source,canonical_rxn,catalyst1,solvent1,solvent2,reagent1,reagent2,dataset
US20070112015A1,CCOC(=O)CN(CC(C)=O)c1c(C)cc(C)cc1C>>Cc1cc(C)c(N2CC(=O)CC(=O)C2)c(C)c1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20130053359A1,COC(=O)c1cc(I)c(N)cc1OC.N#C[Zn]C#N>>COC(=O)c1cc(C#N)c(N)cc1OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOCC,CN(C)C=O,CO,O,val
US20130274269A1,C[C@H](CNCc1ccccc1)NS(=O)(=O)c1ccc2cnccc2c1.Cl.ClCCl>>C[C@H](CNCc1ccccc1)NS(=O)(=O)c1ccc2cnccc2c1.Cl.Cl,,ClCCl,,CCOCC,,val
US04485257,CC(C)=C[C@H]1[C@H](C(=O)Cl)C1(C)C.CC(C)=C[C@H]1[C@H](C(=O)O)C1(C)C>>CC(C)=C[C@H]1[C@H](C(=O)OC(=O)[C@H]2[C@H](C=C(C)C)C2(C)C)C1(C)C,,c1ccncc1,,Cc1ccccc1,,val
US20130338066A1,CC(C)(O)C(F)(c1cccc(Br)c1)S(N)(=O)=O.CCOC(OCC)(OCC)OCC>>CCOC1=NS(=O)(=O)C(F)(c2cccc(Br)c2)C(C)(C)O1,,CC(=O)O,,,,val
US20140163025A1,COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccc(CCC(C)(C)O)cc5C#N)ccc(F)c43)ccc21>>CC(C)(O)CCc1ccc(Oc2ccc(F)c3c2CC[C@H]3Oc2ccc3c(c2)OC[C@H]3CC(=O)O)c(C#N)c1,,CCO,,[K+].[OH-],,val
US04734418,CCOC(=O)c1cnc(N2CCN(Cc3ccccc3)CC2)nc1CCl.NC1CCCCC1>>O=C1c2cnc(N3CCN(Cc4ccccc4)CC3)nc2CN1C1CCCCC1,,CC(C)CCO,,,,val
US20050026975A1,CCOC(=O)c1cc2c([N+](=O)[O-])cccc2[nH]1.ClCc1ccc(Cl)c(Cl)c1>>CCOC(=O)c1cc2c([N+](=O)[O-])cccc2n1Cc1ccc(Cl)c(Cl)c1,,CN(C)C=O,,[I-].[K+],,val
US07049311B1,COc1cc2c(c(OC)c1OCc1ccccc1)N(C(=O)OCC[Si](C)(C)C)[C@@H](O)[C@@H]1CCCN1C2=O>>COc1cc2c(c(OC)c1O)N(C(=O)OCC[Si](C)(C)C)[C@@H](O)[C@@H]1CCCN1C2=O,[Pd],CCO,,,,val
US20070004709A1,NS(=O)(=O)c1c(Cl)sc(Cl)c1[N+](=O)[O-]>>Nc1c(Cl)sc(Cl)c1S(N)(=O)=O,[Fe],CCO,O,[Cl-].[NH4+],,val
US04666907,CI.CO.Oc1ccc2c(c1Cl)Sc1ccccc1N2>>COc1ccc2c(c1Cl)Sc1ccccc1N2C,,CO,,CN(C)C=O,[H-].[Na+],val
US20090111794A1,COCC(=O)Cl.c1ccc2sc(Oc3ccc(CN4C[C@@H]5C[C@H]4CN5)cc3)nc2c1>>COCC(=O)N1C[C@@H]2C[C@H]1CN2Cc1ccc(Oc2nc3ccccc3s2)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20050020660A1,C#C[Si](CC)(CC)CC.CON(C)C(=O)C1CCCCCC1>>C[Si](C)(C)C#CC(=O)C1CCCCCC1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20150266857A1,NC(=O)Cn1c(=O)oc2cc(-c3cn(S(=O)(=O)c4ccccc4)c4ccc(F)cc34)ccc21>>NC(=O)Cn1c(=O)oc2cc(-c3c[nH]c4ccc(F)cc34)ccc21,,CO,O,Cl,[Na+].[OH-],val
US04414390,COc1ccc(-c2nc3ccccn3c2C[N+](C)(C)C)c2ccc(=O)[nH]c12.[C-]#N>>COc1ccc(-c2nc3ccccn3c2CC#N)c2ccc(=O)[nH]c12,,O,,[I-].[Na+],,val
US20090176775A1,CC(C)(C)OC(=O)NN1CCC2(CC2(F)F)c2ccccc21>>FC1(F)CC12CCNc1ccccc12,,C1COCCO1,ClCCl,Cl,,val
US20070287842A1,Nc1ccc2c(c1)Cc1ccccc1-2.O=Cc1cccs1>>Nc1ccc2c(c1)C(=Cc1cccs1)c1ccccc1-2,,CC(C)O,,O=C(O)C(F)(F)F,,val
US20060281710A1,CCOc1cc2c(cc1OCc1ccccc1)CC[C@H]1[C@@H]3[C@@H](CC=CC(=O)OC)CC(=O)[C@@]3(C)CC[C@H]21>>CCOc1cc2c(cc1O)CC[C@H]1[C@@H]3[C@@H](CCCC(=O)OC)CC(=O)[C@@]3(C)CC[C@H]21,[Pd],C1CCOC1,CO,,,val
US20060030610A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCc1cnc2c(Cl)c(Nc3ccc(Br)cc3Cl)c(C(=O)OC)cn12>>COC(=O)c1cn2c(CNCC(=O)OC(C)(C)C)cnc2c(Cl)c1Nc1ccc(Br)cc1Cl,,ClCCl,,CCN(CC)CC,,val
US05840732,CC=C1SC(=O)N(CCCCSc2cccc3nccn23)C1=O.Cl>>CC=C1SC(=O)N(CCCCSc2cccc3nccn23)C1=O.Cl,,CO,,,,val
US04753674,CCC(Oc1ccc([N+](=O)[O-])cc1)C(=O)Cl.COc1ccccc1CN>>CCC(Oc1ccc([N+](=O)[O-])cc1)C(=O)NCc1ccccc1OC,,Cc1ccccc1,,c1ccncc1,,val
US20030162780A1,CCCN(CC1CCN(C(=O)OC(C)(C)C)CC1)C1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1>>CCCN(CC1CCNCC1)C1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080153836A1,CC(=O)Cl.COC(=O)c1ccc(CO)cc1N>>COC(=O)c1ccc(CO)cc1NC(C)=O,,C1COCCO1,,,,val
US05733912,Cc1cncc(C23CCCN2CCC3)c1.Cl>>Cc1cncc(C23CCCN2CCC3)c1.Cl,,CCOCC,,,,val
US04287341,COS(=O)(=O)OC.COc1c(O)ccc(C=O)c1[N+](=O)[O-]>>COc1ccc(C=O)c([N+](=O)[O-])c1OC,,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20110130417A1,O=C(O)CBr.O=C1N(c2ccc(C3CC3)cc2)CCC12CCNCC2>>O=C(O)CN1CCC2(CC1)CCN(c1ccc(C3CC3)cc1)C2=O,,ClCCl,,CCN(CC)CC,,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCc3ccccc3)cc1CC2CC>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2CC,[Pd],C1CCOC1,CO,,,val
US20120058989A1,Cc1ccc(S(=O)(=O)OC[C@@H]2C[C@H](NC(=O)OCc3ccccc3)CN2C(=O)OCc2ccccc2)cc1.[N-]=[N+]=[N-]>>[N-]=[N+]=NC[C@@H]1C[C@H](NC(=O)OCc2ccccc2)CN1C(=O)OCc1ccccc1,,CN(C)C=O,O,CCOC(C)=O,,val
US20100016308A1,CC(C)CCC(=O)c1ccc(C(F)(F)F)cc1>>CC(C)CCC(O)c1ccc(C(F)(F)F)cc1,,CCO,,[BH4-].[Na+],,val
US20050153970A1,CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1N.Cn1nnnc1-c1cccc(NC(=O)Oc2ccccc2)c1>>CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1,,CC#N,,CCN(CC)CC,,val
US20090137804A1,CNc1cc(Nc2ccc(F)cc2)ncn1.O=C=Nc1c(Cl)cccc1Cl>>CN(C(=O)Nc1c(Cl)cccc1Cl)c1cc(Nc2ccc(F)cc2)ncn1,,CN(C)C=O,,CCN(CC)CC,,val
US20100317582A1,CCOC(=O)c1c(C)ncn1C1C=CC(NC(C)c2cccc3ccccc23)C1>>CCOC(=O)c1c(C)ncn1C1CCC(NC(C)c2cccc3ccccc23)C1,[Pd],CC(C)O,,[H][H],,val
US20160185785A1,N#Cc1cccc(-n2ccc3c(=O)[nH]cnc32)c1.O=C(c1ccc(F)cc1)N1CCC2(CC1)CO2>>N#Cc1cccc(-n2ccc3c(=O)n(CC4(O)CCN(C(=O)c5ccc(F)cc5)CC4)cnc32)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120077828A1,CC(C)n1cc(Br)c2c(N)ncnc21.CC1(C)OB(c2ccc3c(c2)CCN3C(=O)Cc2cc(F)ccc2F)OC1(C)C>>CC(C)n1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cc(F)ccc2F)c2c(N)ncnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])O.[Na+],,val
US20070208063A1,CC(=O)c1nc([C@@H](O)[C@H](O)[C@H](O)CO)c[nH]1.CCOC(=O)NN>>CCOC(=O)N/N=C(\C)c1nc([C@@H](O)[C@H](O)[C@H](O)CO)c[nH]1,Cl,CO,O,,,val
US05140011,CC(C)[C@@H](CCNC(=N)NC(=O)OCc1ccccc1)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C.Cl>>CC(C)[C@@H](CCNC(=N)N)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C.Cl,[Pd],CO,,c1ccncc1,,val
US20150203511A1,COc1ccc(B(O)O)cc1C.Cn1cc(Br)cn1>>COc1ccc(-c2cnn(C)c2)cc1C,,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US06350749B1,Cc1ccc(Cl)c(C2CC(=O)c3c(C)cnnc3C2)c1.Cl.N=C(N)NN>>Cc1ccc(Cl)c(C2CC(=NNC(=N)N)c3c(C)cnnc3C2)c1.Cl,,CCO,,Cl,,val
US05494928,O=C(O)c1cc2cc(Cl)c(F)cc2[nH]1.O=C(O)c1cc2ccc(F)c(Cl)c2[nH]1>>Fc1cc2[nH]ccc2cc1Cl.Fc1ccc2cc[nH]c2c1Cl,,c1ccc(Oc2ccccc2)cc1,,,,val
US20150119405A1,CC1(C)C[C@@H](N=[N+]=[N-])[C@@H](NC(=O)OCC[Si](C)(C)C)CO1>>CC1(C)C[C@@H](N)[C@@H](NC(=O)OCC[Si](C)(C)C)CO1,[Pd],CO,,[H][H],,val
US20100204226A1,CCOC(=O)N=C(Nc1ccc(Oc2c(C)cccc2C)c(C)c1)n1cc(C(=O)OCC)cn1>>CCOC(=O)c1cnn(-c2nc3cc(C)c(Oc4c(C)cccc4C)cc3c(=O)[nH]2)c1,Cl[Ti](Cl)(Cl)Cl,CCO,,ClCCCl,,val
US20150158879A1,CCOC(=O)[C@@H]1C[C@@H](n2c(Cn3nc(S(C)(=O)=O)c4ccncc43)nc3cc(Cl)ccc32)C1>>CS(=O)(=O)c1nn(Cc2nc3cc(Cl)ccc3n2[C@@H]2C[C@@H](CO)C2)c2cnccc12,,CCO,,[BH4-].[Na+],,val
US20090264445A1,CCOC(=O)/C=C(\C)Oc1ccc(C)nc1.O=C1CCC(=O)N1Br>>CCOC(=O)/C=C(\CBr)Oc1ccc(C)nc1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20120010414A1,COC(=O)c1cccc(-c2cc(CN(C(=O)c3ncn(C)n3)C3CCOCC3)ccc2F)c1>>Cn1cnc(C(=O)N(Cc2ccc(F)c(-c3cccc(CO)c3)c2)C2CCOCC2)n1,,CC(C)=O,O,CCO,[BH4-].[Na+],val
US20120142671A1,Cc1cc(Nc2cc(N[C@H](Cc3ccc(-c4ccncc4)cc3)C(N)=O)c(F)cc2C#N)sn1.OO>>Cc1cc(Nc2cc(N[C@H](Cc3ccc(-c4ccncc4)cc3)C(N)=O)c(F)cc2C(N)=O)sn1,,CCO,CS(C)=O,CC(=O)O,[Na+].[OH-],val
US20030176430A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@H](N)CN2[C@H](C(c2ccccc2)c2ccccc2)C1.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)N1C[C@@H]2C[C@H](NC(=O)OCc3ccccc3)CN2[C@H](C(c2ccccc2)c2ccccc2)C1,,ClCCl,,CCN(CC)CC,O,val
US05962682,COC(=O)c1cc(N)c(Oc2ccccc2OC)c(OCCOC2CCCCO2)c1.COc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)c1cc(NS(=O)(=O)c2ccc(OC)cc2)c(Oc2ccccc2OC)c(OCCOC2CCCCO2)c1,,Cc1ccccc1,c1ccncc1,,,val
US20130102776A1,CC(C)(C)OC(=O)N1CCC(CCC=O)CC1.COP(=O)(OC)C(=[N+]=[N-])C(C)=O>>C#CCCC1CCN(C(=O)OC(C)(C)C)CC1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20110201599A1,Nc1nccc(-c2c[nH]c3ncc([N+](=O)[O-])cc23)n1>>Nc1cnc2[nH]cc(-c3ccnc(N)n3)c2c1,[Pd],CCO,,CO,,val
US20050038035A1,CC(C)(C)OC(=O)Nc1nc(CCN)cs1.O=[N+]([O-])c1ccc(Cl)nc1>>CC(C)(C)OC(=O)Nc1nc(CCNc2ccc([N+](=O)[O-])cn2)cs1,,CN(C)C=O,,CCN(CC)CC,,val
US20100130738A1,COCn1c(C(F)(F)F)nc2c(C3=NNC(=O)C3(C)C)ccc(OC)c21>>COc1ccc(C2=NNC(=O)C2(C)C)c2[nH]c(C(F)(F)F)nc12,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20150291596A1,CC(C)[Si](Cl)(O[Si](Cl)(C(C)C)C(C)C)C(C)C.COc1ncnc2c([C@H]3[C@H](O)[C@H](O)[C@@H](CO)N3C(=O)OC(C)(C)C)cn(COCc3ccccc3)c12>>COc1ncnc2c([C@H]3[C@H](O)[C@@H]4O[Si](C(C)C)(C(C)C)O[Si](C(C)C)(C(C)C)OC[C@H]4N3C(=O)OC(C)(C)C)cn(COCc3ccccc3)c12,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20070287842A1,CCN(CC)c1ccc(C=O)s1.N#Cc1ccsc1N>>CCN(CC)c1ccc(C=Nc2sccc2C#N)s1,,CC(C)O,,O=C(O)C(F)(F)F,,val
US20080249090A1,Cc1cc[nH]c(=O)c1-c1ccc2nc(N)ncc2c1.Clc1cccc(I)c1>>Cc1ccn(-c2cccc(Cl)c2)c(=O)c1-c1ccc2nc(N)ncc2c1,[Cu]I,C1COCCO1,,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20030207888A1,C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(OCc4ccccc4)nc3N21>>C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(O)nc3N21,[Pd],CCOC(C)=O,CO,,,val
US05688810,C1CCOC1.CC(C)(C)OC(=O)N1CCC(=O)c2ccccc21>>CC1CN(C(=O)OC(C)(C)C)c2ccccc2C1=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20050059677A1,CCSSCC.Fc1ccc(-c2nn3ccc(Cl)cc3c2-c2ccnc(NC3CCCC3)n2)cc1>>CCSc1cc(Cl)cc2c(-c3ccnc(NC4CCCC4)n3)c(-c3ccc(F)cc3)nn12,,C1CCOC1,CCOC(C)=O,O,[Li]CCCC,val
US20130210795A1,ClCCl.Nc1cccc(CO)c1.O=S(Cl)Cl>>Cl.Nc1cccc(CCl)c1,,ClCCl,,,,val
US20140357858A1,COc1cccc(S(=O)(=O)Cl)c1.Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1>>COc1cccc(S(=O)(=O)Nc2ccc(N3C(=O)CC(=O)Nc4c3ccc3ccccc43)cc2)c1,,c1ccncc1,,,,val
US20140275118A1,CC1(C)OB(c2ccn[nH]2)OC1(C)C.CCOC(=O)c1c(Br)cccc1OC>>CCOC(=O)c1c(OC)cccc1-c1ccn[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US04576949,CCOC(=O)c1cc2c(nc1C)CCCC2>>Cc1nc2c(cc1C(=O)O)CCCC2,,CO,,[Na+].[OH-],,val
US20070225267A1,CCO[C@H]1CN(C(=O)OC(C)(C)C)C([C@@H](O)[C@H](Cc2cc(F)cc(F)c2)[N+](=O)[O-])CO1>>CCO[C@H]1CN(C(=O)OC(C)(C)C)C([C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)CO1,Cl[Ni]Cl,CO,,O,[BH4-].[Na+],val
US20050059650A1,CC(C)OC(=O)N1CCC(Oc2ccnc3c(Cl)cccc23)CC1.CSc1ccc(B(O)O)cc1>>CSc1ccc(-c2cccc3c(OC4CCN(C(=O)OC(C)C)CC4)ccnc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US06432993B1,CC(C)(C)C(=O)Cl.Cc1cc(O)c(Cl)c(C)c1O>>Cc1cc(OC(=O)C(C)(C)C)c(Cl)c(C)c1O,,ClCCl,,c1ccncc1,,val
US20080009530A1,CC(C)(C)COC(=O)Cl.CCCCOc1cc(CCS(N)(=O)=O)n(Cc2ccc(Cl)cc2Cl)n1>>CCCCOc1cc(CCS(=O)(=O)NC(=O)OCC(C)(C)C)n(Cc2ccc(Cl)cc2Cl)n1,CN(C)c1ccncc1,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20070249670A1,CC(C)(C)OC(=O)c1cc(Br)sc1NC(=O)Nc1c(Cl)cccc1Cl.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>Cn1cc(-c2cc(C(=O)OC(C)(C)C)c(NC(=O)Nc3c(Cl)cccc3Cl)s2)cn1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US05028606,BrCc1cccc2nccnc12.c1c[nH]cn1>>c1cc(Cn2ccnc2)c2nccnc2c1,,CC#N,,,,val
US20160002215A1,CO.O=C(O)Cc1ccc(Br)c(F)c1>>COC(=O)Cc1ccc(Br)c(F)c1,,CO,,CN(C)C=O,O=S(Cl)Cl,val
US20060252812A1,NCCN1C(=O)C2(COc3cc4c(cc32)OCO4)c2ccccc21.O=C=Nc1ccc(F)cc1>>O=C(NCCN1C(=O)C2(COc3cc4c(cc32)OCO4)c2ccccc21)Nc1ccc(F)cc1,CCN(CC)CC,ClCCl,,,,val
US20140296230A1,CC1(c2ccccc2)NC(=O)N(Cc2ccccc2)c2ccccc21.CI>>CN1C(=O)N(Cc2ccccc2)c2ccccc2C1(C)c1ccccc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20060194768A1,Brc1cccc(C2OCCO2)c1.O=Cc1cccc(C(F)(F)F)c1>>OC(c1cccc(C2OCCO2)c1)c1cccc(C(F)(F)F)c1,,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US20030195193A1,COc1ccc(C(=O)Cl)cc1.Nc1c(O)cccc1[N+](=O)[O-]>>COc1ccc(C(=O)Nc2c(O)cccc2[N+](=O)[O-])cc1,,c1ccncc1,,,,val
US20120015940A1,C[C@H](OC(=O)Oc1ccc([N+](=O)[O-])cc1)C(F)(F)F.Cc1cc(Nc2cc[nH]n2)nc(N2C[C@H]3OCCN[C@@H]3C2)n1>>Cc1cc(Nc2cc[nH]n2)nc(N2C[C@@H]3[C@@H](C2)OCCN3C(=O)O[C@@H](C)C(F)(F)F)n1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US04599344,CC(=O)C(CC1C(=O)C2CCN1CC2)C(=O)c1ccc(Cl)cc1.Cl>>Cl.O=C(CCC1C(=O)C2CCN1CC2)c1ccc(Cl)cc1,,Cl,,,,val
US20070167406A1,Nc1cccc(C(F)(F)F)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1cccc(C(F)(F)F)c1)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US04871737,CCCCN(CCCC)C(=S)NN.CCOC(=O)C(Cl)C(C)=O>>CCCCN(CCCC)c1n[nH]c(C)c1C(=O)OCC.Cl,,CCO,,,,val
US20140179695A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1(C)Oc2ccc(Br)cc2[C@@]2(COC(N)=N2)C12CC2>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)C1=N[C@@]2(CO1)c1cc(Br)ccc1OC(C)(C)C21CC1,CN(C)c1ccncc1,C1CCOC1,,,,val
US05310920,ClCc1ccc(Cl)nc1.O=CC=CN1CCNC1=N[N+](=O)[O-]>>O=CC=CN1CCN(Cc2ccc(Cl)nc2)C1=N[N+](=O)[O-],,O,,CN(C)C=O,[H-].[Na+],val
US20030078277A1,CC(=O)C1CCOC1=O.Cc1cc(N)n[nH]1>>Cc1cc2nc(C)c(CCO)c(O)n2n1,,Cc1ccccc1,,CC(=O)O,,val
US20080311164A1,CC(C)OC(=O)C1CCC(=O)N1.CCCCCCCCCCCC(=O)Cl>>CCCCCCCCCCCC(=O)N1C(=O)CCC1C(=O)OC(C)C,,Cc1ccccc1,,CCN(CC)CC,,val
US06787651B2,CCOC(=O)c1c(-c2ccc(OC)cc2)c2ccccc2n1Cc1cccc(OCc2ccccc2)c1>>CCOC(=O)c1c(-c2ccc(OC)cc2)c2ccccc2n1Cc1cccc(O)c1,[Pd],CCOC(C)=O,,,,val
US20140243349A1,O=C(O)c1ccc2sccc2c1>>OCc1ccc2sccc2c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090264650A1,CC(=O)OCC(=O)Nc1ccc(CC2CCN(C3CCCCC3)C2=O)c(Cl)c1>>O=C(CO)Nc1ccc(CC2CCN(C3CCCCC3)C2=O)c(Cl)c1,,C1CCOC1,,Cl,[K+].[OH-],val
US20040038963A1,CCO.CCOC(=O)C(CCCCCCCc1nc2c(cc1Br)CCCN2)c1cnc(C)nc1>>CCOC(=O)C(CCCCCCCc1ccc2c(n1)NCCC2)c1cnc(OC)nc1,[Ni],,,,,val
US20120171245A1,CCOC(=O)C1(C)CCCCC1=O.NO>>CC12CCCCC1=NOC2=O,,CCO,,Cl,c1ccncc1,val
US20050250798A1,Cc1ccc(S(=O)(=O)OC[C@@H]2CCCN2S(=O)(=O)c2ccc3c(c2)C2(OCCCO2)C2=NCC(C)(C)CN23)cc1.NC1CCCCC1>>CC1(C)CN=C2C(=O)c3cc(S(=O)(=O)N4CCC[C@H]4CNC4CCCCC4)ccc3N2C1,,C1CCOC1,,,,val
US20020042421A1,CC(C)(C)OC(=O)N1CCNCC1.O=C1CC2CCC(C1)N2Cc1ccccc1>>CC(C)(C)OC(=O)N1CCN(C2CC3CCC(C2)N3Cc2ccccc2)CC1,CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C,CO,,[BH4-].[Na+],,val
US04866086,CC(Br)C(=O)c1ccc(C(F)(F)F)cn1.c1nc[nH]n1>>CC(C(=O)c1ccc(C(F)(F)F)cn1)n1cncn1,,CC#N,CCOC(C)=O,[Na],,val
US20050080111A1,CC(=O)c1cc(Br)co1.CCC(F)(F)C(=O)OCc1ccccc1>>CCC(F)(F)C(=O)CC(=O)c1cc(Br)co1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20050059713A1,COC(=O)c1cc(Br)cc(Cl)c1OC.OB(O)c1ccc(C(F)(F)F)cc1>>COC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)cc(Cl)c1OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,[Cs+].[F-],,val
US04831026,CCOC(=O)CN1C(=O)O[C@H](c2ccccc2)[C@@H]1c1ccccc1>>O=C(O)CN1C(=O)O[C@H](c2ccccc2)[C@@H]1c1ccccc1,,C1CCOC1,O,[Na+].[OH-],,val
US20140323501A1,CC(C)C(=O)O.CCOC(=O)C(CC(=O)c1ccc(Sc2ccc(C(=O)CCl)cc2)cc1)(NC(C)=O)C(=O)OCC>>CCOC(=O)C(CC(=O)c1ccc(Sc2ccc(C(=O)COC(=O)C(C)C)cc2)cc1)(NC(C)=O)C(=O)OCC,,CC#N,,CCN(CC)CC,,val
US05563141,C=CC(CO)CC(=O)OC.CCOC(=O)N=NC(=O)OCC.Oc1ccc(N2CCN(c3ccncc3)CC2)cc1>>C=CC(COc1ccc(N2CCN(c3ccncc3)CC2)cc1)CC(=O)OC.[NH4+].[OH-],,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060148858A1,CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.COC(=O)Cc1cccc(F)c1O>>CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1c(F)cccc1CC(=O)O,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20120252758A1,COc1ccc(F)cc1C(C)C(F)(F)F>>CC(c1cc(F)ccc1O)C(F)(F)F,,ClCCl,,BrB(Br)Br,O,val
US04287300,CO.O=C(O)c1ccc([N+](=O)[O-])c(O)c1>>COC(=O)c1ccc([N+](=O)[O-])c(O)c1,,CO,,CC(=O)Cl,,val
US20050038031A1,CNC(=O)c1cc(Cl)ccn1.NC(=O)c1cc(Oc2ccc(N)cc2)ccn1>>CNC(=O)CNC(=O)c1cc(Oc2ccc(N)cc2)ccn1,,CCOC(C)=O,,,,val
US20120232056A1,CC[C@@H](C)Nc1nc2cc(C(=O)OC)ccc2nc1OS(=O)(=O)C(F)(F)F.OB(O)c1cc2cc(F)ccc2o1>>CC[C@@H](C)Nc1nc2cc(C(=O)OC)ccc2nc1-c1cc2cc(F)ccc2o1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20100190747A1,CC(C)(C)CCO.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)CCOc1ccc([N+](=O)[O-])cc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20010021714A1,O=C(O)Cc1ccc2c(c1)OCO2>>CC(O)c1ccc2c(c1)OCO2,,C1CCOC1,,B,,val
US20040209892A1,CC(=O)Nc1cccc(Oc2ccc([N+](=O)[O-])c([N+](=O)[O-])c2)c1>>CC(=O)Nc1cccc(Oc2ccc(N)c(N)c2)c1,[Pd],CO,,,,val
US20070244159A1,CC(C)(C)C1Cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)ccc2N1CCCl.[C-]#N>>CC(C)(C)C1Cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)ccc2N1CCC#N,,CCO,,O,,val
US20090186879A1,CCC(CC)c1ccc(Cl)c2nc3n(c12)CCN3c1ccc(Br)cc1Cl.CN(C)C=O>>CCC(CC)c1ccc(Cl)c2nc3n(c12)CCN3c1ccc(C=O)cc1Cl,,C1CCOC1,,[Li]CCCC,,val
US20130172330A1,C#CCN(C)C1CCCc2cccnc21.O=Cc1cn(CCCN2C(=O)c3ccccc3C2=O)nn1>>CN(Cc1cn(CCCN2C(=O)c3ccccc3C2=O)nn1)C1CCCc2cccnc21,CC(=O)O,ClCCCl,,O=C([O-])O.[Na+],,val
US06723722B1,CC(C)(C)OC(=O)N1CCC(NN2CCNCC2=O)CC1.O=S(=O)(Cl)c1ccc2cc(Cl)ccc2c1>>CC(C)(C)OC(=O)N1CCC(NN2CCN(S(=O)(=O)c3ccc4cc(Cl)ccc4c3)CC2=O)CC1,,CCOC(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20100331338A1,CCCOc1sc(C(=O)O)cc1S(C)(=O)=O.Nc1nccs1>>CCCOc1sc(C(=O)Nc2nccs2)cc1S(C)(=O)=O,,O=S(Cl)Cl,,C1CCOC1,CCN(CC)CC,val
US20110065681A1,COC(=O)c1cc(Br)cc(S(=O)(=O)C2CCCC2)c1.Cc1ccc(B(O)O)cc1>>COC(=O)c1cc(-c2ccc(C)cc2)cc(S(=O)(=O)C2CCCC2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,Cc1ccccc1,O=C([O-])[O-].[Cs+].[Cs+],val
US20110033539A1,C=CCC1(S(=O)(=O)Nc2c(F)cc(F)c(F)c2Nc2ccc(I)cc2F)CC1.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>O=S(=O)(Nc1c(F)cc(F)c(F)c1Nc1ccc(I)cc1F)C1(CC(O)CO)CC1,O=[Os](=O)(=O)=O,C1CCOC1,O,CCOC(C)=O,,val
US20100160255A1,CCN1C(=O)OC2(CCCN(C3CCN(C(=O)c4cc(-c5cccnc5)sc4NC(=O)OC(C)(C)C)CC3)C2)C1=O>>CCN1C(=O)OC2(CCCN(C3CCN(C(=O)c4cc(-c5cccnc5)sc4N)CC3)C2)C1=O,,O=C(O)C(F)(F)F,,O=C([O-])O.[Na+],,val
US20140323519A1,C[Si](C)(C)CCOCCl.Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Br>>Cc1ccc(N(COCC[Si](C)(C)C)C(=O)c2cccc(C(C)(C)C#N)c2)cc1Br,,CN(C)C=O,,[H-].[Na+],,val
US05081145,COC(=O)c1c(C)c2cc(OC)ccc2n1Cc1ccc(Cl)cc1>>COc1ccc2c(c1)c(C)c(CO)n2Cc1ccc(Cl)cc1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20040053973A1,CCc1nc(-c2cccc(Br)c2)c(-c2ccnc(NC(=O)OC(C)(C)C)c2)s1.N#C[Cu]C#N>>CCc1nc(-c2cccc(C#N)c2)c(-c2ccnc(N)c2)s1,,CN(C)C=O,,N,O,val
US20090221596A1,COc1c(Cl)cc(OC=CC(Cl)Cl)cc1CCC(C)=O.NO>>COc1c(Cl)cc(OCC=C(Cl)Cl)cc1C(C)=NO,,CCO,,,,val
US20120264749A1,CC(C)(C)OC(=O)N1CCC2(CC1)CN(CC(F)F)CC(c1ncco1)O2.Cl>>Cl.FC(F)CN1CC(c2ncco2)OC2(CCNCC2)C1,,ClCCl,,,,val
US20120196884A1,Nc1ccc(NC(=O)Nc2ccccc2)nc1.O=S(=O)(Cl)c1cccc(-c2ccc(F)cc2)c1>>O=C(Nc1ccccc1)Nc1ccc(NS(=O)(=O)c2cccc(-c3ccc(F)cc3)c2)cn1,,ClCCl,,c1ccncc1,,val
US20150031685A1,CC(C)(C)[Si](C)(C)O[C@H]1CCN(C[C@@H](O)c2cc(F)cc(C#N)c2)C1.CN>>CN[C@H](CN1CC[C@H](O[Si](C)(C)C(C)(C)C)C1)c1cc(F)cc(C#N)c1,,ClCCl,,CS(=O)(=O)Cl,,val
US05654297,Cc1ccoc1CC(=O)Nc1ccc(C(=O)Cl)cn1.c1cc2c(s1)CCCCN2>>Cc1occc1C(=O)Nc1ccc(C(=O)N2CCCCc3sccc32)cn1,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US03994941,C=O.Cc1nnc2n1-c1ccc(Br)cc1C(c1ccccn1)=NC2>>OCCc1nnc2n1-c1ccc(Br)cc1C(c1ccccn1)=NC2,,Cc1ccccc1C,,,,val
US20050215574A1,CC(=O)OC(C)=O.COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1O[C@H]1CCCNC1>>COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1O[C@H]1CCCN(C(C)=O)C1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20040110767A1,Cc1ccc(S(=O)(=O)Oc2ccc(CNc3ccc(OCCN4CCCC4)cc3)cc2)cc1.O=C(Cl)C1CCCCC1>>Cc1ccc(S(=O)(=O)Oc2ccc(CN(C(=O)C3CCCCC3)c3ccc(OCCN4CCCC4)cc3)cc2)cc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20090286837A1,C[C@@H](C(=O)O)N(C)C(=O)OC(C)(C)C.Cl.[NH-]Cc1ccc([N+](=O)[O-])cc1>>CN[C@@H](C)C(=O)O.Cl.[NH-]Cc1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,,CO,ClC(Cl)Cl,val
US05631208,CC(=O)C=Cc1c(C)c(C)c2c(c1Cl)OC(C)(C)C2.CCOC(=O)CC(=O)OCC>>Cc1c(C)c(C2CC(=O)C=C(O)C2)c(Cl)c2c1CC(C)(C)O2,,CO,,O,[Na],val
US20120108589A1,CCc1n[nH]c2c1ccc[n+]2[O-].O=P(Cl)(Cl)Cl>>CCc1n[nH]c2nccc(Cl)c12,,CC(Cl)Cl,,,,val
US20140121200A1,CC(C)(C)OC(=O)N1CC(CN)CC(O[Si](C)(C)C(C)(C)C)C1.Clc1cc2nccnc2c(Cl)n1>>CC(C)(C)OC(=O)N1CC(CNc2nc(Cl)cc3nccnc23)CC(O[Si](C)(C)C(C)(C)C)C1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US05441964,C1CCNC1.COc1ccc2c(C(=O)c3ccc(OCCCl)cc3)c(C3CCCCC3)sc2c1>>COc1ccc2c(C(=O)c3ccc(OCCN4CCCC4)cc3)c(C3CCCCC3)sc2c1,,O,,C1CCOC1,[H-].[Na+],val
US20100317647A1,CCOC(=O)[C@@H]1CC(O[Si](C)(C)C(C)(C)C)C[C@H]1CO.Oc1ccc(Cl)cc1>>CCOC(=O)[C@@H]1CC(O[Si](C)(C)C(C)(C)C)C[C@H]1COc1ccc(Cl)cc1,,C1CCOC1,ClCCl,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130317026A1,Cc1cc(C)c(CNC(=O)c2cc(Br)nc3c2cnn3C(C)C)c(=O)[nH]1.Nc1ncc(B(O)O)cn1>>Cc1cc(C)c(CNC(=O)c2cc(-c3cnc(N)nc3)nc3c2cnn3C(C)C)c(=O)[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20110003820A1,CC1c2ccc(C(=O)C(Cl)(Cl)Cl)n2CCN1C(=O)OC(C)(C)C.CN>>CNC(=O)c1ccc2n1CCN(C(=O)OC(C)(C)C)C2C,,CO,,,,val
US20070232632A1,BrCc1ccccc1.CCOC(=O)N=S(C)(=O)c1ccc(Nc2ncc(-c3nn[nH]n3)c(NC3CCCCC3)n2)cc1>>CCOC(=O)N=S(C)(=O)c1ccc(Nc2ncc(-c3nnn(Cc4ccccc4)n3)c(NC3CCCCC3)n2)cc1,,CCC(C)=O,,[I-].[K+],,val
US04581369,Cc1cc(C)c(C(=O)c2cccc(F)c2)c(C)c1.c1c[nH]cn1>>Cc1cc(C)c(C(=O)c2cccc(-n3ccnc3)c2)c(C)c1,,CN(C)P(=O)(N(C)C)N(C)C,,[H-].[Na+],,val
US05780498,COC(=O)C1Cc2ccccc2CN1.Cc1cc(C)cc(C(=O)O)c1>>COC(=O)C1Cc2ccccc2CN1C(=O)c1cc(C)cc(C)c1,,CCOC(C)=O,CN(C)C=O,CCN=C=NCCCN(C)C,Cl,val
US05521192,Cc1cc(Cl)nc(N)n1.N>>Cc1cc(N)nc(N)n1,,CO,,,,val
US05559230,CC(C)(C)OC(=O)NCC(=O)O.Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N)c3ccccc32)cc1>>Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(NC(=O)CN)c3ccccc32)cc1,,CN(C)C=O,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20130274229A1,CCC(CC)[C@H](NC(C)=O)[C@H]1[C@H](NC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)C[C@H](C(=O)OC)[C@H]1O.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CCC(CC)[C@H](NC(C)=O)[C@H]1[C@H](NC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)C[C@H](C(=O)OC)[C@H]1OC(=O)Oc1ccc([N+](=O)[O-])cc1,CN(C)c1ccncc1,,,c1ccncc1,,val
US04143154,CCOC(=O)Cc1ccc2occ(-c3ccc(Br)cc3)c2c1.c1ccncc1>>CCOC(=O)Cc1ccc2occ(-c3ccc(C#N)cc3)c2c1,,ClC(Cl)Cl,,Cl,,val
US20040157881A1,CCOC(=O)c1ccc(-c2nnc(-c3ccccc3[N+](=O)[O-])o2)cc1>>CCOC(=O)c1ccc(-c2nnc(-c3ccccc3N)o2)cc1,[Pd],C1CCOC1,,,,val
US20090149466A1,Fc1cccc(CN2CCNCC2)c1.O=c1cc(N2CCNCC2)nc[nH]1>>O=c1cc(N2CCN(Cc3cccc(F)c3)CC2)nc[nH]1,,CCC(C)O,,CCN(C(C)C)C(C)C,,val
US20080318935A1,CC(C)N.CN1CCCn2c(-c3ccccc3)nc(C(=O)N[C@H](C(=O)O)C(C)(C)C)c2C1>>CC(C)NC(=O)[C@@H](NC(=O)c1nc(-c2ccccc2)n2c1CN(C)CCC2)C(C)(C)C,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20050192347A1,CC(CO)(CCCN1C(=O)c2ccccc2C1=O)c1ccccc1>>CC(CO)(CCCN)c1ccccc1,,CCO,ClCCl,NN,O,val
US20080064876A1,CN(C)N=Cc1ccco1.O=C1C=CC(=O)O1>>CN(C)N=Cc1cccc2c1C(=O)OC2=O,,CCOC(C)=O,,O=C(O)C(F)(F)F,,val
US20160221945A1,COc1cc(Br)cc(CN2C(=O)c3ccccc3C2=O)c1>>COc1cc(Br)cc(CN)c1,,CO,,NN,O,val
US20070208007A1,CCCI.N#Cc1ccc(N)c(NC(=O)CCCCN2CCCCC2)c1>>CCCn1c(CCCCN2CCCCC2)nc2ccc(C#N)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20090099187A1,CCc1cccc2c1C[C@@H](NC(=O)C(F)(F)F)CO2.O=S(=O)(O)Cl>>CCc1ccc(S(=O)(=O)Cl)c2c1C[C@@H](NC(=O)C(F)(F)F)CO2,CN(C)C=O,ClC(Cl)Cl,,O=S(Cl)Cl,,val
US20140343053A1,Fc1cccc(Br)n1.NN>>NNc1cccc(Br)n1,,C1CCOC1,CCOC(C)=O,,,val
US06072067,CCCC(C)C1(C(C)CCC)C=CC=C1.Cc1ccc(S(=O)(=O)OCCN(C)C)cc1>>CCCC(C)C1(C(C)CCC)C=CC=C1CCN(C)C,,C1CCOC1,O,CCCCCC,[Li]CCCC,val
US20080045526A1,CCC1OC(=O)c2ccsc21.O=C1Cc2cc(F)ccc2N1>>CCC1OC(=C2C(=O)Nc3ccc(F)cc32)c2ccsc21,,C1CCOC1,,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20050159423A1,CCOC=C(C(=O)OCC)C(=O)OCC.CCSc1nc(N)cc(N)n1>>CCOC(=O)C(=CNc1cc(N)nc(SC)n1)C(=O)OCC,,CCO,,,,val
US20040133011A1,CCCCCC12CCC(c3nnc(-c4ccc(OC)cc4Cl)n3C)(CC1)CC2>>CCCCCC12CCC(c3nnc(-c4ccc(O)cc4Cl)n3C)(CC1)CC2,,ClCCl,,BrB(Br)Br,,val
US05506239,COCOC1C[C@@H](C(=O)NCC2CCCCC2)N(C(=O)OCc2ccccc2)C1>>COCOC1CN[C@H](C(=O)NCC2CCCCC2)C1,[Pd],CCO,,,,val
US20100120751A1,O=S(Cl)Cl.O=[N+]([O-])c1ccc(Cl)cc1CO>>O=[N+]([O-])c1ccc(Cl)cc1CCl,,ClCCl,,CCN(CC)CC,,val
US20120264734A1,Cc1[nH]c(=O)c(C#N)c(C)c1F>>Cc1[nH]c(=O)c(CN)c(C)c1F,,CO,N,,,val
US20090137580A1,Cn1ccc2ncnc(Oc3ccc(N)c(Cl)c3)c21.Nc1ccccn1.O=C(Cl)Oc1ccccc1>>Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4ccccn4)c(Cl)c3)c21,,CN1CCCC1=O,,c1ccncc1,,val
US04948810,COC(=O)CNC(=O)C(F)Oc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1>>O=C(O)CNC(=O)C(F)Oc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1,,CO,,Cl,[Na+].[OH-],val
US20030055265A1,C=CCCOC(C(=O)OCC)C(O)c1cc(C)c(OCCc2nc(-c3ccccc3)oc2C)c(C)c1.CS(=O)(=O)Cl>>C=CCCOC(C(=O)OCC)C(OS(C)(=O)=O)c1cc(C)c(OCCc2nc(-c3ccccc3)oc2C)c(C)c1,,ClCCl,,CCN(CC)CC,,val
US20150353553A1,C[C@@H](N)C1CCC1.C[C@@H]1CC[C@@H](Cn2c(C3(c4ccccc4)CCC3)nc3nc(Cl)nc(Cl)c32)CC1>>C[C@H]1CC[C@H](Cn2c(C3(c4ccccc4)CCC3)nc3nc(Cl)nc(N[C@H](C)C4CCC4)c32)CC1,,CCO,,,,val
US05741785,CCOC(=O)c1nc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n2c1CBr.Nc1ccc2c(c1)OCO2>>CCOC(=O)c1nc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n2c1CNc1ccc2c(c1)OCO2,,CC#N,,,,val
US20140336377A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(N)c1ccc(OCC(F)(F)F)nc1>>CC(NC(=O)OC(C)(C)C)c1ccc(OCC(F)(F)F)nc1,,ClCCl,,CCN(CC)CC,Cl,val
US20160145246A1,CC1(C)COCCN1CC(=O)NN.O=C(O)/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1>>CC1(C)COCCN1CC(=O)N(N)C(=O)/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1,,O,,C1CCOC1,CCN(C(C)C)C(C)C,val
US20150218133A1,CC(C)(C)OC(=O)Nc1ccc(C[Si](C)(C)C)c([N+](=O)[O-])c1.COc1nccc(I)c1C=O>>COc1nccc(I)c1C(O)Cc1ccc(NC(=O)OC(C)(C)C)cc1[N+](=O)[O-],,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US07018752B2,C=C(C)C(=O)[O-].C=CC(=O)OC(F)(C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.Cc1ccccc1>>C.C=C(C)C(=O)[O-].C=CC(=O)OC(F)(C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,,Cc1ccccc1,,,,val
US20120289504A1,CNC(=O)c1cc(F)c(-c2nc3cc(C)ccc3n2C[C@@H]2CN(C(=O)OC(C)(C)C)CCO2)c(F)c1.O=C(O)C(F)(F)F>>CNC(=O)c1cc(F)c(-c2nc3cc(C)ccc3n2C[C@@H]2CNCCO2)c(F)c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20140121197A1,Clc1cc(Cl)c(-c2ccccc2)nn1.O=Cc1cccnc1>>OC(c1cccnc1)c1c(Cl)nnc(-c2ccccc2)c1Cl,,C1CCOC1,CCOC(C)=O,O,CC(C)[N-]C(C)C.[Li+],val
US04661505,CCCc1c(OCCCCCc2nnn[nH]2)ccc(C(C)=O)c1O.CI>>CCCc1c(OCCCCCc2nnnn2C)ccc(C(C)=O)c1O,,CCC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100227859A1,COC(=O)CNS(=O)(=O)c1ccc2oc3cc(-c4noc(C(C)(C)C)n4)ccc3c2c1>>CC(C)(C)c1nc(-c2ccc3c(c2)oc2ccc(S(=O)(=O)NCC(=O)O)cc23)no1,,C1CCOC1,O,[Li+].[OH-],,val
US04767882,Cc1ccc2c(c1)C(C)(C)[C@H](CC(=O)O)CC2(C)C>>Cc1ccc2c(c1)C(C)(C)[C@H](CCO)CC2(C)C,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US06740662B1,CCO.CCn1c(=O)c(C(=O)O)c(-c2cccc(Cl)c2)c2ccc(C)nc21.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCOC(=O)Nc1c(-c2cccc(Cl)c2)c2ccc(C)nc2n(CC)c1=O,,O,,CCN(CC)CC,Cc1ccccc1,val
US20070099986A1,O=C(CCCCCl)c1cc2c(c([N+](=O)[O-])c1)OCC2>>Nc1cc(C(=O)CCCCCl)cc2c1OCC2,[Fe],Cl,,CC(=O)O,,val
US20090099173A1,C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(Cl)c2cccnc12.OB(O)c1ccc(Cl)cc1F>>C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(Cl)cc2F)c2cccnc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US06469021B1,COC(=O)c1cc2c(cn1)[nH]c1ccccc12.OCCN1CCOCC1>>O=C(OCCN1CCOCC1)c1cc2c(cn1)[nH]c1ccccc12,CN(C)c1ccncc1,Cc1ccccc1C,,,,val
US20090203737A1,CC(C)(C)OC(=O)N1CCCC(C#N)C1.NO>>CC(C)(C)OC(=O)N1CCCC(C(=N)NO)C1,,CCO,,,,val
US20040229949A1,CCOC(=O)C(Cc1ccc(O)cc1)OCC.N#Cc1ccc(CCO)cc1>>CCOC(=O)C(Cc1ccc(OCCc2ccc(C#N)cc2)cc1)OCC,,CCOC(C)=O,,,,val
US04680391,C=O.CC(=O)OC(C)=O.CCCC1C(=O)NC1Sc1ccc([N+](=O)[O-])cc1>>CCCC1C(=O)N(COC(C)=O)C1Sc1ccc([N+](=O)[O-])cc1,,C1CCOC1,c1ccncc1,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050228004A1,Cc1cc(Br)cn2c(-c3ccnc(NC4CCCC4)n3)c(-c3ccc(F)cc3)nc12>>Cc1cccn2c(-c3ccnc(NC4CCCC4)n3)c(-c3ccc(F)cc3)nc12,[Pd],CCO,,,,val
US05792788,COc1ccc(Cl)cc1C(=O)NCCc1sc(S(N)(=O)=O)cc1C.N#CO[K]>>COc1ccc(Cl)cc1C(=O)NCCc1sc(S(=O)(=O)NC(N)=O)cc1C,,CCN(CC)CC,,,,val
US20070099990A1,CC(C)c1ccc(C=O)cc1.Cc1c(Br)c2c(c(C)c1NC(=O)OC(C)(C)C)CC(C)(C)O2>>Cc1c2c(c(C(O)c3ccc(C(C)C)cc3)c(C)c1NC(=O)OC(C)(C)C)OC(C)(C)C2,,C1CCOC1,,O,[Li]CCCC,val
US20090099207A1,CC(C)(C)OC(=O)N(Cc1cccc(C(C)(C)C)c1)[C@H]1CS(=O)(=O)C[C@@H](Cc2ccc(N/C(S)=C/C(=O)c3ccc(F)cc3)cc2)[C@@H]1O.CI>>CS/C(=C\C(=O)c1ccc(F)cc1)Nc1ccc(C[C@@H]2CS(=O)(=O)C[C@H](N(Cc3cccc(C(C)(C)C)c3)C(=O)OC(C)(C)C)[C@H]2O)cc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20030073697A1,CC=Cc1c(N)ccc2c1O[C@@H](COS(=O)(=O)c1ccc(C)cc1)CO2.COC(=O)Cl>>C=C(C)c1c(NC(=O)OC)ccc2c1OC(COS(=O)(=O)c1ccc(C)cc1)CO2,,CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US20120004166A1,CC#CC(CC(=O)OC)c1ccc(O)cc1.CC(CO)CO>>CC#CC(CC(=O)OC)c1ccc(OCC(C)CO)cc1,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100130495A1,CC(=O)N1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(OS(=O)(=O)C(F)(F)F)c2C1.CNCc1cccnc1>>CC(=O)N1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(N(C)Cc3cccnc3)c2C1,,CS(C)=O,,,,val
US20150057279A1,Cc1ccnc(N(CCNS(=O)(=O)/C=C/C(F)(F)F)C(=O)OC(C)(C)C)c1>>Cc1ccnc(NCCNS(=O)(=O)/C=C/C(F)(F)F)c1,,C1COCCO1,,Cl,,val
US04668823,Br[Mg]c1ccccc1.CC(C)C[Mg]I.ClP(Cl)c1ccccc1>>CC(C)CP(c1ccccc1)c1ccccc1,,CCOCC,,,,val
US05776658,C=C[Si](OCC)(OCC)OCC.CCC(Cc1ccccc1)(C(=O)c1ccc(N2CCOCC2)cc1)N(C)C>>CCO[Si](CCc1cc(N2CCOCC2)ccc1C(=O)C(CC)(Cc1ccccc1)N(C)C)(OCC)OCC,,Cc1ccccc1,,,,val
US04853389,CSc1ncc(S(=O)(=O)NC(C)(C)C)c(Nc2cccc(C)c2)n1>>CSc1ncc(S(N)(=O)=O)c(Nc2cccc(C)c2)n1,,O=C(O)C(F)(F)F,,,,val
US05849801,CC1=CC(N2CCC3(CC2)OCCO3)C(O)C(C)(C)CC1=O>>CC1=CC(N2CCC(=O)CC2)C(O)C(C)(C)CC1=O,,CCO,,Cl,,val
US20070299062A1,COC(=O)c1sc(Br)cc1N=CN(C)C.N[C@H]1CCc2cc(CO)ccc2C1>>O=c1c2sc(Br)cc2ncn1[C@H]1CCc2cc(CO)ccc2C1,,CCO,,CCN(C(C)C)C(C)C,,val
US20050228155A1,CCC(CC)=C1C=CC=C1.[Li]C>>CCC(C)(CC)C1=CC=CC1,,CCOCC,,O,,val
US20050203081A1,COC(=O)COc1c(C(=O)OC)sc2cc(C(=O)O)ccc12.O=C(n1ccnc1)n1ccnc1>>COC(=O)COc1c(C(=O)OC)sc2cc(C(N)=O)ccc12,,C1CCOC1,,,,val
US20050131216A1,COCCOCCl.O=Cc1cc(O)ccc1[N+](=O)[O-]>>COCCOCOc1ccc([N+](=O)[O-])c(C=O)c1,,ClCCl,,C1CCOC1,CCN(C(C)C)C(C)C,val
US20150111891A1,Cc1cc2ccccc2c(Cl)c1[C@H](O)CO.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cc1cc2ccccc2c(Cl)c1[C@H](O)COC(c1ccccc1)(c1ccccc1)c1ccccc1,,ClCCl,,c1ccncc1,,val
US06403601B1,COc1c(C(N)=O)cc2c(c1I)CCCC2>>COc1c(C#N)cc2c(c1I)CCCC2,,C1CCOC1,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20120095016A1,CN=C=O.O=c1c2c[nH]c3[nH]ccc3c-2nn1-c1ccccc1>>CNC(=O)n1ccc2c3nn(-c4ccccc4)c(=O)c-3c[nH]c21,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05480873,COc1ccc(OC)c(C(=O)O)c1C(=O)O>>COc1ccc(OC)c2c1C(=O)OC2=O,,c1ccncc1,,CC(=O)OC(C)=O,,val
US06583148B1,CCOC(=O)CBr.CCc1ccc(O)cc1>>CCOC(=O)COc1ccc(CC)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090069328A1,C#Cc1ccc(OC(F)(F)F)c(C(=O)NC(C)(Cc2c[nH]c3ccccc23)C(=O)OC)c1>>C#Cc1ccc(OC(F)(F)F)c(C(=O)NC(C)(CO)Cc2c[nH]c3ccccc23)c1,,C1CCOC1,,[BH4-].[Li+],,val
US20060106032A1,CCOC(=O)c1ccc(-c2c3ccccc3nn2Cc2ccccc2)cc1>>O=C(O)c1ccc(-c2c3ccccc3nn2Cc2ccccc2)cc1,,[Na+],[OH-],Cl,,val
US05948782,CCOC(=O)c1c(CCl)nc2cc(OC)c(OC)cc2c1-c1ccc(OC)c(OC)c1.Cc1cccc(O)n1>>CCOC(=O)c1c(COc2cccc(C)n2)nc2cc(OC)c(OC)cc2c1-c1ccc(OC)c(OC)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04244953,Cc1nnc2ccc(-c3ccc([N+](=O)[O-])cc3)cn12>>Cc1nnc2n1CC(c1ccc(N)cc1)CC2,[Pd],,,[H][H],,val
US20140350268A1,CCCCC.CCCCCO[C@H]1[C@@H]2O[C@H]3O[C@H](COC)[C@@H](O[C@H]4O[C@H](COC)[C@@H](O[C@H]5O[C@H](COC)[C@@H](O[C@H]6O[C@H](COC)[C@@H](O[C@H]7O[C@H](COC)[C@@H](O[C@H]8O[C@H](COC)[C@@H](O[C@H]9O[C@H](COC)[C@@H](O[C@@H](O[C@@H]2COC)[C@@H]1OCCCCC)[C@H](OCCCCC)[C@H]9OCCCCC)[C@H](OCCCCC)[C@H]8OCCCCC)[C@H](OCCCCC)[C@H]7OCCCCC)[C@H](OCCCCC)[C@H]6OCCCCC)[C@H](OCCCCC)[C@H]5OCCCCC)[C@H](OCCCCC)[C@H]4OCCCCC)[C@H](OCCCCC)[C@H]3OCCCCC>>C1CCC2(CCCCO2)OC1,,CCCCC,,,,val
US04476321,N.O=S(=O)(Cl)c1ccccc1OC(F)F>>NS(=O)(=O)c1ccccc1OC(F)F,,ClCCl,,O,,val
US20150038437A1,CNC1Cc2cc3cc(-c4nc(OCc5ccccc5)c(C(=O)OCc5ccccc5)c(OCc5ccccc5)c4C)ccc3n2C1.Cl>>CNC1Cc2cc3cc(-c4[nH]c(=O)c(C(=O)O)c(O)c4C)ccc3n2C1.Cl,[Pd],CO,,,,val
US20160052898A1,Nc1cc(C(=O)Nc2ccc(-c3ccccc3)cc2)ccc1Br.O=C(Cl)CCl>>O=C(CCl)Nc1cc(C(=O)Nc2ccc(-c3ccccc3)cc2)ccc1Br,,ClCCl,,c1ccncc1,,val
US04778912,CCCCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCCCCCCCCCC[N+](C)(C)C)OCc1ccccc1>>CCCCCCCCCCCCCCCCCCOCC(O)COP(=O)([O-])OCCCCCCCCCC[N+](C)(C)C,[Pd],CC(=O)O,CCO,,,val
US20140235863A1,COc1ccc(C(=O)CBr)cc1OC.NC(=S)NN=Cc1cn(Cc2ccc(Cl)cc2Cl)c2ccccc12>>COc1ccc(-c2csc(NN=Cc3cn(Cc4ccc(Cl)cc4Cl)c4ccccc34)n2)cc1OC,,C1CCOC1,,,,val
US04283341,CC1(C)C2C(=O)OC(C(Cl)(Cl)Cl)C21>>CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)O,[Zn],CC(=O)O,CCOCC,O,,val
US20020165231A1,CCN(CC)S(F)(F)F.OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F>>FC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F,,ClCCl,,,,val
US20150336962A1,C[Si](C)(C)CCOCn1ncc(N)c1-c1cc(Cl)ccc1OC(F)F.O=C(Cl)c1cnn2ccc(Cl)nc12>>C[Si](C)(C)CCOCn1ncc(NC(=O)c2cnn3ccc(Cl)nc23)c1-c1cc(Cl)ccc1OC(F)F,,ClCCl,ClCCl,CCN(CC)CC,,val
US20080207654A1,BrCc1ccccc1.CCCCc1nc(CC)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1>>CCCCc1nc(CC)n(Cc2ccccc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1,,CC(=O)N(C)C,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100120706A1,ClCCBr.Nc1nc(N)c2[nH]cnc2n1>>Nc1nc(N)c2ncn(CCCl)c2n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100197674A1,O=C(Cl)C(=O)Cl.O=C(O)c1nc2ccccc2n(-c2ccc3c(c2)OCCO3)c1=O>>O=C(Cl)c1nc2ccccc2n(-c2ccc3c(c2)OCCO3)c1=O,,ClCCl,,CN(C)C=O,,val
US20050228017A1,CC(C)C(=O)Cl.COc1cc(CNCCC(=O)NOC(C)(C)C)ccc1OCc1ccccc1>>COc1cc(CN(CCC(=O)NOC(C)(C)C)C(=O)C(C)C)ccc1OCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20020133023A1,COC(=O)CCCN1CCN(C(=O)CCNC(=O)OC(C)(C)C)CC1>>COC(=O)CCCN1CCN(C(=O)CCN)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06291530B1,CC(=O)c1ccc(OCc2c(F)cccc2F)c(OCCCOC2CCCCO2)c1.CCOP(=O)(CC(=O)N(CC)CC)OCC>>CCN(CC)C(=O)/C=C(\C)c1ccc(OCc2c(F)cccc2F)c(OCCCOC2CCCCO2)c1,,C1CCOC1,,[H-].[Na+],,val
US20020002190A1,CCOC(=O)Cc1csc(NC(=O)C(CC2CCCC2)c2ccc(-c3cccc4ccccc34)cc2)n1>>O=C(Nc1nc(CCO)cs1)C(CC1CCCC1)c1ccc(-c2cccc3ccccc23)cc1,,CCOCC,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20080176870A1,COC(=O)c1cc(CBr)n2nccc2n1.Cc1c(C(=O)OC(C)(C)C)ccc2c1CCC2N>>COC(=O)c1cc(CNC2CCc3c2ccc(C(=O)OC(C)(C)C)c3C)n2nccc2n1,,CN(C)C=O,,CCN(CC)CC,,val
US20040157804A1,COc1ccc(COc2c3c(c(OC)c4cccnc24)CNC3=O)cc1.ClCc1cc(Cl)cc(Cl)c1>>COc1ccc(COc2c3c(c(OC)c4cccnc24)CN(Cc2cc(Cl)cc(Cl)c2)C3=O)cc1,,CC(=O)O,CN(C)C=O,[H-].[Na+],,val
US20150307449A1,CN(Cc1cc(-c2ccccc2F)n(S(=O)(=O)c2ccc(O)cc2)c1)C(=O)OC(C)(C)C.CN(Cc1cc(-c2ccccc2F)n(S(=O)(=O)c2ccc(OC3CCCCO3)cc2)c1)C(=O)OC(C)(C)C.CO>>CNCc1cc(-c2ccccc2F)n(S(=O)(=O)c2ccc(OCC(=O)NC)cc2)c1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100331351A1,CCOC(=O)C(C#N)C(C)(C)Cc1ccccc1>>CCOC(=O)C1=C(N)c2ccccc2CC1(C)C,,[NH4+],[OH-],O=S(=O)(O)O,,val
US20110301155A1,CC1(C)OB(c2cc(C#N)c(N)c(OCCc3ccccn3)c2)OC1(C)C.OO>>N#Cc1cc(O)cc(OCCc2ccccn2)c1N,,CO,,Cl,[Na+].[OH-],val
US20110172245A1,COc1ccc(NC(=O)c2cccc(C3(C#N)CC3)c2)cc1Oc1ccc2nc(N)sc2c1.O=C(Cl)C1CC1>>COc1ccc(NC(=O)c2cccc(C3(C#N)CC3)c2)cc1Oc1ccc2nc(NC(=O)C3CC3)sc2c1,CN(C)c1ccncc1,c1ccncc1,,O,,val
US20130338142A1,COc1cc([N+](=O)[O-])ccc1N1CCN(C)C(CF)C1>>COc1cc(N)ccc1N1CCN(C)C(CF)C1,[Pd],CCO,,,,val
US20060287344A1,CC(C)(C)OC(=O)NC1CCN(C(=O)N2CCCC2)CC1>>NC1CCN(C(=O)N2CCCC2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130129753A1,CC[C@H](C)[C@@H]([C@@H](CC(=O)OC(C)(C)C)OC)N(C)C(=O)[C@@H](N)C(C)C.CN1CCC[C@]1(C)C(=O)O>>CC[C@H](C)[C@@H]([C@@H](CC(=O)OC(C)(C)C)OC)N(C)C(=O)[C@@H](NC(=O)[C@@]1(C)CCCN1C)C(C)C,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080015191A1,COc1cc(N)cc(OC)c1OC.Clc1cncc(Oc2ccccc2-c2ccccc2)n1>>COc1cc(Nc2cncc(Oc3ccccc3-c3ccccc3)n2)cc(OC)c1OC,,CCOC(C)=O,,,,val
US20090291971A1,COC(=O)c1sc2ncnc(On3nnc4cccnc43)c2c1C.Cc1noc(C)c1B(O)O>>COC(=O)c1sc2ncnc(Oc3c(C)noc3C)c2c1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120028919A1,CS(=O)(=O)c1cccc(-c2ccc3cnc(Nc4ccc(C5=CCN(CC(N)=O)CC5)c(C(F)(F)F)c4)nn23)c1.CS(=O)(=O)c1cccc(-c2ccc3cnc(O)nn23)c1.NC(=O)CN1CC=C(c2ccc(N)cc2C(F)(F)F)CC1>>CS(=O)(=O)c1cccc(-c2ccc3cnc(Nc4ccc(C5=CCN(CC(N)=O)CC5)c(C(F)(F)F)c4)nn23)c1.O=C(O)C(F)(F)F,,CS(C)=O,,,,val
US20020156081A1,COc1cc(-c2nn([C@@H]3CC[C@@H](N4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1N.O=C(Cl)[C@@H]1C[C@H]1c1ccccc1>>COc1cc(-c2nn([C@@H]3CC[C@@H](N4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)[C@H]1C[C@@H]1c1ccccc1,,c1ccncc1,,,,val
US20130143835A1,CCCCOC(=O)[C@H](C)N.O=P(Cl)(Cl)Oc1ccccc1.O=[N+]([O-])c1ccc(O)cc1>>CCCCOC(=O)[C@H](C)NP(=O)(Oc1ccccc1)Oc1ccc([N+](=O)[O-])cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20050009982A1,C=CCCC(=O)O.C[Si](C)(C)N[Si](C)(C)C>>C=CCCC(=O)O[Si](C)(C)C,,Cc1ccccc1,,C1CCOC1,,val
US20100292188A1,C1COCCN1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.c1cc(-c2nc3c(s2)CNCC3)ccc1O[C@@H]1C[C@@H](N2CCCCC2)C1>>O=C(N1CCOCC1)N1CCc2nc(-c3ccc(O[C@@H]4C[C@@H](N5CCCCC5)C4)cc3)sc2C1,,ClCCl,,CCN(CC)CC,,val
US05696132,CC(C)(C)OC(=O)N[C@H]1CCNC1.Cc1c(F)c(F)c(F)c2c1c(=O)c(C(=O)O)cn2[C@@H]1C[C@@H]1F>>Cc1c(F)c(N2CC[C@H](N)C2)c(F)c2c1c(=O)c(C(=O)O)cn2[C@@H]1C[C@@H]1F,,CS(C)=O,,,,val
US20140256700A1,Cc1noc(C)c1-c1cc(C(N)=O)c2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1>>Cc1noc(C)c1-c1cc(C(N)=O)c2c3ccc(C(C)C)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20120245161A1,COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)C(F)(F)F)ccc3F)CC2)c2c(Cl)cccc21>>COCCn1cc(C(=O)N2CCC(c3cc(CN)ccc3F)CC2)c2c(Cl)cccc21,,CO,O,[Na+].[OH-],,val
US20120083502A1,CCc1[nH]c2ccc(F)cc2c(=O)c1I.OB(O)c1cc(F)cc(F)c1>>CCc1[nH]c2ccc(F)cc2c(=O)c1-c1cc(F)cc(F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,O,O=C([O-])[O-].[Na+].[Na+],,val
US07071175B1,CCOC(=O)C(Cc1ccc(NC(=O)OC(C)(C)C)nc1)C(CCc1ccccc1)SC(C)=O>>Nc1ccc(CC(C(=O)O)C(S)CCc2ccccc2)cn1,,Cl,,,,val
US20140303121A1,CCOC(=O)C(c1ccccc1)n1cc(-c2cnn(C)c2)c2ncc(-c3c(C)noc3C)cc21>>Cc1noc(C)c1-c1cnc2c(-c3cnn(C)c3)cn(C(C(=O)O)c3ccccc3)c2c1,,C1CCOC1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US05284847,CC(C)(C)O.CCc1c(C)sc(NC(=O)OC(C)(C)C)c1C(=O)O.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCc1c(C)sc(NC(=O)OC(C)(C)C)c1NC(=O)OC(C)(C)C,,C1CCOC1,,CCN(CC)CC,,val
US05237063,COC(=O)c1ccccc1S(=O)(=O)N=C=O.COc1cc(OC(F)(F)F)nc(N)n1>>COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC(F)(F)F)n1,,CC#N,,,,val
US20030078426A1,Cc1cc(Oc2ccc([N+](=O)[O-])c(N(C)C(=O)OC(C)(C)C)c2)cc(C)c1NC(=O)OC(C)(C)C>>Cc1cc(Oc2ccc(N)c(N(C)C(=O)OC(C)(C)C)c2)cc(C)c1NC(=O)OC(C)(C)C,[Pd],CO,,,,val
US20050038104A1,CCO.N#Cc1c(F)cc(N2CCC(O)CC2)cc1F>>CCOc1cc(N2CCC(O)CC2)cc(F)c1C#N,,CCO,,C,C[O-].[Na+],val
US05262390,COC(=O)C(C)Oc1cc(C)ccc1CCl.Cc1nn(-c2ccc(O)cc2F)c(=O)n1C(F)F>>COC(=O)C(C)Oc1cc(C)ccc1COc1ccc(-n2nc(C)n(C(F)F)c2=O)c(F)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020137782A1,CCOC(=O)C[C@@H](C)c1ccc(NC(=O)Cc2cc(C)c3nc(Nc4ccccc4C)oc3c2)cc1>>Cc1ccccc1Nc1nc2c(C)cc(CC(=O)Nc3ccc(C(C)CC(=O)O)cc3)cc2o1,,CO,O,[Na+].[OH-],,val
US05093364,CO.O=c1[nH]c2cc(F)ccc2c(=O)o1>>COC(=O)c1ccc(F)cc1N,,CO,,C[O-].[Na+],,val
US20110049444A1,CC(C)CI.CN1CCCC1=O.Cc1cccc(N)c1.Cc1ccccc1>>Cc1cccc(N(CC(C)C)CC(C)C)c1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20130046013A1,CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CC)C(=O)NCCO.O=C(Cl)OC(Cl)(Cl)Cl>>CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CC)C(=O)NCCOC(=O)Cl,,ClCCl,,CC(C)NC(C)C,,val
US04820734,O=C1CCCC[C@H]1[C@@H](C[N+](=O)[O-])c1ccc(OCc2ccccc2)cc1>>NC[C@@H](c1ccc(OCc2ccccc2)cc1)[C@@H]1CCCC[C@@H]1O,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20040029947A1,CCCC(=O)CC(=O)OCC.Cc1ccc(Br)c2c(CC(N)CO)c[nH]c12.FB(F)F>>CCCC1(CC(=O)OCC)OCCc2c1[nH]c1c(C)cc(F)c(Br)c21,,ClCCl,,CCOCC,,val
US05405851,N#Cc1ccc(N(C(=O)C(F)(F)F)c2cccc3c2CCC=C3)cc1.O=C(OO)c1cccc(Cl)c1>>N#Cc1ccc(N(C(=O)C(F)(F)F)c2cccc3c2CCC2OC32)cc1,,ClCCl,,,,val
US20150141400A1,CCSc1ccc(Cl)cc1C#N>>CCSc1ccc(Cl)cc1CN,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20150266850A1,COC(=O)NCc1cc(C#N)ccc1C.OO>>COC(=O)NCc1cc(C(N)=O)ccc1C,,CCO,,[Na+].[OH-],,val
US20150099719A1,CC(C)(C)c1nc(-c2ccc(Br)cc2)c([C@@H]2CCCC[C@H]2C(=O)O)s1.N#CC1([NH3+])CC1>>CC(C)(C)c1nc(-c2ccc(Br)cc2)c([C@@H]2CCCC[C@H]2C(=O)NC2(C#N)CC2)s1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060287382A1,CS(=O)(=O)Cl.OCCCc1ccccc1Br>>CS(=O)(=O)OCCCc1ccccc1Br,,C1CCOC1,,CCN(CC)CC,O,val
US20100190745A1,COC(=O)c1cc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)ncc1Br.N>>CC(C)(C)OC(=O)Nc1cc(C(N)=O)c(Br)cn1,,CO,,,,val
US20120295884A1,CC(=O)OC(C)=O.COC(=O)[C@@H]1CCC(=O)N1C(=O)OC(C)(C)C>>COC(=O)[C@@H]1CCC(OC(C)=O)N1C(=O)OC(C)(C)C,CN(C)c1ccncc1,C1CCOC1,Cc1ccccc1,CCN(CC)CC,,val
US20060063779A1,C1CSCCN1.Cc1nc(Cl)ccc1C(=O)Nc1ccc(Cl)c(-c2ccccn2)c1>>Cc1nc(N2CCSCC2)ccc1C(=O)Nc1ccc(Cl)c(-c2ccccn2)c1,,CCCCO,,,,val
US20060264433A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=[N+]([O-])C1CN(Cc2ccccc2)CC1c1ccc(F)cc1Cl>>CC(C)(C)OC(=O)NC1CN(Cc2ccccc2)CC1c1ccc(F)cc1Cl,[Zn],CC(=O)O,CO,CCN(C(C)C)C(C)C,,val
US20090042890A1,CCOC(=O)c1nc(N[C@@H]2CC[C@@H](O)CC2)nc(Nc2ccccc2OC)c1N.CCOC(=O)c1nc(N[C@H]2CC[C@H](O)CC2)nc(Nc2ccccc2OC)c1[N+](=O)[O-]>>COc1ccccc1-n1c(=O)[nH]c2c(C(N)=O)nc(N[C@@H]3CC[C@@H](O)CC3)nc21,[Pd],,,CCO,,val
US05210077,COC(=O)CCn1cnc2c(Cl)ncnc21>>O=C(O)CCn1cnc2c(Cl)ncnc21,,C1COCCO1,O,[Na+].[OH-],,val
US05399574,CNC.N#CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12>>CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12,[Pd],,,,,val
US20080300242A1,CCOc1cc(N2CCN(CCS(C)(=O)=O)CC2)c(C)cc1[N+](=O)[O-]>>CCOc1cc(N2CCN(CCS(C)(=O)=O)CC2)c(C)cc1N,[Pt],CCO,,,,val
US20110092526A1,COC(=O)CC(=O)C1CCC1.COC(OC)N(C)C>>COC(=O)C(=CN(C)C)C(=O)C1CCC1,,C1COCCO1,,,,val
US20070191293A1,CC(C)(C)[Si](OC[C@@H]1CC=C[C@]1(C)O)(c1ccccc1)c1ccccc1>>C[C@]1(O)C=CC[C@H]1CO,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100239219A1,Cc1ccc(OCCCCCCCCCCCNC(=O)CCSC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Cc1ccc(OCCCCCCCCCCCNC(=O)CCS)cc1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20110034455A1,COc1cc(CNC(=O)C23CC4CC(C2)C(O)C(C4)C3)cc(OC)c1.O=C(O)CC1CC2(CCNCC2)c2ccccc21.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc(CNC(=O)C23CC4CC(C2)C(OC(=O)N2CCC5(CC2)CC(CC(=O)O)c2ccccc25)C(C4)C3)cc(OC)c1,,ClCCl,,,,val
US20080305075A1,CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@@H]3[C@]45CCN4CC=C[C@](CC)([C@H]45)[C@@H](OC(C)=O)[C@]3(O)C(=O)OC)C2)C1>>CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@@H]3[C@]45CCN4CC=C[C@](CC)([C@H]45)[C@@H](OC(C)=O)[C@]3(O)C(=O)OC)C2)C1,,ClCCl,,O=S(=O)(O)O,O=C([O-])[O-].[Na+].[Na+],val
US20030096826A1,BrCc1ccccc1.COC(=O)c1ccc([N+](=O)[O-])c(O)c1>>COC(=O)c1ccc([N+](=O)[O-])c(OCc2ccccc2)c1,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06107291,CCOC(=O)C=CC1CCCCN(S(=O)(=O)c2ccc(OC)cc2)C1C(=O)NO>>COc1ccc(S(=O)(=O)N2CCCCC(C=CC(=O)O)C2C(=O)NO)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20130143870A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1nc2c(s1)CNCC2>>CC(C)(C)OC(=O)N1CCc2nc(N)sc2C1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US05804588,BrBr.COc1c(F)ccc2cccnc12>>COc1c(F)cc(Br)c2cccnc12,,CC(=O)O,,,,val
US04032527,CCN(CC)c1cccc(N(CC)CC)c1.CN(C)c1ccc(C(=O)c2c(Cl)c(Cl)c(Cl)c(Cl)c2C(=O)O)cc1>>CCN(CC)c1ccc(C2(c3ccc(N(C)C)cc3)OC(=O)c3c(Cl)c(Cl)c(Cl)c(Cl)c32)c(N(CC)CC)c1,,CO,,CC(=O)OC(C)=O,,val
US20140179690A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1=N[C@@]2(c3cc([N+](=O)[O-])cc(F)c3F)CO[C@H](C(F)F)[C@H]2CS1>>CC(C)(C)OC(=O)NC1=N[C@@]2(c3cc([N+](=O)[O-])cc(F)c3F)CO[C@H](C(F)F)[C@H]2CS1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20090298807A1,CC(C)(C)[Si](C)(C)O[C@@H](CN)c1ccc(O)c2[nH]c(=O)ccc12.Cc1nc(C(=O)N2CCOC3(CCN(CCCOc4cccc(C=O)c4)CC3)C2)cs1>>Cc1nc(C(=O)N2CCOC3(CCN(CCCOc4cccc(CNC[C@H](O[Si](C)(C)C(C)(C)C)c5ccc(O)c6[nH]c(=O)ccc56)c4)CC3)C2)cs1,,CO,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05478858,Cc1c(N)ccc2c1ncn2C.S=C(Oc1ccccn1)Oc1ccccn1>>Cc1c(N=C=S)ccc2c1ncn2C,CN(C)c1ccncc1,ClCCl,,,,val
US20100029671A1,O=S(Cl)Cl.O=c1cc(CO)oc2ccccc12>>O=c1cc(CCl)oc2ccccc12,,ClC(Cl)Cl,,,,val
US20060063762A1,CCC(=O)Nc1cccc2c(C[C@@H](C)N3C[C@@H](c4cccc(Cl)c4)OC3=O)c[nH]c12>>CCC(=O)Nc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12,,CCO,,[Na+].[OH-],,val
US20120196863A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C1COCC(c2ccc(OC(F)F)nc2)(c2cccc(Br)c2)N1>>FC(F)Oc1ccc(C2(c3cccc(Br)c3)COCC(=S)N2)cn1,,C1CCOC1,,,,val
US20120245137A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@H](Sc2cccc(C(F)(F)F)c2)CC1.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1,,CO,ClCCl,O,O=C([O-])O.[Na+],val
US20080004269A1,CCCc1c(Cl)ncnc1Cc1ccnn1-c1ncccc1F.CCN>>CCCc1c(Cc2ccnn2-c2ncccc2F)ncnc1NCC,,CCO,,,,val
US20040053942A1,Fc1ccc(-c2nn3ccccc3c2-c2ccnc(F)c2)cc1.NCCc1c[nH]cn1>>Fc1ccc(-c2nn3ccccc3c2-c2ccnc(NCCc3cnc[nH]3)c2)cc1,,CCOC(C)=O,,,,val
US20040167160A1,CCOc1c(-c2cnc3ccc(C(=O)OC)cn23)cc(C(C)C)cc1C(C)C>>CCOc1c(-c2cnc3ccc(CO)cn23)cc(C(C)C)cc1C(C)C,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US20100249099A1,CN(C)CCNS(=O)(=O)C1CCN(C(=O)OCc2ccccc2)CC1.COc1cccc2c1nc(C(F)F)n2-c1nc(Cl)nc(N2CCOCC2)n1>>COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCC(S(=O)(=O)NCCN(C)C)CC2)n1,[Pd],C1CCOC1,CO,CCN(C(C)C)C(C)C,,val
US20140309213A1,CC(C)(C)OC(=O)N1CCNCC1.O=CCc1ccc2c(c1)CCOC2=O>>CC(C)(C)OC(=O)N1CCN(CCc2ccc3c(c2)CCOC3=O)CC1,,ClCCl,,O=C([O-])O.[Na+],,val
US20030078249A1,COc1cc(CC(=O)OC(C)(C)C)ccc1NC(=O)Nc1ccccc1OCc1ccccc1>>COc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1OCc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160251339A1,COc1ccc(S(=O)(=O)n2cc(C(F)F)c3cc(F)ccc32)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1>>COc1ccc(S(=O)(=O)n2cc(C(F)F)c3cc(F)ccc32)cc1N1CCNCC1,,C1CCOC1,,[K+].[OH-],,val
US06653334B1,C=CCOC(=O)c1cccc(OC(C)(C)C(=O)OC(C)(C)C)c1>>C=CCOC(=O)c1cccc(OC(C)(C)C(=O)O)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020040020A1,CC(C)(C)OC(=O)N1CCN(c2c([N+](=O)[O-])cccc2[N+](=O)[O-])CC1.CS(=O)(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2CC2CO2)C1>>CS(=O)(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2CC(O)CN2CCN(c3c([N+](=O)[O-])cccc3[N+](=O)[O-])CC2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US09115114B2,COc1cc(OCC2CC2)c(Br)cn1>>Oc1cc(OCC2CC2)c(Br)cn1,,CN(C)C=O,O,[Cl-].[Li+],,val
US05852014,O=C(NCC1CCN(Cc2ccccc2)CC1)c1c[nH]c2ccccc12.OCCCBr>>O=C(NCC1CCN(Cc2ccccc2)CC1)c1c2n(c3ccccc13)CCCO2,,ClC(Cl)Cl,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20090281092A1,CC1(F)CN(C2CCCC2)c2nc(Cl)ncc2NC1=O.CI>>CN1C(=O)C(C)(F)CN(C2CCCC2)c2nc(Cl)ncc21,,CC(=O)N(C)C,,[H-].[Na+],,val
US20100249163A1,COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(O)c2c[nH]nn2)C2CC2)cc(OCCOC)c1>>COCCCc1cc(CN(C(=O)C2CNCCC2(O)c2c[nH]nn2)C2CC2)cc(OCCOC)c1,,ClCCl,,Cl,,val
US20040167194A1,Cc1c([N+](=O)[O-])cc(C(=O)O)c2nc[nH]c12.NS(N)(=O)=O>>Cc1c([N+](=O)[O-])cc(C(N)=O)c2nc[nH]c12,,O,,c1ccncc1,,val
US20150045349A1,CC(=O)CC(=O)N[C@@H](C)C(C)C.COC(OC)N(C)C>>CC(=O)C(=CN(C)C)C(=O)N[C@@H](C)C(C)C,,CN(C)C=O,,,,val
US20110218192A1,CCOC1=NC(=O)C2(CC(C)(C)Oc3ccc(Br)cc32)N1.N>>CC1(C)CC2(NC(N)=NC2=O)c2cc(Br)ccc2O1,,CCO,,O,,val
US20140200344A1,BrBr.c1cnc2c(c1)CCN2>>Brc1cnc2c(c1)CCN2,,ClCCl,c1ccncc1,O=S([O-])([O-])=S.[Na+].[Na+],,val
US04075225,O=C1c2ccccc2CCn2c1cc(Br)c2Br>>O=C1c2ccccc2CCn2cccc21,[Pd],CCN(CC)CC,,CCO,[H][H],val
US20110263602A1,CNC1CCN(c2nnc(-c3ccc(C#N)cc3)c(C)c2C)CC1.Cl.N#Cc1ccc(C(=O)Cl)cc1>>Cc1c(-c2ccc(C#N)cc2)nnc(N2CCC(N(C)C(=O)c3ccc(C#N)cc3)CC2)c1C.Cl,,CO,ClCCl,CCN(CC)CC,,val
US20130261116A1,CNC(=O)c1ccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1F.COc1ccc(B(O)O)cc1>>COc1ccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1,,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20140134110A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#CCCOCC(N)(COCCC#N)COCCC#N>>CC(C)(C)OC(=O)NC(COCCC#N)(COCCC#N)COCCC#N,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20050203153A1,CCCNc1ccc([N+](=O)[O-])cc1-c1nc2cc(-c3cc4ccccc4o3)ccc2o1>>CCCNc1ccc(N)cc1-c1nc2cc(-c3cc4ccccc4o3)ccc2o1,[Zn],,,,,val
US20160176850A1,COc1ccnc2[nH]nc(C3CCN(c4nc(Cl)nc(OC[C@H]5C[C@H]5C#N)n4)CC3)c12.N#CCC#N>>COc1ccnc2[nH]nc(C3CCN(c4nc(OC[C@H]5C[C@H]5C#N)nc(C(C#N)C#N)n4)CC3)c12,,CC#N,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20060257987A1,CCc1ccc(O)c(-c2ccccc2)c1.CN(C)C=O.COC(=O)CCc1ccc(OCC[C@H](C)OS(C)(=O)=O)cc1>>CCc1ccc(OC(C)CCOc2ccc(CCC(=O)OC)c(C)c2)c(-c2ccccc2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06180622B2,C=CCOC(=O)C1=C(S[C@H]2C[C@@H](Cc3cn4c(C)ncc4s3)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12.CC(=O)OCCBr>>C=CCOC(=O)C1=C(S[C@H]2C[C@@H](Cc3c[n+]4c(C)n(CC(=O)OCC)cc4s3)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12.[Br-],,CC(C)=O,,,,val
US20040029888A1,CN(C)CCOCc1ncccc1OCCOC1CCCCO1>>CN(C)CCOCc1ncccc1OCCO,,CC(=O)O,,,,val
US20140288123A1,Cc1cc(C)c(CN)c(O)n1.O=C(O)c1ccc(C2CCCO2)cc1>>Cc1cc(C)c(CNC(=O)c2ccc(C3CCCO3)cc2)c(O)n1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160052930A1,Cn1cc(Nc2nccc(N3C[C@@H]4CC[C@H](C3)N4)n2)cn1.N#CCNC(=O)n1ccnc1>>Cn1cc(Nc2nccc(N3C[C@@H]4CC[C@H](C3)N4C(=O)NCC#N)n2)cn1,,CCO,,CCN(CC)CC,Cl,val
US20120094964A1,N#Cc1ccc(S(=O)(=O)N(Cc2ccccc2)c2ncc(C(F)(F)F)cc2Cl)cc1>>NCc1ccc(S(=O)(=O)N(Cc2ccccc2)c2ncc(C(F)(F)F)cc2Cl)cc1,[Ni],CO,N,,,val
US20040072865A1,CCOC(CCCN)OCC.O=C1OC(=O)c2ccccc21>>CCOC(CCCN1C(=O)c2ccccc2C1=O)OCC,,Cc1ccccc1,,,,val
US20120258950A1,CNc1cncc(C(=O)c2cn(C(C)C)c3ncncc23)c1.O=C(O)Cc1ccc(Cl)cc1>>CC(C)n1cc(C(=O)c2cncc(N(C)C(=O)Cc3ccc(Cl)cc3)c2)c2cncnc21,,c1ccncc1,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20110059118A1,CC(C)CS(=O)(=O)Cl.CSc1ncc(Br)c(N[C@H]2CCCNC2)n1>>CSc1ncc(Br)c(N[C@H]2CCCN(S(=O)(=O)CC(C)C)C2)n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120308588A1,CC1=NN(c2ccc(C(=O)O)cc2)C(=O)C1.CCOC(=O)[C@H](O)[C@H](N)Cc1ccccc1Cl>>CCOC(=O)[C@H](O)[C@@H](Cc1ccccc1Cl)NC(=O)c1ccc(N2N=C(C)CC2=O)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130190316A1,CC(C)n1nccc1-c1ncccc1COc1cncc(O)c1CO>>CC(C)n1nccc1-c1ncccc1COc1cncc(O)c1C=O,O=[Mn]=O,CC#N,,,,val
US20100197651A1,CI.COc1cn(-c2ccc(N3CCNC3=O)cc2F)nc(-c2ccnn2-c2ccccc2)c1=O>>COc1cn(-c2ccc(N3CCN(C)C3=O)cc2F)nc(-c2ccnn2-c2ccccc2)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20160222030A1,COc1cccc(OC)c1C(=O)Cl.N[C@@H]1CCC[C@@H]1Nc1nc2ccc(Cl)cc2s1>>COc1cccc(OC)c1C(=O)N[C@@H]1CCC[C@@H]1Nc1nc2ccc(Cl)cc2s1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20060014797A1,BrCc1ccccc1.OCCc1sc2ccccc2c1Br>>Brc1c(CCOCc2ccccc2)sc2ccccc12,,CN(C)C=O,,[H-].[Na+],,val
US05583235,CC(C)(C)[Si](C)(C)OCC1=CC=C(CO)SS1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)[Si](C)(C)OCC1=CC=C(CN=[N+]=[N-])SS1,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,,val
US20070244119A1,C=C[C@H]1CCCN1C(=O)OC(C)(C)C>>CC[C@H]1CCCN1C(=O)OC(C)(C)C,[Pd],CO,,[H][H],,val
US20110077243A1,CNC(=O)c1cn2cc(-c3cnc(N(C(=O)OC(C)(C)C)C(C)C)s3)cc(-c3ccccc3)c2n1>>CNC(=O)c1cn2cc(-c3cnc(NC(C)C)s3)cc(-c3ccccc3)c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05180418,COC(=O)C1(Sc2cc(N)c(F)cc2Cl)CCC1.O=C1CC(C(F)(F)F)CC(=O)O1>>COC(=O)C1(Sc2cc(NC(=O)CC(CC(=O)O)C(F)(F)F)c(F)cc2Cl)CCC1,,c1ccccc1,,,,val
US20100204196A1,C=CC(=O)N1CCCc2cc(OC)c([N+](=O)[O-])cc21.CNC>>COc1cc2c(cc1[N+](=O)[O-])N(C(=O)CCN(C)C)CCC2,,CO,,,,val
US20110098481A1,Cc1cccc([C@@H](C)[C@H](O)/C=C/[C@H]2[C@H](OC(=O)c3ccccc3)C[C@@H]3OC(=O)C[C@@H]32)c1>>Cc1cccc([C@@H](C)[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H]3OC(=O)C[C@@H]32)c1,,CO,,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US20110144084A1,O=C(O)c1cncc(Cl)n1.O=S(Cl)Cl>>O=C(Cl)c1cncc(Cl)n1,,CC#N,,,,val
US20090318690A1,BrCC1OCCO1.OCc1c(OCc2ccc(F)cc2)ccc2c(CCC3CCNCC3)noc12>>OCc1c(OCc2ccc(F)cc2)ccc2c(CCC3CCN(CC4OCCO4)CC3)noc12,,O,,CN(C)C=O,O=C([O-])O.[Na+],val
US20030119842A1,CC(=O)Cl.Cc1cccc(N)n1.O=Cc1ccccn1.[C-]#[N+]C1CCCCC1>>CC(=O)[n+]1c(-c2ccccn2)c(NC2CCCCC2)n2c(C)cccc21.[Cl-],,[O-][Cl+3]([O-])([O-])O,,,,val
US05840732,Cl.O=C1OC(=CCCc2ccccc2)C(=O)N1CCCCOc1cccn2ccnc12>>Cl.O=C1OC(=CCCc2ccccc2)C(=O)N1CCCCOc1cccn2ccnc12,,CO,,CCOC(C)=O,,val
US20100227866A1,Cc1ccc(COC(=O)c2ccccc2)cn1.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(COC(=O)c2ccccc2)c[n+]1[O-],,ClC(Cl)Cl,,O=C([O-])[O-].[K+].[K+],,val
US20090028925A1,COc1cc(C)c(Br)c(C)c1C>>Cc1cc(O)c(C)c(C)c1Br,,CC(=O)O,,Br,,val
US04461907,O=C(C=Cc1ccc(Cl)cc1)c1cc(Cl)ccc1O>>Clc1ccc(C2C=Cc3cc(Cl)ccc3O2)cc1,,CCO,,[BH4-].[Na+],,val
US20040138251A1,COc1cc(N)c(Cl)cc1Cl.N#Cc1cnc2cc(-c3ccccc3)sc2c1Cl>>COc1cc(Nc2c(C#N)cnc3cc(-c4ccccc4)sc23)c(Cl)cc1Cl,,C1CCOC1,,[H-].[Na+],,val
US20030017182A1,C(=NC1CCCCC1)=NC1CCCCC1.COc1ccc(C(=O)O)cc1.Oc1ccccc1>>C=CCCOc1ccc(OC(=O)c2ccc(OC)cc2)cc1,,,,,,val
US06281357B1,C=CCn1cc(C[C@H]2CCCN2C)c2cc(C(C#N)S(=O)(=O)N(C)C(c3ccccc3)c3ccccc3)ccc21>>C=CCn1cc(C[C@H]2CCCN2C)c2cc(CS(=O)(=O)N(C)C(c3ccccc3)c3ccccc3)ccc21,,CCO,,[K+].[OH-],,val
US04332808,CCBr.OC1(c2cccc3[nH]ccc23)CCCNC1>>CCN1CCCC(O)(c2cccc3[nH]ccc23)C1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US05665271,CC[Mg]Br.Fc1cc([C@@H]2CC[C@@H](CCCCC3CC[SiH](Cl)CC3)CC2)ccc1OC(F)F>>CC[Si@@H]1CC[C@@H](CCCC[C@@H]2CC[C@@H](c3ccc(OC(F)F)c(F)c3)CC2)CC1,,C1CCOC1,,,,val
US20100168418A1,CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCN(CCn2c(=O)cc(Cl)c3ccccc32)CC1>>O=c1cc(Cl)c2ccccc2n1CCN1CCC(NCc2ccc3c(c2)OCCO3)CC1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20070093476A1,O=[N+]([O-])c1ccc(F)cc1O.[OH-]>>O=[N+]([O-])c1ccc(O)cc1O,,O,,Cl,,val
US20030130522A1,CC(C)[Si](O[C@@H](CO)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)(C(C)C)C(C)C>>CC(C)[Si](O[C@@H](CO)[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C)(C(C)C)C(C)C,,CO,,,,val
US20160185764A1,C[C@H]1[C@H](/C=C/c2ccc(Br)cn2)[C@@H]2[C@@H](C)OC(=O)[C@]2(N2CC(C#N)C2)CC1(F)F.OO>>C[C@H]1[C@H](/C=C/c2ccc(Br)cn2)[C@@H]2[C@@H](C)OC(=O)[C@]2(N2CC(C(N)=O)C2)CC1(F)F,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040059128A1,Cn1nc(-c2ccc(Cl)cc2F)cc1O.FC(F)Cl>>Cn1nc(-c2ccc(Cl)cc2F)cc1OC(F)F,,C1COCCO1,O,[Na+].[OH-],,val
US20130065900A1,CC(C)(C)OC(=O)N(CCc1ccc([N+](=O)[O-])cc1)Cc1ccccc1>>CC(C)(C)OC(=O)N(CCc1ccc(N)cc1)Cc1ccccc1,,C1CCOC1,,,,val
US20150038473A1,C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)([O-])O.[Na+]>>C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)([O-])O.[Na+],,O,,,,val
US20090227817A1,CCBr.CCOc1c(O)cccc1F>>CCOc1cccc(F)c1OCC,,ClCCl,,CCO,[Na+].[OH-],val
US04038280,CC1(C)CC(c2ccc(O)cc2)CC(C)(C)N1.CCCCBr>>CCCCOc1ccc(C2CC(C)(C)NC(C)(C)C2)cc1,,CCO,,[Na+].[OH-],,val
US20110028726A1,CC1CNc2c(cccc2S(=O)(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CC[C@@H](C)C[C@@H]2C(=O)O)C1>>CC1CNc2c(cccc2S(=O)(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CC[C@@H](C)C[C@@H]2C(=O)O)C1,,O,,,,val
US20100216746A1,C#CC1CC1.O=C(NCc1ccc(Cl)c(Oc2cc(Cl)cc(Br)c2)c1F)c1[nH]cnc1Cl>>O=C(NCc1ccc(Cl)c(Oc2cc(Cl)cc(C#CC3CC3)c2)c1F)c1[nH]cnc1Cl,[Cu]I,C1CCOC1,,,,val
US04959366,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc([N+](=O)[O-])cc1>>CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(N)cc1,[Ni],CCO,,[H][H],,val
US04167638,COc1cc([N+](=O)[O-])c2nc(Cl)ccc2c1.OCc1ccc(Cl)cc1>>COc1cc([N+](=O)[O-])c2nc(OCc3ccc(Cl)cc3)ccc2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100160308A1,CN1CCNCC1.NC(=O)c1sc(-n2cnc3ccc(OCCCCCl)cc32)nc1-c1cccc(Cl)c1>>CN1CCN(CCCCOc2ccc3ncn(-c4nc(-c5cccc(Cl)c5)c(C(N)=O)s4)c3c2)CC1,,CN(C)C=O,,[I-].[K+],,val
US20130090341A1,CCOC(=O)c1c(-c2ccncc2)n[nH]c1C>>Cc1[nH]nc(-c2ccncc2)c1C(=O)O,,CCO,,O,[Na+].[OH-],val
US05712267,C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(S[C@H]3C[C@@H](C(=O)N4CCN(C(=O)OCc5ccc([N+](=O)[O-])cc5)C(C)(C)C4)N(C(=O)OCc4ccc([N+](=O)[O-])cc4)C3)[C@H](C)[C@H]12.Cl>>C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)N4CCNC(C)(C)C4)C3)[C@H](C)[C@H]12.Cl,,C1CCOC1,O,,,val
US20070027071A1,C=CCC(C)(C)CO.CC(C)(C)[C@H](N)C(=O)O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C=CCC(C)(C)COC(=O)N[C@H](C(=O)O)C(C)(C)C,,C1COCCO1,,CCN(C(C)C)C(C)C,[Na+].[OH-],val
US20100204265A1,O=Cc1c(C(=O)N2CC=C(c3nccs3)C2)nc2c(C(F)(F)F)cc(-c3ccoc3)cn12>>O=C(c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1CO)N1CC=C(c2nccs2)C1,,CO,,[BH4-].[Na+],,val
US20160244451A1,C=CCn1cc(-c2ccc(S(=O)(=O)Nc3cc(F)c(C(=O)OC)cc3F)cc2)cnc1=O>>C=CCn1cc(-c2ccc(S(=O)(=O)Nc3cc(F)c(C(=O)O)cc3F)cc2)cnc1=O,,CO,,Cl,[Li+].[OH-],val
US20030229228A1,CCS(=O)(=O)N[C@H](C(=O)NCCc1cc(Br)c(OCc2ccccc2)c(OC)c1)C(C)C>>CCS(=O)(=O)N[C@H](C(=O)NCCc1cc(Br)c(O)c(OC)c1)C(C)C,[Pd],C1CCOC1,,,,val
US05430043,C[C@H](NCCCBr)C(=O)O.N#Cc1ccc(N=C=O)cc1>>N#Cc1ccc(NC(=O)NCCCBr)cc1,,CCOC(C)=O,ClCCl,Br,CCN(CC)CC,val
US20120115862A1,COc1ccc2c(c1)C(=O)c1ccc(Nc3ccccc3)cc1CC2>>O=C1c2ccc(Nc3ccccc3)cc2CCc2ccc(O)cc21,,CC(=O)O,,Br,,val
US20160137636A1,COc1cc(Br)c(Cl)cc1B1OC(C)(C)C(C)(C)O1.O=S(=O)(Oc1c(F)c(F)c(F)c(F)c1F)c1ccc2c(Cl)nccc2c1>>COc1cc(Br)c(Cl)cc1-c1nccc2cc(S(=O)(=O)Oc3c(F)c(F)c(F)c(F)c3F)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20160159773A1,CC(=O)OC(C)=O.Cc1ccc(C)n1-c1cc(CN)n(C)n1>>CC(=O)NCc1cc(-n2c(C)ccc2C)nn1C,CN(C)c1ccncc1,CC(=O)OC(C)=O,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20080004321A1,CCCc1c(OCc2cccc(N)c2)ccc(C(C)=O)c1O.N#Cc1cccc(S(=O)(=O)Cl)c1>>CCCc1c(OCc2cccc(NS(=O)(=O)c3cccc(C#N)c3)c2)ccc(C(C)=O)c1O,,ClCCl,,c1ccncc1,,val
US20080027065A1,C[C@H]1CN(Cc2ccc(N(C)C(=O)c3cccc(Cl)n3)cc2)CCN1C(=O)OC(C)(C)C.OB(O)c1cccc(F)c1>>C[C@H]1CN(Cc2ccc(N(C)C(=O)c3cccc(-c4cccc(F)c4)n3)cc2)CCN1C(=O)OC(C)(C)C,,ClCCl,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20120289526A1,CC(C)(C)OC(=O)NC(C)(C)C(=O)O.Nc1ccc(Oc2cccc3c2C2(CC2)CO3)nc1>>CC(C)(C)OC(=O)NC(C)(C)C(=O)Nc1ccc(Oc2cccc3c2C2(CC2)CO3)nc1,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20110213143A1,CCOc1ccc2c(c1)CCc1c(CC(CCCNC(=O)OC(C)(C)C)C(=O)O)ncn1-2>>CCOc1ccc2c(c1)CCc1c(CC(CCCN)C(=O)O)ncn1-2,,CCOC(C)=O,,Cl,,val
US20080269220A1,CCCC(Cc1nc(-c2ccccc2)cs1)c1ccc(CO)cc1.CCOC(=O)CCc1ccc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])cc1F>>CCCC(Cc1nc(-c2ccccc2)cs1)c1ccc(CN(c2ccc(CCC(=O)OCC)c(F)c2)S(=O)(=O)c2ccccc2[N+](=O)[O-])cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150005300A1,BrCc1ccccc1.O=CC1(Br)C=C(O)C=CC1>>O=Cc1cc(OCc2ccccc2)ccc1Br,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US05177088,Cl.Fc1cnccc1Cl.Nc1c[nH]c2ccccc12>>Cl.Fc1cnccc1Nc1c[nH]c2ccccc12,,CN1CCCC1=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20080221161A1,COc1ccc2cc(CCCl)c(-c3ccsc3)nc2c1.NCCc1ccc(Br)cc1>>COc1ccc2cc(CCNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1,,CCO,,,,val
US20120283264A1,COc1cccc([C@@H](O)[C@H](NC(=O)OC(C)(C)C)c2cccc(Br)n2)c1>>COc1cccc([C@H]2OC(=O)N[C@@H]2c2cccc(Br)n2)c1,,O=C(O)C(F)(F)F,,O=C(n1ccnc1)n1ccnc1,,val
US20050065170A1,COCCOCCOc1cccc(C=O)c1.O=C(O)CC(=O)O>>COCCOCCOc1cccc(C=CC(=O)O)c1,,c1ccncc1,,C1CCNCC1,,val
US20140057894A1,COc1ccc(-c2nn3ccc(Br)cc3c2/C=C/C=[N+](C)C)cc1.O>>COc1ccc(-c2nn3ccc(Br)cc3c2/C=C/C=O)cc1,,CO,,O=C([O-])O.[K+],,val
US20120157434A1,O=C(Cl)Cl.O[C@@H](Cn1ccnn1)C1Cc2cc(Br)ccc2N1>>O=C1O[C@@H](Cn2ccnn2)C2Cc3cc(Br)ccc3N12,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US20130085164A1,COc1ccc(-c2ccc(C(C)Br)nc2)cc1.c1c[nH]cn1>>COc1ccc(-c2ccc(C(C)n3ccnc3)nc2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040157859A1,COc1ccc(C2CC(=O)N(c3cccc(N)c3)C2)cc1OC1CCCC1.COc1cccc(S(=O)(=O)Cl)c1>>COc1cccc(S(=O)(=O)Nc2cccc(N3CC(c4ccc(OC)c(OC5CCCC5)c4)CC3=O)c2)c1,,ClCCl,c1ccncc1,,,val
US04489089,BrCc1ccccc1.O=C(NCCCn1ccnc1)c1cccs1>>O=C(c1cccs1)N(CCCn1ccnc1)Cc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20110282075A1,CC(C)C[C@H](C)C[C@H](C)CO.O=C1CCC(=O)N1Br>>CC(C)C[C@H](C)C[C@H](C)CBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120136176A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.O=C(Nc1ccccc1)[C@H]1CCCN1>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C(=O)Nc1ccccc1,,C1CCOC1,,CCN=C=NCCCN(C)C,Cl,val
US20070269664A1,Cc1nc2cccc(F)c2[nH]1.NOS(=O)(=O)O>>Cc1nc2c(F)cccc2n1N,,O,,C1CCOC1,,val
US20070167433A1,COC(=O)c1ccc([C@H]2[C@H](O[Si](C(C)C)(C(C)C)C(C)C)CNC[C@@H]2O)cc1.Cc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)c1ccc([C@H]2[C@H](O[Si](C(C)C)(C(C)C)C(C)C)CN(S(=O)(=O)c3ccccc3C)C[C@@H]2O)cc1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20050203146A1,N#Cc1cccc(O)c1.O=[N+]([O-])c1cccnc1Cl>>N#Cc1cccc(Oc2ncccc2[N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150018343A1,Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1OC1CCN(C(=O)OC(C)(C)C)CC1C(F)(F)F)C3.Cl>>Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1OC1CCNCC1C(F)(F)F)C3.Cl,,C1COCCO1,,,,val
US20110212053A1,CC(C)(C#N)c1ccc(CC(=O)c2cc(Br)ccc2NC=O)cc1>>CC(C)(C#N)c1ccc(CC(=O)c2cc(Br)ccc2N)cc1,,CC(C)=O,,Cl,,val
US20100190778A1,CC1=NNS(=O)(=O)c2c(Cl)cccc21>>CC1NNS(=O)(=O)c2c(Cl)cccc21,O=[Pt]=O,,,,,val
US20040192767A1,Cc1occc1CO.Oc1ccc(-c2ccccc2)cc1>>Cc1occc1COc1ccc(-c2ccccc2)cc1,,CCOCC,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110257151A1,CC1(C)Cc2cc(Cl)ccc2NC1c1cccc(N)c1.COC(=O)C(C)(C)Br>>COC(=O)C(C)(C)Nc1cccc(C2Nc3ccc(Cl)cc3CC2(C)C)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04031226,NCCBr.O=C(Cl)c1ccc(F)cc1[N+](=O)[O-]>>O=C(NCCBr)c1ccc(F)cc1[N+](=O)[O-],,O,c1ccccc1,Br,[Na+].[OH-],val
US20110065681A1,CC(O)c1ccc(Cl)c(S(C)(=O)=O)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(N=[N+]=[N-])c1ccc(Cl)c(S(C)(=O)=O)c1,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,,val
US20070093521A1,CCOc1cc(CN2CCC(Nc3nc4cccc(N)c4o3)CC2)cc(OCC)c1F.COCC(=O)Cl>>CCOc1cc(CN2CCC(Nc3nc4cccc(NC(=O)COC)c4o3)CC2)cc(OCC)c1F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120252758A1,CC(c1cc(F)ccc1OC[C@H](C)N)C(F)(F)F.Cc1cn(-c2ccc3n(c2=O)CCOC3=O)cn1>>Cc1cn(-c2ccc(C(=O)N[C@@H](C)COc3ccc(F)cc3C(C)C(F)(F)F)n(CCO)c2=O)cn1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20150094436A1,CCCCC(CC)C[Si]1(CC(CC)CCCC)c2cc([Si](C)(C)C)sc2-c2sc([Si](C)(C)C)cc21>>CCCCC(CC)C[Si]1(CC(CC)CCCC)c2ccsc2-c2sccc21,,ClC(Cl)Cl,,O,O=C(O)C(F)(F)F,val
US04038414,CC(C)N.CCCCOC(=O)NC=Cc1ccc(OCC2CO2)cc1>>CCCCOC(=O)NC=Cc1ccc(OCC(O)CNC(C)C)cc1,,CC(C)O,,,,val
US20050176701A1,Br[Mg]C1CCCC1.O=C(CCC1=CCCCC1)Sc1ccccn1>>O=C(CCC1=CCCCC1)C1CCCC1,,C1CCOC1,CCOCC,,,val
US20070244086A1,CN1CCC(Oc2ccc(N)cc2-c2c(Cl)cnn2C)CC1.Cc1cc(C(=O)Cl)ccc1F>>Cc1cc(C(=O)Nc2ccc(OC3CCN(C)CC3)c(-c3c(Cl)cnn3C)c2)ccc1F,,ClCCl,,CCN(CC)CC,,val
US20060019985A1,C=CC(=O)O.COCN(Cc1ccccc1)C[Si](C)(C)C>>O=C(O)C1CCN(Cc2ccccc2)C1,O=C(O)C(F)(F)F,Cc1ccccc1,,,,val
US20140051672A1,CN(c1ccc(-c2cc3ccc(OCCCNC(=O)OC(C)(C)C)cc3cc2O)nn1)C1CC(C)(C)NC(C)(C)C1>>CN(c1ccc(-c2cc3ccc(OCCCN)cc3cc2O)nn1)C1CC(C)(C)NC(C)(C)C1,,CO,ClCCl,O=C(O)C(F)(F)F,,val
US20110224202A1,COC(C(=O)N(C)OC)c1ccc(-n2nccn2)cc1.COc1cc(-c2ccco2)cc(OC)c1Br>>COc1cc(-c2ccc(C(=O)C(OC)c3ccc(-n4nccn4)cc3)o2)cc(OC)c1Br,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US08802596B2,CCCCCCCCCC[N+](C)(C)CCCCCCCCCC.COc1ccc2cc([C@H](C)C(=O)[O-])ccc2c1>>CCCCCCCCCC[N+](C)(C)CCCCCCCCCC.COc1ccc2cc([C@H](C)C(=O)[O-])ccc2c1,,O,,[Cl-].[Na+],,val
US20070135385A1,CCOC(=O)c1cc2c(OC)ccnc2[nH]1>>COc1ccnc2[nH]c(CO)cc12,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20070232583A1,Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(=O)(=O)Cl)c3)n2)n1.c1cc(OC2CCNCC2)ccn1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(=O)(=O)N4CCC(Oc5ccncc5)CC4)c3)n2)n1,,C1CCOC1,CCOC(C)=O,,,val
US20120263670A1,CN1Cc2c(Cl)cc(Cl)cc2C(c2cccc([N+](=O)[O-])c2)C1>>CN1Cc2c(Cl)cc(Cl)cc2C(c2cccc(N)c2)C1,[Fe],O,,CCO,Cl,val
US05847186,COP(=O)(OC)[C@H](O)C=C(C)C>>COP(=O)(OC)[C@H](O)CC(C)C,[Pd],CO,,,,val
US20060189636A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O>>O[C@@H]1[C@@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)O[C@@H](n2cnc3c(Cl)ncnc32)[C@@H]1O,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20090082372A1,CNC(=O)c1ccc(C#Cc2ccc(OC(F)(F)F)c(C(=O)O)c2)cc1.NC(CO)Cc1n[nH]c2cccc(F)c12>>CNC(=O)c1ccc(C#Cc2ccc(OC(F)(F)F)c(C(=O)NC(CO)Cc3n[nH]c4cccc(F)c34)c2)cc1,CN(C)c1ccncc1,C1CCOC1,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040063754A1,CCOC(=O)C=CN(C)C.O=C(O)c1ccc(F)c(F)c1F>>CCOC(=O)C(=CN(C)C)C(=O)c1ccc(F)c(F)c1F,,C1CCOC1,CN(C)C=O,CCN(CC)CC,O=S(Cl)Cl,val
US05821241,CC(C)(C)OC(=O)N1CCC(CCN)CC1.COC(=O)c1cc(C(=O)OC)n(CCBr)n1>>COC(=O)c1cc2n(n1)CCN(CCC1CCN(C(=O)OC(C)(C)C)CC1)C2=O,,CC#N,,CCN(C(C)C)C(C)C,[I-].[K+],val
US20110212937A1,CCNC.Clc1nc(Cl)c2c(n1)C(c1ccccc1)CCC2>>CCN(C)c1nc(Cl)nc2c1CCCC2c1ccccc1,,CO,,,,val
US20110319380A1,COC1=NCCC(C)CC1.Nc1cc(C(=O)O)ccc1C(=O)O>>CC1CCc2nc3cc(C(=O)O)ccc3c(=O)n2CC1,,CN(C)C=O,O,,,val
US20150158879A1,CC(=O)OC(C)=O.CS(=O)(=O)c1nn(Cc2nc3cc(Cl)ccc3n2C2CCNC2)c2cnccc12>>CC(=O)N1CCC(n2c(Cn3nc(S(C)(=O)=O)c4ccncc43)nc3cc(Cl)ccc32)C1,CN(C)c1ccncc1,ClCCl,,O,,val
US04383949,COC(OC)OC.N#Cc1ccc(F)c(Br)c1>>COC(OC)c1ccc(F)c(Br)c1,[Ni],O,O=CO,CO,,val
US07022717B2,CS(=O)(=O)OCCC(CCOS(C)(=O)=O)Cc1ccc(CN(Cc2ccccn2)S(=O)(=O)c2ccccc2[N+](=O)[O-])cc1.O=[N+]([O-])C(CCOCCC(NS(=O)(=O)c1ccccc1)[N+](=O)[O-])NS(=O)(=O)c1ccccc1>>CS(=O)(=O)Oc1cc(Cc2ccc(CN(Cc3ccccn3)S(=O)(=O)c3ccccc3[N+](=O)[O-])cc2)cc(OS(C)(=O)=O)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04734415,COC1CCC(OC)O1.Nc1ccc(-c2ccc(=O)[nH]n2)cc1>>O=C1CCC(c2ccc(-n3cccc3)cc2)=NN1,,CC(=O)O,,,,val
US20090048269A1,CCCC[Sn](CCCC)(CCCC)c1cncnc1.Cc1ccc(Oc2ccnc(Cl)c2)c(I)n1>>Cc1ccc(Oc2ccnc(Cl)c2)c(-c2cncnc2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,CO,,val
US20100003250A1,CC1(C)OB(c2ccc(N)cc2)OC1(C)C.COC(Cn1ccc2c(N3CCOCC3)nc(Cl)nc21)OC>>COC(Cn1ccc2c(N3CCOCC3)nc(-c3ccc(N)cc3)nc21)OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20100234615A1,C[Si](C)(C)c1cn(C[C@H]2CN(c3ccc(I)c(F)c3)C(=O)O2)nn1>>O=C1O[C@@H](Cn2ccnn2)CN1c1ccc(I)c(F)c1,,CC(=O)O,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20150259317A1,CC(C)(C)OC(=O)CCC(=O)OCOC(=O)CCC(=O)OC(C)(C)C>>O=C(O)CCC(=O)OCOC(=O)CCC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030153505A1,CCOC(=O)C1CCCCN1C>>CN1CCCCC1C(=O)O,,CO,O,Cl,[Na+].[OH-],val
US20070179060A1,COC(=O)c1nc(I)cc(N)c1Cl.COCCOC.COc1c(Br)ccc(B(O)O)c1F>>COC(=O)c1nc(-c2ccc(Br)c(OC)c2F)cc(NC(C)=O)c1Cl,,O,,[Cs+].[F-],,val
US20140343023A1,CC(=O)O[C@H]1C[C@H]2[C@H]([C@@H]3CC[C@H]([C@H](C)CCC(=O)OC(C)C)[C@@]13C)[C@H](OC(C)=O)C[C@@H]1C[C@H](O)CC[C@]21C>>CC(=O)O[C@H]1C[C@H]2[C@H]([C@@H]3CC[C@H]([C@H](C)CCC(=O)OC(C)C)[C@@]13C)[C@H](OC(C)=O)C[C@@H]1CC(=O)CC[C@]21C,,CC(=O)O,,[Na+].[O-]Cl,,val
US06995179B2,C/C(N)=C/C(=O)OCCC#N.CCC(=O)CC(=O)OCC=Cc1ccccc1.O=Cc1cccc(Cl)c1>>CCC1=C(C(=O)OCC=Cc2ccccc2)C(c2cccc(Cl)c2)C(C(=O)OCCC#N)=C(C)N1,,CC(C)O,,,,val
US20050032871A1,Cc1[nH]c(C=O)c(CCC(=O)O)c1S(C)(=O)=O.O=C1Cc2cc(Cl)ccc2N1>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(Cl)cc32)c(CCC(=O)O)c1S(C)(=O)=O,,CCO,,C1CCNCC1,,val
US20090143353A1,CN[C@H]1CCNC1.CNc1nc2c(C#N)c(C)c(-c3ccccc3)c(F)c2o1.CS(C)=O>>CNc1nc2c(C#N)c(C)c(-c3ccccc3)c(N3CC[C@H](N(C)C)C3)c2o1,,CS(C)=O,ClCCl,CCN(CC)CC,,val
US20120157439A1,O=C(O)c1c(F)ccc(NS(=O)(=O)c2ccccc2)c1F.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Nc1c(F)ccc(NS(=O)(=O)c2ccccc2)c1F,,CN(C)C=O,O,CCN(CC)CC,,val
US20040087577A1,CC(C)CCn1c(=O)oc(=O)c2cccnc21.CCOC(=O)CC1=NS(=O)(=O)c2cc(OC)ccc2N1>>COc1ccc2c(c1)S(=O)(=O)N=C(c1c(O)c3cccnc3n(CCC(C)C)c1=O)N2,,C1CCOC1,,CC(=O)O,[H-].[Na+],val
US20100076029A1,CCOC(=O)C(C)(C)SC(C)=O.Cc1ccc(S(=O)(=O)OCCC(F)(F)F)cc1>>CCOC(=O)C(C)(C)SCCC(F)(F)F,,CCO,,C[O-].[Na+],,val
US06506751B1,C1COCCN1.O=C1CSC(c2cccc(F)c2)N1CCCCl>>O=C1CSC(c2cccc(F)c2)N1CCCN1CCOCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20150191461A1,C=Cc1nc(Cl)ncc1F.O.O=[Os](=O)(=O)=O>>OC(O)c1nc(Cl)ncc1F,O=[Os](=O)(=O)=O,,,C1CCOC1,,val
US20090105253A1,CC#N.CN1CCN(C)C1(F)F.O=C(NCC(F)(F)F)c1ccc(-n2cc(C(=O)NC3CC3)nn2)c(CCCCCO)c1>>CCNC(=O)c1ccc(-n2cc(C(=O)NC3CC3)nn2)c(CCCCCF)c1,,CC#N,,,,val
US20080139505A1,CCCc1c(OCc2ccc(C(N=[N+]=[N-])c3cccc(-c4nn[nH]n4)c3)cc2)ccc(C(C)=O)c1O>>CCCc1c(OCc2ccc(C(N)c3cccc(-c4nnn[nH]4)c3)cc2)ccc(C(C)=O)c1O,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110086454A1,CN(C)C=O.c1ccc([Si](c2ccccc2)(c2ccccc2)c2ccc3oc4ccc([Si](c5ccccc5)(c5ccccc5)c5ccccc5)cc4c3c2)cc1>>O=Cc1cc([Si](c2ccccc2)(c2ccccc2)c2ccccc2)cc2c1oc1ccc([Si](c3ccccc3)(c3ccccc3)c3ccccc3)cc12,,C1CCCCC1,C1CCOC1,Cl,,val
US04306097,C=CCC1CCC(O)CC1c1ccc(C(C)(C)CCCCCC)cc1O>>C=CC[C@@H]1CCC(=O)C[C@H]1c1ccc(C(C)(C)CCCCCC)cc1O,,CCOCC,ClCCl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US06180627B2,CN.COC(=O)c1cccc(C(=O)[O-])c1>>CNC(=O)c1cccc(C(=O)OC)c1,CN(C)C=O,C1CCOC1,ClCCl,O=C(Cl)C(=O)Cl,,val
US20080004327A1,CCOC(=O)c1cc2c(Br)csc2[nH]1.Cl[Cu]>>CCOC(=O)c1cc2c(Cl)csc2[nH]1,Cl[Cu],CN(C)C=O,,[Cl-].[NH4+],,val
US20140371274A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccccc1CNC(C(=O)O)c1ccc(C)cc1>>COc1ccccc1CN(C(=O)OC(C)(C)C)C(C(=O)O)c1ccc(C)cc1,,C1COCCO1,,[Na+].[OH-],,val
US20050004163A1,CCNC(=O)c1ccc(C(Br)=C2CC3CCC(C2)N3C(=O)OCC)cc1.OB(O)c1cccnc1>>CCNC(=O)c1ccc(C(=C2CC3CCC(C2)N3C(=O)OCC)c2cccnc2)cc1,,COCCOC,,O=C([O-])O.[Na+],,val
US20070213341A1,CCOC(=O)Cl.O=C1Nc2cc(Cl)ccc2/C1=C/c1ccccc1>>CCOC(=O)N1C(=O)/C(=C\c2ccccc2)c2ccc(Cl)cc21,,ClCCl,,CCN(CC)CC,,val
US20100004235A1,COc1ccc(Cn2c(-c3nn(Cc4ccccc4F)c4ncccc34)nn(CCCN3CCOCC3)c2=O)c(OC)c1>>O=c1[nH]c(-c2nn(Cc3ccccc3F)c3ncccc23)nn1CCCN1CCOCC1,,CC(=O)O,,O=S(=O)(O)O,O=C([O-])[O-].[Na+].[Na+],val
US20070093524A1,COc1cc(C=O)ccc1O.Nc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1>>COc1cc(CNc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)ccc1O,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150111933A1,CC(C)(C)OC(=O)NC[C@H]1S[C@@H](c2ccc(C#Cc3ccccc3)cc2)N(c2cccc(C(N)=O)c2)C1=O>>NC[C@H]1S[C@@H](c2ccc(C#Cc3ccccc3)cc2)N(c2cccc(C(N)=O)c2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150216175A1,CCI.COC(=O)c1cc2cc(C(=O)NC(c3cccc(C(F)(F)F)c3)C(F)(F)F)[nH]c2nc1C>>CCn1c(C(=O)NC(c2cccc(C(F)(F)F)c2)C(F)(F)F)cc2cc(C(=O)OC)c(C)nc21,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20030195176A1,CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)CC2=CC=C3[C@@H]4CC=C(CO)[C@@]4(C)CC[C@@H]3[C@]21C.CC[Si](CC)(CC)OC(C)(C)CCCCBr>>CC[Si](CC)(CC)OC(C)(C)CCCCOCC1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C,,C1CCOC1,,C1COCCOCCOCCOCCO1,[H-].[Na+],val
US04279913,CCOC(=O)c1cc(C)cnc1Br>>Cc1cnc(Br)c(C(=O)O)c1,,[Na+],[OH-],Cl,,val
US05811553,CC(=O)c1cccs1.O=C1Nc2ccccc2C1=O>>O=C(O)c1cc(-c2cccs2)nc2ccccc12,,O,,CCO,[K+].[OH-],val
US05039701,COc1c(C(C)=O)c(O)c(OC)c2occc12.COc1ccc(CCN(C)CCCCl)cc1OC>>COc1ccc(CCN(C)CCCOc2c(C(C)=O)c(OC)c3ccoc3c2OC)cc1OC,,CCC(C)=O,,,,val
US20020147203A1,N#Cc1cnc(Nc2cccc(CO)n2)s1.O=P(Cl)(Cl)Cl>>N#Cc1cnc(Nc2cccc(CCl)n2)s1,,ClCCl,O,CN(C)C=O,O=C([O-])O.[Na+],val
US20070049618A1,NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1ccc2c(c1)OCO2>>O=C1CCC(N2C(=O)c3cccc(CNC(=O)c4ccc5c(c4)OCO5)c3C2=O)C(=O)N1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20090298820A1,Brc1ccnc2[nH]ccc12.C=O.CNC>>CN(C)Cc1c[nH]c2nccc(Br)c12,,CCCCO,,Cl,,val
US20130116219A1,CC(C)CC=O.Cl.NCCc1c[nH]c2ccc(Cl)cc12>>CC(C)CC1NCCc2c1[nH]c1ccc(Cl)cc21.Cl,,O=S(=O)(O)O,,,,val
US20130210824A1,COC(=O)C(=O)C(C)(C)C(=O)OC.N=C(NN)c1nn(Cc2ccccc2F)c2c1CCC2>>COC(=O)C(C)(C)c1nnc(-c2nn(Cc3ccccc3F)c3c2CCC3)nc1O,,CCO,,,,val
US20020022631A1,CC(C)(C)OC(=O)NC1=NC(CI)CS1.c1nc[nH]n1>>CC(C)(C)OC(=O)NC1=NC(Cn2cncn2)CS1,,CS(C)=O,,[H-].[Na+],[Cl-].[NH4+],val
US05158949,O=C1CCC(=O)N1Br.OCCc1ccc(Cl)cc1>>Clc1ccc(CCBr)cc1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070185184A1,CC(=O)c1cn(-c2ccc(C(N)=O)cc2Cl)c2ccccc12>>CC(O)c1cn(-c2ccc(C(N)=O)cc2Cl)c2ccccc12,,CO,O,[BH4-].[Na+],,val
US20050208582A1,N#Cc1cc2cn[nH]c2s1.O=C1CCC(=O)N1Br>>N#Cc1cc2c(Br)n[nH]c2s1,,CCOC(C)=O,CN(C)C=O,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20120077814A1,CC(C)(C)Sc1ncnc2c(C3=CC(=O)C(CO)C3)csc12.COCCl>>COCOCC1CC(c2csc3c(SC(C)(C)C)ncnc23)=CC1=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080255136A1,CCOC(C)=O.O=[N+]([O-])C=Cc1cccc(OCc2ccccc2)c1>>CCOC(=O)CC(C[N+](=O)[O-])c1cccc(OCc2ccccc2)c1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20040138277A1,CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1cccc(F)c1.Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccc(-c4ccccc4)cc3)oc2C)cc1>>Cc1oc(-c2ccc(-c3ccccc3)cc2)nc1CCOc1ccc(CC(C)(Oc2cccc(F)c2)C(=O)O)cc1,,CCO,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20090048271A1,CC(=O)C(Cl)CC=O.Nc1ncccn1>>CC(=O)c1c(C)nc2ncccn12,,CCO,,,,val
US20150031689A1,CC(C)(C)OC(=O)N1CCC[C@H](Nc2ncnc3c2nc(-c2ccccc2Cl)n3-c2ccc(Cl)cc2)C1>>Clc1ccc(-n2c(-c3ccccc3Cl)nc3c(N[C@H]4CCCNC4)ncnc32)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030130518A1,COCCc1nc2c(N)nc3ccccc3c2n1CCOCCN.O=C=Nc1ccccc1>>COCCc1nc2c(N)nc3ccccc3c2n1CCOCCNC(=O)Nc1ccccc1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20080287432A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(Cl)ccnc21.CCOC(=O)CNC.CN(C)C=O>>CCOC(=O)c1cc2cnc3[nH]ccc3c2n1C,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US03959478,O=C(Cl)c1c(Cl)cccc1Cl.O=c1[nH]c(=O)n(-c2ccc(F)c(F)c2)o1>>O=C(c1c(Cl)cccc1Cl)n1c(=O)on(-c2ccc(F)c(F)c2)c1=O,,Cc1ccccc1,,CCN(CC)CC,,val
US20130345123A1,CC(=O)SCC[C@H](NC(=O)OCc1ccccc1)C(=O)O.NCCCCCO>>CC(=O)SCC[C@H](NC(=O)OCc1ccccc1)C(=O)NCCCCCO,,CCOC(C)=O,ClCCl,ClCCCl,On1nnc2ccccc21,val
US20160016908A1,CC(=O)N1c2ccc(C(=O)O)cc2[C@H](Nc2nccc(C)n2)[C@@H](C)[C@@H]1C1CC1.[NH4+]>>CC(=O)N1c2ccc(C(N)=O)cc2[C@H](Nc2nccc(C)n2)[C@@H](C)[C@@H]1C1CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090306042A1,CC(C)(C)OC(=O)N1CCCC[C@H]1C(=O)N[C@@H](Cc1ccc(-c2ccc3c(c2)sc(=O)n3CCO)cc1)C(N)=O.CC(C)(C)[Si](C)(C)Cl>>CC(C)(C)OC(=O)N1CCCC[C@H]1C(=O)N[C@@H](Cc1ccc(-c2ccc3c(c2)sc(=O)n3CCO[Si](C)(C)C(C)(C)C)cc1)C(N)=O,,CN(C)C=O,,O,c1c[nH]cn1,val
US20070037829A1,Cc1ccc(C(F)(F)CN[C@H]2CC[C@H](N)C2)cc1.Clc1ncnc2nn(C3CCCCO3)cc12>>Cc1ccc(C(F)(F)CN(c2ncnc3nn(C4CCCCO4)cc23)[C@H]2CC[C@H](N)C2)cc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20100144745A1,CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@H](N2C(=O)c3cc(Cl)c(Cl)cc3C2=O)C1>>OC1CCC(N2[C@@H](O)c3cc(Cl)c(Cl)cc3[C@H]2O)C1,,CO,,Cl,,val
US20110144056A1,CCBr.OCc1ccc2nc(-c3ccn[nH]3)ccc2c1>>CCn1ccc(-c2ccc3cc(CO)ccc3n2)n1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20070072876A1,CS/C(NC(=O)c1ccc(SC)cc1)=C(\C#N)C(=O)Nc1ccc(C)cc1>>CSc1ccc(-c2nc(O)c(C(=O)Nc3ccc(C)cc3)c(SC)n2)cc1,,ClCCl,,CCO,Cl,val
US20140131628A1,CCCCCCCCCCCCCc1csc2c(Br)c(-c3sc4c(CCCCCCCCCCCCC)csc4c3Br)sc12.CCCCCCCC[Si](Cl)(Cl)CCCCCCC.[Li]CCCC>>CCCCCCCCCCCCCc1csc2c3c(sc12)-c1sc2c(CCCCCCCCCCCCC)csc2c1[Si]3(CCCCCCCC)CCCCCCCC,,C1CCOC1,,,,val
US05703246,Cc1ccc(S(=O)(=O)NCc2ccccc2)cc1.O=N[O-]>>Cc1ccc(S(=O)(=O)N(Cc2ccccc2)N=O)cc1,,CC(=O)OC(C)=O,,CC(=O)O,,val
US20090253758A1,C[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](Nc1ccc(C#N)c(C(F)(F)F)c1)c1nnc(-c2ccc(C#N)cc2)o1>>C[C@@H](O)[C@@H](Nc1ccc(C#N)c(C(F)(F)F)c1)c1nnc(-c2ccc(C#N)cc2)o1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150197511A1,Cc1cc([N+](=O)[O-])cnc1Oc1ccnc(N(C(=O)OC(C)(C)C)C(=O)C2CC2)c1>>Cc1cc([N+](=O)[O-])cnc1Oc1ccnc(NC(=O)C2CC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100029718A1,Cc1nc(N2CCCC(=Cc3cccnc3)C2=O)sc1C(=O)NCc1ccccc1>>Cc1nc(N2CCCC(Cc3cccnc3)C2=O)sc1C(=O)NCc1ccccc1,[Pd],CCOC(C)=O,,,,val
US20150175562A1,O=[N+]([O-])O.Oc1nccc2ccccc12>>O=[N+]([O-])c1cnc(O)c2ccccc12,,CC(=O)O,O,,,val
US20030060473A1,CCOC(=O)[C@H]1CN(C(=O)OCc2ccccc2)CCN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)C[C@@H]1C(=O)O,,C1COCCO1,,[Na+].[OH-],,val
US20100331335A1,CI.O=C(Cn1c(=O)ccn2nccc12)Nc1scc(Cl)c1-c1nc[nH]n1>>Cn1cnc(-c2c(Cl)csc2NC(=O)Cn2c(=O)ccn3nccc23)n1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04512990,O=C(CCCCO)N1CCCc2ccccc21>>OCCCCCN1CCCc2ccccc21,,CCOCC,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20090048306A1,Fc1ccc(OCCCl)c(Br)c1>>C=COc1ccc(F)cc1Br,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccco2)c1C#N.NCc1ccc(N)cc1>>N#Cc1c(NCc2ccc(N)cc2)nc(N)nc1-c1ccco1,,COCCOC,,,,val
US20070049581A1,CCOC(=O)CCCN1CCC(N2CCNCC2)CC1.Nc1c(Cl)cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc1C(F)(F)F>>CCOC(=O)CCCN1CCC(N2CCN(C(=O)[C@@H](Cc3cc(Cl)c(N)c(C(F)(F)F)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20130109682A1,CC1(C)OO1.CC[Si](CC)(CC)OC1=CC2(CC2)O[C@@H](c2ccncc2[N+](=O)[O-])C1>>O=C1C[C@H](c2ccncc2[N+](=O)[O-])OC2(CC2)[C@H]1O,,ClCCl,,CC(C)=O,,val
US04098888,CCOC(=O)C(=NOC)c1csc(N)n1.O=C(Cl)CCl>>CCOC(=O)C(=NOC)c1csc(NC(=O)CCl)n1,,CC(=O)N(C)C,,,,val
US20020019569A1,CC(C)(C)ON.O=Cc1ccc(CCCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)cc1>>CC(C)(C)ON=Cc1ccc(CCCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)cc1,,c1ccncc1,,Cl,Cl,val
US20130158009A1,CCc1cnc(N2CCC(N3CCC[C@H](NC(=O)OCc4ccccc4)C3=O)CC2)nc1.CI>>CCc1cnc(N2CCC(N3CCC[C@H](N(C)C(=O)OCc4ccccc4)C3=O)CC2)nc1,,CN(C)C=O,,[H-].[Na+],,val
US05405997,CCNCCCC(O)c1ccc(NS(C)(=O)=O)cc1.FC(F)CCCCCBr>>CCN(CCCCCC(F)F)CCCC(O)c1ccc(NS(C)(=O)=O)cc1,,CC#N,,O=C([O-])O.[Na+],,val
US20060183921A1,CCOC(=O)c1c(-c2cccc(OC)c2)csc1N.O=C1OC(=O)c2ccccc21>>CCOC(=O)c1c(-c2cccc(OC)c2)csc1N1C(=O)c2ccccc2C1=O,,CC(=O)O,,,,val
US20090209522A1,COc1nc(NCCN(C(=O)OC(C)(C)C)C(C)C)nc(OC)c1NC(=O)c1csc(Oc2cc(OC(C)C)ccc2C)n1>>COc1nc(NCCNC(C)C)nc(OC)c1NC(=O)c1csc(Oc2cc(OC(C)C)ccc2C)n1,,CCOC(C)=O,,,,val
US08138197B2,CCOc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(-c4cncc(C(=O)OC)c4)ccc2O3)cc(OC)c1-c1cnn(C)c1>>CCOc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(-c4cncc(C(=O)O)c4)ccc2O3)cc(OC)c1-c1cnn(C)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20020183361A1,CCC(CC)[C@H](NS(=O)(=O)c1ccc(Cl)s1)C(=O)O.CO>>CCC(CC)[C@H](NS(=O)(=O)c1ccc(Cl)s1)C(=O)OC,,C1CCOC1,CO,C[Si](C)(C)C=[N+]=[N-],,val
US05112834,Cc1nc2c(O[C@@H]3c4ccccc4C[C@H]3O)cccn2c1C=O>>Cc1nc2c(O[C@@H]3c4ccccc4C[C@H]3O)cccn2c1CO,,CO,,[BH4-].[Na+],,val
US20090298823A1,CC(=O)c1cn(S(=O)(=O)c2ccc(C)cc2)c2nc(Cl)nc(NC3CC3)c12.Nc1ccc2cn[nH]c2c1>>CC(=O)c1c[nH]c2nc(Nc3ccc4cn[nH]c4c3)nc(NC3CC3)c12,,CCCCO,,C[Si](C)(C)Cl,,val
US04259338,CCOC(=O)c1ccc(OC2CCCCC2=O)cc1>>CCOC(=O)c1ccc2oc3c(c2c1)CCCC3,,O=S(=O)(O)O,,O=C([O-])[O-].[Na+].[Na+],,val
US04412934,CC(=O)Oc1ccccc1S(=O)(=O)[O-].O=BO[O-].O=O.[Na+].[Na+]>>CC(=O)Oc1ccccc1S(=O)(=O)[O-].O=BO[O-].OO.[Na+].[Na+],,O,,,,val
US20090023720A1,CC(C)(F)CNc1c([N+](=O)[O-])c(Cl)nc2ccccc12>>CC(C)(F)CNc1c(N)c(Cl)nc2ccccc12,[Pt],CC#N,,,,val
US20100234344A1,COc1ccc(F)c2c(Cl)cc(C)nc12>>Cc1cc(Cl)c2c(F)ccc(O)c2n1,,Cc1ccccc1,ClCCl,BrB(Br)Br,,val
US20080085890A1,COC(OC)OC.O=C1Cc2cc(-n3cccc3)ccc2C(=O)N1>>CO/C=C1/C(=O)NC(=O)c2ccc(-n3cccc3)cc21,,CC(=O)OC(C)=O,,CN(C)C=O,,val
US05753664,Cn1c(S)nc2ccsc2c1=O.O=C(c1ccc(CBr)cc1)c1ccc(CBr)cc1.c1ccc(N2CCNCC2)cc1>>Cn1c(SCc2ccc(C(=O)c3ccc(CN4CCN(c5ccccc5)CC4)cc3)cc2)nc2ccsc2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120277224A1,CN(C)C=C(C#N)c1ccccn1.NN>>Nc1[nH]ncc1-c1ccccn1,,CCO,O,Br,,val
US20100120741A1,CCOC(CNc1nc2cc(Cl)c(F)cc2nc1N1CCN(C(=O)OC(C)(C)C)CC1)OCC>>CC(C)(C)OC(=O)N1CCN(c2nc3cc(F)c(Cl)cc3n3ccnc23)CC1,,CC(C)O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20130217762A1,Cc1c(F)ccc(C#N)c1Cl.N[C@@H]1CCCC[C@@H]1O>>Cc1c(N[C@@H]2CCCC[C@@H]2O)ccc(C#N)c1Cl,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US04908367,Cn1ccc2c(N)cccc21.O=C(O)c1ccccc1O>>Cn1ccc2c(NC(=O)c3ccccc3O)cccc21,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130184257A1,CC(C)C(=O)OC(=O)C(C)C.CS(=O)(=O)c1cc(F)c(N[C@H]2CCCN(C3CCN(C(=N)NO)CC3)C2=O)c(F)c1>>CC(C)c1nc(N2CCC(N3CCC[C@H](Nc4c(F)cc(S(C)(=O)=O)cc4F)C3=O)CC2)no1,,C1COCCO1,,,,val
US20100130471A1,Nc1ccccc1.O=C(O)c1c(Cl)cccc1Br>>O=C(Nc1ccccc1)c1c(Cl)cccc1Br,,CN(C)C=O,ClCCl,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20090186868A1,COc1ccc(N=CC(F)F)cc1.C[C@@H]1O[C@](C)(C(C)(C)C)OC1=O>>COc1ccc(N2C(=O)[C@](C)(O)[C@@H]2C(F)F)cc1,,C1CCOC1,CN(C)P(=O)(N(C)C)N(C)C,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US04954507,CCOC(=O)[C@H]1CC(O)CN1S(=O)(=O)c1ccc(C)cc1>>Cc1ccc(S(=O)(=O)N2CC(O)C[C@@H]2CO)cc1,,C1CCOC1,,Cl,[BH4-].[Li+],val
US20140206663A1,C[C@H](c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12)C1(C)CN(C(=O)OC(C)(C)C)C1>>C[C@H](c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12)C1(C)CNC1,,Cl,,,,val
US20100331306A1,CCc1nc2ccc(F)cc2c(C(=O)O)c1-c1ccccn1.CO>>CCc1nc2ccc(F)cc2c(C(=O)OC)c1-c1ccccn1,,CO,,C[Si](C)(C)C=[N+]=[N-],,val
US20090029947A1,C=CCC(O)c1ccc(CCCCCCCC)cc1.CC(C)(C)[Si](C)(C)Cl>>C=CCC(O[Si](C)(C)C(C)(C)C)c1ccc(CCCCCCCC)cc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20110136763A1,CCOC(=O)C[C@@H]1OB(O)c2cc(O)cc(C)c21>>Cc1cc(O)cc2c1C(CC(=O)O)OB2O,,C1CCOC1,O,[Li+].[OH-],,val
US20150141433A1,COC(=O)c1ccc(CNS(=O)(=O)c2ccc(F)c(Cl)c2)nn1>>O=C(O)c1ccc(CNS(=O)(=O)c2ccc(F)c(Cl)c2)nn1,,CO,,[K+].[OH-],,val
US06300352B1,CC(C)(C)[Si](C)(C)Cl.CC(C)[C@H](Oc1ccc(Br)cc1)[C@H](O)CCc1cccnc1>>CC(C)C(Oc1ccc(Br)cc1)C(CCc1cccnc1)O[Si](C)(C)C(C)(C)C,,CN(C)C=O,,CCOCC,O,val
US05028614,C=CCC(O)C1C(OCc2ccccc2)C(OCc2ccccc2)C(OCc2ccccc2)C(COCc2ccccc2)N1Cc1ccccc1.O=C(Cl)c1ccccc1>>C=CCC(OC(=O)c1ccccc1)C1C(OCc2ccccc2)C(OCc2ccccc2)C(OCc2ccccc2)C(COCc2ccccc2)N1Cc1ccccc1,,ClCCl,O,CCN(CC)CC,O=C([O-])O.[Na+],val
US20110076292A1,Fc1ccc(-n2ncnc2-c2cn3c(n2)-c2cnc(Cl)cc2OCC3)c(F)c1.NC(=O)[C@@H]1CCCN1>>NC(=O)[C@@H]1CCCN1c1cc2c(cn1)-c1nc(-c3ncnn3-c3ccc(F)cc3F)cn1CCO2,,CN1CCCC1=O,ClCCl,CCN(CC)CC,[Cl-].[NH4+],val
US20120010182A1,Cn1nccc1-c1cc(-c2ccccc2)ccc1O.N#Cc1cc(S(=O)(=O)Nc2ccc(F)cn2)ccc1F>>Cn1nccc1-c1cc(-c2ccccc2)ccc1Oc1ccc(S(=O)(=O)Nc2ccc(F)cn2)cc1C#N,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20140155398A1,COC(=O)c1c(Cl)cc(CO)cc1Cl>>O=C(O)c1c(Cl)cc(CO)cc1Cl,,c1ccncc1,,[I-].[Li+],,val
US04522948,CCCCC(CC1CCCCC1)(C(=O)OCC)C(=O)OCC>>CCCCC(CC1CCCCC1)(C(=O)O)C(=O)O,,CO,O,[K+].[OH-],,val
US20040024132A1,S=C(Cl)Oc1ccccc1.SCc1ccccc1>>S=C(Oc1ccccc1)SCc1ccccc1,,O,,CCOCC,[Na+].[OH-],val
US20120077814A1,COCOC[C@@H]1CC(c2csc3c(S(=O)(=O)C(C)(C)C)ncnc23)=C[C@@H]1O>>COCOC[C@@H]1CC(c2csc3c(S(=O)(=O)C(C)(C)C)ncnc23)C[C@@H]1O,,ClCCl,,,,val
US04859686,CC(=O)NNC(=O)c1ccccc1>>Cc1nnc(-c2ccccc2)o1,,CC(=O)OC(C)=O,,[O-][Cl+3]([O-])([O-])O,,val
US20130281428A1,CCOC(=O)c1c[nH]cc(-c2ccccc2)c1=O.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CCOC(=O)c1cn(CC(F)(F)F)cc(-c2ccccc2)c1=O,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20160272595A1,CCSc1ccc(Cl)cc1CN.Nc1ccc(C(F)(F)F)cc1C(=O)O>>CCSc1ccc(Cl)cc1CNC(=O)c1cc(C(F)(F)F)ccc1N,,CN(C)C=O,,,,val
US20110183947A1,C[Si](C)(C)C=[N+]=[N-].O=C(CCCCCCc1ccccc1)c1nnc(-c2ccccn2)[nH]1>>Cn1c(C(=O)CCCCCCc2ccccc2)nnc1-c1ccccn1,,CO,,ClCCl,,val
US07282586B1,OO.c1cnc2c(c1)ccc1cccnc12>>[O-][n+]1cccc2ccc3cccnc3c21,,CC(=O)O,,,,val
US20070060480A1,C(=NCc1ccccc1)c1ccccc1.[C-]#[N+]CC(=O)OCC>>CCOC(=O)C1N=CN(Cc2ccccc2)C1c1ccccc1,,CCO,,,,val
US20040186143A1,CC#C[C@H](O)[C@H](CN(Cc1ccc(C)cc1C)C(=O)OCc1ccccc1)N1CC[C@H](NC(=O)OC(C)(C)C)C1=O.O=C=Nc1cccc(C(F)(F)F)c1>>CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)N1CC[C@H](NC(=O)Nc2cccc(C(F)(F)F)c2)C1=O,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20100063054A1,CCOC(=O)C(F)(F)c1ccc(Cl)nn1.NNc1ccc(Br)cn1>>O=C(NNc1ccc(Br)cn1)C(F)(F)c1ccc(Cl)nn1,,CO,,CCN(C(C)C)C(C)C,,val
US04486428,CC(CCCc1ccccc1)c1ccc2c(c1)OC(C)(O)CC2C(C)CC#N.COc1cc(CNCCCNCCCCNCCCN)ccc1O>>CC1CC(C(C)CCN)c2c(O)cc(C(C)CCCc3ccccc3)cc2O1,,C1CCOC1,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20050032873A1,COC(=O)c1cccc2c1CC(N(CCCc1c[nH]c3c(F)cc(F)cc13)C1CCC1)CO2>>O=C(O)c1cccc2c1CC(N(CCCc1c[nH]c3c(F)cc(F)cc13)C1CCC1)CO2,,C1CCOC1,CCOC(C)=O,[Na+].[OH-],,val
US20010027196A1,CSc1cc(-c2ccco2)nc(N)n1.O=S(=O)(c1ccccc1)N1OC1c1ccccc1>>CS(=O)c1cc(-c2ccco2)nc(N)n1,,ClCCl,,,,val
US20080051418A1,CC(C)Oc1nn(CCO)cc1C(=O)NCc1ccc(Cl)cc1Cl.COC(=O)Cc1cccc(OC)c1O>>COc1cccc(CC(=O)O)c1OCCn1cc(C(=O)NCc2ccc(Cl)cc2Cl)c(OC(C)C)n1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20060217387A1,CC1(C)OC(=O)C=C(CC(O)(O)C(F)(F)F)O1>>O=c1cc(O)cc(C(F)(F)F)o1,,Cc1ccccc1,,,,val
US20060247276A1,BrCOc1ccccc1.O=CN1CCCCC1>>COc1ccccc1C=O,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20120122817A1,CCOC(=O)C(=CN(C)C)C(=O)c1cc(Br)ncc1F.CN1CC(N)C1>>CCOC(=O)c1cn(C2CN(C)C2)c2cnc(Br)cc2c1=O,,C1CCOC1,,Cl,O=C([O-])[O-].[K+].[K+],val
US20040102464A1,Cc1ccc(-c2c(NS(=O)(=O)CCc3ccccc3)ncnc2OCCO)cc1.Clc1ncccn1>>Cc1ccc(-c2c(NS(=O)(=O)CCc3ccccc3)ncnc2OCCOc2ncccn2)cc1,,C1CCOC1,,[H-].[Na+],,val
US20080318996A1,CC(C)(C)OC(=O)N[C@@H]1Cc2ccc(Br)cc2C1.CCCBr>>CCCN(C(=O)OC(C)(C)C)[C@@H]1Cc2ccc(Br)cc2C1,,CN(C)C=O,,[H-].[Na+],,val
US20130059853A1,CC1(CBr)COC1.COc1ccc(-c2cccc3c2CCC3=O)c(OC)c1O>>COc1ccc(-c2cccc3c2CCC3=O)c(OC)c1OCC1(C)COC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120088748A1,CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Cl)c(Cl)c2)[C@H](CN)C1.O=C1OC(=O)c2cc(F)c(F)cc21>>CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Cl)c(Cl)c2)[C@H](CNC(=O)c2cc(F)c(F)cc2C(=O)O)C1,,CCOC(C)=O,CN(C)C=O,,,val
US20120202776A1,COc1cc(P(C)(C)=O)ccc1N.Clc1nnc(Cl)c(Nc2ccccc2)n1>>COc1cc(P(C)(C)=O)ccc1Nc1nnc(Cl)c(Nc2ccccc2)n1,,CC(C)O,ClCCl,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US05266568,CC(C)(OC1CCCCO1)c1ccccc1CC[C@@H](O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1>>CC(C)(OC1CCCCO1)c1ccccc1CC[C@H](O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080287458A1,CN1CCNCC1.O=Cc1ccc(S(=O)(=O)Cl)cc1>>CN1CCN(S(=O)(=O)c2ccc(C=O)cc2)CC1,,ClCCl,,O=C([O-])O.[Na+],,val
US05516774,Cc1ccccc1C(=O)Nc1ccc(C(=O)Cl)cc1.Clc1ccc2c(c1)Cn1ccnc1CN2>>Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3nccn3Cc3cc(Cl)ccc32)cc1,,ClCCl,,CCN(CC)CC,,val
US06491989B1,CCCCCCCCBr.CCCCCCCCOc1ccc(C2CCc3c(cc(F)c(F)c3O)C2(F)F)cc1>>CCCCCCCCOc1ccc(C2CCc3c(cc(F)c(F)c3OCCCCCCCC)C2(F)F)cc1,,CCOCC,,,,val
US20060111347A1,CC(C)(C)OC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21>>N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21,,CO,,CCOCC,Cl,val
US20010018446A1,CCc1cc(O)ccc1Cl.O=[N+]([O-])c1cccc([N+](=O)[O-])c1>>CCc1cc(Oc2cccc([N+](=O)[O-])c2)ccc1Cl,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050267095A1,CC(=O)OC(C)=O.c1cc(C2(CN3CCNCC3)CCOCC2)ccc1OCCCN1CCCC1>>CC(=O)N1CCN(CC2(c3ccc(OCCCN4CCCC4)cc3)CCOCC2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04472305,CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(N)=O>>CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1)C(N)=O,,CC(=O)O,,Cl,,val
US20140094474A1,Fc1cc(-c2ccnn2C2CCCCO2)c(F)c(Cl)c1I.N#C[Cu]>>N#Cc1c(F)cc(-c2ccnn2C2CCCCO2)c(F)c1Cl,,CN1CCCC1=O,,,,val
US20100137317A1,N#C[Cu].Nc1noc(C2CN3CCC2C3)n1>>N#Cc1ccc2nonc2c1,,O,,CN(C)C=O,,val
US20090156610A1,CS(=O)(=O)OC1CCC2(CC1)OCCO2.O=Cc1cc(Cl)ccc1O>>O=Cc1cc(Cl)ccc1OC1CCC2(CC1)OCCO2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150250169A1,CCCNC1=C(OCc2ccccc2)C(=O)O[C@@H]1[C@@H]1COC(C)(C)O1>>CCCNC1=C(OCc2ccccc2)C(=O)O[C@@H]1[C@@H](O)CO,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20110111046A1,CO.O=C(O)c1ccc([N+](=O)[O-])cn1>>COC(=O)c1ccc([N+](=O)[O-])cn1,,CO,,O=S(=O)(O)O,O=C([O-])[O-].[Na+].[Na+],val
US20120053173A1,CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(OCc4ccccc4)cc3c2C)C2CCCCC2)cc1>>CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(O)cc3c2C)C2CCCCC2)cc1,O=[Pt],CCO,,,,val
US05304560,Cl[Sn]Cl.O=c1[nH]c(=O)n(CCCCN2CC=C(c3ccccc3)CC2)c2cc([N+](=O)[O-])ccc12>>Cl.Nc1ccc2c(=O)[nH]c(=O)n(CCCCN3CC=C(c4ccccc4)CC3)c2c1,,CCO,,,,val
US05554607,CCNCC(=O)O.CCc1cccc(C(C)C)c1N=C=S>>CCc1cccc(C(C)C)c1N1C(=O)CN(CC)C1=S,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20100249163A1,CC(=O)N(C)Cc1ccc(Cl)c(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(O)c2ccc(F)c(F)c2)C2CC2)c1>>CC(=O)N(C)Cc1ccc(Cl)c(CN(C(=O)C2CNCCC2(O)c2ccc(F)c(F)c2)C2CC2)c1,,ClCCl,,Cl,,val
US06479471B1,C=C(CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1.CCCC[PH](=O)O>>CCCCP(=O)(O)CC(CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1,,ClCCl,,CCN(CC)CC,C[Si](C)(C)Cl,val
US20070197622A1,CCc1cccc(Cl)c1C(O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CCc1cccc(Cl)c1C(O)c1c[nH]cn1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US05912247,O=C(OCc1ccccc1)N1CCN(c2nc(OCC(O)C(O)CO)c3ccccc3n2)CC1>>OCC(O)C(O)COc1nc(N2CCNCC2)nc2ccccc12,[Pd],CO,,C1COCCO1,,val
US05154918,NCCCS.O=C1CCCC(=O)O1>>O=C(O)CCCC(=O)NCCCS,,CO,,,,val
US20130116430A1,C1COCCN1.O=[N+]([O-])c1cnc(Cl)c(-n2nccn2)c1>>O=[N+]([O-])c1cnc(N2CCOCC2)c(-n2nccn2)c1,,O,,C1COCCO1,,val
US04710507,COc1ccc2cc(-c3cccnc3)ccc2n1>>O=c1ccc2cc(-c3cccnc3)ccc2[nH]1,,Br,,[Na+].[OH-],,val
US20080194650A1,COC(=O)c1cccc(Br)c1OC>>COc1c(Br)cccc1CO,,CCOCC,,CO,[BH4-].[Li+],val
US05536701,COc1cnnc(Cl)c1.Cn1nc([Si](C)(C)C(C)(C)C)cc1O>>COc1cnnc(Oc2cc([Si](C)(C)C(C)(C)C)nn2C)c1,,Cc1ccccc1C,,Cc1cccc(C)n1,,val
US20100234357A1,C=C(C)CBr.Cc1c(O)cccc1Cl>>C=C(C)COc1cccc(Cl)c1C,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110009454A1,CCCI.Nc1ncccc1C(=O)NCc1cccc(O)c1F>>CCCOc1cccc(CNC(=O)c2cccnc2N)c1F,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US05962450,CCCN(CCC)Cc1csc(-c2ncn3c2CN(C)C(=O)c2c-3ccc(F)c2Cl)n1.Cl>>CCCN(CCC)Cc1csc(-c2ncn3c2CN(C)C(=O)c2c-3ccc(F)c2Cl)n1.Cl,,CCO,,,,val
US05145870,O=C(CCCl)c1ccccc1>>OC(CCCl)c1ccccc1,,CCO,,[BH4-].[Na+],,val
US05495023,CC(=O)OC(C)=O.CC/C=C(C)/C=C/CO>>CC/C=C(C)/C=C/COC(C)=O,,c1ccncc1,,,,val
US04753953,CNCC1CNCC1C.O=C(O)c1cn(C2CC2)c2c(Cl)c(F)c(F)cc2c1=O>>CNCC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)CC1C,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20030092677A1,CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccc(F)cc2)cc1NC(=O)CC(=O)c1cccc(C#N)c1>>N#Cc1cccc(C2=Nc3ccc(C#Cc4ccc(F)cc4)cc3NC(=O)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060135484A1,CC(=O)O.CCC(CC)(c1ccc(OCC(O[Si](C)(C)C(C)(C)C)C(C)(C)C)c(C)c1)c1cc(C)c(S(N)(=O)=O)s1>>CCC(CC)(c1ccc(OCC(O[Si](C)(C)C(C)(C)C)C(C)(C)C)c(C)c1)c1cc(C)c(S(=O)(=O)NC(C)=O)s1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US04095021,CC(C)(C)OC(=O)CON.O=C(O)C(=O)c1ccsc1>>CC(C)(C)OC(=O)CON=C(C(=O)O)c1ccsc1,,ClC(Cl)(Cl)Cl,,,,val
US20070148093A1,COC(=O)C(N)Cc1ccc2[nH]cc(C#N)c2c1.O=C(c1ncc[nH]1)c1ncc[nH]1.O=C1Nc2ccccc2CN1C1CCNCC1>>COC(=O)C(Cc1ccc2[nH]cc(C#N)c2c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1,,C1CCOC1,,,,val
US20150252038A1,CC(C)(C)OC(=O)c1cc(C2CC2)c(O[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)cc1F.CO>>COC(=O)c1cc(C2CC2)c(O[C@@H]2CCCNC2)cc1F,,CO,,O=S(=O)(O)O,,val
US04518597,COc1ccc([N+](=O)[O-])c(C=O)c1>>COc1ccc(N)c(CO)c1,[Ni],CO,,[H][H],,val
US20120208806A1,CC(C)(C)c1ccc(B(O)O)cc1.CC(C)NCCCn1c(Sc2cc3c(cc2I)OCO3)nc2c(N)ncnc21>>CC(C)NCCCn1c(Sc2cc3c(cc2-c2ccc(C(C)(C)C)cc2)OCO3)nc2c(N)ncnc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,CN(C)C=O,O=C([O-])O.[Na+],val
US20070213337A1,CC1CN(Cc2ccccc2)CC2Cc3ccccc3C(=O)N12>>C[C@@H]1CN(C)C[C@H]2Cc3ccccc3C(=O)N21,[Pd],CO,,[H][H],,val
US20030055055A1,CCOC(=O)CBr.O=[N+]([O-])c1cccc(N2CCNCC2)c1>>CCOC(=O)CN1CCN(c2cccc([N+](=O)[O-])c2)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US20040092502A1,CC(C)(C)OC(=O)N1C[C@H]2C(=O)N3CCCc4cccc(c43)[C@@H]2C1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1C[C@H]2CN3CCCc4cc(Br)cc(c43)[C@@H]2C1,,CCOC(C)=O,CN(C)C=O,,,val
US20110172221A1,CC1=C(C#N)C(c2ccc3[nH]nc(Br)c3c2)C(C#N)=C2COCCN12.OB(O)c1ccc(F)nc1>>CC1=C(C#N)C(c2ccc3[nH]nc(-c4ccc(F)nc4)c3c2)C(C#N)=C2COCCN12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])O.[Na+],,val
US20130196964A1,Cc1cc(-c2nc(-c3ccc(C4CCOCC4)c(C)c3)no2)n[nH]1.ClCc1ccnc(Cl)c1>>Cc1cc(-c2noc(-c3cc(C)n(Cc4ccnc(Cl)c4)n3)n2)ccc1C1CCOCC1,,C1CCOC1,CO,O,CC(C)(C)[O-].[K+],val
US20110076292A1,COCc1nc(-c2cn3c(n2)-c2cnc(Cl)cc2OCC3)n(CC(F)(F)F)n1>>OCc1nc(-c2cn3c(n2)-c2cnc(Cl)cc2OCC3)n(CC(F)(F)F)n1,,Br,,[K+].[OH-],,val
US20080262042A1,CN(Cc1cc(-c2cccnc2C#N)n(S(=O)(=O)c2ccccc2)c1)C(=O)OC(C)(C)C.Cl>>CNCc1cc(-c2cccnc2C#N)n(S(=O)(=O)c2ccccc2)c1.Cl,,CCOC(C)=O,CO,,,val
US20080009486A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1Nc2cc(Cl)ccc2/C1=C/c1cc(Cl)ccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)N1C(=O)C(=Cc2cc(Cl)ccc2[N+](=O)[O-])c2ccccc21,CN(C)c1ccncc1,ClCCl,,,,val
US20140194415A1,CC(C)(C)OC(=O)N1CCC2(CC1)CN(C1(CO[Si](C)(C)C(C)(C)C)CC1)C(=O)CO2>>O=C1COC2(CCNCC2)CN1C1(CO)CC1,,C1COCCO1,,Cl,,val
US20150361069A1,CC(C)(C)Sc1cc2c(O)ncnc2cc1F.O=S([O-])OO>>CC(C)(C)S(=O)(=O)c1cc2c(O)ncnc2cc1F,,CCOC(C)=O,CO,O,,val
US20120302567A1,O.O=Cc1csc2cnc(Cl)nc12>>O=C(O)c1csc2c(Cl)ncnc12,,CS(C)=O,,[Na+].[O-]Cl,,val
US20080146606A1,CI.Cc1cc2c(-c3ccc(S(=O)(=O)NC4CCS(=O)(=O)CC4)cc3)ccnc2n1S(=O)(=O)c1ccccc1>>Cc1cc2c(-c3ccc(S(=O)(=O)N(C)C4CCS(=O)(=O)CC4)cc3)ccnc2n1S(=O)(=O)c1ccccc1,,ClCCl,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04782079,COCOc1ccc(-c2ccc(C=C(Br)Br)s2)cc1>>Oc1ccc(-c2ccc(C=C(Br)Br)s2)cc1,Cl,C1CCOC1,CCOCC,CCO,,val
US20050197373A1,CCc1cc(NC(=O)Oc2ccccc2)cc(-c2nnnn2C)c1.N[C@@H]1CC[C@@H]2CN(C(c3ccccc3)(c3ccccc3)c3ccccc3)C[C@H]12>>CCc1cc(NC(=O)NC2CCC3CN(C(c4ccccc4)(c4ccccc4)c4ccccc4)CC32)cc(-c2nnnn2C)c1,,CN(C)C=O,,CC#N,CCN(CC)CC,val
US05420280,O=CC1(Nc2ccccc2)CCN(Cc2ccccc2)CC1>>OCC1(Nc2ccccc2)CCN(Cc2ccccc2)CC1,,CO,O,[BH4-].[Na+],,val
US20100216746A1,CC(C)(C)OC(=O)N1CCCC[C@H]1C(=O)Nc1ccc2[nH]c(C(=O)NCc3ccc(Cl)c(Oc4cc(Cl)cc(C#N)c4)c3F)cc2c1.O=C(O)C(F)(F)F>>N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CNC(=O)c3cc4cc(NC(=O)[C@@H]5CCCCN5)ccc4[nH]3)c2F)c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20070167622A1,C1CC[C@H]2CNCC[C@@H]2C1.COc1cccc(F)c1-c1nc(C(=O)O)cs1>>COc1cccc(F)c1-c1nc(C(=O)N2CCCCC2C)cs1,,ClCCl,O,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20160229814A1,BrCC1CC1.CCC1C(=O)NC(=O)c2cc([N+](=O)[O-])ccc21>>CCC1C(=O)N(CC2CC2)C(=O)c2cc([N+](=O)[O-])ccc21,,CN(C)C=O,,O,[H-].[Na+],val
US04360688,CI.O=C1CC(O)C=C1CCCCCC(C(O)=S)c1ccccc1>>COC(=S)C(CCCCCC1=CC(O)CC1=O)c1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080234314A1,O=[N+]([O-])c1cc2c(cc1[N+](=O)[O-])OCO2>>Nc1cc2c(cc1[N+](=O)[O-])OCO2,,CC(=O)O,,,,val
US20060014777A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@@H]1CN(Cc2ccccc2)C[C@@H]1c1cccc(C(F)(F)F)c1C(=O)OC(C)C>>COC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1cccc(C(F)(F)F)c1C(=O)OC(C)C,[Pd],CCO,,[H][H],,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC(OCCO)CC2)c2ncnn12.CI>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC(OCCOC)CC2)c2ncnn12,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20160272617A1,CCN(CC)C1CCC(N)CC1.Cc1cc(C(=O)O)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3c(Cl)n[nH]c3c2)cc1>>CCN(CC)C1CCC(NC(=O)c2ccc(-c3ccc(C[C@H](NC(=O)[C@@H]4CC[C@@H](CNC(=O)OC(C)(C)C)CC4)C(=O)Nc4ccc5c(Cl)n[nH]c5c4)cc3)c(C)c2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140073620A1,CC(C(N)=O)c1ccccc1C#Cc1nc(Cl)ncc1Cl>>CC(C(N)=O)c1ccccc1CCc1nc(Cl)ncc1Cl,O=[Pt],CCOC(C)=O,CN(C)C=O,CO,,val
US20030158202A1,O=S(=O)(Cl)c1ccc(F)c2ccccc12.O=S(=O)(c1ccc(F)c2ccccc12)N1CCCc2ccccc21.c1ccc2c(c1)CCCN2.c1ccncc1>>Cl.O=S(=O)(c1ccc(N2CCNCC2)c2ccccc12)N1CCCc2ccccc21,,ClCCl,,,,val
US20130005973A1,Brc1n[nH]c(Br)n1.O=C(CCl)c1ccc(F)cc1F>>O=C(Cn1nc(Br)nc1Br)c1ccc(F)cc1F,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20090176847A1,CC(C)(C)NC(=O)OC1CC2CC(N(CC(=O)N3CCCC3C#N)C(=O)OC(C)(C)C)CC2C1.Cl>>CC(C)(C)NC(=O)OC1CC2CC(NCC(=O)N3CCCC3C#N)CC2C1.Cl,,CCOCC,,ClCCl,,val
US04640916,COC(=O)C(Br)CCBr.COc1ccc(N)c(S)c1>>COc1ccc2c(c1)SC(CCBr)C(=O)N2,,CN(C)C=O,,,,val
US20120077797A1,CC(C)(C)OC(=O)NCCN.O=C1CN(C(=O)c2cc3ccc(C(F)(F)F)cc3s2)C1>>CC(C)(C)OC(=O)NCCNC1CN(C(=O)c2cc3ccc(C(F)(F)F)cc3s2)C1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20020193367A1,CN(C)Cc1cnnn1-c1cccc(C(=O)CC(=O)Nc2cc(Cl)c(N(C)C)cc2NC(=O)OC(C)(C)C)c1>>CN(C)Cc1cnnn1-c1cccc(C2=Nc3cc(N(C)C)c(Cl)cc3NC(=O)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160251321A1,Cc1cc(F)c(-n2nc(C(=O)O)c(=O)[nH]c2=O)cc1SCC(F)(F)F>>Cc1cc(F)c(-n2ncc(=O)[nH]c2=O)cc1SCC(F)(F)F,,c1ccc(Oc2ccccc2)cc1,,,,val
US20120071512A1,Cn1c(=O)n(C)c2cc(Br)ccc21.OB(O)c1cccnc1>>Cn1c(=O)n(C)c2cc(-c3cccnc3)ccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US04840883,CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)Cl.Nc1cc(Cl)c([N+](=O)[O-])cc1O>>CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)Nc1cc(Cl)c([N+](=O)[O-])cc1O,,CCOC(C)=O,,,,val
US05155251,CC(=O)OC(C)(C)C.CCCCOC(=O)C[C@H](O)CC#N>>CC(C)(C)OC(=O)CC(=O)C[C@H](O)CC#N,,C1CCOC1,CCOC(C)=O,Cl,CC(C)[N-]C(C)C.[Li+],val
US20120129104A1,O=C(Cl)C(=O)Cl.O=C(O)CCC(F)(F)C(F)(F)Br>>O=C(Cl)CCC(F)(F)C(F)(F)Br,,ClCCl,,CN(C)C=O,,val
US05639752,CN(C)CCc1c[nH]c2ccc(Nc3ncccc3N)cc12.O=C(Cl)c1ccccc1>>CN(C)CCc1c[nH]c2ccc(Nc3ncccc3NC(=O)c3ccccc3)cc12,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US06583141B1,ClP(Cl)(Cl)(Cl)Cl.N#CC(O)(c1ccccc1)c1ccc(NC(=O)C2CC(c3cccnc3)=NO2)cc1>>Cl.N#CC(Cl)(c1ccccc1)c1ccc(NC(=O)C2CC(c3cccnc3)=NO2)cc1,,C1CCOC1,,CCOCC,,val
US20110118245A1,COCCOc1cc2ncnc(Sc3cccc(N)c3)c2cc1OC.O=C(Nc1cc(C(F)(F)F)nn1-c1ccc(F)cc1)Oc1ccccc1>>COCCOc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(C(F)(F)F)nn4-c4ccc(F)cc4)c3)c2cc1OC,CN(C)c1ccncc1,C1CCOC1,,,,val
US20020077316A1,CCOC(=O)C(C)(C)CCCSCSCCCC(C)(C)C(=O)O>>CC(C)(CCCSCSCCCC(C)(C)C(=O)O)C(=O)O,,CCO,O,[Na+].[OH-],,val
US20160083343A1,Cc1ccc(C(=O)N2CCCC[C@H]2CO)cn1.O=Cc1c(O)cccc1O>>Cc1ccc(C(=O)N2CCCC[C@H]2COc2cccc(O)c2C=O)cn1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05095113,CNC(C)=O.N#C[N-]C#N.O=C(Cl)Cl>>Cc1nc(Cl)nc(Cl)n1,,Cc1ccccc1,,Cl,,val
US20060211727A1,COc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3ccccc3Cl)c2c1>>O=c1ccc2c(-c3ccccc3Cl)cc(O)cc2n1-c1ccccc1Cl,,ClCCl,,BrB(Br)Br,,val
US20080004455A1,CCOC(=O)c1ccc(I)cc1>>OCc1ccc(I)cc1,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US05236952,CS(=O)(=O)O.O=C(c1ccncc1)c1cc(O)c(O)c([N+](=O)[O-])c1>>CS(=O)(=O)O.O=C(c1ccncc1)c1cc(O)c(O)c([N+](=O)[O-])c1,,CO,,,,val
US20040063954A1,N#CC=C1CCN(c2ccc(N3C[C@@H](CN=[N+]=[N-])OC3=O)cc2)CC1>>N#CC=C1CCN(c2ccc(N3C[C@H](CN)OC3=O)cc2)CC1,,O,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06583133B1,CCOC(=O)CBr.COc1ccc(-c2ccc(S)cc2)cc1>>COc1ccc(-c2ccc(SCC(=O)O)cc2)cc1,,CCO,O,Cl,[K+].[OH-],val
US20060069106A1,CCOc1ccc(-n2c([C@@H](C)N(CCC(C)N(C)C3CCC3)C(=O)Cc3ccc(F)c(C(F)(F)F)c3)nc3ncccc3c2=O)cc1>>CCOc1ccc(-n2c([C@@H](C)N(CCC(C)N(C)C3CCC3)C(=O)Cc3ccc(F)c(C(F)(F)F)c3)nc3c(c2=O)CCCN3)cc1,,CO,,,,val
US20100273744A1,O=C(O)c1ccc(Oc2ccccc2)cc1C(F)(F)F>>OCc1ccc(Oc2ccccc2)cc1C(F)(F)F,,C1CCOC1,,CO,,val
US04183923,CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](N5CC(O)C5)CC[C@]4(C)[C@H]3CC[C@]12C.CCCCCCCCCCCCCCCCS(=O)(=O)Cl>>CCCCCCCCCCCCCCCCS(=O)(=O)OC1CN([C@@H]2CC[C@@]3(C)[C@@H](CC[C@H]4[C@@H]5CC[C@H]([C@H](C)CCCC(C)C)[C@@]5(C)CC[C@@H]43)C2)C1,,c1ccccc1,,CCN(CC)CC,,val
US20160095844A1,CN1C(=O)C(C)(C)c2ccc(-c3cnc(Cl)o3)cc21.CN1CCNCC1>>CN1CCN(c2ncc(-c3ccc4c(c3)N(C)C(=O)C4(C)C)o2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20150119362A1,CC(C)(C)OC(=O)N1CCN(c2cc(Nc3ccc(CC(N)=O)cc3)c3c(n2)CCC3)CC1.Cl>>Cl.NC(=O)Cc1ccc(Nc2cc(N3CCNCC3)nc3c2CCC3)cc1,,CO,,,,val
US20120040020A1,CC(C)(C)OC(=O)N1CC=C(c2cnc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(-c3nc4ccccc4n3C(=O)OC(C)(C)C)n2)CC1>>Nc1ncc(C2=CCNCC2)nc1-c1nc2ccccc2[nH]1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150191476A1,COC(=O)c1ncc(C2CC2)cn1>>OCc1ncc(C2CC2)cn1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04844727,CO.N#CCc1cc(Cl)nc(N)n1>>COc1cc(CC#N)nc(N)n1,,CO,,CC(=O)O,C[O-].[Na+],val
US20060025601A1,NO.O=C1CC2c3ccccc3CC12>>ON=C1CC2c3ccccc3CC12,,CO,,Cl,CC(=O)[O-].[Na+],val
US20080280855A1,C1CCNC1.CC(=O)c1csc2ccccc12>>C=C(c1csc2ccccc12)N1CCCC1,Cl[Ti](Cl)(Cl)Cl,CCCCCC,Cc1ccccc1,,,val
US20060019994A1,Cc1cc(OCC2CCNCC2)c2ccccc2n1.O=C1NC(=O)C(CCS(=O)(=O)Cl)N1>>Cc1cc(OCC2CCN(S(=O)(=O)CCC3NC(=O)NC3=O)CC2)c2ccccc2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130029961A1,N#Cc1ccc(C(F)(F)F)nc1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>N#Cc1ccc(C(F)(F)F)nc1OS(=O)(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20030191190A1,COc1ccc(CCN)cc1OC.O=C(Cl)C(=C(Cl)Cl)c1ccc(Cl)cc1>>COc1ccc(CCNC(=O)C(=C(Cl)Cl)c2ccc(Cl)cc2)cc1OC,,ClCCl,,CCN(CC)CC,,val
US20110112070A1,COc1ncc(Br)cc1NS(=O)(=O)C1CC1.Cc1nc(C(=O)Nc2cc([Sn](C)(C)C)cc3c2cnn3S(=O)(=O)c2ccccc2)cs1>>COc1ncc(-c2cc(NC(=O)c3csc(C)n3)c3cn[nH]c3c2)cc1NS(=O)(=O)C1CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,,CN(C)C=O,,val
US20150133453A1,CC(=O)O.CC(C)(N=[N+]=[N-])c1ccc(-c2nn3cccc3c(=O)[nH]2)cc1>>CC(C)(N)c1ccc(-c2nn3cccc3c(=O)[nH]2)cc1.O=CO,[Zn],C1CCOC1,,Cl,,val
US20020016328A1,CCC(COS(C)(=O)=O)Nc1cc(C)nc(Oc2c(C)cc(OC)cc2C)c1C(=O)OC.CS(C)=O>>CCC(CSC)Nc1cc(C)nc(Oc2c(C)cc(OC)cc2C)c1C(=O)OC,,CC#N,,[I-].[Na+],,val
US05476933,COc1cc(=O)c2cc(C)cc(C)c2[nH]c1=O>>Cc1cc(C)c2[nH]c(=O)c(O)cc(=O)c2c1,,ClCCl,,CCO,,val
US20070225332A1,COc1ccc(Oc2nnc(Br)s2)cc1>>Oc1ccc(Oc2nnc(Br)s2)cc1,,ClCCl,,BrB(Br)Br,,val
US20060247228A1,CC1=C2OC(C)(C(=O)N3CCc4c([nH]c5ccccc45)C3)CC2C(C)C([N+](=O)[O-])=C1C>>Cc1c(C)c2c(c(C)c1N)CC(C)(C(=O)N1CCc3c([nH]c4ccccc34)C1)O2,[Zn],CCO,,[Ca+2].[Cl-].[Cl-],,val
US20070088143A1,COC(F)(F)C(F)(F)CO.FC(F)=C(F)F>>COC(F)(F)C(F)(F)COC(F)=C(F)F,,CCOCC,,[H-].[Na+],,val
US20160264567A1,O=Cc1cc(Cl)nc(C2CC2)c1C(F)(F)F>>OCc1cc(Cl)nc(C2CC2)c1C(F)(F)F,,CO,,[BH4-].[Na+],,val
US04503043,CC(C)(C)O.CCOCC.Cc1ccccc1CC(=O)Cl.O=C(Cl)C(Br)c1ccccc1CBr.c1ccncc1>>CC(C)(C)OC(=O)C(Br)c1ccccc1CBr.CC(C)(C)OC(=O)C1NCC2CCCCC21.Cl,,CCOCC,,,,val
US20050282863A1,ClCCCCBr.c1ccc2c(c1)SCCc1c-2[nH]c2ccccc12>>ClCCCCn1c2c(c3ccccc31)CCSc1ccccc1-2,,CN(C)C=O,,O,[H-].[Na+],val
US20070054909A1,CC(C)(C)OC(=O)N1CCCC1(C)CO.COC(=O)c1ccc(O)c([N+](=O)[O-])c1>>COC(=O)c1ccc(OCC2(C)CCCN2)c([N+](=O)[O-])c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05561150,CC1=C2C=c3c(cnn3C[C@H](C)N=[N+]=[N-])=C2C(C)(C)C=C1.O=C(O)/C=C/C(=O)O>>CC1=C2C=c3c(cnn3C[C@H](C)N)=C2C(C)(C)C=C1.O=C(O)/C=C/C(=O)O,O=[Pt],CCOCC,CO,,,val
US20050143391A1,CC(C)(C)OC(=O)N1CCC(CO)CC1.Oc1ccncc1>>CC(C)(C)OC(=O)N1CCC(COc2ccncc2)CC1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140275021A1,COc1ccncc1NC(=O)C(C#N)=C(N)C(Cl)(Cl)Cl.NN>>COc1ccncc1NC(=O)c1c(N)n[nH]c1N,,CN1CCCC1=O,,O,,val
US20070244170A1,CCCc1ccc(C=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1.OO>>CCCc1ccc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,[Na+],[OH-],Cl,,val
US05731435,COC(CBr)OC.N#CC(CCN1CCCCC1)c1ccccc1Cl>>COC(CC(C#N)(CCN1CCCCC1)c1ccccc1Cl)OC,,CS(C)=O,,[K+].[OH-],,val
US07468382B2,CC(C)(C)OC(=O)N1CCC(CNc2cc(NCc3ccccc3OC(F)(F)F)ncc2[N+](=O)[O-])CC1>>O=[N+]([O-])c1cnc(NCc2ccccc2OC(F)(F)F)cc1NCC1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100298221A1,NC(=O)c1c(C(F)(F)F)cc(-c2cc(F)cc(F)c2)nc1Cl.Oc1ccccc1Cl>>NC(=O)c1c(C(F)(F)F)cc(-c2cc(F)cc(F)c2)nc1Oc1ccccc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050250948A1,Cn1c(C(=O)c2ccc(Br)cc2)cnc1SCCCN1CCCCC1>>Cn1c(C=O)cnc1SCCCN1CCCCC1,O=[Mn]=O,,,,,val
US05604242,CCOC(=O)[C@@H]1CCCN(CCOCCN(CC(C)C)c2ccc(F)cc2Cl)C1.Cl>>CC(C)CN(CCOCCN1CCC[C@@H](C(=O)O)C1)c1ccc(F)cc1Cl.Cl,,CCO,,[Na+].[OH-],,val
US20130331378A1,COC(=O)c1cccc(C=O)n1.C[Si](C)(C)c1c(Cl)ccc2c(Br)c(-c3ccccc3)nn12>>COC(=O)c1cccc(C(O)c2c(-c3ccccc3)nn3c([Si](C)(C)C)c(Cl)ccc23)n1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20120094979A1,CCc1c(Br)cccc1CCN.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCc1c(Br)cccc1CCNC(=O)C(F)(F)F,,O,,CCN(CC)CC,ClCCl,val
US20130281433A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(Br)sc2c1-c1ccc(Cl)cc1.OB(O)c1ccc(Br)cc1>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccc(Br)cc3)sc2c1-c1ccc(Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20130172292A1,CI.c1ccc(COc2ccc(-c3n[nH]c4cccnc34)cc2)cc1>>Cn1nc(-c2ccc(O)cc2)c2ncccc21,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US06040339,CCCCCC(CC(=O)OC)c1ccc(O)cc1OC.[Cl-]>>CCCCCC(CC(=O)OC)c1cc(Cl)c(O)cc1OC,,CCOC(C)=O,c1ccccc1,,,val
US05137911,OC(c1ccc(F)cc1)c1ccc(F)cc1.OCCCl>>Fc1ccc(C(CCCl)c2ccc(F)cc2)cc1,,Cc1ccccc1,,O=S(=O)(O)O,,val
US20120238588A1,CC(C)(C)N(C(=O)[O-])c1cc2ccccc2c(-c2cnc3[nH]cc(Br)c3c2)n1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)Nc1cc2ccccc2c(-c2cnc3c(c2)c(Br)cn3C(=O)OC(C)(C)C)n1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20130085164A1,CC(O)c1ccc(-c2ccc(F)cc2)cn1.O=C(n1ccnc1)n1ccnc1>>CC(c1ccc(-c2ccc(F)cc2)cn1)n1ccnc1,,CCOC(C)=O,CN1CCCC1=O,,,val
US05834506,CCCCC(=O)CCc1ccc(OCc2ccccc2)cc1.COC(=O)CC(C)=O>>CCCCC1(CCc2ccc(O)cc2)CC(O)=CC(=O)O1,,C1CCOC1,,[Li]CCCC,[H-].[Na+],val
US05462954,COC([O-])[O-].O=C1CCc2ccccc2C1>>COC1=Cc2ccccc2CC1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04385176,CC1C=C(C(=O)O)N2C(=O)C(NC(=O)C(NOC(C)C3CC3)C3=CCCOC3=C=O)[C@H]2S1>>CC1C=C(C(=O)O)N2C(=O)C(NC(=O)C(N)C3=CCCOC3)[C@H]2S1,,O=CO,,,,val
US03988448,CCOC(=O)Cl.c1ccc(CN2CCOC(c3ccccc3)(c3ccccc3)CC2)cc1>>CCOC(=O)N1CCOC(c2ccccc2)(c2ccccc2)CC1,,ClCCl,,,,val
US06096710,CCCC[C@H](NC(=O)CNC(=O)OC(C)(C)C)C(=O)OCC>>CCCC[C@H](NC(=O)CNC(=O)OC(C)(C)C)C(=O)O,,C1CCOC1,O,[K+].[OH-],,val
US04772600,Nc1cccnc1.O=C(Cl)C(=O)Cl.O=C(O)Cn1c(-c2cccc(Cl)c2)nc2cccnc21>>Cl.O=C(Cn1c(-c2cccc(Cl)c2)nc2cccnc21)Nc1cccnc1,,CN(C)C=O,,CCN(CC)CC,,val
US04204870,O=C(Oc1c(N=Nc2ccccn2)cc(S(=O)(=O)O)c2ccccc12)c1ccccc1.O=S(Cl)Cl>>O=C(Oc1c(N=Nc2ccccn2)cc(S(=O)(=O)Cl)c2ccccc12)c1ccccc1,,CN(C)C=O,,,,val
US20120028960A1,COC(=O)C(c1ccccc1)C1CCCCN1>>COC(=O)[C@H](c1ccccc1)[C@H]1CCCCN1,,O,,Cl,[NH4+].[OH-],val
US04616086,CCCCOC(=O)c1ccc(CCN2CCN(Cc3ccccc3Cl)CC2)cc1.O=C(O)c1ccc(CCN2CCN(Cc3ccccc3Cl)CC2)cc1>>CCOC(=O)Cc1ccc(CCN2CCNCC2)cc1,,CCCCO,,,,val
US20140256734A1,CC(C)(C)OC(=O)N1CCC[C@@H]1COc1nc(C#N)cc2ccccc12.CCOC(=O)NN>>CC(C)(C)OC(=O)N1CCC[C@@H]1COc1nc(-c2n[nH]c(=O)[nH]2)cc2ccccc12,,CCOC(C)=O,,CN1CCCC1=O,,val
US20160207883A1,COc1cc([N+](=O)[O-])c(Br)cn1>>COc1cc(N)c(Br)cn1,[Fe],CC(=O)O,,,,val
US20130237525A1,COc1cccc(OCc2ccccc2)c1C1CC=CC(=O)N1Cc1ccc(OC(F)(F)F)cc1>>COc1cccc(O)c1C1CCCC(=O)N1Cc1ccc(OC(F)(F)F)cc1,,CCO,,,,val
US20090048249A1,COCc1cccc2c1nc(-c1nn(COCC[Si](C)(C)C)c3ncc(B4OC(C)(C)C(C)(C)O4)cc13)n2COCC[Si](C)(C)C.Cc1ccncc1Br>>COCc1cccc2c1nc(-c1nn(COCC[Si](C)(C)C)c3ncc(-c4cnccc4C)cc13)n2COCC[Si](C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20090270405A1,COc1ccc(CN)c(OC)c1.Cc1ccc2nc(Cl)cnc2c1>>COc1ccc(CNc2cnc3cc(C)ccc3n2)c(OC)c1,,CS(C)=O,,CCOC(C)=O,,val
US20120196864A1,CCN1C(=N)/C(=C/c2ccc(Oc3ccc(C(F)(F)F)cc3C(F)(F)F)c(OC)c2)NC1=O.CI>>CCN1C(=N)/C(=C/c2ccc(Oc3ccc(C(F)(F)F)cc3C(F)(F)F)c(OC)c2)N(C)C1=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160039838A1,C1CO[C@H]2CNC[C@H]2O1.O=C(/C=C/CBr)Nc1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1>>O=C(/C=C/CN1C[C@H]2OCCO[C@H]2C1)Nc1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,O,val
US20120232056A1,COC(=O)c1ccc2nc(-c3coc4ccccc34)c(N3CCC[C@@H]3C)nc2c1>>C[C@H]1CCCN1c1nc2cc(C(=O)O)ccc2nc1-c1coc2ccccc12,,CO,O,[Na+].[OH-],,val
US06441017B1,CC(C)(C)OC(=O)N[C@H]1CCN(c2ccccc2-c2cccc(O[Si](C)(C)C(C)(C)C)c2)C1=O>>CC(C)(C)[Si](C)(C)Oc1cccc(-c2ccccc2N2CC[C@H](N)C2=O)c1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US06083955,CCCc1cc(C(=O)OC)ccc1Oc1c(Cl)nc(-c2ncccn2)nc1NS(=O)(=O)C=Cc1ccccc1.CO>>CCCc1cc(C(=O)OC)ccc1Oc1c(NS(=O)(=O)C=Cc2ccccc2)nc(-c2ncccn2)nc1OC,,Cl,,[Na],,val
US20010018525A1,O=C1CCC(=O)N1Br.OCCCCc1ccccc1>>BrCCCCc1ccccc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120172382A1,CCOC(=O)c1cn(C)cc(-c2ccc(F)cc2)c1=O>>Cn1cc(C(=O)O)c(=O)c(-c2ccc(F)cc2)c1,,O,,[Na+].[OH-],,val
US20060047001A1,CC(=O)c1csc2ccccc12.NC=O>>CC(NC=O)c1csc2ccccc12,,O,,O=CO,,val
US20120108619A1,CN.O=C(O)c1cc(Br)ccc1F>>CNC(=O)c1cc(Br)ccc1F,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US05338740,CCCCc1nc2cccnc2n1-c1cccc2cc([Sn](CCCC)(CCCC)CCCC)ccc12.COC(=O)c1ccccc1I>>CCCCc1nc2cccnc2n1-c1cccc2cc(-c3ccccc3C(=O)OC)ccc12,,CN(C)C=O,,O,,val
US20050038073A1,Cc1ccccc1C(=O)c1cnc(NCCC2CCCCN2)s1.O=S(=O)(Cl)c1ccsc1>>Cc1ccccc1C(=O)c1cnc(NCCC2CCCCN2S(=O)(=O)c2ccsc2)s1,,CO,ClCCl,CCN(CC)CC,Cl,val
US20110257151A1,COC(=O)c1ccc2c(c1)C(O)C(C)(C)C(c1cc(Cl)cc([N+](=O)[O-])c1)N2>>COC(=O)c1ccc2c(c1)CC(C)(C)C(c1cc(Cl)cc([N+](=O)[O-])c1)N2,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(F)cc23)cc1.Nc1ccc(N2CCOCC2)cc1>>Fc1ccc2nc(Nc3ccc(N4CCOCC4)cc3)c3[nH]ncc3c2c1,C1COCCO1,CO,,Cl,,val
US05911913,CCCCCCCCBr.CCCCCCCCOc1cc2ccc(-c3ncc(O)cn3)cc2c(F)n1>>CCCCCCCCOc1cnc(-c2ccc3cc(OCCCCCCCC)nc(F)c3c2)nc1,,CN(C)C=O,,O,[H-].[Na+],val
US20100120880A1,CI.Cc1csc2nc3ccc(C(F)(F)F)cc3n12>>Cc1csc2n1c1cc(C(F)(F)F)ccc1[n+]2C.[I-],,CC(C)=O,,,,val
US20160060273A1,CCI.CCOc1cc(C(=O)O)c(Br)cc1F>>CCOC(=O)c1cc(OCC)c(F)cc1Br,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06207708B1,CC(N)(CCCN)C(=O)O.Cl.ON=CCCl>>CC(=NO)NCCCC(C)(N)C(=O)O.Cl.Cl,,O,,,,val
US05864039,CC(=O)Cl.CC(C)(C)OC(=O)NCC1CCN(CCN)C1>>CC(=O)NCCN1CCC(CNC(=O)OC(C)(C)C)C1,,ClCCl,,CCN(CC)CC,,val
US20140235446A1,N#CC(c1cccc(F)c1)C(CC(=O)O)c1ccc(F)cc1.O=C1CCCC(=O)C1>>N#CC(c1cccc(F)c1)C(CC(=O)OC1=CC(=O)CCC1)c1ccc(F)cc1,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20120053180A1,Cc1ncn(-c2ccc(N)cc2)n1.O=S(=O)(O)O>>Cc1ncn(-c2ccc(O)cc2)n1,,O,O=S(=O)(O)O,O=N[O-].[Na+],,val
US05739116,CCOC(=O)CCCOc1ccc(CCC(C)=O)cc1>>CC(=O)CCc1ccc(OCCCC(=O)O)cc1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20100093724A1,CS(=O)(=O)c1cc([C@H](CC(O)CO)NC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1>>CS(=O)(=O)c1cc([C@H](CC=O)NC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1,,CC(C)=O,O,,,val
US20060287322A1,O=c1cc(-c2ccc(Cl)cc2)c(-c2ccccc2Cl)nn1Cc1ccccc1>>O=c1cc(-c2ccc(Cl)cc2)c(-c2ccccc2Cl)n[nH]1,,Cc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20110190342A1,N[C@@H](Cc1ccc(Oc2ccnc(Cl)c2)cc1)C(=O)O.O=C(O)c1cc2cc(Cl)ccc2nc1Cl>>O=C(O)c1cc2cc(Cl)ccc2nc1N[C@@H](Cc1ccc(Oc2ccnc(Cl)c2)cc1)C(=O)O,,CS(C)=O,,,,val
US20110224204A1,C1=COCCC1.Oc1ccccc1I>>Ic1ccccc1OC1CCCCO1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20070213341A1,CC=C(CC)C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12>>CCC(CC)C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12,O=[Pt],CCOC(C)=O,,,,val
US06441017B1,COc1ccc2cccc([N+](=O)[O-])c2n1>>COc1ccc2cccc(N)c2n1,,CCO,,,,val
US20140213580A1,CC(=O)C(C)C.COC(OC)N(C)C>>CC(C)C(=O)C=CN(C)C,,CN(C)C=O,,,,val
US20080188528A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)[C@H](CCCN)NC(=O)c1cccn(C(c2ccccc2)c2ccccc2)c1=O>>CC(=O)NCCC[C@H](NC(=O)c1cccn(C(c2ccccc2)c2ccccc2)c1=O)C(=O)OC(C)(C)C,,CCOC(C)=O,c1ccncc1,,,val
US05700761,C#CCOc1cc(N)c(F)cc1Cl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C#CCOc1cc(N=C=O)c(F)cc1Cl,,ClCCl,,CCN(CC)CC,,val
US20030125370A1,Cc1[nH]c(C=O)c(C)c1C(=O)N1CCN(C)CC1.O=C1Cc2cc(S(=O)(=O)Cc3ccccc3OCCN3CCOCC3)ccc2N1>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4ccccc4OCCN4CCOCC4)cc32)c(C)c1C(=O)N1CCN(C)CC1,C1CCNCC1,CCO,,,,val
US20050090516A1,CCOC(=O)N1C(=O)c2ccccc2C1=O.COc1ccc(C(C)N)cc1OC>>COc1ccc(C(C)N2C(=O)c3ccccc3C2=O)cc1OC,,CC#N,O,O=C([O-])[O-].[Na+].[Na+],,val
US20030144274A1,CC(C)(C)OC(=O)c1ccc(CN)cc1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CC(C)(C)OC(=O)c1ccc(CNS(=O)(=O)c2ccccc2[N+](=O)[O-])cc1,,ClCCl,,CCN(CC)CC,,val
US04997942,CCCCCCCc1ccc(C2CN(C(C)=S)CCO2)cc1.OCCOCCOCCO.[OH-]>>CCCCCCCc1ccc(CC(=O)O)cc1,,O,,Cl,,val
US20150329548A1,Cc1ccc(S(=O)(=O)OS(=O)(=O)c2ccc(C)cc2)cc1.Cc1cccc(C(=O)CC#N)c1>>Cc1ccc(S(=O)(=O)O/C(=C/C#N)c2cccc(C)c2)cc1,,ClCCl,,,,val
US20110015388A1,C=CCC(CC=C)(CC=C)c1ccc(C=O)cc1.CCCn1c(-c2ccccc2)nc2cc(C#N)c(C#N)cc21>>C=CCC(CC=C)(CC=C)c1ccc(-c2nc3cc(C#N)c(C#N)cc3[nH]2)cc1,,CCOC(C)=O,CN1CCCC1=O,,,val
US05286902,C=C(C)c1ccc2cc(OC)ccc2c1.O=[Se]=O>>C=C(CO)c1ccc2cc(OC)ccc2c1,,ClCCl,,,,val
US20130310419A1,CCC(=O)C(CC(=O)c1ccc2c(c1)C(C)(C)CCO2)C(C)=O.Nc1ccc(S(N)(=O)=O)cc1>>CCC(=O)c1cc(-c2ccc3c(c2)C(C)(C)CCO3)n(-c2ccc(S(N)(=O)=O)cc2)c1C,,CC(=O)O,ClC(Cl)Cl,N,,val
US05968985,CN(C)CCN.COC(=O)c1cc(C(=O)O)cc(-c2cc(Cl)sc2Cl)c1>>COC(=O)c1cc(C(=O)NCCN(C)C)cc(-c2cc(Cl)sc2Cl)c1,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20150210697A1,CI.COc1ccc(CN(c2nc(Nc3cc(C#N)cc(N4CCC(NC5CC(=O)N(C)C5)CC4)c3Cl)nn3c(C#N)cnc23)C2CC2)cc1>>CN1CC(N(C)C2CCN(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)CC1=O,,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120309698A1,CCOC(=O)C1CC(C(=O)OCC)(C(=O)OCC)CCC1=O>>CCOC(=O)C1(C(=O)OCC)CCC(=O)CC1,,CS(C)=O,,O,[Cl-].[Na+],val
US20150252059A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)C1=N[C@](C)(c2cc([N+](=O)[O-])ccc2F)CS(=O)(=O)C1(CF)CC=O>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)C1=N[C@](C)(c2cc([N+](=O)[O-])ccc2F)CS(=O)(=O)C1(CF)CCO,,C1CCOC1,,B,,val
US20090182007A1,CC(C)O.CC1(C)OC(=O)c2ccccc2C1n1cncc1C(=O)O>>CC(C)OC(=O)c1cncn1C1c2ccccc2C(=O)OC1(C)C,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20060004077A1,Clc1ccccc1C(Cl)(c1ccccc1)c1ccccc1.O=C(O)[C@@H]1C(c2ccccc2)CCN1C(=O)OCC1c2ccccc2-c2ccccc21>>O=C(OCC1c2ccccc2-c2ccccc21)N1CCCCC1,,ClCCl,,CCN(C(C)C)C(C)C,CO,val
US20140128429A1,Brc1cncn1C1CC1.N#Cc1ccc(C=O)cc1>>N#Cc1ccc(C(O)c2cncn2C2CC2)cc1,,ClCCl,,CC(C)[Mg]Cl,,val
US20130217699A1,COC(=O)c1sc(C(=O)C=C(c2cc(Cl)c(F)c(Cl)c2)C(F)(F)F)c2c1CCC2.NO>>COC(=O)c1sc(C2=NOC(c3cc(Cl)c(F)c(Cl)c3)(C(F)(F)F)C2)c2c1CCC2,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20090209522A1,C[Si](C)(C)CCOCn1ccnc1CN1C(=O)c2ccccc2C1=O>>C[Si](C)(C)CCOCn1ccnc1CN,,CCO,,NN,O,val
US20030236280A1,COCOc1ccc(CN=C=S)cc1OC.COc1ccc2c(c1)CC[C@H](N)[C@@H]2Cc1ccccc1>>COCOc1ccc(CNC(=S)NC2CCc3cc(OC)ccc3C2Cc2ccccc2)cc1OC,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20120214803A1,O=[N+]([O-])c1cc(Cl)ccc1S(=O)(=O)Nc1cccc2c(C(F)(F)F)ccnc12>>Nc1cc(Cl)ccc1S(=O)(=O)Nc1cccc2c(C(F)(F)F)ccnc12,Cl,CCO,,Cl[Sn]Cl,,val
US20150183781A1,Fc1ccccc1CBr.Ic1cn[nH]c1>>Fc1ccccc1Cn1cc(I)cn1,,CCCCCC,CN(C)C=O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US06531511B1,CCc1cccc(C2(C#N)C3CC4CC(C3)CC2C4)c1.Cl>>CCc1cccc(C2(CN)C3CC4CC(C3)CC2C4)c1.Cl,,C1CCOC1,,,,val
US20060135447A1,O=P(Cl)(Cl)Cl.O=S(=O)(O)c1cnc2ccccn12>>O=S(=O)(Cl)c1cnc2ccccn12,,ClCCl,,,,val
US20060281768A1,CC(C)c1ccc(N)cc1.O=C(n1ccnc1)n1ccnc1.OC1CCN(c2ncnc3sccc23)CC1>>CC(C)c1ccc(NC(=O)OC2CCN(c3ncnc4sccc34)CC2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20060135530A1,O=C(Cl)C(=O)Cl.O=C(O)CNC(=O)OCc1ccccc1>>O=C(Cl)CNC(=O)OCc1ccccc1,,C1CCOC1,,CN(C)C=O,,val
US05227490,CC(C)(C)OC(=O)N1CCC(CCCCOc2ccc(Br)cc2)CC1.CCCC[Sn](Cl)(CCCC)CCCC>>CCCC[Sn](CCCC)(CCCC)c1ccc(OCCCCC2CCN(C(=O)OC(C)(C)C)CC2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20140275011A1,NCC1CCOCC1.O=[N+]([O-])c1cc(Cl)c(Br)cc1F>>O=[N+]([O-])c1cc(Cl)c(Br)cc1NCC1CCOCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04258058,CCOC(=O)COc1ccc(CCN)cc1.COc1ccc(S(=O)(=O)Cl)cc1>>COc1ccc(S(=O)(=O)NCCc2ccc(OCC(=O)O)cc2)cc1,,c1ccncc1,,,,val
US20090227609A1,CC(=N)SCc1ccc2ccccc2c1.Nc1ccc2nc(-c3ccc4c(c3)OCO4)ncc2c1>>CC(=N)Nc1ccc2nc(-c3ccc4c(c3)OCO4)ncc2c1,,CCO,,,,val
US05350748,COc1ccc2sc(C(N)=O)c(S)c2c1.O=C(O)CBr>>COc1ccc2sc(C(N)=O)c(SCC(=O)O)c2c1,,C1CCOC1,CCOC(C)=O,O=C([O-])O.[Na+],,val
US20060128732A1,N#CBr.Nc1ccccc1C1=NCCN1>>Br.NC1=Nc2ccccc2C2=NCCN12,,CO,,,,val
US04840662,CSc1ncnc(SC)c1N.O=[N+]([O-])c1cc(C(F)(F)F)c(Cl)c([N+](=O)[O-])c1Cl>>CSC1=NCN(c2c([N+](=O)[O-])cc(C(F)(F)F)c(Cl)c2[N+](=O)[O-])C(SC)=C1N,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20030069273A1,NNCc1ccccc1.O=c1nc(-c2ccccc2O)oc2ccccc12>>Oc1ccccc1-c1nc(-c2ccccc2O)n(Cc2ccccc2)n1,,CCO,,CCN(CC)CC,Cl,val
US20160016903A1,CCCC(=O)Cl.CN(C)C1(c2ccccc2)CCC2(CCNC2)CC1>>CCCC(=O)N1CCC2(CCC(c3ccccc3)(N(C)C)CC2)C1,,ClCCl,,CCN(CC)CC,,val
US06090833,NC(=S)c1ccncc1.O=C1c2ccc(Cl)cc2CC1Br>>OC12N=C(c3ccncc3)SC1Cc1cc(Cl)ccc12,,CC(C)=O,,CCN(CC)CC,,val
US20140011800A1,CC(C)(C)OC(=O)N1CCC(=O)C(C)(C)C1.C[C@@H](N)c1ccccc1>>C[C@@H](/N=C1\CCN(C(=O)OC(C)(C)C)CC1(C)C)c1ccccc1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,CCN(CC)CC,CCOCC,val
US04746669,N#CCc1ccc[nH]1.S>>CC(=S)Nc1ccc[nH]1,,c1ccncc1,,CCN(CC)CC,,val
US20080132546A1,CCNC(=O)Nc1cc(-c2cncc(F)c2)c(-c2cncc(C(=O)OCC)c2)cn1>>CCNC(=O)Nc1cc(-c2cncc(F)c2)c(-c2cncc(C(=O)O)c2)cn1,,C1CCOC1,,[Li+].[OH-],,val
US20160002215A1,O=[N+]([O-])c1cc(F)cc(C(F)(F)F)c1.OCCN1CCOCC1>>O=[N+]([O-])c1cc(OCCN2CCOCC2)cc(C(F)(F)F)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130203758A1,CC(C)(CN)CNC(=O)c1ccc(Nc2nc(NC3(c4ccc(Cl)cc4)CC3)nc(OCC(F)(F)F)n2)c(F)c1.O=C(O)C(=O)N1CCCC1>>CC(C)(CNC(=O)C(=O)N1CCCC1)CNC(=O)c1ccc(Nc2nc(NC3(c4ccc(Cl)cc4)CC3)nc(OCC(F)(F)F)n2)c(F)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US04289883,C#CCOc1ccc(OCC(O)CCl)c2c1NC(=O)CC2.COc1ccc(CCN)cc1OC>>C#CCOc1ccc(OCC(O)CNCCc2ccc(OC)c(OC)c2)c2c1NC(=O)CC2.Cl,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20160228450A1,CC(C)(C)OC(=O)N1CCC(c2ccc(CC#N)cc2)CC1.Cl>>Cl.N#CCc1ccc(C2CCNCC2)cc1,,C1COCCO1,,,,val
US03989701,CCC(=O)Cl.Nc1cc(C(=O)c2ccccc2)ccc1N1CCOCC1>>CCC(=O)Nc1cc(C(=O)c2ccccc2)ccc1N1CCOCC1.Cl,,CC(C)=O,,,,val
US20150376164A1,O=C(CC1CCNCC1)c1c[nH]c2ccc(OCc3ccccc3)cc12>>c1ccc(COc2ccc3[nH]cc(CCC4CCNCC4)c3c2)cc1,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20030060622A1,OC1OC[C@H](O)[C@H](O)[C@H]1F>>OC[C@@H]1OC(O)[C@H](F)[C@H]1O,,CO,,O=S(=O)(O)O,,val
US20160207928A1,CCOC(=O)N=C=S.Nc1cnc(Br)cn1>>CCOC(=O)NC(=S)Nc1cnc(Br)cn1,,C1COCCO1,,,,val
US20030114443A1,CC(C)(C)OC(=O)N1CCC(Cc2ccc([N+](=O)[O-])cc2)CC1>>CC(C)(C)OC(=O)N1CCC(Cc2ccc(N)cc2)CC1,,C1CCOC1,CO,NN,O,val
US05852016,CCS(=O)(=O)Nc1c(Cl)c(Cl)cc2nc(OC)c(OC)nc12.CI>>CCS(=O)(=O)N(C)c1c(Cl)c(Cl)cc2nc(OC)c(OC)nc12,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20160147144A1,C=C(C)C(=O)OC(=O)C(=C)C.OCCOc1ccc2c(c1)C(O)c1ccccc1S2>>C=C(C)C(=O)OCCOc1ccc2c(c1)C(O)c1ccccc1S2,,C1CCOC1,,CCN(CC)CC,O,val
US20150166564A1,CC(C)(C)OC(=O)N1C[C@@H](O)[C@H](N=[N+]=[N-])C1.Cl>>Cl.[N-]=[N+]=N[C@@H]1CNC[C@H]1O,,ClCCl,,C1COCCO1,,val
US20140057920A1,Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)O)cn1C1CCCC1.Cc1nnc(CN)o1>>Cc1nnc(CNC(=O)c2cn(C3CCCC3)c(C)c(-c3cccc(C(F)F)c3)c2=O)o1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120059000A1,FC(F)(F)c1cnc(Cl)nc1Cl.N>>Nc1ncc(C(F)(F)F)c(Cl)n1,,CO,,,,val
US05981572,Cc1ccc(F)c2occc12.O=C1CCC(=O)N1Br>>Fc1ccc(CBr)c2ccoc12,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20070208036A1,CC(=O)Nc1ccc(C(=O)C(C)Cl)cc1.CCOC(=O)CC(=O)OCC>>CCOC(=O)C(C(=O)OCC)C(C)C(=O)c1ccc(NC(C)=O)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100298347A1,CCOC(=O)c1cc(-c2ccsc2)c2ccc(O)cc2c1.Clc1ccc(Cl)c(CBr)c1Cl>>O=C(O)c1cc(-c2ccsc2)c2ccc(OCc3c(Cl)ccc(Cl)c3Cl)cc2c1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20090186909A1,CC(=O)Cl.Cc1cc(OCCCO)ccc1-c1cccc(COc2ccc(C=O)cc2)c1C>>CC(=O)OCCCOc1cc(C)c(-c2cccc(COc3ccc(C=O)cc3)c2)c(C)c1,,ClCCl,,CCN(CC)CC,,val
US20070149608A1,CCOCCCl.Cc1cc(O)cc(C)c1Br>>CCOCCOc1cc(C)c(Br)c(C)c1,,CN(C)C=O,,[I-].[K+],,val
US04634704,Fc1ccc(Cn2c(NC3CCN(CCN=C=S)CC3)nc3ccccc32)cc1.Nc1ccccc1NCc1ccc(Cl)c(Cl)c1>>Fc1ccc(Cn2c(NC3CCN(CCNC(=S)Nc4ccccc4NCc4ccc(Cl)c(Cl)c4)CC3)nc3ccccc32)cc1,,C1CCOC1,,,,val
US20060094767A1,FC(F)(F)Oc1ccc(NC2CCN(Cc3ccccc3)CC2)cc1>>FC(F)(F)Oc1ccc(NC2CCNCC2)cc1,[Pd],CCO,,[H][H],,val
US20140155398A1,CCOC(=O)[C@H](C)NC(=O)c1cc(Cl)c(C(=O)n2ccc3c(NC(=O)C4CC4)nccc32)c(Cl)c1>>C[C@H](NC(=O)c1cc(Cl)c(C(=O)n2ccc3c(NC(=O)C4CC4)nccc32)c(Cl)c1)C(=O)O,,C1CCOC1,O,[Na+].[OH-],,val
US20020156081A1,COCCN.COc1cc(-c2nn(-c3ccc(C=O)cc3)c3ncnc(N)c23)ccc1NC(=O)c1ccc(C(F)(F)F)cc1F>>COCCNCc1ccc(-n2nc(-c3ccc(NC(=O)c4ccc(C(F)(F)F)cc4F)c(OC)c3)c3c(N)ncnc32)cc1,,CC(Cl)Cl,,[Na+].[OH-],,val
US20100267795A1,CCC(C#N)OS(C)(=O)=O.O=[N+]([O-])c1cccc(O)c1Cl>>CCC(C#N)Oc1cccc([N+](=O)[O-])c1Cl,,CN1CCCC1=O,O,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20070027140A1,O=C(Nc1nccs1)c1cn(CC2CC2)c2cc(F)ccc12.O=C1CCC(=O)N1Br>>O=C(Nc1ncc(Br)s1)c1cn(CC2CC2)c2cc(F)ccc12,,CC(=O)O,,,,val
US20100183513A1,Cc1ccc(-c2csc(NC(=O)c3cnc(NC(=O)OC(C)(C)C)s3)n2)cc1>>Cc1ccc(-c2csc(NC(=O)c3cnc(N)s3)n2)cc1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20130102776A1,CC(c1c(O)ccc2c1OCC2=O)N1CCN(C(=O)OC(C)(C)C)CC1.O=Cc1n[nH]c2ccccc12>>CC(c1c(O)ccc2c1O/C(=C\c1n[nH]c3ccccc13)C2=O)N1CCN(C(=O)OC(C)(C)C)CC1,C1CCNCC1,CO,,Cc1ccccc1,,val
US20090234130A1,CC(C)(O)C#Cc1cccc(C(=O)c2ccc(F)cc2)c1>>C#Cc1cccc(C(=O)c2ccc(F)cc2)c1,,Cc1ccccc1,,[Na+].[OH-],,val
US20130217680A1,Cc1ccccc1.O=C(O)Cc1ccc(-n2cnnn2)cc1Br>>C=Cc1cc(-n2cnnn2)ccc1CC(=O)O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,[Cl-].[Li+],,val
US05312828,CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl.CCN(CC)C(=O)CCl>>CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)OCC(=O)N(CC)CC)n1Cc1ccccc1Cl,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120065192A1,CCc1cccc(CC)c1NC(=O)c1cc(-c2nc(Nc3ccc(C(=O)OC(C)(C)C)cc3C)ncc2C)n(C)c1>>CCc1cccc(CC)c1NC(=O)c1cc(-c2nc(Nc3ccc(C(=O)O)cc3C)ncc2C)n(C)c1,,ClCCl,O=C(O)C(F)(F)F,O,,val
US20120059028A1,COCC(C(=O)OC)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCC3>>C=C(C(=O)O)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCC3,,CO,,Cl,[Na+].[OH-],val
US20150353533A1,CC(C)(C)OC(=O)NC1CCc2cc(C#N)ccc2NC1=O>>N#Cc1ccc2c(c1)CCC(N)C(=O)N2,,ClCCl,,Cl,,val
US20080255083A1,Clc1ccccc1CN1CCC2SC=CC2C1.O=C(Cl)CCl>>O=C(CCl)C1=CC2CN(Cc3ccccc3Cl)CCC2S1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05192765,COC(=O)c1ccc(CCN(C)C(C)(C)COC(c2ccccc2)c2ccccc2)cc1>>CN(CCc1ccc(CO)cc1)C(C)(C)COC(c1ccccc1)c1ccccc1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120142653A1,C=C(C)[C@@H]1CC[C@]2(C(=O)N(CCO)CCN(C)C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OCCO)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(C(=O)N(CCO)CCN(C)C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1COCCO1,O,[Na+].[OH-],,val
US05889018,COc1cc2ccnc(C)c2cc1OC.O=Cc1c(Cl)cccc1Cl>>COc1cc2ccnc(C=Cc3c(Cl)cccc3Cl)c2cc1OC,,CCOCC,,CC(=O)OC(C)=O,,val
US20120214837A1,CCCc1nc(O)cc2cc(OC)c(OC)cc12.CCNc1nc2ccc(OC)cc2cc1CCl.CCNc1nc2ccc(OC)cc2cc1CCl.Cl>>CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCC)c2cc(OC)c(OC)cc12.Cl.Cl,,Cc1ccccc1,ClCCl,[Li+].[OH-],,val
US20090325973A1,C[C@H](N)C(N)=O.O=CC(=O)c1ccccc1>>Cc1nc(-c2ccccc2)c[nH]c1=O,,CO,,[Na+].[OH-],,val
US20120329809A1,COC(=O)NCCn1c(-c2ccccc2Cl)nc2c(N3CCN(C)CC3)nc(C)nc21.Cl>>COC(=O)NCCn1c(-c2ccccc2Cl)nc2c(N3CCN(C)CC3)nc(C)nc21.Cl,,CCOCC,,,,val
US05508302,CO.O=C(O)CCC1CCCCCCCCCCC1=O>>COC(=O)CCC1CCCCCCCCCCC1=O,,CCOCC,,O=S(=O)(O)O,,val
US20100240671A1,CC(NC(=O)OC(C)(C)C)c1cccc(Oc2ccc(Cl)cc2C#N)c1.Cl>>CC(N)c1cccc(Oc2ccc(Cl)cc2C#N)c1.Cl,,C1COCCO1,Cl,,,val
US05216026,NS(=O)(=O)C1CCCC1.O=C=Nc1ccc(Cl)c(Cl)c1>>O=C(Nc1ccc(Cl)c(Cl)c1)NS(=O)(=O)C1CCCC1,,CC(C)=O,O,Cl,[Na+].[OH-],val
US20110172442A1,COC(=O)[C@H](Cc1cn(C=O)c2ccccc12)NC(=O)OC(C)(C)C.Cl>>COC(=O)[C@@H](N)Cc1cn(C=O)c2ccccc12.Cl,,ClCCl,,C1COCCO1,,val
US06534496B1,CC(=O)N1CCC(CCC(=O)c2ccc3c(c2)CCN3)CC1.Clc1ccncc1>>CC(=O)N1CCC(CCC(=O)c2ccc3c(c2)CCN3c2ccncc2)CC1,,CCCCO,,Cl,,val
US20100190732A1,C=Cc1c(C)cc2c(c1C)C(=O)C(C)(C(=O)OCC)C2>>C=Cc1c(C)cc2c(c1C)C(O)C(C)(CO)C2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05646289,CCCCOc1nsnc1S(C)(=O)=O.CN1CCC[C@H]1CO>>CCCCOc1nsnc1OC[C@@H]1CCCN1C,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20090143353A1,CI.C[C@H](c1ccccc1)N1C[C@@](C)(NC(=O)OC(C)(C)C)CC1=O>>C[C@H](c1ccccc1)N1C[C@@](C)(N(C)C(=O)OC(C)(C)C)CC1=O,,CN(C)C=O,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20140243353A1,CCc1ccc(CSc2cc(OCOC)c(=O)n(COC)c2)cc1>>CCc1ccc(CSc2c[nH]c(=O)c(O)c2)cc1,,C1COCCO1,,Cl,,val
US20110237579A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NC1CC=C(OS(=O)(=O)C(F)(F)F)CC1.CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)[nH]1>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NC1CC=C(c2ccc(-c3cnc([C@@H]4CCCN4C(=O)OC(C)(C)C)[nH]3)cc2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US04251543,CC(=O)c1ccc(CC=C(C)C)cc1>>CC(C)=CCc1ccc(C(C)O)cc1,,CO,,O,[BH4-].[Na+],val
US20070254880A1,CCNS(=O)(=O)c1ccccc1O.O=C(NCC1(c2ncccc2F)CCNCC1)c1ccc(Cl)cc1Cl>>CCNS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2ncccc2F)CC1,,C1COCCO1,,Cl,,val
US05728875,CN(C)S(=O)(=O)Cl.COc1ccc(CCNC(=O)[C@@H](N)C(C)C)cc1OC>>COc1ccc(CCNC(=O)[C@](N)(C(C)C)S(=O)(=O)N(C)C)cc1OC,,C1COCCO1,,CCN(CC)CC,Cl,val
US04804668,COC1(OC)SC(c2ccncc2)=C(C)NC1=O>>COC(=O)c1nc(C)c(-c2ccncc2)s1,,Cl,,[Na+].[OH-],,val
US20070015759A1,O=[N+]([O-])c1cccc(CCCO)c1>>O=CCCc1cccc([N+](=O)[O-])c1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20060128793A1,COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CC[C@H](O)[C@@]2(C)C[C@H]1OC(C)=O.OCCNCCO>>COCC1OC(=O)C(=CN(CCO)CCO)C2=C(O)C(=O)C3=C(C(OC(C)=O)CC4(C)C(O)CCC34)C21C,,ClCCl,,,,val
US20050267179A1,FC(F)Oc1ccc(C=Cc2nc(CCl)co2)cc1.O=S(CCn1ccnn1)Cc1ccc(O)cc1>>O=S(CCn1ccnn1)Cc1ccc(OCc2coc(/C=C/c3ccc(OC(F)F)cc3)n2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20030114668A1,COc1cccc(CC2CN(C(=O)OCc3ccccc3)CCN2)c1OC.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>COc1cccc(CC2CN(C(=O)OCc3ccccc3)CCN2C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1OC,,ClCCl,O,CCN(CC)CC,O=C([O-])O.[Na+],val
US20140274696A1,C=C[Sn](CCCC)(CCCC)CCCC.COC(=O)c1nc(-c2ccc(Cl)c(F)c2)c(F)c(NC(=O)OC(C)(C)C)c1Cl>>C=Cc1c(C(=O)OC)nc(-c2ccc(Cl)c(F)c2)c(F)c1NC(=O)OC(C)(C)C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,ClCCCl,,,,val
US20080009530A1,COCCl.O=Cc1ccc(OCCCO)cc1O>>COCOc1cc(OCCCO)ccc1C=O,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070135461A1,C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C(CC#N)=C4CCCC4)c3)ncnc21>>N#CCC(=C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20150175599A1,CCOC(=O)Cl.Nc1cccnc1Cl>>CCOC(=O)Nc1cccnc1Cl,,C1COCCO1,O,[Na+].[OH-],,val
US20070078122A1,CN(C)S(N)(=O)=O.O=C(O)c1ccc2cc3n(c2c1)CC=Cc1ccccc1-3>>NC(=O)c1ccc2cc3n(c2c1)CC=Cc1ccccc1-3,CN(C)c1ccncc1,CC(=O)N(C)C,,CCN=C=NCCCN(C)C,Cl,val
US20120020884A1,CCNCC.CCOC(=O)C1CC(C)CCC1=O>>CCN(CC)C(=O)C1CC(C)CCC1=O,CN(C)c1ccncc1,Cc1ccccc1,,,,val
US20020147198A1,CC(C)(C)OC(=O)N1CCC(CN2CC(C)(C)c3ccc([N+](=O)[O-])cc32)CC1>>CC1(C)CN(CC2CCNCC2)c2cc([N+](=O)[O-])ccc21,,CCOC(C)=O,Cl,,,val
US06613245B1,C=CC(=O)OCCCCO.O=C(O)c1ccc(-c2ccc(O)cc2)cc1>>C=CC(=O)CCCCOC(=O)c1ccc(-c2ccc(O)cc2)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150166564A1,O=[N+]([O-])[C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccccc1>>N[C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccccc1,[Zn],CCO,,Cl,[NH4+].[OH-],val
US05545750,COCCl.OC(CCc1ccccc1)CCc1ccccc1>>COCOC(CCc1ccccc1)CCc1ccccc1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20110251190A1,NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2=CCOCC2)nc1F>>NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2CCOCC2)nc1F,[Pd],,,,,val
US20040116455A1,COc1ccccc1-c1ccc2c(c1)C(CBr)=CC(C)(C)N2.[N-]=[N+]=[N-]>>COc1ccccc1-c1ccc2c(c1)C(CN=[N+]=[N-])=CC(C)(C)N2,,CCOC(C)=O,O,CN(C)C=O,,val
US20100099684A1,Nc1ncc(Cl)cc1Cl.O=C(N=C=S)c1ccccc1>>O=C(NC(=S)Nc1ncc(Cl)cc1Cl)c1ccccc1,,CC(C)=O,,,,val
US20110046133A1,COC(=O)COc1cc(C)c(-c2nc3ccc(C(=O)Nc4ccc5ccccc5n4)cc3[nH]2)c(C)c1>>Cc1cc(OCC(=O)O)cc(C)c1-c1nc2ccc(C(=O)Nc3ccc4ccccc4n3)cc2[nH]1,,CO,,Cl,[Na+].[OH-],val
US20080275046A1,NC(=S)c1ccc(OCCCCl)cc1.O=C(CCl)CCl>>ClCCCOc1ccc(-c2nc(CCl)cs2)cc1,,CCC#N,,,,val
US20090105253A1,CCCCCN.[N-]=[N+]=Nc1ccc(C(=O)O)cc1>>CCCCCNC(=O)c1ccc(N=[N+]=[N-])cc1,,CC#N,CN(C)C=O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US06114527,COC(=O)c1cncnc1O>>O=C(O)c1cncnc1O,,C1CCOC1,O,[Li]O,,val
US20030176454A1,Cc1ncc(-c2cccc(N)c2)n1C.NCc1ccccn1.S=C(n1ccnc1)n1ccnc1>>Cc1ncc(-c2cccc(NC(=S)NCc3ccccn3)c2)n1C,,CC#N,,,,val
US20120196864A1,CNC1=NC(=O)SC1.COc1c(C=O)cccc1Oc1ccc(C#N)cc1C(F)(F)F>>CNC1=NC(=O)S/C1=C\c1cccc(Oc2ccc(C#N)cc2C(F)(F)F)c1OC,,CCO,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20030166639A1,CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)cc1NC(=O)CC(=O)c1cccc(-c2ccc(C3CC3)nc2)c1>>O=C1CC(c2cccc(-c3ccc(C4CC4)nc3)c2)=Nc2ccc(C(F)(F)F)cc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090131483A1,Cc1c(-c2ccnn2C)cc(C(=O)NCc2cc(CCC(N)=O)no2)c(=O)n1-c1cccc(C(F)(F)F)c1>>Cc1c(-c2ccnn2C)cc(C(=O)NCc2cc(CCC#N)no2)c(=O)n1-c1cccc(C(F)(F)F)c1,,ClCCl,,,,val
US20110224262A1,N#CCCc1cc(-c2ccccc2)n[nH]1.O=C1CCC(=O)N1Br>>N#CCCc1[nH]nc(-c2ccccc2)c1Br,,CO,,,,val
US20060030613A1,CC(C)(C)c1ccc(C(=O)NCCc2ccc(F)cc2)c(Cl)c1>>CC(C)(C)c1ccc(CNCCc2ccc(F)cc2)c(Cl)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20160108039A1,CC(Cl)C(=O)Cl.OCCC(CO)NCc1ccccc1>>CC(Cl)C(=O)N(Cc1ccccc1)C(CO)CCO,,CC(C)O,,CCN(CC)CC,,val
US04107308,CSc1nncc2cncn12.NCc1ccccc1>>c1ccc(CNc2nncc3cncn23)cc1,,Cc1ccccc1,,,,val
US20090069430A1,CCCCCI.COC(=O)c1ccc(OC)cc1O>>CCCCCOc1cc(OC)ccc1C(=O)OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05153203,CCOC(=O)c1cn(C2CC2)c2c(F)c(N3CCOC3)c(F)cc2c1=O>>O=C(O)c1cn(C2CC2)c2c(F)c(N3CCOC3)c(F)cc2c1=O,,CC(=O)O,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US05952504,CCCC(=O)c1c[nH]c2c(OC)nccc2c1=O.CS(=O)(=O)Cl>>CCCC(=O)c1cnc2c(OC)nccc2c1OS(C)(=O)=O,,ClCCl,,CCN(CC)CC,O,val
US05208228,CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O[Si](C)(C)C(C)(C)C)C(OC(C)C)C3)C(C)C(O[Si](C)(C)C(C)(C)C)CC1=O)C(C)CC2OC>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OC(C)C)C3)C(C)C(O[Si](C)(C)C(C)(C)C)CC1=O)C(C)CC2OC,,CC#N,CCOC(C)=O,,,val
US20110112080A1,CC(C)(C)OC(=O)N1[C@@H](CCc2ccc(N)cc2)COC1(C)C.O=C(O)c1ccc(Cl)cn1>>CC(C)(C)OC(=O)N1[C@@H](CCc2ccc(NC(=O)c3ccc(Cl)cn3)cc2)COC1(C)C,,C1CCOC1,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20040254214A1,CCOc1cc([C@@H](CC(=O)O)N2Cc3c(Cl)ccc(NC(=O)C4CC4)c3C2=O)ccc1OC.CNC>>CCOc1cc([C@@H](CC(=O)N(C)C)N2Cc3c(Cl)ccc(NC(=O)C4CC4)c3C2=O)ccc1OC,,C1CCOC1,C1CCOC1,O,O=C(n1ccnc1)n1ccnc1,val
US20080096878A1,CS(=O)c1csc(-n2c(=O)n(C(C(=O)[O-])C(C)(C)C)c3ccccc32)n1>>CS(=O)c1csc(-n2c(=O)n(CC(=O)O)c3ccccc32)n1,,O=C(O)C(F)(F)F,,ClCCl,,val
US20090163490A1,COc1ccc(Br)cc1O.O=C1CCC(=O)N1Cl>>COc1cc(Cl)c(Br)cc1O,,CC#N,,O=C(O)C(F)(F)F,,val
US20110183985A1,Cc1nc2c(Br)c(C)ccc2s1.O=C1CCC(=O)N1Br>>Cc1nc2c(Br)c(CBr)ccc2s1,,ClC(Cl)(Cl)Cl,ClCCl,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US05272147,CCCc1nn(C)c2c(=O)[nH]c(-c3cc(N)ccc3OCC)nc12.CS(=O)(=O)Cl>>CCCc1nn(C)c2c(=O)[nH]c(-c3cc(NS(C)(=O)=O)ccc3OCC)nc12,,c1ccncc1,,,,val
US20080318960A1,CC(=O)c1cccc(Br)c1.NNC(=O)C(NC(=O)c1ccccc1)c1n[nH]c(=O)c2ccccc12>>C/C(=N\NC(=O)C(NC(=O)c1ccccc1)c1n[nH]c(=O)c2ccccc12)c1cccc(Br)c1,,CCO,,CC(=O)O,,val
US20060160857A1,Brc1cccnc1.CCOC(=O)c1nc(CCOC)sc1N>>CCOC(=O)c1nc(CCOC)sc1Nc1cccnc1,,C1CCOC1,C1COCCO1,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20050250760A1,CCN1CCN(C(=O)c2cn(CC3CCCCC3)c3c(O)cccc23)CC1.FCCBr>>CCN1CCN(C(=O)c2cn(CC3CCCCC3)c3c(OCCF)cccc23)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20060223850A1,N#Cc1cncc(Br)c1.NO>>NC(=NO)c1cncc(Br)c1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130053364A1,COC(=O)c1c(CS(=O)(=O)CCO)ccc(Br)c1OC>>C=CS(=O)(=O)Cc1ccc(Br)c(OC)c1C(=O)OC,,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US20120197027A1,CCOC(=O)c1cc(OC)c(OCC2CCN(C)CC2)cc1N.N=CN>>O=c1[nH]cnc2ccccc12,,COCCO,,CC(=O)O,,val
US20140121377A1,CC(=O)c1ccc(-n2ccnn2)nc1.C[Si](C)(C)Br>>O=C(CBr)c1ccc(-n2ccnn2)nc1,,CCN(CC)CC,ClCCl,O,,val
US20110112146A1,COC(=O)CC(=O)c1ccccc1O.O=Cc1ccc(Cl)c(C(F)(F)F)c1>>COC(=O)C1C(=O)c2ccccc2OC1c1ccc(Cl)c(C(F)(F)F)c1,,CC(C)O,O,C1CCNCC1,CC(=O)O,val
US20110092497A1,CC(C)(C)OC(=O)N(c1ccc(N2CCOCC2)cc1)c1ncc(B2OC(C)(C)C(C)(C)O2)n2ccnc12.Cc1cc(Br)cc(O[Si](C)(C)C(C)(C)C)n1>>Cc1cc(-c2cnc(Nc3ccc(N4CCOCC4)cc3)c3nccn23)cc(=O)[nH]1,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20120157471A1,C1CNCCN1.Cn1c(-c2cc(Cl)ncc2Cl)nc2ccccc21>>Cn1c(-c2cc(N3CCNCC3)ncc2Cl)nc2ccccc21,,CS(C)=O,O,[Cs+].[F-],,val
US06340694B1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.CS(=O)(=O)c1ccc(-c2oc3ccccc3c(=O)c2Br)cc1>>CS(=O)(=O)c1ccc(-c2oc3ccccc3c(=O)c2-c2ccccn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,CCOC(C)=O,,,val
US04684639,CC(=O)OC(C)=O.O=C(O)CN(C(=O)OCc1ccccc1)c1cc(O)c(O)cc1Cl>>CC(=O)Oc1cc(Cl)c(N(CC(=O)O)C(=O)OCc2ccccc2)cc1OC(C)=O,,O,,C1CCOC1,O=C([O-])[O-].[Na+].[Na+],val
US20060270637A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCCCCC(=O)O>>CN(CCCCC(=O)O)C(=O)OC(C)(C)C,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20100305096A1,C=CS(C)(=O)=O.CC1(C)CN(C(=O)OC(C)(C)C)CCN1>>CC1(C)CNCCN1CCS(C)(=O)=O,,CO,,,,val
US20070173498A1,CC(=O)Nc1ccc2c(c1)CCC(CCN1CCCC1)=C2.O=C(O)c1ccc(-c2ccccc2)cc1>>O=C(Nc1ccc2c(c1)CCC(CCN1CCCC1)=C2)c1ccc(-c2ccccc2)cc1,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,CCN=C=NCCCN(C)C,Cl,val
US20140080798A1,COC(=O)Cc1ccccc1CCc1nc(Nc2cnn(C3CCN(C(=O)OC(C)(C)C)CC3)c2)ncc1C>>Cc1cnc(Nc2cnn(C3CCN(C(=O)OC(C)(C)C)CC3)c2)nc1CCc1ccccc1CC(=O)O,,C1CCOC1,O,[Li]O,,val
US20110130377A1,N#Cc1c(Cl)nc(SCc2coc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1ccc(OCCO)c(F)c1.NCCO>>N#Cc1c(NCCO)nc(SCc2coc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1ccc(OCCO)c(F)c1,,C1CCOC1,,,,val
US20110207714A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(Cl)cc2C=O)C1.Oc1cc(F)ccc1OCc1cccc(Cl)c1>>CC(C)(C)OC(=O)N1CC(Oc2cc(F)ccc2OCc2cccc(Cl)c2)C1,,CN(C)C=O,O,CCOC(C)=O,[H-].[Na+],val
US05538966,COCCN.N#CCCCBr>>COCCNCCCC#N,,CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06326386B1,CC#N.CC(C)(C)OC(=O)N(CCOc1cc(Cl)cc(C(=O)O)c1)c1ccncc1.CCOC(=O)N1c2ccccc2C=CC1OCC>>CC(C)N(CCOc1ccccn1)C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1,,CC#N,,,,val
US20160264573A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(NCc1ccccc1)[C@@H]1CC[C@@H](NOCc2ccccc2)CN1>>CC(C)(C)OC(=O)N1C[C@H](NOCc2ccccc2)CC[C@H]1C(=O)NCc1ccccc1,,CO,,CCN(CC)CC,,val
US20100216860A1,COc1ccc(Cn2nc(N)c3c(OC)cccc32)cc1F.Cc1ccc(S(=O)(=O)Cl)s1>>COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(C)s3)c3c(OC)cccc32)cc1F,,c1ccncc1,,,,val
US04177287,COc1ccc(C(=O)Cl)cc1OC.ClCC1CNC(c2ccccc2)O1>>COc1ccc(C(=O)NCC(O)CCl)cc1OC,,ClC(Cl)Cl,c1ccncc1,Cl,,val
US06420410B1,CCOC(=O)CCBr.CCOC(=O)Cc1cccc2[nH]c(=O)n(Cc3cc(OC)c(OC)c(OC)c3)c12>>CCOC(=O)CCc1cccc2[nH]c(=O)n(Cc3cc(OC)c(OC)c(OC)c3)c12,,CC(=O)N(C)C,,[H-].[Na+],,val
US20130029987A1,CSc1nc(NC(C)(C)C)ncc1C(N)=O.O=S(=O)(c1ccccc1)N1OC1c1ccccc1>>CS(=O)c1nc(NC(C)(C)C)ncc1C(N)=O,,ClC(Cl)Cl,,CCOC(C)=O,,val
US20090105217A1,NNC(=O)c1ccc(NC(=O)c2ccccc2F)cc1F.S=C=S>>O=C(Nc1ccc(-c2n[nH]c(=S)o2)c(F)c1)c1ccccc1F,,CCO,,[K+].[OH-],,val
US20130102776A1,CCCOc1ccc2c(c1CN1CCN(C(=O)OC(C)(C)C)CC1)O/C(=C\c1n[nH]c3ccccc13)C2=O>>CCCOc1ccc2c(c1CN1CCNCC1)O/C(=C\c1n[nH]c3ccccc13)C2=O,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20080287409A1,C1COCCN1.CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)nc1CBr>>CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)nc1CN1CCOCC1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20140066424A1,CC(=N)N.NNC(=O)c1nc(-c2ccc(OC(F)(F)F)cc2)cs1>>CC(=N)NNC(=O)c1nc(-c2ccc(OC(F)(F)F)cc2)cs1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20100330199A1,CCCC[Sn](CCCC)(CCCC)c1cccnc1.CCOC(=O)c1nc(Br)c2snc(-c3ccccc3)c2c1O>>CCOC(=O)c1nc(-c2cccnc2)c2snc(-c3ccccc3)c2c1O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US20050059662A1,O=P(Cl)(Cl)Cl.O=c1[nH]c2cc([N+](=O)[O-])ccc2c(=O)n1CCc1ccc(Cl)cc1Cl>>O=c1c2ccc([N+](=O)[O-])cc2nc(Cl)n1CCc1ccc(Cl)cc1Cl,,O=P(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20080096921A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cc(Br)ccc1O>>Cc1cc(B2OC(C)(C)C(C)(C)O2)ccc1O,,CN(C)C=O,,CC(=O)[O-].[K+],,val
US20150011527A1,CC(C)(C)OC(=O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.CN>>CNC(=O)[C@@H](CC(=O)OC(C)(C)C)NC(=O)OCC1c2ccccc2-c2ccccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040058903A1,CC(=O)Nc1nc(CCl)cs1.Nc1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1>>CC(=O)Nc1nc(CNc2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)cs1,,CN(C)C=O,,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US05405861,C[C@@H](OC1CCCCO1)C(=O)c1ccc(F)cc1F.C[S+](C)(C)=O>>C[C@@H](OC1CCCCO1)C1(c2ccc(F)cc2F)CO1,,CS(C)=O,,[H-].[Na+],,val
US20070082909A1,COC(=O)c1cccc(OC)c1N.N#C[Cu]>>COC(=O)c1cccc(OC)c1C#N,,ClC(Cl)Cl,O,Cl,O=N[O-].[Na+],val
US20160000929A1,C#CCC(CO)CC#C.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C#CCC(CC#C)COC(=O)Cl,,ClCCl,,c1ccncc1,,val
US20050288293A1,CCOC=C(C(=O)OCC)C(=O)OCC.O=C1CNCCN1Cc1ccccc1>>CCOC(=O)c1cn2c(c1O)C(=O)N(Cc1ccccc1)CC2,,Cc1ccccc1,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US06936602B1,CCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3)cc1.O=CO>>CCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3C=O)cc1,,C1CCOC1,,CC(=O)O,,val
US20050014786A1,O=C(NC1Cc2cc(C(F)(F)F)ccc2N(Cc2ccccc2)C1)OCc1ccccc1>>NC1Cc2cc(C(F)(F)F)ccc2N(Cc2ccccc2)C1,[Pd],C1CCOC1,CO,,,val
US20080305066A1,CCCCCCCC=O.CCOC(=O)CC(=O)c1ccccc1>>CCCCCCCC=C(C(=O)OCC)C(=O)c1ccccc1,,COC(C)(C)C,,C1CCNCC1,,val
US20150197505A1,COC(=O)c1ccc(F)c(C)c1.O=[N+]([O-])O>>COC(=O)c1cc(C)c(F)c([N+](=O)[O-])c1,,O=S(=O)(O)O,,,,val
US04596816,CCOC(C)=O.ICCc1ocnc1-c1ccccc1>>O=C(O)CCc1ocnc1-c1ccccc1,,CS(C)=O,,[Na],,val
US20130203802A1,BrC(Br)(Br)Br.OCc1cccnc1F>>Fc1ncccc1CBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130109661A1,CC(C)(C)OC(=O)N1CCN(CCOS(C)(=O)=O)CC1.CC1CCCN1c1cccc(Nc2cc(-c3cccc(O)c3)nn3ccnc23)n1>>CC1CCCN1c1cccc(Nc2cc(-c3cccc(OCCN4CCN(C(=O)OC(C)(C)C)CC4)c3)nn3ccnc23)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04017620,CCc1cc2c(s1)-n1nc(C(N)=O)nc1C(O)N=C2c1ccccc1Cl.CO>>CCc1cc2c(s1)-n1nc(C(N)=O)nc1C(OC)N=C2c1ccccc1Cl,O=S(=O)(O)O,,,,,val
US20100173886A1,CC(C)CCN.NC(=O)c1ccc(Oc2cnc(C=O)c3ccccc23)nc1>>CC(C)CCNCc1ncc(Oc2ccc(C(N)=O)cn2)c2ccccc12,,CC(Cl)Cl,,CC(=O)O,O=C([O-])O.[Na+],val
US20130005687A1,CSc1nc(Cl)c([N+](=O)[O-])c(Cl)n1>>CSc1nc(Cl)c(N)c(Cl)n1,,CCO,,,,val
US04946843,CCOCCn1c(CN2CCN(Cc3ccccc3)CC2)nc2ncccc21>>CCOCCn1c(CN2CCNCC2)nc2ncccc21,[Pd],CO,,[H][H],,val
US20140275071A1,Cn1c(=O)n(C2CC(OCc3ccccc3)C2)c(=O)c2c1ncn2Cc1ccc(Cl)cc1.O=C1CCC(=O)N1Cl>>Cn1c(=O)n(C2CC(OCc3ccccc3)C2)c(=O)c2c1nc(Cl)n2Cc1ccc(Cl)cc1,,CN(C)C=O,,,,val
US20050070549A1,CC(C)(C)OC(=O)N1CCN(c2ccc(Cl)cc2C#N)CC1>>N#Cc1cc(Cl)ccc1N1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110003786A1,CC(=O)Nc1nc(CCl)cs1.Cc1cc(Br)c(O)cn1>>CC(=O)Nc1nc(COc2cnc(C)cc2Br)cs1,,CN(C)C=O,,[H-].[Na+],,val
US20090264399A1,CCOC(=O)c1cnc2[nH]ccc2c1Cl>>O=C(O)c1cnc2[nH]ccc2c1Cl,,CCO,,Cl,[Na+].[OH-],val
US04372953,Cn1nnnc1S.O=C(CCCCl)Cc1ccccc1>>Cn1nnnc1SCCCC(=O)Cc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090163471A1,CCC(=O)C(F)(F)F.NO>>CC/C(=N\O)C(F)(F)F,,O,,Cl,[Na+].[OH-],val
US20160272592A1,N#Cc1ccc(F)cc1N.O=C1CCC(=O)N1Br>>N#Cc1cc(Br)c(F)cc1N,,CN(C)C=O,,,,val
US20100331315A1,O=C1CSC(=S)N1.O=Cc1ccc(-c2cc(C(=O)O)ccc2Cl)o1>>O=C1NC(=S)SC1=Cc1ccc(-c2cc(C(=O)O)ccc2Cl)o1,,CCO,,C1CCNCC1,,val
US05849911,CC[C@H](C)[C@H](NC(=O)OC)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(N)Cc1ccc(-c2cncs2)cc1.COC(=O)N[C@H](C(=O)O)C(C)C>>CC[C@H](C)[C@H](NC(=O)OC)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2cncs2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)C,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20150232460A1,C=CB1OC(C)(C)C(C)(C)O1.CC(C)(C)OC(=O)N[C@H]1CCC[C@@H]1Nc1ncc(C(F)(F)F)nc1Br>>C=Cc1nc(C(F)(F)F)cnc1N[C@H]1CCC[C@@H]1NC(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20070099962A1,COC(=O)c1ccc(F)cc1C#N>>NCc1cc(F)ccc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080182838A1,O.O=CCc1cn(-c2cnc(N3CCC(Oc4ccccc4C(F)(F)F)CC3)nc2)nn1>>O=C(O)Cc1cn(-c2cnc(N3CCC(Oc4ccccc4C(F)(F)F)CC3)nc2)nn1,,CC(C)=O,O,CC=C(C)C,[Na+].[O-]Cl,val
US20150080412A1,CCOC(=O)Cc1cccc(-c2ccc(CCCc3nn(Cc4ccc(C5CC5)cc4)c(=O)n3CC)cc2)c1>>CCn1c(CCCc2ccc(-c3cccc(CC(=O)O)c3)cc2)nn(Cc2ccc(C3CC3)cc2)c1=O,,C1CCOC1,CO,O,[Li+].[OH-],val
US04772600,CCCNCCC.O=C(O)Cn1c(-c2cccc(Br)c2)nc2cccnc21>>CCCN(CCC)C(=O)Cn1c(-c2cccc(Br)c2)nc2cccnc21,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20110028520A1,CC(=O)NC(C)(C)c1cccc(C(F)(F)F)n1>>CC(C)(N)c1cccc(C(F)(F)F)n1,,O,,Cl,[Na+].[OH-],val
US20100273764A1,COc1ccc(Nc2ncc(CN3CCN(C(=O)OC(C)(C)C)CC3)cc2-c2nc(C)nc3c2ncn3C2CCCCO2)cn1>>COc1ccc(Nc2ncc(CN3CCNCC3)cc2-c2nc(C)nc3[nH]cnc23)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090325953A1,O=C(Cl)c1c(F)cc(F)cc1F.O=C(O)c1ccc[nH]1>>O=C(O)c1cc(C(=O)c2c(F)cc(F)cc2F)c[nH]1,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20040229876A1,COc1cc2nccc(Oc3ccc(N)c(F)c3)c2cc1OC.Cc1cc(N)no1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(F)c3)c2cc1OC,,ClC(Cl)Cl,O,CCN(CC)CC,,val
US20160068550A1,Cc1cn(-c2ccnc(N)c2[N+](=O)[O-])cn1>>Cc1cn(-c2ccnc(N)c2N)cn1,[Pd],CO,,ClCCl,,val
US20150152052A1,COC(=O)c1ccc(NC(CCC(F)(F)F)c2ccc(C(=O)NCC(O)C(C)(C)C)cc2C)cc1>>COC(=O)c1ccc(NC(CCC(F)(F)F)c2ccc(C(=O)NCC(=O)C(C)(C)C)cc2C)cc1,,CCOC(C)=O,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20050256316A1,COC(=O)CBr.O=C(NCCCCc1ccccc1)C(Cc1cc(Cl)c(O)c2[nH]ncc12)NS(=O)(=O)c1ccccc1>>O=C(O)COc1c(Cl)cc(CC(NS(=O)(=O)c2ccccc2)C(=O)NCCCCc2ccccc2)c2cn[nH]c12,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20160081334A1,COC1=C(c2c(C)cc(B3OC(C)(C)C(C)(C)O3)cc2C)C(=O)CC1CC#N.O=C(Oc1c(F)c(F)c(F)c(F)c1F)c1ccccn1>>COC1=C(c2c(C)cc(B3OC(C)(C)C(C)(C)O3)cc2C)C(=O)CC1CCNC(=O)c1ccccn1,[Ni],COCCOC,,[H][H],,val
US03931181,CCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1C(=O)CS(C)(=O)=O>>CCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1C(O)CS(C)(=O)=O,,O,,CCO,[BH4-].[Na+],val
US20060287342A1,Clc1ccc(-c2cnc(Cl)nc2-c2ccncc2)cc1.NN>>NNc1ncc(-c2ccc(Cl)cc2)c(-c2ccncc2)n1,,c1ccncc1,,O,,val
US20060235015A1,NCc1ccccn1.O=C1OC(=O)C(c2ccccc2)=C1Cl>>O=C1C(Cl)=C(c2ccccc2)C(=O)N1Cc1ccccn1,,CC(=O)O,,,,val
US20060155128A1,COCCNc1ccc([N+](=O)[O-])c(C)n1>>COCCNc1ccc(N)c(C)n1,[Zn],CC(=O)O,,,,val
US20130150340A1,CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)c2cc(-c3ccc(O)cc3)nc3[nH]ncc23)C1>>N[C@@H]1CCN(C(=O)c2cc(-c3ccc(O)cc3)nc3[nH]ncc23)C1,,C1COCCO1,Cl,O,,val
US20140357612A1,CCN(C)S(=O)(=O)Nc1cccc(C(=O)c2cn(S(=O)(=O)c3ccc(C)cc3)c3ncnc(C)c23)c1F>>CCN(C)S(=O)(=O)Nc1cccc(C(=O)c2c[nH]c3ncnc(C)c23)c1F,,CO,,[K+].[OH-],,val
US20090286790A1,CCC1CC(NC2CCCCC2)CCN1C(=O)OC(C)(C)C.FC(F)(F)c1cc(CBr)cc(C(F)(F)F)c1>>CCC1CC(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCCCC2)CCN1C(=O)OC(C)(C)C,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20060142263A1,O=S1(=O)CCCCN1.O=[N+]([O-])c1ccc(F)cc1>>O=[N+]([O-])c1ccc(N2CCCCS2(=O)=O)cc1,,CN(C)C=O,,[H-].[Na+],,val
US04111940,CCn1ncc2c(Cl)c3c(nc21)C(=O)c1ccccc1CC3.CN1CCC(Cl)CC1>>CCn1ncc2c(Cl)c3c(nc21)C(O)(C1CCN(C)CC1)c1ccccc1CC3,,C1CCOC1,,[Mg],,val
US20130059834A1,COc1ccc2cnn(-c3cnc4c(n3)c(C(=O)NC(C)(C)C)cn4COCC[Si](C)(C)C)c2c1>>COc1ccc2cnn(-c3cnc4[nH]cc(C(=O)NC(C)(C)C)c4n3)c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06245761B1,CCCCCCO.Fc1ccc(Br)cc1CBr>>CCCCCCOCc1cc(Br)ccc1F,,CN(C)C=O,,[H-].[Na+],,val
US20090298807A1,CC(C)(C)OC(=O)N1CC(C)(C)OC2(CCN(Cc3cccc(CCO)c3)CC2)C1>>CC1(C)CNCC2(CCN(Cc3cccc(CCO)c3)CC2)O1,,ClCCl,,Cc1ccccc1,O=C(O)C(F)(F)F,val
US20070203156A1,CC(=O)Oc1ccc(-c2cnc(C(CCCCCCc3ccccc3)O[Si](C)(C)C(C)(C)C)o2)cc1>>O=C(CCCCCCc1ccccc1)c1ncc(-c2ccc(O)cc2)o1,,CCOC(C)=O,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080292626A1,CC(=O)n1ccc2cc3c(=O)oc(CC(C)C)nc3cc21.NCc1cccs1>>CC(C)Cc1nc2cc3[nH]ccc3cc2c(=O)n1Cc1cccs1,,Cc1ccccc1,,[Na+].[OH-],,val
US20140243336A1,O=C(NCC(O)C(F)F)OCc1ccccc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C(NCC(OS(=O)(=O)C(F)(F)F)C(F)F)OCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20070185184A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.NC(=O)c1ccc(-n2c3c(c4ccccc42)C(=O)CCC3)c(Br)c1>>NC(=S)c1ccc(-n2c3c(c4ccccc42)C(=O)CCC3)c(Br)c1,,CCOC(C)=O,,Cc1ccccc1,,val
US20090270430A1,CCNc1nc(C)c2cc(Br)c(=O)[nH]c2n1.OCCCBr>>CCNc1nc(C)c2cc(Br)c(=O)n(CCCO)c2n1,,CN(C)C=O,,[H-].[Na+],,val
US20120277423A1,C=CC(=O)Cl.Cc1ccccc1C>>C=CC(=O)c1ccc(C)c(C)c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080051418A1,CC(C)Oc1ccc(C=O)c(Oc2ccc(Cl)cc2Cl)n1.CCOC(=O)CP(=O)(OCC)OCC>>CCOC(=O)/C=C/c1ccc(OC(C)C)nc1Oc1ccc(Cl)cc1Cl,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US05637729,CC(N=C=S)c1ccccc1.S=C=Nc1ccccc1>>CC1(c2ccccc2)NC(=S)N(c2ccccc2)C1=S,,C1CCOC1,O,Cl,CC(C)(C)[O-].[K+],val
US20060223826A1,C[C@@H](c1c[nH]c2ccccc12)[C@@H](N)C(=O)Nc1cccc(CN(C)C)c1.O=CC1CCC(c2ccccc2)CC1>>C[C@@H](c1c[nH]c2ccccc12)[C@@H](NCC1CCC(c2ccccc2)CC1)C(=O)Nc1cccc(CN(C)C)c1,,CCO,,O=C([O-])O.[Na+],,val
US20140275528A1,Cn1c(=O)c2c(nc(Cl)n2Cc2ccc(Cl)cc2)n(C)c1=O.OCc1cccc(OC(F)(F)F)c1>>Cn1c(=O)c2c(nc(OCc3cccc(OC(F)(F)F)c3)n2Cc2ccc(Cl)cc2)n(C)c1=O,,C1CCOC1,O,[H-].[Na+],,val
US04579862,COc1ccc(COCC(Cn2ccnc2)OCCCCCC(=O)O)cc1.N>>COc1ccc(COCC(Cn2ccnc2)OCCCCCC(N)=O)cc1,,ClCCl,,CCN(CC)CC,CCOC(=O)Cl,val
US20090118305A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1cccc2oc(-c3cc(Br)cnc3N)nc12>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ncc(Br)cc1-c1nc2c(C#N)cccc2o1,CN(C)c1ccncc1,CN(C)C=O,,,,val
US04410520,CCOC(=O)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CC(=O)C2CCCCC21>>CCOC(=O)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CC(O)C2CCCCC21,,CCO,,[BH4-].[Na+],,val
US06133258,Cc1ccc(NC(=S)NC(=O)c2cccnc2Cl)cc1>>Cc1ccc(Nc2nc(=O)c3cccnc3s2)cc1,,O,,Cc1ccccc1,,val
US05677464,CS(=O)(=O)Cl.C[C@@H](n1ccn(-c2ccc(OCC(F)(F)C(F)F)cc2)c1=O)[C@](O)(CO)c1ccccc1F>>C[C@@H](n1ccn(-c2ccc(OCC(F)(F)C(F)F)cc2)c1=O)[C@](O)(COS(C)(=O)=O)c1ccccc1F,,CCOC(C)=O,,CCN(CC)CC,,val
US20160168101A1,Cc1c(-c2ccnn2-c2ccc(C#N)cc2)n(CC(=O)OC(C)(C)C)c(=O)n1-c1cccc(C(F)(F)F)c1>>Cc1c(-c2ccnn2-c2ccc(C#N)cc2)n(CC(=O)O)c(=O)n1-c1cccc(C(F)(F)F)c1,,ClCCl,O,O=C(O)C(F)(F)F,,val
US20060235030A1,CSc1nc(-c2cc(C(=O)O)ccc2C)c2c(n1)N(c1c(F)cccc1F)C(=O)NC2.NCC1CC1>>CSc1nc(-c2cc(C(=O)NCC3CC3)ccc2C)c2c(n1)N(c1c(F)cccc1F)C(=O)NC2,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US20120083469A1,C=CCCC(CCCCB1OC(C)(C)C(C)(C)O1)(C(=O)OC(C)(C)C)N(C)C(=O)OC(C)(C)C.O=[O+][O-]>>CN(C(=O)OC(C)(C)C)C(CCC=O)(CCCCB1OC(C)(C)C(C)(C)O1)C(=O)OC(C)(C)C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20110152237A1,C1N2CN3CN1CN(C2)C3.O=C(CBr)c1ccc(Br)cc1>>NCC(=O)c1ccc(Br)cc1,,CCO,Cc1ccccc1,Cl,,val
US20100286225A1,COC(=O)c1ccccc1CN(C(=O)OC(C)(C)C)S(=O)(=O)c1cc(C(=O)NN2c3ccccc3CC2C)ccc1Cl>>CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(S(=O)(=O)N(Cc2ccccc2C(=O)O)C(=O)OC(C)(C)C)c1,,CC#N,O,[Li+].[OH-],,val
US20040186290A1,Brc1ccc(Br)nc1.ClSC1CC1>>Brc1ccc(SC2CC2)nc1,,Cc1ccccc1,,[Li]CCCC,,val
US20060100229A1,CCCCc1cc(C(N)=O)nn1C(C)(C)C>>CCCCc1cc(C#N)nn1C(C)(C)C,,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20020128434A1,COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O>>CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O,,CO,,[Na+].[OH-],,val
US20050070712A1,CCCc1nc(N)nc(N)c1-c1ccc(N)cc1.O=Cc1ccc(Cl)cc1>>CCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20130066055A1,CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](COCc1ccccc1)Cc1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OC(C)(C)C)C(C)C.O=C(O)C(F)(F)F>>CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](COCc1ccccc1)Cc1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20100317582A1,CCCN.C[C@@H](NC1CC(C(=O)O)C1)c1cccc2ccccc12>>CCCNC(=O)C1CC(N[C@H](C)c2cccc3ccccc23)C1,,CO,ClCCl,,,val
US20090286768A1,COc1cccc(F)c1B(O)O.Oc1ccc(Br)cc1>>COc1cccc(F)c1Oc1ccc(Br)cc1,,ClCCl,,,,val
US20150335632A1,CC(=O)Nc1cc(Cl)c2onc(C3CC3)c2c1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(=O)N(C(=O)OC(C)(C)C)c1cc(Cl)c2onc(C3CC3)c2c1,CN(C)c1ccncc1,ClCCl,,,,val
US05270464,O=C(O)c1cccc([N+](=O)[O-])c1Br.O=S(Cl)Cl>>O=C(Cl)c1cccc([N+](=O)[O-])c1Br,,Cc1ccccc1,,C,,val
US20040023999A1,COC(=O)C(C#N)=C(C)c1ccc(F)cc1OC.[Li]C>>COC(=O)C(C#N)C(C)(C)c1ccc(F)cc1OC,[Cu]I,CCOCC,CCOCC,,,val
US20020045618A1,C=O.c1cncc(N2CCCNCC2)c1>>CN1CCCN(c2cccnc2)CC1,,O,,O=CO,,val
US20120065196A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C1CCC(C(=O)O)NC1>>COC(=O)C1CCC(C(=O)O)N(C(=O)OC(C)(C)C)C1,,C1COCCO1,O,[Na+].[OH-],,val
US20160052884A1,COc1cn(C(CC2(C)CC2)C(=O)OC(C)(C)C)c(=O)cc1-c1cc(Cl)ccc1C#N>>COc1cn(C(CC2(C)CC2)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N,,ClCCl,,O=C(O)C(F)(F)F,,val
US06121281,CCOC(=O)[C@H]1CN2CC[C@@H]1C2>>O=C(O)[C@H]1CN2CC[C@@H]1C2,,Cl,,,,val
US20120172360A1,O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)Nc1cc(F)ccc1O>>O=c1cc(N2CCOCC2)nc(Cc2nc3cc(F)ccc3o2)[nH]1,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140051692A1,C=CCBr.C=CCN1CCOc2ccc(-c3c([C@H](OC(C)(C)C)C(=O)OC)c(C)nc4cc(-c5cccc(-c6cccc(O)c6)c5)nn34)c(Cl)c21>>C=CCOc1cccc(-c2cccc(-c3cc4nc(C)c([C@H](OC(C)(C)C)C(=O)OC)c(-c5ccc6c(c5Cl)N(CC=C)CCO6)n4n3)c2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20020183320A1,Cc1ccc(C)c(C=O)c1.Nc1nccs1.[C-]#[N+]C1CCCCC1>>Cc1ccc(C)c(-c2nc3sccn3c2NC2CCCCC2)c1,,[O-][Cl+3]([O-])([O-])O,,,,val
US20150141406A1,COc1nccc2c(C3=CCCC3)nn(-c3ccc(S(N)(=O)=O)cc3)c12>>COc1nccc2c(C3CCCC3)nn(-c3ccc(S(N)(=O)=O)cc3)c12,[Pd],CO,,O,,val
US20050026916A1,CC(C)(C)OC(=O)N1C(NCc2ccccc2)=N[C@@H](c2ccccc2)[C@H]1c1ccccc1.Cl>>Cl.c1ccc(CNC2=N[C@@H](c3ccccc3)[C@@H](c3ccccc3)N2)cc1,,CCOC(C)=O,,,,val
US20060111370A1,CC(C)(C)OC(=O)NC(C)(CO)c1cccc(Br)c1.O=S(Cl)Cl>>CC(C)(C)OC(=O)N1S(=O)OCC1(C)c1cccc(Br)c1,,CC#N,,c1ccncc1,,val
US06140330,O=C(C1CCCN1)N1CCCC1>>C1CNC(CN2CCCC2)C1,,C1CCOC1,,[H-].[Na+],,val
US20100216760A1,COC(=O)c1nc(N)sc1C(C)C.O=C(Cl)c1cc(C(F)(F)F)ccc1F>>COC(=O)c1nc(NC(=O)c2cc(C(F)(F)F)ccc2F)sc1C(C)C,,ClCCl,,CCN(CC)CC,,val
US20090221645A1,CCOC(=O)C(Br)C(=O)c1ccc2ccccc2c1.S=C1NCCN1>>Br.CCOC(=O)C1=C(c2ccc3ccccc3c2)N2CCN=C2S1,,CC(=O)O,,CCO,,val
US06884821B1,CCOC(=O)C(C(C)C)P(=O)(CC)CC.COc1ccc(C=O)cc1C(=O)OC(C)(C)C>>CCOC(=O)C(=Cc1ccc(OC)c(C(=O)OC(C)(C)C)c1)OC(C)C,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20140135332A1,CC(=O)OCC(CCc1nc(-c2ccc(C(F)(F)F)cc2)c(Br)o1)COC(C)=O.O=C1CCC(=O)N1Br>>CC(=O)OCC(COC(C)=O)CC(Br)c1nc(-c2ccc(C(F)(F)F)cc2)c(Br)o1,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,O,,val
US20040110767A1,Cc1ccc(S(=O)(=O)Oc2ccc(CN(C(=O)C3CCCCC3)c3ccc(OCCN4CCCC4)cc3)cc2)cc1>>O=C(C1CCCCC1)N(Cc1ccc(O)cc1)c1ccc(OCCN2CCCC2)cc1,,CO,,[Na+].[OH-],,val
US20110190269A1,COc1cc(Nc2nc3c(C4=CCN(C(=O)OC(C)(C)C)CC4)cc(C)cn3n2)ccc1-n1cnc(C)c1.Cl.ClCCl>>COc1cc(Nc2nc3c(C4=CCNCC4)cc(C)cn3n2)ccc1-n1cnc(C)c1.Cl.Cl,,CCOCC,ClCCl,,,val
US20120029190A1,Cc1ccnc(-c2nc3c(o2)CN(C(=O)OCc2ccccc2)CC3)c1>>Cc1ccnc(-c2nc3c(o2)CNCC3)c1,,CC#N,,C[Si](C)(C)I,,val
US05350762,CCOC(=O)C1Cc2[nH]c3ccc(OC)cc3c2C1.CN>>CNC(=O)C1Cc2[nH]c3ccc(OC)cc3c2C1,,CCO,,,,val
US20050032871A1,Cc1ccc(S(=O)(=O)c2c(C)[nH]c(C=O)c2CCC(=O)O)cc1.O=C1Cc2cc(F)ccc2N1>>Cc1ccc(S(=O)(=O)c2c(C)[nH]c(/C=C3\C(=O)Nc4ccc(F)cc43)c2CCC(=O)O)cc1,,CCO,,C1CCNCC1,,val
US20140031355A1,CC(NS(=O)C(C)(C)C)c1ccc2ccccc2c1-c1cc(F)cc(F)c1>>CC(N)c1ccc2ccccc2c1-c1cc(F)cc(F)c1,,C1CCOC1,,Cl,,val
US20060047116A1,N#CC1(CC2OCCO2)CCc2ccccc21>>NCC1(CC2OCCO2)CCc2ccccc21,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150094296A1,CCOC(=O)C1(n2cc([N+](=O)[O-])cn2)CCC1>>O=[N+]([O-])c1cnn(C2(CO)CCC2)c1,,C1CCOC1,,O,[BH4-].[Li+],val
US20100113502A1,CC1CCN(C(=O)c2ccc3c(c2)c2c(n3C(=O)N(C)C)CCN(C(=O)OC(C)(C)C)C2)CC1.O=C(O)C(F)(F)F>>CC1CCN(C(=O)c2ccc3c(c2)c2c(n3C(=O)N(C)C)CCNC2)CC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20130053366A1,CC1(c2cccnc2)CO1.Cc1ccc2[nH]c3c(c2c1)CCN(C)CC3>>Cc1ccc2c(c1)c1c(n2CC(C)(O)c2cccnc2)CCN(C)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20010011094A1,Cc1cc(Br)c(N)c(Br)c1.N#Cc1ccc(Nc2nccc(Cl)n2)cc1>>Cc1cc(Br)c(Nc2ccnc(Nc3ccc(C#N)cc3)n2)c(Br)c1,,C1COCCO1,CCOCC,Cl,,val
US20130158009A1,O=[N+]([O-])c1cc2c(cc1F)SCC2>>Nc1cc2c(cc1F)SCC2,[Fe],C1CCOC1,CCO,[Cl-].[NH4+],,val
US20140187542A1,COc1ccc2ncc(=O)n(C[C@@H]3CO3)c2n1.NC[C@H]1CC(=O)N(c2ccc3c(n2)NC(=O)CO3)C1>>COc1ccc2ncc(=O)n(C[C@@H](O)CNC[C@H]3CC(=O)N(c4ccc5c(n4)NC(=O)CO5)C3)c2n1,,CCO,O,,,val
US20140080788A1,O=C(OC(=O)C(F)(F)F)C(F)(F)F.[O-][n+]1cccc2c(Br)cccc21>>O=c1ccc2c(Br)cccc2[nH]1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20100197668A1,COC(=O)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H]2CN(C3(c4cccc(C(F)(F)F)c4)CC3)C(=O)O2)n2c1CN(C(=O)OC(C)(C)C)CC2>>COC(=O)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H]2CN(C3(c4cccc(C(F)(F)F)c4)CC3)C(=O)O2)n2c1CNCC2,,C1COCCO1,ClCCl,Cl,,val
US20070219230A1,Cc1c(C)n(Cc2ccccc2)c2c(N3CCc4ccccc4C3)nc(C#N)cc12.O>>Cc1c(C)n(Cc2ccccc2)c2c(N3CCc4ccccc4C3)nc(C(N)=O)cc12,,CCO,O,[K+].[OH-],,val
US20030166932A1,C=CCBr.CCOC(=O)c1ccc(Nc2ccc3c(c2)C(C(C)(C)C)=CCC3(C)C)cc1>>C=CCN(c1ccc(C(=O)OCC)cc1)c1ccc2c(c1)C(C(C)(C)C)=CCC2(C)C,,CCOCC,,CC(=O)N(C)C,O=C([O-])[O-].[K+].[K+],val
US20130184257A1,CC(C)(C)OC(=O)N1CCC(NC(=O)C(Br)CCBr)CC1>>CC(C)(C)OC(=O)N1CCC(N2CCC(Br)C2=O)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20120034660A1,CCOC(=O)C[C@@](NC(=O)OC(C)(C)C)(C(N)=O)C(=O)OCC>>CCOC(=O)[C@@]1(NC(=O)OC(C)(C)C)CC(=O)NC1=O,,CC(C)=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US04195093,CCO.CCOC(=O)COc1cccc2ccccc12.O=C([O-])[O-]>>O=C(O)COc1ccc(C(=O)c2ccoc2)c2ccccc12,,CCO,,O,,val
US20020188127A1,CC(C)CNc1c([N+](=O)[O-])c2nnnn2c2ccccc12>>CC(C)CNc1c(N)c2nnnn2c2ccccc12,[Pt],CCO,,,,val
US04794188,CCCCCC(=O)c1cccc(OCc2ccc3ccccc3n2)c1.CI>>CCCCC(C)C(=O)c1cccc(OCc2ccc3ccccc3n2)c1,,C1CCOC1,,[H-].[Na+],,val
US20140171414A1,CN(C)Cc1ccccc1.COC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)c2n[nH]c(=O)n2[C@@H]1c1ccc(C#N)cc1CBr>>COC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)c2n[nH]c(=O)n2[C@@H]1c1ccc(C#N)cc1C[N+](C)(C)Cc1ccccc1.[Br-],,CC#N,Cc1ccccc1,,,val
US20030013881A1,C=C(C)OC.CCCC(=O)N[C@H]1c2ccccc2C[C@H]1O>>CCCC(=O)N1[C@H]2c3ccccc3C[C@H]2OC1(C)C,,ClCCl,,CS(=O)(=O)O,,val
US20080194633A1,CC(C)(CO)C(=O)NCc1ccccc1Cl.CCc1ccc(N=C=O)cc1>>CCc1ccc(NC(=O)OCC(C)(C)C(=O)NCc2ccccc2Cl)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20060160081A1,CCOC(=O)c1cccc(OCC2OCCO2)c1.C[Si](C)(C)N=[N+]=[N-]>>CCOC(=O)c1cccc(OCC(N=[N+]=[N-])OCCO)c1,,CO,,Cl[Sn](Cl)(Cl)Cl,,val
US20110190278A1,CCOC(=O)CCN1C(=O)C(C)(C)Oc2cc(C(F)(F)F)c(C(=O)N(C(C)C)[C@@H]3CCCN(C(=O)OC(C)(C)C)C3)cc21>>CC(C)N(C(=O)c1cc2c(cc1C(F)(F)F)OC(C)(C)C(=O)N2CCC(=O)O)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,CO,[Na+].[OH-],val
US04735959,CC(c1ccccc1N1CCCCC1)C(C(N)=O)c1ccc(C(=O)O)cc1.CO>>COC(=O)c1ccc(C(C(N)=O)C(C)c2ccccc2N2CCCCC2)cc1,,ClCCCl,,O=S(=O)(O)O,,val
US20040092561A1,CN(C)C=O.CN1CCOc2ccccc21>>CN1CCOc2cc(C=O)ccc21,,O,,O=P(Cl)(Cl)Cl,,val
US20140142083A1,COC(=O)c1cc(Cl)cc(N)c1OC.O=C1CCOCC1>>COC(=O)c1cc(Cl)cc(NC2CCOCC2)c1OC,,ClCCCl,O,CC(=O)O,O=C([O-])O.[Na+],val
US20130296377A1,CCOC(=O)CNC(c1nc2cc(C#N)ccc2[nH]1)(c1c(OC)cc(C)c2c1ccn2C(=O)OC(C)(C)C)C(F)(F)F>>COc1cc(C)c2[nH]ccc2c1C(NCC(=O)O)(c1nc2cc(C#N)ccc2[nH]1)C(F)(F)F,,CCO,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110294793A1,Fc1ccc(Br)cc1.O=Cc1cccc(O)c1>>O=Cc1cccc(Oc2ccc(F)cc2)c1,[Cu],c1ccncc1,,O=C([O-])[O-].[K+].[K+],,val
US20090215803A1,CC(=O)c1ccc(OCc2ccccc2)c(C)c1.COCCOc1ccccc1C(=O)OC>>COCCOc1ccccc1C(=O)CC(=O)c1ccc(OCc2ccccc2)c(C)c1,,C1CCOC1,O,Cl,[H-].[Na+],val
US20150232464A1,Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC1(C#N)COC(C)(C)OC1.[N-]=[N+]=[N-].[NH4+]>>Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC1(c2nn[nH]n2)COC(C)(C)OC1,,CN(C)C=O,,[Cl-].[Na+],,val
US04810713,OCCCCl.Oc1cccc2cccnc12>>OCCCOc1cccc2cccnc12,,CS(C)=O,,O,CC(C)(C)[O-].[K+],val
US20070244159A1,COC(=O)C1(c2ccc(N)cc2)CC1.O=C1CCC(=O)N1Br>>COC(=O)C1(c2ccc(N)c(Br)c2)CC1,,CC#N,,O,,val
US20070093501A1,CC(C)(C)[C@@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)N1CCC(N2Cc3cnc(CO[Si](C)(C)C(C)(C)C)n3C2=O)CC1>>CC(C)(C)[C@@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)N1CCC(N2Cc3cnc(CO)n3C2=O)CC1,,C1CCOC1,,CC(=O)O,O,val
US08394902B2,CC(C)(C)N.CC(C)(C)NCc1ccc2ccccc2c1-c1cccc(C=O)n1.[Li]c1ccccc1>>CC(C)(C)NCc1ccc2ccccc2c1-c1cccc(C(NC(C)(C)C)c2ccccc2)n1,,CCOCC,O,C1CCOC1,,val
US20080113946A1,Cc1cc(Nc2nc(S(C)(=O)=O)nc3c2COC3)[nH]n1.O=C(Nc1ccc(S)cc1)C1CC1>>Cc1cc(Nc2nc(Sc3ccc(NC(=O)C4CC4)cc3)nc3c2COC3)[nH]n1,,CC(C)(C)O,,,,val
US20150183801A1,O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(Br)c1.OB(O)c1ccc2ccncc2c1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccc3ccncc3c2)c1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US08987319B2,C[Si](C)(C)OC1(C(F)(F)F)CCCc2c1[nH]c1cc(Cl)c(Cl)c(Cl)c21>>OC1(C(F)(F)F)CCCc2c1[nH]c1cc(Cl)c(Cl)c(Cl)c21,,C1CCOC1,O,[K+].[OH-],,val
US20090203750A1,CCOC(=O)[C@@H]1C[C@H]1c1ccc2ccccc2c1>>O=C(O)[C@@H]1C[C@H]1c1ccc2ccccc2c1,,CO,,O,[K+].[OH-],val
US20120083474A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.FC(F)(F)c1ccc(-c2cc(Cl)ncn2)cc1>>CC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)ncn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US20120108757A1,CCOCC.Cl[Mg]Cc1ccccc1.S=C=S>>S=C(S)CCc1ccccc1,,O,,,,val
US20120220565A1,O=C(O)C1CC(OCc2ccccc2)C1>>OCC1CC(OCc2ccccc2)C1,,C1CCOC1,,O,O=C([O-])O.[Na+],val
US20130231329A1,CC#N.CC(=O)OC(C)=O.CN(C)c1ccncc1.CN1CCC(OC(c2cccc(SCCNC(=N)N)c2)c2nc3ccccc3[nH]2)CC1.Cl.Cl>>CC(=O)NC(=N)NCCSc1cccc(C(OC2CCN(C)CC2)c2nc3ccccc3[nH]2)c1.CO.ClCCl.N,CN(C)c1ccncc1,CC#N,,,,val
US20060046999A1,C#CC(=O)OC.N=C(CC(=O)c1ccc(F)cc1)Nc1c(F)cccc1F>>Nc1c(C(=O)c2ccc(F)cc2)ccc(=O)n1-c1c(F)cccc1F,,CO,,,,val
US20160235734A1,COc1ccc(C(O)(C(=O)O)c2cccc(OCCCCC3OCCO3)c2)cc1.O[C@@H]1CC2CCN1CC2>>COc1ccc(C(O)(C(=O)O[C@H]2CN3CCC2CC3)c2cccc(OCCCCC3OCCO3)c2)cc1,,C1CCOC1,CCOC(C)=O,O=C(n1ccnc1)n1ccnc1,,val
US20120095064A1,CCOC(=O)C(C)(C)C#N.OP(=S)(Sc1ccccc1)c1ccccc1>>CCOC(=O)C(C)(C)C(N)=S,,CC(C)O,,,,val
US20130225561A1,COc1cc(C#N)ccc1CC=O.O=[N+]([O-])c1ccc(CCN2CCNCC2)cc1>>COc1cc(C#N)ccc1CCN1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040082780A1,CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4NCC4CCN(C(=O)OC(C)(C)C)CC4)ncn3)cccc2s1>>CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4NCC4CCNCC4)ncn3)cccc2s1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120142705A1,CC(C)CC(C(=O)O)N1C(=O)C(=O)c2cc(Cl)ccc21.Cn1ccc(N)n1>>CC(C)CC(C(=O)Nc1ccn(C)n1)N1C(=O)C(=O)c2cc(Cl)ccc21,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20040067955A1,CC(C)(C)O.CC(C)n1nc(-c2cc(C(=O)O)cnc2-c2ccccc2)ccc1=O.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)n1nc(-c2cc(NC(=O)OC(C)(C)C)cnc2-c2ccccc2)ccc1=O,,CCOC(C)=O,O,CCN(CC)CC,O=C([O-])O.[Na+],val
US04770695,Nc1cc([N+](=O)[O-])c(Cl)cc1F.O=C1OC(=O)C2=C1CCCC2>>O=C1C2=C(CCCC2)C(=O)N1c1cc([N+](=O)[O-])c(Cl)cc1F,,CC(=O)O,,O,,val
US20110053936A1,O=C1Nc2cc(Br)ccc2C1(CCOC1CCCCO1)CCOC1CCCCO1>>O=C1Nc2cc(Br)ccc2C1(CCO)CCO,,C1COCCO1,,Cl,O,val
US20120184542A1,CC(C)(C)OC(=O)NCC(N)C1CCCC1.COc1ncc2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1>>COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CNC(=O)OC(C)(C)C)C4CCCC4)ccc3Cl)c(=O)[nH]c2n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05049669,CCC(C)CNC(=O)c1ccc2c(c1)N(C(C)CN(CC)CC)c1ccccc1S2.O=C(O)/C=C/C(=O)O>>CCC(C)CNC(=O)c1ccc2c(c1)Nc1ccccc1S2.O=C(O)/C=C/C(=O)O,,CC(C)O,,,,val
US20140114040A1,CC(C)(C#N)c1ccc(I)cc1.OB(O)c1ccc(N(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1>>CC(C)(C#N)c1ccc(-c2ccc(N(c3ccc(Cl)cc3)c3ccc(Cl)cc3)cc2)cc1,,CCOC(C)=O,O,C1CCOC1,O=C([O-])[O-].[Na+].[Na+],val
US20060194851A1,CC(=O)c1oc2ccc(Br)cc2c1N.Cc1oncc1C(=O)Cl>>CC(=O)c1oc2ccc(Br)cc2c1NC(=O)c1cnoc1C,,O,,,,val
US20140235863A1,NC(=S)NN=C1CCN(Cc2ccccc2)CC1.O=C(CBr)c1ccc(F)cc1>>Fc1ccc(-c2csc(NN=C3CCN(Cc4ccccc4)CC3)n2)cc1,,C1CCOC1,,,,val
US20080124732A1,CC1=Nc2ncc(Br)cc2C1(C)C.OB(O)c1ccccc1>>CC1=Nc2ncc(-c3ccccc3)cc2C1(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140045746A1,COc1ccc(CN(Cc2ccc(OC)cc2)c2cc(Br)ccn2)cc1.O=C1CCC(=O)N1I>>COc1ccc(CN(Cc2ccc(OC)cc2)c2cc(Br)c(I)cn2)cc1,,CN(C)C=O,,,,val
US20050113387A1,CC(C)n1cc(-c2nc(C(N)=O)c(N)nc2-c2ccc(F)cc2)ccc1=O.[OH-]>>CC(C)n1cc(-c2nc(C(=O)O)c(N)nc2-c2ccc(F)cc2)ccc1=O,,[Na+],[OH-],C1COCCO1,Cl,val
US04900752,CC1(C)Oc2cc3nonc3cc2C(N)C1O.O=C(Cl)CBr>>CC1(C)Oc2cc3nonc3cc2C(NC(=O)CBr)C1O,,ClCCl,,CCN(CC)CC,,val
US04198514,CCOC(=O)CC(C#N)Cc1ccc(F)cc1>>O=C1CC(Cc2ccc(F)cc2)CN1,[Ni],,,,,val
US20120035206A1,O=C1/C(=C/Cl)CSc2sccc21>>O=C1/C(=C\Cl)CSc2sccc21,,CO,,,,val
US20100105655A1,COc1cc(N(C)CCN(C)C(=O)CO)ccc1[N+](=O)[O-]>>COc1cc(N(C)CCN(C)CCO)ccc1[N+](=O)[O-],,C1CCOC1,,,,val
US20050038010A1,COC[C@@H]1CCCN1.Cc1cccc(-c2c(-c3ccnc(Cl)c3)nc(Cl)n(C)c2=O)c1>>COCC1CCCN1c1nc(-c2ccnc(Cl)c2)c(-c2cccc(C)c2)c(=O)n1C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090247746A1,Cc1ccccc1S(=O)(=O)Cl.Nc1cccc2c3c([nH]c12)C(=O)CCC3>>Cc1ccccc1S(=O)(=O)Nc1cccc2c3c([nH]c12)C(=O)CCC3,,c1ccncc1,,,,val
US20130102576A1,COC(=O)CN1C(=O)c2cccc(OC)c2C1=O>>COc1cccc2c1C(=O)N(CC(=O)O)C2=O,,C1COCCO1,,Cl,,val
US20030105132A1,O=C(O)C=Cc1ccc2c(c1)CCC2>>O=C(O)CCc1ccc2c(c1)CCC2,[Pd],CCO,,,,val
US20160200715A1,COC(=O)[C@@]12CC(F)(F)[C@@H](C)[C@H](/C=C/c3ccc(Br)cn3)[C@@H]1[C@@H](C)OC2=O.NN>>C[C@H]1[C@H](/C=C/c2ccc(Br)cn2)[C@@H]2[C@@H](C)OC(=O)[C@]2(C(=O)NN)CC1(F)F,,CCO,CCOC(C)=O,,,val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Nc1ccc2cn[nH]c2c1>>COc1ccc2nc(Nc3ccc4cn[nH]c4c3)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US20030195194A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(Cl)c1cccs1>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cccs2)CC1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20150274704A1,CN(c1nc(Cl)ncc1Cl)C1CCC2(CCCN(C(=O)OC(C)(C)C)C2)C1.Cn1cc(N)cn1>>CN(c1nc(Nc2cnn(C)c2)ncc1Cl)C1CCC2(CCCN(C(=O)OC(C)(C)C)C2)C1,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20090156642A1,Cc1ccc(S(=O)(=O)c2cc(CN(C)C(=O)OC(C)(C)C)nn2-c2ccccc2Cl)nc1.Cl>>CNCc1cc(S(=O)(=O)c2ccc(C)cn2)n(-c2ccccc2Cl)n1.Cl,,CCOC(C)=O,,CCO,,val
US05329052,CC(/C=C\[C@@H]1C[C@H]2C[C@@H]([C@@H]1C)C2(C)C)C1OCCO1>>C/C(C=O)=C\C[C@H]1C[C@H]2C[C@@H]([C@@H]1C)C2(C)C,,C1CCOC1,,Cl,,val
US20030087957A1,CCOc1ccc(C=O)cc1.ONC1CCCCC1>>CCOc1ccc(C=[N+]([O-])C2CCCCC2)cc1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050261291A1,CC(=O)c1ccc(C2CC(C)(C)CC(C)(C)C2)c(N2CCNCC2)c1.CCC=O>>CCCN1CCN(c2cc(C(C)=O)ccc2C2CC(C)(C)CC(C)(C)C2)CC1,,C1CCOC1,CCOCC,O=C([O-])O.[Na+],,val
US20110262352A1,O=C(C1COc2ccccc2O1)N1CCN(c2cccc(Cl)c2Cl)CC1>>Clc1cccc(N2CCN(CC3COc4ccccc4O3)CC2)c1Cl,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20110312963A1,COCC(=O)Nc1cc(Oc2ccc([N+](=O)[O-])c3ccccc23)ncn1>>COCC(=O)Nc1cc(Oc2ccc(N)c3ccccc23)ncn1,[Pt],CO,ClCCl,CC(=O)O,[H][H],val
US20160159838A1,COc1cc(C)cc(-c2cc(C)c(C)cc2O)c1O.ClP(Cl)Oc1c2ccccc2cc2ccccc12>>COc1cc(C)cc2c1op(Oc1c3ccccc3cc3ccccc13)oc1cc(C)c(C)cc12,,Cc1ccccc1,,CCN(CC)CC,,val
US04450166,CCOC(=O)C(=CNc1ccc(CC)cc1)C(=O)[O-]>>CCOC(=O)c1cnc2ccc(CC)cc2c1O,,c1ccc(Oc2ccccc2)cc1,,,,val
US05380724,C1CN(C23CC4CC(CC(C4)C2)C3)CCN1.Nc1cc(Cl)nc(N)n1>>Nc1cc(N2CCN(C34CC5CC(CC(C5)C3)C4)CC2)nc(N)n1,,CCO,,,,val
US20090181928A1,CC(C)(C)OC(=O)[C@H](Cc1ccc(N2CC(=O)N(CC[Si](C)(C)C)S2(=O)=O)c(OCc2ccccc2)c1)NS(=O)(=O)c1ccccc1>>C[Si](C)(C)CCN1C(=O)CN(c2ccc(C[C@H](NS(=O)(=O)c3ccccc3)C(=O)O)cc2OCc2ccccc2)S1(=O)=O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20110081365A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc(C(F)(F)F)ccc1Br>>CC(C)(C)OC(=O)Nc1cc(C(F)(F)F)ccc1Br,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20050191238A1,CC(C)(C)[Si](C)(C)OCCCCc1ccc(CCOc2ncnc3ccccc23)cc1>>OCCCCc1ccc(CCOc2ncnc3ccccc23)cc1,,O,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090247474A1,O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CNCC12CCCO2.O=C1CCC(O)(c2ccccc2)CC1>>O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CN(C2CCC(O)(c3ccccc3)CC2)CC12CCCO2,,C1CCOC1,,CCN(CC)CC,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130237582A1,CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@@H]1CO.Cl>>CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@@H]1CO.Cl,,CC(C)O,,,,val
US20100016386A1,CC(=O)OC[C@H]1OC2SC(NCC(F)(F)F)=NC2[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>OC[C@H]1OC2SC(NCC(F)(F)F)=NC2[C@@H](O)[C@@H]1O,,CO,,O=C([O-])[O-].[K+].[K+],,val
US04219559,Br.C1CO1.Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc32)cc1>>Br.OCCN1CCC(Nc2nc3ccccc3n2Cc2ccc(F)cc2)CC1,,CO,,,,val
US20050143422A1,COC(=O)[C@@H](NS(=O)(=O)c1ccc(-c2ccc(NC(=O)c3oc4cccc(-c5ccoc5)c4c3C)cc2)cc1)C(C)C>>Cc1c(C(=O)Nc2ccc(-c3ccc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)cc3)cc2)oc2cccc(-c3ccoc3)c12,,C1CCOC1,,[Li+].[OH-],,val
US20060293340A1,CN(C)c1cccc(C(=O)O)c1.Cc1ccc(N)cc1Nc1nccc(-c2cnccn2)n1>>Cc1ccc(NC(=O)c2cccc(N(C)C)c2)cc1Nc1nccc(-c2cnccn2)n1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US06420375B1,CCOC(=O)/C=C/c1cnc2ccccc2c1>>OC/C=C/c1cnc2ccccc2c1,,Cc1ccccc1,ClCCl,CC(C)C[Al+]CC(C)C.[H-],,val
US20110263557A1,CI.CS(=O)(=O)N1CCN(Cc2ccc(OC3CCN(c4ncc(-c5nn[nH]n5)cn4)CC3)c(Cl)c2)CC1>>Cn1nnc(-c2cnc(N3CCC(Oc4ccc(CN5CCN(S(C)(=O)=O)CC5)cc4Cl)CC3)nc2)n1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090186831A1,Cc1ccc(S(=O)(=O)O[C@H]2CO[C@@H]3[C@@H](Br)CO[C@H]23)cc1.N>>NC[C@@H](O)[C@@H]1C=CCO1,[Zn],CC(C)O,O,CO,[Cl-].[NH4+],val
US05677464,C[C@H](C(=O)Cl)n1ncn(-c2ccc(OCC(F)(F)C(F)F)cc2)c1=O.Fc1cccc(F)c1>>C[C@H](C(=O)c1ccc(F)cc1F)n1ncn(-c2ccc(OCC(F)(F)C(F)F)cc2)c1=O,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05128351,CCCCCCCCCCCCCCOc1ccc(CC(=O)Nc2ccccc2CBr)cc1.Cc1cncs1>>CCCCCCCCCCCCCCOc1ccc(CC(=O)Nc2ccccc2C[N+]2(C)C=CSC2)cc1.[Br-],,Cc1ccccc1,,CCOCC,,val
US20100298290A1,Cc1nc2ccc(-c3ccc4c(c3)CN(c3ncnc5ccc(OCc6ccccc6)cc35)CCO4)cc2[nH]1>>Cc1nc2ccc(-c3ccc4c(c3)CN(c3ncnc5ccc(O)cc35)CCO4)cc2[nH]1,,O=C(O)C(F)(F)F,,,,val
US20060154929A1,CCOc1ccc(-n2c(C)c(C(C)=O)c(C(C)=O)c2C)c(OC)c1>>COc1cc(O)ccc1-n1c(C)c(C(C)=O)c(C(C)=O)c1C,,ClCCl,,BrB(Br)Br,,val
US06162913,COS(=O)OC.N[C@@H](CCCC1OCCO1)C(=O)O>>COC(=O)[C@@H](N)CCCC(OC)OC,,CO,,C[Si](C)(C)Cl,,val
US20160222005A1,CC(C)(C)OC(=O)N1CCN(Cc2ccc3nc(-c4ccc(OCc5ccccc5)cc4)n(COCC[Si](C)(C)C)c3n2)CC1>>c1ccc(COc2ccc(-c3nc4ccc(CN5CCNCC5)nc4[nH]3)cc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06218431B1,CCCC=Cc1c(C(C)C)nc(C(C)C)c(C(C)O)c1-c1ccccc1OCc1ccccc1>>CCCCCc1c(C(C)C)nc(C(C)C)c(C(C)O)c1-c1ccccc1O,[Pd],CCO,,,,val
US20110269738A1,COC(=O)C1CN(CCc2cc(F)cc(-c3cnc(-c4ccc(OC(C)C)c(Cl)c4)s3)c2OC)C1>>COc1c(CCN2CC(C(=O)O)C2)cc(F)cc1-c1cnc(-c2ccc(OC(C)C)c(Cl)c2)s1,,CC(C)O,O,[Na+].[OH-],,val
US20150025113A1,CCOC(=O)CN1C(=O)C2C3C=C(C(O)(c4ccccc4)c4ccccn4)C(C3=C(c3ccccc3)c3ccccn3)C2C1=O.O=C(CCl)OCC=Cc1ccccc1>>O=C(CN1C(=O)C2C3C=C(C(O)(c4ccccc4)c4ccccn4)C(C3=C(c3ccccc3)c3ccccn3)C2C1=O)OCC=Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090192195A1,C1CCNCC1.O=C(O)c1cccc(S(=O)(=O)Cl)c1>>O=C(O)c1cccc(S(=O)(=O)N2CCCCC2)c1,,ClCCl,,,,val
US20140179667A1,CCOC(=O)c1c(C)c(OS(C)(=O)=O)cc(Br)c1O.Cc1cc(C)c(CN(CCO)C(=O)OC(C)(C)C)c(OCc2ccccc2)n1>>CCOC(=O)c1c(C)c(OS(C)(=O)=O)cc(Br)c1OCCN(Cc1c(C)cc(C)nc1OCc1ccccc1)C(=O)OC(C)(C)C,,C1CCOC1,O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060194783A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1CCNC(c2ccccc2)CN1CC1CC1>>CC(C)(C)OC(=O)N1CCC(=O)N(CC2CC2)CC1c1ccccc1,,ClCCl,O,CCN(CC)CC,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3cc(OC)ncn3)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3cc(OC)ncn3)c2)=C(C)C1=O,,CO,O,O=C([O-])O.[Na+],,val
US20120071489A1,COC(=O)C(=O)N1CCC(COc2ccc(C(=O)N3CCN(c4ccccc4C(C)(C)C)CC3)cc2)CC1>>CC(C)(C)c1ccccc1N1CCN(C(=O)c2ccc(OCC3CCN(C(=O)C(=O)O)CC3)cc2)CC1,,C1CCOC1,CO,[Na+].[OH-],,val
US20070117839A1,COc1cc(/C=C2\CC[C@H]3CCC[C@@H](c4ccc(C(=O)O)cc4)N3C2=O)ccc1-n1cnc(C)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COc1cc(/C=C2\CC[C@H]3CCC[C@@H](c4ccc(N)cc4)N3C2=O)ccc1-n1cnc(C)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20100298302A1,CCOC(=O)c1cccc(-n2cccc2)c1N.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCOC(=O)c1cccc2c1nc(Cl)c1cccn12,,Cc1ccccc1,,,,val
US06350749B1,Cc1ccnc2c1C(=O)CC(c1ccsc1Cl)C2.Cl.N=C(NN)NO>>Cc1ccnc2c1C(=NNC(=N)NO)CC(c1ccsc1Cl)C2.Cl,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20040167183A1,Cc1ccc(S(=O)(=O)Cl)cc1F.NCCc1ccc([N+](=O)[O-])cc1>>Cc1ccc(S(=O)(=O)NCCc2ccc([N+](=O)[O-])cc2)cc1F,,C1CCOC1,,CCN(CC)CC,Cl,val
US20070244153A1,CC(C)OC(=O)N[C@H](C(=O)N[C@H](CN)C(C)C)C(C)C.O=C(Cl)c1cccc2onnc12>>CC(C)OC(=O)N[C@H](C(=O)N[C@H](CNC(=O)c1cccc2onnc12)C(C)C)C(C)C,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US03962325,COS(=O)(=O)OC.O=C(F)C(C(=O)F)C(F)(F)F>>CC(C(=O)F)(C(=O)F)C(F)(F)F,,CCOCC,,CCN(CC)CC,,val
US20130157996A1,CC(C)(C)OC(=O)CBr.O=C(N[C@@H](c1ccc(C(F)(F)F)cc1)c1ncccc1F)c1ccc(O)cn1>>O=C(O)COc1ccc(C(=O)N[C@@H](c2ccc(C(F)(F)F)cc2)c2ncccc2F)nc1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160024110A1,CCOC(=O)CC(=O)CCl.COC(OC)OC>>CCOC(=O)/C=C(\CCl)OC,O=S(=O)(O)O,ClC(Cl)Cl,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20160115128A1,COC(=O)C(C)(C)CO.O=C1NC(=O)c2ccccc21>>COC(=O)C(C)(C)CN1C(=O)c2ccccc2C1=O,,C1CCOC1,Cc1ccccc1,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100063141A1,CI.O=C(c1cc(F)c(O)c(F)c1)c1cc(Br)ccc1Cl>>COc1c(F)cc(C(=O)c2cc(Br)ccc2Cl)cc1F,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140135336A1,CC=O.Cc1nnc2c(NC3CCNCC3)cc(N(C)Cc3ccccc3)nn12>>CCN1CCC(Nc2cc(N(C)Cc3ccccc3)nn3c(C)nnc23)CC1,,C1CCOC1,,CC(=O)O,,val
US20120225884A1,CC(C)(C)C(=O)Nc1ccccn1.CC1(C)CCC(=O)CC1>>CC1(C)CCC(O)(c2cccnc2NC(=O)C(C)(C)C)CC1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20100267709A1,CC(Nc1ncc(C(N)=O)c2[nH]c3cc(C#Cc4cccnc4)ccc3c12)C(C)(C)O>>CC(Nc1ncc(C(N)=O)c2[nH]c3cc(CCc4cccnc4)ccc3c12)C(C)(C)O,[Pd],CCO,,[H][H],,val
US20070265303A1,CC(C)N(CC[C@H](c1ccccc1)c1cc(/C=C/COc2ccc(CCNC(=O)OC(C)(C)C)cc2)ccc1OCc1ccccc1)C(C)C>>CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCOc2ccc(CCNC(=O)OC(C)(C)C)cc2)ccc1O)C(C)C,[Pd],CCO,,[H][H],,val
US20020143035A1,N#Cc1ccc(CN)cc1.O=C1C[C@H]2C(=O)N(c3cc(Cl)cc(Cl)c3)C(=O)N2C1>>N#Cc1ccc(CN[C@H]2C[C@H]3C(=O)N(c4cc(Cl)cc(Cl)c4)C(=O)N3C2)cc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140256933A1,Cc1nc(Cl)nc(C(C)(C)O)c1F.O=C(NC1=N[C@@]2(c3ccns3)CNC[C@H]2CS1)c1ccccc1>>Cc1nc(N2C[C@H]3CSC(NC(=O)c4ccccc4)=N[C@@]3(c3ccns3)C2)nc(C(C)(C)O)c1F,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US05753664,CCCI.O=c1[nH]cnc2[nH]ccc12>>CCCn1cnc2[nH]ccc2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050288273A1,CC(=O)NC[C@H]1CN(c2cc(F)c3c(c2)CCCC(=CN(C)C)C3=O)C(=O)O1>>CC(=O)NC[C@H]1CN(c2cc(F)c3c(c2)CCCC=C3)C(=O)O1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20010003741A1,CCCCCCOCCOCC(=O)O.N[C@@H](CN1CCOCC1)[C@@H](O)c1ccccc1>>CCCCCCOCCOCC(=O)N[C@@H](CN1CCOCC1)[C@@H](O)c1ccccc1,,ClCCl,,ClCCCl,,val
US04940516,CC(=O)OC(C)=O.CCCCCCCCOc1ccc2c(c1)C(=O)c1cc3ccccc3cc1C2=O>>CCCCCCCCOc1ccc2c(OC(C)=O)c3cc4ccccc4cc3c(OC(C)=O)c2c1,[Zn],CCOC(C)=O,,CC(=O)[O-].[K+],,val
US20080051416A1,CC(C)(C)CNC(=O)c1ccc(Br)c(C=O)c1.Cc1c(F)cc(C(=O)NC2CC2)cc1B(O)O>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cc1C=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20160152621A1,CN(Cc1ccccc1)c1ccc2ncc(Br)n2n1.COc1cc([N+](=O)[O-])ccc1B1OC(C)(C)C(C)(C)O1>>COc1cc([N+](=O)[O-])ccc1-c1cnc2ccc(N(C)Cc3ccccc3)nn12,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US05304641,COC(=O)C1=C(CCl)CS[C@@H]2[C@H](NC(=O)c3ccccc3)C(=O)N12>>C=C1CS[C@@H]2[C@H](NC(=O)c3ccccc3)C(=O)N2C1C(=O)OC,,C1CCOC1,,O,,val
US20090286778A1,CC(C)(C)OC(=O)Nc1cncc(CCc2cccc(N)c2)c1.Fc1cnc(Cl)nc1Cl>>CC(C)(C)OC(=O)Nc1cncc(CCc2cccc(Nc3nc(Cl)ncc3F)c2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US07348433B2,COC(=O)/C=C/c1ccc(Sc2ccc(Cl)cc2)cc1>>COC(=O)CCc1ccc(Sc2ccc(Cl)cc2)cc1,[Pd],CCOC(C)=O,,,,val
US20080194587A1,CCOc1cc2c(cc1OC)C(c1ccc(OC)nc1OC)=N[C@@H]1CC[C@@H](O)C[C@H]21.CCS(=O)(=O)O>>CCOc1cc2c(cc1OC)C(c1ccc(OC)nc1OC)=N[C@@H]1CC[C@@H](OS(=O)(=O)CC)C[C@H]21,,CC(=O)CC(C)C,,,,val
US20050228004A1,C#CC(=O)c1c(-c2ccc(F)cc2)nc2c(Cl)cccn12.N=C(N)NC1CCCC1>>Fc1ccc(-c2nc3c(Cl)cccn3c2-c2ccnc(NC3CCCC3)n2)cc1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US05376681,Cc1c(C)c2c(c(C)c1NC=O)CC(C)(CBr)O2.Sc1ccccc1>>Cc1c(C)c2c(c(C)c1NC=O)CC(C)(CSc1ccccc1)O2,,CN(C)C=O,,[H-].[Na+],,val
US20100196502A1,COC(=O)CCCCCCC(=O)Nc1nc(-c2cccc([N+](=O)[O-])c2)cs1>>COC(=O)CCCCCCC(=O)Nc1nc(-c2cccc(N)c2)cs1,[Pd],CC(=O)O,CCO,,,val
US20130225609A1,COC(=O)c1ccc(OC2CCN(c3nc4c(c(NC5CCOCC5)n3)S(=O)CC4)CC2)cc1>>O=C(O)c1ccc(OC2CCN(c3nc4c(c(NC5CCOCC5)n3)S(=O)CC4)CC2)cc1,,CO,,Cl,[Na+].[OH-],val
US20160176891A1,COc1ccc2[nH]ccc2c1.Cc1nc(Cl)c2cc(C)oc2n1>>COc1ccc2c(ccn2-c2nc(C)nc3oc(C)cc23)c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20070225269A1,O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1>>Fc1ccc2[nH]cc(C3CCNC3)c2c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080058335A1,COCCn1c(C)c(C)sc1=N.Cc1ccccc1C(=O)Cl>>COCCn1c(C)c(C)s/c1=N\C(=O)c1ccccc1C,,C1CCOC1,,CCN(CC)CC,,val
US20080171772A1,CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(C3=N[C@@H](COCc4ccccc4)CO3)cc2n1Cc1ccccn1>>CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(C3=N[C@@H](CO)CO3)cc2n1Cc1ccccn1,,ClCCl,,BrB(Br)Br,,val
US20070066624A1,Cc1nc(Br)ccc1C=O.Oc1ccc2c(c1)OCO2>>Cc1nc(Oc2ccc3c(c2)OCO3)ccc1C=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090170908A1,COC(=O)[C@@H]1CC2(CCCCC2)CC[C@H]1OS(C)(=O)=O>>COC(=O)C1=CCCC2(CCCCC2)C1,,C1CCOC1,,C1CCC2=NCCCN2CC1,Cl,val
US04061542,CC(N)(CCCNC(=N)N)C(=O)O.Cl>>CC(N)(CCCNC(=N)N)C(=O)O.Cl,,CC(C)O,,,,val
US20030087926A1,C=Cc1cccc(C)c1.CCC(=O)C(=O)[O-].Nc1cc(Cl)cc(Cl)c1>>Cc1cccc(C2CC(C(=O)O)Nc3cc(Cl)cc(Cl)c32)c1,,CC#N,CCO,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20140378540A1,CC(=O)OC[C@@]12CO[C@@](c3ccc(Cl)c(Cc4ccc(O)cc4)c3)(O1)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]2OC(C)=O.CC(CBr)O[Si](C)(C)C(C)(C)C>>CC(=O)OC[C@@]12CO[C@@](c3ccc(Cl)c(Cc4ccc(OCC(C)O[Si](C)(C)C(C)(C)C)cc4)c3)(O1)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]2OC(C)=O,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080293718A1,C#Cc1cccc(O)c1.COc1cccc(OS(=O)(=O)C(F)(F)F)c1[Si](C)(C)C>>C#Cc1cccc(Oc2cccc(OC)c2)c1,,CC#N,,[Cs+].[F-],,val
US07781443B2,CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(OCCSC)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(OCCS(C)=O)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20060046978A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)CC[C@H](N)C(=O)O>>CCOC(=O)CCC(NC(=O)OC(C)(C)C)C(=O)O,,CO,,CCN(CC)CC,,val
US04195088,CI.O=c1[nH]c2cccnc2n1-c1ccccn1>>Cn1c(=O)n(-c2ccccn2)c2ncccc21,,CO,,[Na+].[OH-],,val
US20140323468A1,Brc1cncc(Br)c1.O=C1CCOCC1>>OC1(c2cncc(Br)c2)CCOCC1,,C1CCOC1,,,,val
US20020120007A1,COc1ccc(NC(=O)c2ccccc2N)cc1.O=C1OC(=O)c2cc3ccccc3cc21>>COc1ccc(NC(=O)c2ccccc2N2C(=O)c3cc4ccccc4cc3C2=O)cc1,,C1CCOC1,,,,val
US20040058907A1,ClCc1ccc(Cl)c(Cl)c1.O=C(NCC1CNCCO1)C(F)(F)F>>O=C(NCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1)C(F)(F)F,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US06174901B1,CCOC(=O)CBr.O=C(Cc1ccncc1)c1ccc(F)cc1>>CCOC(=O)CC(C(=O)c1ccc(F)cc1)c1ccncc1,,CCO,,[Na],,val
US20130196998A1,O=Cc1ccccc1.Oc1ccc2c(c1)OCC21CCNCC1>>Oc1ccc2c(c1)OCC21CCN(Cc2ccccc2)CC1,,ClCCCl,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090197866A1,CN(C)CCNc1cc(N)c([N+](=O)[O-])cc1F>>CN(C)CCNc1cc(N)c(N)cc1F,[Pd],CO,,[H][H],,val
US06255305B1,Cn1nnc(CCl)n1.O=c1[nH]n2c(-c3ccccc3)nnc2cc1-c1ccccc1>>Cn1nnc(COc2nn3c(-c4ccccc4)nnc3cc2-c2ccccc2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20100285544A1,CC(=O)CCc1ccccc1.Cc1ncc(COP(=O)(O)O)c(C=O)c1O>>CC(N)CCc1ccccc1,,O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US04692442,CCOC(O)C(=O)OCc1ccc([N+](=O)[O-])cc1.CO[C@H]1C(=O)N[C@@H]1SC(=S)SCCNC(=O)OCc1ccc([N+](=O)[O-])cc1>>CO[C@H]1C(=O)N(C(O)C(=O)OCc2ccc([N+](=O)[O-])cc2)[C@@H]1SC(=S)SCCNC(=O)OCc1ccc([N+](=O)[O-])cc1,,CN(C)C=O,Cc1ccccc1,,,val
US20110076291A1,Brc1ccc2c(c1)OCCc1sc(-c3nnco3)nc1-2.CC(C)N>>CC(C)n1cnnc1-c1nc2c(s1)CCOc1cc(Br)ccc1-2,,c1ccncc1,,Cl,,val
US20080096860A1,CC(C)OC[C@@H](O)CO[Si](C)(C)C(C)(C)C.Fc1cccc(CSc2nc(Cl)cc(Cl)n2)c1F>>CC(C)OC[C@H](CO[Si](C)(C)C(C)(C)C)Oc1cc(Cl)nc(SCc2cccc(F)c2F)n1,,C1CCOC1,,[H-].[Na+],,val
US20050049236A1,COc1cc(OC)c(CO)cc1C#Cc1ccccc1N>>COc1cc(OC)c(-c2cc3ccccc3[nH]2)cc1CO,Cl[Pd]Cl,CC#N,,,,val
US20080070920A1,Cc1cc(CO)cc(C(C)(C)O[SiH2]C(C)(C)C)c1.[C-]#N>>Cc1cc(CC#N)cc(C(C)(C)O[SiH2]C(C)(C)C)c1,,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US20070021473A1,CCOC(=O)c1ccc(-c2ccc(OCCNC3CC3)c(-c3ccc4c(c3)C(C)(C)CCC4(C)C)c2)cc1>>CC1(C)CCC(C)(C)c2cc(-c3cc(-c4ccc(C(=O)O)cc4)ccc3OCCNC3CC3)ccc21,,C1CCOC1,,[Na+].[OH-],,val
US20100004300A1,COc1ccc(S(=O)(=O)Cl)cc1.O=C1[C@H](O)CCN1c1ccc(S(=O)(=O)Nc2nccs2)cc1>>COc1ccc(S(=O)(=O)N(c2nccs2)S(=O)(=O)c2ccc(N3CC[C@@H](O)C3=O)cc2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110067813A1,CCN(CC)CC.CN(C)C(=O)Cl.NCCCO>>CCN(CC)C(=O)NCCCO,,C1COCCO1,,,,val
US20150266819A1,COc1cc(OC)c(/C=C/S(=O)(=O)Cc2ccc(OC)c(O)c2)c(OC)c1>>COc1cc(OC)c(CCS(=O)(=O)Cc2ccc(OC)c(O)c2)c(OC)c1,[Pd],CO,,[H][H],,val
US20160229814A1,CCn1c(=O)c2cc([N+](=O)[O-])ccc2n(CSC)c1=O>>CCn1c(=O)c2cc(N)ccc2n(CSC)c1=O,,CCO,,Cl[Sn]Cl,,val
US20160002169A1,COc1ccc2c(n1)CCN(C(=O)OC(C)(C)C)C2C(=O)O.C[Si](C)(C)c1c(F)cc(N)cc1F>>COc1ccc2c(n1)CCN(C(=O)OC(C)(C)C)C2C(=O)Nc1cc(F)c([Si](C)(C)C)c(F)c1,CN(C)c1ccncc1,CCOC(C)=O,O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20010020030A1,COC(=O)CS.O=Cc1c(Cl)cncc1Cl.Oc1ccc(Br)cc1>>COC(=O)c1cc2c(Oc3ccc(Br)cc3)cncc2s1,,C1CCOC1,CCOC(C)=O,CC(C)(C)[O-].[K+],,val
US05688815,NC(=O)c1ccc(C(O)c2c(OCc3ccccc3)c(=O)ccn2CCO)cc1>>NC(=O)c1ccc(C(O)c2c(O)c(=O)ccn2CCO)cc1,[Pd],CO,,,,val
US04785103,CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3[C@H](O)[C@@H](Cl)C4=CC(=O)OC[C@]4(C)[C@H]3CC[C@@]21C.CS(=O)(=O)Cl>>CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3[C@H](OS(C)(=O)=O)[C@@H](Cl)C4=CC(=O)OC[C@]4(C)[C@H]3CC[C@@]21C,,O,,c1ccncc1,,val
US20070037829A1,CCCCOC(=O)[C@@H]1CC[C@H](C(=O)O)CC1>>CCCCOC(=O)[C@@H]1CC[C@H](CO)CC1,,C1CCOC1,,B,,val
US05081145,CCC(=O)CC(C)(C)C(=O)OC.COc1ccc(N(N)Cc2ccc([N+](=O)[O-])cc2)cc1>>COc1ccc2c(c1)c(C)c(CC(C)(C)C(=O)O)n2Cc1ccc([N+](=O)[O-])cc1,,CC(C)(C)O,,Cl,,val
US20110112063A1,CNC(=O)CBr.Cc1cc(Nc2nc(Nc3cc(C)c(C4CCCNC4)cc3C)ncc2Cl)n[nH]1>>CNC(=O)CN1CCC[C@@H](c2cc(C)c(Nc3ncc(Cl)c(Nc4cc(C)[nH]n4)n3)cc2C)C1,,CN(C)C=O,,,,val
US20080255111A1,C=O.CC#N.CC(C)(C)OC(=O)c1c(COc2ccc(-c3ccc(CC(=O)O)cc3N)cc2)ccc(C(F)(F)F)c1O>>CN(C)c1cc(CC(=O)O)ccc1-c1ccc(OCc2ccc(C(F)(F)F)c(O)c2C(=O)OC(C)(C)C)cc1,,CC#N,O,CC(=O)O,[BH3-]C#N.[Na+],val
US20100272680A1,C[C@@H]1COC(=O)N1C1CCNCC1.O=C(O)c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1Cl>>C[C@@H]1COC(=O)N1C1CCN(C(=O)c2nc3c(C(F)(F)F)cc(-c4ccoc4)cn3c2Cl)CC1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05563162,COc1cccc2cnc(C)nc12>>Cc1ncc2cccc(O)c2n1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20090042876A1,CCC(=O)[O-].Nc1ccc2[nH]c(=O)c3[nH]ccc3c2c1.O=C(Cl)c1ccccc1>>CCC(=O)[O-].O=C(Nc1ccc2[nH]c(=O)c3[nH]ccc3c2c1)c1ccccc1,,CN(C)C=O,,CCN(CC)CC,,val
US20040229851A1,COCOCCCBr.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COCOCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-],,Cc1ccccc1,,,,val
US20140017797A1,O=C(CCC(Cc1ccccc1)OP(=O)([O-])[O-])Cc1ccccc1>>O=CCCCOP(=O)(O)O,[Pd],CCO,,[H][H],,val
US20140155407A1,CC(O)c1ccc(-c2cccc3ccccc23)nc1.O=C(n1ccnc1)n1ccnc1>>CC(c1ccc(-c2cccc3ccccc23)nc1)n1ccnc1,,CN1CCCC1=O,,,,val
US20140005213A1,CC(c1ccc2nnc(-c3ccc4cccc(C(C)(C)C)c4n3)n2c1)N1CC[C@H](NC(=O)OC(C)(C)C)C1.Cl.ClCCl>>CC(c1ccc2nnc(-c3ccc4cccc(C(C)(C)C)c4n3)n2c1)N1CC[C@H](N)C1.Cl.Cl.Cl,,CC(C)O,ClCCl,,,val
US20010027196A1,CS(=O)(=O)c1nc(N)nc(-c2ccco2)c1C#N.NCCNc1ccccc1>>N#Cc1c(NCCNc2ccccc2)nc(N)nc1-c1ccco1,,COCCOC,,,,val
US20030225142A1,C=CCCCCCCCCO.O=C1CCC(=O)N1Br>>C=CCCCCCCCCBr,,CN(C)C=O,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070259963A1,COC(=O)c1cc(S(C)(=O)=O)c(Oc2ccc([N+](=O)[O-])c(S(F)(F)(F)(F)F)c2)cc1C>>COC(=O)c1cc(S(C)(=O)=O)c(Oc2ccc(N)c(S(F)(F)(F)(F)F)c2)cc1C,[Pd],CC(=O)O,CO,[H][H],,val
US20160194302A1,CCOC(=O)Cn1ccnc1CCC(=O)N1CCC(N(CC)CC)CC1.Cl>>CCOC(=O)Cn1ccnc1CCC(=O)N1CCC(N(CC)CC)CC1.Cl,,CCOCC,,,,val
US20150025095A1,CI.Cc1[nH]c(=S)[nH]c(=O)c1C>>CSc1nc(C)c(C)c(=O)[nH]1,,O,,CC(=O)O,[Na+].[OH-],val
US05229411,CSc1ccc2c3c(cccc13)C(=O)N2.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ccc2c3c(cccc13)C(=O)N2,,CCO,,[Na+].[OH-],,val
US20130281449A1,O=C(O)c1ccc2cc[nH]c2n1.O=C1CCC(=O)N1Cl>>O=C(O)c1ccc2c(Cl)c[nH]c2n1,,CCOC(C)=O,CN(C)C=O,,,val
US20150119380A1,Cc1cnc(N)c(C)n1.O=C(CBr)c1cc2ccc(CCCCO)cc2oc1=O>>Br.Cc1cn2cc(-c3cc4ccc(CCCCO)cc4oc3=O)nc2c(C)n1,,CC#N,,,,val
US20020128321A1,O=[N+]([O-])c1ccc(C(F)(F)F)cc1O>>Nc1ccc(C(F)(F)F)cc1O,,CCO,,Cl[Sn]Cl,,val
US20120041009A1,Cc1c(Cl)ncnc1Cl.OB(O)c1ccccc1>>Cc1c(Cl)ncnc1-c1ccccc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20110053904A1,COc1cc(C(F)(F)F)cc(OCc2ccccc2)c1C(N)=O.O=NOS(=O)(=O)O>>COc1cc(C(F)(F)F)cc(OCc2ccccc2)c1C(=O)O,,ClCCl,O,,,val
US20140088071A1,Fc1ccccc1Cn1nc(-c2ccccn2)nc1Br.c1c[nH]cn1>>Fc1ccccc1Cn1nc(-c2ccccn2)nc1-n1ccnc1,,CN(C)C=O,,[H-].[Na+],,val
US20070173487A1,O=C(O)C1CNC1.O=Cc1ccc(-c2cc3cc(-c4ccccc4)ccc3o2)cc1>>O=C(O)C1CN(Cc2ccc(-c3cc4cc(-c5ccccc5)ccc4o3)cc2)C1,,CO,CS(C)=O,[BH3-]C#N.[Na+],,val
US20070060754A1,CC(C)(C)C(=O)CBr.CCc1nc2cnc3cc(O)ccc3c2n1CCOc1ccccc1>>CCc1nc2cnc3cc(OCC(=O)C(C)(C)C)ccc3c2n1CCOc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030060491A1,CC1(C)CCC(C)(C)c2cc(-c3c[nH]c(C=O)c3)ccc21.CI>>Cn1cc(-c2ccc3c(c2)C(C)(C)CCC3(C)C)cc1C=O,,O,,C1CCOC1,[H-].[Na+],val
US20140088100A1,COc1cc(OC)c(Cl)c(N2Cc3cnc(S(C)(=O)=O)nc3N(C)C2=O)c1Cl.Cc1cccc([N+](=O)[O-])c1N>>COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4c(C)cccc4[N+](=O)[O-])nc3N(C)C2=O)c1Cl,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20130150326A1,COC(=O)c1cccc(Sc2c(C)[nH]c3cc(Cl)ccc23)c1.Ic1ccccc1>>COC(=O)c1cccc(Sc2c(C)n(-c3ccccc3)c3cc(Cl)ccc23)c1,[Cu]I,Cc1ccccc1,,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20130237502A1,CN(C)C.CS(=O)(=O)NCc1ccc(-c2ccc([C@@H](OC(=O)CCCBr)[C@@H](CF)NC(=O)C(F)F)cc2)cn1>>C[N+](C)(C)CCCC(=O)O[C@H](c1ccc(-c2ccc(CNS(C)(=O)=O)nc2)cc1)[C@@H](CF)NC(=O)C(F)F.[Br-],,C1CCOC1,,CCO,,val
US06034246,Nc1ccc(C(=O)O)cc1.Nc1ccccc1S>>Nc1ccc(-c2nc3ccccc3s2)cc1,,O=C([O-])O,[Na+],,,val
US20040229862A1,CC(C)(C)C(=O)Cl.COc1ccc(N2CCOCC2)c2sc(-c3nc4c([nH]3)CCNCC4)nc12>>COc1ccc(N2CCOCC2)c2sc(-c3nc4c([nH]3)CCN(C(=O)C(C)(C)C)CC4)nc12,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20150165026A1,CCOC(=O)COc1ccccc1>>O=C(O)COc1ccccc1,,C1CCOC1,O,CC(=O)O,[Na+].[OH-],val
US20110065702A1,CCOP(=O)(Cc1ccncc1)OCC.N#Cc1ccc2c(C=O)n[nH]c2c1>>N#Cc1ccc2c(/C=C/c3ccncc3)n[nH]c2c1,,CN(C)C=O,,CC(C)(C)O[K],,val
US20070200490A1,Brc1ccc(-n2c(-c3ccccc3)nc3ccccc32)cc1.OB(O)c1ccc2c(-c3ccccc3)c3ccccc3c(-c3ccccc3)c2c1>>c1ccc(-c2c3ccccc3c(-c3ccccc3)c3cc(-c4ccc(-n5c(-c6ccccc6)nc6ccccc65)cc4)ccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20030055248A1,COCCl.Oc1cncc(Cl)c1>>COCOc1cncc(Cl)c1,,C1CCOC1,,[H-].[Na+],,val
US20150376130A1,Nc1ccc(Cl)cc1.O=C(O)c1cnccc1Cl>>O=C(O)c1cnccc1Nc1ccc(Cl)cc1,,CC#N,,,,val
US20150087663A1,CC[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cc1ccccc1NC(=O)c1c(N)cccc1Cl>>CC[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1cccc(Cl)c1C(=O)Nc1ccccc1C,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110071170A1,CNC(=O)Cc1cc2nn(Cc3ncc(C)c(OC)c3Cl)nc3c-2c1CSN=C3N.CS(=O)(=O)O>>CNC(=O)Cc1cc2nn(Cc3ncc(C)c(OC)c3Cl)nc3c-2c1CSN=C3N.CS(=O)(=O)O,,CC#N,,CCOCC,,val
US20160158207A1,CC(CO)N(C)c1cc(Br)c(C#N)cc1[N+](=O)[O-].O=S(Cl)Cl>>CC(CCl)N(C)c1cc(Br)c(C#N)cc1[N+](=O)[O-],,ClCCl,,c1ccncc1,,val
US20100029722A1,Cc1nc(I)sc1C(=O)NCc1ccccc1.N#C[Cu]>>Cc1nc(C#N)sc1C(=O)NCc1ccccc1,,CN(C)C=O,O,,,val
US20070225363A1,C1CCNCC1.CCC(CCNC(=O)CC#N)NC(=O)CC#N.CCO.O=Cc1ccc(O)c(O)c1>>CCC(CCNC(=O)C(C#N)=Cc1ccc(O)c(O)c1)NC(=O)C(C#N)=Cc1ccc(O)c(O)c1,C1CCNCC1,CCO,,,,val
US20100010053A1,CC(C)Oc1ccc(C(=O)O)cc1Cl.CCOC(=O)c1cc2cc(C(=N)NO)ccc2[nH]1>>CCOC(=O)c1cc2cc(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)ccc2[nH]1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US04925838,CS(=O)(=O)O[C@@H]1C[C@@H](C(=O)N2CCNC2=O)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1>>CS(=O)(=O)O[C@H]1CN[C@H](C(=O)N2CCNC2=O)C1,[Pd],C1CCOC1,,CO,[H][H],val
US04940713,C=O.COC(=O)CC[C@H](NC(=O)c1ccc(NCCCc2c(NC(C)=O)nc(NC(C)=O)[nH]c2=O)cc1)C(=O)OC>>CN(CCCc1c(N)nc(N)[nH]c1=O)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1,,CC#N,CN(C)C=O,CC(=O)O,[BH3-]C#N.[Na+],val
US20130211092A1,CCc1ccc(/C(CBr)=N/OC)nc1.O=C1NC(=O)C(Cc2ccc(O)cc2)S1>>CCc1ccc(C(COc2ccc(CC3SC(=O)NC3=O)cc2)=NOC)nc1,,CS(C)=O,,Cl,CC(C)(C)[O-].[K+],val
US20130129677A1,Nc1c(C(=O)Nc2nnc(-c3ccccc3)s2)sc2nc3c(cc12)CCCCC3.O=C(OC(=O)c1ccccc1)c1ccccc1>>O=C(Nc1c(C(=O)Nc2nnc(-c3ccccc3)s2)sc2nc3c(cc12)CCCCC3)c1ccccc1,,CN(C)C=O,,ClCCl,c1ccncc1,val
US20140309225A1,COC(=O)c1cc([N+](=O)[O-])cc(F)c1F.NN>>O=[N+]([O-])c1cc(F)c2[nH]nc(O)c2c1,,CCO,,O,,val
US20050187236A1,CC(C)NC(=O)Oc1ccccc1.CN(C)C=O.Nc1cc(Nc2ccc3[nH]ccc3c2)ncn1>>CC(C)NC(=O)Nc1cc(Nc2ccc3c(ccn3C(=O)NC(C)C)c2)ncn1,,CN(C)C=O,,[H-].[Na+],,val
US05843951,CC1(CCc2cc(O)n3nccc3n2)OCCO1>>CC(=O)CCc1cc(O)n2nccc2n1,,CC(=O)O,O,,,val
US20040110805A1,CC(C)(C)OC(=O)C1(S(=O)(=O)c2ccc(OCCCC(=O)O)cc2)CCOCC1.CCN=C=NCCCN(C)C.Cc1ccccc1C(=O)NN.On1nnc2ccccc21>>Cc1ccccc1-c1nnc(CCCOc2ccc(S(=O)(=O)C3(C(=O)NO)CCOCC3)cc2)o1,,CN(C)C=O,,Cl,O,val
US20080275032A1,CC(C)CCn1nc(-c2cccs2)c(O)c(C2=NS(=O)(=O)c3cc(NS(C)(=O)=O)ccc3N2)c1=O.COCCl>>COCN(c1ccc2c(c1)S(=O)(=O)N=C(c1c(O)c(-c3cccs3)nn(CCC(C)C)c1=O)N2)S(C)(=O)=O,,CN(C)C=O,,[H-].[Na+],,val
US20090221556A1,COc1ccc(CN)cc1.O=[N+]([O-])c1c(Cl)nc2ccccc2c1Cl>>COc1ccc(CNc2c([N+](=O)[O-])c(Cl)nc3ccccc23)cc1,,CN(C)C=O,,CCN(CC)CC,,val
US05990105,CNCCN(C)C.Nc1ccc(S(=O)(=O)c2cc(Br)nc(Br)c2)cc1>>CN(C)CCN(C)c1cc(S(=O)(=O)c2ccc(N)cc2)cc(Br)n1,,C1COCCO1,,,,val
US20110178063A1,CC(C)I.CCOC(=O)c1cn[nH]n1>>CCOC(=O)c1cnnn1C(C)C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04128648,COc1cc(C=C2COCC(=Cc3cc(OC)c(OC)c(OC)c3)C2=O)cc(OC)c1OC.NC1=NCCS1>>COc1cc(C=C2COCC3=C2N=C2SCCN2C3c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC,,ClC(Cl)Cl,,CCO,,val
US05260316,CCOC(=O)Cl.NCCc1cccc(Br)c1>>CCOC(=O)NCCc1cccc(Br)c1,,ClCCl,,CCN(CC)CC,,val
US20110244481A1,CC(C)(C)[Si](C)(C)Oc1ccc(-c2cnc(N)c(-c3cccs3)n2)cc1.CC(C)(C)[Si](C)(C)Oc1ccc(CC(=O)Cl)cc1>>CC(C)(C)[Si](C)(C)Oc1ccc(CC(=O)Nc2ncc(-c3ccc(O[Si](C)(C)C(C)(C)C)cc3)nc2-c2cccs2)cc1,CN(C)c1ccncc1,c1ccncc1,,O,,val
US20100144722A1,COC(=O)C1(c2ccc(Nc3cc(-c4ccccc4)nc(-c4ccc(F)cc4)n3)cc2)CCC1>>O=C(O)C1(c2ccc(Nc3cc(-c4ccccc4)nc(-c4ccc(F)cc4)n3)cc2)CCC1,,O,OCCO,Cl,[Na+].[OH-],val
US20130274255A1,CN1CCN(c2ccc(-c3nn(COCC[Si](C)(C)C)c4c3Cc3sccc3-4)cc2)CC1.O=C1CCC(=O)N1Br>>CN1CCN(c2ccc(-c3nn(COCC[Si](C)(C)C)c4c3Cc3sc(Br)cc3-4)cc2)CC1,,ClCCl,,,,val
US20160115128A1,CI.OC(CN(Cc1ccccc1)Cc1ccccc1)C(F)(F)F>>COC(CN(Cc1ccccc1)Cc1ccccc1)C(F)(F)F,,CN(C)C=O,,O,[H-].[Na+],val
US20020198197A1,Nc1cc(-n2ccc(C=O)c2)ccc1[N+](=O)[O-]>>Nc1cc(-n2ccc(CO)c2)ccc1[N+](=O)[O-],,CCO,,[BH4-].[Na+],,val
US04035372,O=[N+]([O-])c1ccc(CCl)cc1.c1ccc(C(c2ccccc2)C2CCNCC2)cc1>>O=[N+]([O-])c1ccc(CN2CCC(C(c3ccccc3)c3ccccc3)CC2)cc1,,CCO,O,O=C([O-])[O-].[Na+].[Na+],,val
US04590201,Cc1cc(CN=[N+]=[N-])cc(C)c1C(=O)c1ccc(Cl)cc1.N#CCC(N)=O>>Cc1cc(Cn2nnc(C(N)=O)c2N)cc(C)c1C(=O)c1ccc(Cl)cc1,,CCO,,CC(=O)O,[Na],val
US06458830B1,C=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(OO)c1cccc(Cl)c1>>FC(F)(F)c1cc(C2CO2)cc(C(F)(F)F)c1,,ClCCl,O,,,val
US20090312381A1,CCOC(=O)C(C)Br.O=c1[nH]cc(-c2ccc(Cl)cc2)n1C1CC1>>CCOC(=O)C(C)n1cc(-c2ccc(Cl)cc2)n(C2CC2)c1=O,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100120846A1,COc1cc(OC(F)(F)F)ccc1C(C)=O>>CC(=O)c1ccc(OC(F)(F)F)cc1O,,ClCCl,,ClB(Cl)Cl,,val
US05932590,CI.COC(=O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OC(C)(C)C>>COC(=O)[C@@H]1Cc2ccc(OC)cc2CN1C(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030220317A1,CCOC(=O)CCBr.COc1cc(Cl)ccc1S>>CCOC(=O)CCSc1ccc(Cl)cc1OC,,CCOC(C)=O,,CCN(CC)CC,O,val
US20130281432A1,Cn1cc(-c2cccc(N3Cc4cc(C(C)(C)C)ccc4C3=O)c2CO)cc(Nc2ccc(C3CN(C(=O)OC(C)(C)C)C3)cn2)c1=O>>Cn1cc(-c2cccc(N3Cc4cc(C(C)(C)C)ccc4C3=O)c2CO)cc(Nc2ccc(C3CNC3)cn2)c1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160108056A1,COc1cccc(-c2cc(NC(=O)c3cc4ccc(NS(C)(=O)=O)cc4[nH]3)cc(-c3ccc(F)cc3F)c2)n1>>CS(=O)(=O)Nc1ccc2cc(C(=O)Nc3cc(-c4cccc(O)n4)cc(-c4ccc(F)cc4F)c3)[nH]c2c1,,ClCCl,,BrB(Br)Br,CO,val
US20050043389A1,CCOC(=O)C(C(=O)OCC)c1ccc(Br)cc1[N+](=O)[O-]>>O=C1Cc2ccc(Br)cc2N1,[Ni],,,,,val
US20040176593A1,Cc1cc(Br)c(NC(=O)CBr)c(Br)n1.OCCN1CCNCC1>>Cc1cc(Br)c(NC(=O)CN2CCN(CCO)CC2)c(Br)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20140142085A1,COc1cc2[nH]cc(CC(=O)O)c2cc1OCc1ccccc1.COc1ccc(-c2cccnc2[C@@H](N)Cc2cc(F)cc(F)c2)cc1>>COc1ccc(-c2cccnc2[C@H](Cc2cc(F)cc(F)c2)NC(=O)Cc2c[nH]c3cc(OC)c(OCc4ccccc4)cc23)cc1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060142265A1,CN.O=Cc1cccc2c1OCCCO2>>CNCc1cccc2c1OCCCO2,,CO,,O,[BH4-].[Na+],val
US04490369,COc1cc2c(cc1OC)CC(=O)N(CCCN(C)CCc1cc(Cl)c(N)c(Cl)c1)C=C2>>COc1cc2c(cc1OC)CC(=O)N(CCCN(C)CCc1cc(Cl)c(N)c(Cl)c1)CC2,[Pd],CC(=O)O,,[H][H],,val
US20030181496A1,CN(C)S(=O)(=O)n1ccnc1.Cc1ccccc1-c1ccc(C=O)cc1>>Cc1ccc(C(O)c2nccn2S(=O)(=O)N(C)C)cc1,,C1CCOC1,,[Li]CCCC,,val
US20130295141A1,O=CO[C@H](CCc1ccccc1)[C@H](CCn1nnc2ccccc2c1=O)C(=O)O>>O=C(O)[C@@H](CCn1nnc2ccccc2c1=O)[C@H](O)CCc1ccccc1,,CO,,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US20080064710A1,CC(=O)Cl.CC(C)(C)OC(=O)N1CC=C(C#C[Si](C)(C)C)CC1>>C[Si](C)(C)C#CC1=CCNCC1.Cl,,CO,,CCOC(C)=O,,val
US20050137263A1,Cc1ccc(N)c(F)c1.O=C(O)c1ccc(F)c(F)c1F>>Cc1ccc(Nc2c(C(=O)O)ccc(F)c2F)c(F)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20030109750A1,CS(=O)(=O)c1ccccc1N.Cl.O=S=O>>CS(=O)(=O)c1ccccc1S(=O)(=O)Cl,Cl[Cu],O,,O=N[O-].[Na+],,val
US20080269196A1,CC(C)(C)N.N#Cc1ccc(CCC(=O)O)cc1>>CC(C)(C)NC(=O)CCc1ccc(C#N)cc1,,Cc1ccccc1,ClCCl,CCN(CC)CC,O=S(Cl)Cl,val
US20100256357A1,CCOC(=O)CC(=O)C(F)(F)F.NNc1ccc(S(N)(=O)=O)cn1>>NS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2O)nc1,,CC(=O)O,O,,,val
US07429565B2,COC(=O)CP(=O)(OCC(F)(F)F)OCC(F)(F)F.COc1c(C)c2c(c(OCC[Si](C)(C)C)c1CC=C(C)CBr)C(=O)OC2>>COC(=O)C(CC(C)=CCc1c(OC)c(C)c2c(c1OCC[Si](C)(C)C)C(=O)OC2)P(=O)(OCC(F)(F)F)OCC(F)(F)F,,C1CCOC1,,CCOC(C)=O,[Cl-].[NH4+],val
US20100093779A1,C=Cc1cc2c(O[C@@H]3C[C@@H](C(=O)OC)N(C(=O)OC(C)(C)C)C3)cc(OCC)nc2cc1OC.Cl.ClCCl>>C=Cc1cc2c(O[C@H]3CN[C@H](C(=O)OC)C3)cc(OCC)nc2cc1OC.Cl.Cl,,ClCCl,,,,val
US04180394,CCNCC.CCOC(=O)CN(CP(=O)(OCl)OCl)C(=O)C(F)(F)F.Sc1ccccc1>>CCOC(=O)CN(C(=O)C(F)(F)F)C(N(CC)CC)P(=O)(O)OSc1ccccc1,,CCOCC,,CCN(CC)CC,,val
US20150361065A1,CC(C)OC(=O)/C=C/c1ccc(Oc2c(-c3ccccc3C(C)C)sc3cc(O[Si](C)(C)C(C)(C)C)ccc23)cc1>>CC(C)OC(=O)/C=C/c1ccc(Oc2c(-c3ccccc3C(C)C)sc3cc(O)ccc23)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080070931A1,COC(=O)c1cnc(Cl)c(Br)c1.OB(O)c1ccc(Cl)cc1>>COC(=O)c1cnc(Cl)c(-c2ccc(Cl)cc2)c1,,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20050009804A1,COC(=O)c1sc(-c2ccccc2)cc1N(C(=O)C1CCC(C)CC1NC(C)=O)C(C)C>>CC(=O)NC1CC(C)CCC1C(=O)N(c1cc(-c2ccccc2)sc1C(=O)O)C(C)C,,C1COCCO1,,O,[Li+].[OH-],val
US20110190351A1,COC(=O)c1ccc(F)c2[nH]c(-c3cccs3)nc12>>O=C(O)c1ccc(F)c2[nH]c(-c3cccs3)nc12,,[Na+],[OH-],,,val
US20140065103A1,CC[C@H](Nc1cc(C#CC(C)(C)C)sc1C(=O)OC)C(=O)OC(C)(C)C.CO>>CC[C@H](Nc1cc(C#CC(C)(C)C)sc1C(=O)OC)C(=O)OC,,CO,,Cl,,val
US20100029633A1,COCCOc1ccn2c(-c3ccc4cccc(O[C@H]5CN(C(=O)OCc6ccccc6)C[C@H]5F)c4n3)cnc2c1.Cl>>COCCOc1ccn2c(-c3ccc4cccc(O[C@@H]5CNC[C@@H]5F)c4n3)cnc2c1.Cl,[Pd],CCO,,,,val
US20130261122A1,O=C(O)c1cnc(Cl)nc1.OB(O)c1ccc2cc(O)ccc2c1>>O=C(O)c1cnc(-c2ccc3cc(O)ccc3c2)nc1,,C1COCCO1,O,,,val
US20040082570A1,CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2c1c(=O)n(CCN=[N+]=[N-])c(=O)n2C>>CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2c1c(=O)n(CCN)c(=O)n2C,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020156094A1,CC(=O)NC(C(=O)OC(C)(C)C)C(C(C)=O)N1CCc2ccccc2C1=O.C[N+](=O)[O-]>>CC(=O)NC(C(=O)OC(C)(C)C)C(C(O)C[N+](=O)[O-])N1CCc2ccccc2C1=O,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20050107334A1,CC(C)(C)C(=O)O.CCSC(=O)OOC(Cl)C(C)C>>CCSC(=O)OOC(OC(=O)C(C)(C)C)C(C)C,,CCOCC,,CCN(C(C)C)C(C)C,O,val
US20120040981A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCc1c(Br)cnn1S(=O)(=O)N(C)C>>CCc1c(B2OC(C)(C)C(C)(C)O2)cnn1S(=O)(=O)N(C)C,,COCCOC,,CC(=O)[O-].[K+],,val
US20060089370A1,O=C1c2ccccc2C(=O)N1CCc1ccc(N2CCOCC2)cc1>>NCCc1ccc(N2CCOCC2)cc1,,CCO,,NN,O,val
US03951980,CCOC(=O)[C@H]1CC[C@@H](C(=O)OCC)N1C.NCc1ccccc1>>CCOC(=O)[C@H]1CC[C@@H](C(=O)NCc2ccccc2)N1C,,Cc1ccccc1C,,,,val
US04515626,ClCCCc1nc(C(Cl)(Cl)Cl)nc(C(Cl)(Cl)Cl)n1.N>>Nc1nc(CCCCl)nc(C(Cl)(Cl)Cl)n1,,C1CCOC1,,O,,val
US20070293515A1,CC(C)(C)OC(=O)N[C@H]1CC[C@H](C(=O)O/N=C(\N)c2ccccc2)C1>>CC(C)(C)OC(=O)N[C@H]1CC[C@H](c2nc(-c3ccccc3)no2)C1,,CCO,O,CC(=O)[O-].[Na+],,val
US20130217709A1,O=[N+]([O-])[C@@H]1CN(Cc2ccccc2)C[C@H]1c1cccc(F)c1>>N[C@@H]1CN(Cc2ccccc2)C[C@H]1c1cccc(F)c1,,CO,,N,,val
US20140179676A1,COC(OC)OC.Cn1nc(C(N)=NO)cc1[N+](=O)[O-]>>Cn1nc(-c2ncon2)cc1[N+](=O)[O-],,CO,,O=C(O)C(F)(F)F,,val
US20080255114A1,CC(C)[C@@H]1COCC(=O)N1>>CC(C)[C@@H]1COCCN1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040082607A1,COc1ccc(-c2c(CN3C(=O)c4ccccc4C3=O)n(C)c(=O)c3ccc(Cl)cc23)cc1>>Cn1c(CN2C(=O)c3ccccc3C2=O)c(-c2ccc(O)cc2)c2cc(Cl)ccc2c1=O,,ClCCl,,BrB(Br)Br,O,val
US20080200525A1,CC(=O)C(=NO)c1ccc(OCCCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)cc1.CI>>CON=C(C(C)=O)c1ccc(OCCCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05389649,O=C(OO)c1cccc(Cl)c1.OCCSCc1cccnc1>>O=S(CCO)Cc1cccnc1,,ClCCl,,,,val
US20040006143A1,CCOC(=O)COc1cccc(COc2ccc(CCN(C[C@H](O)c3cccc(Cl)c3)C(=O)OC(C)(C)C)cc2)c1>>CCOC(=O)COc1cccc(COc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c1,,C1CCOC1,C1COCCO1,Cl,,val
US20100216746A1,COC(=O)c1[nH]c(C(C)=O)cc1Cl>>CC(=O)c1cc(Cl)c(C(=O)O)[nH]1,,C1CCOC1,,CO,[Li+].[OH-],val
US20070154906A1,COC(=O)CCCOc1cc([N+](=O)[O-])c(C(=O)N2CCCC2CO)cc1OC>>COC(=O)CCCOc1cc(N)c(C(=O)N2CCCC2CO)cc1OC,[Pd],CCO,,CCOC(C)=O,[H][H],val
US05591722,Cc1ccccc1C(=O)OC[C@H]1S[C@@H](n2cc(C)c(=O)[nH]c2=O)C[C@@H]1OC(=O)c1ccccc1C>>Cc1cn([C@H]2C[C@H](O)[C@@H](CO)S2)c(=O)[nH]c1=O,,CO,,C[O-].[Na+],,val
US20110263526A1,CC(Cl)OC(=O)Cl.COc1ccc2cc(C(C)C(=O)OCCSCCO)ccc2c1>>COc1ccc2cc([C@H](C)C(=O)OCCSCCOC(=O)OC(C)Cl)ccc2c1,,ClCCl,,c1ccncc1,,val
US20090143367A1,Cc1cn(-c2cc(Cl)ccc2N)c(C2CCCCC2)n1.O=C(n1ccnc1)n1ccnc1>>Cc1nc(C2CCCCC2)n2c1c(=O)[nH]c1ccc(Cl)cc12,,Cc1ccccc1,,O,,val
US20160251380A1,CC1(C)C2CC[C@@]1(C)/C(=N\Cc1ccccn1)C2>>CC1(C)C2CC[C@@]1(C)C(NCc1ccccn1)C2,[Pt],Cc1ccccc1,,[H][H],,val
US05559106,COc1ccc(Cn2c(=O)c(Cl)nc3ccc4ccccc4c32)c(OC)c1.NN>>COc1ccc(Cn2c(=O)c(NN)nc3ccc4ccccc4c32)c(OC)c1,,ClCCl,,O,,val
US20020169188A1,CC(=O)c1cccc(-c2ccc3oc(CCN4CCC[C@H]4C)cc3c2)c1.C[Mg]Br>>C[C@@H]1CCCN1CCc1cc2cc(-c3cccc(C(C)(C)O)c3)ccc2o1,,C1CCOC1,,CCOCC,,val
US20070225352A1,CC(C)[Si](Cl)(C(C)C)C(C)C.O=[N+]([O-])c1ccc2cc[nH]c2c1>>CC(C)[Si](C(C)C)(C(C)C)n1ccc2ccc([N+](=O)[O-])cc21,,C1CCOC1,,[Li]CCCC,,val
US03992535,CCI.O=S1(=O)NCC2(OCCO2)c2ccc3ccccc3c21>>CCN1CC2(OCCO2)c2ccc3ccccc3c2S1(=O)=O,,CC(C)O,,O,[Na+].[OH-],val
US20130029938A1,C=CC(=O)OCC.CCCC[C@]1(CC)CS(=O)(=O)c2cc(OS(=O)(=O)C(F)(F)F)c(OC)cc2[C@@H](c2ccccc2)N1>>CCCC[C@]1(CC)CS(=O)(=O)c2cc(/C=C/C(=O)OCC)c(OC)cc2[C@@H](c2ccccc2)N1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,CCN(CC)CC,,val
US05990107,CC(C)(C)OC(=O)Nc1ccc(O)c([N+](=O)[O-])c1.CCOC(=O)CBr>>CCOC(=O)COc1ccc(NC(=O)OC(C)(C)C)cc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06492355B1,CC(C)(C)OC(=O)N1CCC(=Cc2ccc(Cl)c(C(=O)NCC34CC5CC(CC(C5)C3)C4)c2)CC1.Cl>>Cl.O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(C=C2CCNCC2)ccc1Cl,,C1COCCO1,CO,,,val
US20020045654A1,O=C(CBr)c1ccc(Br)cc1.O=C[O-].[NH4+]>>Brc1ccc(-c2cocn2)cc1,,O=CO,,[Na+].[OH-],,val
US20040077726A1,NO.O=C(Cl)C=Cc1ccc(S(=O)(=O)Nc2ccccc2)cc1>>O=C(C=Cc1ccc(S(=O)(=O)Nc2ccccc2)cc1)NO,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20150266821A1,Cc1ccc(S(=O)(=O)n2c3c(c4cc(Cl)c(Cl)cc42)CCC(F)(F)C3(O[Si](C)(C)C)C(F)(F)F)cc1>>OC1(C(F)(F)F)c2[nH]c3cc(Cl)c(Cl)cc3c2CCC1(F)F,,C1CCOC1,O,CCO,[K+].[OH-],val
US20070244103A1,CI.Cc1cccc2ncc(=O)[nH]c12>>COc1cnc2cccc(C)c2n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150011773A1,CC(C)(C)OC(=O)N[C@@H](C[C@H](Cc1ccc(CCCF)cn1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>N[C@@H](C[C@H](Cc1ccc(CCCF)cn1)C(=O)O)C(=O)O,,O=C(O)C(F)(F)F,,Cc1ccccc1,,val
US04556717,CCCC(C=NNC(=O)OC)c1ccc(Cl)cc1Cl>>CCCC(CNNC(=O)OC)c1ccc(Cl)cc1Cl,[Pt],CC(=O)O,,,,val
US20050124605A1,O=C(O)CBr.OCc1ccccc1>>O=C(O)COCc1ccccc1,,C1CCOC1,,O,[H-].[Na+],val
US20080096903A1,Cc1ccc(S(=O)(=O)OCCCCCCCCO)cc1.Nc1nc(F)nc2[nH]c(Cc3cc4c(cc3I)OCO4)nc12>>Nc1nc(F)nc2c1nc(Cc1cc3c(cc1I)OCO3)n2CCCCCCCCO,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030236296A1,Cc1cccc(C)c1C(=O)OCC(=O)C(CC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1>>Cc1cccc(C)c1C(=O)OCC(=O)C(N)CC(=O)OC(C)(C)C,[Pd],CCO,Cl,,,val
US04968340,COC(=O)C(O)C(C)(C)C.Cc1cc(C)nc(S(C)(=O)=O)n1>>COC(=O)C(Oc1nc(C)cc(C)n1)C(C)(C)C,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05556977,COC(=O)CNC(=O)COc1ccc(C(=O)CBr)cc1.c1cc(N2CCNCC2)ccn1>>COC(=O)CNC(=O)COc1ccc(C(=O)CN2CCN(c3ccncc3)CC2)cc1,,CC#N,,,,val
US04471116,BrCCCBr.Oc1ccc(OCc2ccccc2)cc1>>BrCCCOc1ccc(OCc2ccccc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04038280,C=O.Cc1cc(C2CC(C)(C)NC(C)(C)C2)cc(C)c1O>>Cc1cc(C2CC(C)(C)N(C)C(C)(C)C2)cc(C)c1O,,O=CO,,,,val
US20100105655A1,COC(=O)C1C=C(c2ccc(NC(=O)OC(C)(C)C)c(OC)c2)CN1C(=O)OC(C)(C)C>>COc1cc(C2=CC(C(=O)O)N(C(=O)OC(C)(C)C)C2)ccc1NC(=O)OC(C)(C)C,,CO,,[Na+].[OH-],,val
US20120046419A1,C=CCCCCC=C.C=CCCCCCC.C=Cc1ccccc1>>C=CCCCCC=C.C=CCCCCCC.C=Cc1ccccc1,,Cc1ccccc1,,,,val
US20150087646A1,NC1(c2ccc(C(F)(F)F)cc2)CC1.O=C(O)c1ccc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)cc1>>O=C(NC1(c2ccc(C(F)(F)F)cc2)CC1)c1ccc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20020099068A1,Cl.O=C1CCC(=O)N1Cl.c1ccc2c(c1)[nH]c1cnccc12>>Clc1ccc2c3ccncc3n(Cl)c2c1,,O,,,,val
US20040204406A1,COC(=O)c1cc(C(=O)OC)n(Cc2cc(-c3ccc(Cl)s3)on2)n1>>COC(=O)c1cc(C(=O)O)n(Cc2cc(-c3ccc(Cl)s3)on2)n1,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20030119831A1,CN.O=C=Nc1ccc(Cl)cc1Cl>>CNC(=O)Nc1ccc(Cl)cc1Cl,,C1CCOC1,,CCO,,val
US20130197049A1,COc1cc(C(=O)c2csc(-c3ccccc3)n2)cc(OC)c1OC.NN>>COc1cc(/C(=N/N)c2csc(-c3ccccc3)n2)cc(OC)c1OC,,CCO,ClCCl,O,,val
US20150038438A1,Nc1ccc(Br)c(Cl)c1F.O=C1CCC(=O)N1I>>Nc1c(I)cc(Br)c(Cl)c1F,,CC(=O)O,,,,val
US20130017488A1,CCC12CCC(C=C1c1ccccc1)C2.O=C1C=CC(=O)O1>>CCC12CCC(C=C1c1ccccc1)C2.O=C1C=CC(=O)O1,,C1CCOC1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20110065717A1,CS(=N)(=O)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)cc1.N#CBr>>CS(=O)(=NC#N)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20030225097A1,CC(C)(C)C(=O)Cl.Nc1ccc2sc3ccccc3c2c1>>CC(C)(C)C(=O)Nc1ccc2sc3ccccc3c2c1,,ClCCl,,CCN(CC)CC,,val
US05130328,CC(=O)NCO.CC(=O)OC(C)=O>>CC(=O)NCO.CC(=O)O,c1ccncc1,,,,,val
US06514964B1,O=C(Cc1ccccc1Br)NCc1ccccc1>>Brc1ccccc1CCNCc1ccccc1,,C1CCOC1,,CSC,,val
US05747514,O=C(N[C@@H](Cc1ccccc1)C(=O)Nc1ccccc1)OCc1ccccc1>>N[C@@H](Cc1ccccc1)C(=O)Nc1ccccc1,[Pd],CCO,,C1=CCCCC1,,val
US20140031364A1,COC(=O)CC#N.ON=C(Cl)c1ccccc1C(F)(F)F>>COC(=O)c1c(-c2ccccc2C(F)(F)F)noc1N,,CO,,C[O-].[Na+],,val
US05185351,CCCCc1ncc(/C=C(\Cc2ccncc2)C(=O)OC)n1Cc1ccccc1Cl>>CCCCc1ncc(/C=C(\Cc2ccncc2)C(=O)O)n1Cc1ccccc1Cl,,CCO,,[Na+].[OH-],,val
US20090209524A1,CCCCN.Cc1cc(C)c(S(=O)(=O)Oc2nc(N)nc(C)c2Cc2ccc(CC#N)cc2)c(C)c1>>CCCCNc1nc(N)nc(C)c1Cc1ccc(CC#N)cc1,,C1COCCO1,,,,val
US20080167307A1,CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCNc2ncc(Br)cn2)cs1.O=C(O)C(F)(F)F.OB(O)c1cccs1>>CC(C)(Sc1nc(CCNc2ncc(-c3cccs3)cn2)cs1)C(=O)O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04307113,NC(=O)c1ccc(C(F)(F)F)c(N)c1.O>>Nc1cc(C(=O)O)ccc1C(F)(F)F,,O,,Cl,[Na+].[OH-],val
US20090275578A1,COC(=O)c1c(Cl)cccc1CBr.NCCCc1ccccc1>>O=C1c2c(Cl)cccc2CN1CCCc1ccccc1,,CCCCCC,Cc1ccccc1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20060128715A1,Cn1cc2c(n1)CCC(NC[C@@H](O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)OC(C)(C)C)(c1cccc(I)c1)C2>>Cn1cc2c(n1)CCC(NC[C@@H](O)[C@@H](N)Cc1cc(F)cc(F)c1)(c1cccc(I)c1)C2,,C1COCCO1,,Cl,,val
US20160009711A1,COC(OC)N(C)C.Cc1ccc(-c2nc(N)c(Br)cc2-c2ccc(C#N)cc2)cc1.NO>>Cc1ccc(-c2nc(NC=NO)c(Br)cc2-c2ccc(C#N)cc2)cc1,,CC(C)O,,Cl,,val
US20040077670A1,Cc1ccc(NS(=O)(=O)Nc2ncnc(OCCO)c2-c2ccc(C)cc2)cc1.Clc1ncc(Br)cn1>>Cc1ccc(NS(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20050107364A1,CC(C)CC[C@@](C)(C(=O)N[C@H](CO)c1ccccc1)c1ccccc1.O=S(=O)(O)O>>CC(C)CC[C@@](C)(C(=O)O)c1ccccc1,,C1COCCO1,,,,val
US20100130545A1,CC(C)C(=O)O[C@@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@H]2CC[C@@H]1C=C2c1ccccc1>>CC(C)C(=O)O[C@@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@H]2CC[C@@H]1CC2c1ccccc1,[Pd],CCO,,,,val
US20060135517A1,CCCNC1COCCN1.Cc1cccc(-c2nc3ccccn3c2-c2ccnc(S(C)(=O)=O)n2)n1>>Cc1cccc(-c2nc3ccccn3c2-c2ccnc(NCCCN3CCOCC3)n2)n1,,CC#N,,,,val
US20150038438A1,COC(=O)c1c(O)c2c(n(Cc3ccc(OC)cc3OC)c1=O)-c1cc3cc(CO[Si](C)(C)C(C)(C)C)n(C)c3cc1CCC2>>COC(=O)c1c(O)c2c(n(Cc3ccc(OC)cc3OC)c1=O)-c1cc3cc(CO)n(C)c3cc1CCC2,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130065186A1,O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C(OCCC(F)(F)C(F)(F)S(=O)(=O)[O-])C12CC3CC(CC(O)(C3)C1)C2.[Na+]>>O=C(OC12CC3CC(C1)CC(C(=O)OCCC(F)(F)C(F)(F)S(=O)(=O)[O-])(C3)C2)C(F)(F)F.[Na+],,CCN(CC)CC,,ClCCl,,val
US20130296344A1,COc1cc(C=O)cc(Br)c1OC.Cc1ccc2cccc(O)c2n1.N#CCC#N>>COc1cc(C2C(C#N)=C(N)Oc3c2ccc2ccc(C)nc32)cc(Br)c1OC,,CCO,O,C1CN2CCN1CC2,,val
US05147880,COc1ccc2c3c(ccc2c1)-c1ccccc1C3c1ccc(O)cc1.ClCCN1CCCCC1>>COc1ccc2c3c(ccc2c1)-c1ccccc1C3c1ccc(OCCN2CCCCC2)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20040204427A1,COc1cc(NC(=O)OC(C)(C)C)ccc1F.Cl>>COc1cc(N)ccc1F.Cl,,C1COCCO1,,,,val
US20020072616A1,C/C(=C\CO)c1cccc([N+](=O)[O-])c1.O=C1CCC(=O)N1Cl>>C/C(=C\CCl)c1cccc([N+](=O)[O-])c1,,ClCCl,,CSC,,val
US20030060472A1,C=O.CC(=O)c1cc(O)c(O)c([N+](=O)[O-])c1.Cl.c1ccc(CC2CCNCC2)cc1>>Cl.O=C(CCN1CCC(Cc2ccccc2)CC1)c1cc(O)c(O)c([N+](=O)[O-])c1,,CC(C)O,,,,val
US20160096834A1,CC(C)(C)c1nc(C(=O)O)no1.Cn1cc(-c2nc3c(-c4cnc(CN)c(F)c4)ccnc3[nH]2)cn1>>Cn1cc(-c2nc3c(-c4cnc(CNC(=O)c5noc(C(C)(C)C)n5)c(F)c4)ccnc3[nH]2)cn1,,CN(C)C=O,ClCCl,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20150038438A1,C=CC(C)CI.C=Cc1cc2c(cc1C=O)cc(CO[Si](C)(C)C(C)(C)C)n2C>>C=Cc1cc2c(cc1C(O)CC(C)C=C)cc(CO[Si](C)(C)C(C)(C)C)n2C,,C1CCOC1,CCOCC,[Li]C(C)(C)C,,val
US20090286790A1,CCC1CC(N)CC(Cc2ccccc2)N1C(=O)OC(C)(C)C.Clc1ncc(Br)cn1>>CCC1CC(Nc2ncc(Br)cn2)CC(Cc2ccccc2)N1C(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US06222043B1,C(=NC1CCCCC1)=NC1CCCCC1.CCOC(C)=O.Cc1ccccc1CNC(=O)[C@H]1NCSC1(C)C.O=C([O-])O.On1nnc2ccccc21>>Cc1ccccc1CNC(=O)[C@H]1N(C(=O)[C@@H](O)[C@@H](N)Cc2ccccc2)CSC1(C)C,,CCOC(C)=O,,O,,val
US20040110804A1,CO.CON(Cc1ccc(F)c(Br)c1)C(=O)C=C1OC(C)(C)OC1=O>>COC(=O)C(O)=CC(=O)N(Cc1ccc(F)c(Br)c1)OC,,CO,,,,val
US20040072838A1,BrC(Br)(Br)Br.COc1ccc(CCc2sc(-c3ccc(C(F)(F)F)cc3)nc2CO)cc1C>>COc1ccc(CCc2sc(-c3ccc(C(F)(F)F)cc3)nc2CBr)cc1C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090186911A1,CCOC(=O)N=S(C)(=O)c1ccc(COc2cc(N=CN(C)C)c(C#N)cc2OC)cc1.Nc1nncs1>>CCOC(=O)N=S(C)(=O)c1ccc(COc2cc3ncnc(Nc4nncs4)c3cc2OC)cc1,,CO,,ClCCl,,val
US20030092677A1,Cc1cccc(-c2ccc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c3cccc(C#N)c3)c2)c1>>Cc1cccc(-c2ccc3c(c2)NC(=O)CC(c2cccc(C#N)c2)=N3)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120277217A1,CC(=O)Cl.NCc1ccccc1-c1cnc[nH]1>>CC(=O)NCc1ccccc1-c1c[nH]cn1,,ClCCl,,c1ccncc1,,val
US20070244125A1,BrCC1CC1.O=C(c1ccc2[nH]c(C(=O)N3CCC(F)(F)CC3)cc2c1)N1CCN(C2CCC2)CC1>>O=C(c1ccc2c(c1)cc(C(=O)N1CCC(F)(F)CC1)n2CC1CC1)N1CCN(C2CCC2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US04790868,COC(=O)Cn1c(=O)oc2ccc(O)cc21.Fc1cc(C(F)(F)F)cc(Cl)c1F>>COC(=O)Cn1c(=O)oc2ccc(Oc3c(F)cc(C(F)(F)F)cc3Cl)cc21,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080096878A1,COC(=O)Cn1c(=O)n(CC(=O)N(C)C)c2cc(C)cc(C)c21>>Cc1cc(C)c2c(c1)n(CC(=O)N(C)C)c(=O)n2CC(=O)O,,C1CCOC1,O,[Li+].[OH-],,val
US20060063759A1,CC(Cn1c(=O)[nH]c2cc(B3OC(C)(C)C(C)(C)O3)ccc21)N1CCOCC1.Fc1ccc2c(c1)OCc1ccccc1C2=CBr>>O=c1[nH]c2cc(C=C3c4ccccc4COc4cc(F)ccc43)ccc2n1CCCN1CCOCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20040192698A1,N#Cc1ccc(Cl)nc1.O=c1[nH]nc2c(N3CCNCC3)nc3ccc(F)cc3n12>>N#Cc1ccc(N2CCN(c3nc4ccc(F)cc4n4c(=O)[nH]nc34)CC2)nc1,,CCCCO,,O=C([O-])[O-].[Na+].[Na+],,val
US05089653,CCN(CC)CC.O=CO>>CC[NH+](CC)CC.O=C[O-],,CC#N,Cc1ccccc1,,,val
US07160887B1,CC(C)(C)OC(=O)NCc1cccc(Oc2ccccc2N(CCCCNC(=O)c2ccccc2F)C(=O)c2ccc(-c3ccccc3)cc2)c1.Cl>>Cl.NCc1cccc(Oc2ccccc2N(CCCCNC(=O)c2ccccc2F)C(=O)c2ccc(-c3ccccc3)cc2)c1,,CCOC(C)=O,,,,val
US04933333,CC(O)=S.COc1ccc(COC(=O)[C@@H]2C[C@@H](O)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)cc1>>COc1ccc(COC(=S)[C@@H]2C[C@H](C(C)=O)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140309238A1,N#Cc1nccs1.NO>>NC(=NO)c1nccs1,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US04844835,BrCCCCCCCCCCCCCCCCBr.CCOC(=O)c1ccc(-c2ccc(O)cc2)cc1>>CCOC(=O)c1ccc(-c2ccc(OCCCCCCCCCCCCCCCCBr)cc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150158847A1,COc1ccc(COc2ccc(Cn3cnc4cc(I)cnc43)cc2OC)cn1.N#C[Cu]>>COc1ccc(COc2ccc(Cn3cnc4cc(C#N)cnc43)cc2OC)cn1,,CN(C)C=O,,,,val
US20120232117A1,CCOC(=O)CC(=O)/C=C/c1ccccc1.NNc1ccccn1>>Oc1cc(C=Cc2ccccc2)nn1-c1ccccn1,,CC(=O)O,,,,val
US20160031843A1,CCNCC.O=Cc1ccco1>>CCN(CC)Cc1ccco1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120088746A1,CCOC(=O)c1ccc2nc(C(F)(F)F)nc(N3CCCCC3)c2c1.CO>>O=C(O)c1ccc2nc(C(F)(F)F)cc(N3CCCCC3)c2c1,,O,,Cl,[Li+].[OH-],val
US20090131379A1,C=C1[C@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C/C(=C/C(=O)OCC)C[C@@H]1F>>C=C1[C@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C/C(=C/CO)C[C@@H]1F,,Cc1ccccc1,ClCCl,CC(C)C[Al+]CC(C)C.[H-],,val
US06133253,CC(C)(C)OC(=O)N1CC[C@@H]1CO.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccccc1S(=O)(=O)OC[C@H]1CCN1C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,[Na+].[OH-],val
US20060004017A1,COc1cc2c(Cl)ncnc2cc1OCCCN(C)S(C)(=O)=O.Cc1ccnc2cc(O)ccc12>>Cc1ccnc2cc(Oc3ncnc4ccccc34)ccc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150141506A1,CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.COC(=O)c1ccc(C[C@@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@H]2O)cc1>>COC(=O)c1ccc(C[C@@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@H]2OC(=O)[C@@H](N)CC(C)C)cc1,CN(C)c1ccncc1,CCOC(C)=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US06492348B1,CC(=O)Cl.CC1(C)O[C@@H]2[C@@H](O1)[C@H](n1cnc3c(Nc4ccc(Cl)cc4F)ncnc31)O[C@@H]2C(=O)NN>>CC(=O)NNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(Cl)cc4F)ncnc32)[C@@H]2OC(C)(C)O[C@H]21,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20090054405A1,CCN.COc1ccc(S(=O)(=O)Cl)cc1>>CCNS(=O)(=O)c1ccc(OC)cc1,,ClCCl,,,,val
US20120196864A1,CCNC(=O)NCC#N.CCOc1cc(C=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F>>CCOc1cc(/C=C2\NC(=O)N(CC)C2=N)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,,CCO,,CC(C)(C)[O-].[K+],,val
US20120077781A1,CCOC(=O)CCCCCCn1c2nc(=O)[nH]c(=O)c-2nc2cc(C)c(Cl)cc21.OCCO>>Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCCCCCC(=O)O)c2cc1OCCO,,C1CCOC1,,CC(=O)O,[H-].[Na+],val
US04349684,CCOC(=O)CCCCCCCl.CCn1c(-c2ccccc2)c(-c2ccccc2)[nH]c1=O>>CCOC(=O)CCCCCCn1c(-c2ccccc2)c(-c2ccccc2)n(CC)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20050171130A1,CC(C)CC(C)O.Clc1cc(Cl)ncn1>>CC(C)CC(C)Oc1cc(Cl)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20150232481A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc3nn2c1N1CCC(C)(CC1)OCCCC[C@H](C)Oc1cc(C)ccc1C(C)OC3>>Cc1ccc2c(c1)O[C@@H](C)CCCCOC1(C)CCN(CC1)c1c([C@H](OC(C)(C)C)C(=O)O)c(C)nc3cc(nn13)CO[C@H]2C,,CCO,,[Na+].[OH-],,val
US06165943,C#CCBr.Nc1cccc2c1OC(F)(F)O2>>C#CCNc1cccc2c1OC(F)(F)O2,,Cc1ccccc1,,,,val
US05344843,COC(=O)C(=O)c1ccc(O)cc1.ClC/C=C\c1ccccc1>>COC(=O)C(=O)c1ccc(OC/C=C\c2ccccc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20160107997A1,CCOC(=O)CNc1cccc2ccncc12.CI>>CCOC(=O)CNc1cccc2cc[n+](C)cc12.[I-],,CC(C)=O,,,,val
US04165371,C=O.c1ccc2c(c1)C1CCNCC2C1>>CN1CCC2CC(C1)c1ccccc12,,O=CO,,[Na+].[OH-],,val
US20040181067A1,O=C(Nc1ncc(Br)s1)C(F)(F)F.O=S(=O)(c1ccccc1)N(F)S(=O)(=O)c1ccccc1>>O=C(Nc1ncc(F)s1)C(F)(F)F,,C1CCOC1,,O,[Li]CCCC,val
US20120184539A1,CC(CN=[N+]=[N-])(OS(C)(=O)=O)c1cc(Br)ncc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC1(c2cc(Br)ncc2F)CN1.O=P(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,,,val
US05935973,Cc1ccc(O)c(C=O)c1.Cc1ccc(S(=O)(=O)OC[C@H]2CO2)cc1>>Cc1ccc(OC[C@H]2CO2)c(C=O)c1,,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20090247567A1,CC(N)=O.CN(C(=O)c1cc2c(s1)-c1ccc(Br)cc1OCC2)c1ccccc1Cl>>CC(=O)Nc1ccc2c(c1)OCCc1cc(C(=O)N(C)c3ccccc3Cl)sc1-2,,C1COCCO1,,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20080004309A1,CCOC(=O)c1nc(Br)c2sc(-c3ccccc3)nc2c1O.OB(O)c1ccccc1>>CCOC(=O)c1nc(-c2ccccc2)c2sc(-c3ccccc3)nc2c1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140296252A1,Cc1nc(I)ccc1O.Clc1cc(Cl)ncn1>>Cc1nc(I)ccc1Oc1cc(Cl)ncn1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20050250797A1,CC(=O)N1CCNCC1.COCCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCCCl)c(OC)cc23)c2c1OCO2>>COCCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCCN4CCN(C(C)=O)CC4)c(OC)cc23)c2c1OCO2,,COCCO,,,,val
US20090029905A1,COC[C@H](C)Oc1cc(O)cc(C(=O)Nc2cc(C)n(C)n2)c1.O=C(c1cnc(Cl)c(Cl)c1)N1CCC1>>COC[C@H](C)Oc1cc(Oc2ncc(C(=O)N3CCC3)cc2Cl)cc(C(=O)Nc2cc(C)n(C)n2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20070185092A1,C#CCN.O=C(O)c1ccc(Cl)s1>>C#CCNC(=O)c1ccc(Cl)s1,,CN(C)C=O,ClCCl,,,val
US05554607,CC(C)NCC(=O)O.S=C=Nc1ccc2c(c1)CCC2>>CC(C)N1CC(=O)N(c2ccc3c(c2)CCC3)C1=S,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20140121198A1,CCOC(=O)Cl.N#CCc1nc2cnc3ccsc3c2n1[C@@H]1CC[C@@H](CN)CC1>>CCOC(=O)NC[C@@H]1CC[C@@H](n2c(CC#N)nc3cnc4ccsc4c32)CC1,,ClCCl,,CCN(CC)CC,,val
US20090131472A1,C#CC(=O)C(c1cccc(Cl)n1)c1c(Cl)cccc1Cl>>O=c1ccn2c(Cl)cccc2c1-c1c(Cl)cccc1Cl,,c1ccncc1,,,,val
US20160214977A1,CCI.O=Cc1ccc2[nH]c3cc(F)ccc3c2c1>>CCn1c2ccc(C=O)cc2c2ccc(F)cc21,,CN(C)C=O,Cc1ccccc1,O,[H-].[Na+],val
US20150329523A1,COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(N)c4ccccc34)n2)cc(OC)c1.COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Oc2ccccc2)cc1>>COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(OC)cc4)c4ccccc34)n2)cc(OC)c1,,CC(=O)OC(C)C,,CCN(CC)CC,,val
US20130131050A1,CCSc1nc2c(=O)[nH]ccc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1.CI>>CCSc1nc2c(=O)n(C)ccc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20050137240A1,O=C(NC1CCC(CNC(=S)NC(=O)c2ccccc2)CC1)OCc1ccccc1>>NC(=S)NCC1CCC(NC(=O)OCc2ccccc2)CC1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20090143366A1,Nc1ccc(Br)cc1C(=O)c1ccccc1F.O=C(Cl)CNC(=O)OCC1c2ccccc2-c2ccccc21>>O=C(CNC(=O)OCC1c2ccccc2-c2ccccc21)Nc1ccc(Br)cc1C(=O)c1ccccc1F,,ClC(Cl)Cl,,,,val
US05556858,BrCCCCBr.CC(c1ccc(Br)cc1)C1SCCCS1>>CC(c1ccc(CCCCBr)cc1)C1SCCCS1,,C1CCCCC1,C1CCOC1,CCOC(C)=O,,val
US05077304,CC(C)(C)N.CC(C)c1cc(Oc2ccc(Cl)cc2)nc(C(C)C)c1N=C=S>>CC(C)c1cc(Oc2ccc(Cl)cc2)nc(C(C)C)c1NC(=S)NC(C)(C)C,,Cc1ccccc1,,,,val
US03989718,CC(=O)CCl.COC(=O)c1sc2ccccc2c1O>>COC(=O)c1sc2ccccc2c1OCC(C)=O,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20120010182A1,CC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)ccc1O.COC(OC)N(C)C>>CN(C)/C=C/C(=O)c1cc(-c2ccc(C(F)(F)F)cc2)ccc1O,,CC(C)O,,,,val
US20060135525A1,CN(C)CCN.COC(=O)c1ccc(C=O)cc1>>COC(=O)c1ccc(CNCCN(C)C)cc1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20110142796A1,COc1cc(-c2cnc(N)nc2NC2CCCC2)c(OC)nn1>>COc1cc2c3cnc(N)nc3n(C3CCCC3)c2nn1,,CO,ClCCl,C1CCOC1,[H-].[Na+],val
US04985419,CC(C)I.CCNCC(C)N1c2ccccc2Sc2ccc(C#N)cc21>>CCN(CC(C)N1c2ccccc2Sc2ccc(C#N)cc21)C(C)C,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20070213331A1,Br[Mg]c1ccccc1.CC(=O)N1[C@@H](Cc2cc(F)cc(F)c2)[C@@H]([C@H]2CC(=O)CN2C(=O)OC(C)(C)C)OC1(C)C>>CC(=O)N1[C@@H](Cc2cc(F)cc(F)c2)[C@@H]([C@H]2C[C@](O)(c3ccccc3)CN2C(=O)OC(C)(C)C)OC1(C)C,,CCOC(C)=O,CCOCC,,,val
US20150087847A1,CCCc1ccc(-c2ccc(B(O)O)c(F)c2)cc1.Fc1cc(F)cc(Br)c1>>CCCc1ccc(-c2ccc(-c3cc(F)cc(F)c3)c(F)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20110071143A1,O=C1COC[C@@H](c2cccc(F)c2)N1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>Fc1cccc([C@@H]2COCC(=S)N2)c1,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20120270838A1,CC(=O)OC[C@H](CN(C(C)=O)c1ccc(CCS(=O)(=O)N2CCC3(CC2)N=C(c2ccc(C(F)(F)F)cc2)NC3=O)c(C)c1)OC(C)=O>>Cc1cc(NC[C@H](O)CO)ccc1CCS(=O)(=O)N1CCC2(CC1)N=C(c1ccc(C(F)(F)F)cc1)NC2=O,,CO,,[K+].[OH-],,val
US20140275080A1,Cc1cn(-c2cc(Oc3ccc([N+](=O)[O-])nc3C)ccn2)cn1>>Cc1cn(-c2cc(Oc3ccc(N)nc3C)ccn2)cn1,[Zn],CO,ClCCl,[Cl-].[NH4+],,val
US20130289033A1,O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(I)cc1.OB(O)c1cccc(C(F)(F)F)c1>>O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(-c2cccc(C(F)(F)F)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20140221338A1,CC(=O)C(=CN(C)C)C(=O)OC(C)(C)C.Cc1ccnc(-n2ncc(C(=O)O)c2C)c1F>>Cc1ccnc(-n2ncc(C(=O)OC(C)(C)C)c2C)c1F,,CC#N,,CCN(CC)CC,,val
US20150305332A1,CO.O=C(O)c1cccc2sc(C(F)(F)F)cc12>>COC(=O)c1cccc2sc(C(F)(F)F)cc12,,CO,,C[Si](C)(C)C=[N+]=[N-],,val
US20050234046A1,COC(=O)Cc1cc([N+](=O)[O-])cc(C)c1Br>>COC(=O)Cc1cc(N)cc(C)c1Br,[Fe],O,,CC(=O)O,,val
US04939165,CC(C)Cl.c1ccc(-c2ccc(-c3cccs3)s2)cc1>>CC(C)c1ccc(-c2ccc(-c3ccccc3)s2)s1,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20090131458A1,Nc1nc(NCCC2CC2)nc2c1ncn2C1CCCCO1.O=C1CCC(=O)N1Br>>Nc1nc(NCCC2CC2)nc2c1nc(Br)n2C1CCCCO1,,ClC(Cl)Cl,ClCCl,,,val
US20030139433A1,CN(C[C@@H](CCN1CCC(N2CCCNC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1.O=C(O)/C=C\C(=O)O>>CN(C[C@@H](CCN1CCC(N2CCCNC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1.O=C(O)/C=C\C(=O)O,,CCO,CCOC(C)=O,,,val
US20020156077A1,COc1ccc2c(c1)OC(c1ccc(OCCN3CCCCC3)cc1)c1cc(C(C)=O)ccc1-2>>CC(=O)c1ccc2c(c1)C(c1ccc(OCCN3CCCCC3)cc1)Oc1cc(O)ccc1-2,,ClCCl,,BrB(Br)Br,,val
US20100292128A1,COC(=O)[C@H]1C(C)=C[C@H](OC(C)=O)CC12CCCC2>>COC(=O)C1=C(C)C=CCC12CCCC2,,Cl,,C1CCC2=NCCCN2CC1,,val
US04769367,Cl.c1ccc(CN2C[C@@H]3Cc4ccccc4O[C@H]3C2)cc1>>Cl.c1ccc2c(c1)C[C@H]1CNC[C@@H]1O2,[Pd],CO,,[H][H],,val
US20130005743A1,COc1ccc(-n2nc(C)c3c(C(=O)Nc4c(C)ccnc4C)cc(C)nc32)cc1>>Cc1cc(C(=O)Nc2c(C)ccnc2C)c2c(C)nn(-c3ccc(O)cc3)c2n1,,ClCCl,,BrB(Br)Br,,val
US04062965,CCCCCCCCCCCCBr.CCCCCCCCCCCCn1ccnc1C>>CCCCCCCCCCCCN1C=CN(CCCCCCCCCCCC)C1C.[Br-],,CC(C)O,,,,val
US20070254880A1,CC(C)(NC(=O)c1ccc(Cl)cc1Cl)C1(c2ccccn2)CCNCC1.O=S(=O)(Cl)NN1CCC1>>CC(C)(NC(=O)c1ccc(Cl)cc1Cl)C1(c2ccccn2)CCN(S(=O)(=O)N2CCC2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20140142081A1,CCOC(=O)Cc1ccc(N)cc1.CS(=O)(=O)Cl>>CCOC(=O)Cc1ccc(NS(C)(=O)=O)cc1,,ClCCl,,CCN(CC)CC,,val
US20160221989A1,CC1CN(C(=O)OC(C)(C)C)CC1O.CS(=O)(=O)Cl>>C[C@H]1CN(C(=O)OC(C)(C)C)C[C@H]1OS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US06200980B1,CCCc1nn(C)c2c(=O)[nH]c(-c3cc([N+](=O)[O-])ccc3OCC)nc12>>CCCc1nn(C)c2c(=O)[nH]c(-c3cc(N)ccc3OCC)nc12,[Pd],CCO,,,,val
US20080207608A1,CC(=O)c1ccc2nc(C)ccc2c1.COC(=O)NN>>COC(=O)NNC(C)c1ccc2nc(C)ccc2c1,,Cc1ccccc1,O,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US04873358,CCOC(=O)C#N.C[N+](=O)[O-]>>CCOC(=O)C[N+](=O)[O-],,CC(=O)O,,CS(C)=O,[H-].[Na+],val
US20130296317A1,CC(CNC(=O)OC(C)(C)C)C(=O)C1C(=O)OC(C)(C)OC1=O>>CC1CN(C(=O)OC(C)(C)C)C(=O)CC1=O,,CCOC(C)=O,,,,val
US20070032519A1,CC(C)[Si](C(C)C)(C(C)C)n1cc(C(O)c2ccc(C(=O)Nc3ccc(Cl)cc3)nc2)c2cccnc21>>O=C(Nc1ccc(Cl)cc1)c1ccc(Cc2c[nH]c3ncccc23)cn1,,CC#N,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20080182852A1,CC(C)NC(=O)c1ccccc1N.Clc1ncc(Cl)c(Cl)n1>>CC(C)NC(=O)c1ccccc1Nc1nc(Cl)ncc1Cl,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20090306133A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(CCN)CC1>>CC(=O)NCCC1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,O=C([O-])O.[Na+],,val
US04496586,C#CC(C)C(O)c1ccco1>>C#CC(C)C1C(=O)C=CC1O,,CC(C)=O,O,O=C([O-])O.[Na+],,val
US20040082571A1,COc1cc(N2CCN(C(=O)CCl)CC2)ccc1Br.FC(F)(F)c1n[nH]c(-c2ccccc2)c1Cl>>COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3-c3ccccc3)CC2)ccc1Br,,CCCCCC,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160185779A1,C=CC(=O)OCC.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C[C@H](C)N>>COC(=O)CCN(C(=O)OC(C)(C)C)[C@@H](C)CC(=O)OC,,CO,,[Na+].[OH-],,val
US20120252779A1,CCOC(=O)c1cccc(N2CCN(C(=O)OC(C)(C)C)CC2)c1>>CC(C)(C)OC(=O)N1CCN(c2cccc(CO)c2)CC1,,C1CCOC1,,[BH4-].[Li+],,val
US20160052930A1,CC(C)(C)OC(=O)N1[C@H]2CC[C@@H]1CN(Cc1ccccc1)C2>>CC(C)(C)OC(=O)N1[C@H]2CC[C@@H]1CNC2,[Pd],CO,,,,val
US20110070193A1,COc1c(/C=C/c2ccc(NS(C)(=O)=O)cc2C(=O)Cl)cc(-n2ccc(=O)[nH]c2=O)cc1C(C)(C)C.c1c[nH]nn1>>COc1c(/C=C/c2ccc(NS(C)(=O)=O)cc2-c2ncco2)cc(-n2ccc(=O)[nH]c2=O)cc1C(C)(C)C,,O=S1(=O)CCCC1,,O=C([O-])[O-].[K+].[K+],,val
US20130040931A1,CI.Cc1cccc(NC(=O)CC(C)(C)C)c1Br>>Cc1cccc(N(C)C(=O)CC(C)(C)C)c1Br,,C1CCOC1,CCOC(C)=O,O,[H-].[Na+],val
US05753679,Cc1ccc(CN2CCC(O)CC2)cc1.O=C(Cl)c1ccccc1>>Cc1ccc(CN2CCC(OC(=O)c3ccccc3)CC2)cc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20040199002A1,COC(=O)c1cccc(C)c1[N+](=O)[O-].COC(OC)N(C)C>>COC(=O)c1cccc(CC=O)c1[N+](=O)[O-],,CN(C)C=O,,Cl,,val
US20090156619A1,CC(C)(C)OC(=O)N[C@@H](CCCCN)c1ncc(-c2ccc3ccccc3c2)[nH]1.CN=C=O>>CNC(=O)NCCCC[C@H](NC(=O)OC(C)(C)C)c1ncc(-c2ccc3ccccc3c2)[nH]1,,CN(C)C=O,ClCCl,O=C([O-])O.[Na+],,val
US20060009511A9,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCc1c[nH]c2cc(Cl)ccc12>>CC(C)(C)OC(=O)NCCc1c[nH]c2cc(Cl)ccc12,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20040034004A1,CC(C)C(O)c1ccc2c(c1)C(C)(C)CO2>>CC(C)C(=O)c1ccc2c(c1)C(C)(C)CO2,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20140256736A1,COc1ccc(CNc2ncccn2)c(OC)c1.O=S(=O)(Cl)c1ccc(F)c(F)c1>>COc1ccc(CN(c2ncccn2)S(=O)(=O)c2ccc(F)c(F)c2)c(OC)c1,,C1CCOC1,CCOC(C)=O,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20130190307A1,BrBr.Oc1cnc2ccccc2n1>>Oc1cnc2ccc(Br)cc2n1,,CC(=O)O,,,,val
US04234744,CCCCC(NC(=O)OC)C(=O)OC.Cl>>CCCCC(N)C(=O)O.Cl,,O,,O=CO,,val
US06100421,CI.Cc1c(O)cccc1Cl>>COc1cccc(Cl)c1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05153207,CCOC(=O)CCN1CCC(OC(c2ccc(C)cc2)c2ccc(C)cc2)CC1.Cl>>Cc1ccc(C(OC2CCN(CCC(=O)O)CC2)c2ccc(C)cc2)cc1.Cl,,CO,,[Na+].[OH-],,val
US20080175814A1,Cc1cc(Nc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)nc(N)n1.Cl>>Cc1cc(Nc2ccc(NC(=O)c3ccc(N)cc3)cc2)nc(N)n1.Cl,[Fe],O,,CCO,,val
US20050020605A1,CCO/N=C(\c1ccc(Br)cc1)C1CCN(C2(C)CCNCC2)CC1.Cn1ccc2c(C(=O)O)cccc21>>CCO/N=C(\c1ccc(Br)cc1)C1CCN(C2(C)CCN(C(=O)c3cccc4c3ccn4C)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120040957A1,COc1ccc2ncc(OCCN3CCC(NC(=O)OC(C)(C)C)CC3)nc2c1>>COc1ccc2ncc(OCCN3CCC(N)CC3)nc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05304563,C=Cc1cc(CC(=O)OC)ccc1OCc1ccc2ccccc2n1>>CCc1cc(CC(=O)OC)ccc1OCc1ccc2ccccc2n1,[Pd],CC(=O)O,CO,,,val
US20110152290A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OCC(F)(F)c1cccc(Cl)c1>>O=S(=O)(OCC(F)(F)c1cccc(Cl)c1)C(F)(F)F,,ClCCl,,CO,,val
US20100197706A1,CCCC(CCC)n1cnc2c(C(=O)N[C@@H](Cc3ccccc3)[C@H](O)CNCc3cccc(C(F)(F)F)c3)cccc2c1=O.Cl>>CCCC(CCC)n1cnc2c(C(=O)N[C@@H](Cc3ccccc3)[C@H](O)CNCc3cccc(C(F)(F)F)c3)cccc2c1=O.Cl,,C1COCCO1,CCOCC,,,val
US20150368248A1,COc1ccccc1-c1ccc(CNc2nc(NC3CCC(N)CC3)nc3c2ncn3C2CCCC2)cn1>>NC1CCC(Nc2nc(NCc3ccc(-c4ccccc4O)nc3)c3ncn(C4CCCC4)c3n2)CC1,,ClCCl,,CO,,val
US20090291955A1,O=C(O)CC(=O)O.O=Cc1csc(N2CCC(Oc3ccccc3C(F)(F)F)CC2)n1>>O=C(O)C=Cc1csc(N2CCC(Oc3ccccc3C(F)(F)F)CC2)n1,,c1ccncc1,,C1CCNCC1,,val
US20090054425A1,Nc1cc(=O)[nH]c(=O)[nH]1.O=CCCl>>Oc1nc(O)c2cc[nH]c2n1,,O,,CC(=O)[O-].[Na+],,val
US20080125468A1,CCCCC(O)c1ccc(-c2ccc(C(F)(F)F)cn2)cc1.COC(=O)CCNC(=O)c1ccc(O)cc1>>CCCCC(Oc1ccc(C(=O)NCCC(=O)OC)cc1)c1ccc(-c2ccc(C(F)(F)F)cn2)cc1,,Cc1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20040171570A1,COc1ccc(C(OC(c2ccccc2)C2OC(n3ccc(=O)[nH]c3=O)C(OC(C)=O)C2O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c2ccc(OC)cc2)cc1>>CC(=O)OC1C(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C(CO)OC1n1ccc(=O)[nH]c1=O,,CC(=O)O,,,,val
US20040053946A1,CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1.O=Cc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1.[OH-]>>Cc1ccc(S(=O)(=O)O)cc1.O=Cc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1,,C1CCOC1,,Cl,,val
US05972951,CC(=O)N1CCc2cc(O)c(Br)cc21.CN1CC=C(CO)CC1>>CC(=O)N1CCc2cc(OCC3=CCN(C)CC3)c(Br)cc21,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150018363A1,Cc1c(C2CC2)nc2ccc(-n3ccc(O)cc3=O)cn12.OCc1ccc(C(F)(F)F)s1>>Cc1c(C2CC2)nc2ccc(-n3ccc(OCc4ccc(C(F)(F)F)s4)cc3=O)cn12,,C1CCOC1,O,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20120220575A1,BrCc1ccccc1.Clc1ncc2c(n1)N1CCOCC1CN2>>Clc1ncc2c(n1)N1CCOCC1CN2Cc1ccccc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US05459138,CN1CNS(=O)(=O)c2cnccc21.COS(=O)(=O)c1ccc(C)cc1>>CN1CN(C)S(=O)(=O)c2cnccc21,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110053909A1,CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cccc(CCOCCC(=O)O)c4F)CC3)C2)cs1.COC(CNCC(F)(F)F)OC>>COC(CN(CC(F)(F)F)C(=O)CCOCCc1cccc(CN2CCC3(CC2)CN(C(=O)c2csc(C(C)C)n2)CCO3)c1F)OC,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04546191,FC(F)(F)c1cnc(Cl)c(Cl)c1.[OH-]>>O=c1[nH]cc(C(F)(F)F)cc1Cl,,CC(C)(C)O,,Cl,,val
US20100056508A1,C=CC(=O)OC(C)(C)C.NCCc1cccc(F)c1>>CC(C)(C)OC(=O)CCNCCc1cccc(F)c1,,CCO,,,,val
US20040162321A1,CC(C)=CC(=O)Oc1ccc(F)cc1>>CC1(C)CC(=O)Oc2ccc(F)cc21,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04917826,COc1ccc2c(c1)CC[C@H]1[C@@H]3CCC(=O)[C@@]3(C)CC[C@H]21.NCCc1ccccn1.O=CO>>COc1ccc2c(c1)CC[C@H]1[C@@H]3CC[C@H](NC=O)[C@@]3(C)CC[C@H]21,,O=CO,,[Na+].[OH-],,val
US20150299189A1,CCOCCCc1cc(Nc2ncc(C3CC3)cc2C(=O)OC)cc2ccn(C)c12>>CCOCCCc1cc(Nc2ncc(C3CC3)cc2C(=O)O)cc2ccn(C)c12,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20100063081A1,CSc1ccc(N)cc1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CSc1ccc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])cc1,,ClCCl,,c1ccncc1,,val
US20120196864A1,CCN1C(=O)NC(=C\c2ccc(OCc3ccc(C(F)(F)F)cc3C(F)(F)F)c(OC)c2)/C1=N\C.CI>>CCN1C(=O)N(C)C(=C\c2ccc(OCc3ccc(C(F)(F)F)cc3C(F)(F)F)c(OC)c2)/C1=N\C,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20060004084A1,O=C1OC(c2ccccc2)c2cc(CO)ccc21>>O=Cc1ccc2c(c1)C(c1ccccc1)OC2=O,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US05534535,CC(=O)OCC1CC(n2c(Br)nc3cc(Cl)c(Cl)cc32)C(OC(C)=O)C1OC(C)=O.NN>>Nc1nc2cc(Cl)c(Cl)cc2n1C1CC(CO)C(O)C1O,,CCO,,O,,val
US20030195216A1,CCOC(=O)CCCBr.COc1ccc(O)c(OC)c1OC>>CCOC(=O)CCCOc1cc(OC)c(OC)c(OC)c1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05591751,CCOC(=O)c1cc(OC)c2[nH]c(=O)ccc2c1>>CCOC(=O)c1cc2c(c(OC)c1)NC(=O)CC2,[Pd],CC(=O)O,,,,val
US08697725B2,CC(=O)N1c2ccc(B3OC(C)(C)C(C)(C)O3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.CC(C)(C)N(CCc1ccc(Br)cc1)C(=O)[O-]>>CC(=O)N1c2ccc(-c3ccc(CCNC(=O)OC(C)(C)C)cc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20140288045A1,CC(C)(C)OC(=O)N1CCN(CCBr)CC1.COc1cc(Cl)c(I)cc1N>>COc1cc(Cl)c(I)cc1NCCN1CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,[H-].[Na+],,val
US20050261291A1,CC1(C)C=C(c2ccccc2[N+](=O)[O-])CC1(C)C>>CC1(C)C=C(c2ccccc2N)CC1(C)C,[Fe],O,,CCO,[Cl-].[NH4+],val
US20120088755A1,Clc1cc(Cl)ncn1.O=c1[nH]c2ccc(O)cc2o1>>O=c1[nH]c2ccc(Oc3cc(Cl)ncn3)cc2o1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20020061872A1,CCOC(=O)C(F)(F)c1ccc(F)c2ccccc12>>O=C(O)C(F)(F)c1ccc(F)c2ccccc12,,CO,O,C1CCOC1,[Na+].[OH-],val
US20130317100A1,CCCC/C(=C\C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1)N(C)C.CS(=O)(=O)N=C1C=CC(=O)C=C1>>CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1,,CC(=O)O,CN(C)C=O,,,val
US20150105367A1,Cc1nc2cc(Cl)ncc2cc1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1nc2cc(Cl)ncc2cc1OS(=O)(=O)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US20140343032A1,CC(=O)n1cccn1.CC(C)(C)OC(=O)N1C2COCC1CC(=O)C2>>CC(=O)C1C(=O)CC2COCC1N2C(=O)OC(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20040167224A1,CC(C)(C)OC(=O)N1CCC(S(=O)(=O)Cc2ccccc2F)CC1.Cl>>Cl.O=S(=O)(Cc1ccccc1F)C1CCNCC1,,CCOC(C)=O,,,,val
US20160213653A1,CC(C)(C)OC(=O)NC1CN(c2cnc3[nH]ccc3c2)C1.O=C1CCC(=O)N1I>>CC(C)(C)OC(=O)NC1CN(c2cnc3[nH]cc(I)c3c2)C1,,CN(C)C=O,,O,,val
US20110230462A1,C[Si](C)(C)C#Cc1cnc2c(n1)c(C(=O)N[C@@H](C(=O)N1CCC(C#N)CC1)C1CC1)cn2COCC[Si](C)(C)C>>C#Cc1cnc2c(n1)c(C(=O)N[C@@H](C(=O)N1CCC(C#N)CC1)C1CC1)cn2COCC[Si](C)(C)C,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20130338140A1,CC(C)(C)OC(=O)N1CCN(C(=O)N2CCc3cnc(NC4CCOCC4)nc3C2)C(c2ccccc2)C1>>O=C(N1CCc2cnc(NC3CCOCC3)nc2C1)N1CCNCC1c1ccccc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US07803359B1,CC(N)=O.COc1ccc(N)cc1OC>>COc1ccc(NC(C)=O)cc1OC,,CC(=O)O,,CC(=O)OC(C)=O,,val
US05654472,CC(=O)OC(C)=O.OCC(O)(CO)c1ccc(F)cc1F>>CC(=O)OCC(O)(COC(C)=O)c1ccc(F)cc1F,,c1ccncc1,,CCOC(C)=O,,val
US20110053940A1,CCOC(=O)C1=C(c2ccncc2OCOC)CCN(C(=O)OC(C)(C)C)C1>>CCOC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1c1ccncc1OCOC,,CO,,[Mg],,val
US20110311474A1,O=C(Cl)OC1CCCC1.c1cc2c(ncc3cnc([C@@H]4CCCNC4)n32)[nH]1>>O=C(OC1CCCC1)N1CCC[C@@H](c2ncc3cnc4[nH]ccc4n23)C1,,C1CCOC1,ClCCl,Cl,,val
US20100069381A1,COc1ccc(-n2cnc3ccc(C(=O)NN)cc32)cc1.S=C=S>>COc1ccc(-n2cnc3ccc(-c4nnc(S)o4)cc32)cc1,,CCO,,[K+].[OH-],,val
US20060116400A1,CCOC(CC1CC(c2ccc(Br)cn2)=NO1)OCC.O=C1O[C@@H](Cn2ccnn2)CN1c1ccc(-c2ccc(C3=NOC(CO)C3)[n+]([O-])c2)c(F)c1>>CCOC(CC1CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cn2)=NO1)OCC,c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd-4]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20080207666A1,CC(C)OC(=O)N=NC(=O)OC(C)C.CC1(C)C[C@H](O)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1.c1c[nH]cn1>>CC1(C)C[C@@H](N=[N+]=[N-])c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20080200338A1,C=CC=O.CCOC(=O)CNC(=O)c1cn(C)nc1C(F)(F)F>>C=CC(O)C(NC(=O)c1cn(C)nc1C(F)(F)F)C(=O)OCC,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20070135430A1,CCOC(=O)CBr.C[C@@H](Cn1ncc2ccc(O)c(C=O)c21)NC(=O)OCc1ccccc1>>CCOC(=O)c1cc2c(ccc3cnn(C[C@H](C)NC(=O)OCc4ccccc4)c32)o1,,CCOC(C)=O,CN(C)C=O,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20080070928A1,O=C(Nc1ccc(C2CCCN2C(=O)C(F)(F)F)c(F)c1)C(F)(F)F.O=[N+]([O-])O>>O=C(Nc1cc(F)c(C2CCCN2C(=O)C(F)(F)F)cc1[N+](=O)[O-])C(F)(F)F,,O,,,,val
US20090169558A1,CC(C)CC=O.Nc1nc2[nH]c(-c3ccnc(Cl)c3)cc2c(=O)[nH]1>>CC(C)CCNc1nc2[nH]c(-c3ccnc(Cl)c3)cc2c(=O)[nH]1,,CC(=O)O,CN(C)C=O,[BH3-]C#N.[Na+],,val
US20110257161A1,Nc1ccc(N2CCN3CCC2CC3)cc1.O=C(Cl)c1ccccc1[N+](=O)[O-]>>O=C(Nc1ccc(N2CCN3CCC2CC3)cc1)c1ccccc1[N+](=O)[O-],,COCCOC,,[Na+].[OH-],,val
US20020193447A1,CC(C)(C)[Si](C)(C)Oc1ccc([C@H](O)C[N+](=O)[O-])cc1O[Si](C)(C)C(C)(C)C>>CC(C)(C)[Si](C)(C)Oc1ccc([C@H](O)CN)cc1O[Si](C)(C)C(C)(C)C,[Pd],CO,,[H][H],,val
US06087304,COC(=O)COc1ccc2cc(C(=O)OC)ccc2c1>>COC(=O)c1ccc2cc(OCC(=O)O)ccc2c1,,CN(C)C=O,O,Cl,[K+].[OH-],val
US20070232649A1,CCOc1cccc(C=O)c1O.Nc1cc(NS(=O)(=O)CC(=O)O)ccc1F>>CCOc1cccc2cc(S(=O)(=O)Nc3ccc(F)c(N)c3)c(=O)oc12,,CC(=O)O,,,,val
US20040006245A1,C[Si](C)(C)C#Cc1ccc(N)c(F)c1.O=C(O)c1ccc(F)c(F)c1F>>C[Si](C)(C)C#Cc1ccc(Nc2c(C(=O)O)ccc(F)c2F)c(F)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20060004195A1,CC1(C)OC(=O)C(Cc2cc(-c3ccc4c(c3)OCO4)n(-c3cc(Cl)ccc3Cl)n2)(c2cccc(Cl)c2)O1.CO>>COC(=O)C(O)(Cc1cc(-c2ccc3c(c2)OCO3)n(-c2cc(Cl)ccc2Cl)n1)c1cccc(Cl)c1,,CO,,O,C[O-].[Na+],val
US20090082330A1,Cc1c(NC(=O)c2cc3c(s2)C(=O)CCC3)cccc1-c1cn(C)c(=O)c(Nc2ccc(C3C(=O)N(C)CCN3C)cc2)n1>>Cc1c(NC(=O)c2cc3c(s2)C(O)CCC3)cccc1-c1cn(C)c(=O)c(Nc2ccc(C3C(=O)N(C)CCN3C)cc2)n1,,CO,,[BH4-].[Na+],,val
US20070254866A1,COc1ccc(CNc2c(F)c(NCCNc3ccccn3)c3c4c2c(=O)c(C(=O)O)cn4[C@@H](c2ccccc2)CO3)cc1>>Nc1c(F)c(NCCNc2ccccn2)c2c3c1c(=O)c(C(=O)O)cn3[C@@H](c1ccccc1)CO2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080090861A1,Cc1cnn(-c2cccc(C)n2)c1.O=C1CCC(=O)N1Br>>Cc1cccc(-n2ncc(C)c2Br)n1,,C1CCOC1,CCOC(C)=O,[Li]CCCC,[Cl-].[NH4+],val
US20120010191A1,CCOC(=O)c1cc2c(n1CC#N)CCCC2>>CCOC(=O)c1cc2c(n1CCN)CCCC2,[Pd],CCO,,CCOC(C)=O,Cl,val
US20090018132A1,C=O.CC(OCC1(c2ccc(F)cc2)CCNCC1)c1cc(C2CC2)cc2cn[nH]c12>>CC(OCC1(c2ccc(F)cc2)CCN(C)CC1)c1cc(C2CC2)cc2cn[nH]c12,CC(=O)O,CC#N,,[BH3-]C#N.[Na+],,val
US20100093757A1,Cc1c(F)cccc1-n1ncc2c(O[C@@H](COCCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)C(=O)Nc3ccc(Cl)cn3)ncnc21>>Cc1c(F)cccc1-n1ncc2c(O[C@@H](COCCO)C(=O)Nc3ccc(Cl)cn3)ncnc21,,C1CCOC1,CCOC(C)=O,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20030199440A1,C[C@@H](C(=O)OC(C)(C)C)N(Cc1ccccc1)S(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1.N=C(N)N>>C[C@@H](C(=O)OC(C)(C)C)N(Cc1ccccc1)S(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1,,COCCOC,,Cl,[H-].[Na+],val
US20150025054A1,CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(OCc2ccccc2F)cc1>>N[C@@H]1C[C@H]1c1ccc(OCc2ccccc2F)cc1,,C1COCCO1,,Cl,,val
US04661438,CCOS(=O)(=O)C(F)(F)F.COc1cc2nc(C)[te]c2cc1OC>>CC[n+]1c(C)[te]c2cc(OC)c(OC)cc21.O=S(=O)([O-])C(F)(F)F,,ClC(Cl)Cl,,CCOCC,,val
US20160016935A1,CCOc1ccnc(Cl)c1.C[C@@H]1CC[C@@H](O)CN1C(=O)c1ccccc1-n1nccn1>>CCOc1ccnc(O[C@@H]2CC[C@@H](C)N(C(=O)c3ccccc3-n3nccn3)C2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20040110811A1,CC1(C)NC(=O)N(C(=O)c2cccc3ccccc23)C1=O.Clc1ccc(CBr)cc1>>CC1(C)C(=O)N(C(=O)c2cccc3ccccc23)C(=O)N1Cc1ccc(Cl)cc1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20060183780A1,Nc1cccnc1Cl.O=c1c2ccnn2c(=O)c2ccnn12>>O=C(Nc1cccnc1Cl)c1cc[nH]n1,CN(C)c1ccncc1,CCOC(C)=O,,O,,val
US20120202691A1,CI.Cc1sc(-c2ccc(Cl)cc2)nc1C1C(=O)CCC1=O>>COC1=C(c2nc(-c3ccc(Cl)cc3)sc2C)C(=O)CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120101100A1,CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2cncc(-c3nnc(C(C)(C)OC(C)=O)o3)c2)cn1>>CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2cncc(-c3nnc(C(C)(C)O)o3)c2)cn1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20090062334A1,CCC(CC)CO.Cc1ccc(S(=O)(=O)Cl)cc1>>CCC(CC)COS(=O)(=O)c1ccc(C)cc1,,ClCCl,,C1CN2CCN1CC2,,val
US03933804,CC(=CCBr)CBr.OCc1ccc2c(c1)OCO2>>CC(=CCOCc1ccc2c(c1)OCO2)CBr,,COCCOC,,[Na],,val
US20080182852A1,CC(C)NC(=O)c1ccccc1Nc1nc(Nc2ccc(C=O)cc2)ncc1F.CS(=O)(=O)CCN>>CC(C)NC(=O)c1ccccc1Nc1nc(Nc2ccc(CNCCS(C)(=O)=O)cc2)ncc1F,,ClCCl,,,,val
US20120316195A1,C[Mg]Br.O=Cc1c(Cl)cncc1Br>>CC(O)c1c(Cl)cncc1Br,,C1CCOC1,,[Cl-].[NH4+],,val
US20080171737A1,C=C(CCl)CC1Cc2ccccc2N(c2ccccc2)S1(=O)=O.CN>>C=C(CNC)CC1Cc2ccccc2N(c2ccccc2)S1(=O)=O.Cl,,CCO,,,,val
US06313127B1,CCOC(C)=O.CN(C)C=O.O=C(c1ncc[nH]1)c1ncc[nH]1.O=S(O)c1ccc2cc(Br)ccc2c1>>Brc1ccc2cc(SN3CCN(c4ccncc4)CC3)ccc2c1,,CN(C)C=O,,,,val
US20160222033A1,NC(N)=S.O=C1CCCC1Br>>Nc1nc2c(s1)CCC2,,CCO,,O=C([O-])O.[Na+],,val
US20110112080A1,CC(C)(C)OC(=O)N[C@H](CO)CCc1ccc(Br)cc1>>CC(C)(C)OC(=O)N[C@H](C=O)CCc1ccc(Br)cc1,,CS(C)=O,,CCN(CC)CC,CCOC(C)=O,val
US20080139561A1,C[C@H](N)c1ccc(F)cn1.N#Cc1cc(F)c(Nc2cc(C3CC3)[nH]n2)nc1F>>C[C@H](Nc1nc(Nc2cc(C3CC3)[nH]n2)c(F)cc1C#N)c1ccc(F)cn1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20120220013A1,CC(C)(C)[Si](C)(C)Cl.OCc1ccco1>>CC(C)(C)[Si](C)(C)OCc1ccco1,,CN(C)C=O,,c1c[nH]cn1,,val
US20010001799A1,CC(C)[N+](=O)[O-].COc1cc(C)cc(CBr)c1>>COc1cc(C)cc(C=O)c1,,CCO,,C,C[O-].[Na+],val
US20130310419A1,CN1C(=O)CC(C)(C)c2ccccc21.O=C(Br)CBr>>CN1C(=O)CC(C)(C)c2cc(C(=O)CBr)ccc21,,S=C=S,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US06174881B1,CCOC(OCC)C(CO)NC1=Nc2ccc(Cl)cc2C(c2ccccc2F)=NC1>>OCc1cn2c(n1)CN=C(c1ccccc1F)c1cc(Cl)ccc1-2,,CC(=O)O,,,,val
US06051583,COc1cccc2c1C[C@H]1N(C=O)CC[C@]1(C)C2(C)C>>COc1cccc2c1C[C@H]1NCC[C@]1(C)C2(C)C,,CCCO,O,Cl,,val
US20150126490A1,CC(=O)Cl.Nc1ncc(C2CCNCC2)nc1Br>>CC(=O)N1CCC(c2cnc(N)c(Br)n2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130065906A1,Clc1ccc(Cl)nc1.O=C(c1ccc(-c2cnco2)cc1)N(C1CCNCC1)C1CC1>>O=C(c1ccc(-c2cnco2)cc1)N(C1CC1)C1CCN(c2ccc(Cl)cn2)CC1,,CN1CCCC1=O,,Cl,,val
US20150133424A1,COc1ccc(Cn2c(=O)c3c(Nc4cccc(CCC(N)=O)c4)c(C)c(=O)n(C)c3n(-c3ccc(I)cc3F)c2=O)cc1>>COc1ccc(Cn2c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c3n(-c3cccc(CCC(N)=O)c3)c2=O)cc1,,C1CCOC1,,C[O-].[Na+],,val
US20020072597A1,CCI.CO[C@@H]1O[C@H](c2nnc[nH]2)[C@H]2OC(C)(C)O[C@@H]12>>CCn1cnc([C@H]2O[C@@H](OC)[C@@H]3OC(C)(C)O[C@@H]32)n1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120108619A1,CC(C)n1ncc(CC2(C(=O)O)CCN(C(=O)OC(C)(C)C)CC2)c1Br.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)n1ncc(CC2(N=C=O)CCN(C(=O)OC(C)(C)C)CC2)c1Br,,Cc1ccccc1,,CCN(CC)CC,,val
US20120214803A1,O=[N+]([O-])c1ccc(Cl)c2cccnc12>>Nc1ccc(Cl)c2cccnc12,[Ni],C1CCOC1,CO,NN,O,val
US20110065681A1,Brc1nccs1.COC(=O)c1cc(O)cc(-c2ccc(C)cn2)c1>>COC(=O)c1cc(Oc2nccs2)cc(-c2ccc(C)cn2)c1,,CCOC(C)=O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20150133457A1,CN(c1ccc([N+](=O)[O-])cc1)[C@H]1CCN(CCS(C)(=O)=O)C1>>CN(c1ccc(N)cc1)[C@H]1CCN(CCS(C)(=O)=O)C1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20120232056A1,CC1CCCCN1.COC(=O)c1ccc2[nH]c(=O)c(Cl)nc2c1>>COC(=O)c1ccc2[nH]c(=O)c(N3CCCCC3C)nc2c1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US05374638,COC(=O)C(Br)c1cccc(Cl)c1.Cc1cc(C=O)cc(C)c1O>>COC(=O)C(Oc1c(C)cc(C=O)cc1C)c1cccc(Cl)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080171743A1,C[C@H]1COCCN1c1cc(CO)nc(-c2ccc(NC(=O)OC(C)(C)C)cc2)n1>>C[C@H]1COCCN1c1cc(CO)nc(-c2ccc(N)cc2)n1,,C1COCCO1,Cl,ClCCl,,val
US04200641,O=[N+]([O-])c1cc(Cl)c(Cl)cc1NCCCCl.c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>O=[N+]([O-])c1cc(Cl)c(Cl)cc1NCCCN1CCN(C(c2ccccc2)c2ccccc2)CC1,,CC(=O)CC(C)C,O,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20030017948A1,CCOC(=O)N(c1cc(N)c(F)cc1Br)S(=O)(=O)CC>>CCS(=O)(=O)Nc1cc(N)c(F)cc1Br,,O,,Cl,[Na+].[OH-],val
US20100010007A1,CC(=O)Cl.CSc1ccc(Cc2noc(C3CCN(C(=O)OC(C)(C)C)CC3)n2)cc1>>CSc1ccc(Cc2noc(C3CCNCC3)n2)cc1.Cl,,CO,,,,val
US20080318953A1,Cc1cc(N2CCOCC2)nc(C)c1N.Cc1cccc(CC(=O)O)c1>>Cc1cccc(CC(=O)Nc2c(C)cc(N3CCOCC3)nc2C)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20080171743A1,CNC(=O)CSCc1cc(N2CCOC[C@@H]2C)nc(-c2ccc(NC(=O)NC)cc2)n1.O=C(OO)c1cccc(Cl)c1.O=[Mn](=O)(=O)[O-]>>CNC(=O)CS(=O)(=O)Cc1cc(N2CCOC[C@@H]2C)nc(-c2ccc(NC(=O)NC)cc2)n1,,C1COCCO1,,O,,val
US20100204235A1,CNC(=O)c1cccc(C2=CC(Cl)NN=C2)c1.N>>CNC(=O)c1cccc(C2=CC(N)NN=C2)c1,,CCO,,,,val
US20040176446A1,N#CCc1cc(-c2ccc(F)cc2F)ccc1OCc1ccc(C2CCCCC2)cc1>>NCCc1cc(-c2ccc(F)cc2F)ccc1OCc1ccc(C2CCCCC2)cc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20130252941A1,O=P(Br)(Br)Br.[O-][n+]1cc(Cl)c2nn(-c3c(Cl)cccc3Cl)cc2c1>>Clc1cccc(Cl)c1-n1nc2c(Cl)cncc2c1Br,,ClCCCl,,,,val
US20040157866A1,CC(C)(C)C(=O)OCCl.O=C(O)c1ccc(-c2ccccc2C(=O)Nc2ccc3c(c2)CCN3C(=O)Cc2ccccn2)cc1>>CC(C)(C)C(=O)OCOC(=O)c1ccc(-c2ccccc2C(=O)Nc2ccc3c(c2)CCN3C(=O)Cc2ccccn2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05130312,COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCN)C[C@H]1OC.Clc1ncccn1>>CO[C@@H]1CN(CCCNc2ncccn2)CC[C@@H]1NC(=O)C1=CC(Cl)(OC)C(N)C=C1,,CC(=O)N(C)C,,O=C([O-])[O-].[Na+].[Na+],,val
US20020052384A1,N#Cc1cnc2[nH]c(N)nc(N)c1-2.O=CO>>Nc1nc(N)c2c(C=O)cnc-2[nH]1,[Ni],,,,,val
US20050054678A1,BrCc1ccccc1.CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](O)CC1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](OCc2ccccc2)CC1,,CS(C)=O,O,C1CCOC1,[H-].[Na+],val
US20130184460A1,Cl.Cn1cnc(C(=O)N(CC(=O)OC(C)(C)C)C2CCC2)c1>>Cl.Cn1cnc(C(=O)N(CC(=O)O)C2CCC2)c1,,CCOC(C)=O,,,,val
US20130131018A1,CCCCCBr.COc1cc(C=O)cc(OC)c1O>>CCCCCOc1c(OC)cc(C=O)cc1OC,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05314889,CC(=O)n1c(C(=O)O)cc2ccccc21.COc1sc(N)nc1-c1ccccc1>>COc1sc(NC(=O)c2cc3ccccc3[nH]2)nc1-c1ccccc1,,ClCCl,O,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US04822813,CC(=O)C(Cl)CCCl.CC(O)CS>>CC1=C(CCCl)SCC(C)O1,,Cc1ccccc1,,CCN(CC)CC,,val
US20080221180A1,CC(=O)Nc1nc(C)c(-c2ccc(S(=O)(=O)Cl)s2)s1.CNC>>CC(=O)Nc1nc(C)c(-c2ccc(S(=O)(=O)N(C)C)s2)s1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20090054407A1,CC(C)(N)c1ccccc1.COCOc1ccc(C(=O)O)cc1Cl>>COCOc1ccc(C(=O)NC(C)(C)c2ccccc2)cc1Cl,,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20150025087A1,Cc1ccc(C(F)(F)F)nc1CO.O=S(Cl)Cl>>Cc1ccc(C(F)(F)F)nc1CCl,,ClCCl,,,,val
US20030139441A1,CC(C)S(=O)(=O)Cl.Cc1nc2c(N)nc3ccccc3c2n1CCOCCN>>Cc1nc2c(N)nc3ccccc3c2n1CCOCCNS(=O)(=O)C(C)C,,c1ccncc1,,,,val
US20130190293A1,CNC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cn1.Cc1ccc2c(c1)c1c(n2-c2ccccc2Br)CCN(C)C1>>CNC(=O)c1ccc(-c2ccccc2-n2c3c(c4cc(C)ccc42)CN(C)CC3)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20110124634A1,CCN(CC)CCN.Nc1nc(Cl)c2c(n1)N(Cc1cccnc1)C(=O)/C2=C\c1cc(C(=O)O)c[nH]1>>CCN(CC)CCNC(=O)c1c[nH]c(/C=C2\C(=O)N(Cc3cccnc3)c3nc(N)nc(Cl)c32)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20130059849A1,CCOC(=O)c1cc(-c2ccccc2)nc2c1cnn2C(C)C.O=[N+]([O-])O>>CCOC(=O)c1cc(-c2ccccc2[N+](=O)[O-])nc2c1cnn2C(C)C,,O,,O=S(=O)(O)O,O=C([O-])[O-].[Na+].[Na+],val
US04536505,CCCOS(=O)(=O)c1ccccc1.CCOC(=O)CS.c1cncc(-n2ccc3ccccc32)c1>>CCOC(=O)CSCCCc1cn(-c2cccnc2)c2ccccc12,,CN(C)C=O,O,[H-].[Na+],,val
US04094840,CSC1=CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C.O=C(OC(=O)c1ccccc1)c1ccccc1>>C[C@]12C[C@H](O)[C@@]3(F)[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC=C2SCOC(=O)c1ccccc1,,Cc1ccccc1C,,C[O-].[Na+],,val
US20130150359A1,C=Cc1cc(-c2n[nH]c3cnc4cc(OC)c(OC)cc4c23)ccc1C#N.O=[O+][O-]>>COc1cc2ncc3[nH]nc(-c4ccc(C#N)c(CO)c4)c3c2cc1OC,,CCO,CN(C)C=O,C1CCOC1,[BH4-].[Na+],val
US20110150834A1,C=C(C)O[Si](C)(C)C.C[Si](C)(C)OC1=CCOCC1>>CC(=O)CC1COCCC1=O,,CC#N,,O,O=C([O-])O.[Na+],val
US05304549,CC(C)C[C@@H](N)C(=O)O.O=S(=O)(O)O>>CC(C)C[C@@H](O)C(=O)O,,O,O=S(=O)(O)O,O=N[O-].[Na+],,val
US20130225524A1,O=[N+]([O-])c1cc(Br)cc([N+](=O)[O-])c1.OB(O)C1=CCCC1>>O=[N+]([O-])c1cc(C2=CCCC2)cc([N+](=O)[O-])c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20150322073A1,CC(C)N1C(=O)C(C)(C)c2ccc(F)cc21.O=[N+]([O-])O>>CC(C)N1C(=O)C(C)(C)c2cc([N+](=O)[O-])c(F)cc21,,CC(=O)O,,O=S(=O)(O)O,,val
US05177087,CN(C)c1ccc(C2=CCN(Cc3ccccc3)CC2)cc1.Cl.Cl>>CN(C)c1ccc(C2CCNCC2)cc1.Cl.Cl,[Pd],CCO,O,,,val
US20070265265A1,Nc1nc(-c2ccc(C(=O)O)cc2)cs1.O=C(O)[C@@H]1CCCN1C(=O)OCc1ccccc1>>O=C(O)c1ccc(-c2csc(NC(=O)C3CCCN3C(=O)OCc3ccccc3)n2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140194469A1,CCOC(=O)/C(C)=C/NNc1cc(C#N)ccn1>>Cc1cnn(-c2cc(C#N)ccn2)c1O,,CCO,,CC(C)(C)[O-].[K+],,val
US20080004271A1,N#Cc1c(Cl)nc(NC2CC2)nc1-c1cccc([N+](=O)[O-])c1.NC(=O)CS>>N#Cc1c(SCC(N)=O)nc(NC2CC2)nc1-c1cccc([N+](=O)[O-])c1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20100190688A1,C=CCC(NC(=O)OC(C)(C)C)C(=O)N1C(C=C)CCC1C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NC1C=CCC2CCC(C(=O)OCc3ccccc3)N2C1=O,,ClCCl,,,,val
US06194410B1,CSc1nn2c(Cl)cc(C(C)C)nc2c1S(=O)(=O)c1ccccc1.N>>CSc1nn2c(N)cc(C(C)C)nc2c1S(=O)(=O)c1ccccc1,,CO,,,,val
US06437146B1,Nc1cccc(CC2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1.O=C=NC(=O)c1ccccc1>>O=C(NC(=O)c1ccccc1)Nc1cccc(CC2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1,,ClCCl,,CCCCCC,,val
US04529549,CC(C)(C)OC(=O)N[C@@H](COCc1ccccc1)C(=O)NCCCCN(CCCNC(=O)OCc1ccccc1)C(=O)OCc1ccccc1>>N[C@@H](COCc1ccccc1)C(=O)NCCCCN(CCCNC(=O)OCc1ccccc1)C(=O)OCc1ccccc1,,O=C(O)C(F)(F)F,,,,val
US20090143440A1,ClCl.O=C(O)c1cc(Cl)[nH]n1>>O=C(O)c1n[nH]c(Cl)c1Cl,,O,,,,val
US04367238,O=C(O)Cc1cccc(Oc2cccc(Cl)c2)c1O>>O=C1Cc2cccc(Oc3cccc(Cl)c3)c2O1,,CC(=O)OC(C)=O,,,,val
US20140107151A1,CCOC(=O)CC(=O)[C@@H]1CCCN(C(=O)OCc2ccccc2)C1.N#CC=C(N)c1ccc(Oc2ccccc2)cc1>>N#Cc1c(-c2ccccc2)[nH]c([C@@H]2CCCN(C(=O)OCc3ccccc3)C2)cc1=O,,CC(=O)N(C)C,O,CO,ClCCl,val
US20090137642A1,C1CCOC1.CCC(=O)Cl.CCO.N=C(NO)c1sc(N)nc1-c1ccccc1>>CCC(=O)Nc1nc(-c2ccccc2)c(-c2noc(CC)n2)s1,,C1CCOC1,CCO,CCN(C(C)C)C(C)C,Cl,val
US06258961B1,Br.NC(=O)C(NCCc1cccs1)c1ccccc1Cl>>Br.NC(=O)C(NCCc1cccs1)c1ccccc1Cl,,CC(C)=O,,,,val
US20110065766A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC12CC3CC(C1)C(O)C(C3)C2>>CC(C)(C)OC(=O)NCC12CC3CC(C1)C(O)C(C3)C2,,ClCCl,,CCN(CC)CC,Cl,val
US05145970,C=C(C)C(=O)OC.Cc1cc(S)cc(C(C)(C)C)c1N>>COC(=O)C(C)CSc1cc(C)c(N)c(C(C)(C)C)c1,,Cc1ccccc1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US05753664,CI.O=C(c1ccc(Cl)cc1)c1ccc(Cn2cnc3c(Cl)n[nH]c(=O)c32)cc1>>Cn1nc(Cl)c2ncn(Cc3ccc(C(=O)c4ccc(Cl)cc4)cc3)c2c1=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110269741A1,CC(C)[C@H](N)CO.CCOC(=O)/C(=C\N(C)C)C(=O)c1cc(Br)ccc1Br>>CCOC(=O)C(=CN[C@H](CO)C(C)C)C(=O)c1cc(Br)ccc1Br,,C1CCOC1,CCOC(C)=O,,,val
US04661592,CC(=O)OC(C)=O.O=c1c(CO)cnc2c3ccccc3ccn12>>CC(=O)O.O=c1c(CO)cnc2c3ccccc3ccn12,CN(C)c1ccncc1,ClC(Cl)Cl,,CCN(CC)CC,,val
US20100168080A1,C=O.O=C1COCCCN1Cc1ccccc1>>O=C1C(CO)OCCCN1Cc1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20070032518A1,CCc1cc(C(N)=S)ccn1.COC(=O)CC(=O)CCl>>CCc1cc(-c2nc(CC(=O)OC)cs2)ccn1,,CO,,,,val
US20050203079A1,C=CCC(C(=O)Nc1ccc(OC)c(OCCN2CCCCC2)c1)c1cccc(F)c1.O=[Os](=O)(=O)=O>>COc1ccc(N2C(=O)C(c3cccc(F)c3)CC2O)cc1OCCN1CCCCC1,O=[Os](=O)(=O)=O,O,,C1CCOC1,,val
US20010003782A1,CC(=O)OC(C)=O.C[C@H](CCCO)[C@H]1CC=C2C3=C(CC[C@@]21C)[C@@]1(C)CC[C@H](O[Si](C)(C)C(C)(C)C)C(C)(C)[C@@H]1CC3>>CC(=O)OCCC[C@@H](C)[C@H]1CC=C2C3=C(CC[C@@]21C)[C@@]1(C)CC[C@H](O)C(C)(C)[C@@H]1CC3,,c1ccncc1,,,,val
US06015774,CCCCOC(=O)COc1cc(F)c(-c2ncc(C(F)(F)F)n(C)c2=O)cc1[N+](=O)[O-]>>Cn1c(C(F)(F)F)cnc(-c2cc3c(cc2F)OCC(=O)N3)c1=O,[Fe],CC(=O)O,CCOC(C)=O,O,,val
US20030207865A1,CCc1cc(C#N)ccc1N.S=C(Cl)Cl>>CCc1cc(C#N)ccc1N=C=S,,Cc1ccccc1,,,,val
US20100298320A1,CC(C)(C)OC(=O)Nc1ccc(Oc2ccnc(N)c2[N+](=O)[O-])cc1>>CC(C)(C)OC(=O)Nc1ccc(Oc2ccnc(N)c2N)cc1,[Pd],CCO,,CCOC(C)=O,,val
US20140031388A1,CC(=O)CCCC(C)C.O=C(CO)c1ccccc1>>O=c1ccoc2ccccc12,,Cc1ccccc1,,C1CCNC1,,val
US20150031674A1,CSc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3C)c(=O)n(CCCCO)c2n1.O=C(OO)c1cccc(Cl)c1>>Cc1cccc(-c2ccc(-c3cc4cnc(S(C)=O)nc4n(CCCCO)c3=O)c(C)c2)n1,,ClCCl,,,,val
US20070037942A1,C=C(C)C(=O)NCc1ccccc1.C=C(C)C(=O)O.C=C(C)C(=O)O.C=C(C)C(=O)O.CCC(CO)(CO)CO>>C=C(C)C(=O)NCc1ccccc1.C=C(C)C(=O)OCC(CC)(COC(=O)C(=C)C)COC(=O)C(=C)C,,Cc1ccccc1,O,[Na],,val
US20060264460A1,N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(Cl)c1.NS(=O)(=O)c1ccc(C=O)cc1>>N#Cc1cnc2ccc(NCc3ccc(S(N)(=O)=O)cc3)cc2c1Nc1ccc(F)c(Cl)c1,,CCO,,[BH3-]C#N.[Na+],,val
US20090036436A1,O=Cc1ccnc(Cl)c1.[C-]#[N+]CC(=O)N1CCCC1>>O=C([C@@H]1N=CO[C@H]1c1ccnc(Cl)c1)N1CCCC1,,CO,,[K+].[OH-],,val
US20060211656A1,CC(C)(C)OC(=O)N[C@](C)(CCc1ccc(OCc2ccccc2)c([N+](=O)[O-])c1)COP(=O)(OC(C)(C)C)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@](C)(CCc1ccc(O)c(N)c1)COP(=O)(OC(C)(C)C)OC(C)(C)C,[Pd],CCO,,[H][H],,val
US20140142114A1,CC(C)(C)OC(=O)N1CCC(N)CC1.O=[N+]([O-])c1ccc(F)cc1C(F)(F)F>>CC(C)(C)OC(=O)N1CCC(Nc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)CC1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100197715A1,[N-]=[N+]=NC1(c2ccccc2)CCCN(C(=O)OCc2ccccc2)C1>>CN1CCCC(N)(c2ccccc2)C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050182258A1,CCCCO[C@@]12CCC(=O)[C@]3(Cc4ccccc4)Oc4c(O)ccc5c4[C@]13CCN(C)[C@@H]2C5.CI>>CCCCO[C@@]12CCC(=O)[C@]3(Cc4ccccc4)Oc4c(O)ccc5c4[C@]13CC[N+](C)(C)[C@@H]2C5.[I-],,O,,,,val
US04188328,CC(CCCC1(C)OCCO1)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C>>CC(=O)CCCC(C)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,CC(C)=O,,Cl,O=C([O-])O.[Na+],val
US20130150339A1,COc1cc(Cl)ccc1B(O)O.COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(Cl)nncc3c2)c(OC)c1>>COc1cc(Cl)ccc1-c1nncc2cc(S(=O)(=O)Nc3nccs3)ccc12,,O,,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20140135316A1,COC(=O)CCNc1cc(Br)ccc1N>>O=C1CCNc2cc(Br)ccc2N1,,CO,,[Na],,val
US20080262048A1,Nc1ccc(Cl)cc1C=O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=Cc1cc(Cl)ccc1NS(=O)(=O)C(F)(F)F,,ClCCl,ClCCl,CCN(CC)CC,,val
US20150080393A1,CCOC(=O)[C@@H]1CC2(CCNCC2)CN1C(=O)OCc1ccccc1.Nc1nc(Cl)cc(O[C@H](c2ccc(Br)cc2)C(F)(F)F)n1>>CCOC(=O)[C@@H]1CC2(CCN(c3cc(O[C@H](c4ccc(Br)cc4)C(F)(F)F)nc(N)n3)CC2)CN1C(=O)OCc1ccccc1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20050119325A1,COC(=O)CS.COc1cccc(C=O)c1[N+](=O)[O-]>>COC(=O)c1cc2cccc(OC)c2s1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160145247A1,COC(=O)Cc1ccccc1N.O=C(O)c1cccc(Br)c1>>COC(=O)Cc1ccccc1NC(=O)c1cccc(Br)c1,,CCOC(C)=O,CN(C)C=O,Cl,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130143888A1,COc1ccc(C2=C(c3ccc(O)cc3)C(=O)C(C)(C)O2)cc1.Cc1cccc2nc(CCl)cn12>>COc1ccc(C2=C(c3ccc(OCc4cn5c(C)cccc5n4)cc3)C(=O)C(C)(C)O2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150111846A1,CC(C)(C)OC(=O)N1CCC(C#N)CC1.ClCCCBr>>CC(C)(C)OC(=O)N1CCC(C#N)(CCCCl)CC1,,C1CCOC1,O,[Li]CCCC,[Cl-].[NH4+],val
US03984416,CCC1CCCC1CN.COC(N)=O>>CCC1CCCC1CNC(N)=O,,C1COCCO1,,N,,val
US20070015744A1,CI.CN(CCOc1cccc2c1[nH]c(=O)n2Cc1ccccc1)C(=O)OC(C)(C)C>>CN(CCOc1cccc2c1n(C)c(=O)n2Cc1ccccc1)C(=O)OC(C)(C)C,,CN(C)C=O,,O,[H-].[Na+],val
US20050043388A1,COC(=O)COc1ccc(-c2nn[nH]n2)cc1.NN>>NNC(=O)COc1ccc(-c2nnn[nH]2)cc1,,CO,,O,,val
US20090023702A1,C/C=C\B(O)O.Cc1cc(Br)ccc1OC(=O)N1CCC(Oc2ccn(-c3ccc(S(C)(=O)=O)cc3)c(=O)c2)CC1>>C/C=C\c1ccc(OC(=O)N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)cc4)c(=O)c3)CC2)c(C)c1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100273781A1,CS(=O)(=O)c1ccc(C(=O)O)cc1.Cc1cc(C)n(CC(=O)N2CCN(c3ncc(Cl)cc3N)CC2)n1>>Cc1cc(C)n(CC(=O)N2CCN(c3ncc(Cl)cc3NC(=O)c3ccc(S(C)(=O)=O)cc3)CC2)n1,CN(C)C=O,ClCCl,,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20070135479A1,CC(C)(C)OC(=O)N1CCCC(Sc2ccc3c(NC(=O)c4ccccc4)nccc3c2)C1>>Nc1nccc2cc(SC3CCCNC3)ccc12,,CO,,CC(=O)O,Cl,val
US20060079533A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OC1CNCCC1c1ccc(F)cc1>>CC(C)(C)OC(=O)N1CCC(c2ccc(F)cc2)C(O)C1,,CN(C)C=O,,CCN(CC)CC,,val
US20130035326A1,CC(C)(C)OC(=O)Nc1ccc(-c2ccc(NCCN3CCCCC3)nc2)cc1F>>Nc1ccc(-c2ccc(NCCN3CCCCC3)nc2)cc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US04766121,COc1ccc(OCc2ccccc2)cc1C=O>>COc1ccc(OCc2ccccc2)cc1CO,,CO,,[BH4-].[Na+],,val
US20100280030A1,Cc1ccc2oc(=O)n(Cc3cccc(-c4ncc(N5CCN(C(=O)OC(C)(C)C)CC5)cn4)c3)c2n1>>Cc1ccc2oc(=O)n(Cc3cccc(-c4ncc(N5CCNCC5)cn4)c3)c2n1,,C1COCCO1,CC#N,Cl,,val
US20120059028A1,C#CCBr.COC(=O)Cc1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCCC3>>C#CCC(C(=O)OC)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCCC3,,CN(C)C=O,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20050054631A1,C1CNCCN1.O=Cc1c(Cl)n(-c2ccccc2)c2ccccc12>>O=Cc1c(N2CCNCC2)n(-c2ccccc2)c2ccccc12,,O,,C1COCCO1,,val
US20100179216A1,CC1=NC(CCF)(CCc2ccc(OCCCc3cccc(C)c3)c(C(F)(F)F)c2)CO1.Cl>>Cc1cccc(CCCOc2ccc(CCC(N)(CO)CCF)cc2C(F)(F)F)c1.Cl,,CCO,,,,val
US20150099734A1,O=C(NCC1(CCl)CCN(C(=O)OCc2ccc(OC(F)(F)F)cc2)CC1)N1CCc2[nH]nnc2C1>>O=C(OCc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)CN(C(=O)N1CCc3[nH]nnc3C1)C2,,CN(C)C=O,,[H-].[Na+],,val
US20140350019A1,COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)OC(C)C)c1C>>COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C,,C1CCOC1,,[Li+].[OH-],,val
US20100137254A1,CCOC=O.CNCC(=O)OC>>COC(=O)CN(C)C=O,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20070066607A1,CCc1cc2c(cc1CC)CC(N)C2>>CCC1=C(CC)CC2=C(C1)CC(N)C2,,N,,[Li],,val
US20050158863A1,CCCCN.N#CC(=Cc1ccc(O)cc1)C(=O)O>>CCCCN.N#CC(=Cc1ccc(O)cc1)C(=O)O,,CO,,,,val
US20100216802A1,CC(C)(C)OC(=O)N[C@@H](CCN)C(=O)OC1CCCC1.CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)O)cc3OC)nc2N1C1CCCC1>>CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NCC[C@H](NC(=O)OC(C)(C)C)C(=O)OC4CCCC4)cc3OC)nc2N1C1CCCC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20150353553A1,C[C@@H](N)C1CCC1.Fc1cc(Cn2cnc3nc(I)nc(Cl)c32)ccc1Cl>>C[C@@H](Nc1nc(I)nc2ncn(Cc3ccc(Cl)c(F)c3)c12)C1CCC1,,CCO,CCOC(C)=O,CCN(C(C)C)C(C)C,Cl,val
US20060004017A1,COc1cc2c(Cl)ncnc2cc1OCCCN1CCOCC1.Oc1ccc2c(Cl)ccnc2c1>>COc1cc2c(Oc3ccc4c(Cl)ccnc4c3)ncnc2cc1OCCCN1CCOCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080096877A1,CN(C)C(=O)CN1CCNCC1.O=S(=O)(Nc1cccc2cc(-c3ncc(CCl)s3)[nH]c12)c1cccs1>>CN(C)C(=O)CN1CCN(Cc2cnc(-c3cc4cccc(NS(=O)(=O)c5cccs5)c4[nH]3)s2)CC1,,CN(C)C=O,,CCN(CC)CC,O,val
US20070015750A1,Br[Mg]Cc1ccccc1.COc1c(Cl)ccc2c1C(C)(C)CC(O)(C(F)(F)F)C2=O>>COc1c(Cl)ccc2c1C(C)(C)CC(O)(C(F)(F)F)C2(O)Cc1ccccc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20120101136A1,CCc1cc(OCCCBr)ccc1-c1noc(-c2ccc(OC(C)C)c(Cl)c2)n1.CN>>CCc1cc(OCCCNC)ccc1-c1noc(-c2ccc(OC(C)C)c(Cl)c2)n1,,C1CCOC1,,,,val
US20150141400A1,CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(C=O)c(C(F)(F)F)cc2c1=O.CN(C[C@@H]1CCCN1)C(=O)OC(C)(C)C>>CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(CN3CCC[C@H]3CN(C)C(=O)OC(C)(C)C)c(C(F)(F)F)cc2c1=O,,ClC(Cl)Cl,,,,val
US20150376136A1,C=CCBr.CC1(C2CCCCC2)NC(=O)NC1=O>>C=CCN1C(=O)NC(C)(C2CCCCC2)C1=O,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20140163012A1,Cl.O=c1cc(OCc2cccc(C(F)(F)F)n2)ccn1-c1ccc2c3c(oc2c1)CCCNC3>>Cl.O=c1cc(OCc2cccc(C(F)(F)F)n2)ccn1-c1ccc2c3c(oc2c1)CCCNC3,,CO,,CCOCC,,val
US04965270,COCO[C@H](CCOCc1ccccc1)COCc1ccccc1>>O[C@H](CCOCc1ccccc1)COCc1ccccc1,,CCO,,,,val
US20040077638A1,COC(=O)CC1c2ccccc2C(=O)N(C)c2cc(C(=O)O)ccc21.NCCCCNc1nc2ccccc2[nH]1>>COC(=O)CC1c2ccccc2C(=O)N(C)c2cc(C(=O)NCCCCNc3nc4ccccc4[nH]3)ccc21,,CCOC(C)=O,CO,O=C(O)C(F)(F)F,,val
US20090131457A1,Cn1nc(Br)c2c(Cl)nc(N)nc21.NCc1ccccc1>>Cn1nc(Br)c2c(NCc3ccccc3)nc(N)nc21,,CN(C)C=O,,,,val
US20020045747A1,N.O=Cc1cccc(-c2ccccc2)c1>>NCc1cccc(-c2ccccc2)c1,,CO,,,,val
US20020052028A1,CC=C[C@@H](O)[C@H](C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](C)CO.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CC=C[C@@H](O)[C@H](C)[C@H](O[Si](C)(C)C(C)(C)C)[C@H](C)COC(c1ccccc1)(c1ccccc1)c1ccccc1,,c1ccncc1,,,,val
US20080032968A1,COc1ccc2[nH]ccc2c1CN(C)C.O=S(=O)(Cl)c1cccnc1>>COc1ccc2c(ccn2S(=O)(=O)c2cccnc2)c1CN(C)C,,ClCCl,,Cl,,val
US04940710,CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)cc21.Cn1ccc(C2CNCCN2)n1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(c4ccn(C)n4)C3)cc21,,c1ccncc1,,,,val
US20020006944A1,CCOC(=O)COc1cccc2c1CCc1sc(S)nc1-2.ICC(c1ccccc1)c1ccccc1>>CCOC(=O)COc1cccc2c1CCc1sc(SCC(c3ccccc3)c3ccccc3)nc1-2,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20020052376A1,CC(C)(C)OC(=O)[C@H](CCS(C)(=O)=O)NC(=O)c1ccc(OC(Cn2ccnc2)c2ccc(F)cc2)cc1-c1ccc(F)cc1>>CS(=O)(=O)CCC(NC(=O)c1ccc(OC(Cn2ccnc2)c2ccc(F)cc2)cc1-c1ccc(F)cc1)C(=O)O,,O=C(O)C(F)(F)F,,,,val
US05371101,C[C@@H](n1ncn(-c2ccc(N3CCN(Cc4ccccc4)CC3)cc2)c1=O)[C@](O)(Cn1cncn1)c1ccc(F)cc1F>>C[C@@H](n1ncn(-c2ccc(N3CCNCC3)cc2)c1=O)[C@](O)(Cn1cncn1)c1ccc(F)cc1F,[Pd],CCO,,[H][H],,val
US20060148858A1,BrCc1ccccc1.CCOC(=O)c1c[nH]nc1C(CC)CC>>CCOC(=O)c1cn(Cc2ccccc2)nc1C(CC)CC,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20110172297A1,O=C1CCC(=NO)C(c2ccc(Br)cc2)N1>>N[C@@H]1CCC(=O)N[C@@H]1c1ccc(Br)cc1,[Ni],CCO,,,,val
US20100056515A1,CCOC(=O)Cn1c(=O)n(C(=O)OC(C)(C)C)c2cccc(C(CC)CC)c21>>CCOC(=O)Cn1c(=O)[nH]c2cccc(C(CC)CC)c21,,CCOC(C)=O,,Cl,O=C([O-])O.[Na+],val
US20070213371A1,CC(C)(C)[Si](C)(C)OCc1cc(C(F)(F)F)ccc1Br.O=C1CCCCC1>>CC(C)(C)[Si](C)(C)OCc1cc(C(F)(F)F)ccc1C1(O)CCCCC1,,C1CCOC1,,[Li]CCCC,,val
US05763450,CC1=CC(C(C)(C)C)=C(O)C(C)(C(C)(C)C)C1.CCOC(=O)c1cn(C2CCCCC2)c2cc(Br)ccc2c1=O>>C=Cc1ccc2c(=O)c(C(=O)OCC)cn(C3CCCCC3)c2c1,,Cc1ccccc1,,CCOC(C)=O,,val
US20140066625A1,CC(=O)c1ccccc1I.O=CC1CCCCC1>>O=C(CC(O)C1CCCCC1)c1ccccc1I,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US06429200B1,CCCCCCCCCCCCS.O=S(=O)(Cl)Cl>>CCCCCCCCCCCCSCl,,ClC(Cl)Cl,,,,val
US06627651B1,CCCOCCOc1ccc(OB(O)O)cc1.COC(=O)C1=Cc2cc(O)ccc2S(=O)(=O)CC1>>CCCOCCOc1ccc(Oc2ccc3c(c2)C=C(C(=O)OC)CCS3(=O)=O)cc1,,ClCCl,,CCN(CC)CC,,val
US04826866,CCOC(=O)C(Cl)C(C)=O.CN(C)C(=S)NN>>CCOC(=O)c1c(N(C)C)n[nH]c1C.Cl,,CCO,,c1ccccc1,,val
US20090143355A1,N#Cc1ccnc(Cl)c1.c1ccncc1>>N#Cc1ccnc(N)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US20090306066A1,O=CN(C[C@@H](CC1CCCC1)C(=O)NNc1nc(Cl)nc(NCc2cscn2)c1F)OC1CCCCO1>>O=CN(O)C[C@@H](CC1CCCC1)C(=O)NNc1nc(Cl)nc(NCc2cscn2)c1F,,CC(=O)O,O,,,val
US20160039808A1,CCCO.Oc1nc(Cl)nc2cnccc12>>CCCOc1nc2cnccc2c(=O)[nH]1,,CCCO,,,,val
US20110021500A1,CCOC(=O)c1cc(Nc2ccc3c(c2)CC2(C3)C(=O)NC(=O)N2C)ncn1>>CN1C(=O)NC(=O)C12Cc1ccc(Nc3cc(C(=O)O)ncn3)cc1C2,,CCO,,Cl,[Na+].[OH-],val
US20120142705A1,CC(C)CC(C(=O)O)N1C(=O)C(=O)c2ccc(Cl)cc21.Nc1ccccn1>>CC(C)CC(C(=O)Nc1ccccn1)N1C(=O)C(=O)c2ccc(Cl)cc21,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20150266900A1,CN.NS(=O)(=O)c1c(F)c(F)c(S(=O)(=O)CCc2ccccc2)c(F)c1F>>CNc1c(F)c(S(N)(=O)=O)c(F)c(F)c1S(=O)(=O)CCc1ccccc1,,CO,,,,val
US20080176870A1,COC(=O)c1cc(O)n2nccc2n1>>O=C(O)c1cc(O)n2nccc2n1,,C1COCCO1,,[Na+].[OH-],,val
US20120295884A1,CNC(=O)c1cc(Cl)c(F)c(CNC(=O)OC(C)(C)C)c1>>CNC(=O)c1cc(Cl)c(F)c(CN)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040014802A1,CCCC(=O)Nc1n[nH]c2cc(-c3ccc(OCc4ccccc4)cc3)c(-c3ccc(OCc4ccccc4)cc3)cc12>>CCCC(=O)Nc1n[nH]c2cc(-c3ccc(O)cc3)c(-c3ccc(O)cc3)cc12,,CO,,C[Si](C)(C)I,,val
US20150166539A1,CN.O=Cc1cnc2ccc(Cl)nc2c1Nc1cccc(C(F)(F)F)c1>>CNCc1cnc2ccc(Cl)nc2c1Nc1cccc(C(F)(F)F)c1,,CCO,,[BH4-].[Na+],,val
US20100216860A1,CC(C)N=C=O.COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1>>COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)NC(C)C)c1,,CO,ClCCl,CCN(CC)CC,Cl,val
US20160264567A1,C[Sn](C)(C)[Sn](C)(C)C.FC(F)(F)c1cnc(Cl)cn1>>C[Sn](C)(C)c1cnc(C(F)(F)F)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20150118601A1,CC(=O)c1ccc(Br)cc1.O=Cc1ccccc1>>O=C(/C=C/c1ccccc1)c1ccc(Br)cc1,,CO,,CC(=O)O,[Na+].[OH-],val
US20160052884A1,CCOC(=O)c1ccc(NC(=O)C(CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)n2cc(OC)c(-c3cc(Cl)ccc3C#N)cc2=O)cc1>>COc1cn(C(CCO)C(=O)Nc2ccc(C(=O)O)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N,,CO,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040048858A1,CC(=O)c1ccc(C(=O)O)cc1.O=Cc1ccc(F)c(-c2cccs2)c1>>O=C(O)c1ccc(C(=O)/C=C/c2ccc(F)c(-c3cccs3)c2)cc1,,CN(C)C=O,O,[Na+].[OH-],,val
US20090264401A1,CC(=N)N.COC(=O)/C(=C\N(C)C)C(=O)C1CC(F)(F)C1>>COC(=O)c1cnc(C)nc1C1CC(F)(F)C1,,CO,,Cl,C[O-].[Na+],val
US20160158207A1,CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCNCC2)C1.O=S(=O)(OCC(F)F)C(F)(F)F>>CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCN(CC(F)F)CC2)C1,,CC#N,,CCN(CC)CC,,val
US20060287297A1,COC(=O)c1cccc2c(=O)c3ccccc3oc12>>O=C(O)c1cccc2c(=O)c3ccccc3oc12,,CO,,[Na+].[OH-],,val
US04067993,CCOC(=O)CNC(=O)c1cccc2c(-c3ccccc3)c([N+](=O)[O-])oc12>>O=C(O)CNC(=O)c1cccc2c(-c3ccccc3)c([N+](=O)[O-])oc12,,[Na+],[OH-],,,val
US20090054484A1,N#CCOc1cc(C(F)(F)F)nc2ccc(-c3cc4ccccc4o3)cc12.[N-]=[N+]=[N-]>>FC(F)(F)c1cc(OCc2nnn[nH]2)c2cc(-c3cc4ccccc4o3)ccc2n1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20160002259A1,Cc1c([C@@H]2CN3CCN(C(=O)OCc4ccccc4)C[C@H]3CN2C(=O)OC(C)(C)C)ccc2c1COC2=O>>Cc1c([C@@H]2CN3CCNC[C@H]3CN2C(=O)OC(C)(C)C)ccc2c1COC2=O,[Pd],CO,,,,val
US04801593,S=C1CC(c2ccccc2)Oc2ccccc21>>c1ccc(C2CCc3ccccc3S2)cc1,[Zn],CC(=O)O,,Cl,,val
US20090253687A1,CCCC(Br)C(=O)c1ccc2c(c1)NC(=O)CO2.Nn1cnnc1S>>CCCC1Sc2nncn2N=C1c1ccc2c(c1)NC(=O)CO2,,Cc1ccccc1,,CCO,,val
US20050027129A1,CC(=O)Cl.COc1ccc(C(=O)NCc2ccccc2)c2c1oc1ccc(N)cc12>>COc1ccc(C(=O)NCc2ccccc2)c2c1oc1ccc(NC(C)=O)cc12,,C1CCOC1,,c1ccncc1,,val
US06288051B1,C1=COCCC1.C1CCOC1.CC(=O)OCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3O)[C@@H]21.CCOC(C)=O>>CC(=O)OCCCCC[C@@H]1Cc2cc(OC3CCCCO3)ccc2[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3OC3CCCCO3)[C@@H]21,,C1CCOC1,CCOC(C)=O,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US04766233,CCOC(=O)CBr.Cn1c(=O)cnn(-c2cc(O)c(Cl)cc2Cl)c1=O>>CCOC(=O)COc1cc(-n2ncc(=O)n(C)c2=O)c(Cl)cc1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080153836A1,COC(=O)c1cc(-c2cccn2C)c(C(F)(F)F)cc1NC(=O)Oc1ccc(Cl)cc1.CS(=O)(=O)NN>>Cn1cccc1-c1cc2c(=O)n(NS(C)(=O)=O)c(=O)[nH]c2cc1C(F)(F)F,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20110046169A1,CCc1ccc(C#N)c(=O)n1-c1ccccc1.O=S(=O)(O)O>>CCc1ccc(C(=O)O)c(=O)n1-c1ccccc1,,O=S(=O)(O)O,,O,[Na+].[OH-],val
US20100004280A1,CC(=CC(=O)OCc1ccccc1)C(F)(F)F>>CC(=CCO)C(F)(F)F,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110118235A1,CCCN(CCC)C(=O)C1=Cc2ccc(-c3ccc(C(=O)N4CC[C@@H](O[Si](C)(C)C(C)(C)C)C4)cc3)cc2N=C(NC(=O)OC(C)(C)C)C1>>CCCN(CCC)C(=O)C1=Cc2ccc(-c3ccc(C(=O)N4CC[C@@H](O)C4)cc3)cc2N=C(NC(=O)OC(C)(C)C)C1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05047593,CC(=O)C(C)Cl.CC(C)(C)c1cc(S)cc(C(C)(C)C)c1O>>CC(=O)C(C)Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,,CCOCC,,CCN(CC)CC,,val
US20070270422A1,COc1ccc(NC(=O)NCCCl)cc1>>COc1ccc(N2CCNC2=O)cc1,,CC(C)(C)O,,Cl,CC(C)(C)[O-].[K+],val
US20070099955A1,Cc1ccc2c(c1OC(C)C)C[C@@H](C1CCN(CCc3ccccc3)CC1)O[C@H]2CNC=O>>CNC[C@@H]1O[C@H](C2CCN(CCc3ccccc3)CC2)Cc2c1ccc(C)c2OC(C)C,,C1CCOC1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20090318562A1,CC(Br)C(=O)c1cccc(Cl)c1.CC(C)(C)N>>CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1,,CC#N,,CCCCCC,CCOC(C)=O,val
US20040102509A1,C1COCCN1.C=O.O=C1Nc2ccccc2C1=CNc1ccc(N2CCOCC2)cc1>>O=C1C(=CNc2ccc(N3CCOCC3)cc2)c2ccccc2N1CN1CCOCC1,,CCO,,,,val
US20140194431A1,CC(C)(C)[Si](C)(C)OCCN(CC1CC1)C(=O)c1nc(CC2(c3ccc(Cl)cc3)CCCC2)nc(O)c1OCc1ccccc1>>O=C(c1nc(CC2(c3ccc(Cl)cc3)CCCC2)nc(O)c1OCc1ccccc1)N(CCO)CC1CC1,,C1CCOC1,,CCOC(C)=O,Cl,val
US20110178041A1,COc1ccc(Br)c2c1OCN(CO)C2=O>>COc1ccc(Br)c2c1OCNC2=O,,Cc1ccccc1,,,,val
US20130096121A1,CC1(C)CCCC(=O)C1.C[Si](C)(C)C1SCCCS1>>CC1(C)CCCC(=C2SCCCS2)C1,,C1CCOC1,CCOCC,[Li]CCCC,,val
US20110098296A1,CCC(N)=S.O=C(Cc1ccnc(Cl)n1)c1cccc(NC(=O)c2c(F)cccc2F)c1>>CCc1nc(-c2cccc(NC(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Cl)n2)s1,,CCOC(C)=O,CN(C)C=O,O=C1CCC(=O)N1Br,,val
US20150158865A1,CCOC(=O)N1CCC(C)(c2ccc(Br)cc2)CC1>>CC1(c2ccc(Br)cc2)CCNCC1,,CCO,,[K+].[OH-],,val
US20080003214A1,CCOC(=O)CCl.OCCNc1ccccc1>>O=C1COCCN1c1ccccc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US05608056,C=CCOC(=O)C1=C(S[C@H]2C[C@@H](CCn3cncc3CO)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12.CI>>C=CCOC(=O)C1=C(S[C@H]2C[C@@H](CC[n+]3cn(C)cc3CO)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12.[I-],,CC(C)=O,,,,val
US20150005283A1,COC(=O)[C@@H]1C[C@H](N)CN1CC1CCCCC1.O=C(O)c1ccc2ccccc2c1O>>COC(=O)[C@@H]1C[C@H](NC(=O)c2ccc3ccccc3c2O)CN1CC1CCCCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160168119A1,Cc1nnn(Cc2cc(C(F)(F)F)ccc2/C=C/C(=O)N(C)CC2CCN(C(=O)OC(C)(C)C)CC2)n1.Cl>>Cc1nnn(Cc2cc(C(F)(F)F)ccc2/C=C/C(=O)N(C)CC2CCNCC2)n1.Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020103192A1,COC(=O)CCCBr.Oc1ccc(-c2ccccc2)cc1>>COC(=O)CCCOc1ccc(-c2ccccc2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020137672A1,CCOC(=O)C(F)(F)F.COC(=O)CCCCCN>>COC(=O)CCCCCNC(=O)C(F)(F)F,,CO,,CCN(CC)CC,Cl,val
US20150274777A1,C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)C(=O)NCc1ccccc1>>C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCc1ccccc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20110118283A1,CC(C)(C)CC1NC(C(=O)NCC[C@H]2COC(C)(C)O2)C(c2cccc(Cl)c2F)C1(C#N)c1ncc(Cl)cc1F>>CC(C)(C)CC1NC(C(=O)NCC[C@H](O)CO)C(c2cccc(Cl)c2F)C1(C#N)c1ncc(Cl)cc1F,,C1CCOC1,,Cl,,val
US20140220573A1,O=c1ccn2c(n1)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]12.OCc1ccc2ccc3cccc4ccc1c2c34>>O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2OCc2ccc3ccc4cccc5ccc2c3c45)c(=O)[nH]1,,CS(C)=O,,C1CCOC1,O=C([O-])O.[Na+],val
US20080009530A1,CCOC(=O)c1cc(-c2ccccc2)n[nH]1.ClCc1ccc(Cl)cc1Cl>>CCOC(=O)c1cc(-c2ccccc2)nn1Cc1ccc(Cl)cc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04628059,COc1c(F)cc(CN)cc1F.S=C(Cl)Cl>>COc1c(F)cc(CN=C=S)cc1F,,C1CCOC1,,CCN(CC)CC,,val
US20050080124A1,CN(C)CCCOc1ccc(N)cc1-c1ccnn1C.O=C=Nc1ccccc1F>>CN(C)CCCOc1ccc(NC(=O)Nc2ccccc2F)cc1-c1ccnn1C,,ClCCl,,,,val
US20140296272A1,CCCC(C(=O)OC)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCOC3>>CCCC(C(=O)O)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCOC3,,CO,,[Na+].[OH-],,val
US20100113444A1,BrCCC1CCCCC1.CCOC(=O)CNC(=O)c1c(O)n(C2CCCCC2)c(=O)[nH]c1=O>>O=C(O)CNC(=O)c1c(O)n(C2CCCCC2)c(=O)n(CCC2CCCCC2)c1=O,,CC(=O)N(C)C,,Cl,O=C([O-])[O-].[K+].[K+],val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1.Cl>>Cc1cc(C(=O)NC2CCN(C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1.Cl,,C1COCCO1,,O=C(O)C(F)(F)F,,val
US20140135336A1,CSc1cc(-c2cn(C)nc2Cc2ccccc2)nn2c(C)nnc12.O=S(=O)(Cl)Cl>>Cc1nnc2c(Cl)cc(-c3cn(C)nc3Cc3ccccc3)nn12,,ClC(Cl)Cl,,,,val
US20120101136A1,CCc1cc(O)ccc1C#N.C[Si](C)(C)CCOCCl>>CCc1cc(OCOCC[Si](C)(C)C)ccc1C#N,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04785012,CCCCCCCCCCCCCC(=O)OC(c1cnco1)c1nc(C(CC(O[Si](C)(C)CCCC)C(O[Si](C)(C)CCCC)C(C)O[Si](C)(C)CCCC)O[Si](C)(C)CCCC)co1>>CCCCCCCCCCCCCC(=O)OC(c1cnco1)c1nc(C(O)CC(O)C(O)C(C)O)co1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100184815A1,CC(C)(C)OC(=O)C(C)(C)Sc1ccc(C(=O)O)cc1.OCc1cn(Cc2ccccc2)nn1>>CC(C)(C)OC(=O)C(C)(C)Sc1ccc(C(=O)OCc2cn(Cc3ccccc3)nn2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20080293768A1,COc1ccc(I)nc1.N#Cc1ccc(B(O)O)cc1>>COc1ccc(-c2ccc(C#N)cc2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,Cc1ccccc1,[Cl-].[Na+],O=C([O-])[O-].[Li+],val
US20070197588A1,CC=O.O=C1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21>>C/C=C1\C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc2C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US04161594,CC1(C)NC(=O)NC1=O.CC1CO1.CN(C)C=O>>CC(O)CN1C(=O)N(CC(C)O)C(C)(C)C1=O,,CN(C)C=O,,[Cl-].[Li+],,val
US04061641,NC1CCN(CCc2c[nH]c3ccccc23)CC1.S=C=Nc1ccccc1>>S=C(Nc1ccccc1)NC1CCN(CCc2c[nH]c3ccccc23)CC1,,c1ccccc1,,O,,val
US20020151547A1,Clc1ccc([C@H]2CCNC[C@H]2c2ccccc2)cc1Cl.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](c2ccc(Cl)c(Cl)c2)[C@H](c2ccccc2)C1,,ClCCl,O,CCN(CC)CC,Cl,val
US20060142265A1,BrBr.O=C1CNc2ncccc2CN1>>O=C1CNc2ncc(Br)cc2CN1,,CCCCCC,,CC(=O)O,,val
US20070197506A1,CC(C)C=O.O=C1N(c2ccccc2Cl)CCC12CCCN2>>CC(C)CN1CCCC12CCN(c1ccccc1Cl)C2=O,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140005222A1,COC(=O)c1cc(C)c(NC(=O)c2nc(N3CCCC(CO)C3)ccc2C)c(C)c1>>Cc1ccc(N2CCCC(CO)C2)nc1C(=O)Nc1c(C)cc(C(=O)O)cc1C,,C1CCOC1,,CO,[Na+].[OH-],val
US20050119260A1,CCCCI.Oc1cccc2cc[nH]c12>>CCCCOc1cccc2cc[nH]c12,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100240708A1,CCN(CC)S(F)(F)F.O=S(=O)(c1ccc(Cl)cc1)N(Cc1ccc(-c2ncco2)cc1F)[C@@H]1CCCC[C@H]1CO>>O=S(=O)(c1ccc(Cl)cc1)N(Cc1ccc(-c2ncco2)cc1F)[C@@H]1CCCC[C@H]1CF,,ClCCl,,,,val
US20100298339A1,NCc1cccc(-c2cccc3nc(Nc4ccc(OCCN5CCCC5)cc4)nn23)c1.O=C=Nc1cccc(Cl)c1>>O=C(NCc1cccc(-c2cccc3nc(Nc4ccc(OCCN5CCCC5)cc4)nn23)c1)Nc1cccc(Cl)c1,,ClCCl,,,,val
US05380718,CCOC(=O)C1=NN(c2cccc(Cl)c2)C(c2ccccc2)CC1>>O=C(O)C1=NN(c2cccc(Cl)c2)C(c2ccccc2)CC1,,O,,CO,[Na+].[OH-],val
US20140329798A1,CCOCc1cnc(Cl)nc1.OCC[C@@H]1C[C@@H]1C1CCNCC1>>CCOCc1cnc(N2CCC([C@H]3C[C@H]3CCO)CC2)nc1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050085541A1,COc1ccc(Oc2c(C)cc([N+](=O)[O-])c3c2CCC3)cc1.O=C(Cl)c1ccc(F)cc1>>COc1ccc(Oc2c(C)cc([N+](=O)[O-])c3c2CCC3)cc1C(=O)c1ccc(F)cc1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20070249688A1,CC(C)CC(Sc1ccc(Br)cc1)c1ccc(C(=O)O)cc1.COC(=O)CCN>>COC(=O)CCNC(=O)c1ccc(C(CC(C)C)Sc2ccc(Br)cc2)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US04332813,COC(=O)[C@](Cc1c[nH]c(C(C)O)n1)(N=Cc1ccccc1)C(c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)[C@](Cc1c[nH]c(C(C)OS(=O)(=O)c2ccc(C)cc2)n1)(N=Cc1ccccc1)C(c1ccccc1)(c1ccccc1)c1ccccc1,,c1ccncc1,,,,val
US06248755B1,CC(C)(C)OC(=O)N1CCC(c2cnc(C(=O)c3ccccc3)s2)CC1>>O=C(c1ccccc1)c1ncc(C2CCNCC2)s1,,CO,,Cl,,val
US20060116393A1,C1COCCN1.COC(=O)COc1c(OC)ccc2c1CCN1C[C@H](c3cccc(C)c3)/C(=N/OCc3ccccc3)C[C@@H]21>>COc1ccc2c(c1OCC(=O)N1CCOCC1)CCN1CC(c3cccc(C)c3)C(=NOCc3ccccc3)CC21,,Cc1ccccc1,,C[Al](C)C,,val
US20070112016A1,BrCCOC1CCCCO1.Cc1ccc2c(c1)C1(CCNCC1)C(=O)N2>>Cc1ccc2c(c1)C1(CCNCC1)C(=O)N2CCOC1CCCCO1,,CN(C)C=O,,[H-].[Na+],,val
US20070254925A1,O=Cc1nc(NC(=O)c2c(F)cccc2F)sc1-c1cccc(C(F)(F)F)c1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>O=C(Nc1nc(-c2cnco2)c(-c2cccc(C(F)(F)F)c2)s1)c1c(F)cccc1F,,CCOC(C)=O,CO,O=C([O-])[O-].[K+].[K+],,val
US20070249642A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cl.O=c1ccn(CCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)c(=O)[nH]1>>Cl.O=c1[nH]c(=S)ccn1CCCCN1C[C@@H]2C[C@]2(c2ccc(C(F)(F)F)cc2)C1,,COCCOC,,,,val
US05994368,COC(=O)/C=C/c1ccc(N)nc1.O=C(Cl)CCCBr>>COC(=O)/C=C/c1ccc(NC(=O)CCCBr)nc1,,ClCCl,,CCN(CC)CC,O,val
US20150166527A1,CO[C@H]1C[C@@H](C(=O)Nc2ccc(Cl)c(C)c2N)N(C(=O)OC(C)(C)C)C1>>CO[C@H]1C[C@@H](c2nc3ccc(Cl)c(C)c3[nH]2)N(C(=O)OC(C)(C)C)C1,,Cc1ccccc1,,CC(=O)O,,val
US20120179089A1,Brc1ccc(-c2nc3ccccc3s2)nc1.CC1(C)OB(c2ccc(-c3ccc(-n4c5ccccc5c5ccccc54)cc3)nc2)OC1(C)C>>c1ccc2sc(-c3ccc(-c4ccc(-c5ccc(-n6c7ccccc7c7ccccc76)cc5)nc4)cn3)nc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,O,O=C([O-])[O-].[Na+].[Na+],val
US05990102,BrBr.CC(=O)CCCCCCCc1ccccc1>>O=C(CBr)CCCCCCCc1ccccc1,,CCOCC,CO,O,,val
US05616610,CCCN(C1CCCCC1)[C@H]1COc2c(F)ccc(O)c2C1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCCN(C1CCCCC1)[C@H]1COc2c(F)ccc(OS(=O)(=O)C(F)(F)F)c2C1,,CCOCC,,CCN(CC)CC,O,val
US20030199550A1,CN(CC[C@@H]1CC[C@@H](/C=C/CCl)CC1)C(=O)Oc1ccc(Cl)cc1.CNC>>CN(C)C/C=C/[C@@H]1CC[C@@H](CCN(C)C(=O)Oc2ccc(Cl)cc2)CC1,,CC(=O)N(C)C,,,,val
US20080269305A1,CCCBr.Cc1ccc(C#N)c(=O)[nH]1>>CCCCc1ccc(C#N)c(=O)[nH]1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20060094767A1,CC1(Cn2nc(-c3ccc(OC(F)(F)F)cc3)oc2=O)CO1.O=[N+]([O-])c1c[nH]c(Cl)n1>>CC(O)(Cn1cc([N+](=O)[O-])nc1Cl)Cn1nc(-c2ccc(OC(F)(F)F)cc2)oc1=O,,CCO,,O,O=C([O-])O.[Na+],val
US20160175284A1,COC(=O)c1c(OC)ccc(OC)c1F>>COc1ccc(OC)c(C(=O)O)c1F,,CO,,,,val
US20100261679A1,CC(N)c1nccs1.CNC(=O)c1cc(Oc2ccc3nc(S(C)(=O)=O)ncc3c2)ccn1>>CNC(=O)c1cc(Oc2ccc3nc(NC(C)c4nccs4)ncc3c2)ccn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050075394A1,CC1(C)OCc2cc([C@@H]3CN(CCCCCCOCCO)C(=O)O3)ccc2O1.CS(=O)(=O)Cl>>CC1(C)OCc2cc([C@@H]3CN(CCCCCCOCCOS(C)(=O)=O)C(=O)O3)ccc2O1,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20050032871A1,COc1ccc2c(c1)CC(=O)N2.Cc1[nH]c(C=O)c(CCC(=O)O)c1S(=O)(=O)c1ccc(Cl)cc1>>COc1ccc2c(c1)/C(=C/c1[nH]c(C)c(S(=O)(=O)c3ccc(Cl)cc3)c1CCC(=O)O)C(=O)N2,,CCO,,C1CCNCC1,,val
US20130317207A1,CCN1CCC=C(C)c2ccc(O)cc21>>CCN1CCCC(C)c2ccc(O)cc21,[Pd],CO,,,,val
US20110306626A1,CCOC(=O)CN1C(=O)C(c2ccccc2)=NC12CCCCC2>>O=C(O)CN1C(=O)C(c2ccccc2)=NC12CCCCC2,,CO,O,[Na+].[OH-],,val
US20100286225A1,CCN(CC)/[N+]([O-])=N/OCOC(=O)c1ccc(CN(C(=O)OC(C)(C)C)S(=O)(=O)c2cc(C(=O)NN3c4ccccc4C[C@H]3C)ccc2Cl)cc1>>CCN(CC)/[N+]([O-])=N/OCOC(=O)c1ccc(CNS(=O)(=O)c2cc(C(=O)NN3c4ccccc4C[C@H]3C)ccc2Cl)cc1,,C1COCCO1,Cl,,,val
US20040014962A1,CN1CCN(C(=O)c2csc(N3CC(O[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)C3)n2)CC1>>CN1CCN(C(=O)c2csc(N3CC(O)C3)n2)CC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100331293A1,CCI.Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1>>CCN(c1cncc(N2CCOCC2)c1)c1c(C)c(-c2ccccn2)nc2cc(F)cc(F)c12,,CN(C)C=O,,[H-].[Na+],,val
US20070173519A1,CC(=O)OC(C)=O.CCOc1ccc(Nc2c3c(nc4ccnn24)N(O)CC3)cc1>>CCOc1ccc(Nc2c3c(nc4ccnn24)N(OC(C)=O)CC3)cc1,,CCN(CC)CC,,ClCCl,,val
US04611080,C=C(Cl)Cl.O=C(Cl)c1cc(F)c(F)cc1F>>O=C(C=C(Cl)Cl)c1cc(F)c(F)cc1F,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US05990105,CNC.Nc1ccc(S(=O)(=O)c2cc(Br)nc(Br)c2)cc1>>CN(C)c1cc(S(=O)(=O)c2ccc(N)cc2)cc(Br)n1,,C1COCCO1,CCO,,,val
US20120225867A1,CCOC(=O)c1ccc(-c2cnccc2C)s1>>Cc1ccncc1-c1ccc(C(=O)O)s1,,CCO,,[Na+].[OH-],,val
US06071928,CNc1ccc(OC)c(Br)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COc1ccc(CNC(=O)C(F)(F)F)cc1Br,,ClCCl,,CCN(CC)CC,,val
US20150299189A1,CC(C)(C)OC(=O)c1cc(C2CC2)cnc1Nc1cccc2c1ccn2CC1CCCCO1>>O=C(O)c1cc(C2CC2)cnc1Nc1cccc2c1ccn2CC1CCCCO1,,ClCCl,O=C(O)C(F)(F)F,,,val
US04788195,C=CCBr.Oc1ccc(Nc2nccc(-c3cccnc3)n2)cc1>>C=CCOc1ccc(Nc2nccc(-c3cccnc3)n2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100056563A1,CCOC(=O)CC(=O)OCC.O=c1oc(=O)n(Cc2ccc(C(F)(F)F)nc2)c2ncccc12>>CCOC(=O)c1c(O)c2cccnc2n(Cc2ccc(C(F)(F)F)nc2)c1=O,,CN(C)C=O,ClCCl,Cl,[H-].[Na+],val
US20140288123A1,COC(=O)c1ccc(C(C)OC2CCOCC2)cc1>>CC(OC1CCOCC1)c1ccc(C(=O)O)cc1,,CO,O,Cl,[Li+].[OH-],val
US20150025070A1,N#Cc1ccc(CNCc2nc3c(c(=O)[nH]2)COCC3)s1.O=C(O)CN1CCC(C(=O)c2ccc(F)cc2)CC1>>N#Cc1ccc(CN(Cc2nc3c(c(=O)[nH]2)COCC3)C(=O)CN2CCC(C(=O)c3ccc(F)cc3)CC2)s1,,O=CO,,CC#N,O,val
US03969368,O=C(O)CC1(c2ccccc2)Oc2ccc(Cl)cc2O1.c1ccccc1>>CCOC(=O)CCC1(c2ccccc2)Oc2ccc(Cl)cc2O1,,c1ccccc1,,O=S(Cl)Cl,,val
US20060074102A1,CN(C)S(=O)(=O)Cl.NC(=O)c1cc2c(-c3cccc(N)c3)cncc2s1>>CN(C)S(=O)(=O)Nc1cccc(-c2cncc3sc(C(N)=O)cc23)c1,,c1ccncc1,,,,val
US04908386,CCCCC(=O)NCc1ccc(C#CCCOCCCCCCNCc2ccccc2)cc1.c1ccc(C2OCc3nc(C4CO4)ccc3O2)cc1>>CCCCC(=O)NCc1ccc(C#CCCOCCCCCCN(Cc2ccccc2)CC(O)c2ccc3c(n2)COC(c2ccccc2)O3)cc1,,CO,,,,val
US20050239767A1,Cc1cccc(-c2nc3c(C)cccc3n2CC(O)C(C)(C)C)c1[N+](=O)[O-]>>Cc1cccc2c1OC(C(C)(C)C)Cn1c-2nc2c(C)cccc21,,CN(C)C=O,,[H-].[Na+],,val
US20110275611A1,CN.CS(=O)(=O)c1nc(Cl)cc(N2C[C@@H](C(=O)NCc3ccccc3)CC[C@H]2C(F)(F)F)n1>>CNc1nc(Cl)cc(N2C[C@@H](C(=O)NCc3ccccc3)CC[C@H]2C(F)(F)F)n1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US05223619,Cn1cnc(C(N)=O)c1N.O=C(N=C=S)c1ccccc1>>Cn1cnc(C(N)=O)c1NC(=S)NC(=O)c1ccccc1,,CC(C)=O,,,,val
US05272143,CC(C)=O.NCC1CNC(=O)c2cccc3[nH]cc1c23>>CC(C)NCC1CNC(=O)c2cccc3[nH]cc1c23,,C1CCOC1,,O,,val
US20120136002A1,CC(C)(C)OC(=O)NC1CCC(NC(=O)c2cc(Oc3ccc(C#N)cc3)cc(Oc3ccc(C#N)cc3)c2)CC1>>CC(C)(C)OC(=O)NC1CCC(NC(=O)c2cc(Oc3ccc(CN)cc3)cc(Oc3ccc(CN)cc3)c2)CC1,[Ni],CO,N,,,val
US20130281366A1,CCOC(=O)CN(CC(=O)OCC)c1ncc(C(C)=NO)o1.FC(F)(F)c1ccc(CBr)cc1>>CCOC(=O)CN(CC(=O)OCC)c1ncc(C(C)=NOCc2ccc(C(F)(F)F)cc2)o1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110112293A1,CNCCCN=[N+]=[N-].O=C(Cl)c1ccc(S(=O)(=O)Cl)cc1>>CN(CCCN=[N+]=[N-])C(=O)c1ccc(S(=O)(=O)Cl)cc1,,ClCCl,,,,val
US20140296252A1,CCc1nc(F)ccc1Oc1ccnc(-c2cnn(C)c2)c1.NN>>CCc1nc(NN)ccc1Oc1ccnc(-c2cnn(C)c2)c1,,CC(C)O,,O,O=C([O-])O.[Na+],val
US20100267827A1,CC(C)=CCC/C(C)=C/CN.COc1ccc(C(=O)O)cc1OCC=C(C)CCC=C(C)C>>COc1ccc(C(=O)NCC=C(C)CCC=C(C)C)cc1OCC=C(C)CCC=C(C)C,,C1CCOC1,,,,val
US20130295051A1,CS/C(=N\C#N)Nc1ccncc1.NCc1ccc(S(=O)(=O)Cc2ccccc2)cc1>>N#C/N=C(\NCc1ccc(S(=O)(=O)Cc2ccccc2)cc1)Nc1ccncc1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20160016968A1,C1CC2(CN1)COC2.CC(C)(C)c1nc(-c2cc(Cl)c(C3CC3)cn2)no1>>CC(C)(C)c1nc(-c2cc(N3CCC4(COC4)C3)c(C3CC3)cn2)no1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20140205537A1,CCOC(=O)Cc1cc(SC)ccc1[N+](=O)[O-]>>CSc1ccc2c(c1)CC(=O)N2,[Fe],CC(=O)O,,,,val
US05041455,CCOCCOCCOc1nsnc1-c1cccnc1.CI>>CCOCCOCCOc1nsnc1-c1ccc[n+](C)c1.[I-],,CC(C)=O,,,,val
US06083943,CC(C)(C)[Si](C)(C)Cl.COC(=O)[C@H]1[C@H](COCc2ccccc2)[C@@H](CO)N(C(=O)OCc2ccccc2)[C@H]1c1ccccc1>>COC(=O)[C@H]1[C@H](COCc2ccccc2)[C@@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)OCc2ccccc2)[C@H]1c1ccccc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20150336949A1,Cc1ccc(S(=O)(=O)n2cc(-c3c(C)nn(Cc4cccc(F)c4)c3C)c3cc(-c4cccc(N5CCNCC5)c4)cnc32)cc1.OCCBr>>Cc1ccc(S(=O)(=O)n2cc(-c3c(C)nn(Cc4cccc(F)c4)c3C)c3cc(-c4cccc(N5CCN(CCO)CC5)c4)cnc32)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140128372A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(CN)(NC(CO)c1ccccc1)C(F)(F)F>>CC(C)(C)OC(=O)NCC(C)(NC(CO)c1ccccc1)C(F)(F)F,,C1CCOC1,,CCN(CC)CC,,val
US20130190309A1,Nc1cccc2c1C(=O)N(c1cccc(C(F)(F)F)c1)CC2.O=C(O)c1cnccn1>>O=C(Nc1cccc2c1C(=O)N(c1cccc(C(F)(F)F)c1)CC2)c1cnccn1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120184542A1,COc1ncc2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1.NCc1ccncc1>>COc1ncc2cc(C(=O)Nc3cc(C(=O)NCc4ccncc4)ccc3Cl)c(=O)[nH]c2n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05623081,CC(C)C[C@H](N)C(=O)O.O=C(Cl)OC(Cl)(Cl)Cl>>CC(C)C[C@@H]1NC(=O)OC1=O,,C1CCOC1,,,,val
US20120088664A1,CC(=O)C(C)(C)C.O=Cc1ccc(Cl)cc1Cl>>CC(C)(C)C(=O)C=Cc1ccc(Cl)cc1Cl,,CCO,O,[Na+].[OH-],,val
US20070049607A1,CC(C)(C)OC(=O)n1ccc2ccc(Cn3nnc4c(-c5ccco5)nc(N)nc43)cc21>>Nc1nc(-c2ccco2)c2nnn(Cc3ccc4cc[nH]c4c3)c2n1,,CO,,C[O-].[Na+],,val
US20140243322A1,CC(C)(C)OC(=O)NCCOCCOCCOCCOCCN.COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)O)c1nnc(C)n1-2>>COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)c1nnc(C)n1-2,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20120035237A1,CCCCOc1ccccc1CBr.CCOC(=O)c1cc[nH]n1>>CCCCOc1ccccc1Cn1ccc(C(=O)OCC)n1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20140080808A1,CC1(C)OB(c2cnccc2C#N)OC1(C)C.CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(C3(c4ccc(Br)cc4)CC3)n2CCS1>>CC1(CO)Cc2nnc(C3(c4ccc(-c5cnccc5C#N)cc4)CC3)n2CCS1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US05840732,O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C1CSC(=O)N1CCCCOc1cccn2ccnc12>>O=C1CSC(=O)N1CCCCOc1cccn2c(C(=O)C(F)(F)F)cnc12,,ClCCl,,CCN(CC)CC,[Na+].[OH-],val
US20140206663A1,CCOC(=O)C(C)N1C(=O)COc2cc(F)c([N+](=O)[O-])cc21.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)C(C)N1C(=S)COc2cc(F)c([N+](=O)[O-])cc21,,Cc1ccccc1,,,,val
US20040147612A1,BrBr.COc1ccc2cc(CO)ccc2c1>>COc1ccc2cc(CBr)ccc2c1,,C1CCOC1,ClCCl,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20080319080A1,N#Cc1cc(F)c(F)c(F)c1.OCc1ccccc1>>N#Cc1cc(F)c(OCc2ccccc2)c(F)c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20050176743A1,C=O.CS(=N)(=O)c1ccc([N+](=O)[O-])cc1>>CN=S(C)(=O)c1ccc([N+](=O)[O-])cc1,,O=CO,,,,val
US20070276138A1,CCO.O=C(O)[C@@H](O)Cc1ccc(O)cc1>>CCOC(=O)[C@@H](O)Cc1ccc(O)cc1,,O=S(=O)(O)O,,,,val
US20040167122A1,COc1cc([N+](=O)[O-])ccc1Cl.c1ccc(CN2CCNCC2)cc1>>COc1cc(N2CCN(Cc3ccccc3)CC2)ccc1[N+](=O)[O-],,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20160024016A1,CCOCC1(COCC)CCC(=O)CC1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOCC1(COCC)CC=C(OS(=O)(=O)C(F)(F)F)CC1,,C1CCOC1,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US06255494B1,BrCCCBr.CC(C)(C)OC(=O)N1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(O)cccc32)CC1>>CC(C)(C)OC(=O)N1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(OCCCBr)cccc32)CC1,,CN(C)C=O,,,,val
US05641784,CCCn1c(=O)c2[nH]c(C3CCC(C(=O)OC)C3)nc2n(CCC)c1=O>>CCCn1c(=O)c2[nH]c(C3CCC(C(=O)O)C3)nc2n(CCC)c1=O,,CCO,O,[K+].[OH-],,val
US20070213331A1,CC(=O)N1[C@@H](Cc2cc(F)cc(F)c2)[C@@H]([C@H]2C[C@@H](OCc3cccc(OC(F)(F)F)c3)CN2C(=O)OC(C)(C)C)OC1(C)C.Cl>>CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@@H](OCc2cccc(OC(F)(F)F)c2)CN1.Cl,,C1COCCO1,,,,val
US20040082625A1,C#CCBr.COc1ccc(-c2cc(C=O)ccc2O)cc1>>C#CCOc1ccc(C=O)cc1-c1ccc(OC)cc1,,CN(C)C=O,,[I-].[K+],,val
US05310951,C=CCc1c(OCCCOc2cccc(OCC(=O)OCC)c2CCC)ccc(C(=O)N2CCCC2)c1OC>>C=CCc1c(OCCCOc2cccc(OCC(=O)O)c2CCC)ccc(C(=O)N2CCCC2)c1OC,,CCCCCC,CCOC(C)=O,CO,[Li+].[OH-],val
US20140088079A1,CCOc1ccc(Cc2cc([C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc4ccccc4)[C@H](OCc4ccccc4)[C@H]3OCc3ccccc3)c3c(c2Cl)OCC3)cc1>>CCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3c(c2Cl)OCC3)cc1,[Pd],C1CCOC1,CO,,,val
US20090149456A1,Cc1ccc(C#C[Si](C)(C)C)cc1NC(=O)C(F)(F)F>>C#Cc1ccc(C)c(NC(=O)C(F)(F)F)c1,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160102107A1,CC(=O)OC(C)=O.COc1cc(Br)cnc1NN>>COc1cc(Br)cnc1NNC(C)=O,,C1COCCO1,,,,val
US20100210694A1,ClCBr.O=C(O)c1ccc(OCCCO[N+](=O)[O-])cc1>>O=C(OCCl)c1ccc(OCCCO[N+](=O)[O-])cc1,,C1CCOC1,CN(C)C=O,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20080045521A1,COC(=O)[C@H](Cc1ccc(OCCc2cccc(NCCN(C)C)n2)cc1)NC(=O)c1c(Cl)cccc1Cl>>CN(C)CCNc1cccc(CCOc2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)O)cc2)n1,,CC(=O)N(C)C,O,[Li+].[OH-],,val
US20140235620A1,CC(N=[N+]=[N-])c1nccc(Oc2ccc(F)cc2)n1>>CC(N)c1nccc(Oc2ccc(F)cc2)n1,[Pd],CCO,,,,val
US04551460,O=C1c2ccccc2C(=O)N1CCCCCCc1cnc2ccccc2c1>>NCCCCCCc1cnc2ccccc2c1,,CCO,,NN,O,val
US04946971,Cc1cc(C)c2c(c1C)OC(C)(C)CC2.O=S(=O)(O)Cl>>Cc1c(C)c(S(=O)(=O)Cl)c(C)c2c1OC(C)(C)CC2,,ClC(Cl)Cl,,,,val
US20080242654A1,COc1ccc(Cl)cc1C(=O)/N=c1\sc(C(C)(C)C)cn1CC1CNC1.CS(=O)(=O)Cl>>COc1ccc(Cl)cc1C(=O)/N=c1\sc(C(C)(C)C)cn1CC1CN(S(C)(=O)=O)C1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20080269211A1,CC(C)=O.Cc1ccc(O)cn1>>CC(C)(O)Cc1ccc(O)cn1,,C1CCOC1,,[Li]CCCC,,val
US05455258,CCOC(=O)N1CCC(=O)CC1.[C-]#N.[NH4+]>>CCOC(=O)N1CCC(N)(C#N)CC1,,O,,[Na+].[OH-],[Cl-].[NH4+],val
US05104867,CCI.COc1ccc(CS[C@@H]2CN[C@H](C(N)=O)C2)cc1>>CCN1C[C@@H](SCc2ccc(OC)cc2)C[C@H]1C(N)=O,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US05932582,Cc1cc(OCCN(C)C(=O)OC(C)(C)C)ccc1NC(=O)c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)cc1>>CNCCOc1ccc(NC(=O)c2ccc(N3CCNCC3)cc2)c(C)c1,,CCOC(C)=O,,Cl,,val
US20100081692A1,CC1(C)OC[C@@](C)(CO)O1.COC(=O)C(C)c1ccc(F)cc1O>>COC(=O)C(C)c1ccc(F)cc1OC[C@]1(C)COC(C)(C)O1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050222410A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(C2=CCN(C(=O)OC(C)(C)C)CC2)s1>>Nc1ccccc1NC(=O)c1ccc(C2=CCNCC2)s1,,C1COCCO1,,Cl,,val
US20120214786A1,CNc1cc(F)c(C(=O)Nc2ccc(Br)cc2)cc1NC(=S)Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl>>Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(Br)cc3)c(F)cc21,,CN(C)C=O,,CC(C)N=C=NC(C)C,,val
US04788130,Cc1cc(C)c2c(c1O)C(N)C(C)(C)C2.Clc1cccc(N2CCN(CC3CO3)CC2)c1>>Cc1cc(C)c2c(c1O)C(NCC(O)CN1CCN(c3cccc(Cl)c3)CC1)C(C)(C)C2,,CCO,,Cl,O=C([O-])O.[Na+],val
US20050187272A1,CCOC(C)=O.O=C(O)c1ccc[nH]1.O=[N+]([O-])c1ccc(F)cc1>>CCOC(=O)c1cccn1-c1ccc([N+](=O)[O-])cc1,,CN(C)C=O,,[H-].[Na+],,val
US20120148502A1,BrCc1ccccc1.CO[C@H]1O[C@@H]2COC(c3ccccc3)O[C@H]2[C@H](O)[C@@H]1O>>COC1OC2COC(c3ccccc3)OC2C(OCc2ccccc2)C1O,,CO,,CCOC(C)=O,O=C([O-])O.[Na+],val
US05374454,[K].c1ccc2cc3ccccc3cc2c1>>[K].c1ccc2cc3ccccc3cc2c1,,COCCOC,,,,val
US20020040146A1,CC(C)(C)OC(=O)N1C[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1COCc1cc(F)c(F)cc1F>>Fc1cc(F)c(COC[C@@H]2C[C@@H](SC(c3ccccc3)(c3ccccc3)c3ccccc3)CN2)cc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US04426380,CI.O=C1Cc2cc(Cl)c(N3CCCCC3)cc2O1>>CC1C(=O)Oc2cc(N3CCCCC3)c(Cl)cc21,,COCCOC,,[H-].[Na+],,val
US05652271,CN(C)CCCSCC(O)C1(c2ccc(Cl)c(Cl)c2)CCC1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CN(C)CCCSCC(O)C1(c2ccc(Cl)c(Cl)c2)CCC1.O=C(O)CC(O)(CC(=O)O)C(=O)O,,CCO,CCOCC,,,val
US20060270635A1,Nc1ccc(C(=O)O)c(O)c1.O=N[O-].S=c1cc(-c2ccccc2)ss1>>O=C(O)c1cc(N=Nc2ccc(-c3cc(=S)ss3)cc2)ccc1O,,Cl,O,CN(C)C=O,,val
US20130225524A1,CC(C)=CB(O)O.Nc1cc(Br)cc(C(=O)O)c1>>CC(C)=Cc1cc(N)cc(C(=O)O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20090221555A1,COc1cc2c(cc1N)NC(=O)CN(C(C)=O)C2.CS(=O)(=O)N[C@@H]1CCCC[C@H]1Nc1nc(Cl)ncc1Cl>>COc1cc2c(cc1Nc1ncc(Cl)c(N[C@@H]3CCCC[C@H]3NS(C)(=O)=O)n1)NC(=O)CN(C(C)=O)C2,,CO,ClCCl,,,val
US20060160771A1,COP(=O)(OC)OCC(CCc1ccc(Sc2cccc(OCc3ccccc3)c2)cc1Cl)(CO[Si](C)(C)C(C)(C)C)NC(=O)OC(C)(C)C>>COP(=O)(OC)OCC(CO)(CCc1ccc(Sc2cccc(OCc3ccccc3)c2)cc1Cl)NC(=O)OC(C)(C)C,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20050065213A1,COc1ccc(C2CC(=O)c3cc(OC)c(OC)c(OC)c32)cc1[N+](=O)[O-]>>COc1ccc(C2CC(=O)c3cc(OC)c(OC)c(OC)c32)cc1N,[Pd],CO,,,,val
US20040152894A1,COC(=O)Cc1ccccc1COc1cc(C(F)(F)F)nc(OC(C)C)n1.COC=O>>COC(=O)C(=CO)c1ccccc1COc1cc(C(F)(F)F)nc(OC(C)C)n1,Cl[Ti](Cl)(Cl)Cl,CCN(CC)CC,,Cl,ClCCl,val
US20050250797A1,C#CCOCC(=O)N(C)C.Nc1c(Cl)cc(I)c2c1OCO2>>CN(C)C(=O)COCC#Cc1cc(Cl)c(N)c2c1OCO2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,,CC(C)NC(C)C,,val
US20150376225A1,CC1([C@H]2CC[C@H]3[C@@H]4CCC5CC6(CC[C@]5(C)[C@H]4[C@@H](O)C[C@@]32C)OCCO6)OCCO1>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4CC5(CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C)OCCO5,,CC(C)=O,O,O=S(=O)(O)O,,val
US20070185176A1,C=C(CC(=O)O)C(=O)O.Nc1ccc(Oc2ccccc2)cc1>>O=C(O)C1CC(=O)N(c2ccc(Oc3ccccc3)cc2)C1,,CCOC(C)=O,,,,val
US20140121198A1,N#CC[C@@H]1CC[C@@H](Nc2c([N+](=O)[O-])cnc3ccsc23)CC1>>N#CC[C@@H]1CC[C@@H](Nc2c(N)cnc3ccsc23)CC1,[Pd],CO,,,,val
US20070197604A1,CC(C)(C)OC(=O)N1CC[C@@H](O)C1.COCCN(CCOC)S(F)(F)F>>CC(C)(C)OC(=O)N1CC[C@H](F)C1,,ClCCl,,O=C([O-])O.[Na+],,val
US20120115844A1,CC(C)N.Cn1nnc(-c2ccc(F)cc2)c1/C=C/c1ccc(C(=O)O)cn1>>CC(C)NC(=O)c1ccc(/C=C/c2c(-c3ccc(F)cc3)nnn2C)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20130035331A1,CN(C)C=O.Cc1ccc(Cl)nc1.Cc1ccc(Cl)nc1Br>>Cc1ccc(Cl)nc1Br.Cc1ccc(Cl)nc1C=O,,C1CCOC1,,[Li]CCCC,,val
US20150329542A1,CC(C)(C)OC(=O)N1CCC(C#N)CC1.COc1ccc(N(C)S(C)(=O)=O)c(CNc2nc(-c3cc(F)c(OC)cc3CC(F)(F)F)nc3c2c(C(=O)NN)nn3COCC[Si](C)(C)C)c1>>COc1ccc(N(C)S(C)(=O)=O)c(CNc2nc(-c3cc(F)c(OC)cc3CC(F)(F)F)nc3[nH]nc(-c4nnc(C5CCNCC5)[nH]4)c23)c1,,CCCCO,,,,val
US20150031670A1,CCOC(=O)Cl.O=C1CCCCN1c1ccccc1>>CCOC(=O)C1CCCN(c2ccccc2)C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US03950338,CCOC(=O)c1cn(CC)c2ncncc2c1=O>>CCn1cc(C(=O)O)c(=O)c2cncnc21,,CC(=O)O,,O=C([O-])[O-].[Na+].[Na+],,val
US05767116,COc1cccc2c1OC(CO)CO2.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1cccc2c1OC(COS(=O)(=O)c1ccc(C)cc1)CO2,,c1ccncc1,,Cl,,val
US20070167476A1,CC(C)(C)OC(=O)NCC(CNc1c([N+](=O)[O-])cnc2ccccc12)O[Si](C)(C)C(C)(C)C>>CC(C)(C)OC(=O)NCC(CNc1c(N)cnc2ccccc12)O[Si](C)(C)C(C)(C)C,,ClCCl,,,,val
US20060084676A1,CC(C(=O)O)c1ccccc1.COC(=O)c1ccccc1N.O=S(Cl)Cl>>COC(=O)c1ccc(Cl)cc1NC(=O)C(C)c1ccccc1,,CCOC(C)=O,,CCCCCC,,val
US20100120739A1,Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.O=C(O)Cc1ccc2ncc(Br)cc2c1>>Cn1cc(-c2cnc3ccc(CC(=O)O)cc3c2)cn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20100029650A1,CS(=O)(=O)c1ccc(-c2ccc(OCC3CCNCC3)cc2)cc1.N#CBr>>CS(=O)(=O)c1ccc(-c2ccc(OCC3CCN(C#N)CC3)cc2)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US06203154B1,C=C(C)C(=O)Cl.CCCl.CCN(CC)CC.Nc1ccc(-c2ccc(N)cc2)cc1>>C=C(C)C(=O)N(CC)c1ccc(-c2ccc(N(CC)CC)cc2)cc1,,ClCCl,O,,,val
US20130053565A1,CC(C)(C)OC(=O)N1CC(=O)C1.C[Si](C)(C)C#Cc1ccoc1>>CC(C)(C)OC(=O)N1CC(=O)C([Si](C)(C)C)=C(c2ccoc2)C1,,Cc1ccccc1,,,,val
US20090029903A1,CC1(C)OC(=O)c2ccc(C=O)cc2O1.CCCCCCc1ccc(C#Cc2ccc(N)cc2)cc1>>CCCCCCc1ccc(C#Cc2ccc(NCc3ccc4c(c3)OC(C)(C)OC4=O)cc2)cc1,,O,,[BH4-].[Na+],,val
US20140148430A1,CC1(C)OB(c2ccc3cn[nH]c3c2)OC1(C)C.COC(=O)c1c(Br)cc(Nc2ccc(N3CCOCC3)cn2)c2nccn12>>COC(=O)c1c(-c2ccc3cn[nH]c3c2)cc(Nc2ccc(N3CCOCC3)cn2)c2nccn12,,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20090176963A1,O=S(=O)(O)C(F)(F)F.c1ccncc1>>O=S(=O)([O-])C(F)(F)F.c1cc[nH+]cc1,,ClCCl,,,,val
US20160168090A1,NCC1CC(C(F)(F)F)CC(F)(F)C1.O=C(O)c1cn(C2COC2)c2cccc(Cl)c12>>O=C(NCC1CC(C(F)(F)F)CC(F)(F)C1)c1cn(C2COC2)c2cccc(Cl)c12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030092677A1,CC(C)(C)OC(=O)Nc1ccc(C(=O)c2ccccc2)cc1[N+](=O)[O-]>>CC(C)(C)OC(=O)Nc1ccc(C(=O)c2ccccc2)cc1N,[Ni],,,,,val
US20160090374A1,CC(=O)Cl.COc1ccc2nc(Cl)nc(N3CCC[C@@H](N)C3)c2c1>>COc1ccc2nc(Cl)nc(N3CCC[C@@H](NC(C)=O)C3)c2c1,,ClCCl,,CCN(CC)CC,,val
US20150087646A1,CC(C)(C)OC(=O)NNc1ccc(C#N)cc1.O=C=NC(=O)c1c(F)cccc1Cl>>CC(C)(C)OC(=O)NN(C(=O)NC(=O)c1c(F)cccc1Cl)c1ccc(C#N)cc1,,ClCCl,,,,val
US20040034047A1,CC(=O)Nc1ccc(S)cc1.COc1cc(Cc2cnc(N)nc2N)c2cc(CCl)oc2c1OC>>COc1cc(Cc2cnc(N)nc2N)c2cc(CSc3ccc(NC(C)=O)cc3)oc2c1OC,,O=CO,,[H-].[Na+],,val
US20160024009A1,CCI.COC(=O)[C@H](CO)NS(=O)(=O)c1ccc(F)cc1>>CCN([C@@H](CO)C(=O)OC)S(=O)(=O)c1ccc(F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040220236A1,Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc(-c2nc3ccccc3s2)cc1>>Cc1ccc(S(=O)(=O)Nc2ccc(-c3nc4ccccc4s3)cc2)cc1,,c1ccncc1,,O,,val
US20080153810A1,CC(C)(C)OC(=O)N(CCN1CCCCC1)c1nn(C(=O)OC(C)(C)C)c2cc(N)ccc12.O=C(O)c1ccc(-c2ccc(Cl)cc2)s1>>CC(C)(C)OC(=O)N(CCN1CCCCC1)C1=NN(C(=O)OC(C)(C)C)C2C=C(NC(=O)c3ccc(-c4ccc(Cl)cc4)s3)C=CC12,,CCOC(C)=O,ClCCl,O=C(Cl)C(=O)Cl,,val
US20080090834A1,Cc1ccc(-n2cc(-c3nccs3)nc2-c2ccc(Nc3ncccc3[N+](=O)[O-])cc2)cn1>>Cc1ccc(-n2cc(-c3nccs3)nc2-c2ccc(Nc3ncccc3N)cc2)cn1,[Pd],,,[H][H],,val
US20050009907A1,COC(CBr)OC.Cc1ccc(Br)c(O)c1>>COC(COc1cc(C)ccc1Br)OC,,CCO,,C,C[O-].[Na+],val
US20090239848A1,CCOC(=O)CC(=O)N1CCN(C(=O)OC(C)(C)C)CC1.Cl>>CCOC(=O)CC(=O)N1CCNCC1.Cl,,C1COCCO1,,,,val
US20150111887A1,COC(=O)C(C)(c1ccc(F)cc1)c1cnc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1>>CC(C)(C)OC(=O)N1CCN(c2ncc(C(C)(CO)c3ccc(F)cc3)cn2)CC1,,C1CCOC1,,[BH4-].[Li+],,val
US20150291554A1,C[C@@H]1CC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)CN1.N#CBr>>C[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)CN1C#N,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20040127424A1,CC(C)C[C@@H]1CC(=O)OC1=O.c1ccc(-c2cc[nH]c2)cc1>>CC(C)C[C@H](CC(=O)n1ccc(-c2ccccc2)c1)C(=O)O,,C1CCOC1,,[H-].[Na+],,val
US20090099195A1,CC(C)(N)Cc1ccc(Cl)cc1.CC(C)N1Cc2c(Cl)nc(Cl)nc2C1=O>>CC(C)N1Cc2c(NC(C)(C)Cc3ccc(Cl)cc3)nc(Cl)nc2C1=O,CN(C)C=O,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20050130997A1,CI.COC(=O)c1nc(-c2cscc2NC(=O)OC(C)(C)C)nc(O)c1OC(=O)C(C)(C)C>>COC(=O)c1nc(-c2cscc2NC(=O)OC(C)(C)C)nc(OC)c1OC(=O)C(C)(C)C,,C1CCOC1,Cl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090076005A1,Cc1c(C(=O)[O-])c(C)n(-n2nnc3cccnc32)c1/C=C1\C(=O)Nc2ccc(F)cc21.NC1CCC(C(=O)O)CC1>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC1CCC(C(=O)O)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20060063812A1,CC(=O)C(Cl)Cl.NC(=O)c1cc2cc(OC(F)(F)F)ccc2[nH]1>>FC(F)(F)Oc1ccc2[nH]c(-c3nc(CCl)co3)cc2c1,,CN(C)C=O,Cc1ccccc1,,,val
US20070037802A1,CC(O)c1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1.CS(=O)(=O)OS(C)(=O)=O>>CC(OS(C)(=O)=O)c1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1,,ClCCl,,CCN(CC)CC,,val
US20080108689A1,Cc1cc(F)ccc1[C@@H]1[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC[C@H](CO)[C@H]1CO.NCc1ccccc1>>Cc1cc(F)ccc1[C@@H]1[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC[C@@H]2CN(Cc3ccccc3)C[C@H]21,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US20030092917A1,C1COCCN1.ClCC1CO1>>OC(CCl)CN1CCOCC1,,CCO,,,,val
US20140357637A1,CC1(C(=O)NC2CC2)C(=O)Nc2nc(-c3nn(CCC(F)(F)F)c4ncccc34)nc(N)c21.ICI>>CC1(C(=O)NC2CC2)C(=O)Nc2nc(-c3nn(CCC(F)(F)F)c4ncccc34)nc(I)c21,,C1COCCO1,,CC(C)CCON=O,,val
US20120065196A1,COC(=O)[C@@H]1CC[C@@H](C(=O)O)CC1.O=C(Cl)C(=O)Cl>>COC(=O)[C@@H]1CC[C@@H](C(=O)Cl)CC1,CN(C)C=O,ClCCl,,,,val
US04190666,Cl.FC(F)C(F)(F)Sc1nc(-c2ccccc2)c(-c2ccccc2)[nH]1>>Cl.FC(F)C(F)(F)Sc1nc(-c2ccccc2)c(-c2ccccc2)[nH]1,,C1CCOC1,CCOCC,,,val
US20090162283A1,CC(=O)c1ccc(-c2nc3cc(Br)ccc3[nH]2)cc1.COC(OC)N(C)C>>CN(C)/C=C/C(=O)c1ccc(-c2nc3cc(Br)ccc3[nH]2)cc1,,CN(C)C=O,,,,val
US20140296136A1,COC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)O[C@@H]1C[C@H]1CCCCCc1c(nc3ccccc3c1O)O2.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)O[C@@H]1C[C@H]1CCCCCc1c(nc3ccccc3c1OS(=O)(=O)C(F)(F)F)O2,,c1ccncc1,,O,,val
US20090197862A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1cc2cccc(Cl)c2cn1>>O=S(=O)(Oc1cc2cccc(Cl)c2cn1)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20100160309A1,CC(C)(C)O.O=C(O)C1CCOCC1>>CC(C)(C)OC(=O)C1CCOCC1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,ClCCCl,val
US20160039815A1,CC(C)CCC1=C(c2cccc(Cl)c2)NCc2c1c(=O)n(CCCOC=O)c(=O)n2C.CC(C)CCc1c(-c2cccc(Cl)c2)ncc2c1c(=O)n(CCCOC=O)c(=O)n2C>>CC(C)CCc1c(-c2ccc(Cl)cc2)ncc2c1c(=O)n(CCCOC=O)c(=O)n2C,O=[Mn]=O,ClCCl,O,,,val
US20040102481A1,CN1CC=C(c2c[nH]c3ccc(O)cc23)CC1.O=S(=O)(Cl)c1c(F)cccc1F>>CN1CC=C(c2c[nH]c3ccc(OS(=O)(=O)c4c(F)cccc4F)cc23)CC1,,C1CCOC1,,[Na+].[OH-],,val
US20100160280A1,CC(C)(O)C1CCNC1.Clc1nccnc1Oc1ccc(Nc2ccccn2)cc1>>CC(C)(O)C1CCN(c2nccnc2Oc2ccc(Nc3ccccn3)cc2)C1,,CS(C)=O,,,,val
US20070219251A1,CC(C)Oc1ccc(Oc2ncc(-c3cncc(C(C)N)c3)s2)cc1.CN=C=O>>CNC(=O)NC(C)c1cncc(-c2cnc(Oc3ccc(OC(C)C)cc3)s2)c1,,ClCCl,,,,val
US20100022613A1,CN(C)C=O.Fc1ccc(CSc2cccc(Br)c2)cc1>>O=Cc1cccc(SCc2ccc(F)cc2)c1,,C1CCOC1,,[Li]CCCC,,val
US20080019915A1,COc1ncc(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)ccc2C)cn1>>Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1-c1cnc(O)nc1,,CC#N,,C[Si](C)(C)I,,val
US20060211730A1,CC(C)S(=O)(=O)Cl.Cc1cc(COc2ccc(S(=O)(=O)N[C@@H]3CCNC[C@]3(C)C(=O)NOC(C)(C)C)cc2)c2ccccc2n1>>Cc1cc(COc2ccc(S(=O)(=O)N[C@@H]3CCN(S(=O)(=O)C(C)C)C[C@]3(C)C(=O)NOC(C)(C)C)cc2)c2ccccc2n1,,CCOC(C)=O,ClCCl,O=C([O-])O.[Na+],,val
US05760041,O=[N+]([O-])c1ccc2ncnc(Nc3cccc(Br)c3)c2c1>>Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1,[Fe],CC(=O)O,CCO,,,val
US20070249688A1,FC(F)(F)c1ccc(-c2ccc(OCc3ccccc3)cc2)nc1>>Oc1ccc(-c2ccc(C(F)(F)F)cn2)cc1,[Pd],C1CCOC1,CCO,[H][H],,val
US20110224188A1,CCOC(=O)CC(=O)[C@@H]1CCN(C(=O)C2(NC(=O)c3cnc4n3[C@](C)(Cc3ccc(OC(F)(F)F)cc3)C(=O)N4c3cc(Cl)cc(Cl)c3)CC2)C1.NN>>C[C@@]1(Cc2ccc(OC(F)(F)F)cc2)C(=O)N(c2cc(Cl)cc(Cl)c2)c2ncc(C(=O)NC3(C(=O)N4CC[C@@H](c5cc(O)n[nH]5)C4)CC3)n21,,CCO,,,,val
US04864052,CC(C)=CC1C(C(=O)OCc2cccc(Oc3ccccc3)c2)C1(C)C.O=[O+][O-]>>CC1(C)C(C=O)C1C(=O)OCc1cccc(Oc2ccccc2)c1,,CCOC(C)=O,,,,val
US20110087032A1,Cc1cc(C)c(N=CNc2c(C)cc(C)cc2C)c(C)c1>>Cc1cc(C)c(N=CNc2c(C)cc(C)cc2C)c(C)c1,,O,,Cl,c1ccncc1,val
US20150140573A1,OCc1ccc(O)cc1.[N-]=[N+]=NCCCCl>>[N-]=[N+]=NCCCOc1ccc(CO)cc1,,CN(C)C=O,,CCOCC,O=C([O-])[O-].[K+].[K+],val
US20120065195A1,CN1C(=O)C2(CC(C)(C)Cc3ccc(Br)nc32)N=C1N.OB(O)c1cccc(Cl)c1>>CN1C(=O)C2(CC(C)(C)Cc3ccc(-c4cccc(Cl)c4)nc32)N=C1N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20150045348A1,O=S(Cl)Cl.O=c1[nH]c(CO)nn2c(C3CCOCC3)ncc12>>O=c1[nH]c(CCl)nn2c(C3CCOCC3)ncc12,,ClCCl,,,,val
US20050256099A1,CCN(CC)CC.Cc1cc(CC(=O)C(=O)O)cc2cn[nH]c12>>CCOC(=O)[C@H](O)Cc1cc(C)c2[nH]ncc2c1,,C1CCOC1,,,,val
US06372770B1,C#CC(C)O.Clc1cc(Br)c2oc(-c3ccccc3Cl)nc2c1>>CC(O)C#Cc1cc(Cl)cc2nc(-c3ccccc3Cl)oc12,[Cu]I,Cc1ccccc1,,CCN(CC)CC,,val
US20020040020A1,Cc1cc(C(=O)O)ccc1Cl.O=C(Cl)C(=O)Cl>>Cc1cc(C(=O)Cl)ccc1Cl,,ClCCl,,CN(C)C=O,,val
US20150119380A1,Cc1cn2nc(-c3cc4ccc(C5CCN(C(=O)OC(C)(C)C)CC5)cc4oc3=O)cc2c(C)n1>>Cc1cn2nc(-c3cc4ccc(C5CCNCC5)cc4oc3=O)cc2c(C)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050234033A1,COC(=O)c1cnc(N2CCNCC2)s1.Cc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)c1cnc(N2CCN(S(=O)(=O)c3ccc(C)cc3)CC2)s1,,ClCCl,,CCN(CC)CC,O,val
US04702761,CCNCC.COP(=S)(Cl)OC>>CCN(CC)P(=S)(OC)OC,,ClCCl,,,,val
US05227389,CCCCN.CCOC(=O)C1(c2ccccc2)CCN(C)CC1>>CCCCNC(=O)C1(c2ccccc2)CCN(C)CC1,,CCOCC,,Cl,[Na+].[OH-],val
US20150329497A1,COc1cc2nc(C3CC3)nc(N3CCN(C(=O)OC(C)(C)C)CC3)c2cc1OC.O=C(O)C(F)(F)F>>COc1cc2nc(C3CC3)nc(N3CCNCC3)c2cc1OC.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20130317045A1,Cc1cc(C(N)=O)c(NC(=O)C(F)(F)c2ccc(F)cc2)s1>>Cc1cc2c(=O)[nH]c(C(F)(F)c3ccc(F)cc3)nc2s1,,ClCCCl,,C[Si](C)(C)Cl,,val
US05043152,CC(C)C1OCC(C(=O)Cl)CO1.Nc1cc(C(=O)NCCO)cc([N+](=O)[O-])c1>>CC(C)C1OCC(C(=O)Nc2cc(C(=O)NCCO)cc([N+](=O)[O-])c2)CO1,,CC(=O)N(C)C,,CCN(CC)CC,,val
US20040220411A1,CC(=O)O.Cc1nc(-c2cccc(CN(CC(C)C)C(=O)C(=O)Nc3ccc(-c4ccccc4S(=O)(=O)NC(C)(C)C)cc3)c2)no1>>CC(=O)O.CC(C)CN(Cc1cccc(C(=N)N)c1)C(=O)C(=O)Nc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1,[Ni],CC(=O)O,O,CO,,val
US20100240620A1,CCOC(C)=O.CCc1cnc(C)s1>>CCc1cnc(CC(C)=O)s1,,C1CCOC1,,[Li]CCCC,,val
US20150087646A1,CC(C)(C)OC(=O)NNc1ccc(C(F)(F)F)cc1.N#Cc1cnc(C(F)F)c(C(=O)N=C=O)c1>>N#Cc1cnc(C(F)F)c(-c2nn(-c3ccc(C(F)(F)F)cc3)c(=O)[nH]2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04864052,CC(C)=CC1C(C(=O)OCc2c(F)c(F)c(F)c(F)c2F)C1(C)C.O=[O+][O-]>>CC1(C)C(C=O)C1C(=O)OCc1c(F)c(F)c(F)c(F)c1F,,CCOC(C)=O,,,,val
US20070191376A1,C#Cc1cnc2c(Nc3ccc(S(C)(=O)=O)cc3)cccn12.Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1I>>Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1C#Cc1cnc2c(Nc3ccc(S(C)(=O)=O)cc3)cccn12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05283355,CCC(C)O.O=C1C(Cl)=C(Cl)C(=O)C(Cl)=C1Cl>>CCC(C)OC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O,,CCC(C)=O,,O=C([O-])O.[Na+],,val
US20040106667A1,CC(=O)Cl.Nc1n[nH]c2ccc(NS(=O)(=O)c3cc(F)cc(F)c3)cc12>>CC(=O)Nc1n[nH]c2ccc(NS(=O)(=O)c3cc(F)cc(F)c3)cc12,,c1ccncc1,,,,val
US05707994,CCOC(=O)CCCOc1ccc(C(=N)N)cc1>>N=C(N)c1ccc(OCCCC(=O)O)cc1,,CC(=O)O,Cl,I,,val
US04147693,Cc1ccc(C=O)o1.NN1CCNC1=O>>CC1=CCC(=NN2CCNC2=O)O1,,O,,Cl,[Na+].[OH-],val
US06630004B1,NC1CCCCNC1=O.O=[N+]([O-])c1ccc(F)cc1>>O=C1NCCCCC1Nc1ccc([N+](=O)[O-])cc1,,CN(C)C=O,,CCN(CC)CC,,val
US20070166228A1,O=C(NCCN=Cc1ccccc1)C(Cc1ccc([N+](=O)[O-])cc1)N=Cc1ccccc1>>O=[N+]([O-])c1ccc(CC(CNCCNCc2ccccc2)NCc2ccccc2)cc1,,C1CCOC1,,B,,val
US20050027007A1,N[C@H]1c2ccccc2C[C@H]1O.O=C(Cl)CCc1ccccc1>>O=C(CCc1ccccc1)N[C@H]1c2ccccc2C[C@H]1O,,ClCCl,,CCN(CC)CC,,val
US20110124637A1,O=C(Nc1cccc2[nH]c(-c3cccc(C(F)(F)F)c3)nc12)OCc1ccccc1>>Nc1cccc2[nH]c(-c3cccc(C(F)(F)F)c3)nc12,[Pd],CO,,,,val
US04478967,CCCCCCCCCCCCCCCCCCN.O=[N+]([O-])c1ccccc1CCl>>NCCCCCCCCCCCCCCCCCCCc1ccccc1[N+](=O)[O-],,CCO,,,,val
US20060160862A1,CC(C)(C)OC(=O)[C@H](Cc1ccccc1)n1cccc(NC(=O)OCc2ccccc2)c1=O>>CC(C)(C)OC(=O)[C@H](Cc1ccccc1)n1cccc(N)c1=O,[Pd],CCOC(C)=O,CO,,,val
US20050113356A1,C=CC(=O)O.C=CCC(C)(C)C>>CC(C)(C)CC=CC(=O)O,[Ru],ClCCl,,,,val
US20150111892A1,CC(C)COC(=O)Cl.CCCCCCNC(=O)n1cc(Br)c(=O)[nH]c1=O>>CCCCCCNC(=O)n1cc(Br)c(=O)n(C(=O)OCC(C)C)c1=O,,c1ccncc1,,,,val
US20160081334A1,CC#Cc1cc(C)c(C2=C(OC)CC(CCNC(=O)c3ccccn3)C2=O)c(CC)c1>>CC#Cc1cc(C)c(C2C(=O)CC(CCNC(=O)c3ccccn3)C2=O)c(CC)c1,,CC(C)=O,,Cl,,val
US20160122339A1,BrCCBr.Nc1cnc2ccc(Br)cc2c1O>>Brc1ccc2ncc3c(c2c1)OCCN3,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110306591A1,Cc1ccc(S(=O)(=O)NC2CC(Oc3ncccc3C3=CCN(C(=O)OC(C)(C)C)CC3)C2)cc1>>Cc1ccc(S(=O)(=O)NC2CC(Oc3ncccc3C3CCN(C(=O)OC(C)(C)C)CC3)C2)cc1,[Pd],CO,,,,val
US20040110811A1,CC(C)C(C)I.O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1C(=O)c1cccc2ccccc12>>CC(C)CN1C(=O)N(C(=O)c2cccc3ccccc23)C(=O)C1(c1ccccc1)c1ccccc1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20080167307A1,CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCOc2ccc(C(=O)Nc3ccccc3)cc2)cs1>>CC(C)(Sc1nc(CCOc2ccc(C(=O)Nc3ccccc3)cc2)cs1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020031816A1,O=C(Nc1ccccc1)c1cccc([N+](=O)[O-])c1>>Nc1cccc(C(=O)Nc2ccccc2)c1,[Pd],CCO,,,,val
US04414390,CC(=O)OC(C)=O.O=C1CCc2cccc(O)c2N1.O=[N+]([O-])O>>CC(=O)Oc1cc([N+](=O)[O-])cc2c1NC(=O)CC2,O=S(=O)(O)O,CC(=O)OC(C)=O,,CC(=O)O,,val
US04281000,CCOC(=O)c1c[nH]nc1N.CN(C)C=CC(=O)c1cccnc1>>CCOC(=O)c1cnn2c(-c3cccnc3)ccnc12,,CC(=O)O,,,,val
US06441177B1,C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(OC)c1.O=C([O-])/C=C/C(=O)[O-]>>C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(O)c1.O=C(O)/C=C/C(=O)O,,ClCCl,,,,val
US20130310558A1,C#CCC(C(=O)OCC)C(=O)OCC.Clc1ccccc1/C=C/CBr>>C#CCC(CC=Cc1ccccc1Cl)(C(=O)OCC)C(=O)OCC,,C1CCOC1,,[H-].[Na+],,val
US20060258714A1,C=CCc1ccc(Cl)c(-c2ccccc2C)c1O>>CC=Cc1ccc(Cl)c(-c2ccccc2C)c1O,Cc1ccccc1[P](c1ccccc1C)(c1ccccc1C)[Pd](Cl)(Cl)[P](c1ccccc1C)(c1ccccc1C)c1ccccc1C,ClCCl,,,,val
US08022062B2,CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(SCCCC(=O)O)c2CC1.CN>>CNC(=O)CCCSc1c(Cl)ccc2c1CCN(C(=O)OC(C)(C)C)CC2,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20140179699A1,CS(=O)(=O)Cl.OCCc1cc(Cl)ccc1Br>>CS(=O)(=O)OCCc1cc(Cl)ccc1Br,,ClCCl,,CCN(CC)CC,,val
US20080255117A1,C#Cc1ccc(C(=O)NC)cc1.COc1ccc(Br)cc1S(=O)(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12>>CNC(=O)c1ccc(C#Cc2ccc(OC)c(S(=O)(=O)N[C@@H](CO)Cc3c[nH]c4ccccc34)c2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,CCO,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20130252953A1,Cc1cc(C)c(C#N)c(Cl)n1.NC(N)=S>>Cc1cc(C)c(C#N)c(S)n1,,CCCCO,,,,val
US05208228,CC(C)=[N+]=[N-].CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(O)C3)C(C)CCC1=O)C(C)CC2OC>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OC(C)C)C3)C(C)CCC1=O)C(C)CC2OC,,CCOCC,,FB(F)F,,val
US20110065934A1,C[Si](C)(C)N[Si](C)(C)C.O[C@@H](c1ccccc1)[C@@H](O)c1ccccc1>>C[Si](C)(C)O[C@@H](c1ccccc1)[C@@H](O[Si](C)(C)C)c1ccccc1,,ClCCl,,II,,val
US20090082358A1,FC(F)(F)c1ccc(C2=NCCc3cncnc32)cc1>>FC(F)(F)c1ccc(C2NCCc3cncnc32)cc1,,CO,,[BH4-].[Na+],,val
US20150133424A1,CC(C)(C(N)=O)c1cccc([N+](=O)[O-])c1>>CC(C)(C(N)=O)c1cccc(N)c1,[Pd],CO,,CC[SiH](CC)CC,,val
US20070161645A1,COc1cccc(CBr)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1.[Br-],,Cc1ccccc1,,,,val
US20110130400A1,O=C(O)c1cc2cc(Br)ccc2[nH]1.OB(O)c1ccncc1>>O=C(O)c1cc2cc(-c3ccncc3)ccc2[nH]1,Cl[Pd]Cl,O,,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US04879292,COc1ccc(Oc2cc(F)cc(F)c2)cc1>>Oc1ccc(Oc2cc(F)cc(F)c2)cc1,,CC(=O)O,,Br,,val
US20060074111A1,CCOC(=O)COc1ccc(S(=O)(=O)N(CCC2CC2)c2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1C>>Cc1cc(S(=O)(=O)N(CCC2CC2)c2cccc(-c3ccc(C(F)(F)F)cc3)c2)ccc1OCC(=O)O,,C1CCOC1,CO,[Na+].[OH-],,val
US20120178778A1,N#CCc1csc(-c2ccnc3c2cnn3C(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>N#CCc1csc(-c2ccnc3[nH]ncc23)n1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20140148457A1,COc1ccc(C(=O)Cl)cc1OC.NC(=O)c1nc(-c2ccccc2)sc1N>>COc1ccc(C(=O)Nc2sc(-c3ccccc3)nc2C(N)=O)cc1OC,,CN1CCCC1=O,,C1CCC2=NCCCN2CC1,,val
US04346088,Br.CN1C(=Nc2ccccc2)SCC1(O)c1ccc(Cl)c(S(=O)(=O)Cl)c1>>Br.Cn1c(-c2ccc(Cl)c(S(=O)(=O)Cl)c2)csc1=Nc1ccccc1,,O,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20150105391A1,Cc1cc(N2CCC(=O)CC2)cc(C)c1-c1csc(NC(=O)c2ccncc2)n1>>Cc1cc(N2CCC(O)CC2)cc(C)c1-c1csc(NC(=O)c2ccncc2)n1,,CO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20150196566A1,CCOC(=S)[S-].N#Cc1cc(F)c(N)cc1F.[K+]>>N#Cc1cc2sc([S-])nc2cc1F.[K+],,CN(C)C=O,,,,val
US20100216791A1,O=Cc1ccc(Nc2ncc3cc(-c4ccncc4)ccc3n2)cc1>>OCc1ccc(Nc2ncc3cc(-c4ccncc4)ccc3n2)cc1,,CO,,[BH4-].[Na+],,val
US20090264445A1,COC(=O)C(NC(=O)OCc1ccccc1)P(=O)(O)O.O=CC1CC2CCC1C2>>COC(=O)C(=CC1CC2CCC1C2)NC(=O)OCc1ccccc1,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US05807863,COC(=O)Cc1c(C)nc(C)nc1Oc1ccn(Cc2c(Cl)cccc2Cl)n1.COS(=O)(=O)OC.O=CCNCC=O>>COC=C(C(=O)OC)c1c(C)nc(C)nc1Oc1ccn(Cc2c(Cl)cccc2Cl)n1,,CN(C)C=O,,[H-].[Na+],,val
US20100130492A1,CS(=O)(=O)N1CCNCC1.Nc1ncc(-c2nc(N3CCOCC3)c3nc(Cl)n(CC4CCOC4)c3n2)cn1>>CS(=O)(=O)N1CCN(c2nc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3n2CC2CCOC2)CC1,,CS(C)=O,,,,val
US05589478,BrBr.Nc1cc(OCCO)ncn1>>Nc1ncnc(OCCO)c1Br,,CO,,,,val
US20080125449A1,CCCCCCCCCCCCCCCc1cccc(OC)c1C=O.CCOC(=O)CC(C)=O.NC(N)=O>>CCCCCCCCCCCCCCCc1cccc(OC)c1C1NC(=O)NC(C)=C1C(=O)OCC,,C1CCOC1,,Cl,,val
US20100016279A1,CCOC(=O)c1ccc(N2CCNCC2)cc1.FC(F)(F)c1nnc2ccc(Cl)nn12>>CCOC(=O)c1ccc(N2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20150225394A1,CCS(=O)(=O)N1CC(=CC#N)C1.OCC1CCNCC1>>CCS(=O)(=O)N1CC(CC#N)(N2CCC(CO)CC2)C1,,CC#N,ClCCl,C1CCC2=NCCCN2CC1,,val
US20040214798A1,Nc1cc([N+](=O)[O-])ccc1CO.O=P(Cl)(Cl)N(CCCl)CCCl>>O=[N+]([O-])c1ccc2c(c1)NP(=O)(N(CCCl)CCCl)OC2,,CCOC(C)=O,,CCN(CC)CC,,val
US04452851,CS(=O)(=O)Cl.O=C(Cc1ccccc1)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(O)CS(=O)[C@H]12>>CS(=O)(=O)OC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)Cc3ccccc3)[C@H]2S(=O)C1,,c1ccncc1,,O,,val
US05246969,CCOC(=S)C(Cc1ccccc1)CC(C)(C)C>>CC(C)(C)CC(Cc1ccccc1)C(O)=S,,CO,,[K+].[OH-],,val
US04550105,C=CCO/N=C(\C(=O)O)c1csc(NC(=O)CCl)n1.ClCCl.ClP(Cl)(Cl)(Cl)Cl>>C=CCO/N=C(\C(=O)Cl)c1csc(NC(=O)CCl)n1.Cl,,ClCCl,,CCCCCC,,val
US20150266868A1,Cc1nc(CN2CCNCC2)no1.Nc1ncc(Cl)c(Cl)c1[N+](=O)[O-]>>Cc1nc(CN2CCN(c3c(Cl)cnc(N)c3[N+](=O)[O-])CC2)no1,,CC(C)O,,CCN(C(C)C)C(C)C,Cl,val
US20110112080A1,CC(C)(C)OC(=O)N1C(c2ccc(C(=O)O)cc2)COC1(C)C.Nc1ccc(Cl)cc1>>CC(C)(C)OC(=O)N1C(c2ccc(C(=O)Nc3ccc(Cl)cc3)cc2)COC1(C)C,,C1CCOC1,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20080096860A1,Fc1cccc(CSc2nc(Cl)cc(Cl)n2)c1F.OC1COC(c2ccccc2)OC1>>Fc1cccc(CSc2nc(Cl)cc(OC3COC(c4ccccc4)OC3)n2)c1F,,C1CCOC1,O,[H-].[Na+],,val
US20100204226A1,CCOC(=O)c1cnn(-c2nc3cc(-c4ccccc4)ccc3c(=O)[nH]2)c1>>O=C(O)c1cnn(-c2nc3cc(-c4ccccc4)ccc3c(=O)[nH]2)c1,,C1CCOC1,,O,[K+].[OH-],val
US05756769,CC#CCOS(C)(=O)=O.N.O=Cc1ccccc1>>CC#CCN=Cc1ccccc1,,Cc1ccccc1,,,,val
US20130225524A1,N#CCC#N.O=c1[nH]c2cc(Br)ccc2c(=O)o1>>N#CC(C#N)=C(O)c1ccc(Br)cc1N,,CN(C)C=O,O,CCN(CC)CC,Cl,val
US20140024650A1,CCOC(=O)C1CCCCC1N.CCS(=O)(=O)Cl>>CCOC(=O)[C@@H]1CCCC[C@H]1NS(=O)(=O)CC,,CCN(CC)CC,,Cl,,val
US20120065214A1,Cc1c(F)cc(C(=O)NC2CC2)cc1-n1cc(Br)nc(NC(C)(C)c2ccccc2SCCOCc2ccccc2)c1=O>>Cc1c(F)cc(C(=O)NC2CC2)cc1-n1ccnc(NC(C)(C)c2ccccc2SCCOCc2ccccc2)c1=O,[Pd],CCO,,O=C[O-].[NH4+],,val
US06162598,CCCCCCCCCCCCCCCCOC(=O)c1ccc(Cl)c(NC(=O)C(Cl)C(=O)C(C)(C)C)c1.COC(=O)c1ccc(O)c(NS(C)(=O)=O)c1>>CCCCCCCCCCCCCCCCOC(=O)c1ccc(Cl)c(NC(=O)C(Oc2ccc(C(=O)OC)cc2NS(C)(=O)=O)C(=O)C(C)(C)C)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160002224A1,COC(=O)c1cc(Cc2cc3nc(-c4ccc(C5(COC(C)=O)CC5)cc4)c(Cl)cc3[nH]2)ccc1C>>Cc1ccc(Cc2cc3nc(-c4ccc(C5(CO)CC5)cc4)c(Cl)cc3[nH]2)cc1C(=O)O,,CO,,C1CCOC1,[Na+].[OH-],val
US20030149035A1,C#CCN(C)C.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN3CCOCC3)cc(I)c21>>CN(C)CC#Cc1cc(CN2CCOCC2)cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12,[Cu]I,CCNCC,,CN(C)C=O,,val
US20100286146A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C(O)C([NH3+])Cc1ccccc1>>CCOC(=O)C(O)C(Cc1ccccc1)NC(=O)OC(C)(C)C,,C1CCOC1,,CCN(CC)CC,,val
US20130296346A1,CI.Clc1nc(NCCCCC=C(c2ccccc2)c2ccccc2)c2nc[nH]c2n1>>Cn1cnc2c(NCCCCC=C(c3ccccc3)c3ccccc3)nc(Cl)nc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110124618A1,CCOC(=O)c1cc(-c2cccc(F)c2)n(-c2ccc(F)cc2)n1>>O=C(O)c1cc(-c2cccc(F)c2)n(-c2ccc(F)cc2)n1,,C1COCCO1,O,[Li+].[OH-],,val
US20090118287A1,COC(=O)C1(C(=O)OC)CCCC1>>COC(=O)C1(C(=O)O)CCCC1,,CO,,[K+].[OH-],,val
US04501606,C=CCOC(=O)Cl.CC(C)(C)c1cc(N)n[nH]1>>C=CCOC(=O)Nc1cc(C(C)(C)C)[nH]n1,,C1COCCO1,,,,val
US20130072467A1,O=C1N=C(NCCCO)CS1.O=CC1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1>>O=C1N=C(NCCCO)/C(=C/C2CCN(Cc3ccc(C(F)(F)F)cc3C(F)(F)F)CC2)S1,,CC(C)O,,C1CC[NH2+]CC1.CC(=O)[O-],,val
US20110230462A1,BrC1CCCC1.Oc1ccnc(Br)c1>>Brc1cc(OC2CCCC2)ccn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160024077A1,C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OC)c(C)cn3nc(-c4cccc(-c5cc(C)ccc5O)c4)cc23)CC1.C=CC[C@@H](C)O>>C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OC)c(C)cn3nc(-c4cccc(-c5cc(C)ccc5O[C@@H](C)CC=C)c4)cc23)CC1,,C1CCOC1,O,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080214755A1,C=CCC(CO)(CO)CC=C.CC(C)=O.COC(OC)OC>>C=CCC1(CC=C)COC(C)(C)OC1,O=S(=O)(O)O,,,,,val
US20080312226A1,O=C(OCC(Cl)(Cl)Cl)N(C(=O)OCC(Cl)(Cl)Cl)c1cccnc1.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>O=C(Nc1cccnc1)N1CCN(c2nc(-c3ccccc3)ns2)CC1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US04870074,CC(=O)OCCC1CN(C(=O)OCc2ccccc2)CCO1>>O=C(OCc1ccccc1)N1CCOC(CCO)C1,,O,,CCO,[K+].[OH-],val
US20090298807A1,CC(C)(C)[Si](C)(C)O[C@@H](CBr)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12.CC(C)(N)Cc1cccc(CO)c1>>CC(C)(Cc1cccc(CO)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12,,CC#N,,CCN(C(C)C)C(C)C,[I-].[Na+],val
US20070232627A1,CC(C)(C)OC(=O)Nc1ccc(O)cc1.O=C(Nc1ccc(Cl)cn1)c1ccc(Cl)c([N+](=O)[O-])c1>>CC(C)(C)OC(=O)Nc1ccc(Oc2ccc(C(=O)Nc3ccc(Cl)cn3)cc2[N+](=O)[O-])cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100093711A1,COC(=O)c1c[nH]cn1.O=C(c1ccccc1)N1CCC(O)c2ccccc21>>COC(=O)c1cncn1C1CCN(C(=O)c2ccccc2)c2ccccc21,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05112743,CCCCCCCCCCCCOS(=O)(=O)c1ccccc1>>CCCCCCCCCCCCOS(=O)(=O)c1ccccc1,,O,,[Na],,val
US20090298812A1,COc1cc(C)c(S(=O)(=O)Cl)c(C)c1.OCCNC1CC1>>COc1cc(C)c(S(=O)(=O)N(CCO)C2CC2)c(C)c1,,ClCCl,,CCN(CC)CC,,val
US20090131472A1,O=c1ccn2c(-c3ccc(F)cc3)cccc2c1-c1c(F)cc(Br)cc1F.OB(O)c1cncnc1>>O=c1ccn2c(-c3ccc(F)cc3)cccc2c1-c1c(F)cc(-c2cncnc2)cc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20110212053A1,CC(=O)n1nc(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(Br)ccc3ncc21>>CC(C)(C#N)c1ccc(-c2n[nH]c3cnc4ccc(Br)cc4c23)cc1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20040176308A1,CC(C)C(=O)CC(=S)OCc1ccccc1.NNCCO>>CC(C)c1cc(OCc2ccccc2)nn1CCO,,CC#N,,CCN(CC)CC,O,val
US20100087471A1,Cc1ccc(/C=C\n2c3c(c4cc(OC(F)(F)F)ccc42)CN2CCC3CC2)cn1>>CC1CCC(CCn2c3c(c4cc(OC(F)(F)F)ccc42)CN2CCC3CC2)CN1,O=[Pt],CO,,,,val
US05399574,Cl.O=C1N[C@@H](Cc2ccc([N+](=O)[O-])cc2)CO1>>Cl.Nc1ccc(C[C@H]2COC(=O)N2)cc1,[Pd],CCO,CCOC(C)=O,O,[H][H],val
US20130143843A1,CCOC(=O)C(C)(CC(=O)c1ccc(C)cc1)NC(=O)CC(=O)Nc1ccc(OC)cc1.N#CCC(=O)Cl>>CCOC(=O)C(C)(CC(=O)c1ccc(C)cc1)NC(=O)CC#N,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20060264428A1,CI.C[C@H](c1ccccc1)N1C[C@@](CO[Si](C)(C)C(C)(C)C)(C(=O)OC(C)(C)C)CC1=O>>CC1C(=O)N([C@H](C)c2ccccc2)C[C@@]1(CO[Si](C)(C)C(C)(C)C)C(=O)OC(C)(C)C,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20100317693A1,BrCc1ccsc1.CC(=O)NC1Cc2cccc(N3CCCC3=O)c2NC1=O>>CC(=O)NC1Cc2cccc(N3CCCC3=O)c2N(Cc2ccsc2)C1=O,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100093999A1,CC(C)(C)OC(=O)NC1=N[C@@]2(c3cc(Br)ccc3F)CO[C@@H](CF)C[C@H]2CS1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)C1=N[C@@]2(c3cc(Br)ccc3F)CO[C@@H](CF)C[C@H]2CS1,CN(C)c1ccncc1,C1CCOC1,,,,val
US04943574,CC(C)I.On1nnc2ccc(Cn3ccnc3)cc21>>CC(C)On1nnc2ccc(Cn3ccnc3)cc21,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04939143,COC(=O)C1C(c2ccc(F)c(C)c2)=CC2(CC1(C)C)SCCCS2>>Cc1cc(C2=CC3(CC(C)(C)C2CO)SCCCS3)ccc1F,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070155805A1,CCOC(=O)Cc1sc(SCCC(CCOC)c2sc3cc(C(F)(F)F)ccc3c2C)nc1C>>COCCC(CCSc1nc(C)c(CC(=O)O)s1)c1sc2cc(C(F)(F)F)ccc2c1C,,C1CCOC1,CO,[Na+].[OH-],,val
US04849408,CC(C)(O)CC#N.O=C(Cl)Cl>>CC(C)(CC#N)OC(=O)Cl,,ClCCl,,c1ccncc1,,val
US20160024110A1,COc1cccc(Oc2cc(Br)c(F)cc2[N+](=O)[O-])c1>>COc1cccc(Oc2cc(Br)c(F)cc2N)c1,,CCOC(C)=O,,CC(=O)O,O,val
US04891447,COC(C)(C)CCC1CC(=O)C=C(C)C1>>COC(C)(C)CCC1CC(C)=CC(O)C1,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US04973737,Cc1ccccc1.OCc1ccccc1>>c1ccc(COCc2ccccc2)cc1,,Cc1ccccc1,,,,val
US20070265268A1,CCc1c(OCOC)cc(OCOC)c(C(=O)NCc2ccccc2)c1CC(=O)OC>>CCc1c(OCOC)cc(OCOC)c(C(=O)NCc2ccccc2)c1CCO,,C1CCOC1,,[H-].[Na+],,val
US20120232099A1,COCCl.Oc1ccc(OCc2ccccc2)nc1>>COCOc1ccc(OCc2ccccc2)nc1,,CN(C)C=O,,[H-].[Na+],,val
US20090192163A1,COC(=O)C(C)c1ccc(Cl)c(OC)c1>>COC(=O)C(C)c1ccc(Cl)c(O)c1,,CC(=O)O,,Br,,val
US05221671,O=C(Cl)C1CC1.OC1CCNCC1>>O=C(C1CC1)N1CCC(O)CC1,,ClCCl,,CCN(CC)CC,,val
US20070167488A1,CCOC(=O)CCCl.O=Cc1c[nH]c2ccccc12>>CCOC(=O)CCn1cc(C=O)c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20080132503A1,COc1ccc(C(=O)Nc2cc(-c3ccc(CNCCO)s3)ccc2[N+](=O)[O-])cc1>>COc1ccc(C(=O)Nc2cc(-c3ccc(CNCCO)s3)ccc2N)cc1,,ClCCl,,CCN(CC)CC,CO,val
US06218376B1,Cc1nc2c(s1)C=Cc1cc(Cl)ccc1C2O.O=c1cc[nH]c(=O)[nH]1>>Cc1nc2c(s1)C=Cc1cc(Cl)ccc1C2c1c[nH]c(=O)[nH]c1=O,,CC(=O)O,,,,val
US04766215,BrC(c1ccccc1)c1ccccc1.CCC(O)N1CCN(c2ncccn2)CC1>>c1ccc(C(OCCCN2CCN(c3ncccn3)CC2)c2ccccc2)cc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20060111375A1,CCCOC(=O)c1cc2ccccc2cc1Oc1ccnc2cc(O)c(OC)cc12.ClCCCBr>>CCCOC(=O)c1cc2ccccc2cc1Oc1ccnc2cc(OCCCCl)c(OC)cc12,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US07160892B2,CCn1c(N)nc(-c2cccc(F)c2)c(-c2ccc(=O)[nH]c2)c1=O.CI>>CCn1c(N)nc(-c2cccc(F)c2)c(-c2ccc(=O)n(C)c2)c1=O,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04091024,CC(=O)SCC(CC(N)=O)C(=O)O>>CC(=O)SCC(CC#N)C(=O)O,,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20040014962A1,CS(=O)(=O)Cl.NC(=O)c1csc(N2CC[C@@H](O)C2)n1>>CS(=O)(=O)O[C@@H]1CCN(c2nc(C(N)=O)cs2)C1,,ClCCl,,CCN(CC)CC,CO,val
US20110183997A1,CC(=O)c1nccs1.CI.Cc1cc2c(cn1)cc(-c1cc(N=C=S)ccc1C)c(=O)n2C>>CS/C(=C\C(=O)c1nccs1)Nc1ccc(C)c(-c2cc3cnc(C)cc3n(C)c2=O)c1,,CN(C)C=O,,[H-].[Na+],,val
US20100249187A1,Fc1cc(Br)ccc1-c1ccccc1.N#C[Cu]>>N#Cc1ccc(-c2ccccc2)c(F)c1,,c1ccncc1,,[I-].[K+],,val
US20100197660A1,CCN(CC)C1=NC=CC(c2ccccc2)=CC1.O>>O=C1CC=C(c2ccccc2)C=CN1,,COCCO,,,,val
US20150080393A1,CCOC(=O)[C@@H]1CC2(CCN(c3cc(O[C@H](c4ccc(-c5ccc(C)c(C)c5)cc4-n4ccc(C)n4)C(F)(F)F)nc(N)n3)CC2)CN1C(=O)OCc1ccccc1>>CCOC(=O)[C@@H]1CC2(CCN(c3cc(O[C@H](c4ccc(-c5ccc(C)c(C)c5)cc4-n4ccc(C)n4)C(F)(F)F)nc(N)n3)CC2)CN1,[Pd],CCOC(C)=O,,,,val
US05017211,CON(C)C(=O)c1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(F)cc1Cl.COS(=O)(=O)OC>>CON(C)C(=O)c1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20120142717A1,C=Cc1ccc(Oc2cccc(C(F)(F)F)n2)cc1.OO>>OCCc1ccc(Oc2cccc(C(F)(F)F)n2)cc1,,C1CCOC1,,B1C2CCCC1CCC2,[Na+].[OH-],val
US20090054437A1,COc1cc(C2=NOC(O)(c3ccc[n+]([O-])c3C(F)(F)F)C2)cc([N+](=O)[O-])c1OC>>COc1cc(-c2cc(-c3ccc[n+]([O-])c3C(F)(F)F)on2)cc([N+](=O)[O-])c1OC,,CCOC(C)=O,,O=C(O)C(F)(F)F,,val
US20090076004A1,CCOC(=O)Cc1c(C(=O)OCC)c2cc(O)ccc2n1-c1ccc(OC(F)(F)F)cc1.Clc1ccc2c(Cl)ccnc2c1>>CCOC(=O)Cc1c(C(=O)OCC)c2cc(Oc3ccnc4cc(Cl)ccc34)ccc2n1-c1ccc(OC(F)(F)F)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04238496,COc1ccccc1C(C)=O.II.NC(N)=S>>COc1ccccc1-c1csc(N)n1.I,,O,,CO,,val
US04551460,O=C1c2ccccc2C(=O)N1CCCCCCc1cncnc1>>NCCCCCCc1cncnc1,,CCO,,NN,O,val
US20050282827A1,CC(N)(CO)CO.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1>>CC(CO)(CO)NS(=O)(=O)c1cccc([N+](=O)[O-])c1,,C1COCCO1,,CCN(CC)CC,O,val
US20100022601A1,CN.O=S(=O)(Cl)c1ccccc1Br>>CNS(=O)(=O)c1ccccc1Br,,C1CCOC1,,O,,val
US20040019048A1,CCCCc1nc2cnc3ccccc3c2n1CCCN.O=C=Nc1ccccc1>>CCCCc1nc2cnc3ccccc3c2n1CCCNC(=O)Nc1ccccc1,,ClCCl,,,,val
US20100249181A1,Cc1cccc(CN2CCN([C@H](C(=O)OC(C)(C)C)C(C)(C)C)C2=O)c1[N+](=O)[O-]>>Cc1cccc(CN2CCN([C@H](C(=O)O)C(C)(C)C)C2=O)c1[N+](=O)[O-],,ClCCl,,O=C(O)C(F)(F)F,,val
US20050075375A1,BrCc1ccccc1.CC(C)=O.Oc1ccccc1>>c1ccc(COCc2ccccc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090286791A1,CCOC(=O)CBr.CCOc1ccc(C(=O)NCCNC(=O)c2cn(-c3ccccc3O)nc2C(F)(F)F)cc1>>CCOC(=O)COc1ccccc1-n1cc(C(=O)NCCNC(=O)c2ccc(OCC)cc2)c(C(F)(F)F)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05157041,CC(C)(C)N1C[C@H](N=[N+]=[N-])C[C@]1(C(N)=O)C(=O)OCc1ccccc1.N#N>>CC(C)(C)N1C[C@H](N)C[C@]1(C(N)=O)C(=O)OCc1ccccc1.N#N,,C1CCOC1,,,,val
US20100324022A1,CC(C)(C)[Si](C)(C)Cl.COC(=O)[C@]1(CO)CC[C@H](c2ccc(OCc3ccccc3F)cc2)N1C(=O)OCc1ccccc1>>COC(=O)[C@]1(CO[Si](C)(C)C(C)(C)C)CC[C@H](c2ccc(OCc3ccccc3F)cc2)N1C(=O)OCc1ccccc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20080139639A1,CN(Cc1cc(Br)n(S(=O)(=O)c2ccc(F)cc2)c1)C(=O)OC(C)(C)C.OB(O)c1ccsc1>>CN(Cc1cc(-c2ccsc2)n(S(=O)(=O)c2ccc(F)cc2)c1)C(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20110224190A1,CN(C)c1ccc(CN2CCC(N3CC(CC#N)(n4cc(-c5ncnc6c5ccn6COCC[Si](C)(C)C)cn4)C3)CC2)c(F)c1C#N>>CN(C)c1ccc(CN2CCC(N3CC(CC#N)(n4cc(-c5ncnc6[nH]ccc56)cn4)C3)CC2)c(F)c1C#N,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080304867A1,C1CCOC1.CCCCCC.COB(OC)OC.Cc1cc(C)c(Br)c(C)c1.Cc1ccc(N)c(C)c1>>Cc1ccc(N(c2ccc(B(O)O)cc2)c2c(C)cc(C)cc2C)c(C)c1,,C1CCOC1,,Cl,[Li]CCCC,val
US20150376233A1,C=CCCC(C)C[C@@H](COC)[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)O.C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)C1CC1>>C=CCCC(C)C[C@@H](COC)[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@]1(C(=O)NS(=O)(=O)C2CC2)C[C@H]1C=C,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05686458,COc1cccc2c(N3CCc4cc(C)ccc4C3C)nc(Cl)nc12.Cc1cc(F)ccc1N>>COc1cccc2c(N3CCc4cc(C)ccc4C3C)nc(Nc3ccc(F)cc3C)nc12.Cl,,CN(C)C=O,,,,val
US20140323558A1,COC(=O)C#N.COc1ccc(-c2cccc(C(F)(F)F)c2)c2c1C(=O)CC2>>COC(=O)C1Cc2c(-c3cccc(C(F)(F)F)c3)ccc(OC)c2C1=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US05932590,CC(C)(C)OC(=O)N1Cc2ccccc2C[C@H]1C(=O)NCCc1cncn1Cc1ccc(C#N)cc1.O=C(O)C(F)(F)F>>N#Cc1ccc(Cn2cncc2CCNC(=O)[C@@H]2Cc3ccccc3CN2)cc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20030199493A1,CC(=O)OCCCCCC(=O)C1Cc2cccc3c2N(C1)C(=O)C3>>O=C(CCCCCO)C1Cc2cccc3c2N(C1)C(=O)C3,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20150183824A1,NCc1ccccc1.O=CCC1CCC1>>C(CC1CCC1)=NCc1ccccc1,,ClCCl,,,,val
US20080004309A1,CCOC(=O)c1sc(-c2ccccc2)nc1C.O=C1CCC(=O)N1Br>>CCOC(=O)c1sc(-c2ccccc2)nc1CBr,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US04436748,COc1cc2cc(-c3ccccc3F)sc2c(Cl)c1Cl>>Oc1cc2cc(-c3ccccc3F)sc2c(Cl)c1Cl,,O,,Cl,c1ccncc1,val
US20110034507A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1CCl.COC(=O)c1ccc(-c2ccc3cc(O)ccc3c2)nc1>>COC(=O)c1ccc(-c2ccc3cc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)ccc3c2)nc1,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20040122002A1,O=CCCl.c1ccc(CC2=NCCC2)cc1>>c1ccc(-c2ccn3c2CCC3)cc1,,CO,,O=C([O-])O.[Na+],,val
US20080021026A1,COc1cc(C(=O)O)cc(OC)c1OC.Cc1c(-c2ccnc(N)n2)sc2ccc(N=C(c3ccccc3)c3ccccc3)cc12>>COc1cc(C(=O)Nc2ccc3sc(-c4ccnc(N)n4)c(C)c3c2)cc(OC)c1OC,,O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100130470A1,CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccnc1N>>O=C1N[C@@H](Cc2ccccc2)C(=O)Nc2ncccc21,,O,,C1CCOC1,[H-].[Na+],val
US20070078164A1,COCCCOS(=O)(=O)c1ccc(C)cc1.O=Cc1ccccc1O>>COCCCOc1ccccc1C=O.Cc1ccc(S(=O)(=O)[O-])cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120040954A1,COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCNCC4)cc3)nc2c1.Fc1ccc(CBr)cc1>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCN(Cc5ccc(F)cc5)CC4)cc3)nc2c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20080234237A1,CC(C)(C)OC(=O)N1CCC(N2CCc3ccccc32)C1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCC(N2CCc3cc(Br)ccc32)C1,,CN(C)C=O,O,,,val
US20040097563A1,COc1ccc(COc2ccccc2-c2cc(-c3ccc([N+](=O)[O-])c(OCCN4CCCCC4)c3)c(C#N)c(N)n2)cc1>>COc1ccc(COc2ccccc2-c2cc(-c3ccc(N)c(OCCN4CCCCC4)c3)c(C#N)c(N)n2)cc1,,CN(C)C=O,,Cl[Sn]Cl,,val
US20090156642A1,O=Cc1cc(-c2cccnc2F)c(Br)s1.Sc1ccsc1>>O=Cc1cc(-c2cccnc2F)c(Sc2ccsc2)s1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US06479504B1,CC(C)(C)Oc1cc(-c2ccc3ccccc3c2)nc2ccccc12.Cc1ccc(S(=O)(=O)O)cc1>>Cc1ccc(S(=O)(=O)[O-])cc1.Oc1cc(-c2ccc3ccccc3c2)[nH+]c2ccccc12,,C1CCOC1,,,,val
US20150266824A1,CC(C)(C)OC(=O)N1C[C@H](C2CCCCC2)C[C@H]1C=O>>CC(C)(C)OC(=O)N1C[C@H](C2CCCCC2)C[C@@H]1C=O,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US06274578B1,COC(=O)COc1cccc2c1c(C(=O)C(N)=O)c(C)n2Cc1ccccc1>>Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1,,CO,,CCOC(C)=O,[Na+].[OH-],val
US20060063779A1,CC(C)(C)OC(=O)c1ccc(CS(C)(=O)=O)cc1Cl>>CS(=O)(=O)Cc1ccc(C(=O)O)c(Cl)c1,,C1COCCO1,,Cl,,val
US20130017194A1,CC(C)(C)OC(=O)N1CC=C(c2ccc([N+](=O)[O-])cc2)CC1>>CC(C)(C)OC(=O)N1CCC(c2ccc(N)cc2)CC1,[Pd],CCO,CN(C)C=O,,,val
US20060127990A1,COc1ccc(C(OC[C@H]2S[C@@H](n3ccc(=O)[nH]c3=O)C[C@@H]2OC(C)=O)(c2ccccc2)c2ccc(OC)cc2)cc1>>CC(=O)O[C@H]1C[C@H](n2ccc(=O)[nH]c2=O)S[C@@H]1CO,,CCOC(C)=O,,ClCCl,O=C(O)C(F)(F)F,val
US20090239846A1,Cc1ccc(C(=O)NC(C)C)cc1-c1nc(NCCN(C)C(=O)OC(C)(C)C)nc2c1CNC(=O)N2c1c(F)cccc1F>>CNCCNc1nc(-c2cc(C(=O)NC(C)C)ccc2C)c2c(n1)N(c1c(F)cccc1F)C(=O)NC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030027815A1,CN1CCNCC1.COC(=O)c1ccc2c(c1)N(C(=O)c1ccc(C3CCCCC3)cc1)Cc1cccn1C2.ClCCl.O=C(Cl)OC(Cl)(Cl)Cl>>COC(=O)c1ccc2c(c1)N(C(=O)c1ccc(C3CCCCC3)cc1)Cc1ccc(C(=O)N3CCN(C)CC3)n1C2.Cl,,ClCCl,,CCN(CC)CC,,val
US20160243100A1,CC(C)(C)OC(=O)N1CCC(CS(=O)(=O)c2cccc(F)c2)CC1.CI>>CC(C1CCN(C(=O)OC(C)(C)C)CC1)S(=O)(=O)c1cccc(F)c1,,C1CCOC1,O,CC(C)[N-]C(C)C.[Li+],,val
US20060100425A1,CC(C)(C)OC(=O)CBr.O=S1(=O)N=C(c2c[nH]c3ccccc23)c2ccccc21>>CC(C)(C)OC(=O)Cn1cc(C2=NS(=O)(=O)c3ccccc32)c2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090239854A1,C=Cc1ccc(C)cc1.CCN1CCc2[nH]c3ccc(C)cc3c2C1>>CCN1CCc2c(c3cc(C)ccc3n2CCc2ccc(C)cc2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20110224274A1,Cc1ccc(CN2C(=O)c3ccccc3C2(O)c2ccc(Cl)cc2)cc1.O=S(Cl)Cl>>Cc1ccc(CN2C(=O)c3ccccc3C2(Cl)c2ccc(Cl)cc2)cc1,CN(C)C=O,,,,,val
US05114949,COC1c2ccccc2C(=O)N1CCBr.Fc1ccc2[nH]cc(CC3CCNCC3)c2c1>>COC1c2ccccc2C(=O)N1CCN1CCC(Cc2c[nH]c3ccc(F)cc23)CC1,,C1CCOC1,CN(C)C=O,O=C([O-])O.[Na+],,val
US20160200716A1,CC(=O)O.CC(C)c1nc(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)cs1>>CC(=O)[O-].CC(C)c1nc(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)cs1,,CCCCCCC,,CCOC(C)=O,,val
US20040106621A1,C[C@H](N)c1cccc(Br)c1.c1nc[nH]n1>>C[C@H](N)c1cccc(-n2cncn2)c1,[Cu]I,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20120322837A1,CC(C)(C)CC1CC(c2onc(C(CCCOCc3ccccc3)CC(=O)OC(C)(C)C)c2C2CC2)C1>>CC(C)(C)CC1CC(c2onc(C(CCCO)CC(=O)OC(C)(C)C)c2C2CC2)C1,[Pd],C1CCOC1,,CO,,val
US20020123497A1,CC(C)(C)OC(=O)N1CCNC(=O)C1.CS(=O)(=O)Oc1ccc(Cl)c(CBr)c1>>CC(C)(C)OC(=O)N1CCN(Cc2cc(OS(C)(=O)=O)ccc2Cl)C(=O)C1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US05574058,BrCc1ccccc1.Clc1nc2cc(Cl)c(Cl)cc2[nH]1>>Clc1cc2nc(Cl)n(Cc3ccccc3)c2cc1Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04086348,CCN(CC)C(=O)Cl.O=C1c2ccccc2C(O)N1c1ccc2ccc(Cl)nc2n1>>CCN(CC)C(=O)OC1c2ccccc2C(=O)N1c1ccc2ccc(Cl)nc2n1,,ClCCl,O,CCN(CC)CC,c1ccncc1,val
US20100249099A1,COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N(CCCN(C)C)C2CCCN(S(C)(=O)=O)C2)n1.Cl>>COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N(CCCN(C)C)C2CCCN(S(C)(=O)=O)C2)n1.Cl,,CO,,,,val
US06034248,CCOC(CN)OCC.O=C(Nc1ccc(-n2cncn2)cc1)Oc1ccccc1>>CCOC(CNC(=O)Nc1ccc(-n2cncn2)cc1)OCC,,c1ccncc1,,,,val
US20090274632A1,COc1ccc(CN)cc1.O=C(O)c1ccc(S(=O)(=O)Cl)cc1>>COc1ccc(CNS(=O)(=O)c2ccc(C(=O)O)cc2)cc1,,CC(C)=O,,CCN(CC)CC,,val
US20110152273A1,CC(C)(C)OC(=O)N[C@H]1COCC[C@H]1Nc1nc(-c2cccs2)c2c(c1F)CN(C(=O)OC(C)(C)C)C2=O>>N[C@H]1COCC[C@H]1Nc1nc(-c2cccs2)c2c(c1F)CNC2=O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20120157404A1,COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)[nH]1)C(C)(C)S(C)(=O)=O.COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc(Br)cc2)[nH]1)C(C)C>>COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc(-c3ccc(-c4cnc(C5CCCN5C(=O)C(NC(=O)OC)C(C)(C)S(C)(=O)=O)[nH]4)cc3)cc2)[nH]1)C(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])O.[Na+],,val
US20080096861A1,CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21.ClCc1cccnc1>>CN(Cc1nc2ccccc2n1Cc1cccnc1)C1CCCc2cccnc21,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US05085689,CC(=O)C1C(=O)CC(C=O)CC1=O.NOS(=O)(=O)O>>CC(=O)C1C(=O)CC(C#N)CC1=O,,O,,,,val
US20040248931A1,CI.C[C@H]1C[C@H](C(=O)O)N(C(=O)OC(C)(C)C)C1>>COC(=O)[C@H]1C[C@H](C)CN1C(=O)OC(C)(C)C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120329808A1,CC(C)(C)[Si](C)(C)Cl.N#CC(CO)c1ccc(Cl)cc1>>CC(C)(C)[Si](C)(C)OCC(C#N)c1ccc(Cl)cc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20120028990A1,CC(C)(C)OC(=O)N1CCCCC1=O.c1ccoc1>>CC(C)(C)OC(=O)NCCCCC(=O)c1ccco1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20050256037A1,CC(C)(C)OC(=O)NCCC[C@@H](CO)NC(=O)OC(C)(C)C.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)NCCC[C@@H](COS(C)(=O)=O)NC(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20110130398A1,COc1cc(N(C)C)ccc1[N+](=O)[O-]>>COc1cc(N)ccc1N(C)C,[Pd],,,CCOC(C)=O,,val
US20160221972A1,CC(C)(C)OC(=O)NCCO.COC(=O)c1ccc(C(=O)OC)c(O)c1>>COC(=O)c1ccc(C(=O)OC)c(OCCNC(=O)OC(C)(C)C)c1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150274777A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccccn1)C(=O)O.CO>>COC(=O)[C@H](Cc1ccccn1)NC(=O)OC(C)(C)C,,CO,,C[Si](C)(C)C=[N+]=[N-],,val
US07045545B1,COC(=O)c1cc(CC(C)NC(=O)OC(C)(C)C)c2occc2c1>>CC(Cc1cc(C(=O)O)cc2ccoc12)NC(=O)OC(C)(C)C,,CCO,O,[Na+].[OH-],,val
US20110269738A1,CCc1c(C=O)cccc1-c1nnc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)s1.COC(=O)CC1CNC1>>CCc1c(CN2CC(C(=O)OC)C2)cccc1-c1nnc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)s1,,CO,,CC(=O)O,CC(=O)[O-].[Na+],val
US08178668B2,Brc1ccc(Nc2cc3ccccc3o2)nc1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>Cn1cc(-c2ccc(Nc3cc4ccccc4o3)nc2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20120157479A1,C=CCN(CC=C)C(=O)OCc1ccccc1>>O=C(OCc1ccccc1)N1CC=CC1,,ClCCl,,,,val
US20120088750A1,CCOC(=O)C1(C)CCN(c2ncc(B3OC(C)(C)C(C)(C)O3)cn2)CC1.Nc1nc2cc(Cl)cc(-n3cccn3)n2n1>>CCOC(=O)C1(C)CCN(c2ncc(-c3cc(-n4cccn4)n4nc(N)nc4c3)cn2)CC1,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04538627,CC1CCC(=O)C1=O.C[Si](C)(C)C(C(N)=O)[Si](C)(C)C>>CC1=C(O[Si](C)(C)C)C(=O)CC1,,CC#N,,CCCCCC,,val
US20070060587A1,COC(=O)c1csc(Br)c1.OB(O)c1ccccc1>>COC(=O)c1csc(-c2ccccc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20100173933A1,BrB(Br)Br.Brc1ccc2nc(COCc3ccccc3)sc2n1>>BrCc1nc2ccc(Br)nc2s1,,O=C([O-])O,[Na+],,,val
US20120095048A1,CCOC(=O)Cl.c1ccc2[nH]ccc2c1>>CCOC(=O)n1ccc2ccccc21,,C1CCOC1,,[H-].[Na+],,val
US20030072740A1,CC(=O)Oc1ccccc1C(=O)Cl.CC(C(=O)O)c1ccc(N)cc1>>CC(C(=O)O)c1ccc(NC(=O)c2ccccc2O)cc1,,ClCCl,,CCN(CC)CC,C[Si](C)(C)Cl,val
US20060173018A1,COc1ccccc1-c1nc(Cl)c2cc(Br)ccc2n1>>Oc1ccccc1-c1nc(Cl)c2cc(Br)ccc2n1,,ClCCl,,BrB(Br)Br,,val
US20120108583A1,CC1(C)Cc2c(c(C(=O)Nc3ccc(Br)cc3)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1.Cl>>CC1(C)Cc2c(c(C(=O)Nc3ccc(Br)cc3)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1.Cl,,C1CCOC1,,,,val
US20120277220A1,CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(N4CCN(C5CC5)CC4)cc3OC(F)F)nc21.Cl>>CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(N4CCN(C5CC5)CC4)cc3OC(F)F)nc21.Cl,,C1COCCO1,CCOCC,,,val
US20090163469A1,COC=CC(=O)C=C(O)C1(C)CC1>>CC1(c2cc(=O)cco2)CC1,,Cc1ccccc1,,O=C(O)C(F)(F)F,,val
US20080269335A1,CCOC(=O)COc1ccc(-c2ccc(F)c(F)c2)cc1C1CCCCC1>>O=C(O)COc1ccc(-c2ccc(F)c(F)c2)cc1C1CCCCC1,,C1COCCO1,O,Cl,[Na+].[OH-],val
US06177452B1,BrBr.CCOC(=O)CCCCCC(=O)c1ccc(Cl)cc1>>CCOC(=O)CCCCC(Br)C(=O)c1ccc(Cl)cc1,,ClCCl,,,,val
US20130023526A1,Cc1nc(Cl)cc(Cl)n1.O=S(=O)(O)O>>Cc1nc(O)cc(Cl)n1,,[Na+],[OH-],,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccccn3)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3ccccn3)c2)=C(C)C1=O,,CO,O,O=C([O-])O.[Na+],,val
US20100261687A1,Cn1nnnc1-c1cc(Br)cc([N+](=O)[O-])c1>>Cn1nnnc1-c1cc(N)cc(Br)c1,[Ni],CCOC(C)=O,,,,val
US04968804,NC(=O)c1ccnc(-c2cc(C(N)=O)ccn2)c1>>N#Cc1ccnc(-c2cc(C#N)ccn2)c1,,ClCCl,c1ccncc1,O=S(Cl)Cl,,val
US20060211709A1,COC(=O)C1C(N)=NC=C(c2cccc(CCl)c2)N1C.OCc1ccccc1>>COC(=O)c1nc(-c2cccc(COCc3ccccc3)c2)cnc1N,O=[Ag],,,,,val
US20100310512A1,CC(C)(C)OC(=O)N1CC(O)CC1c1nc(-c2ccc(Br)cc2)cn1COCC[Si](C)(C)C.COCCBr>>COCCOC1CC(c2nc(-c3ccc(Br)cc3)cn2COCC[Si](C)(C)C)N(C(=O)OC(C)(C)C)C1,,CN(C)C=O,,[H-].[Na+],,val
US20080045509A1,CCOC1(O[Si](C)(C)C)CC1.CNCCNC(=O)c1ccc(CN(C)C)c(Oc2cccnc2)c1>>CN(C)Cc1ccc(C(=O)NCCN(C)C2CC2)cc1Oc1cccnc1,,C1CCOC1,CO,CC(=O)O,[BH3-]C#N.[Na+],val
US20060167001A1,COc1ccc(C2=NN(C3CCNCC3)C(=O)CC2C)cc1OC.O=C(Cl)CCl>>COc1ccc(C2=NN(C3CCN(C(=O)CCl)CC3)C(=O)CC2)cc1OC,,ClCCl,,CCN(CC)CC,Cl,val
US20150307497A1,C[Si](C)(C)C(F)(F)F.O=Cc1ccc(OCc2ccccc2)c(F)c1>>OC(c1ccc(OCc2ccccc2)c(F)c1)C(F)(F)F,,C1CCOC1,,,,val
US20090182023A1,CC(=O)NCCC1CCc2ccc3nc(C)sc3c21>>CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21,,CCCCCC,CCO,,,val
US20070149525A1,C=C(CCCO)c1cccc(C#N)c1.O=C1CCC(=O)N1I>>N#Cc1cccc(C2(CI)CCCO2)c1,,CCOCC,,,,val
US20110311461A1,O=C(O)C(NCc1ccccc1)c1csc2ccccc12.O[C@H]1CN2CCC1CC2>>O=C(O[C@H]1CN2CCC1CC2)C(NCc1ccccc1)c1csc2ccccc12,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20160039838A1,C1CCC2OCCNC2C1.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CBr>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCOC2CCCCC21,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,O,val
US20100075948A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.CC(C)(C)[Si](C)(C)OCC(=O)c1ccc(N)cc1>>CC(C)(C)CC1NC(C(=O)Nc2ccc(C(=O)CO)cc2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F,,ClCCl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060094904A1,Cc1ccc(OCc2ccccc2)c(-c2c(C)ccc(S(=O)(=O)[O-])c2CCCc2ccccc2)c1.Cc1ccc(OCc2ccccc2)c(C(CCNC(C)C)c2ccccc2)c1>>Cc1ccc(OCc2ccccc2)c(C(CCN(CCC(c2ccccc2)c2cc(C)ccc2OCc2ccccc2)C(C)C)c2ccccc2)c1,,CS(C)=O,,O,,val
US20070105904A1,Brc1ccc(C2OCCCO2)cc1.c1ccc(CSSCc2ccccc2)cc1>>c1ccc(CSc2ccc(C3OCCO3)cc2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20040063775A1,COC(=O)Cc1cn(-c2ccccc2)nc1O.Cc1oc(-c2ccccc2)nc1COc1ccc(CCl)cc1>>COC(=O)Cc1cn(-c2ccccc2)nc1OCc1ccc(OCc2nc(-c3ccccc3)oc2C)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050250810A1,CN.Cn1nc(C(=O)[O-])c2ccccc21>>CNC(=O)c1nn(C)c2ccccc12,,CO,,,,val
US20120059030A1,COc1cc(-c2nnc3n2CCCC3(CO)c2ccc(Cl)c(Cl)c2)ccc1-c1cnc(C)o1.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1cc(-c2nnc3n2CCCC3(COS(=O)(=O)c2ccc(C)cc2)c2ccc(Cl)c(Cl)c2)ccc1-c1cnc(C)o1,,c1ccncc1,,O,,val
US20100292239A1,CC(N)COc1c(Br)cc(Br)cc1Br.Cn1cc(C(=O)O)c(C(F)F)n1>>CC(COc1c(Br)cc(Br)cc1Br)NC(=O)c1cn(C)nc1C(F)F,,O,c1ccncc1,O=P(Cl)(Cl)Cl,,val
US06727277B1,CC(C)(C)[Si](C)(C)Cl.CC(C)(C)[Si](C)(C)Oc1cc(O)c(Br)c(Cl)c1O[Si](C)(C)C(C)(C)C>>CC(C)(C)[Si](C)(C)Oc1cc(O[Si](C)(C)C(C)(C)C)c(O[Si](C)(C)C(C)(C)C)c(Cl)c1Br,CN(C)c1ccncc1,ClCCl,O,CCN(CC)CC,,val
US20110028442A1,O=CNc1cc([C@@H](O)CNCCc2cccc(NC(=O)Nc3ccccc3-c3ccccc3)c2)ccc1OCc1ccccc1>>O=CNc1cc([C@@H](O)CNCCc2cccc(NC(=O)Nc3ccccc3-c3ccccc3)c2)ccc1O,[Pd],CO,,,,val
US20090054460A1,COC(=O)c1ccc2c(c1)CCCC2=O>>COC(=O)c1ccc2c(c1)CCC[C@@H]2O,,C1CCOC1,Cc1ccccc1,CO,,val
US04931452,CO.FC(F)(F)c1cnc(Cl)c(Br)c1>>COc1ncc(C(F)(F)F)cc1Br,,CO,,C[O-].[Na+],,val
US20140329876A1,Cc1c(/C=N/N2CC[C@H](O[Si](C)(C)C(C)(C)C)[C@H]2CO)ccc(C#N)c1Cl>>Cc1c(/C=N/N2CC[C@H](O[Si](C)(C)C(C)(C)C)[C@H]2C=O)ccc(C#N)c1Cl,,ClCCl,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US20130079323A1,CCc1cc2c(O)nc(Cc3cccnc3)nc2[nH]1.O=P(Cl)(Cl)Cl>>CCc1cc2c(Cl)nc(Cc3cccnc3)nc2[nH]1,,CCN(C(C)C)C(C)C,,,,val
US20140249199A1,C[C@@H](C=O)O[Si](C)(C)C(C)(C)C.c1ccoc1>>C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)c1ccco1,,C1CCOC1,,[Li]CCCC,,val
US20150025056A1,COC(=O)Cl.COC(=O)[C@H]1C[C@H](OC)CN[C@@H]1C(=O)N1CCN(c2ccccc2)CC1>>COC(=O)[C@H]1C[C@H](OC)CN(C(=O)OC)[C@@H]1C(=O)N1CCN(c2ccccc2)CC1,CN(C)c1ccncc1,,,ClCCl,,val
US05021478,COC(=O)CCc1cc(-n2nc3ccccc3n2)c(O)c(C(C)(C)C)c1.CON1C(C)(C)CC(O)CC1(C)C>>CON1C(C)(C)CC(OC(=O)CCc2cc(-n3nc4ccccc4n3)c(O)c(C(C)(C)C)c2)CC1(C)C,,Cc1ccccc1C,,,,val
US20020045761A1,CN(C)C=NS(=O)(=O)c1ccccc1-c1ccc(CBr)cc1.O=Cc1[nH]c(-c2ccccc2)nc1Cl>>CN(C)C=NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(-c3ccccc3)nc(Cl)c2C=O)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070270418A1,Nc1ncco1.O=C(CBr)c1ccc(F)cc1>>Br.N=c1occn1CC(=O)c1ccc(F)cc1,,C1CCOC1,CC#N,,,val
US20140350050A1,CCNc1ncc(-c2cnn(C3CCN(C(=O)OC(C)(C)C)CC3)c2)cc1OC(C)c1c(Cl)ccc(F)c1Cl>>CCNc1ncc(-c2cnn(C3CCNCC3)c2)cc1OC(C)c1c(Cl)ccc(F)c1Cl,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20090306063A1,COC(=O)[C@@H]1Cc2cc([N+](=O)[O-])c(O)cc2CN1C(=O)OC(C)C>>COC(=O)[C@@H]1Cc2cc(N)c(O)cc2CN1C(=O)OC(C)C,[Pd],CO,,,,val
US20150291623A1,BrCc1ccc(Br)cc1.O=C1Nc2ccccc2C12COc1cc3c(cc12)CCO3>>O=C1N(Cc2ccc(Br)cc2)c2ccccc2C12COc1cc3c(cc12)CCO3,,CCC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070072847A1,Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCC(C(=O)O)CC3)CC2)cc(C)c1OCc1ccccc1>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCC(C(=O)O)CC3)CC2)cc(C)c1O,[Pd],CO,,[H][H],,val
US20060116410A1,COC(=O)c1cc(O)cc(Cl)c1.ClCc1cc(Cl)cc(Cl)c1>>COC(=O)c1cc(Cl)cc(OCc2cc(Cl)cc(Cl)c2)c1,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130029954A1,C=C(C)[C@@H]1CC[C@]2(CN3CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC(C)(C)C)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CS(=O)(=O)N1CCNCC1>>C=C(C)[C@@H]1CC[C@]2(CNCCN3CCN(S(C)(=O)=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC(C)(C)C)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,CC(C)=O,,,,val
US20160002175A1,NCCC1CCN(Cc2ccccc2)CC1.Nc1nc(Cl)cc(-c2cccc(Cl)c2Cl)n1>>Nc1nc(NCCC2CCN(Cc3ccccc3)CC2)cc(-c2cccc(Cl)c2Cl)n1,,CCCCO,,CCN(CC)CC,,val
US04267174,Cc1ccc(C(=O)NCC(=O)O)cc1.N#CC1CN1>>Cc1ccc(C(=O)NCC(=O)N2CC2C#N)cc1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US06096780,CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.CNC.ClCCCl.O>>CN(C)C1CCC(=O)CC1,,O,,Cl,Cl,val
US20120208798A1,CC(=O)N1c2ccc(Br)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.OB(O)c1ccn[nH]1>>CC(=O)N1c2ccc(-c3ccn[nH]3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US04556672,NC(=O)N1C(=O)Cc2cc([N+](=O)[O-])ccc21>>NC(=O)N1C(=O)Cc2cc(N)ccc21,[Pd],CN(C)C=O,,[H][H],,val
US20080255114A1,O=C(O)[C@@H](CO)N(Cc1ccccc1)C(=O)CCl>>O=C(O)[C@H]1COCC(=O)N1Cc1ccccc1,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20080176829A1,C=O.CC(C)C1NCCOc2ccc3c(ccn3S(=O)(=O)c3ccccc3)c21>>CC(C)C1c2c(ccc3c2ccn3S(=O)(=O)c2ccccc2)OCCN1C,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100041645A1,C=CC#N.COc1ccc(C(=O)NCc2cccc(C(=O)Nc3ccc4c(c3)CNCC4)c2)cc1OC>>COc1ccc(C(=O)NCc2cccc(C(=O)Nc3ccc4c(c3)CN(CCC#N)CC4)c2)cc1OC,,Cc1ccccc1,,,,val
US20150051214A1,COC(=O)c1cc([N+](=O)[O-])c(N2CCN(C(=O)OC(C)(C)C)[C@H](C(C)C)C2=O)cc1S(C)(=O)=O>>COC(=O)c1cc(N)c(N2CCN(C(=O)OC(C)(C)C)[C@H](C(C)C)C2=O)cc1S(C)(=O)=O,[Ni],C1CCOC1,CO,,,val
US20130303533A1,NNC1CCOCC1.O=Cc1c(Cl)nc(Cl)nc1Cl>>Clc1nc(Cl)c2cnn(C3CCOCC3)c2n1,,CCO,,Cl,,val
US20070135594A1,CC1=C(C)C([Si](C)(C)Cl)C(C)=C1C.Cc1cc(Br)cc(C)c1N>>CC1=C(C)C([Si](C)(C)Nc2c(C)cc(Br)cc2C)C(C)=C1C,,C1CCOC1,,[Li]CCCC,,val
US20160002177A1,Cc1cc(C(=O)N2CCCCC2)sc1-c1cc(OCOCC[Si](C)(C)C)c2ncn(COCC[Si](C)(C)C)c(=O)c2c1>>Cc1cc(C(=O)N2CCCCC2)sc1-c1cc(O)c2nc[nH]c(=O)c2c1,,O=CO,,O,,val
US20070219235A1,Nc1cc(Cl)c(C(=O)Nc2ccc3cn[nH]c3c2)cc1[N+](=O)[O-].c1c[nH]cn1>>Nc1cc(-n2ccnc2)c(C(=O)Nc2ccc3cn[nH]c3c2)cc1[N+](=O)[O-],,CN1CCCC1=O,O,,,val
US04303655,CCC(C)(C)OC(=O)Nc1nc(C(=O)C(=O)NC2C(=O)N3C(C(=O)O)=C(CSc4nnc(C)s4)CS[C@H]23)cs1>>Cc1nnc(SCC2=C(C(=O)O)N3C(=O)C(NC(=O)C(=O)c4csc(N)n4)[C@H]3SC2)s1,,O=CO,,,,val
US20070149514A1,Brc1ccc2[nH]cc(-c3nccs3)c2c1.CCOC(=O)COc1ccc(S(=O)(=O)Cl)cc1C>>CCOC(=O)COc1ccc(S(=O)(=O)n2cc(-c3nccs3)c3cc(Br)ccc32)cc1C,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20010036944A1,COc1cc(Br)cc(C=O)c1O>>O=Cc1cc(Br)cc(O)c1O,,ClCCl,,BrB(Br)Br,,val
US20140128611A1,COC(=O)C1(Cc2ccc(Cl)cc2)CCC(C)(CO)C1=O.CS(=O)(=O)Cl>>COC(=O)C1(Cc2ccc(Cl)cc2)CCC(C)(COS(C)(=O)=O)C1=O,,ClCCl,,CCN(CC)CC,O,val
US06329380B1,CC(Nc1nccc(-n2cnc3ccccc32)n1)C1CCCNC1.COP(=O)(Cl)OC>>COP(=O)(OC)N1CCCC(C(C)Nc2nccc(-n3cnc4ccccc43)n2)C1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20140080808A1,CC(C)(C)[Si](C)(C)OC[C@@]1(C)Cc2nnc(C3(c4ccc(-c5cccnc5)cc4)CC3)n2CCS1>>C[C@]1(CO)Cc2nnc(C3(c4ccc(-c5cccnc5)cc4)CC3)n2CCS1,,C1COCCO1,CO,Cl,,val
US20110053905A1,COC(=O)c1c[nH]c(B2OC(C)(C)C(C)(C)O2)c1.Cc1ccc(F)c(NC(=O)c2ccc(F)c(Oc3ccnc(Cl)c3)c2)c1>>COC(=O)c1c[nH]c(-c2cc(Oc3cc(C(=O)Nc4cc(C)ccc4F)ccc3F)ccn2)c1,,C1COCCO1,O,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20090192156A1,CI.O=C1OCc2c(O)cccc21>>COc1cccc2c1COC2=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130150343A1,CS(=O)(=O)Cl.C[C@H]1COCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCO)c4)c4ccccc43)cn12>>C[C@H]1COCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCOS(C)(=O)=O)c4)c4ccccc43)cn12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090093483A1,N#CCc1c(Cl)cccc1I.O=S(=O)(O)O>>O=C(O)Cc1c(Cl)cccc1I,,O,,C1COCCO1,,val
US04931450,Cc1ccccc1Br.Cn1cccc1C(=O)C1CC1>>Cc1ccccc1C(O)(c1cccn1C)C1CC1,,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US20100047367A1,COC(=O)c1cc(Cl)c(Cl)n1N1C(=O)c2ccccc2C1=O>>COC(=O)c1cc(Cl)c(Cl)n1N,,CCO,,NN,O,val
US20130059835A1,CCOc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C#N)c1C1CNC1.C[C@H]1CO1>>CCOc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C#N)c1C1CN(C[C@H](C)O)C1,,CCO,CO,,,val
US06069157,N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1-c1ccoc1>>N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)cc1-c1ccoc1,,C1CCOC1,,CC(C)(C)ON=O,,val
US20100113547A1,C#CCN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(COCC=C)c1ccc(F)cc1>>C#CCN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(CO)c1ccc(F)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US06413974B1,Clc1nc(Cl)c2ncn(C3CCCC3)c2n1.NCCCN1CCOCC1>>Clc1nc(NCCCN2CCOCC2)c2ncn(C3CCCC3)c2n1,,CCN(CC)CC,,,,val
US20080207634A1,CNC1CCOc2cccnc21.Fc1cccc2nc(CCl)cn12>>CN(Cc1cn2c(F)cccc2n1)C1CCOc2cccnc21,,CC#N,CCOC(C)=O,CCN(C(C)C)C(C)C,[I-].[K+],val
US20090124656A1,CCOC(=O)C(Cc1ccc(OCCN2CCC(C)(C)c3cc(C(=NOC)c4ccccc4)ccc32)cc1)OCC(F)(F)F>>CON=C(c1ccccc1)c1ccc2c(c1)C(C)(C)CCN2CCOc1ccc(CC(OCC(F)(F)F)C(=O)O)cc1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20070078169A1,Brc1cccc(Br)n1.CN(C)C1CCC(=O)CC1>>CN(C)C1CCC(O)(c2cccc(Br)n2)CC1,,ClCCl,,[Li]CCCC,,val
US20120165318A1,COC(=O)c1ccc2nc(-c3ccccc3)c(Br)nc2c1.c1ccc(N2CCNCC2)cc1>>COC(=O)c1ccc2nc(-c3ccccc3)c(N3CCN(c4ccccc4)CC3)nc2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20090326009A1,CC1=CC(C)(C)Nc2ccc(-c3ccccc3O)c(C(=O)N3CCCC3)c21.CI>>COc1ccccc1-c1ccc2c(c1C(=O)N1CCCC1)C(C)=CC(C)(C)N2,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US06326359B1,COC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(COC4CCN(C)CC4)nc32)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C>>COC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(COC4CCN(C)CC4)nc32)[C@H](O)[C@@H]1O,,C1CCOC1,,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20100022585A1,CC(C)(C)OC(=O)NC(CCC(=O)Nc1ccc2cnccc2c1)c1ccsc1.Cl.ClCCl>>Cl.Cl.NC(CCC(=O)Nc1ccc2cnccc2c1)c1ccsc1,,ClCCl,,,,val
US20090048258A1,Nc1nc(-c2ccccc2)c(Cc2ccccc2)s1.O=C(O)CCC(=O)c1ccc2c(c1)OCCCO2>>O=C(CCC(=O)c1ccc2c(c1)OCCCO2)Nc1nc(-c2ccccc2)c(Cc2ccccc2)s1,,CC#N,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20020115674A1,Cc1ccc(-n2c(=O)n(OCc3ccccc3)c(=O)c3cc(F)c(N4CCCC4)nc32)cc1>>Cc1ccc(-n2c(=O)n(O)c(=O)c3cc(F)c(N4CCCC4)nc32)cc1,[Pd],C1CCOC1,,,,val
US04775675,CC(=O)N[C@@H](C(=O)O)C(C)(C)S.O=Cc1ccc(F)cc1>>CC(=O)N1[C@@H](c2ccc(F)cc2)SC(C)(C)[C@@H]1C(=O)O,,CCOCC,,Cl,,val
US05556863,CCC(=O)c1cnc2c(OCCSC)cccc2c1Cl.CCc1ccccc1N>>CCC(=O)c1cnc2c(OCCSC)cccc2c1Nc1ccccc1CC,,CC#N,,,,val
US20140350019A1,CC(C)OC(=O)CBr.COc1cc(CNc2c(C)ccc(O)c2C)cc(-c2cccc(F)c2)c1>>COc1cc(CNc2c(C)ccc(OCC(=O)OC(C)C)c2C)cc(-c2cccc(F)c2)c1,,CCC(C)=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110092529A1,OCC1=CCN(Cc2ccccc2)CC1.Oc1ccccc1Br>>Brc1ccccc1OCC1=CCN(Cc2ccccc2)CC1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04469868,CCC(N)CO.Cc1nc(Cl)c2c(n1)c(C)nn2C>>CCC(CO)Nc1nc(C)nc2c(C)nn(C)c12,,Cc1ccccc1,,[NH4+].[OH-],,val
US04352748,CC(C)C(=O)Cl.CCc1ccccc1>>CCc1ccc(C(=O)C(C)C)cc1,,C[N+](=O)[O-],,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04200641,C=C(C)n1c(=O)[nH]c2ccccc21.ClCCCCCCCl>>C=C(C)n1c(=O)n(CCCCCCCl)c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US04220646,Cc1ccc(N)nc1.O=C1OC(=O)c2nccnc21>>Cc1ccc(N2C(=O)c3nccnc3C2=O)nc1,,CC(=O)OC(C)=O,,CC(C)OC(C)C,,val
US20120101136A1,CCOC(=O)CCCCOc1ccc(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)c(OC)c1>>COc1cc(OCCCCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1,,CC(C)O,O,[Na+].[OH-],,val
US20160264578A1,COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc([N+](=O)[O-])cc4)cn3n(Cc3c(F)cccc3F)c2=O)nn1>>COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(N)cc4)cn3n(Cc3c(F)cccc3F)c2=O)nn1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20020177596A1,O=C(O)C1CN(C(=O)OCc2ccccc2)CCN1c1ccc(Cl)cc1[N+](=O)[O-]>>O=C1Nc2ccc(Cl)cc2N2CCN(C(=O)OCc3ccccc3)CC12,[Fe],CC(=O)O,,Cl,,val
US20050197370A1,FS(F)(F)(F)(F)c1ccc(C=Cc2nc(CCl)co2)cc1.O=S(CCn1ccnn1)Cc1ccc(O)cc1>>O=S(CCn1ccnn1)Cc1ccc(OCc2coc(/C=C/c3ccc(S(F)(F)(F)(F)F)cc3)n2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US06984743B1,COCCOC.Cl[Ti](Cl)(Cl)Cl>>COCCOC.Cl[Ti](Cl)(Cl)Cl,,ClCCl,,,,val
US06008220,O=C(O)CCC(=O)c1ccc(F)cc1.c1ccc(C2CCNCC2)cc1>>O=C(O)CCC(=O)c1ccc(N2CCC(c3ccccc3)CC2)cc1,,CS(C)=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US04680287,CCCCCCCCCCCCN.O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>CCCCCCCCCCCCN[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O,,CCO,,,,val
US20120190665A1,COc1ccc(Cl)cc1-c1c(NC(=O)OC(C)(C)C)cnn1C>>COc1ccc(Cl)cc1-c1c(N)cnn1C,,C1COCCO1,,Cl,,val
US06313310B1,CN(C)C=O.COc1ccsc1>>COc1ccsc1C=O,,CCOCC,,Cl,[Li]CCCC,val
US20060217362A1,O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1cccc2cccnc12)OCc1ccccc1>>O=C(O)C[C@@H]1C(=O)NCCN1S(=O)(=O)c1cccc2c1NCCC2,[Pd],CCOC(C)=O,,,,val
USH0000951,O=S(=O)([O-])[O-].O=[N+]([O-])[O-].[K+].[NH4+].[NH4+]>>O=S(=O)([O-])[O-].O=[N+]([O-])[O-].[K+].[NH4+].[NH4+],,O,,,,val
US04130716,CC(C)=O.COC(=O)c1cc2n(n1)-c1ccc(Cl)cc1C(c1ccccc1)=NC2.Cl>>Cl.O.O=C(O)c1cc2n(n1)-c1ccc(Cl)cc1C(c1ccccc1)=NC2,,CC(C)=O,,,,val
US20120232051A1,CC[Zn]CC.Cc1ccccc1-c1cc(Cl)ncc1N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CCc1cc(-c2ccccc2C)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1,,C1CCOC1,,,,val
US20110263589A1,COc1ccccc1-c1ccc2c(c1CCl)C(C)=CC(C)(C)N2.Oc1ccccc1>>COc1ccccc1-c1ccc2c(c1COc1ccccc1)C(C)=CC(C)(C)N2,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20090005420A1,COC(=O)Cc1ccc(Oc2ccc(S(=O)(=O)CC(C)C3CO3)cc2)cc1.NC(N)=S>>COC(=O)Cc1ccc(Oc2ccc(S(=O)(=O)CC(C)C3CS3)cc2)cc1,,CO,ClCCl,,,val
US20090264441A1,CCOC(=O)c1nc(-c2cc(Br)c(O)c(Br)c2)no1.COc1ccc(CCl)cc1>>CCOC(=O)c1nc(-c2cc(Br)c(OCc3ccc(OC)cc3)c(Br)c2)no1,,CN(C)C=O,,O,[H-].[Na+],val
US05712267,C[C@H]1C(S[C@H]2C[C@@H](C(=O)N3CCN(C(=O)OCc4ccc([N+](=O)[O-])cc4)[C@@H](C)C3)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)N2C(=O)[C@H]([C@@H](C)O)[C@@H]12.Cl>>C[C@H]1CN(C(=O)[C@@H]2C[C@H](SC3=C(C(=O)O)N4C(=O)[C@H]([C@@H](C)O)[C@H]4[C@H]3C)CN2)CCN1.Cl,,C1CCOC1,O,,,val
US20020028760A1,C[C@H](CCl)N1C(=O)CC2(CCCC2)CC1=O.Fc1cc(F)c(N2CCNCC2)cc1F>>C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O,,CO,,,,val
US04144234,COC(=O)[C@@H](N)CS.CO[C@H]1C=CO[C@@]2(C)Oc3c(C)c(O)c4c(c3C2=O)C(=O)C=C(NC(=O)C(C)=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C4=O>>COC1C=COC2(C)Oc3c(C)c(O)c4c(O)c(c5scnc5c4c3C2=O)NC(=O)C(C)=CC=CC(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C,,CO,,CCN(CC)CC,Cl,val
US20120123163A1,Cc1ccc(CN)cc1.FC(F)CCl>>Cc1ccc(CNCC(F)F)cc1,,O,,,,val
US05576335,COc1ccc(N)c([N+](=O)[O-])c1.O=C(Cl)Oc1ccccc1>>COc1ccc(NC(=O)Oc2ccccc2)c([N+](=O)[O-])c1,,ClCCl,,CC(C)NC(C)C,,val
US20080146567A1,NCc1cccc2nc(N[C@@H]3CCc4ccccc43)ccc12.O=Cc1ccc(F)cc1>>Fc1ccc(CNCc2cccc3nc(N[C@@H]4CCc5ccccc54)ccc23)cc1,,CC(Cl)Cl,,CC(=O)O,,val
US20140200344A1,O=C1c2ccccc2C(=O)N1C[C@@H]1C[C@H]1c1ccc(F)cc1>>NC[C@@H]1C[C@H]1c1ccc(F)cc1,,CCO,,NN,O,val
US20090281060A1,CC(C)COC(=O)Cl.c1cc(-c2noc(C3CCNCC3)n2)ccn1>>CC(C)COC(=O)N1CCC(c2nc(-c3ccncc3)no2)CC1,,ClCCl,,c1ccncc1,,val
US20140088101A1,CCCN.N#Cc1nc(C(=O)NCCCC(=O)O)c(O)c2ccn(Cc3ccccc3)c(=O)c12>>CCCNC(=O)CCCNC(=O)c1nc(C#N)c2c(=O)n(Cc3ccccc3)ccc2c1O,,ClCCl,,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20100113528A1,CCOc1ccc(C(=O)OC)cc1Cl>>CCOc1ccc(C(=O)O)cc1Cl,,CO,,[Na+].[OH-],,val
US05019575,CC(=O)Nc1ccc(C=CC(=O)CCl)cc1.COC(=S)NN>>CC(=O)Nc1ccc(C=CC2CSC(=O)NN2)cc1,,Cc1ccccc1,,,,val
US20050288290A1,CCOC(=O)c1cn2ncnc(O)c2c1C>>Cc1c(C(=O)O)cn2ncnc(O)c12,,C1CCOC1,,Cl,[Na+].[OH-],val
US06034086,O=C(O)c1cn(C2CC2)c2c(C(F)(F)F)c(F)c(F)cc2c1=O.c1cnc(N2CCNCC2)nc1>>O=C(O)c1cn(C2CC2)c2c(C(F)(F)F)c(N3CCN(c4ncccn4)CC3)c(F)cc2c1=O,,c1ccncc1,,,,val
US20040006071A1,CC#N.O=C(O)c1ccc(B(O)O)cc1.Oc1cccc(Br)c1>>COC(=O)c1ccc(-c2cccc(O)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US04474797,Cn1nc(Cl)c(Cl)c1S(=O)(=O)CCCl>>C=CS(=O)(=O)c1c(Cl)c(Cl)nn1C,,COCCOC,,CCN(CC)CC,,val
US05665730,COC(=O)Nc1cccc(C)c1CCl.Cc1nc2c(N)cccn2c1C>>COC(=O)Nc1cccc(C)c1CNc1cccn2c(C)c(C)nc12,,CC(C)=O,O,[I-].[Na+],,val
US20140309193A1,COc1ccc(-n2c(C(=O)N(C)C)c(OCc3ccccc3)c(OCc3ccccc3)c2P(C)(C)=O)cc1>>COc1ccc(-n2c(C(=O)N(C)C)c(O)c(O)c2P(C)(C)=O)cc1,[Pd],CO,,,,val
US20050256107A1,CC1CCC(C)N1c1ccc(NC(=O)C(C)(C)N)cc1.O=C(O)c1ccc(Br)s1>>CC1CCC(C)N1c1ccc(NC(=O)C(C)(C)NC(=O)c2ccc(Br)s2)cc1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US05885986,CCCN(CCC)Cc1cnc(-c2ncn3c2CN(C)C(=O)c2cc(F)ccc2-3)o1.Cl>>CCCN(CCC)Cc1cnc(-c2ncn3c2CN(C)C(=O)c2cc(F)ccc2-3)o1.Cl,,CCOC(C)=O,,,,val
US20040157883A1,COc1ccc(/C=N/NC(=N)N)cc1.O=C(c1ccccc1)C(Br)c1ccccc1>>COc1ccc(/C=N/n2c(N)nc(-c3ccccc3)c2-c2ccccc2)cc1,,CCO,,,,val
US20100093726A1,Nc1ccnc2cc(Cl)ccc12.OC(c1ccc(Cl)cc1)c1ccc(CN2CCOCC2)cc1>>NC1=CCN(C(c2ccc(Cl)cc2)c2ccc(CN3CCOCC3)cc2)c2cc(Cl)ccc21,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20010027197A1,CC(C)(C)OC(=O)Nc1ccncc1C(=O)O>>Nc1ccncc1C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140206663A1,CCOC(=O)C(C)N1C(=S)COc2cc(C)c(Br)cc21.NN>>Cc1cc2c(cc1Br)N1C(=NNC(=O)C1C)CO2,,CCO,,O,,val
US20050107435A1,Cc1cn(C[C@H]2CN(c3ccc(-c4ccc(C5=NOC(CO[Si](C)(C)C(C)(C)C)C5)cc4)cc3)C(=O)O2)nn1>>Cc1cn(C[C@H]2CN(c3ccc(-c4ccc(C5=NOC(CO)C5)cc4)cc3)C(=O)O2)nn1,,C1CCOC1,CCOC(C)=O,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20160122344A1,CCOCCOc1cc2c(cc1OC)-c1cc(=O)c(C(=O)OCC)cn1C(C(C)(C)COC)C2>>CCOCCOc1cc2c(cc1OC)-c1cc(=O)c(C(=O)O)cn1C(C(C)(C)COC)C2,,C1CCOC1,CCO,Cl,[Li+].[OH-],val
US20070232627A1,CC(C)(N)COP(=O)(OC(C)(C)C)OC(C)(C)C.COC(=O)Nc1ccc(Sc2ccc(C(=O)O)cc2Nc2ncnc3nc(C(C)C)ccc23)cc1>>COC(=O)Nc1ccc(Sc2ccc(C(=O)NC(C)(C)COP(=O)(OC(C)(C)C)OC(C)(C)C)cc2Nc2ncnc3nc(C(C)C)ccc23)cc1,,CS(C)=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US05424308,CCOC(=O)c1nn(-c2ccccc2)c2c1Cc1ccccc1-2>>O=C(O)c1nn(-c2ccccc2)c2c1Cc1ccccc1-2,,CCO,,Cl,[K+].[OH-],val
US20130237502A1,CS(=O)(=O)NCc1ccc(-c2ccc([C@@H](O)[C@@H](CF)NC(=O)C(F)F)cc2)cn1.O=C(Cl)CCCBr>>CS(=O)(=O)NCc1ccc(-c2ccc([C@@H](OC(=O)CCCBr)[C@@H](CF)NC(=O)C(F)F)cc2)cn1,CN(C)c1ccncc1,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20060122197A1,O=C(OCc1ccccc1)N1CCC[C@H](NC(=O)C23CC4CC(C2)C(O)C(C4)C3)C1>>O=C(N[C@H]1CCCNC1)C12CC3CC(C1)C(O)C(C3)C2,[Pd],CO,,,,val
US05468743,Cc1ccc(CCOS(C)(=O)=O)cc1.c1c[nH]cn1>>Cc1ccc(CCn2ccnc2)cc1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20130137680A1,O=C(O)c1ccc([N+](=O)[O-])c(F)c1.OCc1ccccc1>>O=C(OCc1ccccc1)c1ccc([N+](=O)[O-])c(F)c1,,ClCCl,c1ccncc1,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US05138069,CCCCc1nc(Cl)c(CO)n1Cc1ccc(OCc2ccccc2)cc1>>CCCCc1nc(Cl)c(CO)n1Cc1ccc(O)cc1,[Pd],C1CCOC1,,,,val
US20040259907A1,Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(C#CCO)oc21>>Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCCO)oc21,[Pd],CCO,,,,val
US20140336383A1,CC(C)CNC(=O)NCC(C)C.O=C(Cl)CC(=O)Cl>>CC(C)CN1C(=O)CC(=O)N(CC(C)C)C1=O,,ClCCl,,,,val
US20100029650A1,CS(=O)(=O)c1ccc(-c2ccc(OCC3CCNCC3)cn2)cc1.N#CBr>>CS(=O)(=O)c1ccc(-c2ccc(OCC3CCN(C#N)CC3)cn2)cc1,,CO,ClCCl,CC(=O)[O-].[Na+],,val
US20110070317A1,CC(C)(C)OC(=O)N1CCOC(C(=O)Nc2c[nH]c3ncc(Br)c(F)c23)C1.CC(C)(C)OC(=O)N[C@@H]1CCCNC1>>CC(C)(C)OC(=O)N[C@@H]1CCCN(c2c(Br)cnc3[nH]cc(NC(=O)C4CN(C(=O)OC(C)(C)C)CCO4)c23)C1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20080188528A1,BrC1c2ccccc2-c2ccccc21.COC(=O)c1ccc[nH]c1=O>>COC(=O)c1cccn(C2c3ccccc3-c3ccccc32)c1=O,,CN(C)C=O,,Cl,[H-].[Na+],val
US04668697,CC(=O)Cl.NS(=O)(=O)c1cc2cc(O)ccc2s1>>CC(=O)Oc1ccc2sc(S(N)(=O)=O)cc2c1,,CC(C)=O,,CCN(CC)CC,,val
US20100029637A1,Br.CCOC(=O)Cn1ccccc1=N>>Br.O=C1CN2C=CC=CC2=N1,,CCO,,,,val
US20070249649A1,O=[N+]([O-])c1ccc(CBr)cc1.OCCN1CCNCC1>>Br.O=[N+]([O-])c1ccc(CN2CCN(CCO)CC2)cc1,,CCO,,,,val
US20030105081A1,COc1ccc([N+](=O)[O-])cn1.Cc1ccc(S(=O)(=O)CCl)cc1>>COc1ccc([N+](=O)[O-])c(CS(=O)(=O)c2ccc(C)cc2)n1,,C1CCOC1,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US20140066427A1,COC(=O)C1CN(Cc2ccc(-c3ccc(S(=O)(=O)N(C)c4cccc(OC)c4)cc3)cc2)C1>>COc1cccc(N(C)S(=O)(=O)c2ccc(-c3ccc(CN4CC(C(=O)O)C4)cc3)cc2)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20130274274A1,CSc1nc(Nc2ccc(Oc3cccc(F)c3)cc2)c2c(=O)[nH]ccc2n1.O=C1CCC(=O)N1Br>>CSc1nc(Nc2ccc(Oc3cccc(F)c3)cc2)c2c(=O)[nH]cc(Br)c2n1,,CN(C)C=O,,,,val
US20010007867A1,CCC(CC)Nc1c(Br)c(C)nc2c1nnn2-c1c(C)cc(C)cc1C.CI>>CCC(CC)N(C)c1c(Br)c(C)nc2c1nnn2-c1c(C)cc(C)cc1C,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20120142705A1,COC(=O)C(CC1CCCC1)N1C(=O)C(=O)c2cc(Cl)ccc21>>O=C1C(=O)N(C(CC2CCCC2)C(=O)O)c2ccc(Cl)cc21,,C1CCOC1,O,[Li+].[OH-],,val
US20120252810A1,CC(C)(C)OC(=O)NCCOCCN.O=C(O)C/C=C/c1cccnc1>>CC(C)(C)OC(=O)NCCOCCNC(=O)C/C=C/c1cccnc1,,CC#N,CCOC(C)=O,CCN=C=NCCCN(C)C,,val
US20130096125A1,O=Cc1ccc(B(O)O)o1.O=[N+]([O-])c1cccc(Br)c1>>O=Cc1ccc(-c2cccc([N+](=O)[O-])c2)o1,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20130338134A1,CC1(C)OB(C2=CCOCC2)OC1(C)C.COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(Br)cc4c3N(C)C2=O)c1F>>COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(C5=CCOCC5)cc4c3N(C)C2=O)c1F,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20160000760A1,CSC(NC#N)Nc1cc(Cl)c(-c2ccc(S(=O)(=O)N3CCN(C)CC3)cc2)c(C(F)(F)F)c1.NN>>CN1CCN(S(=O)(=O)c2ccc(-c3c(Cl)cc(Nc4n[nH]c(N)n4)cc3C(F)(F)F)cc2)CC1,,CCO,,,,val
US20140315888A1,CN(C(=O)OC(C)(C)C)C1CNC1.FC(F)(F)c1cnc2nc(Cl)c(Cl)nc2c1>>CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc(C(F)(F)F)cc3nc2Cl)C1,,ClCCl,,Cl,[Cl-].[NH4+],val
US03997553,COC(=O)NC#N.Nc1ccccc1N>>COC(=O)Nc1nc2ccccc2[nH]1,,O,,CC(=O)O,,val
US04826854,CCOC(=O)C(=CN)C(=O)OCC.O=C1CCCCCCCCC1>>CCOC(=O)C(=CNC1=CCCCCCCCC1)C(=O)OCC,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US05763451,CC(C)(C)[Si](C)(C)Cl.COC1(OC)C[C@H](C)c2cnc3ccc(O)cc3c2[C@H]1O>>COC1(OC)C[C@H](C)c2cnc3ccc(O[Si](C)(C)C(C)(C)C)cc3c2[C@H]1O,,CN(C)C=O,,c1c[nH]cn1,,val
US04038405,FC(F)(F)c1nncn1-c1ccccc1.O=[N+]([O-])O>>O=[N+]([O-])c1cccc(-n2cnnc2C(F)(F)F)c1,,O=S(=O)(O)O,,,,val
US20140235620A1,CC(C)[C@H]1COC(=O)N1c1ccnc(Cl)n1.C[C@H](N)c1ccc(Oc2ccc(F)cc2)nc1>>CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Oc3ccc(F)cc3)nc2)n1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20120220577A1,COc1ccc(CCl)cc1.O=C(O)c1cc(O)c2c(Cl)cc(Cl)cc2c1>>COc1ccc(COC(=O)c2cc(O)c3c(Cl)cc(Cl)cc3c2)cc1,,CN1CCCC1=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20050256159A1,O=C(c1ccc(F)cc1)C1CCNCC1.O=S(=O)(Cl)c1cccc(Cl)c1>>O=C(c1ccc(F)cc1)C1CCN(S(=O)(=O)c2cccc(Cl)c2)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US05041445,ICCCCCI.O=C1CSCN1CCCCBr>>O=C1N(CCCCBr)CSC12CCCCC2,,C1CCOC1,,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20150158855A1,CC(C)(C)OC(=O)N[C@@H](CO)Cc1cccc(I)c1>>CC(C)(C)OC(=O)N[C@@H](C=O)Cc1cccc(I)c1,,ClCCl,,,,val
US20090258877A1,COC(=O)c1nc[nH]n1.O=C(CCl)c1ccc(F)cc1F>>COC(=O)c1ncnn1CC(=O)c1ccc(F)cc1F,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05051437,CS(=O)(=O)O.Nc1ccccc1O.O=C(O)c1ccc(O)cc1>>Oc1ccc(-c2nc3ccccc3s2)cc1,,O=C([O-])O,[Na+],O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US05134128,CC(=O)OC(C)=O.C[Si](C)(C)c1cc(C(O)CCCCCCCCc2cccs2)co1>>CC(=O)OC(CCCCCCCCc1cccs1)c1coc([Si](C)(C)C)c1,,CCCCCC,CCOCC,c1ccncc1,,val
US20040110754A1,CON(C)C(=O)C=Cc1ccccc1Cl.C[S+](C)(C)=O>>CON(C)C(=O)C1CC1c1ccccc1Cl,,CN(C)C=O,,[H-].[Na+],,val
US20110257174A1,COC(=O)c1cccc(CN2CCCC2)n1>>O=C(O)c1cccc(CN2CCCC2)n1,,CCO,O,Cl,[Na+].[OH-],val
US20030236438A1,O=CC[C@H](COC(=O)c1ccccc1)c1ccc(N2CCCC2)cc1>>C[C@H](CC=O)c1ccc(N2CCCC2)cc1,,ClC(Cl)Cl,,,,val
US20090312370A1,C=CCCCBr.COC(=O)c1cc(NC(=O)OCc2ccccc2)cc(-c2ncco2)c1>>C=CCCCN(C(=O)OCc1ccccc1)c1cc(C(=O)OC)cc(-c2ncco2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090176821A1,CC(C)(C)C(=O)OC(=O)C(C)(C)C.CCc1nc2c(N)nc3ccccc3c2n1CCCCNS(C)(=O)=O>>CCc1nc2c(NC(=O)C(C)(C)C)nc3ccccc3c2n1CCCCNS(C)(=O)=O,,CCOCC,,CN1CCCC1=O,,val
US20100048564A1,CC(C)(C)OC(=O)NCc1cc(Cl)ccc1[N+](=O)[O-].Oc1ccccc1F>>CC(C)(C)OC(=O)NCc1cc(Oc2ccccc2F)ccc1[N+](=O)[O-],,CN(C)C=O,,[H-].[Na+],,val
US20110195954A1,COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)O)ncn3)CC1)C(=O)N2.COc1ccc2c(c1)NCC2>>COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)N4CCc5ccc(OC)cc54)ncn3)CC1)C(=O)N2,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20030225097A1,CC(C)C(=O)Cl.Nc1ccc2c(c1)-c1ccccc1S2(=O)=O>>CC(C)C(=O)Nc1ccc2c(c1)-c1ccccc1S2(=O)=O,,ClCCl,,CCN(CC)CC,,val
US06812229B1,CC(C)(C)ON=O.COC(=O)NCc1cc(CC#N)ccc1Cl>>COC(=O)NCc1cc(C(C#N)=NO)ccc1Cl,,CCOC(C)=O,O,CCO,[Na+].[OH-],val
US20040097485A1,N#CC(=CC(=O)Cl)c1cccs1.[N-]=[N+]=[N-]>>N#CC(=CC(=O)N=[N+]=[N-])c1cccs1,,C1COCCO1,,O,,val
US20100041646A1,CC(C)(C)[Si](C)(C)OCCNc1ccc(N2C[C@H](CNC(=O)c3ccc(Cl)s3)OC2=O)cc1.N#CBr>>CC(C)(C)[Si](C)(C)OCCN(C#N)c1ccc(N2C[C@H](CNC(=O)c3ccc(Cl)s3)OC2=O)cc1,,C1CCOC1,ClCCl,O,O=C([O-])O.[Na+],val
US20130317065A1,COc1ccc(CC(=O)C(C)C)c(NC(=O)OC(C)(C)C)c1.N#Cc1cccc(CCl)n1>>COc1ccc(C(Cc2cccc(C#N)n2)C(=O)C(C)C)c(NC(=O)OC(C)(C)C)c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20020183361A1,CC(C)(C)OC(=O)N1CCC([C@@H](CO)NC(=O)OCC2c3ccccc3-c3ccccc32)CC1>>CC(C)(C)OC(=O)N1CCC([C@H](N)CO)CC1,,CN(C)C=O,,C1CCNCC1,,val
US20080166359A1,CC(C)c1cc(C(C)C)c(S(=O)(=O)Cl)c(C(C)C)c1.CC(O)C1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1>>CC(C)c1cc(C(C)C)c(S(=O)(=O)OC(C)C2(O)CN(C(=O)c3ccc(F)c(F)c3Nc3ccc(I)cc3F)C2)c(C(C)C)c1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20030078251A1,COC(=O)c1ccoc1CCNC(=O)C[C@H]1O[C@H](c2cccc(OC)c2OC)c2cc(Cl)ccc2N(CC(C)(C)CO)C1=O>>COc1cccc([C@H]2O[C@H](CC(=O)NCCc3occc3C(=O)O)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,CO,,[Na+].[OH-],,val
US20160106754A1,CC(=O)NN1C(=O)CC(=O)CC12CCOCC2.Nc1cc(Cl)c(OC(F)(F)F)cc1SSc1cc(OC(F)(F)F)c(Cl)cc1N>>CC(=O)NN1C(=O)C2=C(CC13CCOCC3)Nc1cc(Cl)c(OC(F)(F)F)cc1S2,CCN(CC)CC,CCO,,,,val
US05463073,CCSc1nc2c(C(=O)OC)sc(C)c2[nH]1.N#Cc1ccccc1-c1ccc(CBr)cc1>>CCSc1nc2c(C)sc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2C#N)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US04999356,Fc1ccccc1C(=NNc1ccccc1)N1CCN(c2ccccc2)CC1>>c1ccc(N2CCN(c3nn(-c4ccccc4)c4ccccc34)CC2)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20110046169A1,Cn1cc(C(=O)O)c(=O)n1-c1ccccc1Cl.Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1>>Cn1cc(C(=O)Nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c(F)c2)c(=O)n1-c1ccccc1Cl,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120225061A1,BrBr.COC(=O)c1ccc(F)c(-c2c(F)cc(CO)cc2F)n1>>COC(=O)c1ccc(F)c(-c2c(F)cc(CBr)cc2F)n1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20020147334A1,COC(=O)CC(Cc1ccc(OC)cc1)C(=O)O.COC(CN)OC>>COC(=O)CC(Cc1ccc(OC)cc1)C(=O)NCC(OC)OC,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20070093479A1,CCCCNc1nn(COCC[Si](C)(C)C)c2cc(Cl)c(-c3ccccc3)cc12>>CCCCNc1n[nH]c2cc(Cl)c(-c3ccccc3)cc12,,CO,,Cl,,val
US20150191478A1,C#Cc1cncc(N)c1.Oc1c(I)cncc1I>>Nc1cncc(-c2cc3cncc(I)c3o2)c1,O=[Cu],CCOC(C)=O,c1ccncc1,,,val
US20090247567A1,CC(C)(C)OC(=O)NCc1ccc(-c2cc3c(s2)-c2ncccc2OCC3)cc1>>NCc1ccc(-c2cc3c(s2)-c2ncccc2OCC3)cc1,,C1COCCO1,ClCCl,Cl,,val
US20030149029A1,CCOC(=O)CCc1ccc(S(=O)(=O)CCc2c(CCO)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1.CS(=O)(=O)Cl>>CCOC(=O)CCc1ccc(S(=O)(=O)CCc2c(CCOS(C)(=O)=O)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1,,ClCCl,,CCN(CC)CC,O,val
US06022718,CCCCCCCCCCCCCC(=O)O.COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O>>CCCCCCCCCCCCCC(=O)NCc1ccc(O)c(OC)c1,,CCCCCC,,,,val
US05521188,CC#N.CCO.N#Cc1ccc2[nH]cc(CCCO)c2c1>>NCc1ccc2[nH]cc(CCCO)c2c1.[NH4+].[OH-],[Pd],CCO,,CO,,val
US20080027083A1,CCOC(=O)[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)OCc2ccccc2)C1=O>>CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)OCc3ccccc3)C2=O)[C@H](C(=O)O)C1,,Cl,,,,val
US20030216570A1,CC(=O)Cl.CC1(C)COc2ccc(Br)cc21>>CC(=O)c1cc(Br)cc2c1OCC2(C)C,,ClCCl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20150025087A1,CCOC(=O)c1ncnc(Cl)c1C.CNC>>CCOC(=O)c1ncnc(N(C)C)c1C,,C1COCCO1,O,C1CCOC1,CCN(C(C)C)C(C)C,val
US06642264B1,CCOC(=O)c1sc2nc3ccccc3n2c1C>>Cc1c(CO)sc2nc3ccccc3n12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070066617A1,COC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1C.NO>>Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)NO,,CO,,Cl,[K+].[OH-],val
US20060100229A1,CCCCn1nc(C#N)c(-c2ccccc2NC(=O)C(C)(C)C)c1CC>>CCCCn1nc2c(N)nc3ccccc3c2c1CC,,CCO,,C,C[O-].[Na+],val
US06156801,CO.O=[N+]([O-])c1cc(CCl)ccc1Oc1ccc(OCc2ccccc2)cc1>>COCc1cccc([N+](=O)[O-])c1,,O,,[H-].[Na+],,val
US20160185764A1,C[C@H]1[C@H](CO)[C@@H]2[C@@H](C)OC(=O)[C@@H]2CC1(F)F>>C[C@H]1[C@H](C=O)[C@@H]2[C@@H](C)OC(=O)[C@@H]2CC1(F)F,,ClCCl,,,,val
US06479519B1,CCOC(=O)CCc1ccc(N)cn1.COc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1C>>CCOC(=O)CCc1ccc(NC(=O)Cc2ccc(NC(=O)Nc3ccccc3C)c(OC)c2)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150232435A1,C1CN(C2CC2)CCN1.CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCN(C4CC4)CC3)CC2)cc(C(F)(F)F)n1,,CO,ClC(Cl)Cl,,,val
US20100136136A1,CN1CCN(CCCOc2ccc(N)c([N+](=O)[O-])c2)CC1>>CN1CCN(CCCOc2ccc(N)c(N)c2)CC1,[Pd],CCO,,,,val
US20100168194A1,CN(C)S(F)(F)F.O=C(C(=O)c1ccc(F)c(C#CCCO)c1)c1ccc(OC(F)F)cc1>>O=C(C(=O)c1ccc(F)c(C#CCCF)c1)c1ccc(OC(F)F)cc1,,ClCCl,,[Cl-].[Na+],,val
US20090018132A1,CC(OCC1(c2ccc(F)cc2)CCN(C(=O)OC(C)(C)C)CC1)c1cc(F)cc2cn(COCC[Si](C)(C)C)nc12>>CC(OCC1(c2ccc(F)cc2)CCNCC1)c1cc(F)cc2c[nH]nc12,,O=C(O)C(F)(F)F,,,,val
US06362177B1,Nc1ccc(OC(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCNC1.O=[N+]([O-])c1cc(Cl)ccc1CCl>>Nc1cc(Cl)ccc1CN1CC[C@@H](NC(=O)CNC(=O)c2cc(OC(F)(F)F)ccc2N)C1,,ClC(Cl)Cl,,CC#N,,val
US20090042897A1,CCOC(=O)C1CCC(O)(CNc2ccccc2)CC1.O=C(Cl)Oc1ccccc1>>CCOC(=O)C1CCC(O)(CN(C(=O)Oc2ccccc2)c2ccccc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,[Cl-].[NH4+],val
US20040110945A1,CCOC(=O)Cc1ccc(NC(=O)c2nccc3ccccc23)c(Br)c1>>O=C(O)Cc1ccc(NC(=O)c2nccc3ccccc23)c(Br)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20080097108A1,CCCCNCCCC.COc1ccc2c3c(n(CC(=O)O)c2c1)CCCC3>>CCCCN(CCCC)C(=O)Cn1c2c(c3ccc(OC)cc31)CCCC2,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US04578380,CN(C)CCCS.Clc1nc(-c2ccccc2)nc2c1Cc1ccccc1O2>>CN(C)CCCSc1nc(-c2ccccc2)nc2c1Cc1ccccc1O2,,CCO,,[Na],,val
US20090221645A1,O=C(CBr)c1ccc2ccccc2c1.S=C1NCCN1>>Br.C1=C(c2ccc3ccccc3c2)N2CCN=C2S1,,CCO,,CC(=O)O,,val
US20120184542A1,CCOC(=O)c1cnc(N2CCN(C)CC2)nc1N>>CN1CCN(c2ncc(CO)c(N)n2)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120035195A1,CC[C@H]1C(=O)N(C)C(NC(=O)OC(C)(C)C)=N[C@]1(C)c1cccc([N+](=O)[O-])c1>>CC[C@H]1C(=O)N(C)C(NC(=O)OC(C)(C)C)=N[C@]1(C)c1cccc(N)c1,[Pd],CCO,,CCN(CC)CC,,val
US20100298290A1,COC(=O)C1CC(C)(C)CCC1=O.N=C(N)CCl>>CC1(C)CCc2nc(CCl)nc(O)c2C1,,CO,,Cl,C[O-].[Na+],val
US20160229794A1,CCCC(=O)Cl.Nc1ccc(N=Nc2ccc(N)cc2)cc1>>CCCC(=O)Nc1ccc(N=Nc2ccc(N)cc2)cc1,,CCOC(C)=O,,,,val
US20110207704A1,CC(C)Oc1ncc(C(N)=O)cc1Cl>>CC(C)Oc1ncc(C#N)cc1Cl,,ClCCCl,,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US20100292242A1,NC(=O)c1ccc(B(O)O)cc1.O=S(=O)(Oc1ccc2c(c1)CNCC2c1ccc(Cl)c(Cl)c1)C(F)(F)F>>NC(=O)c1ccc(-c2ccc3c(c2)CNCC3c2ccc(Cl)c(Cl)c2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150353570A1,N.O=C1CC[C@H]2CC[C@H](c3nc(Br)c4c(Cl)nccn34)CN12>>Nc1nccn2c([C@H]3CC[C@@H]4CCC(=O)N4C3)nc(Br)c12,,CC(C)O,,,,val
US20090181942A1,Nc1ccc(Cl)cc1C(O)c1cccc(F)c1F.O=C(O)CC(S)C(=O)O>>O=C(O)CC1SC(c2cccc(F)c2F)c2cc(Cl)ccc2NC1=O,,C1COCCO1,,Cl,,val
US20070179165A1,O=c1c(CCl)nn(Cc2ccccc2)c2cccc(Cl)c12>>Cc1nn(Cc2ccccc2)c2cccc(Cl)c2c1=O,,CS(C)=O,O,[BH4-].[Na+],,val
US20150291572A1,CON(C)C(=O)c1ncc(Br)cc1Cl>>O=Cc1ncc(Br)cc1Cl,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060229343A1,CC(=O)Cl.CON=C1C[C@@H](c2noc(CN3CCNCC3)n2)N(C(=O)c2ccc(-c3ccccc3)cc2)C1>>CON=C1C[C@@H](c2noc(CN3CCN(C(C)=O)CC3)n2)N(C(=O)c2ccc(-c3ccccc3)cc2)C1,,ClCCl,,CCN(CC)CC,O=C([O-])[O-].[Na+].[Na+],val
US20060223868A1,CC(C)(C)c1ccc(C(=O)Nc2ccc3sc(C(=O)O)nc3c2)cc1.CO>>COC(=O)c1nc2cc(NC(=O)c3ccc(C(C)(C)C)cc3)ccc2s1,Cl,,,,,val
US20160244451A1,CC(C)O.CS(=O)(=O)OCc1ncc(Br)cn1>>CC(C)OCc1ncc(Br)cn1,,O,,[H-].[Na+],,val
US20110160198A1,COC(=O)[C@H](Cc1ccc(-c2ccnc(C)c2C)cc1)NC(=O)[C@@H]1Cc2cc3c(cc2CN1)O[C@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)CO3.Cc1nc(C(=O)O)c(C)o1>>Cc1nc(C(=O)N2Cc3cc4c(cc3C[C@H]2C(=O)N[C@@H](Cc2ccc(-c3ccnc(C)c3C)cc2)C(=O)O)OC[C@@H](c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)O4)c(C)o1,,ClCCl,,ClCCCl,,val
US20100041891A1,CCOC(=O)c1cccc(-c2ccnc3cc(CO)oc23)c1.O=S(Cl)Cl>>CCOC(=O)c1cccc(-c2ccnc3cc(CCl)oc23)c1,,ClCCl,,,,val
US20090181956A1,O=C1CCC(=O)N1Br.O=Cc1cccn1-c1ncccc1Cl>>O=Cc1cc(Br)cn1-c1ncccc1Cl,,CN(C)C=O,,O,,val
US20130252941A1,CC(C)(C)OC(=O)Nc1ncc(Cl)c2nn(-c3c(Cl)cccc3Cl)cc12>>Nc1ncc(Cl)c2nn(-c3c(Cl)cccc3Cl)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100261733A1,Cc1cnc(NC(=O)[C@@H](O)CO[C@H](C)CO[Si](C(C)C)(C(C)C)C(C)C)cn1.N#Cc1cccc(Cl)c1-n1ncc2c(Cl)ncnc21>>Cc1cnc(NC(=O)[C@H](CO[C@H](C)CO[Si](C(C)C)(C(C)C)C(C)C)Oc2ncnc3c2cnn3-c2c(Cl)cccc2C#N)cn1,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20040248890A1,Cc1ccc2c(Cl)nc(-c3ccccc3O)nc2c1.NC1CCNCC1>>Cc1ccc2c(N3CCC(N)CC3)nc(-c3ccccc3O)nc2c1,,ClCCl,,CCN(CC)CC,,val
US20130209400A1,O=P(Cl)(Cl)Cl.Oc1ccnc(-c2cnn3ccncc23)n1>>Clc1ccnc(-c2cnn3ccncc23)n1,,CCOC(C)=O,,[Na+].[OH-],,val
US20040138195A1,COc1ccc2[nH]c(C(=O)N3CC(CCl)c4c3cc(OCc3ccccc3)c3ncccc43)cc2c1>>COc1ccc2[nH]c(C(=O)N3CC(CCl)c4c3cc(O)c3ncccc43)cc2c1,[Pd],O,,C1CCOC1,,val
US20130158009A1,Cc1cc(N[C@H]2CCN(C3CCN(C(=O)OCc4ccccc4)CC3)C2=O)c(F)cc1S(C)(=O)=O>>Cc1cc(N[C@H]2CCN(C3CCNCC3)C2=O)c(F)cc1S(C)(=O)=O,[Pd],CCO,,[H][H],,val
US20080287396A1,CC1(C)CC(=O)Oc2ccc(Br)cc21.CCO[PH](=O)CP(=O)(OCC)OCC>>CCOP(=O)(CP(=O)(OCC)c1ccc2c(c1)C(C)(C)CC(=O)O2)OCC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,,CCN(CC)CC,,val
US20080051399A1,CC(=O)OC1C[C@@H](C)c2c(Cl)ncnc21.C[C@H]1CN(C(=O)OC(C)(C)C)CCN1>>CC(=O)OC1C[C@@H](C)c2c1ncnc2N1CCN(C(=O)OC(C)(C)C)C[C@@H]1C,,CCOC(C)=O,CN1CCCC1=O,,,val
US20160096827A1,CC(C)(C)OC(=O)N1CCC(n2cc(Nc3ncnc(-c4ccc(O[C@H]5CCCC[C@H]5F)c(C#N)c4)n3)cn2)CC1>>N#Cc1cc(-c2ncnc(Nc3cnn(C4CCNCC4)c3)n2)ccc1O[C@H]1CCCC[C@H]1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020052495A1,CO.COC(=O)C1OC1(c1ccccc1)c1ccccc1>>COC(=O)C(O)C(OC)(c1ccccc1)c1ccccc1,,CO,,CCOCC,FB(F)F,val
US20120264735A1,CCOC(=O)Nc1cccc(Cc2nn(-c3cnn(CCN=[N+]=[N-])c3)ccc2=O)c1>>CCOC(=O)Nc1cccc(Cc2nn(-c3cnn(CCN)c3)ccc2=O)c1,[Pd],CCO,,,,val
US04988711,CC(C)C(=O)CC(C(=O)c1ccccc1)c1ccc(F)cc1.NN1CCCC1>>CC(C)c1cc(-c2ccc(F)cc2)c(-c2ccccc2)n1N1CCCC1,,Cc1ccccc1,,Cl,,val
US20150376181A1,C[Si](C)(C)C#Cc1cncnc1Nc1cc(Cl)c2n(c1=O)C1(CCCCC1)NC2=O>>C#Cc1cncnc1Nc1cc(Cl)c2n(c1=O)C1(CCCCC1)NC2=O,,CO,,O=C([O-])[O-].[K+].[K+],,val
US06140333,CC(C)(C)[C@H]1OC(=O)[C@](c2ccccc2)([C@@H]2CCC(F)(F)C2)O1>>O=C(O)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1,,CO,,[Na+].[OH-],,val
US20150148340A1,CCI.CCOC(=O)c1cn(-c2ccc3c(c2)[nH]c(=O)n3C)c(=O)n(Cc2cccc(Cl)c2C(F)(F)F)c1=O>>CCOC(=O)c1cn(-c2ccc3c(c2)n(CC)c(=O)n3C)c(=O)n(Cc2cccc(Cl)c2C(F)(F)F)c1=O,,CN(C)C=O,O,[I-].[K+],,val
US20090124618A1,C=O.C[C@H](c1ccccc1)N1CCO[C@@H](c2ccc(N[C@@H]3CCOC3)cc2)C1>>C[C@H](c1ccccc1)N1CCO[C@@H](c2ccc(N(C)[C@@H]3CCOC3)cc2)C1,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040077669A1,C#CCOc1cc(Cl)ncn1.Cc1ccc(O)cc1>>C#CCOc1cc(Oc2ccc(C)cc2)ncn1,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20110009400A1,CC(C)(C)C(=O)OCC(N)=S.O=[N+]([O-])c1cnc(Cl)c([N+](=O)[O-])c1>>CC(C)(C)C(=O)OCc1nc2cc([N+](=O)[O-])cnc2s1,,O=S1(=O)CCCC1,,CCOC(C)=O,,val
US20030216445A1,CCOC(=O)C(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)OC(C)(C)C)c2)S(=O)(=O)c2cccnc2)cc1>>CCOC(=O)C(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(=O)(=O)c2cccnc2)cc1,,CO,,[Na+].[OH-],,val
US20100286145A1,C=C(C)c1cc(CN=[N+]=[N-])c(C)nc1C>>C=C(C)c1cc(CN)c(C)nc1C,[Pd],CO,,,,val
US06562808B1,Cc1ccc(S(=O)(=O)OCCc2ccc(N(C)C)cc2)cc1.c1ccc2c(c1)COc1ccccc1N2C[C@H]1CCCN1>>CN(C)c1ccc(CCN2CCC[C@@H]2CN2c3ccccc3COc3ccccc32)cc1,,CC#N,,[I-].[Na+],,val
US04588719,O=C1c2ccccc2C(=O)N1CCCBr.Oc1cccc2c1CCCC2N1CCOCC1>>O=C1c2ccccc2C(=O)N1CCCOc1cccc2c1CCCC2N1CCOCC1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US06391948B1,FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CCI.NC(N)=S>>FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CCS,,CCO,,,,val
US06204264B1,CCCCCCCCCCCCCCCCCc1nc2cc(C(=O)NC)ccc2n1CCN(C)C.Cl>>CCCCCCCCCCCCCCCCCc1nc2cc(C(=O)NC)ccc2n1CCN(C)C.Cl,,CCO,CCOC(C)=O,,,val
US20090270363A1,NC(=S)c1ccc(C2OCCO2)cc1.O=C1CCCC2OC12>>O=Cc1ccc(-c2nc3c(s2)C(O)CCC3)cc1,,CCO,,,,val
US05026894,Nc1ccccc1-c1ccccc1.[I-]>>Ic1ccccc1-c1ccccc1,,Cl,O,O=N[O-].[Na+],,val
US20080161290A1,CCc1cc(OC)cc(NC(=O)OC)c1C(=O)OC>>CCc1cc(OC)cc(N)c1C(=O)O,,C1CCOC1,O,CO,[Li+].[OH-],val
US20100048631A1,CC(C)(C)OC(=O)N1CCC(CCCOc2ccc(CS(C)(=O)=O)c(F)c2)CC1>>CS(=O)(=O)Cc1ccc(OCCCC2CCNCC2)cc1F,,C1COCCO1,,Cl,,val
US20150266872A1,CCOC(=O)C(Cl)C(C)=O.Nc1ncc(C(F)(F)F)cc1Cl>>CCOC(=O)c1c(C)nc2c(Cl)cc(C(F)(F)F)cn12,,CC(C)O,,O=C([O-])O.[Na+],,val
US20140221343A1,CC(=O)OCCCBr.Nc1nccc2[nH]c(Sc3cc4c(cc3Br)OCO4)nc12>>CC(=O)OCCCn1c(Sc2cc3c(cc2Br)OCO3)nc2c(N)nccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050032838A1,CCI.COc1cccc(S)c1>>CCSc1cccc(OC)c1,,CCO,,[K+].[OH-],,val
US20080085886A1,CCC(CC)(C(=O)[O-])C(=O)[O-].CCO.O.c1ncncn1>>CCOC(=O)c1cncnc1O,,O,,Cl,[Na],val
US20020188009A1,Cc1nc(-c2ccccc2)c(-c2ccccc2)n1CCCCCC(C(=O)O)(C(=O)O)c1ccccc1>>Cc1nc(-c2ccccc2)c(-c2ccccc2)n1CCCCCC(C(=O)O)c1ccccc1,,CC(=O)O,,,,val
US20140187545A1,Cc1c(CC(C#N)C#N)cccc1C(F)(F)F.NN>>Cc1c(Cc2c(N)n[nH]c2N)cccc1C(F)(F)F,,CCO,,O,,val
US20110166132A1,COC(=O)C(CC1CC1)c1ccc([N+](=O)[O-])cn1>>COC(=O)C(CC1CC1)c1ccc(N)cn1,[Pd],CO,,,,val
US20090202844A1,CC(C)CO.O=C(O)c1ccccc1C(=O)O>>CC(C)Cc1cccc(C(=O)O)c1C(=O)O,,CC(C)CO,,[K+].[OH-],,val
US20110034441A1,Cc1cn(-c2cccc(N)c2[N+](=O)[O-])cn1>>Cc1cn(-c2cccc(N)c2N)cn1,[Pd],CO,,,,val
US20150057240A1,O=[N+]([O-])/C=C/c1ccc(OCc2ccccc2)cc1-c1cccc(F)c1>>NCCc1ccc(OCc2ccccc2)cc1-c1cccc(F)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04242507,O=S(=O)(Cl)c1ccccc1.On1nnc2ccccc21>>O=S(=O)(On1nnc2ccccc21)c1ccccc1,,[Na+],[OH-],,,val
US20130210824A1,Fc1ccccc1CBr.N#Cc1n[nH]c2c1CCC2>>N#Cc1nn(Cc2ccccc2F)c2c1CCC2,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090018103A1,CC(F)(F)CCC[C@@](O)(c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1>>CC(F)(F)CCC[C@@](O)(c1cccc(Cl)c1)[C@@H]1CCCNC1,,CC#N,,Cl,,val
US20090197863A1,COC(=O)c1cccc(NC(=O)c2cccc(C)c2)c1O>>COC(=O)c1cccc2nc(-c3cccc(C)c3)oc12,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100168122A1,CCCCn1c(=O)n(CCCC(=O)OCC)c(=O)c2[nH]c(Cl)nc21.[H]/N=C(/Cc1cccc(Cl)c1Cl)NO>>CCCCn1c(=O)n(CCCc2nc(Cc3cccc(Cl)c3Cl)no2)c(=O)c2[nH]c(Cl)nc21,,CCO,,C,C[O-].[Na+],val
US20120258946A1,CC(C(=O)NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1)c1ccc(C2(O[Si](C)(C)C(C)(C)C)CC2)c(F)c1>>CC(C(=O)NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1)c1ccc(C2(O)CC2)c(F)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140288077A1,CC(C)N=C=O.N[C@H](CO)Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1>>CC(C)NC(=O)N[C@H](CO)Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1,,C1CCOC1,,CN(C)C=O,O,val
US20110193073A1,CC(C)(C)OC(=O)N(CCOCCO)CC(=O)OCc1ccccc1.CI>>COCCOCCN(CC(=O)OCc1ccccc1)C(=O)OC(C)(C)C,,O,,C1CCOC1,[H-].[Na+],val
US20030229089A1,COC(=O)c1c(N2CCC(O)CC2)nc(N2CCn3ccnc3C2)nc1S(=O)Cc1ccccc1.COc1ccc(CN)cc1Cl>>COC(=O)c1c(NCc2ccc(OC)c(Cl)c2)nc(N2CCn3ccnc3C2)nc1N1CCC(O)CC1,,CC(=O)N(C)C,,CCN(CC)CC,,val
US20130012532A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.COC(=O)C[C@@H](C)CO>>COC(=O)C[C@@H](C)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,ClCCl,,O,c1c[nH]cn1,val
US20020016347A1,Cc1ccccc1C(=O)c1ccc(N)cc1Cl.Cn1ccc2cc(Br)ccc21>>Cc1ccccc1C(=O)c1ccc(Nc2ccc3c(ccn3C)c2)cc1Cl,,C1COCCO1,,CC(C)(C)O[Na],,val
US04740513,CCOC(OCC)OCC.Cc1c[nH]cn1>>CCOC(OCC)n1cnc(C)c1,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150353553A1,C[C@@H]1CC[C@@H](Cn2c(N3CCOCC3)nc3nc(/C(N)=N/O)nc(-c4cccc(Cl)c4)c32)CC1.O=C(n1ccnc1)n1ccnc1>>C[C@@H]1CC[C@@H](Cn2c(N3CCOCC3)nc3nc(-c4noc(=O)[nH]4)nc(-c4cccc(Cl)c4)c32)CC1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20070049593A1,COC(=O)c1ccc2c(C3CCCCC3)c(Br)n(CC(C)=O)c2c1.Cc1ccc(B2OC(C)(C)C(C)(C)O2)c(N)c1>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc(C)cc3N)n(CC(C)=O)c2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])O.[Na+],,val
US20140275548A1,CI.OCc1cnc2cc(OCc3cccc(Cl)c3)ccc2c1>>COCc1cnc2cc(OCc3cccc(Cl)c3)ccc2c1,,CN(C)C=O,,[H-].[Na+],,val
US20020160996A1,COc1ccc(C(=O)Cl)cc1.Cc1c(C)c2c(c(C)c1N)C(c1ccc(C(C)C)cc1)C(C)(C)O2>>COc1ccc(C(=O)Nc2c(C)c(C)c3c(c2C)C(c2ccc(C(C)C)cc2)C(C)(C)O3)cc1,,CCCCCC,CCOC(C)=O,,,val
US20140371199A1,CC1(O)CCN(C(=O)c2ccc(Br)cc2)CC1.CI>>COC1(C)CCN(C(=O)c2ccc(Br)cc2)CC1,,CN(C)C=O,,CCCCCC,[H-].[Na+],val
US04602927,Cc1nc[nH]c1Cl.O=C=Nc1cc(Cl)cc(Cl)c1>>Cc1ncn(C(=O)Nc2cc(Cl)cc(Cl)c2)c1Cl,,ClC(Cl)Cl,,,,val
US20090275590A1,COc1cc(Cl)ccc1-c1ccn(-c2ccc3c4c(n(C)c3c2)CN(C)CC4)c(=O)c1.Cl>>COc1cc(Cl)ccc1-c1ccn(-c2ccc3c4c(n(C)c3c2)CN(C)CC4)c(=O)c1.Cl,,ClCCl,,CCOCC,,val
US20040014751A1,Cc1cc(Cl)nc(Cl)c1C(N)=O.O=S(=O)(O)O>>Cc1cc(Cl)nc(Cl)c1C(=O)O,,O,O=S(=O)(O)O,O=N[O-].[Na+],,val
US20070010511A1,COCCCn1ccnc1Br.COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCc2cccc(B3OC(C)(C)C(C)(C)O3)c2)cc1>>COCCCn1ccnc1-c1cccc(COC2CN(C(=O)OC(C)(C)C)CCC2c2ccc(OCCCOCc3ccccc3OC)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US05062884,CCOC(=O)CC#N.O=Cc1cc([N+](=O)[O-])ccc1Cl>>CCOC(=O)C(C#N)=Cc1cc([N+](=O)[O-])ccc1Cl,,C1CCOC1,,C1CCNCC1,CC(=O)O,val
US20080045555A1,CCCCCn1c(=O)nc(SC)c2[nH]c(C(F)(F)F)nc21.NN>>CCCCCn1c(=O)[nH]/c(=N/N)c2[nH]c(C(F)(F)F)nc21,,O,,,,val
US20100183603A1,COC(=O)C(=O)c1cn2c3c(cccc13)CC2.NC(=O)Cc1c[nH]c2ccccc12>>O=C1NC(=O)C(c2cn3c4c(cccc24)CC3)=C1c1c[nH]c2ccccc12,,C1CCOC1,CCOC(C)=O,Cl,CC(C)(C)[O-].[K+],val
US20160039834A1,COc1ccc(C(F)(F)F)c(-c2nc(Cl)c(C)c(-c3c(C)noc3C)n2)c1>>Cc1noc(C)c1-c1nc(-c2cc(O)ccc2C(F)(F)F)nc(Cl)c1C,,ClCCl,,BrB(Br)Br,,val
US20120052757A1,Nc1ccc(O)cc1.O=C(O)c1cc(O)cc(O)c1>>O=C(Nc1ccc(O)cc1)c1cc(O)cc(O)c1,,CN(C)C=O,,,,val
US20140235628A1,CC(=O)OC(C)=O.N#Cc1cc(CCC2(O)CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)ccc1F>>CC(=O)OC1(CCc2ccc(F)c(C#N)c2)CCN(C(=O)Cc2ccc(-n3cnnn3)cc2)CC1,CN(C)c1ccncc1,ClCCl,,,,val
US04306065,Clc1nc(-c2ccccc2)nc2ccccc12.OCC1CCCNC1>>OCC1CCCN(c2nc(-c3ccccc3)nc3ccccc23)C1,,CC(C)O,,,,val
US20080207690A1,COC(=O)C1(CN2CCC(CCOc3noc4cccc(OCc5ccccc5)c34)CC2)CCOCC1>>COC(=O)C1(CN2CCC(CCOc3noc4cccc(O)c34)CC2)CCOCC1,[Pd],C1CCOC1,CO,,,val
US20040006067A1,CC(C)(C)OC(=O)N1CCC(c2ccccc2NC(=O)OCC2c3ccccc3-c3ccccc32)CC1.Cl>>Cl.O=C(Nc1ccccc1C1CCNCC1)OCC1c2ccccc2-c2ccccc21,,CCOC(C)=O,,,,val
US20110053922A1,Cc1cc(F)ccc1[C@H]1C[C@]2(CC[C@@H](C(N)=O)N2)CCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl>>Cc1cc(F)ccc1[C@H]1C[C@]2(CC[C@@H](C(N)=O)N2)CCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl,,CCOCC,CCOCC,,,val
US20090312305A1,COS(=O)(=O)OC.O=Cc1cccc2cc[nH]c12>>Cn1ccc2cccc(C=O)c21,,CN(C)C=O,,[H-].[Na+],,val
US20090093484A1,CCOC(=O)CBr.COc1ccc(O)c2ccoc12>>CCOC(=O)COc1ccc(OC)c2occc12,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130158009A1,CS(=O)(=O)c1cc(F)c(N[C@H]2CCN(C3CCN(C(=O)OCc4ccccc4)CC3)C2=O)cc1F>>CS(=O)(=O)c1cc(F)c(N[C@H]2CCN(C3CCNCC3)C2=O)cc1F,[Pd],CCO,,[H][H],,val
US20140179666A1,O=C1Nc2cc(Cl)ccc2C12CCCC2>>Clc1ccc2c(c1)NCC21CCCC1,,C1CCOC1,,CO,,val
US20090023747A1,COC1(OC)CO[C@@H]2[C@@H](F)CN(C(=O)[C@H](CC(C)C)N[C@@H](c3ccc(-c4csc(N5CCN(C)CC5)n4)cc3)C(F)(F)F)[C@@H]21>>CC(C)C[C@H](N[C@@H](c1ccc(-c2csc(N3CCN(C)CC3)n2)cc1)C(F)(F)F)C(=O)N1C[C@H](F)[C@H]2OCC(=O)[C@H]21,,ClCCl,O=C(O)C(F)(F)F,O,,val
US05504076,COCc1cc(=O)c(OC)co1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COCc1cc(=O)c(OC)cs1,,Cc1ccccc1,,,,val
US20040138065A1,COc1ccc(CC(C#N)C#N)cc1.FC(F)(F)CCBr>>COc1ccc(CC(C#N)(C#N)CCC(F)(F)F)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20160060197A1,CC(C)c1cccc([C@@H](C)C2CC2)c1O.ClCBr>>CC(C)c1cccc([C@@H](C)C2CC2)c1OCCl,,C1CCOC1,,[Na+].[OH-],,val
US20060166990A1,COc1ccc(N=C=O)cc1.Cc1ccc(N)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl>>COc1ccc(NC(=O)Nc2ccc(C)c(C(=O)c3ccc(Nc4ccc(F)cc4F)cc3Cl)c2)cc1,,C1COCCO1,,,,val
US20110028507A1,COC(=O)CN(Cc1ccc(OC)cc1OC)Cc1c(-c2ccccc2)coc1C(=O)OC>>COC(=O)C1C(=O)c2occ(-c3ccccc3)c2CN1Cc1ccc(OC)cc1OC,,C1CCOC1,,Cl,,val
US20060247283A1,CC(=O)OCCCCOc1c(Cl)cc(OCc2ccccc2)cc1Cl>>CC(=O)OCCCCOc1c(Cl)cc(O)cc1Cl,[Pd],CCO,,[H][H],,val
US04246429,CCOC(=O)C(Nc1ccc(Br)cc1)c1c(Cl)ccc(Cl)c1Cl.O=C(Cl)CCl>>CCOC(=O)C(c1c(Cl)ccc(Cl)c1Cl)N(C(=O)CCl)c1ccc(Br)cc1,,Cc1ccccc1,,,,val
US08334292B1,Cc1ccc(S(=O)(=O)O[C@H]2CCOC2)cc1.Oc1ccc(Br)cc1>>Brc1ccc(O[C@@H]2CCOC2)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US05401772,COc1ccc(Oc2c(Cl)cc([N+](=O)[O-])cc2Cl)cc1C(C)C>>CC(C)c1cc(Oc2c(Cl)cc([N+](=O)[O-])cc2Cl)ccc1O,,ClCCl,,BrB(Br)Br,,val
US20100160322A1,CC(C)(C)OC(=O)N1CCC(N)CC1.NS(=O)(=O)c1ccc(Cl)c([N+](=O)[O-])c1>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(S(N)(=O)=O)cc2[N+](=O)[O-])CC1,,C1COCCO1,,CCN(CC)CC,,val
US04855453,CCOC(=O)c1cc2c(C=O)cc3c4ccccc4ccc3c2o1>>O=Cc1cc2c3ccccc3ccc2c2occc12,,O,,C1CCOC1,Cl,val
US04713387,C/C(=C\c1ccc(Cc2cccnc2)cc1)CO.O=S(Cl)Cl>>C/C(=C\c1ccc(Cc2cccnc2)cc1)CCl.Cl,,ClCCl,,,,val
US03939202,CC(C)=CCCC(C)=CCCC(C)C=O.CCOC(=O)CBr>>CCOC(=O)CC(O)C(C)CCC=C(C)CCC=C(C)C,[Zn],c1ccccc1,,O=S(=O)(O)O,,val
US20100324047A1,Cc1c(Br)cc2c(=O)[nH]cnc2c1[N+](=O)[O-]>>Cc1ccc2c(=O)[nH]cnc2c1N,,CCO,,,,val
US06207693B1,CCOC(=O)c1cc2c(C(=O)Nc3ccc(C(=O)N(C)c4ccc(C)cc4OCCCCCC(=O)N4CCN(C)CC4)cc3OC)cccc2n1C(=O)OC(C)(C)C>>CCOC(=O)c1cc2c(C(=O)Nc3ccc(C(=O)N(C)c4ccc(C)cc4OCCCCCC(=O)N4CCN(C)CC4)cc3OC)cccc2[nH]1,,O=C(O)C(F)(F)F,,,,val
US20150282482A1,COC(=O)c1sc2ccc(C(F)(F)F)cc2c1N.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1sc2ccc(C(F)(F)F)cc2c1NC(=O)C(F)(F)F,,COC(C)(C)C,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20060178400A1,C#CC(C)NC(C)=O.COc1ccc2ccc(Oc3ncc(Br)s3)cc2c1>>COc1ccc2ccc(Oc3ncc(C#CC(C)NC(C)=O)s3)cc2c1,,C1CCOC1,,CCN(CC)CC,,val
US05932567,COc1cc(C#N)ccc1CNC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C>>COc1cc(C#N)ccc1CNC(=O)[C@@H]1CCCN1,,ClCCl,,,,val
US05935952,CCCC[Sn](CCCC)(CCCC)c1ccc2c(c1)CN(S(=O)(=O)c1ccc(C)cc1)C2.CCOC(=O)c1cn(C2CC2)c2c(C)c(Br)c(F)cc2c1=O>>CCOC(=O)c1cn(C2CC2)c2c(C)c(-c3ccc4c(c3)CN(S(=O)(=O)c3ccc(C)cc3)C4)c(F)cc2c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US05216177,CC(C)=CBr.C[C@@H](CC(=O)[O-])[C@H]1CO1>>CC(C)=CC[C@H]1OC(=O)C[C@@H]1C,Br[Cu]Br,C1CCOC1,,[Mg],,val
US05324747,CCOCCOCCOCCOc1cc(OCCCCCCCCCCCCOc2ccccc2)cc(N(CC(=O)O)CC(=O)O)c1.CCOCCOCCOCCOc1cc(OCCCCCCCCCCCCOc2ccccc2)cc(N(CC(=O)OC)CC(=O)OC)c1>>CCOCCOCCOCCOc1ccc(OCCCCCCCCCCCCOc2ccccc2)cc1N(CC(=O)O)CC(=O)O,,C1COCCO1,CO,[Na+].[OH-],,val
US06262056B1,C=O.CC(=O)c1csc2ccc(C)cc12.COc1ccccc1N1CCNCC1.Cl.Cl>>COc1ccccc1N1CCN(CCC(=O)c2csc3ccc(C)cc23)CC1.Cl.Cl,,CCO,CCOCC,,,val
US06440899B1,CC1(C)CCS(=O)(=O)c2c1ccc(C(=O)C1=C(Cl)CCCC1=O)c2Cl.Sc1ccccc1>>CC1(C)CCS(=O)(=O)c2c1ccc(C(=O)C1=C(Sc3ccccc3)CCCC1=O)c2Cl,,C1CCOC1,,CCN(CC)CC,O,val
US20120232068A1,N#CC1(c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)CC1>>NCC1(c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)CC1,[Ni],CO,N,,,val
US20060040999A1,COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN(CC(N=[N+]=[N-])c1ccc(Cl)cc1)C(=O)OCc1ccccc1>>COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN(CC(N)c1ccc(Cl)cc1)C(=O)OCc1ccccc1,O=[Pt]=O,C1CCOC1,,,,val
US20070149574A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc(CO)ccn1>>CC(C)(C)OC(=O)Nc1cc(CO)ccn1,,CC(C)(C)O,,,,val
US04144047,CCOC(=O)CC#N.FC(F)(F)c1ccc(Br)cc1>>CCOC(=O)C=C(N)c1ccc(C(F)(F)F)cc1,,CCOCC,,[Mg],,val
US20120264748A1,Cc1ccc(S(=O)(=O)n2ccc3c(CN4C(=O)CCCC45CCNCC5)cccc32)cc1.Clc1cnc2ccccc2n1>>Cc1ccc(S(=O)(=O)n2ccc3c(CN4C(=O)CCCC45CCN(c4cnc6ccccc6n4)CC5)cccc32)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060293298A1,CC(C)N1CCC(Oc2ccc(C3CCN(C(=O)OCc4ccccc4)CC3)cc2)CC1>>CC(C)N1CCC(Oc2ccc(C3CCNCC3)cc2)CC1,[Pd],CCO,,,,val
US20150266900A1,NCc1ccccc1.NS(=O)(=O)c1c(F)c(F)c(S(=O)(=O)CCO)c(F)c1F>>NS(=O)(=O)c1c(F)c(F)c(S(=O)(=O)CCO)c(NCc2ccccc2)c1F,,CO,,,,val
US20130029987A1,CSc1nc(NC(C)(C)C)ncc1C#N.OO>>CSc1nc(NC(C)(C)C)ncc1C(N)=O,,CS(C)=O,,O,[Na+].[OH-],val
US20090005433A1,CC=O.NC(COC(F)F)C(=O)NCc1ccccc1>>CC(=O)NC(COC(F)F)C(=O)NCc1ccccc1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US05223498,O=C(O)/C=C/C(=O)O.c1ccc(N2CCOCC2)c(N=C2CCCCN2)c1>>O=C(O)/C=C/C(=O)O.c1ccc(N2CCOCC2)c(N=C2CCCCN2)c1,,CO,,,,val
US20050222207A1,COc1ccc(N(Cc2cccnc2)c2cccc(C(=O)OC(C)(C)C)c2)nc1OC1CCCC1>>COc1ccc(N(Cc2cccnc2)c2cccc(C(=O)O)c2)nc1OC1CCCC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20130236434A1,COC(=O)C[C@H](N)c1ccc2c(c1)OCO2.O=C=NCCOC(=O)N(Cc1cccs1)Cc1cccs1>>COC(=O)C[C@H](NC(=O)NCCOC(=O)N(Cc1cccs1)Cc1cccs1)c1ccc2c(c1)OCO2,,ClCCl,,,,val
US05180735,COC1C(N)CCC(O)(CSCc2ccccc2CO)C1C1(C)OC1CC=C(C)C.O=C=NC(=O)CCl>>COC1C(NC(=O)NC(=O)CCl)CCC(O)(CSCc2ccccc2CO)C1C1(C)OC1CC=C(C)C,,ClCCl,,O,,val
US20110015173A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H]1CC[C@@H](Nc2cc(I)cc(Cl)n2)CC1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](Nc2cc(I)cc(Cl)n2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20070191336A1,CC(C)(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2ccc(CO)cc2)n1>>CC(C)(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2ccc(C=O)cc2)n1,O=[Mn]=O,ClCCl,,,,val
US20020115826A1,NO.O=C(Cl)c1ccc(Oc2ccccc2)cc1.O=C(Cl)c1ccccc1>>O=C(CCCCCCC(=O)c1ccc(Oc2ccccc2)cc1)NO,,CCN(CC)CC,,Cl,,val
US20070197617A1,CC(C)(C)CC(N)C(=O)Nc1ccc(I)cc1F.CC(C)(C)OCCOc1ccc([C@@H](NC(=O)OC(C)(C)C)C(=O)O)cc1>>CC(C)(C)C[C@H](NC(=O)[C@H](NC(=O)OC(C)(C)C)c1ccc(OCCOC(C)(C)C)cc1)C(=O)Nc1ccc(I)cc1F,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US20140045862A1,COCn1cc([C@H]2CCC(F)(F)C[C@@H]2Oc2ccc(S(=O)(=O)N(Cc3ccc(OC)cc3OC)c3ccncn3)c(F)c2)cn1>>O=S(=O)(Nc1ccncn1)c1ccc(O[C@H]2CC(F)(F)CC[C@@H]2c2cn[nH]c2)cc1F,,ClCCl,O=C(O)C(F)(F)F,CC[SiH](CC)CC,,val
US20090096314A1,O=C([O-])Cc1ccccc1Nc1c(Cl)cccc1Cl.OCCCCO>>O=C(Cc1ccccc1Nc1c(Cl)cccc1Cl)OCCCCO,,Cc1ccccc1,,O=S(=O)(O)O,,val
US06346621B1,CN(C)C=O.ClCc1c(Cl)cccc1Cl>>O=CCc1c(Cl)cccc1Cl,,CCOCC,,Cl,[Mg],val
US20140162971A1,BrP(Br)Br.OCc1ccc(Oc2ccc(F)cc2F)c(Br)c1>>Fc1ccc(Oc2ccc(CBr)cc2Br)c(F)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US20070161673A1,Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(N)n[nH]c2n1.O=S(=O)(Cl)c1cccs1>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(NS(=O)(=O)c3cccs3)n[nH]c2n1,,c1ccncc1,,,,val
US06538152B1,C=Cc1ccc(OCc2ccccc2)c(C(=O)OC)c1.OO>>COC(=O)c1cc(CCO)ccc1OCc1ccccc1,,C1CCOC1,O,B1C2CCCC1CCC2,[Na+].[OH-],val
US20080167303A1,O=S1(=O)N(CCC2CNCCO2)c2ccccc2N1c1ccccc1>>O=S1(=O)N(CC[C@@H]2CNCCO2)c2ccccc2N1c1ccccc1,,CC#N,CO,,,val
US20160120850A1,CC[C@H](NS(=O)(=O)c1ccc(-c2sc(-c3nnc(CC(C)(C)C(=O)OC)o3)nc2CN2CCCC(F)(F)C2)c(Cl)c1Cl)C(F)(F)F>>CC[C@H](NS(=O)(=O)c1ccc(-c2sc(-c3nnc(CC(C)(C)C(=O)O)o3)nc2CN2CCCC(F)(F)C2)c(Cl)c1Cl)C(F)(F)F,,CO,O,[Li]O,,val
US20090221654A1,CC(C)OC(=O)CCC/C=C\C[C@H]1[C@@H](OC2CCCCO2)C[C@H](F)[C@@H]1/C=C/[C@@H](O)C1Cc2ccccc2C1>>CC(C)OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H](F)[C@@H]1/C=C/[C@@H](O)C1Cc2ccccc2C1,,CC(C)O,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140038989A1,CCOC(=O)c1cnn2c1N[C@@H](c1ccc(CC)cc1)C[C@H]2C(F)(F)F>>CCc1ccc([C@H]2C[C@@H](C(F)(F)F)n3ncc(C(=O)O)c3N2)cc1,,CCO,,[K+].[OH-],,val
US20010014684A1,COCCOCN(c1onc(C)c1Cl)S(=O)(=O)c1c(C(=O)c2ccc3c(c2)OCO3)sc2ncccc12>>Cc1noc(NS(=O)(=O)c2c(C(=O)c3ccc4c(c3)OCO4)sc3ncccc23)c1Cl,,CO,Cl,,,val
US20050130964A1,O=C(CCl)c1ccccc1.Oc1ccc2ccccc2c1>>CC(=O)c1ccccc1Oc1ccc2ccccc2c1,Cl[Cu],CC(C)CCO,,O=C([O-])[O-].[K+].[K+],,val
US20150141444A1,COc1ccc(Cc2cc3c(=O)n([C@H]4CCCC[C@@H]4O)cnc3c3c2C=CCN3C)cc1>>CN1CC=Cc2c(Cc3ccc(O)cc3)cc3c(=O)n([C@H]4CCCC[C@@H]4O)cnc3c21,,ClCCl,,BrB(Br)Br,,val
US20060160872A1,OB(O)c1ccccc1.Oc1ccc2cccc(Nc3nc4cc(Br)ccc4[nH]3)c2c1>>Oc1ccc2cccc(Nc3nc4cc(-c5ccccc5)ccc4[nH]3)c2c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20030166639A1,Cc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccnc(N4CCCC4)c3)c2)cc1C(F)(F)F>>Cc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3ccnc(N4CCCC4)c3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140296067A1,Cc1cnc(Cl)cc1Cl.O=C1CCC(=O)N1Br>>Clc1cc(Cl)c(CBr)cn1,CC(C)(C#N)N=NC(C)(C)C#N,Clc1ccccc1,,,,val
US20160168123A1,Cc1cnn(Cc2ccc(C(=O)c3cncc(Br)c3)cc2)c1.N#C[Zn]C#N>>Cc1cnn(Cc2ccc(C(=O)c3cncc(C#N)c3)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(=O)N(C)C,ClCCl,,,val
US20150218176A1,O=C1CCC(=O)N1I.c1cc2nc(-c3cn[nH]c3)cnc2[nH]1>>Ic1c[nH]c2ncc(-c3cn[nH]c3)nc12,,CC(C)=O,,,,val
US20090286790A1,CCC1CC(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(Cc2ccccc2)N1C(=O)OCc1ccccc1.COC(=O)Cl>>CCC1CC(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)OC)CC(Cc2ccccc2)N1C(=O)OCc1ccccc1,,ClCCl,,,,val
US20160244437A1,CC(=O)Nc1ccc(Cl)c(-c2cccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CNC(=O)OC(C)(C)C)CC3)C(=O)Nc3ccc(-c4nnn[nH]4)cc3)c2)c1.Cl>>CC(=O)Nc1ccc(Cl)c(-c2cccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CN)CC3)C(=O)Nc3ccc(-c4nnn[nH]4)cc3)c2)c1.Cl,,C1COCCO1,,CC#N,,val
US20140315961A1,CCOC(=O)c1[nH]cnc1Br.C[Si](C)(C)CCOCCl>>CCOC(=O)c1c(Br)ncn1COCC[Si](C)(C)C,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20120264749A1,CC(=O)CNC(=O)C1CN(CC(F)(F)F)CC2(CCN(C(=O)OC(C)(C)C)CC2)O1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>Cc1cnc(C2CN(CC(F)(F)F)CC3(CCN(C(=O)OC(C)(C)C)CC3)O2)s1,,C1CCOC1,,,,val
US20150361079A1,CCI.COc1ccc(N2C(=O)c3ccc(C(=O)O)cc3NC23CCN(Cc2ccc(F)c(F)c2)CC3)cc1>>CCOC(=O)c1ccc2c(c1)NC1(CCN(Cc3ccc(F)c(F)c3)CC1)N(c1ccc(OC)cc1)C2=O,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US05292887,CI.OCC1(c2cn(Cc3ccccc3)cn2)Cc2ccccc2C1>>COCC1(c2cn(Cc3ccccc3)cn2)Cc2ccccc2C1,,C1CCOC1,,[H-].[Na+],,val
US20070161791A1,CCO.COc1cc2nc(N3CCN(C(=O)C4CCCO4)CC3)nc(N)c2cc1OC.Cl.O>>COc1cc2nc(N3CCN(C(=O)C4CCCO4)CC3)nc(N)c2cc1OC.Cl.O.O,,O,,,,val
US20160221972A1,COC(=O)c1ccc(C)c(Cl)n1.O=C1CCC(=O)N1Br>>COC(=O)c1ccc(CBr)c(Cl)n1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20090203681A1,CC(=O)OC(C(=O)O)c1ccc(Br)cc1.Nc1ccc(C(F)(F)F)cc1>>CC(=O)OC(C(=O)Nc1ccc(C(F)(F)F)cc1)c1ccc(Br)cc1,,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20110300174A1,CN1CCC[C@H]1c1cncc(OCCNC(=O)[C@@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)c1>>CN1CCC[C@H]1c1cncc(OCCNC(=O)[C@@H]2CC[C@@H](N)CC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090111983A1,CCOC(=O)[C@@H](N)C(C)C.O=C1OC(c2ccco2)=NC12CCCCC2>>CCOC(=O)[C@@H](NC(=O)C1(NC(=O)c2ccco2)CCCCC1)C(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US04975439,COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCC(=O)N2CCC3(CC2)OCCO3)C[C@H]1OC>>COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCC(=O)N2CCC(=O)CC2)C[C@H]1OC,,O,,O=S(=O)(O)O,O=C([O-])[O-].[Na+].[Na+],val
US20150045348A1,CC1CN(Cc2ccccc2)CC1c1nn2c(I)ncc2c(=O)[nH]1.OB(O)c1ccc(F)cc1>>CC1CN(Cc2ccccc2)CC1c1nn2c(-c3ccc(F)cc3)ncc2c(=O)[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20160090387A1,CC[C@@H](N)CO.Cn1cnc2c(NCC3CC3)nc(Cl)nc21>>CC[C@H](CO)Nc1nc(NCC2CC2)c2ncn(C)c2n1,,O,,CCOCC,,val
US20110212923A1,C=Cc1cc(O)cc2nc(-c3ccc(O)c(F)c3)oc12.CCOP(=O)(Cl)OCC>>C=Cc1cc(O)cc2nc(-c3ccc(OP(=O)(OCC)OCC)c(F)c3)oc12,,CC#N,,CCN(C(C)C)C(C)C,,val
US20110201599A1,CN(C)/C=C/C(=O)c1cn(S(=O)(=O)c2ccccc2)c2nccc(Cl)c12.N=C(N)N>>Nc1nccc(-c2c[nH]c3nccc(Cl)c23)n1,,COCCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120220575A1,NC1CCOC1.O=C(O)CN1C[C@@H]2COCCN2c2nc(Cl)ncc21>>O=C(CN1C[C@@H]2COCCN2c2nc(Cl)ncc21)NC1CCOC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030158188A1,Nc1cccc2[nH]ccc12.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C=Nc1cccc2[nH]ccc12,,Cc1ccccc1,,,,val
US20050049252A1,C#CCCCCl.CCOC(=O)C1=Cc2cc(Cl)cc(I)c2OC1C(F)(F)F>>CCOC(=O)C1=Cc2cc(Cl)cc(C#CCCCCl)c2OC1C(F)(F)F,[Cu]I,CCOCC,Cc1ccccc1,CCN(CC)CC,,val
US04395406,CCI.O=c1[nH]cc(F)c(=S)[nH]1>>CCSc1nc(=O)[nH]cc1F,,CO,,[K],,val
US20040138286A1,O=C(OCc1ccccc1)N1CCC(S(=O)(=O)Nc2ccc3c(cnn3C3CCCCO3)c2)CC1>>O=C(OCc1ccccc1)N1CCC(S(=O)(=O)Nc2ccc3[nH]ncc3c2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140135292A1,CC(C)(C)[Si](OCc1cn(COCC[Si](C)(C)C)c(-c2ccon2)n1)(c1ccccc1)c1ccccc1>>C[Si](C)(C)CCOCn1cc(CO)nc1-c1ccon1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100094000A1,CC1(C)OB(c2ccc3c(c2)NC(=O)CO3)OC1(C)C.Cc1nn(Cc2cccnc2)c(-c2ccc(F)cc2)c1Br>>Cc1nn(Cc2cccnc2)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100121054A1,C=NCc1ccc(Cl)nc1>>NCc1ccc(Cl)nc1,,O,,Cc1ccccc1,Cl,val
US05707991,CC(C)(C)OC(=O)C1CC(S(=O)(=O)c2ccccc2)C(c2ccccc2F)N1C(=O)CNC(=O)Nc1cccc(CC(=O)OCc2ccccc2)c1>>CC(C)(C)OC(=O)C1CC(S(=O)(=O)c2ccccc2)C(c2ccccc2F)N1C(=O)CNC(=O)Nc1cccc(CC(=O)O)c1,[Pd],CCO,,,,val
US20100152183A1,CC(C)(C)OC(=O)N1CC[C@@H](N)C1.NS(=O)(=O)c1ccc(F)c([N+](=O)[O-])c1>>CC(C)(C)OC(=O)N1CC[C@@H](Nc2ccc(S(N)(=O)=O)cc2[N+](=O)[O-])C1,,CN(C)C=O,,C1CCOC1,CCN(C(C)C)C(C)C,val
US20140005382A1,CC(C)(C)c1ccc(C=O)cc1.C[Mg]Br>>CC(O)c1ccc(C(C)(C)C)cc1,,CCOCC,,[Cl-].[NH4+],,val
US04728645,CC(C)(C)NC(=O)c1ccc(Br)cc1.O=CCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CC(C)(C)NC(=O)c1ccc(C(O)CCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20100272678A1,CC(=O)C(C)(C)C.CN(C)C=O.Cl.NO>>CC(C)(C)C(Cl)=CC#N,,O,,O=P(Cl)(Cl)Cl,,val
US20040048857A1,CCCCCCc1ccc(-c2ccc(CCC(COC(C)=O)(COC(C)=O)NC(C)=O)cc2)cc1>>CCCCCCc1ccc(-c2ccc(CCC(N)(CO)CO)cc2)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US04764610,N.O=S(=O)(Cl)c1cc2ccccc2n1S(=O)(=O)c1ccccc1>>NS(=O)(=O)c1cc2ccccc2n1S(=O)(=O)c1ccccc1,,C1CCOC1,,,,val
US20090076062A1,COCCCBr.Cc1ccc(Br)cc1O>>COCCCOc1cc(Br)ccc1C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090269301A1,CCOC(=O)C(=O)Cc1c[nH]c2ccccc12.Nc1ccc2[nH]cnc2c1.O=Cc1cnc2ccccc2c1>>O=C1C(O)=C(c2c[nH]c3ccccc23)C(c2cnc3ccccc3c2)N1c1ccc2[nH]cnc2c1,,CCO,,,,val
US20100130545A1,CC(C)(C)C(=O)Cl.COc1cccc2[nH]c(CCCN(C)CCC3(O)CC4CCC3C=C4c3ccccc3)nc12>>COc1cccc2[nH]c(CCCN(C)CC[C@]3(OC(=O)C(C)(C)C)C[C@H]4CC[C@@H]3C=C4c3ccccc3)nc12,CN(C)c1ccncc1,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20070010670A1,CCS(=O)(=O)c1ccc(O)c(NC(=O)CCl)c1>>CCS(=O)(=O)c1ccc2c(c1)NC(=O)CO2,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150051395A1,COC(=O)c1ncc(N)cc1F.O=S(=O)(Cl)c1ccc(Br)cn1>>COC(=O)c1ncc(NS(=O)(=O)c2ccc(Br)cn2)cc1F,,ClCCl,,c1ccncc1,,val
US20090099187A1,COc1ccc(S(=O)(=O)Cl)c2c1C[C@@H](NC(=O)C(F)(F)F)CC2.Nc1cccc(C(F)(F)F)c1>>COc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)c2c1C[C@@H](NC(=O)C(F)(F)F)CC2,,ClCCl,,c1ccncc1,,val
US20060183909A1,COC(=O)c1cc(NS(=O)(=O)c2ccc(C)cc2)c2cccc(OCc3ccccc3)c2n1>>COC(=O)c1cc(NS(=O)(=O)c2ccc(C)cc2)c2cccc(O)c2n1,[Pd],CC(=O)O,,CCOC(C)=O,CO,val
US20080021029A1,Cc1ccnc(Cl)c1.O=C1CCC(=O)N1Cl>>ClCc1ccnc(Cl)c1,,CC#N,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20070203156A1,COC(=O)c1cccnc1-c1cnc(C(=O)CCCCCCc2ccccc2)o1>>O=C(CCCCCCc1ccccc1)c1ncc(-c2ncccc2C(=O)O)o1,,CC(=O)O,CCOC(C)=O,,,val
US05041455,N#CC(=NO)c1cccnc1.NO>>NC(=NO)C(=NO)c1cccnc1,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20020103229A1,N#Cc1ccc2c(c1)c(-c1cc3ccccc3o1)nn2C1CCCCO1>>N#Cc1ccc2[nH]nc(-c3cc4ccccc4o3)c2c1,,CO,,Cl,,val
US20140194431A1,CC(C)N1CCn2c(Cc3ccccc3Br)nc(=O)c(OCc3ccccc3)c2C1=O.OB(O)c1ccc(Cl)c(Cl)c1>>CC(C)N1CCn2c(Cc3ccccc3-c3ccc(Cl)c(Cl)c3)nc(=O)c(O)c2C1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20120178770A1,CC1(C)OB(c2cccc(N)c2)OC1(C)C.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>CC1(C)OB(c2cccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c2)OC1(C)C,,ClCCl,,,,val
US20070275952A1,CC(C)(C)OC(=O)N1CCNCC1.Clc1nsnc1Cl>>CC(C)(C)OC(=O)N1CCN(c2nsnc2Cl)CC1,,CN(C)C=O,O,Cl,,val
US20100173901A1,CC(C)Br.CC1(C)OB(c2cn[nH]c2)OC1(C)C>>CC(C)n1cc(B2OC(C)(C)C(C)(C)O2)cn1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060122256A1,CCOC(=O)c1csc(CBr)n1.Oc1ccc(I)cc1>>CCOC(=O)c1csc(COc2ccc(I)cc2)n1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06211375B1,CCOC(=O)c1cn(-c2cc(NC(=O)OC(C)(C)C)c(F)cc2F)c2c(C)c(F)c(F)c(C)c2c1=O>>Cc1c(F)c(F)c(C)c2c1c(=O)c(C(=O)O)cn2-c1cc(N)c(F)cc1F,,Cl,,,,val
US20040122235A1,CC(C)Nc1ccccc1Oc1ccccc1.Nc1nccs1.O=C(n1ccnc1)n1ccnc1>>CC(C)N(C(=O)Nc1nccs1)c1ccccc1Oc1ccccc1,,CC(Cl)Cl,,,,val
US04385059,NC(=S)c1ccc(O)cc1.O=C(O)CC(Br)C(=O)c1ccc(Cl)cc1>>O=C(O)Cc1sc(-c2ccc(O)cc2)nc1-c1ccc(Cl)cc1,,CN(C)C=O,,,,val
US20080039639A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC[C@H]1CCc2ccccc2O1>>CC(C)(C)OC(=O)NC[C@H]1CCc2ccccc2O1,,ClCCl,,,,val
US04960775,CCOC(=O)CC(=O)CC(O)/C=C/c1c(-c2ccccc2)c2c3ccccc3cnn2c1C(C)C>>CCOC(=O)CC(O)CC(O)/C=C/c1c(-c2ccccc2)c2c3ccccc3cnn2c1C(C)C,,O,,CO,[BH4-].[Na+],val
US20140371199A1,CC(=O)N1CCNCC1.N#Cc1ccc(-c2cnn3ccc(-c4ccc(C(=O)O)cc4)nc23)cc1>>CC(=O)N1CCN(C(=O)c2ccc(-c3ccn4ncc(-c5ccc(C#N)cc5)c4n3)cc2)CC1,,CCOC(C)=O,CN(C)C=O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130072473A1,CC(=O)Nc1cc2c(cc1-c1nc3ccccc3s1)CCNC2.CC=O>>CCN1CCc2cc(-c3nc4ccccc4s3)c(NC(C)=O)cc2C1,,CC(Cl)Cl,O,CC(=O)O,O=C([O-])O.[Na+],val
US05059609,O=C1c2cc(OCc3ccccc3)ccc2OCC1Oc1ccccc1>>Oc1ccc2c(c1)[C@H](O)[C@H](Oc1ccccc1)CO2,[Pd],C1CCOC1,,CO,,val
US20090291917A1,NCc1ccccc1.O=C(O)c1ccc(Oc2ccc3c(c2)COB3O)cc1>>O=C(NCc1ccccc1)c1ccc(Oc2ccc3c(c2)COB3O)cc1,CN(C)c1ccncc1,ClCCl,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20040171743A1,C=C(C)C(=O)OC.C=C(C)C(=O)OCCOC(=O)CC(C)=O>>C=C(C)C(=O)OC.C=C(C)C(=O)OCCOC(=O)CC(C)=O,,C1CCOC1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20140315888A1,Clc1nc2cc(Br)cnc2nc1N1CCN2CCCC2C1.NN>>NNc1nc2cc(Br)cnc2nc1N1CCN2CCCC2C1,,CCO,,CCOCC,O,val
US20100197619A1,C1COCCN1.C=O.COc1c(O)cc(O)c2c(=O)cc(-c3ccccc3)oc12>>COc1c(O)c(CN2CCOCC2)c(O)c2c(=O)cc(-c3ccccc3)oc12,,CO,,,,val
US20140057914A1,C1=COCCC1.OCc1ccnc(Cl)c1>>Clc1cc(COC2CCCCO2)ccn1,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070191364A1,C[C@@H]1CN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)OC(C)(C)C)CC[C@H]1N(C(=O)N(C)C)C1CCCCC1>>C[C@@H]1CN(C(=O)[C@H](N)Cc2ccc(Cl)cc2)CC[C@H]1N(C(=O)N(C)C)C1CCCCC1,,C1COCCO1,,Cl,,val
US20080274892A1,CC(C)COC(=O)Cl.Cc1cn(Cc2ccccc2NS(=O)(=O)C(F)(F)F)c(=O)o1>>Cc1cn(Cc2ccccc2N(C(=O)OCC(C)C)S(=O)(=O)C(F)(F)F)c(=O)o1,,CC#N,,O=C([O-])O.[Na+],,val
US20070219214A1,CCOC(=O)C1(N)CCN(Cc2ccccc2)CC1.O=C(Cl)CCCCl>>CCOC(=O)C1(NC(=O)CCCCl)CCN(Cc2ccccc2)CC1,,ClCCl,,c1ccncc1,O=C([O-])O.[Na+],val
US20110166348A1,CC(C)(C)OC(=O)N1CCO[C@@H](COc2cccc3c2CC=C3)C1.O=S(=O)(O)c1ccccc1>>C1=Cc2cccc(OC[C@H]3CNCCO3)c2C1.O=S(=O)(O)c1ccccc1,,CCOC(C)=O,,,,val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)O)cc1.Nc1ccc(-c2c[nH]cn2)cc1>>Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3c[nH]cn3)cc2)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120010190A1,Cn1cc(C(=O)CC(c2ccc(C(=O)O)cc2)c2ccc(Cl)cc2F)ccc1=O.NC[C@@H](O)CO>>Cn1cc(C(=O)CC(c2ccc(C(=O)NC[C@@H](O)CO)cc2)c2ccc(Cl)cc2F)ccc1=O,,C1CCOC1,,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,,val
US04959293,CC(C)(C)[Si](C)(C)Cl.OC1CCCC2C(O)CCCC12>>CC(C)(C)[Si](C)(C)OC1CCCC2C(O)CCCC12,,C1CCOC1,,CCOCC,[H-].[Na+],val
US20100010053A1,CCOC(=O)CCc1c[nH]c2c(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)ccc(F)c12>>CC(C)Oc1ccc(-c2nc(-c3ccc(F)c4c(CCC(=O)O)c[nH]c34)no2)cc1Cl,,C1CCOC1,O,Cl,[Na+].[OH-],val
US05399578,CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1)[C@H](C(=O)OCc1ccccc1)C(C)C>>CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)OCc1ccccc1)C(C)C,,C1COCCO1,,Cl,,val
US20130096150A1,CC(=O)Cl.COC(=O)[C@H](Cc1ccc(-c2ccc(C#N)cc2)cc1)NC(=O)C1Cc2cc3c(cc2CN1C(=O)OC(C)(C)C)O[C@@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)CN3>>COC(=O)[C@H](Cc1ccc(-c2ccc(C#N)cc2)cc1)NC(=O)C1Cc2cc3c(cc2CN1C(=O)OC(C)(C)C)O[C@@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)CN3C(C)=O,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20110183939A1,CC(=O)C1(C)COC(C)(C)OC1.COC(=O)C(=O)OC>>COC(=O)C(=O)CC(=O)C1(C)COC(C)(C)OC1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20110098330A1,Br[Mg]c1ccccc1.Cc1cccc(C(=O)c2cncn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1C>>Cc1cccc(C(O)(c2ccccc2)c2cncn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1C,,ClCCl,,,,val
US20160200666A1,CC1=C(Nc2ccc(C(=O)O)cc2Cl)CCCC1=O.COc1ccccc1N>>COc1ccccc1NC(=O)c1ccc(NC2=C(C)C(=O)CCC2)c(Cl)c1,,CCOC(C)=O,,,,val
US20130022912A1,C=C(C)C(=O)OC12CC3CC(CC(O)(C3)C1)C2.CCOC(C)=O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>C=C(C)C(=O)OCC(=O)OC12CC3CC(C1)CC(OC(=O)C(F)(F)F)(C3)C2,,CCOC(C)=O,,C1CCOC1,O=C([O-])O.[Na+],val
US20050176717A1,Cl[Mg]Cc1ccccc1.Clc1nc2ccccc2nc1Cl>>Clc1nc2ccccc2nc1Cc1ccccc1,,C1CCOC1,ClCCl,,,val
US05278175,CCc1nc(Cl)nc(Cl)c1F.O>>CCc1nc(Cl)[nH]c(=O)c1F,,O,,[Na+].[OH-],,val
US20130059834A1,CCCC[Sn](Cl)(CCCC)CCCC.Fc1ccc2c(I)n[nH]c2c1>>CCCC[Sn](CCCC)(CCCC)c1n[nH]c2cc(F)ccc12,,C1CCOC1,,CC(C)[Mg]Cl,,val
US06143908,CC(=O)OC[C@H]1COC(C)(C)O1>>CC1(C)OC[C@H](CO)O1,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US20070043064A1,CCS(=O)(=O)N(C)c1cccc(C(=O)C=CN(C)C)c1.Nc1[nH]ncc1[N+](=O)[O-]>>CCS(=O)(=O)N(C)c1cccc(-c2ccnc3c([N+](=O)[O-])cnn23)c1,,CC(=O)O,,CCOC(C)=O,,val
US06083961,CC(=O)OC(C)=O.Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CN)c3Cl)cccc2n1C>>CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3c2nc(C)n3C)c1Cl,,ClCCl,,c1ccncc1,,val
US20090156610A1,C=C(N=Cc1cc(Cl)ccc1OC1CCOCC1)O[Si](C)(C)C.CC(C)(C)OC(=O)N1C(=O)/C(=C\c2cccc(Cl)c2)c2ccc(Cl)cc21>>O=C1CC(c2cccc(Cl)c2)C2(CN1)C(=O)Nc1ccccc12,,ClCCl,,Cc1ccccc1,O=C(O)C(F)(F)F,val
US20130085164A1,CC(=O)c1ccc(-c2ccc(=O)n(C)c2)s1>>CC(O)c1ccc(-c2ccc(=O)n(C)c2)s1,,C1CCOC1,CO,[BH4-].[Na+],,val
US05576340,CC(=O)CBr.CCOC(=O)C(C(=O)OCC)C(C(=O)OCC)(C(=O)OCC)c1ccc(O)cc1>>CCOC(=O)C(C(=O)OCC)C(C(=O)OCC)(C(=O)OCC)c1ccc(OCC(C)=O)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120252758A1,BrCCBr.Oc1ccccc1-c1csc(C(F)(F)F)n1>>FC(F)(F)c1nc(-c2ccccc2OCCBr)cs1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110136764A1,CCOP(=O)(OCC)c1cccc([N+](=O)[O-])c1>>CCOP(=O)(OCC)c1cccc(N)c1,,CCO,,Cl[Sn]Cl,,val
US20070021484A1,CC(C)(C)OC(=O)NC1CCC(C=O)CC1.COc1cc(C(=O)N(C/C(C)=C/c2ccccc2)C[C@@H]2CCCN2)cc2c1OC(C)(C)O2>>COc1cc(C(=O)N(C/C(C)=C/c2ccccc2)C[C@@H]2CCCN2CC2CCC(N)CC2)cc2c1OC(C)(C)O2,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140288140A1,O=[N+]([O-])c1cc(O)cc(C(F)(F)F)c1>>Nc1cc(O)cc(C(F)(F)F)c1,[Ni],CO,,[H][H],,val
US20140329812A1,CC(C)c1ccc(OCc2ccccc2)cc1OCc1ccccc1.O=[N+]([O-])O>>CC(C)c1cc([N+](=O)[O-])c(OCc2ccccc2)cc1OCc1ccccc1,,CC(=O)O,,O=C([O-])O.[Na+],,val
US20100222317A1,C=C1CC(CN)(CC2CC2)C1.O=C(Cl)c1ccc(Cl)cc1Cl>>C=C1CC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)C1,,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20090312309A1,CC(C)N1CCNCC1.COc1ccc(-c2ccc(Cl)nc2)cc1.Cl>>COc1ccc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc1.Cl.Cl,,O,,CS(C)=O,,val
US20030207865A1,Cl.O=S(Cl)Cl.OCC1(NC2CCCC2)CCCC1>>Cl.ClCC1(NC2CCCC2)CCCC1,,CCOCC,Cc1ccccc1,,,val
US20090036492A1,C=Cc1ccc2ccccc2c1Br.CN(C)C=O>>C=Cc1ccc2ccccc2c1C=O,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20030166639A1,Cc1cc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)c(OCC(F)(F)F)cc3NC(=O)OC(C)(C)C)c2)c(C)cn1>>Cc1cc(-c2cccc(C3=Nc4cc(OCC(F)(F)F)c(C(F)(F)F)cc4NC(=O)C3)c2)c(C)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040082619A1,CCCCn1cc2c(c(C#N)c1=O)CCCC2>>CCCCN1CC2=C(CCCC2)C(C#N)C1=O,,Cc1ccccc1,,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US20120077993A1,CC1(C)OC(C)(C)C2(OC2c2cc(-c3ccc(Cl)cc3)ccc2Br)C1=O>>CC1(C)OC(C)(C)C(=O)C(c2cc(-c3ccc(Cl)cc3)ccc2Br)C1=O,,ClCCl,,O=S(=O)(O)O,,val
US05492905,COc1cc(=O)c2ccc(Cl)cc2[nH]c1=O.NCc1ccccc1>>O=c1[nH]c2cc(Cl)ccc2c(=O)cc1NCc1ccccc1,,CO,,,,val
US20040132727A1,COc1cc2nccc(Oc3ccc(N)c(F)c3)c2cc1OC.O=C(N=C=S)c1ccc(Cl)cc1>>COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)c4ccc(Cl)cc4)c(F)c3)c2cc1OC,,Cc1ccccc1,,CCO,,val
US05143920,CCCC(=O)c1cnc2c(OC)cccc2c1Cl.Nc1ccc(O)c(Cl)c1>>CCCC(=O)c1cnc2c(OC)cccc2c1Nc1ccc(O)c(Cl)c1.Cl,,C1COCCO1,,,,val
US20090054609A1,CC(=O)c1cccc(C(C)=Nc2c(C)cc(C)cc2Cl)n1.Cc1cccc(C)c1N>>CC(=Nc1c(C)cccc1C)c1cccc(C(C)=Nc2c(C)cc(C)cc2Cl)n1,,C1CCOC1,,,,val
US20050209230A1,COC(=O)c1cc2cc([N+](=O)[O-])ccc2o1>>c1ccc2occc2c1,[Pd],CO,,O=S(=O)([O-])[O-].[Na+].[Na+],,val
US20050130954A1,CC(C)(C)OC(=O)N1CCNCC1.O=C1Cc2c(Cl)ncnc2N1>>CC(C)(C)OC(=O)N1CCN(c2ncc3c(n2)NC(=O)C3)CC1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20160002169A1,CC(C)(C)OC(=O)C[C@@H]1C[C@@H](C(=O)O)C1.COc1ccc2c(c1)CCN[C@H]2C(=O)Nc1ccc([Si](C)(C)C)c(F)c1>>COc1ccc2c(c1)CCN(C(=O)[C@@H]1C[C@@H](CC(=O)OC(C)(C)C)C1)[C@H]2C(=O)Nc1ccc([Si](C)(C)C)c(F)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060270670A1,CN.COC(=O)/C=C/CBr.Cl>>CNC/C=C/C(=O)OC.Cl,,C1CCOC1,CC(C)O,ClCCl,,val
US04808586,CCOC(=O)N1CCNCC1.O=C1C=C(Cl)C(=O)c2nsnc21>>CCOC(=O)N1CCN(C2=C(Cl)C(=O)c3nsnc3C2=O)CC1,,CCO,,,,val
US04405530,C=[N+]=[N-].COC(=O)C(CF)(CC(=O)Cl)N1C(=O)c2ccccc2C1=O>>COC(=O)C(CF)(CC(=O)C=[N+]=[N-])N1C(=O)c2ccccc2C1=O,,CCOCC,,,,val
US05731322,CC(=O)C(=NNc1ccccc1)C(=O)Nc1ccccc1.CCN1CC[C@]2(c3cccc(OC)c3)CC(=O)CC[C@H]2C1>>CCN1CC[C@@]2(c3cccc(OC)c3)Cc3[nH]c(C(=O)Nc4ccccc4)c(C)c3C[C@@H]2C1,[Zn],CC(=O)O,,Cl,,val
US20110311474A1,CCCC[Sn](CCCC)(CCCC)c1ccnc(S(C)(=O)=O)n1.CN1CCNCC1>>CCCC[Sn](CCCC)(CCCC)c1ccnc(N2CCN(C)CC2)n1,,O,,C1COCCO1,,val
US20130158276A1,O=C1CCc2ccccc21>>O[C@@H]1CCc2ccccc21,,CO,,[H][H],,val
US20150045217A1,COC(=O)c1scnc1N.Cc1ccc(-c2ccc(Cl)cc2)cc1CC(=O)Cl>>COC(=O)c1scnc1NC(=O)Cc1cc(-c2ccc(Cl)cc2)ccc1C,,CC#N,,c1ccncc1,,val
US20160228437A1,Clc1ccc2ncc(-c3cc4ccncc4s3)n2n1.N[C@H]1CC[C@H](O)CC1>>O[C@@H]1CC[C@@H](Nc2ccc3ncc(-c4cc5ncccc5s4)n3n2)CC1,,CS(C)=O,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US04687861,N#CC=CN1CCOCC1.O=[N+]([O-])C=Cc1cccc(Cl)c1Cl>>N#CC(=CN1CCOCC1)C(C[N+](=O)[O-])c1cccc(Cl)c1Cl,,ClC(Cl)Cl,,C1CCOC1,,val
US20050171163A1,CC(=O)CS(=O)(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1.O=S(=O)(NF)c1ccccc1>>CC(=O)C(F)S(=O)(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1,,C1CCOC1,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100016330A1,Cc1ccc(C(F)(F)F)cc1S(=O)(=O)N1CCN(C(=O)OC(C)(C)C)[C@@H](C)C1>>Cc1ccc(C(F)(F)F)cc1S(=O)(=O)N1CCN[C@@H](C)C1,,C1COCCO1,,Cl,,val
US20150141413A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.C[C@@]1(c2cc(Br)ccc2F)CS(=O)(=O)C2(CCC2)C(=O)N1>>C[C@@]1(c2cc(Br)ccc2F)CS(=O)(=O)C2(CCC2)C(=S)N1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US06632826B1,CCOC(=O)CC(=O)C(Cc1ccccc1)NC(=O)OC(C)(C)C>>CCOC(=O)CC(O)C(Cc1ccccc1)NC(=O)OC(C)(C)C,,CCO,,[BH4-].[Na+],,val
US20080009530A1,CCCCCCN(C)S(N)(=O)=O.COCCOc1ccc(CCC(=O)O)c(Oc2ncc(C(F)(F)F)cc2Cl)c1>>CCCCCCN(C)S(=O)(=O)NC(=O)CCc1ccc(OCCOC)cc1Oc1ncc(C(F)(F)F)cc1Cl,,C1CCOC1,CCOC(C)=O,C1CCC2=NCCCN2CC1,Cl,val
US06140344,Cc1ccc(C(=O)N[C@H](C=O)C(C)C)cc1.Clc1ccc(C2(C3CCNCC3)OCCO2)cc1Cl>>Cc1ccc(C(=O)NC(CN2CCC(C3(c4ccc(Cl)c(Cl)c4)OCCO3)CC2)C(C)C)cc1,,ClCCl,,,,val
US20100068176A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.COC(=O)c1cccc(N)c1N>>COC(=O)c1cccc2nc([C@@H]3CCCN3C(=O)OC(C)(C)C)[nH]c12,,CC(=O)O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160184305A1,COc1ccc(CO)c(N)c1>>COc1ccc(C=O)c(N)c1,O=[Mn]=O,ClCCl,,,,val
US20080039450A1,COc1cc(C(=O)O)ccc1Nc1cncc(-c2cc3ccccc3n2C(=O)OC(C)(C)C)n1.OCCN1CCNCC1>>COc1cc(C(=O)N2CCN(CCO)CC2)ccc1Nc1cncc(-c2cc3ccccc3[nH]2)n1,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US04714766,ClP(Cl)(Cl)(Cl)Cl.O=c1[nH]c2ccc(Cl)cc2o1>>Clc1ccc2nc(Cl)oc2c1,,Clc1ccccc1Cl,,,,val
US20130059853A1,CCI.COc1ccc(-c2ccc3c(c2)COC3=O)c(OC)c1O>>CCOc1c(OC)ccc(-c2ccc3c(c2)COC3=O)c1OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090221551A1,CC(C)(C)OC(=O)NCCn1c(S(C)(=O)=O)nc2cnc3cccnc3c21>>c1cnc2c(c1)ncc1nc3n(c12)CCN3,,CCO,,C,C[O-].[Na+],val
US20160244436A1,Brc1ccc(COC2COC(c3ccccc3)OC2)cc1>>OCC(CO)OCc1ccc(Br)cc1,,CO,,,,val
US20130040934A1,CN1CCNCC1.FC(F)c1nc2ccccc2n1-c1nc(Cl)nc(N2CC3(COC3)C2)n1>>CN1CCN(c2nc(N3CC4(COC4)C3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080207654A1,CCCCc1nc(C)n(Cc2noc(-c3ccccc3)n2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCCc1nc(C)n(Cc2noc(-c3ccccc3)n2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US06350749B1,CC#CCN.O=C1CC(=O)CC(c2ccc(Cl)s2)C1>>Cc1ccnc2c1C(=O)CC(c1ccc(Cl)s1)C2,,CCN(CC)CC,,C1CCOC1,Cl,val
US20150148311A1,COC(=O)c1cccc(=O)n1Cc1cc(Cl)ccc1Cl>>O=C(O)c1cccc(=O)n1Cc1cc(Cl)ccc1Cl,,C1CCOC1,O,[Li+].[OH-],,val
US20040138195A1,CC(C)(C)OC(=O)N(CC=CCl)c1cc(OCc2ccccc2)c2ncccc2c1I>>CC(C)(C)OC(=O)N1CC(CCl)c2c1cc(OCc1ccccc1)c1ncccc21,,c1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US20090275570A1,BrCCc1ccccc1.CC(C)(C)OC(=O)N1CCC[C@H](N)C1>>CC(C)(C)OC(=O)N1CCC[C@H](NCCc2ccccc2)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110230462A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@H](CC1CC1)C(=O)O>>CC(C)(C)OC(=O)N[C@H](CC1CC1)C(=O)O,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20160235716A1,C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)CN1C(=O)N[C@]2(CCc3cc(NC(=O)[C@@H](C)NC(=O)OC(C)(C)C)ccc32)C1=O>>C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)CN1C(=O)N[C@]2(CCc3cc(NC(=O)[C@@H](C)N)ccc32)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080269170A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN1CCC(NCCN2CCCC2)CC1>>CN1CCC(N(CCN2CCCC2)C(=O)OC(C)(C)C)CC1,,ClCCl,,,,val
US20050256159A1,CC(C)(C)OC(=O)OC(=O)[O-].O=C(c1ccc(F)cc1)C1CCNCC1>>CC(C)(C)OC(=O)N1CCC(C(=O)c2ccc(F)cc2)CC1,,ClCCl,,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US20160060229A1,CC(C)(C)OC(=O)N(O)C1(Cc2cccs2)C(=O)NC(=O)NC1=O>>O=C1NC(=O)C(Cc2cccs2)(NO)C(=O)N1,,CCO,Cl,,,val
US20130158051A1,CCCOc1nc(SC)nc2oc(-c3cc(C)c(OCC(=O)OC(C)(C)C)c(C)c3)nc12.O=C(OO)c1cccc(Cl)c1>>CCCOc1nc(S(C)(=O)=O)nc2oc(-c3cc(C)c(OCC(=O)OC(C)(C)C)c(C)c3)nc12,,ClCCl,,[Na+].[OH-],,val
US20110135601A1,Nc1ccc2c(c1)CCCC2=O.[N-]=[N+]=[N-]>>Nc1ccc2c(c1)CCCNC2=O,,Cl,,O=C([O-])[O-].[K+].[K+],,val
US20150252030A1,COC(=O)COc1c(C)cccc1-c1ccoc1.NN>>Cc1cccc(-c2ccoc2)c1OCC(=O)NN,,CCO,,,,val
US06066657,COc1cccc2cc(S(C)(=O)=O)oc12.O=C1CCC(=O)N1Br>>COc1ccc(Br)c2cc(S(C)(=O)=O)oc12,,CC#N,,,,val
US20090306052A1,COc1ccc2c(c1)CC(N1CCCCCC1)C2>>Oc1ccc2c(c1)CC(N1CCCCCC1)C2,,CO,ClCCl,BrB(Br)Br,,val
US06204264B1,CCCCCCCCCCCCCCCCCC(=O)Cl.CNC(=O)c1ccc(NCCN(C)C)c(N)c1>>CCCCCCCCCCCCCCCCCc1nc2cc(C(=O)NC)ccc2n1CCN(C)C,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20130072467A1,O=C1N=C(NCC#CC2CC2)CS1.O=CC1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1>>O=C1N=C(NCC#CC2CC2)/C(=C/C2CCN(Cc3ccc(C(F)(F)F)cc3C(F)(F)F)CC2)S1,,CC(C)O,,C1CC[NH2+]CC1.CC(=O)[O-],,val
US20090054451A1,CCOC(=O)CC1CCN(S(C)(=O)=O)CC1>>CS(=O)(=O)N1CCC(CC(=O)O)CC1,,O,,C1CCOC1,[Li+].[OH-],val
US20160264518A1,COC(=O)/C=C/c1ccccc1N.COCCn1c(Br)nc2ccccc21>>COCCn1c(Nc2ccccc2/C=C/C(=O)OC)nc2ccccc21,Cl,CCO,,,,val
US20050137220A1,CCOC(=O)C[N+](=O)[O-].CCOC(=O)c1[nH]c2ccc(OC)cc2c1CN(C)C>>CCOC(=O)c1[nH]c2ccc(OC)cc2c1CC(C(=O)OCC)[N+](=O)[O-],,Cc1ccccc1C,,,,val
US04931449,C1=NCCc2c1oc1ccccc21.Cl>>Cl.c1ccc2c3c(oc2c1)CNCC3,,CC(C)O,CO,[BH4-].[Na+],,val
US05183820,Nc1cc(F)ccc1F.O=C1CCNC(=O)C1>>O=C1C=C(Nc2cc(F)ccc2F)CCN1,,CCO,,,,val
US20130345212A1,CCOC(=O)COc1ccccc1C.COC(=O)c1cc(I)c(Cl)cc1N>>Cc1ccccc1Oc1c(O)c2cc(I)c(Cl)cc2[nH]c1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20060115425A1,CC(NC(=O)C(C)(C)Oc1ccc(C(F)(F)F)cn1)C(Cc1ccc(O)cc1)c1cc(F)cc(C#N)c1.CI>>COc1ccc(CC(c2cc(F)cc(C#N)c2)C(C)NC(=O)C(C)(C)Oc2ccc(C(F)(F)F)cn2)cc1,,CCOCC,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150344429A1,CCN(CC)S(F)(F)F.N#Cc1cc(Cl)c(C2(O)COC2)cn1>>N#Cc1cc(Cl)c(C2(F)COC2)cn1,,ClCCl,,,,val
US05872131,CC(C)(C)OC(=O)N1CCC(OC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1>>Nc1c(Cl)cc(C(=O)OC2CCNCC2)c2c1CCO2,,C1CCOC1,Cl,[NH4+].[OH-],,val
US05716971,C1CCOC1.CC(C)(C)O/N=C(\O)c1cccnc1C(=O)c1cc(Br)ccc1O>>CCO/C(=N\OC(C)(C)C)c1cccnc1C(=O)c1cc(Br)ccc1O,,C1CCOC1,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20070149582A1,NC(Cc1ccc(F)cc1)c1ccccc1.O=C=NCCCl>>Fc1ccc(CC(NC2=NCCO2)c2ccccc2)cc1,,C1CCOC1,,,,val
US04481142,O=C(OO)c1cccc(Cl)c1.O=C1CCN=C(c2ccccc2F)c2cc(Cl)ccc21>>O=C1CC[N+]([O-])=C(c2ccccc2F)c2cc(Cl)ccc21,,ClCCl,,,,val
US06174901B1,CC(=O)OC(C)=O.Cc1cccc(C2(O)CC(=O)C=C2c2ccncc2)c1.Cc1cccc(C2=CC(=O)CC2(O)c2ccncc2)c1>>CC(=O)OC1(c2cccc(C)c2)CC(=O)C=C1c1ccncc1,,ClCCl,,CN(C)c1ccccn1,,val
US20070155805A1,CCCC(CCOc1ccc(OCC(=O)OCC)c(C)c1)c1sc2cc(C(F)(F)F)ccc2c1C>>CCCC(CCOc1ccc(OCC(=O)O)c(C)c1)c1sc2cc(C(F)(F)F)ccc2c1C,,C1CCOC1,CO,[Na+].[OH-],,val
US20090062251A1,C[NH2+]C1(C(=O)NC2CC2)CC1.Cn1c2c(c3cc(C(=O)O)ccc31)CC(C1CCOCC1)CC2>>CN(C(=O)c1ccc2c(c1)c1c(n2C)CCC(C2CCOCC2)C1)C1(C(=O)NC2CC2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130116235A1,C[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5[C@H]5CC[C@@H]6C5)C4=O)c3C=O)cn(C)c2=O)nc1>>CC1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5[C@H]5CCC6C5)C4=O)c3CO)cn(C)c2=O)nc1,,CO,,[BH4-].[Na+],,val
US05663336,C=CCN(c1ccccc1)c1cc(C(=O)OC)c(C(=O)OC)cc1N(CC=C)c1ccccc1.N>>C=CCN(c1ccccc1)c1cc2c(cc1N(CC=C)c1ccccc1)C(=O)NC2=O,,CO,,,,val
US20070173488A1,CC(C)(C)NS(=O)(=O)COc1ccc(C=O)c(Cl)c1>>NS(=O)(=O)COc1ccc(C=O)c(Cl)c1,,C1COCCO1,O,Cl,,val
US20060100262A1,COC(=O)Cn1c(-c2ccc(F)cc2CN)c(C2CCCCC2)c2ccc(C(=O)OC)cc21>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(=O)NCc1cc(F)ccc1-3,,CCOC(C)=O,CO,C[O-].[Na+],,val
US20100278833A1,C[C@@H](Oc1cc(-n2cnc3cnc(COS(C)(=O)=O)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F.O=C(CN1CCNCC1)N1CCOCC1>>C[C@@H](Oc1cc(-n2cnc3cnc(CN4CCN(CC(=O)N5CCOCC5)CC4)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F,,ClCCl,,,,val
US20110288091A1,CCC(=O)N1CCN(c2ccc(N)cc2C(F)(F)F)CC1.CCOC(=O)c1cnc2ccc(Cl)cc2c1Cl>>CCOC(=O)c1cnc2ccc(Cl)cc2c1Nc1ccc(N2CCN(C(=O)CC)CC2)c(C(F)(F)F)c1,,C1COCCO1,CCOC(C)=O,[Na+].[OH-],,val
US04668669,CN(CCO)C1CCCCC1.O=S(Cl)Cl>>CN(CCCl)C1CCCCC1,,CCOCC,,,,val
US20070049593A1,CS(=O)(=O)Cl.OCCOc1ccccc1OCc1ccccc1>>CS(=O)(=O)OCCOc1ccccc1OCc1ccccc1,,ClC(Cl)Cl,,CCN(CC)CC,[Cl-].[NH4+],val
US20060287343A1,CI.CSSC.Clc1ncnc2ccsc12>>CSc1cc2ncnc(Cl)c2s1,,C1CCOC1,,[Li]CCCC,,val
US20090137595A1,Nc1cn2nc(I)ccc2n1.O=C(O)CC1CC1>>O=C(CC1CC1)Nc1cn2nc(I)ccc2n1,CN(C)C=O,C1CCOC1,CC(=O)N(C)C,O=S(Cl)Cl,O=C([O-])O.[Na+],val
US20090312556A1,COC(=O)c1ccc(C(=O)Cl)cc1.OC(C/N=C/c1ccccc1)COCc1ccccc1>>COC(=O)c1ccc(C(=O)NCC(O)COCc2ccccc2)cc1,,ClC(Cl)Cl,ClCCl,c1ccncc1,,val
US20110207711A1,CCOC(=O)CC1CCN(C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N1CCC(CC=O)C1,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US20090298807A1,CC(C)C(=O)CBr.CCOC(=O)C(N)=S>>CCOC(=O)c1nc(C(C)C)cs1,,CCO,,,,val
US20090221555A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCNc1nnc(-c2ccccc2[N+](=O)[O-])o1>>CC(C)(C)OC(=O)Nc1nnc(-c2ccccc2[N+](=O)[O-])o1,,ClCCl,,CCN(CC)CC,,val
US04843075,O=C1CC2CSc3ccccc3C2=NN1c1ccc(Cl)cc1.OO>>O=C1CC2CS(=O)c3ccccc3C2=NN1c1ccc(Cl)cc1,,CC(=O)O,,O,,val
US20110009444A1,CCC(=O)CBr.Nc1ccc(NC(=O)c2cc3cc(F)ccc3n2Cc2cccc(F)c2)cn1>>CCc1cn2cc(NC(=O)c3cc4cc(F)ccc4n3Cc3cccc(F)c3)ccc2n1,,CC#N,,,,val
US20060148834A1,CCOC(=O)c1cc2cc(Cl)c(O)cc2oc1=O.O=[N+]([O-])O>>CCOC(=O)c1cc2cc(Cl)c(O)c([N+](=O)[O-])c2oc1=O,,O=S(=O)(O)O,,,,val
US20100324068A1,CCOC(=O)C(=O)Cl.COc1cc(C)ccc1Cl>>CCOC(=O)C(=O)c1cc(Cl)c(OC)cc1C,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05849732,CCCCCCCCCCC(C)(C)C(=O)O.COCOc1c(N)cc(OC)cc1C(C)(C)C.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCCCCCCCCCC(C)(C)NC(=O)Nc1cc(OC)cc(C(C)(C)C)c1OCOC,,O,c1ccccc1,CCN(CC)CC,,val
US20030166683A1,CCOC(=O)C(Nc1ccc(C#N)cc1)c1cc(OCC)cc(OC2CCN(C(=O)OC(C)(C)C)CC2)c1F>>CCOC(=O)C(Nc1ccc(C#N)cc1)c1cc(OCC)cc(OC2CCNCC2)c1F,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US05304565,CCCc1nc2ccc(OCCO)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2COC)cc1.O=C(Cl)c1ccccc1>>CCCc1nc2ccc(OCCOC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2COC)cc1,,c1ccncc1,,,,val
US20080114003A1,COCOc1ccccc1CC(=O)O.Nc1onc(-c2ccc(F)cc2)c1-c1ncccn1>>COCOc1ccccc1CC(=O)Nc1onc(-c2ccc(F)cc2)c1-c1ccncn1,,C1CCOC1,,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US04898455,CC=CN1CCCCC1.CCCCCCC[C@@H]1CC[C@@H](C(=O)C=CCl)CC1>>CCCCCCC[C@@H]1CC[C@@H](C(=O)C=CC(C)=CN2CCCCC2)CC1,,CCOCC,,CCN(CC)CC,O,val
US05623072,CN.COc1cnnc(-c2cccc(C(F)(F)F)c2)c1F>>CNc1c(OC)cnnc1-c1cccc(C(F)(F)F)c1,,C1CCOC1,O,,,val
US20060293297A1,CC1CCCC(C)N1.N#CCBr>>CC1CCCC(C)N1CC#N,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20090258852A1,CS(=O)(=O)Cl.O=c1[nH]ccc2cc(CO)c3ccc(Br)cc3c12>>CS(=O)(=O)OCc1cc2cc[nH]c(=O)c2c2cc(Br)ccc12,,C1CCOC1,CCOCC,CCN(CC)CC,,val
US04337270,COc1ccc(C=CC(=O)Cl)cc1OC.Nc1cc(Cl)ccc1C(=O)O>>COc1ccc(C=CC(=O)Nc2cc(Cl)ccc2C(=O)O)cc1OC,,C1CCOC1,,CCN(CC)CC,,val
US20080206194A1,Nc1ccccc1.O=C(Cl)c1cc([N+](=O)[O-])ccc1Cl>>O=C(Nc1ccccc1)c1cc([N+](=O)[O-])ccc1Cl,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20120134959A1,CC1(C)OB(c2ccc(N)cc2)OC1(C)C.CN(C)Cc1cc(N2C3CCC2COC3)nc(Cl)n1>>CN(C)Cc1cc(N2C3CCC2COC3)nc(-c2ccc(N)cc2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20090312342A1,CCOC(=O)NC[C@@H]1CCCN(c2nc(-c3c(O)cccc3F)nc3cc(C)ccc23)C1.Cl>>CCOC(=O)NC[C@@H]1CCCN(c2nc(-c3c(O)cccc3F)nc3cc(C)ccc23)C1.Cl,,ClCCl,,CCOCC,,val
US20120122942A1,CCCCC=Cc1cc2cc(Cl)ccc2[nH]1>>CCCCCCc1cc2cc(Cl)ccc2[nH]1,[Pd],CCO,,[H][H],,val
US05716936,CC(C)(C)OC(=O)C1CC(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)C(c2ccccc2F)N1C(=O)CNC(=O)Nc1cccc(C(=O)OCc2ccccc2)c1>>CC(C)(C)OC(=O)C1CC(S(=O)(=O)c2ccc(N)cc2)C(c2ccccc2F)N1C(=O)CNC(=O)Nc1cccc(C(=O)O)c1,[Pd],CCO,,,,val
US20150174099A1,CC(CCCc1ccccc1)C(=O)ON1C(=O)CCC1=O.N[C@@H](CO)c1ccccc1>>C[C@@H](CCCc1ccccc1)C(=O)N[C@@H](CO)c1ccccc1,,C1CCOC1,,,,val
US06011028,Cl.Cl.N=C1CCCCC(Cc2ccc(N)cc2)N1>>Cl.Cl.N=C1CCCCC(CC2CCC(N)CC2)N1,[Rh],CCO,,[H][H],,val
US20070179136A1,CC(C)(C)OC(=O)N1CCC(c2ccc(C(=O)Nc3cc(Cl)cc(C(N)=O)c3N)cc2)CC1>>NC(=O)c1cc(Cl)cc2[nH]c(-c3ccc(C4CCNCC4)cc3)nc12,,CC(=O)O,,,,val
US05440044,Brc1cccc(Br)n1.COC(=O)c1cccc(O)c1>>COC(=O)c1cccc(Oc2cccc(Br)n2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05215983,C=CCOC(=O)N1C[C@H](O)C[C@H]1Cn1ccn2nccc12.CS(=O)(=O)Cl>>C=CCOC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1Cn1ccn2nccc12,,CCN(CC)CC,CCOC(C)=O,O,,val
US20160052922A1,CC(C)n1ncc2c(N3CCOCC3)cc(-c3cccc(O)c3)nc21.O=[N+]([O-])c1cccc(S(=O)(=O)OC[C@H]2CO2)c1>>CC(C)n1ncc2c(N3CCOCC3)cc(-c3cccc(OC[C@H]4CO4)c3)nc21,,C1CCOC1,,[H-].[Na+],,val
US20050075342A1,CCOC(=O)CCCCC(C(=O)OC(C)(C)C)C(=O)c1cc(C)on1>>CCOC(=O)CCCCC(C(=O)O)C(=O)c1cc(C)on1,,O=C(O)C(F)(F)F,,,,val
US20060106037A1,CC(O)C(CCCc1ccccc1)n1cnc2c(=O)[nH]c(Cc3ccc(Cl)c(OC(F)F)c3)nc21>>CC(=O)C(CCCc1ccccc1)n1cnc2c(=O)[nH]c(Cc3ccc(Cl)c(OC(F)F)c3)nc21,,ClCCl,,CCN(CC)CC,CS(C)=O,val
US20050176724A1,Cc1ccc2c(OCCN3CCNCC3)cccc2n1.N#Cc1cccc(C=O)c1>>Cc1ccc2c(OCCN3CCN(Cc4cccc(C#N)c4)CC3)cccc2n1,,ClCCCl,,O=C([O-])O.[Na+],,val
US20050026916A1,ClCc1cccc(Br)c1.S=C1N[C@@H](c2ccccc2)[C@@H](c2ccccc2)N1>>Brc1cccc(CSC2=N[C@@H](c3ccccc3)[C@@H](c3ccccc3)N2)c1.Cl,,CCO,,,,val
US20150376120A1,C=CCOC(=O)c1ccc(NC(=O)c2ccc(NC(=O)c3ccc(NC(=O)[C@H](CC#N)NC(=O)c4ccc([N+](=O)[O-])cc4)cc3)c(OC)c2OCC=C)c(OC)c1OCC=C>>C=CCOC(=O)c1ccc(NC(=O)c2ccc(NC(=O)c3ccc(NC(=O)[C@H](CC#N)NC(=O)c4ccc(N)cc4)cc3)c(OC)c2OCC=C)c(OC)c1OCC=C,,CCO,,Cl[Sn]Cl,,val
US20140256719A1,CC(=O)Cl.Nc1cncc(Cl)n1>>CC(=O)Nc1cncc(Cl)n1,,ClCCl,O,,,val
US20070124152A1,CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2[nH]c1=O.CN(C)C=O>>C[C@H](CO)NC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2[nH]c1=O,,CN(C)C=O,,,,val
US20050004187A1,CCc1cn([Si](C)(C)C(C)(C)C)c2ccc(O[Si](C)(C)C(C)(C)C)cc12>>CCc1c[nH]c2ccc(O)cc12,,C1CCOC1,CCOC(C)=O,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20020193382A1,COC(=O)C1(C#N)CCN(C(C)=O)CC1>>COC(=O)C1(CN)CCN(C(C)=O)CC1,[Ni],CO,,N,,val
US20100137194A1,BrC(c1ccccc1)c1ccccc1.C1COCCN1>>c1ccc(C(c2ccccc2)N2CCOCC2)cc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20100249115A1,COc1cc2c(cc1OC)C(c1ccccc1Cl)NCC2.Nc1nc(Cl)c2nc[nH]c2n1>>COc1cc2c(cc1OC)C(c1ccccc1Cl)N(c1nc(N)nc3[nH]cnc13)CC2,,CS(C)=O,O,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20060287381A1,NC[C@H](O)C(=O)O.O=C(OCc1ccccc1)ON1C(=O)CCC1=O>>O=C(C[C@H](O)C(=O)O)OCc1ccccc1,,C1CCOC1,O,O=C([O-])[O-].[K+].[K+],,val
US20090270443A1,CC(C)(C)OC(=O)NN.Cc1cc(O)c([N+](=O)[O-])c(=O)[nH]1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(NNC(=O)OC(C)(C)C)c([N+](=O)[O-])c(OS(=O)(=O)C(F)(F)F)n1,,ClCCl,,CCN(CC)CC,,val
US04550205,COC(=O)C(C)Nc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-].N>>CC(Nc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-])C(N)=O,,CO,,,,val
US20100152160A1,CC(C)(C)OC(=O)N1CC(C(=O)N2CCC(C#N)(Cc3ccc(F)cc3)CC2)Oc2cc(O)c(Cl)cc21>>N#CC1(Cc2ccc(F)cc2)CCN(C(=O)C2CNc3cc(Cl)c(O)cc3O2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05326780,CC(C)[Mg]Cl.COC(=O)[C@H](Cc1ccccc1)NC(C)=O>>CC(=O)NC(Cc1ccccc1)C(=O)C(C)C,,C1CCOC1,,Cl,[Cl-].[NH4+],val
US20140248268A1,CC(C)(C)OC(=O)c1c(NC(=O)NC(=O)c2ccccc2)sc2c1CC(C)(C)OC2>>CC1(C)Cc2c(sc(NC(=O)NC(=O)c3ccccc3)c2C(=O)O)CO1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040248875A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.N#Cc1cnn(CCO)c1N>>N#Cc1cnn(CCOC(c2ccccc2)(c2ccccc2)c2ccccc2)c1N,,c1ccncc1,,,,val
US05556864,COc1cccc(CCc2ccccc2OCC[C@@H]2CCCN2C)c1.Cl>>COc1cccc(CCc2ccccc2OCC[C@@H]2CCCN2C)c1.Cl,,C1COCCO1,,,,val
US06600028B1,CCOC(=O)CC#N.COC1OCCC1Br>>CCOC(=O)C(C#N)C1CCOC1OC,,CN(C)C=O,O,[H-].[Na+],,val
US20070105832A1,CC(C)(C)[Si](C)(C)N1C(=O)C[C@H]1C(=O)O.CI>>C[C@H]1C(=O)N([Si](C)(C)C(C)(C)C)[C@@H]1C(=O)O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20140206661A1,COc1cc(-c2ncc(C)o2)cc(OCc2ccccc2)c1-c1nnc(N(C)C2CC(C)(C)NC(C)(C)C2)s1>>COc1cc(-c2ncc(C)o2)cc(O)c1-c1nnc(N(C)C2CC(C)(C)NC(C)(C)C2)s1,[Pd],CO,,CCOC(C)=O,,val
US20120071489A1,CC(C)(C)c1ccccc1N1CCN(C(=O)c2ccc(O)cc2)CC1.COC(=O)CBr>>COC(=O)COc1ccc(C(=O)N2CCN(c3ccccc3C(C)(C)C)CC2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130245035A1,Cc1c(Cl)ccnc1C(O)C1CC1>>Cc1c(Cl)ccnc1C(=O)C1CC1,O=[Mn]=O,ClCCl,,,,val
US04046907,CCOC(=CC#N)NC.Cc1nc[nH]c1CSCCN>>CNC(=CC#N)NCCSCc1[nH]cnc1C,,c1ccncc1,,,,val
US20140287984A1,CN(C(=O)OC(C)(C)C)C(CCN1C(=O)c2ccccc2C1=O)C(=O)O>>CN(C(=O)OC(C)(C)C)C(CCN)C(=O)O,,CCO,,NN,O,val
US20140315885A1,C1CCNC1.Cc1nc(Cl)ccc1[N+](=O)[O-]>>Cc1nc(N2CCCC2)ccc1[N+](=O)[O-],,O,,O=C([O-])[O-].[K+].[K+],,val
US20110319430A1,CC(=O)Cl.COC(=O)Cc1c(F)cc(F)cc1F>>COC(=O)C(C(C)=O)c1c(F)cc(F)cc1F,,C1CCOC1,,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US06586633B1,CCC(=O)c1cccc(C)c1.O=C1CCC(=O)N1Br>>CCC(=O)c1cccc(CBr)c1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US04251534,Nc1ccccc1O.O=C(C(F)F)C(F)F>>Nc1ccc(C(O)(C(F)F)C(F)F)cc1O,,Cc1ccccc1,,,,val
US06008230,BrC(Br)(Br)Br.O=C(Nc1cccc2cc(CO)cnc12)c1c(Cl)cccc1Cl>>O=C(Nc1cccc2cc(CBr)cnc12)c1c(Cl)cccc1Cl,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090137595A1,Nc1ccc(C(F)(F)F)cc1.O=C(O)c1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1>>O=C(Nc1ccc(C(F)(F)F)cc1)c1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1,CN(C)c1ccncc1,c1ccncc1,,CCN=C=NCCCN(C)C,Cl,val
US20150210682A1,CCOC=C(C(C)=O)C(=O)OCC.COc1cc2c(c(OC)c1)C=NC(C)C2>>CCOC(=O)C1=CN2C(C)Cc3cc(OC)cc(OC)c3C2CC1=O,,CCO,,,,val
US20100292483A1,CCCCCN(C=O)c1cccc(CO/N=C(/c2ccccc2)c2nnnn2C)n1>>CCCCCNc1cccc(CO/N=C(/c2ccccc2)c2nnnn2C)n1,,CCOC(C)=O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20140309193A1,COc1ccc(-n2c(C(=O)N(C)C)c(OC(=O)c3ccc(COP(=O)(OC(C)(C)C)OC(C)(C)C)cc3)c(OC(=O)c3ccc(COP(=O)(OC(C)(C)C)OC(C)(C)C)cc3)c2C(=O)N(C)C)cc1>>COc1ccc(-n2c(C(=O)N(C)C)c(OC(=O)c3ccc(COP(=O)(O)O)cc3)c(OC(=O)c3ccc(COP(=O)(O)O)cc3)c2C(=O)N(C)C)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06153768,COCOc1ccc(C2COc3cc(OCOC)ccc3C2=O)cc1.C[Si](C)(C)Oc1cccc(Br)c1>>COCOc1ccc(C2COc3cc(OCOC)ccc3C2(O)c2ccc(O)cc2)cc1,,C1CCOC1,,[Mg],,val
US04108886,CC(=O)SCCC(=O)NC1(C(=O)O)CCCC1>>O=C(CCS)NC1(C(=O)O)CCCC1,,O,,[NH4+].[OH-],,val
US20110201593A1,CCCS(=O)(=O)Cl.N#CCC(=O)Nc1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1NC1CCNCC1>>CCCS(=O)(=O)N1CCC(Nc2c(NC(=O)CC#N)cnc3c2ccn3S(=O)(=O)c2ccccc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160039783A1,CCOC(=O)C(OC(C)(C)C)c1c(C)sc(/C=C/c2ccccc2)c1C1=CCC(C)(C)CC1>>CCOC(=O)C(OC(C)(C)C)c1c(C)sc(CCc2ccccc2)c1C1=CCC(C)(C)CC1,[Pd],CO,,,,val
US20100272680A1,CC(C)(C)OC(=O)N1CC[C@@H](N)[C@H](O[Si](C)(C)C(C)(C)C)C1.O=C(O)CO>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)CO)[C@H](O[Si](C)(C)C(C)(C)C)C1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05780482,CCOC(=O)c1cnc2ccc(OCC)nc2c1Cl.COc1ccc(N)cc1.Cl>>CCOC(=O)c1cnc2ccc(OCC)nc2c1Nc1ccc(OC)cc1.Cl,,C1CCOC1,CCOCC,O=C([O-])[O-].[K+].[K+],,val
US20060094767A1,CC(C)(C)OC(=O)N1CCC2(CC1)CO2.O=[N+]([O-])c1c[nH]c(Cl)n1>>CC(C)(C)OC(=O)N1CCC(O)(Cn2cc([N+](=O)[O-])nc2Cl)CC1,,CCO,,O=C([O-])O.[Na+],,val
US20150152108A1,Nc1ccnc(Cl)n1.O[C@H]1CCOC1>>Nc1ccnc(O[C@H]2CCOC2)n1,,C1CCOC1,,[H-].[Na+],,val
US04126689,CC(C)N1CCC(Nc2ccc(Cl)cc2)CC1.CCOC(=O)Oc1ccc(CC(=O)Cl)cc1>>CCOC(=O)Oc1ccc(CC(=O)N(c2ccc(Cl)cc2)C2CCN(C(C)C)CC2)cc1,,CC(=O)CC(C)C,,,,val
US05714489,CC(=O)OC(C)=O.Nc1ccc(Cl)cc1N>>CC(=O)Nc1ccc(Cl)cc1NC(C)=O,,Cl,O,CC(=O)[O-].[Na+],,val
US20080255114A1,CC(C)C[C@H](N)CO.CCOC(=O)CCl>>CC(C)C[C@H]1COCC(=O)N1,,Cc1ccccc1,,[H-].[Na+],[Cl-].[NH4+],val
US07642276B2,C[Si](C)(C)CCOCn1nc(S(C)(=O)=O)c2ccc(Br)cc21.Cc1c(F)cc(C(=O)NC2CC2)cc1B1OC(C)(C)C(C)(C)O1>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(S(C)(=O)=O)nn(COCC[Si](C)(C)C)c2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(C)O,,O=C([O-])[O-].[Na+].[Na+],,val
US20100190745A1,CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(B2OC(C)(C)C(C)(C)O2)cn1.COCC(COC)n1cc(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c(=O)c2cc(I)ccc21>>CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2ccc3c(c2)c(=O)c(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)cn3C(COC)COC)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US06013809,CN(C)CC1CSc2ccccc2C1=O.COc1cccc(Br)c1>>COc1cccc(C2(O)c3ccccc3SCC2CN(C)C)c1,,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US05854234,COC1=NC(C(C)(C)C)CCCC1.[Cl-].[NH4+]>>CC(C)(C)C1CCCCC(=N)N1.Cl,,CCO,,,,val
US20060111560A1,CC(=O)O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O>>CC(=O)[O-].CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,,CCOC(C)=O,,,,val
US20040077669A1,Clc1cc(Cl)ncn1.OB(O)c1cccc(F)c1>>Fc1cccc(-c2cc(Cl)ncn2)c1,,O,,COCCOC,,val
US04835284,Cc1cc(-n2nc3cc(Cl)ccc3[n+]2[O-])c(O)c(C(C)(C)C)c1>>Cc1cc(-n2nc3ccc(Cl)cc3n2)c(O)c(C(C)(C)C)c1,,O,,O=S(=O)(O)O,,val
US06214879B1,COC(=O)CCCCCOc1cc(OC)ccc1[N+](=O)[O-]>>COC(=O)CCCCCOc1cc(OC)ccc1N,[Pd],,,,,val
US20140121197A1,Nc1cc(-c2ccccc2)n[nH]1.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1c1cc(-c2ccccc2)n[nH]1,,CC(=O)O,O,,,val
US20020183320A1,COc1ccccc1C=O.Nc1nc(CC(=O)O)cs1.[C-]#[N+]C(C)(C)C>>COc1ccccc1-c1nc2scc(CC(=O)O)n2c1NC(C)(C)C,,[O-][Cl+3]([O-])([O-])O,,,,val
US20120172291A1,O=S(Cl)Cl.Oc1nc2ccccc2nc1-c1cc2ccccc2o1>>Clc1nc2ccccc2nc1-c1cc2ccccc2o1,,Cc1ccccc1,ClCCl,CN(C)C=O,,val
US04426382,C=CCCC(=O)Cl.COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC>>C=CCCC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)cc3n2)CC1,,CCN(CC)CC,,C1CCOC1,Cl,val
US20040138449A1,CNC(CO)Cc1ccccc1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2sc(CCl)cc21>>CN(Cc1cc2c(s1)c(=O)c(C(=O)NCc1ccc(Cl)cc1)cn2C)C(CO)Cc1ccccc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20120178751A1,Cc1ccc(C(=O)CBr)cc1[N+](=O)[O-].Nc1ccc(Cl)nn1>>Cc1ccc(-c2cn3nc(Cl)ccc3n2)cc1[N+](=O)[O-],,CC#N,O,,,val
US20050032871A1,Cc1[nH]c(C=O)c(CCC(=O)O)c1S(C)(=O)=O.O=C1Cc2cc(-c3ccccc3)ccc2N1>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(-c4ccccc4)cc32)c(CCC(=O)O)c1S(C)(=O)=O,,CCO,,C1CCNCC1,,val
US06521643B1,CC(=O)N(C)C.COc1cccnc1C>>COc1cccnc1CC(C)=O,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20090181963A1,O=C([O-])c1cccc(-n2nnc3c(N4CCOCC4)nc(-c4cccc(O)c4)nc32)c1>>O=C(O)c1cccc(-n2nnc3c(N4CCOCC4)nc(-c4cccc(O)c4)nc32)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20160009704A1,C#CC(=O)OC.C#CCCCCN=[N+]=[N-]>>C#CCCCCn1cc(C(=O)OC)nn1,,CC(C)(C)O,O,O=C(CO)O[CH][C@@H](O)CO,C[O-].[Na+],val
US20130079320A1,COc1cc(C(C)C(=O)NCc2ccc(C(F)(F)F)nc2N2CCCC2)ccc1CNC(=O)OC(C)(C)C>>COc1cc(C(C)C(=O)NCc2ccc(C(F)(F)F)nc2N2CCCC2)ccc1CN,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US05866588,CCC[Mg]Cl.Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C=O)n2)cc1>>CCCC(O)/C=C/c1cccc(/C(=C/CN2CCCC2)c2ccc(C)cc2)n1,,C1CCOC1,,,,val
US05164400,CC1(C)CCc2cccc3c(-c4ccc(F)cc4)cn1c23.CN(C)C=CC=O>>CC1(C)CCc2cccc3c(-c4ccc(F)cc4)c(/C=C/C=O)n1c23,,CC#N,O,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US20110319380A1,COC(=O)C1CCCCCC1=O.Nc1cc(Br)ccn1>>O=c1c2c(nc3cc(Br)ccn13)CCCCC2,,ClCCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US20110201592A1,C#CCO.CC(C)(C)OC(=O)N1CC[C@H](Nc2nc(-c3ccccc3O)nc3ccc(Br)cc23)C1>>CC(C)(C)OC(=O)N1CC[C@H](Nc2nc(-c3ccccc3O)nc3ccc(C#CCO)cc23)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,CCN(CC)CC,,val
US20050228003A1,CCC(Br)c1nc2sc(Br)c(Br)c2c(=O)n1Cc1ccccc1.CN(C)CCN>>CCC(NCCN(C)C)c1nc2sc(Br)c(Br)c2c(=O)n1Cc1ccccc1,,CCO,,,,val
US20080045493A1,CCCN1CC(c2ccc(N)cc2)C1.O=S(=O)(Cl)c1ccc(CCCF)cc1>>CCCN1CC(c2ccc(NS(=O)(=O)c3ccc(CCCF)cc3)cc2)C1,,ClCCl,c1ccncc1,,,val
US20120071489A1,CC(C)(C)c1cc(Cl)ccc1N1CCN(C(=O)c2ccc(O)cn2)CC1.COC(=O)CBr>>COC(=O)COc1ccc(C(=O)N2CCN(c3ccc(Cl)cc3C(C)(C)C)CC2)nc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20140142126A1,C=C(C)B1OC(C)(C)C(C)(C)O1.CC(C)(C)OC(=O)N1CC[C@@H](n2c(Br)c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1>>C=C(C)c1c(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc2n1[C@@H]1CCN(C(=O)OC(C)(C)C)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20150266824A1,CC(C)(C)[Si](C)(C)ONC(=O)[C@@H]1CC[C@@H](n2ncc(C(=O)N(CC(=O)c3c(Cl)cncc3Cl)Cc3cc(F)cc(F)c3)c2C(F)(F)F)CC1>>O=C(CN(Cc1cc(F)cc(F)c1)C(=O)c1cnn([C@@H]2CC[C@@H](C(=O)NO)CC2)c1C(F)(F)F)c1c(Cl)cncc1Cl,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04749703,Fc1ccc(N2CCNCC2)cc1.O=C(CCCCl)NC1c2ccccc2CSc2ccccc21>>O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NC1c2ccccc2CSc2ccccc21,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20050165065A1,CN[C@@H]1CCN(C(=O)c2ccccc2)C1.O=C=NC(c1ccccc1)c1ccccc1>>CN(C(=O)NC(c1ccccc1)c1ccccc1)[C@@H]1CCN(Cc2ccccc2)C1,,ClCCl,,,,val
US20150018566A1,COc1cc2c(c(OC)c1OC)CCC(=O)C=C2c1cc(O)c(OC)c(O)c1>>COc1ccc(C2=CC(O)CCc3c2cc(OC)c(OC)c3OC)cc1,,ClC(Cl)(Cl)Cl,,,,val
US20080096861A1,CC(C)(C)OC(=O)N1CCC(CCl)C1.CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21>>CN(Cc1nc2ccccc2n1CC1CCN(C(=O)OC(C)(C)C)C1)C1CCCc2cccnc21,,CCOC(C)=O,CN(C)C=O,[I-].[K+],,val
US06281356B1,COC(=O)C(=O)Cl.COc1ccc2ccn(C)c2c1>>COC(=O)C(=O)c1cn(C)c2cc(OC)ccc12,,CCOCC,,,,val
US20070117854A1,O=S(Cl)Cl.O=[N+]([O-])c1ccn(CO)c1>>O=[N+]([O-])c1ccn(CCl)c1,,ClC(Cl)Cl,,,,val
US20130289020A1,NCC1CC1.O=C(O)c1cccc(Cl)n1>>O=C(NCC1CC1)c1cccc(Cl)n1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20140315881A1,COC(=O)Cc1ccc2oc(-c3cccnc3)cc2c1>>O=C(O)Cc1ccc2oc(-c3cccnc3)cc2c1,,O,,Cl,[Na+].[OH-],val
US20020072597A1,CCI.CO[C@@H]1O[C@H](c2cn[nH]n2)[C@H]2OC(C)(C)O[C@@H]12>>CCn1ncc([C@H]2O[C@@H](OC)[C@@H]3OC(C)(C)O[C@@H]32)n1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05688803,NN.O=C1OC(O)c2c1c(O)nc1ccc(Cl)c(Cl)c21>>O=c1[nH]ncc2c1c(O)nc1ccc(Cl)c(Cl)c12,,CS(C)=O,,CCOC(C)=O,O,val
US20040019098A1,COc1cc(C=O)cc(OC)c1.Nc1ccc2c(c1)CC(=O)N2>>COc1ccc(CNc2ccc3c(c2)CC(=O)N3)c(OC)c1,,CN(C)C=O,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100240635A1,CN(C)C=O.COc1ccc(N)c(S(=O)(=O)O)c1.O=S(Cl)Cl>>COc1ccc(NC=[N+](C)C)c(S(=O)(=O)Cl)c1.[Cl-],,Cc1ccccc1,,,,val
US20140213581A1,C=C[Sn](CCCC)(CCCC)CCCC.N#Cc1ncc(Cl)cc1Br>>C=Cc1cc(Cl)cnc1C#N,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,O,,,val
US20140005213A1,COc1cc2nc(C)ccc2cc1F>>Cc1ccc2cc(F)c(O)cc2n1,,Br,,[NH4+].[OH-],,val
US20130190288A1,C[C@@H](N)c1ccc(Br)cc1.O=S(=O)(Cl)Cc1ccccc1>>C[C@@H](NS(=O)(=O)Cc1ccccc1)c1ccc(Br)cc1,,c1ccncc1,,Cl,O,val
US20100298324A1,NCc1cccc(Cl)c1.O=C(O)c1ccc2c(=O)n(-c3cc(O)ccn3)c(=S)[nH]c2c1>>O=C(NCc1cccc(Cl)c1)c1ccc2c(=O)n(-c3cc(O)ccn3)c(=S)[nH]c2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060211720A1,Cc1nc[nH]c1-c1ccccc1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cc1c(-c2ccccc2)ncn1C(c1ccccc1)(c1ccccc1)c1ccccc1,,CCOC(C)=O,CN(C)C=O,,,val
US20120329818A1,CCOC(=O)C1CCN(C(=O)OC(C)(C)C)CC1.COCCOCCl>>CCOC(=O)C1(COCCOC)CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20040133008A1,CC(C)S.Cc1ccc(C(=O)Nc2ccc(N(C=O)CCc3ccccn3)cc2)c(Cl)n1>>Cc1ccc(C(=O)Nc2ccc(N(C=O)CCc3ccccn3)cc2)c(SC(C)C)n1,,CN(C)C=O,O,CCOC(C)=O,CC(C)(C)[O-].[K+],val
US20130042918A1,CCCCC(CC)CN1C(=O)CC(C)=C(C#N)C1=O.CCCCCCc1cc(C=O)sc1-c1ccc(-c2ccc(-c3sc(-c4ccc(N(c5ccccc5)c5ccccc5)cc4)cc3CCCCCC)s2)s1>>CCCCCCc1cc(C=C2C(=O)N(CC(CC)CCCC)C(=O)C(C#N)=C2C)sc1-c1ccc(-c2ccc(-c3sc(-c4ccc(N(c5ccccc5)c5ccccc5)cc4)cc3CCCCCC)s2)s1,,CO,,ClCCl,c1ccncc1,val
US05082943,CNc1ccccc1CSc1nc2c([nH]1)CCCC2.O=C(OO)c1cccc(Cl)c1>>CNc1ccccc1CS(=O)c1nc2c([nH]1)CCCC2,,ClC(Cl)Cl,,,,val
US04607023,CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N[N+](=O)[O-])NC(=O)[C@H](CC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)OC>>CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N[N+](=O)[O-])NC(=O)[C@@H](N)CC(=O)OCc1ccccc1)C(=O)NCC(=O)OC,,CCOC(C)=O,,Cl,,val
US20060199806A1,COC(=O)c1ccc(-c2ccccc2C)c(OC)c1>>COc1cc(C(=O)O)ccc1-c1ccccc1C,,C1CCOC1,,CO,[Na+].[OH-],val
US20100048537A1,NCc1ccco1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=S(=O)(NCc1ccco1)C(F)(F)F,,ClCCl,,CCN(CC)CC,O,val
US20140179715A1,CN1CCn2c1cc(Cl)nc2=O.Cc1cncn1-c1ccc(CO)cc1F>>Cc1cncn1-c1ccc(COc2cc3n(c(=O)n2)CCN3C)cc1F,,C1CCOC1,,[H-].[Na+],,val
US06498172B1,COC(=O)CCc1cccc(CNCc2ccc(-c3ncccn3)cc2)c1.O=S(=O)(Cl)c1ccc(Cl)cc1>>COC(=O)CCc1cccc(CN(Cc2ccc(-c3ncccn3)cc2)S(=O)(=O)c2ccc(Cl)cc2)c1,,CCN(CC)CC,,,,val
US20090306041A1,CC(C)(C)[SiH2]OC(C)(C)c1c(Br)cccc1-n1ccc2cc(C3CC3)ccc2c1=O.Cn1cc(B2OC(C)(C)C(C)(C)O2)cc(Nc2ccc(C(=O)N3CCOCC3)cn2)c1=O>>Cn1cc(-c2cccc(-n3ccc4cc(C5CC5)ccc4c3=O)c2C(C)(C)O[SiH2]C(C)(C)C)cc(Nc2ccc(C(=O)N3CCOCC3)cn2)c1=O,,C1COCCO1,O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],val
US20150152108A1,Cc1ccc(-c2ccc3c(n2)N[C@H]2CCN3C2)cn1.Nc1cccc2cnccc12.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1ccc(-c2ccc3c(n2)N(C(=O)Nc2cccc4cnccc24)[C@H]2CCN3C2)cn1,,C1CCOC1,,CCN(CC)CC,,val
US06451804B1,CC(C)(C)OC(=O)NC1CCNCC1.O=S(=O)(OCC(F)(F)F)C(Cl)(Cl)Cl>>CC(C)(C)OC(=O)NC1CCN(CC(F)(F)F)CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110294850A1,CC(C)c1ccc(NC(=O)Oc2ccc3c(c2)CCN3Cc2ccccc2)cc1>>CC(C)c1ccc(NC(=O)Oc2ccc3c(c2)CCN3)cc1,[Pd],CC(C)O,,Cl,,val
US20150322002A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1cc(F)c(Br)cc1Cl>>COC(=O)c1cc(F)c(C(=O)OC(C)(C)C)cc1Cl,,C1CCOC1,CCOC(C)=O,CC(C)[Mg]Cl,,val
US20130165464A1,Cc1cnc(F)cc1-n1cc(CO)c(-c2ccccc2Cl)c1>>Cc1cnc(F)cc1-n1cc(C=O)c(-c2ccccc2Cl)c1,,CCOCC,ClCCl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20120263659A1,C1CCC(NC2CCCCC2)CC1.CC1CCCO1.Cc1ccccc1.O=S(Cl)Cl>>COc1ccc(/C=C/C(=O)N(C2CCCCC2)C2CCCCC2)cc1,,O,,CC(C)NC(C)C,,val
US06262124B1,CN(CC/C=C/c1cccc(N)c1)C(=O)c1ccccc1>>CNCC/C=C/c1cccc(N)c1,,CCN(CC)CC,CO,,,val
US20110245236A1,ClC1=Nc2cccnc2Nc2ccccc21.NNC(=O)c1ccc(CO)cc1>>OCc1ccc(-c2nnc3n2-c2cccnc2Nc2ccccc2-3)cc1,,CC(=O)N(C)C,,CCN(CC)CC,,val
US20080096878A1,CC(C)(C)OC(=O)n1c(=O)n(C2CCSCC2)c2ccccc21>>O=c1[nH]c2ccccc2n1C1CCSCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150259366A1,COC(=O)c1cc(N(Cc2ccccc2)C(=O)c2ccc(Oc3ccccc3)cc2)ccc1O>>O=C(O)c1cc(N(Cc2ccccc2)C(=O)c2ccc(Oc3ccccc3)cc2)ccc1O,,CC#N,,,,val
US20080249119A1,CC1(C)OC(C=O)C(COCc2ccccc2)O1.CCOC(=O)C(F)(F)Br>>CCOC(=O)C(F)(F)C(O)C1OC(C)(C)OC1COCc1ccccc1,[Zn],C1CCOC1,CCOCC,Cl,,val
US05563280,COc1ccc2oc(=O)cc(O)c2c1.O=P(Cl)(Cl)Cl>>COc1ccc2oc(=O)cc(Cl)c2c1,,Cc1ccccc1,,CCCCN(CCCC)CCCC,,val
US20150152047A1,COC(=O)CC[C@H]1CCCN(C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N1CCC[C@H](CCC(=O)O)C1,,CO,,[Na+].[OH-],,val
US20080153836A1,COC(=O)c1ccc(CO)cc1NC(C)=O.CS(=O)(=O)Cl>>COC(=O)c1ccc(COS(C)(=O)=O)cc1NC(C)=O,,ClCCl,,CCN(CC)CC,,val
US04666510,CCC(=O)C1=C(O)CC(c2c(C)cc(OCc3ccccc3)cc2C)CC1=O>>CCC(=O)C1=C(O)CC(c2c(C)cc(O)cc2C)CC1=O,[Pd],CCOC(C)=O,,Cl,,val
US20120171199A1,O=C(c1nc2c(N3CCOCC3)nc(Cl)nc2n1C1CCCCO1)C(F)(F)F>>OC(c1nc2c(N3CCOCC3)nc(Cl)nc2n1C1CCCCO1)C(F)(F)F,,CO,,[BH4-].[Na+],,val
US20150005279A1,C=CC(=O)O.NC(=O)c1ccc(-c2cccc(N)c2)c2cc(CCO)[nH]c12>>C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c(CCO)cc23)c1,,c1ccncc1,,CCN=C=NCCCN(C)C,,val
US05571833,CI.Cc1c([N+](=O)[O-])ccc(O)c1Cl>>COc1ccc([N+](=O)[O-])c(C)c1Cl,,CN(C)C=O,,[H-].[Na+],,val
US20110257151A1,COC(=O)c1ccc2c(c1)CC(C)(C)C(c1cccc(C(=O)NC3CCOC3)c1)N2>>CC1(C)Cc2cc(C(=O)O)ccc2NC1c1cccc(C(=O)NC2CCOC2)c1,,CO,,[Na+].[OH-],,val
US20100093711A1,CCOC(=O)c1cncn1C1c2ccccc2NC(=O)C1(C)C>>CC1(C)C(=O)Nc2ccccc2C1n1cncc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130029973A1,COC(=O)c1ccc(/C=C/c2ccc([N+](=O)[O-])cc2)cc1>>COC(=O)c1ccc(CCc2ccc(N)cc2)cc1,[Pd],CN(C)C=O,,C1CCOC1,,val
US05346885,O=C1CCCC2C3C=CC(CC3)C12>>O=C1CCCC2C3CCC(CC3)C12,[Pd],CO,,,,val
US20100204196A1,COc1cc2c(cc1Nc1nc(Nc3ccc(F)c(F)c3C(=O)NC(C)C)c3ccn(S(=O)(=O)c4ccc(C)cc4)c3n1)N(C(=O)CN(C)C)CC2>>COc1cc2c(cc1Nc1nc(Nc3ccc(F)c(F)c3C(=O)NC(C)C)c3ccnc-3[nH]1)N(C(=O)CN(C)C)CC2,,C1COCCO1,CCOC(C)=O,O,[Na+].[OH-],val
US20010051645A1,COc1ccc(Oc2c(Cl)cc(CC3SC(=O)NC3=O)cc2Cl)cc1C(C)C>>CC(C)c1cc(Oc2c(Cl)cc(CC3SC(=O)NC3=O)cc2Cl)ccc1O,,ClCCl,,BrB(Br)Br,,val
US04025614,CC(=O)c1c(O)oc(=O)c(C(C)=O)c1O.Nc1cccc(NS(=O)(=O)c2ccccc2)c1>>CC(=O)C1=C(O)C(=C(C)Nc2cccc(NS(=O)(=O)c3ccccc3)c2)C(=O)OC1=O,[Pd],CCO,,[H][H],,val
US20070043001A1,N#Cc1cnc(-c2ccc(CN3CCC(n4ncc5c(N)ncnc54)CC3)cc2)c(-c2ccccc2)c1.NNC(N)=S>>Nc1nnc(-c2cnc(-c3ccc(CN4CCC(n5ncc6c(N)ncnc65)CC4)cc3)c(-c3ccccc3)c2)s1,,O=C(O)C(F)(F)F,,O=C([O-])O.[Na+],,val
US20140100231A1,CCOC(=O)C(=O)OCC.Fc1ccc([Mg]Br)cc1>>CCOC(=O)C(=O)c1ccc(F)cc1,,C1CCOC1,,,,val
US20050043379A1,CC#N.OCC1CCN(CCOc2ccc(O)cc2)CC1.OCN1CCCCC1.Oc1ccc(OCCBr)cc1>>OCC1CCN(CCOc2ccc(Oc3nc4ccccc4o3)cc2)CC1,,CC#N,ClCCl,CCN(C(C)C)C(C)C,,val
US20060004108A1,O=C1CC(=O)C2CCC1C2.O=C=Nc1cccc(C(F)(F)F)c1>>O=C(Nc1cccc(C(F)(F)F)c1)C1C(=O)C2CCC(C2)C1=O,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20020161041A1,COCOc1ccc(C2CCCC(N)C2)c(OCOC)c1.CS(=O)(=O)Cl>>COCOc1ccc(C2CCCC(NS(C)(=O)=O)C2)c(OCOC)c1,,ClCCl,,CCN(CC)CC,,val
US06479512B1,CC(C)(C)OC(=O)Nc1cccc(O[Si](C)(C)C(C)(C)C)c1.CN(C)C=O>>CC(C)(C)OC(=O)Nc1cc(O[Si](C)(C)C(C)(C)C)ccc1C=O,,CCOCC,,CCCCC,[Li]C(C)(C)C,val
US20040097730A1,CCOC(=O)Cn1ccnc(NCC(F)(F)c2ccccn2)c1=O.O=C1CCC(=O)N1Cl>>CCOC(=O)Cn1c(Cl)cnc(NCC(F)(F)c2ccccn2)c1=O,,ClCCCl,,,,val
US20070149577A1,CCO.Clc1ccc(Cl)nc1>>CCOc1ccc(Cl)cn1,,CCO,,C,C[O-].[Na+],val
US20090018345A1,Cc1cc(Oc2c(F)cc(C(F)(F)F)cc2Cl)nn1C(=O)OC(C)(C)C>>Cc1cc(Oc2c(F)cc(C(F)(F)F)cc2Cl)n[nH]1,,CCOC(C)=O,,,,val
US20140350002A1,Cn1c(=O)n(CC(C)(C)C)c2ccc(CCCCN)nc21.O=C(O)c1ccon1>>Cn1c(=O)n(CC(C)(C)C)c2ccc(CCCCNC(=O)c3ccon3)nc21,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080090856A1,CC(C)c1cc(N)n(-c2ccc3ncsc3c2)n1.O=C(Cl)OCC(Cl)(Cl)Cl>>CC(C)c1cc(NC(=O)OCC(Cl)(Cl)Cl)n(-c2ccc3ncsc3c2)n1,,ClCCl,,c1ccncc1,,val
US20100029687A1,C[C@@H](N)c1cccc2ccccc12.O=C[C@H]1CN(C(=O)C(F)(F)F)CC[C@@H]1c1ccccc1>>C[C@@H](NCC1CN(C(=O)C(F)(F)F)CCC1c1ccccc1)c1cccc2ccccc12,,CC(=O)O,ClCCCl,O=C([O-])O.[Na+],,val
US20050203095A1,CC#CCn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c(=O)n(C)[nH]c(=O)c21.Cc1cc2ccccc2c(CCl)n1>>CC#CCn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c(=O)n(C)n(Cc3nc(C)cc4ccccc34)c(=O)c21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040053942A1,Fc1ccc(-c2nn3ccccc3c2Br)cc1.OB(O)c1ccnc(F)c1>>Fc1ccc(-c2nn3ccccc3c2-c2ccnc(F)c2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20040235810A1,CC#C[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCO[C@H]4CC[C@]5(C)[C@H]6C[C@H](O)[C@]7(C)[C@@H]([C@H](C)CC(C)C(=O)O)CC[C@H]7[C@@H]6[C@H](OCCl)C[C@@H]5C4)cc3)C[C@@]21C.CC(C)(C)OC(=O)NCCCC(=O)O>>CC#C[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCO[C@H]4CC[C@]5(C)[C@H]6C[C@H](O)[C@]7(C)[C@@H]([C@H](C)CC(C)C(=O)O)CC[C@H]7[C@@H]6[C@H](OC(=O)CCCNC(=O)OC(C)(C)C)C[C@@H]5C4)cc3)C[C@@]21C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080085890A1,CN(C)/C=C1/C(=O)NCc2ccccc21.Nc1ccc(-c2c[nH]cn2)cc1>>O=C1NCc2ccccc2/C1=C/Nc1ccc(-c2c[nH]cn2)cc1,,Cc1ccccc1,,,,val
US05576340,COC(=O)c1ccc(OCC(C)NCC(O)c2cccc(Cl)c2)cc1C(=O)OC>>CC(COc1ccc(CO)c(CO)c1)NCC(O)c1cccc(Cl)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040077726A1,BrCc1ccccc1.CCOC(=O)CCCCCS(=O)(=O)Nc1ccccc1>>CCOC(=O)CCCCCS(=O)(=O)N(Cc1ccccc1)c1ccccc1,,COCCOC,,O,[H-].[Na+],val
US20100249230A1,C1CCOC1.CC(=O)OC(C)=O.CN(C)c1ccncc1.C[C@@]1(O)C=C[C@H](O)C1>>CCCCCC.CCOC(C)=O,CN(C)c1ccncc1,C1CCOC1,,,,val
US20100076029A1,CC#N.COCCOCC(C)(C)C(=O)OC>>COCCOCC(C)(C)C(=O)CC#N,,Cc1ccccc1,,Cl,[H-].[Na+],val
US20130150376A1,CN.C[C@H]1C[C@]2(CCN1C(=O)OCc1ccccc1)C(=O)CS(=O)(=O)N2c1cccc(F)c1>>CNC1=CS(=O)(=O)N(c2cccc(F)c2)[C@@]12CCN(C(=O)OCc1ccccc1)[C@@H](C)C2,,CCOC(C)=O,ClCCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05004747,CC(C)C(=O)c1ccccc1C(=O)O.CCOC(=O)C(Br)C(=O)OCC>>CCOC(=O)C1(C(=O)OCC)OC(=O)c2ccccc2C1(O)C(C)C,,CCO,,CC(C)(C)O,CC(C)(C)[O-].[K+],val
US20120245144A1,C=C(OCC)c1cc2c(cc1C)OCCn1cc(-c3nc(C)nn3C(C)C)nc1-2>>CC(=O)c1cc2c(cc1C)OCCn1cc(-c3nc(C)nn3C(C)C)nc1-2,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150225373A1,C#CC(C)(C)c1cc(N)n(-c2ccc(C)cc2)n1.O=C(Nc1ccc(Oc2ccnc(Cl)n2)c2ccccc12)Oc1ccccc1>>C#CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)n(-c2ccc(C)cc2)n1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20130005707A1,CC(=O)O/N=C(\C)c1ccc(Br)cc1O>>Cc1onc2cc(Br)ccc12,,,,CCOC(C)=O,c1ccncc1,val
US05362733,O=C1CSC(=O)N1.O=Cc1cc(O)c(O)c([N+](=O)[O-])c1>>O=C1NC(=O)C(=Cc2cc(O)c(O)c([N+](=O)[O-])c2)S1,,CC(=O)O,,C1CCNCC1,,val
US20080027049A1,CC(C)(C)C(=O)Cl.Nc1ccc2oc3c(c2c1)CCCCCC3>>CC(C)(C)C(=O)Nc1ccc2oc3c(c2c1)CCCCCC3,,c1ccncc1,,,,val
US20070203136A1,Cn1cc(-c2ccc(Cl)nn2)cn1.NNC(=O)C(F)(F)c1ccc2ncccc2c1>>Cn1cc(-c2ccc3nnc(C(F)(F)c4ccc5ncccc5c4)n3n2)cn1,,CCCCO,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20130102584A1,O=C(O)c1ccc2nc(-c3ccccc3)oc2c1.O=C(c1nccs1)N1CCC(C2CNC2)CC1>>O=C(c1ccc2nc(-c3ccccc3)oc2c1)N1CC(C2CCN(C(=O)c3nccs3)CC2)C1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130158009A1,CS(=O)(=O)c1ccc(N[C@H]2CCN(C3CCN(c4cnc(Cl)cn4)CC3)C2=O)c(F)c1.O=C1CCC(=O)N1Cl>>CS(=O)(=O)c1ccc(N[C@H]2CCN(C3CCN(c4ncc(Cl)nc4Cl)CC3)C2=O)c(F)c1,,CC(=O)O,,,,val
US20030153568A1,C#C[Si](C)(C)C.CCNC(=O)Nc1nc2ccc(Br)cc2s1>>CCNC(=O)Nc1nc2ccc(C#C[Si](C)(C)C)cc2s1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,CO,CCN(CC)CC,,val
US05763700,CC(=O)OCC(F)=CC1(c2ccc(OC(F)(F)F)cc2)CC1.Fc1ccc(Br)cc1Oc1ccccc1>>FC(=CC1(c2ccc(OC(F)(F)F)cc2)CC1)Cc1ccc(F)c(Oc2ccccc2)c1,,C1CCOC1,,[Mg],,val
US04277498,CC(C)(O)CC1CCCC1.N#CCN1C(=O)c2ccccc2C1=O.O=C(O)C(F)(F)F>>CC(C)(CC1CCCC1)NC(=O)CN1C(=O)c2ccccc2C1=O,,O=C(O)C(F)(F)F,,O,,val
US04382891,FC(F)(F)C(OS(F)(F)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F.O=[N+]([O-])c1ccc(CO)cc1>>O=[N+]([O-])c1ccc(CF)cc1,,ClCCl,,,,val
US20040014754A1,NCCCCn1cnc2c(N)nc3ccccc3c21.O=C(Cl)OCC1c2ccccc2-c2ccccc21>>Nc1nc2ccccc2c2c1ncn2CCCCNC(=O)OCC1c2ccccc2-c2ccccc21,,ClCCl,,,,val
US20050203091A1,CC(=O)n1ncc2cnc(Oc3ccc(F)cc3F)cc21>>Fc1ccc(Oc2cc3[nH]ncc3cn2)c(F)c1,,Cl,,O=C([O-])O.[Na+],,val
US20120010183A1,CC(C)(C)OC(=O)c1cc(F)c(Oc2cnc(OCC3CC(F)(F)C3)c(Cl)c2)cc1F>>O=C(O)c1cc(F)c(Oc2cnc(OCC3CC(F)(F)C3)c(Cl)c2)cc1F,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20100035865A1,CCOC(=O)C1=C(OS(=O)(=O)C(F)(F)F)CN(Cc2ccccc2)CC1.OB(O)c1ccccc1>>CCOC(=O)C1=C(c2ccccc2)CN(Cc2ccccc2)CC1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20100173901A1,CC1Cc2ccc(Br)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1.CCn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>CCn1cc(-c2ccc3c(c2)CN(c2cc(N4CCN(C)CC4)nc(N)n2)C(C)C3)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,O,C1COCCO1,O=C([O-])O.[Na+],val
US20060270692A1,OCCO.Oc1ncnc2cc(F)ccc12>>OCCOc1ccc2c(O)ncnc2c1,,CC(=O)N(C)C,,[H-].[Na+],,val
US05840892,COC(=O)C(O)C(C)(C)C.COC1=NC(C)=NC(OC)C1=S(=O)=O>>COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060276515A1,O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1ccnc(Br)c1.OB(O)c1ccccc1>>O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1ccnc(-c2ccccc2)c1,,C1CCOC1,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20140142083A1,CC=O.COC(=O)c1cccc(NC2CCC(C)(O)CC2)c1C>>CCN(c1cccc(C(=O)OC)c1C)C1CCC(C)(O)CC1,,CC(Cl)Cl,,CC(=O)O,O=C([O-])O.[Na+],val
US20140249196A1,CC(=O)c1cccc(C(C)C)c1.CC(C)(C)[S@@](N)=O>>C/C(=N\[S@@](=O)C(C)(C)C)c1cccc(C(C)C)c1,CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C,C1CCOC1,,O,,val
US20130136794A1,N#CCCBr.Nc1cccnc1.S=C=S>>N#CCCSC(=S)Nc1cccnc1,,CCOCC,,CCN(CC)CC,,val
US04812573,CCOC(=O)CCCCN1CCc2ccc(S(=O)(=O)Nc3cccc(Cl)c3)cc2C1>>O=C(O)CCCCN1CCc2ccc(S(=O)(=O)Nc3cccc(Cl)c3)cc2C1,,CCO,,Cl,,val
US05068325,ClCC=Cc1cccc2ccccc12.Nc1nc2c(s1)CCNCC2>>Nc1nc2c(s1)CCN(CC=Cc1cccc3ccccc13)CC2,,ClC(Cl)Cl,,CO,,val
US20040058978A1,CC(C)(C)OC(=O)NCC(=O)NCc1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1.Cl>>Cl.NCC(=O)NCc1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1,,ClCCl,,CCOC(C)=O,,val
US20110306591A1,CC(=O)N1CC=C(c2cccnc2F)CC1.O[C@@H]1C[C@H](Nc2nc3ccccc3s2)C1>>CC(=O)N1CC=C(c2cccnc2O[C@@H]2C[C@H](Nc3nc4ccccc4s3)C2)CC1,,CCOC(C)=O,CN(C)C=O,Cl,[H-].[Na+],val
US20060014948A1,COCCOCOC(=O)c1ccc(C)c(OCOCCOC)c1>>COCCOCOc1cc(C=O)ccc1C,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20060287344A1,C[C@H](NC1CCC2(CC1)OCCO2)c1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>C[C@@H](c1ccccc1)N(C(=O)C(F)(F)F)C1CCC2(CC1)OCCO2,,ClCCl,,c1ccncc1,,val
US20150108402A1,CCOc1ccc(-c2ccc(CCO)cc2)c(F)c1F.CS(=O)(=O)Cl>>CCOc1ccc(-c2ccc(CCOS(C)(=O)=O)cc2)c(F)c1F,,ClCCl,,CCN(CC)CC,,val
US20070032478A1,CCO.NN.O=[N+]([O-])c1ccccc1>>NC(=O)Cc1ccc(N)cc1,[Ni],,,,,val
US20030119838A1,CC(C)(C)OC(=O)N1CCNCC1.CC(C)Cn1nc(-c2ccccc2)cc(OS(C)(=O)=O)c1=O.Cc1ccc(-c2nn(CC(C)C)c(=O)c(N3CCN(C(=O)OC(C)(C)C)CC3)c2C)cc1F>>Cc1c(-c2ccccc2)nn(CC(C)C)c(=O)c1N1CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,,,val
US20100197683A1,Br[Mg]C1CC1.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(=O)N(C)OC)CC2)c2ncnn12>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(=O)C3CC3)CC2)c2ncnn12,,C1CCOC1,,Cl,,val
US20150232452A1,CC(C)(C)c1nc(-c2ccnc(N)n2)c(Br)s1.CC1(C)OB(c2cccc(N)c2F)OC1(C)C>>CC(C)(C)c1nc(-c2ccnc(N)n2)c(-c2cccc(N)c2F)s1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,,C1COCCO1,O=C([O-])O.[Na+],val
US20020128269A1,COc1ccc(S(=O)(=O)N2CCNCC2C(=O)NN2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1OC.O=C(Cl)c1ccc(-c2ccccc2)cc1>>COc1ccc(S(=O)(=O)N2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2C(=O)NN2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1OC,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US06255333B1,C[Si](C)(C)C#Cc1c(C(F)(F)F)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N>>C[Si](C)(C)C#Cc1cn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)nc1C(F)(F)F,,C1CCOC1,,CC(C)(C)ON=O,,val
US05049564,COc1cccc2c1[C@H]1CCN(Cc3ccccc3)C[C@H]1C2.Cl>>COc1cccc2c1[C@H]1CCNC[C@H]1C2.Cl,[Pd],CO,,,,val
US04990517,CCOC=C(C(=O)OCC)C(=O)c1c(F)c(F)c(F)c(F)c1F.Nc1ccc(F)cc1F>>CCOC(=O)C(=CNc1ccc(F)cc1F)C(=O)c1c(F)c(F)c(F)c(F)c1F,,CCO,,O,,val
US20060211678A1,O=[N+]([O-])c1cnc(O)c(-c2cncs2)c1>>Nc1cnc(O)c(-c2cncs2)c1,[Pd],CO,,,,val
US05374625,COCCOc1nc(N)nc2c1ncn2[C@@H]1C[C@H](COC(=O)c2ccccc2)[C@@H](COC(=O)c2ccccc2)C[C@H]1O>>Nc1nc2c(ncn2[C@@H]2C[C@H](CO)[C@@H](CO)C[C@H]2O)c(=O)[nH]1,,CO,,Cl,C[O-].[Na+],val
US20080114008A1,COC(OC)N(C)C.N#Cc1cc(I)ccc1N>>CN(C)C=Nc1ccc(I)cc1C#N,,O,,,,val
US20150111891A1,CC(=O)OC(C)=O.Cc1cc2ccccc2c(Cl)c1[C@@H](COC(c1ccccc1)(c1ccccc1)c1ccccc1)OC(C)(C)CO>>CC(=O)OCC(C)(C)O[C@H](COC(c1ccccc1)(c1ccccc1)c1ccccc1)c1c(C)cc2ccccc2c1Cl,CN(C)c1ccncc1,CCOC(C)=O,O,c1ccncc1,O=C([O-])O.[Na+],val
US20150315198A1,Cc1cc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nc(C)c1CNc1ncnc2nn(Cc3ccc(Cn4cc(C(F)(F)F)ccc4=O)cc3)cc12>>Cc1cc(N)nc(C)c1CNc1ncnc2nn(Cc3ccc(Cn4cc(C(F)(F)F)ccc4=O)cc3)cc12,,ClCCl,,Cl,,val
US05532258,COc1ccc(C(C)=O)cc1CCl.O=C1NC(=O)c2ccccc21>>COc1ccc(C(C)=O)cc1CN1C(=O)c2ccccc2C1=O,,CN(C)C=O,,[K],,val
US20100324041A1,O=[N+]([O-])c1c[nH]c2nccc(F)c12.c1ccc(CN2CCNCC2)cc1>>O=[N+]([O-])c1c[nH]c2nccc(N3CCN(Cc4ccccc4)CC3)c12,,CN1CCCC1=O,,O,,val
US04255429,COc1cc2c(N)nc(Cl)nc2c(OC)c1OC.O=C1CC2(CCCC2)CC(=O)N1C1CCNCC1>>COc1cc2c(N)nc(N3CCC(N4C(=O)CC5(CCCC5)CC4=O)CC3)nc2c(OC)c1OC.Cl,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20120178957A1,CC(C)(C)OC(=O)N[C@@H](CC(=O)OCc1ccccc1)C(O)c1cc(F)c(F)cc1F>>CC(C)(C)OC(=O)N[C@@H](CC(=O)OCc1ccccc1)Cc1cc(F)c(F)cc1F,,CO,,CCO,,val
US20130281432A1,CC(=O)Cl.CC(C)(C)c1cc2c(s1)C(=O)N(c1cccc(Br)c1CO)C2>>CC(=O)OCc1c(Br)cccc1N1Cc2cc(C(C)(C)C)sc2C1=O,,ClCCl,,c1ccncc1,,val
US06723483B1,Cc1cc(C)cc(C)c1.O=S(=O)(O)C(F)(F)F.O=S(c1ccccc1)c1ccccc1>>Cc1cc(C)c([S+](c2ccccc2)c2ccccc2)c(C)c1.O=S(=O)([O-])C(F)(F)F,,CCCCCC,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20120149704A1,COC(=O)c1cc(O)cc(Oc2ccc(-c3nnc(C)o3)cc2)c1.COC[C@@H](C)O>>COC[C@H](C)Oc1cc(Oc2ccc(-c3nnc(C)o3)cc2)cc(C(=O)OC)c1,,Cc1ccccc1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090042876A1,C#CCN(CCN(C)C(=O)OC(C)(C)C)S(=O)(=O)c1ccc2[nH]c(=O)c3[nH]ccc3c2c1.CCCC(=O)[O-].Cl>>C#CCN(CCNC)S(=O)(=O)c1ccc2[nH]c(=O)c3[nH]ccc3c2c1.CCCC(=O)O.Cl,,CCOCC,,,,val
US06391904B1,CCOC(=O)C(CCBr)NC(=O)OCc1ccccc1.OCCCc1ccc(O)cc1>>CCOC(=O)[C@H](CCOc1ccc(CCCO)cc1)NC(=O)OCc1ccccc1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090076074A1,COc1cc2nccc(Oc3ccc(CC(=O)O)cc3)c2cc1OC.O=C(Cl)C(=O)Cl>>COc1cc2nccc(Oc3ccc(CC(=O)Cl)cc3)c2cc1OC,,ClC(Cl)Cl,,,,val
US20140018319A1,COC(=O)Nc1cc(Br)c(F)c(Br)c1.COc1ccc(CCl)cc1>>COC(=O)N(Cc1ccc(OC)cc1)c1cc(Br)c(F)c(Br)c1,,CN(C)C=O,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20150329533A1,CC(C)Cc1cc(C=O)nn1-c1ccccc1.NO>>CC(C)Cc1cc(C=NO)nn1-c1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US20080287547A1,CN(CCO[Si](C)(C)C(C)(C)C)C1(C(NC(=O)c2cccc(C(F)(F)F)c2Cl)c2ccccc2)CCCC1>>CN(CCO)C1(C(NC(=O)c2cccc(C(F)(F)F)c2Cl)c2ccccc2)CCCC1,,C1CCOC1,CCCCC,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140275179A1,CCOC(=O)CCc1cc(F)c(O)c(F)c1.Cc1ccc(-c2snc(C)c2CO)c(F)c1>>CCOC(=O)CCc1cc(F)c(OCc2c(C)nsc2-c2ccc(C)cc2F)c(F)c1,,Cc1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US06248740B1,CC(C)c1cc2ncnn2nc1Cl.OCCOCCN1CCN(C(c2ccccc2)c2ccccc2)CC1>>CC(C)c1cc2ncnn2nc1OCCOCCN1CCN(C(c2ccccc2)c2ccccc2)CC1,,C1CCOC1,,[H-].[Na+],,val
US20100130476A1,CC(c1ccc(F)cc1)n1cnc2c(NCCc3ccc(O)cc3)nc(Cl)nc21.CCN1CCNCC1>>CCN1CCN(c2nc(NCCc3ccc(O)cc3)c3ncn(C(C)c4ccc(F)cc4)c3n2)CC1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20040110807A1,CCOC(Cc1ccc(O)c2c1CCCC2)C(=O)OC.Cc1sc(-c2ccccc2)nc1CCO>>CCOC(Cc1ccc(OCCc2nc(-c3ccccc3)sc2C)c2c1CCCC2)C(=O)OC,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070135474A1,CCCOC(OCCC)OCCC.Clc1ccccc1.O=C1CCOCC1>>C=C.CCCOC1CCOCC1,,Clc1ccccc1,,,,val
US05106871,CC(=O)Oc1c(CC=C(C)C)c(O)cc(O)c1C(=O)CCc1ccc(O)cc1>>CC(C)=CCc1c(O)cc(O)c(C(=O)CCc2ccc(O)cc2)c1O,,CO,,Cl,[K+].[OH-],val
US20140162971A1,CC(C)OB1OC(C)(C)C(C)(C)O1.Fc1ccc(OCC2CC2)c(Br)c1>>OB(O)c1cc(F)ccc1OCC1CC1,,C1CCOC1,,[Li]CCCC,,val
US20080176857A1,CC(=O)NCCS.CCc1cc2c(N3CCN(C(=O)c4ccc(-c5ccccc5)cc4)CC3)nc(Cl)nc2s1>>CCc1cc2c(N3CCN(C(=O)c4ccc(-c5ccccc5)cc4)CC3)nc(SCCNC(C)=O)nc2s1,,CN(C)C=O,,,,val
US20140163012A1,Cl.O=c1cc(OCc2ccc(F)cn2)ccn1-c1ccc2c3c(oc2c1)CNCC3>>Cl.O=c1cc(OCc2ccc(F)cn2)ccn1-c1ccc2c3c(oc2c1)CNCC3,,CO,,CCOCC,,val
US20070179311A1,CO.O=[N+]([O-])c1cccc([N+](=O)[O-])c1Cl>>COc1c([N+](=O)[O-])cccc1[N+](=O)[O-],,CO,O,C[O-].[Na+],,val
US06441017B1,CC(C)(C)OC(=O)N1CC[C@H](NCCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)C1.CC(C)[Si](Cl)(C(C)C)C(C)C.O=C=O>>CC(C)[Si](OC(=O)N(CCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)[C@H]1CCN(C(=O)OC(C)(C)C)C1)(C(C)C)C(C)C,,ClCCl,O,CCN(CC)CC,,val
US20150376212A1,O=CC(C=O)c1ccccc1Cl.O=S(Cl)Cl>>O=C/C(=C\Cl)c1ccccc1Cl,,ClCCl,,,,val
US20160122345A1,CCOC(=O)COC[C@H](N)c1ccc(SCC)cc1.CCS(=O)(=O)c1ccc([C@@H](N)COC)cc1.Cl>>CCS(=O)(=O)c1ccc([C@@H](N)COCC(=O)OC)cc1.Cl,,CC#N,,O,,val
US20120142685A1,BrBr.CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccnc(Cl)c3)cc3cnccc23)CC1>>CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccnc(Cl)c3)c(Br)c3cnccc23)CC1,,CCOC(C)=O,ClCCl,,,val
US20110301143A1,CC(C)(C)OC(=O)N1CCN(c2ncc(-c3nn[nH]n3)cn2)CC1.CCOC(=O)CBr>>CCOC(=O)Cn1nnc(-c2cnc(N3CCN(C(=O)OC(C)(C)C)CC3)nc2)n1,,C1CCOC1,,CCN(CC)CC,,val
US06635661B2,BrCCc1ccccc1.CCC(=O)N(c1ccccc1)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1>>CCC(=O)N(c1ccccc1)[C@@H]1CCCN(CCc2ccccc2)C1,,ClCCl,O=C(O)C(F)(F)F,O,O=C([O-])[O-].[K+].[K+],val
US20080188528A1,CCOC(=O)c1cccn(-c2ccc(-c3ccccc3)cc2)c1=O>>O=C(O)c1cccn(-c2ccc(-c3ccccc3)cc2)c1=O,,C1CCOC1,CO,[Na+].[OH-],,val
US20110288097A1,CS(=O)(=O)Cl.C[Si](C)(C)CCOCn1cc(C(=O)NC2CCCNC2)c2nc(C3CC3)cnc21>>C[Si](C)(C)CCOCn1cc(C(=O)NC2CCCN(S(C)(=O)=O)C2)c2nc(C3CC3)cnc21,,ClCCl,,CCN(CC)CC,Cl,val
US20040014796A1,CCOC(=O)C(CCSc1ccccc1)NC(=O)c1ccccc1>>O=C(NC(CCSc1ccccc1)C(=O)O)c1ccccc1,,CO,,[Na+].[OH-],,val
US20110190285A1,CC(C#N)C(=O)c1ccc(Cl)cc1.NN>>Cc1c(-c2ccc(Cl)cc2)n[nH]c1N,,CCO,,,,val
US20040209905A1,COc1cc2nccc(Oc3ccc(N)c(Cl)c3)c2cc1OC.COc1ccccc1N=C=O>>COc1ccccc1NC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1Cl,,ClC(Cl)Cl,,CO,,val
US20080021032A1,CCS(=O)(=O)Cl.CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(Cc3cccc(N)c3)n2)cc1Cl>>CCS(=O)(=O)Nc1cccc(Cn2ccc(NC(=O)[C@H](CC3CCCC3)c3ccc(S(C)(=O)=O)c(Cl)c3)n2)c1,,ClCCl,,CN1CCOCC1,,val
US20130129753A1,CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=S)N[C@@H](Cc1ccccc1)C(=O)OC)OC)N(C)C(=O)[C@@H](N)C(C)C.CN(C(=O)OCC1c2ccccc2-c2ccccc21)C(C)(C)C(=O)O>>CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=S)N[C@@H](Cc1ccccc1)C(=O)OC)OC)N(C)C(=O)[C@@H](NC(=O)C(C)(C)N(C)C(=O)OCC1c2ccccc2-c2ccccc21)C(C)C,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160194284A1,COC(=O)c1ccccc1NC(=O)Nc1cccc(-c2cccc(N3CCCC3)n2)c1>>O=C(Nc1cccc(-c2cccc(N3CCCC3)n2)c1)Nc1ccccc1C(=O)O,,C1CCOC1,CO,[Li+].[OH-],,val
US20020111492A1,CCOC(=O)C1(CCCc2c(F)cnc3ccc(OC)cc23)CCN(CCSc2cccs2)CC1>>COc1ccc2ncc(F)c(CCCC3(C(=O)O)CCN(CCSc4cccs4)CC3)c2c1,,C1COCCO1,,Cl,,val
US20130317004A1,O=S(Cl)Cl.OC[C@@H](O)CN1CCOCC1>>Cl.O=S1OC[C@H](CN2CCOCC2)O1,,ClCCl,,,,val
US20060100262A1,COC(=O)CS(N)(=O)=O.COc1ccc2c(c1)CN(C)CCn1c-2c(C2CCCCC2)c2ccc(C(=O)O)cc21>>COC(=O)CS(=O)(=O)NC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCN(C)Cc1cc(OC)ccc1-3,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20040030137A1,COc1cccc(C(=NO)C2CCN(C(=O)OC(C)(C)C)CC2)c1F>>COc1cccc2c(C3CCN(C(=O)OC(C)(C)C)CC3)noc12,,C1CCOC1,CCOC(C)=O,CC(C)(C)[O-].[K+],,val
US20050245592A1,CCc1ccc(CN=[N+]=[N-])c(C#N)n1>>CCc1ccc2c(n1)C(N)=NC2,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20080188460A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1cc(CN)ccc1-c1ccc(Cl)cc1>>COC(=O)c1cc(CNC(=O)OC(C)(C)C)ccc1-c1ccc(Cl)cc1,,ClCCl,,,,val
US20140194431A1,CC(=O)NC(=N)Cc1ccccc1-c1ccccc1Cl.CO>>CC(=O)O.N=C(N)Cc1ccccc1-c1ccccc1,[Pd],,,,,val
US20050131017A1,COC(=O)N[C@H](C(=O)N[C@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(C)(C)C>>COC(=O)N[C@H](C(=O)N[C@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@@H](N)Cc1ccccc1)C(C)(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160214936A1,CNC(C)C.COc1cccc2c1c1c(n2CCF)CCCC1C(=O)Cl>>COc1cccc2c1c1c(n2CCF)CCC[C@@H]1C(=O)N(C)C(C)C,,ClCCl,,Cl,O,val
US20080032972A1,BrP(Br)Br.CC(O)c1c(F)ccc(F)c1Cl>>CC(Br)c1c(F)ccc(F)c1Cl,,O,,ClCCl,,val
US20080021071A1,Br[Mg]C1CC1.O=Cc1ccc(Br)cn1>>OC(c1ccc(Br)cn1)C1CC1,,C1CCOC1,,,,val
US20070197621A1,CC(C)C(N)C(C)C.COc1cccc(OC)c1C=O>>COc1cccc(OC)c1/C=N/C(C(C)C)C(C)C,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120316337A1,COc1c(C(=O)O)ccc2ccccc12.Cc1ccc(C)c([Mg]Br)c1>>Cc1ccc(C)c(-c2c(C(=O)O)ccc3ccccc23)c1,,C1CCOC1,,Cl,O,val
US04219657,CCOC(=O)C1CCc2c(sc3ccccc23)C1>>CCOC(=O)c1ccc2c(c1)sc1ccccc12,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US06281356B1,COC(=O)C(=O)Cl.Cn1ccc2ccc(N3CCOCC3)cc21>>COC(=O)C(=O)c1cn(C)c2cc(N3CCOCC3)ccc12,,ClCCl,,,,val
US20080312227A1,CC(C)(C)C(=O)Nc1nc2ncc(Br)cc2c(=O)[nH]1.COc1ccc(B(O)O)cc1OC>>COc1ccc(-c2cnc3nc(NC(=O)C(C)(C)C)[nH]c(=O)c3c2)cc1OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20140309225A1,CI.O=[N+]([O-])c1ccc2[nH]nc(F)c2c1>>Cn1nc(F)c2cc([N+](=O)[O-])ccc21,,CCOC(C)=O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20030064987A1,BrCc1ccccc1.NC1CCC(=O)NC1=O>>O=C1CCC(NCc2ccccc2)C(=O)N1,,CCN(CC)CC,,,,val
US20030092740A1,COc1ccc(NCC(=O)O)cc1.O=N[O-]>>COc1ccc(N(CC(=O)O)N=O)cc1,,O,,Cl,,val
US20100048564A1,CNc1nc(Oc2ccc(C)c(F)c2)ccc1NC(=O)COc1cccc(C(=O)OC)c1>>COC(=O)c1cccc(OCc2nc3ccc(Oc4ccc(C)c(F)c4)nc3n2C)c1,,O,,CC(=O)O,,val
US20150266890A1,CC(C)N.O=C(O)c1cccc(S(=O)(=O)Cl)c1>>CC(C)NS(=O)(=O)c1cccc(C(=O)O)c1,,CCOC(C)=O,Cl,,,val
US20160039783A1,CCOC(=O)C(OC(C)(C)C)c1c(C)sc(-c2ccc(F)cc2)c1-c1ccc2c(c1)CCCO2>>Cc1sc(-c2ccc(F)cc2)c(-c2ccc3c(c2)CCCO3)c1C(OC(C)(C)C)C(=O)O,,CO,O,[K+].[OH-],,val
US05962529,CCCCCCCCN.Cc1ccc(S(=O)(=O)Cl)cc1>>CCCCCCCCNS(=O)(=O)c1ccc(C)cc1,,ClCCl,O,,,val
US20010056123A1,CC(C)(C)OC(=O)NCCBr.N#Cc1cccc(O)c1>>CC(C)(C)OC(=O)NCCOc1cccc(C#N)c1,,CCOC(C)=O,CN(C)C=O,[I-].[K+],O=C([O-])O.[Na+],val
US05252747,CCCCCC.CS(C)=O.C[C@@H](CCl)N(CC#N)Cc1ccccc1.[C-]#N>>CC(=O)N[C@H]1C[C@H](C)N(Cc2ccccc2)C1,,CS(C)=O,,O,,val
US20110053936A1,CCO/C=C/c1cnc(Cl)cc1N>>Clc1cc2[nH]ccc2cn1,,CO,,Cl,,val
US04115575,Clc1nccnc1Cl.Sc1ccccc1>>Clc1nccnc1Sc1ccccc1,,CCO,,C[O-].[Na+],,val
US20160060282A1,C[C@@H](N)c1ccccc1.O=C1CCc2ccccc2C1>>C[C@@H](NC1CCc2ccccc2C1)c1ccccc1,,CO,,O=CO,,val
US20040157886A1,Nc1ccc2cn[nH]c2c1.O=C(O)C(=O)N1CCC(Cc2ccc(F)cc2)CC1>>O=C(Nc1ccc2cn[nH]c2c1)C(=O)N1CCC(Cc2ccc(F)cc2)CC1,,CCOCC,,,,val
US05264435,CNc1ccnc(Cl)n1.c1ccc(C2CCNCC2)cc1>>CNc1ccnc(N2CCC(c3ccccc3)CC2)n1,,CCCCO,,,,val
US20090163488A1,Cc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(F)c(NC(=O)c4cc(C)nn4C)c3)cn2)cc1.NC(=O)CI>>Cc1ccc(S(=O)(=O)N=c2ccc(Oc3ccc(F)c(NC(=O)c4cc(C)nn4C)c3)cn2CC(N)=O)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20100239576A1,COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)OC(=O)[C@H](C)N)n(-c5ccccc5)c4=O)cc3F)ccnc2c1.O=C(O)/C=C\C(=O)O>>COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)OC(=O)[C@H](C)N)n(-c5ccccc5)c4=O)cc3F)ccnc2c1.O=C(O)/C=C\C(=O)O,,CCOC(C)=O,,CO,,val
US20160207926A1,CCNc1ncnc(Cl)c1NC(=O)C(C)(C)C>>CCn1c(C(C)(C)C)nc2c(Cl)ncnc21,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110281870A1,CS(=O)(=O)Cl.O[C@H]1CC[C@H]2CN(Cc3ccccc3)C[C@@H]12>>CS(=O)(=O)O[C@H]1CC[C@H]2CN(Cc3ccccc3)C[C@H]21,,ClCCl,,CCN(CC)CC,,val
US20110034526A1,CS(=O)(=O)[O-].Cc1nc2c(C(F)(F)F)cccc2n1-c1cccc(Oc2cccc(S(=O)(=O)CCCI)c2)c1>>Cc1nc2c(C(F)(F)F)cccc2n1-c1cccc(Oc2cccc(S(=O)(=O)CCCS(C)(=O)=O)c2)c1,,CC(=O)N(C)C,,CCOC(C)=O,O,val
US04207234,COC(=O)C(=O)N1CC(NC(=O)COc2ccccc2)C1=O>>O=C(COc1ccccc1)NC1CNC1=O,,CO,,C[O-].[Na+],,val
US20060135578A1,COc1cc(C=O)ccc1O.Cc1oc(-c2cccc([N+](=O)[O-])c2)nc1CCl>>COc1cc(C=O)ccc1OCc1nc(-c2cccc([N+](=O)[O-])c2)oc1C,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20080045521A1,CC(C)NC(C)C.CCOC(=O)OCC.Cc1ccc2c(n1)N(C(=O)OC(C)(C)C)CCC2C.[Li]CCCC>>CC(C)[N-]C(C)C.CCOC(=O)Cc1ccc2c(n1)N(C(=O)OC(C)(C)C)CCC2C.[Li+],,C1CCOC1,,CCCCCC,,val
US20080318976A1,COC(=O)c1c(F)cccc1-c1cnc(C#N)c(F)c1>>COC(=O)c1c(F)cccc1-c1cnc(CN)c(F)c1,[Ni],CO,N,,,val
US20160190472A1,COC(=O)c1cccnc1Br.OB(O)c1ccccc1>>COC(=O)c1cccnc1-c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20070244131A1,CC(C)(CO)CO.O=C(O)c1ccc(B(O)O)s1>>CC1(C)COB(c2ccc(C(=O)O)s2)OC1,,C1CCOC1,,,,val
US20160222033A1,COC(=O)CC(=O)OC.Cc1cnc(N)s1>>Cc1cn2c(=O)cc(O)nc2s1,,Cc1ccccc1C,,,,val
US05143920,CCCC(=O)c1cnc2c(OC)cccc2c1Cl.Cc1cc(O)cc(C)c1N>>CCCC(=O)c1cnc2c(OC)cccc2c1Nc1c(C)cc(O)cc1C,,C1COCCO1,,,,val
US20100280030A1,COC(=O)c1ccc2oc(=O)n(Cc3ccc4[nH]c(=O)[nH]c4c3)c2c1>>O=C(O)c1ccc2oc(=O)n(Cc3ccc4[nH]c(=O)[nH]c4c3)c2c1,,O,,Cl,,val
US20140114068A1,CC(C)c1ccc2c(c1)OC1(O)c3cccc([N+](=O)[O-])c3C(=O)C21NC(=O)c1ccco1>>CC(C)c1ccc2c(c1)OC1(O)c3cccc(N)c3C(=O)C21NC(=O)c1ccco1,[Fe],CCO,,Cl,O,val
US06107329,COC(=O)C(C)(Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1>>CC(Cc1ccccc1)(NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)O,,C1CCOC1,,[Li+].[OH-],,val
US20110065764A1,CCOC(=O)C(=O)CC(=O)c1ccc(C(F)(F)F)cc1.NO>>CCOC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)on1,,CCO,,Cl,,val
US20110098276A1,CC(C)(C)OC(=O)CBr.Oc1ccc(F)cc1>>CC(C)(C)OC(=O)COc1ccc(F)cc1,,CN(C)C=O,,[Na+].[OH-],,val
US20090298815A1,CC(C)c1nc(-c2cccc(NS(=O)(=O)c3cccc(F)c3)c2)c(-c2ccnc(Cl)n2)s1.NC1CC1>>CC(C)c1nc(-c2cccc(NS(=O)(=O)c3cccc(F)c3)c2)c(-c2ccnc(NC3CC3)n2)s1,,CCCCO,,O=C([O-])[O-].[K+].[K+],,val
US20130210800A1,Cc1cncc(C)c1.O=C(OO)c1cccc(Cl)c1>>Cc1cc(C)c[n+]([O-])c1,,ClC(Cl)Cl,,CCOC(C)=O,,val
US20050245741A1,CC(=O)OC(C)=O.Nc1ccc(Cl)cc1O>>CC(=O)Nc1ccc(Cl)cc1O,,CO,,,,val
US20100197675A1,O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O[C@H](CNCC12CC3CC(CC(C3)C1)C2)c1ccccc1>>O=C1O[C@@H](c2ccccc2)CN1CC12CC3CC(CC(C3)C1)C2,,ClCCl,,CCN(CC)CC,,val
US04914093,COc1ccc(C=O)cc1.NNC(=O)COc1ccc(C2=NNC(=O)CC2)cc1Cl>>COc1ccc(C=NNC(=O)COc2ccc(C3=NNC(=O)CC3)cc2Cl)cc1,,CN(C)C=O,,,,val
US04602027,CCOC(=O)C(N)C(C)=O.O=C(Cl)C=Cc1ccccc1>>CCOC(=O)C(NC(=O)C=Cc1ccccc1)C(C)=O,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US06048893,ClCc1ccc2c(c1)OCO2.N#Cc1ccc(O)cc1F>>N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080051395A1,C#C[Si](C)(C)C.COc1ccc(Br)cc1NC(=O)C(F)(F)F>>COc1ccc(C#C[Si](C)(C)C)cc1NC(=O)C(F)(F)F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,,,val
US20030013875A1,O=S(=O)(Cl)c1ccc(Br)cc1.OCCOCc1ccccc1>>O=S(=O)(OCCOCc1ccccc1)c1ccc(Br)cc1,,ClCCl,,CCN(CC)CC,O,val
US20090163524A1,CC(C)(C)OC(=O)NC(CC#N)c1ccc(Cl)cc1>>CC(C)(C)OC(=O)NC(CCN)c1ccc(Cl)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04454138,CC(=O)CBr.CCCCn1c(=S)c2[nH]cnc2n(CC)c1=O>>CCCCn1c(=S)c2c(ncn2CC(C)=O)n(CC)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06887896B1,CCOC(=O)/C=C(C)/C=C/C(F)=C(/C)c1cc2c(c(Br)c1OCC)C(C)(C)CC=C2C(C)(C)C>>CCOc1c(/C(C)=C(F)\C=C\C(C)=C\C(=O)O)cc2c(c1Br)C(C)(C)CC=C2C(C)(C)C,,CCO,,[Na+].[OH-],,val
US20010056203A1,O=C(OCc1ccccc1)c1ccc(Oc2c(F)c(Oc3ccc([N+](=O)[O-])c(OCc4ccccc4)c3)c(F)c(F)c2C(F)(F)F)cc1>>Nc1ccc(Oc2c(F)c(F)c(C(F)(F)F)c(Oc3ccc(C(=O)O)cc3)c2F)cc1O,[Pd],C1CCOC1,CCOC(C)=O,[H][H],,val
US05559230,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3Cl)cc2)c2ccccc21>>CC(C)(C)OC(=O)NC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3Cl)cc2)c2ccccc21,,ClCCl,,CCN(CC)CC,,val
US20100267688A1,N#CC(C#N)C1CCC2(CC1)OCCO2.NO>>N=C1NOC(=N)C1C1CCC2(CC1)OCCO2,,c1ccncc1,,Cl,,val
US20030191133A1,CC(=O)OCCCl.O=C1CCc2ccccc2N1>>CC(=O)OCCN1C(=O)CCc2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20090105219A1,CC12CNc3cccc(c31)NC(=O)C2.O=C1CCC(=O)N1Br>>CC12CNc3ccc(Br)c(c31)NC(=O)C2,,ClCCl,,,,val
US20080249091A1,CCOC(=O)c1c(N(C(C)=O)C(=O)OC(C)(C)C)c2cc(Oc3ccc(OC(F)(F)F)cc3)ccc2n1-c1ccc(OC(C)C)cc1>>CCOC(=O)c1c(NC(C)=O)c2cc(Oc3ccc(OC(F)(F)F)cc3)ccc2n1-c1ccc(OC(C)C)cc1,,ClCCl,,Cl,,val
US06806285B1,C1COCCO1.CC(N)Cc1c[nH]c2ccc(O)cc12.O=C(Cl)OCC1c2ccccc2-c2ccccc21>>CCC(=O)Oc1ccc2[nH]cc(CC(C)N)c2c1,,C1COCCO1,,O,O=C([O-])O.[Na+],val
US20060074119A1,COC(=O)c1sc(-n2cnc3ccccc32)cc1C#Cc1ccccc1>>COC(=O)c1sc(-n2cnc3ccccc32)cc1CCc1ccccc1,[Pd],CCOC(C)=O,,[H][H],,val
US06169107A,CCOC(=O)c1cc2cccc(NCCc3ccccc3)c2n1C.Cl.N=C(N)N>>CNC(N)=NC(=O)c1cc2cccc(NCCc3ccccc3)c2[nH]1.Cl,,CO,,C[O-].[Na+],,val
US20120053173A1,CCOC(=O)CCNC(=O)c1ccc(NC(c2oc3ccc(F)cc3c2C)C2CCCC2)cc1>>Cc1c(C(Nc2ccc(C(=O)NCCC(=O)O)cc2)C2CCCC2)oc2ccc(F)cc12,,C1CCOC1,CCO,[Na+].[OH-],,val
US20040122057A1,CC(C)I.COC(C(=O)NCc1ccc(C#N)cc1)c1c(F)ccc(N)c1F>>COC(C(=O)NCc1ccc(C#N)cc1)c1c(F)ccc(NC(C)C)c1F,,C1CCOC1,O,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20030199479A1,C[C@@H]1NC(=N[N+](=O)[O-])O[C@H]1c1ccc(Cl)cc1.ClCc1ccc(Cl)nc1>>C[C@H]1[C@H](c2ccc(Cl)cc2)OC(=N[N+](=O)[O-])N1Cc1ccc(Cl)nc1,,CN(C)C=O,,[H-].[Na+],,val
US20020028841A1,CC(C)O.NC(=O)c1cc2c(s1)NC(=O)C2.O=Cc1ccc[nH]1>>COc1cc[nH]c1/C=C1\C(=O)Nc2sc(C(N)=O)cc21,,CC(C)O,,C1CCNCC1,,val
US20110263556A1,O=C(NCO)C(F)(F)F.O=C(O)c1c(Cl)cccc1Cl>>O=C(O)c1c(Cl)ccc(CNC(=O)C(F)(F)F)c1Cl,,O,,O=S(=O)(O)O,,val
US20070225363A1,C1CCNCC1.CCCC(CCNC(=O)CC#N)NC(=O)CC#N.CCO.O=Cc1ccc(O)c(O)c1>>CCCC(CCNC(=O)C(C#N)=Cc1ccc(O)c(O)c1)NC(=O)C(C#N)=Cc1ccc(O)c(O)c1,C1CCNCC1,CCO,,,,val
US20150329529A1,Cc1c(C(=O)O)noc1/C=C/C(C)(C)C.Cc1c(N)c(=O)n(C2CCCCC2)n1C>>Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1/C=C/C(C)(C)C,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130317221A1,Cc1cc(C#Cc2ccccc2)ccc1-n1c(C)nc2ccccc2c1=O.O=Cc1ccc(O)cc1>>Cc1cc(C#Cc2ccccc2)ccc1-n1c(/C=C/c2ccc(O)cc2)nc2ccccc2c1=O,,CC(=O)O,,,,val
US20040072829A1,CC#N.CCN(C(C)C)C(C)C.CN(C)C=O.CN1CCNCC1.Clc1nc(Cl)nc(SCCCc2ccccc2)n1>>CN1CCN(c2nc(NC3CCc4cc(O)ccc4C3)nc(SCCCc3ccccc3)n2)CC1,,CC#N,,,,val
US20090169483A1,COc1cc(C2OCCO2)cc(OCCOCCOCCOCCNC(=O)OC(C)(C)C)c1OC>>COc1cc(C=O)cc(OCCOCCOCCOCCNC(=O)OC(C)(C)C)c1OC,,CC(C)=O,,II,,val
US20100261755A1,CCOC(=O)CC(=O)[C@H]1CCN(C(=O)OC)[C@@H](Cc2cccc(F)c2)C1.NO>>COC(=O)N1CC[C@H](c2cc(=O)[nH]o2)C[C@@H]1Cc1cccc(F)c1,,CO,O,Cl,[Na+].[OH-],val
US20080021032A1,CS(=O)(=O)Cn1ccc(N)n1.Cn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)n1>>CS(=O)(=O)Cn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)n1,,ClCCl,,Cc1cccc(C)n1,O=C(Cl)C(=O)Cl,val
US20140018343A1,CCOC(=O)C1CCc2sc3ncnc(O)c3c2C1>>CCOC(=O)c1ccc2sc3ncnc(O)c3c2c1,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20140248240A1,CC(C)(C)OC(=O)N1CCC(CCCN)CC1.O=C(O)c1cc2cnccc2[nH]1>>CC(C)(C)OC(=O)N1CCC(CCCNC(=O)c2cc3cnccc3[nH]2)CC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120232051A1,CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1Br.OB(O)c1ccccc1F>>CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1-c1ccccc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,O=C([O-])[O-].[K+].[K+],,val
US20040138249A1,CCOC(=O)c1c(-c2cccc([N+](=O)[O-])c2)c(C)n2c1-c1cc(OC)c(OC)cc1CC2>>CCOC(=O)c1c(-c2cccc(N)c2)c(C)n2c1-c1cc(OC)c(OC)cc1CC2,[Pd],CO,,,,val
US20080300308A1,CC(C)(C)c1ccc(-c2ccc([N+](=O)[O-])cc2)cc1>>CC(C)(C)c1ccc(-c2ccc(N)cc2)cc1,[Pd],CCO,,,,val
US20020183540A1,COc1cccc(OC)c1C(O)c1c(OC)cccc1OC.COc1cccc(OC)c1Cc1c(OC)cccc1OC>>COc1cccc(OC)c1C(c1c(OC)cccc1OC)C(c1c(OC)cccc1OC)c1c(OC)cccc1OC,,CC#N,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04752322,CC1Cc2cccc(S(=O)(=O)NC(C)(C)C)c2S1.C[Si](C)(C)Cl>>CC1Cc2ccc([Si](C)(C)C)c(S(=O)(=O)NC(C)(C)C)c2S1,,C1CCOC1,CCCCCC,Cl,[Li]CCCC,val
US20090253767A1,CCOc1c([N+](=O)[O-])cc2c(NC(=O)OC(C)(C)C)nn(C(=O)OC(C)(C)C)c2c1F>>CCOc1c(N)cc2c(NC(=O)OC(C)(C)C)nn(C(=O)OC(C)(C)C)c2c1F,[Ni],CO,,[H][H],,val
US04369312,CON=C1C(=O)N2C(C(=O)OCC(Cl)(Cl)Cl)=C(C)CS[C@H]12>>CON[C@@H]1C(=O)N2C(C(=O)OCC(Cl)(Cl)Cl)=C(C)CS[C@H]12,,C1CCOC1,O,Cl,,val
US04407931,CC(=O)C(C#N)=NNc1ccc(S(=O)(=O)O)c2cccnc12.O=P(Cl)(Cl)Cl>>CC(=O)C(C#N)=NNc1ccc(S(=O)(=O)Cl)c2cccnc12,,CN1CCCC1=O,,[K],,val
US05583221,CC(=O)OC(C)=O.CN1C2CCC1C(=NO)C(=O)C2>>CC(=O)NC1C(=O)CC2CCC1N2C,[Ni],,,CC(=O)O,,val
US05559106,COc1ccc(Cn2c(=O)c(=O)[nH]c3ccc4ccccc4c32)c(OC)c1.O=C(Cl)Cl>>COc1ccc(Cn2c(=O)c(Cl)nc3ccc4ccccc4c32)c(OC)c1,,CN(C)C=O,,Cc1ccccc1,,val
US05200111,CC(Cl)CC(C)Oc1ccc(C(=O)O)cc1.N#Cc1ccc(O)cc1>>C[C@H](Cl)C[C@H](C)Oc1ccc(C(=O)Oc2ccc(C#N)cc2)cc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20020156075A1,COc1ccccc1C1CCN(C[C@H](N)CC2CCCCC2)CC1.O=C(Cl)C1CCCCC1>>COc1ccccc1C1CCN(C[C@@H](CC2CCCCC2)NC(=O)C2CCCCC2)CC1,,ClCCl,O,O=C([O-])[O-].[K+].[K+],,val
US04876370,CCOC(=O)CC1(C)OCCO1>>CC1(CCO)OCCO1,,CCOCC,,[H-].[Na+],,val
US20100215618A1,CC(C)(C)OC(=O)N1CCOC[C@H]1c1ncc(-c2ccc(-c3ccc(C(=O)Nc4ccc(CN5CCS(=O)(=O)CC5)cc4)cc3)cc2)[nH]1>>O=C(Nc1ccc(CN2CCS(=O)(=O)CC2)cc1)c1ccc(-c2ccc(-c3cnc([C@@H]4COCCN4)[nH]3)cc2)cc1,,C1COCCO1,,Cl,O=C([O-])[O-].[K+].[K+],val
US20070027155A1,Br.COCc1nc(-c2cccc(Cl)c2)cc(N2CCN(c3ncccc3C(F)(F)F)CC2)n1>>FC(F)(F)c1cccnc1N1CCN(c2cc(-c3cccc(Cl)c3)nc(CBr)n2)CC1,,CC(=O)O,,,,val
US06180844B2,Cc1cc(O)ccc1N.Cc1ccc(C(=O)Cl)cc1>>Cc1ccc(C(N)=O)c(-c2ccc(O)cc2C)c1,,CCN(CC)CC,,CN(C)C=O,,val
US20010051620A1,COc1cc2c(cc1OCc1ccccc1)C(C#N)C2.c1ccc(SSc2ccccc2)cc1>>COc1cc2c(cc1OCc1ccccc1)C(C#N)(Sc1ccccc1)C2,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20140045872A1,CCOC(=O)NCCc1ccc(Cl)c(F)c1>>O=C1NCCc2ccc(Cl)c(F)c21,,O=P(Cl)(Cl)Cl,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20120130078A1,O=C(O)c1n[nH]c2ccccc12.O=[N+]([O-])O>>O=C(O)c1n[nH]c2ccc([N+](=O)[O-])cc12,,O=S(=O)(O)O,,O,,val
US20090042890A1,CCOC(=O)c1nc(Nc2ccccc2CO[Si](C)(C)C(C)(C)C)nc2c1[nH]c(=O)n2-c1ccccc1OC.COc1ccccc1-n1c(=O)[nH]c2c(C(N)=O)nc(Nc3ccccc3CO[Si](C)(C)C(C)(C)C)nc21>>COc1ccccc1-n1c(=O)[nH]c2c(C(N)=O)nc(Nc3ccccc3CO)nc21,,CO,N,,,val
US20040259884A1,CCOc1cc(C(F)(F)F)ccc1C1=NC(c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)N1C(=O)N1CCN(CCC#N)CC1.O=C(Cl)CCl>>CCOc1cc(C(F)(F)F)ccc1C1=NC(c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)N1C(=O)N1CCN(C(=O)CCl)CC1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20100029710A1,CCc1nc2c(C)cc(CCO)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnnn3C(c3ccccc3)(c3ccccc3)c3ccccc3)ccc21>>CCc1nc2c(C)cc(CCO)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21,,CO,,,,val
US20130289033A1,N#Cc1ccc(B(O)O)cc1.O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(I)cc1>>N#Cc1ccc(-c2ccc(C(=O)NCCc3c[nH]c4ccc(Cl)cc34)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20030225082A1,COC[C@H](C)N.Cn1c(=O)c(-c2ccc(F)cc2)c(-c2ccnc(S(C)(=O)=O)n2)n1C1CCN(C(=O)OC(C)(C)C)CC1>>COC[C@H](C)Nc1nccc(-c2c(-c3ccc(F)cc3)c(=O)n(C)n2C2CCN(C(=O)OC(C)(C)C)CC2)n1,,Cc1ccccc1,,,,val
US20050065178A1,CN1CC2CN(c3cc(-c4ccccc4)no3)CC2C1.O=C(O)/C=C/C(=O)O>>CN1CC2CN(c3cc(-c4ccccc4)no3)CC2C1.O=C(O)/C=C/C(=O)O,,CCOCC,CO,,,val
US20050054819A1,Cl[Mg]Cc1ccccc1.O=C1CCC1>>OC1(Cc2ccccc2)CCC1,,C1CCOC1,CCOCC,,,val
US04268264,CC(=O)Nc1ccc(NCCNS(C)(=O)=O)cc1.OCCBr>>CC(=O)Nc1ccc(N(CCO)CCNS(C)(=O)=O)cc1,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20140145119A1,CCCCC(CC)COc1c2cc([Si](C)(C)C)[se]c2c(OCC(CC)CCCC)c2cc([Si](C)(C)C)[se]c12>>CCCCC(CC)COc1c2cc[se]c2c(OCC(CC)CCCC)c2cc[se]c12,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US04855292,Cc1ccc(S(=O)(=O)Cl)cc1.OCCc1c(F)ccc(F)c1F>>Cc1ccc(S(=O)(=O)OCCc2c(F)ccc(F)c2F)cc1,,ClCCl,,CCN(CC)CC,O,val
US20100137308A1,N.O=S1(=O)CCC(S(=O)(=O)Cl)C1>>NS(=O)(=O)C1CCS(=O)(=O)C1,,C1COCCO1,CO,,,val
US20120295924A1,CCN=C=NCCCN(C)C.Cc1scc2c1c(=O)n(C)c(=O)n2C.Nc1nc(-c2ccc(F)c(C(F)(F)F)c2)cs1.On1nnc2ccccc21>>Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(C(F)(F)F)c4)cs3)csc2n(C)c1=O,CN(C)c1ccncc1,ClCCCl,,Cl,,val
US20110275611A1,CC[C@@H]1CCCN1c1cc(-c2ccc(C#N)c(F)c2)nc(N)n1.NN>>CC[C@@H]1CCCN1c1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1,,CCO,,CCOC(C)=O,O,val
US20130129677A1,CC(C)(C)OC(=O)CN(C(=O)CCl)c1cccc(C(F)(F)F)c1>>O=C(O)CN(C(=O)CCl)c1cccc(C(F)(F)F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070060523A1,Cn1cc(NC=O)cc1C(=O)O.O=S(Cl)Cl>>Cn1cc(NC=O)cc1C(=O)Cl,,c1ccccc1,,,,val
US20100041891A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1cccc2c(F)c(Cc3cccc(C(F)(F)F)c3)sc12>>O=S(=O)(Oc1cccc2c(F)c(Cc3cccc(C(F)(F)F)c3)sc12)C(F)(F)F,,c1ccncc1,,Cl,,val
US20100305123A1,CN1CCN(Cc2cccc(C(=O)/C=C/c3cccc(/C=C/C(=O)OC(C)(C)C)n3)c2)CC1.NOC1CCCCO1>>CN1CCN(Cc2cccc(C(=O)/C=C/c3cccc(/C=C/C(=O)NO)n3)c2)CC1,,ClCCl,O=C(O)C(F)(F)F,ClCCCl,On1nnc2ccccc21,val
US20040049051A1,CC1=CC[C@@H](/C(C)=C/c2coc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1.Cc1nc(/C=C/[C@@H]2C[C@@H]3O[C@@H]3CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O2)cs1>>C/C(=C\c1csc(C)n1)[C@@H]1CC=CCCCC[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,,CO,,[Br-].[K+],,val
US20130244993A1,CN1CCN(c2ncc(Br)cn2)C1=O.C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O>>C[C@@H](c1ccc(-c2cnc(N3CCN(C)C3=O)nc2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],val
US20090233919A1,COC(CBr)OC.COc1cc([N+](=O)[O-])ccc1O>>COc1cc([N+](=O)[O-])ccc1OCC(OC)OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070149612A1,O=Cc1ccccc1O.c1ccc2c(c1)CCCO2>>C1=CCCCC=C1.C1CCC2OC2CC1,,CN(C)C=O,,,,val
US20100144787A1,CCc1nc2c(F)ccc(OCC(=O)OC)c2c(OC(F)F)c1Cc1ccc(NC(=O)OC(C)(C)C)cc1>>CCc1nc2c(F)ccc(OCC(=O)OC)c2c(OC(F)F)c1Cc1ccc(N)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090105250A1,Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N.Cc1nc(Cl)cc(Nc2ncc(C(=O)O)s2)n1>>Cc1nc(Cl)cc(Nc2ncc(C(=O)Nc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)s2)n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040110802A1,N#Cc1ccc(/C=C/c2cc(-c3ccccc3)on2)c(C(=O)[O-])c1>>N#Cc1ccc(/C=C/c2cc(-c3ccccc3)on2)c(C(=O)O)c1,,C1CCOC1,COC(C)(C)C,[Na+].[OH-],,val
US20150284408A1,CC(C)(C)OC(=O)N1CCC(NCc2ccc([N+](=O)[O-])o2)CC1>>O=[N+]([O-])c1ccc(CNC2CCNCC2)o1,,C1COCCO1,ClCCl,Cl,,val
US20070066639A1,NCCOCCO.O=[N+]([O-])c1cnc2ccccc2c1Cl>>O=[N+]([O-])c1cnc2ccccc2c1NCCOCCO,,CN(C)C=O,ClCCl,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20010021714A1,Cc1cc(N)on1.O=S(=O)(Cl)c1ccc(Br)cc1>>Cc1cc(NS(=O)(=O)c2ccc(Br)cc2)on1,,c1ccncc1,,,,val
US20070060607A1,CCOC(=O)c1cnc(N)c2c(COc3cccc(COc4ccc(Cl)cc4)c3)csc12.NCCO>>Nc1ncc(C(=O)NCCO)c2scc(COc3cccc(COc4ccc(Cl)cc4)c3)c12,,CS(C)=O,,,,val
US05081130,O=C1CCCN1.O=S(=O)(Cl)c1ccccc1C1CCCCC1>>O=C1CCCN1S(=O)(=O)c1ccccc1C1CCCCC1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20110184015A1,COC(=O)c1cc(Cl)nc2[nH]ccc12>>O=C(O)c1cc(Cl)nc2[nH]ccc12,,CO,,Cl,[Li+].[OH-],val
US20150038590A1,CC(=O)c1cc(F)ccc1C1=CCCC1.NC1CC1>>CC(NC1CC1)c1cc(F)ccc1C1=CCCC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20040204455A1,[N-]=[N+]=NCc1ccc2cccnc2c1>>NCc1ccc2cccnc2c1,[Ni],CO,,,,val
US06107297,CCc1ccc2c(c1)C=Cc1cc(C)ccc1C2c1c[nH]c(=O)[nH]c1=O.COC(=O)CN(C)c1nccc(F)n1>>CCc1ccc2c(c1)C=Cc1cc(C)ccc1C2c1cn(-c2ccnc(N(C)CC(=O)OC)n2)c(=O)[nH]c1=O,,CN1CCCC1=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070099990A1,CC(=O)c1c(C)c(NC=O)c(C)c2c1OCC2c1ccc(C(C)C)cc1>>CC(=O)c1c(C)c(N)c(C)c2c1OCC2c1ccc(C(C)C)cc1,,CO,,Cl,O=C([O-])O.[Na+],val
US20100216746A1,COC(=O)c1[nH]c(C=O)cc1Cl>>O=Cc1cc(Cl)c(C(=O)O)[nH]1,,C1CCOC1,CO,[Li+].[OH-],,val
US05578607,Cc1cc([N+](=O)[O-])c(C)c2c1N=CCC2=O.O=P(Cl)(Cl)Cl>>Cc1cc([N+](=O)[O-])c(C)c2c(Cl)ccnc12,,[NH4+],[OH-],,,val
US20160108000A1,CC(=O)c1cc(F)cc(F)c1.NN=C(c1ccccc1)c1ccccc1>>CC(=NN=C(c1ccccc1)c1ccccc1)c1cc(F)cc(F)c1,,ClCCl,,ClC(Cl)Cl,,val
US20110172203A1,CC(C)(NS(=O)C(C)(C)C)c1ccc(Nc2nc(Cl)ccc2[N+](=O)[O-])cc1.Cl>>CC(C)(N)c1ccc(Nc2nc(Cl)ccc2[N+](=O)[O-])cc1.Cl,,C1COCCO1,ClCCl,CCCCCC,,val
US05856510,CC[Si](C#Cc1ccc2c(c1)c(CCN1CCCC1)cn2S(=O)(=O)c1ccc(C)cc1)(CC)CC>>C#Cc1ccc2[nH]cc(CCN3CCCC3)c2c1,,CO,,[K+].[OH-],,val
US20130197009A1,BrCc1ccccc1.N#Cc1ccc(N2CCNC(=O)C2)cc1Cl>>N#Cc1ccc(N2CCN(Cc3ccccc3)C(=O)C2)cc1Cl,,O,,CN(C)C=O,[H-].[Na+],val
US20100216796A1,COC(=O)c1cccc(-c2cccc(C(=O)NCc3ccccc3)c2)c1.NO>>O=C(NO)c1cccc(-c2cccc(C(=O)NCc3ccccc3)c2)c1,,CN(C)C=O,,CCOC(C)=O,,val
US20150111870A1,COc1nc2c(C)cc(C(O)(c3c(C)nn(C)c3C)c3cnc(C)n3C)cc2c(Cl)c1O.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>COc1nc2c(C)cc(C(O)(c3c(C)nn(C)c3C)c3cnc(C)n3C)cc2c(Cl)c1OCC(F)(F)F,,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100056502A1,CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCNCC1.O=CC1CCn2c(=O)sc3ccc(F)c1c32>>CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCN(CC2CCn3c(=O)sc4ccc(F)c2c43)CC1,,CCOC(C)=O,,,,val
US06096771,CC(C)(C)OC(=O)NCCOc1noc2ccc(F)c(C(N)=O)c12>>CC(C)(C)OC(=O)NCCOc1noc2ccc(F)c(C#N)c12,,CN(C)C=O,,O=P(Cl)(Cl)Cl,,val
US05491144,COC(=O)c1cc(Nc2ccc(F)cc2)c(Nc2ccc(F)cc2)cc1C(=O)OC.N>>O=C1NC(=O)c2cc(Nc3ccc(F)cc3)c(Nc3ccc(F)cc3)cc21,,OCCO,,,,val
US04760140,CC(=O)OCC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](NC(=S)N=CN(C)C)[C@H]2SC1.O=C(CBr)c1ccccc1>>CC(=O)OCC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](Nc3ncc(C(=O)c4ccccc4)s3)[C@H]2SC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150291593A1,Br.CCOC(=O)c1[nH]ccc1N>>CCOC(=O)c1[nH]ccc1Br,,O,,Cl,O=N[O-].[Na+],val
US20080318950A1,BrBr.Nc1cccc(F)c1F>>Nc1ccc(Br)c(F)c1F,,CC(=O)O,,,,val
US20150152048A1,CC(C)(C)OC(=O)c1ccc(N)cc1.CS(=O)(=O)N1CCN([C@H]2C[C@@H](C(=O)O)N(C(=O)OCc3ccccc3)C2)CC1>>CC(C)(C)OC(=O)c1ccc(NC(=O)[C@@H]2C[C@H](N3CCN(S(C)(=O)=O)CC3)CN2C(=O)OCc2ccccc2)cc1,,c1ccncc1,,,,val
US20030191118A1,COC(=O)[C@H](Cc1ccc(OS(=O)(=O)C(F)(F)F)cc1)NC(=O)c1c(Cl)cccc1Cl.N#Cc1cccc(C#N)c1B(O)O>>COC(=O)[C@H](Cc1ccc(-c2c(C#N)cccc2C#N)cc1)NC(=O)c1c(Cl)cccc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US06448236B1,CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4ccc(OC)cc4)nc(CNS(=O)(=O)CC(C)C)nc32)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1>>CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4ccc(OC)cc4)nc(CNS(=O)(=O)CC(C)C)nc32)[C@H](O)[C@@H]1O,,CO,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20030092694A1,BrBr.Clc1nccnc1N1CCNCC1>>Clc1nc(Br)cnc1N1CCNCC1,,CC(=O)O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20130165436A1,COc1ccc2c(c1F)NC(=O)CO2>>O=C1COc2ccc(O)c(F)c2N1,,ClCCl,,BrB(Br)Br,,val
US20140256830A1,COc1cc(OC)cc(C(F)(F)F)c1.O=C1CCC(=O)N1Br>>COc1cc(OC)c(Br)c(C(F)(F)F)c1,,ClCCl,,,,val
US20070135367A1,C[C@H]1CCCCN1.O=[N+]([O-])c1cc(C(F)(F)F)ccc1F>>C[C@H]1CCCCN1c1ccc(C(F)(F)F)cc1[N+](=O)[O-],,O,,CN(C)C=O,,val
US20140088079A1,CC1(C)O[C@@H]2O[C@@H](C(=O)c3ccc(Cl)c(Cc4ccc5c(c4)OCCO5)c3)[C@@H](O)[C@@H]2O1>>CC1(C)O[C@@H]2O[C@@H]([C@@H](O)c3ccc(Cl)c(Cc4ccc5c(c4)OCCO5)c3)[C@@H](O)[C@@H]2O1,,CO,,[BH4-].[Na+],,val
US20140343038A1,CCOC(=O)c1nnc(SC)nc1Cl.Nc1ccc2ncccc2c1>>CCOC(=O)c1nnc(SC)nc1Nc1ccc2ncccc2c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US04758501,CC(C)(C)c1cc(C(=O)Cl)cc(C(C)(C)C)c1O.CC(C)(C)c1cc(C(=O)Oc2ccc(Cl)c([N+](=O)[O-])c2)cc(C(C)(C)C)c1O.ClCCl.O=C([O-])c1ccccc1>>CC(C)(C)c1cc(C(=O)OCCC(=O)Oc2ccc(Cl)c([N+](=O)[O-])c2)cc(C(C)(C)C)c1O,,ClCCl,,,,val
US20110021521A1,NNc1cnc(-c2ccc(Oc3ccccc3)cc2)cn1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>FC(F)(F)c1nnc2cnc(-c3ccc(Oc4ccccc4)cc3)cn12,,Cc1ccccc1,,,,val
US20120058893A1,C=CCN(C(=O)Cc1c(C)cc(C)cc1C)c1ncsc1C(=O)OC>>C=CCn1c(=O)c(-c2c(C)cc(C)cc2C)c(O)c2scnc21,,CN(C)C=O,,O,[H-].[Na+],val
US20110257100A1,CCOC(CBr)OCC.Ic1c[nH]cn1>>CCOC(Cn1cnc(I)c1)OCC,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20160039804A1,CCN(c1ncc(C(F)(F)F)cc1CO)C1CCOCC1.O=S(Cl)Cl>>CCN(c1ncc(C(F)(F)F)cc1CCl)C1CCOCC1,,CN(C)C=O,,,,val
US20060135619A1,COc1ccc(COc2ccc(C(=O)N(C)c3ccc(Oc4ccccc4)cc3C(=O)NC(C)C)cc2Cl)cc1OC>>CC(C)NC(=O)c1cc(Oc2ccccc2)ccc1N(C)C(=O)c1ccc(O)c(Cl)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110183978A1,CC(C)Nc1nccc(C(=CN(C)C)C(=O)c2ccc(F)cc2)n1.NN>>CC(C)Nc1nccc(-c2c[nH]nc2-c2ccc(F)cc2)n1,,CCO,,O,,val
US04734123,CCOC(=O)CC(C)=O.Nc1nc(S(=O)(=O)Nc2c(Cl)cccc2Cl)n[nH]1>>Cc1cc(O)n2nc(S(=O)(=O)Nc3c(Cl)cccc3Cl)nc2n1,,CO,,CC(=O)O,,val
US20040087577A1,CC(C)C=O.Nn1c(=O)c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc21>>CC(C)C=Nn1c(=O)c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc21,,CC(=O)N(C)C,,,,val
US20030125370A1,CN(C(=O)[C@H]1CCCN1C(=O)OC(C)(C)C)C1CC1>>CN(C(=O)[C@H]1CCCN1)C1CC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US05308854,CCc1cc([N+](=O)[O-])c(Cl)nc1C.CO>>CCc1cc([N+](=O)[O-])c(OC)nc1C,,CCOCC,,[Na],,val
US04276305,C=CCBr.O=Cc1ccc2ccccc2c1>>C=CCC(O)c1ccc2ccccc2c1,,CCOCC,,II,[Mg],val
US20120214735A1,CCOC(=O)c1cc(-c2ccc(O)cc2)no1.Nc1ncc(Br)s1>>CCOC(=O)c1cc(-c2ccc(Oc3cnc(N)s3)cc2)no1,,C1CCOC1,,[H-].[Na+],,val
US20090227588A1,Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)nn1.O=C(Cl)c1cccc(Br)c1>>O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)nn1)c1cccc(Br)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20070249670A1,CC(C)(C)OC(=O)c1cc(-c2ccccc2)sc1N.O=C=Nc1c(Cl)cc(Cl)cc1Cl>>CC(C)(C)OC(=O)c1cc(-c2ccccc2)sc1NC(=O)Nc1c(Cl)cc(Cl)cc1Cl,,CN(C)C=O,,CCN(CC)CC,,val
US20100152165A1,CCOC(=O)CCc1ccc(N(Cc2ccc3c(c2C)N(CCO)CCC3)C(=O)C(F)(F)F)cc1F.CS(=O)(=O)Cl>>CCOC(=O)CCc1ccc(N(Cc2ccc3c(c2C)N(CCOS(C)(=O)=O)CCC3)C(=O)C(F)(F)F)cc1F,,CCOC(C)=O,,CCN(CC)CC,,val
US20020177598A1,C[C@H]1CN(Cc2ccc(F)cc2)[C@@H](CO)CN1.O=C(Cl)COc1ccc(Cl)cc1>>C[C@@H]1CN(Cc2ccc(F)cc2)[C@@H](CO)CN1C(=O)COc1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20080221102A1,ClCCCN1CCOCC1.Oc1ccc(Br)cc1>>Brc1ccc(OCCN2CCOCC2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04772600,CCN(CC)CCCN.O=C(O)Cn1c(-c2ccc(Cl)cc2)nc2cccnc21>>CCN(CC)CCCNC(=O)Cn1c(-c2ccc(Cl)cc2)nc2cccnc21,,C1CCOC1,CC(C)O,O=C(n1ccnc1)n1ccnc1,,val
US06479480B1,C#Cc1cccc(F)c1.Nc1cc(F)ccc1I>>Fc1cccc(-c2cc3ccc(F)cc3[nH]2)c1,[Cu]I,CCNCC,,O=C([O-])[O-].[Ca+2],,val
US20130336921A1,CNCCOCCOCCOCCC(=O)OC(C)(C)C.O=C(Nc1ccc(N2CCCCC2)cc1C(=O)Nc1ccn(-c2cccc(C(F)(F)F)c2)n1)c1cccc(CCl)n1>>CN(CCOCCOCCOCCC(=O)OC(C)(C)C)Cc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2C(=O)Nc2ccn(-c3cccc(C(F)(F)F)c3)n2)n1,,CN(C)C=O,O,[I-].[K+],,val
US20020055630A1,COC(=O)[C@@H](C)NC(=O)c1cccc2c1NC1CCCC21>>C[C@@H](NC(=O)c1cccc2c1NC1CCCC21)C(=O)O,,C1CCOC1,,[Li+].[OH-],,val
US20020173646A1,COc1cc2nc[nH]c(=O)c2cc1OC.O=[N+]([O-])O>>COc1cc2nc[nH]c(=O)c2c([N+](=O)[O-])c1OC,,O,,,,val
US20100099681A1,COC(=O)c1ccccc1Nc1c(-c2cc3nccnc3c(F)c2F)c(C)nn1-c1ccccc1C>>Cc1ccccc1-n1nc(C)c(-c2cc3nccnc3c(F)c2F)c1Nc1ccccc1C(=O)O,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20120220577A1,CCOC(=O)COc1cccc(N)c1.COC(=O)c1cc(OCC(=O)Cl)c2c(Cl)cc(Cl)cc2c1>>CCOC(=O)COc1cccc(NC(=O)COc2cc(C(=O)OC)cc3cc(Cl)cc(Cl)c23)c1,,ClCCl,,CCN(CC)CC,,val
US20130237501A1,CCOC(=O)c1c(-c2ccc(Cl)cc2)oc2cc(N(CS(C)(=O)=O)S(C)(=O)=O)c(C3CC3)cc12>>CS(=O)(=O)Nc1cc2oc(-c3ccc(Cl)cc3)c(C(=O)O)c2cc1C1CC1,,CCO,O,[K+].[OH-],,val
US20100305085A1,CC(C)(C)OC(=O)c1ccc(-n2[nH]cc(-n3ccnn3)c2=O)nc1.Cl>>Cl.O=C(O)c1ccc(-n2[nH]cc(-n3ccnn3)c2=O)nc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20060211656A1,CC(C)(C)OC(=O)N[C@](C)(CCc1ccc(O)c(N)c1)COP(=O)(OC(C)(C)C)OC(C)(C)C.CCOC(=N)c1cccc(OCC)c1.Cl>>CCOc1cccc(-c2nc3cc(CC[C@@](C)(N)COP(=O)(O)O)ccc3o2)c1.Cl,,CO,,,,val
US20050239872A1,CC(C)OC(=O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)C(F)(F)c1ccccc1>>CC(C)OC(=O)CCCCCCN1C(=O)CC[C@@H]1CC[C@@H](O)C(F)(F)c1ccccc1,[Pd],CO,,,,val
US20070135367A1,Nc1cc(C(F)(F)F)ccc1N1CCCCC1.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>O=C(Nc1cc(C(F)(F)F)ccc1N1CCCCC1)c1ccc([N+](=O)[O-])cc1,,O,,CCN(CC)CC,ClCCl,val
US20090163512A1,CS(=O)COc1ccc(Cl)cc1C=O.O=C1Cc2ccc(Cl)cc2N1>>CS(=O)COc1ccc(Cl)cc1/C=C1\C(=O)Nc2cc(Cl)ccc21,,CO,,C1CCNC1,,val
US20070049594A1,C=C(CSCc1ccccc1)C(=O)O.FC(F)Oc1ccccc1CS>>O=C(O)C(CSCc1ccccc1)CSCc1ccccc1OC(F)F,CN(C)c1ccncc1,CN(C)C=O,,,,val
US04408077,Cc1ccccc1CCC(=NO)C(=O)C(F)(F)F.O=S(=O)(O)O>>Cc1cccc2c1CCC(=NO)C2(O)C(F)(F)F.O=S(=O)(O)O,,O,,,,val
US03956495,C1CCNC1.CCN(CC)CCNc1nc(Cl)nc2ccccc12>>CCN(CC)CCNc1nc(N2CCCC2)nc2ccccc12,,C1CCOC1,,Cl,[Na+].[OH-],val
US20060173019A1,C[Si](C)(C)N=C=O.Nc1ccccc1C(=O)c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>O=c1nc(-c2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)c2ccccc2[nH]1,,C1CCOC1,CC(=O)O,,,val
US20130072677A1,C[Si](C)(C)C#Cc1ccc(C2(N)CC2)cc1>>C#Cc1ccc(C2(N)CC2)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(Cl)c(OCCCOC)cc1CC2C(C)C>>COCCCOc1cc2c(cc1Cl)-c1cc(=O)c(C(=O)O)cn1C(C(C)C)C2,,CCO,,Cl,[Na+].[OH-],val
US20080045534A1,Cc1ccc(N)c(C)c1NC(=O)CC(C)(C)C.O=Cc1ccc(C(F)(F)F)cc1>>Cc1ccc(NCc2ccc(C(F)(F)F)cc2)c(C)c1NC(=O)CC(C)(C)C,,C1CCOC1,,CO,[BH4-].[Na+],val
US20150252032A1,CC(C)(C)[Si](C)(C)OCCc1ccccc1C#N.NO>>CC(C)(C)[Si](C)(C)OCCc1ccccc1C(=N)NO,,CO,,Cl,O=C([O-])O.[Na+],val
US04485112,CI.O=C(c1ccc(Cl)cc1)c1cc2ccccc2o1>>CC(O)(c1ccc(Cl)cc1)c1cc2ccccc2o1,,C1CCOC1,,Cl,[Mg],val
US20140080816A1,O=C1NC2CC=CC(F)=C2N2CCCC12>>FC1=C2C(CC=C1)NCC1CCCN21,,C1CCOC1,,B,CO,val
US20070208007A1,CCCN(CCC)CCCCNC(=O)c1cn2c(n1)CCC(CNCc1ncc[nH]1)C2.Cn1ccnc1C=O>>CCCN(CCC)CCCCNC(=O)c1cn2c(n1)CCC(CN(Cc1ncc[nH]1)Cc1nccn1C)C2,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20080166359A1,CC(C)c1cc(C(C)C)c(S(=O)(=O)Cl)c(C(C)C)c1.O=C(c1cscc1Nc1ccc(I)cc1F)N1CC(O)(CO)C1>>CC(C)c1cc(C(C)C)c(S(=O)(=O)OCC2(O)CN(C(=O)c3cscc3Nc3ccc(I)cc3F)C2)c(C(C)C)c1,CN(C)c1ccncc1,ClCCl,,,,val
US06080781,O=C1CCCc2cc(O)ccc21.O=Cc1ccc(O)cc1>>O=C1C(=Cc2ccc(O)cc2)CCc2cc(O)ccc21,,O,,CO,Cl,val
US20060142569A1,N=C(N)N.O=[N+]([O-])c1ccccc1>>Nc1nnc2ccccc2n1,,CS(C)=O,,Cl,CC(C)(C)[O-].[K+],val
US20120196864A1,O=C1CSC(=O)N1.O=Cc1ccc(OCc2ccc(C(F)(F)F)cc2C(F)(F)F)cc1Cl>>O=C1NC(=O)/C(=C/c2ccc(OCc3ccc(C(F)(F)F)cc3C(F)(F)F)cc2Cl)S1,,CCO,,C1CCNCC1,,val
US20040009995A1,COC(=O)c1cc(S(=O)(=O)c2cc(Br)cc(OC(C)(C)C)c2)c([N+](=O)[O-])s1.C[S-]>>COC(=O)c1cc(S(=O)(=O)c2cc(Br)cc(OC(C)(C)C)c2)c(SC)s1,,C1CCOC1,CCOC(C)=O,CC(=O)O,,val
US20090137607A1,C[Si](C)(C)C#Cc1cnn2cc(-c3ccccc3)c(-c3ccc(CN4CCC(c5n[nH]c(-c6ccccn6)n5)CC4)cc3)nc12>>C#Cc1cnn2cc(-c3ccccc3)c(-c3ccc(CN4CCC(c5n[nH]c(-c6ccccn6)n5)CC4)cc3)nc12,,CO,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US06258948B1,CN(C)C=O.COC(=O)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CNc2ccccc21.O=C=NCc1ccccc1>>COC(=O)CN1C(=O)[C@@H](NC(=O)c2ccccc2)CN(C(=O)NCc2ccccc2)c2ccccc21,,CN(C)C=O,ClCCl,,,val
US20080207703A1,COc1ccc(CN)c(OC)c1.O=C(NCc1ccc(Cl)c(Cl)c1)Nc1nc(CI)cs1>>COc1ccc(CNCc2csc(NC(=O)NCc3ccc(Cl)c(Cl)c3)n2)c(OC)c1,,C1CCOC1,,,,val
US06627651B1,CCCOCCOc1ccccc1COc1ccc2c(c1)C=C(C(=O)OC)CCS2(=O)=O>>CCCOCCOc1ccccc1COc1ccc2c(c1)C=C(C(=O)O)CCS2(=O)=O,,C1CCOC1,CO,O=C([O-])[O-].[K+].[K+],,val
US20030111107A1,Brc1ccccc1-c1ccccc1.O=C1c2cc(Br)ccc2-c2ccc(Br)cc21>>OC1(c2ccccc2-c2ccccc2)c2cc(Br)ccc2-c2ccc(Br)cc21,,CCOCC,,[Mg],,val
US20080045742A1,COCCO.O=CC=Cc1ccccc1>>COCCOC(=O)C=Cc1ccccc1,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20080146565A1,O=S(=O)(c1ccccc1)n1cc(-c2ccnc(N[C@@H]3CC[C@@H](O)CC3)n2)c2ccccc21>>O[C@@H]1CC[C@@H](Nc2nccc(-c3c[nH]c4ccccc34)n2)CC1,,CO,,[Na+].[OH-],,val
US20160075711A1,COc1ccc(Br)c(COC(C)=O)n1>>COc1ccc(Br)c(CO)n1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20100261732A1,COc1ccccc1N1CCN(CCC(=O)NN)CC1.O=C=Nc1ccccc1>>COc1ccccc1N1CCN(CCC(=O)NNC(=O)Nc2ccccc2)CC1,,Cc1ccccc1,,,,val
US20110201604A1,CCOc1ccc2nc(N)sc2c1.CN(C)C=O.CNc1ccc(C(=O)NCC(=O)N(C)C)cc1N>>CCOc1ccc2nc(Nc3nc4cc(C(=O)NCC(=O)N(C)C)ccc4n3C)sc2c1,,CN(C)C=O,,ClCCCl,,val
US20050080074A1,COC(=O)C(C)N1C(=O)c2ccccc2CC1C(=O)OC>>CC(CO)N1C(=O)c2ccccc2CC1CO,,C1CCOC1,ClCCl,CO,[BH4-].[Li+],val
US20080153846A1,BrCc1ccccc1.CCCCN1CCN(CC(=O)OC)C(=O)C1=O>>CCCCN1CCN(C(Cc2ccccc2)C(=O)OC)C(=O)C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20050009804A1,COC(=O)c1sc(-c2ccccc2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C1CCSCC1.O=C(O)c1ccccc1C(=O)OO>>COC(=O)c1sc(-c2ccccc2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C1CCS(=O)CC1,,CCO,O,[Mg],,val
US20120058123A1,CN.COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2)c1C=O>>CNCc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)OC)ccc1OC,CC(=O)O,ClCCl,,[BH3-]C#N.[Na+],,val
US20150291595A1,CNS(=O)(=O)c1ccc(O)cc1.O=C(Cl)c1c(Cl)ncnc1Cl>>CNS(=O)(=O)c1ccc(OC(=O)c2c(Cl)ncnc2Cl)cc1,,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20160272602A1,CC(=O)N1CCNCC1.COc1c(Cl)cccc1C=O>>COc1c(Cl)cccc1CN1CCN(C(C)=O)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04469868,CCn1nc(C)c2nc(C)nc(N3CC3C)c21>>CCn1nc(C)c2c1C1=NC(C)CN1C(C)=N2,,CC(C)=O,,[I-].[Na+],,val
US06313136B1,CCOc1ccc(N)cc1.CCc1cccc(C)c1CNc1cc(C(=O)O)cn2c(C)c(C)nc12>>CCOc1ccc(NC(=O)c2cc(NCc3c(C)cccc3CC)c3nc(C)c(C)n3c2)cc1,,ClCCl,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20080255197A1,Cc1cc(Cl)cnc1CN(Cc1nccc2ccccc12)C1CCNCC1.O=C(NO)Oc1ccccc1>>Cc1cc(Cl)cnc1CN(Cc1nccc2ccccc12)C1CCN(C(=O)NO)CC1,,C1CCOC1,,,,val
US20120309739A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3oc4ncc(Cl)nc4c3I)cc2)CCC1.OB(O)c1ccccc1>>NC1(c2ccc(-c3oc4ncc(Cl)nc4c3-c3ccccc3)cc2)CCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20070010542A1,Cc1c(OCC2OCC3(CC3)CO2)ccnc1CO.Sc1nc2ccccc2[nH]1>>Cc1c(OCC2OCC3(CC3)CO2)ccnc1CSc1nc2ccccc2[nH]1,,C1CCOC1,CO,CCN(CC)CC,CS(=O)(=O)Cl,val
US20110015202A1,CCOC(=O)Cn1ccc(-n2cc(C#Cc3cccc(C)c3)nc2C)cc1=O.CN>>CNC(=O)Cn1ccc(-n2cc(C#Cc3cccc(C)c3)nc2C)cc1=O,,CCO,,,,val
US20090275537A1,CN(C(=O)NCc1cccc(F)c1Cl)[C@H](COC(=O)Nc1cc2cc(F)ccc2cn1)CC(O)CO>>CN(C(=O)NCc1cccc(F)c1Cl)[C@H](COC(=O)Nc1cc2cc(F)ccc2cn1)C[C@H](O)CO,,ClCCl,,CO,,val
US20100016319A1,C1COCCN1.CN(C)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2ccnc(Cl)n2)c1>>CN(C)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2ccnc(N3CCOCC3)n2)c1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20060069088A1,CC(C)(C)Oc1ccc(C(F)(F)F)cc1CN.Cc1ccc(C)n1C1C=C[C@@](C(=O)O)(C(C)C)C1>>Cc1ccc(C)n1C1C=C[C@@](C(=O)NCc2cc(C(F)(F)F)ccc2OC(C)(C)C)(C(C)C)C1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030207889A1,BrC1CCNCC1.O=C(Cl)c1ccccc1>>O=C(c1ccccc1)N1CCC(Br)CC1,,C1CCOC1,,Br,CCN(CC)CC,val
US20040132769A1,Nc1c(Cl)ccc(C2CC2)c1F.O=C1CCC(=O)N1Br>>Nc1c(Cl)cc(Br)c(C2CC2)c1F,,CN(C)C=O,,,,val
US20160115168A1,CC(C)(C)OC(=O)N1CC[C@H](OS(C)(=O)=O)C1.Clc1ncnc2[nH]cc(I)c12>>CC(C)(C)OC(=O)N1CC[C@@H](n2cc(I)c3c(Cl)ncnc32)C1,,CC#N,CO,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04873262,CCCN(CCC)C1CCc2cccc(CNC(C)=O)c2C1>>CCCN(CCC)C1CCc2cccc(CN)c2C1,,CCO,,[K+].[OH-],,val
US05300668,COC(=O)Cc1ccc(CO[Si](C)(C)C(C)(C)C)cc1.ClC/C=C\CCl>>C=CC1CC1(C(=O)OC)c1ccc(CO[Si](C)(C)C(C)(C)C)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US05665737,COc1ccc(CC(=O)Nc2cccc([N+](=O)[O-])c2O)cc1OC1CCCC1>>COc1ccc(Cc2nc3cccc([N+](=O)[O-])c3o2)cc1OC1CCCC1,,Cc1ccccc1C,O,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20030220495A1,C=O.CC(=O)c1ccc(F)cc1.CNC.Cl>>CN(C)CC(=O)Cc1ccc(F)cc1.Cl,,CCO,,CC(C)=O,,val
US20100316656A1,COC(=O)CCCBr.OCc1cc(O)cc(CO)c1>>COC(=O)CCCOc1cc(CO)cc(CO)c1,,C1CCOC1,,[I-].[K+],,val
US05453427,CI.COC(=O)Cc1c(C)nc(S)nc1O>>COC(=O)Cc1c(C)nc(SC)nc1O,,[Na+],[OH-],,,val
US20040249173A1,CC(=O)[O-].NO.O=Cc1ccc2c(c1)C=CC(=CCl)CO2>>CC(=NO)c1ccc2c(c1)C=CC(=CCl)CO2,,CO,,Cl,,val
US20110034433A1,CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(C)(=O)=O)N(C(=O)N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)C(=O)N1c1cccc(C(F)(F)F)c1>>CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(C)(=O)=O)N(C(=O)N2CCC[C@@H](N)C2)C(=O)N1c1cccc(C(F)(F)F)c1,,C1COCCO1,Cl,,,val
US20110288063A1,CC12CCC(CC1=O)C2(C)C.CCOC(=O)C(=O)OCC>>CCOC(=O)/C(O)=C1\CC2CC(C1=O)C2(C)C,,C1CCOC1,CCO,Cl,[H-].[Na+],val
US05177106,COC(=O)C(C)(C)CCCOc1cc(C)c(N)cc1C.O=C1OC(=O)c2ccccc21>>COC(=O)C(C)(C)CCCOc1cc(C)c(N2C(=O)c3ccccc3C2=O)cc1C,,Cc1ccccc1,,,,val
US20120196884A1,Nc1ccccc1.O=C=Nc1cc([N+](=O)[O-])ccc1Cl>>O=C(Nc1ccccc1)Nc1cc([N+](=O)[O-])ccc1Cl,,CCOC(C)=O,,,,val
US20050176701A1,NCCC1(C2CCCC2)CC(=O)CC(=O)O1.O=C(O)CCc1ccco1>>O=C1CC(=O)OC(CCNC(=O)CCc2ccco2)(C2CCCC2)C1,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20100113782A1,CC(C)(C)CC(=O)Cl.Cc1ccc(NC(=O)c2ccc(N3CCNCC3)nc2)cc1I>>Cc1ccc(NC(=O)c2ccc(N3CCN(C(=O)CC(C)(C)C)CC3)nc2)cc1I,,CCOC(C)=O,ClCCl,,,val
US20110218192A1,CC(=O)c1cc(Br)ccc1O.O=Cc1cccc(Cl)c1>>O=C(C=Cc1cccc(Cl)c1)c1cc(Br)ccc1O,,COC(C)(C)C,,CCO,[Na+].[OH-],val
US04786310,C=CCn1c(=O)sc2cc(F)c(NC(=S)N3CCCCN3C(=O)OCC)cc21>>C=CCn1c(=O)sc2cc(F)c(-n3c(=O)n4n(c3=S)CCCC4)cc21,,O,,C[O-].[Na+],,val
US20150152046A1,N[C@@H](CS)C(=O)O.O=C1CCCC(=O)C1Br>>O=C1CCCC2=C1SC[C@@H](C(=O)O)N2,,CO,,c1ccncc1,,val
US20080081810A1,CC(=O)N1CCN(C(=O)Cl)CC1.CC(C)N(CCN)C1(Cc2cccc(Cl)c2)C(=O)Nc2cc(Br)ccc21>>CC(=O)N1CCN(C(=O)NCCN(C(C)C)C2(Cc3cccc(Cl)c3)C(=O)Nc3cc(Br)ccc32)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100113782A1,C1COCCN1.Cc1ccc(NC(=O)c2ccc(Cl)nc2)cc1I>>Cc1ccc(NC(=O)c2ccc(N3CCOCC3)nc2)cc1I,CN(C)c1ccncc1,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20110201635A1,CC(C)(CC=O)CCO[Si](C)(C)C(C)(C)C.O=C1Cc2ccc(Cl)cc2N1>>CC(C)(C/C=C1\C(=O)Nc2cc(Cl)ccc21)CCO[Si](C)(C)C(C)(C)C,,CO,,C[O-].[Na+],,val
US20150126490A1,CC(C)(C)C(=O)Nc1ncc([C@@H]2CCC[C@H](O[Si](C)(C)C(C)(C)C)C2)nc1Br.CS(=O)(=O)Cl>>CC(C)(C)C(=O)Nc1ncc([C@@H]2CCC[C@H](OS(C)(=O)=O)C2)nc1Br,,ClCCl,,O,,val
US20100216813A1,BrP(Br)Br.COc1ccc(CO)c(Cl)c1OC>>COc1ccc(CBr)c(Cl)c1OC,,CCOCC,,O=C([O-])O.[Na+],,val
US20050245524A1,Cc1cc(Br)cc2nnc(N)nc12.O=[N+]([O-])c1cccc(B(O)O)c1>>Cc1cc(-c2cccc([N+](=O)[O-])c2)cc2nnc(N)nc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20080103123A1,CC(C)(C)OC(=O)N1CCC(NCc2ccc(Br)cn2)CC1.CS(=O)(=O)c1ccc(B(O)O)cc1>>CC(C)(C)OC(=O)N1CCC(NCc2ccc(-c3ccc(S(C)(=O)=O)cc3)cn2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,O,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20110039829A1,CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OC3(C(=O)OCC)CCC3)n(-c3ccccc3)n2)CC1>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OC3(C(=O)O)CCC3)n(-c3ccccc3)n2)CC1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20110005947A1,C1CCNC1.O=C=Nc1cc([N+](=O)[O-])ccc1F>>Nc1ccc(F)c(NC(=O)N2CCCC2)c1,,ClCCl,,,,val
US20070208046A1,O=c1cc(OCc2ccccc2)ccn1-c1ccc(OC2CCCCO2)cc1>>O=c1cc(OCc2ccccc2)ccn1-c1ccc(O)cc1,,CCO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20080318935A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(F)C(N)C(=O)O>>CC(C)(C)OC(=O)NC(C(=O)O)C(C)(C)F,,CO,,CCN(CC)CC,,val
US04478838,CCCCCNC(=O)C(C)N1CCNCC1.COc1cc(C=CC(=O)Cl)cc(OC)c1OC>>CCCCCNC(=O)C(C)N1CCN(C(=O)C=Cc2cc(OC)c(OC)c(OC)c2)CC1,,ClC(Cl)Cl,,,,val
US20070265225A1,COC(=O)C1(NCC2(NC(=O)OC(C)(C)C)CCc3c(F)cc(F)cc32)CCCC1.Cl>>COC(=O)C1(NCC2(N)CCc3c(F)cc(F)cc32)CCCC1.Cl,,CCOC(C)=O,,,,val
US20090137609A1,CC(C)(O)c1ccc(Br)cc1.C[Si](C)(C)n1ccnc1>>CC(C)(O[Si](C)(C)C)c1ccc(Br)cc1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US05051412,CN(C)c1ccc([N+](=O)[O-])c(CC#N)n1>>CN(C)c1ccc2[nH]ccc2n1,[Ni],CCOC(C)=O,,,,val
US05189045,CNC1CCN(CC2Cc3ccccc32)CC1.O=CO>>CN(C=O)C1CCN(CC2=Cc3ccccc32)CC1,,O=CO,,CC(=O)OC(C)=O,,val
US20080200483A1,CCC(=O)N(C(=O)OC(C)(C)C)[C@H]1C[C@@H](n2cnc3c(NC(CC)CC)nc(Cl)nc32)[C@H](O)[C@@H]1O>>CCC(=O)N[C@H]1C[C@@H](n2cnc3c(NC(CC)CC)nc(Cl)nc32)[C@H](O)[C@@H]1O,,ClCCl,,O=C(O)C(F)(F)F,,val
US06300352B1,O=S(=O)(Cl)c1cc(F)c(Br)cc1F.[NH4+]>>NS(=O)(=O)c1cc(F)c(Br)cc1F,,C1CCOC1,,O,,val
US20060189646A1,CCOC(=O)C(NS(=O)(=O)c1c(C)cc(C)cc1C)C(F)(F)F>>Cc1cc(C)c(S(=O)(=O)NC(CO)C(F)(F)F)c(C)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120208827A1,O=C(Cl)C1CC1.O=[N+]([O-])c1cc(F)ccc1NC[C@@H]1CCNC1>>O=C(C1CC1)N1CC[C@@H](CNc2ccc(F)cc2[N+](=O)[O-])C1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US07638648B2,C#Cc1cc(OC)c2c(c1)C(C)(C)CCC2N(C)C1CC1.COC(=O)Cc1ccc(I)cc1>>COC(=O)Cc1ccc(C#Cc2cc(OC)c3c(c2)C(C)(C)CCC3N(C)C2CC2)cc1,[Cu]I,CCCCCC,,CCN(CC)CC,CCOC(C)=O,val
US20120232056A1,CC(C)OB1OC(C)(C)C(C)(C)O1.Fc1ccc(-c2ccco2)cc1>>CC1(C)OB(c2ccc(-c3ccc(F)cc3)o2)OC1(C)C,,C1CCOC1,,[Li]CCCC,,val
US20090082359A1,O=C1NC(=O)c2ccccc21.O=c1cc(-c2ccc(C(F)(F)F)cc2)ccn1-c1ccc2c(cnn2CCCCl)c1>>O=C1c2ccccc2C(=O)N1CCCn1ncc2cc(-n3ccc(-c4ccc(C(F)(F)F)cc4)cc3=O)ccc21,,CN(C)C=O,O,[K],,val
US20070135594A1,BrBr.Cc1cccc(C)c1N>>Cc1cc(Br)cc(C)c1N,,CC(=O)O,,,,val
US04281141,ClCc1c[nH]cn1.N#CC(c1ccccc1)c1ccccc1>>N#CC(Cc1c[nH]cn1)(c1ccccc1)c1ccccc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20070004675A1,CNC.O=Cc1ccc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)nc1>>CN(C)Cc1ccc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)nc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20060052445A1,O=S(=O)(c1ccc(F)cc1)c1ccc(/C=C/c2ccc(F)cc2)nc1>>O=S(=O)(c1ccc(F)cc1)c1ccc(CCc2ccc(F)cc2)nc1,[Pd],CCO,,CCOC(C)=O,[H][H],val
US20090124687A1,CC(=O)c1cc2cccc(OC(C)c3ccccc3)c2o1.CCN(CC)C(=O)CP(=O)(O)O>>CCN(CC)C(=O)/C=C(\C)c1cc2cccc(OC(C)c3ccccc3)c2o1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20050032786A1,COC(=O)c1ccccc1S.N#Cc1cccc(Cl)n1>>O=c1nc(-c2cccc(Cl)n2)sc2ccccc12,,Cc1ccccc1,,CCN(CC)CC,,val
US20080262048A1,CC(C)(C)[Mg]Cl.N#Cc1cccc(Cl)c1.O>>CC(C)(C)C(=O)c1cccc(Cl)c1,Cl[Cu],C1CCOC1,ClCCl,Cl,,val
US04977256,Cc1nnsc1C(=O)OCc1ccc([N+](=O)[O-])cc1>>Cc1nnsc1C(=O)O,[Zn],C1CCOC1,,,,val
US20070093480A1,CN1CCNCC1.COc1cc2c(-c3cc4cc(F)cnc4n3S(=O)(=O)c3ccc(C)cc3)cn(CCI)c2cc1OC>>COc1cc2c(-c3cc4cc(F)cnc4n3S(=O)(=O)c3ccc(C)cc3)cn(CCN3CCN(C)CC3)c2cc1OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090298820A1,COc1ccc(Br)c(O[Si](C)(C)C(C)(C)C)c1C(=O)CBr>>COc1ccc(Br)c2c1C(=O)CO2,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20030236199A1,CCc1cccc(CN(CC(O)C(Cc2cc(O)cc(F)c2)NC(=O)CN)C(=O)OC(C)(C)C)c1.O=C(Cl)CCCCBr>>CCc1cccc(CN(CC(O)C(Cc2cc(O)cc(F)c2)NC(=O)CNC(=O)CCCCBr)C(=O)OC(C)(C)C)c1,,CCOC(C)=O,,C1CCOC1,CCN(CC)CC,val
US20030229079A1,CC(=O)c1cc(Cn2cccn2)cc(Cn2cccn2)c1.COC(=O)c1cc(C)ccn1>>Cc1ccnc(C(=O)CC(=O)c2cc(Cn3cccn3)cc(Cn3cccn3)c2)c1,,C1CCOC1,,C[O-].[Na+],,val
US04582909,COc1ccc(C(=O)Cl)cc1.O=C1Cc2cccc(CC(=O)OCc3ccccc3)c2N1>>COc1ccc(C(=O)N2C(=O)Cc3cccc(CC(=O)OCc4ccccc4)c32)cc1,,Cc1ccccc1,,CCN(CC)CC,,val
US04411900,Cc1nc(CCl)cs1.Cl.Cl.c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>Cc1nc(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)cs1.Cl.Cl.Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140148574A1,CCC[C@H](N=[N+]=[N-])[C@H](O)C(=O)OC.Cl>>CCC[C@H](N)[C@H](O)C(=O)OC.Cl,[Pd],CO,O,,,val
US05684143,COc1ccc(C(Cl)(c2ccccc2)c2ccccc2)cc1.N[C@@H]1[C@@H](COC(=O)c2ccccc2)O[C@@H](n2ccc(=O)[nH]c2=O)[C@@H]1F>>COc1ccc(C(N[C@@H]2[C@@H](CO)O[C@@H](n3ccc(=O)[nH]c3=O)[C@@H]2F)(c2ccccc2)c2ccccc2)cc1,,c1ccncc1,,O=C([O-])O.[Na+],,val
US04013651,C1CCNCC1.CS(=O)(=O)OC1=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)N2C(=O)C(NC(=O)COc3ccccc3)[C@H]2SC1>>O=C(COc1ccccc1)NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(N3CCCCC3)CS[C@H]12,,CN(C)C=O,,,,val
US20140288077A1,COc1ccc(COc2ccc(Oc3c(I)cc(C[C@@H](CN)NC(=O)OC(C)(C)C)cc3I)cc2)cc1>>NC[C@@H](N)Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20110275673A1,CCCCCCCC#CC(=O)c1ccc(C#N)cc1.NN>>CCCCCCCc1cc(-c2ccc(C#N)cc2)[nH]n1,,CCO,,Cl,Cl,val
US20030220324A1,CC(C)(C)OC(=O)NCCNc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)OC(C)(C)C)CC1>>NCCNc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1,,CCOC(C)=O,,Cl,,val
US20080269288A1,CCOC(=O)CO[C@@H]1CCN(C(=O)OC(C)(C)C)C1.Cl>>CCOC(=O)CO[C@@H]1CCNC1.Cl,,C1COCCO1,,,,val
US20020099007A1,CCOC(=O)C(CCCc1cccc(OC)c1)C(=O)OCC>>COc1cccc(CCCCC(=O)O)c1,,O,OCCO,Cl,[K+].[OH-],val
US20100286173A1,CNOC.Cc1ccc(C(=O)Cl)cc1C(F)(F)F>>CON(C)C(=O)c1ccc(C)c(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,Cl,val
US20070015802A1,CC(=O)O.CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4cc(F)c(Cl)cc4Cl)oc23)[C@@H]1CO>>CC(=O)O.CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4cc(F)c(Cl)cc4Cl)oc23)[C@@H]1CO,,CO,,,,val
US04283544,CC(C)=CCBr.CC1=NCCO1.CCO>>CCOC1(C)OCCN1CC=C(C)C,,CCCCCC,CCO,C,C[O-].[Na+],val
US20090270460A1,Cc1nc(OCc2c(C(C)C)cnn2-c2ccccc2OC(F)(F)F)ccc1[N+](=O)[O-]>>Cc1nc(OCc2c(C(C)C)cnn2-c2ccccc2OC(F)(F)F)ccc1N,O=[Pt],C1CCOC1,CCO,,,val
US20140275016A1,NC(=O)C1CCOCC1.Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cn1.O=C(Cl)C(=O)Cl>>O=C(NC(=O)C1CCOCC1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cn1,,C1CCOC1,ClCCCl,O,,val
US05756783,CC(=O)OC(C)=O.CC(C)[C@H](C)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C>>CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]4(C)CC[C@@H]32)C1,,c1ccncc1,,O,,val
US20070254931A1,CC(=O)Nc1nc(CCc2ccc(CCN)cc2)cs1.CSC(C)=N>>CC(=N)NCCc1ccc(CCc2csc(NC(C)=O)n2)cc1,,CO,,I,,val
US20140243374A1,COC(=O)c1ccc(CO)cc1.O=S(=O)(NC1CCOCC1)c1ccc(Cl)cc1>>COC(=O)c1ccc(CN(C2CCOCC2)S(=O)(=O)c2ccc(Cl)cc2)cc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05506256,CC(C)(C)OC(=O)N1CCC[C@H]1C1CO1.OCc1ccccc1>>OC(COCc1ccccc1)[C@@H]1CCCN1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20070185133A1,BrBr.CC(=O)c1ccc(Br)s1>>O=C(CBr)c1ccc(Br)s1,,CC(=O)O,,,,val
US05068325,Cc1cccnc1C=CCCl.Nc1nc2c(s1)CCNCC2>>Cc1cccnc1C=CCN1CCc2nc(N)sc2CC1,,ClC(Cl)Cl,,CCOCC,Cl,val
US20150038438A1,C=CCCC(O)c1ccc(N(C)C)cc1C=C>>CN(C)c1ccc2c(c1)C=CCCC2O,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,Cc1ccccc1,,,,val
US05034417,CCNC(=O)c1ccc([N+](=O)[O-])c(Sc2ccc(F)cc2F)c1>>CCNC(=O)c1ccc(N)c(Sc2ccc(F)cc2F)c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20130059849A1,C1CCOC1.Cc1cc(C)c(CNC(=O)c2cc(C#Cc3ccncc3)nc3c2cnn3C(C)C)c(=O)[nH]1>>Cc1cc(C)c(CNC(=O)c2cc(CCc3ccccc3)nc3c2cnn3C(C)C)c(=O)[nH]1,[Pd],CCO,,,,val
US20100036126A1,CCN(CC)CC.CN1CCNC(c2ccccc2)C1.COC(=O)C(=O)Cl>>CN1CCNC(c2ccccc2)C1.COC(=O)C(N)=O,,ClCCl,,,,val
US20070004736A1,O=C(CC1CCN(C(=O)CCS(=O)(=O)c2ccc3cc(Cl)ccc3c2)CC1)c1c[nH]cn1>>O=C(CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(CC(O)c2c[nH]cn2)CC1,,CO,,Cl,[BH4-].[Na+],val
US20080214448A1,CC(=O)Cl.COC(=O)CCCCc1nc(-c2ccccc2N)co1>>COC(=O)CCCCc1nc(-c2ccccc2NC(C)=O)co1,,C1CCOC1,,CCN(CC)CC,,val
US20100311966A1,CCc1[nH]c(C(=O)N[C@H]2CCN(c3ccc(NC(C)=O)c(C(=O)OC)c3)C[C@H]2OC)nc1Cl>>CCc1[nH]c(C(=O)N[C@H]2CCN(c3ccc(NC(C)=O)c(C(=O)O)c3)C[C@H]2OC)nc1Cl,,C1CCOC1,CO,[Li+].[OH-],,val
US03959338,CC(C)(CO)NCC(O)COc1ccccc1C#N.Cl>>CC(C)(CO)NCC(O)COc1ccc(Cl)cc1C#N,,CCOCC,,OO,,val
US20070003539A1,CC(=O)c1ccccc1S(=O)(=O)C(C)C>>CC(O)c1ccccc1S(=O)(=O)C(C)C,,CO,,[BH4-].[Na+],,val
US20010025045A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc2c(c1)CCNC2>>CC(C)(C)OC(=O)N1CCc2cc(N)ccc2C1,,C1COCCO1,,[Na+].[OH-],,val
US20080032969A1,C1COCCN1.COC(=O)CNc1nc(-c2ccc(F)cc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1>>Cc1cc(F)ccc1-c1nc(NCC(=O)N2CCOCC2)nc2c1ccc(=O)n2-c1c(F)cccc1F,,CCOC(C)=O,ClCCl,C[Al](C)C,,val
US20140350019A1,CCOC(=O)CBr.N#Cc1cc(CNc2c(F)ccc(O)c2F)cc(-c2cccc(F)c2)c1>>CCOC(=O)COc1ccc(F)c(NCc2cc(C#N)cc(-c3cccc(F)c3)c2)c1F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05348684,CCCCCCCCOc1cnc(-c2ccc(O)cc2)nc1.C[Si](C)(C)CCCCO>>CCCCCCCCOc1cnc(-c2ccc(OCCCC[Si](C)(C)C)cc2)nc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090105214A1,CN1CCOc2c(ccc(F)c2Cl)C1=O>>CN1CCOc2cc(F)ccc2C1=O,[Pd],CO,,O=C[O-].[NH4+],,val
US20140309225A1,CN(C)c1nn(C)c2ccc([N+](=O)[O-])cc12>>CN(C)c1nn(C)c2ccc(N)cc12,[Pd],CO,,,,val
US20130252937A1,CC1(C)OB(c2cncnc2)OC1(C)C.Cc1cc(I)cc(C)c1Br>>Cc1cc(-c2cncnc2)cc(C)c1Br,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20120115841A1,CC1CCC(C)N1.N#CCCCBr>>CC1CCC(C)N1CCCCN,,CC#N,,N#N,O=C([O-])[O-].[K+].[K+],val
US20070135385A1,COc1nccc2c1cc(C)n2Cc1ccccc1-c1ccccc1>>Cc1cc2c(O)nccc2n1Cc1ccccc1-c1ccccc1,,CC(=O)O,,,,val
US20140148487A1,CCCCCCCCCCCCCCBr.Cc1ccc(O)c(C)c1>>CCCCCCCCCCCCCCOc1ccc(C)cc1C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100331317A1,CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN)ccc21.O=Cc1ccncc1>>CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCNCc3ccncc3)ccc21,,CCOC(C)=O,O,CO,[BH4-].[Na+],val
US20060116406A1,COc1cc(Br)ccc1C(=O)c1ccc(F)cc1>>O=C(c1ccc(F)cc1)c1ccc(Br)cc1O,,CCOCC,,Cl,c1ccncc1,val
US20070232583A1,CC(C)(C)NS(=O)(=O)c1ccc(-c2cn(-c3nc(-c4ccc(Cl)c(Cl)c4)cc(C(F)(F)F)n3)cn2)s1>>NS(=O)(=O)c1ccc(-c2cn(-c3nc(-c4ccc(Cl)c(Cl)c4)cc(C(F)(F)F)n3)cn2)s1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100094000A1,Cc1nn(CC(F)(F)COC(=O)CNC(=O)OC(C)(C)C)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2>>Cc1nn(CC(F)(F)COC(=O)CN)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2,,CCOC(C)=O,,Cl,,val
US04471105,BrCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.CCNCC.[Br-]>>Br.CCN(CC)CCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-],,CCO,,,,val
US20080132540A1,CC(=O)N1CCc2ccc(N)cc21.O=C1CCN(Cc2ccccc2)C1>>CC(=O)N1CCc2ccc(NC3CCN(Cc4ccccc4)C3)cc21,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120208827A1,N#Cc1cccc([N+](=O)[O-])c1NC[C@@H]1CCN(C(=O)C2CC2)C1>>N#Cc1cccc(N)c1NC[C@@H]1CCN(C(=O)C2CC2)C1,[Pd],CCO,,,,val
US20110046147A1,COc1ccc(B(O)O)cc1.COc1cccc(-c2nc(Br)cs2)c1>>COc1ccc(-c2csc(-c3cccc(OC)c3)n2)cc1,,CCCCCC,CCOC(C)=O,,,val
US20140296252A1,Cc1cc(N)nc(C)c1Oc1ccnc(-c2cnn(C)c2)c1.ICI>>Cc1cc(I)nc(C)c1Oc1ccnc(-c2cnn(C)c2)c1,,CC#N,,CC(C)(C)ON=O,,val
US20100056576A1,COC(=O)c1ccc(F)c(-c2c(F)ccc(OCc3ccccc3)c2F)n1>>COC(=O)c1ccc(F)c(-c2c(F)ccc(O)c2F)n1,[Pd],CCOC(C)=O,CO,,,val
US20100069367A1,C=O.CS(=O)(=O)c1cccc(-c2ccc(-n3cc([C@H]4CCCN4)nc3-c3ccccc3C(F)(F)F)cc2)c1>>CN1CCC[C@@H]1c1cn(-c2ccc(-c3cccc(S(C)(=O)=O)c3)cc2)c(-c2ccccc2C(F)(F)F)n1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20050245504A1,O=Cc1occc1Br.OCCO>>Brc1ccoc1C1OCCO1,,c1ccccc1,,O=C([O-])O.[Na+],,val
US20160009677A1,C=Cc1ccc(OC(C)=O)cc1.CCOC(=O)C=[N+]=[N-]>>CCOC(=O)[C@H]1C[C@@H]1c1ccc(OC(C)=O)cc1,,ClC(Cl)Cl,,,,val
US06008229,CC(C)(C)[Si](OCc1c(Cl)ccc(-n2cccc2)c1Cl)(c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Cl>>CC(C)(C)[Si](OCc1c(Cl)ccc(-n2cccc2Cl)c1Cl)(c1ccccc1)c1ccccc1,,C1CCOC1,,O,,val
US20080070912A1,CC(C)C(=NO)c1c(-c2ccc(Cl)cc2)nn2ccccc12.C[Si](C)(C)N=C=O>>CC(C)C(=NOC(N)=O)c1c(-c2ccc(Cl)cc2)nn2ccccc12,,C1CCOC1,,c1ccncc1,,val
US20140329794A1,Nc1cccc(C(=O)NCC(O)CN2CCc3ccccc3C2)c1.O=C1CCOC1>>O=C(NCC(O)CN1CCc2ccccc2C1)c1cccc(NC2CCOC2)c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20050043295A1,O=C(OO)c1cccc(Cl)c1.O=[N+]([O-])c1cccc(C(Cl)=NOCCCN2CCCCC2)c1>>O.O.O=[N+]([O-])c1cccc(C(Cl)=NOCCC[N+]2([O-])CCCCC2)c1,,ClC(Cl)Cl,,,,val
US20030004172A1,CCOC(=O)c1cc2c(=O)n(Cc3ccccc3)c(=O)[nH]c2s1>>O=C(O)c1cc2c(=O)n(Cc3ccccc3)c(=O)[nH]c2s1,,O,,C1CCOC1,[Li+].[OH-],val
US20050240021A1,BrBr.COc1cc(-c2cn3ccsc3n2)ccc1-c1ccccn1>>COc1cc(-c2nc3sccn3c2Br)ccc1-c1ccccn1,,ClCCl,,,,val
US04659651,Cn1c(Cl)cc(=O)n(C)c1=O.N#CCC#N>>Cn1c(C(C#N)C#N)cc(=O)n(C)c1=O,,C1CCOC1,O,Cl,[H-].[Na+],val
US20160257653A1,CC(C)(C)OC(=O)NCCc1cc([N+](=O)[O-])ccc1F>>CC(C)(C)OC(=O)NCCc1cc(N)ccc1F,[Pd],CO,,,,val
US20140315917A1,O=C(NCCCl)N[C@H]1CCOC1>>O=C1NCCN1[C@H]1CCOC1,,C1CCOC1,,[H-].[Na+],,val
US20080139505A1,C=[N+]=[N-].CCC(=O)c1ccc(OCc2ccc(C(OC3CCCCO3)c3cccc(C(=O)O)c3)cc2)c(C)c1O.O=C(Cl)C(=O)Cl>>CCC(=O)c1ccc(OCc2ccc(C(OC3CCCCO3)c3cccc(C(=O)CCl)c3)cc2)c(C)c1O,CN(C)C=O,C1CCOC1,,,,val
US20040138065A1,ClCCCBr.N#CC(C#N)Cc1ccc(C(F)(F)F)cc1>>N#CC(C#N)(CCCCl)Cc1ccc(C(F)(F)F)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20110021479A1,CC(C)OB1OC(C)(C)C(C)(C)O1.COc1cc(Br)c(OCC2CC2)cc1F>>COc1cc(B2OC(C)(C)C(C)(C)O2)c(OCC2CC2)cc1F,,COC(C)(C)C,,[Li]CCCC,,val
US20130116235A1,C[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCc5c(c(F)c6n5CCCC6)C4=O)c3C=O)cn(C)c2=O)nc1>>C[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCc5c(c(F)c6n5CCCC6)C4=O)c3CO)cn(C)c2=O)nc1,,CO,,[BH4-].[Na+],,val
US20110009454A1,N#Cc1ccc(F)cc1.Nc1ncccc1C(=O)NCc1ccc(O)cc1>>N#Cc1ccc(Oc2ccc(CNC(=O)c3cccnc3N)cc2)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20090326074A1,BrCCc1ccccc1.O=Cc1cccc(O)c1>>O=Cc1cccc(OCCc2ccccc2)c1,,CN(C)C=O,,,,val
US04481217,CC(C)=CCC/C(C)=C/CCC(C)CC#N.CC(O)CO.[OH-]>>CC(C)=CCC/C(C)=C/CCC(C)CC(=O)O,,O,,Cl,,val
US20120277224A1,CC(=O)n1nc(C)c2cc(-c3cc(=O)n4nc(N)c(-c5ccccn5)c4[nH]3)ccc21>>Cc1n[nH]c2ccc(-c3cc(=O)n4nc(N)c(-c5ccccn5)c4[nH]3)cc12,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20100119424A1,C=CC(=O)OCC.COC1(I)C=CC(Br)=CC1>>CCOC(=O)C=Cc1cc(Br)ccc1OC,[Pd],Cc1ccccc1,,CCN(CC)CC,,val
US04243819,Cc1ccc([N+](=O)[O-])c(F)c1>>Cc1ccc(N)c(F)c1,O=[Pt],CCO,,[H][H],,val
US20120088791A1,CC(C)(C)OC(=O)N1CCC[C@@H](N)C1.CCOC(=O)N1CCC(=O)CC1.Cc1ccccc1C(=O)Cl>>CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccccc3C)C2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100160424A1,C=CC[C@@H](CCCCl)C(=O)N(C)[C@@H](C)[C@@H](O)c1ccccc1>>C=CC[C@H](CO)CCCCl,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20040142850A1,CCOC(=O)Nc1ccc(Cl)cc1.O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(C(F)(F)F)c1>>CCOC(=O)N(c1ccc(Cl)cc1)c1c([N+](=O)[O-])cc([N+](=O)[O-])cc1C(F)(F)F,,C1CCOC1,,Cl,[H-].[Na+],val
US20090093524A1,COc1ccc(-c2cc3ccc(O)cc3s2)cc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc(-c2cc3ccc(OS(=O)(=O)C(F)(F)F)cc3s2)cc1,,ClCCl,,CCN(CC)CC,,val
US20080004295A1,CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3ccnc-3[nH]2)cc1.Cc1ccc(S(=O)(=O)O)cc1>>CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3ccnc-3[nH]2)cc1.Cc1ccc(S(=O)(=O)O)cc1,,C1CCOC1,,O,,val
US20030105074A1,CCOP([O-])(=S)SCC.COc1ccc(CNc2nnc(N3CCCCC3O)c3ccc(C#N)cc23)cc1Cl>>COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(C(N)=S)cc23)cc1Cl,,O,,CC(C)O,,val
US05508288,Cn1ccc2cc(N)ccc21.Nc1cncc2ccccc12.O=C(n1ccnc1)n1ccnc1>>Cn1ccc2cc(NC(=O)Nc3cncc4ccccc34)ccc21,,CCO,CCOCC,Cl,,val
US20090286775A1,O=C1c2ccc(O)cc2CCN1c1ccccc1Cl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C1c2ccc(OS(=O)(=O)C(F)(F)F)cc2CCN1c1ccccc1Cl,,ClCCl,,c1ccncc1,,val
US20120269831A1,Cn1c(=O)c(S(=O)(=O)c2ccc(Cl)cc2)cc2cnc(S(C)=O)nc21.Nc1ccc(Cl)cc1>>Cn1c(=O)c(S(=O)(=O)c2ccc(Cl)cc2)cc2cnc(Nc3ccc(Cl)cc3)nc21,,Cc1ccccc1,,,,val
US20070049632A1,COC(=O)c1ccccc1Cn1c(=O)c2c(n1C)[C@]1(C)CC[C@H]2C1(C)C>>Cn1c2c(c(=O)n1Cc1ccccc1C(=O)O)[C@H]1CC[C@]2(C)C1(C)C,,C1CCOC1,CO,[Na+].[OH-],,val
US05599814,CO.O=c1[nH]c2cc(I)ccc2c(=O)o1>>COC(=O)c1ccc(I)cc1N,,CO,,O,[Na+].[OH-],val
US05403852,COc1ccc(-c2oc(CCCCCC#N)nc2-c2ccc(Cl)cc2)cc1.[N-]=[N+]=[N-]>>COc1ccc(-c2oc(CCCCCc3nnn[nH]3)nc2-c2ccc(Cl)cc2)cc1,,CN(C)C=O,,[Cl-].[NH4+],,val
US06133292,CC[C@@]1(C)O[C@H](C(C)(C)C)OC1=O.CSc1ccc(Br)cc1>>CC[C@]1(C)O[C@H](C(C)(C)C)OC1(O)c1ccc(SC)cc1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20070249670A1,CC(C)(C)OC(=O)[C@@H](NC(=O)c1ccc(-c2ccccc2)cc1[N+](=O)[O-])C1CCCCC1>>CC(C)(C)OC(=O)[C@@H](NC(=O)c1ccc(-c2ccccc2)cc1N)C1CCCCC1,[Pd],,,,,val
US20150080588A1,COC1(OC)CCOC[C@H]1O.COS(=O)(=O)OC>>CO[C@@H]1COCCC1(OC)OC,,C1CCOC1,ClCCl,O,CC(C)(C)[O-].[K+],val
US04757070,CCC(N)=NO.COCc1c(C(=O)O)ncc2[nH]c3cccc(CN4CCOCC4)c3c12>>CCc1noc(-c2ncc3[nH]c4cccc(CN5CCOCC5)c4c3c2COC)n1,,CN(C)C=O,CN(C)C=O,O=C(n1ccnc1)n1ccnc1,,val
US05135937,N#Cc1ccc(C(c2nc[nH]n2)C2(O)C3CC4CC(C3)CC2C4)cc1>>N#Cc1ccc(C(=C2C3CC4CC(C3)CC2C4)c2nc[nH]n2)cc1,,ClCCl,,O=S(Cl)Cl,,val
US20100029619A1,COC(=O)C(C)(C)c1ccc(C(=O)Nc2cn3c(C)cccc3n2)cc1>>Cc1cccc2nc(NC(=O)c3ccc(C(C)(C)C(=O)O)cc3)cn12,,C1CCOC1,CO,[K+].[OH-],,val
US20140296261A1,CC1(C)OB(c2cccnc2F)OC1(C)C.Clc1ncnc2[nH]ccc12>>Fc1ncccc1-c1ncnc2[nH]ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US05238908,COC(=O)CBr.O=[N+]([O-])c1ccc(F)cc1O>>COC(=O)COc1cc(F)ccc1[N+](=O)[O-],,CCC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090186895A1,COc1cccc(C(=O)Nc2ccc(OCCN)c(-c3ccnn3C)c2)c1.CS(=O)(=O)CCOS(C)(=O)=O>>COc1cccc(C(=O)Nc2ccc(OCCNCCS(C)(=O)=O)c(-c3ccnn3C)c2)c1,,CN(C)C=O,,,,val
US20030134808A1,C=C[C@@]1(OCc2ccccc2)[C@@H](COCc2ccccc2)O[C@@H](n2cc(C)c(=O)[nH]c2=O)[C@@H]1O.CS(=O)(=O)Cl>>C=C[C@@]1(OCc2ccccc2)[C@@H](COCc2ccccc2)O[C@@H](n2cc(C)c(=O)[nH]c2=O)[C@@H]1OS(C)(=O)=O,,c1ccncc1,,,,val
US20120288492A1,COc1cnc(-c2ccc(O)cc2)nc1N1CCOCC1.O=C=Nc1ccccc1>>COc1cnc(-c2ccc(OC(=O)Nc3ccccc3)cc2)nc1N1CCOCC1,,C1COCCO1,,,,val
US20100112090A1,COc1ccc(F)c(F)c1COc1cc([N+](=O)[O-])c(Cl)cc1O.OCCF>>COc1ccc(F)c(F)c1COc1cc([N+](=O)[O-])c(Cl)cc1OCCF,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020037888A1,CCC1(c2cccc(OC)c2)CCCCN(CCN=[N+]=[N-])C1=O.Cl>>CCC1(c2cccc(OC)c2)CCCCN(CCN)C1=O.Cl,[Pd],CO,,,,val
US20080009486A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccc(F)cc1C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12>>Cc1ccc(F)cc1C1NC(=S)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12,,Cc1ccccc1,,,,val
US20070293516A1,IC1CCCC1.Nc1ncnc2[nH]nc(I)c12>>Nc1ncnc2c1c(I)nn2C1CCCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120040020A1,CCS(=O)(=O)N1CCN(c2cnc(N)c(C(=O)O)n2)CC1.CNc1ccccc1N>>CCS(=O)(=O)N1CCN(c2cnc(N)c(-c3nc4ccccc4n3C)n2)CC1,,COCCOC,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20120046306A1,O=C1Cc2ncc(F)cc2N1.O=Cc1cccc(Cl)c1F>>O=C1Nc2cc(F)cnc2/C1=C/c1cccc(Cl)c1F,,CO,,C1CCNCC1,,val
US05298520,Cc1ncc[nH]1.O=[N+]([O-])c1ccc(CBr)cc1>>Cc1nccn1Cc1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20090181963A1,CC(C)(C)OC(=O)N1CCC(n2nnc3c(N4CCOCC4)nc(Cl)nc32)CC1.OB(O)c1cccc(O)c1>>CC(C)(C)OC(=O)N1CCC(n2nnc3c(N4CCOCC4)nc(-c4cccc(O)c4)nc32)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20160229864A1,CC(C)(C)OC(=O)N1CCC2(CC1)CO2.CCCc1cc2c(=O)[nH]cnc2s1>>CCCc1cc2c(=O)n(CC3(O)CCN(C(=O)OC(C)(C)C)CC3)cnc2s1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090012126A1,NCCc1cccc(F)c1.O=C(NCc1cccnc1)c1ccc(Cl)nc1Cl>>O=C(NCc1cccnc1)c1ccc(Cl)nc1NCCc1cccc(F)c1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US03978226,CNC(=O)NC.OC1c2ccccc2Oc2ccccc21>>CNC(=O)N(C)C1c2ccccc2Oc2ccccc21,,CC(=O)O,,Cc1ccccc1,,val
US20120316147A1,CI.COCCOc1nc(C(=O)O)ccc1Br>>COCCOc1nc(C(=O)OC)ccc1Br,,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20100317057A1,CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCCCC(=O)NC[C@@H]1CC[C@@H](C(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)ON2C(=O)CCC2=O)C(=O)OC(C)(C)C)CC1>>O=C(O)CCCCCCCCCCCCCCCCCCC(=O)NC[C@@H]1CC[C@@H](C(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)ON2C(=O)CCC2=O)C(=O)O)CC1,,O=C(O)C(F)(F)F,,,,val
US20130203727A1,C=C[Sn](CCCC)(CCCC)CCCC.CCOC(=O)C(OC(C)(C)C)c1c(C)cc2ccc(Br)cc2c1-c1ccc(Cl)cc1>>C=Cc1ccc2cc(C)c(C(OC(C)(C)C)C(=O)O)c(-c3ccc(Cl)cc3)c2c1,,CC#N,O,CCN(CC)CC,,val
US20070010537A1,CCOC(=O)c1cscc1C.O=[N+]([O-])O>>CCOC(=O)c1csc([N+](=O)[O-])c1C,,CC(=O)O,,,,val
US20080269206A1,C=CC(=O)c1cc(Br)c(OCc2ccc(OC)cc2)c(Br)c1.NN.O=C(Cl)c1ccc(Cl)c(Br)c1>>COc1ccc(COc2c(Br)cc(C3=NN(C(=O)c4ccc(Cl)c(Br)c4)CC3)cc2Br)cc1,,CCO,ClCCl,CCN(CC)CC,O,val
US06908926B1,O=C(O)CCCCC1CCCCC1.c1nc2c([nH]1)CCNC2>>O=C(CCCCC1CCCCC1)N1CCc2[nH]cnc2C1,,ClCCl,,,,val
US07906521B2,CC(C)(C)C(=O)Cl.COc1ccc(C(N)=O)c(Nc2ccccc2)c1>>COc1ccc2c(=O)nc(C(C)(C)C)n(-c3ccccc3)c2c1,,CC(Cl)Cl,,,,val
US20120184562A1,COC(=O)c1cnc(Cl)cc1Cl.NCc1ccccc1>>COC(=O)c1cnc(Cl)cc1NCc1ccccc1,,CN(C)C=O,,CCN(CC)CC,O,val
US20110183938A1,COC(=O)c1c(CN(CC#N)S(=O)(=O)c2ccc(C)cc2)n(S(=O)(=O)c2ccccc2)c2ncc(F)cc12>>N#Cc1ncc2c(c1O)c1cc(F)cnc1n2S(=O)(=O)c1ccccc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20080194654A1,NC1CCCCC1.O=S1(=O)N(CC[C@H]2CO2)c2ccccc2N1c1ccccc1F>>O=S1(=O)N(CC[C@H](O)CNC2CCCCC2)c2ccccc2N1c1ccccc1F,,CO,,,,val
US20040110749A1,CN(C)C=O.O=P(Cl)(Cl)Cl.Oc1cc(C(F)(F)F)nn1-c1ccccc1>>O=Cc1c(C(F)(F)F)nn(-c2ccccc2)c1Cl,,O,,,,val
US20050239857A1,CC(C)(C)OC(=O)C[C@H]1C[C@@H](CCN)OC(C)(C)O1.COC(=O)C(Br)c1ccc(F)cc1>>COC(=O)C(NCC[C@@H]1C[C@H](CC(=O)OC(C)(C)C)OC(C)(C)O1)c1ccc(F)cc1,,CC#N,,CCN(CC)CC,,val
US20030130513A1,BrBr.O=C1CCCc2c(Br)cccc21>>O=C1c2cccc(Br)c2CCC1Br,,CCOCC,ClCCl,,,val
US20120101079A1,CCSc1nc(N2CCC(O)CC2)cc(C)c1C(=O)NCc1cccc(F)c1>>CCSc1nc(N2CCC(=O)CC2)cc(C)c1C(=O)NCc1cccc(F)c1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20150051394A1,CS(=O)(=O)Cl.OC[C@@]12COC(c3ccccc3)OC[C@@H]1C2>>CS(=O)(=O)OC[C@@]12COC(c3ccccc3)OC[C@@H]1C2,,ClCCl,,CCN(CC)CC,O,val
US20030212049A1,CC#CCOc1ccc(S(=O)(=O)N(C)C(C(=O)NO)c2ccc(OCCCNC(=O)OC(C)(C)C)cc2)cc1>>CC#CCOc1ccc(S(=O)(=O)N(C)C(C(=O)NO)c2ccc(OCCCN)cc2)cc1,,ClCCl,,Cl,,val
US20130085157A1,COc1ccc(C(=O)c2sc3nnc(S)n3c2-c2ccccc2)cc1OC.Fc1cccc(Cl)c1CBr>>COc1ccc(C(=O)c2sc3nnc(SCc4c(F)cccc4Cl)n3c2-c2ccccc2)cc1OC,,ClCCl,,CCN(CC)CC,,val
US20030004181A1,COC(=O)CCNc1ccccc1.COCc1nc2sc(C(=O)O)cc2n1C>>COCc1nc2sc(C(=O)N(CCC(=O)OC)c3ccccc3)cc2n1C,,C1CCOC1,ClCCl,CCN(CC)CC,O=S(Cl)Cl,val
US20040097731A1,CCOC(=O)N1CCN(c2ccc(C(O)c3ccc(Nc4ccc(F)cc4F)nc3)c(Cl)c2)CC1>>CCOC(=O)N1CCN(c2ccc(C(=O)c3ccc(Nc4ccc(F)cc4F)nc3)c(Cl)c2)CC1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20150141406A1,CCN=C=NCCCN(C)C.O=C(O)c1cc(-c2nn(C3CCOCC3)c3cc[nH]c(=O)c23)cs1>>NC(=O)c1cc(-c2nn(C3CCOCC3)c3cc[nH]c(=O)c23)cs1,,CN(C)C=O,,Cl,O,val
US20050282862A1,CC(C)N1CCC(C(=O)Nc2ccc(I)cc2C(=O)Nc2ccc(Cl)cn2)CC1.CN(C)C=O.CO>>COC(=O)c1ccc(NC(=O)C2CCN(C(C)C)CC2)c(C(=O)Nc2ccc(Cl)cn2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,CCN(CC)CC,,val
US20030100563A1,O=C(O)c1cc(F)c(Br)cc1F>>OCc1cc(F)c(Br)cc1F,,C1CCOC1,,CO,,val
US20090181965A1,BrBr.CCCC1(c2cccc(OC)c2)CCCCC1=O>>CCCC1(c2cccc(OC)c2)CCCC(Br)C1=O,,ClC(Cl)Cl,,,,val
US20060046999A1,C#CC(=O)OC.COc1cccc(NC(=N)CC(=O)c2ccccc2)c1>>COc1cccc(-n2c(N)c(C(=O)c3ccccc3)ccc2=O)c1,,CO,,,,val
US05665718,CCCNCCC.O=C1c2ccccc2-n2cnc(-c3nnc(CCl)o3)c2[C@@H]2CCN12>>CCCN(CCC)Cc1nnc(-c2ncn3c2[C@@H]2CCN2C(=O)c2ccccc2-3)o1,,CN(C)C=O,,,,val
US20020049217A1,N#Cc1ccc(C(O)c2cccnc2)cc1F>>N#Cc1ccc(C(=O)c2cccnc2)cc1F,O=[Mn]=O,ClCCl,,,,val
US20100152207A1,CI.Cc1cccc(OCCCC(=O)OC(C)(C)C)c1NC(=O)c1ccc(Cl)c(Br)c1>>Cc1cccc(OCCCC(=O)OC(C)(C)C)c1N(C)C(=O)c1ccc(Cl)c(Br)c1,,CN(C)C=O,,O,[H-].[Na+],val
US06136823,CN.COc1c(F)c(F)cc2c(=O)c(C(=O)O)cn(-c3cc(N)c(F)cc3F)c12>>CNc1c(F)cc2c(=O)c(C(=O)O)cn(-c3cc(N)c(F)cc3F)c2c1OC,,c1ccncc1,,,,val
US04086350,O=C(O)c1ccc(Cl)cc1I.Oc1ccc(F)cc1>>O=C(O)c1ccc(Cl)cc1Oc1ccc(F)cc1,,c1ccncc1,,O=C([O-])[O-].[K+].[K+],,val
US09315475B2,COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H]1CN(C(=O)OC(C)(C)C)[C@H](CN)CO1)C(c1ccccc1)c1ccccc1.O=C=Nc1ccccc1>>COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H]1CN(C(=O)OC(C)(C)C)[C@H](CNC(=O)Nc2ccccc2)CO1)C(c1ccccc1)c1ccccc1,,ClCCl,,,,val
US20120059030A1,CCOC(=O)Cc1ccc(F)c(F)c1.CCOC(=O)OCC>>CCOC(=O)C(C(=O)OCC)c1ccc(F)c(F)c1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20060211698A1,Br.Cc1cc(N)ccc1[N+](=O)[O-]>>Cc1cc(Br)ccc1[N+](=O)[O-],,CC(C)=O,O,O=N[O-].[Na+],,val
US04837333,CCOC(=O)c1cccc(CCBr)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1cccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1.[Br-],,Cc1ccccc1,,,,val
US20130072677A1,CCOC(=O)[C@](C)(NC)C(=O)NC.O=C(Cl)c1ccc(I)cc1>>CCOC(=O)C(C)(C(=O)NC)N(C)C(=O)c1ccc(I)cc1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20030119842A1,CC(=O)Cl.Nc1ncccn1.O=Cc1ccccn1.[C-]#[N+]C1CCCCC1>>CC(=O)[n+]1c(-c2ccccn2)c(NC2CCCCC2)n2cccnc21.[Cl-],,[O-][Cl+3]([O-])([O-])O,,,,val
US20120046306A1,COc1cc(C#N)ccc1NC(=O)C1NC(CC(C)(C)C)C2(C(=O)Nc3cc(Cl)sc32)C1c1cccc(Cl)c1F.OO>>COc1cc(C(N)=O)ccc1NC(=O)C1NC(CC(C)(C)C)C2(C(=O)Nc3cc(Cl)sc32)C1c1cccc(Cl)c1F,,CS(C)=O,,[Na+].[OH-],,val
US20130059853A1,CC(C)(CO)CBr.CCOc1ccc(-c2ccc3c(c2)COC3=O)c(O)c1OC>>CCOc1ccc(-c2ccc3c(c2)COC3=O)c(OCC(C)(C)CO)c1OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04259506,CNC.O=C=Nc1coc2ccccc2c1=O>>CN(C)C(=O)Nc1coc2ccccc2c1=O,,Cc1ccccc1,,,,val
US20100249087A1,CC(C)(C)OC(=O)NNC(=O)OC(C)(C)C.OCC1CC1>>CC(C)(C)OC(=O)NN(CC1CC1)C(=O)OC(C)(C)C,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040204386A1,CCOC(=O)CC(=O)OCC.O=[N+]([O-])c1ccc(Br)cc1>>CCOC(=O)C(C(=O)OCC)c1ccc([N+](=O)[O-])cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20140005213A1,COCCBr.Cc1ccc2ccc(O)c(Cl)c2n1>>COCCOc1ccc2ccc(C)nc2c1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080287396A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12>>COc1c(N2CCN(C(=O)OC(C)(C)C)C(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,,C1CCOC1,,[Na+].[OH-],,val
US20030027964A1,C=C(C)C(=O)OC(=O)C(=C)C.Nc1ccc(C(=O)O)c(O)c1>>C=C(C)C(=O)Nc1ccc(C(=O)O)c(O)c1,,CC(C)=O,,,,val
US20040204406A1,CCOC(=O)c1cc(OCCOCCOC)n[nH]1.O=C(CBr)Nc1ccc(Cl)cn1>>CCOC(=O)c1cc(OCCOCCOC)nn1CC(=O)Nc1ccc(Cl)cn1,,CN(C)C=O,,O,[H-].[Na+],val
US20160009667A1,CS(=O)(=O)Cl.Nc1noc2cc(COC3CCC(F)(F)CC3)c(Cl)cc12>>CS(=O)(=O)Nc1noc2cc(COC3CCC(F)(F)CC3)c(Cl)cc12,,ClCCl,,CCN(CC)CC,,val
US20020086890A1,CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCNCC2)cc1.O=C(Cl)c1ccccc1>>CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCN(C(=O)c3ccccc3)CC2)cc1,,ClC(Cl)Cl,,CCN(CC)CC,CN(C)c1ccccn1,val
US20150038437A1,CCc1cc(C(=O)OC)c(=O)n(Cc2ccc(OC)cc2OC)c1-c1ccc2c(c1)cc1n2CCC1O[Si](C)(C)C(C)(C)C>>CCc1cc(C(=O)OC)c(=O)n(Cc2ccc(OC)cc2OC)c1-c1ccc2c(c1)cc1n2CCC1O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110190263A1,CC(OC1CN(C(=O)OC(C)(C)C)C1)C1CCN(Cc2ccccc2)CC1>>CC(OC1CN(C(=O)OC(C)(C)C)C1)C1CCNCC1,[Pd],CCO,CCOC(C)=O,,,val
US20060166997A1,CC(=O)O.CC(C)(C)OC(=O)n1cccc1-c1cccc([N+](=O)[O-])c1>>CC(=O)Nc1cccc(C2CCCN2C(=O)OC(C)(C)C)c1,[Pt],CCO,,,,val
US20110028467A1,O=C(c1cc(OCc2ccccc2)no1)N1CCOc2ccncc21>>O=C(c1cc(O)no1)N1CCOc2ccncc21,,Br,CC(=O)O,O,O=C([O-])O.[Na+],val
US20080139561A1,CC(C)Oc1cc(N)n[nH]1.N#Cc1cc(F)c(Cl)nc1Cl>>CC(C)Oc1cc(Nc2nc(Cl)c(C#N)cc2F)n[nH]1,,C1CCOC1,,CCN(CC)CC,,val
US20110046133A1,Cc1cc(OCCN2CCCC2)cc(C)c1C=O.Cc1ccc(NC(=O)c2ccc(N)c(N)c2)cc1C>>Cc1ccc(NC(=O)c2ccc3nc(-c4c(C)cc(OCCN5CCCC5)cc4C)[nH]c3c2)cc1C,,CO,,,,val
US20140018313A1,CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2ccc3c(c2)C(F)(F)c2cc(-c4ccc5nc([C@@H]6CC7(CN6C(=O)OCc6ccccc6)OCCO7)[nH]c5c4)ccc2-3)[nH]1>>CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2ccc3c(c2)C(F)(F)c2cc(-c4ccc5nc([C@@H]6CC7(CN6)OCCO7)[nH]c5c4)ccc2-3)[nH]1,[Pd],CCOC(C)=O,,CCN(CC)CC,,val
US20120190665A1,CCOC(=O)C(=CN(C)C)C(=O)c1cc(Cl)ccc1OC1CC1.NN>>CCOC(=O)c1c[nH]nc1-c1cc(Cl)ccc1OC1CC1,,CC(=O)O,O,,,val
US07553965B2,COc1cc2c3c(c1OC)C(=O)CC3N(CCCCN)CC2.Cl.O=S(=O)(Cl)c1ccccc1Cl>>COc1cc2c3c(c1OC)C(=O)CC3N(CCCCNS(=O)(=O)c1ccccc1Cl)CC2.Cl,,ClCCl,,Cl,,val
US20040229858A1,CCOC(=O)c1ccc(/C=C/C2CCCN2C(=O)OC(C)(C)C)cc1>>CCOC(=O)c1ccc(/C=C/C2CCCN2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120225867A1,CC(=O)c1cc(C(=O)N[C@@H](C)Cn2ccc(-c3cc(F)c(C#N)c(Cl)c3)n2)[nH]n1>>CC(O)c1cc(C(=O)N[C@@H](C)Cn2ccc(-c3cc(F)c(C#N)c(Cl)c3)n2)[nH]n1,,CCO,,Cl,[BH4-].[Na+],val
US20110251173A1,Cc1nc(Cl)c(C=O)c(Cl)n1.O=S(=O)(Cl)Cl>>Cc1nc(Cl)c(C(=O)Cl)c(Cl)n1,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,,,val
US20110003806A1,C=CCn1ccnc1-c1sc(-c2ncnc3sc(N)nc23)cc1-c1ccc(Cl)cc1Cl.CC(=O)Cl>>C=CCn1ccnc1-c1sc(-c2ncnc3sc(NC(C)=O)nc23)cc1-c1ccc(Cl)cc1Cl,,c1ccncc1,,,,val
US20120172345A1,CCOC(=O)c1sc(-c2ccncc2)nc1Cc1ccc(Cl)cc1.O=C(OO)c1cccc(Cl)c1>>COC(=O)c1sc(-c2cc[n+]([O-])cc2)nc1Cc1ccc(Cl)cc1,,CN(C)C=O,,ClCCl,O=C([O-])O.[Na+],val
US20110218201A1,CC(C)I.COc1ccc(C2=NN(C3CCN(C(=O)c4cc(O)ccc4C)CC3)C(=O)C2(C)C)cc1OC>>COc1ccc(C2=NN(C3CCN(C(=O)c4cc(OC(C)C)ccc4C)CC3)C(=O)C2(C)C)cc1OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05344843,COC(=O)C(=O)c1ccc(OCCOc2ccnc3ccccc23)cc1>>O=C(O)C(=O)c1ccc(OCCOc2ccnc3ccccc23)cc1,,CO,O,[Na+].[OH-],,val
US04039543,COC(=O)c1cc(N(C)C)cc(N(C)C)c1.CS(C)(=O)=O>>CN(C)c1cc(C(=O)CS(C)(=O)=O)cc(N(C)C)c1,,CS(C)=O,,[H-].[Na+],,val
US20130267546A1,CI.COCOCCCCCCCCCCc1nc(N)cc(C)c1OCc1ccccc1.O=N[O-]>>COCOCCCCCCCCCCc1nc(OC)cc(C)c1OCc1ccccc1,,O,,[Na+].[OH-],,val
US05015758,CC(=O)OC12CC3CC(CC(C3)C1)C2.COC(=O)c1ccc(OC)cc1>>COC(=O)c1ccc(OC)c(C23CC4CC(CC(C4)C2)C3)c1,,CCCCCCC,,O=S(=O)(O)O,,val
US05310735,COc1ccc(CS[C@H]2C[C@@H](C(=O)N3CCCN(CCOC(N)=O)CC3)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1.O=S(=O)(O)C(F)(F)F>>NC(=O)OCCN1CCCN(C(=O)[C@@H]2C[C@H](S)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)CC1.O=S(=O)(O)C(F)(F)F,,COc1ccccc1,,O=C(O)C(F)(F)F,,val
US20140315911A1,CC(C)CCN1c2nc(Cl)ncc2NC(=O)C1C.OB(O)c1ccccc1>>CC(C)CCN1c2nc(Cl)ncc2N(c2ccccc2)C(=O)C1C,,ClCCl,,CCN(CC)CC,,val
US20160221972A1,COC(=O)c1ccc2c(c1)OCCN(c1ccccc1)C2.NO>>O=C(NO)c1ccc2c(c1)OCCN(c1ccccc1)C2,,C1CCOC1,,[Na+].[OH-],,val
US20130217666A1,C#C[Mg]Br.CC(C)(C)OC(=O)N1C2CCC1CC(=O)C2>>C#CC1(O)CC2CCC(C1)N2C(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20160031899A1,C[C@]1([C@H]2CC[C@@]3(C)[C@@H](CC[C@@]3(O)c3cccs3)[C@@H]2CN)CC[C@H](O)C[C@@H]1CO>>C[C@]12CC[C@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)[C@@H](CN)[C@@H]1CC=C2c1cccs1,,CCO,Cc1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20080200542A1,C=CC=O.CCOC(=O)CNC(=O)c1ccc(F)cc1C(F)(F)F>>C=CC(O)C(NC(=O)c1ccc(F)cc1C(F)(F)F)C(=O)OCC,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20120208799A1,Nc1cccc(Br)c1C(=O)O.O=C(Cl)CCl>>O=C(CCl)Nc1cccc(Br)c1C(=O)O,,Cc1ccccc1,,c1ccncc1,,val
US05011932,CC(=O)c1ccncc1.NNC(=O)C1CCC1>>CC(=NNC(=O)C1CCC1)c1ccncc1,,CCO,,,,val
US04699652,CCC(=O)C(O)(Cc1ccc(Cl)cc1Cl)c1cccnc1.OCCO>>CC1(CC(O)(Cc2ccc(Cl)cc2Cl)c2cccnc2)OCCO1,,Cc1ccccc1,O,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20070078133A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1nc2cc(Br)ccc2s1>>Cc1nc2cc(B3OC(C)(C)C(C)(C)O3)ccc2s1,,C1CCOC1,,CC(=O)[O-].[K+],,val
US20150291597A1,CCCN.Clc1cc(Cl)nc(Cl)n1>>CCCNc1cc(Cl)nc(Cl)n1,,CCO,,,,val
US04820727,CCOC(=O)N(CC(=O)OC(C)(C)C)C(=O)c1c(F)ccc2c(C(F)(F)F)c(OC)ccc12>>CCOC(=O)N(CC(=O)O)C(=O)c1c(F)ccc2c(C(F)(F)F)c(OC)ccc12,,O,O=CO,,,val
US04762830,CCOC(=O)C1C(=O)N(C)C(=O)N(C)C1=O.COc1cc(N)ccc1O>>COc1cc(NC(=O)C2C(=O)N(C)C(=O)N(C)C2=O)ccc1O,,Cc1ccccc1,,CCO,,val
US20110021556A1,O=C1CC(Cc2ccccc2)(c2ccc3[nH]ccc3c2)C(=O)N1Cc1ccccc1>>c1ccc(CN2CCC(Cc3ccccc3)(c3ccc4[nH]ccc4c3)C2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04670447,Clc1ccc2c(C3CCNCC3)n[nH]c2c1.N#CBr>>N#CN1CCC(c2n[nH]c3cc(Cl)ccc23)CC1,,CS(C)=O,,O,O=C([O-])O.[Na+],val
US20090258854A1,O=S(Cl)Cl.OCc1ccc(Oc2nc3cccnc3s2)cc1>>ClCc1ccc(Oc2nc3cccnc3s2)cc1,,ClCCl,,,,val
US20150225405A1,Cc1nc(Cl)ccc1Br.O[C@H]1CCNC1>>Cc1nc(N2CC[C@H](O)C2)ccc1Br,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20090069299A1,CC(C)(C)OC(=O)N1CCC(CC=O)CC1.O=c1c2c([nH]n1-c1ccccc1)CNc1ccccc1-2>>CC(C)(C)OC(=O)N1CCC(CC(O)c2c3c(nn2-c2ccccc2)c(=O)[nH]c2ccccc23)CC1,,CC#N,,C1CCOC1,[Li]CCCC,val
US20030144282A1,COC(=O)c1cccc(-c2ccc(S(=O)(=O)CCc3c(CCOS(C)(=O)=O)n(C(c4ccccc4)c4ccccc4)c4ccc(Cl)cc34)cc2)c1.[N-]=[N+]=[N-]>>COC(=O)c1cccc(-c2ccc(S(=O)(=O)CCc3c(CCN=[N+]=[N-])n(C(c4ccccc4)c4ccccc4)c4ccc(Cl)cc34)cc2)c1,,O,,CN(C)C=O,,val
US20100311777A1,COC(=O)C1(NC(=O)Cc2cc(Br)c(F)cc2C)CCN(OC)CC1>>CON1CCC2(CC1)NC(=O)C(c1cc(Br)c(F)cc1C)=C2O,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20120088755A1,Clc1cc(Oc2cc(Cl)c3[nH]c(C4CCOC4)nc3c2)ncn1.O=C1Nc2ncccc2C2(CCNCC2)O1>>O=C1Nc2ncccc2C2(CCN(c3cc(Oc4cc(Cl)c5[nH]c(C6CCOC6)nc5c4)ncn3)CC2)O1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20130131016A1,CC(C)c1cccc(C(C)C)c1N.O=Cc1ccccn1>>CC(C)c1cccc(C(C)C)c1N=Cc1ccccn1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050020830A1,CN(C)C=C1C(=O)C2CC1CN(Cc1ccccc1)C2.NNc1ccc(F)cc1>>Fc1ccc(-n2ncc3c2C2CC3CN(Cc3ccccc3)C2)cc1,,CCO,,Cl,,val
US20110009438A1,CCSCC(=O)O.CNCc1ccc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)cc1Cl>>CCSCC(=O)N(C)Cc1ccc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)cc1Cl,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20080139572A1,CC(C)(C)C(=O)Nc1nc[nH]n1.COc1cnc(Br)c2[nH]ccc12>>COc1cnc(-n2cnc(NC(=O)C(C)(C)C)n2)c2[nH]ccc12,[Cu]I,C1COCCO1,,CN[C@@H]1CCCC[C@H]1NC,O=C([O-])[O-].[K+].[K+],val
US20100234365A1,CS(=O)(=O)Cl.NC[C@@H]1OC(=O)N(c2ccc(Oc3ccc(Cl)cc3)cc2)[C@H]1c1ccccc1>>CS(=O)(=O)NC[C@@H]1OC(=O)N(c2ccc(Oc3ccc(Cl)cc3)cc2)[C@H]1c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20090137595A1,CC(=O)Nc1cn2nc(Oc3cccc(N)c3)ccc2n1.O=C(Cl)C1CC1>>CC(=O)Nc1cn2nc(Oc3cccc(NC(=O)C4CC4)c3)ccc2n1,,CC(=O)N(C)C,,,,val
US05250547,CC1(C)Oc2ccc([N+](=O)[O-])cc2C=C1CBr.NC(=O)C(F)(F)F>>CC1(C)Oc2ccc([N+](=O)[O-])cc2C=C1CNC(=O)C(F)(F)F,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20080306112A1,CC(C)(C)OC(=O)N1CCC(n2c(=O)[nH]c3ccc(Cl)cc32)CC1.Cl>>Cl.O=c1[nH]c2ccc(Cl)cc2n1C1CCNCC1,,CCO,,,,val
US20140031349A1,CCOC(=O)C1(CC#N)CCN(Cc2ccccc2)CC1=O>>CCOC(=O)C1(CCN)CCN(Cc2ccccc2)CC1O,O=[Pt],CC(=O)O,CO,,,val
US05981533,CSC(=S)c1cccc([N+](=O)[O-])c1.N#CC1(C#N)OC1(C#N)C#N>>CSC(=C(C#N)C#N)c1cccc([N+](=O)[O-])c1,,Cc1ccccc1,,,,val
US20120142717A1,CCc1c[nH]c(OCCc2ccc(Oc3cc(Cl)cc(C(F)(F)F)c3)cc2)nc1=O.CI>>CCc1cn(C)c(OCCc2ccc(Oc3cc(Cl)cc(C(F)(F)F)c3)cc2)nc1=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140051654A1,CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21)C1CC(CCC(=O)OCc2ccccc2)C1>>CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21)C1CC(CCC(=O)O)C1,[Pd],CCO,,,,val
US06214873B1,CC(=O)NC(CCc1ccc(C(=O)CCCCc2ccccc2)cc1)(CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C>>CC(=O)NC(CO)(CO)CCc1ccc(C(=O)CCCCc2ccccc2)cc1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20120028964A1,CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)c3ccc(Cl)cc3)cc2)C1.Cl>>Cl.O=C(Nc1ccc(C2CCNC2)cc1)c1ccc(Cl)cc1,,C1CCOC1,C1COCCO1,,,val
US20150344437A1,CN(C)S(=O)(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cn1nc(C(C)(C)C)c(Br)c1OC(=O)c1ccccc1>>CN1N=C(C(C)(C)C)C(c2ccc(S(=O)(=O)N(C)C)cc2)C1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])O.[Na+],,val
US03993772,Cc1occc1C(=O)Cl.ONC1CCCC1>>Cc1occc1C(=O)N(O)C1CCCC1,,c1ccccc1,,CCN(CC)CC,Cl,val
US20100179312A1,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)C[C@@H]1O>>OC[C@H]1O[C@@H](n2cnc3c(On4nnc5ccccc54)ncnc32)C[C@@H]1O,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05783593,CC[C@@H](C)N.O=Cc1ccc(Oc2ccccc2)cc1>>CC[C@@H](C)NCc1ccc(Oc2ccccc2)cc1,,CO,,[BH3-]C#N.[Na+],,val
US05166214,CCCCCCCNCCC(C)(C)CCO.O=C=Nc1ccc(F)cc1F>>CCCCCCCN(CCC(C)(C)CCO)C(=O)Nc1ccc(F)cc1F,,ClCCl,,,,val
US20120065196A1,CCOC(=O)C1CCC(=O)C(Br)C1.Cc1nc(C(N)=S)c[nH]1>>CCOC(=O)C1CCc2nc(-c3c[nH]c(C)n3)sc2C1,,CCO,,,,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4c(C)nc5ccccn45)cc2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4c(C)nc5ccccn45)cc2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20100041681A1,CCOC(=O)CCNC(=O)OCC.CCOC(=O)Cl.ClCCl>>CCOC(=O)CCN(CC(=O)OCC)C(=O)OCC,,ClCCl,,CCN(CC)CC,,val
US20100069394A1,CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccc(Cl)s3)c(C(F)(F)F)nn2)CC1>>FC(F)(F)c1nnc(N2CCNCC2)cc1-c1ccc(Cl)s1,,CO,,,,val
US20020049204A1,CC1(C)OC(=O)Nc2ccc(-c3ccc[nH]3)cc21.CI>>Cn1cccc1-c1ccc2c(c1)C(C)(C)OC(=O)N2,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060052377A1,BrC(Br)(Br)Br.O[C@@H](c1ccc(Cl)cc1)[C@@H]1CN(Cc2ccccc2)CCO1.O[C@H](c1ccc(Cl)cc1)[C@H]1CN(Cc2ccccc2)CCO1>>Clc1ccc([C@@H](Br)[C@@H]2CN(Cc3ccccc3)CCO2)cc1.Clc1ccc([C@H](Br)[C@H]2CN(Cc3ccccc3)CCO2)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20140038060A1,CS(=O)(=O)Cl.Oc1ccccc1C(F)(F)F>>CS(=O)(=O)Oc1ccccc1C(F)(F)F,,CCOC(C)=O,,,,val
US20130005689A1,CC(C)(C)Oc1cc(-c2ccc(CNC(=O)c3c(Cl)cccc3Cl)cc2)ccn1>>O=C(NCc1ccc(-c2cc[nH]c(=O)c2)cc1)c1c(Cl)cccc1Cl,,O=CO,,,,val
US20160023991A1,CCOC(=O)CCCCCOc1ccccc1CNC(=O)c1ccc(-c2ccco2)cc1>>O=C(O)CCCCCOc1ccccc1CNC(=O)c1ccc(-c2ccco2)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20110092558A1,CC(N)CCCc1c(Cl)cc(Cl)cc1Cl.Cn1cc(C(=O)O)c(C(F)F)n1>>CC(CCCc1c(Cl)cc(Cl)cc1Cl)NC(=O)c1cn(C)nc1C(F)F,,O,c1ccncc1,,,val
US04609651,Brc1ccc(Br)cc1.C[Si](C)(C)Cl>>C[Si](C)(C)c1ccc(Br)cc1,,CCCCCC,CCOCC,[Li]CCCC,,val
US20020120007A1,BrCc1ccccc1.Cc1ccc([N+](=O)[O-])cc1O>>Cc1ccc([N+](=O)[O-])cc1OCc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20160083387A1,BrCc1ccccc1.C=C1CC[C@H]2[C@H](CO)[C@@H]([C@@]3(C)CC[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]3CO[Si](C)(C)C(C)(C)C)CC[C@]12C>>C=C1CC[C@H]2[C@H](COCc3ccccc3)[C@@H]([C@@]3(C)CC[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]3CO[Si](C)(C)C(C)(C)C)CC[C@]12C,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20150152131A1,CON.C[C@]1(OCc2ccccc2)[C@@H](O)O[C@H](COCc2ccccc2)[C@H]1OCc1ccccc1>>CON=C[C@](C)(OCc1ccccc1)[C@H](OCc1ccccc1)[C@H](O)COCc1ccccc1,,CCN(CC)CC,,CO,Cl,val
US20010051657A1,COc1ccc(Oc2c(C)cc([N+](=O)[O-])cc2C)cc1C(C)C>>Cc1cc([N+](=O)[O-])cc(C)c1Oc1ccc(O)c(C(C)C)c1,,ClCCl,,BrB(Br)Br,,val
US06248739B1,CCOC(=O)c1cn(C2CC2)c2ccc(CN3CCOCC3)cc2c1=O.NCc1ccc(Cl)cc1>>O=C(NCc1ccc(Cl)cc1)c1cn(C2CC2)c2ccc(CN3CCOCC3)cc2c1=O,,ClCCl,,CCOCC,,val
US04948809,CC(=O)Cl.CCC(=O)c1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1>>CCC(=O)c1ccc(CCN(C(C)=O)S(=O)(=O)c2ccc(Cl)cc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20090023731A1,Nc1cccc(OCCCN2CCOCC2)c1.O=C=Nc1c(F)c(F)c(F)c(F)c1F>>O=C(Nc1cccc(OCCCN2CCOCC2)c1)Nc1c(F)c(F)c(F)c(F)c1F,,ClC(Cl)Cl,,,,val
US05741790,C1COCCN1.CS(=O)(=O)OC1CN(C(c2ccccc2)c2ccccc2)C1>>c1ccc(C(c2ccccc2)N2CC(N3CCOCC3)C2)cc1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US04399134,CSc1c(C)[nH]c2c(Br)cc(F)c(N3CCOCC3)c12>>Cc1cc2c(N3CCOCC3)c(F)cc(Br)c2[nH]1,[Ni],C1COCCO1,,,,val
US05872115,NCC1CCN(C(c2ccccc2)c2ccccc2)CC1.O=c1[nH]c2cc(Cl)ccc2c(=O)o1>>Nc1cc(Cl)ccc1C(=O)NCC1CCN(C(c2ccccc2)c2ccccc2)CC1,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,,,val
US05849710,Cl.O=C1Nc2ccc(C(=O)CN3CCCCC3)cc2C1=Cc1c[nH]c2ccccc12>>Cl.O=C1Nc2ccc(C(=O)CN3CCCCC3)cc2C1=Cc1c[nH]c2ccccc12,,O,,,,val
US20010041802A1,O=c1oc2cccc(OC(F)F)c2c2ccc([N+](=O)[O-])cc12>>Nc1ccc2c(c1)c(=O)oc1cccc(OC(F)F)c12,[Pd],C1COCCO1,,,,val
US20090247567A1,COC(=O)c1cc2c(s1)-c1cc(Br)ccc1OC2>>O=C(O)c1cc2c(s1)-c1cc(Br)ccc1OC2,,C1CCOC1,O,[K+].[OH-],,val
US04239759,CC(=O)Cl.CC(CCN)c1ccc(-c2ccc(Cl)cc2)cc1>>CC(=O)NCCC(C)c1ccc(-c2ccc(Cl)cc2)cc1,,O,,c1ccncc1,,val
US20140275071A1,C[Si](C)(C)CCOCn1c(=O)n(CCCOC2CCCCO2)c(=O)c2c1nc(Cl)n2Cc1ccccc1>>O=c1[nH]c2nc(Cl)n(Cc3ccccc3)c2c(=O)n1CCCO,,CCO,,Cl,,val
US04101667,O=C(O)c1cccc2c1CC(=O)c1cccc(F)c1S2>>O=C(O)c1cccc2c1CCc1cccc(O)c1S2,,C1COCCO1,CCO,NN,O,val
US05208240,CCCn1c(=O)c2nc(C(CC)c3ccc(SCC(=O)O)cc3)[nH]c2n(CCC)c1=O.CO>>CCCn1c(=O)c2nc(C(CC)c3ccc(SCC(=O)OC)cc3)[nH]c2n(CCC)c1=O,,CCOCC,,O=S(=O)(O)O,,val
US20140228405A1,CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(N)cc1.O=C(Cl)OCC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(NC(=O)OCC(Cl)(Cl)Cl)cc1,,C1CCOC1,,CCN(CC)CC,[Cl-].[NH4+],val
US20030114469A1,C1COCCN1.CCOC(=O)Cc1cnc(Cl)c2cc(OC)c(OC)cc12>>CCOC(=O)Cc1cnc(N2CCOCC2)c2cc(OC)c(OC)cc12,,Cc1ccccc1,,,,val
US20140243302A1,CCOC(=O)CC(=O)Cl.CNc1cccc(Cl)c1>>CCOC(=O)CC(=O)N(C)c1cccc(Cl)c1,,ClCCl,,CCN(CC)CC,,val
US03974158,O=C(Cl)Oc1ccccc1.c1ccc(CN2CCOC(CNc3ccccc3)C2)cc1>>Cl.O=C(Oc1ccccc1)N(CC1CN(Cc2ccccc2)CCO1)c1ccccc1,,Cc1ccccc1,,,,val
US20090075996A1,CC(=O)C(C)Cl.NC(=S)c1cccc(N)c1>>Cc1nc(-c2cccc(N)c2)sc1C,,CCO,CCOC(C)=O,,,val
US20100305122A1,CCOC(=O)C1CCC(N(C2CC2)C2COC2)CC1>>OCC1CCC(N(C2CC2)C2COC2)CC1,,C1CCOC1,CCOC(C)=O,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20020137750A1,CCCC(=O)Nc1ccc(O)c(C(C)=O)c1.CN(C)C=O>>CCCC(=O)Nc1ccc(OC)c(C(C)=O)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160096839A1,C=CC[C@H](NC(=O)OC(C)(C)C)c1cc(F)cc(-c2c([N+](=O)[O-])cnn2C)c1>>C=CC[C@H](NC(=O)OC(C)(C)C)c1cc(F)cc(-c2c(N)cnn2C)c1,[Zn],CC(C)=O,O,[Cl-].[NH4+],,val
US20120082646A1,CCOC(=O)CN=C=O.COc1c(I)cc(N)cc1C(C)(C)C>>CCOC(=O)CNC(=O)Nc1cc(I)c(OC)c(C(C)(C)C)c1,,C1COCCO1,,,,val
US20030229072A1,C=CC(=O)OC.CCCCC[N+](=O)[O-]>>COC(=O)CCC1([N+](=O)[O-])CCCC1,,C1COCCO1,,,,val
US20140194418A1,CSc1nc(Cl)c(C(N)=O)c(Nc2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)c(C)c2)n1.NN>>CSc1nc(NN)c(C(N)=O)c(Nc2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)c(C)c2)n1,,C1COCCO1,,O,,val
US04340598,COC(=O)Cc1cnc(-c2ccccc2)n1Cc1ccccc1.O=[N+]([O-])O>>COC(=O)Cc1cnc(-c2ccccc2)n1Cc1ccc([N+](=O)[O-])cc1,,CC(=O)O,,O=C([O-])O.[Na+],,val
US03987039,CON=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)Cc3cccs3)[C@H]2SC1>>CON=CC1=C(C(=O)O)N2C(=O)C(NC(=O)Cc3cccs3)[C@H]2SC1,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20140349972A1,CCOP(C)(=O)c1ccc([C@@H](NC(=O)c2cnc(-n3cccn3)nc2O)c2ccc(F)cc2F)cc1>>CP(=O)(O)c1ccc([C@@H](NC(=O)c2cnc(-n3cccn3)nc2O)c2ccc(F)cc2F)cc1,,C1COCCO1,,[Na+].[OH-],,val
US20070037828A1,ClCl.Cl[Fe](Cl)Cl.O=c1ccnc[nH]1>>O=C1[NH2+]C=NC=C1Cl.[Cl-],Cl[Fe](Cl)Cl,CC(=O)O,,,,val
US20070015790A1,BrC(Br)(Br)Br.CCOP(=O)(OCC)Oc1ccc(CO)cc1>>CCOP(=O)(OCC)Oc1ccc(CBr)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090176823A1,COC(=O)C1=C(c2ccc(OCc3cc(-c4c(F)ccc(F)c4Cl)no3)cc2)CCN(C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N1CCC(c2ccc(OCc3cc(-c4c(F)ccc(F)c4Cl)no3)cc2)=C(C(=O)O)C1,,C1CCOC1,,Cl,[Li+].[OH-],val
US05968962,CC(=O)OC(C)=O.CC1(c2ccc(N3C[C@@H](CN)OC3=O)cc2F)CN(C(=O)OCc2ccccc2)C1.c1ccncc1>>CC(=O)NC[C@H]1CN(c2ccc(C3(C)CN(C(=O)OCc4ccccc4)C3)c(F)c2)C(=O)O1.CC(N)=O,,ClCCl,,,,val
US20110028455A1,CCc1ncc(C#N)c(Nc2ccc3[nH]ccc3c2C)c1I.COc1ccc(B(O)O)cc1OC>>CCc1ncc(C#N)c(Nc2ccc3[nH]ccc3c2C)c1-c1ccc(OC)c(OC)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])O.[Na+],,val
US05451566,FC(F)(F)c1ccc(-n2ccc3c(Cl)nccc32)c(Cl)c1.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1ccc2c(ccn2-c2ccc(C(F)(F)F)cc2Cl)c1Cl,,ClC(Cl)Cl,ClCCl,,,val
US20080306115A1,Cc1c(C(=O)N[C@H]2CCCC[C@H]2NC(=O)OC(C)(C)C)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(OS(=O)(=O)CCC(F)(F)F)cc1>>Cc1c(C(=O)N[C@H]2CCCC[C@H]2N)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(OS(=O)(=O)CCC(F)(F)F)cc1,,CO,,O=S(Cl)Cl,,val
US06350749B1,Cc1cc2c([nH]1)CC(c1ccccc1)CC2=O.Cl.N=C(N)NN>>Cc1cc2c([nH]1)CC(c1ccccc1)CC2=NNC(=N)N.Cl,,CCO,,Cl,O,val
US20150112077A1,CCNC1(Cl)C=CN(c2cccnc2)N1.O=C(O)CCSCCC(F)(F)F>>CCN(C(=O)CCSCCC(F)(F)F)c1cn(-c2cccnc2)nc1Cl,,CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US20100305122A1,NS(=O)(=O)c1ccc(F)c([N+](=O)[O-])c1.OCC1CCCC2(C1)OCCO2>>NS(=O)(=O)c1ccc(OCC2CCCC(=O)C2)c([N+](=O)[O-])c1,,C1CCOC1,,O,[H-].[Na+],val
US20150266834A1,COc1nc(Cl)nc(Cl)n1.Cc1cc(B(O)O)ccc1Cl>>COc1nc(Cl)nc(-c2ccc(Cl)c(C)c2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],val
US20120021907A1,CC1(C)OC(C)(C)C(=Cc2cc(Br)ccc2OC(F)(F)F)C1=O.OO>>CC1(C)OC(C)(C)C2(OC2c2cc(Br)ccc2OC(F)(F)F)C1=O,,CO,,[Li+].[OH-],,val
US20090012097A1,CI.COC(=O)C(C)(C)Oc1ccc2c(c1)CCN(C(=O)Nc1nc(-c3ccc(C(F)(F)F)cc3)cs1)C2>>COC(=O)C(C)(C)Oc1ccc2c(c1)CCN(C(=O)N(C)c1nc(-c3ccc(C(F)(F)F)cc3)cs1)C2,,CC#N,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050261291A1,CC(C)C=O.COc1cc(C2CC(C)(C)CC(C)(C)C2)c(N2CCNCC2)cc1OC>>COc1cc(C2CC(C)(C)CC(C)(C)C2)c(N2CCN(CC(C)C)CC2)cc1OC,,C1CCOC1,CCOC(C)=O,CC(=O)O,O=C([O-])O.[Na+],val
US20090005344A1,OB(O)CCCCCBr.c1ccc2[nH]c(-c3cscn3)nc2c1>>OB(O)CCCCCn1c(-c2cscn2)nc2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20090069282A1,C#Cc1cnc(NC(=O)CN2CCCC2)c(C)c1.Clc1ccc(-c2ccc(I)nc2)cc1>>Cc1cc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)cnc1NC(=O)CN1CCCC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,C1CCNCC1,,val
US05599930,COC(=O)c1cc2ccc(OCCOCCOCCO)cc2[nH]1>>O=C(O)c1cc2ccc(OCCOCCOCCO)cc2[nH]1,,C1COCCO1,O,Cl,[K+].[OH-],val
US20120101127A1,CC1(C)CC(c2ccccc2N)Nc2ccc(Cl)cc21.O=S(=O)(Cl)c1cccnc1>>CC1(C)CC(c2ccccc2NS(=O)(=O)c2cccnc2)Nc2ccc(Cl)cc21,,ClCCl,,c1ccncc1,,val
US04199568,CC(C)(C)OC(=O)NCC(=O)O.CSCCCNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)OC(C)(C)C>>CSCCCNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)OC(C)(C)C,,ClCCl,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20070244131A1,CC(C(=O)O)c1cccc(Br)c1.CCCCOB(OCCCC)OCCCC>>CC(C(=O)O)c1cccc(B(O)O)c1,,CCOCC,,[Li]C(C)(C)C,,val
US06326386B1,Cc1cc(OCCNc2ccncc2)cc(C(=O)N(CCC#N)C(C)C)c1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F>>Cc1cc(OCCNc2ccncc2)cc(C(=O)N(CCC(N)=O)C(C)C)c1.O=C(O)C(F)(F)F,,ClCCl,O=C(O)C(F)(F)F,,,val
US20090069340A1,Cn1c(CBr)c(Cl)c(=O)n1C1CCCCC1.N#CC1CCN(c2ccccc2)CC1>>Cn1c(CN2CCC(C#N)(c3ccccc3)CC2)c(Cl)c(=O)n1C1CCCCC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120028974A1,CCOC(=O)C1(c2nc3c(Br)ccc(OC)n3n2)CC1>>COc1ccc(Br)c2nc(C3(C(=O)O)CC3)nn12,,C1COCCO1,O,[Li+].[OH-],,val
US06593355B2,Cc1nc(-c2ccc(NCc3nc4cc([C@@](C)(N)C(=O)N5CCCC5)ccc4n3C)cc2)no1.N#CCBr>>Cc1nc(-c2ccc(NCc3nc4cc([C@@](C)(NCC#N)C(=O)N5CCCC5)ccc4n3C)cc2)no1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110034464A1,N#Cc1ccccc1S(=O)(=O)N1CCCC1>>NCc1ccccc1S(=O)(=O)N1CCCC1,[Ni],CO,,,,val
US20090181989A1,CCN(CC)CCO.COc1ccc(Cn2cnc3c(-c4cc(O)c(Cl)cc4Cl)nc(Cl)nc32)cc1>>CCN(CC)CCOc1cc(-c2nc(Cl)nc3c2ncn3Cc2ccc(OC)cc2)c(Cl)cc1Cl,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06927214B1,CC(C)c1nc2cc(Cl)c(Cl)cc2nc1Cl.CSc1nnc(S)s1>>CSc1nnc(Sc2nc3cc(Cl)c(Cl)cc3nc2C(C)C)s1,,CN(C)C=O,,[F-].[K+],,val
US05504095,Nc1cc(F)ccc1CS(=O)(=O)[O-]>>O=S1(=O)Cc2ccc(F)cc2N1,,O=P(Cl)(Cl)Cl,,,,val
US20070208005A1,CC(C)(C)OC(=O)N1CCc2ccc(COS(C)(=O)=O)cc2CC1.COC(=O)c1c[nH]c(=O)cn1>>COC(=O)c1cnc(OCc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)CC3)cn1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20100076014A1,COC(O[Si](C)(C)C)=C(C)C.OC(Cc1ccccc1)c1ccc2c(cnn2-c2ccc(F)cc2)c1>>COC(=O)C(C)(C)C(Cc1ccccc1)c1ccc2c(cnn2-c2ccc(F)cc2)c1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20060111347A1,CC1(C)O[C@H](CS(=O)(=O)c2ccc3ccccc3c2)[C@H](C(=O)O)O1.N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21>>CC1(C)O[C@H](CS(=O)(=O)c2ccc3ccccc3c2)[C@H](C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)O1,,CCOC(C)=O,CN(C)C=O,On1nnc2ccccc21,,val
US04526978,CN=[N+]=[N-].Cc1ccc(S(=O)(=O)C#N)cc1>>Cc1ccc(S(=O)(=O)c2nnnn2C)cc1,,c1ccccc1,,,,val
US20020032330A1,COC(=O)C(Cl)Cc1ccc2c(CCc3nc(-c4ccccc4)oc3C)noc2c1.Sc1ccccc1>>COC(=O)C(Cc1ccc2c(CCc3nc(-c4ccccc4)oc3C)noc2c1)Sc1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US20080182838A1,CC(C)(C)OC(=O)Cn1nnc(-c2cnc(N3CCC(Oc4cc(F)ccc4Br)CC3)cn2)n1>>O=C(O)Cn1nnc(-c2cnc(N3CCC(Oc4cc(F)ccc4Br)CC3)cn2)n1,,O,O=C(O)C(F)(F)F,,,val
US20040014746A1,CC(=O)OC(C)=O.CC1SC(c2ccc(N3CC(CN)OC3=O)cc2F)=NNC1=O>>CC(=O)NC[C@H]1CN(c2ccc(C3=NNC(=O)[C@H](C)S3)c(F)c2)C(=O)O1,,c1ccncc1,,O=C(O)C(F)(F)F,,val
US20090163469A1,CN(C)C[C@@]12CCCN1[C@@H](C(Cl)(Cl)Cl)OC2=O.N>>CN(C)C[C@@]1(C(N)=O)CCCN1,,CO,,,,val
US20050176724A1,COC(=O)c1cccc(C=C2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1>>Cc1ccc2c(OCCN3CCC(=Cc4cccc(C(=O)O)c4)CC3)cccc2n1,,CO,,[Na+].[OH-],,val
US03966713,CC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](F)C[C@]12C>>C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](F)C[C@]2(C)[C@@H](O)CC[C@@H]12,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US05455273,CN.CNCC(C(=O)OC(C)(C)C)c1ccc(C2CCC(=O)CC2)cc1>>CNCC(C(=O)OC(C)(C)C)c1ccc([C@@H]2CC[C@@H](NC)CC2)cc1,,CCOC(C)=O,CO,,,val
US20090018054A1,COc1ccc(C(C)(C)C)cc1B(O)O.C[C@H]1C[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1cc2c(cc1I)CCC2>>COc1ccc(C(C)(C)C)cc1-c1cc2c(cc1CN1C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]1C)CCC2,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20150299190A1,Clc1nccc2sccc12.O=[N+]([O-])c1ccc(Cl)c(B(O)O)c1>>O=[N+]([O-])c1ccc(Cl)c(-c2nccc3sccc23)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,[Li+].[OH-],,val
US20050227953A1,CC(=O)Cl.CNC1CCC2(C)C(=CCC3C2CCC24CN(C)C(C)C2CCC34)C1>>CC(=O)N(C)C1CCC2(C)C(=CCC3C2CCC24CN(C)C(C)C2CCC34)C1,,ClCCl,,CCN(CC)CC,,val
US20030212071A1,CCCS(=O)(=O)NCC(Nc1ccc(C#N)cc1)c1cc(OC)c(OCc2ccccc2)cc1[N+](=O)[O-]>>CCCS(=O)(=O)NCC(Nc1ccc(C#N)cc1)c1cc(OC)c(OCc2ccccc2)cc1N,[Pt],CCO,,,,val
US20080004285A1,NC(=O)c1nc(-c2ccc(F)cc2)ccc1N.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Oc1nc(O)c2nc(-c3ccc(F)cc3)ccc2n1,,C1COCCO1,,,,val
US20100137278A1,OC1(c2nccnc2F)CCOCC1.Oc1ccc(Nc2nc3ccccc3s2)cc1>>OC1(c2nccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CCOCC1,,CS(C)=O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090093444A1,CSc1ccc(-c2c([C@@H]3CCC(F)(F)C[C@H]3COCc3ccccc3)nn(CC(F)(F)F)c2O)cc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CSc1ccc(-c2c([C@@H]3CCC(F)(F)C[C@H]3COCc3ccccc3)nn(CC(F)(F)F)c2OS(=O)(=O)C(F)(F)F)cc1,,ClCCl,,c1ccncc1,,val
US20090181942A1,CCOC(=O)C[C@H]1O[C@H](c2ccc(C)cc2OC)c2cc(Cl)ccc2-n2c1nnc2C(F)(F)F>>COc1cc(C)ccc1[C@H]1O[C@H](CC(=O)O)c2nnc(C(F)(F)F)n2-c2ccc(Cl)cc21,,C1COCCO1,,Cl,O,val
US20080161302A1,CNCc1ccccc1.O=C(Cl)c1cccc([N+](=O)[O-])c1>>CN(Cc1ccccc1)C(=O)c1cccc([N+](=O)[O-])c1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US06156702,CC(C)(C)OC(=O)c1ccc(Cl)c(C(O)c2ccccn2)c1Cl>>O=C(O)c1ccc(Cl)c(C(O)c2ccccn2)c1Cl,,Cc1ccccc1,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US03992535,COC(=O)C1=C(O)c2ccc3ccccc3c2S(=O)(=O)N1C.Nc1nc2c(s1)CCCC2>>CN1C(C(=O)Nc2nc3c(s2)CCCC3)=C(O)c2ccc3ccccc3c2S1(=O)=O,,ClCCCl,,,,val
US20120129840A1,CCCC(C(=O)OC)c1c(C)nc(Cl)nc1-c1ccc(C)cc1.Cc1ccc(B(O)O)cc1>>CCCC(C(=O)OC)c1c(C)nc(-c2ccc(C)cc2)nc1-c1ccc(C)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,CCN(C(C)C)C(C)C,,val
US05883294,COc1cc(C)c(Cc2ccc(OC)c(C(C)C)c2)c(C)c1>>Cc1cc(O)cc(C)c1Cc1ccc(O)c(C(C)C)c1,,ClCCl,,BrB(Br)Br,,val
US20120172351A1,COC(=O)C[C@@H]1COc2cc(NCc3cccc(-n4c(C)nc5ccccc54)c3C)ccc21>>Cc1c(CNc2ccc3c(c2)OC[C@H]3CC(=O)O)cccc1-n1c(C)nc2ccccc21,,C1CCOC1,CO,[Na+].[OH-],,val
US20150057271A1,COc1cc(C#N)ccc1N1CCOc2cc(S(=O)(=O)Cl)c(F)cc21.COc1ccc(CNc2nccs2)cc1>>COc1cc(C#N)ccc1N1CCOc2cc(S(=O)(=O)Nc3nccs3)c(F)cc21,,C1CCOC1,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20070135490A1,O=C(OO)c1cccc(Cl)c1.O=S(c1cccc(COCCO)c1)C1CCCC1>>O=S(=O)(c1cccc(COCCO)c1)C1CCCC1,,ClCCl,,,,val
US20090005557A1,O=C1CCC(=O)N1Br.c1c[se]c(-c2cc[se]c2-c2cc[se]c2-c2cc[se]c2-c2cc[se]c2-c2cc[se]c2-c2cc[se]c2-c2ccc[se]2)c1>>BrC1(c2[se]ccc2-c2[se]ccc2-c2ccc[se]2)CC=C[Se]1,,ClC(Cl)Cl,,,,val
US05081131,CC(CCN)c1ccccn1.CSC1=Nc2c(C)ccc3cccc1c23.I>>Cc1ccc2cccc3c2c1N=C3NCCCCc1cccnc1.I,,CCO,,,,val
US05426105,CCCCc1ncc2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2CC(=O)OC(C)(C)C>>CCCCc1ncc2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2CC(=O)O,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20110065691A1,COc1ccc(N2CCNC(Cc3ccccc3)C2)cc1OC1CCC1.Clc1ncccn1>>COc1ccc(N2CCN(c3ncccn3)[C@@H](Cc3ccccc3)C2)cc1OC1CCC1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20070218483A1,Cc1ccc(C(=O)c2ccc([N+](=O)[O-])c(F)c2)cc1.O=C1CCC(=O)N1Br>>O=C(c1ccc(CBr)cc1)c1ccc([N+](=O)[O-])c(F)c1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20050171131A1,CCc1nc(N)nc(N)c1-c1ccc(N)c(C)c1.CS(=O)(=O)c1ccc(C=O)cc1>>CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(C)c1,,CO,,[BH3-]C#N.[Na+],,val
US20090004185A1,C=C[Sn](CCCC)(CCCC)CCCC.CN(C)c1nc(NCc2ccc(NC(=O)C3CCN(Cc4ccccc4)CC3)cc2)c2ccc(I)cc2n1>>C=Cc1ccc2c(NCc3ccc(NC(=O)C4CCN(Cc5ccccc5)CC4)cc3)nc(N(C)C)nc2c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O,,val
US20160229816A1,CC(OC(=O)OCCOC1CCCCO1)n1nc(C#N)c(-c2cccc(OCc3cc(C(F)(F)F)ccc3C(F)(F)F)c2)n1>>CC(OC(=O)OCCO)n1nc(C#N)c(-c2cccc(OCc3cc(C(F)(F)F)ccc3C(F)(F)F)c2)n1,,C1CCOC1,CCOC(C)=O,Cl,,val
US06770785B1,CC(C)(C)c1cc(CBr)cc(C(C)(C)C)c1O.CN(C)c1ccc(N)cc1>>CN(C)c1ccc(NCc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1,,C1CCOC1,,,,val
US20160207930A1,Cc1cccc([C@H]2[C@@H]3CCC(=O)N3CCN2C(=O)OC(C)(C)C)c1C>>Cc1cccc([C@@H]2NCCN3C(=O)CC[C@@H]23)c1C,,CO,,Cl,[Na+].[OH-],val
US20060074102A1,N=C(NO)c1cc2c(Oc3ccc(I)cc3)cncc2s1.S=C(n1ccnc1)n1ccnc1>>O=c1nc(-c2cc3c(Oc4ccc(I)cc4)cncc3s2)[nH]s1,,CO,ClC(Cl)Cl,C1CCOC1,,val
US20120004203A1,CC1=C(C#N)[C@@H](c2ccc(C#N)cc2)n2nc(N)nc2N1c1cccc(C(F)(F)F)c1.CCOC(=O)Cl>>CCOC(=O)Nc1nc2n(n1)[C@H](c1ccc(C#N)cc1)C(C#N)=C(C)N2c1cccc(C(F)(F)F)c1,,c1ccncc1,,C1CCOC1,,val
US20150353533A1,CCOC(=O)C(N)=NNC(=O)Cc1cccc(F)c1>>CCOC(=O)c1nnc(Cc2cccc(F)c2)[nH]1,,CO,,,,val
US20130336920A1,COC(=O)c1ccnc(-c2cc(N3CCCCC3)ccc2[N+](=O)[O-])c1>>O=C(O)c1ccnc(-c2cc(N3CCCCC3)ccc2[N+](=O)[O-])c1,,C1CCOC1,O,[Li+].[OH-],,val
US20120058989A1,CC(C)(C)OC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]1C(O)C#C[Si](C)(C)C.S=C(Cl)Oc1ccccc1>>CC(C)(C)OC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]1C(C#C[Si](C)(C)C)OC(=S)Oc1ccccc1,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US05086180,COC(=O)c1sc(OCc2ccc3ccccc3n2)cc1S(=O)(=O)NC(F)(F)F>>O=C(O)c1sc(OCc2ccc3ccccc3n2)cc1S(=O)(=O)NC(F)(F)F,,CO,,[Na+].[OH-],,val
US20090131413A1,CC(C)(C)OC(=O)NC1CCNCC1.CN(C)C(=O)Cl>>CN(C)C(=O)N1CCC(NC(=O)OC(C)(C)C)CC1,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20050014753A1,NCCO.O=C(O)c1ccc(-c2ncnc(Nc3ccc(OC(F)(F)F)cc3)n2)cc1>>O=C(NCCO)c1ccc(-c2ncnc(Nc3ccc(OC(F)(F)F)cc3)n2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090169483A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1cc(C2OCCO2)cc(OCCOCCOCCOCCN)c1OC>>COc1cc(C2OCCO2)cc(OCCOCCOCCOCCNC(=O)OC(C)(C)C)c1OC,,ClCCl,,CCN(CC)CC,,val
US20140038964A1,CC(C)c1ccccc1Br.N#C[Cu]>>CC(C)c1ccccc1C#N,,CN(C)C=O,,,,val
US20160264518A1,CO.COCCn1c(Nc2ccccc2/C=C/C(=O)OC)nc2ccccc21.NO>>COCCn1c(CNc2ccccc2/C=C/C(=O)NO)nc2ccccc21,,CO,,C1CCOC1,[Na+].[OH-],val
US06028096,CC(=O)c1c(C#N)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N>>CC(=O)c1cn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)nc1C#N,,C1CCOC1,,CC(C)(C)ON=O,,val
US20160083403A1,CNN.COc1cccc(C(=O)NN(C(=O)c2ccc(C=O)c(B3OC(C)(C)C(C)(C)O3)c2)C(C)(C)C)c1C>>COc1cccc(C(=O)NN(C(=O)c2ccc3c(c2)B(O)N(C)N=C3)C(C)(C)C)c1C,,CCO,,,,val
US20160024104A1,COc1cc2sc(N)nc2cc1C.[Br-]>>COc1cc2sc(Br)nc2cc1C,,CC#N,,CC(C)(C)ON=O,,val
US20060111402A1,FC(F)(F)Cc1cc2cc(Cl)c(Cl)cc2[nH]1.FC(F)(F)Cc1nc2c(Cl)cccc2n1Cl.N#Cc1ccc(CBr)cc1>>N#Cc1ccc(Cn2c(CC(F)(F)F)nc3cc(Cl)c(Cl)cc32)cc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20040077622A1,OCc1cc2n(n1)CSCC2>>O=Cc1cc2n(n1)CSCC2,O=[Mn]=O,ClC(Cl)Cl,,,,val
US20080300242A1,COC(=O)c1cccc(-c2nc3ccccn3c2-c2ccnc(Nc3ccc(N4CCOCC4)cc3OC)n2)c1.Nc1c(F)cccc1F>>COc1cc(N2CCOCC2)ccc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US04421749,CC(C)C[Al](CC(C)C)CC(C)C.Oc1ccccc1>>CC(C)C[Al](CC(C)C)Oc1ccccc1,,Cc1ccccc1,,,,val
US20070073064A1,CC(C)(C)OC(=O)NCC(=O)N[C@@H]1CCNC1.Cc1ccc2c(CN(C)C)c[nH]c2c1.Cl>>Cc1ccc2c(CN3CC[C@@H](NC(=O)CNC(=O)OC(C)(C)C)C3)c[nH]c2c1.Cl,,CC(C)O,,,,val
US05541229,CCCCc1nc2ccc(OC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCCc1nc2ccc(OC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120329780A1,COc1ccc(Cn2cc3nc(C4CCN(C)CC4)nc(Cl)c3n2)cc1.Nc1ccc2c(c1)NCCO2>>CN1CCC(c2nc(Nc3ccc4c(c3)NCCO4)c3[nH]ncc3n2)CC1,C1COCCO1,CO,,Cl,,val
US05260331,CCCCNC(=O)c1ccc(Cl)cc1>>CCCCc1cc(Cl)ccc1CN,,C1CCOC1,,Cl,O,val
US05538852,COC(CCCBr)(OC)OC.Cc1cc(Cl)ccc1Cl>>COC(=O)CCCCc1cc(Cl)ccc1Cl,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US05097023,CC(=O)OC1O[C@H](COCc2ccccc2)[C@H](OC(C)=O)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1.Cl>>CC(=O)O[C@H]1[C@@H](COCc2ccccc2)O[C@H](Cl)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1,,CCOCC,,,,val
US20100160308A1,NC(=O)c1sc(-n2cnc3ccc(OCCCCl)cc32)nc1-c1cccc(Cl)c1.OCCNCCO>>NC(=O)c1sc(-n2cnc3ccc(OCCCN(CCO)CCO)cc32)nc1-c1cccc(Cl)c1,,CN(C)C=O,,[I-].[K+],,val
US20070208054A1,CN.O=C(O)CCc1ccc(Br)cc1>>CNC(=O)CCc1ccc(Br)cc1,,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US06759428B2,O=C1CC(OC(=O)OCc2ccccc2)C(=O)N1.OCCNCCO>>O=C(OCc1ccccc1)N(CCO)CCO,,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US05262502,C=CCCCCBr.O=Cc1ccc(O)cc1>>CCCCC=COc1ccc(C=O)cc1,,CO,,C[O-].[Na+],,val
US20100216836A1,NC(=O)C1CCCN(CC2COc3ccccc3O2)C1>>NCC1CCCN(CC2COc3ccccc3O2)C1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US04214094,CCOC(=O)C(C)Br.Oc1ccc(CNc2ccc(Cl)cc2)cc1>>CCOC(=O)C(C)Oc1ccc(CNc2ccc(Cl)cc2)cc1,,CCO,,[Na],,val
US03941782,C1CSCCN1.COC(=O)CCCI>>COC(=O)CCCN1CCSCC1,,c1ccccc1,,CCN(CC)CC,,val
US20080108648A1,CO.O=C(Cl)c1ccc2nc(-c3ccccc3)oc(=O)c2c1.c1ccn2cncc2c1>>COC(=O)c1cc(C(=O)c2ncc3ccccn23)ccc1NC(=O)c1ccccc1,CN(C)c1ccncc1,CC#N,CN(C)C=O,CCN(CC)CC,,val
US05852016,C=CCC(c1c(Cl)c(Cl)cc2nc(OC)c(OC)nc12)S(C)(=O)=O>>C=CCC(c1c(Cl)c(Cl)cc2[nH]c(=O)c(=O)[nH]c12)S(C)(=O)=O,,C1COCCO1,,Cl,,val
US20130102776A1,CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2O/C(=C\c2c[nH]c4cc([N+](=O)[O-])ccc24)C3=O)CC1.Cl.ClCCl>>Cl.Cl.O=C1/C(=C/c2c[nH]c3cc([N+](=O)[O-])ccc23)Oc2c1ccc(O)c2CN1CCNCC1,,C1COCCO1,ClCCl,,,val
US05283361,Fc1ccc(Sc2ccccc2C=CCBr)cc1.NOC1CCCCO1>>Fc1ccc(Sc2ccccc2C=CCNOC2CCCCO2)cc1,,CN(C)C=O,,O,,val
US20080214807A1,CC(C)(C)OC(=O)N1CCC2(CC1)CC(C(=O)N1CCN(c3ncccc3C(F)(F)F)CC1)=NO2.Cl>>Cl.O=C(C1=NOC2(CCNCC2)C1)N1CCN(c2ncccc2C(F)(F)F)CC1,,CO,,CC(C)O,,val
US20070244131A1,COc1ccc(B(O)O)cn1.COc1ccc(CCNc2cc(Cl)nc(OC)n2)cc1>>COc1ccc(CCNc2cc(-c3ccc(OC)nc3)nc(OC)n2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090030031A1,Nc1nc2cc(Br)ccc2c2c1nc(CO)n2CC1CCOCC1.O=C(c1cccc(B(O)O)c1)N1CCCC1>>Nc1nc2cc(-c3cccc(C(=O)N4CCCC4)c3)ccc2c2c1nc(CO)n2CC1CCOCC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,O,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20130196974A1,CSc1ccc([N+](=O)[O-])cc1>>CSc1ccc(N)cc1,[Ni],CO,,[H][H],,val
US20100099665A1,CC(C)(CO)CBr.O=c1[nH]ccc2cc(Br)ccc12>>CC(C)(CO)Cn1ccc2cc(Br)ccc2c1=O,,CN1CCCC1=O,O,[I-].[Na+],O=C([O-])[O-].[Cs+].[Cs+],val
US20050245572A1,COC=COC(c1cc(I)c(OC)c2ccccc12)C1(c2ccc(F)cc2)CCN(C)CC1.N#C[Cu]>>COC=COC(c1cc(C#N)c(OC)c2ccccc12)C1(c2ccc(F)cc2)CCN(C)CC1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20080090905A1,CS(=O)(=O)Oc1ccc(OCCc2ccc(CC(SCCc3ccc(O)cc3)C(=O)O)cc2)cc1.C[C@@H](N)c1cccc2ccccc12>>CS(=O)(=O)Oc1ccc(OCCc2ccc(CC(SCCc3ccc(O)cc3)C(=O)O)cc2)cc1.C[C@@H](N)c1cccc2ccccc12,,CCO,,,,val
US04876366,CC(C(=O)O)c1ccc(O[Si](C)(C)C(C)(C)C)cc1.CI>>CC(C)(C(=O)O)c1ccc(O[Si](C)(C)C(C)(C)C)cc1,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US20060074075A1,NO.O=C1CCCc2ccc([N+](=O)[O-])cc21>>O=[N+]([O-])c1ccc2c(c1)C(=NO)CCC2,,c1ccncc1,,,,val
US04847367,CC(=O)OC(C)=O.CCCCCCCCCCCCc1ccc(N)cc1>>CCCCCCCCCCCCc1ccc(NC(C)=O)cc1,,Cc1ccccc1,,,,val
US20100056511A1,O=[N+]([O-])c1ccnc(Cl)c1.OCCOCc1ccccc1>>Clc1cc(OCCOCc2ccccc2)ccn1,,C1CCOC1,,[H-].[Na+],,val
US20110077252A1,Nc1ccc(-c2nc(O)cc(C(F)(F)F)n2)nc1.O=C(Cl)CCl>>O=C(CCl)Nc1ccc(-c2nc(O)cc(C(F)(F)F)n2)nc1,,C1CCOC1,,CCN(CC)CC,,val
US20090170828A1,COC(=O)c1ccc(N2CC(OCc3ccccc3C(F)(F)F)C2)nn1.NN>>NNC(=O)c1ccc(N2CC(OCc3ccccc3C(F)(F)F)C2)nn1,,CCO,,,,val
US20090054435A1,COc1ccc(C(=O)c2ccc(O)cc2)c(OC(C)(C)C(=O)OC(C)(C)C)c1.ClCc1cc(-c2ccccc2)on1>>COc1ccc(C(=O)c2ccc(OCc3cc(-c4ccccc4)on3)cc2)c(OC(C)(C)C(=O)O)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04226773,CC(=O)N1CCN=C1Nc1cc(C)nn1-c1cccc2ccccc12>>Cc1cc(NC2=NCCN2)n(-c2cccc3ccccc23)n1,,CO,,Cl,,val
US20050020654A1,CCCc1nc2c(C)cc(C(=O)OC)cc2[nH]1.CNc1ccccc1N>>CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2[nH]1,,O,,N,,val
US20140275084A1,CNCc1ccccc1.COC(=O)c1ccnc(-c2cn(CCOS(C)(=O)=O)cn2)c1>>COC(=O)c1ccnc(-c2cn(CCN(C)Cc3ccccc3)cn2)c1,,Cc1ccccc1,,,,val
US03948973,COc1ccc(C2(C)CC2(Cl)Cl)cc1>>CC1(c2ccc(O)cc2)CC1(Cl)Cl,,ClCCl,,BrB(Br)Br,,val
US06274619B1,CCOC(=O)C1CCc2cc(C(=N)N)sc2C1.Cl>>Cl.N=C(N)c1cc2c(s1)CC(C(=O)O)CC2,,Cl,,,,val
US20100048940A1,CCCCCCCCCC=O.OCCOCCOCCOCCO>>CCCCCCCCCC=O.OCCOCCOCCOCCO,[Pd],,,,,val
US20110237584A1,C[Si](C)(C)C(F)(F)F.O=Cc1cccc(Cl)c1>>OC(c1cccc(Cl)c1)C(F)(F)F,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080287409A1,CCOC(=O)C(Cl)C(=O)C(F)F.COc1ccc(C(N)=S)cc1>>CCOC(=O)c1sc(-c2ccc(OC)cc2)nc1C(F)F,,CCO,,,,val
US05189179,Nc1ccc(C(F)(F)F)cc1.O=C(Cl)CCCCCBr>>O=C(CCCCCBr)Nc1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20100120669A1,Nc1nnc(Cc2ccccc2Br)s1.OB(O)c1ccccc1Cl>>Nc1nnc(Cc2ccccc2-c2ccccc2Cl)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US05972951,CN.Cc1cc(C=O)ccc1Br>>Cc1cc(C=CN)ccc1Br,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20060131541A1,CCCC1CCC(C2CCC(c3ccc(O)c(CCC(=O)OCC)c3)CC2)CC1>>CCCC1CCC(C2CCC(c3ccc4c(c3)CCC(=O)O4)CC2)CC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070259924A1,O=C(NCc1cn(-c2ccc(-n3ccccc3=O)cc2F)cn1)c1ccc(Cl)s1.O=C1CNCCN1>>O=C1CN(c2cc(-n3ccccc3=O)ccc2-n2cnc(CNC(=O)c3ccc(Cl)s3)c2)CCN1,,CS(C)=O,,,,val
US20040209905A1,COc1cc2ncnc(Oc3ccc(N)cc3C)c2cc1OC.COc1ccccc1N=C=O>>COc1ccccc1NC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)c(C)c1,,ClC(Cl)Cl,,CO,,val
US20130096113A1,CS(=O)(=O)Cl.O[C@H]1CCCC[C@H]1Nc1nc2ccc(Cn3cnc4cc(F)cnc43)cc2s1>>CS(=O)(=O)O[C@H]1CCCC[C@H]1Nc1nc2ccc(Cn3cnc4cc(F)cnc43)cc2s1,,ClCCl,,O=C([O-])O.[Na+],,val
US20090181928A1,O=[N+]([O-])c1cc(F)c(F)cc1OCc1ccccc1>>Nc1cc(F)c(F)cc1OCc1ccccc1,[Pt],CCOC(C)=O,,,,val
US20080009530A1,CCOC(=O)CCc1cc(OCC2CC2)nn1Cc1ccc(C(F)(F)F)cc1Cl>>O=C(O)CCc1cc(OCC2CC2)nn1Cc1ccc(C(F)(F)F)cc1Cl,,CCO,,C1CCOC1,[Na+].[OH-],val
US20120028953A1,Ic1ccc(OC2CNC2)nc1.O=C=Nc1cccnc1>>O=C(Nc1cccnc1)N1CC(Oc2ccc(I)cn2)C1,,ClCCl,,CCN(CC)CC,Cl,val
US20140288123A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(C)c(CN)c(O)n1>>Cc1cc(C)c(CNC(=O)OC(C)(C)C)c(O)n1,,ClCCl,,CCN(CC)CC,O,val
US20140163035A1,OCCC(O)c1cccnc1Br>>OC1CCOc2ncccc21,,CC(C)(C)O,,CC(C)(C)O[K],,val
US20070185103A1,COC(=O)c1c[nH]c(=O)c(-c2ccccn2)c1.IC1CCCC1>>COC(=O)c1cc(-c2ccccn2)c(=O)n(C2CCCC2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04632925,COc1cccc(C(O)(CC2CCNCC2)c2cccc(OC)c2)c1>>COc1cccc(C(=CC2CCNCC2)c2cccc(OC)c2)c1,,O=C(O)C(F)(F)F,,,,val
US20120238574A1,CC(C)(C)OC(=O)N1CCC(n2ccc3cc([N+](=O)[O-])ccc32)CC1>>CC(C)(C)OC(=O)N1CCC(n2ccc3cc(N)ccc32)CC1,[Pd],CCO,,,,val
US20110136801A1,COC(=O)c1ccc(F)c(O)c1>>OCc1ccc(F)c(O)c1,,C1CCOC1,,[BH4-].[Li+],,val
US05602149,CCC(=O)N(C(=O)CC)c1c(I)cc(Br)cc1S(=O)(=O)O.ClP(Cl)(Cl)(Cl)Cl>>CCC(=O)N(C(=O)CC)c1c(I)cc(Br)cc1S(=O)(=O)Cl,,ClCCl,,CCN(CC)CC,CCOCC,val
US20100210636A1,O=C1Nc2ccc(Cl)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1>>O=C1Nc2ccc(Cl)cc2[C@](CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1,,CC(C)O,,CCCCCC,,val
US20100004466A1,COC(=O)CS.O=Cc1c(Br)cccc1Br>>COC(=O)c1cc2c(Br)cccc2s1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070043036A1,CCN=C=O.Cc1c(C(=O)NN)cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)n1-c1cccc(C(F)(F)F)c1>>CCNC(=O)NNC(=O)c1cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)n(-c2cccc(C(F)(F)F)c2)c1C,,C1COCCO1,,,,val
US05739135,CC(C)(C)OC(=O)NC1CCNCC1.ClC/C=C\CC(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)NC1CCN(C/C=C\CC(c2ccccc2)c2ccccc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130131018A1,CCOC(CN)OCC.CCOc1cccc(C=O)c1O>>CCOc1cccc(/C=N/CC(OCC)OCC)c1O,,Cc1ccccc1,,O,,val
US20050143452A1,[N-]=[N+]=NCC1Cc2cccc(-c3ccc(C(F)(F)F)cc3)c2O1>>NCC1Cc2cccc(-c3ccc(C(F)(F)F)cc3)c2O1,[Pd],,,,,val
US20060040917A1,COc1cccc(-c2coc3cc(OC)ccc3c2=O)c1>>COc1cccc(C2COc3cc(OC)ccc3C2=O)c1,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20140171403A1,NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)C1.O=C(O)CCCc1c[nH]nn1>>O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)C1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080194618A1,BrCCCOCc1ccccc1.OC(c1ccccc1)(c1ccccc1)C12CCN(CC1)C2>>OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOCc3ccccc3)(CC1)C2.[Br-],,CC#N,,,,val
US20160168126A1,CC(=O)OC1C(Cl)=C(C)C(=O)N1c1cc(C(C)(C)C)n(C)n1>>CC1=C(Cl)C(O)N(c2cc(C(C)(C)C)n(C)n2)C1=O,,C1CCCCC1,,CC(=O)O,O,val
US20120244294A1,O=C(O)c1cc(F)c(F)c(F)c1F.O=C=O>>Cc1c(F)c(F)c(F)c(F)c1C(=O)O,,C1CCOC1,,[Li]CCCC,,val
US20090221645A1,O=C(c1cccc2ccccc12)C(Br)COCc1ccccc1.S=C1NCCN1>>COCC1=C(c2cccc3ccccc23)N2CCN=C2S1,,CC(=O)O,,CO,,val
US20040058939A1,O=C1NCC(OC2CCCCO2)c2cc3cccnc3n21>>O=C1NCC(O)c2cc3cccnc3n21,,ClCCl,,,,val
US04988723,CC(=O)OC(C)=O.CCC1(CC)Oc2ccc(C#N)cc2[C@@H](N2CCSC2=NC#N)[C@@H]1O>>CCC1(CC)Oc2ccc(C#N)cc2[C@@H](N2CCSC2=NC#N)[C@@H]1OC(C)=O,,CCOC(C)=O,c1ccncc1,,,val
US05236937,CCc1cc(N)c(I)c(CC)n1.O=[N+]([O-])c1ccc(-n2nnnc2-c2ccccc2-c2ccc(CBr)cc2)cc1>>CCc1cc(NCc2ccc(-c3ccccc3-c3nnnn3-c3ccc([N+](=O)[O-])cc3)cc2)c(I)c(CC)n1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US04788195,CC(=O)c1cccc(Nc2nccc(-c3cccnc3)n2)c1>>CC(O)c1ccc(Nc2nccc(-c3cccnc3)n2)cc1,,CCO,,CC(=O)O,[BH4-].[Na+],val
US20090069297A1,COc1cnc2c(Oc3ccc(N)cc3)ccnc2c1.Cc1cc(-c2nnc(Cl)c3ccccc23)sc1C>>COc1cnc2c(Oc3ccc(Nc4nnc(-c5cc(C)c(C)s5)c5ccccc45)cc3)ccnc2c1,,CC(C)(C)O,,,,val
US20050090524A1,CC(C)(C)OC(=O)NC1CCNCC1.Cc1ccc2nc(Cl)ccc2c1NC(=O)CC12CC3CC(CC(C3)C1)C2>>Cc1ccc2nc(N3CCC(NC(=O)OC(C)(C)C)CC3)ccc2c1NC(=O)CC12CC3CC(CC(C3)C1)C2,,CN1CCCC1=O,,O,O=C([O-])[O-].[K+].[K+],val
US06111115,CCOC(=O)C(C)(C(=O)OCC)c1ccc([N+](=O)[O-])c(C(C(C)=O)C(=O)OC)c1>>CC(C(=O)O)c1ccc([N+](=O)[O-])c(CC(=O)O)c1,,CO,,Cl,[Na+].[OH-],val
US20020193367A1,CC(C)(C)OC(=O)Nc1cc(Cl)c(C(F)(F)F)cc1[N+](=O)[O-].CCCNC>>CCCN(C)c1cc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])cc1C(F)(F)F,,CS(C)=O,,CCN(CC)CC,,val
US03935223,CC=CC(=O)CC(=O)OCC.CCOC(=O)CC(=N)N>>CCOC(=O)C1=C(C)NC(N)=C(C(=O)OCC)C1C,,CCO,,CC(C)O,,val
US20020169192A1,CCCCCCCNCCc1cccc(OC(C)(CC)C(=O)OCc2ccccc2)c1.O=S(=O)(Cl)Cc1ccc(F)cc1>>CCCCCCCN(CCc1cccc(OC(C)(CC)C(=O)OCc2ccccc2)c1)S(=O)(=O)Cc1ccc(F)cc1,,CCOC(C)=O,,CCN(CC)CC,ClCCl,val
US20130102776A1,CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2O/C(=C\c2c[nH]c4ccc([N+](=O)[O-])cc24)C3=O)CC1.Cl.ClCCl>>Cl.Cl.O=C1/C(=C/c2c[nH]c3ccc([N+](=O)[O-])cc23)Oc2c1ccc(O)c2CN1CCNCC1,,C1COCCO1,ClCCl,,,val
US20090203657A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(C)c(-c3cccc(CN4C[C@@H]5C[C@H]4CN5)c3)c2)n1.Cl>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(C)c(-c3cccc(CN4C[C@@H]5C[C@H]4CN5)c3)c2)n1.Cl,,CCO,,,,val
US05457099,O=c1cc(CCBr)c2cc([N+](=O)[O-])ccc2[nH]1.c1ccc2c(C3CCNCC3)c[nH]c2c1>>O=c1cc(CCN2CCC(c3c[nH]c4ccccc34)CC2)c2cc([N+](=O)[O-])ccc2[nH]1,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20060235029A1,CCN(CC)CCCNc1nc(-c2cccc(C(=O)O)c2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1.Nc1nccs1>>CCN(CC)CCCNc1nc(-c2cccc(C(=O)Nc3nccs3)c2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060074075A1,CC(=O)Cl.c1ccc2c(c1)CCN2>>CC(=O)N1CCc2ccccc21,,ClCCl,,O=C([O-])O.[Na+],,val
US20090227584A1,CSCCO.Ic1cccc2nc(N[C@@H]3CCc4ccccc43)ccc12>>CSCCOc1cccc2nc(N[C@@H]3CCc4ccccc43)ccc12,I[Cu]I,Cc1ccccc1,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US20090203697A1,COC(=O)c1ccc(-n2cnc(C)n2)c(OC)c1>>COc1cc(C=O)ccc1-n1cnc(C)n1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04696930,Cc1cccc(C)c1NC(=O)CCCc1cccnc1>>Cc1cccc(C)c1NCCCCc1cccnc1,,C1CCOC1,,B,CO,val
US20150018546A1,C1COCCO1.CCN(CC)CC.CCOC(=O)c1c(O)c2c(Cl)ncnc2n(OCc2ccccc2)c1=O.NCc1ccccc1>>O=C(NCc1ccccc1)c1c(O)c2c(NCc3ccccc3)ncnc2n(OCc2ccccc2)c1=O,,C1COCCO1,,,,val
US20050182103A1,COC(=O)c1cc(-c2ccccc2)c(-c2ccc(Cl)cc2)nc1OC>>COc1nc(-c2ccc(Cl)cc2)c(-c2ccccc2)cc1C(=O)O,,CO,O,Cl,[Na+].[OH-],val
US20020099035A1,CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCN(C(=O)c3ccccc3)CC2)cc1>>CC#CCOc1ccc(S(=O)(=O)C2(C(=O)O)CCN(C(=O)c3ccccc3)CC2)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20100144706A1,CC(C)(C)OC(=O)N1CCN(C2CCN(c3ccc([N+](=O)[O-])cc3)CC2)CC1>>CC(C)(C)OC(=O)N1CCN(C2CCN(c3ccc(N)cc3)CC2)CC1,[Ni],CO,ClCCl,,,val
US20090105287A1,Cc1cc(Cl)nc(N)n1.ClI.N>>Cc1nc(N)nc(N)c1I,,CO,,[Na+].[OH-],,val
US20050137171A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOP(=O)(Oc1ccc2[nH]nc(I)c2c1)c1ccccc1>>CCOP(=O)(Oc1ccc2c(c1)c(I)nn2C(=O)OC(C)(C)C)c1ccccc1,,ClCCl,,CN(C)c1ccccn1,,val
US20140031336A1,CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C.CN(C)CCN>>CC(=O)N1c2ccc(-c3ccc(C(=O)NCCN(C)C)cc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06852721B2,CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2c1cncc(-c2ccsc2)c1>>c1cc(-c2cncc(N3C[C@@H]4C[C@H]3CN4)c2)cs1,,COc1ccccc1,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20140069301A1,CO[Si](C)(OC)OC.CO[Si](CC(C)C)(OC)OC.[K+].[OH-]>>CO[Si](C)(OC)OC.CO[Si](CC(C)C)(OC)OC.[K+].[OH-],,O,,,,val
US20100144787A1,CI.COC(=O)COc1ccc(Cl)c2[nH]c(=O)c(Cc3ccc(-n4cccn4)cc3)c(C)c12>>COC(=O)COc1ccc(Cl)c2nc(OC)c(Cc3ccc(-n4cccn4)cc3)c(C)c12,,CC(=O)O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20030018057A1,CC(=O)Cl.CCOC(=O)C(Cc1ccc(-c2cccc(N)c2)nc1)NC(=O)C1(NC(=O)C(SC(C)=O)C(C)C)CCCC1>>CCOC(=O)C(Cc1ccc(-c2cccc(NC(C)=O)c2)nc1)NC(=O)C1(NC(=O)C(SC(C)=O)C(C)C)CCCC1,,C1CCOC1,,,,val
US04734357,CCCCCCCCCCCCCCOc1ccccc1NC(=O)c1cc(Sc2nnnn2-c2cccc(C(=O)OCC)c2)c2ccccc2c1O>>CCCCCCCCCCCCCCOc1ccccc1NC(=O)c1cc(Sc2nnnn2-c2cccc(C(=O)O)c2)c2ccccc2c1O,,CO,O,Cl,[K+].[OH-],val
US20120329808A1,C[C@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncnc2c1[C@H](C)SC2>>C[C@H]1CNCCN1c1ncnc2c1[C@H](C)SC2,,ClCCl,,Cl,,val
US05902713,CS(=O)(=O)Cl.N#CC(=NO)c1ccccc1>>CS(=O)(=O)ON=C(C#N)c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US06020345,CN.Cc1ccc(CO)nc1Cl>>CNc1nc(CO)ccc1C,,CCO,,,,val
US20110230458A1,CC(C)(C)OC(=O)N1C[C@@H](CO)[C@H](CO)C1.CCCCc1nnc(Cl)cc1-c1ccc(OCc2ccccc2)cc1>>CCCCc1nnc(OC[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CO)cc1-c1ccc(OCc2ccccc2)cc1,,C1CCOC1,,O,[H-].[Na+],val
US20100190764A1,CCOC(=O)C1CCN(C2CCC3(C2)C(=O)c2cc(Cl)ccc2Oc2ccccc23)CC1>>O=C(O)C1CCN(C2CCC3(C2)C(=O)c2cc(Cl)ccc2Oc2ccccc23)CC1,,CCO,O,[K+].[OH-],,val
US20090215776A1,Brc1cn[nH]c1.CC1(C)OB(c2cnn(C3CCOCC3)c2)OC1(C)C>>Brc1cnn(C2CCOCC2)c1,,CN(C)C=O,,[H-].[Na+],,val
US04933350,COC(=O)C(c1ccccc1)N(CC(OC)OC)C(=O)C(C)C>>COC(CN(C(=O)C(C)C)C(C(=O)O)c1ccccc1)OC,,CO,O,[Na+].[OH-],,val
US05651919,BrC(Br)(Br)Br.OCc1ccc(-c2ccc(F)c(F)c2)cc1>>Fc1ccc(-c2ccc(CBr)cc2)cc1F,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05405997,C=CCCCCCCBr.O=[O+][O-]>>O=CCCCCCCBr,,CO,ClCCl,,,val
US20140005222A1,COC(=O)c1ccc(C)c(NC(=O)c2nc(N3CCCC(CO[Si](C)(C)C(C)(C)C)C3)ccc2C)c1C>>COC(=O)c1ccc(C)c(NC(=O)c2nc(N3CCCC(CO)C3)ccc2C)c1C,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150175557A1,CC(C)(C)OC(=O)NCc1cncnc1C(C)(C)F.Cl.ClCCl>>CC(C)(F)c1ncncc1CN.Cl.Cl,,ClCCl,,,,val
US20120252805A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(NS(=O)(=O)c2ccccc2)c2c(Br)c(-c3cn[nH]c3)sc2n1>>Cc1cc(NS(=O)(=O)c2ccccc2)c2c(Br)c(-c3cnn(C(=O)OC(C)(C)C)c3)sc2n1,CN(C)c1ccncc1,CC#N,,CCN(CC)CC,,val
US20130053366A1,C#Cn1c2c(c3cc(C)ccc31)CN(C)CC2.NS(=O)(=O)c1ccc(Br)cc1>>Cc1ccc2c(c1)c1c(n2C#Cc2ccc(S(N)(=O)=O)cc2)CCN(C)C1,,O,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20060183732A1,CNC1CC1.COC(=O)OC/C=C/c1ccc(F)cc1.C[C@@H](c1ccccc1)N([C@@H](C)c1ccccc1)p1oc2ccc3ccccc3c2c2c(ccc3ccccc32)o1>>C=C[C@H](NCC1CC1)c1ccc(F)cc1,,C1CCOC1,CCO,Cc1ccc(S(=O)(=O)O)cc1,,val
US20010029299A1,CNCCOc1ccc([N+](=O)[O-])cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CN(CCOc1ccc([N+](=O)[O-])cc1)C(=O)C(F)(F)F,,ClCCl,,Cl,c1ccncc1,val
US04268678,CCC(=O)C(CCCCOc1ccc(OC)cc1Cl)C(=O)CC.NO>>CCc1noc(CC)c1CCCCOc1ccc(OC)cc1Cl,,c1ccncc1,,Cl,,val
US20070037821A1,CC(C)(C)OC(=O)N[C@@H](CCC(=O)OCCCN1CCN(C(=O)OCc2ccccc2)CC1)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@@H](CCC(=O)OCCCN1CCNCC1)C(=O)OC(C)(C)C,[Pd],CCO,,,,val
US06228865B1,CCOC(=O)CC1=CCOCC1>>CCOC(=O)CC1CCOCC1,,CCOC(C)=O,,,,val
US05157041,CC(C)(C)N1CCC[C@@]1(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cncn1C(=O)OCc1ccccc1)NC(=O)OCc1ccccc1)C(N)=O.N#N>>CC(C)(C)N1CCC[C@@]1(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)OCc1ccccc1)C(N)=O.N#N,,Cl,,[Na+].[OH-],,val
US20100210591A1,CCOC(=O)CC=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccc([N+](=O)[O-])cc1F>>CCOC(=O)/C(C)=C/c1ccc([N+](=O)[O-])cc1F,,Cc1ccccc1,,CCCCCCC,,val
US20130281434A1,COC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(N3CC(c4ccc5c(cnn5C)c4)CC3=O)sc2c1-c1ccc(Cl)cc1.[OH-]>>Cc1cc2nc(NCC(CC(=O)O)c3ccc4c(cnn4C)c3)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O,,C1CCOC1,CO,Cl,,val
US20140315886A1,N#Cc1cccnc1.Nc1ccc(Cl)cc1C(=O)C(F)(F)F>>FC(F)(F)c1nc(-c2cccnc2)nc2ccc(Cl)cc12,,C1COCCO1,Cl,,,val
US20120088767A1,Nc1c([N+](=O)[O-])cc(Br)cc1[N+](=O)[O-]>>Nc1cc(Br)cc([N+](=O)[O-])c1N,,CCO,,,,val
US20120016014A1,COc1ccc(CN)cc1.O=C(O)c1sc2ccccc2c1Br>>COc1ccc(CNC(=O)c2sc3ccccc3c2Br)cc1,,CCOC(C)=O,CN(C)C=O,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20090048239A1,COCOc1cc(OC)ccc1-c1[nH]c2cc(C(=O)OC)ccc2c1C1CCCCC1>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc(OC)cc3O)[nH]c2c1,,CO,,Cl,,val
US20090048295A1,COc1cc(Cl)nc2c1C(O)CCC2.O=S(Cl)Cl>>COc1cc(Cl)nc2c1C(Cl)CCC2,,ClCCl,,,,val
US20110136802A1,CN.COc1cc2c(c(C(=O)O)c1)[C@]1(C)CC[C@H]3C(C)(C)CCC[C@]3(C)[C@H]1CS2>>CNC(=O)c1cc(OC)cc2c1[C@]1(C)CC[C@H]3C(C)(C)CCC[C@]3(C)[C@H]1CS2,,C1CCOC1,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120010228A1,CC(C)(C)OC(=O)c1ccccc1CN1CN(c2ccc(F)cc2)C2(CCN(CCCN3C(=O)C(C)(F)c4ccccc43)CC2)C1=O>>CC1(F)C(=O)N(CCCN2CCC3(CC2)C(=O)N(Cc2ccccc2C(=O)O)CN3c2ccc(F)cc2)c2ccccc21,,C1COCCO1,,Cl,,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(Oc3cnccn3)cc(O)c21>>O=C(O)CC1OB(O)c2cc(Oc3cnccn3)cc(O)c21,,CCO,O,Cl,[Li+].[OH-],val
US04175130,CCBr.Cc1ccc(C)c(Oc2oc(-c3ccc(Cl)cc3)nc2CC(=O)O)c1>>CCOC(=O)Cc1nc(-c2ccc(Cl)cc2)oc1Oc1cc(C)ccc1C,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,O,val
US20080188500A1,Cc1ccc(N)cc1-c1ccc2[nH]c3ncncc3c2c1.O=C=Nc1cccc(C(F)(F)F)c1>>Cc1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2[nH]c3ncncc3c2c1,,C1CCOC1,CO,CCN(C(C)C)C(C)C,,val
US20060241302A1,CC(C)(C)OC(=O)NCCN.Fc1ccc(F)c(C(Sc2ccc(Cl)cc2)c2cc(Cl)ncc2Cl)c1>>CC(C)(C)OC(=O)NCCNc1cc(C(Sc2ccc(Cl)cc2)c2cc(F)ccc2F)c(Cl)cn1,,C1COCCO1,,,,val
US20020019527A1,CC(C)(C)OC(=O)NCCN(C(=O)CCl)c1cccc(OC(F)(F)F)c1>>CC(C)(C)OC(=O)N1CCN(c2cccc(OC(F)(F)F)c2)C(=O)C1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070185111A1,CN(C)CC(C)(C)CN.CS(=O)(=O)c1nccc(-c2cccnc2Oc2ccc(Nc3nnc(-c4ccccc4)c4ccccc34)cc2)n1>>CN(C)CC(C)(C)CNc1nccc(-c2cccnc2Oc2ccc(Nc3nnc(-c4ccccc4)c4ccccc34)cc2)n1,,CS(C)=O,,,,val
US20100292482A1,CN(C)C=CC=O.N#CCC(=O)C(F)(F)F>>CN(C)C=CC=C(C#N)C(=O)C(F)(F)F,,ClCCl,,CC(=O)OC(C)=O,,val
US04031226,O=C(c1ccccc1Br)N1CC1.OC1(c2ccc(Cl)cc2)CCNCC1>>O=C(NCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br,,CO,,c1ccccc1,,val
US20090197863A1,CNC.COC(=O)c1cccc2oc(-c3ccc(CBr)cc3)nc12>>COC(=O)c1cccc2oc(-c3ccc(CN(C)C)cc3)nc12,,CCO,,,,val
US20130137675A1,CC1(C)OB(c2ccnn2-c2ccccc2)OC1(C)C.O=c1cnn(-c2cccc(C(F)(F)F)c2)cc1OS(=O)(=O)C(F)(F)F>>O=c1cnn(-c2cccc(C(F)(F)F)c2)cc1-c1ccnn1-c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20060142362A1,CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)Cc2csc(NC(=O)c3ccc(Cl)cc3)n2)c(F)c1>>NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)Cc2csc(NC(=O)c3ccc(Cl)cc3)n2)c(F)c1,,CO,ClC(Cl)Cl,Cl,,val
US20050070559A1,COC(=O)c1ccc2c(c1)CC(=O)N2.COCCOc1ccc2c(Cl)ncnc2c1>>COCCOc1ccc2c(-c3c(O)[nH]c4ccc(C(=O)OC)cc34)ncnc2c1,,C1CCOC1,CN1CCCC1=O,[H-].[Na+],,val
US20090181989A1,CSc1nc(-c2ccc(Cl)cc2Cl)c2ncn(C3CCCCO3)c2n1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc(-c2ccc(Cl)cc2Cl)c2[nH]cnc2n1,,ClCCl,,,,val
US20080318941A1,CN1CCC(=O)CC1.O=C(N(C(=O)C(F)(F)F)c1ccccc1)C(F)(F)F>>CN1CC=C(OC(=O)C(F)(F)F)CC1,,C1CCOC1,CCOC(C)=O,CC(C)NC(C)C,[Li]CCCC,val
US20040006114A1,CCS(=O)(=O)Cl.N#Cc1ccc(-c2ccc(N)cc2)cc1>>CCS(=O)(=O)Nc1ccc(-c2ccc(C#N)cc2)cc1,,ClCCl,,,,val
US20100056788A1,COC(=O)c1ccc(Cl)nc1Cl.OB(O)c1ccccc1>>COC(=O)c1ccc(-c2ccccc2)nc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20130289081A1,COC(=O)c1ccc[n+]([O-])c1N>>Nc1c(C(=O)O)ccc[n+]1[O-],,CCO,,[Na+].[OH-],,val
US20100152235A1,Cc1c(-c2noc(-c3ccc(OC(C)C)c(Cl)c3)n2)ccc2c1CCN(C(=O)OC(C)(C)C)C2.O=C(O)C(F)(F)F>>Cc1c(-c2noc(-c3ccc(OC(C)C)c(Cl)c3)n2)ccc2c1CCNC2.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05231102,COC(=O)Cc1ccc(CCNC(=O)OC(C)(C)C)cc1>>CC(C)(C)OC(=O)NCCc1ccc(CC(=O)O)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US04517003,ClP(Cl)(Cl)(Cl)Cl.NC(=O)C(Cl)Cl.O=CO>>O=C(NP(=O)(Cl)Cl)C(Cl)Cl,,ClC(Cl)(Cl)Cl,,,,val
US20140140956A1,BrP(Br)Br.COc1cc(OC)c2c(=O)[nH]c(-c3ccc(OCCO)c(-c4ccc(S(C)=O)cc4)n3)nc2c1>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(OCCBr)c(-c4ccc(SC)cc4)n3)nc2c1,,CN(C)C=O,,,,val
US20080261941A1,CC(C)(C)OC(=O)N1CCC(=Cc2cc(Oc3ccc(C(F)(F)F)cn3)cc(C3CC3)c2)CC1>>FC(F)(F)c1ccc(Oc2cc(C=C3CCNCC3)cc(C3CC3)c2)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020055510A1,CO[C@@H]1[C@@H](CO)O[C@@H](n2c3c(Cl)cccc3c3c4c(c5c6cccc(Cl)c6[nH]c5c32)C(=O)NC4=O)[C@H](O)[C@H]1O.Cc1ccc(S(=O)(=O)Cl)cc1>>CO[C@@H]1[C@@H](CO)O[C@@H](n2c3c(Cl)cccc3c3c4c(c5c6cccc(Cl)c6[nH]c5c32)C(=O)NC4=O)[C@H](OS(=O)(=O)c2ccc(C)cc2)[C@H]1O,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20110118262A1,CC(C)(C)OC(=O)N1CC=C(c2ccc(C(=O)O)cc2C(F)(F)F)CC1>>CC(C)(C)OC(=O)N1CCC(c2ccc(C(=O)O)cc2C(F)(F)F)CC1,[Pd],CO,,,,val
US05932582,Cc1cc(O)ccc1NC(=O)OC(C)(C)C.NC(=O)CBr>>Cc1cc(OCC(N)=O)ccc1NC(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110224195A1,COC(=O)CCC[N+](=O)[O-].NCCc1ccccc1F.O=Cc1cc(F)ccc1F>>O=C1CC[C@@H]([N+](=O)[O-])[C@H](c2cc(F)ccc2F)N1CCc1ccccc1F,,CCO,,CC(=O)O,CC(=O)[O-].[Na+],val
US20070021482A1,C1COCCN1.FC(F)(F)c1cc(-c2cccc(CCl)c2)c2c(c1)ncn2-c1ccccc1>>FC(F)(F)c1cc(-c2cccc(CN3CCOCC3)c2)c2c(c1)ncn2-c1ccccc1,,CN1CCCC1=O,,,,val
US20090042896A1,CC(=O)[C@H]1CN(Cc2ccccc2)C[C@@H]1c1ccc(F)c(Cl)c1>>C[C@@H](O)[C@H]1CN(Cc2ccccc2)C[C@@H]1c1ccc(F)c(Cl)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150031708A1,COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1C.Cc1cc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc(Cl)c1C>>COc1ncc(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)cc(C)c2C)cc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US04388104,CC1=CCCC(C(C)O)O1.O=C(OO)c1cccc(Cl)c1>>CC1OC2(C)OC1CCC2O,,ClCCl,,,,val
US20150232460A1,COC(=O)c1ncccc1C1CC1>>O=C(O)c1ncccc1C1CC1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20070072873A1,COC(=O)c1cscc1NC(=O)COc1ccc(-c2ccccc2OC)cn1>>COc1ccccc1-c1ccc(OCC(=O)Nc2cscc2C(=O)O)nc1,,CCO,,[Na+].[OH-],,val
US20040192688A1,ClCCOc1ccc2ccccc2c1.NC1CCCCC1>>c1ccc2cc(OCCNC3CCCCC3)ccc2c1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090029976A1,COc1ccc(Cl)c(OC)c1.O=C(Cl)c1ccc(F)cc1>>COc1cc(OC)c(C(=O)c2ccc(F)cc2)cc1Cl,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080085906A1,Cc1cnc(Oc2ccccc2)c(Br)c1.OB(O)c1ccc(Cl)cc1>>Cc1cnc(Oc2ccccc2)c(-c2ccc(Cl)cc2)c1,,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20060264428A1,C[C@H](c1ccccc1)N1C[C@](C)(C(=O)OC(C)(C)C)C(O)C1=O>>C[C@H](c1ccccc1)N1CC(O)[C@@](C)(C(=O)OC(C)(C)C)C1,,C1CCOC1,,B,,val
US06388104B1,CC(=O)CCl.OCC(O)CCl>>CC1(CCl)OCC(CCl)O1,Cc1ccc(S(=O)(=O)O)cc1,C1CCCCC1,,O,,val
US05849757,CCOC(=O)CC(=O)C1(NC(=O)OC(C)(C)C)CCC1>>CCOC(=O)CC(O)C1(NC(=O)OC(C)(C)C)CCC1,,CCO,,O,[BH4-].[Na+],val
US20100029629A1,C1CCNC1.CCOC(=O)Cc1c[nH]c2cccnc12>>O=C(Cc1c[nH]c2cccnc12)N1CCCC1,,C1CCOC1,CCO,CCN(CC)CC,,val
US20020019390A1,CON=C1CCCc2ccc([N+](=O)[O-])cc21>>CON=C1CCCc2ccc(N)cc21,[Pd],CO,,,,val
US20130040930A1,Cc1cnc(N2CCN(C(=O)c3ccc(N4CCNC4=O)cc3F)CC2)c(C)c1.Cl>>Cc1cnc(N2CCN(C(=O)c3ccc(N4CCNC4=O)cc3F)CC2)c(C)c1.Cl,,CO,ClC(Cl)Cl,CCO,,val
US20150166549A1,CC(O)c1oc(=O)c2ccccc2c1Br.OB(O)c1ccccc1>>CC(O)c1oc(=O)c2ccccc2c1-c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050187223A1,CC(NC(=O)OC(C)(C)C)c1ccc(CCN)cc1.CS(=O)(=O)c1nccc(N2CCC(=O)N3CC=C(c4ccccc4)N=C32)n1>>CC(NC(=O)OC(C)(C)C)c1ccc(CCNc2nccc(N3CCC(=O)N4CC=C(c5ccccc5)N=C43)n2)cc1,,CN1CCCC1=O,,C1COCCO1,,val
US20040259950A1,CCOC(=O)C=Cc1ccccc1OCC>>CCOC(=O)C(Cc1ccccc1)OCC,[Pd],,,CCO,[H][H],val
US20020143035A1,O=C1[C@@H]2C[C@@H](O)CN2C(=O)N1c1cc(Cl)cc(Cl)c1.Oc1ccc(Br)cc1>>O=C1[C@@H]2C[C@H](Oc3ccc(Br)cc3)CN2C(=O)N1c1cc(Cl)cc(Cl)c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090137607A1,CCOC(=O)C(C(=O)OCC)c1ccccc1.COC(=O)c1cc(N)n[nH]1>>COC(=O)c1cc2nc(O)c(-c3ccccc3)c(O)n2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20040110832A1,CC(C)N=C=NC(C)C.CN(C)C=O.CN(C)c1ccncc1.O=C(O)c1ccc(F)c([N+](=O)[O-])c1.O=C(O)c1ccc(Oc2cccc(C(F)(F)F)c2)c([N+](=O)[O-])c1.Oc1cccc(C(F)(F)F)c1.On1nnc2ccccc21>>O=C(N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)O)c1ccc(Oc2cccc(C(F)(F)F)c2)c([N+](=O)[O-])c1.O=C(O)c1ccc(Oc2cccc(C(F)(F)F)c2)c([N+](=O)[O-])c1,CN(C)c1ccncc1,CN(C)C=O,,,,val
US20140154179A1,CCC(=O)CBr.O=C(c1ccc[nH]1)C(Cl)(Cl)Cl>>CCc1cn2cccc2c(=O)o1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100130558A1,CC(C)C(C(=O)N[C@H]1CC[C@@H]2CNC[C@H]12)c1ccccc1.O=C(Cl)c1ccccc1>>CC(C)C(C(=O)N[C@H]1CC[C@@H]2CN(C(=O)c3ccccc3)C[C@H]12)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20120232081A1,CC(C)(C)OC(=O)N1CCNCC1.Cc1c(F)cccc1Cc1cn2ccccc2c1-c1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1c(F)cccc1Cc1c(-c2ccccc2)c2ccccn2c1C(=O)N1CCN(C(=O)OC(C)(C)C)CC1,,Cl,ClCCl,CCN(CC)CC,c1ccncc1,val
US20150291595A1,Cc1ccn2nc([C@H](C)N)n(-c3ccccc3)c(=O)c12.Clc1ncnc2sccc12>>Cc1ccn2nc([C@H](C)Nc3ncnc4sccc34)n(-c3ccccc3)c(=O)c12,,CCCCO,,CCN(C(C)C)C(C)C,,val
US05430062,COc1cc(C=Nc2ccc(C)cc2)cc(OC)c1OC>>COc1cc(CNc2ccc(C)cc2)cc(OC)c1OC,,CCO,,[BH4-].[Na+],,val
US20130345192A1,CC(C)(C)OC(=O)N1CCC[C@H](Oc2ncnc3[nH]ccc23)C1.Cl>>Cl.c1nc(O[C@H]2CCCNC2)c2cc[nH]c2n1,,C1COCCO1,,,,val
US20050215575A1,N#Cc1ccc(-c2ncccc2C(F)(F)F)nc1N.O=S(=O)(O)O>>NC(=O)c1ccc(-c2ncccc2C(F)(F)F)nc1N,,O=S(=O)(O)O,,[Na+].[OH-],,val
US20090131458A1,Clc1nc(Cl)c2[nH]cnc2n1.OCC1CCOCC1>>Clc1nc(Cl)c2ncn(CC3CCOCC3)c2n1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20010056123A1,CC(C)(C)OC(=O)NCCOc1cc(C#N)ccc1OCc1ccccc1.Cl>>Cl.N#Cc1ccc(OCc2ccccc2)c(OCCN)c1,,C1COCCO1,,,,val
US20060106016A1,COc1ccc(COCC=CCOC(=O)C=[N+]=[N-])cc1>>COc1ccc(COC[C@H]2[C@@H]3COC(=O)[C@H]23)cc1,,ClCCl,,,,val
US08222435B2,C=C1OCCO1.CCC(=O)C(=O)Cl.O>>CCOC(=O)C(=O)/C=C1\COCO1,,ClCCl,,c1ccncc1,,val
US20150018341A1,CC/C(=C(\c1ccc(O)cc1)c1ccc(Cl)nc1)c1ccccc1.CNCCS>>CC/C(=C(\c1ccc(O)cc1)c1ccc(SCCNC)nc1)c1ccccc1,,C1CCOC1,,Cl,[H-].[Na+],val
US20100249094A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)ccc3C)c(F)c12.NC1(c2cccnn2)CC1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5cccnn5)CC4)ccc3C)c(F)c12,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20110003787A1,CC(C)(C)OC(=O)n1cccc1-c1nc(C(O)CO)cs1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)n1c(Br)ccc1-c1nc(C(O)CO)cs1,,C1CCOC1,,O,,val
US20150018363A1,CCOC(=O)c1nc(C(F)F)cs1>>OCc1nc(C(F)F)cs1,,CO,,[BH4-].[Na+],,val
US07005440B1,COC(=O)CC(=O)C(C)Br.NC(=O)c1ccccc1>>COC(=O)Cc1nc(-c2ccccc2)oc1C,,Cc1ccccc1,,,,val
US20110237784A1,CC(=O)c1cccc(O)c1.Cc1ccccc1[Mg]Cl>>Cc1ccccc1C(C)(O)c1cccc(O)c1,,C1CCOC1,,,,val
US20120172333A1,CCOC(=O)c1c(N)ccn1-c1ccc(Br)cc1.O=C(Cl)Cc1ccccc1>>CCOC(=O)c1c(NC(=O)Cc2ccccc2)ccn1-c1ccc(Br)cc1,,ClCCl,,CCN(CC)CC,,val
US20120077793A1,CC(C)OC(=O)N1CCC(O)CC1.Oc1ccc(Br)cc1>>CC(C)OC(=O)N1CCC(Oc2ccc(Br)cc2)CC1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060116383A1,CCOC(=O)CC(c1ccccc1)n1cnc2cc(C(=O)O)ccc21.Nc1ccccc1>>CCOC(=O)CC(c1ccccc1)n1cnc2cc(C(=O)Nc3ccccc3)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20060293519A1,COCCOc1nc(C)cc(OCC(F)(F)F)c1N.O=C(Br)CBr>>COCCOc1nc(C)cc(OCC(F)(F)F)c1NC(=O)CBr,,ClCCl,,CN(C)c1ccccc1,,val
US20110172193A1,CN(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O.COc1c(N2CCCC(=C(F)CN)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12>>COc1c(N2CCCC(=C(F)CNC(=O)[C@H](CN(C)C)NC(=O)OC(C)(C)C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050176742A1,CCOC(=O)c1c(NC(C)=O)sc2c1CCC(Cc1ccccc1)C2.O>>CCOC(=O)c1c(NC(C)=O)sc2c1CCC(Cc1ccccc1)C2=O,,O,,CC(=O)O,,val
US20060128793A1,CC(C)(C)NCCO.COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CC[C@H](O)[C@@]2(C)C[C@H]1OC(C)=O>>COC[C@H]1OC(=O)/C(=C/N(CCO)C(C)(C)C)C2=C(O)C(=O)C3=C([C@H](OC(C)=O)C[C@@]4(C)C3CC[C@@H]4O)[C@]21C,,ClCCl,,,,val
US20060142577A1,CCNc1cc(C(=O)OC)cc(C(F)(F)F)c1>>CCNc1cc(C(=O)O)cc(C(F)(F)F)c1,,CCO,,[Na+].[OH-],,val
US04122179,CC(C)(C)C(=O)O.CC[C@@]12C=C(C(=O)OC)n3c4c(c5ccccc53)CCN(CCC1)[C@H]42>>CC(C)(C)C(=O)[O-].CC[C@@]12C=C(C(=O)OC)n3c4c(c5ccccc53)CCN(CCC1)[C@H]42,,O,,,,val
US05736548,CCc1nn(C2CCCC2)c(N)c1C(N)=O.CN1CCCCC(Oc2cccc(C=O)c2)C1>>CCc1[nH]n(C2CCCC2)c2nc(-c3cccc(OC4CCCCN(C)C4)c3)nc(=O)c1-2,,ClCCl,,CS(=O)(=O)O,,val
US05910498,Cc1ccc(S(=O)(=O)O)cc1.Nc1cc(-n2cc(C(=O)O)c(=O)c3cc(F)c(N4CC(N)C4)c(Cl)c32)c(F)cc1F>>Cc1ccc(S(=O)(=O)O)cc1.Nc1cc(-n2cc(C(=O)O)c(=O)c3cc(F)c(N4CC(N)C4)c(Cl)c32)c(F)cc1F,,CCOCC,,CN(C)C=O,O,val
US20120010191A1,CC(=O)OCc1c(B2OC(C)(C)C(C)(C)O2)cccc1N1CCn2c(cc3c2CCCC3)C1=O.Cn1cc(Br)nc(Nc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3)c1=O>>CC(=O)OCc1c(-c2cn(C)c(=O)c(Nc3ccc4c(c3)CCN(C(=O)OC(C)(C)C)C4)n2)cccc1N1CCn2c(cc3c2CCCC3)C1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20160096839A1,OB(O)c1cccc(Cl)c1F.Oc1cc(Cl)ncn1>>Oc1cc(-c2cccc(Cl)c2F)ncn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,CCN(C(C)C)C(C)C,,val
US20090221645A1,CC[Mg]Cl.COCNC(=O)c1ccc2cc(Cl)ccc2c1>>CCC(=O)c1ccc2cc(Cl)ccc2c1,,CO,,C1CCOC1,Cl,val
US20080176830A1,O=C1CCc2cc(-c3ccc(C(F)(F)F)cc3)cc([N+](=O)[O-])c2N1>>Nc1cc(-c2ccc(C(F)(F)F)cc2)cc2c1NC(=O)CC2,[Pd],CCO,,[H][H],,val
US20090156600A1,CCC(=O)C(Cc1ccc(S(=O)(=O)CC)cc1)C(=O)OC.COC(=O)COc1ccc(F)c(N)c1>>CCc1[nH]c2c(F)ccc(OCC(=O)OC)c2c(=O)c1Cc1ccc(S(=O)(=O)CC)cc1,,O,,C1COCCO1,,val
US20090111823A1,COC(=O)c1ccc(N(C)C)nc1.NN>>CN(C)c1ccc(C(=O)NN)cn1,,CCO,,O,,val
US20070021604A1,O=C1CCCCCN1.O=[N+]([O-])O>>O=C1CCCCCN1.O=[N+]([O-])O,,O,,,,val
US06380238B1,COC(=O)C(=Cc1ccc(Cl)c(F)c1)N=[N+]=[N-]>>COC(=O)c1cc2ccc(Cl)c(F)c2[nH]1,,Cc1ccccc1C,,,,val
US20010011135A1,O=C(O)c1cccc(Oc2ccc([N+](=O)[O-])cc2)c1>>Nc1ccc(Oc2cccc(C(=O)O)c2)cc1,[Pd],CO,,,,val
US20130090480A1,CCc1ccc(Nc2nc3cc(N)ccc3o2)cc1.O=C(Cl)Cc1ccccc1>>CCc1ccc(Nc2nc3cc(NC(=O)Cc4ccccc4)ccc3o2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20080248511A1,CCCCI.COc1ccc(CNC(=O)/C=C/c2ccc3[nH]cc(CCN(C)C)c3c2)cc1>>CCCC[N+](C)(C)CCc1c[nH]c2ccc(/C=C/C(=O)NCc3ccc(OC)cc3)cc12.[I-],,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20110190490A1,CCCOc1nc(Cc2ccc(Cl)cc2)nc2oc(-c3cc(C)c(OC)c(C)c3)nc12>>CCCOc1nc(Cc2ccc(Cl)cc2)nc2oc(-c3cc(C)c(O)c(C)c3)nc12,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20090137553A1,CN.COC(=O)C1CN(c2cc(F)c(N3CCCS(=O)(=O)CC3)c(F)c2)C(=O)O1>>CNC(=O)C1CN(c2cc(F)c(N3CCCS(=O)(=O)CC3)c(F)c2)C(=O)O1,,CO,,CCN(CC)CC,Cl,val
US05344845,C=CCOC(=O)C1(C)CCC(OC(=O)/C=C\c2ccc(OC(C)=O)c(OC)c2)CC1>>C=CCOC(=O)C1(C)CCC(OC(=O)/C=C\c2ccc(O)c(OC)c2)CC1,,CO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20040106645A1,CS(=O)(=O)Cl.OCCCN1CCCCC1>>CS(=O)(=O)OCCCN1CCCCC1,,ClCCl,,CCN(CC)CC,,val
US20140228387A1,COc1cc(F)ccc1B(O)O.Fc1cnc(Cl)nc1Cl>>COc1cc(F)ccc1-c1nc(Cl)ncc1F,,CCOC(C)=O,COCCOC,O=C([O-])[O-].[K+].[K+],,val
US20100216746A1,CN(C)Cc1cc(C#N)cc(Oc2c(Cl)ccc(CNC(=O)c3c(Cl)ncn3COCC[Si](C)(C)C)c2F)c1.O=C(O)C(F)(F)F>>CN(C)Cc1cc(C#N)cc(Oc2c(Cl)ccc(CNC(=O)c3[nH]cnc3Cl)c2F)c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20160145206A1,N#Cc1cc(Cl)ccc1-c1ccc(S(=O)(=O)O)cc1.O=S(Cl)Cl>>N#Cc1cc(Cl)ccc1-c1ccc(S(=O)(=O)Cl)cc1,CN(C)C=O,Cc1ccccc1,,,,val
US05786374,CCC(=NOC(C)=O)c1ccccc1O>>CCc1noc2ccccc12,,c1ccncc1,,Cl,,val
US20140045819A1,C=CC(=O)OCC.Nc1cc(Cl)ccc1I>>O=C1CCc2ccc(Cl)cc2N1,,CS(C)=O,O,CC(C)(C#N)N=NC(C)(C)C#N,,val
US04041169,CC(C)=O.CCOC(=O)C(=O)c1c[nH]c2ccc(OCc3ccccc3)cc12.OCCc1c[nH]c2ccccc12>>CC1(C)OCCc2c1[nH]c1ccc(OCc3ccccc3)cc21,,CC(C)=O,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150105373A1,CI.COCC(NC(=O)N1CC(=O)N(COCC[Si](C)(C)C)c2cc(O)cnc21)c1ccc(OC(F)(F)F)cc1>>COCC(NC(=O)N1CC(=O)N(COCC[Si](C)(C)C)c2cc(OC)cnc21)c1ccc(OC(F)(F)F)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070208007A1,CCCN(CCC)CCCCN(Cc1ccc(CN(Cc2nccn2C)Cc2nccn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1)Cc1nnnn1C1CCCCO1>>CCCN(CCC)CCCCN(Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1)Cc1nnn[nH]1,,CO,,Cl,,val
US20070155805A1,CCOC(=O)/C=C/c1sc2ccc(C(F)(F)F)cc2c1C>>CCOC(=O)CCc1sc2ccc(C(F)(F)F)cc2c1C,[Pd],CCO,,,,val
US20040018942A1,Cn1c(C(F)(F)F)cc(=O)n(-c2cc(C(=O)O)c(Cl)cc2F)c1=O.O=C(Cl)C(=O)Cl>>Cn1c(C(F)(F)F)cc(=O)n(-c2cc(C(=O)Cl)c(Cl)cc2F)c1=O,CN(C)C=O,ClC(Cl)Cl,,,,val
US04511573,COC(=O)CP(=O)(OC)OC.Cn1c(-c2cccnc2)c(CCCCCC=O)c2ccccc21>>COC(=O)C=CCCCCCc1c(-c2cccnc2)n(C)c2ccccc12,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20040044195A1,CCCCCCCCCCCCCCCCCCOc1ccccc1Br.O=C(c1ccccc1)c1ccccc1>>CCCCCCCCCCCCCCCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,Cl,[Mg],val
US20040053979A1,CCCOC(Cc1ccc2c(ccn2COCC[Si](C)(C)C)c1)C(=O)OCC>>CCCOC(Cc1ccc2c(ccn2COCC[Si](C)(C)C)c1)C(=O)O,,C1COCCO1,,[Li+].[OH-],,val
US05821253,COc1ccc(C2=C(C(=O)c3ccc(OCCN4CCCCC4)cc3)c3ccc(OC)cc3CC2)cc1>>COc1ccc(C2=C(C(O)c3ccc(OCCN4CCCCC4)cc3)c3ccc(OC)cc3CC2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130184253A1,C/C=C/c1nc(-c2c(CC)cccc2CC)cc(C)c1C(=O)OC>>CCc1cccc(CC)c1-c1cc(C)c2c(n1)CC(C)OC2=O,,O,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20110178053A1,O=C1CCC(=O)N1I.c1cncc(-c2cc3c(cn2)[nH]c2ncccc23)c1>>Ic1cnc2[nH]c3cnc(-c4cccnc4)cc3c2c1,,CC(=O)O,,,,val
US20030087901A1,COC(=O)Cc1ccc(OCCBr)cc1>>O=C(O)Cc1ccc(OCCBr)cc1,,O,,CO,[Na+].[OH-],val
US20070260041A1,FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CCS.OCC=CCCl>>OCC=CCSCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,,CCO,,C,C[O-].[Na+],val
US20060025433A1,CC(C)(C)OC(=O)NC1CCC(CNc2nc(Cl)ncc2[N+](=O)[O-])CC1.CNc1cccnc1OC(C)C>>CC(C)Oc1ncccc1CNc1ncc([N+](=O)[O-])c(NCC2CCC(NC(=O)OC(C)(C)C)CC2)n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US08450525B2,COC(=O)/C=C/c1ccc(C=C(CO)c2ccc(F)cc2)cc1>>COC(=O)C=Cc1ccc(/C=C(/C=O)c2ccc(F)cc2)cc1,,CCOCC,ClCCl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20030092677A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc(I)cc1[N+](=O)[O-]>>CC(C)(C)OC(=O)Nc1ccc(I)cc1[N+](=O)[O-],,CCC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150183791A1,CC(C)C[C@@H](CO)N1C(=O)c2ccccc2C1=O.Oc1cc(Br)ccn1>>CC(C)C[C@@H](Cn1ccc(Br)cc1=O)N1C(=O)c2ccccc2C1=O,,C1CCOC1,CCOC(C)=O,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140113882A1,CN(C)[C@@H](Cc1ccccc1)CN1C(=O)c2ccccc2C1=O>>CN(C)[C@H](CN)Cc1ccccc1,,CO,,NN,O,val
US20150038437A1,BrCc1ccccc1.O=C(O)c1c(Cl)ccnc1Cl>>O=C(OCc1ccccc1)c1c(Cl)ccnc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06100283,CI.COc1ccc(-c2nc3cccc(C(N)=O)c3[nH]2)cc1>>COc1ccc(-c2nc3c(C(N)=O)cccc3n2C)cc1,,CC(C)=O,,[K+].[OH-],,val
US06380178B1,C=Cc1cccc(Cl)c1.ClCCl.O=C(O)C(F)(F)F>>O=CCCc1cccc(Cl)c1,,O=C(O)C(F)(F)F,,O,,val
US20080312322A1,COC(=O)COc1ccc(Cl)cc1C(=O)c1cc(Cl)ccc1OCC(=O)OCc1ccccc1>>O=C(O)COc1ccc(Cl)cc1C(=O)c1cc(Cl)ccc1OCC(=O)O,,CO,,[Na+].[OH-],,val
US06057329,COc1cc([N+](=O)[O-])cc(OC)c1[O-].OCCBr>>COc1cc([N+](=O)[O-])cc(OC)c1OCCO,,CN(C)C=O,,Cl,,val
US20090062259A1,NCCc1ccccn1.O=Cc1cccc(CCOC2CCCCO2)c1>>c1ccc(CCNCc2cccc(CCOC3CCCCO3)c2)nc1,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,O,,val
US04217279,C1=COCCC1.C1COCCO1.COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C>>C1CCC(OC2CCCCO2)OC1,Cc1ccc(S(=O)(=O)O)cc1,C1COCCO1,,CO,,val
US20090099176A1,COC(=O)C(Cc1ccc(Cl)cc1NC(=O)C(C)(C)C)NC(=O)OC(C)(C)C>>NC1Cc2ccc(Cl)cc2NC1=O,,C1CCOC1,,Cl,,val
US20090149441A1,CC(C)(O)c1ccc2nc(C(=O)Nc3ccc(F)cc3)cn2c1>>C=C(C)c1ccc2nc(C(=O)Nc3ccc(F)cc3)cn2c1,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)O)cc1,,val
US08471005B2,CCOC(=O)c1cccn1N.O=C(N=C=S)c1ccccc1>>CCOC(=O)c1cccn1NC(=S)NC(=O)c1ccccc1,,C1CCOC1,,CCOCC,,val
US20110071141A1,CCN.FC(F)(F)C1(c2cc(Cl)cc(Cl)c2)CC(c2ccc3c(c2)CCCN3)=NO1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCNC(=O)N1CCCc2cc(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)ccc21,,CCOC(C)=O,O,CCN(C(C)C)C(C)C,,val
US20150038437A1,CCCC(=NC(C)(C)C)c1ccc2c(c1)cc(CO[Si](C)(C)C(C)(C)C)n2C.COC(=O)C(C(=O)OC)C(=O)OC>>CCc1c(-c2ccc3c(c2)cc(CO[Si](C)(C)C(C)(C)C)n3C)[nH]c(=O)c(C(=O)OC)c1O,,c1ccc(Oc2ccccc2)cc1,,,,val
US06197766B1,CC(=O)OC(C)=O.O=C(Nc1ccc(C(F)(F)F)cc1)N1N=C(c2cccc(C(F)(F)F)c2)OCC1O>>CC(=O)OC1COC(c2cccc(C(F)(F)F)c2)=NN1C(=O)Nc1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(CC)CC,,val
US05036153,O=C(Cl)OCc1ccccc1.O=C(O)[C@@H]1CC(O)CN1>>O=C(O)[C@@H]1CC(O)CN1C(=O)OCc1ccccc1,,O,,O=C([O-])O.[Na+],,val
US05604237,BrCCCBr.CC(=O)Nc1ccc(O)cc1>>CC(=O)Nc1ccc(OCCCBr)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080214598A1,CC(C)(C)[SiH2]OC(C)(C)c1cc(CCO)ccc1Cl.CS(=O)(=O)Cl>>CC(C)(C)[SiH2]OC(C)(C)c1cc(CCOS(C)(=O)=O)ccc1Cl,,ClCCl,,CCN(CC)CC,,val
US06265411B1,CCOC(OCC)N1C(=O)Cc2cc(Br)ccc21.COCCOc1cc2ncnc(Cl)c2cc1OC>>CCOC(OCC)N1C(=O)C(c2ncnc3cc(OCCOC)c(OC)cc23)c2cc(Br)ccc21,,C1CCOC1,,[H-].[Na+],,val
US20090306066A1,CN(Cc1ccco1)c1nc(Cl)nc(NNC(=O)[C@H](CC2CCCC2)CN(C=O)OC2CCCCO2)c1F>>CN(Cc1ccco1)c1nc(Cl)nc(NNC(=O)[C@H](CC2CCCC2)CN(O)C=O)c1F,,CC(=O)O,O,,,val
US20110034469A1,CCO[C@@H]1C[C@@H]2CN(C(=O)[C@@H](NC(=O)[C@@H](C)N(C)C(=O)OC(C)(C)C)C3CCC(F)(F)CC3)[C@H](C(=O)N[C@@H]3CCOc4ccccc43)CN2C1>>CCO[C@@H]1C[C@@H]2CN(C(=O)[C@@H](NC(=O)[C@@H](C)NC)C3CCC(F)(F)CC3)[C@H](C(=O)N[C@@H]3CCOc4ccccc43)CN2C1,,CCOC(C)=O,Cl,,,val
US04895840,BrCCCc1ccccc1.CCN(CC)CCN.CO.O=C(O)C(=O)O>>CCN(CC)CCNCCCc1ccccc1.O.O=C(O)C(=O)O,,CC#N,CO,O=C([O-])[O-].[Na+].[Na+],,val
US20130244958A1,C1COCCN1.CC(Cl)OC(=O)Cl>>CC(Cl)OC(=O)N1CCOCC1,,ClCCl,,c1ccncc1,,val
US05278316,COC(=O)C(Cc1c[nH]c2ccccc12)NCOC(C)[Si](C)(C)C>>COC(=O)C(N)(CO)Cc1c[nH]c2ccccc12,,O=C(O)C(F)(F)F,,CCOC(C)=O,,val
US20150361101A1,CC(C)(C)OC(=O)n1c(B(O)O)cc2cc(F)ccc21.Oc1ccc(Cl)nc1I>>Oc1ccc(Cl)nc1-c1cc2cc(F)ccc2[nH]1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,O,O=C([O-])O.[Na+],,val
US08859714B1,CCCCCCCCCCC(CN)CCCCCCCC.O=c1oc(=O)c2ccsc2c2sccc12>>CCCCCCCCCCC(CCCCCCCC)Cn1c(=O)c2ccsc2c2sccc2c1=O,CN(C)c1ccncc1,CCOCC,,Cc1ccccc1,,val
US20160083387A1,C=C1[C@@H](OC(C)=O)C[C@H]2[C@H](CN=[N+]=[N-])[C@@H]([C@@]3(C)CC[C@H](OC(C)=O)C[C@@H]3COC(C)=O)CC[C@]12C.O>>C=C1[C@@H](OC(C)=O)C[C@H]2[C@H](CN)[C@@H]([C@@]3(C)CC[C@H](OC(C)=O)C[C@@H]3COC(C)=O)CC[C@]12C.[NH4+].[OH-],,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20080004309A1,CCOC(=O)c1sc(N(C(=O)OC(C)(C)C)c2ccccc2)nc1C.O=C1CCC(=O)N1Br>>CCOC(=O)c1sc(N(C(=O)OC(C)(C)C)c2ccccc2)nc1CBr,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20080176830A1,O=C1CCc2cc(Br)cc([N+](=O)[O-])c2N1.OB(O)c1ccc(C(F)(F)F)cc1>>O=C1CCc2cc(-c3ccc(C(F)(F)F)cc3)cc([N+](=O)[O-])c2N1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,[Cs+].[F-],,val
US05663271,CC[Si]1(CC)[Si](CC)(CC)[Si](CC)(CC)[Si]1(CC)CC.C[Si](C)(C)Cl.[Li][Si](C)(C)c1ccccc1>>CC[Si](CC)([Si](C)(C)C)[Si](CC)(CC)[Si](CC)(CC)[Si](CC)(CC)[Si](C)(C)c1ccccc1,,C1CCOC1,CCCCCC,O=C([O-])O.[Na+],,val
US20030229120A1,BrBr.O=C(O)CCCCOc1ccc(C=C2SC(=O)NC2=O)c2ccccc12>>O=C(O)CCCCOc1c(Br)cc(C=C2SC(=O)NC2=O)c2ccccc12,,CC(=O)O,,,,val
US20160136172A1,ClCI.O=C(NCc1ccc(F)cc1)c1nc(Br)ccc1O>>O=C1c2nc(Br)ccc2OCN1Cc1ccc(F)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130261101A1,CC(=O)c1cc(Cl)c(C#N)c(I)c1O.CC(C)(C)OC(=O)NCCO>>CC(=O)c1cc(Cl)c(C#N)c(I)c1OCCNC(=O)OC(C)(C)C,,C1CCOC1,CCOC(C)=O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160145252A1,COC(=O)c1nnc(-c2cnc(-c3cccc(-c4cnn(C)c4)c3)nc2NC2CCCN(C(=O)OC(C)(C)C)C2)s1.Cl>>COC(=O)c1nnc(-c2cnc(-c3cccc(-c4cnn(C)c4)c3)nc2NC2CCCNC2)s1.Cl,,C1COCCO1,,,,val
US06387928B1,CCOC(=O)C(=CNC1CC1)C(=O)c1cc([N+](=O)[O-])c(F)c(Cl)c1F>>CCOC(=O)c1cn(C2CC2)c2c(Cl)c(F)c([N+](=O)[O-])cc2c1=O,,CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100167934A1,Cc1ccc2c(c1)[C@H](N)[C@@H](C)C2.Nc1nc(Cl)ncc1Br>>Cc1ccc2c(c1)[C@H](Nc1ncc(Br)c(N)n1)[C@@H](C)C2,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20130065905A1,CCCS(=O)(=O)Nc1nc2ccccc2nc1Cl.C[Si](C)(C)CCOCCl>>CCCS(=O)(=O)N(COCC[Si](C)(C)C)c1nc2ccccc2nc1Cl,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20120015942A1,COC(=O)C1CCc2ccc(N)cc2C1.O=S(=O)(Cl)c1ccccc1>>COC(=O)C1CCc2ccc(NS(=O)(=O)c3ccccc3)cc2C1,,ClCCl,,Cl,c1ccncc1,val
US20030236286A1,NCCCCc1ccccc1.O=C1CCC(c2ccc(O)cc2)CC1>>Oc1ccc([C@@H]2CC[C@H](NCCCCc3ccccc3)CC2)cc1,,CC(=O)O,ClCCCl,[Na+].[OH-],,val
US20110097287A1,CCCCCCCCCCCCCCCCCCCCCC(=O)OCCOCCO.Cc1ccc(S(=O)(=O)Cl)cc1>>CCCCCCCCCCCCCCCCCCCCCC(=O)OCCOCCOS(=O)(=O)c1ccc(C)cc1,,ClCCl,,CCN(CC)CC,O,val
US20050176795A1,CCOC(CNC1CCC2(CC1)OCCO2)OCC.Nc1ccc(Oc2ccccc2)cc1.O=C(n1ccnc1)n1ccnc1>>O=C1CCC(n2ccn(-c3ccc(Oc4ccccc4)cc3)c2=O)CC1,,CN(C)C=O,O,O=C(O)C(F)(F)F,,val
US20090163501A1,Fc1cnc(Cl)nc1Cl.OB(O)c1cccnc1Oc1ccc(Nc2nnc(-c3ccccc3)c3ccccc23)cc1>>Fc1cnc(Cl)nc1-c1cccnc1Oc1ccc(Nc2nnc(-c3ccccc3)c3ccccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,ClCCl,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20070123535A1,CNC(=O)CC(c1c[nH]c2ncccc12)C1CCCCC1>>CNCCC(c1c[nH]c2ncccc12)C1CCCCC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050070563A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OC[C@H]1CNC[C@@H]1c1ccccc1>>CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@H](CO)C1,,C1CCOC1,,CCN(CC)CC,,val
US20050065143A1,NCC(O)C1CC1.O=C(O)c1ccc(Cl)nn1>>O=C(NCC(O)C1CC1)c1ccc(Cl)nn1,,C1COCCO1,O,CCN(CC)CC,O=S(Cl)Cl,val
US20020123488A1,COCCO.CSc1nnc(C#N)c(N2CCc3ccccc3CC2)n1>>COCCOc1nnc(C#N)c(N2CCc3ccccc3CC2)n1,,C1CCOC1,,[H-].[Na+],,val
US20110319394A1,Clc1nc2ccccc2o1.Nc1ccc(N)cc1>>Nc1ccc(Nc2nc3ccccc3o2)cc1,,CN1CCCC1=O,O,,,val
US20130261298A1,COc1cc(CC#N)c(CCNC(=O)C(F)(F)F)cc1OC>>COc1cc(CC#N)c(CCN)cc1OC,,O,,CCO,O=C([O-])[O-].[K+].[K+],val
US20110059954A1,Cc1cc(C(=O)c2cc(N3CCC(n4c(=O)[nH]c5ncccc54)CC3)ncn2)cc(C)c1OCc1ccccc1>>Cc1cc(C(=O)c2cc(N3CCC(n4c(=O)[nH]c5ncccc54)CC3)ncn2)cc(C)c1O,[Pd],CO,,[H][H],,val
US05103013,CCOC(=O)C(C(=O)OCC)=C1SCS1>>CCOC(=O)C(C(=O)O)=C1SCS1,,CCO,,[K+].[OH-],,val
US20060173199A1,CCOC(=O)[C@@H]1OCC=C[C@@H]1OC(C)=O>>OC[C@@H]1OCC=C[C@@H]1O,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150031727A1,CCC(CC)NCc1cccc(C(=O)Nc2sc3c(c2C(=O)OC(C)(C)C)CCCC3)c1>>CCC(CC)NCc1cccc(-c2nc3sc4c(c3c(=O)o2)CCCC4)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120208819A1,C#Cc1cnc(NCc2ccc(-c3ccc4ncnc(N)c4c3)s2)c(C(=O)NCc2ccc(F)c(F)c2)c1>>CCc1cnc(NCc2ccc(-c3ccc4ncnc(N)c4c3)s2)c(C(=O)NCc2ccc(F)c(F)c2)c1,[Pd],,,,,val
US20130131018A1,CCCOc1c(OC)cc(Cc2cncc3c(N=C(c4ccccc4)c4ccccc4)c(OCC)ccc23)cc1OC.O=C1c2ccccc2C(=O)N1O.[O-][Cl+][O-]>>CCCOc1c(OC)cc(C(=O)c2cncc3c(N)c(OCC)ccc23)cc1OC.Cl,,CC#N,CCOCC,O,,val
US20060046999A1,C#CC(=O)OC.COc1ccc(NC(=N)CC(=O)c2ccc(OC)cc2)cc1>>COc1ccc(C(=O)c2ccc(=O)n(-c3ccc(OC)cc3)c2N)cc1,,CO,,CCOCC,,val
US20120184747A1,CCCCN(CC(F)(F)F)c1ccc(CC(NS(=O)(=O)c2ccccn2)c2cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)cc1>>CCCCN(CC(F)(F)F)c1ccc(CC(NS(=O)(=O)c2ccccn2)c2cccc(NCC(=O)O)n2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070072879A1,N#Cc1ccnc(N)c1.NO>>N=C(NO)c1ccnc(N)c1,,CCO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US07531553B2,O=[N+]([O-])c1ccc(Cl)c(O)c1.OCC1CCCO1>>O=[N+]([O-])c1ccc(Cl)c(OCC2CCCO2)c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US07230114B2,CC(=O)N[C@@H]1[C@@H](N/C(=N\C(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)C=C(C(=O)OC(c2ccccc2)c2ccccc2)O[C@H]1[C@H](O)[C@H](O)CO.O=C(n1ccnc1)n1ccnc1>>CC(=O)N[C@@H]1[C@@H](NC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)C=C(C(=O)OC(c2ccccc2)c2ccccc2)O[C@H]1[C@H](O)[C@H]1COC(=O)O1,,CC#N,,,,val
US20150038438A1,COc1ccc(Cn2c3c(cc(C(=O)O)c2=O)CCCc2cc4c(cc2-3)cc(CO)n4C)c(OC)c1>>COc1ccc(Cn2c3c(cc(C(=O)O)c2=O)CCCc2cc4c(cc2-3)cc(C=O)n4C)c(OC)c1,O=[Mn]=O,ClCCl,,,,val
US20130338134A1,C1COCCN1.CCN1C(=O)N(c2c(F)c(OC)cc(OC)c2F)Cc2cnc3c(cc(C=O)n3S(=O)(=O)c3ccccc3)c21>>CCN1C(=O)N(c2c(F)c(OC)cc(OC)c2F)Cc2cnc3c(cc(CN4CCOCC4)n3S(=O)(=O)c3ccccc3)c21,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20020173663A1,CCCc1ccc(O)c(CCC)c1O.Cc1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCCc1ccc(O)c(CCC)c1O.O=C(c1ccccc1)C(F)(F)F,,Cc1ccccc1,,O=S(=O)(O)C(F)(F)F,,val
US20160002169A1,CC(C)(C)OC(=O)C[C@@H]1C[C@@H](C(=O)O)C1.COc1ccc2c(c1)CCN[C@H]2C(=O)Nc1cc(F)c([Si](C)(C)C)c(F)c1>>COc1ccc2c(c1)CCN(C(=O)[C@@H]1C[C@@H](CC(=O)OC(C)(C)C)C1)[C@H]2C(=O)Nc1cc(F)c([Si](C)(C)C)c(F)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04033972,CSc1ccc(N(C)C(=O)Cl)cc1.OCc1cccnc1>>CSc1ccc(N(C)C(=O)OCc2cccnc2)cc1,,c1ccccc1,,CCN(CC)CC,,val
US20130190316A1,COc1cc(C=O)c(OCc2c(Cl)ncc3ccccc23)cn1.C[Si](C)(C)CCOCn1nccc1B(O)O>>COc1cc(C=O)c(OCc2c(-c3ccnn3COCC[Si](C)(C)C)ncc3ccccc23)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030022898A1,COC(=O)c1cc2ccccc2cc1-c1cncn1C>>Cn1cncc1-c1cc2ccccc2cc1C(=O)O,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20100227872A1,CCOc1ccc(OC(F)(F)F)c(B(O)O)c1.Cc1nocc1C(=O)Nc1cnc(Cl)c(N)n1>>CCOc1ccc(OC(F)(F)F)c(-c2ncc(NC(=O)c3conc3C)nc2N)c1,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05618949,CC/C=C/C(=O)N1C(=O)OC[C@@H]1c1ccccc1.COCN(Cc1ccccc1)C[Si](C)(C)C>>CC[C@@H]1CN(Cc2ccccc2)C[C@H]1C(=O)N1C(=O)OC[C@@H]1c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150111914A1,COC(=O)c1ccc2c(c1)C(F)(F)C1(C2)C(=O)Nc2ncccc21>>O=C(O)c1ccc2c(c1)C(F)(F)C1(C2)C(=O)Nc2ncccc21,,CO,,Cl,[Na+].[OH-],val
US20020019527A1,CC(C)(C)OC(=O)NC1CCNCC1.Cn1cncc1C(O)c1ccc(C#N)c(-c2cccc3ccccc23)c1>>Cn1cncc1C(c1ccc(C#N)c(-c2cccc3ccccc23)c1)N1CCC(NC(=O)OC(C)(C)C)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20100173901A1,CC1(C)OB(c2cnn(CC3CCC3)c2)OC1(C)C.CC1Cc2ccc(Br)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1>>CC1Cc2ccc(-c3cnn(CC4CCC4)c3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,O,C1COCCO1,O=C([O-])O.[Na+],val
US06045720,BrP(Br)Br.CCCCC(O)OCC>>CCOCCCCCBr,,c1ccccc1,,O,c1ccncc1,val
US20050032846A1,CCC(O)CC.Cc1cc(C)c(C(C)(C#N)c2nc(C)nc(Cl)c2C)c(C)c1>>CCC(CC)Oc1nc(C)nc(C(C)(C#N)c2c(C)cc(C)cc2C)c1C,,C1CCOC1,,[H-].[Na+],,val
US20020188000A1,N#Cc1ccccc1-c1cccc(N)c1.O=S(=O)(O)O>>N#Cc1ccccc1-c1cccc(O)c1,,C1COCCO1,O,O=N[O-].[Na+],,val
US20060183769A1,CC(=O)OC(C)=O.Nc1ccc(-c2nc3c(C(=O)NC4CN5CCC4CC5)cccc3o2)cc1>>CC(=O)Nc1ccc(-c2nc3c(C(=O)NC4CN5CCC4CC5)cccc3o2)cc1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,c1ccncc1,,val
US20120316161A1,CCCC(C(=O)OCC)c1c(C)nc2c(Br)cnn2c1Cl.Cc1ccc([Mg]Br)cc1>>CCCC(C(=O)OCC)c1c(C)nc2c(Br)cnn2c1-c1ccc(C)cc1,,C1CCOC1,,O,[Cl-].[NH4+],val
US04271164,CN=C=S.Cc1ncc2cc(-c3c(Cl)cccc3Cl)c(N)nc2n1>>CNC(=S)Nc1nc2nc(C)ncc2cc1-c1c(Cl)cccc1Cl,,Cc1ccccc1,,,,val
US20110263571A1,Cc1cnc(N2CCN(C(=O)c3ccc(N4CCOC4=O)cc3N)CC2)c(C)c1.O=S(=O)(Cl)CCCCl>>Cc1cnc(N2CCN(C(=O)c3ccc(N4CCOC4=O)cc3N3CCCS3(=O)=O)CC2)c(C)c1,,O,,C1CCOC1,CCN(CC)CC,val
US20130225808A1,Cc1cc(O)cc(C)c1Br.Cc1ccc(S(=O)(=O)OC[C@@H]2CN(C)c3ccccc3O2)cc1>>Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)cc(C)c1Br,,CC(=O)N(C)C,,O,O=C([O-])[O-].[K+].[K+],val
US20150225412A1,COC(=O)c1ccc2c(c1)nc(NC(=O)c1ccc(C(F)F)s1)n2C[C@H]1CCCN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCC[C@@H]1Cn1c(NC(=O)c2ccc(C(F)F)s2)nc2cc(C(=O)O)ccc21,,C1CCOC1,,[K+].[OH-],,val
US05162328,O=C(O)CCC(=O)O.c1cc(Nc2nccc(-c3cccs3)n2)cc(OCCn2ccnc2)c1>>O=C(O)CCC(=O)O.c1cc(Nc2nccc(-c3cccs3)n2)cc(OCCn2ccnc2)c1,,CCO,,,,val
US20070135631A1,NC(Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(F)c(C(F)(F)F)c1.O=C=NC1CCCC1>>O=C(NC1CCCC1)NC(Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(F)c(C(F)(F)F)c1,,C1COCCO1,,,,val
US20130210809A1,COc1ccc(Cn2cc(C(=O)O)c(Br)n2)cc1.O=C(Cl)C(=O)Cl>>COc1ccc(Cn2cc(C(=O)Cl)c(Br)n2)cc1,CN(C)C=O,ClCCl,,,,val
US20140171420A1,Cc1[nH]nc(C(F)(F)F)c1Cl.O=C1OCCCCC1Br>>Cc1c(Cl)c(C(F)(F)F)nn1C1CCCCOC1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05284863,Cn1cc(-c2ccc(Cl)cc2)c(S(=O)(=O)C(F)(F)F)c1.O=C=NS(=O)(=O)Cl>>Cn1cc(S(=O)(=O)C(F)(F)F)c(-c2ccc(Cl)cc2)c1Cl,,COCCOC,O,CN(C)C=O,,val
US05698495,Cc1ccc([N+](=O)[O-])c(F)c1.Cn1nc(C(F)(F)F)cc1O>>Cc1ccc([N+](=O)[O-])c(Oc2cc(C(F)(F)F)nn2C)c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050203128A1,CC1(CC=O)CCOc2ccccc21>>CC1(CCO)CCOc2ccccc21,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070032517A1,CC(=O)OCC(=O)Cl.CC(=O)c1c(N)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2n(C)c1=O>>CC(=O)OCC(=O)Nc1c(C(C)=O)c(=O)n(C)c2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc12,,CC#N,CCOC(C)=O,,,val
US20130267703A1,Nc1cc(OCCN2CCCCC2)ccc1Cl.O=C(Cl)C=Cc1ccccc1>>O=C(C=Cc1ccccc1)Nc1cc(OCCN2CCCCC2)ccc1Cl,,O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20120295863A1,NCc1ccc([N+](=O)[O-])cc1.OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O>>O=[N+]([O-])c1ccc(CNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1,,CCCO,,CCN(C(C)C)C(C)C,Cl,val
US20090088439A1,BrCCn1cccc1.O=c1[nH]c2nc3c(nc2c(=O)n1Cc1ccc(Cl)cc1)CCCC3>>O=c1c2nc3c(nc2n(CCn2cccc2)c(=O)n1Cc1ccc(Cl)cc1)CCCC3,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20040072850A1,CC(C)(C)OC(=O)CC(NC(=O)OCc1ccccc1)C(=O)COc1c(F)c(F)cc(F)c1F>>CC(C)(C)OC(=O)C[C@H](NC(=O)OCc1ccccc1)C(O)COc1c(F)c(F)cc(F)c1F,,C1CCOC1,,[BH4-].[Na+],,val
US20090239810A1,CN(c1ccccc1Br)C1CCN(C(=O)OC(C)(C)C)CC1>>CN(c1ccccc1Br)C1CCNCC1,,C1COCCO1,,Cl,,val
US20090047238A1,CC(C)(C)CC(=O)N1C[C@H](C=O)[C@@H](c2ccccc2)C1.ClCCCl>>Cl.c1ccc(C2CCNC2)cc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040176395A1,COC(=O)c1ccc(/C=N/CC(=O)OC(C)(C)C)cc1>>COC(=O)c1ccc(CNCC(=O)OC(C)(C)C)cc1,,CO,,[BH4-].[Na+],,val
US20150119387A1,NN.O=c1[nH]ccc2cc(Cl)nc(Cl)c12>>NNc1nc(Cl)cc2cc[nH]c(=O)c12,,CC(C)O,,,,val
US20090042852A1,CC(C)(C)OC(=O)CCC1CNCCN1.CCOC(=O)c1cnc(Cl)c(Cl)c1>>CCOC(=O)c1cnc(N2CCNC(CCC(=O)OC(C)(C)C)C2)c(Cl)c1,,CCO,CCOC(C)=O,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20110281865A1,CC(=O)c1ccc2nnn(Cc3ccc4ncccc4c3)c2n1.CON>>CON=C(C)c1ccc2nnn(Cc3ccc4ncccc4c3)c2n1,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20140275548A1,CCOC(=O)c1cnc2cc(O)cnc2c1.CCOC(=O)c1cnc2cc(OCc3ccc(F)cc3)cnc2c1.Fc1ccc(CCl)cc1>>CC(C)(O)c1cnc2cc(OCc3ccc(F)cc3)cnc2c1,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20140350010A1,Cc1cc([N+](=O)[O-])c(=O)n(C)c1>>Cc1cc(N)c(=O)n(C)c1,[Ni],CO,,,,val
US05739345,Cn1c(COc2ccc(CC3SC(=O)N(C(c4ccccc4)(c4ccccc4)c4ccccc4)C3=O)cc2)cc2ccccc21>>Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)cc2ccccc21,[Pd],C1COCCO1,,,,val
US05041455,CI.c1ccc(COc2nsnc2-c2cccnc2)cc1>>C[n+]1cccc(-c2nsnc2OCc2ccccc2)c1.[I-],,CC(C)=O,,,,val
US20030109527A1,O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)NCCCN2CCOCC2)c1O>>Nc1ccc(Cl)c(S(=O)(=O)NCCCN2CCOCC2)c1O,[Pd],,,[H][H],,val
US20110021537A1,CC(C)(C)OC(=O)CC[C@H](NC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NCC2CC2)n(-c2ccccc2)n1)C(=O)O.CCOC(=O)N1CCNC[C@H]1C>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)O)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NCC3CC3)n(-c3ccccc3)n2)C[C@H]1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040010007A1,Cc1cc(Cl)c([N+](=O)[O-])c(Cl)n1.NCCOCCCc1cccnc1>>Cc1cc(NCCOCCCc2cccnc2)c([N+](=O)[O-])c(Cl)n1,,CN(C)C=O,,CCN(CC)CC,,val
US20090042900A1,COC(=O)C1CCC(Cc2ccccc2F)CC1>>OCC1CCC(Cc2ccccc2F)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090192138A1,CC#CCn1c(N2CCCN(C(=O)OC(C)(C)C)CC2)c(C#N)c2nc[nH]c(=O)c21.Cc1nc(CCl)nc2ccccc12>>CC#CCn1c(N2CCCNCC2)c(C#N)c2ncn(Cc3nc(C)c4ccccc4n3)c(=O)c21,,CN(C)C=O,ClCCl,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20160214097A1,FC(F)(F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.II>>FC(F)(F)c1cc(C(F)(F)F)c(I)c(C(F)(F)F)c1,,CCOCC,,CC(C)NC(C)C,[Li]CCCC,val
US20120252758A1,COc1ccc(Cl)cc1C(C)(C)C(F)(F)F>>CC(C)(c1cc(Cl)ccc1O)C(F)(F)F,,ClCCl,,BrB(Br)Br,,val
US20080132505A1,CC(O)CNC(=O)c1cnc(Nc2cccc(Cl)c2)nc1C(F)(F)F>>CC(=O)CNC(=O)c1cnc(Nc2cccc(Cl)c2)nc1C(F)(F)F,,CS(C)=O,ClCCl,CCN(CC)CC,,val
US20100311730A1,CC(C)(C)OC(=O)N1CCC(COc2cc(Nc3cnc(C#N)cn3)ncc2N)CC1>>N#Cc1cnc(Nc2cc(OCC3CCNCC3)c(N)cn2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120258949A1,COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCN(CCc3ccccc3)C1)O2>>O=C(O)/C=C/c1ccc2c(c1)C(=O)CC1(CCN(CCc3ccccc3)C1)O2,,CC(=O)O,,Cl,,val
US20140336106A1,O=C(CBr)OCc1ccccc1.OC1CCNCC1>>O=C(CN1CCC(O)CC1)OCc1ccccc1,,ClCCl,,CCN(CC)CC,O,val
US20120202834A1,Brc1ccc(Br)nc1.CCCC=O>>CCCC(O)c1ccc(Br)cn1,,Cc1ccccc1,,[Li]CCCC,,val
US20050070556A1,CC(=O)OC[C@H]1O[C@@H](n2c(=O)sc3cnc(N)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O.CC(C)(C)[Si](C)(C)Cl>>CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2c(=O)sc3cnc(N)nc32)[C@H](O)[C@@H]1O,,CN(C)C=O,,c1c[nH]cn1,,val
US20150376194A1,NS(=O)(=O)c1ccc(S(=O)(=O)Cl)cc1.O=C(OCc1cc(Cl)cc(Cl)c1)N1C[C@@H]2CNC[C@@H]2C1>>NS(=O)(=O)c1ccc(S(=O)(=O)N2C[C@@H]3CN(C(=O)OCc4cc(Cl)cc(Cl)c4)C[C@@H]3C2)cc1,,C1CCOC1,,Cl,c1ccncc1,val
US20130041007A1,Nc1cccc(Cl)c1Cl.O=C(O)C1CCCCC1=O.O=N[O-]>>O=C1CCCCC1=NNc1cccc(Cl)c1Cl,,O,,Cl,,val
US05292726,Cc1cccc(N(C(=O)Cl)c2ccccc2)c1.O=C(O)[C@@H]1CN(C(=O)OCc2ccccc2)CCN1>>Cc1cccc(N(C(=O)N2CCN(C(=O)OCc3ccccc3)C[C@H]2C(=O)O)c2ccccc2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US06699995B1,COC(=O)CCc1oc(Cl)nc1-c1ccc(Cl)cc1.Cc1ncc[nH]1>>COC(=O)CCc1oc(-n2ccnc2C)nc1-c1ccc(Cl)cc1,,O,,CS(C)=O,,val
US20150182507A1,O=C1c2ccccc2C(=O)N1Cc1nc2ccccn2c1C#Cc1cccc(C(F)(F)F)c1>>NCc1nc2ccccn2c1C#Cc1cccc(C(F)(F)F)c1,,CCO,,NN,O,val
US20100183603A1,N#CCC(=O)c1cn2c3c(cccc13)CCC2>>N#C/C=C/c1cn2c3c(cccc13)CCC2,,CN(C)C=O,,[BH4-].[Na+],,val
US20090105252A1,Cc1ncc(-c2nc(Nc3ccc(C(=O)c4ccccn4)cc3)ncc2F)n1C>>Cc1ncc(-c2nc(Nc3ccc(C(O)c4ccccn4)cc3)ncc2F)n1C,,CCO,,Cl,[BH4-].[Na+],val
US20090005558A1,CC(C)(C)OC(=O)NCCBr.N#Cc1ccc(OCCN2CC3CNCC(C2)O3)c(F)c1>>CC(C)(C)OC(=O)NCCN1CC2CN(CCOc3ccc(C#N)cc3F)CC(C1)O2,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20160264594A1,CO[Si](O[C@H]1[C@@H](CC2COC(C)(C)O2)O[C@@H]2[C@H]1O[C@H]1CC[C@H](CCOC(=O)C(C)(C)C)O[C@@H]1[C@@H]2O)(C(C)C)C(C)C>>CC1(C)OCC(C[C@H]2O[C@@H]3[C@@H](O[C@H]4CC[C@H](CCOC(=O)C(C)(C)C)O[C@@H]4[C@@H]3O)[C@H]2O)O1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100173933A1,Cc1ccccc1S(=O)(=O)Cl.NC(=O)c1cccc(OCCCCCCCCCO)c1>>Cc1ccc(S(=O)(=O)OCCCCCCCCCOc2cccc(C(N)=O)c2)cc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US05650428,CCOC(=O)Cc1ccc(NC(=O)C(COC2CCCCO2)NC(=O)OCc2ccccc2)cc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>CCOC(=O)Cc1ccc(NC(=O)C(COC2CCCCO2)NS(=O)(=O)c2ccc(Cl)cc2)cc1,[Pd],,,,,val
US20100137353A1,C=CC=O.Fc1cncc(Br)c1>>O=C/C=C/c1cncc(F)c1,,ClCCl,,O,CC(=O)[O-].[Na+],val
US05422358,BrCCc1ccccc1.N#CC(c1ccccc1)(c1ccccc1)[C@H]1CCCNC1>>N#CC(c1ccccc1)(c1ccccc1)[C@H]1CCCN(CCc2ccccc2)C1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150376129A1,O=C(O)c1cc(Br)ccc1Cl.[Cl-]>>O=C(Cl)c1cc(Br)ccc1Cl,CN(C)C=O,ClCCl,,,,val
US20020151717A1,CS(=O)(=O)Cl.OCCc1ccc(F)cc1>>CS(=O)(=O)OCCc1ccc(F)cc1,,Cl,O,CCN(CC)CC,ClCCl,val
US20040254215A1,CCOC(=O)CN1C(=O)c2ccc([N+](=O)[O-])cc2C1=O>>CCOC(=O)CN1C(=O)c2ccc(N)cc2C1=O,[Pd],CC(=O)O,,,,val
US20160272617A1,CC(C)(C)OC(=O)N1CCC(N)C(C)(C)C1.Cc1cc(C(=O)O)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nc(C(F)(F)C(F)(F)C(=O)O)n[nH]3)cc2)cc1>>Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2(C)C)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nnc(C(F)(F)C(F)(F)C(=O)O)[nH]3)cc2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130131040A1,N#Cc1ncc(N[C@@H]2CCCC(F)(F)[C@@H]2N)nc1Nc1ccccc1.OO>>NC(=O)c1ncc(N[C@@H]2CCCC(F)(F)[C@@H]2N)nc1Nc1ccccc1,,CCO,CS(C)=O,CC(=O)O,[Na+].[OH-],val
US20020137755A1,O=C1NCCN1CCO.O=S(Cl)Cl>>O=C1NCCN1CCCl,,ClC(Cl)Cl,,,,val
US20150210720A1,CCOc1nc(N2CCN(C(C)=O)CC2)ccc1N.Cn1cc2cc(N)ccc2n1.O=C(O)c1coc2c1C(=O)CC1(CC1)C2>>CCOc1nc(N2CCN(C(C)=O)CC2)ccc1NC(=O)c1coc2c1C(=O)N(C)C(C)(C)C2,,CCCCCC,CCOC(C)=O,CCO,,val
US05891889,Cc1cccc([C@@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2O)c1.Cl>>Cc1cccc([C@@H]2CCNC[C@H]2O)c1.Cl,,CCOC(C)=O,,,,val
US04460596,CC(C)O.O=C(O)Cc1nc(-c2ccc(F)cc2)oc1-c1ccsc1>>CC(C)OC(=O)Cc1nc(-c2ccc(F)cc2)oc1-c1ccsc1,,C1CCOC1,O,CCN(CC)CC,C[n+]1ccccc1Cl.[I-],val
US20090247538A1,CCOC(=O)c1cnc2[nH]ncc2c1N1CCC(N)(Cc2ccc(C(C)(C)C)cc2)CC1>>CC(C)(C)c1ccc(CC2(N)CCN(c3ccnc4[nH]ncc34)CC2)cc1,,[K+],[OH-],O,,val
US04039543,COC(=O)c1cc([N+](=O)[O-])c(C(C)(C)C)c([N+](=O)[O-])c1>>COC(=O)c1cc(N)c(C(C)(C)C)c(N)c1,[Pd],CO,,,,val
US20150353553A1,Cn1c(=O)[nH]c(=O)c2[nH]c(CO)nc21.FC(F)(F)c1ccc(CBr)cc1>>Cn1c(=O)[nH]c(=O)c2c1nc(CO)n2Cc1ccc(C(F)(F)F)cc1,,CS(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US05021574,Cc1nc2nc[nH]c2c(=O)[nH]1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>Cc1nc(S)c2[nH]cnc2n1,,c1ccncc1,,,,val
US20110020460A1,CCOC(OCC)OCC.Nc1ccc(OCc2ccccc2)c(F)c1.[N-]=[N+]=[N-]>>Fc1cc(-n2cnnn2)ccc1OCc1ccccc1,,O,,CC(=O)O,,val
US20090281092A1,CC1(F)CN(C2CCCCC2)c2nc(Cl)ncc2NC1=O.CI>>CN1C(=O)C(C)(F)CN(C2CCCCC2)c2nc(Cl)ncc21,,CC(=O)N(C)C,,[H-].[Na+],,val
US20130059834A1,CC(C)(C)OC(=O)n1cc(B2OC(C)(C)C(C)(C)O2)c2ccc(Cl)cc21.C[C@@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Br)nc12)C(=O)N1CC(C#N)C1>>C[C@@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3c[nH]c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20060287324A1,CCNC1(C(N)=O)CCNC1.Clc1ccc(-c2cc3nnc(Cl)n3nc2-c2ccccc2Cl)cc1>>CCNC1(C(N)=O)CCN(c2nnc3cc(-c4ccc(Cl)cc4)c(-c4ccccc4Cl)nn23)C1,,OCCO,,,,val
US04652563,NCc1ccccc1.c1cc(OCC2CO2)ccc1CCOCC1CC1>>OC(CNCc1ccccc1)COc1ccc(CCOCC2CC2)cc1,,CCCO,,,,val
US20080188528A1,CC(C)(C)OC(=O)NCCC[C@H](NC(=O)c1ccc(C(c2cccs2)c2cccs2)s1)C(=O)O.O=C(O)C(F)(F)F>>NCCC[C@H](NC(=O)c1ccc(C(c2cccs2)c2cccs2)s1)C(=O)O.O=C(O)C(F)(F)F,,O,,CC[SiH](CC)CC,,val
US06242601B1,CCOC(=N)c1cccc(OCc2ccccc2)c1.F[B-](F)(F)F.N>>F[B-](F)(F)F.N=C(N)c1cccc(OCc2ccccc2)c1,,CCO,,,,val
US05859256,O=S(Cl)Cl.OCc1cnccc1Cl>>Cl.ClCc1cnccc1Cl,,CN(C)C=O,,,,val
US20150376181A1,CCOC(=O)c1[nH]c(=O)c(Br)cc1Cl.COc1ccc(CCl)cc1>>CCOC(=O)c1c(Cl)cc(Br)c(=O)n1Cc1ccc(OC)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090181928A1,CC(Cc1ccc(N2CC(=O)NS2(=O)=O)c(OCc2ccccc2)c1)C(=O)c1ccccc1>>CC(Cc1ccc(N2CC(=O)NS2(=O)=O)c(O)c1)C(O)c1ccccc1,[Pd],CCO,O,[K],,val
US20130310379A1,COC(=O)c1ccc(COc2cccc(C)c2)cc1>>Cc1cccc(OCc2ccc(C(=O)O)cc2)c1,,CCO,O,Cl,[Na+].[OH-],val
US20060135551A1,CCC1CC(=O)c2cc(C)nc(C)c2N1.CCOC(=O)Cl>>CCOC(=O)N1c2c(cc(C)nc2C)C(=O)CC1CC,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20040225111A1,CC(C)(C)OC(=O)[C@H](Cc1ccc(OCCCC(=O)NC2=NCCCN2)cc1)Nc1nc2ccccc2o1>>O=C(CCCOc1ccc(C[C@H](Nc2nc3ccccc3o2)C(=O)O)cc1)NC1=NCCCN1,,ClCCl,,Cc1ccccc1,O=C(O)C(F)(F)F,val
US20090325903A1,CC(C)(O)CC(=O)O.CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B1OB([C@H](CC(C)C)NC(=O)CNC(=O)c2cc(Cl)ccc2Cl)OB([C@H](CC(C)C)NC(=O)CNC(=O)c2cc(Cl)ccc2Cl)O1>>CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B1OC(=O)CC(C)(C)O1,,CCOC(C)=O,,,,val
US05981533,CSC(SC)=C(C#N)C#N.NCc1ccc(N)cc1>>CSC(NCc1ccc(N)cc1)=C(C#N)C#N,,CCO,,,,val
US04148998,CC(=O)O.COC1CCC(OC)O1.NC(C(=O)O)S(=O)(=O)O>>O=C(O)C(n1cccc1)S(=O)(=O)O,,CC(=O)O,CCOC(C)=O,Cl,CC(=O)[O-].[Na+],val
US05280032,CC(=O)OC(COCCN(C)C)c1ccc2c(c1)CC=C2.Cl>>CN(C)CCOCC(O)c1ccc2c(c1)CC=C2.Cl,,CCO,CO,C[O-].[Na+],,val
US20130096113A1,COc1cc2ncn(Cc3ccc4nc(SC)oc4c3)c2cc1OC.O=C(OO)c1cccc(Cl)c1>>COc1cc2ncn(Cc3ccc4nc(S(C)=O)oc4c3)c2cc1OC,,ClCCl,,O=C([O-])O.[Na+],,val
US20090281098A1,CCOC(=O)c1c(C)[nH]c(-c2nc3ccc(C(=O)c4ccccc4)cc3[nH]2)c1C>>Cc1[nH]c(-c2nc3ccc(C(=O)c4ccccc4)cc3[nH]2)c(C)c1C(=O)O,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US06177449B1,CC1(C)CC(NS(C)(=O)=O)c2cc(OCc3ccccc3)ccc2O1.COCCBr>>COCCN(C1CC(C)(C)Oc2ccc(OCc3ccccc3)cc21)S(C)(=O)=O,,CC(=O)N(C)C,,[H-].[Na+],,val
US20050043537A1,COc1cc(N)c(Cl)cc1Cl.N#CCC(=O)O>>COc1cc(NC(=O)CC#N)c(Cl)cc1Cl,,C1CCOC1,,CC(C)N=C=NC(C)C,,val
US20040106595A1,CC(C)(C)C(=O)Cl.COc1ccc(-c2coc3cc(O)ccc3c2=O)cc1>>COc1ccc(-c2coc3cc(OC(=O)C(C)(C)C)ccc3c2=O)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110034464A1,BrBr.CS(=O)(=O)c1ccc(Cl)cc1CO>>CS(=O)(=O)c1ccc(Cl)cc1CBr,,CC#N,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130109661A1,CCC1CCCN1.Nc1cccc(F)n1>>CCC1CCCN1c1cccc(N)n1,,O,,,,val
US04141901,CCNCC.O=C(NCc1nnc(CCl)n1-c1ccc(Cl)cc1C(=O)c1ccccc1Cl)OCc1ccccc1>>CCN(CC)Cc1nnc(CNC(=O)OCc2ccccc2)n1-c1ccc(Cl)cc1C(=O)c1ccccc1Cl,,CO,ClC(Cl)Cl,[I-].[K+],,val
US20060135508A1,CCOC(=O)n1nc(I)c2c1CN(C(=O)OC(C)(C)C)C2>>CC(C)(C)OC(=O)N1Cc2n[nH]c(I)c2C1,,CCN(CC)CC,,CO,,val
US05013863,CC(C)OP(=O)(CCC#N)C(C)(C)C>>CC(C)OP(=O)(CCCN)C(C)(C)C,[Ni],CCO,,N,,val
US20160264518A1,COC(=O)/C=C/c1ccccc1NCc1ccccc1.NO>>O=C(/C=C/c1ccccc1NCc1ccccc1)NO,,C1CCOC1,CO,[Na+].[OH-],,val
US06271225B1,Cc1cc(C(=O)Nc2ccccc2O)c(Br)s1>>Cc1cc2c(s1)Oc1ccccc1NC2=O,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US05194430,CCOC(=O)[C@H]1[C@@H](C(=O)CP(=O)(OCC)OCC)CCCN1c1cccc2c1C(c1ccccc1)c1ccccc1-2>>CCOP(=O)(CC(=O)[C@H]1CCCN[C@H]1C(=O)OC)OCC,,CC#N,O,O=C(O)C(F)(F)F,,val
US20090036420A1,CC(C)(C)OC(=O)N1CCN(c2ncc(C(=O)Nc3cccc(Cl)c3)cc2Cl)CC1>>O=C(Nc1cccc(Cl)c1)c1cnc(N2CCNCC2)c(Cl)c1,,CCO,,[Na+].[OH-],,val
US20150239827A1,COC=C[C@@H]1Cc2ccccc2C2(C1)OCCO2>>O=CC[C@H]1CC(=O)c2ccccc2C1,,C1CCOC1,,Cl,,val
US20110166173A1,CCO.N#Cc1cnc2[nH]ccc2c1.O=S(=O)(O)O>>CCOC(=O)c1cnc2[nH]ccc2c1,,CCO,,CCOC(C)=O,O=C([O-])O.[Na+],val
US04322429,CN(C)C=C(C#N)c1ccc(C(F)(F)F)cc1.NO>>Nc1oncc1-c1ccc(C(F)(F)F)cc1,,CCO,,Cl,,val
US20100261728A1,NCCc1ccccc1.O=C(Cl)c1ccc(F)c(F)c1>>O=C(NCCc1ccccc1)c1ccc(F)c(F)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140243302A1,COC(=O)COc1ccc(Br)nc1.O=C(OO)c1cccc(Cl)c1>>COC(=O)COc1ccc(Br)[n+]([O-])c1,,ClCCl,,,,val
US20120022045A1,CC(C)(C)OC(=O)NC1(C#N)CCC(CO[Si](C)(C)C(C)(C)C)CC1.NO>>CC(C)(C)OC(=O)NC1(C(N)=NO)CCC(CO[Si](C)(C)C(C)(C)C)CC1,,CO,,,,val
US03978229,C1=COCCC1.CCOC(=O)CCCCCO>>CCOC(=O)CCCCCOC1CCCCO1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04259338,CN.Cc1oc2cc(C3CC(=O)OC(=O)C3)ccc2c1C>>Cc1oc2cc(C3CC(=O)N(C)C(=O)C3)ccc2c1C,,CC(=O)O,Cc1ccccc1,O,,val
US20070185324A1,Cc1ccc2c(=O)[nH]ncc2c1[N+](=O)[O-]>>Cc1ccc2c(=O)[nH]ncc2c1N,[Pd],CCO,,,,val
US20100292188A1,C[Si](C)(C)N=C=O.c1cc(-c2nc3c(s2)CNCC3)ccc1O[C@@H]1C[C@@H](N2CCCCC2)C1>>NC(=O)N1CCc2nc(-c3ccc(O[C@@H]4C[C@@H](N5CCCCC5)C4)cc3)sc2C1,,ClCCl,,,,val
US20110009638A1,COC(=O)c1ccc(C(=O)C=C(c2cc(Cl)cc(C(F)(F)F)c2)C(F)(F)F)c2ccccc12.NO>>COC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(C(F)(F)F)c3)(C(F)(F)F)C2)c2ccccc12,,C1CCOC1,O,O=S(=O)(O)O,[Na+].[OH-],val
US20100135999A1,CC(C)(C)OC(=O)N1CCNCC1.CCCCOC(=O)Cl>>CCCCOC(=O)N1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CCN(CC)CC,,val
US20100286396A1,COc1ccc2c(c1OC)C(C)(C)N1CCc3cc4c(cc3C1=C2)OCO4>>COc1ccc2c(c1OC)C(C)(C)N1CCc3cc4c(cc3C1C2)OCO4,,CO,,[BH4-].[Na+],,val
US04667032,CC=O.O=c1ccc2nc3ccccc3sc-2c1>>CC(=O)c1c2sc3ccccc3nc-2ccc1=O,,c1ccccc1,,,,val
US04304788,CCOC(=O)C(C)OC(C)c1ccc(-c2ccc(Cl)cc2)cc1>>CC(OC(C)c1ccc(-c2ccc(Cl)cc2)cc1)C(=O)O,,CCO,O,[Na+].[OH-],,val
US20120157425A1,CCOc1ccc(N2CCC(c3ccc([C@H](C)N)cc3)CC2)cc1.N#CCC(=O)O>>CCOc1ccc(N2CCC(c3ccc([C@H](C)NC(=O)CC#N)cc3)CC2)cc1,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20160002175A1,Cc1cccc(-c2cc(NCCCN)nc(N)n2)c1C.O=C(Cl)c1cccc(Br)c1>>Cc1cccc(-c2cc(NCCCNC(=O)c3cccc(Br)c3)nc(N)n2)c1C,,C1CCOC1,CN1CCCC1=O,CCN(CC)CC,,val
US04443451,Cc1nc2n(c(=O)c1CCBr)CCS2.OC(c1ccc(F)cc1)C1CCNCC1>>Cc1nc2n(c(=O)c1CCN1CCC(C(O)c3ccc(F)cc3)CC1)CCS2,,CC(=O)CC(C)C,,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20150376130A1,CCOC(=O)c1cccnc1NCc1cccc(OC)c1>>COc1cccc(CNc2ncccc2C(=O)O)c1,,C1CCOC1,,[Na+].[OH-],,val
US20090181942A1,CCOc1cccc(C(O)c2cc(Cl)ccc2NC(=O)OC(C)(C)C)c1OCC>>CCOc1cccc(C(O)c2cc(Cl)ccc2N)c1OCC,,C1COCCO1,,Cl,O=C([O-])O.[Na+],val
US20130053376A1,Cc1ccc(Cl)cc1C[C@H](C)N=[N+]=[N-]>>Cc1ccc(Cl)cc1C[C@H](C)N,[Pd],CCOC(C)=O,,,,val
US20030134838A1,CNc1nc(Nc2ccc(Cl)c(Cl)c2)ncc1NC(=O)N(C)CCO>>CNc1nc(Nc2ccc(Cl)c(Cl)c2)ncc1N1CCN(C)C1=O,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100063106A1,CI.COC(=O)c1cc([N+](=O)[O-])[nH]n1>>COC(=O)c1cc([N+](=O)[O-])n(C)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06759509B1,CC(C)(C)OC(=O)C(CCCN1C(=O)C=CC1=O)C(=O)OC(C)(C)C>>O=C(O)C(CCCN1C(=O)C=CC1=O)C(=O)O,,O=C(O)C(F)(F)F,,,,val
US04710507,COS(=O)(=O)OC.O=c1ccc2cc(-c3cccnc3)ccc2[nH]1>>Cn1c(=O)ccc2cc(-c3cccnc3)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20050080128A1,CCO.O=C(O)Cc1c(C(=O)O)n(-c2cccc(C(=O)O)c2)c2ccccc12>>CCOC(=O)Cc1c(C(=O)O)n(-c2cccc(C(=O)O)c2)c2ccccc12,,O,,O=S(=O)(O)O,,val
US20140206650A1,CSCNc1cccc(-c2cnc(N3CCC[C@H]3C(F)(F)F)nc2)n1.Cn1c(=O)c2c(ncn2CC(=O)O)n(C)c1=O>>CSCN(C(=O)Cn1cnc2c1c(=O)n(C)c(=O)n2C)c1cccc(-c2cnc(N3CCC[C@H]3C(F)(F)F)nc2)n1,,ClCCl,c1ccncc1,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150218187A1,CCOC(=O)C1CC2(CCN(c3ccc([N+](=O)[O-])cn3)CC2)C1>>CCOC(=O)C1CC2(CCN(c3ccc(N)cn3)CC2)C1,[Pd],CCOC(C)=O,,,,val
US20050101657A1,CCc1cccnc1.O=C1CCC(=O)N1Br>>CC(Br)c1cccnc1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20020025963A1,Cc1ccc([N+](=O)[O-])cc1C#N.O=Cc1ccccc1>>NC(=O)c1cc([N+](=O)[O-])ccc1C=Cc1ccccc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20020156081A1,Brc1ccc(Oc2ccccc2)cc1.CC(C)OB(OC(C)C)OC(C)C>>OB(O)c1ccc(Oc2ccccc2)cc1,,C1CCOC1,,[Li]CCCC,,val
US04025537,CCCCCCc1cc(C(=O)OCC)c(C)o1>>CCCCCCc1cc(C(=O)O)c(C)o1,,[Na+],[OH-],,,val
US20130131036A1,ON=C1CCC[C@H]1[C@@H](O)C1(c2ccc(Cl)c(Cl)c2)CCC1>>N[C@@H]1CCC[C@H]1[C@@H](O)C1(c2ccc(Cl)c(Cl)c2)CCC1,[Ni],CO,,O,,val
US05631257,CN1CCCNCC1.Clc1nc2ccccc2o1>>CN1CCCN(c2nc3ccccc3o2)CC1,,ClCCl,,,,val
US20130143906A1,COc1ccc(COc2nc(C)n(-c3cc(-c4ccnc(C(C)(C)O)n4)ccc3C)c(=O)c2Cl)cc1>>Cc1ccc(-c2ccnc(C(C)(C)O)n2)cc1-n1c(C)nc(O)c(Cl)c1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US06350749B1,CC#CCN.O=C1CC(=O)CC(c2ccccc2Cl)C1>>Cc1ccnc2c1C(=O)CC(c1ccccc1Cl)C2,,CCN(CC)CC,,C1CCOC1,Cl,val
US20120010182A1,CN(C)/C=C/C(=O)c1cc(-c2ccccc2C(F)(F)F)ccc1O.COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(F)cc2F)c(OC)c1>>COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3ccc(-c4ccccc4C(F)(F)F)cc3C(=O)/C=C/N(C)C)cc2F)c(OC)c1,,CS(C)=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20160002241A1,COCCOc1ccc(Nc2ncc3[nH]c(=O)n(-c4cccc(NC(=O)OC(C)(C)C)c4)c3n2)cc1>>COCCOc1ccc(Nc2ncc3[nH]c(=O)n(-c4cccc(N)c4)c3n2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040209948A1,CC1CN(C(=O)OC(C)(C)C)CCC1=O.C[C@@H](N)c1ccccc1>>C[C@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1N[C@H](C)c1ccccc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04038414,CO.COCC(=O)Oc1ccc(C=CNC(C)=O)cc1>>COc1cc(C=CNC(C)=O)ccc1OCC1CO1,,CO,,C[O-].[Na+],,val
US20100204119A1,CNC(=O)CC1CCC(c2ccc(N3CCOc4ncnc(N)c4C3=O)cc2)CC1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CNC(=S)CC1CCC(c2ccc(N3CCOc4ncnc(N)c4C3=O)cc2)CC1,,C1CCOC1,,,,val
US20040186140A1,COC(=O)c1sc(C(C)(C)C)cc1N.N=C(N)C(F)(F)F>>CC(C)(C)c1cc2nc(C(F)(F)F)nc(O)c2s1,,ClC(Cl)Cl,,,,val
US06277872B1,BrCCBr.Oc1ccccc1-c1nc(-c2ccccc2)no1>>BrCCOc1ccccc1-c1nc(-c2ccccc2)no1,,CCC(C)=O,,[I-].[K+],,val
US06537948B1,COC(=O)C(C)Oc1nc(C)ncc1O.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(F)c([N+](=O)[O-])cc2F)c1=O>>COC(=O)C(C)Oc1nc(C)ncc1Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100227859A1,O=S(Cl)Cl.O=[N+]([O-])c1ccc2c(c1)sc1ccc(S(=O)(=O)O)cc12>>O=[N+]([O-])c1ccc2c(c1)sc1ccc(S(=O)(=O)Cl)cc12,CN(C)C=O,,,,,val
US05276159,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.OC1CCCc2cnc3cc(OCc4ccccc4)ccc3c21>>CC(C)(C)[Si](C)(C)OC1CCCc2cnc3cc(OCc4ccccc4)ccc3c21,,ClCCl,,Cc1cccc(C)n1,,val
US05506267,CC(C)(C)OC(=O)CCSCC(COC(=O)CCCCCCCCCCCc1ccccc1)OC(=O)CCCCCCCCCCCc1ccccc1>>O=C(O)CCSCC(COC(=O)CCCCCCCCCCCc1ccccc1)OC(=O)CCCCCCCCCCCc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030114666A1,C[C@H](NC(=O)OC(C)(C)C)[C@@H]1CCNC1.O=c1[nH]c(=O)n(C2CC2)c2c(OC(F)F)c(F)c(F)cc12>>C[C@H](NC(=O)OC(C)(C)C)[C@@H]1CCN(c2c(F)cc3c(=O)[nH]c(=O)n(C4CC4)c3c2OC(F)F)C1,,CS(C)=O,,[Cl-].[NH4+],,val
US20120184543A1,C=CCc1c(C(=O)OCc2ccccc2)ccc([N+](=O)[O-])c1O.O=C(OO)c1cccc(Cl)c1>>O=C(OCc1ccccc1)c1ccc([N+](=O)[O-])c2c1CC(CO)O2,,ClCCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20110319403A1,CC1Oc2cc(Br)ccc2NC1=O>>CC1CNc2ccc(Br)cc2O1,,C1CCOC1,,B,CSC,val
US20090312381A1,CCOC(=O)CCl.O=c1[nH]nc(-c2ccc(Cl)cc2)n1C1CC1>>CCOC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C2CC2)c1=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150023916A1,CCOc1ccc(Nc2ccc(Br)cc2N)cc1.N=CN>>CCOc1ccc(-n2cnc3cc(Br)ccc32)cc1,,CCO,,CC(=O)O,,val
US20020019389A1,O=C(O)C1(c2ccccc2)CCNCC1.O=C([O-])N(c1ccccc1)C(c1ccccc1)c1ccccc1>>O=C(NC(c1ccccc1)c1ccccc1)N1CCC(C(=O)O)(c2ccccc2)CC1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20060293337A1,N[C@@H]1CCNC1.O=C(CC1CCCCC1)Nc1c(Cl)ccc2nc(Cl)ccc12>>N[C@@H]1CCN(c2ccc3c(NC(=O)CC4CCCCC4)c(Cl)ccc3n2)C1,,CC#N,,CCN(CC)CC,,val
US20100069384A1,NC1CCCC1.O=C(Cl)c1ccc(S(=O)(=O)Cl)cc1>>O=C(NC1CCCC1)c1ccc(S(=O)(=O)Cl)cc1,,ClCCl,,,,val
US20150018547A1,COC(=O)CC(=O)CCl.COc1cc(S)cc(C(F)(F)F)c1>>COC(=O)CC(=O)CSc1cc(OC)cc(C(F)(F)F)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04294960,CCCCCCCCBr.CCOC(=O)C(=NO)C(C)=O>>CCCCCCCCON=C(C(C)=O)C(=O)OCC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04774254,CCOC(=O)c1cnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N>>Nc1c(C(=O)O)cnn1-c1c(Cl)cc(C(F)(F)F)cc1Cl,,O,,CCO,[Na+].[OH-],val
US05661183,ClCc1ccccc1.O=[N+]([O-])c1cc2c(c(Cl)c1O)CCCC2>>O=[N+]([O-])c1cc2c(c(Cl)c1OCc1ccccc1)CCCC2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US03954753,C1CCNC1.COC(=O)c1nc(Cl)cnc1N>>Nc1ncc(Cl)nc1C(=O)N1CCCC1,,CO,,,,val
US20050215572A1,CC(C)(C#N)c1ccc(N)cc1.Clc1cccnc1N1CCc2c(Cl)ncnc2C1>>CC(C)(C#N)c1ccc(Nc2ncnc3c2CCN(c2ncccc2Cl)C3)cc1,,CC#N,,,,val
US20160272628A1,CNC(=O)C(O)CN1C(C)c2cc(-c3cn(C(=O)OC(C)(C)C)c4cc(F)ccc34)ccc2S1(=O)=O>>CNC(=O)C(O)CN1C(C)c2cc(-c3c[nH]c4cc(F)ccc34)ccc2S1(=O)=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030187026A1,CC(C)(C)OC(=O)n1nc(-c2ccncc2)c2cc(O[Si](C)(C)C(C)(C)C)cnc21>>CC(C)(C)OC(=O)n1nc(-c2ccncc2)c2cc(O)cnc21,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04423047,Clc1cnc(SCc2ccccc2)nc1.O=C(OO)c1cccc(Cl)c1>>O=S(Cc1ccccc1)c1ncc(Cl)cn1,,ClCCl,,CC(C)O,,val
US20040204586A1,CC(=O)O.N#Cc1c(Cl)nc2ccccc2c1Cl>>N#Cc1c(Cl)c2ccccc2[nH]c1=O,,CC(=O)O,,C,O=C[O-].[NH4+],val
US20150299189A1,CC(C)Cn1ccc2c(Nc3ncc(C4CC4)cc3C(=O)OC(C)(C)C)cccc21>>CC(C)Cn1ccc2c(Nc3ncc(C4CC4)cc3C(=O)O)cccc21,,ClCCl,O=C(O)C(F)(F)F,,,val
US20150322013A1,CC1(C)CCc2cccc(N)c2C1.O=C(Cl)c1cccnc1C(F)F>>CC1(C)CCc2cccc(NC(=O)c3cccnc3C(F)F)c2C1,,C1CCOC1,,CCN(CC)CC,,val
US20080274907A1,COc1ccc(N(C)C)c(NC(C)=O)c1>>CCNc1cc(OC)ccc1N(C)C,,C1CCOC1,,CO,,val
US20120142717A1,COC(=O)C(C=O)Cc1cnn(C)c1.N=C(N)OCCc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1>>Cn1cc(Cc2c[nH]c(OCCc3ccc(Oc4ccc(C(F)(F)F)cc4)cc3)nc2=O)cn1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20120010228A1,CC(C)(C)OC(=O)N1CCC2(CC1)C(=O)N(Cc1ccc(NS(C)(=O)=O)cc1)CN2c1ccccc1.Cl>>CS(=O)(=O)Nc1ccc(CN2CN(c3ccccc3)C3(CCNCC3)C2=O)cc1.Cl,,C1COCCO1,,,,val
US06403791B1,COc1cccc2oc(SC)nc12.O=C1CCC(=O)N1Br>>COc1ccc(Br)c2oc(SC)nc12,,CC#N,,,,val
US05599986,Cl.O=CN(C=O)C/C(=C/F)CCc1ccc(F)cc1>>Cl.NC/C(=C/F)CCc1ccc(F)cc1,,Cc1ccccc1,,CCO,O,val
US20120252815A1,CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccc4c(c3)C(C)(C)CCC4(C)C)no2)CC1>>CC1(C)CCC(C)(C)c2cc(-c3cc(N4CCNCC4)on3)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120108583A1,CC1(C)Cc2c(c(C(=O)Nc3ccc(C(F)(F)F)cn3)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1.CS(=O)(=O)O>>CC1(C)Cc2c(c(C(=O)Nc3ccc(C(F)(F)F)cn3)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1.CS(=O)(=O)O,,CC(C)=O,,,,val
US20120009151A1,Cc1ccc(CNc2nc(Nc3cccc([N+](=O)[O-])c3)nc(OCC(F)(F)F)n2)o1>>Cc1ccc(CNc2nc(Nc3cccc(N)c3)nc(OCC(F)(F)F)n2)o1,[Ni],CCO,O,NN,,val
US20100317704A1,O=C(CBr)Nc1cccc(C(F)(F)F)c1.O=C1NC2(CCCC2)N=C1c1ccc(-c2ccccn2)cc1>>O=C(CN1C(=O)C(c2ccc(-c3ccccn3)cc2)=NC12CCCC2)Nc1cccc(C(F)(F)F)c1,,CN(C)C=O,CO,[H-].[Na+],,val
US20070185079A1,COc1ccc2c(C)cc(N[C@H]3CC[C@H](N)C3)nc2c1.Cn1cc(C=O)c2ncccc21>>COc1ccc2c(C)cc(N[C@H]3CC[C@H](NCc4cn(C)c5cccnc45)C3)nc2c1,,CO,O,Cl,[Na+].[OH-],val
US04618677,CCCCCCN=C=O.Cl.Cl.SCCCN1CCN(CC=Cc2ccccc2)CC1>>CCCCCCNC(O)=[SH]CCCN1CCN(CC=Cc2ccccc2)CC1.Cl.Cl,,ClCCl,,CCN(CC)CC,,val
US20110275611A1,N#Cc1c(F)cc(Br)cc1F.OCc1ccccc1>>N#Cc1c(F)cc(Br)cc1OCc1ccccc1,,C1CCOC1,,O,[H-].[Na+],val
US04709081,C=O.CO.O=Cc1cccc(Br)c1>>CC(=O)OCc1cccc(Br)c1,,O,,Cl,[K+].[OH-],val
US20120220588A1,CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3ccc([N+](=O)[O-])cc23)c1>>CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3ccc(N)cc23)c1,[Pd],CO,,,,val
US20160016908A1,CC(=O)N1c2ccc(N3CCC(NC(=O)OC(C)(C)C)CC3)cc2[C@H](Nc2ccccc2)[C@@H](C)[C@@H]1C.Cl>>CC(=O)N1c2ccc(N3CCC(N)CC3)cc2[C@H](Nc2ccccc2)[C@@H](C)[C@@H]1C.Cl,,CO,,C1COCCO1,,val
US20060293352A1,CC(C)(Oc1ccc(Cl)cc1OCc1ccccc1)C(=O)O>>CC(C)(Oc1ccc(Cl)cc1O)C(=O)O,[Pd],CCOC(C)=O,,,,val
US20130281460A1,CCCS.Cc1cc(-c2cnc3c(NCC(C)(C)O)nc(Br)cn23)ccc1C(=O)NC1CC1>>CCCSc1cn2c(-c3ccc(C(=O)NC4CC4)c(C)c3)cnc2c(NCC(C)(C)O)n1,,CS(C)=O,,[H-].[Na+],,val
US20090099250A1,COc1ccc(B(O)O)cc1.COc1ccc2c(c1)CCCC(OS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)=C2>>Oc1ccc(C2=Cc3ccc(O)cc3CCC2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20100130506A1,CC(C)(C)O.O=C(O)CCc1ccc(O)cc1>>CC(C)(C)OC(=O)CCc1ccc(O)cc1,,CN(C)C=O,O,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20080194562A1,COCCCl.COc1cccc(F)c1C(=O)O>>COCCOc1cccc(F)c1C(=O)OC,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20110263626A1,CC(=NO)c1ccc(Oc2ccc(Cl)cc2F)cc1>>CC(N)c1ccc(Oc2ccc(Cl)cc2F)cc1,[Ni],CO,,N,[H][H],val
US20110021522A1,COc1ccc(-c2cccc(N)c2)cc1C.O=C(O)c1cc2cccc(OC(F)(F)F)c2oc1=O>>COc1ccc(-c2cccc(NC(=O)c3cc4cccc(OC(F)(F)F)c4oc3=O)c2)cc1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150344429A1,NC(=O)CC1(N)COC1.O=C(O)c1cc(Cl)c(C2CC2)cn1>>NC(=O)CC1(NC(=O)c2cc(Cl)c(C3CC3)cn2)COC1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20150031708A1,COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)cnc1OC.Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1Cl>>COC(=O)c1cc(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)ccc2C)cnc1OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20010006969A1,C1CCNCC1.O=P(Cl)(Cl)Cl.O=c1[nH]c(=O)c2cc([N+](=O)[O-])ccc2[nH]1>>O=[N+]([O-])c1ccc2nc(Cl)nc(N3CCCCC3)c2c1,,O,,,,val
US20100144787A1,C=C(C)B1OC(C)(C)C(C)(C)O1.Cc1c(Cc2ccc(-n3cccn3)cc2)c(Cl)nc2c(F)ccc(O)c12>>C=C(C)c1nc2c(F)ccc(O)c2c(C)c1Cc1ccc(-n2cccn2)cc1,,CN(C)C=O,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20080045496A1,O=C(NC1CC1)c1cc([N+](=O)[O-])n[nH]1>>Nc1cc(C(=O)NC2CC2)[nH]n1,O=[Pt]=O,CCO,,,,val
US05037824,C1COCCN1.Cc1nc(-c2ccccc2)cc(-c2cccc(C#N)c2)c1NC(=O)CCCl>>Cc1nc(-c2ccccc2)cc(-c2cccc(C#N)c2)c1NC(=O)CCN1CCOCC1,,C1CCOC1,ClCCl,,,val
US20020049328A1,CC(C)(C)C(=O)Cl.C[C@@H](N)c1ccccc1>>C[C@@H](NC(=O)C(C)(C)C)c1ccccc1,,O,,[Na+].[OH-],,val
US20100041634A1,COc1cc(N2CCCC2)ncc1[N+](=O)[O-]>>COc1cc(N2CCCC2)ncc1N,[Pd],,,,,val
US20060100207A1,CCC(C(=O)Cl)C(=O)Cl.Nc1cccc(C(F)(F)F)c1.O>>CCOC(=O)CC(=O)Nc1cccc(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,,val
US20120134934A1,CC(C)(C)OC(=O)NC(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1F.O=C(CBr)c1ccccc1>>CC(C)(C)OC(=O)NC(C(=O)O[C@H]1C[N+]2(CC(=O)c3ccccc3)CCC1CC2)c1ccccc1F.[Br-],,CC#N,CCOC(C)=O,,,val
US20120142667A1,COc1cc(OCCO)ccc1[N+](=O)[O-]>>COc1cc(OCCO)ccc1N,[Pd],CO,,,,val
US04435406,CC1Oc2ccccc2O1.O=[N+]([O-])O>>CC1Oc2ccc([N+](=O)[O-])cc2O1,,CC(=O)O,,,,val
US20100048901A1,CCN(CC)c1ccc(C=O)c(O)c1.OCCBr>>CCN(CC)c1ccc(C=O)c(OCCO)c1,,CN(C)C=O,,[H-].[Na+],,val
US20080287475A1,CC(C)Oc1cc(Nc2nc(Cl)ncc2Cl)n[nH]1.CC(N)c1ncc(F)cn1>>CC(C)Oc1cc(Nc2nc(NC(C)c3ncc(F)cn3)ncc2Cl)n[nH]1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US04319913,CCOC(=O)NCc1ccccc1P(C)(=O)OCC>>CCOC(=O)N1Cc2ccccc2P1(C)=O,,ClC(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20140011795A1,NC(=O)c1cnn2cc(Br)cc2c1Cl.NC12CC3CC(O)(C1)CC(O)(C3)C2>>NC(=O)c1cnn2cc(Br)cc2c1NC12CC3CC(O)(CC(O)(C3)C1)C2,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20050107403A1,CC(C)N=C(NC(C)C)OC(C)(C)C.O=C(O)c1cc(Cl)nc(Cl)c1>>CC(C)(C)OC(=O)c1cc(Cl)nc(Cl)c1,,C1CCOC1,,,,val
US20110224155A1,CCCNC(=O)C(C)(C)CO.N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-]>>CCCNC(=O)C(C)(C)COc1cccc([N+](=O)[O-])c1C#N,,C1CCOC1,,[H-].[Na+],,val
US20150284384A1,CS(=O)(=O)Cl.Cc1cc(C#N)cc2nc(CO)c(CC3CCC(F)(F)CC3)n12>>Cc1cc(C#N)cc2nc(COS(C)(=O)=O)c(CC3CCC(F)(F)CC3)n12,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20120046307A1,Cl.Nc1ccccc1N.O=C1CC(c2ccc3ccccc3c2)CC(=O)O1>>Cl.O=C(O)CC(Cc1nc2ccccc2[nH]1)c1ccc2ccccc2c1,,C1COCCO1,ClCCl,,,val
US20080227783A1,Nc1ccc(Nc2nccs2)cc1.O=C(Cl)c1ccccc1>>O=C(Nc1ccc(Nc2nccs2)cc1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20150148311A1,O=C(Cl)C(=O)Cl.O=C(O)c1cccc(=O)n1Cc1cc(Cl)ccc1Cl>>O=C(Cl)c1cccc(=O)n1Cc1cc(Cl)ccc1Cl,,ClCCl,,,,val
US20080214495A1,CC(C)(C)OC(=O)N1CCN(C(=O)C2CCN(c3ccc(=O)[nH]n3)CC2)CC1.Cl>>Cl.O=C(C1CCN(c2ccc(=O)[nH]n2)CC1)N1CCNCC1,,CO,,,,val
US20090186870A1,CC(C)(C)OC(=O)N1CCC[C@H](COc2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(C)(=O)=O)cc4s3)c2)C1>>CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(OC[C@H]4CCCNC4)ccc3Cl)sc2c1,,CO,,CC(=O)Cl,,val
US05246953,CC1(C)CCCC1=O.O=Cc1ccc(Cl)cc1>>CC1(C)CCC(=Cc2ccc(Cl)cc2)C1=O,,CCO,,[Na+].[OH-],,val
US20090312569A1,C=C(C)C.O=C(O)C1CCCCC1>>CC(C)(C)OC(=O)C1CCCCC1,,O,,ClCCl,O=C([O-])O.[Na+],val
US20100311714A1,CN.Fc1cncc(Br)c1>>CNc1cncc(Br)c1,,CN1CCCC1=O,,O=C([O-])O.[Na+],,val
US20110124636A1,CC(C)(C)OC(=O)N1[C@H](CN)C[C@@H]2C[C@@H]21.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1[C@H](CNC(=O)C(F)(F)F)C[C@@H]2C[C@@H]21,,ClCCl,,,,val
US20030199520A1,CC(C)(C)OC[C@@H](NC(=O)OC(C)(C)C)C(=O)O.CC(C)OC(=O)N=NC(=O)OC(C)C.O=C1NC(=O)c2ccccc21>>CC(C)(C)OC(=O)N[C@H](CN1C(=O)c2ccccc2C1=O)C(=O)OC(C)(C)C,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060287343A1,CN1CCNCC1.O=Cc1ccc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)nc1>>CN1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc([N+](=O)[O-])cc5F)c4s3)nc2)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04668686,CCOP(=O)(OCC)C1NC(=O)NC1=O.Cc1ccc([N+](=O)[O-])c(C=O)c1C>>Cc1ccc([N+](=O)[O-])c(C=C2NC(=O)NC2=O)c1C,,CCO,O,[Na],,val
US20070287711A1,Brc1ccc(-c2nnn[nH]2)cc1.COc1ccccc1-c1nn(COCC[Si](C)(C)C)c2ncc(B3OC(C)(C)C(C)(C)O3)cc12>>COc1ccccc1-c1n[nH]c2ncc(-c3ccc(-c4nnn[nH]4)cc3)cc12,,C1CCOC1,CC#N,,,val
US04239902,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O.Oc1ccc2ccccc2c1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)Oc1ccc2ccccc2c1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100240898A1,Brc1cccc2cccnc12.ClP(c1ccccc1)c1ccccc1>>c1ccc(P(c2ccccc2)c2cccc3cccnc23)cc1,,C1CCOC1,,[Li]CCCC,,val
US04149413,O=S(=O)(Oc1ccc(-c2ccc(Br)cc2)cc1)c1ccccc1>>Oc1ccc(-c2ccc(Br)cc2)cc1,,C1COCCO1,O,CCO,[Na+].[OH-],val
US20110245205A1,CN=C=O.Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3(O)CCNCC3)s2)c1>>CNC(=O)N1CCC(O)(c2ncc(-c3cc(C)cc(Nc4nccc(C(F)(F)F)n4)c3)s2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05059611,CC[Si](CC)(CC)c1cc(CCC(=O)OC)co1>>CC[Si](CC)(CC)c1cc(CCCO)co1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04113943,NC(=O)C(=O)NC(C(=O)OC(c1ccccc1)c1ccccc1)c1ccccc1>>NC(=O)C(=O)NC(C(=O)O)c1ccccc1,,CC(=O)O,,Cl,,val
US20060111347A1,C1CCNCC1.O=Cc1ccc2c(c1[N+](=O)[O-])CCC[C@H]2NC(=O)C(F)(F)F>>O=C(N[C@@H]1CCCc2c1ccc(CN1CCCCC1)c2[N+](=O)[O-])C(F)(F)F,,CC(=O)O,ClCCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20130204001A1,CCCCCCCCCN>>CCCCCCCCC#N,[Ni],O,,,,val
US05200522,Cc1cc(Cl)nc(Cl)c1C#N.O=S(=O)(O)O>>Cc1cc(Cl)nc(Cl)c1C(N)=O,,O,,[Na+].[OH-],,val
US05208247,CC(=O)OC(C)=O.CCCCCCCCCCCCCCCCOc1ccc(OCC(=O)NCc2ccccn2)cc1>>CCCCCCCCCCCCCCCCOc1ccc(OCC(=O)N(Cc2ccccn2)C(C)=O)cc1,,O,,c1ccncc1,,val
US20160002248A1,Ic1cc2cc[nH]c2nn1.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(c1ccccc1)n1ccc2cc(I)nnc21,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120022283A1,C#CCC[C@@H](C=C)O[Si](C)(C)C(C)(C)C.CI>>C=C[C@H](CCC#CC)O[Si](C)(C)C(C)(C)C,,C1CCOC1,,[Li]CCCC,,val
US06100258,CCN(Cc1cc(Br)ccc1O)c1ccc(C(N)=O)nn1>>CCN(Cc1cc(Br)ccc1O)c1ccc(C#N)nn1,,C1CCOC1,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US20090209757A1,CCCCCCCCCCCCCCCC(=O)Cl.CN(C)C=O.Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O>>CCCCCCCCCCCCCCCC(=O)O.Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O,,CN(C)C=O,,[H-].[Na+],,val
US20140213571A1,ClCI.Oc1ccc(Cl)nc1-c1cc2ccccc2[nH]1>>Clc1ccc2c(n1)-c1cc3ccccc3n1CO2,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20130065880A1,Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)O)c[nH]4)c3)cc2F)c1.NCCCN1CCCC1>>Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)NCCCN5CCCC5)c[nH]4)c3)cc2F)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110319378A1,C=C(C)C.CCOC(=O)[C@H](CC)N1C(=O)[C@@H](CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1>>CCOC(=O)[C@H](CC)N1C(=O)[C@@H](CC(=O)OC(C)(C)C)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1,,ClCCl,,O=S(=O)(O)O,,val
US20050282827A1,CCOC(=O)c1cnn2ccc(-c3ccc(Cl)cc3)nc12>>O=C(O)c1cnn2ccc(-c3ccc(Cl)cc3)nc12,,CO,O,[Na+].[OH-],,val
US04381398,CCOC(=O)Cc1ccc(OCC(O)CNC(C)CCc2ccccc2)cc1.N>>CC(CCc1ccccc1)NCC(O)COc1ccc(CC(N)=O)cc1,,CCO,,,,val
US20070105904A1,C#Cc1ccc(N)nc1N.ON=C(Cl)Cc1ccc(OCc2ccc(F)cc2)nc1>>Nc1ccc(-c2cc(Cc3ccc(OCc4ccc(F)cc4)nc3)no2)c(N)n1,,O,,C1CCOC1,CCN(CC)CC,val
US20130071327A1,CCOC(=O)/C(=C\C[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)CCCF>>CC(C)(C)OC(=O)N[C@@H](C/C=C(/CCCF)C(=O)O)C(=O)O,,CCO,O,Cl,[Li+].[OH-],val
US05344843,COC(=O)C(=O)c1ccc(C#CCNC(=O)c2ccc3ccccc3c2)cc1>>O=C(O)C(=O)c1ccc(C#CCNC(=O)c2ccc3ccccc3c2)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20150148342A1,Cn1cc(-c2ccc3c([nH]c(=O)n3C)c2Oc2ccc(Cl)cc2)c2ccn(COCC[Si](C)(C)C)c2c1=O>>Cn1cc(-c2ccc3c([nH]c(=O)n3C)c2Oc2ccc(Cl)cc2)c2cc[nH]c2c1=O,,CO,ClCCl,NCCN,O=C(O)C(F)(F)F,val
US20030125392A1,CC(=O)CC(=O)N(c1ccc(Nc2ccccc2)cc1)C(C)C.N>>C/C(N)=C/C(=O)N(c1ccc(Nc2ccccc2)cc1)C(C)C,,CCOC(C)=O,,CC(=O)O,,val
US20070043080A1,CCn1c2ccccc2c2cc(C=O)ccc21.O=C(Nc1cccc(C2CCNCC2)c1)C1CC1>>CCn1c2ccccc2c2cc(CN3CCC(c4cccc(NC(=O)C5CC5)c4)CC3)ccc21,,CC(=O)O,,,,val
US05840716,O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>FC(F)(F)Oc1ccc(S)cc1,[Zn],O,O=S(=O)(O)O,CCOC(C)=O,,val
US20100004483A1,COC(=O)Cc1ccc(OC(C)C)cc1.COC(=O)c1cc(OC)cc(OC)c1>>COC(=O)C(C(=O)c1cc(OC)cc(OC)c1)c1ccc(OC(C)C)cc1,,Cc1ccccc1,O,CC(=O)O,[H-].[Na+],val
US20070167488A1,COC(=O)CCl.O=Cc1c[nH]c2ccccc12>>COC(=O)Cn1cc(C=O)c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US04010177,C1COCCN1.O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1)=NCc1nnc(CCl)n1-2>>O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1)=NCc1nnc(CN3CCOCC3)n1-2,,C1CCOC1,,[I-].[K+],,val
US05610144,CCOC(=O)c1cccc(NC(=O)NCC(=O)N2C(C(=O)OC(C)(C)C)CCC2c2ccccc2F)c1.CO>>CC(C)(C)OC1C(=C=O)CC(c2ccccc2F)N1C(=O)CNC(=O)Nc1cccc(C(=O)O)c1,,O,,[K+].[OH-],,val
US20030064962A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@@]1(CC(=O)OCc2ccccc2)C[C@@H](C(=O)Nc2ccccc2)n2c1ncc(N(Cc1cccc(C(F)(F)F)c1)C(=O)OCc1ccccc1)c2=O>>CC(C)(C)OC(=O)N(C(=O)[C@@H]1C[C@@](C)(CC(=O)OCc2ccccc2)c2ncc(N(Cc3cccc(C(F)(F)F)c3)C(=O)OCc3ccccc3)c(=O)n21)c1ccccc1,CN(C)c1ccncc1,CC#N,CCOC(C)=O,,,val
US05854353,Br[Mg]c1ccccc1.CC(=O)c1ccccc1>>C=C(c1ccccc1)c1ccccc1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20030092770A1,C[Al](C)C.c1ccc([C@@H]2CO2)cc1>>C[C@@H](CO)c1ccccc1,,Cc1ccccc1,,,,val
US20130210844A1,O=[N+]([O-])c1cccc2c(Nc3cccc(C(F)(F)F)c3)ncnc12>>Nc1cccc2c(Nc3cccc(C(F)(F)F)c3)ncnc12,[Fe],CCO,O,[Cl-].[NH4+],,val
US20110306588A1,CC1(C)OB(C2=CCC(O[Si](C)(C)C(C)(C)C)CC2)OC1(C)C.O=C(c1nc2ccccc2[nH]1)N1CC(Oc2nccnc2Cl)C1>>CC(C)(C)[Si](C)(C)OC1CC=C(c2nccnc2OC2CN(C(=O)c3nc4ccccc4[nH]3)C2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20120149632A1,CC(C)(C)OC(=O)NCCCN(CCCCN(CCCNCC(=O)OCc1ccccc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NCCCN(CCCCN(CCCN(CC(=O)OCc1ccccc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,,CO,,,,val
US20020173506A1,COC(=O)CC(C)c1ccc(NC(=O)Cc2ccc([N+](=O)[O-])c(OC(C)=O)c2)nc1>>COC(=O)CC(C)c1ccc(NC(=O)Cc2ccc([N+](=O)[O-])c(O)c2)nc1,,ClCCl,,C1CCNCC1,,val
US20090012055A1,CI.COCCCN1C(=O)COc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OC[C@H](O)COc4ccccc4)cc3)cc21>>COCCCN1C(=O)COc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OC[C@@H](COc4ccccc4)OC)cc3)cc21,,C1CCOC1,,[H-].[Na+],,val
US04122274,CCc1ccc(C(=O)O)nc1.OCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCc1ccc(NC(=O)OCc2ccccc2)nc1,,C1COCCO1,,CCN(CC)CC,,val
US20050054851A1,CC(C)(C)Cn1c(CBr)cc2cnc(C#N)nc21.COc1ccccc1N1CCNCC1>>COc1ccccc1N1CCN(Cc2cc3cnc(C#N)nc3n2CC(C)(C)C)CC1,C1COCCOCCOCCOCCOCCO1,CN(C)C=O,,[H-].[Na+],,val
US05739338,Cc1ccc(N2CCC(C)(C)c3ccc(C#C[Si](C)(C)C)cc32)cc1>>C#Cc1ccc2c(c1)N(c1ccc(C)cc1)CCC2(C)C,,C1CCOC1,CO,O=C([O-])[O-].[K+].[K+],,val
US20100160303A1,Cc1c(Br)cccc1CO>>Cc1c(Br)cccc1C=O,,C1CCOC1,CCOCC,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20080188557A1,CC(=O)O.CCCc1ccc(OC)c(OC)c1>>COc1ccc(C=CC=O)cc1OC,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US05744488,COC(=O)CCn1c(C)c(Cc2cccnc2)c2cc(/C=C/C(=O)O)ccc21>>COC(=O)CCn1c(C)c(Cc2cccnc2)c2cc(CCC(=O)O)ccc21,[Pd],C1CCOC1,CO,O=C[O-].[NH4+],,val
US20160145304A1,CC(=O)Cl.COc1cccc(C=O)c1O>>COc1cccc(C=O)c1OC(C)=O,,ClCCl,,c1ccncc1,,val
US04411911,CCCC(=O)C=[N+]=[N-].Cc1ccccc1S(=O)(=O)O>>CCCC(=O)COS(=O)(=O)c1ccccc1C,,ClC(Cl)Cl,,,,val
US20120053147A1,COCC(=O)Cl.Cc1c(Cl)cccc1CNc1nc(N2CCOCC2)sc1C(N)=O>>COCc1nc(=O)c2sc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1C,,C1CCOC1,,,,val
US20160152624A1,COC(=O)Cc1c(C)nc(-c2ccc(OC)c(F)c2)nc1Cl.N>>COc1ccc(-c2nc(C)c3c(n2)NC(=O)C3)cc1F,,C1CCOC1,,,,val
US20040157886A1,O=C1COc2cc(NC(=O)C(=O)O)ccc2N1.c1ccc(COC2CCNCC2)cc1>>O=C1COc2cc(NC(=O)C(=O)N3CCC(OCc4ccccc4)CC3)ccc2N1,,CCOCC,,,,val
US06229011B1,COC(=O)[C@H](Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1)NC(=O)c1ccc(C(=O)Nc2cccc(O)c2)cc1Cl>>O=C(Nc1cccc(O)c1)c1ccc(C(=O)N[C@@H](Cc2ccc(NC(=O)c3c(Cl)cccc3Cl)cc2)C(=O)O)c(Cl)c1,,C1CCOC1,CO,[Li+].[OH-],,val
US05106861,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H]1Cc2ccccc2[C@@H](Cl)[C@@H]1O>>CC(C)(C)OC(=O)N[C@@H]1Cc2ccccc2[C@@H](Cl)[C@@H]1O,,CO,,CCN(CC)CC,Cl,val
US20030064991A1,CS(=O)(=O)Cl.Cc1[nH]c2ccc(CCO)cc2c1C(=O)OCc1ccccc1>>Cc1[nH]c2ccc(CCOS(C)(=O)=O)cc2c1C(=O)OCc1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20080275037A1,Cc1ccc(N2CCc3ncnc(Cl)c3C2)c(C#N)c1.NCc1ccc2nccnc2c1>>Cc1ccc(N2CCc3ncnc(NCc4ccc5nccnc5c4)c3C2)c(C#N)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US05597820,CC[C@H]1Oc2cc(C(=O)OC)ccc2N(CC)C1=O>>CC[C@H]1Oc2cc(C(=O)O)ccc2N(CC)C1=O,,Cl,,,,val
US20080176906A1,CCCc1c(C#N)c(-c2ccc(C#N)cc2)c(C)n1Cc1cnc(Cl)c(CO)c1.CS(=O)(=O)O>>CCCc1c(C#N)c(-c2ccc(C#N)cc2)c(C)n1Cc1cnc(Cl)c(CO)c1.CS(=O)(=O)O,,CCOC(C)=O,,,,val
US20060148858A1,CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CO.COC(=O)Cc1cccc(O)c1>>CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1COc1cccc(CC(=O)O)c1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20150353489A1,CCCn1ccc2ccccc21.Cc1ccc(C(=O)/C=C/C(=O)O)c(C)c1>>CCCn1cc(C(CC(=O)c2ccc(C)cc2C)C(=O)O)c2ccccc21,,c1ccccc1,,,,val
US04104316,C=CC(Cl)CCl.CCCCO.CCCC[O-].[Na+]>>C=CC(Cl)CCl.CCCCO.CCCC[O-].[Na+],,CCCCO,,O,[Na+].[OH-],val
US20120214785A1,CCOc1ccc(C#Cc2ccc(C(C)NC(=O)OC(C)(C)C)cc2)cc1>>CCOc1ccc(C#Cc2ccc(C(C)N)cc2)cc1,,CCOC(C)=O,,Cl,,val
US20090143353A1,CNc1ccccn1.Cc1c(-c2ccccc2)c(F)c2oc(Cl)nc2c1C#N>>Cc1c(-c2ccccc2)c(F)c2oc(N(C)c3ccccn3)nc2c1C#N,,CCOC(C)=O,,CCN(C(C)C)C(C)C,ClCCl,val
US04517347,CCCCCCCC/C=C\CCCCCCCC(=O)O.Oc1ccc(O)cc1>>CCCCCCCC/C=C\CCCCCCCC(=O)O.Oc1ccc(O)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04554276,O=Cc1ccc(Cl)cc1.O=P(c1ccccc1)(c1ccccc1)c1ccccc1.[CH2-]S(C)=O>>O=C(O)CCCC=Cc1ccc(Cl)cc1,,CS(C)=O,O,Cl,,val
US05998433,COC(=O)c1cc2c(o1)CNCC2.O=C(O)c1ccc(C(=O)c2ccccc2)cc1>>COC(=O)c1cc2c(o1)CN(C(=O)c1ccc(C(=O)c3ccccc3)cc1)CC2,,ClCCl,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20140088094A1,C1CCNC1.CS(=O)(=O)OC[C@H]1CN(S(=O)(=O)c2cccc(C#N)c2)c2cc(NC(=O)c3c(F)cccc3Cl)ccc2O1>>N#Cc1cccc(S(=O)(=O)N2C[C@H](CN3CCCC3)Oc3ccc(NC(=O)c4c(F)cccc4Cl)cc32)c1,,CN(C)C=O,,,,val
US06350749B1,Cc1ccnc2c1C(=O)CC(c1ccccc1F)C2.Cl.N=C(N)NN>>Cc1ccnc2c1C(=NNC(=N)N)CC(c1ccccc1F)C2.Cl,,CCO,,Cl,O,val
US20110207699A1,C1CC2(CCN1)OCCO2.O=[N+]([O-])c1cc(F)c(F)c(F)c1>>O=[N+]([O-])c1cc(F)c(N2CCC3(CC2)OCCO3)c(F)c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20030105099A1,CCOC(=O)C(CCCc1ccccc1)(CC(=O)N1CCOCC1)C(=O)OCC>>CCOC(=O)C(CCCc1ccccc1)(CC(=O)N1CCOCC1)C(=O)O,,CCO,,O,,val
US20090149439A1,CCOC(=O)COCNC(=O)c1cc(C)c(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(F)cc2)cn1>>Cc1cc(C(=O)NCOCC(=O)O)ncc1C(c1cc(F)ccc1F)S(=O)(=O)c1ccc(F)cc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20150045349A1,CN1CCNCC1.O=Cc1cnc(Cl)cn1>>CN1CCN(Cc2cnc(Cl)cn2)CC1,,CC#N,,O=C([O-])O.[Na+],,val
US04837341,CC(C)(C)OC1OC(=O)CC(C)(C)C1O.CS(=O)(=O)Cl>>CC(C)(C)OC1OC(=O)CC(C)(C)C1OS(C)(=O)=O,,Cl,,c1ccncc1,,val
US05534481,CC(C)(C)N.Cn1nc(S(=O)(=O)Cl)c2c(F)cccc21>>Cn1nc(S(=O)(=O)NC(C)(C)C)c2c(F)cccc21,,C1CCOC1,,O,,val
US05079260,Cc1cccc2c1C(CCC1OCCO1)c1ccccc1-2>>Cc1cccc2c1C(CCC(=O)O)c1ccccc1-2,,CC(C)=O,,CCCCCC,CCOC(C)=O,val
US05272163,N#Cc1cc([N+](=O)[O-])ccc1Sc1ccccc1>>N#Cc1cc(N)ccc1Sc1ccccc1,,CCO,,[Na+].[OH-],,val
US20070149542A1,CCN1CCC(c2cccc(OS(C)(=O)=O)c2F)CC1>>CS(=O)(=O)Oc1cccc(C2CCNCC2)c1F,,ClCCCl,,CC(Cl)OC(=O)Cl,,val
US20100291003A1,COC(=O)C=Cc1ccc(/C=C(/CO)c2ccc(F)cc2)cc1.NC1CC1>>COC(=O)C=Cc1ccc(/C=C(/CNC2CC2)c2ccc(F)cc2)cc1,,CCOC(C)=O,,CO,[BH4-].[Na+],val
US20120295897A1,O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2C12COc1c(Cl)cc3c(c12)OCCO3>>O=C1Nc2ccccc2C12COc1ccc3c(c12)OCCO3,[Pd],CO,,CCOC(C)=O,[H][H],val
US04041071,CCN.CCOC(=O)/C=C/c1cccc(Br)c1>>CCNC(=O)C=Cc1cccc(Br)c1,,CO,,Cl,C[O-].[Na+],val
US04130646,COc1ccccc1N1CCN(CC2CCc3ccccc3C2O)CC1.Cl>>COc1ccccc1N1CCN(CC2CCc3ccccc3C2O)CC1.Cl,,CCOCC,,,,val
US20130096118A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.Cc1c(-c2n[nH]c(=O)c3[nH]c4cc(Br)ccc4c23)cccc1[N+](=O)[O-]>>CC(=O)c1ccc2c(c1)[nH]c1c(=O)[nH]nc(-c3cccc([N+](=O)[O-])c3C)c12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,CCN(CC)CC,,val
US05849930,CCN1CC(NC(=O)c2ccc(OC/C=C(\C)CCC=C(C)C)cc2)CN1CC.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCN1CC(NC(=S)c2ccc(OC/C=C(\C)CCC=C(C)C)cc2)CN1CC,,Cc1ccccc1,,CCOC(C)=O,,val
US20130102527A1,CON(C)C(=O)[C@H](Cc1ccc(NC(=O)OC(C)(C)C)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21>>CON(C)C(=O)[C@@H](N)Cc1ccc(NC(=O)OC(C)(C)C)cc1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20070197788A1,CO.O=C1OC2CCCC1C2>>COC(=O)[C@H]1CCC[C@@H](O)C1,,CO,,CC(=O)Cl,,val
US20150148311A1,Cc1nn(C)c(Cl)c1C=O.Oc1cc(Cl)ccc1Cl>>Cc1nn(C)c(Oc2cc(Cl)ccc2Cl)c1C=O,[Cu]I,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20080176830A1,CCOC(=O)CN(C)c1cc(-c2ccc(C(F)(F)F)cc2)ccc1[N+](=O)[O-]>>CN1CC(=O)Nc2ccc(-c3ccc(C(F)(F)F)cc3)cc21,[Pd],CO,,[H][H],,val
US07312225B2,Clc1ncc(Br)c(Cl)n1.NCCCCCNS(=O)(=O)c1cccc([N+](=O)[O-])c1>>O=[N+]([O-])c1cccc(S(=O)(=O)NCCCCCNc2nc(Cl)ncc2Br)c1,,CC#N,,CCN(CC)CC,O,val
US20120245172A1,CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(N)cc2)C1.Clc1ncc(Cl)c(Cl)n1>>CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Nc3nc(Cl)ncc3Cl)cc2)C1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20020160997A1,CCI.Oc1ccc2c(c1)cc1n2CCC1>>CCOc1ccc2c(c1)cc1n2CCC1,,CN(C)C=O,,[H-].[Na+],,val
US20100210636A1,COc1ccc(CN2C(=O)OC(CNC(=O)c3ccc(F)cc3)(C(F)(F)F)c3cc(I)ccc32)cc1.c1nc[nH]n1>>O=C1Nc2ccc(-n3cncn3)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1,I[Cu]I,CCOC(C)=O,CN(C)C=O,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20030171411A1,Nc1nccs1.O=C(O)C(OCc1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1>>O=C(Nc1nccs1)C(OCc1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1,,C1CCOC1,,,,val
US20120295903A1,CC(C)(C)OC(=O)NCCBr.Cc1ccc(N)cc1OC1CCCC1>>Cc1ccc(NCCNC(=O)OC(C)(C)C)cc1OC1CCCC1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US20140163000A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.O=[N+]([O-])c1cnccc1Cl>>CC(C)(C)OC(=O)N1CC=C(c2ccncc2[N+](=O)[O-])CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20060094707A1,COC(=O)C(Cc1ccc(OCc2ccccc2)cc1COC(C)=O)NC(=O)OC(C)(C)C>>COC(=O)C(Cc1ccc(OCc2ccccc2)cc1CO)NC(=O)OC(C)(C)C,,CO,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20100105659A1,O=C(NC(=S)Nc1ncc(Sc2ccccn2)cc1Oc1ccccc1)c1ccccc1>>NC(=S)Nc1ncc(Sc2ccccn2)cc1Oc1ccccc1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20120245171A1,Nc1cc(-c2cccc3[nH]ccc23)cc2nn(C3CCCCO3)cc12.O=C(O)c1ccn(CC2CCOCC2)n1>>O=C(Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12)c1ccn(CC2CCOCC2)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US03933906,CC(=O)Nc1ccccc1NS(=O)(=O)c1cc(C(=O)O)c(Nc2ccccc2)c(NCc2ccco2)c1NC(C)=O>>Nc1ccc(Nc2c(NCc3ccco3)cc(C(=O)O)cc2S(=O)(=O)Nc2ccccc2N)cc1,,CC(=O)O,,[Na+].[OH-],,val
US20070244132A1,O=[N+]([O-])c1ccc(F)c(Cl)c1.Oc1ccc(CCCn2ccnc2)cc1>>O=[N+]([O-])c1ccc(Oc2ccc(CCCn3ccnc3)cc2)c(Cl)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040209921A1,CC(=O)c1cc(C)ccn1.CC(C)(C)OC(=O)NCCCCN>>Cc1ccnc(C(C)NCCCCNC(=O)OC(C)(C)C)c1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080045509A1,CC(C)N1CCN(Cc2ccc(F)c(C=O)c2)CC1.CSc1ccc(O)cc1>>CSc1ccc(Oc2ccc(CN3CCN(C(C)C)CC3)cc2C=O)cc1,,CCOCC,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20150126485A1,CC(C)(C)OC(=O)n1cccc1B1OC(C)(C)C(C)(C)O1.O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(Br)c1>>O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccc[nH]2)c1,,CCO,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20090137603A1,NO.O=C(O)CCCOc1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1>>O=C(CCCOc1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1)NO,,C1CCOC1,CC(C)(C)O,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20100144751A1,COCCOc1ccn2c(-c3ccc4cccc(N5CCN(C(=O)OC(C)(C)C)CC5)c4n3)cnc2c1>>COCCOc1ccn2c(-c3ccc4cccc(N5CCNCC5)c4n3)cnc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050182259A1,CCOC(=O)c1cnc2cc(F)c(OC)cc2c1O>>COc1cc2c(O)c(C(=O)O)cnc2cc1F,,O,,Cl,[Na+].[OH-],val
US20040197829A1,CC(C)[Si](Br)(CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(C)C.CCC(O)c1cc(I)n(CC#Cc2ccccc2)c(=O)c1C>>CCC(O[Si](CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(C(C)C)C(C)C)c1cc(I)n(CC#Cc2ccccc2)c(=O)c1C,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20090227640A1,FC(F)(F)c1ccc(-c2ccc(CCl)cc2)cc1.OCc1ccccc1O>>OCc1ccccc1OCc1ccc(-c2ccc(C(F)(F)F)cc2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160002228A1,Cc1ccc(S(=O)(=O)n2cc(CO)c3cc(Br)cnc32)cc1.O=S(Cl)Cl>>Cc1ccc(S(=O)(=O)n2cc(CCl)c3cc(Br)cnc32)cc1,,ClCCl,,,,val
US04925863,Fc1ccc(C2(Cn3cncn3)CO2)c(F)c1.N#Cc1ccc(C=Cc2nc[nH]n2)cc1>>N#Cc1ccc(C=Cc2ncn(CC(O)(Cn3cncn3)c3ccc(F)cc3F)n2)cc1,,CN(C)C=O,O,[H-].[Na+],,val
US20070099944A1,C=C1CC(=O)O1.NC(N)=O.Nc1cc2cn[nH]c2cc1F.O=Cc1ccc(F)cc1>>CC1=C(C(=O)Nc2cc3cn[nH]c3cc2F)C(c2ccc(F)cc2)NC(=O)N1,,CC#N,O,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US20120022123A1,O=C1CN(C(=O)c2cc(Br)c(-c3cccc(Cl)c3)s2)CN1.OB(O)c1ccc(F)c(Cl)c1>>O=C1CN(C(=O)c2cc(-c3ccc(F)c(Cl)c3)c(-c3cccc(Cl)c3)s2)CN1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])O.[Na+],,val
US20120270867A1,N#Cc1cccc(N)c1.O=C([O-])Cc1nc(N2CCOCC2)cc(=O)[nH]1>>N#Cc1cccc(NC(=O)Cc2nc(N3CCOCC3)cc(=O)[nH]2)c1,,CCOC(C)=O,,O,,val
US20150284395A1,N#Cc1cnn2c(=O)cc(-c3ccc4c(c3)OCCO4)[nH]c12.OO>>NC(=O)c1cnn2c(=O)cc(-c3ccc4c(c3)OCCO4)[nH]c12,,CO,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20040082607A1,CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2ccccc2)c2cc(C(N)=NO)ccc2c1=O.CCOC(C)=O>>CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2ccccc2)c2cc(-c3noc(=O)[nH]3)ccc2c1=O,,CCOC(C)=O,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US20070281955A1,O=[N+]([O-])c1cccc(-c2nc3sccn3c2-c2ccnc(N[C@@H]3CCCN(S(=O)(=O)c4ccc(Cl)cc4)C3)n2)c1>>Nc1cccc(-c2nc3sccn3c2-c2ccnc(N[C@@H]3CCCN(S(=O)(=O)c4ccc(Cl)cc4)C3)n2)c1,,CCO,O,Cl,,val
US20120059015A1,NO.O=CC#Cc1ccccc1>>ON=CC#Cc1ccccc1,,O,,CCO,Cl,val
US20060217426A1,COC(=O)c1ccccc1N.COc1ccc(C(=O)Cl)cc1OC>>COC(=O)c1ccccc1NC(=O)c1ccc(OC)c(OC)c1,,ClCCl,,c1ccncc1,,val
US20140309207A1,CC(C)(C)OC(=O)N1CC=C(CNc2ccc(C(F)(F)F)cc2Br)C1>>CC(C)(C)OC(=O)N1CCC2(CNc3ccc(C(F)(F)F)cc32)C1,,c1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US20130102643A1,Br.CCC(C(c1ccc2nc(N)sc2c1)n1ccnc1)N(C)C>>CCC(C(c1ccc2nc(Br)sc2c1)n1ccnc1)N(C)C,,O,,O=N[O-].[Na+],,val
US20100022544A1,O=S(Cl)Cl.OCc1cccc(Nc2ccncc2)n1>>ClCc1cccc(Nc2ccncc2)n1,,ClCCl,,,,val
US20050004167A1,NNC(=O)c1cc2ccccc2o1.O=S(=O)(Cl)c1ccccc1>>O=C(NNS(=O)(=O)c1ccccc1)c1cc2ccccc2o1,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,CN(C)C=O,val
US05268389,CC(C)OC(=O)c1cc(N)ccc1Cl.Cc1oc(C)c(C(=O)Cl)c1C>>Cc1oc(C)c(C(=O)Nc2ccc(Cl)c(C(=O)OC(C)C)c2)c1C,,Cc1ccccc1,,CCN(CC)CC,,val
US20140051697A1,Cc1nocc1C(=O)O.O=C1c2cccn2CC2(c3ccc(OC(F)F)cc3)NCCN12>>Cc1nocc1C(=O)N1CCN2C(=O)c3cccn3CC12c1ccc(OC(F)F)cc1,,ClCCl,c1ccncc1,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20100004250A1,CC(C)C[C@H](N)C(=O)OC1CCCC1.O=C(Cl)CCCBr>>CC(C)C[C@H](NC(=O)CCCBr)C(=O)OC1CCCC1,,ClCCl,,CCN(CC)CC,Cl,val
US20050176722A1,CC(C)(C)OC(=O)N(CCCl)CCCl.COc1cccc(CC#N)c1>>COc1cccc(C2(C#N)CCN(C(=O)OC(C)(C)C)CC2)c1,,C1CCOC1,CS(C)=O,[H-].[Na+],,val
US04703053,COc1c(C(=O)O)oc2ccc(-c3ccccc3)cc12.Nc1nnn[nH]1>>COc1c(C(=O)Nc2nnn[nH]2)oc2ccc(-c3ccccc3)cc12,,C1CCOC1,,,,val
US20050009777A1,ClCCl.Nc1ccccc1N.O=C(O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O.O=C(O)c1ccccc1.O=C(O)c1ccccc1.O=C(O)c1ccccc1>>Cn1c([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)nc2ccccc21.O=C(O)c1ccccc1.O=C(O)c1ccccc1.O=C(O)c1ccccc1,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20090247559A1,CCO.O=C(O)C1CCN(Cc2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)C1>>CCOC(=O)C1CCN(Cc2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)C1,O=S(=O)(O)O,,,,,val
US05583140,CN1C2CCC(CC2)C1c1cccnc1.O=C(O)/C=C/C(=O)O>>CN1C2CCC(CC2)C1c1cccnc1.O=C(O)/C=C/C(=O)O,,CCO,,,,val
US03983107,CCOC(=O)C1CCNCC1.O=C(NS(=O)(=O)C=Cc1ccccc1)N(c1ccccc1)c1ccccc1>>O=C(O)C1CCN(C(=O)NS(=O)(=O)C=Cc2ccccc2)CC1,,C1CCOC1,CCOCC,CN(C)C=O,,val
US04316839,CNCC(=O)O.O=c1[nH]c2ccc(F)cc2c(=O)o1>>CN1CC(=O)Nc2ccc(F)cc2C1=O,,CS(C)=O,,O,,val
US20150274767A1,CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](n2ccc3c(N)nc(Cl)nc32)O[C@]1(C=O)CO.COP(=O)(OC)C(=[N+]=[N-])C(C)=O>>C#C[C@]1(CO)O[C@@H](n2ccc3c(N)nc(Cl)nc32)C[C@@H]1O[Si](C)(C)C(C)(C)C,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20030022887A1,COc1cc(C=CCO)cc(OC)c1OC>>COc1cc(CCCO)cc(OC)c1OC,[Pd],CCO,,,,val
US20110160199A1,ClCCCCBr.Fc1ccc2c(C3CCNCC3)noc2c1>>Fc1ccc2c(C3CCN(CCCCCl)CC3)noc2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06689922B1,CC(C)(O)CCCCCCc1cccc(C=Cc2cc(OC3CCCCO3)cc(OC3CCCCO3)c2)c1>>CC(C)(O)CCCCCCc1cccc(C=Cc2cc(O)cc(O)c2)c1,,C1CCOC1,O,O=S(=O)(O)O,,val
US20130345194A1,CNS(=O)(=O)N1CCN(c2ncnc3c2ccn3C(=O)OC(C)(C)C)CC12CC2.COC(=O)CCl>>COC(=O)CN(C)S(=O)(=O)N1CCN(c2ncnc3[nH]ccc23)CC12CC2,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20090239880A1,c1ccc(C(=C2CCN(c3nc4ccccc4[nH]3)CC2)c2ccccc2)cc1>>c1ccc(C(c2ccccc2)C2CCN(c3nc4ccccc4[nH]3)CC2)cc1,[Pd],CCO,,[H][H],,val
US20150322111A1,C[C@@H](C(=O)N[C@H](C(=O)N1Cc2cc(OC(=O)c3ccc(C(=O)N[C@H]4C[C@@H](C(=O)N[C@@H]5CCCc6ccccc65)N(C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(C)(C)C)C4)cc3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C)N(C)C(=O)OC(C)(C)C>>CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(OC(=O)c3ccc(C(=O)N[C@H]4C[C@@H](C(=O)N[C@@H]5CCCc6ccccc65)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C4)cc3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030176454A1,O=P(Cl)(Cl)Cl.Oc1ncnc2c1CCOc1ccccc1-2>>Clc1ncnc2c1CCOc1ccccc1-2,,O,,O=C([O-])[O-].[K+].[K+],,val
US04818271,CCCOc1cc(NC(=O)OC(C)(C)C)ccn1>>CCCOc1cc(N)ccn1,,O=C(O)C(F)(F)F,,,,val
US20070232627A1,CC(C)c1ccc2c(Nc3cc(NC(=O)c4ccc(Br)s4)ccc3Oc3ccc(NC(=O)OC(C)(C)C)cc3)ncnc2n1>>CC(C)c1ccc2c(Nc3cc(NC(=O)c4ccc(Br)s4)ccc3Oc3ccc(N)cc3)ncnc2n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20070037786A1,CC(C)(C)OC(=O)NCCN.ClCCl.Nc1cnn2c1NCCC2.O=S(=O)(O)O>>CC(C)(C)OC(=O)NCCNC(=O)Nc1cnn2c1NCCC2,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120319052A1,O=C1CCC(=O)N1Br.c1ccc2c(c1)Sc1cccc3c1N2c1ccccc1S3>>Brc1cc2c3c(c1)Sc1ccccc1N3c1ccccc1S2,,ClC(Cl)Cl,,,,val
US04596872,Br.O=C(c1ccc(Cl)c([N+](=O)[O-])c1)C1CC1>>O=C(CCCBr)c1ccc(Cl)c([N+](=O)[O-])c1,,CC(=O)O,,O=C([O-])[O-].[K+].[K+],,val
US20120115907A1,COc1ccccc1CO.OCCBr>>COc1ccccc1COCCO,,C1CCOC1,O,[H-].[Na+],,val
US04547573,CCOC(CNC#N)OCC.C[Si](C)(C)Cl>>CCOC(CN=C=N[Si](C)(C)C)OCC,,C1CCOC1,,CCN(CC)CC,,val
US06258827B1,CC(C(=O)c1ccc(O[Si](C(C)C)(C(C)C)C(C)C)c(F)c1)N1CCC(O)(c2ccc(Cl)cc2)CC1>>CC(C(O)c1ccc(O[Si](C(C)C)(C(C)C)C(C)C)c(F)c1)N1CCC(O)(c2ccc(Cl)cc2)CC1,,CCO,,[BH4-].[Na+],,val
US20150218106A1,COc1ccc(C=O)c(OC)c1.N#Cc1cn[nH]c1N.[C-]#[N+]C(C)C>>COc1ccc(-c2[nH]c3c(C#N)cnn3c2NC(C)C)c(OC)c1,,CO,,[O-][Cl+3]([O-])([O-])O,,val
US20050070521A1,CC(=O)N1CC(OC(c2ccccc2)(c2ccccc2)c2ccccc2)C1.Cl>>Cl.c1ccc(C(OC2CNC2)(c2ccccc2)c2ccccc2)cc1,,CCOC(C)=O,CO,[Na+].[OH-],,val
US20060287343A1,CC(C)(C)OC(=O)N1CC=C(c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)CC1>>O=[N+]([O-])c1ccc(Oc2ccnc3cc(C4=CCNCC4)sc23)c(F)c1,,ClCCl,,,,val
US20130041007A1,Cc1ccc(S(=O)(=O)n2c3c(c4cc(F)c(Cl)cc42)CCCC3(O[Si](C)(C)C)C(F)(F)F)cc1>>OC1(C(F)(F)F)CCCc2c1[nH]c1cc(Cl)c(F)cc21,,C1CCOC1,O,CCO,[K+].[OH-],val
US20140249104A1,COc1cnc(C(N)=O)c(CC(OC)OC)c1>>COc1cnc2c(=O)[nH]ccc2c1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140249215A1,CN(C)Cc1c(C(=O)NCCOc2ccc(C(=O)NO)cc2)oc2ccccc12.Cc1ccc(S(=O)(=O)O)cc1>>CN(C)Cc1c(C(=O)NCCOc2ccc(C(=O)NO)cc2)oc2ccccc12.Cc1ccc(S(=O)(=O)[O-])cc1,,O,,CC(C)O,,val
US20040198984A1,CN.Cc1cc(Cl)cc2c(=O)oc(-c3cc(Cl)nn3-c3ncccc3Cl)nc12>>CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(Cl)nn1-c1ncccc1Cl,,C1CCOC1,,,,val
US20100056506A1,CO.O[C@@H]1CC[C@@H](Nc2ncc3ccc(F)cc3n2)CC1>>COc1ccc2cnc(N[C@@H]3CC[C@@H](O)CC3)nc2c1,,CO,,C[O-].[Na+],,val
US20070054884A1,BrBr.Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl>>Oc1cc(Cl)c(Br)cc1Oc1ccc(Cl)cc1Cl,,CC(=O)O,O,,,val
US04337353,Cc1c(CC=CCCC(=O)O)cccc1C(=O)c1ccc(Cl)cc1>>Cc1c(CCCCCC(=O)O)cccc1C(=O)c1ccc(Cl)cc1,[Ni],CO,,[H][H],,val
US05019574,O=[N+]([O-])c1c(N2CCCCC2)c[n+]([O-])c2ccccc12>>Nc1c(N2CCCCC2)cnc2ccccc12,[Ni],C1CCOC1,CO,,,val
US20070259898A1,NC1=Nc2cnc(Oc3ccccc3)cc2CN1[C@@H](CCC(=O)N(CCOCc1ccccc1)C1CCC(C(=O)OCc2ccccc2)CC1)C1CCOCC1>>NC1=Nc2cnc(Oc3ccccc3)cc2CN1[C@@H](CCC(=O)N(CCOCc1ccccc1)[C@@H]1CC[C@H](C(=O)O)CC1)C1CCOCC1,[Pd],CCO,,,,val
US20150284405A1,CC1(C)OC[C@@H]2CCC(=O)N21.C[Si](C)(C)Cl>>CC1(C)OC[C@@H]2CC=C(O[Si](C)(C)C)N21,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20150011533A1,CC(C)(C)OC(=O)N[C@@H]1CCCN(c2c(Br)cnc3[nH]cc(NC(=O)c4cnn(Cc5ccccc5)c4)c23)C1.N#C[Zn]C#N>>CC(C)(C)OC(=O)N[C@@H]1CCCN(c2c(C#N)cnc3[nH]cc(NC(=O)c4cnn(Cc5ccccc5)c4)c23)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20130150343A1,C1CCOC1.C1COCCN1.CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC56CC6)n4c3)c3ccccc32)n(-c2cccc(OCCOS(C)(=O)=O)c2)n1>>CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC56CC6)n4c3)c3ccccc32)n(-c2cccc(OCCN3CCOCC3)c2)n1.O=CO,,C1CCOC1,,,,val
US20040116424A1,CCc1cccc(CC)c1B(O)O.COC(C)c1nc(Br)n(Cl)c1Cl>>CCc1cccc(CC)c1-c1nc(C(C)OC)c(Cl)n1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20150337004A1,COc1ccc(-c2cnc([C@@H]3CCCN3C(=O)[C@]34CC[C@@H](C(C)C)[C@@H]3[C@H]3CC[C@H]5[C@@](C)(CC[C@H]6C(C)(C)[C@@H](OC(C)=O)CC[C@@]65C)[C@]3(C)CC4)[nH]2)cc1>>COc1ccc(-c2cnc([C@@H]3CCCN3C(=O)[C@]34CC[C@@H](C(C)C)[C@@H]3[C@H]3CC[C@H]5[C@@](C)(CC[C@H]6C(C)(C)[C@@H](O)CC[C@@]65C)[C@]3(C)CC4)[nH]2)cc1,,CO,O,C1CCOC1,[Na+].[OH-],val
US04607053,CN(OC1CCCCO1)C(=O)c1ccc(C=CCCc2ccccc2)cc1>>CN(O)C(=O)c1ccc(C=CCCc2ccccc2)cc1,,CCOCC,CO,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20100256357A1,CCOC(=O)c1cc(C)n[nH]1.NS(=O)(=O)c1ccc(Cl)nc1>>CCOC(=O)c1cc(C)n(-c2ccc(S(N)(=O)=O)cn2)n1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US04254229,CC(Cl)CN.c1ccc2scnc2c1>>NCCCSc1ccccc1N,,CO,O,Cl,[Na+].[OH-],val
US03988339,Cl.Clc1cccc2ccncc12>>Cl.Clc1cccc2c1CNCC2,O=[Pt]=O,CO,,,,val
US20070197570A1,CS(=O)(=O)Cl.O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCO[C@](CCO)(c2ccc(Cl)c(Cl)c2)C1>>CS(=O)(=O)OCC[C@@]1(c2ccc(Cl)c(Cl)c2)CN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCO1,,ClCCl,,CCN(CC)CC,O,val
US20070135415A1,CC(C)(C)OC(=O)NC1(C(=O)O)CCc2ccccc21.Nc1cc2c3c(c(-c4ccccc4)[nH]c3c1)C=NNC2=O>>CC(C)(C)OC(=O)NC1(C(=O)Nc2cc3c4c(c(-c5ccccc5)[nH]c4c2)C=NNC3=O)CCc2ccccc21,,CN(C)C=O,ClCCl,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150148340A1,CCOC(=O)c1cn(-c2ccc3c(c2)oc(=O)n3C)c(=O)n(C2CCCc3c(Cl)cccc32)c1=O>>Cn1c(=O)oc2cc(-n3cc(C(=O)O)c(=O)n(C4CCCc5c(Cl)cccc54)c3=O)ccc21,,Cl,,CC(=O)O,,val
US20120165305A1,CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(-c3cnn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)C1>>N#CCC1(n2cc(-c3cnn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CNC1,,C1COCCO1,ClCCl,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20110275611A1,C[C@@H]1COCCN1c1cc(Cl)nc(N)n1.N#Cc1ccc(B(O)O)cc1F>>C[C@@H]1COCCN1c1cc(-c2ccc(C#N)c(F)c2)nc(N)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])O.[Na+],,val
US20060004017A1,COc1cc2c(=O)n(COC(=O)C(C)(C)C)cnc2cc1OCC1CCNCC1>>CC(C)(C)C(=O)OCn1cnc2ccccc2c1=O,,O,,Cl,[Na+].[OH-],val
US05635485,NC(=O)c1ccccn1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>NC(=S)c1ccccn1,,C1CCOC1,,O,,val
US20150190457A1,C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)OC(C)(C)C)[C@H]1CC1(Cl)Cl>>C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1)[C@H]1CC1(Cl)Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150182537A1,CN(CC(Cc1ccc(Cl)c(F)c1)C(=O)O)C(=O)OC(C)(C)C.Cn1nccc1Nc1nccc(-c2cc(F)nc(NN)c2)n1>>CN(CC(Cc1ccc(Cl)c(F)c1)C(=O)NNc1cc(-c2ccnc(Nc3ccnn3C)n2)cc(F)n1)C(=O)OC(C)(C)C,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04620868,C[Si](C)(C)c1cc(C(F)=C(F)C(F)(F)F)c(S(N)(=O)=O)s1>>NS(=O)(=O)c1sccc1C(F)=C(F)C(F)(F)F,,O,,O=S(=O)(O)C(F)(F)F,,val
US20110166146A1,CN1CC[C@@H](O)C1.Fc1ccc(-c2nc3ccc(Cl)cn3c2CNc2nccc(Cl)n2)cc1>>CN1CC[C@@H](Oc2ccnc(NCc3c(-c4ccc(F)cc4)nc4ccc(Cl)cn34)n2)C1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20070244095A1,CCOC(=O)CBr.Cc1cc2c(cc1C(F)(F)F)N(CC1CCNCC1)CCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1>>CCOC(=O)CN1CCC(CN2CCC[C@H](N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnn(C)n3)c3cc(C)c(C(F)(F)F)cc32)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150094297A1,BrP(Br)Br.Cc1sc(C2CCOCC2)nc1CO>>Cc1sc(C2CCOCC2)nc1CBr,,ClCCl,,,,val
US04596870,CC(=O)COc1ccccc1.O=C1CCC(=O)N1Br>>CC(=O)C(Br)Oc1ccccc1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US03931181,CCOC(=O)CC#N.COC(=O)c1c(OC)cc(C=O)cc1OC>>CCOC(=O)C(C#N)=Cc1cc(OC)c(C(=O)OC)c(OC)c1,C1CCNCC1,,,,,val
US20100311747A1,CN(C)C(=O)N1CC2CC(C=O)(CC3CCCCC3)CC2C1.O>>CN(C)C(=O)N1CC2CC(CC3CCCCC3)(C(=O)O)CC2C1,,C1CCOC1,O,CC=C(C)C,[Na+].[O-]Cl,val
US04307033,COC(=O)C(Br)C(C)(C)Br.COC(=O)CC#N>>COC(=O)C1C(C)(C)C1(C#N)C(=O)OC,,CCOCC,CO,O,C[O-].[Na+],val
US20070197478A1,CCOC(=O)N(Cc1ccccc1)c1cc(Cl)nc(N)c1[N+](=O)[O-].Fc1cn[nH]c1>>CCOC(=O)N(Cc1ccccc1)c1cc(-n2cc(F)cn2)nc(N)c1[N+](=O)[O-],,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150093345A1,CCCCCCCCCCCC(=O)O.COc1cc(C[C@H]2C(=O)OC[C@@H]2Cc2ccc(OC)c(OC)c2)ccc1O>>CCCCCCCCCCCC(=O)[O-].COc1cc(C[C@H]2C(=O)OC[C@@H]2Cc2ccc(OC)c(OC)c2)ccc1O,CN(C)c1ccncc1,ClC(Cl)Cl,,O,,val
US20090221655A1,CN.COC(=O)[C@H]1CN(c2ccc3c(C)noc3c2)C(=O)O1>>CNC(=O)[C@H]1CN(c2ccc3c(C)noc3c2)C(=O)O1,,CO,,,,val
US20030032623A1,CC(C)(C#N)C(O)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC(c2ccncc2)C(C)(C)C#N)cc1,,ClCCl,,CCN(CC)CC,,val
US20120208819A1,C[C@H](NC(=O)c1cccnc1N[C@@H](CO)c1ccccc1)c1ccc(F)c(F)c1.O=C(O)c1cc(F)ccc1[N+](=O)[O-]>>C[C@H](NC(=O)c1cccnc1N[C@@H](COc1ccc([N+](=O)[O-])c(C(=O)O)c1)c1ccccc1)c1ccc(F)c(F)c1,,CN(C)C=O,,[H-].[Na+],,val
US04677129,O=C1NC(=O)C2(c3ccc([N+](=O)[O-])cc3)CC1C2>>Nc1ccc(C23CC(C2)C(=O)NC3=O)cc1,[Pd],COCCO,,,,val
US06924373B2,CC(Cl)=Cc1ccc2c(C)cc(=O)oc2c1.CCCC(=O)OC(=O)CCC>>Cc1cc(=O)oc2c(C=CCCl)c(O)ccc12,,ClC(Cl)Cl,,,,val
US20100099695A1,C=CCCCCCOC(=O)N[C@H](C(=O)N1C[C@H](OCC#Cc2ccccc2Br)C[C@H]1C(=O)OC)C(C)(C)C.C=C[Sn](CCCC)(CCCC)CCCC>>C=CCCCCCOC(=O)N[C@H](C(=O)N1C[C@H](OCC#Cc2ccccc2C=C)C[C@H]1C(=O)OC)C(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US03932318,ClP(c1ccccc1)c1ccccc1.Oc1ccccc1>>OP(c1ccccc1)c1ccccc1,,CCOCC,,c1ccncc1,,val
US20100210623A1,CC(C)(C)OC(=O)N1CCC(N)CC1.Clc1cncc(Cl)n1>>CC(C)(C)OC(=O)N1CCC(Nc2cncc(Cl)n2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150232472A1,Cc1nc2ccc(Cl)nn2c1C.Cn1nc(N2CCCC2)nc1CS>>Cc1nc2ccc(SCc3nc(N4CCCC4)nn3C)nn2c1C,,CN(C)C=O,,O,[H-].[Na+],val
US20100210672A1,COC(CCn1cc(-c2sc(C)nc2C)c(=O)[nH]c1=O)OC>>Cc1nc(C)c(-c2cn(CCC=O)c(=O)[nH]c2=O)s1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20080188503A1,Cc1ncc([Sn](C)(C)C)n1C.Fc1cnc(Cl)nc1Cl>>Cc1ncc(-c2nc(Cl)ncc2F)n1C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccco2)c1Br.OC/C=C/c1ccccc1>>Nc1nc(OCC=Cc2ccccc2)c(Br)c(-c2ccco2)n1,,C1COCCO1,,C1CCC2=NCCCN2CC1,,val
US20040053908A1,CC(C)(C)OC(=O)N1CCC(COc2cc3nccc(Oc4ccc(NC(=O)Oc5ccccc5)c(F)c4)c3cc2C#N)CC1.NC1CC1>>CC(C)(C)OC(=O)N1CCC(COc2cc3nccc(Oc4ccc(NC(=O)NC5CC5)c(F)c4)c3cc2C#N)CC1,,C1CCOC1,,,,val
US20140051846A1,COC(CNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21)OC>>O=CCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21,,CO,,Cl,,val
US20060229295A1,CCOC(=O)c1nc(-c2ccc([N+](=O)[O-])cc2)ns1>>Nc1ccc(-c2ncsn2)cc1,,O,,Cl,,val
US20150094297A1,C1COCCN1.COC(=O)c1nc(Br)sc1C>>COC(=O)c1nc(N2CCOCC2)sc1C,,C1CCOC1,,,,val
US04464365,CC(=O)OC(C)=O.CC[C@]12C[C@H](Cl)[C@@H]3[C@H]4CCC(=O)C=C4CC[C@H]3[C@@H]1[C@@H](O)CC2=O>>CC[C@]12C[C@@H](Cl)[C@@H]3[C@H]4CCC(=O)C=C4CC[C@H]3[C@@H]1[C@@H](OC(C)=O)CC2=O,,c1ccncc1,,Cl,,val
US20130210825A1,C=CB1OB(C=C)OB(C=C)O1.CC(C)(C)OC(=O)NC1(c2ccc(-c3nn4c(Br)cnc4cc3-c3ccccc3)cc2)CCC1>>C=Cc1cnc2cc(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)nn12,,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20020013466A1,COC(=O)CBr.COC(=O)Nc1cc(Oc2ccccc2O)c(Cl)cc1F>>COC(=O)COc1ccccc1Oc1cc(NC(=O)OC)c(F)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080275018A1,CC(C)(C)OC(=O)NCCN.CC(C)(C)OC(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)CC(=O)O>>CC(C)(C)OC(=O)NCCNC(=O)C[C@H](CCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20100069355A1,Cc1c2c(cc3c4cc(F)ccc4n(C(=O)OC(C)(C)C)c13)c1cc(F)ccc1n2C(=O)OC(C)(C)C>>Cc1c2[nH]c3ccc(F)cc3c2cc2c1[nH]c1ccc(F)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US04599344,CS(=O)(=O)Cl.ClCCl.Nc1ccc(CC=C2CN3CCC2CC3)cc1>>CS(=O)(=O)Nc1ccc(CC=C2CN3CCC2CC3)cc1.Cl,,ClCCl,,O,[Na+].[OH-],val
US06380249B1,COC(=O)C(=O)CC(=O)c1cc(Cc2ccccc2)ccc1Oc1ccccn1>>O=C(O)C(=O)CC(=O)c1cc(Cc2ccccc2)ccc1Oc1ccccn1,,C1CCOC1,ClC(Cl)Cl,[Na+].[OH-],,val
US20020193367A1,CC(C)(C)OC(=O)Nc1cc(N2CCC2)c(C(F)(F)F)cc1NC(=O)CC(=O)c1cccc(-n2nncc2COC2CCCCO2)c1>>O=C1CC(c2cccc(-n3nncc3CO)c2)=Nc2cc(N3CCC3)c(C(F)(F)F)cc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060161001A1,Cc1cc(N2CCCc3ccc(-c4ccccc4)nc32)nc(N[C@@H](C)Cc2cccc([C@@H](C)NC(=O)OC(C)(C)C)c2)n1>>Cc1cc(N2CCCc3ccc(-c4ccccc4)nc32)nc(N[C@@H](C)Cc2cccc([C@@H](C)N)c2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100222396A1,CC(C)(C)OC(=O)N[C@H](CC#N)Cc1ccccc1.CI>>CN(C(=O)OC(C)(C)C)[C@H](CC#N)Cc1ccccc1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20130216498A1,CC(C)(C)OC(=O)N1CCC[C@@H](N)C1.COc1nc(-c2cnc3ccc(F)cn23)nc(F)c1C(F)(F)F>>COc1nc(-c2cnc3ccc(F)cn23)nc(N[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)c1C(F)(F)F,,CCO,,,,val
US20040121965A1,CC(=O)NCC(=O)O.O=Cc1csc2ccccc12>>CC1=N/C(=C\c2csc3ccccc23)C(=O)O1,,CC(=O)OC(C)=O,,CC(=O)[O-].[Na+],,val
US04732982,CCC(=O)C1(CC)C=CC(=O)NC1.CON>>CCC(=NOC)c1ccc(=O)[nH]c1CC,,CCO,,Cl,c1ccncc1,val
US20110110889A1,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3c(c2)cc(I)n3S(=O)(=O)c2ccccc2)c1F.CNC>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(N(C)C)cc3c2)c1F,,C1COCCO1,O,,,val
US20030008861A1,Br.CCOC(=O)C1(C(=O)OCC)C2CCCC2CN1C(C)=O>>Br.O=C(O)C1NCC2CCCC21,,CC(=O)O,,,,val
US20090221653A1,C[C@@H](CNC(=O)CSCCC(=O)O)c1ccccc1>>C[C@@H](CNCCSCCCO)c1ccccc1,,C1CCOC1,,,,val
US20130029995A1,CC1CCN(c2nc(C(F)(F)F)ccc2CN)CC1.O=C(Nc1nccc2ccccc12)Oc1ccccc1>>CC1CCN(c2nc(C(F)(F)F)ccc2CNC(=O)Nc2nccc3ccccc23)CC1,,CS(C)=O,O,CCN(CC)CC,,val
US05773663,COc1ccc(C(=O)c2c(Cl)cccc2Cl)c(C)c1.O=[N+]([O-])O>>COc1cc(C)c(C(=O)c2c(Cl)cccc2Cl)cc1[N+](=O)[O-],,O,,,,val
US20120059019A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)c(OC)cc3C)c(F)c12.NC1(c2ccc3cnccc3n2)CC1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5ccc6cnccc6n5)CC4)c(OC)cc3C)c(F)c12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140275172A1,CCOC(=O)CCc1ccc(O)c(C)c1C.CCc1cc2cc3c(c(CCl)c2o1)CC(C)(C)O3>>CCOC(=O)CCc1ccc(OCc2c3c(cc4cc(CC)oc24)OC(C)(C)C3)c(C)c1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050038031A1,O=[N+]([O-])O.Oc1c(F)cccc1Cl>>O=[N+]([O-])c1cc(F)c(O)c(Cl)c1,,CC(=O)O,,,,val
US20150065724A1,C#CC1=NO[C@H]([C@@H](CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)OC[C@H](COCc2ccccc2)OS(=O)(=O)c2ccc(C)cc2)C1>>C#CC1=NO[C@H]([C@@H](CO)OC[C@H](COCc2ccccc2)OS(=O)(=O)c2ccc(C)cc2)C1,,C1CCOC1,,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20040110804A1,C=O.CN.COC(=O)C(O)=CC(=O)N(C)Cc1ccc(Cl)c(Cl)c1>>CN1CC(C(=O)N(C)Cc2ccc(Cl)c(Cl)c2)=C(O)C1=O,,CCO,,C1CCOC1,,val
US20080185577A1,CCCCCCCCc1ccc(I)cc1.COB(OC)OC>>CCCCCCCCc1ccc(B(O)O)cc1,,C1CCOC1,O,Cl,[Li]CCCC,val
US04521422,CCOC=CC(=O)c1cccnc1.Nc1n[nH]cc1C(=O)c1ccccc1>>O=C(c1ccccc1)c1cnn2c(-c3cccnc3)ccnc12,,Cc1ccccc1C,,,,val
US20070293690A1,CC(=O)Cc1ccc(O)c(Br)c1.COCOC>>COCOc1ccc(CC(C)=O)cc1Br,,Cc1ccccc1,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20160002224A1,C[Si](C)(C)CCOCn1c(Cl)cc2nc(-c3ccc(C4(CO)CC4)cc3)c(Cl)cc21.II>>C[Si](C)(C)CCOCn1c(Cl)cc2nc(-c3ccc(C4(CI)CC4)cc3)c(Cl)cc21,,C1CCOC1,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160221946A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCc1cn(S(=O)(=O)c2cccc(F)c2)c2nc(Br)ccc12>>CN(Cc1cn(S(=O)(=O)c2cccc(F)c2)c2nc(Br)ccc12)C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,O,val
US20130005716A1,COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2c1OC1(CCCC1)O2.O=C(OO)c1cccc(Cl)c1>>COc1ccc(C(=O)Cc2c(Cl)c[n+]([O-])cc2Cl)c2c1OC1(CCCC1)O2,,CCOC(C)=O,,,,val
US20080312234A1,O=C(OCc1ccccc1)[C@@H]1CCCN1>>O=C(OCc1ccccc1)C1CCCN1,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20100249110A1,CCOC(=O)C1CN(Cc2ccccc2)c2nc(SC)nc(Cl)c2C1=O.NN>>CCOC(=O)C1CN(Cc2ccccc2)c2nc(SC)nc(NN)c2C1=O,,C1COCCO1,,CCN(CC)CC,O,val
US20120149691A1,C[C@H]1CCCC[C@H]1N.N#Cc1cnn2cc([N+](=O)[O-])cc2c1Cl>>C[C@H]1CCCC[C@H]1Nc1c(C#N)cnn2cc([N+](=O)[O-])cc12,,CCOC(C)=O,CN(C)C=O,Cl,,val
US05821247,CN(C)C=O.Cn1c(=O)cc(N)n(-c2ccccc2)c1=O>>Cn1c(=O)c(C=O)c(N)n(-c2ccccc2)c1=O,,O,,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US20090093456A1,COc1cc(NC(=O)c2sc(-c3ccc(Cl)cc3)cc2C#C[Si](C)(C)C)ccc1OC1CN(C(=O)OC(C)(C)C)C1>>COc1cc(-n2ccc3cc(-c4ccc(Cl)cc4)sc3c2=O)ccc1OC1CN(C(=O)OC(C)(C)C)C1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050026964A1,Cn1cc(C(=O)O)c(Nc2ccc(I)cc2F)cc1=O.NC(CO)(CO)CO>>Cn1cc(C(=O)OCC(N)(CO)CO)c(Nc2ccc(I)cc2F)cc1=O,,C1CCOC1,CN(C)C=O,O=C(n1ccnc1)n1ccnc1,,val
US06046201,CC(C)Br.O=C(NCCCCCCCCCCCCO)c1ccc(N2CCNCC2)nc1>>CC(C)N1CCN(c2ccc(C(=O)NCCCCCCCCCCCCO)cn2)CC1,,CN(C)C=O,ClC(Cl)Cl,O=C([O-])[O-].[K+].[K+],,val
US20100210704A1,Cc1cc(F)c(-n2nc(O)cc2C)cc1SCC(F)(F)F.O=S(=O)(OCC(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>Cc1cc(F)c(-n2nc(OCC(F)(F)C(F)(F)F)cc2C)cc1SCC(F)(F)F,,CCOC(C)=O,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US04552866,C[C@@H](C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C)N(CC(O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1.Cl>>C[C@H](NCC(O)C(Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C.Cl,[Pd],CO,,,,val
US20120253035A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cn1nccc1-c1ccc(F)c([C@@]2(C)NC(=O)COC(C)(C)C2(F)F)c1>>Cn1nccc1-c1ccc(F)c([C@@]2(C)NC(=S)COC(C)(C)C2(F)F)c1,,C1COCCO1,,,,val
US05252593,CCCCc1nn(CC(F)(F)F)c(COC)c1Cc1ccc2oc(-c3ccccc3-c3nnn(C(c4ccccc4)(c4ccccc4)c4ccccc4)n3)c(Br)c2c1>>CCCCc1nn(CC(F)(F)F)c(COC)c1Cc1ccc2oc(-c3ccccc3-c3nnn[nH]3)c(Br)c2c1,,CO,ClCCl,,,val
US20140155389A1,COc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1nc(Nc2ccc(Cl)c(Cl)c2Cl)cc2cn[nH]c(=O)c12>>COc1cc(N2CCNCC2)ccc1Nc1nc(Nc2ccc(Cl)c(Cl)c2Cl)cc2cn[nH]c(=O)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060194802A1,N#CC(C(N)=O)C(=S)Nc1ccc(Oc2cc(Cl)ccc2Cl)c(F)c1>>N#Cc1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)c(F)c1,,CCOC(C)=O,,BrBr,,val
US20070232642A1,CN(C(=O)CCC(C#N)Cc1cc(Oc2ccccc2)ccc1N)C1CCCCC1>>CN(C(=O)CCC1Cc2cc(Oc3ccccc3)ccc2N=C1N)C1CCCCC1,,Cc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20020183364A1,CC(C)(C)OC(=O)Nc1ccc2c(c1)CC(=O)N2.O=Cc1cc2ccccc2[nH]1>>CC(C)(C)OC(=O)Nc1ccc2c(c1)C(=Cc1cc3ccccc3[nH]1)C(=O)N2,C1CCNCC1,CCO,,,,val
US05962457,Cc1ccccc1N.Cc1nc2cnccc2c(=O)o1>>Cc1ccccc1-n1c(C)nc2cnccc2c1=O,,CC(=O)O,,,,val
US20040152740A1,CC(C)(C)OC(=O)NC(C(=O)O)c1ccccc1.CC(C)c1ccc(N)cc1>>CC(C)c1ccc(NC(=O)C(NC(=O)OC(C)(C)C)c2ccccc2)cc1,,C1CCOC1,ClCCl,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20150291563A1,COC(=O)C(=O)C=Cc1ccc(Br)s1.NNc1ccccc1Cl>>COC(=O)C1=NN(c2ccccc2Cl)C(c2ccc(Br)s2)C1,,CC(=O)O,,Cl,,val
US06300316B1,CI.COc1ccccc1C1CC(O)CCN1C(=O)OC(C)(C)C>>COc1ccccc1C1CC(OC)CCN1C(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US04914204,Fc1c(F)c(F)c(OC2CCNCC2)c(F)c1F.Fc1ccc(C(CCCCl)c2ccc(F)cc2)cc1>>Fc1ccc(C(CCCN2CCC(Oc3c(F)c(F)c(F)c(F)c3F)CC2)c2ccc(F)cc2)cc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US05686486,CCCCC(O)c1ccccc1.O=c1cc(O)c2ccccc2o1>>CCCCC(c1ccccc1)c1c(O)c2ccccc2oc1=O,,C1COCCO1,,CCOCC,FB(F)F,val
US20100286225A1,COC(=O)c1cccc(CN(C(=O)OC(C)(C)C)S(=O)(=O)c2cc(C(=O)NN3c4ccccc4CC3C)ccc2Cl)c1>>CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(S(=O)(=O)N(Cc2cccc(C(=O)O)c2)C(=O)OC(C)(C)C)c1,,CC#N,O,[Li+].[OH-],,val
US20130190377A1,C=CC(=O)OC1(C)C(c2ccccc2)CC(=O)N1C(=O)C=C>>C=CC(=O)N1C(=C)C(c2ccccc2)CC1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090105352A1,O=C(Cl)COCc1ccccc1.Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl>>O=C(COCc1ccccc1)Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl,,CC(C)=O,,CCN(CC)CC,,val
US20090105253A1,O=C(NCCCl)NCCNC(=O)c1nnn(-c2ccc(C(=O)NCC(F)(F)F)cc2)c1CCCCCF>>O=C(NCC(F)(F)F)c1ccc(-n2nnc(C(=O)NCCN3CCNC3=O)c2CCCCCF)cc1,,C1CCOC1,,Cl,CC(C)(C)[O-].[K+],val
US20070054896A1,C=O.O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(OC3CCNC3)cc12>>CN1CCC(Oc2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1,,CC#N,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20050267095A1,CSc1ccc(C2(C#N)CCOCC2)cc1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ccc(C2(C#N)CCOCC2)cc1,,ClCCl,,,,val
US20100331306A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.O=C1c2ccccc2C(=O)N1Cc1nc2c(F)cccc2cc1Br>>O=C1c2ccccc2C(=O)N1Cc1nc2c(F)cccc2cc1-c1ccccn1,,C1COCCO1,ClCCl,,,val
US20160166560A1,COc1ccc(CN2CCC(N(C)C(=O)n3cnc(-c4cccc(NC(N)=O)c4)c3)CC2)cc1OC.Cl>>COc1ccc(CN2CCC(N(C)C(=O)n3cnc(-c4cccc(NC(N)=O)c4)c3)CC2)cc1OC.Cl,,CCOC(C)=O,,CCOCC,,val
US04788206,CCCCCCCCCCCC/C(=C\C=C\C(=O)O)c1ccc(OC)cc1.O=[N+]([O-])c1ccc(O)cc1>>CCCCC/C(=C\C=C\C(=O)Oc1ccc([N+](=O)[O-])cc1)c1ccc(OC)cc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20050171174A1,N#Cc1ccc(C[C@@]23C[C@H](N)CN2C(=O)N(c2cc(Cl)cc(Cl)c2)C3=O)cc1.NC(=O)CCC(=O)O>>N#Cc1ccc(C[C@@]23C[C@H](NC(=O)CCC(N)=O)CN2C(=O)N(c2cc(Cl)cc(Cl)c2)C3=O)cc1,,C1CCOC1,ClCCCl,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US20150291509A1,CCCCC(=O)Cl.COC(=O)c1ccccc1-c1ccc(CNc2ccccc2)cc1>>CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)OC)cc1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US06403610B1,COC(=O)[C@H]1CN(CC#Cc2cccs2)CC[C@H]1CCC(=O)c1ccnc2ccc(OC)cc12>>COC(=O)[C@H]1CN(CC#Cc2cccs2)CC[C@H]1CCC(O)c1ccnc2ccc(OC)cc12,,CO,O,[BH4-].[Na+],,val
US20150141400A1,CC(C)(C)OC(=O)N[C@H]1CCCN(C(=O)OCc2ccccc2)C1.CC(C)(C)[Si](C)(C)OCCBr>>CC(C)(C)OC(=O)N(CCO[Si](C)(C)C(C)(C)C)[C@H]1CCCN(C(=O)OCc2ccccc2)C1,,CN(C)C=O,,O,[H-].[Na+],val
US20150087646A1,CC(C)C(N)=NO.COC(=O)c1ccc(-n2nc(-c3c(Cl)cccc3Cl)[nH]c2=O)cc1OC>>COc1cc(-n2nc(-c3c(Cl)cccc3Cl)[nH]c2=O)ccc1-c1nc(C(C)C)no1,,C1CCOC1,,[H-].[Na+],,val
US05741926,N#CCc1ccc(NC(=O)CBr)cc1.Nc1ccccc1F>>N#CCc1ccc(NC(=O)CNc2ccccc2F)cc1,,CN(C)C=O,,,,val
US20140094495A1,CC1(CO)CCC(=O)N1.O=S(Cl)Cl>>CC1(CCl)CCC(=O)N1,,ClCCCl,,c1ccncc1,,val
US20100305096A1,CN(C)C(=O)C1CNC1.Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1>>Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CC(C(=O)N(C)C)C3)n(C)c2n1,,ClCCCl,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20090270374A1,O=C1COC2=CN=C(/C=C/c3ccccc3)NC2=N1.O=[Os](=O)(=O)=O>>O=CC1=NC=C2OCC(=O)N=C2N1,O=[Os](=O)(=O)=O,ClCCl,O,C1COCCO1,,val
US20150191478A1,CCOC(OCC)c1cc2cncc(-c3cccc(CN4CCOCC4)c3)c2o1>>O=Cc1cc2cncc(-c3cccc(CN4CCOCC4)c3)c2o1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20030225107A1,CC1(C2(c3ccc([C@]4(CO)CNC(=O)O4)cc3)CC2)OCCO1.O=S(=O)(Cl)c1ccccc1>>CC1(C2(c3ccc([C@]4(COS(=O)(=O)c5ccccc5)CNC(=O)O4)cc3)CC2)OCCO1,,C1CCOC1,,CCN(CC)CC,,val
US06673937B2,COc1ccc(O)c2c1C1(CCC2)OCCO1.COc1cccc2cccc(I)c12>>c1ccc2c(Oc3cccc4ccccc34)cccc2c1,,c1ccncc1,,O=C([O-])[O-].[K+].[K+],,val
US20130267493A1,COc1cc(I)ccc1Br.O=C1CCC1>>COc1cc(C2(O)CCC2)ccc1Br,,C1CCOC1,,[Li]CCCC,,val
US20060084663A1,COC(=O)CCc1ccc(OCCc2nc(-c3ccc(-c4ccccn4)cc3)oc2C)cc1C>>Cc1cc(OCCc2nc(-c3ccc(-c4ccccn4)cc3)oc2C)ccc1CCC(=O)O,,C1CCOC1,CCOC(C)=O,Cl,[Na+].[OH-],val
US20140099695A1,C#CCN(C)Cc1c(O)c(Br)cc2c(CO)cc(=O)oc12.CC(C)(C)OC(=O)CCOC(=O)Oc1ccc([N+](=O)[O-])cc1>>C#CCN(C)Cc1c(O)c(Br)cc2c(COC(=O)OCCC(=O)OC(C)(C)C)cc(=O)oc12,CN(C)c1ccncc1,ClCCl,,,,val
US20150284321A1,Nc1ccccc1NS(=O)(=O)c1ccccc1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1ccccc1NS(=O)(=O)c1ccccc1,,CCOC(C)=O,,,,val
US04216218,CCOC(=O)N1CC[C@@H](Oc2ccc(F)cc2)[C@H](c2ccccc2)C1.O=C(O)/C=C/C(=O)O>>Fc1ccc(O[C@@H]2CCNC[C@H]2c2ccccc2)cc1.O=C(O)/C=C/C(=O)O,,CCO,CCOCC,[Na+].[OH-],,val
US20050187387A1,CC(=O)c1cc(F)c(Cl)cc1O.CCOC(=O)C(=O)OCC>>O=C(O)c1cc(=O)c2cc(F)c(Cl)cc2o1,,CCOCC,,C,C[O-].[Na+],val
US20050277645A1,O=C(O)CC1Cc2cc(F)ccc2C1=O>>OCCC1Cc2cc(F)ccc2C1O,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06071927,CI.Oc1ccc(OCC(F)(F)F)cc1Br>>COc1ccc(OCC(F)(F)F)cc1Br,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150315198A1,Cc1ccc2c(=O)n3c(nc2c1)CCC3.O=C1CCC(=O)N1Br>>O=c1c2ccc(CBr)cc2nc2n1CCC2,,ClC(Cl)(Cl)Cl,,,,val
US20070032485A1,CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(S(=O)(=O)CCC(=O)OC)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC.OO>>CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(S(=O)(=O)O)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC,,CCO,ClC(Cl)Cl,Cl,[Na+].[OH-],val
US06172228B2,CN(C)S(=O)(=O)CCCCCCCl.Clc1ccc(C(c2ccccc2)N2CCNCC2)cc1>>CN(C)S(=O)(=O)CCCCCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1,,CCN(C(C)C)C(C)C,,,,val
US20060035956A1,CCOC(=O)CBr.O=C(Cc1ccc2cc[nH]c2c1)NCC#Cc1ccc(C(F)(F)F)cc1>>CCOC(=O)Cn1ccc2ccc(CC(=O)NCC#Cc3ccc(C(F)(F)F)cc3)cc21,,CC#N,,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20030036655A1,CNC.O=[N+]([O-])c1ccc(Cc2ccc(S(=O)(=O)Cl)cc2)cc1>>CN(C)S(=O)(=O)c1ccc(Cc2ccc([N+](=O)[O-])cc2)cc1,,C1CCOC1,,ClCCl,,val
US20020147191A1,CC(=O)Nc1ccccc1Oc1ccccc1.ClCc1ccccc1Cl>>CC(=O)N(Cc1ccccc1Cl)c1ccccc1Oc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20030236256A1,Clc1cccc(Nc2nccc(-c3ccnc(Cl)c3)n2)c1.N>>Nc1cc(-c2ccnc(Nc3cccc(Cl)c3)n2)ccn1,,C1COCCO1,,,,val
US20160108039A1,CC(C)(C)[Si](C)(C)Cl.CC1OCC(C)(CO)N(Cc2ccccc2)C1=O>>CC1OCC(C)(CO[Si](C)(C)C(C)(C)C)N(Cc2ccccc2)C1=O,,CN(C)C=O,,c1c[nH]cn1,,val
US20160237069A1,CN.Cc1cc(NCCCN(C)C)nc(NC(=S)Nc2ccc(Cl)c(Cl)c2)n1>>CN=C(Nc1ccc(Cl)c(Cl)c1)Nc1nc(C)cc(NCCCN(C)C)n1,,CN(C)C=O,,CCN(CC)CC,C[n+]1ccccc1Cl.[I-],val
US20080287438A1,CCN=C=NCCCN(C)C.Cn1ncc(/C=C/C(=O)Nc2ccc(Cc3nc(C(=O)O)cs3)cc2)c1-c1ccc(F)cc1>>Cn1ncc(/C=C/C(=O)Nc2ccc(Cc3nc(C(N)=O)cs3)cc2)c1-c1ccc(F)cc1,,O,,CN(C)C=O,Cl,val
US20070112033A1,CCOC(=O)c1cccc2c1ncn2CCC(C)(C)NCC(O)c1cccc(NS(=O)(=O)c2ccccc2)c1.O=C(O)C(F)(F)F>>CC(C)(CCn1cnc2c(C(=O)O)cccc21)NCC(O)c1cccc(NS(=O)(=O)c2ccccc2)c1.O=C(O)C(F)(F)F,,CCO,,[Li+].[OH-],,val
US20120232056A1,COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(Cl)nc2c1.NC1CCC1>>COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(NC3CCC3)nc2c1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US04354973,N#CC=Cc1ccc(Cl)cc1C(=O)c1ccccc1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>N#Cc1c[nH]cc1-c1ccc(Cl)cc1C(=O)c1ccccc1,,CCOCC,O,CS(C)=O,[H-].[Na+],val
US20080214533A1,CC(C)(C)[Si](C)(C)OCCNc1ccc(NC(=O)c2nccnc2C(=O)Nc2ccc(Cl)cn2)cc1.N#CBr>>CC(C)(C)[Si](C)(C)OCCN(C#N)c1ccc(NC(=O)c2nccnc2C(=O)Nc2ccc(Cl)cn2)cc1,,ClCCl,O,C1CCOC1,O=C([O-])O.[Na+],val
US20150274753A1,CC(C)(CNC(=O)OC(C)(C)C)CNC(=O)c1ccc(Nc2nc(NCc3ccc(OCCCBr)c(Cl)c3)nc(OCC(F)(F)F)n2)cc1.O=C(O)C(F)(F)F>>CC(C)(CN)CNC(=O)c1ccc(Nc2nc(NCc3ccc(OCCCBr)c(Cl)c3)nc(OCC(F)(F)F)n2)cc1.O=C(O)C(F)(F)F,,CCOC(C)=O,,ClCCl,,val
US20120040962A1,OCC1c2ccc(Br)cc2Oc2ccc(Br)cc21>>Brc1ccc2c(c1)C=Cc1ccc(Br)cc1O2,,Cc1ccccc1,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20160068709A1,Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1C.O=Cc1ccc(C=O)cc1.Oc1ccc(Cc2ccccc2)cc1>>Cc1ccc(C=O)c(-c2cc(Cc3ccccc3)ccc2O)c1-c1cc(Cc2ccccc2)ccc1O,,Cc1ccccc1C,,O,,val
US20040224997A1,COC(=O)C1CCCC1C(=O)c1ccc(-c2ccc(NC=O)c(F)c2)cc1>>COC(=O)C1CCCC1C(=O)c1ccc(-c2ccc(N)c(F)c2)cc1,,CO,,Cl,,val
US20130137865A1,CCOC(=O)c1cnn(C)c1COc1ccc(Cl)cc1.N=C(NO)c1cccc(S(N)(=O)=O)c1>>Cn1ncc(-c2nc(-c3cccc(S(N)(=O)=O)c3)no2)c1COc1ccc(Cl)cc1,,CCO,,C[O-].[Na+],,val
US20050143422A1,COC(=O)[C@@H](NS(=O)(=O)c1ccc(-c2ccc(NC(=O)c3oc4cccc(-c5ccncc5)c4c3C)cc2)cc1)C(C)C>>Cc1c(C(=O)Nc2ccc(-c3ccc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)cc3)cc2)oc2cccc(-c3ccncc3)c12,,C1CCOC1,,[Li+].[OH-],,val
US04128588,C#Cc1ccccc1.O=[N+]([O-])c1ccccc1Br>>O=[N+]([O-])c1cccc(C#Cc2ccccc2)c1,[Cu]I,,,,,val
US04772600,CCCNCCC.C[C@H](C(=O)O)n1c(-c2ccc(Cl)cc2)nc2cccnc21>>CCCN(CCC)C(=O)[C@@H](C)n1c(-c2ccc(Cl)cc2)nc2cccnc21,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20090029994A1,CCOC(=O)CCCOc1cnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)cc(Br)c2O)nc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)CCCOc1cnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)cc(Br)c2OS(=O)(=O)C(F)(F)F)nc1,,ClC(Cl)Cl,ClCCl,c1ccncc1,O=C([O-])O.[Na+],val
US04196300,CCCCCCCCCCCCC(C)C1(C(=O)O)CO1.NCCO>>CCCCCCCCCCCCC(C)C1(C(=O)NCCO)CO1,,C1CCOC1,,CCN(CC)CC,CCOC(=O)Cl,val
US20040133008A1,Cc1cccc(-n2c(C)ccc2C)n1.O=C=O>>Cc1ccc(C)n1-c1cccc(CC(=O)O)n1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20070254935A1,CI.Cc1c(C(O)CN(Cc2ccccc2)C(C)C)nn(-c2ccccc2Cl)c1-c1ccc(Cl)cc1>>COC(CN(Cc1ccccc1)C(C)C)c1nn(-c2ccccc2Cl)c(-c2ccc(Cl)cc2)c1C,,CN(C)C=O,,[H-].[Na+],,val
US04663319,O=C1CCN(Cc2ccc([N+](=O)[O-])cc2)C(=O)C1=C1SC=CS1>>Nc1ccc(CN2CCC(=O)C(=C3SC=CS3)C2=O)cc1,[Pd],CCO,,,,val
US20040142986A1,CC(C)(C)OC(=O)C[C@@H](CCCC1CCCCC1)c1nc(CN)no1.COC(=O)CBr>>COC(=O)CNCc1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1,,C1CCOC1,CCOC(C)=O,CN1CCOCC1,,val
US20060035909A1,Clc1nc(Cl)c2[nH]nnc2n1.NCc1ccccc1>>Clc1nc(NCc2ccccc2)c2[nH]nnc2n1,,CCCCO,,,,val
US20100292212A1,CCOC(=O)C1(CCOC)CCNCC1.O=S(=O)(Cl)N1CCOCC1>>CCOC(=O)C1(CCOC)CCN(S(=O)(=O)N2CCOCC2)CC1,CN(C)c1ccncc1,ClCCl,,,,val
US20120108582A1,C[C@H](c1ccccc1)N1C[C@]2(C(=O)OC(C)(C)C)COC(O)C2C1=O>>C[C@H](c1ccccc1)N1C[C@@](CO)(C(=O)OC(C)(C)C)C(CO)C1=O,,C1CCOC1,CCO,[BH4-].[Na+],,val
US07037929B1,NS(=O)(=O)c1ccc(C(=O)O)cc1.Nc1ncc(Br)s1>>NS(=O)(=O)c1ccc(C(=O)Nc2ncc(Br)s2)cc1,,C1CCOC1,CN(C)C=O,Br,CCN(CC)CC,val
US20100063107A1,CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3cccc(CO)c3)c(F)c2)ccn1.O=S(=O)(O)O>>CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3cccc(CO)c3)c(F)c2)ccn1.O=S(=O)(O)O,,CC(C)=O,CCOC(C)=O,,,val
US20100179143A1,Brc1c[nH]nc1-c1ccccc1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)n2cc(Br)c(-c3ccccc3)n2)cc1,,ClCCl,,c1ccncc1,,val
US20150119405A1,COc1cc(OC)cc(B(O)O)c1.Clc1ncc2cc(Br)cc(Cl)c2n1>>COc1cc(OC)cc(-c2cc(Cl)c3nc(Cl)ncc3c2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04602002,NCC(O)CC[C@H](N)C(=O)O.O=C(OCc1ccccc1)ON1C(=O)C2C3C=CC(C3)C2C1=O>>NCC(O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)O,,CC#N,O,Cl,O=C([O-])O.[Na+],val
US20090239845A1,CC(C)(C)OC(O)N1CCC(CO)CC1.Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCC(C)C.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cc1cc(NC(=O)OCC2CCN(C(=O)OC(C)(C)C)CC2)nn1Cc1cc(Cl)ccc1OCC(C)C,,Cc1ccccc1,,CCOC(C)=O,,val
US20070265248A1,COC(=O)c1ccccc1N1CCN(Cc2ccccc2)CC1>>O=C(O)c1ccccc1N1CCN(Cc2ccccc2)CC1,,C1CCOC1,O,[Li+].[OH-],,val
US20090221663A1,CCCSc1c(C(=O)O)cnn1-c1ccc(CC(=O)OC)cc1.NC1CCCCC1>>CCCSc1c(C(=O)NC2CCCCC2)cnn1-c1ccc(CC(=O)OC)cc1,CN(C)C=O,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20040242572A1,N#CCc1ccc(CN2CCCC2)cc1>>NCCc1ccc(CN2CCCC2)cc1,[Ni],N,,[H][H],,val
US20100137587A1,BrCCc1ccccc1.COC(=O)c1cc2ccccc2[nH]1>>COC(=O)c1cc2ccccc2n1CCc1ccccc1,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070066820A1,CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccc(OCc2ccc(Cl)cc2Cl)cc1.Cl>>Cl.Clc1ccc(COc2ccc(OC[C@H]3CCCN3)cc2)c(Cl)c1,,CO,,CCOCC,,val
US05155100,CCN(CC)C(=O)CCl.O=C(O)CCNC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NCP(=O)(Oc1ccccc1)Oc1ccccc1>>CCN(CC)C(=O)COC(=O)CCNC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NCP(=O)(Oc1ccccc1)Oc1ccccc1,,CCOC(C)=O,,CCN(CC)CC,[I-].[Na+],val
US05026401,CC(=O)Nc1cc(N)ccc1OCC(C)O.Cl.Cl>>CC(O)COc1ccc(N)cc1N.Cl.Cl,,CCO,,,,val
US20100323994A1,Nc1cc(Cl)cc(N)n1.O=C(Nc1ccncc1F)c1cnc2c(Br)cc(Cl)nn12>>Nc1cc(Cl)cc(Nc2cc(Cl)nn3c(C(=O)Nc4ccncc4F)cnc23)n1,,C1CCOC1,O,CN(C)C=O,[H-].[Na+],val
US20120135939A1,C1COCCN1.Cc1ccc(S(=O)(=O)SCCCCl)cc1>>Cc1ccc(S(=O)(=O)SCCCN2CCOCC2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080255086A1,CC(=NNC(N)=O)C(C)(C)C.CN(C)C=O>>CC(C)(C)c1n[nH]cc1C=O,,CCOCC,O,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US05021421,CCCBr.Fc1ccc(-c2cc(N3CCNCC3)nc3c2CCCCCC3)cc1>>CCCN1CCN(c2cc(-c3ccc(F)cc3)c3c(n2)CCCCCC3)CC1,,CO,,[I-].[K+],,val
US20110230497A1,CCOC(=O)C[C@H]1CCN2C(=O)OC[C@H]2C1>>O=C(O)C[C@H]1CCN2C(=O)OC[C@H]2C1,O,CO,,[Li+].[OH-],,val
US20050137243A1,NC1CCCC1.O=CCn1ncc2ccc(NC(=O)Cc3ccc(Oc4ccccc4)cc3)cc21>>O=C(Cc1ccc(Oc2ccccc2)cc1)Nc1ccc2cnn(CCNC3CCCC3)c2c1,,C1CCOC1,CCOC(C)=O,[BH3-]C#N.[Na+],,val
US20080085890A1,CN1CCN(c2ncc([N+](=O)[O-])cn2)CC1>>CN1CCN(c2ncc(N)cn2)CC1,[Fe],CO,,CC(=O)O,,val
US20070299186A1,F[B-](F)(F)F.Nc1ccc(Oc2ccccc2)cc1.c1ccc(-c2cc(-c3ccccc3)[o+]c(-c3ccccc3)c2)cc1>>F[B-](F)(F)F.c1ccc(Oc2ccc(-[n+]3c(-c4ccccc4)cc(-c4ccccc4)cc3-c3ccccc3)cc2)cc1,,CCO,,,,val
US20070270467A1,CC(C)Br.OC1(c2cccc(C(F)(F)F)c2F)CCNCC1>>CC(C)N1CCC(O)(c2cccc(C(F)(F)F)c2F)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040147748A1,CC[Si](Cl)(CC)CC.O=[N+]([O-])c1cnc(NCCO)cn1>>CC[Si](CC)(CC)OCCNc1cnc([N+](=O)[O-])cn1,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20130096121A1,CC(C)CI.COC(=O)C1CCCCC1>>CC(C)CC1(CO)CCCCC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20080262050A1,COC(=O)CBr.COc1cc2cc(N)c(OCc3ccccc3)cc2oc1=O>>COC(=O)CNc1cc2cc(OC)c(=O)oc2cc1OCc1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110111046A1,CC(=O)N(C)C.COC(=O)c1ccnc(C(C)=O)c1>>COC(=O)c1ccnc(C(=O)/C=C\N(C)C)c1,,Cc1ccccc1,,CN(C)C=O,,val
US20120252815A1,CC(=O)OCCCCBr.CC1(C)CCC(C)(C)c2cc(-c3csc(N4CCC(N)CC4)n3)ccc21>>CC1(C)CCC(C)(C)c2cc(-c3csc(N4CCC(NCCCCO)CC4)n3)ccc21,,CO,,Cl,[Na+].[OH-],val
US20110009394A1,Cl.Cl.NC1CCN(CC2CCn3c(=O)cnc4ccc(=O)n2c43)CC1.O=Cc1cc2c(cn1)OCS2>>Cl.Cl.O=c1cnc2ccc(=O)n3c2n1CCC3CN1CCC(NCc2cc3c(cn2)OCS3)CC1,,CO,,CC(=O)O,CC(=O)[O-].[Na+],val
US20140080808A1,CC(C)(C)[Si](C)(C)OC[C@@]1(C)CC(=S)NCCS1.CI>>CSC1=NCCS[C@@](C)(CO[Si](C)(C)C(C)(C)C)C1,,C1CCOC1,,O,[K+].[OH-],val
US20100311966A1,COC(=O)[C@@H](NC(=O)c1ccc([N+](=O)[O-])c(OC)c1)[C@@H](C)O>>COC(=O)C1N=C(c2ccc([N+](=O)[O-])c(OC)c2)OC1C,,C1CCOC1,,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US04168248,CC(=O)O.CCCCCCC(C)=CCO>>CCCCCCC(C)=CCOC(C)=O,,CC(=O)O,Cc1ccccc1,CC(=O)OC(C)=O,,val
US20060089394A1,CCCCC(Oc1ccc(OCC(=O)OCC)c(C)c1)c1cccc(Br)c1.OB(O)c1ccc(C(F)(F)F)cc1>>CCCCC(Oc1ccc(OCC(=O)OCC)c(C)c1)c1cccc(-c2ccc(C(F)(F)F)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US04864052,CC(C)=CC1C(C(=O)OC(C#N)c2cccc(Oc3ccccc3)c2)C1(C)C.O=[O+][O-]>>CC1(C)C(C=O)C1C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1,,CCOC(C)=O,,,,val
US20090023740A1,COc1ccc(CNc2ccc(S(=O)(=O)Nc3nccs3)c(F)c2)c(OC)c1>>Nc1ccc(S(=O)(=O)Nc2nccs2)c(F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040209892A1,O=[N+]([O-])O.Oc1ccc(Oc2ccnc3[nH]ccc23)cc1>>O=[N+]([O-])c1cc(Oc2ccnc3[nH]ccc23)ccc1O,,CC(=O)O,,,,val
US20090312308A1,N#Cc1cc([N+](=O)[O-])ccc1Cl.[Cl-].[NH4+]>>Cl.N=C(N)c1cc([N+](=O)[O-])ccc1Cl,,CO,,C[O-].[Na+],,val
US04946942,C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O>>C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O,[Pd],CCO,,,,val
US04110342,COC(=O)Cc1ccc(CN=[N+]=[N-])s1>>[N-]=[N+]=NCc1ccc(CC(=O)O)s1,,C1CCOC1,,Cl,,val
US20070072912A1,N.Nc1c(C(=O)O)cccc1[N+](=O)[O-]>>NC(=O)c1cccc([N+](=O)[O-])c1N,,C1CCOC1,,,,val
US20130059834A1,CC(NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)[C@@H]1C[C@H](O)C1>>CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)[C@H]1C[C@H](O)C1,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US20090105253A1,CCOC(=O)c1cn(-c2ccc(C(=O)OC)cc2OCC)nn1>>CCOc1cc(C(=O)O)ccc1-n1cc(C(=O)O)nn1,,CCO,,O,[Na+].[OH-],val
US20150299218A1,COc1ccc(F)c(C=O)c1.OCCc1c[nH]c2ccccc12>>COc1ccc(F)c(C2OCCc3c2[nH]c2ccccc32)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100240653A1,CS(=O)(=O)OCCc1ccc(-c2ccccc2)cc1.C[C@@H]1CCCN1>>C[C@@H]1CCCN1CCc1ccc(-c2ccccc2)cc1,,CC#N,CCOC(C)=O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US05281593,Cc1ccc2ccc(Cl)cc2n1.O=C1CCC(=O)N1Cl>>ClCc1ccc2ccc(Cl)cc2n1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20110306607A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.Clc1ncccc1-n1cccn1>>CC(C)(C)OC(=O)N1CCC2(CC1)Oc1ncccc1-n1nccc12,,C1CCOC1,,O,[Li]CCCC,val
US04289763,CCCCC(=O)OC(=O)CCCC.C[C@@H]1C[C@H]2[C@@H]3C[C@H](Cl)C4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO>>CCCCC(=O)OCC(=O)[C@H]1[C@H](C)C[C@H]2[C@@H]3C[C@H](Cl)C4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C,,c1ccncc1,,,,val
US20160152604A1,CC(N)C1CCOCC1.COC(=O)C(C(C)=O)c1ccccc1Br>>COC(=O)/C(=C(/C)NC(C)C1CCOCC1)c1ccccc1Br,,CCO,,CC(=O)O,,val
US20080214621A1,C=CCC(Cc1ccc(Br)c2ccccc12)C(=O)N1C(=O)OCC1Cc1ccccc1.O=[Os](=O)(=O)=O>>O=CCC(Cc1ccc(Br)c2ccccc12)C(=O)N1C(=O)OCC1Cc1ccccc1,O=[Os](=O)(=O)=O,C1CCOC1,,O,,val
US20090181942A1,COc1ccc(C=O)c(OC)c1.COc1cccc(C(O)c2c(N)cccc2Cl)c1OC>>COc1ccc(CNc2cccc(Cl)c2C(O)c2cccc(OC)c2OC)c(OC)c1,,CC(=O)O,,[BH4-].[Na+],,val
US20150011527A1,CC(C)(C)OC(=O)C1CNC1.CC(C)(C)c1ccc(C(=O)N[C@@H](Cc2ccc(-c3ncc(Br)cn3)cc2)C(=O)O)s1>>CC(C)(C)OC(=O)C1CN(C(=O)[C@H](Cc2ccc(-c3ncc(Br)cn3)cc2)NC(=O)c2ccc(C(C)(C)C)s2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140163000A1,O=[N+]([O-])c1cnccc1C1=CCN(C2COC2)CC1>>Nc1cnccc1C1CCN(C2COC2)CC1,[Pd],CCOC(C)=O,,CCO,,val
US20090156643A1,OCc1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1Cl>>O=Cc1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1Cl,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20090082464A1,CC(=O)NCCCS(=O)(=O)Cl.CC(C)(CO)OCc1ccccc1>>CC(=O)NCCCS(=O)(=O)OCC(C)(C)OCc1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20110053893A1,CCOP(=O)(/C=C/c1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OC)cc3C)cc12)OCC>>CCOP(=O)(CCc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OC)cc3C)cc12)OCC,[Pd],CCO,ClCCl,[H][H],,val
US20070259874A1,COc1ccc(C2=NOC(C)(C#N)C2)cc1OC1CCCC1.NCCS>>COc1ccc(C2=NOC(C)(C3=NCCS3)C2)cc1OC1CCCC1,,CCO,,CCN(CC)CC,Cl,val
US20110184188A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccccc1.Nc1ccc(Cn2cc(I)c(C(F)(F)C(F)(F)F)n2)cc1>>Cc1cc(Cn2cc(I)c(C(F)(F)C(F)(F)F)n2)ccc1NC(=O)OC(C)(C)C,,O,,,,val
US20160145271A1,COC(=O)C(C)(C)c1nnc(-c2nn(Cc3ccc(OC)cc3)c3nc(C)c(F)cc23)nc1Cl.N>>COc1ccc(Cn2nc(-c3nnc4c(n3)NC(=O)C4(C)C)c3cc(F)c(C)nc32)cc1,,CC#N,,,,val
US04395406,C#CCBr.CSc1nc(=O)[nH]cc1F>>C#CCn1cc(F)c(SC)nc1=O,,CN(C)C=O,,[K],,val
US20070191340A1,O=C(c1ccc(Br)cc1)N1CCC(c2ccccc2)C1.OB(O)c1ccccc1C(F)(F)F>>O=C(c1ccc(-c2ccccc2C(F)(F)F)cc1)N1CCC(c2ccccc2)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20100216758A1,CC(C)(C)OC(=O)N1CCCC1c1ccc(CCn2ccc(OCc3ccc(F)cc3)cc2=O)cc1.O=S(=O)(OCCF)C(F)(F)F>>O=c1cc(OCc2ccc(F)cc2)ccn1CCc1ccc(C2CCCN2CCF)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20100035874A1,CCOC(=O)c1c(C)[nH][nH]c1=O.Cc1ccc(C(=O)C(C)Br)c(C)c1>>CCOC(=O)c1c(OC(C)C(=O)c2ccc(C)cc2C)n[nH]c1C,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05342720,C=C(C)C(=O)OCCO.CCCCCCCCCCCCc1ccc(S(=O)(=O)O)cc1>>O=C(O)c1ccccc1O,,CCOC(C)=O,,CCCCCCC,,val
US05073556,CCOC(=O)c1cc(F)c(F)c(O)c1F.FC(F)Cl>>CCOC(=O)c1cc(F)c(F)c(OC(F)F)c1F,,CN(C)C=O,,[H-].[Na+],,val
US04956371,COC(=O)c1ccc(OC)c(OC)c1.Cc1cccc(CCN)c1>>COc1ccc(C(=O)NCCc2cccc(C)c2)cc1OC,,ClCCl,,,,val
US05770743,CC(C)(C)[Si](C)(C)Cl.O=C(OCCCCl)c1cccc(O)c1>>CC(C)(C)[Si](C)(C)Oc1cccc(C(=O)OCCCCl)c1,,CN(C)C=O,O,c1c[nH]cn1,,val
US20090048241A1,CS(=O)(=O)Cl.N#Cc1ccc(C(OCCO)c2cnc[nH]2)cc1>>CS(=O)(=O)OCCOC(c1ccc(C#N)cc1)c1cnc[nH]1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20140128390A1,CC#N.CC(C)(C)OC(=O)N1CCNCC1.O=S(=O)(c1ccccc1)n1c(I)cc2c(Cl)ncnc21>>C[C@@H]1CN(c2ncnc3c2cc(I)n3S(=O)(=O)c2ccccc2)CCN1C(=O)OC(C)(C)C,,CC#N,,CCN(CC)CC,,val
US20150238601A1,CC(C)N.O=CCOc1cccc(-c2nccc(Nc3ccc4[nH]ncc4c3)n2)c1>>CC(C)NCCOc1cccc(-c2nccc(Nc3ccc4[nH]ncc4c3)n2)c1,,CO,,[BH3-]C#N.[Na+],,val
US20100152163A1,Cc1ccc2[nH]c3c(c2c1)CCN(C)CC3.O=C(CCl)Nc1ccc(F)cc1>>Cc1ccc2c(c1)c1c(n2CC(=O)Nc2ccc(F)cc2)CCN(C)CC1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20050124654A1,CC(C)(C)OC(=O)NC1CCc2cc(CN3CCCCC3)ccc2C1.O=C(O)C(F)(F)F>>NC1CCc2cc(CN3CCCCC3)ccc2C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05750531,CCc1cc(Cl)nc(Cl)n1.c1ccc2c(c1)CCNC2>>CCc1cc(N2CCc3ccccc3C2)nc(Cl)n1,,CN(C)C=O,,CCN(CC)CC,,val
US20150315198A1,CS(=O)(=O)Cl.OCc1ccc(SC2CCCC2)cc1>>CS(=O)(=O)OCc1ccc(SC2CCCC2)cc1,,ClCCl,,,,val
US04151172,C=CCOP(=O)(CC(=O)O)OCC=C.CC(C)(C)OC(=O)[C@@H]1CCCN1>>C=CCOP(=O)(CC(=O)N1CCC[C@H]1C(=O)OC(C)(C)C)OCC=C,,CC#N,,O=C(n1ccnc1)n1ccnc1,,val
US06194585B1,CC(=O)Cl.N#CC1CC(c2cccc(Sc3ccc(N)cc3)c2)CCO1>>CC(=O)Nc1ccc(Sc2cccc(C3(C#N)CCOCC3)c2)cc1,,CCOC(C)=O,,CCN(CC)CC,,val
US20120196884A1,CN(c1ccc(NC(=O)Nc2ccccc2)cc1)S(=O)(=O)c1ccc(C2=CCCCC2)s1>>CN(c1ccc(NC(=O)Nc2ccccc2)cc1)S(=O)(=O)c1ccc(C2CCCCC2)s1,[Pd],C1CCOC1,CCOC(C)=O,[H][H],,val
US20100184815A1,CC(C)(C)OC(=O)C(C)(C)Sc1ccc(C(=O)O)cc1.CC(C)(C)c1ccc(Cn2cc(CO)nn2)cc1>>CC(C)(C)OC(=O)C(C)(C)Sc1ccc(C(=O)OCc2cn(Cc3ccc(C(C)(C)C)cc3)nn2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20080242655A1,COC(=O)CBr.COc1ccc(CNc2ccncc2C#N)cc1>>COC(=O)c1c(N)c2cnccc2n1Cc1ccc(OC)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20140179670A1,CC(C)I.O=c1ccn(-c2cccc(C(F)(F)F)c2)c(=O)[nH]1>>CC(C)n1c(=O)ccn(-c2cccc(C(F)(F)F)c2)c1=O,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20150299202A1,Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cn1ccc2c1N=CCN2.Cl>>Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cn1ccc2c1N=CCN2.Cl,,CCOC(C)=O,CO,,,val
US20070043084A1,C=C(Cl)C(=O)OCC.COc1ccc(C(=N)Nc2ccc(OCc3ccccc3)cc2)cc1>>CCOC(=O)C1CN(c2ccc(OCc3ccccc3)cc2)C(c2ccc(OC)cc2)=N1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20130225524A1,Nc1cc(Br)cc(C(=O)O)c1.OB(O)C1=CCCCC1>>Nc1cc(C(=O)O)cc(C2=CCCCC2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US05200110,Cl.N.N=C(O)c1ccc(Br)cc1>>Cl.N=C(N)c1ccc(Br)cc1,,CCO,,,,val
US20090264416A1,NC1CC(F)(F)C1.O=C(Cl)c1cccc(CCl)c1>>O=C(NC1CC(F)(F)C1)c1cccc(CCl)c1,,ClCCl,,CCN(CC)CC,Cl,val
US20050171101A1,O=C(Nc1cccc([N+](=O)[O-])c1)C1CCCCC12OCCO2>>Nc1cccc(NC(=O)C2CCCCC23OCCO3)c1,[Pd],CO,,,,val
US20090186766A1,CCOC(=O)C([NH3+])C(/C=C/c1ccccc1)c1ccccc1.CN.Cn1cc(C(=O)Cl)c(C(F)(F)F)n1>>CNC(=O)C(NC(=O)c1cn(C)nc1C(F)(F)F)C(/C=C/c1ccccc1)c1ccccc1,,CO,ClCCl,CCN(CC)CC,,val
US20130281392A1,Nc1cc(Cl)c(-c2ccc(C(F)(F)F)cc2Cl)cc1N.O=C(O)C(F)(F)C(F)(F)C(F)(F)F>>FC(F)(F)c1ccc(-c2cc3[nH]c(C(F)(F)C(F)(F)C(F)(F)F)nc3cc2Cl)c(Cl)c1,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20110319378A1,C=CC[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N([C@@H](CC)C(=O)OC)C1=O>>C=CC[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N(C(CC)C(=O)O)C1=O,,C1CCOC1,O,[Na+].[OH-],,val
US20160137636A1,CCOc1ccc(B(O)O)cc1C.COc1cc(Br)c(F)cc1-c1ncnc2cc(S(=O)(=O)Nc3ccon3)ccc12>>CCOc1ccc(-c2cc(OC)c(-c3ncnc4cc(S(=O)(=O)Nc5ccon5)ccc34)cc2F)cc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20070249670A1,CC(C)(C)OC(=O)C[C@@H](N)c1ccccc1>>CC(C)(C)OC(=O)C[C@@H](N)C1CCCCC1,[Rh],CO,,,,val
US20060172983A1,COC(=O)C(C)c1ccc2cc(O)ccc2c1.O=C(Cl)COCc1ccccc1>>COC(=O)C(C)c1ccc2cc(OC(=O)COCc3ccccc3)ccc2c1,,CC(C)=O,,CCN(CC)CC,,val
US20070232606A1,CC(C)(C)OC(=O)N1CCC(C#N)(NC(=O)O[C@@H](CC2CCCCC2)C(=O)N2CCOCC2)CC1.O=C(O)C(F)(F)F>>N#CC1(NC(=O)O[C@@H](CC2CCCCC2)C(=O)N2CCOCC2)CCNCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20090163524A1,CC(C)(C)OC(=O)NC(CCN)c1ccc(Cl)cc1.O=C(Cl)Oc1ccccc1>>CC(C)(C)OC(=O)NC(CCNC(=O)Oc1ccccc1)c1ccc(Cl)cc1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20120108566A1,CC(=O)OC(C)=O.NC(=O)c1cnc(Nc2cccc(N3CCNCC3)c2)cc1NC1(c2ccccc2)CC1>>CC(=O)N1CCN(c2cccc(Nc3cc(NC4(c5ccccc5)CC4)c(C(N)=O)cn3)c2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130331377A1,CCCCc1cc(=O)[nH]c(SC)n1.Nc1ccc(F)cc1>>CCCCc1cc(=O)[nH]c(Nc2ccc(F)cc2)n1,,CCOC(C)=O,,,,val
US20140148454A1,COc1nc(Cl)nc(OC)c1C(=O)O.NCc1ccc(Cl)cc1>>COc1nc(Cl)nc(OC)c1C(=O)NCc1ccc(Cl)cc1,,C1CCOC1,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05190934,CCOP(=O)(CC(=O)CNC(=O)OC(C)(C)C)CC1CC1.C[Si](C)(C)Br>>Br.NCC(=O)CP(=O)(O)CC1CC1,,CO,ClCCl,,,val
US20160204350A1,O=S(=O)(Cl)c1cc(Br)ccc1C=Cc1ccc(Br)cc1S(=O)(=O)Cl>>Brc1ccc2c(c1)sc1c3ccc(Br)cc3sc21,,CC(=O)O,,I,,val
US20090275578A1,COC(=O)c1c(I)cccc1CBr.NCc1ccc(Oc2ccccc2)cc1>>O=C1c2c(I)cccc2CN1Cc1ccc(Oc2ccccc2)cc1,,CCCCCC,Cc1ccccc1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20080306055A1,CCOC(=O)CC1CCNCC1.O=Cc1ccn(-c2ccc(C(F)(F)F)cc2)c1>>CCOC(=O)CC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140018345A1,COS(=O)(=O)c1ccccc1.Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(NCCCN(C)C)nc2c1-c1cccc(C(F)(F)F)c1>>Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(NCCC[N+](C)(C)C)nc2c1-c1cccc(C(F)(F)F)c1.O=S(=O)([O-])c1ccccc1,,CC(C)=O,,,,val
US20150119385A1,CC(C)Oc1cc(NC(=O)Oc2ccccc2)ncc1C#N.COC(OC)c1nc2c(cc1C1CCOC1)CCCN2>>COC(OC)c1nc2c(cc1C1CCOC1)CCCN2C(=O)Nc1cc(OC(C)C)c(C#N)cn1,CN(C)c1ccncc1,CN(C)C=O,O,,,val
US20080103123A1,Brc1ccc(OCC2CCN(Cc3ccccc3)CC2)nc1.CS(=O)(=O)c1ccc(B(O)O)cc1>>CS(=O)(=O)c1ccc(-c2ccc(OCC3CCN(Cc4ccccc4)CC3)nc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US04147804,CNc1c(C)cccc1C.O=C(Cl)Cl>>Cc1cccc(C)c1N(C)C(=O)Cl,,c1ccccc1,,Cl,,val
US20040110804A1,C=O.CC1(C)OC(=O)C(=CC(=O)N(Cc2ccc(Cl)c(Cl)c2)OCCCN2CCOCC2)O1.NCCN1CCOCC1>>O=C1C(O)=C(C(=O)N(Cc2ccc(Cl)c(Cl)c2)OCCCN2CCOCC2)CN1CCN1CCOCC1,,CO,,,,val
US20160120841A1,CC(C)(C)OC(=O)CC(=O)c1ccccc1O.COC(=O)c1cnc(C=O)s1>>COC(=O)c1cnc(/C=C(/C(=O)OC(C)(C)C)C(=O)c2ccccc2O)s1,,c1ccccc1,,C1CCNCC1,CC(=O)O,val
US05098904,O=C1CCCN1CC1CCN(c2nc(C(F)(F)F)ncc2OCc2ccccc2)CC1>>O=C1CCCN1CC1CCN(c2nc(C(F)(F)F)ncc2O)CC1,[Pd],CCO,,,,val
US20090291917A1,N#Cc1ccc(Oc2ccc(Br)c(COC3CCCCO3)c2)c(C=O)c1>>N#Cc1ccc(Oc2ccc(Br)c(COC3CCCCO3)c2)c(CO)c1,,CO,,[BH4-].[Na+],,val
US05521315,BrC(Br)(Br)Br.C=CCCCCCCCCCCCO>>C=CCCCCCCCCCCCBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06255333B1,CC(=O)c1cn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)nc1C#N.FC(F)(Br)Br>>CC(=C(F)F)c1cn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)nc1C#N,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130059834A1,CCCC[Sn](Cl)(CCCC)CCCC.CCn1nc(I)c2ccc(Cl)cc21>>CCCC[Sn](CCCC)(CCCC)c1nn(CC)c2cc(Cl)ccc12,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20070281936A1,CCCC[Sn](CCCC)(CCCC)c1ccco1.Nc1nc(Cl)cc(Cl)n1>>Nc1nc(Cl)cc(-c2ccco2)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US20060040918A1,CC(=O)O.N#Cc1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)c(F)c1.O>>O=C(O)c1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)c(F)c1,,CCO,O,[Na+].[OH-],,val
US20090124666A1,O=Cc1ccc(Cl)c(F)c1.[C-]#[N+]C(C)S(=O)(=O)c1ccc(C)cc1>>Cc1ncoc1-c1ccc(Cl)c(F)c1,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US20060025433A1,N#C[C@@H]1CC[C@H](O)CC1>>NC[C@@H]1CC[C@H](O)CC1,[Ni],CO,,N,,val
US20070203139A1,COC(=O)CBr.COc1c(C#N)cc2ccccc2c1CN(C)C(=O)C(N)c1ccc(F)cc1>>COC(=O)CNC(C(=O)N(C)Cc1c(OC)c(C#N)cc2ccccc12)c1ccc(F)cc1,,C1CCOC1,,CCN(CC)CC,,val
US05637718,CC(C)(CC=O)CCBr.CC(C)CN>>CC(C)CN1C=CC(C)(C)CC1,,CCO,O,CC(=O)O,,val
US20160023991A1,CCOC(=O)CCCCCOc1ncccc1CN(C(=O)c1ccc(-c2ccco2)cc1)C(C)C>>CC(C)N(Cc1cccnc1OCCCCCC(=O)O)C(=O)c1ccc(-c2ccco2)cc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20100069355A1,CCOC(=O)c1ccc2[nH]c3c(OC)c4[nH]c5ccc(C(=O)OCC)cc5c4cc3c2c1>>COc1c2[nH]c3ccc(C)cc3c2cc2c1[nH]c1ccc(C)cc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090227601A1,Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CC3)CC2(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)[NH+]([O-])[C@H]2CCN(C3CC3)CC2(C)C)cc1,,CC#N,,,,val
US20030013875A1,CC1(c2cccc(N)c2)C2CN(CCCc3ccccc3)CC21.CCS(=O)(=O)Cl>>CCS(=O)(=O)Nc1cccc(C2(C)C3CN(CCCc4ccccc4)CC32)c1,,ClCCl,,c1ccncc1,,val
US20070249589A1,CC(C)(C)OC(=O)N1CCC(C(=O)NN)CC1.CCOC(C)=N>>Cc1nnc(C2CCN(C(=O)OC(C)(C)C)CC2)[nH]1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US04826866,CCCCCCCNC(=S)NN.CCOC(=O)C(Cl)C(C)=O>>CCCCCCCNc1n[nH]c(C)c1C(=O)OCC.Cl,,CCO,,,,val
US20100099665A1,Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(CC(C)(C)CO[Si](C)(C)C(C)(C)C)cc(S(=O)(=O)N3CCN(C(=O)OC(C)(C)C)[C@@H](CO)C3)c2c1>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(CC(C)(C)CO)cc(S(=O)(=O)N3CCN4C(=O)OC[C@H]4C3)c2c1,,Cc1ccccc1,ClCCl,O=C(O)C(F)(F)F,,val
US20080182876A1,COc1cc(/C=C/COCCCN2CCCCC2)ccc1OCc1ccccc1>>COc1cc(CCCOCCCN2CCCCC2)ccc1O,[Pd],CO,,,,val
US20110207704A1,CCOC(=O)[C@@H]1CC[C@H](Nc2ccc(-c3noc(-c4cnc(OC(C)C)c(Br)c4)n3)cc2)C1>>CC(C)Oc1ncc(-c2nc(-c3ccc(N[C@H]4CC[C@@H](C(=O)O)C4)cc3)no2)cc1Br,,CCO,,C1CCOC1,[Na+].[OH-],val
US20140121187A1,CC(=O)NC1(c2ccc(C(C)C)cc2OC(=O)N(C)C)C(=O)c2cccc([N+](=O)[O-])c2C1=O>>CC(=O)NC1(c2ccc(C(C)C)cc2OC(=O)N(C)C)C(=O)c2cccc(N)c2C1=O,[Fe],CCO,O,Cl,,val
US05885999,CC(C)(C)OC(=O)N1CCN(c2ccccc2CNS(C)(=O)=O)CC1.Cl>>CS(=O)(=O)NCc1ccccc1N1CCNCC1.Cl,,CO,,,,val
US20120329780A1,CN1CCN(c2ccc(N)cc2)CC1.COC(=O)Cc1cccc(-c2nc(Cl)c3nn(Cc4ccc(OC)cc4)cc3n2)c1>>CN1CCN(c2ccc(Nc3nc(-c4cccc(CC(=O)O)c4)nc4cn[nH]c34)cc2)CC1,C1COCCO1,CO,,Cl,,val
US20020019569A1,CC(COCCCCOS(C)(=O)=O)=NOC(C)(C)C.Oc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl>>CC(COCCCCOc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl)=NOC(C)(C)C,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US04560401,CCC1CN(C(c2ccccc2)c2ccccc2)C1C(=O)O>>CCC1CNC1C(=O)O,[Pd],CCO,,[H][H],,val
US20080234501A1,CC(=O)[O-].Cc1ccc(C)c(C2(CCl)OCC(C)(C)CO2)c1.OCCO>>Cc1ccc(C)c(CC(=O)O)c1,,O,OCCO,[Na+].[OH-],,val
US20110070317A1,CO[C@H](C)C(=O)O.Nc1c[nH]c2ncc(C(F)(F)F)c(Cl)c12>>CO[C@H](C)C(=O)Nc1c[nH]c2ncc(C(F)(F)F)c(Cl)c12,,ClCCl,,CCN(CC)CC,O=C1OCCN1P(=O)(Cl)N1CCOC1=O,val
US20130261105A1,CC(C)(C)OC(=O)N1CCc2cc(Cl)nnc2CC1.O=C(O)C(F)(F)F>>Clc1cc2c(nn1)CCNCC2.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20160222028A1,COC(=O)c1ccc2c(c1)OCCN(C(=O)C(C)(C)C)C2.NO>>CC(C)(C)C(=O)N1CCOc2cc(C(=O)NO)ccc2C1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US04996330,CCCCCCCCN.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>O=C1NC(=O)C(O)C1O,,O,,,,val
US20120309738A1,CN.O=[N+]([O-])c1cc(Cl)c(Cl)cc1F>>CNc1cc(Cl)c(Cl)cc1[N+](=O)[O-],,CN(C)C=O,,,,val
US20090118501A1,C1CCC(NC2CCCCC2)CC1.C1CCOC1.CCOC(=O)CNS(=O)(=O)c1cnc(N)s1>>CCOC(=O)CNS(=O)(=O)c1cnc(NC(=O)N(C2CCCCC2)C2CCCCC2)s1,CN(C)c1ccncc1,,,,,val
US20150105373A1,CC[Mg]Br.O=Cc1ccc2c(c1)OC(F)(F)O2>>CCC(O)c1ccc2c(c1)OC(F)(F)O2,,C1CCOC1,,[Cl-].[NH4+],,val
US20130041007A1,CC(C)(C)OC(=O)n1c2c(c3cc(Cl)c(Cl)cc31)CCCC2=O>>O=C1CCCc2c1[nH]c1cc(Cl)c(Cl)cc21,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20090209607A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H](Cc1c(F)cccc1F)C(=O)O>>CC(C)(C)OC(=O)N[C@@H](Cc1c(F)cccc1F)C(=O)O,,C1COCCO1,O,Cl,[Na+].[OH-],val
US05747499,CC(=O)Nc1cc2c(cc1Br)CCC2.ClCCl.N>>CC(=O)Nc1cc2c(cc1C#N)CCC2,,ClCCl,,CN1CCCC1=O,,val
US20150361079A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.O=C1c2ccc(Br)cc2NC2(CCN(Cc3ccc(F)c(F)c3)CC2)N1c1ccc(OC(F)(F)F)cc1>>CC(=O)c1ccc2c(c1)NC1(CCN(Cc3ccc(F)c(F)c3)CC1)N(c1ccc(OC(F)(F)F)cc1)C2=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20090156642A1,CN(Cc1cc(S(=O)(=O)c2ccccc2)n(-c2cccnc2F)n1)C(=O)OC(C)(C)C.CO>>COc1ncccc1-n1nc(CN(C)C(=O)OC(C)(C)C)cc1S(=O)(=O)c1ccccc1,,CO,,C[O-].[Na+],,val
US20130116243A1,CC(C)c1nnc2n1-c1cc(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)nc1OC2>>CC(C)c1nnc2n1-c1cc(-c3ccccc3)c(-c3ccc(C4(N)CCC4)cc3)nc1OC2,,O=C(O)C(F)(F)F,,,,val
US20090075938A1,Cc1ccc(-c2nc3cc([N+](=O)[O-])ccc3s2)cc1>>Cc1ccc(-c2nc3cc(N)ccc3s2)cc1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20090036421A1,COc1ccccc1-c1cc(C(=O)N=C(N)N)c(C)n1CCc1ccc(F)cc1.ClCCl>>Cc1c(C(=O)N=C(N)N)cc(-c2ccccc2O)n1CCc1ccc(F)cc1.Cl,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US05095014,CN.O=C(Cl)N1CC(Oc2ccccc2Cl)C1>>CNC(=O)N1CC(Oc2ccccc2Cl)C1,,C1CCOC1,O,,,val
US20150038528A1,CCOC(=O)c1nc(I)c2cc(Br)ccc2c1O.CN1CCCC1=O>>CCOC(=O)c1nc(C#N)c2cc(Br)ccc2c1O,,ClCCl,,,,val
US20070117854A1,FC(F)(F)c1nn(CCl)cc1Br.N#CC(C#N)CCC(F)(F)F>>N#CC(C#N)(CCC(F)(F)F)Cn1cc(Br)c(C(F)(F)F)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04161538,CCOC(=O)Cc1ccc(CC2(C(=O)OCC)CCCC2=O)cc1>>O=C(O)Cc1ccc(CC2CCCC2=O)cc1,,C1COCCO1,,Br,,val
US20080015199A1,COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(OC)c2c(c1)OCCCO2.COC(=O)c1scnc1NN>>COC(=O)c1scnc1-n1nc(C(Nc2ccc(-c3noc(C)n3)cc2)c2cc(OC)c3c(c2)OCCCO3)[nH]c1=O,,C1CCOC1,,CCN(CC)CC,,val
US20100324086A1,CC(C)(C)OC(=O)Nc1cccc(C(=O)O)c1.Nc1ccccc1Cl>>CC(C)(C)OC(=O)Nc1cccc(C(=O)Nc2ccccc2Cl)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060135537A1,CN(C)CCC(=O)c1ccccc1.Nc1nn2cc(Br)cnc2c1-c1ccccn1>>Nc1nn2c(c1-c1ccccn1)N=C(c1ccccc1)CC2,,CN(C)C=O,,Cl,O,val
US20100029650A1,CC(C)(C)OC(=O)NCCNS(=O)(=O)c1ccc(-c2ccc(O)cc2)cc1.CC(C)c1noc(N2CCC(CO)CC2)n1>>CC(C)c1noc(N2CCC(COc3ccc(-c4ccc(S(=O)(=O)NCCNC(=O)OC(C)(C)C)cc4)cc3)CC2)n1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110039866A1,CCC(Cl)(Cl)C=O.NC(=O)c1ccc(Br)cc1>>CCC(Cl)(Cl)C(O)NC(=O)c1ccc(Br)cc1,Cl,C1COCCO1,,,,val
US20090018132A1,Cn1cc2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCN(C(=O)OC(C)(C)C)CC3)c2n1>>Cn1cc2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)c2n1,,O=C(O)C(F)(F)F,,,,val
US05338857,COc1ccc(C=NO)cc1.O=C1CCC(=O)N1Cl>>COc1ccc(C(=O)NCl)cc1,,CN(C)C=O,,O,,val
US03992535,COC(=O)C1=C(O)c2ccc3ccccc3c2S(=O)(=O)N1C.Nc1nc2ccccc2s1>>CN1C(C(=O)Nc2nc3ccccc3s2)=C(O)c2ccc3ccccc3c2S1(=O)=O,,Cc1ccccc1C,,,,val
US04933355,CCOC(=O)C(=O)c1csc(N)n1.COc1ccccc1N=C=O>>CCOC(=O)C(=O)c1csc(NC(=O)Nc2ccccc2OC)n1,,CN(C)C=O,,,,val
US20100179128A1,C=CCn1c(Cl)nc2c1c(=O)[nH]c(=O)n2CCCC.CCOC(=O)CBr>>CCCCn1c(=O)n(CC(=O)OCC)c(=O)c2[nH]c(Cl)nc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04289697,O=C(O)C(Br)c1ccccc1.S=C1CCCCCN1>>Oc1c(-c2ccccc2)sc2[n+]1CCCCC2.[Br-],,CCOCC,,CC(=O)O,,val
US20110301175A1,CS(=O)(=O)Cl.OCCOc1ccc(Nc2ncc(Br)cn2)cc1>>CS(=O)(=O)OCCOc1ccc(Nc2ncc(Br)cn2)cc1,,ClCCl,,CCN(CC)CC,,val
US20020161241A1,O=C(Cl)c1ccccc1.O[C@H]1CCN(Cc2ccccc2)C1>>Cl.O=C(O[C@H]1CCN(Cc2ccccc2)C1)c1ccccc1,,ClCCl,,COC(C)(C)C,,val
US20090042874A1,CC(C)(C)OC(=O)N1CCC(O)CC1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCC(OS(=O)(=O)c2ccccc2[N+](=O)[O-])CC1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20160060257A1,COc1ccc(F)cc1-c1ccnc2c1cc(C1(O)CC3(CNC3)C1)n2S(=O)(=O)c1ccc(C)cc1>>COc1ccc(F)cc1-c1ccnc2[nH]c(C3(O)CC4(CNC4)C3)cc12,,C1COCCO1,,[Na+].[OH-],,val
US20080032998A1,O=C(O)c1cc([N+](=O)[O-])[nH]n1>>Nc1cc(C(=O)O)n[nH]1,[Pd],CO,,[H][H],,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4c(Br)cccc4nn23)CC1.OB(O)c1ccsc1>>CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4c(-c5ccsc5)cccc4nn23)CC1,,C1CCOC1,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20060142612A1,O=C1OCCN1c1ccccc1.O=S(=O)(O)Cl>>O=C1OCCN1c1ccc(S(=O)(=O)Cl)cc1,,ClC(Cl)(Cl)Cl,,,,val
US20060100246A1,CC(C)(C)OC(=O)N1CCCC(c2cc(-c3c(O)cccc3OCC3CC3)nc(N)c2CNC(=O)NC2CCCCC2)C1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1CCCC(c2cc(-c3c(O)cccc3OCC3CC3)nc3c2CN(C(=O)NC2CCCCC2)C(=O)N3)C1,,C1CCOC1,,CCN(CC)CC,,val
US20100087429A1,CC1(C#Cc2cnc3c(c2)[C@]2(COC(N)=N2)c2cc(OS(=O)(=O)C(F)(F)F)ccc2O3)COC1.OB(O)c1cccnc1F>>CC1(C#Cc2cnc3c(c2)[C@]2(COC(N)=N2)c2cc(-c4cccnc4F)ccc2O3)COC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,,O=C([O-])[O-].[K+].[K+],,val
US20100286145A1,CC(C)(C)OC(=O)NC/C(N)=N/O.CCOC(C)=O>>Cc1nc(CNC(=O)OC(C)(C)C)no1,,CCO,,C,C[O-].[Na+],val
US20150011574A1,CC(C)(C)OC(=O)CCC(=O)Nc1ncc(C(=O)NCc2cccc(-c3ccccc3)c2)c(O)n1>>O=C(O)CCC(=O)Nc1ncc(C(=O)NCc2cccc(-c3ccccc3)c2)c(O)n1,,O=C(O)C(F)(F)F,,CCOCC,,val
US20150252038A1,CC(C)(C)OC(=O)c1cc(Cl)c(F)cc1F.CC1(C)OCC(CO)CO1>>CC(C)(C)OC(=O)c1cc(Cl)c(OCC2COC(C)(C)OC2)cc1F,,CS(C)=O,O,CC(C)(C)[O-].[K+],,val
US04673683,CC(CCl)Cc1ccc(C(C)(C)C)cc1.OC1CCNCC1>>CC(Cc1ccc(C(C)(C)C)cc1)CN1CCC(O)CC1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20100158996A1,CCOC(=O)C(C(=O)OCC)c1ccc([N+](=O)[O-])c(C)c1>>Cc1cc(CC(=O)O)ccc1[N+](=O)[O-],,CO,O,[K+].[OH-],,val
US20130066055A1,CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCCO1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCCCCCN)C(C)C.O=C(Cl)CBr>>CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCCO1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCCCCCNC(=O)CBr)C(C)C,,C1CCOC1,,CCN(CC)CC,,val
US20040063775A1,CCOP(=O)(CCOC(C)=O)OCC.O=Cc1cc(OCc2ccccc2)nn1-c1ccccc1>>CCOC(=O)/C=C/c1cc(OCc2ccccc2)nn1-c1ccccc1,,O,,CN(C)C=O,[H-].[Na+],val
US04154834,CCO.O=C([O-])C=Cc1cnc2ccccc2c1>>CCOC(=O)CCc1cnc2ccccc2c1,[Pd],,,,,val
US20080275057A1,FC(F)(F)c1ccc(Cl)nc1Cl.NN>>NNc1ccc(C(F)(F)F)c(Cl)n1,,CCO,,O,,val
US05100891,ON=C1CCc2c1[nH]c1ccccc21>>NC1CCc2c1[nH]c1ccccc21,[Ni],CCO,O,[Na+].[OH-],,val
US04822787,CS(=O)(=O)Cl.O=C(O)COC[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccc([N+](=O)[O-])cc1>>CS(=O)(=O)O[C@@H]1C[C@@H](COCC(=O)O)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1,,ClCCl,O,CCN(CC)CC,Cl,val
US06716878B1,C1COCCN1.CC(C)(C)OC(=O)N[C@H](C(=O)c1ccc(F)cc1)C(C)(C)C>>CC(C)(C)OC(=O)N[C@H](C(=O)c1ccc(N2CCOCC2)cc1)C(C)(C)C,,CS(C)=O,,CCN(CC)CC,,val
US20130317212A1,C1=Nc2ccccc2Oc2ccccc21.CC(=O)/C(C)=N/O>>Cc1nc2n(c1C)-c1ccccc1Oc1ccccc1-2,[Zn],CC(=O)O,,,,val
US20130190312A1,Cc1cc(Oc2ncccn2)cc(C)c1C(=O)CBr.NC(N)=S>>Cc1cc(Oc2ncccn2)cc(C)c1-c1csc(N)n1,,CCO,,,,val
US20110136795A1,COC(=O)Cc1c(F)ccc2ccc(OC)nc12.N#CCBr>>COC(=O)C(CC#N)c1c(F)ccc2ccc(OC)nc12,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20150191465A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@H](N)c1nc2ccn(C)c2cc1N1CCCC(O)C1>>C[C@H](NC(=O)OC(C)(C)C)c1nc2ccn(C)c2cc1N1CCCC(O)C1,,C1CCOC1,,,,val
US20040229858A1,COC(=O)c1ccc(OC[C@@H]2C[C@H](Oc3ccc4ccccc4c3)CN2)cc1.COc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1Cl>>COC(=O)c1ccc(OC[C@@H]2C[C@H](Oc3ccc4ccccc4c3)CN2C(=O)Cc2ccc(NC(=O)Nc3ccccc3Cl)c(OC)c2)cc1,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20040209948A1,CC(C)(C)OC(=O)N1CCC(N)CC1.O=S(=O)(Cl)c1ccc(F)c2ccccc12>>CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2ccc(F)c3ccccc23)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20100197687A1,CC(C)(C)c1ccc(-c2ccc3c(c2)cc(CO)n3-c2ccc(OC3CCCC3)cc2)cc1>>CC(C)(C)c1ccc(-c2ccc3c(c2)cc(C=O)n3-c2ccc(OC3CCCC3)cc2)cc1,O=[Mn]=O,ClCCl,,,,val
US03965100,Cl.O=c1c2c(nc3c(OCc4ccccc4)cccn13)CCC2>>Cl.O=c1c2c(nc3c(OCc4ccccc4)cccn13)CCC2,,CCOCC,,,,val
US20050080074A1,CC(C)(C)OC(=O)NCCNC(=O)c1ccccc1O>>NCCNC(=O)c1ccccc1O,,ClCCl,,Cl,,val
US05807860,CCCCCNC(=O)Cc1cc(Br)cc2c1OCO2.c1c[nH]cn1>>CCCCCNC(=O)Cc1cc(-c2ncc[nH]2)cc2c1OCO2,,CCOC(C)=O,,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US20110195954A1,OCc1cncc2ccccc12>>OCC1CNCc2ccccc21,O=[Pt]=O,CO,,Cl,,val
US20100197591A1,CCOC(=O)CCN(C(=O)CC#N)c1ccc(C(C)(C)C)cc1>>CC(C)(C)c1ccc(N2CCC(O)=C(C#N)C2=O)cc1,,CO,,,,val
US20120101083A1,CCOc1ncc(-c2nc(-c3ccc4c(c3)CCN(C(=O)OC(C)(C)C)CC4)no2)cc1C#N>>CCOc1ncc(-c2nc(-c3ccc4c(c3)CCNCC4)no2)cc1C#N,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120122780A1,Cc1ccc(-c2c(S[Si](C(C)C)(C(C)C)C(C)C)cnn2C)c(Cl)c1.O=C(O)C(F)(F)F>>Cc1ccc(-c2c(SCC(=O)O)cnn2C)c(Cl)c1,,ClCCl,,,,val
US20070161653A1,CS(=O)c1nccc(-c2c(-c3ccnc(F)c3)nn3ccccc23)n1.NC1CC1>>Fc1cc(-c2nn3ccccc3c2-c2ccnc(NC3CC3)n2)ccn1,,CC(C)=O,,ClCCl,,val
US20060013868A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNc1ncccc1CO>>CNc1ncccc1COC(=O)OC(C)(C)C,CN(C)c1ccncc1,C1CCOC1,,O,,val
US07223772B1,COC(=O)c1c(-c2cccc(F)c2)nn2cc(C(F)(F)F)ccc12>>O=C(O)c1c(-c2cccc(F)c2)nn2cc(C(F)(F)F)ccc12,,CCO,,Cl,[Na+].[OH-],val
US04153679,CC(C)C(C)(C(=O)Cl)C(C)C.CCOC(=O)CN>>CCOC(=O)CNC(=O)C(C)(C(C)C)C(C)C,,CCOCC,O,Cl,O=C([O-])O.[Na+],val
US04369309,CCCCN.Cc1ccc(S(=O)(=O)OCC2CCn3c(nc4ccccc43)S2)cc1>>CCCCNCC1CCn2c(nc3ccccc32)S1,,ClC(Cl)Cl,,O,[H-].[Na+],val
US20050070549A1,N#CC1(Nc2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1.O=S(=O)(O)O>>NC(=O)C1(Nc2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1,,O=S(=O)(O)O,,[NH4+].[OH-],,val
US20120329785A1,CN(C)c1ccc(N)cc1.COc1ccc(Cn2cc3c(n2)c(Cl)nc2cc(OC)c(OC)cc23)cc1>>COc1cc2nc(Nc3ccc(N(C)C)cc3)c3n[nH]cc3c2cc1OC,C1COCCO1,CO,,Cl,,val
US04868310,C=C(C)C#N.CC=C(C)C.O=S(=O)(O)O>>C=C(C)C(=O)NC(C)(C)CC,,CC(=O)O,,O,,val
US20050137171A1,CP(=O)(Cl)c1ccccc1.O=[N+]([O-])c1ccc(O)cc1>>CP(=O)(Oc1ccc([N+](=O)[O-])cc1)c1ccccc1,,C1CCOC1,O,[H-].[Na+],,val
US20050009706A1,CCC(CC)C(N)=C(C)C#N.O=C(Cl)Cl>>CCC(CC)/C(N)=C(\C#N)C(=O)Cl,,Cc1ccccc1,,,,val
US20090182007A1,COC(=O)c1cncn1C1c2ccccc2C(=O)N(C)C1(C)C>>CN1C(=O)c2ccccc2C(n2cncc2CO)C1(C)C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05382590,CSc1cccc(NC(=O)NCC(=O)N(CC(=O)N2CCCc3ccccc32)c2ccccc2)c1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1cccc(NC(=O)NCC(=O)N(CC(=O)N2CCCc3ccccc32)c2ccccc2)c1,,ClCCl,,,,val
US05753664,Cc1cccc2nc(SCc3ccc(C(=O)c4ccc(O)cc4)cc3)n(C)c(=O)c12.O=CN1CCN(C(=O)c2ccc(CCl)cc2)CC1>>Cc1cccc2nc(SCc3ccc(C(=O)c4ccc(OCc5ccc(C(=O)N6CCN(C=O)CC6)cc5)cc4)cc3)n(C)c(=O)c12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04304772,CN(C)C(=O)C1CC2CCC1c1c2c2ccccc2n1C>>CN(C)CC1CC2CCC1c1c2c2ccccc2n1C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060022584A1,CC1=CC(=C(C#N)C#N)C=C(c2ccccc2)O1.O=Cc1ccc(N2N=C(c3ccccc3)CC2c2ccccc2)cc1>>N#CC(C#N)=C1C=C(C=Cc2ccc(N3N=C(c4ccccc4)CC3c3ccccc3)cc2)OC(c2ccccc2)=C1,,CCO,,C1CCNCC1,,val
US20130261129A1,BrCCC(CBr)c1ccccc1.CC#N.N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)OCc2ccccc2)C1>>O=C(OCc1ccccc1)[C@@]12CCC[C@@H]1C[C@@H](N1CCC(c3ccccc3)CC1)C2,,CC#N,,CCN(C(C)C)C(C)C,O,val
US20130303572A1,BrC(c1ccccc1)c1ccccc1.O=Cc1ccc(O)cc1>>O=Cc1ccc(OC(c2ccccc2)c2ccccc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150038437A1,CC(C)(C)[Si](C)(C)Cl.OCCc1cc2cc(Br)ccc2[nH]1>>CC(C)(C)[Si](C)(C)OCCc1cc2cc(Br)ccc2[nH]1,,ClCCl,,c1c[nH]cn1,,val
US20150291595A1,COc1cccc(C(=O)Nc2cncc(B(O)O)c2)c1.Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3Br)n(-c3ccccc3)c(=O)c12>>COc1cccc(C(=O)Nc2cncc(-c3c(N)ncnc3N[C@@H](C)c3nn4ccc(C)c4c(=O)n3-c3ccccc3)c2)c1,,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05705515,CCCCCCCCI.O=C1NCCN1c1ccccc1>>CCCCCCCCN1CCN(c2ccccc2)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US04997667,CCOC(=O)CCNC(=O)Nc1ccncc1>>O=C(O)CCNC(=O)Nc1ccncc1,,CO,O,[Na+].[OH-],,val
US20030191118A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.COc1cc(CO)cc(OC)c1>>COc1cc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cc(OC)c1,,CN(C)C=O,,c1c[nH]cn1,,val
US20100234415A1,CCOC(=O)CCC(=O)CCC(=O)OCC.CCOC(OCC)OCC>>CCOC(=O)CCC(CCC(=O)OCC)(OCC)OCC,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20110015196A1,CCOC(=O)C1(Cc2ccccc2)CCN(C(=O)OC(C)(C)C)CC1>>CCOC(=O)C1(Cc2ccccc2)CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20070037802A1,Cc1ccc(S(=O)(=O)OCCCOc2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)cc1.NC1CC1>>O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(OCCCNC3CC3)cc12,,C1CCOC1,,,,val
US20060211603A1,Cn1c(=O)n(CC(=O)OCc2ccccc2)c2ccccc21>>Cn1c(=O)n(CC(=O)O)c2ccccc21,[Pd],CCOC(C)=O,,,,val
US20050209274A1,CO.COCOc1cc(F)c(F)cc1C(C)=O>>COCOc1cc(OC)c(F)cc1C(C)=O,,CO,,C[O-].[Na+],,val
USH0001401,C[Si](C)(C)Cl.OCc1ccccc1Br>>C[Si](C)(C)OCc1ccccc1Br,,ClCCl,,CCN(CC)CC,,val
US20140080798A1,Cc1cnc(Nc2ccc(C3CCN(C(=O)OC(C)(C)C)CC3)nc2)nc1CCc1ccccc1CC(N)=O>>Cc1cnc(Nc2ccc(C3CCNCC3)nc2)nc1CCc1ccccc1CC(N)=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110112096A1,Cc1cc(Nc2nc(Nc3cc(C)c(C4CCNCC4)cn3)ncc2Cl)n[nH]1.NC(=O)CBr>>Cc1cc(Nc2nc(Nc3cc(C)c(C4CCN(CC(N)=O)CC4)cn3)ncc2Cl)n[nH]1,,CN(C)C=O,,CCN(CC)CC,,val
US20110269787A1,CC(C)N=C=NC(C)C.CN(C)C=O.ClC(Cl)Cl.O.S=C(Nc1nc2ccccc2s1)n1ccnc1>>c1ccc2sc(NC3=NC[C@@]4(CN5CCC[C@H]4C5)O3)nc2c1,,O,,Cl,,val
US20090281097A1,CC(C)(C)OC(=O)N1CCC(N2CCNC(C(=O)N3CCOCC3)C2)CC1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCC(N2CCN(C(=O)C(F)(F)F)C(C(=O)N3CCOCC3)C2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20120202867A1,CON=C(C)C1CC1c1c(Cl)cccc1Cl>>CONC(C)[C@@H]1C[C@H]1c1c(Cl)cccc1Cl,,CCO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20160176868A1,CC(C)(C)OC(=O)N[C@@H](c1ccccc1)C(F)(F)C(=O)O.CC(C)N1C(=O)CC(=O)NC1=O>>CC(C)N1C(=O)NC(=O)C(C(=O)C(F)(F)[C@@H](NC(=O)OC(C)(C)C)c2ccccc2)C1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05849911,CC(C)(C)OC(=O)NN(Cc1ccc(-c2cncs2)cc1)C[C@H](O)[C@@H](N)Cc1ccccc1.CC[C@H](C)[C@H](NC(=O)OC)C(=O)O>>CC[C@H](C)[C@H](NC(=O)OC)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2cncs2)cc1)NC(=O)OC(C)(C)C,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20130079324A1,CN(C)CC(O)CO.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCC(O)CN(C)C)cc1,,ClCCl,,CCN(CC)CC,,val
US20130102609A1,CC(C)(C)OC(=O)COc1ccc(C=O)cc1-c1cc(F)cc(C#N)c1.CN>>CNCc1ccc(OCC(=O)OC(C)(C)C)c(-c2cc(F)cc(C#N)c2)c1,,C1CCOC1,CO,O,[BH4-].[Na+],val
US20030055047A1,COc1ccccc1-c1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1C.O=C(Cl)C(Cl)(Cl)Cl>>COc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)C(Cl)(Cl)Cl)n3Cc3ccccc32)cc1C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100298336A1,CCc1ccnc(CC)c1CBr.Cc1cc(O)nc(S)n1>>CCc1ccnc(CC)c1CSc1nc(C)cc(O)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110015156A1,CO.O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1CO>>COCN1C(=O)CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc21,,ClCCl,,O=S(Cl)Cl,O=C([O-])O.[Na+],val
US20060052396A1,CNC.O=S(=O)(Cl)c1ccc(Br)s1>>CN(C)S(=O)(=O)c1ccc(Br)s1,,C1CCOC1,,CCOC(C)=O,O,val
US20080280906A1,Cc1oncc1NC(=O)C1CCC1.Cl>>Cc1oncc1NCC1CCC1.Cl,,C1CCOC1,C1COCCO1,CO,,val
US07112553B1,CC(=O)OC(C)=O.COC(=O)Cc1ccc(N)cc1.O=[N+]([O-])O>>COC(=O)Cc1ccc(NC(C)=O)c([N+](=O)[O-])c1,,O,,,,val
US20120029190A1,O=C(Cl)OCc1ccccc1.O=C1CCCNCC1>>O=C1CCCN(C(=O)OCc2ccccc2)CC1,,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090221551A1,O=C(OO)c1cccc(Cl)c1.c1ccc2c(c1)ncc1nc3n(c12)OCCCC3>>[O-][n+]1cc2nc3n(c2c2ccccc21)OCCCC3,,ClCCl,,,,val
US20060041128A1,CCC(c1nc2snc(C)c2c(=O)n1Cc1ccccc1)N(CCCNC(=O)OC(C)(C)C)C(=O)c1ccc(C)cc1.Cl>>CCC(c1nc2snc(C)c2c(=O)n1Cc1ccccc1)N(CCCN)C(=O)c1ccc(C)cc1.[Cl-],,CCOCC,,,,val
US20150065705A1,CC(C)(C)OC(=O)N1CC=C(c2ccc(F)cc2)C(O)C1.O=C1NC(=O)c2ccccc21>>CC(C)(C)OC(=O)N1CC=C(c2ccc(F)cc2)C(N2C(=O)c3ccccc3C2=O)C1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060189591A1,COC(=O)c1nc(-c2ccccc2)n(-c2ccccc2)c1C>>Cc1c(C(=O)O)nc(-c2ccccc2)n1-c1ccccc1,,CO,,[Na+].[OH-],,val
US20090176823A1,CNC(=O)Cc1ccc(Cl)c(CN(C(=O)OC(C)(C)C)C2CC2)c1>>CNC(=O)Cc1ccc(Cl)c(CNC2CC2)c1,,ClCCl,,Cl,[Na+].[OH-],val
US20090048239A1,COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(C(=O)OC)N(C)c1ccccc1-3>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(CO)N(C)c1ccccc1-3,,C1CCOC1,,[BH4-].[Li+],,val
US20090105253A1,CCNC(=O)c1ccc(-n2cc(C(=O)NC3CC3)nn2)c(OCCCl)c1>>C=COc1cc(C(=O)NCC)ccc1-n1cc(C(=O)NC2CC2)nn1,,CN(C)C=O,,O,[H-].[Na+],val
US20090239876A1,COC(=O)CC(=O)Cl.NCc1ccc(Br)cc1>>COC(=O)CC(=O)NCc1ccc(Br)cc1,,CC#N,,CCN(CC)CC,Cl,val
US04767769,CNC(=O)Cc1ccc(N)c([N+](=O)[O-])c1>>CNC(=O)Cc1ccc(N)c(N)c1,,O,,[Cl-].[NH4+],,val
US20100105680A1,CC1([C@@H]2C[C@H](CCN3CCOCC3)C2(C)C)OCCO1>>CC(=O)[C@@H]1C[C@H](CCN2CCOCC2)C1(C)C,,CO,,Cl,,val
US07393843B2,CNS(=O)(=O)c1cc2ccccc2cc1CC(=O)O>>CN1C(=O)Cc2cc3ccccc3cc2S1(=O)=O,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05114945,COC(=O)C1CC(=O)CCN1C(=O)OCc1ccccc1.OCCO>>COC(=O)C1CC2(CCN1C(=O)OCc1ccccc1)OCCO2,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20160215288A1,COc1ccc(C(OCc2cc(Br)cc(CO)c2)(c2ccccc2)c2ccc(OC)cc2)cc1.OB(O)c1cccc(OCc2ccccc2)c1>>COc1ccc(C(OCc2cc(CO)cc(-c3ccccc3)c2)(c2ccccc2)c2ccc(OC)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20140228360A1,CC(C)(C)OC(=O)N(Cc1cccc(OCC2CO2)c1)C1CCCC1.c1ccc2c(c1)CNC2>>CC(C)(C)OC(=O)N(Cc1cccc(OCC(O)CN2Cc3ccccc3C2)c1)C1CCCC1,,CCO,,,,val
US20140206680A1,Cc1nn(C)c2sc(C(=O)O)cc12>>Cc1nn(C)c2sccc12,[Cu],,,c1ccc2ncccc2c1,,val
US20130142757A1,CNN.N#CCC(=O)C1CCCCN1.O=COCc1ccccc1>>Cn1nc(C2CCCCN2)cc1N.O=COCc1ccccc1,,CCOC(C)=O,,CCO,,val
US20070167443A1,CON(C)C(=O)c1ccc(Cl)cc1.Cc1cccc(Cn2cc(I)c(=O)c3ccccc32)n1>>Cc1cccc(Cn2cc(C(=O)c3ccc(Cl)cc3)c(=O)c3ccccc32)n1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20140288081A1,CC(CC1(O)CCNCC1)C(F)F.O=C(O)c1ccc(NS(=O)(=O)c2cccc3scnc23)cc1>>CC(CC1(O)CCN(C(=O)c2ccc(NS(=O)(=O)c3cccc4scnc34)cc2)CC1)C(F)F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05478851,CCOC(=O)c1ccccc1.CNCCO>>CN(CCO)C(=O)c1ccccc1,,O,,,,val
US20160145218A1,CCOC(=O)CBr.Cc1sc2c(=O)[nH]ncc2c1C>>CCOC(=O)Cn1ncc2c(C)c(C)sc2c1=O,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20160039834A1,COCOc1cccc(-c2nc(Cl)c(C)c(-c3c(C)noc3C)n2)c1.O=C1CCC(=O)N1Cl>>COCOc1ccc(Cl)c(-c2nc(Cl)c(C)c(-c3c(C)noc3C)n2)c1,,CN(C)C=O,,CCOC(C)=O,,val
US20040259912A1,CC(C)C(=O)c1cc(N)ccc1OC(c1ccccc1)c1ccccc1.Nc1ccc2[nH]cnc2c1.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O>>CC(C)Cc1cc(NC(=O)Nc2ccc3nc[nH]c3c2)ccc1OC(c1ccccc1)c1ccccc1,,CC#N,O,CCN(C(C)C)C(C)C,,val
US20080019915A1,COc1cccnc1Br.O=[N+]([O-])O>>COc1ccc([N+](=O)[O-])nc1Br,,O=S(=O)(O)O,,,,val
US20160068532A1,C[C@H](c1ccccc1)N1Cc2cc3c(I)nn(C(c4ccccc4)(c4ccccc4)c4ccccc4)c3cc2NC1=O.OC1CCOC1>>C[C@H](c1ccccc1)N1Cc2cc3c(OC4CCOC4)n[nH]c3cc2NC1=O,,Cc1ccccc1,,,,val
US05556864,CC(C)(C)OC(=O)N1CCCC(COc2ccccc2CCc2cccc(OC(F)F)c2)C1.Cl>>Cl.FC(F)Oc1cccc(CCc2ccccc2OCC2CCCNC2)c1,,C1COCCO1,,,,val
US20150274723A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@H]1CCCC[C@H]1NC(=O)C(F)(F)F>>CC(C)(C)OC(=O)N[C@@H]1CCCC[C@@H]1NC(=O)C(F)(F)F,,CCO,,,,val
US20060173018A1,Cc1ccc2c(Cl)nc(-c3ccccc3O)nc2c1.O=C(N[C@H]1CCCNC1)OCc1ccccc1>>Cc1ccc2c(N3CCC[C@H](NC(=O)OCc4ccccc4)C3)nc(-c3ccccc3O)nc2c1,,ClCCl,,CCN(CC)CC,,val
US20050176701A1,COc1ccc(Br)cc1C(C)=O>>COc1ccc(Br)cc1C(C)O,,ClCCl,,,,val
US20130158041A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cn1cc(-n2ccc(=O)c(CCc3ccc4ncccc4c3)n2)cn1>>Cn1cc(-n2ccc(=S)c(CCc3ccc4ncccc4c3)n2)cn1,,C1COCCO1,,,,val
US20030078251A1,CC(C)Oc1ccc(C=O)cc1[N+](=O)[O-].CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)C=Cc1ccc(OC(C)C)c([N+](=O)[O-])c1,,CCOC(C)=O,,C1CCOC1,,val
US20090239911A1,Clc1cc(Br)ccc1CBr.O=C1CCCN1C1CCC(F)(F)CC1>>O=C1C(Cc2ccc(Br)cc2Cl)CCN1C1CCC(F)(F)CC1,,C1CCOC1,CCCCCC,CC(C)[N-]C(C)C.[Li+],,val
US20100298558A1,C[N+](=O)[O-].O=C(C=C(c1cc(Cl)cc(Cl)c1)C(F)(F)F)c1ccc(CN2C(=O)c3ccccc3C2=O)c(Br)c1>>O=C(CC(C[N+](=O)[O-])(c1cc(Cl)cc(Cl)c1)C(F)(F)F)c1ccc(CN2C(=O)c3ccccc3C2=O)c(Br)c1,,CC#N,,C1CCC2=NCCCN2CC1,O,val
US20040002524A1,COc1ccc(Nc2ccccc2N)c(C)c1.Cc1ccccc1C(=O)O>>COc1ccc(Nc2ccccc2NC(=O)c2ccccc2C)c(C)c1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US20160159804A1,C=CC(=O)Cl.c1ccc(Oc2ccc(Oc3ncnc4ccn(C5CNC5)c34)cc2)cc1>>C=CC(=O)N1CC(n2ccc3ncnc(Oc4ccc(Oc5ccccc5)cc4)c32)C1,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20060047127A1,O=C(O)C(=O)O.c1ccc(-n2ncc3c2CCCC3CCN2CCOCC2)cc1>>O=C(O)C(=O)O.c1ccc(-n2ncc3c2CCCC3CCN2CCOCC2)cc1,,CC(C)=O,,O,O,val
US20140135304A1,O=[N+]([O-])c1ccc(OC2CCN(C3CCC3)CC2)cc1>>Nc1ccc(OC2CCN(C3CCC3)CC2)cc1,[Pd],CO,,[H][H],,val
US20120270857A1,COC(=O)c1cccc2[nH]nc(C=O)c12.COc1ccc(CBr)cc1>>COC(=O)c1cccc2c1c(C=O)nn2Cc1ccc(OC)cc1,,CN(C)C=O,,[I-].[Na+],O=C([O-])[O-].[Cs+].[Cs+],val
US20030130213A1,N.N#Cc1nc(F)cnc1F>>N#Cc1nc(F)cnc1N,,C1COCCO1,,O,,val
US20140171316A1,CNC(=O)c1cc(-n2cncn2)cc(C)c1N.O=C(Cl)c1cnn(CC(F)(F)F)c1-c1ncccc1Cl>>CNC(=O)c1cc(-n2cncn2)cc(C)c1NC(=O)c1cnn(CC(F)(F)F)c1-c1ncccc1Cl,,c1ccncc1,,,,val
US20040132726A1,CCOC(=O)N1CCNCC1.Cc1ccc(Cl)c(-c2nc(CCl)no2)c1>>CCOC(=O)N1CCN(Cc2noc(-c3cc(C)ccc3Cl)n2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US06303818B1,CC(C)=O.O=Cc1c(Cl)ccc(Cl)c1Cl>>CC(=O)/C=C/c1c(Cl)ccc(Cl)c1Cl,,O,,[Na+].[OH-],,val
US05688795,COc1ccccc1N1CCNCC1.OCCCBr>>COc1ccccc1N1CCN(CCCO)CC1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20110046127A1,CCOC(=O)c1cnc2ccc(Cl)nn12.Nc1ccccc1>>O=C(Nc1ccccc1)c1cnc2ccc(Cl)nn12,,ClCCl,,C[Al](C)C,,val
US20100222431A1,CC(C)c1cccc(C(C)C)c1N=C=O.NCC1(S(=O)(=O)c2ccccc2)CCCC1>>CC(C)c1cccc(C(C)C)c1NC(=O)NCC1(S(=O)(=O)c2ccccc2)CCCC1,,ClCCl,,,,val
US20130129677A1,Cc1ccc(OS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1>>Cc1ccc(OS(=O)(=O)c2ccc(N)cc2)cc1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20090286778A1,C1=COCCC1.O=[N+]([O-])c1cccc(O)c1>>O=[N+]([O-])c1cccc(OC2CCCCO2)c1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20020183320A1,CC(=O)Cl.Nc1nccs1.O=Cc1ccccc1.[C-]#[N+]C(C)(C)C>>CC(=O)N(c1c(-c2ccccc2)nc2sccn12)C(C)(C)C,,[O-][Cl+3]([O-])([O-])O,,,,val
US20110257196A1,COc1cc(C(=O)c2cn(S(=O)(=O)c3ccccc3)c(-c3cn(S(=O)(=O)c4ccccc4)c4ccccc34)n2)cc(OC)c1OC>>COc1cc(C(=O)c2c[nH]c(-c3c[nH]c4ccccc34)n2)cc(OC)c1OC,,CCO,O,[Na+].[OH-],,val
US20110118245A1,CC(C)(CO)c1cc(NC(=O)Oc2ccccc2)no1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CC(C)(COS(=O)(=O)c1ccc([N+](=O)[O-])cc1)c1cc(NC(=O)Oc2ccccc2)no1,,ClCCl,,c1ccncc1,,val
US20090286812A1,CC(C)(C)OC(=O)N1CCC(n2ncc3c(Cl)ncnc32)CC1.Oc1ccc(Cl)c(C(F)(F)F)c1>>CC(C)(C)OC(=O)N1CCC(n2ncc3c(Oc4ccc(Cl)c(C(F)(F)F)c4)ncnc32)CC1,,CN(C)C=O,,,,val
US20100252433A1,CCCc1c[nH]c(C=O)c1.CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCc1c[nH]c(/C=C/C(=O)OCC)c1,,c1ccccc1,,,,val
US20110257100A1,CN1CCNCC1.O=C(Cl)c1cc2nccc(Cl)c2s1>>CN1CCN(C(=O)c2cc3nccc(Cl)c3s2)CC1,,ClCCl,O,CCN(CC)CC,,val
US20070129369A1,CN(C)C1(c2cccc(F)c2)CCC(N)CC1.Cc1onc(-c2ccccc2Cl)c1C(=O)Cl>>Cc1onc(-c2ccccc2Cl)c1C(=O)NC1CCC(c2cccc(F)c2)(N(C)C)CC1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,[Na+].[OH-],val
US06063789,Cl.NC1=NC(c2ccncc2)Cc2ccccc21>>Cl.NC1=NC(C2CCNCC2)Cc2ccccc21,O=[Pt],CO,Cl,[H][H],,val
US20130053397A1,CC(C)=O.CCOC(=O)C1CCC1>>CC(=O)CC(=O)C1CCC1,,CCOCC,,,,val
US20150011551A1,COc1ccc(Cl)cc1S(=O)(=O)Cl.Nc1cnc2ccccc2c1>>COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2ccccc2c1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20110224168A1,OC[C@H]1O[C@@H]2O[C@@H]3[C@@H](CO)O[C@H](O[C@@H]4[C@@H](CO)O[C@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@@H]6[C@@H](CO)O[C@H](O[C@@H]7[C@@H](CO)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)O[C@@H]5CO)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O>>OC[C@H]1O[C@@H]2O[C@@H]3[C@@H](CO)O[C@H](O[C@@H]4[C@@H](CO)O[C@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@@H]6[C@@H](CO)O[C@H](O[C@@H]7[C@@H](CO)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)O[C@@H]5CO)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O,,O,,,,val
US09181186B2,CO.COC(=O)c1cc(OCC(C)C)c(-c2cc(OC)ccc2F)nc1Cl>>COC(=O)c1cc(OCC(C)C)c(-c2cc(OC)ccc2F)nc1OC,,C1CCOC1,CO,Cl,C[O-].[Na+],val
US20010027196A1,NCCc1ccc(O)cc1.Nc1nc(OS(=O)(=O)C(F)(F)F)c(F)c(-c2ccco2)n1>>Nc1nc(NCCc2ccc(O)cc2)c(F)c(-c2ccco2)n1,,COCCOC,,,,val
US05434150,CCP(=O)(C#N)CC.COC(=O)CCNC(=O)c1ccc2c(c1)nc(-c1ccc(C(=N)N)cc1)n2CCCCc1ccccc1>>CCP(=O)(CC)NC(=N)c1ccc(-c2nc3cc(C(=O)NCCC(=O)OC)ccc3n2CCCCc2ccccc2)cc1,,CN(C)C=O,,,,val
US20080269196A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1ccc(CNC2CCCCC2)cc1>>CC(C)(C)OC(=O)N(Cc1ccc(C#N)cc1)C1CCCCC1,,ClCCl,,CCN(CC)CC,,val
US20150266862A1,CC1(C(=O)O)CCNC1.CO>>COC(=O)C1(C)CCNC1,,CO,,C[Si](C)(C)Cl,,val
US20100113462A1,CC(C)=CB1OC(C)(C)C(C)(C)O1.CCOC(=O)C1(NC(=O)c2cccc(C(F)(F)F)c2I)Cc2ccccc2C1>>CCOC(=O)C1(NC(=O)c2cccc(C(F)(F)F)c2C=C(C)C)Cc2ccccc2C1,,C1COCCO1,,N#N,O=C([O-])[O-].[K+].[K+],val
US20140045828A1,COCOc1ccc(Br)cc1[C@](COCC#N)(N[S@@](=O)C(C)(C)C)c1cc(N2CCOCC2)nc(F)c1Cl>>NC1=N[C@@](c2cc(Br)ccc2O)(c2cc(N3CCOCC3)nc(F)c2Cl)COC1,,C1CCOC1,,Cl,,val
US05608109,C#CCSCC(=NNC(=O)Nc1ccc(OC(F)(F)F)cc1)c1ccccc1>>C#CCSCC(NNC(=O)Nc1ccc(OC(F)(F)F)cc1)c1ccccc1,,CO,,Cl,[BH3-]C#N.[Na+],val
US20040082583A1,CNc1cc(Oc2ccc(N)cc2)ccc1[N+](=O)[O-].COC(=O)N=C(NC(=O)OC)SC>>COC(=O)Nc1nc2ccc(Oc3ccc(N)cc3)cc2n1C,[Pd],CO,,CC(=O)O,,val
US06093753,COS(=O)(=O)OC.F[P-](F)(F)(F)(F)F.O=C(CSCC(=O)OCCc1ccc2ccccc2c1)OCCc1ccc2ccccc2c1>>C[SH+]CC(=O)OCCc1ccc2ccccc2c1.F[P-](F)(F)(F)(F)F,,CCOC(C)=O,,O,,val
US20100048543A1,NCc1cncnc1N1CCOCC1.Nc1ncc(C#Cc2cccc(NC(=O)Oc3ccccc3)c2)cn1>>Nc1ncc(C#Cc2cccc(NC(=O)NCc3cncnc3N3CCOCC3)c2)cn1,,C1CCOC1,,CCN(CC)CC,,val
US20150191465A1,Cc1nc(N)nc(N[C@@H](C)c2nc3ccn(C)c3cc2N(C)C2CN(C(=O)OC(C)(C)C)C2)c1C#N.O=C(O)C(F)(F)F>>Cc1nc(N)nc(N[C@@H](C)c2nc3ccn(C)c3cc2N(C)C2CNC2)c1C#N.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20040204397A1,COC(=O)C(N)Cc1ccc(OC)nc1.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O.O=C1Nc2ccccc2CN1C1CCNCC1>>COC(=O)C(Cc1ccc(OC)nc1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110245224A1,C[C@H]1CN(c2c(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc3c(-c4n[nH]c(=O)o4)noc3c2F)C[C@@H](C)O1>>C[C@H]1CN(c2c(CO)cc3c(-c4n[nH]c(=O)o4)noc3c2F)C[C@@H](C)O1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140206681A1,COC(=O)[C@H]1CC[C@@H]2CCC(=O)N2C1>>O=C(O)[C@H]1CC[C@@H]2CCC(=O)N2C1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20100168082A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCc1cc(Oc2ccc3[nH]c(C)cc3c2F)ncn1>>Cc1cc2c(F)c(Oc3cc(CN(C)C(=O)OC(C)(C)C)ncn3)ccc2[nH]1,,C1CCOC1,CCOC(C)=O,O,O=C([O-])O.[Na+],val
US04562292,O=C(NC(=O)C(F)(F)F)C(F)(F)F.Sc1ccccc1>>O=C(Cc1cccs1)C(F)(F)F,,ClC(Cl)(Cl)Cl,,,,val
US20100120798A1,CN(C)CC1(c2cccc(-c3cnn(C)c3)c2)CCN(C(=O)OC(C)(C)C)CC1>>CN(C)CC1(c2cccc(-c3cnn(C)c3)c2)CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06350749B1,CC(=O)CCl.O=C1CC(=O)CC(c2cccc(Cl)c2Cl)C1>>Cc1coc2c1C(=O)CC(c1cccc(Cl)c1Cl)C2,,CCO,CN(C)C=O,C,C[O-].[Na+],val
US06375926B1,NCc1ccc(C(=O)OCc2ccccc2)cc1.O=C(Cl)Cl>>O=C=NCc1ccc(C(=O)OCc2ccccc2)cc1,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US20130023664A1,Cc1ccc(N)c(C(=O)OC(C)(C)C)n1.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(N)c(C(=O)OC(C)(C)C)[n+]1[O-],,ClC(Cl)Cl,,O,[Na+].[OH-],val
US20120149676A1,CC(C)(C)OC(=O)NCc1ccc(Cl)c(N)c1Cl.O=c1ccccn1C(=S)n1ccccc1=O>>CC(C)(C)OC(=O)NCc1ccc(Cl)c(N=C=S)c1Cl,,C1COCCO1,,,,val
US20050032871A1,Cc1ccc(S(=O)(=O)c2c(C)[nH]c(C=O)c2CCC(=O)O)cc1.O=C1Cc2ccc(Br)cc2N1>>Cc1ccc(S(=O)(=O)c2c(C)[nH]c(/C=C3\C(=O)Nc4cc(Br)ccc43)c2CCC(=O)O)cc1,,CCO,,C1CCNCC1,,val
US20150031733A1,CCOc1cccc(N)c1C.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCOc1cccc(N=C=O)c1C,,Cc1ccccc1,,,,val
US05438052,CC(C)(ON)C(=O)NO.Nc1nc(C(=O)C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(CSc4ncncc4-c4ccc(O)c(O)c4)CS[C@H]23)cs1>>CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3ncncc3-c3ccc(O)c(O)c3)CS[C@H]12)c1csc(N)n1)C(=O)NO,,CC(=O)N(C)C,,Cl,,val
US05213606,CCOC(=O)C(C)Oc1ccc(Oc2ncc(Cl)cc2Cl)cc1>>CC(Oc1ccc(Oc2ncc(Cl)cc2Cl)cc1)C(=O)O,,C1CCOC1,,[Na+].[OH-],,val
US03995052,CC(=O)CI.OCCC1=CCc2ccccc21>>CC1(CI)OCCC2=C1Cc1ccccc12,,c1ccccc1,,CCOCC,FB(F)F,val
US20160007606A1,COC(=O)C1CN(c2nc(C3=NOC(c4c(F)cccc4F)C3)cs2)CCN1C(=O)Cn1nc(C(F)(F)F)cc1C>>Cc1cc(C(F)(F)F)nn1CC(=O)N1CCN(c2nc(C3=NOC(c4c(F)cccc4F)C3)cs2)CC1C(=O)O,,C1CCOC1,,[Na+].[OH-],,val
US06762201B1,CC(C(=O)NCc1c(N)ccc(C(=O)O)c1C(C)(C)C)C1CCCC1.O=C(O)C(F)(F)F>>CC(C(=O)NCc1cc(C(=O)O)ccc1N)C1CCCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20020103247A1,BrCCCCBr.CC(C)(C)OC(=O)N1CCc2cc(O)ccc21>>CC(C)(C)OC(=O)N1CCc2cc(OCCCCBr)ccc21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCc3nnco3)CC2)c2ncnn12.CS(C)=O.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](OCc3n[nH]c(=O)o3)CC2)c2ncnn12,,CCOC(C)=O,O,[Cl-].[Na+],,val
US20100184761A1,CC(=O)Nc1cccc(CCl)c1.Cn1cnc2c(C#N)nc(-c3ccc(O)c(C(F)(F)F)c3)cc21>>CC(=O)Nc1cccc(COc2ccc(-c3cc4[nH]cnc4c(C#N)n3)cc2C(F)(F)F)c1,,CC#N,O,[I-].[K+],O=C([O-])O.[Na+],val
US20030180662A1,C=CC(=O)Cl.OCC12CC3CC(CC(O)(C3)C1)C2>>C=CC(=O)OCC12CC3CC(CC(O)(C3)C1)C2,,C1COCCO1,,CCN(CC)CC,,val
US06143764,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.ClCCCNc1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)NCCCCl)cc3)c2cc1OC,,CCN(CC)CC,Cc1ccccc1,O=C([O-])O.[Na+],,val
US20120046308A1,CCCCc1nc(C)n(-c2ncc(O)cn2)c(=O)c1Cc1cc(CCC)c(O[Si](C)(C)C(C)(C)C)c(CCC)c1.CCOC(=O)CCCBr>>CCCCc1nc(C)n(-c2ncc(OC(C)CC(=O)OCC)cn2)c(=O)c1Cc1cc(CCC)c(O[Si](C)(C)C(C)(C)C)c(CCC)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130072467A1,CO[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N(C)C>>CO[C@H](C)[C@H](N)C(=O)N(C)C,,CCOC(C)=O,,Cl,,val
US20130116245A1,CC1(C)Cc2sc(C(=O)NC(C)(C)C)c(C=O)c2C1.NN>>CC1(C)Cc2sc(C(=O)NC(C)(C)C)c(C=NN)c2C1,,C1CCOC1,,,,val
US04719049,COCCO.O=Cc1c2ccccc2c(Cl)c2ccccc12>>COCCOc1c2ccccc2c(C=O)c2ccccc12,,O,,CC(C)(C)[O-].[K+],,val
US05403934,CN.Cc1cc(=O)c(-c2ccc(Cl)cc2)c(C)o1>>Cc1cc(=O)c(-c2ccc(Cl)cc2)c(C)n1C,,CCO,,,,val
US20130178460A1,Nc1ccc2cnccc2n1.O=C(O)c1csc2cnc(Cl)nc12>>O=C(Nc1ccc2cnccc2n1)c1csc2cnc(Cl)nc12,,CCOC(C)=O,c1ccncc1,O=P(Cl)(Cl)Cl,,val
US20120165370A1,Cc1ccc2cccc(O)c2n1>>c1ccc2ncccc2c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20030187068A1,CCOC(=O)CC(=O)c1cc(CC(CC)C(=O)OCC)ccc1OC.FC(F)(F)c1ccc(CBr)cc1>>CCOC(=O)C(CC)Cc1ccc(OC)c(C(=O)C(Cc2ccc(C(F)(F)F)cc2)C(=O)OCC)c1,,C1CCOC1,,Cl,[H-].[Na+],val
US20110263599A1,COC(=O)c1c(Br)c2c(-c3ccccc3C)cccc2n1CCCOc1cccc2ccccc12.N#C[Zn]C#N>>COC(=O)c1c(C#N)c2c(-c3ccccc3C)cccc2n1CCCOc1cccc2ccccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20100197674A1,CCOC(=O)c1nc2ccccc2n(C)c1=O>>Cn1c(=O)c(C(=O)O)nc2ccccc21,,CCO,,[Na+].[OH-],,val
US06448270B1,Cc1cccc(C#CCCS(C)(=O)=O)c1.c1ccc(CC2CCNCC2)cc1>>Cc1cccc(C#CCCN2CCC(Cc3ccccc3)CC2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US06599917B1,Ic1ccc(N2CCC3(C2)OCCO3)nc1Cc1ccccc1.O=C1CCC(=O)N1Cl>>Clc1cc(I)c(Cc2ccccc2)nc1N1CCC2(C1)OCCO2,,CN(C)C=O,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US06770785B1,CC(C)(C)c1cc(CBr)cc(C(C)(C)C)c1O.Cc1cc(N)c(C)cc1N>>Cc1cc(Nc2ccc(C(C)(C)C)c(O)c2C(C)(C)C)c(C)cc1N,,C1CCOC1,,,,val
US20150291554A1,C=CC(=O)O.NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn([C@@H]2CCCNC2)c1N>>C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2N)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US04508727,CCCCCCCC[C@H](N[C@@H](C)C(=O)N1C(=O)N(Cc2ccccc2)C[C@H]1C(=O)OCc1ccccc1)C(=O)OCc1ccccc1>>CCCCCCCC[C@H](N[C@@H](C)C(=O)N1C(=O)N(Cc2ccccc2)C[C@H]1C(=O)O)C(=O)O,[Pd],,,,,val
US20050277670A1,CC(C)(C)OC(=O)N1CCC(C(O)c2ccc(Br)cc2)CC1.Oc1ccccc1>>CC(C)(C)OC(=O)N1CCC(C(Oc2ccccc2)c2ccc(Br)cc2)CC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030073849A1,CON(C)C(=O)C1CC1c1csc2ccccc12>>O=C[C@@H]1C[C@H]1c1csc2ccccc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090029975A1,CCOC(=O)C=Cc1cc(Cl)ccn1>>CCOC(=O)CCc1cc(Cl)ccn1,[Ni],CCO,,,,val
US20070088041A1,CCCC=Cc1c(-c2cc(-c3ccncc3)nnc2OC)[nH]c2ccccc12>>CCCCCc1c(-c2cc(-c3ccncc3)nnc2OC)[nH]c2ccccc12,[Pd],CCO,,,,val
US20140045862A1,COCCOCCl.c1cn[nH]c1>>COCCOCn1cccn1,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20080021032A1,CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(CCC(=O)O)n2)cc1Cl.Cc1ccc(S(=O)(=O)Cl)cc1.O>>Cc1ccc(S(=O)(=O)OC[C@H]2CCCO2)cc1,,ClCCl,,CCN(CC)CC,,val
US08268834B2,CON(C)C(=O)c1nccnc1N.Clc1ccc([Mg]Br)cc1>>Nc1nccnc1C(=O)c1ccc(Cl)cc1,,C1CCOC1,,Cc1ccccc1,Cl,val
US20110098296A1,CC(C)O.CN(C(=O)c1cc(F)ccc1F)c1cccc(-c2nc(N)sc2-c2ccnc(Cl)n2)c1.Nc1cccc(CN2CCCC2)c1>>CN(C)C1Cc2ccc(N)cc2C1,Cl,CC(C)O,,,,val
US20100179139A1,CC(C)(C)OC(=O)NCCNS(=O)(=O)c1ccc(Cl)nc1.OB(O)c1ccnc2[nH]c(C(F)(F)F)cc12>>CC(C)(C)OC(=O)NCCNS(=O)(=O)c1ccc(-c2ccnc3[nH]c(C(F)(F)F)cc23)nc1,,ClCCl,O,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US06313116B1,COc1ccc(C(=O)O)c2sc(N3CCCCC3)nc12.Cc1noc(C)c1N>>COc1ccc(C(=O)Nc2c(C)noc2C)c2sc(N3CCCCC3)nc12,CN(C)C=O,CCN(CC)CC,ClCCl,O=C(Cl)C(=O)Cl,,val
US20150031668A1,CCOC(=O)c1nc(C(=O)O)c[nH]1.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.N[C@]1(c2ccc(OC(F)(F)F)c(F)c2)CCOc2cccnc21>>CCOC(=O)c1ncc(C(=O)N[C@]2(c3ccc(OC(F)(F)F)c(F)c3)CCOc3cccnc32)[nH]1.O=C(O)C(F)(F)F,,CCOC(C)=O,O,CN(C)C=O,Cl,val
US20060089393A1,Cc1ccc(NC(=O)c2ccoc2)cc1B1OC(C)(C)C(C)(C)O1.Cc1nnc(-c2ccc(I)cc2)o1>>Cc1nnc(-c2ccc(-c3cc(NC(=O)c4ccoc4)ccc3C)cc2)o1,,CC(C)O,,,,val
US20110319380A1,CCI.O=c1c2ccc(Br)cc2nc2n1CCNCC2>>CCN1CCc2nc3cc(Br)ccc3c(=O)n2CC1,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20150166548A1,CNC.O=Cc1cscn1>>CN(C)Cc1cscn1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120270870A1,CS(=O)(=O)Cl.OCc1ccnc(Br)c1>>CS(=O)(=O)OCc1ccnc(Br)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06060468,Clc1cc(Cl)c2c(c1)CC(Cl)c1ccccc1S2.OCCBr>>Clc1cc(Cl)c2c(c1)CC(OCCBr)c1ccccc1S2,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20090111796A1,CCC(=O)c1ccc(F)cc1.COc1ccc(CS)cc1>>CCC(=O)c1ccc(SCc2ccc(OC)cc2)cc1,,CN(C)C=O,,[Na+].[OH-],,val
US20060166990A1,CCN=C=O.Cc1ccc(N)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl>>CCNC(=O)Nc1ccc(C)c(C(=O)c2ccc(Nc3ccc(F)cc3F)cc2Cl)c1,,C1COCCO1,,,,val
US20020107278A1,c1ccc(CN2CCc3[nH]c4cccc(N=C(c5ccccc5)c5ccccc5)c4c3CC2)cc1>>Nc1cccc2[nH]c3c(c12)CCN(Cc1ccccc1)CC3,,C1CCOC1,,Cl,,val
US05488172,CC(C)=CCC/C(C)=C/CO>>CC(C)=CCC[C@H](C)CCO,,CO,,O=O,,val
US20090124682A1,CC(OC[C@@H]1c2ccccc2C[C@H]1N)C(=O)OC(C)(C)C.O=C(O)c1cc2cc(Cl)ccc2[nH]1>>CC(OC[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)OC(C)(C)C,,CC(=O)N(C)C,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20140051672A1,COB(OC)OC.FC(F)(F)Oc1cc(OCc2ccccc2)ccc1Br>>OB(O)c1ccc(OCc2ccccc2)cc1OC(F)(F)F,,C1CCOC1,,[Li]CCCC,,val
US04528194,O=C(CBr)c1ccc(O)cc1.c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>O=C(CN1CCN(C(c2ccccc2)c2ccccc2)CC1)c1ccc(O)cc1,,CC(C)O,,CCN(CC)CC,,val
US20110142796A1,CCOC1(O[Si](C)(C)C)CC1.c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2cn1>>c1cc2c3cnc(Nc4ccc(N5CCN(C6CC6)CC5)cn4)nc3n(C3CCCC3)c2cn1,,C1CCOC1,CC(=O)O,O,[BH3-]C#N.[Na+],val
US20100249402A1,CC(Br)C(=O)c1ccc(OCCCCCOc2ccc(C#N)cc2)cc1.CC(N)=S>>Cc1nc(-c2ccc(OCCCCCOc3ccc(C#N)cc3)cc2)c(C)s1,,CCOC(C)=O,,CCO,,val
US20050222171A1,COC(OC)N(C)C.N#CCc1cccc([N+](=O)[O-])c1>>CN(C)/C=C(\C#N)c1cccc([N+](=O)[O-])c1,,Cc1ccccc1C,,CCCCCC,,val
US04902701,CC(=O)OCCOc1ccc2oc3cc(-c4nnn[nH]4)ccc3c(=O)c2c1>>O=c1c2ccc(-c3nnn[nH]3)cc2oc2ccc(OCCO)cc12,,O,,Cl,[Na+].[OH-],val
US20060178374A1,COc1cc(OC)c(COc2ccc(Cl)c(C(C)Oc3cc(-c4ccc(C(=O)N5CCN(C(=O)OC(C)(C)C)CC5)cc4)cnc3N)c2Cl)c(OC)c1>>CC(Oc1cc(-c2ccc(C(=O)N3CCNCC3)cc2)cnc1N)c1c(Cl)ccc(O)c1Cl,,Cc1ccccc1,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20150126488A1,CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CCOC)cc2C(F)(F)F)CC1.Cl>>CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CCOC)cc2C(F)(F)F)CC1.Cl,,CCOC(C)=O,ClCCl,,,val
US20040058970A1,Cc1onc(-c2ccccc2)c1-c1nnc2n1Cc1ccc(O)cc1-2.OCc1cccnc1>>Cc1onc(-c2ccccc2)c1-c1nnc2n1Cc1ccc(OCc3cccnc3)cc1-2,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110201593A1,CN1Nc2cnc3c(ccn3S(=O)(=O)c3ccccc3)c2N1C1(C)CCN(C(=O)OC(C)(C)C)CC1>>CC1(n2nnc3cnc4c(ccn4S(=O)(=O)c4ccccc4)c32)CCNCC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20130102576A1,COC(=O)CN1C(=O)C2(OCC(C)(C)CO2)c2cc([N+](=O)[O-])ccc21>>COC(=O)CN1C(=O)C2(OCC(C)(C)CO2)c2cc(N)ccc21,[Pd],CCOC(C)=O,CO,,,val
US20030082510A1,CC(=O)Oc1ccc2c(C)c(CN3C(=O)c4ccccc4C3=O)c(=O)oc2c1C>>Cc1c(CN2C(=O)c3ccccc3C2=O)c(=O)oc2c(C)c(O)ccc12,,CO,,O=S(=O)(O)O,,val
US09006268B2,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.Fc1ccc(-c2nc(-c3ccccn3)c(Br)o2)cc1>>CC(C)(C)OC(=O)N1CC=C(c2oc(-c3ccc(F)cc3)nc2-c2ccccn2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20030125346A1,CC(C)(C)c1cc(N)no1.ClC1N=CC=CN1Cl>>CC(C)(C)c1cc(Nc2ccnc(Cl)n2)no1,,CN(C)C=O,,[H-].[Na+],,val
US20080318963A1,CCOC(=O)Cl.COc1nc2cc(F)ccc2nc1N>>CCOC(=O)Nc1nc2ccc(F)cc2nc1OC,,ClCCl,,c1ccncc1,,val
US20140228386A1,FC(F)(F)c1cc(I)cc(Cl)n1.O=C1NCCN1c1cnccc1C1CC1>>O=C1N(c2cc(Cl)nc(C(F)(F)F)c2)CCN1c1cnccc1C1CC1,I[Cu]I,C1COCCO1,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20100273739A1,O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2c(c1)C(Cc1cccc(Cl)c1)C(N1CCCC1)CC2>>O=S(=O)(Oc1ccc2c(c1)C(Cc1cccc(Cl)c1)C(N1CCCC1)CC2)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20080261965A1,CCOC(=O)c1cnc(C(C)(C)C)nc1O.O=P(Cl)(Cl)Cl>>CCOC(=O)c1cnc(C(C)(C)C)nc1Cl,,CCN(CC)CC,,,,val
US04424229,CN(C=O)c1ccccc1.Fc1cc(F)cc([Mg]Br)c1>>O=Cc1cc(F)cc(F)c1,,C1CCOC1,CCOCC,,,val
US05942516,BrC(Br)(Br)Br.OCc1ccccc1CO>>OCc1ccccc1CBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05100577,COC(Cl)Cl.Cc1ccc(S(=O)(=O)Oc2ccc(-c3ccccc3)cc2)cc1>>Cc1ccc(S(=O)(=O)Oc2ccc(-c3ccc(C=O)cc3)cc2)cc1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20040127493A1,BrCC1CO1.Nc1c(O)cccc1[N+](=O)[O-]>>Nc1c(OCC2CO2)cccc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04250183,CCOC(=O)CCCNCc1ccccc1.CSCC[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)O>>CSCC[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)N(CCCC(=O)O)Cc1ccccc1,,CCO,,[K+].[OH-],,val
US20020133007A1,O=C1C2C=CCCC2C(=O)N1c1c(F)cc(Cl)c(O)c1[N+](=O)[O-]>>Nc1c(O)c(Cl)cc(F)c1N1C(=O)C2C=CCCC2C1=O,[Fe],CC(=O)O,CCOC(C)=O,,,val
US05714489,CCOC(=O)CN(C(=O)C(=O)OCC)c1ccc(Cl)cc1[N+](=O)[O-]>>CCOC(=O)Cn1c(=O)c(=O)[nH]c2cc(Cl)ccc21,[Fe],CC(=O)O,,Cl,,val
US04001252,BrCc1ccccc1.CCOC(=O)C1=C(C)NC(N)=C(C(=O)OCC)C1c1cccc([N+](=O)[O-])c1>>CCOC(=O)C1=C(C)N=C(N)C(Cc2ccccc2)(C(=O)OCC)C1c1cccc([N+](=O)[O-])c1,,CCO,,C,C[O-].[Na+],val
US20100305096A1,CCOC(=O)C(C(=O)OCC)C1CCN(C(=O)OC(C)(C)C)CC1>>CC(C)(C)OC(=O)N1CCC(C(CO)CO)CC1,,C1CCOC1,Cc1ccccc1,Cl,[BH4-].[Li+],val
US04559402,CCCl.Cc1nn2ccccc2c1C(=O)C1=CNCCC1>>CCN1C=C(C(=O)c2c(C)nn3ccccc23)CCC1,,CN(C)C=O,,[H-].[Na+],,val
US04521325,CC(C)(C)NN.CN=C=O>>CNC(=O)N(N)C(C)(C)C,,C1CCOC1,ClC(Cl)Cl,Cl,[K+].[OH-],val
US20090264431A1,CC(C)(C)OC(=O)N1C[C@H](NS(=O)(=O)c2cc(Br)ccc2Br)C[C@@H]1CN.O=C(Cl)c1ccccc1>>CC(C)(C)OC(=O)N1C[C@H](NS(=O)(=O)c2cc(Br)ccc2Br)C[C@@H]1CNC(=O)c1ccccc1,,ClCCl,,,,val
US20150182537A1,O.O=C1OCCC1Oc1ccccc1>>O=C(O)C(CCO)Oc1ccccc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20040142933A1,CC(C)=O.O=C1Cc2cc(CCCCl)ccc2N1.O=CN1CCNCC1.c1ccc2[nH]ncc2c1>>CC(C)=C1C(=O)Nc2ccc(CCCN3CCN(c4n[nH]c5ccccc45)CC3)cc21,,CCOC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100009991A1,O=c1ccc(C(c2ccccc2)c2ccccc2)cn1CCCc1cccc(O)c1>>O=C1CCC(C(c2ccccc2)c2ccccc2)CN1CCCc1cccc(O)c1,O=[Pt]=O,CCO,,,,val
US20120142717A1,C=Cc1cc(F)c(Oc2cnc(C(F)(F)F)nc2)c(F)c1.OO>>OCCc1cc(F)c(Oc2cnc(C(F)(F)F)nc2)c(F)c1,,C1CCOC1,,B1C2CCCC1CCC2,[Na+].[OH-],val
US05102667,COc1ccc(OC)c(CC(=O)O)c1.O=C1CCC(c2ccccc2)(c2ccccc2)C2CNCC12>>COc1ccc(OC)c(CC(=O)N2CC3C(=O)CCC(c4ccccc4)(c4ccccc4)C3C2)c1,,ClCCl,,CCN(CC)CC,Cl,val
US20100240658A1,COC(=O)c1ccc(-c2noc(-c3ccc(N(C)C)c(N)c3)n2)cc1F.CS(=O)(=O)Cl>>COC(=O)c1ccc(-c2noc(-c3ccc(N(C)C)c(NS(C)(=O)=O)c3)n2)cc1F,,c1ccncc1,,,,val
US20100279970A1,NC1(Cl)N=C(Cl)N=C2C1=NCN2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O.NC1CCCCC1>>OC[C@H]1O[C@@H](n2cnc3c(NC4CCCCC4)nc(Cl)nc32)[C@H](O)[C@@H]1O,,CCO,,,,val
US20150105317A1,[N-]=[N+]=NCCO[C@H]1O[C@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@@H](OC(=O)c2ccccc2)[C@H](O[C@H]2O[C@H](COC(=O)c3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@H](OC(=O)c3ccccc3)[C@@H]2OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1>>[N-]=[N+]=NCCO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccccc2)[C@H](O[C@H]2O[C@H](COC(=O)c3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@H](OC(=O)c3ccccc3)[C@@H]2OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070112063A1,CC(=O)c1ccc(Cl)cc1O.CC(C)=O>>CC1(C)CC(=O)c2ccc(Cl)cc2O1,,CO,,C1CCNC1,,val
US20130143863A1,COC(=O)c1ccc(Cl)nc1CCl.COc1ccc(CN)cc1>>COc1ccc(CN2Cc3nc(Cl)ccc3C2=O)cc1,,C1CCOC1,,,,val
US04410537,CCOC(=O)CCCCBr.COc1cccc(O)c1C=O>>COc1cccc(OCCCCC(=O)O)c1C=O,,CCO,,[I-].[K+],O=C([O-])O.[Na+],val
US20100173968A1,C=CCC(C(=O)OCC)C(=O)OCC.O=C1CCC(=O)N1I>>C=CCC(I)(C(=O)OCC)C(=O)OCC,,C1CCOC1,CCOCC,[H-].[Na+],,val
US20070123573A1,BrBr.O=C1CCC(N2C(=O)c3ccccc3C2=O)CC1>>O=C1CCC(N2C(=O)c3ccccc3C2=O)C(Br)C1,,CCOC(C)=O,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04338333,CC(=O)Cc1ccc(OCc2ccccc2)cc1.OCCO>>CC1(Cc2ccc(OCc3ccccc3)cc2)OCCO1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US06140333,[N-]=[N+]=NCC=C1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1>>NCC=C1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120252792A1,O=C(O)C1CC(=O)N(c2ccc(Cl)cc2)C1.OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>O=C(NC1CC(=O)N(c2ccc(Cl)cc2)C1)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US04066772,O.O=C([O-])C(O)C(O)C(=O)[O-].O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1>>O.O=C(O)C(O)C(O)C(=O)O.O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1,,O,,C,,val
US20020137961A1,COCOc1ccc(C2CCC(=CC#N)CC2)c(OCOC)c1>>N#CC=C1CCC(c2ccc(O)cc2O)CC1,,CO,,Cl,O=C([O-])O.[Na+],val
US20060052392A1,CCOC(=O)CC1c2cc(C)c(C)cc2C(=O)N1c1ccc(F)cc1>>Cc1cc2c(cc1C)C(CCO)N(c1ccc(F)cc1)C2=O,,C1CCOC1,,O,[BH4-].[Li+],val
US20130237595A1,CCC(=O)c1c(O)cc(CCCC=O)oc1=O.COC(=O)CP(=O)(OC)OC>>CCC(=O)c1c(O)cc(CCC/C=C/C(=O)OC)oc1=O,,C1CCOC1,,[H-].[Na+],,val
US20150191452A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc(C2=CCNCC2)cc1F>>COc1ccc(C2=CCN(C(=O)OC(C)(C)C)CC2)cc1F,,ClCCl,O,CCN(CC)CC,Cl,val
US05292767,CC(C)(C)OC(=O)C(CO)C[C@H](O)CCl.CS(=O)(=O)Cl>>C=C(C[C@@H](CCl)OS(C)(=O)=O)C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20080125396A1,CCCCN1C(=O)C(Nc2ccc(OC(F)F)cc2)=C(c2ccccc2)S1(=O)=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCCCN1C(=S)C(Nc2ccc(OC(F)F)cc2)=C(c2ccccc2)S1(=O)=O,,Cc1ccccc1,,,,val
US05972975,CC(=O)CCC(C)=O.C[C@H](N)CO>>Cc1ccc(C)n1[C@@H](C)CO,,CO,,CCCCCC,CCOC(C)=O,val
US20130274241A1,C=O.O=[N+]([O-])c1cnn(C2CCNC2)c1>>CN1CCC(n2cc([N+](=O)[O-])cn2)C1,,O=CO,,Cl,,val
US06232310B1,CC(=O)Nc1ccc(F)cc1S(=O)(=O)CC#N>>CC1=C(C#N)S(=O)(=O)c2cc(F)ccc2N1,,[Na+],[OH-],,,val
US20080306059A1,CCOC(=O)C12CCC(c3ccccc3)(CC1)CC2.CNOC>>CON(C)C(=O)C12CCC(c3ccccc3)(CC1)CC2,,C1CCOC1,,CC(C)[Mg]Cl,Cl,val
US20150210722A1,CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)n(-c2ccc(P(C)(C)=O)cc2)n1.CNc1ccccc1>>CN(c1ccccc1)c1nccc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(P(C)(C)=O)cc3)c3ccccc23)n1,,C1CCOC1,,CN(C)C=O,,val
US20110294781A1,CC(C)c1cccc(C=O)c1.NNc1cc(N2CCOCC2)n2nc(-c3ccncc3)cc2n1>>CC(C)c1cccc(C=NNc2cc(N3CCOCC3)n3nc(-c4ccncc4)cc3n2)c1,,CCO,,,,val
US05593983,CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](N5CCOC(C)(C)C5)C[C@]4(C)[C@H]3CC[C@]12C.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](N5CCOC(C)(C)C5)C[C@]4(C)[C@H]3CC[C@]12C.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-],,CO,,,,val
US20140243310A1,C[C@@H](COc1cc(Cl)c(NC(=O)c2cc(F)c(OCC3CC3)cc2F)cn1)NC(=O)OC(C)(C)C>>C[C@@H](COc1cc2oc(-c3cc(F)c(OCC4CC4)cc3F)nc2cn1)NC(=O)OC(C)(C)C,[Cu]I,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20050043351A1,COC(=O)n1ncc2c(NC(=O)ON3C(=O)CCC3=O)cccc21.COCC(C)(C)c1ccc2c(c1)CCC2N>>COCC(C)(C)c1ccc2c(c1)CCC2NC(=O)Nc1cccc2c1cnn2C(=O)OC,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20040147580A1,CCOC(=O)c1cc2c(Cl)cc(Cl)cc2[nH]1.CI>>CCOC(=O)c1cc2c(Cl)cc(Cl)cc2n1C,,CN(C)C=O,,[H-].[Na+],,val
US20110212918A1,O=C(Nc1cnc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(Nc2ncccn2)c1)OCc1ccccc1>>Nc1cnc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(Nc2ncccn2)c1,[Pd],CO,,,,val
US20080261978A1,CC(C)(C)OC(=O)NCc1ccc(N)cc1.O=C=NCc1ccccc1>>CC(C)(C)OC(=O)NCc1ccc(NC(=O)NCc2ccccc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US04009200,CC(C)(C)C1=CC(=O)C=CC1=O.ClC1=C(Cl)C(Cl)(Cl)C(Cl)=C1Cl>>CC(C)(C)C1=CC(=O)C2C(C1=O)C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl,,Cc1ccccc1,,,,val
US20100266509A1,Cc1cc(C)c(S(=O)(=O)ON)c(C)c1.Nc1cccnc1>>Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1.Nc1ccc[n+](N)c1,,ClCCl,,O,,val
US20120309739A1,Cc1nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c(=O)n1CC(F)(F)F>>Cc1nc2oc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)c2c(=O)n1CC(F)(F)F,,ClCCl,,,,val
US20130072467A1,CC[C@H](C)[C@H](NC1=NC(=O)SC1)C(=O)N(C)C.O=CC1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1>>CC[C@H](C)[C@H](NC1=NC(=O)S/C1=C\C1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1)C(=O)N(C)C,,CC(C)O,,C1CC[NH2+]CC1.CC(=O)[O-],,val
US04873253,CC(C)(C)OC(=O)ON=C(C#N)c1ccccc1.NC(Cc1cccc(Oc2ccc(Br)cn2)c1)C(=O)O>>CC(C)(C)OC(=O)NC(Cc1cccc(Oc2ccc(Br)cn2)c1)C(=O)O,,C1COCCO1,O,CCN(CC)CC,CCOC(C)=O,val
US20120283239A1,CC(C)(C)OC(=O)N1CCC(CCO)CC1.Oc1ccc(Br)cc1C(F)(F)F>>CC(C)(C)OC(=O)N1CCC(CCOc2ccc(Br)cc2C(F)(F)F)CC1,,ClCCl,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140073620A1,NC(=O)C1(c2ccccc2CCc2nc(Cl)ncc2Cl)CC1.Nc1cnn(C(F)F)c1>>NC(=O)C1(c2ccccc2CCc2nc(Nc3cnn(C(F)F)c3)ncc2Cl)CC1,,C1COCCO1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20080171754A1,CC(C)(C)OC(=O)N1Cc2cccc(Br)c2C1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(C)(C)OC(=O)N1Cc2cccc(B3OC(C)(C)C(C)(C)O3)c2C1,,CCOC(C)=O,CN(C)C=O,CC(=O)[O-].[K+],,val
US20020010206A1,CCOC(=O)/C=C/C(F)(F)F.O=Cc1cc(I)ccc1O>>CCOC(=O)C1=Cc2cc(I)ccc2OC1C(F)(F)F,,CCOC(C)=O,,CCN(CC)CC,,val
US20080293775A1,COc1cc(CBr)cc(C(F)(F)F)c1.CSc1ccc(B(O)O)c(Cl)c1.O=C(OO)c1cccc(Cl)c1>>COc1cc(Cc2ccc(S(C)(=O)=O)cc2Cl)cc(C(F)(F)F)c1,,C1COCCO1,ClCCl,O,[Cs+].[F-],val
US20090048248A1,Cc1cc(F)ccc1[C@@H]1[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC[C@@H]2CNC[C@H]21.O=c1[nH]cc(Br)c(=O)[nH]1>>Cc1cc(F)ccc1[C@@H]1[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC[C@@H]2CN(c3c[nH]c(=O)[nH]c3=O)C[C@H]21,,c1ccncc1,,,,val
US20120202785A1,Cc1ccccc1-n1c([C@H](C)N)nc2cccnc21.Clc1ncnc2c1ncn2C1CCCCO1>>Cc1ccccc1-n1c(C(C)Nc2ncnc3[nH]cnc23)nc2cccnc21,,CCCCO,,CCN(C(C)C)C(C)C,,val
US04560700,CCOC(=O)c1[nH]c(C)c(C(=O)OCC)c1C>>CCOC(=O)c1c(C)[nH]c(C(=O)O)c1C,,CCO,O,[K+].[OH-],,val
US20140107246A1,O=C(O)/C=C/C(=O)O.O=C(O)CCCCCCCCC(=O)O.OCC(O)CO>>O=C(O)/C=C/C(=O)O.O=C(O)CCCCCCCCC(=O)O.OCC(O)CO,,O,,,,val
US20130281438A1,COc1cc([N+](=O)[O-])cc(OC)c1OC>>COc1cc(N)cc(OC)c1OC,[Pd],CCO,,NN,O,val
US20060178373A1,CC(C)(C)N.COc1cc(OC)cc(-c2cc(=O)c3ccc(OCC4CO4)cc3o2)c1>>COc1cc(OC)cc(-c2cc(=O)c3ccc(OCC(O)CNC(C)(C)C)cc3o2)c1,,CO,,,,val
US06156761,CC1CC(=O)c2c(O)ccc(Br)c2C1.CCCC[Sn](CCCC)(CCCC)c1nccs1>>CC1CC(=O)c2c(O)ccc(-c3nccs3)c2C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20090198057A1,CCOC=C(C(=O)OCC)C(=O)OCC.N=C(NO)c1ccc(F)c(F)c1>>CCOC(=O)c1cnc(-c2ccc(F)c(F)c2)nc1O,,CCO,,[Na],,val
US05538987,CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1>>CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1,,CCO,,CC(=O)O,[BH4-].[Na+],val
US20090105227A1,COC(=O)Cn1c(Br)c(C2CCCCC2)c2sc(C(=O)OC(C)(C)C)cc21.O=Cc1ccccc1B(O)O>>COC(=O)Cn1c(-c2ccccc2C=O)c(C2CCCCC2)c2sc(C(=O)OC(C)(C)C)cc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20090124596A1,NCc1ccccc1.O=C(O)c1cccc(-n2c(=O)n([C@@H]3CC[C@H](NC(=O)c4cn5cc(F)ccc5n4)CC3)c(=O)c3cc(F)cnc32)c1>>O=C(NCc1ccccc1)c1cccc(-n2c(=O)n([C@@H]3CC[C@H](NC(=O)c4cn5cc(F)ccc5n4)CC3)c(=O)c3cc(F)cnc32)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130059834A1,CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3n[nH]c4ccc(OC(F)F)cc34)nc12.CN(C)C(=O)CCCl>>CN(C)C(=O)CCn1nc(-c2cnc3c(n2)c(C(=O)NC(C)(C)C)cn3COCC[Si](C)(C)C)c2cc(OC(F)F)ccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050272036A1,Cc1ccccc1.O=C(Cl)Cc1ccccc1>>Cc1ccc(C(=O)Cc2ccccc2)cc1,,Cc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080071121A1,NCCCP(c1ccccc1)c1ccccc1.O=Cc1ccccc1>>C(=NCCCP(c1ccccc1)c1ccccc1)c1ccccc1,,CCO,,,,val
US20050070562A1,CS(=O)(=O)c1ccc(Nc2ncnc(OC3CCNCC3)c2[N+](=O)[O-])cc1.O=C(Cl)c1cccnc1Cl>>CS(=O)(=O)c1ccc(Nc2ncnc(OC3CCN(C(=O)c4cccnc4Cl)CC3)c2[N+](=O)[O-])cc1,,CN(C)C=O,,CCN(CC)CC,,val
US20070244159A1,BrBr.CC(C)(C)Nc1ccc([N+](=O)[O-])cc1>>CC(C)(C)Nc1ccc([N+](=O)[O-])cc1Br,,CC(=O)O,,,,val
US05859051,C=CCc1c(O)cccc1OCC(=O)CC>>CCCc1c(O)cccc1OCC(=O)CC,[Pd],CCOC(C)=O,,,,val
US20100267634A1,CC(C)(C)OC(=O)[C@H](N)c1ccccc1.CCOC(=O)CCCBr>>CCOC(=O)CCCN[C@@H](C(=O)OC(C)(C)C)c1ccccc1,,CC#N,CCOC(C)=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20140323464A1,Nc1ccc(N2CCOCC2)cc1.O=[N+]([O-])c1cccc(Nc2ccnc(Cl)n2)c1>>O=[N+]([O-])c1cccc(Nc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1,,CC(C)O,,O=C(O)C(F)(F)F,,val
US20060148858A1,CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.COC(=O)CCc1ccc(O)cc1>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1ccc(CCC(=O)O)cc1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20100249075A1,COc1ccc(C2Cc3c(C(N)=O)cc(OC)cc3C3CCCCC23)cc1>>COc1ccc(C2Cc3c(C#N)cc(OC)cc3C3CCCCC23)cc1,,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20100178247A1,Cn1ccnc1CN(CCc1ccc(S(N)(=O)=O)cc1)CC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>NS(=O)(=O)c1ccc(CCN(CC(=O)O)Cc2nccn2CC(=O)O)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US04447658,Cc1ccc(O)cc1C.[Br-].[Br-].[Ca+2]>>Cc1ccc(O)cc1C.[Br-].[Br-].[Ca+2],,Cc1ccccc1,,CCO,,val
US20030236250A1,C=C(C)CC1(CO)CCN(C(=O)OC(C)(C)C)CC1>>CC1(C)CC2(CCNCC2)CO1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160235716A1,CC(C)(C)OC(=O)CBr.O=C1NC(=O)C2(CCCc3ccccc32)N1>>CC(C)(C)OC(=O)CN1C(=O)NC2(CCCc3ccccc32)C1=O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100210623A1,FC(F)(F)C1CO1.[N-]=[N+]=[N-]>>[N-]=[N+]=NCC(O)C(F)(F)F,,CCO,,[Cl-].[NH4+],,val
US20100099840A1,CCCCCCCCCCCCN.O=C1OC(=O)c2cscc21>>CCCCCCCCCCCCNC(=O)c1cscc1C(=O)O,,Cc1ccccc1,,,,val
US05560749,C=CC(=O)NC.C[Si](C)(C)Cl>>C=CC(=O)N(C)[Si](C)(C)C,,CC#N,,CCN(CC)CC,,val
US20110275608A1,COC(=O)c1sc(-c2ccccn2)nc1C.O=C1CCC(=O)N1Br>>COC(=O)c1sc(-c2ccccn2)nc1CBr,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20140200344A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(C(=O)C3CCCCC3)ncnc21>>O=C(c1ncnc2[nH]ccc12)C1CCCCC1,,CO,ClC(Cl)Cl,Cl,,val
US20020193367A1,CC(C)(C)OC(=O)Nc1cc(Cl)c(C(F)(F)F)cc1[N+](=O)[O-].CNC(C)C>>CC(C)N(C)c1cc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])cc1C(F)(F)F,,CS(C)=O,,CCN(CC)CC,,val
US20070027118A1,CCOC(=O)Cc1cccc(NS(=O)(=O)N2CCc3ccccc3CC2)n1>>O=S(=O)(Nc1cccc(CCO)n1)N1CCc2ccccc2CC1,,C1CCOC1,ClCCl,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030216409A1,CN1C(=O)CN(C(=O)OC(C)(C)C)C1C(C)(C)C.C[C@H]1CNCCN1>>C[C@H]1CN(C(=O)OC(C)(C)C)CCN1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20120264731A1,COC(=O)c1cc(-c2cccn2C(=O)OC(C)(C)C)c2oc(N3CCO[C@H](C)C3)cc(=O)c2c1>>COC(=O)c1cc(C2CCCN2C(=O)OC(C)(C)C)c2oc(N3CCO[C@H](C)C3)cc(=O)c2c1,[Rh],CO,,,,val
US20060241145A1,Nc1ccc(OC(F)(F)F)c(Br)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1ccc(OC(F)(F)F)c(Br)c1)C(F)(F)F,,ClCCl,,CCN(CC)CC,O,val
US20050101644A1,O=C(O)c1cccnc1.OC(CN1CCNCC1)c1cc(Br)ccc1OCc1ccc(Cl)cc1>>O=C(c1cccnc1)N1CCN(CC(O)c2cc(Br)ccc2OCc2ccc(Cl)cc2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05710157,CCOC(=O)C(=Cc1cc(OC)ccc1OC)C(C)=O>>CCOC(=O)C(Cc1cc(OC)ccc1OC)C(C)=O,[Pd],CCOC(C)=O,,[H][H],,val
US20070244132A1,Clc1ncnc2cc[nH]c12.O=C(OCCI)c1ccccc1>>O=C(OCCn1ccc2ncnc(Cl)c21)c1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],O=C([O-])O.[Na+],val
US20140243322A1,COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)O)c1nnc(C)n1-2.NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO>>COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)c1nnc(C)n1-2,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US20090069337A1,Brc1cccc(N2CCC(OC3CCCCO3)C2)c1.NC(=O)CCC(=O)NCl.O=S=O>>O=S(=O)(Cl)c1cccc(N2CCC(OC3CCCCO3)C2)c1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US06511974B1,CN(C)C=O.Cn1cc(-c2ccc(C(=O)O)c(Cl)c2)cn1.O=C(Cl)C(=O)Cl>>Cn1cc(-c2ccc(C(=O)O)c(Cl)c2)cn1.O=C(Cl)Cl,,C1CCOC1,,,,val
US20080058369A1,CC(C)(C)OC(=O)c1ccc(NC(=O)CCCCCCCBr)cc1.CNCCO>>CN(CCO)CCCCCCCC(=O)Nc1ccc(C(=O)OC(C)(C)C)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20150353559A1,CS(=O)(=O)c1cc(Cl)cc(C(=O)O)c1>>CS(=O)(=O)c1cc(Cl)cc(CO)c1,,C1CCOC1,,,,val
US20100144710A1,C1CNCCN1.N#Cc1ncccc1Br>>N#Cc1ncccc1N1CCNCC1,,O,,CS(C)=O,,val
US20090181942A1,CCOc1c(OC)cccc1C(O)c1cc(Cl)ccc1N.COc1ccc(C=O)c(OC)c1>>CCOc1c(OC)cccc1C(O)c1cc(Cl)ccc1NCc1ccc(OC)cc1OC,,CC(=O)O,CCOC(C)=O,[BH4-].[Na+],,val
US04046768,CCNCC=O.O=C=Nc1ncc(Cl)s1>>CCN(CC=O)C(=O)Nc1ncc(Cl)s1,,CCO,O,c1ccccc1,,val
US20150126449A1,N#Cc1ncc(F)cc1F.NN>>Nc1n[nH]c2cc(F)cnc12,,CCO,,O,,val
US20040067202A1,FC(F)(F)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCc1ccccc1>>OCCOCCOCCOCCOCCOCCOCCOCCOCCOCC(F)(F)F,[Pd],CC(=O)O,CCO,,,val
US05047518,CCC12OC[C@@H](O1)[C@@H](OCc1ccccc1)C[C@H]2OC>>CCC12OC[C@@H](O1)[C@@H](O)C[C@H]2OC,[Pd],CCO,,CC(=O)O,[H][H],val
US20120238569A1,CCOC(C#CC(O)C(C)C)OCC>>CCOC(C#CC(=O)C(C)C)OCC,O=[Mn]=O,ClCCl,,,,val
US20130253194A1,Brc1cnn2ccc(N3CCNCC3)nc12.COCCOC(=O)Cl>>COCCOC(=O)N1CCN(c2ccn3ncc(Br)c3n2)CC1,,CCOC(C)=O,,,,val
US05747421,CCOC(=O)c1ccc(NC=O)cc1S(N)(=O)=O.COc1cc(OC)nc(NC(=O)Oc2ccccc2)n1>>COC(=O)c1ccc(NC=O)cc1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC)n1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20050020652A1,CCOC(=O)C(C)(Oc1ccc(C(F)(F)F)cc1)C(OC(=O)C(F)(F)F)c1cccc(OCc2ccccc2)c1>>CCOC(=O)C(C)(Cc1cccc(O)c1)Oc1ccc(C(F)(F)F)cc1,[Pd],CCOC(C)=O,,,,val
US20090137609A1,CCC(CC)(c1ccc(CCC(O[Si](C)(C)C(C)(C)C)C(C)(C)C)c(C)c1)c1ccc(-c2ccc(CC(=O)OC)cc2)c(C)c1>>CCC(CC)(c1ccc(CCC(O)C(C)(C)C)c(C)c1)c1ccc(-c2ccc(CC(=O)OC)cc2)c(C)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110046127A1,NCCc1ccc(Cl)c(Cl)c1.O=[N+]([O-])c1cnc2ccc(Cl)nn12>>CN(Cc1ccc(Cl)c(Cl)c1)c1ccc2ncc([N+](=O)[O-])n2n1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20150126522A1,CCC(C)Oc1cc(Br)cc(C(=O)OC)c1C>>CCC(C)Oc1cc(Br)cc(C(=O)O)c1C,,CO,,Cl,[Na+].[OH-],val
US20040259910A1,COc1cccc(C(=O)c2ncc(C=O)c3cc(OCc4ccccc4)c(OC)cc23)c1.O>>COc1cccc(C(=O)c2ncc(C(=O)O)c3cc(OCc4ccccc4)c(OC)cc23)c1,,CC(C)(C)O,O,CC=C(C)C,[Na+].[O-]Cl,val
US20040092582A1,COc1cc(CC(C)(C)NC(=O)c2ccc(=O)n(-c3ccc4cc(C)ccc4n3)c2)cc2c1OC(C)(C)C2>>COc1cc2c(c3c1OC(C)(C)C3)C(c1ccc(=O)n(-c3ccc4cc(C)ccc4n3)c1)=NC(C)(C)C2,,O,,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US20110237588A1,Brc1ccnc2ccccc12.CC(C)Cn1cc(B2OC(C)(C)C(C)(C)O2)c(-c2ccc(Cl)s2)n1>>CC(C)Cn1cc(-c2ccnc3ccccc23)c(-c2ccc(Cl)s2)n1,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20130158006A1,CN(CCO)C(=O)c1cc(Cl)c(N)cc1O>>CN1CCOc2cc(N)c(Cl)cc2C1=O,,ClCCl,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140155391A1,COC(=O)c1ccc(N)cc1OCC1CC1.CS(=O)(=O)Cl>>COC(=O)c1ccc(NS(C)(=O)=O)cc1OCC1CC1,,ClCCl,,Cl,c1ccncc1,val
US20090029979A1,BrCc1ccccc1.OC1(c2ccc(Br)cc2)CCNCC1>>OC1(c2ccc(Br)cc2)CCN(Cc2ccccc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04849424,Clc1ccnc(Cl)n1.c1c[nH]cn1>>Clc1ccnc(-n2ccnc2)n1,,C1CCOC1,,,,val
US05342846,Nc1c(F)c(F)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1.c1cn(C2CNC2)nn1>>Nc1c(F)c(N2CC(n3ccnn3)C2)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1,,c1ccncc1,,C1CCC2=NCCCN2CC1,Cl,val
US04535183,CCOC(=O)CCCCCBr.Oc1cccc2occc12>>CCOC(=O)CCCCCOc1cccc2occc12,,CCO,,[I-].[K+],O=C([O-])O.[Na+],val
US20140221346A1,CN.CS(=O)(=O)c1ncc(Br)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)n1>>CNc1ncc(Br)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)n1,,ClCCl,,CCN(CC)CC,Cl,val
US04200588,CSCc1cc(OC23CC4CC(CC(C4)C2)C3)ccc1N>>Cc1cc(OC23CC4CC(CC(C4)C2)C3)ccc1N,[Ni],CCO,,,,val
US20110098296A1,CS(=O)c1nccc(-c2ocnc2-c2cccc([N+](=O)[O-])c2)n1.Nc1cccc(F)c1>>O=[N+]([O-])c1cccc(-c2ncoc2-c2ccnc(Nc3cccc(F)c3)n2)c1,Cl,CC(=O)N(C)C,,,,val
US20110021520A1,CC(C)(C)OC(=O)NC1=NC(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)(C(F)(F)F)CCOC1.ClCCl>>Cl.N#Cc1ccc(C(=O)Nc2ccc(F)c(C3(C(F)(F)F)CCOCC(N)=N3)c2)nc1,,O=C(O)C(F)(F)F,,,,val
US20110269734A1,C1CCOC1.CCN=C=NCCCN(C)C.Cc1cc(OCCCC2CCN(C(=O)OC(C)(C)C)CC2)ccc1C(=O)O.NCCO>>On1nnc2ccccc21,,C1CCOC1,ClCCl,O,,val
US05284857,CC(C)=CC(=O)Cl.CNOC>>CON(C)C(=O)C=C(C)C,,ClCCl,,CCN(CC)CC,Cl,val
US20100099840A1,O=C(O)c1cscc1C(=O)O>>O=C1OC(=O)c2cscc21,,CC(=O)OC(C)=O,,,,val
US20090176778A1,CC(=O)NO.CN(C)C(On1nnc2cccnc21)=[N+](C)C.O=C(O)Cc1c(C(=O)N2CCC(c3ccc(F)cc3)C2)nc2c(C(F)(F)F)cc(-c3ccoc3)cn12>>Cc1noc(Cc2c(C(=O)N3CCC(c4ccc(F)cc4)C3)nc3c(C(F)(F)F)cc(-c4ccoc4)cn23)n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20110009441A1,CCOC(C)=C(C#N)C#N.COC(OC)N(C)C>>COC(C=CN(C)C)=C(C#N)C#N,,CO,,,,val
US06331521B1,CCOC(=O)c1ccc(C(=O)CBr)cc1.[N-]=[N+]=[N-]>>CCOC(=O)c1ccc(C(=O)CN=[N+]=[N-])cc1,,CN(C)C=O,,O,,val
US20110301176A1,O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccc(CN2CCNC3(CC3)C2)cc1>>O=C(N1CCN(Cc2ccccc2)CC12CC2)C(F)(F)F,,ClC(Cl)Cl,ClCCl,CCN(CC)CC,O=C([O-])O.[Na+],val
US20130237535A1,CC(C)(C)OC(=O)N1CCC2(CCC(=O)N(C3CC3)C2)CC1.O=S(=O)(Cl)c1ccc(Br)cc1>>O=C1CCC2(CCN(S(=O)(=O)c3ccc(Br)cc3)CC2)CN1C1CC1,CN(C)c1ccncc1,,,Cl,,val
US20160272584A1,CC(=O)Oc1ccc(C(=O)Cl)cc1CC=C(C)C.CN1CCC(Oc2ccc(-c3cccc(N)c3)cc2)CC1>>CC(=O)Oc1ccc(C(=O)Nc2ccc(-c3ccc(OC4CCN(C)CC4)cc3)cc2)cc1CC=C(C)C,,ClCCl,,c1ccncc1,,val
US20020052369A1,O=C1Cc2ccccc2N1.O=Cc1cc2cc(OCCN3CCCC3)ccc2[nH]1>>O=C1Nc2ccccc2C1=Cc1cc2cc(OCCN3CCCC3)ccc2[nH]1,,CCO,,C1CCNCC1,,val
US20110130380A1,CC1(C)COC(CI)CO1.[N-]=[N+]=[N-]>>CC1(C)COCC(CN=[N+]=[N-])O1,,CCOC(C)=O,O,CN(C)C=O,,val
US05286875,CC(=O)OC1CCC(=O)CC1.O=C(OO)c1cccc(Cl)c1>>CC(=O)OC1CCOC(=O)CC1,,ClC(Cl)Cl,,,,val
US20080167294A1,COC(=O)c1ccc2c(c1)CCC1C2=NN(c2ccc(C#N)c(OCc3ccccc3)c2)C1C1CCCC1>>COC(=O)c1ccc2c(c1)CCC1C2=NN(c2ccc(C#N)c(O)c2)C1C1CCCC1,[Pd],CCOC(C)=O,,[H][H],,val
US20090137595A1,CC(C)(C#N)c1ccc(N)cc1.O=C(O)c1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1>>CC(C)(C#N)c1ccc(NC(=O)c2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)cc1,CN(C)c1ccncc1,c1ccncc1,,CCN=C=NCCCN(C)C,Cl,val
US20110015157A1,C=CCC1(c2ccc(F)cc2)CCN([C@@H](C)c2ccccc2)C(=O)O1.O=[Os](=O)(=O)=O>>C[C@@H](c1ccccc1)N1CCC(CCO)(c2ccc(F)cc2)OC1=O,O=[Os](=O)(=O)=O,CCOC(C)=O,,C1CCOC1,O,val
US20130045964A1,CC(C)(C)OC(=O)CN.O=C(O)C(O)c1ccc(-c2noc(-c3cnn(-c4ccccc4)c3C(F)(F)F)n2)cc1>>CC(C)(C)OC(=O)CNC(=O)C(O)c1ccc(-c2noc(-c3cnn(-c4ccccc4)c3C(F)(F)F)n2)cc1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040048868A1,CCOc1cc2nc(-c3nn(C4CCCCO4)cc3[N+](=O)[O-])[nH]c2cc1CC>>CCOc1cc2nc(-c3nn(C4CCCCO4)cc3N)[nH]c2cc1CC,[Pd],CCO,,,,val
US20160068559A1,CNC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21.O=CCCN1C(=O)c2ccccc2C1=O>>CN(CCCN1C(=O)c2ccccc2C1=O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21,,ClCCCl,,O=C([O-])O.[Na+],,val
US20110183973A1,CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.Nc1cc(-c2cccc3[nH]ccc23)cc2nn(C3CCCCO3)cc12.O=C(O)Cc1ccccn1>>CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.F[P-](F)(F)(F)(F)F.O=C(Cc1ccccn1)Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12.O=C(O)Cc1ccccn1,,CN(C)C=O,,,,val
US20010051633A1,CC(O)CCN1CCC(Cc2ccc([N+](=O)[O-])cc2)CC1.Cl>>CC(O)CCN1CCC(Cc2ccc(N)cc2)CC1.Cl,[Pd],CO,,,,val
US06429314B1,CC(=O)C12CC3CC(CC(C3)C1)C2>>CC(O)C12CC3CC(CC(C3)C1)C2,,CO,O,Cl,[Na+].[OH-],val
US20020114973A1,O=C1CCC(=O)N1Br.c1ccc(-c2cccs2)cc1>>Brc1ccc(-c2ccccc2)s1,,CO,,,,val
US20050090533A1,C1CSCN1.Cc1cc(F)ccc1-c1cc(Cl)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>Cc1cc(F)ccc1-c1cc(N2CCSC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,[Na+],[OH-],,,val
US06211234B1,COc1ccc(C)c(C=O)c1>>Cc1ccc(O)cc1C=O,,O,,Cl,c1ccncc1,val
US20060229254A1,C=[N+]=[N-].CC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)O>>COC(=O)[C@H](CCC(C)=O)NC(=O)OCc1ccccc1,,C1CCOC1,,,,val
US20100022518A1,COCC(CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)N1CCN(c2cccc(C(F)(F)F)c2)C(C)C1=O>>COCC(CCO)N1CCN(c2cccc(C(F)(F)F)c2)C(C)C1=O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05373008,Nc1cc(C(F)(F)F)ccc1N1CCOCC1.S=C(Cl)Cl>>FC(F)(F)c1ccc(N2CCOCC2)c(N=C=S)c1,,C1COCCO1,O,,,val
US20150246912A1,CCOC(=O)CC(=NC(=O)C(C)(C)C)OCC.NN>>CCOC(=O)Cc1nc(C(C)(C)C)n[nH]1,,CO,,O,,val
US20060122168A1,CC(C)(C)OC(=O)N[C@@H](COc1c(Cl)cccc1[N+](=O)[O-])C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N[C@@H](COc1c(N)cccc1Cl)C(=O)O,[Ni],,,,,val
US20060004043A1,N#Cc1ccc(F)c(C(=O)c2ccc3cc(O)ccc3c2)c1.NN>>N#Cc1ccc2[nH]nc(-c3ccc4cc(O)ccc4c3)c2c1,,Cc1ccccc1,,O,,val
US20120322791A1,NC1(c2ccc(Br)cc2F)CC1.O=C(Cl)OCc1ccccc1>>O=C(NC1(c2ccc(Br)cc2F)CC1)OCc1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04988692,CCC(C)(C)ON=O.CN1C(=O)CC(=O)N(c2ccccc2)c2cc(Cl)ccc21>>Cn1c(=O)c(=NO)c(=O)n(-c2ccccc2)c2cc(Cl)ccc21,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20150252029A1,O=C(O)CC(=O)O.O=Cc1ccc(OCc2ccccn2)cc1F>>O=C(O)/C=C/c1ccc(OCc2ccccn2)cc1F,,O,c1ccncc1,C1CCNCC1,Cl,val
US20130210858A1,CCOC(=O)c1ccc2nn(CC)cc2c1>>CCn1cc2cc(CO)ccc2n1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20010039279A1,COC(=O)[C@H](CCCCNC(=O)/C=C/C=C/c1cc(OC)c(OC)c(OC)c1)NC(=O)/C=C/C=C/c1cc(OC)c(OC)c(OC)c1>>COc1cc(/C=C/C=C/C(=O)NCCCC[C@H](NC(=O)/C=C/C=C/c2cc(OC)c(OC)c(OC)c2)C(=O)O)cc(OC)c1OC,,C1CCOC1,CO,Cl,[K+].[OH-],val
US20080262028A1,CCOC(=O)C#N.CCOC(=O)Cc1cn(S(=O)(=O)c2ccc(C)cc2)cn1>>CCOC(=O)C(C(=O)OCC)c1cn(S(=O)(=O)c2ccc(C)cc2)cn1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100130506A1,COC(C)(C)OC.OC[C@H](O)COc1ccc(I)cc1>>CC1(C)OC[C@@H](COc2ccc(I)cc2)O1,,CN(C)C=O,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US04978753,CCOC(=O)c1cc(=O)nc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2>>O=c1ccn2c(n1)CN=C(c1ccccc1Cl)c1cc(Cl)ccc1-2,,c1ccncc1,,[I-].[Li+],,val
US20060079528A1,COC(=O)/C=C/c1ccc2ccccc2n1>>O=C(O)/C=C/c1ccc2ccccc2n1,,CO,,O,[Na+].[OH-],val
US20100075948A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.Nc1ccc(N)cc1>>CC(C)(C)CC1NC(C(=O)Nc2ccc(N)cc2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05576321,C1=CC2(CCNCC2)c2ccccc21.O=C(O)C(=O)O.c1cc(OC[C@@H]2CO2)c2cc[nH]c2c1>>O=C(O)C(=O)O.O[C@H](COc1cccc2[nH]ccc12)CN1CCC2(C=Cc3ccccc32)CC1,,CCOC(C)=O,,CO,,val
US20090209585A1,CCOC(=O)C1=CCCCC1S(=O)(=O)Nc1ccc(F)cc1Cl.Cc1cc(CBr)cc(C)c1OC(=O)CN(C)C(=O)OC(C)(C)C>>CCOC(=O)C1=CCCCC1S(=O)(=O)N(Cc1cc(C)c(OC(=O)CN(C)C(=O)OC(C)(C)C)c(C)c1)c1ccc(F)cc1Cl,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20100152452A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.CO.N[C@@H](CCC(=O)O)C(=O)O>>COC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)OC,,CCOC(C)=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20130203755A1,CS(=O)(=O)OCC(F)(F)F.Cc1ccc(S(=O)(=O)n2cc(-c3ccc4[nH]ccc4c3)c3cc(-c4ccc(CN5CCNCC5)cc4)cnc32)cc1>>FC(F)(F)CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US05296495,COC(=O)C(C)(C)Cc1ccc2oc(-c3nc(C(C)(C)C)cs3)cc2c1>>CC(C)(Cc1ccc2oc(-c3nc(C(C)(C)C)cs3)cc2c1)C(=O)O,,CO,,[Na+].[OH-],,val
US20130317221A1,Cc1cc(C#Cc2ccc(C(C)(C)C)cc2)ccc1N.Cc1nc2ccccc2c(=O)o1>>Cc1cc(C#Cc2ccc(C(C)(C)C)cc2)ccc1-n1c(C)nc2ccccc2c1=O,,CC(=O)O,,,,val
US20010014691A1,CCCCOc1cncc(Cl)c1.CN>>CNC(C)CCOc1cncc(Cl)c1,,CO,,Cl,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(O)C(F)(F)F)CC2)c2ccnn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(O)C(F)(F)F)CC2)c2ccnn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US05716624,C#Cc1ccc2c(c1)C(C)(C)CCS2.O=Cc1ccc(C(=O)O)cc1>>CC1(C)CCSc2ccc(C#CC(O)c3ccc(C(=O)O)cc3)cc21,,C1CCOC1,,O,[Li]CCCC,val
US20070232627A1,Nc1ccc(Oc2ccc(C(=O)Nc3ccc(Br)cc3)cc2[N+](=O)[O-])cc1.O=C(Cl)OCC(Cl)(Cl)Cl>>O=C(Nc1ccc(Oc2ccc(C(=O)Nc3ccc(Br)cc3)cc2[N+](=O)[O-])cc1)OCC(Cl)(Cl)Cl,,ClCCl,,c1ccncc1,,val
US20090099155A1,Cn1ccnc1-c1ccc(CN)cc1.O=C(N1CCc2ccc(Cl)c(OS(=O)(=O)C(F)(F)F)c2CC1)C(F)(F)F>>Cn1ccnc1-c1ccc(CNc2c(Cl)ccc3c2CCN(C(=O)C(F)(F)F)CC3)cc1,,Cc1ccccc1,,,,val
US20100184740A1,Cc1cc([N+](=O)[O-])ccc1-n1cccc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c1=O>>Cc1cc(N)ccc1-n1cccc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c1=O,[Pd],C1CCOC1,,[H][H],,val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.O=C(Nc1ccc(Br)cc1)c1cc(Br)cc(Br)c1O>>COc1cc2nccc(Oc3c(Br)cc(Br)cc3C(=O)Nc3ccc(Br)cc3)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,,,val
US20160046583A1,CNCC1CC1.O=C(O)c1ccc2cncc(-c3ccc(Cl)cc3)c2c1>>CN(CC1CC1)C(=O)c1ccc2cncc(-c3ccc(Cl)cc3)c2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US05223498,O=C(OC(=O)c1ccccc1)c1ccccc1.OCCN1CCNC1=Nc1ccccc1N1CCOCC1>>O=C(OCCN1CCNC1=Nc1ccccc1N1CCOCC1)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20080021217A1,COC(=N)CNC(=O)OCc1ccccc1.NNC(=O)c1c[nH]c2ncccc12>>O=C(NCc1nc(-c2c[nH]c3ncccc23)n[nH]1)OCc1ccccc1,,CO,,,,val
US05360800,Cc1c(CN2CCc3c(c4ccccc4n3C)C2=O)ncn1C(=O)OCc1ccccc1>>Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O,,CO,,CCO,Cl,val
US20070249659A1,Brc1ccccn1.COC(=O)c1ccc(O)cc1>>COC(=O)c1ccc(Oc2ccccn2)cc1,,[Na+],[OH-],O=C([O-])[O-].[K+].[K+],,val
US20100267748A1,COC(=O)CCc1ccc(Cl)c(Cl)c1.COC=O>>COC(=O)C(C=O)Cc1ccc(Cl)c(Cl)c1,,CCOCC,CCOCC,CC(C)(C)[O-].[K+],,val
US20070167433A1,COCCCN1CCOc2ccc(C(O[C@H]3CNC[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]3c3ccc(CCl)cc3)S(=O)(=O)c3ccc(C)cc3)cc21.OCC1CC1>>COCCCN1CCOc2ccc(C(O[C@H]3CNC[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]3c3ccc(COCC4CC4)cc3)S(=O)(=O)c3ccc(C)cc3)cc21,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20030176449A1,COc1cccc(-c2cnc3nc(C)ccn23)c1>>Cc1ccn2c(-c3cccc(O)c3)cnc2n1,,Br,CC(=O)O,[Na+].[OH-],,val
US05538988,NC1CCc2cc(F)c(F)cc2C1.S=C(n1ccnc1)n1ccnc1>>Fc1cc2c(cc1F)CC(N=C=S)CC2,,CCOC(C)=O,,,,val
US04894458,CC(C)(C)OC(=O)NC1CCNC1.CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)c(C)c21>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCC(NC(=O)OC(C)(C)C)C3)c(C)c21,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20110065702A1,Nc1ccc2[nH]ncc2c1.O=C1Nc2ccccc2C1=O>>O=C1Nc2ccccc2C1=Nc1ccc2[nH]ncc2c1,CC(=O)O,,,,,val
US04963575,CC(=O)CCC(C)=O.N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1SC(F)(F)F>>Cc1ccc(C)n1-c1c(SC(F)(F)F)c(C#N)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl,,Cc1ccccc1,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,,val
US20030203933A1,C=[N+]=[N-].CO.COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O>>COc1ccc(/C=C/C(=O)/C=C(O)/C=C/c2ccc(OC)c(OC)c2)cc1OC,,CO,,CCOCC,,val
US05066654,O=C(Nc1cccnc1NCc1ccccn1)c1ccc(Cl)cc1>>Clc1ccc(-c2nc3cccnc3n2Cc2ccccn2)cc1,,OCCO,,,,val
US20060128633A1,CC(C)(C)OC(=O)NCC(=O)NCCC(=O)O.COc1cc2c(c(OC)c1OC)-c1ccc(O)cc1C(NC(C)=O)CC2>>COc1cc2c(c(OC)c1OC)-c1ccc(OC(=O)CCNC(=O)CNC(=O)OC(C)(C)C)cc1[C@@H](NC(C)=O)CC2,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20120214803A1,Nc1ccc(F)c2cccnc12.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(Nc1ccc(F)c2cccnc12)c1ccccc1,CN(C)c1ccncc1,ClCCl,,,,val
US20110224129A1,CCCCOc1ccc(C(=O)CC(=O)c2ccc(C(=O)OC)cc2)cc1.NN>>CCCCOc1ccc(-c2cc(-c3ccc(C(=O)OC)cc3)[nH]n2)cc1,,CCO,,CC(=O)O,O,val
US20090036492A1,COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.Cc1cc(C=O)c2ccccc2c1>>COc1cc(O)c2c(c1C(=O)NCc1c(C)ccc3ccccc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,,CC#N,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20100029678A1,COC(=O)C1C[C@H]2O[C@H]2C1.[Li]CC>>CC[C@@H]1C[C@H](C(=O)OC)C[C@H]1O,[Cu]I,CCOCC,,,,val
US05312904,CNCC(S)(COC)COC.ClCc1ccccc1>>CNCC(COC)(COC)SCc1ccccc1,,CCOCC,,Cl,[Na+].[OH-],val
US20100093670A1,CCc1cc(C(=O)Cc2ccc3ccccc3c2)c(O)cc1O.COC([O-])OC>>CCc1cc2c(=O)c(-c3ccc4ccccc4c3)coc2cc1O,C1CCNCC1,CCOC(C)=O,,c1ccncc1,,val
US20120302610A1,Nc1ccc(-c2ccc(Cl)cc2)cc1.O=Cc1ccc(C(F)(F)F)cc1Br>>FC(F)(F)c1ccc(CNc2ccc(-c3ccc(Cl)cc3)cc2)c(Br)c1,,CCOC(C)=O,ClCCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100323994A1,COc1ccc(CN(c2ccccn2)c2cc(Cl)nn3c(C(=O)Nc4ccncc4F)cnc23)cc1.N[C@H]1CC[C@H](N)CC1>>COc1ccc(CN(c2ccccn2)c2cc(N[C@@H]3CC[C@@H](N)CC3)nn3c(C(=O)Nc4ccncc4F)cnc23)cc1,,CN1CCCC1=O,CO,,,val
US20100303804A1,CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCC[Se]c1ccccc1>>C=COC(=O)[C@H](Cc1ccccc1)NC(C)=O,,C1CCOC1,ClC(Cl)Cl,OO,,val
US20090270361A1,Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Oc1ccc(C(=O)NN)cc1.O=C(O)C1CC1>>Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Oc1ccc(-c2nnc(C3CC3)o2)cc1,,O=P(Cl)(Cl)Cl,,,,val
US20110152084A1,COc1nonc1N.CS(=O)(=O)c1ccc(C(=O)O)c(Cl)c1COCC(F)(F)F>>COc1nonc1NC(=O)c1ccc(S(C)(=O)=O)c(COCC(F)(F)F)c1Cl,CN(C)c1ccncc1,ClCCl,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US20040097507A1,Cc1onc(-c2ncc(C(F)(F)F)cc2Cl)c1C(=O)NC1CCCC(CNC(=O)OCc2ccccc2)C1>>Cc1onc2c1c(=O)n(C1CCCC(CNC(=O)OCc3ccccc3)C1)c1cc(C(F)(F)F)cnc21,,CN(C)C=O,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20120059030A1,CO.COc1cc(C(=O)O)ccc1F>>COC(=O)c1ccc(F)c(OC)c1,,CO,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20110288090A1,COc1nccc2nc(-c3ccc(C4OCCO4)cc3)c(-c3ccccc3)c(C#N)c12>>COc1nccc2nc(-c3ccc(C=O)cc3)c(-c3ccccc3)c(C#N)c12,,O,,CC(=O)O,Cl,val
US04906643,CN(CCCCO)C(=O)OC(C)(C)C>>CN(CCCC=O)C(=O)OC(C)(C)C,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20080269240A1,COC(=O)CN(C)C(=O)[C@H](Cc1ccc(C(=O)OC)cc1)NC(=O)OC(C)(C)C>>COC(=O)c1ccc(CC2NC(=O)CN(C)C2=O)cc1,,O=C(O)C(F)(F)F,,CCN(CC)CC,,val
US20160159808A1,CCOC(=O)CC(=O)OC(C)(C)C.O=[N+]([O-])c1cccnc1Cl>>CCOC(=O)C(C(=O)OC(C)(C)C)c1ncccc1[N+](=O)[O-],,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US06140317,O=[N+]([O-])c1ccc(-c2cc3c(N4CCc5ccccc54)ncnc3[nH]2)cc1>>Nc1ccc(-c2cc3c(N4CCc5ccccc54)ncnc3[nH]2)cc1,[Ni],C1CCOC1,CO,,,val
US20050054851A1,CN(C)CCCl.Oc1ccc(-c2ccncc2)cc1>>CN(C)CCOc1ccc(-c2ccncc2)cc1,,ClC(Cl)Cl,,Cl,,val
US20040058907A1,C#CCN.O=C(NC[C@@H]1CN(Cc2ccc(Cl)c(Cl)c2)CCO1)Oc1ccc([N+](=O)[O-])cc1>>C#CCNC(=O)NC[C@@H]1CN(Cc2ccc(Cl)c(Cl)c2)CCO1,,CCN(CC)CC,,ClCCl,,val
US20090253687A1,O=C1COc2ccc(C3=C(c4ccccc4)C(=O)OC3)cc2N1>>O=C1COc2ccc([C@@H]3COC(=O)[C@@H]3c3ccccc3)cc2N1,[Pd],CCO,CCOC(C)=O,,,val
US20110275611A1,CNc1nc(Cl)cc(N2C[C@@H](C(=O)O)CC[C@H]2C)n1.NC1CCCCC1>>CNc1nc(Cl)cc(N2C[C@@H](C(=O)NC3CCCCC3)CC[C@H]2C)n1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130079341A1,COC(=O)c1cccc(Br)c1.OB(O)c1ccsc1>>COC(=O)c1cccc(-c2ccsc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20140045862A1,OC1(c2cn[nH]c2)CCC(F)(F)CC1>>FC1(F)CC=C(c2cn[nH]c2)CC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20110039958A1,Brc1cccc(Br)c1OCc1ccccc1.CN(C)C=O.OB(O)c1cccnc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>c1ccc(COc2c(-c3cccnc3)cccc2-c2cccnc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060025383A1,O=[N+]([O-])c1ccc(Cn2cc(I)c3c(Cl)ncnc32)cc1.[NH4+]>>Nc1ncnc2c1c(I)cn2Cc1ccc([N+](=O)[O-])cc1,,C1COCCO1,,O,,val
US20150094297A1,COc1cc(O)c2cc(-c3cn4nc(OC)sc4n3)oc2c1.Cc1sc(C2CCOCC2)nc1CBr>>COc1cc(OCc2nc(C3CCOCC3)sc2C)c2cc(-c3cn4nc(OC)sc4n3)oc2c1,,CN(C)C=O,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20070208007A1,CCCI.N#Cc1ccc(N)c(NC(=O)CCCCCNC(=O)OCc2ccccc2)c1>>CCCN(C(=O)CCCCCNC(=O)OCc1ccccc1)c1cc(C#N)ccc1N,,CN(C)C=O,,O,[H-].[Na+],val
US05675004,CCCCCCBr.Oc1cc(O)c(-c2nc(-c3ccccc3)nc(-c3ccccc3)n2)cc1Cl>>CCCCCCOc1cc(O)c(-c2nc(-c3ccccc3)nc(-c3ccccc3)n2)cc1Cl,,CCOCCO,,[I-].[K+],,val
US20110021537A1,CCOC(=O)N1CCNCC1.C[C@H](NC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1)C(=O)O>>CCOC(=O)N1CCN(C(=O)[C@H](C)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)n(-c3ccccc3)n2)CC1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110015175A1,CN.COc1cc(Nc2nc3c(s2)CC(=O)CC3c2ccc(F)cc2)ccc1-n1cnc(Cl)c1>>CNC1Cc2sc(Nc3ccc(-n4cnc(Cl)c4)c(OC)c3)nc2C(c2ccc(F)cc2)C1,,CO,,[BH3-]C#N.[Na+],,val
US08138168B1,COC(=O)c1cccc([N+](=O)[O-])c1N.COCCCBr>>COCCCNc1c(C(=O)OC)cccc1[N+](=O)[O-],,CN(C)C=O,O,[H-].[Na+],,val
US20060183749A1,O=c1cc(CO)occ1OCCCCCBr.Oc1ccnc2c(C(F)(F)F)cccc12>>O=c1cc(CO)occ1OCCCCCOc1ccnc2c(C(F)(F)F)cccc12,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04906628,Nc1ccc(-c2c[nH]c(=O)cn2)cc1.O=c1ccocc1>>O=c1ccn(-c2ccc(-c3c[nH]c(=O)cn3)cc2)cc1,,O,,Cl,Cl,val
US20110263548A1,C[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1Oc1cc(=O)n(-c2ccc(C#N)c(F)c2)cc1Cl.Cl>>CC1CNCCC1Oc1cc(=O)n(-c2ccc(C#N)c(F)c2)cc1Cl.Cl,,CO,,,,val
US05366982,CCOC(=O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1>>CCOC(=O)CCCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1,,CCO,O,[Na],,val
US20120028938A1,COC(=O)Cc1c(C)n[nH]c1C.O=[N+]([O-])c1ccc(CBr)cc1>>COC(=O)Cc1c(C)nn(Cc2ccc([N+](=O)[O-])cc2)c1C,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US07179823B1,O=S(Cl)Cl.OCc1cnn(Cc2ccccc2)c1-c1ccccc1>>ClCc1cnn(Cc2ccccc2)c1-c1ccccc1,,Cc1ccccc1,,,,val
US20070167433A1,COCCCN1CCOc2ccc(COC3CN(C(=O)OCc4ccccc4)CC(O)C3c3ccc(OCCOCc4ccccc4Cl)cc3)cc21>>COCCCN1CCOc2ccc(COC3CNCC(O)C3c3ccc(OCCOCc4ccccc4Cl)cc3)cc21,,CCOC(C)=O,O,CO,[K+].[OH-],val
US20010051631A1,CCOC(=O)c1cccc2ncc(C(=O)C(Cl)(Cl)Cl)n12.Nc1ccc(CCNS(=O)(=O)C(F)(F)F)cc1>>O=c1c2cccc3ncc(c(=O)n1-c1ccc(CCNS(=O)(=O)C(F)(F)F)cc1)n32,,CC#N,,CCN(C(C)C)C(C)C,,val
US20140187786A1,CCOC(=O)C(CC(C)C)c1ccc(O)c(Br)c1.ClCc1ccccc1>>CCOC(=O)C(CC(C)C)c1ccc(OCc2ccccc2)c(Br)c1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150291531A1,COc1cc2ccc(Br)cc2[nH]c1=O.OB(O)c1ccc(F)cc1>>COc1cc2ccc(-c3ccc(F)cc3)cc2[nH]c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20140275027A1,COc1cc(C#N)ccc1-c1ccnc2[nH]c(C3CCCN(C(=O)OC(C)(C)C)C3)cc12>>COc1cc(C#N)ccc1-c1ccnc2[nH]c(C3CCCNC3)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120184542A1,CC(C)(C)OC(=O)NC[C@H](Cc1cccc(F)c1)NC(=O)c1ccc(Cl)c(N)c1.COC(=O)CC(=O)Cl>>COC(=O)CC(=O)Nc1cc(C(=O)N[C@H](CNC(=O)OC(C)(C)C)Cc2cccc(F)c2)ccc1Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150011773A1,CC(C)(C)OC(=O)N[C@@H](C[C@H](Cc1ccc(CCCO)cc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)OS(=O)(=O)c2ccc(C)cc2)cc1>>Cc1ccc(S(=O)(=O)OCCCc2ccc(C[C@@H](C[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc2)cc1,,c1ccncc1,,Cl,,val
US20030055085A1,N#Cc1ccccn1.NNC(=O)c1cccc(Cl)c1>>Clc1cccc(-c2nc(-c3ccccn3)n[nH]2)c1,,CO,,[Na],,val
US05910506,Cc1ncccc1Cn1c(CO)nc(C(C)C)c1Sc1cc(Cl)cc(Cl)c1.O=C=NC(=O)C(Cl)(Cl)Cl>>Cc1ncccc1Cn1c(COC(N)=O)nc(C(C)C)c1Sc1cc(Cl)cc(Cl)c1,,C1CCOC1,CO,CCN(CC)CC,O,val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.Cc1ccc(C(=O)CO)cc1C>>COc1cc2nccc(Oc3cc(C)c(C)cc3C(C)=O)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,O,,val
US20030166639A1,Cc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccc(C4CC4)nc3)c2)cc1C(F)(F)F>>Cc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3ccc(C4CC4)nc3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160194358A1,C=CC(=O)OC.CCCCCCCCCCN>>CCCCCCCCCCNCCC(=O)OC,,C1CCOC1,,,,val
US20160115128A1,C1=COCCC1.COc1ncc(Br)c(N2CCC(CO)CC2)n1>>COc1ncc(Br)c(N2CCC(COC3CCCCO3)CC2)n1,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US06326506B1,C=Cc1ccccc1.C[SiH](C)Cl>>C[Si](C)(Cl)CCc1ccccc1,[Pt],Cc1ccccc1,,,,val
US20140194411A1,CCOC(=O)N1CCc2ccc3c(c2CC1)C(CC)C(F)(F)C3>>CCC1c2c(ccc3c2CCNCC3)CC1(F)F,,ClC(Cl)Cl,,C[Si](C)(C)I,,val
US20080085890A1,COC(OC)OC.O=C1Cc2ccccc2C(=O)N1>>COC=C1C(=O)NC(=O)c2ccccc21,,CN(C)C=O,,CC(=O)OC(C)=O,,val
US04315933,Nc1ccc(-c2ncc(C(=O)O)c(O)n2)cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(O)c1cnc(-c2ccc(NC(=O)C(F)(F)F)cc2)nc1O,,ClCCl,,CCN(CC)CC,C[Si](C)(C)Cl,val
US05707994,CCOC(=O)[C@@H](N)CNC(=O)OC(C)(C)C.O=S(=O)(Cl)c1ccccc1>>CCOC(=O)[C@H](CNC(=O)OC(C)(C)C)NS(=O)(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,O,val
US06008230,C=C(C)C(=O)O.NNc1ccnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc12>>C=C(C)C(=O)NNc1ccnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc12,,CCOC(C)=O,CN(C)C=O,On1nnc2ccccc21,,val
US20060154977A1,Cc1cc2c(cc1[N+](=O)[O-])=NC(=O)N=2>>Cc1cc2c(cc1N)=NC(=O)N=2,[Pd],CCO,,,,val
US20150111869A1,Cn1nccc1Nc1nccc(=O)[nH]1.O=P(Cl)(Cl)Cl>>Cn1nccc1Nc1nccc(Cl)n1,,CC#N,,,,val
US20100056527A1,CCOC(=O)C(=O)CC(C)=O.NNCc1cc(Cl)cc(Br)c1O>>CCOC(=O)c1cc(C)n(Cc2cc(Cl)cc(Br)c2O)n1,,CC(=O)O,CCO,Cl,,val
US20150126449A1,Cc1ccccc1-c1cccc2nn3c(C4CCN(C(=O)OC(C)(C)C)CC4)cc(=O)[nH]c3c12.Cl>>Cc1ccccc1-c1cccc2nn3c(C4CCNCC4)cc(=O)[nH]c3c12.Cl,,C1COCCO1,,,,val
US20110021570A1,COC(=O)C(CC(C)C)n1ccc(Oc2cccc(F)c2F)cc1=O>>CC(C)CC(C(=O)O)n1ccc(Oc2cccc(F)c2F)cc1=O,,CO,,[Na+].[OH-],,val
US20160184305A1,CC(=O)C(C)=O.CCOc1cc(N)c(N)cc1Br>>CCOc1cc2nc(C)c(C)nc2cc1Br,,CO,,[Cl-].[NH4+],,val
US20100240638A1,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](OC(=O)N2Cc3cccc(F)c3C2)CN1)C(=O)NS(=O)(=O)c1ccccc1NCCOCCOCCC(=O)O.CN(C)C=O>>C=C[C@@H]1C[C@]1(N=C=O)C1NC(=O)[C@@H]2C[C@@H](OC(=O)N3Cc4cccc(F)c4C3)CN2C(=O)CCOCCOCCNc2ccccc2S(=O)(=O)NC1=O,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130131018A1,BrCCCc1ccccc1.COc1cc(C=O)cc(OC)c1O>>COc1cc(C=O)cc(OC)c1OCCCc1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05912247,C1=CC(Oc2nc(N3CCNCC3)nc3ccccc23)CC1.O=C(Cl)OCc1ccccc1>>O=C(OCc1ccccc1)N1CCN(c2nc(OC3C=CCC3)c3ccccc3n2)CC1,,ClC(Cl)Cl,ClCCl,CCN(CC)CC,,val
US20090170913A1,Nc1cccc2sc(Cl)nc12.O=C(O)c1ccc(-c2ccc(F)cc2)cc1>>O=C(Nc1ccc2nc(Cl)sc2c1)c1ccc(-c2ccc(F)cc2)cc1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20040048868A1,ClCCN1CCOCC1.O=[N+]([O-])c1ccc(O)cc1[N+](=O)[O-]>>O=[N+]([O-])c1ccc(OCCN2CCOCC2)cc1[N+](=O)[O-],,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120252777A1,CS(=O)(=O)c1cccc(N)c1.Clc1nc(Cl)c2ncsc2n1>>CS(=O)(=O)c1cccc(Nc2nc(Cl)nc3scnc23)c1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US20130158009A1,CCc1cnc(Cl)nc1.CS(=O)(=O)c1cc(F)c(N[C@H]2CCCN(C3CCNCC3)C2=O)cc1F>>CCc1cnc(N2CCC(N3CCC[C@H](Nc4cc(F)c(S(C)(=O)=O)cc4F)C3=O)CC2)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20150376120A1,C=CCOC(=O)c1ccc([N+](=O)[O-])cc1OCC=C>>C=CCOC(=O)c1ccc(N)cc1OCC=C,,CCO,,Cl[Sn]Cl,,val
US04604243,C=C(C)C#N.Cl.Nc1ccccc1>>CC(Cl)(C#N)Cc1ccccc1,,CC#N,,,,val
US20090306175A1,COC(=O)[C@@H]1C[C@@H](c2ccccc2)CN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)C[C@H]1CO,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20140100250A1,Br[Mg]C1CC1.COC(=O)[C@@H]1CC[C@@H](C(=O)c2nccs2)CC1>>COC(=O)[C@@H]1CC[C@@H](C(O)(c2nccs2)C2CC2)CC1,,C1CCOC1,,,,val
US20030225064A1,COB(OC)OC.Cc1ccc(Br)s1>>Cc1ccc(B(O)O)s1,,C1CCOC1,,Cl,[Li]CCCC,val
US04820719,COC(=O)C(OC)C(O)c1ccccc1CCCCCCCCc1ccccc1.COC(=O)CCS>>COC(=O)CCSC(c1ccccc1CCCCCCCCc1ccccc1)C(OC)C(=O)OC,,O=C(O)C(F)(F)F,,,,val
US05776931,N#CCc1ccccc1.Nc1cc2ccccc2cc1N>>c1ccc(Cc2nc3cc4ccccc4cc3[nH]2)cc1,,CO,,Cl,O,val
US20040067964A1,COC(=O)OC.CSc1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1>>COC(=O)c1cc2cc(SC)cnc2n1S(=O)(=O)c1ccccc1,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US06969714B2,COCCOCCO.Cc1ncc(-c2ccnc(Nc3ccc(S(=O)(=O)NC(=O)OC(C)(C)C)cc3)n2)n1C>>COCCOCCN(C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Nc2nccc(-c3cnc(C)n3C)n2)cc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020038858A1,Br.CCC[C@@H]1CC[C@@H]([C@@H]2CC[C@@H](CCCO)CC2)CC1>>CCC[C@@H]1CC[C@@H]([C@@H]2CC[C@@H](CCCBr)CC2)CC1,,O,,Cc1ccccc1C,,val
US20080306124A1,Nc1ccc(-c2cc(-c3ccc(-c4ccccc4)c(C(F)(F)F)c3)on2)cc1.O=C1CCC(=O)O1>>O=C(O)CCC(=O)Nc1ccc(-c2cc(-c3ccc(-c4ccccc4)c(C(F)(F)F)c3)on2)cc1,,ClCCl,,CN1CCOCC1,,val
US04634708,CI.CN1Cc2ccccc2[C@H]2c3cccc4[nH]cc(c34)C[C@@H]21>>CN1Cc2ccccc2[C@H]2c3cccc4c3c(cn4C)C[C@@H]21,,CN(C)C=O,,[H-].[Na+],,val
US20060035938A1,C=Cc1cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)n(-c2cccc(C(F)(F)F)c2)c1C>>CCc1cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)n(-c2cccc(C(F)(F)F)c2)c1C,[Pd],CCO,CCOC(C)=O,,,val
US20100105679A1,ClCCN1CCOCC1.O=c1cc(OCc2ccccc2)ccn1-c1ccc2[nH]ncc2c1>>O=c1cc(OCc2ccccc2)ccn1-c1ccc2c(cnn2CCN2CCOCC2)c1,,CS(C)=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120245144A1,CC(=O)c1ccc2c(c1)-c1nc(-c3ncnn3C(C)C)cn1CCO2>>CC(O)c1ccc2c(c1)-c1nc(-c3ncnn3C(C)C)cn1CCO2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06794395B1,CCC(CC)(C1(OC)C=CC=CC1)P(=O)([O-])[O-].O=C1Nc2cc3c(cc2C1=O)OCO3>>COC(=C1C(=O)Nc2cc3c(cc21)OCO3)c1ccccc1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20160046648A1,C=O.CC(C)(C)OC(=O)N1CCCc2[nH]nc(C(=O)N3CCC(c4ccccc4C(F)(F)F)CC3)c2C1>>CN1CCCc2[nH]nc(C(=O)N3CCC(c4ccccc4C(F)(F)F)CC3)c2C1,,CCOCC,CO,Cl,O=C([O-])O.[Na+],val
US20100179216A1,O=C1CCC(=O)N1Br.OCCCc1ccc(Cl)cc1>>Clc1ccc(CCCBr)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120208839A1,CNc1nc(OCCF)c(C(=O)N[C@@H]2CC[C@@H](C(F)(F)F)CC2)cc1[N+](=O)[O-]>>CNc1nc(OCCF)c(C(=O)N[C@@H]2CC[C@@H](C(F)(F)F)CC2)cc1N,[Ni],C1CCOC1,,CO,,val
US20080090845A1,CCN.CCOC(=O)[C@@H](N)C#N.CCOC(OCC)OCC>>CCOC(=O)c1ncn(CC)c1N,,CC#N,CCOC(C)=O,,,val
US20090275602A1,CCOC(C)=O.COCOc1ccc(CC(C)(C)C)nc1C#N.C[Mg]Cl>>COCOc1ccc(CC(C)(C)C)nc1C(C)=O,,C1CCOC1,,CCCCCC,,val
US20050288503A1,Cn1cnc2c(Cl)nc(I)nc21.Nc1c(F)cccc1F>>Cn1cnc2c(Nc3c(F)cccc3F)nc(I)nc21,,CS(C)=O,,[H-].[Na+],[Cl-].[NH4+],val
US20150051197A1,FC(F)(F)c1ccc(Cl)nc1.O=S1(=O)CCN2C(=N1)C1(c3ccc(O)cc3)CCC2CC1>>O=S1(=O)CCN2C(=N1)C1(c3ccc(Oc4ccc(C(F)(F)F)cn4)cc3)CCC2CC1,,O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20120083475A1,CCOC(=O)C=O.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>CCOC(=O)c1cnco1,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US20160251380A1,CC1OB2OC(CNC(=O)OC(C)(C)C)C(Br)=C3C=COCC1=C23.Cl>>CC1OB2OC(CN)C(Br)=C3C=COCC1=C23.Cl,,CCOCC,,,,val
US20140088101A1,CCOC(=O)c1c(CN(CC(=O)OC)S(=O)(=O)c2ccc(C)cc2)ccc(=O)n1Cc1ccccc1>>COC(=O)c1ncc2ccc(=O)n(Cc3ccccc3)c2c1O,,CO,,Cl,C[O-].[Na+],val
US20090062279A1,CC1CCC(C(C)C)C(S(=O)[O-])C1.COc1cccc2ncc(Br)cc12>>COc1cccc2ncc(S(=O)c3ccc(C)cc3)cc12,,C1CCOC1,,CC(C)[Mg]Cl,[Cl-].[NH4+],val
US20140107044A1,CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](N=C=S)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.NCCCF>>CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](NC(=S)NCCCF)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20160031899A1,C=C1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@@]1(C)CC[C@H](NC(C)=O)C[C@@H]1[C@@H](O)[C@@H]3O>>C=C1CC[C@H]2[C@H](C=O)[C@@H]([C@@]3(C)CC[C@H](NC(C)=O)C[C@@H]3C=O)CC[C@]12C,,C1CCOC1,O,,,val
US20040019209A1,COC(=O)N(C)CC(=O)c1ccc(Cl)cc1.NN>>COC(=O)N(C)CC(=NN)c1ccc(Cl)cc1,,CCCO,,CC(=O)O,O,val
US20050203081A1,CCOC(=O)COc1c(C(=O)OC)sc2cc(-c3sccc3C=O)ccc12>>CCOC(=O)COc1c(C(=O)OC)sc2cc(-c3sccc3CO)ccc12,,C1CCOC1,,O,[BH4-].[Na+],val
US20120134959A1,CC1(C)OB(c2ccc([N+](=O)[O-])cc2)OC1(C)C.Clc1cc(N2CC3CCC(C2)O3)nc(I)n1>>O=[N+]([O-])c1ccc(-c2nc(Cl)cc(N3CC4CCC(C3)O4)n2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20150198876A1,O=C(O)C1(C(F)(F)F)CC2C=CC1C2>>O=C(O)C1(C(F)(F)F)CC2CCC1C2,[Pd],Cc1ccccc1,,,,val
US20110281884A1,CON(C)C(=O)c1cc(Cl)c2cncn2c1-c1cccc(F)c1.C[Mg]Br>>CC(=O)c1cc(Cl)c2cncn2c1-c1cccc(F)c1,,C1CCOC1,O,Cl,O=C([O-])O.[Na+],val
US20060004013A1,CCOC(=O)/C(=C/c1ccc(-n2cnc(C)c2)c(OC)c1)CCCCl.NC1CCOc2ccccc21>>CCOC(=O)/C(=C/c1ccc(-n2cnc(C)c2)c(OC)c1)CCCNC1CCOc2ccccc21,,CC#N,O,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20160235727A1,CC[Mg]Br.CON(C)C(=O)c1cc(C)n[nH]1>>CCC(=O)c1cc(C)n[nH]1,,C1CCOC1,,,,val
US06586519B1,CCCCCCCCCCCCBr.O=C(c1ccc(Cl)cc1)c1ccc(O)cc1O>>CCCCCCCCCCCCOc1ccc(C(=O)c2ccc(Cl)cc2)c(O)c1,,CCC(C)O,,O,O=C([O-])O.[Na+],val
US08829187B1,C=CCO[C@@H](C(=O)OC(C)C)[C@H](Cc1cc(C)cc(-n2c(C)ccc2C)n1)C(=O)OC(C)C>>C=CCO[C@@H](CO)[C@@H](CO)Cc1cc(C)cc(-n2c(C)ccc2C)n1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030232863A1,CC(C)(C)[Si](C)(C)Cl.CC(C)C[C@H](N)CO>>CC(C)C[C@H](N)CO[Si](C)(C)C(C)(C)C,CN(C)c1ccncc1,O,,CCN(CC)CC,ClCCl,val
US04344948,O=C(CBr)c1cccc(Cl)c1.O=C1Nc2ccccc2CN1C1CCNCC1>>O=C(CN1CCC(N2Cc3ccccc3NC2=O)CC1)c1cccc(Cl)c1,,CO,,CCN(CC)CC,Cl,val
US20080312226A1,CC(=O)Nc1ccc(NC(=O)OCC(Cl)(Cl)Cl)cn1.CCc1sc(N2CCNCC2)nc1-c1ccccc1>>CCc1sc(N2CCN(C(=O)Nc3ccc(NC(C)=O)nc3)CC2)nc1-c1ccccc1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US20140371199A1,CCOC(=O)c1ccc(-c2cn3c(Br)cnc3cn2)cc1>>O=C(O)c1ccc(-c2cn3c(Br)cnc3cn2)cc1,,C1CCOC1,CO,O,[Li+].[OH-],val
US20160251339A1,O=C(N1CCN(c2cc(S(=O)(=O)n3cc(C(F)F)c4ccc(Br)cc43)ccc2OCC(F)(F)F)CC1)C(Cl)(Cl)Cl>>O=S(=O)(c1ccc(OCC(F)(F)F)c(N2CCNCC2)c1)n1cc(C(F)F)c2ccc(Br)cc21,,C1CCOC1,,[K+].[OH-],,val
US20140155407A1,CC(O)c1ccc(-c2ccccc2)nc1.O=C(n1ccnc1)n1ccnc1>>CC(OC(=O)n1ccnc1)c1ccc(-c2ccccc2)nc1,,CC#N,,,,val
US04423064,C#CC(C)C(C(=O)OCC)C(C)C>>C#CC(C)C(C(=O)O)C(C)C,,O,,CCO,[Na+].[OH-],val
US20140163017A1,C/C(C=O)=C\c1cc(Cl)ccc1O.Cc1ccc(S(=O)(=O)NN)cc1>>Cc1cn[nH]c1-c1cc(Cl)ccc1O,,CC#N,,[Na+].[OH-],,val
US20140248378A1,O=c1[nH]c(SCc2ccccc2)ncc1OC1CCCCO1>>O=c1[nH]c(SCc2ccccc2)ncc1O,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090176841A1,CCOC(=O)C(=O)Nc1cccc2c1ccn2Cc1ccc(O)c(C(C)C)c1>>CC(C)c1cc(Cn2ccc3c(NC(=O)C(=O)O)cccc32)ccc1O,,CCO,,[Na+].[OH-],,val
US20130085142A1,COC(=O)CNC[C@@H]1C[C@@H](Oc2cnc(C3CC3)cn2)CN1>>O=C1CNC[C@@H]2C[C@@H](Oc3cnc(C4CC4)cn3)CN12,,CO,,CCN(CC)CC,Cl,val
US20110251372A1,CC(C)(C)OC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.Cl.Cl>>Cl.Cl.N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1,,C1CCOC1,CC(=O)O,,,val
US20080194576A1,O=C1CCC2(CC1)OCCO2.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>O=S(=O)(OC1=CCC2(CC1)OCCO2)C(F)(F)F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US04410354,C=C(CC)CCC1(O)CCOCC1.CC(=O)OO>>CCC1(CO)CCC2(CCOCC2)O1,,ClCCl,,,,val
US20090142297A1,NCc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1ccc(Cl)cc1>>O=C1CCC(N2C(=O)c3ccc(CNC(=O)c4ccc(Cl)cc4)cc3C2=O)C(=O)N1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20140274689A1,O=C1C(=O)C(Cl)=C(Cl)C(Cl)=C1Cl.[N-]=[N+]=CC(=O)c1cccs1>>O=C(c1cccs1)C1Oc2c(Cl)c(Cl)c(Cl)c(Cl)c2O1,,c1ccccc1,,,,val
US20020198376A1,CC(=O)N(CCS)CCc1ccccc1.Cl>>Cl.SCCNCCc1ccccc1,,CC(=O)O,,,,val
US20060063779A1,O=C1CCC(=O)N1Cl.c1ccc(CNc2nc(-c3ccccn3)cs2)cc1>>Clc1sc(NCc2ccccc2)nc1-c1ccccn1,,CN(C)C=O,,,,val
US20070243568A1,[N-]=[N+]=NCCCn1cnc2c(OCc3ccc(CNC(=O)C(F)(F)F)cc3)nc(N)nc21>>[N-]=[N+]=NCCCn1cnc2c(OCc3ccc(CN)cc3)nc(N)nc21,,CO,,CN,,val
US20090281092A1,CC(C)(C)OC(=O)N1CC(N)C1.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C>>COc1cc(C(=O)NC2CNC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130165412A1,CCOC(=O)C([O-])=C1C[C@H]2C[C@H]2C1=O.NNc1cnccn1>>CCOC(=O)c1nn(-c2cnccn2)c2c1C[C@H]1C[C@@H]21,,CCO,O,Cl,,val
US20120004203A1,BrBr.CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)c2nnnn2C1c1ccc(C#N)cc1>>CCOC(=O)C1=C(CBr)N(c2cccc(C(F)(F)F)c2)c2nnnn2C1c1ccc(C#N)cc1,,ClC(Cl)Cl,,,,val
US20110288069A1,CN1CCN2c3ccccc3NC(=O)CC2C1>>CN1CCN2c3ccccc3NCCC2C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070232627A1,Nc1ccc(Sc2ccc(C(=O)Nc3ccc(Br)cc3)cc2[N+](=O)[O-])cc1.O=C(Cl)OCC(Cl)(Cl)Cl>>O=C(Nc1ccc(Sc2ccc(C(=O)Nc3ccc(Br)cc3)cc2[N+](=O)[O-])cc1)OCC(Cl)(Cl)Cl,,ClCCl,,c1ccncc1,,val
US20040157891A1,COc1ccc(-c2nc(S(C)(=O)=O)oc2-c2ccc(OC)cc2)cc1.Nc1ccccn1>>COc1ccc(-c2nc(Nc3ccccn3)oc2-c2ccc(OC)cc2)cc1,,C1COCCO1,,[H-].[Na+],,val
US20060281767A1,ClCl.O=c1ccnc[nH]1>>O=C1[NH2+]C=NC=C1Cl.[Cl-],,CC(=O)O,,,,val
US20040034036A1,COc1ccccc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1.O=S(=O)(O)Cl>>COc1ccc(S(=O)(=O)Cl)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1,,ClCCl,,,,val
US20110243865A1,C1COCCN1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>c1ccc(C(c2ccccc2)(c2ccccc2)N2CCOCC2)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20090203692A1,CC(C)(C)OC(=O)NCC(=O)NCc1ccc(Cl)c(NC2=NC(=O)/C(=C/c3ccc4ncccc4c3)S2)c1>>NCC(=O)NCc1ccc(Cl)c(NC2=NC(=O)/C(=C/c3ccc4ncccc4c3)S2)c1,,O=C(O)C(F)(F)F,,,,val
US20010039344A1,CCOC(=O)C(=O)c1ccc(SC)c(Cl)c1>>CCOC(=O)C(O)c1ccc(SC)c(Cl)c1,,CO,,[BH4-].[Na+],,val
US20070212569A1,CCOS(=O)(=O)OCC.Oc1ccc2cc(Br)ccc2c1Br>>CCOc1ccc2cc(Br)ccc2c1Br,,CO,O,CCOC(C)=O,[Na+].[OH-],val
US20060035921A1,COC(OC)OC.Nc1cc(Br)cnc1Nc1ccc(OCc2ccccc2)cc1>>Brc1cnc2c(c1)ncn2-c1ccc(OCc2ccccc2)cc1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120245152A1,C[C@@H](CBr)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.O=C(OCc1ccccc1)c1ccc(-c2ccccc2O)cc1F>>C[C@@H](COc1ccccc1-c1ccc(C(=O)OCc2ccccc2)c(F)c1)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20100137299A1,NCCCN1C(=O)C2(COc3cc4c(cc32)CCO4)c2ccccc21.O=C(Cl)c1ccccc1OC(F)(F)F>>O=C(NCCCN1C(=O)C2(COc3cc4c(cc32)CCO4)c2ccccc21)c1ccccc1OC(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US06114532,CCOC(=O)CC1(C(=O)c2ccc3c(c2)nc(Cc2ccc(C(=N)N)cc2)n3C)CCCCC1>>Cn1c(Cc2ccc(C(=N)N)cc2)nc2cc(C(=O)C3(CC(=O)O)CCCCC3)ccc21,,CCO,O,Cl,[Na+].[OH-],val
US07034045B1,CC(C)S(=O)(=O)NCC(C)(O)c1ccc(O)cc1.N#Cc1ccccc1CBr>>CC(C)S(=O)(=O)NCC(C)(O)c1ccc(OCc2ccccc2C#N)cc1,,CN(C)C=O,O,[H-].[Na+],,val
US20160000760A1,O=[N+]([O-])c1ccc(-c2ccccc2)c(Cl)c1>>Nc1ccc(-c2ccccc2)c(Cl)c1,[Fe],O,,CO,[Cl-].[NH4+],val
US20140155415A1,C=Cc1ccccc1Br.O=S(=O)(N=Cc1cc2ccccc2o1)c1ccc2c(c1)OCCCO2>>C=Cc1ccccc1C(NS(=O)(=O)c1ccc2c(c1)OCCCO2)c1cc2ccccc2o1,,C1CCOC1,CCCCCC,[Li]CCCC,O=C([O-])O.[Na+],val
US20040147513A1,CC(C)c1ccc(CC(C)(C)NCC(O)c2cc(OCc3ccccc3)cc3c2OCC(=O)N3)cc1>>CC(C)c1ccc(CC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1,[Pd],CO,,,,val
US20080207728A1,CC(=O)NC(Cc1c[nH]c2c(F)cc(F)cc12)C(=O)O>>NC(Cc1c[nH]c2c(F)cc(F)cc12)C(=O)O,,Cl,,,,val
US20140088075A1,CCn1c(=O)c(-c2cc(N)c(F)cc2Cl)cc2cnc(Cl)cc21.N#Cc1cccc(N=C=O)c1>>CCn1c(=O)c(-c2cc(NC(=O)Nc3cccc(C#N)c3)c(F)cc2Cl)cc2cnc(Cl)cc21,,C1CCOC1,,c1ccncc1,,val
US20160200703A1,COc1ccc(I)cc1.OC12CC3CC(CC(C3)C1)C2>>COc1ccc(I)cc1C12CC3CC(CC(C3)C1)C2,,ClCCl,O,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20160060273A1,CCOC(=O)C1(C)CCN(C2=NOC3(C2)CN(Cc2cc(Cl)c(-c4ccc(F)cc4)c(OCC)c2)C3)CC1>>CCOc1cc(CN2CC3(CC(N4CCC(C)(C(=O)O)CC4)=NO3)C2)cc(Cl)c1-c1ccc(F)cc1,,CCO,,[Na+].[OH-],,val
US04622323,CC(=O)Nc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-]>>Nc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],,O=S(=O)(O)O,,,,val
US20150099277A1,CC(=O)OC[C@H]1OC(OC(C)=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.O=C(O)C(F)(F)F>>CC(=O)OC[C@H]1OC(OC(C)=O)[C@@H](N)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05646184,CC(C)=CCCC(C)=CCCC(C)=CCCl.COC(=O)c1ccc(O)cc1O>>COC(=O)c1ccc(OC/C=C(\C)CC/C=C(\C)CCC=C(C)C)cc1O,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20080177095A1,CCCCCC1CCc2c(c(F)c(F)c3oc(C)cc23)O1>>CCCCCC1CCc2c3c(c(F)c(F)c2O1)OC(C)C3,[Pd],C1CCOC1,,,,val
US20150166480A1,CC(C)(F)CN1CCC(COc2ccc(Br)cc2F)CC1.CCOC(=O)c1ccc(B(O)O)cc1F>>COC(=O)c1ccc(-c2ccc(OCC3CCN(CC(C)(C)F)CC3)c(F)c2)cc1F,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04021542,NN.O=C[C@H](OCc1ccccc1)[C@H](OCc1ccccc1)[C@H](O)COCc1ccccc1>>NNC(=O)[C@H](OCc1ccccc1)[C@H](OCc1ccccc1)[C@H](O)COCc1ccccc1,,CO,,O,,val
US20120058988A1,COc1cccc(-c2ccc(F)c(C#N)c2)c1.Nc1ccncc1>>COc1cccc(-c2ccc(Nc3ccncc3)c(C#N)c2)c1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US06344484B1,COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1.O=C1c2ccccc2C(=O)N1OCCCO>>COC(=O)[C@H](Cc1ccc(OCCCON2C(=O)c3ccccc3C2=O)cc1)NC(=O)OCc1ccccc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060004017A1,COc1cc2c(Oc3ccccc3)ncnc2cc1OCCCN1CCOCC1>>COc1cc2c(=O)[nH]cnc2cc1OCCCN1CCOCC1,,Cl,,,,val
US20040192653A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1cc(F)ccc1N>>CC(C)(C)OC(=O)NCc1cc(F)ccc1N,,C1COCCO1,CCOCC,Cl,O=C([O-])O.[Na+],val
US04895951,CCN(CC)C(=O)CCl.COCCOC.NCc1ccccn1>>NC(=O)c1cccnc1C(N)=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070247063A1,CC(C)(C)c1ccc2cc3ccccc3c(-c3ccccc3)c2c1.O=C1CCC(=O)N1Br>>CC(C)(C)c1ccc2c(Br)c3ccccc3c(-c3ccccc3)c2c1,,O,,CN(C)C=O,,val
US04140778,Clc1nc(Cl)c(Cl)c(Cl)c1Cl.Nc1ccc([N+](=O)[O-])cc1C(F)(F)F>>O=[N+]([O-])c1ccc(Nc2c(Cl)c(Cl)nc(Cl)c2Cl)c(C(F)(F)F)c1,,CN(C)C=O,,,,val
US06344484B1,O=C1c2ccccc2C(=O)N1OCCCOCc1ccccc1>>O=C1c2ccccc2C(=O)N1OCCCO,[Pd],CCO,,[H][H],,val
US20130065914A1,Cc1csc2ncnc(O)c12.O=C1CCC(=O)N1Cl>>Cc1c(Cl)sc2nc[nH]c(=O)c12,,CC(=O)O,,,,val
US20060275913A1,Cc1ccc(C#N)cc1[N+](=O)[O-]>>Cc1ccc(C#N)cc1N,[Pd],CCO,,[H][H],,val
US20070213339A1,CCOC(=O)c1cn(-c2ccc(CN3CCCC3)cc2)c2c(OC(F)(F)Cl)c(F)c(F)cc2c1=O.c1ccc(N2CCNCC2)nc1>>CCOC(=O)c1cn(-c2ccc(CN3CCCC3)cc2)c2c(OC(F)(F)Cl)c(N3CCN(c4ccccn4)CC3)c(F)cc2c1=O,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20140018313A1,CC(C)(C)OC(=O)N1[C@H]2CC[C@H](C2)[C@H]1C(=O)Nc1ccc2cc(Br)ccc2c1N>>CC(C)(C)OC(=O)N1[C@H]2CC[C@H](C2)[C@H]1c1nc2ccc3cc(Br)ccc3c2[nH]1,,CCOC(C)=O,,CC(=O)O,[Na+].[OH-],val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Nc1ccc(Cc2ccccc2)cc1>>COc1ccc2nc(Nc3ccc(Cc4ccccc4)cc3)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US20130210809A1,COCC(=O)C(=CN(C)C)C(=O)OC.NN>>COCc1n[nH]cc1C(=O)OC,,CCCCO,,CC(=O)O,O,val
US20110112135A1,CCc1nc2c(C(F)(F)F)cccn2c1-c1ccc(Br)nc1.CS(=O)(=O)c1cccc(B(O)O)c1>>CCc1nc2c(C(F)(F)F)cccn2c1-c1ccc(-c2cccc(S(C)(=O)=O)c2)nc1,,COCCOCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20040048915A1,Brc1cccc2cc[nH]c12.CCI>>CCn1ccc2cccc(Br)c21,,CN(C)C=O,,[H-].[Na+],,val
US20160096839A1,C#CC1CC1.COc1cc(-c2cc(Cl)ccc2N)ncn1.C[Si](C)(C)N=[N+]=[N-]>>COc1cc(-c2cc(Cl)ccc2-n2cc(C3CC3)nn2)ncn1,,CC#N,ClCCl,CC(C)CCON=O,,val
US20030232869A1,Cc1cc(C#N)ccc1Nc1c(C(=O)NOCC2CC2)cc2[nH]c(COCC[Si](C)(C)C)nc2c1F>>Cc1cc(C#N)ccc1Nc1c(C(=O)NOCC2CC2)cc2[nH]cnc2c1F,,CCO,,Cl,[Na+].[OH-],val
US20050203078A1,C=CC=C.COC(=O)c1ccc(N=O)c(Cl)c1>>COC(=O)c1ccc(N2CC=CCO2)c(Cl)c1,,ClC(Cl)Cl,,,,val
US20100305066A1,CC1(C)CC(=O)c2sc(N3CCOCC3)c(-c3cccc(NC(=O)C(=O)O)c3)c2C1.NCCN1CCCC1>>CC1(C)CC(=O)c2sc(N3CCOCC3)c(-c3cccc(NC(=O)C(=O)NCCN4CCCC4)c3)c2C1,,ClCCl,,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,,val
US20120022078A1,O=Cc1ccc(F)nc1>>OCc1ccc(F)nc1,,O,,CO,[BH4-].[Na+],val
US20160009744A1,OCc1cc(Cc2cccc(Cl)c2)c(Cl)o1>>O=Cc1cc(Cc2cccc(Cl)c2)c(Cl)o1,O=[Mn]=O,ClCCl,,,,val
US20100105744A1,C=C[Mg]Br.CSCc1cc(F)ccc1[N+](=O)[O-]>>CSCc1cc(F)cc2cc[nH]c12,,C1CCOC1,,[Cl-].[NH4+],,val
US20140171435A1,Nc1cccc2cccc(N)c12.OB(O)c1ccc(F)c(Cl)c1>>Fc1ccc(B2Nc3cccc4cccc(c34)N2)cc1Cl,,Cc1ccccc1,,,,val
US20080214641A1,CCOC(=O)C(C)(F)F.COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)N)c1>>COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)NC(=O)C(C)(F)F)c1,,CC#N,,,,val
US06194446B1,O=Cc1cccc(OCCc2coc(-c3ccccc3)n2)c1>>OCc1cccc(OCCc2coc(-c3ccccc3)n2)c1,,CC(C)O,,O,[BH4-].[Na+],val
US20080058329A1,CN[C@@H]1C[C@@H](c2cn(S(=O)(=O)c3ccc(C)cc3)c3ccccc23)c2ccccc21>>CN[C@@H]1C[C@@H](c2c[nH]c3ccccc23)c2ccccc21,,CC(C)=O,CO,O,[Na+].[OH-],val
US20130096146A1,COc1cccc(N(C)c2nc(NC(=O)C(C)(C)C)nc3[nH]c4ccccc4c23)c1>>COc1cccc(N(C)c2nc(N)nc3[nH]c4ccccc4c23)c1,,CO,ClC(Cl)Cl,[Na+].[OH-],,val
US20070249688A1,COC(=O)c1ccc(C(CC(C)C)Sc2ccc(Br)cc2)cc1>>CC(C)CC(Sc1ccc(Br)cc1)c1ccc(C(=O)O)cc1,,CCO,,[Na+].[OH-],,val
US20060281772A1,C1CNCCN1.CC(C)(C)OC(=O)N1CCC(c2ncnc3cc(F)ccc23)CC1>>CC(C)(C)OC(=O)N1CCC(c2ncnc3cc(N4CCNCC4)ccc23)CC1,,CS(C)=O,O,,,val
US20150336925A1,CCOC(=O)c1[nH]c2c(Br)c(Cl)ccc2c1CCCOc1cc(C)c(Cl)c(C)c1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>CCOC(=O)c1[nH]c2c(-c3cnn(C)c3)c(Cl)ccc2c1CCCOc1cc(C)c(Cl)c(C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,COCCOC,O=C([O-])[O-].[Cs+].[Cs+],,val
US05753679,Nc1ccc(C(=O)O)cn1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(O)c1ccc(NC(=O)C(F)(F)F)nc1,,C1CCOC1,,,,val
US20150119392A1,CC(C)C#N.O=C(NCCBr)OCc1ccccc1>>CC(C)(C#N)CCNC(=O)OCc1ccccc1,,C1CCOC1,O,CC(C)NC(C)C,[Li]CCCC,val
US20070106080A1,O=C(Nc1ccccc1)C(F)(F)F.O=P(Cl)(Oc1ccccc1)Oc1ccccc1>>FC(F)(F)C(Cl)=Nc1ccccc1,,CCOC(C)=O,,CC#N,CCN(CC)CC,val
US20030065193A1,COC(=O)c1ccccc1S(=O)(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O>>O=C(O)c1ccccc1S(=O)(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O,,C1COCCO1,,Cl,[Na+].[OH-],val
US20100179211A1,CC(C)(C)OC(=O)N1CCC(O)(c2cccc(Cl)c2F)C1>>OC1(c2cccc(Cl)c2F)CCNC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04792547,Nc1ccccc1.O=C(Nc1nnn[nH]1)c1cncc(Cl)n1>>O=C(Nc1nnn[nH]1)c1cncc(Nc2ccccc2)n1,,CS(C)=O,,O,[Na+].[OH-],val
US20020052340A1,CCCCCC.CCNCC.CCO.C[C@H](O)C(=O)c1cccc(Cl)c1>>C[C@H]1NC(C)(C)CO[C@]1(O)c1cccc(Cl)c1,,CCO,,,,val
US20150344518A1,CN(C)CCCl.Oc1ccc(Br)cc1>>CN(C)CCOc1ccc(Br)cc1,,ClCCl,,CO,Cl,val
US20100240072A1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.Oc1cccc2[nH]nnc12>>CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.On1nnc2ccccc21,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20070281933A1,CC(C)S(=O)(=O)Cl.NC(=O)c1cc(-c2ccccc2)cc2c(C3CCNCC3)n[nH]c12>>CC(C)S(=O)(=O)N1CCC(c2n[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)CC1,CN(C)c1ccncc1,CN(C)C=O,,CCN(CC)CC,Cl,val
US20110046137A1,CCOc1cccc(Br)n1.O=C(Cc1cn[nH]c1)NCc1ccc(F)cc1Cl>>CCOc1cccc(-n2cc(CC(=O)NCc3ccc(F)cc3Cl)cn2)n1,I[Cu]I,CN1CCCC1=O,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US20060172994A1,CC(C)(C)OC(=O)N1CC2OC2C1.O=C(c1ccc(Cl)cc1)N1CCNCC1>>CC(C)(C)OC(=O)N1CC(O)C(N2CCN(C(=O)c3ccc(Cl)cc3)CC2)C1,,CC#N,,,,val
US20130150344A1,O=[N+]([O-])c1ccc(-n2cc(F)c(F)c2)cc1OCc1ccccc1>>Nc1ccc(-n2cc(F)c(F)c2)cc1OCc1ccccc1,[Zn],CC(=O)O,,C1CCOC1,,val
US20100234427A1,CCC(=O)N(CC1CCN(C(=O)OC(C)(C)C)CC1)c1ccc(Cl)cc1>>CCC(=O)N(CC1CCNCC1)c1ccc(Cl)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20010056100A1,COC(=O)[C@@H](Cc1ccccc1)N=C=O.OCc1ccc(OCCc2ccccc2)cc1>>COC(=O)[C@@H](Cc1ccccc1)NC(=O)OCc1ccc(OCCc2ccccc2)cc1,CN(C)c1ccncc1,,,,,val
US20120149699A1,COC(=O)c1nc2ccc(C(F)(F)F)cn2c1C>>Cc1c(C(=O)O)nc2ccc(C(F)(F)F)cn12,,CO,O,Cl,[Na+].[OH-],val
US20150005293A1,C1COCCN1.Cc1cnc(-n2cc(C(=O)NCC34CC5CC(CC(C5)C3)C4)c(C)n2)nc1C(=O)O>>Cc1cnc(-n2cc(C(=O)NCC34CC5CC(CC(C5)C3)C4)c(C)n2)nc1C(=O)N1CCOCC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20040009983A1,COc1ccc2c(c1)c(-c1cc3cccnc3n1S(=O)(=O)c1ccc(C)cc1)cn2C>>COc1ccc2c(c1)c(-c1cc3cccnc3[nH]1)cn2C,,CO,,[K+].[OH-],,val
US04734419,CCOC(=O)CBr.O=c1[nH]c2ccccc2c(=O)n1Cc1ccc(Cl)c(Cl)c1>>CCOC(=O)Cn1c(=O)n(Cc2ccc(Cl)c(Cl)c2)c(=O)c2ccccc21,,CN(C)C=O,,Cl,[H-].[Na+],val
US20160009701A1,BrCC1CC1.Cc1noc(C)c1-c1cc(C(N)=O)c2[nH]c3cc(N4CCCS4(=O)=O)ccc3c2c1>>Cc1noc(C)c1-c1cc(C(N)=O)c2c(c1)c1ccc(N3CCCS3(=O)=O)cc1n2CC1CC1,,CC(C)=O,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20010053779A1,N.O=[N+]([O-])c1c(F)cc(F)c(F)c1F>>Nc1c(F)c(F)cc(F)c1[N+](=O)[O-],,O,,C1COCCO1,,val
US20040248981A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(NC/C=C/c3cccc(C#N)c3)cc2)CC1.CCOC(=O)CBr>>CCOC(=O)CN(C/C=C/c1cccc(C#N)c1)c1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110070192A1,O=c1ccn([C@@H]2CO[C@@H]3COC(c4ccccc4)O[C@H]3[C@@H]2O)c(=O)[nH]1>>O=c1ccn([C@@H]2CO[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)[nH]1,,CCOC(C)=O,CO,Cl,,val
US20100022529A1,C1=COCCC1.CCOC(=O)c1cc2[nH]ncc2cc1O>>CCOC(=O)c1cc2c(cnn2C2CCCCO2)cc1O,,C1CCOC1,ClCCl,CS(=O)(=O)O,,val
US04496567,CN(C)Cc1cccc(CSCCN)c1.Cc1ccc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)cn1>>Cc1ccc(Cc2cnc(NCCSCc3cccc(CN(C)C)c3)[nH]c2=O)cn1,,CCO,,,,val
US20110301031A1,BrCc1ccccc1.CON1CCC2(CC1)NC(=O)C(c1c(C)cc(C)cc1C)=C2O>>CON1CCC2(CC1)NC(=O)C(c1c(C)cc(C)cc1C)=C2OCc1ccccc1,,CC(C)=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20060116357A1,COCCNCCO.O=C(Cc1cc(Nc2ncnc3cc(OCCCCl)ccc23)n[nH]1)Nc1cccc(F)c1>>COCCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1,,CN1CCCC1=O,,[I-].[K+],,val
US20070099990A1,Cc1c(NC(=O)CC(C)(C)C)cc2c(c1C)OC(C)(C)C2(O)Cc1ccccc1>>Cc1c(NC(=O)CC(C)(C)C)cc2c(c1C)OC(C)(C)C2Cc1ccccc1,,CCCCCC,CCOC(C)=O,,,val
US20130274255A1,C[Si](C)(C)CCOCn1nc(-c2ccc(N3CCOCC3)cc2)c2c1-c1ccsc1C2>>c1cc2c(s1)Cc1c(-c3ccc(N4CCOCC4)cc3)n[nH]c1-2,,CO,,Cl,,val
US20120178736A1,CC(Cl)c1nc2ccccc2[nH]1.CO>>COC(C)c1nc2ccccc2[nH]1,,CO,,C[O-].[Na+],,val
US20060063759A1,Nc1ccc(Br)cc1N.O=C(Cl)Oc1ccccc1>>O=c1[nH]c2ccc(Br)cc2[nH]1,,CO,O,[Na+].[OH-],,val
US20080171769A1,Cc1ccc(S(=O)(=O)Cl)cc1.OC[C@@H](O)c1cccc(Cl)c1>>Cc1ccc(S(=O)(=O)OC[C@@H](O)c2cccc(Cl)c2)cc1,,ClCCl,,CCN(CC)CC,,val
US04496571,C=C(Cl)C#N.N=C(N)CCCCCN1C(=O)c2ccccc2C1=O>>Nc1ccnc(CCCCCN2C(=O)c3ccccc3C2=O)n1,,CCO,,CCN(CC)CC,Cl,val
US20060217376A1,Fc1ccccc1-n1nc(OC2CCNCC2)c2ccccc21.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>Fc1ccccc1-n1nc(OC2CCNCC2)c2ccccc21.O=C(O)[C@H](O)[C@@H](O)C(=O)O,,CO,,N#N,,val
US20100041891A1,O=Cc1cc2nccc(Cl)c2s1>>OCc1cc2nccc(Cl)c2s1,,O,,CCO,[BH4-].[Na+],val
US06350749B1,Cc1ccnc2c1C(=O)CC(c1ccsc1Br)C2.Cl.N=C(N)NN>>Cc1ccnc2c1C(=NNC(=N)N)CC(c1ccsc1Br)C2.Cl,,CCO,,Cl,,val
US20110118246A1,Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12.O=C(O)c1ncccc1Cl>>O=C(Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12)c1ncccc1Cl,,CN(C)C=O,CO,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130225620A1,CC#N.CON(C)C(=O)[C@@H]1C[C@H]1c1ccccc1>>N#CCC(=O)[C@@H]1C[C@H]1c1ccccc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20150126449A1,Cc1nnc2nn3c(=O)cc(C4CCN(C(=O)OC(C)(C)C)CC4)[nH]c3c2c1C.Cl>>Cc1nnc2nn3c(C4CCNCC4)cc(=O)[nH]c3c2c1C.Cl,,C1COCCO1,CO,,,val
US04409214,C=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)C(=NOC)C(CBr)(OCC)OCC)[C@H]2SC1>>C=CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOC)C(=O)CBr)[C@H]2SC1,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20060264415A1,O.O=C(O)CSCC(=O)NCCCCCC(=O)Nc1cccc(-c2ccccc2)c1>>O=C(O)CS(=O)CC(=O)NCCCCCC(=O)Nc1cccc(-c2ccccc2)c1,,CO,,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US04383945,C=CC[C@@H]1CC(=O)N1C(C(=O)OC)=C(C)C.O>>COC(=O)C(=C(C)C)N1C(=O)C[C@H]1CC(C)=O,Cl[Pd]Cl,CCOC(C)=O,O,CN(C)C=O,,val
US20040259912A1,COC(=O)c1cc(N)ccc1OC(c1ccccc1F)c1ccccc1F.COc1ccc(N=C=O)cc1OC>>COC(=O)c1cc(NC(=O)Nc2ccc(OC)c(OC)c2)ccc1OC(c1ccccc1F)c1ccccc1F,,C1CCOC1,,,,val
US04937350,ClCl.Nc1nc(S)n[nH]1.O=S(=O)(O)O>>Nc1nc(S(=O)(=O)Cl)n[nH]1,,Cl,,,,val
US06265434B1,C[C@H](CI)C1CCN(C(=O)OC(C)(C)C)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[C@H](C[P+](c1ccccc1)(c1ccccc1)c1ccccc1)C1CCN(C(=O)OC(C)(C)C)CC1.[I-],,CC#N,,,,val
US20060211720A1,CCc1ccc(F)c(Br)c1.CN(C)C=O>>CCc1cc(Br)c(F)c(C=O)c1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20120178931A1,COC(=O)c1cc(Cl)cc(Cl)c1.O=[N+]([O-])O>>COC(=O)c1cc(Cl)cc(Cl)c1[N+](=O)[O-],,ClCCl,,O=S(=O)(O)O,,val
US20040106604A1,CCCCC([Sn])=C(CCCC)CCCC.Cc1cccc(-c2nn3c(c2-c2ccnc4cc(Br)ccc24)CCC3)n1>>C=Cc1ccc2c(-c3c(-c4cccc(C)n4)nn4c3CCC4)ccnc2c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,,,,val
US20130023541A1,CC(C)C(=O)N1CC[C@@H](NC(=O)OC(C)(C)C)C1.CCBr>>CCN(C(=O)OC(C)(C)C)[C@@H]1CCN(C(=O)C(C)C)C1,,CN(C)C=O,,O,[H-].[Na+],val
US05506267,CCCCCCCCCCCCCCCC(=O)OCC(CSCCC(=O)Nc1ccc(S(=O)(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1)OC(=O)CCCCCCCCCCCCCCC>>CCCCCCCCCCCCCCCC(=O)OCC(CSCCC(=O)Nc1ccc(S(=O)(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)OC(=O)CCCCCCCCCCCCCCC,,O=C(O)C(F)(F)F,,,,val
US20100069381A1,NNC(=O)c1ccc2c(c1)CCO2.O=C=NCc1cccc(F)c1>>O=C(NCc1cccc(F)c1)NNC(=O)c1ccc2c(c1)CCO2,,CCOC(C)=O,c1ccncc1,,,val
US20040092582A1,CC1(C)Cc2cc(O)c3c(c2C(c2ccccc2)=N1)CC(C)(C)O3.CCCCI>>CCCCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccccc1)=NC(C)(C)C2,,CN(C)C=O,,O,[H-].[Na+],val
US20050096324A1,C=CCO.Nc1cncc(Cl)n1>>C=CCOc1cncc(N)n1,,C1COCCO1,,[H-].[Na+],,val
US20060074056A1,CSc1cc2ncnc(Cl)c2s1.O=[N+]([O-])c1ccc(O)c(F)c1>>CSc1cc2ncnc(Oc3ccc([N+](=O)[O-])cc3F)c2s1,,c1ccc(Oc2ccccc2)cc1,,O=C([O-])[O-].[K+].[K+],,val
US20130157923A1,CC(=O)OCCC(C)CC1CC(C)CC(C)(C)C1>>CC(CCO)CC1CC(C)CC(C)(C)C1,,O,,[Na+].[OH-],,val
US05082932,COC(=O)c1ccc2c(N=O)c(O)ccc2c1.O=S([O-])O>>COC(=O)c1ccc2c(N)c(O)cc(S(=O)(=O)O)c2c1,,O,,[Na+].[OH-],,val
US06114325,CCCCCCCCCCCCCCCCCCNC(=O)OCc1ccccc1N(C=O)CCCN(C)C.Cl>>CCCCCCCCCCCCCCCCCCNC(=O)OCc1ccccc1N(C=O)CCCN(C)C.Cl,,CCOC(C)=O,,,,val
US20110306612A1,COC(=O)c1cccc(NC(=O)c2cnccn2)c1N>>Nc1c(NC(=O)c2cnccn2)cccc1C(=O)O,,C1CCOC1,,[Na+].[OH-],,val
US20050250768A1,CCOC(=O)C1CCCCN1C(=O)/C=C/c1ccc(Sc2ccccc2C(C)C)c([N+](=O)[O-])c1>>CC(C)c1ccccc1Sc1ccc(/C=C/C(=O)N2CCCCC2C(=O)O)cc1[N+](=O)[O-],,O,,,,val
US20040158066A1,COc1c(OCc2ccccc2)cnc(COC(C)=O)c1C>>COc1c(OCc2ccccc2)cnc(CO)c1C,,CO,,C[O-].[Na+],,val
US20130131039A1,Cn1cc(-c2cc3nccn3c(-c3cnn(C4(CC#N)CCNCC4)c3)n2)cn1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>Cn1cc(-c2cc3nccn3c(-c3cnn(C4(CC#N)CCN(CC(F)(F)F)CC4)c3)n2)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20100249418A1,CC(Br)C(=O)c1ccc(F)cc1.Nc1ccc(I)cn1>>Cc1c(-c2ccc(F)cc2)nc2ccc(I)cn12,,CC#N,,,,val
US05245046,COC(=O)C=O.NCc1ccccc1.c1ccc2[nH]ccc2c1>>COC(=O)C(NCc1ccccc1)c1c[nH]c2ccccc12,,CO,,CC(=O)O,,val
US20070105891A1,Cc1nc(N)cs1.Cc1nc2c(Cl)ncc(-c3cccnc3)c2s1>>Cc1nc(Nc2ncc(-c3cccnc3)c3sc(C)nc23)cs1,,C1COCCO1,,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20130109677A1,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccsc1>>CCOC(=O)C=Cc1ccsc1,,C1CCOC1,,,,val
US20110319385A1,CCOC(=O)[C@@H]1CCC[C@@H]1OCc1ccccc1>>O=C(O)[C@@H]1CCC[C@@H]1OCc1ccccc1,,C1CCOC1,,[Li+].[OH-],,val
US05104888,C=CC(=O)OCC.Cc1c(C)c2c(c(C)c1OCC(=O)OC(C)(C)C)C(=O)CC(C)(COc1ccc(N)cc1)O2.Cl>>CCOC(=O)C(Cl)Cc1ccc(OCC2(C)CC(=O)c3c(C)c(OCC(=O)OC(C)(C)C)c(C)c(C)c3O2)cc1,,CC(C)=O,O,O=N[O-].[Na+],,val
US03957766,NNc1ccc(Cl)nn1.O=Cc1ccc([N+](=O)[O-])s1>>O=[N+]([O-])C1=CCC(=NNc2ccc(Cl)nn2)S1,,CCO,,,,val
US20110052578A1,Cc1ccc(F)c(Br)c1.O=C=O>>Cc1cc(Br)c(F)c(C(=O)O)c1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20140073799A1,CN(C)C=O.ClC(Cl)Cl.O=[N+]([O-])c1ccc(F)cc1.OC1CCNCC1>>CCC1CC(O)CCN1c1ccc([N+](=O)[O-])cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06734193B1,CC(C)=CC(=O)Cl.CC(C)c1ccc(N)cc1>>CC(C)=CC(=O)Nc1ccc(C(C)C)cc1,,ClCCl,,c1ccncc1,,val
US20070043064A1,CCCN(c1cccc(C(=O)C=CN(C)C)c1)S(=O)(=O)C(C)C.Nc1[nH]ncc1[N+](=O)[O-]>>CCCN(c1cccc(-c2ccnc3c([N+](=O)[O-])cnn23)c1)S(=O)(=O)C(C)C,,CC(=O)O,,CCOC(C)=O,,val
US20140329799A1,COc1nc(SC)nc(Cl)c1I.N[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O>>COc1nc(SC)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1I,,CCO,,CCN(CC)CC,Cl,val
US20150183802A1,COc1cc2cc[nH]c(=O)c2cc1F>>O=c1[nH]ccc2cc(O)c(F)cc12,,ClCCl,,BrB(Br)Br,O,val
US20010006969A1,C=CCN.Cc1csc2c(NNC(C)(C)C)nc(Cl)nc12>>C=CCNc1nc(NNC(C)(C)C)c2scc(C)c2n1,,CCCCCC,CCOC(C)=O,O=C([O-])O.[Na+],,val
US08367677B2,COC(=O)c1ccc(N)cc1.COc1cc(CCC(=O)O)cc(OC)c1OC>>COC(=O)c1ccc(NC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,N#N,val
US20050096337A1,CCCCc1nc(-c2ccc(C(F)(F)F)cc2)ncc1CCl.CCOC(=O)C(C)(C)Oc1ccc(O)cc1>>CCCCc1nc(-c2ccc(C(F)(F)F)cc2)ncc1COc1ccc(OC(C)(C)C(=O)OCC)cc1,,CCOCC,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04363808,NCCCn1cnc2ccccc21.O=Cc1ccccc1>>c1ccc(CNCCCn2cnc3ccccc32)cc1,[Pd],CCO,,[H][H],,val
US04367234,O=C1NC(=S)OC1c1ccc2ccccc2c1.OO>>O=C1NC(=O)C(c2ccc3ccccc3c2)O1,,ClC(Cl)Cl,O,CCO,,val
US20110178132A1,N#Cc1cc(Cl)ccn1.Oc1ccccc1C(F)(F)F>>N#Cc1cc(Oc2ccccc2C(F)(F)F)ccn1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20060009451A1,c1cc2nc3c(c(-c4ccc(OC5CCCCO5)cc4)n2n1)COC3>>Oc1ccc(-c2c3c(nc4ccnn24)CCCC3)cc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060241142A1,CN1CCC(CN)(c2ccc(F)cc2)CC1.COc1cc(C(=O)Cl)c2ccccc2c1Cl>>COc1cc(C(=O)NCC2(c3ccc(F)cc3)CCN(C)CC2)c2ccccc2c1Cl,,CCOCC,,,,val
US04478750,C=O.c1ccc(-n2c3c(c4ccccc42)CCNCC3)cc1>>CN1CCc2c(n(-c3ccccc3)c3ccccc23)CC1,[Ni],CCO,,,,val
US20160031865A1,COc1ncccc1[C@H]1COC[C@H]1CO.O=Cc1c(O)cccc1O>>COc1ncccc1[C@@H]1COC[C@H]1COc1cccc(O)c1C=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110230497A1,CC(C)(C)OC(=O)N1CCC(CC(=O)Nc2ccc(-c3ccccc3)cc2)CC1>>O=C(CC1CCNCC1)Nc1ccc(-c2ccccc2)cc1,,C1COCCO1,,Cl,,val
US05208247,CC(=O)NCc1ccccn1.CCCCCCCCCCCCCCOc1ccc(CBr)cc1>>CCCCCCCCCCCCCCOc1ccc(CN(Cc2ccccn2)C(C)=O)cc1,,C1CCOC1,,[H-].[Na+],,val
US06413974B1,Clc1nc(Cl)c2ncn(C3CCCC3)c2n1.NCCc1ccc(O)cc1>>Oc1ccc(CCNc2nc(Cl)nc3c2ncn3C2CCCC2)cc1,,CCN(CC)CC,,Cl,,val
US20030236280A1,NC1CCc2cc(F)ccc2C1Cc1ccccc1.O=C(Nc1cccc2c(Cl)nccc12)Oc1ccccc1>>O=C(Nc1cccc2c(Cl)nccc12)NC1CCc2cc(F)ccc2C1Cc1ccccc1,,CS(C)=O,,Cl,O=C([O-])O.[Na+],val
US20030096788A1,CCC(O)CN.CCOCC.OC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O.c1occ2c1OCO2>>CCC(O)CNC(=O)[C@H]1O[C@@H](OC)[C@@H]2OC(C)(C)O[C@H]21,,CCOCC,ClCCl,O=C(c1ncc[nH]1)c1ncc[nH]1,,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([C@H](O)c4cccc[n+]4[O-])cc2)CCN3)cc1.Cc1cc(C=O)sn1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([C@H](O)c4cccc[n+]4[O-])cc2)CCN3Cc2cc(C)ns2)cc1,,ClCCCl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20020110650A1,Nc1ccc2c(c1)sc1cc(Br)ccc12.O=N[O-]>>Oc1ccc2c(c1)sc1cc(Br)ccc12,,O,,O=S(=O)(O)O,,val
US20120277477A1,CCOC(=O)CC(OCC)OCC>>CCOC(CCO)OCC,,O,,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05525632,COc1cc(/C(C#N)=C\c2ccc(Cl)c([N+](=O)[O-])c2)cc(OC)c1OC>>COc1cc(/C(C#N)=C\c2ccc(Cl)c(N)c2)cc(OC)c1OC,[Zn],CC(=O)O,,,,val
US06265434B1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1cccc2nonc12>>O=S(=O)(Oc1cccc2nonc12)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US20090247507A1,CN(C)c1ccc(C=O)cc1.Nc1ncc(Cl)c(N2CCN(CC(=O)Nc3nccs3)CC2)c1[N+](=O)[O-]>>CN(C)c1ccc(-c2nc3c(N4CCN(CC(=O)Nc5nccs5)CC4)c(Cl)cnc3[nH]2)cc1,,CCO,,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20160083365A1,CC(=O)OC(C)=O.Nc1ccnc(Cl)n1>>CC(=O)Nc1ccnc(Cl)n1,,CN(C)C=O,,[H-].[Na+],,val
US20090076070A1,NC(=O)c1ccc2nc[nH]c2c1>>N#Cc1ccc2nc[nH]c2c1,,CN(C)C=O,,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US20090118263A1,CC(C)(C)OC(=O)N1CCC2(CC1)CNCCO2.COC(=O)Cc1cccc(OCCBr)c1>>COC(=O)Cc1cccc(OCCN2CCOC3(CCN(C(=O)OC(C)(C)C)CC3)C2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05712267,CC(C)(C)OC(=O)N1CCNCC1.COc1ccc(CS[C@H]2C[C@@H](C(=O)O)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1>>COc1ccc(CS[C@H]2C[C@@H](C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1,,CC#N,,,,val
US20110034433A1,CC1=C(C(=O)O)C(c2ccc(C#N)cc2S(=O)(=O)CCO)NC(=O)N1c1cccc(C(F)(F)F)c1.[NH4+]>>CC1=C(C(N)=O)C(c2ccc(C#N)cc2S(=O)(=O)CCO)NC(=O)N1c1cccc(C(F)(F)F)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3nc(C(F)(F)F)[nH]c3c2)cc1.Cl>>Cc1cc(C(=O)NC2CCNCC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc3nc(C(F)(F)F)[nH]c3c2)cc1.Cl,,C1CCOC1,C1COCCO1,,,val
US05780607,Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1N.O=C(OCC1c2ccccc2-c2ccccc21)ON1C(=O)CCC1=O>>Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(=O)OCC1c2ccccc2-c2ccccc21,,C1COCCO1,,O,O=C([O-])O.[Na+],val
US20100234345A1,CC1(C(=O)O)CCC(C(=O)O)C1(C)C.CCCCc1cn(C(C)(C)C)sc1=N.N>>CCCCc1cn(C(C)(C)C)s/c1=N\C(=O)[C@H]1CC[C@@](C)(C(N)=O)C1(C)C,,CO,,,,val
US05693628,CO.O=C([O-])O.O=Cc1ccc(Br)cc1>>COC(OC)c1ccc(Br)cc1,,O=S(Cl)Cl,,,,val
US06136823,N.Nc1cc(-n2cc(C(=O)O)c(=O)c3cc([N+](=O)[O-])c(F)cc32)c(F)cc1F>>Nc1cc(-n2cc(C(=O)O)c(=O)c3cc([N+](=O)[O-])c(N)cc32)c(F)cc1F,,c1ccncc1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US04567052,CC(=O)Cl.N#Cc1c[nH]cc1-c1ccc(Cl)cc1Cl.O=CC(Cl)(Cl)Cl>>CC(=O)OC(n1cc(C#N)c(-c2cccc(Cl)c2Cl)c1)C(Cl)(Cl)Cl,CN(C)c1ccncc1,,,C1CCOC1,CCN(CC)CC,val
US05684034,CCOC(=O)CCCOc1ccc2c(c1)c(CC(N)=O)c(SC)n2Cc1ccccc1>>CSc1c(CC(N)=O)c2cc(OCCCC(=O)O)ccc2n1Cc1ccccc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US04888340,Cc1ccc(S(=O)(=O)OCC(F)(F)F)cc1.O=C(Cc1ccccc1)c1ccc(O)cc1>>O=C(Cc1ccccc1)c1ccc(OCC(F)(F)F)cc1,,CN(C)C=O,CS(C)=O,[I-].[K+],O=C([O-])O.[Na+],val
US20150175601A1,CC(C)(C)C(=O)Cl.CC(C)(C)OC(=O)N1CCC(Oc2ccc(N)c(F)c2)CC1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(NC(=O)C(C)(C)C)c(F)c2)CC1,,C1CCOC1,CCOC(C)=O,,,val
US20060178359A1,CCOC(=O)CCCCBr.c1ccc2c(c1)CCCN2>>CCOC(=O)CCCCN1CCCc2ccccc21,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20060128685A1,CCOC(=O)c1cc(-c2cc(OC)ccn2)n(-c2ccc(Cl)nn2)n1.CO>>COc1ccnc(-c2cc(C(=O)O)nn2-c2ccc(OC)nn2)c1,,CO,,C1CCOC1,[Na+].[OH-],val
US20140221393A1,CCCCCCCCn1ncn(-c2ccc(N3CCN(c4ccc(OC)cc4)CC3)cc2)c1=O>>CCCCCCCCn1ncn(-c2ccc(N3CCN(c4ccc(O)cc4)CC3)cc2)c1=O,,Br,,,,val
US20120289526A1,COc1ccc(C)c(O)c1.O=[N+]([O-])c1ccc(Cl)nc1>>COc1ccc(C)c(Oc2ccc([N+](=O)[O-])cn2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04946863,CCCN=C=O.CCN(CC)CC1CCc2ccc(O)cc21>>CCCNC(=O)Oc1ccc2c(c1)C(CN(CC)CC)CC2,,Cc1ccccc1,,CC(=O)O,,val
US20080161294A1,BrCc1ccccc1.CC(C)(C)OC(=O)N1Cc2ccccc2NC[C@H]1CO>>CC(C)(C)OC(=O)N1Cc2ccccc2NC[C@H]1COCc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20120015962A1,COc1ccc(C)c(NC(C)=O)c1.O=[N+]([O-])O>>COc1cc(NC(C)=O)c(C)cc1[N+](=O)[O-],,CC(=O)O,,O=S(=O)(O)O,,val
US20140171403A1,CC(C)(C)OC(=O)NCCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1.CI>>CN(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)C(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US05371101,CC(=N)N.NNC(=O)Nc1ccc(OC(F)(F)C(F)F)cc1>>Cc1n[nH]c(=O)n1-c1ccc(OC(F)(F)C(F)F)cc1,,CN(C)C=O,,CC(=O)O,Cl,val
US20110288084A1,O=C1COc2ccc(CN[C@@H]3CC[C@@H](C(Cn4c(=O)ccc5ncc(F)cc54)NS(=O)(=O)c4ccccc4[N+](=O)[O-])CC3)nc2N1.Sc1ccccc1>>NC(Cn1c(=O)ccc2ncc(Sc3ccccc3)cc21)[C@@H]1CC[C@@H](NCc2ccc3c(n2)NC(=O)CO3)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140219989A1,CC(=O)OC(C(=O)OC(C)(C)C)c1cccc(Br)c1.OB(O)c1ccc(OC(F)(F)F)cc1>>CC(=O)OC(C(=O)OC(C)(C)C)c1cccc(-c2ccc(OC(F)(F)F)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100130506A1,CSC(=N)NC(=O)c1nc(Cl)c(N)nc1N.NCCCN>>Nc1nc(N)c(C(=O)N=C2NCCCN2)nc1Cl,,CC(C)O,,,,val
US03999974,CC(=O)C1C(=O)N(C)C(=O)N(C)C1=O.CCON>>CCONC(C)=C1C(=O)N(C)C(=O)N(C)C1=O,,CCO,,,,val
US20150005279A1,Nc1cccc(Br)c1C(=O)O>>Nc1cccc(Br)c1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030220375A1,COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)OC(C)(C)C)CC2)cc1>>C[C@@H](NC(=O)C1(N)CC1)c1ccc(-c2cccc(F)c2C(=O)O)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100125061A1,COC(=O)Cc1cc2ccc(F)cc2c(C(=O)O)c1C.Fc1ccc(N2CCNCC2)cc1>>COC(=O)Cc1cc2ccc(F)cc2c(C(=O)N2CCN(c3ccc(F)cc3)CC2)c1C,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20090215767A1,COc1ccc(-c2coc3cc(OCC4CO4)ccc3c2=O)cc1OC.NC1CCCCC1>>COc1ccc(-c2coc3cc(OCC(O)CNC4CCCCC4)ccc3c2=O)cc1OC,,CCO,,,,val
US20020169317A1,ClCCCBr.Oc1cccc2c1c1cccc3c1n2C(c1ccccc1)CO3>>ClCCCOc1cccc2c1c1cccc3c1n2C(c1ccccc1)CO3,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080293712A1,COc1cc2ncc3c(N)nc(-c4cncc(OCC5CN5C(=O)OC(C)(C)C)c4)cc3c2cc1OC.Oc1ccc(F)cc1F>>COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)COc5ccccc5F)c4)cc3c2cc1OC,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100056516A1,CCOC(=O)c1c(N)c2cccnc2n(OCc2ccccc2)c1=O>>CCOC(=O)c1c(N)c2cccnc2n(O)c1=O,[Pd],CCO,,,,val
US05034417,CC(=O)c1ccc(NS(C)(=O)=O)c(Nc2ccc(F)cc2F)c1>>CC(O)c1ccc(NS(C)(=O)=O)c(Nc2ccc(F)cc2F)c1,,CO,,CC(=O)O,[BH4-].[Na+],val
US04312876,CCOC(=O)Cl.COc1cccc(O[C@@H]2CCN(C)C[C@H]2c2ccccc2)c1>>CCOC(=O)N1CC[C@@H](Oc2cccc(OC)c2)[C@H](c2ccccc2)C1,,c1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20090099213A1,Clc1ncnc2nc[nH]c12.NC(c1ccc(Cl)cc1)C1CCNCC1>>NC(c1ccc(Cl)cc1)C1CCN(c2ncnc3[nH]cnc23)CC1,,CCCCO,,,,val
US20160214971A1,CS(=O)(=O)NC(=O)c1ccc(-c2cnc(F)c(Cl)c2)c(Br)c1.Cc1cc(Cl)cc(Cl)c1O>>Cc1cc(Cl)cc(Cl)c1Oc1ncc(-c2ccc(C(=O)NS(C)(=O)=O)cc2Br)cc1Cl,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140134235A1,CCOC=O.FC(F)(F)c1cccc2ccc(Cl)nc12>>O=Cc1cc2cccc(C(F)(F)F)c2nc1Cl,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20140206681A1,CC1(C)OB(c2ccc(C(N)=O)cc2)OC1(C)C.FC(F)c1ccnc(Br)c1>>CC1(C)OB(c2ccc(C(=O)Nc3cc(C(F)F)ccn3)cc2)OC1(C)C,,C1COCCO1,,CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1,O=C([O-])[O-].[Cs+].[Cs+],val
US20100029650A1,CC(C)OC(=O)N1CCC(COc2ccc(Br)nc2)CC1.O=S(=O)(NCCO)c1ccc(B(O)O)cc1>>CC(C)OC(=O)N1CCC(COc2ccc(-c3ccc(S(=O)(=O)NCCO)cc3)nc2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20080119466A1,CC(=O)OC(C)=O.N=C(NO)c1ccc2c(ccn2-c2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)c1>>Cc1nc(-c2ccc3c(ccn3-c3ccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)cc3)c2)no1,,c1ccncc1,,,,val
US20110150834A1,Cc1c(Cc2ccccc2S(=O)(=O)N2CCOCC2)c(C(O)C(F)(F)F)c(-c2ccccc2)n1CC(=O)O>>Cc1c(Cc2ccccc2S(=O)(=O)N2CCOCC2)c(CC(F)(F)F)c(-c2ccccc2)n1CC(=O)O,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US04939161,COC(=O)C1CN(Cc2ccccc2)CC(C)C1=O.Nc1ccccc1>>COC(=O)C1CN(Cc2ccccc2)CC(C)C1Nc1ccccc1,,CO,,Cl,[BH3-]C#N.[Na+],val
US20140051672A1,COc1cc(-n2cccn2)ccc1-c1ccc(OC2CCN(C(=O)OC(C)(C)C)C2)nn1>>COc1cc(-n2cccn2)ccc1-c1ccc(OC2CCNC2)nn1,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20070106095A1,CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1cc2ccc(O)cc2o1.CS(=O)(=O)Cl>>CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1cc2ccc(OS(C)(=O)=O)cc2o1,,ClCCl,,CCN(CC)CC,,val
US20150111891A1,Cc1ccc(S(=O)(=O)OC[C@H](O)c2c(C)cc3ccccc3c2Cl)cc1>>Cc1cc2ccccc2c(Cl)c1[C@@H]1CO1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20140357637A1,N=C(N)c1nn(Cc2ccccc2F)c2nc(C(F)(F)F)ccc12.NN>>N=C(NN)c1nn(Cc2ccccc2F)c2nc(C(F)(F)F)ccc12,,CCO,,O,,val
US20040082611A1,O=C=O.[Li]CCCC.c1cc(-c2cncs2)ccn1>>O=C([O-])c1ncc(-c2ccncc2)s1.[Li+],,CCOCC,,CCCCCC,,val
US20160060260A1,CC(C)CCOc1cccc(Oc2cc3c(cc2N)n(C)c(=O)n3C)c1.Cc1nc(S(=O)(=O)Cl)cn1C>>Cc1nc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCCC(C)C)c2)n(C)c(=O)n3C)cn1C,,ClCCl,,c1ccncc1,,val
US20090105474A1,C=CB1OC(C)(C)C(C)(C)O1.CC(C)(C)OC(=O)c1ccc(Br)cc1Nc1ccc(F)cc1>>C=Cc1ccc(C(=O)OC(C)(C)C)c(Nc2ccc(F)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20160009744A1,Cc1sc(C=O)nc1CBr.OB(O)c1cccc(Br)c1>>Cc1sc(C=O)nc1Cc1cccc(Br)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US05801201,COc1cccc(C2(O)CCC3(CC2CN(C)C)OCCO3)c1>>COc1cccc(C2(O)CCC(=O)CC2CN(C)C)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20050250823A1,BrBr.COC(=O)C(O)=Cc1cccnc1>>Br.COC(=O)C(=O)C(Br)c1cccnc1,,C1CCOC1,,CO,,val
US04451551,CN(C)CCO.[N-]=[N+]=Nc1ccc(C=CC(=O)Cl)cc1>>CN(C)CCOC(=O)C=Cc1ccc(N=[N+]=[N-])cc1,,ClC(Cl)(Cl)Cl,,,,val
US20160102083A1,COC(=O)c1csc(N2CCCC2C)c1C>>Cc1c(C(=O)O)csc1N1CCCC1C,,CO,,[Na+].[OH-],,val
US20080015199A1,COC(=O)N=C(SC)C(=Nc1ccc(C#N)cc1)c1cc(OC)c2c(c1F)OCCO2.COC(=O)c1sccc1NN>>COC(=O)c1sccc1-n1nc(C(Nc2ccc(C#N)cc2)c2cc(OC)c3c(c2F)OCCO3)[nH]c1=O,,CN(C)C=O,,CCN(CC)CC,,val
US20070173532A1,C=C[C@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1CCO.Sc1nnnn1-c1ccccc1>>C=C[C@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1CCSc1nnnn1-c1ccccc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080124384A1,C[C@@H]1CCCN1.Cn1ccnc1N1CCN(c2cc(-c3ccc(F)c(Cl)c3)nc(Cl)n2)CC1>>C[C@@H]1CCCN1c1nc(-c2ccc(F)c(Cl)c2)cc(N2CCN(c3nccn3C)CC2)n1,,CC(=O)N(C)C,,Cl,,val
US20110130404A1,Nc1cccc(O)c1N.O=C(C(=O)n1ccnc1)n1ccnc1>>O=c1[nH]c2cccc(O)c2[nH]c1=O,,C1CCOC1,,,,val
US04195041,Nc1ccc(C=O)cc1.O=S(=O)(O)O>>O=Cc1ccc(O)cc1,,CN(C)C=O,,,,val
US20160009726A1,C[C@H]1CN(c2ccncc2N)C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C.O=C(O)c1ccc2cc(C3CC3)oc2n1>>C[C@H]1CN(c2ccncc2NC(=O)c2ccc3cc(C4CC4)oc3n2)C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100249119A1,COc1ccc(N)cc1Oc1ccc2nc(NC(=O)C3CC3)sc2n1.O=C(Cl)c1cccc(C(F)(F)F)c1>>COc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Oc1ccc2nc(NC(=O)C3CC3)sc2n1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20020037887A1,O=C1NC(=O)c2ccccc21.O=[N+]([O-])c1ccc2[nH]ccc2c1>>NC(=O)C(=O)c1c[nH]c2ccc([N+](=O)[O-])cc12,,CCOCC,,O=C(Cl)C(=O)Cl,,val
US20130029962A1,COc1cccnc1O.O=[N+]([O-])O>>COc1cc([N+](=O)[O-])cnc1O,,O=S(=O)(O)O,,,,val
US05716953,Nc1ccccc1[N+](=O)[O-].O=C(Cl)C12CC3CC(CC(C3)C1)C2>>O=C(Nc1ccccc1[N+](=O)[O-])C12CC3CC(CC(C3)C1)C2,,CC(C)=O,,CCN(CC)CC,,val
US20140113882A1,COC(=O)[C@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)[C@@H](C(=O)O)C1,,CCO,,[K+].[OH-],,val
US20110112151A1,O=C(CBr)C12CC3CC(CC(C3)C1)C2.Oc1cncc(Cl)c1>>O=C(COc1cncc(Cl)c1)C12CC3CC(CC(C3)C1)C2,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080221114A1,C=CB1OC(C)(C)C(C)(C)O1.C[C@H]1CCCN(C(=O)[C@H]2Cc3cc(Br)ccc3N2c2cccnn2)C1>>C=Cc1ccc2c(c1)C[C@H](C(=O)N1CCC[C@H](C)C1)N2c1cccnn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20110152237A1,COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc(-c3ccc(-c4c[nH]c([C@@H]5CC6(CN5C(=O)OCc5ccccc5)OCCCO6)n4)cc3)cc2)c[nH]1)C(C)C>>COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc(-c3ccc(-c4c[nH]c([C@@H]5CC6(CN5)OCCCO6)n4)cc3)cc2)c[nH]1)C(C)C,[Pd],CCO,,,,val
US20090170894A1,O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=S(=O)(OC1=CC2CCC(C1)N2)C(F)(F)F.c1ccc2c(c1)CCCN2>>O=C(N1CCCc2ccccc21)N1C2C=C(OS(=O)(=O)C(F)(F)F)CC1CC2,,CCN(CC)CC,ClCCl,Cl,O=C([O-])O.[Na+],val
US20150374849A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1(C)CCNC(=O)CC1>>CC1(C)CCC(=O)N(C(=O)OC(C)(C)C)CC1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20110144105A1,COc1cnc2c(c1)cc(C(=CC1CCOCC1)OS(=O)(=O)c1ccc(C)cc1)n2S(=O)(=O)c1ccccc1.OB(O)c1ccc(C(F)(F)F)cc1>>COc1cnc2c(c1)cc(C(=CC1CCOCC1)c1ccccc1C(F)(F)F)n2S(=O)(=O)c1ccccc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20160159808A1,Cc1cn2ncc(C(=O)OC(C)(C)C)c2nc1O.ClC(Cl)(Cl)Cl>>Cc1cn2ncc(C(=O)OC(C)(C)C)c2nc1Cl,,ClCCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120258949A1,O=C(/C=C/c1ccc2c(c1)C(=O)NC1(CCCN(Cc3ccccc3)C1)O2)NOC1CCCCO1>>O=C(/C=C/c1ccc2c(c1)C(=O)NC1(CCCN(Cc3ccccc3)C1)O2)NO,,C1COCCO1,ClCCl,Cl,,val
US20030018200A1,CSSC.Cc1cccc([N+](=O)[O-])c1N>>CSc1c(C)cccc1[N+](=O)[O-],[Cu],,,CC(C)(C)ON=O,,val
US20140171388A1,CCCCCCCCCCCCCCCCCCN(C)CCO.ClCCCl.O=S(Cl)Cl>>CCCCCCCCCCCCCCCCCC[NH+](C)CCCl.[Cl-],,ClCCCl,,,,val
US04521325,NNCCO.O=C=NC1CCCCC1>>NN(CCO)C(=O)NC1CCCCC1,,C1CCOC1,,,,val
US04009177,COc1cc(C=NO)c([N+](=O)[O-])cc1OC.ClCc1ccccc1>>COc1cc(C=NOCc2ccccc2)c([N+](=O)[O-])cc1OC,,CN(C)C=O,,C[O-].[Na+],,val
US20140031360A1,CC(C)(C)OC(=O)n1cc(I)c2cc(C(N)=O)ccc21.CCCC[Sn](CCCC)(CCCC)c1cncc(N2CCC(NC(=O)OC(C)(C)C)CC2)n1>>CC(C)(C)OC(=O)NC1CCN(c2cncc(-c3cn(C(=O)OC(C)(C)C)c4ccc(C(N)=O)cc34)n2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20030087907A1,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Cc1nnc(N)s1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4nnc(C)s4)cc3)c2cc1OC,,ClC(Cl)Cl,O,CCN(C(C)C)C(C)C,,val
US04988814,CC(C)(C)C(=O)Cl.COc1ccccc1N1CCN(CCCO)CC1>>COc1ccccc1N1CCN(CCCOC(=O)C(C)(C)C)CC1,,ClCCl,,CCN(CC)CC,,val
US05411980,CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1.CCCN=C=O>>CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1,CN(C)c1ccncc1,c1ccncc1,,,,val
US04482556,CCCCO.COc1cc2c(cc1OC)-c1cc(Cl)nc(=O)n1CC2>>CCCCOc1cc2n(c(=O)n1)CCc1cc(OC)c(OC)cc1-2,,CCCCO,,[Na+].[OH-],,val
US20040167123A1,CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(N)ccc3N2)c(O)c2cccnc21.CCCCS(=O)(=O)Cl>>CCCCS(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(c1c(O)c3cccnc3n(CCC(C)C)c1=O)N2,,c1ccncc1,,,,val
US20040034004A1,CC1(C)COc2ccc(Br)cc21.CN(C)C=O>>CC1(C)COc2ccc(C=O)cc21,,C1CCOC1,,O,[Li]CCCC,val
US05929098,CON=Cc1cc(C(=O)[O-])cc(Cl)c1N>>CON=Cc1cc(C(=O)O)cc(Cl)c1N,,O,,CO,[Na+].[OH-],val
US04266014,CCOC(=O)CC(C)=O.NNCC(F)(F)F>>CC1=NN(CC(F)(F)F)C(=O)C1,,CC(=O)O,,O,,val
US20100331297A1,CC(C)(C)n1nc(Br)c2c(N)ncnc21.OB(O)c1cc2ccccc2s1>>CC(C)(C)n1nc(-c2cc3ccccc3s2)c2c(N)ncnc21,,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US20150284411A1,CS(=O)(=O)c1nc2cc(Cl)ncc2[nH]1.C[Si](C)(C)CCOCCl>>C[Si](C)(C)CCOCn1c(S(C)(=O)=O)nc2cc(Cl)ncc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20100256188A1,CNc1ccc(C(=O)Nc2ccc(Br)cc2)cc1NC(=S)Nc1cc(C(C)NC(C)=O)ccc1Cl>>CC(=O)NC(C)c1ccc(Cl)c(Nc2nc3cc(C(=O)Nc4ccc(Br)cc4)ccc3n2C)c1,,CN(C)C=O,,CC(C)N=C=NC(C)C,,val
US20150105370A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC(=O)O.c1ccc(COC[C@H]2CO2)cc1>>CC(C)(C)OC(=O)N(CC(=O)O)C[C@@H](O)COCc1ccccc1,,C1COCCO1,,[Na+].[OH-],,val
US20110172219A1,C[C@H]1COc2c(F)c(F)c([N+](=O)[O-])c3c(=O)c(C(N)=O)cn1c23>>C[C@H]1COc2c(F)c(F)c(N)c3c(=O)c(C(N)=O)cn1c23,,CO,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20100305131A1,COC(=O)c1ccc(N)nc1.CS(=O)(=O)Cl>>CS(=O)(=O)Nc1ccc(C(=O)O)cn1,,ClCCl,,Cl,[Na+].[OH-],val
US20020169192A1,CCCCCCCN(CCc1cccc(CC(OCC)C(=O)OC)c1)C(=O)Nc1ccc(OC)cc1OC>>CCCCCCCN(CCc1cccc(CC(OCC)C(=O)O)c1)C(=O)Nc1ccc(OC)cc1OC,,C1CCOC1,,[Li+].[OH-],,val
US20040186301A1,CC(C)(C)OC(=O)CBr.COC(=O)C(CCc1ccccc1)CC(=O)N1C(=O)OCC1Cc1ccccc1>>COC(=O)C(CCc1ccccc1)C(CC(=O)OC(C)(C)C)C(=O)N1C(=O)OCC1Cc1ccccc1,,C1CCOC1,,,,val
US04810719,CC(=O)OC(C)=O.Oc1ccc(Nc2ccn(-c3ccccc3)n2)cc1>>CC(=O)Oc1ccc(Nc2ccn(-c3ccccc3)n2)cc1,,O,,O=S(=O)(O)O,,val
US20140364432A1,C[C@@H]1CCCN[C@@H]1CNC(=O)OC(C)(C)C.Cc1ccc(-c2cccc(C)n2)c(C(=O)O)c1>>Cc1ccc(-c2cccc(C)n2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNC(=O)OC(C)(C)C)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US04132677,N#CCC(=O)O.O=CC1CC2C=CC1C2>>N#CCC=C1CC2C=CC1C2,,c1ccccc1,,[NH4+].[OH-],,val
US05627205,CCOC(=O)C(C)(C)Oc1ccc(CCOc2cc(C)c(OC(C)=O)c(C)c2C)cc1>>Cc1cc(OCCc2ccc(OC(C)(C)C(=O)O)cc2)c(C)c(C)c1O,,CCO,,[Na+].[OH-],,val
US20090156600A1,Cc1nc2c(Cl)ccc(O)c2c(C)c1Oc1ccc(Cl)cc1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1nc2c(Cl)ccc(OS(=O)(=O)C(F)(F)F)c2c(C)c1Oc1ccc(Cl)cc1,,ClCCl,,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US20130344023A1,CC(C)(C)OC(=O)NCCO.CC(C)Cc1ccc(C(C)C(=O)O)cc1>>CC(C)Cc1ccc(C(C)C(=O)OCCNC(=O)OC(C)(C)C)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04851526,CC(O)CCN1CCOCC1.O=[N+]([O-])c1ccc(F)cc1>>CC(CCN1CCOCC1)Oc1ccc([N+](=O)[O-])cc1,,O,,CN(C)C=O,[H-].[Na+],val
US20100130739A1,Cc1nc(OCC(=O)N(C)C2CCN(Cc3ccccc3)CC2)nc(C)c1NC(=O)OC(C)(C)C>>Cc1nc(OCC(=O)N(C)C2CCNCC2)nc(C)c1NC(=O)OC(C)(C)C,[Pd],CO,,,,val
US20020143009A1,CC(=O)OC(C)=O.CC(C)(C)[Si](C)(C)OCC1Cc2cc(N3CC(CN)OC3=O)ccc2N1C(=O)OCc1ccccc1>>CC(=O)NC[C@H]1CN(c2ccc3c(c2)CC(CO[Si](C)(C)C(C)(C)C)N3C(=O)OCc2ccccc2)C(=O)O1,,c1ccncc1,,,,val
US05134111,COC(Cl)Cl.Cc1cccc2ccc(C(C)C)c(O)c12.O>>Cc1cccc2c(C=O)cc(C(C)C)c(O)c12,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20080139639A1,CN.Cl.N#Cc1ccccc1S(=O)(=O)n1cc(C=O)cc1-c1ccccc1F>>CNCc1cc(-c2ccccc2F)n(S(=O)(=O)c2ccccc2C#N)c1.Cl,,CO,,[BH4-].[Na+],,val
US04607041,CCOC(=O)C(=Cc1cccc([N+](=O)[O-])c1)C(=O)CF.CCOC(=O)C=C(N)N>>CCOC(=O)C1=C(N)NC(CF)=C(C(=O)OCC)C1c1cccc([N+](=O)[O-])c1,,CCO,,Cl,[Na],val
US04401673,CC(=O)OC(C)=O.COC(=O)[C@@H]1[C@@H](C=CC(O)C(Cl)(Cl)Cl)C1(C)C>>COC(=O)[C@@H]1[C@@H](C=CC(OC(C)=O)C(Cl)(Cl)Cl)C1(C)C,,Cl,,c1ccncc1,,val
US20160185778A1,CCOC(=O)C[C@H](C)N(CCC(=O)C1CCCO1)C(=O)OC(C)(C)C>>C[C@H]1CC(=O)C(C(=O)C2CCCO2)CN1C(=O)OC(C)(C)C,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20120184525A1,N#Cc1c(N2CCC(c3ccccc3)CC2)ccnc1Br.NN>>N#Cc1c(N2CCC(c3ccccc3)CC2)ccnc1NN,,C1CCOC1,,O,,val
US20070049593A1,COC(=O)c1ccc2c(C3CCCCC3)c(-c3cccn3C(=O)OC(C)(C)C)n(CCCCl)c2c1>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc[nH]3)n(CCCCl)c2c1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20090062348A1,N#Cc1ccc2oc(COc3ccccc3)cc2c1>>NCc1ccc2oc(COc3ccccc3)cc2c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04039316,C=C1CC(=O)O1.CCC(=O)Nc1cccc(N)c1>>CCC(=O)Nc1cccc(NC(=O)CC(C)=O)c1,,c1ccccc1,,,,val
US20020095050A1,CCCNC(=O)Nc1cccc(-c2cccc(OC[C@H](NC(c3ccccc3)(c3ccccc3)c3ccccc3)C(=O)OC)c2)c1.Cl>>CCCNC(=O)Nc1cccc(-c2cccc(OC[C@H](N)C(=O)OC)c2)c1.Cl,,CCOCC,CO,,,val
US07071207B2,COc1ccc(-c2cc3c(n2-c2ccccc2Cl)CCNC3)cc1.O=Cc1ccc(F)cc1>>COc1ccc(-c2cc3c(n2-c2ccccc2Cl)CCN(Cc2ccc(F)cc2)C3)cc1,,ClCCl,,CC(=O)O,[Na+].[OH-],val
US20160185752A1,CO.Cc1cc(Cl)ccc1C1CCCN(C(=O)c2cnnc(Cl)c2)C1>>COc1cc(C(=O)N2CCCC(c3ccc(Cl)cc3C)C2)cnn1,,CO,,C[O-].[Na+],,val
US20060276498A1,N#Cc1cnc2cnc(F)cc2c1NC1CCCC1.Nc1ccc(F)c(Cl)c1>>N#Cc1cnc2cnc(Nc3ccc(F)c(Cl)c3)cc2c1NC1CCCC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140088080A1,CC(=O)CBr.COC(=O)c1cnc(N)c(OCc2ccccc2F)c1>>COC(=O)c1cc(OCc2ccccc2F)c2nc(C)cn2c1,,CCO,,O=C([O-])O.[Na+],,val
US20160244441A1,CN.Nc1cc(Cl)ccn1>>CNc1ccnc(N)c1,,O,,,,val
US20040180939A1,CCc1ccc2c(c1)C(NCC(O)C(N)Cc1cc(F)cc(F)c1)CCC2.O=C1CCCC(=O)O1>>CCc1ccc2c(c1)[C@@H](NC[C@@H](O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)CCCC(=O)O)CCC2,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20110046169A1,CCOC(=O)CC#N.Cc1cc(F)ccc1N>>Cc1cc(F)ccc1NC(=O)CC#N,,CCCCCC,CCOC(C)=O,,,val
US04540703,CNC1CCCCC1.O=C(Cl)CCCCl>>CN(C(=O)CCCCl)C1CCCCC1,,O,,CCN(CC)CC,CCOC(C)=O,val
US20070149608A1,Cc1cc(O)cc(C)c1-c1cccc(COC2CCCCO2)c1.OCc1ccccc1>>Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COC2CCCCO2)c1,,CCCCCC,Cc1ccccc1,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20120148502A1,CC(=O)OCC1OC(O)C(OC2OC(OC(C)=O)C(OC(C)=O)C(OC(N)=O)C2OC(C)=O)C(OC(C)=O)C1OC(C)=O.O=P(Cl)(Oc1ccccc1)Oc1ccccc1>>CC(=O)OCC1OC(OP(=O)(Oc2ccccc2)Oc2ccccc2)C(OC2OC(OC(C)=O)C(OC(C)=O)C(OC(N)=O)C2OC(C)=O)C(OC(C)=O)C1OC(C)=O,,C1CCOC1,CCOC(C)=O,[Li]CCCC,O=C([O-])O.[Na+],val
US20120184508A1,C[Si](C)(C)CCOCn1nc(-c2cccc(NCc3ccccc3)n2)c2cnc(NCCN3CCCCC3)nc21>>c1ccc(CNc2cccc(-c3n[nH]c4nc(NCCN5CCCCC5)ncc34)n2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100009975A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCCCN1CCSc2cc([N+](=O)[O-])ccc21>>CN(CCCN1CCSc2cc([N+](=O)[O-])ccc21)C(=O)OC(C)(C)C,,C1COCCO1,,CCN(CC)CC,,val
US20120165343A1,CI.O=C(O)c1ccc(F)nc1>>COC(=O)c1ccc(F)nc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050080096A1,N=C(N)CCCN1CC=C(c2ccc(F)cc2)CC1.O=c1[nH]c2ncccc2c(=O)o1>>O=c1[nH]c(CCCN2CC=C(c3ccc(F)cc3)CC2)nc2ncccc12,,c1ccncc1,,,,val
US20050288273A1,CCOC(=O)Nc1cnc2c(c1)CCCCC2OC(=O)OC>>CCOC(=O)Nc1cnc2c(c1)CCCCC2O,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20060211740A1,CCOC(=O)c1cc(NC(=O)OCc2ccccc2)c2[nH]cc(CC)c2c1>>CCOC(=O)c1cc(N)c2[nH]cc(CC)c2c1,[Pd],CCO,,O,,val
US04000164,CCCCCCCC/C=C\CCCCCCCCOc1cc(C(=O)Cl)co1.COC(=O)CC(C)=O>>CCCCCCCC/C=C\CCCCCCCCOc1cc(C(=O)C(C(C)=O)C(=O)OC)co1,,c1ccccc1,,[Na],,val
US20100102716A1,Cc1cccc(B(O)O)c1.Fc1ccc2nc(Cl)ccc2c1>>Cc1cccc(-c2ccc3cc(F)ccc3n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,O,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20100168188A1,C=CC(C)=O.O=C1c2ccc3nn(Cc4ccccc4)cc3c2CC1CCF>>CC(=O)CCC1(CCF)Cc2c(ccc3nn(Cc4ccccc4)cc23)C1=O,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20030220324A1,CC(C)(C)OC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccn2)CC1>>O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccn2)CC1)[C@@H]1Cc2ccccc2CN1,,CCOC(C)=O,,Cl,,val
US05280010,NOc1ccc([N+](=O)[O-])cc1[N+](=O)[O-].O=c1cc(C(F)(F)F)[nH]c(=O)n1-c1cc(OCCF)c(Br)cc1F>>Nn1c(C(F)(F)F)cc(=O)n(-c2cc(OCCF)c(Br)cc2F)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20090105259A1,O=C=NC1CCCCC1.O=S(=O)(NCCCCNCCOCc1ccccc1)c1ccc(Cl)cc1Cl>>O=C(NC1CCCCC1)N(CCCCNS(=O)(=O)c1ccc(Cl)cc1Cl)CCOCc1ccccc1,,ClCCl,,,,val
US20060058372A1,CCN=C=O.OCCc1ccc(Br)cc1>>CCNC(=O)OCCc1ccc(Br)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04472404,CCOC(=O)CN=C=O.Oc1c(Br)cc(Br)c2cccnc12>>CCOC(=O)CNC(=O)Oc1c(Br)cc(Br)c2cccnc12,,Cc1ccccc1,,CCN(CC)CC,,val
US20040171622A1,CC(C)(C)[Si](C)(C)Oc1cccc(I)c1.CCN(CC)C(=O)c1ccc(C=O)cc1>>CCN(CC)C(=O)c1ccc(C(O)c2cccc(O[Si](C)(C)C(C)(C)C)c2)cc1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20090181963A1,Nc1ccc(-c2nc(N3CCOCC3)c3nnn(CC(F)(F)F)c3n2)cc1.Nc1ccc(CCO)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(Nc1ccc(CCO)cc1)Nc1ccc(-c2nc(N3CCOCC3)c3nnn(CC(F)(F)F)c3n2)cc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20040014802A1,C1CCNCC1.O=C(CCl)Nc1n[nH]c2cc(Cl)ccc12>>O=C(CN1CCCCC1)Nc1n[nH]c2cc(Cl)ccc12,,CC#N,,,,val
US06476059B1,O=C1CCc2cc(-c3cccnc3)ccc21.O=S(=O)(Cl)Cl>>O=C1c2ccc(-c3cccnc3)cc2CC1Cl,,ClCCl,,O=C([O-])O.[Na+],,val
US20090143353A1,Cc1c(C#N)c(O)c(NC(=O)C(C)(C)C)c(F)c1-c1ccccc1>>Cc1c(-c2ccccc2)c(F)c2nc(C(C)(C)C)oc2c1C#N,,Cc1ccccc1,,CCOC(C)=O,O=C([O-])O.[Na+],val
US20050182096A1,COC(=O)[C@H](CS(=O)(=O)Cc1cnccn1)NC(=O)OC(C)(C)C>>COC(=O)[C@@H](N)CS(=O)(=O)Cc1cnccn1,,C1CCOC1,,C1COCCO1,Cl,val
US20030073850A1,C=C(c1cccc([N+](=O)[O-])c1)c1cn(C(=O)OC(C)(C)C)cn1>>CC(c1cccc(N)c1)c1cn(C(=O)OC(C)(C)C)cn1,,CCOC(C)=O,,,,val
US20060183762A1,CCOC(=O)C1(COC)CCN(Cc2ccccc2)C1>>COCC1(CO)CCN(Cc2ccccc2)C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120040952A1,CC(C)=O.Cc1ccc(C(=O)N2CC(C(=O)N3CCCNCC3)C2)cn1>>Cc1ccc(C(=O)N2CC(C(=O)N3CCCN(C(C)C)CC3)C2)cn1,[Pd],CCO,,,,val
US20110269975A1,CC(C)(C)OC(=O)N1CC[C@H](/C=C/c2cncc(OC3CCOCC3)c2)C1>>C(=C/[C@H]1CCNC1)\c1cncc(OC2CCOCC2)c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US05789609,C=CC(C)=O.CCOC(=O)C(C)C#N>>CCOC(=O)C(C)(C#N)CCC(C)=O,,Cc1ccccc1,,,,val
US05041462,CC(=O)OCC(=O)Cl.CCN(C)c1cccc(N)c1C#N>>CCN(C)c1cccc(NC(=O)COC(C)=O)c1C#N,,ClCCl,,O,c1ccncc1,val
US20060223829A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCNCC1>>CC(=O)N1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,,,val
US20060084680A1,CCOC(=O)C[C@@H]1CCc2cc(OCCCNc3nc(-c4ccc(OC)cc4)ccc3C(F)(F)F)ccc21>>COc1ccc(-c2ccc(C(F)(F)F)c(NCCCOc3ccc4c(c3)CC[C@H]4CC(=O)O)n2)cc1,,C1CCOC1,CO,O,[Li+].[OH-],val
US20070208078A1,C/C(=C\Cc1c(O)c(Cl)c(C)c(C=O)c1O)CC/C=C(\C)[C@@H]1CC(=O)C(C)(C)O1>>Cc1c(Cl)c(O)c(CCC(C)CCCC(C)C2CC(=O)C(C)(C)O2)c(O)c1C=O,[Pd],CCO,,[H][H],,val
US20040186108A1,CC(=O)Nc1ccc(C(=O)CBr)cc1F>>CC(=O)Nc1ccc(CCBr)cc1F,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US04298529,CCOC(C)(OCC)C(=NOC)C(=O)OC.O=S(=O)(Cl)Cl>>CCOC(CCl)(OCC)C(=NOC)C(=O)OC,,ClC(Cl)Cl,,O=C([O-])[O-].[K+].[K+],,val
US20020068827A1,Cc1c(-c2ccccc2)nc2ccccc2c1C(=O)NC(c1ccccc1)C(C)O>>CC(=O)C(NC(=O)c1c(C)c(-c2ccccc2)nc2ccccc12)c1ccccc1,,ClCCl,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US20040009995A1,CCOC(=O)CCC(=O)Cl.CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2N)c1>>CCOC(=O)CCC(=O)Nc1cccc(C)c1-c1cccc(S(=O)(=O)c2cc(C(=N)NC(=O)OC(C)(C)C)sc2SC)c1,,CCOC(C)=O,,C1CCOC1,,val
US20030181519A1,COc1ccc2cccc(N)c2c1.Cl>>COc1ccc2cccc(Cl)c2c1,,CC#N,,CC(C)(C)ON=O,,val
US20060135578A1,CCOP(=O)(CP(=O)(OCC)OCC)OCC.COC(=O)c1cccc(-c2nc(COc3ccc(COc4nn(-c5ccccc5)cc4C=O)cc3)c(C)o2)c1>>CCOP(=O)(/C=C/c1cn(-c2ccccc2)nc1OCc1ccc(OCc2nc(-c3cccc(C(=O)O)c3)oc2C)cc1)OCC,,O,,CN(C)C=O,[H-].[Na+],val
US06156700,Cn1c(C(F)(F)F)cc(=O)n(-c2ccc3snc(-c4ccccc4O)c3c2)c1=O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cn1c(C(F)(F)F)cc(=O)n(-c2ccc3snc(-c4ccccc4O)c3c2)c1=O.O=S(=O)(O)C(F)(F)F,,CCOCC,ClCCl,CCN(CC)CC,O,val
US20150218170A1,CC(NC(=O)OC(C)(C)C)c1cccc(Nc2cnc3c(n2)c(C(=O)NC(C)(C)C)cn3COCC[Si](C)(C)C)c1>>CC(N)c1cccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140094474A1,Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.Cn1cc(C(=O)OCc2ccccc2)nc1Br>>Cn1cc(-c2nc(C(=O)OCc3ccccc3)cn2C)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20160151337A1,Cc1cc(O)ncc1Br.ClC(Cl)Cl.S=C(Cl)Cl>>Cc1cc(OC(Cl)(Cl)Cl)ncc1Br,,[Na+],[OH-],,,val
US20010039344A1,ICC1CCCC1.O=C(O)Cc1ccc(Br)cc1>>O=C(O)C(CC1CCCC1)c1ccc(Br)cc1,,C1CCOC1,CN1CCCN(C)C1=O,CC(C)NC(C)C,[Li]CCCC,val
US20040102435A1,CN(C)C=O.COc1ccc(-c2nc3cc(OC)cc(Br)c3o2)cc1.N#C[Cu]>>NC(=O)c1cc(O)cc2nc(-c3ccc(O)cc3)oc12,,CCOC(C)=O,,,,val
US20100093757A1,Cc1ccc(NC(=O)[C@@H](O)COC(C)C)nc1.FC(F)(F)c1ccccc1-n1ncc2c(Oc3ccccc3)ncnc21>>Cc1ccc(NC(=O)[C@H](COC(C)C)Oc2ncnc3c2cnn3-c2ccccc2C(F)(F)F)nc1,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20150266862A1,CC(C)CI.COC(=O)c1cccc(S)c1>>COC(=O)c1cccc(SCC(C)C)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130345192A1,CN[C@@H]1CCCN(Cc2ccccc2)C1.Cc1ccc(S(=O)(=O)n2ccc3c(Cl)ncnc32)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c(N(C)[C@@H]4CCCN(Cc5ccccc5)C4)ncnc32)cc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20050245563A1,COC(=O)c1cc(F)ccc1[N+](=O)[O-]>>COC(=O)c1cc(F)ccc1N,[Pd],CO,,,,val
US20070082912A1,CC#N.CC(=O)CCC(=O)c1cc(F)ccc1OCc1ccc(F)cc1.COC(=O)c1cc(N)cc(N2CCCC2=O)c1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl>>CCCC(C)C.CCOC(C)=O.COC(=O)c1cc(N2CCCC2=O)cc(-n2c(C)ccc2-c2cc(F)ccc2OCc2ccc(F)cc2)c1,,CC#N,ClCCl,Cl,,val
US20150238558A1,COC(=O)[C@@H]1C[C@H](NC(=O)c2ccc(CN(C(=O)[C@@H]3Cc4ccccc4CN3C(=O)OCc3ccccc3)[C@H](C)c3ccccc3F)cc2)CN1C(=O)OC(C)(C)C>>C[C@H](c1ccccc1F)N(Cc1ccc(C(=O)N[C@H]2C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C2)cc1)C(=O)[C@@H]1Cc2ccccc2CN1C(=O)OCc1ccccc1,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US20110009405A1,FC(F)c1nc2ccccc2n1-c1nc(Cl)nc(N2CCOCC2)n1.NCc1ccccc1>>FC(F)c1nc2ccccc2n1-c1nc(NCc2ccccc2)nc(N2CCOCC2)n1,,C1COCCO1,O,,,val
US20120264777A1,C=C(OCC)c1ccc(F)c(C)n1.O=C1CCC(=O)N1Br>>Cc1nc(C(=O)CBr)ccc1F,,C1CCOC1,O,,,val
US20090042900A1,CC(C)(C)OC(=O)N1CCC(COc2cccc3nc(N)nc(N)c23)CC1>>Nc1nc(N)c2c(OCC3CCNCC3)cccc2n1,,C1COCCO1,,Cl,,val
US20090227591A1,CCOC(=O)c1cc(N)cc([N+](=O)[O-])c1.[I-]>>CCOC(=O)c1cc(I)cc([N+](=O)[O-])c1,,Cl,O,O=N[O-].[Na+],,val
US20130018055A1,[O-][n+]1cc(Br)cc2c1CCC2>>OC1CCc2cc(Br)cnc21,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20110028466A1,C=C(C)CO.ClCc1ccc(OCc2ccccc2)cc1>>C=C(C)COCc1ccc(OCc2ccccc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20040242589A1,CC(C)(C)OC(=O)N1CCN(c2c(Cl)ccc3c(S(=O)(=O)c4ccccc4)csc23)CC1.Cl>>Cl.O=S(=O)(c1ccccc1)c1csc2c(N3CCNCC3)c(Cl)ccc12,,C1COCCO1,,,,val
US20070259877A1,COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1C.Cc1csc(B(O)O)c1>>COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,CC(C)(C)[O-].[K+],,val
US05021429,CN(C)Cc1cccc(CSCCN)c1.CN=C=S>>CNC(=S)NCCSCc1cccc(CN(C)C)c1,,CC#N,,,,val
US20030105077A1,Cn1c(=O)[nH]c(=O)c2c1nc(Br)n2Cc1ccccc1C#N.NC1CCCCNC1>>Cn1c(=O)[nH]c(=O)c2c1nc(N1CCCCC(N)C1)n2Cc1ccccc1C#N,,CS(C)=O,ClCCl,CCN(CC)CC,O,val
US20150361059A1,CC(C)(C)OC(=O)N[C@@H](CO)C(=O)O.O=[N+]([O-])c1cccc(C(F)(F)F)c1F>>CC(C)(C)OC(=O)N[C@@H](COc1c([N+](=O)[O-])cccc1C(F)(F)F)C(=O)O,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20160130299A1,C=CCI.CC(C)(C)OC(=O)N1C(=O)CC[C@@H]1Cc1ccc([N+](=O)[O-])cc1>>C=CC[C@H]1C[C@H](Cc2ccc([N+](=O)[O-])cc2)N(C(=O)OC(C)(C)C)C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.Cc1ccc(O)c(C)n1>>COc1cc2nccc(Oc3ccc(C)nc3C)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,,,val
US20130005707A1,Brc1ncn(C2CCCCO2)n1.O=[N+]([O-])c1ccc(B(O)O)cc1>>O=[N+]([O-])c1ccc(-c2ncn(C3CCCCO3)n2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20150099888A1,COc1ccc(C(C)=O)cc1OC.COc1ccc(Nc2ncccc2C=O)cc1>>COc1ccc(Nc2ncccc2/C=C/C(=O)c2ccc(OC)c(OC)c2)cc1,,CO,,Cl,,val
US20150352225A1,CC(C)(C)[Si](C)(C)OCCNCCC(=O)OCc1ccccc1.CCOC(C)=O.[Br-]>>CC(C)(C)[Si](C)(C)OCCN(CCC(=O)OCc1ccccc1)C(=O)CBr,,CCOC(C)=O,,C1CCOC1,CCN(CC)CC,val
US20080249093A1,COC(=O)c1cc(Cl)c(OC(C)C)c(Cl)c1>>CC(C)Oc1c(Cl)cc(C(=O)O)cc1Cl,,CO,,[Na+].[OH-],,val
US20150018309A1,CC(C)(C)OC(=O)NC1CN(c2nc3ccccc3s2)C1.O=C(O)C(F)(F)F>>NC1CN(c2nc3ccccc3s2)C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20160200725A1,C=O.CC(C)(C)OC(=O)N1CCNCC1.CC(C)C=O>>CC(C)(C=O)CN1CCN(C(=O)OC(C)(C)C)CC1,,CC(=O)O,,,,val
US20090069320A1,N#CO[K].Nc1ccc(I)cc1C(=O)O>>O=c1[nH]c(=O)c2cc(I)ccc2[nH]1,,O,,CC(=O)O,[Na+].[OH-],val
US20160159820A1,COc1ccc(CNCc2c(F)ccnc2N)cc1.O=C(n1ccnc1)n1ccnc1>>COc1ccc(CN2Cc3c(F)ccnc3NC2=O)cc1,,CC#N,,CCOC(C)=O,,val
US20130261154A1,C=CCCCBr.O=c1[nH]c2cc(Cl)ccc2s1>>C=CCCCn1c(=O)sc2ccc(Cl)cc21,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US03956260,CC(C)(C)OC(=O)[C@@H]1CCCN1.O=C(O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)OCc1ccccc1,,C1CCOC1,CN(C)C=O,CC(C)COC(=O)Cl,CCN(CC)CC,val
US04990517,NCCCl.O=C1C=CC(=O)N1Cc1ccccc1>>O=C1CC(NCCCl)C(=O)N1Cc1ccccc1,,CCOC(C)=O,,CCN(CC)CC,Cl,val
US20060135770A1,COC(=O)c1cc(F)ccc1O.N>>NC(=O)c1cc(F)ccc1O,,CO,,,,val
US08247377B2,C=COC(=O)CCC.OCC(O)(CO)C(F)(F)F>>CCCC(=O)OC[C@@](O)(CO)C(F)(F)F,,COC(C)(C)C,,,,val
US20100209469A1,O=C(Br)CBr.O=Cc1ccccc1O>>O=Cc1ccccc1OC(=O)CBr,,ClCCl,,c1ccncc1,,val
US20080045556A1,CC(CO)Nc1nc(-c2ccc(Br)cc2)cs1.CCOC(C)=O>>CC1COC(=O)N1c1nc(-c2ccc(Br)cc2)cs1,,CCCCCC,,,,val
US20110118248A1,COC(=O)c1ncccc1N.O=S(=O)(Cl)c1ccc(Cl)c(C(F)(F)F)c1>>O=C(O)c1ncccc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1,,c1ccncc1,,C1CCOC1,[Li+].[OH-],val
US06489321B1,CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.OCCC1=CC=Nc2ccccc2S1>>CC(=O)Nc1ccc(S(=O)(=O)N2C=CC(CCO)Sc3ccccc32)cc1,,ClCCl,c1ccncc1,CO,,val
US20090099190A1,Cc1cc(F)c([N+](=O)[O-])cc1N1Cc2cnc(Cl)cc2N(C)C1=O>>Cc1cc(F)c(N)cc1N1Cc2cnc(Cl)cc2N(C)C1=O,[Zn],C1CCOC1,CO,[Cl-].[NH4+],,val
US20070105890A1,Cl.Cn1c(=O)c2c(nc(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)n2Cc2ccccc2Cl)c2c(C(=O)OC(C)(C)C)c(F)ccc21>>Cl.Cn1c(=O)c2c(nc(N3CCC[C@@H](N)C3)n2Cc2ccccc2Cl)c2c(C(=O)O)c(F)ccc21,,C1COCCO1,Cl,,,val
US04734410,CCOC(=O)CCCC(C#N)c1ccccc1>>CCOC(=O)CCCC(CN)c1ccccc1,[Ni],CCO,,,,val
US20110070192A1,C[Si](C)(C)CCOCn1c(=O)[nH]cc(I)c1=O.O=S(=O)(O[C@H]1CO[C@@H]2COC(c3ccccc3)O[C@H]2[C@H]1F)C(F)(F)F>>C[Si](C)(C)CCOCn1c(=O)c(I)cn([C@@H]2CO[C@@H]3COC(c4ccccc4)O[C@H]3[C@H]2F)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US04980352,CN(CCN)CCN.Nc1nc(N)c(C(=O)n2ccnc2)nc1Cl>>CN(CCN)CCNC(=O)c1nc(Cl)c(N)nc1N,,C1CCOC1,,,,val
US20030119811A1,COC(=O)c1cccc(C(=O)NCC2CCN(C(=O)OCc3ccc(C)cc3)CC2)c1>>Cc1ccc(COC(=O)N2CCC(CNC(=O)c3cccc(CO)c3)CC2)cc1,,CO,,[BH4-].[Na+],,val
US20110218192A1,O=C(C=Cc1cccc(Cl)c1)c1cc(Br)ccc1O>>O=C1CC(c2cccc(Cl)c2)Oc2ccc(Br)cc21,,CCO,O,[Na+].[OH-],,val
US20120302539A1,CC(C)(C)OC(=O)NC1CCN(S(=O)(=O)c2ccc(CN)cc2)CC1.O=C(Cl)Cc1ccccc1>>CC(C)(C)OC(=O)NC1CCN(S(=O)(=O)c2ccc(CNC(=O)Cc3ccccc3)cc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US03961055,CC(C)Oc1ccc2c(c1)N(CCCCl)c1cccc(S(C)(=O)=O)c1S2.OCCC1CCNCC1>>CC(C)Oc1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1cccc(S(C)(=O)=O)c1S2,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20090281152A1,BrCC1CC1.CCOC(=O)c1coc(-c2c[nH]c3ccc(Cl)cc23)n1>>CCOC(=O)c1coc(-c2cn(CC3CC3)c3ccc(Cl)cc23)n1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20040162285A1,Brc1ccc(Br)nc1.CC(C)CNn1c(=O)c(C2=NS(=O)(=O)c3cc(O)ccc3N2)c(O)c2ccccc21>>CC(C)CNn1c(=O)c(C2=NS(=O)(=O)c3cc(Oc4ccc(Br)cn4)ccc3N2)c(O)c2ccccc21,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06593489B1,COC(=O)[C@H]1C[C@@H]2NC(=O)O[C@@H]2[C@H]1Br>>COC(=O)C1=C[C@@H]2OC(=O)N[C@H]2C1,,ClCCl,,,,val
US20050113412A1,Cc1cc(C(=O)O)c2cc(F)ccc2n1.ClP(Cl)(Cl)(Cl)Cl>>Cc1cc(C(=O)Cl)c2cc(F)ccc2n1,,ClCCl,,,,val
US20110301167A1,CC(=O)Nc1ccc(S(=O)(=O)N=[N+]=[N-])cc1.CCOC(=O)CC(=O)c1cccc(Cl)c1F>>CCOC(=O)C(=[N+]=[N-])C(=O)c1cccc(Cl)c1F,,CC#N,,CCN(CC)CC,,val
US20140051679A1,CC1(C)OB(c2ccc(NC3CCOCC3)cc2)OC1(C)C.O=C(Nc1ccc2[nH]nc(I)c2c1)C(c1ccsc1)N1CCCC1>>O=C(Nc1ccc2[nH]nc(-c3ccc(NC4CCOCC4)cc3)c2c1)C(c1ccsc1)N1CCCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US05093345,CCOC(=O)C(Br)C(=O)OCC.Cc1cc([N+](=O)[O-])cc2c1S(=O)C=N2>>CCOC(=O)C(C(=O)OCC)N1CS(=O)c2c(C)cc([N+](=O)[O-])cc21,,CCO,,[Na],,val
US20110230476A1,CCC(=O)Nc1ccc(CCNC(=O)c2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)cc1>>C=CC(=O)Nc1ccc(CCNC(=O)c2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)cc1,[Pd],,,,,val
US20070249686A1,COc1ccc2c(ccn2-c2cc(Cl)ccc2[N+](=O)[O-])c1>>COc1ccc2c(ccn2-c2cc(Cl)ccc2N)c1,[Fe],CC(=O)O,,,,val
US20050004187A1,CC(C)(C)[Si](C)(C)Oc1ccc2c(Br)cn([Si](C)(C)C(C)(C)C)c2c1.CI>>Cc1cn([Si](C)(C)C(C)(C)C)c2cc(O[Si](C)(C)C(C)(C)C)ccc12,,C1CCOC1,,CCCCC,[Li]C(C)(C)C,val
US05364866,NCCN1CCC(c2noc3cc(F)ccc23)CC1.O=C1OC(=O)c2cc(Cl)c(Cl)cc21>>O=C1c2cc(Cl)c(Cl)cc2C(=O)N1CCN1CCC(c2noc3cc(F)ccc23)CC1,,ClCCl,,,,val
US20160222014A1,CC(C)(C)OC(=O)N(C1CC1)C1CCN(c2ccc([N+](=O)[O-])cc2)CC1>>CC(C)(C)OC(=O)N(C1CC1)C1CCN(c2ccc(N)cc2)CC1,[Pd],CO,,[H][H],,val
US20050250810A1,CN(Cc1cc2ccccc2n1C)C(=O)/C=C/c1ccc(N)nc1.COC(C)(CBr)OC>>CC(=O)CNc1ccc(/C=C/C(=O)N(C)Cc2cc3ccccc3n2C)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20140336106A1,C=C(C)C(=O)[C@H](CC1CC(F)(F)C1)NC(=O)OC(C)(C)C.[O-]Cl>>CC(C)(C)OC(=O)N[C@@H](CC1CC(F)(F)C1)C(=O)[C@@]1(C)CO1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US04529737,O=C(O)CC(O)Cc1ccc(-c2ccccc2)cc1.O=C1OC(Br)c2ccccc21>>O=C(CC(O)Cc1ccc(-c2ccccc2)cc1)OC1OC(=O)c2ccccc21,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20050191238A1,CC(C)(C)[Si](C)(C)OCCOCc1ccc(CO)cc1.CC(C)(C)n1ncc(O)c(Cl)c1=O>>CC(C)(C)n1ncc(OCc2ccc(COCCO[Si](C)(C)C(C)(C)C)cc2)c(Cl)c1=O,,C1CCOC1,O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160152608A1,Cc1cc(F)c([N+](=O)[O-])cc1N=C=S.[N-]=[N+]=NCC(=O)c1ccncc1>>Cc1cc(F)c([N+](=O)[O-])cc1Nc1ncc(-c2ccncc2)o1,,C1COCCO1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150225354A1,Cc1cc(OCc2ccccc2)cc(C2=NOC(CC(=O)OC(C)(C)C)(C(=O)OC(C)(C)C)C2)c1>>Cc1cc(O)cc(C2=NOC(CC(=O)OC(C)(C)C)(C(=O)OC(C)(C)C)C2)c1,[Pd],C1CCOC1,,[H][H],,val
US05780465,CC1(C)Cc2ccccc2C1c1cncnc1S(C)(=O)=O.CNS(C)(=O)=O>>CN(c1ncncc1C1c2ccccc2CC1(C)C)S(C)(=O)=O,,CN(C)C=O,,[H-].[Na+],,val
US20080161366A1,BrCCCCBr.O=S1(=O)Nc2ccccc2N1c1ccc(Cl)cc1>>O=S1(=O)N(CCCCBr)c2ccccc2N1c1ccc(Cl)cc1,,CCOCC,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100004235A1,CS(=O)(=O)OCC1CCCCCC1.N#Cc1n[nH]c2ncccc12>>N#Cc1nn(CC2CCCCCC2)c2ncccc12,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20060111375A1,CCCOC(=O)c1cc2ccccc2cc1Oc1ccnc2cc(OCCCl)c(OC)cc12.c1c[nH]cn1>>CCCOC(=O)c1cc2ccccc2cc1Oc1ccnc2cc(OCCn3ccnc3)c(OC)cc12,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100016319A1,Clc1ccnc(Cl)n1.O=C(NCc1ccccc1O)Nc1nnc(-c2ccco2)o1>>O=C(NCc1ccccc1Oc1ccnc(Cl)n1)Nc1nnc(-c2ccco2)o1,,CC(C)=O,,[Na+].[OH-],,val
US20150080549A1,CC(C)(C)OC(=O)N[C@H](CCCNC(=O)OCc1ccc(N=[N+]=[N-])cc1)C(=O)O[C@@H]1[C@H](COP(=O)(O)O[C@H]2C[C@H](n3ccc(N)nc3=O)O[C@@H]2COP(=O)(O)O)O[C@@H](n2cnc3c(N)ncnc32)[C@@H]1O>>[N-]=[N+]=Nc1ccc(COC(=O)NCCC[C@@H](N)C(=O)O[C@@H]2[C@H](COP(=O)(O)O[C@H]3C[C@H](n4ccc(N)nc4=O)O[C@@H]3COP(=O)(O)O)O[C@@H](n3cnc4c(N)ncnc43)[C@@H]2O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040082780A1,CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4N)ncn3)cccc2s1.O=CC1CCCCC1>>CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4NCC4CCCCC4)ncn3)cccc2s1,,ClCCCl,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05760032,CCOC(=O)C(Cc1cc(C(=O)c2ccccc2Cl)c(N)s1)C(=O)OCC>>Nc1sc(CCC(=O)O)cc1C(=O)c1ccccc1Cl,,CCO,,[K+].[OH-],,val
US20080200483A1,N[C@H]1C[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(Cl)nc32)[C@H](O)[C@@H]1O.O=C(Cl)C1CCC1>>O=C(N[C@H]1C[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(Cl)nc32)[C@H](O)[C@@H]1O)C1CCC1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20110118208A1,CC(C)(C)OC(=O)NN.O=C1CCN(C2CC2)CC1>>CC(C)(C)OC(=O)NN=C1CCN(C2CC2)CC1,,C1CCOC1,,,,val
US20080182876A1,CS(=O)(=O)Cl.OCCCc1ccc2ccccc2c1>>CS(=O)(=O)OCCCc1ccc2ccccc2c1,,ClCCl,,CCN(CC)CC,,val
US20050267095A1,Cn1c(S(=O)(=O)O)nc2ccccc21.NCC1(c2ccc(OCCCN3CCCC3)cc2)CCOCC1>>Cn1c(NCC2(c3ccc(OCCCN4CCCC4)cc3)CCOCC2)nc2ccccc21,,CC#N,,CCN(C(C)C)C(C)C,,val
US04589905,CCOC(=O)c1cnn(-c2ccccn2)c1C#N.CN>>CNC(=O)c1cnn(-c2ccccn2)c1C#N,,CN(C)C=O,,,,val
US20050234057A1,CCOC(=O)Cl.Nc1ccccc1N1CCC(NC(=O)C2(NC(=O)c3cc4ccccc4o3)CCCCC2)C(=O)C1>>CCOC(=O)Nc1ccccc1N1CCC(NC(=O)C2(NC(=O)c3cc4ccccc4o3)CCCCC2)C(O)C1,,ClCCl,,CCN(CC)CC,,val
US05387593,CI.OC1(c2ccc(F)cc2)CCC2(CC1)OCCO2>>COC1(c2ccc(F)cc2)CCC2(CC1)OCCO2,,C1CCOC1,,[H-].[Na+],,val
US20070249670A1,Cc1cccc(C)c1NC(=O)Nc1cc2ccccc2cc1C(=O)N(CC(=O)OCc1ccccc1)CC1CCCCC1>>Cc1cccc(C)c1NC(=O)Nc1cc2ccccc2cc1C(=O)N(CC(=O)O)CC1CCCCC1,[Pd],CCO,,,,val
US20140361252A1,COc1cccc(-c2cccnc2N)c1OC>>COc1cccc2c1oc1ncccc12,,C1CCOC1,CC(=O)O,CC(C)(C)ON=O,,val
US20110190489A1,CC(=O)O.COC(=O)c1ccc2c(c1)c(-c1cc3c4c(cnc3n1S(=O)(=O)c1ccc(C)cc1)cnn4C)cn2C.C[Mg]Cl>>Cc1ccc(S(=O)(=O)n2c(-c3cn(C)c4ccc(C(C)(C)O)cc34)cc3c4c(cnc32)cnn4C)cc1,,C1CCOC1,O,,,val
US20100113528A1,CC[C@@H](C)O.N#Cc1cc(C=O)ccc1F>>CC[C@@H](C)Oc1ccc(C=O)cc1C#N,,CN(C)C=O,,[H-].[Na+],,val
US20080242661A1,CNCc1ccc(F)cc1.Cn1nc(C2CCCC2)c2nc(Cl)[nH]c(=O)c21>>CN(Cc1ccc(F)cc1)c1nc2c(C3CCCC3)nn(C)c2c(=O)[nH]1,,CC(C)(C)O,,,,val
US20130210800A1,CSc1nccc(=O)[nH]1.O=C1CCC(=O)N1Cl>>CSc1ncc(Cl)c(=O)[nH]1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US06326386B1,CC(C)(C)OC(=O)N(CCOc1cc(Cl)cc(C(=O)N(CCCn2ncnn2)c2ccccc2F)c1)c1ccncc1>>O=C(c1cc(Cl)cc(OCCNc2ccncc2)c1)N(CCCn1ncnn1)c1ccccc1F,,ClCCl,O=C(O)C(F)(F)F,,,val
US20070244092A1,CC(C)(C)c1nc2cc(S(=O)(=O)Cl)ccc2n1CC1CCOCC1.O=C(NC1CC1)c1cn[nH]c1>>CC(C)(C)c1nc2cc(S(=O)(=O)n3cc(C(=O)NC4CC4)cn3)ccc2n1CC1CCOCC1,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20100227859A1,COC(=O)[C@@H](NS(=O)(=O)c1ccc2c(c1)oc1cc([N+](=O)[O-])c(Br)cc12)C(C)C>>COC(=O)[C@@H](NS(=O)(=O)c1ccc2c(c1)oc1cc(N)ccc12)C(C)C,[Pd],CO,,,,val
US20140228386A1,CCOC(=O)c1ccncc1Br.O=C1NCCN1c1cccc(C(F)(F)F)c1>>CCOC(=O)c1ccncc1N1CCN(c2cccc(C(F)(F)F)c2)C1=O,I[Cu]I,C1COCCO1,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US06011039,CCc1nnc(SCc2cc(N3CCOCC3)cc(NC(=O)OC(C)(C)C)n2)s1.Cc1cc(COS(C)(=O)=O)cc([N+](=O)[O-])c1>>CCc1nnc(SCc2cc(N3CCOCC3)cc(N(Cc3cc(C)cc([N+](=O)[O-])c3)C(=O)OC(C)(C)C)n2)s1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US04006144,CN(C)S(=O)(=O)c1ccc2c(c1)CC(Cl)c1ccccc1S2.O=C1OCCN1CCN1CCNCC1>>CN(C)S(=O)(=O)c1ccc2c(c1)CC(N1CCN(CCN3CCOC3=O)CC1)c1ccccc1S2,,ClC(Cl)Cl,,,,val
US20100240671A1,CO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)OC(C)(C)C.Cl>>CO[C@@H]1Cc2ccccc2[C@@H]1N.Cl,,C1COCCO1,CO,,,val
US20070099990A1,COc1cc(C(C)C)ccc1-c1coc2c(C)c(C)cc(C)c12>>COc1cc(C(C)C)ccc1C1COc2c(C)c(C)cc(C)c21,,CO,,,,val
US20130143863A1,Cc1noc(C)c1B(O)O.O=C1c2ccc(Cl)cc2CCN1c1cncc(CCl)c1>>Cc1noc(C)c1Cc1cncc(N2CCc3cc(Cl)ccc3C2=O)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20070142634A1,CCCN.O=C(Cl)OCc1ccccc1>>CCCNC(=O)OCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20070010511A1,C=CCOC1CN(C(=O)OC(C)(C)C)CCC1c1ccc(OCCCOCc2ccccc2OC)cc1.O=[Os](=O)(=O)=O>>COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCCO)cc1,O=[Os](=O)(=O)=O,C1CCOC1,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20050038080A1,CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1.O=S(=O)(O)c1ccccc1>>CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1.O=S(=O)(O)c1ccccc1,,CCO,,,,val
US20160137696A1,CCCCCCCCCCCCCCCCCC(=O)O.CN(C)C(OC(C)(C)C)OC(C)(C)C>>CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCC(=O)O,,Cc1ccccc1,,,,val
US20040171881A1,CCc1cccc(C2(NCC(O)C(N)Cc3cc(F)cc(F)c3)CC2)c1.O=C1CCC(=O)O1>>CCc1cccc(C2(NC[C@@H](O)[C@H](Cc3cc(F)cc(F)c3)NC(=O)CCC(=O)O)CC2)c1,,ClC(Cl)Cl,,,,val
US20050250822A1,O=C(CBr)c1ccc(Cl)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(C[P+](c1ccccc1)(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1.[Br-],,C1CCOC1,,,,val
US20050234057A1,O=C(NC1(C(=O)NC2CCNCC2O)CCCCC1)c1ccco1.O=[N+]([O-])c1cc(F)ccc1F>>O=C(NC1(C(=O)NC2CCN(c3ccc(F)cc3[N+](=O)[O-])CC2O)CCCCC1)c1ccco1,,CCO,,CCN(CC)CC,Cl,val
US20080009638A1,CC[C@@H](Br)C(N)=O.O=C1CCCN1>>CC[C@@H](C(N)=O)N1CCCC1=O,,CO,Cc1ccccc1,C[O-].[Na+],,val
US05254560,CC(C)(C)OC(=O)NCC1CCCNC1.NC(=O)c1ccnc(Cl)n1>>CC(C)(C)OC(=O)NCC1CCCN(c2nccc(C(N)=O)n2)C1,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20140148339A1,CCOC(=O)Cl.CON1CCN2C(=O)C(c3c(C)cc(C)cc3C)C(=O)N2CC1>>CCOC(=O)Oc1c(-c2c(C)cc(C)cc2C)c(=O)n2n1CCN(OC)CC2,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,,val
US20040058965A1,COC(=O)Cc1ccc(O)cc1.Cc1oc(-c2ccccc2)nc1COc1cccc(CCl)c1>>Cc1oc(-c2ccccc2)nc1COc1cccc(COc2ccc(CC(=O)O)cc2)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20020013325A1,CC(C)(C)OC(=O)[C@H](CCC(=O)O)NC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)[C@@H](N)CCC(=O)O,[Pd],CO,,CCOC(C)=O,,val
US20110009401A1,CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H](C2)[C@H]1CNCc1ccccc1>>CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H](C2)[C@H]1CN,[Pd],CCO,,,,val
US20090036422A1,CC(C)(C)OC(=O)Nc1cccc(Br)c1.O=C1COC1>>CC(C)(C)OC(=O)Nc1cccc(C2(O)COC2)c1,,C1CCOC1,,[Li]CCCC,,val
US20140275288A1,CCOCC.O=C(Cl)C(=O)Cl.OCCc1ccccc1.c1ccncc1>>O=C(OCCc1ccccc1)C(=O)OCCc1ccccc1,,c1ccncc1,,,,val
US20070254363A1,Cc1ccc(-c2ncco2)cc1-c1ccc(NC(=O)C(CC(C)C)NC(=O)OC(C)(C)C)cc1>>Cc1ccc(-c2ncco2)cc1-c1ccc(NC(=O)C(N)CC(C)C)cc1,,ClCCl,,CO,O=C(O)C(F)(F)F,val
US20140296225A1,N#Cc1ccc2c(c1)CCC(N1CCNCC1=O)C2.O=CCc1ccc2c(=O)occc2c1>>N#Cc1ccc2c(c1)CCC(N1CCN(CCc3ccc4c(=O)occc4c3)CC1=O)C2,,CC(Cl)Cl,O,CCN(CC)CC,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20030008175A1,Cc1cccc(I)c1.c1ccc2c(c1)[nH]c1ccccc12>>Cc1cccc(-n2c3ccccc3c3ccccc32)c1,,Clc1ccccc1Cl,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20150368265A1,CNC(=O)c1c(-c2ccc(C#N)cc2)oc2cc(N)c(Br)cc12.CS(=O)(=O)Cl>>CNC(=O)c1c(-c2ccc(C#N)cc2)oc2cc(NS(C)(=O)=O)c(Br)cc12,,ClCCl,c1ccncc1,,,val
US20040063581A1,CC(C)CO.O=c1[nH]c(OCc2ccccc2)no1>>CC(C)Cn1c(OCc2ccccc2)noc1=O,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04139621,CC(=O)OC(C)=O.Clc1cc(N2CCNCC2)cc(Cl)c1Cl>>CC(=O)N1CCN(c2cc(Cl)c(Cl)c(Cl)c2)CC1,,CCO,,,,val
US20150183801A1,Cc1ncncc1B1OC(C)(C)C(C)(C)O1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1ccc(N2C[C@H](O)[C@@H](O)C2)c(Br)c1>>Cc1ncncc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)ccc1N1C[C@H](O)[C@@H](O)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04576958,BrBr.CSc1ccc(C(=O)Cc2ccccc2)cc1>>CSc1ccc(C(=O)C(Br)c2ccccc2)cc1,,CCOCC,ClCCl,,,val
US20120108583A1,CC1(C)Cc2c(c(C(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc3nc(Nc4c(Cl)cncc4Cl)[nH]c23)O1.CS(=O)(=O)O>>CC1(C)Cc2c(c(C(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc3nc(Nc4c(Cl)cncc4Cl)[nH]c23)O1.CS(=O)(=O)O,,CC(C)=O,,,,val
US05418241,CC(C)I.CCOC(=O)c1cccc([N+](=O)[O-])c1NC(=O)OC(C)(C)C>>CCOC(=O)c1cccc([N+](=O)[O-])c1NC(C)C,,CN(C)C=O,,[H-].[Na+],,val
US05032594,CCCn1c(=O)c2c(nn3cc[nH]c23)n(Cc2ccccc2)c1=O>>CCCn1c(=O)[nH]c2nn3cc[nH]c3c2c1=O,,CO,,BrB(Br)Br,,val
US20070185168A1,CCOC(=O)N1CC[C@@H](c2cccs2)[C@H](O)C1>>O[C@@H]1CNCC[C@H]1c1cccs1,,CC(C)O,,[K+].[OH-],,val
US20130261081A1,Clc1ccc(N2CCN(Cc3ccccc3)[C@H]3CCCC[C@@H]32)cc1>>Clc1ccc(N2CCN[C@H]3CCCC[C@@H]32)cc1,,ClCCl,,CC(Cl)OC(=O)Cl,,val
US06124283,CCCCOc1ccc(C(=O)Cl)cc1.CN1CCN(c2cccc3c2C[C@H](N)CC3)CC1>>CCCCOc1ccc(C(=O)N[C@@H]2CCc3cccc(N4CCN(C)CC4)c3C2)cc1,,ClCCl,,CCN(CC)CC,,val
US20100240669A1,CC(C)(C)OC(=O)NC1(C(=O)NCc2ccc(Nc3ccc(Cl)cc3C(F)(F)F)cn2)CC1.O=C(O)C(F)(F)F>>NC1(C(=O)NCc2ccc(Nc3ccc(Cl)cc3C(F)(F)F)cn2)CC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20150232474A1,CCOC(=O)c1cnc(SC)nc1NCc1ccc(OC)c(F)c1.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)c1cnc(S(C)=O)nc1NCc1ccc(OC)c(F)c1,,ClCCl,,,,val
US04837225,CCOC(=O)c1ccc(NC(=O)NCCn2c(C)ccc2C)cc1>>Cc1ccc(C)n1CCNC(=O)Nc1ccc(C(=O)O)cc1,,CO,,Cl,[Na+].[OH-],val
US20080032988A1,CN(C)C=O.Cc1ccc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NC(C)(C)C)s1>>Cc1ccc(C(=O)NC2CC2)cc1-c1cc(C=O)c(C(=O)NC(C)(C)C)s1,,CCOC(C)=O,,C1CCOC1,[Li]CCCC,val
US03950522,C=CCN.NC(=S)Cc1ccccn1>>C=CCNC(=S)Cc1ccccn1,,CCO,,O,,val
US05747501,BrBr.O=C(Nc1ccccc1)C(F)(F)F>>O=C(Nc1ccccc1Br)C(F)(F)F,,CO,,O=C([O-])O.[Na+],,val
US20060252807A1,CC(=O)CC(C)=O.CCN(CC)CC.CCO>>CC(=O)c1c(-c2ccccc2)noc1C,,CCO,,,,val
US06100258,C=C(C)COc1ccc(Cl)cc1CNCC.NC(=O)c1ccc(Cl)nn1>>C=C(C)COc1ccc(Cl)cc1CN(CC)c1ccc(C(N)=O)nn1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20030109556A1,CNC(=O)C(Cc1ccc2ccccc2c1)N1CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])C(CCO[Si](C)(C)C(C)(C)C)C1=O>>CNC(=O)C(Cc1ccc2ccccc2c1)N1CCNC(CCO[Si](C)(C)C(C)(C)C)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150073019A1,COC(OC)N(C)C.O=c1cc(-c2cccc(Cl)c2)[nH]n1-c1nc2ccccc2s1>>CN(C)C=C1C(=O)N(c2nc3ccccc3s2)N=C1c1cccc(Cl)c1,,C1CCOC1,,,,val
US20090247517A1,CCOC(=O)c1nnn(-c2ccccc2)c1N.ClC(=Nc1ccc(Cl)cc1)c1ccc(Br)cc1>>O=c1c2nnn(-c3ccccc3)c2nc(-c2ccc(Br)cc2)n1-c1ccc(Cl)cc1,Cl[Ti](Cl)(Cl)Cl,CC(Cl)Cl,,,,val
US20160009704A1,COCCNC(=O)c1nnc(CCC#Cc2ccc(NC(=O)Cc3cccc(OC(F)(F)F)c3)nn2)s1>>COCCNC(=O)c1nnc(CCCCc2ccc(NC(=O)Cc3cccc(OC(F)(F)F)c3)nn2)s1,[Pd],C1CCOC1,,,,val
US04859692,COC(=O)c1ccc(Cc2csc3ccc([N+](=O)[O-])cc23)c(OC)c1>>COC(=O)c1ccc(Cc2csc3ccc(N)cc23)c(OC)c1,,CCO,,O=C([O-])O.[Na+],,val
US20100120806A1,CC(C)(C)O.O=C(Cl)c1cc(Cl)ccn1>>CC(C)(C)OC(=O)c1cc(Cl)ccn1,CN(C)c1ccncc1,ClCCl,c1ccncc1,,,val
US20150126498A1,Cc1cc(NS(=O)(=O)c2ccccc2N)cnc1C.O=C(n1ccnc1)n1ccnc1>>Cc1cc(N2C(=O)Nc3ccccc3S2(=O)=O)cnc1C,,ClCCCl,,,,val
US20160221945A1,COC(=O)c1cc(-c2cnc(C(F)(F)F)nc2)ncc1C>>Cc1cnc(-c2cnc(C(F)(F)F)nc2)cc1CO,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20120053200A1,Cc1ccc(C2CCCN2)cc1.O=C(O)c1cccc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)c1>>Cc1ccc(C2CCCN2C(=O)c2cccc(C(=O)N[C@@H](Cc3ccccc3)[C@H](O)CNCc3cccc(C(F)(F)F)c3)c2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20040006056A1,CC(=O)Nc1ccc(CC(=O)O)cc1.CC(=O)OC(C)=O.CCN(CC)CC.O=C=O>>CC(=O)Nc1ccc(C2C(=O)c3ccccc3C2=O)cc1,,CCN(CC)CC,,,,val
US20130345215A1,Cn1ncc2c(O)nc(Cl)nc21.OCC(CCl)Oc1cc(F)c(N2CCNCC2)c(F)c1>>Cn1ncc2c(O)nc(N3CCN(c4c(F)cc(OC(CO)CCl)cc4F)CC3)nc21,,CCO,,CCN(C(C)C)C(C)C,,val
US04209516,CCN.O=C(Cl)c1nc(CCl)n(-c2ccc(Cl)cc2C(=O)c2ccccc2Cl)n1>>CCNC(=O)c1nc(CCl)n(-c2ccc(Cl)cc2C(=O)c2ccccc2Cl)n1,,C1COCCO1,,,,val
US05929097,COC(=O)c1cc(C)cc(C)c1N(Cc1cccc(OC)c1)S(=O)(=O)c1ccc(OC)cc1>>COc1ccc(S(=O)(=O)N(Cc2cccc(OC)c2)c2c(C)cc(C)cc2C(=O)O)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US05328920,CCOC(=O)c1[nH]c2ccccc2c1N.Clc1ccncc1>>CCOC(=O)c1[nH]c2ccccc2c1Nc1ccncc1,,CN1CCCC1=O,,Cl,,val
US20090175794A1,NCCc1ccc(S(N)(=O)=O)cc1.O=C1CCC(=O)O1>>NS(=O)(=O)c1ccc(CCNC(=O)CCC(=O)O)cc1,,C1COCCO1,,,,val
US20090264445A1,COC(=O)[C@H](CC1CCCCC1)N1CC(Oc2cccc(F)c2F)=CC1=O>>O=C(O)[C@H](CC1CCCCC1)N1CC(Oc2cccc(F)c2F)=CC1=O,,C1CCOC1,O,[Li+].[OH-],,val
US20060189617A1,CC(C)(C)c1ccc(-c2nc3c(N4CCNCC4)ccnc3[nH]2)cc1.O=Cc1c[nH]c(=O)[nH]c1=O>>CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5c[nH]c(=O)[nH]c5=O)CC4)ccnc3[nH]2)cc1,,CN1CCCC1=O,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20060247320A1,BrCc1ccccc1.COC(=O)c1cc2c(nc1S)CCC(C(C)(C)C)C2>>COC(=O)c1cc2c(nc1SCc1ccccc1)CCC(C(C)(C)C)C2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060223872A1,CCOC(=O)CN(Cc1ccc([N+](=O)[O-])c(C)c1)C(=O)Nc1ccc(C(F)(F)F)cc1>>Cc1cc(CN2CC(=O)N(c3ccc(C(F)(F)F)cc3)C2=O)ccc1[N+](=O)[O-],,O,,CC(=O)O,Cl,val
US20040116466A1,Nc1cc2nc(-c3ccc([N+](=O)[O-])cc3)[nH]c2cn1.O=C(Cl)C1CCCCCC1>>O=C(Nc1cc2nc(-c3ccc([N+](=O)[O-])cc3)[nH]c2cn1)C1CCCCCC1,,c1ccncc1,,,,val
US20130143863A1,COC(=O)Cc1cncc(Br)c1.O=C1NCCc2cc(Cl)ccc21>>O=C(O)Cc1cncc(N2CCc3cc(Cl)ccc3C2=O)c1,[Cu]I,C1COCCO1,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05707989,COC(=O)[C@@H]1CC[C@@H](CNc2ncc3ncnc(Nc4ccc(F)c(Cl)c4)c3n2)CC1>>O=C(O)[C@@H]1CC[C@@H](CNc2ncc3ncnc(Nc4ccc(F)c(Cl)c4)c3n2)CC1,,C1CCOC1,CO,[Na+].[OH-],,val
US06252042B1,CCOC(=O)OCC.NCCN>>CCOC(=O)NCCN,,CCO,,,,val
US20050165063A1,CCCN(CCC)CCCCc1nc2ccc(CO)cc2n1CCC.O=C1NC(=O)c2ccccc21>>CCCN(CCC)CCCCc1nc2ccc(CN3C(=O)c4ccccc4C3=O)cc2n1CCC,,Cc1ccccc1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060264424A1,CCOC(=O)C(F)(F)F.O=C(c1cccc(N(CCC(F)(F)F)S(=O)(=O)c2ccccc2)c1)C(F)(F)F.O=S(=O)(c1ccccc1)N(CCC(F)(F)F)c1cccc(Br)c1>>CS(=O)(=O)c1ccc(C#CC(O)(c2cccc(N(CCC(F)(F)F)S(=O)(=O)c3ccccc3)c2)C(F)(F)F)cc1,,C1CCOC1,,[Li]CCCC,,val
US20050049245A1,CNCC(O)c1cc2ccccc2o1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)sc21>>CN(Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2s1)CC(O)c1cc2ccccc2o1,,O,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20050239841A1,COc1ccc([C@@]23CC[C@@H](N)C[C@@H]2N(C)CC3)cc1OC.N#CNC(=Nc1cc(Cl)cc(Cl)c1)Oc1ccccc1>>COc1ccc([C@@]23CC[C@@H](N=C(NC#N)Nc4cc(Cl)cc(Cl)c4)C[C@@H]2N(C)CC3)cc1OC,,CN(C)C=O,,ClCCl,,val
US20110015175A1,Cc1cn(-c2ccc([N+](=O)[O-])cc2F)c(C)n1>>Cc1cn(-c2ccc(N)cc2F)c(C)n1,[Pd],CO,,,,val
US20130197230A1,COc1cc2c(Oc3ccc([N+](=O)[O-])cc3F)ccnc2cc1OCCCN1CCOCC1>>COc1cc2c(Oc3ccc(N)cc3F)ccnc2cc1OCCCN1CCOCC1,[Pd],CCO,O,[H][H],,val
US04781857,CCCCCCBr.CCCCCCCc1ccc(-c2ccc(O)c(F)c2)nc1>>CCCCCCCc1ccc(-c2ccc(OCCCCCC)c(F)c2)nc1,,Cc1ccccc1,O,CCO,[K+].[OH-],val
US06528653B2,CC(C)(C)OC(=O)c1cc2c(s1)NC(=O)/C2=C\c1ccc[nH]1>>O=C1Nc2sc(C(=O)O)cc2/C1=C/c1ccc[nH]1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05294603,CCC(=O)OC(=O)CC.O=C(O)[C@@H]1CCCN1>>CCC(=O)N1CCC[C@H]1C(=O)O,,c1ccncc1,,,,val
US05854410,COC(=O)c1cc(CN=[N+]=[N-])cc(CN=[N+]=[N-])c1>>COC(=O)c1cc(CN)cc(CN)c1,[Pd],CO,,,,val
US20080293776A1,CC(=O)Cl.C[Si](C)(C)CCN1C(=O)CN(c2ccc(Cc3ccccc3N)cc2OCc2ccccc2)S1(=O)=O>>CC(=O)Nc1ccccc1Cc1ccc(N2CC(=O)N(CC[Si](C)(C)C)S2(=O)=O)c(OCc2ccccc2)c1,,CCOC(C)=O,c1ccncc1,,,val
US20060194859A1,COC(=O)[C@@H]1CCC[C@H]1C(=O)c1ccc(-c2ccc(Nc3nc4cc(F)ccc4s3)cc2)cc1>>O=C(c1ccc(-c2ccc(Nc3nc4cc(F)ccc4s3)cc2)cc1)[C@@H]1CCC[C@H]1C(=O)O,,C1CCOC1,,CO,[Na+].[OH-],val
US05491167,C[C@H]1C=CC2=C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](OC(=O)C(C)(C)Oc3ccc([N+](=O)[O-])cc3)[C@@H]2[C@H]1CC[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O1>>C[C@H]1C=CC2=C[C@@H](O)C[C@H](OC(=O)C(C)(C)Oc3ccc([N+](=O)[O-])cc3)[C@@H]2[C@H]1CC[C@@H]1C[C@@H](O)CC(=O)O1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05612377,CCC(CC)NOCc1ccccc1.CN(C(=O)Cl)c1ccccc1>>CCC(CC)N(OCc1ccccc1)C(=O)N(C)c1ccccc1,CN(C)c1ccncc1,CCN(CC)CC,,C1CCOC1,,val
US20130102576A1,CS(=O)(=O)Nc1ccc2c(c1)CCN2CC(=O)OCc1ccccc1>>CS(=O)(=O)Nc1ccc2c(c1)CCN2CC(=O)O,[Pd],CO,O,,,val
US20120316161A1,COC(=O)C(CCCC(F)(F)F)c1c(C)nc2cc(C(C)(C)C)nn2c1Cl.COCCOC.Cc1ccc(B(O)O)cc1>>CCC(C)C(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc(C)cc1,,COCCOC,O,CCN(C(C)C)C(C)C,,val
US05541286,BrCc1ccccc1.C=CCc1ccccc1O>>C=CCc1ccccc1OCc1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US04263291,CON=C(C(=O)OC)c1cnsn1>>CON=C(C(=O)O)c1cnsn1,,CO,,[Na+].[OH-],,val
US20150313234A1,O=S(c1ccc(O)cc1)C(F)(F)F.O=[N+]([O-])O>>O=[N+]([O-])c1cc(S(=O)C(F)(F)F)ccc1O,,CC(=O)O,,O=S(=O)(O)O,,val
US20030170858A1,CCN.CCOC(=O)c1[nH]nc(-c2cnc(-c3ccccc3)s2)c1Cl>>CCNC(=O)c1[nH]nc(-c2cnc(-c3ccccc3)s2)c1Cl,O,C1CCOC1,,,,val
US20130150343A1,C[C@H]1CCCCN1C(=O)Cl.NNc1ccc(F)cn1>>C[C@H]1CCCCN1C(=O)NNc1ccc(F)cn1,,CO,ClCCl,CCN(C(C)C)C(C)C,O,val
US20100249123A1,CN(C)C(OC(C)(C)C)N(C)C.Cc1ccc([N+](=O)[O-])cc1Cl.NOS(=O)(=O)O>>N#CCc1ccc([N+](=O)[O-])cc1Cl,,O,,,,val
US20040009983A1,BrBr.CN(C)c1ccc(C#N)cc1>>CN(C)c1ccc(C#N)cc1Br,,ClC(Cl)Cl,ClCCl,c1ccncc1,,val
US20060128685A1,ClCCl.FC1(F)CCN(Cc2ccccc2)CC1>>Cl.FC1(F)CCNCC1,,ClCCl,,CC(Cl)OC(=O)Cl,,val
US20070099871A1,CC(=O)NCCc1cccc(O)c1.CC(C)(O)c1ccc([N+](=O)[O-])s1>>CC(=O)NCCc1cccc(OC(C)(C)c2ccc([N+](=O)[O-])s2)c1,,c1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20020091147A1,CCOC(=O)N1CCNCC1.Nc1ccc(CCC(=O)c2ccc(F)cc2)cc1>>CCOC(=O)N1CCN(c2ccc(C(=O)CCc3ccc(N)cc3)cc2)CC1,,CCOC(C)=O,CS(C)=O,CC(C)NC(C)C,,val
US20090029965A1,CCCCCCBr.Cn1ncc2c1Nc1cc(Cl)ccc1N(C(=O)c1ccc(OCCCN3CCNCC3)cc1F)C2>>CCCCCCN1CCN(CCCOc2ccc(C(=O)N3Cc4cnn(C)c4Nc4cc(Cl)ccc43)c(F)c2)CC1,,CCN(CC)CC,CN(C)C=O,Cl,Cl,val
US20020055507A1,CC(=O)O.O=C1Cc2ccccc2N1>>CC(=O)N1C(=O)Cc2ccccc21,,CC(=O)O,O,CC(=O)OC(C)=O,,val
US05616594,Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(CO)c(Cl)c1.FC(F)(F)c1cnc(Cl)c(Cl)c1>>Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(COc2ncc(C(F)(F)F)cc2Cl)c(Cl)c1,,COCCOC,,O,[H-].[Na+],val
US20100035279A1,Cc1ccccc1.O=C(CC(=O)Oc1c(Cl)cc(Cl)cc1Cl)Oc1c(Cl)cc(Cl)cc1Cl>>O=c1ccc2ccccc2o1,,Cc1ccccc1,,,,val
US03931162,C1CCNCC1.C=O.CC(C)C(C(N)=S)c1ccccn1>>CC(C)C(C(=S)NCN1CCCCC1)c1ccccn1,,CO,,,,val
US04284631,CCOC(=O)C(=NOCc1ccc(Cl)cc1Cl)C(C)=O.O=S(=O)(Cl)Cl>>CCOC(=O)C(=NOCc1ccc(Cl)cc1Cl)C(=O)CCl,,CC(=O)O,,,,val
US20080221195A1,CC(C)Oc1ccc(C#Cc2ccc(C(=O)O)cc2)cc1C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12.Nc1cccnc1>>CC(C)Oc1ccc(C#Cc2cccc(C(=O)Nc3cccnc3)c2)cc1C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12,,CC(=O)N(C)C,O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150218165A1,Brc1ccnc2[nH]ccc12.CNc1ccccc1B1OC(C)(C)C(C)(C)O1>>CNc1ccccc1-c1ccnc2[nH]ccc12,,O,,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20030181494A1,CO.Cc1cc(C)cc(C=C(C(=O)On2nnc3ccccc32)c2ccc(Oc3ccc(CC4SC(=O)NC4=O)cc3)cc2)c1>>COC(=O)C(=Cc1cc(C)cc(C)c1)c1ccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)cc1,,CO,Cl,C[O-].[Na+],,val
US20050256099A1,Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc2oc(=O)[nH]c12.NS(=O)(=O)N1CCC(C2CCNCC2)CC1>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(C3CCN(S(N)(=O)=O)CC3)CC2)cc2oc(=O)[nH]c12,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20070167488A1,Cc1cc(C)c(C=O)[nH]1.O=C1CCC(=O)N1Br>>Cc1[nH]c(C=O)c(C)c1Br,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20060235030A1,CCCNC(=O)c1ccc(C)c(-c2nc(S(C)(=O)=O)nc3c2CNC(=O)N3c2c(F)cccc2F)c1.NCCC(=O)O>>CCCNC(=O)c1ccc(C)c(-c2nc(NCCC(=O)O)nc3c2CNC(=O)N3c2c(F)cccc2F)c1,,CN(C)C=O,,CCN(CC)CC,,val
US20100152160A1,C=C/C(=C\C=C(/C)F)CC(C#N)(CC)CCN(C)C(=O)C1CN(C(=O)OC(C)(C)C)c2cc(Cl)c(N(C)c3nn[nH]n3)cc2O1>>C=C/C(=C\C=C(/C)F)CC(C#N)(CC)CCN(C)C(=O)C1CNc2cc(Cl)c(N(C)c3nn[nH]n3)cc2O1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160009726A1,C=CB1OC(C)(C)C(C)(C)O1.CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccncc2NC(=O)c2ccc3scc(Br)c3n2)C1>>C=Cc1csc2ccc(C(=O)Nc3cnccc3N3CCC[C@H](NC(=O)OC(C)(C)C)C3)nc12,,CCOC(C)=O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US05712299,Cc1ncsc1[Si](C)(C)C.O=Cc1ccc(Cl)cc1>>Cc1ncsc1C(O)c1ccc(Cl)cc1,,C1CCOC1,,[Cs+].[F-],,val
US20110288111A1,C1CCC2(CC1)CCNCC2.S=C=NC(c1ccccc1)(c1ccccc1)c1ccccc1>>NC(=S)N1CCC2(CCCCC2)CC1,,C1CCOC1,,ClCCl,O=C(O)C(F)(F)F,val
US20160264518A1,Brc1nc2ccccc2[nH]1.COCCBr>>COCCn1c(Br)nc2ccccc21,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20100305067A1,Brc1cnc2ccccn12.CCCC[Sn](Cl)(CCCC)CCCC>>CCCC[Sn](CCCC)(CCCC)c1cnc2ccccn12,,C1CCOC1,,[Li]CCCC,,val
US20090069287A1,CC(C)c1cccc(C2(N=[N+]=[N-])CN(C(c3ccccc3)c3ccccc3)C2)c1>>CC(C)c1cccc(C2(N)CN(C(c3ccccc3)c3ccccc3)C2)c1,[Pd],CCO,,[H][H],,val
US04098889,CS(=O)(=O)Nc1ccc(NS(C)(=O)=O)c(S)c1.ClCCN1CCCCC1>>CS(=O)(=O)Nc1ccc(NS(C)(=O)=O)c(SCCN2CCCCC2)c1.Cl,,CCO,,,,val
US20040087798A1,NCc1cccnc1.O=[N+]([O-])c1ccc(Cl)nc1>>O=[N+]([O-])c1ccc(NCc2cccnc2)nc1,,C1CCOC1,,O,,val
US20050038101A1,CC(C)(C)OC(=O)Nc1ccc(NC(=O)c2cc3cc(N)ccc3n2Cc2ccccc2F)cc1.O=C(O)CC1CCCO1>>CC(C)(C)OC(=O)Nc1ccc(NC(=O)c2cc3cc(NC(=O)CC4CCCO4)ccc3n2Cc2ccccc2F)cc1,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US04404018,CC(Oc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-])C(=O)Cl.NCC1CCCO1>>CC(Oc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-])C(=O)NCC1CCCO1,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US20060258725A1,COC(=O)c1ccc(C(=O)Nc2ccc(OCc3c(-c4c(Cl)cccc4Cl)noc3C(C)C)cc2Cl)cc1>>CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(NC(=O)c2ccc(C(=O)O)cc2)c(Cl)c1,,C1CCOC1,,[Li+].[OH-],,val
US20090023747A1,Brc1ccc(Br)cc1.CC(C)CC1CO[C@@H](C(F)(F)F)N1>>CC(C)C[C@@H](CO)NC(c1ccc(Br)cc1)C(F)(F)F,,C1CCOC1,,[Li]CCCC,,val
US20070232583A1,CN1CCNCC1.O=S(=O)(Cl)c1cccc(-c2cc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)ccn2)c1>>CN1CCN(S(=O)(=O)c2cccc(-c3cc(-c4nc(-c5ccc(C(F)(F)F)cc5)cc(C(F)(F)F)n4)ccn3)c2)CC1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20140221335A1,O=C1C=C(Nc2cccc(C(F)(F)F)c2)CC1.O=C=NC(Cl)c1ccc(Cl)nc1>>O=C1CCC2=C1C(c1ccc(Cl)nc1)NC(=O)N2c1cccc(C(F)(F)F)c1,,ClCCl,,,,val
US20150141413A1,CC1(C)C(=O)N[C@](C)(c2cc(Br)ccc2F)CS1(=O)=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC1(C)C(=S)N[C@](C)(c2cc(Br)ccc2F)CS1(=O)=O,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20150329562A1,C[C@H]1CNC(=O)[C@@H]([C@@H](O)C(=O)OC(C)(C)C)O1.FC(F)(F)c1cc(-n2ccc(I)n2)cnn1>>C[C@H]1CN(c2ccn(-c3cnnc(C(F)(F)F)c3)n2)C(=O)[C@@H]([C@@H](O)C(=O)OC(C)(C)C)O1,[Cu]I,C1COCCO1,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20150064624A1,CCn1c2ccccc2c2ccccc21.Cc1cc(C)c(C(=O)Cl)c(C)c1.O=C(Cl)c1ccccc1F>>CCn1c2ccc(C(=O)c3ccccc3F)cc2c2cc(C(=O)c3c(C)cc(C)cc3C)ccc21,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080242683A1,O=C(OCc1ccccc1)N1CCN(C2CCN(c3nc(NCC(c4ccccc4)c4ccccc4)c4ncn([C@@H]5O[C@H](CO)[C@@H](O)[C@H]5O)c4n3)C2)CC1>>OC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(N4CCC(N5CCNCC5)C4)nc32)[C@H](O)[C@@H]1O,[Pd],CCO,,O=C(O)C(F)(F)F,,val
US20110124665A1,CC(C)(C)OC(=O)CBr.O[C@H]1C=C[C@@H](O)C1>>CC(C)(C)OC(=O)COC1C=CC(O)C1,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20150119393A1,CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@H](Oc3nc4cc(Cl)c(-c5ccc([C@@H]6CC[C@H](O)CC6)cc5)nc4n3COCC[Si](C)(C)C)CO[C@H]12.O=C(Cl)N1CCOCC1>>CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@H](Oc3nc4cc(Cl)c(-c5ccc([C@H]6CC[C@@H](OC(=O)N7CCOCC7)CC6)cc5)nc4n3COCC[Si](C)(C)C)CO[C@H]12,,c1ccncc1,,,,val
US20140275058A1,CO.O=C(O)c1ncc(Cl)nc1Cl>>COC(=O)c1ncc(Cl)nc1Cl,,CCOCC,CO,C[Si](C)(C)C=[N+]=[N-],,val
US20060019985A1,CC(C)(C)OC(=O)N1CCC(O)CC1.CS(=O)(=O)OCC1CCN(Cc2ccccc2)C1>>CC(C)(C)OC(=O)N1CCC(OCC2CCN(Cc3ccccc3)C2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US05385925,CCCc1nc2ccc(-c3nc4cccnc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCc1nc2ccc(-c3nc4cccnc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05223498,CI.Cc1ccc(N2CCOCC2)c(NC(N)=S)c1>>CSC(=N)Nc1cc(C)ccc1N1CCOCC1.I,,CO,,,,val
US20150315198A1,CC(=O)c1ccc(Cn2cccn2)cc1>>CC(O)c1ccc(Cn2cccn2)cc1,,C1CCOC1,CCOC(C)=O,CO,[BH4-].[Na+],val
US20060111360A1,CN1CCN(CCCN(C(=O)Nc2ccc(F)c(Cl)c2)C2CCc3ccc(N)cc3C2)CC1.CS(=O)(=O)Cl>>CN1CCN(CCCN(C(=O)Nc2ccc(F)c(Cl)c2)C2CCc3ccc(NS(C)(=O)=O)cc3C2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040072827A1,CCOC(=O)CN(CCCn1c(-c2ccc(F)cc2)csc1=Nc1ccc(Cl)cc1OC)C(=O)OC(C)(C)C>>COc1cc(Cl)ccc1N=c1scc(-c2ccc(F)cc2)n1CCCN(CCO)C(=O)OC(C)(C)C,,C1CCOC1,,O,[BH4-].[Li+],val
US20110053949A1,Nc1cnoc1.O=C(Cl)Oc1ccccc1>>O=C(Nc1cnoc1)Oc1ccccc1,,C1CCOC1,CCOC(C)=O,c1ccncc1,,val
US20060004017A1,COc1cc2c(Cl)ncnc2cc1OCCCN1CCCCC1.Oc1cc2cc[nH]c2cc1C(F)(F)F>>COc1cc2c(Oc3cc4cc[nH]c4cc3C(F)(F)F)ncnc2cc1OCCCN1CCCCC1,,ClCCl,,CC(=O)N(C)C,O=C([O-])[O-].[K+].[K+],val
US20150368267A1,CC(C)(C)OC(=O)c1ccc(Nc2nc(NCc3ccc(O)cc3)nc(OCC(F)(F)F)n2)cc1.C[C@H](CO)CBr>>C[C@@H](CBr)COc1ccc(CNc2nc(Nc3ccc(C(=O)OC(C)(C)C)cc3)nc(OCC(F)(F)F)n2)cc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100279931A1,CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCC(=O)O.[N-]=[N+]=NP(=O)(Oc1ccccc1)Oc1ccccc1>>CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCN,,CC#N,,,,val
US20090118284A1,O=C1OCCO1.O=[N+]([O-])c1ccc2c(c1)c(-c1ccc(F)c(O)c1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1>>O=[N+]([O-])c1ccc2c(c1)c(-c1ccc(F)c(OCCO)c1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20140163026A1,COC(=O)c1cc([N+](=O)[O-])c(Br)cc1Cl>>COC(=O)c1cc(N)c(Br)cc1Cl,,CO,,[BH4-].[Na+],,val
US20050143443A1,CCOC(=O)c1cc(CCc2ccc(Cl)cc2)c(C)[nH]1>>Cc1[nH]c(C(=O)O)cc1CCc1ccc(Cl)cc1,,C1COCCO1,,[Na+].[OH-],,val
US04402803,CS(=O)(=O)OC1=C(C(=O)O)N2C(=O)C(NC(=O)Cc3cccs3)[C@H]2SC1>>O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)O)=CCS[C@H]12,,CCO,,,,val
US20040209921A1,O=C1c2ccccc2C(=O)N1CCCCNC1CCCc2cccnc21.O=C1c2ccccc2C(=O)N1c1cccc(CBr)n1>>O=C1c2ccccc2C(=O)N1CCCCN(Cc1cccc(N2C(=O)c3ccccc3C2=O)n1)C1CCCc2cccnc21,,CC#N,,CCN(C(C)C)C(C)C,,val
US20150094296A1,CCC(C(=O)[O-])(C(=O)OC(C)(C)C)c1ccc([N+](=O)[O-])cn1>>CCOC(=O)Cc1ccc([N+](=O)[O-])cn1,,CCOC(C)=O,,Cl,,val
US20040116465A1,CC(C)N.CCOc1ccc(CC(=O)Nc2cc(NC)ccc2[N+](=O)[O-])cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCOc1ccc(CC(=O)Nc2cc(N(C)C(=O)NC(C)C)ccc2[N+](=O)[O-])cc1,CN(C)c1ccncc1,ClCCCl,,,,val
US20050245540A1,O=C1c2ccccc2C(=O)N1CCCN1CCC(c2c[nH]c3ccccc23)CC1>>NCCCN1CCC(c2c[nH]c3ccccc23)CC1,,CCO,,NN,O,val
US20060084680A1,CCOC(=O)CC1CCc2cc(OC)ccc21>>COc1ccc2c(c1)CCC2CC(=O)O,,CCO,O,[Na+].[OH-],,val
US20110015175A1,COc1cc(N)ccc1-c1cnnc(C)c1.O=c1ccccn1C(=S)n1ccccc1=O>>COc1cc(N=C=S)ccc1-c1cnnc(C)c1,,ClCCl,,Cl,,val
US07176215B2,O=C(O)c1sc2c(ccc(=O)n2-c2ccccc2)c1-c1ccccc1>>O=c1ccc2c(-c3ccccc3)csc2n1-c1ccccc1,,C1COCCO1,,Cl,[Na+].[OH-],val
US20040142980A1,C[Si](C)(C)N[Si](C)(C)C.N#Cc1ccccc1Cl>>N=C(N)c1ccccc1Cl,,CCOCC,,Cl,[Li]CCCC,val
US05519040,Brc1nccs1.O=CC1CC1>>OC(c1nccs1)C1CC1,,CCOCC,,[Li]CCCC,,val
US05763552,CCO.O=S(=O)(F)OC(F)(F)C(F)(I)C(F)(F)F>>CCOC(=O)C(F)(I)C(F)(F)F,,O,,[F-].[K+],,val
US20080064696A1,CC1(C)OB(c2ccc(N)c(F)c2)OC1(C)C.Nc1cc(C(F)(F)F)ccc1F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC1(C)OB(c2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)c(F)c2)OC1(C)C,,ClCCl,O,CCN(CC)CC,,val
US06166006,Cc1ccccn1.O=C(Nc1ccc(CCl)cc1)C1=Cc2cc(-c3ccccc3)ccc2CC1>>Cc1cccc[n+]1Cc1ccc(NC(=O)C2=Cc3cc(-c4ccccc4)ccc3CC2)cc1.[Cl-],,CN(C)C=O,,,,val
US20090029955A1,CN1CCN(c2nc(S)c(C#N)c3c2CCC(C)(C)C3)CC1.NC(=O)CCl>>CN1CCN(c2nc3sc(C(N)=O)c(N)c3c3c2CCC(C)(C)C3)CC1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20080234255A1,CN1C(=O)C2CCCC2N(C2CCCC2)c2nc(Cl)ncc21.COc1cc(C(=O)O)ccc1N>>COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)C1CCCC1C(=O)N2C,,CCO,CCOC(C)=O,Cl,[Na+].[OH-],val
US20120178748A1,COC(=O)CC(C)c1nc2c3cccnc3ccc2n1C>>CC(CC(=O)O)c1nc2c3cccnc3ccc2n1C,,CC#N,O,[Li+].[OH-],,val
US04725608,NN1CC=CCC1.O=C(Nc1ccc(F)cc1)Oc1ccccc1>>O=C(Nc1ccc(F)cc1)NN1CC=CCC1,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US20130017194A1,C=O.NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CCCCN3)cc2)ncc1C(F)(F)F>>CN1CCCCC1c1ccc(Nc2ncc(C(F)(F)F)c(CCc3ccccc3CC(N)=O)n2)cc1,,CO,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110118245A1,COCCOc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC.Cc1ccc(-n2nc(C(F)(F)F)cc2NC(=O)Oc2ccccc2)cc1>>COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(F)(F)F)nn4-c4ccc(C)cc4)c3)c2cc1OC,CN(C)c1ccncc1,C1CCOC1,,,,val
US20090209476A1,Clc1cc(Cl)ncn1.OB(O)c1ccc(OC(F)(F)F)cc1>>FC(F)(F)Oc1ccc(-c2cc(Cl)ncn2)cc1,[Pd],,,,,val
US04507303,Cl.NCCCCN1CCN(c2ncccn2)CC1.O=C1OC(=O)C2C3CCC(CC3)C12>>Cl.O=C1C2C3CCC(CC3)C2C(=O)N1CCCCN1CCN(c2ncccn2)CC1,,c1ccncc1,,CC(C)O,,val
US20130059883A1,CCOC(=O)CCc1nc(-c2ccccc2)cs1>>OCCCc1nc(-c2ccccc2)cs1,,CO,O,[BH4-].[Na+],,val
US05516774,Cc1ccc(F)cc1C(=O)Cl.Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1>>Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1,,ClCCl,,CCN(CC)CC,,val
US20150005258A1,COC(=O)C1(CN(C)C(=O)OC(C)(C)C)CC1>>CN(CC1(C(=O)O)CC1)C(=O)OC(C)(C)C,,CO,,O,[Na+].[OH-],val
US06380387B1,COC(=O)[C@H](Cc1ccc(-c2cn(C)c(=O)n(C)c2=O)cc1)NC(=O)c1c(C)cccc1Cl>>Cc1cccc(Cl)c1C(=O)N[C@@H](Cc1ccc(-c2cn(C)c(=O)n(C)c2=O)cc1)C(=O)O,,CCO,,[Na+].[OH-],,val
US04448784,COc1ccc2c(c1)CCN2.N#Cc1cccc(CBr)c1>>COc1ccc2c(c1)CCN2Cc1cccc(C#N)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04859684,CC(=O)c1ccc(Cl)c([N+](=O)[O-])c1.CN>>CNc1ccc(C(C)=O)cc1[N+](=O)[O-],,CO,,,,val
US20130059856A1,CC(C)C#N.Fc1ccc(F)c(CBr)c1F>>CC(C)(C#N)Cc1c(F)ccc(F)c1F,,C1CCOC1,,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20070185175A1,CCOC(=O)c1ccc2nc(N)sc2c1>>Nc1nc2ccc(CO)cc2s1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06403610B1,COC(=O)C[C@H]1CN(CC#Cc2cccs2)CC[C@H]1CCC(O)c1ccnc2ccc(OC)cc12>>COc1ccc2nccc(C(O)CC[C@@H]3CCN(CC#Cc4cccs4)C[C@@H]3CC(=O)O)c2c1,,C1COCCO1,CCOCC,[Na+].[OH-],,val
US05648367,Cl.Cl.NCCON.O=C(CCCn1ccnc1)c1ccc(Cl)cc1>>Cl.Cl.NCCON=C(CCCn1ccnc1)c1ccc(Cl)cc1,,CCO,,c1ccncc1,,val
US20080275085A1,Cl.Nc1cc(C(=O)O)cc(C(F)(F)F)c1>>O=C(O)c1cc(Cl)cc(C(F)(F)F)c1,Cl[Cu],CC#N,,,,val
US20100087427A1,CCc1ccc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2N)C(C)C)cc1OCCCOC.O=S(=O)(Cl)Cc1ccccc1>>CCc1ccc(C(=O)N(C(C)C)C(N)[C@@H]2CNC[C@H]2S(=O)(=O)Cc2ccccc2)cc1OCCCOC,,O,,CC#N,CC#N,val
US20090048203A1,CN(C)C(=O)Cl.Nc1nc(O)nc2c1ncn2C1CCCO1>>CN(C)C(=O)Oc1nc(N)c2ncn(C3CCCO3)c2n1,,c1ccncc1,,CCN(CC)CC,,val
US20120252817A1,CC(C)(C)OC(=O)NC1(c2ccc(C(=N)NO)cn2)CC1.O=C(O)C1CC1>>CC(C)(C)OC(=O)NC1(c2ccc(-c3noc(C4CC4)n3)cn2)CC1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20130281434A1,Cc1cc2nc(Br)sc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C.OB(O)c1cncc(Br)c1>>Cc1cc2nc(-c3cncc(Br)c3)sc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US06376503B1,COC(=O)c1ccccc1N1CCC2(CC1)OCC(C)O2>>COC(=O)c1ccccc1N1CCC(=O)CC1,,Cl,O,O=C([O-])[O-].[Na+].[Na+],,val
US20150284396A1,C1CCNC1.CCCCc1nc(N)c2c(n1)c(C#CCCCC=O)cn2COCc1ccccc1>>CCCCc1nc(N)c2c(n1)c(C#CCCCCN1CCCC1)cn2COCc1ccccc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US06380218B1,N#Cc1ccc2c(c1)C(Br)(Br)C(=O)N2>>N#Cc1ccc2c(c1)CC(=O)N2,[Zn],CC(=O)O,,,,val
US20050222408A1,COc1ccc(C(=O)Cl)cc1.O=C(c1ccc([N+](=O)[O-])o1)N1CCNCC1>>COc1ccc(C(=O)N2CCN(C(=O)c3ccc([N+](=O)[O-])o3)CC2)cc1,,CCN(CC)CC,ClCCl,,,val
US20110118266A1,Cn1nc(N2CCNCC2)c(=O)n(C)c1=O.O=C(Cl)c1cc(C(F)(F)F)ccc1C(F)(F)F>>Cn1nc(N2CCN(C(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)CC2)c(=O)n(C)c1=O,,ClCCl,,CCN(CC)CC,O,val
US20090062251A1,CCNC(=O)CCC[NH2+]C.Cn1c2c(c3cc(C(=O)O)ccc31)CC(C1CCOCC1)CC2>>CCNC(=O)CCCN(C)C(=O)c1ccc2c(c1)c1c(n2C)CCC(C2CCOCC2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080125429A1,COC(=O)c1cc(Oc2ccc(-c3noc(C)n3)nc2)ccc1[N+](=O)[O-]>>Cc1nc(-c2ccc(Oc3ccc([N+](=O)[O-])c(C(=O)O)c3)cn2)no1,,C1CCOC1,CO,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US20070191364A1,CON(C)CCN(C1CCCCC1)C1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC2CCN(C(=O)OC(C)(C)C)CC2)CC1.Cl>>CON(C)CCN(C1CCCCC1)C1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC2CCNCC2)CC1.Cl,,CCOCC,,ClCCl,,val
US20090042891A1,Nc1cnc(Br)c(-c2cccc(F)c2)n1.c1cscn1>>Nc1cnc(-c2cncs2)c(-c2cccc(F)c2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(=O)N(C)C,,CC(=O)[O-].[K+],,val
US20080269218A1,Nc1ccc(CN2CCOCC2)cc1.S=C(Cl)Cl>>S=C=Nc1ccc(CN2CCOCC2)cc1,,C1CCOC1,,CCN(CC)CC,[Na+].[OH-],val
US20110257165A1,BrCBr.O=C(Cc1ccncc1)c1cccc([N+](=O)[O-])c1.S=C=S>>O=C(C(=C1SCS1)c1ccncc1)c1cccc([N+](=O)[O-])c1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US04628057,ClCc1cccs1.O=C(O)C1Cc2c([nH]c3ccccc23)CN1.S=C=S>>O=C(O)C1Cc2c([nH]c3ccccc23)CN1C(=S)SCc1cccs1,,CS(C)=O,,[Na+].[OH-],,val
US20060009439A1,CCOC(C)OC1CCC(C)(OC(C)OCC)C(OC(C)=O)C=CC(C)C(/C(C)=C/C=C/C(C)(CC2OC2C(C)C(CC)OC(C)OCC)OC(C)OCC)OC(=O)C1>>CCOC(C)OC1CCC(C)(OC(C)OCC)C(O)C=CC(C)C(/C(C)=C/C=C/C(C)(CC2OC2C(C)C(CC)OC(C)OCC)OC(C)OCC)OC(=O)C1,,CCOC(C)=O,CO,O=C([O-])[O-].[K+].[K+],,val
US20020072611A1,CC(C)(C)OC(=O)N1CCC(c2c[nH]c3ccc(C#N)cc23)CC1>>N#Cc1ccc2[nH]cc(C3CCNCC3)c2c1,,CO,,C1COCCO1,Cl,val
US20160016948A1,CC(OS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)F.Clc1cc2[nH]cc(I)c2cn1>>CC(n1cc(I)c2cnc(Cl)cc21)C(F)(F)F,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120190665A1,C[Si](C)(C)COCCn1ncc([N+](=O)[O-])c1-c1cccc(Br)c1>>C[Si](C)(C)COCCn1ncc(N)c1-c1cccc(Br)c1,[Fe],CCO,ClCCl,O,[Cl-].[NH4+],val
US20020143034A1,CC(C)(C)OC(=O)N[C@H](CO)Cc1ccc(Oc2ncccc2C#N)cc1.OO>>CC(C)(C)OC(=O)N[C@H](CO)Cc1ccc(Oc2ncccc2C(N)=O)cc1,,CS(C)=O,,Cl,[Na+].[OH-],val
US20040058903A1,CC(=O)Nc1cccc(CCc2ccc(N)cc2)n1.O=C(Cl)c1ccccc1-c1ccc(C(F)(F)F)cc1>>CC(=O)Nc1cccc(CCc2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)n1,,C1CCOC1,O,CCN(CC)CC,CCOC(C)=O,val
US20100197651A1,CN(C)C=CC(=O)c1nn(-c2cccc(C(F)(F)F)c2)ccc1=O.NNc1ccc(Cl)cc1>>O=c1ccn(-c2cccc(C(F)(F)F)c2)nc1-c1ccnn1-c1ccc(Cl)cc1,,CCO,,CCN(CC)CC,Cl,val
US20100022515A1,COc1cccc(C(C)(C)C#N)c1>>COc1cccc(C(C)(C)CN)c1,,C1CCOC1,,B,CO,val
US07326718B2,CNC.Cc1nc2c(N[C@@H]3c4ccccc4C[C@H]3O)cc(C(=O)O)cn2c1C>>Cc1nc2c(N[C@@H]3c4ccccc4C[C@H]3O)cc(C(=O)N(C)C)cn2c1C,,ClCCl,,,,val
US20140256715A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C1COCC(CF)(c2cc(Br)ccc2F)N1>>FCC1(c2cc(Br)ccc2F)COCC(=S)N1,,C1CCOC1,,,,val
US20040122016A1,Nc1ccccc1.O=C(CCl)Nc1nc(-c2ccncc2)cs1>>O=C(CNc1ccccc1)Nc1nc(-c2ccncc2)cs1,,CCCO,,,,val
US04749812,CC(C)c1ccc(N)cc1Cl.CC1(C(=O)Cl)CC1>>CC(C)c1ccc(NC(=O)C2(C)CC2)cc1Cl,,CCN(CC)CC,,c1ccccc1,,val
US20020037888A1,C=CCN1CCCCC(CC)(c2cccc(OC)c2)C1=O.O=[O+][O-]>>CCC1(c2cccc(OC)c2)CCCCN(CCO)C1=O,,CO,,[BH4-].[Na+],,val
US20110269780A1,CCOC(=O)C[C@@H](Nc1nc(C)ccc1[N+](=O)[O-])c1ccccc1.CN(C)C=O.Cc1cc(C)c2c(CBr)nsc2c1>>CCOC(=O)C[C@H](c1ccccc1)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2cnccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04673684,Br[Mg]c1ccccc1.CC(=O)c1ccc(Cl)cc1>>CC(O)(c1ccccc1)c1ccc(Cl)cc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20040180939A1,CC(C)(C)c1cc(C#N)cc(C(C)(C)C)c1>>CC(C)(C)c1cc(CN)cc(C(C)(C)C)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040204397A1,COC(=O)[C@@H](Cc1ccc2[nH]c(=O)oc2c1)NC(=O)OCc1ccccc1.O=C1CCC(=O)N1Cl>>COC(=O)[C@@H](Cc1cc2oc(=O)[nH]c2cc1Cl)NC(=O)OCc1ccccc1,,CC(=O)O,,,,val
US05362878,CCCCCCCCC(SCCCCCC)C(=O)Nc1c(NC(C)=O)ccc2ncccc12>>CCCCCCCCC(SCCCCCC)C(=O)Nc1c(N)ccc2ncccc12,,CC(C)O,,Cl,,val
US05925632,CC(C)CNC(=O)C(Br)CCBr>>CC(C)CN1CCC(Br)C1=O,,ClCCl,,[Na+].[OH-],,val
US20100240669A1,N#Cc1ncc(F)cc1F.Nc1ccccc1Cl>>NCc1ncc(Nc2ccccc2Cl)cc1F,[Ni],,,,,val
US20160002224A1,COC(=O)CCC(=O)N(C)OC.C[Si](C)(C)CCOCn1c(Cl)cc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc21>>COC(=O)CCC(=O)c1cc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc2n1COCC[Si](C)(C)C,,C1CCOC1,C1CCOC1,[Li]C(C)(C)C,,val
US20060052420A1,COc1ccc2cc(-c3csc(Cc4c(Cl)cccc4Cl)n3)ccc2c1>>Oc1ccc2cc(-c3csc(Cc4c(Cl)cccc4Cl)n3)ccc2c1,,CC(=O)O,,Br,,val
US04440774,COc1ccc(CC(C)=O)cc1OC.[BH3-]C#N>>COc1ccc(CC(C)N)cc1OC,,CO,,Cl,,val
US20150225412A1,CC(C)(C)OC(=O)N1CCCC1Cn1c(NC(=O)c2ccc(Cl)cc2)nc2ccccc21>>O=C(Nc1nc2ccccc2n1CC1CCCN1)c1ccc(Cl)cc1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20100278833A1,CS(=O)(=O)OS(C)(=O)=O.NC(=O)c1sc(-n2cnc3cnc(CO)cc32)cc1OCc1ccccc1C(F)(F)F>>CS(=O)(=O)OCc1cc2c(cn1)ncn2-c1cc(OCc2ccccc2C(F)(F)F)c(C(N)=O)s1,,ClCCl,,CCN(CC)CC,,val
US20110105462A1,CCCCN.Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(F)cc3O2)cc1>>CCCCNCC1COc2c(F)cc(F)cc2O1,,CC#N,,,,val
US20110201584A1,C[C@]12CC[C@H](OC(=O)Oc3ccc([N+](=O)[O-])cc3)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccc(=O)oc3)CC[C@]12O.NCCCC(=O)O>>C[C@]12CC[C@H](OC(=O)NCCCC(=O)O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccc(=O)oc3)CC[C@]12O,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120295882A1,CC(C)(C)OC(=O)NCCc1c[nH]c2cc(I)ccc12.O=C1CCOCC1>>Ic1ccc2c3c([nH]c2c1)C1(CCOCC1)NCC3,,ClCCCl,,O=C(O)C(F)(F)F,,val
US04902698,Nc1ccc(CCCCC(=O)O)nc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=C(O)CCCCc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cn1,,c1ccncc1,,,,val
US05240938,BrC(Br)(Br)Br.COC(=O)C(Cc1ccccc1)Oc1ccc(CO)cc1>>COC(=O)C(Cc1ccccc1)Oc1ccc(CBr)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05834506,CN(C)S(=O)(=O)Cl.Cc1cc(SC#N)c(C(C)(C)C)cc1O>>Cc1cc(SC#N)c(C(C)(C)C)cc1OS(=O)(=O)N(C)C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120232112A1,CCOC(=O)c1cc(N)n(-c2ccccc2)n1.CS(=O)(=O)Cl>>CS(=O)(=O)Nc1cc(C(=O)O)nn1-c1ccccc1,,C1CCOC1,,CCN(CC)CC,[Na+].[OH-],val
US20150166480A1,CC(C)(C)OC(=O)N1CCC(COc2ccc(Br)cc2F)CC1.Cl>>Cl.Fc1cc(Br)ccc1OCC1CCNCC1,,CO,,,,val
US20110204333A1,O=[N+]([O-])c1ccc2oc3ccccc3c2c1>>Nc1ccc2oc3ccccc3c2c1,[Pd],CCOC(C)=O,,[H][H],,val
US09000172B2,O=C1CCCCN1c1cccc2cnccc12>>O=C1CCCCN1c1cccc2c1CCNC2,O=[Pt]=O,CCO,,,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n([C@@H]2CC[C@@H](OCC3(O)CCC3)CC2)c2ncnn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2F)c(=O)n([C@@H]2CC[C@@H](OCC3(O)CCC3)CC2)c2ncnn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US05057614,CC(=O)OC(C)=O.OCCn1ccc2ccccc21>>CC(=O)OCCn1ccc2ccccc21,,CCOCC,,O,c1ccncc1,val
US20140243283A1,CC(=O)OC[C@H]1O[C@H](CC(=O)Nc2cccc(NC(=O)C[C@H]3O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3OC(C)=O)c2)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>O=C(C[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O)Nc1cccc(NC(=O)C[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)c1,,CO,,CO[Na],,val
US20110294793A1,CC(C)(C)OC(=O)NCc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cc(Cl)cc(Cl)c2O)c1>>NCc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cc(Cl)cc(Cl)c2O)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090286768A1,C[Mg]Br.O=C(c1ccccc1)c1ccc(Br)c(F)c1>>CC(O)(c1ccccc1)c1ccc(Br)c(F)c1,,C1CCOC1,,,,val
US20100075998A1,CCOC(=O)c1cn(C)c2c1CCc1[nH]ncc1-2>>CCOC(=O)c1cn(C)c2c1ccc1[nH]ncc12,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20090131433A1,C1CCNC1.O=Cc1cccc(O)c1Cl>>Oc1cccc(CN2CCCC2)c1Cl,,ClCCl,O,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150274747A1,CS(=O)(=O)Cl.OC1COC2C(OCCOCc3ccccc3)COC12>>CS(=O)(=O)OC1COC2C(OCCOCc3ccccc3)COC12,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US04238611,COc1cc(Sc2ccccc2CO)ccc1Cl.O=S(Cl)Cl>>COc1cc(Sc2ccccc2CCl)ccc1Cl,,O,,c1ccncc1,,val
US20150175594A1,O=C(Cl)c1ccccc1.OC1CCC(O)CC1>>OC1CCC(OCc2ccccc2)CC1,,ClC(Cl)Cl,ClCCl,c1ccncc1,,val
US20100292239A1,CC(CO)NC(=O)c1cn(C)nc1C(F)F.FC(F)(F)c1cnc(Br)c(Cl)c1>>CC(COc1ncc(C(F)(F)F)cc1Cl)NC(=O)c1cn(C)nc1C(F)F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150307497A1,N#Cc1ccc(CN2Cc3cccc(Oc4ccccc4)c3C2=O)cc1.OO>>NC(=O)c1ccc(CN2Cc3cccc(Oc4ccccc4)c3C2=O)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070203080A1,CC(=O)Cl.COc1cccc(OC)c1C>>COc1ccc(C(C)=O)c(OC)c1C,Cl[Ti](Cl)(Cl)Cl,c1ccccc1,,Cl,,val
US20040204450A1,CCOC(=O)N1c2cc(OC)c(OC)cc2C(=[N+]=[N-])CC1C.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CCOC(=O)N1c2cc(OC)c(OC)cc2C(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)=CC1C,,CCOCC,,CCN(C(C)C)C(C)C,,val
US20120028973A1,CC(C)[Si](OC[C@H](CO)Oc1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)(C(C)C)C(C)C.II>>CC(C)[Si](OC[C@H](CI)Oc1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)(C(C)C)C(C)C,,c1ccccc1,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040077669A1,CC#CCO.CSc1cc(Cl)ncn1>>CC#CCOc1cc(SC)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20140235660A1,COc1ccc2c(Oc3ccc(/C=C/C(N)=O)cc3)c(-c3ccc(F)cc3)sc2c1.C[Si](C)(C)N=[N+]=[N-]>>COc1ccc2c(Oc3ccc(/C=C/c4nnn[nH]4)cc3)c(-c3ccc(F)cc3)sc2c1,,COCCOC,,,,val
US20120094997A1,COC(=O)c1ccc2ccn(CCNc3cccc(-n4cccn4)c3)c(=O)c2c1.O=C(Cl)C1CC1>>COC(=O)c1ccc2ccn(CCN(C(=O)C3CC3)c3cccc(-n4cccn4)c3)c(=O)c2c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20050277670A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@H](CCN)N1CCC(Nc2ccc(O[Si](C)(C)C(C)(C)C)cc2)CC1>>C[C@H](CCNC(=O)OC(C)(C)C)N1CCC(Nc2ccc(O[Si](C)(C)C(C)(C)C)cc2)CC1,,C1CCOC1,,,,val
US20150329538A1,CC(C)(C)N.O=C1NCCc2[nH]c(-c3cccc4ncc(F)nc34)cc21>>CC(C)(C)Nc1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1,,CS(C)=O,ClCCl,,,val
US20100256101A1,CC(=O)N(C)C.Fc1ccc(Br)nc1>>CC(=O)c1ccc(F)cn1,,CCOCC,,[Li]C(C)CC,,val
US20050075272A1,COc1ccc(N(C(=O)N[C@@H](C)c2ccccc2)C(C)c2cnc(Cl)nc2Cl)cc1>>COc1ccc(N2C(=O)N([C@@H](C)c3ccccc3)c3nc(Cl)ncc3C2C)cc1,,C1CCOC1,CCOC(C)=O,CC(C)(C)[O-].[K+],,val
US20090042929A1,Clc1ccc(Cl)c(SCc2cn(C34CC5CC(CC(C5)C3)C4)nn2)c1.O=C(OO)c1cccc(Cl)c1>>O=S(Cc1cn(C23CC4CC(CC(C4)C2)C3)nn1)c1cc(Cl)ccc1Cl,,ClCCl,,,,val
US04066773,CCOC(=O)CN(CCOC)C(=O)[C@H](CCCNC(=N)N)N[N+](=O)[O-].Cl>>CCOC(=O)CN(CCOC)C(=O)[C@@H](N)CCCNC(=N)N.Cl,[Pd],CCO,,[H][H],,val
US04556711,O=C(Nc1ccc(-c2c[nH]c(=O)cn2)cc1)c1cccc([N+](=O)[O-])c1>>Nc1cccc(C(=O)Nc2ccc(-c3c[nH]c(=O)cn3)cc2)c1,[Pd],CCO,,C1=CCCCC1,,val
US20110183940A1,C[C@H]1CO[C@@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(OCOC(=O)Oc4ccc([N+](=O)[O-])cc4)c3C(=O)N12.O=C1CCCN1CCO>>C[C@H]1CO[C@@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(OCOC(=O)OCCN4CCCC4=O)c3C(=O)N12,CN(C)c1ccncc1,,,CCN(CC)CC,,val
US20130237525A1,CCOc1cccc(OCC)c1CO>>CCOc1cccc(OCC)c1C=O,O=[Mn]=O,ClC(Cl)Cl,,,,val
US20120202783A1,CCOC(=O)C1=C(NCc2ccccc2)CN(C(=O)OC(C)(C)C)CC1>>CCOC(=O)C1CCN(C(=O)OC(C)(C)C)CC1NCc1ccccc1,,Cc1ccccc1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20090192156A1,COC1(C)CCNCC1.O=C(O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F>>COC1(C)CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040058923A1,CI.CS(=O)(=O)Nc1cccc(CC(=O)NCC2CN(Cc3ccc(Cl)c(Cl)c3)CCO2)c1>>CN(c1cccc(CC(=O)NCC2CN(Cc3ccc(Cl)c(Cl)c3)CCO2)c1)S(C)(=O)=O,,CC(C)=O,,CO,O=C([O-])[O-].[K+].[K+],val
US20110218197A1,Cc1nc(-c2ccccc2C(F)(F)F)nc(NC(=O)c2cc(C(C)(C)C)nn2C)c1[N+](=O)[O-]>>Cc1nc(-c2ccccc2C(F)(F)F)nc(NC(=O)c2cc(C(C)(C)C)nn2C)c1N,[Fe],CCO,,O,[Cl-].[NH4+],val
US20140206681A1,COC(=O)C1CCC(CCNCc2ccc(OC)cc2OC)NC1.O=C(n1ccnc1)n1ccnc1>>COC(=O)C1CCC2CCN(Cc3ccc(OC)cc3OC)C(=O)N2C1,,C1CCOC1,,,,val
US20100179139A1,FC(F)(F)c1cc2c(Cl)ccnc2[nH]1.OB(O)c1ccc(F)nc1>>Fc1ccc(-c2ccnc3[nH]c(C(F)(F)F)cc23)cn1,,CC(C)O,,O=C([O-])O.[Na+],,val
US20090069222A1,CC(C)(C)OC(=O)NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NCCCCNC(=O)[C@@H](N)Cc1c[nH]c2ccccc12,[Pd],CN(C)C=O,CO,,,val
US20110105461A1,CS(=O)(=O)c1ccc2c(c1)OC(CO)CC2.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCC2CCc3ccc(S(C)(=O)=O)cc3O2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20010039344A1,COC(=O)c1ccc(N)nc1.O=C(O)C(CC1CCCC1)c1ccc([N+](=O)[O-])cc1>>COC(=O)c1ccc(NC(=O)C(CC2CCCC2)c2ccc([N+](=O)[O-])cc2)nc1,CN(C)C=O,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20120302610A1,CCOC(=O)CCNC(=O)c1ccc(-c2cc(Cl)ccc2C=O)cn1.Nc1ccc(-c2ccc(Cl)cc2Cl)cc1>>CCOC(=O)CCNC(=O)c1ccc(-c2cc(Cl)ccc2CNc2ccc(-c3ccc(Cl)cc3Cl)cc2)cn1,,CCOC(C)=O,ClCCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US03944560,CC(Cl)C#N.O=Cc1cc(Cl)ccc1O>>CC(C#N)Oc1ccc(Cl)cc1C=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100120806A1,CS(=O)(=O)O.Cc1cc(NC(=O)C2(C(=O)Nc3ccc(F)cc3)CC2)c(F)cc1Oc1ccnc(-c2cnn(C)c2)c1>>CS(=O)(=O)O.Cc1cc(NC(=O)C2(C(=O)Nc3ccc(F)cc3)CC2)c(F)cc1Oc1ccnc(-c2cnn(C)c2)c1,,ClCCl,,,,val
US04523012,C=C(Cl)C(=O)OC.O=C(O)CS>>COC(=O)C(Cl)CSCC(=O)O,,O,,Cl,[Na+].[OH-],val
US20090018122A1,CCc1nc2cnc3ccc(OCc4ccccc4)cc3c2n1C.O=C(OO)c1cccc(Cl)c1>>CCc1nc2c[n+]([O-])c3ccc(OCc4ccccc4)cc3c2n1C,,ClC(Cl)Cl,,,,val
US20100311750A1,CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)OC(C)(C)C>>CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06593314B1,O=C(O)[C@@]1(O)C[C@@H](O)[C@H](O)[C@H](O)C1.O=Cc1ccccc1>>O=C1O[C@@H]2C[C@@]1(O)C[C@H]1OC(c3ccccc3)O[C@@H]21,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20160145247A1,BrCc1cc(Br)cc2c1OCO2.CC(C)(C)OC(=O)Cc1ccccc1O>>CC(C)(C)OC(=O)Cc1ccccc1OCc1cc(Br)cc2c1OCO2,,CN(C)C=O,,[I-].[K+],,val
US20160024121A1,Clc1ncccn1.O=C(O)c1cccc2c1OB(O)[C@@H](NC(=O)C1CNC1)C2>>O=C(O)c1cccc2c1OB(O)[C@@H](NC(=O)C1CN(c3ncccn3)C1)C2,,CN(C)C=O,,,,val
US04745116,CCC(=O)c1c(O)c(C(=O)O)c(CC)oc1=O>>CCc1cc(O)cc(=O)o1,,O,O=S(=O)(O)O,,,val
US20150315172A1,Cn1cc(C(=O)N2CCC(c3ccc(F)cc3)CC2)c(O)cc1=O.O=[N+]([O-])O>>Cn1cc(C(=O)N2CCC(c3ccc(F)cc3)CC2)c(O)c([N+](=O)[O-])c1=O,,CC(=O)O,O,,,val
US04205085,CCOC(=O)C(C)OS(=O)(=O)c1ccc(C)cc1.O=C([O-])c1ccc(NCCCCCCCCCCCCCCCC(F)(F)F)cc1>>CCOC(=O)C(C)OC(=O)c1ccc(NCCCCCCCCCCCCCCCC(F)(F)F)cc1,,O,,CCO,,val
US20150223460A1,Cc1cc(-c2nn(C)c(C(=O)O)c2C)ccc1OCc1c(C2CC2)cccc1-n1nnn(C)c1=O.O=C(Cl)C(=O)Cl>>Cc1cc(-c2nn(C)c(C(=O)Cl)c2C)ccc1OCc1c(C2CC2)cccc1-n1nnn(C)c1=O,,CN(C)C=O,,C1CCOC1,,val
US20030130238A1,CC(C)(C)OC(=O)C1N(S(=O)(=O)c2ccc(O)cc2)CCSC1(C)C.CC=C=CCO>>CC=C=CCOc1ccc(S(=O)(=O)N2CCSC(C)(C)[C@@H]2C(=O)OC(C)(C)C)cc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05891358,CC[C@H](C)COc1ccc(-c2ccc(C(=O)O)cc2)cc1.O=[N+]([O-])O>>CC[C@H](C)COc1ccc(-c2ccc(C(=O)O)cc2)cc1[N+](=O)[O-],,CC(=O)O,,O=S(=O)(O)O,,val
US03978066,CCOC1=NCc2c[nH]c3cccc1c23.CN(C)CCCN>>CN(C)CCCNC1=NCc2c[nH]c3cccc1c23,,CCO,,Cl,,val
US20140179715A1,CN1CCn2c1cc(Cl)nc2=O.N#Cc1cncc(Oc2ccc(CO)cc2F)c1>>CN1CCn2c1cc(OCc1ccc(Oc3cncc(C#N)c3)c(F)c1)nc2=O,,C1CCOC1,,[H-].[Na+],,val
US20110230463A1,CC(C)(C)OC(=O)N1CC(C#N)(CO)C1.CCN(CC)S(F)(F)F>>CC(C)(C)OC(=O)N1CC(C#N)(CF)C1,,ClCCl,,O=C([O-])O.[Na+],,val
US20090264406A1,C=C[Sn](CCCC)(CCCC)CCCC.Cn1cc(-c2ccc3ncc(Cc4ccc5ncc(Br)n5c4)n3n2)cn1>>C=Cc1cnc2ccc(Cc3cnc4ccc(-c5cnn(C)c5)nn34)cn12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20090143366A1,NCCN.O=Cc1cc(Br)ccc1F>>Brc1ccc2c(c1)C=NCCN2,,O,,,,val
US20060257987A1,CCc1ccc(OCC[C@H](C)O)c(C(=O)c2ccccc2)c1.CS(=O)(=O)Cl>>CCc1ccc(OCC[C@H](C)OS(C)(=O)=O)c(C(=O)c2ccccc2)c1,,ClCCl,,CCN(CC)CC,,val
US20110311466A1,O=C(c1ccccc1)N1CC(c2ccc(OCc3ccccc3)cc2OCc2ccccc2)C1>>O=C(c1ccccc1)N1CC(c2ccc(O)cc2O)C1,[Pd],CO,,,,val
US20160107997A1,CCN1CCc2cccc(N(CC(=O)N(CCN(C)C)Cc3ccccc3)C(=O)C(F)(F)F)c2C1>>CCN1CCc2cccc(NCC(=O)N(CCN(C)C)Cc3ccccc3)c2C1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20120316147A1,COC(=O)[C@H](CC1CC1)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@H](CO)CC1CC1,,CO,,O,[BH4-].[Na+],val
US20090028787A1,CC(C)(C)OC(=O)N1CCN(c2ccc(-c3nc4ccc([N+](=O)[O-])cc4s3)cn2)CC1.O=C(O)C(F)(F)F>>CN1CCN(c2ccc(-c3nc4ccc([N+](=O)[O-])cc4s3)cn2)CC1.O=C(O)C(F)(F)F,,ClCCl,,CO,,val
US20070254881A1,CC(=O)c1ncc[nH]1.Cc1ccc(S(=O)(=O)Cl)cc1>>CC(=O)c1nccn1S(=O)(=O)c1ccc(C)cc1,,ClCCl,O,CCN(CC)CC,CCOC(C)=O,val
US20160145247A1,COC(=O)Cc1cccc(Br)c1OCc1cccc(-c2cccc(CNC(=O)OC(C)(C)C)c2)c1>>NCc1cccc(-c2cccc(COc3c(Br)cccc3CC(=O)O)c2)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20100273792A1,CC1(C)COB(B2OCC(C)(C)CO2)OC1.COc1ccc(-c2ccc(Cl)cc2)c(-c2ccc3cc(Br)ccc3n2)c1>>COc1ccc(-c2ccc(Cl)cc2)c(-c2ccc3cc(B4OCC(C)(C)CO4)ccc3n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CS(C)=O,CC(=O)[O-].[K+],,val
US20120258949A1,COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCCN(C(=O)OC(C)(C)C)CC1)O2>>O=C(O)/C=C/c1ccc2c(c1)C(=O)CC1(CCCNCC1)O2,,CC(=O)O,,Cl,,val
US20150344473A1,N#Cc1cc(Br)ccc1F.OC1COC1>>N#Cc1cc(Br)ccc1OC1COC1,,CN(C)C=O,,O,[H-].[Na+],val
US20110224188A1,CC(C)(C)OC(=O)N1CC[C@@H](c2cc(O)[nH]n2)C1>>Oc1cc([C@@H]2CCNC2)n[nH]1,,C1COCCO1,ClCCl,Cl,,val
US20100016361A1,CCBr.CCOC(=O)c1coc2cc(O)ccc12>>CCOC(=O)c1coc2cc(OCC)ccc12,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040152742A1,O=C(COc1ccc(C(F)(F)F)cc1Cl)Nc1ccc(CO)c(Cl)c1.O=S(Cl)Cl>>O=C(COc1ccc(C(F)(F)F)cc1Cl)Nc1ccc(CCl)c(Cl)c1,,Cc1ccccc1,,,,val
US20100292207A1,CC(C)(C)OC(=O)N1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1.CCOC(=O)Cl>>CCOC(=O)n1nc(NC(=O)c2ccc(N3CCNCC3)cc2NC2CCOCC2)c2cc(Cc3cc(F)cc(F)c3)ccc21,,C1CCOC1,ClCCl,,,val
US20070249670A1,COC(=O)[C@@H](NC(=O)c1sc(-c2ccc(OC)cc2)nc1N)C1CCCCC1.O=C=Nc1c(Cl)cc(Cl)cc1Cl>>COc1ccc(-c2nc(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)c(C(=O)N[C@H](C(=O)O)C3CCCCC3)s2)cc1,,Cc1ccccc1,,,,val
US20120015963A1,CC(=O)Cl.Cc1ccc(Nc2ncc3cnn(C[C@@H]4CC[C@H](N)CC4)c3n2)cc1S(N)(=O)=O>>CC(=O)N[C@@H]1CC[C@H](Cn2ncc3cnc(Nc4ccc(C)c(S(N)(=O)=O)c4)nc32)CC1,,C1CCOC1,,,,val
US20120077799A1,CC(C)Oc1ccc(-c2cccnc2N)cc1.O=S(=O)(Cl)CCCl>>CC(C)Oc1ccc(C2=CC=CN3CCS(=O)(=O)N=C23)cc1,,C1CCOC1,CCCCCC,O,[H-].[Na+],val
US20040209897A1,Br.BrBr.CC(=O)c1ccnc(-c2ccccc2F)c1>>Br.O=C(CBr)c1ccnc(-c2ccccc2F)c1,,CC(=O)O,,,,val
US20040067955A1,Cc1nc(-c2ccccc2)c(-c2ccc(=O)n(C(C)C)n2)cc1NC(=O)OC(C)(C)C>>Cc1nc(-c2ccccc2)c(-c2ccc(=O)n(C(C)C)n2)cc1N,,CCOC(C)=O,,Cl,,val
US20140275070A1,Cc1ccc2c(c1)cc(C#N)n2C[C@@H](CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C.O=C1CCC(=O)N1Br>>CC(C)(C)[Si](C)(C)OC[C@H](Cn1c(C#N)cc2cc(CBr)ccc21)O[Si](C)(C)C(C)(C)C,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,,,val
US20050261291A1,C=CC(C)=O.CC1(C)CC(c2ccccc2N2CCNCC2)CC(C)(C)C1>>CC(=O)CCN1CCN(c2ccccc2C2CC(C)(C)CC(C)(C)C2)CC1,,CCOC(C)=O,,ClC(Cl)Cl,,val
US20150225369A1,CNC(=O)c1cc(Cl)ccn1.Cc1cc(C#N)ccc1O>>CNC(=O)c1cc(Oc2ccc(C#N)cc2C)ccn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120088750A1,CCNC(=O)Nc1nc2cc(-c3cnc(N4CCC(C)(C(=O)OCC)CC4)nc3)cc(-c3cn(C[Si](C)(C)C)nn3)c2s1>>CCNC(=O)Nc1nc2cc(-c3cnc(N4CCC(C)(C(=O)OCC)CC4)nc3)cc(-c3cn(C)nn3)c2s1,O,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090088428A1,CCOC(=O)C1(Cc2c(Cl)cc(OCc3ccccc3)cc2Cl)CCN(C2CCc3nc[nH]c3C2)C1=O>>O=C(O)C1(Cc2c(Cl)cc(OCc3ccccc3)cc2Cl)CCN(C2CCc3nc[nH]c3C2)C1=O,,CO,,[Na+].[OH-],,val
US05098892,C[C@H](N)C(=O)N(CC(=O)O)C1Cc2ccccc2C1.O=C(O)C(=O)Cc1ccccc1>>C[C@H](NC(Cc1ccccc1)C(=O)O)C(=O)N(CC(=O)O)C1Cc2ccccc2C1,,[K+],[OH-],[BH3-]C#N.[Na+],,val
US20070232583A1,Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2nc(-c3ccc(S(=O)(=O)NC(C)(C)C)s3)cs2)n1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2nc(-c3ccc(S(N)(=O)=O)s3)cs2)n1,,O=C(O)C(F)(F)F,,,,val
US20040171881A1,C#Cc1cccc(C2(NC[C@@H](O)[C@@H](N)Cc3cc(F)cc(F)c3)CC2)c1.CCCN(CCC)c1cc(C(=O)O)ccn1>>C#Cc1cccc(C2(NC[C@@H](O)[C@H](Cc3cc(F)cc(F)c3)NC(=O)c3ccnc(N(CCC)CCC)c3)CC2)c1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20080004309A1,CCOC(=O)c1ncc2sc(-c3ccccc3)nc2c1O.O=C1CCC(=O)N1Br>>CCOC(=O)c1nc(Br)c2sc(-c3ccccc3)nc2c1O,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US06191150B1,C=C(C)CBr.CCC[C@@H](O)CC(=O)OC>>C=C(C)C[C@@H](C(=O)OC)[C@H](O)CCC,,C1CCOC1,CN(C)P(=O)(N(C)C)N(C)C,CC(C)NC(C)C,[Li]CCCC,val
US20120302599A1,CC(C)(C)OC(=O)N[C@@H](Cc1cn(Cc2ccccc2)nc1[N+](=O)[O-])C(=O)OCC(F)(F)F>>CC(C)(C)OC(=O)N[C@H]1Cc2cn(Cc3ccccc3)nc2N(O)C1=O,[Pt],c1ccncc1,,,,val
US20110172224A1,Cl.Clc1cc(Nc2ncnc3sc4c(c23)CCC2(C4)OCCO2)ccc1OCc1ccccn1>>Cl.O=C1CCc2c(sc3ncnc(Nc4ccc(OCc5ccccn5)c(Cl)c4)c23)C1,,CC(=O)O,O,,,val
US20160090374A1,CC(=O)N[C@H]1CCN(c2nc(Cl)nc3c2CCC3)C1.N#Cc1cc(N)cc(N)c1>>CC(=O)N[C@H]1CCN(c2nc(Nc3cc(N)cc(C#N)c3)nc3c2CCC3)C1.Cl,,CCOC(C)=O,,CCCCO,,val
US20070129358A1,OC(CC1CCOc2ccccc21)C(F)(F)F>>O=C(CC1CCOc2ccccc21)C(F)(F)F,,CCOCC,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20100240620A1,C/C(N)=C/C#N.CC(=O)Cc1nc(C)cs1.COc1ncccc1C=O>>COc1ncccc1C1C(C#N)=C(C)NC(C)=C1c1nc(C)cs1,,CC(C)O,,,,val
US20040009995A1,CC1(C)OBOC1(C)C.Cc1cc(O)cc(C)c1Br>>Cc1cc(O)cc(C)c1B1OC(C)(C)C(C)(C)O1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,CCN(CC)CC,,val
US20070254866A1,CCOC(=O)c1cn(Cc2ccccc2)c2c(OC)c(F)c(F)c(N)c2c1=O>>COc1c(F)c(F)c(N)c2c(=O)c(C(=O)O)cn(Cc3ccccc3)c12,,CCO,,[Na+].[OH-],,val
US20090029994A1,C=C(C)c1ccc(OC)c(Br)n1.COc1cc(CN(Cc2cc(C#N)cc(C(F)(F)F)c2)c2ncc(OCCCC(=O)OC(C)(C)C)cn2)c(B2OC(C)(C)C(C)(C)O2)cc1OC>>C=C(C)c1ccc(OC)c(-c2cc(OC)c(OC)cc2CN(Cc2cc(C#N)cc(C(F)(F)F)c2)c2ncc(OCCCC(=O)OC(C)(C)C)cn2)n1,,C1COCCO1,O,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20060217372A1,COc1cccc(CC(=O)N(C)CC(OC)OC)c1>>COc1ccc2c(c1)CC(=O)N(C)C=C2,,CC(=O)O,ClCCl,Cl,,val
US04069321,CC(=CC=CC(C)(C)F)[C@H]1CC[C@H]2[C@@H]3CCC4CC(=O)C5OC5[C@]4(C)[C@H]3CC[C@]12C>>C[C@H](CCCC(C)(C)F)[C@H]1CC[C@H]2[C@@H]3C=CC4=C[C@@H](O)C[C@H](O)[C@]4(C)[C@H]3CC[C@]12C,,CCOC(C)=O,,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20090221587A1,CNc1c([N+](=O)[O-])cc(C(=O)O)c(F)c1Cl.CO>>CNc1c([N+](=O)[O-])cc(C(=O)OC)c(F)c1Cl,,C1CCOC1,CO,C[Si](C)(C)C=[N+]=[N-],,val
US20140121198A1,CC(C)(C)OC(=O)NS(C)(=O)=O.N#CC[C@@H]1CC[C@@H](n2c(CCl)nc3cnc4ccsc4c32)CC1>>CC(C)(C)OC(=O)N(Cc1nc2cnc3ccsc3c2n1[C@@H]1CC[C@@H](CC#N)CC1)S(C)(=O)=O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20140134271A1,CI.CN(C(=O)Nc1nc(OCC(F)(F)F)cc(OCC(F)(F)F)n1)c1ccc(C(F)(F)F)s1>>CN(C(=O)N(C)c1ccc(C(F)(F)F)s1)c1nc(OCC(F)(F)F)cc(OCC(F)(F)F)n1,,C1CCOC1,,[H-].[Na+],,val
US20070099901A1,CCCc1nc2cnc3ccccc3c2n1CCCC=O>>CCCc1nc2cnc3ccccc3c2n1CCCCO,,CCO,,[BH4-].[Na+],,val
US05300509,CCOc1nc(C)nc(O)c1NC(=O)c1ccco1>>CCOc1nc(C)nc2oc(-c3ccco3)nc12,,O=P(Cl)(Cl)Cl,,CN(C)c1ccccc1,,val
US20070010556A1,CC(C)(C)OC(=O)N1CCC[C@H](N)C1.O=S(=O)(Cl)c1ccc(Cl)s1>>CC(C)(C)OC(=O)N1CCC[C@H](NS(=O)(=O)c2ccc(Cl)s2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090036492A1,CC[Sn](CC)(CC)CC.O=C1CCCc2c(F)cc(Br)cc21>>CCc1cc(F)c2c(c1)C(=O)CCC2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20050267133A1,CC(C)(C)OC(=O)Nc1ccc(/C=N/Nc2ncnc3c2cnn3-c2ccccc2)cn1.O=C(O)C(F)(F)F>>Nc1ccc(C=NNc2ncnc3c2cnn3-c2ccccc2)cn1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04963670,C[Si](C)(C)C(C(N)=O)[Si](C)(C)C.NCC(O)c1ccccc1>>C[Si](C)(C)OC(CN)c1ccccc1,,ClCCl,,,,val
US04678855,NS(=O)(=O)c1ccc(S(=O)(=O)CCCO)c([N+](=O)[O-])c1>>Nc1cc(S(N)(=O)=O)ccc1S(=O)(=O)CCCO,[Fe],CCO,O,Cl,,val
US20090181928A1,C[Si](C)(C)CCN1C(=O)CN(c2ccc(OCCc3ccccc3)cc2OCc2ccccc2)S1(=O)=O>>O=C1CN(c2ccc(OCCc3ccccc3)cc2OCc2ccccc2)S(=O)(=O)N1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110301161A1,CC(C)(C)n1c(-c2ccccc2C#N)nc2cc(Br)ccc21.OO>>CC(C)(C)n1c(-c2ccccc2C(N)=O)nc2cc(Br)ccc21,,CO,,[NH4+].[OH-],,val
US05681838,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C=Cc1ccc(C(=N)N)cc1>>COC(=O)C=Cc1ccc(C(=N)NC(=O)OC(C)(C)C)cc1,,ClCCl,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20120232051A1,CNc1cnc(Cl)cc1I.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(Cl)cc1I,,C1CCOC1,CCOC(C)=O,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20120071461A1,CN(C)C=C1CN(C(=O)OC(C)(C)C)CCC1=O.CSC(=N)N>>CSc1ncc2c(n1)CCN(C(=O)OC(C)(C)C)C2,,O,,O=S(=O)(O)O,[Na+].[OH-],val
US20140213586A1,COc1cccc(N)c1.O=C(c1csc2ccccc12)C(Br)c1ccccc1>>COc1cccc(NC(C(=O)c2csc3ccccc23)c2ccccc2)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20100226875A1,NOC(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccccc1>>C(=NOC(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccccc1,,CCO,,,,val
US20130190249A1,N#Cc1ccnc(N2C(=O)CC[C@H]2C(=O)N(c2cc(C(N)=O)cc(C(N)=O)c2)C(C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)c1>>N#Cc1cc(C#N)cc(N(C(=O)[C@@H]2CCC(=O)N2c2cc(C#N)ccn2)C(C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)c1,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US20120214987A1,C[C@]12CC[C@H]3O[C@H]3C1=CC(=O)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CCC21OCCO1>>C[C@]12CC[C@@H](O)CC1=CC(=O)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CCC21OCCO1,[Pd],CCOC(C)=O,,CCO,O=C([O-])[O-].[K+].[K+],val
US20090099190A1,CNc1cc(Cl)ncc1CNc1cc([N+](=O)[O-])c(F)cc1C.O=C(Cl)Cl>>Cc1cc(F)c([N+](=O)[O-])cc1N1Cc2cnc(Cl)cc2N(C)C1=O,,C1COCCO1,,CCN(CC)CC,O,val
US20050081313A1,C1COCCN1.O=[N+]([O-])c1cnc(Cl)c([N+](=O)[O-])c1>>O=[N+]([O-])c1cnc(N2CCOCC2)c([N+](=O)[O-])c1,,C1CCOC1,,,,val
US04859692,COC(=O)c1cccc(CBr)c1.O=[N+]([O-])c1ccc2c(c1)NCCO2>>COC(=O)c1cccc(CN2CCOc3ccc([N+](=O)[O-])cc32)c1,,CCC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US05646171,BrCc1ccccc1.CCOC(=O)c1nc(C)[nH]c1C(=O)OCC>>CCOC(=O)c1nc(C)n(Cc2ccccc2)c1C(=O)OCC,,CC(=O)N(C)C,O,CCOC(C)=O,CC(C)(C)[O-].[K+],val
US20110311474A1,COC(=O)c1cnc2c(ccn2S(=O)(=O)c2ccc(C)cc2)n1>>Cc1ccc(S(=O)(=O)n2ccc3nc(C(=O)O)cnc32)cc1,,C1COCCO1,,Cl,,val
US20040014962A1,C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(SC3CN(c4nc(C(=O)N(C)CCNC(=O)OCc5ccc([N+](=O)[O-])cc5)cs4)C3)[C@H](C)[C@H]12>>C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(SC3CN(c4nc(C(=O)N(C)CCN)cs4)C3)[C@H](C)[C@H]12,,C1CCOC1,,,,val
US20090306066A1,C[N+]1([O-])CCOCC1.O=C(OCc1ccccc1)N1CC=CC1.O=[Os](=O)(=O)=O>>O=C(OCc1ccccc1)N1C[C@H](O)[C@H](O)C1,O=[Os](=O)(=O)=O,O,,CC(C)=O,,val
US06294503B1,Cn1c(C(F)(F)F)cc(=O)n(-c2c(F)cc3c(c2N)NC(=O)CO3)c1=O.O=C(Cl)c1ccc2ccccc2c1>>Cn1c(C(F)(F)F)cc(=O)n(-c2c(F)cc3c(c2NC(=O)c2ccc4ccccc4c2)NC(=O)CO3)c1=O,,C1COCCO1,,,,val
US20100105700A1,CC(C)(C)OC(=O)N1C(=O)CC[C@@]2(C)C1=CC[C@H]1[C@@H]3CCC(=O)[C@@]3(C)CC[C@@H]12.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1C(=O)CC[C@@]2(C)C1=CC[C@H]1[C@@H]3CC=C(OS(=O)(=O)C(F)(F)F)[C@@]3(C)CC[C@@H]12,,ClCCl,,CCN(CC)CC,O,val
US20110105509A1,COC(=O)Cn1c(C)c(Cc2ccc(=O)[nH]n2)c2cc(F)ccc21.Fc1ccc(CBr)c(F)c1>>COC(=O)Cn1c(C)c(Cc2ccc(=O)n(Cc3ccc(F)cc3F)n2)c2cc(F)ccc21,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160214997A1,COc1ccc(CNc2nc3c4c(ccc3c3nc(C[C@H](C)OS(C)(=O)=O)nn23)OC(F)(F)O4)c(OC)c1>>C[C@@H](Cc1nc2c3ccc4c(c3nc(N)n2n1)OC(F)(F)O4)OS(C)(=O)=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070060569A1,COc1ccc(B(O)O)cc1.O=S(=O)(O)c1ccc(Br)cc1>>COc1ccc(-c2ccc(S(=O)(=O)O)cc2)cc1,Cl[Pd]Cl,CCOCC,O,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20070259879A1,C[C@@H]1CNCCN1C(=O)c1ccccc1.O=S(=O)(Cl)c1ccc(I)cc1>>C[C@@H]1CN(C(=O)c2ccccc2)CCN1S(=O)(=O)c1ccc(I)cc1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20120208815A1,COC(=O)c1nc(-c2nccs2)ccc1N>>Nc1ccc(-c2nccs2)nc1C(=O)O,,C1CCOC1,,Cl,[Li+].[OH-],val
US20130137720A1,O=C=Nc1cccc2ccccc12.OCc1ccc(CO)cc1>>O=C(Nc1cccc2ccccc12)OCc1ccc(CO)cc1,CN(C)c1ccncc1,CN(C)C=O,,,,val
US20140243373A1,CCN(CC)S(F)(F)F.O=C(OCc1cccc(C(F)(F)F)c1)[C@H]1C[C@@H](O)CN1Cc1cccc(C(F)(F)F)c1>>O=C(OCc1cccc(C(F)(F)F)c1)[C@H]1C[C@H](F)CN1Cc1cccc(C(F)(F)F)c1,,ClCCl,,,,val
US20130210844A1,Nc1ccc(C(F)(F)F)cc1.O=[N+]([O-])c1cccc2c(Cl)nccc12>>O=[N+]([O-])c1cccc2c(Nc3ccc(C(F)(F)F)cc3)nccc12,,CN1CCCC1=O,,,,val
US20070179196A1,CC(=O)OO.CN(C)C(=O)c1ncc(O)c2c1CCN(Cc1ccc(F)c(Cl)c1)C2=O>>CN(C)C(=O)c1c2c(c(O)c[n+]1[O-])C(=O)N(Cc1ccc(F)c(Cl)c1)CC2,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20100168077A1,CC1CCNCC1.COc1ccc(CNc2cc(N3CCN(C)CC3)cc(F)n2)cc1>>CC1CCN(c2cc(N3CCN(C)CC3)cc(N)n2)CC1,,O,,,,val
US20030125317A1,COC(=O)CC(Cc1ccc(OC)cc1CN(CC(F)(F)F)C(=O)OC(C)(C)C)C(=O)OC>>COC(=O)CC(Cc1ccc(OC)cc1CNCC(F)(F)F)C(=O)OC,,ClCCl,,O=C(O)C(F)(F)F,,val
US05124322,COc1ccc(CSc2c(Cl)cccc2C(C)(CC(C)C)C(=O)NC2CCCCCCCCCCNC2=O)cc1>>CC(C)CC(C)(C(=O)NC1CCCCCCCCCCNC1=O)c1cccc(Cl)c1S,,CCCCCC,,,,val
US20070066618A1,CCc1nc2cc(Cl)c(Cl)cc2n1-c1ccc(CC(N)=O)cc1.Cc1ccc(S(=O)(=O)N=C=O)cc1>>CCc1nc2cc(Cl)c(Cl)cc2n1-c1ccc(CC(=O)NC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1,,C1CCOC1,,Cc1ccccc1,,val
US20150239873A1,O=C(CBr)c1ccc(Cl)cc1.O=C(O)CC(CN1CCCC(c2cccc(C(F)(F)F)c2)C1)C(F)(F)F>>O=C(CC(CN1CCCC(c2cccc(C(F)(F)F)c2)C1)C(F)(F)F)OCC(=O)c1ccc(Cl)cc1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US05532235,O=C(Cl)c1ccc([N+](=O)[O-])cc1Cl.c1cnc2c(c1)NCCCC2>>O=C(c1ccc([N+](=O)[O-])cc1Cl)N1CCCCc2ncccc21,,ClCCl,,CCN(CC)CC,O,val
US20060116415A1,CC(=O)Cl.COc1ccc2[nH]c3c(c2c1)COc1ccccc1-3>>COc1ccc2c(c1)c1c(n2C(C)=O)-c2ccccc2OC1,,ClCCl,,CCN(CC)CC,,val
US20120083475A1,CC1(C)OC(=O)C2(CC2)C(=O)O1.Cc1ccccc1N>>Cc1ccccc1N1CCC(C(=O)O)C1=O,,CCO,,,,val
US20120220635A1,CC(C)c1ccc(S)cc1.O=C(O)Cc1ccc(CBr)cc1>>CC(C)c1ccc(SCc2ccc(CC(=O)O)cc2)cc1,,CN(C)C=O,,,,val
US20030105161A1,CC(C)CC(CCCNC(=O)OC(C)(C)C)Nc1cc(C(F)(F)F)ccc1C#N.O=C(O)/C=C/C(=O)O>>CC(C)CC(CCCN)Nc1cc(C(F)(F)F)ccc1C#N.O=C(O)/C=C/C(=O)O,,C1COCCO1,,CCO,Cl,val
US20020007060A1,COC(=O)CBr.Sc1cccs1>>COC(=O)CSc1cccs1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05041455,CC(C)=CCOc1nsnc1-c1cccnc1.CI>>CC(C)=CCOc1nsnc1-c1ccc[n+](C)c1.[I-],,CC(C)=O,,,,val
US07160887B1,CC(C)(C)OC(=O)NCCc1cccc(O)c1.O=[N+]([O-])c1ccc(Cl)cc1F>>CC(C)(C)OC(=O)NCCc1cccc(Oc2cc(Cl)ccc2[N+](=O)[O-])c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20020058837A1,CC[Mg]Br.CN(C)c1ccc(C(=O)c2ccc(N(C)C)cc2)cc1>>CC=C(c1ccc(N(C)C)cc1)c1ccc(N(C)C)cc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20040259910A1,CCOc1cccc(Cc2ncc(C=O)c3cc(O)c(OC)cc23)c1.OCCBr>>CCOc1cccc(Cc2ncc(C=O)c3cc(OCCO)c(OC)cc23)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05684034,COC(=O)CCCCBr.Cc1c(CC(N)=O)c2cc(O)ccc2n1Cc1ccccc1>>COC(=O)CCCCOc1ccc2c(c1)c(CC(N)=O)c(C)n2Cc1ccccc1,,CS(C)=O,,[H-].[Na+],,val
US05231102,COC(=O)[C@H]1C[C@H](NC(=O)c2cccc(CNC(=O)OC(C)(C)C)c2)c2c(Cl)cc(Cl)cc2N1>>CC(C)(C)OC(=O)NCc1cccc(C(=O)N[C@H]2C[C@H](C(=O)O)Nc3cc(Cl)cc(Cl)c32)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20040209943A1,Cc1sc(N)c(C#N)c1C.O=C(Cl)C(c1ccccc1)c1ccccc1>>Cc1sc(NC(=O)C(c2ccccc2)c2ccccc2)c(C#N)c1C,,ClCCl,,CCN(CC)CC,,val
US06197826B1,CC(C)(C)NO.O=Cc1cc(Cl)ccc1O>>CC(C)(C)[N+]([O-])=Cc1cc(Cl)ccc1O,Cl,CO,,,,val
US20100240653A1,CC(C)C(=O)OCCS(=O)(=O)c1ccc(Br)cc1.C[C@@H]1CCCN1CCc1ccc(B(O)O)cc1>>C=CS(=O)(=O)c1ccc(-c2ccc(CCN3CCC[C@H]3C)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,c1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20050233988A1,CCc1ccc(CBr)cc1.O=c1ccc(Br)c[nH]1>>CCc1ccc(Cn2cc(Br)ccc2=O)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20080312226A1,Clc1cccc(-c2csc(N3CCNCC3)n2)c1.O=C(Nc1cccnc1)OCC(Cl)(Cl)Cl>>O=C(Nc1cccnc1)N1CCN(c2nc(-c3cccc(Cl)c3)cs2)CC1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US20120309752A1,C=Cc1c(F)cccc1F.O=C(CCl)C(Cl)=NO>>O=C(CCl)C1=NOC(c2c(F)cccc2F)C1,,CC#N,,O=C([O-])O.[Na+],,val
US20020156081A1,COc1cc(-c2nn(C3CCN(C(=O)OCc4ccccc4)CC3)c3ncnc(N)c23)ccc1NC(=O)OC(C)(C)C>>COc1cc(-c2nn(C3CCN(C(=O)OCc4ccccc4)CC3)c3ncnc(N)c23)ccc1N,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140296252A1,CI.Cc1nc(-n2nc(C(C)(C)C)[nH]c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1>>Cc1nc(-n2nc(C(C)(C)C)n(C)c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160009683A1,CCOC(=O)C(F)(F)Br.FC(F)(F)COc1ccccc1I>>CCOC(=O)C(F)(F)c1ccccc1OCC(F)(F)F,[Cu],CS(C)=O,,O=C([O-])O.[Na+],,val
US05827856,ClC1c2ccccc2CCc2ccccc21.NC(N)=S>>SC1c2ccccc2CCc2ccccc21,,CCO,,O=S(=O)(O)O,[Na+].[OH-],val
US20060094733A1,Cn1c(=O)c2[nH]c(C3CCCC3)nc2n(C)c1=O.Fc1cccc(Cl)c1CBr>>Cn1c(=O)c2c(nc(C3CCCC3)n2Cc2c(F)cccc2Cl)n(C)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06225316B1,BrBr.CCOC(=O)c1ccnc(N2CCN(C)CC2)c1>>CCOC(=O)c1cc(N2CCN(C)CC2)ncc1Br,,ClCCl,O,O=C([O-])O.[Na+],,val
US20080194535A1,C=CCOCCC(NC(=O)C(F)(F)F)c1cccc(OC)c1>>C=CCOCCC(N)c1cccc(OC)c1,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US20030225266A1,CC(CNS(=O)(=O)C(C)C)Oc1ccc(Br)cc1.Cc1cccc(B(O)O)c1>>Cc1cccc(-c2ccc(OC(C)CNS(=O)(=O)C(C)C)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20140343093A1,CCOC(=O)C(=O)CC(C)=O.NNc1ccc(Br)cc1C(=O)O>>CCOC(=O)c1cc(C)n(-c2ccc(Br)cc2C(=O)O)n1,,CC(=O)O,,Cl,,val
US20120277224A1,CCOC(=O)CC(=O)c1cccnc1.Cc1n[nH]c(N)c1-c1ccc(F)cc1>>Cc1nn2c(=O)cc(-c3cccnc3)[nH]c2c1-c1ccc(F)cc1,,CC(=O)O,,,,val
US20130053308A1,Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.Nc1nc(-n2cccn2)nc(-n2cccn2)c1Br>>Cn1cc(-c2c(N)nc(-n3cccn3)nc2-n2cccn2)cn1,,C1COCCO1,O,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20050272744A1,CN(C)C=O.COC1(Cc2ccccc2F)CCN(c2ccc(C(=O)O)cc2)CC1>>COC1(Cc2ccccc2F)CCN(c2ccc(C(N)=O)cc2)CC1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US04835288,COC(=O)C=C(CC(=O)OC)NCCO.CS(=O)(=O)Cl>>COC(=O)C=C(CC(=O)OC)NCCS(C)(=O)=O,,O,,CCN(CC)CC,,val
US20030105110A1,CC1(C)Cc2cccc(O)c2O1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC1(C)Cc2cccc(OS(=O)(=O)C(F)(F)F)c2O1,,ClCCl,,c1ccncc1,,val
US20140011845A1,CCOC(=O)OC1=C(c2cc(C)ccc2C)C(=O)NC1CC1CCSCC1.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)OC1=C(c2cc(C)ccc2C)C(=O)NC1CC1CCS(=O)CC1,,ClCCl,,,,val
US20060148858A1,BrCc1ccccc1.COC(=O)c1cc(O)nn1C>>COC(=O)c1cc(OCc2ccccc2)nn1C,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20030055265A1,CCOC(=O)C(Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)c2ccsc12)N/C(C)=C\C(=O)c1ccccc1>>C/C(=C/C(=O)c1ccccc1)NC(Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)c2ccsc12)C(=O)O,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20150376192A1,COc1ccc(CNN)cc1.O=Cc1c(Cl)cc(Cl)nc1Cl>>COc1ccc(Cn2ncc3c(Cl)nc(Cl)cc32)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20080076745A1,CC(C)(C)OC(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)NCCNC(=O)OCc1ccccc1.Cl>>Cl.N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)NCCNC(=O)OCc1ccccc1,,C1COCCO1,,,,val
US20100121048A1,COC(=O)c1ncn(C2CCCN(C(=O)OCc3ccccc3)C2)c1-c1ccccc1>>O=C(O)c1ncn(C2CCCN(C(=O)OCc3ccccc3)C2)c1-c1ccccc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20110046108A1,CS(=O)(=O)Cl.CS(=O)(=O)c1cc(N)cc(N)c1>>CS(=O)(=O)Nc1cc(N)cc(S(C)(=O)=O)c1,,ClCCl,,c1ccncc1,,val
US20060049397A1,CC(=O)N(c1ccc(C(C)C)cc1)c1ccc(C(C)C)cc1>>CC(C)c1ccc(Nc2ccc(C(C)C)cc2)cc1,,CCO,,,,val
US20150057392A1,C=C(CC)CC/C=C(\C)CCC=C(C)C.C=Cc1ccccc1>>C=C(CC)CC/C=C(\C)CCC=C(C)C.C=Cc1ccccc1,,CO,,,,val
US20110160243A1,CC(C)(C)OC(=O)N1CCCC1=O.CCOC(=O)CBr>>CCOC(=O)CC1CCN(C(=O)OC(C)(C)C)C1=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US03931218,Cc1ccc(S(=O)(=O)NCCNC(C)C)cc1.O=C(O)c1ccccc1C(=O)c1ccccc1>>Cc1ccc(S(=O)(=O)NCCN(C(=O)c2ccccc2C(=O)c2ccccc2)C(C)C)cc1,,CCN(CC)CC,,ClCCl,,val
US20040122244A1,C1COCCN1.COC1=C(OC)C(=O)C(Cc2ccc(C(=O)O)c(OCc3ccccc3)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(C(=O)N3CCOCC3)c(OCc3ccccc3)c2)=C(C)C1=O,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20070123492A1,CCCCCCCC/C=C\CCCCCCCC(=O)C[C@@H](CC(F)(F)P(=O)([O-])[O-])C(=O)CCCCCCC/C=C\CCCCCCCC.[Na+].[Na+]>>CCCCCCCC/C=C\CCCCCCCC(=O)C[C@H](CC(F)(F)P(=O)([O-])[O-])C(=O)CCCCCCC/C=C\CCCCCCCC.[Na+].[Na+],,CO,,,,val
US05118672,[N-]=[N+]=N[C@H]1C[C@H](n2ccc(=O)[nH]c2=O)O[C@@H]1COC(c1ccccc1)(c1ccccc1)c1ccccc1>>[N-]=[N+]=N[C@H]1C[C@H](n2ccc(=O)[nH]c2=O)O[C@@H]1CO,,CC(=O)O,,,,val
US20120245137A1,NC1CCCCC1.O=C(CCl)N1CCC(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1>>O=C(CNC1CCCCC1)N1CCC(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1,,CC#N,,,,val
US04311696,CC(C)C(C(=O)O)c1ccc([N+](=O)[O-])cc1.OCc1ccccc1>>CC(C)C(C(=O)OCc1ccccc1)c1ccc([N+](=O)[O-])cc1,,O,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US20140243302A1,CC1(C)OC(=O)CC(=O)O1.CCOC(OCC)OCC.COc1cc(C)c(N)cn1>>COc1cc(C)c(NC=C2C(=O)OC(C)(C)OC2=O)cn1,,CCO,,,,val
US20150232480A1,C=CC[C@@H](C)O.Oc1cc(F)c(F)cc1Br>>C=CC[C@H](C)Oc1cc(F)c(F)cc1Br,,C1CCOC1,CCOCC,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05123951,CCOC(=O)C1(C(=O)Cl)CCCC1.Cc1cc(Br)ccc1N>>CCOC(=O)C1(C(=O)Nc2ccc(Br)cc2C)CCCC1,,C1CCOC1,,CCN(CC)CC,,val
US05439917,COc1ccccc1C(=O)CBr.Cc1[nH]c2ncc(F)cc2c1CC#N>>Br.COc1ccccc1C(=O)Cn1cc(F)cc2c(CC#N)c(C)nc1-2,,CC#N,CCOCC,,,val
US20100105655A1,COc1cc(N2CCN(C(=O)OC(C)(C)C)CC2=O)ccc1[N+](=O)[O-]>>COc1cc(N2CCN(C(=O)OC(C)(C)C)CC2=O)ccc1N,O=[Pt]=O,CCO,,,,val
US20040266774A1,Cc1ncn(-c2cccc(N)c2)c1C.O=C(O)c1cccc2c1[nH]c1ccc(F)cc12>>Cc1ncn(-c2cccc(NC(=O)c3cccc4c3[nH]c3ccc(F)cc34)c2)c1C,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20090018133A1,CC(C)(C)OC(=O)N(CCO)CCN(C(=O)OC(C)(C)C)c1ccc(NC(=O)CC23CC4CC(CC(C4)C2)C3)c2cccnc12>>O=C(CC12CC3CC(CC(C3)C1)C2)Nc1ccc(NCCNCCO)c2ncccc12,,C1COCCO1,ClC(Cl)Cl,Cl,,val
US20050054662A1,COCCBr.Oc1cc(OC2CCOCC2)c2c(N(F)c3cccc(Cl)c3)ncnc2c1>>COCCOc1cc(OC2CCOCC2)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1,,CN(C)C=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20140243310A1,CCCCC(CC)COC(=O)CCSc1cc(OC[C@H](C)NC(C)=O)ncc1[N+](=O)[O-]>>CCCCC(CC)COC(=O)CCSc1cc(OC[C@H](C)NC(C)=O)ncc1N,,O,,CCO,[Cl-].[NH4+],val
US20140288128A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)CCN>>CC(C)CCNC(=O)OC(C)(C)C,,CO,ClCCl,CCN(CC)CC,,val
US20150148349A1,O=C(OCc1ccccc1)c1c[nH]c2ccccc12.O=C=NS(=O)(=O)Cl>>NC(=O)n1cc(C(=O)OCc2ccccc2)c2ccccc21,,C1CCOC1,O,CC(=O)O,[H-].[Na+],val
US20100063098A1,COC(=O)c1ccc(=O)n(-c2c(Cl)cccc2Cl)c1.Nc1cc(C(=O)O)ccc1Cl>>O=C(O)c1ccc(Cl)c(NC(=O)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2)c1,,C1CCOC1,,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20120040991A1,CC(C)(C)OC(=O)N1C[C@H]2C[C@H]2C[C@H]1COc1cc(Cl)ccn1>>Clc1ccnc(OC[C@@H]2C[C@@H]3C[C@@H]3CN2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04183951,CCOC(=O)CC(=O)Nc1cc(OC)c(OC)c(OC)c1.CO.NO>>COc1cc(O)cc(OC)c1OC.NC(=O)CC(=O)NO,,CO,,Cl,[Na],val
US03959260,C1CCNCC1.O=C(O)CCl>>O=C(O)CN1CCCCC1,,O,,[Na+].[OH-],,val
US05589474,O=C1NC2=C(C=CCC2)Sc2cc(C(F)(F)F)ccc21.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>FC(F)(F)c1ccc2c(c1)Sc1ccccc1NC2=S,,c1ccncc1,,O,,val
US04254135,O=C(N[C@@H]1CN(Cc2ccccc2)C[C@H]1O)c1ccccc1>>O=C(N[C@@H]1CNC[C@H]1O)c1ccccc1,[Pd],,,,,val
US20110003737A1,Cc1ccc(S(=O)(=O)n2c3c(c4ccc(-n5ccc(OCc6ccccc6)cc5=O)cc42)C2CCC(C3)N2)cc1.ClCCl>>Cl.O=c1cc(OCc2ccccc2)ccn1-c1ccc2c3c([nH]c2c1)CC1CCC3N1,,O,,CO,[Na+].[OH-],val
US20040077653A1,CCCC(CC(=O)O)C(C)=O.NN>>CCCC1CC(=O)NN=C1C,,CCO,,O,,val
US20080234255A1,CCOC(=O)CC(C)N(c1nc(Cl)ncc1[N+](=O)[O-])C1CCCC1>>CC1CN(C2CCCC2)c2nc(Cl)ncc2NC1=O,[Fe],,,CC(=O)O,,val
US20120114600A1,CC(C)(C)OC(=O)N1CCC[C@H]1c1nc(-c2ccc(Br)cc2)c[nH]1>>Brc1ccc(-c2c[nH]c([C@@H]3CCCN3)n2)cc1,,CO,,Cl,,val
US20130005730A1,C=O.COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)ccc1OC>>COCCCOc1cc(C[C@@H](C[C@@H]2NCO[C@H]2C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)ccc1OC,,C1CCOC1,,ClCCl,O,val
US05175288,O=C(O)C1(C(=O)O)CC1.O=C1CCCCC1>>O=C1OC2(CCCCC2)OC(=O)C12CC2,O=S(=O)(O)O,,,CC(=O)OC(C)=O,,val
US20090042852A1,CCOC(=O)c1ncoc1CC>>CCc1ocnc1C(=O)O,,CCO,O,[Na+].[OH-],,val
US20020002158A1,CC(CNS(C)(=O)=O)c1ccc(Br)cc1.OB(O)c1cccc(F)c1>>CC(CNS(C)(=O)=O)c1ccc(-c2cccc(F)c2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US20130252941A1,COc1c[n+]([O-])cc2cn(-c3c(Cl)cccc3Cl)nc12.O=P(Br)(Br)Br>>COc1cnc(Br)c2cn(-c3c(Cl)cccc3Cl)nc12,,ClCCCl,,,,val
US20130317166A1,C=CC.CO.COc1c(C)c2c(c(O[C@@H]3O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]3O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2>>C=CC.C=CCCCCCCCCCCCC,,CO,,[H][H],,val
US20080064699A1,COCCBr.N#Cc1cnc(NC(=O)C23CC4CC(CC(C4)C2)C3)s1>>COCCn1cc(C#N)s/c1=N\C(=O)C12CC3CC(CC(C3)C1)C2,,C1CCOC1,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US20080161294A1,C[C@@H](N)CO.O=Cc1ccccc1NS(=O)(=O)c1ccccc1[N+](=O)[O-]>>C[C@H](CO)N=Cc1ccccc1NS(=O)(=O)c1ccccc1[N+](=O)[O-],,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20120214767A1,C1COCCN1.C=Cc1ccc2c(c1)OCCC2=O>>C=Cc1ccc2c(c1)OCC=C2N1CCOCC1,Cl[Ti](Cl)(Cl)Cl,Cc1ccccc1,,,,val
US20060135773A1,CCOP(=O)(OCC)C(F)(F)c1ccc(CN(Cc2ccccc2)S(=O)(=O)c2ccccc2C(N)=O)cc1Cl>>NC(=O)c1ccccc1S(=O)(=O)N(Cc1ccccc1)Cc1ccc(C(F)(F)P(=O)(O)O)c(Cl)c1,,ClCCl,,C[Si](C)(C)I,,val
US04734419,NCc1ccc(Cl)c(Cl)c1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>O=[N+]([O-])c1ccccc1S(=O)(=O)NCc1ccc(Cl)c(Cl)c1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20130336920A1,CC(C)(C)OC(=O)CCSCc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(NCc3cccc(C(F)(F)F)c3)ncn2)c1>>O=C(O)CCSCc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(NCc3cccc(C(F)(F)F)c3)ncn2)c1,,CC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20030125370A1,Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CC(=O)O.O[C@H]1CN[C@H](CNC2CC2)C1>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CC(=O)N1C[C@H](O)C[C@H]1CNC1CC1,,CN(C)C=O,ClCCl,ClCCCl,On1nnc2ccccc21,val
US20090247526A1,CC(=O)CCl.NC(=S)Nc1cc(Oc2cccc3ncccc23)c(Br)cn1>>Cc1csc(Nc2cc(Oc3cccc4ncccc34)c(Br)cn2)n1,,CCO,,CCN(CC)CC,,val
US20050026964A1,C#Cc1ccc(Nc2cc(=O)[nH]cc2C(=O)NCCCO)c(F)c1>>CCc1ccc(Nc2cc(=O)[nH]cc2C(=O)NCCCO)c(F)c1,[Pd],C1CCOC1,CO,,,val
US05082838,O=c1c(-c2ccccc2)c2n(c(=O)n1Cc1ccccc1)C=CCS2=O>>O=c1c(-c2ccccc2)c2n(c(=O)n1Cc1ccccc1)C=CCS2,,CN(C)C=O,,ClP(Cl)Cl,,val
US20040053908A1,CC(C)(C)OC(=O)N1CCC(COc2cc3nccc(Oc4ccc(N)c(F)c4)c3cc2C#N)CC1.O=C(Cl)Oc1ccccc1>>CC(C)(C)OC(=O)N1CCC(COc2cc3nccc(Oc4ccc(NC(=O)Oc5ccccc5)c(F)c4)c3cc2C#N)CC1,,C1CCOC1,,c1ccncc1,,val
US20120129806A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(O)C1Cc2ccc(Cl)cc2CN1>>CC(C)(C)OC(=O)N1Cc2cc(Cl)ccc2CC1C(=O)O,,C1COCCO1,,Cl,[Na+].[OH-],val
US06329400B1,CCC[C@@H](O)[C@@H](C/C=C/c1ccccc1)C(=O)OCC>>CCC[C@@H](O)[C@@H](CCCc1ccccc1)C(=O)OCC,[Pd],CCOC(C)=O,,,,val
US20050004363A1,NC(=O)CBr.Nc1cccc(F)c1>>NC(=O)CNc1cccc(F)c1,,CCO,,,,val
US20130197045A1,CS(=O)(=O)Cl.Cc1cc2c(cc1CO)COC2>>Cc1cc2c(cc1CCl)COC2,,O,,CCN(CC)CC,ClCCl,val
US04820729,CC(=O)C(=O)O.CCO.C[C@H](NC(=O)OCc1ccccc1)C(=O)N(CC(=O)O)Cc1ccccc1>>CC(=O)C(=O)O.CC(N[C@@H](C)C(=O)N(CC(=O)O)Cc1ccccc1)C(=O)O,[Pd],CCO,,,,val
US20020156296A1,CCC1(CC)Cc2c(cc(C(C)C)c(OC(C)=O)c2C(C)C)O1>>CCC1(CC)Cc2c(cc(C(C)C)c(O)c2C(C)C)O1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110021522A1,Nc1cccc(-c2ccc3c(c2)OCCO3)c1.O=C(O)c1cc2cccc(O)c2oc1=O>>O=C(Nc1cccc(-c2ccc3c(c2)OCCO3)c1)c1cc2cccc(O)c2oc1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050258396A1,CI.COc1ccc2ccsc2c1>>COc1ccc2cc(C)sc2c1,,C1CCOC1,CCCCCC,O,[Li]CCCC,val
US20100004245A1,CC1(C)OB(c2ccc(N3CCC(Oc4ccccc4C(F)(F)F)CC3)nc2)OC1(C)C.CCOC(=O)c1cncc(Br)c1>>CCOC(=O)c1cncc(-c2ccc(N3CCC(Oc4ccccc4C(F)(F)F)CC3)nc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20020147214A1,c1ccc(Cn2ncc3cc(Nc4ncnc5cc(-c6ccc(C7OCCO7)o6)ccc45)ccc32)cc1>>O=Cc1ccc(-c2ccc3c(Nc4ccc5c(cnn5Cc5ccccc5)c4)ncnc3c2)o1,,C1CCOC1,,Cl,Cl,val
US04243668,COc1cccc2cc(CCN)oc12.O=C(Cl)C1CC1>>COc1cccc2cc(CCNCC3CC3)oc12,,ClCCl,,[Na+].[OH-],,val
US20090298807A1,CC(C)(C)[Si](C)(C)OCCc1cccs1.CN(C)C=O>>CC(C)(C)[Si](C)(C)OCCc1ccc(C=O)s1,,C1CCOC1,,[Li]CCCC,,val
US20060135554A1,C1CCNC1.CCOc1ccc(Cc2nc3cc(C(=O)O)ccc3n2CC2CC2)nc1>>CCOc1ccc(Cc2nc3cc(C(=O)N4CCCC4)ccc3n2CC2CC2)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160221972A1,CC(C)[C@H](N)CO.COC(=O)c1ccc(CBr)c(Br)c1>>COC(=O)c1ccc(CN[C@H](CO)C(C)C)c(Br)c1,,CC#N,,,,val
US05981533,CC(=O)OC(C)=O.N#Cc1c(NCc2ccc(N)cc2)n[nH]c1N>>CC(=O)Nc1ccc(CNc2n[nH]c(N)c2C#N)cc1,,C1CCOC1,,,,val
US20130331372A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)CCc1ccc(F)c(I)c1>>COC(=O)CCc1ccc(F)c(B2OC(C)(C)C(C)(C)O2)c1,,C1COCCO1,CS(C)=O,CC(=O)[O-].[K+],,val
US20120058984A1,CC(C)(C)CC(C)(C)N.COCc1cc(OS(=O)(=O)C(F)(F)F)nc(SC)n1>>COCc1cc(N)nc(SC)n1,,CC#N,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20150210687A1,Clc1cccc(Br)c1COC1CCCCO1.O=C1CCC1>>OC1(c2cccc(Cl)c2COC2CCCCO2)CCC1,,C1CCOC1,,O,[Li]CCCC,val
US06114361,C[Si](C)(C)CCONC(=O)[C@H]1C[C@@H](c2ccc(OCc3ccccc3)cc2)C(=O)N1>>O=C(NO)[C@H]1C[C@@H](c2ccc(OCc3ccccc3)cc2)C(=O)N1,,ClCCl,,CCOCC,FB(F)F,val
US20140107094A1,CC1(C)OC(=O)C(Cc2ccc(-n3cccn3)cc2)C(=O)O1>>O=C(O)C(Cc1ccc(-n2cccn2)cc1)C(=O)O,,O,,[Na+].[OH-],,val
US20030134859A1,CCCCCCCC=O.Nc1ccc(-c2ccc(NC(=O)c3cc([N+](=O)[O-])ccc3Cl)cc2)cc1>>CCCCCCCCNc1ccc(-c2ccc(NC(=O)c3cc([N+](=O)[O-])ccc3Cl)cc2)cc1,,CO,,[BH3-]C#N.[Na+],,val
US06500946B1,O=S(=O)(Cl)Cl.O[C@@H]1C[C@@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)O[C@H]1n1cnc2c(Cl)ncnc21.c1c[nH]cn1>>O=S(=O)=C1C=NC(O[C@@H]2C[C@@H](COC(c3ccccc3)(c3ccccc3)c3ccccc3)O[C@H]2n2cnc3c(Cl)ncnc32)=N1,,ClCCl,,O,,val
US20110112080A1,CC(C)(C)OC(=O)N1[C@@H](CCc2ccc(N)cc2)COC1(C)C.O=S(=O)(Cl)c1cccc2cnccc12>>CC(C)(C)OC(=O)N1[C@@H](CCc2ccc(NS(=O)(=O)c3cccc4cnccc34)cc2)COC1(C)C,,C1CCOC1,CCN(CC)CC,,,val
US20100267722A1,Cc1cc(N2C[C@H](S(=O)(=O)c3ccc(F)cc3C(F)(F)F)C[C@H]2C(=O)NC2(C#N)CC2)n(C2CCC2)n1.OCC(F)(F)F>>Cc1cc(N2C[C@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3C(F)(F)F)C[C@@H]2C(=O)NC2(C#N)CC2)n(C2CCC2)n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130343992A1,FCCn1cc(-c2ccncc2)c(-c2ccc(OCc3ccccc3)cc2)n1>>Oc1ccc(-c2nn(CCF)cc2-c2ccncc2)cc1,[Pd],CCO,CCOC(C)=O,,,val
US20110065681A1,COC(=O)c1cc(OCC2COC(C)(C)O2)cc(-c2ccc(C)cc2C#N)c1>>Cc1ccc(-c2cc(OCC3COC(C)(C)O3)cc(C(=O)O)c2)c(C#N)c1,,C1CCOC1,,Cl,[Li+].[OH-],val
US05041610,C[C@H](O)CCC[C@H](O)CCCCCc1cc(OCc2ccccc2)cc(OCc2ccccc2)c1C(=O)O>>C[C@H](O)CCC[C@H](O)CCCCCc1cc(O)cc(O)c1C(=O)O,[Pd],CCO,,[H][H],,val
US05089493,CI.Cc1nc(Cl)c2c(n1)NC(=O)CO2>>Cc1nc(Cl)c2c(n1)N(C)C(=O)CO2,,CO,,C[O-].[Na+],,val
US20140107335A1,N#CC(c1cnc(C(F)F)nc1)N1CCOCC1>>NCC(c1cnc(C(F)F)nc1)N1CCOCC1,[Ni],CO,,N,O,val
US06306895B1,COCCOCOC(CCCCC=O)COc1ccc(F)cc1>>O=CCCCCC(O)COc1ccc(F)cc1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20090082372A1,CCOC(=O)C(N)Cc1n[nH]c2c(C(F)(F)F)cccc12>>NC(CO)Cc1n[nH]c2c(C(F)(F)F)cccc12,,C1CCOC1,CCO,[BH4-].[Li+],,val
US20110237791A1,CCOC(=O)c1ccc(C(F)(F)F)c(OC)n1>>COc1nc(CO)ccc1C(F)(F)F,,CO,,O,[BH4-].[Na+],val
US06365753B1,O=C1c2ccccc2C(=O)N1c1ccc(Cl)cc1F.O=[N+]([O-])O>>O=C1c2ccccc2C(=O)N1c1cc([N+](=O)[O-])c(Cl)cc1F,,O=S(=O)(O)O,,,,val
US04582839,CCc1ccc(C(COc2ccc(CC(Br)C(=O)OC)cc2)OC(C)=O)nc1.NC(N)=S>>CCc1ccc(C(O)COc2ccc(CC3SC(=O)NC3=O)cc2)nc1,,CCO,,CC(=O)[O-].[Na+],,val
US04335142,O=S(=O)(c1ccc(Cl)cc1)C(CCl)Sc1ccccc1>>C=C(Sc1ccccc1)S(=O)(=O)c1ccc(Cl)cc1,,C1CCOC1,,CCN(CC)CC,,val
US05753654,CCOC(=O)CC#N.CI.S=C=NC1CCCCC1>>CCOC(=O)C(C#N)=C(NC1CCCCC1)SC,,CN(C)C=O,O,[H-].[Na+],,val
US20120059028A1,COc1ccc(Br)c2[nH]c(=O)cc(CCO)c12>>O=c1cc(CCO)c2c(O)ccc(Br)c2[nH]1,,O,,BrB(Br)Br,,val
US20050070534A1,CC(=O)N1CCc2ccc(NC3CCN(Cc4ccccc4)CC3)cc21.O=C(O)C#Cc1ccccc1>>CC(=O)N1CCc2ccc(N(C(=O)C#Cc3ccccc3)C3CCN(Cc4ccccc4)CC3)cc21,,Cc1ccccc1,,O=S(Cl)Cl,,val
US05338755,N#Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc(Cl)cc1C(=O)c1ccccc1Cl>>N#Cc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccccc2Cl)cc1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20060025601A1,CC1c2cc(Cl)c(O)cc2C2CNCC12.CCNC(=O)[O-].Fc1ccc(CBr)cc1>>CC1c2cc(Cl)c(OCc3ccc(F)cc3)cc2C2CNCC12.CCNC(=O)[O-],,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160108027A1,CCOC(=O)CC1CCC(C)CN1C(=O)OC(C)(C)C.CC[Mg]Br>>CC1CCC(CC2(O)CC2)N(C(=O)OC(C)(C)C)C1,,CCOCC,,O=S(=O)(O)O,,val
US20110227049A1,Brc1ccnc(-c2ccccc2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC1(C)OB(c2ccc(-c3ccccc3)nc2)OC1(C)C,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20130150344A1,COc1cnnc(-c2ccnn2-c2ccccc2)c1O.Fc1ccccn1>>COc1cn(-c2ccccn2)nc(-c2ccnn2-c2ccccc2)c1=O,,CN1CCCC1=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US04767779,Clc1ccc(C2=C(c3ccccc3)CNN2)cc1.Nc1ccc(Oc2ccc(Cl)cc2)cc1.O=C(Cl)OC(Cl)(Cl)Cl>>O=C(Nc1ccc(Oc2ccc(Cl)cc2)cc1)N1CC(c2ccccc2)=C(c2ccc(Cl)cc2)N1,CCN(CC)CC,CCOCC,Cc1ccccc1,,,val
US06300342B1,N#Cc1ccc(CCC(=O)N2CCCc3cc(N)ccc32)cc1.O=Cc1ccccc1>>N#Cc1ccc(CCC(=O)N2CCCc3cc(NCc4ccccc4)ccc32)cc1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20100305085A1,CCO.Cc1cn(CC(=O)O)nn1>>CCOC(=O)Cn1cc(C)nn1,O=S(=O)(O)O,,,,,val
US20090192325A1,CCCC(=O)OC(CCC)OC(C)=S>>CCCC(=O)O[C@H](CCC)OC(C)=S,,O,,COC(C)(C)C,,val
US05409956,CCOC(=O)Cc1ccc2c(c1)CC(CNS(=O)(=O)c1ccccc1)C2>>O=C(O)Cc1ccc2c(c1)CC(CNS(=O)(=O)c1ccccc1)C2,,CO,,[Na+].[OH-],,val
US04952573,CCOC(=O)C1CCN(C(=O)OCC)c2ccccc2C1O>>CCOC(=O)C1=Cc2ccccc2N(C(=O)OCC)CC1,,C1CCOC1,,O=S(=O)(O)O,,val
US06498172B1,COC(=O)CCc1cccc(CNCc2ccc(-c3ncccn3)cc2)c1.O=S(=O)(Cl)c1ccccc1>>COC(=O)CCc1cccc(CN(Cc2ccc(-c3ncccn3)cc2)S(=O)(=O)c2ccccc2)c1,,CCN(CC)CC,,,,val
US20140323435A1,COc1ccccc1C[C@H](NC(=O)OC(C)(C)C)C(N)=O>>COc1ccccc1C[C@@H](CN)NC(=O)OC(C)(C)C,,CC(=O)O,CO,C1CCOC1,,val
US20150232481A1,Brc1ccccc1CCI.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Brc1ccccc1CC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[I-],,Cc1ccccc1,,,,val
US20050245572A1,O=C(CBr)c1ccccc1.O=C(CC(=O)OCc1ccccc1)OCc1ccccc1>>O=C(OCc1ccccc1)c1c(O)cc(O)c2ccccc12,,C1COCCO1,CCOC(C)=O,Cl,[H-].[Na+],val
US20090291960A1,Nc1cccnn1.O=C(CBr)OC(=O)CBr>>O=C(CBr)Nc1cccnn1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090143353A1,COc1c(F)c(-c2cccc(OCc3ccccc3)c2)c(C)c(C#N)c1NC(=O)C(F)(F)F>>COc1c(N)c(C#N)c(C)c(-c2cccc(OCc3ccccc3)c2)c1F,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20130102600A1,CC(C)(C)ONC(=O)c1cc(Br)ccn1.NCc1ccccc1>>CC(C)(C)ONC(=O)c1cc(NCc2ccccc2)ccn1,,CCO,,,,val
US20070027143A1,C=C1CC(=O)O1.CC1Cc2cc3c(cc2C(c2ccc([N+](=O)[O-])cc2)=NN1)OCO3>>CC(=O)CC(=O)N1N=C(c2ccc([N+](=O)[O-])cc2)c2cc3c(cc2CC1C)OCO3,,Cc1ccccc1,,,,val
US20140030221A1,CI.C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)O>>COC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04828979,O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C1CCC(=O)N1O>>O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C1CCC(=O)N1O,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20140249131A1,CCOC(C)=O.CSc1ncc(C(C)=O)c(Nc2cccc(NC(=O)OC(C)(C)C)c2)n1>>CSc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)OC(C)(C)C)c3)c2n1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20070066624A1,CC(C)NC(=O)c1cc(C=O)ccc1O.O=C1N(C2CCOCC2)C[C@@H](c2ccccc2)N1C1CCNCC1>>CC(C)NC(=O)c1cc(CN2CCC(N3C(=O)N(C4CCOCC4)C[C@H]3c3ccccc3)CC2)ccc1O,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160185764A1,Cc1nc(N)ccc1Br.II>>Cc1nc(I)ccc1Br,[Cu]I,ClCCl,,CC(C)CCON=O,,val
US20030087775A1,CC(C)=O.ClCCC1C=CCC1>>CC(C)(O)CCC1C=CCC1,,C1CCOC1,,Cl,[Mg],val
US20070004730A1,CNC(=N)N.O=C(C(=O)c1ccncc1)c1ccccc1>>CN1C(=O)C(c2ccccc2)(c2ccncc2)N=C1N,,CCO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20060166990A1,COc1cccc(N=C=O)c1.Cc1ccc(N)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl>>COc1cccc(NC(=O)Nc2ccc(C)c(C(=O)c3ccc(Nc4ccc(F)cc4F)cc3Cl)c2)c1,,c1ccncc1,,,,val
US04086238,COCC(C=O)NCCl.O=C=Nc1nnc(CCl)s1>>COCC(C=O)N(CCl)C(=O)Nc1nnc(CCl)s1,,c1ccccc1,,,,val
US04628057,CCOC(=O)[C@@H]1Cc2c([nH]c3ccccc23)CN1.CI.S=C=S>>CCOC(=O)[C@@H]1Cc2c([nH]c3ccccc23)CN1C(=S)SC,,CCO,,CCN(CC)CC,,val
US20130261128A1,COC(=O)C1(COc2cc(C)c(-c3ccc(-c4nc(C(F)(F)F)cn4COCC[Si](C)(C)C)c(Cl)c3)cn2)CC1>>Cc1cc(OCC2(C(=O)O)CC2)ncc1-c1ccc(-c2nc(C(F)(F)F)cn2COCC[Si](C)(C)C)c(Cl)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20060160876A1,CCOC(=O)CC1(CC)OCCc2c1[nH]c1ccccc21>>CCC1(CC(=O)O)OCCc2c1[nH]c1ccccc21,,C1COCCO1,O,Cl,[Li+].[OH-],val
US20100094014A1,CCOC(=O)c1ccc(Cl)cc1O[C@H]1CC[C@H]2CN(C(=O)OC(C)(C)C)[C@H](C(=O)OCC)C[C@H]2C1.Cl>>CCOC(=O)c1ccc(Cl)cc1O[C@H]1CC[C@H]2CN[C@H](C(=O)OCC)C[C@H]2C1.Cl,,CCOC(C)=O,,,,val
US20070219228A1,CCOCc1nc2c(N)nc3cc(Br)cnc3c2n1CC(C)(C)O.OB(O)c1ccc(F)nc1>>CCOCc1nc2c(N)nc3cc(-c4ccc(F)nc4)cnc3c2n1CC(C)(C)O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US04871748,CC(=O)O.CC(C)(CO)c1ccncc1>>CC(=O)O.CC(C)(CO)C1CCNCC1,O=[Pt],,,[H][H],,val
US06420365B1,COc1ccc(Br)cc1Cc1c(CNCCC(C)C)nc2ccccn12>>CC(C)CCNCc1nc2ccccn2c1Cc1cc(Br)ccc1O,,ClCCl,,BrB(Br)Br,,val
US20030158418A1,COC(=N)c1cnccn1.NCC(N)(c1ccc(F)cc1)c1ccc(F)cc1>>Fc1ccc(C2(c3ccc(F)cc3)CNC(c3cnccn3)=N2)cc1,,CO,,,,val
US06893650B1,Cc1cc([N+](=O)[O-])c(C)cc1Br.OB(O)c1cc2ccccc2s1>>Cc1cc([N+](=O)[O-])c(C)cc1-c1cc2ccccc2s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,CCOC(C)=O,O,val
US20150038574A1,CC1=C(CO)C(C)(C)CCC1.N#Cc1ccc(O)cc1F>>CC1=C(COc2ccc(C#N)c(F)c2)C(C)(C)CCC1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100160424A1,CN(C(=O)OC(C)(C)C)[C@@H](CNC(=O)OCc1ccccc1)C[C@H]1CCCOC1>>CN(C(=O)OC(C)(C)C)[C@@H](CN)C[C@H]1CCCOC1,[Pd],CO,,,,val
US20060264460A1,N#Cc1cnc2c(Cl)cc(N)cc2c1Nc1ccc(F)c(Cl)c1.[N-]=[N+]=NCC=O>>N#Cc1cnc2c(Cl)cc(NCCN=[N+]=[N-])cc2c1Nc1ccc(F)c(Cl)c1,,CCO,,[BH3-]C#N.[Na+],,val
US04962234,CC(=O)c1ccc(N=C(C)c2ccccc2)cc1.Nc1ccccc1>>CC(Nc1ccccc1)c1ccc(C(C)Nc2ccccc2)cc1,[Pd],,,CCO,,val
US20130131035A1,Clc1ncnc(Cl)n1.FC(F)(F)Oc1ccc(COC2CCNCC2)cc1>>FC(F)(F)Oc1ccc(COC2CCN(c3ncnc(Cl)n3)CC2)cc1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US05753664,BrC(Br)(Br)Br.CC(O)C1CCN(C(=O)OC(C)(C)C)CC1>>CC(Br)C1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04276417,C=CCN(CC=C)c1nc(N)n2oc(=O)nc2n1.O=C(Cl)OCc1ccccc1>>C=CCN(CC=C)c1nc(NC(=O)OCc2ccccc2)n2oc(=O)nc2n1,,CCN(CC)CC,O,Cl,ClCCl,val
US20080171772A1,CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(O)cc2n1Cc1ccccc1.O=S(=O)(N(c1ccc(Cl)cn1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(OS(=O)(=O)C(F)(F)F)cc2n1Cc1ccccc1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,,,val
US20090012129A1,CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(/C=C(\CC)C(=O)OCC)cc2OCC)c1>>CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(/C=C(\CC)C(=O)O)cc2OCC)c1,,CCO,,[Na+].[OH-],,val
US20040092498A1,CCC(O)CN(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C.Oc1cccc(Cl)c1>>CCC(CN(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)Oc1cccc(Cl)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130059845A1,NN=C(Nc1ccc(Cl)cc1)c1c(-c2cc(Cl)ccc2Cl)nc2ccccn12.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]nc(-c2c(-c3cc(Cl)ccc3Cl)nc3ccccn23)n1-c1ccc(Cl)cc1,,C1CCOC1,,CCOC(C)=O,,val
US20100093730A1,Clc1ccc(CN2CCNCC2)c(Cl)c1.O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O>>O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)N1CCN(Cc2ccc(Cl)cc2Cl)CC1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20140274688A1,CCOC(=O)C1CC1c1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1>>O=C(O)C1CC1c1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1,,CO,,Cl,[Na+].[OH-],val
US20050261496A1,CCOC(=O)c1[nH]c2ccc(Br)cc2c1S(=O)(=O)N1CCOCC1.O=[N+]([O-])O>>CCOC(=O)c1[nH]c2ccc(Br)c([N+](=O)[O-])c2c1S(=O)(=O)N1CCOCC1,,O=S(=O)(O)O,,,,val
US20060004069A1,CCC(=O)Cl.NC(Cc1ccc([N+](=O)[O-])cc1)=NO>>CCc1nc(Cc2ccc([N+](=O)[O-])cc2)no1,,O,,CC(=O)N(C)C,,val
US20050107343A1,CCCCCCCC(=O)Nc1nc(Cl)c2c(CN(Cc3ccccc3)Cc3ccccc3)c[nH]c2n1.COc1c(C)cnc(CCl)c1C>>COc1c(C)cnc(Cn2cc(CN(Cc3ccccc3)Cc3ccccc3)c3c(Cl)nc(N)nc32)c1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050032786A1,COC(=O)c1ccccc1S.N#Cc1ccnc(OCc2ccccc2)c1>>O=c1nc(-c2ccnc(OCc3ccccc3)c2)sc2ccccc12,,Cc1ccccc1,,CCN(CC)CC,,val
US05776964,CC(C)(C)O.O=C(Cl)C(=O)Cl.c1c[nH]cn1>>CC(C)(C)OC(=O)C(=O)n1ccnc1,,C1CCOC1,,,,val
US04656179,C=O.COc1cc2c(cc1OC)C(C(CO)CO)NCC2.Cl>>COc1cc2c(cc1OC)C(C(CO)CO)N(C)CC2.Cl,,O=CO,,,,val
US20080287547A1,CC(C)(C(N)c1ccccc1)N1CCCC1.CSc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)Cl>>CSc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)NC(c1ccccc1)C(C)(C)N1CCCC1,CCN(CC)CC,ClCCl,,,,val
US20050070549A1,COC(=O)C1(C)CN(CCC=C2c3cc(C(C)(C)O)ccc3OCc3ncccc32)CCC1(O)c1ccc(Cl)cc1>>CC(C)(O)c1ccc2c(c1)C(=CCCN1CCC(O)(c3ccc(Cl)cc3)C(C)(CO)C1)c1cccnc1CO2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160237075A1,CCOC(=O)C(=CN(C)C)C(=O)c1ccc(Oc2ccccc2)cc1.NN>>CCOC(=O)c1c[nH]nc1-c1ccc(Oc2ccccc2)cc1,,CCO,,O,,val
US20120309739A1,COc1nc(NC(C)=O)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c12>>COc1nc(NC(C)=O)nc2oc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160102083A1,CCC(c1scc(C(=O)OC)c1C)N1CCC(N(C)C)CC1>>CC[C@@H](c1scc(C(=O)OC)c1C)N1CCC(N(C)C)CC1,,CO,,,,val
US05211738,CC(=O)CCN1C(=O)c2ccccc2C1=O.NO>>CC(CCN1C(=O)c2ccccc2C1=O)=NO,,CO,,Cl,[Na+].[OH-],val
US20090291079A1,CC(O)c1ccc(N)cc1.Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20150266878A1,NC(=O)C(Nc1cncc(Br)c1)c1ccccc1.OB(O)c1ccc2c(c1)OCCO2>>NC(=O)C(Nc1cncc(-c2ccc3c(c2)OCCO3)c1)c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20140023611A1,CC(C)(C)OC(=O)CCSCc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1>>O=C(O)CCSCc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04407930,CC(=O)Nc1c(OS(=O)(=O)c2ccc(C)cc2)cccc1OS(=O)(=O)c1ccc(C)cc1.O=[N+]([O-])O>>CC(=O)Nc1c(OS(=O)(=O)c2ccc(C)cc2)cc([N+](=O)[O-])cc1OS(=O)(=O)c1ccc(C)cc1,,CC(=O)OC(C)=O,,O=S(=O)(O)O,,val
US20110034464A1,CS(=O)(=O)c1ccc(Cl)cc1CN.Cl.N#CC(C(N)=O)C1OC(=O)C(Cl)=C1Cl>>CS(=O)(=O)c1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N.Cl,,CCO,,CCN(C(C)C)C(C)C,O,val
US20110124635A1,C=CCC1(c2ccc(F)cc2)CCN([C@H]2CCCN(C(=O)OC(C)(C)C)C2)C(=O)O1.OO>>CC(C)(C)OC(=O)N1CCC[C@H](N2CCC(CCCO)(c3ccc(F)cc3)OC2=O)C1,,C1CCOC1,,[Na+].[OH-],,val
US20090082332A1,CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(Cc3ccc(CC(=O)OC)cc3)[C@@H]3CCN(C(=O)OCc4ccccc4)C3)c2n1>>CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(Cc3ccc(CC(=O)OC)cc3)[C@@H]3CCN(C)C3)c2n1,[Pd],C1CCOC1,,O=C([O-])O.[Na+],,val
US20150150884A1,CN1C=CC(N)=c2ccc3c4c([nH]c(=O)c-4c21)=CCN3c1ccc(F)cc1.Cn1cc(CC(=O)O)cn1>>CN1C=CC(NC(=O)Cc2cnn(C)c2)=c2ccc3c4c([nH]c(=O)c-4c21)=CCN3c1ccc(F)cc1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05886181,CC(=O)Cl.COC(=O)C1=CNCCN1>>COC(=O)C1=CNCCN1C(C)=O,,CCOC(C)=O,,C1CCOC1,CCN(CC)CC,val
US20140213581A1,CC(C)(C)OC(=O)NC1=N[C@]2(C)c3cc([N+](=O)[O-])ccc3OCC[C@@H]2S(=O)(=O)C1(C)C.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)C1=N[C@]2(C)c3cc([N+](=O)[O-])ccc3OCC[C@@H]2S(=O)(=O)C1(C)C,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US04778912,CC(C)CCCCCCCCCCCCCCOCC(O)CO.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(C)CCCCCCCCCCCCCCOCC(O)COC(c1ccccc1)(c1ccccc1)c1ccccc1,,c1ccncc1,,,,val
US20160052930A1,CC(C)NC(=O)n1ccnc1.Cn1cc(Nc2nccc(N3C[C@@H]4CC[C@H](C3)N4)n2)cn1>>CC(C)NC(=O)N1[C@H]2CC[C@@H]1CN(c1ccnc(Nc3cnn(C)c3)n1)C2,,ClCCl,,Cl,,val
US20100063066A1,CN(C)CCCc1nn(C(=O)OC(C)(C)C)c2cccc(Nc3c(-c4ncccn4)oc4cnccc34)c12>>CN(C)CCCc1n[nH]c2cccc(Nc3c(-c4ncccn4)oc4cnccc34)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160176864A1,COC(=O)c1cc2[nH]c3cc(-c4c(C)nnn4C)cnc3c2cc1OC.O[C@@H](c1ccccc1)C1CCOCC1>>COC(=O)c1cc2c(cc1OC)c1ncc(-c3c(C)nnn3C)cc1n2[C@H](c1ccccc1)C1CCOCC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05610144,CCOC(=O)c1cc(NC(=O)NCC(=O)N2C(C(=O)OC(C)(C)C)CCC2c2ccccc2)ccc1O>>CC(C)(C)OC(=O)C1CCC(c2ccccc2)N1C(=O)CNC(=O)Nc1ccc(O)c(C(=O)O)c1,,CO,O,[K+].[OH-],,val
US20110118236A1,CCOC(=O)c1csc2c1CCNC2=O.CI>>CCOC(=O)c1csc2c1CCN(C)C2=O,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20070213341A1,C=C(C=NC(=C)O[Si](C)(C)C)CC.C[Si](C)(C)CCOCN1C(=O)/C(=C\c2cc(F)cc(F)c2)c2ccc(Cl)cc21.ClCCl>>C=C(CC)C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12,,CO,Cc1ccccc1,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20080153836A1,COC(=O)c1cc(-c2ccnn2C)c(C(C)(F)F)cc1N.CS(=O)(=O)NN.ClCCl.[OH-]>>Cn1nccc1-c1cc2c(=O)n(NS(C)(=O)=O)c(=O)[nH]c2cc1C(C)(F)F,,ClCCl,,CCN(CC)CC,,val
US20140005146A1,C[C@@H](N)C1CC1.NC(=O)c1cnn2cc(Br)cc2c1Cl>>C[C@@H](Nc1c(C(N)=O)cnn2cc(Br)cc12)C1CC1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,O,val
US20150038437A1,CC(C)(C)[Si](C)(C)Cl.OCc1cn2cc(Br)ccc2n1>>CC(C)(C)[Si](C)(C)OCc1cn2cc(Br)ccc2n1,,ClCCl,,c1c[nH]cn1,,val
US06498251B1,O=C1Nc2cccc3c2C1(CCCCBr)CCC3.c1ccc2c3c([nH]c2c1)CNCC3>>O=C1Nc2cccc3c2C1(CCCCN1CCc2c([nH]c4ccccc24)C1)CCC3,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090137557A1,CI.CN(C)C=O.O=C(O)c1cccc(F)c1O>>COc1c(F)cccc1C(N)=O,,CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06093744,CC(C)c1cc([N+](=O)[O-])cc(C(C)C)c1O.O=C=NS(=O)(=O)Cl>>CC(C)c1cc([N+](=O)[O-])cc(C(C)C)c1OS(N)(=O)=O,,Cc1ccccc1,,,,val
US20040077667A1,NC1(c2ccccc2)CCNCC1.O=c1c2c(Cl)cccc2nc2n1C(O)CC2>>NC1(c2ccccc2)CCN(CCCc2nc3cccc(Cl)c3c(=O)[nH]2)CC1,,CC#N,,CC(=O)O,[BH3-]C#N.[Na+],val
US20090137609A1,CCC(CC)(c1ccc(/C=C/C2(O)CCCCCC2)c(C)c1)c1ccc(-c2cncc(CC(=O)OC)c2)c(C)c1>>CCC(CC)(c1ccc(/C=C/C2(O)CCCCCC2)c(C)c1)c1ccc(-c2cncc(CC(=O)O)c2)c(C)c1,,CO,,[Na+].[OH-],,val
US20120149662A1,CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3cnnc4c3ccn4COC(=O)C(C)(C)C)cn2)C1>>CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3cnnc4[nH]ccc34)cn2)C1,,CO,,[Na+].[OH-],,val
US20020055631A1,[N-]=[N+]=N[C@@H]1CCCC[C@H]1Sc1ccccc1>>N[C@@H]1CCCC[C@H]1Sc1ccccc1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150218186A1,CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.FC(F)c1ncc(I)c2nc(Cl)ncc12>>CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1ncc2c(C(F)F)ncc(I)c2n1,,CC#N,,CCN(CC)CC,CCO,val
US20100093999A1,C=CC[C@H](COCc1ccccc1)OCC=NO>>c1ccc(COC[C@H]2C[C@H]3CON=C3CO2)cc1,,ClCCl,O,[Na+].[O-]Cl,,val
US20100317643A1,COCCCN.Nc1cc(NC(=O)c2c(Cl)cccc2Cl)ccn1.O=C(Cl)Oc1ccccc1>>COCCCNC(=O)Nc1cc(NC(=O)c2c(Cl)cccc2Cl)ccn1,,C1CCOC1,,c1ccncc1,,val
US20130158009A1,O=C1OCC[C@H]1O.Oc1ccc(Br)nc1>>O=C1OCC[C@@H]1Oc1ccc(Br)nc1,,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20080146565A1,CCI.CSc1nccc(-n2ccc3c(NS(C)(=O)=O)cccc32)n1>>CCN(c1cccc2c1ccn2-c1ccnc(SC)n1)S(C)(=O)=O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US06350749B1,CC(O)CN.O=C1CC(=O)CC(c2ccccc2)C1>>Cc1c[nH]c2c1C(=O)CC(c1ccccc1)C2,,C1CCOC1,,,,val
US06114572,CC(=O)Cl.Cc1cc(O)c(C)c(C)c1O>>CC(=O)Oc1c(C)cc(O)c(C)c1C,,O,,CCN(CC)CC,CCOCC,val
US20060135488A1,COC(=O)c1c(O)sc2cc(Cl)ccc12.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1c(OS(=O)(=O)C(F)(F)F)sc2cc(Cl)ccc12,,CCN(CC)CC,,ClCCl,,val
US05773607,C=[N+]=[N-].CC(=O)OC[C@H]1O[C@@H](n2cnc(C(=O)Cl)c2N=CN(C)C)[C@H](F)[C@@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@@H](n2cnc(C(=O)C=[N+]=[N-])c2N=CN(C)C)[C@H](F)[C@@H]1OC(C)=O,,CCOCC,,,,val
US20100280070A1,O=C1CC(c2ccc(Cl)cc2)Nc2c(Br)cc(Br)cc21.O=Cc1ccncc1>>O=c1c(Cc2ccncc2)c(-c2ccc(Cl)cc2)[nH]c2c(Br)cc(Br)cc12,,ClC(Cl)Cl,,C1CCNCC1,,val
US06232487B1,CC(=O)OC=C(C)Cc1ccc(C(C)(C)C)cc1.CCCCOC(=O)Cl>>CCCCOC(=O)OC=C(C)Cc1ccc(C(C)(C)C)cc1,,C1CCOC1,CCOCC,CC(C)(C)[O-].[K+],,val
US05684030,COC(=O)c1ccc(CBr)cc1.O=[N+]([O-])c1ccc2[nH]c(S)nc2c1>>COC(=O)c1ccc(CSc2nc3cc([N+](=O)[O-])ccc3[nH]2)cc1,,CCO,CO,CCN(CC)CC,Cl,val
US20110251186A1,NC1=N[C@@]2(COC1)c1cc(-c3cccnc3F)ccc1Oc1c(F)cc(C3=CCOCC3)cc12>>NC1=N[C@@]2(COC1)c1cc(-c3cccnc3F)ccc1Oc1c(F)cc(C3CCOCC3)cc12,[Pd],CCO,,[H][H],,val
US20130338134A1,COc1cc(OC)c(F)c(N2Cc3cnc4c(cc(CCN5CCOCC5)n4S(=O)(=O)c4ccccc4)c3N(C)C2=O)c1F>>COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCN5CCOCC5)cc4c3N(C)C2=O)c1F,,C1CCOC1,C1CCOC1,CC(C)(C)[O-].[K+],,val
US20160158207A1,CC(=O)N1CCC(OS(C)(=O)=O)CC1.CC(C)(C)OC(=O)N1CCc2[nH]nc(Br)c2C1>>CC(=O)N1CCC(n2nc(Br)c3c2CCN(C(=O)OC(C)(C)C)C3)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080090840A1,O=C(C[C@@H](c1ccc(OCc2ccccc2)cc1)C1C=CON1)N1C(=O)OC[C@@H]1Cc1ccccc1>>O=C(C[C@@H](c1ccc(O)cc1)C1C=CON1)N1C(=O)OC[C@@H]1Cc1ccccc1,[Pd],CCO,,,,val
US20160185775A1,CCOC(=O)c1c(C)nn2c(O)cc(C)cc12.OCC1CCCCC1>>CCOC(=O)c1c(C)nn2c(OCC3CCCCC3)cc(C)cc12,,C1CCOC1,COC(C)(C)C,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140248213A1,CC1=Nc2ccccc2C1(C)C.O=C(O)CCCCCBr>>CC1[NH+](CCCCCC(=O)O)c2ccccc2C1(C)C.[Br-],,CCO,,,,val
US20110306607A1,CCN(N)C(=O)OC(C)(C)C.CCOC(OCC)C1C(=O)c2cc(F)ccc2OC12CCN(C(=O)OC(C)(C)C)CC2.Cl>>CCn1ncc2c1-c1cc(F)ccc1OC21CCNCC1.Cl,,CCO,,,,val
US04822928,Cc1cc(Cl)c(C(C)C)cc1Cl>>Cc1cc(Cl)ccc1Cl,,Cc1ccccc1,,,,val
US20020122874A1,COc1ccc(C(=O)Nc2ncnc3c2ncn3CC(=O)OC(C)(C)C)cc1>>COc1ccc(C(=O)Nc2ncnc3c2ncn3C=C=O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04025630,Br.CCCC(C)(c1ccc(F)cc1)c1c(C)c(O)c2c(c1C)OC(C)C1CCC=CC21.O=C(O)CCCN1CCOCC1>>Br.CCCC(C)(c1ccc(F)cc1)c1c(C)c(OC(=O)CCCN2CCOCC2)c2c(c1C)OC(C)C1CCC=CC21,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100152160A1,N#CN1CC(C(=O)N2CCC(C#N)(Cc3ccc(F)cc3)CC2)Oc2ccc(Cl)cc21.[N-]=[N+]=[N-].[NH4+]>>N#CC1(Cc2ccc(F)cc2)CCN(C(=O)C2CN(c3nn[nH]n3)c3cc(Cl)ccc3O2)CC1,,CN(C)C=O,O,[Cl-].[Na+],,val
US20100197678A1,NC(=O)CI.OC(c1ccc2c(cnn2-c2cccnc2)c1)(c1c[nH]c2ccccc12)C(F)(F)F>>NC(=O)Cn1cc(C(O)(c2ccc3c(cnn3-c3cccnc3)c2)C(F)(F)F)c2ccccc21,,CN(C)C=O,,[K+].[OH-],,val
US04910190,NCc1ccccc1.O=C1CCC(=O)O1>>O=C(O)CCC(=O)NCc1ccccc1,,C1CCOC1,,,,val
US20090325900A1,COCCBr.O=Cc1c(O)ccc(F)c1F>>COCCOc1ccc(F)c(F)c1C=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060183911A1,Nc1cc(-c2ccncc2)c[nH]c1=O.O=S(=O)(Cl)c1ccccc1>>O=c1[nH]cc(-c2ccncc2)cc1NS(=O)(=O)c1ccccc1,,c1ccncc1,,,,val
US20100029650A1,CC(C)(C)OC(=O)N1CCC(COc2ccc(Cl)nn2)CC1.CS(=O)(=O)c1ccc(B(O)O)cc1>>CC(C)(C)OC(=O)N1CCC(COc2ccc(-c3ccc(S(C)(=O)=O)cc3)nn2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20080171743A1,COC(=O)c1cc(N2CCOC[C@@H]2C)nc(-c2ccc(N)cc2)n1.O=C(Cl)Oc1ccccc1>>COC(=O)c1cc(N2CCOC[C@@H]2C)nc(-c2ccc(NC(=O)Oc3ccccc3)cc2)n1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20050038033A1,CC(C)c1cc(C(=O)O)n[nH]1.CCO>>CCOC(=O)c1cc(C(C)C)[nH]n1,,O=S(=O)(O)O,,N,O,val
US06498251B1,Cl.OC1(c2ccncc2)CCc2ccccc21>>Cl.c1ccc2c(c1)CCC2C1CCNCC1,O=[Pt],CCO,,,,val
US20160272598A1,CN1C(=O)N(I)C(C)(C)C1=O.COc1ccc(CCC(=O)O)cc1>>COc1ccc(CCI)cc1,,ClCCl,,,,val
US20160145244A1,CC(=O)Cl.Cc1cc(Nc2ncnc(Nc3ccccc3S(=O)(=O)C(C)C)n2)c2c(c1C1CCNCC1)C[C@@H](C)O2>>CC(=O)N1CCC(c2c(C)cc(Nc3ncnc(Nc4ccccc4S(=O)(=O)C(C)C)n3)c3c2C[C@@H](C)O3)CC1,,ClCCl,O,CCN(CC)CC,,val
US20020072524A1,C1=CCC=C1.Fc1cccc(F)c1I>>Fc1cccc2c1C1C=CC2C1,,CCOCC,,[Li]CCCC,,val
US20020120148A1,CS(=O)(=O)O.NC(=O)COc1ccc2c(c1)CC(N(Cc1ccccc1)C[C@H](O)COc1ccccc1)CCC2>>CS(=O)(=O)O.NC(=O)COc1ccc2c(c1)CC(NC[C@H](O)COc1ccccc1)CCC2,[Pd],CCO,,[H][H],,val
US06211199B1,CCOCCn1c(NC2CCN(CCC3(Cc4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21.CS(=O)(=O)O>>CCOCCn1c(NC2CCN(CCC3(Cc4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21.CS(=O)(=O)O,,CCOC(C)=O,,,,val
US20080275102A1,C=C(C)[Mg]Br.O=[N+]([O-])c1ccccc1F>>Cc1cc2cccc(F)c2[nH]1,,C1CCOC1,,[Cl-].[NH4+],,val
US20080188528A1,COC(=O)[C@H](Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)NC(=O)c1cccn(C(c2ccccc2)c2ccccc2)c1=O>>O=C(N[C@@H](Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)C(=O)O)c1cccn(C(c2ccccc2)c2ccccc2)c1=O,,CO,,[Na+].[OH-],,val
US04350695,N.NN.Oc1nc(Cl)nc2ccccc12>>NNc1nc2ccccc2c(=O)n1N,,O,,,,val
US20070078121A1,CC(C)(C)C(=O)CC#N.Nc1ccc2c(c1)N(C(=O)C(F)(F)F)CC2.O=N[O-]>>CC(C)(C)c1cc(N)n(-c2ccc3c(c2)N(C(=O)C(F)(F)F)CC3)n1,,Cl,O,Cl[Sn]Cl,,val
US20060205774A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(I)cc2)CC1.O=C1CCN(C(=O)OCc2ccccc2)CC1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(C3(O)CCN(C(=O)OCc4ccccc4)CC3)cc2)CC1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US04868188,COc1ccc(-c2nsc3ccccc23)c(Cl)c1Cl>>Oc1ccc(-c2nsc3ccccc23)c(Cl)c1Cl,,ClCCCl,,BrB(Br)Br,,val
US20140031354A1,CN1CCNCC1.O=C(O)c1ccc([N+](=O)[O-])c([N+](=O)[O-])c1>>CN1CCN(C(=O)c2ccc([N+](=O)[O-])c([N+](=O)[O-])c2)CC1,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US05470977,CCCN(CCC)C1CCc2cccc(Br)c2C1.C[Sn](C)(C)Cl>>CCCN(CCC)C1CCc2cccc([Sn](C)(C)C)c2C1,,C1CCOC1,,O,[Li]CCCC,val
US04022897,BrBr.Nc1ncccc1O>>Nc1ncc(Br)cc1O,,CCO,,,,val
US20040067939A1,Cc1ccc2cc[nH]c2c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1ccc2c(C(=O)C(F)(F)F)c[nH]c2c1,,C1CCOC1,,,,val
US20120122840A1,C=C[Sn](CCCC)(CCCC)CCCC.Clc1nc(Cl)c2ncn(C3CCCCO3)c2n1>>C=Cc1nc(Cl)nc2c1ncn2C1CCCCO1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US05075293,CCCSP(=O)(N=C=O)OCC.COC(=O)C1CSCN1>>CCCSP(=O)(NC(=O)N1CSCC1C(=O)OC)OCC,,CCOCC,,,,val
US03932644,CC1NC(=S)NC1=O.CI>>CSC1=NC(=O)C(C)N1.I,,CCO,,,,val
US20110062165A1,COC(=O)c1cncc(Cl)c1>>OCc1cncc(Cl)c1,,CO,ClCCl,[BH4-].[Na+],,val
US05624935,CCOC(=O)c1cc2cccnc2n1C>>Cn1c(CO)cc2cccnc21,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080312226A1,O=C(Nc1ccno1)OCC(Cl)(Cl)Cl.c1ccc(-c2csc(N3CCNCC3)n2)cc1>>O=C(Nc1ccno1)N1CCN(c2nc(-c3ccccc3)cs2)CC1,,O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20040236084A1,CC(C)(C)OC(=O)N1CCN(c2ccc(N)cn2)CC1.Clc1ncc(Br)c(NC2CCCC2)n1>>CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3ncc(Br)c(NC4CCCC4)n3)cn2)CC1,,Cc1ccccc1,,,,val
US20070072853A1,CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1.NCCCO>>CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(NCCCO)c([N+](=O)[O-])c2)cc1,,CS(C)=O,O,Cl,c1ccncc1,val
US20110275611A1,C[C@@H]1CC[C@H](C(=O)O)CN1c1cc(-c2ccc(C#N)c(F)c2)nc(N)n1.NCc1ccc(F)cc1>>C[C@@H]1CC[C@H](C(=O)NCc2ccc(F)cc2)CN1c1cc(-c2ccc(C#N)c(F)c2)nc(N)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120251551A1,FC(F)(F)c1c[nH]cn1.N#Cc1ccc(Cl)nc1>>N#Cc1ccc(-n2cnc(C(F)(F)F)c2)nc1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160229865A1,C=CC(=O)N1CC(CNc2nc(Cl)nc3sccc23)C1.Cn1cc(N)cn1>>C=CC(=O)N1CC(CNc2nc(Nc3cnn(C)c3)nc3sccc23)C1,,C1COCCO1,O,c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1,O=C([O-])[O-].[Cs+].[Cs+],val
US20050137186A1,CCCN1CCc2ccc([N+](=O)[O-])cc2CC1>>CCCN1CCc2ccc(N)cc2CC1,[Pd],CCO,O,[H][H],,val
US20140045840A1,CC(C)(C)OC(=O)N(Cc1ccccc1Cl)c1ccc(C=O)c(F)n1.COc1cnc2c(c1)c(I)cn2[Si](C(C)C)(C(C)C)C(C)C>>COc1cnc2[nH]cc(Cc3ccc(NCc4ccccc4Cl)nc3F)c2c1,,C1CCOC1,,CC(C)[Mg]Cl,[Cl-].[NH4+],val
US04242510,CCOC(=O)C(=NOC)C1=CSCCN1C=O>>CON=C(C(=O)O)C1=CSCCN1C=O,,CCO,,[K+].[OH-],,val
US04845201,C(C=Cc1ccccc1)=Cc1ccccc1.[Ce]>>C(C=Cc1ccccc1)=Cc1ccccc1.[Ce],,COCCOC,,,,val
US20140256933A1,CC(C)(C)OC(=O)N1C[C@@H](CO)[C@](N)(c2ccns2)C1.O=C(N=C=S)c1ccccc1>>CC(C)(C)OC(=O)N1C[C@H]2CSC(NC(=O)c3ccccc3)=N[C@@]2(c2ccns2)C1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20090075968A1,CCN(CC)CC.Cc1ccccc1.Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)cnc2Cl)n1>>Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)cnc2NCCC2CCCC2)n1,,ClCCl,O,,,val
US20110144105A1,Cc1ccc(S(=O)(=O)OC(=CC(C)C)c2cc3cccnc3n2S(=O)(=O)c2ccccc2)cc1.Cc1cccc(B(O)O)c1>>Cc1cccc(C(=CC(C)C)c2cc3cccnc3n2S(=O)(=O)c2ccccc2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20090036492A1,CC[Sn](CC)(CC)CC.O=Cc1c(Br)ccc2c(F)c(F)c(F)cc12>>CCc1ccc2c(F)c(F)c(F)cc2c1C=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,,val
US20110237791A1,COc1nc(C=O)ccc1Cl.CSc1ccc(Br)cc1>>COc1nc(C(O)c2ccc(SC)cc2)ccc1Cl,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20100016396A1,CCN.COC(=O)[C@H](C)Oc1cc(Oc2c(CO)c(C)nn2C)c(Cl)cc1Cl.O=C(n1ccnc1)n1ccnc1>>CCNC(=O)OCc1c(C)nn(C)c1Oc1cc(O[C@@H](C)C(=O)OC)c(Cl)cc1Cl,,CN(C)C=O,,Cl,,val
US20160024009A1,COC(=O)[C@@H](N)CO.O=S(=O)(Cl)c1ccc(F)cc1>>COC(=O)[C@H](CO)NS(=O)(=O)c1ccc(F)cc1,,ClCCl,,Cl,,val
US20140228360A1,CCOC(=O)COc1cccc2c1N(C)C(=O)CO2>>CCOC(=O)COc1cccc2c1N(C)CCO2,,C1CCOC1,CO,,,val
US04916214,O=Cc1ccccc1.OCC(CO)(CBr)CBr>>BrCC1(CBr)COC(c2ccccc2)OC1,,c1ccccc1,,O=S(=O)(O)O,,val
US20110269773A1,C=C(C(=O)OC)c1ccc(Cl)c(F)c1.CC(C)[N+](=O)[O-]>>COC(=O)C(CC(C)(C)[N+](=O)[O-])c1ccc(Cl)c(F)c1,,CC#N,,C1CCC2=NCCCN2CC1,Cl,val
US20110112103A1,CI.OC1(Cc2ccc(Br)cc2)CCCCC1>>COC1(Cc2ccc(Br)cc2)CCCCC1,,CN(C)C=O,,O,[H-].[Na+],val
US20110245205A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.FC(F)c1cc(Br)cc(Nc2nccc(C(F)(F)F)n2)c1>>CC1(C)OB(c2cc(Nc3nccc(C(F)(F)F)n3)cc(C(F)F)c2)OC1(C)C,,C1COCCO1,,CC(=O)[O-].[K+],,val
US04681944,Cc1ccncc1.O=C(Cl)c1ccccc1>>O=C(Cc1ccncc1)c1ccccc1,,ClCCl,,,,val
US07074801B1,CON(C)C(=O)[C@H](C)NC(=O)OC(C)(C)C.Fc1ccc(Br)cc1>>C[C@H](NC(=O)OC(C)(C)C)C(=O)c1ccc(F)cc1,,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US06420365B1,CC(C)CCNCc1nc2ccccn2c1Cc1cc(Br)ccc1O.COc1ccc(C(=O)Cl)c(Cl)c1OC>>COc1ccc(C(=O)N(CCC(C)C)Cc2nc3ccccn3c2Cc2cc(Br)ccc2O)c(Cl)c1OC,,ClCCl,,CCN(CC)CC,,val
US06017919,CCCCCOc1c(OC)cccc1-c1cccc(C=CC(=O)OC)c1>>CCCCCOc1c(OC)cccc1-c1cccc(C=CC(=O)O)c1,,CCO,,[Na+].[OH-],,val
US20090029987A1,CN1CCNCC1.CNC(=O)c1cc(CBr)ccc1C>>CNC(=O)c1cc(CN2CCN(C)CC2)ccc1C,,C1CCOC1,,O,,val
US20090036450A1,CCNCC.COC(=O)c1sccc1S(=O)(=O)Cl>>CCN(CC)S(=O)(=O)c1ccsc1C(=O)OC,,C1CCOC1,,CCN(CC)CC,O,val
US20150031689A1,CCN=C=O.Clc1ccc(-n2c(-c3ccccc3Cl)nc3c(N[C@@H]4CCCNC4)ncnc32)cc1>>CCNC(=O)N1CCC[C@@H](Nc2ncnc3c2nc(-c2ccccc2Cl)n3-c2ccc(Cl)cc2)C1,,C1CCOC1,,CCN(CC)CC,,val
US20120129854A1,FC(F)(F)C1(c2cc(Cl)cc(Cl)c2)CCNC1.O=C1CCCc2nc(Cl)sc21>>O=C1CCCc2nc(N3CCC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)sc21,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160185751A1,NCC1CCN(CCCn2ccnn2)CC1.O=C(O)CCC(=O)O>>NCC1CCN(CCCn2ccnn2)CC1.O=C(O)CCC(=O)O,,CCO,,CCOCC,,val
US20090111797A1,Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCN(C3CCN(OC(C)(C)C)C(=C=O)C3)CC2)cc(C)c1N>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCN(C3CCNCC3)CC2)cc(C)c1N,,Cl,,O=C([O-])[O-].[K+].[K+],,val
US20130317029A1,CSc1nc(Cl)c(C#N)c(Cl)n1.Nc1cccc(-c2ncccc2F)c1>>CSc1nc(Cl)c(C#N)c(Nc2cccc(-c3ncccc3F)c2)n1,,CN(C)C=O,O,,,val
US20080161326A1,NC1CCN(Cc2ccccc2)CC1.O=S(=O)(Cl)CCCCl>>O=S(=O)(CCCCl)NC1CCN(Cc2ccccc2)CC1,,CCOCC,,,,val
US20130131016A1,Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1Br.O=C1CCC(=O)N1Br>>FC(F)(F)C1(c2cc(Cl)cc(Cl)c2)CC(c2ccc(Br)c(CBr)c2)=NO1,,ClCCCl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20120071467A1,CS(=O)(=O)Cl.O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CO[C@](CCO)(c2ccc(F)cc2)C1>>CS(=O)(=O)OCC[C@@]1(c2ccc(F)cc2)CN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CO1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20130059834A1,C[C@H](CC(=O)N1CCCC1)NC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>C[C@@H](N)CC(=O)N1CCCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04214089,Cn1ccnc1SC(CC(=O)O)C(=O)c1ccc(Cl)cc1.O>>Cn1cc[n+]2c1SC(CC(=O)O)C2(O)c1ccc(Cl)cc1.[OH-],,O,,Br,,val
US09365539B2,Brc1ncccn1.CC(C)(C)OC(=O)N1CCC(c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1>>CC(C)(C)OC(=O)N1CCC(c2cc(-c3ccc(Cl)cc3)nn2-c2ncccn2)CC1,[Cu]I,Cc1ccccc1,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US20150133457A1,C=CC(=O)Cl.COCCOc1c(F)cc(Nc2nc(Oc3cccc(N)c3)c3cc[nH]c3n2)cc1F>>C=CC(=O)Nc1cccc(Oc2nc(Nc3cc(F)c(OCCOC)c(F)c3)nc3[nH]ccc23)c1,,C1CCOC1,O,CCN(C(C)C)C(C)C,[Na+].[OH-],val
US20070088041A1,CNCc1cc(-c2cc(-c3cc4ccccc4n3C(=O)OC(C)(C)C)c(OC)nn2)cc(OC)c1OCOCC[Si](C)(C)C>>CNCc1cc(-c2cc(-c3cc4ccccc4[nH]3)c(=O)[nH]n2)cc(OC)c1O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040157885A1,CC(C)c1ccc(OCC(=O)N2CCCC(c3cccc(OC(C)(C)C(=O)OCc4ccccc4)c3)C2)cc1>>CC(C)c1ccc(OCC(=O)N2CCCC(c3cccc(OC(C)(C)C(=O)O)c3)C2)cc1,[Pd],CO,,,,val
US20110172237A1,Cc1nccc(NC(=O)CCl)n1.O=C(O[C@H]1CN2CCC1CC2)C1(c2ccccc2)CCCCCC1>>Cc1nccc(NC(=O)C[N+]23CCC(CC2)[C@@H](OC(=O)C2(c4ccccc4)CCCCCC2)C3)n1.[Cl-],,CC#N,,,,val
US20130165436A1,COc1ncc(N2CCOc3ccc(O[C@H]4CCN(C(=O)OC(C)(C)C)C4)cc32)cc1NC(=O)OC(C)(C)C>>COc1ncc(N2CCOc3ccc(O[C@H]4CCNC4)cc32)cc1N,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140100211A1,BrC1CC1.N#Cc1cc(O)ccc1Br>>N#Cc1cc(OC2CC2)ccc1Br,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060089350A1,CN(C)C(=O)CCl.NS(=O)(=O)c1cc(C(=O)O)cc(N2CCCC2)c1Oc1ccccc1>>CN(C)C(=O)COC(=O)c1cc(N2CCCC2)c(Oc2ccccc2)c(S(N)(=O)=O)c1,,CN(C)C=O,,CCN(CC)CC,[I-].[Na+],val
US20050059650A1,CN(C)C(Cl)=Nc1c(C#N)cnn1-c1ccc(S(C)(=O)=O)cc1>>CN(C)c1nc(Cl)c2cnn(-c3ccc(S(C)(=O)=O)cc3)c2n1,,ClCCCl,,Cl,,val
US20060199836A1,CCCCOC(=O)c1nc(Br)c2sccc2c1O.N#C[Cu]>>CCCCOC(=O)c1nc(C#N)c2sccc2c1O,,O,,CN(C)C=O,,val
US20130309196A1,COC(=O)C(NC(=O)OC(C)(C)C)C(C)O.O=C(O)C(F)(F)S(=O)(=O)F>>COC(=O)C(NC(=O)OC(C)(C)C)C(C)OC(F)F,[Cu]I,CC#N,CCOC(C)=O,O,,val
US20050182045A1,O=[N+]([O-])c1cnc(OCCCN2CCCCC2)nc1>>Nc1cnc(OCCCN2CCCCC2)nc1,,CO,,,,val
US20070197531A1,COC(=O)[C@@H]1CC[C@H]1CNC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NC[C@@H]1CC[C@H]1CO,,CO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20080171772A1,CC(=O)Cl.CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(O)cc2n1Cc1ccccc1>>CC(=O)Oc1ccc2c(C(=O)NCc3ccc(F)c(F)c3)c(C(C)C)n(Cc3ccccc3)c2c1,,c1ccncc1,,,,val
US20100016368A1,CCO.CCOC(=O)Cn1ncc2c1CCCC2NS(=O)(=O)c1cc(F)cc(C(F)(F)F)c1>>CCOC(=O)Cn1ncc2c1CCCC2NS(=O)(=O)c1cc(OCC)cc(C(F)(F)F)c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20020188000A1,N#Cc1ccccc1-c1cccc(-c2cnc3cc(C=O)ccn23)c1>>N#Cc1ccccc1-c1cccc(-c2cnc3cc(CO)ccn23)c1,,CO,ClC(Cl)Cl,[BH4-].[Na+],,val
US20150141400A1,CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(CN3CC[C@@H](N)C3)c(C(F)(F)F)cc2c1=O.Cc1ccc(S(=O)(=O)OCC(F)F)cc1>>CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(CN3CC[C@@H](NCC(F)F)C3)c(C(F)(F)F)cc2c1=O,,C1CCOC1,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20140171390A1,CCOC(=O)CC1(C[N+](=O)[O-])CCC(CNC(=O)OC(C)(C)C)CC1>>CC(C)(C)OC(=O)NCC1CCC(CC(=O)O)(C[N+](=O)[O-])CC1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20090156607A1,CCCC1CC(=O)N(Cc2cncn2CC(=O)O)C1.NCc1ccccc1>>CCCC1CC(=O)N(Cc2cncn2CC(=O)NCc2ccccc2)C1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20100216746A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)Nc1ccc2[nH]c(C(=O)NCc3ccc(Cl)c(Oc4cc(Cl)cc(C#N)c4)c3F)cc2c1.O=C(O)C(F)(F)F>>N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CNC(=O)c3cc4cc(NC(=O)[C@@H]5CCCN5)ccc4[nH]3)c2F)c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20090105219A1,CC(C)(C)OC(=O)CBr.CCOC(=O)CCC1CNc2cccc([N+](=O)[O-])c21>>CCOC(=O)CCC1CN(CC(=O)OC(C)(C)C)c2cccc([N+](=O)[O-])c21,,CC(C)=O,,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US05106871,COCOc1ccc(C(=O)C=Cc2ccc(OCOC)c(OCOC)c2)c(OCOC)c1>>COCOc1ccc(C(=O)CCc2ccc(OCOC)c(OCOC)c2)c(OCOC)c1,[Pd],,,,,val
US20120283264A1,CCOP(=O)(Cc1cc(F)ccc1F)OCC.Clc1ccnc(CBr)n1>>CCOP(=O)(Cc1nccc(Cl)n1)OCC,,CC#N,,O,O=C(O)C(F)(F)F,val
US20160021883A1,Nc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1.O=C=Nc1ccc(F)cc1>>O=C(Nc1ccc(F)cc1)Nc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1,,C1CCOC1,,,,val
US20100234364A1,C1COCCN1.O=C(O)c1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1>>O=C(c1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1)N1CCOCC1,,ClCCl,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20070043065A1,C1CSCCN1.Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(OOCC(C)Cl)cc2c1=O>>Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(OCCCN3CCSCC3)cc2c1=O,,CC(=O)N(C)C,,[I-].[K+],,val
US20100298336A1,CCI.Cc1nc[nH]c1C=O>>CCn1cnc(C=O)c1C,,C1CCOC1,,O,,val
US20070249615A1,CCCOCCNc1cc(Cl)ncc1NC(=O)OC(C)(C)C>>CCCOCCNc1cc(Cl)ncc1N,,C1COCCO1,,Cl,,val
US20040133008A1,Cc1ccc(C(=O)Nc2ccc3c(c2)CCN3C(=O)OC(C)(C)C)c(OC(C)C)c1>>Cc1ccc(C(=O)Nc2ccc3c(c2)CCN3)c(OC(C)C)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040087798A1,O=CN(C=O)CC(=O)c1ccc([N+](=O)[O-])cc1>>O=CNCC(=O)c1ccc([N+](=O)[O-])cc1,CCN(CC)CC,CO,,,,val
US20090227622A1,CC(=O)O.CC(C)(C)c1cc(NC(=O)Cc2ccc(-c3cnc4cc(-c5ccc(S(=O)(=O)CCN)cc5)ccn34)cc2)no1.CC=O>>CCN(CC)CCS(=O)(=O)c1ccc(-c2ccn3c(-c4ccc(CC(=O)Nc5cc(C(C)(C)C)on5)cc4)cnc3c2)cc1,,CO,,[BH3-]C#N.[Na+],,val
US04264599,O=C1NCCN1C1CCNCC1.O=[N+]([O-])c1ncccc1OCC1CO1>>O=C1NCCN1C1CCN(CC(O)COc2cccnc2[N+](=O)[O-])CC1,,CC(C)O,,ClCCl,,val
US04935430,Cc1cc(Nc2ccc(C#N)cc2)c([N+](=O)[O-])c(C)n1>>Cc1cc(Nc2ccc(C#N)cc2)c(N)c(C)n1,[Pd],CCO,ClCCl,,,val
US04703052,BrCc1ccccc1.O=S1(=O)CCCc2cc(C3OCCO3)ccc21>>O=Cc1ccc2c(c1)CCC(Cc1ccccc1)S2(=O)=O,,C1CCOC1,,[Li]CCCC,,val
US20120232286A1,C=O.COC(=O)C1(Cc2ccc(Cl)cc2)CCC(C)C1=O>>COC(=O)C1(Cc2ccc(Cl)cc2)CCC(C)(CO)C1=O,,O,,O=C([O-])[O-].[K+].[K+],,val
US20030030033A1,CC(=O)CC(=O)Nc1ccc(Nc2ccccc2)cc1.N>>CC(N)CC(=O)Nc1ccc(Nc2ccccc2)cc1,[Ni],Cc1ccccc1,,[H][H],,val
US20140005213A1,Cc1ccc2cc(F)cc(OC(C)C)c2n1.O=[Se]=O>>CC(C)Oc1cc(F)cc2ccc(C=O)nc12,,C1COCCO1,O,,,val
US09365539B2,CC(C)(C)OC(=O)N1CCC(C(=O)NC(=S)c2ccc(F)cc2)CC1.NNc1ncccn1>>CC(C)(C)OC(=O)N1CCC(c2nc(-c3ccc(F)cc3)nn2-c2ncccn2)CC1,,C1COCCO1,CC(=O)O,CC(=O)[O-].[Na+],,val
US20150152108A1,NC(=O)CCl.O=C(Nc1cccc(C2CCNC2)c1)N1c2nc(-c3cccc(C(F)(F)F)c3)ccc2N2CC[C@H]1C2>>NC(=O)CN1CCC(c2cccc(NC(=O)N3c4nc(-c5cccc(C(F)(F)F)c5)ccc4N4CC[C@H]3C4)c2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060247300A1,O=C(OCc1ccccc1)N1CCC2(C1)OCCO2>>C1CC2(CN1)OCCO2,[Pd],CCO,,,,val
US20030027847A1,CNC(=O)c1cccc(Br)c1.O=Cc1ccc(F)cc1>>CNC(=O)c1cccc(C(O)c2ccc(F)cc2)c1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20140057937A1,CC(C(=O)O)c1ccc(Cl)c(C(F)(F)F)c1.Fc1ccc(-n2ncc3c2CCCN3)cc1>>CC(C(=O)N1CCCc2c1cnn2-c1ccc(F)cc1)c1ccc(Cl)c(C(F)(F)F)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20140275111A1,O=[N+]([O-])c1ccc(F)c(C(F)(F)F)c1.OCCOCc1ccccc1>>O=[N+]([O-])c1ccc(OCCOCc2ccccc2)c(C(F)(F)F)c1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20150322043A1,CCOC(=O)c1cc(NC(=O)c2cc(-c3ccc(F)cn3)c(Cl)cc2Cl)n(-c2ccccc2)n1>>O=C(O)c1cc(NC(=O)c2cc(-c3ccc(F)cn3)c(Cl)cc2Cl)n(-c2ccccc2)n1,,CCO,,[Na+].[OH-],,val
US20130310395A1,COC(=O)c1cnc(N2CC[C@@H](O)C2)c(-c2ccnn2C2CCCCO2)c1>>O=C(O)c1cnc(N2CC[C@@H](O)C2)c(-c2ccnn2C2CCCCO2)c1,,CO,,[Na+].[OH-],,val
US04343811,Cc1[nH]c2c(c1-c1ccccc1)C(=O)CCC2>>Cc1[nH]c2cccc(O)c2c1-c1ccccc1,[Pd],CCOCC,,,,val
US05324722,CC(=O)OC(C)=O.Nc1cc(Cl)ccc1Oc1ccccc1>>CC(=O)Nc1cc(Cl)ccc1Oc1ccccc1,,c1ccncc1,,,,val
US20130096113A1,CC1(C)O[C@@H]2CCCC[C@H]2N1c1nc2ccc(CNc3ncnc(Cl)c3[N+](=O)[O-])cc2s1>>CC1(C)O[C@@H]2CCCC[C@H]2N1c1nc2ccc(CNc3ncncc3N)cc2s1,[Pd],CO,,CCOC(C)=O,,val
US20070099990A1,C1CCNC1.Cc1c(C)c2c(c(C)c1NC(=O)CC(C)(C)C)C(O)C(C)(C)O2>>Cc1c(C)c2c(c(C)c1NC(=O)CC(C)(C)C)C(N1CCCC1)C(C)(C)O2,,CCCCCC,CCOC(C)=O,,,val
US06465451B1,CCCCC(CC)(CBr)C(=O)O.COc1cc2sc(N)nc2cc1Cl>>CCCCC(CC)(CSc1cc(OC)c(Cl)cc1N)C(=O)O,,O,,Cl,[K+].[OH-],val
US20120142625A1,CN(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21)C1CC(CO)C1.CS(=O)(=O)Cl>>CN(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21)C1CC(COS(C)(=O)=O)C1,,ClCCl,,CCN(CC)CC,O,val
US04985419,CC(CN1CCCC1)N1c2ccccc2Sc2ccc(C(=O)Cl)cc21.NCc1ccccc1[N+](=O)[O-]>>CC(CN1CCCC1)N1c2ccccc2Sc2ccc(C(=O)NCc3ccccc3[N+](=O)[O-])cc21,,ClCCl,,Cl,,val
US20130029968A1,N#Cc1ccc(C(=O)O)cn1.O=S(Cl)Cl>>N#Cc1ccc(C(=O)Cl)cn1,CN(C)C=O,Cc1ccccc1,,,,val
US05804532,CCOC=C(C(=O)c1ccc(S(C)(=O)=O)cc1Cl)C(=O)C1CC1.NO>>CS(=O)(=O)c1ccc(C(=O)c2cnoc2C2CC2)c(Cl)c1,,CC#N,,CCN(CC)CC,Cl,val
US20080090801A1,COc1ccc(B(O)O)cn1.Cc1nc(N)nc2c1cc(Br)c(=O)n2[C@@H]1CC[C@H](OCCO)CC1>>COc1ccc(-c2cc3c(C)nc(N)nc3n([C@@H]3CC[C@H](OCCO)CC3)c2=O)cn1,Cl[Pd]Cl,,,O=C([O-])[O-].[K+].[K+],,val
US20120101100A1,COC(=O)c1cc(Br)ccn1.NN>>NNC(=O)c1cc(Br)ccn1,,CCO,,O,,val
US20110009454A1,CCCCCCc1cccc(CN)c1.Nc1ncccc1C(=O)O>>CCCCCCc1cccc(CNC(=O)c2cccnc2N)c1,,CN(C)C=O,O,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20150038528A1,COC(=O)c1ncc2cc(NCc3ccc(OC)cc3)ccc2c1OCc1ccccc1>>COC(=O)c1ncc2cc(NCc3ccc(OC)cc3)ccc2c1O,[Pd],CCO,CCOC(C)=O,,,val
US04512924,COC(=O)C1CCCN2CC(N=[N+]=[N-])C(=O)N12>>NC1CN2CCCC(C(=O)O)N2C1=O,,C1COCCO1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05977101,N#Cc1cc2ccccc2[nH]1>>NCc1cc2ccccc2[nH]1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05053072,CCOC(=O)c1nc(C)cc(OC)n1>>COc1cc(C)nc(C(=O)O)n1,,CCO,O,[Na+].[OH-],,val
US04521241,CN1Cc2cccc(S(=O)(=O)NC(C)(C)C)c2C1.Cl>>CN1Cc2cccc(S(N)(=O)=O)c2C1.Cl,,CO,,B,,val
US20120208798A1,CC(=O)N1c2ccc(C(=O)O)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.CC(C)(C)OC(=O)NCC(=N)NO>>CC(=O)N1c2ccc(-c3nc(CNC(=O)OC(C)(C)C)no3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060004017A1,CNC.COc1cc2c(Oc3ccc4[nH]ccc4c3)ncnc2cc1OC[C@@H]1CO1>>COc1cc2c(Oc3ccc4[nH]ccc4c3)ncnc2cc1OC[C@@H](O)CN(C)C,,C1CCOC1,CN(C)C=O,,,val
US20110213157A1,COC(=O)c1ccc(C(=O)Nc2cc3c4c(c2)CCCC4(C)CCC3)s1>>CC12CCCc3cc(NC(=O)c4ccc(C(=O)O)s4)cc(c31)CCC2,,CCO,,Cl,[Na+].[OH-],val
US20090275542A1,BrC(Br)(Br)Br.CC(C)(C)OC(=O)N1CCC(O)C1>>CC(C)(C)OC(=O)N1CCC(Br)C1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100197654A1,COC(=O)[C@@H]1C[C@H](OC)CN1C(=O)OCc1ccccc1.Nc1cnccn1>>CO[C@H]1C[C@@H](C(=O)Nc2cnccn2)N(C(=O)OCc2ccccc2)C1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20050154230A1,Nc1ccccc1CCO.O=C(Nc1cccc(OC(F)(F)F)c1)Oc1ccccc1>>O=C(Nc1cccc(OC(F)(F)F)c1)Nc1ccccc1CCO,,CCOC(C)=O,CS(C)=O,,,val
US20140179680A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(N1CC[C@@H]2[C@@H](C1)OCCN2Cc1ccccc1)C(F)(F)F>>CC(C)(C)OC(=O)N1CCOC2CN(C(=O)C(F)(F)F)CCC21,[Pd],CO,,,,val
US08642642B2,COC(=O)N1CCC(c2cccc(NS(=O)(=O)c3cccc(OC(F)(F)F)c3)c2)C1>>O=S(=O)(Nc1cccc(C2CCNC2)c1)c1cccc(OC(F)(F)F)c1,,CCO,,Cl,,val
US20120208817A1,CCOc1cc(C=O)cc([N+](=O)[O-])c1O.Cl.N=C(N)N.O=C(Cc1ccccc1)c1ccccc1>>CCOc1cc(C2NC(=N)NC(c3ccccc3)=C2c2ccccc2)cc([N+](=O)[O-])c1O.Cl,,CCO,,CC(C)NC(C)C,,val
US20130137661A1,CC(C)(C)OC(=O)CBr.Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NC(=O)OC(C)(C)C)c2ccccc2O)c(=O)n1Cc1c(F)cccc1C(F)(F)F>>Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NC(=O)OC(C)(C)C)c2ccccc2OCC(=O)OC(C)(C)C)c(=O)n1Cc1c(F)cccc1C(F)(F)F,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US05202335,C1CC[C@@H]2CNC[C@@H]2C1.O=C1C/C(=C\c2ccccc2)C(=O)O1>>O=C(O)/C(=C/c1ccccc1)CC(=O)N1C[C@@H]2CCCC[C@@H]2C1,,ClCCl,,,,val
US06174839B1,CCOc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(F)cc1Br.CI>>CCOc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Br,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140213578A1,O=S(=O)(NCC(O)CN1c2ccccc2CCc2ccccc21)c1ccc(OC(F)(F)F)cc1>>O=C(CNS(=O)(=O)c1ccc(OC(F)(F)F)cc1)CN1c2ccccc2CCc2ccccc21,,CS(C)=O,,CCN(CC)CC,,val
US20050245563A1,COC(=O)c1cc([N+](=O)[O-])ccc1NC(=O)CC(C)=O>>CC(=O)C1C(=O)Nc2ccc([N+](=O)[O-])cc2C1=O,,CO,,C[O-].[Na+],,val
US20160159752A1,C[Si](C)(C)CCOC(=O)NC1CC(=O)CC1CC[C@H]1CN(C(=O)OCc2ccccc2)CCN1S(=O)(=O)c1ccccc1>>C[Si](C)(C)CCOC(=O)NC1CC(O)CC1CC[C@H]1CN(C(=O)OCc2ccccc2)CCN1S(=O)(=O)c1ccccc1,,C1CCOC1,CO,[BH4-].[Na+],,val
US20140275030A1,CC(C)N.Cc1noc(C)c1-c1cc(C=O)c2[nH]c(=O)n3c2c1OC[C@@H]3c1ccccn1>>Cc1noc(C)c1-c1cc(CNC(C)C)c2[nH]c(=O)n3c2c1OCC3c1ccccn1,,CO,,[BH3-]C#N.[Na+],,val
US20140005188A1,CC(C)(C)OC(=O)N1CCC[C@H](CNc2nc(Cl)cc3nccnc23)C1.CC1(C)OB(c2cnn(Cc3ccccc3)c2)OC1(C)C>>CC(C)(C)OC(=O)N1CCC[C@H](CNc2nc(-c3cnn(Cc4ccccc4)c3)cc3nccnc23)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20020038030A1,CC(=O)Nc1cc(-c2ccccc2C)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1.CI>>CC(=O)N(C)c1cc(-c2ccccc2C)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20040072832A1,CC(=O)Cc1c([N+](=O)[O-])ccc(OCc2ccccc2)c1F>>Cc1cc2c(F)c(OCc3ccccc3)ccc2[nH]1,[Ni],CO,,NN,,val
US20040254156A1,COC(=O)Cc1ccccc1Br.N#C[Cu]>>COC(=O)Cc1ccccc1C#N,Cl[Fe](Cl)Cl,CN(C)C=O,O,,,val
US20090264431A1,CC(C)(C)OC(=O)N1C[C@H](NS(=O)(=O)c2cc(Br)ccc2Br)C[C@@H]1CN.O=C(Cl)Oc1ccccc1>>CC(C)(C)OC(=O)N1C[C@H](NS(=O)(=O)c2cc(Br)ccc2Br)C[C@@H]1CNC(=O)Oc1ccccc1,,C1CCOC1,ClCCl,,,val
US06114325,CCCCCCCCCCCCCCCCCCN(C=O)c1ccccc1COC(=O)NN(C)C.Cl>>CCCCCCCCCCCCCCCCCCN(C=O)c1ccccc1COC(=O)NN(C)C.Cl,,CCOC(C)=O,,,,val
US20130053412A1,CI.O=C(Nc1ccc(-c2cn3ccccc3n2)cc1)C(F)(F)F>>CN(C(=O)C(F)(F)F)c1ccc(-c2cn3ccccc3n2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20010051631A1,Cl.O=C1c2cnc3cccc(n23)CN1CCCC1CCN(S(=O)(=O)C(F)(F)F)CC1>>Cl.O=C1c2cnc3cccc(n23)CN1CCCC1CCN(S(=O)(=O)C(F)(F)F)CC1,,CCO,,,,val
US20050256037A1,CN(C(=O)[C@H](C[C@H](CNC(=O)OCc1ccccc1)O[Si](C)(C)C(C)(C)C)NC(=O)OC(C)(C)C)[C@@H](Cc1cc(-c2ccc(OCc3ccccc3)c(C[C@H](NC(=O)OCc3ccccc3)C(=O)OCC[Si](C)(C)C)c2)ccc1OCc1ccccc1)C(=O)OCc1ccccc1>>CN(C(=O)[C@H](C[C@@H](O)CNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C)[C@@H](Cc1cc(-c2ccc(OCc3ccccc3)c(C[C@H](NC(=O)OCc3ccccc3)C(=O)O)c2)ccc1OCc1ccccc1)C(=O)OCc1ccccc1,,CN(C)C=O,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05532240,CC(=O)N1CCCc2ccsc2C1.O=C(Cl)CCCCl>>CC(=O)N1CCCc2cc(C(=O)CCCCl)sc2C1,,ClCCl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US06177449B1,CCCBr.CCS(=O)(=O)NC1CC(C)(C)Oc2ccc(OCc3ccccc3)cc21>>CCCN(C1CC(C)(C)Oc2ccc(OCc3ccccc3)cc21)S(=O)(=O)CC,,CC(=O)N(C)C,,[H-].[Na+],,val
US20150361100A1,CC(N)c1cc2ccccn2c1C1=CCN(C(=O)OC(C)(C)C)CC1.N#Cc1c(N)ncnc1Cl>>CC(Nc1ncnc(N)c1C#N)c1cc2ccccn2c1C1=CCN(C(=O)OC(C)(C)C)CC1,,CC(C)(C)O,,CCN(C(C)C)C(C)C,,val
US20090181928A1,CC(=O)c1c(O)cccc1OCc1ccccc1.CC(C)(C)OC(=O)NCCCCI>>CC(=O)c1c(OCCCCNC(=O)OC(C)(C)C)cccc1OCc1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06281221B1,Cc1ccc(C2SCC(=O)CS2)cc1.[NH4+]>>Cc1ccc(C2SCC(N)CS2)cc1,,CO,,[BH3-]C#N.[Na+],,val
US20120142677A1,CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2)on1.O=C(Cl)N1CCOCC1>>CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2C(=O)N2CCOCC2)on1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,Cl,val
US04667038,CI.COc1ccc(C(C#N)(CCCC2Cc3cc(OC)c(OC)cc3C=N2)C(C)C)cc1OC>>COc1ccc(C(C#N)(CCCC2Cc3cc(OC)c(OC)cc3C=[N+]2C)C(C)C)cc1OC.[I-],,CC(C)=O,,,,val
US20050222146A1,CN(C)C(OC(C)(C)C)OC(C)(C)C.C[C@@H]1[C@H](c2ccccc2)[C@]1(NC(=O)OC(C)(C)C)C(=O)O>>C[C@@H]1[C@H](c2ccccc2)[C@]1(NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20060261730A1,NN.O=C(c1ccccc1)c1ccccc1C(=O)c1ccccc1>>c1ccc(-c2nnc(-c3ccccc3)c3ccccc23)cc1,,CC(=O)O,,O,O,val
US20050171062A1,COC(=O)CCCC=CCN1C(=O)CCC[C@@H]1/C=C/C(=O)Cc1ccccc1>>COC(=O)CCCC=CCN1C(=O)CCC[C@@H]1/C=C/C(O)Cc1ccccc1,,ClCCl,,CO,[BH4-].[Na+],val
US20150218170A1,CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Nc3ccc(S(C)(=O)=O)nc3)nc12>>CC(C)(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(S(C)(=O)=O)nc3)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US05981533,CCOC(OCC)N(C)C.N#Cc1c(NCc2ccccc2)n[nH]c1N>>CN(C)C=Nc1[nH]nc(NCc2ccccc2)c1C#N,,Cc1ccccc1,,,,val
US20080292608A1,CC(C)(C)[Si](C)(C)Cl.COC(=O)CCc1cc(Br)c(O)cc1C>>COC(=O)CCc1cc(Br)c(O[Si](C)(C)C(C)(C)C)cc1C,,ClCCl,,c1c[nH]cn1,,val
US20080167307A1,CC(C)(C)OC(=O)C(C)(C)Sc1nc(CC(=O)OCC2c3ccccc3-c3ccccc32)cs1>>CC(C)(Sc1nc(CC(=O)OCC2c3ccccc3-c3ccccc32)cs1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US05330986,CN1CCNCC1.O=C(O)c1cccc2cc[nH]c12>>CN1CCN(C(=O)c2cccc3cc[nH]c23)CC1,,CN(C)C=O,,,,val
US20150374705A1,CC(C)(C)c1c(O)nn2c(-c3cc(CO)on3)nncc12.Cn1ncnc1CCl>>Cn1ncnc1COc1nn2c(-c3cc(CO)on3)nncc2c1C(C)(C)C,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US05472964,Clc1cc2nc(CBr)ccc2s1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Clc1cc2nc(C[P+](c3ccccc3)(c3ccccc3)c3ccccc3)ccc2s1.[Br-],,CCOCC,,,,val
US20050096306A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.Cn1ncc(NC(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)OCc2ccccc2)c1N>>Cn1ncc(NC(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)OCc2ccccc2)c1NC(c1ccccc1)(c1ccccc1)c1ccccc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20040229862A1,CCOC(=O)Cl.COc1ccc(N2CCOCC2)c2sc(-c3nc4c([nH]3)CCNCC4)nc12>>CCOC(=O)N1CCc2nc(-c3nc4c(OC)ccc(N5CCOCC5)c4s3)[nH]c2CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20110028449A1,COC(=O)c1ccc(O)c(C=O)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1ccc(OS(=O)(=O)C(F)(F)F)c(C=O)c1,,ClCCl,,c1ccncc1,,val
US20040127536A1,COCC(=O)Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4nnn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1>>COCC(=O)Nc1cccc(-c2n[nH]c3ccc(-c4nn[nH]n4)cc23)c1,,C1COCCO1,Cl,[Na+].[OH-],,val
US20020045618A1,CC(C)(C)OC(=O)N1CCCN(c2cncc(Cl)c2)CC1.CC1(C)C(=O)N(Cl)C(=O)N1Cl>>CC(C)(C)OC(=O)N1CCCN(c2cnc(Cl)c(Cl)c2)CC1,,ClCCl,,,,val
US20090253687A1,Nc1nnc(SCc2ccccc2)s1.O=CCCl>>c1ccc(CSc2nn3ccnc3s2)cc1,,CCO,Cc1ccccc1,,,val
US20100173901A1,CC1(C)OB(c2cn[nH]c2)OC1(C)C.CCOc1ccc(CCl)cn1>>CCOc1ccc(Cn2cc(B3OC(C)(C)C(C)(C)O3)cn2)cn1,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20150353499A1,CCOc1ccc2ccccc2c1C(=O)O>>CCOc1ccc2ccccc2c1CO,,ClCCl,O,C1CCOC1,,val
US04604390,O=[N+]([O-])c1ccc2c3c(nn2CCN(CCOCc2ccccc2)Cc2ccccc2)-c2cc(O)ccc2Oc13>>Nc1ccc2c3c(nn2CCN(CCOCc2ccccc2)Cc2ccccc2)-c2cc(O)ccc2Oc13,[Ni],CN(C)C=O,,,,val
US04065473,COc1cc(CCNCc2ccccc2)c(CC(=O)O)cc1OC>>COc1cc2c(cc1OC)CC(=O)N(Cc1ccccc1)CC2,,Cc1ccccc1C,,,,val
US20050020591A1,N#Cc1ccc(CCN=[N+]=[N-])cc1>>N#Cc1ccc(CCN)cc1,[Pd],CCO,CCOC(C)=O,N#N,,val
US20100210641A1,Brc1ccn2ccnc2c1.CNC(=O)c1cccc(B(O)O)c1>>CNC(=O)c1cccc(-c2ccn3ccnc3c2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US20040220404A1,COc1cc(N)ccc1OCCN1CCCC1.O=C(Cl)c1ccc(Cl)cc1[N+](=O)[O-]>>COc1cc(NC(=O)c2ccc(Cl)cc2[N+](=O)[O-])ccc1OCCN1CCCC1,,ClCCl,,CCN(CC)CC,,val
US20090137607A1,N#Cc1ccc[nH]1.NN>>NN=C(N)c1ccc[nH]1,,CCO,O,C[O-].[Na+],,val
US20090143381A1,CN(C)CCO.O=C(Cl)c1cccc(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)cc3ccccc23)c1>>CN(C)CCOC(=O)c1cccc(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)cc3ccccc23)c1,,ClCCl,ClCCl,,,val
US20140315902A1,COc1cc(OC)c(F)c(NCc2cnc(Cl)c(C)c2Cl)c1F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc(OC)c(F)c(N(Cc2cnc(Cl)c(C)c2Cl)C(=O)Cl)c1F,,ClCCl,,c1ccncc1,,val
US20040009995A1,CCOC(C)=O.COC(=O)c1ccc(OCCCCCN)cc1.CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(-c2c(C)cc(NC(=O)OCC[Si](C)(C)C)cc2N)c1>>COC(=O)c1ccc(OCCCCCNC(=O)Nc2cc(NC(=O)OCC[Si](C)(C)C)cc(C)c2-c2cccc(S(=O)(=O)c3cc(C(=N)NC(=O)OC(C)(C)C)sc3SC)c2)cc1,,ClCCl,,CCN(CC)CC,c1ccncc1,val
US04093812,CCOC(=O)NN.O=Cc1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1>>CCOC(=O)NN=Cc1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1,CC(=O)O,O,,CCO,,val
US05783704,CC1CN(N)C(=O)N1C.Cl.O=Cc1cccnc1>>CC1CN(N=Cc2cccnc2)C(=O)N1C.Cl,,CO,,,,val
US20120277212A1,CC(C)(C)ON=c1cc(-c2cc3cccn3cn2)oc2ccc(O)cc12.ClCCCl>>CC(C)(C)ON=c1cc(-c2cc3cccn3cn2)oc2ccc(OCCCl)cc12,,CN(C)C=O,,,,val
US20110034464A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COCCSc1ccccc1CN>>COCCSc1ccccc1CNC(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20130210844A1,CC(C)(C)C(=O)Cl.COC(=O)c1cc(CN)c(F)cc1Cl>>COC(=O)c1cc(CNC(=O)C(C)(C)C)c(F)cc1Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120095014A1,CC(C)[Si](Sc1ccc2c(c1)CN(CC(F)(F)F)C2=O)(C(C)C)C(C)C>>O=C1c2ccc(S)cc2CN1CC(F)(F)F,,C1CCOC1,CO,Cl,,val
US20070219374A1,Nc1ccccc1.O=C1CCC(=O)CC1>>Oc1ccc(Nc2ccccc2)cc1,,CCO,,CCN(CC)CC,,val
US20090163488A1,O=C(Nc1nc2cc(Oc3cccc([N+](=O)[O-])c3)ccn2n1)C1CC1>>Nc1cccc(Oc2ccn3nc(NC(=O)C4CC4)nc3c2)c1,,O=C([O-])O,[Na+],CCO,Cl,val
US20020161014A1,Nc1cc(F)c(F)cc1C(=O)Nc1ccccc1Cl.O=C(Cl)CCl>>O=c1c2cc(F)c(F)cc2nc(CCl)n1-c1ccccc1Cl,,CC(=O)O,,,,val
US20040024034A1,CCCCc1ccc(O)cc1OCCc1nc(-c2ccccc2)oc1C.CCOC(=O)C(C)(C)Br>>CCCCc1ccc(OC(C)(C)C(=O)OCC)cc1OCCc1nc(-c2ccccc2)oc1C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050148624A1,COC(=O)c1ccc(SCc2ccc(Cn3c(C(=O)OC)c(-c4ccccc4)c4cc(Br)ccc4c3=O)cc2)cc1.O=C(OO)c1cccc(Cl)c1>>COC(=O)c1ccc(S(=O)Cc2ccc(Cn3c(C(=O)OC)c(-c4ccccc4)c4cc(Br)ccc4c3=O)cc2)cc1,,ClCCl,,,,val
US05849857,CC(=O)[O-].CC(C)(c1ccc(O)cc1)c1ccc(O)cc1.Cc1ccccc1.O=C1OC(=O)C2CCC=CC12>>CC(=O)[O-].O=CC12CC=CCC1C1CC=CCC1O2,,Cc1ccccc1,,,,val
US20070037802A1,Cc1ccc(S(=O)(=O)OCCCOc2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)cc1.NC1CCCC1>>O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(OCCCNC3CCCC3)cc12,,C1CCOC1,,,,val
US05599814,CCc1cc(Br)cc2c1C(=O)C(=O)N2.O=C(O)c1cccc(OO)c1C(=O)O>>CCc1cc(Br)cc2[nH]c(=O)oc(=O)c12,,CC(=O)O,,O,,val
US04946917,C=CC(=O)NCC(C(C)=O)C(=O)c1ccccc1.NNc1ccccc1>>C=CC(=O)NCc1c(C)nn(-c2ccccc2)c1-c1ccccc1,,O,,CC(=O)O,,val
US20100099736A1,Cc1cccc(C2=CC(=O)OC2=O)c1.Nc1cccc(Cl)c1>>Cc1cccc(C2=CC(=O)N(c3cccc(Cl)c3)C2=O)c1,,CC(=O)O,,,,val
US04731106,Nc1ccc(I)cc1C(=O)O.O=C=Nc1ccc(Cl)cc1>>O=C(Nc1ccc(Cl)cc1)Nc1ccc(I)cc1C(=O)O,,CCOC(C)=O,,,,val
US20060264427A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=[N+]([O-])c1ccc(O)c2oc3ccccc3c12>>O=[N+]([O-])c1ccc(OS(=O)(=O)C(F)(F)F)c2oc3ccccc3c12,,ClCCl,,CCN(CC)CC,,val
US20150119385A1,CCOC(=O)CSCCNCc1cc2c(nc1C(OC)OC)NCCC2>>COC(OC)c1nc2c(cc1CN1CCSCC1=O)CCCN2,,Cc1ccccc1,,,,val
US05409943,CCOC(=N)Cc1ccccc1.Cl.Nc1ncccc1OCc1c(F)cccc1F>>Cl.N=C(Cc1ccccc1)Nc1ncccc1OCc1c(F)cccc1F,,CCO,,,,val
US20150344485A1,CC(N)CCBr.Clc1cc(Cl)nc(Cl)n1>>CC(CCBr)Nc1cc(Cl)nc(Cl)n1,,CC#N,,,,val
US20060135556A1,Cc1ccc2c(C)ccc([N+](=O)[O-])c2c1>>Cc1ccc2c(C)ccc(N)c2c1,[Ni],CCO,,,,val
US20140213586A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1cc(N)cc(O)c1>>COc1cc(O)cc(NC(=O)OC(C)(C)C)c1,,C1CCOC1,CCOC(C)=O,,,val
US20060014778A1,CCOC(=O)C1(C(=O)OCC)CN(Cc2ccccc2)CC1c1cccc(OC)c1[N+](=O)[O-]>>CCOC(=O)[C@@]12CNC[C@@H]1c1cccc(OC)c1NC2=O,[Pd],CO,,[H][H],,val
US04356118,COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)C(C)CSC(C)=O)C(C)(C)C>>CC(CS)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)(C)C,,CCO,,[Na+].[OH-],,val
US20030092714A1,CCCI.Cc1cnc(S)nc1-c1c[nH]c(C(=O)N[C@H](CO)c2ccccc2)c1>>CCCSc1ncc(C)c(-c2c[nH]c(C(=O)N[C@H](CO)c3ccccc3)c2)n1,,N,,,,val
US20050148670A1,CC(C)OB(OC(C)C)OC(C)C.CCOCOc1cc(Br)cc2c1C(C)(C)CCC2(C)C>>CCOCOc1cc(B(O)O)cc2c1C(C)(C)CCC2(C)C,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20080039444A1,CS(=O)(=O)OCCCCc1ccc(OCCCN2CCCCCC2)cc1.O=c1c2ccccc2c(Cl)nn1C[C@H]1CCCN1>>O=c1c2ccccc2c(Cl)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1,,CC#N,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US05750471,CCN1c2c(Cl)cc(F)c(N)c2CS1(=O)=O.S=C(Cl)Cl>>CCN1c2c(Cl)cc(F)c(N=C=S)c2CS1(=O)=O,,C1CCOC1,,CCN(CC)CC,,val
US04935431,CCOC(=O)c1cnc2c(C)csc2c1Cl.NCc1ccccc1>>CCOC(=O)c1cnc2c(C)csc2c1NCc1ccccc1,,ClC(Cl)Cl,,,,val
US20130116263A1,CSc1ncc2ccc(=O)n(C3CCCC3)c2n1.O=C1CCC(=O)N1Br>>CSc1ncc2cc(Br)c(=O)n(C3CCCC3)c2n1,,CN(C)C=O,,O,,val
US20090023731A1,Nc1cccnc1.O=C(Nc1cccc(OCCCN2CCOCC2)c1)Oc1ccc([N+](=O)[O-])cc1>>O=C(Nc1cccnc1)Nc1cccc(OCCCN2CCOCC2)c1,,ClC(Cl)Cl,,,,val
US20120165352A1,C=O.COC(=O)C1CCCN1>>COC(=O)C1CCCN1C,,CO,,[BH3-]C#N.[Na+],,val
US06432993B1,CN(C(=O)OC(C)(C)C)c1cc(Cl)ccc1[N+](=O)[O-].Cc1ccc(S)cc1>>Cc1ccc(Sc2ccc([N+](=O)[O-])c(N(C)C(=O)OC(C)(C)C)c2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20080261978A1,NCc1ccc(S(=O)(=O)N(Cc2ccccc2)Cc2ccccc2)cc1.O=Cc1ccncc1>>O=S(=O)(c1ccc(CNCc2ccncc2)cc1)N(Cc1ccccc1)Cc1ccccc1,,CO,,[BH4-].[Na+],,val
US20130065901A1,CC(=O)CCl.NC(=S)Nc1ncc(Br)cc1Sc1ccccc1>>Cc1csc(Nc2ncc(Br)cc2Sc2ccccc2)n1,,O,,CCN(CC)CC,CCO,val
US20100029722A1,C#Cc1nc(C)c(C(=O)OCC)s1.[N-]=[N+]=NCc1ccccc1>>CCOC(=O)c1sc(-c2cn(Cc3ccccc3)nn2)nc1C,[Cu]I,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20070149610A1,CC(C)=CCC[C@@]1(C)C=Cc2c(O)c3c(c(CC=C(C)C)c2O1)O[C@]12C(=C[C@@H]4CC1C(C)(C)OC2(C/C=C(\CO)C(=O)O)C4=O)C3=O>>CC(C)=CCC[C@]1(C)C=Cc2c(O)c3c(c(CC=C(C)C)c2O1)O[C@]12C(=C[C@@H]4CC1C(C)(C)OC2(C/C=C(\C)C(=O)O)C4=O)C3=O,,ClC(Cl)Cl,,,,val
US20090233920A1,CC1(C)Oc2ccc([N+](=O)[O-])cc2NC1=O.COCCCOS(=O)(=O)c1ccc(C)cc1>>COCCCN1C(=O)C(C)(C)Oc2ccc([N+](=O)[O-])cc21,,CN(C)C=O,,O,[H-].[Na+],val
US20100280001A1,CCCCc1nc2c(N)nc3ccccc3c2n1CCCNC1CCN(C)CC1.COC(=O)Cc1cccc(C=O)c1>>CCCCc1nc2c(N)nc3ccccc3c2n1CCCN(Cc1cccc(CC(=O)OC)c1)C1CCN(C)CC1,,CN1CCCC1=O,CO,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04975431,Cc1cc2c(nc1Br)CCCCC2.O=Cc1cccs1>>Cc1cc2c(nc1C(O)c1cccs1)CCCCC2,,CCCCCC,Cc1ccccc1,O,[Li]CCCC,val
US20120040954A1,CC(=O)Cl.COc1cc(OC)c2c(=O)[nH]c(-c3ccc(C4CCNCC4)cc3)nc2c1>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(C4CCN(C(C)=O)CC4)cc3)nc2c1,,ClCCl,,CCN(CC)CC,,val
US20150336944A1,Cn1cc(-c2cc(-c3cnn(C)c3)c(O)cn2)cn1.N#Cc1cc(S(=O)(=O)Nc2nccs2)ccc1F>>Cn1cc(-c2cc(-c3cnn(C)c3)c(Oc3ccc(S(=O)(=O)Nc4nccs4)cc3C#N)cn2)cn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150057271A1,COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(c2)OC(C)CN3)cc1.N#Cc1cc(C(F)(F)F)ccc1F>>COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(c2)OC(C)CN3c2ccc(C(F)(F)F)cc2C#N)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120028961A1,CCO.Cl.N#CCc1ccccc1>>CCOC(=N)Cc1ccccc1.Cl,,C1COCCO1,,,,val
US20020107261A1,CC(C)OCCl.CCCC[SnH](CCCC)CCCC>>CCCC[Sn](CCCC)(CCCC)COC(C)C,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20040122050A1,CCOC(=O)C(CCC1CCC(c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1)S(C)(=O)=O>>CS(=O)(=O)C(CCC1CCC(c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1)C(=O)O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20130281433A1,CC(N=[N+]=[N-])c1cc(Br)ccn1>>CC(N)c1cc(Br)ccn1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20020025948A1,CCC1(c2cccc(N)c2)C2C(=O)N(Cc3ccccc3)C(=O)C21.CS(=O)(=O)Cl>>CCC1(c2cccc(NS(C)(=O)=O)c2)C2C(=O)N(Cc3ccccc3)C(=O)C21,,ClCCl,,c1ccncc1,,val
US20010012905A1,CC(=O)c1ccc(C(=O)OC(=O)c2ccc(C(C)=O)c3ccccc23)c2ccccc12.Nc1ccccc1>>CC(=O)c1ccc(C(O)=Nc2ccccc2)c2ccccc12,,CC(=O)O,,,,val
US20030236287A1,COc1cc(OC)c(OC)cc1N.O=C(Cl)Cl>>COc1cc(OC)c(OC)cc1N=C=O,,CCOC(C)=O,,,,val
US20120108583A1,CC1(C)Cc2c(c(C(=O)O)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1.Nc1cc(C2CC2)ccc1F>>CC1(C)Cc2c(c(C(=O)Nc3cc(C4CC4)ccc3F)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1,,C1CCOC1,,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US20080306082A1,COc1cccc2cc(-c3ccnc(NCCCN4CCN(C)CC4)n3)sc12>>CN1CCN(CCCNc2nccc(-c3cc4cccc(O)c4s3)n2)CC1,,ClCCl,,BrB(Br)Br,,val
US20090137568A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC[C@@H]1CN(Cc2ccccc2)CC[C@@H]1O>>CC(C)(C)OC(=O)NC[C@@H]1CN(Cc2ccccc2)CC[C@@H]1O,,ClC(Cl)Cl,,O,O=C([O-])O.[Na+],val
US04268438,CCCCNCCCC.Nc1nnc(Cl)s1>>CCCCN(CCCC)c1nnc(N)s1,,CCO,,CCN(CC)CC,,val
US20100204272A1,CCCO[C@@H]1CC[C@@H](N2CCC(Nc3cc(S(C)(=O)=O)c(C)cc3O)CC2)CC1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCO[C@@H]1CC[C@@H](N2CCC(n3c(=O)oc4cc(C)c(S(C)(=O)=O)cc43)CC2)CC1.Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05532400,C[Si](C)(C)CCl.Cc1cc(C=O)cc(C)c1O>>Cc1cc(C(O)C[Si](C)(C)C)cc(C)c1O,,CCOCC,,[Mg],[Cl-].[NH4+],val
US04143049,ClCl.c1ccc(N=NC(=NNc2ccccc2)c2ccccc2)cc1>>Cl.[Cl-].c1ccc(C2=NN(c3ccccc3)N(c3ccccc3)[NH2+]2)cc1,,CCO,,[Na+].[OH-],,val
US20130336920A1,CN(CC=O)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)N[C@H]3CCCc4ccccc43)ccn2)c1.O=C1CNCCN1>>CN(CCN1CCNC(=O)C1)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)N[C@H]3CCCc4ccccc43)ccn2)c1,,CCO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20070249670A1,COC(=O)C(NC(=O)c1cc2ccccc2cc1N)C1CCC(NC(=O)OC(C)(C)C)CC1.Cc1cc(C)c(N=C=O)c(C)c1>>COC(=O)C(NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C)C1CCC(NC(=O)OC(C)(C)C)CC1,,c1ccncc1,,,,val
US20060287344A1,C[C@@H](c1ccccc1)N(C(=O)C(F)(F)F)C1CCC2(CC1)OCCO2>>C[C@@H](c1ccccc1)N(C(=O)C(F)(F)F)C1CCC(=O)CC1,,C1CCOC1,,Cl,,val
US20080269210A1,C=O.OC1(c2cc3nc(Cl)nc(N4CCOCC4)c3s2)CCNCC1>>CN1CCC(O)(c2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1,,CN(C)C=O,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US06429221B1,CCOC(=O)N1C(=O)c2ccccc2C1=O.COc1ccc(CC(C)N)cc1OC>>COc1ccc(CC(C)N2C(=O)c3ccccc3C2=O)cc1OC,,CC#N,O,O=C([O-])[O-].[Na+].[Na+],,val
US20070049632A1,CC1(C)[C@@H]2CC[C@@]1(C)c1[nH]n(-c3ccc(F)cc3F)c(=O)c12.CCOC(=O)CI>>CCOC(=O)Cn1c2c(c(=O)n1-c1ccc(F)cc1F)[C@H]1CC[C@]2(C)C1(C)C,,CN(C)C=O,,,,val
US20090069303A1,O=c1[nH]nc(Cc2cc([N+](=O)[O-])cs2)c2ccccc12>>Nc1csc(Cc2n[nH]c(=O)c3ccccc23)c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20090181929A1,CCNCC1CCCC1.O=Cc1cccnc1Cl>>CCN(CC1CCCC1)c1ncccc1C=O,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20100105906A1,O=c1[nH]c2ccccc2n(C2CC2)c1=O>>c1ccc2c(c1)NCCN2C1CC1,,C1CCOC1,,B,,val
US20040152698A1,COc1ccncc1C.O=[N+]([O-])O>>COc1c(C)cncc1[N+](=O)[O-],,O=S(=O)(O)O,,O=C([O-])[O-].[K+].[K+],,val
US20140213586A1,O=C(O)Cc1cccnc1.c1ccc2[nH]ccc2c1>>O=C(Cc1cccnc1)c1c[nH]c2ccccc12,,CC(=O)OC(C)=O,,O=C([O-])O.[Na+],,val
US20150210705A1,CC=CC(=O)Cl.c1ccc(-c2cnc3[nH]ccc3c2)cc1>>CC=CC(=O)c1c[nH]c2ncc(-c3ccccc3)cc12,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100056556A1,CC1(C)CNC(=O)CC1=O.c1ccc(C(=NNc2cccc3cnccc23)c2ccccc2)cc1>>CC1(C)CNC(=O)c2c1[nH]c1c2ccc2cnccc21,O,CC(=O)O,CO,Cl,[Na+].[OH-],val
US20060247250A1,CN(C)CCNS(=O)(=O)c1cccc(Nc2ncc(N)cn2)c1.Cc1cccc(C)c1C(=O)Cl>>Cc1cccc(C)c1C(=O)Nc1cnc(Nc2cccc(S(=O)(=O)NCCN(C)C)c2)nc1,,Cc1ccccc1,ClCCl,,,val
US20100190831A1,CCOC(=O)COc1ccc(OC(C)=O)cc1C>>CCOC(=O)COc1ccc(O)cc1C,,CO,,C[O-].[Na+],,val
US20140303384A1,CC(C)(C)OC(=O)N1CCCC1c1ccc(-c2ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc2)cc1>>O=C(N[C@H](CF)[C@H](O)c1ccc(-c2ccc(C3CCCN3)cc2)cc1)C(Cl)Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090247517A1,CCNC.O=c1c2nc(Br)n(-c3ccccc3)c2nc(-c2ccc(C(F)(F)F)cc2)n1-c1ccc(Cl)cc1>>CCN(C)c1nc2c(=O)n(-c3ccc(Cl)cc3)c(-c3ccc(C(F)(F)F)cc3)nc2n1-c1ccccc1,,ClCCl,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20040010033A1,Cc1cc2c(cc1Cc1ccc(C(=O)O)o1)C(C)(C)CCC2(C)C.O=S(Cl)Cl>>Cc1cc2c(cc1Cc1ccc(C(=O)Cl)o1)C(C)(C)CCC2(C)C,,ClCCl,,,,val
US20040171075A1,COC(=O)C=Cc1cccc(N)c1>>COC(=O)CCc1cccc(N)c1,[Pd],CCO,,,,val
US20110190310A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccc(N)cc1Cl>>COC(=O)c1ccc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1Cl,CN(C)c1ccncc1,CC#N,,,,val
US20090247517A1,CI.O=c1c2cnn(-c3ccccc3)c2nc(-c2ccc(-c3cc[nH]n3)cc2)n1-c1ccc(Cl)cc1>>Cn1ccc(-c2ccc(-c3nc4c(cnn4-c4ccccc4)c(=O)n3-c3ccc(Cl)cc3)cc2)n1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20160039801A1,CCOC(=O)C1=C(c2cccnc2OC)CCC1>>COc1ncccc1C1=C(CO)CCC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04521413,Brc1cccnc1.NCCO>>OCCNc1cccnc1,,O,,,,val
US20100160369A1,Cc1cc(CCC(=O)OC(C)(C)C)c(Cl)cc1-c1noc(-c2cn3cc(C(F)(F)F)cc(Br)c3n2)n1>>Cc1cc(CCC(=O)O)c(Cl)cc1-c1noc(-c2cn3cc(C(F)(F)F)cc(Br)c3n2)n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20110077279A1,CCCCc1nc(Cl)c(C(=O)OC(C)OC(=O)O[C@@H]2CO[C@@H]3[C@H](OC(=O)CCCC(CO[N+](=O)[O-])O[N+](=O)[O-])CO[C@H]23)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCCCc1nc(Cl)c(C(=O)OC(C)OC(=O)O[C@@H]2CO[C@@H]3[C@H](OC(=O)CCCC(CO[N+](=O)[O-])O[N+](=O)[O-])CO[C@H]23)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,CO,,,,val
US20070112005A1,CCOC(CBr)OCC.Sc1ccccc1Cl>>CCOC(CSc1ccccc1Cl)OCC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120232112A1,CC(C)(C)C(=O)CBr.CCOC(=O)c1cc(N)n(-c2ccccc2)n1>>CCOC(=O)c1cc(NCC(=O)C(C)(C)C)n(-c2ccccc2)n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20010034449A1,CC(C)(O)CON1C(C)(C)CC(=O)CC1(C)C.CCCCN>>CCCCNC1CC(C)(C)N(OCC(C)(C)O)C(C)(C)C1,[Pt],,,,,val
US20040102634A1,CCOC(=O)[C@H](Cc1cccc(OC[C@H](O)COc2ccc(Cl)cc2Cl)c1)OC(C)C>>CC(C)O[C@@H](Cc1cccc(OC[C@H](O)COc2ccc(Cl)cc2Cl)c1)C(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20120149910A1,Cc1cc(C(=O)O)ccc1C#N.O=C(Cl)C(=O)Cl>>Cc1cc(C(=O)Cl)ccc1C#N,CN(C)C=O,ClCCl,,,,val
US20070179165A1,CCCC(=O)Cc1cccc(-c2c(C)cc(C)cc2C)n1.CCOC=C(C(=O)OCC)C(=O)OCC>>CCCC(=O)C(c1cccc(-c2c(C)cc(C)cc2C)n1)C(OCC)C(C(=O)OCC)C(=O)OCC,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20080064715A1,OC(c1ccccc1)c1cc2ccnc(Cl)c2[nH]1>>OC(c1ccccc1)c1cc2ccncc2[nH]1,[Pd],CO,,O=C[O-].[NH4+],,val
US20090186911A1,CC(C)N.CSc1cncc(COc2cc(N=CN(C)C)c(C#N)cc2Br)c1>>CSc1cncc(COc2cc3ncnc(NC(C)C)c3cc2Br)c1,,CO,,ClCCl,,val
US06410534B1,N#Cc1ccc(Cn2cncc2CO)cc1F.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>N#Cc1ccc(Cn2cncc2CN=[N+]=[N-])cc1F,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20100004441A1,NC1CC1.O=C(O)c1ccc(-c2csc(NC(=O)[C@@H]3CCCN3C(=O)OCc3ccccc3)n2)nc1>>O=C(NC1CC1)c1ccc(-c2csc(NC(=O)[C@@H]3CCCN3C(=O)OCc3ccccc3)n2)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150299120A1,COCOCC1CCCC12C(=O)N(c1ccc(C#N)c(Cl)c1C)C(=O)N2C>>Cc1c(N2C(=O)N(C)C3(CCCC3CO)C2=O)ccc(C#N)c1Cl,,CO,,Cl,,val
US20140170207A1,CCCCCCCCCCC(C)O.NC(Cc1ccccc1)C(=O)O>>CCCCCCCCCCCCOC(=O)C(N)Cc1ccccc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20030162806A1,CC(C)C(=O)Cl.CCOCc1nc2c(N)nc(C)c(C)c2n1CCC1CCNCC1>>CCOCc1nc2c(N)nc(C)c(C)c2n1CCC1CCN(C(=O)C(C)C)CC1,,ClC(Cl)Cl,ClCCl,,,val
US20080293782A1,O=C1CN(c2cc(-c3ccoc3)ccc2OCc2ccccc2)S(=O)(=O)N1>>O=C1CN(c2cc(C3CCOC3)ccc2O)S(=O)(=O)N1,[Pd],,,,,val
US20100093730A1,C=CC#N.CCOC(=O)C(c1ccc(F)cc1)c1ccc(F)cc1>>CCOC(=O)C(CCC#N)(c1ccc(F)cc1)c1ccc(F)cc1,,C1COCCO1,,C,C[O-].[Na+],val
US20100113458A1,COc1ccc(CN(c2cc(Cl)nn3c(C#N)cnc23)C2CC2)cc1.COc1ccc(CNCCN2CCOCC2)cc1>>COc1ccc(CN(CCN2CCOCC2)c2cc(Cl)nn3c(C#N)cnc23)cc1,,CO,,,,val
US20110118236A1,COC(=O)c1n[nH]c2c1CCCC2.O=C(c1ccc(CBr)cc1)N1CCCC1>>COC(=O)c1nn(Cc2ccc(C(=O)N3CCCC3)cc2)c2c1CCCC2,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160200714A1,CS(=O)(=O)Cl.O=C(N[C@H]1CC[C@H](O)C1)c1ccc(-c2ccccc2)cc1>>CS(=O)(=O)O[C@H]1CC[C@H](NC(=O)c2ccc(-c3ccccc3)cc2)C1,,CC(C)=O,,CCN(CC)CC,,val
US20060069144A1,CC(=O)c1cccc2ccccc12.Ic1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CC(O)(c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)c1cccc2ccccc12,,ClCCl,,CC[Mg]Br,,val
US20150210675A1,CCCCCCCCc1ccc(-c2noc([C@@H]3C[C@@H](O)CN3C(=O)OC(C)(C)C)n2)cc1.O=C(O)c1ccccc1>>CCCCCCCCc1ccc(-c2noc([C@@H]3C[C@H](OC(=O)c4ccccc4)CN3C(=O)OC(C)(C)C)n2)cc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090036450A1,CC(N)=O.CCOC(=O)C(Cl)C(=O)CCc1ccccc1>>CCOC(=O)c1oc(C)nc1CCc1ccccc1,,O,,,,val
US20110269737A1,Cn1ccc2cccc(C=O)c21>>Cn1ccc2cccc(CO)c21,,CCO,,[BH4-].[Na+],,val
US04954498,O=C1CCc2cc(NC(=O)c3ccncc3)c([N+](=O)[O-])cc2N1>>O=C1CCc2cc3[nH]c(-c4ccncc4)nc3cc2N1,[Pd],CO,,,,val
US20030092720A1,CC(=O)Nc1cc(C)c(F)cn1>>Cc1cc(N)ncc1F,,CCO,,Cl,,val
US05321136,Cc1cc(C)c2c(C(=O)O)c3c(C)cc(C)cc3nc2c1.Oc1ccccc1>>Cc1cc(C)c2c(C(=O)Oc3ccccc3)c3c(C)cc(C)cc3nc2c1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20120329780A1,CC(C)(C)OC(=O)N[C@@H]1CCCC[C@H]1N.COc1ccc(Cn2cc3nc(-c4ccsc4)nc(Cl)c3n2)cc1>>N[C@@H]1CCCC[C@H]1Nc1nc(-c2ccsc2)nc2cn[nH]c12,C1COCCO1,CO,,Cl,,val
US20140256723A1,CCCCC[C@@H](C)N=C=O.CCOC(=O)[C@@](O)(Cc1ccc(F)cc1)c1nc2cc(NS(C)(=O)=O)ccc2[nH]1>>CCCCC[C@@H](C)N1C(=O)O[C@](Cc2ccc(F)cc2)(c2nc3cc(NS(C)(=O)=O)ccc3[nH]2)C1=O,,C1CCOC1,,[Na+].[OH-],,val
US20040044057A1,CC(C)C(O)Cn1ccnc1.O=C1CCCc2c1ccc(O)c2CS(=O)(=O)c1ccccc1>>CC(C)C(Cn1ccnc1)Oc1ccc2c(c1CS(=O)(=O)c1ccccc1)CCCC2=O,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040063680A1,CN(C)S(=O)(=O)NCC(C)(F)c1ccc(I)cc1.Nc1cccc(B(O)O)c1>>CN(C)S(=O)(=O)NCC(C)(F)c1ccc(-c2cccc(N)c2)cc1,,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20050215574A1,COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC(C)=O>>COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1O,,CO,,Cl,N,val
US20040254214A1,CCOc1cc([C@@H](CS(C)(=O)=O)N2Cc3c(Cl)ccc(NC(=O)CCl)c3C2=O)ccc1OC.CNC>>CCOc1cc([C@@H](CS(C)(=O)=O)N2Cc3c(Cl)ccc(NC(=O)CN(C)C)c3C2=O)ccc1OC,,CC#N,CCOCC,Cl,,val
US20020115700A1,O=C1CSC(=O)N1.O=Cc1cn(-c2ccc(Cl)c(Cl)c2)c2ccc(OCc3ccccc3)cc12>>O=C1NC(=O)C(=Cc2cn(-c3ccc(Cl)c(Cl)c3)c3ccc(OCc4ccccc4)cc23)S1,,CCO,,C1CCNCC1,,val
US20100063038A1,CC1(C)C(=O)N(Br)C(=O)N1Br.Nc1ncnn2c(CN3CCCOCC3)ccc12>>Nc1ncnn2c(CN3CCCOCC3)cc(Br)c12,,ClC(Cl)Cl,,,,val
US20100160389A1,Cc1c([N+](=O)[O-])cc(OCCO[Si](C)(C)C(C)(C)C)c(F)c1F>>Cc1c(N)cc(OCCO[Si](C)(C)C(C)(C)C)c(F)c1F,[Pd],CCO,,,,val
US20080139802A1,CC1(F)C(OC(=O)c2ccccc2)C(COC(=O)c2ccccc2)OC1n1ccc(NC(=O)c2ccccc2)nc1=O>>CC1(F)C(O)C(CO)OC1n1ccc(N)nc1=O,,CO,,C[O-].[Na+],,val
US04050921,O=C(OO)c1cccc(Cl)c1.[O-][n+]1ccccc1SCc1ccccc1F>>O=S(Cc1ccccc1F)c1cccc[n+]1[O-],,ClC(Cl)Cl,,,,val
US20070179165A1,CCCC(CCC)n1ccc(=O)c2c(Br)cccc21.Cc1ccc(B(O)O)c(C)c1>>CCCC(CCC)n1ccc(=O)c2c(-c3ccc(C)cc3C)cccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20060258659A1,CCCCC=O.Nn1cccc1>>CCCC/C=N/n1cccc1,,CCO,,,,val
US20040162285A1,N#CCOc1ccc2c(c1)S(=O)(=O)N=C(c1c(O)c3ccccc3n(NCC3CC3)c1=O)N2>>NCCOc1ccc2c(c1)S(=O)(=O)N=C(c1c(O)c3ccccc3n(NCC3CC3)c1=O)N2,,C1CCOC1,O,[BH4-].[Li+],,val
US20060189606A1,C1COCCN1.C=CS(=O)(=O)Nc1ccc(-c2c(C#N)c3ccc(OC)cc3n2CC)cc1>>CCn1c(-c2ccc(NS(=O)(=O)CCN3CCOCC3)cc2)c(C#N)c2ccc(OC)cc21,,CC#N,,,,val
US20160159752A1,CC(C)(C)OC(=O)N1C[C@H](CO[Si](C)(C)C(C)(C)C)N(Cc2ccccc2)C2(CC2)C1>>CC(C)(C)OC(=O)N1C[C@H](CO)N(Cc2ccccc2)C2(CC2)C1,,C1CCOC1,ClCCl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20060235030A1,CC(C)(C)NCCCN.CCCNC(=O)c1ccc(C)c(-c2nc(S(C)=O)nc3c2CNC(=O)N3c2c(F)cccc2F)c1>>CCCNC(=O)c1ccc(C)c(-c2nc(NCCCNC(C)(C)C)nc3c2CNC(=O)N3c2c(F)cccc2F)c1,,ClCCl,,,,val
US20140213571A1,CCN(CC)S(F)(F)F.OC1COc2ccc(Br)cc2-c2cc3ccccc3n2C1>>FC1COc2ccc(Br)cc2-c2cc3ccccc3n2C1,,ClCCl,O,,,val
US20130267494A1,CC(=O)OCC(=O)Cl.CC(C)(C)OC(=O)N1CCO[C@@H](CN)[C@H](c2ccc(Cl)c(Cl)c2)C1>>Cl.O=C(CO)NC[C@@H]1OCCNC[C@H]1c1ccc(Cl)c(Cl)c1,,C1CCOC1,,CCN(CC)CC,O,val
US20060217379A1,CCOC(=O)C1CCN(c2cc(Oc3cc(C(F)(F)F)nn3C)ncn2)CC1.O=C1CCC(=O)N1Br>>CCOC(=O)C1CCN(c2ncnc(Oc3cc(C(F)(F)F)nn3C)c2Br)CC1,,CN(C)C=O,,,,val
US20110184206A1,O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].[Al+3].[Rb+]>>O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].[Al+3].[Rb+],,O,,,,val
US20070010573A1,CC(C)C[C@H](N)CO.O=S1(=O)CCCO1>>CC(C)C[C@@H](CO)NCCCS(=O)(=O)O,,C1CCOC1,,,,val
US04188328,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CC(CO)CCCC1(C)OCCO1>>CC(CCCC1(C)OCCO1)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,CN(C)C=O,,c1c[nH]cn1,,val
US20020031816A1,Nc1ccccc1.O=C(Cl)c1cccc([N+](=O)[O-])c1>>O=C(Nc1ccccc1)c1cccc([N+](=O)[O-])c1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US04587240,CO.O=[N+]([O-])c1cc[n+]([O-])c(Cl)c1>>COc1cc[n+]([O-])c(Cl)c1,,CO,,[Na],C[O-].[Na+],val
US20020052400A1,ICCC1=COc2ccccc2O1.O=C1NC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1CCC1=COc2ccccc2O1,,CN(C)C=O,,[K],,val
US20050209284A1,CN(C)CCCl.Cc1ncc(-c2ccc(C(=O)Nc3nc4cc(O)ccc4n3CC(C)(C)O)s2)o1>>Cc1ncc(-c2ccc(C(=O)Nc3nc4cc(OCCN(C)C)ccc4n3CC(C)(C)O)s2)o1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20140235591A1,CO.NC1(C(=O)O)CC[C@H](c2ccc(Br)cc2)C1.O=S(Cl)Cl>>COC(=O)[C@@]1(N)CC[C@H](c2ccc(Br)cc2)C1.Cl,,CCOC(C)=O,O,,,val
US20050113430A1,CC(=O)OC(C)=O.COc1ccc(O)c(C=O)c1.Nc1cc(Cl)ccc1S>>COc1ccc(O)c(C2Sc3ccc(Cl)cc3N2C(C)=O)c1,,CO,,,,val
US20120010414A1,Cn1cc(C(=O)O)nc1Br.FC(F)(F)Oc1cccc(CNC2CCOCC2)c1>>Cn1cc(C(=O)N(Cc2cccc(OC(F)(F)F)c2)C2CCOCC2)nc1Br,,CC#N,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070244132A1,COc1ccc(C(=O)Cl)cc1OC.Fc1cccc(COc2ccc(Nc3ncnc4cc[nH]c34)cc2Cl)c1>>COc1ccc(C(=O)n2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c32)cc1OC,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120065196A1,CC1CNCCC1C(=O)N1CCCC1.O=C(NCCNC(=O)c1cn(-c2ccccc2)nc1C(F)(F)F)Oc1ccccc1>>CC1CN(C(=O)NCCNC(=O)c2cn(-c3ccccc3)nc2C(F)(F)F)CCC1C(=O)N1CCCC1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060019994A1,Cc1cc(COC2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc2n1>>Cc1cc(COC2CCNCC2)c2ccccc2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070082899A1,CC(=O)OCC(=O)Cl.CN(c1ccc2c(c1)nc(C(C)(C)C)n2CC1CCOCC1)S(=O)(=O)c1ccc(N)cc1>>CC(=O)OCC(=O)Nc1ccc(S(=O)(=O)N(C)c2ccc3c(c2)nc(C(C)(C)C)n3CC2CCOCC2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20030232869A1,CN1CCNCC1.O=C(NOCC1CC1)c1cc2c(ncn2CCCCCl)c(F)c1Nc1ccc(Br)cc1Cl>>CN1CCN(CCCCn2cnc3c(F)c(Nc4ccc(Br)cc4Cl)c(C(=O)NOCC4CC4)cc32)CC1,,CCOC(C)=O,,[I-].[Na+],,val
US20040106653A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(Cc1ccc(I)cc1)NC[C@H](O)c1cccc(Cl)c1>>CC(C)(C)OC(=O)N(CCc1ccc(I)cc1)C[C@H](O)c1cccc(Cl)c1,,C1CCOC1,CCOC(C)=O,Cl,[Na+].[OH-],val
US05254685,C=O.CCOC(=O)c1cn2c3c(c(F)c(F)cc3c1=O)CCN2>>CCOC(=O)c1cn2c3c(c(F)c(F)cc3c1=O)CCN2CO,,CC(=O)O,,,,val
US04556739,CCOC(=O)CCCBr.COc1cc(N)c(C(C)=O)cc1OC>>CCOC(=O)CCCNc1cc(OC)c(OC)cc1C(C)=O,,CCN(CC)CC,ClC(Cl)Cl,O=C([O-])O.[Na+],,val
US20160083343A1,Cc1ncccc1C(=O)N1CCCC[C@H]1CO.O=Cc1c(O)cccc1O>>Cc1ncccc1C(=O)N1CCCC[C@H]1COc1cccc(O)c1C=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130158009A1,CC(C)(C)OC(=O)N1CCC(N2CC[C@H](Nc3ccc(S(C)(=O)=O)cc3F)C2=O)C(C)(C)C1>>CC1(C)CNCCC1N1CC[C@H](Nc2ccc(S(C)(=O)=O)cc2F)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060205790A1,CC1(C)OCc2cc([C@@H]3CN(CCc4ccc5c(c4)O[C@H](CO)CO5)C(=O)O3)ccc2O1.Clc1cccc(Cl)c1CBr>>CC1(C)OCc2cc([C@@H]3CN(CCc4ccc5c(c4)O[C@H](COCc4c(Cl)cccc4Cl)CO5)C(=O)O3)ccc2O1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US09365579B2,C1CCOC1.C1COCCO1.ClCCl.O=C(n1ccnc1)n1ccnc1.c1ccncc1>>CC1CCCCC1C(=O)Cl,,CN(C)C=O,c1ccncc1,,,val
US06372736B1,O=C(O)[C@@H]1CCCCN1c1nc2ccccc2o1.O[C@@H]1CCCN(Cc2ccccn2)C1>>O=C(O[C@H]1CCCN(Cc2ccccn2)C1)[C@@H]1CCCCN1c1nc2ccccc2o1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040006116A1,CCOC(=O)c1ccccc1CBr.Cc1oc(-c2ccccc2)nc1CCOc1ccc(NC(=O)OC(C)(C)C)cc1>>CCOC(=O)c1ccccc1CN(C(=O)OC(C)(C)C)c1ccc(OCCc2nc(-c3ccccc3)oc2C)cc1,,CS(C)=O,,[K+].[OH-],,val
US20070010542A1,CC1(C)OC[C@@H](CO)O1.Cc1c(Cl)cc[n+]([O-])c1C>>Cc1c(OC[C@@H]2COC(C)(C)O2)cc[n+]([O-])c1C,,CS(C)=O,,[H-].[Na+],,val
US20080319005A1,Nc1cccc(C(F)(F)F)c1.O=C(O)Cc1ccc(-n2cnc3cnccc32)cc1>>O=C(Cc1ccc(-n2cnc3cnccc32)cc1)Nc1cccc(C(F)(F)F)c1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120088748A1,CC(C)(C)OC(=O)N1CCOC(CI)C(c2ccc(Cl)c(Cl)c2)C1.COc1ccc(CN)cc1>>COc1ccc(CNCC2OCCN(C(=O)OC(C)(C)C)CC2c2ccc(Cl)c(Cl)c2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060252797A1,Cc1ccccc1.Nc1ccccc1.O=C1CCN(Cc2ccccc2)CC1>>CCCCC1(Nc2ccccc2)CCN(Cc2ccccc2)CC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20070149533A1,CC(C)(C)c1cccc(NC(=O)C2CCc3ccc(Oc4ccnc(N)c4)cc3C2)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)c1cccc(NC(=O)C2CCc3ccc(Oc4ccnc(N=C=O)c4)cc3C2)c1,,C1CCOC1,,,,val
US20120208827A1,CC1(C)OB(c2ccc3occc3c2)OC1(C)C.N#Cc1cccc2c1nc(-c1ccc(Br)cc1)n2C[C@@H]1CCN(C(=O)C2CC2)C1>>N#Cc1cccc2c1nc(-c1ccc(-c3ccc4occc4c3)cc1)n2C[C@@H]1CCN(C(=O)C2CC2)C1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US05165957,CCO.O=C(c1ccc2c(c1)C(=O)OC2=O)c1ccc2c(c1)C(=O)OC2=O>>O=C(c1ccccc1)c1ccccc1,,CN1CCCC1=O,,,,val
US20070054916A1,C1CCNC1.CC(C)(C)c1ccc(NC(=O)CCl)c([N+](=O)[O-])c1>>CC(C)(C)c1ccc(NC(=O)CN2CCCC2)c([N+](=O)[O-])c1,,CCOC(C)=O,,C1CCOC1,CCN(CC)CC,val
US20080200466A1,CC(Oc1ccc(Cl)cc1Cc1cc(Cl)ccc1OCC(=O)OCc1ccccc1)C(=O)OC(C)(C)C>>CC(Oc1ccc(Cl)cc1Cc1cc(Cl)ccc1OCC(=O)OCc1ccccc1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050197386A1,CCCCCC[C@@H]1C(=O)O[C@H]1CCCCCOCc1ccccc1>>CCCCCC[C@@H]1C(=O)O[C@H]1CCCCCO,[Pd],CCOC(C)=O,,[H][H],,val
US20040058978A1,CCOC(=C1C(=O)N(C(C)=O)c2ccc([N+](=O)[O-])cc21)c1ccccc1.Nc1ccc(CCN2CCCCC2)cc1>>O=C1Nc2ccc([N+](=O)[O-])cc2/C1=C(/Nc1ccc(CCN2CCCCC2)cc1)c1ccccc1,,CN(C)C=O,CO,[Na+].[OH-],,val
US04621095,ClCC1(CCl)CO1.Oc1ccc(Cl)cc1>>ClCC1(COc2ccc(Cl)cc2)CO1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040248941A1,CCOC(=O)OC(C)n1c(SCc2nccc(OCC(F)(F)F)c2C)nc2ccccc21.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)OC(C)n1c(S(=O)Cc2nccc(OCC(F)(F)F)c2C)nc2ccccc21,,ClCCl,,,,val
US05252569,COc1ccccc1N1CCNCC1.ClCC1CO1>>COc1ccccc1N1CCN(CC(O)CCl)CC1,,CC#N,,,,val
US05240938,COC(=O)c1ccc(O[Si](C)(C)C(C)(C)C)c(Cl)c1>>CC(C)(C)[Si](C)(C)Oc1ccc(CO)cc1Cl,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070054928A1,O=C(NCCc1ccccc1)C(=O)Nc1ccc(OCc2ccccc2)c(F)c1>>O=C(NCCc1ccccc1)C(=O)Nc1ccc(O)c(F)c1,,CC(=O)O,,Br,,val
US20090030013A1,Cc1ccc2c(N3CCN(C(=O)OC(C)(C)C)CC3)cccc2n1>>CC1CCc2c(cccc2N2CCN(C(=O)OC(C)(C)C)CC2)N1,,CO,,[BH4-].[Na+],,val
US20020193367A1,CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccnn3C)c2)cc1C(F)(F)F>>CN(C)c1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3ccnn3C)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100305102A1,CC(C)[C@@H](N)CO.Clc1nc(Cl)c2c(n1)CCS2>>CC(C)[C@H](CO)Nc1nc(Cl)nc2c1SCC2,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20130131017A1,CCOC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)c2cccn12>>O=C(O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)c2cccn12,,CO,O,Cl,[Na+].[OH-],val
US20080167303A1,O=S1(=O)N(CCCBr)c2ccccc2N1c1ccc(Cl)cc1F.OCCBr>>O=S1(=O)N(CCBr)c2ccccc2N1c1ccc(Cl)cc1F,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04670540,CCOC(=O)CNC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)CC>>CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)O,,CO,,[Na+].[OH-],,val
US20060287286A1,NS(=O)(=O)c1cccc(CCCCOCCCCCCN(Cc2ccccc2)C[C@H](O)c2ccc(O)c(CO)c2)c1>>NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1,[Pd],,,,,val
US20130324528A1,CC(=O)N(C(C)=O)c1c(Br)ccnc1C>>CC(=O)Nc1c(Br)ccnc1C,,CO,,Cl,[Na+].[OH-],val
US20050153942A1,COC(=O)c1nc(C(C)=O)c(ON=C(C)C)c(F)c1Nc1ccccc1F>>COC(=O)c1nc2c(C)noc2c(F)c1Nc1ccccc1F,,CCOC(C)=O,CO,,,val
US04925879,CCOC(=O)CBr.N#CC1(c2ccc(Cl)cc2)CCC1>>CCOC(=O)C=C(N)C1(c2ccc(Cl)cc2)CCC1,[Zn],C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20090186879A1,COC(=O)c1cccc([N+](=O)[O-])c1NC(=O)OC(C)(C)C>>COC(=O)c1cccc(N)c1NC(=O)OC(C)(C)C,[Pd],CO,,,,val
US20130204004A1,COc1cccc(C(=O)CBr)c1.OCc1ccc(O)cc1>>COc1cccc(C(=O)COc2ccc(CO)cc2)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080306125A1,CC(C)(C)OC(=O)c1cc2ccc(O)cc2o1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)c1cc2ccc(OS(=O)(=O)C(F)(F)F)cc2o1,,CCN(CC)CC,ClCCl,,,val
US05134128,CC(=O)OC(C)=O.CCCC[Sn](CCCC)(CCCC)OCCCc1ccccn1.C[Si](C)(C)c1cc(C=O)co1>>CC(=O)OC(COCCCc1ccccn1)c1coc([Si](C)(C)C)c1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20130116246A1,CC1(C)COC(c2ccc(C(C)(C)C)cc2)=N1.CN(C)C=O>>CC1(C)COC(c2ccc(C(C)(C)C)cc2C=O)=N1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US04769501,Cc1cc(CO)c(O)c(CO)c1>>Cc1cc(C)c(O)c(C)c1,,CO,,[H][H],,val
US20070004710A1,BrP(Br)Br.COc1ccc2nccc(O)c2c1>>COc1ccc2nccc(Br)c2c1,,CN(C)C=O,,,,val
US04448962,CC(=O)O.O=C(O)c1cn(CCO)c2cc(N3CCNCC3)c(F)cc2c1=O>>CC(=O)N1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3CCO)CC1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20100056508A1,Nc1cc(CCN(CCN(C(=O)CCN(CCc2ccccc2)C(=O)OCc2ccccc2)C2CCCCC2)C(=O)OCc2ccccc2)ccc1OCc1ccccc1.O=CO>>O=CNc1cc(CCN(CCN(C(=O)CCN(CCc2ccccc2)C(=O)OCc2ccccc2)C2CCCCC2)C(=O)OCc2ccccc2)ccc1OCc1ccccc1,,C1CCOC1,CCOC(C)=O,CC(=O)OC(C)=O,,val
US20100291003A1,COC(=O)c1ccc(C=C(C(=O)NC2CC2)c2ccc(C)cc2)cc1>>Cc1ccc(C(=Cc2ccc(C(=O)O)cc2)C(=O)NC2CC2)cc1,,CO,O,[Na+].[OH-],,val
US20140094459A1,CCc1cc2c(Cl)ncnc2n1C[C@@H]1CCCN1C(=O)OC(C)(C)C.O=C1CCC(=O)N1I>>Cc1c(I)c2c(Cl)ncnc2n1C[C@@H]1CCCN1C(=O)OC(C)(C)C,,CN(C)C=O,,,,val
US20050054712A1,Cc1cc(C2(c3cc(C)c(O[Si](C)(C)C(C)(C)C)c(C)c3)C(=O)Nc3ccccc32)cc(C)c1O[Si](C)(C)C(C)(C)C.O=S(=O)(Cl)c1ccccc1>>Cc1cc(C2(c3cc(C)c(O)c(C)c3)C(=O)N(S(=O)(=O)c3ccccc3)c3ccccc32)cc(C)c1O,,CCCCCC,CCOC(C)=O,C1CCOC1,[H-].[Na+],val
US04439433,CC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCCBr)c3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)[C@H]2SC1.CCNCC>>CC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCCBr)c3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)[C@H]2SC1.CCNCC,,CCOC(C)=O,,,,val
US20160046608A1,CC(C)(C)OC(=O)N1CCC(C#N)(c2cc(Nc3cc(C(F)(F)F)ccn3)nc(Cl)n2)CC1.FC1(F)CCNC1>>CC(C)(C)OC(=O)N1CCC(C#N)(c2cc(Nc3cc(C(F)(F)F)ccn3)nc(N3CCC(F)(F)C3)n2)CC1,,C1COCCO1,,CCN(C(C)C)C(C)C,Cl,val
US20060035956A1,CCOC(=O)Cn1ccc2ccc(N)cc21.CS(=O)(=O)OCCCC#Cc1ccc(OC(F)(F)F)cc1>>CCOC(=O)Cn1ccc2ccc(NCCCC#Cc3ccc(OC(F)(F)F)cc3)cc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020052512A1,COC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1ccc(C(=O)NCc2cccc3c2cnn3C2CCCCO2)cc1Cl>>O=C(NCc1cccc2c1cnn2C1CCCCO1)c1ccc(C(=O)N[C@@H](CNC(=O)c2cccs2)C(=O)O)c(Cl)c1,,CO,,[Na+].[OH-],,val
US20050020623A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@H](Oc2cccc3c(Cl)nccc23)CC1.N>>Cl.Nc1nccc2c(O[C@@H]3CC[C@H](N)CC3)cccc12,,C1COCCO1,,,,val
US20090153041A1,O=C(Nc1ccccc1O)c1ccc(Br)cc1>>Brc1ccc(-c2nc3ccccc3o2)cc1,,O,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US20010025049A1,CC(C)(C)[Si](C)(C)Oc1ccc(Br)c2ccc(C(F)(F)F)nc12>>Oc1ccc(Br)c2ccc(C(F)(F)F)nc12,,CO,,Cl,O,val
US20050119325A1,COC(=O)CS.O=Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-]>>COC(=O)c1cc2c([N+](=O)[O-])cccc2s1,,CS(C)=O,,CCN(CC)CC,,val
US20160194302A1,CN(C)C1CCN(C(=O)CCc2nccn2CCN)CC1.Cl>>CN(C)C1CCN(C(=O)CCc2nccn2CCN)CC1.Cl,,CCOCC,,,,val
US04038396,Cc1ccc([N+](=O)[O-])c(N)n1.O=N[O-]>>Cc1ccc([N+](=O)[O-])c(=O)[nH]1,,O,,O=S(=O)(O)O,,val
US20090233907A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@H](N)CC1.O=C(O)c1cccnc1NC1CCSCC1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](NC(=O)c2cccnc2NC2CCSCC2)CC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130137708A1,C=CC(=O)Cl.CC(C)n1nc(-c2cccc(N)c2)c2c(N)ncnc21>>C=CC(=O)Nc1cccc(-c2nn(C(C)C)c3ncnc(N)c23)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20090105211A1,Cc1cc(F)ccc1[N+](=O)[O-].c1cn[nH]c1>>Cc1cc(-n2cccn2)ccc1[N+](=O)[O-],,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20140154179A1,CCOC(=O)c1cc[nH]n1.CS(=O)(=O)OC1CCOCC1>>O=C(O)c1ccn(C2CCOCC2)n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050143443A1,CCOC(=O)C(=O)CC(=O)CCCC(C)C.NN>>CCOC(=O)c1cc(CCCC(C)C)[nH]n1,,CCO,,O,,val
US20050113379A1,CB(O)O.CNc1cnc(Br)c(-c2ccc(OC(F)(F)F)cc2OC)n1>>CNc1cnc(C)c(-c2ccc(OC(F)(F)F)cc2OC)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20150266867A1,CC(C)(C)OC(=O)NCc1ncnn1C[C@H]1NC(=O)[C@H]1N.CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)O)cs1>>CC(C)(C)OC(=O)NCc1ncnn1C[C@H]1NC(=O)[C@H]1NC(=O)/C(=N\OC(C)(C)C(=O)OC(C)(C)C)c1csc(NC(=O)OC(C)(C)C)n1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100113462A1,CCOC(=O)C1(N)Cc2ccc(OC)cc2C1.Cc1cccc(C(=O)O)c1OC(C)C>>CCOC(=O)C1(NC(=O)c2cccc(C)c2OC(C)C)Cc2ccc(OC)cc2C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100331295A1,COC(=O)c1cc(-c2ccc(-c3cccc(S(C)(=O)=O)c3)s2)n(-c2ccccc2Cl)n1>>CS(=O)(=O)c1cccc(-c2ccc(-c3cc(C(=O)O)nn3-c3ccccc3Cl)s2)c1,,CO,,[Na+].[OH-],,val
US20150376172A1,CCOC(=O)C1=NOC(C)(C(F)(F)F)C1>>CC1(C(F)(F)F)CC(CO)=NO1,,CCO,,[BH4-].[Na+],,val
US20040209921A1,CC(NCCCCN1C(=O)c2ccccc2C1=O)c1ccccn1.CC(OS(C)(=O)=O)c1ccccn1>>CC(c1ccccn1)N(CCCCN1C(=O)c2ccccc2C1=O)C(C)c1ccccn1,CN(C)c1ccncc1,CC#N,,CCN(C(C)C)C(C)C,,val
US04022607,CSc1nc(-c2ccccc2)c(C)s1.O=C(OO)c1cccc(Cl)c1>>Cc1sc(S(C)=O)nc1-c1ccccc1,,ClCCl,,,,val
US20090105214A1,CCn1ccc(NC(=O)c2cc(O)cc(O[C@@H](C)COC)c2)n1.CN(CCO[Si](C)(C)C(C)(C)C)C(=O)c1ccc(F)c(F)c1F>>CCn1ccc(NC(=O)c2cc(Oc3ccc4c(c3F)OCCN(C)C4=O)cc(O[C@@H](C)COC)c2)n1,,CC(=O)N(C)C,,O,O=C([O-])[O-].[K+].[K+],val
US20080255092A1,CC(C)C[Mg]Cl.CON(C)C(=O)c1ccc(O)nc1>>CC(C)CC(=O)c1ccc(O)nc1,,C1CCOC1,,,,val
US20120258982A1,COC(=O)c1ccc(/C=C/C(=O)c2ccc(Cl)cc2Nc2ccccc2)cc1>>COC(=O)c1ccc(CCC(=O)c2ccc(Cl)cc2Nc2ccccc2)cc1,,CCOC(C)=O,,,,val
US20160214958A1,Brc1cc(Br)c2ccccc2n1.CC(C)(C)OC(=O)N1CCCC[C@@H]1C=O>>CC(C)(C)OC(=O)N1CCCC[C@@H]1[C@@H](O)c1cc(Br)nc2ccccc12,,C1CCOC1,C1CCOC1,[Cl-].[NH4+],,val
US20040077667A1,C1=C(c2ccccc2)CCNC1.NC(=O)c1ccccc1NC(=O)CCCBr>>NC(=O)c1ccccc1NC(=O)CCCN1CC=C(c2ccccc2)CC1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20140038999A1,CC(C)(C)OC(=O)Nc1nccc(-c2ccc(Cl)cc2F)c1C=O.CN>>C[n+]1cc2c(NC(=O)OC(C)(C)C)nccc2c2ccc(Cl)cc21.[F-],,CCO,,,,val
US05091432,CCOC(=O)CCn1cnc2c1N=CNC2N.O=N[O-]>>CCOC(=O)CCn1cnc2c(=O)[nH]cnc21,,O,,CC(=O)O,,val
US20110224257A1,C=CCBr.O=C(Cn1nc(C(F)F)cc1C(F)F)N1CCC(c2nc(C3=NOC(c4ccccc4O)C3)cs2)CC1>>C=CCOc1ccccc1C1CC(c2csc(C3CCN(C(=O)Cn4nc(C(F)F)cc4C(F)F)CC3)n2)=NO1,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090298883A1,N#CCBr.O=C(NCC1CCNCC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>N#CCN1CCC(CNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20070112068A1,FC(F)=C(F)CCBr.N#CC(C#N)CC(F)(F)C(F)(F)C(F)(F)C(F)F>>N#CC(C#N)(CCC(F)=C(F)F)CC(F)(F)C(F)(F)C(F)(F)C(F)F,,COCCOC,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060052374A1,C1CCOC1.C1CCOC1.CO>>OCc1cccc2c1OCC2,,C1CCOC1,,B,,val
US20160272617A1,Cc1cc(C(=O)NC(C)C)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)O)cc1.Cn1c(=O)[nH]c2cc(N)ccc21>>Cc1cc(C(=O)NC(C)C)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3c(c2)[nH]c(=O)n3C)cc1,,CCOC(C)=O,CS(C)=O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20060128924A1,CNS(=O)(=O)c1ccc(C)cc1.O=C(Cl)Oc1ccccc1>>Cc1ccc(S(N)(=O)=O)c(C(=O)Oc2ccccc2)c1,,Clc1ccccc1Cl,,,,val
US20020094983A1,CC(C)(O)c1cc(Br)ccc1N.COC(O)C(F)(F)F>>CC1(C)OC(C(F)(F)F)Nc2ccc(Br)cc21,,Cc1ccccc1,,O=S(=O)([O-])[O-].[Mg+2],,val
US04588819,O=C1N[C@H](CO)C[C@H]1C1CCCCC1>>OC[C@@H]1C[C@@H](C2CCCCC2)CN1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030027743A1,CC(=C=O)[C@H](NOCc1ccccc1)C(=O)O.CCCCNC(=O)C1Nc2ccccc2C1(C)C>>CCCCNC(=O)C1N(C(=O)[C@H](CC)NC(=O)OCc2ccccc2)c2ccccc2C1(C)C,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,O=C1OCCN1P(=O)(Cl)N1CCOC1=O,val
US20140256729A1,COC1(OC)CCC(C(N)=O)CC1>>NC(=O)C1CCC(=O)CC1,,CC(C)=O,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20160264598A1,COc1c(CC(NC(C)=O)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)O.O=C1OC(Br)c2ccccc21>>COc1c(CC(NC(C)=O)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)OC1OC(=O)c2ccccc21,,CCOC(C)=O,CN(C)C=O,[I-].[K+],O=C([O-])O.[Na+],val
US20160207922A1,CC(C)(C)OC(=O)N1CCC2(CC1)CC(=O)N(c1ccc(N)c(F)c1)C2.CCOC(OCC)OCC.[N-]=[N+]=[N-]>>CC(C)(C)OC(=O)N1CCC2(CC1)CC(=O)N(c1ccc(-n3cnnn3)c(F)c1)C2,,CC(=O)O,,O,,val
US20050014727A1,COc1ccc(C(O)c2ccc(OC)c([N+](=O)[O-])c2)cc1OC>>COc1ccc(C(=O)c2ccc(OC)c([N+](=O)[O-])c2)cc1OC,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20050130983A1,COC(=O)c1cc(S(=O)(=O)Cl)ccc1O.OCCN1CCNCC1>>COC(=O)c1cc(S(=O)(=O)N2CCN(CCO)CC2)ccc1O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05043327,COc1ccc(CC#N)cc1.O=[N+]([O-])c1ccccc1CO>>COc1ccc(C(C#N)=C2C=CC(=NO)C(CO)=C2)cc1,,c1ccncc1,,Cl,[K+].[OH-],val
US20060199804A1,Brc1cn[nH]c1.Clc1nccc(N2CCOCC2)n1>>Brc1cnn(-c2nccc(N3CCOCC3)n2)c1,,CN(C)C=O,,O,[H-].[Na+],val
US05990144,Nc1c(OCCN(Cc2ccccc2)C(=O)C(F)(F)F)cccc1[N+](=O)[O-].O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1c(OCCN(Cc2ccccc2)C(=O)C(F)(F)F)cccc1[N+](=O)[O-])C(F)(F)F,,CCOCC,ClCCl,,,val
US20040157885A1,CCOC(=O)c1cc([C@H]2CCCN(C(=O)c3sc(-c4ccc(C(F)(F)F)cc4)nc3C)C2)ccc1C>>Cc1ccc([C@H]2CCCN(C(=O)c3sc(-c4ccc(C(F)(F)F)cc4)nc3C)C2)cc1C(=O)O,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US20080004309A1,CCOC(=O)CNCc1ccc(OC)cc1OC.CCOC(=O)c1sc(Oc2ccccc2)nc1CBr>>CCOC(=O)CN(Cc1ccc(OC)cc1OC)Cc1nc(Oc2ccccc2)sc1C(=O)OCC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110288069A1,O=C1CC2CN(Cc3ccccc3)CCN2c2ccccc2N1>>c1ccc(CN2CCN3c4ccccc4NCCC3C2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04734418,CCn1ccc2c(c1=O)CN=C(N1CCN(Cc3ccccc3)CC1)N2>>CCn1ccc2c(c1=O)CN=C(N1CCNCC1)N2,[Pd],CCO,,[H][H],,val
US20110053897A1,C=CS(C)(=O)=O.CC(C)(C)Nc1nc(Cl)cc2cc[nH]c(=O)c12>>CC(C)(C)Nc1nc(Cl)cc2ccn(CCS(C)(=O)=O)c(=O)c12,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150224104A1,COC(=O)CCC(C(N)=O)N1Cc2c(O)cccc2C1=O.OCc1ccc(OCCN2CCOCC2)cc1>>COC(=O)CCC(C(N)=O)N1Cc2c(OCc3ccc(OCCN4CCOCC4)cc3)cccc2C1=O,,C1CCOC1,ClCCl,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US03941821,CCNCC.O=C(O)C(Cl)c1ccc(-c2ccccc2Cl)cc1>>CC[NH2+]CC.O=C([O-])C(Cl)c1ccc(-c2ccccc2Cl)cc1,,CCCCCC,,,,val
US20040102437A1,NCC1CCCCC1.O=C1CCC(Nc2ccc3[nH]ncc3c2)CC1>>c1cc2[nH]ncc2cc1NC1CCC(NCC2CCCCC2)CC1,,CO,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130072467A1,O=C1N=C(NCc2ccon2)CS1.O=CC1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1>>O=C1N=C(NCc2ccon2)/C(=C/C2CCN(Cc3ccc(C(F)(F)F)cc3C(F)(F)F)CC2)S1,,CC(C)O,,C1CC[NH2+]CC1.CC(=O)[O-],,val
US07745641B2,CO.COCOc1c(C(OC)OC)cc(I)c2c1C(O)N(C(C)(C)c1ccccc1)C2=O>>COC1c2c(O)c(C=O)cc(I)c2C(=O)N1C(C)(C)c1ccccc1,,CO,,Cl,,val
US20020115674A1,CC(C)(C)OC(=O)NC1CCNC1.CCn1c(=O)n(OCc2ccccc2)c(=O)c2cc(F)c(Cl)nc21>>CCn1c(=O)n(OCc2ccccc2)c(=O)c2cc(F)c(N3CCC(NC(=O)OC(C)(C)C)C3)nc21,,ClCCl,,CCN(CC)CC,,val
US05262543,CC1(C)CCC(Cc2ccc(Cl)cc2)C1(O)COS(C)(=O)=O.c1nc[nH]n1>>CC1(C)CCC(Cc2ccc(Cl)cc2)C1(O)Cn1cncn1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20140353649A1,COc1ccc(P(=O)(c2ccccc2)c2ccccc2)cc1>>O=P(c1ccccc1)(c1ccccc1)c1ccc(O)cc1,,ClCCl,ClCCl,BrB(Br)Br,,val
US05670505,O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12>>O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNC[C@H]1Cc1c[nH]c2ccccc12,,CCO,,O=C[O-].[NH4+],,val
US20100273850A1,COC(=O)Cc1ccc(-n2ccc3cc(C(=O)NCCc4ccc(Cl)cc4Cl)ccc32)c(C#N)c1>>N#Cc1cc(CC(=O)O)ccc1-n1ccc2cc(C(=O)NCCc3ccc(Cl)cc3Cl)ccc21,O,CO,ClCCl,[Na+].[OH-],,val
US20100273764A1,COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(C(OS(C)(=O)=O)c4ccc(S(=O)(=O)N(C)C)cc4)cnc3Nc3ccc(OC)nc3)n2)cc1.N>>COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(C(N)c4ccc(S(=O)(=O)N(C)C)cc4)cnc3Nc3ccc(OC)nc3)n2)cc1,,C1COCCO1,ClCCl,,,val
US20120196864A1,CCN(CC)CCN.COc1cc(C=O)ccc1Oc1ccc(C#N)c(C(F)(F)F)c1.O=C1NC(=S)CS1>>CCN(CC)CCNC1=NC(=O)S/C1=C\c1ccc(Oc2ccc(C#N)c(C(F)(F)F)c2)c(OC)c1,,CCO,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20060167264A1,C#CCN.O=S(=O)(Cl)c1cnccc1C(F)(F)F>>C#CCNS(=O)(=O)c1cnccc1C(F)(F)F,,C1COCCO1,Cl,,,val
US04749812,CC(C)c1ccc(N)cc1Cl.O=C(OC(=O)C1CC1)C1CC1>>CC(C)c1ccc(NC(=O)C2CC2)cc1Cl,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06703082B1,O=C(OCc1ccccc1)C1CCc2cc(OCc3ccccc3)ccc2C1>>O=C(O)C1CCc2cc(OCc3ccccc3)ccc2C1,,CCO,O,[K+].[OH-],,val
US20150148313A1,COB(OC)OC.Cc1cc(Br)cc(C)c1C(F)(F)CO[Si](C)(C)C(C)(C)C>>Cc1cc(B(O)O)cc(C)c1C(F)(F)CO[Si](C)(C)C(C)(C)C,,C1CCOC1,,[Li]CCCC,,val
US20130023568A1,Nc1ccc2[nH]ncc2c1[N+](=O)[O-]>>Nc1ccc2[nH]ncc2c1N,[Pd],,,,,val
US05310895,CC(=O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1Br>>CC(=O)OC[C@@H]1C[C@@H](O)[C@H](n2cnc3c(N)ncnc32)O1,[Pd],CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20100210656A1,CNc1nc(C)nc(NC2CCCC(C(=O)O)C2)n1.N#Cc1ccc(CN)c(C(F)(F)F)c1>>CNc1nc(C)nc(N[C@@H]2CCC[C@H](C(=O)NCc3ccc(C#N)cc3C(F)(F)F)C2)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20080167303A1,CC(C)(C)OC(=O)N1CCN(CCN2c3ccccc3N(c3ccc(F)c(F)c3)S2(=O)=O)CC1>>O=S1(=O)N(CCN2CCNCC2)c2ccccc2N1c1ccc(F)c(F)c1,,C1COCCO1,ClCCl,Cl,,val
US05707987,CC(C)(C)OC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]1C=O.COCOCc1ccc(Br)cc1>>COCOCc1ccc(C(O)[C@@H]2C[C@@H](O[Si](C)(C)C(C)(C)C)CN2C(=O)OC(C)(C)C)cc1,,C1CCOC1,O,CCOC(C)=O,[Cl-].[NH4+],val
US20100022598A1,CCC(C)(C)Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(C)n1.CON(C)C(=O)c1ccc(-c2ccc(F)cn2)cc1>>CCC(C)(C)Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(CC(=O)c2ccc(-c3ccc(F)cn3)cc2)n1,,C1CCOC1,,[Li]CCCC,,val
US06159979,COc1ccc(NC(=O)c2cccc3c(Br)cccc23)cc1N1CCN(C)CC1.OB(O)c1ccncc1>>COc1ccc(NC(=O)c2cccc3c(-c4ccncc4)cccc23)cc1N1CCN(C)CC1,,COCCOC,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20080042129A1,O=C1CCC(=O)N1Br.c1csc(-c2ccsc2-c2ccsc2-c2cccs2)c1>>Brc1ccsc1-c1sccc1-c1sccc1-c1cccs1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20040198751A1,CC1(C)OB(c2ccc(N)cc2)OC1(C)C.Cn1nc(Cl)c2cnc(NCCO)nc21>>Cn1nc(-c2ccc(N)cc2)c2cnc(NCCO)nc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20160115128A1,CCOC(=O)CC(c1ccnc(OCC2CCNCC2)c1)C1CC1.Cc1cccc(N(CC(C)(C)C)C(=O)c2c(F)cc(Cl)cc2F)n1>>CCOC(=O)CC(c1ccnc(OCC2CCN(c3cc(Cl)cc(F)c3C(=O)N(CC(C)(C)C)c3cccc(C)n3)CC2)c1)C1CC1,,CCOC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040092546A1,NN.O=C(c1cc[nH]c1)c1ccc(Cl)nc1Cl>>Clc1ccc2c(-c3cc[nH]c3)n[nH]c2n1,,CCO,,O,,val
US06228859B1,COc1ccc(CO)cc1O.ClCc1ccccc1>>COc1ccc(CO)cc1OCc1ccccc1,,CCCO,,CC(C)(C)[O-].[K+],,val
US05721347,Cn1cccc1CC#N.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>Cn1c(CC#N)ccc1C(=O)c1ccc([N+](=O)[O-])cc1,,ClCCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US04748240,NCCCCN1CCN(c2cncc(Cl)n2)CC1.O=C1OC(=O)C2CCC1O2>>O=C1C2CCC(O2)C(=O)N1CCCCN1CCN(c2cncc(Cl)n2)CC1,,ClCCl,,,,val
US20030055071A1,C=CS(=O)(=O)NCCNC(=O)OC(C)(C)C.Cl>>C=CS(=O)(=O)NCC[NH3+].[Cl-],,CCOC(C)=O,,,,val
US04025636,CC(C#N)c1ccc(O)c(N)c1.O=C(Cl)c1ccc(Cl)cc1>>CC(C#N)c1ccc(O)c(NC(=O)c2ccc(Cl)cc2)c1,,c1ccncc1,,,,val
US20090054407A1,COc1cc(-c2cc3cc(C=O)ccc3n2C(=O)OC(C)(C)C)c2c(c1OS(C)(=O)=O)CNC2=O.NC1CC1>>COc1cc(-c2cc3cc(CNC4CC4)ccc3n2C(=O)OC(C)(C)C)c2c(c1OS(C)(=O)=O)CNC2=O,,CC#N,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20080255149A1,CN(C)c1ccc(N=C=O)cc1.NCc1ccc2c(c1)CN(C(=O)[C@H](N)Cc1ccc(Cl)cc1Cl)C2>>CN(C)c1ccc(NC(=O)NCc2ccc3c(c2)CN(C(=O)[C@H](N)Cc2ccc(Cl)cc2Cl)C3)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20130261103A1,C=O.Cc1c(-c2cc(Nc3cc4n(n3)CCN(C)C4)c(=O)[nH]n2)cccc1N1Cc2cc(C(C)(C)C)sc2C1=O>>Cc1c(-c2cc(Nc3cc4n(n3)CCN(C)C4)c(=O)n(CO)n2)cccc1N1Cc2cc(C(C)(C)C)sc2C1=O,,CO,,,,val
US20040157886A1,Nc1ccc(NC(=O)C(=O)N2CCC(Cc3ccc(F)cc3)CC2)cc1.O=Cc1ccccc1>>O=C(Nc1ccc(NCc2ccccc2)cc1)C(=O)N1CCC(Cc2ccc(F)cc2)CC1,,CCOCC,,,,val
US20050020645A1,CCOC(=O)C(=O)Cl.Nc1ccc(Cl)cn1>>COC(=O)C(=O)Nc1ccc(Cl)cn1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20090270467A1,C#CCN(CC#C)S(=O)(=O)c1ccc(C)cc1.O=C(O)Cc1cccs1>>Cc1ccc(S(=O)(=O)N2Cc3cscc3C2)cc1,,c1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US05080708,COC(=O)c1c(C)noc1C(=O)NC(C)(C)C.N>>Cc1noc(C(=O)NC(C)(C)C)c1C(N)=O,,O,,,,val
US20090253705A1,O=C(OCc1ccccc1)C1CCc2ccnn21>>O=C(O)C1CCc2ccnn21,[Pd],CCO,,[H][H],,val
US20150045351A1,CC(=O)N1CC2CN(C(=O)OC(C)(C)C)CCc3cccc1c32.Cl>>CC(=O)N1CC2CNCCc3cccc1c32.Cl,,CCO,,CCOC(C)=O,,val
US20090088428A1,CCOC(=O)C(Cc1c(Cl)cc(OCc2ccccc2)cc1Cl)(CC(OC)OC)C(=O)OCC>>CCOC(=O)C(CC=O)(Cc1c(Cl)cc(OCc2ccccc2)cc1Cl)C(=O)OCC,,CC(C)=O,,O=CO,,val
US20080194696A1,CO.CSC1(S(=O)(=O)c2ccccc2)C[C@@H]2C[C@]2(c2ccc(Cl)c(Cl)c2)C1>>O=C1C[C@@H]2C[C@]2(c2ccc(Cl)c(Cl)c2)C1,,CCCCCC,CCOC(C)=O,Cl,,val
US05965730,COc1ccc(C[C@@H](COC(=O)c2ccnc(Br)c2)NC(=O)c2ccnc(Br)c2)cc1OC>>COc1ccc(C[C@@H](CO)NC(=O)c2ccnc(Br)c2)cc1OC,,CO,,[Li+].[OH-],,val
US05556864,C(C=Cc1ccccc1OCc1ccccc1)=Cc1ccccc1>>Oc1ccccc1CCCCc1ccccc1,[Pd],CCO,,[H][H],,val
US20110212967A1,CC(=O)Cl.C[C@H](NC(=O)OC(C)(C)C)/C(N)=N/O>>CC(=O)O/N=C(\N)[C@H](C)NC(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20060281914A1,CC[Si](Cl)(CC)CC.C[Si](C)(C)OCC(=O)O[Si](C)(C)C>>CC[Si](CC)(CC)OC(=CO[Si](C)(C)C)O[Si](C)(C)C,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20040009995A1,CCOC(=O)c1cc(S(=O)(=O)c2cc(OC(C)(C)C)cc(-c3ccccc3)c2)c(SC)s1>>CCOC(=O)c1cc(S(=O)(=O)c2cc(O)cc(-c3ccccc3)c2)c(SC)s1,,ClCCl,O=C(O)C(F)(F)F,,,val
US06001867,COC(=O)COc1ccc(-c2c(Br)ccc3sc4ccccc4c23)cc1>>O=C(O)COc1ccc(-c2c(Br)ccc3sc4ccccc4c23)cc1,,C1CCOC1,CO,[K+].[OH-],,val
US20110144105A1,CCSc1cnc2c(c1)CCN2[Si](C)(C)C(C)(C)C>>CCSc1cnc2c(ccn2[Si](C)(C)C(C)(C)C)c1,,ClCCl,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20050070584A1,COC(=O)c1ccc(OCCCO/N=C/c2ccc(-c3ccccc3)cc2)cc1NC(=O)c1ccc(OC(F)(F)F)cc1>>O=C(Nc1cc(OCCCO/N=C/c2ccc(-c3ccccc3)cc2)ccc1C(=O)O)c1ccc(OC(F)(F)F)cc1,,C1CCOC1,,CO,[Li+].[OH-],val
US04552765,CC(=O)Cl.O=C(CCNC(=O)OCc1ccccc1)NCCS>>CC(=O)SCCNC(=O)CCNC(=O)OCc1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20120077799A1,Nc1ncccc1Br.OB(O)c1ccc(OC(F)(F)F)cc1>>Nc1ncccc1-c1ccc(OC(F)(F)F)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100292208A1,CCn1c(CO)cc2cc(Oc3nc4ccccc4s3)ccc21>>CCn1c(C=O)cc2cc(Oc3nc4ccccc4s3)ccc21,O=[Mn]=O,ClC(Cl)Cl,,,,val
US20160007603A1,CCOC(=O)c1cc(OCC(F)F)nn1-c1ncccc1Cl>>O=C(O)c1cc(OCC(F)F)nn1-c1ncccc1Cl,,CCO,,Cl,[Na+].[OH-],val
US20120225857A1,CC(Oc1ccc(Br)cc1)C1CC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(Oc1ccc(B2OC(C)(C)C(C)(C)O2)cc1)C1CC1,,CN(C)C=O,,CC(=O)[O-].[K+],,val
US03984467,CCCCC(=N)N.O=C=Nc1ccc([N+](=O)[O-])cc1>>CCCCC(=N)NC(=O)Nc1ccc([N+](=O)[O-])cc1,,CC(C)=O,,Cl,[Na],val
US06362177B1,CSc1ccc(CN2CCC(CNC(=O)CNC(=O)OCC3c4ccccc4-c4ccccc43)CC2)cc1>>CSc1ccc(CN2CCC(CNC(=O)CN)CC2)cc1,,CN(C)C=O,,C1CCNCC1,,val
US20100029678A1,O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.O=C(O[C@@H]1CO[C@@H]2[C@H](O)CO[C@H]12)N1CCC(O[N+](=O)[O-])CC1>>O=C(Oc1ccc([N+](=O)[O-])cc1)O[C@@H]1CO[C@@H]2[C@H](OC(=O)N3CCC(O[N+](=O)[O-])CC3)CO[C@H]12,,C1CCOC1,,CCN(CC)CC,,val
US06432993B1,CN(C(=O)OC(C)(C)C)c1cc(Oc2ccc(NC(=O)OC(C)(C)C)cc2)ccc1N.O=C(O)COc1ccc(CC2SC(=O)NC2=O)cc1>>CN(C(=O)OC(C)(C)C)c1cc(Oc2ccc(N)cc2)ccc1NC(=O)COc1ccc(CC2SC(=O)NC2=O)cc1,,C1CCOC1,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20130005741A1,CCOC(=O)CC1CCCNC1.COc1nc(Cl)cc(NCCc2ccc(OC(F)(F)F)cc2)n1>>CCOC(=O)CC1CCCN(c2cc(NCCc3ccc(OC(F)(F)F)cc3)nc(OC)n2)C1,,CN1CCCC1=O,O,O=C([O-])[O-].[K+].[K+],,val
US06303612B1,COc1ccc(Sc2ccccc2CC#N)cc1.O.[OH-]>>COc1ccc(Sc2ccccc2CC(=O)O)cc1,,CCO,,Cl,,val
US20090239876A1,COC(=O)CC(=O)NCc1ccc(Br)cc1.COC(OC)N(C)C>>COC(=O)C(=CN(C)C)C(=O)NCc1ccc(Br)cc1,,C1CCOC1,,,,val
US20080085869A1,CCCCCCCCCCCCCCCCCC(=O)CC(=O)OC>>CCCCCCCCCCCCCCCCCC(O)CCO,,C1CCOC1,,[BH4-].[Li+],,val
US04567276,CC1OC1Oc1ccc(-c2nccn2C)cc1.COc1ccc(CCN)cc1OC>>COc1ccc(CCNCC(O)COc2ccc(-c3nccn3C)cc2)cc1OC,,CC(C)O,,,,val
US20160009683A1,CC(=O)OCCc1cccc(I)c1.CCOC(=O)C(F)(F)Br>>CCOC(=O)C(F)(F)c1cccc(CCOC(C)=O)c1,[Cu],CS(C)=O,,[Cl-].[NH4+],,val
US04537899,CSc1n[nH]c(N)n1.O=C(Cl)c1ccc(Cl)cc1>>CSc1nc(N)n(C(=O)c2ccc(Cl)cc2)n1,,C1COCCO1,,O,c1ccncc1,val
US20080069968A1,CCCCCOc1ccc(OC(=O)/C=C/c2ccc(O)cc2)cc1.OCCCCCCCl>>CCCCCOc1ccc(OC(=O)/C=C/c2ccc(OCCCCCCCl)cc2)cc1,,C1CCOC1,Cc1ccccc1,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040029874A1,CC(C)=O.O=C(Nc1ccc(F)cn1)c1cc(Cl)ccc1NCC1CCNCC1>>CC(C)N1CCC(CNc2ccc(Cl)cc2C(=O)Nc2ccc(F)cn2)CC1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20080033177A1,COc1ccc2c(c1)CCN(CN1CCc3cc(OC)ccc3C1)C2.Cl>>COc1ccc2c(c1)CCNC2.Cl,,CC(C)O,,,,val
US20140275028A1,O=[N+]([O-])c1cc(OCc2ccc3ccccc3n2)ccc1NCc1ccc(C(F)(F)F)cc1>>Nc1cc(OCc2ccc3ccccc3n2)ccc1NCc1ccc(C(F)(F)F)cc1,[Pt],C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20110059951A1,CC(C)(C)OC(=O)N1CCN(CC=CC#N)C(CO[Si](C)(C)C(C)(C)C)C1.C[Si](C)(C)CCOCn1ccc2c(-c3cn[nH]c3)ncnc21>>CC(C)(C)OC(=O)N1CCN(CC(CC#N)n2cc(-c3ncnc4c3ccn4COCC[Si](C)(C)C)cn2)C(CO[Si](C)(C)C(C)(C)C)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100216814A1,CC1(c2ccncc2)CO1.CN1CCc2[nH]c3cc(Cl)ccc3c2C1>>CN1CCc2c(c3ccc(Cl)cc3n2CC(C)(O)c2ccncc2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20060217387A1,Nc1ccncc1.O=S(=O)(Cl)c1ccc(Br)s1>>O=S(=O)(Nc1ccncc1)c1ccc(Br)s1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20130344030A1,CC(C)[C@H](OC(=O)C1(/C=C/c2ccc3ccc([C@@H](C)NC(=O)OC(C)(C)C)nc3c2)CCCCO1)C(=O)N[C@@H](C)C(=O)N1CCC[C@@H](C(=O)OCC(Cl)(Cl)Cl)N1>>CC(C)[C@H](OC(=O)C1(/C=C/c2ccc3ccc([C@@H](C)NC(=O)OC(C)(C)C)nc3c2)CCCCO1)C(=O)N[C@@H](C)C(=O)N1CCC[C@@H](C(=O)O)N1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20100331312A1,CC1CCCN1.CS(=O)(=O)OCCc1ccc(Br)cc1>>CC1CCCN1CCc1ccc(Br)cc1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20110288097A1,CC1(C)CCN(S(C)(=O)=O)CC1NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(C3CC3)nc12>>CC1(C)CCN(S(C)(=O)=O)CC1NC(=O)c1c[nH]c2ncc(C3CC3)nc12,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US20120142707A1,C=C(C)[C@@H]1CC[C@]2(COC(=O)c3ccccc3)CC[C@]3(C)C(CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(COC(=O)c3ccccc3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20050245530A1,O=C(CC(=O)Nc1ccc(Oc2cc(Nc3ccc(OCc4ccccc4)cc3)ncn2)c(F)c1)Nc1ccc(F)cc1>>Nc1cc(Oc2ccc(NC(=O)c3ccnc(Nc4ccc(F)cc4)c3)cc2F)ccn1,,ClCCCl,,CCOC(C)=O,O=C([O-])O.[Na+],val
US08476287B2,CC(C)(CO)CO.OB(O)c1ccc(O)cc1>>CC1(C)COB(c2ccc(O)cc2)OC1,,Cc1ccccc1,,,,val
US20130172317A1,CCOC(=O)C(CBr)=NOC.CCSc1nc(=O)[nH]c(=O)n1Cc1ccc(Cl)cc1>>CCOC(=O)C(Cn1c(=O)nc(SCC)n(Cc2ccc(Cl)cc2)c1=O)=NOC,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05681543,COC(=O)C(F)(F)F.N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O>>O=C(O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(F)(F)F,,CO,,CCN(CC)CC,O,val
US03970454,CCCc1cc(N=Nc2ccccc2)c2c(c1O)[N+](C)(C)CCC2.[Br-]>>CCCc1cc(N)c2c(c1O)[N+](C)(C)CCC2.[Br-],[Pd],CO,,O,[H][H],val
US07390830B1,CCOC(=O)C1CCCN(Cc2ccc(Cl)cc2)C1>>O=C(O)C1CCCN(Cc2ccc(Cl)cc2)C1,,C1CCOC1,,O,[Li+].[OH-],val
US20080032972A1,CI.Clc1ccc(Cl)c(CN2CCNc3ncc(I)cc32)c1>>CN1CCN(Cc2cc(Cl)ccc2Cl)c2cc(I)cnc21,,CN(C)C=O,,[H-].[Na+],,val
US04083990,BrCCCCBr.CCOC(=O)C(C)OCCCCI>>CCOC(=O)C(C)OCCCCBr,,C1CCOC1,,[H-].[Na+],,val
US04057556,CO.O=c1ccccc(Br)c1O>>COc1ccccc(=O)c1O,,CO,,[Na],C[O-].[Na+],val
US20090281140A1,COc1ccc2c(Cl)cc[n+]([O-])c2c1C.OCc1ccccc1>>COc1ccc2c(OCc3ccccc3)cc[n+]([O-])c2c1C,,CN(C)C=O,,O,[H-].[Na+],val
US20140113884A1,CC(C)NCCCCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.CCCCCCC(=O)O>>CCCCCCC(=O)N(CCCCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)C(C)C,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CCN=C=NCCCN(C)C,val
US20140329799A1,CC(C)(C)c1ccc2sc(S)nc2c1>>CC(C)(C)c1ccc2scnc2c1,[Fe],CC(=O)O,,,,val
US20090181963A1,CCn1nnc2c(N3CCOC[C@@H]3C)nc(-c3ccc(N)cc3)nc21.O=C=Nc1cccs1>>CCn1nnc2c(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4cccs4)cc3)nc21,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20080027049A1,O=[N+]([O-])c1cccc2c3c(oc12)CCC3>>Nc1ccc2oc3c(c2c1)CCC3,[Ni],,,CCO,,val
US20070197393A1,BrBr.CSc1cccc2c1C1=NOCC1C2>>CSc1ccc(Br)c2c1C1=NOCC1C2,,O,,O=S(=O)(O)O,,val
US20110268887A1,CCCCCO.Cc1ccccc1C>>CCCCCO.Cc1ccccc1C,,O,,,,val
US20110065681A1,C=Cc1ccc(C(F)(F)F)nc1.CC(C)(C)O.O>>OC[C@H](O)c1ccc(C(F)(F)F)nc1,,CCOC(C)=O,,O=S([O-])[O-].[Na+].[Na+],,val
US20120258946A1,COCCO.O=[N+]([O-])c1ccc(F)c(F)c1>>COCCOc1ccc([N+](=O)[O-])cc1F,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US05262426,Nc1cccnc1N.O=C(O)c1cccnc1>>c1cncc(-c2nc3ncccc3[nH]2)c1,,O,,[NH4+].[OH-],,val
US20160221953A1,CC(C)CCON=O.O=C1CCc2c(Br)cccc21>>O=C1C(=NO)Cc2c(Br)cccc21,,CCOCC,,Cl,,val
US20080269244A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(N3CCNCC3)nc2C)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(N3CCNCC3)nc2C)cc1,,CO,,Cl,Cl,val
US20060100246A1,COc1ccc(COc2cccc(OCC3CC3)c2-c2cc(C3CCCN(C(=O)OC(C)(C)C)C3)c(C#N)c(/N=C/N)n2)cc1>>COc1ccc(COc2cccc(OCC3CC3)c2-c2cc(C3CCCN(C(=O)OC(C)(C)C)C3)c3c(N)ncnc3n2)cc1,,CO,Cc1ccccc1,O=C(O)C(F)(F)F,,val
US20130252937A1,Cc1cc(S(=O)(=O)CCCO)cc(C)c1[N+](=O)[O-]>>Cc1cc(S(=O)(=O)CCCO)cc(C)c1N,[Pd],CCO,,,,val
US20160102071A1,CC#C[C@@H](CC(=O)OCC)c1ccc(OCc2ccc3scc(-c4cccc(OCCOC)c4C)c3c2)nc1>>CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3scc(-c4cccc(OCCOC)c4C)c3c2)nc1,,CCO,,Cl,[Li+].[OH-],val
US20040058907A1,NCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1.O=C=NCc1ccccc1>>O=C(NCc1ccccc1)NCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1,,ClCCl,,,,val
US20140179715A1,CC(C)(C)OC(=O)N1CCn2c1cc(OCc1ccc(Oc3cc(F)cc(C(F)(F)F)c3)c(C#N)c1)nc2=O>>N#Cc1cc(COc2cc3n(c(=O)n2)CCN3)ccc1Oc1cc(F)cc(C(F)(F)F)c1,,CN(C)C=O,,,,val
US20100152207A1,CI.COc1cc(Cl)c(-c2cnc(C(F)(F)F)cc2C#N)cc1C(=O)Nc1c(C)cccc1C>>COc1cc(Cl)c(-c2cnc(C(F)(F)F)cc2C#N)cc1C(=O)N(C)c1c(C)cccc1C,,CN(C)C=O,,[H-].[Na+],,val
US20080261940A1,CN(C)C=Nc1c(N(C)S(=O)(=O)C(F)(F)F)c(C#N)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl>>CN(c1c(C#N)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N)S(=O)(=O)C(F)(F)F,,CO,,Cl,,val
US20100016309A1,O=C(Cl)CCl.O=C(N1CCc2ccccc2C1)C(F)(F)F>>O=C(CCl)c1ccc2c(c1)CN(C(=O)C(F)(F)F)CC2,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04198419,N#CN1CCC(C#N)(c2ccccc2Sc2ccc(Cl)cc2)CC1>>N#CC1(c2ccccc2Sc2ccc(Cl)cc2)CCNCC1,,ClCCl,O,CC(=O)O,,val
US20150191483A1,CC(=O)OC(C)=O.CCOC(=O)C1(C(N)=O)CCNCC1>>CCOC(=O)C1(C(N)=O)CCN(C(C)=O)CC1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20060293319A1,Clc1ccc([Mg]Br)cc1.O=C1Nc2cc(Cl)ccc2C1=O>>O=C1Nc2cc(Cl)ccc2C1(O)c1ccc(Cl)cc1,,C1CCOC1,,CCOCC,,val
US04608375,N.O=c1[nH]c(=S)c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1>>Nc1nc(=O)n(CCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)c2ccccc12,,CO,ClC(Cl)Cl,,,val
US05763450,O=C(O)c1ccc(I)cc1Cl.O=S(Cl)Cl>>O=C(Cl)c1ccc(I)cc1Cl,,c1ccccc1,,CN(C)C=O,,val
US20120035407A1,C1CCOC1.CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.Cc1ccc2nc(-c3nc(Br)cnc3N)[nH]c2c1>>Cc1ccc2nc(-c3nc(Br)cnc3N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n(C(=O)OC(C)(C)C)c2c1,CN(C)c1ccncc1,C1CCOC1,CC#N,,,val
US20160168131A1,Cc1nc(N)nc(Cl)c1C#N.Cn1cc(-c2c(F)ccc3nc([C@@H]4C[C@H](O)CN4)n(-c4ccccc4)c(=O)c23)cn1>>Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3ccc(F)c(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N,,CCO,,CCN(C(C)C)C(C)C,,val
US20140114068A1,Cc1c(C(=O)NC23C(=O)c4c([N+](=O)[O-])cccc4C2(O)Oc2cc(C(C)C)ccc23)sc2ccccc12>>Cc1c(C(=O)NC23C(=O)c4c(N)cccc4C2(O)Oc2cc(C(C)C)ccc23)sc2ccccc12,[Fe],CCO,,Cl,O,val
US20050203296A1,CC(=O)N1CC(=O)NC(Cc2cccc(Oc3ccccc3)c2)C1=O>>O=C1CNC(=O)C(Cc2cccc(Oc3ccccc3)c2)N1,,CN(C)C=O,O,NN,,val
US20080096905A1,CSc1ccccc1B(O)O.O=c1ccc2c(Cl)nc(NC(CO)CO)nc2n1-c1ccc(C(F)(F)F)cc1>>CSc1ccccc1-c1nc(NC(CO)CO)nc2c1ccc(=O)n2-c1ccc(C(F)(F)F)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](C(O)c3ccc(OC)cc3)CC2)c2ncnn12>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](C(=O)c3ccc(OC)cc3)CC2)c2ncnn12,,CS(C)=O,,CCN(CC)CC,Cl,val
US20030191118A1,COC(=O)[C@H](Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1)NC(=O)c1c(Cl)cccc1Cl>>CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(C[C@H](NC(=O)c2c(Cl)cccc2Cl)C(=O)O)cc1,,C1CCOC1,O,CO,[Li+].[OH-],val
US20150210666A1,CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCOCCCCCCC)[C@@](O)(CCC)C(=O)[O-])C(=O)OC)cc1>>CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCOCCCCCCC)[C@@](O)(CCC)C(=O)O)C(=O)OC)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040138065A1,FC(F)(F)CCBr.N#CC(C#N)Cc1c(F)cc(F)cc1F>>N#CC(C#N)(CCC(F)(F)F)Cc1c(F)cc(F)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US20110166122A1,Fc1ccc(F)c([C@H]2CCCN2)c1.O=[N+]([O-])c1cnc2ccc(Cl)nn12>>O=[N+]([O-])c1cnc2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nn12,,CCOC(C)=O,,CCCCO,,val
US20040077605A1,C1CO1.CCCc1ccco1>>CCCc1ccc(CCO)o1,,C1CCOC1,,[Li]CCCC,,val
US20160184305A1,COc1cc2ccncc2cc1Br.O=C(OO)c1cccc(Cl)c1>>COc1cc2cc[n+]([O-])cc2cc1Br,,ClCCl,,,,val
US08377938B2,NC(=O)c1cc(Cl)ccn1.Nc1ccc(O)cc1F>>Nc1ccc(Oc2ccncc2)cc1F,,CS(C)=O,O,C1CCOC1,CC(C)(C)[O-].[K+],val
US04670447,CN1CCC(c2nn(-c3ccc(F)cc3)c3ccccc23)CC1.N#CBr>>N#CN1CCC(c2nn(-c3ccc(F)cc3)c3ccccc23)CC1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120264735A1,CCOc1cnc(-c2cccc(Cc3nn(-c4cnn(CCOCc5ccccc5)c4)ccc3=O)c2)nc1>>CCOc1cnc(-c2cccc(Cc3nn(-c4cnn(CCO)c4)ccc3=O)c2)nc1,[Pd],CC(C)=O,,O=C[O-].[NH4+],,val
US20090264432A1,Cc1cccc(-c2c(F)cccc2[C@H](OCCN=[N+]=[N-])[C@H]2CN(C(=O)OC(C)(C)C)CCO2)c1>>Cc1cccc(-c2c(F)cccc2[C@H](OCCN)[C@H]2CN(C(=O)OC(C)(C)C)CCO2)c1,[Pd],CCOC(C)=O,,[H][H],,val
US04863952,CCCCCCCO.O=C1CCC(C(=O)O)N1>>CCCCCCCOC(=O)C1CCC(=O)N1,,c1ccccc1,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20140128606A1,C=O.CC(C)(C)OC(=O)N1C[C@H]2CN(c3ccc(-c4ccccc4)nn3)C[C@H]2C1>>CN1C[C@H]2CN(c3ccc(-c4ccccc4)nn3)C[C@H]2C1,,O=CO,,,,val
US20150225394A1,CC(C)(C)[Si](C)(C)OC1CCC(=O)CC1.N#CCC1(N2CCC(N(C(=O)C(F)(F)F)[C@@H]3C[C@H]3c3ccccc3)CC2)CNC1>>CC(C)(C)[Si](C)(C)OC1CCC(N2CC(CC#N)(N3CCC(N(C(=O)C(F)(F)F)[C@@H]4C[C@H]4c4ccccc4)CC3)C2)CC1,,ClCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US04983616,CCOC(C)=O.CN1CCC2(C)c3cc([N+](=O)[O-])ccc3N(C)C12>>CCOC(=O)Nc1ccc2c(c1)C1(C)CCN(C)C1N2C,O=[Pt]=O,,,,,val
US20080091034A1,CN(C)C=O.Clc1ccncc1>>O=Cc1cnccc1Cl,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20070037794A1,COCN(c1cc(Cl)cnc1Br)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1.O=Cc1cc(-n2cccn2)ccc1Cl>>COCN(c1cc(Cl)cnc1C(O)c1cc(-n2cccn2)ccc1Cl)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US04075210,COC(=O)c1cnc(Cl)cc1Cl.Cc1cc(N)[nH]n1>>Cc1cc2[nH]c3cc(Cl)ncc3c(=O)n2n1,,CCCCO,,,,val
US20050143422A1,CCOC(=O)c1oc2cccc(O)c2c1C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)c1oc2cccc(OS(=O)(=O)C(F)(F)F)c2c1C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080292608A1,CC(C)(C)[Si](C)(C)Cl.COC(=O)CCc1cccc(O)c1Br>>COC(=O)CCc1cccc(O[Si](C)(C)C(C)(C)C)c1Br,,ClCCl,,c1c[nH]cn1,,val
US06350735B1,CCN(CC)CC.NCc1nc(NCc2cccc3ccccc23)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1.O=S(=O)(Cl)c1ccccc1>>N.O=S(=O)(NCc1nc(NCc2cccc3ccccc23)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)c1ccccc1,,C1COCCO1,,,,val
US20040214868A1,COC(=O)c1ccc(NC(=O)c2cc(NC(=O)c3ccccc3C)cc(NC(=O)c3ccccc3C)c2)nc1>>Cc1ccccc1C(=O)Nc1cc(NC(=O)c2ccccc2C)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20080161295A1,BrCC[C@H]1CO1.O=S1(=O)NCc2ccccc2N1c1ccccc1F>>O=S1(=O)N(CC[C@H]2CO2)Cc2ccccc2N1c1ccccc1F,,CC(C)=O,CCOCC,O=C([O-])[O-].[K+].[K+],,val
US04533670,O=C(Cn1ccnc1)c1ccc2c(c1)Cc1ccccc1-2.OCCO>>c1ccc2c(c1)Cc1cc(C3(Cn4ccnc4)OCCO3)ccc1-2,,O,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US20110105463A1,CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)NCC(O)c4ccc(Cl)cc4)cc3)c(Cl)cc21>>O=C(NCC(O)c1ccc(Cl)cc1)c1ccc(Oc2cc3c(cc2Cl)C(C(=O)O)CCO3)cc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20110009382A1,COC(=O)c1cccc2[nH]c(CN(C=C=O)OC(C)(C)C)nc12>>CNCc1nc2cccc(C(=O)OC)c2[nH]1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020028835A1,NC[C@H](O)COc1ccccc1.O=C1CCN(c2ccc(C=C3SC(=S)NC3=O)cc2)CC1>>O=C1NC(=S)SC1=Cc1ccc(N2CCC(NC[C@H](O)COc3ccccc3)CC2)cc1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05932695,COC(=O)CCCOc1cc([N+](=O)[O-])c(C(C)O)cc1OC>>COc1cc(C(C)O)c([N+](=O)[O-])cc1OCCCC(=O)O,,CO,,O,[Li+].[OH-],val
US20070225267A1,CC(C)(C)OC(=O)N1C([C@@H](OCc2ccccc2)[C@H](Cc2cc(F)cc(F)c2)N(Cc2ccccc2)Cc2ccccc2)COC1(C)C>>N[C@H](CO)[C@@H](OCc1ccccc1)[C@H](Cc1cc(F)cc(F)c1)N(Cc1ccccc1)Cc1ccccc1,,C1COCCO1,,Cl,,val
US20120010411A1,CCCCCCc1cc(-c2sc(Br)cc2CCCCCC)sc1-c1ccc(N(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1.CCCC[PH](=O)OCC>>CCCCCCc1cc(-c2sc(P(=O)(O)CCCC)cc2CCCCCC)sc1-c1ccc(N(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1,,CCOC(C)=O,,CCN(CC)CC,Cc1ccccc1,val
US04230707,COC(=O)c1sc(C)cc1N.O=C(O)c1ccc(Cl)nc1>>Cc1cc2nc3ccc(C(=O)O)cn3c(=O)c2s1,,CO,,,,val
US20060142280A1,CC(C)(C)OC(=O)n1c(C#N)ccc1-c1ccc2c(c1)C(C)(C)OC(=O)N2.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)(C)OC(=O)n1c(C#N)ccc1-c1ccc2c(c1)C(C)(C)OC(=S)N2,,Cc1ccccc1,,,,val
US20120220575A1,CC(C)(C)OC(=O)CBr.Clc1ncc2c(n1)N1CCOC[C@H]1CN2>>CC(C)(C)OC(=O)CN1C[C@@H]2COCCN2c2nc(Cl)ncc21,,CN(C)C=O,,O,[H-].[Na+],val
US20080004309A1,CCOC(=O)CN(Cc1ccc(OC)cc1OC)Cc1nc(-c2ccc(C(C)(C)C)cc2)sc1C(=O)O>>CCOC(=O)C1C(=O)c2sc(-c3ccc(C(C)(C)C)cc3)nc2CN1Cc1ccc(OC)cc1OC,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US07632791B2,C[C@H]1C[C@H](O)[C@](C)(O)C12CCCCCC2>>C[C@H]1CC(=O)[C@](C)(O)C12CCCCCC2,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20090298866A1,CC(C)Cc1cn(-c2nc(C(=O)Nc3ccccc3N)cs2)c2cc(C(F)(F)F)ccc12>>CC(C)Cc1cn(-c2nc(-c3nc4ccccc4[nH]3)cs2)c2cc(C(F)(F)F)ccc12,,CC(=O)O,O,,,val
US20100280011A1,COC(=O)C(CN)c1ccccc1.N=C(c1ccccc1)c1ccccc1>>COC(=O)C(CN=C(c1ccccc1)c1ccccc1)c1ccccc1,,ClCCl,,Cl,,val
US20090181965A1,CC(=N)NO.O=C(O)C1CCCCC12OCCO2>>Cc1noc(C2CCCCC23OCCO3)n1,,C1CCOC1,,On1nnc2ccccc21,,val
US20030100576A1,CCO.CCOC(C)=O.CCOC(OCC)OCC.Cc1ccc(S(=O)(=O)O)cc1>>CCOC(=O)[C@@H]1CCC[C@H](C(=O)OCC)C1,,CCOC(C)=O,,O,,val
US20110118230A1,C[Si](C)(C)Br.Nc1cnc(Cl)cc1-c1cc(-c2ccc(CN3CCCCC3)cc2)cnc1F>>Brc1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCCCC4)cc3)cc12,,C1COCCO1,,,,val
US07405221B2,C1CCNC1.CS(=O)(=O)c1nc(Oc2ccccn2)c(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)n1>>Clc1ccc(-c2c(Oc3ccccn3)nc(C3CCCN3)nc2-c2ccc(Cl)cc2Cl)cc1,,C1CCOC1,,,,val
US20100266504A1,Br[Mg]C1CCC1.Clc1ccc2c(n1)CCN(Cc1ccccc1)C2>>Cl.c1cc2c(nc1C1CCC1)CCNC2,,C1CCOC1,,,,val
US20090298823A1,CC(=O)N1CCN(c2ccc(N)cc2)CC1.Cc1ccc(S(=O)(=O)n2cc(C#N)c3c(NCC4CCN(C(=O)OC(C)(C)C)CC4)nc(Cl)nc32)cc1>>CC(=O)N1CCN(c2ccc(Nc3nc(NCC4CCNCC4)c4c(C#N)c[nH]c4n3)cc2)CC1,,CCCCO,,C[Si](C)(C)Cl,,val
US08835458B2,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)OCc1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,CCN=C=NCCCN(C)C,val
US06420375B1,C/C(=C\CO)c1ccc2ccccc2c1.O=S(Cl)Cl>>C/C(=C\CCl)c1ccc2ccccc2c1,,ClCCl,,,,val
US20060211697A1,Cc1ccc(Oc2ccccc2C(=N)NO)c(O)c1.O=C(c1ncc[nH]1)c1ncc[nH]1>>Cc1ccc(Oc2ccccc2-c2noc(=O)[nH]2)c(O)c1,,C1CCOC1,,,,val
US20110136764A1,CC(C)(C)[Si](C)(C)Cl.OC1CC(n2cc(I)cn2)C1>>CC(C)(C)[Si](C)(C)OC1CC(n2cc(I)cn2)C1,CN(C)c1ccncc1,ClCCl,,c1c[nH]cn1,,val
US20140243283A1,OC[C@H]1O[C@H](C/C=C/c2cccc(C#C[C@H]3O[C@H](COCc4ccccc4)[C@@H](OCc4ccccc4)[C@H](OCc4ccccc4)[C@@H]3OCc3ccccc3)c2)[C@@H](O)[C@@H](O)[C@@H]1O>>OC[C@H]1O[C@H](C/C=C/c2cccc(C#C[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)c2)[C@@H](O)[C@@H](O)[C@@H]1O,,CC#N,,C[Si](C)(C)I,,val
US04353898,CC1([C@H]2CC[C@H]3[C@@H]4CC[C@H]5CC=CC[C@]5(C)[C@H]4C(=NO)C[C@@]32C)OCCO1>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC=CC[C@]4(C)[C@H]3[C@H](N)C[C@]12C,,CCCO,,[Na],,val
US20080221192A1,O=C1Cc2ccc(C(=O)Nc3cccc(NC(=O)c4ccccc4)c3)cc2N1.O=Cc1ccc[nH]1>>O=C1Nc2cc(C(=O)Nc3cccc(NC(=O)c4ccccc4)c3)ccc2C1=Cc1ccc[nH]1,C1CCNCC1,CCO,,,,val
US20070004675A1,CCOC(=O)C(C(=O)OCC)C(Nc1ccc(Oc2ccnc3cc(-c4cn(C)cn4)sc23)c(F)c1)C(F)(F)F>>Cn1cnc(-c2cc3nccc(Oc4ccc(NC(CC(=O)O)C(F)(F)F)cc4F)c3s2)c1,,CCO,O,[Na+].[OH-],,val
US04110351,CCCCCCCC/C=C\CCCCCCCCO.O=C(O)c1ccc(Br)o1>>CCCCCCCC/C=C\CCCCCCCCOc1ccc(C(=O)O)o1,,CC(=O)O,,CN(C)C=O,[H-].[Na+],val
US20160095928A1,CC(=O)O.CC(=O)OC(C)=O.CC(=O)[O-].O=C1CCC(=O)O1>>CC(=O)O.CC(O)CO.CO.O=C(O)CCC(=O)O,,CC(=O)O,,O,,val
US20120114765A1,CC(=O)c1cc([N+](=O)[O-])c(Sc2ccc(Cl)cc2Cl)s1.O=C(OO)c1cccc(Cl)c1>>CC(=O)c1cc([N+](=O)[O-])c(S(=O)c2ccc(Cl)cc2Cl)s1,,ClCCl,,,,val
US20080306112A1,CCOC(=O)N1CCC(Nc2cc(F)ccc2N)CC1.O=C(n1ccnc1)n1ccnc1>>CCOC(=O)N1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1,,CC#N,,,,val
US20090253677A1,COC(=O)N1CC(C)(C)N(Cc2ccc(OC)cc2)S1(=O)=O>>COc1ccc(CN2C(C)(C)CNS2(=O)=O)cc1,,CO,O,Cl,[Na+].[OH-],val
US20070082912A1,CC(=O)CCC(=O)c1cc(Br)ccc1OCc1ccc(F)cc1F.Nc1cccc(-c2nc3ccccc3[nH]2)c1>>Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(-c2nc3ccccc3[nH]2)c1,Cc1ccc(S(=O)(=O)O)cc1,CCOC(C)=O,Cc1ccccc1,,,val
US04258185,CC(CC(=O)O)C(=O)c1ccc2c(c1)CCN2.NN>>CC1CC(=O)NN=C1c1ccc2c(c1)CCN2,,CCO,,Cl,O,val
US20080275046A1,CCCN(CC1CC1)C(=O)c1oc(-c2ccc(OCCCN3CCCC3C)cc2)nc1C>>CCCN(Cc1oc(-c2ccc(OCCCN3CCCC3C)cc2)nc1C)CC1CC1,,C1CCOC1,,,,val
US04554351,CC(C)C[C@@H](C(=O)N[C@@H](C)C(=O)Cc1ccccc1)N(C)C(=O)OC(C)(C)C>>CN[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)Cc1ccccc1,,O=C(O)C(F)(F)F,,,,val
US05688803,NC(=O)c1cc(Br)c([N+](=O)[O-])cc1N.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=c1[nH]c(=O)c2cc(Br)c([N+](=O)[O-])cc2[nH]1,,C1CCOC1,,,,val
US20140336166A1,C[C@@H]1COCCN1c1nc(Cl)nc2[nH]c(Br)nc12.OB(O)c1cccc2[nH]ccc12>>C[C@@H]1COCCN1c1nc(Cl)nc2[nH]c(-c3cccc4[nH]ccc34)nc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,O,[Cs+].[F-],,val
US20090029947A1,COc1ccccc1CCC(=O)O>>COc1ccccc1CCCO,,C1CCOC1,,CO,,val
US20080312282A1,II.O=C1CCOCC1.c1cscn1>>OC1(c2ncc(I)s2)CCOCC1,,C1CCOC1,ClCCl,[Li]CCCC,,val
US20150225381A1,CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1c1ccc(OCC2(C(=O)O)CC2)c(F)c1.CN>>CNC(=O)C1(COc2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)CC1,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120094981A1,N#Cc1ccc(F)cc1C(F)(F)F.O[C@H]1CC[C@H](O)CC1>>N#Cc1ccc(OC2CCC(O)CC2)cc1C(F)(F)F,,CCOCC,CS(C)=O,O,[H-].[Na+],val
US20070032515A1,CC(C)(C)OC(=O)N1CCC(COS(C)(=O)=O)CC1.COC(=O)c1ccc(OC)c(O)c1>>COC(=O)c1ccc(OC)c(OCC2CCN(C(=O)OC(C)(C)C)CC2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20020068758A1,CCn1c(C)cc(=O)c(OCc2ccccc2)c1COC.Cl>>CCn1c(C)cc(=O)c(O)c1CO.Cl,,Cl,,,,val
US20110230537A1,CON(C)C(=O)CCc1c(Cl)cc(Cl)cc1Cl>>O=CCCc1c(Cl)cc(Cl)cc1Cl,,Cc1ccccc1,,CC(C)C[AlH]CC(C)C,,val
US20040039038A1,CCOC(=O)C(=Cc1ccc(-c2cccc(CN(C)C(=O)c3ccccc3)c2)cc1)C(=O)OCC>>CCOC(=O)C(Cc1ccc(-c2cccc(CN(C)C(=O)c3ccccc3)c2)cc1)C(=O)OCC,,CO,,C1CCOC1,,val
US20050096337A1,CCOC(=O)C(C)(C)Oc1ccc(O)cc1C.FC(F)(F)c1ccc(-c2ccc(CCl)c(C3CC3)n2)cc1>>CCOC(=O)C(C)(C)Oc1ccc(OCc2ccc(-c3ccc(C(F)(F)F)cc3)nc2C2CC2)cc1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140121200A1,CC(C)(C)OC(=O)N1CCO[C@H](CNc2nc(Cl)cc3nccnc23)C1.C[Sn](C)(C)c1ccc(N2CCC(O)CC2)cc1>>CC(C)(C)OC(=O)N1CCO[C@H](CNc2nc(-c3ccc(N4CCC(O)CC4)cc3)cc3nccnc23)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20110275611A1,CC[C@@H]1COCCN1c1cc(-c2ccc(C#N)c(F)c2)nc(NC)n1.NN>>CC[C@@H]1COCCN1c1cc(-c2cc(F)c3c(N)n[nH]c3c2)nc(NC)n1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20030236250A1,CC(C)(O)CCC1(O)CCN(C(=O)OC(C)(C)C)CC1>>CC1(C)CCC2(CCNCC2)O1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110230462A1,COc1cc(B(O)O)cc(OC)c1OC.C[C@@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Br)nc12)C(=O)N1CC(C#N)C1>>COc1cc(-c2cnc3c(n2)c(C(=O)N[C@H](C)C(=O)N2CC(C#N)C2)cn3COCC[Si](C)(C)C)cc(OC)c1OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20100093694A1,CC(C)(C)N.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cccc(C(=O)O)c3)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cccc(C(=O)NC(C)(C)C)c3)cc12,,CC#N,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100130558A1,CC(C)C[C@@H](C(=O)OC(C)(C)C)N1CCOCC1.Cl>>CC(C)C[C@@H](C(=O)O)N1CCOCC1.Cl,,C1COCCO1,,,,val
US05440044,CCCCCCCCC(O)/C=C/c1cccc(Br)n1.COC(=O)c1cc(C(=O)OC)cc(C(=O)OC)c1>>CCCCCCCCC(O)/C=C/c1cccc(C(=O)c2cc(C(=O)OC)cc(C(=O)OC)c2)n1,,C1CCOC1,,[Li]CCCC,,val
US20160229872A1,CC(C)(C)OC(=O)N1CCC(O)(Cn2cnc3c(-c4ccccc4)n[nH]c3c2=O)CC1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=c1c2[nH]nc(-c3ccccc3)c2ncn1CC1(O)CCNCC1,,ClCCl,,,,val
US20040248872A1,CCOC(=O)c1sc(Nc2ccccc2)nc1C>>Cc1nc(Nc2ccccc2)sc1C(=O)O,,CC(=O)O,,CCO,[Na+].[OH-],val
US20090023935A1,CCOC(=O)[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1O>>O=C(O)[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1O,,CCO,O,[Na+].[OH-],,val
US07071201B2,Brc1cn[nH]c1.OCCOCc1ccccc1>>BrCCOCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20130217680A1,CC(C)(C)OC(=O)N1CCNCC1.O=Cc1coc2c(Br)cccc12>>CC(C)(C)OC(=O)N1CCN(Cc2coc3c(Br)cccc23)CC1,,CCOC(C)=O,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120184574A1,CC(C)OB(OC(C)C)OC(C)C.Cc1cc2c(cc1F)c(C#N)cn2C1CCC1>>Cc1cc2c(cc1F)c(C#N)c(B(O)O)n2C1CCC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20150152047A1,CCS(=O)(=O)c1c(Cl)cc(Cl)cc1CBr.[NH4+]>>CCS(=O)(=O)c1c(Cl)cc(Cl)cc1CN,,CCO,,C1CCOC1,,val
US05013741,Nc1c2c(nc3ccccc13)CCCC2.O=Cc1ccc([N+](=O)[O-])cc1>>O=[N+]([O-])c1ccc(C=Nc2c3c(nc4ccccc24)CCCC3)cc1,,Cc1ccccc1,,C1COCCN1,,val
US20150246923A1,CNN.N#CCC(=O)C1CCC1>>Cn1nc(C2CCC2)cc1N,,CCO,,,,val
US20040138195A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc(OCc2ccccc2)c2ncccc2c1>>CC(C)(C)OC(=O)Nc1cc(OCc2ccccc2)c2ncccc2c1,,C1COCCO1,,,,val
US20070197537A1,O=C(Nc1ccc(Oc2ccnc3cc(C4=CCC5(CC4)OCCO5)sc23)c(F)c1)c1ccnn(-c2ccc(F)cc2)c1=O>>O=C1CC=C(c2cc3nccc(Oc4ccc(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)c3s2)CC1,,O=C(O)C(F)(F)F,,,,val
US05753664,Cc1cnc2sc(O)cn2c1=O.O=C(c1ccc(Cl)cc1)c1ccc(CBr)cc1>>Cc1c(OCc2ccc(C(=O)c3ccc(Cl)cc3)cc2)nc2sccn2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090286790A1,CC(C)OC(=O)Cl.CC(C)[Mg]Br.COc1ccncc1>>CC(C)OC(=O)N1C=CC(=O)CC1C(C)C,,C1CCOC1,,,,val
US04931436,CCN(CC)CCCC1CCCNC1.O=C1Nc2ccccc2N(C(=O)Cl)c2ncccc21>>CCN(CC)CCCC1CCCN(C(=O)N2c3ccccc3NC(=O)c3cccnc32)C1,,CC#N,,,,val
US20160083391A1,COc1ccc(Cn2nc(N)c(C#N)c2Nc2ccccc2)cc1.OO>>COc1ccc(Cn2nc(N)c(C(N)=O)c2Nc2ccccc2)cc1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20070155721A1,CCOC(=O)c1cc2c(O)cccc2[nH]1.OCc1ccco1>>CCOC(=O)c1cc2c(OCc3ccco3)cccc2[nH]1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140113882A1,CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)[C@@H](C(O)c2ccc(F)cc2)C1>>O[C@H](c1ccc(F)cc1)C1CNCCN1,,CO,Cl,C1COCCO1,,val
US20040220261A1,CC(C)(C)[Si](O[C@@H]1CCC[C@H](CC=O)C1)(c1ccccc1)c1ccccc1.CCOP(=O)(OCC)C(CC)C(=O)OC(C)(C)C>>CCC(=CC[C@H]1CCC[C@@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C1)C(=O)OC(C)(C)C,,C1CCOC1,CCCCCC,O,[Li]CCCC,val
US20080275032A1,CCOC(=O)c1c(O)c(-c2cccs2)nn(CCC(C)(C)CC)c1=O.CS(=O)(=O)Nc1ccc(N)c(S(N)(=O)=O)c1>>CCC(C)(C)CCn1nc(-c2cccs2)c(O)c(C2=NS(=O)(=O)c3cc(NS(C)(=O)=O)ccc3N2)c1=O,,c1ccncc1,,,,val
US20090318410A1,CN(C)S(=O)(=O)c1ccc(B(O)O)cc1.COc1ccc(-c2ccc3nc(C)c(Br)n3n2)cc1OC>>COc1ccc(-c2ccc3nc(C)c(-c4ccc(S(=O)(=O)N(C)C)cc4)n3n2)cc1OC,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20040082604A1,CCOC(=O)NC(=O)C1CCNCC1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)NC(=S)C1CCNCC1,,Cc1ccccc1,,,,val
US20030229094A1,O=C(CCl)Nc1ccc(Cl)cc1.c1ccc(N2CCNCC2)nc1>>O=C(CN1CCN(c2ccccn2)CC1)Nc1ccc(Cl)cc1,,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20120214767A1,COc1ccc2c(c1)CCc1sc(N)nc1-2>>Nc1nc2c(s1)CCc1cc(O)ccc1-2,,ClCCl,,,,val
US20100316601A1,COc1c(-c2cccc(C(=O)O)c2)cc(F)cc1[N+](=O)[O-]>>O=C(O)c1cccc(-c2cc(F)cc([N+](=O)[O-])c2O)c1,,Br,,,,val
US20130196974A1,FC(F)(F)Oc1ccc2nc(Cl)cc(Cl)c2c1.O=S1(=O)CCNCc2ccccc21>>O=S1(=O)CCN(c2cc(Cl)c3cc(OC(F)(F)F)ccc3n2)Cc2ccccc21,,CCCCO,,,,val
US20090270374A1,CC(C)(C)[Si](C)(C)O[C@H]1C[C@@H](CN2C(=O)c3ccccc3C2=O)CN(C(=O)OCc2ccccc2)C1>>O=C(OCc1ccccc1)N1C[C@H](O)C[C@H](CN2C(=O)c3ccccc3C2=O)C1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05798344,CCOP(=O)(Cc1ccc(-c2nc(O)c3ccccc3n2)cc1)OCC.CI>>CCOP(=O)(Cc1ccc(-c2nc3ccccc3c(=O)n2C)cc1)OCC,,CO,,CC(C)(C)[O-].[K+],,val
US20060116515A1,CCOC(=O)CN=C(c1ccccc1)c1ccccc1.Cc1cc(Cl)nc(-n2ccnc2)n1>>CCOC(=O)C(N=C(c1ccccc1)c1ccccc1)c1cc(C)nc(-n2ccnc2)n1,,CS(C)=O,,O,[H-].[Na+],val
US20140275172A1,CCCc1cc2cc(C(=O)N(C)C)cc(COc3ccc(CCC(=O)OCC)c(C)c3C)c2o1>>CCCc1cc2cc(C(=O)N(C)C)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1,,C1CCOC1,O,[Li+].[OH-],,val
US20160206616A1,CC(C)(C)OC(=O)N1CC(F)(F)C[C@H]1C=O.COC(=O)C(C)=P(c1ccccc1)(c1ccccc1)c1ccccc1>>COC(=O)C(C)=C[C@@H]1CC(F)(F)CN1C(=O)OC(C)(C)C,,ClCCl,,,,val
US04873255,Cc1c(OCc2ccccc2)ccc2c1OC(C)(COc1ccc([N+](=O)[O-])cc1)CC2=O>>Cc1c(O)ccc2c1OC(C)(COc1ccc([N+](=O)[O-])cc1)CC2=O,,O,,CC(=O)O,Cl,val
US07001910B1,CNCCO.Clc1ccnc(Cl)n1>>CN(CCO)c1cc(Cl)ncn1,,CCO,O,,,val
US20070287703A1,CCC(c1nc2n(c(=O)c1Cc1ccccc1)CCS2)N1C(=O)c2ccccc2C1=O>>CCC(N)c1nc2n(c(=O)c1Cc1ccccc1)CCS2,,CCO,,NN,O,val
US20040157804A1,COc1c2c(c(O[Si](C(C)C)(C(C)C)C(C)C)c3ncccc13)C(=O)N(Cc1ccc(F)cc1)C2=O>>COc1c2c(c(O)c3ncccc13)C(=O)N(Cc1ccc(F)cc1)C2O,,ClCCl,,CO,[BH4-].[Na+],val
US20090093524A1,BrC(Br)(Br)Br.OCc1c(C(F)(F)F)nnn1-c1c(Cl)cccc1Cl>>FC(F)(F)c1nnn(-c2c(Cl)cccc2Cl)c1CBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050070592A1,CI.Cc1c(-c2ccccc2)[nH]c2ccc(Br)cc12>>Cc1c(-c2ccccc2)n(C)c2ccc(Br)cc12,,CN(C)C=O,,,,val
US20090042917A1,CCC(C)c1c(Cl)nc(S(C)(=O)=O)nc1NCC(F)(F)F.NN>>CCC(C)c1c(Cl)nc(NN)nc1NCC(F)(F)F,,CCO,,O,,val
US20090023731A1,N[C@H]1CC[C@H](O)CC1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)NC1CCC(O)CC1,,CN(C)C=O,,,,val
US05104867,C=O.COc1ccc(CSC[C@@H]2CCCN2)cc1>>COc1ccc(CSC[C@@H]2CCCN2C)cc1,,CC#N,,[BH3-]C#N.[Na+],,val
US20140371199A1,CN1CCN(C(=O)c2ccc(-c3cn4c(Br)cnc4cn3)cc2)CC1.N#Cc1ccc(B(O)O)cc1>>CN1CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(C#N)cc5)cnc4cn3)cc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US03951981,CN1c2ccccc2NC(=O)c2cscc21.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CN1c2ccccc2NC(=S)c2cscc21,,c1ccncc1,,,,val
US20040058894A1,CCCCCCCCCc1ccc(CN)cc1.C[Si](C)(C)CCl>>CCCCCCCCCc1ccc(CNC[Si](C)(C)C)cc1,,CS(C)=O,,,,val
US20160122344A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCCO)cc1CC2C(C)(C)COC>>COCC(C)(C)C1Cc2cc(OCCCO)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21,,C1CCOC1,CCO,Cl,[Li+].[OH-],val
US05696127,CCOC(C)=O.Cc1ccccc1.Nc1ccc(Br)cc1F.O=[N+]([O-])c1cccc(B(O)O)c1>>CC1=CC(C)(C)Nc2c(F)cc(-c3cccc([N+](=O)[O-])c3)cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US05223498,CI.NC(=S)Nc1ccccc1N1CCOCC1>>CSC(=N)Nc1ccccc1N1CCOCC1.I,,CO,,,,val
US20100305070A1,BrP(Br)Br.COc1cccc2cc(C=O)oc12>>COc1cccc2cc(CBr)oc12,,CCO,,[BH4-].[Na+],,val
US20110245205A1,Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3(N)COC3)s2)c1.NS(N)(=O)=O>>Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3(NS(N)(=O)=O)COC3)s2)c1,,C1COCCO1,CCOC(C)=O,,,val
US20100292238A1,COc1ccc(C2=C(c3ccc(O)cc3)C(=O)C(C)(C)O2)cc1.ClCc1nc2ccccn2c1Cl>>COc1ccc(C2=C(c3ccc(OCc4nc5ccccn5c4Cl)cc3)C(=O)C(C)(C)O2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20080146661A1,O=C(CCC1CCCC1)Nc1cc2c(cc1[N+](=O)[O-])C(Nc1ccc(C(F)(F)F)cc1)CC2>>Nc1cc2c(cc1NC(=O)CCC1CCCC1)CCC2Nc1ccc(C(F)(F)F)cc1,[Ni],CO,,,,val
US20130066089A1,CCOC(=O)CCCC(=O)CCC1CCC(C)O1>>CCCCCCCCCCCC(=O)OCC,,O,,[H][H],,val
US20130131017A1,CC(C)(C)OC(=O)NCc1ccc2c(c1)B(O)OC2(C)C.Cl>>CC1(C)OB(O)c2cc(CN)ccc21.Cl,,CO,,,,val
US20020077486A1,Nc1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)s2)cc1.O=C1OC(=O)c2ccccc21>>O=C(NS(=O)(=O)c1ccc(Cl)s1)c1ccc(N2C(=O)c3ccccc3C2=O)cc1,,CN(C)C=O,,,,val
US20100113774A1,CC(C)(C)OC(=O)Cn1c(=O)[nH]c2cccnc2c1=O.COc1cc(OC)c(NC(=O)CBr)cc1Cl>>COc1cc(OC)c(NC(=O)Cn2c(=O)n(CC(=O)OC(C)(C)C)c(=O)c3ncccc32)cc1Cl,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20080176829A1,C=O.C[C@@H]1COc2ccc3c(ccn3S(=O)(=O)c3ccccc3)c2CN1>>C[C@@H]1COc2ccc3c(ccn3S(=O)(=O)c3ccccc3)c2CN1C,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20130267516A1,COc1cc([C@@H](C)N[C@H]2CC[C@@H](c3ccc(I)nc3)C2)ccc1F.NC(=O)C1CCNCC1>>COc1cc([C@@H](C)N[C@H]2CC[C@@H](c3ccc(NC(=O)C4CCNCC4)nc3)C2)ccc1F,I[Cu]I,CN(C)C=O,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US05741811,O=Cc1cc(-c2ccc(-c3cccs3)s2)sc1CO>>OCc1cc(-c2ccc(-c3cccs3)s2)sc1CO,,CO,,[BH4-].[Na+],,val
US20130217666A1,CC(=O)Cl.COC(=O)c1nc2c(s1)C(N=[N+]=[N-])COc1ccc(Br)cc1-2>>COC(=O)c1nc2c(s1)C(NC(C)=O)COc1ccc(Br)cc1-2,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050026987A1,CCO.CCOC(=O)c1cc2cc(N(CC)C(C)=O)ccc2[nH]1>>CCc1c(C(=O)O)[nH]c2ccc(N(CC)C(C)=O)cc12,,O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090253656A1,CN(C)CC(=O)O.COc1ccc(/C(C#N)=C/c2ccc(N3CCC(O)CC3)s2)cc1OC.Cc1ccc(S(=O)(=O)O)cc1>>COc1ccc(/C(C#N)=C/c2ccc(N3CCC(OC(=O)CN(C)C)CC3)s2)cc1OC.Cc1ccc(S(=O)(=O)O)cc1,,Cc1ccccc1,,Cl,O,val
US20090118305A1,CNC(=O)c1cccc2nc(-c3cc(-c4cnn(C5CCN(C(=O)OC(C)(C)C)CC5)c4)cnc3N)oc12>>CNC(=O)c1cccc2nc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)oc12,,CC(C)O,,Cl,,val
US20090215778A1,CCc1ccc(C(=O)C(C)C(=O)C(F)(F)F)cc1.C[C@@H]1CN([C@@H](CO)c2ccccc2)CCN1C(=O)c1c[nH]nc1N>>CCc1ccc(-c2nc3c(C(=O)N4CCN([C@@H](CO)c5ccccc5)C[C@H]4C)cnn3c(C(F)(F)F)c2C)cc1,,ClCCl,,CCOC(C)=O,CO,val
US20080139540A1,CO.COc1ccc2nccc(N3CCC4(CC3)C[C@@H](O)[C@@H](NC(=O)OC(C)(C)C)C4)c2n1>>COc1ccc2nccc(N3CCC4(CC3)C[C@H](N)[C@H](O)C4)c2n1.O=C([O-])[O-],,CO,,C1COCCO1,Cl,val
US20150299189A1,COc1ccc2c(-c3ccccc3)nccc2c1>>Oc1ccc2c(-c3ccccc3)nccc2c1,,CCOC(C)=O,,Br,O=C([O-])O.[Na+],val
US20080039437A1,C=CCBr.CC(C)(C)OC(=O)N1CCC(C(=O)NS(=O)(=O)Cc2ccccc2)CC1>>C=CCN(C(=O)C1CCN(C(=O)OC(C)(C)C)CC1)S(=O)(=O)Cc1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US04260751,CCOC=C(C(=O)OCC)C(=O)OCC.NNc1ccccc1[N+](=O)[O-]>>CCOC(=O)c1cnn(-c2ccccc2[N+](=O)[O-])c1O,,CCO,,,,val
US20150329549A1,CC(=O)Nc1ccc(Cl)cc1C1CC1>>Nc1ccc(Cl)cc1C1CC1,,CCOC(C)=O,O,Cl,,val
US20050176750A1,CCBr.COc1cc(C2C(C#N)=COC3C4=CC=NC4=CC=C32)cc(Br)c1OC>>CCn1ccc2c3c(ccc21)C(c1cc(Br)c(OC)c(OC)c1)C(C#N)=CO3,,C1CCOC1,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US06218431B1,CCCCCc1c(CO)nc(C(C)C)c(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c1-c1ccc(F)cc1.CI>>CCCCCc1c(COC)nc(C(C)C)c(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c1-c1ccc(F)cc1,,C1CCOC1,O,[H-].[Na+],,val
US05434124,CS(=O)(=O)Oc1ccccc1S(=O)(=O)Cl.N>>CS(=O)(=O)Oc1ccccc1S(N)(=O)=O,,C1CCOC1,,,,val
US20060079553A1,CCOC(=O)c1cnc(N)s1.Cc1ccc2nc(OCc3ccccc3Cl)cc(C(=O)O)c2c1>>CCOC(=O)c1cnc(NC(=O)c2cc(OCc3ccccc3Cl)nc3ccc(C)cc23)s1,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,CCN=C=NCCCN(C)C,Cl,val
US04021441,NC1CC1.O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1Cl)=NCc1nnc(CCl)n1-2>>O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1Cl)=NCc1nnc(CNC3CC3)n1-2,,C1CCOC1,,[I-].[K+],,val
US08318928B2,CC(C)(C)c1csc(N)n1.COc1cccc(/C=C/c2nc3sccn3c2C(=O)O)c1OCC(C)(C)C>>COc1cccc(/C=C/c2nc3sccn3c2C(=O)Nc2nc(C(C)(C)C)cs2)c1OCC(C)(C)C,CN(C)c1ccncc1,CN(C)C=O,ClCCl,CCN=C=NCCCN(C)C,Cl,val
US20130072470A1,Cc1ccc(S(=O)(=O)n2ccc3c2ncc2ncc([C@H]4CN(C(=O)NCC(F)F)C[C@H]4C)n23)cc1>>C[C@@H]1CN(C(=O)NCC(F)F)C[C@@H]1c1cnc2cnc3[nH]ccc3n12,,C1COCCO1,,[Na+].[OH-],,val
US07338972B1,C[C@@H](Cn1ncc2ccc(C(N)=O)cc21)N=[N+]=[N-]>>C[C@H](N)Cn1ncc2ccc(C(N)=O)cc21,[Pd],CCO,,,,val
US05763489,COc1cccc2c1CCC(CO)C2.O=C1NC(=O)c2ccccc21>>COc1cccc2c1CCC(CN1C(=O)c3ccccc3C1=O)C2,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150218131A1,CCOC(=O)C(C=O)C=O.NNc1ncc(Cl)cn1>>CCOC(=O)c1cnn(-c2ncc(Cl)cn2)c1,,CCO,,C1COCCO1,Cl,val
US20130261107A1,O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccc(OCc2nc3c(o2)CNCC3)cc1>>O=C(N1CCc2nc(COc3ccccc3)oc2C1)C(F)(F)F,,ClCCl,,CCN(CC)CC,O=C([O-])[O-].[Na+].[Na+],val
US20070106095A1,CCOC(=O)c1cc2ccc(C(CC)(CC)c3ccc(OCC(=O)C(C)(C)C)c(C)c3)cc2o1>>CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1ccc2cc(C(=O)O)oc2c1,,C1CCOC1,,CO,[Na+].[OH-],val
US20090170921A1,COc1ccc(Br)c(N)c1NC(=O)c1ccc(C(C)C)cc1>>COc1ccc(Br)c2nc(-c3ccc(C(C)C)cc3)[nH]c12,,CC(=O)O,,CCOC(C)=O,,val
US20080009515A1,CCOC(=O)c1cnc(Cl)c2c(COc3cc(-c4nnc(Cc5ccc(Cl)cc5)o4)ccc3C)csc12.N>>CCOC(=O)c1cnc(N)c2c(COc3cc(-c4nnc(Cc5ccc(Cl)cc5)o4)ccc3C)csc12,,CC(C)O,,,,val
US20140336380A1,CO.COc1ccc2cccc(CC[N+]34CN5CN(CN(C5)C3)C4)c2c1.O=[N+]([O-])c1ccc(S(=O)(=O)[O-])cc1>>COc1ccc2cccc(CCN)c2c1.O=C=O,,CO,,Cl,,val
US20080207455A1,CCC(=O)C(CCC(C)CC(C)(C)C)C(=O)OC.Cc1nnc(N)[nH]1>>CCc1nc2nc(C)nn2c(O)c1CCC(C)CC(C)(C)C,,Cc1cc(C)cc(C)c1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100113467A1,O=C(Nc1cc([N+](=O)[O-])ccn1)C1CC1.O=C(O)c1nccc2cc(O)ccc12>>O=C(O)c1nccc2cc(Oc3ccnc(NC(=O)C4CC4)c3)ccc12,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140235660A1,C=CC(=O)OC(C)(C)C.COc1ccc(-c2sc3cc(OC)ccc3c2Oc2ccc(Br)cc2)cc1>>COc1ccc(-c2sc3cc(OC)ccc3c2Oc2ccc(/C=C/C(=O)OC(C)(C)C)cc2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,O,CCN(CC)CC,,val
US20050070582A1,Cc1cc(C)cc(Oc2ccc(CO)cc2S(=O)(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1.Cl>>Cc1cc(C)cc(Oc2ccc(CO)cc2S(=O)(=O)N2CCNCC2)c1.Cl,,C1COCCO1,,,,val
US04456464,C=[N+]=[N-].CC(Oc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-])P(C)(=O)O>>COP(C)(=O)C(C)Oc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],,CCOCC,,,,val
US20150232478A1,COC(=O)c1cnccc1O.O=C1CCC(=O)N1Br>>COC(=O)c1cncc(Br)c1O,,CC#N,,CC(=O)O,,val
US20060004012A1,CC(C)=C[Mg]Br.COC(=O)C(=Cc1ccc(OCc2cccc(OC)c2)cc1)C(=O)OC>>COC(=O)C(C(=O)OC)C(C=C(C)C)c1ccc(OCc2cccc(OC)c2)cc1,,C1CCOC1,,,,val
US20120141471A1,O=c1c2cccn2c2ccccc2n1CCCCl.OC1(c2ccc(Cl)cc2)CCNCC1>>O=c1c2cccn2c2ccccc2n1CCCN1CCC(O)(c2ccc(Cl)cc2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090281331A1,CC(C)(C)OC(=O)N1C[C@H]2[C@@H](C1O)C2(C)C.C[Si](C)(C)C#N>>CC(C)(C)OC(=O)N1C[C@H]2[C@@H]([C@H]1C#N)C2(C)C,,Cc1ccccc1,,,,val
US20090130165A1,COC(=O)CSCC(=O)c1ccc2[nH]c(=O)[nH]c2c1>>O=C(O)CSCC(=O)c1ccc2[nH]c(=O)[nH]c2c1,,CO,,[Na+].[OH-],,val
US05476933,C=CC(C)=O.CC(C)(C)[Si](C)(C)ON>>C=CC(C)=NO[Si](C)(C)C(C)(C)C,,ClCCl,,,,val
US20100004301A1,Cc1cc(C)cc(-c2cc(-c3nc4cc(C)ccc4o3)cc(Br)c2NC(=O)C(F)(F)F)c1>>Cc1cc(C)cc(-c2cc(-c3nc4cc(C)ccc4o3)cc(Br)c2N)c1,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US20120323006A1,COC(=O)[C@@H](N)CNC(=O)OC(C)(C)C.ClCCN(CCCl)Cc1ccccc1>>COC(=O)[C@H](CNC(=O)OC(C)(C)C)N1CCN(Cc2ccccc2)CC1,,CCN(C(C)C)C(C)C,,Cl,,val
US03963742,CCCCCCCBr.Cn1nc(-c2ccccc2)c(OCCO)c1-c1ccccc1>>CCCCCCCOCCOc1c(-c2ccccc2)nn(C)c1-c1ccccc1,,O,,CN(C)C=O,[H-].[Na+],val
US20150057277A1,Nc1ccc(Oc2ccc3nccnc3c2)cc1.O=C(O)c1cccc(F)c1>>O=C(Nc1ccc(Oc2ccc3nccnc3c2)cc1)c1cccc(F)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04673684,COCCOCOc1c(OC)cc(C=CC=CC(=O)N2CCSC2)cc1OC.c1ccc(C(OCCN2CCNCC2)c2ccccc2)cc1>>COCCOCOc1c(OC)cc(C=CC=CC(=O)N2CCN(CCOC(c3ccccc3)c3ccccc3)CC2)cc1OC,,CN(C)C=O,,,,val
US20090247538A1,CC(C)(C)OC(=O)NC1CCN(c2ccnc3[nH]ccc23)CC1>>NC1CCN(c2ccnc3[nH]ccc23)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05446010,Cc1ccccc1C(=O)Cl.Nc1ccccc1>>Cc1ccccc1C(=O)Nc1ccccc1,,c1ccncc1,,[Ca+2].[Cl-].[Cl-],,val
US20100041658A1,CCc1ccc(Oc2ccc([N+](=O)[O-])cc2C(F)(F)F)c(OC)c1>>CCc1ccc(Oc2ccc(N)cc2C(F)(F)F)c(OC)c1,[Pd],C1CCOC1,,,,val
US05585385,CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ncccc2c(=O)n1C>>CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2c(c(=O)n1C)CCCN2,[Pd],CO,,,,val
US20150203505A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCc1c(C(=O)O)[nH]c2c(Br)cc3c(c12)CCO3>>CC(C)(C)OC(=O)NCCc1c(C(=O)O)[nH]c2c(Br)cc3c(c12)CCO3,,O,,C1CCOC1,O=C([O-])O.[Na+],val
US20040063714A1,Clc1cc(-c2cccs2)c(Cl)nn1.NNC(=O)c1ccccc1F>>Fc1ccccc1-c1nnc2cc(-c3cccs3)c(Cl)nn12,,Cc1ccc(C)cc1,,CCN(CC)CC,Cl,val
US20080032972A1,BrP(Br)Br.CC(O)c1cc(F)c(F)cc1F>>CC(Br)c1cc(F)c(F)cc1F,,O,,ClCCl,,val
US20050004134A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc(O)nn1>>O=c1ccc(OS(=O)(=O)C(F)(F)F)n[nH]1,,CCOC(C)=O,c1ccncc1,CO,,val
US20020107273A1,CC(C)(C)OC(=O)NOC(=O)OC(C)(C)C.CCc1nc2cc(Cl)c(Cl)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1>>CCc1nc2cc(Cl)c(Cl)cc2n1-c1ccc(CCN(O)C(=O)NS(=O)(=O)c2ccc(C)cc2)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150011773A1,BrCc1ccc(OCc2ccccc2)cn1.CC(C)(C)OC(=O)N[C@@H](CCC(C(=O)OCc1ccccc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@@H](CCC(Cc1ccc(OCc2ccccc2)cn1)(C(=O)OCc1ccccc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20090286768A1,C[Mg]Br.O=C(c1ccccc1)c1ccc(Br)cc1>>CC(O)(c1ccccc1)c1ccc(Br)cc1,,C1CCOC1,,,,val
US20130261122A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)c1ccc(Br)c(C(F)(F)F)c1>>COC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)c(C(F)(F)F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CS(C)=O,CC(=O)[O-].[K+],,val
US20150238471A1,Cc1nc(-n2cccc2)c(C)c(C)c1OCc1ccccc1>>Cc1nc(-n2cccc2)c(C)c(C)c1O,[Pd],CO,,,,val
US20110294776A1,CC(C)(C)OC(=O)N1CCN2CC(c3cc(Br)c4c(N)ncnn34)OCC2C1.Cc1c2ccc(B3OC(C)(C)C(C)(C)O3)cc2nn1Cc1ccccc1>>Cc1c2ccc(-c3cc(C4CN5CCNCC5CO4)n4ncnc(N)c34)cc2nn1Cc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20100120757A1,COc1ccc(C2=NN(C3CCN(C(=O)CCl)CC3)C(=O)C2(C)C)cc1OC.O=C1COCC(=O)N1>>COc1ccc(C2=NN(C3CCN(C(=O)CN4C(=O)COCC4=O)CC3)C(=O)C2(C)C)cc1OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05814407,C=CC(=O)Cl.CCCCCCCCCCCCCCN[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O>>C=CC(=O)N(CCCCCCCCCCCCCC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O,,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US06174901B1,CC(C)(C)OC(=O)N[C@H](CO)Cc1ccccc1.Cc1cccc(-c2cc(=O)[nH]cc2-c2ccncc2)c1>>Cc1cccc(-c2cc(OC[C@@H](N)Cc3ccccc3)ncc2-c2ccncc2)c1,,CO,ClCCl,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070043013A1,CC(C)(C)OC(=O)N[C@@H]1CCCC[C@@H]1CN1CC(Oc2ccc(Cl)cc2)C1>>N[C@@H]1CCCC[C@@H]1CN1CC(Oc2ccc(Cl)cc2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030036557A1,CS(=O)(=O)c1ccc(C2=NC(O)(C(F)(F)F)CN2c2ccc(F)cc2)cc1>>CS(=O)(=O)c1ccc(-c2nc(C(F)(F)F)cn2-c2ccc(F)cc2)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120258953A1,CSC1CCN(C(=O)OC(C)(C)C)CC1.Cl>>CSC1CCNCC1.Cl,,C1COCCO1,CO,,,val
US20080171771A1,CC(C)(C)S(=O)N=C(c1ccc(F)c(Br)c1)c1ccccc1C#N.COc1ccc(Br)cc1C>>COc1ccc(C2(c3ccc(F)c(Br)c3)N=C(N)c3ccccc32)cc1C,,C1CCOC1,CCOCC,II,[Mg],val
US20040138271A1,O=C1CCC(=O)N1Br.O=Cc1cccc(F)c1O>>O=Cc1cc(Br)cc(F)c1O,,CC#N,CCOC(C)=O,,,val
US05102905,CC1(C)COC(c2ccc(S(=O)(=O)C[N+](=O)[O-])s2)(C(C)(C)C)OC1>>CC(C)(C)C(=O)c1ccc(S(=O)(=O)C[N+](=O)[O-])s1,,CCO,,O,O=C(O)C(F)(F)F,val
US20120094972A1,BrCCOCCBr.CC(=O)N1CC(C)(C)c2ccc(N)cc21>>CC(=O)N1CC(C)(C)c2ccc(N3CCOCC3)cc21,,CO,O,O=C([O-])[O-].[Na+].[Na+],,val
US04666915,CCOC(=O)c1cnc(SC)[nH]c1=O.COc1cccc(N)c1>>CCOC(=O)c1cnc(Nc2cccc(OC)c2)[nH]c1=O,,CCO,,,,val
US20150031708A1,COc1cc(B2OC(C)(C)C(C)(C)O2)cc(C)n1.Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1Cl>>COc1cc(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)ccc2C)cc(C)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US04895860,N#CCc1ccc2c(c1)CCC2.NO>>NC(Cc1ccc2c(c1)CCC2)=NO,,CO,,Cl,C[O-].[Na+],val
US20100063054A1,BrCCOC1CCCCO1.N#Cc1cc(Br)ccc1O>>N#Cc1cc(Br)ccc1OCCOC1CCCCO1,,CN(C)C=O,ClCCl,[H-].[Na+],,val
US20150218156A1,O=c1c(Br)nn(CC(F)(F)c2ccccc2)c(=O)n1COCc1ccccc1.OCc1ccccc1>>O=c1c(OCc2ccccc2)nn(CC(F)(F)c2ccccc2)c(=O)n1COCc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20140094474A1,C[C@H](N)Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1.O=C(O)c1cn2c(n1)CCCC2>>C[C@@H](Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1)NC(=O)c1cn2c(n1)CCCC2,,O,,CN(C)C=O,,val
US06329370B1,C#CCOCCOCCOC.COc1ccc2c(Cc3c(Cl)cncc3Cl)nncc2c1OS(=O)(=O)C(F)(F)F>>COCCOCCOCC#Cc1c(OC)ccc2c(Cc3c(Cl)cncc3Cl)nncc12,[Cu]I,CCOCC,,CCNCC,,val
US20100105680A1,CC(=O)[C@@H]1C[C@H](CCN2CCOCC2)C1(C)C.[Li]c1ccccc1>>CC1(C)[C@@H](CCN2CCOCC2)C[C@H]1[C@](C)(O)c1ccccc1,,C1CCOC1,,,,val
US07855290B2,CN1CCN(C2CCNCC2)CC1.O=C(Oc1ccccc1)N(C(=O)Oc1ccccc1)c1cc(Oc2ccc(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)c(F)c2)ccn1>>CN1CCN(C2CCN(C(=O)Nc3cc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)c(F)c4)ccn3)CC2)CC1,,CN(C)C=O,,,,val
US20040044052A1,Cc1ccc(C)n1-c1ccc2c(c1)C[C@@H](C)N2.O=C(Cl)OCc1ccccc1>>Cc1ccc(C)n1-c1ccc2c(c1)C[C@@H](C)N2C(=O)OCc1ccccc1,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20070032530A1,Cc1cc(O)ccc1CCCCn1ccnn1.FC(F)(F)c1cccc(-c2ccc(CCl)cn2)c1>>Cc1cc(OCc2ccc(-c3cccc(C(F)(F)F)c3)nc2)ccc1CCCCn1ccnn1,,CN(C)C=O,,O,[H-].[Na+],val
US20140051676A1,COC(=O)c1ccc(CCl)o1.OCC(F)(F)F>>O=C(O)c1ccc(COCC(F)(F)F)o1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20110160206A1,CCOC(=O)c1nc2ccccc2nc1Cl.CNC>>CCOC(=O)c1nc2ccccc2nc1N(C)C,,CN(C)C=O,,CCN(CC)CC,O,val
US20030096841A1,CCN=C=O.NCc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O>>CCNC(=O)NCc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,,CC#N,,C1CCC2=NCCCN2CC1,Cl,val
US20100041658A1,CC(=O)OC(C)=O.CCc1ccc(Oc2ccc(N3CC(CN)OC3=O)cc2F)c(O)c1>>CCc1ccc(Oc2ccc(N3CC(CNC(C)=O)OC3=O)cc2F)c(O)c1,,ClCCl,O,,,val
US20060128793A1,COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CC[C@H](O)[C@@]2(C)C[C@H]1OC(C)=O.c1ccc(CN2CCNCC2)cc1>>COC[C@H]1OC(=O)/C(=C/N2CCN(Cc3ccccc3)CC2)C2=C(O)C(=O)C3=C([C@H](OC(C)=O)C[C@@]4(C)C3CC[C@@H]4O)[C@]21C,,ClCCl,,,,val
US20040103487A1,CCO.Cl.O=[N+]([O-])c1c(Br)nn(CCCO)c1NCc1ccccc1>>Cl.O=[N+]([O-])c1c(Br)nn(CC(O)CO)c1NCc1ccccc1,[Pd],,,,,val
US04778822,Cc1c(F)ccc([N+](=O)[O-])c1Cl>>Cc1c(F)ccc(N)c1Cl,Cl,O,,CC(C)O,,val
US06599917B1,O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc(Br)c(Cc2ccccc2)n1>>O=S(=O)(Oc1ccc(Br)c(Cc2ccccc2)n1)C(F)(F)F,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US05236952,COc1cc(C(=O)CBr)cc([N+](=O)[O-])c1O.Nc1ccccc1N>>COc1cc(-c2cnc3ccccc3n2)cc([N+](=O)[O-])c1O,,CO,,CC(=O)[O-].[Na+],,val
US20030105139A1,O=[N+]([O-])c1cccc(S(=O)(=O)Nc2cccnc2)c1>>Nc1cccc(S(=O)(=O)Nc2cccnc2)c1,[Pd],CCO,,CN(C)C=O,,val
US20040138249A1,BrCCCCCBr.CCOC(=O)c1c(-c2cccc(N)c2)c(C)n2c1-c1cc(OC)c(OC)cc1CC2>>CCOC(=O)c1c(-c2cccc(N3CCCCC3)c2)c(C)n2c1-c1cc(OC)c(OC)cc1CC2,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US20080221217A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CON(C)C(=O)[C@@H](Cc1cc(F)c(F)cc1F)NC(=O)OCc1ccccc1>>CON(C)C(=O)[C@@H](Cc1cc(F)c(F)cc1F)NC(=O)OC(C)(C)C,[Pd],CO,,,,val
US04439425,CCCCCCCCCCCCCCCC(=O)Cl.CCCCCCCCCCCCCCCCC(O)CSC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(=O)OC(c1ccccc1)c1ccccc1>>CCCCCCCCCCCCCCCCC(CSC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(=O)OC(c1ccccc1)c1ccccc1)OC(=O)CCCCCCCCCCCCCCC,,ClCCl,c1ccncc1,CO,ClC(Cl)Cl,val
US20040204586A1,N#Cc1c(N2CCNCC2)c2cc(F)ccc2n(Cc2ccccc2)c1=O.O=C(Cl)c1cccs1>>N#Cc1c(N2CCN(C(=O)c3cccs3)CC2)c2cc(F)ccc2n(Cc2ccccc2)c1=O,,c1ccncc1,,,,val
US05360887,CC(C)(c1ccc(O)cc1)c1ccc(O)cc1.CCN(CC)CC.N#CBr>>CC(C)(c1ccc(OC#N)cc1)c1ccc(OC#N)cc1,,CC(C)=O,,,,val
US20120101123A1,CCOC(=O)CCn1ccc2c(-c3noc(-c4cnc(OC(C)C)c(Cl)c4)n3)ccnc21>>CC(C)Oc1ncc(-c2nc(-c3ccnc4c3ccn4CCC(=O)O)no2)cc1Cl,,CC(C)O,O,[Na+].[OH-],,val
US20090042900A1,CCOC(=O)C1CCNCC1.Fc1ccccc1I>>CCOC(=O)C1CCN(c2ccccc2F)CC1,I[Cu]I,CS(C)=O,O,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US04897391,Cc1c2n(c(=O)c3cc(OC(=O)CN)cc(OC(=O)CN)c13)CCCC2.Cl.ClCCl>>Cc1c2n(c(=O)c3cc(OC(=O)CN)cc(OC(=O)CN)c13)CCCC2.Cl.Cl,,ClCCl,,,,val
US20150299204A1,CCCCc1nc2cc(C)[nH]c2c(=O)[nH]1.O=P(Cl)(Cl)Cl>>CCCCc1nc(Cl)c2[nH]c(C)cc2n1,,CC#N,,,,val
US20090197859A1,CN1CCNCC1.Cc1ccccc1C1CCN(S(=O)(=O)c2cccc(F)n2)CC1>>Cc1ccccc1C1CCN(S(=O)(=O)c2cccc(N3CCN(C)CC3)n2)CC1,,CS(C)=O,,CN(C)C(=N)N(C)C,,val
US20130172278A1,C=CCBr.Cc1sc(Br)cc1Cc1ccc(O)cc1>>C=CCOc1ccc(Cc2cc(Br)sc2C)cc1,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04689349,CCC(CCCCCl)OC.ClC1C=CCC1>>CCC(CCCCC1C=CCC1)OC,,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US07115611B2,CCOC(=O)C(C)(C)Oc1cccc(N(C)C(=O)Cc2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)c1>>Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1CC(=O)N(C)c1cccc(OC(C)(C)C(=O)O)c1,,C1CCOC1,CO,[Li+].[OH-],,val
US20130190315A1,COc1ccc(O)c(C=O)c1.Cn1ncc2c(CCl)cccc21>>COc1ccc(OCc2cccc3c2cnn3C)c(C=O)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150209445A1,CC(=O)Oc1cc2c(c3ccccc13)[C@H](CCl)CN2C(=O)OC(C)(C)C>>CC(=O)Oc1cc2c(c3ccccc13)[C@H](CCl)CN2,,C1COCCO1,,Cl,,val
US20030114469A1,CCOc1cc(C=O)ccc1OC.COC(CN)OC>>CCOc1cc(CNCC(OC)OC)ccc1OC,,CCO,,[BH4-].[Na+],,val
US20040063756A1,CC(C)(C)C(=O)Cl.CC(CC(C)(C)C)Oc1cccc2ccc(N)nc12>>CC(CC(C)(C)C)Oc1cccc2ccc(NC(=O)C(C)(C)C)nc12,,C1CCOC1,,CCN(CC)CC,,val
US20080015177A1,CC(C)(C)c1ccc(I)cc1I.COC(=O)c1ccc(N2CCNC2=O)cc1>>COC(=O)c1ccc(N2CCN(c3ccc(C(C)(C)C)cc3)C2=O)cc1,[Cu]I,C1COCCO1,,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20040143007A1,BrCC1CC1.N#CC(C#N)Cc1ccc(C(F)(F)F)cc1>>N#CC(C#N)(Cc1ccc(C(F)(F)F)cc1)CC1CC1,,CN(C)C=O,,[H-].[Na+],,val
US20160052952A1,CC(C)[Si]1(C(C)C)OC[C@H]2OC(n3ccc(NC(=O)c4ccc5c(c4)OCCO5)nc3=O)C(F)(F)[C@@H]2O[Si](C(C)C)(C(C)C)O1>>O=C(Nc1ccn(C2O[C@H](CO)[C@@H](O)C2(F)F)c(=O)n1)c1ccc2c(c1)OCCO2,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20120322808A1,CS(=O)(=O)Cl.OCC1CC2CC2N1c1cncc(Br)c1>>CS(=O)(=O)OCC1CC2CC2N1c1cncc(Br)c1,,ClCCl,,CCN(CC)CC,,val
US05539112,CC(C)(C)C(=O)Nc1ccc(-c2cc(=O)c3c(NCCCCl)c(F)cc(F)c3o2)cc1F.[N-]=[N+]=[N-]>>CC(C)(C)C(=O)Nc1ccc(-c2cc(=O)c3c(NCCCN=[N+]=[N-])c(F)cc(F)c3o2)cc1F,,CN(C)C=O,,O,,val
US20070082912A1,CCOC(=O)c1cccc(-n2c(C)ccc2-c2cc(S(C)(=O)=O)ccc2OCc2ccc(Cl)cc2)c1>>Cc1ccc(-c2cc(S(C)(=O)=O)ccc2OCc2ccc(Cl)cc2)n1-c1cccc(C(=O)O)c1,,CCOC(C)=O,,CCO,,val
US05032594,CCCn1c(=O)c2c(N)n(CC(=O)c3cccc(OC)c3)nc2n(Cc2ccccc2)c1=O>>CCCn1c(=O)c2c(nn3cc(-c4cccc(OC)c4)[nH]c23)n(Cc2ccccc2)c1=O,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060153918A1,C#CCN[C@@H]1CCc2ccccc21>>C#CCN[C@@H]1CCc2ccccc21,,O,,CS(=O)(=O)O,,val
US20040209857A1,C=CCC(C(=O)O)c1ccc(CNC(=O)OC(C)(C)C)cc1.CO>>C=CCC(C(=O)OC)c1ccc(CN)cc1,,CCOCC,,Cl,,val
US20040138065A1,N#CC(C#N)Cc1ccc(C(F)(F)F)cc1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>N#CC(C#N)(Cc1ccc(C(F)(F)F)cc1)CC(F)(F)F,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04096142,CC(=O)OC[C@]12CC[C@H](OC(C)=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](OC(=O)C(C)(C)C)CC[C@]12O>>C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@@]43CO)[C@@]1(O)CC[C@@H]2O,,CCOC(C)=O,,CC(=O)O,[K+].[OH-],val
US06235789B1,COc1cc(CCC(=O)O)cc(OC)c1OC>>COc1cc2c(c(OC)c1OC)C(=O)CC2,,O,,,,val
US20150376179A1,CCOC(=O)N1CCC[C@@H](O)CC1.Cc1ccc(S(=O)(=O)Cl)cc1>>CCOC(=O)N1CCC[C@@H](OS(=O)(=O)c2ccc(C)cc2)CC1,,c1ccncc1,,,,val
US05929085,O=C1NCC(=O)N2Cc3cc([N+](=O)[O-])ccc3CC12>>O=[N+]([O-])c1ccc2c(c1)CN1CCNCC1C2,,C1CCOC1,,B,,val
US20100016319A1,C1COCCN1.COC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2ccnc(Cl)n2)c1>>COC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2ccnc(N3CCOCC3)n2)c1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20110009454A1,COc1cccc(C=O)c1F.NO>>COc1cccc(CN)c1F,[Pd],CCO,O,Cl,Cl,val
US20150210697A1,CC(CCO)c1cc(C#N)cc(NC(=O)OC(C)(C)C)c1Cl>>CC(CCO)c1cc(C#N)cc(N)c1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150353505A1,C#CC(=O)OCC.COc1cccc(N)c1.C[Si](C)(C)N=[N+]=[N-]>>CCOC(=O)c1cn(-c2cccc(OC)c2)nn1,,CC#N,,CC(C)CCON=O,,val
US20020042430A1,COc1cc(N)c(Cl)cc1C(=O)OCC1CCN(C(=O)OC(C)(C)C)CC1>>COc1cc(N)c(Cl)cc1C(=O)OCC1CCNCC1,,C1CCOC1,Cl,N,,val
US20120142659A1,CCC[C@@H](CN1CCC(O)CC1)NC.O=C(Cl)c1ccc(Cl)cc1>>CCC[C@@H](CN1CCC(O)CC1)N(C)C(=O)c1ccc(Cl)cc1,,ClCCl,,,,val
US20120315291A1,CCCCOc1nc(N)c2nc(OC)n(CCCN3CCN(CCO)CC3)c2n1>>CCCCOc1nc(N)c2[nH]c(=O)n(CCCN3CCN(CCO)CC3)c2n1,,C1COCCO1,CO,Cl,,val
US20080176832A1,Cc1noc(-c2ccc(-n3cc4c(n3)CCN(C(=O)OC(C)(C)C)CC4)cc2)n1>>Cc1noc(-c2ccc(-n3cc4c(n3)CCNCC4)cc2)n1,,CO,ClCCl,O=C(O)C(F)(F)F,,val
US20060247222A1,O=Cc1ccccc1.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO>>OC[C@@H]1OC(c2ccccc2)O[C@H]([C@H](O)CO)[C@@H]1O,,Cl,O,,,val
US20090186900A1,C#Cc1ccccc1.COc1ccc(-c2ccccc2)cc1I>>COc1ccc(-c2ccccc2)cc1C#Cc1ccccc1,,C1CCOC1,O,CC#N,CCN(CC)CC,val
US20130157980A1,Cc1cccc2c(C3=C(c4nc(N5CCN(C(=O)OC(C)(C)C)C6(CC6)C5)cc5ccccc45)C(=O)N(CO)C3=O)c[nH]c12>>Cc1cccc2c(C3=C(c4nc(N5CCNC6(CC6)C5)cc5ccccc45)C(=O)N(CO)C3=O)c[nH]c12,,ClCCCl,,O=C(O)C(F)(F)F,,val
US20080275043A1,CC(C)Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.O=C1C(Cc2c(Cl)cc(OS(=O)(=O)C(F)(F)F)cc2Cl)CCN1C1CCCCC1>>CC(C)Cn1cc(-c2cc(Cl)c(CC3CCN(C4CCCCC4)C3=O)c(Cl)c2)cn1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20150291597A1,C#CCNc1nc(NCCC(=O)OCC)nc(N(C)OC)n1>>C#CCNc1nc(NCCC(=O)O)nc(N(C)OC)n1,,C1CCOC1,,Cl,[NH4+].[OH-],val
US20160237090A1,CC(C)(C)OC(=O)N1CCn2nncc2C1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCn2nnc(Br)c2C1,,CC#N,,,,val
US06008230,CCOC(=O)c1cnc2c(N)cccc2c1Cl>>CCOC(=O)c1cnc2c(N)cccc2c1,[Pd],C1COCCO1,,CCN(CC)CC,[H][H],val
US04675328,Cl.O=C(c1ccc(OCC2CO2)cc1)c1ccc([N+](=O)[O-])cc1.c1ccc(-c2ccncc2)cc1>>O=C(c1ccc(OCC(O)C[n+]2ccc(-c3ccccc3)cc2)cc1)c1ccc([N+](=O)[O-])cc1.[Cl-],,C1COCCO1,O,,,val
US05180733,CC#N.COc1ccc2c(c1)CCC=C2C#N>>COc1ccc2c(c1)CCC(CC#N)C2C#N,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US04272540,CO[C@]12[C@H]3Cc4ccc(O)cc4[C@@]1(CCN3CC1CC1)CC(=O)C[C@H]2C.Cl>>CO[C@]12[C@H]3Cc4ccc(O)cc4[C@@]1(CCN3CC1CC1)CC(O)C[C@H]2C.Cl,,CO,,[Na+].[OH-],,val
US20020151715A1,O=C(O)c1cn(-c2ccc(Cl)c(Cl)c2)cn1>>OCc1cn(-c2ccc(Cl)c(Cl)c2)cn1,,CO,,,,val
US20060074128A1,COC(=O)c1ccc(-c2cc3cc(OC)ccc3o2)cc1>>O=C(O)c1ccc(-c2cc3cc(O)ccc3o2)cc1,,O,,Cl,c1ccncc1,val
US04383999,COCCCCBr.O=C(c1ccccc1)c1ccccc1>>COCCCCC(O)(c1ccccc1)c1ccccc1,,CCOCC,,[Mg],,val
US05658943,Brc1ccc2c(c1)OCO2.O=Cc1ccc2c(c1)OCO2>>OC(c1ccc2c(c1)OCO2)c1ccc2c(c1)OCO2,,C1CCOC1,,O,[Li]CCCC,val
US20070185171A1,CC1(C)CN(S(C)(=O)=O)c2cc([N+](=O)[O-])ccc21>>CC1(C)CN(S(C)(=O)=O)c2cc(N)ccc21,[Zn],C1CCOC1,,CC(=O)O,,val
US20060058553A1,CCOC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)cc1>>CCOC(=O)c1ccc(-c2cccc(N)c2)cc1,[Pd],,,,,val
US20040053979A1,C=CCCOCC(=O)OCC.O=Cc1ccc2c(ccn2S(=O)(=O)c2ccccc2)c1>>C=CCCOC(C(=O)OCC)C(O)c1ccc2c(ccn2S(=O)(=O)c2ccccc2)c1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20100120863A1,CC(C)(C)OC(=O)N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)C4CC4)nc3C2)CO[C@@H]1c1cc(F)ccc1F.O=C(O)C(F)(F)F>>N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)C4CC4)nc3C2)CO[C@@H]1c1cc(F)ccc1F.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20110117125A1,CN1CCNCC1.OCC1CO1>>CN1CCN(CC(O)CO)CC1,,ClCCl,c1ccccc1,,,val
US20160168139A1,Nc1ccc2c(c1)Sc1cccc(-c3cc(N4CCOCC4)cc(=O)[nH]3)c1S2.O=C(Cl)CCl>>O=C(CCl)Nc1ccc2c(c1)Sc1cccc(-c3cc(N4CCOCC4)cc(=O)[nH]3)c1S2,,CO,ClCCl,CCN(CC)CC,Cl,val
US20090062396A1,COCOc1cc(C)c(F)cc1C(C)(C)C.O=C=O>>COCOc1c(C(C)(C)C)cc(F)c(C)c1C(=O)O,,C1CCOC1,,[Li]CCCC,,val
US20100249123A1,CC(C)(C#N)c1ccc(N)cc1.COc1ccc(C(=O)Cl)cc1OC>>COc1ccc(C(=O)Nc2ccc(C(C)(C)C#N)cc2)cc1OC,,ClCCl,,CCN(CC)CC,,val
US20090137609A1,CCC(CC)(c1ccc(O)c(C)c1)c1ccc(B2OC(C)(C)C(C)(C)O2)c(C)c1.COC(=O)c1ccc(Br)o1>>CCC(CC)(c1ccc(O)c(C)c1)c1ccc(-c2ccc(C(=O)OC)o2)c(C)c1,,Cc1ccccc1,,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20160052898A1,CC(Cl)C(=O)Cl.Nc1cc(C(=O)Nc2ccc(-c3ccccc3)cc2)ccc1C(F)(F)F>>CC(Cl)C(=O)Nc1cc(C(=O)Nc2ccc(-c3ccccc3)cc2)ccc1C(F)(F)F,,Cc1ccccc1,,,,val
US20100280083A1,CC(=O)Cl.COc1cc(I)c(C(=N)NO)cc1OCc1ccccc1>>COc1cc(I)c(-c2noc(C)n2)cc1OCc1ccccc1,,c1ccncc1,,,,val
US20100029621A1,CC(C)(C)OC(=O)N1CCN(Cc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)CC1>>OC(c1ccc(CN2CCNCC2)cc1)(C(F)(F)F)C(F)(F)F,,ClCCl,,O=C(O)C(F)(F)F,,val
US07074801B1,Brc1ccc2ncc(-c3nccs3)n2c1.COC(=O)c1ccc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cc2B2OC(C)(C)C(C)(C)O2)s1>>COC(=O)c1ccc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cc2-c2ccc3ncc(-c4nccs4)n3c2)s1,,CN(C)C=O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20130345412A1,C=CCBr.Cc1ncsc1CCO>>C=CCOCCc1scnc1C,,O,,C1CCOC1,CC(C)(C)[O-].[K+],val
US05468742,CCCC[Sn](C#C[Si](C)(C)C)(CCCC)CCCC.CCOC(=O)c1cn(C2CC2)c2c(Br)c(F)c(F)cc2c1=O>>CCOC(=O)c1cn(C2CC2)c2c(C#C[Si](C)(C)C)c(F)c(F)cc2c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20130072467A1,O=C1N=C(N[C@@H]2CC(F)(F)CC[C@H]2O)CS1.O=CC1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1>>O=C1N=C(N[C@@H]2CC(F)(F)CC[C@H]2O)/C(=C/C2CCN(Cc3ccc(C(F)(F)F)cc3C(F)(F)F)CC2)S1,,CC(C)O,,C1CC[NH2+]CC1.CC(=O)[O-],,val
US20110144195A1,CC(C)(C)[Si](C)(C)Oc1ccc(-c2coc3cc(OCc4ccccc4)ccc3c2=O)c(OCc2ccccc2)c1>>CC(C)(C)[Si](C)(C)Oc1ccc(C2=Cc3ccc(OCc4ccccc4)cc3OC2)c(OCc2ccccc2)c1,,C1CCOC1,,[BH4-].[Li+],,val
US04469698,CC(C)NC(N)=O.CCOC(=O)CC(=O)OCC>>CC(C)N1C(=O)CC(=O)NC1=O,,CCO,O,Cl,[Na],val
US20070259864A1,Cc1ccc(S(=O)(=O)Cl)cc1.N#Cc1ccc(OCCN(CCO)C(N)=O)cc1>>Cc1ccc(S(=O)(=O)OCCN(CCOc2ccc(C#N)cc2)C(N)=O)cc1,,C1CCOC1,,[Li]CCCC,,val
US20100099681A1,COC(=O)c1cc(OC)ccc1Nc1c(-c2cc3nccnc3cc2C)c(C)nn1-c1ccccc1C>>COc1ccc(Nc2c(-c3cc4nccnc4cc3C)c(C)nn2-c2ccccc2C)c(C(=O)O)c1,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20160221972A1,COC(=O)c1ccc2c(c1)OC[C@H](C)NC2.COc1ccc(N=C=O)cc1>>COC(=O)c1ccc2c(c1)OC[C@H](C)N(C(=O)Nc1ccc(OC)cc1)C2,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20060276433A1,COC(=O)c1cc(C=O)cc(I)c1O>>O=Cc1cc(I)c(O)c(C(=O)O)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20020161041A1,COCOc1ccc(C2CCCC(C(N)=O)C2)c(OCOC)c1>>NC(=O)C1CCCC(c2ccc(O)cc2O)C1,,CO,,,,val
US05419893,O=C1COCC(=O)NC(COCc2ccccc2)CNCC(COCc2ccccc2)N1>>c1ccc(COCC2CNCC(COCc3ccccc3)NCCOCCN2)cc1,,C1CCOC1,,Cl,,val
US20080214598A1,O=C(CC(F)(F)F)NCc1ccc(Cl)c(CO)c1>>O=Cc1cc(CNC(=O)CC(F)(F)F)ccc1Cl,O=[Mn]=O,CC#N,,,,val
US20150299123A1,Oc1cc(F)cc(Br)c1.[CH2+]C(C)(C)[C@H]1CC[C@@H](OS(C)(=O)=O)CC1>>CC(C)(C)[C@@H]1CC[C@@H](Oc2cc(F)cc(Br)c2)CC1,,CC(C)(C)O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050054626A1,CCC[C@@H]1C[C@H](NC(=O)OC(C)(C)C)CC[C@@H]1NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)N1CCOCC1>>CCC[C@@H]1C[C@H](N)CC[C@@H]1NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)N1CCOCC1,,O=C(O)C(F)(F)F,,ClCCl,,val
US06090803,Cc1cc[nH]n1.O=C(c1ccc(F)cc1Br)N1Cc2cccnc2Nc2ccccc21>>Cc1ccn(-c2ccc(C(=O)N3Cc4cccnc4Nc4ccccc43)c(Br)c2)n1,,CCCCCC,,[H-].[Na+],,val
US20120035159A1,CC(C)(C)OC(=O)N[C@H]1CCN(S(=O)(=O)c2ccc3cnccc3c2)C1.CCCCI>>CCCCN(C(=O)OC(C)(C)C)C1CCN(S(=O)(=O)c2ccc3cnccc3c2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20160137637A1,Cc1cc(N)n[nH]1.O=C(O)c1csc(-c2ccc3c(c2)CCO3)n1>>Cc1cc(NC(=O)c2csc(-c3ccc4c(c3)CCO4)n2)n[nH]1,,c1ccncc1,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20060122230A1,CCOC(=O)c1cc(-c2ccccc2)n(-c2ccccc2)c1C>>Cc1c(C(=O)O)cc(-c2ccccc2)n1-c1ccccc1,,CCO,,[Na+].[OH-],,val
US04749815,C=CCOCc1ccc(C(C)(C)C)cc1>>CC=COCc1ccc(C(C)(C)C)cc1,[Ru],,,,,val
US20020156081A1,CN1CCNCC1.Nc1ncnc2c1c(I)nn2CCCBr>>CN1CCN(CCCn2nc(I)c3c(N)ncnc32)CC1,,CN(C)C=O,,CCN(CC)CC,,val
US04937251,BrCCCCCCBr.OCCc1ccccn1>>BrCCCCCCOCCc1ccccn1,,O,,[Na+].[OH-],,val
US20150148342A1,Cn1cc(-c2ccc3c(c2Oc2ccc(F)cc2F)NC(=O)CN3)c2cnn(COCC[Si](C)(C)C)c2c1=O>>Cn1cc(-c2ccc3ncc(=O)[nH]c3c2Oc2ccc(F)cc2F)c2cn[nH]c2c1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150232435A1,Cc1nc(N2CCN(CCCCN)CC2)cc(C(C)(C)C)n1.Cc1nnc2n1CCNC2.O=C(n1ccnc1)n1ccnc1>>Cc1nc(N2CCN(CCCCNC(=O)N3CCn4c(C)nnc4C3)CC2)cc(C(C)(C)C)n1,,CO,ClC(Cl)Cl,,,val
US20030166932A1,COc1ccc(CCCC(=O)O)cc1C>>COc1cc2c(cc1C)CCCC2=O,,CS(=O)(=O)O,,,,val
US20040152693A1,CC(=O)Cl.CC1Cc2cc3c(cc2C(c2ccc([N+](=O)[O-])cc2)=NN1C(=S)NN)OCO3>>Cc1nnc(N2N=C(c3ccc([N+](=O)[O-])cc3)c3cc4c(cc3CC2C)OCO4)s1,,ClCCl,,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US20030022881A1,CSc1ncn2cc(C3=C(C(=O)OCc4ccc([N+](=O)[O-])cc4)N4C(=O)[C@H]([C@@H](C)O)[C@H]4[C@H]3C)sc12.O=C(CBr)c1ccccc1>>CSc1c2sc(C3=C(C(=O)OCc4ccc([N+](=O)[O-])cc4)N4C(=O)[C@H]([C@@H](C)O)[C@H]4[C@H]3C)c[n+]2cn1CC(=O)c1ccccc1.[Br-],,CC(C)=O,,CCOCC,,val
US20040157804A1,COc1c2c(c(OC(c3ccccc3)c3ccccc3)c3ncn(Cc4ccccc4)c13)C(=O)N(Cc1ccc(F)cc1)C2O>>COc1c2c(c(O)c3nccnc13)C(=O)N(Cc1ccc(F)cc1)C2,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20120295884A1,COCCBr.Oc1ccc2[nH]ccc2c1>>COCCOc1ccc2[nH]ccc2c1,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090156605A1,CC(C)(C)OC(=O)c1ccc(B(O)O)cc1.COC(=O)c1c(O)c2ccc(-c3ccc(C(=O)OC(C)(C)C)cc3)cc2n(C)c1=O.COC(=O)c1c(O)c2ccc(Br)cc2n(C)c1=O>>Cn1c(=O)c(C(=O)CCC(=O)O)c(O)c2ccc(-c3ccc(C(=O)O)cc3)cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CO,[Cs+].[F-],,val
US05177087,C1CCNC1.O=C(CCCC1CCN(Cc2ccccc2)CC1)c1ccc(F)cc1>>O=C(CCCC1CCN(Cc2ccccc2)CC1)c1ccc(N2CCCC2)cc1,,C1COCCO1,,,,val
US04221725,COCCOC.COc1ccc(CCCC=O)cc1.N#CCC(=O)O>>COc1ccc(CCCC(CC(=O)O)CC(=O)O)cc1,,O,,Cl,[Na+].[OH-],val
US20130225810A1,CI.O=C(O)c1ccc(I)c([N+](=O)[O-])c1>>COC(=O)c1ccc(I)c([N+](=O)[O-])c1,,CC#N,,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20010041802A1,COc1cccc2c1-c1ccc(N)cc1C(c1ccccc1)O2.CS(=O)(=O)Cl>>COc1cccc2c1-c1ccc(NS(C)(=O)=O)cc1C(c1ccccc1)O2,,ClC(Cl)Cl,,c1ccncc1,,val
US20090270412A1,CC1c2[nH]c3ccc(Cl)cc3c2CCN1C.COc1ccc(C(C)=CBr)cc1F>>COc1ccc(C(C)=Cn2c3c(c4cc(Cl)ccc42)CCN(C)C3C)cc1F,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US06492416B1,BrBr.CSc1ccc(C2=CC(=O)C3(CCCC3)O2)cc1>>CSc1ccc(C2=C(Br)C(=O)C3(CCCC3)O2)cc1,,ClC(Cl)(Cl)Cl,,CC(=O)O,,val
US05665725,O=S(Cl)Cl.OCCCC1COc2ccc(F)cc21>>Fc1ccc2c(c1)C(CCCCl)CO2,,ClCCl,,CN(C)C=O,,val
US20070219198A1,Cc1c(S(=O)(=O)Cl)sc2ccc(Cl)cc12.O=C1CN(c2ncccc2C(F)(F)F)CCN1>>Cc1c(S(=O)(=O)N2CCN(c3ncccc3C(F)(F)F)CC2=O)sc2ccc(Cl)cc12,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20110183953A1,C=CS(C)(=O)=O.CC(C)Oc1ccc(-c2nnc(-c3cccc4c3CC[C@@H]4N)s2)cc1C#N>>CC(C)Oc1ccc(-c2nnc(-c3cccc4c3CC[C@@H]4NCCS(C)(=O)=O)s2)cc1C#N,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,Cl,val
US20030032623A1,CCCCCNCCC12CC3CC(CC(C3)C1)C2.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O.OCCCc1ccncc1>>CCCCCN(CCC12CC3CC(CC(C3)C1)C2)C(=O)OCCCc1ccncc1,,CC#N,ClCCl,CCN(CC)CC,Cl,val
US20120122860A1,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(C#N)cc23)c1F.C[Si](C)(C)N=[N+]=[N-]>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4nn[nH]n4)cc23)c1F,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US20010025045A1,BrBr.COc1cc(C(C)C)ccc1C(=O)O>>COc1cc(C(C)C)c(Br)cc1C(=O)O,,ClC(Cl)Cl,,,,val
US20140336106A1,COC(=O)[C@@H]1CC(=O)N(Cc2ccc(OC)cc2OC)C1>>COc1ccc(CN2C[C@H](C(=O)O)CC2=O)c(OC)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20060211727A1,COc1cc(Br)c(CCC(=O)Nc2ccccc2Cl)c(Br)c1>>COc1cc(Br)c2c(c1)N(c1ccccc1Cl)C(=O)CC2,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120214788A1,COC(=O)C1CNCC(c2cccc(C(F)(F)F)c2)C1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>COC(=O)C1CC(c2cccc(C(F)(F)F)c2)CN(C(=O)Oc2ccc([N+](=O)[O-])cc2)C1,,ClCCl,,CCN(CC)CC,,val
US04064257,C#CCCCCNC(=O)c1cnc(SCC)s1.OO>>C#CCCCCNC(=O)c1cnc(S(=O)CC)s1,,CC(=O)O,,,,val
US20090306129A1,CCn1ncc2c(NC3CC3)c(C=O)cnc21.NO>>CCn1ncc2c(NC3CC3)c(C=NO)cnc21,,CCO,,Cl,CC(=O)[O-].[Na+],val
US05886015,CNN.O=C(C=Cc1cccc(O)c1)c1ccccc1>>CN1N=C(c2ccccc2)CC1c1cccc(O)c1,,CCO,,,,val
US20070105904A1,C#Cc1ccc(N)nc1N.ON=C(Cl)Cc1ccc(CNc2ccccc2)cc1>>Nc1ccc(-c2cc(Cc3ccc(CNc4ccccc4)cc3)no2)c(N)n1,,C1CCOC1,,CCN(CC)CC,,val
US04814346,BrCC1CO1.COc1ccc(-c2coc3c(C)c(O)ccc3c2=O)cc1OC>>COc1ccc(-c2coc3c(C)c(OCC4CO4)ccc3c2=O)cc1OC,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150336920A1,CN.Cc1cc2c(cc1C)C1(Cl)C(=O)c3ccccc3C1(O)O2>>CNC12C(=O)c3ccccc3C1(O)Oc1cc(C)c(C)cc12,,C1CCOC1,,,,val
US04281141,ClCc1c[nH]cn1.N#CC(c1ccccc1)c1ccccn1>>N#CC(Cc1c[nH]cn1)(c1ccccc1)c1ccccn1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20090253687A1,CC(O)c1cc(-c2ccc3c(c2)NC(=O)CO3)n(-c2ccc(F)cc2)n1>>CCc1cc(-c2ccc3c(c2)NC(=O)CO3)n(-c2ccc(F)cc2)n1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20020035115A1,Cc1c(Cl)nc(Cl)c(=O)n1CC(=O)OCc1ccccc1.NCCc1ccccc1>>Cc1c(Cl)nc(NCCc2ccccc2)c(=O)n1CC(=O)OCc1ccccc1,,CCOC(C)=O,,,,val
US04316043,C=CC1(CCC(C)=O)Cc2cc(OCC(=O)OC)c(Cl)c(Cl)c2C1=O>>C=CC12CCC(=O)C=C1c1c(cc(OCC(=O)O)c(Cl)c1Cl)C2,,CO,O,[Na+].[OH-],,val
US20090192156A1,COC[C@@H](C)O.Oc1ccncc1>>COC[C@H](C)Oc1ccncc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070078155A1,Fc1ccc(Br)nc1.Nc1ncc(-c2cncc(F)c2)c2cccnc12>>Fc1ccc(Nc2ncc(-c3cncc(F)c3)c3cccnc23)nc1,,C1COCCO1,,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20040214832A1,BrCc1ccccc1.CC(C)(C)OC(=O)N1CC(=O)N(c2ccc(O)cc2)[C@@H](CO)C1>>CC(C)(C)OC(=O)N1CC(=O)N(c2ccc(OCc3ccccc3)cc2)[C@@H](CO)C1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090131458A1,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=CC1=CCCOC1>>CCOC(=O)/C=C/C1=CCCOC1,,ClCCl,,,,val
US20090275588A1,CCN.Cn1ccc(C=O)n1>>CCNCc1ccn(C)n1,,C1CCOC1,,,,val
US20040171638A1,CC(C)(C)OC(=O)n1c(CNC2CCCc3cccnc32)nc2ccccc21.O=Cc1ccc(-c2ccccn2)cc1>>c1ccc(-c2ccc(CN(Cc3nc4ccccc4[nH]3)C3CCCc4cccnc43)cc2)nc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20150344425A1,Cc1cc([N+](=O)[O-])cc(Cl)c1N.N#C[Cu]>>Cc1cc([N+](=O)[O-])cc(Cl)c1C#N,,CC#N,,CC(C)(C)ON=O,,val
US20070259855A1,CC(C)c1cccc(Br)c1.N#C[Cu]C#N>>CC(C)c1cccc(C#N)c1,,Cc1ccccc1,c1ccncc1,N,O,val
US20100075952A1,CCOC(=O)c1c(CCCNCCN2CCOCC2)[nH]c(C(=O)OC(C)(C)C)c1C>>Cc1c(C(=O)OC(C)(C)C)[nH]c2c1C(=O)N(CCN1CCOCC1)CCC2,,Cc1ccccc1,,C[Al](C)C,,val
US20060293319A1,Clc1cccc(CBr)c1.O=C1Nc2cc(Cl)ccc2C1c1cccnc1>>O=C1Nc2cc(Cl)ccc2C1(Cc1cccc(Cl)c1)c1cccnc1,,CC(C)=O,CCOC(C)=O,[I-].[K+],,val
US20090136424A1,C=C(C)[C@H]1Cc2c(ccc3c2O[C@@H]2COc4cc(OC)c(OC)cc4[C@@H]2C3=O)O1>>C=C(C)[C@H]1Cc2c(ccc(C(=O)C3CCOc4cc(OC)c(OC)cc43)c2O)O1,,CO,,O,[BH4-].[Na+],val
US20040106622A1,CCOC(=O)C1CCNCC1.Cc1cc(Cl)nc(N)n1>>CCOC(=O)C1CCN(c2cc(C)nc(N)n2)CC1,,CCO,,CCN(CC)CC,,val
US04053471,CCN(C)CCCOc1ccccc1C1SCC(=O)N1CCc1ccc([N+](=O)[O-])cc1>>CCN(C)CCCOc1ccccc1C1SCC(=O)N1CCc1ccc(N)cc1,[Pd],CCO,,[H][H],,val
US20030069419A1,FC(F)(F)c1ccc(/C=C/c2nc(CCl)co2)cc1.Oc1ccc(CCCCn2ccnn2)cc1>>FC(F)(F)c1ccc(/C=C/c2nc(COc3ccc(CCCCn4ccnn4)cc3)co2)cc1,,CN(C)C=O,CO,O,O=C([O-])[O-].[K+].[K+],val
US20150152047A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCC[C@H]1CCCN(C(=O)OCc2ccccc2)C1>>CC(C)(C)OC(=O)NCCC[C@H]1CCCN(C(=O)OCc2ccccc2)C1,,CCO,O,O=C([O-])O.[Na+],,val
US20010053851A1,Nc1nccs1.O=C(O)C(CC1CCCC1)c1ccc(C#Cc2cncnc2)cc1>>O=C(Nc1nccs1)C(CC1CCCC1)c1ccc(C#Cc2cncnc2)cc1,,ClCCl,O,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US05147893,CC(C)(C)c1cc(S[C@@H]2CCCC[C@H]2SCC(=O)O)cc(C(C)(C)C)c1O.CNCCc1ccccn1>>CN(CCc1ccccn1)C(=O)CS[C@@H]1CCCC[C@H]1Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,,C1CCOC1,c1ccccc1,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20050267148A1,COC(OC)N(C)C.Cc1cccc([N+](=O)[O-])c1C>>Cc1cccc2[nH]ccc12,,CN(C)C=O,,C1CCNC1,,val
US20150057265A1,COc1ccncc1Cl.O=C(OO)c1cccc(Cl)c1>>COc1cc[n+]([O-])cc1Cl,,ClCCl,,,,val
US20140296204A1,O=C1NC(=O)c2ccccc21.OCc1ccccc1-c1nccs1>>O=C1c2ccccc2C(=O)N1Cc1ccccc1-c1nccs1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05220018,CC(C)S(=O)(=O)Cl.NC(=O)c1cccc([N+](=O)[O-])c1>>CC(C)S(=O)(=O)NC(=O)c1cccc([N+](=O)[O-])c1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US04835165,Cc1cnc(N2CCC(c3ccc([N+](=O)[O-])cc3)CC2)n1C>>Cc1cnc(N2CCC(c3ccc(N)cc3)CC2)n1C,,CO,,,,val
US20100004301A1,CC(C)Oc1ccc(-c2ccc3oc(-c4cc(N)ccc4Cl)nc3c2)cc1.O=S(=O)(Cl)c1cc(Cl)ccc1Cl>>CC(C)Oc1ccc(-c2ccc3oc(-c4cc(NS(=O)(=O)c5cc(Cl)ccc5Cl)ccc4Cl)nc3c2)cc1,,O,c1ccncc1,,,val
US20020013328A1,CCOC(CC)=C(C#N)C(N)=O.NNc1c(Cl)cc(Cl)cc1Cl>>CCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(N)c1C(N)=O,,CO,,O,,val
US20100063115A1,CC(C)(C)OC(=O)CNc1nnc(-c2ccc(F)c(C#N)c2)o1>>N#Cc1cc(-c2nnc(NCC(=O)O)o2)ccc1F,,C1COCCO1,Cl,,,val
US20100160369A1,O=C1NC(COc2cc(Cl)c(-c3nnc(-c4cn5cc(C(F)(F)F)cc(Cl)c5n4)o3)cc2Cl)CO1>>NC(CO)COc1cc(Cl)c(-c2nnc(-c3cn4cc(C(F)(F)F)cc(Cl)c4n3)o2)cc1Cl,,CCO,O,,,val
US20110178132A1,N#Cc1cc(-c2cc(C(F)(F)F)ccc2F)ccn1.NO>>NC(=NO)c1cc(-c2cc(C(F)(F)F)ccc2F)ccn1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20120059030A1,CI.COc1cc(-c2nnc3n2CCCC3(CO)Cc2ccc(F)c(F)c2)ccc1-c1cnc(C)o1>>COCC1(Cc2ccc(F)c(F)c2)CCCn2c(-c3ccc(-c4cnc(C)o4)c(OC)c3)nnc21,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US05166347,CO.N#Cc1ccc(C#N)cc1>>COC(=N)c1ccc(C#N)cc1,,CO,,CC(=O)O,C[O-].[Na+],val
US05998433,C=CCNCc1ccoc1.OCCBr>>C=CCN(CCO)Cc1ccoc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100152163A1,CC(=CBr)c1ccccc1F.CN1CCc2[nH]c3ccc(Cl)cc3c2CC1>>C/C(=C/n1c2c(c3cc(Cl)ccc31)CCN(C)CC2)c1ccccc1F,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20100261683A1,CC(C)C(C#N)C=O.NN>>CC(C)c1cn[nH]c1N,,CCO,,CC(=O)O,O,val
US20140235863A1,CC(=O)c1ccc(C=NNC(N)=S)c(N)c1.O=C(CBr)c1cccc(Cl)c1>>CC(=O)c1ccc(C=NNc2nc(-c3cccc(Cl)c3)cs2)c(N)c1,,C1CCOC1,,,,val
US20150031668A1,CCOC(C)=O.COC(=O)c1ccc(C#N)cc1CBr.N>>O=C(O)c1ccc2c(c1)CNC2=O,,CO,,,,val
US20090275574A1,CC(C)I.OCC1CCC2(CC1)OCCO2>>CC(C)OCC1CCC2(CC1)OCCO2,O=[Ag-],CCOCC,,,,val
US20100029657A1,O=Cc1ccc(F)c2[nH]ncc12.O=S(=O)(Cl)c1ccccc1>>O=Cc1ccc(F)c2c1cnn2S(=O)(=O)c1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US05599833,CCCCS(=O)(=O)c1ccc(-c2sc3cc(O)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1.Cl>>CCCCS(=O)(=O)c1ccc(-c2sc3cc(O)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1.Cl,,CCOC(C)=O,,CCOCC,,val
US20090275590A1,C=O.Cn1c2c(c3cc(-n4ccc(OCc5ccccc5)cc4=O)ccc31)CNCC2>>CN1CCc2c(c3cc(-n4ccc(OCc5ccccc5)cc4=O)ccc3n2C)C1,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20060211709A1,CC(C)(C)OC(=O)N1CCC[C@H](N)C1.COC(=O)c1nc(-c2cccc(CNC3c4ccccc4CC3O)c2)cnc1N>>Nc1ncc(-c2cccc(CN[C@@H]3c4ccccc4C[C@@H]3O)c2)nc1C(=O)N[C@H]1CCCNC1,,O,,,,val
US20080027093A1,CN(C)C(=O)[C@@H](c1ccc(O)cc1)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CC[C@H](F)C1>>CN(C)C(=O)[C@@H](C1CCC(O)CC1)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CC[C@H](F)C1,[Rh],CO,,[H][H],,val
US20110275611A1,CC1(C)OB(c2ccc(C#N)c(F)c2)OC1(C)C.Nc1nc(Cl)cc(N2CCOC(c3nc4cc(Cl)ccc4[nH]3)C2)n1>>N#Cc1ccc(-c2cc(N3CCOC(c4nc5cc(Cl)ccc5[nH]4)C3)nc(N)n2)cc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20120277224A1,CI.O=C(O)c1ccc2c(c1)OCO2>>Cc1c(C(=O)O)ccc2c1OCO2,,C1CCOC1,,[Li]CCCC,,val
US20090176794A1,Nn1ccc2cc(Cl)ccc21.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nn1ccc2cc(Cl)ccc21,,ClCCl,,,,val
US20030212100A1,COC(=O)CC(=O)OC.O=Cc1ccc(O)cc1>>COC(=O)C(=Cc1ccc(O)cc1)C(=O)OC,,c1ccccc1,,C1CCNCC1,,val
US20030158198A1,Cc1cc2c(N)cccc2cn1.O=C=NCc1ccc(C(F)(F)F)c(F)c1>>Cc1cc2c(NC(=O)NCc3ccc(C(F)(F)F)c(F)c3)cccc2cn1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US20060111412A1,CCOC(=O)c1cc(OCc2ccc(OC)cc2)n(CC(=O)N[C@H]2CCCC[C@@H]2OCc2ccccc2)n1>>CCOC(=O)c1cc(O)n(CC(=O)N[C@H]2CCCC[C@@H]2OCc2ccccc2)n1,,O,,O=C(O)C(F)(F)F,,val
US04096336,CC(=O)CC(C)=O.ClCCCc1ccccc1CCl>>CC(=O)CCc1ccccc1CCCCl,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US04820834,CCOC(=O)CN1C(=O)C(N)N=C(c2ccccc2)c2ccccc21.O=C=Nc1ccc(Cl)cc1>>CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21,,C1CCOC1,,,,val
US20070191372A1,NCCN(CCN)c1n[n+]([O-])c2ccccc2[n+]1[O-].O=C(c1cccc2ccc(-c3ccncc3)nc12)n1ccnc1>>O=C(NCCNCCNc1n[n+]([O-])c2ccccc2[n+]1[O-])c1cccc2ccc(-c3ccncc3)nc12,,CN(C)C=O,,,,val
US20090264650A1,FC(F)(F)CBr.O=C1C(Cc2ccc(O)cc2Cl)CCN1C1CCCCC1>>O=C1C(Cc2ccc(OCC(F)(F)F)cc2Cl)CCN1C1CCCCC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090082434A1,Cc1ccc(S(=O)(=O)OCC2Cc3cccc(Br)c3O2)cc1.OB(O)/C=C/c1ccccc1>>Cc1ccc(S(=O)(=O)OCC2Cc3cccc(/C=C/c4ccccc4)c3O2)cc1,Cc1ccccc1[P](c1ccccc1C)(c1ccccc1C)[Pd](Cl)(Cl)[P](c1ccccc1C)(c1ccccc1C)c1ccccc1C,,,O=C([O-])[O-].[K+].[K+],,val
US04439433,CCOC(=O)C(=NOCCBr)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1.NC(c1ccccc1)(c1ccccc1)c1ccccc1>>O=C(O)C(=NOCCNC(c1ccccc1)(c1ccccc1)c1ccccc1)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,O,,CS(C)=O,,val
US20100009970A1,COC(=O)c1ccc2c(c1)[C@@H](N(C)C(=O)OC(C)(C)C)CC[C@H]2c1ccc(Cl)c(Cl)c1>>CN(C(=O)OC(C)(C)C)[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(C(=O)O)cc21,,CO,O,Cl,[Li+].[OH-],val
US03933906,CC(=O)Nc1ccc(Nc2c(N)cc(C(=O)O)cc2S(N)(=O)=O)cc1.ClCc1ccccc1>>CC(=O)Nc1ccc(Nc2c(NCc3ccccc3)cc(C(=O)O)cc2S(N)(=O)=O)cc1,,O,,[Na+].[OH-],,val
US20040167119A1,COC(=O)c1ccc(C=C[N+](=O)[O-])cc1>>COC(=O)c1ccc(CCN)cc1,[Pd],CC(=O)O,CCO,[H][H],,val
US20150291554A1,N#CBr.NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn(C2CCCNC2)c1N>>N#CN1CCCC(n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US09248117B2,CC(C)(C)OCl.CC1(C)NC(C)(C)N(CC(O)CO)C1=O>>CC1(C)C(=O)N(CC(O)CO)C(C)(C)N1Cl,,CO,,,,val
US20030100555A1,Cc1cc(C)c(/C=C2\C(=O)N(C(=O)Cl)c3ccccc32)[nH]1.OCC(O)CO>>Cc1cc(C)c(/C=C2\C(=O)N(C(=O)OCC(O)CO)c3ccccc32)[nH]1,,C1CCOC1,c1ccncc1,,,val
US20050148623A1,CC(C)(C)OC(=O)[C@@H](N1CCN(Cc2ccccc2)C1=O)C(C)(C)C>>CC(C)(C)[C@@H](C(=O)O)N1CCN(Cc2ccccc2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030055246A1,CCOC(=O)CN1CCN(C(=O)OC(C)(C)C)CC1.CNOC>>CON(C)C(=O)CN1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,C[Al](C)C,Cl,val
US05929085,CN1CC2CCCN2Cc2cc([N+](=O)[O-])ccc21.Cl>>CN1CC2CCCN2Cc2cc(N)ccc21.Cl,,CO,,,,val
US05650428,CCOC(=O)c1cccc(N)c1.O=C(O)[C@H](Cc1ccccc1)NS(=O)(=O)c1ccc(Br)cc1>>CCOC(=O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NS(=O)(=O)c2ccc(Br)cc2)c1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060189825A1,NNC(=O)c1ccc(O)cc1.O=Cc1cccc(C(F)(F)F)c1Cl>>O=C(NN=Cc1cccc(C(F)(F)F)c1Cl)c1ccc(O)cc1,CC(=O)O,CCO,,,,val
US20110306636A1,N#Cc1ccnc(CO)c1.NO>>NC(=NO)c1ccnc(CO)c1,,CCO,,,,val
US20040142850A1,CCOC(=O)Cl.Nc1ccc(Br)cc1C(F)(F)F>>CCOC(=O)Nc1ccc(Br)cc1C(F)(F)F,,c1ccncc1,,Cl,O,val
US06350749B1,Cc1ccc(S(=O)(=O)Cl)cc1.O=C1CC(c2ccccc2)Cc2[nH]ccc21>>Cc1ccc(S(=O)(=O)n2ccc3c2CC(c2ccccc2)CC3=O)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05194429,C1=COCCC1.CCCCCCC[C@H](O)/C=C/[C@H]1[C@H](OC(=O)c2ccc(-c3ccccc3)cc2)C[C@@H]2OC(=O)C[C@@H]21>>CCCCCCC[C@@H](/C=C/[C@H]1[C@H](OC(=O)c2ccc(-c3ccccc3)cc2)C[C@@H]2OC(=O)C[C@@H]21)OC1CCCCO1,,ClCCl,,,,val
US06525067B1,CCC(N)c1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C.CN=C=O>>CCC(NC(=O)NC)c1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C,,CC(Cl)Cl,,,,val
US20050222118A1,C[C@H](CCI)NC(=O)OC(C)(C)C.Clc1ccc(OC2CNC2)cc1>>C[C@H](CCN1CC(Oc2ccc(Cl)cc2)C1)NC(=O)OC(C)(C)C,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20080125452A1,CN=C=S.COC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cc(C)cc(C)c2)N1>>Cc1cc(C)cc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(C)C(=S)N32)c1,,CC(C)=O,,,,val
US20060281746A1,CC(=O)NC1(c2ccccc2)CCNCC1.CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1/C=C/C=O>>CC(=O)NC1(c2ccccc2)CCN(C/C=C/[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccc(F)cc2)c2ccc(Cl)c(Cl)c2)CC1,,CCO,,[BH3-]C#N.[Na+],,val
US20050026964A1,CCOC(=O)c1cnc(Cl)cc1Cl.Nc1ccc(Br)cc1F>>CCOC(=O)c1cnc(Cl)cc1Nc1ccc(Br)cc1F,,CCO,,Cl,,val
US06333330B1,CCOc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1C(=O)O.ClCCl.O=C(Cl)C(=O)Cl>>CCOc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1C(=O)Cl.Cl,CN(C)C=O,ClCCl,,,,val
US20140187545A1,FC(F)(F)c1nn2c(Cl)cc(Cl)nc2c1Cc1cccc(Cl)c1Cl.O>>Oc1cc(Cl)nc2c(Cc3cccc(Cl)c3Cl)c(C(F)(F)F)nn12,,C1CCOC1,O,[Na+].[OH-],,val
US08669398B2,CC(=O)OC1CC(C)(C)N(O)C(C)(C)C1.CC(C)c1cccc(C(C)C)c1N=C=Nc1c(C(C)C)cccc1C(C)C>>CC(=O)OC1CC(C)(C)N(OC(=Nc2c(C(C)C)cccc2C(C)C)Nc2c(C(C)C)cccc2C(C)C)C(C)(C)C1,,C1CCOC1,,,,val
US20080318956A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.COCOc1ccc(I)cc1C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(-c2ccccn2)ccc1O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O,,val
US20120208800A1,CCOC(=O)C[N+](=O)[O-].Nc1ccc(Br)cc1C=O>>O=c1[nH]c2ccc(Br)cc2cc1[N+](=O)[O-],,CCO,,C1CCNCC1,,val
US20150291595A1,Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(Br)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12.Cn1nc(C(F)(F)F)cc1B1OC(C)(C)C(C)(C)O1>>Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cc(C(F)(F)F)nn3C)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20110201643A1,CC(=O)O.O=C(NOC1CCCCO1)c1ccc2c(c1)CCNC2>>CC(=O)N1CCc2cc(C(=O)NOC3CCCCO3)ccc2C1,,CCN(CC)CC,CN(C)C=O,ClCCCl,On1nnc2ccccc21,val
US20140296208A1,CC(C)(C)c1cc(NC(=O)Oc2ccccc2)cc(NS(C)(=O)=O)c1.CC(C)[Si](C#Cc1cc(Nc2cc(Oc3ccc(N)c4ccccc34)ccn2)cc(C(=O)NCCN2CCOCC2)c1)(C(C)C)C(C)C>>CC(C)[Si](C#Cc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(NS(C)(=O)=O)cc(C(C)(C)C)c4)c4ccccc34)ccn2)cc(C(=O)NCCN2CCOCC2)c1)(C(C)C)C(C)C,,CC(=O)OC(C)C,,CCN(CC)CC,,val
US04562258,Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1>>Cc1ccc(/C(=C\CN2CCCC2)c2cccc(CCC(=O)O)n2)cc1,[Ni],,,,,val
US20110039843A1,CC(C)(C)c1ccc(O)c(N)c1.O=C(Cl)c1cc(Cl)ncc1C(F)(F)F>>CC(C)(C)c1ccc(O)c(NC(=O)c2cc(Cl)ncc2C(F)(F)F)c1,,O,,CCN(CC)CC,CN(C)C=O,val
US20060217387A1,CC(C)(C)OC(=O)N1CCNCC1.O=S(=O)(Cl)c1ccc(Br)s1>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(Br)s2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20060111375A1,COc1cc2nccc(Oc3ccc(C)nc3I)c2cc1OC.OB(O)c1cccc(Cl)c1>>COc1cc2nccc(Oc3ccc(C)nc3-c3cccc(Cl)c3)c2cc1OC,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20090137595A1,COC(=O)c1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1>>O=C(O)c1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20060281763A1,CCOC=O.COC(=O)CC1CCCC1>>COC(=O)C(C=O)C1CCCC1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20030176418A1,CCCCC1CC2CCC(C1)N2.C[C@H](CI)CN1C(=O)COc2cc(F)ccc21>>CCCCC1CC2CCC(C1)N2C[C@@H](C)CN1C(=O)COc2cc(F)ccc21,,CC#N,,,,val
US05998433,CN(C)Cc1cc2c(o1)CCN(C(=O)c1ccc(C(=O)c3ccc(Cl)cc3)cc1)C2.Cl>>CN(C)Cc1cc2c(o1)CCN(C(=O)c1ccc(C(=O)c3ccc(Cl)cc3)cc1)C2.Cl,,CCOC(C)=O,CO,,,val
US20070155721A1,CCOC(=O)c1cc2c(O)cccc2[nH]1.OCC1CCC1>>O=C(O)c1cc2c(OCC3CCC3)cccc2[nH]1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130123268A1,Brc1ccccn1.CC(C)(C)OC(=O)N1C2CCC1CC(=O)C2>>CC(C)(C)OC(=O)N1C2CCC1CC(O)(c1ccccn1)C2,,C1CCOC1,CCOC(C)=O,[Li]CCCC,O=C([O-])O.[Na+],val
US04577018,CC(=O)C1CCOC1=O.N=C(N)NN>>Cc1nc(N)n(N)c(=O)c1CCO,,CCCCO,,O=C(O)O,,val
US20140309208A1,Nc1cccc([N+](=O)[O-])c1N>>Nc1cccc(N)c1N,[Pd],CO,,,,val
US20160221945A1,CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)O.NCc1cc(-c2cnc(C(F)(F)F)nc2)ncc1Cl>>CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cc(-c2cnc(C(F)(F)F)nc2)ncc1Cl,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04062965,CCCCCCCCCCCCBr.CCCCCCCCCCCCn1ccnc1CC>>CCCCCCCCCCCCN1C=CN(CCCCCCCCCCCC)C1CC.[Br-],,CCO,,,,val
US20080194556A1,C=O.CCOc1cc(OC[C@H]2CCCN2)c2c(Nc3cnn(CC(=O)Nc4cccc(F)c4F)c3)ncnc2c1>>CCOc1cc(OC[C@H]2CCCN2C)c2c(Nc3cnn(CC(=O)Nc4cccc(F)c4F)c3)ncnc2c1,,O,O=CO,,,val
US08637532B2,CC(C)(C)OC(=O)NC(CCO)c1cccc(NC(=O)c2cc(C3CC3)n[nH]2)c1>>NC(CCO)c1cccc(NC(=O)c2cc(C3CC3)n[nH]2)c1,,C1COCCO1,,Cl,,val
US20050187220A1,CN(C)C1(c2ccccc2)CCC(O)CC1.Fc1cccc(CCl)c1>>CN(C)C1(c2ccccc2)CCC(OCc2cccc(F)c2)CC1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20140038975A1,CCOC(=O)[C@@](C)(CCn1cc(-c2cnc3ccccc3n2)cn1)S(C)(=O)=O>>C[C@@](CCn1cc(-c2cnc3ccccc3n2)cn1)(C(=O)O)S(C)(=O)=O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20080207666A1,CC1(C)C[C@H](O)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1.O=C(Cl)c1ccccc1>>CC1(C)C[C@H](OC(=O)c2ccccc2)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20120046306A1,CCOC(=O)CC(=O)OC(C)(C)C.O=[N+]([O-])c1cc(Cl)sc1Cl>>CCOC(=O)Cc1sc(Cl)cc1[N+](=O)[O-],,CS(C)=O,O,Cl,[H-].[Na+],val
US05554746,O=C(Nc1ccn(C2C(=O)N(OCc3ccccc3)C2COCc2ccccc2)c(=O)n1)c1ccccc1>>O=C(Nc1ccn(C2C(=O)N(O)C2CO)c(=O)n1)c1ccccc1,[Ni],CO,,[H][H],,val
US04045556,NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)c1[nH]c(=O)[nH]c(=O)c1Cl>>Cl.NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)c1cc(=O)[nH]c(=O)[nH]1,[Pd],CC(=O)O,,[H][H],,val
US20070197537A1,BrCCBr.O=c1[nH]c(Nc2ccccc2)ncc1Br>>O=c1c(Br)cnc2n1CCN2c1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120289526A1,COc1ccc(C)c(Oc2ccc(NC(=O)[C@@H](C)N(C(=O)[O-])C(C)(C)C)cc2)c1>>COc1ccc(C)c(Oc2ccc(NC(=O)[C@@H](C)N)cc2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030166658A1,CC(=O)c1cc2ccccc2cn1.Cn1c(NN)nc2ccccc21>>CC(=NNc1nc2ccccc2n1C)c1cc2ccccc2cn1,CC(=O)O,CO,,,,val
US20130252944A1,CI.COc1ccc(Cn2cc3c(n2)CC(O)CCC3=O)cc1>>COc1ccc(Cn2cc3c(n2)CC(OC)CCC3=O)cc1,,C1CCOC1,,[H-].[Na+],,val
US20150057265A1,CN1CCN(Cc2cnc3c(C(=O)Nc4cnccc4N4C[C@H](C(F)(F)F)C[C@H](NC(=O)OC(C)(C)C)C4)c(NC(=O)OC(C)(C)C)oc3c2)CC1>>CN1CCN(Cc2cnc3c(C(=O)Nc4cnccc4N4C[C@H](C(F)(F)F)C[C@H](N)C4)c(N)oc3c2)CC1,,CO,,C1COCCO1,Cl,val
US20130310395A1,O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(Cl)c(Br)c1.O[C@H]1CCNC1>>O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@H](O)C2)c(Br)c1,,CC(C)O,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20060128685A1,CC(=O)c1cccnn1.COC(=O)C(=O)OC>>COC(=O)C(=O)CC(=O)c1cccnn1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100234395A1,CCOC(=O)CCNO.COc1ccc(-c2nc(C3CCN(C(=O)Cl)CC3)oc2-c2ccc(OC)cc2)cc1>>CCOC(=O)CCN(O)C(=O)N1CCC(c2nc(-c3ccc(OC)cc3)c(-c3ccc(OC)cc3)o2)CC1,,C1CCOC1,,CCN(CC)CC,O,val
US20140107106A1,CCN=C=NCCCN(C)C.CCOc1c(CCN)cccc1C(C)C.CN(C)C=O.On1nnc2ccccc21>>CCOc1c(CN(C)C(=O)/C=C/c2cnc3c(c2)CCC(=O)N3)cccc1C(C)C,,O,,CCN(C(C)C)C(C)C,Cl,val
US20070232612A1,CN1C[C@H]2[C@H](CCN2c2ccc(-c3ccc(-n4ncccc4=O)cc3)cc2)C1.O.O=C(O)C(O)C(O)C(=O)O>>CN1C[C@H]2[C@H](CCN2c2ccc(-c3ccc(-n4ncccc4=O)cc3)cc2)C1.O.O=C(O)[C@H](O)[C@@H](O)C(=O)O,,O,,ClCCl,,val
US20150291549A1,Cc1c(COc2ccc(C=O)c(O)c2Cl)cccc1-c1ccccc1.N#Cc1cccc(CBr)c1>>Cc1c(COc2ccc(C=O)c(OCc3cccc(C#N)c3)c2Cl)cccc1-c1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06548676B1,OCC1SC(SCc2ccccc2)=NC1O>>OCc1cnc(SCc2ccccc2)s1,,CCO,,Cl,,val
US20100016295A1,COC(=O)[C@@H](NS(=O)(=O)c1ccc(-c2ccc(N)cc2)cc1)C(C)C.O=C(Cl)c1ccc(F)c(F)c1>>CC(C)[C@H](NS(=O)(=O)c1ccc(-c2ccc(NC(=O)c3ccc(F)c(F)c3)cc2)cc1)C(=O)O,,ClCCl,,c1ccncc1,,val
US20110098297A1,CCOC(=O)CC1CN=C(c2cc3cc(Oc4ccc(S(C)(=O)=O)nc4)cc(OCC)c3[nH]2)S1>>CCOc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C3=NCC(CCO)S3)[nH]c12,,C1CCOC1,,CO,[BH4-].[Li+],val
US20110263578A1,CC(=O)Cl.Fc1cccnc1[C@@H]1CC[C@@H](c2nnc3n2-c2ccc(Cl)cc2CNC3)CC1>>CC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2[C@@H]2CC[C@@H](c3ncccc3F)CC2)C1,,ClCCl,,CCN(CC)CC,,val
US20160151483A1,COC(C)(C)OC.OCC(O)CO>>CC1(C)OCC(CO)O1,,CN(C)C=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120165347A1,CC(=O)c1cc(Br)ccc1O.CC1(C)CC(C=O)CCO1>>CC1(C)CC(C2CC(=O)c3cc(Br)ccc3O2)CCO1,,CO,,C1CCNC1,,val
US05187190,CC1(COc2ccc(O)cc2)OCCO1.O=C1OC(COc2ccccc2)CN1CCO>>CC1(COc2ccc(OCCN3CC(COc4ccccc4)OC3=O)cc2)OCCO1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030078276A1,BrCc1ccccc1.COC(=O)c1ccc2c(c1)S(=O)(=O)NC(=O)N2C>>COC(=O)c1ccc2c(c1)S(=O)(=O)N(Cc1ccccc1)C(=O)N2C,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20110065681A1,Cc1ccc(-c2cc(C(=O)O)cc(C(=O)N3CCCC3)c2)cc1.NCc1ccc2cccnc2c1>>Cc1ccc(-c2cc(C(=O)NCc3ccc4cccnc4c3)cc(C(=O)N3CCCC3)c2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100120785A1,CC(C)(C)OC(=O)N1CCN(c2nccnc2-c2ccc(CO)cc2)CC1>>OCc1ccc(-c2nccnc2N2CCNCC2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060229326A1,CCCCOc1ncc(C(=O)O)cc1-c1cc(C(F)(F)F)ccc1F.N[C@@H]1CCCC[C@H]1O>>CCCCOc1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1cc(C(F)(F)F)ccc1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20110224204A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc(F)cc1-c1ccncc1>>O=S(=O)(Oc1ccc(F)cc1-c1ccncc1)C(F)(F)F,,c1ccncc1,,,,val
US20100144722A1,COC(=O)C1(c2ccc(N)cc2)CCC1.Cc1noc(C)c1-c1cc(N2CCC(F)(F)CC2)nc(Cl)n1>>COC(=O)C1(c2ccc(Nc3nc(-c4c(C)noc4C)cc(N4CCC(F)(F)CC4)n3)cc2)CCC1,,CCCCO,,,,val
US20090012279A1,CN(C)c1cccc2c(S(=O)(=O)NCCC(=O)Cl)cccc12.[N-]=[N+]=NS(=O)(=O)c1ccc(N)cc1>>CN(C)c1cccc2c(S(=O)(=O)NCCC(=O)c3ccccc3S(=O)(=O)N=[N+]=[N-])cccc12,,CN(C)C=O,,CCN(CC)CC,,val
US20090318408A1,COc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C>>COc1cc(C(=O)NC2CCNCC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090036452A1,CN1CCNCC1.COC(=O)c1ccc(Cl)nc1>>COC(=O)c1ccc(N2CCN(C)CC2)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20050043388A1,NNS(=O)(=O)c1ccc(Cl)c([N+](=O)[O-])c1.O=C1Nc2ccc(I)cc2C1=O>>O=C1Nc2ccc(I)cc2C1=NNS(=O)(=O)c1ccc(Cl)c([N+](=O)[O-])c1,,CC(=O)O,,,,val
US04599361,CCOC(=O)C=C(CC(C)C)C(=O)OCc1ccccc1>>CCOC(=O)CC(CC(C)C)C(=O)O,[Pd],CCO,,,,val
US05610303,O=C(C=CC1CCN(Cc2ccccc2)CC1)c1ccc([N+](=O)[O-])cc1>>Nc1ccc(C(=O)/C=C/C2CCN(Cc3ccccc3)CC2)cc1,,CC(=O)O,,Cl,,val
US20040192698A1,N#CCCN.Nc1ccccc1S>>NCCc1nc2ccccc2s1,,CCO,,,,val
US05637723,COC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c1ccccc1.COC(OC)OC>>COC(=O)[C@@H]1OC(OC)N(C(=O)OC(C)(C)C)[C@H]1c1ccccc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20140051672A1,CC1(C)CC(Oc2ccc(-c3ccc(O)cc3F)nn2)CC(C)(C)N1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC1(C)CC(Oc2ccc(-c3ccc(OS(=O)(=O)C(F)(F)F)cc3F)nn2)CC(C)(C)N1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20150353553A1,CON(C)C(=O)C1CC(F)(F)C1.C[Mg]Br>>CC(=O)C1CC(F)(F)C1,,CCOCC,,,,val
US05965763,CC(C)(C)[Si](Oc1ccc(-c2c(Cl)cc(C=O)cc2Cl)cc1)(c1ccccc1)c1ccccc1>>O=Cc1cc(Cl)c(-c2ccc(O)cc2)c(Cl)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050009907A1,NO.O=Cc1ccc(-c2ccc(O)cc2)c2sccc12>>ON=Cc1ccc(-c2ccc(O)cc2)c2sccc12,,CCOCC,CO,Cl,c1ccncc1,val
US20100210672A1,COc1ncc(-c2nc(C)cs2)c(OC)n1>>Cc1csc(-c2c[nH]c(=O)[nH]c2=O)n1,,C1COCCO1,Cl,,,val
US20040171634A1,C[Si](C)(C)CCOCn1nc(C=Cc2ccccc2)c2ccc(C(O)c3ccccc3)cc21>>C[Si](C)(C)CCOCn1nc(C=Cc2ccccc2)c2ccc(C(=O)c3ccccc3)cc21,,CCCCCC,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20080045526A1,CCC1OC(=C2C(=O)Nc3ccc(F)cc32)c2cnc(Cl)c(Cl)c21.NCCN1CCOCC1>>CCC1OC(=C2C(=O)Nc3ccc(F)cc32)c2cnc(NCCN3CCOCC3)c(Cl)c21,,C1COCCO1,,O,,val
US20050054657A1,COCOc1ccc(B2OC(C)(C)C(C)(C)O2)c2c1Sc1ccccc1S2.O=c1cc(Cl)oc(N2CCOCC2)c1>>COCOc1ccc(-c2cc(=O)cc(N3CCOCC3)o2)c2c1Sc1ccccc1S2,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20130190289A1,CCN1CCC[C@H](NC(=O)OC(C)(C)C)C1=O.Cl>>CCN1CCC[C@H](N)C1=O.Cl,,C1COCCO1,CCOCC,,,val
US20110082294A1,CC(C)(C)OC(=O)N1CCC2(CC2)C(F)(F)C1.Cl>>Cl.FC1(F)CNCCC12CC2,,CCO,,,,val
US20140243302A1,CB(O)O.COc1ccc2ncc(C#N)c(Br)c2n1>>COc1ccc2ncc(C#N)c(C)c2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20160244429A1,COc1ccc2[nH]cc(CCCCOS(=O)(=O)c3ccc(C)cc3)c2c1.O=c1ccccn1-c1ccc(N2CCNCC2)cc1>>COc1ccc2[nH]cc(CCCCN3CCN(c4ccc(-n5ccccc5=O)cc4)CC3)c2c1,,CC#N,,[I-].[K+],,val
US20040127576A1,CCCCC1=C2CCc3cc(O)ccc3C2(C)CCC1=O>>CCCCC1=C2CCc3cc(O)ccc3C2(C)CCC1,,CC#N,,,,val
US20090209607A1,CCCc1sc(C(=O)O)cc1-c1c(Br)cnn1C.N[C@@H](Cc1ccccc1C(F)(F)F)CN1C(=O)c2ccccc2C1=O>>CCCc1sc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)cc1-c1c(Br)cnn1C,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20090062282A1,CN(C)C=Nc1nc(CCc2cccc(-c3ccco3)c2)cc(=O)[nH]1.O=C(NCCO)OCc1ccccc1>>CN(C)/C=N/c1nc(CCc2cccc(-c3ccco3)c2)cc(=O)n1CCNC(=O)OCc1ccccc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030158218A1,CCOC(=O)OCC.CSc1nccc(C)n1>>CCOC(=O)Cc1ccnc(SC)n1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US05789440,CC(C)(O)C#N.O=C(Cl)c1ccccc1.O=C1C=C(O)CC(c2ccccc2)(c2ccccc2)O1>>O=C1OC(c2ccccc2)(c2ccccc2)CC(O)=C1C(=O)C(=O)c1ccccc1,,CCOCC,ClCCl,CCN(CC)CC,,val
US05243049,O=C(OO)c1cccc(Cl)c1.O=C1c2cnc3ccccc3c2CN1c1ccccc1>>O=C1c2c(c3ccccc3[nH]c2=O)CN1c1ccccc1,,ClCCl,,,,val
US20080051416A1,Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cc1C(=O)O.NCCCCc1ccccc1>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cc1C(=O)NCCCCc1ccccc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05631279,CI.COc1ccccc1CC(=O)N1C(=O)O[C@H](c2ccccc2)[C@H]1C>>COc1ccccc1[C@@H](C)C(=O)N1C(=O)O[C@H](c2ccccc2)[C@H]1C,,C1CCOC1,CCOC(C)=O,CC(=O)O,,val
US20090318408A1,CI.O=C1Nc2cnc(Cl)nc2N(C2CCCC2)CC1(Cl)Cl>>CN1C(=O)C(Cl)(Cl)CN(C2CCCC2)c2nc(Cl)ncc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05750549,CNC1CCC(OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1c1ccccc1.NC(=O)CI>>CN(CC(N)=O)C1CCC(OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1c1ccccc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20130029938A1,CC(C)(C)OC(=O)[C@@H](N)CO.CCCC[C@]1(CC)CS(=O)(=O)c2cc(C=O)c(OC)cc2[C@@H](c2ccccc2)N1>>CCCC[C@]1(CC)CS(=O)(=O)c2cc(CN[C@@H](CO)C(=O)O)c(OC)cc2[C@@H](c2ccccc2)N1,,ClCCl,,C1COCCO1,Cl,val
US06610705B1,COc1ccc(C(c2ccc(O)c(C)c2)c2cccc3c2CCCC3)cc1.ClCCN1CCCCC1>>COc1ccc(C(c2ccc(OCCN3CCCC3)c(C)c2)c2cccc3c2CCCC3)cc1,,CC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US06002008,CCOc1cc2c(Cl)c(C#N)cnc2cc1OC.Nc1cccc(Br)c1>>CCOc1cc2c(Nc3cccc(Br)c3)c(C#N)cnc2cc1OC,,CCO,,O=C([O-])O.[Na+],,val
US20020156295A1,Brc1ccccc1I.OB(O)c1ccc(C(F)(F)F)cc1>>FC(F)(F)c1ccc(-c2ccccc2Br)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US07094798B1,CC(C)(C)[Si](C)(C)OCCCBr.COc1ccc2[nH]c(C=Cc3ccccc3Cl)cc2c1>>COc1ccc2c(c1)cc(C=Cc1ccccc1Cl)n2CCCO[Si](C)(C)C(C)(C)C,,CN(C)C=O,O,[H-].[Na+],,val
US20060063782A1,O=[N+]([O-])c1ccc(Cl)c(CBr)c1.Oc1cccnc1>>O=[N+]([O-])c1ccc(Cl)c(COc2cccnc2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20020143023A1,CC1=C(C(=O)O)C(c2cccc(Cl)c2)NC(=O)N1.NCCCn1ccnc1>>CC1=C(C(=O)NCCCn2ccnc2)C(c2cccc(Cl)c2)NC(=O)N1,,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20150353537A1,CC(C)(C)OC(=O)N1CC(C)(C)c2cc(C#N)c(Cc3ccc(F)cc3)cc21>>CC1(C)CNc2cc(Cc3ccc(F)cc3)c(C#N)cc21,,C1COCCO1,Cl,,,val
US20040048868A1,CCOc1cc2[nH]c(-c3nn(C4CCCCO4)cc3NC(=O)C3CC3)nc2cc1F>>CCOc1cc2[nH]c(-c3n[nH]cc3NC(=O)C3CC3)nc2cc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090048203A1,Nc1nc(/C=C/c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O>>Nc1nc(CCc2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O,[Pd],CCOC(C)=O,CO,[H][H],,val
US20100113422A1,CO.Clc1cccc(Cc2nc(Cl)c3c(n2)CCN(Cc2ccccc2)CC3)c1>>COc1nc(Cc2ccccc2)nc2c1CCN(Cc1ccccc1)CC2,,CO,,C[O-].[Na+],,val
US20050176701A1,CCc1cc(CCC2(C3CCCC3)CC(=O)CC(=O)O2)cc(F)c1O.Cc1cc(C)n2nc(C=O)nc2n1>>CCc1cc(CCC2(C3CCCC3)CC(O)=C(Cc3nc4nc(C)cc(C)n4n3)C(=O)O2)cc(F)c1O,,CO,,,,val
US04107170,C1CN1.c1ccc(C2CO2)cc1>>OC(CN1CC1)c1ccccc1,O,,,[K+].[OH-],,val
US20100075976A1,CN(CC=O)C(=O)OC(C)(C)C.Fc1ccc(-c2nccnc2N2CCNCC2)cc1>>CN(CCN1CCN(c2nccnc2-c2ccc(F)cc2)CC1)C(=O)OC(C)(C)C,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110095281A1,O=[N+]([O-])c1cccc2ccc(-c3ccc4ccccc4n3)cc12>>Nc1cccc2ccc(-c3ccc4ccccc4n3)cc12,[Pd],CO,,Cl,[BH4-].[Na+],val
US20120059028A1,COC(=O)C(OC(C)(C)C)c1c(C)nc2sc3c(c2c1I)CCCC3.OB(O)c1ccc2c3c(ccnc13)CCO2>>COC(=O)C(OC(C)(C)C)c1c(C)nc2sc3c(c2c1-c1ccc2c4c(ccnc14)CCO2)CCCC3,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20120059002A1,CC(C)(C)[Si](C)(C)OCCBr.Cc1cc(C=O)cc(C)c1O>>Cc1cc(C=O)cc(C)c1OCCO[Si](C)(C)C(C)(C)C,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20040176374A1,CC(=O)Nc1cccc(-c2nc(-c3ccc(S(=O)(=O)Nc4cccc(NC(=O)C(C)(C)CF)c4)cc3)no2)n1>>CC(C)(CF)C(=O)Nc1cccc(NS(=O)(=O)c2ccc(-c3noc(-c4cccc(N)n4)n3)cc2)c1,,O,,Cl,,val
US20060241147A1,CN1CCNCC1.COC(=O)c1ccc(CCl)cc1>>COC(=O)c1ccc(CN2CCN(C)CC2)cc1,,CC(C)=O,,[I-].[Na+],,val
US20160096839A1,C[C@@H]1CCC[C@H](NC(=O)OC(C)(C)C)c2cncc(c2)-c2ccncc2NC1=O>>C[C@@H]1CCC[C@H](N)c2cncc(c2)-c2ccncc2NC1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070244132A1,CCn1ccc2ncnc(Cl)c21.Nc1ccc(OCc2cccc(F)c2)c(Cl)c1>>CCn1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c21,,CN1CCCC1=O,,,,val
US05019574,CCNc1nc2ccccc2c([N+](=O)[O-])c1N1CCOCC1>>CCNc1nc2ccccc2c(N)c1N1CCOCC1,[Pd],C1CCOC1,,,,val
US20120101100A1,CCNC(=O)Nc1cc(-c2nc(-c3cccc(OC)n3)cs2)c(-c2cncc(C(=O)NNC(=O)OC(C)(C)C)n2)cn1>>CCNC(=O)Nc1cc(-c2nc(-c3cccc(OC)n3)cs2)c(-c2cncc(C(=O)NN)n2)cn1,,CO,,CC(=O)Cl,,val
US20110281874A1,CC(C)(C)OC(=O)N1CCN(Cc2csc(Nc3ncc(Br)cc3Oc3ccc(F)cc3)n2)C(=O)C1>>O=C1CNCCN1Cc1csc(Nc2ncc(Br)cc2Oc2ccc(F)cc2)n1,,CCOCC,ClCCl,C1COCCO1,Cl,val
US20050148659A1,CC1(C)C=Cc2cc(CC(=O)O)ccc2O1.NC1CCCc2ccccc21>>CC1(C)C=Cc2cc(CC(=O)NC3CCCc4ccccc43)ccc2O1,,C1CCOC1,,,,val
US04348399,CCCCCCCCCCCCCCCCNc1ccc(CCC(=O)Cl)cc1.CCOCCO>>CCCCCCCCCCCCCCCCNc1ccc(CCC(=O)OCCOCC)cc1,CN(C)c1ccncc1,ClCCl,,Cl,,val
US20070111998A1,O=S(=O)(Cl)c1cccc(C(F)(F)F)c1.OC(COc1cccc2[nH]c3ccccc3c12)CN1CCNCC1>>O=S(=O)(c1cccc(C(F)(F)F)c1)N1CCN(CC(O)COc2cccc3[nH]c4ccccc4c23)CC1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20020120148A1,CI.O=C1CCCCc2ccc(O)cc21>>COc1ccc2c(c1)C(=O)CCCC2,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04406690,O=[N+]([O-])c1ccc(Cl)nc1.OCCc1ccc(Cl)cc1>>O=[N+]([O-])c1ccc(OCCc2ccc(Cl)cc2)nc1,,CS(C)=O,,[H-].[Na+],,val
US05147880,CC(C)N(CCCl)C(C)C.COc1ccc2c(c1)C(c1ccc(O)cc1)c1c-2ccc2ccccc12>>COc1ccc2c(c1)C(c1ccc(OCCN(C(C)C)C(C)C)cc1)c1c-2ccc2ccccc12,,CCC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US03962445,O=[N+]([O-])O.O=c1cc(O)c2cc(Br)ccc2[nH]1>>O=c1[nH]c2ccc(Br)cc2c(O)c1[N+](=O)[O-],,CC(=O)O,,,,val
US04960789,Cc1cc(F)ccc1CC(Cl)C#N>>Cc1cc(F)ccc1C=CC#N,,C1CCOC1,,,,val
US20050137236A1,CC(C)N.O=C(O)c1ccc(Br)cc1F>>CC(C)Nc1cc(Br)ccc1C(=O)O,,c1ccncc1,,Cl,,val
US20030055244A1,CCOC(=O)[C@H](CCC(=O)O)NC(=O)OCc1ccccc1.c1cc(N2CCC3(CCNC3)CC2)ccn1>>CCOC(=O)[C@H](CCC(=O)N1CCC2(CCN(c3ccncc3)CC2)C1)NC(=O)OCc1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090239928A1,CC(C)(C)OC(=O)N1CC[C@H](NCC2CCC2)C1.O=C(Cl)c1ccccc1Oc1ccccc1>>CC(C)(C)OC(=O)N1CC[C@H](N(CC2CCC2)C(=O)c2ccccc2Oc2ccccc2)C1,,ClCCl,,CCN(CC)CC,,val
US04782155,CCOC(CN)OCC.O=Cc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1>>CCOC(CN=Cc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1)OCC,,c1ccccc1,,,,val
US20110306597A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC1CCCN(Cc2ccccc2)C1>>CC(C)(C)OC(=O)NCC1CCCN(Cc2ccccc2)C1,,CC#N,,CCN(CC)CC,,val
US20160022619A1,CCOC(=O)[C@H]1C[C@H]1c1ccc(N(CCC(F)(F)F)C2CCCCC2)c(N)c1.Cc1cc(N)no1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CCOC(=O)[C@H]1C[C@H]1c1ccc(N(CCC(F)(F)F)C2CCCCC2)c(NC(=O)Nc2cc(C)on2)c1,,C1CCOC1,,CCN(CC)CC,,val
US20120101127A1,CC(C)S(=O)(=O)Cl.CC1(C)CC(c2cccc(N)c2)Nc2ccc(C#N)cc21>>CC(C)S(=O)(=O)Nc1cccc(C2CC(C)(C)c3cc(C#N)ccc3N2)c1,,ClCCl,,c1ccncc1,,val
US06399619B1,CC(C)(C)OC(=O)N1CCC(C=O)CC1.CCOP(=O)(CC(=O)c1ccccc1)OCC>>CC(C)(C)OC(=O)N1CCC(C=CC(=O)c2ccccc2)CC1,,C1CCOC1,,[H-].[Na+],,val
US20090048269A1,COc1cc(N)cc(OC)c1OC.Cc1ccc(Oc2ccnc(Cl)c2)c(-c2cnccn2)n1>>COc1cc(Nc2cc(Oc3ccc(C)nc3-c3cnccn3)ccn2)cc(OC)c1OC,,CC(=O)N(C)C,CCOC(C)=O,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US04213999,CCOC(=O)C(Br)C(=O)OCC.O=Cc1cc(Cc2ccccc2)ccc1O>>CCOC(=O)c1cc2cc(Cc3ccccc3)ccc2o1,,CCC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120208798A1,CC(=O)N1c2ccc(B3OC(C)(C)C(C)(C)O3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.Cc1nnc(Br)s1>>CC(=O)N1c2ccc(-c3nnc(C)s3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[K+].[K+],val
US20020091261A1,Clc1nnc(Cc2ccncc2)c2ccccc12.NC1CCCC1>>c1ccc2c(NC3CCCC3)nnc(Cc3ccncc3)c2c1,,ClCCl,,O=C([O-])O.[Na+],,val
US20100197674A1,C#CCNc1ccccc1N.CCOC(=O)C(=O)C(=O)OCC>>C#CCn1c(=O)c(C(=O)OCC)nc2ccccc21,,Cc1ccccc1,,,,val
US03963718,NCC(O)c1ccc(Cl)c(Cl)c1.O=[N+]([O-])NC1=NCCN1>>OC(CNC1=NCCN1)c1ccc(Cl)c(Cl)c1,,CC(C)=O,,Cc1ccccc1C,,val
US20050209454A1,CC(C)(C)OC(=O)N1CCOCC1CO.CCN(CC)CC.Cc1c(C(=O)O)cn2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c12.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCc1c(NC(=O)OC[C@@H]2COCCN2C(=O)OC(C)(C)C)cn2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c12,,C1CCOC1,Cc1ccccc1,O,,val
US05324743,C=CCc1cc(Oc2cccc(C(=O)OCC)c2)ccc1O>>CCCc1cc(Oc2cccc(C(=O)OCC)c2)ccc1O,[Pd],CO,,,,val
US04042617,C=C(c1ccc(-c2ccccc2)cc1)C(O)C(=O)OC>>COC(=O)C(=O)C(C)c1ccc(-c2ccccc2)cc1,,CO,,CC(=O)O,[Na],val
US20110245239A1,Cc1cc(C2OCCO2)sc1C(=O)NCC(F)(F)F>>Cc1cc(C=O)sc1C(=O)NCC(F)(F)F,,CC(C)=O,,Cl,,val
US20090062282A1,CC(=O)Cl.NCCn1c(N)nc(CCc2cccc(-c3ccco3)c2)cc1=O>>CC(=O)NCCn1c(N)nc(CCc2cccc(-c3ccco3)c2)cc1=O,,CN(C)C=O,ClCCl,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20100041645A1,CC(C(=O)O)c1cccc([N+](=O)[O-])c1.N#Cc1ccc(N)cc1>>N#Cc1ccc(NC(=O)CCc2cccc([N+](=O)[O-])c2)cc1,,CCOC(C)=O,Cc1ccccc1,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US20100152163A1,Cc1ccc2[nH]c3c(c2c1)CCN(C)CC3.O=C(CCl)N1CCCCC1>>Cc1ccc2c(c1)c1c(n2CC(=O)N2CCCCC2)CCN(C)CC1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20090053142A1,CN(CCCC(CCN(C)Cc1ccccc1)CN(C)Cc1ccccc1)Cc1ccccc1>>CNCCCC(CCNC)CNC,[Pd],,,[H][H],,val
US20160159815A1,CC(C)(C)[Si](C)(C)Cl.N#C[C@]1(c2ccccn2)C[C@@H]1CO>>CC(C)(C)[Si](C)(C)OC[C@H]1C[C@]1(C#N)c1ccccn1,,ClCCl,,c1c[nH]cn1,,val
US20060183762A1,CCOC(=O)c1cc(F)c(N2CC[C@H](NC(=O)OC(C)(C)C)C2)c(Cl)c1F.NC1CC1>>CCOC(=O)c1cc(F)c(N2CC[C@H](NC(=O)OC(C)(C)C)C2)c(Cl)c1NC1CC1,,CCOC(C)=O,,CS(C)=O,,val
US20070299186A1,O=C(c1ccccc1)c1ccc(F)cc1.Oc1ccc(I)cc1>>O=C(c1ccccc1)c1ccccc1Oc1ccc(I)cc1,,Cc1ccccc1,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150119362A1,CCc1cc(Cc2ccc(C(C)(C)C(=O)OC)cc2)nc(-c2cccc(Cl)c2)n1>>CCc1cc(Cc2ccc(C(C)(C)CO)cc2)nc(-c2cccc(Cl)c2)n1,,C1CCOC1,,,,val
US20140315933A1,N#Cc1cc(S(=O)(=O)Nc2nccs2)ccc1F.N#Cc1ccc(O)cc1Cl>>N#Cc1ccc(Oc2ccc(S(=O)(=O)Nc3nccs3)cc2C#N)cc1Cl,,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20100029621A1,CC(C)(C)OC(=O)N1CC[C@@H](N)C1.CC(C)(C)[Si](C)(C)OC(c1ccc(CN2CCN(C(=O)c3ccc(N)c(F)c3)CC2)cc1)(C(F)(F)F)C(F)(F)F.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)Nc2ccc(C(=O)N3CCN(Cc4ccc(C(O[Si](C)(C)C(C)(C)C)(C(F)(F)F)C(F)(F)F)cc4)CC3)cc2F)C1,,ClCCl,,,,val
US20110130406A1,CC(C)(C)OC(=O)N1CC=CCC1.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>CC(C)(C)OC(=O)N1CC[C@H](O)[C@H](O)C1,O=[Os](=O)(=O)=O,,,CC(C)=O,,val
US20150239900A1,COC(=O)c1c(N)cc(Br)cc1F.O=C1CCC(=O)N1Cl>>COC(=O)c1c(N)cc(Br)c(Cl)c1F,,CC(C)O,,,,val
US20070238741A1,O=S(Cl)Cl.Oc1nc(-c2cc3ccccc3s2)nc2ncccc12>>Clc1nc(-c2cc3ccccc3s2)nc2ncccc12,,ClC(Cl)Cl,,CN(C)C=O,,val
US20020094989A1,CCC(CC)(C(=O)OCc1ccccc1)C(=O)OCc1ccccc1>>CCC(C=O)(CC)C(=O)OCc1ccccc1,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20150005295A1,COC(=O)C(C(=O)OC)=C(c1ccc(F)c(F)c1)C(F)F.N=C(N)c1ncc(F)cc1F>>COC(=O)C1C(=O)NC(c2ncc(F)cc2F)=NC1(c1ccc(F)c(F)c1)C(F)F,,C1COCCO1,,,,val
US20060178407A1,O=[N+]([O-])c1ccc(S)nc1.OCCBr>>O=[N+]([O-])c1ccc(SCCO)nc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090318486A1,C=CC(=O)OC(C)(C)C.O=C1CC2(C(=O)Nc3ccc(Cl)cc32)C(=O)N1Cc1ccccc1>>CC(C)(C)OC(=O)CCN1C(=O)C2(CC(=O)N(Cc3ccccc3)C2=O)c2cc(Cl)ccc21,,C1CCOC1,,O,[H-].[Na+],val
US20040002526A1,Nc1ccccc1.O=C(O)CSC(=S)SCC(=O)O>>O=C1CSC(=S)N1c1ccccc1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20030153553A1,CC(=O)OC(C)=O.Cc1cc(N2CCCC2)c2cc(N3CCCC3)c(N)cc2n1.Cl>>CC(=O)Nc1cc2nc(C)cc(N3CCCC3)c2cc1N1CCCC1.Cl,,CC(=O)O,,,,val
US20130102599A1,CC(C)(C)OC(=O)NN.CC1OCC=CC1=O>>CC1OCCCC1=NNC(=O)OC(C)(C)C,[Pd],CO,,CC(=O)O,,val
US05576324,COc1ccc(C(=O)Cl)cc1OC.Cc1cc2c(c3c1NC(=O)CC3)OC(CN1CCNCC1)C2>>COc1ccc(C(=O)N2CCN(CC3Cc4cc(C)c5c(c4O3)CCC(=O)N5)CC2)cc1OC,,c1ccncc1,,,,val
US20140073792A1,CCOC(=O)C(C)(C)c1ncccc1Oc1cnc2c(F)cccc2c1>>CC(C)(C(=O)O)c1ncccc1Oc1cnc2c(F)cccc2c1,,CCO,,Cl,[Na+].[OH-],val
US05202344,CCCCCN1CC(C(=O)OCC)=C(O)C1=O.NO>>CCCCCN1CC(C(=O)OCC)C(=NO)C1=O,,c1ccncc1,,Cl,,val
US20080045530A1,C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)O.NS(=O)(=O)c1cccc(OCc2ccccc2)c1>>C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)NS(=O)(=O)c1cccc(OCc2ccccc2)c1,,C1CCOC1,CCOC(C)=O,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US06143764,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.COc1ccc(N)cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1ccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1OC,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20070032494A1,CC(C)c1cc(Cc2c(Cl)cc(N3C(=O)c4ccccc4C3=O)cc2Cl)n[nH]c1=O.COC(OC)N(C)C>>CC(C)c1cc(Cc2c(Cl)cc(N3C(=O)c4ccccc4C3=O)cc2Cl)nn(C)c1=O,,ClCCl,,,,val
US20100137313A1,CCI.CCO.O=C(O)c1cc(Br)cnc1O>>CCOC(=O)c1cc(Br)cn(CC)c1=O,,CO,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080085890A1,COC=C1C(=O)NC(=O)c2ccc(Br)cc21.NCCCN1CCCC1>>O=C1NC(=O)c2ccc(Br)cc2/C1=C/NCCCN1CCCC1,,CCOCC,,CN(C)C=O,,val
US20100075953A1,c1ccc(COc2ccc(CCN3CCN(c4cccc5cccnc45)CC3)cc2)cc1>>Oc1ccc(CCN2CCN(c3cccc4cccnc34)CC2)cc1,,ClCCl,,BrB(Br)Br,,val
US20140094462A1,C=CCCC(=O)N[C@H]1CCC[C@H]1OC(=O)[C@H](C)CC=C>>C[C@@H]1CC=CCCC(=O)N[C@H]2CCC[C@H]2OC1=O,,Cc1ccccc1,,,,val
US04317830,BrCC1CCCCCC1.c1c[nH]cn1>>c1cn(CC2CCCCCC2)cn1,,CCCCO,,CC(C)(C)[O-].[K+],,val
US20110306589A1,C1CNC1.Cn1ncc([N+](=O)[O-])c1C(=O)O>>Cn1ncc([N+](=O)[O-])c1C(=O)N1CCC1,,CCOC(C)=O,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20120184562A1,CC(C)(C)OC(=O)NCCC(N)c1ccccc1.COc1ccc2cc(C(=O)Nc3cc(C(=O)O)ccc3C)c(=O)[nH]c2n1>>COc1ccc2cc(C(=O)Nc3cc(C(=O)NC(CCNC(=O)OC(C)(C)C)c4ccccc4)ccc3C)c(=O)[nH]c2n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040138286A1,O=[N+]([O-])c1ccccc1Oc1ccc2[nH]ncc2c1>>Nc1ccccc1Oc1ccc2[nH]ncc2c1,,CCOC(C)=O,CO,,,val
US06020340,COc1ccc(C(=O)O)c2cc(C(C)C)oc12.Nc1cccnc1N>>COc1ccc(-c2nc3ncccc3[nH]2)c2cc(C(C)C)oc12,,O=P(Cl)(Cl)Cl,,,,val
US04062978,C=CCBr.CC(=O)CCc1ccc(O)cc1>>C=CCOc1ccc(CCC(C)=O)cc1,,CCO,,O,[K+].[OH-],val
US20150025238A1,COc1c(Cl)ccc(-c2nc(C(=O)OCc3ccccc3)c(/C=C/[Si](C)(C)C)c(N)c2F)c1F.O=C1CCC(=O)N1Cl>>COc1c(Cl)ccc(-c2nc(C(=O)OCc3ccccc3)c(/C=C/Cl)c(N)c2F)c1F,,CN(C)C=O,O,,,val
US05443698,CC(C)(C)CCCCCC(=O)O.[Ag]>>CC(C)(C)CCCCCC(=O)[O-].[Ag+],,CC(C)=O,,[Na+].[OH-],,val
US20070087346A1,BrBr.COc1ccc2c(c1)CC1(Cc3ccc(Cl)cc3)CCC(=O)C=C21>>COc1ccc2c(c1)CC1(Cc3ccc(Cl)cc3)CCC(=O)C(Br)=C21,,ClC(Cl)(Cl)Cl,,O=C([O-])O.[Na+],,val
US20070208054A1,CC1(C)COB(c2ccc(CCCC(=O)O)cc2)OC1>>O=C(O)CCCc1ccc(B(O)O)cc1,,CCOCC,,[Na+].[OH-],,val
US20090281149A1,NCCOc1cccc(C#CC2(O)CCSCC2)c1>>NCCOc1cccc(CCC2(O)CCSCC2)c1,,CCOC(C)=O,CO,,,val
US20140135359A1,Cc1ccccc1.O=Cc1cc(O)cc(C=O)n1.[Li]CCCC>>CC(C)=Cc1cc(O)cc(C=C(C)C)n1,,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150210682A1,COc1ccc(CC(C)NC=O)cc1OCc1ccccc1>>COc1cc2c(cc1OCc1ccccc1)CC(C)N=C2,,CC#N,,O=P(Cl)(Cl)Cl,,val
US20110021537A1,CCOC(=O)N1CCN(C(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)OCc3ccccc3)n(-c3cccc(F)c3)n2)CC1>>CCOC(=O)N1CCN(C(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)O)n(-c3cccc(F)c3)n2)CC1,,CCOC(C)=O,,,,val
US20060166990A1,C1COCCO1.Cc1ccc(I)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl.c1coc(P(c2ccco2)c2ccco2)c1>>Cc1ccc(C=CCO)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl,,C1COCCO1,,CC#N,,val
US20050277671A1,CC(C)(C)OC(=O)NCC1CCN(CC2(C(=O)O)CCOCC2)CC1.Cc1ccc(S(=O)(=O)O)cc1>>Cc1ccc(S(=O)(=O)O)cc1.NCC1CCN(CC2(C(=O)O)CCOCC2)CC1,,CC(C)O,,CCN(CC)CC,O,val
US04582775,CI.Cc1nnc(S)n1-c1ccccc1>>CSc1nnc(C)n1-c1ccccc1,,CO,,C[O-].[Na+],,val
US20030153566A1,COCCN(C)c1ccc(OC)c(NC(=S)NC(=O)c2ccccc2)c1>>COCCN(C)c1ccc(OC)c(NC(N)=S)c1,,CO,,C[O-].[Na+],,val
US20160122331A1,COC(=O)c1ccc(C2CC(=O)CC(C)(C)O2)cc1>>COC(=O)c1ccc([C@H]2C[C@H](O)CC(C)(C)O2)cc1,,CO,,[BH4-].[Na+],,val
US20090124604A1,COC(=O)c1ccc(C)c(N)c1.COC(OC)OC.Nc1c(C(=O)O)cc(I)cc1C(=O)O>>COC(=O)c1ccc(C)c(-n2cnc3c(C(=O)O)cc(I)cc3c2=O)c1,,Cc1ccccc1,,CC(=O)O,,val
US20120058988A1,COC(=O)c1cc(Br)nc2c1[nH]c1cc(N)ccc12.N>>NC(=O)c1cc(Br)nc2c1[nH]c1cc(N)ccc12,,CO,,,,val
US20090197863A1,COC(=O)c1cccc2nc(-c3cccc(C(=O)N4CCN(C(=O)C5CC5)CC4)c3)oc12.[NH4+]>>NC(=O)c1cccc2nc(-c3cccc(C(=O)N4CCN(C(=O)C5CC5)CC4)c3)oc12,,CO,,,,val
US20090197863A1,CCC=O.NC(=O)c1cccc2nc(C3CCCNC3)oc12>>CCCN1CCCC(c2nc3cccc(C(N)=O)c3o2)C1,[Pd],CO,,[H][H],,val
US20040127574A1,O=C(O)C(Cc1cccc(C(F)(F)F)c1)C(O)c1ccc(F)cc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>O=C1NC(Cc2cccc(C(F)(F)F)c2)C(c2ccc(F)cc2)O1,,C1CCOC1,,CCN(CC)CC,O,val
US20160257658A1,NC(N)=S.O=C(CBr)c1ccc(Br)cc1>>Nc1nc(-c2ccc(Br)cc2)cs1,,CCO,,,,val
US20030045560A1,CN(Cc1ccc2c(Br)c(O)ccc2c1)C(=O)c1ccc(C2CCCCC2)cc1.COC(=O)C(Cc1ccccc1)OS(=O)(=O)C(F)(F)F>>COC(=O)C(Cc1ccccc1)Oc1ccc2cc(CN(C)C(=O)c3ccc(C4CCCCC4)cc3)ccc2c1Br,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100310675A1,Cc1cc(Nc2cc(N3CCC3)nc(Sc3ccc(C(=O)O)cc3)n2)[nH]n1.NC1CCCC1>>Cc1cc(Nc2cc(N3CCC3)nc(Sc3ccc(C(=O)NC4CCCC4)cc3)n2)[nH]n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20140248268A1,CC(C)(C)OC(=O)c1c(NC(=S)NC(=O)c2ccc(F)cc2)sc2c1CC(C)(C)OC2>>CC1(C)Cc2c(sc(NC(=S)NC(=O)c3ccc(F)cc3)c2C(=O)O)CO1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20110172245A1,CC(=O)Oc1cccc(C(=O)Nc2ccc(C(F)(F)F)cc2)c1>>O=C(Nc1ccc(C(F)(F)F)cc1)c1cccc(O)c1,,CO,,C1CCOC1,[Na+].[OH-],val
US20120015962A1,COc1cc2nc(Cl)ccc2cc1[N+](=O)[O-].NCCO>>COc1cc2nc(NCCO)ccc2cc1[N+](=O)[O-],,C1COCCO1,,,,val
US04734418,CCN1CCC(=O)C(=COC)C1=O.N=C(N)N1CCN(Cc2ccccc2)CC1>>CCN1CCc2nc(N3CCN(Cc4ccccc4)CC3)ncc2C1=O,,CCO,,O=S(=O)(O)O,[Na+].[OH-],val
US05206400,CCOCC.O=C(Cl)/C=C/C(=O)Cl>>O=C(Cl)[C@@H]1CC=CC[C@H]1C(=O)Cl,,CCOCC,,,,val
US05618839,CC1(C)CC(=O)c2ccccc21.O=[N+]([O-])O>>CC1(C)CC(=O)c2cc([N+](=O)[O-])ccc21,,O=S(=O)(O)O,,,,val
US05587503,C#C.CO[Si](C)(CCCO)OC>>C=COCCC[Si](C)(OC)OC,,CS(C)=O,,[K+].[OH-],,val
US20060211734A1,Clc1cccc(Cl)n1.OC1CCN(CC2CC2)CC1>>Clc1cccc(OC2CCN(CC3CC3)CC2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20120202691A1,COC(=O)CCC(=O)CBr.Cc1cc(-c2ccc(Cl)cc2)n[nH]1>>COC(=O)CCC(=O)Cn1nc(-c2ccc(Cl)cc2)cc1C,,CN(C)C=O,,O,[H-].[Na+],val
US20150307521A1,COc1cnc2c(Cl)nccc2c1.NC1=N[C@@]2(CCS1)c1cc(N)ccc1Oc1cnc(C3=CCCOC3)cc12>>COc1cnc2c(Nc3ccc4c(c3)[C@@]3(CCSC(N)=N3)c3cc(C5=CCCOC5)ncc3O4)nccc2c1,,CC(C)O,,O=S(=O)(O)O,[Na+].[OH-],val
US20100197715A1,C1CCOC1.CN1CC(c2ccccc2)([N+](=O)[O-])CCC1=O>>CN1CC(c2ccccc2)([N+](=O)[O-])CC(O)C1=O,,CCCCCC,,CC(C)NC(C)C,[Li]CCCC,val
US20020120139A1,CCOC(=O)C(C=O)Cc1cncnc1.NC(N)=S>>O=c1[nH]c(=S)[nH]cc1Cc1cncnc1,,CCO,,[Na],,val
US20140100231A1,COc1nnc(C(C)(F)F)cc1Cn1cnc(C(F)(F)F)c(Oc2cc(Cl)cc(C#N)c2)c1=O>>CC(F)(F)c1cc(Cn2cnc(C(F)(F)F)c(Oc3cc(Cl)cc(C#N)c3)c2=O)c(=O)[nH]n1,,CC#N,,C[Si](C)(C)Cl,,val
US04965398,C=C1CCCCC1.COC(=O)C=O>>COC(=O)[C@@H](O)CC1=CCCCC1,,O=C([O-])O,[Na+],,,val
US05011947,CCOC(=O)C(C)C(O)(c1ccc(F)cc1)c1ccc(F)cc1>>CCOC(=O)C(C)=C(c1ccc(F)cc1)c1ccc(F)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070185184A1,CC(C)C(=O)OC(=O)C(C)C.N#Cc1ccc(-n2ccc3ccccc32)c(Cl)c1>>CC(C)C(=O)c1cn(-c2ccc(C#N)cc2Cl)c2ccccc12,,C[N+](=O)[O-],,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US20050014792A1,Cc1ccccc1-c1cc(O)ncc1C#N.O=P(Cl)(Cl)Cl>>Cc1ccccc1-c1cc(Cl)ncc1C#N,,ClCCl,,,,val
US07015218B1,C1CCN(N2CCCCC2)CC1.N#Cc1cc([N+](=O)[O-])ccc1Cl>>N#Cc1cc([N+](=O)[O-])ccc1N1CCC(N2CCCCC2)CC1,,CCO,,,,val
US20060128685A1,CCOC(=O)C1CN(C(=O)OC(C)(C)C)CCN1C(=O)OC(C)(C)C>>CCOC(=O)C1CN(C(=O)OC(C)(C)C)CCN1,,CCO,,Cl,,val
US20050209235A1,CC(=O)OCC(=O)Cl.NC1CCN(Cc2ccn3ncnc(Nc4ccc5c(cnn5Cc5cccc(F)c5)c4)c23)CC1>>CC(=O)OCC(=O)NC1CCN(Cc2ccn3ncnc(Nc4ccc5c(cnn5Cc5cccc(F)c5)c4)c23)CC1,,ClCCl,,CCN(CC)CC,,val
US20140038999A1,CC(C)C[C@@H](C=O)NC(=O)OC(C)(C)C.C[Mg]Br>>CC(C)C[C@H](NC(=O)OC(C)(C)C)C(C)O,,CCOCC,,,,val
US20110130380A1,C[C@@H](N)C1CCOCC1.Fc1cccc(Br)n1>>C[C@@H](Nc1cccc(Br)n1)C1CCOCC1,,O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20140249139A1,CC(=O)N1CCN(C(=O)c2cc(-c3ncnc4ccc(Br)cc34)ccc2C)CC1.COc1ccc(B(O)O)cn1>>COc1ccc(-c2ccc3ncnc(-c4ccc(C)c(C(=O)N5CCN(C(C)=O)CC5)c4)c3c2)cn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US04332816,Br.O=C(NC1CC(=O)N(c2cc(Cl)cc(Cl)c2)C1=O)OCc1ccccc1>>Br.NC1CC(=O)N(c2cc(Cl)cc(Cl)c2)C1=O,,CCOCC,,CC(=O)O,,val
US20150087646A1,COc1ccc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)cc1C(=O)O.NC1(c2ccc(C(F)(F)F)cc2)CC1>>COc1ccc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)cc1C(=O)NC1(c2ccc(C(F)(F)F)cc2)CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US03974156,C=CCOCC1CO1.CCCN>>C=CCOCC(O)CNCCC,,CCO,,,,val
US04526993,O=CC=Cc1ccccc1.O=Cc1ccccc1>>OCC=CC=Cc1ccccc1,,ClC(Cl)Cl,,,,val
US20070161639A1,CN(C)C(=O)CC1CN(Cc2ccc(F)cc2)C(=O)C2=C(OCc3ccccc3)C(=O)CC=[N+]21.O=C([O-])C(F)(F)F>>CN(C)C(=O)CC1CN(Cc2ccc(F)cc2)C(=O)C2=C(O)C(=O)CC=[N+]21.O=C([O-])C(F)(F)F,[Pd],CO,,,,val
US05424277,COC(=O)Oc1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1Cl>>O=C1C2=C(CCCC2)C(=O)N1c1cc(O)c(Cl)cc1F,,CO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20050267152A1,CSc1cc(F)cc2nc(C)ccc12.O=C(OO)c1cccc(Cl)c1>>Cc1ccc2c(S(C)=O)cc(F)cc2n1,,ClCCl,,,,val
US20150018422A1,CCOC(=O)CC(c1ccnc(CO)c1)C1CC1.COc1ccc(F)c(-c2ccc(O)cc2CC(C)(C)C)c1>>CCOC(=O)CC(c1ccnc(COc2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)c2)c1)C1CC1,,C1CCOC1,Cc1ccccc1,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050043537A1,CCOC(OCC)OCC.CCOc1ccc(N)cc1Br.COc1cc(NC(=O)CC#N)c(Cl)cc1Cl>>CCOc1ccc(NC=C(C#N)C(=O)Nc2cc(OC)c(Cl)cc2Cl)cc1Br,,CC(C)O,,,,val
US05491164,COC(=O)[C@@H]1CCCN1C[C@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)CN1CCC[C@H]1C(=O)O,,CO,,Cl,[Na+].[OH-],val
US05484942,COc1ccccc1CC(=O)O.c1ccc(C2(c3ccccc3)CCSC3CNCC32)cc1>>COc1ccccc1CC(=O)N1CC2SCCC(c3ccccc3)(c3ccccc3)C2C1,,ClCCl,,CCN(CC)CC,Cl,val
US20090247505A1,C1=COCCC1.C[C@@H](CO)CBr>>C[C@H](CBr)COC1CCCCO1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20060030612A1,CON(C)C(=O)c1cccc(C(F)(F)F)c1F.COc1ccc([Mg]Br)cc1>>COc1ccc(C(=O)c2cccc(C(F)(F)F)c2F)cc1,,C1CCOC1,,,,val
US05574178,C=CCc1c(O)cc(C(C)(C)C)c(OC(C)=O)c1C(C)(C)C.CI>>C=CCc1c(OC)cc(C(C)(C)C)c(OC(C)=O)c1C(C)(C)C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090215759A1,CC1(O)CCNCC1.COC(=O)c1cc(Cl)nc(Cl)n1>>COC(=O)c1cc(N2CCC(C)(O)CC2)nc(Cl)n1,,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US04469865,CC(=O)n1ccnc1.CCOC(=O)c1ccc(C=CCBr)cc1>>CCOC(=O)c1ccc(C=CCn2cc[n+](C(C)=O)c2)cc1.[Br-],,CCOCC,,CC#N,,val
US05516788,c1ccc2c(c1)Cc1c-2[nH]c2ccccc12>>c1ccc2c(c1)C[C@@H]1c3ccccc3N[C@H]21,,CC(=O)O,,[Na+].[OH-],,val
US06180627B2,CC1=NC(=O)C(C(=O)O)C=C1.OCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cc1ccc(NC(=O)OCc2ccccc2)c(=O)[nH]1,,C1COCCO1,,CCN(CC)CC,,val
US05998415,CC(C)(C)OC(=O)NCCNCCCc1c[nH]c2ccc(-n3cnnc3)cc12.O=Cc1ccccc1>>CC(C)(C)OC(=O)NCCN(CCCc1c[nH]c2ccc(-n3cnnc3)cc12)Cc1ccccc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20090203737A1,N#C[C@H]1CCCN(C(=O)c2ccc(F)cc2)C1.NO>>N=C(NO)[C@H]1CCCN(C(=O)c2ccc(F)cc2)C1,,CCO,,,,val
US20100323994A1,COc1ccc(CN(c2ccccn2)c2cc(N[C@@H]3CC[C@@H](N)CC3)nn3c(C(=O)Nc4ccnc(F)c4)cnc23)cc1>>N[C@@H]1CC[C@@H](Nc2cc(Nc3ccccn3)c3ncc(C(=O)Nc4ccnc(F)c4)n3n2)CC1,,O=C(O)C(F)(F)F,,CO,O,val
US06057337,CCCCCCCCCCCCCCCCCC(=O)N1CCCCC1CCOC(=O)N1CCN(C)CC1.Cl>>CCCCCCCCCCCCCCCCCC(=O)N1CCCCC1CCOC(=O)N1CCN(C)CC1.Cl,,CCOC(C)=O,,,,val
US07160901B2,CC(=O)N1C(=O)Cc2cc([N+](=O)[O-])ccc21>>CC(=O)N1C(=O)Cc2cc(N)ccc21,[Pd],CO,ClCCl,[H][H],,val
US06255301B1,CCOC(=O)C(CO)c1ccc(OCc2ccccc2)c(OC)c1>>COc1cc(C(CO)C(=O)O)ccc1OCc1ccccc1,,C1CCOC1,O,[Li+].[OH-],,val
US20090227575A1,CN(C)CCn1ccc2c3nc(Cl)nc(N4CCOCC4)c3ccc21.OCc1cccc(B(O)O)c1>>CN(C)CCn1ccc2c3nc(-c4cccc(CO)c4)nc(N4CCOCC4)c3ccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US06559166B1,COC(=O)c1ccc(S(=O)(=O)C2CCN(CCc3ccc(F)cc3F)CC2)cc1>>O=S(=O)(c1ccc(CO)cc1)C1CCN(CCc2ccc(F)cc2F)CC1,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20110003787A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1ccc(Br)[nH]1>>CCOC(=O)c1ccc(Br)n1C(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20080176833A1,CON(C)C(=O)c1n[nH]c2ccc(I)cc12>>O=Cc1n[nH]c2ccc(I)cc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080167348A1,CC(C)(C)OC(=O)n1c(S(=O)(=O)Nc2ccc(-c3ccncc3)cc2)cc2ccccc21.Cl>>Cl.O=S(=O)(Nc1ccc(-c2ccncc2)cc1)c1cc2ccccc2[nH]1,,CCOC(C)=O,CCOCC,,,val
US20150266824A1,CCOC(=O)[C@@H]1CC[C@@H](n2ncc(C(=O)N(Cc3cc(F)cc(F)c3)CC(O)c3c(C)csc3C)c2C(F)(F)F)CC1>>CCOC(=O)[C@@H]1CC[C@@H](n2ncc(C(=O)N(CC(=O)c3c(C)csc3C)Cc3cc(F)cc(F)c3)c2C(F)(F)F)CC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20100003250A1,Nc1nc2cc(-c3nc(N4CCOCC4)c4ccn(CC(F)(F)F)c4n3)ccc2[nH]1.O=C(O)c1ccncc1>>O=C(Nc1nc2cc(-c3nc(N4CCOCC4)c4ccn(CC(F)(F)F)c4n3)ccc2[nH]1)c1ccncc1,,CN(C)C=O,,CCN(CC)CC,,val
US20130225584A1,Nc1ccnnc1.O=C(O)c1cc(Cl)c(C(=O)N2CCC(F)(F)C2)cc1OCc1ccccc1>>O=C(Nc1ccnnc1)c1cc(Cl)c(C(=O)N2CCC(F)(F)C2)cc1OCc1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100130495A1,C=O.CO.Cc1nccn1-c1ccc(Nc2nc3c(c(N4c5ccccc5C[C@H]4CO)n2)CNCC3)cc1>>Cc1nccn1-c1ccc(N(C)c2nc3c(c(N4c5ccccc5C[C@H]4CO)n2)CN(C)CC3)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20140357642A1,Cc1ccc(-c2nc3c(nc2-c2ccc(C)cc2)N(C(=O)OC(C)(C)C)CC(O)C3O)cc1.S=C(n1ccnc1)n1ccnc1>>Cc1ccc(-c2nc3c(nc2-c2ccc(C)cc2)N(C(=O)OC(C)(C)C)CC2OC(=S)OC32)cc1,,C1CCOC1,,,,val
US20110021537A1,COCCOC(=O)Cl.O=C(NCC(=O)N1CCNCC1)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1>>COCCOC(=O)N1CCN(C(=O)CNC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)n(-c3ccccc3)n2)CC1,,ClCCl,,CCN(CC)CC,,val
US20070191340A1,CCBr.Clc1ccccc1-c1ccc(CN2CCN[C@@H](Cc3ccccc3)C2)cc1>>CCN1CCN(Cc2ccc(-c3ccccc3Cl)cc2)C[C@@H]1Cc1ccccc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20060247320A1,CC(C)(C)OC(=O)NCC(NC(=O)c1cc2cc3c(nc2s1)CCC(C(C)(C)C)C3)c1cccc(N)c1.O=C(O)c1ncco1>>CC(C)(C)C1CCc2nc3sc(C(=O)NC(CN)c4cccc(NC(=O)c5ncco5)c4)cc3cc2C1,,CN(C)C=O,O,CN1CCOCC1,,val
US20090093483A1,CC(C)(C)OC(=O)CNC(=O)C1=C(O)c2cc(-c3ccccc3)ccc2C(C)(C)C1=O>>CC1(C)C(=O)C(C(=O)NCC(=O)O)=C(O)c2cc(-c3ccccc3)ccc21,,O=C(O)C(F)(F)F,,,,val
US20040242928A1,CCOC(=O)C(C)=C1CCOCC1>>CC(CO)=C1CCOCC1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150158865A1,CCC(=O)Cl.NC(=O)c1nnc(N2CCC[C@@H](NC(=O)N3CCCCC3)C2)nc1Nc1ccc(C2CCNCC2)cc1>>CCC(=O)N1CCC(c2ccc(Nc3nc(N4CCC[C@@H](NC(=O)N5CCCCC5)C4)nnc3C(N)=O)cc2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20060128712A1,CCN(CC)c1ccc(S(C)(=O)=O)cc1C(=O)O.c1ccc2c(N3CCNCC3)nsc2c1>>CCN(CC)c1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2nsc3ccccc23)CC1,,CC#N,,CCOC(C)=O,Cl,val
US20140371201A1,C=CC(=O)OCC.Nc1ccc(Br)cc1I>>CCOC(=O)/C=C/c1cc(Br)ccc1N,,O,,CN(C)C=O,O=C([O-])O.[Na+],val
US20110212946A1,Cn1c(=O)c(CN(CC(c2ccccc2)C2CCN(C(=O)OC(C)(C)C)CC2)C(=O)C2CCCCC2)cc2ccccc21>>Cn1c(=O)c(CN(CC(c2ccccc2)C2CCNCC2)C(=O)C2CCCCC2)cc2ccccc21,,ClCCl,,C1COCCO1,Cl,val
US04695573,O=C1CCCc2nc3ccccc3c(NCc3ccc(C(F)(F)F)cc3)c21>>OC1CCCc2nc3ccccc3c(NCc3ccc(C(F)(F)F)cc3)c21,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20120208812A1,CC(C)(C)OC(=O)N1CC2CNCC2C1.O=C(O)c1c(F)cccc1-n1nccn1>>CC(C)(C)OC(=O)N1CC2CN(C(=O)c3c(F)cccc3-n3nccn3)CC2C1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040024039A1,O=C(O)c1ccc2cc(Br)ccc2c1.O=S(Cl)Cl>>O=C(Cl)c1ccc2cc(Br)ccc2c1,,C1CCOC1,,CN(C)C=O,,val
US05922770,CN(CCCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N.O=CO>>O=CNCCCc1ccccc1,,O,,CC(=O)OC(C)=O,,val
US20060173050A1,CCOc1nc(C(=O)O)cc(N)c1C#N.NCc1cncs1>>CCOc1nc(C(=O)NCc2cncs2)cc(N)c1C#N,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US05475129,CCOOP(=O)(OOCC)C(F)(F)c1ccc(CC(NC(=O)OC(C)(C)C)C(=O)OC)cc1>>CCOOP(=O)(OOCC)C(F)(F)c1ccc(CC(NC(=O)OC(C)(C)C)C(=O)O)cc1,,C1CCOC1,,[Li+].[OH-],,val
US20070082853A1,CC(C)(C)OC(=O)NOC(Cc1ccccc1)C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NOC(Cc1ccccc1)C(=O)O,,CO,,[Na+].[OH-],,val
US20120214803A1,O=S1(=O)N=Cc2ccc3cccnc3c2N1.[Li]C>>CC1NS(=O)(=O)Nc2c1ccc1cccnc21,,C1CCOC1,,CCOCC,FB(F)F,val
US20040029874A1,CO.O=C(O)c1cc([N+](=O)[O-])ccc1F>>COC(=O)c1cc([N+](=O)[O-])ccc1F,,Cl,,,,val
US20100204234A1,CCOC(=O)/C=C/c1c(OC)ccc2cc(-c3cccc(OC)c3)ccc12>>COc1cccc(-c2ccc3c(/C=C/C(=O)O)c(OC)ccc3c2)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20040110804A1,CO.CON(Cc1ccccc1C)C(=O)C=C1OC(C)(C)OC1=O>>COC(=O)C(O)=CC(=O)N(Cc1ccccc1C)OC,,CO,,,,val
US20110311466A1,O=C(Nc1ccccn1)N1CCC(c2ccc(OCc3ccccc3)cc2OCc2ccccc2)CC1>>O=C(Nc1ccccn1)N1CCC(c2ccc(O)cc2O)CC1,[Pd],CCOC(C)=O,,CO,,val
US20160083400A1,CCOC(C)=O.CO.Cn1cc(C(F)(F)F)nc1C1CCOCC1>>COC(=O)c1c[nH]c(C2CCOCC2)n1,,CO,,Cl,[Na+].[OH-],val
US20110256550A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCCCOc1cc(Br)cc(Br)c1>>CC(C)(C)OC(=O)NCCCCOc1cc(Br)cc(Br)c1,,C1CCOC1,,,,val
US05232922,C1CSCCN1.Cn1cnc(S(=O)(=O)Cl)c1>>Cn1cnc(S(=O)(=O)N2CCSCC2)c1,,CC#N,,,,val
US20160002225A1,COc1ccc(Cn2nc(N[C@@H]3CCN(C(=O)OC(C)(C)C)C3)c3c(Oc4cccc(C(=O)Nc5ccc(C(C)C)c(C)c5)c4)ccnc32)cc1>>COc1ccc(Cn2nc(N[C@@H]3CCNC3)c3c(Oc4cccc(C(=O)Nc5ccc(C(C)C)c(C)c5)c4)ccnc32)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20070203192A1,COc1cccc2c1CCC(CN(C)C)C2=O>>COc1cccc2c1CCC(CN(C)C)C2=O,,O,,Cl,[Na+].[OH-],val
US05362736,CCN=C=NCCCN(C)C.COc1ccc(CC2NCCc3cc(OC)c(OC)c(O)c32)cc1.On1nnc2ccccc21>>COc1ccc(CC2c3c(cc(OC)c(OC)c3O)CCN2C(=O)CN(C)C)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20140045862A1,CC(=O)OC(C)=O.Cn1nccc1[C@H]1C[C@H](O)CC[C@@H]1Oc1cc(F)c(S(=O)(=O)Nc2ccncn2)cc1Cl>>CC(=O)O[C@@H]1CC[C@H](Oc2cc(F)c(S(=O)(=O)Nc3ccncn3)cc2Cl)[C@@H](c2ccnn2C)C1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20060211724A1,CCOCCC(=O)O.O=C1c2c(c(O)c3nccnc3c2O)C(=O)N1Cc1ccc2c(c1)OCO2>>CCOCCC(=O)Oc1c2c(c(O)c3nccnc13)C(=O)N(Cc1ccc3c(c1)OCO3)C2=O,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20040048868A1,CCOc1cc(C(=O)OC)n(Cc2ccccc2)n1>>CCOc1cc(CO)n(Cc2ccccc2)n1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05246810,CCc1cccc(CC)c1NC(=N)Nc1c(CC)cccc1CC.Cc1cccc(C(Cl)Cl)c1>>CCc1cccc(CC)c1NC(=NCc1cccc(CCl)c1)Nc1c(CC)cccc1CC,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20090131413A1,O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1.OCCN1CCNCC1>>O=[N+]([O-])c1ccc(S(=O)(=O)N2CCN(CCO)CC2)cc1,,ClCCl,,CCN(CC)CC,,val
US20090186895A1,CC(=O)Cl.Cn1ncc(Cl)c1-c1cc(NC(=O)c2cccc(C(F)(F)F)c2)ccc1OCC(C)(C)[N+](=O)[O-]>>CCNC(C)(C)COc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1c(Cl)cnn1C,[Zn],CO,,,,val
US05580866,CS(=O)(=O)Cl.Cc1cccc2c1CNCCS2>>Cc1cccc2c1CN(S(C)(=O)=O)CCS2,,ClCCl,,CCN(CC)CC,Cl,val
US04294839,CCOC(=O)C(C)(Sc1nc2ccc(O)cc2s1)c1ccccc1.CCOS(=O)(=O)OCC>>CCOC(=O)C(C)(Sc1nc2ccc(OCC)cc2s1)c1ccccc1,,[Na+],[OH-],,,val
US04719312,CCCCCCCCCCCCNC(=O)C(F)(F)F>>CCCCCCCCCCCCNCC(F)(F)F,,C1CCOC1,,Cl,,val
US20070032530A1,COC(=O)c1cncc(-c2ccc(Cl)cc2)c1>>OCc1cncc(-c2ccc(Cl)cc2)c1,,CCO,,[BH4-].[Na+],,val
US20120058984A1,COc1ccc2nc(Nc3cc(C(F)(F)c4ccc(F)cc4)nc(Cl)n3)sc2c1.Nc1ccc(CC(=O)O)cc1>>COc1ccc2nc(Nc3cc(C(F)(F)c4ccc(F)cc4)nc(Nc4ccc(CC(=O)O)cc4)n3)sc2c1,Cl,CS(C)=O,,,,val
US20110319378A1,CC1(C)OCC(C[C@@]2(C)C[C@H](c3cccc(Cl)c3)[C@@H](c3ccc(Cl)cc3)N(C3C=CCC3)C2=O)O1>>C[C@]1(CC(O)CO)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N(C2C=CCC2)C1=O,,C1CCOC1,CCOC(C)=O,Cl,,val
US20150299183A1,CNC(=O)c1nnc(Nc2ccccn2)cc1Nc1cccc(C(=O)O)c1SC.N>>CNC(=O)c1nnc(Nc2ccccn2)cc1Nc1cccc(C(N)=O)c1SC,,CN(C)C=O,O,ClCCCl,On1nnc2ccccc21,val
US20090099207A1,CC(C)(C)c1cccc(C2(N[C@H]3CS(=O)(=O)C[C@@H](Cc4ccc(N=[N+]=[N-])cc4)[C@@H]3O)CC2)c1>>CC(C)(C)c1cccc(C2(N[C@H]3CS(=O)(=O)C[C@@H](Cc4ccc(N)cc4)[C@@H]3O)CC2)c1,[Pd],CO,,,,val
US20120034270A1,CC(C)(C)OC(=O)NC1(CN2CCc3cc(OCc4ccccc4)ccc3C2)COC(C)(C)OC1>>CC(C)(C)OC(=O)NC1(CN2CCc3cc(O)ccc3C2)COC(C)(C)OC1,[Pd],CCOC(C)=O,,,,val
US04873236,NCCN1CCC(CN2CCCCC2)C1.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>O=C1Nc2cccnc2N(C(=O)NCCN2CCC(CN3CCCCC3)C2)c2ccccc21,,CC#N,,,,val
US20110112133A1,Cc1ccn(-c2ccc(C(=O)N[C@@H]3CCC(F)(F)C[C@@H]3C(=O)N3CCc4c(-c5ncc[nH]5)nc5ccc(F)cc5c43)cc2)n1.Cl>>Cc1ccn(-c2ccc(C(=O)N[C@@H]3CCC(F)(F)C[C@@H]3C(=O)N3CCc4c(-c5ncc[nH]5)nc5ccc(F)cc5c43)cc2)n1.Cl,,CO,,,,val
US20030125317A1,C1COCCO1.CCO.Nc1ccnc(NCCCOc2ccc3c(c2)CNC(=O)C(CC(=O)O)C3)c1>>CCOC(=O)CC1Cc2ccc(OCCCNc3ccccn3)cc2CN(C)C1=O,,CCO,,CCN(CC)CC,Cl,val
US20080207645A1,CC1(C)Cc2c(c(N3CCCC3)nc3sc4c(Cl)ncnc4c23)CO1.COc1cccc(CN)c1OC>>COc1cccc(CNc2ncnc3c2sc2nc(N4CCCC4)c4c(c23)CC(C)(C)OC4)c1OC,,CCO,,,,val
US20110039843A1,FC(F)(F)c1c[nH]cn1.Fc1cnccc1-c1nc2cc(C(F)(F)F)ccc2o1>>FC(F)(F)c1ccc2oc(-c3ccncc3-n3cnc(C(F)(F)F)c3)nc2c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100317568A1,O=C(CCC(=O)c1ccc([N+](=O)[O-])cc1)c1ccc(Br)cc1>>O=[N+]([O-])c1ccc(C(O)CCC(O)c2ccc(Br)cc2)cc1,,CCO,,[BH4-].[Na+],,val
US05006522,O=C1Nc2cccnc2N(CC#CCN2CCCCC2)c2ccccc21>>O=C1Nc2cccnc2N(CCCCN2CCCCC2)c2ccccc21,,CCOC(C)=O,,,,val
US20050119320A1,CC(=O)Nc1nc(C)c(-c2ccc(C(=O)O)cc2)s1.NCCO>>CC(=O)Nc1nc(C)c(-c2ccc(C(=O)NCCO)cc2)s1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120197027A1,COc1cc2c(=O)n(COC(=O)C(C)(C)C)cnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1.Cl>>COc1cc2c(=O)n(COC(=O)C(C)(C)C)cnc2cc1OCC1CCNCC1.Cl,,CC(C)O,ClCCl,CCOCC,,val
US04372953,O=C(Cl)CCCCl.c1ccc2ccccc2c1>>O=C(CCCCl)c1ccc2ccccc2c1,,O=[N+]([O-])c1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20040152740A1,Cc1ccccc1NC(=O)C(C)NC(=O)OC(C)(C)C.O=CO>>Cc1ccccc1NC(=O)C(C)N.O=CO,,O=CO,,,,val
US05346920,CCOC(=O)NCCCl.Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1Cl>>CCOC(=O)NCCOc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050182088A1,COC(=O)c1cccc(Cl)c1Cl.O=[N+]([O-])O>>COC(=O)c1c([N+](=O)[O-])ccc(Cl)c1Cl,,O=S(=O)(O)O,,O,,val
US20120053216A1,BrC(Br)(Br)Br.OCc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1>>FC(F)(F)Oc1ccc(-n2cnc(-c3ccc(CBr)cc3)n2)cc1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150252059A1,CC#CCO.Oc1cnc2c(Cl)ncc(F)c2c1>>CC#CCOc1cnc2c(Cl)ncc(F)c2c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110201501A1,O=C(O)c1ncccc1O.Oc1c(F)c(F)c(F)c(F)c1F>>O=C(Oc1c(F)c(F)c(F)c(F)c1F)c1ncccc1O,,ClCCl,O,CC(C)N=C=NC(C)C,,val
US20100222398A1,COc1ccc(CC#N)cc1.[N-]=[N+]=Nc1ccc(F)cc1Cl>>COc1ccc(-c2nnn(-c3ccc(F)cc3Cl)c2N)cc1,,CCO,CCOC(C)=O,C[O-].[Na+],,val
US20120322785A1,C#C[Si](C)(C)C.Fc1ccc(Cl)c(I)c1>>C[Si](C)(C)C#Cc1cc(F)ccc1Cl,[Cu]I,C1COCCO1,CCOCC,CCN(C(C)C)C(C)C,,val
US20090143358A1,CCOC(=O)c1ccc(S(=O)(=O)Cl)c(F)c1.COc1ccc(CNc2nccs2)c(OC)c1>>CCOC(=O)c1ccc(S(=O)(=O)N(Cc2ccc(OC)cc2OC)c2nccs2)c(F)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20070249642A1,C[Si](C)(C)Oc1ncc(F)c(O[Si](C)(C)C)n1.ClCCCBr>>O=c1[nH]c(=O)n(CCCCl)cc1F,,ClCCCl,,O,[Na+].[OH-],val
US20040247639A1,CC(C)(C)OC(=O)N[C@@H](CCC(=O)OC1CCCCC1)CSc1ccc(Cc2ccccc2)cc1>>N[C@@H](CCC(=O)OC1CCCCC1)CSc1ccc(Cc2ccccc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06372726B1,C=C(CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1.O=[PH](O)Cc1ccccc1>>O=C(CCC(CP(=O)(O)Cc1ccccc1)C(=O)OCc1ccccc1)OCc1ccccc1,,ClCCl,,CCN(CC)CC,C[Si](C)(C)Cl,val
US05614498,CC(C)C[C@H](N)C(=O)OCc1ccccc1.O=C(Cl)Oc1ccccc1>>CC(C)C[C@H](NC(=O)Oc1ccccc1)C(=O)OCc1ccccc1,,c1ccncc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150232481A1,C=Cc1cc(F)ccc1Br.CN(C)C=O>>C=Cc1cc(F)ccc1C=O,,C1CCOC1,,[Li]CCCC,,val
US20010021718A1,C1CCNC1.CCOC(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1>>CC(C)(C)OC(=O)C[C@@H](CCCC1CCCCC1)c1nc(C(=O)N2CCCC2)no1,,CCO,,,,val
US20130184479A1,COc1c(C(C)(C)C)cc(P(Cl)c2cc(C(C)(C)C)c(OC)c(C(C)(C)C)c2)cc1C(C)(C)C.COc1cc(Br)cc(OC)c1.OO>>COc1cc(OC)cc(P(=O)(c2cc(C(C)(C)C)c(OC)c(C(C)(C)C)c2)c2cc(C(C)(C)C)c(OC)c(C(C)(C)C)c2)c1,II,C1CCOC1,O,[Mg],,val
US20040229937A1,O=C(Nc1ccc(Oc2ccncc2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1.O=C(OO)c1cccc(Cl)c1>>O=C(Nc1ccc(Oc2cc[n+]([O-])cc2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1,,CC(C)=O,ClCCl,,,val
US04014883,COS(=O)(=O)OC.Clc1ccc2nc(Cl)c3[nH]c4ccccc4c3c2c1>>Cn1c2ccccc2c2c3cc(Cl)ccc3nc(Cl)c21,,C1CCOC1,,[H-].[Na+],,val
US20160009666A1,Nc1nc(Nc2cc(Cl)cc(Cl)c2)n[nH]1.O=Cc1cc(Cl)ccc1C(F)(F)F>>FC(F)(F)c1ccc(Cl)cc1CNc1nc(Nc2cc(Cl)cc(Cl)c2)n[nH]1,,CO,,[BH4-].[Na+],,val
US20110288065A1,C[C@H](Nc1nc(Cl)cc(Cl)n1)c1ccc(F)cc1.O=C1CCCN1>>C[C@H](Nc1nc(Cl)cc(N2CCCC2=O)n1)c1ccc(F)cc1,,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20130225578A1,CSc1nc(C(F)(F)c2ccc(F)cc2)nc2cc(Br)ccc12.OB(O)c1cncnc1>>CSc1nc(C(F)(F)c2ccc(F)cc2)nc2cc(-c3cncnc3)ccc12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20100048610A1,C=CB(O)O.CCOC(=O)c1cnc(O)c(I)c1>>C=Cc1cc(C(=O)OCC)cnc1O,,O,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20140088078A1,CC(C)(C)OC(=O)N1CCC[C@H]1COO.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1,,c1ccncc1,,,,val
US20100298288A1,CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NC[C@H]4CCCNC4)cc3)oc12.FC(F)(F)c1cccc(CBr)c1>>CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NC[C@H]4CCCN(Cc5cccc(C(F)(F)F)c5)C4)cc3)oc12,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150191427A1,CC(=O)Nc1ccc(C(=O)Nc2ccc(F)cc2NC(=O)OC(C)(C)C)cc1>>CC(=O)Nc1ccc(C(=O)Nc2ccc(F)cc2N)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030199550A1,CN(C[C@@H]1CC[C@@H](OCCCCOCc2ccccc2)CC1)C(=O)OC(C)(C)C>>CN(C[C@@H]1CC[C@@H](OCCCCO)CC1)C(=O)OC(C)(C)C,[Pd],CO,,,,val
US20140107340A1,COC(=O)C1=C(O)CCC(C#N)(c2ccc(F)nc2)C1>>N#CC1(c2ccc(F)nc2)CCC(=O)CC1,,CS(C)=O,,O,[Cl-].[Na+],val
US07518000B2,CC(=O)n1ncc2sc(-c3ccccc3)cc21.CCO.COC(=O)c1cc2c(cnn2C(C)=O)s1.Cc1ccc(C(=O)O)s1>>CC(=O)n1ncc2sc(-c3ccccc3)cc21.c1ccc(-c2cc3[nH]ncc3s2)cc1,,CCO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20100331326A1,COc1cncc(Br)c1.O=C1NCCN1c1ccc2ccccc2c1>>COc1cncc(N2CCN(c3ccc4ccccc4c3)C2=O)c1,I[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=C([O-])[O-].[K+].[K+],val
US06265423B1,O=Cc1cc(Br)cs1.[Li]C>>CC(O)c1cc(Br)cs1,,CCOCC,CCOCC,O,[Cl-].[NH4+],val
US06875884B1,O=C1c2ccccc2C(=O)N1CCCN(CCCc1nnnn1C(c1ccccc1)(c1ccccc1)c1ccccc1)C1CCCc2ccccc21.O=C=Nc1ccc(Br)cc1>>O=C(NCCCN(CCCc1nnnn1C(c1ccccc1)(c1ccccc1)c1ccccc1)C1CCCc2ccccc21)Nc1ccc(Br)cc1,,CCO,,NN,O,val
US20050038038A1,CC(C)=O.NCc1ccccc1[N+](=O)[O-]>>CC(C)NCc1ccccc1[N+](=O)[O-],,CO,,Cl,[BH3-]C#N.[Na+],val
US20060205718A1,CCOc1cc(CO)ccc1Cl>>CCOc1cccc(C=O)c1Cl,O=[Mn]=O,,,ClCCl,,val
US20110312945A1,CCOC(=O)Cn1c(C)c(Sc2ccccc2)c2c1CCC(C)(C)C2.O=S(=O)(O)Cl>>CCOC(=O)Cn1c(C)c(Sc2ccc(S(=O)(=O)Cl)cc2)c2c1CCC(C)(C)C2,,ClCCl,,CCOC(C)=O,,val
US20120015936A1,CI.N#CC1CCOCC1>>CC1(CN)CCOCC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100190831A1,CCOC(=O)/C=C/c1ccc(O)cc1-c1ccccc1>>CCOC(=O)CCc1ccc(O)cc1-c1ccccc1,[Pd],CCO,,[H][H],,val
US20150196672A1,COC(=O)c1ccc(OCCCF)nc1>>OCc1ccc(OCCCF)nc1,,C1CCOC1,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130029987A1,O=C1c2ccccc2C(=O)N1[C@@H]1CCCC[C@H](O)[C@H]1Br>>O=C1c2ccccc2C(=O)N1[C@@H]1CCCC[C@H](O)C1,,CO,Cc1ccccc1,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US04841077,COc1ccc(-c2c(C)oc3cc(OC(C)=O)cc(OC(C)=O)c3c2=O)cc1.O=C1CCC(=O)N1Br>>COc1ccc(-c2c(CBr)oc3cc(OC(C)=O)cc(OC(C)=O)c3c2=O)cc1,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20020052512A1,CC(C)(C)[Si](C)(C)Oc1cccc(CNC(=O)c2cc(Cl)c(O)c(Cl)c2)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)[Si](C)(C)Oc1cccc(CNC(=O)c2cc(Cl)c(OS(=O)(=O)C(F)(F)F)c(Cl)c2)c1,,ClCCl,,CCN(CC)CC,,val
US06350892B1,CCCCCCCCCCCCN(C)CCOc1ccc(CCC(=O)OC)c(O)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCCCCCCCCCCCN(C)CCOc1ccc(CCC(=O)OC)c(OS(=O)(=O)C(F)(F)F)c1,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US20120059002A1,COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(OCCN)c(C)c3)nc2c1.Clc1ncccn1>>COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(OCCNc4ncccn4)c(C)c3)nc2c1,,CC(C)(C)O,,CCN(CC)CC,,val
US20030162795A1,CC(C)=O.Cn1cncc1-c1cc2nccc(Cl)c2s1>>Cn1c(-c2cc3nccc(Cl)c3s2)cnc1C(C)(C)O,,C1CCOC1,O,[Li]CCCC,,val
US20100069381A1,COCn1ncc2cc(-c3nnc(S)o3)ccc21.FC(F)(F)c1cccc(CCl)c1>>COCn1ncc2cc(-c3nnc(SCc4cccc(C(F)(F)F)c4)o3)ccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20140303139A1,C[C@H](Nc1cc(C(N)=O)nc(-c2ccnc(F)c2)n1)C(N)=O.Oc1ccc(F)cc1>>C[C@H](Nc1cc(C(N)=O)nc(-c2ccnc(Oc3ccc(F)cc3)c2)n1)C(N)=O,,CN(C)C=O,,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],val
US05880135,CCCN(c1ccc2[nH]ccc2c1)c1nc(-c2ccc(OC)cc2Cl)c(C)s1.CI>>CCCN(c1ccc2c(ccn2C)c1)c1nc(-c2ccc(OC)cc2Cl)c(C)s1,,CN(C)C=O,,[H-].[Na+],,val
US20080269244A1,Cc1nc(Cl)ccc1[N+](=O)[O-].O=C(c1c(F)cccc1F)N1CCNCC1>>Cc1nc(N2CCN(C(=O)c3c(F)cccc3F)CC2)ccc1[N+](=O)[O-],,O,,CCN(CC)CC,CO,val
US20140080825A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1csc(N)n1>>CCOC(=O)c1csc(NC(=O)OC(C)(C)C)n1,CN(C)c1ccncc1,ClCCl,O,,,val
US20040092559A1,COC(=O)[C@@H]1[C@@H](O)CCN1C(=O)OC(C)(C)C.O=C(O)c1ccccc1>>COC(=O)[C@@H]1[C@H](OC(=O)c2ccccc2)CCN1C(=O)OC(C)(C)C,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06479424B1,CC(C)(C)c1ccc(CCC(=O)Cl)cc1>>CC(C)(C)c1ccc2c(c1)C(=O)CC2,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130281564A1,COC(=O)C=Cc1ccc(O)cc1.OCCCCCCCl>>COC(=O)/C=C/c1ccc(OCCCCCCO)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090239845A1,CC(=O)c1ccc(C(=O)Nc2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1.CC(C)CN.ClCCl>>Cc1cc(NC(=O)c2ccccc2C(C)NCC(C)C)nn1Cc1cc(Cl)ccc1OCC(C)C.Cl,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20050049290A1,CC(C)CN(CC(C)C)C(=O)c1ccc(NCCCN(C)CCc2ccncc2)c([N+](=O)[O-])c1>>CC(C)CN(Cc1ccc(NCCCN(C)CCc2ccncc2)c(N)c1)CC(C)C,,C1CCOC1,,CCOC(C)=O,Cl,val
US20090054508A1,O=C(Nc1ccccc1/C=C/c1n[nH]c2ccccc12)c1ccc([N+](=O)[O-])s1>>Nc1ccc(C(=O)Nc2ccccc2/C=C/c2n[nH]c3ccccc23)s1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20040006081A1,BrC(Br)(Br)Br.OCCC(c1ccccc1)c1ccc(F)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCC(C)C.Fc1ccc(C(CCBr)c2ccccc2)cc1,,ClCCl,,,,val
US20090035215A1,CC(C)C[Si](CCCCC(=O)ON1C(=O)CCC1=O)(CC(C)C)OCCCCc1ccccc1.Nc1ccccc1>>CC(C)C[Si](CCCCC(=O)Nc1ccccc1)(CC(C)C)OCCCCc1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20080261978A1,CCN(CC)CCOc1ccc(NS(=O)(=O)c2ccc(C#N)cc2)cc1>>CCN(CC)CCOc1ccc(NS(=O)(=O)c2ccc(CN)cc2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060241127A1,O=[N+]([O-])c1ccc(Oc2ccc3[nH]ncc3c2)c(F)c1>>Nc1ccc(Oc2ccc3[nH]ncc3c2)c(F)c1,O=[Pt]=O,CCO,,,,val
US05026874,C#CCCCCC12OCC(CCC)(CS1)CS2.O=C(OO)c1cccc(Cl)c1>>C#CCCCCC12OCC(CCC)(CS1)CS2=O,,CC#N,,O,CC(=O)[O-].[Na+],val
US05604213,CCB(CC)c1cccnc1.C[C@]12CCC(Oc3c(F)c(F)c(C(F)(F)F)c(F)c3F)=CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(OS(=O)(=O)C(F)(F)F)=CC[C@@H]12>>C[C@]12CCC(Oc3c(F)c(F)c(C(F)(F)F)c(F)c3F)=CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20150191461A1,CC(C)(C)OC(=O)NCCn1cc(Cl)cn1.Cc1cc(Nc2nccc(C(F)F)n2)cc(B2OC(C)(C)C(C)(C)O2)c1>>Cc1cc(Nc2nccc(C(F)F)n2)cc(-c2cnn(CCN)c2)c1.Cl,,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20060100262A1,COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(CO)COc1ccccc1-3>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(C=O)COc1ccccc1-3,,CCOC(C)=O,ClCCl,,,val
US20040242572A1,COC(=O)c1cc(-c2ccc(Cl)cc2)cs1>>O=C(O)c1cc(-c2ccc(Cl)cc2)cs1,,CCO,,[Na+].[OH-],,val
US20040110807A1,CCOC(=O)C(Cc1ccc(O)c2ccccc12)OCC.Cc1sc(-c2ccccc2)nc1CCO>>CCOC(=O)C(Cc1ccc(OCCc2nc(-c3ccccc3)sc2C)c2ccccc12)OCC,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100137338A1,COC(=O)c1ccc(-c2ccnn2C)c(Br)c1>>Cn1nccc1-c1ccc(C(=O)O)cc1Br,,CO,,[Na+].[OH-],,val
US20150353559A1,CC(C)(C)OC(=O)N1C[C@@H]2CN(C(=O)OCc3cc(Cl)cc(Cl)c3)C[C@@H]2C1.Cl>>Cl.O=C(OCc1cc(Cl)cc(Cl)c1)N1C[C@@H]2CNC[C@@H]2C1,,CC(C)O,,,,val
US05068413,N#CC1(C(C(=O)O)C(=O)O)CCCCC1>>N#CC1(CC(=O)O)CCCCC1,,Cc1ccccc1,,,,val
US20090004209A1,NC1CCC(=O)NC1=O.O=C(O)c1cccc(OCc2sc3ccccc3c2Cl)c1C(=O)O>>O=C1CCC(N2C(=O)c3cccc(OCc4sc5ccccc5c4Cl)c3C2=O)C(=O)N1,,c1ccncc1,,Cl,,val
US20100016279A1,CC(C)(C)OC(=O)N1CC2CN(c3ccc4nnc(C(F)(F)F)n4n3)CC2C1>>FC(F)(F)c1nnc2ccc(N3CC4CNCC4C3)nn12,,ClCCl,,O=C(O)C(F)(F)F,,val
US05254595,Clc1ccccc1OCC1CO1.NC1CCc2ccccc2C1>>OC(CNC1CCc2ccccc2C1)COc1ccccc1Cl,,CCO,,,,val
US20160257657A1,COC(=O)CBr.Sc1ccccc1>>COC(=O)CSc1ccccc1,,C1CCOC1,CCOCC,CCN(CC)CC,O=C([O-])O.[Na+],val
US20160039865A1,C1CNCCN1.C[C@]12CC[C@@H](N)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccc(=O)oc3)CC[C@]12O.O=C(n1ccnc1)n1ccnc1>>C[C@]12CC[C@@H](NC(=O)N3CCNCC3)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccc(=O)oc3)CC[C@]12O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150079519A1,COC(CCCNC(=O)C(=Cc1ccc(N=[N+]=[N-])cc1)NC(=O)c1ccc(CN2CCOCC2)cc1)OC>>[N-]=[N+]=Nc1ccc(C=C(NC(=O)c2ccc(CN3CCOCC3)cc2)C(=O)NCCCC=O)cc1,,O,,O=P(O)(O)O,,val
US20090253750A1,CC(=O)Cl.N#CCC(N)=S>>CC(=O)C(C#N)C(N)=S,,c1ccncc1,,Cl,O,val
US20060035910A1,CCOC(=O)CC(=O)c1ccncc1.NC1=NCCC(C(F)(F)F)N1>>O=c1cc(-c2ccncc2)nc2n1CCC(C(F)(F)F)N2,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20020013325A1,CC(=O)O.CC(C)(C)OC(=O)CN1C(=O)CC2(CCN(CCc3ccncc3)CC2)CC1=O.O=[Pt]=O>>CC(=O)O.CC(=O)O.O=C(O)CN1C(=O)CC2(CCN(CCC3CCNCC3)CC2)CC1=O,O=[Pt]=O,CC(=O)O,,,,val
US20060155128A1,COc1c(Nc2ccc(CC(=O)O)nc2C)ncnc1OC1CCN(C(=O)OC(C)C)CC1>>COc1c(Nc2ccc(CCO)nc2C)ncnc1OC1CCN(C(=O)OC(C)C)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070037794A1,CC(C)(C)[Si](C)(C)OCC=O.Cc1ccc(S(=O)(=O)Nc2cc(Cl)cnc2C(=O)c2ccnc(N)c2)cc1C(F)(F)F>>Cc1ccc(S(=O)(=O)Nc2cc(Cl)cnc2C(O)c2ccnc(NCCO[Si](C)(C)C(C)(C)C)c2)cc1C(F)(F)F,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040192767A1,COC(=O)c1cc(CSc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c(C)o1.FC(F)Oc1ccc(I)cc1>>COC(=O)c1cc(CSc2ccc(-c3ccc(OC(F)F)cc3)cc2)c(C)o1,,C1COCCO1,,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],val
US20100041892A1,CCOC(=O)CP(=O)(OCC)OCC.O=Cc1cc(-c2ccccc2)nn1Cc1ccc(Cl)cc1Cl>>CCOC(=O)/C=C/c1cc(-c2ccccc2)nn1Cc1ccc(Cl)cc1Cl,,C1CCOC1,CN(C)C=O,[H-].[Na+],[Cl-].[NH4+],val
US04026936,Nc1ccc(C(=O)c2ccccn2)cc1[N+](=O)[O-]>>Nc1ccc(C(=O)c2ccccn2)cc1N,[Pd],C1CCOC1,,[H][H],,val
US20070082923A1,CCCCCCCCCCCCSC(=Cc1ccc(Cl)cc1)CO.CO>>O=C(CO)Cc1ccc(Cl)cc1,,CCCCCCC,,O=S(=O)(O)O,,val
US20110086854A1,CC(C)(C)CC1CNC(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.N#Cc1ccc(C(=O)O)cc1>>CC(C)(C)CC1CN(C(=O)c2ccc(C#N)cc2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020103229A1,O=C(CC1CCCCC1)Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1>>O=C(CC1CCCCC1)Nc1cccc(-c2n[nH]c3ccc(-c4nc[nH]n4)cc23)c1,,C1COCCO1,Cl,,,val
US20020091148A1,CN(NC(=O)OCc1ccccc1)C(=O)OC(C)(C)C>>CNNC(=O)OCc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080125434A1,NC1=NC(=O)c2ccccc21.O=C(NCCC1CC1)c1ccc(N2CCNCC2)nn1>>O=C(NCCC1CC1)c1ccc(N2CCN(C3=NC(=O)c4ccccc43)CC2)nn1,,CCO,,,,val
US20060148858A1,CC(C)c1nn(-c2ncc(C#N)cn2)cc1CCCO.COC(=O)Cc1cccc(OC)c1O>>COc1cccc(CC(=O)O)c1OCCCc1cn(-c2ncc(C#N)cn2)nc1C(C)C,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20070149533A1,CC1CN=C(c2cc(Oc3ccc4ncc(C(=O)Nc5cc(OCCN6CCCC6)cc(C(F)(F)F)c5)cc4c3)ccn2)N1>>Cc1cnc(-c2cc(Oc3ccc4ncc(C(=O)Nc5cc(OCCN6CCCC6)cc(C(F)(F)F)c5)cc4c3)ccn2)[nH]1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20150166480A1,COC(=O)c1ccc(-c2cnc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cn2)c(F)c1>>O=C(O)c1ccc(-c2cnc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cn2)c(F)c1,,C1CCOC1,,O,[Li]O,val
US20020169157A1,CC(C)(C)OC(=O)NCCCCO.CCOC(=O)N=NC(=O)OCC.O=C([O-])c1c(O)cccc1O>>COC(=O)c1c(O)cccc1OCCCCNC(=O)OC(C)(C)C,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130203768A1,CS(=O)(=O)Cl.Cc1cc(N2CCNCC2)c2ccccc2n1>>Cc1cc(N2CCN(S(C)(=O)=O)CC2)c2ccccc2n1,,ClCCl,,CCN(CC)CC,,val
US20020058832A1,CC(C)(C)OC(=O)C/C(=C\CCc1ccccc1)C(=O)O.NC1CCCCC1>>CC(C)(C)OC(=O)C[C@@H](CCCc1ccccc1)C(=O)O.NC1CCCCC1,,CO,,,,val
US20030034722A1,BrCc1ccccc1.CCOC(=O)CNCC(=O)OCC>>CCOC(=O)CN(CC(=O)OCC)Cc1ccccc1,,O,,CN(C)C=O,O=C([O-])O.[Na+],val
US20050032786A1,CCN1CCN(c2ccncc2)C1=O.O=C(OO)c1cccc(Cl)c1>>CC[N+]1([O-])CCN(c2ccncc2)C1=O,,CCOC(C)=O,,,,val
US20100113391A1,CCOC(=O)CNCCn1c(=O)c2cc(F)c(NC3CCCCC3)cc2n(C2CCCC2)c1=O.COC(=O)Cl>>CCOC(=O)CN(CCn1c(=O)c2cc(F)c(NC3CCCCC3)cc2n(C2CCCC2)c1=O)C(=O)OC,,O,,CCN(CC)CC,ClCCl,val
US20130225588A1,COC(=O)Cc1cc2ccc(Cl)cc2c(-c2ccc(S(=O)(=O)c3ccccc3OC(F)(F)F)cc2)c1C>>Cc1c(CC(=O)O)cc2ccc(Cl)cc2c1-c1ccc(S(=O)(=O)c2ccccc2OC(F)(F)F)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US04460584,Cc1ncc[nH]1.OCCCCl>>Cc1nccn1CCCO,,CN(C)C=O,,[H-].[Na+],,val
US20080166359A1,O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC2(C1)OC2CC1OCCO1.[N-]=[N+]=[N-]>>[N-]=[N+]=NC(CC1OCCO1)C1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1,,CN(C)C=O,,CCOC(C)=O,,val
US20150001472A1,CC(C)Cc1cccc2[nH]c(=O)ccc12.O=P(Cl)(Cl)Cl>>CC(C)Cc1cccc2nc(Cl)ccc12,,CN(C)C=O,,,,val
US20100305092A1,CCOC(=O)CC(=O)C(C)C.[N-]=[N+]=Nc1ccccc1F>>CCOC(=O)c1nnn(-c2ccccc2F)c1C(C)C,,CN(C)C=O,,C1CCC2=NCCCN2CC1,O,val
US20060079519A1,COC(=O)c1ccc(C)c(N)c1.Cc1c(C(=O)CBr)cnn1-c1ccccc1>>COC(=O)c1ccc(C)c(NCC(=O)c2cnn(-c3ccccc3)c2C)c1,,CCO,,,,val
US05659059,CCCCCC1CC[SiH](OC)CC1.CCCc1ccc(-c2ccc(Br)cc2F)c(F)c1>>CCCCC[C@@H]1CC[Si@@H](c2ccc(-c3ccc(CCC)cc3F)c(F)c2)CC1,,C1CCOC1,,[Mg],,val
US20110275611A1,COc1ccc(-c2c[nH]c(C3CN(Cc4ccccc4)CCO3)n2)cc1.Cl>>COc1ccc(-c2c[nH]c(C3CNCCO3)n2)cc1.Cl,[Pd],CO,,,,val
US20150376181A1,CC1(C2CCCC2)NC(=O)c2ccc(Nc3cc(N)ncn3)c(=O)n21.N#CBr>>CC1(C2CCCC2)N(C#N)C(=O)c2ccc(Nc3cc(N)ncn3)c(=O)n21,,C1CCOC1,,[H-].[Na+],,val
US20100029589A1,CCOC(=O)[C@@H](N)CCC(C)(C)c1ccccc1>>CC(C)(CC[C@H](N)CO)c1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US05719141,COc1ccc([N+](=O)[O-])c(OCC(N)=O)c1>>COc1ccc(N)c(OCC(N)=O)c1,[Ni],CO,,,,val
US05521179,CC(C)C(NC(=O)Cn1cccc(N)c1=O)C(=O)C(F)(F)F.O=C(Cl)CCc1ccccc1>>CC(C)C(NC(=O)Cn1cccc(NC(=O)CCc2ccccc2)c1=O)C(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20140050743A1,CC=CI.O=C(NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2F)C(=O)O1)c1ccc(Cl)s1>>C=CCC1OCCN(c2ccc(N3C[C@H](CNC(=O)c4ccc(Cl)s4)OC3=O)c(F)c2)C1=O,,C1CCOC1,CCOC(C)=O,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20110009432A1,COc1ccc([C@@H](O)COS(=O)(=O)c2ccc(C)cc2)cn1>>COc1ccc([C@@H]2CO2)cn1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20160016936A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)C(F)C1.Cc1cc(C(=O)CBr)ccc1F>>Cc1cc(C(=O)COC(=O)C2CCN(C(=O)OC(C)(C)C)CC2F)ccc1F,,CCOC(C)=O,,CC#N,CCN(CC)CC,val
US04783462,CC(C)n1ncc(NCC(O)CO)c(Cl)c1=O.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCC(O)CNc2cnn(C(C)C)c(=O)c2Cl)cc1,,ClCCl,,Cl,c1ccncc1,val
US20150291597A1,C#CCNc1nc(NCCC)cc(N(C)OC)n1.Cl>>C#CCNc1nc(NCCC)cc(N(C)OC)n1.Cl,,CCOCC,,,,val
US20150191461A1,O=C(O)c1cc[nH]c(=O)c1>>O=c1cc(CO)cc[nH]1,,C1CCOC1,,B,CO,val
US20140363454A1,CCOC(=O)[C@@H](C)C[C@H](Cc1ccccc1)NC(=O)c1csc([C@H](O)C[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H]2CCCCN2C(=O)OC(C)(C)C)[C@@H](C)CC)n1>>CC[C@H](C)[C@H](NC(=O)[C@H]1CCCCN1C(=O)OC(C)(C)C)C(=O)N(C)[C@H](C[C@@H](O)c1nc(C(=O)N[C@@H](Cc2ccccc2)C[C@H](C)C(=O)O)cs1)C(C)C,,CO,,[Na+].[OH-],,val
US20020022752A1,FC(F)=C(F)Cl.O=C(OC(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)F>>O=C(F)C(F)(F)C(F)(F)F,[Ni],O,,,,val
US20120101100A1,CCO.Nc1cc(Cl)nc(Cl)c1>>CCOc1cc(N)cc(Cl)n1,,O,,C,C[O-].[Na+],val
US20120309796A1,CC(C)(C)OC(=O)COc1cccc2c1CCCCC2NS(=O)(=O)c1ccc(Br)cn1.OB(O)c1cccc(C(F)(F)F)c1>>CC(C)(C)OC(=O)COc1cccc2c1CCCCC2NS(=O)(=O)c1ccc(-c2cccc(C(F)(F)F)c2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20150099777A1,CO.O=Cc1ccc(-c2ccc(F)cc2)c(F)c1F>>COc1c(C=O)ccc(-c2ccc(F)cc2)c1F,,CO,,C[O-].[Na+],,val
US05554607,CCNCC(=O)O.S=C=Nc1ccccc1Cl>>CCN1CC(=O)N(c2ccccc2Cl)C1=S,,ClCCl,,CCN(CC)CC,,val
US20150166480A1,COC(=O)c1ccc(-c2ccc(OCC3CCN(CC(C)(C)F)CC3)cc2F)cn1>>CC(C)(F)CN1CCC(COc2ccc(-c3ccc(C(=O)O)nc3)c(F)c2)CC1,,C1CCOC1,O,Cl,[Li]O,val
US04814345,CCN(CC)CCCNC(=O)c1c(OC)c2ccccc2n1-c1ccccc1.Cl>>CCN(CC)CCCNC(=O)c1c(O)c2ccccc2n1-c1ccccc1.Cl,,CO,,Cl,,val
US05807857,CCOC(=O)CCc1c[nH]c2cnc(-n3cncn3)cc12>>O=C(O)CCc1c[nH]c2cnc(-n3cncn3)cc12,,CO,,Cl,[Na+].[OH-],val
US20050267105A1,Cl.N#Cc1ncc(F)cc1F>>Cl.NCc1ncc(F)cc1F,[Pd],C1CCOC1,CCO,,,val
US20090298823A1,CC(C)(CN)CNc1nc(Cl)nc2[nH]ccc12.Nc1ccc2cn[nH]c2c1>>CC(C)(CN)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2[nH]ccc12,,CCCCO,,C[Si](C)(C)Cl,,val
US20040220191A1,CC(=O)CN[C@@H]1CCN(c2ccc(NC(=O)N3CCC(c4ccc(F)cc4)CC3)cc2)C1.CI>>CC(=O)CN[C@@H]1CCN(c2ccc(N(C)C(=O)N3CCC(c4ccc(F)cc4)CC3)cc2)C1,,CN(C)C=O,,O,[H-].[Na+],val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccc(Cl)nc3)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3ccc(Cl)nc3)c2)=C(C)C1=O,,CO,O,O=C([O-])O.[Na+],,val
US06723722B1,COC(=O)C(CNC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1.O=C(O)C(F)(F)F>>COC(=O)C(CN)NC(=O)OCc1ccccc1.O=C(O)C(F)(F)F,,Cc1ccccc1,,,,val
US05686458,COc1cccc2c(N3CCc4ccccc4[C@@H]3C)nc(Cl)nc12.Cc1cc(F)ccc1N>>COc1cccc2c(N3CCc4ccccc4[C@@H]3C)nc(Nc3ccc(F)cc3C)nc12.Cl,,CN(C)C=O,,,,val
US20120101079A1,C/C=C/B(O)O.Cc1cc(N2CCOCC2)nc(Cl)c1C(=O)NCc1cccc(F)c1>>C/C=C/c1nc(N2CCOCC2)cc(C)c1C(=O)NCc1cccc(F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,,val
US06018046,Cc1cn2c3ccc(Br)cc3c3cc(O)cc(c1=O)c32.OCCCCCl>>Cc1cn2c3ccc(Br)cc3c3cc(OCCCCO)cc(c1=O)c32,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080153799A1,CC(C)S(=O)(=O)Cl.CCc1ccccc1Nc1c(C(N)=O)cnc2cc(OC)c(O)cc12>>CCc1ccccc1Nc1c(C(N)=O)cnc2cc(OC)c(OS(=O)(=O)C(C)C)cc12,,CN1CCCC1=O,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20140200344A1,C[C@@H]1CCN(Cc2ccccc2)C[C@@H]1Nc1c(C=O)cnc2[nH]ccc12.C[Si](C)(C)CCOCCl>>C[C@@H]1CCN(Cc2ccccc2)C[C@@H]1Nc1c(C=O)cnc2c1ccn2COCC[Si](C)(C)C,,CN(C)C=O,,O,[H-].[Na+],val
US20060142303A1,COc1ccc(C=CC(=O)c2ccc(O)cc2)cc1.ClCC1CO1>>COc1ccc(C=CC(=O)c2ccc(OCC3CO3)cc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20050107304A1,COC(=O)C1CC2(CN1C(=O)C(NC(=O)C(NC(=O)c1cnccn1)C1CCCCC1)C(C)(C)C)SCCCS2>>CC(C)(C)C(NC(=O)C(NC(=O)c1cnccn1)C1CCCCC1)C(=O)N1CC2(CC1C(=O)O)SCCCS2,,C1CCOC1,O,[Li+].[OH-],,val
US20140080808A1,CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(C3(c4ccc(-c5cccc(C#N)n5)cc4)CC3)n2CCS1>>CC1(CO)Cc2nnc(C3(c4ccc(-c5cccc(C#N)n5)cc4)CC3)n2CCS1,,CO,,Cl,,val
US20020065283A1,CCOC=C(C(C)=O)C(=O)Nc1ccc(C(F)(F)F)cc1.NN>>Cc1n[nH]cc1C(=O)Nc1ccc(C(F)(F)F)cc1,,CCO,,O,,val
US20140073626A1,CC(C)(C)C(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Nc3ccc(C=C(C#N)C(N)=O)cc3)nc12>>CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(N)=O)cc3)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060229326A1,NC[C@H]1CCCC[C@H]1O.O=C(O)c1cnc(OCC2CC2)c(-c2ccc(F)cc2)c1>>O=C(NC[C@@H]1CCCC[C@@H]1O)c1cnc(OCC2CC2)c(-c2ccc(F)cc2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20070167486A1,COC(=O)CCC1=CCN(CCc2ccccc2F)C1=O.NO[K]>>O=C(CCC1=CCN(CCc2ccccc2F)C1=O)NO,,CO,ClC(Cl)Cl,CC(=O)O,,val
US20050256201A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.OCCCCc1cccc(Br)c1>>CC(C)(C)[Si](OCCCCc1cccc(Br)c1)(c1ccccc1)c1ccccc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20130045942A1,COc1ccc(CN)cc1OC.OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O>>COc1ccc(CNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1OC,,CCCO,,CCN(C(C)C)C(C)C,Cl,val
US05578627,Clc1ccc2onc(Cl)c2c1.OCC(Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)NC(c1ccccc1)(c1ccccc1)c1ccccc1>>Clc1ccc2onc(OCC(Cc3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)NC(c3ccccc3)(c3ccccc3)c3ccccc3)c2c1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US05239080,CCOC(=O)CCc1nc(-c2ccccc2)co1>>OCCCc1nc(-c2ccccc2)co1,,C1CCOC1,,CO,[BH4-].[Na+],val
US20060160794A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)CC(N)c1ccccc1Cl>>COC(=O)CC(NC(=O)OC(C)(C)C)c1ccccc1Cl,CN(C)c1ccncc1,,,c1ccncc1,,val
US20080255114A1,COC(=O)c1cccc(O)c1N.NC(n1ccnc1)n1ccnc1>>COC(=O)c1cccc2oc(N)nc12,,C1CCOC1,CCOC(C)=O,,,val
US20120245144A1,CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(-c3ccnn3C3CCN(C(=O)OC(C)(C)C)CC3)cc1OCC2>>CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(-c3ccnn3C3CCN(C)CC3)cc1OCC2,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20140155389A1,C1CCNC1.COc1cc(CC(=O)O)ccc1[N+](=O)[O-]>>COc1cc(CC(=O)N2CCCC2)ccc1[N+](=O)[O-],,O=S(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US06232338B1,O=C(Cl)C(=O)Cl.O=C(O)c1ccc(C(=O)NCc2ccc(Cl)c(Cl)c2)s1>>O=C(Cl)c1ccc(C(=O)NCc2ccc(Cl)c(Cl)c2)s1,CN(C)C=O,ClCCl,,,,val
US06995179B2,C#CC(=O)O.OCC=Cc1ccccc1>>C#CC(=O)OCC=Cc1ccccc1,CN(C)c1ccncc1,CCOCC,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05885999,O=[N+]([O-])c1ccccc1N1CCN(Cc2ccccc2)CC1>>Nc1ccccc1N1CCN(Cc2ccccc2)CC1,,CCO,,Cl[Sn]Cl,,val
US20120053173A1,CCC(=O)CC(=O)OC.COC(OC)N(C)C.NN>>CCc1n[nH]cc1C(=O)OC,,CCO,,O,,val
US20110275655A1,CC(C)(C)OC(=O)N[C@H]1COCC[C@@H]1O.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N[C@H]1COCC[C@@H]1OS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20110101854A1,CCSC(=Nc1ccccc1)C(C)C.NNC(=O)c1ccccc1>>CC(C)c1nnc(-c2ccccc2)n1-c1ccccc1,,CCCCO,,,,val
US20120258973A1,CNN.O=C(c1ccccc1)c1ccc(Cl)nc1Cl>>Cn1nc(-c2ccccc2)c2ccc(Cl)nc21,,CO,,,,val
US20160096858A1,CC(C)(C)[Si](C)(C)Cl.CN(C(=O)OC(C)(C)C)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2F)S1>>CN(C(=O)OC(C)(C)C)C1=N[C@H]2[C@H](O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](O)[C@@H]2F)S1,,CCOCC,CN(C)C=O,c1c[nH]cn1,,val
US20120083501A1,O=C(C1=CCCCC1)c1cc(Br)ccc1O>>O=C1c2cc(Br)ccc2OC2CCCCC12,,O,,Cl,[Na+].[OH-],val
US04167570,Cc1ccc2c(n1)Nc1ccccc1N(C)C2=O.ClCCCN1CCCC1>>Cc1ccc2c(n1)N(CCCN1CCCC1)c1ccccc1N(C)C2=O,,CN(C)C=O,,[H-].[Na+],,val
US20140243322A1,CC(C)(C)OC(=O)NCc1cccc(C2CCNCC2)c1.COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)O)c1nnc(C)n1-2>>COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)N1CCC(c3cccc(CNC(=O)OC(C)(C)C)c3)CC1)c1nnc(C)n1-2,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US20060074243A1,CC(C)(C)OC(=O)CS(=O)(=O)c1ccc(-c2ccc(CCC(F)(F)C(F)(F)F)cc2)cc1.ClCCN(CCCl)C1CC1>>CC(C)(C)OC(=O)C1(S(=O)(=O)c2ccc(-c3ccc(CCC(F)(F)C(F)(F)F)cc3)cc2)CCN(C2CC2)CC1,,CN(C)C=O,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20150018422A1,CCOC(=O)COc1cccc(COc2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)n2)c1>>COc1ccc(F)c(-c2ccc(OCc3cccc(OCC(=O)O)c3)nc2CC(C)(C)C)c1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20160083387A1,C=C1[C@@H](OC(C)=O)C[C@H]2[C@H](CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)[C@@H]([C@@]3(C)CC[C@H](OC(C)=O)C[C@@H]3COC(C)=O)CC[C@]12C>>C=C1[C@@H](OC(C)=O)C[C@H]2[C@H](CO)[C@@H]([C@@]3(C)CC[C@H](OC(C)=O)C[C@@H]3COC(C)=O)CC[C@]12C,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040063946A1,Cc1cccc(C(=O)Cc2ccnc(N)c2)c1.O=C(Cl)c1ccccc1>>Cc1cccc(C(=O)Cc2ccnc(NC(=O)c3ccccc3)c2)c1,,CC#N,,CCN(CC)CC,O,val
US20070298065A1,CC(C)(C)OC(=O)c1c[nH]nc1-c1ccc(Oc2ccccc2)cc1.IC1CCCC1>>CC(C)(C)OC(=O)c1cn(C2CCCC2)nc1-c1ccc(Oc2ccccc2)cc1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20140275179A1,O=Cc1sccc1Br.OB(O)c1ccc(Cl)cc1>>O=Cc1sccc1-c1ccc(Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20150252030A1,COC(=O)COc1cccc(C)c1C.NN>>Cc1cccc(OCC(=O)NN)c1C,,CCO,,,,val
US20080045532A1,CI.O=C(NCc1ccc(Br)cc1)N1CCCC1>>CN(Cc1ccc(Br)cc1)C(=O)N1CCCC1,,CN(C)C=O,,[H-].[Na+],,val
US20150232394A1,CCCCCCCCC(=O)C=Cc1ccc(CO)o1>>CCCCCCCCC(=O)C=Cc1ccco1,,CCO,,,,val
US20100062429A1,CN(C)CCNc1cccc2c1C(=O)c1cccc(Cl)c1C2=O.NCCO>>CN(C)CCNc1cccc2c1C(=O)c1cccc(NCCO)c1C2=O,,ClCCl,,,,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccco2)c1Cl.NCCNc1ccccc1>>Nc1nc(NCCNc2ccccc2)c(Cl)c(-c2ccco2)n1,,COCCOC,,,,val
US20030105133A1,Nc1ccc(C#CCCN2CCC(Cc3ccccc3)CC2)cc1N.O=C(c1ncc[nH]1)c1ncc[nH]1>>O=c1[nH]c2ccc(C#CCCN3CCC(Cc4ccccc4)CC3)cc2[nH]1,,C1CCOC1,CCOCC,,,val
US04406834,O=C(O)C(O)N1C(=O)CC1SC(c1ccccc1)(c1ccccc1)c1ccccc1>>O=C1CC(SC(c2ccccc2)(c2ccccc2)c2ccccc2)N1,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20070117854A1,FC(F)(F)c1cnn(CCl)c1.N#CC(C#N)CCC(F)(F)F>>N#CC(C#N)(CCC(F)(F)F)Cn1cc(C(F)(F)F)cn1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120252780A1,CC(C)(C)OC(=O)N1CCC(C)(C)C(=O)c2ccc(-c3cccc(Cl)c3)nc21>>CC1(C)CCNc2nc(-c3cccc(Cl)c3)ccc2C1=O,,CO,Cl,,,val
US20040097571A1,CS(=O)(=O)Cl.CSc1ccccc1CC[C@H](O)[C@H](C)OCc1ccccc1>>CSc1ccccc1CC[C@H](OS(C)(=O)=O)[C@H](C)OCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20110144081A1,CN(C(=O)Oc1ccc(F)cc1)[C@@H]1CN(C(=O)C2CCNCC2)C[C@H]1c1ccc(Cl)cc1.CS(=O)(=O)c1ccc(Br)nc1>>CN(C(=O)Oc1ccc(F)cc1)[C@@H]1CN(C(=O)C2CCN(c3ccc(S(C)(=O)=O)cn3)CC2)C[C@H]1c1ccc(Cl)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20160272596A1,CC(C)CC(=O)N1C[C@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(=O)Nc2ccccc21.COc1ccccc1CCl>>COc1ccccc1CN1C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)CN(C(=O)CC(C)C)c2ccccc21,,CN(C)C=O,O,[I-].[Na+],O=C([O-])[O-].[Cs+].[Cs+],val
US20130310395A1,CCCC[Sn](CCCC)(CCCC)c1[nH]ncc1F.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(I)c1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(-c2[nH]ncc2F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CS(C)=O,,,val
US20050239802A1,CCOC(=O)c1cc(NC(=O)CCCCl)cc(C2=C(c3cc(C(F)(F)F)ccc3OCc3ccccc3)CCC2)c1>>CCOC(=O)c1cc(C2=C(c3cc(C(F)(F)F)ccc3OCc3ccccc3)CCC2)cc(N2CCCC2=O)c1,,C1CCOC1,,O,[H-].[Na+],val
US20020143020A1,CC[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)OCc1c(F)ccc(Br)c1F.OO>>CC[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)OCc1c(F)ccc(O)c1F,,C1CCOC1,,CC(=O)O,[Li]CCCC,val
US20040044029A1,O=C1CC[C@H]2CN(C(=O)OCc3ccccc3)CC[C@H]12>>O=C1CC[C@@H]2CN(C(=O)OCc3ccccc3)CC[C@H]12,,CCN(CC)CC,,,,val
US07381841B2,Br.Nc1ccc(S(F)(F)(F)(F)F)cc1>>FS(F)(F)(F)(F)c1ccc(Br)cc1,,CC(=O)O,O,O=N[O-].[Na+],,val
US06777432B1,COC(=O)COc1ccc(C(=O)Nc2ccc(F)cc2)cn1.OCCc1ccccc1>>O=C(COc1ccc(C(=O)Nc2ccc(F)cc2)cn1)OCCc1ccccc1,O=S(=O)(O)O,Cc1ccccc1,,CCOC(C)=O,,val
US20120108589A1,CCc1c[nH]c2nccc(Cl)c12.C[Si](C)(C)CCOCCl>>CCc1cn(COCC[Si](C)(C)C)c2nccc(Cl)c12,,CN(C)C=O,,[H-].[Na+],,val
US20130345221A1,Cc1oc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)cc1C=O.NC(=O)C1CC1>>Cc1oc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)cc1CNC(=O)C1CC1,,Cc1ccccc1,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20060148858A1,COCOCCCc1c[nH]nc1C(C)C.Clc1cnc(Cl)c(Cl)c1>>COCOCCCc1cn(-c2ncc(Cl)cc2Cl)nc1C(C)C,,CN(C)C=O,,O,[H-].[Na+],val
US20070117988A1,Cc1ccc(S(=O)(=O)Cl)cc1.O[C@H]1CCN(C(c2ccccc2)c2ccccc2)C1>>Cc1ccc(S(=O)(=O)O[C@H]2CCN(C(c3ccccc3)c3ccccc3)C2)cc1,,ClCCl,,CCN(CC)CC,,val
US20130331378A1,CCOC(=O)c1cc(Cc2c(-c3ccccc3)nn3cc(OC)ccc23)cc([N+](=O)[O-])c1>>CCOC(=O)c1cc(N)cc(Cc2c(-c3ccccc3)nn3cc(OC)ccc23)c1,[Fe],CC(=O)O,CCO,O=C([O-])O.[Na+],,val
US20110263593A1,Nc1nc2ccc(Sc3cnc4ncccn34)cc2s1.O=C(Cl)c1ccccc1>>O=C(Nc1nc2ccc(Sc3cnc4ncccn34)cc2s1)c1ccccc1,,c1ccncc1,,,,val
US05686424,CC[C@H](C)[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)O.OC(c1ccccc1)C1CCCCC1>>CC[C@H](C)[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)OC(c1ccccc1)C1CCCCC1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20110319385A1,CCN(CC)S(F)(F)F.Cc1cc2c(cc1C(=O)N1CCc3cc(Cl)ccc31)[nH]c(=O)c1nnc(C(O)C3CC3)n12>>Cc1cc2c(cc1C(=O)N1CCc3cc(Cl)ccc31)[nH]c(=O)c1nnc(C(F)C3CC3)n12,,ClC(Cl)Cl,,ClCCl,O=C([O-])O.[Na+],val
US20150021555A1,COc1ccc(Cl)cc1B(O)O.Nc1ccncc1I>>COc1ccc(Cl)cc1-c1cnccc1N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O,O=C([O-])[O-].[K+].[K+],val
US20160096830A1,O=C(NCCCC[C@H](NC(=O)C1CCOCC1)C(=O)c1nc2ccccc2s1)OCc1ccccc1>>NCCCC[C@H](NC(=O)C1CCOCC1)C(=O)c1nc2ccccc2s1,,CC(=O)O,,Br,,val
US05750556,CCOC(=O)c1cc(=O)c2ccc([N+](=O)[O-])c(C)c2o1>>CCOC(=O)C1CCc2ccc(N)c(C)c2O1,[Pd],CC(=O)O,,,,val
US20130158067A1,CC(=O)c1cc(F)cc(F)c1O.O=C(CF)CF>>O=C1CC(CF)(CF)Oc2c(F)cc(F)cc21,,CO,,C1CCNC1,,val
US20040053814A1,Nc1ncccc1CO.O=C1CCC(=O)N1Br>>Nc1ncc(Br)cc1CO,,ClCCl,,,,val
US06255496B1,CCCCCCCCCCCCN(CCCC(=O)OCC)CCOc1ccc(CCC(OC)(OC)C(F)(F)F)cc1>>CCCCCCCCCCCCN(CCCC(=O)OCC)CCOc1ccc(CCC(=O)C(F)(F)F)cc1,,O=C(O)C(F)(F)F,,,,val
US20040082651A1,COC(OC)C(C)(C)C(=O)C(C)Br.O=Cc1ccccc1>>COC(OC)C(C)(C)C(=O)C(C)C(O)c1ccccc1,,C1CCOC1,,[I-].[Li+],,val
US20060148858A1,CC(C)(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.CCc1cccc(CC(=O)OC)c1O>>CCc1cccc(CC(=O)O)c1OCCCc1cn(-c2ccc(C(F)(F)F)cn2)nc1C(C)(C)C,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20080269218A1,CC(C)c1cc(C(=O)Nc2ccc(N3CCOCC3)cc2)c(OCc2ccccc2)cc1OCc1ccccc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)c1cc(C(=S)Nc2ccc(N3CCOCC3)cc2)c(OCc2ccccc2)cc1OCc1ccccc1,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20110172187A1,COC(=O)Cc1cc(NC(=O)C(F)(F)F)ccc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2.N>>NC(=O)Cc1cc(N)ccc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2,,CO,,O,,val
US20120264823A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H]1C[C@H]1c1ccc(Br)cc1>>CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(Br)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20160046596A1,COCCl.Cc1ncccc1O>>COCOc1cccnc1C,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US20160016937A1,Cc1ccccc1B(O)O.Clc1ncc(Br)cn1>>Cc1ccccc1-c1cnc(Cl)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04105776,CCOC(=O)[C@@H]1CCCN1C(=O)CCS.CI>>CSCCC(=O)N1CCC[C@H]1C(=O)O,,CCO,,[Na],,val
US20130281664A1,CC(C)PC(C)C.ClCc1cccc(-c2ccccn2)n1>>CC(C)P(Cc1cccc(-c2ccccn2)n1)C(C)C,,CO,,CCN(CC)CC,,val
US04877792,COC(=O)c1cc2c(cn1)[nH]c1ccc(Oc3ccc([N+](=O)[O-])cn3)cc12>>COC(=O)c1cc2c(cn1)[nH]c1ccc(Oc3ccc(N)cn3)cc12,[Pd],CO,,,,val
US20060160880A1,C=CCSc1ccccc1CN.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=CCSc1ccccc1CNC(=O)OC(C)(C)C,CN(C)c1ccncc1,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US05958905,Cc1noc(N)c1Br.O=P(Cl)(c1ccccc1)c1ccccc1>>Cc1noc(NP(=O)(c2ccccc2)c2ccccc2)c1Br,,C1CCOC1,,[H-].[Na+],,val
US20140242028A1,O=[N+]([O-])c1cc(Cl)c(Sc2ccc(C(F)(F)F)cc2)c(Cl)c1>>Nc1cc(Cl)c(Sc2ccc(C(F)(F)F)cc2)c(Cl)c1,[Fe],O,,CO,[Cl-].[NH4+],val
US06159967,COC(=O)CCC(=O)c1ccc(Cl)c(Cl)c1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1>>C=C(CCC(=O)OC)c1ccc(Cl)c(Cl)c1,,c1ccccc1,,O,CC(C)(C)[O-].[K+],val
US20060160802A1,COC(=O)C1(C=NOCc2ccccc2)CCC(C)(C)CC1>>CC1(C)CCC(C=NOCc2ccccc2)(C(=O)O)CC1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20150119373A1,CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C5(C)CC5)CC[C@]4(C(=O)Cl)CC[C@]23C)C1(C)C.COC1CCNCC1>>COC1CCN(C(=O)[C@]23CC[C@@H](C4(C)CC4)[C@@H]2[C@H]2CC[C@H]4[C@@](C)(CC[C@H]5C(C)(C)[C@@H](OC(C)=O)CC[C@@]54C)[C@]2(C)CC3)CC1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US06017426,CCCCCCCCCCCCCCCC(O)C(N)CO.CCCCCCCCCCCCCCCCCC(=O)O>>CCCCCCCCCCCCCCCCCC(=O)NC(CO)C(O)CCCCCCCCCCCCCCC,,CCCCCCC,CCOC(C)=O,,,val
US20050277652A1,C1CCN(C2CCNCC2)CC1.Nc1cc(Oc2ccc([N+](=O)[O-])cc2F)ncn1.O=C(Cl)Oc1ccccc1>>O=C(Nc1cc(Oc2ccc([N+](=O)[O-])cc2F)ncn1)N1CCC(N2CCCCC2)CC1,,C1CCOC1,CN(C)C=O,CCN(CC)CC,,val
US04362728,FC(F)(F)CN=C=S.Nc1cncc(Cl)n1>>FC(F)(F)CNC(=S)Nc1cncc(Cl)n1,,CC#N,,,,val
US05886233,C#CC1(O)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)C1C>>C#CC1=C(C)[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)C1,,c1ccncc1,,O=S(Cl)Cl,,val
US20060281700A1,CC(C)Oc1ccc(N)cc1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CC(C)Oc1ccc(NC(=O)Oc2ccc([N+](=O)[O-])cc2)cc1,,ClCCl,c1ccncc1,,,val
US20140114068A1,CC(C)c1ccc2c(c1)OC1(O)c3ccccc3C(=O)C21O.NN>>CC(C)c1ccc2c(c1)OC1(O)c3ccccc3C(=NN)C21O,,Cc1ccccc1,,O,,val
US05412097,Cc1ccc([N+](=O)[O-])c(N)n1.O=[N+]([O-])O>>Cc1nc(N)c([N+](=O)[O-])cc1[N+](=O)[O-],,O=S(=O)(O)O,,,,val
US20090221645A1,CC(Br)C(=O)c1ccc(Cl)c2ccccc12.S=C1NCCN1>>Br.CC1=C(c2ccc(Cl)c3ccccc23)N2CCN=C2S1,,CCO,,CC(=O)O,,val
US20160185798A1,Cc1ccc(C(=O)Cl)o1.Clc1cccc(C#CC2=C3CCNC3ON2)c1>>Cc1ccc(C(=O)N2CCC3C(C#Cc4cccc(Cl)c4)=NOC32)o1,,ClCCl,,CCN(CC)CC,O,val
US20130109649A1,COc1ccc([C@@H](O)[C@H](C)NC(=O)OCc2ccccc2)cc1Cl>>COc1ccc([C@H]2OC(=O)N[C@H]2C)cc1Cl,,C1CCOC1,,[H-].[Na+],,val
US20100331293A1,Cc1c(Cl)nc2cc(F)cc(F)c2c1Cl.Cc1ccc(B(O)O)c(C)c1>>Cc1ccc(-c2nc3cc(F)cc(F)c3c(Cl)c2C)c(C)c1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20090253681A1,CC(C)(C)OC(=O)CBr.CC1(C)NCCn2c1nc(C(=O)NCc1ccc(F)cc1)c(OCc1ccccc1)c2=O>>CC(C)(C)OC(=O)CN1CCn2c(nc(C(=O)NCc3ccc(F)cc3)c(OCc3ccccc3)c2=O)C1(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130281490A1,CC(C)(C)C(=O)Cl.CCOC(=O)CN(Cc1ccccc1)Cc1ccccc1>>CCOC(=O)[C@H](C(=O)C(C)(C)C)N(Cc1ccccc1)Cc1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20130245002A1,Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCC(O[Si](C)(C)C(C)(C)C)CC6)cc5c4)n3c2)cn1>>Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCC(O)CC6)cc5c4)n3c2)cn1,,CO,,Cl,,val
US20130210801A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2c(ccc(C)[n+]2[O-])c1Br.OB(O)C1=CCCCC1>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2c(ccc(C)[n+]2[O-])c1C1=CCCCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20110207731A1,C[Si](C)(C)CCOCCl.O=Cc1ccc2[nH]nc(I)c2c1>>C[Si](C)(C)CCOCn1nc(I)c2cc(C=O)ccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05719186,CCOC(=O)CBr.O=C1CCc2ccc(F)cc21>>CCOC(=O)CC1(O)CCc2ccc(F)cc21,[Zn],CCOCC,c1ccccc1,II,,val
US20070082853A1,BrCc1ccccc1.O=C(O)C(O)Cc1ccccc1>>O=C(OCc1ccccc1)C(O)Cc1ccccc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US03963742,ClCc1ccccc1.Oc1c(-c2ccccc2)n[nH]c1-c1ccccc1>>c1ccc(COc2c(-c3ccccc3)n[nH]c2-c2ccccc2)cc1,,O,,CO,C[O-].[Na+],val
US05206240,CS(=O)(=O)Nc1ccc(CCOS(C)(=O)=O)cc1.O=C(O)C(=O)O.O=C1CC2(CCCNC2)Oc2ccccc21>>CS(=O)(=O)Nc1ccc(CCN2CCCC3(CC(=O)c4ccccc4O3)C2)cc1.O=C(O)C(=O)O,,CCO,,O=C([O-])O.[Na+],,val
US20020103230A1,Nc1ccc(O)cc1[N+](=O)[O-].OCCN1CCOCC1>>Nc1ccc(OCCN2CCOCC2)cc1[N+](=O)[O-],,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04764519,Cc1cc(Br)cnc1CCCNc1ncc(Cc2cccnc2)cc1[N+](=O)[O-]>>Cc1cc(Br)cnc1CCCNc1ncc(Cc2cccnc2)cc1N,[Ni],CCO,CO,NN,O,val
US20120142668A1,C[C@@H](C(=O)N[C@H](/C=C/C(=O)N1[C@H]2CC[C@@H]1c1ccccc12)CCc1ccccc1)N(C(=O)[O-])C(C)(C)C.O=C(O)C(F)(F)F>>C[C@H](N)C(=O)N[C@H](/C=C/C(=O)N1[C@H]2CC[C@@H]1c1ccccc12)CCc1ccccc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20160194329A1,Cc1nc(N2CC(F)(F)C2)ccc1N.O=C(Cl)Oc1ccccc1>>Cc1nc(N2CC(F)(F)C2)ccc1NC(=O)Oc1ccccc1,,C1CCOC1,,c1ccncc1,O=C([O-])O.[Na+],val
US20050043544A1,CCOC(=O)C[Zn]Br.O=C1C(Cl)=C(Cl)C(=O)C(Cl)=C1Cl>>CCOC(=O)CC1(O)C(Cl)=C(Cl)C(=O)C(Cl)=C1Cl,,C1CCOC1,,CCOC(C)=O,Cl,val
US20060217382A1,COc1ccc(Nc2ncc(C(C)NC(=O)c3sccc3Br)nn2)cc1>>COc1ccc(Nc2ncc3c(C)nc(-c4sccc4Br)n3n2)cc1,,ClCCCl,,O=P(Cl)(Cl)Cl,,val
US20110190258A1,CC[C@@H](Nc1cccc(C=O)c1)c1ccc(Cl)c(C)c1.C[Mg]Br>>CC[C@@H](Nc1cccc(C(C)O)c1)c1ccc(Cl)c(C)c1,,C1CCOC1,,,,val
US20130252936A1,Clc1c(-c2ccccc2)nnc2[nH]nc(-c3ccccc3)c12.OC1COC1>>Clc1c(-c2ccccc2)nnc2c1c(-c1ccccc1)nn2C1COC1,,C1COCCO1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110092479A1,Nc1cc(CC(F)(F)F)n[nH]1.O=CC(C=O)[N+](=O)[O-]>>O=[N+]([O-])c1cnc2[nH]nc(CC(F)(F)F)c2c1,,O,,[Na],,val
US20100137281A1,CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1.COc1ccc(C(=O)CBr)cc1Br>>CCc1cc2c(=O)n(CC(=O)c3ccc(OC)c(Br)c3)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20140315963A1,CC(C)(C)OC(=O)CBr.O=c1[nH]c2cc(Cl)ccc2o1>>CC(C)(C)OC(=O)Cn1c(=O)oc2ccc(Cl)cc21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04659361,COC(=O)c1ccccc1S(=O)(=O)N=C=O.COc1cc(I)nc(N)n1>>COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(I)cc(OC)n1,,ClCCl,,,,val
US05153203,CCOC(=O)c1cn(C2CC2)c2c(F)c(OC3CCN(C(=O)OC(C)(C)C)C3)c(F)cc2c1=O>>CC(C)(C)OC(=O)N1CCC(Oc2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C1,,C1CCOC1,,[Na+].[OH-],,val
US20100190788A1,COC(=O)C[C@@H](NC(=O)OC(C)(C)C)c1ccc(C(=O)Nc2ccncc2)cc1>>CC(C)(C)OC(=O)N[C@H](CC(=O)O)c1ccc(C(=O)Nc2ccncc2)cc1,,C1COCCO1,,Cl,[Li+].[OH-],val
US20080113966A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](c2cccc(F)c2F)CNC1=O>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C2CCCCC2)CNC1=O,O=[Pt],CC(=O)O,,[H][H],,val
US20100022476A1,COc1cc(OC)c2c(Cl)ncnc2c1.Nc1cc(CC(=O)Nc2cccc(F)c2F)[nH]n1>>COc1cc(OC)c2c(Nc3cc(CC(=O)Nc4cccc(F)c4F)[nH]n3)ncnc2c1,,CC(C)O,,CCOCC,,val
US04954518,COC1COc2cc(NS(C)(=O)=O)c(Oc3ccccc3)cc2C1=O>>COc1coc2cc(NS(C)(=O)=O)c(Oc3ccccc3)cc2c1=O,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20150065705A1,O=C1CCC(N2C(=O)c3ccccc3C2=O)C1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C1c2ccccc2C(=O)N1C1C=C(OS(=O)(=O)C(F)(F)F)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05569664,Br.COc1cccc(OC)c1CO>>COc1cccc(OC)c1CBr,,CCOCC,,[Cl-].[Na+],,val
US04898862,CC1NC(=O)NN=C1c1ccc(O)cc1.CCOC(=O)CCl>>CCOC(=O)COc1ccc(C2=NNC(=O)NC2C)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20160272584A1,CC(=O)OC(C)=O.COc1cccc(-c2cc(C(=O)Nc3ccc(-c4ccc(OC5CCN(C)CC5)cc4N)cc3)ccc2OC)c1>>COc1cccc(-c2cc(C(=O)Nc3ccc(-c4ccc(OC5CCN(C)CC5)cc4NC(C)=O)cc3)ccc2OC)c1,,c1ccncc1,,,,val
US20100056576A1,CC1CC(c2ccncc2[N+](=O)[O-])=CC(O[Si](C)(C)C(C)(C)C)C1>>CC1CC(c2ccncc2N)=CC(O[Si](C)(C)C(C)(C)C)C1,[Fe],CC(=O)O,,,,val
US20090264650A1,COc1cc(C(=O)C2CCN(C3CCc4ccccc43)C2=O)n(C)n1>>COc1cc(C(O)C2CCN(C3CCc4ccccc43)C2=O)n(C)n1,,CO,,[BH4-].[Na+],,val
US06498251B1,CC(C)(C#N)N1CCN(Cc2ccccc2)CC1.c1ccccc1>>CC(C)(c1ccccc1)N1CCN(Cc2ccccc2)CC1,,CCOCC,,[Cl-].[NH4+],,val
US20140206663A1,CC(=O)C1CN(C(=O)OC(C)(C)C)C1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>C=C(OS(=O)(=O)C(F)(F)F)C1CN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US04818756,CCOC(=O)Cl.Nc1ccc2c(c1)S(=O)(=O)N(CCCCN1CCN(c3ncccn3)CC1)C2=O>>CCOC(=O)Nc1ccc2c(c1)S(=O)(=O)N(CCCCN1CCN(c3ncccn3)CC1)C2=O,,c1ccncc1,,,,val
US20100087427A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2O[Si](C)(C)C(C)(C)C)C(C)C)ccc1OC>>COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2O)C(C)C)ccc1OC,,C1CCOC1,,O,,val
US20150218187A1,CCOC(=O)C(=O)Nc1ccc(C2CCC3(CCC(CC(=O)OC)CC3)CC2)nc1.NN>>COC(=O)CC1CCC2(CC1)CCC(c1ccc(NC(=O)C(=O)NN)cn1)CC2,,CCO,,O,,val
US20090318690A1,C=CCBr.Cc1noc2c(O)cccc12>>C=CCOc1cccc2c(C)noc12,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20060122268A1,CC(C)C[C@H](O[C@@H](c1ccc(Br)cc1)c1cccs1)C(=O)NCC#N.OB(O)c1ccc(N2CCNCC2)cc1>>CC(C)C[C@H](O[C@@H](c1ccc(-c2ccc(N3CCNCC3)cc2)cc1)c1cccs1)C(=O)NCC#N,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20120010190A1,COc1ccc(C(=O)CC(c2ccccc2C)c2ccc(Br)cc2F)cn1>>Cc1ccccc1C(CC(=O)c1ccc(=O)[nH]c1)c1ccc(Br)cc1F,,C1COCCO1,,Cl,,val
US04358593,Cl.O=C(O)c1ccc(OCCN2CCCCC2)cc1.O=S(Cl)Cl>>Cl.O=C(Cl)c1ccc(OCCN2CCCCC2)cc1,CN(C)C=O,ClCCCl,,,,val
US20150274777A1,COc1ccc(C[C@H](NC(=O)[C@H](C)NS(=O)(=O)c2ccccc2C)C(=O)NC(Cc2ccccc2)[C@H](O)C(=O)NCc2ccccc2)cc1>>COc1ccc(C[C@H](NC(=O)[C@H](C)NS(=O)(=O)c2ccccc2C)C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCc2ccccc2)cc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20130115190A1,COCCBr.O=c1[nH]nc(Cl)c2ccccc12>>COCCn1nc(Cl)c2ccccc2c1=O,,O,,O=C([O-])[O-].[K+].[K+],,val
US20040023973A1,N#Cc1ccccc1-c1cc(-c2ccccn2)c[nH]c1=O.OCc1ccccc1>>N#Cc1ccccc1-c1cc(-c2ccccn2)cn(Cc2ccccc2)c1=O,,C1CCOC1,Cc1ccccc1,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06329381B1,FC(F)(F)CI.Nc1nc(S)nc2c1nc(O)n2Cc1ccccc1>>Nc1nc(SCC(F)(F)F)nc2c1nc(O)n2Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100087419A1,Cc1cc(CNC(=O)c2nc3n(c(=O)c2O)CC(C)(C)CC[C@@H]3N(C)C(=O)C(=O)N(C)C)ccc1F>>Cc1cc(CNC(=O)c2nc3n(c(=O)c2O)CC(C)(C)CC[C@H]3N(C)C(=O)C(=O)N(C)C)ccc1F,,CO,,,,val
US20160257645A1,COc1ccc(N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)cc1.Cl>>COc1ccc(N(C)C(=O)[C@@H](N)Cc2ccccc2)cc1.Cl,,C1CCOC1,,,,val
US04587261,CCOc1c(OC)cc(C(=O)NN)cc1OC.O=C1CCCC1=Cc1ccccc1>>CCOc1c(OC)cc(C(=O)NN=C2CCCC2=Cc2ccccc2)cc1OC,,CCO,,,,val
US04695578,COS(=O)(=O)OC.Cc1nccn1CC1CCc2[nH]c3ccccc3c2C1=O>>Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US03987052,CCCOc1cc2c(cc1Br)C(c1cccc(S(=O)CC)c1)=NCC(=S)N2.NNC(=O)Cc1ccccc1>>CCCOc1cc2c(cc1Br)C(c1cccc(S(=O)CC)c1)=NCc1nnc(Cc3ccccc3)n1-2,,CCO,,,,val
US20040186108A1,O=[N+]([O-])c1ccc(OCCCl)cc1.c1ccc2c(N3CCNCC3)nsc2c1>>O=[N+]([O-])c1ccc(OCCN2CCN(c3nsc4ccccc34)CC2)cc1,,CC#N,,Cl,[I-].[K+],val
US20060229206A1,NNC(=O)c1cccc(NC(=O)c2cccc(Cl)c2)c1.S=C=Nc1ccccc1Cl>>O=C(NNC(=S)Nc1ccccc1Cl)c1cccc(NC(=O)c2cccc(Cl)c2)c1,,C1CCOC1,,,,val
US07074801B1,CCOC(OCC)c1ccc(-c2ncnc3ccc(Br)cc23)s1>>O=Cc1ccc(-c2ncnc3ccc(Br)cc23)s1,,ClCCl,,O,O=C(O)C(F)(F)F,val
US07176310B1,CCOC(=O)CSc1ncc(C(=O)Nc2ccc(F)cc2)c(NCCNC(=O)OC(C)(C)C)n1>>CCOC(=O)CSc1ncc(C(=O)Nc2ccc(F)cc2)c(NCCN)n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20150258074A1,CI.Cc1nc(Cl)cc2c1c(=O)[nH]n2C(c1ccccc1)(c1ccccc1)c1ccccc1>>COc1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c2cc(Cl)nc(C)c12,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20160237090A1,COC(=O)CC(C(=O)OC)C(C)[N+](=O)[O-]>>COC(=O)C1CC(=O)NC1C,[Pd],CCO,,,,val
US20030191118A1,COC(=O)[C@H](Cc1ccc(-c2ccccc2N)cc1)NC(=O)c1c(Cl)cccc1Cl.CS(=O)(=O)Cl>>COC(=O)[C@H](Cc1ccc(-c2ccccc2NS(C)(=O)=O)cc1)NC(=O)c1c(Cl)cccc1Cl,,ClCCl,O,CCN(CC)CC,O=C(O)C(F)(F)F,val
US05668176,CC(C)(C)[Si](C)(C)Cl.CCCc1cc(CO)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2.ClCCl>>CCCc1cc(CO[Si](C)(C)C(C)(C)C)ccc1OC(C(=O)OC)c1ccc2c(c1)OCO2,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US04559345,CCOC(=S)Cc1nc(Cl)cc(Cl)n1.CNc1cccc(C)c1C>>CCOC(=S)Cc1nc(Cl)cc(N(C)c2cccc(C)c2C)n1,,CCO,,,,val
US20070099877A1,C=O.CO.COc1cc(N)cc(Nc2ncnc3ccsc23)c1>>COc1cc(Nc2ncnc3ccsc23)cc(N(C)C)c1,CC(=O)O,CO,,[BH3-]C#N.[Na+],,val
US20140201855A1,Clc1nc2ccc3c(c2s1)CCCN3.[C-]#N>>N#Cc1nc2ccc3c(c2s1)CCCN3,,CS(C)=O,,O,,val
US20120101124A1,CCOC(=O)CCCc1ccc(-c2noc(-c3ccc(OC(C)C)c(Cl)c3)n2)c2c1ccn2S(=O)(=O)c1ccc(C)cc1>>CCOC(=O)CCCc1ccc(-c2noc(-c3ccc(OC(C)C)c(Cl)c3)n2)c2[nH]ccc12,,C1CCOC1,,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20020198107A1,C=C(Br)CCC(=O)O.CCO>>C=C(Br)CCC(=O)OCC,CN(C)C=O,ClC(Cl)Cl,ClCCl,O=S(Cl)Cl,c1ccncc1,val
US20090082332A1,CCCCOc1nc(N)c2[nH]c(=O)n(CCCBr)c2n1.NC1CCN(Cc2ccccc2)CC1>>CCCCOc1nc(N)c2[nH]c(=O)n(CCCNC3CCN(Cc4ccccc4)CC3)c2n1,,CC#N,,Cl,,val
US20080312234A1,C#Cc1cc(CNC(=O)C=Cc2ccc(C(F)(F)F)nc2Cl)cc(F)c1NS(C)(=O)=O.CC(C)CO>>C#Cc1cc(CNC(=O)C=Cc2ccc(C(F)(F)F)nc2OCC(C)C)cc(F)c1NS(C)(=O)=O,,CN(C)C=O,O,Cl,[H-].[Na+],val
US04448781,CCOC(=O)COc1cccc(Cc2ncc[nH]2)c1.Cl>>Cl.O=C(O)COc1cccc(Cc2ncc[nH]2)c1,,CC#N,,,,val
US20080021032A1,CC(=O)Cl.c1ccc2c(c1)CCS2>>CC(=O)c1ccc2c(c1)CCS2,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20120323002A1,Cc1cccc(C=O)c1.Clc1cc(N2CCOCC2)c2nc(-c3cccnc3)cn2n1.NN>>Cc1cccc(C=NNc2cc(N3CCOCC3)c3nc(-c4cccnc4)cn3n2)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US05607956,CC(=O)c1cc2ccccc2o1.Cc1csc([Si](C)(C)C)n1>>Cc1ncsc1C(C)(O)c1cc2ccccc2o1,,CCOCC,,[Li]CCCC,,val
US20150336986A1,NC(N)=S.O=C1c2ccccc2C(=O)N1CC1CO1>>O=C1c2ccccc2C(=O)N1CC1CS1,,CO,,,,val
US20070004677A1,CC(C)(C)c1ccccc1Oc1ncccc1N=C=O.O=C(O)c1nc2ccccc2[nH]1>>CC(C)(C)c1ccccc1Oc1ncccc1NC(=O)c1nc2ccccc2[nH]1,,CN(C)C=O,,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,,val
US05760032,CCc1cc(C(=O)c2ccccc2Cl)c(-n2c(C)nnc2CNC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)s1>>CCc1cc(C(=O)c2ccccc2Cl)c(-n2c(C)nnc2CNC(=O)Nc2cccc(C(=O)O)c2)s1,,O=CO,,,,val
US20100041628A1,NC(=O)Nc1[nH]c2cc(-c3cccc(C=O)c3)ccc2c1C(N)=O>>NC(=O)Nc1[nH]c2cc(-c3cccc(CO)c3)ccc2c1C(N)=O,,C1CCOC1,CO,[BH4-].[Na+],,val
US20070213338A1,CC(=O)Cl.NCc1n[nH]c(=O)c2ccccc12>>Cc1ncc2c3ccccc3c(Cl)nn12,,CN(C)C=O,,CCN(CC)CC,,val
US20120302549A1,COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.NC1=N[C@@]2(CCSc3ccc(Br)cc32)C(F)(F)CO1>>COc1ccc(C(NC2=N[C@@]3(CCSc4ccc(Br)cc43)C(F)(F)CO2)(c2ccccc2)c2ccc(OC)cc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20030176454A1,Cc1ncn(-c2cccc(NC(N)=S)c2)c1C.O=C1CCc2ccccc2C1Cl>>Cc1ncn(-c2cccc(Nc3nc4c(s3)-c3ccccc3CC4)c2)c1C,,CCO,,,,val
US20140051692A1,C=CCBr.CC1(C)OB(c2cc3c(cc2F)OCCN3)OC1(C)C>>C=CCN1CCOc2cc(F)c(B3OC(C)(C)C(C)(C)O3)cc21,,CN(C)C=O,O,N#N,O=C([O-])[O-].[K+].[K+],val
US20070078165A1,CO[C@@H]1CNCC[C@H]1n1c(C)nc2cc(C)ccc21.O=C(O)[C@H]1Cc2ccc(Br)cc2C1.On1nnc2ccccc21>>CO[C@@H]1CN(C[C@H]2Cc3ccc(Br)cc3C2)CC[C@H]1n1c(C)nc2cc(C)ccc21.[NH4+].[OH-],,ClCCl,,CCN=C=NCCCN(C)C,,val
US20010034352A1,CCOC(=O)C1CCNCC1.O=C(O)C=Cc1cc2ccccc2o1>>CCOC(=O)C1CCN(C(=O)/C=C/c2cc3ccccc3o2)CC1,,CC#N,,O=S(Cl)Cl,c1ccncc1,val
US20110034481A1,CC(C)(C)OC(=O)N1CCc2cc(N)ccc2C1.CCOc1ccccc1N=C=O>>CCOc1ccccc1NC(=O)Nc1ccc2c(c1)CCN(C(=O)OC(C)(C)C)C2,,CCOC(C)=O,ClCCl,C1CCOC1,,val
US20040044008A1,N#Cc1cccc(CBr)c1.O=C(Nc1ccc(C2CCNCC2)cc1)c1ccccc1-c1ccc(C(F)(F)F)cc1>>N#Cc1cccc(CN2CCC(c3ccc(NC(=O)c4ccccc4-c4ccc(C(F)(F)F)cc4)cc3)CC2)c1,,CC(C)=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20080234319A1,C[C@H]1CCC[C@@](O)(CNC(=O)c2c(Cl)ccc3nc(Cl)ccc23)C1.O[C@H]1CCNC1>>C[C@H]1CCC[C@@](O)(CNC(=O)c2c(Cl)ccc3nc(N4CC[C@H](O)C4)ccc23)C1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20040167155A1,BrBr.COc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2c2ccccc2)cc1>>COc1ccc(S(=O)(=O)N2c3ccc(Br)cc3-c3ccccc3C2c2ccccc2)cc1,,CC(=O)O,CCOC(C)=O,O,[Cl-].[Na+],val
US20040034089A1,CCCc1[nH]c(C2Cc3ccccc3N2C(=O)OC(C)(C)C)nc1C(=O)O.On1nnc2ccccc21>>CCCc1[nH]c(C2Cc3ccccc3N2C(=O)OC(C)(C)C)nc1C(N)=O,,ClCCl,,O,,val
US20050080111A1,CC(C)(O)C#Cc1ccc(C#N)c(F)c1>>C#Cc1ccc(C#N)c(F)c1,,Cc1ccccc1,,[H-].[Na+],,val
US20090105258A1,COC(=O)C=Cc1ccc(C(C)(C)C)cc1NCC(C)C>>CC(C)CNc1cc(C(C)(C)C)ccc1C=CC(=O)O,,CO,O,Cl,[Na+].[OH-],val
US20120035178A1,Nc1cc2c(cn1)CCCC2.O=c1ccccn1C(=S)n1ccccc1=O>>S=C=Nc1cc2c(cn1)CCCC2,,CCCCCC,CCOC(C)=O,,,val
US06642228B1,CN(C)CCCCl.Cl.c1ccc2c(C3CCNCC3)c[nH]c2c1>>CN(C)CCCN1CCC(c2c[nH]c3ccccc23)CC1.Cl,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20150057271A1,N#Cc1cc(C(F)(F)F)ccc1N1CCOc2cc(S(=O)(=O)Oc3c(F)c(F)c(F)c(F)c3F)ccc21.Nc1ccno1>>N#Cc1cc(C(F)(F)F)ccc1N1CCOc2cc(S(=O)(=O)Nc3ccno3)ccc21,CC(=O)O,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100069349A1,CC(C)(C)C(=O)CC#N.NNCc1ccc(F)cc1>>CC(C)(C)c1cc(N)n(Cc2ccc(F)cc2)n1,,CCO,,Cl,Cl,val
US05391541,COc1cc(Cl)cc(CC(=O)O)c1Cl.O=S(Cl)Cl>>COc1cc(Cl)cc(CC(=O)Cl)c1Cl,,ClC(Cl)(Cl)Cl,,,,val
US20110313004A1,COC(=O)c1ccc(=O)oc1.Nc1ccccc1>>COC(=O)c1ccc(=O)n(-c2ccccc2)c1,,CCOC(C)=O,,c1ccncc1,,val
US20070173526A1,CCC1CC(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nc(C(F)(F)F)ccc2N1C(=O)OC(C)C.Cc1cc(C(=O)Cl)n(C)n1.c1ccncc1>>CC[C@H]1C[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)c2cc(C)nn2C)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C,,ClCCl,,,,val
US05234946,COCCl.O=Cc1ccc(O)c(O)c1>>COCOc1ccc(C=O)cc1O,,C1CCOC1,,CN(C)C=O,[H-].[Na+],val
US05151417,CC(C)OC(=O)OC(C)I.Nc1nc(/C(=N/O)C(=O)N[C@@H]2C(=O)N3C(C(=O)[O-])=C(/C=C\c4cncnc4)CS[C@H]23)cs1>>CC(C)OC(=O)OC(C)OC(=O)C1=C(/C=C\c2cncnc2)CS[C@@H]2[C@H](NC(=O)/C(=N\O)c3csc(N)n3)C(=O)N12,,CC(=O)N(C)C,,CCOC(C)=O,,val
US20110245257A1,CN.C[C@H](Nc1cccc(N)c1C#N)c1nc2cccc(C(=O)O)n2c1-c1cncc(F)c1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CNC(=O)c1cccc2nc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3cncc(F)c3)n12,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20040024201A1,CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](N2C(=O)c3ccccc3C2=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O.Cc1ccccc1S>>CC(=O)OC[C@H]1O[C@@H](Sc2ccc(C)cc2)[C@H](N2C(=O)c3ccccc3C2=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O,,ClCCl,,CCOCC,FB(F)F,val
US20090285782A1,O=P(Cl)(Cl)Cl.Oc1ncnc2ccc(-c3ccc(F)cc3)cc12>>Fc1ccc(-c2ccc3ncnc(Cl)c3c2)cc1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US03988471,C=C(C)C.CC(C)(C)c1cc(C(=S)S)cc(C(C)(C)C)c1O>>CC(C)(C)SC(=S)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,,Cc1ccccc1,,,,val
US05389680,CCCCN.O=C(Cl)CC(F)=C(F)F>>CCCCNC(=O)CC(F)=C(F)F,,ClCCl,,O,,val
US06303556B1,CC(C)=CCCC(C)=CC=O.C[Mg]Br>>CC(C)=CCCC(C)=CC(C)O,,CCOCC,CCOCC,,,val
US05272147,CCCc1nn(C)c2c(=O)[nH]c(-c3ccccc3OCC)nc12.O=[N+]([O-])O>>CCCc1nn(C)c2c(=O)[nH]c(-c3cc([N+](=O)[O-])ccc3OCC)nc12,,O=S(=O)(O)O,,O,,val
US20020120007A1,COc1ccc(C(=O)Nc2ccccc2N)cc1.O=C(Cl)c1ccc2ccccc2c1>>COc1ccc(C(=O)Nc2ccccc2NC(=O)c2ccc3ccccc3c2)cc1,,CCOC(C)=O,ClC(Cl)Cl,Cl,c1ccncc1,val
US20100094000A1,Cc1n[nH]c(-c2ccc(F)cc2)c1Br.OCCCF>>Cc1nn(CCCF)c(-c2ccc(F)cc2)c1Br,,C1CCOC1,CCOC(C)=O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04673686,CC1(CN)CCCN1C1=CCCCC1.COc1cc(S(N)(=O)=O)cc(C(=O)O)c1OC>>COc1cc(S(N)(=O)=O)cc(C(=O)NC(C)C2CCCN2C2=CCCCC2)c1OC,,CC(C)=O,O,CCN(CC)CC,CCOC(=O)Cl,val
US20060276450A1,COc1ccc2c(Cl)nc(C)c(-c3ccccc3)c2c1>>COc1ccc2c[nH+]c(C)c(-c3ccccc3)c2c1.[Cl-],[Pd],CCO,,[K+].[OH-],,val
US20100317684A1,CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)NS(C)(=O)=O.O=C(OC(=O)c1ccccc1)c1ccccc1>>CCOCc1nc2c(NC(=O)c3ccccc3)nc3ccccc3c2n1CC(C)(C)NS(C)(=O)=O,,CN(C)C=O,O,CCN(CC)CC,O=C([O-])O.[Na+],val
US04182881,ClP(Cl)(Cl)(Cl)Cl.NC(=O)c1ccc(-c2ccccc2)cc1.O=CO>>O=C(NP(=O)(Cl)Cl)c1ccc(-c2ccccc2)cc1,,ClC(Cl)(Cl)Cl,,Cl,,val
US20130281474A1,CC(C)(C)OC(=O)N1CCC(N)CC1.C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)c1cc(Cl)nc2c(-c3cnc4ccc(F)cc4c3)cnn12>>CC(C)(C)OC(=O)N1CCC(Nc2cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3ncc(-c4cnc5ccc(F)cc5c4)c3n2)CC1,,CN1CCCC1=O,O,O=C([O-])O.[Na+],,val
US20050272744A1,COC1(Cc2ccccc2F)CCN(c2ccc(C(=N)N)cc2)CC1.O=[N+]([O-])c1cc(S(=O)(=O)Cl)ccc1F>>COC1(Cc2ccccc2F)CCN(c2ccc(C(=N)NS(=O)(=O)c3ccc(F)c([N+](=O)[O-])c3)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20050197350A1,Cc1cnc(N[C@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)nc1N(C)C>>Cc1cnc(N[C@@H]2CC[C@H](N)CC2)nc1N(C)C,,CCOC(C)=O,,Cl,,val
US04427438,CC(C)Oc1cc(N)c(F)cc1Cl.O=C(Cl)Cl>>CC(C)Oc1cc(N=C=O)c(F)cc1Cl,,Cc1ccccc1,,,,val
US20110144090A1,O=C(O)c1cc2cc(F)c(OCc3ccccc3)cc2[nH]1>>Fc1cc2cc[nH]c2cc1OCc1ccccc1,[Cu],CN1CCCC1=O,,,,val
US20120101105A1,CCOC(=O)[C@@H]1C[C@H]1c1cn(C)c2ccccc12>>Cn1cc([C@@H]2C[C@H]2C(=O)O)c2ccccc21,,CO,,Cl,[Na+].[OH-],val
US20030069261A1,COC(=O)C1=C(C)N=C(OC)NC1c1ccc(F)c(F)c1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>COC(=O)C1=C(C)N=C(OC)N(C(=O)Oc2ccc([N+](=O)[O-])cc2)C1c1ccc(F)c(F)c1,CN(C)c1ccncc1,ClCCl,,,,val
US20150099777A1,CC1(C)OC(=O)c2cc(Br)c(OCc3ccccc3)cc2O1.CO>>CCOc1cc(OCc2ccccc2)c(Br)cc1C(=O)OC,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20080312255A1,CCOC(=O)c1sc(N)nc1C=O.N>>CCOC(=O)c1sc(N)nc1C#N,,C1CCOC1,,II,,val
US06576787B1,C1CC[C@H]2CCCC[C@H]2C1.CC(=O)C(C)=O.O=C1c2ccccc2C(=O)N1O>>CC(=O)[C@]12CCCC[C@@]1(O)CCCC2,,CC(=O)O,,O=O,,val
US05607922,Nc1nc(Cl)c2ncn([C@@H]3CO[C@H](CO)[C@@H](O)C3)c2n1.Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O>>Nc1nc2c(ncn2[C@@H]2CO[C@H](CO)[C@@H](O)C2)c(=O)[nH]1,,O=P([O-])([O-])[O-],,,,val
US20060004003A1,COC(=O)CC(=O)C1CC1.O=CC1CCCCC1>>COC(=O)C(=CC1CCCCC1)C(=O)C1CC1,,CO,,C1CCNCC1,,val
US20150259354A1,CCOC(=O)C=C1CCN(Cc2ccccc2)CC1.N#Cc1c(-c2ccc(Oc3ccccc3)cc2)n[nH]c1N>>N#Cc1c(-c2ccc(Oc3ccccc3)cc2)nn2c1NC(=O)CC21CCN(Cc2ccccc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100021423A1,COc1ncccc1-c1cc(N)c(OC)c(C(C)(C)C)c1.O=C(O)c1ccc(OCc2ccccc2)c(F)c1>>COc1ncccc1-c1cc(NC(=O)c2ccc(OCc3ccccc3)cc2F)c(OC)c(C(C)(C)C)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100190764A1,COC(=O)C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CCN1>>O=C(O)C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CCN1,,CO,O,[Li+].[OH-],,val
US20100331320A1,C[C@@H](c1ccc(Br)cc1)N1CC[C@](CCCO)(c2ccc(F)cc2)OC1=O.Nc1ccc(B(O)O)cn1>>C[C@@H](c1ccc(-c2ccc(N)nc2)cc1)N1CC[C@](CCCO)(c2ccc(F)cc2)OC1=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05057513,NCCS.O=C(O)C=C1CCCCC1Cc1ccccc1>>O=C1CC2(CCCCC2Cc2ccccc2)SCCN1,,CCOC(C)=O,CN(C)C=O,,,val
US20110172230A1,CNc1ccccc1N.O=C(O)c1cccc(NC(=O)N2CCC(Oc3ccc(OCc4ccccc4)cc3)CC2)c1>>CNc1ccccc1NC(=O)c1cccc(NC(=O)N2CCC(Oc3ccc(OCc4ccccc4)cc3)CC2)c1,,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20090062251A1,CC(C)(C)OC(=O)NC1CCCNC1.Cn1c2c(c3cc(C(=O)O)ccc31)CC(C1CCOCC1)CC2>>Cn1c2c(c3cc(C(=O)N4CCCC(NC(=O)OC(C)(C)C)C4)ccc31)CC(C1CCOCC1)CC2,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04724236,C#CCC(C)(C(=O)OCC)C(=O)OCC>>C#CCC(C)(C(=O)O)C(=O)O,,CCO,O,[K+].[OH-],,val
US06300352B1,C[C@H](Oc1ccc(B(O)O)cc1)[C@@H](CCc1cccnc1)O[Si](C)(C)C(C)(C)C.Cc1cc(C#N)ccc1Br>>Cc1cc(C#N)ccc1-c1ccc(O[C@@H](C)[C@H](O)CCc2cccnc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20040019072A1,CC(=O)c1cc2c(cc1O)C(C)(C)CCC2(C)C.CC(C)=CCBr>>CC(=O)c1cc2c(cc1OCC=C(C)C)C(C)(C)CCC2(C)C,,CS(C)=O,,,,val
US20050192325A1,COC(=O)/C=C/c1c(F)cc(NC(=O)OC(C)C)cc1F>>CC(C)OC(=O)Nc1cc(F)c(/C=C/CO)c(F)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US03940394,CCOC(=O)CBr.O=c1cc(-c2ccccc2)[nH]c(=S)[nH]1>>CCOC(=O)CSc1nc(O)cc(-c2ccccc2)n1,,CCO,,O,O=C([O-])O.[Na+],val
US20150225412A1,CC(C)(C)OC(=O)N1CC(CNc2ccccc2N)C1.N#CBr>>CC(C)(C)OC(=O)N1CC(Cn2c(N)nc3ccccc32)C1,,CCO,,,,val
US20070071782A1,CCN.Cc1c(Cl)ccc(S(=O)(=O)Cl)c1C#N>>CCNS(=O)(=O)c1ccc(Cl)c(C)c1C#N,,C1CCOC1,O,Cl,,val
US20120149694A1,CCS.O=C(N1CCOCC1)N1CC(CS(=O)(=O)[O-])CC(c2ccc(C(F)(F)F)cc2)C1>>CCSCC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1,,CN(C)C=O,,O,[H-].[Na+],val
US20100173886A1,NC(=O)c1ccc(O)cc1.O=Cc1cnc(Cl)c2ccccc12>>NC(=O)c1ccc(Oc2ncc(C=O)c3ccccc23)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20140024649A1,CN(C)c1cccc(O)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN(C)c1cccc(OC(=O)Cl)c1,,C1CCOC1,,[H-].[Na+],,val
US20040220408A1,CSC(=N)N(C#N)c1ccncc1.NCCCCCCOc1cccnc1>>N#CNC(=Nc1ccncc1)NCCCCCCOc1cccnc1,CN(C)c1ccncc1,c1ccncc1,,CCN(CC)CC,,val
US04769482,CCCc1c(O)ccc(C(C)=O)c1O.N#CCCCCCCl>>CCCc1c(OCCCCC#N)ccc(C(C)=O)c1O,,CCC(C)=O,,[I-].[K+],,val
US07015218B1,N#Cc1cc([N+](=O)[O-])ccc1N1CCC(=O)CC1.NCCO>>N#Cc1cc([N+](=O)[O-])ccc1N1CCC(NCCO)CC1,,C1CCOC1,CO,Cl,[BH3-]C#N.[Na+],val
US04906621,CCOC(=O)c1cc(CO)ccn1>>CCOC(=O)C1CC(CO)CCN1,O=[Pt],CC(=O)O,,,,val
US04976773,CNS(=O)(=O)c1ccc(NC(C)=O)cc1>>CNS(=O)(=O)c1ccc(N)cc1,,CO,,Cl,,val
US20090306066A1,CC1(O)CCN(c2nc(Cl)nc(Cl)c2F)C1.NN>>CC1(O)CCN(c2nc(Cl)nc(NN)c2F)C1,,CS(C)=O,,O,,val
US20040122057A1,C#CCOC1CCCCO1.COC(C(=O)NCc1ccc(C#N)cc1)c1c(F)cccc1OS(=O)(=O)C(F)(F)F>>COC(C(=O)NCc1ccc(C#N)cc1)c1c(F)cccc1C#CCOC1CCCCO1,,CN(C)C=O,,,,val
US20050054679A1,CC(C)(C)OC(=O)c1cn(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)n1.CSSC>>CSc1c(C(=O)OC(C)(C)C)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(Cl)cc1,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20140081017A1,CCOC(=O)Cc1csc(CCCCc2ccccc2)n1>>O=C(O)Cc1csc(CCCCc2ccccc2)n1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20030036655A1,[N-]=[N+]=NCc1ccc(Cc2ccc([N+](=O)[O-])cc2)cc1>>NCc1ccc(Cc2ccc([N+](=O)[O-])cc2)cc1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090215827A1,COC(=O)c1ccc2ccccc2c1O.FC(F)(F)c1ccc(CBr)cc1>>COC(=O)c1ccc2ccccc2c1OCc1ccc(C(F)(F)F)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070213331A1,CCCS(=O)(=O)c1cc(C(=O)OC)cc(N[C@@H](C)CC)n1>>CCCS(=O)(=O)c1cc(C(=O)O)cc(N[C@@H](C)CC)n1,,CO,,[Na+].[OH-],,val
US06506760B1,Cc1c(Cl)nc(NN)c(=O)n1CC(=O)O.O=C(Cl)OCc1ccccc1>>Cc1c(Cl)nc(NNC(=O)OCc2ccccc2)c(=O)n1CC(=O)O,,C1COCCO1,O,O=C([O-])O.[Na+],,val
US05753664,NCCCO.O=C(c1ccc(Cl)cc1)c1ccc(CBr)cc1>>O=C(c1ccc(Cl)cc1)c1ccc(CNCCCO)cc1,,CCO,,,,val
US20060293319A1,COc1ccc(CCl)cc1.COc1cccc(C2C(=O)Nc3cc(Cl)ccc32)c1>>COc1ccc(CC2(c3cccc(OC)c3)C(=O)Nc3cc(Cl)ccc32)cc1,,CC(C)=O,CCOC(C)=O,[I-].[K+],,val
US06362177B1,CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)c([N+](=O)[O-])c2)C1>>CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)c(N)c2)C1,[Pd],CO,,CCOC(C)=O,,val
US20110003787A1,CI.Sc1ccc(Cl)nn1>>CSc1ccc(Cl)nn1,,CO,,O,C[O-].[Na+],val
US20140031368A1,CC(C)(C)OC(=O)C(C)(C(=O)OC(C)(C)C)c1ccc(N)cc1.COC(=O)CCCCCCC(=O)[O-]>>COC(=O)CCCCCCC(=O)Nc1ccc(C(C)(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1,,ClCCl,,CCN=C=NCCCN(C)C,,val
US20140094474A1,CCOC(=O)c1c[nH]c(C)n1.C[C@H]1CO1>>CCOC(=O)c1cn(C[C@H](C)O)c(C)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100009969A1,CC1CCCN1CCCOc1ccc(-c2nc3c(s2)CCCN3)cc1.O=S(=O)(Cl)N1CCOCC1>>CC1CCCN1CCCOc1ccc(-c2nc3c(s2)CCCN3S(=O)(=O)N2CCOCC2)cc1,,ClCCl,O,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US04794181,Cc1ccc(S(=O)(=O)N2CCc3ccccc3C(O)C2)cc1.Oc1ccccc1>>Cc1ccc(S(=O)(=O)N2CCc3ccccc3C(Oc3ccccc3)C2)cc1,,c1ccccc1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090156590A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C(C)c1ccc2nc(N)sc2c1>>CCOC(=O)C(C)c1ccc2nc(NC(=O)OC(C)(C)C)sc2c1,,C1COCCO1,,O,,val
US20090029903A1,CCCCCCN(Cc1ccc(C#Cc2ccc(CCCC)cc2)cc1)C(=O)c1ccc2c(c1)C(=O)OC(C)(C)O2>>CCCCCCN(Cc1ccc(C#Cc2ccc(CCCC)cc2)cc1)C(=O)c1ccc(O)c(C(=O)O)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20150050239A1,C1COCCN1.Cc1c(C(=O)Nc2ccc(Oc3ccnc(N)c3)c(Cl)c2)c(=O)n(-c2ccccc2)n1C.O=C(Cl)Oc1ccccc1>>Cc1c(C(=O)Nc2ccc(Oc3ccnc(NC(=O)N4CCOCC4)c3)c(Cl)c2)c(=O)n(-c2ccccc2)n1C,,C1CCOC1,,CCN(CC)CC,,val
US04165377,CNC(SC)=C(C#N)C#N.N=C(N)Nc1nc(CCCCN)cs1>>CNC(NCCCCc1csc(NC(=N)N)n1)=C(C#N)C#N,,CC#N,,,,val
US04943585,ClCn1cnnc1Cl.Oc1ccc(Oc2ccccc2)cc1>>Clc1nncn1COc1ccc(Oc2ccccc2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160009704A1,[N-]=[N+]=[N-].c1ccc(COC[C@H]2CO2)cc1>>[N-]=[N+]=NC[C@@H](O)COCc1ccccc1,,CO,O,[Cl-].[NH4+],,val
US20040142999A1,Brc1nccs1.CON(C)C(=O)[C@H](CCc1ccccc1)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@@H](CCc1ccccc1)C(=O)c1nccs1,,C1CCOC1,CCOCC,[Li]CCCC,,val
US04714698,C1CNCCN1.CCN(C)c1nc(Cl)nc2c(SC)ncnc12>>CCN(C)c1nc(N2CCNCC2)nc2c(SC)ncnc12,,CS(C)=O,,,,val
US20130324536A1,CC(C)(C)C(=O)C(F)C#N.NN>>CC(C)(C)c1n[nH]c(N)c1F,,CCO,,,,val
US06605635B1,NCc1ccc(O)cc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=S(=O)(NCc1ccc(O)cc1)c1ccc(Cl)cc1,,CCO,,CCN(CC)CC,,val
US20060241106A1,CC(=O)c1ccc(OCc2ccccc2)cc1OCc1ccccc1.O=C1CCC(=O)N1Br>>CC(=O)c1cc(Br)c(OCc2ccccc2)cc1OCc1ccccc1,,CN(C)C=O,,O,,val
US20150031648A1,O=C([C@@H]1Cc2ccccc2CN1C(=O)OCc1ccccc1)N1CCOCC1>>O=C(OCc1ccccc1)N1Cc2ccccc2C[C@H]1CN1CCOCC1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20030199552A1,O=C(O)c1cc2cc3oc(=O)[nH]c3cc2o1.c1ccc(CC2CCNCC2)cc1>>O=C(c1cc2cc3oc(=O)[nH]c3cc2o1)N1CCC(Cc2ccccc2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120088750A1,CCOC(=O)C(C)(Br)C(=O)OCC.Nc1ncc(Br)cc1O>>CCOC(=O)C1(C)Oc2cc(Br)cnc2NC1=O,,CN(C)C=O,,[F-].[K+],,val
US20020120146A1,BrCc1ccccc1.CC(C)(C)OC(=O)N1CCC(c2nnn[nH]2)CC1>>CC(C)(C)OC(=O)N1CCC(c2nnn(Cc3ccccc3)n2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20120065214A1,CC(C)(N)c1ccccc1OCc1ccccc1.CCOC(=O)c1cc(F)c(C)c(-n2cc(Br)nc(Br)c2=O)c1>>CCOC(=O)c1cc(F)c(C)c(-n2cc(Br)nc(NC(C)(C)c3ccccc3OCc3ccccc3)c2=O)c1,,C1COCCO1,O,CCN(C(C)C)C(C)C,,val
US03931177,ClCc1ccccc1.Oc1ccc(Br)cc1N1CCOCC1>>Brc1ccc(OCc2ccccc2)c(N2CCOCC2)c1.Cl,,O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US04579842,CC(CCl)Cc1ccc(Br)cc1.CC[Si](Cl)(CC)CC>>CC[Si](CC)(CC)c1ccc(CC(C)CCl)cc1,,C1CCOC1,,[Mg],,val
US20100099673A1,Cn1cnc(S(=O)(=O)Cl)c1.OC1(c2ccccc2)CCN[C@H]2CCCC[C@H]21>>Cn1cnc(S(=O)(=O)N2CCC(O)(c3ccccc3)[C@@H]3CCCC[C@@H]32)c1,,ClCCl,,,,val
US03950393,CC(=O)Nc1ccc(C(C)(C)C)cc1CBr.CNC1CCCCC1>>CC(=O)Nc1ccc(C(C)(C)C)cc1CN(C)C1CCCCC1,,ClC(Cl)(Cl)Cl,,,,val
US20100168418A1,BrCCSc1cccs1.CCOC(=O)C1(CCCn2c(=O)ccc3ccc(OC)cc32)CCNCC1>>CCOC(=O)C1(CCCn2c(=O)ccc3ccc(OC)cc32)CCN(CCSc2cccs2)CC1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100278833A1,COC(=O)c1sc(-n2cnc3ccncc32)cc1OCc1ccccc1C(F)(F)F.N>>NC(=O)c1sc(-n2cnc3ccncc32)cc1OCc1ccccc1C(F)(F)F,,CO,,,,val
US20060293328A1,C1COCCO1.CCO.O.O=Cc1ccc(-c2ccc(Br)cn2)cc1>>O=Cc1ccc(-c2ccc(-c3ccc(C=O)o3)cn2)cc1,,O,,,,val
US20110046110A1,C1CCNC1.Nc1cc(Cl)ccn1>>Nc1cccc(N2CCCC2)n1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20050209260A1,CC(C)c1cc(O)ccc1Cl.CC(C)c1ccc(Cl)c(O)c1.CI.CN(C)C=O>>COc1cc(C(C)C)ccc1Cl.COc1ccc(Cl)c(C(C)C)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20110288091A1,CCOC=C(C(=O)[O-])C(=O)OCC.Nc1ccc(Cl)cc1>>CCOC(=O)c1c[nH]c2ccc(Cl)cc2c1=O,,CCOC(C)=O,O,Cl,[Na+].[OH-],val
US20030087874A1,CC(C)[C@H](O)[C@H](N[C@H](CO)c1ccccc1)C(=O)OC(C)(C)C>>CC(C)[C@H](O)[C@H](N)C(=O)OC(C)(C)C,[Pd],CO,,,,val
US20160143895A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c([C@@H]3CCCNC3)cc12.O=C(O)c1cc2cccc(C(F)(F)F)c2[nH]1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c([C@@H]3CCCN(C(=O)c4cc5cccc(C(F)(F)F)c5[nH]4)C3)cc12,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,CCN=C=NCCCN(C)C,val
US20130072679A1,CCS(=O)(=O)NCc1cncc(Br)c1.CN1C(=O)CCc2cc(B3OC(C)(C)C(C)(C)O3)cc(F)c21>>CCS(=O)(=O)NCc1cncc(-c2cc(F)c3c(c2)CCC(=O)N3C)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],,val
US06235355B1,CCCC(CO)CO.Cc1ccccc1.O=CC1CCC(c2cc(F)c(F)c(F)c2)CC1>>Fc1cc(C2CCC(C3OCCCO3)CC2)cc(F)c1F,,Cc1ccccc1,,,,val
US20050009843A1,CC(C)(C)OC(=O)/C=C/c1c(N2CCC[C@@H](OC(=O)NCCCl)C2)nc2cc(C(=O)Nc3nc(C(C)(C)C)cs3)ccn2c1=O>>CC(C)(C)c1csc(NC(=O)c2ccn3c(=O)c(/C=C/C(=O)O)c(N4CCC[C@@H](OC(=O)NCCCl)C4)nc3c2)n1,,C1COCCO1,,Cl,,val
US20100298347A1,CCOC(=O)c1cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1.CS(=O)(=O)O>>CCOC(=O)c1cc(-c2ccc(C3CC[NH2+]CC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1.CS(=O)(=O)[O-],,C1CCOC1,,,,val
US20120040985A1,COc1cc(C(C)(C)c2cnc(SCc3c(F)cc(OCCCO[Si](C)(C)C(C)(C)C)cc3Cl)n2-c2ccc(F)cc2)ccc1F>>COc1cc(C(C)(C)c2cnc(SCc3c(F)cc(OCCCO)cc3Cl)n2-c2ccc(F)cc2)ccc1F,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040143007A1,BrCC1CCC1.N#CC(C#N)Cc1ccc(OC(F)(F)F)cc1>>N#CC(C#N)(Cc1ccc(OC(F)(F)F)cc1)CC1CCC1,,CN(C)C=O,,[H-].[Na+],,val
US05318966,CCC(=O)N1CC[C@@H]2c3cccc(OC)c3CC[C@@H]21>>CCCN1CC[C@@H]2c3cccc(OC)c3CC[C@@H]21,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20060247250A1,CC(C)N(CCO)C(=O)c1ccc(Nc2ncc([N+](=O)[O-])cn2)cc1>>CC(C)N(CCO)C(=O)c1ccc(Nc2ncc(N)cn2)cc1,[Pd],C1CCOC1,CO,,,val
US20090004185A1,CCOC(=O)N=C=S.Nc1cccc(I)c1>>CCOC(=O)NC(=S)Nc1cccc(I)c1,,ClCCl,,,,val
US20010021777A1,Clc1ccc2c(ccn2C2=CCN(CCC3Cc4ccccc4C3)CC2)c1>>Clc1ccc2c(ccn2C2CCN(CCC3Cc4ccccc4C3)CC2)c1,O=[Pt],CC(=O)O,,[H][H],,val
US04318913,C1CCNCC1.Cn1nc(N)nc1NCCCOc1cccc(CBr)c1>>Cn1nc(N)nc1NCCCOc1cccc(CN2CCCCC2)c1,,CCO,,Br,,val
US20050197331A1,Nc1cc([N+](=O)[O-])ccc1[S-].O=C(O)c1ccccc1>>O=[N+]([O-])c1ccc2sc(-c3ccccc3)nc2c1,,O,,[Na+].[OH-],,val
US20160257682A1,CC(C)n1nc(N2CCN(C(=O)OC(C)(C)C)C2=O)c2cnc(Nc3ccnc(N4CC[C@H](O)[C@H](F)C4)n3)cc21>>CC(C)n1nc(N2CCNC2=O)c2cnc(Nc3ccnc(N4CC[C@H](O)[C@H](F)C4)n3)cc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040082611A1,CN(C)C(=O)Cl.O=C(c1ccc(-c2cc[n+]([O-])cc2)cc1)N1CCN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CC1>>N#Cc1cc(-c2ccc(C(=O)N3CCN(S(=O)(=O)c4ccc5cc(Cl)ccc5c4)CC3)cc2)ccn1,,ClCCl,,O=C([O-])O.[Na+],,val
US20070049606A1,CCOC(=O)c1nc2n(c(=O)c1OCc1ccccc1)CCN2Cc1ccccc1>>O=C(O)c1nc2n(c(=O)c1OCc1ccccc1)CCN2Cc1ccccc1,,CCOC(C)=O,,,,val
US20150023913A1,CCOC(=O)C1(COS(=O)(=O)C(F)(F)F)CCCCO1.[N-]=[N+]=[N-]>>CCOC(=O)C1(CN=[N+]=[N-])CCCCO1,,O,,CN(C)C=O,,val
US20040009995A1,CI.CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(C2(O)CCOCC2)c1.O=C(O)C(F)(F)F>>COC1(c2cccc(S(=O)(=O)c3cc(C(=N)N)sc3SC)c2)CCOCC1.O=C(O)C(F)(F)F,,CN(C)C=O,,[H-].[Na+],,val
US05344928,CCOC(=O)CCCN(C)c1ccccc1.O=N[O-]>>CCOC(=O)CCCN(C)c1ccc(N)cc1,[Zn],O,,Cl,,val
US20160096893A1,CC(C)(C)OC(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21.Cl>>Cl.Oc1cc2c(c3ccccc13)[C@H](CCl)CN2,,ClCCl,,C1COCCO1,,val
US04423045,CCO.CCOC(=O)COc1ccc(C#N)cc1.Cl>>CCOC(=N)c1ccc(OCC(=O)OCC)cc1.Cl,,CCO,,CCOCC,,val
US20160102083A1,CC(C)(C)OC(=O)N1CCC(C(Br)CCCC=O)CC1.COC(=O)c1csc(N)c1C>>COC(=O)c1csc(N2CCCCC2C2CCN(C(=O)OC(C)(C)C)CC2)c1C,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20130172312A1,CC(=O)N[C@@H](C)c1ccc(N2CC(Oc3ccc(OCc4ccccc4)cc3)C2)cc1>>CC(=O)N[C@@H](C)c1ccc(N2CC(Oc3ccc(O)cc3)C2)cc1,[Pd],CO,,,,val
US04521422,CC(=O)c1cccnc1.CCN(CC)C(OC)OC>>CCN(C=CC(=O)c1cccnc1)CC,,C1COCCO1,,,,val
US20110003807A1,CON(C)C(C)=O.Cc1nc(-c2ccccc2)c(-c2ncn(C3CCCCO3)n2)s1>>CC(=O)Cc1nc(-c2ccccc2)c(-c2ncn(C3CCCCO3)n2)s1,,C1CCOC1,CC(=O)O,CCCCCC,[Li]CCCC,val
US20040092740A1,O=C(O)c1ccoc1.O=C=O>>O=C(O)c1ccoc1C(=O)O,,C1CCOC1,,[Li]CCCC,,val
US20070049581A1,CCOC(=O)C(C)N1CCC(N2CCN(C(=O)[C@@H](Cc3cc(Cl)c(N)c(C(F)(F)F)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1>>CC(C(=O)O)N1CCC(N2CCN(C(=O)[C@@H](Cc3cc(Cl)c(N)c(C(F)(F)F)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1,,C1CCOC1,O,[Li+].[OH-],,val
US20160264552A1,CNC.N#Cc1cnc(N[C@@H]2CCN(C(=O)c3ccc(N)cc3)C2)nc1-c1c[nH]c2ccccc12.O=C(Cl)/C=C/CBr>>CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc(C#N)c(-c4c[nH]c5ccccc45)n3)C2)cc1,,C1CCOC1,,,,val
US20030036534A1,COC(=O)c1cccc(-c2ccc(C)cc2C(=O)OC)c1.O=C1CCC(=O)N1Br>>COC(=O)c1cccc(-c2ccc(CBr)cc2C(=O)OC)c1,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20130059853A1,COc1ccc(-c2ccc3c(c2)COC3=O)c(O)c1OC(F)F.OCC1(CBr)COC1>>COc1ccc(-c2ccc3c(c2)COC3=O)c(OCC2(CO)COC2)c1OC(F)F,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110275611A1,C[C@@H]1C[C@@H](N(C)C(=O)CC(C)(C)C)CN(c2cc(-c3ccc(C#N)c(F)c3)nc(N)n2)C1.NN>>C[C@@H]1C[C@@H](N(C)C(=O)CC(C)(C)C)CN(c2cc(-c3ccc4c(N)n[nH]c4c3)nc(N)n2)C1,,CCO,,O,,val
US20070049578A1,CCN(CC)S(F)(F)F.N#Cc1nccnc1N1CCN(C(=O)/C=C/c2cccc(Cl)c2)C(CO)C1>>N#Cc1nccnc1N1CCN(C(=O)/C=C/c2cccc(Cl)c2)C(CF)C1,,ClCCl,,,,val
US20100305066A1,CC1(C)CC(=O)c2sc(N3CCOCC3)c(-c3cccc(NC(=O)C(=O)O)c3)c2C1.CN(C)CCN>>CN(C)CCNC(=O)C(=O)Nc1cccc(-c2c(N3CCOCC3)sc3c2CC(C)(C)CC3=O)c1,,ClCCl,,CC(C)COC(=O)Cl,CCN(CC)CC,val
US09227995B2,CC#COC[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)OC.O=C(O)C(F)(F)F>>CC#COC[C@H](N)C(=O)NCC(=O)OC.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05364871,CC(=O)NCc1cc(Cl)cc(-c2csc(N=C(N)N)n2)n1>>CC(=O)NCc1cccc(-c2csc(N=C(N)N)n2)n1,[Pd],CO,,[H][H],,val
US06599890B1,COC(=O)[C@@H]1CCN(S(=O)(=O)c2ccc(OC)cc2)[C@@H](C(=O)OC(C)(C)C)C1>>COC(=O)[C@@H]1CCN(S(=O)(=O)c2ccc(OC)cc2)[C@@H](C(=O)O)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130085161A1,CC(=O)Cl.CC(C)(C)OC(=O)N1CC[C@@H](Nc2cc(F)ccc2[N+](=O)[O-])[C@H](O)C1>>CC(=O)O[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1Nc1cc(F)ccc1[N+](=O)[O-],,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040242573A1,CCN(CC)CC.OC1CCN(c2ccccc2Br)C1>>Brc1ccccc1N1CCC(N2CCOCC2)C1,,Cc1ccccc1,,CS(=O)(=O)Cl,,val
US04857507,CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(F)(F)CO>>O=C1N[C@@H](CC2CCCCC2)[C@H](C(F)(F)CO)O1,,CN(C)C=O,,[H-].[Na+],,val
US20050239826A1,C[C@]1(O)CCNC[C@H]1O.ClCc1cc2cc(C#Cc3ccc(-c4ccc(Cl)cc4)cn3)ccc2s1>>C[C@]1(O)CCN(Cc2cc3cc(C#Cc4ccc(-c5ccc(Cl)cc5)cn4)ccc3s2)C[C@H]1O,,CN(C)C=O,,,,val
US20100173933A1,ClCc1coc(-c2ccc(Cl)cc2)n1.NC(=O)c1c(F)ccc(O)c1F>>NC(=O)c1c(F)ccc(OCc2coc(-c3ccc(Cl)cc3)n2)c1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090270402A1,Fc1ccc(C#Cc2ccc(Cl)nn2)c(F)c1.NN>>NNc1ccc(C#Cc2ccc(F)cc2F)nn1,,C1COCCO1,,,,val
US04581356,CN1C(=O)CCc2ccccc21.O=C(Cl)CN1C(=O)c2ccccc2C1=O>>CN1C(=O)CCc2cc(C(=O)CN3C(=O)c4ccccc4C3=O)ccc21,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05302601,Cc1cc(C(=O)N(C2CCCCC2)C2CCCC2)ccc1C=O>>Cc1cc(C(=O)N(C2CCCCC2)C2CCCC2)ccc1CO,,CO,,[BH4-].[Na+],,val
US20100048502A1,CN(C)C(=O)Sc1ccc2ccc(C=O)nc2c1>>CN(C)C(=O)Sc1ccc2ccc(CO)nc2c1,,CCO,ClC(Cl)Cl,[BH4-].[Na+],,val
US20090291954A1,COS(C)(=O)=O.Nc1nnc(-c2cccc(Cl)c2Cl)c(N)n1>>Cn1nc(-c2cccc(Cl)c2Cl)c(N)nc1=N,,Cc1ccccc1,,CN(C)C=O,,val
US03996241,Cc1c(Cl)ccc2[nH]c(C(=O)O)cc12>>Cc1c(Cl)ccc2[nH]c(CO)cc12,,O,,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05075313,Nc1ccccc1.O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1C(=O)O>>O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccccc1,,C1CCOC1,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20110144068A1,C[Si](C)(C)CCOCn1cc(-c2ccncc2)c(-c2cccc(CNC(=O)c3ccc(C(F)(F)F)cc3)c2)n1>>O=C(NCc1cccc(-c2n[nH]cc2-c2ccncc2)c1)c1ccc(C(F)(F)F)cc1,,C1COCCO1,Cl,,,val
US05382590,CN(C(=O)CN(C(=O)CNC(=O)Nc1cccc(C=O)c1)c1ccccc1)c1ccccc1.NO>>CN(C(=O)CN(C(=O)CNC(=O)Nc1cccc(/C=N/O)c1)c1ccccc1)c1ccccc1,,CO,O,Cl,c1ccncc1,val
US04178449,CCc1[nH]nc(N)c1C#N.CN(C)C=CC(=O)c1ccccc1>>CCc1nn2c(-c3ccccc3)ccnc2c1C#N,,CC(=O)O,,,,val
US20060089367A1,COc1ccc(CN)cc1.O=C(O)c1ccc2c(c1)nc(COc1ccccc1)n2Cc1ccc(OC(F)(F)F)cc1>>COc1ccc(CNC(=O)c2ccc3c(c2)nc(COc2ccccc2)n3Cc2ccc(OC(F)(F)F)cc2)cc1,,C1CCOC1,,CC(C)N=C=NC(C)C,,val
US04551740,CC(=O)OC(C)=O.CN(C)c1ccc2nc3ccc(=O)cc-3sc2c1>>CC(=O)Oc1ccc2c(c1)Sc1cc(N(C)C)ccc1N2C(C)=O,[Zn],,,CCOC(C)=O,c1ccncc1,val
US20050191238A1,CC(C)(C)[Si](C)(C)Cl.CC(C)(C)c1ccc(C(O)CO)cc1>>CC(C)(C)c1ccc(C(O)CO[Si](C)(C)C(C)(C)C)cc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20140371199A1,C1COCCN1.CC(C)(C)[Si](C)(C)OCc1cc(Br)ccc1C(=O)O>>CC(C)(C)[Si](C)(C)OCc1cc(Br)ccc1C(=O)N1CCOCC1,,CN(C)C=O,O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05071999,CCOC(=O)N1CC2CCN(Cc3ccccc3)C2C1C>>CCOC(=O)N1CC2CCNC2C1C,[Pd],CCO,,,,val
US20150065480A1,CCOCCn1c(=O)c(C#N)c(NC2CN(C(=O)OC(C)(C)C)C2)c2ccccc21.Cl>>CCOCCn1c(=O)c(C#N)c(NC2CNC2)c2ccccc21.Cl,,C1COCCO1,,,,val
US20070161615A1,CS(=O)(=O)Cl.Cc1ncc(-c2nc(Nc3ccc(N4CC(O)C4)cc3)ncc2F)n1C(C)C>>Cc1ncc(-c2nc(Nc3ccc(N4CC(OS(C)(=O)=O)C4)cc3)ncc2F)n1C(C)C,,ClCCl,,CCN(CC)CC,,val
US20030018207A1,COCc1ccc(CC(=O)O)cc1>>COCc1ccc(CCO)cc1,,C1CCOC1,,,,val
US04595677,COC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(C)C(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)OCc1ccccc1>>COC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(C)C(=O)C[C@H](O)[C@@H](N)CC(C)C,,CO,,O=C=O,,val
US20090181942A1,COC(=O)C1CN(C(=O)CC[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3cccc32)C1>>COc1cccc([C@H]2O[C@H](CCC(=O)N3CC(C(=O)O)C3)c3cccn3-c3ccc(Cl)cc32)c1OC,,CO,,,,val
US20060089394A1,CCCCC(O)c1cccc(-c2ccc(C(F)(F)F)cc2)n1.COC(=O)Cc1ccc(O)cc1>>CCCCC(Oc1ccc(CC(=O)OC)cc1)c1cccc(-c2ccc(C(F)(F)F)cc2)n1,,C1CCOC1,,CCCCP(CCCC)CCCC,,val
US20160120841A1,COC(=O)c1ccc([C@H]2C[C@@H](NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c3ccc(OC)cc3O2)cc1>>COc1ccc2c(c1)O[C@@H](c1ccc(C(=O)O)cc1)C[C@H]2NC(=O)C1(c2ccc3c(c2)OC(F)(F)O3)CC1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20140378459A1,CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)Nc1ccc(C(=O)Oc2ccc(CC(=O)N[C@@H](Cc3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(=O)OC(C)(C)C)c(Cl)c2)cc1>>N=C(N)Nc1ccc(C(=O)Oc2ccc(CC(=O)N[C@@H](Cc3c[nH]cn3)C(=O)O)c(Cl)c2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110092473A1,C[C@]12CC[C@@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CCC2(SCc1ccccc1)SCc1ccccc1>>C[C@]12CC[C@@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)C(=S)CC[C@@H]12,,C1CCOC1,CCOCC,N,,val
US20110021537A1,COC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1>>CC(C)(C)OC(=O)CC[C@H](NC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1)C(=O)O,,C1CCOC1,,[Li+].[OH-],,val
US04224329,O=C1CCC(c2ccc(F)cc2)O1.[OH-]>>O=C(O)CCC(O)c1ccc(F)cc1,,O,,Cl,,val
US05712300,CC(C)CC1(C(C)C(=O)OC(C)(C)C)CCN(CCc2ccccc2)C1=O>>CC(C)CC1(C(C)C(=O)O)CCN(CCc2ccccc2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160083368A1,CCOC(=O)Cn1nc(C(N)=O)c2c1C(OCOC)[C@@H]1C[C@H]21>>CCOC(=O)Cn1nc(C#N)c2c1C(OCOC)[C@@H]1C[C@H]21,,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US07244735B2,CC(C)(C)OC(=O)N1CCNCC1.N[C@H](CO)c1cccc(Cl)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1CCN(C(=O)NC(CO)c2cccc(Cl)c2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110306542A1,CC(C)(C)OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1.CCCCCCCOc1ccc(C(=O)Cl)cc1>>CCCCCCCOc1ccc(C(=O)Oc2ccc(C[C@H](NC(=O)OCc3ccccc3)C(=O)OC(C)(C)C)cc2)cc1,,CC#N,ClCCl,,,val
US04435405,C[Si](C)(C)CCO.O=C(O)[C@@H]1C[C@H]1Sc1nc2ccccc2cc1-c1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>C[Si](C)(C)CCOC(=O)N[C@@H]1C[C@H]1Sc1nc2ccccc2cc1-c1ccccc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20110281832A1,CSc1c2c(=O)n(C)c(=O)n(CC(C)(C)C)c2nn1Cc1ccc(S(C)(=O)=O)cc1.OO>>Cn1c(=O)c2c(S(C)=O)n(Cc3ccc(S(C)(=O)=O)cc3)nc2n(CC(C)(C)C)c1=O,,CC#N,ClCCl,CC(=O)O,,val
US20070298104A1,CCCCOC(=O)c1[nH]c(=O)c2ccc(Oc3ccc(OCCC)cc3)cc2c1O.O=P(Br)(Br)Br>>CCCCOC(=O)c1nc(Br)c2ccc(Oc3ccc(OCCC)cc3)cc2c1O,,CCOC(C)=O,,Cc1ccccc1,,val
US04486428,C=O.CCCCSCCCc1cc(O)c2c(c1)NC(C)CC2CCO>>CCCCSCCCc1cc(O)c2c(c1)N(C)C(C)CC2CCO,,CC#N,,CC(=O)O,[BH3-]C#N.[Na+],val
US20090298807A1,CC(C)(C)[Si](C)(C)OCCc1ccc(C=O)s1>>CC(C)(C)[Si](C)(C)OCCc1ccc(CO)s1,,CCO,,[BH4-].[Na+],,val
US20110201609A1,Cc1ccccc1N.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>Cc1ccccc1NS(=O)(=O)c1ccc([N+](=O)[O-])cc1,,ClCCCl,,Cl,c1ccncc1,val
US20080027049A1,CC(C)C(=O)Cl.NC1CCc2oc3ccccc3c2C1>>CCCC(=O)Nc1ccc2oc3c(c2c1)CCCC3,,C1CCOC1,,CCN(CC)CC,,val
US20100016371A1,CCOC(=O)c1ccc(-n2cc(CC(C)C)c3ccc(Cl)cc32)s1>>CC(C)Cc1cn(-c2ccc(C(=O)O)s2)c2cc(Cl)ccc12,,CCO,,[Na+].[OH-],,val
US20100210680A1,CC(C)(C)OC(=O)N1C[C@@H]2OCc3c(C4CC4)cccc3[C@@H]2C1>>c1cc(C2CC2)c2c(c1)[C@@H]1CNC[C@@H]1OC2,,C1COCCO1,,CO,Cl,val
US20110281888A1,CCOc1ccc(F)c(Cl)c1.CN(C)C=O>>CCOc1ccc(F)c(Cl)c1C=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US06552068B1,CS(=O)(=O)Cl.OCCCCCC(F)(F)C(F)(F)F>>CS(=O)(=O)OCCCCCC(F)(F)C(F)(F)F,,ClCCl,,CCN(CC)CC,O,val
US05312936,CCCCCCC(C(=O)OCC)n1cnc([N+](=O)[O-])c1>>CCCCCCC(C(=O)OCC)n1cnc(N)c1,[Pd],,,[H][H],,val
US20040171654A1,O=[N+]([O-])c1ccc(Cl)cc1C(O)c1ccc(Cl)nc1>>O=C(c1ccc(Cl)nc1)c1cc(Cl)ccc1[N+](=O)[O-],,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20060189621A1,CS(=O)(=O)Cl.O=c1c(CO)cc(-c2ccc3c(c2)CCO3)nn1CC1CC1>>CS(=O)(=O)OCc1cc(-c2ccc3c(c2)CCO3)nn(CC2CC2)c1=O,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20050277645A1,COc1ccc2c(c1)CC(CC(=O)N1CCCC1)C2=O>>COc1ccc2c(c1)CC(CCN1CCCC1)C2O,,C1CCOC1,ClCCl,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06239151B1,CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)[C@H](N)CO)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1.Cc1ccc(S(=O)(=O)O)cc1>>CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)[C@H](N)CO)[C@H](C/C=C/c1ccccc1)C(=O)NO.Cc1ccc(S(=O)(=O)O)cc1,,CO,,,,val
US20150141455A1,CC(C)(C)OC(=O)N[C@]1(C)C[C@H]1c1ccccc1>>C[C@@]1(N)C[C@H]1c1ccccc1,,O,,C1COCCO1,Cl,val
US20100035874A1,C=O.CCCNCCC.CCc1oc2cc(C)nn2c1-c1ccc(Cl)cc1Cl>>CCCN(CCC)Cc1c(C)nn2c(-c3ccc(Cl)cc3Cl)c(CC)oc12,,CC(=O)O,,,,val
US20080039462A1,CN1CC=C(c2c[nH]c3ccc([N+](=O)[O-])cc23)CC1.O=S(=O)(Cl)c1ccccc1>>CN1CC=C(c2cn(S(=O)(=O)c3ccccc3)c3ccc([N+](=O)[O-])cc23)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20130196974A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1O>>CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1O,,ClC(Cl)Cl,,,,val
US20110046169A1,Cc1ccc(C(=O)O)c(=O)n1-c1ccc(F)cc1.Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)cc1Cl>>Cc1ccc(C(=O)Nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)cc2Cl)c(=O)n1-c1ccc(F)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040127576A1,C[C@]12CCC(=O)C(Cc3ccccc3)(Cc3ccccc3)[C@@H]1c1ccc(OCc3ccccc3)cc1CC2>>C[C@]12CCC(=O)C(Cc3ccccc3)(Cc3ccccc3)[C@@H]1c1ccc(O)cc1CC2,[Pd],CC(=O)O,,C1CCOC1,,val
US20030199542A1,CC(=O)N1CCc2c(c(-c3cccc(Cl)c3)nn2C)C1>>Cn1nc(-c2cccc(Cl)c2)c2c1CCNC2,,Cl,,O=C([O-])O.[Na+],,val
US04761420,CCOCN1C(C)=C(C(=O)O)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC)=C1C>>COC(=O)C1=C(C)NC(C)=C(C(=O)O)C1c1cccc([N+](=O)[O-])c1,,CC(C)=O,,Cl,,val
US20160024056A1,O=S(=O)(Cl)c1ccc(Cl)cc1.c1cc2c(ccn2CC2CCNCC2)cc1-c1cnn(C2CCCCO2)c1>>O=S(=O)(c1ccc(Cl)cc1)N1CCC(Cn2ccc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CC1,,ClCCl,O,CCN(CC)CC,CO,val
US20130210844A1,Cc1nc2c([N+](=O)[O-])cccc2c(=O)[nH]1.O=P(Cl)(Cl)Cl>>Cc1nc(Cl)c2cccc([N+](=O)[O-])c2n1,,Cc1ccccc1,,,,val
US20020123499A1,CS(=O)(=O)Cl.O=C(N1CCCC(CO)C1)C1(c2ccc(Cl)cc2)CCC1>>CS(=O)(=O)OCC1CCCN(C(=O)C2(c3ccc(Cl)cc3)CCC2)C1,,ClCCl,,CCN(CC)CC,,val
US05614517,COC(=O)/C=C/C1c2ccc(OC)cc2C(=O)N2CCc3ccccc3C12>>COC(=O)/C=C/c1c2n(c(=O)c3cc(OC)ccc13)CCc1ccccc1-2,,Cc1ccccc1,,,,val
US20110190341A1,CCC(N)[C@@]1(c2ccccc2)C[C@@H]2C[C@H]1CC2O.COc1nccc2cc(F)c(Cl)cc12>>CCC(N)[C@@]1(c2ccccc2)C[C@@H]2C[C@H]1CC2Oc1cc2ccnc(OC)c2cc1Cl,,CC(=O)N(C)C,,[H-].[Na+],,val
US20060258571A1,BrP(Br)Br.OCc1cc(I)ccc1OCc1ccccc1>>BrCc1cc(I)ccc1OCc1ccccc1,,Cc1ccccc1,,,,val
US20070149542A1,CCCN1CC=C(c2cccc(C(F)(F)F)c2F)CC1>>CCCN1CCC(c2cccc(C(F)(F)F)c2F)CC1,[Pd],CO,,Cl,,val
US20060167016A1,NCc1ccccc1.O=S(=O)(c1ccccc1)N1CC(CI)OC(CI)C1>>O=S(=O)(c1ccccc1)N1CC2CN(Cc3ccccc3)CC(C1)O2,,Cc1ccccc1C,,,,val
US20120064181A1,CC(C)(C)OC(=O)c1cnc(NN)c(Cl)c1.COC(=N)c1ccccn1>>CC(C)(C)OC(=O)c1cc(Cl)c2nnc(-c3ccccn3)n2c1,,CO,,Cl,,val
US20130190293A1,Cc1ccc2c(c1)c1c(n2-c2cccc(Br)c2)CCN(C)C1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>Cc1ccc2c(c1)c1c(n2-c2cccc(-c3cnn(C)c3)c2)CCN(C)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[K+].[K+],val
US20030087901A1,O=C(Cc1cccc(OCc2ccccc2)c1)Nc1cccc2ccccc12>>c1ccc(COc2cccc(CCNc3cccc4ccccc34)c2)cc1,,C1CCOC1,,,,val
US20070167442A1,CS(=O)(=O)c1ccc2c(c1)ncn2C1CCN(CCC(=O)c2ccccc2)CC1>>CS(=O)(=O)c1ccc2c(c1)ncn2C1CCN(CCC(O)c2ccccc2)CC1,,CCO,,[BH4-].[Na+],,val
US20120035196A1,CCOC(=O)CBr.Cc1cc(O)cc(C)c1-c1cccc(C=O)c1C>>CCOC(=O)COc1cc(C)c(-c2cccc(C=O)c2C)c(C)c1,,O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20130053384A1,CCCS(=O)(=O)N(c1cc(F)c(F)c(C(=O)c2ccc3ncc(Cl)nc3c2)c1F)S(=O)(=O)CCC.OB(O)c1ccccc1>>CCCS(=O)(=O)Nc1cc(F)c(F)c(C(=O)c2ccc3ncc(-c4ccccc4)nc3c2)c1F,,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20140094453A1,CC(C)CC(=O)N1CCC[C@H](CO)C1.N#Cc1c(N)cccc1F>>CC(C)CC(=O)N1CCC[C@H](COc2cccc(N)c2C#N)C1,,C1CCOC1,,[H-].[Na+],,val
US20100179320A1,COC(=O)Cc1ccccc1O.Clc1cc(Cl)ncn1.N#Cc1ccccc1O>>COC(=O)Cc1ccccc1Oc1cc(Oc2ccccc2C#N)ncn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080146606A1,CC(C)(C)N(CCNS(=O)(=O)c1ccc(-c2ccnc3[nH]c(C=O)cc23)cc1)C(=O)[O-].CCNCC>>CCN(CC)Cc1cc2c(-c3ccc(S(=O)(=O)NCCN)cc3)ccnc2[nH]1,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20060128752A1,COCCBr.Cc1cc(F)ccc1C1(CC(=O)N(C)Cc2cc(Cl)cc(Cl)c2)CCNCC1>>COCCN1CCC(CC(=O)N(C)Cc2cc(Cl)cc(Cl)c2)(c2ccc(F)cc2C)CC1,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20160237045A1,CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](C(=O)N[C@@H](Cc2ccc(-c3ccccc3C(=O)N3CCCCC3)cc2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)CC1.Cl>>Cl.NC[C@@H]1CC[C@@H](C(=O)N[C@@H](Cc2ccc(-c3ccccc3C(=O)N3CCCCC3)cc2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)CC1,,C1CCOC1,C1COCCO1,,,val
US20090099205A1,CONC(=O)Oc1ccccc1.C[C@H](CCNC(=O)OC(C)(C)C)N1CCC(NCC2CCCCC2)CC1>>CONC(=O)N(CC1CCCCC1)C1CCN([C@H](C)CCNC(=O)OC(C)(C)C)CC1,,C1CCOC1,,,,val
US06410534B1,CC(C)(C)OC(=O)Nc1cccc2ccc(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc12.Cl>>CC(C)(C)[Si](Oc1ccc2cccc(N)c2c1)(c1ccccc1)c1ccccc1.Cl,,CCOC(C)=O,,CCOCC,,val
US06096895,BrC(Br)(Br)Br.COc1nn(C)c(=O)n1-c1ccsc1CO>>COc1nn(C)c(=O)n1-c1ccsc1CBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20140171408A1,NC(N)=S.O=C(Nc1ccnc(Cl)c1F)c1c(Cl)cccc1[N+](=O)[O-]>>O=[N+]([O-])c1cccc(Cl)c1-c1nc2ccnc(Cl)c2s1,,CC(C)O,,CCN(CC)CC,c1ccncc1,val
US20070299103A1,CC1(C)OC[C@H](CON)O1.Cc1cc(I)ccc1Nc1cc2nnc(C)n2cc1C(=O)O>>Cc1cc(I)ccc1Nc1cc2nnc(C)n2cc1C(=O)NOC[C@H](O)CO,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20100240671A1,O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.OC1CCCC1>>O=C(Oc1ccc([N+](=O)[O-])cc1)OC1CCCC1,,ClCCl,,CCN(CC)CC,,val
US20160068489A1,Cc1nc(NC(=O)CC(C)CC(C)(C)C)c(C)c(C)c1OCc1ccccc1>>Cc1nc(NC(=O)CC(C)CC(C)(C)C)c(C)c(C)c1O,[Pd],,,CO,,val
US20100113410A1,COC(=O)Cc1cc2nn(Cc3ncc(C)c(OC)c3C)nc3c-2c1CSN=C3N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>COc1c(C)cnc(Cn2nc3cc(CC(=O)O)c4c-3c(n2)C(NC(=O)OC(C)(C)C)=NSC4)c1C,,CO,,Cl,[Na+].[OH-],val
US20070232583A1,Cc1cc(-c2ccc(Cl)cc2)nc(-c2ccnc(-c3cccc(S(=O)(=O)NC(C)(C)C)c3)c2)n1>>Cc1cc(-c2ccc(Cl)cc2)nc(-c2ccnc(-c3cccc(S(N)(=O)=O)c3)c2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090054399A1,COc1c2c(c3n(c1=O)CCCCN(CCN1CCOCC1)C3=O)CCN(Cc1ccc(F)c(Cl)c1)C2=O>>O=C1c2c(c3n(c(=O)c2O)CCCCN(CCN2CCOCC2)C3=O)CCN1Cc1ccc(F)c(Cl)c1,,C1COCCO1,CC(=O)O,Br,,val
US20120309673A1,CCOC(=O)NC(CC1(F)CCCC1)C(=O)NC1(C(O)C(=O)Nc2ccn(C(=O)OCC3c4ccccc4-c4ccccc43)n2)CCC1>>CCOC(=O)NC(CC1(F)CCCC1)C(=O)NC1(C(=O)C(=O)Nc2ccn(C(=O)OCC3c4ccccc4-c4ccccc43)n2)CCC1,,ClCCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20130055927A1,CCOC(C)=O.CCO[Si](CCCN=C=O)(OCC)OCC.Cc1cc(C)[nH]n1>>CCO[Si](CCCN=C=O)(OCC)OCC.[N-]=C=O,,CCOC(C)=O,,,,val
US20070265262A1,NC1CC1.O=C(O)Cc1ccc(Br)cc1>>O=C(Cc1ccc(Br)cc1)NC1CC1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20110306626A1,C=CCBr.CC(C)C1=NC2(CCCCCC2)NC1=O>>C=CCN1C(=O)C(C(C)C)=NC12CCCCCC2,,CN(C)C=O,,[H-].[Na+],,val
US04388317,CCOC(=O)C=Cc1ccc(CN(C)C)s1>>CCOC(=O)CCc1ccc(CN(C)C)s1,[Pd],CCO,,,,val
US20120149676A1,Cl.N#Cc1ccc(F)c([N+](=O)[O-])c1F>>Cl.NCc1ccc(F)c(N)c1F,[Pd],CO,,,,val
US07479536B1,BrC(Br)(Br)Br.CC(C)(C)OC(=O)NCCO>>CC(C)(C)OC(=O)NCCBr,,c1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20020082425A1,CC(C)CCN.Cc1ccccc1Cn1c(CCl)nc2ccccc21>>Cc1ccccc1Cn1c(CNCCC(C)C)nc2ccccc21,,CC#N,,,,val
US20090131444A1,COc1ccc2ncc(F)c(CC[C@H]3CC[C@H](N)CN3C(=O)OC(C)(C)C)c2n1.O=Cc1ccc2c(n1)NC(=O)CO2>>COc1ccc2ncc(F)c(CC[C@H]3CC[C@H](NCc4ccc5c(n4)NC(=O)CO5)CN3C(=O)OC(C)(C)C)c2n1,,CO,,[BH3-]C#N.[Na+],,val
US20130245254A1,CCN.O=C(CBr)Nc1ncc(Br)nc1Br>>CCN1CC(=O)Nc2ncc(Br)nc21,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20090275588A1,CCN.Cc1nc(CBr)co1>>CCNCc1coc(C)n1,,C1CCOC1,,,,val
US20080051419A1,CN(C)C=O.Cc1c[nH]c2ncnc(Cl)c12>>O=Cc1c[nH]c2ncnc(Cl)c12,,C1CCOC1,,[Li]CCCC,,val
US20100016343A1,Cl.O=C(NCCCCN1CCCCC1)Nc1ccc(-c2ccc(F)cc2)nc1>>Cl.O=C(NCCCCN1CCCCC1)Nc1ccc(-c2ccc(F)cc2)nc1,,ClCCl,,,,val
US20160046599A1,COC(=O)c1cc(C)cnc1-c1ncccn1>>Cc1cnc(-c2ncccn2)c(C(=O)O)c1,,CO,,[Na+].[OH-],,val
US20040037022A1,N[C@H](CO)Cc1ccc([N+](=O)[O-])cc1.O=Cc1ccccc1>>O=[N+]([O-])c1ccc(C[C@@H](CO)NCc2ccccc2)cc1,,ClCCl,,,,val
US20100240702A1,CCCC(CC(=O)OCC)n1c(=O)n(Cc2noc3ccccc23)c2ccccc21>>CCCC(CC(=O)O)n1c(=O)n(Cc2noc3ccccc23)c2ccccc21,,C1CCOC1,O,[Li+].[OH-],,val
US20120202856A1,Cc1oc(-c2nc3cc(-c4ccccc4F)cc(C(F)(F)F)c3[nH]2)nc1C(C)(C)C.Cl>>Cc1oc(-c2nc3cc(-c4ccccc4F)cc(C(F)(F)F)c3[nH]2)nc1C(C)(C)C.Cl,,CCOCC,,,,val
US04298538,CC=C1C[C@H]2[C@@H]3CCc4cc(OC)ccc4[C@H]3CC[C@]2(C)C1=O>>CC[C@H]1C[C@H]2[C@@H]3CCc4cc(OC)ccc4[C@H]3CC[C@]2(C)C1=O,[Pd],CCO,,,,val
US06380396B1,O=CC[C@H](Cn1ccnc1)c1ccc(Cl)c(Cl)c1>>OCC[C@H](Cn1ccnc1)c1ccc(Cl)c(Cl)c1,,CCO,O,Cl,[Na+].[OH-],val
US20090156610A1,COC(=O)c1ccc(O)c(Cl)c1.O=Cc1cc(Br)ccc1F>>COC(=O)c1ccc(Oc2ccc(Br)cc2C=O)c(Cl)c1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20110059957A1,CC(=O)N1CCN(c2ccc(CCc3ccc(C(=O)NNC(=O)OC(C)(C)C)s3)nc2)CC1>>CC(=O)N1CCN(c2ccc(CCc3ccc(C(=O)NN)s3)nc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100179316A1,COc1cc2c(cc1OC)CC(=O)N(CCCI)C=C2>>C1=CNc2ccccc2C=C1,,O,,O=C([O-])[O-].[K+].[K+],,val
US06924284B2,COc1ccc(-c2noc(CCC(=O)NCCN)n2)cc1.O=c1[nH]nc(CCl)c2ccccc12>>COc1ccc(-c2noc(CCC(=O)NCCNCc3n[nH]c(=O)c4ccccc34)n2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130317000A1,CO.O=C(O)c1cnc(OCC23CC4CC(CC(C4)C2)C3)c(Cl)c1>>COC(=O)c1cnc(OCC23CC4CC(CC(C4)C2)C3)c(Cl)c1,,ClCCl,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US20050124555A1,CCOc1ccc(C)cc1Br.O=C1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1>>CCOc1ccc(C)cc1C1(O)O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20080045561A1,CCO.COc1cc2c(nc1OC)c(-c1cc3c(C=NO)ccnc3n1S(=O)(=O)c1ccc(C)cc1)cn2C>>COc1cc2c(-c3cc4c(CN)ccnc4n3S(=O)(=O)c3ccc(C)cc3)cn(C)c2cc1OC,[Zn],CCO,O,O=CO,,val
US05428162,CC(C)(C)c1cc2c(c(C(C)(C)C)c1)OC(=O)C2c1ccc(O)cc1.OCCCl>>CC(C)(C)c1cc2c(c(C(C)(C)C)c1)OC(=O)C2c1ccc(OCCO)cc1,,[Na+],[OH-],Cl,,val
US20090253687A1,CC(C)(C)OC(=O)NN.COc1cccc(I)c1>>COc1cccc(N(N)C(=O)OC(C)(C)C)c1,,CN(C)C=O,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US04873236,CC(C)N(CC1CCCCN1CCN)C(C)C.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>CC(C)N(CC1CCCCN1CCNC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(C)C,,CC#N,,,,val
US04287201,ClC1=NCCN1.Nc1ccccc1Cl>>Clc1ccccc1N=C1NCCN1,,CO,O,O=S(=O)(O)O,[Na+].[OH-],val
US20050203081A1,CO.O=C(O)c1ncccc1S>>COC(=O)c1ncccc1S,Cl,CO,,[Na+].[OH-],,val
US20130129753A1,CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)N(C)C(=O)[C@@H](N)C(C)C.CN(C(=O)OC(C)(C)C)C(C)(C)C(=O)O>>CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)N(C)C(=O)[C@@H](NC(=O)C(C)(C)N(C)C(=O)OC(C)(C)C)C(C)C,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06248736B1,CI.O=C(NCc1ccc(Cl)cc1)c1cnc2ccc(CO)cc2c1O>>Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CO)ccc21,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US05329007,CC(N)C(O)c1ccccc1.Clc1nc(Cl)c2cnn(-c3ccccc3)c2n1>>CC(Nc1nc(Cl)nc2c1cnn2-c1ccccc1)C(O)c1ccccc1,,CCO,O,Cl,[K+].[OH-],val
US04755511,CC(=O)Nc1ccc2c(c1)CCC([N+](C)(C)C)C2=O.CO.[C-]#N>>CC(=O)Nc1ccc2c(c1)CCC(CC#N)C2=O,,O,,[I-].[K+],,val
US20020132796A1,CCOC(=O)c1ccc(C#Cc2ccc(C3(OCc4ccccc4)CC3)c(CC)c2)cc1>>CCc1cc(C#Cc2ccc(C(=O)O)cc2)ccc1C1(OCc2ccccc2)CC1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20100004239A1,CC(=O)OC(C)(C)C(=O)Cl.Nc1cc2c(cc1F)CC(=O)N2>>CC(=O)OC(C)(C)C(=O)Nc1cc2c(cc1F)CC(=O)N2,,C1CCOC1,,C1CCNCC1,,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCN3CCCC3)cc1CC2CC>>CCC1Cc2cc(OCCN3CCCC3)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21,,CO,O,[Li]O,,val
US20130052281A1,C[Si](C)(C)C#Cc1cc(OCc2ccccc2)c(OCc2ccccc2)nn1>>C#Cc1cc(OCc2ccccc2)c(OCc2ccccc2)nn1,,C1CCOC1,,CO,O=C([O-])[O-].[K+].[K+],val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(C)=O)CC2)c2ncnn12.C[Si](C)(C)C(F)(F)F>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(O)C(F)(F)F)CC2)c2ncnn12,,C1CCOC1,,Cl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US05889002,CC(N=C=S)c1ccccc1.Nc1cc(Cl)sc1S(N)(=O)=O>>C[C@H](NC1=NS(=O)(=O)c2sc(Cl)cc2N1)c1ccccc1,,CCOC(C)=O,,Cl,,val
US20140057912A1,COc1c(C(C)=O)cc(Cl)c(Cl)c1I>>COc1c(C(C)O)cc(Cl)c(Cl)c1I,,CO,,[BH4-].[Na+],,val
US20090099169A1,CCOC(C)=O.Clc1cc(CI)c2oc(C3CCCCC3)cc2c1.c1cn[nH]c1>>CCOC(=O)c1cc(C)n(Cc2cc(Cl)cc3cc(C4CCCCC4)oc23)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110118245A1,CC(C)(C)c1cc(NC(=O)Oc2ccccc2)n(-c2ccc(C#N)cc2)n1.COc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC>>COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(C#N)cc4)c3)c2cc1OC,CN(C)c1ccncc1,C1CCOC1,,,,val
US20030092720A1,C/C(=C\c1cnc2cc(CCc3nc(C(C)C)cs3)ccn2c1=O)C(=O)OC(C)(C)C>>C/C(=C\c1cnc2cc(CCc3nc(C(C)C)cs3)ccn2c1=O)C(=O)O,,O=C(O)C(F)(F)F,,,,val
US20050054696A1,Nc1ccccc1C(=O)NNC(=O)c1cc2cc(Cl)ccc2[nH]1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(Nn1c(=O)[nH]c2ccccc2c1=O)c1cc2cc(Cl)ccc2[nH]1,,ClC(Cl)Cl,O,C1CCOC1,O=C([O-])O.[Na+],val
US03980784,CCI.O=[N+]([O-])c1cc(C(F)(F)F)cc2c1nc(C(F)(F)F)n2O>>CCOn1c(C(F)(F)F)nc2c([N+](=O)[O-])cc(C(F)(F)F)cc21,,CO,,C,C[O-].[Na+],val
US20090105212A1,CN.COCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(CCl)cc3)c2n1>>CNCc1ccc(Cn2c(=O)[nH]c3c(N)nc(OCCOC)nc32)cc1,,CN(C)C=O,,,,val
US20100311749A1,Cc1ccc(Br)cc1N1CCNCC1=O.O=C(Cl)c1cccc(C(F)(F)F)c1Cl>>Cc1ccc(Br)cc1N1CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)CC1=O,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20060257987A1,CCc1ccc(OC(C)CCc2ccc(OCC(=O)O)c(C)c2)c(C(=O)c2ccccc2)c1.COC(=O)CCc1ccc(S)cc1C>>CCc1ccc(OC(C)CCSc2ccc(CCC(=O)OC)c(C)c2)c(C(=O)c2ccccc2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100216836A1,CCOC(=O)C1(C)CCCN(CC2COc3ccccc3O2)C1>>CC1(CO)CCCN(CC2COc3ccccc3O2)C1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20150329538A1,CC(C)(C)OC(=O)N1CC(Cc2ccccc2)c2[nH]c(-c3cccc4cccnc34)cc2C1=O>>O=C1NCC(Cc2ccccc2)c2[nH]c(-c3cccc4cccnc34)cc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050153970A1,CC(C)(C)OC(=O)N(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1N,[Pd],CO,,,,val
US20130158009A1,CS(=O)(=O)c1ccc(O[C@@H]2C(=O)N(C3CCNCC3)C[C@@H]2O)c(F)c1.Clc1cnc(Cl)cn1>>CS(=O)(=O)c1ccc(O[C@@H]2C(=O)N(C3CCN(c4cnc(Cl)cn4)CC3)C[C@@H]2O)c(F)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20100160369A1,CC(C)(C)OC(=O)C=Cc1cc(Cl)c(O)cc1Cl>>CC(C)(C)OC(=O)CCc1cc(Cl)c(O)cc1Cl,[Pd],CCO,,,,val
US05221676,N#Cc1cccc(C2CCN(Cc3ccccc3)C2)c1>>NCc1cccc(C2CCN(Cc3ccccc3)C2)c1,[Ni],CO,,N,,val
US20020072616A1,CCCCCCN1CC2C(C1)C2(C)c1ccc([N+](=O)[O-])c(NC(C)=O)c1>>CCCCCCN1CC2C(C1)C2(C)c1ccc([N+](=O)[O-])c(N)c1,,CO,O,[K+].[OH-],,val
US20080176904A1,BrC(Br)(Br)Br.CCOC(=O)c1cccc(-c2cccc(CO)c2)c1>>CCOC(=O)c1cccc(-c2cccc(CBr)c2)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20030229089A1,COc1ccc(CNc2nc(SC)ncc2C=O)cc1Cl.Cn1ccnc1>>COc1ccc(CNc2nc(SC)ncc2C(O)c2nccn2C)cc1Cl,,C1CCOC1,,[Li],,val
US20040023971A1,CC(C)(C)OC(=O)N1C2CCC1CNC2.COc1ccc(OC(CCCOS(C)(=O)=O)c2ccc(C#N)cc2)cc1OC>>COc1ccc(OC(CCCN2CC3CCC(C2)N3C(=O)OC(C)(C)C)c2ccc(C#N)cc2)cc1OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05164500,Nc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@H]3CO)c2n1.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O>>Nc1nc(=O)c2ncn([C@@H]3O[C@H](CO)[C@H]3CO)c2[nH]1,,O=P([O-])([O-])[O-],,,,val
US20110306587A1,CC(C)(C)OC(=O)N1CC(c2ncccc2Br)C1.Cl>>Brc1cccnc1C1CNC1.Cl,,CO,,,,val
US20070232591A1,NC1CCC1.O=C(O)c1ccc2cnccc2n1>>O=C(NC1CCC1)c1ccc2cnccc2n1,,ClCCl,,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,,val
US05312929,C=CCBr.CC1=C(c2ccccc2)C(=O)N(C(C)(C)C(=O)O)C1>>C=CCOC(=O)C(C)(C)N1CC(C)=C(c2ccccc2)C1=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160200708A1,CN.COCC(Br)C(OC)OC>>CNC(COC)C(OC)OC,,Cc1ccccc1,,,,val
US07019147B1,Clc1ccc2cccc(Br)c2n1.c1nc2cc3c(cc2[nH]1)OCCO3>>Brc1cccc2ccc(-n3cnc4cc5c(cc43)OCCO5)nc12,,CN1CCCC1=O,,[H-].[Na+],,val
US20140243302A1,COC(=O)c1ccc2c(n1)NC(=O)CS2>>O=C1CSc2ccc(CO)nc2N1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20090082393A1,CC(C)(C)OC(=O)CC[C@H](NC(=O)CCOc1no[n+]([O-])c1S(=O)(=O)c1ccccc1)C(=O)OC(C)(C)C>>O=C(O)CC[C@H](NC(=O)CCOc1no[n+]([O-])c1S(=O)(=O)c1ccccc1)C(=O)O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20050107339A1,COc1cc(OC)cc([Mg]Br)c1.COc1ccc(C=O)cc1[N+](=O)[O-]>>COc1cc(OC)cc(C(O)c2ccc(OC)c([N+](=O)[O-])c2)c1,,C1CCOC1,,II,[Mg],val
US20060094767A1,Cl.Clc1ccc(C2=CCNCC2)cc1>>Cl.Clc1ccc(C2CCNCC2)cc1,O=[Pt],CCO,,[H][H],,val
US20140128383A1,COC(=O)C(OC(C)(C)C)c1csc2ccccc12.O=C1CCC(=O)N1Br>>COC(=O)C(OC(C)(C)C)c1c(Br)sc2ccccc12,,CC#N,,O,,val
US20090215742A1,BrBr.CCN(CC)C(=O)c1ccccc1O[Si](C)(C)C(C)(C)C>>CCN(CC)C(=O)c1c(Br)cccc1O[Si](C)(C)C(C)(C)C,,C1CCOC1,,[Li]C(C)(C)C,,val
US20040204586A1,Fc1ccc(CBr)cc1.O=c1[nH]c2ccc(Cl)cc2c(=O)o1>>O=c1oc(=O)n(Cc2ccc(F)cc2)c2ccc(Cl)cc12,,CN(C)C=O,,[H-].[Na+],,val
US20120064181A1,CI.COC(=O)c1cc(-c2ccc(F)cc2)c2nc(CC(C)(C)O)[nH]c2c1>>COC(=O)c1cc(-c2ccc(F)cc2)c2nc(CC(C)(C)O)n(C)c2c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110118245A1,CC(C)(c1cc(NC(=O)Oc2ccccc2)no1)C(F)(F)F.CCOc1cc2c(Sc3cccc(N)c3)ncnc2cc1OC>>CCOc1cc2c(Sc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)ncnc2cc1OC,CN(C)c1ccncc1,C1CCOC1,,,,val
US04985585,CCCc1c(S)ccc(C(C)=O)c1OCCCC(=O)OCC.CCCc1c(SCCCBr)ccc(C(C)=O)c1O>>CCCc1c(SCCCSc2ccc(C(C)=O)c(OCCCC(=O)OCC)c2CCC)ccc(C(C)=O)c1O,,CC(C)=O,,[I-].[K+],,val
US20080004271A1,CSc1nc(Cl)c(C#N)c(-c2cccc([N+](=O)[O-])c2)n1.NC(=O)CS>>CSc1nc(SCC(N)=O)c(C#N)c(-c2cccc([N+](=O)[O-])c2)n1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20130085161A1,CC(=O)Cl.Nc1ccc(Cl)nc1F>>CC(=O)Nc1ccc(Cl)nc1F,,CC(=O)O,,O=C([O-])O.[Na+],,val
US20120196842A1,C1CNCCN1.CC(=O)O[C@H]1C[C@]2(O)[C@@H]3CC[C@@H]4C[C@@H](OC(=O)Oc5ccc([N+](=O)[O-])cc5)CC[C@]4(C)[C@H]3CC[C@]2(C)[C@H]1c1ccc(=O)oc1>>CC(=O)O[C@H]1C[C@]2(O)[C@@H]3CC[C@@H]4C[C@@H](OC(=O)N5CCNCC5)CC[C@]4(C)[C@H]3CC[C@]2(C)[C@H]1c1ccc(=O)oc1,,ClCCl,,,,val
US20100317582A1,COC(=O)c1ccc(OC2C=CC(OC(C)=O)C2)cc1>>COC(=O)c1ccc(O[C@@H]2C=C[C@@H](O)C2)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20060229286A1,Cn1ccc2cc(C(=O)O)ccc21>>CN1CCc2cc(C(=O)O)ccc21,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20120010207A1,N#Cc1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1.OO>>NC(=O)c1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US05780498,CCOC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)NC(=O)c1cc(C)cc(C)c1.CI>>CCOC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1,,CN(C)C=O,,O,[H-].[Na+],val
US20150239915A1,Brc1ccc2ccc3cccc4ccc1c2c34.Cl[Si](Cl)(Cl)Cl>>Cl[Si](Cl)(Cl)c1ccc2ccc3cccc4ccc1c2c34,,C1CCOC1,CCOCC,[Li]CCCC,,val
US20050267149A1,CCCCCCN(Cc1ccccc1)C(=O)Cc1ccc(O)c(OC)c1.COC(=O)c1ccccc1CBr>>CCCCCCN(Cc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2C(=O)OC)c(OC)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20070179165A1,COC(=O)OC.O=C(O)c1c(Cl)cccc1Cl>>COC(=O)c1c(Cl)cccc1Cl,,CCOC(C)=O,O,C1CCC2=NCCCN2CC1,,val
US20100152192A1,CC(C)CCOc1c(/C=C/c2nc3sccn3c2C(=O)O)cccc1OC(F)F.Nc1nc(C(F)(F)F)cs1>>CC(C)CCOc1c(/C=C/c2nc3sccn3c2C(=O)Nc2nc(C(F)(F)F)cs2)cccc1OC(F)F,CN(C)c1ccncc1,C1CCOC1,CN(C)C=O,CCN=C=NCCCN(C)C,Cl,val
US20140315888A1,Cc1nc2c(N3CC(N(C)C(=O)OC(C)(C)C)C3)nc3ncc(Cl)cc3n2n1>>CNC1CN(c2nc3ncc(Cl)cc3n3nc(C)nc23)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110144334A1,CC(C)C(=O)Cl.Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)Nc1ncc(Br)cn1>>Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)N(C(=O)C(C)C)c1ncc(Br)cn1,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,O,val
US20140155398A1,Clc1c[nH]c2ccncc12.O=C(Cl)OCc1ccccc1>>O=C(OCc1ccccc1)n1cc(Cl)c2cnccc21,,ClCCl,,CCN(CC)CC,,val
US05202335,CCOC(=O)CCC(=O)OCC.Cc1ccccc1C=O>>Cc1ccccc1/C=C(\CC(=O)O)C(=O)O,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20120046278A1,CC(c1ccc(F)cc1)c1nc2c(S(C)(=O)=O)nc(N)nc2s1.O=C(COc1ccc(Cl)cc1)N1CCNCC1>>CC(c1ccc(F)cc1)c1nc2c(N3CCN(C(=O)COc4ccc(Cl)cc4)CC3)nc(N)nc2s1,,C1COCCO1,,CCN(CC)CC,,val
US20150210682A1,CC[Mg]Br.COc1ccc(CC(=O)N(C)OC)cc1Br>>CCC(=O)Cc1ccc(OC)c(Br)c1,,C1CCOC1,,,,val
US20080255149A1,N#Cc1ccc2c(c1)CN(C(=O)[C@H](N)Cc1ccc(Cl)cc1Cl)C2>>NCc1ccc2c(c1)CN(C(=O)[C@H](N)Cc1ccc(Cl)cc1Cl)C2,Cl[Ni]Cl,CCO,ClCCl,[BH4-].[Na+],,val
US05461158,CC(C)(C=NCc1ccccc1)SCc1ccccc1.COC(=O)/C=C(\CBr)C(=O)OC>>C=C1C(=O)N(Cc2ccccc2)C(C(C)(C)SCc2ccccc2)C1C(=O)OC,[Zn],C1CCOC1,,Cl,[Cl-].[NH4+],val
US20140073620A1,NC(=O)C1(c2ccccc2CCc2nc(Cl)ncc2Cl)CC1.Nc1ccccc1>>NC(=O)C1(c2ccccc2CCc2nc(Nc3ccccc3)ncc2Cl)CC1,,C1COCCO1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05604229,CCCCc1ccc(CCCCC(COC(C)=O)(COC(C)=O)NC(C)=O)cc1>>CCCCc1ccc(CCCCC(N)(CO)CO)cc1,,CO,,[Na+].[OH-],,val
US20090143367A1,Cc1ccsc1B(O)O.Cc1nc(Br)n2c1c(C)nc1ccc(F)cc12>>Cc1ccsc1-c1nc(C)c2c(C)nc3ccc(F)cc3n12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20070010511A1,CCI.Cc1cccc2[nH]c(=O)[nH]c12>>CCn1c(=O)[nH]c2c(C)cccc21,,CN(C)C=O,,[H-].[Na+],,val
US20120329808A1,N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ncnc3c2CSC3)CC1.O=C(OO)c1cccc(Cl)c1>>N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ncnc3c2CS(=O)C3)CC1,,CO,ClCCl,,,val
US05594011,Fc1ccc(-c2cncc(C3CCCCN3)c2)cc1.O=C(O)/C=C/C(=O)O>>Fc1ccc(-c2cncc(C3CCCCN3)c2)cc1.O=C(O)/C=C/C(=O)O,,CO,,c1ccncc1,,val
US20040198712A1,COC(=O)CCCCCN.Cl>>COC(=O)CCCCCN.Cl,,C1COCCO1,,,,val
US20100305145A1,CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCc1nnnn1CCC#N>>C[C@H](C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCc1nnn[nH]1)C(=O)O,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US20030114453A1,CCOC(=O)NC(=O)C(=NNc1cc(Cl)c(C(C)(C)c2noc(-c3ccccc3C)n2)c(Cl)c1)C(=O)NC(=O)OCC>>CCOC(=O)NC(=O)c1nn(-c2cc(Cl)c(C(C)(C)c3noc(-c4ccccc4C)n3)c(Cl)c2)c(=O)[nH]c1=O,,CC(=O)O,,O,CC(=O)[O-].[Na+],val
US20080188528A1,BrC(c1ccccc1)c1ccccc1.COC(=O)c1c(OC)cc[nH]c1=O>>COC(=O)c1c(OC)ccn(C(c2ccccc2)c2ccccc2)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20130281434A1,COc1ccnc(-c2ccc3c(cnn3C)c2)n1>>Cn1ncc2cc(-c3nccc(O)n3)ccc21,,Cl,,[Na+].[OH-],,val
US06326386B1,COC(=O)CCCN(C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1)c1ccccc1F.O=C(O)C(F)(F)F>>COC(=O)CCCN(C(=O)c1cc(Cl)cc(OCCNc2ccncc2)c1)c1ccccc1F.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20020193382A1,Cl.O=C1CN(C(=O)OCc2ccccc2)C=CN1CC1(O)CCN(c2ccncc2)CC1>>Cl.O=C1CNCCN1CC1(O)CCN(c2ccncc2)CC1,[Pd],CCOC(C)=O,CO,,,val
US05155117,BrCc1ccc(Br)cn1.CCCCc1n[nH]c(CCCC)n1>>CCCCc1nc(CCCC)n(Cc2ccc(Br)cn2)n1,,CN(C)C=O,CO,[H][H],[H-].[Na+],val
US20100120714A1,CN.CON=C(C(N)=O)c1cc(-c2ccn(-c3cccc(C(F)(F)F)c3)n2)cc(C)c1C>>CNC(=O)C(=NOC)c1cc(-c2ccn(-c3cccc(C(F)(F)F)c3)n2)ccc1C,,C1CCOC1,,CCOCC,,val
US20110312937A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C1COCC2CC2(c2cc(N=C(c3ccccc3)c3ccccc3)ccc2F)N1>>Fc1ccc(N=C(c2ccccc2)c2ccccc2)cc1C12CC1COCC(=S)N2,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20060025433A1,CC(C)(C)OC(=O)NC1CCC(CNc2nc(Cl)ncc2F)CC1.NCc1ccccc1OC(F)(F)F>>N[C@@H]1CC[C@@H](CNc2nc(NCc3ccccc3OC(F)(F)F)ncc2F)CC1,,CCOC(C)=O,,Cl,,val
US20060264433A1,COCN(CCc1ccccc1)[Si](C)(C)C.O=C(/C=C/c1cc(F)c(F)cc1F)N1C(=O)OC[C@@H]1Cc1ccccc1>>O=C1OC[C@H](Cc2ccccc2)N1C(=O)[C@H]1CN(Cc2ccccc2)C[C@@H]1c1cc(F)c(F)cc1F,,ClCCl,,Cc1ccccc1,O=C(O)C(F)(F)F,val
US20080300242A1,CCc1cc(N)c(OC)cc1N1CCC(N2CCN(S(C)(=O)=O)CC2)CC1.O=C(Nc1c(F)cccc1F)c1cccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)c1>>CCc1cc(Nc2nccc(-c3c(-c4cccc(C(=O)Nc5c(F)cccc5F)c4)nc4ccccn34)n2)c(OC)cc1N1CCC(N2CCN(S(C)(=O)=O)CC2)CC1,,CC(C)O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070293516A1,BrCC1CC1.Nc1ncnc2[nH]nc(-c3ccc4ccccc4c3)c12>>Nc1ncnc2c1c(-c1ccc3ccccc3c1)nn2CC1CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05550134,CI.C[C@]12CCC(=O)N[C@@H]1CCc1cc(Sc3ccccc3)ccc12>>CN1C(=O)CC[C@]2(C)c3ccc(Sc4ccccc4)cc3CC[C@@H]12,,CCOC(C)=O,,CC(C)(C)O,CC(C)(C)[O-].[K+],val
US20100324088A1,CCC1=C(C(=O)[O-])C(=O)C2CCCC2N1Cc1ccc(-c2ccccc2)cc1>>O=C(O)c1cn(Cc2ccc(-c3ccccc3)cc2)c2c(c1=O)CCC2,,CCO,,Cl,[Na+].[OH-],val
US20140066425A1,CC(=O)Nc1cc(C(F)(F)F)c(Br)cc1F.N#C[Cu]>>CC(=O)Nc1cc(C(F)(F)F)c(C#N)cc1F,,CN(C)C=O,,CCOC(C)=O,,val
US20130231329A1,O=Cc1ccccc1.c1ccc2scnc2c1>>OC(c1ccccc1)c1nc2ccccc2s1,,C1CCOC1,,[Li]CCCC,,val
US20110105504A1,C=C(C)CC(O)(CN[C@@H](C)c1ccc(Br)cc1)c1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C=C(C)CC1(c2ccccc2)CN([C@@H](C)c2ccc(Br)cc2)C(=O)O1,,ClCCl,,CCN(CC)CC,,val
US20100179154A1,CC(C)(C)OC(=O)Nc1cc(-c2c(-c3ccc(Cl)cc3)nc3ccc(Cl)nn23)ccn1>>Nc1cc(-c2c(-c3ccc(Cl)cc3)nc3ccc(Cl)nn23)ccn1,,ClCCl,,Cl,,val
US20120208808A1,CCOC(=O)CNN.O=Cc1c(Cl)nc(Cl)nc1Cl>>CCOC(=O)Cn1ncc2c(Cl)nc(Cl)nc21,,CCN(CC)CC,,C1CCOC1,Cl,val
US05321046,CC(C)=CCCC(C)=CCCC(C)=CCS.COC(C)(C)OC.Cc1cc(S)cc(C)c1O>>CC(C)=CCCC(C)=CCCC(C)=CCSC(C)(C)Sc1cc(C)c(O)c(C)c1,,c1ccccc1,,CCOCC,FB(F)F,val
US04420477,C#CCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nnnn3CC(=NOC)C(=O)O)CS[C@H]12)c1csc(NC(=O)C(F)(F)F)n1>>C#CCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nnnn3CC(=NOC)C(=O)O)CS[C@H]12)c1csc(N)n1,,O,,Cl,CC(=O)[O-].[Na+],val
US20140113935A1,CNCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1ccco1>>CN(Cc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)c1ccco1,,C1CCOC1,,CCN(CC)CC,Cl,val
US05218098,O=Cc1occc1COC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O>>OCc1ccc(CO[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)o1,,CO,,[BH4-].[Na+],,val
US20040053908A1,COC(=O)c1cc2c(=O)cc[nH]c2o1.O=S(Cl)Cl>>COC(=O)c1cc2c(Cl)ccnc2o1,,CN(C)C=O,,,,val
US06472416B1,CC(C)(C)C(=O)COc1n[nH]c(-c2ccc(S(C)(=O)=O)cc2)c1-c1ccccc1.Cc1[nH]nc(OCC(=O)C(C)(C)C)c1-c1ccc(F)cc1>>CCn1nc(OCC(=O)C(C)(C)C)c(-c2ccccc2)c1-c1ccc(S(C)(=O)=O)cc1,,O,,,,val
US20120034270A1,COP(=O)(OC)C(=[N+]=[N-])C(C)=O.O=Cc1ccc(C(O)c2ccc(F)cc2)cc1>>C#Cc1ccc(C(O)c2ccc(F)cc2)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US05283241,CC(C)(CC(=O)N[C@@H]1CCc2ccccc2NC1=O)NC(=O)OC(C)(C)C.COC(=O)Nc1ccccc1-c1ccc(CBr)cc1>>COC(=O)Nc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)CC(C)(C)NC(=O)OC(C)(C)C)CCc3ccccc32)cc1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US04248891,CC(=NO)C12CCCC(C1)C1CCC2C1>>CC(N)C12CCCC(C1)C1CCC2C1,,CCO,O,Cl,[Na],val
US05232939,CCOC(=O)CC(=O)CCl.Cc1c(N)n[nH]c1-c1ccccc1>>CCOC(=O)Cc1cn2nc(-c3ccccc3)c(C)c2[nH]1,,CC#N,,,,val
US20130338140A1,CC(C)(C)[S@](=O)/N=C/c1ccc(OC(F)F)cc1.COC(C)=O>>COC(=O)C[C@@H](N[S@@](=O)C(C)(C)C)c1ccc(OC(F)F)cc1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US04802913,COC(=O)CSc1cccc(-c2ccccc2)c1.COC=O>>COC(=O)C(=CO)Sc1cccc(-c2ccccc2)c1,,CN(C)C=O,,O,[H-].[Na+],val
US20090247559A1,Cc1cc(Br)cc(C=O)c1O.NO>>Cc1cc(Br)cc(/C=N\O)c1O,,CCO,,,,val
US20080132549A1,CCn1c(CO)nc(C(C)C)c1Sc1cc(C#N)cc(C#N)c1.O=C=NC(=O)C(Cl)(Cl)Cl>>CCn1c(COC(N)=O)nc(C(C)C)c1Sc1cc(C#N)cc(C#N)c1,,C1CCOC1,,,,val
US20080207721A1,CCC(N)C(Oc1ccc2c(cnn2-c2ccccn2)c1)c1ccnc(OC)c1.O=S(=O)(Cl)C1CC1>>CCC(NS(=O)(=O)C1CC1)C(Oc1ccc2c(cnn2-c2ccccn2)c1)c1ccnc(OC)c1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,[Cl-].[NH4+],val
US20080058342A1,CC(=O)CCl.COc1cc2c(Oc3ccc4[nH]cc(C)c4c3)ncnc2cc1OCC1CCNCC1>>COc1cc2c(Oc3ccc4[nH]cc(C)c4c3)ncnc2cc1OCC1CCN(CC(C)=O)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04921867,COC(=O)CBr.Oc1cccnc1Br>>COC(=O)COc1cccnc1Br,,C1CCOC1,,O,[H-].[Na+],val
US04503062,CC(=O)NBr.Clc1ccc(C2=CCCc3cc(Cl)c(Cl)cc32)cc1.O>>OC1(c2ccc(Cl)cc2)c2cc(Cl)c(Cl)cc2CCC1Br,,CC(C)=O,,,,val
US20090131458A1,BrCC1CCOCC1.CCCC(C)(C)COc1nc(N)c2nc(OC)[nH]c2n1>>CCCC(C)(C)COc1nc(N)c2nc(OC)n(CC3CCOCC3)c2n1,,CCOC(C)=O,CN(C)C=O,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US04831055,COC(=O)c1ccc(OCCN)cc1.Cc1ccc(C(=O)O)cc1>>COC(=O)c1ccc(OCCNC(=O)c2ccc(C)cc2)cc1,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100179146A1,CCOC(=O)CCc1c(/C=C2\C(=O)Nc3ccccc32)[nH]c2c1C(=O)CCC2>>O=C(O)CCc1c(/C=C2\C(=O)Nc3ccccc32)[nH]c2c1C(=O)CCC2,,CCO,,Cl,[Na+].[OH-],val
US05025031,O=C=NS(=O)(=O)Cl.Oc1cccc(I)c1>>NS(=O)(=O)Oc1cccc(I)c1,,Cc1ccccc1,,c1ccccc1,,val
US20050009829A1,COC(=O)c1ccc(F)c([N+](=O)[O-])c1.NCc1cc(-c2ccc(Cl)s2)on1>>COC(=O)c1ccc(NCc2cc(-c3ccc(Cl)s3)on2)c([N+](=O)[O-])c1,,CN(C)C=O,,CCN(CC)CC,O,val
US20160060197A1,CCOC(=O)COc1c(C(C)C)cccc1C(C)C1CC1>>CC(C)c1cccc(C(C)C2CC2)c1OCCO,,CCO,,[BH4-].[Na+],,val
US20030191124A1,CCI.CCN(CC)CCc1c[nH]c2ccc(NS(=O)(=O)c3ccc4ccccc4c3)cc12>>CCN(CC)CCc1c[nH]c2ccc(N(CC)S(=O)(=O)c3ccc4ccccc4c3)cc12,,CS(C)=O,,O,CC(C)(C)[O-].[K+],val
US20100056530A1,O=C1c2ccccc2C(=O)N1CCc1csc(Nc2ncccc2OCc2ccccc2)n1>>NCCc1csc(Nc2ncccc2OCc2ccccc2)n1,,CO,,NN,O,val
US20040019113A1,NC1CCCCC1.O=C=Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NC1CCCCC1,,ClCCl,,,,val
US06083986,NC(=O)c1ccccc1.O=[N+]([O-])c1ccc2c(c1)C1OC1C2>>O=C(N[C@@H]1c2cc([N+](=O)[O-])ccc2C[C@H]1O)c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20080045561A1,CCCC[Sn](Cl)(CCCC)CCCC.Cc1ccc(S(=O)(=O)n2ccc3c(Cl)ccnc32)cc1>>CCCC[Sn](CCCC)(CCCC)c1cc2c(Cl)ccnc2n1S(=O)(=O)c1ccc(C)cc1,,C1CCOC1,CCOC(C)=O,O,CC(C)[N-]C(C)C.[Li+],val
US20110195980A1,CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccnc3cnc(-c4nc(Cl)ccc4[N+](=O)[O-])cc23)C1>>CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccnc3cnc(-c4nc(Cl)ccc4N)cc23)C1,[Fe],CC(=O)O,,,,val
US20120129852A1,CC(=O)Cl.N#Cc1c(Cl)cc(-c2ccc(N)cc2)nc1-c1ccc(Oc2ccccc2)cc1>>CC(=O)Nc1ccc(-c2cc(Cl)c(C#N)c(-c3ccc(Oc4ccccc4)cc3)n2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160052884A1,COc1cn(CC(=O)OC(C)(C)C)c(=O)cc1-c1cc(Cl)ccc1C#N.O=S(=O)(OCC(F)F)C(F)(F)F>>COc1cn(C(CC(F)F)C(=O)OC(C)(C)C)c(=O)cc1-c1cc(Cl)ccc1C#N,,C1CCOC1,,,,val
US20110002855A1,CC(C)(C)OC(=O)N1CCc2cn3nccc3nc2C1>>c1cc2nc3c(cn2n1)CCNC3,,C1COCCO1,Cl,,,val
US20040082607A1,CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2ccccc2F)c2cc(O)ccc2c1=O.NC(=O)CI>>CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2ccccc2F)c2cc(OCC(N)=O)ccc2c1=O,,CN(C)C=O,,C1CCC2=NCCCN2CC1,O,val
US05264439,CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)OC)c2ccccc2)cc1>>CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1,,CO,,[Na+].[OH-],,val
US20020032208A1,CN(CCO)C(=O)OC(C)(C)C.COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1O>>COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCN(C)C(=O)OC(C)(C)C,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030013720A1,CC(C)(C)OC(=O)N1CCC(CN)(c2ccc(I)cc2)CC1.CC(C)COC(=O)Cl>>CC(C)COC(=O)NCC1(c2ccc(I)cc2)CCN(C(=O)OC(C)(C)C)CC1,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US20070213364A1,COC(=O)CCc1ccc(OCc2ccc(CCl)cc2)cc1.FC(F)(F)c1ccc(-c2cc(/C=C/c3ccccc3)[nH]n2)cc1>>COC(=O)CCc1ccc(OCc2ccc(Cn3nc(-c4ccc(C(F)(F)F)cc4)cc3/C=C/c3ccccc3)cc2)cc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US05674886,O=[N+]([O-])c1ccc(CBr)cc1.O=[N+]([O-])c1ccc(Nn2cnnc2)cc1>>O=[N+]([O-])c1ccc(CN(c2ccc([N+](=O)[O-])cc2)n2cnnc2)cc1,,CCC(C)=O,,[I-].[Na+],,val
US06500863B1,O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)NCCN2CCOCC2)c1O>>Nc1ccc(Cl)c(S(=O)(=O)NCCN2CCOCC2)c1O,[Pd],,,[H][H],,val
US20080176898A1,CCOC(=O)c1ccc(OCCCc2ccc(OCc3ccc(OC(C)C)cc3)cc2)c(CC(=O)N[C@H]2CC[C@@H](C(=O)OC)C2)c1>>CC(C)Oc1ccc(COc2ccc(CCCOc3ccc(C(=O)O)cc3CC(=O)N[C@H]3CC[C@@H](C(=O)O)C3)cc2)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20130035332A1,COc1nc2ccc(Cl)nc2s1>>O=c1[nH]c2ccc(Cl)nc2s1,,O,,C1COCCO1,Cl,val
US20020198197A1,COc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(C#N)c2)cc1-n1cccc1>>COc1cc2c(cc1-n1cccc1)NC(=O)CC(c1cccc(C#N)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020107248A1,COc1cc2c(cc1F)C(=Cc1ccc(S(C)=O)cc1)C(C)=C2CC(=O)O.O=C(OO)c1cccc(Cl)c1>>COc1cc2c(cc1F)C(=Cc1ccc(S(C)(=O)=O)cc1)C(C)=C2CC(=O)O,,CC(C)=O,,,,val
US20100273764A1,COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(CO)cnc3Nc3ccc(OC)nc3)n2)cc1.CS(=O)(=O)Cl>>COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(COS(C)(=O)=O)cnc3Nc3ccc(OC)nc3)n2)cc1,,ClCCl,,CCN(CC)CC,O,val
US05296495,CC(C)(C)c1csc(-c2cc3cc(CO)ccc3o2)n1.O=S(Cl)Cl>>CC(C)(C)c1csc(-c2cc3cc(CCl)ccc3o2)n1,,ClCCl,,O=C([O-])O.[Na+],,val
US20150210722A1,CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)n(-c2cccc(CP(C)(C)=O)c2)n1.Nc1cc(C(=O)NCCN2CCOCC2)cc(C(F)(F)F)c1>>CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(C(=O)NCCN5CCOCC5)cc(C(F)(F)F)c4)n3)c3ccccc23)n(-c2cccc(CP(C)(C)=O)c2)n1,,C1CCOC1,CN(C)C=O,,,val
US05212320,COC(=O)c1cccc(CN2c3ccccc3CCc3ccccc32)c1>>O=C(O)c1cccc(CN2c3ccccc3CCc3ccccc32)c1,,C1COCCO1,CO,[Na+].[OH-],,val
US04211786,NN.O=C(O)C=CC(=O)c1ccccc1>>O=C(O)C1CC(c2ccccc2)=NN1,,CCO,,Cl,[K+].[OH-],val
US04540695,CC(=O)NC1(C(C)=O)CCc2c(O)c3c(c(O)c2C1)C(=O)c1ccccc1C3=O>>CC(=O)C1(N)CCc2c(O)c3c(c(O)c2C1)C(=O)c1ccccc1C3=O,,CC(=O)O,,Cl,,val
US20120238599A1,CC(=O)OC(C)=O.COC(=O)CC(=O)C(=NO)C(=O)OC>>COC(=O)CC(=O)C(NC(C)=O)C(=O)OC,[Pd],,,,,val
US20120202777A1,CCOC(=O)CS(C)(=O)=O.Fc1ccc(-c2ccc(CCI)cc2)cc1>>CCOC(=O)C(CCc1ccc(-c2ccc(F)cc2)cc1)S(C)(=O)=O,,CN(C)C=O,,Cl,[H-].[Na+],val
US04686217,CC(N)=CC(=O)OC1CCCC1.COC(=O)CC(=O)CF.O=Cc1cccc(Cl)c1Cl>>COC(=O)C1=C(CF)NC(C)=C(C(=O)OC2CCCC2)C1c1cccc(Cl)c1Cl,,CCOC(C)=O,,,,val
US05432164,CC(=O)OC[C@H]1O[C@@H](n2cnc3c(Cl)nc(N)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O.NN1CCCCC1>>CC(=O)OC[C@H]1O[C@@H](n2cnc3c(NN4CCCCC4)nc(N)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O,,C1COCCO1,,CCN(CC)CC,,val
US20070259871A1,COc1ccc(CN2C(=O)c3cccc(O)c3C2=O)c(OC)c1.ClCCCN1CCOCC1>>COc1ccc(CN2C(=O)c3cccc(OCCCN4CCOCC4)c3C2=O)c(OC)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20100113458A1,CN(C)CCN.COc1ccc(CN(c2cccc(C(=O)O)c2)c2cc(Cl)nn3c(C#N)cnc23)cc1>>COc1ccc(CN(c2cccc(C(=O)NCCN(C)C)c2)c2cc(Cl)nn3c(C#N)cnc23)cc1,,CN(C)C=O,,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,,val
US20060009495A1,CCOC(C)=NC(=O)c1ccc(F)cc1.NNc1ccc(S(N)(=O)=O)cn1>>Cc1nc(-c2ccc(F)cc2)n(-c2ccc(S(N)(=O)=O)cn2)n1,,CO,ClCCl,O,,val
US20050207972A1,CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1OC.CI>>CC[N+](C)(CC)CCNC(=O)c1ccc(NC(C)=O)cc1OC.[I-],,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05064862,Cc1cccc(C)c1NC(=O)c1ccc([N+](=O)[O-])cc1>>Cc1cccc(C)c1NC(=O)c1ccc(N)cc1,[Pd],CCO,,,,val
US20100121048A1,CC(C)N(C[C@@H]1CN(Cc2ccccc2)CCN1C(=O)OC(C)(C)C)C(=O)CCC(=O)O.CCN=C=NCCCN(C)C>>CC(C)N(C[C@@H]1CN(Cc2ccccc2)CCN1C(=O)OC(C)(C)C)C(=O)CCC(N)=O,,CN(C)C=O,,Cl,O=C([O-])O.[Na+],val
US20070027318A1,CCCNC(=O)Nc1ccc(Oc2ccnc3cc(O)c(OC)cc23)cc1Cl.OCCCBr>>CCCNC(=O)Nc1ccc(Oc2ccnc3cc(OCCCO)c(OC)cc23)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20020147343A1,CC(C)(C)OC(=O)NCCSc1cc(-c2ccc[nH]2)c2c3c(ccc(F)c13)NC2=O.O=C(OO)c1cccc(Cl)c1>>NCCS(=O)c1cc(-c2ccc[nH]2)c2c3c(ccc(F)c13)NC2=O,,C1CCOC1,,CCOC(C)=O,,val
US20070072847A1,CCOC(=O)COC1CCN(C2CCN(C(=O)[C@@H](Cc3cc(C)c(OCc4ccccc4)c(C)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1>>CCOC(=O)COC1CCN(C2CCN(C(=O)[C@@H](Cc3cc(C)c(O)c(C)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1,[Pd],CCO,,[H][H],,val
US20130129753A1,CC[C@H](C)[C@@H]([C@@H](CC(=O)OC(C)(C)C)OC)N(C)C(=O)[C@@H](NC(=O)[C@]1(C)CCCN1C)C(C)C>>CC[C@H](C)[C@@H]([C@@H](CC(=O)O)OC)N(C)C(=O)[C@@H](NC(=O)[C@]1(C)CCCN1C)C(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060058324A1,CS(=O)(=O)Cl.OC1CCC(O)CC1>>CS(=O)(=O)OC1CCC(O)CC1,,c1ccncc1,,,,val
US20110124634A1,CI.COc1c(C)cnc(Cc2c[nH]c3c(Cl)nc(N)nc23)c1C>>COc1c(C)cnc(Cc2cn(C)c3c(Cl)nc(N)nc23)c1C,,CN(C)C=O,,[H-].[Na+],,val
US05563295,C/C(=C/C(=O)O)C(F)(F)F>>CC(CC(=O)O)C(F)(F)F,,CO,,,,val
US20150183801A1,O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(Br)c1.OCC1CCCN1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](CO)C2)c(Br)c1,,CC(C)O,,CCN(C(C)C)C(C)C,Cl,val
US20150126490A1,CC(C)(C)OC(=O)N1CCC(c2ccc(N)nc2)C1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCC(c2cnc(N)c(Br)c2)C1,,CC#N,,,,val
US06380230B1,CC(C)(C)O.O=C(O)c1cc2cc(Cl)ccc2[nH]1>>CC(C)(C)OC(=O)c1cc2cc(Cl)ccc2[nH]1,,CN(C)C=O,,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20090029905A1,CC[C@@H](CO)Oc1cc(Oc2cnc(C(=O)OC)cn2)cc(C(=O)Nc2ccn(C)n2)c1>>CC[C@@H](CO)Oc1cc(Oc2cnc(C(=O)O)cn2)cc(C(=O)Nc2ccn(C)n2)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20140235611A1,COC(=O)C(C)(C)c1ccc(Oc2cc(NC(=O)N3CCC(O)(CC(C)C)CC3)cc(Oc3ccc(F)cc3)c2)cc1>>CC(C)CC1(O)CCN(C(=O)Nc2cc(Oc3ccc(F)cc3)cc(Oc3ccc(C(C)(C)C(=O)O)cc3)c2)CC1,,C1CCOC1,CO,[Na+].[OH-],,val
US20100286123A1,COC(Cl)Cl.COc1ccc(C)cc1O>>COc1cc(C=O)c(C)cc1O,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20150025065A1,CS(=O)(=NC(=O)C(F)(F)F)c1ccc(-c2ccc(Br)cc2)nc1>>CS(=N)(=O)c1ccc(-c2ccc(Br)cc2)nc1,,CO,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US05952266,O=C(O)CCSc1ccc(Br)cc1>>O=C1CCSc2ccc(Br)cc21,,O=S(=O)(O)O,,,,val
US20150018363A1,Cn1c(C2CC(=O)C2)nc2ccc(-n3ccc(OCc4ccc(F)cc4)cc3=O)cc21>>Cn1c(C2CC(O)C2)nc2ccc(-n3ccc(OCc4ccc(F)cc4)cc3=O)cc21,,C1CCOC1,CO,[BH4-].[Na+],,val
US20140020808A1,Nc1cccc(N)c1.O=C1C=CC(=O)O1>>Nc1cccc(NC(=O)/C=C\C(=O)O)c1,,C1CCOC1,,,,val
US20080275054A1,C1COCCN1.Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c1cnn2-c1ccc(Br)cc1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c1cnn2-c1ccc(N2CCOCC2)cc1,[Pd],C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20110105462A1,C1CNC1.Cc1ccc(S(=O)(=O)OCC2COc3ccc(F)cc3O2)cc1>>Fc1ccc2c(c1)OC(CN1CCC1)CO2,,CC#N,,,,val
US20050113580A1,Cc1ccc(N(OCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(c2ccccc2)c2ccccc2)C(=O)OC(C)(C)C)cc1>>Cc1ccc(NOCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(c2ccccc2)c2ccccc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20100076026A1,Clc1ccc(-n2nc3ccccc3c2Nc2cccc(Cl)c2)cc1.O=C=NC1CCCCC1>>O=C(NC1CCCCC1)N(c1cccc(Cl)c1)c1c2ccccc2nn1-c1ccc(Cl)cc1,,Cc1ccccc1,,,,val
US20110034507A1,CO.COc1ccc2c(c1)COC(=O)C2.O=S(Br)Br>>COC(=O)Cc1cc(OC)ccc1CBr,,ClCCl,,Cc1ccccc1,O=C([O-])O.[Na+],val
US20160264554A1,Cc1cc2ccccc2[nH]1.II>>Cc1[nH]c2ccccc2c1I,,CN(C)C=O,,O,[K+].[OH-],val
US20150025087A1,COc1ncc(Br)cc1C.N#C[Cu]>>COc1ncc(C#N)cc1C,,CCOC(C)=O,CN(C)C=O,,,val
US20130292665A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2ccc(-c3c4ccccc4c(-c4ccc(-c5ccccc5)c5ccccc45)c4ccccc34)cc2c1>>O=S(=O)(Oc1ccc2ccc(-c3c4ccccc4c(-c4ccc(-c5ccccc5)c5ccccc45)c4ccccc34)cc2c1)C(F)(F)F,,c1ccncc1,,,,val
US20150232435A1,CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.O=C(c1ccccc1)N1CCNCC1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCN(C(=O)c4ccccc4)CC3)CC2)cc(C(F)(F)F)n1,,CO,ClC(Cl)Cl,,,val
US20110053921A1,COC(=O)C1(C)COCCN1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>COC(=O)C1(C)COCCN1c1nc(Cl)ncc1[N+](=O)[O-],,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20030236252A1,NCCCc1ccccc1.O=C1CCC(c2ccc3[nH]c(=O)oc3c2)CC1>>O=c1[nH]c2ccc([C@@H]3CC[C@@H](NCCCc4ccccc4)CC3)cc2o1,,CC(C)O,,[BH4-].[Na+],,val
US20100125081A1,Cc1cc(C2(c3cccc(Br)c3)N=C(N)c3ncccc32)cc(C2CC2)c1OC(F)F>>Cc1cc(C2(c3ccccc3)N=C(N)c3ncccc32)cc(C2CC2)c1OC(F)F,[Pd],CO,,,,val
US20150051197A1,FC(F)(F)CBr.O=S1(=O)CCN2C(=N1)C1(c3ccc(O)cc3)CCC2CC1>>O=S1(=O)CCN2C(=N1)C1(c3ccc(OCC(F)(F)F)cc3)CCC2CC1,,CCOC(C)=O,O,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20090318441A1,CCC(CC)Nc1nc(Cl)ncc1C#CC(C)O>>CCC(CC)n1c(C(C)O)cc2cnc(Cl)nc21,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080227770A1,COC(=O)CCc1nc(C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)COC(C)=O)C2=O)sc1C>>COc1cccc([C@H]2O[C@H](Cc3nc(C(C)C(=O)O)c(C)s3)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,O,,CCO,[Na+].[OH-],val
US20150225400A1,Fc1ccc(-n2cccn2)cc1OCc1ccccc1>>Oc1cc(-n2cccn2)ccc1F,[Pd],CO,,,,val
US20090042945A1,CC(C)(C)CNc1noc2ccc(-c3cccc(CNC4CC4)c3)cc12.O=C(Cl)c1ccccc1>>CC(C)(C)CNc1noc2ccc(-c3cccc(CN(C(=O)c4ccccc4)C4CC4)c3)cc12,,ClCCl,,CCN(CC)CC,,val
US05093335,N.N#Cc1nc(Cl)c(Cl)nc1C#N>>N#Cc1nc(N)c(Cl)nc1C#N,,C1CCOC1,,O,,val
US20050272823A1,CCOC(=O)C(CC(C)(C)c1ccc(Cl)c(F)c1OC)(O[Si](C)(C)C)C(F)(F)F>>CCOC(=O)C(O)(CC(C)(C)c1ccc(Cl)c(F)c1OC)C(F)(F)F,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20030064912A1,O=C(CCC(CS(=O)Cc1ccccc1)C(=O)OCc1ccccc1)OCc1ccccc1>>O=C(O)CCC(CS(=O)Cc1ccccc1)C(=O)O,,C1CCOC1,,[Na+].[OH-],,val
US20070066820A1,c1ccc(COc2ccc(-c3cccnc3)cc2)cc1>>Oc1ccc(-c2cccnc2)cc1,[Pd],C1CCOC1,CCO,,,val
US20130336920A1,O=C(NCc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(OC3CCC3)ccc2[N+](=O)[O-])c1>>Nc1ccc(OC2CCC2)cc1-c1cc(C(=O)NCc2cccc(C(F)(F)F)c2)ccn1,[Pd],CO,,,,val
US20020111369A1,O=C(O)c1ccc(F)c(S(=O)(=O)N2CCOCC2)c1.[SH-]>>O=C(O)c1ccc(S)c(S(=O)(=O)N2CCOCC2)c1,,CN(C)C=O,,O,,val
US20160115146A1,COc1ccc2cc(C(=O)[O-])c(=O)oc2c1>>COc1ccc2cc(C(=O)O)c(=O)oc2c1,,C1CCOC1,O,[Li+].[OH-],,val
US04168385,COC(=O)C(Br)c1ccc(Oc2ccccc2)cc1.Oc1ccccc1>>COC(=O)C(Oc1ccccc1)c1ccc(Oc2ccccc2)cc1,,CO,,,,val
US20140329867A1,CC(C)c1ccc(O)cc1.O=[N+]([O-])c1ccc(Cl)nc1>>CC(C)c1ccc(Oc2ccc([N+](=O)[O-])cn2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100292212A1,CCCN.O=C(Cl)OC(Cl)(Cl)Cl.O=C1N(c2ccc(OC(F)(F)F)cc2)CCC12CCNCC2>>CCCNC(=O)N1CCC2(CC1)CCN(c1ccc(OC(F)(F)F)cc1)C2=O,,ClCCl,,CCN(CC)CC,,val
US07528404B2,C=C(C)C1=NCCO1.OCCS>>C=C(C)C1=NCCO1.OCCS,,Cc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20080153812A1,C#CCN1CCC(c2ccc(C(=O)OC)cc2)CC1.COc1cc(CCc2cc(N)[nH]n2)cc(OC)c1>>C#CCN1CCC(c2ccc(C(=O)Nc3cc(CCc4cc(OC)cc(OC)c4)n[nH]3)cc2)CC1,,Cc1ccccc1,,C[Al](C)C,,val
US20090029994A1,COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1.N#CBr>>COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN(C#N)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CCO,,O=C([O-])O.[Na+],,val
US04788206,CCCCC/C(=C\C=C\C(=O)O)c1ccc(OC)c(OC)c1.O=[N+]([O-])c1ccc(O)cc1>>CCCCC/C(=C\C=C\C(=O)Oc1ccc([N+](=O)[O-])cc1)c1ccc(OC)c(OC)c1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05574038,CC(C)(C)OC(=O)N1CC(=O)Nc2cccc(F)c21>>O=C1CNc2c(F)cccc2N1,,CO,,,,val
US05387747,N#Cc1ccccc1-c1ccc(Cc2c(O)nc3ncnn3c2COCc2ccccc2)cc1>>N#Cc1ccccc1-c1ccc(Cc2c(O)nc3ncnn3c2CO)cc1,[Pd],CC(=O)O,,,,val
US04115568,COC(=O)c1cc(C)sc1N.O=[N+]([O-])c1cc(F)ccc1F>>COC(=O)c1cc(C)sc1Nc1ccc(F)cc1[N+](=O)[O-],,CCO,,,,val
US20030144285A1,Cc1ccccc1I.N#CCCCN1CCCC1.O=C(O)C(F)(F)F>>Cc1ccccc1C(=O)CCCN1CCCC1,,CCOCC,ClCCl,CC#N,,val
US20150368269A1,CC(=O)O[C@@H](C(=O)Nc1ccc2c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc2c1C(N)=O)[C@H]1OCCN(c2ccn(-c3ccncc3)n2)C1=O>>CC(=O)OC(C=O)[C@H]1OCCN(c2ccn(-c3ccncc3)n2)C1=O,,CCN(CC)CC,,,,val
US20160244415A1,CC(C)COC(=O)Cl.Cc1c(Cn2c(=O)c(C(N)=NO)cn(-c3ccc(N4CCOC4=O)cc3)c2=O)cccc1C(F)(F)F>>Cc1c(Cn2c(=O)c(-c3noc(=O)[nH]3)cn(-c3ccc(N4CCOC4=O)cc3)c2=O)cccc1C(F)(F)F,,CN(C)C=O,O,c1ccncc1,,val
US20050032786A1,COC(=O)c1ccccc1S.Cc1ccc(Sc2cccc(C#N)n2)cc1>>Cc1ccc(Sc2cccc(-c3nc(=O)c4ccccc4s3)n2)cc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20150005329A1,O=C(O)c1cccc(S(F)(F)(F)(F)F)c1.O=[N+]([O-])O>>O=C(O)c1cc([N+](=O)[O-])cc(S(F)(F)(F)(F)F)c1,,O=S(=O)(O)O,,,,val
US20120094996A1,COc1ccc(-c2nn3c(-c4cnc(N5CCN(C(=O)OC(C)(C)C)CC5)c(C(F)(F)F)c4)cnc3s2)cc1OC.Cl>>COc1ccc(-c2nn3c(-c4cnc(N5CCNCC5)c(C(F)(F)F)c4)cnc3s2)cc1OC.Cl,,C1COCCO1,,,,val
US20150266865A1,C[C@@](N)(c1ccccc1F)[C@@H](F)[C@@H](O)CO.O=C(N=C=S)c1ccccc1>>C[C@@](NC(=S)NC(=O)c1ccccc1)(c1ccccc1F)[C@@H](F)[C@@H](O)CO,,ClCCl,,,,val
US05232945,O=C1OC[C@H](Cc2ccccc2)N1[C@H](Cc1ccc(OCc2ccccc2)cc1)Oc1ccccc1>>O=C1OC[C@H](Cc2ccccc2)N1[C@H](Cc1ccc(O)cc1)Oc1ccccc1,[Pd],CCOC(C)=O,,,,val
US20080039426A1,Br[Mg]C1CC1.CCOP(=O)(Cl)OCC>>CCOP(=O)(OCC)C1CC1,,C1CCOC1,,[Cl-].[NH4+],,val
US06329381B1,Nc1nc(SCC2OCCO2)nc2c1nc(O)n2Cc1ccccc1>>Nc1nc(SCC=O)nc2c1nc(O)n2Cc1ccccc1,,C1CCOC1,Cl,O=C([O-])O.[Na+],,val
US20110003820A1,CC(=O)c1cnnn1CCN(Cc1ccccc1)Cc1ccccc1>>CC1NCCn2nncc21,[Pd],CCO,,,,val
US20110190395A1,CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCO.CS(=O)(=O)Cl>>CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20100297113A1,CCCCCCCCC/C(=C\c1c(C)c(OC)c(OC)c(OC)c1OC)C(=O)O>>CCCCCCCCC/C(=C\C1=C(C)C(=O)C(OC)=C(OC)C1=O)C(=O)O,,CCOCC,,,,val
US20140066410A1,CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CNC(=O)OC(C)(C)C)cc2)cc1>>CC(C)(C)OC(=O)NCc1ccc(NS(=O)(=O)c2ccc(N)cc2)cc1,,CCO,,[Na+].[OH-],,val
US20100063066A1,II.O=[N+]([O-])c1cccc2[nH]ncc12>>O=[N+]([O-])c1cccc2[nH]nc(I)c12,,CN(C)C=O,,[K+].[OH-],,val
US20100029710A1,CCc1nc2c(C)cc(C#Cc3cccnc3)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21>>CCc1nc2c(C)cc(CCc3cccnc3)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21,[Pd],C1CCOC1,CO,,,val
US20070270438A1,CCOC(=O)c1cnc(-c2noc(-c3ccc(CC(C)C)cc3)n2)cn1>>CC(C)Cc1ccc(-c2nc(-c3cnc(CO)cn3)no2)cc1,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20030195352A1,CCOC(=O)COc1ccc(Br)cc1C=O>>CCOC(=O)COc1ccc(Br)cc1CO,,CCO,,Cl,[BH4-].[Na+],val
US20140179715A1,CN1CCn2c1cc(Cl)nc2=O.N#Cc1cc(CO)ccc1Oc1ccc(C#N)c(C(F)(F)F)c1>>CN1CCn2c1cc(OCc1ccc(Oc3ccc(C#N)c(C(F)(F)F)c3)c(C#N)c1)nc2=O,,C1CCOC1,,[H-].[Na+],,val
US20090306089A1,CC(C)(C)OC(=O)NC1CCNCC1.CS(=O)(=O)OC[C@@H]1Cn2c(=O)cnc3ccc(=O)n1c32>>CC(C)(C)OC(=O)NC1CCN(C[C@@H]2Cn3c(=O)cnc4ccc(=O)n2c43)CC1,,CC#N,,c1ccncc1,,val
US20060009453A1,CN(C)CC(C)(C)c1ccc(C(F)(F)F)cc1[N+](=O)[O-]>>CN(C)CC(C)(C)c1ccc(C(F)(F)F)cc1N,[Pd],CO,,CCOC(C)=O,[H][H],val
US20030149277A1,CN.O=C(Cl)c1ccc(-c2nc(-c3ccc4c(c3)OCO4)c(-c3ccccn3)[nH]2)cc1>>CNC(=O)c1ccc(-c2nc(-c3ccc4c(c3)OCO4)c(-c3ccccn3)[nH]2)cc1,,C1CCOC1,O,Cl,,val
US20150093372A1,COCOc1cc(Oc2ccc(S(=O)(=O)CC3CS3)cc2)ccc1NC(=O)OC(C)(C)C>>Nc1ccc(Oc2ccc(S(=O)(=O)CC3CS3)cc2)cc1O,Cl,CO,,,,val
US04267176,CCOC(=O)C(=O)c1cccc(NC=O)n1.NO>>O=CNc1cccc(C(=NO)C(=O)O)n1,,CCO,,Cl,[Na+].[OH-],val
US20070099990A1,Cc1cc(C)c(C)c(O)c1.O=C(O)C(O)c1ccccc1>>Cc1cc(C)c2c(c1C)OC(=O)C2c1ccccc1,,CCCCCC,CCOC(C)=O,,,val
US20060063805A1,CCNc1ccc(O)cc1.O=C1CSC(=S)N1>>O=C1CSC(NCCc2ccc(O)cc2)=N1,,CCO,,CCN(C(C)C)C(C)C,,val
US20070004758A1,CC(C)c1nn(-c2ccnc(S(C)(=O)=O)n2)c(-c2cccc(C(F)(F)F)c2)c1Br.CO>>COc1nccc(-n2nc(C(C)C)c(Br)c2-c2cccc(C(F)(F)F)c2)n1,,CO,,C[O-].[Na+],,val
US20150291549A1,COc1cc(OCc2cccc(-c3ccc4c(c3)OCCO4)c2C)cc(O)c1C=O.N#Cc1cccc(CBr)c1>>COc1cc(OCc2cccc(-c3ccc4c(c3)OCCO4)c2C)cc(OCc2cccc(C#N)c2)c1C=O,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20020173519A1,CCOC(=O)c1c(O)c2c(OC)cccc2n(C)c1=O>>COc1cccc2c1c(O)c(C(=O)O)c(=O)n2C,,CC(=O)OC(C)=O,,Cl,,val
US20080293770A1,COc1cc(NC2CCN(C(=O)OC(C)(C)C)CC2)c(N)cc1Cl.O=C(Cl)Cl>>COc1cc2c(cc1Cl)[nH]c(=O)n2C1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CCN(CC)CC,,val
US20130210796A1,CC(C)I.CC1C(=O)NCCN1Cc1nnnn1-c1cccc(C(F)(F)F)c1>>CC1C(=O)N(C(C)C)CCN1Cc1nnnn1-c1cccc(C(F)(F)F)c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20060189663A1,COc1ccc(NC2=C(c3ccccc3)C(=O)N(Cc3ccccc3)C2=O)cc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COc1ccc(NC2=C(c3ccccc3)C(=O)N(Cc3ccccc3)C2=S)cc1,,Cc1ccccc1,,,,val
US04179452,CC(C)C(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C>>CC(C)C(O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C,,CO,,[BH4-].[Na+],,val
US20040133008A1,CC(=O)N1CCc2cc(NC(=O)c3ccc(C)nc3N3CCC(C)CC3)ccc21>>Cc1ccc(C(=O)Nc2ccc3c(c2)CCN3)c(N2CCC(C)CC2)n1,,C1CCOC1,CO,Cl,,val
US20120101103A1,COC(=O)C1CCOc2cc(Oc3ccc(C(=O)Nc4ccc(C(F)(F)F)nc4)cc3C)c(C#N)cc21>>Cc1cc(C(=O)Nc2ccc(C(F)(F)F)nc2)ccc1Oc1cc2c(cc1C#N)C(C(=O)O)CCO2,,C1CCOC1,,O,[Li]O,val
US04187315,CCCCCCCCNC(=O)C(=O)OCC>>CCCCCCCCNC(=O)C(=O)O,,CO,,[Na+].[OH-],,val
US05624943,COC(=O)CCc1ncccc1O.COc1ccc(/C=C/CCCCBr)cc1>>COC(=O)CCc1ncccc1OCCCC/C=C/c1ccc(OC)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140200227A1,C[C@H]1CNC[C@@H](NC(=O)OC(C)(C)C)C1(C)O.O=[N+]([O-])c1cnc2c(c1Cl)CCC2>>C[C@H]1CN(c2c([N+](=O)[O-])cnc3c2CCC3)C[C@@H](NC(=O)OC(C)(C)C)C1(C)O,,CC(C)O,,CCN(CC)CC,,val
US20110294788A1,CC(C)(C)N.O=S(=O)(Cl)c1ccc(Cl)nc1>>CC(C)(C)NS(=O)(=O)c1ccc(Cl)nc1,,ClCCl,,,,val
US20110046132A1,CCOC(=O)c1cnn(-c2nc3cc(S(=O)(=O)c4ccc(Cl)cc4)c(Cl)cc3n2COCCOC)c1>>CCOC(=O)c1cnn(-c2nc3cc(S(=O)(=O)c4ccc(Cl)cc4)c(Cl)cc3[nH]2)c1,,C1COCCO1,,CCO,Cl,val
US20030096816A1,CC(=O)CCl.CI.Cc1ccc(C(=O)CC#N)cc1.S=C=S>>CSc1sc(C(C)=O)c(-c2ccc(C)cc2)c1C#N,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120232081A1,BrC1C=CCCC1.Cc1ccccn1>>C1=CC(Cc2ccccn2)CCC1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20040127426A1,CCOC(=O)C(CC(CC)CC)(NC(=O)OCc1ccccc1)C(=O)OCC>>CCOC(=O)C(CC(CC)CC)(NC(=O)OCc1ccccc1)C(=O)O,,CCO,O,Cl,[Na+].[OH-],val
US04294842,NC(CSc1ccc(Cl)cc1)=NO.O=C(Cl)CCl>>ClCc1nc(CSc2ccc(Cl)cc2)no1,,Cc1ccccc1,,,,val
US05237063,CN.Fc1nc(F)c(OC(F)F)c(Cl)n1>>CNc1nc(F)c(OC(F)F)c(Cl)n1,,C1CCOC1,,,,val
US20070232663A1,COc1ccc(COc2c(-c3c[nH]c4c(CC=C(C)C)cccc34)n(C)c(CO)cc2=O)cc1>>CC(C)=CCc1cccc2c(-c3c(O)c(=O)cc(CO)n3C)c[nH]c12,,ClCCl,O,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20040082607A1,CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)C)c(=O)c2ccc(-c3nc(C)c(C(=O)O)s3)cc12.Cl>>CCCCOc1c(CN)n(CC(C)C)c(=O)c2ccc(-c3nc(C)c(C(=O)O)s3)cc12.Cl,,CCOC(C)=O,,,,val
US20050239797A1,CC(C)(C)OC(=O)N1CCNCC1.O=S(=O)(Oc1nccc2cc3c(cc12)N(Cc1ccccc1)CC3)C(F)(F)F>>CC(C)(C)OC(=O)N1CCN(c2nccc3cc4c(cc23)N(Cc2ccccc2)CC4)CC1,,CN(C)C=O,,,,val
US20040077669A1,CC#CCO.Clc1ncnc(Cl)c1Cl>>CC#CCOc1ncnc(Cl)c1Cl,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20100298301A1,C1CCNCC1.NC(=O)c1nc(-c2c(F)cccc2F)oc1-c1ccc(OCC2CO2)cc1>>NC(=O)c1nc(-c2c(F)cccc2F)oc1-c1ccc(OCC(O)CN2CCCCC2)cc1,,CO,,,,val
US04891057,BrBr.CCOC(=O)c1ccnn1-c1c(Cl)cccc1Cl>>CCOC(=O)c1c(Br)cnn1-c1c(Cl)cccc1Cl,,CC(=O)O,,O,,val
US20110130415A1,FCCBr.O=c1[nH]nnn1-c1cc([N+](=O)[O-])ccc1F>>O=c1n(CCF)nnn1-c1cc([N+](=O)[O-])ccc1F,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04375475,BrCCCCc1ccccc1.[C-]#N>>N#CCCCc1ccccc1,,CCO,,O,,val
US20140349990A1,COc1ccc(Cn2nc(C(=O)O)c(C(Nc3cc(Cl)c(=O)n(C)c3)c3ccc(Cl)cc3)c2C)cc1>>COc1ccc(Cn2nc3c(c2C)C(c2ccc(Cl)cc2)N(c2cc(Cl)c(=O)n(C)c2)C3=O)cc1,,CO,ClCCl,,,val
US20060106014A1,CC(=O)Oc1c(C)cc2c(c1C)CCC(C)(C)O2.O=[N+]([O-])O>>CC(=O)Oc1c(C)c2c(c([N+](=O)[O-])c1C)OC(C)(C)CC2,,CC(=O)O,,,,val
US05948753,CCCCCOC1(c2ccc(-c3ccc(C(=O)O)cc3)cc2)C=CC=CC1.Oc1c(F)c(F)c(F)c(F)c1F>>CCCCCOC1(c2ccc(-c3ccc(C(=O)Oc4c(F)c(F)c(F)c(F)c4F)cc3)cc2)C=CC=CC1,,CCOC(C)=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04762850,COC(=O)c1cnc(S)n1Cc1cc(F)cc(F)c1>>O=C(O)c1cnc(S)n1Cc1cc(F)cc(F)c1,,O,,Cl,[Na+].[OH-],val
US06632814B1,CC(=O)N1CCOc2cc(Br)ccc21>>Brc1ccc2c(c1)OCCN2,,CO,,[Na+].[OH-],,val
US20100087456A1,Cc1nc(N)nc(Cl)c1I.NC1CCOCC1>>Cc1nc(N)nc(NC2CCOCC2)c1I,,CCO,O,CCN(CC)CC,Cl,val
US20080064719A1,Cc1cc(OCc2ccccc2)c2c(n1)c(-c1ccc(-n3cccn3)cc1C)nn2C>>Cc1cc(O)c2c(n1)c(-c1ccc(-n3cccn3)cc1C)nn2C,[Pd],,,[H][H],,val
US20030055250A1,COc1c(F)cccc1CO.O=S(Cl)Cl>>COc1c(F)cccc1CCl,,ClCCl,,,,val
US03941802,NN.Nc1ccc(Cl)cc1C(=O)c1c(F)cccc1F>>NN=C(c1cc(Cl)ccc1N)c1c(F)cccc1F,,OCCOCCO,,O,,val
US20100056515A1,CC[Mg]Br.Cn1c(=O)n(C)c2c(C#N)ccc(Cl)c21.O=C([O-])O>>CCC(=O)c1ccc(Cl)c2[nH]c(=O)n(C)c12,,C1CCOC1,,Cl,,val
US20020183375A1,Cc1cc(C)c(-n2c3ncccc3n3c(CO)c(C)nc23)c(C)c1.O=S(Cl)Cl>>Cc1cc(C)c(-n2c3ncccc3n3c(CCl)c(C)nc23)c(C)c1,,ClCCl,,,,val
US05194446,CNS(=O)(=O)Cl.OCCOc1ccc(Cl)cc1>>NS(=O)(=O)OCCOc1ccc(Cl)cc1,,ClCCl,,c1ccncc1,,val
US07446127B2,C=CC(=O)OC(C)(C)C.O=Cc1ccc(OCc2ccccc2)cc1O>>CC(C)(C)OC(=O)C1=Cc2ccc(OCc3ccccc3)cc2OC1,,CN1CCCC1=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120172599A1,CC1=C(C#N)C(=C(C#N)C#N)OC1(C)C.CCCCN(CCCC)c1ccc(C=CC=O)c(OC)c1>>CCCCN(CCCC)c1ccc(C=CC=CC2=C(C#N)C(=C(C#N)C#N)OC2(C)C)c(OC)c1,,CCO,,C,O=C[O-].[NH4+],val
US20090186879A1,COC(=O)c1ccc(Cl)c2nc(Nc3c(C)nc(OC)nc3C)n(CCCCl)c12>>COC(=O)c1ccc(Cl)c2nc3n(c12)CCCN3c1c(C)nc(OC)nc1C,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20150087630A1,CCN.COC(=O)c1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCCCC4)cc3)cc12>>CCNC(=O)c1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCCCC4)cc3)cc12,,C1CCOC1,,,,val
US04312876,CC(=O)Cl.CN1CC[C@@H](Oc2ccc(O)cc2)[C@H](c2ccccc2)C1>>CC(=O)Oc1ccc(O[C@@H]2CCN(C)C[C@H]2c2ccccc2)cc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20010016579A1,C1CCNCCNC1.Cc1cc(C)c2oc(S)nc2c1>>Cc1cc(C)c2oc(N3CCCCNCC3)nc2c1,,Cc1ccccc1,,,,val
US20040132727A1,COc1cc2ncnc(Oc3ccc(N)c([N+](=O)[O-])c3)c2cc1OC.NC1CCN(CC2CCCCC2)C1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)NC4CCN(CC5CCCCC5)C4)c([N+](=O)[O-])c3)c2cc1OC,,CCN(CC)CC,ClC(Cl)Cl,O=C([O-])O.[Na+],,val
US20080161290A1,CN(C)C1CCNC1.O=C(O)c1cccnc1F>>CN(C)C1CCN(c2ncccc2C(=O)O)C1,,c1ccncc1,,C1CCC2=NCCCN2CC1,,val
US20160102088A1,Clc1cc2c(cn1)CNCC2.O=C(Cl)c1cccnc1>>O=C(c1cccnc1)N1CCc2cc(Cl)ncc2C1,,C1CCOC1,,CCN(CC)CC,,val
US20120289526A1,COc1cc(O)ccc1C.O=[N+]([O-])c1ccc(Cl)nc1>>COc1cc(Oc2ccc([N+](=O)[O-])cn2)ccc1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090163586A1,NS(=O)(=O)c1ccccc1NS(=O)(=O)/C=C/c1ccccc1-c1ccc2cccc-2o1>>NS(=O)(=O)c1ccccc1NS(=O)(=O)CCc1ccccc1-c1ccc2cccc-2o1,[Pd],CCOC(C)=O,,[H][H],,val
US20050065099A1,CC(C)=CCc1cc(O)c(C)c(C)c1O>>Cc1c(O)cc2c(c1C)OC(C)(C)CC2,,C1COCCO1,,CCOCC,FB(F)F,val
US20010051620A1,N#Cc1cnc2cc3[nH]cnc3cc2c1N(C=O)c1ccc(Oc2ccccc2)cc1>>N#Cc1cnc2c(c1Nc1ccc(Oc3ccccc3)cc1)C=C1N=CN=C1C2,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20030114508A1,CC(=O)NC1=C(Cl)C(=O)c2ccccc2C1=O.COCCN>>COCCNC1=C(NC(C)=O)C(=O)c2ccccc2C1=O,,c1ccccc1,,O,,val
US04931457,O=[N+]([O-])c1cc[n+]([O-])cc1F.Oc1ccc2cc(Br)ccc2c1>>O=[N+]([O-])c1cc[n+]([O-])cc1Oc1ccc2cc(Br)ccc2c1,,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20120015941A1,CON(C)C(=O)c1csc(NC(=O)NCc2ccc(Cl)c(Cl)c2)n1>>O=Cc1csc(NC(=O)NCc2ccc(Cl)c(Cl)c2)n1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030232850A1,Fc1ccc(CBr)cc1.O=C(OCc1ccccc1)N1CCc2c([nH]c3ccccc23)C1>>O=C(OCc1ccccc1)N1CCc2c(n(Cc3ccc(F)cc3)c3ccccc23)C1,,CN(C)C=O,,O,[H-].[Na+],val
US20150218187A1,O=C1CC2(CCN(c3ccc([N+](=O)[O-])cn3)CC2)C1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>N#CC1CC2(CCN(c3ccc([N+](=O)[O-])cn3)CC2)C1,,COCCOC,,CC(C)(C)O,CC(C)(C)[O-].[K+],val
US20060063805A1,N[C@@H](CO)c1ccccc1.O=C1CSC(=S)N1>>O=C1CSC(N[C@@H](CO)c2ccccc2)=N1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080207654A1,CCCC(=O)CC(=O)OCC.COc1cc(CBr)ccc1-c1ccccc1C#N>>CCCC(=O)C(Cc1ccc(-c2ccccc2C#N)c(OC)c1)C(=O)OCC,,C1CCOC1,,Cl,[H-].[Na+],val
US20100075961A1,CC(C)(C(=O)O)C1(c2ccc3c(cnn3-c3ccc(F)cc3)c2)CCOCC1.Fc1nc(F)nc(F)n1>>CC(C)(C(N)=O)C1(c2ccc3c(cnn3-c3ccc(F)cc3)c2)CCOCC1,,ClCCl,,c1ccncc1,,val
US20120208810A1,Clc1ccccc1CBr.O=c1cc(N2CCOCC2)nc2n1CC[C@@H](C(F)(F)F)N2>>O=c1cc(N2CCOCC2)nc2n1CC[C@@H](C(F)(F)F)N2Cc1ccccc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20040242867A1,CC(CCN)NCCCC1OCCO1>>C1CNC2CCCN2C1,,O,,Cl,[Na+].[OH-],val
US20070010457A1,CC(C)(C)OC(=O)CC(NC(=O)C1CCCCN1)C(O)CF.CN(C)C=O.O=C(O)c1csc(-c2ccccc2)n1>>COC(=O)[C@@H]1CCCCN1C(=O)OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20040147580A1,COC(=O)CN(C(=O)OC(C)(C)C)c1ccc(Br)cn1>>COC(=O)CNc1ccc(Br)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050004164A1,Br[Mg]c1cccc2ccccc12.CCOC(=O)/C(C#N)=C/c1c(OC)cccc1OC>>CCOC(=O)C(C#N)C(c1c(OC)cccc1OC)c1cccc2ccccc12,,C1CCOC1,,,,val
US20080293712A1,COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)Cc5ccc(NC(=O)OCc6ccccc6)cc5)c4)cc3c2cc1OC>>COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)Cc5ccc(N)cc5)c4)cc3c2cc1OC,[Pd],CC(=O)O,CCO,,,val
US05342848,Brc1ccncc1.COC1CCCCC1=O>>COC1CCCCC1(O)c1ccncc1,,CCOCC,O,CCCCCC,[Li]CCCC,val
US20120034270A1,CC(C)(C)OC(=O)NC1(CCc2ccc(CCCn3cc(C(=O)C(F)(F)F)c4ccccc43)cc2)COC(C)(C)OC1>>NC(CO)(CO)CCc1ccc(CCCn2cc(C(=O)C(F)(F)F)c3ccccc32)cc1,,CO,,Cl,ClCCl,val
US20060160865A1,CN(C(=O)Oc1ccc(N=C=S)cn1)c1ccccc1.NC1CCCCC1>>CN(C(=O)Oc1ccc(NC(=S)NC2CCCCC2)cn1)c1ccccc1,,ClCCl,,,,val
US20030153564A1,CC(C)(C)OC(=O)NCCBr.CCN(CC)CC.CN(C)C=O.N#Cc1ccc(NCCCN2CC3CNCC(C2)O3)cc1>>CC(C)(C)OC(=O)NCCN1CC2CN(CCCNc3ccc(C#N)cc3)CC(C1)O2.[NH4+].[OH-],,CN(C)C=O,,,,val
US20140206663A1,CC1C(=O)NN=C2COc3cc(F)c(NC4CN(C(=O)OC(C)(C)C)C4)cc3N21.Cl>>CC1C(=O)NN=C2COc3cc(F)c(NC4CNC4)cc3N21.Cl,,CCOC(C)=O,,,,val
US20150105373A1,COCC(N)c1ccc(OC(F)(F)F)cc1.O=C1CN(C(=O)Oc2ccc([N+](=O)[O-])cc2)c2ncccc2N1>>COCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)cc1,,CC(=O)N(C)C,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20110319380A1,CNC.O=c1c2ccc(Br)cc2nc2n1CC(OS(=O)(=O)c1ccccc1)CC2>>CN(C)C1CCc2nc3cc(Br)ccc3c(=O)n2C1,,CC#N,O,,,val
US04999436,COC(=O)/C=C(\SCc1ccccc1)c1ccccc1C>>Cc1ccccc1-c1cc(O)c(-c2ccccc2)s1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20050158863A1,CC(=O)c1c(O)cc(O)cc1O.CCCCN.CCO>>CC(=O)c1c(O)cc(O)cc1O.CCCCN.O,,CCO,,,,val
US20050284087A1,CCO[Si](OCC)(OCC)OCC.O>>CCO[Si](OCC)(OCC)OCC.O,,C1CCOC1,,Cl,,val
US20020165229A1,COc1ccc(CN)cc1.N#Cc1cnc2cnc(F)cc2c1Nc1cccc(Br)c1>>COc1ccc(CNc2cc3c(Nc4cccc(Br)c4)c(C#N)cnc3cn2)cc1,,CCO,,CO,ClC(Cl)Cl,val
US20100286125A1,COC(=O)CC[C@@H](O)c1ccc(F)cc1>>O=C1CC[C@H](c2ccc(F)cc2)O1,O=C(O)C(F)(F)F,ClCCl,,,,val
US20110059954A1,COc1ccc2c(c1)CCN(C1CCNCC1)C(=O)N2.Cc1cc(C(=O)c2cc(Cl)ncn2)cc2c1N(C)CC2(C)C>>COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)c4cc(C)c5c(c4)C(C)(C)CN5C)ncn3)CC1)C(=O)N2,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US06034086,O=C(O)c1cc(F)c(F)c(C(F)(F)F)c1F.O=S(Cl)Cl>>O=C(Cl)c1cc(F)c(F)c(C(F)(F)F)c1F,CN(C)C=O,c1ccccc1,,,,val
US20120142659A1,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.COC1CCNCC1>>COC1CCN(C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)CC1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120142707A1,C=C(C)[C@@H]1CC[C@]2(C(=O)OCc3ccccc3)CC[C@]3(C)[C@H](CCC4[C@@]5(C)CC=C(c6ccc(C(=O)Cl)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CC(C)S(N)(=O)=O>>C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CCC4[C@@]5(C)CC=C(c6ccc(C(=O)NS(=O)(=O)C(C)C)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,CN(C)c1ccncc1,COCCOC,,CCN(C(C)C)C(C)C,,val
US20120088767A1,COC(=O)c1cc(N2CCOCC2)cc2c1nc(C)n2Cc1cccc(C(F)(F)F)c1C>>Cc1c(Cn2c(C)nc3c(CO)cc(N4CCOCC4)cc32)cccc1C(F)(F)F,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06277790B1,CCCN(C(=O)Cl)c1c(C)csc1C.O=c1nn[nH]n1-c1ccccc1F>>CCCN(C(=O)n1nnn(-c2ccccc2F)c1=O)c1c(C)csc1C,CN(C)c1ccncc1,,,,,val
US04406902,CC1(C)CC1C(=O)N/C(=C\CCCCBr)C(=O)O.O=C(O)c1cccnc1S>>CC1(C)CC1C(=O)N/C(=C\CCCCSc1ncccc1C(=O)O)C(=O)O,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20070129347A1,C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C1(c2ccccc2)CCC(CC(=O)O)CC1.CN(C)C=O.O=C(NC1CCCCC1)NC1CCCCC1>>CC(Cc1c[nH]c2ccccc12)NC(=O)CC1CCC(c2ccccc2)(N(C)C)CC1,,CN(C)C=O,O,Cl,[Na+].[OH-],val
US20100261755A1,COC(=O)C1CCNC(c2ccccc2)C1.COC(=O)Cl>>COC(=O)C1CCN(C(=O)OC)C(c2ccccc2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160159820A1,CN1C(C)(C)CC(Oc2ccc(C(=O)O)cc2C(F)(F)F)CC1(C)C.N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3[C@@H]12>>CN1C(C)(C)CC(Oc2ccc(C(=O)N[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7c6CCC(=O)N7)cc5[C@@H]34)cc2C(F)(F)F)CC1(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140303141A1,CCOC(=O)c1cnn(C)c1C(=O)Nc1ccc2nc(N3CCOCC3)nn2c1>>Cn1ncc(C(=O)O)c1C(=O)Nc1ccc2nc(N3CCOCC3)nn2c1,,CO,O,[Li+].[OH-],,val
US04521537,CN1CCC(OCc2ccccc2F)(C2SCCCS2)CC1.Cl.O>>CN1CCC(C=O)(OCc2ccccc2F)CC1.Cl,,C1CCOC1,CCOCC,FB(F)F,,val
US20100249123A1,CC(C)(CCl)c1ccc([N+](=O)[O-])cc1.C[Si](C)(C)C#N>>CC(C)(CC#N)c1ccc([N+](=O)[O-])cc1,,CC#N,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150164974A1,COC(=O)c1ccc(CO[C@H]2C[C@@H](C(=O)N[C@@H]3CCCc4ccccc43)N(C(=O)OC(C)(C)C)C2)cc1.Cl>>COC(=O)c1ccc(CO[C@@H]2CN[C@H](C(=O)N[C@@H]3CCCc4ccccc43)C2)cc1.Cl,,ClCCl,,,,val
US20090082403A1,C[N+](=O)[O-].O=Cc1ccc(COc2ccccn2)cc1>>O=[N+]([O-])/C=C/c1ccc(COc2ccccn2)cc1,,CC(=O)O,,C,O=C[O-].[NH4+],val
US20150152096A1,CC(C)(C)C(=O)OCCl.CCOC(=O)C1=C(CN2CCOCC2C(=O)O)NC(c2nccs2)=NC1c1ccc(Cl)cc1Cl>>CCOC(=O)C1=C(CN2CCOCC2C(=O)OCOC(=O)C(C)(C)C)NC(c2nccs2)=NC1c1ccc(Cl)cc1Cl,,CN(C)C=O,,ClCCl,,val
US20110112151A1,Cc1cc(C)c(C(=O)CBr)c(C)c1.Cn1ccnc1S>>Cc1cc(C)c(C(=O)CSc2nccn2C)c(C)c1,,CC#N,,CCN(CC)CC,,val
US20140256734A1,CC(C)(C)OC(=O)N1CC[C@H](Oc2nc(-c3n[nH]c(=O)[nH]3)cc3cccnc23)C1.Cl>>Cl.O=c1[nH]nc(-c2cc3cccnc3c(O[C@H]3CCNC3)n2)[nH]1,,C1COCCO1,,,,val
US05719182,CCCOc1ccc2c(c1)C(c1ccc(OC)cc1OCOC)C(CC#N)C2c1ccc2c(c1)OCO2>>CCCOc1ccc2c(c1)C(c1ccc(OC)cc1O)C(CC#N)C2c1ccc2c(c1)OCO2,,CCO,Cl,,,val
US20160060258A1,COC(OC)N(C)C.CSc1ncc(C(=O)Nc2c(Cl)cccc2Cl)c(C)n1>>CSc1ncc2c(=O)n(-c3c(Cl)cccc3Cl)ccc2n1,,CN(C)C=O,,,,val
US05223536,COC(=O)C=C(c1ccc(Cl)cc1)C1CC1>>COC(=O)CC(c1ccc(Cl)cc1)C1CC1,,CO,Cl,[Mg],,val
US20110021500A1,CCC1Cc2ccc(F)cc2N1.O=C(O)c1cc(Nc2ccc3c(c2)CC2(C3)C(=O)Nc3ncccc32)ccn1>>CCC1Cc2ccc(F)cc2N1C(=O)c1cc(Nc2ccc3c(c2)CC2(C3)C(=O)Nc3ncccc32)ccn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20110053848A1,CN(CCCCCC(=O)NCCSC(c1ccccc1)(c1ccccc1)c1ccccc1)CCNC(=O)OC(C)(C)C>>CN(CCN)CCCCCC(=O)NCCSC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,C1COCCO1,Cl,,val
US20150011532A1,Cc1oc(-c2cnc(Cl)cc2NC(C)C)nc1C(=O)O.NCCCO>>Cc1oc(-c2cnc(Cl)cc2NC(C)C)nc1C(=O)NCCCO,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060166990A1,COc1ccc(Cl)c(C=O)c1.Clc1cc(Br)ccc1I>>COc1ccc(Cl)c(C(O)c2ccc(Br)cc2Cl)c1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US05547950,CC(=O)NC[C@H]1CN(c2ccc(N3CCNCC3)c(F)c2)C(=O)O1.OCCCCl>>CC(=O)NC[C@H]1CN(c2ccc(N3CCN(CCCO)CC3)c(F)c2)C(=O)O1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20070032519A1,CC(C)(C)OC(=O)N(Cc1ccc(C(F)(F)F)cc1)c1ccc(C=O)cn1.c1cc2cc(OCCN3CCOCC3)cnc2[nH]1>>CC(C)(C)OC(=O)N(Cc1ccc(C(F)(F)F)cc1)c1ccc(C(O)c2c[nH]c3ncc(OCCN4CCOCC4)cc23)cn1,,CO,,[K+].[OH-],,val
US20150291525A1,COCOCc1cc(Cn2ncc3cc(C(C)(C)C)cc(F)c3c2=O)ccc1Br.COc1cc(B(O)O)ccn1>>COCOCc1cc(Cn2ncc3cc(C(C)(C)C)cc(F)c3c2=O)ccc1-c1ccnc(OC)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US04532239,Clc1ccccc1OCC1CO1.NCCN>>NCCNCC(O)COc1ccccc1Cl,,CCO,,,,val
US20140080705A1,CCc1nnc(N)o1.O=C(O)c1ccc(C(F)(F)F)nc1Cl>>CCc1nnc(NC(=O)c2ccc(C(F)(F)F)nc2Cl)o1,CN(C)c1ccncc1,ClCCl,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US06284796B1,CC(C)(C)Oc1ccc2cc(Br)ccc2c1.CN(C)C=O>>CC(C)(C)Oc1ccc2cc(C=O)ccc2c1,,C1CCOC1,,[Li]CCCC,,val
US20090062328A1,CC(C)Cn1c(C=O)nc2cnc3ccccc3c21.CON>>CON=Cc1nc2cnc3ccccc3c2n1CC(C)C,,CO,,Cl,,val
US20130150341A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(Cl)Cn1nc(-c2ccc(F)cc2)nc1-c1ccc(F)cc1>>CC(C)(C)OC(=O)N1CCN(C(=O)Cn2nc(-c3ccc(F)cc3)nc2-c2ccc(F)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20100113502A1,CCS(=O)(=O)n1c2c(c3cc(C(=O)N4CCC(COC(=O)C(F)(F)F)CC4)ccc31)CNCC2.O=C1CCC1>>CCS(=O)(=O)n1c2c(c3cc(C(=O)N4CCC(CO)CC4)ccc31)CN(C1CCC1)CC2,,ClCCl,,O=C(O)C(F)(F)F,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US06040309,COc1cccc(Sc2c(C(=O)O)sc3cc(Cn4cnc5cnccc54)ccc23)c1.OO>>COc1cccc(S(=O)c2c(C(=O)O)sc3cc(Cn4cnc5cnccc54)ccc23)c1,,CC(=O)O,,Cl,O,val
US20150158879A1,CS(=O)(=O)CCCl.OCc1nc2ccccc2[nH]1>>CS(=O)(=O)CCn1c(CO)nc2ccccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040142943A1,CCOC(=O)N(C)C(C)C(F)(F)F.Cl>>CNC(C)C(F)(F)F.Cl,,O,,CCO,[K+].[OH-],val
US20060229312A1,CC(C)I.Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1.Cl.Cl>>Cc1ccc2c(N3CCN(CCc4cccc(N5CCN(C(C)C)C5=O)c4)CC3)cccc2n1.Cl.Cl,,CN(C)C=O,,[H-].[Na+],,val
US20120035214A1,BrCc1ccc(Br)cc1.CC(C)(C)[Si](C)(C)OCC(F)(F)CO>>CC(C)(C)[Si](C)(C)OCC(F)(F)COCc1ccc(Br)cc1,,C1CCOC1,,[H-].[Na+],,val
US05169856,CC(=O)Cl.Cl.O=C(/C=C/c1ccccc1)NCCC1CCN(Cc2ccccc2)CC1>>CC(=O)N(CCC1CCN(Cc2ccccc2)CC1)C(=O)/C=C/c1ccccc1.Cl,,O,,c1ccncc1,,val
US20150152050A1,CC([C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cc(CCC(=O)OC(C)(C)C)ccc1Cl)C(F)(F)F>>CC([C@H](N)C(=O)Nc1cc(CCC(=O)OC(C)(C)C)ccc1Cl)C(F)(F)F,[Pd],CCOC(C)=O,,,,val
US20130274244A1,Brc1cccc(C2CC2)n1.CN(C)C=O>>O=Cc1cccc(C2CC2)n1,,C1CCOC1,,[Li]CCCC,,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccccc4F)nc(Cl)c3n2)cc1.Nc1ccc(N2CCOCC2)cc1>>Fc1ccccc1-c1nc(Nc2ccc(N3CCOCC3)cc2)c2[nH]ncc2n1,C1COCCO1,CO,,Cl,,val
US20080269288A1,O=C(NC1CCCCC1)c1ccc(Cl)nc1Cl.SCCc1ccccc1>>O=C(NC1CCCCC1)c1ccc(Cl)nc1SCCc1ccccc1,,CN(C)C=O,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US04104049,CCOC=C(C(C)=O)C(C)=O.Nc1cc(Cl)c(Cl)c(C(=O)O)c1Cl>>CC(=O)C(=CNc1cc(Cl)c(Cl)c(C(=O)O)c1Cl)C(C)=O,,Cc1ccccc1,,,,val
US06232290B1,COC(=O)c1cnn(-c2ccc([N+](=O)[O-])cc2)c1>>COC(=O)c1cnn(-c2ccc(N)cc2)c1,[Fe],O,,CO,[Cl-].[NH4+],val
US20160157491A1,C=Cc1ccc2c([N+](=O)[O-])c(OS(=O)(=O)C(F)(F)F)ccc2c1.Nc1ccc(SC(F)(F)F)cc1>>C=Cc1ccc2c([N+](=O)[O-])c(Nc3ccc(SC(F)(F)F)cc3)ccc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])[O-].[K+].[K+],val
US20100063101A1,CCOC(=O)C(Br)C1CCCCC1.Clc1ccc(-c2nc3ccccc3[nH]2)cc1>>CCOC(=O)C(C1CCCCC1)n1c(-c2ccc(Cl)cc2)nc2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080255347A1,CNCCc1ccc(O)cc1>>CNCCc1ccc(O)cc1,,CO,,Br,[Na+].[OH-],val
US20120245345A1,COc1ccc2ncc3c(c2c1)C(OC(C)=O)C([C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1)C(OC(C)=O)O3>>COc1ccc2ncc3c(c2c1)CC([C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1)C(OC(C)=O)O3,[Pd],CO,,,,val
US20030162787A1,Cc1cc(-c2ccccc2S(C)(=O)=O)ccc1NC(=O)C1CCCN1C(=O)OC(C)(C)C>>Cc1cc(-c2ccccc2S(C)(=O)=O)ccc1NC(=O)C1CCCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120165318A1,COC(=O)c1ccc2nc(-c3ccccc3)c(Br)nc2c1.COc1ccc(N2CCNCC2)cc1>>COC(=O)c1ccc2nc(-c3ccccc3)c(N3CCN(c4ccc(OC)cc4)CC3)nc2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20110136802A1,COc1cc(O)cc2c1[C@]1(C)CC[C@H]3C(C)(C)CCC[C@]3(C)[C@H]1CS2(=O)=O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1cc(OS(=O)(=O)C(F)(F)F)cc2c1[C@@H]1CC[C@H]3C(C)(C)CCC[C@]3(C)[C@H]1CS2(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20030166639A1,Cc1ccc(-c2cccc(C(=O)CC(=O)Nc3cc(-c4ccccc4F)ccc3NC(=O)OC(C)(C)C)c2)nn1>>Cc1ccc(-c2cccc(C3=Nc4ccc(-c5ccccc5F)cc4NC(=O)C3)c2)nn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120328691A1,CCOC(=O)c1csc(-c2cc(C)on2)n1>>Cc1cc(-c2nc(C(=O)O)cs2)no1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US04845097,COC(C)Cc1ccc(OCCN)c(C)c1.Clc1ncnc2ccccc12>>COC(C)Cc1ccc(OCCNc2ncnc3ccccc23)c(C)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20160038504A1,Cc1ccc(N)cc1B1OC(C)(C)C(C)(C)O1.Clc1cc(N2CCOCC2)c2nccn2n1>>Cc1ccc(N)cc1-c1cc(N2CCOCC2)c2nccn2n1,,COCCOC,,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20080114019A1,CC(=O)OCCCNc1c(N)cnc2cccnc12.CCCC(=O)Cl>>CCCC(=O)Nc1cnc2cccnc2c1NCCCOC(C)=O.Cl,,ClCCl,,,,val
US04621901,C=CCCC[C@@H]1CC[C@@H](C(=O)O)CC1.CCOc1ccc(O)cc1>>C=CCCC[C@@H]1CC[C@@H](C(=O)Oc2ccc(OCC)cc2)CC1,CN(C)c1ccncc1,CCOCC,ClCCl,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04377695,CCOC(=O)CCCCCCn1c(=O)oc2ccccc21>>O=C(O)CCCCCCn1c(=O)oc2ccccc21,,CO,,[Na+].[OH-],,val
US20140283218A1,C[Mg]Cl.O=Cc1sc(-c2cccnc2)nc1Cl>>CC(O)c1sc(-c2cccnc2)nc1Cl,,C1CCOC1,,CC(=O)O,O,val
US20080305081A1,C[C@@]1(C(=O)O)CCCN1.O=C(Cl)OCc1ccccc1>>C[C@@]1(C(=O)O)CCCN1C(=O)OCc1ccccc1,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20040171649A1,CCOC(=O)C1(O)CC(C(F)(F)F)=NN1c1ncccc1Cl>>CCOC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl,O=S(=O)(O)O,CC(=O)O,,,,val
US04800199,CC(=O)OCC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](NC(N)=S)[C@H]2SC1.CCOC(=O)C(=O)CBr>>CCOC(=O)c1csc(NC2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=CCSC23)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04324726,COC1CC(N)C(C)(CO)O1>>COC1C[C@H](N)[C@@H](O)[C@H](C)O1,,CCN(CC)CC,,CO,,val
US20090018122A1,CCOCc1nc2c(N)nc3cc(O)ccc3c2n1CC(C)C.Cc1ccccc1CCl>>CCOCc1nc2c(N)nc3cc(OCc4ccccc4C)ccc3c2n1CC(C)C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030144300A1,CC(=O)c1ccc(C#N)cc1.C[Mg]Cl>>CC(C)(O)c1ccc(C#N)cc1,,C1CCOC1,,,,val
US20090239854A1,Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.FC(F)(F)c1ccc(CCCBr)cn1>>Cc1ccc2c(c1)c1c(n2CCCc2ccc(C(F)(F)F)nc2)CCN(C)C1,,O,,CN(C)C=O,[H-].[Na+],val
US20110305661A1,CC(=O)Cl.COc1ccc2c(c1)[nH]c1ccc3c(c12)CCC3=O>>COc1cc2[nH]c3ccc4c(c3c2cc1C(C)=O)CCC4=O,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130079313A1,COC(=O)c1cc(N)ccc1O.CS(=O)(=O)Cl>>COC(=O)c1cc(NS(C)(=O)=O)ccc1O,,ClCCl,O,Cl,c1ccncc1,val
US20110306589A1,CCOC(=O)c1c([N+](=O)[O-])cnn1C>>CCOC(=O)c1c(N)cnn1C,[Pd],CCO,,,,val
US20090111809A1,CC(C)[Si](OC1CCN(N2CC[C@@H](Cc3c(Cl)cc(-c4ccc(C(=O)N5CCC(F)(F)CC5)cc4)cc3Cl)C2=O)CC1)(C(C)C)C(C)C>>O=C(c1ccc(-c2cc(Cl)c(C[C@@H]3CCN(N4CCC(O)CC4)C3=O)c(Cl)c2)cc1)N1CCC(F)(F)CC1,,C1CCOC1,,O,O=C(O)C(F)(F)F,val
US20130065905A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.OC(c1ccnc(Br)c1)C(F)(F)F>>CC(C)(C)[Si](C)(C)OC(c1ccnc(Br)c1)C(F)(F)F,,ClCCl,,CCN(CC)CC,O,val
US04561876,CCC1(N)COCOC1.O=C(Cl)C(Br)CCl>>CCC1(NC(=O)C(Br)CCl)COCOC1,,ClCCl,,O,[Na+].[OH-],val
US20120077793A1,CC(C)(C)OC(=O)NC(C(=O)N1CCC[C@H]1C(N)=O)c1ccc(OS(=O)(=O)C(F)(F)F)cc1>>CC(C)(C)OC(=O)NC(C(=O)N1CCC[C@H]1C#N)c1ccc(OS(=O)(=O)C(F)(F)F)cc1,,C1CCOC1,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US20040192767A1,COC(=O)c1cc(CO)c(C)o1.Sc1ccc(Br)cc1>>COC(=O)c1cc(CSc2ccc(Br)cc2)c(C)o1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080058309A1,CC(C)(C)[Si](C)(C)O[C@@H]1CCN(c2ccc3c(NC(=O)CCl)c(Cl)ccc3n2)C1.Nc1ccc(F)c(F)c1>>O=C(CNc1ccc(F)c(F)c1)Nc1c(Cl)ccc2nc(N3CC[C@@H](O)C3)ccc12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160222030A1,CC(C)OC(=O)/N=N/C(=O)OC(C)C.COc1cccc(OC)c1C(=O)N[C@@H]1COC[C@@H]1O.O=C1NC(=O)c2ccccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cccc(OC)c1C(=O)N[C@@H]1COC[C@H]1N1C(=O)c2ccccc2C1=O.O=P(c1ccccc1)(c1ccccc1)c1ccccc1,,ClCCl,,,,val
US20150218144A1,COc1ccc(C[C@@H]2CN(C(=O)OC(C)(C)C)CCO2)cn1>>COc1ccc(C[C@@H]2CNCCO2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120323002A1,NNc1cc(N2CCOCC2)c2nc(-c3ccncc3)cn2n1.O=Cc1ccc(CF)cc1>>FCc1ccc(C=NNc2cc(N3CCOCC3)c3nc(-c4ccncc4)cn3n2)cc1,,CCO,,,,val
US20140364413A1,CCOC(=O)NS(C)(=O)=O.Nc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1>>CS(=O)(=O)NC(=O)Nc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20120172351A1,BrBr.Cc1cc2cc(F)ccc2[nH]1>>Cc1[nH]c2ccc(F)cc2c1Br,,ClCCl,,,,val
US20110071150A1,O=[N+]([O-])c1ccc2[nH]c(-c3c(F)cccc3F)cc2c1>>Nc1ccc2[nH]c(-c3c(F)cccc3F)cc2c1,[Pd],CCOC(C)=O,,,,val
US20070149521A1,NC(c1cccc(OCc2ccccc2)c1)c1nccnc1Cl.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]c(-c2cccc(OCc3ccccc3)c2)c2c(Cl)nccn12,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20080119468A1,Cc1cc(SC(=O)N(C)C)ccc1Br>>Cc1cc(S)ccc1Br,,CO,,[K+].[OH-],,val
US05719161,COCCOC(=O)Nc1cccc(C)c1CCl.Cc1nc2c(O)cccn2c1CO>>COCCOC(=O)Nc1cccc(C)c1COc1cccn2c(CO)c(C)nc12,,CC(C)=O,,[I-].[Na+],,val
US20040087568A1,CC(=O)N1CC(C)(C)c2ccc(N)cc21.O=c1[nH]c2ccccc2c(=O)o1>>CC(=O)N1CC(C)(C)c2ccc(NC(=O)c3ccccc3N)cc21,,CS(C)=O,,O=C([O-])O.[Na+],,val
US04125732,CC(Oc1ccc(C(F)(F)F)cc1)(C(=O)O)c1ccc(OCOc2ccc(Cl)cc2)cc1>>O=C(O)C(Oc1ccc(C(F)(F)F)cc1)c1ccc(OCOc2ccc(Cl)cc2)cc1,,CCO,O,Cl,[K+].[OH-],val
US20110160198A1,COC(=O)[C@H](Cc1ccc(Br)s1)NC(=O)OC(C)(C)C.N#Cc1ccc(B(O)O)cc1>>COC(=O)[C@H](Cc1ccc(-c2ccc(C#N)cc2)s1)NC(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20100305085A1,NNc1cc(Cl)ncn1.c1cc(N2CCCC2)ccn1>>NNc1cc(N2CCC(N3CCCC3)CC2)ncn1,,O,,,,val
US03976684,COS(=O)(=O)OC.O=C1Cc2cc(O)cc(O)c2C2CCCCC12>>COc1cc2c(c(OC)c1)C1CCCCC1C(=O)C2,,O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20110230518A1,CNC.COC(=O)c1ccc(-c2ccccc2C)c(COC(C)=O)c1>>COC(=O)c1ccc(-c2ccccc2C)c(CN(C)C)c1,,ClCCl,,CCN(C(C)C)C(C)C,CS(=O)(=O)Cl,val
US05010060,CCc1cn([C@H]2C[C@H](O)[C@@H](CN)O2)c(=O)[nH]c1=O.O=C(Cl)Cc1cccs1>>CCc1cn([C@H]2C[C@H](O)[C@@H](CNC(=O)Cc3cccs3)O2)c(=O)[nH]c1=O,,O,,[Na+].[OH-],,val
US20110105461A1,CS(=O)(=O)c1cc(F)c2c(c1)O[C@@H](CO)CO2.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20100069383A1,COc1ccc(N(C)c2nc(Cl)nc3ccc([N+](=O)[O-])cc23)cc1.NCCO>>COc1ccc(N(C)c2nc(NCCO)nc3ccc([N+](=O)[O-])cc23)cc1,,CCCCO,,,,val
US20160106754A1,CC1(C)CNC(=O)C2=C1Nc1ccc(OC(F)(F)F)cc1S2.O=P([O-])([O-])[O-]>>CC1(C)CNC(=O)C2=C1Nc1ccc(OC(F)(F)F)cc1S2=O,,CC#N,,,,val
US05179124,CCOC(=O)C(C)c1ccc(O)cc1.OCCCCl>>CC(C(=O)O)c1ccc(OCCCO)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160264518A1,CC(C)(C)OC(=O)CCc1cccc(CBr)c1.COC(=O)/C=C/c1ccccc1N>>COC(=O)/C=C/c1ccccc1NCc1cccc(CCC(=O)OC(C)(C)C)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140343092A1,CCOC(=O)c1c(C#N)ccn1Cc1ccccc1>>N#Cc1ccn(Cc2ccccc2)c1C(=O)O,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US20060217374A1,BrCc1ccccc1.O=C1CCc2cc(O)ccc2N1>>O=C1CCc2cc(OCc3ccccc3)ccc2N1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110251186A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1=N[C@@]2(COC1)c1cc(O)ccc1Oc1c(F)cc(C3=CCCOC3)cc12>>CC(C)(C)OC(=O)NC1=N[C@@]2(COC1)c1cc(O)ccc1Oc1c(F)cc(C3=CCCOC3)cc12,,C1CCOC1,,CCN(CC)CC,,val
US04882330,O=[N+]([O-])c1ccc(N2CCN(CCC(O)COc3ccccc3)CC2)cc1>>Nc1ccc(N2CCN(CCC(O)COc3ccccc3)CC2)cc1,[Pd],,,[H][H],,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4ncnn4C)cc2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4ncnn4C)cc2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20080293716A1,CC(=O)c1ccc(C(=O)O)s1.NCc1ccccc1>>CC(=O)c1ccc(C(=O)NCc2ccccc2)s1,,ClCCCl,,On1nnc2ccccc21,,val
US20040242508A1,CCN(CC)CCN.CO[C@H]1[C@H](O)[C@@H](O)[C@H](n2c3ccccc3c3c4c(c5c6ccccc6[nH]c5c32)C(=O)OC4=O)O[C@@H]1CO>>CCN(CC)CCN1C(=O)c2c(c3c4ccccc4n([C@@H]4O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]4O)c3c3[nH]c4ccccc4c23)C1=O,,C1CCOC1,,CCOC(C)=O,Cl,val
US03980633,C[n+]1ncc(N)cc1Cl.Oc1ccccc1.[O-][Cl+3]([O-])([O-])[O-]>>C[n+]1ncc(N)cc1Oc1ccccc1.[O-][Cl+3]([O-])([O-])[O-],,c1ccncc1,,CC#N,,val
US20070111988A1,CC(C)(C)[Si](Oc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3ccc(C=O)cc3)sc2c1)(c1ccccc1)c1ccccc1>>O=Cc1ccc(-c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20060217387A1,Cc1cc(C(=O)CC(=O)C(F)(F)F)ccc1C(F)(F)F.Nc1cc[nH]n1>>Cc1cc(-c2cc(C(F)(F)F)n3nccc3n2)ccc1C(F)(F)F,,CC(=O)O,,,,val
US20160229872A1,COC(=O)/C=C(\c1ccccc1)C(F)F>>COC(=O)CC(c1ccccc1)C(F)F,[Pd],CO,,[H][H],,val
US20030055261A1,CC(C)(C)OC(=O)NC(Cc1cccc2ccccc12)C(=O)O.CI>>CN(C(=O)OC(C)(C)C)[C@H](Cc1cccc2ccccc12)C(=O)O,,C1CCOC1,O,CCOC(C)=O,[H-].[Na+],val
US20030181466A1,COC(=O)C(Br)=NNc1ccc(Cl)cc1.O=C1C(N2CCOCC2)=CCCN1c1ccc(I)cc1>>COC(=O)C1=NN(c2ccc(Cl)cc2)C2(N3CCOCC3)C(=O)N(c3ccc(I)cc3)CCC12,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,O,val
US20150126491A1,COC(=O)CC1C(=O)[C@@]2(C)CC[C@@H]1C2(C)C.NN>>CC1(C)[C@H]2CC[C@]1(C)C(=O)C2CC(=O)NN,,CCO,,O,,val
US04891447,C=CCCC(C)(C)O.COS(=O)(=O)OC>>C=CCCC(C)(C)OC,,C1CCOC1,,[H-].[Na+],,val
US20090318407A1,CC(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NCC4CCNCC4)n3)cc2)CC1.CC(=O)OC(C)=O>>CC(=O)N1CCC(CNc2nc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)ncc2C(N)=O)CC1,,CC#N,,CCN(CC)CC,,val
US05247085,CCOP(=O)(CO[C@H](CO)COn1cnc2c(N)ncnc21)OCC>>Nc1ncnc2c1ncn2OC[C@@H](CO)OCP(=O)(O)O,,CN(C)C=O,,C[Si](C)(C)Br,,val
US20150023990A1,CCCn1c(COCC)nc2c(N)nc3ccc(OCc4ccccc4)cc3c21>>CCCn1c(COCC)nc2c(N)nc3ccc(O)cc3c21,[Pd],CCO,CO,,,val
US20070060567A1,CI.COC(=O)c1cc(O)c2cc[nH]c2c1>>COC(=O)c1cc(OC)c2cc[nH]c2c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120220795A1,CC(=O)c1ccc(I)cc1.CCOC(=O)C(F)(F)Br>>CCOC(=O)C(F)(F)c1ccc(C(C)=O)cc1,[Cu],CS(C)=O,,,,val
US20110165118A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)OC(=O)c1[nH]c2ccc(C(F)(F)F)cc2c1-n1c(=O)[nH]c2cscc2c1=O>>CC(C)(C)OC(=O)c1[nH]c2ccc(C(F)(F)F)cc2c1-n1c(=O)c2cscc2n(C(=O)OC(C)(C)C)c1=O,CN(C)c1ccncc1,C1COCCO1,,CCOC(C)=O,,val
US20080009619A1,BrCc1ccccc1Br.CCOP(OCC)OCC>>CCOP(=O)(Cc1ccccc1Br)OCC,,Cc1ccccc1C,,,,val
US20140336185A1,COC(=O)c1ccc(NC(=O)Cc2ccc(OC)cc2C(F)(F)F)cn1>>COc1ccc(CC(=O)Nc2ccc(C(=O)O)nc2)c(C(F)(F)F)c1,,CO,,C1CCOC1,[Na+].[OH-],val
US04493843,CCCCCCCCCCCCCCCC(=O)Nc1cc(C(=O)O)ccc1C>>CCCCCCCCCCCCCCCc1cc2ccc(C(=O)O)cc2[nH]1,,O,,Cl,CC(C)(C)[O-].[K+],val
US20090270402A1,CC(C)c1nnc2ccc(-c3c[nH]nc3-c3ccc(F)cc3F)nn12.OC1CCOCC1>>CC(C)c1nnc2ccc(-c3cn(C4CCOCC4)nc3-c3ccc(F)cc3F)nn12,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100152450A1,CC(C)(C)OC(=O)N1CCC[C@@H](CCCOCc2ccccc2)C1>>c1ccc(COCCC[C@@H]2CCCNC2)cc1,,ClCCl,O,O=C(O)C(F)(F)F,,val
US20080188528A1,CC(C)c1cccc(-c2ccccc2Cn2cccc(C(=O)O)c2=O)c1.Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](N)C(=O)OC(C)(C)C)c(C)c2c1OC(C)(C)CC2>>Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)c2cccn(Cc3ccccc3-c3cccc(C(C)C)c3)c2=O)C(=O)OC(C)(C)C)c(C)c2c1OC(C)(C)CC2,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020132817A1,Cc1ccc(Br)cc1.O=C1OC(=O)c2ncccc21>>Cc1ccc(C(=O)c2cccnc2C(=O)O)cc1,,C1CCOC1,,II,[Mg],val
US20120071462A1,CC(=N)NO.O=C(O)c1cccc(Oc2ccc3c(c2)S(=O)(=O)NCCO3)c1>>C/C(=N/O)NC(=O)c1cccc(Oc2ccc3c(c2)S(=O)(=O)NCCO3)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20060142312A1,CCOC(=O)CC(=O)c1ccccc1.CSc1ncc(C=O)c(NC2CCCC2)n1>>CSc1ncc2cc(C(=O)c3ccccc3)c(=O)n(C3CCCC3)c2n1,,CCO,,C1CCNCC1,,val
US03946049,COc1ccc(N)cc1.O=Cc1ccco1>>COc1ccc(-c2ccc(C=O)o2)cc1,,O,,Cl,O=N[O-].[Na+],val
US20150210682A1,CCCOc1cc2c(cc1OC)C=NC(CC)C2.CCOC=C(C(C)=O)C(=O)OCC>>CCCOc1cc2c(cc1OC)C1CC(=O)C(C(=O)OCC)=CN1C(CC)C2,,CCO,,,,val
US06028116,COc1ccc2c(c1)C(CC(=O)Cl)=C(C)/C2=C/c1ccc(SC)cc1>>COc1ccc2c(c1)C(CCO)=C(C)/C2=C/c1ccc(SC)cc1,,C1CCOC1,,[BH4-].[Li+],,val
US20160176868A1,CCOC(=O)C1=C(NC(=O)NC(C)C)N[C@@H](c2cccc(OC)c2)CC1>>COc1cccc([C@H]2CCc3c([nH]c(=O)n(C(C)C)c3=O)N2)c1,,CCO,,C,C[O-].[Na+],val
US20110021496A1,CC(C)(C)OC(=O)N1CC2CN(Cc3cc4nc(Cl)nc(N5CCOCC5)c4s3)CC2C1.C[Si](C)(C)N=C=O>>NC(=O)N1CC2CN(Cc3cc4nc(Cl)nc(N5CCOCC5)c4s3)CC2C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070054928A1,NCc1ccccc1.O=C(O)C1(C(=O)O)CC1>>O=C(O)C1(C(=O)NCc2ccccc2)CC1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,O=S(Cl)Cl,val
US20110224433A1,COCc1cnc(C(=O)OC)c(C(=O)OC)c1>>COCc1cnc(C(=O)O)c(C(=O)O)c1,,O,,[Na+].[OH-],,val
US20120178715A1,NC(C(=O)O)c1ccccc1Br>>NC(CO)c1ccccc1Br,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100239219A1,O=C1CCC(=O)O1.c1cc2ccc3ccc4ccc5ccc6ccc1c1c2c3c4c5c61>>O=C(O)CCC(=O)c1cc2ccc3ccc4ccc5ccc6ccc1c1c6c5c4c3c21,,O=[N+]([O-])c1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080114022A1,COC(=O)Cc1c(C)n(Cc2ccccc2)c2ncccc12>>Cc1c(CC(=O)O)c2cccnc2n1Cc1ccccc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20090318431A1,CI.O=C1Nc2ccccc2CCO1>>CN1C(=O)OCCc2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US04267174,Cc1ccccc1C(=S)Cl.N#CC1CN1>>Cc1ccccc1C(=S)N1CC1C#N,,CCOCC,,O=C([O-])[O-].[Na+].[Na+],,val
US20110015240A1,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.C[Si](C)(C)c1sc(C=O)cc1C1OCCO1>>COC(=O)/C=C/c1cc(C2OCCO2)c([Si](C)(C)C)s1,,ClC(Cl)Cl,,,,val
US20090221687A1,CN(C)C=O.COc1cc(Cl)cc2c1Oc1ccccc1CC2=O.O=P(Cl)(Cl)Cl>>COc1cc(Cl)cc2c1Oc1ccccc1C(C=O)=C2Cl,,ClCCl,,CC(=O)[O-].[Na+],,val
US20160031903A1,N#CC(C#N)/N=N/c1ccccc1.N=C(N)c1cc(-c2ccon2)n(Cc2ccccc2F)n1>>Nc1nc(-c2cc(-c3ccon3)n(Cc3ccccc3F)n2)nc(N)c1/N=N/c1ccccc1,,CC(C)(C)O,,O=C([O-])O.[K+],,val
US20140066443A1,CC(C)Cn1nnc2c(Br)c(-c3ccc(CO)cc3)ccc21.CS(=O)(=O)Cl>>CC(C)Cn1nnc2c(Br)c(-c3ccc(CCl)cc3)ccc21,,ClCCl,,CCN(CC)CC,,val
US20090075970A1,Nn1c(=O)[nH]c2ccsc2c1=O>>O=c1[nH]c(=O)c2sccc2[nH]1,,CC(=O)O,O,O=N[O-].[Na+],,val
US20040058964A1,COC(=O)c1cccc(-n2c(C)cc(O)cc2=O)c1.Fc1ccc(CBr)c(F)c1>>COC(=O)c1cccc(-n2c(C)cc(OCc3ccc(F)cc3F)cc2=O)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120322842A1,Cc1[nH]n(C)c(=O)c1C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1nn(C)c(OS(=O)(=O)C(F)(F)F)c1C,,ClCCl,,Cl,c1ccncc1,val
US20060142359A1,Nc1onc2c1CCC2.O=Cc1ccccc1>>C(=Nc1onc2c1CCC2)c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20100056576A1,COC(=O)c1ccc(F)c(C2CCC(=O)CC2)n1>>COC(=O)c1ccc(F)c(C2CCC(O)CC2)n1,,CO,,[BH4-].[Na+],,val
US05650428,CCOC(=O)Cc1ccc(NC(=O)C(COC2CCCCO2)NC(=O)OCc2ccccc2)cc1.COc1ccc(S(=O)(=O)Cl)cc1>>CCOC(=O)Cc1ccc(NC(=O)C(COC2CCCCO2)NS(=O)(=O)c2ccc(OC)cc2)cc1,[Pd],,,,,val
US20040152697A1,C[C@@H](C(=O)OC(C)(C)C)N1CC[C@H](N(Cc2nccs2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O>>C[C@@H](C(=O)O)N1CC[C@H](N(Cc2nccs2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060264387A1,NCc1ccccn1.O=C(Cl)CCl>>O=C(CCl)NCc1ccccn1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100168418A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C1CC(NCc2ccc(C)c(F)c2)CCN1CCn1c(=O)cnc2ccc(OC)cc21>>COC(=O)C1CC(N(Cc2ccc(C)c(F)c2)C(=O)OC(C)(C)C)CCN1CCn1c(=O)cnc2ccc(OC)cc21,,ClC(Cl)Cl,,ClCCl,O,val
US20120134934A1,O=C(CBr)c1ccccc1.O=C(N[C@@H](C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1)OCc1ccccc1>>O=C(N[C@@H](C(=O)O[C@H]1C[N+]2(CC(=O)c3ccccc3)CCC1CC2)c1ccccc1)OCc1ccccc1.[Br-],,CCOC(C)=O,,,,val
US20100172867A1,NC1Cc2ccccc2N(c2ccccc2)C1.Nc1nc(Cl)c2cn[nH]c2n1>>Nc1nc(NC2Cc3ccccc3N(c3ccccc3)C2)c2cn[nH]c2n1,,CC(=O)N(C)C,O,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20120214791A1,Cc1ccc(-c2c(-c3cn(NC=N)c(C)n3)cnn2C)cc1.O=C(n1ccnc1)n1ccnc1>>Cc1ccc(-c2c(-c3nc(C)n4nc[nH]c(=O)c34)cnn2C)cc1,,C1COCCO1,,[H-].[Na+],,val
US20070106080A1,O=C(Nc1ccc(Cl)cc1)C(F)(F)F.O=P(Cl)(Oc1ccccc1)Oc1ccccc1>>FC(F)(F)C(Cl)=Nc1ccc(Cl)cc1,,CCOC(C)=O,,CC#N,CCN(CC)CC,val
US20070184979A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(-c3cccnc3)cc2)c1>>Nc1ccccc1NC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(-c3cccnc3)cc2)c1,,C1COCCO1,,Cl,,val
US20110212969A1,CCOC(=O)c1ccc(C(N)C(C)C)cc1.O=C(O)C12CC3CC(CC(C3)C1)C2>>CCOC(=O)c1ccc(C(NC(=O)C23CC4CC(CC(C4)C2)C3)C(C)C)cc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110201616A1,CCOC(=O)c1cnc(CBr)s1.Cc1csc(S(=O)(=O)N(C[C@H](C)F)c2cc3c(cc2O)CCC3)n1>>CCOC(=O)c1cnc(COc2cc3c(cc2N(C[C@H](C)F)S(=O)(=O)c2nc(C)cs2)CCC3)s1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US03932429,COc1cccc(C23CCCC(C2)N(C)C3C)c1.O=C(O)[C@@H](O)[C@H](O)C(=O)O>>COc1cccc(C23CCCC(C2)N(C)C3C)c1.O=C(O)[C@@H](O)[C@H](O)C(=O)O,,CCO,,,,val
US05547949,C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CO.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)COS(=O)(=O)c1ccc([N+](=O)[O-])cc1,,C1CCOC1,,CCN(CC)CC,O,val
US06509341B1,Cc1cc(C)nc(OC(C(=O)O)C(OCCNC(=O)OCc2ccccc2)(c2ccccc2)c2ccccc2)n1>>Cc1cc(C)nc(OC(C(=O)O)C(OCCN)(c2ccccc2)c2ccccc2)n1,[Pd],CO,,[H][H],,val
US20030065031A1,COC(=O)CCNC(=O)c1ccc(C=O)cc1.Nc1ccc(C2=CCCCC2)cc1>>COC(=O)CCNC(=O)c1ccc(CNc2ccc(C3=CCCCC3)cc2)cc1,,CO,,[BH3-]C#N.[Na+],,val
US05223529,COc1cccc(NC(=O)NCC(=O)N(c2ccccc2)c2ccccc2)c1>>O=C(NCC(=O)N(c1ccccc1)c1ccccc1)Nc1cccc(O)c1,,ClCCl,ClCCl,BrB(Br)Br,,val
US20120040957A1,CCOC(=O)c1cnc2ccc(OC)nc2c1Cl>>CCOC(=O)c1cnc2ccc(OC)nc2c1,[Pd],CCO,,CCN(CC)CC,CCOC(C)=O,val
US04009205,CCN(CC)c1ccc(NC(C)=O)c(C)c1>>CCN(CC)c1ccc(N)c(C)c1,,O=S(=O)(O)O,,O,[Na+].[OH-],val
US05538986,C=CCC1(C=COC2CCCCO2)c2ccccc2CCc2ccccc21>>C=CCC1(CC=O)c2ccccc2CCc2ccccc21,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20070049603A1,CCOC(=O)c1cnc2c(OC)cccc2c1Cl>>CCOC(=O)c1cnc2c(OC)cccc2c1,[Pd],CC(=O)O,,,,val
US20080194609A1,CC(C)(C)[Si](C)(C)O[C@H]1CC2(CC2)Cc2nc(C3CCCC3)c([C@@H](O)c3ccc(C(F)(F)F)cc3)c(C3CCCCC3)c21.CCN(CC)S(F)(F)F>>CC(C)(C)[Si](C)(C)O[C@H]1CC2(CC2)Cc2nc(C3CCCC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCCCC3)c21,,Cc1ccccc1,,,,val
US20100305122A1,CC1(C#N)CCC(CNC(=O)OC(C)(C)C)CC1>>CC1(C#N)CCC(CN)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160272628A1,C=CCN1C(COC(C)=O)c2cc(Br)ccc2S1(=O)=O.O=C(OO)c1cccc(Cl)c1>>CC(=O)OCC1c2cc(Br)ccc2S(=O)(=O)N1CC1CO1,,ClCCl,,,,val
US20120309757A1,CCC(NC(=O)c1ccc2c(c1)c(C)c(C)n2Cc1ccc(-c2ccccc2C#N)cc1)c1ccccc1.C[Si](C)(C)N=[N+]=[N-]>>CCC(NC(=O)c1ccc2c(c1)c(C)c(C)n2Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1ccccc1,,Cc1ccccc1,,,,val
US05095014,CNC.Cc1cccc(Cl)c1OC1CN(C(=O)Cl)C1>>Cc1cccc(Cl)c1OC1CN(C(=O)N(C)C)C1,,C1CCOC1,O,,,val
US20060257987A1,CCOC(=O)CCc1ccc(OCC[C@H](C)Oc2ccc(Cl)cc2Oc2ccccc2F)cc1CC>>CCc1cc(OCC[C@H](C)Oc2ccc(Cl)cc2Oc2ccccc2F)ccc1CCC(=O)O,,CCO,,[Na+].[OH-],,val
US20070219210A1,CCOC(=O)c1cc(-c2ccc(OCc3ccccc3)cn2)n(-c2ccc(C)nc2)n1>>CCOC(=O)c1cc(-c2ccc(O)cn2)n(-c2ccc(C)nc2)n1,[Pd],CCO,CCOC(C)=O,[H][H],,val
US20100113803A1,COC(=O)C1NC(=O)C(C(=O)OC)C1c1c(OC)cc(OC)cc1OC>>COC(=O)C1NC(=O)CC1c1c(OC)cc(OC)cc1OC,,CN1CCCC1=O,,O,[Cl-].[Na+],val
US20160194332A1,C=C1C[C@H](NC(=O)OC(C)(C)C)Cn2c1c(-c1cnc3ccccc3c1)c1c(N)ncnc12.CC1=C[C@H](NC(=O)OC(C)(C)C)Cn2c1c(-c1cnc3ccccc3c1)c1c(N)ncnc12>>C=CC(=O)N[C@H]1C=C(C)c2c(-c3cnc4ccccc4c3)c3c(N)ncnc3n2C1,,CCO,O,Cl,,val
US20120202785A1,C[C@H](Nc1ncnc2[nH]cnc12)C(=S)Nc1ccc(F)cc1Nc1ccncn1>>C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2n1-c1ccncn1,,Cc1ccccc1,,,,val
US06492366B1,Cl.N#Cc1ccc2[nH]cc(CC3CCNC3)c2c1.O=c1[nH]c2ccccc2c(=O)n1CCCl>>Cl.N#Cc1ccc2[nH]cc(CC3CCN(CCn4c(=O)[nH]c5ccccc5c4=O)C3)c2c1,,CCO,CN(C)C=O,O=C([O-])O.[Na+],,val
US20120028919A1,CSc1ncc2ccc(-c3ccc(C)cc3NS(C)(=O)=O)n2n1.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(-c2ccc3cnc(S(C)=O)nn23)c(NS(C)(=O)=O)c1,,CN(C)C=O,,,,val
US20140343278A1,CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCn3c(=O)c(Br)cc4ccccc43)ccc21.OB(O)c1ccccc1>>CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCn3c(=O)c(-c4ccccc4)cc4ccccc43)ccc21,,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20100273819A1,COC(=O)C(C)(C)Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)Nc1cc(Cl)ccc12.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>COC(=O)C(C)(C)Oc1ccc(Cl)cc1C1CC(=S)NC(c2cc(F)ccc2C)C12C(=O)Nc1cc(Cl)ccc12,,C1CCOC1,Cc1ccccc1,,,val
US20160137584A1,CC(C)(C)OC(=O)C(C)(C)CCCCBr.CC(C)(C)OC(=O)C(C)(C)CCCCO>>CC(C)(CCCCOCCCCC(C)(C)C(=O)O)C(=O)O,,CN(C)C=O,,O,[H-].[Na+],val
US20100324056A1,CC(N)c1cnccn1.COC(=O)c1cc(-c2ccc(C)cc2)cc(N(C)C(=O)C(C)C)c1>>Cc1ccc(-c2cc(C(=O)NC(C)c3cnccn3)cc(N(C)C(=O)C(C)C)c2)cc1,,ClCCl,,On1nnc2ccccc21,,val
US05576335,CN(C)c1ccc(NC(=O)c2ccccc2[N+](=O)[O-])cc1>>CN(C)c1ccc(NC(=O)c2ccccc2N)cc1,[Pd],CCO,,,,val
US20090105275A1,CCOC(=O)C(CC(C)C)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCCN(Cc3ccc(-n4cccc4)cc3)C2)c1>>CC(C)CC(C(=O)O)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCCN(Cc3ccc(-n4cccc4)cc3)C2)c1,,CCO,,[K+].[OH-],,val
US20070197819A1,CC(=O)Oc1cc(OC(C)=O)cc(C(C)OC(C)=O)c1>>C=Cc1cc(OC(C)=O)cc(OC(C)=O)c1,,Cc1ccccc1,,,,val
US20140011800A1,CC(C)(C)OC(=O)NC1CNCC12CCC2.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)NC1CN(S(C)(=O)=O)CC12CCC2,,C1CCOC1,,CCN(CC)CC,,val
US05750542,CC(=O)c1ccc2c(c1O)CC(=O)N2.c1ccncc1>>Cc1noc2c3c(ccc12)NC(=O)C3,,CN(C)C=O,,,,val
US20160002177A1,Cn1cc(-c2cc(OCOCC[Si](C)(C)C)c3ncn(COCC[Si](C)(C)C)c(=O)c3c2)c(C(F)(F)F)n1>>Cn1cc(-c2cc(O)c3nc[nH]c(=O)c3c2)c(C(F)(F)F)n1,,O,O=CO,,,val
US20080076745A1,CC(C)(C)OC(=O)NCCC[C@@H](CC(=O)NC[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NCCC[C@H](N)CC(=O)NC[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C,[Pd],CCO,,,,val
US20050240021A1,COc1cc([N+](=O)[O-])ccc1-c1ccccn1>>COc1cc(N)ccc1-c1ccccn1,[Pd],CO,,,,val
US04551419,CC(=O)CCl.NCCSCCO.S=C=S>>Cc1csc(=S)n1CCSCCO,,CCO,,CCN(CC)CC,,val
US20140171405A1,C1=COCCC1.Clc1ncc2cn[nH]c2n1>>Clc1ncc2cnn(C3CCCCO3)c2n1,,C1CCOC1,,CS(=O)(=O)O,,val
US20030013754A1,CC(=O)c1cccc(N)c1.CCOC(=O)C(CC(=O)c1ccccc1)C(C)=O>>CCOC(=O)c1cc(-c2ccccc2)n(-c2cccc(C(C)=O)c2)c1C,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090181942A1,CCOC(=O)C[C@H]1S[C@H](c2cccc(Cl)c2Cl)c2cc(Cl)ccc2NC1=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)C[C@H]1S[C@H](c2cccc(Cl)c2Cl)c2cc(Cl)ccc2NC1=S,,Cc1ccccc1,,,,val
US05821245,NC(CCl)=NO.O=C(Cl)c1ccc(Cl)cc1>>ClCc1noc(-c2ccc(Cl)cc2)n1,,CC(C)=O,,O=C([O-])O.[Na+],,val
US20130012544A1,BrCC1CC1.COc1ccc(C2=NN(C3CCN(C(=O)CN4C(=O)CCC4=O)CC3)C(=O)C2(C)C)cc1O>>COc1ccc(C2=NN(C3CCN(C(=O)CN4C(=O)CCC4=O)CC3)C(=O)C2(C)C)cc1OCC1CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110251165A1,C=CCOCCCCc1ccccc1.OO>>OCCCOCCCCc1ccccc1,,C1CCOC1,,B1C2CCCC1CCC2,[Na+].[OH-],val
US20100076027A1,CC(C)(C)OC(=O)C1(Oc2ccc(NC(=O)C(c3c4c(nn3-c3ccc(Cl)cc3)CCCC4)C3CCCCC3)c(F)c2)CC1>>O=C(Nc1ccc(OC2(C(=O)O)CC2)cc1F)C(c1c2c(nn1-c1ccc(Cl)cc1)CCCC2)C1CCCCC1,,O=CO,,,,val
US04096267,C=C(C(=O)c1ccc(OC)c(Cl)c1Cl)c1ccc(Br)cc1>>COc1cc2c(c(Cl)c1Cl)C(=O)C(c1ccc(Br)cc1)C2,,ClCCl,,O=S(=O)(O)O,,val
US20110112085A1,C[Si](C)(C)CCOCCl.Cc1nc2cc(Br)cnc2[nH]1>>Cc1nc2cc(Br)cnc2n1COCC[Si](C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20060024330A1,CC(=O)N1CC(=O)Nc2ccccc21.Fc1ccc(CBr)cc1>>CC(=O)N1CC(=O)N(Cc2ccc(F)cc2)c2ccccc21,,CN(C)C=O,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20100152166A1,COC(=O)OC.COC(=O)c1c[nH]c2cc(Br)ccc12>>COC(=O)c1cn(C)c2cc(Br)ccc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130090386A1,N[C@@H]1C[C@H]1c1ccc(OCc2cccc(Br)c2)cc1.O=CCC1CCCCC1>>Brc1cccc(COc2ccc([C@@H]3C[C@H]3NCCC3CCCCC3)cc2)c1,,ClCCCl,,[BH4-].[Na+],,val
US20090149651A1,CC1(C)OB(c2cncc(F)c2)OC1(C)C.Nc1c(-c2ncccn2)cc(Br)cc1[N+](=O)[O-]>>Nc1c(-c2ncccn2)cc(-c2cncc(F)c2)cc1[N+](=O)[O-],,O,,,,val
US20080255105A1,CCOC(=O)c1ccc(-c2cc(C#N)ccc2C)cc1>>Cc1ccc(C#N)cc1-c1ccc(C(=O)O)cc1,,CCO,,[Na+].[OH-],,val
US04551171,NO.O=Cc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-]>>O=[N+]([O-])c1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1C=NO,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US08829007B2,COCC1CO1.Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(N[C@H]4CCCNC4)n3)c3cc(Cl)cnc32)cc1>>COC([C@H](C)O)N1CCCCC1Nc1nc(-c2cn(S(=O)(=O)c3ccc(C)cc3)c3ncc(Cl)cc23)ncc1F,,CCO,,,,val
US20040063946A1,Cc1cccc(-c2nc(N)sc2-c2ccnc(NCc3ccccc3)c2)c1.O=C(Cl)c1cccnc1>>Cc1cccc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccnc(NCc3ccccc3)c2)c1,CN(C)c1ccncc1,CC(=O)N(C)C,,Cl,O=C([O-])O.[Na+],val
US20080153810A1,Nc1n[nH]c2ccc([N+](=O)[O-])cc12.O=Cc1nccs1>>O=[N+]([O-])c1ccc2[nH]nc(NCc3nccs3)c2c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20100172867A1,CC(C)(C)OC(=O)NC1Cc2ccccc2N(Cc2ccc(F)cc2F)C1.O=C(O)C(F)(F)F>>NC1Cc2ccccc2N(Cc2ccc(F)cc2F)C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20120094996A1,CC1(C)OB(c2cnc(N)c(C(F)(F)F)c2)OC1(C)C.COc1cc(-c2nn3c(I)cnc3s2)ccc1OC1CCN(C(=O)OC(C)(C)C)CC1>>COc1cc(-c2nn3c(-c4cnc(N)c(C(F)(F)F)c4)cnc3s2)ccc1OC1CCN(C(=O)OC(C)(C)C)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US05616456,CCN(CC)CC.Nc1cnccn1.S=C=S>>CC[NH+](CC)CC.S=C([S-])Nc1cnccn1,,CCCCCC,,CCOC(C)=O,,val
US20090023789A1,O=C(O)C12CC3CC(CC1C3)C2.O=S(Cl)Cl>>O=C(Cl)C12CC3CC(CC1C3)C2,,Cc1ccccc1,,,,val
US20110009364A1,Brc1cnc2c(c1)CCN2.CI>>CN1CCc2cc(Br)cnc21,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20150065705A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CC=C(c2ccc(F)cc2)C(N)C1>>CC(=O)NC1CN(C(=O)OC(C)(C)C)CC=C1c1ccc(F)cc1,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,,val
US05288720,CCCCc1nc(=O)c2cc(C=O)ccc2[nH]1.CN1CCCC1=O>>CCCCc1nc(=O)c2cc(C(O)C3CCN(C)C3=O)ccc2[nH]1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20130203745A1,Cc1ccccc1S(=O)(=O)Cl.[F-]>>Cc1ccccc1S(=O)(=O)F,,CC#N,,O,,val
US20070270383A1,CC(C)CSCC(C)C.CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1>>CC(C)CSC(O[C@@H](C[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)N(C)Cc1csc(C(C)C)n1)C(C)C)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(C)C,,CC#N,CCOC(C)=O,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20050240021A1,CCC(O)c1ccc(-c2ccccn2)c(OC)c1>>CCC(=O)c1ccc(-c2ccccn2)c(OC)c1,,ClCCl,O,CCN(CC)CC,CS(C)=O,val
US07109225B2,Cc1oc(C(C)(C)C)[n+]([O-])c1C.ClCCl>>Cc1oc(C(C)(C)C)nc1CCl,,ClCCl,,O=P(Cl)(Cl)Cl,,val
US20060287303A1,CI.COc1ccc(Cl)cc1C1(O)CCN(C(=O)OC(C)(C)C)CC1>>COc1ccc(Cl)cc1C1(OC)CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US20110052674A1,CC(C)(C)OC(=O)NCC(=O)OCCCCO[N+](=O)[O-]>>NCC(=O)OCCCCO[N+](=O)[O-],,ClCCl,,,,val
US20120208817A1,CCOc1cc(C=O)cc([N+](=O)[O-])c1O.COCOc1ccc(C(=O)Cc2ccccc2)cc1.NC(N)=O>>CCOc1cc(C2NC(=O)NC(c3ccc(O)cc3)=C2c2ccccc2)cc([N+](=O)[O-])c1O,,CCO,,Cl,,val
US20060167012A1,Br.Cc1cc(N)ccc1OC(F)F>>Cc1cc(Br)ccc1OC(F)F,[Cu]Br,O,,O=N[O-].[Na+],,val
US20110021522A1,COc1cccc2cc(C(=O)O)c(=O)oc12.N#Cc1ccc(-c2cccc(N)c2)cc1F>>COc1cccc2cc(C(=O)Nc3cccc(-c4ccc(C#N)c(F)c4)c3)c(=O)oc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080234276A1,Nc1nnc2ccc(NC(=O)Nc3cnccn3)cc2n1>>O=C(Nc1ccc2nncnc2c1)Nc1cnccn1,,CN(C)C=O,,CC(C)CCON=O,,val
US05250547,CC1=C(n2ccccc2=O)c2cc([N+](=O)[O-])ccc2OC1(C)C.O=C1CCC(=O)N1Br>>CC1(C)Oc2ccc([N+](=O)[O-])cc2C(n2ccccc2=O)=C1CBr,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,ClCCl,,val
US05466697,CCI.O=c1[nH]cc(-c2cccc(Cl)c2)c2ncccc12>>CCn1cc(-c2cccc(Cl)c2)c2ncccc2c1=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070060596A1,CCOC(=O)c1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1>>O=C(O)c1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1,,CCO,,[Na+].[OH-],,val
US04426381,O=C(O)c1c2n(c3cc(N4CCNCC4)c(F)cc3c1=O)CCS2.O=Cc1ccccc1C=O>>O=C1OC(N2CCN(c3cc4c(cc3F)c(=O)c(C(=O)O)c3n4CCS3)CC2)c2ccccc21,,CN(C)C=O,,,,val
US20080214641A1,CI.COc1cc(Br)ccc1S>>COc1cc(Br)ccc1SC,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20020120148A1,CCCBr.Oc1ccc2c(c1)CC(NCc1ccccc1)CCC2>>CC(C)Oc1ccc2c(c1)CC(NCc1ccccc1)CCC2,,CN(C)C=O,,[H-].[Na+],,val
US20140135306A1,CC(=O)c1ccc(I)cc1.COc1cccc([Mg]Br)c1>>COc1cccc(C(C)(O)c2ccc(I)cc2)c1,,C1CCOC1,,,,val
US20090137595A1,COCCOc1cc(C(=O)OC)n(C)n1>>COCCOc1cc(C(=O)O)n(C)n1,,CO,,[Na+].[OH-],,val
US06476030B1,Cc1ccc(S(=O)(=O)Oc2n[nH]c(C=O)c2-c2ccccc2F)cc1.NNC(=O)c1ccccc1F>>Cc1ccc(S(=O)(=O)OC2=C(c3ccccc3F)C(=NNC(=O)c3ccccc3F)N=N2)cc1,,Cc1ccccc1C,,,,val
US20020099208A1,N#CCCCn1c(CO)nc2ccccc21.NO>>N=C(CCCn1c(CO)nc2ccccc21)NO,,CCO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20160068532A1,CCOC(=O)CCCc1cc2c(-c3ccnc(C)c3)nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c2cc1N>>Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc4c(cc23)CCCC(=O)N4)ccn1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20090253687A1,O=C1COc2ccc(C3=Cc4ccccc4SC3c3ccc([N+](=O)[O-])cc3)cc2N1>>Nc1ccc(C2Sc3ccccc3C=C2c2ccc3c(c2)NC(=O)CO3)cc1,[Zn],C1CCOC1,,CC(=O)O,,val
US20100016319A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccnc(Cl)n2)cc1.OC[C@@H]1CCCN1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccnc(N3CCC[C@H]3CO)n2)cc1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US05622976,N#Cc1ccc(-c2nc(C=O)no2)cc1.O=C(O)CC(=O)O>>N#Cc1ccc(-c2nc(/C=C/C(=O)O)no2)cc1,,c1ccncc1,,C1CCNCC1,,val
US20140275080A1,CC(C)(C)C(N)=O.Cn1cc(-c2cc(Oc3ccc(N)nc3)ccn2)cn1.O=C(Cl)C(=O)Cl>>Cn1cc(-c2cc(Oc3ccc(NC(=O)NC(=O)C(C)(C)C)nc3)ccn2)cn1,,C1CCOC1,ClCCCl,c1ccncc1,,val
US20140206663A1,C[C@@H]1C(=O)NN=C2COc3cc(C4CC4)c(NC4CN(C(=O)OC(C)(C)C)C4)cc3N21.O=C(O)C(F)(F)F>>C[C@@H]1C(=O)NN=C2COc3cc(C4CC4)c(NC4CNC4)cc3N21.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20140296266A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H](Cc1cc(F)cc(F)c1)c1ncc(Br)cc1Br>>CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)c1ncc(Br)cc1Br,,ClCCl,,,,val
US20150210682A1,CCOC=C(C(C)=O)C(=O)OCC.COc1cc2c(c(Cl)c1OC)CC(C)N=C2>>CCOC(=O)C1=CN2C(C)Cc3c(cc(OC)c(OC)c3Cl)C2CC1=O,,CCO,,,,val
US20110021537A1,O=C(O)CNC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1.O=C(OCc1ccccc1)N1CCNCC1>>O=C(NCC(=O)N1CCN(C(=O)OCc2ccccc2)CC1)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04889855,N#Cc1cccc2c(N)c([N+](=O)[O-])ccc12>>N#Cc1cccc2c(N)c(N)ccc12,[Ni],CCO,CCOC(C)=O,,,val
US20070299086A1,COC(=O)c1ccc(-c2ccc(Cl)cc2)cc1OC>>COc1cc(-c2ccc(Cl)cc2)ccc1C(=O)O,,C1CCOC1,,O,[Li+].[OH-],val
US04493832,CCCCCCCCCCCCOCC(O)COC(c1ccccc1)(c1ccccc1)c1ccccc1.COC(=O)Cl>>CCCCCCCCCCCCOCC(COC(c1ccccc1)(c1ccccc1)c1ccccc1)OC(=O)OC,,ClCCl,,c1ccncc1,,val
US20080161371A1,CC(C)(C)[S@](=O)N[C@@H](c1cnc(NC(=O)C2(c3ccc4c(c3)OCO4)CC2)s1)c1ccccc1Cl>>N[C@H](c1cnc(NC(=O)C2(c3ccc4c(c3)OCO4)CC2)s1)c1ccccc1Cl,,CO,,C1COCCO1,Cl,val
US20070167503A1,CCOCCOCC.Oc1cc(Br)c2oc(-c3ccc(O)c(F)c3)nc2c1>>C=Cc1cc(O)cc2nc(-c3ccc(O)c(F)c3)oc12,Cc1ccccc1[P](c1ccccc1C)(c1ccccc1C)[Pd](Cl)(Cl)[P](c1ccccc1C)(c1ccccc1C)c1ccccc1C,,,,,val
US20130079339A1,CN(C)CCOc1cc(C(F)(F)F)ccc1CN.Nc1cccc2c1OCC(=O)N2.O=C(n1ccnc1)n1ccnc1>>CN(C)CCOc1cc(C(F)(F)F)ccc1CNC(=O)Nc1cccc2c1OCC(=O)N2,,C1CCOC1,CN(C)C=O,,,val
US20110015119A1,CNC(=O)Cc1ccc([N+](=O)[O-])cc1>>CNCCc1ccc([N+](=O)[O-])cc1,,C1CCOC1,,,,val
US20070191370A1,Nc1nc(Cl)cc(Cl)n1.SCc1ccccc1>>Nc1nc(Cl)cc(SCc2ccccc2)n1,,C1CCOC1,ClCCl,[H-].[Na+],,val
US20130331378A1,COC(=O)c1cccc(Cc2c(-c3ccccc3)nn3c([Si](C)(C)C)cccc23)c1>>COC(=O)c1cccc(Cc2c(-c3ccccc3)nn3ccccc23)c1,,C1CCOC1,,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US05116911,C=C(C)C(=O)Cl.OCCCCCCn1c2ccccc2c2ccccc21>>C=C(C)C(=O)OCCCCCCn1c2ccccc2c2ccccc21,,ClCCl,,CCN(CC)CC,,val
US04764519,Cc1cc(Br)cnc1CCCCNc1ncc(Cc2cccnc2)cc1[N+](=O)[O-]>>Cc1cc(Br)cnc1CCCCNc1ncc(Cc2cccnc2)cc1N,[Ni],CO,,NN,O,val
US20070167443A1,Cc1ccc2[nH]cc(C(=O)c3ccc(C)c(C)c3)c(=O)c2n1.Cc1cccc(CBr)n1>>Cc1cccc(Cn2cc(C(=O)c3ccc(C)c(C)c3)c(=O)c3nc(C)ccc32)n1,,CN(C)C=O,,[H-].[Na+],,val
US04277470,C=CC(=O)OC.O=[N+]([O-])C1C2C=CC(CC2)C1c1ccccc1>>COC(=O)CCC1([N+](=O)[O-])C2C=CC(CC2)C1c1ccccc1,,CC(C)(C)O,,C1COCCO1,,val
US20070105919A1,Cc1ncccc1C(=O)c1sc(NC(=O)OC(C)(C)C)nc1-c1ccco1>>Cc1ncccc1C(=O)c1sc(N)nc1-c1ccco1,,O=C(O)C(F)(F)F,,,,val
US20150266881A1,Cl.N[C@@H]1C[C@H]1c1cccc(C(=O)NC2CCOCC2)c1.O=C1CCC1>>Cl.O=C(NC1CCOCC1)c1cccc([C@@H]2C[C@H]2NC2CCC2)c1,,CC(=O)O,CO,O=C([O-])O.[Na+],,val
US20040259877A1,CC(=O)c1ccc(O)c(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1>>CC(O)c1ccc(O)c(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1,,CCO,,Cl,[BH4-].[Na+],val
US20120322791A1,CC(=O)OC(C)=O.NNc1ccc(Br)cn1>>CC(=O)NNc1ccc(Br)cn1,,ClCCl,,,,val
US20060111416A1,COc1ccc(N)c(N)c1.O=C(O)CO>>COc1ccc2[nH]c(CO)nc2c1,,Cl,,[Na+].[OH-],,val
US05753671,CC1(CCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)OCCO1>>CC(=O)CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1,,C1CCOC1,,Cl,,val
US20130142737A1,CC(CO)CCC(C)(C)C.Cc1cc(CCl)c(O)c(-n2nc3ccccc3n2)c1>>Cc1cc(COCC(C)CCC(C)(C)C)c(O)c(-n2nc3ccccc3n2)c1,,C1COCCO1,,[H-].[Na+],,val
US20040132727A1,COc1cc2nccc(Oc3ccc(NC(=O)COc4c(OC)cccc4OC)cc3)c2cc1OC>>COc1cc2nccc(Oc3ccc(NCCOc4c(OC)cccc4OC)cc3)c2cc1OC,,C1CCOC1,,Cl,[Na+].[OH-],val
US20150152096A1,CCOC(=O)C(CC1COCCN1Cc1ccccc1)C(=O)OCC>>CCOC(=O)C(CC1COCCN1)C(=O)OCC,[Pd],,,,,val
US20100331341A1,CN(C)C(=O)c1cc2cccc(N3CCNCC3)c2o1.COc1cccc(CCOS(=O)(=O)c2ccc(C)cc2)n1>>COc1cccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110003793A1,Clc1cc(I)ccn1.OCc1ccc(Cl)cc1>>Clc1ccc(COc2ccnc(Cl)c2)cc1,[Cu]I,Cc1ccccc1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060293337A1,CCOC(=O)CN[C@H]1CCN(c2ccc3c(NC(=O)CC4CCCCC4)c(Cl)ccc3n2)C1>>O=C(O)CN[C@H]1CCN(c2ccc3c(NC(=O)CC4CCCCC4)c(Cl)ccc3n2)C1,,CO,,Cl,[Na+].[OH-],val
US20090281086A1,CC(Cl)c1ccc(F)c(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1.NC(=O)c1sccc1O>>CC(Oc1ccsc1C(N)=O)c1ccc(F)c(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04835175,COC(=O)c1cc2c(C(=O)CN)ccc(O)c2[nH]1.Cl>>COC(=O)c1cc2c(C(O)CN)ccc(O)c2[nH]1.Cl,[Pd],CO,,,,val
US20120028954A1,N#Cc1ccc(CN2CCC(C(N)=O)CC2)cc1.O=C(c1ccc(Br)nc1)N1CCN(Cc2ccc(F)cc2)CC1>>N#Cc1ccc(CN2CCC(C(=O)Nc3ccc(C(=O)N4CCN(Cc5ccc(F)cc5)CC4)cn3)CC2)cc1,[Cu]I,Cc1ccccc1,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US04515793,O=C(CN1CCN(c2ccc(CO)c(Cl)c2)CC1)c1cccc([N+](=O)[O-])c1>>Nc1cccc(C(=O)CN2CCN(c3ccc(CO)c(Cl)c3)CC2)c1,[Ni],C1CCOC1,,[H][H],,val
US20090137595A1,N#CC1(c2cccc(C(=O)Nc3cccc(Oc4ccc5nc(N)cn5n4)c3)c2)CC1.O=C(Cl)CCl>>N#CC1(c2cccc(C(=O)Nc3cccc(Oc4ccc5nc(NC(=O)CCl)cn5n4)c3)c2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20130172556A1,CCc1ccc(-c2ccc(Cl)cc2)cc1C(=O)C(=O)O.O=S(Cl)Cl>>CCc1ccc(-c2ccc(Cl)cc2)cc1C(=O)C(=O)Cl,CN(C)C=O,Cc1ccccc1,,,,val
US04227000,CCOC(=O)C(C=O)Cc1ccnc(OC)c1.N=C(N)N[N+](=O)[O-]>>COc1cc(-c2cnc(N[N+](=O)[O-])[nH]c2=O)ccn1,,CC(=O)O,,C[O-].[Na+],,val
US20050187247A1,CN1CCN(C2CCNCC2)CC1.COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1F>>COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1N1CCC(N2CCN(C)CC2)CC1,,CN1CCCC1=O,,,,val
US20030153753A1,COc1cc(C[C@H]2NC(=O)CN(Cc3ccccc3)C2=O)ccc1C>>COc1cc(C[C@@H]2CN(Cc3ccccc3)CCN2)ccc1C,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20070004725A1,CC(=O)N1CCN(C(=O)C(Cc2ccc(Oc3ccc(CCC(=O)NOCc4ccccc4)cc3)cc2)NC(=O)OC(C)(C)C)CC1>>CC(=O)N1CCN(C(=O)C(Cc2ccc(Oc3ccc(CCC(=O)NO)cc3)cc2)NC(=O)OC(C)(C)C)CC1,[Pd],CO,,[H][H],,val
US20150148344A1,Cc1noc(C)c1-c1cc(S(=O)(=O)NC2CCCC2)c2ccc(Cl)nc2c1.OB(O)C1CC1>>Cc1noc(C)c1-c1cc(S(=O)(=O)NC2CCCC2)c2ccc(C3CC3)nc2c1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20090233979A1,COC(=O)c1cc(Br)c(Oc2ccc([N+](=O)[O-])cc2)c(Br)c1>>COC(=O)c1cc(Br)c(Oc2ccc(N)cc2)c(Br)c1,O=[Pt]=O,CCOC(C)=O,,,,val
US04555581,C=CC(=O)OCCCC.O.c1ccoc1>>CCCCOC(=O)C1CC2C=CC1O2,,O,,Cl[Sn](Cl)(Cl)Cl,,val
US04348320,CC(=O)OC(C)CC1CC(=O)N1[Si](C)(C)C(C)(C)C>>CC(=O)OC(C)CC1CC(=O)N1,,CO,Cl,,,val
US04232035,CN(SSc1ccccc1)C(=O)F.CN1C(=O)C(C)(C)SC1=NO>>CN(SSc1ccccc1)C(=O)ON=C1SC(C)(C)C(=O)N1C,,C1COCCO1,,CCN(CC)CC,,val
US20110230518A1,CC(C)(C)OC(=O)CCN1CCc2ccc(C(N)=NO)cc2C1.CCC1CCCCN1c1ccc(C(=O)O)cc1COC>>CCC1CCCCN1c1ccc(-c2nc(-c3ccc4c(c3)CN(CCC(=O)OC(C)(C)C)CC4)no2)cc1COC,,CCOC(C)=O,,Cl,,val
US20080027068A1,COC(=O)c1ccc(C(=O)O)cc1N.O=S(=O)(O)O>>COC(=O)c1ccc(C(=O)O)cc1O,,CC(=O)O,Cl,O=N[O-].[Na+],,val
US20100210635A1,O=C(O)COc1ccccc1Br.c1ccc(C[C@@H]2CN(Cc3ccccc3)CCN2)cc1>>O=C(COc1ccccc1Br)N1CCN(Cc2ccccc2)C[C@H]1Cc1ccccc1,,CCOCC,ClCCl,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20140343065A1,CC(C)(C)NC(=O)c1cc(Cl)ccn1.CI>>Cc1c(Cl)ccnc1C(=O)NC(C)(C)C,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20160257662A1,CN1CCNCC1.N[C@@H]1C[C@H]1c1ccc(F)cc1.O=C(N[C@@H](CCCCN[C@@H]1C[C@H]1c1ccccc1)C(=O)N1CCCC1)c1ccccc1.O=C(O)CCC[C@H](NC(=O)c1ccc(F)cc1)C(=O)O>>CN1CCN(C(=O)[C@H](CCCCN[C@@H]2C[C@H]2c2ccc(F)cc2)NC(=O)c2ccc(F)cc2)CC1,,C1CCOC1,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20100197665A1,N#Cc1cc(S(=O)(=O)c2ccccc2)ccc1N.O=N[O-]>>Nc1n[nH]c2ccc(S(=O)(=O)c3ccccc3)cc12,,Cl,O,Cl[Sn]Cl,,val
US20100016306A1,CN(C)C=O.Fc1ccc2[nH]ccc2c1.O>>COC(=O)c1c[nH]c2ccc(F)cc12,,CN(C)C=O,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US05919779,COc1ccc(CN)cc1.Clc1ncccc1-c1ncsc1-c1cccnc1Cl>>COc1ccc(CNc2ncccc2-c2ncsc2-c2cccnc2Cl)cc1,,Cc1ccccc1C,,,,val
US20100197681A1,NC1CCCC1.O=C(Nc1nc2cccc(Br)n2n1)c1ccco1>>O=C(Nc1nc2cccc(NC3CCCC3)n2n1)c1ccco1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20160024053A1,CS(=O)c1cn(-c2ncc(-c3ccccn3)cn2)c2cc(C(=O)N3C[C@@H]4C[C@H]3CN4C(=O)OC(C)(C)C)ccc12>>CS(=O)c1cn(-c2ncc(-c3ccccn3)cn2)c2cc(C(=O)N3C[C@@H]4C[C@H]3CN4)ccc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070060754A1,CC(C)C(=O)Cl.CCCn1c(COCC)nc2c(N)nc3ccc(OCCCCCCN)cc3c21>>CCCn1c(COCC)nc2c(N)nc3ccc(OCCCCCCNC(=O)C(C)C)cc3c21,,ClCCl,,CCN(CC)CC,O,val
US20160251340A1,CC[C@@](C)(N)C(=O)Nc1ccc(Oc2cccc3c2C2CC2CO3)nc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC[C@@]1(C)NC(=O)N(c2ccc(Oc3cccc4c3C3CC3CO4)nc2)C1=O,,ClCCl,,,,val
US04820703,CCCCc1ccc(CCc2cc3c(s2)NC(=O)CN=C3c2ccccc2Cl)cc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCCCc1ccc(CCc2cc3c(s2)NC(=S)CN=C3c2ccccc2Cl)cc1,,Cc1ccccc1,,,,val
US20160039838A1,CCOc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1[N+](=O)[O-]>>CCOc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1N,[Ni],CO,,,,val
US20120202788A1,CS(=O)(=O)c1ncnc2nc(-c3c(Cl)cccc3Cl)sc12.CSc1ncnc2nc(-c3c(Cl)cccc3Cl)sc12.O=C(OO)c1cccc(Cl)c1>>O=C(Nc1ncnc2nc(-c3c(Cl)cccc3Cl)sc12)C1CC1,,ClCCl,,,,val
US20120028918A1,CCOC(=O)C(C(=O)OCC)c1ccc(Br)cn1>>O=C(O)Cc1ccc(Br)cn1,,CO,,[Na+].[OH-],,val
US20070135363A1,C[C@@]1(O)[C@H](OCc2ccc(Cl)cc2Cl)[C@@H](COCc2ccc(Cl)cc2Cl)O[C@H]1N1C=C2CCC3=C2C(=N1)C=NNC3>>C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C=C2CCC3=C2C(=N1)C=NNC3,,ClCCl,,ClB(Cl)Cl,,val
US20030176418A1,ClCCCI.O=C1COc2cc(Cl)ccc2N1>>O=C1COc2cc(Cl)ccc2N1CCCCl,,CCCCCCC,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050233988A1,CC(C)(C)O.O=C(O)c1cc(Br)ccc1Cl>>CC(C)(C)OC(=O)c1cc(Br)ccc1Cl,,CCOCC,CN(C)C=O,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20120302540A1,CC(C)N1CC(c2ccc(F)cc2)C2(CCCN(C(=O)[C@@H](Cc3cn(C)c4ccccc34)NC(=O)C(C)(C)NC(=O)OC(C)(C)C)C2)C1=O>>CC(C)N1CC(c2ccc(F)cc2)C2(CCCN(C(=O)[C@@H](Cc3cn(C)c4ccccc34)NC(=O)C(C)(C)N)C2)C1=O,,ClCCl,,CO,O=C(O)C(F)(F)F,val
US20100305096A1,CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1.OC1CN(C2CCNCC2)C1>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(N4CC(O)C4)CC3)n(C)c2n1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160024057A1,CC1(C)CC(Cn2ncc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CN1.O=S(=O)(Cl)c1ccccc1>>CC1(C)CC(Cn2ncc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CN1S(=O)(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20020156081A1,BrC1CCCC1.Nc1ncnc2[nH]nc(-c3ccc(Oc4ccccc4)cc3)c12>>Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCC1,,CC(=O)N(C)C,,[H-].[Na+],,val
US20030069307A1,CCCCCCN=C=O.NCCc1ccc(O)c(O)c1>>CCCCCCNC(=O)NCCc1ccc(O)c(O)c1,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US20040167123A1,CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(N)ccc3N2)c(O)c2cccnc21.COC(=O)[C@@H]1CCCN1S(=O)(=O)Cl>>COC(=O)[C@@H]1CCCN1S(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(c1c(O)c3cccnc3n(CCC(C)C)c1=O)N2,,CC#N,,CCN(CC)CC,,val
US20150191483A1,Fc1ccc(S)cc1Br.OC(c1ccc(CBr)cc1)(C(F)(F)F)C(F)(F)F>>OC(c1ccc(CSc2ccc(F)c(Br)c2)cc1)(C(F)(F)F)C(F)(F)F,,C1CCOC1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20050119325A1,CC(C)=O.Cl.Cl.Nc1ccc2cc(C(=O)N[C@H]3CN4CCC3CC4)sc2c1>>CC(C)Nc1ccc2cc(C(=O)N[C@H]3CN4CCC3CC4)sc2c1.Cl.Cl,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130203815A1,CCOC(=O)C1C(=O)NCC1c1c(OC)cc(OC)cc1OC.COS(=O)(=O)OC>>CCOC(=O)C1C(=O)N(C)CC1c1c(OC)cc(OC)cc1OC,CO,CN(C)C=O,,[H-].[Na+],,val
US04073791,NN=c1ccn(-c2ccc(Cl)cc2)cc1.O=Cc1ccc(Cl)cc1.O=S(=O)(O)F>>Clc1ccc(C=NN=c2ccn(-c3ccc(Cl)cc3)cc2)cc1.O=S(=O)(O)F,,CCO,,O,,val
US05001159,CC(C)COc1ccccc1N.O=C(Cl)CCCCl>>CC(C)COc1ccccc1NC(=O)CCCCl,,CCOCC,,O=C([O-])[O-].[K+].[K+],,val
US20080153850A1,CCOC(=O)CCl.O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(-c2ccc(O)cc2)ccc1Cl>>CCOC(=O)COc1ccc(-c2ccc(Cl)c(C(=O)NCC34CC5CC(CC(C5)C3)C4)c2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150291563A1,CC(C)(C)OC(=O)N1CCCN(c2cccc(C3CC(C(F)(F)C(F)(F)F)=NN3c3ccccc3Cl)c2)CC1.Cl>>Cl.FC(F)(F)C(F)(F)C1=NN(c2ccccc2Cl)C(c2cccc(N3CCCNCC3)c2)C1,,CCOC(C)=O,,,,val
US20060135530A1,CC(C)(C)OC(=O)CBr.Cc1ccc(-c2c(C#N)c(CC(C)C)nc3ccc(OCCO)cc23)cc1>>Cc1ccc(-c2c(C#N)c(CC(C)C)nc3ccc(OCCOCC(=O)OC(C)(C)C)cc23)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20020147342A1,O=S(Cl)Cl.OCCc1ccc(OCCN2CCCCC2)cc1>>ClCCc1ccc(OCCN2CCCCC2)cc1,,C1CCOC1,,,,val
US20150025071A1,CSc1nc2c(c(=O)[nH]1)CCCC2.Clc1ccc(N2CCNCC2)cc1>>O=c1[nH]c(N2CCN(c3ccc(Cl)cc3)CC2)nc2c1CCCC2,,CC(C)CCO,,,,val
US06329381B1,Fc1ccc(CCl)cc1.Nc1nc(Cl)nc2nc[nH]c12>>Nc1nc(Cl)nc2c1ncn2Cc1ccc(F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060030595A1,CSc1nccc(C(Cl)c2cccc(C#N)c2)n1.c1cncc(Cc2cccnc2)c1>>CSc1nccc(C(c2cccc(C#N)c2)C(c2cccnc2)c2cccnc2)n1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US04211867,CI.NC(=S)NC1c2ccccc2-c2ccccc21>>CSC(=N)NC1c2ccccc2-c2ccccc21.I,,CC(C)=O,,CCOCC,,val
US20150175562A1,CCOC(=O)c1ncoc1-c1ccc(S(=O)(=O)NC(C)(C)C)c2ccccc12>>CC(C)(C)NS(=O)(=O)c1ccc(-c2ocnc2C(=O)O)c2ccccc12,,CCO,,[Na+].[OH-],,val
US05631257,C=CCI.CN1CCCN(c2nc3ccccc3o2)CC1>>C=CC[N+]1(C)CCCN(c2nc3ccccc3o2)CC1.[I-],,ClCCl,,,,val
US04094886,CCOC(=O)CC1(C(=O)OC)C(=O)CCC1CSc1ccccc1>>CCOC(=O)CC1C(=O)CCC1CSc1ccccc1,,CN(C)C=O,,[I-].[Li+],,val
US04985419,CC(C)CCNC(=S)c1ccc2c(c1)N(C(C)CN1CCC[C@H]1CO)c1ccccc1S2.Cl>>CC(C)CCNC(=S)c1ccc2c(c1)N(C(C)CN1CCC[C@H]1CO)c1ccccc1S2.Cl,,CCOCC,,,,val
US20140038989A1,CCOC(=O)c1cnn2c(C(F)(F)F)cc(-c3ccc(CC)cc3)nc12>>CCOC(=O)c1cnn2c1N[C@@H](c1ccc(CC)cc1)C[C@H]2C(F)(F)F,,CO,,[BH4-].[Na+],,val
US20110003786A1,CCN(CC)C(=N)N.CN(C)C=Nc1nc2c(s1)C(=O)/C(=C/N(C)C)CC2>>CCN(CC)c1ncc2c(n1)-c1sc(N)nc1CC2,,COCCO,,[Na+].[OH-],,val
US20020193367A1,CCCNC.Cc1cc([N+](=O)[O-])c(NC(=O)OC(C)(C)C)cc1Cl>>CCCN(C)c1cc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])cc1C,,CS(C)=O,,,,val
US04668682,CN(C)CCN.COc1ccc(OC)c(CC(=O)Nc2ccccc2C(=O)O)c1>>COc1ccc(OC)c(Cc2nc3ccccc3c(=O)n2CCN(C)C)c1,,Cc1ccccc1C,,,,val
US20080262028A1,CCOC(=O)[C@@H](Cc1ccc(N)nc1)c1cn(Cc2cc(-c3ccc(Cl)s3)on2)cn1>>Nc1ccc(C[C@H](C(=O)O)c2cn(Cc3cc(-c4ccc(Cl)s4)on3)cn2)cn1,,Cl,,O,,val
US06936602B1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3)cc1.O=CC1CC1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3CC2CC2)cc1,,ClCCCl,O,O=C([O-])O.[Na+],,val
US20010025045A1,COC(=O)c1ccc(OCc2ccccc2)cc1OC.ClCl>>COc1cc(OCc2ccccc2)c(Cl)cc1C(=O)O,,CC(=O)O,,,,val
US20070197628A1,CCOC(=O)/C=C(\C)CP(=O)(OCC)OCC.O=Cc1ccc(Cl)cc1Cl>>CCOC(=O)C=C(C)C=Cc1ccc(Cl)cc1Cl,,C1CCOC1,CN1CCCN(C)C1=O,[Li]CCCC,,val
US20100256101A1,COC(=O)/C=C/c1ccc(C(F)(F)F)nc1C>>Cc1nc(C(F)(F)F)ccc1/C=C/C(=O)O,,CO,,[Na+].[OH-],,val
US20060154931A1,CNN.c1ccc2nc(COc3ccc(-c4[nH]ncc4-c4ccncc4)cc3)ccc2c1>>Cn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ccccc4n3)cc2)n1,,CCO,,O=S(=O)(O)O,,val
US20020132811A1,CC(C)(C)OC(=O)N1CCN2C[C@H](COc3ccc(F)cc3)CC[C@H]2C1>>Fc1ccc(OC[C@@H]2CC[C@H]3CNCCN3C2)cc1,,O,O=C(O)C(F)(F)F,,,val
US20150291563A1,CI.O=C([O-])C(=O)C=Cc1ccc(Br)cc1>>COC(=O)C(=O)C=Cc1ccc(Br)cc1,,CN(C)C=O,,O,,val
US20120202785A1,CC(=O)O.Cc1nc(Cl)ncc1N>>CC(=O)Nc1cnc(Cl)nc1C,,CC(=O)O,,CC(=O)OC(C)=O,,val
US05968938,O=C(O)c1ccccc1OC(F)(F)F>>OCc1ccccc1OC(F)(F)F,,C1CCOC1,,,,val
US07196077B2,C=O.Cc1cc(F)ccc1[C@H]1CCNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl>>Cc1cc(F)ccc1[C@H]1CCN(C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl,[Pd],CO,,,,val
US20140080800A1,CN(C)C(=O)Nc1cc(-c2cccs2)ccc1NC(=O)OC(C)(C)C>>CN(C)C(=O)Nc1cc(-c2cccs2)ccc1N,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050065148A1,Clc1ncc(Br)c(Cl)n1.[OH-]>>O=c1[nH]c(Cl)ncc1Br,,C1CCOC1,,Cl,,val
US20050209241A1,COC(=O)c1cnc(N2CCN(C(=O)OC(C)(C)C)CC2)cn1.N>>CC(C)(C)OC(=O)N1CCN(c2cnc(C(N)=O)cn2)CC1,,CO,,,,val
US20030187254A1,CCN(CC)C(=O)C1=CN(C2CCN(C(=O)OC(C)(C)C)CC2)CCCC1.O=C(Cl)c1c2ccccc2cc2ccccc12>>CCN(CC)C(=O)C1CCCCN(C2CCN(C(=O)c3c4ccccc4cc4ccccc34)CC2)C1,[Pd],CO,ClCCl,CCN(C(C)C)C(C)C,,val
US05700822,N#CCS(=O)(=O)CC#N.O=Cc1cc(O)c(O)c(Br)c1>>N#CCS(=O)(=O)C(C#N)=Cc1cc(O)c(O)c(Br)c1,,CCO,,C1CCNCC1,,val
US20100087433A1,C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.O=C(O)C(c1ccccc1)c1ccccc1.c1ccc(C2CCNCC2)cc1>>O=C(C(c1ccccc1)c1ccccc1)N1CCC(Cn2ccnc2)(c2ccccc2)CC1,,C1CCOC1,,On1nnc2ccccc21,,val
US20100234395A1,COC(=O)C(C(=O)c1ccc(C(C)(C)C)cc1)c1ccc(OC)cc1>>COc1ccc(CC(=O)c2ccc(C(C)(C)C)cc2)cc1,,CS(C)=O,O,[Cl-].[Na+],,val
US04251438,COC(=O)CNC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc(OCc2c(Cl)cccc2Cl)cc1)NC(=O)OC(C)(C)C>>C[C@@H](NC(=O)[C@H](Cc1ccc(OCc2c(Cl)cccc2Cl)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)O,,CC(C)=O,,Cl,[Na+].[OH-],val
US20080227789A1,COc1cc2ncnc(C)c2cc1OC.O=C1CCC(=O)N1Br>>COc1cc2ncnc(CBr)c2cc1OC,,ClC(Cl)(Cl)Cl,ClCCl,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20050010031A1,BrCCBr.COC(=O)C(Cc1ccc2ccccc2c1)NC(=O)C(CC1CC1)NS(=O)(=O)c1ccccc1[N+](=O)[O-]>>COC(=O)C(Cc1ccc2ccccc2c1)N1CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])C(CC2CC2)C1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04282246,Cc1ccc(F)cc1S.O=C(O)c1coc(Br)c1>>Cc1ccc(F)cc1Sc1cc(C(=O)O)co1,,CN(C)C=O,,,,val
US20120088750A1,CCI.CCOC(=O)C1(O)CCN(c2ncc(Br)cn2)CC1>>CCOC(=O)C1(OCC)CCN(c2ncc(Br)cn2)CC1,,CN(C)C=O,,CCCCCC,[H-].[Na+],val
US04215121,CNC.Cc1cc(Cl)nc(N)n1>>Cc1cc(N(C)C)nc(N)n1,,CCO,,,,val
US04333928,CI.COc1ccc2c(c1)CC[C@H]1[C@@H]3CCC(=NN(C)C)[C@@]3(C)CC[C@H]21>>COc1ccc2c(c1)CC[C@H]1[C@@H]3C[C@@H](C)C(=NN(C)C)[C@@]3(C)CC[C@H]21,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20160038504A1,CS(=O)(=O)c1nc(Cl)cc(N2CCOCC2)n1.OC1CNC1>>OC1CN(c2nc(Cl)cc(N3CCOCC3)n2)C1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20160060258A1,CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3ncc4c(=O)n(-c5c(Cl)cccc5Cl)cc(Br)c4n3)cc2)CC1>>O=c1c2cnc(Nc3ccc(N4CCNCC4)cc3)nc2c(Br)cn1-c1c(Cl)cccc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US05521170,Nc1ccc(C(=O)N2CCCc3ccccc32)cc1.O=c1oc(=O)c2ccccc2c2ccccc12>>O=C(O)c1ccccc1-c1ccccc1C(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20040186134A1,CC(=O)CCl.NC(=S)[C@@H]1CCCN1C(=O)OCc1ccccc1>>Cc1csc([C@@H]2CCCN2C(=O)OCc2ccccc2)n1,,ClC(Cl)Cl,,,,val
US20010016579A1,CN1CCCNCC1.Cc1ccc2oc(S)nc2c1>>Cc1ccc2oc(N3CCCN(C)CC3)nc2c1,,ClC(Cl)Cl,,,,val
US20130137680A1,Cn1cc(NC(=O)OC(C)(C)C)nc1C(=O)O.NC1CCCC1>>Cn1cc(NC(=O)OC(C)(C)C)nc1C(=O)NC1CCCC1,,CCOC(C)=O,CN(C)C=O,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US05026856,Fc1ccc2c(c1)CNC2.O=C(O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O>>O=C(O)c1cn(C2CC2)c2c(F)c(N3Cc4ccc(F)cc4C3)c(F)cc2c1=O,,CN(C)C=O,,,,val
US06359143B1,CCOC(=O)C(CCC(=O)C(C(C)=O)c1cc(C)no1)C(C)=O>>CCOC(=O)C1CCC(=O)C(c2cc(C)no2)=C1C,,CO,,CCN(CC)CC,O,val
US20030013707A1,Cc1ccc(N)c(C(=O)O)c1.O=C=Nc1ccc(Oc2ccccc2)cc1>>Cc1ccc2nc(Nc3ccc(Oc4ccccc4)cc3)oc(=O)c2c1,,C1CCOC1,CN(C)C=O,ClCCCl,,val
US20110092499A1,Clc1nc(Cl)c2[nH]ccc2n1>>Clc1ncc2[nH]ccc2n1,[Pd],CCO,,O=C([O-])O.[Na+],,val
US20150210655A1,Nc1cc(Br)cc(Cl)c1O.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]c2cc(Br)cc(Cl)c2o1,,C1CCOC1,,,,val
US20130053412A1,CNc1ccc(C(=O)O)cc1.CNc1ccccc1N>>CNc1ccc(-c2nc3ccccc3n2C)cc1,,O,,[Na+].[OH-],,val
US04877899,C=CC(C)(C)C.OCC(O)CS>>CC(C)(C)CCSCC(O)CO,,CCCCCC,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20160176868A1,CCOC(=O)C[C@@H](Nc1cc(=O)n(CC)c(=O)[nH]1)c1cccc(Cl)c1>>CCn1c(=O)cc(N[C@H](CC(=O)O)c2cccc(Cl)c2)[nH]c1=O,,C1CCOC1,,[Na+].[OH-],,val
US04348519,COC(=O)C1=C(O)c2sc3ccccc3c2S(=O)(=O)N1C.Nc1ccccn1>>CN1C(C(=O)Nc2ccccn2)=C(O)c2sc3ccccc3c2S1(=O)=O,,CO,,Cc1ccccc1C,,val
US20130225577A1,C[Si](C)(C)CCOCn1ccc2c(Cl)ncnc21.O=C(OCc1ccccc1)N1CCCC2NCCC21>>C[Si](C)(C)CCOCn1ccc2c(N3CCC4C3CCCN4C(=O)OCc3ccccc3)ncnc21,,CN(C)C=O,,,,val
US20130330876A1,CCC#Cc1ccc2ccc(OC)cc2c1>>CCCCc1ccc2ccc(OC)cc2c1,[Pd],Cc1ccccc1,,CCCCCC,,val
US20110130398A1,CC(C)(C)CC1NC(C(=O)OC(C)(C)C)C(c2cccc(Br)c2F)C12C(=O)Nc1cc(Cl)ccc12.O=C(O)C(F)(F)F>>CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Br)c2F)C12C(=O)Nc1cc(Cl)ccc12.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20070225324A1,CC(=O)OC[C@@H](C)n1ccc2c([N+](=O)[O-])c(C3CC3)ccc2c1=O>>CC(=O)OC[C@@H](C)n1ccc2c(N)c(C3CC3)ccc2c1=O,[Pd],,,CCO,,val
US20140235702A1,COc1ccccc1I.O=[N+]([O-])O>>COc1ccc([N+](=O)[O-])cc1I,,CC(=O)O,,,,val
US05556977,COC(=O)COc1ccc(C(=O)CN2CCNCC2=O)cc1.Cl.Clc1ccncc1>>Cl.O=C(O)COc1ccc(C(=O)CN2CCN(c3ccncc3)CC2=O)cc1,,C1COCCO1,O,CCN(CC)CC,,val
US20100160441A1,CC1(C(=O)Nc2c(SC(=O)C3(C)CCCCC3)ccc3ccccc23)CCCCC1>>CC1(C(=O)Nc2c(S)ccc3ccccc23)CCCCC1,,C1CCOC1,CO,O,[K+].[OH-],val
US20070293516A1,CC(C)n1nc(I)c2c(N)ncnc21.N#Cc1ccc(B(O)O)cn1>>CC(C)n1nc(-c2ccc(C#N)nc2)c2c(N)ncnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20150376225A1,CC1([C@H]2CCC3C4CC=C5C[C@@H](O)CC[C@]5(C)C4[C@@H](O)C[C@@]32C)OCCO1.CI>>CO[C@H]1CC[C@@]2(C)C(=CCC3C4CC[C@H](C5(C)OCCO5)[C@@]4(C)C[C@H](O)C32)C1,,C1CCOC1,,[H-].[Na+],,val
US05922725,CC(C)Br.CCON=C(C)c1ccc2c(c1)ncn2-c1cccc(-c2cccnc2)c1>>CC(=NOC(C)C)c1ccc2c(c1)ncn2-c1cccc(-c2cccnc2)c1,,CN(C)C=O,O,[H-].[Na+],,val
US20080242685A1,CCS(=O)(=O)Cl.NC(=O)c1nc(-c2ccccc2)cc2c(C3CCNCC3)n[nH]c12>>CCS(=O)(=O)N1CCC(c2n[nH]c3c(C(N)=O)nc(-c4ccccc4)cc23)CC1,CN(C)c1ccncc1,CN(C)C=O,,CCN(CC)CC,,val
US05470878,Br.CC(=O)O.Cc1cn(C)c(=O)n(CCCCC(O)CO)c1=O>>CC(=O)OC(CBr)CCCCn1c(=O)c(C)cn(C)c1=O,,ClCCl,O,O=C([O-])O.[Na+],,val
US20060128712A1,C1CNCCN1.COc1ccc2nc(Cl)sc2c1>>COc1ccc2nc(N3CCNCC3)sc2c1,,C1CCOC1,,CCN(CC)CC,,val
US20070155726A1,COC(=O)c1ccc(CN(CCOc2ccc(Cc3ccc(-c4ncco4)cc3)cc2)CCN2CCOCC2)cc1>>O=C(O)c1ccc(CN(CCOc2ccc(Cc3ccc(-c4ncco4)cc3)cc2)CCN2CCOCC2)cc1,,CO,,[Na+].[OH-],,val
US20100310512A1,COC(=O)c1ccc(-c2ccc(C(=O)OC)cc2I)c(I)c1>>O=C(O)c1ccc(-c2ccc(C(=O)O)cc2I)c(I)c1,,C1CCOC1,,O,[K+].[OH-],val
US20130012499A1,CCOc1cc2nc(-c3cccc(C(F)(F)F)c3)c(C)c(C(=O)OC)c2cc1S(C)(=O)=O.O=C1CCC(=O)N1Br>>CCOc1cc2nc(-c3cccc(C(F)(F)F)c3)c(CBr)c(C(=O)OC)c2cc1S(C)(=O)=O,,ClC(Cl)(Cl)Cl,,,,val
US20120259123A1,CCCCC1(c2ccc(CC(NS(=O)(=O)c3ccncc3)c3cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n3)cc2)CC1>>CCCCC1(c2ccc(CC(NS(=O)(=O)c3ccncc3)c3cccc(NCC(=O)O)n3)cc2)CC1,,O,,C1CCOC1,Cl,val
US20120264737A1,CC(=O)OC(C)=O.Cc1cc(C)c(-c2nc3c([nH]2)CNCC3)cc1C(=O)N1CCC(c2ccc(C#N)cc2)CC1>>CC(=O)N1CCc2nc(-c3cc(C(=O)N4CCC(c5ccc(C#N)cc5)CC4)c(C)cc3C)[nH]c2C1,,CCOC(C)=O,CN(C)C=O,,,val
US20070032502A1,CC[C@@H](C)[C@H](Nc1nc(CCl)nc2ccccc12)C(N)=O.c1ccc(N2CCNCC2)cc1>>CC[C@@H](C)[C@H](Nc1nc(CN2CCN(c3ccccc3)CC2)nc2ccccc12)C(N)=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100190745A1,CC(C)C[C@H](N)CO.CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2ccc(F)c(C(=O)C(=CN(C)C)C(=O)OCC)c2)cn1>>CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2ccc3c(c2)c(=O)c(C(=O)OCC)cn3[C@H](CO)CC(C)C)cn1,,C1CCOC1,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090291079A1,CC(C)Oc1nc(-c2ccc(N)cc2)nc(N2CCOCC2)n1.COC(=O)c1ccc(N=C=O)cc1>>COC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(OC(C)C)nc(N4CCOCC4)n3)cc2)cc1,,CCN(CC)CC,,,,val
US20080275097A1,Cc1ccnc(CNC(=O)Cc2n[nH]c3ncccc23)c1Oc1cc(Cl)cc(Br)c1>>Cc1ccn2c(Cc3n[nH]c4ncccc34)ncc2c1Oc1cc(Cl)cc(Br)c1,,Cc1ccccc1,,O=P(Cl)(Cl)Cl,,val
US20020028832A1,CC(C)(C)[Si](Oc1ccc(OCC2CO2)cc1)(c1ccccc1)c1ccccc1.CCCCCCNC(=O)Nc1ccc(CNC(=O)N2CCC(Nc3ccc(CCN)cc3)CC2)cc1>>CCCCCCNC(=O)Nc1ccc(CNC(=O)N2CCC(Nc3ccc(CCNC[C@H](O)COc4ccc(O)cc4)cc3)CC2)cc1,,CO,ClC(Cl)Cl,O=CO,,val
US20110201593A1,CC(CC#N)N1CCC(N)CC1.O=[N+]([O-])c1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1Cl>>CC(CC#N)N1CCC(Nc2c([N+](=O)[O-])cnc3c2ccn3S(=O)(=O)c2ccccc2)CC1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20030092677A1,CC(C)(C)OC(=O)Nc1ccc(-c2ccc(OC(F)(F)F)cc2)cc1[N+](=O)[O-]>>CC(C)(C)OC(=O)Nc1ccc(-c2ccc(OC(F)(F)F)cc2)cc1N,[Ni],,,,,val
US20100239526A1,COc1ccc(Cn2ncc3c4c(cnc32)CC(NC(=O)Nc2ccccc2)CC4)cc1>>O=C(Nc1ccccc1)NC1CCc2c(cnc3[nH]ncc23)C1,,Cc1ccccc1,,O=C(O)C(F)(F)F,,val
US20010021718A1,CN(C)C(=O)c1coc([C@H](CCCC2CCC2)CC(=O)O)n1.C[Si](C)(C)ON>>CN(C)C(=O)c1coc([C@H](CCCC2CCC2)CC(=O)NO)n1,,C1CCOC1,CO,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20160137653A1,CC(C)(C)OC(=O)N1CCC(O)(CN)CC1.O=C(O)c1ccc(Cl)cc1>>CC(C)(C)OC(=O)N1CCC(O)(CNC(=O)c2ccc(Cl)cc2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US05310951,CCCc1c(OCCCI)ccc2c1OC(CCC(=O)OC)CC2.NC(=O)c1ccc(O)c(CC2CC2)c1O>>CCCc1c(OCCCOc2ccc(C(N)=O)c(O)c2CC2CC2)ccc2c1OC(CCC(=O)OC)CC2,,CCCCCC,CCOC(C)=O,,,val
US20100022537A1,COC(=O)CC(C)=O.N#Cc1ccc(C=O)cc1.NC(=S)Nc1cccc(C(F)(F)F)c1>>COC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=S)NC1c1ccc(C#N)cc1,,C1CCOC1,,,,val
US20120172411A1,CCCCC/C=C\C/C=C\CCCCCCCCC(O)(CCCCCCC/C=C\C/C=C\CCCCC)C(O)CCCCCCC/C=C\C/C=C\CCCCC.O=C(Cl)OC(Cl)(Cl)Cl>>CCCCC/C=C\C/C=C\CCCCCCCCC1(CCCCCCC/C=C\C/C=C\CCCCC)OC(=O)OC1CCCCCCC/C=C\C/C=C\CCCCC,,CCOCC,,c1ccncc1,,val
US20060019997A1,COC(=O)CCl.Cn1c(-c2cccnc2)n[nH]c1=S>>COC(=O)CSc1nnc(-c2cccnc2)n1C,CN(C)C=O,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040171620A1,CN(C)c1ccncc1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=c1cccc[nH]1>>COc1ccc2nccc(OS(=O)(=O)C(F)(F)F)c2n1,CN(C)c1ccncc1,,,Cc1cccc(C)n1,,val
US20100197634A1,COc1nccc2c(Nc3c(Cl)cc(C4(C)OCCO4)cc3Cl)nc3ccc(Br)cc3c12>>CC(=O)c1cc(Cl)c(Nc2nc3ccc(Br)cc3c3c(=O)[nH]ccc23)c(Cl)c1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20080090854A1,CC(C)(C)OC(=O)C(C)(C)NC(=O)c1cc(Cl)c2ccccc2c1OCc1cnc(C(F)(F)F)nc1>>CC(C)(NC(=O)c1cc(Cl)c2ccccc2c1OCc1cnc(C(F)(F)F)nc1)C(=O)O,,O,,O=C(O)C(F)(F)F,,val
US05840917,CCc1ccsc1C(=O)OC>>CCc1ccsc1C(=O)O,,CO,,C1CCOC1,[Na+].[OH-],val
US20150329542A1,CN.COc1ccc(C#N)c(F)c1>>CNc1cc(OC)ccc1C#N,,CC#N,,,,val
US20150368267A1,CC(C)(C)OC(=O)N1CCC2(CCN(C(=O)c3ccc(Nc4nc(NCc5ccc(OCCCBr)cc5)nc(OCC(F)(F)F)n4)cc3)C2)C1>>O=C(c1ccc(Nc2nc(NCc3ccc(OCCCBr)cc3)nc(OCC(F)(F)F)n2)cc1)N1CCC2(CCNC2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05932745,COC(=O)c1ccc(C(=O)C=CN(C)C)cc1Cl.NN>>COC(=O)c1ccc(-c2cc[nH]n2)cc1Cl,,CCO,,Cl,,val
US20150141474A1,O=C(CO)CCC(=O)c1ccc(Br)cc1>>OC1CCC(c2ccc(Br)cc2)OC1,,ClCCl,,CC[SiH](CC)CC,,val
US20090005370A1,CC(=O)c1ccc(-n2cnc(-c3c(-c4ccc(F)cc4)noc3C(F)(F)F)c2)cc1.C[Mg]Br>>CC(C)(O)c1ccc(-n2cnc(-c3c(-c4ccc(F)cc4)noc3C(F)(F)F)c2)cc1,,C1CCOC1,Cl,,,val
US20110306602A1,CS(=O)(=O)c1cccc(N)c1.Clc1cc(-c2ccccc2OCc2ccccc2)ncn1>>CS(=O)(=O)c1cccc(Nc2cc(-c3ccccc3OCc3ccccc3)ncn2)c1,,CN(C)C=O,O,Cl,O=C([O-])O.[Na+],val
US20120082702A1,CCOC(=O)c1cnc(Cl)cc1Nc1ccc(C(=O)N2CCOCC2)cc1>>O=C(O)c1cnc(Cl)cc1Nc1ccc(C(=O)N2CCOCC2)cc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20150344437A1,Cn1[nH]c(-c2ccccc2Cl)c(C=O)c1=O>>Cc1c(-c2ccccc2Cl)nn(C)c1O,,CC(=O)O,,,,val
US06689806B1,O=C1Cc2c(CCO)cccc2N1.O=Cc1ccc2[nH]ccc2c1>>O=C1Nc2cccc(CCO)c2C1=Cc1ccc2[nH]ccc2c1,C1CCNCC1,CCO,,,,val
US20030013720A1,CC(C)(C)OC(=O)N1CCC(CN)(c2ccc(I)cc2)CC1.O=C(Cl)Cc1cc(F)cc(F)c1>>CC(C)(C)OC(=O)N1CCC(CNC(=O)Cc2cc(F)cc(F)c2)(c2ccc(I)cc2)CC1,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US06982260B1,COC1=C(C2CCCC2)C(=O)C(C=O)CC1.N=C(N)N>>C1=NCNc2ccccc21,,CN(C)C=O,,O=C(O)O,,val
US20120058988A1,COC(=O)c1cc(I)cc(Br)c1N.OB(O)c1cccc(C(F)(F)F)c1>>COC(=O)c1cc(-c2cccc(C(F)(F)F)c2)cc(Br)c1N,,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20070276140A1,C[Sn](C)(C)Cl.Cc1cccc2c(Br)c3ccccc3nc12>>Cc1cccc2c([Sn](C)(C)C)c3ccccc3nc12,,CCOCC,,[Li]CCCC,,val
US20150031727A1,CC(=O)c1ccc([N+](=O)[O-])cc1.COC(=O)c1ccc(C=O)cc1>>COC(=O)c1ccc(C=CC(=O)c2ccc([N+](=O)[O-])cc2)cc1,,CCO,,C1CCNCC1,,val
US20040077896A1,O=C(CBr)c1ccc(OCc2c(F)cccc2F)cc1.Sc1nc[nH]n1>>O=C(CSc1nc[nH]n1)c1ccc(OCc2c(F)cccc2F)cc1,,ClCCl,,CCN(CC)CC,,val
US20160009720A1,CS(=O)(=O)Cl.Cc1ccc(-c2c(-c3ccc(C#N)cc3)nc(CO)c3nccn23)cc1>>Cc1ccc(-c2c(-c3ccc(C#N)cc3)nc(COS(C)(=O)=O)c3nccn23)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080139561A1,C[C@H](Nc1nc(Nc2cc(C3CC3)[nH]n2)c(F)cc1CN)c1ccc(F)cc1.O=C(O)CN1CCOCC1>>C[C@H](Nc1nc(Nc2cc(C3CC3)[nH]n2)c(F)cc1CNC(=O)CN1CCOCC1)c1ccc(F)cc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150336925A1,Cc1cc(OCCCc2c(C(=O)NS(=O)(=O)C3CCNCC3)[nH]c3cc(Cl)ccc23)cc(C)c1Cl.O=C(O)CCc1ccccc1>>Cc1cc(OCCCc2c(C(=O)NS(=O)(=O)C3CCN(C(=O)CCc4ccccc4)CC3)[nH]c3cc(Cl)ccc23)cc(C)c1Cl,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US06350749B1,Cl.N=C(N)NN.O=C1CC(c2ccccc2)Cc2c1ccn2Cc1ccccc1>>Cl.N=C(N)NN=C1CC(c2ccccc2)Cc2c1ccn2Cc1ccccc1,,CCO,,Cl,O,val
US20060135488A1,COC(=O)CBr.N#Cc1sc2c(sc3cc(Cl)ccc32)c1O>>COC(=O)COc1c(C#N)sc2c1sc1cc(Cl)ccc12,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20080146612A1,CCOC(=O)c1ccccc1-c1ccc(Cl)c(C(=O)NCC2(O)CCCCCC2)c1>>O=C(NCC1(O)CCCCCC1)c1cc(-c2ccccc2C(=O)O)ccc1Cl,,O,,CO,[K+].[OH-],val
US20120232083A1,COc1cccc(-c2cc(=O)n(CC[C@](C)(C(=O)NOC3CCCCO3)S(C)(=O)=O)cc2F)c1F>>COc1cccc(-c2cc(=O)n(CC[C@](C)(C(=O)NO)S(C)(=O)=O)cc2F)c1F,,CCO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US06589977B1,CN(C)CCCCl.CN1C(=O)C(c2c[nH]c3ccccc23)=C(c2c[nH]c3ccccc23)C1=O>>CN(C)CCCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)N(C)C2=O)c2ccccc21,,CN(C)C=O,,Cl,[H-].[Na+],val
US20030166668A1,C=CCc1cc(CC(=O)OC)cnc1CC.O=[O+][O-]>>CCc1ncc(CC(=O)OC)cc1CC=O,,CO,ClCCl,CSC,,val
US06093714,C#CC(=O)OCC.CC(C)(C)OC(=O)Nc1ccc(C=O)c([N+](=O)[O-])c1>>CCOC(=O)C#CC(O)c1ccc(NC(=O)OC(C)(C)C)cc1[N+](=O)[O-],,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20130131039A1,N#CCC1(n2cc(-c3nc(Cl)cc4nccn34)cn2)CNC1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>N#CCC1(n2cc(-c3nc(Cl)cc4nccn34)cn2)CN(CC(F)(F)F)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US04631277,CBr.c1ccc2c(c1)OC1CCCC(OCCN3CCOCC3)C1O2>>C[N+]1(CCOC2CCCC3Oc4ccccc4OC23)CCOCC1.[Br-],,CC(C)=O,,,,val
US20050020684A1,C=CCc1cc(C[C@H](OC)C(=O)OCC)ccc1OCCCOc1ccc(Oc2ccccc2)cc1>>CCCc1cc(C[C@H](OC)C(=O)O)ccc1OCCCOc1ccc(Oc2ccccc2)cc1,,CCO,,,,val
US20100056490A1,CCc1cc(C[C@@H]2CS(=O)(=O)C[C@H]3[C@H]2OC(=O)N3Cc2cccc(C(C)(C)C)c2)cc(F)c1N.O=C(Cl)CCl>>CCc1cc(C[C@@H]2CS(=O)(=O)C[C@H]3[C@H]2OC(=O)N3Cc2cccc(C(C)(C)C)c2)cc(F)c1NC(=O)CCl,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20100267723A1,C1COCCN1.O=Cc1ccc(Cl)c(F)c1>>Fc1cc(CN2CCOCC2)ccc1Cl,,CC(Cl)Cl,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20070129334A1,COc1cc(Br)c(OC)c([N+](=O)[O-])c1.OB(O)c1ccccc1>>COc1cc(-c2ccccc2)c(OC)c([N+](=O)[O-])c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US05292726,CCCCCN(CCCCC)C(=O)Cl.O=C(O)C1CNCCN1C(=O)C(c1ccccc1)c1ccccc1>>CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1,,C1CCOC1,,CCN(CC)CC,,val
US06960575B2,COC(=O)[C@H](Cc1ccccc1)NC(=O)CN1C(=O)C(C(C)C)N(C(C)=O)C=C1c1ccccc1>>CC(=O)N1C=C(c2ccccc2)N(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C(=O)C1C(C)C,,CCO,,[Na+].[OH-],,val
US20090181965A1,Cc1c[nH]cn1.Cc1cc([N+](=O)[O-])ccc1Cl>>Cc1cn(-c2ccc([N+](=O)[O-])cc2C)cn1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070032515A1,COCCOc1c(OC(=O)c2ccccc2)cc([N+](=O)[O-])cc1C(=O)OC>>COCCOc1c(O)cc([N+](=O)[O-])cc1C(=O)OC,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150126449A1,N#Cc1c(F)ccc(F)c1Br.NN>>Nc1n[nH]c2ccc(F)c(Br)c12,,CCO,,O,,val
US20140114068A1,COc1sccc1C(=O)NC12C(=O)c3c([N+](=O)[O-])cccc3C1(O)Oc1cc(C(C)C)ccc12>>COc1sccc1C(=O)NC12C(=O)c3c(N)cccc3C1(O)Oc1cc(C(C)C)ccc12,[Fe],,,Cl,,val
US20090325953A1,FC(F)(F)c1ccn2cc(CCl)nc2c1.NCC1OCCO1>>FC(F)(F)c1ccn2cc(CNCC3OCCO3)nc2c1,,ClCCl,,,,val
US20140094459A1,CC(C)(C)OC(=O)N1CCC[C@H]1CO.Clc1ncnc2[nH]cc(I)c12>>CC(C)(C)OC(=O)N1CCC[C@H]1Cn1cc(I)c2c(Cl)ncnc21,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070191293A1,Clc1nc[nH]c2nccc1-2.Sc1ccccc1>>c1ccc(Sc2ncnc3[nH]ccc23)cc1,,CCCCO,,,,val
US20040147487A1,CC(C)=O.COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO>>CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O,,CC(C)=O,,,,val
US20110306607A1,BrCc1ccccc1.COc1cc(C(=O)O)ccc1Br>>COc1cc(C(=O)OCc2ccccc2)ccc1Br,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04496542,CCOC(=O)CNc1cccnc1.CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)O>>CCOC(=O)CN(C(=O)[C@@H](NC(=O)OCc1ccccc1)[C@@H](C)CC)c1cccnc1,,ClCCl,,,,val
US20110034440A1,CCOC(=O)CBr.CCOC(C)=O.Cc1cc(C(=O)OC(C)(C)C)ccc1N>>CCOC(=O)CN(CC(=O)OCC)c1ccc(C(=O)OC(C)(C)C)cc1C,,CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US20100056511A1,O=S(=O)(Cl)c1cccnc1.O=[N+]([O-])c1ccc(N2CCNCC2)cc1>>O=[N+]([O-])c1ccc(N2CCN(S(=O)(=O)c3cccnc3)CC2)cc1,,C1CCOC1,c1ccncc1,,,val
US20100022580A1,CN1CCC(=O)CC1.Cc1ccc(NN)cc1.O=C(NCCBr)OCC(Cl)(Cl)Cl>>Cc1ccc2c(c1)c1c(n2CCNC(=O)OCC(Cl)(Cl)Cl)CCN(C)C1,,CCO,Cl,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20040260088A1,CI.N#Cc1ccc(Cl)cc1Oc1cc(O)cc(C=O)c1>>COc1cc(C=O)cc(Oc2cc(Cl)ccc2C#N)c1,,CN(C)C=O,O,[H-].[Na+],,val
US07071201B2,COc1ccc2c(c1)N(C1CCN(CCc3ccc(F)cc3)CC1)CC2.O=C1CCC(=O)N1Cl>>COc1cc2c(cc1Cl)CCN2C1CCN(CCc2ccc(F)cc2)CC1,,ClCCl,,CCOC(C)=O,[Na+].[OH-],val
US20160264554A1,CC(C)(C)OC(=O)N(Cc1ccc(N)cc1)[C@H]1CCC[C@@H](Nc2ncc(Cl)c(-c3cn(S(=O)(=O)c4ccccc4)c4ccccc34)n2)C1>>CC(C)(C)OC(=O)N(Cc1ccc(N)cc1)[C@H]1CCC[C@@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1,,C1COCCO1,,O,[Na+].[OH-],val
US20100298302A1,CCOC(=O)c1cccc2c1nc(Cl)c1nccn12.Nc1ccccc1F>>CCOC(=O)c1cccc2c1nc(Nc1ccccc1F)c1nccn12,,CN(C)C=O,O,,,val
US20160264518A1,CON(C)C(=O)c1ccc(-c2ccccc2)c(C(F)(F)F)c1>>O=Cc1ccc(-c2ccccc2)c(C(F)(F)F)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04025537,CCC=C(C(C)=O)C(=O)OCC.O=C1CCC(=O)N1Br>>CCOC(=O)C(=CC(C)Br)C(C)=O,,ClC(Cl)(Cl)Cl,,,,val
US08420830B2,C[Si](C)(C)C=[N+]=[N-].Cc1cc(B(O)O)ccc1[C@@H](C)CO[Si](C)(C)C(C)(C)C.Nc1ccc2cc[nH]c(=O)c2c1.O=CC(=O)O>>COC(=O)C(Nc1ccc2cc[nH]c(=O)c2c1)c1ccc([C@@H](C)CO)c(C)c1,,CC#N,CN(C)C=O,O,,val
US20160185778A1,CC1(C(=O)O)CCC1.O=C(n1ccnc1)n1ccnc1>>CC1(C(=O)n2ccnc2)CCC1,,ClCCl,,,,val
US20090093454A1,CN1CCN(c2cccc3c2nc(CN2CCC[C@@H]4CCc5cccnc5[C@@H]42)n3C(=O)OC(C)(C)C)CC1>>CN1CCN(c2cccc3[nH]c(CN4CCC[C@@H]5CCc6cccnc6[C@@H]54)nc23)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160038504A1,CSc1cccc(C(=O)O)c1.O>>CS(=O)c1cccc(C(=O)O)c1,,CO,,,,val
US20070265265A1,O=C(Cl)OCc1ccccc1.O=C(NC1CC1)c1ccc(-c2csc(NC(=O)[C@H]3NCCS3)n2)cc1>>O=C(NC1CC1)c1ccc(-c2csc(NC(=O)[C@@H]3SCCN3C(=O)OCc3ccccc3)n2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130096113A1,CSc1nc2ccc(C=O)cc2s1.Nc1ccc(OCc2ccccc2)cc1[N+](=O)[O-]>>CSc1nc2ccc(CNc3ccc(OCc4ccccc4)cc3[N+](=O)[O-])cc2s1,,ClCCl,O=C(O)C(F)(F)F,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20060030590A1,CCCCc1nc2ccccc2n1C1CCNCC1.Fc1ccc(SCCCBr)cc1>>CCCCc1nc2ccccc2n1C1CCN(CCCSc2ccc(F)cc2)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100197633A1,CC=CC(C)=O.C[Si](C)(C)C[Mg]Cl>>CC(=O)CC(C)C[Si](C)(C)C,,CCOCC,,,,val
US20110105509A1,COC(=O)Cn1nc(-c2c(C)n(CC(=O)O)c3ccc(F)cc23)c2ccccc2c1=O.NN>>Cc1c(-c2nn(CC(=O)NN)c(=O)c3ccccc23)c2cc(F)ccc2n1CC(=O)O,,CO,,,,val
US20150038488A1,Brc1cnc(N2CCOCC2)s1.C[C@@H](Oc1nc(B2OC(C)(C)C(C)(C)O2)cc2ncn(C3CC3)c12)[C@H]1CNC(=O)C1>>C[C@@H](Oc1nc(-c2cnc(N3CCOCC3)s2)cc2ncn(C3CC3)c12)[C@H]1CNC(=O)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,ClCCl,N#N,O=C([O-])[O-].[Na+].[Na+],val
US05698579,O=C(O)CC(c1ccccc1)N1Cc2ccccc2C1=O.O=C(n1ccnc1)n1ccnc1>>NC(=O)CC(c1ccccc1)N1Cc2ccccc2C1=O,,C1CCOC1,,,,val
US20040122057A1,CCOC(C(=O)NCc1ccc(C#N)cc1O)c1c(F)cc(OC)cc1F.CCOC(C(=O)NCc1ccc(C#N)cc1OCC#N)c1c(F)cc(OC)cc1F.CCOC(C(=O)NCc1ccc(C#N)cc1OCc1ncon1)c1c(F)cc(OC)cc1F.ClCc1ncon1>>CCOC(C(=O)NCc1ccc(C(=N)N)cc1OCC(=O)NCCN(CC)CC)c1c(F)cc(OC)cc1F.Cl,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040204386A1,CCOc1ccc(Cl)cc1-c1cc(Cl)nc(N)n1.Cc1ccc(N)cc1>>CCOc1ccc(Cl)cc1-c1cc(Nc2ccc(C)cc2)nc(N)n1,,C1COCCO1,CCO,Cl,,val
US20050267180A1,CCO[C@@H](Cc1ccc(OCc2ccccc2)cc1C)C(=O)OC>>CCO[C@@H](Cc1ccc(O)cc1C)C(=O)OC,[Pd],CO,,,,val
US20120065196A1,COC(=O)[C@@H]1CC[C@@H](C(=O)NNC(=O)OC(C)(C)C)CC1.Cl>>COC(=O)[C@@H]1CC[C@@H](C(=O)NN)CC1.Cl,,CCOCC,ClCCl,O=C(O)C(F)(F)F,,val
US05753634,CCOP(=O)(OCC)C1(P(=O)(OCC)OCC)C=C2C=C(Br)CNC2=C1>>CCOP(=O)(OCC)C1(P(=O)(OCC)OCC)C=c2cccnc2=C1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20120015052A1,Cc1noc([C@@H](C)NC(=O)c2cc3c(-c4ccc(F)cc4F)n[nH]c3s2)n1.OCCI>>Cc1noc([C@@H](C)NC(=O)c2cc3c(-c4ccc(F)cc4F)nn(CCO)c3s2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04786672,Nc1ccccc1Cl.OCCNc1nc(Cl)nc(NCCO)n1>>OCCNc1nc(NCCO)nc(Nc2ccccc2Cl)n1,,O,,[Na+].[OH-],,val
US20110178089A1,CN(C)c1ccc(Cl)cc1N.O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21>>CN(C)c1ccc(Cl)cc1NC(=O)c1cnccc1Oc1cc(Cl)ccc1Cl,,CCCCCCC,CCOC(C)=O,Cl,Cl,val
US05395969,CCI.c1ccc(Nc2cccc3ccccc23)cc1>>CCN(c1ccccc1)c1cccc2ccccc12,[Cu],CN1CCCC1=O,,O,[K+].[OH-],val
US20140194431A1,CC(c1ccccc1)N(CCO)C(=O)c1nc(CC2(c3ccc(Cl)cc3)CCCC2)nc(O)c1OCc1ccccc1>>CC(c1ccccc1)N1CCn2c(CC3(c4ccc(Cl)cc4)CCCC3)nc(=O)c(OCc3ccccc3)c2C1=O,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040229949A1,CC(C)S(=O)(=O)Cl.CCOC(=O)C(Cc1ccc(OCCc2ccc(O)cc2)cc1)OCC>>CCOC(=O)C(Cc1ccc(OCCc2ccc(OS(=O)(=O)C(C)C)cc2)cc1)OCC,,ClCCl,,CCN(CC)CC,O,val
US20160039797A1,NCCC1CNCCO1.Nc1cc(Br)cc(C(=O)O)c1>>Nc1cc(Br)cc(C(=O)NCCN2CCOCC2)c1,,ClCCl,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US20140323468A1,CC(=O)O.N#Cc1c(-c2cnc3c(c2)CCCN3C(N)=O)cncc1C1CCNCC1>>CC(=O)N1CCC(c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2C#N)CC1,,CC#N,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120122843A1,C=O.CC1NCC(C2CC2)Oc2nc(Cl)ccc21>>CC1c2ccc(Cl)nc2OC(C2CC2)CN1C,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080255086A1,CNC(=O)c1c(NC(=O)CBr)sc2c1CCCC2.O=Cc1c[nH]nc1C(F)(F)F>>CNC(=O)c1c(NC(=O)Cn2cc(C=O)c(C(F)(F)F)n2)sc2c1CCCC2,,C1CCOC1,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20140187538A1,CC(C(=O)O)c1cccc(Cl)c1.CCN>>CC(C(N)=O)c1cccc(Cl)c1,,C1CCOC1,,CS(=O)(=O)Cl,,val
US20030114443A1,COC(=O)c1ccc(NC2CCN(CCCN(C(=O)C3CCN(C(C)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1>>CC(=O)N1CCC(C(=O)N(CCCN2CCC(Nc3ccc(C(=O)O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1,,CCO,,Cl,[Na+].[OH-],val
US07060822B1,Cc1cc(C)c(C=O)[nH]1.O=C(Cl)CCl>>Cc1[nH]c(C=O)c(C)c1C(=O)CCl,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20140294898A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(O)/C=C/c1c[nH]c2ccccc12>>CC(C)(C)OC(=O)n1cc(/C=C/C(=O)O)c2ccccc21,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,,val
US06232318B1,Cc1cn(Cc2ccccc2)c(=O)n(CCCNC(=O)OC(C)(C)C)c1=O>>Cc1cn(Cc2ccccc2)c(=O)n(CCCN)c1=O,,CCOC(C)=O,,Cl,,val
US20140275049A1,COC(=O)c1ccc(-c2cc(-c3cc(OC(C)C)cc(C(C)(C)C)c3)n(-c3ccc(C(N)=O)cc3)n2)cc1>>CC(C)Oc1cc(-c2cc(-c3ccc(C(=O)O)cc3)nn2-c2ccc(C(N)=O)cc2)cc(C(C)(C)C)c1,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US20070249620A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ncccc1C(F)(F)F>>CC(C)(C)OC(=O)Nc1ncccc1C(F)(F)F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20060128712A1,CCS(=O)(=O)c1ccc(O)c(N)c1.S=C=S>>CCS(=O)(=O)c1ccc2oc(S)nc2c1,,CCO,,[K+].[OH-],,val
US20110178117A1,CCN(CC)S(F)(F)F.OCCCCCCC1Cn2c(nc3ccccc32)O1>>FCCCCCCC1Cn2c(nc3ccccc32)O1,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US20120309745A1,CN(C)C(=O)C(=O)O.NC12CCC(CC1)Cn1c2nc(-c2nc(Cc3ccc(F)cc3)c[nH]2)c(O)c1=O>>CN(C)C(=O)C(=O)NC12CCC(CC1)Cn1c2nc(-c2nc(Cc3ccc(F)cc3)c[nH]2)c(O)c1=O,CN(C)c1ccncc1,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030191323A1,FC(F)(F)c1ccc(CCl)cc1.NS(=O)(=O)c1ccccc1NC(=O)c1cccc(OCc2ccccc2)c1.O>>O=C(Nc1ccccc1S(=O)(=O)NC(=O)c1ccc(C(F)(F)F)cc1)c1cccc(OCc2ccccc2)c1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20050124622A1,COC(=O)c1c(C(=O)O)nc2cc(Cl)ccc2c1O.O=S(Cl)Cl>>COC(=O)c1c(C(=O)Cl)[nH]c2cc(Cl)ccc2c1=O,,ClC(Cl)Cl,,,,val
US20150175594A1,COCCc1noc(-c2c(NC(=O)C3=C(C(=O)O)CCCC3)sc3c2CCOC3)n1.O=C1OC(=O)C2=C1C1CCC2CC1>>COCCc1noc(-c2c(NC(=O)C3=C(C(=O)O)C4CCC3CC4)sc3c2CCOC3)n1,,CCOCC,ClCCl,,,val
US20150353499A1,CC[C@@H](C(=O)N[C@H]1CCc2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O)N(C)C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CC[C@H](NC)C(=O)N[C@H]1CCc2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US09056832B2,N#Cc1cc(F)ccc1C(F)(F)F>>N#Cc1ccc(F)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04061656,Cc1ccsc1CO.[Br-].c1ccc([PH+](c2ccccc2)c2ccccc2)cc1>>Cc1ccsc1C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-],,CC#N,,,,val
US20130236434A1,CC(C)(C)OC(=O)NCc1cccc(NS(C)(=O)=O)c1.Cl>>CS(=O)(=O)Nc1cccc(CN)c1.Cl,,C1COCCO1,,,,val
US20090069287A1,CC(C)c1cccc(Br)c1.O=C1CCN(C(=O)OCc2ccccc2)CC1>>CC(C)c1cccc(C2(O)CCN(C(=O)OCc3ccccc3)CC2)c1,,C1CCOC1,,II,,val
US06114390,CCN(CC)CCCCl.O=C(Cc1c[nH]c2ccccc12)OCc1ccccc1>>CCN(CC)CCCn1cc(CC(=O)OCc2ccccc2)c2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080103123A1,CC(C)(C)OC(=O)N1CCN(C(=O)Cc2ccc(Cl)nc2)CC1.CS(=O)(=O)c1ccc(B(O)O)cc1>>CC(C)(C)OC(=O)N1CCN(C(=O)Cc2ccc(-c3ccc(S(C)(=O)=O)cc3)nc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20080015157A1,CCCCCN1C=Nc2cccc3nc4c(c1c23)Cn1c-4cc2c(c1=O)COC(=O)[C@]2(O)CC.CN(CC(=O)O)C(=O)CNC(=O)OC(C)(C)C>>CCCCCN1C=Nc2cccc3nc4c(c1c23)Cn1c-4cc2c(c1=O)COC(=O)[C@@]2(CC)OC(=O)CN(C)C(=O)CNC(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20140275548A1,CC(C)(C)OC(=O)N1C(=O)CCc2ccc(OCc3cccc(Cl)c3)cc21.CCOC(=O)CBr>>CCOC(=O)CC1Cc2ccc(OCc3cccc(Cl)c3)cc2N(C(=O)OC(C)(C)C)C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120309735A1,CC(=O)Cl.CC(C)(C)OC(=O)N(c1cc(N)cc(-c2cnc(N3CCCNC(=O)C3)s2)c1)c1nccc(C(F)(F)F)n1>>CC(=O)Nc1cc(-c2cnc(N3CCCNC(=O)C3)s2)cc(N(C(=O)OC(C)(C)C)c2nccc(C(F)(F)F)n2)c1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20120202996A1,CC(=O)N1c2ccc(NC(=O)OC(C)(C)C)cc2C(C)=CC1(C)C.Clc1ccccc1>>CC(=O)N1c2ccc(N)cc2C(C)(c2ccc(Cl)cc2)CC1(C)C,,Clc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100029745A1,O=C(C=Cc1ccc(O)c(Cl)c1Cl)c1ccc(-c2ccc(Br)cc2)s1>>O=C(CCc1ccc(O)c(Cl)c1Cl)c1ccc(-c2ccc(Br)cc2)s1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20120277224A1,CCOC(=O)CC(=O)c1ccc2c(c1)c(C)nn2C(C)=O.Nc1n[nH]c(N)c1-c1ccccn1>>CC(=O)n1nc(C)c2cc(-c3cc(=O)n4nc(N)c(-c5ccccn5)c4[nH]3)ccc21,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04186132,CC1C(=S)Nc2ccc(Cl)cc21.O=C1CCC(=O)N1Cl>>CC1(Cl)C(=S)Nc2ccc(Cl)cc21,,ClC(Cl)(Cl)Cl,,,,val
US04686219,CCOC(=O)c1nccn1Cc1ccccc1[N+](=O)[O-]>>CCOC(=O)c1nccn1Cc1ccccc1N,[Ni],C1CCOC1,,,,val
US07015218B1,COC(=O)c1cc(-c2ccccc2)nn1C>>Cn1nc(-c2ccccc2)cc1C(=O)O,,CCO,O,[Na+].[OH-],,val
US20130035326A1,Nc1ccc(-c2cnc(NC3CC3)nc2)cn1.O=C(Cl)Cc1cccc(C(F)(F)F)c1>>O=C(Cc1cccc(C(F)(F)F)c1)Nc1ccc(-c2cnc(NC3CC3)nc2)cn1,,ClCCl,,,,val
US20050070562A1,CC(C)OC(=O)Cl.CS(=O)(=O)c1ccc(Nc2ncnc(OC3CCNCC3)c2[N+](=O)[O-])cc1>>CC(C)OC(=O)N1CCC(Oc2ncnc(Nc3ccc(S(C)(=O)=O)cc3)c2[N+](=O)[O-])CC1,,CN(C)C=O,,CCN(CC)CC,,val
US20090156610A1,O=C1CC(c2cccc(Cl)c2)C2(C(=O)Nc3cc(Cl)ccc32)C(c2cc(I)ccc2OC2CCNCC2)N1.OCCBr>>O=C1CC(c2cccc(Cl)c2)C2(C(=O)Nc3cc(Cl)ccc32)C(c2cc(I)ccc2OC2CCN(CCO)CC2)N1,,CCO,,CCN(CC)CC,,val
US20110021515A1,C[Mg]Br.O=C1OCc2c1nc(Cl)nc2N1CC2CCC(C1)O2>>CC1(O)OCc2c(N3CC4CCC(C3)O4)nc(Cl)nc21,,C1CCOC1,,,,val
US20090069287A1,CC(C)c1cccc(C2(N=[N+]=[N-])CCN(C(=O)OCc3ccccc3)C2)c1>>CC(C)c1cccc(C2(N)CCNC2)c1,[Pd],CCO,,[H][H],,val
US04912104,CCCCn1c(=O)n(CCC)c(=O)c2c(NC)n(CCCCl)nc21>>CCCCn1c(=O)n(CCC)c(=O)c2c3n(nc21)CCCN3C,,CN(C)C=O,,[H-].[Na+],,val
US05886178,CON(C)C(=O)c1ccc(Cl)cc1.Cc1ccc(Cl)cc1Cl>>Cc1ccc(Cl)c(C(=O)c2ccc(Cl)cc2)c1Cl,,C1CCOC1,,[Li]CCCC,,val
US04866057,CN1CC2=C(Cl)C=CN=C3C=CC(=CC#N)CC32C1.CN1CCNCC1>>CN1CCN(C2=C3CN(C)CC34CC(=CC#N)C=CC4=NC=C2)CC1,,CN(C)C=O,,,,val
US20150166543A1,CCc1cc(NC(=O)NCCNC(=O)OC(C)(C)C)ccc1Cc1c[nH]c2ccccc12>>CCc1cc(NC(=O)NCCN)ccc1Cc1c[nH]c2ccccc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US04734418,CCN1CCc2nc(N3CCN(Cc4ccccc4)CC3)ncc2C1=O>>CCN1CCc2nc(N3CCNCC3)ncc2C1=O,[Pd],CCO,,[H][H],,val
US20140350019A1,Cc1cc(CNc2c(C)ccc(OCC(=O)OC(C)C)c2C)cc(-c2cccc(F)c2)c1>>Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1,,C1CCOC1,,[Li+].[OH-],,val
US20150080365A1,CC(C)(C)OC(=O)N1CCCNCC1.Cc1ccnc(Br)c1>>Cc1ccnc(N2CCCN(C(=O)OC(C)(C)C)CC2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06265585B1,CN1COCNC1=N[N+](=O)[O-].Clc1ncc(CBr)s1>>CN1COCN(Cc2cnc(Cl)s2)C1=N[N+](=O)[O-],,ClCCl,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100216827A1,CCOC(=O)C(C)(C)Cc1cc(F)c(OC)c(F)c1>>CCOC(=O)C(C)(C)Cc1cc(F)c(O)c(F)c1,,ClCCl,,BrB(Br)Br,,val
US05693636,COC(=O)CC1Nc2ccc(NC(=O)c3ccc(C=NN)cc3)cc2CN(CCc2ccccc2)C1=O>>COC(=O)CC1=Nc2ccc(NC(=O)c3ccc(C=NN)cc3)cc2CN(CCc2ccccc2)C1=O,,CS(C)=O,,,,val
US20100286211A1,Nc1ccc(Br)cc1F.O=C(Cl)c1ccccc1>>O=C(Nc1ccc(Br)cc1F)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20100121052A1,CC(C)(C)OC(=O)N1CCC(Oc2cc3nc(Nc4cccc(-c5cnco5)c4)ncc3cc2C#CCO)CC1>>CC(C)(C)OC(=O)N1CCC(Oc2cc3nc(Nc4cccc(-c5cnco5)c4)ncc3cc2C#CC=O)CC1,O=[Mn]=O,ClCCl,,,,val
US20020099069A1,CCCCCCCCCI.CN1CC[C@H]2CCc3ccncc3[C@H]21>>CCCCCCCCC[n+]1ccc2c(c1)[C@@H]1[C@H](CC2)CCN1C.[I-],,CC(=O)O,,,,val
US20110144105A1,CN(C)C(=O)COc1cnc2c(c1)cc(C(=CC1CCCC1)c1ccc(S(C)(=O)=O)cc1)n2S(=O)(=O)c1ccccc1>>CN(C)C(=O)COc1cnc2[nH]c(C(=CC3CCCC3)c3ccc(S(C)(=O)=O)cc3)cc2c1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20060167020A1,CCOC=C(C#N)C#N.COc1cccc(NN)n1>>COc1cccc(-n2ncc(C#N)c2N)n1,,CCO,,CCN(CC)CC,Cl,val
US20110224262A1,COc1cccc(C2C(=S)NN=C2c2ccccc2)c1.N#CCBr>>COc1cccc(-c2c(-c3ccccc3)n[nH]c2SCC#N)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040147589A1,CI.O=C1Cc2ccc(OCc3ccccc3)cc2N1>>CN1C(=O)Cc2ccc(OCc3ccccc3)cc21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060074115A1,COc1ccc(COC(c2ccc(O[C@@H](Cc3ccccc3)C(=O)OCc3ccccc3)c(C)c2)(C(F)(F)F)C(F)(F)F)cc1>>COc1ccc(COC(c2ccc(O[C@H](CO)Cc3ccccc3)c(C)c2)(C(F)(F)F)C(F)(F)F)cc1,,C1CCOC1,CO,O,[BH4-].[Na+],val
US20150018560A1,CC1(C)CC/C(=C\c2ccc(Cl)cc2)C12CO2>>CC1(C)CCC(Cc2ccc(Cl)cc2)=C1CO,,Cc1ccccc1,,Cl,,val
US20030073847A1,ClCC=C(Cl)Cl.Oc1cc(Cl)c(OCCCOc2ccc(C(F)(F)F)cn2)c(Cl)c1>>FC(F)(F)c1ccc(OCCCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)nc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130245261A1,C[C@@H](Oc1nc(Nc2ccc(S(=O)(=NC(=O)C(F)(F)F)C3CC3)cc2)ncc1C(F)(F)F)[C@@H](C)OCc1ccccc1>>C[C@@H](Oc1nc(Nc2ccc(S(=O)(=NC(=O)C(F)(F)F)C3CC3)cc2)ncc1C(F)(F)F)[C@@H](C)O,[Pd],CCO,,,,val
US04775675,CC(C)(S)[C@@H](N)C(=O)O.O=Cc1ccccc1O>>CC1(C)SC(c2ccccc2O)N[C@H]1C(=O)O,,CO,,,,val
US20070099955A1,COc1c(C)ccc2c1C[C@@H](C1CCN(CCC(C)NC(=O)c3ccc(Cl)cc3)CC1)O[C@H]2CN.ClB(Cl)Cl>>Cc1ccc2c(c1O)C[C@@H](C1CCN(CCC(C)NC(=O)c3ccc(Cl)cc3)CC1)O[C@H]2CN.Cl.Cl,,ClCCl,,,,val
US04843087,CI.OCc1cc(CCCCCOc2c(Cl)cc(C3=NCCO3)cc2Cl)on1>>COCc1cc(CCCCCOc2c(Cl)cc(C3=NCCO3)cc2Cl)on1,,C1CCOC1,CCOCC,[H][H],[H-].[Na+],val
US20090069400A1,Cc1ccc(S(=O)(=O)OC2CCCC2)cc1.N#Cc1ccc(-c2c[nH]c3cc([N+](=O)[O-])ccc23)cc1>>N#Cc1ccc(-c2cn(C3CCCC3)c3cc([N+](=O)[O-])ccc23)cc1,,CS(C)=O,,[K+].[OH-],,val
US20050143422A1,CC#C[Sn](CCCC)(CCCC)CCCC.CCOC(=O)c1oc2cccc(OS(=O)(=O)C(F)(F)F)c2c1C>>CC#Cc1cccc2oc(C(=O)OCC)c(C)c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCCCCC,CCOC(C)=O,val
US04267175,COc1cc(NC(C)=O)c(Cl)cc1C(=O)O.NN1CCN(Cc2cccs2)CC1>>COc1cc(NC(C)=O)c(Cl)cc1C(=O)NN1CCN(Cc2cccs2)CC1,,[Na+],[OH-],O=S(Cl)Cl,,val
US20050059831A1,COC(=O)OC1OC(=O)C(Cl)=C1Cl.Cc1cccc(O)c1>>Cc1cccc(OC2OC(=O)C(Cl)=C2Cl)c1,[Pd],ClCCl,,,,val
US20050203064A1,Cc1cc(O)ccc1CCCCn1ccnn1.O=S(c1ccc(C=Cc2nc(CCl)co2)cc1)C(F)(F)F>>Cc1cc(OCc2coc(/C=C/c3ccc(S(=O)C(F)(F)F)cc3)n2)ccc1CCCCn1ccnn1,,CCC(C)=O,,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20080070867A1,O=c1[nH]ccn1Cc1ccccc1>>O=C1NCCN1Cc1ccccc1,[Pd],CO,,,,val
US05164402,CC(=O)NC12CNCC1C2.CCN(CC)CC.O=C(O)c1cn(-c2ccc(F)cc2F)c2nc(Cl)c(F)cc2c1=O>>CCOC(=O)c1cn(-c2ccc(F)cc2F)c2nc(N3CC4CC4(NC(C)=O)C3)c(F)cc2c1=O,,CC#N,,,,val
US20100273779A1,CC(C)I.COc1ccc(-c2n[nH]c(=O)c3ccsc23)cc1>>COc1ccc(-c2nn(C(C)C)c(=O)c3ccsc23)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070099911A1,O=c1[nH]ccc2c1ccc1[nH]cc(CCNCCc3ccccc3)c12>>CNCCc1c[nH]c2ccc3c(=O)[nH]ccc3c12,[Pd],,,,,val
US20100286165A1,COc1ccc(C2(N3CCN(c4ccncc4)CC3)C(=O)Nc3ccc(Cl)cc32)c(OC)c1.O=S(=O)(Cl)c1cccc2cccnc12>>COc1ccc(C2(N3CCN(c4ccncc4)CC3)C(=O)N(S(=O)(=O)c3cccc4cccnc34)c3ccc(Cl)cc32)c(OC)c1,,CN(C)C=O,,O,CC(C)(C)[O-].[K+],val
US20090297476A1,CC[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)NS(=O)(=O)C1CC1>>CC[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)C1CC1,,C1COCCO1,Cl,,,val
US20110112096A1,Cc1cc(Nc2nc(Nc3ccc(C4CCNCC4)c4ccccc34)ncc2Cl)n[nH]1.FC(F)(F)C1CO1>>Cc1cc(Nc2nc(Nc3ccc(C4CCN(CC(O)C(F)(F)F)CC4)c4ccccc34)ncc2Cl)n[nH]1,,CN(C)C=O,,,,val
US04244888,C#CCBr.CC12CCC(CC1=NO)C2(C)C>>C#CCON=C1CC2CCC1(C)C2(C)C,,CO,,[Na],,val
US20120220572A1,COC(=O)c1ccc(Nc2ncc3c(=O)n(-c4c(Cl)cccc4Cl)c4nccn4c3n2)cc1>>O=C(O)c1ccc(Nc2ncc3c(=O)n(-c4c(Cl)cccc4Cl)c4nccn4c3n2)cc1,,CO,O,[K+].[OH-],,val
US20090221555A1,COC1CNCCc2ccc([N+](=O)[O-])cc21.COCCBr>>COCCN1CCc2cc(OC)c([N+](=O)[O-])cc2CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150291582A1,Cc1cc(CCl)cnc1COCC(F)(F)F.Clc1nccc2n[nH]cc12>>Cc1cc(Cn2cc3c(Cl)nccc3n2)cnc1COCC(F)(F)F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05843983,COCOc1cc(Cl)ccc1CO.ClC(Cl)(Cl)Cl>>COCOc1cc(Cl)ccc1CCl,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20110237791A1,BrC1CC1.Sc1cccc(Br)c1>>Brc1cccc(SC2CC2)c1,,CS(C)=O,,O,CC(C)(C)[O-].[K+],val
US04824958,COc1c(C(=O)O)sc(C)c1C.Nc1nnn[nH]1>>COc1c(C(=O)Nc2nnn[nH]2)sc(C)c1C,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20090270411A1,O=C1c2ccccc2C(=O)N1CCBr.c1cc(N2CCNCC2)ccn1>>O=C1c2ccccc2C(=O)N1CCN1CCN(c2ccncc2)CC1,,CN(C)C=O,,[I-].[K+],,val
US20020045654A1,CC(=O)c1ccc(-c2ccco2)c(C)c1.CCOC(=O)C(F)(F)F>>Cc1cc(C(=O)CC(=O)C(F)(F)F)ccc1-c1ccco1,,COC(C)(C)C,,Cl,C[O-].[Na+],val
US20080090801A1,CN.Cc1nc(S(C)=O)nc2c1cc(Br)c(=O)n2C(C)C>>CNc1nc(C)c2cc(Br)c(=O)n(C(C)C)c2n1,,C1COCCO1,,,,val
US20060211712A1,CC(C)(C)OC(=O)Cn1c(=O)n(-c2ccccn2)c2ccccc21>>O=C(O)Cn1c(=O)n(-c2ccccn2)c2ccccc21,,CCOC(C)=O,,Cl,,val
US20060074084A1,Cc1cccc(-c2c(C(=O)O)[nH]c3ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)cc23)c1.NCCO>>Cc1cccc(-c2c(C(=O)NCCO)[nH]c3ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)cc23)c1,,CO,ClCCl,,,val
US20020193367A1,CC(C)(C)OC(=O)Nc1cc(Cl)c(C(F)(F)F)cc1[N+](=O)[O-].CNC1CC1>>CN(c1cc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])cc1C(F)(F)F)C1CC1,,CS(C)=O,,CCN(CC)CC,Cl,val
US20080153852A1,FC(F)(F)c1cc[nH]n1.OC(c1ccccc1I)C(F)(F)F>>OC(c1ccccc1-n1ccc(C(F)(F)F)n1)C(F)(F)F,[Cu]I,CCOC(C)=O,Cc1ccccc1,CN[C@@H]1CCCC[C@H]1NC,O=C([O-])[O-].[K+].[K+],val
US04115288,C#CCCCCC.C[Si](C)(C)N=[N+]=[N-]>>CCCCCc1c[nH]nn1,,CCOCC,,,,val
US20160039809A1,CCN(C(C)C)C(C)C.O=C(O)c1cccc(C(F)(F)F)c1Cl.O=C(O)c1ccnc(C(F)(F)F)c1F.c1cnc(-n2nnc3c2CCNC3)nc1>>C[C@H]1c2nnn(-c3ncc(F)cn3)c2CCN1C(=O)c1ccnc(C(F)(F)F)c1F,,CCN(CC)CC,,,,val
US20090306066A1,CN(C)C1CCN(Cc2ccccc2)C1(C)C>>CN(C)C1CCNC1(C)C,[Pd],CO,,Cl,,val
US20140054499A1,CCCC1CCC(C2CCC(=O)CC2)C1.CCOc1ccc(Br)c(F)c1F>>CCCC1CCC(C2CCC(O)(c3ccc(OCC)c(F)c3F)CC2)C1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20060194968A1,CCc1nc2c(OCc3ccccc3)cc(C(=O)N(C)C)cc2n1C>>CCc1nc2c(O)cc(C(=O)N(C)C)cc2n1C,[Pd],CCO,,CC(=O)O,,val
US05017724,Cc1cc(C)c2c(c1O)C(=O)C1CCCCC21.NO>>Cc1cc(C)c2c(c1O)C(=NO)C1CCCCC21,,c1ccncc1,,Cl,,val
US20080051418A1,CC(C)c1nc(CCCO)c(Cc2ccc(Cl)cc2Cl)s1.COC(=O)Cc1cccnc1O>>CC(C)c1nc(CCCOc2ncccc2CC(=O)O)c(Cc2ccc(Cl)cc2Cl)s1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20110077265A1,BrP(Br)Br.C#Cc1ccc(CO)cc1>>C#Cc1ccc(CBr)cc1,,ClCCl,,,,val
US20110172202A1,CC(C)(C)OC(=O)N[C@@H]1CCc2c(C#N)cccc21.CC(C)(C)[Si](C)(C)OCCBr>>CC(C)(C)OC(=O)N(CCO[Si](C)(C)C(C)(C)C)[C@@H]1CCc2c(C#N)cccc21,,CN(C)C=O,,[H-].[Na+],,val
US20160068559A1,CC1(C)O[C@@H]2[C@H](O1)[C@@H](CN(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)C1CCC1)O[C@H]2n1cnc2c(N)ncnc21>>CC(C)(C)c1ccc(NC(=O)NCCCN(C[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)C2CCC2)cc1,,CO,Cl,,,val
US05358859,CC(=O)OC[C@@H](OC(C)=O)[C@H]1O[C@@](OC(C)=O)(C(=O)OCc2ccccc2)C[C@@H](OC(C)=O)[C@H]1OC(C)=O>>CC(=O)OC[C@@H](OC(C)=O)[C@H]1O[C@@](OC(C)=O)(C(=O)O)C[C@@H](OC(C)=O)[C@H]1OC(C)=O,[Pd],CCO,,,,val
US20160137595A1,C=CC(c1ccccc1)c1cc(Br)cc([N+](=O)[O-])c1O.CCCI>>C=CCOc1c(C(C=C)c2ccccc2)cc(Br)cc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150038574A1,CC1=C(C=O)C(C)(C)CCC1.Cc1cccc(N)c1>>CC1=C(CNc2cccc(C)c2)C(C)(C)CCC1,,CO,,CC(=O)O,[Na],val
US20040220216A1,CN1CCN(S(=O)(=O)c2ccc3c(ccn3C(=O)OC(C)(C)C)c2)CC1.COB(OC)OC>>CN1CCN(S(=O)(=O)c2ccc3c(c2)cc(B(O)O)n3C(=O)OC(C)(C)C)CC1,,C1CCOC1,CCCCC,[Li]C(C)(C)C,,val
US20130296375A1,COCCC(=O)Cl.COc1ccnc(C(=O)N[C@H]2COC[C@H](OCC(C)C)[C@@H](OCC(C)C)[C@H](C)OC2=O)c1O>>COCCC(=O)Oc1c(OC)ccnc1C(=O)N[C@H]1COC[C@H](OCC(C)C)[C@@H](OCC(C)C)[C@H](C)OC1=O,CN(C)c1ccncc1,ClCCl,,,,val
US20150080549A1,C=C(CCC(=O)OC(C)(C)C)c1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N2CCCCC2)cc1.O=C(OCC1c2ccccc2-c2ccccc21)ON1C(=O)CCC1=O>>C=C(CCC(=O)O)c1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)N2CCCCC2)cc1,,C1COCCO1,O,CC(=O)O,,val
US20130281433A1,Brc1csc(Br)n1.CC(C)N1CCNCC1>>CC(C)N1CCN(c2nc(Br)cs2)CC1,,C1COCCO1,,,,val
US20040259896A1,Br.CC(C)c1ccccc1O>>CC(C)c1cc(Br)ccc1O,,CC(=O)O,O,CS(C)=O,,val
US20130267510A1,COCOc1cccc2c1C1CC1(C)CO2>>CC12COc3cccc(O)c3C1C2,,CO,,Cl,,val
US20160102058A1,OC(C1CCC(F)CC1)C1CCC(F)CC1>>O=C(C1CCC(F)CC1)C1CCC(F)CC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090306066A1,CNCc1ccncc1.Cc1nc(Cl)c(F)c(Cl)n1.NN>>Cc1nc(NN)c(F)c(N(C)Cc2ccncc2)n1,,CS(C)=O,,CCN(CC)CC,O,val
US05789595,CC1CN(C(=O)OCc2ccccc2)CCC1OCC(=O)OC(C)(C)C>>CC1CN(C(=O)OCc2ccccc2)CCC1OC=C=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090163469A1,COC(=O)[C@@H]1C[C@@H](N(C)C)CN1.N>>CN(C)[C@H]1CN[C@H](C(N)=O)C1,,CO,,,,val
US04180583,CC(C)(C)c1ccc(C(=O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1.Cl>>CC(C)(C)c1ccc(C(=O)CCCN2CCC(=C(c3ccccc3)c3ccccc3)CC2)cc1.Cl,,CCCCO,,O,,val
US05110815,CC1(C)CC(=O)c2ccc(=O)[nH]c2C1.CI>>Cn1c2c(ccc1=O)C(=O)CC(C)(C)C2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040152893A1,CC(=O)COc1cc(NC(=O)OC(C)(C)C)ccc1Cl.CNC>>CC(COc1cc(N)ccc1Cl)N(C)C,,CO,,Cl,[BH3-]C#N.[Na+],val
US20090156642A1,CN(Cc1cc(-c2cccnc2F)c(S(=O)(=O)c2ncc[nH]2)s1)C(=O)OC(C)(C)C.Cl>>CNCc1cc(-c2cccnc2F)c(S(=O)(=O)c2ncc[nH]2)s1.Cl,,CCO,CCOC(C)=O,,,val
US20050171356A1,BrC(Br)(Br)Br.OCCCOc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl>>ClC(Cl)=CCOc1cc(Cl)c(OCCCBr)c(Cl)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US07763657B2,ClI.Nc1ccccc1C(F)(F)F>>Nc1ccc(I)cc1C(F)(F)F,,ClCCl,,,,val
US20050130954A1,C[C@H]1CCc2c(ncnc2N2CCN(C(=O)OC(C)(C)C)CC2)N1.Cl>>C[C@H]1CCc2c(ncnc2N2CCNCC2)N1.Cl,,C1COCCO1,ClCCl,,,val
US20090312381A1,COc1ccccc1C(=O)NN.O=C=NC1CC1>>COc1ccccc1C(=O)NNC(=O)NC1CC1,,C1CCOC1,,,,val
US20090143361A1,COc1ccc2nc(C)c3c(C)nc(-c4cc(Cl)cc(Cl)c4)n3c2n1.N#Cc1ccc(B(O)O)cc1>>COc1ccc2nc(C)c3c(C)nc(-c4ccc(C#N)cc4)n3c2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US05241064,C=C(C(=O)OC)C(C)O.CC(=O)Cl>>C=C(C(=O)OC)C(C)OC(C)=O,,ClCCl,,c1ccncc1,,val
US20100249189A1,CC(C)(CCO)CC(CO[N+](=O)[O-])O[N+](=O)[O-].O=C(Oc1ccc([N+](=O)[O-])cc1)O[C@@H]1CO[C@@H]2[C@H](O)CO[C@H]12>>CC(C)(CCOC(=O)O[C@@H]1CO[C@@H]2[C@H](O)CO[C@H]12)CC(CO[N+](=O)[O-])O[N+](=O)[O-],CN(C)c1ccncc1,ClCCl,,,,val
US20060155121A1,Cc1cc(N)cc(C)c1[N+](=O)[O-].O=Cc1ccc(C(F)(F)F)cc1>>Cc1cc(NCc2ccc(C(F)(F)F)cc2)cc(C)c1[N+](=O)[O-],,CCO,,O,,val
US20060264622A1,C(=NC1CCCCC1)=NC1CCCCC1.ClCCl.O=C(Nc1ccccc1C(=O)O)OC/C=C/c1ccccc1>>O=C(Nc1ccccc1C(=O)N1CCC(CO)C1)OC/C=C/c1ccccc1,CN(C)C=O,ClCCl,,On1nnc2ccccc21,,val
US05436224,C=NC(C)(C)c1cccc(Cl)c1.CC1=C(c2ccccc2F)C(=O)OC(C)(C)O1>>CC1=C(c2ccccc2F)C(=O)N(C(C)(C)c2cccc(Cl)c2)CO1,,Cc1ccccc1C,,,,val
US20150152052A1,CCOC(=O)[C@@H]1CCCN(C(=O)c2ccc(NC(c3ccc(-n4cc5c(n4)CCCC5)cc3C)C(C)C)cc2)C1>>Cc1cc(-n2cc3c(n2)CCCC3)ccc1C(Nc1ccc(C(=O)N2CCC[C@@H](C(=O)O)C2)cc1)C(C)C,,CCO,,C1CCOC1,[Na+].[OH-],val
US20140350030A1,CCO.O=C(NC12CCCC(C(=O)[O-])(CC1)C2)OCc1ccccc1>>COC(=O)C12CCCC(N)(CC1)C2,[Pd],,,,,val
US20140336503A1,NC1CCCCC1.O=C(NCCc1ccc(OCc2ccccc2)cc1)c1cnc(Cl)nc1Cl>>O=C(NCCc1ccc(OCc2ccccc2)cc1)c1cnc(Cl)nc1NC1CCCCC1,,C1CCOC1,,,,val
US05371101,C[C@@H](OC1CCCCO1)C1(c2ccc(F)cc2F)CO1>>C[C@@H](O)C1(c2ccc(F)cc2F)CO1,,CCO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20110294781A1,Clc1cc(N2CCOCC2)n2nc(-c3ccccc3)cc2n1.NN>>NNc1cc(N2CCOCC2)n2nc(-c3ccccc3)cc2n1,,C1COCCO1,,O,O,val
US06479477B1,CCOC(=O)c1c2nc(c(CC)c3ccc([nH]3)c(C(=O)OCC)c3nc(c(CC)c4ccc1[nH]4)C=C3)C=C2.CN(C)C=O>>c1c[nH]c(Cc2ccc[nH]2)c1,,CN(C)C=O,,,,val
US20140336388A1,O=c1[nH]nc(C2CCN(c3ccc(/N=C/c4ccc([N+](=O)[O-])o4)cc3F)CC2)o1>>O=c1[nH]nc(C2CCN(c3ccc(NCc4ccc([N+](=O)[O-])o4)cc3F)CC2)o1,CC(=O)O,CO,,[BH3-]C#N.[Na+],,val
US20150284382A1,CC(C)(O)[C@H](F)CN.C[C@@H](CF)Nc1cc(Cl)ncc1C(=O)O>>C[C@@H](CF)Nc1cc(Cl)ncc1C(=O)NC[C@@H](F)C(C)(C)O,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110319378A1,CC[C@@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)N1C(=O)[C@H](CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1.C[Si](C)(C)C=[N+]=[N-]>>CC[C@@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)N1C(=O)[C@H](CC(=O)OC)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1,,ClCCl,,CO,,val
US20010034454A1,COc1cc(OC)cc(C(=O)Cl)c1.COc1ccc(-c2cc3ccc(OC)cc3s2)cc1>>COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2cc(OC)cc(OC)c2)cc1,,CCOC(C)=O,ClCCl,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20130059832A1,Cc1ccc(C#N)cc1NC(=O)c1cnc2ccccn12.NO>>Cc1ccc(C(N)=NO)cc1NC(=O)c1cnc2ccccn12,,CCO,,,,val
US20110245205A1,Cc1cc(N)cc(-c2cnc(C(C)(O)C(F)(F)F)s2)c1.O=C(O)c1ccnc(Cl)n1>>Cc1cc(Nc2nccc(C(=O)O)n2)cc(-c2cnc(C(C)(O)C(F)(F)F)s2)c1,,C1COCCO1,,CC(=O)O,,val
US20060178510A1,COC1=CC=C(C[C@@H]2CN(C(=O)OC(C)(C)C)CCO2)CC1=NO>>COC1=CC=C(C[C@@H]2CNCCO2)CC1=NO,,O=C(O)C(F)(F)F,,,,val
US06075036,C#CC(C)=O.CCc1c(-c2ccc(OC)cc2)cn2ccc(OC)cc12>>CCc1c(-c2ccc(OC)cc2)c2cc(C(C)=O)c3cc(OC)cc1n32,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US06784186B1,CC(C)(C)[Si](C)(C)Oc1ccc2c3c1OC1C(O[Si](C)(C)C(C)(C)C)C=C[C@H]4[C@@H](C2)N(CCCN)CC[C@]314.N=C(N)n1cccn1>>CC(C)(C)[Si](C)(C)Oc1ccc2c3c1OC1C(O[Si](C)(C)C(C)(C)C)C=C[C@H]4[C@@H](C2)N(CCCNC=NN)CC[C@]314,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20140357642A1,CCOC(=O)CCCCCCN1CC(CC)Cc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc21>>CCC1Cc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc2N(CCCCCCC(=O)O)C1,,C1CCOC1,O,[Li]O,,val
US20110319378A1,CC[C@@H](C=O)N1C(=O)[C@@](C)(CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1.FC1(F)CNC1>>CC[C@@H](CN1CC(F)(F)C1)N1C(=O)[C@@](C)(CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1,,ClCCCl,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120010190A1,COc1ccc(C(=O)CC(c2ccc(OC)nc2)c2ccccc2Cl)cn1>>O=C(CC(c1ccc(=O)[nH]c1)c1ccccc1Cl)c1ccc(=O)[nH]c1,,C1COCCO1,,Cl,,val
US20110275608A1,CCI.CCOc1ncccc1C(=O)O>>CCOC(=O)c1cccnc1OCC,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120208819A1,CCOC(=O)c1cccnc1NCc1cc(OC(C)C)cc(-c2cn(S(=O)(=O)c3ccccc3)c3ncc(Br)cc23)c1.OB(O)c1ccn[nH]1>>CCOC(=O)c1cccnc1NCc1cc(OC(C)C)cc(-c2cn(S(=O)(=O)c3ccccc3)c3ncc(-c4ccn[nH]4)cc23)c1,,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20120225844A1,CCOC(=O)c1cc(COc2ccccc2)nn1CCBr.C[C@@H](N)C1CC1>>C[C@H](C1CC1)N1CCn2nc(COc3ccccc3)cc2C1=O,,CC#N,,[I-].[K+],,val
US20120040954A1,CC(=O)N(C(C)C)C1CCNCC1.O=Cc1ccc(F)cc1>>CC(=O)N(C(C)C)C1CCN(c2ccc(C=O)cc2)CC1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20080269291A1,BrCc1ccccc1.CCS(=O)(=O)N1CCC(c2cn(C(=O)OC(C)(C)C)c3c(C(=O)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc(O)cc23)CC1>>CCS(=O)(=O)N1CCC(c2cn(C(=O)OC(C)(C)C)c3c(C(=O)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc(OCc4ccccc4)cc23)CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080300242A1,Cc1cc(O)ccc1[N+](=O)[O-].O=C(OCc1ccccc1)N1CCC(O)CC1>>Cc1cc(OC2CCN(C(=O)OCc3ccccc3)CC2)ccc1[N+](=O)[O-],,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160068559A1,CC1(C)O[C@@H]2[C@H](O1)[C@@H](CN(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)CC1CC1)O[C@H]2n1cnc2c(N)ncnc21>>CC(C)(C)c1ccc(NC(=O)NCCCN(CC2CC2)C[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)cc1,,O=C(O)C(F)(F)F,,O,O=C([O-])[O-].[K+].[K+],val
US20120058988A1,CC1(C)OB(Cc2ccccc2)OC1(C)C.N#Cc1cc(Br)ccc1Nc1ccc(C(=O)N2CCOCC2)cc1>>N#Cc1cc(Cc2ccccc2)ccc1Nc1ccc(C(=O)N2CCOCC2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20060128729A1,CCOC(=O)c1cnn(-c2ccccc2)c1NC(=O)c1ccc(F)cc1>>O=C(Nc1c(C(=O)O)cnn1-c1ccccc1)c1ccc(F)cc1,,C1COCCO1,O,[Na+].[OH-],,val
US20160168142A1,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O=C(O)c1cccnc1>>Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O=C([O-])c1cccnc1,,CO,,,,val
US20100127220A1,Cc1ccc(C)o1.O=C1C=CC(=O)O1>>CC12C=CC(C)(O1)C1C(=O)OC(=O)C12,,CCOCC,,,,val
US20070219261A1,COC(=O)c1scc(C)c1N.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1sccc1NC(=O)C(F)(F)F,,ClCCl,,Cl,c1ccncc1,val
US20080249102A1,COC(=O)N[C@H](C(=O)NN(Cc1ccc(Br)cc1)C[C@@](O)(Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O)C(C)(C)C.OB(O)c1ccncc1>>COC(=O)N[C@H](C(=O)NN(Cc1ccc(-c2ccncc2)cc1)C[C@@](O)(Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O)C(C)(C)C,,COCCOC,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20140051676A1,FC(F)(F)CCI.O=C(O)c1ccc(S)nc1>>O=C(O)c1ccc(SCCC(F)(F)F)nc1,,CCO,,CC(=O)[O-].[Na+],,val
US20050267095A1,CCN1CCC(O)CC1.Oc1ccc(C2(CNc3ccccn3)CCOCC2)cc1>>CCN1CCC(Oc2ccc(C3(CNc4ccccn4)CCOCC3)cc2)CC1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04329351,BrCc1ccccc1.N#Cc1cc(O)cnc1Cl>>N#Cc1cc(OCc2ccccc2)cnc1Cl,,CN(C)C=O,,O,[H-].[Na+],val
US20070167433A1,COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)C[C@@H](O)[C@@H]3c3ccc(COC[C@@H](C)COC)cc3)cc21.Cc1ccc(S(=O)(=O)OCCN(C)S(=O)(=O)c2ccc(C)cc2)cc1>>COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)C[C@@H](OCCN(C)S(=O)(=O)c4ccccc4)[C@@H]3c3ccc(COC[C@@H](C)COC)cc3)cc21,,C1CCOC1,COC(C)(C)C,[H-].[Na+],,val
US20120082702A1,CCOC(=O)c1cnc(Cl)cc1Cl.Nc1ccc(C(=O)N2CCOCC2)cc1>>CCOC(=O)c1cnc(Cl)cc1Nc1ccc(C(=O)N2CCOCC2)cc1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20060004046A1,CCCc1c(C#N)cnc2ccc(C=O)cc12.COc1ccc(/C=C2\SC(=N)NC2=O)cc1OC1CCCC1>>CCCc1c(C#N)cnc2ccc(/C=C3\SC(N)=NC3=O)cc12,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20100120857A1,OCCCC#Cc1cc(C#CCCCO)cc(C#CCCCO)c1>>OCCCCCc1cc(CCCCCO)cc(CCCCCO)c1,[Pd],CO,,,,val
US20100119503A1,COC(=O)C1(C(C)(C)O)C=C[C@@H](NC(=O)OC(C)(C)C)C1>>COC(=O)C1(C(C)(C)O)CC[C@H](NC(=O)OC(C)(C)C)C1,,CCO,,,,val
US20020037886A1,CS(=O)(=O)Cl.OCCCc1c[nH]c2ccccc12>>CS(=O)(=O)OCCCc1c[nH]c2ccccc12,,C1CCOC1,,CCN(CC)CC,,val
US20120245152A1,C[C@H](Oc1ncc(F)cc1NC1CCN(C(=O)OC(C)(C)C)CC1)C(=O)OC(C)(C)C>>C[C@@H]1Oc2ncc(F)cc2N(C2CCNCC2)C1=O,,O=C(O)C(F)(F)F,,,,val
US20110166158A1,O=[N+]([O-])c1cc(F)cc(I)c1.Oc1cncnc1>>O=[N+]([O-])c1cc(I)cc(Oc2cncnc2)c1,,Cl,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050267049A1,CCNC(=O)C#Cc1ccc(N2C(=O)[C@H](CC[C@H](OC(C)=O)c3ccc(F)cc3)[C@H]2c2ccc(O[C@@H]3O[C@H](C(=O)OC)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)cc2)cc1>>CCNC(=O)C#Cc1ccc(N2C(=O)[C@H](CC[C@H](O)c3ccc(F)cc3)[C@H]2c2ccc(O[C@@H]3O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]3O)cc2)cc1,,CO,,[C-]#N.[Na+],,val
US20070129353A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cccc2sc(N)nc12>>Cc1c(N)ccc2sc(C(=O)OC(C)(C)C)nc12,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,,val
US20160229816A1,N#Cc1[nH]nnc1-c1cc(C(F)(F)F)ccc1/C=C/c1ccccc1>>N#Cc1[nH]nnc1-c1cc(C(F)(F)F)ccc1CCc1ccccc1,[Pd],CCO,,,,val
US20070073055A1,C1COCCN1.Clc1ccccc1>>c1ccc(N2CCOCC2)cc1,,COCCOC,,CC(C)(C)[O-].[K+],,val
US20090072200A1,CCCCCCCCCCC(=O)CSc1cccs1>>CCCCCCCCCCc1csc2sccc12,,Clc1ccccc1,,,,val
US05162188,C[N+](C)(CCNC(=O)c1ccccc1)Cc1ccccc1.O=[N+]([O-])c1cccc(S(=O)(=O)[O-])c1>>C[N+](C)(CCNC(=O)c1ccccc1)Cc1ccccc1.O=[N+]([O-])c1cccc(S(=O)(=O)[O-])c1,,O,,[Cl-].[Na+],,val
US20120101110A1,CO.O=C1N(Cc2c[nH]c3ncccc23)CCCC12CCN(c1cncc(Cl)n1)CC2>>COc1cncc(N2CCC3(CCCN(Cc4c[nH]c5ncccc45)C3=O)CC2)n1,,CO,,C[O-].[Na+],,val
US20080096860A1,NS(N)(=O)=O.c1cnc(N2CCNCC2)nc1>>NS(=O)(=O)N1CCN(c2ncccn2)CC1,,C1COCCO1,,,,val
US20150284367A1,CC(C)c1nc(Nc2cc(Cl)nnc2C(N)=O)ccc1F.NCCN>>CC(C)c1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1F,,CN1CCCC1=O,,[NH4+].[OH-],,val
US20060025432A1,C[C@H]1CNC[C@@H](C)N1.NS(N)(=O)=O>>C[C@H]1CN(S(N)(=O)=O)C[C@@H](C)N1,,C1COCCO1,,,,val
US20150056141A1,CCOC(=O)c1c(NC(C)=O)sc2c(OCCN(CC)CC)c(Br)ccc12.OB(O)c1ccsc1>>CCOC(=O)c1c(NC(C)=O)sc2c(OCCN(CC)CC)c(-c3ccsc3)ccc12,,CC#N,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20040029814A1,COC(=O)c1cccc(OCCC(C#N)NC(=O)[C@H](Cc2cccc(C)c2)NC(=O)C(c2ccccc2)c2ccccc2)c1>>Cc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NC(C#N)CCOc2cccc(C(=O)O)c2)c1,,C1CCOC1,O,[Li]O,,val
US20140256707A1,COc1ccc(CN(c2ncns2)S(=O)(=O)c2ccc3c(-c4cccc5c4CN(C(=O)OC(C)(C)C)CC5)cn(C)c3c2)c(OC)c1>>Cn1cc(-c2cccc3c2CNCC3)c2ccc(S(=O)(=O)Nc3ncns3)cc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140235647A1,CC1(C)OB(c2cncc3ccccc23)OC1(C)C.N#Cc1cccc(Br)c1F>>Cc1ccncc1-c1cccc(C#N)c1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20120202834A1,CCCC(Oc1ccc(-n2cnc(C(F)(F)F)c2)cc1)c1ccc(C(=O)OC)cc1>>CCCC(Oc1ccc(-n2cnc(C(F)(F)F)c2)cc1)c1ccc(C(=O)O)cc1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20030119807A1,CN(C)CCCN(C)C(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)O)n1.C[Si](C)(C)ON>>CN(C)CCCN(C)C(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)NO)n1,,CO,ClCCl,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20060264460A1,CCc1nc(C)c(C=O)[nH]1.N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(Cl)c1>>CCc1nc(C)c(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)[nH]1,,CCO,,[BH3-]C#N.[Na+],,val
US03971819,CC(=O)NS(=O)(=O)c1cc(C(=O)O)cc(N)c1Oc1ccccc1.O=Cc1ccccc1>>CC(=O)NS(=O)(=O)c1cc(C(=O)O)cc(NCc2ccccc2)c1Oc1ccccc1,O=[Pt],CC(=O)O,,[H][H],,val
US20090105482A1,CCOC(=O)CS.Nc1ncc(Br)s1>>CCOC(=O)CSc1cnc(N)s1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20110152322A1,CCCN.CCOC(=O)C(C#N)=C(Cl)c1cccnc1Cl>>CCCN/C(=C(/C#N)C(=O)OCC)c1cccnc1Cl,,C1CCOC1,,,,val
US04062862,C(=CCc1ccccc1)Cc1ccccc1.O=C(OO)c1ccccc1>>C1=CC2OC2(CC=CCc2ccccc2)C=C1,,ClC(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20160159751A1,CS(=O)(=O)Nc1ccc(-c2nc(NCC(c3ccccc3)c3ccccn3)c3ccccc3n2)cc1.CS(=O)(=O)Nc1ccc(B(O)O)cc1.Clc1nc(NCC(c2ccncc2)c2ccncc2)c2ccccc2n1>>CS(=O)(=O)Nc1ccc(-c2nc(NCC(c3ccncc3)c3ccncc3)c3ccccc3n2)cc1,,CO,ClC(Cl)Cl,,,val
US20060241302A1,CCOC(=O)CS(=O)(=O)Nc1cc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)c(Cl)cn1.N>>NC(=O)CS(=O)(=O)Nc1cc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)c(Cl)cn1,,CO,,,,val
US20060004017A1,COc1cc2c(Oc3ccc4[nH]cc(C)c4c3)ncnc2cc1O.ClCCCN1CCOCC1>>c1ncc2ccc(OCCCN3CCOCC3)cc2n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160060273A1,CCOC(=O)C1(C)CCN(C2=NOC3(C2)CN(Cc2cc(C4CC4)c(C4CC4)c(F)c2OC(C)C)C3)CC1>>CC(C)Oc1c(CN2CC3(CC(N4CCC(C)(C(=O)O)CC4)=NO3)C2)cc(C2CC2)c(C2CC2)c1F,,CCO,,[Na+].[OH-],,val
US20070135461A1,CC(C)(CCO)n1cc(-c2ncnc3[nH]ccc23)cn1.CS(=O)(=O)Cl>>CC(C)(CCOS(C)(=O)=O)n1cc(-c2ncnc3[nH]ccc23)cn1,,ClCCl,,,,val
US20110306592A1,CC(C)(C)OC(=O)N1CC(NC(=O)CNc2noc3ccc(C(F)(F)F)cc23)C1.O=C(O)C(F)(F)F>>O=C(CNc1noc2ccc(C(F)(F)F)cc12)NC1CNC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20070208018A1,COC(=O)c1cc(N2CCSCC2)c(C(F)(F)F)cc1[N+](=O)[O-]>>COC(=O)c1cc(N2CCSCC2)c(C(F)(F)F)cc1N,[Ni],CCO,,,,val
US20100105667A1,CS(=O)(=O)OS(C)(=O)=O.O=[N+]([O-])c1ccc(CO)nc1>>CS(=O)(=O)OCc1ccc([N+](=O)[O-])cn1,,ClCCl,,CCN(CC)CC,,val
US20100016352A1,COCCl.COc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1Cl>>COCOc1cc(O)c2c(=O)cc(-c3ccc(OC)c(Cl)c3)oc2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20110245205A1,BrBr.OC(c1nccs1)(C1CC1)C1CC1>>OC(c1ncc(Br)s1)(C1CC1)C1CC1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20110294850A1,CCCN(CCC)C(=O)c1cc2cc(OC)ccc2n1Cc1ccccc1>>CCCN(CCC)C(=O)C1Cc2cc(OC)ccc2N1Cc1ccccc1,,CCOC(C)=O,CO,[Mg],,val
US20110230521A1,CC1CCNCC1.Cc1c(C(=O)N[C@@H](CCCC(=O)O)c2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)cc1>>Cc1c(C(=O)N[C@@H](CCCC(=O)N2CCC(C)CC2)c2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)cc1,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US03956374,CC(=O)C(CC=Cc1ccccc1C)c1ccccc1.O=Cc1ccc(Cl)cc1>>Cc1ccccc1C=CCC(C(=O)C=Cc1ccc(Cl)cc1)c1ccccc1,,CCO,,[Na+].[OH-],,val
US20090105225A1,COC(=O)c1ccncc1C(=O)Cc1ccc(Cl)cc1.NN>>Clc1ccc(Cc2nncc3ccncc23)cc1,CC(=O)O,CCO,,O,,val
US20050267149A1,COC(=O)c1ccccc1CBr.O=C(CCc1ccc(O)cc1)N1CCc2ccccc2C1>>COC(=O)c1ccccc1COc1ccc(CCC(=O)N2CCc3ccccc3C2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090082356A1,Clc1nc2ccccc2nc1Cl.NS(=O)(=O)c1cccc(F)c1>>O=S(=O)(Nc1nc2ccccc2nc1Cl)c1cccc(F)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04018748,Cl.O=C(O)c1nonc1C(=O)O.O=S(Cl)Cl>>O=C(Cl)c1nonc1C(=O)Cl,,CN(C)C=O,,,,val
US20030203915A1,CC(C)(S)CN.O=C(O)c1ccccc1>>CC(C)(S)CNC(=O)c1ccccc1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20060122168A1,CCC(O)C(NC(=O)OC(C)(C)C)C(=O)O.O=[N+]([O-])c1ccccc1F>>CCC(Oc1ccccc1[N+](=O)[O-])C(NC(=O)OC(C)(C)C)C(=O)O,,CN(C)C=O,,[H-].[Na+],,val
US05153214,CC(C)(C)ONS(=O)(=O)C1C=CC(Cl)=CC1=C=O.COC(=O)CC[C@@H](CCCCO)CCCc1cccnc1>>COC(=O)CC[C@@H](CCCCN(OC(C)(C)C)S(=O)(=O)C1C=CC(Cl)=CC1=C=O)CCCc1cccnc1,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04855323,COC(=O)CCS.c1ccc(COc2c(CC3CO3)cccc2C2CCCC2)cc1>>COC(=O)CCSCC(O)Cc1cccc(C2CCCC2)c1OCc1ccccc1,,CO,,CCN(CC)CC,,val
US20150133432A1,COCOc1ccc(-c2cc(CNC3CCN(C(=O)OC(C)(C)C)CC3(C)C)c3c(C)nn(C4CCCCO4)c3n2)cc1>>Cc1n[nH]c2nc(-c3ccc(O)cc3)cc(CNC3CCNCC3(C)C)c12,,C1COCCO1,,Cl,,val
US20070032485A1,CC1(C)OB(c2cncc(C=O)c2)OC1(C)C.CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(I)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC>>CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(-c3cncc(C=O)c3)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20110144140A1,Cc1cc(Cl)nc(-c2cccc(Cl)n2)n1.Nc1ccc(Cl)cc1>>Cc1cc(Nc2ccc(Cl)cc2)nc(-c2cccc(Cl)n2)n1,,CC#N,,CCN(CC)CC,,val
US05399561,CC(C)=CC(=O)Cl.Oc1ccc(Br)cc1>>CC(C)=CC(=O)Oc1ccc(Br)cc1,,C1CCOC1,,[H-].[Na+],,val
US20070037807A1,CS(=O)(=O)Cl.Cc1ccc(-c2c(CO)c(C)nc(CC(C)(C)C)c2CNC(=O)OC(C)(C)C)cc1>>Cc1ccc(-c2c(COS(C)(=O)=O)c(C)nc(CC(C)(C)C)c2CNC(=O)OC(C)(C)C)cc1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20100324086A1,C[C@H](NC(=O)c1cccc(NC(=O)OC(C)(C)C)c1)c1cccc2ccccc12>>C[C@H](NC(=O)c1cccc(N)c1)c1cccc2ccccc12,,O=C(O)C(F)(F)F,,,,val
US20110046169A1,CCOC=C(C(=O)OCC)C(=O)OCC.Cc1ccccc1NN>>CCOC(=O)c1c[nH]n(-c2ccccc2C)c1=O,,O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20160264579A1,CCC(C(=O)Cl)C(=O)Cl.Nc1ccccc1.O>>CCOC(=O)CC(N)=O,CN(C)c1ccncc1,,,CCN(CC)CC,ClCCl,val
US06166040,CC1(C)C(=O)N(CCOS(C)(=O)=O)c2ccccc21.Fc1cccc2c(C3=CCNCC3)c[nH]c12>>CC1(C)C(=O)N(CCN2CC=C(c3c[nH]c4c(F)cccc34)CC2)c2ccccc21,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US05578607,Cc1ccc(C)c2ncccc12.O=[N+]([O-])O>>Cc1c([N+](=O)[O-])cc(C)c2ncccc12,,O=S(=O)(O)O,,[NH4+].[OH-],,val
US20130281434A1,Cc1cc2nc(-c3ccc(-c4ccc5cnn(C)c5c4)nc3)sc2c(-c2ccc(Cl)cc2)c1[C@@H](CO)OC(C)(C)C.O.[Cr+6].[O-2].[O-2].[O-2].[O-][I+3]([O-])([O-])O>>Cc1cc2nc(-c3cncc(-c4ccc5c(cnn5C)c4)c3)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O.[Cr+6].[O-2].[O-2].[O-2].[O-][I+3]([O-])([O-])O,,O,,CC#N,,val
US20070142413A1,CCOc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc(Cl)c2Cl)n[nH]1.NC[C@@H](O)CO>>CCOc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc(NC[C@@H](O)CO)c2Cl)[nH]n1,,CCCCO,,,,val
US20070054892A1,COc1ccc2c(=O)n(CC3CC(NC(=O)OC(C)(C)C)CCN3)c(C#N)c(-c3ccccc3)c2c1.Cl>>COc1ccc2c(=O)n(CC3CCNCC3)c(C#N)c(-c3ccccc3)c2c1.Cl,,CCOC(C)=O,,,,val
US20020065276A1,ClCC#CCCl.O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNC[C@H]1Cc1c[nH]c2ccccc12>>O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC#CCCl)C[C@H]1Cc1c[nH]c2ccccc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04199568,CC(C)CC[NH-].CCCSC>>CSCCCNCCC(C)C,,C1CCOC1,CO,Cl,,val
US20100261724A1,COC(=O)Cc1ccc(-c2nccnc2C2CC2)cc1>>O=C(O)Cc1ccc(-c2nccnc2C2CC2)cc1,,CO,,Cl,[Li+].[OH-],val
US20010000038A1,CC(C)(C(=O)O)c1ccccc1.NC(=O)N1CCCC1.O=C(Cl)CCCCl>>CC(C)(C(=O)O)c1ccc(C(=O)CCCCl)cc1.NC(=O)N1CCCC1,,ClC(Cl)(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20090181956A1,CC(C)(C)NN.CCOC(=O)C(=CN(C)C)C(=O)c1ccccc1Cl>>CCOC(=O)c1cnn(C(C)(C)C)c1-c1ccccc1Cl,,O,,CCO,Cl,val
US20080070928A1,Fc1ccc(Oc2cc(Oc3cccnc3)cc3[nH]c(S)nc23)cc1.NN>>NNc1nc2c(Oc3ccc(F)cc3)cc(Oc3cccnc3)cc2[nH]1,,CCOC(C)=O,,O,,val
US20030100554A1,CC(C)(C)[Si](C)(C)Cl.Cc1nn(CCO)c(C)c1Oc1cc(Cl)cc(Cl)c1>>Cc1nn(CCO[Si](C)(C)C(C)(C)C)c(C)c1Oc1cc(Cl)cc(Cl)c1,,CN(C)C=O,,O,c1c[nH]cn1,val
US05786379,COCCOCOc1ccc(C(=O)Cl)cc1C12CC3CC(CC(C3)C1)C2.O=C(O)c1ccc(S)cc1>>COCCOCOc1ccc(C(=O)Sc2ccc(C(=O)O)cc2)cc1C12CC3CC(CC(C3)C1)C2,,c1ccncc1,,,,val
US20070161686A1,CI.Cc1onc(-c2ccccc2)c1-c1nnc(-c2ccc3[nH]ccc3c2)o1>>Cc1onc(-c2ccccc2)c1-c1nnc(-c2ccc3c(ccn3C)c2)o1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US07629363B2,Cc1cc(O)cc(=O)o1.Nc1cc(CO)ccc1Cl>>Cc1cc(O)cc(=O)n1-c1cc(CO)ccc1Cl,,Clc1ccccc1Cl,,,,val
US20150045349A1,Nc1cccc(Br)n1.O=CO>>O=CNc1cccc(Br)n1,,C1CCOC1,,CC(=O)OC(C)=O,,val
US20140228409A1,CCCn1c2c(c3cc([N+](=O)[O-])ccc31)CCCC2>>CCCn1c2c(c3cc(N)ccc31)CCCC2,[Pd],CCOC(C)=O,,CO,[H][H],val
US20060220004A1,CCN(CC)S(F)(F)F.OC(c1cccc(Br)n1)(c1cccc(Br)n1)c1cccc(Br)n1>>FC(c1cccc(Br)n1)(c1cccc(Br)n1)c1cccc(Br)n1,,ClCCl,O,[Na+].[OH-],,val
US20160244444A1,N#Cc1ccc(N2CCc3c(ncnc3Nc3ccc([N+](=O)[O-])cn3)C2)cc1C(F)(F)F>>N#Cc1ccc(N2CCc3c(ncnc3Nc3ccc(N)cn3)C2)cc1C(F)(F)F,[Pd],CO,,,,val
US20030166639A1,CCc1cnc(C)cc1-c1cccc(C(=O)CC(=O)Nc2cc(C(F)(F)F)ccc2NC(=O)OC(C)(C)C)c1>>CCc1cnc(C)cc1-c1cccc(C2=Nc3ccc(C(F)(F)F)cc3NC(=O)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05739116,CC(=O)c1ccc(O)cc1.CCOC(=O)CCCBr>>CCOC(=O)CCCOc1ccc(C(C)=O)cc1,,CN(C)C=O,,[I-].[K+],,val
US20160095858A1,COc1ccc(CN2CCC(S(=O)(=O)NC(=O)c3ccc(-c4cc(F)cc(OCC(C)C)c4)nc3N3CC(C)CC3(C)C)C2=O)cc1>>CC(C)COc1cc(F)cc(-c2ccc(C(=O)NS(=O)(=O)C3CCNC3=O)c(N3CC(C)CC3(C)C)n2)c1,,ClCCl,O=C(O)C(F)(F)F,O=S(=O)(O)C(F)(F)F,,val
US20020004503A1,COC(=O)[C@@H](N)C(C)C.O=C(Cl)CCCBr>>COC(=O)[C@@H](NC(=O)CCCBr)C(C)C,,ClCCl,,c1ccncc1,,val
US20100137313A1,CCS(N)(=O)=O.COc1ncc(-c2cnc(Nc3cc(C)cc(C)c3)nc2-n2ccc(C(F)(F)F)n2)cc1C(=O)O>>CCS(=O)(=O)NC(=O)c1cc(-c2cnc(Nc3cc(C)cc(C)c3)nc2-n2ccc(C(F)(F)F)n2)cnc1OC,CN(C)c1ccncc1,ClCCl,ClCCl,CCN(CC)CC,C[n+]1ccccc1Cl.[I-],val
US20150274733A1,COC(=O)CN(C(=O)OCc1ccccc1)C(C)(C)CC(=O)OC>>COC(=O)C1C(=O)CC(C)(C)N1C(=O)OCc1ccccc1,,Cc1ccccc1,,CC(C)(C)[O-].[K+],,val
US20040229949A1,CCOC(=O)C(Cc1ccc(OCCc2ccc(N(C)C(=O)C(C)C)cc2)cc1)OCC>>CCOC(Cc1ccc(OCCc2ccc(N(C)C(=O)C(C)C)cc2)cc1)C(=O)O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20150045368A1,Cc1cc(N2C(=O)OC(C)(C)[C@@H]2c2ccccc2)ccc1C(=O)O.O=S(Cl)Cl>>Cc1cc(N2C(=O)OC(C)(C)[C@@H]2c2ccccc2)ccc1C(=O)Cl,,ClCCl,,,,val
US06350907B1,COc1cccc(-c2ccc([N+](=O)[O-])cc2C)c1>>COc1cccc(-c2ccc(N)cc2C)c1,[Pd],CCO,CCOC(C)=O,,,val
US06121301,COC(=O)c1csc(N)n1.N#Cc1cccc(C(=O)Cl)c1>>COC(=O)c1csc(NC(=O)c2cccc(C#N)c2)n1.Cl,,ClCCCl,,,,val
US20090074738A1,Cc1cccc2c([C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc4ccccc4)[C@H](OCc4ccccc4)[C@H]3OCc3ccccc3)cn(Cc3ccc(/C=C/CC(=O)O)cc3)c12.OCCOCc1ccccc1>>Cc1cccc2c([C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc4ccccc4)[C@H](OCc4ccccc4)[C@H]3OCc3ccccc3)cn(Cc3ccc(/C=C/CC(=O)OCCOCc4ccccc4)cc3)c12,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20020173653A1,CCOCC(=O)Nc1cnc2cccnc2c1NCc1ccccc1>>CCOCc1nc2cnc3cccnc3c2n1Cc1ccccc1,,CO,,Cl,N,val
US20100305096A1,Nc1ccccc1Nc1nc(N2CCOCC2)c2nc(CN3CC(N4CCOCC4)C3)sc2n1.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]c2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CC(N4CCOCC4)C3)sc2n1,,C1COCCO1,,,,val
US20140163066A1,CC(C)(C)OC(=O)N[C@@H](c1ccccc1)c1cccc(O)c1.O=Cc1ccc(OCCBr)cc1>>CC(C)(C)OC(=O)N[C@@H](c1ccccc1)c1cccc(OCCOc2ccc(C=O)cc2)c1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080015191A1,CC(=O)Nc1cccc(O)c1.Clc1cncc(Cl)n1>>CC(=O)Nc1cccc(Oc2cncc(Cl)n2)c1,,CCOC(C)=O,,,,val
US20120245144A1,CC(C)(CO)N1CCC(Sc2ccc3c(c2)-c2nc(-c4ccccn4)cn2CCO3)CC1.O=C(OO)c1cccc(Cl)c1>>CC(C)(CO)N1CCC(S(=O)c2ccc3c(c2)-c2nc(-c4ccccn4)cn2CCO3)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccc(F)cc2)c1C#N.SCCc1ccccn1>>N#Cc1c(SCCc2ccccn2)nc(N)nc1-c1ccc(F)cc1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20030162788A1,CC1(C)CCN(c2ccc(CN)cc2)CC1.Cn1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1C(=O)O>>Cn1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1C(=O)NCc1ccc(N2CCC(C)(C)CC2)cc1,,C1CCOC1,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US04548948,Cc1cccc(C(=O)Cl)c1C.c1ccccc1>>Cc1cccc(C(=O)c2ccccc2)c1C,,CC(Cl)Cl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20090285772A1,CN(C)c1ccc2nccc(Cl)c2c1.Cc1cc(Nc2ccc(NC(=O)c3ccc(N)cc3)cc2)nc(N)n1.Cl>>Cc1cc(Nc2ccc(NC(=O)c3ccc(Nc4ccnc5ccc(N(C)C)cc45)cc3)cc2)nc(N)n1.Cl,,O,,CCO,Cl,val
US20050054638A1,COc1cccc(C=O)c1.NO>>COc1cccc(C=NO)c1,,O,,Cl,[Na+].[OH-],val
US20150158851A1,CC1(C)CCc2c(C(=O)O)nn(COCC[Si](C)(C)C)c2C1.CSCC(c1ccccc1)n1cc(N)cn1>>CSCC(c1ccccc1)n1cc(NC(=O)c2nn(COCC[Si](C)(C)C)c3c2CCC(C)(C)C3)cn1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140045872A1,OCc1cc2cc(F)ccc2s1>>O=Cc1cc2cc(F)ccc2s1,O=[Mn]=O,CCCCCC,ClCCl,CCOC(C)=O,,val
US20150284395A1,COC(=O)c1ccc(Cl)c(OCC(F)(F)F)c1>>O=C(O)c1ccc(Cl)c(OCC(F)(F)F)c1,,CO,O,[Na+].[OH-],,val
US20070213338A1,Clc1nnc(OCc2cccc(CNCCc3ccccc3)n2)c2ccccc12.OB(O)c1ccccn1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>c1ccc(CCNCc2cccc(COc3nnc(-c4cccnc4)c4ccccc34)n2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US07129268B2,O=C(CBr)c1cccs1.O=Cc1cc(Br)ccc1O>>Brc1ccc2oc(Cc3cccs3)cc2c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06093732,CCOC(=O)c1cnc2ccc(CC#N)cc2c1O.NCc1ccc(Cl)cc1>>N#CCc1ccc2ncc(C(=O)NCc3ccc(Cl)cc3)c(O)c2c1,,CCOCC,ClCCl,,,val
US06342511B1,CC1CCCNC1.O=C(O)C(O)c1ccccc1>>C[C@H]1CCCNC1.O=C(O)C(O)c1ccccc1,,CCOC(C)=O,,,,val
US20150336979A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O[C@@H]1CO[C@@H]2[C@@H](C#Cc3ccc4c(c3)OCO4)CO[C@H]12>>O=S(=O)(O[C@@H]1CO[C@@H]2[C@@H](C#Cc3ccc4c(c3)OCO4)CO[C@H]12)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US20160024091A1,COC1CN(C2=C(C)C(=O)OC2)C(=O)C12CCN(C(=O)OC(C)(C)C)CC2>>COC1CN(C2=C(C)C(=O)OC2)C(=O)C12CCNCC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130203776A1,COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC[C@H](O)CCl)c2n1>>COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCC(=O)CCl)c2n1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US04113940,CC1C=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(NC(=O)Cn3cnnn3)[C@H]2S1>>CC1C=C(C(=O)O)N2C(=O)C(NC(=O)Cn3cnnn3)[C@H]2S1,[Zn],CC(=O)O,,CN(C)C=O,,val
US20100041646A1,CC(C)(C)[Si](C)(C)OCCCN(C#N)c1ccc(N2C[C@H](CNC(=O)c3ccc(Cl)s3)OC2=O)cc1.CS(=O)(=O)O>>CS(=O)(=O)O.N=C1OCCCN1c1ccc(N2C[C@H](CNC(=O)c3ccc(Cl)s3)OC2=O)cc1,,CC#N,,,,val
US05459270,CC(=O)Cl.Cc1cc(C)cc(CO[C@H]2CCCN[C@H]2c2ccccc2)c1>>Cc1cc(C)cc(CO[C@H]2CCCN[C@H]2c2ccccc2)c1.Cl,,CO,,,,val
US05908955,CCCCCCCCCCCCCl.Nc1cc(C(=O)O)ccc1Cl>>CCCCCCCCCCCCOC(=O)c1ccc(Cl)c(N)c1,,CCOC(C)=O,O,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20140315886A1,CCOc1ccc2nc(-c3cccnc3)nc(O)c2c1.O=P(Cl)(Cl)Cl>>CCOc1ccc2nc(-c3cccnc3)nc(Cl)c2c1,,Cc1ccccc1,,,,val
US20030114437A1,C[C@@H]1CC[C@H](NC(=O)[C@H](CC2CCCCC2)NC(=O)OC(C)(C)C)[C@@H](O)CN1C(=O)OCc1ccccc1>>C[C@@H]1CC[C@H](NC(=O)[C@H](CC2CCCCC2)NC(=O)OC(C)(C)C)[C@@H](O)CN1,[Pd],CCO,,[H][H],,val
US20070066624A1,Cc1cccc(N)n1.O=C1CCC(=O)N1Br>>Cc1nc(N)ccc1Br,,CO,,,,val
US20030170561A1,O=S(=O)([O-])C(F)(F)C(F)(F)C1CC2CCC1C2.c1ccc([S+](c2ccccc2)c2ccccc2)cc1>>O=S(=O)([O-])C(F)(F)C(F)(F)C1CC2CCC1C2.c1ccc([S+](c2ccccc2)c2ccccc2)cc1,,O,,[Cl-].[Na+],,val
US04740228,CC(C#N)(C(=O)Cl)c1ccccc1.NC1CCCCC1>>CC(C#N)(C(=O)NC1CCCCC1)c1ccccc1,,CC(C)=O,,CCN(CC)CC,,val
US04061746,CCCCCCCCCCCCN.O=C1CCCCCCN1>>CCCCCCCCCCCCN=C1CCCCCCN1,,c1ccccc1,,O=P(Cl)(Cl)Cl,,val
US20130116243A1,CC(C)(C)OC(=O)NCc1ccc(-c2nc3c(cc2-c2ccccc2)N(CC(F)(F)F)C(=O)CO3)cc1>>NCc1ccc(-c2nc3c(cc2-c2ccccc2)N(CC(F)(F)F)C(=O)CO3)cc1,,O=C(O)C(F)(F)F,,,,val
US04263037,CC1(C)C(=O)Oc2ccc(C#N)cc21.CNC>>CN(C)C(=O)C(C)(C)c1cc(C#N)ccc1O,,CCO,CCOCC,,,val
US20130231352A1,Br[Mg]c1ccccn1.CON(C)C(=O)c1cc(F)ccc1N>>Nc1ccc(F)cc1C(=O)c1ccccn1,,C1CCOC1,ClCCl,CC(C)[Mg]Cl,,val
US20110135671A1,CCC[C@H](C)Oc1nc(N)c2nc(OC)n(CCCCCN3CCN(C(=O)OC(C)(C)C)CC3)c2n1>>CCC[C@H](C)Oc1nc(N)c2[nH]c(=O)n(CCCCCN3CCNCC3)c2n1,,CO,,C1COCCO1,Cl,val
US05175157,COc1cc2c(cc1OC)CC(=O)N(CC1CCCN(CCc3cncc4cc(OC)c(OC)cc34)C1)C=C2>>COc1cc2c(cc1OC)CC(=O)N(CC1CCCN(CCc3cncc4cc(OC)c(OC)cc34)C1)CC2,[Pd],CCO,,[H][H],,val
US20160214971A1,CCS(N)(=O)=O.COc1cc(C(=O)O)ccc1Br>>CCS(=O)(=O)NC(=O)c1ccc(Br)c(OC)c1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20100069436A1,CC(O)CN.COCCn1c(SC)nc(-c2ccc(F)cc2)c1-c1ccnc(F)c1>>COCCn1c(SC)nc(-c2ccc(F)cc2)c1-c1ccnc(NCC(C)O)c1,,CCOC(C)=O,,,,val
US20120129840A1,C1CCOC1.CCN(C(C)C)C(C)C.COC(=O)Cc1c(C)nc(-c2ccccc2)nc1-c1cccc(O)c1.COCBr>>CCCC(C(=O)OC)c1c(C)nc(-c2ccccc2)nc1-c1cccc(OCOC)c1,,C1CCOC1,,,,val
US05236958,COS(=O)(=O)c1ccc(C)cc1.Cc1ccc2[se]c(C)nc2c1>>Cc1ccc(S(=O)(=O)[O-])cc1.Cc1ccc2[se]c(C)[n+](C)c2c1,,ClC(Cl)Cl,,,,val
US04808727,CCc1n(Cc2cc(OC)c(OC)c(OC)c2)cc[n+]1N=Cc1ccccc1.[Cl-]>>CCc1n(Cc2cc(OC)c(OC)c(OC)c2)cc[n+]1N.[Cl-],,O,,Cl,,val
US20130317001A1,CC(C)(C)OC(=O)c1cc(C2CC2)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F>>O=C(O)c1cc(C2CC2)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140275086A1,Cn1cnc(S(=O)(=O)N2C[C@@H](CO)[C@H](c3ccc(F)cc3)C2)c1.Oc1ccccc1>>Cn1cnc(S(=O)(=O)N2C[C@@H](COc3ccccc3)[C@H](c3ccc(F)cc3)C2)c1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(Oc3ncns3)cc(C)c21>>Cc1cc(Oc2ncns2)cc2c1C(CC(=O)O)OB2O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20040063725A1,N#Cc1ccc(CCN)cc1.O=C(Cl)OCc1ccccc1>>CN(Cc1ccc(C#N)cc1)C(=O)OCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US08399433B2,CCOC1CCC(=O)CC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC1CC=C(OS(=O)(=O)C(F)(F)F)CC1,,ClCCl,,,,val
US04166128,CCBr.O=C(O)C(=O)c1ccccc1Nc1c(Cl)cccc1Cl>>CCOC(=O)C(=O)c1ccccc1Nc1c(Cl)cccc1Cl,,CN(C)C=O,,O,CC(=O)[O-].[Na+],val
US06015774,CCOC(=O)C(C)Br.Cn1c(C(F)(F)F)cnc(-c2ccc(F)c(N)c2)c1=O>>CCOC(=O)C(C)Nc1cc(-c2ncc(C(F)(F)F)n(C)c2=O)ccc1F,,O,,,,val
US20140179670A1,C[C@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)n1c(=O)ccn(-c2cccc(C(F)(F)F)c2)c1=O>>C[C@H](CO)n1c(=O)ccn(-c2cccc(C(F)(F)F)c2)c1=O,,CCO,,Cl,,val
US04874775,CS(=O)(=O)OS(C)(=O)=O.Fc1ccc(CNCc2cccnc2)cc1>>CS(=O)(=O)N(Cc1ccc(F)cc1)Cc1cccnc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20100129753A1,CCOC(C)=O.CCn1c2ccc(C(C)=O)cc2c2cc(C(=O)c3ccccc3C)ccc21>>CCn1c2ccc(C(=O)CC(C)=O)cc2c2cc(C(=O)c3ccccc3C)ccc21,,O,,Cl,CC(C)(C)[O-].[K+],val
US20120238549A1,CCC[C@@]1(O)CC[C@@]2(CC)c3ccc(C(=O)OC)cc3C(=O)CC[C@H]2C1.CCC[C@]1(O)CC[C@]2(CC)c3ccc(C(=O)OC)cc3C(=O)CC[C@@H]2C1>>CCC[C@@]1(O)CC[C@@]2(CC)c3ccc(C(=O)OC)cc3C(O)CC[C@H]2C1.CCC[C@]1(O)CC[C@]2(CC)c3ccc(C(=O)OC)cc3C(O)CC[C@@H]2C1,,CCO,,[BH4-].[Na+],,val
US20120010190A1,C1COCCN1.Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)O)cc1>>Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)N2CCOCC2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20150094297A1,CC(=O)c1nc(CO[Si](C)(C)C(C)(C)C)cs1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>C=C(OS(=O)(=O)C(F)(F)F)c1nc(CO[Si](C)(C)C(C)(C)C)cs1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20040192686A1,OB(O)c1ccccc1.[O-][n+]1nc(Cl)nc2ccccc21>>[O-][n+]1nc(-c2ccccc2)nc2ccccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040229949A1,CCOC(=O)C(Cc1ccc(OCCc2ccc(O)cc2)cc1)OCC.O=C=NCc1ccccc1>>CCOC(=O)C(Cc1ccc(OCCc2ccc(OC(=O)NCc3ccccc3)cc2)cc1)OCC,,ClCCl,,CCN(CC)CC,,val
US04898871,CN(C)C(=O)CCl.COc1ccc2ccc(N3C(=O)c4ccccc4C3O)nc2n1>>COc1ccc2ccc(N3C(=O)c4ccccc4C3OCC(=O)N(C)C)nc2n1,,CN(C)C=O,,[H-].[Na+],,val
US20150030626A1,CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)OCc1ccccc1>>CC(C)[C@H](N)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)OCc1ccccc1,,ClCCl,,C1CCNCC1,,val
US05723606,CI.Cc1nc2c([nH]1)-c1ccccc1N(C(=O)c1ccc([N+](=O)[O-])cc1)CC2>>Cc1nc2c(n1C)CCN(C(=O)c1ccc([N+](=O)[O-])cc1)c1ccccc1-2,,CN(C)C=O,ClC(Cl)Cl,O,[H-].[Na+],val
US20100076029A1,CCOC(=O)C(C)(C)SC(C)=O.Cc1ccc(S(=O)(=O)OC[C@H]2COCCO2)cc1>>CCOC(=O)C(C)(C)SC[C@H]1COCCO1,,CCO,,C[O-].[Na+],,val
US20100152450A1,COC(=O)CC(=O)[O-].O=Cc1cc(F)cc(I)c1>>COC(=O)C=Cc1cc(F)cc(I)c1,,c1ccncc1,,C1CCNC1,,val
US20110094966A1,C=C[C@H](NC(=O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1)c1ccccc1.C[SiH](C)Cl>>C[Si](C)(Cl)CC[C@H](NC(=O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1)c1ccccc1,,CC(C)O,ClCCl,,,val
US20050026989A1,COC(=O)c1cn(-c2ccc3ncccc3c2)c2ccccc12>>O=C(O)c1cn(-c2ccc3ncccc3c2)c2ccccc12,,C1CCOC1,O,[Li+].[OH-],,val
US06586633B1,CC(=O)c1cccc(CNC2CC2)c1.CC(C)(C)C#CC=CCBr>>CC(=O)c1cccc(CN(C/C=C/C#CC(C)(C)C)C2CC2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060178381A1,NC(N)=O.O=C(O)c1cc(F)c(C(F)(F)F)cc1C(=O)O>>Nc1cc2c(cc1C(F)(F)F)C(=O)NC2=O,,CCOC(C)=O,,CN1CCCC1=O,,val
US20120010183A1,CC(C)CB(O)O.Clc1cccnc1I>>CC(C)Cc1ncccc1Cl,O=[Ag],C1CCOC1,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20070167447A1,CNC.O=C(O)Cn1c(-c2ccccc2)c(C2CCCCC2)c2ccc(-c3noc(=O)[nH]3)cc21>>CN(C)C(=O)Cn1c(-c2ccccc2)c(C2CCCCC2)c2ccc(-c3noc(=O)[nH]3)cc21,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20060094767A1,CN(CC1(C)CO1)C(=O)OCc1ccc(F)cc1.O=[N+]([O-])c1c[nH]c(Cl)n1>>CN(CC(C)(O)Cn1cc([N+](=O)[O-])nc1Cl)C(=O)OCc1ccc(F)cc1,,CCO,,CC(=O)[O-].[Na+],,val
US04006144,CCOC(=O)N1CCNCC1.Cc1ccc2c(c1)CC(Cl)c1ccccc1S2>>CCOC(=O)N1CCN(C2Cc3cc(C)ccc3Sc3ccccc32)CC1,,ClC(Cl)Cl,,,,val
US05833885,CC(=O)C(C)C.CN(N)c1cc(C(F)(F)F)cc(C(F)(F)F)n1>>CC(=NN(C)c1cc(C(F)(F)F)cc(C(F)(F)F)n1)C(C)C,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20100093694A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cccc(C(=O)O)c3)cc12.CS(N)(=O)=O>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cccc(C(=O)NS(C)(=O)=O)c3)cc12,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20050038037A1,CCOC(=O)C1(Br)CCC1.CCOC(=O)N1CCN(C(=O)C(CCC(=O)OC(C)(C)C)NC(=O)c2cc(O)c3ccccc3n2)CC1.CN(C)C=O>>CCOC(=O)N1CCN(C(=O)C(CCC(=O)OC(C)(C)C)NC(=O)c2cc(OC3(C(=O)OCC)CCC3)c3ccc(C)cc3n2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070032478A1,Cn1nc(C(C)(C)C)cc1C(=O)Cl.Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3)c1>>Cn1nc(C(C)(C)C)cc1C(=O)Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3)c1,,C1CCOC1,,,,val
US20150210688A1,CI.COC(=O)c1cc(-c2nc3ccncc3[nH]2)c(C2CC2)cc1C>>COC(=O)c1cc(-c2nc3cc[n+](C)cc3[nH]2)c(C2CC2)cc1C.[I-],,ClCCl,,,,val
US20030130281A1,Cc1[nH]c(-c2ccccc2)nc1CCl.[N-]=[N+]=[N-]>>Cc1[nH]c(-c2ccccc2)nc1CN=[N+]=[N-],,CN(C)C=O,,Cl,,val
US05631286,C#CC1(c2ccc(OC(F)F)c(OC(F)F)c2)CCC(OC)(OC)CC1>>C#CC1(c2ccc(OC(F)F)c(OC(F)F)c2)CCC(=O)CC1,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140005146A1,COC(=O)c1coc(C(C)(C)[C@@H](C)N)n1.NC(=O)c1cnn2cc(Br)cc2c1Cl>>COC(=O)c1coc(C(C)(C)[C@@H](C)Nc2c(C(N)=O)cnn3cc(Br)cc23)n1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100076029A1,COC(=O)C(C)(C)C(C)=O>>COC(=O)C(C)(C)[C@H](C)O,,CO,,,,val
US20050070562A1,CC(C)CCCC(=O)O.Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1CCNCC1>>Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1CCN(C(=O)CCCC(C)C)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130261116A1,CNC(=O)c1ccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1F.OB(O)c1cccc(OCC(F)(F)F)c1>>FC(F)(F)COc1cccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20020045615A1,COC(=O)Nc1nc2c(OC)ccc(-c3ccnc(C)c3)c2s1>>COc1ccc(-c2ccnc(C)c2)c2sc(N)nc12,,O,OCCO,Cl,[K+].[OH-],val
US20140107149A1,CC(C)(C)OC(=O)NCC(=O)O.NCC(F)F>>CC(C)(C)OC(=O)NCC(=O)NCC(F)F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04762848,CC(=O)Nc1cnc(S)s1.O=C(O)CBr>>CC(=O)Nc1cnc(SCC(=O)O)s1,,CN(C)C=O,,,,val
US20060247320A1,CC(C)(C)C1CCc2nc(S)c(C#N)cc2C1.N#CCCl>>CC(C)(C)C1CCc2nc(SCC#N)c(C#N)cc2C1,,ClCCl,O,CCN(CC)CC,,val
US20110237573A1,CC(=O)N1CCN(c2ccc(NC(=O)Cc3cnc(Cl)c(Cl)c3)nc2)CC1.Cc1cc(B2OC(C)(C)C(C)(C)O2)ccn1>>CC(=O)N1CCN(c2ccc(NC(=O)Cc3cnc(-c4ccnc(C)c4)c(Cl)c3)nc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20110144090A1,CCn1cc(CC(=O)NC)c2c(OC)c(/C=C/C(=O)OC)cc(F)c21.CO>>CCn1cc(CC(=O)N(C)C)c2c(OC)c(CCC(=O)OC)cc(F)c21,[Pd],,,,,val
US20120058997A1,FC(F)(F)Oc1cccc(-c2cnc3ccc(Cl)nn23)c1.OCC1CCOCC1>>FC(F)(F)Oc1cccc(-c2cnc3ccc(COC4CCOCC4)nn23)c1,,C1COCCO1,,CC(C)(C)[O-].[K+],,val
US05011943,CC(=O)O.CCCCCC=CCc1ccccc1.O>>CCCCCC=C(O)O,,C1CCOC1,,CCOCC,,val
US20050026925A1,CCOC(=O)c1cc2cc(C)c(Cl)nc2[nH]1.C[C@H]1CN(C(=O)OC(C)(C)C)S(=O)(=O)O1>>CCOC(=O)c1cc2cc(C)c(Cl)nc2n1[C@H](C)CNC(=O)OC(C)(C)C,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US05496727,C=CC[C@@H]1C=C(C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC.C[Si](C)(C)CCOC(=O)CCCN=C=O.c1ccccc1>>CCCCCCCCCC=CCC(=O)CCCCCC(=O)CCCCCCC(=O)C(C)=O,CCN(CC)CC,,,,,val
US20100216746A1,CC(C)(C)OC(=O)c1nc2cc([N+](=O)[O-])ccc2[nH]1>>CC(C)(C)OC(=O)c1nc2cc(N)ccc2[nH]1,O=[Pt]=O,CCO,,,,val
US20040127574A1,CNC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)cc1.O=C(Cl)c1cccc2ccccc12>>CN(C(=O)c1cccc2ccccc12)C(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)cc1,,CCOC(C)=O,O,O=C([O-])O.[Na+],,val
US05681841,COC(=O)CCc1ccc(N(CCO)C(=O)Nc2ccc3c(c2)CCCC3=O)cc1>>COC(=O)CCc1ccc(N2CCN(c3ccc4c(c3)CCCC4=O)C2=O)cc1,,CC#N,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US03941803,C=O.Cc1cncn1-c1ccc(C(F)(F)F)cc1C(=O)c1ccccc1>>Cc1cnc(CO)n1-c1ccc(C(F)(F)F)cc1C(=O)c1ccccc1,,Cc1ccccc1C,,,,val
US20140179670A1,Cc1c(-c2ccsc2Br)c(=O)n(C)c(=O)n1-c1cccc(C(F)(F)F)c1.N#Cc1ccc(B(O)O)cc1>>Cc1c(-c2ccsc2-c2ccc(C#N)cc2)c(=O)n(C)c(=O)n1-c1cccc(C(F)(F)F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20160222148A1,C=CCN.CCN(C(C)C)C(C)C.CN(C)C=O.O=C(O)c1ccnc(-c2cc(C(=O)O)ccn2)c1>>C=CCNC(=O)c1ccnc(-c2cc(C(=O)NCC=C)ccn2)c1,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20140163025A1,CC(C)(O)CCn1ncc2ccc(OCc3ccccc3)cc21>>CC(C)(O)CCn1ncc2ccc(O)cc21,[Pd],CO,,,,val
US20090170913A1,CCCCc1ccc(C(=O)O)cc1.CN1CCC(N(C)c2nc3cc(N)ccc3o2)CC1>>CCCCc1ccc(C(=O)Nc2ccc3oc(N(C)C4CCN(C)CC4)nc3c2)cc1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20010006969A1,C=CCNCC=C.C=CCNc1nc(Cl)nc2ccc([N+](=O)[O-])cc12>>C=CCNc1nc(N(CC=C)CC=C)nc2ccc([N+](=O)[O-])cc12,,O,,,,val
US20090048258A1,CCc1ccc(C(=O)CCC(=O)O)s1.Nc1nc(-c2ccccc2)c(Cc2ccccc2)s1>>CCc1ccc(C(=O)CCC(=O)Nc2nc(-c3ccccc3)c(Cc3ccccc3)s2)s1,,CC#N,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US05179206,CC(C)C=O.CC1CCCC(C)N1N.[C-]#N>>CC(C)C(C#N)NN1C(C)CCCC1C,,CO,O,Cl,,val
US06399660B1,C[C@H](NCCc1ccc(OCC(=O)OCc2ccccc2)cc1Cl)[C@H](O)c1ccc(O)cc1.Cl>>C[C@H](NCCc1ccc(OCC(=O)OCc2ccccc2)cc1Cl)[C@H](O)c1ccc(O)cc1.Cl,,CCOC(C)=O,,,,val
US20040235822A1,CCCn1ccnc1CC(=O)c1ccc(N)cc1.NO>>CCCn1ccnc1C/C(=N\O)c1ccc(N)cc1,,CCO,,Cl,O=C([O-])O.[Na+],val
US04115385,CC1(C)S[C@@H]2C(N)C(=O)N2C1c1nnnn1Cc1ccc(OCc2ccccc2)cc1.O=C(Cl)Cc1ccccc1>>CC1(C)S[C@@H]2C(NC(=O)Cc3ccccc3)C(=O)N2C1c1nnnn1Cc1ccc(OCc2ccccc2)cc1,,ClC(Cl)Cl,,c1ccncc1,,val
US20150018547A1,COC(=O)CC(=O)CCl.Cc1cc(O)c(C)c(S)c1>>COC(=O)CC(=O)CSc1cc(C)cc(O)c1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060058337A1,CC1c2ccccc2-c2ccc(Cl)cc2N1C(=O)c1ccc(O)cc1>>C[C@@H]1c2ccccc2-c2ccc(Cl)cc2N1C(=O)c1ccc(O)cc1,,ClC(Cl)Cl,,,,val
US05958924,Cl.Nc1ccc2[nH]c(=O)cc(CCCl)c2c1.c1cc2sccc2c(N2CCNCC2)n1>>Cl.Nc1ccc2[nH]c(=O)cc(CCN3CCN(c4nccc5sccc45)CC3)c2c1,,CN(C)C=O,O,O=C([O-])O.[Na+],,val
US20040176410A1,C[S+](C)(C)=O.O=C1CCN(Cc2ccccc2)CC1>>c1ccc(CN2CCC3(CC2)CO3)cc1,,CS(C)=O,,[H-].[Na+],,val
US20160016903A1,CN(C)C1(c2ccc(F)s2)CCC2(CC1)CC(=O)N(C(=O)OC(C)(C)C)C2>>CN(C)C1(c2ccc(F)s2)CCC2(CC1)CNC(=O)C2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120295884A1,Brc1c[nH]c2ncncc12.CC(C)(C)OC(=O)CBr>>CC(C)(C)OC(=O)Cn1cc(Br)c2cncnc21,,CN(C)C=O,,O,[H-].[Na+],val
US20130116243A1,CN.CSC(SC)=C1CCc2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc2C1=O.NN>>CNc1[nH]nc2c1CCc1nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc1-2,,CCO,,O,,val
US20100029687A1,CCOC(=O)c1ccc(N=C=O)cc1.C[C@H](c1cccc2ccccc12)N(CC1CCNCC1c1ccccc1)C(=O)OC(C)(C)C>>CCOC(=O)c1ccc(NC(=O)N2CCC(CN(C(=O)OC(C)(C)C)[C@H](C)c3cccc4ccccc34)C(c3ccccc3)C2)cc1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20160045611A1,CC(=O)OC[C@@H]1O[C@H](OC(C)=O)[C@@H](O[C@H]2O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]2OC(=O)Nc2ccc([N+](=O)[O-])cc2)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(=O)OC[C@@H]1O[C@H](OC(C)=O)[C@@H](O[C@H]2O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]2OC(N)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,ClCCl,,N,,val
US20070105904A1,C#Cc1cccnc1N.ON=C(Cl)Cc1ccc(Oc2ccccc2)nc1>>Nc1ncccc1-c1cc(Cc2ccc(Oc3ccccc3)nc2)no1,,O,,C1CCOC1,CCN(CC)CC,val
US20040127514A1,CC(C)(C)C(=O)CBr.O=C(NCC1CCNCC1)OCc1ccccc1>>CC(C)(C)C(=O)CN1CCC(CNC(=O)OCc2ccccc2)CC1,,CN(C)C=O,,CCN(CC)CC,,val
US20160108056A1,COc1ccc(C(F)(F)F)c(Br)c1.Nc1cccc(B(O)O)c1>>COc1ccc(C(F)(F)F)c(-c2cccc(N)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20130178420A1,CCCCCCCOc1ccc(C(=O)CBr)cc1.COC(=O)[C@H](Cc1ccc(C(=O)O)cc1)NC(=O)c1ccc(C(C)(C)C)cc1>>CCCCCCCOc1ccc(C(=O)COC(=O)c2ccc(C[C@H](NC(=O)c3ccc(C(C)(C)C)cc3)C(=O)OC)cc2)cc1,,CC#N,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US05117057,CC(C)(C)N(NC(=O)c1ccccc1)C(=O)c1ccccc1.CI>>CN(C(=O)c1ccccc1)N(C(=O)c1ccccc1)C(C)(C)C,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20130065900A1,COC(=O)C(C(=O)OC)c1cc(OC)c([N+](=O)[O-])cc1Cl>>COc1cc(CCO)c(Cl)cc1[N+](=O)[O-],,CS(C)=O,,O,[Cl-].[Na+],val
US06005103,CC(C)(C)CC=O.O=c1oc(-c2ccccc2)cc(O)c1SSc1c(O)cc(-c2ccccc2)oc1=O.SC1CCCCC1>>CC(C)(C)CC(SC1CCCCC1)c1c(O)cc(-c2ccccc2)oc1=O,,CC(=O)O,CCO,C1CCNCC1,,val
US04286095,BrCc1ccccc1.c1ccc(C23CCNCC2O3)cc1>>c1ccc(CN2CCC3(c4ccccc4)OC3C2)cc1,,c1ccccc1,,CCN(CC)CC,,val
US03950393,CNC1CCCCC1.COc1ccc(N)c(CO)c1>>COc1ccc(N)c(CN(C)C2CCCCC2)c1,,ClCCl,,O=S(Cl)Cl,,val
US20030096788A1,CCc1cnc([C@H]2O[C@@H](n3cnc4c(Cl)ncnc43)[C@H](O)[C@@H]2O)o1.NC1CCOCC1>>CCc1cnc([C@H]2O[C@@H](n3cnc4c(NC5CCOCC5)ncnc43)[C@H](O)[C@@H]2O)o1,,CC(C)O,,CCN(C(C)C)C(C)C,Cl,val
US20090124676A1,CCCCCCC=C[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]2OC(=O)C[C@@H]21>>CCCCCCCC[C@H]1[C@H](O)C[C@@H]2OC(=O)C[C@@H]21,[Pd],CO,,,,val
US20100010035A1,CCc1cc2[nH]c(=O)ccc2c(CC)n1.COCCOCN(c1noc(C)c1C)S(=O)(=O)c1sc(C)cc1-c1ccc(COS(C)(=O)=O)cc1C>>CCc1cc2c(ccc(=O)n2Cc2ccc(-c3cc(C)sc3S(=O)(=O)N(COCCOC)c3noc(C)c3C)c(C)c2)c(CC)n1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20100130497A1,CCC#COc1ccc(C=O)cc1OC.O=C(O)CC(=O)Nc1ccccc1C(=O)O>>C#CCCOc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1OC,,Cc1ccccc1,,C1CCNCC1,Cl,val
US20030013743A1,NN=Cc1cccc(C(F)(F)F)c1.O=C(Cl)c1cccnc1Oc1cccnc1>>O=C(NN=Cc1cccc(C(F)(F)F)c1)c1cccnc1Oc1cccnc1,,C1CCOC1,CCN(CC)CC,,,val
US20050209260A1,COc1cc(NC(C)=O)ccc1C(C)=O.C[Mg]Cl>>COc1cc(NC(C)=O)ccc1C(C)(C)O,,C1CCOC1,,,,val
US05665777,OB(O)c1ccc(F)cc1.Oc1ccc(I)cc1>>Oc1ccc(-c2ccc(F)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05506234,COCc1c(C(=O)OC(C)C)ncc2[nH]c3ccc(C#Cc4ccc(Cl)cc4)cc3c12>>COCc1c(C(=O)OC(C)C)ncc2[nH]c3ccc(CCc4ccc(Cl)cc4)cc3c12,[Ni],CCO,,,,val
US20130005705A1,CCOC(=O)c1c(Br)ccnc1C.O=C1CCC(=O)N1Br>>CCOC(=O)c1c(Br)ccnc1CBr,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20060270628A1,CCOC(C)=O.NCc1cn(-c2ccc([N+](=O)[O-])cc2)nn1.S=C(Cl)Cl>>COC(=S)NCc1cn(-c2ccc([N+](=O)[O-])cc2)nn1,,CCOC(C)=O,ClC(Cl)Cl,O=C([O-])O.[Na+],,val
US06194410B1,CCc1nn2c(Cl)c3c(nc2c1S(=O)(=O)c1ccccc1)CCC3.N>>CCc1nn2c(N)c3c(nc2c1S(=O)(=O)c1ccccc1)CCC3,,CO,,,,val
US20040023974A1,O=C1NC(Cc2ccc([N+](=O)[O-])c(OCc3ccccc3)c2)C(=O)Nc2ccccc21>>Nc1ccc(CC2NC(=O)c3ccccc3NC2=O)cc1OCc1ccccc1,O=[Pt],CCOC(C)=O,CO,,,val
US20070167486A1,COC(=O)CCC1=CCN(CCCc2ccc(C)cc2)C1=O.NO[K]>>Cc1ccc(CCCN2CC=C(CCC(=O)NO)C2=O)cc1,,CO,ClC(Cl)Cl,CC(=O)O,,val
US05998461,CN=C=O.NCCc1coc2ccc3c(c12)CCCO3>>CNC(=O)NCCc1coc2ccc3c(c12)CCCO3,,c1ccncc1,,Cl,,val
US20150038523A1,CC(C)(C)OC(=O)NCCCOc1ccccc1CN=C=O.COC(=O)CNC(=O)c1csc(N)n1>>COC(=O)CNC(=O)c1csc(NC(=O)NCc2ccccc2OCCCNC(=O)OC(C)(C)C)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US05670505,C=CC(N)=O.O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNC[C@H]1Cc1c[nH]c2ccccc12>>NC(=O)CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1,,Cc1ccccc1,,,,val
US20010051620A1,N#Cc1cnc2cc3c(cc2c1Cl)ncn3CCN1CCOCC1.Nc1ccc(Oc2ccccc2)cc1>>N#Cc1cnc2cc3c(cc2c1Nc1ccc(Oc2ccccc2)cc1)ncn3CCN1CCOCC1,,CCOCCO,,Cl,c1ccncc1,val
US05990102,ICCCCc1ccccc1.O=C1CC(SCc2ccccc2)N1>>O=C1CC(SCc2ccccc2)N1CCCCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US05506267,CCCCCCCCCCCCCCCC(=O)Cl.CCCCCCCCCCCCCCCCCCNC(=O)OCC(O)CSCCC(=O)OC(C)(C)C>>CCCCCCCCCCCCCCCCCCNC(=O)OCC(CSCCC(=O)OC(C)(C)C)OC(=O)CCCCCCCCCCCCCCC,,ClCCl,,CN(C)c1ccccn1,,val
US20100069629A1,CCOC(=O)CCNC(=O)N1CCc2c(-c3cnc(N(Cc4ccc(OC)cc4)Cc4ccc(OC)cc4)nc3)nc(N3CCOCC3)nc21>>COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4C(=O)NCCC(=O)O)cn2)cc1,,C1CCOC1,,[Na+].[OH-],,val
US20070117839A1,CC(=O)OC(C)=O.COc1cc(/C=C2\CC[C@H]3CNC[C@@H](c4cc(F)c(F)c(F)c4)N3C2=O)ccc1-n1cnc(C)c1>>COc1cc(/C=C2\CC[C@H]3CN(C(C)=O)C[C@@H](c4cc(F)c(F)c(F)c4)N3C2=O)ccc1-n1cnc(C)c1,,c1ccncc1,,,,val
US05905090,CC(=O)Oc1ccccc1C(=O)Nc1ccc(C(F)(F)F)cc1>>O=C(Nc1ccc(C(F)(F)F)cc1)c1ccccc1O,,CO,,c1c[nH]cn1,,val
US20120035149A1,CCC(C)OC(=O)NCC(C)C(=O)N(Cc1cc(Cl)c2c(c1)OCCCO2)CC(C)C>>CC(C)CN(Cc1cc(Cl)c2c(c1)OCCCO2)C(=O)C(C)CN,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070037836A1,CC(C)(C)OC(=O)NC(NC[C@@H]1CC[C@@H](CNS(=O)(=O)c2ccc(Br)cc2OC(F)(F)F)CC1)NC(=O)OC(C)(C)C.ClCCl>>Cl.Cl.N=C(N)NC[C@@H]1CC[C@@H](CNS(=O)(=O)c2ccc(Br)cc2OC(F)(F)F)CC1,,O=C(O)C(F)(F)F,,,,val
US05306692,CCOC(=O)C(C)n1ncc2ccc(O)cc21.Fc1cc(C(F)(F)F)cc(Cl)c1F>>CCOC(=O)C(C)n1ncc2ccc(Oc3c(F)cc(C(F)(F)F)cc3Cl)cc21,CN(C)C=O,CC(=O)CC(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20140309193A1,COc1ccc(-n2c(C#N)c(OCc3ccccc3)c(OCc3ccccc3)c2C#N)cc1>>COc1ccc(-n2c(C#N)c(O)c(O)c2C#N)cc1,[Pd],C1CCOC1,,,,val
US06586441B2,COc1cc(-c2nc(N)nc(S(C)(=O)=O)c2C#N)cc(OC)c1OC.SCc1ccccc1>>COc1cc(-c2nc(N)nc(SCc3ccccc3)c2C#N)cc(OC)c1OC,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20090143402A1,CCOC(=O)CC(C)=O.O=C(O)c1ccccc1Br>>CCOC(=O)C(C(C)=O)c1ccccc1C(=O)O,[Cu]Br,,,C1COCCO1,,val
US05750696,CN(C(=O)[C@H](Cc1ccccc1)NC(=O)N1CCCCC1)[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C[C@@H]1OCOC1(C)C.Cl>>CN(C(=O)[C@H](Cc1ccccc1)NC(=O)N1CCCCC1)[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C[C@@H]1OCOC1(C)C.Cl,,CCO,CCOC(C)=O,,,val
US20130303788A1,COc1ccc(CC(O)CO)cc1-c1ccc(OC2CCCCO2)cc1>>C=CCOc1ccc(-c2cc(CC(O)CO)ccc2OC)cc1,,CCCCCC,CCOC(C)=O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150087639A1,COC(=O)/C=C(/C)NC(C)=O.Nc1ccc(-n2cccc2)c(F)c1>>Cc1cc(=O)n(-c2ccc(-n3cccc3)c(F)c2)c(C)n1,,ClCCl,,C[Al](C)C,,val
US20110098297A1,CC#CC(=O)OCC.COCC(C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc2cc(C(N)=O)[nH]c12.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)CC1CN=C(c2cc3cc(Oc4ccc(S(C)(=O)=O)cc4)cc(OC(C)COC)c3[nH]2)S1,,C1CCOC1,,CCCCP(CCCC)CCCC,,val
US20080114022A1,CCS(=O)(=O)c1ccc(CBr)c(Cl)c1.COC(=O)Cc1c(C)[nH]c2ncccc12>>CCS(=O)(=O)c1ccc(Cn2c(C)c(CC(=O)OC)c3cccnc32)c(Cl)c1,,CN(C)C=O,,[H-].[Na+],,val
US20100305093A1,CI.CS(=O)(=O)c1ccc(C(=O)N2CCOc3ccc(-c4ccc5[nH]c(=S)[nH]c5c4)cc3C2)cc1>>CSc1nc2ccc(-c3ccc4c(c3)CN(C(=O)c3ccc(S(C)(=O)=O)cc3)CCO4)cc2[nH]1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US04352811,Fc1ccc2onc(C3CCNCC3)c2c1.O=c1[nH]c2ccccc2n1CCCCl>>O=c1[nH]c2ccccc2n1CCCN1CCC(c2noc3ccc(F)cc23)CC1,,CC(=O)CC(C)C,,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20030027832A1,O=C(Cl)CCCl.c1ccc2c(c1)CCN2>>O=C(CCCl)N1CCc2ccccc21,,C1CCOC1,,CCN(CC)CC,,val
US04002757,CNC1CCN(C2CCCCC2)C1.O=C(Cl)c1cc(Cl)nc2ccccc12>>CN(C(=O)c1cc(Cl)nc2ccccc12)C1CCN(C2CCCCC2)C1.Cl,,c1ccccc1,,,,val
US05387671,N#Cc1cccc(C(=O)O)c1>>NCc1cccc(C(=O)O)c1,[Pd],CO,,,,val
US20040086993A1,N#C[Cu].O=C(Cl)c1cccc(Cl)c1>>N#CC(=O)c1cccc(Cl)c1,,Cc1ccccc1,,CC#N,,val
US05244898,CCOC(=O)COC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccc(Cl)cc21>>Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(OCCO)c3cc(Cl)ccc32)cc1,,C1CCOC1,,Cl,[BH4-].[Li+],val
US20030207865A1,O=C(O)Cc1cccs1.OCC1(NC2CCCC2)CCCC1>>CC(=S)CC1(NC2CCCC2)CCCC1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04164407,Nc1cc(Cl)ccc1CBr.O=C(Cl)Cl>>O=C=Nc1cc(Cl)ccc1CBr,,c1ccccc1,,Br,,val
US04772600,NC(=O)Cn1c(-c2ccc(Cl)cc2)nc2cccnc21.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>NC(=S)Cn1c(-c2ccc(Cl)cc2)nc2cccnc21.O,,CC#N,,,,val
US20110201625A1,CN(CCN)C(=O)OC(C)(C)C.Nc1nc(N)c(C(=O)O)nc1Cl>>CN(CCNC(=O)c1nc(Cl)c(N)nc1N)C(=O)OC(C)(C)C,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US04713367,CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O>>CC(C)(C)OC(=O)NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O,,CN(C)C=O,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20110076292A1,CC(C)n1ncc(C#N)c1N.CCCC[Sn](CCCC)(CCCC)c1cn2c(n1)-c1ccc(C(=O)OC)cc1OCC2>>COC(=O)c1ccc2c(c1)OCCn1cc(-c3c(C#N)cnn3C(C)C)nc1-2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,Cc1ccccc1,,val
US20080081810A1,CC(C)(C)C=O.COC(=O)CCN>>COC(=O)CCNCC(C)(C)C,,CO,,[BH3-]C#N.[Na+],,val
US20070105943A1,CC(C)=CCBr.N#Cc1cccc(O)c1>>CC(C)=CCOc1cccc(C#N)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04714702,Cc1ccc(F)cc1NC(=O)c1cc([N+](=O)[O-])ccc1N.O=C(Cl)CF>>Cc1ccc(F)cc1NC(=O)c1cc([N+](=O)[O-])ccc1NC(=O)CF,,c1ccncc1,,,,val
US20100179147A1,Cc1ccc([N+](=O)[O-])c(N)c1.O=C(Cl)c1ccccc1>>Cc1ccc([N+](=O)[O-])c(NC(=O)c2ccccc2)c1,,ClCCl,,c1ccncc1,,val
US20160068529A1,FC1(F)CCNC1.O=Cc1cncc(Br)c1>>FC1(F)CCN(Cc2cncc(Br)c2)C1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100120798A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C1(CN)CCN(C(=O)OC(C)(C)C)CC1>>CCOC(=O)C1(CNC(=O)OC(C)(C)C)CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,,,val
US04238575,C=C(C)C(=O)Cl.CCCCCCCCSCCO>>C=C(C)C(=O)OCCSCCCCCCCC,,c1ccccc1,,c1ccncc1,,val
US20070054924A1,C=CC(N)=O.CCOC(=O)CC(=O)C(F)(F)C(F)(F)F>>CCOC(=O)C1=C(C(F)(F)C(F)(F)F)NC(=O)CC1,,Clc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110190263A1,CC(C)(C)OC(=O)N1CCC(CN)CC1.CS(=O)(=O)N1CCc2nc(C=O)ncc2C1>>CC(C)(C)OC(=O)N1CCC(CNCc2ncc3c(n2)CCN(S(C)(=O)=O)C3)CC1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040167176A1,CC(C)Cc1cc(-c2ccc(Cn3cncn3)cc2)c(S(N)(=O)=O)s1.CCCCOC(=O)Cl>>CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cncn2)cc1,CN(C)c1ccncc1,CCN(CC)CC,CCOC(C)=O,,,val
US20050233988A1,CCI.Oc1ccc2cc(Cc3cc(Br)ccc3Cl)sc2c1>>CCOc1ccc2cc(Cc3cc(Br)ccc3Cl)sc2c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04086238,C#CCNC(C=O)COC.CCCCCCc1nnc(N=C=O)s1>>C#CCN(C(=O)Nc1nnc(CCCCCC)s1)C(C=O)COC,,c1ccccc1,,,,val
US20070135461A1,C[Si](C)(C)CCOCn1ccc2c(-c3cnc(Br)s3)ncnc21>>Brc1ncc(-c2ncnc3[nH]ccc23)s1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100210680A1,CB1OB(C)OB(C)O1.C[C@]12CN(Cc3ccccc3)C[C@H]1c1ccc(Br)c(Cl)c1CO2>>Cc1ccc2c(c1Cl)CO[C@@]1(C)CN(Cc3ccccc3)C[C@@H]21,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20100179111A1,CNC.O=CCc1ccccc1>>CN(C)CCc1ccccc1,,CO,,[BH3-]C#N.[Na+],,val
US20150018363A1,Cn1c(C2CC2)nc2ccc(-n3ccc(O)cc3=O)cc21.OCc1ccc(Cl)cn1>>Cn1c(C2CC2)nc2ccc(-n3ccc(OCc4ccc(Cl)cn4)cc3=O)cc21,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20160039797A1,C#Cc1cc(Nc2nccc(Oc3ccc(N)c4ccccc34)n2)cc(C(=O)NCCOCCOCCOC)c1.CC(C)c1cc(NC(=O)Oc2ccccc2)n(C)n1>>C#Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)C)nn4C)c4ccccc34)n2)cc(C(=O)NCCOCCOCCOC)c1,,C1CCOC1,,,,val
US20120245094A1,COC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)OC(C)(C)C)C(C)C.O=C(O)C(F)(F)F>>COC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C.O=C(O)C(F)(F)F,,ClCCl,ClCCl,,,val
US20150361059A1,Cc1ccc(N)c(OC[C@H](NC(=O)OC(C)(C)C)C(=O)O)c1>>Cc1ccc2c(c1)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N2,,CCOC(C)=O,CN(C)C=O,CCN=C=NCCCN(C)C,,val
US20130303518A1,CCN(CC)CCN1CCCc2[nH]c(C=O)c(C)c2C1=O.O=C1Cc2cc(F)ccc2N1>>CCN(CC)CCN1CCCC2NC(/C=C3\C(=O)Nc4ccc(F)cc43)=C(C)C2C1=O,,CCO,,C1CCNCC1,,val
US20150239886A1,CC(C)(C)OC(=O)N1CCC=C(c2ccnc3nnc4c(ccn4S(=O)(=O)c4ccccc4)c23)C1>>CC(C)(C)OC(=O)N1CCC=C(c2ccnc3nnc4[nH]ccc4c23)C1,,CC(C)=O,,[Na+].[OH-],,val
US20130131018A1,CCOc1cccc(CNCC(OCC)OCC)c1O.COc1cc(C=O)cc(OC)c1Nc1ccccc1.Cl>>CCOc1ccc2c(Cc3cc(OC)c(Nc4ccccc4)c(OC)c3)cncc2c1O.Cl,,CCO,,CO,,val
US20100280019A1,CCCCc1noc(C)c1COc1ccc(C(=O)O)cn1.CN(C)N>>CCCCc1noc(C)c1COc1ccc(C(=O)NN(C)C)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20090156590A1,CCOC(=O)C(C)c1ccc(NC(=O)CCl)c(O)c1>>CCOC(=O)C(C)c1ccc2c(c1)OCC(=O)N2,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20140315949A1,CC(=O)OC(C)=O.CC(CCN)c1ccc(Br)cc1>>CC(=O)NCCC(C)c1ccc(Br)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20090264676A1,CCN=C=NCCCN(C)C.CC[C@H](CC[N+](=O)[O-])C(=O)O.CN(C)c1ccncc1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CC[C@H](CC[N+](=O)[O-])C(=O)N[C@@H](Cc1ccccc1)C(=O)OC,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20040152742A1,CCN(CC)CCN1CCc2cc([N+](=O)[O-])ccc21>>CCN(CC)CCN1CCc2cc(N)ccc21,[Ni],CO,,,,val
US20150164974A1,COC(=O)c1ccc(C(=O)Nc2ccc(C[C@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(=O)N3C[Si](C)(C)C[C@H]3C(=O)N[C@@H]3CCCc4ccccc43)cc2)cc1>>C[C@@H](C(=O)N[C@@H](Cc1ccc(NC(=O)c2ccc(C(=O)O)cc2)cc1)C(=O)N1C[Si](C)(C)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)N(C)C(=O)OC(C)(C)C,,CO,O,[Li+].[OH-],,val
US05166378,CCCCCCCCCCCCC(Oc1ccc([N+](=O)[O-])cc1)C(=O)NNC1=NN=C(C)CS1>>CCCCCCCCCCCCC(Oc1ccc([N+](=O)[O-])cc1)c1nnc2n1N=C(C)CS2,,O,,CC(=O)O,,val
US20100210694A1,CC(=O)Oc1ccccc1C(=O)O.O=C(OCCl)c1ccc(OCCCO[N+](=O)[O-])cc1>>CC(=O)Oc1ccccc1C(=O)OCOC(=O)c1ccc(OCCCO[N+](=O)[O-])cc1,,CN(C)C=O,O,CCN(CC)CC,,val
US20090281142A1,CCOC(=O)C(=O)c1csc(N)n1.O=C1CCC(=O)N1Br>>CCOC(=O)C(=O)c1nc(N)sc1Br,,CC(=O)O,,,,val
US20150336894A1,CO.O=[N+]([O-])c1cc[n+]([O-])cc1F>>COc1c[n+]([O-])ccc1[N+](=O)[O-],,CO,,C[O-].[Na+],,val
US05739345,Cn1c(COc2ccc(CC3SC(=O)N(C(c4ccccc4)(c4ccccc4)c4ccccc4)C3=O)cc2)nc2ccc(Cl)nc21>>Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccc(Cl)nc21,,O,,CC(=O)O,,val
US20110071170A1,Br.CNC(=O)Cc1cc2nn(Cc3ncc(C)c(OC)c3Cl)nc3c-2c1CSN=C3N>>Br.CNC(=O)Cc1cc2nn(Cc3ncc(C)c(OC)c3Cl)nc3c-2c1CSN=C3N,,CC#N,,CCO,,val
US20100210647A1,CC(=O)OC(C)=O.CCOc1ccc(N)cc1>>CCOc1ccc(NC(C)=O)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US03998879,CCC(C)C1CC(=O)CC(=O)C1.O=C=NS(=O)(=O)c1ccc(Cl)cc1>>CCC(C)C1CC(=O)C(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)C(=O)C1,,c1ccccc1,,,,val
US20140051676A1,FC(F)(F)COCC1CCNCC1.Nc1nc(Nc2ccccc2)nc(-c2noc(C(Cl)(Cl)Cl)n2)n1>>Nc1nc(Nc2ccccc2)nc(-c2noc(N3CCC(COCC(F)(F)F)CC3)n2)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20150158847A1,CCC(O)c1ccc(OC)nc1.O=S(Cl)Cl>>CCC(Cl)c1ccc(OC)nc1,,ClCCl,,,,val
US20040034251A1,CC(C)=O.COc1cc(OC)nc(S(C)(=O)=O)n1>>COc1cc(OC)nc(CC(C)=O)n1,,O,,C1CCOC1,[H-].[Na+],val
US20040167135A1,N#Cc1ncccc1F.[Cl-].[NH4+]>>Cl.N=C(N)c1ncccc1F,,CO,,CC(=O)O,[Na],val
US20160002175A1,Cc1cccc(-c2cc(NCC(C)(C)CNC(=O)OC(C)(C)C)nc(N)n2)c1C>>Cc1cccc(-c2cc(NCC(C)(C)CN)nc(N)n2)c1C,,O=C(O)C(F)(F)F,,,,val
US20060142278A1,CI.O=C1NCC2C(c3cc(F)ccc3F)=CC(c3ccccc3)N12>>CN1C[C@H]2C(c3cc(F)ccc3F)=C[C@@H](c3ccccc3)N2C1=O,,C1CCOC1,,[H-].[Na+],,val
US20090286778A1,COc1ccc(N)cc1CCc1cccc(NC(=O)OC(C)(C)C)c1.Clc1ncc(Cl)c(Cl)n1>>COc1ccc(Nc2nc(Cl)ncc2Cl)cc1CCc1cccc(NC(=O)OC(C)(C)C)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04906634,CCCCBr.OCC1CCCN1>>CCCCN1CCCC1CO,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20140206681A1,CCOC(=O)COCc1ccc(C(=O)OC)cn1>>COC(=O)[C@@H]1CC[C@@H]2COCC(=O)N2C1,,CC(=O)O,,[BH3-]C#N.[Na+],,val
US20120010247A1,CCI.OCc1ccc(O)c(Br)c1>>CCOc1ccc(CO)cc1Br,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US04775692,CCCCC(C)(C)C(=O)OC.COP(C)(=O)OC>>CCCCC(C)(C)C(=O)CP(=O)(OC)OC,,C1CCOC1,O,CC(=O)O,[Li]CCCC,val
US20030045537A1,COCC1COc2cc([N+](=O)[O-])c(C(=O)O)cc2O1>>COCC1COc2cc(N)c(C(=O)O)cc2O1,[Pd],CO,,,,val
US04766133,Cc1cnc(CS(=O)c2nc3ccc(C(F)(F)F)cc3[nH]2)c(C)c1.Cl.NCCS>>Cc1cc(C)c(CSSCCN)[n+](-c2nc3ccc(C(F)(F)F)cc3[nH]2)c1.[Cl-],,C1CCOC1,,,,val
US20120277224A1,COC(=O)CC(=O)c1ccc(OC)cc1>>COC(=O)CC(=O)c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,,val
US20120034270A1,COc1cc(CCc2ccc3[nH]ccc3c2)cc(OC)c1OC>>COc1cc(CCc2ccc3c(c2)CCN3)cc(OC)c1OC,,C1CCOC1,,[BH3-]C#N.[Na+],,val
US20110224262A1,CCC(=O)C(=CN(C)C)c1ccccc1.NN>>CCc1[nH]ncc1-c1ccccc1,,CCO,,O,,val
US20140066424A1,Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)n[nH]1.ClCc1ccnc(Cl)n1>>Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1ccnc(Cl)n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090233915A1,C[Si](C)(C)C#Cc1ccc(Nc2c(C(=O)NOCCO)cc(COCCO)c(F)c2F)c(F)c1>>C#Cc1ccc(Nc2c(C(=O)NOCCO)cc(COCCO)c(F)c2F)c(F)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05091533,COc1ccc2oc(CO)cc2c1>>COc1ccc2oc(C=O)cc2c1,O=[Mn]=O,,,,,val
US20080221148A1,CC(C)[Si](C(C)C)(C(C)C)n1cc(I)c2cccnc21.COc1cc(C=O)c(Cl)cc1OCc1ccc(Cl)cc1F>>COc1cc(C(O)c2cn([Si](C(C)C)(C(C)C)C(C)C)c3ncccc23)c(Cl)cc1OCc1ccc(Cl)cc1F,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20110288090A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4ccnc(COCc5ccnc(F)c5)c4cc3-c3ccccc3)cc2)CCC1.O>>NC1(c2ccc(-c3nc4ccnc(COCc5cc[nH]c(=O)c5)c4cc3-c3ccccc3)cc2)CCC1,,CCOC(C)=O,c1ccncc1,,,val
US20120165346A1,CI.Cc1cc([C@]2(c3cccc(Br)c3)N=C(N)c3c(F)cccc32)c[nH]c1=O>>Cc1cc([C@]2(c3cccc(Br)c3)N=C(N)c3c(F)cccc32)cn(C)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20090253689A1,CCOC(=O)c1cnc2cc(CNC(=O)OC(C)(C)C)c(Br)cn12.OB(O)c1ccc(Cl)cc1Cl>>CCOC(=O)c1cnc2cc(CNC(=O)OC(C)(C)C)c(-c3ccc(Cl)cc3Cl)cn12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20060079680A1,COc1ccc2c(CC(=O)c3ccccn3)ccnc2c1.NN>>COc1ccc2c(CC(=NN)c3ccccn3)ccnc2c1,,CCO,,Cl,O,val
US20150376136A1,CC1(C2CCCC2)NC(=O)N(CC(=O)c2ccccc2)C1=O.CI>>CN1C(=O)N(CC(=O)c2ccccc2)C(=O)C1(C)C1CCCC1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110230483A1,CCO.COC(=O)c1nc(O)c(C(F)(F)F)cc1-n1c(C)ccc1C>>CCOc1nc(C(=O)OC)c(-n2c(C)ccc2C)cc1C(F)(F)F,,C1COCCO1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100093757A1,Cc1ccc(NC(=O)[C@H](COC2CCC2)O[Si](C)(C)C(C)(C)C)nc1>>Cc1ccc(NC(=O)[C@@H](O)COC2CCC2)nc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140080788A1,CCOC(=O)c1ccc(Br)cn1>>OCc1ccc(Br)cn1,,CO,,[BH4-].[Na+],,val
US06087380,COC(=O)CN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C)c1ccccn1.O=C(Cl)OC1CCCCC1>>COC(=O)CN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)NC(=O)OC3CCCCC3)cc1)n2C)c1ccccn1,,CCO,ClCCl,Cl,,val
US20050153987A1,O=C1CCC(=O)N1Br.O=C1Cc2ccc(Br)cc2N1>>O=C1Cc2cc(Br)c(Br)cc2N1,,CC(=O)O,,,,val
US20050203081A1,COC(=O)COc1c(C(=O)OC)sc2cc(N)ccc12.O=C(Cl)c1ccccc1>>COC(=O)COc1c(C(=O)OC)sc2cc(NC(=O)c3ccccc3)ccc12,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20020107278A1,CO.COC(=O)C(C(=O)OC)c1[nH]c2cc(F)ccc2c1CCN=[N+]=[N-]>>COC(=O)C(C)(C(=O)OC)c1[nH]c2cc(F)ccc2c1CCN=[N+]=[N-],,CO,,C[O-].[Na+],,val
US20090018103A1,CCOCCCC[C@@H](c1ccccc1)[C@@H]1CCCN(C(=O)N[C@@H](CC2CCCCC2)CN(C)C(=O)OC(C)(C)C)C1>>CCOCCCC[C@@H](c1ccccc1)[C@@H]1CCCN(C(=O)N[C@H](CNC)CC2CCCCC2)C1,,C1COCCO1,Cl,,,val
US20100311966A1,CCc1[nH]c(C(=O)O)nc1Cl.COC(=O)c1coc(-c2ccc(N)c(C)c2)n1>>CCc1[nH]c(C(=O)Nc2ccc(-c3nc(C(=O)OC)co3)cc2C)nc1Cl,,c1ccncc1,,O=S(Cl)Cl,,val
US20120058984A1,Cl[Mg]Cc1ccccc1.Fc1cc(F)nc(F)n1>>Fc1cc(Cc2ccccc2)nc(F)n1,,C1CCOC1,,,,val
US20040029874A1,CC(C)(C)OC(=O)N1CCNCC1.Nc1ccc(Cl)cc1Br.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1CCN(C(=O)Nc2ccc(Cl)cc2Br)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060100229A1,CCCn1nc2c(N)nc3ccccc3c2c1CCCCN1C(=O)c2ccccc2C1=O>>CCCn1nc2c(N)nc3ccccc3c2c1CCCCN,,CCO,,NN,O,val
US20030073849A1,CN(C)C=Cc1cc(F)c(F)cc1[N+](=O)[O-]>>Fc1cc2cc[nH]c2cc1F,[Pd],CO,,,,val
US07291615B2,C=O.CC(C)N[C@H]1CC[C@H](NC(=O)OCc2ccccc2)[C@H](CS(=O)(=O)c2ccc(Br)cc2)C1>>CC(C)N(C)[C@@H]1CC[C@H](NC(=O)OCc2ccccc2)[C@H](CS(=O)(=O)c2ccc(Br)cc2)C1,,CO,O,[BH3-]C#N.[Na+],,val
US20140179676A1,CCn1nc(-c2ccccn2)c2c1NC(C)CSC2c1ccc(C#CCO)cc1C>>CCn1nc(-c2ccccn2)c2c1NC(C)CSC2c1ccc(CCCO)cc1C,[Pd],C1CCOC1,,CO,,val
US20080058320A1,Cc1cc(O)cc(=O)[nH]1.O=P(Br)(Br)Br>>Cc1cc(Br)cc(=O)[nH]1,,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)O)c2)=C(C)C1=O.Nc1ccccc1[N+](=O)[O-]>>COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccccc3[N+](=O)[O-])c2)=C(C)C1=O,,ClCCl,,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US05714438,Cc1ncncc1C(=O)C=CN(C)C.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1ncncc1C(=O)C(=CN(C)C)C(=O)C(F)(F)F,,ClCCl,,,,val
US20130040930A1,Cc1ccc(S(=O)(=O)N2CCN(c3cnc(C)cc3C)CC2)cc1>>Cc1cc(C)c(N2CCNCC2)cn1,,CC(=O)O,,Br,[Na+].[OH-],val
US03952001,C=CCN(CC)C(=O)Cl.CCS(=O)(=O)c1nc[nH]n1>>C=CCN(CC)C(=O)n1cnc(S(=O)(=O)CC)n1,,C1CCOC1,,CCN(CC)CC,,val
US20090325964A1,BrCC1CC1.COC(=O)c1ccc(O)c(I)c1>>COC(=O)c1ccc(OCC2CC2)c(I)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050059722A1,CC(C)(C)OC(=O)n1nc(I)c2cc(NS(=O)(=O)c3ccccc3S(C)(=O)=O)ccc21.OB(O)c1cccc2ccccc12>>CS(=O)(=O)c1ccccc1S(=O)(=O)Nc1ccc2[nH]nc(-c3cccc4ccccc34)c2c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20030078432A1,BrBr.CC(C)n1nnc2ccc(C(=O)Cc3ccc(F)cc3)cc21>>CC(C)n1nnc2ccc(C(=O)C(Br)c3ccc(F)cc3)cc21,,CC(=O)O,,,,val
US20140288326A1,C=C(C)C1CCCCC1=O.CC=NOCC>>CCON1C(=O)CCCCC=C(C)CC1C,,ClCCCl,,Cl[Sn](Cl)(Cl)Cl,,val
US04391818,CCC(C(=O)O)c1ccc([N+](=O)[O-])cc1>>CCC(CO)c1ccc([N+](=O)[O-])cc1,,C1CCOC1,,CO,,val
US20050043335A1,Cc1ccc(Br)cc1[N+](=O)[O-].O=[Mn](=O)(=O)[O-]>>O=C(O)c1ccc(Br)cc1[N+](=O)[O-],,c1ccncc1,,O,,val
US20020061996A1,CCOc1cc(C=O)ccc1O.COC(=O)C=C=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CCOc1cc(/C=C/C(=O)OC)ccc1O,,Cc1ccccc1,,,,val
US20110039855A1,CC(C)OC(=O)N[C@H]1Cc2c(n(C[C@@H]3[C@@H](O)CCN3C(=O)OC(C)(C)C)c3ccc(C#N)cc23)C1.O=C(O)CCl>>CC(C)OC(=O)N[C@H]1Cc2c(n(C[C@@H]3[C@H](OC(=O)CCl)CCN3C(=O)OC(C)(C)C)c3ccc(C#N)cc23)C1,,C1CCOC1,CCOC(C)=O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05506190,CC1CCC(Oc2cc(N3C(=O)C4=C(CCCC4)C3=O)c(F)cc2Cl)C1.CCCCCCN>>CCCCCCNC(=O)C1=C(C(=O)Nc2cc(OC3CCC(C)C3)c(Cl)cc2F)CCCC1,,c1ccccc1,,CCN(CC)CC,,val
US20100168430A1,ClCOCc1ccccc1.Clc1ccnc2[nH]ccc12>>Clc1ccnc2c1ccn2COCc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20140051701A1,CCn1c(N2CCOCC2)c(C(N)=O)c(=O)c2cc([N+](=O)[O-])cnc21>>CCn1c(N2CCOCC2)c(C(N)=O)c(=O)c2cc(N)cnc21,[Ni],CCO,CN(C)C=O,,,val
US20080004251A1,COC(=O)CCc1ccc(O)cc1.O=S(=O)(Cl)Cl>>COC(=O)CCc1cc(Cl)c(O)c(Cl)c1,,CCOCC,,ClCCl,,val
US20060223843A1,CC(C)O.Cc1ccc2ncc(C#N)c(Cl)c2n1>>Cc1ccc2ncc(C#N)c(OC(C)C)c2n1,,C1CCOC1,,,,val
US20090163511A1,CI.COC(=O)c1ccc2[nH]c3c(c2c1)CN(C(=O)OC(C)(C)C)CC3>>COC(=O)c1ccc2c(c1)c1c(n2C)CCN(C(=O)OC(C)(C)C)C1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20050096336A1,COC(=O)Oc1cc(O)c2ccccc2c1.C[Si](C)(C)CCOCCl>>COC(=O)Oc1cc(OCOCC[Si](C)(C)C)c2ccccc2c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160096834A1,CC(=O)OCc1c(-c2ccnc3[nH]c(-c4cnn(C)c4)nc23)cc(F)cc1N1CCn2c(cc3c2CC(C)(C)C3)C1=O>>Cn1cc(-c2nc3c(-c4cc(F)cc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)ccnc3[nH]2)cn1,,C1CCOC1,O,[Na+].[OH-],,val
US20120128686A1,CC(C)(C)OC(=O)N1CCc2c(sc3ncnc(Nc4ccc(F)cc4OC4CCOCC4)c23)C1>>Fc1ccc(Nc2ncnc3sc4c(c23)CCNC4)c(OC2CCOCC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070037807A1,Cc1ccc(-c2c(CN)c(CC(C)(C)C)nc(C)c2C(=O)O)cc1.O=C(O)/C=C\C(=O)O>>Cc1ccc(-c2c(CN)c(CC(C)(C)C)nc(C)c2C(=O)O)cc1.O=C(O)/C=C\C(=O)O,,CC#N,,O,,val
US20160152609A1,COC(=O)c1cc2c(cc1OC)CCc1c(C(=O)N(C)C(C)(C)C)nc(-c3cccs3)n1-2.NN>>COc1cc2c(cc1C(=O)NN)-n1c(-c3cccs3)nc(C(=O)N(C)C(C)(C)C)c1CC2,,CC(C)O,,O,,val
US20100331378A1,CC(C)(C)[SiH2]OC(C)(C)c1nc(CO)co1.CS(=O)(=O)Cl>>CC(C)(C)[SiH2]OC(C)(C)c1nc(COS(C)(=O)=O)co1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,N#N,val
US20030203941A1,C[Si](C)(C)N=C=O.Nc1ccc(CCOCc2ccccc2-c2ccccc2)cc1>>NC(=O)Nc1ccc(CCOCc2ccccc2-c2ccccc2)cc1,,CN(C)C=O,,O,,val
US04806141,COC(Cl)Cl.Cc1cc(C)cc(O)c1>>Cc1cc(C)c(C=O)c(O)c1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US05017705,C=CC#N.Cl.O=C(Oc1ccccc1)C(Cl)(Cl)Cl>>N#CC(Cl)CC(Cl)(Cl)C(=O)Oc1ccccc1,[Cu],O=S1(=O)CCCC1,,c1ccncc1,,val
US04226878,N#CCCc1ccc(Br)cc1.c1c[nH]cn1>>N#CCCc1ccc(-n2ccnc2)cc1,,O=[N+]([O-])c1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US04571345,CC1CCCC(C)C1=O.C[Mg]Br>>CC1CCCC(C)C1(C)O,,CCOCC,,,,val
US20050101644A1,CC(C)(C)OC(=O)NC1CCN(Cc2cc(Br)ccc2OCc2ccc(Cl)cc2)CC1.CCI>>CCN(C(=O)OC(C)(C)C)C1CCN(Cc2cc(Br)ccc2OCc2ccc(Cl)cc2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US05602277,COC(=O)c1ccc([N+](=O)[O-])c(OCCO)c1>>COC(=O)c1ccc(N)c(OCCO)c1,O=[Pt],CCO,,CCCCCC,CCOC(C)=O,val
US06492384B1,Cc1nc(-c2cccc(Cn3c(C(C)C)nc4cc[nH]c(=O)c43)c2)no1.N#Cc1cccc(B(O)O)c1>>Cc1nc(-c2cccc(Cn3c(C(C)C)nc4ccn(-c5cccc(C#N)c5)c(=O)c43)c2)no1,,ClCCl,,,,val
US20140051676A1,COC(=O)c1ccc(OCCOCC(F)(F)F)nc1>>O=C(O)c1ccc(OCCOCC(F)(F)F)nc1,,CO,,[Na+].[OH-],,val
US20100152213A1,CI.O=c1c2cc(Br)ccc2[nH]c(=S)n1-c1ccccc1Br>>CSc1nc2ccc(Br)cc2c(=O)n1-c1ccccc1Br,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130267493A1,N#Cc1ccc2c(c1)NCC2.O=C1CCC(=O)N1Br>>N#Cc1cc2c(cc1Br)CCN2,,CC#N,,O=C([O-])O.[Na+],,val
US20120142710A1,CS(=O)(=O)Cl.OCc1nnc(-c2ccccn2)s1>>CS(=O)(=O)OCc1nnc(-c2ccccn2)s1,,ClCCl,,CCN(CC)CC,,val
US20150218096A1,CI.COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(N)ccc23)c(F)c1>>CNc1ccc2c(-c3ccc(C(=O)OC)cc3F)nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1,,CN(C)C=O,,,,val
US20080009530A1,CCCCCS(=O)(=O)NC(=O)/C=C/c1ccc(OCCOC)cc1OC1CCN(C(=O)OC(C)(C)C)CC1.Cl>>CCCCCS(=O)(=O)NC(=O)/C=C/c1ccc(OCCOC)cc1OC1CCNCC1.Cl,,CCOC(C)=O,,,,val
US20040152743A1,CC(=O)Nc1ccc(-c2noc(=O)[nH]2)cc1OC(F)(F)F.Cl>>Cl.Nc1ccc(-c2noc(=O)[nH]2)cc1OC(F)(F)F,,C1COCCO1,,CO,,val
US20010056123A1,CCOC(=O)C1CCNCC1.Clc1ccc(Cl)nn1>>CCOC(=O)C1CCN(c2ccc(Cl)nn2)CC1,,CN(C)C=O,,CCN(CC)CC,CCOC(C)=O,val
US06191124B1,CCOC(=O)c1cnc2sc3c(n12)CCC3>>OCc1cnc2sc3c(n12)CCC3,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160009704A1,NCc1cccc(OC(F)(F)F)c1.O=C(Cc1ccccn1)Nc1cn(CC(F)CCn2cc(C(=O)O)nn2)nn1>>O=C(Cc1ccccn1)Nc1cn(CC(F)CCn2cc(C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)nn1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05994368,COC(=O)c1nc2ccc(CO)cc2cc1C>>COC(=O)c1nc2ccc(C=O)cc2cc1C,,O,,CCN(CC)CC,ClCCl,val
US20130029964A1,O=[N+]([O-])O.c1ccn2nccc2c1>>O=[N+]([O-])c1cnn2ccccc12,,CCOCC,,O=S(=O)(O)O,,val
US06335459B1,COc1cccc(C(=O)O)c1C(C)C>>CC(C)c1c(O)cccc1C(=O)O,,ClCCl,,BrB(Br)Br,,val
US20110105473A1,CN(CCN)CCN.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CN(CCN)CCNS(=O)(=O)c1ccccc1[N+](=O)[O-],,ClCCl,,,,val
US08211916B2,BrCc1ccccc1.c1ccc(C(OCCc2ccncc2)c2ccccc2)cc1>>C1=C(CCOC(c2ccccc2)c2ccccc2)CCN(Cc2ccccc2)C1,,CC#N,,[BH4-].[Na+],,val
US20100076026A1,COC(=O)c1cccc(N=C=O)c1C.Clc1ccc(-n2nc3ccccc3c2NC2CCCCC2)cc1>>COC(=O)c1cccc(NC(=O)N(c2c3ccccc3nn2-c2ccc(Cl)cc2)C2CCCCC2)c1C,,ClCCCl,,CCN(CC)CC,,val
US20080275066A1,CI.S=C=S.c1c[nH]cn1>>CSC(=S)n1ccnc1,,C1CCOC1,O,[H-].[Na+],,val
US20070054935A1,CCOC(=O)c1cnc2cc(C(F)(F)F)ccc2c1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)c1cnc2cc(C(F)(F)F)ccc2c1OS(=O)(=O)C(F)(F)F,,CCOC(C)=O,,ClCCl,c1ccncc1,val
US20090209476A1,O=Cc1ccc(-c2cnc(Cl)nc2)cc1.OB(O)c1ccc(OC(F)(F)F)cc1>>O=Cc1ccc(-c2cnc(-c3ccc(OC(F)(F)F)cc3)nc2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US05298586,CI.Cc1nc(C)n(C)c1C>>Cc1c(C)[n+](C)c(C)n1C.[I-],,ClCCl,,,,val
US20150175599A1,COC(=O)C(=O)c1c(C)n(Cc2ccc(Cl)cc2)c2cc(OC)ccc12>>COc1ccc2c(C(=O)C(=O)O)c(C)n(Cc3ccc(Cl)cc3)c2c1,,CC#N,O,Cl,[Na+].[OH-],val
US20110183958A1,CCOC(=O)c1cnc(N2CC(Oc3cc(F)ccc3Br)C2)nc1>>O=C(O)c1cnc(N2CC(Oc3cc(F)ccc3Br)C2)nc1,,CO,,C1CCOC1,[Li+].[OH-],val
US20050176767A1,COC(=O)c1nc(-c2ccco2)cc(OC)c1OCc1ccccc1>>COC(=O)c1nc(C2CCCO2)cc(OC)c1O,[Pd],CCOC(C)=O,CO,CC(=O)O,,val
US20150105373A1,COCC(NC(=O)N1CC(=O)N(COCC[Si](C)(C)C)c2cc(OC)cnc21)c1ccc(OC(F)(F)F)c(F)c1>>COCC(NC(=O)N1CC(=O)Nc2cc(OC)cnc21)c1ccc(OC(F)(F)F)c(F)c1,,O,,O=C(O)C(F)(F)F,,val
US20130190322A1,CC(=CBr)c1ccc(C(=O)N(C)C)cc1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>C/C(=C/n1c2c(c3cc(C)ccc31)CN(C)CC2)c1cccc(C(=O)N(C)C)c1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20060004012A1,Cc1ccccc1CS.O=Cc1ccc(F)cc1>>Cc1ccccc1CSc1ccc(C=O)cc1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20030220324A1,CC(C)(C)OC(=O)N1Cc2ccccc2C[C@H]1C(=O)O.CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccn2)CC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CI.CN(C)C=O.Cl.On1nnc2cccnc21>>CC(C)(C)OC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccn2)CC1.O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccn2)CC1)[C@@H]1Cc2ccccc2CN1,,CCOC(C)=O,CN(C)C=O,,,val
US04816470,CC(C)NS(=O)(=O)Cc1ccc([N+](=O)[O-])cc1>>CC(C)NS(=O)(=O)Cc1ccc(N)cc1,,CCO,,,,val
US20050256158A1,CC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2ccc(O)cc2)c2ccccc21.COC(=O)[C@@H]1CCC[C@H]1CO>>COC(=O)C1CCCC1COc1ccc(C(=O)N2c3ccccc3[C@H](N(C(C)=O)c3ccc(Cl)cc3)C[C@@H]2C)cc1,,Cc1ccccc1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100279936A1,C#CCCCCl.C[C@@H](N)c1cccc2ccccc12>>C#CCCCN[C@H](C)c1cccc2ccccc12,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20070299258A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(CCn2c(Sc3nc4cccc(Cl)c4s3)nc3c(N)ncnc32)CC1.O=C(O)C(F)(F)F>>C[C@H](N)C(=O)N1CCC(CCn2c(Sc3nc4cccc(Cl)c4s3)nc3c(N)ncnc32)CC1.O=C([O-])C(F)(F)F,,ClCCl,,,,val
US20030073731A1,COc1cc2cc(C(=O)Nc3cc(NC(=O)OCc4ccccc4)c4ccccc4c3CCO)[nH]c2c(OC)c1OC>>COc1cc2cc(C(=O)Nc3cc(N)c4ccccc4c3CCO)[nH]c2c(OC)c1OC,[Pd],C1CCOC1,,,,val
US20060019957A1,O=C1c2ccccc2C(=O)N1Cc1nnc[nH]c1=O>>NCc1nnc[nH]c1=O,,CCO,ClCCl,NN,,val
US20110021494A1,CCOC(=O)c1cc2c([nH]1)CCN(C(=O)OC(C)(C)C)C2.CI>>CCOC(=O)c1cc2c(n1C)CCN(C(=O)OC(C)(C)C)C2,,C1CCOC1,,[H-].[Na+],,val
US20140206663A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.C[C@@H]1C(=O)NN=C2COc3cc(-c4ccccc4F)c(Br)cc3N21>>C[C@@H]1C(=O)NN=C2COc3cc(-c4ccccc4F)c(C4=CCN(C(=O)OC(C)(C)C)CC4)cc3N21,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20040259917A1,Brc1cn(-c2ccccn2)cn1.CCB(CC)c1cccnc1>>c1ccc(-n2cnc(-c3cccnc3)c2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20150023913A1,CCOC(=O)C1(CO)CC=CCO1.O=C(Cl)c1ccccc1>>CCOC(=O)C1(COC(=O)c2ccccc2)CC=CCO1,,ClCCl,,,,val
US20150368265A1,CNC(=O)c1c(-c2cccnc2OC)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc4c(n3)-c3cc5c(F)cccc5n3CO4)cc12>>CNC(=O)c1c(-c2cccnc2O)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc4c(n3)-c3cc5c(F)cccc5n3CO4)cc12,,CC(=O)O,,[I-].[Na+],,val
US06262059B1,CCOC(=O)C1CCNCC1.Clc1ccc2nc(Cl)cc(NCc3ccc4c(c3)OCO4)c2c1>>CCOC(=O)C1CCN(c2cc(NCc3ccc4c(c3)OCO4)c3cc(Cl)ccc3n2)CC1,,O,,CN1CCCC1=O,,val
US20100004292A1,CC(C)(C)[Si](C)(C)OCCNc1ccc(NC(=O)c2ccc(F)cc2NC(=O)c2ccc(Cl)s2)cc1.N#CBr>>CC(C)(C)[Si](C)(C)OCCN(C#N)c1ccc(NC(=O)c2ccc(F)cc2NC(=O)c2ccc(Cl)s2)cc1,,CCOCC,,O=C([O-])O.[Na+],,val
US05409928,CCOC([O-])[O-].Cc1cccc(Cc2ccc(-c3cnn(C(N)=O)c3N)cc2)c1>>Cc1cccc(Cc2ccc(-c3cnn4c(O)ncnc34)cc2)c1,,CCOC(C)=O,,CN(C)C=O,,val
US20130102576A1,CC(C)(C)OC(=O)CBr.O=C1Nc2cc(F)ccc2C1=O>>CC(C)(C)OC(=O)CN1C(=O)C(=O)c2ccc(F)cc21,,CN(C)C=O,,[H-].[Na+],,val
US04115575,CC(C)N.COc1ncccc1OCC(O)COS(C)(=O)=O>>COc1ncccc1OCC(O)CNC(C)C,,CC(C)O,,,,val
US05162391,C=C(C)C(=O)Cl.CNCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C>>C=C(C)C(=O)N(C)CCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C,,CCOCC,,O,c1ccncc1,val
US20060084649A9,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.CC(C)C(=O)Nc1cc(Br)c(F)cc1F>>CC(C)C(=O)Nc1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)c(F)cc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150197524A1,C1CCNC1.CC(C)Cn1c(=O)n(C)c(=O)c2c(Nc3ccccc3)n(Cc3ccc(CBr)cc3)nc21>>CC(C)Cn1c(=O)n(C)c(=O)c2c(Nc3ccccc3)n(Cc3ccc(CN4CCCC4)cc3)nc21,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20150119373A1,CC1(C)[C@H](C(=O)OCc2ccccc2)C[C@@H]1C(=O)OC(=O)c1c(Cl)cc(Cl)cc1Cl.CC1([C@@H]2CC[C@]3(C(=O)N4CCOCC4)CC[C@]4(C)[C@H](CC[C@@H]5[C@@]6(C)CC[C@H](O)C(C)(C)[C@@H]6CC[C@]54C)[C@@H]23)CC1>>CC1(C)[C@H](C(=O)OCc2ccccc2)C[C@@H]1C(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C5(C)CC5)CC[C@]4(C(=O)N4CCOCC4)CC[C@]23C)C1(C)C,CN(C)c1ccncc1,Cc1ccccc1,,,,val
US20130296354A1,CC(C)C(=O)Cl.CS(=O)(=O)N1CC=C(c2cc3c(cn2)OC2(C3)CC3(CCN(C(=N)NO)CC3)C2)CC1>>CC(C)c1nc(N2CCC3(CC2)CC2(Cc4cc(C5=CCN(S(C)(=O)=O)CC5)ncc4O2)C3)no1,,C1CCOC1,CO,CCN(CC)CC,,val
US05192781,CC(=O)OC(C)=O.CCCc1nc(N)sc1Cc1ccc([N+](=O)[O-])cc1>>CCCc1nc(NC(C)=O)sc1Cc1ccc([N+](=O)[O-])cc1,CN(C)c1ccncc1,,,,,val
US20160024103A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(CS(C)(=O)=O)c(O)cc12.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(CS(C)(=O)=O)c(OS(=O)(=O)C(F)(F)F)cc12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020007083A1,FC(F)(Br)C(F)(F)Oc1cccc(OC(F)(F)C(F)(F)Br)c1.O=S(=O)(O)Cl>>O=S(=O)(Cl)c1ccc(OC(F)(F)C(F)(F)Br)cc1OC(F)(F)C(F)(F)Br,,ClC(Cl)Cl,,Cl,,val
US04448772,CCN(CP(=O)(CCCCc1ccccc1)OCOC(=O)C(C)(C)C)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1>>CCN(CP(=O)(CCCCc1ccccc1)OCOC(=O)C(C)(C)C)C(=O)N1CCC[C@H]1C(=O)O,[Pd],CO,,,,val
US03935218,Br.OC1(c2ccccc2)c2ccccc2C2=NCCN21>>Br.O=C(c1ccccc1)c1ccccc1C1=NCCN1,,CCO,,,,val
US05656645,CI.O=c1[nH]cc([N+](=O)[O-])c(=O)[nH]1>>Cn1cc([N+](=O)[O-])c(=O)[nH]c1=O,,CN(C)C=O,O,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20100273786A1,CCOC(=O)c1nc(C(F)(F)F)n2c1CN(C(=O)C[C@@H](Cc1cc(F)c(F)cc1F)NC(=O)OC(C)(C)C)CC2.Cl>>CCOC(=O)c1nc(C(F)(F)F)n2c1CN(C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)CC2.Cl,,CCOC(C)=O,,,,val
US20060004030A1,O=Cc1c(Cl)nc(Cl)nc1Cl.O=S(=O)(Cl)Cl>>O=C(Cl)c1c(Cl)nc(Cl)nc1Cl,,CC(Cl)Cl,,,,val
US04762881,CC(C)(C)OC(=O)ON=C(C#N)c1ccccc1.N[C@@H](Cc1cccc(C(=O)c2ccccc2)c1)C(=O)O>>CC(C)(C)OC(=O)N[C@@H](Cc1cccc(C(=O)c2ccccc2)c1)C(=O)O,,CC(C)=O,O,CCN(CC)CC,,val
US20090298807A1,CC(C)(C)OC(=O)N1CCC(O)(CNC(=O)C(F)(F)Br)CC1>>CC(C)(C)OC(=O)N1CCC2(CC1)CNC(=O)C(F)(F)O2,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20100144695A1,CN(C)Cc1nccs1.O=C1CCC2(CC1)OCCO2>>CN(C)Cc1ncc(C2(O)CCC3(CC2)OCCO3)s1,,CCOCC,,,,val
US20120214762A1,Cc1nc2ccc(C#CC(O)C3CC(O[Si](C)(C)C(C)(C)C)C3)cc2n1-c1ncnc(N)n1>>Cc1nc2ccc(C#CC(O)C3CC(O)C3)cc2n1-c1ncnc(N)n1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110230486A1,COc1ccc(S(=O)(=O)c2cc(C)c(C(=O)CBr)c(C)c2)cc1.NC(N)=S>>COc1ccc(S(=O)(=O)c2cc(C)c(-c3csc(N)n3)c(C)c2)cc1,,CCO,,,,val
US20090325902A1,CCNC(=O)Nc1cc(Br)c(I)cn1.CCOC(=O)c1cncc(B2OC(C)(C)C(C)(C)O2)c1>>CCNC(=O)Nc1cc(Br)c(-c2cncc(C(=O)OCC)c2)cn1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20030092720A1,CC(=O)Nc1cc(C(=O)Nc2nc(C(C)(C)C)cs2)ccn1>>CC(C)(C)c1csc(NC(=O)c2ccnc(N)c2)n1,,CCO,,Cl,,val
US20080070903A1,CC1=C(C(=O)OCCC#N)C(c2cccc(Cl)c2)C(C(=O)OCCCN2CCC(=C3c4ccccc4C=Cc4ccccc43)CC2)=C(C)N1>>CC1=C(C(=O)O)C(c2cccc(Cl)c2)C(C(=O)OCCCN2CCC(=C3c4ccccc4C=Cc4ccccc43)CC2)=C(C)N1,,CO,,Cl,[Na+].[OH-],val
US20150094297A1,CC1(C(N)=S)CCOCC1.CCOC(=O)C(=O)CBr>>CCOC(=O)c1csc(C2(C)CCOCC2)n1,,CC(C)O,,,,val
US20070112068A1,FCCCBr.N#CC(C#N)CC(F)(F)C(F)(F)C(F)(F)C(F)F>>N#CC(C#N)(CCCF)CC(F)(F)C(F)(F)C(F)(F)C(F)F,,COCCOC,,Cl,O=C([O-])[O-].[K+].[K+],val
US04012433,O=C(Nc1cccc(Cl)c1)OCC#CCO.O=S(Cl)Cl>>O=C(Nc1cccc(Cl)c1)OC#CCl,,ClCCCl,,,,val
US20100249146A1,CNCCN(C)C.O=S(=O)(Cl)c1cnc(Cl)c(Cl)c1>>CN(C)CCN(C)S(=O)(=O)c1cnc(Cl)c(Cl)c1,,O,,C1CCOC1,CCN(CC)CC,val
US20050171093A1,COC(=O)c1cc(C)c2nc(C)c(C)nc2c1>>Cc1nc2cc(CO)cc(C)c2nc1C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150353539A1,COC(=O)c1cc2cc(CN)cnc2[nH]1.Cc1ccc([N+](=O)[O-])cc1C(=O)O>>COC(=O)c1cc2cc(CNC(=O)c3cc([N+](=O)[O-])ccc3C)cnc2[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04643759,Cc1nc2c(S(=O)(=O)Cl)cccc2s1.N>>Cc1nc2c(S(N)(=O)=O)cccc2s1,,C1CCOC1,,,,val
US20120071616A1,Cc1cc(C)c(N)c(C)c1.Cc1ccccc1NCc1ccc2ccccc2c1-c1cccc(C=O)n1>>Cc1cc(C)c(N=Cc2cccc(-c3c(CNc4ccccc4C)ccc4ccccc34)n2)c(C)c1,,CCO,,,,val
US04261999,OCC1Cc2ccsc2CN1C(=S)Nc1cccnc1>>c1cncc(N=C2SCC3Cc4ccsc4CN23)c1,,Cl,,C,,val
US20060257987A1,CCOC(=O)CSc1ccc(OCC[C@H](C)O)cc1C.CS(=O)(=O)Cl>>CCOC(=O)CSc1ccc(OCC[C@H](C)OS(C)(=O)=O)cc1C,,ClCCl,,CCN(CC)CC,,val
US20090137595A1,Cc1cn(C)nc1C(=O)O.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)ccc1F>>Cc1cn(C)nc1C(=O)Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)ccc1F,CN(C)C=O,C1CCOC1,CC(=O)N(C)C,O=S(Cl)Cl,O=C([O-])O.[Na+],val
US20080275041A1,CCCN(CCC)CCN1CCN(S(=O)(=O)c2ccc(Cl)nc2)CC1.N#Cc1ccc2c(c1)NC(=O)C2>>CCCN(CCC)CCN1CCN(S(=O)(=O)c2ccc(-c3c(O)[nH]c4cc(C#N)ccc34)nc2)CC1.Cl,,CN1CCCC1=O,,[H-].[Na+],,val
US20110105504A1,C[C@H](N)c1ccc(Br)cc1.O=C(CCl)c1ccc(F)cc1>>C[C@H](NCC(=O)c1ccc(F)cc1)c1ccc(Br)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20020193367A1,CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccnn3C)c2)cc1Cl>>CN(C)c1cc2c(cc1Cl)NC(=O)CC(c1cccc(-c3ccnn3C)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160083379A1,CC(C)(C)OC(=O)Nc1ccc2c(c1)OCC2(C)C.CI>>CNc1ccc2c(c1)OCC2(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20140275172A1,Cc1cc2cc(Cl)cc(COc3c(F)cc(CCC(=O)O)cc3F)c2s1>>Cc1cc2cc(Cl)cc(COc3c(F)cc(CCCO)cc3F)c2s1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150246912A1,CC(C)(C)[Si](C)(C)Cl.CC(C)(CO)n1cc(I)c2cnccc21.c1c[nH]cn1>>CC(C)(CO[Si](C)(C)C(C)(C)C)n1cc(I)c2cnccc21.N,,ClCCl,,,,val
US20100069328A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)/C=C/c1ccc(C(CCO[Si](C)(C)C(C)(C)C)C(=O)O)cc1.Nc1ccc(Br)cc1>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)/C=C/c1ccc(C(CCO[Si](C)(C)C(C)(C)C)C(=O)Nc2ccc(Br)cc2)cc1,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20150025070A1,CC(C)(C)OC(=O)N1CCC(C(=O)c2ccccn2)CC1>>O=C(c1ccccn1)C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140213580A1,COCCC(=O)N1CCN(c2nc(C(C)C)c(Br)cc2C#N)C[C@H]1C.OB(O)c1ccc(C(F)(F)F)cc1>>COCCC(=O)N1CCN(c2nc(C(C)C)c(-c3ccc(C(F)(F)F)cc3)cc2C#N)C[C@H]1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060106081A1,Nc1ccc(F)c([N+](=O)[O-])c1.O=S(=O)(Cl)c1ccc(F)cc1>>O=[N+]([O-])c1cc(NS(=O)(=O)c2ccc(F)cc2)ccc1F,,ClCCl,,c1ccncc1,,val
US20030203896A1,CC(C)(C)OC(=O)[C@H](CS)NS(=O)(=O)c1ccc(Br)cc1.CCOC(=O)CCCn1ccc2c(Cl)nc(C)nc21>>CCOC(=O)CCCn1ccc2c(SC[C@H](NS(=O)(=O)c3ccc(Br)cc3)C(=O)OC(C)(C)C)nc(C)nc21,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20050130983A1,CCCc1cn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(CCOC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)CC4)ccc3OCC)nc12.Cl.ClCCl>>CCCc1cn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(CCOC(=O)[C@@H](N)C(C)C)CC4)ccc3OCC)nc12.Cl.Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090118281A1,COC(=O)NC1Cc2ccccc2N(C(=O)CC(C)(C)C[C@H](NC(=O)OC(C)(C)C)[C@@H](O)CN=[N+]=[N-])C1>>COC(=O)NC1Cc2ccccc2N(C(=O)CC(C)(C)C[C@H](NC(=O)OC(C)(C)C)[C@@H](O)CN)C1,[Pd],CO,,,,val
US04820834,CN1C(=O)[C@@H](N)N=C(c2ccccc2)c2ccccc21.O=C(Cl)C1CCCCC1>>CN1C(=O)[C@@H](NC(=O)C2CCCCC2)N=C(c2ccccc2)c2ccccc21,,ClCCl,,CCN(CC)CC,,val
US20060264429A1,CC(C)(C)OC(=O)N1CCN(c2cccc3nc(-c4ccccc4)ccc23)CC1>>c1ccc(-c2ccc3c(N4CCNCC4)cccc3n2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150080438A1,CC=O.COc1cccc(C=O)c1F>>COc1cccc(/C=C/C=O)c1F,,ClCCl,O,[K+].[OH-],,val
US20110034450A1,C[Mg]I.Cc1ccc(C(=O)C(C)CC(F)(F)F)cc1>>C=C(c1ccc(C)cc1)C(C)CC(F)(F)F,,CCOCC,,Cl,,val
US20050014789A1,CCCCNC1CCN(C(=O)OC(C)(C)C)CC1.O=C(Cl)c1cccc2ccccc12>>CCCCN(C(=O)c1cccc2ccccc12)C1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CCN(CC)CC,,val
US20050159431A1,O=c1[nH]c(=O)n(CCc2ccc([N+](=O)[O-])cc2)c2c1CCCC2>>Nc1ccc(CCn2c3c(c(=O)[nH]c2=O)CCCC3)cc1,[Pd],C1CCOC1,CO,,,val
US04073894,C=O.O=c1[nH]c(=O)n(-c2c([N+](=O)[O-])cccc2[N+](=O)[O-])o1>>O=c1on(-c2c([N+](=O)[O-])cccc2[N+](=O)[O-])c(=O)n1CO,,CO,ClCCl,O,,val
US20160075713A1,CCOC(=O)C(F)(F)c1ccc(C(F)(F)F)nc1>>OCC(F)(F)c1ccc(C(F)(F)F)nc1,,CCO,,[BH4-].[Na+],,val
US20100056531A1,C1CCOC1.ClCCl.NC(=O)CCC(=O)NCl.O=S=O.[Li]CCCC>>O=S(=O)(Cl)c1ccc2c(c1)OCC2,,ClCCl,,,,val
US20110028501A1,Fc1ccc(-n2ccnn2)cn1.OCC[C@@H]1C[C@@H]1C1CCN(c2ncc(Cl)cn2)CC1>>Clc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(-n4ccnn4)cn3)CC2)nc1,,CN(C)C=O,,[H-].[Na+],,val
US20130338134A1,COc1cc(OC)cc(N2Cc3cnc4c(cc(C(=O)O)n4S(=O)(=O)c4ccccc4)c3N(C)C2=O)c1>>COc1cc(OC)cc(N2Cc3cnc4[nH]c(C(=O)O)cc4c3N(C)C2=O)c1,,C1CCOC1,O,Cl,CC(C)(C)[O-].[K+],val
US20060241120A1,CNC1(CO)CCN(c2ncnc3c2nc(-c2ccccc2Cl)n3-c2ccc(Cl)cc2)CC1.O=C(Cl)CCl>>CN1C(=O)COCC12CCN(c1ncnc3c1nc(-c1ccccc1Cl)n3-c1ccc(Cl)cc1)CC2,,ClCCl,,CCN(CC)CC,[Na+].[OH-],val
US20040006141A1,CCOC(=O)C(O)Cc1ccc(OCc2ccccc2)cc1.N#Cc1ccc(O)cc1>>CCOC(=O)C(Cc1ccc(OCc2ccccc2)cc1)Oc1ccc(C#N)cc1,,Cc1ccccc1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US08309542B2,CC(=Cc1cccs1)[N+](=O)[O-]>>CC(N)Cc1cccs1,,C1CCOC1,,[H-].[Na+],,val
US20060029545A1,COC(=O)CCCCCN(CCCCCC(=O)OC)C(=O)CCCCCN(CCCCCC(=O)N(CCCCCC(=O)OC)CCCCCC(=O)OC)C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>COC(=O)CCCCCN(CCCCCC(=O)OC)C(=O)CCCCCNCCCCCC(=O)N(CCCCCC(=O)OC)CCCCCC(=O)OC.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04812164,CC(C)=NOCCOS(=O)(=O)C(F)(F)F.COc1nc(C(F)(F)F)cc(=O)n1-c1cc(O)c(Cl)cc1F>>COc1nc(C(F)(F)F)cc(=O)n1-c1cc(OCCON=C(C)C)c(Cl)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US20090163714A1,Clc1ncnc2nc[nH]c12.FC(F)(F)Oc1cccc(-c2c[nH]c(C3CCNCC3)n2)c1>>FC(F)(F)Oc1cccc(-c2c[nH]c(C3CCN(c4ncnc5nc[nH]c45)CC3)n2)c1,,CC(C)O,,CCN(CC)CC,,val
US04078064,O=C(Cl)c1ccccc1.c1ccc(Oc2nc3ncnn3c3c2cnc2[nH]ncc23)cc1>>O=C(c1ccccc1)n1ncc2c1ncc1c(Oc3ccccc3)nc3ncnn3c12,,c1ccncc1,,,,val
US05834494,Clc1ccc2[nH]ccc2c1>>Clc1ccc2c(c1)CCN2,,CC(=O)O,,[BH3-]C#N.[Na+],,val
US20040063775A1,COC(=O)Cc1cn(C)nc1O.ClCc1ccc(OCc2csc(-c3ccccc3)n2)nc1>>COC(=O)Cc1cn(C)nc1OCc1ccc(OCc2csc(-c3ccccc3)n2)nc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090209609A1,COC(=O)Cc1c(C)n(C(=O)OC(C)(C)C)c2sc(C)cc12>>COC(=O)Cc1c(C)[nH]c2sc(C)cc12,,ClCCl,,,,val
US20150152112A1,CC(C)C(=N)N.CCOC(=O)CC(=O)c1cc(Cl)ccc1[N+](=O)[O-]>>CC(C)c1nc(-c2cc(Cl)ccc2[N+](=O)[O-])cc(=O)[nH]1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20150166527A1,COC(=O)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1>>Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@H]2C(=O)O)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20090318423A1,Nc1ccc2c(c1)CCN(C(=O)OCc1ccccc1)CC2.O=S(=O)(Cl)c1ccc(-c2ccccc2)cc1>>O=C(OCc1ccccc1)N1CCc2ccc(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)cc2CC1,,ClCCl,,c1ccncc1,,val
US20010012901A1,CCOC(=O)CCCOc1cc(C)cc(C)c1C.O=S(=O)(O)Cl>>CCOC(=O)CCCOc1cc(C)c(S(=O)(=O)Cl)c(C)c1C,,ClCCl,ClCCl,,,val
US05571816,CC1(C)CN(C(=N)NC=C(C#N)C(=O)N(CC2CC2)c2cccc(C(F)(F)F)c2)C(=O)N1.Cl>>CC1(C)CN(C(=N)NC=C(C#N)C(=O)N(CC2CC2)c2cccc(C(F)(F)F)c2)C(=O)N1.Cl,,O,,,,val
US20050256123A1,COC(=O)c1c(O)c(C)nn(C)c1=O>>Cc1nn(C)c(=O)cc1O,,C1COCCO1,CCOC(C)=O,Cl,,val
US20040097507A1,CCOC(=O)c1c(-c2ccncc2F)noc1C>>Cc1onc(-c2ccncc2F)c1C(=O)O,,C1CCOC1,,CCO,[Na+].[OH-],val
US20020102405A1,COCCOCCOCC(=O)O.O=C(Cl)C(=O)Cl.c1ccncc1>>COCCOCCCOCC(=O)Cl,,Cc1ccccc1,,,,val
US20100029653A1,Nc1nc(-n2nc(Cc3ccccc3F)c3ncccc32)nc(N)c1[N+](=O)[O-]>>Nc1nc(-n2nc(Cc3ccccc3F)c3ncccc32)nc(N)c1N,[Pd],c1ccncc1,,,,val
US20070112077A1,CC[Si](CC)(CC)OS(=O)(=O)C(F)(F)F.C[C@H](C=O)CCCC(C)(C)O>>CC[Si](CC)(CC)OC(C)(C)CCC[C@H](C)C=O,,ClCCl,,Cc1cccc(C)n1,,val
US20090209524A1,CCCCCNc1nc(N)nc(C)c1Cc1ccc(CO)cc1OC.O=S(Cl)Cl>>CCCCCNc1nc(N)nc(C)c1Cc1ccc(CCl)cc1OC,,ClCCl,,,,val
US20130178625A1,N#Cc1cccc(Nc2ccc3ccccc3c2[N+](=O)[O-])c1>>N#Cc1cccc(Nc2ccc3ccccc3c2N)c1,[Pd],C1CCOC1,,CO,,val
US04410534,COC(=O)C1CCCn2cccc21.O=C(Cl)c1ccc(F)cc1>>COC(=O)C1CCCn2c(C(=O)c3ccc(F)cc3)ccc21,,Cc1ccccc1C,,,,val
US20140323537A1,CC(C)Oc1ccc(-c2nn(C3CCCCO3)cc2C=O)cc1Cl>>CC(C)Oc1ccc(-c2n[nH]cc2C=O)cc1Cl,,Cl,,,,val
US20140106969A1,COC1CS(=O)(=O)c2ccc(C(=O)O)c(Cl)c21.Cc1nonc1N>>COC1CS(=O)(=O)c2ccc(C(=O)Nc3nonc3C)c(Cl)c21,CN(C)c1ccncc1,ClCCl,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US04666915,CCOC(=O)c1cnc(Nc2cccc(C(F)(F)F)c2)[nH]c1=O>>O=C(O)c1cnc(Nc2cccc(C(F)(F)F)c2)[nH]c1=O,,CC(=O)O,,O,[Na+].[OH-],val
US20020045761A1,CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(-c3ccccc3)nc(Cl)c2C=O)c(Cl)c1>>NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(-c3ccccc3)nc(Cl)c2C=O)c(Cl)c1,,O=C(O)C(F)(F)F,,COc1ccccc1,,val
US04600715,CCOC(=O)c1ncc2[nH]c3ccc(C(=O)OCc4ccccc4)cc3c2c1CC>>CCOC(=O)c1ncc2[nH]c3ccc(C(=O)O)cc3c2c1CC,[Pd],CO,,Cl,,val
US20100056527A1,CCOC(=O)c1cccc(Cc2cc(Cl)cc3cc(-c4ccccc4)oc23)n1>>O=C(O)c1cccc(Cc2cc(Cl)cc3cc(-c4ccccc4)oc23)n1,,CCO,,[Na+].[OH-],,val
US05409939,NN=Cc1ccc(CCCCC(=O)NC(CC(=O)O)CS(=O)c2ccccc2)cc1.OO>>NN=Cc1ccc(CCCCC(=O)NC(CC(=O)O)CS(=O)(=O)c2ccccc2)cc1,,O,,CC(=O)O,,val
US04758669,O=[N+]([O-])c1cccc(CO)c1>>OCc1cccc(NO)c1,[Zn],CCO,,[Cl-].[NH4+],,val
US20020193398A1,CCOC(=N)c1ccccc1C#N.CCOC(CN)OCC.Cl>>Cl.N#Cc1ccccc1-c1ncc[nH]1,,CO,,,,val
US20090131664A1,C1CCNC1.Cc1ccccc1.OCCCCl>>Cc1ccccc1.OCCCN1CCCC1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20110118234A1,Cc1cc(-c2ccc(N)cc2)ccn1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>Cc1cc(-c2ccc(NC(=O)Oc3ccc([N+](=O)[O-])cc3)cc2)ccn1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20160052884A1,O=c1[nH]cc(-c2ccc([N+](=O)[O-])cc2)o1>>Nc1ccc(-c2c[nH]c(=O)o2)cc1,[Pd],CCO,,,,val
US20130158001A1,CCOC(=O)CCCC1(c2ccccc2)CCCCC1>>O=C(O)CCCC1(c2ccccc2)CCCCC1,,CO,,Cl,[Na+].[OH-],val
US20090197880A1,O=C(CCl)N1CCCCC1.Oc1ccc(-c2cc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)on2)c(C(F)(F)F)c1>>O=C(COc1ccc(-c2cc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)on2)c(C(F)(F)F)c1)N1CCCCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130005716A1,O=C(O)CC1SCCN1S(=O)(=O)c1ccccc1.[O-][n+]1cc(Cl)c(C[C@H](O)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1>>O=C(CC1SCCN1S(=O)(=O)c1ccccc1)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20130131039A1,CC1(C)OB(c2cnn(COCC[Si](C)(C)C)c2)OC1(C)C.Clc1nc(-c2ccc(Br)cc2)cc2nccn12>>C[Si](C)(C)CCOCn1cc(-c2nc(-c3ccc(Br)cc3)cc3nccn23)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O,O=C([O-])[O-].[K+].[K+],val
US05998459,CC(Br)C(=O)c1ccccc1.N=C(N)CC(N)=O>>Cc1c(-c2ccccc2)[nH]c(N)c1C(N)=O,,CCO,,,,val
US20080269192A1,CCOC(=O)CC(C)Nc1c([N+](=O)[O-])cnc2ccccc12>>CCOC(=O)CC(C)Nc1c(N)cnc2ccccc12,[Pt],CC#N,,,,val
US20100173880A1,O=C(O)C(Nc1cccc(F)c1)c1ccc(F)cc1.O[C@H]1CN2CCC1CC2>>O=C(O[C@H]1CN2CCC1CC2)C(Nc1cccc(F)c1)c1ccc(F)cc1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20120329784A1,CNS(=O)(=O)c1cccc(Nc2cc(Nc3ncc(C(=O)OC)s3)ncn2)c1>>CNS(=O)(=O)c1cccc(Nc2cc(Nc3ncc(C(=O)O)s3)ncn2)c1,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20100041645A1,COC(=O)c1cccc(CN(Cc2ccccc2)C(=O)Nc2ccc(C#N)cc2)c1>>N#Cc1ccc(NC(=O)N(Cc2ccccc2)Cc2cccc(C(=O)O)c2)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20110201605A1,Cc1nnc(N2CCC(=NOCc3ccccc3)CC2)o1>>Cc1nnc(N2CCC(N)CC2)o1,[Pd],CO,N,,,val
US20160251306A1,CCO.Cc1cccnc1C(=O)O>>CCOC(=O)c1ncccc1C,,CCOC(C)=O,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20140171517A1,CC(O)=S.CC=CC(=O)C(C)CC>>CCC(C)C(=O)CC(C)SC(C)=O,C1CCNCC1,,,,,val
US20050113283A1,C=CCN=C=O.O=C(CC(=O)C(F)(F)F)Nc1cc(-c2ccccc2)n[nH]1>>C=CCNC(=O)n1nc(-c2ccccc2)cc1NC(=O)CC(=O)C(F)(F)F,,CN(C)C=O,,,,val
US20160016967A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1cc(N)ccc1Br>>COc1cc(NC(=O)OC(C)(C)C)ccc1Br,,C1CCOC1,,CCN(CC)CC,,val
US20150112067A1,CC(=O)Cc1ccccc1C.CC(C)OC(=O)C(COS(C)(=O)=O)NC(=O)OC(C)(C)C>>CC(=O)C(CC(NC(=O)OC(C)(C)C)C(=O)OC(C)C)c1ccccc1C,,C1CCOC1,CS(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070155721A1,CCOC(=O)c1cc2c(Oc3cc(F)cc(F)c3[N+](=O)[O-])cccc2[nH]1>>CCOC(=O)c1cc2c(Oc3cc(F)ccc3N)cccc2[nH]1,[Pd],CCOC(C)=O,,,,val
US20070099990A1,CCC[Mg]Br.Cc1cc(C)c(Cc2ccc(C(C)C)cc2)c(OCC(=O)N2CC2C)c1>>CCCC(=O)COc1cc(C)cc(C)c1Cc1ccc(C(C)C)cc1,,C1CCOC1,,O,,val
US20070027163A1,N.O=C(O)Cn1cc(C(=O)N2CCN(c3ccccc3F)CC2)c2ccc(Cl)cc21>>NC(=O)Cn1cc(C(=O)N2CCN(c3ccccc3F)CC2)c2ccc(Cl)cc21,,C1CCOC1,,,,val
US20150376160A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4sc(Cl)cc4NC(=O)O[C@H](C)c4ccc(F)cc4Cl)cc3)cc2)CC1>>C[C@@H](OC(=O)Nc1cc(Cl)sc1-c1ccc(-c2ccc(C3(C(=O)O)CC3)cc2)cc1)c1ccc(F)cc1Cl,,CC(C)O,,Cl,[Na+].[OH-],val
US20130231329A1,CN1CCC(NC(c2cccc(OC3CCCCO3)c2)c2nc3ccccc3[nH]2)CC1>>CN1CCC(NC(c2cccc(O)c2)c2nc3ccccc3[nH]2)CC1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20110201604A1,CN(CCOCCN(Cc1ccccc1)Cc1ccccc1)C(=O)OC(C)(C)C>>CN(CCOCCN)C(=O)OC(C)(C)C,[Pd],CO,,,,val
US07423059B2,Cl.c1ccc(C2CCC(c3ccccc3)N2)cc1>>Cl.c1ccc(C2CCC(c3ccccc3)N2)cc1,,CCOCC,O,O=C(O)C(F)(F)F,[Na+].[OH-],val
US06512136B1,COc1cc(C=O)ccc1OCc1ccccc1.Cl[Mg]Cc1ccccc1>>COc1cc(C(O)Cc2ccccc2)ccc1OCc1ccccc1,,C1CCOC1,CCOCC,,,val
US20110237791A1,COc1ccc(CN2C(=O)CC[C@@H]2/C=C(\c2ccc(C(F)(F)F)cc2)c2ccc(OC3CCCC3)c(OC)n2)c(OC)c1>>O=C1CC[C@H](/C=C(\c2ccc(C(F)(F)F)cc2)c2ccc(OC3CCCC3)c(=O)[nH]2)N1,,C1COCCO1,,Br,O,val
US20150353533A1,CCOC(=O)c1cc(CN(C)c2ccccc2)n(C(C)=O)n1>>CN(Cc1cc(C(=O)O)n[nH]1)c1ccccc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US04284631,O=C1NC(=O)c2ccccc21.O=C1c2ccccc2C(=O)N1OCc1ccc(CCl)cc1>>O=C1c2ccccc2C(=O)N1Cc1ccc(CON2C(=O)c3ccccc3C2=O)cc1,,CN(C)C=O,,[K],,val
US20110237791A1,COc1nc(Br)ccc1N.[I-]>>COc1nc(Br)ccc1I,,Cl,O,O=N[O-].[Na+],,val
US20120329780A1,COc1cc(C(=O)N2CCC(N3CCN(C)CC3)CC2)ccc1N.COc1ccc(Cn2cc3nc(-c4cccs4)nc(Cl)c3n2)cc1>>COc1cc(C(=O)N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1nc(-c2cccs2)nc2cn[nH]c12,C1COCCO1,CO,,Cl,,val
US20020028938A1,CS(=O)(=O)c1ccc(-c2cn[nH]c(=O)c2Cc2ccc(F)cc2)cc1.Fc1ccc(Br)cc1F>>CS(=O)(=O)c1ccc(-c2cnn(-c3ccc(F)c(F)c3)c(=O)c2Cc2ccc(F)cc2)cc1,,O,,N,,val
US20070299091A1,O=C1c2ccccc2C(=O)N1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1>>NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1,,CCO,,NN,O,val
US20030229079A1,BrC(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ncc[nH]1>>O=Cc1nccn1C(c1ccccc1)(c1ccccc1)c1ccccc1,,CN(C)C=O,,CCN(CC)CC,O,val
US06090753,CCOC(=O)C=Cc1cc(N)ccc1Cl.O=N[O-]>>CCOC(=O)C=Cc1cc(NN)ccc1Cl,,Cl,,Cl[Sn]Cl,,val
US20100016245A1,BrBr.CCCC(=O)O[C@@H]1[C@@H](OC(=O)CCC)[C@H](C)O[C@@H](Sc2ccccc2)[C@@H]1OCc1ccccc1>>CCCC(=O)O[C@@H]1[C@@H](OC(=O)CCC)[C@H](C)O[C@@H](Br)[C@@H]1OCc1ccccc1,,ClCCl,,,,val
US20080004295A1,CNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3ccn(S(=O)(=O)c4ccc(C)cc4)c3n2)cc1>>CNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3ccnc-3[nH]2)cc1,,CO,,C[O-].[Na+],,val
US20160072082A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1ccc(Br)c(C#N)c1>>COc1ccc(B2OC(C)(C)C(C)(C)O2)c(C#N)c1,,C1COCCO1,CS(C)=O,CC(=O)[O-].[K+],,val
US20100062311A1,O=C(Cl)c1cc(Cl)ccc1Cl.c1cc[nH]c1>>O=C(c1ccc[nH]1)c1cc(Cl)ccc1Cl,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20070078135A1,CCNC1(C(N)=O)CCNCC1.Clc1cncc(Cl)n1>>CCNC1(C(N)=O)CCN(c2cncc(Cl)n2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05580887,Fc1ccc2c(N3CCNCC3)n[nH]c2c1.O=C1c2ccccc2C(=O)N1CCBr>>O=C1c2ccccc2C(=O)N1CCN1CCN(c2n[nH]c3cc(F)ccc23)CC1,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20060270656A1,CC(C)c1nc(C#N)c(C(=O)c2ccccc2[N+](=O)[O-])s1>>CC(C)c1nc2c(N)nc3ccccc3c(=O)c2s1,,C1COCCO1,Cl,Cl[Sn]Cl,,val
US05750531,CC1c2ccccc2CCN1c1nc(Cl)c2cccc-2[nH]1.Cc1cc(F)ccc1N>>Cc1cc(F)ccc1Nc1nc(N2CCc3ccccc3C2C)[nH]c2cccc1-2.Cl,,CN(C)C=O,,,,val
US20090239854A1,CCOC(=O)CC(C)=O.Cc1ccc(N(N)CCc2ccccc2)cc1>>CCOC(=O)c1c(C)n(CCc2ccccc2)c2ccc(C)cc12,,Cl,,,,val
US20130210818A1,BrBr.COc1cc(-c2csc(-c3ccc(F)cc3)n2)cnc1N>>COc1cc(-c2nc(-c3ccc(F)cc3)sc2Br)cnc1N,,ClC(Cl)Cl,,,,val
US20150065705A1,CCOC(OCC)OCC.CSC(=N)NC(=O)NCc1ccc(C(F)(F)F)s1>>CSc1ncn(Cc2ccc(C(F)(F)F)s2)c(=O)n1,,CCO,,,,val
US20100152216A1,COC(=O)CN1C(=O)N(C(C)C)C(=O)C1(C)c1ccccc1>>CC(C)N1C(=O)N(CC(=O)O)C(C)(c2ccccc2)C1=O,,CO,,[Na+].[OH-],,val
US20040048868A1,CCOC(=O)C(=O)OCC.O=C1CCCCC1>>CCOC(=O)C(=O)C1CCCCC1=O,,CCO,,[Na],,val
US06251911B1,Nc1n[nH]c2ncnc(Nc3cccc(Cl)c3)c12.O=Cc1ccoc1>>Clc1cccc(Nc2ncnc3[nH]nc(N=Cc4ccoc4)c23)c1,,CO,,CC(=O)O,,val
US20050256158A1,CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(Cl)c1ccc(-n2ccc(C(F)(F)F)n2)cc1.O=C(Cl)c1ccc(F)cc1.O=C(O)c1ccc(-n2ccc(C(F)(F)F)n2)cc1>>CC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2ccc(-n3ccc(C(F)(F)F)n3)cc2)c2ccccc21,,CN(C)C=O,,,,val
US20130109667A1,Nc1ncc(F)cn1.O=S(=O)(Cl)c1cc(Cl)c(F)cc1F>>O=S(=O)(Nc1ncc(F)cn1)c1cc(Cl)c(F)cc1F,,ClCCl,c1ccncc1,,,val
US20080214495A1,Cn1nc(Cl)ccc1=O.O=C(c1ccc(S(=O)(=O)c2ccc3cc(Br)ccc3c2)cc1)C1CCNCC1>>Cn1nc(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5cc(Br)ccc5c4)cc3)CC2)ccc1=O,,CCO,O,CCN(CC)CC,Cl,val
US06297234B1,O=C(Cl)c1ccc(Br)cc1Cl.c1ccc2c(c1)Cn1cccc1CN2>>O=C(c1ccc(Br)cc1Cl)N1Cc2cccn2Cc2ccccc21,,ClCCl,,CCN(CC)CC,,val
US20050113419A1,CC(C)N=C=O.CCCc1c(OCCC(NC)OCCCBr)ccc2c(C(F)(F)F)noc12>>CCCc1c(OCCCN(C)C(=O)NC(C)C)ccc2c(C(F)(F)F)noc12,,c1ccncc1,,,,val
US20070078135A1,CCNC1(C(N)=O)CCN(c2cncc(Cl)n2)CC1.O=C1CCC(=O)N1Br>>CCNC1(C(N)=O)CCN(c2cnc(Br)c(Cl)n2)CC1,,ClC(Cl)Cl,ClCCl,,,val
US20160244417A1,COC(=O)[C@@H]1C[C@@H](F)CC[C@H]1c1nc(-c2cncc(F)c2)sc1-c1ccc(N2CCS(=O)(=O)CC2)cc1>>O=C(O)[C@@H]1C[C@@H](F)CC[C@H]1c1nc(-c2cncc(F)c2)sc1-c1ccc(N2CCS(=O)(=O)CC2)cc1,,C1CCOC1,,CO,[Na+].[OH-],val
US20050153955A1,O=C1NCCC(=O)c2c1[nH]c(Br)c2Br>>O=C1NCCC(O)c2c1[nH]c(Br)c2Br,,CN(C)C=O,CO,[BH4-].[Na+],,val
US20100184761A1,CN1CCC[C@H]1C(=O)O.CNCCOc1ccc(-c2cc3c(ncn3C)c(C#N)n2)cc1C(F)(F)F>>CN(CCOc1ccc(-c2cc3c(ncn3C)c(C#N)n2)cc1C(F)(F)F)C(=O)[C@@H]1CCCN1C,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110083984A1,COc1c(OCCCN2CCOCC2)ccc(C#N)c1[N+](=O)[O-]>>COc1c(OCCCN2CCOCC2)ccc(C#N)c1N,[Fe],CC(=O)O,,O,,val
US20060199956A1,CC1(C)OCCn2c1nc(C(=O)NCc1ccc(F)cc1-c1ccn[nH]1)c(OCc1ccccc1)c2=O.CI>>Cn1ccc(-c2cc(F)ccc2CNC(=O)c2nc3n(c(=O)c2OCc2ccccc2)CCOC3(C)C)n1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20080103123A1,CC(C)(C)OC(=O)N1CCC(N(Cc2ccc(-c3ccc(S(C)(=O)=O)cc3)nc2)C2CC2)CC1>>CS(=O)(=O)c1ccc(-c2ccc(CN(C3CCNCC3)C3CC3)cn2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160122342A1,CCN(c1cccc2c1CC=CCCc1cc(C)nc(OC)c1CNC2=O)C1CCC(NC(=O)OC(C)(C)C)CC1.O=C(O)C(F)(F)F>>CCN(c1cccc2c1CC=CCCc1cc(C)nc(OC)c1CNC2=O)[C@@H]1CC[C@H](N)CC1.O=CO,,ClCCl,,,,val
US20090137773A1,NCCO.O=S(=O)(Cl)CCC(F)(C(F)(F)F)C(F)(F)F>>O=S(=O)(CCC(F)(C(F)(F)F)C(F)(F)F)NCCO,,ClCCl,,,,val
US20150246908A1,COC(=O)CNC(=O)/C=C/c1cccc(Cl)c1>>O=C(O)CNC(=O)/C=C/c1cccc(Cl)c1,,CO,,Cl,[Na+].[OH-],val
US06225320B1,CCOC(CN)OCC.O=C(Nc1cnc(Cl)c(Br)c1)C(F)(F)F>>FC(F)(F)c1nccn1-c1cnc(Cl)c(Br)c1,,ClC(Cl)(Cl)Cl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20110098324A1,CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(Cc2ccccc2Cl)c1=O.C[C@@H](N)c1ccc(Cl)cc1>>C[C@@H](NC(=O)c1c(O)c(C(=O)NCC(=O)O)c(=O)n(Cc2ccccc2Cl)c1O)c1ccc(Cl)cc1,,ClC(Cl)Cl,,,,val
US20150246063A1,CC(C)OB(OC(C)C)OC(C)C.C[C@H]1CC[C@@H](Oc2ccc3cc(Br)ccc3c2C(F)(F)F)CC1>>C[C@@H]1CC[C@H](Oc2ccc3cc(B(O)O)ccc3c2C(F)(F)F)CC1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US05679700,CC(C)C[C@H](N)C(=O)Nc1ccccc1.O=C(O)C(CCc1ccccc1)CP(=O)(O)CCCCN1C(=O)c2ccccc2C1=O>>CC(C)C[C@H](NC(=O)C(CCc1ccccc1)CP(=O)(O)CCCCN1C(=O)c2ccccc2C1=O)C(=O)Nc1ccccc1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US05202319,CCOC(=O)Cl.NN1CCc2ccccc2C(Oc2ccc(C(F)(F)F)cc2)C1>>CCOC(=O)NN1CCc2ccccc2C(Oc2ccc(C(F)(F)F)cc2)C1,,ClCCl,,O=C([O-])O.[Na+],,val
US20130064770A1,O=C(NCCCN1CCN(Cc2ccccc2)CC1)C1CCCCC1>>O=C(NCCCN1CCNCC1)C1CCCCC1,[Pd],CC(=O)O,,Cl,O=C([O-])[O-].[K+].[K+],val
US07091199B1,BrCCOc1cccc(-c2noc3ccsc23)c1.NCc1c(F)cccc1F>>Fc1cccc(F)c1CNCCOc1cccc(-c2noc3ccsc23)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110300165A1,CC(C)(C)OC(=O)C1CN(Cc2ccc(/C(N)=N/O)cc2)C1.O=C(F)c1onc(-c2ccccc2)c1C(F)(F)F>>CC(C)(C)OC(=O)C1CN(Cc2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20090082434A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCC1Cc2cc(Cl)cc(C3CCCCC3)c2O1>>Cc1ccc(S(=O)(=O)OCC2Cc3cc(Cl)cc(C4CCCCC4)c3O2)cc1,CN(C)c1ccncc1,,,CCN(C(C)C)C(C)C,,val
US20030216403A1,CCC(N)=S.CCOC(=O)C(=NO)C(=O)CCl>>CCOC(=O)C(=NO)c1csc(CC)n1,,c1ccccc1,,,,val
US20030139415A1,CC(C)(C)[C@@H]1CC[C@H](C(=O)O)CC1.O=C(Cl)C(=O)Cl>>CC(C)(C)[C@@H]1CC[C@H](C(=O)Cl)CC1,,ClCCl,,,,val
US20020055507A1,CC(=O)N1C(=O)Cc2ccccc21.CI.CS(C)=O>>CC(=O)N1C(=O)C(C)(C)c2ccccc21,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20150329538A1,N.O=C(c1cc(Br)c[nH]1)C(Cl)(Cl)Cl>>NC(=O)c1cc(Br)c[nH]1,,CC#N,,,,val
US05439909,O=C(C1=COc2cc(O)ccc2O1)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1>>Oc1ccc2c(c1)OC=C(CN1CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC1)O2,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US07074801B1,CN.O=S(=O)(Cl)c1ccc(-c2ncnc3ccc(Br)cc23)s1>>CNS(=O)(=O)c1ccc(-c2ncnc3ccc(Br)cc23)s1,,C1CCOC1,,,,val
US20120028931A1,CCOP(OCC)OCC.ClCc1cc2sc3ccccc3c2s1>>CCOP(=O)(Cc1cc2sc3ccccc3c2s1)OCC,,Cc1ccccc1C,,,,val
US20050171101A1,Cl.Clc1ccc(C2=CCNCC2)cc1.O=c1[nH]c2cc(CCBr)ccc2c2c1CCCC2>>Cl.O=c1[nH]c2cc(CCN3CC=C(c4ccc(Cl)cc4)CC3)ccc2c2c1CCCC2,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,O,val
US20050124605A1,CCN(CC)CC.O=C(Cl)COCc1ccccc1.O=C1CC=C(c2ccccc2)c2ccccc2N1c1ccccc1>>O=C1CN2C(=O)[C@@H](OCc3ccccc3)[C@]2(c2ccccc2)c2ccccc2N1c1ccccc1,,CCOC(C)=O,ClCCl,,,val
US20140256677A1,Fc1ccc(-c2cc3ncccn3n2)cc1.O=C1CCC(=O)N1Br>>Fc1ccc(-c2nn3cccnc3c2Br)cc1,,ClC(Cl)Cl,,O,,val
US20100120770A1,CN1CCC(C#N)(c2ccccn2)CC1>>CN1CCC(CN)(c2ccccn2)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040082604A1,CCOC(=O)N1CCNCC1.Nc1nc(Cl)ccc1[N+](=O)[O-]>>CCOC(=O)N1CCN(c2ccc([N+](=O)[O-])c(N)n2)CC1,,CC(C)O,,,,val
US20150344711A1,Cc1cc(C)c(C(=O)P(=O)(C(=O)c2c(C)cc(C)cc2C)c2ccccc2)c(C)c1.Clc1ccccc1.O=C1CCC(=O)N1Br>>BrCc1ccccc1.Cc1cc(C)c(C(=O)P(=O)(C(=O)c2c(C)cc(C)cc2C)c2ccccc2)c(C)c1,,O,,,,val
US20040132727A1,COc1cc2nccc(Oc3ccc(NC(=O)COc4ccccc4)cc3)c2cc1OC>>COc1cc2nccc(Oc3ccc(NCCOc4ccccc4)cc3)c2cc1OC,,C1CCOC1,,Cl,[Na+].[OH-],val
US20060079521A1,COC(=O)c1ccc(OC)c(N)c1.N#Cc1ccc([N+](=O)[O-])cc1>>COC(=O)c1ccc(OC)c(NC(=N)c2ccc([N+](=O)[O-])cc2)c1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20070117839A1,O=C1CCC=C[C@@H]2CCC[C@H](c3ccc(F)cc3)N12>>O=C1CCCC[C@@H]2CCC[C@H](c3ccc(F)cc3)N12,O=[Pt],CO,,[H][H],,val
US20130079338A1,FC(F)(F)Oc1ccc(Nc2ncc(COc3ccc4c(c3)c(C(F)(F)F)nn4C3CCCCO3)cn2)cc1>>FC(F)(F)Oc1ccc(Nc2ncc(COc3ccc4[nH]nc(C(F)(F)F)c4c3)cn2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030055071A1,COC(=O)c1[nH]c(=O)c2cccnc2c1O.O=C(OC(=O)c1ccccc1)c1ccccc1>>COC(=O)c1[nH]c(=O)c2cccnc2c1OC(=O)c1ccccc1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20150329524A1,CCC=O.Nc1cc(Br)ccc1C=O>>Cc1cnc2cc(Br)ccc2c1,,CCO,,[K+].[OH-],,val
US06211199B1,COc1cc(CCl)cc(OC)c1OC.O=C1CCCN1>>COc1cc(CN2CCCC2=O)cc(OC)c1OC,,C1CCOC1,,[Li]C(C)CC,,val
US20110054173A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)Oc1ccc(CCNc2ncnc3nccnc23)cc1>>CC(C)(C)OC(=O)N(CCc1ccc(O[Si](C)(C)C(C)(C)C)cc1)c1ncnc2nccnc12,CN(C)c1ccncc1,CN(C)C=O,O,,,val
US03932472,CCCCCC(CC[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)OCC)SC(C)=O>>CCCCCC(S)CC[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)OCC,,CO,,C[O-].[Na+],,val
US20060167246A1,BrC1C=CCCC1.COC(=O)c1cc2[nH]c(-c3ccc(OCc4ccccc4)cc3OCc3ccccc3)cc2s1>>COC(=O)c1cc2[nH]c(-c3ccc(OCc4ccccc4)cc3OCc3ccccc3)c(C3C=CCCC3)c2s1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20160108033A1,Cn1cnc(-c2cc(-c3nn[nH]c3[Si](C)(C)C)ccn2)c1>>Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1,,CO,,O,[Na+].[OH-],val
US20150024935A1,CC(=NO)c1ccc(F)cc1.CCOC(=O)CBr>>CCOC(=O)CON=C(C)c1ccc(F)cc1,,CC#N,,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20080119465A1,Cc1cc(O)ccc1CC(=O)O.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)Cc1ccc(OS(=O)(=O)C(F)(F)F)cc1C,,ClCCl,,CCN(CC)CC,,val
US20100311777A1,COC(=O)C1(NC(=O)Cc2cc(C)ccc2C)CCN(OC)CC1>>CON1CCC2(CC1)NC(=O)C(c1cc(C)ccc1C)=C2O,,CN(C)C=O,,C[O-].[Na+],,val
US04426382,C1CCOC1.COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC.O=C(Cl)C=C1CCCC1>>COc1cc2nc(N3CCN(C(=O)C=C4CCCC4)CC3)nc(N)c2cc1OC.Cl.O,,CCN(CC)CC,,,,val
US20120108583A1,COC(=O)c1cc2nc(Nc3c(Cl)cccc3Cl)[nH]c2c2c1OC(C)(C)C2.Nc1cc(F)c(F)cc1F>>CC1(C)Cc2c(c(C(=O)Nc3cc(F)c(F)cc3F)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1,,Cc1ccccc1,,C[Al](C)C,,val
US20110082173A1,CCN(CC)C(=O)c1ccc(C(=C2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc2N)cc1.O=S(=O)(Cl)c1ccccc1>>CCN(CC)C(=O)c1ccc(C(=C2CCNCC2)c2ccccc2NS(=O)(=O)c2ccccc2)cc1,,c1ccncc1,,O=C(O)C(F)(F)F,,val
US20120270865A2,COC(=O)c1ccc(NC(c2oc3ccc(OCC4CC4)cc3c2C)C(C)C)nc1>>Cc1c(C(Nc2ccc(C(=O)O)cn2)C(C)C)oc2ccc(OCC3CC3)cc12,,CCO,,C1CCOC1,[Na+].[OH-],val
US20070276088A1,CC(C)(Br)C(=O)O.OCCCc1cccnc1S>>CC(C)(Br)C(=O)O.CCCc1cccnc1S,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100298324A1,COc1cnc(-n2c(=S)[nH]c3cc(C(=O)O)cc(Cl)c3c2=O)nc1OC.NCc1cccc(Cl)c1>>COc1cnc(-n2c(=S)[nH]c3cc(C(=O)NCc4cccc(Cl)c4)cc(Cl)c3c2=O)nc1OC,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120004381A1,CNc1ccncc1.N#CCBr.S=C=S>>CN(C(=S)SCC#N)c1ccncc1,,C1CCOC1,,[Li]CCCC,,val
US20030187020A1,CC(C)(C)OC(=O)N1CCC(O)(c2cccc(C#N)c2)CC1>>CC(C)(C)OC(=O)N1CCC(O)(c2cccc(CN)c2)CC1,[Rh],CO,N,,,val
US20130029961A1,CC1(C)OCC(c2ccc(NC(=O)Oc3ccccc3)cn2)O1.CC1CCN(c2nc(C(F)(F)F)ccc2CN)CC1>>CC1CCN(c2nc(C(F)(F)F)ccc2CNC(=O)Nc2ccc(C3COC(C)(C)O3)nc2)CC1,CN(C)c1ccncc1,CC#N,,,,val
US20020058681A1,CC(C)I.NS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2O)cc1F>>CC(C)Oc1cc(C(F)(F)F)nn1-c1ccc(S(N)(=O)=O)c(F)c1,,CN(C)C=O,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20140364411A1,CN1CCN(Cc2cc(Cl)c(-c3nnc4ccc(F)cn34)c(Cl)c2)CC1.N[C@H]1CC[C@@H](O)c2ccccc21>>CN1CCN(Cc2cc(Cl)c(-c3nnc4ccc(O[C@@H]5CC[C@H](N)c6ccccc65)cn34)c(Cl)c2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US04971982,CC(C)=CC(O)(c1ccccc1O)c1ncccc1C>>Cc1cccnc1C1=CC(C)(C)Oc2ccccc21,,COCCOCCOC,,,,val
US20100173888A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](NC(=O)C(F)(F)F)CC1.COS(=O)(=O)c1ccc(C)cc1>>CN(C(=O)C(F)(F)F)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090137595A1,CCOC(=O)c1cn(C)nn1>>Cn1cc(C(=O)O)nn1,,CO,,Cl,[Na+].[OH-],val
US20050026987A1,COC(=O)CN=[N+]=[N-].O=Cc1cccc(C2OCCO2)c1>>COC(=O)C(=Cc1cccc(C2OCCO2)c1)N=[N+]=[N-],,CO,,C[O-].[Na+],,val
US04645771,C1=CCNCC1.O=Cc1ccc(O)cc1>>Oc1ccc(CN2CC=CCC2)cc1,,CO,,Cl,[BH3-]C#N.[Na+],val
US03954776,CC1CCCC(C)N1.COCCOc1ccccc1OCC(O)CCl>>COCCOc1ccccc1OCC(O)CN1C(C)CCCC1C,,CCO,,,,val
US06110934,CN1CCc2c(N)cccc2C1.COc1cc(C)c(Cl)cc1C(=O)O>>COc1cc(C)c(Cl)cc1C(=O)Nc1cccc2c1CCN(C)C2,,CN(C)C=O,,On1nnc2ccccc21,,val
US20150299120A1,C=[N+]=[N-].CC(C)(C)OC(=O)NC1(C(=O)O)CCCC1OCc1ccccc1>>COC(=O)C1(NC(=O)OC(C)(C)C)CCCC1OCc1ccccc1,,CCOCC,,,,val
US20150105367A1,CNc1cc2nc(C)c(-c3cc(NC(=O)NCCc4ccccc4)c(F)cc3C)cc2cn1.Cl>>CNc1cc2nc(C)c(-c3cc(NC(=O)NCCc4ccccc4)c(F)cc3C)cc2cn1.Cl,,CC#N,,,,val
US20030036557A1,C=C(Cl)CCl.Oc1ccc(Cl)cc1>>C=C(Cl)COc1ccc(Cl)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080269194A1,COc1ccc(C2=NC(Cc3ccccc3Cl)C(=O)Nc3ccc(Cl)cc32)cc1>>O=C1Nc2ccc(Cl)cc2C(c2ccc(O)cc2)=NC1Cc1ccccc1Cl,,CC(Cl)Cl,ClCCl,BrB(Br)Br,,val
US20120149676A1,CN.O=C(O)c1cc([N+](=O)[O-])c(F)c(F)c1F>>CNc1c([N+](=O)[O-])cc(C(=O)O)c(F)c1F,,O,,Cl,,val
US20120252758A1,COC(=O)c1ccc(-c2ccnc(C)c2)c(OC)n1.Cl>>Cc1cc(-c2ccc(C(=O)O)[nH]c2=O)ccn1.Cl,,C1COCCO1,,,,val
US06337331B1,Cn1ncnc1CO.O=c1[nH]c2c(-c3ccccc3F)nnn2cc1C1CCC1>>Cn1ncnc1COc1nc2c(-c3ccccc3F)nnn2cc1C1CCC1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04789683,CCCN1CCCC1CN.COc1ccc(Br)c(OC)c1C(=O)O>>CCCN1CCCC1CNC(=O)c1c(OC)ccc(Br)c1OC,,ClC(Cl)Cl,,,,val
US04978753,CCSc1cc2c(cc1CC)C(c1ccc(C)cc1)=NCC(N)=N2.O=C(O)C#CCN1CCCC1>>CCSc1cc2c(cc1CC)C(c1ccc(C)cc1)=NCc1nc(=O)cc(CN3CCCC3)n1-2,,C1CCOC1,CN(C)C=O,O=C(n1ccnc1)n1ccnc1,,val
US20030092676A1,COC(=O)CCBr.O=Cc1cccc2cc[nH]c12>>COC(=O)C1=Cc2cccc3ccn(c23)C1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080242706A1,CI.Cc1[nH]cc(CC(F)(F)F)c(=O)c1OCc1ccccc1>>Cc1c(OCc2ccccc2)c(=O)c(CC(F)(F)F)cn1C,,CC#N,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20100240638A1,COC(=O)CCCCCCCC(=O)[O-]>>COC(=O)CCCCCCCCO,,C1CCOC1,,,,val
US20110105463A1,CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)O)cc3)c(Cl)cc21.NC1CCCC(c2ccccc2)C1>>CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)NC4CCCC(c5ccccc5)C4)cc3)c(Cl)cc21,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,CCN=C=NCCCN(C)C,Cl,val
US04255432,Cl.O=C1NCC2(CCN(CCc3c[nH]c4ccccc34)CC2)O1>>Cl.O=C1NCC2(CCN(CCc3c[nH]c4ccccc34)CC2)O1,,CC(C)O,,CCOCC,,val
US20100280043A1,CC(C)(C)OC(=O)N1CCN(c2ccnc3[nH]nc(I)c23)CC1.COc1ccc(CCl)cc1>>COc1ccc(Cn2nc(I)c3c(N4CCN(C(=O)OC(C)(C)C)CC4)ccnc32)cc1,,CN(C)C=O,O,CCOCC,O=C([O-])[O-].[K+].[K+],val
US04831041,CC(=O)Nc1cccc(NC(C)=O)c1COC(C)=O>>CC(=O)Nc1cccc(NC(C)=O)c1CO,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20130059834A1,CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3n[nH]c4ccc(OC(F)F)cc34)nc12.CC(C)(C)OC(=O)N1CCC(Br)CC1>>CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C4CCN(C(=O)OC(C)(C)C)CC4)c4ccc(OC(F)F)cc34)nc12,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150119393A1,CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@H](Oc3nc4cc(Cl)c(-c5ccc([C@@H]6CC[C@H](N)CC6)cc5)nc4n3COCC[Si](C)(C)C)CO[C@H]12.O=C(Cl)OC1CCCC1>>CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@H](Oc3nc4cc(Cl)c(-c5ccc([C@H]6CC[C@@H](NC(=O)OC7CCCC7)CC6)cc5)nc4n3COCC[Si](C)(C)C)CO[C@H]12,,ClCCl,,CCN(CC)CC,,val
US05428043,C=CC(=O)OCC.CCOC(=O)c1cc2ccccc2[nH]1>>CCOC(=O)C1Cn2c(cc3ccccc32)C1=O,,Cc1ccccc1,,[H-].[Na+],,val
US20150119380A1,CCOC(=O)CC(=O)CCl.Nc1ccc(Cl)cn1>>CCOC(=O)Cc1cn2cc(Cl)ccc2n1,,CCO,,,,val
US20100298347A1,CCOC(=O)c1cc(-c2csc(S(C)(=O)=O)c2)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2c1>>CS(=O)(=O)c1cc(-c2cc(C(=O)O)cc3cc(-c4ccc(OC(F)(F)F)cc4)ccc23)cs1,,C1CCOC1,CO,[Li+].[OH-],,val
US20090176963A1,CC(O)C(=O)O.O=C(O)CC(O)C(=O)O>>CC(O)C(=O)O.O=C(O)O,,Cc1ccccc1,,,,val
US20100130492A1,CC(C)Cn1c(N2CCN[C@@H](C)C2)nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc21.C[C@H](O)CC(=O)O>>CC(C)Cn1c(N2CCN(C(=O)C[C@H](C)O)[C@@H](C)C2)nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc21,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US05221685,COc1cccc(C(=O)Cl)c1.N=C1NC(C(F)(F)F)(C(F)(F)F)C(=C(F)C(F)(F)F)S1>>COc1cccc(C(=O)NC2=NC(C(F)(F)F)(C(F)(F)F)C(=C(F)C(F)(F)F)S2)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20040063737A1,CCC(Sc1nc(Nc2ccc(S(N)(=O)=O)nc2)ncc1Br)C(C)=O>>CCC(Sc1nc(Nc2ccc(S(N)(=O)=O)nc2)ncc1Br)C(C)O,CC(=O)O,C1CCOC1,CO,[BH4-].[Na+],,val
US04960776,CN(C)CCN.CN(C)CCNC(=O)N1CCN(c2ccc(F)cc2)CC1.Clc1ccc(N2CCNCC2)cc1>>CN(C)CCNC(=O)N1CCN(c2ccc(Cl)cc2)CC1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US04087539,C=[N+]=[N-].O=C(c1ccco1)c1ccc2n1CCC2C(=O)O>>COC(=O)C1CCn2c(C(=O)c3ccco3)ccc21,,ClCCl,,,,val
US20140243310A1,C1CCOC1.CC(COC1CCc2nc(-c3ccc(OCC4CC4)c(Cl)c3)oc2C1)N=[N+]=[N-].O>>CC(=O)NC(C)COC1CCc2nc(-c3ccc(OCC4CC4)c(Cl)c3)oc2C1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090124604A1,ClI.Nc1c(C(=O)O)cccc1C(=O)O>>Nc1c(C(=O)O)cc(I)cc1C(=O)O,,CC(=O)O,,O,,val
US20110207967A1,BrP(Br)Br.COc1c(C)c(CC=C(C)CCC=C(C)CO)c(OC)c2ccccc12>>COc1c(C)c(CC=C(C)CCC=C(C)CBr)c(OC)c2ccccc12,,C1CCOC1,,,,val
US20060189629A1,CC(=O)Nc1cccc(N)c1.O=C(O)c1ccc(F)c([N+](=O)[O-])c1>>CC(=O)Nc1cccc(Nc2ccc(C(=O)O)cc2[N+](=O)[O-])c1,,CCO,,CCN(CC)CC,,val
US04835104,O=c1ccn([C@H]2C=C[C@@H](CO)O2)c(=O)[nH]1>>O=c1ccn([C@H]2CC[C@@H](CO)O2)c(=O)[nH]1,[Pd],CO,,[H][H],,val
US20160222014A1,CO.O=[N+]([O-])c1ccc(N2CCOCC2)cn1>>Nc1cccc(N2CCOCC2)c1,[Zn],,,[Cl-].[NH4+],,val
US20020091148A1,CCOC(=O)c1[nH]c2cc(Cl)cc(Cl)c2c1C>>Cc1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12,,CCO,O,Cl,[K+].[OH-],val
US20080262050A1,CCC1CCc2cc(O)ccc2C1.O=[N+]([O-])O>>CCC1CCc2cc(O)c([N+](=O)[O-])cc2C1,,CC(=O)O,,,,val
US20150051171A1,Cc1ccc(F)c2c1C(=O)C(=O)N2.OO>>Cc1ccc(F)c(N)c1C(=O)O,,O,,Cl,[Na+].[OH-],val
US20130023514A1,CC(C)(C)OC(=O)N[C@H]1CCC[C@@H](O)CC1>>N[C@@H]1CCC[C@H](O)CC1,,C1COCCO1,Cl,,,val
US20030083335A1,COc1ccc(Cl)cc1CO.O=S(Cl)Cl>>COc1ccc(Cl)cc1CCl,,ClCCl,,,,val
US20140127807A1,N.Nc1ccc(I)cc1.S=C(n1ccnc1)n1ccnc1>>NC(=S)Nc1ccc(I)cc1,,ClCCl,,,,val
US04618617,CC(c1ccc(-c2ccccc2)c(F)c1)c1nc(CC#N)no1.O.[OH-]>>CC(c1ccc(-c2ccccc2)c(F)c1)c1nc(CC(=O)O)no1,,O,,CO,,val
US04472310,CC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)C(=O)[C@H]5C[C@H]5[C@H]4[C@@H]3C=C[C@]2(O)C1>>C[C@]12CC[C@H]3[C@@H](C=C[C@]4(O)C[C@@H](O)CC[C@]34C)[C@@H]1[C@@H]1C[C@@H]1C2=O,,CCOCC,CO,O=C([O-])[O-].[K+].[K+],,val
US20130059834A1,CC(C)(C)c1ccc2c(I)n[nH]c2c1.CI>>Cn1nc(I)c2ccc(C(C)(C)C)cc21,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US05476860,CC1(C)CCC(C)(C)c2cc(C(=O)COc3ccc(C(=O)O)c(O)c3)ccc21.[Li]C>>CC1(C)CCC(C)(C)c2cc(C(C)(O)COc3ccc(C(=O)O)c(O)c3)ccc21,,C1CCOC1,,,,val
US20030199440A1,CC(C)(C)OC(=O)CN(CC(=O)OC(C)(C)C)S(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1.Cl>>Cl.N=C(N)Nc1ncc(Cl)c2ccc(S(=O)(=O)N(CC(=O)O)CC(=O)O)cc12,,C1COCCO1,,,,val
US20080009530A1,CC(C)Oc1cc(CCC(=O)O)n(Cc2ccc(Cl)cc2Cl)n1.CCCS(N)(=O)=O>>CCCS(=O)(=O)NC(=O)CCc1cc(OC(C)C)nn1Cc1ccc(Cl)cc1Cl,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20100267708A1,Clc1cc(NC2CCOCC2)c2[nH]c(C3=N[C@H](CCN4CCNCC4)CS3)cc2c1.O=C(CC(F)(F)F)ON1C(=O)CCC1=O>>O=C(CC(F)(F)F)N1CCN(CC[C@@H]2CSC(c3cc4cc(Cl)cc(NC5CCOCC5)c4[nH]3)=N2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20130267493A1,OC1COC1.Oc1ccc(Br)cc1>>Brc1ccc(OC2COC2)cc1,,C1CCOC1,CCOC(C)=O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090124682A1,CC(=O)C(=O)O.Nc1c(F)cc(Cl)cc1I>>O=C(O)c1cc2cc(Cl)cc(F)c2[nH]1,,CN(C)C=O,,C1CN2CCN1CC2,,val
US20090181963A1,CC(C)(C)OC(=O)N1CCC(n2nnc3c(N4CCOCC4)nc(-c4ccc(N)cc4)nc32)CC1.O=C=Nc1cccnc1>>CC(C)(C)OC(=O)N1CCC(n2nnc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5cccnc5)cc4)nc32)CC1,CN(C)c1ccncc1,ClCCl,,,,val
US20140121345A1,C=C(C)C(=O)OCCCCCCOc1ccc2cc(C=O)ccc2c1.O>>C=C(C)C(=O)OCCCCCCOc1ccc2cc(C(=O)O)ccc2c1,,CC(C)(C)O,O,CC=C(C)C,[Na+].[O-]Cl,val
US20060177603A1,CCCCCc1ccc(Br)c(O)c1F.Cc1ccc(Br)c(C(=O)O)c1F>>CCCCCc1ccc(Br)c(OC(=O)c2c(Br)ccc(C)c2F)c1F,CN(C)c1ccncc1,ClCCl,,O=C(O)C(=O)O,,val
US20050245741A1,COC(=O)c1ccc(NC(C)=O)c(O)c1.O=[N+]([O-])c1cccc(S(=O)(=O)OC[C@@H]2CO2)c1>>COC(=O)c1ccc(NC(C)=O)c(OC[C@@H]2CO2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020019424A1,CCOC(CC(OCC)OCC)OCC.Cc1ccc(S(=O)(=O)N2C(CCCC(=N)N)CCC2c2ccc(F)cc2)cc1>>Cc1ccc(S(=O)(=O)N2C(CCCc3ncccn3)CCC2c2ccc(F)cc2)cc1,,CN(C)C=O,,,,val
US20080269192A1,CC(CCO)n1c(CO)nc2cnc3cc(Br)ccc3c21>>CC1CCOCc2nc3cnc4cc(Br)ccc4c3n21,,Cl,,[Na+].[OH-],,val
US20040254217A1,O=[N+]([O-])c1ccc(CCCCn2ccnn2)cc1>>Nc1ccc(CCCCn2ccnn2)cc1,[Pd],C1CCOC1,CO,,,val
US20050256147A1,CC(C)(C)OC(=O)N1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(OC(=O)C(C)(C)C)cc13.CS(=O)(=O)Cl>>CC(C)(C)C(=O)Oc1ccc2c(c1)[C@@]13CCCC[C@H]1[C@@H](C2)N(S(C)(=O)=O)CC3,,ClCCl,,C1COCCO1,Cl,val
US20080242672A1,Fc1ccc(N2CCNCC2)c(F)c1.Nc1nc(Cl)c2ccn(CCBr)c2n1>>Nc1nc(Cl)c2ccn(CCN3CCN(c4ccc(F)cc4F)CC3)c2n1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090029863A1,CN=S(=O)(c1nc(Br)cs1)C(C)c1ccc(C(F)(F)F)nc1.Cc1ccc(B(O)O)cc1>>CN=S(=O)(c1nc(-c2ccc(C)cc2)cs1)C(C)c1ccc(C(F)(F)F)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20080267888A1,O=C1COCC(Cc2ccc(OCc3ccccc3)cc2)N1>>O=C1COCC(Cc2ccc(O)cc2)N1,[Pd],CO,,,,val
US20120289495A1,CC(C)(C)OC(=O)N1CC(=O)C1.Fc1ccc(-c2csc(C=P(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1>>CC(C)(C)OC(=O)N1CC(=Cc2nc(-c3ccc(F)cc3)cs2)C1,,C1CCOC1,,[H-].[Na+],,val
US20160272588A1,CCc1c(-c2ccc(O)cc2)cnc(N)c1Br.COc1ccc(B(O)O)c(F)c1>>CCc1c(-c2ccc(O)cc2)cnc(N)c1-c1ccc(OC)cc1F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20130096118A1,Cc1c(/C=C/[N+](=O)[O-])cccc1NC(=O)OCc1ccccc1.c1cc2ccc(N3CCOCC3)cc2[nH]1>>Cc1c(NC(=O)OCc2ccccc2)cccc1C(C[N+](=O)[O-])c1c[nH]c2cc(N3CCOCC3)ccc12,,C1CCOC1,,,,val
US20100016374A1,CC1CCCN1.Fc1ccc([C@H]2CO2)cc1>>CC1CCCN1C[C@@H](O)c1ccc(F)cc1,,CCO,,,,val
US06358973B1,COc1cccc(C(CN)C(C)C)c1.O=C(O)Cc1c(Cl)cncc1Cl>>COc1cccc(C(CNC(=O)Cc2c(Cl)cncc2Cl)C(C)C)c1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20030157671A1,COc1ccc([I+]c2ccc(OC)c(C(C)C)c2)cc1C(C)C.O=[N+]([O-])c1cc(Br)c(O)c(Br)c1>>CC(C)c1cc(Oc2c(Br)cc([N+](=O)[O-])cc2Br)ccc1O,[Cu],CCN(CC)CC,,,,val
US04911748,CI.O=C1NC(=Cc2ccccc2F)C(=O)N1c1cc(F)ccc1F>>CN1C(=O)N(c2cc(F)ccc2F)C(=O)C1=Cc1ccccc1F,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120101039A1,COC(=O)CCNC(=O)C1(c2ccc(CCCN[C@H](C)c3cccc4ccccc34)cc2)CCOCC1>>C[C@@H](NCCCc1ccc(C2(C(=O)NCCC(=O)O)CCOCC2)cc1)c1cccc2ccccc12,,CO,O,[Li+].[OH-],,val
US20020007045A1,CC(C)(C)C(=O)Cl.NCc1ccc(N)cc1>>CC(C)(C)C(=O)NCc1ccc(N)cc1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20100317582A1,COC(=O)c1ccc(OC2C=CC(O)C2)cc1.Cc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)c1ccc(O[C@@H]2C=C[C@H](Cl)C2)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20150252038A1,CC(C)(C)OC(=O)c1cc(C2CC2)c(CN2CCO[C@H](Cc3ccc(Cl)c(Cl)c3)C2)cc1F.Cl>>Cl.O=C(O)c1cc(C2CC2)c(CN2CCO[C@H](Cc3ccc(Cl)c(Cl)c3)C2)cc1F,,C1COCCO1,Cc1ccccc1,,,val
US20150336928A1,CC(=O)CC1(O)C(=O)N(C2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21>>CC(O)CC1(O)C(=O)N(C2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21,,CO,,[BH4-].[Na+],,val
US20030096848A1,N=C(N)n1cccn1.NC(=O)c1nnsc1Nc1ccccc1>>N=C(N)NCc1nnsc1Nc1ccccc1,,c1ccncc1,,CCN(C(C)C)C(C)C,Cl,val
US20030055085A1,CCI.CCOC(C)=O.N#Cc1cc(-c2nc(-c3ccc(F)cn3)no2)cc([N+](=O)[O-])c1>>CCN(CC)c1cc(C#N)cc(-c2nc(-c3ccc(F)cn3)no2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110046133A1,Cc1ccccc1C=O.Nc1ccc(C(=O)Nc2cccc(Cl)c2)cc1N>>Cc1ccccc1-c1nc2ccc(C(=O)Nc3cccc(Cl)c3)cc2[nH]1,,CO,,,,val
US20090298807A1,CC(C)(C)OC(=O)N(CCCCCCCCCN1CCC2(CC1)CN(C(=O)C(F)(F)F)CCO2)C[C@H](O)c1ccc(O)c2[nH]c(=O)sc12>>CC(C)(C)OC(=O)N(CCCCCCCCCN1CCC2(CC1)CNCCO2)C[C@H](O)c1ccc(O)c2[nH]c(=O)sc12,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20090264445A1,CCOC(=O)/C=C(\C)Oc1ccccc1OCc1ccccc1.O=C1CCC(=O)N1Br>>CCOC(=O)/C=C(\CBr)Oc1ccccc1OCc1ccccc1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US06376665B1,CNC(=O)CC(C(=O)N(C)[C@H](C)C(=O)OC)c1ccc(OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1>>CNC(=O)CC(C(=O)N(C)[C@H](C)C(=O)O)c1ccc(OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1,,CO,,[Li+].[OH-],,val
US20120157427A1,Clc1ncc(Cl)c(Cl)n1.OC1CCOCC1>>Clc1ncc(Cl)c(OC2CCOCC2)n1,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20160229837A1,CCC1CN(C(=O)OC(C)(C)C)CCC1Nc1nc(Nc2ccc3c(C)n(C)nc3c2)ncc1Cl>>CCC1CNCCC1Nc1nc(Nc2ccc3c(C)n(C)nc3c2)ncc1Cl,,CCOC(C)=O,ClCCl,Cl,,val
US05436247,CCCOC(=O)CC(C)=O.COc1ccc(C(=O)c2cc(OC)c(OC)cc2N)cc1OC>>CCCOC(=O)c1c(C)nc2cc(OC)c(OC)cc2c1-c1ccc(OC)c(OC)c1,,CC(=O)O,,O=S(=O)(O)O,,val
US05486466,C[C@H](O)CC(=O)OC(C)(C)C.O=C(Cl)OCc1ccc([N+](=O)[O-])cc1>>C[C@@H](CC(=O)OC(C)(C)C)OC(=O)OCc1ccc([N+](=O)[O-])cc1,CN(C)c1ccncc1,ClCCl,,,,val
US05919965,CCOC(=O)C(=O)c1csc(N)n1>>Nc1nc(C(O)CO)cs1,,C1CCOC1,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20100298340A1,COC(=O)c1ccc(C2OC2(C)[N+](=O)[O-])cc1.N=C(N)NC(N)=S>>COC(=O)c1ccc(-c2sc(NC(=N)N)nc2C)cc1,,CCO,,,,val
US20070244162A1,CC1SC(c2cccc(Cl)c2)=C(C(=O)c2cccnc2)C1(C)O>>Cc1sc(-c2cccc(Cl)c2)c(C(=O)c2cccnc2)c1C,,Cc1ccccc1,,CC(=O)OC(C)=O,,val
US20120238564A1,CN.Clc1nccn2c(Br)cnc12>>CNc1nccn2c(Br)cnc12,,CCO,,,,val
US06054448,COC(=O)[C@@H]1C[C@H](C(Cc2c3ccccc3cc3ccccc23)(C(=O)O)C(=O)OC)C1.[N-]=[N+]=NP(=O)(Oc1ccccc1)Oc1ccccc1>>NC(Cc1c2ccccc2cc2ccccc12)(C(=O)O)[C@H]1C[C@@H](C(=O)O)C1,,Cc1ccccc1,,CCN(CC)CC,,val
US04395406,CCOC(=O)CCl.O=c1[nH]cc(F)c(=S)[nH]1>>CCOC(=O)CSc1nc(=O)[nH]cc1F,,CCO,,[Na],,val
US20100234351A1,CC(O)COCCNC(=O)OC(C)(C)C.CI>>COC(C)COCCNC(=O)OC(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20040127574A1,Cc1cccc(CC(F)(F)C(F)F)c1.O=C1CCC(=O)N1Br>>FC(F)C(F)(F)Cc1cccc(CBr)c1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US04870075,CO/C=C(/C(=O)OC)c1ccccc1OCc1ccccc1>>CO/C=C(/C(=O)OC)c1ccccc1O,[Pd],CCOC(C)=O,,[H][H],,val
US20070187644A1,CCC(=O)Cl.CCCC1CCC(C2(c3cccc(O)c3)CCCCC2)CC1>>CCCC1CCC(C2(c3cccc(OC(=O)CC)c3)CCCCC2)CC1,,c1ccncc1,,Cl,O,val
US20040152750A1,CCOC(=O)CCNC(=O)c1ccc(N)cc1.O=Cc1ccc2c(c1)Cc1ccccc1-2>>CCOC(=O)CCNC(=O)c1ccc(NCc2ccc3c(c2)Cc2ccccc2-3)cc1,,CCO,,CC(=O)O,[BH3-]C#N.[Na+],val
US05202321,CCOC(=O)C(CC)CSC(C)=O>>CCOC(=O)C(CC)CS,,CO,,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US06506747B1,N#CCCCBr.O=C(O)c1ccc(O)cc1>>N#CCCCOc1ccc(C(=O)O)cc1,,CCO,,C,C[O-].[Na+],val
US20160075713A1,Cl.FC(F)(CN1CCC(Nc2ncnc3[nH]ccc23)CC1)c1ccccn1>>Cl.FC(F)(CN1CCC(Nc2ncnc3[nH]ccc23)CC1)c1ccccn1,,CO,,,,val
US20140088075A1,COc1ccc(CN(C)c2cc3c(cn2)cc(-c2cc(N)c(F)cc2Cl)c(=O)n3C(C)C)cc1>>CNc1cc2c(cn1)cc(-c1cc(N)c(F)cc1Cl)c(=O)n2C(C)C,,O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20120258953A1,CC(C)(C)OC(=O)N1CCOc2ccc(-c3cnc(N)c([N+](=O)[O-])c3)cc2C1.O=C(Cl)N1C2CCC1CC(O)(C(F)(F)F)C2>>Nc1ncc(-c2ccc3c(c2)CN(C(=O)N2C4CCC2CC(O)(C(F)(F)F)C4)CCO3)cc1[N+](=O)[O-],,C1CCOC1,CN1CCCC1=O,CCN(C(C)C)C(C)C,,val
US20080269244A1,CC(C)(C)OC(=O)N1CCC(Nc2ccc(N)cn2)CC1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(NC3CCN(C(=O)OC(C)(C)C)CC3)nc2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150141406A1,CCOC(=O)/C=C/c1cc(Br)c[nH]1.C[C@@H]1CCC[C@H]1O>>CCOC(=O)/C=C/c1cc(Br)cn1[C@@H]1CCC[C@@H]1C,,Cc1ccccc1,,CCCCP(=CC#N)(CCCC)CCCC,,val
US20110105459A1,CI.O=C(NC1CN(C(=O)N2CCCN(C3CCC3)CC2)C1)c1ccc(Cl)cc1>>CN(C(=O)c1ccc(Cl)cc1)C1CN(C(=O)N2CCCN(C3CCC3)CC2)C1,,C1CCOC1,,[H-].[Na+],,val
US20040152742A1,CC#N.CCN(CC)CC.O=[N+]([O-])c1ccc(Br)c(Cl)c1>>CCN(CC)CC#Cc1ccc([N+](=O)[O-])cc1Cl,[Cu]I,,,,,val
US20100179148A1,CCOC(=O)Nc1cccc(Cn2nc(-c3cccc([N+](=O)[O-])c3)ccc2=O)c1>>CCOC(=O)Nc1cccc(Cn2nc(-c3cccc(N)c3)ccc2=O)c1,[Ni],C1CCOC1,,,,val
US20110207777A1,CO[C@H]1CC[C@@H](N2CCC(Nc3cc(C)cc(F)c3[N+](=O)[O-])CC2)CC1>>CO[C@@H]1CC[C@H](N2CCC(Nc3cc(C)cc(F)c3N)CC2)CC1,[Ni],CCO,,NN,O,val
US20090137610A1,COc1cccc(C2CCC3(CC2)OCCO3)c1>>COc1cccc(C2CCC(=O)CC2)c1,,CC(C)=O,,Cl,,val
US20090275578A1,COC(=O)c1ccccc1CBr.NCCCc1ccc(C(F)(F)F)cc1>>O=C1c2ccccc2CN1CCCc1ccc(C(F)(F)F)cc1,,CCCCCC,Cc1ccccc1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20150057268A1,CC(C)CC1(c2ccccc2)OC(=O)C2=C1CN(C(=O)/C=C/c1ccccc1[N+](=O)[O-])CC2>>CC(C)CC1(c2ccccc2)OC(=O)C2=C1CN(C(=O)CCc1ccccc1N)CC2,[Pd],CCO,CCOC(C)=O,,,val
US06432993B1,Cc1ccc(Sc2ccc([N+](=O)[O-])c(N(C)C(=O)OC(C)(C)C)c2)cc1>>Cc1ccc(Sc2ccc(N)c(N(C)C(=O)OC(C)(C)C)c2)cc1,[Pd],CO,,,,val
US20050075342A1,COCC(=O)OC.CS(C)(=O)=O>>COC(=O)CS(C)(=O)=O,,C1CCOC1,,[Li]CCCC,,val
US04431653,COC(OC)N(C)C.c1c[nH]c(CC2CCNCC2)n1>>COC(OC)N1CCC(Cc2ncc[nH]2)CC1,,CO,,,,val
US20150368246A1,Fc1cccc2c1cc1c3nc(Cl)ccc3ncn21>>Fc1cccc2c1cc1n2CNc2ccc(Cl)nc2-1,,C1CCOC1,CO,[BH4-].[Na+],[Cl-].[NH4+],val
US20040147612A1,CC(CNS(=O)(=O)C(C)C)c1ccc2cc(OCCN)ccc2c1.CN=C=O>>CNC(=O)NCCOc1ccc2cc(C(C)CNS(=O)(=O)C(C)C)ccc2c1,,C1CCOC1,,,,val
US20140235660A1,COc1ccc2c(Oc3ccc(/C=C/C(=O)OC(C)(C)C)cc3)c(-c3ccc(F)cc3C)sc2c1>>COc1ccc2c(Oc3ccc(/C=C/C(=O)O)cc3)c(-c3ccc(F)cc3C)sc2c1,,Cl,,C1COCCO1,,val
US20070213311A1,CCC(O)(C(=O)N1CCC2(C1)OC(=O)c1ccccc12)c1ccc(Br)cc1F.CI>>CCC(OC)(C(=O)N1CCC2(C1)OC(=O)c1ccccc12)c1ccc(Br)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US04826869,CCCCn1cccc1Cc1cccc(NC(N)=O)c1>>CCCCN1CCCC1Cc1cccc(NC(N)=O)c1,,CO,O,Cl,,val
US05547919,CC(=N)N.COC(=O)CC(C(=O)OC)C(=O)OC>>COC(=O)Cc1c(O)nc(C)nc1O,,CO,,Cl,C[O-].[Na+],val
US20120077799A1,CC(C)(C)OC(=O)Nc1ncccc1Br.O=C1CCC(c2ccccc2)CC1>>CC(C)(C)OC(=O)Nc1ncccc1C1(O)CCC(c2ccccc2)CC1,,C1CCOC1,,[Li]CCCC,,val
US04326055,CC(=O)c1cc2c(c(N)c1Cl)C(C)(C)CC2(C)C.O=S(=O)(O)O>>CC(=O)c1cc2c(c(O)c1Cl)C(C)(C)CC2(C)C,,O,,O=N[O-].[Na+],,val
US20080058331A1,O=C(CNc1ccccc1)Nc1ccc(Cl)c(Cl)c1.O=C(Cl)c1cccc(C(F)(F)F)c1>>O=C(CN(C(=O)c1cccc(C(F)(F)F)c1)c1ccccc1)Nc1ccc(Cl)c(Cl)c1,,C1CCOC1,,,,val
US20120245144A1,CC(C)OB(OC(C)C)OC(C)C.c1cnn(C2CCCCO2)c1>>OB(O)c1ccnn1C1CCCCO1,,C1CCOC1,,[Li]CCCC,,val
US06551682B1,NNc1nc(OCC(F)(F)F)c(Cl)c(OCC(F)(F)F)c1Cl.O=C1C(=O)c2ccccc2-c2ccccc21>>Oc1c(N=Nc2nc(OCC(F)(F)F)c(Cl)c(OCC(F)(F)F)c2Cl)c2ccccc2c2ccccc12,,CC(=O)O,,,,val
US06329381B1,BrBr.Nc1nc(NC2CCCCC2)nc2c1ncn2Cc1ccccc1>>Nc1nc(NC2CCCCC2)nc2c1nc(Br)n2Cc1ccccc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20020128270A1,CS(=O)(=O)Cl.Oc1ccc(-c2cccs2)cc1>>CS(=O)(=O)Oc1ccc(-c2cccs2)cc1,,CC#N,,CCN(CC)CC,,val
US04034040,CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)C(=O)Cl.NCCN(CCO)CCO>>CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)C(=O)NCCN(CCO)CCO,,c1ccccc1,,,,val
US20070225267A1,CCO[C@H]1CN(C(=O)OC(C)(C)C)C(CO[Si](C)(C)C(C)(C)C)CO1>>CCO[C@@H]1CN(C(=O)OC(C)(C)C)C(CO)CO1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04849441,CO.Cc1cc(C)c(N)c(C2OC(=O)c3ccccc32)c1>>COC1c2ccccc2C(=O)Nc2c(C)cc(C)cc21,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20130131035A1,CNC(=O)c1ccc(N)cc1.Clc1ccc(OC2CN(c3ccnc(Cl)n3)C2)c(Cl)c1>>CNC(=O)c1ccc(Nc2nccc(N3CC(Oc4ccc(Cl)cc4Cl)C3)n2)cc1,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050215577A1,COC(=O)c1ccc(-c2nnc(C(F)(C3Cc4[nH]c5ccc(Cl)cc5c4C3)S(=O)(=O)c3cccc(Br)c3)o2)cc1>>O=S(=O)(c1cccc(Br)c1)C(F)(c1nnc(-c2ccc(CO)cc2)o1)C1Cc2[nH]c3ccc(Cl)cc3c2C1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05086062,O=c1[nH]c2cc(F)c(NCC3=C(Cl)c4ccccc4OC3)cc2o1>>O=c1[nH]c2cc(F)c(NCC3COc4ccccc4C3)cc2o1,,CCN(CC)CC,,,,val
US20140371240A1,CI.Cn1nc(C(F)(F)C(F)(F)F)c(C(F)(F)F)c1C(=O)Nc1ccc(F)c(C#N)c1F>>CN(C(=O)c1c(C(F)(F)F)c(C(F)(F)C(F)(F)F)nn1C)c1ccc(F)c(C#N)c1F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110136764A1,CCN(CC)S(F)(F)F.CCOP(=O)(OCC)C(O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccccc3C(=O)NC)n2)cc1>>CCOP(=O)(OCC)C(F)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccccc3C(=O)NC)n2)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US05972552,BrP(Br)Br.COC1CCC(CO)CC1>>COC1CCC(CBr)CC1,,ClC(Cl)(Cl)Cl,,,,val
US20080064740A1,CCOC(=O)CS/C(C)=C1\C(=O)C[C@@H]2[C@H]1C2(C)C>>CCOC(=O)c1sc(C)c2c1C[C@@H]1[C@H]2C1(C)C,,[Na+],[OH-],CCO,,val
US20110076214A1,CN(C)c1ccc(C=O)cc1.O=[N+]([O-])c1ccccc1>>CN(C)c1ccc(C=C[N+](=O)[O-])cc1,,CO,,CN,,val
US20100286120A1,CC(Cl)OC(=O)Cl.Clc1ccccc1Oc1ccc2c(n1)OCCN(Cc1ccccc1)C2>>Cl.Clc1ccccc1Oc1ccc2c(n1)OCCNC2,,CC(Cl)Cl,,,,val
US20110092513A1,CCOc1ncccc1C1(O)C(=O)Nc2cc(F)c(C#N)cc21.O=S(Cl)Cl>>CCOc1ncccc1C1(Cl)C(=O)Nc2cc(F)c(C#N)cc21,,ClCCl,,c1ccncc1,,val
US20140045872A1,CCn1cc(C=C(C)[N+](=O)[O-])c2ccccc21>>CCn1cc(CC(C)N)c2ccccc21,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05589474,COc1ccc2c(c1)S(=O)(=O)c1ccccc1C(=O)N2.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>COc1ccc2c(c1)S(=O)(=O)c1ccccc1C(=S)N2,,c1ccncc1,,,,val
US20090286985A1,BrBr.c1cncc(-c2c3ccccc3cc3ccccc23)c1>>Brc1c2ccccc2c(-c2cccnc2)c2ccccc12,,ClC(Cl)(Cl)Cl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20100069388A1,NOC1CCCCO1.O=C(O)/C=C/c1cnc(NCCOc2ccccc2)cn1>>O=C(/C=C/c1cnc(NCCOc2ccccc2)cn1)NOC1CCCCO1,,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US05426226,CCCN(CCC)C1CCc2cccc(C(=O)CC)c2C1.NO>>CCCN(CCC)C1CCc2cccc(C(CC)=NO)c2C1,,CO,O,Cl,,val
US20100197681A1,NC1CC1.Nc1nc2cc(C(F)(F)F)cc(Cl)n2n1>>Nc1nc2cc(C(F)(F)F)cc(NC3CC3)n2n1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20140162999A1,CC(C)(C)OC(=O)N1CCC(Oc2ncncc2N)C1.O=C(O)c1csc(-c2c(F)cccc2F)n1>>CC(C)(C)OC(=O)N1CCC(Oc2ncncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05102914,CS(=O)(=O)Nc1ccc(C(=O)CBr)cc1.c1ccc(CNCc2ccccc2)cc1>>CS(=O)(=O)Nc1ccc(C(=O)CN(Cc2ccccc2)Cc2ccccc2)cc1,,CC(C)=O,,,,val
US20110064892A1,CCCCCCCCC#Cc1cc(O[Si](C)(C)C(C)(C)C)ccc1-c1ccc(O[Si](C)(C)C(C)(C)C)cc1C#CCCCCCCCC>>CCCCCCCCc1cc2cc(O[Si](C)(C)C(C)(C)C)cc3c(CCCCCCCC)cc4cc(O[Si](C)(C)C(C)(C)C)cc1c4c23,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,,val
US05998653,CCOC(=O)c1ccc(F)c(Cl)c1N(CC)S(C)(=O)=O.CS>>CCOC(=O)c1ccc(SC)c(Cl)c1N(CC)S(C)(=O)=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090270436A1,COC(=O)c1cc(O)cc(C(=O)OC)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1cc(OS(=O)(=O)C(F)(F)F)cc(C(=O)OC)c1,,ClC(Cl)Cl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20070037807A1,CS(=O)(=O)Cl.Cc1ccc(-c2c(CN)c(C)nc(CC(C)C)c2CNC(=O)OC(C)(C)C)cc1>>Cc1ccc(-c2c(CNS(C)(=O)=O)c(C)nc(CC(C)C)c2CNC(=O)OC(C)(C)C)cc1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20030149001A1,CCc1cc2cnc(S(C)(=O)=O)nc2n(C2CCCC2)c1=O.Nc1ccc(N2CCC(O)CC2)cn1>>CCc1cc2cnc(Nc3ccc(N4CCC(O)CC4)cn3)nc2n(C2CCCC2)c1=O,,ClCCl,,,,val
US20120225854A1,O=S(=O)(c1ccc(N=C(c2ccccc2)c2ccccc2)s1)N1CCN[C@@H](CC2CCOCC2)C1.OC(c1cnc(Cl)nc1)(C(F)(F)F)C(F)(F)F>>Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cn3)[C@@H](CC3CCOCC3)C2)s1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20030158163A1,COC(=O)[C@@]1(OC(=O)c2ccc(OC(C)=O)o2)[C@H](C)CC2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]34O[C@H]4C[C@@]21C>>COC(=O)[C@@]1(OC(=O)c2ccc(O)o2)[C@H](C)CC2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]34O[C@H]4C[C@@]21C,,CO,,[Na+].[OH-],,val
US20110183954A1,CC(N)c1ncc(F)cc1F.Cn1cnc(Nc2nc(Cl)nc(Cl)n2)c1>>CC(Nc1nc(Cl)nc(Nc2cn(C)cn2)n1)c1ncc(F)cc1F,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20150274702A1,COC(=O)c1ccc(CNC(=O)c2cc(C(=O)NCc3ccc(F)c(C)c3)ncn2)cc1>>Cc1cc(CNC(=O)c2cc(C(=O)NCc3ccc(C(=O)O)cc3)ncn2)ccc1F,,C1CCOC1,,Cl,[K+].[OH-],val
US05318966,COc1cccc2c1CC[C@H]1[C@@H]2CC(=O)N1CCN1CCCCC1>>COc1cccc2c1CC[C@H]1[C@@H]2CCN1CCN1CCCCC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20020068733A1,N#CN.S=C1[N-]C=CC1Cc1ccc(Cl)nc1>>N#CN=C1NCCC1Cc1ccc(Cl)nc1,,CCO,,,,val
US20150353553A1,CCOc1ccc(C)cc1C(=O)N(Cc1ccc(Cl)cc1)c1c(N)n(C)c(=O)[nH]c1=O>>CCOc1ccc(C)cc1-c1nc2c(c(=O)[nH]c(=O)n2C)n1Cc1ccc(Cl)cc1,,CCO,,[Na+].[OH-],,val
US05849912,CCOC(=O)C(C)C(=O)OCC.O=C(Cl)c1cc([N+](=O)[O-])cc(Br)c1Cl>>CCOC(=O)C(C)(C(=O)OCC)C(=O)c1cc([N+](=O)[O-])cc(Br)c1Cl,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20120190680A1,Nc1cn(-c2ncccn2)c2cccc(Cl)c12.O=C(O)CC12CC3CC(CC(C3)C1)C2>>O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cn(-c2ncccn2)c2cccc(Cl)c12,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20150368254A1,CCOC(=O)CN1CC2(CCCN2C(=O)OCc2ccccc2)C1=O>>CCOC(=O)CN1CC2(CCCN2)C1=O,[Pd],CO,,,,val
US20030232827A1,COCC(=O)Cl.OCCCBr>>COCC(=O)OCCCBr,,ClCCl,,CCN(CC)CC,,val
US20110281842A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1ccc2c(c1)c(Br)cn2C(=O)OC(C)(C)C>>COc1ccc2c(c1)c(B1OC(C)(C)C(C)(C)O1)cn2C(=O)OC(C)(C)C,,CS(C)=O,,CC(=O)[O-].[K+],,val
US20160115119A1,N[C@@H]1CCc2c(F)cc(Cl)cc21.O=C(O)c1cnc2n1CCN(C(=O)OCc1ccccc1)C2.O=Cc1ccccc1.[C-]#[N+]C1=CCC(c2ccccc2)CC1>>NC(=O)[C@@H](c1ccccc1)N(C(=O)c1cnc2n1CCN(C(=O)OCc1ccccc1)C2)[C@@H]1CCc2c(F)cc(Cl)cc21,,CCN(CC)CC,,CO,Cl,val
US20030064991A1,COC[C@@H]1CCCN1.Cc1[nH]c2ccc(CCOS(C)(=O)=O)cc2c1C(=O)OCc1ccccc1>>Nc1cc2ccccc2[nH]1,,C1COCCO1,,,,val
US20120114765A1,CCOC(=O)c1cc([N+](=O)[O-])c(Cl)s1.Sc1cccc(Cl)c1Cl>>CCOC(=O)c1cc([N+](=O)[O-])c(Sc2cccc(Cl)c2Cl)s1,,CCO,O,[Na],,val
US20140275027A1,COc1ccc(F)cc1-c1ccnc2c1ccn2S(=O)(=O)c1ccccc1.O=C1CCOCC1.[Li]CCCC>>COc1ccc(F)cc1-c1ccnc2c1cc(C1(O)CCOCC1)n2S(=O)(=O)c1ccc(C)cc1,,C1CCOC1,,,,val
US05217976,CCc1cc(N)c(C(=O)OC)c(CC)n1>>CCc1cc(N)c(C(=O)O)c(CC)n1,,CO,,[Na+].[OH-],,val
US20050256158A1,COC(=O)c1ccc(COc2ccc(C(=O)N3c4ccccc4[C@H](N(C(C)=O)c4ccc(Cl)cc4)C[C@@H]3C)cc2)o1>>CC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2ccc(OCc3ccc(C(=O)O)o3)cc2)c2ccccc21,,C1CCOC1,,CCO,[Na+].[OH-],val
US20160168139A1,C=C(OCC)c1nccc(C)n1.O=C1CCC(=O)N1Cl>>Cc1ccnc(C(=O)CCl)n1,,C1CCOC1,,O,O=C([O-])O.[Na+],val
US20020143034A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=[N+]([O-])c1cccnc1Oc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1>>CC(C)(C)OC(=O)N(C[C@H](O)COc1ccccc1)[C@H](CO)Cc1ccc(Oc2ncccc2[N+](=O)[O-])cc1,,CCOC(C)=O,CN(C)C=O,O,,val
US04705854,CC(C)(C#N)c1ccc(Br)c([N+](=O)[O-])c1.Sc1ccccc1>>CC(C)(C#N)c1ccc(Sc2ccccc2)c([N+](=O)[O-])c1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20140088046A1,Brc1ccc(Br)nc1.O=C1COC1>>OC1(c2ccc(Br)cn2)COC1,,Cc1ccccc1,,[Li]CCCC,[Cl-].[NH4+],val
US06451816B1,O=C1c2ccccc2C(=O)N1CCCC1CCN(C(c2ccccc2)c2ccccc2)CC1>>NCCCC1CCN(C(c2ccccc2)c2ccccc2)CC1,,CCO,,NN,O,val
US20150164876A1,CCN(CC)c1ccc(NC(=O)c2cccc(C(=O)O)c2)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1.CNCCOCCOCCOCCC(=O)OC(C)(C)C>>CCN(CC)c1ccc(NC(=O)c2cccc(C(=O)N(C)CCOCCOCCOCCC(=O)OC(C)(C)C)c2)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06518257B1,CC(=O)NCc1cccc(Br)c1.CC(C)C(O)(c1ccc(B(O)O)cc1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CC(=O)NCc1cccc(-c2ccc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20070249642A1,Fc1cc(C(F)(F)F)ccc1[C@@]12CNC[C@@H]1C2.O=c1[nH]c(=O)n(CCCCl)cc1-c1cccs1>>Cl.O=c1[nH]c(=O)n(CCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3F)C2)cc1-c1cccs1,,CN(C)C=O,,O,,val
US20160145251A1,O=C(Nc1ccc(Cl)cc1)C1CN(C(=O)c2cccc(-c3ccco3)c2)CCN1.O=Cc1ccccc1>>O=C(Nc1ccc(Cl)cc1)C1CN(C(=O)c2cccc(-c3ccco3)c2)CCN1Cc1ccccc1,CC(=O)O,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040106614A1,COC(=O)C(N)C(=O)OC.O=C(Cl)c1ccc(Cl)cc1>>COC(=O)C(NC(=O)c1ccc(Cl)cc1)C(=O)OC,,ClCCl,,Cl,O,val
US20130150343A1,CN1CCC[C@H]1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(COS(C)(=O)=O)c4)c4ccccc43)cn12.CN1CCNCC1.ClCCl>>CN1CCN(Cc2cccc(-n3nc(C(C)(C)C)cc3NC(=O)N[C@H]3CC[C@@H](Oc4ccc5nnc([C@@H]6CCCN6C)n5c4)c4ccccc43)c2)CC1.O=CO,,ClCCl,,C1CCOC1,,val
US05885986,CCCN(CCC)Cc1coc(-c2ncn3c2CN(C)C(=O)c2sccc2-3)n1.Cl>>CCCN(CCC)Cc1coc(-c2ncn3c2CN(C)C(=O)c2sccc2-3)n1.Cl,,CCO,,,,val
US20160244409A1,CC1(C)C=CN(c2ccc(C(C)(C)C)cc2)CC1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC1(C)CCN(c2ccc(C(C)(C)C)cc2)C=C1C(=O)C(F)(F)F,,ClCCl,O,CCN(CC)CC,,val
US20060111375A1,BrCC1CO1.COc1cc2c(Oc3cc(C)c(C)nc3-c3cccnc3)ccnc2cc1O>>COc1cc2c(Oc3cc(C)c(C)nc3-c3cccnc3)ccnc2cc1OCC1CO1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150376174A1,CC(C)CBr.N#Cc1ccc(O)c(F)c1>>CC(C)COc1ccc(C#N)cc1F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160272584A1,CC(=O)OC(C)=O.COc1cccc(-c2cc(C(=O)Nc3ccc(-c4ccc(OC5CCN(C)CC5)cc4)c(N)c3)ccc2OC)c1>>COc1cccc(-c2cc(C(=O)Nc3ccc(-c4ccc(OC5CCN(C)CC5)cc4)c(NC(C)=O)c3)ccc2OC)c1,,c1ccncc1,,,,val
US20060135578A1,CC(=O)C(C)=NO.COC(=O)c1cc(C=O)ccc1OS(C)(=O)=O.Cl>>COC(=O)c1cc(-c2nc(CCl)c(C)o2)ccc1OS(C)(=O)=O,,CCOCC,,CCOC(C)=O,,val
US20030105280A1,COC(=O)c1ccc(CN(Cc2ccc(C(=O)OC)c(OCc3ccccc3)c2)C(=O)CCCCCNC(=O)OCc2ccccc2)cc1OCc1ccccc1>>COC(=O)c1ccc(CN(Cc2ccc(C(=O)OC)c(O)c2)C(=O)CCCCCN)cc1O,[Pd],CO,,Cl,,val
US20070072865A1,O=C(Nc1cccc2ncccc12)C(Cl)(Cl)Cl.O=C1OC(c2ccccc2)(c2ccccc2)C2CNCCN12>>O=C(Nc1cccc2ncccc12)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1,,CC#N,O,C1CCC2=NCCCN2CC1,,val
US04812573,COc1ccc2cnccc2c1>>Oc1ccc2cnccc2c1,,Br,,,,val
US05123951,CCCCN.CCOC(=O)CC(=O)Nc1ccc(Br)cc1C>>CCCCNC(=O)CC(=O)Nc1ccc(Br)cc1C,O,CCO,,,,val
US05589492,COC(=O)C(Cc1ccc(OCCN(C)c2nc3ccccc3o2)cc1)SC(C)C>>CC(C)SC(Cc1ccc(OCCN(C)c2nc3ccccc3o2)cc1)C(=O)O,,Cc1ccccc1,,,,val
US20150329523A1,C1COCCN1.COc1cc(SCCCCl)cc([N+](=O)[O-])c1>>COc1cc(SCCCN2CCOCC2)cc([N+](=O)[O-])c1,,CC#N,,[I-].[Na+],,val
US04021229,CS(=O)(=O)Cl.Nc1cc(Cl)c(Cl)cc1Cl>>CS(=O)(=O)Nc1cc(Cl)c(Cl)cc1Cl,,Cc1ccccc1C,,,,val
US20090030038A1,COc1ccc(N)c2c1C[C@@H](N1CCCC1)CC2.O=S(=O)(Cl)c1cccnc1>>COc1ccc(NS(=O)(=O)c2cccnc2)c2c1C[C@@H](N1CCCC1)CC2,,ClCCl,,c1ccncc1,,val
US20050277674A1,CN(C)C1(c2ccccc2)CCC(CNC(=O)N2CCCC(c3c[nH]c4ccccc34)C2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CN(C)C1(c2ccccc2)CCC(CNC(=O)N2CCCC(c3c[nH]c4ccccc34)C2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O,,CCO,,,,val
US20030055055A1,COCCOC(=O)c1ccc(Nc2cccc(N3CCN(CC(=O)OCc4ccccc4)CC3)c2)c([N+](=O)[O-])c1>>COCCOC(=O)c1ccc(Nc2cccc(N3CCN(CC(=O)O)CC3)c2)c(N)c1,[Pd],C1CCOC1,CN(C)C=O,O=C[O-].[NH4+],,val
US20100221799A1,CNC(=O)C(=O)c1ccccc1C>>CNC(=O)C(O)c1ccccc1C,,CO,,[BH4-].[Na+],,val
US20060030613A1,CC(C)(C)c1ccc(CNCCc2cc(F)cc(C(F)(F)F)c2)cc1.O=C(O)c1c(F)c(Cl)cc2cc[nH]c12>>CC(C)(C)c1ccc(CN(CCc2cc(F)cc(C(F)(F)F)c2)C(=O)c2c(F)c(Cl)cc3cc[nH]c23)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20030199542A1,CN.O=C(c1cccc(Cl)c1)c1cnccc1Cl>>CNc1ccncc1C(=O)c1cccc(Cl)c1,,O,,,,val
US20050107419A1,O=C(O)c1cnc(C2OCCO2)s1>>O=Cc1ncc(C(=O)O)s1,,Cl,,,,val
US20120184531A1,CNC(=O)c1cc(S(=O)(=O)c2ccccc2)cc2c3c(oc12)CCN(C(=O)OC(C)(C)C)C3.Cl>>CNC(=O)c1cc(S(=O)(=O)c2ccccc2)cc2c3c(oc12)CCNC3.Cl,,C1CCOC1,,,,val
US20080085890A1,CO/C=C1/C(=O)NC(=O)c2ccc(I)cc21.Nc1ccc(CN2CCCCC2)cc1>>O=C1NC(=O)c2ccc(I)cc2/C1=C/Nc1ccc(CN2CCCCC2)cc1,,CN(C)C=O,,CCOCC,,val
US20040077605A1,Nc1ccc([N+](=O)[O-])cc1I.[C-]#N>>N#Cc1ccc([N+](=O)[O-])cc1I,,Cl,O,O=N[O-].[Na+],,val
US20140031556A1,COc1c(Cl)ccc(B(O)O)c1F.O=C(O)c1cc(Cl)c(Cl)c(Cl)n1>>COc1c(Cl)ccc(-c2nc(C(=O)O)cc(Cl)c2Cl)c1F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,O,CCN(CC)CC,Cl,val
US20040058964A1,BrC(Br)(Br)Br.N#CCc1cccc(CO)c1>>N#CCc1cccc(CBr)c1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04814265,COS(=O)(=O)OC.Sc1nc2cccccc-2n1>>CSc1nc2cccccc-2n1,,CO,,[K+].[OH-],,val
US20090264650A1,O=C1C(C2(O)CCCCC2)CCN1Cc1ccccc1>>O=C1C(C2=CCCCC2)CCN1Cc1ccccc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120035159A1,CC1(C)CNCCCN1S(=O)(=O)c1ccc2cnccc2c1.Cl.ClCCl>>CC1(C)CNCCCN1S(=O)(=O)c1ccc2cnccc2c1.Cl.Cl,,ClCCl,,CCOCC,,val
US05084214,CC(C)(C)c1cc(S)cc(C(C)(C)C)c1O.O=C(O)CCCCCCCCCCCBr>>CC(C)(C)c1cc(SCCCCCCCCCCCC(=O)O)cc(C(C)(C)C)c1O,,CCO,O,CC(=O)O,[Na+].[OH-],val
US04563310,CCP(=O)(O)c1cc(Oc2ncc(Cl)cc2Cl)ccc1[N+](=O)[O-].COC(=O)CBr>>CCP(=O)(OCC(=O)OC)c1cc(Oc2ncc(Cl)cc2Cl)ccc1[N+](=O)[O-],,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090186909A1,CC(C)OB(OC(C)C)OC(C)C.COc1cc(O[Si](C)(C)C(C)(C)C)ccc1Br>>COc1cc(O[Si](C)(C)C(C)(C)C)ccc1B(O)O,,C1CCOC1,CCCCCC,Cl,[Li]CCCC,val
US20040023947A1,CI.CN(C)Cc1c[nH]c2cc(OCc3ccccc3)ccc12>>C[N+](C)(C)Cc1c[nH]c2cc(OCc3ccccc3)ccc12.[I-],,c1ccccc1,,,,val
US20080153810A1,CNC1(C(=O)OC(C)(C)C)NNc2ccc([N+](=O)[O-])cc21.CS(=O)(=O)Cl>>CN(C1(C(=O)OC(C)(C)C)NNc2ccc([N+](=O)[O-])cc21)S(C)(=O)=O,,O,c1ccncc1,,,val
US20090054407A1,C=Cc1ccc(N)c2c1CNC2=O>>CCc1ccc(N)c2c1CNC2=O,[Pd],CN(C)C=O,,[H][H],,val
US20110112158A1,Cc1cccc2c(O)noc12.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cc1cccc2c(OC(c3ccccc3)(c3ccccc3)c3ccccc3)noc12,,ClCCl,O,c1ccncc1,,val
US20150141427A1,CC1(C)OB(C2=CCOCC2)OC1(C)C.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(Br)c1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(C2=CCOCC2)c(Br)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20150111866A1,COC(=O)c1cc(C)c(-c2cnc(OC)c(-c3cnc(N4CC(F)C4)nc3CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)c2)c(C)c1.NN>>COc1ncc(-c2c(C)cc(C(=O)NN)cc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C,,CCO,,,,val
US20090069297A1,Clc1nnc(-c2ccccc2)c2ccccc12.NC(=O)c1cc2nccc(Oc3ccc(N)cc3)c2s1>>NC(=O)c1cc2nccc(Oc3ccc(Nc4nnc(-c5ccccc5)c5ccccc45)cc3)c2s1,,CC(C)(C)O,,,,val
US20030207879A1,CCC(Oc1cc(C(=O)O)on1)C(=O)O.CCCn1c(N)c(N)c(=O)n(CCC)c1=O>>CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)O)no3)nc2n(CCC)c1=O,,CO,,CCN=C=NCCCN(C)C,Cl,val
US20140206680A1,Cc1ccn2ncc(-c3nc(N[C@@H]4CCCC[C@@H]4NC(=O)OC(C)(C)C)c(F)c4c3C(=O)N(C(=O)OC(C)(C)C)C4)c2c1.Cl>>Cc1ccn2ncc(-c3nc(N[C@@H]4CCCC[C@@H]4N)c(F)c4c3C(=O)NC4)c2c1.Cl,,CC(C)O,,,,val
US20150175594A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1c(N)sc2ccccc12>>CCOC(=O)c1c(NC(=O)OC(C)(C)C)sc2ccccc12,CN(C)c1ccncc1,C1CCOC1,,CCOC(C)=O,[Cl-].[NH4+],val
US20050014744A1,CC(=O)CCl.COc1ccc2c(c1)S(=O)(=O)NC2=O>>COc1ccc2c(c1)S(=O)(=O)N(CC(C)=O)C2=O,,CN(C)C=O,,[H-].[Na+],,val
US05393730,NNc1c(Cl)cc(C(F)(F)F)cc1Cl.O=C(O)c1cccnc1C(=O)c1cccc(C(F)(F)F)c1>>O=C(c1cccc(C(F)(F)F)c1)c1ncccc1C(O)=NNc1c(Cl)cc(C(F)(F)F)cc1Cl,,Cc1ccccc1,,O,,val
US04195093,COC(=O)COc1cccc2c1CCCC2.O=C(Cl)c1cccs1>>COC(=O)COc1ccc(C(=O)c2cccs2)c2c1CCCC2,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20150087823A1,CCCCCCC/C=C/C(=O)N1CCC[C@H]1C(=O)OC>>CCCCCCC/C=C/C(=O)N1CCC[C@H]1C(=O)O,,CO,,[Na+].[OH-],,val
US07122548B2,Nc1nnc(Cc2ccc(O)cc2)n1N.O=CC(=O)c1ccc(F)cc1>>Oc1ccc(Cc2nnc3ncc(-c4ccc(F)cc4)nn23)cc1,,CC(=O)O,,,,val
US20040138215A1,CC#CCn1c(N2CCCC(NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(CC(=O)OC)c(=O)n2C>>CC#CCn1c(N2CCCC(NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(CC(=O)O)c(=O)n2C,,C1CCOC1,CO,[K+].[OH-],,val
US07001917B2,Cc1nn(-c2ccc(CCCl)cc2)c(C)c1-c1ccccc1.[N-]=[N+]=[N-]>>Cc1nn(-c2ccc(CCN=[N+]=[N-])cc2)c(C)c1-c1ccccc1,,CN(C)C=O,,O,,val
US20030186989A1,CC(C)(O)[C@@H]1CC=C(CN2C(=O)c3ccccc3C2=O)CC1>>CC(C)(O)[C@@H]1CC=C(CN)CC1,,CO,,NN,O,val
US20160194328A1,BrCCCBr.Nc1nccc2[nH]c(Sc3ccc(Cl)cc3Cl)nc12>>Nc1nccc2c1nc(Sc1ccc(Cl)cc1Cl)n2CCCBr,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070244117A1,O=C1c2ccccc2C(=O)N1OCc1cnc(Cl)s1>>NOCc1cnc(Cl)s1,,CCO,,NN,O,val
US06576656B1,Brc1cnc2ccccc2c1.CCN(CC)CCN1C(=O)C(=O)c2c(Br)cccc21>>CCN(CC)CCN1C(=O)C(O)(c2cnc3ccccc3c2)c2c(Br)cccc21,,CCOCC,,[Li]CCCC,[Cl-].[NH4+],val
US05523478,CCCCCCCCCCCCOS(=O)(=O)[O-].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>CCCCCCCCCCCCN(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,,O,,[Na+].[OH-],,val
US20160046596A1,CCCc1nccc(C=O)c1OCOC>>CCCc1nccc(C=O)c1O,,C1CCOC1,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090137580A1,Cn1ccc2ncnc(Oc3ccc(N)c(F)c3)c21.O=C=Nc1cc(C(F)(F)F)ccc1F>>Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)c(F)c3)c21,,C1CCOC1,O,CCN(CC)CC,,val
US07855292B2,N.O=C(O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1>>NC(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1,,O=S(Cl)Cl,,,,val
US20130281428A1,CC(C)(C)OC(=O)N1CCC(n2cc(B3OC(C)(C)C(C)(C)O3)cn2)CC1.Nc1ncc(Br)cc1-c1ccc(NC(=O)c2cn(CCF)cc(-c3ccc(F)cc3)c2=O)cc1>>CC(C)(C)OC(=O)N1CCC(n2cc(-c3cnc(N)c(-c4ccc(NC(=O)c5cn(CCF)cc(-c6ccc(F)cc6)c5=O)cc4)c3)cn2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20160096836A1,CCOC(=O)[C@@H]1CC2(CCN(c3cc(O[C@H](c4ccc(Cl)cc4-c4cccc(S(C)(=O)=O)c4)C(F)(F)F)nc(N)n3)CC2)CN1C(=O)OCc1ccccc1.Cc1ccc(B(O)O)cc1C>>CCOC(=O)[C@@H]1CC2(CCN(c3cc(O[C@H](c4ccc(-c5ccc(C)c(C)c5)cc4-c4cccc(S(C)(=O)=O)c4)C(F)(F)F)nc(N)n3)CC2)CN1C(=O)OCc1ccccc1,,C1COCCO1,,,,val
US20100158818A1,CC(C)(CC(=O)Cl)N=[N+]=[N-].CC1(C)CCNCC1>>CC1(C)CCN(C(=O)CC(C)(C)N=[N+]=[N-])CC1,,ClCCCl,,CCN(C(C)C)C(C)C,Cl,val
US05912246,CC(=O)c1ccc(N2CCNCC2)cc1.ClCc1cn2cc(Cl)ccc2n1>>CC(=O)c1ccc(N2CCN(Cc3cn4cc(Cl)ccc4n3)CC2)cc1,,C1CCOC1,,,,val
US04226773,CC(=O)N1CCN=C1Nc1ccnn1C.Cl>>Cl.Cn1nccc1NC1=NCCN1,,CO,,,,val
US20120302540A1,CC(C)(C)OC(=O)N1CCC2(C1)C(=O)NCC2c1ccccc1.CI>>CN1CC(c2ccccc2)C2(CCN(C(=O)OC(C)(C)C)C2)C1=O,,CN(C)C=O,O,[H-].[Na+],,val
US05457124,CCOC(=O)CCCOc1cccc(C#CCCCCOC2CCCCO2)c1C=CC(=O)OC>>CCOC(=O)CCCOc1cccc(CCCCCCOC2CCCCO2)c1CCC(=O)OC,[Pd],CCOC(C)=O,,,,val
US20020193414A1,CSCCN.O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(NCCCl)ccc1Cl>>CSCCNCCNc1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US06015774,COC(=O)CBr.Cn1c(C(F)(F)F)cnc(-c2cc(O)c(Cl)cc2F)c1=O>>COC(=O)COc1cc(-c2ncc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05112834,CCCCON=O.Cc1cn2cccc(O[C@@H]3c4ccccc4C[C@H]3O)c2n1>>Cc1nc2c(O[C@@H]3c4ccccc4C[C@H]3O)cccn2c1N=O,,C1CCOC1,,,,val
US04826533,Nc1cc(O)c(Cl)cc1F.O=C1OC(=O)C2CCCCC12>>O=C1C2=C(CCCC2)C(=O)N1c1cc(O)c(Cl)cc1F,,CC(=O)O,,,,val
US20120004381A1,CC(=O)Nc1ccc(N(C)C)cc1>>CCNc1ccc(N(C)C)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090311217A1,COc1ccc(N)cc1.O=C(CBr)c1ccccc1>>COc1ccc2[nH]c(-c3ccccc3)cc2c1,,CC(=O)N(C)C,ClCCl,,,val
US20100137417A1,CCC(Oc1cc(C)c(-c2ccc(C(C)(C)C)cc2)c(C)c1)c1ccc(C(=O)NCCC(=O)OC)s1>>CCC(Oc1cc(C)c(-c2ccc(C(C)(C)C)cc2)c(C)c1)c1ccc(C(=O)NCCC(=O)O)s1,,CO,,Cl,[Na+].[OH-],val
US20090318373A1,COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1O.ClCc1csc(CN2CCOCC2)n1>>COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(CN2CCOCC2)n1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US06420367B1,NNC(N)=S.O=c1[nH]c2ccccc2c(=O)o1>>NC(=S)NNC(=O)c1ccccc1N,,CN(C)C=O,,,,val
US20120129842A1,CCCO.Cc1nc(C)c(-c2csc(Nc3cc(C(N)=O)ccc3O)n2)s1>>CCCOc1ccc(C(N)=O)cc1Nc1nc(-c2sc(C)nc2C)cs1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110034464A1,CCS(=O)(=O)c1ccc(F)cc1CN.Cl.N#CC(C(N)=O)C1OC(=O)C(Cl)=C1Cl>>CCS(=O)(=O)c1ccc(F)cc1Cn1cc(Cl)cc(C(N)=O)c1=N.Cl,,CCO,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20130029987A1,O=C1CCC(=O)N1Br.O=C1c2ccccc2C(=O)N1[C@H]1C=CCCCC1>>O=C1c2ccccc2C(=O)N1[C@@H]1CCCC[C@H](O)[C@H]1Br,,ClC(Cl)Cl,,CCO,,val
US20070249607A1,CC(C)(C)OC(=O)N1CCC(CO)(c2ccccc2)CC1.N#Cc1ccc(-c2cc(Cl)cc(CBr)c2)cc1>>CC(C)(C)OC(=O)N1CCC(COCc2cc(Cl)cc(-c3ccc(C#N)cc3)c2)(c2ccccc2)CC1,,CN(C)C=O,O,[H-].[Na+],,val
US20100087429A1,CCNCC.O=C(O)c1cc(Br)ccc1O>>CCN(CC)C(=O)c1cc(Br)ccc1O,,CN(C)C=O,,ClCCCl,On1nnc2cccnc21,val
US04579862,CI.COc1ccc(COCC(Cn2ccnc2)OCCCCCCO)cc1>>COCCCCCCOC(COCc1ccc(OC)cc1)Cn1ccnc1,,C1CCOC1,,[H-].[Na+],,val
US20040053908A1,COc1cc2c(=S)cc[nH]c2cc1OCc1ccccc1.O=[N+]([O-])c1cnc(Br)s1>>COc1cc2c(Sc3ncc([N+](=O)[O-])s3)ccnc2cc1OCc1ccccc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20140142119A1,Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(N[C@H]4CCC[C@@H](N5CCCC5=O)C4)n3)c3cc(Cl)cnc32)cc1>>O=C1CCCN1[C@@H]1CCC[C@H](Nc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)C1,,C1COCCO1,CC#N,Cl,,val
US20030065005A1,O=P(Cl)(Cl)Cl.O=[N+]([O-])c1c(O)c2ccccc2n2nnnc12>>O=[N+]([O-])c1c(Cl)c2ccccc2n2nnnc12,,CN(C)C=O,,,,val
US20100160335A1,COCCC(=O)Nc1ccccc1O>>CCc1nc2c(OC)cccc2o1,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20070190041A1,Cc1ccc(N)c(F)c1.S=C(Cl)Cl>>Cc1ccc(N=C=S)c(F)c1,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US20090137595A1,Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)cc1.O=C(O)/C=C/c1ccccc1>>O=C(/C=C/c1ccccc1)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)cc1,,C1CCOC1,CC(=O)N(C)C,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20140303127A1,N#Cc1ccc2c(c1)nnn2CCCO.O=CO>>O=Cc1ccc2c(c1)nnn2CCCO,,O,,,,val
US20130237525A1,Brc1ccc2sc3ccccc3c2c1.CN(C)C=O>>O=Cc1ccc2sc3ccccc3c2c1,,CCOCC,,[Li]CCCC,[Cl-].[NH4+],val
US20160130254A1,CC(C)CO.O=C1CCCC(=O)C1>>CC(C)COC1=CC(=O)CCC1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US03979384,S.[N-]=[N+]=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](NC(=O)Cc3cccs3)[C@H]2SC1>>O=C(Cc1cccs1)N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CS)CS[C@H]12,,ClCCl,,,,val
US20030134854A1,COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(Br)c3)nc12.NCCc1ccccn1>>COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(NCCc4ccccn4)c3)nc12,,CN1CCCC1=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160108030A1,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOC(=O)c1nn(CC(=O)OC(C)(C)C)c2c1CCCC2>>CCOC(=O)c1nn(CC(=O)OC)c2c1[C@H]1C[C@H]1C2=O,,ClCCl,,,,val
US20090143354A1,Cc1ccc2nc(Cl)ccc2c1NC(=O)CC1CCCCC1.O[C@@H]1CCNC1>>Cc1ccc2nc(N3CC[C@@H](O)C3)ccc2c1NC(=O)CC1CCCCC1,,CC#N,,,,val
US20110105463A1,COC(=O)C1CCOc2cc(Oc3ccc(C(=O)NCCc4ccc(Cl)cc4)cc3)ccc21>>O=C(NCCc1ccc(Cl)cc1)c1ccc(Oc2ccc3c(c2)OCCC3C(=O)O)cc1,,C1CCOC1,ClCCl,CO,[Na+].[OH-],val
US04898863,CNC(=O)CCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc12.Cc1ccccc1S(N)(=O)=O>>CNC(=O)CCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc12,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20120165306A1,O=C(Nc1cc(-c2cncc(NCC3CCOCC3)n2)c(Cl)cn1)[C@H]1CN(C(=O)OCc2ccccc2)C[C@H]1F>>O=C(Nc1cc(-c2cncc(NCC3CCOCC3)n2)c(Cl)cn1)[C@H]1CNC[C@H]1F,[Pd],CO,,,,val
US20160185778A1,CC(C)(C)C(=O)Cl.CC(C)(C)OC(=O)N1CCC(=O)CC1>>CC(C)(C)OC(=O)N1CCC(=O)C(C(=O)C(C)(C)C)C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US04677216,CO[Si](OC)(OC)C(=CCCl)CCl>>C=CC(=C)[Si](OC)(OC)OC,[Zn],CCCCC,,C1CCOC1,,val
US04203918,CCOC(=O)C1C(C)(C)C12C(Cl)=C(Cl)c1ccccc12>>CCOC(=O)C1C(C)(C)C12C=C(Cl)c1ccccc12,,CC(C)(C)O,,O,CC(C)(C)[O-].[K+],val
US20110245257A1,COC(=O)c1cccc2nc([C@H](C)NC(=O)OCc3ccccc3)c(-c3cccnc3)n12>>COC(=O)c1cccc2nc([C@H](C)N)c(-c3cccnc3)n12,,O=C(O)C(F)(F)F,,CSC,,val
US20120142668A1,CC[C@@H](/C=C/C(=O)OC)NC(=O)[C@@H]1CCCCN1C(=O)OC(C)(C)C>>CC[C@@H](/C=C/C(=O)O)NC(=O)[C@@H]1CCCCN1C(=O)OC(C)(C)C,,C1CCOC1,CO,O,[Li+].[OH-],val
US20110130382A1,CC(C[C@H]1CN(Cc2ccccc2)CCN1C(=O)OC(C)(C)C)Oc1ccccc1Br>>CC(C[C@H]1CN(Cc2ccccc2)CCN1)Oc1ccccc1Br,,ClCCl,,Cl,,val
US20100249118A1,COc1ccc(C=O)cc1O.FC(F)(F)CI>>COc1ccc(C=O)cc1OCC(F)(F)F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090099161A1,COCc1nc2c(N)nc3cc(C=CS(C)(=O)=O)ccc3c2n1CC(C)(C)O>>COCc1nc2c(N)nc3cc(CCS(C)(=O)=O)ccc3c2n1CC(C)(C)O,[Pd],CCO,,CO,,val
US20160083370A1,CCOC(=O)c1sc(N2CCNCC2)nc1C.Cc1ccc(S(=O)(=O)OCCCc2c[nH]c3ccc(C#N)cc23)cc1>>CCOC(=O)c1sc(N2CCN(CCCc3c[nH]c4ccc(C#N)cc34)CC2)nc1C,,CC#N,,[I-].[K+],,val
US20110294776A1,CC(C)(C)OC(=O)N1CCc2ccc(-c3cc(-c4ccc5cn(Cc6ccccc6)nc5c4)c4c(N)ncnn34)cc2C1>>Nc1ncnn2c(-c3ccc4c(c3)CNCC4)cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150175623A1,COc1ccc(-c2csc3ncnc(Cl)c23)c(C)c1Cl.II>>COc1ccc(-c2c(I)sc3ncnc(Cl)c23)c(C)c1Cl,,C1CCOC1,O,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US05859025,Cc1ccc2cccc(O)c2n1.O=[N+]([O-])c1ccc(Cl)c(CBr)c1Cl>>Cc1ccc2cccc(OCc3c(Cl)ccc([N+](=O)[O-])c3Cl)c2n1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US06235771B1,CCI.Oc1ccc(Br)cc1Cl>>CCOc1ccc(Br)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05173484,CCNCC1(O)CCN(Cc2ccccc2)C1>>CCNCC1(O)CCNC1,[Pd],CO,,,,val
US20110071115A1,O=C1CC(C(F)(F)F)=NN1.O=Cc1cnn2ccc(Nc3cccc(Cl)c3)nc12>>O=C1NN=C(C(F)(F)F)C1=Cc1cnn2ccc(Nc3cccc(Cl)c3)nc12,,CCO,,C1CCNCC1,,val
US20050014950A1,COc1cc(CC[N+](=O)[O-])ccc1O>>COc1cc(CCN)ccc1O,[Ni],CCO,,NN,O,val
US20090048454A1,CCOC(=O)C12CCC(N)(CC1)CC2.NC(=O)[C@@H]1C[C@H](F)CN1C(=O)COS(=O)(=O)c1ccccc1>>CCOC(=O)C12CCC(NCC(=O)N3C[C@@H](F)C[C@H]3C(N)=O)(CC1)CC2,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US05082847,ClCC1CO1.O=C1CCc2c(O)ccc(OCc3ccccc3)c2N1>>O=C1CCc2c(OCC3CO3)ccc(OCc3ccccc3)c2N1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20100130446A1,O=C1CCC(=O)N1Cl.O=S(=O)(c1ccc(C(CC2CCOCC2)c2ccc(-c3ccccn3)[nH]2)cc1)C1CC1>>O=S(=O)(c1ccc(C(CC2CCOCC2)c2[nH]c(-c3ccccn3)cc2Cl)cc1)C1CC1,,C1CCOC1,CCOC(C)=O,,,val
US05025025,CCOC(=O)CCCC(O)CCC#N.Oc1cccnc1>>CCOC(=O)CCCC(CCC#N)Oc1cccnc1,,CCOCC,ClCCl,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150133510A1,Cl.O=C(Nc1ccccc1)Nc1ccc(CN(Cc2ccccc2)Cc2ccc(NC(=O)Nc3ccccc3)cc2)cc1>>O=C(Nc1ccccc1)Nc1ccc(C[NH+](Cc2ccccc2)Cc2ccc(NC(=O)Nc3ccccc3)cc2)cc1.[Cl-],,CCOCC,,,,val
US20070224603A1,O=C1c2ccccc2C(=O)N1CCCSc1ccc(O)cc1>>NCCCSc1ccc(O)cc1,,CCO,,NN,O,val
US20150087639A1,CC#N.CC(=O)O.CC(C)(O)Cc1ccc(Cl)c(F)c1>>CC(=O)NC(C)(C)Cc1ccc(Cl)c(F)c1,,CC(=O)O,,O=S(=O)(O)O,[Na+].[OH-],val
US20160002188A1,CC(C)(C)OC(=O)Nc1cc(-c2cccc(Br)c2)no1.CC1(C)OB(c2ccc(C(=O)N3CCN(C(=O)OCc4ccccc4)CC3)cc2)OC1(C)C>>CC(C)(C)OC(=O)Nc1cc(-c2cccc(-c3ccc(C(=O)N4CCN(C(=O)OCc5ccccc5)CC4)cc3)c2)no1,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080200494A1,Br.CC(C)c1cn2cc([N+](=O)[O-])ccc2n1>>Br.CC(C)c1cn2cc(N)ccc2n1,[Pd],CO,,[H][H],,val
US20090124598A1,COC(=O)c1cccc(C(=O)N(C)Cc2ccc(C(=O)N3CC4(C)CC3CC(C)(C)C4)cc2)c1>>CN(Cc1ccc(C(=O)N2CC3(C)CC2CC(C)(C)C3)cc1)C(=O)c1cccc(C(=O)O)c1,,CCO,,O,[Na+].[OH-],val
US20150210720A1,CC1(C)OC(=O)CC(=O)O1.C[C@@H](OCc1ccccc1)[C@@H](CC(=O)O)NC(=O)OC(C)(C)C>>C[C@@H](OCc1ccccc1)[C@H]1CC(=O)CC(=O)N1C(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US03965101,ClCOc1ccccc1Br.Nc1ncccn1>>Nc1nccc[n+]1COc1ccccc1Br.[Cl-],,Cc1ccccc1C,,,,val
US20040209865A1,C1CCNC1.ClCc1nc2cc(Br)ccc2o1>>Brc1ccc2oc(CN3CCCC3)nc2c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20110021537A1,CCOC(=O)Cl.C[C@H]1CN(C(=O)OC(C)(C)C)CCN1>>CCOC(=O)N1CCN(C(=O)OC(C)(C)C)C[C@@H]1C,,ClCCl,,CCN(CC)CC,,val
US20080171771A1,CC1(C)OB(c2cncc(F)c2)OC1(C)C.NC1=NC(c2ccncc2)(c2cccc(Br)c2)c2ccccc21>>NC1=NC(c2ccncc2)(c2cccc(-c3cncc(F)c3)c2)c2ccccc21,,CCO,O,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20120116075A1,Cc1ccc(C(=O)Cl)cc1.Cc1ccc(N)cc1NC(=O)/C=C/c1ccccn1>>Cc1ccc(C(=O)Nc2ccc(C)c(NC(=O)C=Cc3cccnc3)c2)cc1,,ClCCl,,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US04509972,CN(C)c1nc(N)nc2nccnc12.O=C=NS(=O)(=O)c1ccccc1Cl>>CN(C)c1nc(NC(=O)NS(=O)(=O)c2ccccc2Cl)nc2nccnc12,,CC#N,,,,val
US20100305096A1,CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1.O=S1(=O)CCN(C2CNC2)CC1>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CC(N4CCS(=O)(=O)CC4)C3)n(C)c2n1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05225423,CSC(=CC(=O)C(F)(F)F)SC.NCc1ccc(Cl)nc1>>CSC(=CC(=O)C(F)(F)F)NCc1ccc(Cl)nc1,,CCO,,,,val
US20090137804A1,CNc1cc(Nc2cccc(N(C)C)c2)ncn1.O=C=Nc1c(Cl)cccc1Cl>>CN(C)c1cccc(Nc2cc(N(C)C(=O)Nc3c(Cl)cccc3Cl)ncn2)c1,,CN(C)C=O,,,,val
US20100099665A1,CC(C)(C)OC(=O)N1CCN(Cc2c[nH]c(=O)c3ccc(Br)cc23)CC1.CC(C)(C)[Si](C)(C)OCC1(COS(C)(=O)=O)CCC1>>CC(C)(C)OC(=O)N1CCN(Cc2cn(CC3(CO[Si](C)(C)C(C)(C)C)CCC3)c(=O)c3ccc(Br)cc23)CC1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140005178A1,CCOC(=O)c1cccc(I)c1.NN>>NNC(=O)c1cccc(I)c1,,CCO,,O,,val
US05000946,CC(C)CCBr.CCOCC.N#Cc1cccnc1>>CC(C)CCC(=O)c1cccnc1,,[Cl-],[NH4+],Cl,,val
US20100197651A1,CC(C)I.O=c1c(O)cn(-c2cccc(C(F)(F)F)c2)nc1-c1ccnn1-c1ccccc1>>CC(C)Oc1cn(-c2cccc(C(F)(F)F)c2)nc(-c2ccnn2-c2ccccc2)c1=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05476661,CC(=O)Cl.CCCCCCCCCCCCCCCCNCC(O)CO>>CCCCCCCCCCCCCCCCN(CC(O)CO)C(C)=O,,ClC(Cl)Cl,,,,val
US20030055265A1,CCOC(=O)/C(=C/c1ccc(OCCc2nc(-c3ccccc3)oc2C)c2c1CCC2)OCC>>CCOC(=O)C(Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)c2c1CCC2)OCC,[Pd],C1CCOC1,,,,val
US04845284,CN(C)CCN.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1>>CN(C)CCNS(=O)(=O)c1cccc([N+](=O)[O-])c1.Cl,,C1CCOC1,,,,val
US04144248,CI.COC(=O)C(SC)c1ccc(N2C(=O)c3ccccc3C2=O)cc1>>COC(=O)C(C)(SC)c1ccc(N2C(=O)c3ccccc3C2=O)cc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20090143371A1,CN1CCC(N)CC1.Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1>>Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)NC2CCN(C)CC2)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20040097560A1,O=c1c(OCc2ccccc2)cccn1Cc1ccccc1>>O=c1c(O)cccn1Cc1ccccc1,[Pd],CO,,[H][H],,val
US20110237584A1,OCCCc1cccnc1>>O=CCCc1cccnc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US06248740B1,CCOC(=O)CN.Cc1c(C(=O)O)nc2ccc(Cl)nn12>>CCOC(=O)CNC(=O)c1nc2ccc(Cl)nn2c1C,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20060128783A1,CC(C)(C)OC(=O)NCCCOS(C)(=O)=O.Sc1ccc(Cl)cc1>>CC(C)(C)OC(=O)NCCCSc1ccc(Cl)cc1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20150246934A1,CN(C(=O)OC(C)(C)C)c1cc(F)cc2c1[nH]c1nc(Oc3cnc4ccnn4c3)nc(N3C[C@H]4C[C@@H]3C[C@H]4NC(=O)OC(C)(C)C)c12>>CNc1cc(F)cc2c1[nH]c1nc(Oc3cnc4ccnn4c3)nc(N3C[C@H]4C[C@@H]3C[C@H]4N)c12,,Cc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,val
US20150266857A1,CC(C)(C)OC(=O)N1CCC(Cn2cc3cc(-c4c[nH]c5cc(F)ccc45)ccc3n2)CC1>>Fc1ccc2c(-c3ccc4nn(CC5CCNCC5)cc4c3)c[nH]c2c1,,C1COCCO1,Cl,,,val
US20130245000A1,CC(C)C(N)=NO.CCOC(=O)c1ccc2c(ccn2-c2ccc(OC3CCN(C(=O)OC(C)(C)C)CC3)cn2)c1>>CC(C)c1noc(-c2ccc3c(ccn3-c3ccc(OC4CCN(C(=O)OC(C)(C)C)CC4)cn3)c2)n1,,C1CCOC1,,[H-].[Na+],,val
US20140107246A1,O=C(O)/C=C/C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O.OCC(O)CO>>O=C(O)/C=C/C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O.OCC(O)CO,,OCC(O)CO,,,,val
US06271261B1,NC(c1ccccc1)c1ccccc1.Nc1ccc([N+](=O)[O-])cc1O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(Nc1ccc([N+](=O)[O-])cc1O)NC(c1ccccc1)c1ccccc1,,CN(C)C=O,Cc1ccccc1,CCN(CC)CC,,val
US20100019229A1,CCCC[Sn](CCCC)(CCCC)c1cccs1.CCOP(=O)(OCC)c1csc(I)c1P(=O)(OCC)OCC>>CCOP(=O)(OCC)c1csc(-c2cccs2)c1P(=O)(OCC)OCC,Cl[Cu],CN(C)C=O,,Cl,,val
US20050214565A1,Brc1c2ccccc2c(-c2cc(-c3ccccc3)cc(-c3ccccc3)c2)c2ccccc12.OB(O)Oc1ccc(C=C(c2ccccc2)c2ccccc2)cc1>>C(=C(c1ccccc1)c1ccccc1)c1ccc(-c2c3ccccc3c(-c3cc(-c4ccccc4)cc(-c4ccccc4)c3)c3ccccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20100222339A1,CCC(CC)c1cc(C)nc2c(-c3sc(Br)nc3Br)c(C)nn12.O=CN1CCOCC1>>CCC(CC)c1cc(C)nc2c(-c3sc(C=O)nc3Br)c(C)nn12,,CCOCC,,C1CCOC1,[Li]CCCC,val
US06569849B1,CC(=O)C1c2ccccc2CCc2ccccc21.COC[Mg]Cl>>COCC(C)=C1c2ccccc2CCc2ccccc21,,C1CCOC1,,[Cl-].[NH4+],,val
US04051152,CC(=O)OC(C)=O.CCCCCC(C)C(C)c1cc(O)c2c(c1)OC(C)(C)C1=C2CCC1>>CCCCCC(C)C(C)c1cc(OC(C)=O)c2c(c1)OC(C)(C)C1=C2CCC1,,c1ccncc1,,,,val
US20080167377A1,CCOC(=O)Cc1ccc(NC(=O)c2c(Cl)ccc(O)c2F)cc1.Clc1cccc(CBr)c1>>CCOC(=O)Cc1ccc(NC(=O)c2c(Cl)ccc(OCc3cccc(Cl)c3)c2F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100197939A1,CC(C)(C)OC(=O)N1C[C@@H]([C@H]2COC(C)(C)O2)CC1=O>>CC(C)(C)OC(=O)N1C[C@@H]([C@H](O)CO)CC1=O,,CC(=O)O,,CCO,,val
US20100273793A1,CS/C(=N\C(=O)OC(C)(C)C)NC(=O)OC(C)(C)C.Nc1ccc(OCc2c(Cl)cccc2Cl)cc1N>>CC(C)(C)OC(=O)Nc1nc2ccc(OCc3c(Cl)cccc3Cl)cc2[nH]1,,CC(=O)O,CO,,,val
US08022062B2,CC(C)(C)[Si](C)(C)OCc1ccc(Br)cc1.O=Cc1cccnc1>>CC(C)(C)[Si](C)(C)OCc1ccc(C(O)c2cccnc2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20160222014A1,C[C@H](O)CN1CCN(c2ccc([N+](=O)[O-])cc2)C[C@H]1C>>C[C@H](O)CN1CCN(c2ccc(N)cc2)C[C@H]1C,[Pd],CO,,,,val
US20150266879A1,CC(C)(C)OC(=O)N[C@H](C(=O)N1c2ncccc2C[C@@H]1C(=O)Nc1ccccc1)C1CCCCC1>>N[C@H](C(=O)N1c2ncccc2C[C@@H]1C(=O)Nc1ccccc1)C1CCCCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06136974,CC(C)Cn1c(=O)n(C)c(=O)c2c(C#CCCCO)n(Cc3cccc4ccccc34)cc21>>CC(C)CN1CN(C)Cc2c1cn(Cc1cccc3ccccc13)c2CCCCCO,[Pd],CCO,,[H][H],,val
US20020143023A1,CC1=C(C(=O)O)C(c2cccc(Cl)c2)NC(=O)N1.CN1CCN(CCCN)CC1>>CC1=C(C(=O)NCCCN2CCN(C)CC2)C(c2cccc(Cl)c2)NC(=O)N1,,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20120245187A1,CC(C)(C)[Si](C)(C)Cl.CCN(CC)C(=O)Oc1ccc2[nH]ccc2c1>>CCN(CC)C(=O)Oc1ccc2c(ccn2[Si](C)(C)C(C)(C)C)c1,,C1CCOC1,,[H-].[Na+],,val
US20140350002A1,COc1ccc(N2CC3CCC2CC3=O)cc1.O=S(=O)(N(c1ccc(Cl)cn1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc(N2CC3CCC2C=C3OS(=O)(=O)C(F)(F)F)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20120010163A1,COC(=O)c1c(C)cc2c(c1O)[C@]1(O)C(=O)c3cc4c(c(O)c3C(=O)[C@]1(OC)[C@H](O)C2)C(=O)C=C(N[C@H]1O[C@@H](C)[C@H](OC)C(=NO)[C@H]1OC)C4=O.CON>>CO/N=C1/[C@@H](OC)[C@H](C)O[C@H](NC2=CC(=O)c3c(cc4c(c3O)C(=O)[C@]3(OC)[C@H](O)Cc5cc(C)c(C(=O)OC)c(O)c5[C@]3(O)C4=O)C2=O)[C@@H]1OC,,CO,,Cl,c1ccncc1,val
US20100160322A1,Clc1ccc(-c2ccccc2CN2CCNCC2)cc1.NS(=O)(=O)c1ccc(F)cc1F>>NS(=O)(=O)c1ccc(N2CCN(Cc3ccccc3-c3ccc(Cl)cc3)CC2)cc1F,,CCOC(C)=O,CS(C)=O,CCN(C(C)C)C(C)C,,val
US20150353553A1,C=CCCOc1ccc(C)cc1-c1nc2nc(Cl)nc(Cl)c2n1Cc1ccc(Cl)cc1.C[C@@H](N)C1CC1>>C=CCCOc1ccc(C)cc1-c1nc2nc(Cl)nc(N[C@H](C)C3CC3)c2n1Cc1ccc(Cl)cc1,,CCO,,,,val
US20120035214A1,CC(C)(C)OC(=O)N1CC[C@](O)(c2ccc(F)c(F)c2)[C@@H](c2cc(-c3c(Cl)cccc3Cl)on2)C1>>O[C@]1(c2ccc(F)c(F)c2)CCNC[C@@H]1c1cc(-c2c(Cl)cccc2Cl)on1,,ClCCl,,Cl,,val
US20150232443A1,CC(C)(C)NC(=O)C1CCN(C2CC3(CCN(C(=O)OC(C)(C)C)C3)C2)CC1.O=C(O)C(F)(F)F>>CC(C)(C)NC(=O)C1CCN(C2CC3(CCNC3)C2)CC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20030144288A1,C1COCCN1.COc1ccc(C2CCOCC2)c2sc(NC(=O)c3ccnc(Br)c3)nc12>>COc1ccc(C2CCOCC2)c2sc(NC(=O)c3ccnc(N4CCOCC4)c3)nc12,,CN1CCCC1=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080081815A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1c(C(=O)NNC(=O)C2CCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1>>Cc1c(-c2nnc(C3CCC3)s2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1,,C1COCCO1,,,,val
US20160016936A1,Cc1cc(-c2cn(CCOC3CCCCO3)c(C3(O[Si](C)(C)C(C)(C)C)CCN(C(=O)OC(C)(C)C)CC3)n2)ccc1F>>Cc1cc(-c2cn(CCO)c(C3(O[Si](C)(C)C(C)(C)C)CCN(C(=O)OC(C)(C)C)CC3)n2)ccc1F,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20040152696A1,O=C1c2ccccc2NC(C=C(c2ccccc2)c2ccccc2)N1CCN1CCCCC1>>O=c1c2ccccc2nc(C=C(c2ccccc2)c2ccccc2)n1CCN1CCCCC1,,ClC(Cl)Cl,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US04004912,CN1CCC(O)N(c2nnc(C3CC3)s2)C1=O.O=C(Cl)c1ccc(C(F)(F)F)cc1>>CN1CCC(OC(=O)c2ccc(C(F)(F)F)cc2)N(c2nnc(C3CC3)s2)C1=O,,c1ccccc1,,CCN(CC)CC,,val
US20110183953A1,CC(C)Oc1ccc(-c2nnc(-c3cccc4c3CC[C@H]4N(CC(=O)O)C(=O)OC(C)(C)C)s2)cc1C#N>>CC(C)Oc1ccc(-c2nnc(-c3cccc4c3CC[C@H]4NCC(=O)O)s2)cc1C#N,,C1COCCO1,,Cl,,val
US20090156600A1,CCO.Nc1cc([N+](=O)[O-])ccc1F>>CC(=O)Nc1cc(N)ccc1F,[Pd],,,,,val
US20090054352A1,CS(=O)(=O)Cl.O=C(Nc1c(O)cccc1C(=O)Nc1ccc(Cl)cn1)c1ccc(-c2cccn(CCN3CCNCC3)c2=O)cc1>>CS(=O)(=O)N1CCN(CCn2cccc(-c3ccc(C(=O)Nc4c(O)cccc4C(=O)Nc4ccc(Cl)cn4)cc3)c2=O)CC1.Cl,,c1ccncc1,,,,val
US20110092479A1,CCCNS(=O)(=O)Nc1ccc(F)c(C(=O)OC)c1F>>CCCNS(=O)(=O)Nc1ccc(F)c(C(=O)O)c1F,,CO,,C1CCOC1,[Na+].[OH-],val
US04067996,COC(=O)C(Oc1ccc(F)c(C(F)(F)F)c1)c1ccc(Cl)cc1>>O=C(O)C(Oc1ccc(F)c(C(F)(F)F)c1)c1ccc(Cl)cc1,,O,,Cl,[Na+].[OH-],val
US20120330024A1,CCOC(=O)CN1C(=O)CNC1=S.O=Cc1ccc(-c2cccc(I)c2)o1>>CCOC(=O)CN1C(=O)/C(=C/c2ccc(-c3cccc(I)c3)o2)NC1=S,,ClCCl,,C1CCNCC1,,val
US20040220235A1,COC(=O)c1cc([N+](=O)[O-])c(OC)cc1F.Nc1ccc(CCCCCc2ccc(Cl)c(Cl)c2)cc1>>COC(=O)c1cc([N+](=O)[O-])c(OC)cc1Nc1ccc(CCCCCc2ccc(Cl)c(Cl)c2)cc1,,C1CCOC1,,,,val
US20150148313A1,CCOC(=O)[C@H](CC(F)F)c1ccc([N+](=O)[O-])cc1CN(C)C(=O)OCc1ccccc1>>CCOC(=O)[C@H](CC(F)F)c1ccc(N)cc1CNC,[Pd],CO,,Cl,,val
US20130237535A1,O=C1COC2(CCNCC2)CN1C1CC1.O=S(=O)(Cl)c1ccc(Br)c(F)c1>>O=C1COC2(CCN(S(=O)(=O)c3ccc(Br)c(F)c3)CC2)CN1C1CC1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20110230460A1,CC(C)(N)C(=O)Nc1sccc1C(=O)c1ccccc1>>CC1(C)N=C(c2ccccc2)c2ccsc2NC1=O,,CCO,,CC(=O)O,,val
US04267188,CC1(CCO)CC(=O)N1.COC(C)(C)OC>>CC12CCOC(C)(C)N1C(=O)C2,,ClCCl,,CCOCC,FB(F)F,val
US20110201593A1,O=C1CCC2(CCC3(CC2)OCCO3)N1>>O=C1CCC2(CC1)CCC(=O)N2,,C1CCOC1,,Cl,,val
US20140350023A1,N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F.O=S(=O)(O)c1ccccc1>>N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F.O=S(=O)([O-])c1ccccc1,,CO,,,,val
US20060276433A1,CN(C)Cc1ccc(C=O)cc1.NNc1ccc(-c2cnco2)c(I)c1>>CN(C)Cc1ccc(C=NNc2ccc(-c3cnco3)c(I)c2)cc1,,CCO,,Cl,,val
US20110105568A1,NO.O=C(Cl)/C=C/c1ccn(S(=O)(=O)c2ccc(-c3ccccn3)s2)c1>>O=C(/C=C/c1ccn(S(=O)(=O)c2ccc(-c3ccccn3)s2)c1)NO,,O,,Cl,,val
US20140303127A1,C1=COCCC1.COc1cc(C#N)c(Cl)cc1CO>>COc1cc(C#N)c(Cl)cc1COC1CCCCO1,,C1CCOC1,ClCCl,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US06610707B1,NNC(N)=S.O=C(O)[C@@H]1CCCCN1S(=O)(=O)c1ccc(F)cc1>>NC(=S)NNC(=O)[C@@H]1CCCCN1S(=O)(=O)c1ccc(F)cc1,,C1CCOC1,C1COCCO1,O=C(n1ccnc1)n1ccnc1,,val
US20090105253A1,CCCc1c(C(=O)NC2CC2)nnn1-c1ccc(N)cc1.O=C(Cl)c1ccccc1>>CCCc1c(C(=O)NC2CC2)nnn1-c1ccc(NC(=O)c2ccccc2)cc1,,ClCCl,,,,val
US20080004297A1,Cc1nc(N(C)c2ccc(N(C)C)cc2)c2cc([N+](=O)[O-])ccc2n1>>Cc1nc(N(C)c2ccc(N(C)C)cc2)c2cc(N)ccc2n1,[Pd],CCOC(C)=O,CO,,,val
US20080076777A1,Nc1ccc(F)cc1N1CCN(C/C=C/c2ccc(Cl)cc2)CC1.O=C=NCCCl>>O=C1NCCN1c1ccc(F)cc1N1CCN(C/C=C/c2ccc(Cl)cc2)CC1,,C1CCOC1,,[H-].[Na+],,val
US20150232463A1,Cc1nc(C)c(CC(=O)O)s1>>Cc1nc(C)c(CCO)s1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140121231A1,CC(C)(OCc1ccccc1)C1CC(O)CCO1>>CC(C)(OCc1ccccc1)C1CC(=O)CCO1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20140315963A1,CCOC(=O)CBr.CN(Cc1nc2cc(Cl)c(Cl)cc2[nH]1)C(=O)OC(C)(C)C>>CCOC(=O)Cn1c(CN(C)C(=O)OC(C)(C)C)nc2cc(Cl)c(Cl)cc21,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090176778A1,CN.CNc1cn2cc(-c3ccoc3)cc(C(F)(F)F)c2n1.O=C=NCc1ccccc1>>O=C(NCc1ccccc1)NCc1cn2cc(-c3ccoc3)cc(C(F)(F)F)c2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US06809097B1,COCCOc1cc2nccc(Cl)c2cc1C#N.Cc1ccc(N)cc1O.Cl>>COCCOc1cc2nccc(Nc3ccc(C)c(O)c3)c2cc1C#N.Cl,,CC(C)O,,,,val
US20140200227A1,CC(C)(C)OC(=O)N[C@H]1CCCN(c2c([N+](=O)[O-])cnc3c2CCCN3C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N[C@H]1CCCN(c2c(N)cnc3c2CCCN3C(=O)OC(C)(C)C)C1,[Fe],O,,CC(=O)O,,val
US04147552,CCOc1ccc(C=O)cc1.COc1ccc2cc(C(C)=O)c(=O)oc2c1>>CCOc1ccc(C=CC(=O)c2cc3ccc(OC)cc3oc2=O)cc1,C1CCNCC1,CC#N,,,,val
US05403852,N#CCCCCCc1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)o1.[N-]=[N+]=[N-]>>Clc1ccc(-c2nc(CCCCCc3nnn[nH]3)oc2-c2ccc(Cl)cc2)cc1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20130059834A1,CI.COC(=O)c1ccc2[nH]nc(I)c2c1>>COC(=O)c1ccc2c(c1)c(I)nn2C,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20080306087A1,Clc1ccc(C(c2ccccc2)N2CCNCC2)cc1.O=C(Cl)c1cccc(F)c1>>O=C(c1cccc(F)c1)N1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1,CN(C)c1ccncc1,ClCCCl,,CCN(CC)CC,,val
US06252090B1,CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCN3C2CC2)cc1>>CC1(C)CCN(C2CC2)c2ccc(CCc3ccc(C(=O)O)cc3)cc21,,CCO,,[Na+].[OH-],,val
US20130096124A1,Cc1cc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)oc1CO>>Cc1cc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)oc1C=O,O=[Mn]=O,ClCCl,,,,val
US05981533,c1ccc(Cn2nc(Nc3ccccc3)c3c(Nc4ccccc4)ncnc32)cc1>>c1ccc(Nc2ncnc3[nH]nc(Nc4ccccc4)c23)cc1,,O,c1ccccc1,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20030125551A1,C=CC(=O)Cl.C=O.COc1ccc(O)cc1.NCCCO>>C1=Cc2ccccc2ON1,,Cc1ccccc1,O,CCN(CC)CC,,val
US04448694,CO[Si](CCCCl)(OC)OC.CO[Si](CCCNCCN)(OC)OC>>CO[Si](OC)(OC)C(CCNCCN)[Si](OC)(OC)OC,,CO,,,,val
US20020107252A1,CC(=O)Nc1sc(-c2ccc(C#N)cc2)cc1C#N.O=S(=O)(O)O>>N#Cc1ccc(-c2cc(C(N)=O)c(N)s2)cc1,,CCO,,,,val
US20160222005A1,CC(C)(C)OC(=O)N1CCC(c2cnc3[nH]c(-c4cnn(Cc5ccccc5)c4)nc3c2)CC1>>c1ccc(Cn2cc(-c3nc4cc(C5CCNCC5)cnc4[nH]3)cn2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05650428,CCOC(=O)Cc1ccc(NC(=O)C(Cn2ccnc2)NS(=O)(=O)c2ccc(F)cc2)cc1>>O=C(O)Cc1ccc(NC(=O)C(Cn2ccnc2)NS(=O)(=O)c2ccc(F)cc2)cc1,,CCO,,[Na+].[OH-],,val
US20160046618A1,COC(=O)[C@@]12SC(N)=N[C@](C)(c3cc(Br)ccc3F)[C@@H]1C2(F)F>>C[C@]1(c2cc(Br)ccc2F)N=C(N)S[C@]2(CO)[C@H]1C2(F)F,,C1CCOC1,,CO,[BH4-].[Li+],val
US20020040019A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.c1cc2cnc(N3CCOCC3)cc2[nH]1>>CC(C)(C)OC(=O)N1CC=C(c2c[nH]c3cc(N4CCOCC4)ncc23)CC1,,CO,,[K+].[OH-],,val
US20040142947A1,COc1ccc2c(c1)c(-c1cc3c(-c4cn(S(=O)(=O)c5ccc(C)cc5)c5ccc(OC)cc45)ncnc3n1S(=O)(=O)c1ccc(C)cc1)cn2C>>COc1ccc2[nH]cc(-c3ncnc4[nH]c(-c5cn(C)c6ccc(OC)cc56)cc34)c2c1,,CO,,[K+].[OH-],,val
US04968343,CC(Oc1ccc(Oc2cnc3cc(Cl)ccc3n2)cc1)C(=O)Cl.Nc1ccc(C(F)(F)F)cc1>>CC(Oc1ccc(Oc2cnc3cc(Cl)ccc3n2)cc1)C(=O)Nc1ccc(C(F)(F)F)cc1,,CC#N,,CCN(CC)CC,Cl,val
US20150366252A1,N=C(NO)c1c(N)cccc1OCC1(C(=O)NC2CCCC2)CCCNC1=O>>N=C(N)c1c(N)cccc1OCC1(C(=O)NC2CCCC2)CCCNC1=O,[Zn],CC(=O)O,CCOC(C)=O,,,val
US20050004133A1,CC(C)(C)c1ccc(C(=O)Cl)cc1.NCc1ccc2[nH]c(=O)[nH]c2c1>>CC(C)(C)c1ccc(C(=O)NCc2ccc3[nH]c(=O)[nH]c3c2)cc1,,CCN(CC)CC,CN(C)C=O,,,val
US06399773B1,COc1cc([N+](=O)[O-])ccc1Cl.c1c[nH]cn1>>COc1cc([N+](=O)[O-])ccc1-n1ccnc1,,CS(C)=O,,[K+].[OH-],,val
US20110098296A1,CI.Cc1cc[nH]c(=S)n1>>CSc1nccc(C)n1,,CCO,,O,[Na+].[OH-],val
US05021413,C1CCN(CC2CSCCN2)C1.CSc1ccc(CC(=O)Cl)cc1>>CSc1ccc(CC(=O)N2CCSCC2CN2CCCC2)cc1.Cl,,CCN(CC)CC,,,,val
US20140113901A1,CO.Cc1c(N)nnc(Cl)c1C>>COc1nnc(N)c(C)c1C,,CO,,C[O-].[Na+],,val
US08987474B2,CCO.CN(C)C=C1C(=O)Nc2ccc(S(=O)(=O)O)cc21.COC(=O)c1ccccc1N>>COC(=O)c1ccccc1NC=C1C(=O)Nc2ccc(S(=O)(=O)NC(C)C)cc21,,CCO,,CS(=O)(=O)O,,val
US20080234277A1,NCc1nc2ncncc2c(=O)[nH]1.O=C(Cl)CCc1ccccc1>>O=C(CCc1ccccc1)NCc1nc2ncncc2c(=O)[nH]1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20040171881A1,CCCC(=O)c1cc(C(=O)OC)ccc1O.NO>>CCC/C(=N\O)c1cc(C(=O)OC)ccc1O,,CCO,,Cl,c1ccncc1,val
US20120010183A1,CC(C)(C)OC(=O)OC(C)(C)C.O=C(O)c1ccc(F)cc1F>>CC(C)(C)OC(=O)c1ccc(F)cc1F,CN(C)c1ccncc1,CC(C)(C)O,,,,val
US20160168149A1,CN(C(=O)OC(C)(C)C)c1cccc(Nc2ncnc(N(Cc3ccccc3)Cc3ccccc3)c2Nc2ccc(Oc3ccccc3)cn2)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN(C(=O)OC(C)(C)C)c1cccc(-n2c(=O)n(-c3ccc(Oc4ccccc4)cn3)c3c(N(Cc4ccccc4)Cc4ccccc4)ncnc32)c1,,ClCCl,,,,val
US20140371205A1,CI.COc1cccc2c1C(=O)NC2(C)C>>COc1cccc2c1C(=O)N(C)C2(C)C,,C1CCOC1,,[H-].[Na+],,val
US06147087,CC(=O)CC(C)=O.O=Cc1ccc([N+](=O)[O-])cc1>>CC(=O)C(=Cc1ccc([N+](=O)[O-])cc1)C(C)=O,,CC(C)O,,C1CCNCC1,CC(=O)O,val
US04960776,NCCN1CCC1.O=C(n1ccnc1)n1ccnc1.c1ccc(N2CCNCC2)cc1>>O=C(NCCN1CCC1)N1CCN(c2ccccc2)CC1,,C1CCOC1,,,,val
US05643923,OC1CN2CCC1CC2.Oc1ccon1>>c1cc(OC2CN3CCC2CC3)no1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04636521,NCc1ccc2[nH]cc(CCN3C(=O)c4ccccc4C3=O)c2c1.O=S(=O)(Cl)c1ccccc1>>O=C1c2ccccc2C(=O)N1CCc1c[nH]c2ccc(CNS(=O)(=O)c3ccccc3)cc12,,O,c1ccncc1,,,val
US20100280011A1,CC(C)[Si](OCc1ccc(C(CNC(=O)c2ccccc2C(=O)O)C(=O)O)cc1)(C(C)C)C(C)C.Nc1ccc2cnccc2c1>>CC(C)[Si](OCc1ccc(C(CN2C(=O)c3ccccc3C2=O)C(=O)Nc2ccc3cnccc3c2)cc1)(C(C)C)C(C)C,CN(C)c1ccncc1,c1ccncc1,,ClCCCl,,val
US20040019059A1,C=CC(=O)Nc1ccc(C(=O)c2ccccc2)cc1.O=C1CC(=O)N(Cl)C1.O=Cc1cncnc1>>O=C(c1ccccc1)c1ccc(NC(=O)C2CC(c3cncnc3)=NO2)cc1,,c1ccncc1,,CCN(CC)CC,CN(C)C=O,val
US20060235029A1,CCN.CCN(CC)CCCNc1nc(-c2cc(C(=O)O)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1>>CCNC(=O)c1ccc(C)c(-c2nc(NCCCN(CC)CC)nc3c2ccc(=O)n3-c2c(F)cccc2F)c1,,C1CCOC1,ClCCl,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20130072470A1,CC[C@@H]1CNC[C@@H]1c1cnc2cnc3c(ccn3S(=O)(=O)c3ccc(C)cc3)n12.NC1CCC1.O=C(n1ccnc1)n1ccnc1>>CC[C@@H]1CN(C(=O)NC2CCC2)C[C@@H]1c1cnc2cnc3c(ccn3S(=O)(=O)c3ccc(C)cc3)n12,,CC#N,,,,val
US20130034504A1,C=C(C)CBr.CCOC(CCO)OCC>>C=C(C)COCCC(OCC)OCC,,C1CCOC1,,[H-].[Na+],,val
US05633248,N#CCBr.O=CC(c1ccccc1)c1ccccc1>>N#CCC(C=O)(c1ccccc1)c1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20050096306A1,CC(C)(C)OC(=O)NCCC(=O)C(=O)Nc1cnn(CCOC(c2ccccc2)(c2ccccc2)c2ccccc2)c1NC(c1ccccc1)(c1ccccc1)c1ccccc1.CCOP(=O)(CC#N)OCC>>CC(C)(C)OC(=O)NCC/C(=C\C#N)C(=O)Nc1cnn(CCOC(c2ccccc2)(c2ccccc2)c2ccccc2)c1NC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,O,[H-].[Na+],val
US20160264518A1,CCOP(=O)(CC(=O)OC(C)(C)C)OCC.O=Cc1ccccc1Br>>CC(C)(C)OC(=O)/C=C/c1ccccc1Br,,C1CCOC1,,O,[H-].[Na+],val
US20090176775A1,CC(C)(C)OC(=O)N1CCN(C(=O)N2CCC(c3cccnc3)C2)c2ccccc21>>O=C(N1CCC(c2cccnc2)C1)N1CCNc2ccccc21,,C1COCCO1,,Cl,,val
US20110082156A1,CC(C)(C)OC(=O)NCCSSCCN.Cc1cnc(C(=O)O)c[n+]1[O-]>>Cc1cnc(C(=O)NCCSSCCNC(=O)OC(C)(C)C)c[n+]1[O-],,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04411899,O=C1NC(=O)c2ccccc21.O=Cc1cccc(OCC(O)CCl)c1>>O=Cc1cccc(OCC(O)CN2C(=O)c3ccccc3C2=O)c1,,CCOCC,CN(C)C=O,[K],,val
US20140045906A1,CCc1cc(C(=O)O)on1.C[C@@](CO)(C[C@H](N)Cc1ccc(-c2cc(Cl)ccc2F)cc1)C(=O)O>>CCc1cc(C(=O)N[C@H](Cc2ccc(-c3cc(Cl)ccc3F)cc2)C[C@@](C)(CO)C(=O)O)on1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030092677A1,CC1(C)OC(=O)C=C(c2cccc(C#N)c2)O1.COc1ccccc1-c1ccc(NC(=O)OC(C)(C)C)c(N)c1>>COc1ccccc1-c1ccc2c(c1)NC(=O)CC(c1cccc(C#N)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040214841A1,COc1ccc(Cl)c(Nc2ncnc3cc(OCc4ccccc4)cc(OCCCN4CCCC4)c23)c1>>COc1ccc(Cl)c(Nc2ncnc3cc(O)cc(OCCCN4CCCC4)c23)c1,[Pd],C1CCOC1,,CCO,[H][H],val
US03976643,CNC(=N)Nc1c(Cl)cccc1Cl>>CNC(=N)Nc1c(Cl)cccc1Cl,,[Na+],[OH-],Cl,,val
US20120232056A1,COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N(C)Cc3ccccc3)nc2c1>>CN(Cc1ccccc1)c1nc2cc(C(=O)O)ccc2nc1-c1ccc(F)cc1,,CO,O,Cl,[Na+].[OH-],val
US20080125436A1,CI.Cn1c(S)nnc1-c1ccn(C)c(=O)c1>>CSc1nnc(-c2ccn(C)c(=O)c2)n1C,,O,,CCO,[Na+].[OH-],val
US20070249670A1,CCCCN(CC(=O)OCc1ccccc1)C(=O)c1cc2ccccc2cc1N.O=C=Nc1c(Cl)cccc1Cl>>CCCCN(CC(=O)OCc1ccccc1)C(=O)c1cc2ccccc2cc1NC(=O)Nc1c(Cl)cccc1Cl,,CN(C)C=O,,CCN(CC)CC,,val
US04007205,CCO.COc1ccc2oc3ccc(C(=O)O)cc3c(=O)c2c1>>CCOC(=O)c1ccc2oc3ccc(OC)cc3c(=O)c2c1,,O=S(=O)(O)O,,,,val
US20150239847A1,Fc1nccc(I)c1F.Nc1cc[nH]n1>>Nc1ccn(-c2nccc(I)c2F)n1,,O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20160075692A1,Fc1ccccc1-n1ncc2c(Br)cccc21.O=C1NCCN1[C@@H]1CCOC1>>O=C1N(c2cccc3c2cnn3-c2ccccc2F)CCN1[C@@H]1CCOC1,[Cu]I,C1COCCO1,CCOC(C)=O,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20150105556A1,COc1cccc(I)c1.c1ccc2[nH]ncc2c1>>COc1cccc(-n2ncc3ccccc32)c1,[Cu]I,Cc1ccccc1,,N[C@@H]1CCCC[C@H]1N,O=C([O-])[O-].[K+].[K+],val
US04877881,CCOC(=O)c1cc(C=Cc2ccc(O)c(OC)c2)n[nH]1>>COc1cc(C=Cc2cc(C(=O)O)[nH]n2)ccc1O,,CCO,O,Cl,[K+].[OH-],val
US20050187297A1,CCC(=O)Nc1ccc(O)cc1C(=O)OC.O=[N+]([O-])c1ccccc1F>>CCC(=O)Nc1ccc(Oc2ccccc2[N+](=O)[O-])cc1C(=O)OC,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20050085468A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc(O)c(N)cc1O>>CC(C)(C)OC(=O)c1c(N)c(O)cc(N)c1O,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US04625036,Fc1cc(C(F)(F)F)ccc1C1(CCl)CO1.c1nc[nH]n1>>Fc1cc(C(F)(F)F)ccc1C1(Cn2cncn2)CO1,,CC(C)(C)O,,[Na],,val
US20030130286A1,CCOC(=O)C(=O)OCC.CN1CCN(c2ccc(Nc3ncc(N)c(NC4CCCC4)n3)cc2)CC1>>CN1CCN(c2ccc(Nc3ncc4[nH]c(=O)c(=O)n(C5CCCC5)c4n3)cc2)CC1,,CCOCCO,,,,val
US20130172550A1,N#Cc1cccc(Nc2ccc3c(c2N)CCCC3)c1.O=C(Cl)CC(=O)Cl>>N#Cc1cccc(N2C(=O)CC(=O)Nc3c2ccc2c3CCCC2)c1,,C1CCOC1,,,,val
US20050197328A1,COc1ccc(-n2c(-c3nonc3N)nc3cnccc32)cc1>>Nc1nonc1-c1nc2cnccc2n1-c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,,val
US20100041891A1,CCOC(=O)c1cccc(-c2cccc3cc(Cc4ccc(OC)nc4)sc23)c1>>O=C(O)c1cccc(-c2cccc3cc(Cc4ccc(=O)[nH]c4)sc23)c1,,O,,CC(=O)O,Cl,val
US05629325,CC(C)(C)OC(=O)N1CC[C@H]1COc1cnc(Cl)c(CN)c1.O=C(Cl)c1ccccc1>>CC(C)(C)OC(=O)N1CC[C@H]1COc1cnc(Cl)c(CNC(=O)c2ccccc2)c1,,ClCCl,,CCN(CC)CC,,val
US04044151,C1N2CN3CN1CN(C2)C3.CN(C)S(=O)(=O)Nc1ccc(C(=O)CBr)cc1.Cl>>CN(C)S(=O)(=O)Nc1ccc(C(=O)CN)cc1.Cl,,CCO,,ClC(Cl)Cl,,val
US20030186983A1,CC(=O)OCc1ccn2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c12.CC(C)(CO)NC(=O)OC(C)(C)C>>CC(C)(N)COCc1ccn2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c12,,CC#N,,CCN(C(C)C)C(C)C,,val
US04654343,C=CCBr.CC(=O)Nc1cccc(-c2ccc3nnc(C)n3n2)c1>>C=CCN(C(C)=O)c1cccc(-c2ccc3nnc(C)n3n2)c1,,CN(C)C=O,,O,[H-].[Na+],val
US20100261698A1,CS(=O)(=O)Cl.Oc1cncc(Br)c1>>CS(=O)(=O)Oc1cncc(Br)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110190319A1,CCc1nn2ccccc2c1-c1cc(F)cc(F)c1.O=C1CCC(=O)N1Br>>CC(Br)c1nn2ccccc2c1-c1cc(F)cc(F)c1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20100292215A1,CC(C)(C)OC(=O)N1CCC(CO)CC1.COC(=O)c1ccc(O)cc1>>COC(=O)c1ccc(OCC2CCN(C(=O)OC(C)(C)C)CC2)cc1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US05104867,CNC(=O)[C@@H]1C[C@H](SCc2ccc(OC)cc2)CN1CCOS(C)(=O)=O>>COc1ccc(CS[C@H]2C[C@H]3C(=O)N(C)CCN3C2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20030199532A1,COc1ccc(-c2cnc(SCC(=O)NCC[C@@H]3C[C@@H](Cc4ccc(Cl)c(Cl)c4)CN3C(=O)OC(C)(C)C)nc2)cc1OC.Cl>>COc1ccc(-c2cnc(SCC(=O)NCC[C@@H]3C[C@@H](Cc4ccc(Cl)c(Cl)c4)CN3)nc2)cc1OC.Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110034445A1,NO.O=C(c1ccsc1)c1snc(Cl)c1Cl>>ON=C(c1ccsc1)c1snc(Cl)c1Cl,,c1ccncc1,,Cl,,val
US20040018986A1,CCOC(=O)c1[nH]c(C)c(C)c1C(C)=O>>CC(=O)c1c(C(=O)O)[nH]c(C)c1C,,CCO,,[K+].[OH-],,val
US20070161617A1,C[C@@H]1CN(Cc2cccc(N)c2F)CCN1C(=O)OCc1ccccc1.Cc1cc(N)ccn1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cc(NC(=O)Nc2cccc(CN3CCN(C(=O)OCc4ccccc4)[C@H](C)C3)c2F)ccn1,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20130131016A1,C=C(c1ccc(F)c(Cl)c1)C(F)(F)F.CC1(C)OB(O)c2ccc(/C(Cl)=N/O)cc21>>CC1(C)OB(O)c2ccc(C3=NOC(c4ccc(F)c(Cl)c4)(C(F)(F)F)C3)cc21,,CN(C)C=O,,CCOC(C)=O,,val
US05294671,C=C(C)c1cccc(C(C)(C)N=C=O)c1.Nc1nc(N)nc(N)n1>>C=C(C)c1cccc(C(C)(C)N=C=O)c1.Nc1nc(N)nc(N)n1,,CS(C)=O,,,,val
US20090137557A1,BrBr.COCc1cc(=O)n(CCc2ccccc2)c(-c2ccccc2OCc2ccccc2)n1>>COCc1nc(-c2ccccc2OCc2ccccc2)n(CCc2ccccc2)c(=O)c1Br,,CC(=O)O,,CCOC(C)=O,,val
US07495007B2,COC(=O)C(C)(C)COc1ccc(Br)cc1[C@H]1NC(=O)C[C@@H](c2cc(Cl)ccc2C)[C@]12C(=O)Nc1cc(Cl)ccc12>>Cc1ccc(Cl)cc1C1CC(=O)NC(c2cc(Br)ccc2OCC(C)(C)C(=O)O)C12C(=O)Nc1cc(Cl)ccc12,,C1CCOC1,,O,[Na+].[OH-],val
US20120053204A1,CCOC(=O)c1c(O)nc2cc(C(F)(F)F)ccc2c1C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)c1c(OS(=O)(=O)C(F)(F)F)nc2cc(C(F)(F)F)ccc2c1C,,ClCCl,,CCN(CC)CC,,val
US20110201593A1,N#C[C@H]1CCC[C@@H](Nc2c([N+](=O)[O-])cnc3c2ccn3S(=O)(=O)c2ccccc2)C1>>N#C[C@H]1CCC[C@@H](Nc2c(N)cnc3c2ccn3S(=O)(=O)c2ccccc2)C1,[Fe],CO,O,[Cl-].[NH4+],,val
US20120170118A1,CCCCCC(=O)c1ccc2c(c1)C(CCC(=O)OCC)(CCC(=O)OCC)c1cc(C(=O)CCCCC)ccc1-2>>CCCCCC(=O)c1ccc2c(c1)C(CCC(=O)O)(CCC(=O)O)c1cc(C(=O)CCCCC)ccc1-2,,O,,Cl,[Na+].[OH-],val
US20160002263A1,C=CCOc1ccccc1CO.ClP(Cl)(c1ccccc1)(c1ccccc1)c1ccccc1>>C=CCOc1ccccc1CCl,,ClCCl,,,,val
US20130303511A1,CC12CC3(C)CC(Cn4cccn4)(C1)CC(OCCO)(C2)C3.CI>>Cc1ccnn1CC12CC3(C)CC(C)(C1)CC(OCCO)(C3)C2,,C1CCOC1,,[Li]CCCC,,val
US20090227570A1,NO.O=C1CC2CCCC(C1)N2CC(F)(F)F>>ON=C1CC2CCCC(C1)N2CC(F)(F)F,,CCO,,Cl,,val
US20100311750A1,CCOC(=O)C1CCNCC1.COC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1c1nc(Cl)ncc1Cl>>COC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1c1nc(N2CCC(C(=O)O)CC2)ncc1Cl,,CC(C)O,,Cl,[Na+].[OH-],val
US04661601,CCCCCC(=O)NC(C)CCCC(C)(C)O.Oc1cccc(O)c1>>CCCCCC(=O)NC(C)CCCC(C)(C)c1ccc(O)cc1O,,O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080039460A1,Nc1cnc2[nH]c(-c3ccccc3)nc2c1.O=C(Cl)c1ccccc1Cl>>O=C(Nc1cnc2[nH]c(-c3ccccc3)nc2c1)c1ccccc1Cl,,c1ccncc1,,,,val
US20110039892A1,C[C@@H](N)c1cc(F)cc(F)c1.N#CC(C(N)=O)C1OC(=O)C(Cl)=C1Cl>>C[C@H](c1cc(F)cc(F)c1)n1cc(Cl)cc(C(N)=O)c1=N.Cl,,CO,,CCN(CC)CC,,val
US04596666,Nc1c(C2=NCCCO2)cc([N+](=O)[O-])c2c1C(=O)c1ccccc1C2=O.Sc1ccc(Cl)cc1>>Nc1c(C2=NCCCO2)cc(Sc2ccc(Cl)cc2)c2c1C(=O)c1ccccc1C2=O,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20030153596A1,Cc1ncsc1CCOS(C)(=O)=O.O=C1NC(=O)c2ccccc21>>Cc1ncsc1CCN1C(=O)c2ccccc2C1=O,,CN(C)C=O,,[K],,val
US20100316601A1,COc1c(-c2cc(C(=O)O)c(C)o2)cccc1[N+](=O)[O-]>>COc1c(N)cccc1-c1cc(C(=O)O)c(C)o1,[Pd],CO,,,,val
US20040214832A1,CC(=O)c1ccc2c(c1)NC(=O)CO2.O=C(OO)c1cccc(Cl)c1>>CC(=O)Oc1ccc2c(c1)NC(=O)CO2,,ClCCl,,O=C([O-])O.[Na+],,val
US20100190831A1,CCOC(=O)C=C1CCCc2cc(OC)ccc21>>CCOC(=O)CC1CCCc2cc(OC)ccc21,[Pd],CCO,,[H][H],,val
US20130261106A1,CC(C)Oc1cc(C2CCN(C)CC2)ccc1N.O=CO>>CC(C)Oc1cc(C2CCN(C)CC2)ccc1NC=O,,O=CO,,CC(=O)OC(C)=O,,val
US20120329649A1,O=C1NC(=O)c2ccccc21.O=Cc1ccc(CBr)c2ccccc12>>O=Cc1ccc(CN2C(=O)c3ccccc3C2=O)c2ccccc12,,CN(C)C=O,O,[K],,val
US20070179143A1,COC(=O)c1cc(F)cc(CC#N)c1>>N#CCc1cc(F)cc(CO)c1,,C1CCOC1,,,,val
US04374138,CCN=C=O.Nc1ccc2[nH]c(=O)c(C(=O)O)cc2c1>>CCNC(=O)Nc1ccc2[nH]c(=O)c(C(=O)O)cc2c1,,CN(C)C=O,,CCN(CC)CC,,val
US20060035920A1,CCn1c(=O)c2c(C)n(C3CCCCO3)nc2c2cc(C#CCO)ccc21>>CCn1c(=O)c2c(C)n(C3CCCCO3)nc2c2cc(C#CC=O)ccc21,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090022670A1,CC(C)(C)OC(=O)N1CCCC[C@H]1CC(=O)CBr.CC(C)(C)[Si](C)(C)OCc1cc(F)cnc1N>>OCc1cc(F)cn2cc(C[C@@H]3CCCCN3)nc12,,CN(C)C=O,,,,val
US05434181,CCNCC1CCOC1.CN=C(N[N+](=O)[O-])SC>>CCN(CC1CCOC1)C(=N[N+](=O)[O-])NC,CN(C)c1ccncc1,CCO,,,,val
US20100249149A1,CCBr.CCOc1ccccc1-c1cc(NC(=O)C2CCNCC2)ncn1>>CCOc1ccccc1-c1cc(NC(=O)C2CCN(CC)CC2)ncn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
USRE036562,CC(=O)Cl.CCNC(=O)c1cccc([Si](C)(C)C)c1Cl>>CCN(C(C)=O)C(=O)c1c(Cl)cccc1[Si](C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20030203915A1,O=NSC1(CC(=O)O)C2CC3CC(C2)CC1C3.O=[N+]([O-])OCC(CO)(CO[N+](=O)[O-])CO[N+](=O)[O-]>>O=NSC1(CC(=O)OCC(CO[N+](=O)[O-])(CO[N+](=O)[O-])CO[N+](=O)[O-])C2CC3CC(C2)CC1C3,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US05376684,CC(=O)O.CCO[PH](=O)CC1CCCCC1.ClCCl>>CCOP(=O)(CC1CCCCC1)C[C@@H](O)CCl,,C1CCOC1,,CCN(CC)CC,C[Si](C)(C)Cl,val
US20090018103A1,CC(C)(C)OC(=O)N1CCC[C@H](NC(=O)Oc2ccc([N+](=O)[O-])cc2)C1.COCCCC[C@@](O)(c1cccc(F)c1-c1cccc(C)c1)[C@@H]1CCCNC1>>COCCCC[C@@](O)(c1cccc(F)c1-c1cccc(C)c1)[C@@H]1CCCN(C(=O)N[C@H]2CCCN(C(=O)OC(C)(C)C)C2)C1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US05700809,CC(=O)N1CCC(O)(c2ccc3ccccc3c2)CC1>>C1=C(c2ccc3ccccc3c2)CCNC1,,Cl,,[Na+].[OH-],,val
US20130150339A1,COc1cc(Cl)ccc1-c1nccc2cc(S(=O)(=O)Nc3ccncn3)ccc12.Cc1ccccc1B(O)O>>COc1cc(-c2ccccc2C)ccc1-c1nccc2cc(S(=O)(=O)Nc3ccncn3)ccc12,,O,,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20150119411A1,Cc1ccc(Cn2c(=O)n(Cc3ccc(C(=O)O)cc3)c(=O)c3ccccc32)cc1.NCC1COC1>>Cc1ccc(Cn2c(=O)n(Cc3ccc(C(=O)NCC4COC4)cc3)c(=O)c3ccccc32)cc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20100016306A1,C[C@H]1CNC[C@@H](C)N1.Clc1nc(N2CCOCC2)c2sc(CBr)cc2n1>>C[C@H]1CN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)C[C@@H](C)N1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05804589,CC1CCN(C(=O)[C@H]2CC=CC[C@@H]2NC(=O)C(F)(F)F)CC1>>C=C1CCN(C(=O)[C@@H]2CCCC[C@@H]2N)CC1,[Pd],CO,,Cl,,val
US20050075376A1,COC(=O)/C=C/c1cc(-c2ccc(OCc3ccccc3)cc2)n(C2CCCCC2)n1>>COC(=O)CCc1cc(-c2ccc(OCc3ccccc3)cc2)n(C2CCCCC2)n1,[Pd],c1ccccc1,,,,val
US20080234262A1,C[C@H]1CNC[C@@H](C)O1.Oc1cccc(-c2nc(Br)c3cnn(-c4ccccc4)c3n2)c1>>C[C@H]1CN(c2nc(-c3cccc(O)c3)nc3c2cnn3-c2ccccc2)C[C@@H](C)O1,,CCO,,,,val
US04362728,CN.CSC(=NC#N)NCCCCCc1csc(NC(N)=NCC(F)(F)F)n1>>CN=C(NC#N)NCCCCCc1csc(NC(N)=NCC(F)(F)F)n1,,CCO,,,,val
US04293694,O=C(O)c1cn2c3c(cccc3c1=O)C1CCCCC12.O=[N+]([O-])O>>O=C(O)c1cn2c3c(ccc([N+](=O)[O-])c3c1=O)C1CCCCC12,,O=S(=O)(O)O,,,,val
US20020009650A1,Nc1nccnn1.O=S=O>>O=S(=O)=c1nccn[nH]1,Cl[Cu]Cl,CC(=O)O,O,CCOCC,Cl,val
US03946025,BrBr.Nc1ccc(C(F)(F)F)cc1>>Nc1ccc(C(F)(F)F)cc1Br,[Fe],,,Br,,val
US20090264462A1,CC(C)[C@H](N)CN1CC[C@@](C)(c2cccc(O)c2)[C@@H](C)C1.COc1ccc2c(c1)CN(C(=O)OC(C)(C)C)[C@@](C)(C(=O)O)C2>>COc1ccc2c(c1)CN(C(=O)OC(C)(C)C)[C@@](C)(C(=O)N[C@H](CN1CC[C@@](C)(c3cccc(O)c3)[C@@H](C)C1)C(C)C)C2,,C1CCOC1,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20130059853A1,CC(C)CBr.COc1c(OC(F)F)ccc(-c2cccc3c2CCC3=O)c1O>>COc1c(OC(F)F)ccc(-c2cccc3c2CCC3=O)c1OCC(C)C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160083362A1,COC(=O)c1c(N(C(=O)OC)S(=O)(=O)c2ccc(F)cc2/C=C\COS(C)(=O)=O)ccc2c1OC[C@@H]1C[C@H]21.OC[C@H]1CCNC1>>COC(=O)c1c(N(C(=O)OC)S(=O)(=O)c2ccc(F)cc2/C=C\CN2CC[C@H](CO)C2)ccc2c1OC[C@@H]1C[C@H]21,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20080249334A1,CCC(=O)O.N.O=[N+]([O-])c1ccc(O)cc1>>NC(=O)CCc1ccc(O)cc1,,CCOC(C)=O,,,,val
US06528497B1,CI.COc1ccc(O[C@@H]2[C@H]3CO[C@H](O3)[C@H](OS(=O)(=O)c3ccc(C)cc3)[C@H]2O)cc1>>COc1ccc(O[C@@H]2[C@H]3CO[C@H](O3)[C@H](OS(=O)(=O)c3ccc(C)cc3)[C@H]2OC)cc1,O=[Ag],CN(C)C=O,,,,val
US03998954,CC(C)N.O=C(O)Cc1ccccc1C(=O)O>>CC(C)N1C(=O)Cc2ccccc2C1=O,,CCO,,C,,val
US20080027048A1,COC(=O)c1ccc(-c2ccc(O)c(C#N)c2)s1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1ccc(-c2ccc(OS(=O)(=O)C(F)(F)F)c(C#N)c2)s1,,c1ccncc1,,,,val
US20140100231A1,COc1nnc(COC2CCCCO2)cc1Cn1cnc(C(F)(F)F)c(Oc2cc(Cl)cc(C#N)c2)c1=O>>COc1nnc(CO)cc1Cn1cnc(C(F)(F)F)c(Oc2cc(Cl)cc(C#N)c2)c1=O,,CO,,Cl,,val
US20130059883A1,[N-]=[N+]=NCc1coc(-c2ccc(F)cc2)n1>>NCc1coc(-c2ccc(F)cc2)n1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04074051,CN(C)CC1CN(c2ccccc2)NC1=O.O=C(O)C(=O)O>>CN(C)CC1CN(c2ccccc2)NC1=O.O=C(O)C(=O)O,,CC(C)=O,,,,val
US04885367,O=[N+]([O-])c1ccccc1OC1CCCCC1>>Nc1ccccc1OC1CCCCC1,[Pd],CO,,,,val
US20020006922A1,CC(C)=O.COc1ccc(S)cc1.O=C(NO)C1(S(=O)(=O)c2ccc(OCc3ccccc3)cc2)CCN(Cc2ccccc2)CC1>>CCOC(=O)CSc1ccc(OC)cc1,,CC(C)=O,,,,val
US20100093759A1,CN(C)CN(C)C.Cc1cc(C)c2cc[nH]c2c1>>Cc1cc(C)c2c(CN(C)C)c[nH]c2c1,,CC(=O)O,,,,val
US05693841,CCC[Si]1(c2ccccc2)CCC(C2CCC(=O)CC2)CC1.Fc1ccc([Mg]Cl)cc1>>CCC[Si]1(c2ccccc2)CCC(C2CC=C(c3ccc(F)cc3)CC2)CC1,,C1CCOC1,,[Cl-].[NH4+],,val
US05401769,CCCCN=C=O.Oc1ccc2oc3ccccc3c2c1>>CCCCNC(=O)Oc1ccc2oc3ccccc3c2c1,,ClCCl,,CCN(CC)CC,,val
US20130267510A1,COCOc1ccc(C)c2c1C1(CC1)CO2>>Cc1ccc(O)c2c1OCC21CC1,,CCO,Cl,O,,val
US20100305096A1,CC1(O)CCN(C2CN(C(=O)OC(C)(C)C)C2)CC1>>CC1(O)CCN(C2CNC2)CC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20160046653A1,CC[SiH](CC)CC.Cn1ccc2cc(OCc3ccccc3)ccc21>>CC[Si](CC)(CC)c1cc2cc(OCc3ccccc3)ccc2n1C,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US04957927,BrC(c1ccccc1)c1ccccc1.OCCBr>>BrCCOC(c1ccccc1)c1ccccc1,,CCOCC,,O=C([O-])[O-].[Na+].[Na+],,val
US06034239,C=CCBr.CCC(=O)NCC[C@@H]1CCc2cc(Br)c(O)cc21>>C=CCOc1cc2c(cc1Br)CC[C@H]2CCNC(=O)CC,,CN(C)C=O,,Cl,[H-].[Na+],val
US20060128734A1,O=C(Nc1ccc(CN2CCCCC2)c(C(F)(F)F)c1)C(F)(F)F>>Nc1ccc(CN2CCCCC2)c(C(F)(F)F)c1,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US06613942B1,COC(=O)c1ccc(O)c(C#N)c1>>N#Cc1cc(C(=O)O)ccc1O,,C1CCOC1,,[K+].[OH-],,val
US20070003539A1,CCCC(=O)Nc1cccc(C#N)c1>>CCCC(=O)Nc1cccc(CN)c1,[Pd],CO,Cl,[H][H],,val
US20120225867A1,CCOC(=O)/C(O)=C1\COCCC1=O.NN>>CCOC(=O)c1[nH]nc2c1COCC2,,CO,,Cl,,val
US20080312316A1,CC(C)C(=O)C(C(=O)c1ccc(F)c(F)c1O)c1ccc(Cl)cc1>>CC(C)c1oc2c(F)c(F)ccc2c(=O)c1-c1ccc(Cl)cc1,,CC(=O)O,Cl,,,val
US06271227B1,CN(C)C=S.O=Cc1ccc(OCc2ccccc2)cc1>>CN(C)C(=S)C(O)c1ccc(OCc2ccccc2)cc1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20020115721A1,C[C@H](C[C@H](N)C(=O)O)C(=O)O.O=C(Cl)OCc1ccccc1>>C[C@H](C[C@H](NC(=O)OCc1ccccc1)C(=O)O)C(=O)O,,[Na+],[OH-],Cl,O=C(O)C(F)(F)F,val
US20090082464A1,C=CCC(C)(C)CO.CC(C)(C)[Si](C)(C)Cl>>C=CCC(C)(C)CO[Si](C)(C)C(C)(C)C,,ClCCl,,c1c[nH]cn1,,val
US20160096839A1,C=CC[C@H](NC(=O)OC(C)(C)C)c1cc(-c2c([N+](=O)[O-])cnn2CCO[Si](C)(C)C(C)(C)C)ccn1>>C=CC[C@H](NC(=O)OC(C)(C)C)c1cc(-c2c(N)cnn2CCO[Si](C)(C)C(C)(C)C)ccn1,[Zn],CC(=O)O,CO,O,O=C([O-])[O-].[K+].[K+],val
US20020019388A1,N#CCc1cc(N2C[C@H]3CCN[C@H]3C2)cnc1Br.O=C(O)/C=C/C(=O)O>>N#CCc1cc(N2C[C@H]3CCN[C@H]3C2)cnc1Br.O=C(O)/C=C/C(=O)O,,CCOCC,CO,,,val
US20090029976A1,CC(C)N1CCC(O)CC1.CCOC(=O)c1cc2ccc(O)cc2s1>>CCOC(=O)c1cc2ccc(OC3CCN(C(C)C)CC3)cc2s1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04581452,C=C(C(=O)O)C(F)(F)F.NC(=O)Nc1ccccc1>>O=C(NCC(C(=O)O)C(F)(F)F)Nc1ccccc1,,CN(C)C=O,,,,val
US20090105217A1,FC1CCNCC1.O=C1c2ccccc2C(=O)N1CCCCBr>>NCCCCN1CCC(F)CC1,,CCO,,CCN(CC)CC,Cl,val
US20050059687A1,COc1ccc(S(=O)(=O)N2CCN(Cc3nc4ccccc4c(=O)[nH]3)CC2)cc1.IC1CCCC1>>COc1ccc(S(=O)(=O)N2CCN(Cc3nc(OC4CCCC4)c4ccccc4n3)CC2)cc1,,CN(C)C=O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20100120751A1,CC(C)(C)OC(=O)N1CC(=S)Nc2ccc(Cl)cc2C1.NNC=O>>CC(C)(C)OC(=O)N1Cc2cc(Cl)ccc2-n2cnnc2C1,,C1COCCO1,,,,val
US07071201B2,CN(C)C=O.Fc1ccccc1CCN1CCC(N2CCc3ccc(Br)cc32)CC1>>O=Cc1ccc2c(c1)N(C1CCN(CCc3ccccc3F)CC1)CC2,,C1CCOC1,CCCCCC,CCOC(C)=O,[Cl-].[NH4+],val
US05888940,CSSC.Nc1nc2c(Cl)cc(Cl)cc2s1>>CSc1nc2c(Cl)cc(Cl)cc2s1,,ClCCCl,,CC(C)(C)ON=O,,val
US05135976,C=CCOCCCC(=O)CCC(C)=O.O=C(OO)c1cccc(Cl)c1>>CC(=O)CCC(=O)CCCOCC1CO1,,ClC(Cl)Cl,,,,val
US20070135433A1,CC(C)(CN)c1nc(-c2ccc3c(c2)CCC3=O)c(-c2ccncc2)[nH]1.NO>>CC(C)(CN)c1nc(-c2ccc3c(c2)CCC3=NO)c(-c2ccncc2)[nH]1,,CCO,,,,val
US20020087002A1,COc1cc(CO[C@H]2CN(C(=O)OC(C)(C)C)C[C@@H](OC[C@H]3COC(C)(C)O3)[C@@H]2c2ccc(OCCCOc3ccccc3C#N)cc2)cc2ccccc12>>COc1cc(CO[C@H]2CNC[C@@H](OC[C@H](O)CO)[C@@H]2c2ccc(OCCCOc3ccccc3C#N)cc2)cc2ccccc12,,CO,,Cl,,val
US20140187542A1,COc1ccc2ncc(=O)n(CCCC=O)c2c1.NC1CC(=O)N(c2ccc3c(c2)NC(=O)CO3)C1>>COc1ccc2ncc(=O)n(CCCCNC3CC(=O)N(c4ccc5c(c4)NC(=O)CO5)C3)c2c1,,CO,ClC(Cl)Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040242606A1,CC(C)(C)C(=O)OCc1nc2cc3c(cc2c(=O)[nH]1)CCC3.CC(C)(C)OO>>CC(C)(C)C(=O)OCc1nc2cc3c(cc2c(=O)[nH]1)C(=O)CC3,,ClCCl,,,,val
US20160002255A1,CC#CC(CC(=O)OC)c1ccc2c(c1)CCC(c1cccc(Br)c1)O2.Cc1cccc(C)c1B(O)O>>CC#CC(CC(=O)OC)c1ccc2c(c1)CCC(c1cccc(-c3c(C)cccc3C)c1)O2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20100311800A1,CC(CCCCOC(=O)c1ccc([N+](=O)[O-])cc1)O[N+](=O)[O-]>>CC(CCCCO)O[N+](=O)[O-],,CO,,[Na+].[OH-],,val
US04822682,C1=C(c2ccccc2)O1.O=C(O)c1ccc(-c2ccc(OCCCCCCO)cc2)cc1>>O=C(OCC(O)c1ccccc1)c1ccc(-c2ccc(OCCCCCCO)cc2)cc1,,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20150210682A1,COc1cc(CC(C)NC=O)cc(OC)c1>>COc1cc2c(c(OC)c1)C=NC(C)C2,,CC#N,,O=P(Cl)(Cl)Cl,,val
US07045360B2,CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)F.NCCS>>CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)NCCS,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US20120302573A1,COc1ccc(F)cc1NC(N)=S.Cc1nc(C)n(C)c1C(=O)CBr>>COc1ccc(F)cc1Nc1nc(-c2c(C)nc(C)n2C)cs1,,CCO,,,,val
US20110028450A1,CCCC[Sn](CCCC)(CCCC)c1cnccn1.COc1cc2c(cc1Br)-c1c(-c3cccs3)c3c(n1CC2)C(=O)N(C(C)(C)C)CCCOC3>>COc1cc2c(cc1-c1cnccn1)-c1c(-c3cccs3)c3c(n1CC2)C(=O)N(C(C)(C)C)CCCOC3,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCOCC,,val
US20130131051A1,O=C(O)CC/C=C/c1ccc(Br)c(F)c1>>O=C(O)CCCCc1ccc(Br)c(F)c1,,CC(C)O,,,,val
US20080269220A1,Cc1cc(O)cc(C)c1-c1cccc(CN(c2ccc(CCC(=O)OC(C)(C)C)c(F)c2)S(=O)(=O)c2ccccc2[N+](=O)[O-])c1.OC1CCSCC1>>Cc1cc(OC2CCSCC2)cc(C)c1-c1cccc(CN(c2ccc(CCC(=O)OC(C)(C)C)c(F)c2)S(=O)(=O)c2ccccc2[N+](=O)[O-])c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06403776B1,C[C@H](CCN(NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n1cnc(-c2cccnc2)c1>>C[C@H](CCNN)n1cnc(-c2cccnc2)c1,,CO,,Cl,,val
US20070049618A1,COc1cccc(N=C=O)c1.NCc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O>>COc1cccc(NC(=O)NCc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)c1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20080085898A1,Cc1nc2cnc(-n3cnc4ccc(C#N)cc43)nc2n1[C@@H]1CC[C@@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c2ccccc21>>Cc1nc2cnc(-n3cnc4ccc(C#N)cc43)nc2n1[C@@H]1CC[C@@H](O)c2ccccc21,,CN(C)C=O,,[Cs+].[F-],,val
US04446323,COc1cccc(OC)c1C(=O)Cl.c1ccc2c(c1)NCC1CCCN21>>COc1cccc(OC)c1C(=O)N1CC2CCCN2c2ccccc21,,CC(C)=O,,CCN(CC)CC,,val
US08138168B1,CC(C)(C)OC(=O)N1CCC[C@@H](c2nc3ccccc3[nH]2)C1.COCCCBr>>COCCCn1c([C@@H]2CCCN(C(=O)OC(C)(C)C)C2)nc2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20100120763A1,COc1cc(C(F)(F)F)cc2c1nnc1c(C)nc(Br)n12.OB(O)c1ccccc1Cl>>COc1cc(C(F)(F)F)cc2c1nnc1c(C)nc(-c3ccccc3Cl)n12,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20100190814A1,CCC(CC)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)Nc1cc(Cl)ccc12)C(=O)NS(C)(=O)=O.CCOC(=O)Cl>>CCOC(=O)N1C(=O)C2(c3ccc(Cl)cc31)C(c1cc(Cl)ccc1OC(CC)(CC)C(=O)NS(C)(=O)=O)CC(=O)NC2c1cc(F)ccc1C,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,,,val
US20040121965A1,CN.Cc1cccc(C(C)(C)C(=O)C(=O)O)c1>>CN[C@H](C(=O)O)C(C)(C)c1cccc(C)c1,,C1CCOC1,,,,val
US06153768,COCOc1ccc(C2(C)CSc3cc(OCOC)ccc3C2c2ccc(OCCCCCS(=O)(=O)CCCC(F)(F)C(F)(F)F)cc2)cc1>>CC1(c2ccc(O)cc2)CSc2cc(O)ccc2C1c1ccc(OCCCCCS(=O)(=O)CCCC(F)(F)C(F)(F)F)cc1,,O,,C1CCOC1,Cl,val
US20050107449A1,Cc1cc(O)ccc1CCC(=O)OC(C)(C)C.Cc1sc(-c2ccc(-c3ccccc3F)nc2)nc1CCO>>Cc1cc(OCCc2nc(-c3ccc(-c4ccccc4F)nc3)sc2C)ccc1CCC(=O)OC(C)(C)C,,Cc1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20080255083A1,C1CCNC1.O=c1cc(OCc2ccsc2)ccn1CCc1ccc(CBr)cc1>>O=c1cc(OCc2ccsc2)ccn1CCc1ccc(CN2CCCC2)cc1,,CC#N,,,,val
US20060160817A1,CCOC(=O)CC(=O)c1ccccc1F.COC(OC)N(C)C>>CCOC(=O)C(=CN(C)C)C(=O)c1ccccc1F,,Cc1ccccc1,,,,val
US20120129840A1,CC(C)c1noc(C2CCCNC2)n1.CCCC(C(=O)OC)c1c(C)nc(Cl)nc1-c1ccc(C)cc1>>CCCC(C(=O)OC)c1c(C)nc(N2CCCC(c3nc(C(C)C)no3)C2)nc1-c1ccc(C)cc1,,C1CCOC1,,CCN(CC)CC,,val
US04212868,NNc1ccccc1.O=Cc1cccnc1>>C(=NNc1ccccc1)c1cccnc1,,CCO,,,,val
US04923868,CCOC(=O)c1c(=O)c2cc(F)c(F)cc2n2ccccc12>>CCOC(=O)c1c2n(c3cc(F)c(F)cc3c1=O)CCCC2,[Pd],O=C(O)C(F)(F)F,,[H][H],,val
US20120232052A1,CC(=O)c1cccc(O)c1.CC(C)(C)OC(=O)N1CCC(O)CC1>>CC(=O)c1cccc(OC2CCN(C(=O)OC(C)(C)C)CC2)c1,,C1CCOC1,O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06627651B1,CCOC(=O)c1cc2ccc(-c3ccc(C)cc3)cc2[nH]1.CI>>CCOC(=O)c1cc2ccc(-c3ccc(C)cc3)cc2n1C,,CN(C)C=O,,O,[H-].[Na+],val
US20070060577A1,CN1CCN(c2ccc(Nc3ncc4c(=O)c(C#N)cn(-c5ccccc5)c4n3)cc2)CC1.[OH-]>>CN1CCN(c2ccc(Nc3ncc4c(=O)c(C(N)=O)cn(-c5ccccc5)c4n3)cc2)CC1,,CC(C)(C)O,,O,,val
US04116956,COc1ccc(C2=NCC(N)=Nc3ccc(Cl)cc32)cc1.NN>>COc1ccc(C2=NCC(NN)=Nc3ccc(Cl)cc32)cc1,,CC(=O)O,,CO,O,val
US20090054465A1,CC(C)(C)OC(=O)N1CC[C@@H](N)C1.COC(=O)/C=C/c1cnc(Cl)cn1>>COC(=O)/C=C/c1cnc(N[C@@H]2CCN(C(=O)OC(C)(C)C)C2)cn1,,CC(=O)N(C)C,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20140171422A1,COS(=O)(=O)c1ccc(C)cc1.O=c1[nH]ccc2scc(Br)c12>>Cn1ccc2scc(Br)c2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20060217426A1,CC(=O)OC(C)=O.COC(=O)c1c(NC(=O)c2ccc(OC)c(OC)c2)sc(O)c1C>>COC(=O)c1cc(COC(C)=O)sc1NC(=O)c1ccc(OC)c(OC)c1,,ClCCl,,c1ccncc1,,val
US20050085520A1,COC(=O)c1cc(N2CCCC2=O)cc(N2CCCC2=O)c1>>O=C(O)c1cc(N2CCCC2=O)cc(N2CCCC2=O)c1,,C1COCCO1,,O,[Li+].[OH-],val
US20090214675A1,CCOC(=O)C(=Cc1cc(F)cc2c(=O)cc(C)oc12)C(C)=O.N#CC=C(N)C(F)(F)F>>CCOC(=O)C1=C(C)NC(C(F)(F)F)=C(C#N)C1c1cc(F)cc2c(=O)cc(C)oc12,,CC(C)O,,CC(C)(C)[O-].[K+],,val
US06057324,CCOC(=O)CN1CCC(N2CCN(c3ccc(C#N)cc3)C(=O)C2)CC1.NO>>CCOC(=O)CN1CCC(N2CCN(c3ccc(C(=N)NO)cc3)C(=O)C2)CC1,,CCN(CC)CC,,CCO,Cl,val
US20090137595A1,Cc1nc2ccc(O)cc2s1.O=C(Nc1cn2nc(I)ccc2n1)C1CC1>>Cc1nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)cc2s1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120196848A1,C=C(C)B1OC(C)(C)C(C)(C)O1.CC1CN(C(=O)OC(C)(C)C)Cc2scc(Br)c2O1>>C=C(C)c1csc2c1OC(C)CN(C(=O)OC(C)(C)C)C2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20120101123A1,CCOC(=O)CCCn1ccc2c(-c3noc(-c4cnc(OC(C)C)c(Cl)c4)n3)ccnc21>>CC(C)Oc1ncc(-c2nc(-c3ccnc4c3ccn4CCCC(=O)O)no2)cc1Cl,,CC(C)O,O,[Na+].[OH-],,val
US20130172331A1,COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.C[C@]1(c2nc(Br)ccc2F)N=C(N)OCC1(F)F>>COc1ccc(C(NC2=N[C@](C)(c3nc(Br)ccc3F)C(F)(F)CO2)(c2ccccc2)c2ccc(OC)cc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20040138277A1,CCOC(=O)C(C)(Cc1cccc2ccccc12)Oc1ccccc1.Cc1ccc(S(=O)(=O)OCCc2nc(-c3cccc(-c4ccccc4)c3)oc2C)cc1>>Cc1oc(-c2cccc(-c3ccccc3)c2)nc1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)c2ccccc12,,CCO,,,,val
US20030149104A1,CCOC(=O)C(Cc1ccc(O)c(Cc2ccccc2)c1)OCC.Cc1ccc(S(=O)(=O)OCCc2ccc(NC(=O)OC(C)(C)C)cc2)cc1>>CCOC(=O)C(Cc1ccc(OCCc2ccc(NC(=O)OC(C)(C)C)cc2)c(Cc2ccccc2)c1)OCC,,CCC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20140128614A1,CCC(=O)NCc1ccc(N2CC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)OC2=O)cc1C(F)(F)F>>CCC(=O)NCc1ccc(NCC(O)(c2cc(Cl)c(Cl)c(Cl)c2)C(F)(F)F)cc1C(F)(F)F,,C1COCCO1,,O,[K+].[OH-],val
US04068026,NC(N)=O.O=S(=O)([O-])[O-].OC[P+](CO)(CO)CO.OC[P+](CO)(CO)CO>>NC(N)=O.O=S(=O)([O-])[O-].OC[P+](CO)(CO)CO.OC[P+](CO)(CO)CO,,O,,CC(=O)[O-].[Na+],,val
US20020013451A1,CCCCCC.CCCCCCCCBr.[Li]CCCC.c1ccc2c(c1)Cc1ccccc1-2>>CCCCCCCCC1(CCCCCCCC)c2ccccc2-c2ccccc21,,C1CCOC1,CCCCCC,O,,val
US20110178001A1,O=C1CCCC(=O)O1.OCC1c2ccccc2-c2ccccc21>>O=C(O)CCCC(=O)OCC1c2ccccc2-c2ccccc21,CN(C)c1ccncc1,ClCCl,,,,val
US05559230,CCOC(=O)CBr.CNC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21>>CCOC(=O)CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05399575,N#CCCCCBr.Oc1ccc(C=Cc2ccncc2)cc1>>N#CCCCCOc1ccc(C=Cc2ccncc2)cc1,,CC(C)O,,[Na],,val
US20080051399A1,CC(=O)OC1CCc2c(Cl)ncnc21.CC(C)(C)OC(=O)N1CCNCC1>>CC(=O)OC1CCc2c1ncnc2N1CCN(C(=O)OC(C)(C)C)CC1,,CCOC(C)=O,CN1CCCC1=O,,,val
US20150210720A1,CC(=O)N1CCN(c2ccc([N+](=O)[O-])c(OC3CS(=O)C3)n2)CC1>>CC(=O)N1CCN(c2ccc(N)c(OC3CS(=O)C3)n2)CC1,[Pd],C1CCOC1,,,,val
US20030036651A1,COC(=O)CCCC=Cc1ccccn1>>COC(=O)CCCCCc1ccccn1,[Pd],CO,,,,val
US20070281918A1,CC1CN(C(=O)C(F)(F)F)CCc2nc(Cl)c(I)cc21>>CC1CNCCc2nc(Cl)c(I)cc21,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20070197513A1,COc1ccccc1-c1nc(CO)cn1-c1ccc(C)cc1.Cn1c(CCl)nc2ccccc21>>COc1ccccc1-c1nc(COC(c2ccc(C)cc2)c2nc3ccccc3n2C)c[nH]1,,C1CCOC1,,CCOC(C)=O,[H-].[Na+],val
US20150197509A1,N#Cc1cc(F)cc(-c2ccc(C(F)(F)F)cc2)c1>>NCc1cc(F)cc(-c2ccc(C(F)(F)F)cc2)c1,[Pd],CCO,,[H][H],,val
US20080269275A1,CN1CCC(Oc2cccc(CN)c2)CC1.O=Cc1cccc(Oc2ccccc2)c1>>CN1CCC(Oc2cccc(CNCc3ccc(Oc4ccccc4)cc3)c2)CC1,CC(=O)O,CO,,[BH3-]C#N.[Na+],,val
US05962495,N#Cc1ccc(C(C(O)CCc2ccccc2)n2cncn2)cc1>>N#Cc1ccc(C(=CCCc2ccccc2)n2cncn2)cc1,,CC#N,,ClP(Cl)(Cl)(Cl)Cl,,val
US20110059941A1,COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2nc3cc(C(N)=O)cnc3[nH]2)c1>>COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2nc3cc(C#N)cnc3[nH]2)c1,,C1COCCO1,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US20160009744A1,OCc1ccc(Cc2cccc(Br)c2)o1>>O=Cc1ccc(Cc2cccc(Br)c2)o1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20050004162A1,CCOC(=O)Cc1coc2ccc(F)cc12>>OCCc1coc2ccc(F)cc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120295923A1,COC(=O)C[C@@H]1CC[C@@H](N(CC2CCCC2)CC2CCCC2)[C@H](c2ccc(C(F)(F)F)cc2)C1>>O=C(O)C[C@@H]1CC[C@@H](N(CC2CCCC2)CC2CCCC2)[C@H](c2ccc(C(F)(F)F)cc2)C1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20120122900A1,CS(=O)(=O)OCc1cc(Br)cnc1COS(C)(=O)=O.C[Si](C)(C)CCOCN1C(=O)Cc2cccnc21>>C[Si](C)(C)CCOCN1C(=O)C2(Cc3cc(Br)cnc3C2)c2cccnc21,,CCO,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140031364A1,COC(=O)c1c(-c2ccccc2OC(F)(F)F)noc1N>>Nc1onc(-c2ccccc2OC(F)(F)F)c1C(=O)O,,CO,,[Na+].[OH-],,val
US05198588,C=C[C@@H](C=C[C@H](CCCCC)OCc1ccccc1)[C@@H](CC(OC)OC)OCc1ccccc1.O=C([O-])O>>C=C[C@@H](C=C[C@H](CCCCC)OCc1ccccc1)[C@@H](CCC=O)OCc1ccccc1,,C1CCOC1,,CC(=O)O,,val
US20130085132A1,C=C(C(=O)OC)C1(C(=O)OC)CC1.COc1ccc(CN)c(OC)c1>>COC(=O)C1CN(Cc2ccc(OC)cc2OC)C(=O)C12CC2,,Cc1ccccc1,,,,val
US20110166169A1,CO.COC(=O)c1cccc2c1c1ccccc1n2-c1ccc(C#N)cn1>>NC(=O)c1ccc(-n2c3ccccc3c3c(C(=O)O)cccc32)nc1,,CO,,[Na+].[OH-],,val
US20120065202A1,CCBr.CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCNC3)cc1>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(CC)C3)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20080306055A1,FC(F)(F)c1ccc(Cl)nc1.O=Cc1cc[nH]c1>>O=Cc1ccn(-c2ccc(C(F)(F)F)cn2)c1,,C1CCOC1,,[H-].[Na+],,val
US04436726,CCCCCC(=O)OC(=O)CCCCC.CCCCCC(O)CC(=O)OC(C)(C)C>>CCCCCC(=O)OC(CCCCC)CC(=O)OC(C)(C)C,,c1ccncc1,,Cl,O,val
US05698575,S=c1c(Br)coc2ccccc12.c1nc[nH]n1>>S=c1cc(-c2nc[nH]n2)oc2ccccc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140066443A1,O=Cc1ccc(-c2ccc3c(nnn3CC3CC3)c2C(F)(F)F)c(F)n1>>OCc1ccc(-c2ccc3c(nnn3CC3CC3)c2C(F)(F)F)c(F)n1,,CCOC(C)=O,ClCCl,[BH4-].[Na+],,val
US20040058978A1,CC(=O)N1C(=O)C(=C(O)c2ccccc2)c2ccccc21.ClP(Cl)(Cl)(Cl)Cl>>CC(=O)N1C(=O)C(=C(Cl)c2ccccc2)c2ccccc21,,Cc1ccccc1,,,,val
US20160024103A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(CC(=O)OC)c(O)cc12.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(CC(=O)OC)c(OS(=O)(=O)C(F)(F)F)cc12,CN(C)c1ccncc1,CN(C)C=O,,O,,val
US20080194576A1,CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(Cl)nc(-c3ccccc3)n2)CC1.c1c[nH]cn1>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(-n3ccnc3)nc(-c3ccccc3)n2)CC1,,C1CCOC1,,O,[H-].[Na+],val
US20150336979A1,COC(=O)c1ccc(O)cc1.O=C(NC1CCCCC1)N[C@H]1CO[C@H]2[C@@H]1OC[C@H]2O>>COC(=O)c1ccc(O[C@H]2CO[C@@H]3[C@@H](NC(=O)NC4CCCCC4)CO[C@H]23)cc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100029753A1,COC(=O)c1sccc1NS(=O)(=O)c1ccc(-n2cccn2)cc1>>O=C(O)c1sccc1NS(=O)(=O)c1ccc(-n2cccn2)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20090036492A1,CCC#CCBr.Cc1cc(O)cc(C)c1Br>>CCC#CCOc1cc(C)c(Br)c(C)c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US05256675,CC(=O)Nc1ncc(Sc2ccc([N+](=O)[O-])cc2)s1>>Nc1ncc(Sc2ccc([N+](=O)[O-])cc2)s1,,CC(=O)O,,Cl,,val
US20160272617A1,COCCOCCOCCOCCNC(=O)c1ccc(-c2ccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CNC(=O)OC(C)(C)C)CC3)C(=O)Nc3ccc4c(=O)[nH][nH]c4c3)cc2)c(C)c1.Cl>>COCCOCCOCCOCCNC(=O)c1ccc(-c2ccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CN)CC3)C(=O)Nc3ccc4c(=O)[nH][nH]c4c3)cc2)c(C)c1.Cl,,C1COCCO1,,,,val
US20080275069A1,Cc1ccc(S(=O)(=O)OCCF)cc1.Cn1c(-c2ccc(OCCCN3CCCCC3)cc2O)nc2cc(Br)ccc2c1=O>>Cn1c(-c2ccc(OCCCN3CCCCC3)cc2OCCF)nc2cc(Br)ccc2c1=O,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20150218172A1,CC(C)(C)n1ccc2cncnc21.O=C1CCC(=O)N1I>>CC(C)(C)n1cc(I)c2cncnc21,,CC#N,,,,val
US20150165026A1,C#CC(=O)O.Oc1ccc(-c2ccccc2)cc1>>C#CC(=O)Oc1ccc(-c2ccccc2)cc1,CN(C)c1ccncc1,CCOCC,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US06054448,CCOC(=O)CC(=O)C1CC(C(=O)OCC(=O)c2ccccc2)C1.OC1c2ccccc2Sc2ccc(Cl)cc21>>CCOC(=O)C(C(=O)C1CC(C(=O)OCC(=O)c2ccccc2)C1)C1c2ccccc2Sc2ccc(Cl)cc21,,CC(=O)O,CCO,,,val
US20030004181A1,CCCCCOC(=O)Cl.COC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C)c1ccccn1>>CCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OC)c4ccccn4)ccc3n2C)cc1,,CO,ClCCl,Cl,,val
US20070249670A1,C1CCOC1.COC(=O)[C@@H](NC(=O)c1ccc(-c2ccc(OC)cc2)cc1NC(=O)Nc1c(C)cc(C2CC2)cc1C)[C@@H](C)OC(C)(C)C>>COc1ccc(-c2ccc(C(=O)N[C@H](C(=O)O)C3CCCCC3)c(NC(=O)Nc3c(C)cc(C4CC4)cc3C)c2)cc1,,C1CCOC1,,[Li+].[OH-],,val
US20150259353A1,COc1ccc(Cn2c(=O)n(C)c(=O)c3c[nH]nc32)cc1.Fc1cccc(-c2ccc(CCl)cc2)n1>>COc1ccc(Cn2c(=O)n(C)c(=O)c3cn(Cc4ccc(-c5cccc(F)n5)cc4)nc32)cc1,,O,,CC(=O)N(C)C,O=C([O-])[O-].[K+].[K+],val
US04937252,COc1ccc(CNCCS)cc1.O=C(Oc1ccccc1)Oc1ccccc1>>COc1ccc(CN2CCSC2=O)cc1,,CCO,,,,val
US20110053916A1,CC(=O)n1nc(Nc2nc(-c3ccccc3)ncc2B2OC(C)(C)C(C)(C)O2)cc1C1CC1.OO>>Oc1cnc(-c2ccccc2)nc1Nc1cc(C2CC2)[nH]n1,,C1CCOC1,,O,,val
US06884868B1,C1CCC(OC2CCNCC2)CC1.N#Cc1ccc(F)cc1>>N#Cc1ccc(N2CCC(OC3CCCCC3)CC2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20140213554A1,O=[N+]([O-])c1cnc2sc(-c3ccccc3)nc2c1>>Nc1cnc2sc(-c3ccccc3)nc2c1,[Fe],CO,Cl,,,val
US05547919,CC(C)(C)ON=O.COC(=O)Cc1c(Oc2cccc(C(C)C)c2)nc(C)nc1N(C)C>>COC(=O)C(=NO)c1c(Oc2cccc(C(C)C)c2)nc(C)nc1N(C)C,,COCCOC,,,,val
US04540705,CS(=O)(=O)Cl.Cc1c(CO)ccc2ccccc12>>Cc1c(CCl)ccc2ccccc12,,ClCCl,,CCN(CC)CC,,val
US20110178060A1,CC(C)(C)OC(=O)N1C[C@@H](C(=O)O)[C@H](c2ccc(F)cn2)C1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N1C[C@@H](N)[C@H](c2ccc(F)cn2)C1,,Cc1ccccc1,,CCN(CC)CC,[Na+].[OH-],val
US04080455,O=c1[nH]c(Cl)ncc1F.Oc1ccccc1>>O=c1[nH]c(Oc2ccccc2)ncc1F,,Cc1ccccc1,,[K],,val
US20120190666A1,CSc1cc(-n2nc(C)cc2Nc2cccc3[nH]ncc23)nc(C)n1.O=C(OO)c1cccc(Cl)c1>>Cc1cc(Nc2cccc3[nH]ncc23)n(-c2cc(S(C)=O)nc(C)n2)n1,,CN(C)C=O,ClCCl,,,val
US05254564,CC1(C)CNC(CN2CCCC2)c2ccccc21.O=C(Cl)Cc1ccc(C(F)(F)F)cc1>>CC1(C)CNC(CN2CCCC2)(C(=O)Cc2ccc(C(F)(F)F)cc2)c2ccccc21,,ClC(Cl)Cl,,O=C([O-])[O-].[K+].[K+],,val
US20070249686A1,CCOC(=O)CBr.Oc1cccnc1Br>>CCOC(=O)COc1cccnc1Br,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090227570A1,C1COCCN1.CSC(=N)Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1>>N=C(Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1)N1CCOCC1,,CCO,,I,,val
US20070203159A1,COc1ccc(Cn2cnc3c(-c4ccco4)nc(C#C[Si](C)(C)C)nc32)cc1>>C#Cc1nc(-c2ccco2)c2ncn(Cc3ccc(OC)cc3)c2n1,,CO,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20040167121A1,NC(=O)c1cc(N2CCCCC2)ccc1[N+](=O)[O-]>>NC(=O)c1cc(N2CCCCC2)ccc1N,[Pd],CO,ClCCl,,,val
US20030181726A1,COC(=O)Nc1ccc(C(CCNCc2ccccc2)c2ccc(NC(=O)OC)cc2)cc1.c1ccc(OC[C@@H]2CO2)cc1>>COC(=O)Nc1ccc(C(CCNC[C@H](O)COc2ccccc2)c2ccc(NC(=O)OC)cc2)cc1,[Pd],C1COCCO1,CO,CCO,Cl,val
US20150291563A1,CC(C)(C)OC(=O)N1CC=C(c2ccc(C3CC(C(F)(F)C(F)(F)F)=NN3c3ccccc3Cl)cc2)CC1.O=C(O)C(F)(F)F>>FC(F)(F)C(F)(F)C1=NN(c2ccccc2Cl)C(c2ccc(C3=CCNCC3)cc2)C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20160002225A1,CC(C)(C)OC(=O)CC#N.O=Cc1cccc([N+](=O)[O-])c1>>CC(C)(C)OC(=O)/C(C#N)=C/c1cccc([N+](=O)[O-])c1,C1CCNCC1,CCO,,,,val
US20030191126A1,CCI.O=C(Cc1ccccc1Cl)N1CCC(Cc2cc(O)ccc2Br)CC1>>CCOc1ccc(Br)c(CC2CCN(C(=O)Cc3ccccc3Cl)CC2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070232583A1,CC(=O)OC(C)=O.Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(N)(=O)=O)c3)n2)n1>>CC(=O)NS(=O)(=O)c1cccc(-c2cccc(-c3cc(-c4ccc(C(F)(F)F)cc4)cc(C)n3)n2)c1,,CC(=O)O,CCOC(C)=O,,,val
US04169947,C[Si](C)(C)NC(=O)c1ccco1.O=C(Cl)C(=O)Cl>>O=C(Cl)C(=O)NC(=O)c1ccco1,,ClCCl,,,,val
US05322952,C=CCOC(=O)N1C[C@@H]2C[C@H]1C(=O)S2.CNC>>C=CCOC(=O)N1C[C@@H](S)C[C@H]1C(=O)N(C)C,,C1CCOC1,,,,val
US20120149691A1,N#Cc1cnn2cccc2c1NC1CCOCC1.OO>>NC(=O)c1cnn2cccc2c1NC1CCOCC1,,CCO,,[NH4+].[OH-],,val
US20140135318A1,CCCCN(CCCC)C(=O)c1c[nH]c(-c2ccc(C(=O)OC)cc2C(=O)OCc2ccccc2)n1.ClCCBr>>CCCCN(CCCC)C(=O)c1cn(CCCl)c(-c2ccc(C(=O)OC)cc2C(=O)OCc2ccccc2)n1,,CC#N,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140171403A1,NCCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1.O=C(O)Cc1c[nH]nn1>>O=C(Cc1c[nH]nn1)NCCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04775671,CC(N)=NO.O=C(O)c1ncn2c1[C@@H]1CCCN1C(=O)c1cc(F)ccc1-2>>Cc1noc(-c2ncn3c2[C@@H]2CCCN2C(=O)c2cc(F)ccc2-3)n1,,O,,CN(C)C=O,,val
US04774266,C=C(C)C(=O)OCC(O)CCl.c1ccc(-c2nnn[nH]2)cc1>>OCC(O)Cn1nnnc1-c1ccccc1,,COCCO,,[Na],,val
US04687775,COc1ccc2nc(S)[nH]c2c1.OCc1cccn2ccnc12>>COc1ccc2[nH]c(SCc3cccn4ccnc34)nc2c1,,Br,CC(=O)O,,,val
US20080261972A1,Cc1ccc[nH]c1=O.O=S(=O)(OCC(F)(F)F)C(Cl)(Cl)Cl>>Cc1cccn(CC(F)(F)F)c1=O,,ClCCl,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20120302762A1,Brc1ccc2c(c1)c1ccccc1n2-c1ccccc1.c1ccc(Nc2ccc(-c3ccccc3)cc2)cc1>>c1ccc(-c2ccc(N(c3ccccc3)c3ccc4c(c3)c3ccccc3n4-c3ccccc3)cc2)cc1,,CCCCCC,,CCOC(C)=O,,val
US20110105461A1,CN.Cc1ccc(S(=O)(=O)OCC2COc3ccc(S(C)(=O)=O)cc3O2)cc1>>CNCC1COc2ccc(S(C)(=O)=O)cc2O1,,CC#N,,Cl,,val
US06586430B1,CCOC(CBr)OCC.CCOC(CO)OCC>>CCOC(COCC(OCC)OCC)OCC,,Cc1ccccc1C,,[H-].[Na+],,val
US05824690,COc1ccc(C(=O)[C@@](O)(C(=O)O)[C@](O)(C(=O)O)C(=O)c2ccc(OC)cc2)cc1.OCCC1(c2ccc(F)cc2)CCNC1>>COc1ccc(C(=O)[C@@](O)(C(=O)O)[C@](O)(C(=O)O)C(=O)c2ccc(OC)cc2)cc1.OCCC1(c2ccc(F)cc2)CCNC1,,CCC(C)=O,,CO,,val
US05738974,CN(C)C=O.Nc1ccccc1O>>O=Cc1ccccc1O,,O,,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US20150018363A1,CO.Cc1c(CCl)nc2ccc(I)cn12>>COCc1nc2ccc(I)cn2c1C,,CO,,C[O-].[Na+],,val
US20060287355A1,CCc1c(CO)cccc1Nc1c(C(N)=O)cnc(N)c1[N+](=O)[O-]>>CCc1c(CO)cccc1Nc1c(C(N)=O)cnc(N)c1N,[Pd],CO,,,,val
US20160060257A1,C[Si](C)(C)CCOCCl.Clc1ccnc2[nH]cc(I)c12>>C[Si](C)(C)CCOCn1cc(I)c2c(Cl)ccnc21,,C1CCOC1,,[H-].[Na+],,val
US20080275043A1,C=CCCC(=O)Cl.O=C1N[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1>>C=CCCC(=O)N1C(=O)O[C@H](c2ccccc2)[C@@H]1c1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20140024694A1,CC(C)(N)C(C)(C)O.C[Si](C)(C)C#Cc1c(F)ccc(C#N)c1Cl>>CC(C)(O)C(C)(C)n1ccc2c(Cl)c(C#N)ccc21,,CCOC(C)=O,O,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US20110195954A1,COC(=O)CC1CNc2cccc([N+](=O)[O-])c21>>COC(=O)CC1CNc2cccc(N)c21,[Ni],CO,,[H][H],,val
US05883262,CC(C)(C)C(=O)Oc1ccc(CBr)cc1Cl.c1cn[nH]n1>>CC(C)(C)C(=O)Oc1ccc(Cn2nccn2)cc1Cl,,CN(C)C=O,,[H][H],[H-].[Na+],val
US20050131017A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C[C@@H]1OC(C)(C)N(C(=O)OCc2ccccc2)[C@H]1Cc1ccc(OC(=O)C(F)(F)F)cc1.CCCC[Sn](CCCC)(CCCC)c1cccc(OC)n1>>COc1cccc(-c2ccc(C[C@H]3[C@H](C[C@H](Cc4ccccc4)NC(=O)OC(C)(C)C)OC(C)(C)N3C(=O)OCc3ccccc3)cc2)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,[Cl-].[Li+],,val
US20110137031A1,CCCC(N)CCC.Cc1cc(Cl)n2c(C#N)cc(-c3c(C)cc(Br)cc3C)c2n1>>CCCC(CCC)Nc1cc(C)nc2c(-c3c(C)cc(Br)cc3C)cc(C#N)n12,,CCO,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20160002263A1,C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OCC)c(C)nc3cc(C(=O)NCC(=O)Cc4cccc(Br)c4)nn23)CC1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OCC)c(C)nc3cc(-c4ncc(Cc5cccc(Br)c5)s4)nn23)CC1,,Cc1ccccc1,,,,val
US04737502,CC(=O)CCCCl.Cn1cnc2c1c(=O)[nH]c(=O)n2C>>CC(=O)CCCn1c(=O)c2c(ncn2C)n(C)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20020006948A1,CO.COc1cc2nc(-c3ccccc3)n(-c3ccc(C)cc3)c2cc1OCCCCCC(=O)O>>COC(=O)CCCCCOc1cc2c(cc1OC)nc(-c1ccccc1)n2-c1ccc(C)cc1,O=S(=O)(O)O,CO,O,O=C([O-])O.[K+],,val
US06583150B1,O=C1c2nccc(-c3ccccc3NC(=O)C(F)(F)F)c2C(=O)c2c([N+](=O)[O-])ccnc21>>O=C1c2nccc([N+](=O)[O-])c2-c2nc3ccccc3c3ccnc1c23,,ClCCl,,O=C(O)C(F)(F)F,,val
US06107342,COC(=O)[C@H]1[C@@H]2C[C@@H](O)[C@@](N=[N+]=[N-])(C(=O)OC)[C@H]12>>COC(=O)[C@H]1[C@@H]2CC(=O)[C@@](N=[N+]=[N-])(C(=O)OC)[C@H]12,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20090253699A1,COC(=O)c1cccc(-c2nc(-c3ccc(OC)cc3)n[nH]2)c1>>COc1ccc(-c2n[nH]c(-c3cccc(C(=O)O)c3)n2)cc1,,C1CCOC1,,[Na+].[OH-],,val
US20090198056A1,CN(c1cc(C=CC2CC2)cc(C(=O)O)c1)S(C)(=O)=O>>CN(c1cc(CCC2CC2)cc(C(=O)O)c1)S(C)(=O)=O,[Pd],CCOC(C)=O,,CO,,val
US20040259912A1,CC(C)(C)NC(=O)c1cc(N)ccc1OC(c1ccccc1)c1ccccc1.COc1ccc(N=C=O)cc1OC>>COc1ccc(NC(=O)Nc2ccc(OC(c3ccccc3)c3ccccc3)c(C(=O)NC(C)(C)C)c2)cc1OC,,C1CCOC1,,,,val
US05292747,Cn1cc(C2=C(c3c4n(c5ccccc35)C[C@@H]3CN(C(=O)OC(C)(C)C)C[C@@H]3C4)C(=O)OC2=O)c2ccccc21.O=C(O)C(F)(F)F>>Cn1cc(C2=C(c3c4n(c5ccccc35)C[C@@H]3CNC[C@@H]3C4)C(=O)OC2=O)c2ccccc21.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20080015191A1,COc1cc(Nc2cncc(Oc3ccc(N)cc3)n2)cc(OC)c1OC.O=C(Cl)c1ccc(Cl)cc1>>COc1cc(Nc2cncc(-c3ccc(C(=O)c4ccc(Cl)cc4)cc3N)n2)cc(OC)c1OC,,CCOC(C)=O,,,,val
US05155104,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.COc1cccc(C=O)c1.COc1cccc2c1C(=O)OC2.ClC(Cl)Cl>>COC(=O)/C=C/c1c(CO)cccc1OC.COc1cccc2c1C(O)OC2,,ClC(Cl)Cl,,,,val
US20120065214A1,Cc1cc(F)c(C(=O)NC2CC2)cc1-n1ccnc(NC2(c3ccccc3O)CC2)c1=O.ClCCBr>>Cc1cc(F)c(C(=O)NC2CC2)cc1-n1ccnc(NC2(c3ccccc3OCCCl)CC2)c1=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050261347A1,O=C(NCC1Cc2c(cccc2-c2ccccc2)O1)OCc1ccccc1>>NCC1Cc2c(cccc2-c2ccccc2)O1,,CCOCC,,Br,,val
US20130109662A1,C=C1CC(=O)O1.CC(C)N>>CC(=O)CC(=O)NC(C)C,,C1CCOC1,,,,val
US20160095844A1,CC(=N)N.CN1C(=O)C(C)(C)c2ccc(C(=O)CBr)cc21>>Cc1ncc(-c2ccc3c(c2)N(C)C(=O)C3(C)C)[nH]1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20070173519A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COCCOc1ccc(Nc2c(CCO[Si](C)(C)C(C)(C)C)c(Cl)nc3ccnn23)cc1>>COCCOc1ccc(N(C(=O)OC(C)(C)C)c2c(CCO[Si](C)(C)C(C)(C)C)c(Cl)nc3ccnn23)cc1,,C1COCCO1,,,,val
US20070299068A1,CCn1c(-c2ccc3[nH]ccc3c2)c(C#N)c2ccc(OC)cc21.CS(=O)(=O)Cl>>CCn1c(-c2ccc3c(ccn3S(C)(=O)=O)c2)c(C#N)c2ccc(OC)cc21,,O,c1ccncc1,,,val
US20060235024A1,CCC(C#Cc1cccc(Cl)c1)N1CCNCC1.COCCOC(=O)Cl>>CCC(C#Cc1cccc(Cl)c1)N1CCN(C(=O)OCCOC)CC1,,ClCCl,,CCN(CC)CC,,val
US20070259860A1,CC(C=NO)NC(=O)OC(C)(C)C.O=C1CCC(=O)N1Cl>>C[C@@H](NC(=O)OC(C)(C)C)/C(Cl)=N/O,,CN(C)C=O,,,,val
US20110319439A1,COc1cc(-n2ccc(SC)nc2=O)ccc1OCC(C)(C)O.OCc1ccc(Cl)cc1>>COc1cc(-n2ccc(OCc3ccc(Cl)cc3)nc2=O)ccc1OCC(C)(C)O,,CN1CCCC1=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US05278158,CC(=O)N1CC(C)(C)Oc2cc3nonc3cc21>>CC1(C)CNc2cc3nonc3cc2O1,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US20020028832A1,CC(C)(C)[Si](Oc1ccc(OC[C@@H](O)CNCCc2ccc(NC3CCN(C(=O)NCCCC4CCCCC4)CC3)cc2)cc1)(c1ccccc1)c1ccccc1>>O=C(NCCCC1CCCCC1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1,,CO,ClC(Cl)Cl,,,val
US20040058964A1,O=c1c(Br)c(C#Cc2ccccc2)ccn1Cc1ccccc1>>O=c1c(Br)c(CCc2ccccc2)ccn1Cc1ccccc1,O=[Pt],CCO,,CCOC(C)=O,[H][H],val
US20140073627A1,COc1cc(C)c(S(=O)(=O)N(C)Cc2cc(C(=O)O)co2)c(C)c1.c1cc(CN2CCNCC2)ccn1>>COc1cc(C)c(S(=O)(=O)N(C)Cc2cc(C(=O)N3CCN(Cc4ccncc4)CC3)co2)c(C)c1,,ClCCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20020095041A1,Cc1noc(N)c1Br.O=S(=O)(Cl)c1ccc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)s1>>Cc1noc(NS(=O)(=O)c2ccc(-c3cc(C(F)(F)F)cc(C(F)(F)F)c3)s2)c1Br,,CO,ClC(Cl)Cl,,,val
US20150166483A1,COC(=O)c1cc(C(C)(C)C)cc(N)c1OC.COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Oc4ccccc4)c4ccccc34)n2)cc(OC)c1>>COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(C(=O)OC)c4OC)c4ccccc34)n2)cc(OC)c1,,CC(=O)OC(C)C,,CCN(CC)CC,,val
US03933794,CCC#CCN.FC(F)(F)c1ccc2c(c1)C(c1ccccc1)=NCC(=S)N2>>CCC#CCNC1=Nc2ccc(C(F)(F)F)cc2C(c2ccccc2)=NC1,,C1CCOC1,,,,val
US20040242901A1,F[P-](F)(F)(F)(F)F.Fc1ccc(-c2cccc3c2Sc2ccccc2[SH+]3)cc1.OCC(O)CO>>F[P-](F)(F)(F)(F)F.OCC(O)COc1ccc(-c2cccc3c2Sc2ccccc2[SH+]3)cc1,,ClCCl,,O,[K+].[OH-],val
US20020091261A1,NN.O=C1c2ccccc2C(=O)C1c1ccncn1>>O=c1[nH]nc(Cc2ccncn2)c2ccccc12,,CCO,,O,,val
US20060173008A1,CCn1nc(-c2ccccc2)c(C(C)=O)c([N+](=O)[O-])c1=O.Cc1cc(N)no1>>CCn1nc(-c2ccccc2)c(C(C)=O)c(Nc2cc(C)on2)c1=O,,CCO,,,,val
US04150135,CN1C(=O)C[C@]2(c3ccccc3)CCCC[C@@H]2C1=O>>CN1CC[C@]2(c3ccccc3)CCCC[C@@H]2C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100317680A1,CN(C)C(=O)CCl.O=[N+]([O-])c1cn[nH]c1>>CN(C)C(=O)Cn1cc([N+](=O)[O-])cn1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090275570A1,N#CCc1ccsc1.O=CC(=O)O>>N#C/C(=C\C(=O)O)c1ccsc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20100137305A1,CC(C)(C)OC(=O)N1CCC(C)(C(=O)O)CC1.CCOC(=O)Cl.[N-]=[N+]=[N-]>>CC1(N=C=O)CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20160152609A1,C=C(C)Cc1cc2c(cc1O)CCC(=O)N2>>CC(C)Cc1cc2c(cc1O)CCC(=O)N2,[Pd],CCO,CCOC(C)=O,,,val
US20120101080A1,O=C(Cl)CCCc1ccccc1.c1ccc(CC2CNC2)cc1>>O=C(CCCc1ccccc1)N1CC(Cc2ccccc2)C1,,ClCCl,,CCN(CC)CC,,val
US04180522,CCC(=O)OC(=O)CC.CN(C)CCCCCNc1ccc(Cl)c(Cl)c1>>CCC(=O)N(CCCCCN(C)C)c1ccc(Cl)c(Cl)c1,,O,,,,val
US20110288065A1,CC(C)Br.Ic1cn[nH]c1>>CC(C)n1cc(I)cn1,,CN(C)C=O,,O,[H-].[Na+],val
US20140200227A1,CC(C)(C)OC(=O)N[C@H]1CCCN(c2c([N+](=O)[O-])cnc3ccccc23)C1>>CC(C)(C)OC(=O)N[C@H]1CCCN(c2c(N)cnc3ccccc23)C1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20030149016A1,CCCC[Sn](Cl)(CCCC)CCCC.Cc1nc(C(=O)CO[Si](C)(C)C(C)(C)C)c2sccn12>>CCCC[Sn](CCCC)(CCCC)c1cn2c(C)nc(C(=O)CO[Si](C)(C)C(C)(C)C)c2s1,,C1CCOC1,CN(C)P(=O)(N(C)C)N(C)C,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20080004348A1,CC(=O)OC(C)=O.COC(=O)CC(C#N)c1cccc2ccc(OC)cc12>>COC(=O)CC(CNC(C)=O)c1cccc2ccc(OC)cc12,[Ni],O,,[H][H],,val
US20080058350A1,COC(=O)c1ccn2ccnc2c1.O=C1CCC(=O)N1I>>COC(=O)c1ccn2c(I)cnc2c1,,CC#N,,,,val
US20110294780A1,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC.NCCO>>COC(=O)N1CCNS1(=O)=O,,C1CCOC1,,,,val
US06552225B1,COc1ccc(N)cn1.C[C@@](O)(C(=O)Nc1ccc(S(=O)(=O)Cl)c(Cl)c1Cl)C(F)(F)F>>COc1ccc(NS(=O)(=O)c2ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c(Cl)c2Cl)cn1,,ClCCl,,c1ccncc1,,val
US20020132812A1,BrBr.Cc1cccnc1C(CC1=NCCN1)c1cccc2c1OCC2>>Cc1cccnc1C(CC1=NCCN1)c1cc(Br)cc2c1OCC2,,ClCCl,,CC(=O)O,,val
US20120053171A1,CC(C)(C)OC(=O)NNC(=O)CC(CCBr)c1cccc(C(F)(F)F)c1>>NNC(=O)CC(CCBr)c1cccc(C(F)(F)F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05256675,CC(=O)Nc1ncc(Sc2ccc(N)cc2)s1.O=C(OO)c1cccc(Cl)c1>>CC(=O)Nc1ncc(S(=O)c2ccc(N)cc2)s1,,CN(C)C=O,ClCCl,,,val
US20160002221A1,COc1ccc(-c2cc3nccnc3c(OC[C@@H]3CNCCO3)n2)cc1OC.C[Si](C)(C)N=C=O>>COc1ccc(-c2cc3nccnc3c(OC[C@@H]3CN(C(N)=O)CCO3)n2)cc1OC,,ClCCl,,CCN(CC)CC,,val
US20130085148A1,CC(=O)C#N.O=c1oc(-c2ccc(F)cc2)ns1>>CC(=O)c1nc(-c2ccc(F)cc2)ns1,,Cc1ccccc1,,,,val
US20050059650A1,CCC(O)CC.CS(=O)(=O)c1ccc(-n2ncc3c(OC4CCNCC4)ncnc32)cc1.O=C(n1ccnc1)n1ccnc1>>CCC(CC)OC(=O)N1CCC(Oc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2)CC1,,CS(C)=O,,CCN(CC)CC,,val
US06175007B1,Cc1nc(-c2ccc(Cl)c([N+](=O)[O-])c2)c(Cl)n1C(F)F>>Cc1nc(-c2ccc(Cl)c(N)c2)c(Cl)n1C(F)F,[Fe],CC(=O)O,CO,CCOC(C)=O,O,val
US20010029239A1,COC=C(Oc1cccc(CBr)c1C(=O)OC(C)(C)C)C(=O)OC.Oc1ccccc1>>COC=C(Oc1cccc(COc2ccccc2)c1C(=O)OC(C)(C)C)C(=O)OC,,CC#N,,[I-].[K+],,val
US20100190764A1,C=CCC1(CC=C)C(=O)c2cc(F)ccc2Cc2ccccc21>>O=C1c2cc(F)ccc2Cc2ccccc2C12CC=CC2,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,ClCCl,,,,val
US20060194795A1,Cc1cc(N)ccc1N1C(=O)c2ccc(Cl)cc2C1=O.S=C(Cl)Cl>>Cc1cccc(N2C(=O)c3ccc(Cl)cc3C2=O)c1.[N-]=C=S,,CC(C)=O,,,,val
US20160000784A1,NO.O=Cc1cc(Br)cnc1F>>ON=Cc1cc(Br)cnc1F,,CO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20160009662A1,COc1ccc(F)c(B(O)O)c1.Nc1nc(Br)cnc1Br>>COc1ccc(F)c(-c2ncc(Br)nc2N)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20040002526A1,COC(=O)c1ccc(-c2ccc(C=O)o2)cc1.O=C1CSC(=O)N1>>COC(=O)c1ccc(-c2ccc(C=C3SC(=O)NC3=O)o2)cc1,C1CCNCC1,CCO,,,,val
US20150111837A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)O>>N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)O,,C1COCCO1,Cl,CCOCC,,val
US20140243309A1,Brc1cncc(Br)c1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>Cn1cc(-c2cncc(Br)c2)cn1,,C1COCCO1,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US05684030,Clc1ccc(CBr)cc1Cl.O=[N+]([O-])c1ccc2[nH]c(S)nc2c1>>O=[N+]([O-])c1ccc2[nH]c(SCc3ccc(Cl)c(Cl)c3)nc2c1,,CCO,,,,val
US20150175599A1,COc1ccc(N)cc1F.NN>>COc1ccc(NN)cc1F,,O,,Cl,,val
US20120196833A1,NC=O.Nc1ccc(I)cc1C(=O)O>>O=c1[nH]cnc2ccc(I)cc12,,O,,,,val
US20100286390A1,C[C@H]1[C@H](Nc2cnn(C[C@@H]3CO3)c(=O)c2Cl)C[C@@H]2C[C@H]1C2(C)C.NCc1ccncc1>>C[C@H]1[C@H](Nc2cnn(C[C@@H](O)CNCc3ccncc3)c(=O)c2Cl)C[C@@H]2C[C@H]1C2(C)C,,CCO,,,,val
US04915491,C=C(C)C(=O)Cl.O=[N+]([O-])c1ccc(C=Cc2ccc(OCCCCCCO)cc2)cc1>>C=C(C)C(=O)OCCCCCCOc1ccc(C=Cc2ccc([N+](=O)[O-])cc2)cc1,,CCN(CC)CC,,C1COCCO1,,val
US04611080,CCO.O=C(C=C(Cl)Cl)c1cc(F)c(F)cc1F.O=S(=O)(O)O>>CCOC(=O)CC(=O)c1cc(F)c(F)cc1F,,ClCCl,,[Na],,val
US20150376136A1,CC1(C2CCCC2)NC(=O)NC1=O.O=C(CBr)c1ccccc1>>CC1(C2CCCC2)NC(=O)N(CC(=O)c2ccccc2)C1=O,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090004185A1,Clc1nc(Cl)c2ccccc2n1.NCc1ccc(NC(=O)c2ccc(F)cc2)cc1>>O=C(Nc1ccc(CNc2nc(Cl)nc3ccccc23)cc1)c1ccc(F)cc1,,ClCCl,,CCN(CC)CC,,val
US20100331306A1,CC(NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2c(CO)c1-c1ccccc1.CS(=O)(=O)Cl>>CC(NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2c(COS(C)(=O)=O)c1-c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20070167433A1,CI.COCCCN1CCOc2ccc(COC3CN(C(=O)OCc4ccccc4)CC(NC(=O)OCc4ccccc4)C3c3ccc(OC4CCN(c5cccc(F)c5)C4)cc3)cc21>>COCCCN1CCOc2ccc(COC3CN(C(=O)OCc4ccccc4)CC(N(C)C(=O)OCc4ccccc4)C3c3ccc(OC4CCN(c5cccc(F)c5)C4)cc3)cc21,,CN(C)C=O,,[H-].[Na+],,val
US04116981,CC(C)CCON=O.COCCOC.Nc1ccccc1C(=O)O>>C1=CC2OC1c1ccccc12,,COCCOC,,[Na+].[OH-],,val
US20040053908A1,CC(C)(C)OC(=O)N1CCC(C(=O)Nc2cc(Oc3ccc(NC(=O)Oc4ccccc4)c(Cl)c3)ccn2)CC1.Nc1ccccc1>>CC(C)(C)OC(=O)N1CCC(C(=O)Nc2cc(Oc3ccc(NC(=O)Nc4ccccc4)c(Cl)c3)ccn2)CC1,,O,,CN(C)C=O,,val
US04100295,CC1(C)OCCOC1=NO.CN=C=O>>CNC(=O)ON=C1OCCOC1(C)C,CCN(CC)CC,,,,,val
US20100310493A1,CCOC(=O)C(Br)c1ccc(S(=O)(=O)N2CCCCC2)cc1.Oc1ccc(F)cc1F>>CCOC(=O)C(Oc1ccc(F)cc1F)c1ccc(S(=O)(=O)N2CCCCC2)cc1,,CC#N,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090306041A1,CC(C)(C)c1ccc2c(=O)c(-c3cccc(B4OC(C)(C)C(C)(C)O4)c3)c[nH]c2c1.Cn1cc(Br)cc(Nc2ccc(C(=O)N3CCOCC3)cn2)c1=O>>Cn1cc(-c2cccc(-c3c[nH]c4cc(C(C)(C)C)ccc4c3=O)c2)cc(Nc2ccc(C(=O)N3CCOCC3)cn2)c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US05028603,CC(C)(C)C(=O)Cl.Cc1nnc2n1-c1sc(C(C)O)cc1C(c1ccccc1Cl)=NC2>>Cc1nnc2n1-c1sc(C(C)OC(=O)C(C)(C)C)cc1C(c1ccccc1Cl)=NC2,,c1ccncc1,,,,val
US20020115666A1,CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(OS(C)(=O)=O)c1ccccc1.CNC(=O)NC1CCNCC1>>CNC(=O)NC1CCN(C(C(=O)N(C)CCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1,,CC(C)=O,,CCN(CC)CC,,val
US20080045742A1,CO.OCC=Cc1ccccc1>>COC(=O)C=Cc1ccccc1,,CO,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20120285538A1,CCCCC1(CCCC)c2cc(N)ccc2-c2ccc(Br)cc21.ICCCCCI>>CCCCC1(CCCC)c2cc(Br)ccc2-c2ccc(N3CCCCC3)cc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110207935A1,COC(=O)c1ccc(B(O)O)cc1.N#Cc1cc(Br)cc2ccccc12>>COC(=O)c1ccc(-c2cc(C#N)c3ccccc3c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20120309746A1,COC(OC)N(C)C.NO.Nc1ncc(I)cc1Br>>ON/C=N/c1ncc(I)cc1Br,,CC(C)O,,Cl,O=C([O-])O.[Na+],val
US04950666,COC(=O)CCCCCCCCCC=C(F)F>>O=C(O)CCCCCCCCCC=C(F)F,O,O,,Cl,[Na+].[OH-],val
US20150011528A1,CCC(Br)C(=O)OC.Cc1ccc(C(=O)Nc2nc3ccc(Br)cc3s2)cc1>>CCC(C(=O)OC)n1c(=NC(=O)c2ccc(C)cc2)sc2cc(Br)ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150105317A1,CC(CC(=O)O)[C@@H]1O[C@@H](C)[C@@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1>>C[C@@H]1O[C@@H](CCCCO)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@@H]1OCc1ccccc1,,C1CCOC1,,,,val
US04574060,CCOP([O-])c1ccccc1.Cc1ccc([Mg]Br)cc1>>Cc1ccccc1-c1ccc([PH2]=O)cc1,,CCOCC,,O=S(=O)(O)O,,val
US20090069340A1,COc1c(C)n(C)n(C2CCCC2)c1=O.O=C1CCC(=O)N1Br>>COc1c(CBr)n(C)n(C2CCCC2)c1=O,,ClC(Cl)(Cl)Cl,,,,val
US20100249123A1,CC(C)(C#N)c1ccc([N+](=O)[O-])cc1C(F)(F)F>>CC(C)(C#N)c1ccc(N)cc1C(F)(F)F,[Pd],CO,,,,val
US20050203108A1,COC(=O)c1ccc(CN(C(=O)OC(C)(C)C)[C@H]2CC[C@H](O)CC2)cc1>>COC(=O)c1ccccc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110112103A1,BrC(Br)(Br)Br.CC(C)(C)c1ccc(-c2ncc(CO)s2)cc1>>CC(C)(C)c1ccc(-c2ncc(CBr)s2)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090227640A1,Br.OCc1cc(F)ccc1OCCc1ccc(C(F)(F)F)cc1.c1ccc([PH+](c2ccccc2)c2ccccc2)cc1>>Fc1ccc(OCCc2ccc(C(F)(F)F)cc2)c(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1.[Br-],,CC#N,,,,val
US20030171341A1,COc1ccc(OC)c(S(=O)(=O)Cl)c1.NCc1ccccc1Cl>>COc1ccc(OC)c(S(=O)(=O)NCc2ccccc2Cl)c1,,CCOCC,,,,val
US20060235231A1,CCC=C(C)C(=O)OC.O=C1CCC(=O)N1Br>>COC(=O)C(C)=CC(C)Br,,ClC(Cl)(Cl)Cl,,,,val
US04954518,CS(=O)(=O)Nc1cc2oc(O)cc(=O)c2cc1Oc1ccccc1.O=[N+]([O-])O>>CS(=O)(=O)Nc1cc2oc(O)c([N+](=O)[O-])c(=O)c2cc1Oc1ccccc1,,CC(=O)O,,,,val
US20080119488A1,CCOC(=O)CBr.Cc1ccc(Cn2c(-c3cccc(-c4cccc(O)c4)c3)cc(C(F)(F)F)c(C#N)c2=O)c(C)c1>>CCOC(=O)COc1cccc(-c2cccc(-c3cc(C(F)(F)F)c(C#N)c(=O)n3Cc3ccc(C)cc3C)c2)c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120004218A1,N#Cc1ccc(N)cn1.O=Cc1ccc(F)c(Cl)c1>>N#Cc1ccc(N=Cc2ccc(F)c(Cl)c2)cn1,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,,,val
US20070167413A1,COC(C)=C(C#N)C#N.NNc1nc(C(F)(F)F)nc(-c2ccccc2)c1-c1ccccc1>>Cc1nn(-c2nc(C(F)(F)F)nc(-c3ccccc3)c2-c2ccccc2)c(N)c1C#N,,CO,,,,val
US06479531B1,CCOC(=O)c1cc(-c2ccccc2)[nH]c1CC12CC3CC(CC(C3)C1)C2.CI>>CCOC(=O)c1cc(-c2ccccc2)n(C)c1CC12CC3CC(CC(C3)C1)C2,,CN(C)C=O,,[H-].[Na+],,val
US20110064892A1,Cc1cc(N)c(N)cn1.Cc1cc2c3c(cc(C)cc3c1)C(=O)C2=O>>Cc1cc2c3c(cc(C)cc3c1)-c1nc3cc(C)ncc3nc1-2,,CC(=O)O,,,,val
US05221671,C#CCCOC(=O)N1CCc2c(sc(N)c2C(=O)c2ccccc2Cl)C1.CC(Br)C(=O)Br>>C#CCCOC(=O)N1CCc2c(sc(NC(=O)C(C)Br)c2C(=O)c2ccccc2Cl)C1,,C1COCCO1,,O,c1ccncc1,val
US20130109701A1,COc1cc(O)ccc1C=O.Clc1ccc(CBr)cc1Cl>>COc1cc(OCc2ccc(Cl)c(Cl)c2)ccc1C=O,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20010051620A1,COc1cc2cc3c(=O)c(C#N)c[nH]c3cc2cc1OCCN1CCOCC1.O=P(Cl)(Cl)Cl>>COc1cc2cc3c(Cl)c(C#N)cnc3cc2cc1OCCN1CCOCC1,,Cc1ccccc1,,,,val
US20110166123A1,CCOC(=O)c1cn([C@@H](C(C)C)C(C)(C)O[SiH2]C(C)(C)C)c2nc(OC)c(Cc3cccc(Cl)c3F)cc2c1=O>>COc1nc2c(cc1Cc1cccc(Cl)c1F)c(=O)c(C(=O)O)cn2[C@H](CO)C(C)C,,CO,O,C[O-].[Na+],,val
US20130310419A1,CC1(C)CCOc2c(F)cc(C(=O)CBr)cc21.CCC(=O)CC(C)=O>>CCC(=O)C(CC(=O)c1cc(F)c2c(c1)C(C)(C)CCO2)C(C)=O,,Cc1ccccc1,,O,[Na],val
US20020072525A1,CC(C)(C)OC(=O)N1CC2CC(C1)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc12>>CC(C)(C)OC(=O)N1CC2CC(C1)c1cc(N)c(N)cc12,[Pd],CO,,,,val
US05171354,CI.ON=C(Cc1cccnc1)c1ccc(F)cc1F>>CO/N=C(\Cc1cccnc1)c1ccc(F)cc1F,,COCCOC,,[H-].[Na+],,val
US20100233617A1,O=S(=O)(F)C(F)(F)C(F)(F)C(F)(F)S(=O)(=O)F>>O=S(=O)(F)C(F)(F)C(F)(F)C(F)F,,C1CCOC1,,CCN(CC)CC,CCOC(C)=O,val
US20150291572A1,CSc1cnc(C2CC(C)(S(=O)(=O)c3cccc(OC(F)F)c3)CCO2)c(Cl)c1.O=S([O-])OO>>CC1(S(=O)(=O)c2cccc(OC(F)F)c2)CCOC(c2ncc(S(C)(=O)=O)cc2Cl)C1,,CO,,O,,val
US20040229949A1,CCOC(=O)C(Cc1ccc(OCCc2ccc(O)cc2)cc1)OCC.O=S(=O)(Cl)Cc1ccccc1>>CCOC(=O)C(Cc1ccc(OCCc2ccc(OS(=O)(=O)Cc3ccccc3)cc2)cc1)OCC,,ClCCl,,CCN(CC)CC,O,val
US20090030015A1,COC(=O)c1cccc(-c2ccc(OC)cc2OC)c1>>COc1ccc(-c2cccc(C(=O)O)c2)c(OC)c1,,CC#N,,Cl,[Li+].[OH-],val
US06355638B1,NN.O=C1OC=C(O)C1c1ccccc1>>O=C1N=NC(CO)=C1c1ccccc1,,CCO,,O,,val
US20070004772A1,CI.O=c1n(Cc2ccc(C(F)(F)F)nc2CO)nc2c(-c3ccncc3)c(-c3ccc(Cl)cc3)ccn12>>COCc1nc(C(F)(F)F)ccc1Cn1nc2c(-c3ccncc3)c(-c3ccc(Cl)cc3)ccn2c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20110245205A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@H](C)Cc1ncc(-c2cc(C)cc(Nc3nccc(C(F)(F)F)n3)c2)s1>>COC(=O)[C@H](C)Cc1ncc(-c2cc(C)cc(N(C(=O)OC(C)(C)C)c3nccc(C(F)(F)F)n3)c2)s1,CN(C)c1ccncc1,C1CCOC1,O,CCN(CC)CC,,val
US06177423B1,CN(C)CCCl.O=C1c2cccc3cc(O)cc(c23)C(=O)N1OCc1ccccc1>>CN(C)CCOc1cc2c3c(cccc3c1)C(=O)N(OCc1ccccc1)C2=O,,CC(C)=O,,Cl,[I-].[K+],val
US20060142286A1,Cl[Mg]C1CCCCC1.ON1CCCCC1>>ON1CCCCC1C1CCCCC1,O=[Mn]=O,ClCCl,,[Cl-].[NH4+],,val
US20150112058A1,COP(=O)(CC(=O)OC(C)(C)C)OC.O=Cc1c(F)ccc(Cl)c1F>>CC(C)(C)OC(=O)/C=C/c1c(F)ccc(Cl)c1F,,C1CCOC1,CCOC(C)=O,CC(C)(C)[O-].[K+],,val
US20080076771A1,O=C(O)c1ccc(Nc2ccncn2)cc1.O=S(Cl)Cl>>Cl.O=C(Cl)c1ccc(Nc2ccncn2)cc1,,C1COCCO1,,,,val
US20100278833A1,CS(=O)(=O)OS(C)(=O)=O.NC(=O)c1sc(-n2cnc3cc(CO)ncc32)cc1OCc1ccccc1C(F)(F)F>>CS(=O)(=O)OCc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(C(N)=O)s3)c2cn1,,ClCCl,,CCN(CC)CC,,val
US20060287291A1,COc1ccc(C)cc1NS(=O)(=O)c1cc(C(=O)N2CCNC(C)C2)c2occc2c1.Cl>>COc1ccc(C)cc1NS(=O)(=O)c1cc(CN2CCNC(C)C2)c2occc2c1.Cl,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150175601A1,C=CC(=O)Cl.COc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1ncc2cccc(-c3cccc(N)c3)c2n1>>C=CC(=O)Nc1cccc(-c2cccc3cnc(Nc4ccc(N5CCN(C(=O)OC(C)(C)C)CC5)cc4OC)nc23)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20120214766A1,CC(C)(N)CO.O=C(O)c1nn(-c2cc(F)ccn2)c2c1C[C@H]1C[C@@H]21>>CC(C)(CO)NC(=O)c1nn(-c2cc(F)ccn2)c2c1C[C@H]1C[C@@H]21,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130317231A1,COc1ccc(/C=C/C(=O)c2cc(OC)c(OC)c(OC)c2)cc1OCC(=O)O.Nc1nc2ccc(OC(F)(F)F)cc2s1>>COc1ccc(/C=C/C(=O)c2cc(OC)c(OC)c(OC)c2)cc1OCC(=O)Nc1nc2ccc(OC(F)(F)F)cc2s1,,ClCCl,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20150307454A1,COC(=O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2C2CC2)cc1F.NN>>O=c1[nH][nH]c2cc(S(=O)(=O)N(Cc3ccc(OC(F)(F)F)cc3)c3ncc4ccccc4c3C3CC3)ccc12,,CCO,,CCOC(C)=O,O,val
US20070191457A1,COC(=O)c1cc(F)ccc1CBr.COc1ccc(N)cc1OCCN1CCCCC1.Cl>>COc1ccc(N2Cc3ccc(F)cc3C2=O)cc1OCCN1CCCCC1.Cl,,CN(C)C=O,,,,val
US20150218186A1,CSc1ncc2c(=O)[nH]cc(I)c2n1.Cn1cc(B(O)O)cn1>>CSc1ncc2c(=O)[nH]cc(-c3cnn(C)c3)c2n1,,CCOC(C)=O,O,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US05449840,CN(C)C=O.Nc1ncnc2nc[nH]c12>>Cc1nc(N)c2[nH]cnc2n1,,CN(C)C=O,,CCCCCC,[H-].[Na+],val
US20140315934A1,COC(=O)c1cc(OS(=O)(=O)C(F)(F)F)n(Cc2ccccc2)n1.OB(O)C1CC1>>COC(=O)c1cc(C2CC2)n(Cc2ccccc2)n1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20160024110A1,CCOC(OCC)OCC.COC(=O)CC(=O)CCl>>CCO/C(=C/C(=O)OC)CCl,O=S(=O)(O)O,ClC(Cl)Cl,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20160028021A1,CC(C)OB1OC(C)(C)C(C)(C)O1.c1ccc(-c2ccc(-c3cccc4c3[se]c3ccccc34)cc2)cc1>>CC1(C)OB(c2cccc3c2[se]c2c(-c4ccc(-c5ccccc5)cc4)cccc23)OC1(C)C,,C1CCOC1,,[Li]C(C)CC,,val
US20140256736A1,COc1ccc(CN(c2ncns2)S(=O)(=O)c2cc(F)c(F)cc2F)c(OC)c1.Oc1ccc(Cl)cc1-c1ccc2[nH]cnc2c1>>COc1ccc(CN(c2ncns2)S(=O)(=O)c2cc(F)c(Oc3ccc(Cl)cc3-c3ccc4[nH]cnc4c3)cc2F)c(OC)c1,,CN(C)C=O,,[H-].[Na+],,val
US04612318,Cc1nn(C)c(N)c1C1=CCC(C)CC1.O=CO>>Cc1nn(C)c(NC=O)c1C1=CCC(C)CC1,,O=CO,,CC(=O)OC(C)=O,,val
US20090186900A1,CCOC(=O)CBr.CCc1cc(-c2ccc3c(c2)CCC3=O)ccc1OC>>CCOC(=O)CC1Cc2cc(-c3ccc(OC)c(CC)c3)ccc2C1=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20070244131A1,COc1ccc(CCNc2cc(-c3ccc(F)c(C=NO)c3)nc(OC)n2)cc1.Cl>>COc1ccc(CCNc2cc(-c3ccc(F)c(CN)c3)nc(OC)n2)cc1.Cl,[Zn],CC(=O)O,CCOC(C)=O,,,val
US20100137425A1,O=c1c(Br)coc2ccccc12.OB(O)c1cccc(Cl)c1>>O=c1c(-c2cccc(Cl)c2)coc2ccccc12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US04198424,CCCCCC(=O)Cl.COc1cccc(C(O)CC2CCCN2C)c1>>CCCCCC(=O)OC(CC1CCCN1C)c1cccc(OC)c1,,ClCCl,,CCN(CC)CC,O,val
US20100087496A1,O=C(O)c1cc2cc(Cl)ccc2[nH]1.O=S(Cl)Cl>>O=C(Cl)c1cc2cc(Cl)ccc2[nH]1,CN(C)C=O,,,,,val
US20070225340A1,CC[C@H](C)CO.COC(=O)c1cccc(-c2ccccc2-c2cc(Br)ccc2O)n1>>CC[C@H](C)COc1ccc(Br)cc1-c1ccccc1-c1cccc(C(=O)OC)n1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060178510A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc(C[C@@H]2CNCCO2)cc1>>COc1ccc(C[C@@H]2CN(C(=O)OC(C)(C)C)CCO2)cc1,,ClCCl,,,,val
US05661166,CC1=CC2OC2C(C)(C)CC1=O.COc1ccc(CO)cc1>>COc1ccc(COC2C=C(C)C(=O)CC(C)(C)C2O)cc1,Cc1ccc(S(=O)(=O)O)cc1,C1CCOC1,,,,val
US20070105852A1,COC(=O)c1sc(N)c(C#N)c1-c1ccc(C(C)(C)C)cc1.ICI>>COC(=O)c1sc(I)c(C#N)c1-c1ccc(C(C)(C)C)cc1,,CC#N,,CC(C)CCON=O,,val
US20040122063A1,CC(C)(C)OC(=O)N[C@H]1C[C@H](C(C)(C)O)CC[C@H]1NC(=O)c1cc2cc(Cl)ccc2[nH]1.Cl>>CC(C)(O)[C@@H]1CC[C@@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](N)C1.Cl,,C1COCCO1,,CCO,,val
US06420343B1,C/C=C/C=O.c1cncc(-c2c[nH]cn2)c1>>CC(CC=O)n1cnc(-c2cccnc2)c1,,C1CCOC1,,CCO,,val
US20020077318A1,CC(C)(C)OC(=O)N1CCc2c(n(CC(=O)O)c3cc(Cl)c(Cl)cc23)CC1.COc1ccc(N)cc1>>COc1ccc(NC(=O)Cn2c3c(c4cc(Cl)c(Cl)cc42)CCN(C(=O)OC(C)(C)C)CC3)cc1,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,CC(C)N=C=NC(C)C,,val
US20160200686A1,COc1ccc(CC(NC(=O)OCc2ccccc2)c2nc3cncnc3[nH]2)cc1>>COc1ccc(CC(N)c2nc3cncnc3[nH]2)cc1,[Pd],C1CCOC1,,N#N,,val
US20120027874A1,CC(C)(O)CN.Nc1ncc(Br)nc1-c1cc(-c2ccc(CCl)cc2)no1>>CC(C)(O)CNCc1ccc(-c2cc(-c3nc(Br)cnc3N)on2)cc1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20100190745A1,CCOC(=O)c1cn([C@@H]2CCNC2)c2ccc(I)cc2c1=O.CI>>CCOC(=O)c1cn([C@@H]2CCN(C)C2)c2ccc(I)cc2c1=O,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US04539410,COc1ccc2[nH]cc(C)c2c1.c1c[nH]cn1>>COc1ccc2[nH]c(-n3ccnc3)c(C)c2c1,,C1COCCO1,CCOCC,BrBr,,val
US20100056576A1,C[C@H]1CN(c2ccncc2[N+](=O)[O-])C[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C>>C[C@H]1CN(c2ccncc2N)C[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C,[Pd],CCO,,,,val
US20070054924A1,COC(=O)c1ccc(Cl)c(C(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)c1cc(C(=O)O)ccc1Cl,,C1CCOC1,O,[Li+].[OH-],,val
US20110207713A1,CC(C)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=C3CN(C(=O)OC(C)(C)C)C3)ccc2n1>>CC(C)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CN(C(=O)OC(C)(C)C)C3)ccc2n1,,CO,,,,val
US20110009441A1,Nc1ccc(Br)cc1Cl.O=C1CCC2(CC1)OCCO2>>Clc1cc(Br)ccc1NC1CCC2(CC1)OCCO2,,CC(=O)O,ClCCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120322785A1,Cc1c(F)c[n+]([O-])c(C)c1Br>>Cc1c(F)cnc(CO)c1Br,,CCOC(C)=O,ClCCl,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20040110767A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=Cc1ccc(O)cc1>>Cc1ccc(S(=O)(=O)Oc2ccc(C=O)cc2)cc1,,ClCCl,O,CCN(CC)CC,Cl,val
US20110201604A1,CCn1c(Nc2nc3ccc(Cl)cc3s2)nc2cc(C(=O)O)ccc21.COC(C)(C)CN>>CCn1c(Nc2nc3ccc(Cl)cc3s2)nc2cc(C(=O)NCC(C)(C)OC)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050075378A1,Cc1oc(-c2ccccc2)nc1CCOc1ccc(CCC(=O)OC(C)(C)C)c(CBr)c1.Oc1ccc(C(F)(F)F)cc1>>Cc1oc(-c2ccccc2)nc1CCOc1ccc(CCC(=O)O)c(COc2ccc(C(F)(F)F)cc2)c1,,CCOCC,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20050256147A1,BrCC1CC1.O=S(=O)(Oc1ccc2c(c1)[C@@]13CCCC[C@H]1[C@@H](C2)NCC3)C(F)(F)F>>O=S(=O)(Oc1ccc2c(c1)[C@@]13CCCC[C@H]1[C@@H](C2)N(CC1CC1)CC3)C(F)(F)F,,ClCCl,,,,val
US20010018405A1,CCCNC(=O)c1ccsc1N.CCCOC(OCCC)(OCCC)OCCC>>CCCNC(=O)c1ccsc1N=C(OCCC)OCCC,,CCCO,,,,val
US20030013716A1,Nc1cc(-c2ccccc2)n[nH]c1=O.O=C1CCC(=O)N1Br>>Nc1c(Br)c(-c2ccccc2)n[nH]c1=O,,CC#N,,,,val
US06025495,CC(O)N1CCCCC1.ClCCl>>ClCCN1CCCCC1,,ClCCl,,Cc1ccc(S(=O)(=O)Cl)cc1,,val
US20010001799A1,CCOC(=O)C(Nc1ccc(C#N)cc1)c1cc(CO)cc(OCC)c1.CS(=O)(=O)Cl>>CCOC(=O)C(Nc1ccc(C#N)cc1)c1cc(COS(C)(=O)=O)cc(OCC)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20040048858A1,CCOC(=O)C(Br)(Br)C(=O)OCC.Oc1ccccc1O>>CCOC(=O)C1(C(=O)OCC)Oc2ccccc2O1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150175623A1,CC(C)OB1OC(C)(C)C(C)(C)O1.Cc1c(Br)ccc(O[Si](C(C)C)(C(C)C)C(C)C)c1Cl>>Cc1c(B2OC(C)(C)C(C)(C)O2)ccc(O[Si](C(C)C)(C(C)C)C(C)C)c1Cl,,C1CCOC1,,[Li]CCCC,,val
US04902710,C=O.CC(=O)c1ccccc1.CNCc1ccccc1.Cl>>CN(CCC(=O)c1ccccc1)Cc1ccccc1.Cl,,CCO,,,,val
US20130244993A1,C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O.O=c1cc(Br)ccn1C1COC1>>C[C@@H](c1ccc(-c2ccn(C3COC3)c(=O)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,COCCOC,O=C([O-])O.[Na+],,val
US20120135990A1,CC(C)(C)OC(=O)N1CC(OC(=O)c2ccc([N+](=O)[O-])cc2)C2C1CCN2C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N1CC(O)C2C1CCN2C(=O)OCc1ccccc1,,C1CCOC1,CO,[Na+].[OH-],,val
US04900833,CCOCN1C(C)=C(C(=O)O)[C@@H](c2cccc([N+](=O)[O-])c2)C(C(=O)OC)=C1C.CN(C)C=O>>C1CCC2=NCCCN2CC1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20140275016A1,C=C(C)OC(=O)Cl.COC1(C(N)=O)CCCC1>>C=C(C)OC(=O)NC(=O)C1(OC)CCCC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20090233897A1,BrCc1ccccc1Br.c1cncc(Cc2cccnc2)c1>>Brc1ccccc1CC(c1cccnc1)c1cccnc1,,C1CCCCC1,C1CCOC1,O,CC(C)[N-]C(C)C.[Li+],val
US20160264552A1,COC(=O)C1CNCC(C(=O)OC)C1.O=C(Cl)OCc1ccccc1>>COC(=O)C1CC(C(=O)OC)CN(C(=O)OCc2ccccc2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110174728A1,OCCCCCCCCCl>>CCCCCCCCCl,,C1CCOC1,,O=S(Cl)Cl,c1ccncc1,val
US06174901B1,CC(C)(CN=[N+]=[N-])Cc1ccccc1>>CC(C)(CN)Cc1ccccc1,[Pd],C1CCOC1,,CO,[H][H],val
US20120115856A1,NCc1ccccc1.O=[N+]([O-])c1cc(-c2nc3ccccc3o2)ccc1F>>O=[N+]([O-])c1cc(-c2nc3ccccc3o2)ccc1NCc1ccccc1,,CCO,,O,O=C([O-])O.[Na+],val
US20140038975A1,CCOC(=O)[C@@](C)(CCBr)S(C)(=O)=O.c1ccc2nc(-c3cn[nH]c3)cnc2c1>>CCOC(=O)[C@@](C)(CCn1cc(-c2cnc3ccccc3n2)cn1)S(C)(=O)=O,,CC#N,,[I-].[Na+],O=C([O-])[O-].[Cs+].[Cs+],val
US20080275056A1,CC(C)(C)OC(=O)N1CCC(Oc2ncc(N)c3ccccc23)CC1.Cc1ccc(-n2nc(C3(C)CC3)cc2NC(=O)OCC(Cl)(Cl)Cl)cc1>>Cc1ccc(-n2nc(C3(C)CC3)cc2NC(=O)Nc2cnc(OC3CCN(C(=O)OC(C)(C)C)CC3)c3ccccc23)cc1,,CS(C)=O,O,CCN(C(C)C)C(C)C,ClCCl,val
US20140135332A1,BrP(Br)Br.CC(O)c1nc(-c2ccc(Cl)cc2)ns1>>CC(Br)c1nc(-c2ccc(Cl)cc2)ns1,,Cc1ccccc1,,,,val
US20060074075A1,COc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>COc1ccc(N)cc1N,,CC#N,,,,val
US20020147302A1,COC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C>>CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C)C(=O)O,,CC(C)=O,O,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US20120108619A1,BrP(Br)Br.CCOC(=O)c1nn(C(C)(C)C)cc1CO>>CCOC(=O)c1nn(C(C)(C)C)cc1CBr,,ClCCl,,,,val
US05550149,COc1cc2c(cc1O[Si](C)(C)C(C)(C)C)CNCC2.COc1ccc(C(C#N)(CCCCCBr)SC2CCCCC2)cc1OC>>COc1cc2c(cc1O)CN(CCCCCC(C#N)(SC1CCCCC1)c1ccc(OC)c(OC)c1)CC2,,CC#N,,CCN(C(C)C)C(C)C,,val
US20110081409A1,CCOC(=O)c1ccc([N+](=O)[O-])c(F)c1.NCc1ccccc1>>CCOC(=O)c1ccc([N+](=O)[O-])c(NCc2ccccc2)c1,,CCOC(C)=O,CN(C)C=O,,,val
US20090270460A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)[Si](Oc1ccc(N)c(F)c1)(C(C)C)C(C)C>>CC(C)[Si](Oc1ccc(NC(=O)OC(C)(C)C)c(F)c1)(C(C)C)C(C)C,,C1CCOC1,,,,val
US20120009151A1,C1CCNC1.O=S(=O)(c1ccc(F)cc1)N1CCC(Nc2nc(Cl)nc(OCC(F)(F)F)n2)CC1>>O=S(=O)(c1ccccc1)N1CCC(Nc2nc(OCC(F)(F)F)nc(N3CCCC3)n2)CC1,,CC#N,O,CCN(C(C)C)C(C)C,,val
US20120129854A1,CC(C)(C)OC(=O)Nc1cccc2ncccc12.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)Nc1cccc2c1ccc[n+]2[O-],,ClCCl,,O=C([O-])O.[Na+],,val
US06071934,CC(C)N.CC1=C(CN=C=O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1>>CC1=C(CNC(=O)NC(C)C)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1,,CCCCCC,Cc1ccccc1,,,val
US20060009434A1,CC(=O)Oc1cc2c(cc1I)[C@H]1CC[C@]3(C)C(=O)CC[C@H]3[C@@H]1[C@@H](OC(C)=O)C2>>CC(=O)O[C@H]1Cc2cc(O)c(I)cc2[C@H]2CC[C@]3(C)C(=O)CC[C@H]3[C@H]12,,CO,,O=C([O-])O.[Na+],,val
US20100267561A1,BrBr.O=c1[nH]ncc(Cl)c1Cl>>O=c1[nH]nc(Br)c(Cl)c1Cl,,O,,,,val
US20150031685A1,COC(=O)C(NC(=O)OCc1ccccc1)P(=O)(OC)OC.O=C1CCOCC1>>COC(=O)C(NC(=O)OCc1ccccc1)=C1CCOCC1,,CCOC(C)=O,,CN(C)C(=N)N(C)C,,val
US20140200206A1,COc1cc(C(=O)Cl)ccc1[N+](=O)[O-].NC(CO)CO>>COc1cc(C(=O)NC(CO)CO)ccc1[N+](=O)[O-],,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20090156642A1,CCOC(=O)c1cc(O)n(-c2ccc(F)cc2F)n1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)c1cc(OS(=O)(=O)C(F)(F)F)n(-c2ccc(F)cc2F)n1,,C1CCOC1,,CCN(CC)CC,O,val
US20040092594A1,CCOC(=O)C=Cc1ccc(OC)c(-c2cc3c(cc2OCc2cccc(OCOC)c2)C(C)(C)CCC3(C)C)c1>>COc1ccc(C=CC(=O)O)cc1-c1cc2c(cc1OCc1cccc(O)c1)C(C)(C)CCC2(C)C,,CCO,,,,val
US20100016279A1,FC(F)(F)c1nnc2ccc(Cl)nn12.Oc1ccc(C2(O)CCNCC2)cc1>>Oc1ccc(C2(O)CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20160102091A1,CN(C)C=O.Cc1cc(C)c(-c2nc3c([nH]2)COCC3)cc1C(=O)N1CCC(c2ccc(OC(F)(F)F)cc2)CC1.Cc1cc(C2CCC2)c(C=O)cc1C(=O)O>>Cc1cc(C2CCC2)c(C=O)cc1C(=O)N1CCC(c2ccc(C#N)cc2)CC1,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,CCN=C=NCCCN(C)C,Cl,val
US20090053192A1,CC(=O)Cl.COc1ccc(NNC(=N)N)c(Cl)c1>>COc1ccc(-n2nc(N)nc2C)c(Cl)c1,,c1ccncc1,,Cl,Cl,val
US20110112096A1,Cc1cc(C2CCC3(CC2)OCCO3)c(C)cc1N.Cc1cc(Nc2nc(Cl)ncc2C(F)(F)F)n[nH]1>>Cc1cc(Nc2nc(Nc3cc(C)c(C4CCC(=O)CC4)cc3C)ncc2C(F)(F)F)n[nH]1,,CC(C)O,,CO,Cl,val
US20100004456A1,COC(=O)c1ccccc1CBr.Oc1ccc(Br)cc1>>COC(=O)c1ccccc1COc1ccc(Br)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05378840,Cl.O=C(NNC(=O)C(F)(F)C(O)c1ccccn1)N1Cc2ccccc2Oc2ccc(Cl)cc21>>Cl.O=C(NNC(=O)C(F)(F)C(O)c1ccccn1)N1Cc2ccccc2Oc2ccc(Cl)cc21,,O,,,,val
US20020119992A1,CC(NC(=O)OC(C)(C)C)c1ccc(Cl)cc1CO.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(NC(=O)OC(C)(C)C)c1ccc(Cl)cc1CN=[N+]=[N-],,Cc1ccccc1,,C1CCC2=NCCCN2CC1,,val
US20100216814A1,CC(=CBr)c1ccc(F)c(F)c1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>C/C(=C\n1c2c(c3cc(C)ccc31)CN(C)CC2)c1ccc(F)c(F)c1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20060142335A1,CCCCCCCNC(=O)Oc1ccc2c(c1)CCCN2Cc1ccccc1>>CCCCCCCNC(=O)Oc1ccc2c(c1)CCCN2,[Pd],CCO,,[H][H],,val
US20050234109A1,CC(C)(C)O.O=C(O)CCCC(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1.[N-]=[N+]=NP(=O)(Oc1ccccc1)Oc1ccccc1>>CC(C)(C)OC(=O)NCCCC(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1,,CCCCCC,ClCCl,CCN(CC)CC,Cc1ccccc1,val
US06800629B2,N.N#Cc1ncc[nH]c1=O>>N=C(N)c1ncc[nH]c1=O,,CO,,Cl,,val
US04218473,COC(=O)C(C)c1ccc(C2CCCCC2)c2ccccc12>>CC(C(=O)O)c1ccc(C2CCCCC2)c2ccccc12,,CCO,O,Cl,[K+].[OH-],val
US20100010053A1,CC(C)Oc1ccc(-c2nc(-c3cccc4c(CC=O)cn(C)c34)no2)cc1Cl.CCOC(=O)C1CCNCC1>>CCOC(=O)C1CCN(CCc2cn(C)c3c(-c4noc(-c5ccc(OC(C)C)c(Cl)c5)n4)cccc23)CC1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US06211234B1,Cc1ccccc1C(C)Oc1cc(OCc2ccccc2)ccc1C(=O)O.O=C(Cl)C(=O)Cl>>Cc1ccccc1C(C)Oc1cc(OCc2ccccc2)ccc1C(=O)Cl,,ClCCl,,,,val
US20160050924A1,CC(=O)C(=CN(C)C)C(=O)N(C)c1cccnc1.Cc1cc(Br)cnc1NN>>Cc1cc(Br)cnc1-n1ncc(C(=O)N(C)c2cccnc2)c1C,,CCO,,,,val
US20160200725A1,CC(C)(C)OC(=O)NC1CCN(CCOS(C)(=O)=O)CC1.COc1cc(OC)c(Cl)c(-c2cc3cnc(SC)nc3[nH]c2=O)c1>>COc1cc(OC)c(Cl)c(-c2cc3cnc(SC)nc3n(CCN3CCC(NC(=O)OC(C)(C)C)CC3)c2=O)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20090030082A1,COC(=O)Cc1cccc(OCCCN(Cc2cc(OC)cc(OC)c2)CC(c2ccccc2)c2ccccc2)c1>>COc1cc(CN(CCCOc2cccc(CC(=O)O)c2)CC(c2ccccc2)c2ccccc2)cc(OC)c1,,CO,,[Na+].[OH-],,val
US04474692,CCOC(=O)C(CCc1ccc(OC)c(OC)c1)N[C@@H](C)C(=O)N(CC(=O)O)C1Cc2ccccc2C1>>COc1ccc(CCC(N[C@@H](C)C(=O)N(CC(=O)O)C2Cc3ccccc3C2)C(=O)O)cc1OC,,CO,,Cl,[Na+].[OH-],val
US20150284395A1,CCOC(=O)CC(=O)c1ccc2cnn(CC)c2c1.Cc1noc(-c2cn[nH]c2N)n1>>CCn1ncc2ccc(-c3cc(=O)n4ncc(-c5nc(C)no5)c4[nH]3)cc21,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110082133A1,C1CCOC1.CN(C)C=O.COC(=O)c1ccc(CCn2c(C(=O)O)c(Cl)cc(Cl)c2=O)cc1.O=C(Cl)C(=O)Cl>>CCc1cccc(NC(=O)c2c(Cl)cc(Cl)c(=O)n2CCc2ccc(C(=O)OC)cc2)c1,,C1CCOC1,,,,val
US20120245144A1,CC(C)(C)OC(=O)N1CCNCC1.CC(C)n1ncnc1-c1cn2c(n1)-c1cc(S(=O)(=O)Cl)ccc1OCC2>>CC(C)n1ncnc1-c1cn2c(n1)-c1cc(S(=O)(=O)N3CCN(C(=O)OC(C)(C)C)CC3)ccc1OCC2,,ClCCl,,CCN(CC)CC,,val
US20100130495A1,COc1cc(Nc2nc3c(c(C(C)n4nc(C)cc4C)n2)CN(C(=O)OC(C)(C)C)CC3)ccc1-n1cnc(C)c1>>COc1cc(Nc2nc3c(c(C(C)n4nc(C)cc4C)n2)CNCC3)ccc1-n1cnc(C)c1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20150291562A1,CC1(C)[C@H](NC(=O)c2ccc(OCCCCCOCCCN)cc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1.O=C1CCC(N2C(=O)c3cccc(F)c3C2=O)C(=O)N1>>CC1(C)[C@H](NC(=O)c2ccc(OCCCCCOCCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)cc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,,C1COCCO1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20110257151A1,CC(C)(C)c1ccc(-c2cccc(C3Nc4ccc(F)c(C(=O)O)c4CC3(C)C)c2)cc1.NS(=O)(=O)C1CC1>>CC(C)(C)c1ccc(-c2cccc(C3Nc4ccc(F)c(C(=O)NS(=O)(=O)C5CC5)c4CC3(C)C)c2)cc1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20070037846A1,CCCOc1ccc(C=O)c(O)c1C.Cc1ccc(S(=O)(=O)OCC2COC(C)(C)O2)cc1>>CCCOc1ccc(C=O)c(OCC2COC(C)(C)O2)c1C,,CN(C)C=O,O,[I-].[K+],,val
US20150094296A1,CC[C@]1(C#N)CCN(c2ccnc(Cl)n2)C1=O.Cc1c(N)cnn1C>>CC[C@]1(C#N)CCN(c2ccnc(Nc3cnn(C)c3C)n2)C1=O,,CC(C)O,,Cl,Cl,val
US06444833B1,C=C(C)C(=O)O.Cc1sccc1-c1ccccc1>>Cc1sc2c(c1-c1ccccc1)C(=O)CC2,,ClCCl,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US05563141,CCOC(=O)N1CCN(C(=CN(C)C)C(=O)OC)CC1.COc1cccc(N)c1>>CCOC(=O)N1CCN(C(=CNc2cccc(OC)c2)C(=O)OC)CC1,,CCO,,Cl,,val
US20120015908A1,CC(=O)c1cc2c(cc1NC(=O)c1coc3ccccc13)OCO2>>O=C1CC(c2coc3ccccc23)=Nc2cc3c(cc21)OCO3,,C1COCCO1,,[Na+].[OH-],,val
US20140024679A1,CCOCCCC(=O)OCC>>CCOCCCC(=O)O,,C1CCOC1,,[Na+].[OH-],,val
US20130165464A1,COC(=O)Cl.NC(=O)c1cn(-c2cc(N)ncc2Cl)cc1-c1ccccc1Cl>>COC(=O)Nc1cc(-n2cc(C(N)=O)c(-c3ccccc3Cl)c2)c(Cl)cn1,,ClCCl,,,,val
US05556990,Brc1ccc(-c2ccc3ccccc3c2)cc1.O=C1CCCN(Cc2ccccc2)C1>>OC1(c2ccc(-c3ccc4ccccc4c3)cc2)CCCN(Cc2ccccc2)C1,,C1CCOC1,,[Li]CCCC,,val
US20080114016A1,O=[N+]([O-])c1ccc(CO)c(CCO)c1>>O=[N+]([O-])c1ccc2c(c1)CCOC2,,Cl,,,,val
US03947582,CC(O)(C(N)=O)c1ccc(C(=O)O)cc1>>C=C(C(N)=O)c1ccc(C(=O)O)cc1,,CC(=O)O,,O=S(=O)(O)O,,val
US20120309757A1,C=C(C)c1cccc([C@H](C)NC(=O)c2ccc3c(c2)c(C)c(C)n3Cc2ccc(-c3ccccc3C(=O)OC(C)(C)C)cc2)c1>>Cc1c(C)n(Cc2ccc(-c3ccccc3C(=O)OC(C)(C)C)cc2)c2ccc(C(=O)N[C@@H](C)c3cccc(C(C)C)c3)cc12,[Pd],CCO,,,,val
US20070112068A1,CCCI.N#CC(C#N)CC(F)(F)C(F)(F)C(F)(F)C(F)F>>CCCC(C#N)(C#N)CC(F)(F)C(F)(F)C(F)(F)C(F)F,,COCCOC,,Cl,O=C([O-])[O-].[K+].[K+],val
US04405357,CC(C)(C)C(=O)Cl.ONCc1ccccc1Cl>>CC(C)(C)C(=O)N(O)Cc1ccccc1Cl,,ClCCl,,c1ccncc1,,val
US20150299219A1,NC(=O)c1nccc(Cl)c1Cl.O=C(Nc1ccc(O)cn1)c1c2n(n(-c3ccccc3)c1=O)CCCC2>>NC(=O)c1nccc(Oc2ccc(NC(=O)c3c4n(n(-c5ccccc5)c3=O)CCCC4)nc2)c1Cl,,CN(C)C=O,O,CC(C)(C)[O-].[K+],,val
US20090227570A1,O=C(Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1)NC1CCNCC1.OCCBr>>O=C(Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1)NC1CCN(CCO)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20110070317A1,CC(C)(C)OC(=O)N[C@@H]1CCCNC1.ClCCl.Cn1cc(C(=O)Nc2c[nH]c3ncc(Br)c(F)c23)ccc1=O>>Cl.Cn1cc(C(=O)Nc2c[nH]c3ncc(Br)c(N4CCC[C@@H](N)C4)c23)ccc1=O,,CCCCO,,O=C(O)C(F)(F)F,,val
US20150266857A1,C=CC(=O)OCC.O=S(=O)(c1ccccc1)n1cc(-c2ccc3[nH]ncc3c2)c2ccc(F)cc21>>CCOC(=O)CCn1ncc2cc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)ccc21,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20090042852A1,CCc1cnc(-c2cnc(N3CCC(C(=O)OC)CC3)c(Cl)c2S(C)=O)o1>>CCc1cnc(-c2cnc(N3CCC(C(=O)O)CC3)c(Cl)c2S(C)=O)o1,,C1CCOC1,,[Li+].[OH-],,val
US20100168171A1,CC(=O)CCCC(=O)O.CN.[C-]#[N+]Cc1ccc(Cl)cc1Cl>>CN1C(=O)CCCC1(C)C(=O)NCc1ccc(Cl)cc1Cl,,CO,,CCO,,val
US06107338,CO.O=C(O)C=Cc1ccccc1F>>COC(=O)CCc1ccccc1F,[Pd],,,CCOC(C)=O,[H][H],val
US20080200454A1,COC(=O)[C@H]1Cc2ccc(C#Cc3cc(-c4nn(CCCN5CCOCC5)c5c4CN(S(C)(=O)=O)CC5)ccc3Cl)cc2CN1>>CS(=O)(=O)N1CCc2c(c(-c3ccc(Cl)c(C#Cc4ccc5c(c4)CN[C@@H](CO)C5)c3)nn2CCCN2CCOCC2)C1,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US05036078,CS(=O)(=O)Cl.NCCc1ccc2[nH]ccc2c1>>CS(=O)(=O)NCCc1ccc2[nH]ccc2c1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20060223829A1,CCOC(=O)C1(N2CCNCC2)CCC1.O=S(=O)(Cl)c1ccccc1Cl>>CCOC(=O)C1(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)CC1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20150038528A1,CC(C)(C)OC(=O)C(CN)C1CC1.COC(=O)c1ncc2cc(Oc3ccccc3)ccc2c1O>>CC(C)(C)OC(=O)C(CNC(=O)c1ncc2cc(Oc3ccccc3)ccc2c1O)C1CC1,,CC(=O)N(C)C,,C1CCC2=NCCCN2CC1,,val
US20120035226A1,CCc1ccccc1-c1ccc(C(=O)OC)cc1C(F)(F)F>>CCc1ccccc1-c1ccc(C(=O)O)cc1C(F)(F)F,,CCO,,[Na+].[OH-],,val
US20100056506A1,COC(=O)c1ccc(C)c(OC)c1[N+](=O)[O-]>>COC(=O)c1ccc(C)c(OC)c1N,[Pd],CCO,,[H][H],,val
US20070244095A1,Cc1cc2c(cc1C(F)(F)F)N(C(=O)OC(C)C)CCCC2N(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cccnc1>>Cc1cc2c(cc1C(F)(F)F)N(C(=O)OC(C)C)CCCC2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cccnc1,,C1CCOC1,,,,val
US04284631,Cc1nc(CON=C(C(=O)NC2C(=O)N3C(C(=O)O)=CCS[C@H]23)c2csc(NC=O)n2)cs1.Cl>>Cc1nc(CON=C(C(=O)NC2C(=O)N3C(C(=O)O)=CCS[C@H]23)c2csc(N)n2)cs1.Cl,,CO,,,,val
US05985849,CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cc(C3(O)c4ccccc4-c4ccccc43)c(=O)[nH]c2=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C>>O=c1[nH]c(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1C1(O)c2ccccc2-c2ccccc21,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20030224293A1,O=S(=O)(Cl)c1ccccc1.OCCOc1ccccc1>>O=S(=O)(OCCOc1ccccc1)c1ccccc1,,CCN(CC)CC,,Cc1ccccc1,,val
US20160143895A1,CCn1c(C(=O)O)cc2c(F)cccc21.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c([C@H]3CCCNC3)cc12>>CCn1c(C(=O)N2CCC[C@H](c3cc4c(C(=O)NC)c(-c5ccc(F)cc5)oc4cc3N(C)S(C)(=O)=O)C2)cc2c(F)cccc21,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,CCN=C=NCCCN(C)C,val
US20020187978A1,Cc1c(C(=O)NCc2ccccc2)c[nH]c1C=O.O=C1Cc2c(cccc2C2CCNCC2)N1>>Cc1c(C(=O)NCc2ccccc2)c[nH]c1C=C1C(=O)Nc2cccc(C3CCNCC3)c21,C1CCNCC1,CCO,,,,val
US20050090533A1,CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(Cl)cc1-c1ccccc1Cl.NCCO>>CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(NCCO)cc1-c1ccccc1Cl,,CCOC(C)=O,,CS(C)=O,,val
US06498165B1,CO.C[Si](C)(C)C=[N+]=[N-].O=C(O)c1cc2nc[nH]c2cc1C(=O)O>>COC(=O)c1cc2nc[nH]c2cc1C(=O)OC,,CCOC(C)=O,,CCOCC,O,val
US20030199440A1,CC(C)[C@@H](N)C(=O)OC(C)(C)C.O=S(=O)(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>CC(C)[C@@H](NS(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1)C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20110201629A1,CNc1cccnc1[N+](=O)[O-]>>CNc1cccnc1N,[Pd],CO,,,,val
US20150045332A1,O=C(O)c1cc(Cl)nc(Cl)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=NC(=O)c1cc(Cl)nc(Cl)c1,,CCOC(C)=O,,CCN(CC)CC,,val
US20100035863A1,CNC1CCCCC1.Nc1nc(Cl)cc(Cl)n1>>CN(c1cc(Cl)nc(N)n1)C1CCCCC1,,CCO,,CCN(CC)CC,,val
US20150344466A1,C[Si](C)(C)C#Cc1c(C(=O)NCC2CCOC2)noc1COCc1ccc2ccccc2c1>>C#Cc1c(C(=O)NCC2CCOC2)noc1COCc1ccc2ccccc2c1,,CO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100305096A1,CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1.O[C@H]1CCN(C2CNC2)C1>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CC(N4CC[C@H](O)C4)C3)n(C)c2n1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090111809A1,CC(C)(C)OC(=O)c1ccc(-c2cc(Cl)c(C[C@@H]3CCN(N4CCOCC4)C3=O)c(Cl)c2)cc1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C(O)c1ccc(-c2cc(Cl)c(C[C@@H]3CCN(N4CCOCC4)C3=O)c(Cl)c2)cc1,,ClCCl,,,,val
US20020094989A1,CC(C)(C)OC(=O)N1CCC(C(=O)CC(=O)Cc2ccccc2)CC1.CCNN>>CCn1nc(C2CCN(C(=O)OC(C)(C)C)CC2)cc1Cc1ccccc1,,CO,,O=C(O)C(=O)O,,val
US20020143182A1,COc1ccc(-c2ccc3cc(C4SC(=O)NC4=O)ccc3c2)cc1C12CC3CC(CC(C3)C1)C2>>O=C1NC(=O)C(c2ccc3cc(-c4ccc(O)c(C56CC7CC(CC(C7)C5)C6)c4)ccc3c2)S1,,ClCCl,,,,val
US20160102071A1,CC#C[C@@H](CC(=O)OCC)c1ccc(OCc2ccc3scc(-c4cc(Cl)ncc4C)c3c2)nc1>>CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3scc(-c4cc(Cl)ncc4C)c3c2)nc1,,CCO,,Cl,[Li+].[OH-],val
US20110212102A1,CC(C)(C)OC(=O)N1CCC[C@@H](Oc2cc(F)ccc2[N+](=O)[O-])C1>>CC(C)(C)OC(=O)N1CCC[C@@H](Oc2cc(F)ccc2N)C1,[Pd],CO,,O=C[O-].[NH4+],,val
US20110312969A1,N=c1n(CCCOc2ccc(F)cc2)c2ccccc2n1Cc1csc(Cl)n1.c1ccc(-c2ccccc2CN2CCNCC2)cc1>>N=c1n(CCCOc2ccc(F)cc2)c2ccccc2n1Cc1csc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)n1,[Cu]I,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20010001101A1,CCOC=C(C(=O)OCC)C(=O)OCC.Nc1cccc2cccnc12>>CCOC(=O)C1C=Nc2c(ccc3cccnc23)C1=O,,CCCCCC,CCO,c1ccc(Oc2ccccc2)cc1,,val
US04876271,O=Cc1cc2sccc2s1.OCCO>>c1cc2sc(C3OCCO3)cc2s1,,c1ccccc1,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20030191129A1,COc1ccc(N)cc1.Cc1c(Cl)nnc(Cc2ccncc2)c1C>>COc1ccc(Nc2nnc(Cc3ccncc3)c(C)c2C)cc1,,CO,ClCCl,,,val
US20070244092A1,CC(C)(C)c1nc2cc(S(=O)(=O)N3CC(N)C3)ccc2n1CC1CCC(F)(F)CC1.CCC(=O)OC(=O)CC>>CCC(=O)NC1CN(S(=O)(=O)c2ccc3c(c2)nc(C(C)(C)C)n3CC2CCC(F)(F)CC2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090247577A1,CN(C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1Cc1ccccc1)C(=O)C1CC(=O)Nc2ccccc21>>CN(C[C@@H]1CNC[C@H]1Cc1ccccc1)C(=O)C1CC(=O)Nc2ccccc21,,C1COCCO1,Cl,,,val
US20130196974A1,Cc1ccc2nc(N3CCSc4ccccc4C3)nc(NCCNC(=O)OC(C)(C)C)c2c1>>Cc1ccc2nc(N3CCSc4ccccc4C3)nc(NCCN)c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090054451A1,CI.N#Cc1ccc(CC(=O)NC2CCN(CCC(c3ccccc3)c3ccccc3)CC2)cc1>>C[N+]1(CCC(c2ccccc2)c2ccccc2)CCC(NC(=O)Cc2ccc(C#N)cc2)CC1.[I-],,ClCCl,,,,val
US04223032,CCOC(=O)c1nnn(-c2ccccc2)c1N>>CCOC(=O)c1[nH]nnc1Nc1ccccc1,,CCO,,[Na],,val
US20100022484A1,CC(=O)C(=Cc1cccc2c(=O)cc(C)oc12)C(=O)c1ccccc1.CCCOC(=O)/C=C(/C)N>>CCCOC(=O)C1=C(C)NC(C)=C(C(=O)c2ccccc2)C1c1cccc2c(=O)cc(C)oc12,,CCO,,,,val
US20050075499A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(O)[C@@H]1NCC[C@@H]1c1ccccc1>>CC(C)(C)OC(=O)N1CCC(C(=O)O)C1c1ccccc1,,C1COCCO1,O,CCN(CC)CC,,val
US20120165318A1,CCCCOC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCC[C@@H]3C)nc2c1>>C[C@H]1CCCN1c1nc2cc(C(=O)O)ccc2nc1-c1ccc(F)cc1,,O,,CO,[Na+].[OH-],val
US04147672,CC1=C(CO)C=CCC1(C)C>>CC1C(CO)=CCCC1(C)C,[Ni],CCO,,,,val
US20060106069A1,COC(=O)c1cc(-c2cc(NC(C)C)ncc2Cl)cn1S(=O)(=O)c1c(C)cc(C)cc1C>>CC(C)Nc1cc(-c2c[nH]c(C(=O)O)c2)c(Cl)cn1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US05455237,Fc1cccc(F)c1C(Cl)=NN=C(Cl)c1c(F)cccc1F.NN>>Fc1cccc(F)c1-c1nnc(-c2c(F)cccc2F)nn1,,C1CCOC1,,O,,val
US20140080798A1,COC(=O)Cc1ccccc1C#Cc1nc(Nc2ccc(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)cc2)ncc1C(F)(F)F>>COC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)cc2)ncc1C(F)(F)F,[Pd],CCN(CC)CC,,,,val
US20150376130A1,CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.COc1cccc(CNc2ncccc2C(=O)O)c1>>C#CC(C)(C)NC(=O)c1cccnc1NCc1cccc(OC)c1,,ClCCl,,On1nnc2ccccc21,,val
US20140371278A1,C=COCCONC(=O)c1cc2snnc2c(F)c1Nc1ccc(I)cc1F>>O=C(NOCCO)c1cc2snnc2c(F)c1Nc1ccc(I)cc1F,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US20160159752A1,Fc1ccc([Mg]Br)cc1.O=C(/C=C/C1CCOCC1)N1C(=O)OC[C@H]1c1ccccc1>>O=C(C[C@@H](c1ccc(F)cc1)C1CCOCC1)N1C(=O)OC[C@H]1c1ccccc1,,C1CCOC1,,CSC,,val
US20130143862A1,C=CB1OB(C=C)OB(C=C)O1.CC(C)(CNc1ccc(Cl)nn1)c1ccc(F)cc1>>C=Cc1ccc(NCC(C)(C)c2ccc(F)cc2)nn1,,CCOC(C)=O,O,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20090137609A1,CCC(CC)(c1ccc(CCC(O)C(C)(C)C)c(C)c1)c1ccc(-c2cccc([C@@H](O)C(=O)OC)c2)c(C)c1>>CCC(CC)(c1ccc(CCC(O)C(C)(C)C)c(C)c1)c1ccc(-c2cccc([C@@H](O)C(=O)O)c2)c(C)c1,,CO,,Cl,[Na+].[OH-],val
US05236559,C=COC(C)=O.CCCCCC.COCCOCCO>>C=CC(=O)OC.C=COC(C)=O,,CCCCCC,,,,val
US06166006,COC(=O)C1CCSc2ccc(Br)cc2C1=O>>COC(=O)C1=Cc2cc(Br)ccc2SCC1,,C1CCOC1,CO,O,[BH4-].[Na+],val
US20100113796A1,FC(F)(F)c1sc(-c2nc(-c3ccc4[nH]ccc4c3)no2)cc1-c1ccccc1.O=C1CCC(=O)N1Cl>>FC(F)(F)c1sc(-c2nc(-c3ccc4[nH]cc(Cl)c4c3)no2)cc1-c1ccccc1,,ClCCl,,,,val
US20040157886A1,O=C(O)C(=O)Nc1ccc2[nH]c(=O)sc2c1.c1ccc(CC2CCNCC2)cc1>>O=C(Nc1ccc2[nH]c(=O)sc2c1)C(=O)N1CCC(Cc2ccccc2)CC1,,CCOCC,,,,val
US20100010035A1,CCc1cc2[nH]c(=O)cc(Cl)c2c(CC)n1.COCCOCN(c1noc(C)c1C)S(=O)(=O)c1sc(C)cc1-c1ccc(COS(C)(=O)=O)cc1C>>CCc1cc2c(c(Cl)cc(=O)n2Cc2ccc(-c3cc(C)sc3S(=O)(=O)N(COCCOC)c3noc(C)c3C)c(C)c2)c(CC)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140031558A1,CC(C)O.O=C(F)c1nc(F)c(F)c(F)c1F>>CC(C)OC(=O)c1nc(F)c(F)c(F)c1F,,O,,CCN(CC)CC,,val
US06277850B1,CCOC(=O)c1ccc(N=C=O)cc1.COC1CC(CN)C(OC)O1>>CCOC(=O)c1ccc(NC(=O)NCC2CC(OC)OC2OC)cc1,,C1CCOC1,,,,val
US20120149691A1,COC(=O)c1cc([N+](=O)[O-])c[nH]1.NOP(=O)(c1ccccc1)c1ccccc1>>COC(=O)c1cc([N+](=O)[O-])cn1N,,CCOC(C)=O,CN(C)C=O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20150210697A1,N#Cc1cc(NC(=O)CBr)c(Cl)c([N+](=O)[O-])c1.NCCO>>N#Cc1cc(NC(=O)CNCCO)c(Cl)c([N+](=O)[O-])c1,,C1CCOC1,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130131016A1,CC1(C)OB(O)c2ccc(C=O)cc21.NO>>CC1(C)OB(O)c2ccc(C=NO)cc21,,C1CCOC1,O,Cl,CC(=O)[O-].[Na+],val
US04230712,Brc1ccccc1.COC1=C[C@]23CCN(C)[C@H](Cc4ccc(OC)c(O)c42)C3=C[C@H]1C>>COC1=C[C@]23CCN(C)[C@H](Cc4ccc(OC)c(Oc5ccccc5)c42)C3=C[C@H]1C,[Cu],c1ccncc1,,O=C([O-])[O-].[K+].[K+],,val
US20150232464A1,Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)O.ClCCl.O=C(Cl)C(=O)Cl>>Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)Cl.Cl,,ClCCl,,CN(C)C=O,,val
US20080242644A1,CO.COc1c(Br)cc(C(C)(C)C(=O)[O-])cc1C=O.COc1ccc(S(=O)(=O)NC(C)(C)C)cc1B(O)O>>COC(=O)C(C)(C)c1cc(C=O)c(OC)c(-c2cc(S(=O)(=O)NC(C)(C)C)ccc2OC)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20090124802A1,Cc1cc(C)c(Oc2nc(Nc3ccc(C#N)cc3)nc3c2ccn3Cc2ccccc2)c(C)c1>>Cc1cc(C)c(Oc2nc(Nc3ccc(C#N)cc3)nc3[nH]ccc23)c(C)c1,,Clc1ccccc1Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20090069326A1,CC(C)[Si](O[C@@H]1CC[C@@H](N2CC[C@@H](Cc3c(Cl)cc(OS(=O)(=O)C(F)(F)F)cc3Cl)C2=O)CC1)(C(C)C)C(C)C.COC(=O)c1ccc(B(O)O)cc1>>COC(=O)c1ccc(-c2cc(Cl)c(C[C@@H]3CCN([C@@H]4CC[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)CC4)C3=O)c(Cl)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20090291937A1,CCC(C)(CNC(=O)OC(C)(C)C)c1cccc(B2OC(C)(C)C(C)(C)O2)c1.Cc1n[nH]c2nccc(I)c12>>CCC(C)(CNC(=O)OC(C)(C)C)c1cccc(-c2ccnc3[nH]nc(C)c23)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20040220191A1,CCOC(=O)C1CCC(O)CC1.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>O=C(O)C1CCC(Oc2ccccc2)CC1,,c1ccncc1,,,,val
US20020128247A1,Cc1ccc(S(=O)(=O)Cl)cc1.OC[C@H](O)c1ccc(Cl)nc1>>Cc1ccc(S(=O)(=O)OC[C@H](O)c2ccc(Cl)nc2)cc1,,c1ccncc1,,,,val
US20120196864A1,CCN(CC)CCN.COc1cc(/C=C2\NC(=O)N=C2N)ccc1Oc1ccc(C#N)cc1C(F)(F)F>>CCN(CC)CCNC1=NC(=O)N/C1=C\c1ccc(Oc2ccc(C#N)cc2C(F)(F)F)c(OC)c1,,CO,,,,val
US05438139,Cc1ccccc1O.O=[N+]([O-])O>>Cc1cccc([N+](=O)[O-])c1O,,CC(=O)O,,,,val
US20140275058A1,Fc1ccc(Br)cc1C1=NOC(CCl)C1>>Fc1ccc(Br)cc1C1=NOC2CC12,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20060148862A1,CN(Cc1cc(-c2ccc(C=O)cc2)cs1)C(=O)c1ccccc1.O=C1CSC(=O)N1>>CN(Cc1cc(-c2ccc(C=C3SC(=O)NC3=O)cc2)cs1)C(=O)c1ccccc1,,Cc1ccccc1,,C1CC[NH2+]CC1.CC(=O)[O-],,val
US09150556B2,CCOC(=O)CCn1c(=O)n(Cc2c(C(=O)OC)ccc3c(C)c(C)n(C)c23)c2ccccc21>>COC(=O)c1ccc2c(C)c(C)n(C)c2c1Cn1c(=O)n(CCC(=O)O)c2ccccc21,,C1COCCO1,O,[Li+].[OH-],,val
US20110039855A1,COc1c(F)cccc1CO.CS(=O)(=O)Cl>>COc1c(F)cccc1CCl,,CCOCC,ClCCl,CCN(CC)CC,,val
US20150291563A1,CC(C)(C)OC(=O)N1CC=C(c2cccc(N3N=C(C(O)(C(F)(F)F)C(F)(F)F)CC3c3ccccc3Cl)c2)CC1.Cl>>Cl.OC(C1=NN(c2cccc(C3=CCNCC3)c2)C(c2ccccc2Cl)C1)(C(F)(F)F)C(F)(F)F,,CCOC(C)=O,,,,val
US20150315145A1,CCOC(=O)[C@@H]1CC[C@@H](NOCc2ccccc2)CN1.N>>NC(=O)[C@@H]1CC[C@@H](NOCc2ccccc2)CN1,,CO,,,,val
US20040097485A1,CC(C)(C)c1ccc(-c2cc3c(Cl)ncc(C#N)c3s2)cc1.NC1CCCCC1>>CC(C)(C)c1ccc(-c2cc3c(NC4CCCCC4)ncc(C#N)c3s2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05508272,CCCC[C@@H](N)C(=O)O.[Br-]>>CCCC[C@H](Br)C(=O)O,,O=S(=O)(O)O,,O=N[O-].[Na+],,val
US05114939,CC(C)(C)c1ccc(CCO)cc1.Fc1cccc2c(Cl)ccnc12>>CC(C)(C)c1ccc(CCOc2ccnc3c(F)cccc23)cc1,,CN(C)C=O,,[H-].[Na+],,val
US04307038,C=CC(=O)O.NC(P(=O)(O)O)P(=O)(O)O>>O=C(O)CCNC(P(=O)(O)O)P(=O)(O)O,,O,,Cl,[Na+].[OH-],val
US20130225602A1,Brc1cn(C2CC2)c2nc(OCc3ccccn3)ccc12.CCOC(=O)N1CCNC(=O)C1>>CCOC(=O)N1CCN(c2cn(C3CC3)c3nc(OCc4ccccn4)ccc23)C(=O)C1,[Cu]I,CN(C)C=O,,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20080306060A1,CC1(C)CC(=O)c2sc(N3CCOCC3)nc2C1.NOS(=O)(=O)O>>CC1(C)CC(=O)Nc2sc(N3CCOCC3)nc2C1,,O=CO,,,,val
US20040009995A1,COC(=O)c1cc(Sc2ccccc2OC)c([N+](=O)[O-])s1>>COC(=O)c1cc(Sc2ccccc2OC)c(N)s1,,C1CCOC1,,,,val
US20080004257A1,C[Mg]Br.O=Cc1cc(Br)ccc1F>>CC(O)c1cc(Br)ccc1F,,CCOCC,,,,val
US20040127493A1,Cc1ccc(S(=O)(=O)OCC2COc3cccc(N)c3N2)cc1.O=C(n1ccnc1)n1ccnc1>>Cc1ccc(S(=O)(=O)OCC2COc3cccc4[nH]c(=O)n2c34)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20050014749A1,Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(/C=C/C#N)ccc32)cc1>>Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CCCN)ccc32)cc1,O=[Pt]=O,CCO,,ClC(Cl)Cl,,val
US04124726,CCCCc1ccccc1.O=C(Cl)c1ccccc1F>>CCCCc1ccc(C(=O)c2ccccc2F)cc1,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04247548,O=S(=O)(Cl)c1ccccc1.Oc1cc(CCC(=S)OC(c2ccccc2)c2ccccc2)on1>>O=S(=O)(Oc1cc(CCC(=S)OC(c2ccccc2)c2ccccc2)on1)c1ccccc1,,CCN(CC)CC,,,,val
US20010053853A1,C#CCCC(=O)O.CCCCO>>C#CCCC(=O)OCCCC,,CCCCO,,Cl,,val
US20160096827A1,C1NCC2COCC12.O=[N+]([O-])c1ccc(F)cc1>>O=[N+]([O-])c1ccc(N2CC3COCC3C2)cc1,,CCOC(C)=O,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],,val
US05039701,COc1c(C(C)=O)c(O)c(OC)c2occc12>>COc1c(O)c(C(C)=O)c(OC)c2c1OCC2,[Pd],CO,,,,val
US20140018533A1,C1CCNCC1.CCO.Cc1cc(NCCN2CCCC2)ccc1NC1=C(C(=O)[O-])C(=O)CO1.O=Cc1c[nH]c2ncccc12>>CC(=O)O.CCOC(=O)C1=C(Nc2ccc(NCCN3CCCC3)cc2C)OC(=Cc2c[nH]c3ncccc23)C1=O,,CCO,,,,val
US20060241302A1,CC(C)(C)OC(=O)N1CCC(Nc2cc(C(c3cc(F)ccc3F)S(=O)(=O)c3ccc(Cl)cc3)c(Cl)cn2)CC1.Cl.ClC(Cl)Cl>>Cl.Cl.O=S(=O)(c1ccc(Cl)cc1)C(c1cc(F)ccc1F)c1cc(NC2CCNCC2)ncc1Cl,,ClC(Cl)Cl,,CO,,val
US04066772,ClCCCCn1cnc2ccccc21.O=c1[nH]c2ccccc2n1C1CCNCC1>>O=c1[nH]c2ccccc2n1C1CCN(CCCCn2cnc3ccccc32)CC1,,CC(=O)CC(C)C,O,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20100239526A1,CN(C)/C=C1/CCc2c(cnn2-c2ccccc2)C1=O.COc1ccc(Cn2nccc2N)cc1>>COc1ccc(Cn2ncc3c4c(cnc32)CCc2c-4cnn2-c2ccccc2)cc1,,O,,O=C(O)C(F)(F)F,,val
US20120108583A1,COC(=O)c1cc2nc(Nc3c(F)cccc3Cl)n(C)c2c2c1OC(C)(C)C2>>Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)O)c3c(c21)CC(C)(C)O3,,CO,,[Na+].[OH-],,val
US20070287724A1,O=C(OO)c1cccc(Cl)c1.OC1(Cn2c(CCl)nc3cnc4ccccc4c32)CCC1>>[O-][n+]1cc2nc(CCl)n(CC3(O)CCC3)c2c2ccccc21,,ClC(Cl)Cl,,,,val
US05106842,CC(C)(C)OC(=O)CN1C(=O)[C@@H](N)[C@H]1CCc1ccco1.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)CN1C(=O)[C@@H](NC(=O)OCc2ccccc2)[C@H]1CCc1ccco1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020143009A1,CC(C)(C)C1Cc2cc(N3C[C@H](CN)OC3=O)ccc2N1C=O.CCSC(C)=S>>CC(=S)NC[C@H]1CN(c2ccc3c(c2)CC(C(C)(C)C)N3C=O)C(=O)O1,,CO,,CCN(CC)CC,Cl,val
US20020173507A1,CCCN.O=C1CCN(Cc2cccc(NC(=O)Nc3csc(-c4ccncc4)n3)n2)CC1>>CCCNC1CCN(Cc2cccc(NC(=O)Nc3csc(-c4ccncc4)n3)n2)CC1,,CO,,[BH4-].[Na+],,val
US20110085985A1,CN(C)C=O.ClCCl.Nc1ccc(F)nc1F.c1ccncc1>>CNc1ccc(-c2nc3ccc(F)nc3o2)cc1,,ClCCl,c1ccncc1,O=C([O-])[O-].[K+].[K+],,val
US20150158815A1,COc1cccc(C(Nc2cncc(Br)c2)C(N)=O)c1.OB(O)c1cc(Cl)ccc1F>>COc1cccc(C(Nc2cncc(-c3cc(Cl)ccc3F)c2)C(N)=O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20150336949A1,Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4cccc(N5CCN(C(=O)OC(C)(C)C)CC5)c4)cnc32)cc1.Cl>>Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4cccc(N5CCNCC5)c4)cnc32)cc1.Cl,,C1COCCO1,,CO,,val
US20030232869A1,Cc1cc(C#C[Si](C)(C)C)ccc1Nc1c(C(=O)NOCC2CC2)cc2[nH]cnc2c1F>>C#Cc1ccc(Nc2c(C(=O)NOCC3CC3)cc3[nH]cnc3c2F)c(C)c1,O,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20030018034A1,COC(=O)C(C)(C)c1ccc(CNC(C)=O)cc1>>CC(=O)NCc1ccc(C(C)(C)C(=O)O)cc1,,CCO,O,[Na+].[OH-],,val
US20100273744A1,O=C(O)c1ccc(O)cc1C(F)(F)F>>OCc1ccc(O)cc1C(F)(F)F,,C1CCOC1,,CO,,val
US20100273764A1,CC(Br)c1ccc(F)nc1.C[C@H]1CN(C(=O)OC(C)(C)C)CCN1>>C[C@H]1CN(C(=O)OC(C)(C)C)CCN1[C@H](C)c1ccc(F)nc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110245296A1,N#C[Cu].Oc1nccc(C(F)(F)F)c1Oc1cc(Cl)cc(Br)c1>>N#Cc1cc(Cl)cc(Oc2c(C(F)(F)F)ccnc2O)c1,,CN1CCCC1=O,,CC(=O)O,,val
US08263620B2,Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(=O)OC(C)(C)C)C2CC(=O)O.O=C(O)C(F)(F)F>>Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCNC2CC(=O)O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20160229814A1,CCn1c(=O)c2nc(Br)ccc2n(CC)c1=O.N>>CCn1c(=O)c2nc(N)ccc2n(CC)c1=O,O=[Cu],CN1CCCC1=O,,,,val
US20090264499A1,CC(C)(C)OC(=O)N1CC[C@@H](N)C1.COc1ccc([N+](=O)[O-])cc1S(=O)(=O)Cl>>COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N[C@@H]1CCN(C(=O)OC(C)(C)C)C1,,ClCCl,,c1ccncc1,,val
US04616025,N#CN=C1NCCS1.O=[N+]([O-])c1ccc(O)c(CCl)c1>>N#CN=C1SCCN1Cc1cc([N+](=O)[O-])ccc1O,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US06080738,CCNC(=O)c1ccc2oc(C(O)C(Cc3ccccc3)NC(=O)Cn3c(-c4ccc(F)cc4)ncc(NC(=O)OCc4ccccc4)c3=O)nc2c1>>CCNC(=O)c1ccc2oc(C(=O)C(Cc3ccccc3)NC(=O)Cn3c(-c4ccc(F)cc4)ncc(NC(=O)OCc4ccccc4)c3=O)nc2c1,,CS(C)=O,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20070244130A1,COC(=O)COc1ccc(O)cc1C.FC(F)(F)Oc1ccc(-c2oc(CBr)nc2Br)cc1>>COC(=O)COc1ccc(OCc2nc(Br)c(-c3ccc(OC(F)(F)F)cc3)o2)cc1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070027163A1,CI.CN(C)C=O.NS(=O)(=O)CCCn1cc(C(=O)N2CCN(c3ccccc3F)CC2)c2ccc(Cl)cc21>>CC(=O)N(C)CCn1cc(C(=O)N2CCN(c3ccccc3F)CC2)c2ccc(Cl)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20080021026A1,CC(=O)CBr.Sc1ccc(Br)cc1>>CC(=O)CSc1ccc(Br)cc1,,CCOCC,,c1ccncc1,,val
US20130109677A1,C1CO1.CCc1cccs1>>CCc1ccc(CCO)s1,,CCOCC,CCOCC,[Li]CCCC,,val
US20070287712A1,CC(C)(C)OC(=O)N1CCN(C(=CC#N)c2ccccc2)CC1>>N#CC=C(c1ccccc1)N1CCNCC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100273764A1,COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(OCc4ccccc4)cnc3F)n2)cc1>>COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(O)cnc3F)n2)cc1,[Pd],CCOC(C)=O,,,,val
US20120264735A1,CCN(CC)S(F)(F)F.CCOC(=O)Nc1cccc(C(O)c2nn(-c3cnn(C)c3)ccc2=O)c1>>CCOC(=O)Nc1cccc(C(F)c2nn(-c3cnn(C)c3)ccc2=O)c1,,ClCCl,,CO,,val
US04411899,CCOC(=O)CS(=O)(=O)Cl.C[Si](C)(C)N[Si](C)(C)C>>CCOC(=O)CS(N)(=O)=O,,ClCCl,,,,val
US06432981B1,C1CCOC1.O.O=C(CCCc1ccccc1)C1CCN(Cc2ccccc2)CC1>>O=CC(CCc1ccccc1)C(=O)C1CCN(Cc2ccccc2)CC1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20110034440A1,C=NN1CCCCCC1.Cl>>CNN1CCCCCC1.Cl,,CCOCC,,C1COCCO1,,val
US04281019,C=CCNc1ccc(C#N)cc1.CO>>C=CCNc1ccc(C=O)cc1,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20110124858A1,CCC(=O)NC1CCc2cc(C#N)ccc21.O=CO>>CCC(=O)NC1CCc2cc(C=O)ccc21,[Ni],,,,,val
US20120083488A1,CC(C)(O)C#Cc1cc2c(cc1OC[C@H]1COC(C)(C)O1)C(C)(C)c1[nH]c3cc(Cl)ccc3c1C2=O>>CC(C)(O)C#Cc1cc2c(cc1OC[C@H](O)CO)C(C)(C)c1[nH]c3cc(Cl)ccc3c1C2=O,,CO,,Cl,,val
US05547975,C=CC(=O)O.Sc1cccc(Cl)c1>>O=C(O)CCSc1cccc(Cl)c1,,CCOCC,,,,val
US20120258946A1,O=C(NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1)Nc1ccc(CO)c(F)c1>>O=Cc1ccc(NC(=O)NCc2cc(C(F)(F)F)nn2-c2cccc(Cl)c2)cc1F,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20060229337A1,CCOC(=O)c1ccc(Nc2nc(-c3cccc(NC(=O)c4ccc(C(C)(C)C)cc4)c3C)cn(C)c2=O)cc1>>Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(C(=O)O)cc2)n1,,CCO,,[Na+].[OH-],,val
US06458780B1,CC(=O)c1ncn2cc(C3=C(C(=O)[O-])N4C(=O)[C@H]([C@@H](C)O)[C@H]4[C@H]3C)sc12.CCOC(=O)OC(C)I>>CCOC(=O)OC(C)OC(=O)C1=C(c2cn3cnc(C(C)=O)c3s2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12,,CN(C)C=O,,CCOC(C)=O,,val
US20090137609A1,CC(C)(C)C(=O)CCl.CCC(CC)(c1ccc(O)c(C)c1)c1ccc(OS(=O)(=O)C(F)(F)F)c(C)c1>>CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1ccc(OS(=O)(=O)C(F)(F)F)c(C)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140364396A1,CC(C)(C)OC(=O)Cn1ccc2ccccc2c1=O>>O=C(O)Cn1ccc2ccccc2c1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US05187168,COC(=O)c1ccccc1-c1ccc(CN)cc1.Clc1nc(Cl)c2sccc2n1>>COC(=O)c1ccccc1-c1ccc(CNc2nc(Cl)nc3ccsc23)cc1,,C1CCOC1,C1CCOC1,Cl,CC(=O)[O-].[Na+],val
US20120225867A1,CC(=O)c1nc(C(=O)NC[C@H](C)n2ccc(-c3ccc(C#N)c(Cl)c3C)n2)co1>>Cc1c(-c2ccn([C@@H](C)CNC(=O)c3coc(C(C)O)n3)n2)ccc(C#N)c1Cl,,CCO,,[BH4-].[Na+],,val
US20140023691A1,CCCCCC(C(=O)CCCCCc1ccccc1)[N+](=O)[O-].N#CN>>CCCCCc1[nH]c(N)nc1CCCCCc1ccccc1,[Pd],,,Cl,,val
US20080139558A1,COS(=O)(=O)OC.Cc1ncsc1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(Cl)c1>>Cc1ncsc1C(=O)N(Cc1cc(=O)n(C)c2c(F)cccc12)c1cccc(Cl)c1,,ClCCl,,[H-].[Na+],,val
US20110152296A1,O=[N+]([O-])c1cc(F)cnc1C1OCCO1>>Nc1cc(F)cnc1C1OCCO1,[Pd],CCO,,,,val
US20150266874A1,CCOC(=O)c1cn(COCC[Si](C)(C)C)nc1I.Cc1ccc2sc(B(O)O)cc2c1>>CCOC(=O)c1cn(COCC[Si](C)(C)C)nc1-c1cc2cc(C)ccc2s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20070066618A1,O=C(O[C@@H]1C[C@@H](c2ccccc2)C1)c1ccccc1>>O[C@@H]1C[C@@H](c2ccccc2)C1,,CO,,[Li+].[OH-],,val
US20060241115A1,COC(=O)c1cccc2cc(Nc3ncnc4cc(OC)c(OC)cc34)ccc12>>COc1cc2ncnc(Nc3ccc4c(C(=O)O)cccc4c3)c2cc1OC,,CO,,[Na+].[OH-],,val
US20100004269A1,COC(=O)c1ccc(CNC=O)nc1Nc1ccc(SC)cc1F>>COC(=O)c1ccc2cncn2c1Nc1ccc(SC)cc1F,,Cc1ccccc1,,O=P(Cl)(Cl)Cl,,val
US20150240037A1,C=CC(=O)OCCOC(=O)c1cncc(C(=O)OCCOC(=O)C=C)c1.CI>>C=CC(=O)OCCOC(=O)c1cc(C(=O)OCCOC(=O)C=C)c[n+](C)c1.[I-],,CC#N,,,,val
US06380387B1,CCn1c(C)c(-c2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)OC)cc2)c(=O)n(CC)c1=O>>CCn1c(C)c(-c2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)O)cc2)c(=O)n(CC)c1=O,,CCO,,[Na+].[OH-],,val
US04410520,CC(C(=O)OC(C)(C)C)N1C(=O)C(N=[N+]=[N-])CCc2ccccc21>>CC(C(=O)OC(C)(C)C)N1C(=O)C(N)CCc2ccccc21,[Pd],CCO,,,,val
US06500846B1,Nc1ccc2oc(-c3ccc4c(c3)OCO4)c(O)c(=O)c2c1.O=C(Cl)c1ccccc1>>O=C(Nc1ccc2oc(-c3ccc4c(c3)OCO4)c(O)c(=O)c2c1)c1ccccc1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US06187777B1,Cc1nc(Cl)c2nc(-c3ccccc3)cc-2[nH]1.OC[C@@H]1CCCN1>>Cc1nc(N2CCC[C@H]2CO)c2nc(-c3ccccc3)cc-2[nH]1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20090291938A1,CC1(C)CN(C2CCCCC2)c2nc(Cl)ncc2NC1=O.CI>>CN1C(=O)C(C)(C)CN(C2CCCCC2)c2nc(Cl)ncc21,,CC(=O)N(C)C,,[H-].[Na+],,val
US05041455,CCC/C=C/COc1nsnc1-c1cccnc1.CI>>CCC/C=C/COc1nsnc1-c1ccc[n+](C)c1.[I-],,CC(C)=O,,,,val
US20030149018A1,CC(=O)n1ncc2c(OCCCl)cccc21>>ClCCOc1cccc2[nH]ncc12,,CO,,Cl,,val
US20070099990A1,Cc1cc2c(c(OCC(=O)c3ccc(C(C)C)cc3)c1)CCC2>>Cc1cc2c(c3occ(-c4ccc(C(C)C)cc4)c13)CCC2,,CO,,,,val
US20140213581A1,CC(C)(C)S(=O)N[C@@](C)(CS(=O)(=O)C1(C#N)CCC1)c1cc(Br)cnc1F>>C[C@](N)(CS(=O)(=O)C1(C#N)CCC1)c1cc(Br)cnc1F,,CO,,CCOCC,Cl,val
US20020165241A1,BrBr.COc1nccnc1NCC1CCN(C(=O)OC(C)(C)C)CC1>>COc1nc(Br)cnc1NCC1CCN(C(=O)OC(C)(C)C)CC1,,ClC(Cl)Cl,O,c1ccncc1,,val
US20010056109A1,COc1ccc(CC(C(=O)O)c2ccccc2)cc1.O=S(Cl)Cl>>COc1ccc(CC(C(=O)Cl)c2ccccc2)cc1,,ClCCl,,,,val
US20060173034A1,CCc1ccccc1Nc1c(C(N)=O)cnc2cc(O)c(OC)cc12.OCCN1CCNCC1>>CCc1ccccc1Nc1c(C(N)=O)cnc2cc(OCCN3CCNCC3)c(OC)cc12,,C1CCOC1,ClCCl,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05192781,CCCc1nc(COC)sc1Cc1ccc([N+](=O)[O-])cc1>>CCCc1nc(COC)sc1Cc1ccc(N)cc1,[Ni],CO,,O,,val
US04639264,CCOC(=S)SCc1cc(OC)nc(N)n1.COC(=O)c1ccccc1S(=O)(=O)N=C=O>>CCOC(=S)SCc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ccccc2C(=O)OC)n1,,CC#N,,,,val
US20060030613A1,CC(C)(C)c1ccc(CN)cc1.Cc1ccc(C(C)CC=O)o1>>Cc1ccc(C(C)CCNCc2ccc(C(C)(C)C)cc2)o1,Cl,CO,,[BH4-].[Na+],,val
US20040122039A1,CCCC[Sn](CCCC)(CCCC)c1nccs1.COc1cc(Br)cc(C)c1-c1cccc2c(N(CC3CC3)CC3CC3)c(SC)nn12>>COc1cc(-c2nccs2)cc(C)c1-c1cccc2c(N(CC3CC3)CC3CC3)c(SC)nn12,,Cc1ccccc1,,CCOC(C)=O,,val
US07012074B2,CC(C)(C)OC(=O)N1CC2CCC(C1)N2Cc1ccccc1.Cl>>CC(C)(C)OC(=O)N1CC2CCC(C1)N2.Cl,[Pd],CO,,[H][H],,val
US20160168090A1,Cc1ccc(S(=O)(=O)OCC2CCCCO2)cc1.O=C(c1c[nH]c2cccc(Cl)c12)C(F)(F)F>>O=C(c1cn(CC2CCCCO2)c2cccc(Cl)c12)C(F)(F)F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04988808,CCOC(=O)C1=Cc2c3nc(cc4[nH]c(cc5[nH]c(cc6nc2C1(CC)C6CC)c(CC)c5CC)c(CC)c4CC)C(CC)=C3CC>>C1=Cc2cc3ccc(cc4nc(cc5ccc(cc1n2)[nH]5)C=C4)[nH]3,,ClCCl,,,,val
US20100173924A1,Cc1ccc(C(=O)O)cc1Br.Nc1ccc(CCN2CCCC2)cc1>>Cc1ccc(C(=O)Nc2ccc(CCN3CCCC3)cc2)cc1Br,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US06333337B1,O=C(OO)c1cccc(Cl)c1.O=[N+]([O-])c1ccc2c(c1)C=CCC2>>O=[N+]([O-])c1ccc2c(c1)C1=C(CC2)O1,,ClCCl,,O=C([O-])O.[Na+],,val
US20130303517A1,Br[Mg]C1CC1.CON(C)C(=O)c1ccc2nc(-c3ccc(F)cc3)c(CCCCC(=O)OC(C)(C)C)nc2c1>>CC(C)(C)OC(=O)CCCCc1nc2cc(C(=O)C3CC3)ccc2nc1-c1ccc(F)cc1,,C1CCOC1,,,,val
US05145865,CC(C)CBr.COC(=O)c1ccc(OCC2CC(=O)N(c3ccc(O)cc3)C2)cc1>>COC(=O)c1ccc(OCC2CC(=O)N(c3ccc(OCC(C)C)cc3)C2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050009900A1,COC(=O)c1cc(-c2ccc(C)nc2)ccc1Cl>>Cc1ccc(-c2ccc(Cl)c(C(=O)O)c2)cn1,,[K+],[OH-],Cl,,val
US20100113444A1,CCOC(=O)CNC(=O)c1c(O)[nH]c(=O)n(Cc2ccccc2)c1=O.Clc1cccc(Cl)c1CBr>>O=C(O)CNC(=O)c1c(O)n(Cc2c(Cl)cccc2Cl)c(=O)n(Cc2ccccc2)c1=O,,CN(C)C=O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20130102776A1,COc1ccc2c(c1CCC1CCN(C(=O)OC(C)(C)C)CC1)O/C(=C\c1n[nH]c3ncccc13)C2=O>>COc1ccc2c(c1CCC1CCNCC1)O/C(=C\c1n[nH]c3ncccc13)C2=O,,C1COCCO1,ClCCl,Cl,,val
US20100093724A1,CC(O)c1ccnc(Br)c1>>CC(=O)c1ccnc(Br)c1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20070129347A1,CN(C)C1(c2ccccn2)CCC(=CC(=O)NCCCc2ccccc2)CC1.C[Si](C)(C)Cl>>CN(C)C1(c2ccccn2)CCC(=CC(=O)NCCCc2ccccc2)CC1.Cl,,CCC(C)=O,,,,val
US20150329538A1,CS(=O)(=O)Cl.Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1N[C@H]1CCC[C@@H](N)C1>>Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1N[C@H]1CCC[C@@H](NS(C)(=O)=O)C1,,ClCCl,,CCN(CC)CC,,val
US20100144710A1,CC(C)Br.N#Cc1cccnc1N1CCN(C(=O)Cc2ccc(O)cc2)CC1>>CC(C)Oc1ccc(CC(=O)N2CCN(c3ncccc3C#N)CC2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05208259,Cc1ccc(I)cc1Cl.O=C1CCC(=O)N1Br>>Clc1cc(I)ccc1CBr,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20110003787A1,COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)nn2)cc(-c2ccc(C3=NC[C@H](C)O3)[nH]2)c1>>C[C@H]1CN=C(c2ccc(-c3cc(Oc4ccc(S(C)(=O)=O)nn4)cc(O[C@@H](C)CO)c3)[nH]2)O1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20100004301A1,Cc1cc(C)cc(-c2ccc(Br)cc2-c2nc3cc(C)ccc3o2)c1.NC(=O)c1ccccc1OC(F)(F)F>>Cc1cc(C)cc(-c2ccc(NC(=O)c3ccccc3OC(F)(F)F)cc2-c2nc3cc(C)ccc3o2)c1,[Cu]I,CCOC(C)=O,Cc1ccccc1,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US05399542,C=CCN1C(=O)COc2ccc(C3CC(=O)C(C(=O)CC)=C(O)C3)cc21.CCON>>C=CCN1C(=O)COc2ccc(C3CC(=O)C(C(CC)=NOCC)=C(O)C3)cc21,,CS(C)=O,O,Cl,CC(=O)[O-].[Na+],val
US20140323475A1,CC1(CO)COC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC1(COS(=O)(=O)C(F)(F)F)COC1,,ClCCl,,O=C([O-])O.[Na+],,val
US20060111387A1,CC(C)(N)CNc1c([N+](=O)[O-])cnc2cc(-c3ccccc3)ccc12.CS(=O)(=O)OS(C)(=O)=O>>CC(C)(CNc1c([N+](=O)[O-])cnc2cc(-c3ccccc3)ccc12)NS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US07015218B1,Cc1oncc1C(=O)N1CCN(c2ccc(NC(=O)c3cnn(-c4ccc(F)cc4)c3C)cc2C#N)CC1>>C/C(O)=C(\C#N)C(=O)N1CCN(c2ccc(NC(=O)c3cnn(-c4ccc(F)cc4)c3C)cc2C#N)CC1,,O,,CCO,[Na+].[OH-],val
US05356917,CCO.NCCO.S=C=S>>O=C1CSC(=S)N1CCO,,CCO,,CCOCC,,val
US20120295903A1,BrCCCc1cccnc1.Cc1cc(N)c([N+](=O)[O-])cc1C>>Cc1cc(NCCCc2cccnc2)c([N+](=O)[O-])cc1C,,CN(C)C=O,,[H-].[Na+],,val
US20090182140A1,COC([O-])[O-].CSc1nc(NN)c(C(N)=O)c(NCc2ccc(Cl)cc2Cl)n1>>CSc1nc(NCc2ccc(Cl)cc2Cl)c(C(N)=O)c2nncn12,,CN(C)C=O,,,,val
US20110009381A1,CCOC(=O)c1cc(OCCN2CCOCC2)cc(-c2ccccc2)n1>>O=C(O)c1cc(OCCN2CCOCC2)cc(-c2ccccc2)n1,,C1CCOC1,CO,[Li+].[OH-],,val
US05200415,CCCc1cccc2c(C(=O)OCC)cnn12>>CCCc1cccc2c(C(=O)O)cnn12,,CCO,,[Na+].[OH-],,val
US20090197871A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc(Br)cc1C#N>>COc1ccc(Br)cc1CNC(=O)OC(C)(C)C,Cl[Ni]Cl,CCO,,[BH4-].[Na+],,val
US03962277,C[Si](C)(C)Cl.O=C1CCC(=O)N1>>C[Si](C)(C)N1C(=O)CCC1=O,,Cc1ccccc1,,CCN(CC)CC,,val
US20120245210A1,COc1ccc(-c2scc(CCC(=O)O)c2-c2ccc(C#N)cc2C)cc1.OO>>COc1ccc(-c2scc(CCC(=O)O)c2-c2ccc(C(N)=O)cc2C)cc1,,CS(C)=O,,[Na+].[OH-],,val
US20080146642A1,NCCCS(N)(=O)=O.O=C(c1ccc(Cl)cc1)c1cc(F)ccc1O>>NS(=O)(=O)CCC/N=C(\c1ccc(Cl)cc1)c1cc(F)ccc1O,,CO,,,,val
US20080269196A1,N#Cc1ccc(-n2ccc(NCC3CC3)n2)cc1>>NCc1ccc(-n2ccc(NCC3CC3)n2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080312226A1,Nc1ncccn1.O=C(Cl)OCC(Cl)(Cl)Cl>>O=C(Nc1ncccn1)OCC(Cl)(Cl)Cl,,CC(=O)N(C)C,,c1ccncc1,,val
US20100210674A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1Nc2cc(Cl)ccc2/C1=C/c1ccsc1>>CC(C)(C)OC(=O)N1C(=O)/C(=C\c2ccsc2)c2ccc(Cl)cc21,CN(C)c1ccncc1,ClCCl,,,,val
US04432896,CCOC(=O)[C@H](Cc1ccccc1OC(C)=O)NC(=O)CNC(=O)c1ccccc1>>O=C(CNC(=O)c1ccccc1)N[C@@H](Cc1ccccc1O)C(=O)O,,CO,,[Na+].[OH-],,val
US20130072467A1,NCCOCCO.O=C1NC(=S)CS1>>O=C1N=C(NCCOCCO)CS1,,CC(C)O,CCOC(C)=O,,,val
US04667032,BrBr.COc1ccc2nc3c(OC)cc(=O)cc-3sc2c1>>COc1ccc2nc3c(OC)cc(=O)c(Br)c-3sc2c1,,CC(=O)O,,CO,,val
US20130079341A1,CCOC(=O)CNc1sc(C(=O)OC)cc1[N+](=O)[O-]>>COC(=O)c1cc2c(s1)NCC(=O)N2,[Fe],CC(=O)O,O,,,val
US20020183350A1,COc1ccc([C@@H]2CC=CC[C@@H]2[N+](=O)[O-])cc1OC>>COc1ccc([C@@H]2CCCC[C@@H]2[N+](=O)[O-])cc1OC,[Pd],CO,,Cl,,val
US05275950,CC[C@@H](O)[C@@H](O)C=C(C)C.COC(C)(C)OC>>C=C[C@H]1OC(C)(C)O[C@H]1CC(C)C,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20150087663A1,CCc1nc(-c2c(N)ncnc2Cl)no1.C[C@H](N)c1nc2cccc(Cl)c2c(=O)n1C1CC1>>CCc1nc(-c2c(N)ncnc2N[C@@H](C)c2nc3cccc(Cl)c3c(=O)n2C2CC2)no1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US06166064,CSc1cccc(S(N)(=O)=O)c1.O=C1CCC(=O)N1Cl>>CS(=O)c1cccc(S(N)(=O)=O)c1,,CO,,,,val
US05366988,CC(C)(C)CCOc1cccc(C(=NO)n2cncn2)c1.CC(C)I>>CC(C)ON=C(c1cccc(OCCC(C)(C)C)c1)n1cncn1,,CN(C)C=O,,O,[H-].[Na+],val
US20010014737A1,CC(C)(C)OC(=O)NC(=O)OC(C)(C)C.COc1ccc(Br)c(CBr)c1>>COc1ccc(Br)c(CN(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1,,CN(C)C=O,,[K],,val
US20140213599A1,CC(C)I.CC1(C)Cn2c(cc(Cl)nc2=O)N1>>CC(C)N1c2cc(Cl)nc(=O)n2CC1(C)C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160102105A1,O=C(Cl)C(=O)Cl.O=C(O)c1nn(C(F)F)cc1Cl>>O=C(Cl)c1nn(C(F)F)cc1Cl,,ClCCl,,CN(C)C=O,,val
US05880147,CCCCC(CC(=O)OC)c1ccc(O)cc1OC.COCCCOS(=O)(=O)c1ccc(C)cc1>>CCCCC(CC(=O)O)c1ccc(OCCCOC)cc1OC,,CCOCC,,,,val
US20140275104A1,CC(C)(C)c1nc(C2CCC2)cc(N2CCN(CC[C@@H]3CC[C@@H](N)CC3)CC2)n1.O=C(O)[C@@H]1CC[C@@H](O)CC1>>CC(C)(C)c1nc(C2CCC2)cc(N2CCN(CC[C@@H]3CC[C@@H](NC(=O)[C@@H]4CC[C@@H](O)CC4)CC3)CC2)n1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05889012,CC1([C@@H]2CC[C@H](N)CC2)CC1.CCc1ncnc(Cl)c1Cl>>CCc1ncnc(N[C@H]2CC[C@@H](C3(C)CC3)CC2)c1Cl,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20110262359A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N[C@@H](CCC(=O)OCc1ccccc1)C(=O)NCc1ccc(C(=N)NO)cc1>>CC(=O)N(O)C(=N)c1ccc(CNC(=O)[C@H](CCC(=O)OCc2ccccc2)NC(=O)OC(C)(C)C)cc1,,CC(=O)O,,,,val
US20120316151A1,CC(C)(C)OC(=O)N1CC[C@H](CC(=O)O)C1.CCO>>CCOC(=O)C[C@H]1CCN(C(=O)OC(C)(C)C)C1,CN(C)c1ccncc1,CCOCC,CCOCC,CCN=C=NCCCN(C)C,Cl,val
US20150299143A1,COC(=O)c1c[nH]cn1.O=C1c2ccccc2C(=O)N1CCBr>>COC(=O)c1cn(CCN2C(=O)c3ccccc3C2=O)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20010051622A1,O=C(O)[C@H]1CN(C(=O)OCc2ccccc2)CCN1c1cc(Cl)c(Cl)cc1[N+](=O)[O-]>>O=C1Nc2cc(Cl)c(Cl)cc2N2CCNC[C@H]12,[Fe],CC(=O)O,,,,val
US20160159773A1,CC(C)(C)OC(=O)N[C@H]1CCCC[C@@H]1Nc1ccc(Nc2cc(N3CC[C@@](C#N)(C4CC4)C3=O)ccn2)nc1.Cl>>Cl.N#C[C@@]1(C2CC2)CCN(c2ccnc(Nc3ccc(N[C@H]4CCCC[C@@H]4N)cn3)c2)C1=O,,CO,,CCOC(C)=O,,val
US20150225412A1,CC(C)(C)OC(=O)N1CCC[C@@H]1CNc1ccccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)N1CCC[C@@H]1CNc1ccccc1N,[Pd],CO,,,,val
US20160222012A1,C=CCC(N=[N+]=[N-])c1cc2ccc(F)cc2nc1Cl>>Fc1ccc2cc(C3CCCN3)c(Cl)nc2c1,,C1CCOC1,,C1=CCCCC1,,val
US20060122197A1,O=C1C2CC3CC1CC(C(=O)N[C@H]1CCCN(C(=O)OCc4ccccc4)C1)(C3)C2>>O=C(OCc1ccccc1)N1CCC[C@H](NC(=O)C23CC4CC(C2)C(O)C(C4)C3)C1,,CCOC(C)=O,,CO,[BH4-].[Na+],val
US20130137672A1,CC(C)(C)OC(=O)N1CCC2CNC2C1.Cc1nc(-c2ccccc2F)c(C(=O)O)s1>>Cc1nc(-c2ccccc2F)c(C(=O)N2CC3CCN(C(=O)OC(C)(C)C)CC32)s1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160096827A1,N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)cc(F)c1O[C@H]1CCNC[C@H]1F.O=C(O)c1coc(=O)[nH]1>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@H]1CCN(C(=O)c2coc(=O)[nH]2)C[C@H]1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120238517A1,C=CCNC(=O)OC(C)(C)C.C=O.ONCc1ccccc1>>CC(C)(C)OC(=O)NCC1CCN(Cc2ccccc2)O1,,CCN(CC)CC,Cc1ccccc1,CCO,Cl,val
US20070208017A1,CC(=O)Cc1ccc2c(c1)c1cc(Cl)ccc1c1c2nc(-c2c(C#N)cccc2C#N)n1COCC[Si](C)(C)C.[Li]C>>CC(C)(O)Cc1ccc2c(c1)c1cc(Cl)ccc1c1c2nc(-c2c(C#N)cccc2C#N)n1COCC[Si](C)(C)C,Cl[Ti](Cl)(Cl)Cl,CCOCC,,,,val
US20070117816A1,Cc1cnc(F)c(-c2c([N+](=O)[O-])cc(C#N)cc2[N+](=O)[O-])c1>>Cc1cnc(F)c(-c2c(N)cc(C#N)cc2N)c1,[Fe],CC(=O)O,,O,,val
US05234924,O=C(Cl)CBr.O=S1C=Nc2ccccc21>>O=C(CBr)c1ccc2c(c1)S(=O)C=N2,,CN(C)C=O,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04066772,O=c1[nH]c2cc(Cl)ccc2n1C1CCNCC1.O=c1[nH]c2ccccc2n1CCCCl>>O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1,,CC(=O)CC(C)C,O,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20040082607A1,CCCCO.CCOC(=O)c1c(O)c2cc(F)ccc2c(=O)n1CC(C)(C)C>>CCCCOc1c(C(=O)OCC)n(CC(C)(C)C)c(=O)c2ccc(F)cc12,,C1CCOC1,,CCCCP(CCCC)CCCC,,val
US20150087646A1,NC(=O)c1cc(CNC(=O)C(F)(F)F)c(F)cc1Cl.O=C(Cl)C(=O)Cl>>O=C=NC(=O)c1cc(CNC(=O)C(F)(F)F)c(F)cc1Cl,,ClCCCl,,,,val
US20040024010A1,COc1cc(C=C2C(=O)Nc3ccccc32)cc(Br)c1OC.COc1ccccc1B(O)O>>COc1cc(C=C2C(=O)Nc3ccccc32)c(-c2ccccc2OC)cc1OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],val
US20060217380A1,Nc1cc(C(F)(F)F)ccc1Br.O.OB(O)c1cccnc1>>O=[N+]([O-])c1cc(C(F)(F)F)ccc1-c1cccnc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US06232310B1,COc1ccc(NC(C)=O)c(SSc2cc(OC)ccc2NC(C)=O)c1.N#CCI>>COc1ccc(NC(C)=O)c(SCC#N)c1,,CCO,,[BH4-].[Na+],,val
US05374772,COC(=O)c1cc(OCCCOc2ccc(OCc3ccccc3)cc2)cc(OCCCOc2ccc(OCc3ccccc3)cc2)c1>>O=C(O)c1cc(OCCCOc2ccc(OCc3ccccc3)cc2)cc(OCCCOc2ccc(OCc3ccccc3)cc2)c1,,C1COCCO1,CO,[Na+].[OH-],,val
US20030171400A1,CC(C)CC=O.COc1ccc(-c2ccc(S(=O)(=O)NC3(C(=O)O)CCNCC3)cc2)cc1.c1ccncc1>>COc1ccc(-c2ccc(S(=O)(=O)NC3(C(=O)O)CCN(CCc4ccccc4)CC3)cc2)cc1,,CCO,,Cl,,val
US20020143186A1,CC1(C)OC(=O)[C@H](CC(=O)O)O1.OCc1ccccc1.[N-]=[N+]=NP(=O)(Oc1ccccc1)Oc1ccccc1>>CC1(C)OC(=O)[C@H](CNC(=O)OCc2ccccc2)O1,,Cc1ccccc1,,CCN(CC)CC,,val
US06037354,C1=C(c2ccccn2)CCC2(C1)OCCO2>>c1ccc(C2CCC3(CC2)OCCO3)nc1,[Pd],CCOC(C)=O,,,,val
US20030083238A1,COCCCCCOC1CCNCC1.N#Cc1ccc(F)cc1>>COCCCCCOC1CCN(c2ccc(C#N)cc2)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04447425,CC(=O)OC(C)=O.C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC[C@@H](O)C[C@@]43C)[C@@H]1C[C@H](N1CCCCC1)[C@@H]2O>>CC(=O)O[C@H]1[C@@H](N2CCCCC2)C[C@H]2[C@@H]3CC[C@H]4CC[C@@H](O)C[C@]4(C)[C@H]3CC[C@@]21C,,c1ccncc1,,,,val
US20140141034A1,CCOC(=O)NN.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.[N-]=[N+]=NCCOCCOCCOCCN>>CCOC(=O)NNC(=O)NCCOCCOCCOCCN=[N+]=[N-],,C1CCOC1,O,CCN(CC)CC,,val
US20110288067A1,CC(=O)Cl.C[Si](C)(C)CCOCn1cc(C(=O)NCC2CCCNC2)c2nc(C3CC3)cnc21>>CC(=O)N1CCCC(CNC(=O)c2cn(COCC[Si](C)(C)C)c3ncc(C4CC4)nc23)C1,,ClCCl,,CCN(CC)CC,Cl,val
US04882350,BrCc1ccccc1.CC(C)OC1CCC(=O)N1>>CC(C)OC1CCC(=O)N1Cc1ccccc1,,C1CCOC1,,[K+].[OH-],,val
US20130084346A1,Nc1cccc(-c2ccccc2)c1.O=C(O)c1cc(=O)c(OCc2ccccc2)co1>>O=c1ccn(-c2cccc(-c3ccccc3)c2)cc1OCc1ccccc1,,c1ccc(Oc2ccccc2)cc1,,,,val
US20150183802A1,COC(=O)CNCc1ccc(F)c(OC)c1.Cc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)CN(Cc1ccc(F)c(OC)c1)S(=O)(=O)c1ccc(C)cc1,CN(C)c1ccncc1,ClCCl,O,CCN(CC)CC,,val
US20090163471A1,COC(=O)c1cc(NC(C)C)c(C#N)cc1C.OO>>COC(=O)c1cc(NC(C)C)c(C(N)=O)cc1C,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080146565A1,CC(C)[Si](Oc1cccc2[nH]ccc12)(C(C)C)C(C)C.CSc1nccc(Cl)n1>>CSc1nccc(-n2ccc3c(O[Si](C(C)C)(C(C)C)C(C)C)cccc32)n1,,CN(C)C=O,,[H-].[Na+],,val
US20080207654A1,CCCCc1nc(C)c(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1F.O=C([O-])O.[NH3+]O>>CCCCc1nc(C)c(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1F,,O,,CS(C)=O,[Cl-].[Na+],val
US06878704B2,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(C(=O)OC(C)(C)C)CC3)cc21,,C1CCOC1,O,[Na+].[OH-],,val
US20060178377A1,CC(=O)C(=Cc1ccc(Cl)cc1Cl)C(N)=O.Nc1nc(S(=O)(=O)O)c[nH]1>>CC1=C(C(N)=O)C(c2ccc(Cl)cc2Cl)n2cc(S(=O)(=O)O)nc2N1,,CCO,O,,,val
US20140309210A1,CC(C)(c1cccc(C#N)c1)n1cc([N+](=O)[O-])cn1>>CC(C)(c1cccc(C#N)c1)n1cc(N)cn1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20100311966A1,CCCCOC(=O)c1nc(N2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)[C@H](OCC)C2)oc1C>>CCO[C@@H]1CN(c2nc(C(=O)O)c(C)o2)CC[C@@H]1NC(=O)c1nc(Cl)c(CC)[nH]1,,C1CCOC1,,CO,[Li+].[OH-],val
US20020099089A1,COC(=O)c1ccccc1NC(=O)CC(C)c1ccc2ccccc2c1>>CC(CC(=O)Nc1ccccc1C(=O)O)c1ccc2ccccc2c1,,CO,,[Na+].[OH-],,val
US20080207728A1,COC(=O)c1cc(-c2cc(OC)c(OC)c(OC)c2)cc2c1OCC=C2>>COc1cc(-c2cc3c(c(C(=O)O)c2)OCC=C3)cc(OC)c1OC,,[K+],[OH-],,,val
US20110118245A1,CC(C)(C)c1cc(NC(=O)Oc2ccccc2)n(-c2ccccc2)n1.COc1cc2ncnc(Sc3cccc(N)c3)c2cc1OC>>COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccccc4)c3)c2cc1OC,CN(C)c1ccncc1,,,CCN(C(C)C)C(C)C,,val
US05693827,CC(C)OC(=O)c1ccc(F)c(N)c1.CC1=C(C(=O)O)SCCO1>>CC1=C(C(=O)Nc2cc(C(=O)OC(C)C)ccc2F)SCCO1,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20040116328A1,CNC.Cn1nc(Cl)c2c(ncn2Cc2ccccc2)c1=O>>CN(C)c1nn(C)c(=O)c2ncn(Cc3ccccc3)c12,,CCO,,,,val
US20020123496A1,COC(=O)CBr.COc1ccc(C(=O)Cc2ccncc2)cc1>>COC(=O)CC(C(=O)c1ccc(OC)cc1)c1ccncc1,,C1CCOC1,Cc1ccccc1,CC(C)[N-]C(C)C.[Li+],,val
US20120122843A1,CN(Cc1ccc(Cl)nc1Cl)CC(O)CC(CF)CF>>CN1Cc2ccc(Cl)nc2OC(CC(CF)CF)C1,,C1CCOC1,,[H-].[Na+],,val
US05541186,COc1ccc(Cl)c(Oc2c(NS(=O)(=O)c3ccc4c(c3)OCCO4)ncnc2OCCO)c1.O=C=Nc1cccnc1>>COc1ccc(Cl)c(Oc2c(NS(=O)(=O)c3ccc4c(c3)OCCO4)ncnc2OCCOC(=O)Nc2cccnc2)c1,,Cc1ccccc1,,,,val
US20080015202A1,CC(=O)Nc1nc(CCc2ccc(CCNC(NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)s2)cs1>>CC(=O)Nc1nc(CCc2ccc(CCNC(=N)N)s2)cs1,,C1COCCO1,,CO,Cl,val
US20100234340A1,COC(=O)c1[nH]cnc1CN(CCO)Cc1ccccc1.O=S(Cl)Cl>>COC(=O)c1[nH]cnc1CN(CCCl)Cc1ccccc1,,ClCCl,,,,val
US20050228155A1,C1=CC(=CC2CCCCC2)C=C1.CC(C)(C)c1ccc2c(c1)-c1cc(C(C)(C)C)ccc1C2>>CC(C)(C)c1ccc2c(c1)-c1cc(C(C)(C)C)cc(C3(C4C=CC=C4)CCCCC3)c1C2,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20120238561A1,CNc1nc(N2C[C@H](C)O[C@H](C)C2)sc1-c1cc(C)nc(C)c1.Cc1cc(C(=O)Cl)on1>>Cc1cc(C(=O)NCc2nc(N3C[C@H](C)O[C@H](C)C3)sc2-c2cc(C)nc(C)c2)on1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US07723371B2,O=CNc1ccccc1C1(O)CC(C2CC2)C1>>Nc1ccccc1C1(O)CC(C2CC2)C1,,CO,,[K+].[OH-],,val
US20150018343A1,CCOC(=O)c1ccccc1F.CN(C)Cc1ncc[nH]1>>CCOC(=O)c1ccccc1-n1ccnc1CN(C)C,,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US06248755B1,c1ccc(Cc2cnn(C3CCN(Cc4ccccc4)CC3)n2)cc1>>c1ccc(Cc2cnn(C3CCNCC3)n2)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US20150210688A1,COC(=O)c1ccc(C2CC2)c(Br)c1>>O=C(O)c1ccc(C2CC2)c(Br)c1,,CO,O,[Na+].[OH-],,val
US06355653B1,CCOC(=N)CS(=O)(=O)c1ccccc1.NNC(=O)c1ccco1>>NC(CS(=O)(=O)c1ccccc1)=NNC(=O)c1ccco1,,ClC(Cl)Cl,,Cl,[Na+].[OH-],val
US20130040930A1,Cc1ccc(N2CCN(C(=O)c3ccc(N4CC(CN5CCCC5)CC4=O)cc3)CC2)c(C)c1.Cl>>Cc1ccc(N2CCN(C(=O)c3ccc(N4CC(CN5CCCC5)CC4=O)cc3)CC2)c(C)c1.Cl,,CCOC(C)=O,,,,val
US20030153566A1,COc1ccc(N2C[C@@H]3C[C@H]2CO3)cc1[N+](=O)[O-]>>COc1ccc(N2C[C@@H]3C[C@H]2CO3)cc1N,[Pd],CO,ClCCl,,,val
US05712403,CC(C)(C)c1ccc(CO)c(O)c1.Cc1ccc(O)c(C(C)(C)C)c1>>Cc1cc(Cc2ccc(C(C)(C)C)cc2O)c(O)c(C(C)(C)C)c1,,O,,Cl,[Na+].[OH-],val
US20030158256A1,BrC(Br)(Br)Br.C=CCOC(=O)c1cccc(CO)n1>>C=CCOC(=O)c1cccc(CBr)n1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040009995A1,CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(Br)c1.Nc1cccc(B(O)O)c1>>CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(-c2cccc(N)c2)c1,,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20040097506A1,COC(C)(OC)N(C)C.Nc1ccc(Cl)nn1>>CC(=Nc1ccc(Cl)nn1)N(C)C,,Cc1ccccc1,,,,val
US20080167307A1,CCCCCCCNCCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1.Clc1nc2ncccc2o1.O=C(O)C(F)(F)F>>CCCCCCCN(CCc1csc(SC(C)(C)C(=O)O)n1)c1nc2ncccc2o1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05223505,CNc1nc(C)cc(N2CCc3ccccc32)n1>>CNc1nc(C)cc(-n2ccc3ccccc32)n1,[Pd],c1ccc(Oc2ccccc2)cc1,,,,val
US20120129842A1,CS(=O)(=O)Cl.Cc1nc(CO)sc1-c1csc(Nc2cc(C(N)=O)ccc2OC(C)C)n1>>Cc1nc(CCl)sc1-c1csc(Nc2cc(C(N)=O)ccc2OC(C)C)n1,,ClCCl,,CCN(CC)CC,,val
US20140051679A1,BrC1CC1.N#Cc1ccccc1Cl>>NC(c1ccccc1Cl)C1CC1,,CO,,C1CCOC1,[BH4-].[Na+],val
US20130310379A1,CC(Br)c1ccc(C(=O)NC2CC(C)(C)NC(C)(C)C2)cc1.Oc1ccccc1>>CC(Oc1ccccc1)c1ccc(C(=O)NC2CC(C)(C)NC(C)(C)C2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080161303A1,N#CBr.NNc1cc(Br)ccn1>>Nc1nnc2cc(Br)ccn12,,CC(C)O,,,,val
US20040014967A1,NC(=O)[C@H]1CN(c2ccc(N3CCN(C(=O)COCc4ccccc4)CC3)c(F)c2)C(=O)O1>>NC(=O)[C@H]1CN(c2ccc(N3CCN(C(=O)CO)CC3)c(F)c2)C(=O)O1,[Pd],CCO,CO,[H][H],,val
US20150203515A1,CC(C)(C)[C@@H]1CC[C@@H](Oc2ccc3cc(C=O)ccc3c2)CC1.NC12CCC(CO)(CC1)C(O)C2>>CC(C)(C)[C@@H]1CC[C@@H](Oc2ccc3cc(CNC45CCC(CO)(CC4)C(O)C5)ccc3c2)CC1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120129811A1,O=[N+]([O-])c1cccc2[nH]c(CO)nc12>>Nc1cccc2[nH]c(CO)nc12,[Pd],CO,,,,val
US20020028832A1,CC(C)(C)[Si](Oc1ccc(OC[C@@H](O)CNCCc2ccc(OC3CCN(C(=O)NCc4ccc(F)cc4)CC3)cc2)cc1)(c1ccccc1)c1ccccc1>>O=C(NCc1ccc(F)cc1)N1CCC(Oc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1,,CO,ClC(Cl)Cl,,,val
US20090247567A1,BrBr.O=C1CCCOc2cc(Br)ccc21>>O=C1c2ccc(Br)cc2OCCC1Br,,CCOCC,,,,val
US20050119326A1,BrCc1ccccc1.CCOC(=O)c1cc2ccccc2[nH]1>>CCOC(=O)c1cc2ccccc2n1Cc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060089358A1,C1CCOC1.CC#N.CCN(CC)CC.CN(C)C=O.ClC(Cl)Cl>>CCN(C(C)C)C(C)C.NCc1ccccc1,,CC#N,ClC(Cl)Cl,CC(=O)N(C)C,,val
US20100099658A1,CI.O=[N+]([O-])c1ccccc1S(=O)(=O)NC1CC1>>CN(C1CC1)S(=O)(=O)c1ccccc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040235896A1,CCOc1ccc(-c2ccc(S(=O)(=O)N[C@@H](C(=O)OCc3ccccc3)C3CCN(C(=O)OC(C)(C)C)CC3)s2)cc1.CI>>CCOc1ccc(-c2ccc(S(=O)(=O)N(C)[C@@H](C(=O)OCc3ccccc3)C3CCN(C(=O)OC(C)(C)C)CC3)s2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20020032208A1,O=c1[nH]cnc2cc(F)ccc12.Sc1ccncc1>>O=c1[nH]cnc2cc(Sc3ccncc3)ccc12,,CN(C)C=O,O,[H-].[Na+],,val
US20060183790A1,CCOC(=O)Cn1c(-c2ccccc2)ccc1-c1ccc(C(=O)N(C)Cc2ccccc2)cc1.N=C(N)N>>CN(Cc1ccccc1)C(=O)c1ccc(-c2ccc(-c3ccccc3)n2CC(=O)NC(=N)N)cc1,,CS(C)=O,,,,val
US05189054,CCOC(=O)c1[nH]c2cc(Cl)cc(Cl)c2c1N.ClCCl.O=C(Cl)c1ccccc1F>>CCOC(=O)c1[nH]c2cc(Cl)cc(Cl)c2c1NCC(=O)c1ccccc1F,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20120264734A1,CCN(c1cc(-c2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)nc2)cc(C(=O)NCc2c(C(C)C)c(F)c(C)[nH]c2=O)c1C)C1CCOCC1>>CCN(c1cc(-c2ccc(N3CCNCC3)nc2)cc(C(=O)NCc2c(C(C)C)c(F)c(C)[nH]c2=O)c1C)C1CCOCC1.O=CO,,CCO,,C1COCCO1,Cl,val
US20120015943A1,COC(=O)c1ccc2c(c1)C(O)CCC2>>COC(=O)c1ccc2c(c1)C=CCC2,,Cc1ccccc1,,,,val
US20050209338A1,Nc1cccc(I)c1.O=C=NC(=O)c1ccccc1>>O=C(NC(=O)c1ccccc1)Nc1cccc(I)c1,,ClCCl,,CO,,val
US20110053909A1,CC(=O)Cl.CC(C)(C)[Si](C)(C)OCCc1csc(CCO)c1>>CC(=O)OCCc1cc(CCO[Si](C)(C)C(C)(C)C)cs1,,C1CCOC1,,CCN(CC)CC,,val
US04367238,COS(=O)(=O)OC.O=Cc1cccc(Sc2ccccc2Cl)c1O>>COc1c(C=O)cccc1Sc1ccccc1Cl,,[K+],[OH-],,,val
US20150259323A1,CCOC(=O)c1ccc(N2CCC[C@@H](Oc3ccccc3OCC)C2)nc1>>CCOc1ccccc1O[C@@H]1CCCN(c2ccc(C(=O)O)cn2)C1,,C1CCOC1,O,[Na+].[OH-],,val
US20130281452A1,CCc1cc(Br)cc(CC)c1C(=O)O.NCc1ccc(Cl)cc1>>CCc1cc(Br)cc(CC)c1C(=O)NCc1ccc(Cl)cc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US08399444B2,CCOC(=O)CC1CCCCc2nc(C(C)C)n(Cc3ccc(Cl)cc3)c21>>CC(C)c1nc2c(n1Cc1ccc(Cl)cc1)C(CC(=O)O)CCCC2,,CO,,[Na+].[OH-],,val
US20100152160A1,CCOC(=O)C1CNc2cc(Cl)ccc2O1.II>>CCOC(=O)C1CNc2cc(Cl)c(I)cc2O1,,CC(=O)O,,,,val
US05179212,CS(=O)(=O)OCC(O)CC#N.Cl>>CS(=O)(=O)OCC(O)CCN.Cl,[Pd],CO,,[H][H],,val
US20160039825A1,N#CC(N)c1cc2n(n1)CCCN(C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2.OO>>NC(=O)C(N)c1cc2n(n1)CCCN(C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2,,CO,CS(C)=O,[Na+].[OH-],,val
US20150210682A1,CCOC=C(C(C)=O)C(=O)OCC.CCOc1cc2c(cc1Cl)C=NC(CC)C2>>CCOC(=O)C1=CN2C(CC)Cc3cc(OCC)c(Cl)cc3C2CC1=O,,CCO,,,,val
US20120136013A1,BrCc1ccc(-c2ccccn2)cc1.CC(C)Cn1c(=O)n(C)c(=O)c2c[nH]cc21>>CC(C)Cn1c(=O)n(C)c(=O)c2cn(Cc3ccc(-c4ccccn4)cc3)cc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130296363A1,Cc1cc(Nc2nc(S(=O)c3ccc(F)cc3)cc3ccccc23)nn1C(=O)OC(C)(C)C>>Cc1cc(Nc2nc(S(=O)c3ccc(F)cc3)cc3ccccc23)n[nH]1,,CCOC(C)=O,,C1COCCO1,Cl,val
US20100137281A1,CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccc(F)cc4C#N)cc3)c2s1.O=C([O-])O.[NH3+]O>>CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccc(F)cc4-c4noc(=O)[nH]4)cc3)c2s1,,ClC(Cl)Cl,,CS(C)=O,[Cl-].[Na+],val
US20040259883A1,CC(C)(C)OC(=O)N1CCC(N)CC1.O=[N+]([O-])c1cc(C(F)(F)F)ccc1F>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(C(F)(F)F)cc2[N+](=O)[O-])CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20040254205A1,COc1cc2ncnc3c2c(c1OC)CC(CI)N3c1ccccc1>>COc1cc2ncnc3c2c(c1OC)C=C(C)N3c1ccccc1,,Cc1ccccc1,ClC(Cl)Cl,C1CCC2=NCCCN2CC1,,val
US20060069095A1,ClCCN1CCOCC1.FC(F)(F)Oc1ccc(/C=C/c2nc(COc3ccc(CCCCc4c[nH]nn4)cc3)co2)cc1>>FC(F)(F)Oc1ccc(/C=C/c2nc(COc3ccc(CCCCc4cnn(CCN5CCOCC5)n4)cc3)co2)cc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20150259316A1,CCOC(=O)CC(=O)c1ccccc1.COc1ccc(C=O)c(O)c1>>COc1ccc2cc(C(=O)c3ccccc3)c(=O)oc2c1,,CCO,,,,val
US06399629B1,CC(C)(C)OC(=O)NCC(=O)N[C@@H]1C[C@@H](CO)N(C(=O)OC(C)(C)C)C1.Oc1ccc(-c2ccccc2)cc1>>CC(C)(C)OC(=O)NCC(=O)N[C@@H]1C[C@@H](COc2ccc(-c3ccccc3)cc2)N(C(=O)OC(C)(C)C)C1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090042852A1,C1C[NH2+]CCN1.CC(C)CCO.CCOC(C)=O.O=C([O-])c1cnc(N2CCNCC2)c(Cl)c1>>CC(C)CCOC(=O)c1cnc(N2CCNCC2)c(Cl)c1.CO.[NH4+].[OH-],,CCOC(C)=O,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20130156756A1,C1COCCN1.O=C(O)c1ccc(Br)c(O)c1>>O=C(c1ccc(Br)c(O)c1)N1CCOCC1,,C1CCOC1,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04812512,CN(C)C=O.c1ccncc1>>CN(C)c1ccccn1,CCN(CC)CC,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100292233A1,N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4c(c3)cc3n4CCC3CC(=O)O)no2)c1.[N-]=[N+]=[N-]>>O=C(O)CC1CCn2c1cc1cc(-c3noc(-c4cc(OC(F)(F)F)cc(-c5nnn[nH]5)c4)n3)ccc12,,CN(C)C=O,,[Cl-].[NH4+],,val
US08471005B2,C1CC(N2CCOCC2)CCN1.O=[N+]([O-])c1cccc(F)c1>>O=[N+]([O-])c1cccc(N2CCC(N3CCOCC3)CC2)c1,,CCOC(C)=O,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US20110071195A1,CC(=C1C(=O)Nc2ccccc21)c1ccccc1.COC(=O)CBr>>COC(=O)CN1C(=O)C(=C(C)c2ccccc2)c2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050054700A1,Br[Mg]c1ccccc1.CC12CCC3(CC1=CCCC2C=O)SCCS3>>CC12CCC3(CC1=CCCC2C(O)c1ccccc1)SCCS3,,C1CCOC1,,,,val
US20050090524A1,Cc1ccc2nc(Cl)ccc2c1NC(=O)CC12CC3CC(CC(C3)C1)C2.NCCCO>>Cc1ccc2nc(NCCCO)ccc2c1NC(=O)CC12CC3CC(CC(C3)C1)C2,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20100168103A1,c1ccc(CN2CCC(CN3CCCCC3)(c3ccccc3)CC2)cc1>>c1ccc(C2(CN3CCCCC3)CCNCC2)cc1,[Pd],CO,,,,val
US20160237090A1,COCC1CCCN1c1cnn2c1CN(C(=O)OC(C)(C)C)CC2>>COCC1CCCN1c1cnn2c1CNCC2,,CCOC(C)=O,Cl,,,val
US20090318696A1,CN1CCN(c2ccccc2)CC1>>CN1CCN(C2CCCCC2)CC1,[Ru],CCO,,,,val
US20140045872A1,Ic1cnccc1C1CC1.O=C1NCCc2ccc(Cl)cc21>>O=C1c2cc(Cl)ccc2CCN1c1cnccc1C1CC1,I[Cu]I,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20100087667A1,CSc1ccc(O)cc1.O=C(Cl)OCCCl>>Cc1ccc(SC(=O)OCCCl)cc1,,ClCCl,,c1ccncc1,,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccc(OC)c(OC)c4)nc(Cl)c3n2)cc1.NC(=O)c1ccccc1N>>COc1ccc(-c2nc(Nc3ccccc3C(N)=O)c3[nH]ncc3n2)cc1OC,C1COCCO1,CO,,Cl,,val
US20030225053A1,COc1c(NC(=O)c2cc3cccc(N)c3n2C)cc(C(C)(C)C)cc1NS(C)(=O)=O.O=C(Cl)N1CCOCC1>>COc1c(NC(=O)c2cc3cccc(NC(=O)N4CCOCC4)c3n2C)cc(C(C)(C)C)cc1NS(C)(=O)=O,,CCN(CC)CC,,CCN(C(C)C)C(C)C,,val
US20150274767A1,CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](c2cnn3c(N)ncnc23)O[C@@H]1CO>>CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](c2cnn3c(N)ncnc23)O[C@@H]1C=O,,CC#N,,,,val
US20060211720A1,CCOc1cc(/C=N/c2ccc(C#N)cc2)c(F)c(OC(C)C)c1.c1ccc(COCn2cnc3ccccc32)cc1>>CCOc1cc(CN(c2ccc(C#N)cc2)c2nc3ccccc3n2COCc2ccccc2)c(F)c(OC(C)C)c1,,C1CCOC1,,[Li]CCCC,,val
US03979430,Cc1cccc(C=Cc2ccccc2C(=O)O)c1.Cc1cccc(CCc2ccccc2C(=O)O)c1>>O=C(O)c1ccccc1CCCCc1ccccc1,[Pd],CN(C)C=O,,,,val
US20050059607A1,CC(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CCCNC=NN)C(=O)c1nc2ccccc2s1.O=[N+]([O-])O>>CC(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CCCNC=NN)C(=O)c1nc2ccccc2s1.O=[N+]([O-])O,,CC#N,CCO,,,val
US20070124152A1,CC(N)CO.CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN2C(=O)c3ccccc3C2=O)c1=O>>CC(CO)NC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN2C(=O)c3ccccc3C2=O)c1=O,,CCO,,,,val
US20090181942A1,CCOC(=O)C[C@H]1S[C@H](c2cccc(OC)c2CC)c2cc(Cl)ccc2NC1=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)C[C@H]1S[C@H](c2cccc(OC)c2CC)c2cc(Cl)ccc2NC1=S,,Cc1ccccc1,,,,val
US20070208054A1,O=C(O)CBr.OCc1ccc(Br)cc1>>O=C(O)COCc1ccc(Br)cc1,,C1CCOC1,O,CO,[H-].[Na+],val
US20080004271A1,CCOC(=O)c1cc2c(c(OCc3ccccc3)c1)CCO2>>OCc1cc2c(c(OCc3ccccc3)c1)CCO2,,C1CCOC1,,[H-].[Na+],,val
US20030139418A1,BrCc1ccccc1Oc1ccccc1.CCN>>CCNCc1ccccc1Oc1ccccc1,,C1CCOC1,O,,,val
US05665718,C=CCBr.CCN(C(C)C)C(C)C.ClCCl.NCc1noc(-c2ncn3c2[C@@H]2CCN2C(=O)c2ccccc2-3)n1>>C=CCN(CC=C)Cc1noc(-c2ncn3c2[C@@H]2CCN2C(=O)c2ccccc2-3)n1,,ClCCl,,,,val
US20010051740A1,CCCCO.CCCCOC(=O)NC(N)=O>>CCCCOC(=O)OCCCC,,CCCCO,,,,val
US20100063038A1,CC(C)(C)OC(=O)N1CCOC(CNC(=O)c2ccc3c(N)ncnn23)C1.CC1(C)C(=O)N(Br)C(=O)N1Br>>CC(C)(C)OC(=O)N1CCOC(CNC(=O)c2cc(Br)c3c(N)ncnn23)C1,,C1CCOC1,,,,val
US20140018533A1,CCOC(=O)C1=C(Nc2ccc(OCCOC)cc2F)OCC1=O.O=Cc1c[nH]c2ncccc12>>CCOC(=O)C1=C(Nc2ccc(OCCOC)cc2F)OC(=Cc2c[nH]c3ncccc23)C1=O,,CCO,Cl,[Na+].[OH-],,val
US20060211720A1,CCOc1cc(OC(C)C)c(F)c(C(O)c2nc(-c3ccccc3)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1.CS(=O)(=O)Cl>>CCOc1cc(OC(C)C)c(F)c(C(Cl)c2nc(-c3ccccc3)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,,,val
US20100144770A1,CC(C)COc1ccccc1-c1cc(-c2ccc(F)c(C#N)c2)cc(=O)[nH]1.NN>>CCCOc1ccccc1-c1cc(-c2ccc3[nH]nc(N)c3c2)cc(=O)[nH]1,,CCO,,O,,val
US06140354,COc1ccc2c(c1)CC[C@@H](O)[C@@H]2c1ccccc1.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1ccc2c(c1)CC[C@@H](OS(=O)(=O)c1ccc(C)cc1)[C@@H]2c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140088104A1,CCOC(=O)c1c(C)nc2ccc(N)cc2c1-c1ccccc1.O=C1Cc2ccccc2C1>>CCOC(=O)c1c(C)nc2ccc(NC3Cc4ccccc4C3)cc2c1-c1ccccc1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20050043336A1,O=[N+]([O-])c1ccc2c(c1)c(Cl)cn2Cc1ccccn1>>Nc1ccc2c(c1)c(Cl)cn2Cc1ccccn1,,CCO,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US05270313,O=S(=O)(Nc1ncnc(Cl)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1.OCCO>>O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1,,CCOC(C)=O,,Cl,,val
US20070287711A1,COc1ccccc1-c1nn(COCC[Si](C)(C)C)c2ncc(-c3cccc(CC(=O)N(C)C)c3)cc12>>COc1ccccc1-c1n[nH]c2ncc(-c3cccc(CC(=O)N(C)C)c3)cc12,,CS(C)=O,,O=C(O)C(F)(F)F,,val
US20160145251A1,C=C1CC(C(=O)Nc2ccc(Cl)cc2)CN(C(=O)OC(C)(C)C)C1.O=C(O)C(F)(F)F>>C=C1CNCC(C(=O)Nc2ccc(Cl)cc2)C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20080103129A1,COc1ccc(-c2ccc(S(=O)(=O)C3CCCCN(OC(c4ccccc4)(c4ccccc4)c4ccccc4)C3=O)cc2)cc1>>COc1ccc(-c2ccc(S(=O)(=O)C3CCCCN(O)C3=O)cc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120142717A1,CI.O=c1nc(OCCc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)[nH]cc1Cc1cncnc1>>Cn1cc(Cc2cncnc2)c(=O)nc1OCCc1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)c(F)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06610692B1,CCOC(=O)Cn1ccnc(N[C@@H]2COC[C@H]2OCC2CC2)c1=O.O=C1CCC(=O)N1Cl>>CCOC(=O)Cn1c(Cl)cnc(N[C@@H]2COC[C@H]2OCC2CC2)c1=O,,ClC(Cl)Cl,,,,val
US20100041638A1,C1COCCN1.O=Cc1cc(O)ccc1Br>>Oc1ccc(Br)c(CN2CCOCC2)c1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110053912A1,Nc1cnc(Nc2cccc(Cl)c2)nc1C(F)(F)F.O=C(Cl)CC1CCOCC1>>O=C(CC1CCOCC1)Nc1cnc(Nc2cccc(Cl)c2)nc1C(F)(F)F,,ClCCl,,CCOC(C)=O,c1ccncc1,val
US05360802,CC(C)S(=O)(=O)NC(=O)c1cccc(N)c1.CN1C(=O)C(NC(=O)Oc2ccc([N+](=O)[O-])cc2)N=C(C2CCCCC2)c2ccccc21>>CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)NC2(C3CCCCC3)N=Cc3ccccc3N(C)C2=O)c1,,CN(C)C=O,,CCN(CC)CC,,val
US20140243336A1,NN.O=C(CCCCl)C(Br)CBr>>ClCCCc1cc[nH]n1,,CC(C)O,,O,,val
US20020132365A1,CC(C)(C)C(O)C(C)(C)CO.COc1cccc(CCl)c1>>COc1cccc(COCC(C)(C)C(O)C(C)(C)C)c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20110183953A1,CC(C)Oc1ccc(-c2nnc(-c3cccc4c3CC[C@@H]4N)s2)cc1C#N.COC(=O)Cl>>COC(=O)N[C@H]1CCc2c(-c3nnc(-c4ccc(OC(C)C)c(C#N)c4)s3)cccc21,,ClCCl,,Cl,,val
US20090023720A1,NCc1ccccc1.O=[N+]([O-])c1cnc2cc(Br)ccc2c1Cl>>O=[N+]([O-])c1cnc2cc(Br)ccc2c1NCc1ccccc1,,CN(C)C=O,,CCN(CC)CC,O,val
US20100286130A1,CCOc1nc(=O)c2cc(C(F)(F)F)cc([N+](=O)[O-])c2s1.NCc1ccccc1>>O=c1nc(NCc2ccccc2)sc2c([N+](=O)[O-])cc(C(F)(F)F)cc12,,CC(=O)O,,,,val
US20120225854A1,CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)[C@@H](C(=O)O)C1.C[C@H]1COCCN1>>C[C@H]1COCCN1C(=O)[C@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04863958,CCCc1cc(CN(C)C)c2oc(Cc3ccc(OC)cc3)c(C)c2c1O>>CCCc1cc(C)c2oc(Cc3ccc(OC)cc3)c(C)c2c1O,,CCO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20020013302A1,C[C@H](CCC(=O)N(C)C)[C@H]1CC=C2C3=C(CC[C@@]21C)[C@@]1(C)CC[C@H](O[Si](C)(C)C(C)(C)C)C(C)(C)[C@@H]1CC3>>C[C@H](CCC(=O)N(C)C)[C@H]1CC=C2C3=C(CC[C@@]21C)[C@@]1(C)CC[C@H](O)C(C)(C)[C@@H]1CC3,,CCO,,Cl,,val
US20140235628A1,CC(C)(C)OC(=O)C[Zn]Cl.O=C1OCc2cc(Br)ccc21>>CC(C)(C)OC(=O)Cc1ccc2c(c1)COC2=O,,C1CCOC1,,,,val
US20040138286A1,N#Cc1c(OC2CCCCO2)ccc2c1cnn2C1CCCCO1>>N#Cc1c(O)ccc2[nH]ncc12,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20050187390A1,CCOC(=O)c1ccc2c(c1)nc(-c1ccc3nc(C(=O)O)ccc3c1)n2C1CCCCC1>>O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(C(=O)O)ccc3c1)n2C1CCCCC1,,CO,,[Na+].[OH-],,val
US20150376169A1,CN.Cc1ccc(Br)cc1F>>CNc1ccc(C)c(F)c1,[Cu]I,CN(C)C=O,,CC(=O)[O-].[K+],,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(Oc3ccccn3)cc(C)c21>>Cc1cc(Oc2ccccn2)cc2c1C(CC(=O)O)OB2O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20080200471A1,CCc1nn(Cc2ccc(OC)cc2)c2cc(N3CCNCC3)ccc12>>CCc1n[nH]c2cc(N3CCNCC3)ccc12,,O,O=C(O)C(F)(F)F,CO,ClCCl,val
US20130296338A1,Cc1c(F)ccc2cc(C=O)c(Cl)nc12.Cc1cncc(B(O)O)c1>>Cc1cncc(-c2nc3c(C)c(F)ccc3cc2C=O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090093483A1,CCOC(=O)C1=C(O)c2cc(Cl)ccc2C2(CCOCC2)C1=O.COC(=O)CN>>COC(=O)CNC(=O)C1=C(O)c2cc(Cl)ccc2C2(CCOCC2)C1=O,,C1COCCO1,,CCN(C(C)C)C(C)C,Cl,val
US20040209921A1,COC(C)(C)c1cccnc1CN(Cc1ncc(C)cc1C)C1CCNCC1.O=C(NO)Oc1ccccc1>>COC(C)(C)c1cccnc1CN(Cc1ncc(C)cc1C)C1CCN(C(=O)NO)CC1,,C1CCOC1,,,,val
US20050014822A1,COc1ccc([N+](=O)[O-])cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl>>COc1ccc(N)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl,,CCOC(C)=O,,[Na+].[OH-],,val
US05587389,Cc1c(SCc2ccco2)ccnc1CCl.Cl.FC(F)(F)c1ccc2[nH]c(S)nc2c1>>Cc1c(SCc2ccco2)ccnc1CSc1nc2cc(C(F)(F)F)ccc2[nH]1.Cl.Cl,,CC(C)O,,,,val
US20120095016A1,O=C(O)c1[nH]cc2c3nn(-c4ccccc4)c(=O)c-3c[nH]c12>>O=c1c2c[nH]c3c[nH]cc3c-2nn1-c1ccccc1,,CN(C)C=O,,,,val
US20030162798A1,CC(C)Cn1c(=O)n(C)c(=O)c2c(C#CCCCO)n(Cc3cccc4ccccc34)cc21>>CC(C)Cn1c(=O)n(C)c(=O)c2c(CCCCCO)n(Cc3cccc4ccccc34)cc21,[Pd],CCO,,[H][H],,val
US20140274689A1,C=[N+]=[N-].O=C(Cl)c1ccco1>>[N-]=[N+]=CC(=O)c1ccco1,,CCOCC,,,,val
US20050009799A1,CC1(C=O)CCC(c2ccc(OCc3ccccc3)cc2)=C(c2ccc(OCc3ccccc3)cc2)C1>>CC1(CO)CCC(c2ccc(OCc3ccccc3)cc2)=C(c2ccc(OCc3ccccc3)cc2)C1,,CO,,[BH4-].[Na+],,val
US20060128633A1,COc1cc2c(c(OC)c1OC)-c1ccc(C(=O)O)cc1[C@@H](NC(C)=O)CC2.NCCCN1CCOCC1>>COc1cc2c(c(OC)c1OC)-c1ccc(C(=O)NCCCN3CCOCC3)cc1[C@@H](NC(C)=O)CC2,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150225412A1,C=CC(=O)Cl.C[C@H](N(Cc1ccc2c(c1)nc(NC(=O)c1ccc(Cl)cc1)n2C1CCNCC1)C(=O)C(F)(F)F)C(C)(C)C>>C=CC(=O)N1CCC(n2c(NC(=O)c3ccc(Cl)cc3)nc3cc(CN(C(=O)C(F)(F)F)[C@@H](C)C(C)(C)C)ccc32)CC1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20150018341A1,COc1ccc(C(=O)c2ccc(OCCCl)cc2)cc1F>>O=C(c1ccc(OCCCl)cc1)c1ccc(O)c(F)c1,,Br,,O=C([O-])[O-].[Na+].[Na+],,val
US20090054425A1,CC(=O)N1CCN(c2ccc(N)cc2)CC1.Cc1ccc(S(=O)(=O)n2ccc3c(Nc4ccc5c(C)n[nH]c5c4)nc(Cl)nc32)cc1>>CC(=O)N1CCN(c2ccc(Nc3nc(Nc4ccc5c(C)n[nH]c5c4)c4ccn(S(=O)(=O)c5ccc(C)cc5)c4n3)cc2)CC1,,CCCCO,,C[Si](C)(C)Cl,,val
US20030087920A1,CC(=N)N.COC(=O)C(Oc1ccccc1OC)C(=O)OC>>COc1ccccc1Oc1c(O)nc(C)nc1O,,CO,,Cl,C[O-].[Na+],val
US20140256734A1,CC(C)(C)OC(=O)N1CC[C@@H](Oc2nc(-c3n[nH]c(=O)[nH]3)cc3ccccc23)C1>>O=c1[nH]nc(-c2cc3ccccc3c(O[C@@H]3CCNC3)n2)[nH]1,,CN1CCCC1=O,,O=C(O)C(F)(F)F,,val
US20100184750A1,CCOC(=O)C(Br)C(C)C.NCCN>>CC(C)C1NCCNC1=O,,CCO,,C,C[O-].[Na+],val
US20150133424A1,CCOC(=O)C1(NC(=O)c2cccc([N+](=O)[O-])c2)CC1>>O=C(NC1(C(=O)O)CC1)c1cccc([N+](=O)[O-])c1,,CCO,O,Cl,[Na+].[OH-],val
US05488140,C=C(CCOCc1ccccc1)C(O)C(NC=O)C(=O)OCC.O=S(Br)Br>>CCOC(=O)C(C=C(CBr)CCOCc1ccccc1)NC=O,,ClCCl,,O,,val
US20020091148A1,CO.O=C(O)c1[nH]c2ccccc2c1S(=O)(=O)c1ccccc1>>COC(=O)c1[nH]c2ccccc2c1Sc1ccccc1,,c1ccccc1,,C[Si](C)(C)C=[N+]=[N-],,val
US20100063025A1,CCOC(=O)CN1CCC(Oc2cc3cc[nH]c(=O)c3cc2Cl)CC1>>O=C(O)CN1CCC(Oc2cc3cc[nH]c(=O)c3cc2Cl)CC1,,CO,,[Na+].[OH-],,val
US20160159808A1,CCOC(=O)C(C(=O)OC(C)(C)C)c1ncccc1[N+](=O)[O-]>>CCOC(=O)Cc1ncccc1[N+](=O)[O-],,ClCCl,,O=C(O)C(F)(F)F,,val
US20040225111A1,COC(=O)CCc1ccc(C(=O)NC[C@H](Nc2nc3ccc(Br)cc3s2)C(=O)OC(C)(C)C)cc1.NC1=NCCCN1>>CC(C)(C)OC(=O)[C@H](CNC(=O)c1ccc(CCC(=O)NC2=NCCCN2)cc1)Nc1nc2ccc(Br)cc2s1,,C1CCOC1,,,,val
US20100056577A1,Cc1ccc(S(=O)(=O)n2cc(CN(C)C(=O)OC(C)(C)C)c(F)c2-c2cccnc2F)cn1>>CNCc1cn(S(=O)(=O)c2ccc(C)nc2)c(-c2cccnc2F)c1F,,CC(C)O,CCOC(C)=O,Cl,,val
US20080027041A1,Cc1n[nH]c(=O)cc1-c1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1.Cl>>Cc1n[nH]c(=O)cc1-c1ccc(OC2CCNCC2)cc1.Cl,,C1COCCO1,O,,,val
US20080214580A1,Nc1nc(Cl)c(N)c(N[C@@H]2CCOc3c(F)cccc32)n1.O=C(Cl)Cl>>Nc1nc(Cl)c2[nH]c(=O)n([C@@H]3CCOc4c(F)cccc43)c2n1,,C1CCOC1,Cc1ccccc1,,,val
US20150274733A1,COC(=O)C1CC(O[Si](C)(C)C(C)(C)C)CN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CC(O[Si](C)(C)C(C)(C)C)CC1CO,,C1CCOC1,,[BH4-].[Li+],,val
US20030144280A1,CCC[Mg]Br.CON(C)C(=O)c1ccc(Br)c(F)c1>>CCCC(=O)c1ccc(Br)c(F)c1,,C1CCOC1,,,,val
US20120208815A1,CC(C)(C)OC(=O)N1CCN(c2ccc(C(F)(F)F)cc2[N+](=O)[O-])CC1>>CC(C)(C)OC(=O)N1CCN(c2ccc(C(F)(F)F)cc2N)CC1,,CO,,,,val
US20110263647A1,CC(C)(C)OC(=O)NC(CCc1ncc(Br)s1)Cc1ccc(C(F)(F)F)cc1.CC(C)(C)OC(=O)N[C@@H](Cc1ccc(C(F)(F)F)nc1)CN(C(=O)OC(C)(C)C)c1ncc(-c2ccc3cnc(F)cc3c2)s1>>CC(C)(C)OC(=O)NC(CCc1ncc(-c2ccc3cnc(F)cc3c2)s1)Cc1ccc(C(F)(F)F)cc1,,CC#N,O,CC(=O)[O-].[K+],,val
US20140066432A1,CCOC(=O)C1=Cc2cc(Br)ccc2N=C(N)C1.COc1cccc(B(O)O)c1>>CCOC(=O)C1=Cc2cc(-c3cccc(OC)c3)ccc2N=C(N)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[Cs+].[Cs+],val
US05308854,CC(C)(C)S.CCc1cc(C#N)c(Cl)nc1C>>CCc1cnc(SC(C)(C)C)c(C#N)c1,,CN(C)C=O,,O,[H-].[Na+],val
US05834506,Cc1ccc(S(=O)(=O)Sc2cc(C)c(CO)cc2C(C)(C)C)cc1.O=C1C=C(O)CC(CCc2ccc(O)cc2)(c2ccccc2)O1>>Cc1cc(SC2=C(O)CC(CCc3ccc(O)cc3)(c3ccccc3)OC2=O)c(C(C)(C)C)cc1CO,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US05332734,CCOC(=O)COC1c2ccccc2-c2ccccc21>>O=C(O)COC1c2ccccc2-c2ccccc21,,CCO,,[Na+].[OH-],,val
US20090093524A1,CCOC(=O)c1c(C(C)C)nnn1-c1c(Cl)cccc1Cl>>CC(C)c1nnn(-c2c(Cl)cccc2Cl)c1CO,,C1CCOC1,Cc1ccccc1,CC(C)C[AlH]CC(C)C,,val
US20110312936A1,CC(C)(C)OC(=O)NC(CO)C1CCC2(CC1)OCCO2>>O=C1NC(C2CCC3(CC2)OCCO3)CO1,,CCOC(C)=O,,C1CCOC1,CC(C)(C)[O-].[K+],val
US20110110919A1,COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)OCc1ccccc1>>O=C(N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)OCc1ccccc1,,CC(C)(C)O,,O,,val
US20100168113A1,COc1cc(-c2cnnc(-c3cccnc3C(F)(F)F)n2)cc([N+](=O)[O-])c1OC>>O=[N+]([O-])c1cc(-c2cnnc(-c3cccnc3C(F)(F)F)n2)cc(O)c1O,,ClCCl,,BrB(Br)Br,,val
US04563306,COC(=O)[C@@H]1Cc2ccccc2C(=O)N1C>>CN1C(=O)c2ccccc2C[C@H]1C(=O)O,,CO,,Cl,[Na+].[OH-],val
US20120277224A1,CCOC(=O)CC(=O)c1ccc(C(F)(F)F)cc1.Nc1n[nH]c(N)c1-c1ccccn1>>Nc1nn2c(=O)cc(-c3ccc(C(F)(F)F)cc3)[nH]c2c1-c1ccccn1,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080167309A1,CC(C)(C)OC(=O)N1CCC(N)CC1.COc1ccc(CN(C(=O)c2c(F)cccc2F)c2scnc2C(=O)O)cc1>>COc1ccc(CN(C(=O)c2c(F)cccc2F)c2scnc2C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)cc1,,CCOC(C)=O,ClCCl,ClCCCl,On1nnc2ccccc21,val
US20080293712A1,CNC.COCCOc1cc2ncc3c(N)nc(Cl)cc3c2cc1OC>>COCCOc1cc2ncc3c(N)nc(N(C)C)cc3c2cc1OC,,C1CCOC1,O,,,val
US20040110775A1,Fc1nc(OCC2CCCCC2)c2[nH]cnc2n1.Nc1ccccc1>>c1ccc(Nc2nc(OCC3CCCCC3)c3[nH]cnc3n2)cc1,,CCCCO,,,,val
US04874775,CS(=O)(=O)Cl.Clc1ccc(CCNCc2ccncc2)cc1>>CS(=O)(=O)N(CCc1ccc(Cl)cc1)Cc1ccncc1,,O,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US04136256,CCCCCCCCCCCCCCCCNc1ccc(C(=O)Cl)cc1.NS(=O)(=O)C(F)(F)F>>CCCCCCCCCCCCCCCCNc1ccc(C(=O)NS(=O)(=O)C(F)(F)F)cc1,,ClCCl,,Cl,c1ccncc1,val
US20140179664A1,COC(=O)CCl.O=[N+]([O-])c1cn[nH]c1>>COC(=O)Cn1cc([N+](=O)[O-])cn1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110039852A1,CCOC(=O)Cc1ccc(OC)c(B2OC(C)(C)C(C)(C)O2)c1.N#Cc1cc(C(F)(F)F)ccc1Br>>CCOC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2C#N)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20080214613A1,CCOc1ccc(CC(=O)Nc2cc([N+](=O)[O-])ccc2NC2CCN(C)CC2)cc1>>CCOc1ccc(Cc2nc3cc([N+](=O)[O-])ccc3n2C2CCN(C)CC2)cc1,,ClC(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20150299190A1,Nc1ccc(Cl)c(NC(=O)c2cccnc2)c1.O=C(O)c1ccc(N2CCOCS2(=O)=O)cc1Cl>>O=C(Nc1cc(NC(=O)c2ccc(N3CCCS3(=O)=O)cc2Cl)ccc1Cl)c1cccnc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140094473A1,Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(NC(CC[Se]c4ccccc4[N+](=O)[O-])C(C)(C)C)n3)c3cc(F)cnc32)cc1>>C=CC(Nc1nc(-c2cn(S(=O)(=O)c3ccc(C)cc3)c3ncc(F)cc23)ncc1F)C(C)(C)C,,ClC(Cl)Cl,ClCCl,O=C(OO)c1cccc(Cl)c1,,val
US03956374,C=CC(=O)OC.O=C(C=Cc1ccc(Cl)cc1)C(Cc1ccccc1)c1ccccc1>>O=C(O)CCC(Cc1ccccc1)(C(=O)C=Cc1ccc(Cl)cc1)c1ccccc1,,CO,COCCOC,,,val
US20040014802A1,CCOC(=O)/C=C/C(=O)[O-].Nc1n[nH]c2cc(Cl)ccc12>>CCOC(=O)/C=C/C(=O)Nc1n[nH]c2cc(Cl)ccc12,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US05288726,CCC(=Cc1ccccc1F)[N+](=O)[O-]>>CCC(=O)Cc1ccccc1F,[Zn],Cc1ccccc1,,CC(=O)O,,val
US20130225548A1,CC(C)(C)OC(=O)N1CCC(Oc2cncc(Br)c2)CC1.Cl>>Brc1cncc(OC2CCNCC2)c1.Cl,,CCO,,,,val
US20150376181A1,CCOC(=O)c1[nH]c(=O)c(Br)cc1F.N>>NC(=O)c1[nH]c(=O)c(Br)cc1F,,CCO,,,,val
US20040132669A1,CC(C)I.Cc1[nH]nc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(C2CC2)cc1>>Cc1c(Cc2ccc(C3CC3)cc2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1C(C)C,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05215982,CCOC(Cn1ncc(C(=O)O)c1N)OCC>>O=C(O)c1cnn2cc[nH]c12,,O=C(O)C(F)(F)F,,,,val
US20130217668A1,COc1ccc(CCl)cc1.O=[N+]([O-])c1ccc(O)cc1F>>COc1ccc(COc2ccc([N+](=O)[O-])c(F)c2)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20010051620A1,COc1cc2cc3c(=O)c(C#N)c[nH]c3cc2cc1OCc1ccccc1>>COc1cc2cc3c(=O)c(C#N)c[nH]c3cc2cc1O,[Pd],CCOCC,CN(C)C=O,,,val
US20140031354A1,Cc1cn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)cn1>>Cc1cn(-c2ccc(N)cc2C(F)(F)F)cn1,[Pd],CCO,,,,val
US20060084663A1,CCCc1sc(-c2ccc(C(F)(F)F)cc2)nc1CC(=O)OC>>CCCc1sc(-c2ccc(C(F)(F)F)cc2)nc1CCO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070105904A1,Fc1ccc(Br)nc1.N#Cc1ccc(CO)cc1>>N#Cc1ccc(COc2ccc(F)cn2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20030055085A1,COc1ccc(Br)c(C(=O)O)c1.O=C(Cl)C(=O)Cl>>COc1ccc(Br)c(C(=O)Cl)c1,,ClCCl,,CN(C)C=O,,val
US20150197509A1,CC1(C)OB(c2ccc(C(F)(F)F)cc2)OC1(C)C.N#Cc1cc(F)cc(Br)c1>>N#Cc1cc(F)cc(-c2ccc(C(F)(F)F)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070259896A1,CCN.Nc1cccc(OCCCOc2ncnc3scc(-c4ccc(F)cc4)c23)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCNC(=O)Nc1cccc(OCCCOc2ncnc3scc(-c4ccc(F)cc4)c23)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150065499A1,N#Cc1cnc2cc(F)c(F)cc2c1Cl.NC(N)=S>>N#Cc1cnc2cc(F)c(F)cc2c1S,,CCO,,,,val
US20090062268A1,C=O.NC(=O)c1cccc2[nH]c([C@]34CCC[C@H](CN3)C4)nc12>>CN1C[C@H]2CCC[C@]1(c1nc3c(C(N)=O)cccc3[nH]1)C2,,CO,,[BH3-]C#N.[Na+],,val
US07384950B2,CCOC(=O)c1csc2c1c(=O)n(C)c(=O)n2CC(C)C.O=Cc1ccnc2ccccc12>>CCOC(=O)c1c(C(O)c2ccnc3ccccc23)sc2c1c(=O)n(C)c(=O)n2CC(C)C,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20040059101A1,COC(=O)N1C(=O)C=CC1=O.O=[N+]([O-])c1ccc(N(CCCl)CCCl)cc1>>O=C1C=CC(=O)N1c1ccc(N(CCCl)CCCl)cc1,[Pd],CO,,,,val
US20070004753A1,CC(=O)CF.C[Si](C)(C)C#N.Cc1ccc(N)cc1>>Cc1ccc(NC(C)(C#N)CF)cc1,,ClCCl,,,,val
US20140235629A1,CC(C)(C)OC(=O)N[C@H](c1ccc(Cl)cc1Br)[C@H](O)c1cccc(Cl)c1>>N[C@H](c1ccc(Cl)cc1Br)[C@H](O)c1cccc(Cl)c1,,ClCCl,,C1COCCO1,Cl,val
US06355798B1,Clc1nn2c(-c3ccccc3)nnc2cc1C1CCC1.c1nc2n(n1)CCNC2>>c1ccc(-c2nnc3cc(C4CCC4)c(N4CCn5ncnc5C4)nn23)cc1,,CS(C)=O,,,,val
US04233309,COCCn1c(C)ccc1C.O=C(Cl)c1cccnc1>>COCCn1c(C)cc(C(=O)c2cccnc2)c1C,,ClCCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US04281000,CCc1[nH]nc(N)c1C#N.CN(C)C=CC(=O)c1cccnc1>>CCc1nn2c(-c3cccnc3)ccnc2c1C#N,,CC(=O)O,,,,val
US20160122342A1,CCN(c1cccc2c1CC=CC(CO)Cc1cc(C)[nH]c(=O)c1CNC2=O)C1CCOCC1>>CCN(c1cccc2c1CCCC(CO)Cc1cc(C)[nH]c(=O)c1CNC2=O)C1CCOCC1,[Pd],CO,,,,val
US20080004309A1,CCOC(=O)c1ncc2c(c1O)c1ccccc1n2C.O=C1CCC(=O)N1Br>>CCOC(=O)c1nc(Br)c2c(c1O)c1ccccc1n2C,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US05541178,C=CCOC(=O)c1cc(N)ccc1[N+](=O)[O-].CC(=O)Cl>>C=CCOC(=O)c1cc(NC(C)=O)ccc1[N+](=O)[O-],,ClCCl,,CCN(CC)CC,,val
US20090286778A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(N2CCOCC2)c(Br)cc1N>>Cc1cc(N2CCOCC2)c(Br)cc1NC(=O)OC(C)(C)C,,CCO,,,,val
US05462941,NN.O=C(O)c1ccccc1C(=O)c1ccsc1>>O=c1[nH]nc(-c2ccsc2)c2ccccc12,,CCO,,O,,val
US20100291026A1,BrCc1ccccc1.COC(=O)Nc1cnccc1C>>COC(=O)Nc1c[n+](Cc2ccccc2)ccc1C.[Br-],,Cc1ccccc1,,,,val
US08476297B2,C[C@H](N)C(F)(F)F.FC(F)(F)c1ccc([C@H]2NCCc3ccccc32)cc1.O=C(n1ccnc1)n1ccnc1>>C[C@H](NC(=O)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1)C(F)(F)F,,C1CCOC1,,ClCCl,,val
US04608374,O=C=Nc1ccccc1.c1ccc2c(c1)Cn1cccc1C(C1CCNCC1)O2>>O=C(Nc1ccccc1)N1CCC(C2Oc3ccccc3Cn3cccc32)CC1,,c1ccccc1,,,,val
US04709048,CC[C@@]1(CCC(=O)OC)CCCCC1=O>>CC[C@@]1(CCC(=O)O)CCCCC1=O,,CCO,,[Na+].[OH-],,val
US20050032786A1,CS(=O)(=O)c1cccc(Cl)n1.[C-]#N>>N#Cc1cccc(Cl)n1,,O,,CN(C)C=O,,val
US05091378,Fc1ccc(Br)cc1.[Br-].[Mg]>>Fc1ccc([Mg]Br)cc1,,CCOCC,,,,val
US20040023968A1,O=C1OC(=Cc2ccc(F)c([N+](=O)[O-])c2)c2ccccc21>>Nc1cc(C=C2OC(=O)c3ccccc32)ccc1F,[Fe],O,,[Cl-].[NH4+],,val
US20090023710A1,CC(=O)NC(CC(=O)O)c1ccccc1.Nc1ccccc1Oc1ccc(Cl)cc1>>CC(=O)NC(CC(=O)Nc1ccccc1Oc1ccc(Cl)cc1)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,ClCCCl,val
US04929741,C#CCOC(C)OCC.COc1ccc(C=O)c(OC)c1OC>>CCOC(C)OCC#CC(O)c1ccc(OC)c(OC)c1OC,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20110212088A1,CC(C)(C)SCCCCCCCCCCCCCCCCO.CS(=O)(=O)Cl>>CC(C)(C)SCCCCCCCCCCCCCCCCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20160002224A1,CS(=O)(=O)c1ccc(-c2ccc(-c3cc(I)c(N)cc3Cl)cc2)cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CS(=O)(=O)c1ccc(-c2ccc(-c3cc(I)c(NC(=O)C(F)(F)F)cc3Cl)cc2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020128262A1,CNc1ccccc1C(C)=O.O=C(Br)CBr>>CC(=O)c1ccccc1N(C)C(=O)CBr,,ClCCl,,[Na+].[OH-],,val
US20150291562A1,CN(CCCNc1nc(Nc2ccc(OCCOCCOCCOCCN)cc2)ncc1Br)C(=O)C1CCC1.O=C1CCC(N2C(=O)c3cccc(F)c3C2=O)C(=O)N1>>CN(CCCNc1nc(Nc2ccc(OCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)cc2)ncc1Br)C(=O)C1CCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20040176399A1,CCn1c(N)cc(=O)[nH]c1=O.COC(OC)N(C)C>>CCn1c(N=CN(C)C)cc(=O)[nH]c1=O,,CC(=O)N(C)C,,,,val
US20100216814A1,CC1(c2ccncc2)CO1.CN1CCc2[nH]c3c(F)cccc3c2C1>>CN1CCc2c(c3cccc(F)c3n2CC(C)(O)c2ccncc2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20130116249A1,COC(=O)c1cc(C(=O)c2c(C)c(Br)c3ccccn23)ccc1N.COC(=O)c1cccc(B(O)O)c1>>COC(=O)c1cccc(-c2c(C)c(C(=O)c3ccc(N)c(C(=O)OC)c3)n3ccccc23)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20040122098A1,CC(C)(C)OC(=O)N[C@H](CC1CCCCC1)C(O)C(=O)O>>N[C@H](CC1CCCCC1)C(O)C(=O)O,,C1COCCO1,Cl,,,val
US20040106653A1,CCOC(=O)c1ccc(S(=O)(=O)c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1O.[Na+]>>O=C([O-])c1ccc(S(=O)(=O)c2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1O.[Na+],,CO,,Cl,,val
US20080176857A1,CCc1cc2c(N3CCNCC3)nc(SCC(=O)OC)nc2s1.O=C(O)C1COc2ccccc2O1>>CCc1cc2c(N3CCN(C(=O)C4COc5ccccc5O4)CC3)nc(SCC(=O)OC)nc2s1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,Cl,val
US05232898,C#CCN1C(=O)COc2ccc(-n3c(=O)cc(C(F)(F)F)[nH]c3=O)cc21.O=P(Cl)(Cl)Cl>>C#CCN1C(=O)COc2ccc(-n3c(Cl)nc(C(F)(F)F)cc3=O)cc21,,Cc1ccccc1,,c1ccncc1,,val
US05563162,COCCN(Cc1cccnc1)C(=O)OCc1ccccc1>>COCCNCc1cccnc1,[Pd],CCO,,,,val
US20080064719A1,CCC(COC)Oc1cc(C)nc2c(-c3ccc(Br)cc3OC)nn(C)c12.N#Cc1ccc[nH]1>>CCC(COC)Oc1cc(C)nc2c(-c3ccc(-n4cccc4C#N)cc3OC)nn(C)c12,[Cu]I,,,,,val
US20120259123A1,CCCCC(C)(C)c1ccc(CNCc2cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)cc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>CCCCC(C)(C)c1ccc(CNC(c2cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1,,O,,CCN(CC)CC,ClCCl,val
US06495528B1,O[C@@H]1[C@@H](c2nnn(Cc3ccccc3)n2)O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCN4CCCCC4)nc32)[C@@H]1O>>O[C@@H]1[C@@H](c2nn[nH]n2)O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCN4CCCCC4)nc32)[C@@H]1O,[Pd],CCO,,O=C[O-].[NH4+],,val
US20090247618A1,O=COc1cc(Cl)ccc1OCc1ccccc1>>Oc1cc(Cl)ccc1OCc1ccccc1,,CO,,C[O-].[Na+],,val
US05968944,CCOC[C@H]1Cc2ccccc2CN1Cc1c(CC)nn(-c2c(C)cc(Br)cc2C)c1CC.CN(C)C=O>>CCOC[C@H]1Cc2ccccc2CN1Cc1c(CC)nn(-c2c(C)cc(C=O)cc2C)c1CC,,C1CCOC1,,[Li]CCCC,,val
US20100130466A1,CC(=O)CCl.Oc1cnc(F)cc1I>>CC(=O)COc1cnc(F)cc1I,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020132796A1,Cc1cc(Br)ccc1CO.O=C1CCC(=O)N1Br>>Cc1cc(Br)ccc1CBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050119325A1,Cl.Nc1ccc2sc(C(=O)N[C@H]3CN4CCC3CC4)cc2c1.O=C(Cl)c1ccco1>>Cl.O=C(Nc1ccc2sc(C(=O)N[C@H]3CN4CCC3CC4)cc2c1)c1ccco1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20100249149A1,COc1cc(F)ccc1-c1cc(NC(=O)C2CCN(C(=O)OCc3ccccc3)CC2)ncn1>>COc1cc(F)ccc1-c1cc(NC(=O)C2CCNCC2)ncn1,[Pd],CO,,,,val
US20140349993A1,CON(C)C(=O)c1cccc(N)n1>>Nc1cccc(C=O)n1,,C1CCOC1,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US06632826B1,COC1CCC(CC(O)C(Cc2ccccc2)NC(=O)C(CS(=O)c2ccc3ccccc3c2)NS(C)(=O)=O)C(C(=O)NC(C)(C)C)C1.O=C(OO)c1cccc(Cl)c1>>COC1CCC(CC(O)C(Cc2ccccc2)NC(=O)C(CS(=O)(=O)c2ccc3ccccc3c2)NS(C)(=O)=O)C(C(=O)NC(C)(C)C)C1,,ClCCl,,,,val
US05280032,CC(=O)OC[C@@H]1CN(Cc2ccccc2)CCO1>>OC[C@@H]1CN(Cc2ccccc2)CCO1,,CCO,O,[Na+].[OH-],,val
US20080182854A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2cccc(CO)n2)CC1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cccc(CCl)n2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06825181B1,COC(CNS(=O)(=O)c1ccc(C)cc1)OC.COc1cccc(CBr)c1>>COc1cccc(CN(CC(OC)OC)S(=O)(=O)c2ccc(C)cc2)c1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20130115190A1,COc1cnc(Cl)c2cccc(Cl)c12>>Oc1cnc(Cl)c2cccc(Cl)c12,,ClCCl,,BrB(Br)Br,,val
US20090209524A1,CCCCCNc1nc(N)nc(C)c1Cc1ccc(CC(=O)O)cc1F.CO>>CCCCCNc1nc(N)nc(C)c1Cc1ccc(CC(=O)OC)cc1F,,CO,O,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20040106657A1,CCOC(=O)C(Cc1cccc2c1ccn2Cc1nc(-c2cc(OC)cc(OC)c2)oc1C)OCC>>CCOC(Cc1cccc2c1ccn2Cc1nc(-c2cc(OC)cc(OC)c2)oc1C)C(=O)O,,C1COCCO1,,Cl,[Li+].[OH-],val
US20130225579A1,CI.N#Cc1cnc2cc(OC3CCOC3)c(NC(=O)C=C3CCNCC3)cc2c1Nc1ccc(OCc2ccccn2)c(Cl)c1>>CN1CCC(=CC(=O)Nc2cc3c(Nc4ccc(OCc5ccccn5)c(Cl)c4)c(C#N)cnc3cc2OC2CCOC2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060004052A1,CC(C)(C)OC(=O)N[C@@H](C(=O)Nc1cc2c3c(c(-c4ccccc4)[nH]c3c1)C=NNC2=O)C1CCCCC1.O=C(O)C(F)(F)F>>N[C@@H](C(=O)Nc1cc2c3c(c(-c4ccccc4)[nH]c3c1)C=NNC2=O)C1CCCCC1.O=C(O)C(F)(F)F,,CCOCC,CO,ClCCl,,val
US20130096118A1,CC(C)(C)[Si](C)(C)Cl.OC1CCN(c2ccc3cc[nH]c3c2)C1>>CC(C)(C)[Si](C)(C)OC1CCN(c2ccc3cc[nH]c3c2)C1,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US04946857,BrP(Br)Br.C=CC(C)(O)CCCC(C)CCCC(C)C>>CC(=CCBr)CCCC(C)CCCC(C)C,c1ccncc1,CCCCCC,,O,,val
US05932606,CC(C)(C)OC(=O)N[C@@H](C(=O)O)C(c1ccccc1)c1ccccc1.O=C(OCc1ccccc1)[C@@H]1CCCN1>>CC(C)(C)OC(=O)N[C@@H](C(=O)O)C(c1ccccc1)c1ccccc1.O=C(O)[C@@H]1CCCN1,[Pd],CCO,,,,val
US05436359,COc1c(O)c(C)c(CCCCCCCCCCOC(c2ccccc2)(c2ccccc2)c2ccccc2)c(OC(=O)OC(C)(C)C)c1OC.O=C(Cl)c1cccnc1>>COc1c(OC(=O)c2cccnc2)c(C)c(CCCCCCCCCCOC(c2ccccc2)(c2ccccc2)c2ccccc2)c(OC(=O)OC(C)(C)C)c1OC,,ClCCl,,CCN(CC)CC,Cl,val
US20070149525A1,N#Cc1ccccc1C1C=CCO1.N#Cc1ccccc1C1C=COC1>>N#Cc1cccc(C2CCCO2)c1.N#Cc1cccc(C2CCOC2)c1,[Pd],CCOC(C)=O,,,,val
US04059623,CC(=O)C(=NO)C(=O)N(C)C.CON>>CON=C(C)C(=NO)C(=O)N(C)C,,c1ccncc1,,CCO,Cl,val
US20080269218A1,COCOc1cc(OCOC)c(C(C)C)cc1-c1nnc(S(C)(=O)=O)n1-c1ccc(CN2CCN(C)CC2)cc1>>COCOc1cc(OCOC)c(C(C)C)cc1-c1n[nH]c(=O)n1-c1ccc(CN2CCN(C)CC2)cc1,,CS(C)=O,,[Na+].[OH-],,val
US20050192325A1,COC(=O)/C=C/c1ccc(NC(=O)OCc2ccccc2)cc1>>O=C(Nc1ccc(/C=C/CO)cc1)OCc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04956359,C1CNC1.O=C(Cl)N1CC(Oc2cccc(C(F)(F)F)c2)C1>>O=C(N1CCC1)N1CC(Oc2cccc(C(F)(F)F)c2)C1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20030149107A1,CC(C)(C)OC(=O)CCC(=O)c1ccc(OCc2ccccc2F)cc1>>O=C(O)CCC(=O)c1ccc(OCc2ccccc2F)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070219235A1,CCNCC.Nc1cc(Cl)c(C(=O)Nc2ccc3cn[nH]c3c2)cc1[N+](=O)[O-]>>CCN(CC)c1cc(N)c([N+](=O)[O-])cc1C(=O)Nc1ccc2cn[nH]c2c1,,CN1CCCC1=O,O,,,val
US05013842,CO[C@H]1O[C@H](CN=[N+]=[N-])[C@H](OCc2ccccc2)[C@H]1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CO[C@H]1O[C@H](CN=[N+]=[N-])[C@H](OCc2ccccc2)[C@H]1OS(=O)(=O)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US20040220191A1,CC1CCNCC1.N#Cc1ccc(F)cc1>>CC1CCN(c2ccc(C#N)cc2)CC1,,CCOC(C)=O,,,,val
US20040029874A1,CC(C)(C)OC(=O)NC1CCC(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)CC1>>NC1CCC(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)CC1,,O=C(O)C(F)(F)F,,,,val
US20090099227A1,CC(C)(C)OC(=O)N1CCC(S)CC1.O=C(O)c1cc2cnccc2o1>>CC(C)(C)OC(=O)N1CCC(SC(=O)c2cc3cnccc3o2)CC1,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,,val
US07709505B2,COC(=O)c1cc(O)c2cc(C)oc2c1.OCCc1ccsc1>>COC(=O)c1cc(OCCc2ccsc2)c2cc(C)oc2c1,,ClCCl,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160046648A1,NS(=O)(=O)Cl.O=C(Cc1ccccc1O)N1CCC(c2ccccc2C(F)(F)F)CC1>>NS(=O)(=O)Oc1ccccc1CC(=O)N1CCC(c2ccccc2C(F)(F)F)CC1,,C1CCOC1,,[H-].[Na+],,val
US20130303510A1,Cc1ccc(N2CC(C(=O)Nc3ccc(-c4cnn(CC5(C)CCNCC5)c4)cc3)C2)nn1.O=C1COC1>>Cc1ccc(N2CC(C(=O)Nc3ccc(-c4cnn(CC5(C)CCN(C6COC6)CC5)c4)cc3)C2)nn1,,CO,,[BH3-]C#N.[Na+],,val
US05616620,CC(=O)O.CCOc1ccc(CNC(=O)[C@@H](CCCNC(N)=N[N+](=O)[O-])NC(=O)C(c2ccccc2)c2ccccc2)cc1>>CC(=O)[O-].CCOc1ccc(CNC(=O)[C@@H](CCCNC(=N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1,[Pd],ClCCl,,,,val
US20110059999A1,CN(C)C1(c2cccc(F)c2)CCC(C(CN2CCc3c(n(S(=O)(=O)c4ccccc4)c4ccccc34)C2)O[Si](C)(C)C(C)(C)C)CC1>>CN(C)C1(c2cccc(F)c2)CCC(C(O)CN2CCc3c(n(S(=O)(=O)c4ccccc4)c4ccccc34)C2)CC1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20130072519A1,C=O.CCOC(=O)C1c2ccccc2C(=O)N1C>>CCOC(=O)C1(CO)c2ccccc2C(=O)N1C,,C1COCCO1,,C1CCC2=NCCCN2CC1,,val
US20160052884A1,CC(C)(C)OC(=O)c1ccc(N)cc1.COc1cn(C(CC2CCC(O[Si](C)(C)C(C)(C)C)CC2)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N>>COc1cn(C(CC2CCC(O[Si](C)(C)C(C)(C)C)CC2)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N,,CN(C)C=O,,CC(C)N=C=NC(C)C,,val
US20130217671A1,Cl.NC1CCN(c2ncc(Nc3c(C(=O)C4CC4)cnc4ccc(-c5cc(F)c(O)c(Cl)c5)cc34)cn2)C1>>Cl.NC1CCN(c2ncc(Nc3c(C(=O)C4CC4)cnc4ccc(-c5cc(F)c(O)c(Cl)c5)cc34)cn2)C1,,CCOCC,CO,,,val
US20110152233A1,CC(C)(C)OC(=O)N[C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccc(Cl)cc1.CCI>>CCN(C(=O)OC(C)(C)C)[C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccc(Cl)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05837719,O=[N+]([O-])c1ccc(-c2cc(-c3ccncc3)c(-c3ccccc3)[nH]2)cc1>>Nc1ccc(-c2cc(-c3ccncc3)c(-c3ccccc3)[nH]2)cc1,O=[Pt]=O,CCO,CCOC(C)=O,,,val
US20160221945A1,Cl.N#Cc1cc(N2CCC(C(F)(F)F)CC2)c(C(F)(F)F)cn1>>Cl.NCc1cc(N2CCC(C(F)(F)F)CC2)c(C(F)(F)F)cn1,[Pd],CO,,,,val
US20160255837A1,CCSc1nc(C(F)(F)F)ccc1C(=O)O.CNc1nc2c(cc1N)nc(C(F)(F)F)n2C>>CCSc1nc(C(F)(F)F)ccc1C(=O)Nc1cc2nc(C(F)(F)F)n(C)c2nc1NC,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040167121A1,Clc1nc(Cl)c2cc(N3CCCCC3)ccc2n1.Nc1cc(C2CC2)n[nH]1>>Clc1nc(Nc2cc(C3CC3)n[nH]2)c2cc(N3CCCCC3)ccc2n1,,CCO,,,,val
US20150329548A1,C[C@@H]1CC[C@@H](Cn2ccc3nc(Cl)nc(Cl)c32)CC1.OB(O)c1cccc(Cl)c1>>C[C@@H]1CC[C@@H](Cn2ccc3nc(Cl)nc(-c4cccc(Cl)c4)c32)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20080214641A1,C[C@H](N)[C@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccc2c(c1)OCC2.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>C[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccc2c(c1)OCC2,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20070298104A1,CI.COC(=O)c1nc(Br)c2c(Oc3ccccc3)cccc2c1O>>COC(=O)c1nc(Br)c2c(Oc3ccccc3)cccc2c1OC,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160009644A1,BrCCSC(c1ccccc1)c1ccccc1.C1CNCCN1>>c1ccc(C(SCCN2CCNCC2)c2ccccc2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160229814A1,N#Cc1ccc(N)cc1Cl.O=C1CCC(=O)O1>>N#Cc1ccc(NC(=O)CCC(=O)O)cc1Cl,,Cc1ccccc1,,Cl,,val
US20120165550A1,Brc1ccccc1.OB(O)c1cc2ccccc2c2c1oc1ccccc12>>c1ccc(-c2cc3ccccc3c3c2oc2ccccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20090036443A1,CC(C)N=C(NC(C)C)OC(C)(C)C.O=C(O)c1cc2[nH]cc(C3CCCCC3)c2s1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)c1cc2[nH]c(Br)c(C3CCCCC3)c2s1,,C1CCOC1,ClCCl,,,val
US20120101124A1,CCOC(=O)CCc1ccc(-c2noc(-c3cnc(OC(C)C)c(Cl)c3)n2)c2cc[nH]c12>>CC(C)Oc1ncc(-c2nc(-c3ccc(CCC(=O)O)c4[nH]ccc34)no2)cc1Cl,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20030109743A1,CCCC(=O)C(=O)OCC.C[C@H](N)C(=O)O>>CCC[C@H](N[C@@H](C)C(=O)O)C(=O)OCC,[Pd],O,,[Na+].[OH-],,val
US20080009530A1,CCCCCS(N)(=O)=O.COCCOc1ccc(CCC(=O)O)c(Oc2ncc(C(F)(F)F)cc2Cl)c1>>CCCCCS(=O)(=O)NC(=O)CCc1ccc(OCCOC)cc1Oc1ncc(C(F)(F)F)cc1Cl,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20050153971A1,O=C1OC(CO)CN1c1ccc(I)c(F)c1.Oc1ccon1>>O=C1OC(COc2ccon2)CN1c1ccc(I)c(F)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05998436,CC(C)(C)Nc1nc(Cl)c(C#N)cc1F.NCc1ccccc1>>CC(C)(C)Nc1nc(NCc2ccccc2)c(C#N)cc1F,,CN1CCCC1=O,,,,val
US06313344B1,CC(=O)C(=NO)c1ccc(OC[Si](C)(C)c2ccc(F)cc2)cc1.CCBr>>CCON=C(C(C)=O)c1ccc(OC[Si](C)(C)c2ccc(F)cc2)cc1,,CN(C)C=O,,CCOCC,O=C([O-])[O-].[K+].[K+],val
US20050272744A1,BrCc1ccccc1Br.CC(C)(C)OC(=O)N1CCNCC1>>CC(C)(C)OC(=O)N1CCN(Cc2ccccc2Br)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080249071A1,CC(C)(C)c1csc(N)n1.O=C1CCC(=O)N1Br>>CC(C)(C)C1=CSC(N)N1Br,,ClC(Cl)(Cl)Cl,,CCCCCC,,val
US20070232583A1,Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(N)c3)n2)n1.O=S(=O)(Cl)N1CCOCC1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(NS(=O)(=O)N4CCOCC4)c3)n2)n1,,ClCCl,ClCCl,CCN(CC)CC,,val
US20140046074A1,Br.CC[C@@H](c1cccc(OCc2ccccc2)c1)[C@@H](C)CO>>CC[C@@H](c1cccc(OCc2ccccc2)c1)[C@@H](C)CBr,,ClCCl,,O,,val
US20140296245A1,COc1ccc(C=O)c(OC)c1.Nc1ncccn1>>COc1ccc(CNc2ncccn2)c(OC)c1,,CC(=O)O,Cc1ccccc1,[Na+].[OH-],,val
US20110136800A1,Fc1cc(F)c2c(c1)[C@@H]1CCCN[C@H]1CC2.O=C(O)c1ccc2[nH]cnc2c1>>O=C(c1ccc2[nH]cnc2c1)N1CCC[C@H]2c3cc(F)cc(F)c3CC[C@@H]21,,CO,ClCCl,,,val
US20060235031A1,CN1CCN(C2CC(c3nc(I)c4c(Cl)nccn34)C2)CC1.N>>CN1CCN(C2CC(c3nc(I)c4c(N)nccn34)C2)CC1,,CC(C)O,,C1CCOC1,,val
US20130316981A1,CC(C)(C)OC(=O)NC1CCNCC1.NC(=O)c1ccc(NC(=O)CCl)cc1>>CC(C)(C)OC(=O)NC1CCN(CC(=O)Nc2ccc(C(N)=O)cc2)CC1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20020173517A1,Cc1nccc(Cl)c1OC(F)F.O=C(OO)c1cccc(Cl)c1>>Cc1c(OC(F)F)c(Cl)cc[n+]1[O-],,ClCCl,,,,val
US20140080798A1,CC(C)(C)OC(=O)NCc1ccc(Nc2ncc(C(F)(F)F)c(CCc3ccccc3CC(N)=O)n2)cc1>>NCc1ccc(Nc2ncc(C(F)(F)F)c(CCc3ccccc3CC(N)=O)n2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05891871,COC(=O)Cc1ccc2c(c1)OCO2.COc1ccc(C(=O)Cl)cc1>>COC(=O)Cc1cc2c(cc1C(=O)c1ccc(OC)cc1)OCO2,,ClCCl,,Cl[Sn](Cl)(Cl)Cl,,val
US04798893,CC(=O)C1C(=O)OC2(C#Cc3ccccc3)C=CC(=O)CC12>>CC(=O)Cc1cc(O)ccc1C#Cc1ccccc1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20150175623A1,N#Cc1ccccc1F.NO>>NC(=NO)c1ccccc1F,,CO,,Cl,O=C([O-])O.[Na+],val
US20040006123A1,C1CCOC1.CC#N.CCOC(=O)CNc1ccccc1C#N.CCOC(=O)c1[nH]c2ccccc2c1N>>O=C(O)c1[nH]c2ccccc2c1Nc1ccncc1,,C1CCOC1,O,CC(C)(C)[O-].[K+],,val
US20160024110A1,CCOC(=O)C(F)(F)F.CCOC(=O)Cc1ccc(Cl)cc1Cl>>CCOC(=O)C(C(=O)C(F)(F)F)c1ccc(Cl)cc1Cl,,CCOCC,,Cl,[Na],val
US05500424,CCc1cccc(CC)c1N.Cc1ncc(C(=O)O)c(-c2ccccc2Cl)n1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCc1cccc(CC)c1NC(=O)Nc1cnc(C)nc1-c1ccccc1Cl,,O,c1ccccc1,CCN(CC)CC,,val
US20150126513A1,CCOC(=O)C1=C(C)OCCC1.O=[Se]=O>>CCOC(=O)C1=C(C=O)OCCC1,,CC(=O)O,,,,val
US05283361,OCc1c(F)cccc1Sc1ccc(F)cc1>>O=Cc1c(F)cccc1Sc1ccc(F)cc1,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20140163066A1,COC(=O)c1ccc(COc2cccc([C@@H](NC(=O)OC(C)(C)C)c3ccccc3)c2)cc1OC>>COc1cc(COc2cccc([C@@H](NC(=O)OC(C)(C)C)c3ccccc3)c2)ccc1C(=O)O,,C1CCOC1,CO,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US20140155389A1,CCOc1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)ccc1N>>CCOc1cc(C2CCN(C(=O)OC(C)(C)C)CC2)ccc1N,[Pd],CO,,,,val
US20070049643A1,CCON.COc1ccc(CC(C)=O)cc1OC>>CCONC(C)Cc1ccc(OC)c(OC)c1,,O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US06177440B1,COC(=O)c1cccc2c1c1c(n2CC2CCCC2)CCCC1=O>>COC(=O)c1cccc2c1c1c(O)cccc1n2CC1CCCC1,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20100056515A1,CCC(CC)c1ccc(OC)c2nc(Cl)n(C)c12.CN(C)c1cc(Cl)c(O)c(CN2CCCC2)c1>>CCC(CC)c1ccc(OC)c2nc(Oc3c(Cl)cc(N(C)C)cc3CN3CCCC3)n(C)c12,,O=C([O-])O,[Na+],CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US20110130419A1,CCO.Cc1cccc2c(=O)[nH]c(CCN3CCC[C@@H]3CO)cc12.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>Cc1cccc2c(=O)[nH]c(CCN3CCC[C@@H]3CO)cc12.O.O=C(O)[C@H](O)[C@@H](O)C(=O)O,,CCO,,,,val
US05849757,CCOC(=O)C(C(=O)OCC)C1CN(C(=O)OCc2ccccc2)C1>>CCOC(=O)C(C(=O)O)C1CN(C(=O)OCc2ccccc2)C1,,CCO,,[K+].[OH-],,val
US20140155427A1,COC(=O)c1ccc(CBr)cc1.Oc1cccc(CNc2ccccc2)c1>>COC(=O)c1ccc(COc2cccc(CNc3ccccc3)c2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070197500A1,C=O.CCOP(=O)(OCC)C(Cc1cscn1)C(=O)OC(C)(C)C>>C=C(Cc1cscn1)C(=O)OC(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20150353553A1,BrC(Br)(Br)Br.CCC1CCC(CO)C1>>CCC1CCC(CBr)C1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20030089885A1,CC(C)CC(=O)Cl.CCCO>>CCCOC(=O)CC(C)C,,ClCCl,,CCN(CC)CC,,val
US20020040146A1,BrCc1ccccc1.CS(=O)(=O)N1CC(CO)C(CO)C1>>CS(=O)(=O)N1CC(CO)C(COCc2ccccc2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20030060467A1,Cc1ccc(S(=O)(=O)Oc2cc([C@H](C)O)[nH]n2)cc1>>CC(=O)c1cc(OS(=O)(=O)c2ccc(C)cc2)n[nH]1,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20100069431A1,BrCc1ccccc1.COC(=O)c1cc(O)ccc1O>>COC(=O)c1cc(OCc2ccccc2)ccc1O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130225552A1,CC1(C)C(=O)N([C@H]2C[C@H](N)C2)c2ncncc21.Clc1nc2ccccc2s1>>CC1(C)C(=O)N([C@@H]2C[C@@H](Nc3nc4ccccc4s3)C2)c2ncncc21,,CS(C)=O,O,CCN(C(C)C)C(C)C,Cl,val
US20030162764A1,COC(=O)C(=O)Nc1cc(NCCNC(C)=O)nc(-c2ccccc2)n1>>CC(=O)NCCNc1cc(NC(=O)C(=O)O)nc(-c2ccccc2)n1,,C1CCOC1,,,,val
US04719208,BrCc1ccccc1.OCc1cnccc2c3ccccc3nc1-2>>OCC1CN(Cc2ccccc2)CCc2c1[nH]c1ccccc21,,ClC(Cl)Cl,O,CCN(C(C)C)C(C)C,O=C([O-])[O-].[K+].[K+],val
US20160064676A1,NCCN.O=C1C(=O)c2ccc(Br)cc2-c2cc(Br)ccc21>>Brc1ccc2c(c1)c1cc(Br)ccc1c1nccnc21,,CC(=O)O,,CCO,,val
US20100075948A1,CC(C)(C)C[C@@H]1N[C@@H](C(=O)O)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F.COC(=O)Cc1ccc(N)cc1>>COC(=O)Cc1ccc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(c3ccc(Cl)cc3F)[C@H]2c2cccc(Cl)c2F)cc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060276464A1,CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccc(F)cc3)ccc2C(F)(F)F)CC1.CN>>CNc1ccc(S(=O)(=O)c2ccc(C(F)(F)F)c(S(=O)(=O)NC3CCN(C(=O)OC(C)(C)C)CC3)c2)cc1,,CCO,,,,val
US05051361,Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)n(CCN)c1=O.O=C(O)CCc1ccc(O)cc1>>Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)n(CCNC(=O)CCc2ccc(O)cc2)c1=O,,CO,,CCN(CC)CC,,val
US20050215556A1,C=CCBr.Cc1cc(Br)c(O)c([N+](=O)[O-])c1>>C=CCOc1c(Br)cc(C)cc1[N+](=O)[O-],,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100179149A1,BrCc1ccc2nsnc2c1.O=c1ccc(-c2cc(F)c(F)c(F)c2)n[nH]1>>O=c1ccc(-c2cc(F)c(F)c(F)c2)nn1Cc1ccc2nsnc2c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20080214545A1,CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccncc3)cc2)n(-c2ccc(N)cc2)n1.CC1(C)CC(=O)OC1=O>>CC(C)(CC(=O)Nc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccncc3)cc2)cc1)C(=O)O,,C1CCOC1,CCOCC,,,val
US20140275030A1,Cn1nccc1B1OC(C)(C)C(C)(C)O1.O=C1CCC(=O)N1Cl>>Cn1ncc(Cl)c1B1OC(C)(C)C(C)(C)O1,,C1CCOC1,,,,val
US20110118230A1,CC(C)(C)OC(=O)N1CCC(O)(c2ccc(Br)cc2)CC1.COCCN(CCOC)S(F)(F)F>>CC(C)(C)OC(=O)N1CCC(F)(c2ccc(Br)cc2)CC1,,ClCCl,,,,val
US20090062294A1,C[Si](C)(C)C#Cc1cccc(CN2CCN(C(=O)Nc3noc4ccccc34)CC2)c1>>C#Cc1cccc(CN2CCN(C(=O)Nc3noc4ccccc34)CC2)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20130217680A1,CCOC(=O)C(C)c1ccc([N+](=O)[O-])nc1C>>CCOC(=O)C(C)c1ccc(N)nc1C,[Pd],CO,,CC(=O)O,,val
US20040044052A1,CN.COC(=O)[C@H]1CN(c2cc(F)c3c(c2)oc(=O)n3C)C(=O)O1>>CNC(=O)[C@H]1CN(c2cc(F)c3c(c2)oc(=O)n3C)C(=O)O1,,CO,,,,val
US20090111983A1,COC(=O)C1(NC(=O)OCc2ccco2)CCCCC1>>O=C(NC1(C(=O)O)CCCCC1)OCc1ccco1,,C1CCOC1,,[Na+].[OH-],,val
US20080004262A1,Cc1cc(C#N)nc2cc3c(cc12)OC(C)(C)[C@H](O)[C@H]3NCCc1ccccc1>>Cc1cc(CN)nc2cc3c(cc12)OC(C)(C)[C@H](O)[C@H]3NCCc1ccccc1,[Pd],CC(=O)O,,,,val
US05965679,C#Cc1ccccc1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=C(C(=O)c1cccc(Br)c1)c1cccc(Br)c1>>O=C(C(=O)c1cccc(C#Cc2ccccc2)c1)c1cccc(C#Cc2ccccc2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCN(CC)CC,,,,val
US20120165305A1,O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.OCC1CC1>>O=C(OCC1CC1)Oc1ccc([N+](=O)[O-])cc1,,ClCCl,,CCN(CC)CC,,val
US20110034452A1,CCN(CC)C(=O)c1cc2nnc(N)n2nc1Cl.CCO>>CCOc1nn2c(N)nnc2cc1C(=O)N(CC)CC,,CCO,,C,C[O-].[Na+],val
US20150315209A1,CO[C@H]1C[C@H](C#N)N(C(=O)OC(C)(C)C)C1>>CO[C@@H]1CN[C@@H](C#N)C1,,CC#N,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20060122064A1,C#CC(C)OS(C)(=O)=O.CCOC(=O)CCc1ccc(O)c(OC)c1>>C#CC(C)Oc1ccc(CCC(=O)OCC)cc1OC,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20110312911A1,CCCC(c1ccc(C(=O)NCCC(=O)OC)cc1)C(CO)c1ccc(Cl)cc1.FC(F)(F)Oc1ccc(CBr)cc1>>CCCC(c1ccc(C(=O)NCCC(=O)OC)cc1)C(COCc1ccc(OC(F)(F)F)cc1)c1ccc(Cl)cc1,,ClCCl,,,,val
US20150175530A1,COC(=O)[C@@H](NC(=O)c1ccc(C#CC#C[C@@H](O)CO)cc1)C(C)(C)NC(=O)OC(C)(C)C>>COC(=O)[C@@H](NC(=O)c1ccc(C#CC#C[C@@H](O)CO)cc1)C(C)(C)N,,CCOCC,CO,Cl,,val
US03951823,CCCCCCCCCCCCCCC=CS(=O)(=O)O>>C=CCCCCCCCCCCCCCC,,CC(C)=O,,,,val
US20160158207A1,Cc1ccc(-c2cc3c(cc2C(F)F)N(c2nn(C4CCOCC4)c4c2CN(C(=O)OC(C)(C)C)CC4)CCC3)s1>>Cc1ccc(-c2cc3c(cc2C(F)F)N(c2nn(C4CCOCC4)c4c2CNCC4)CCC3)s1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06002008,N#Cc1cnc2ccc(N)cc2c1Nc1cccc(Br)c1.O=C(Cl)CCl>>N#Cc1cnc2ccc(NC(=O)CCl)cc2c1Nc1cccc(Br)c1,,C1CCOC1,,CCN(CC)CC,,val
US07268154B2,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](O)CC1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](N=[N+]=[N-])CC1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140256771A1,Cn1nc(C(F)(F)F)cc1-c1ccc(NC(=O)c2c(F)ccc(F)c2F)cc1F>>Cn1nc(C(F)(F)F)cc1-c1ccc(NCc2c(F)ccc(F)c2F)cc1F,,C1CCOC1,,CCOC(C)=O,Cl,val
US06150373,CNc1nc(SC)ncc1CNC1CCCCC1.O=C(Cl)Cl>>CSc1ncc2c(n1)N(C)C(=O)N(C1CCCCC1)C2,,C1CCOC1,,CCN(CC)CC,[Cl-].[NH4+],val
US20130029949A1,BrCc1ccc(Br)cc1.CCNC(C)=O>>CCN(Cc1ccc(Br)cc1)C(C)=O,,C1CCOC1,O,CCOC(C)=O,CC(C)(C)[O-].[K+],val
US20120028974A1,COc1cccn2nc(C3(CN)CC3)nc12.O=C(Cl)N1CCCC1>>COc1cccn2nc(C3(CNC(=O)N4CCCC4)CC3)nc12,,C1CCOC1,O,CCN(CC)CC,O=C([O-])O.[Na+],val
US20070015757A1,COC(=O)c1ccc(C2=NOC(c3ccc(C4CCCCC4)cc3)C2C(=O)c2ccc(C(C)(C)C)cc2)cc1>>COC(=O)c1ccc(-c2noc(-c3ccc(C4CCCCC4)cc3)c2C(=O)c2ccc(C(C)(C)C)cc2)cc1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US08742113B2,COCCNC1=C(C(=O)OC)C(=O)C(=Cc2c[nH]c3ncccc23)O1>>COCCNC1=CC(=O)C(=Cc2c[nH]c3ncccc23)O1,,CCO,,Cl,[K+].[OH-],val
US20130190512A1,CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C.CN(C)C(On1nnc2cccnc21)=[N+](C)C>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)On1nnc2cccnc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04337201,CC(C)(C)C(=O)OCCl.O=C(OCc1ccccc1)[C@@H]1CCCN1C(=O)CP(=O)(O)CCCCc1ccccc1>>CC(C)(C)C(=O)OCOP(=O)(CCCCc1ccccc1)CC(=O)N1CCC[C@H]1C(=O)OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20060217562A1,Cc1ccc(S(=O)(=O)n2nc(C(=O)O)c3c2CC(=O)C3)cc1.O=C1CCC(=O)N1O>>Cc1ccc(S(=O)(=O)n2nc(C(=O)ON3C(=O)CCC3=O)c3c2CC(=O)C3)cc1,,ClCCl,,ClCCCl,,val
US20130190315A1,CC1(C)OCc2c(CCO)cccc2O1.CS(=O)(=O)Cl>>CC1(C)OCc2c(CCOS(C)(=O)=O)cccc2O1,,C1CCOC1,CCOC(C)=O,,,val
US04159273,CCCc1c2ccccc2c(O)c2c(=O)cc(C(=O)[O-])oc12>>CCCc1c2ccccc2c(O)c2c(=O)cc(C(=O)O)oc12,,O,,Cl,,val
US20120270852A1,CC(C)OC(=O)c1ncc(Br)cc1C#N>>N#Cc1cc(Br)cnc1C(=O)O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20110306589A1,CCOC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1C>>Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)O,,CCO,O,Cl,[Na+].[OH-],val
US20130184282A1,CCOC(=O)CCCCCCn1ccc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc21>>CCOC(=O)CCCCCCN1CCc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc21,[Pd],CCO,,O=C[O-].[NH4+],,val
US20120329649A1,Cc1cc(Br)cc(C#N)c1-n1cncn1.Cc1ccccc1>>C=Cc1cc(C)c(-n2cncn2)c(C#N)c1,,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])[O-].[K+].[K+],val
US20150258074A1,Cc1nc(Cl)cc2c1c(OCc1ccccc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1.O=[Se]=O>>O=Cc1nc(Cl)cc2c1c(OCc1ccccc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1,,C1COCCO1,,,,val
US20020091138A1,Clc1ccc(C2(c3ccc4noc(-c5cccc(Cl)c5)c4c3)OCCO2)cc1>>O=C(c1ccc(Cl)cc1)c1ccc2noc(-c3cccc(Cl)c3)c2c1,,CO,Cl,N,,val
US05614633,Cc1cc(C)c(S(=O)(=O)ON)c(C)c1.O=[N+]([O-])c1ccc2c(c1)C(c1ccccn1)=CC(CF)(CF)O2>>Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1.N[n+]1ccccc1C1=CC(CF)(CF)Oc2ccc([N+](=O)[O-])cc21,,CCOCC,,ClCCl,,val
US20150259352A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1cc(S(C)(=O)=O)ccc1-c1cc(Br)ccc1F>>COc1cc(S(C)(=O)=O)ccc1-c1cc(B2OC(C)(C)C(C)(C)O2)ccc1F,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20160108056A1,COc1cc([N+](=O)[O-])cc(S(=O)(=O)c2cccc(OC(F)(F)F)c2)c1>>O=[N+]([O-])c1cc(O)cc(S(=O)(=O)c2cccc(OC(F)(F)F)c2)c1,,ClCCl,,BrB(Br)Br,,val
US05589492,COC(=O)C(Cl)Cc1ccc(OCc2ccccc2)cc1.O=S([O-])c1ccccc1>>COC(=O)C(Cc1ccc(OCc2ccccc2)cc1)S(=O)(=O)c1ccccc1,,O,,CN(C)C=O,,val
US20130150343A1,CC(C)[Si](O[C@H]1CCCN(c2nnc3ccc(O[C@@H]4CC[C@H](N)c5ccccc54)cn23)C1)(C(C)C)C(C)C.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCC[C@H](O[Si](C(C)C)(C(C)C)C(C)C)C5)n4c3)c3ccccc32)cc1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20160102059A1,CC(C)[Si](C#Cc1cc(Nc2cc(Oc3ccc(N)c4ccccc34)ccn2)ccc1C(=O)NCCN1CCOCC1)(C(C)C)C(C)C.COc1c(NC(=O)Oc2ccccc2)cc(C(C)(C)C)cc1NS(C)(=O)=O>>COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(C(=O)NCCN5CCOCC5)c(C#C[Si](C(C)C)(C(C)C)C(C)C)c4)c3)c3ccccc23)cc(C(C)(C)C)cc1NS(C)(=O)=O,,CC(=O)OC(C)C,,CCN(CC)CC,,val
US20080058304A1,CCC(O)c1cc(Br)cc(OC)c1OC.CCN(CC)S(F)(F)F>>CCC(F)c1cc(Br)cc(OC)c1OC,,ClCCl,,,,val
US20130217664A1,CCc1cc(C#N)ccc1N(C)c1cc2c(cn1)ncn2C.O>>CCc1cc(C(N)=O)ccc1N(C)c1cc2c(cn1)ncn2C,,[Na+],[OH-],CO,ClCCl,val
US20090181965A1,BrBr.O=C1CCCCC1c1ccccc1Cl>>O=C1C(Br)CCCC1c1ccccc1Cl,,ClC(Cl)Cl,,,,val
US05013737,NC(=O)c1cnn2c1NCCC2c1cccc(C(F)(F)F)c1.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]c(=O)n2c3c1cnn3C(c1cccc(C(F)(F)F)c1)CC2,,C1CCOC1,,,,val
US04234588,CN(C)Cc1ccc(CSCCN)o1.COc1ccc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)cn1>>COc1ccc(Cc2cnc(NCCSCc3ccc(CN(C)C)o3)[nH]c2=O)cn1,,CCO,,,,val
US20060211689A1,O=C(O)c1cc(N2CCOCC2)ccc1[N+](=O)[O-]>>Nc1ccc(N2CCOCC2)cc1C(=O)O,[Pd],CCO,,C1=CCCCC1,,val
US04855301,COC1=NC(C)=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)N1C(=O)N(C)C>>CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)N(C(=O)N(C)C)C(=O)N1,,C1CCOC1,CO,Cl,,val
US20100273837A1,COc1cc(Cl)ccc1-c1nsc(CBr)n1.NC(=O)c1c(F)ccc(O)c1F>>COc1cc(Cl)ccc1-c1nsc(COc2ccc(F)c(C(N)=O)c2F)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04394156,Cc1cc(C)c([N+](=O)[O-])cc1N.N#CCC(=O)Cl>>Cc1cc(C)c([N+](=O)[O-])cc1NC(=O)CC#N,,C1CCOC1,,CCN(CC)CC,,val
US20030013714A1,NCCCCCCNS(=O)(=O)c1ccccc1[N+](=O)[O-].O=Cc1ccc2ccccc2c1>>O=[N+]([O-])c1ccccc1S(=O)(=O)NCCCCCCNCc1ccc2ccccc2c1,,Cc1ccccc1,,Cl,,val
US05795899,CN(C(=O)C(C#N)=CNC(=N)N1CC(C)(C)NC1=O)c1cccc(C(F)(F)F)c1.Cl>>CN(C(=O)C(C#N)=CNC(=N)N1CC(C)(C)NC1=O)c1cccc(C(F)(F)F)c1.Cl,,CCO,CCOCC,,,val
US04552891,CCOc1cc2cc(C(=O)O)sc2cc1O.CO>>CCOc1cc2cc(C(=O)OC)sc2cc1O,,CCOC(C)=O,ClCCl,O=S(=O)(O)O,,val
US05196431,CC(C)(C)c1nc(NC(N)=S)nc(C(C)(C)C)c1O.CI>>CSC(=N)Nc1nc(C(C)(C)C)c(O)c(C(C)(C)C)n1,,CCO,,,,val
US04963580,Oc1ccc2sccc2c1>>Oc1ccc2c(c1)CCS2,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20060041003A1,CCCCC1(CC(C)=O)CCc2cc(OC)ccc2C1=O>>CCCCC12CCc3cc(OC)ccc3C1=CC(=O)C2,,CCO,O,[K+].[OH-],,val
US20130281434A1,COc1cncc(B2OC(C)(C)C(C)(C)O2)c1.Cc1cc2nc(-c3cccc(OS(=O)(=O)C(F)(F)F)c3)sc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C>>COc1cncc(-c2cccc(-c3nc4cc(C)c([C@@H](CO)OC(C)(C)C)c(-c5ccc(Cl)cc5)c4s3)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CO,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20080070954A1,COc1ccc(CONC(=O)CCCCCN)c(OC)c1.O=C(N=C=S)c1ccccc1>>COc1ccc(CONC(=O)CCCCCNC(=S)NC(=O)c2ccccc2)c(OC)c1,,ClCCl,,CCN(CC)CC,,val
US20090239810A1,CCOC(=O)C(=O)CC(=O)c1ccccc1.NO>>COC(=O)c1cc(-c2ccccc2)on1,,CO,,Cl,,val
US05464867,CCOc1c(Nc2ccc(C#N)cc2)c(=O)c1=O.NCC(F)(F)C(F)(F)F>>N#Cc1ccc(Nc2c(NCC(F)(F)C(F)(F)F)c(=O)c2=O)cc1,,CCO,,,,val
US04205069,C=CCBr.COC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1>>C=CCN[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)OC,,CO,,,,val
US20110065717A1,CC(C)(C)OC(=O)N1CCCC1C(=O)N=S(C)(=O)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)cc1>>CS(=N)(=O)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)cc1,,CO,O,O=S(=O)(O)O,,val
US06043269,COc1ccc2c(c1)OC[C@@H](c1ccccc1)[C@H]2c1ccc(O)cc1.CS(=O)(=O)Cl>>COc1ccc2c(c1)OC[C@@H](c1ccccc1)[C@H]2c1ccc(OS(C)(=O)=O)cc1,,c1ccncc1,,CCOC(C)=O,Cl,val
US20150322002A1,CC(C)Oc1ncc(Oc2cc(F)c(C(=O)OC(C)(C)C)cc2I)cc1Cl.OB(O)C1CC1>>CC(C)Oc1ncc(Oc2cc(F)c(C(=O)OC(C)(C)C)cc2C2CC2)cc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20060004082A1,Cc1cc(C(C)(C)C(=O)N2CCCC2)sc1Br>>Cc1csc(C(C)(C)C(=O)N2CCCC2)c1,[Zn],CC(=O)O,O,,,val
US20020103161A1,CCOP(=O)(OCC)c1ccc(CCC(=O)O)cc1P(=O)(OCC)OCC.Cc1ccc(-c2cn(C3COC(CO)C3)c3ncnc(N)c23)cc1>>CCOP(=O)(OCC)c1ccc(CCC(=O)OCC2CC(n3cc(-c4ccc(C)cc4)c4c(N)ncnc43)CO2)cc1P(=O)(OCC)OCC,CN(C)c1ccncc1,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20160264573A1,CC(C)(C)OC(=O)N1C[C@H](NOCc2ccccc2)CC[C@H]1C(=O)O.O=C1[C@H]2[C@H]3C=C[C@H](C3)[C@H]2C(=O)N1O>>CC(C)(C)OC(=O)N1C[C@H](NOCc2ccccc2)CC[C@H]1C(=O)ON1C(=O)[C@H]2[C@H]3C=C[C@H](C3)[C@H]2C1=O,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCN=C=NCCCN(C)C,Cl,val
US20130059830A1,CC(C)(C)OC(=O)NCC(OCc1ccccc1)C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NCC(OCc1ccccc1)C(=O)O,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20060160864A1,CCCCOCCOc1ccc(-c2cnc(N3CCCC3)c(C=O)c2)cc1.CCOC(=O)C(C)P(=O)(OCC)OCC>>CCCCOCCOc1ccc(-c2cnc(N3CCCC3)c(/C=C(\C)C(=O)OCC)c2)cc1,,Cc1ccccc1,,[H-].[Na+],,val
US20040063761A1,COC(=O)c1ccccc1-c1ccc(CN=[N+]=[N-])nc1>>COC(=O)c1ccccc1-c1ccc(CN)nc1,[Ni],CCO,,,,val
US20150197512A1,CC(C)Oc1cccs1.CN(C)C=O>>CC(C)Oc1ccc(C=O)s1,,C1CCOC1,CN(C)P(=O)(N(C)C)N(C)C,Cl,[Li]CCCC,val
US20130102776A1,C=O.CC(C)(C)OC(=O)N1CCCNCC1.O=C1COc2cc(O)ccc21>>CC(C)(C)OC(=O)N1CCCN(Cc2c(O)ccc3c2OCC3=O)CC1,,CCO,,,,val
US20040157839A1,CCCCN.Cc1nc(Cl)n2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)c2n1>>CCCCNc1nc(C)nc2c(-c3ccc(Cl)cc3)c(-c3ccccc3Cl)nn12,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20090270350A1,CC(C)(C)c1cc(N)n(-c2cccc(O[Si](C)(C)C(C)(C)C)c2)n1.O=C(Cl)Oc1ccccc1>>CC(C)(C)c1cc(NC(=O)Oc2ccccc2)n(-c2cccc(O[Si](C)(C)C(C)(C)C)c2)n1,,C1CCOC1,,c1ccncc1,,val
US20070213331A1,CCO.O=C(O)c1cc(Br)cc(N(Cc2ccccc2)Cc2ccccc2)c1F>>CCOC(=O)c1cc(Br)cc(N(Cc2ccccc2)Cc2ccccc2)c1F,O=S(=O)(O)O,,,,,val
US05256675,NC(N)=S.O=C(CCl)C(=O)c1ccc([N+](=O)[O-])cc1>>Nc1nc(C(=O)c2ccc([N+](=O)[O-])cc2)cs1,,CCO,,CC(=O)[O-].[Na+],,val
US20100261757A1,CC(=O)SCCN(Cc1ccc(Cl)nc1)CC(C)C>>CC(C)CN(CCS)Cc1ccc(Cl)nc1,,CCO,,CN,,val
US20040063704A1,C/C=C/C=O.COc1ccc(Cl)c(N)c1>>Cc1ccc2c(O)ccc(Cl)c2n1,,Cl,O,,,val
US20050113580A1,Cc1c(OCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(c2ccccc2)c2ccccc2)cccc1[N+](=O)[O-]>>Cc1c(N)cccc1OCCCN(Cc1cccc(C(F)(F)F)c1Cl)CC(c1ccccc1)c1ccccc1,[Pd],CO,,ClC(Cl)Cl,,val
US20030176454A1,Cc1ncn(-c2cccc(NC(N)=S)c2)c1C.O=C1Cc2ccccc2C1Cl>>Cc1ncn(-c2cccc(Nc3nc4c(s3)-c3ccccc3C4)c2)c1C,,CCO,,,,val
US05665718,CCCN.O=C1c2c(Cl)cccc2-n2cnc(-c3noc(CCl)n3)c2[C@@H]2CCN12>>CCCNCc1nc(-c2ncn3c2[C@@H]2CCN2C(=O)c2c(Cl)cccc2-3)no1,,CN(C)C=O,,,,val
US20020156081A1,CCc1ccc(O)c([N+](=O)[O-])c1>>CCc1ccc(O)c(N)c1,,CCO,O,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20070093526A1,Cc1cc(C(=O)O)n(C)n1.O=S(Cl)Cl>>Cc1cc(C(=O)Cl)n(C)n1,CN(C)C=O,,,,,val
US04243805,CC(=O)OC(C)=O.CC(C)c1ccc2c(c1)C(N1CCN(CCCO)CC1)Cc1ccc(F)cc1S2>>CC(=O)OCCN1CCN(C2Cc3ccc(F)cc3Sc3ccc(C(C)C)cc32)CC1,,ClC(Cl)Cl,,,,val
US20100216836A1,CC1(CO)CCCN(CC2COc3ccccc3O2)C1.CI>>COCC1(C)CCCN(CC2COc3ccccc3O2)C1,,C1CCOC1,,O,[H-].[Na+],val
US20150057273A1,CC(C)c1nnc2ccc(O[C@@H]3CC[C@H](N)c4ccccc43)cn12.CN(C)CCOc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)c1>>CC(C)c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCN(C)C)c4)c4ccccc43)cn12,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20090162283A1,Brc1ccc2[nH]c(-c3ccc(-c4cc[nH]n4)cc3)nc2c1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)n1ccc(-c2ccc(-c3nc4cc(Br)ccc4n3C(=O)OC(C)(C)C)cc2)n1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040242508A1,CO[C@@H]1[C@@H](CO)O[C@@H](n2c3ccccc3c3c4c(c5c6ccccc6[nH]c5c32)C(=O)NC4=O)[C@H](O)[C@H]1O.[OH-]>>CO[C@@H]1[C@@H](CO)O[C@@H](n2c3ccccc3c3c4c(c5c6ccccc6[nH]c5c32)C(=O)OC4=O)[C@H](O)[C@H]1O,,O,,Cl,,val
US05021412,C=C(Cl)CCl.N#Cc1ccc(O)cc1>>C=C(Cl)COc1ccc(C#N)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110245251A1,Cc1ccc(C2OC(=O)C(Br)=C2Br)cc1.NN>>Cc1ccc(-c2n[nH]c(=O)cc2Br)cc1,,CCO,,,,val
US20060211728A1,BrC1C=CCCC1.O=C1NC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1C1CC=CCC1,,CN(C)C=O,,[K],,val
US20110171739A1,COCCOCCOCCO.O=[N+]([O-])c1ccc(-c2nc3ccccc3s2)c(O)c1>>COCCOCCOCCOc1cc([N+](=O)[O-])ccc1-c1nc2ccccc2s1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120149679A1,CC(C)(C)OP(=O)(OCCl)OC(C)(C)C.Cn1nccc1-c1cc(Cl)ccc1Oc1ccc(S(=O)(=O)Nc2nccs2)cc1C#N>>Cn1nccc1-c1cc(Cl)ccc1Oc1ccc(S(=O)(=O)/N=c2\sccn2COP(=O)(OC(C)(C)C)OC(C)(C)C)cc1C#N,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060106013A1,O=[N+]([O-])c1ccc(C2CCN(CC3CC3)CC2)cc1>>Nc1ccc(C2CCN(CC3CC3)CC2)cc1,[Pd],C1CCOC1,CCO,[H][H],,val
US04610767,COS(=O)(=O)[O-].Cc1cccc2[nH+]c3ccccc3nc12>>Cc1cccc2nc3c(nc12)C=CCC3=O,,O,,[Na+].[OH-],,val
US04824830,C=C1[C@H](C)C2=CC(=O)C=C(C)[C@]2(C)[C@H]2CC[C@]3(C)C(=O)[C@H](F)C[C@H]3[C@H]12.CO>>C=C1[C@H]2[C@@H]3C[C@@H](F)C(=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)[C@H](C)CC(=O)C3OC32[C@@H]1C,,CO,,[Na+].[OH-],,val
US20090214444A1,O=C(NCCC#Cc1ccc2cc(O)ccc2c1)OCc1ccccc1.OCC1CO1>>O=C(NCCC#Cc1ccc2cc(OCC(O)CO)ccc2c1)OCc1ccccc1,,CCO,,CCN(CC)CC,,val
US04904300,CC1(C)SCc2ccccc2C1N.CCOC=NC#N>>CC1(C)SCc2ccccc2C1N=CNC#N,,CCO,,,,val
US04242278,CC1(C)C(Cl)C(=O)C1CC(Cl)(Cl)Cl.OCc1cccc(Oc2ccccc2)c1>>CC1(C)C(C=C(Cl)Cl)C1C(=O)O,,COCCOC,O,Cl,[H-].[Na+],val
US20120115850A1,CC(C)(C)OC(=O)N1CCNCC1.CC(Nc1cc(F)ccc1C(=O)C(F)(F)F)c1ccccc1>>CC(Nc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1C(=O)C(F)(F)F)c1ccccc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20060252812A1,BrCCCCCBr.NCCN1C(=O)C2(COc3cc4c(cc32)OCO4)c2ccccc21>>O=C1N(CCN2CCCCC2)c2ccccc2C12COc1cc3c(cc12)OCO3,,C1CCOC1,,CCN(CC)CC,,val
US05155250,C[Si](C)(C)CCl.Cc1cc(O)cc(C)c1O>>Cc1cc(OC[Si](C)(C)C)cc(C)c1O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160108027A1,COC(=O)[C@]1(C)CCCN1C(=O)c1cc(OC)c2oc(NCc3cc(Cl)ccn3)nc2c1>>COc1cc(C(=O)N2CCC[C@@]2(C)C(=O)O)cc2nc(NCc3cc(Cl)ccn3)oc12,,C1CCOC1,O,[Li+].[OH-],,val
US20120149691A1,N#Cc1cnn2cccc2c1Cl.NC1CCCC(O)C1>>N#Cc1cnn2cccc2c1NC1CCCC(O)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05798375,CI.COc1ccc([N+](=O)[O-])c(NC(=O)OC(C)(C)C)c1>>COc1ccc([N+](=O)[O-])c(N(C)C(=O)OC(C)(C)C)c1,,CN(C)C=O,,[H-].[Na+],,val
US20080004302A1,Cc1cc(CNc2nccc(Cl)n2)on1.Nc1cc(CCc2cccc(Oc3ncccn3)c2)[nH]n1>>Cc1cc(CNc2nccc(Nc3cc(CCc4cccc(Oc5ncccn5)c4)[nH]n3)n2)on1.Cl,,CCO,,,,val
US05891909,Cc1cc(O)cc(OS(=O)(=O)c2cccc3nsnc23)c1.OCCCO>>Cc1cc(OCCCO)cc(OS(=O)(=O)c2cccc3nsnc23)c1,,C1CCOC1,CCCCCC,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20050181393A1,COc1cc(OC)c(-c2cc(CN3CCN(C(=O)OC(C)(C)C)CCN(C(=O)OC(C)(C)C)CC3)nc(C(=O)NCCNC(=O)C(F)(F)F)c2)c(OC)c1>>COc1cc(OC)c(-c2cc(CN3CCNCCNCC3)nc(C(=O)NCCNC(=O)C(F)(F)F)c2)c(OC)c1,,O=C(O)C(F)(F)F,,,,val
US05270308,CC1(C)N=C(c2ccccn2)c2cc(Br)c(Cl)cc2O1.O=C(OO)c1cccc(Cl)c1>>CC1(C)N=C(c2cccc[n+]2[O-])c2cc(Br)c(Cl)cc2O1,,ClCCl,O,O=S([O-])[O-].[Na+].[Na+],,val
US20160152623A1,NO.O=Cc1cc(Cl)ccc1Cn1c(=S)[nH]c(=O)c2[nH]ccc21>>NCc1cc(Cl)ccc1Cn1c(=S)[nH]c(=O)c2[nH]ccc21,[Zn],CC(=O)O,,Cl,[Na+].[OH-],val
US05378689,CN.C[C@@H]1C[C@@H]([C@H](CC2CCCCC2)NC(=O)OC(C)(C)C)OC1=O>>CNC(=O)[C@H](C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C,,CO,,,,val
US20070072911A1,COC(=O)c1ccc(NC(=O)C(F)(F)F)c(C#Cc2ccccc2)c1.O=S(=O)(OC1=CCCCC1)C(F)(F)F.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1ccc2[nH]c(-c3ccccc3)c(C3=CCCCC3)c2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US06632919B1,COC(=O)CNCCNC(=O)OC(C)(C)C.Cc1ccnc2[nH]c(=O)c(CC(=O)O)cc12>>COC(=O)CN(CCNC(=O)OC(C)(C)C)C(=O)Cc1cc2c(C)ccnc2[nH]c1=O,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20110190303A1,COC(=O)c1ccc(OC2CCCC2)c2oc(CBr)cc12.O>>COC(=O)c1ccc(OC2CCCC2)c2oc(C=O)cc12,,CS(C)=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20070259874A1,CC(=O)OC(C)=O.COc1ccc(C2=NOC(C)(C(=N)NO)C2)cc1OC1CCCC1.ClCCl>>COc1ccc(C2=NOC(C)(/C(N)=C/OC(C)=O)C2)cc1OC1CCCC1,,ClCCl,,CCN(CC)CC,,val
US20160237059A1,CC(=O)O.CCOC(=O)C(=NO)C(C)=O>>CCOC(=O)C(NC(C)=O)C(C)=O,[Pd],CC(=O)OC(C)=O,,,,val
US20160137637A1,Nc1nncs1.O=C(O)c1csc(-c2ccc3c(c2)CCO3)n1>>O=C(Nc1nncs1)c1csc(-c2ccc3c(c2)CCO3)n1,,c1ccncc1,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20080032971A1,CC(C)(C)OC(=O)Nc1ccc(O)cc1.ClCCN1CCOCC1>>CC(C)(C)OC(=O)Nc1ccc(OCCN2CCOCC2)cc1,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05952368,Cc1cc(Cc2ccc(N)cc2)n(C)c1C(=O)c1ccc(Cl)cc1.NCCO.O=C(n1ccnc1)n1ccnc1>>Cc1cc(Cc2ccc(NC(=O)NCCO)cc2)n(C)c1C(=O)c1ccc(Cl)cc1,,CN(C)C=O,O,,,val
US20090209522A1,COc1nc(NCCN(C)C(=O)OC(C)(C)C)nc(OC)c1[N+](=O)[O-]>>COc1nc(NCCN(C)C(=O)OC(C)(C)C)nc(OC)c1N,,CCO,,,,val
US20060211709A1,CC(C)(C)OC(=O)N1CCCC[C@H](NC(c2ccccc2)(c2ccccc2)c2ccccc2)C1>>CC(C)(C)OC(=O)N1CCCC[C@H](N)C1,[Pd],CCO,,CO,[H][H],val
US20120309754A1,Cc1nc2ccccc2nc1-c1cc2nc(N3CCCC3)cc(NC3CCOCC3)n2n1.Cl>>Cc1nc2ccccc2nc1-c1cc2nc(N3CCCC3)cc(NC3CCOCC3)n2n1.Cl,,CCO,,O,,val
US20150141372A1,CCOc1cc(F)c(CBr)c(F)c1.N#Cc1n[nH]c2c1CCC2>>CCOc1cc(F)c(Cn2nc(C#N)c3c2CCC3)c(F)c1,,CN(C)C=O,O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],val
US20100197699A1,CCOC(=O)C1CCC2(CC1)CN(c1ccccc1)C(=O)O2>>O=C(O)C1CCC2(CC1)CN(c1ccccc1)C(=O)O2,,CO,O,Cl,[Li+].[OH-],val
US06175021B1,C1CCOC1.COc1cccc(NC(=O)OC(C)(C)C)c1C.[Li]C(C)CC>>CCCC(=O)Cc1c(NC(=O)OC(C)(C)C)cccc1OC,,C1CCCCC1,,,,val
US20040131648A1,CC1(C)CCCC2=C1CC(C(O)c1ccc(CO)cc1)CC2>>CC1(C)CCCC2=C1CC(C(=O)c1ccc(C=O)cc1)CC2,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US04400461,CO.Cc1ccc(C(=O)O)cc1[N+](=O)[O-]>>COC(=O)c1ccc(C)c([N+](=O)[O-])c1,,O,,O=S(=O)(O)O,,val
US20130023055A1,COC(=O)CN(CC(=O)OC)c1ccc(C)cc1OCCOc1ccccc1NC(C(=O)OC)C(=O)OC.O=[N+]([O-])O>>COC(=O)CN(CC(=O)OC)c1ccc(C)cc1OCCOc1cc([N+](=O)[O-])ccc1NC(C(=O)OC)C(=O)OC,,CC(=O)O,,O=S(=O)(O)O,,val
US20060128722A1,N#Cc1ccc2cc[nH]c2c1.O=[N+]([O-])c1ccccc1SCl>>N#Cc1ccc2c(Sc3ccccc3[N+](=O)[O-])c[nH]c2c1,,CCOCC,,,,val
US20140179670A1,CCOC(C#Cc1c(C)n(-c2cccc(C(F)(F)F)c2)c(=O)n(C)c1=O)OCC.N#Cc1ccc(NN)cc1>>Cc1c(-c2ccnn2-c2ccc(C#N)cc2)c(=O)n(C)c(=O)n1-c1cccc(C(F)(F)F)c1,,CN(C)C=O,,Cl,O,val
US20100183564A1,CC(C)n1cnc2c(Cl)nc(I)nc21.OB(O)c1csc2ccccc12>>CC(C)n1cnc2c(Cl)nc(-c3csc4ccccc34)nc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20040167160A1,CCCOc1c(-c2cccc3cc(C(C)=O)oc23)cc(CC)cc1C(C)(C)C.CCOC(=O)C(F)P(=O)(OCC)OCC>>CCCOc1c(-c2cccc3cc(C(C)=C(F)C(=O)OCC)oc23)cc(CC)cc1C(C)(C)C,,CN(C)C=O,,O,[H-].[Na+],val
US20070259863A1,CCOC(=O)C1CCN(C(=O)C=Cc2ccc(Sc3cccc(NC4CCN(C)CC4)c3)c(C(F)(F)F)c2C(F)(F)F)CC1>>CN1CCC(Nc2cccc(Sc3ccc(C=CC(=O)N4CCC(C(=O)O)CC4)c(C(F)(F)F)c3C(F)(F)F)c2)CC1,,CCO,,[Li+].[OH-],,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC3(CC2)OCCO3)c2ncnn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(C2CCC3(CC2)OCCO3)c2ncnn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20110281870A1,CC(C)C[C@@H](C(=O)N[C@H]1CC[C@@H]2CN(c3ccccc3F)C[C@H]12)N(C)C(=O)OC(C)(C)C>>CN[C@@H](CC(C)C)C(=O)N[C@H]1CC[C@@H]2CN(c3ccccc3F)C[C@H]12,,Cl,,C1COCCO1,,val
US20110009390A1,C1CNCCNC1.O=[N+]([O-])c1ccc(Cl)cc1>>O=[N+]([O-])c1ccc(N2CCCNCC2)cc1,,CCCCO,,,,val
US05977130,O=C(c1ccccn1)c1ccccn1.O=C1Cc2ccccc2N1>>O=C1Nc2ccccc2C1=C(c1ccccn1)c1ccccn1,,CC(=O)O,,C,O=C[O-].[NH4+],val
US08933104B2,COC(=O)c1ccc(C(C)O)nc1.CS(=O)(=O)Cl>>COC(=O)c1ccc(C(C)OS(C)(=O)=O)nc1,CN(C)c1ccncc1,ClCCl,,,,val
US20120270875A1,COC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1c(C)nc(NCC#Cc2ccc(O)cc2)nc1C>>COC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1c(C)nc(NCCCc2ccc(O)cc2)nc1C,[Pd],CO,,,,val
US20140171430A1,Cc1nc(Cl)ncc1F.O=C(c1cccc(F)c1-c1ncco1)N1CC2CNCC2C1>>Cc1nc(N2CC3CN(C(=O)c4cccc(F)c4-c4ncco4)CC3C2)ncc1F,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20030232869A1,CO.Nc1c([N+](=O)[O-])cc(C(=O)O)c(F)c1Cl>>COC(=O)c1cc([N+](=O)[O-])c(N)c(Cl)c1F,,C1CCOC1,CO,C[Si](C)(C)C=[N+]=[N-],,val
US03954894,C=C(C)c1cccc(C(=C)C)c1.[Li]C(C)CC>>[Li]C(C)(CC(C)CC)c1cccc(C(=C)C)c1,,c1ccccc1,,CCCCCC,,val
US06211234B1,ClCc1ccsc1.O=c1oc2cc(O)ccc2s1>>O=c1oc2cc(OCc3ccsc3)ccc2s1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130210768A1,CI.Cn1c(=O)n(CC(C)(C)C)c2ccc(-c3cccc(CC#N)c3)nc21>>CC(C#N)c1cccc(-c2ccc3c(n2)n(C)c(=O)n3CC(C)(C)C)c1,,C1CCOC1,CO,,,val
US20070123592A1,C=Cc1ccc(C(=O)OC)cc1OC(C)C>>C=Cc1ccc(C(=O)O)cc1OC(C)C,,CO,,[Na+].[OH-],,val
US04554012,Cc1cc(O)ccc1Cl.Cc1cccc(N(C)C(=S)Cl)n1>>Cc1cccc(N(C)C(=S)Oc2ccc(Cl)c(C)c2)n1,,CCC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080004274A1,COC(=O)c1ccc(CCSc2ccc3c(c2)C(OC)(OC)C(=O)N3CCc2ccccc2)cc1>>COC(=O)c1ccc(CCSc2ccc3c(c2)C(=O)C(=O)N3CCc2ccccc2)cc1,,CC(C)=O,,Cl,,val
US06069157,N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1-c1ccccc1C(F)(F)F>>N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)cc1-c1ccccc1C(F)(F)F,,C1CCOC1,,CC(C)(C)ON=O,,val
US20040106606A1,Cc1ccc(S(=O)(=O)Sc2cc(NC(=O)OC(C)(C)C)c(NC(=O)OC(C)(C)C)cc2C(C)(C)C)cc1>>Cc1ccc(S(=O)(=O)Sc2cc(N)c(N)cc2C(C)(C)C)cc1,,ClCCl,,Cl,,val
US05244863,Cc1cn(-c2cccc(C(F)(F)F)c2)c(=N)s1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1cn(-c2cccc(C(F)(F)F)c2)c(=NC(=O)C(F)(F)F)s1,,CCOC(C)=O,,CCN(CC)CC,Cl,val
US20120094972A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Clc1cnc2c(c1)NCCS2>>CC(C)(C)OC(=O)N1CCSc2ncc(Cl)cc21,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,,val
US20040220200A1,CCOC(=O)c1[nH]c(C)c(-c2ccnc(NC(C)C)n2)c1C>>Cc1[nH]c(C(=O)O)c(C)c1-c1ccnc(NC(C)C)n1,,CO,,Cl,[Na+].[OH-],val
US20140350246A1,CCC(Br)C(=O)Br.NOCc1ccccc1>>CCC(Br)C(=O)NOCc1ccccc1,,CCOC(C)=O,,Cl,,val
US05580883,CC(=O)N1CCC(Oc2ccc([N+](=O)[O-])cc2)CC1>>CC(=O)N1CCC(Oc2ccc(N)cc2)CC1,[Pd],CCO,,Cl,,val
US04954498,COc1ccc(C=O)cc1.Nc1cc2nc[nH]c(=O)c2cc1N>>COc1ccc(-c2nc3cc4nc[nH]c(=O)c4cc3[nH]2)cc1,,CO,,O=S([O-])O.[Na+],,val
US20150141433A1,COC(=O)c1ccc(CNC(=O)c2cc(F)cc(F)c2)cn1>>O=C(NCc1ccc(C(=O)O)nc1)c1cc(F)cc(F)c1,,CO,O,Cl,[K+].[OH-],val
US05571833,CCCI.Oc1ccc2[nH]ccc2c1>>CCCOc1ccc2[nH]ccc2c1,,CN(C)C=O,,O,[H-].[Na+],val
US20090124625A1,BrCCCCC#Cc1ccccn1.c1ccc2[nH]nnc2c1>>C(#Cc1ccccn1)CCCCn1nc2ccccc2n1,,C1CCCCC1,CCOC(C)=O,,,val
US20060241302A1,CC(C)(C)OC(=O)NCCNC(=O)c1ccc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)nc1>>NCCNC(=O)c1ccc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)nc1,,CCO,,Cl,,val
US20080009486A1,O=C(O)c1cc(I)ccc1[N+](=O)[O-]>>O=Cc1cc(I)ccc1[N+](=O)[O-],,C1CCOC1,,B,,val
US20130090323A1,C1COCCN1.O=[N+]([O-])c1ccnc(Cl)c1>>O=[N+]([O-])c1ccnc(N2CCOCC2)c1,,C1CCOC1,,,,val
US20090023800A1,CCOC(=O)/C=C/c1ccc(C2COc3c(C)c(C)c(NC(=O)CC(C)(C)C)c(C)c32)cc1>>CCOC(=O)CCc1ccc(C2COc3c(C)c(C)c(NC(=O)CC(C)(C)C)c(C)c32)cc1,,CCCCCC,CCOC(C)=O,,,val
US05955495,CCC=O.COc1cccc(F)c1>>CCC(O)c1c(F)cccc1OC,,C1CCOC1,CCCCCC,Cl,[Li]CCCC,val
US20160002225A1,CN(C/C=C/C(=O)O)C1CC1.Cc1cnc(NC(=O)c2ccc(Oc3ccnc4[nH]nc(N[C@@H]5CCCNC5)c34)cc2)s1>>Cc1cnc(NC(=O)c2ccc(Oc3ccnc4[nH]nc(N[C@@H]5CCCN(C(=O)/C=C/CN(C)C6CC6)C5)c34)cc2)s1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US03955028,CC(C)(CBr)C(Br)(Br)OP(=O)(Cl)OC(Br)(Br)C(C)(C)CBr.O>>CC(C)(CBr)C(Br)(Br)OP(=O)(O)OC(Br)(Br)C(C)(C)CBr,,c1ccccc1,,,,val
US06211199B1,CCOC(=O)CCCOc1ccc(-n2cnnn2)cc1C(=O)N1CCC(CCO)(c2ccccc2)C1.CS(=O)(=O)Cl>>CCOC(=O)CCCOc1ccc(-n2cnnn2)cc1C(=O)N1CCC(CCOS(C)(=O)=O)(c2ccccc2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160229816A1,Cc1csc2ccc(F)cc12.II>>Cc1c(I)sc2ccc(F)cc12,,C1CCOC1,,[Li]CCCC,,val
US04182776,CS(=O)(=O)Cl.OCCCCCCOc1ccc2ccccc2c1>>CS(=O)(=O)OCCCCCCOc1ccc2ccccc2c1,,ClCCl,,CCN(CC)CC,,val
US20090239854A1,Brc1cccnc1.C#CCn1c2c(c3cc(C)ccc31)CN(C)CC2>>Cc1ccc2c(c1)c1c(n2CC#Cc2ccccn2)CCN(C)C1,[Cu]I,CC#N,,CCN(CC)CC,,val
US20100075983A1,CC(C)(C)OC(=O)N1CCN(/C(=N/O)c2cc(F)ccc2F)CC1>>CC(C)(C)OC(=O)N1CCN(c2noc3ccc(F)cc23)CC1,,C1COCCO1,O,[K+].[OH-],,val
US20090149501A1,CS(=O)(=O)Cl.OCCc1ccncc1>>CS(=O)(=O)OCCc1ccncc1,,C1CCOC1,,CCN(CC)CC,,val
US20100323994A1,NC1CCC1.NC1CCCCC1.O=C(Nc1ccncc1F)c1cnc2c(Br)cc(Cl)nn12>>O=C(Nc1ccncc1F)c1cnc2c(NC3CCC3)cc(NC3CCCCC3)nn12,,CO,,C1CCOC1,,val
US20090298866A1,CC(C)Cc1cn(-c2nc(-c3nc4cc(CO)ccc4[nH]3)cs2)c2cc(Cl)ccc12>>CC(C)Cc1cn(-c2nc(-c3nc4cc(C=O)ccc4[nH]3)cs2)c2cc(Cl)ccc12,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20110190269A1,COc1cc(Br)ccc1-n1cnc(C)c1.Nc1nc2cccc(N3CCCCC3)n2n1>>COc1cc(Nc2nc3cccc(N4CCCCC4)n3n2)ccc1-n1cnc(C)c1,,CO,ClCCl,,,val
US20060024330A1,CC(C)(C)OC(=O)N1CCNC(=O)C1.N#Cc1cccc(CBr)c1>>CC(C)(C)OC(=O)N1CCN(Cc2cccc(C#N)c2)C(=O)C1,,CN(C)C=O,,CC(=O)O,[H-].[Na+],val
US20090253677A1,CCOC(=O)C1=C(OS(C)(=O)=O)CNC(C2(NC(=O)OCc3ccccc3)CCC(COS(C)(=O)=O)CC2)=N1>>CCOC(=O)c1nc2n(c(=O)c1O)CC1CCC2(NC(=O)OCc2ccccc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05138048,O=C1CCCCC1O.OCCOCc1ccccc1>>O=C1CCCCC1OCCOCc1ccccc1,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05936123,COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)C)cc1C(C)C.O=C(O)CC(O)(CC(=O)O)C(=O)O>>COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)C)cc1C(C)C.O=C(O)CC(O)(CC(=O)O)C(=O)O,,CCO,ClCCl,,,val
US20110269956A1,CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1ncc(-c2ccc3cc(-c4ccc(-c5cnc(C6C[C@H]7C[C@H]7N6C(=O)OCc6ccccc6)[nH]5)cc4)ccc3c2)[nH]1>>CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1ncc(-c2ccc3cc(-c4ccc(-c5c[nH]c([C@@H]6C[C@H]7C[C@H]7N6)n5)cc4)ccc3c2)[nH]1,[Pd],CO,,,,val
US20110009399A1,CC(C)(C)OC(=O)N1CC=C(OS(=O)(=O)C(F)(F)F)CC1.COCCCOc1ccc(B(O)O)c(CCO[Si](C(C)C)(C(C)C)C(C)C)c1>>COCCCOc1ccc(C2=CCN(C(=O)OC(C)(C)C)CC2)c(CCO[Si](C(C)C)(C(C)C)C(C)C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,[Cl-].[Na+],O=C([O-])[O-].[Li+],val
US20120225844A1,Cc1ccc(O)cc1.O=C1c2cc(CO)nn2CCN1c1ccc(F)cc1>>Cc1ccc(OCc2cc3n(n2)CCN(c2ccc(F)cc2)C3=O)cc1,,C1CCOC1,CCOC(C)=O,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090137557A1,CC(=O)O.CCOC(C)=O.Cc1cc(=O)n(CCc2ccccc2)c(-c2ccccc2)n1>>Cc1nc(-c2ccccc2)n(CCc2ccccc2)c(=O)c1-c1ccccc1,,CC(=O)O,,BrBr,,val
US20040014108A1,CC(=O)Nc1ncnc2c1ccn2[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@@]1(C)OC(C)=O.O=C1CCC(=O)N1Br>>CC(=O)Nc1ncnc2c1c(Br)cn2[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@@]1(C)OC(C)=O,,CN(C)C=O,,,,val
US20030134867A1,O=C1CN(C(=O)Cc2ccc(F)cc2)N(C(=O)OCc2ccccc2)C1>>O=C(Cc1ccc(F)cc1)N1CC(O)CN1C(=O)OCc1ccccc1,,C1CCOC1,,CCOCC,,val
US20130316981A1,CC(C)(C)OC(=O)NC1CCN(CC(=O)O)CC1.Nc1ccccc1>>CC(C)(C)OC(=O)NC1CCN(CC(=O)Nc2ccccc2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20150045340A1,N#Cc1ccc(OCCO)c(N)c1.O=C1c2ccccc2C(=O)N1O>>N#Cc1ccc(OCCON2C(=O)c3ccccc3C2=O)c(N)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05968944,CC(C)=O.CCOC[C@H]1Cc2ccccc2CN1Cc1c(CC)nn(-c2c(C)cc(Br)cc2C)c1CC>>CCOC[C@H]1Cc2ccccc2CN1Cc1c(CC)nn(-c2c(C)cc(C(C)(C)O)cc2C)c1CC,,C1CCOC1,,[Li]CCCC,,val
US03992535,CCOC(=O)C1=C(O)c2ccc3ccccc3c2S(=O)(=O)N1C.Nc1cccc(Cl)c1>>CN1C(C(=O)Nc2cccc(Cl)c2)=C(O)c2ccc3ccccc3c2S1(=O)=O,,ClCCCl,,,,val
US20120225062A1,CC(C)I.COC(=O)c1cccc(-c2c(F)cc(O)cc2F)n1>>COC(=O)c1cccc(-c2c(F)cc(OC(C)C)cc2F)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080004271A1,Cc1ccc(-c2nc(NC3CC3)nc(O)c2C#N)cc1C.O=P(Cl)(Cl)Cl>>Cc1ccc(-c2nc(NC3CC3)nc(Cl)c2C#N)cc1C,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20060211720A1,CCc1ccc(F)cc1Cl.COC(Cl)Cl>>CCc1cc(C=O)c(F)cc1Cl,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US07709479B1,BrC(Br)(Br)Br.OCCCN1C=NCC1>>BrCCCN1C=NCC1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20030134853A1,CCOC(=N)c1ccc(O)cc1.COC(=O)c1cnc(NC2CCCCC2)c([N+](=O)[O-])c1>>COC(=O)c1cnc2c(c1)nc(-c1ccc(O)cc1)n2C1CCCCC1,,CO,,Cl,,val
US20030176693A1,BrC(Br)(Br)Br.CCN(CC)C(=O)c1ccc(C(CCO)c2cccc(OC)c2)cc1>>CCN(CC)C(=O)c1ccc(C(CCBr)c2cccc(OC)c2)cc1,,CC#N,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120208817A1,CC(=O)OC(C)=O.CCOc1cc(C2NC(=O)NC(c3ccc(N)cc3)=C2c2ccccc2)cc([N+](=O)[O-])c1O>>CCOc1cc(C2NC(=O)NC(c3ccc(NC(C)=O)cc3)=C2c2ccccc2)cc([N+](=O)[O-])c1O,,ClCCl,,,,val
US20100063054A1,Clc1ccc(CBr)nn1.N>>Br.NCc1ccc(Cl)nn1,,CO,,,,val
US20090118312A1,COc1ccc(CN2CCCCCC=CC3CC3(C(=O)NS(=O)(=O)C3CC3)NC(=O)C3CC(Oc4nc(-c5ccccc5)nc5c(C)c(OC)ccc45)CN3C2=O)cc1>>COc1ccc2c(OC3CC4C(=O)NC5(C(=O)NS(=O)(=O)C6CC6)CC5C=CCCCCCNC(=O)N4C3)nc(-c3ccccc3)nc2c1C,,ClCCl,O=C(O)C(F)(F)F,,,val
US04113464,CCOCC.CNCC=O.O=C(Cl)CCl>>COC(CN(C)C(=O)CCl)OC,,ClCCl,,CCN(CC)CC,,val
US20030195223A1,COC(=O)c1ccc(CN(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(C#N)c1>>CC(C)(C)OC(=O)N(Cc1ccc(C(=O)O)cc1C#N)C(=O)OC(C)(C)C,,C1CCOC1,,CO,[Li+].[OH-],val
US20050222210A1,CCOC(=O)C1CCNCC1.CI>>CN1CCC(C(=O)O)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100303928A1,CCOC(=O)c1ncc2onc(-c3ccccc3)c2c1O.O=C1CCC(=O)N1Br>>CCOC(=O)c1nc(Br)c2onc(-c3ccccc3)c2c1O,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20160235717A1,Cn1c(CCCC(=O)O)nc2cc(N(CCCl)CCCl)ccc21.OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>Cn1c(CCCC(=O)O)nc2cc(N(CCCl)CCCl)ccc21.OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,,CS(C)=O,,Cl,,val
US20100160387A1,CCOC(=O)Cc1cc(OCCO[Si](C)(C)C(C)(C)C)c(F)cc1Br>>CC(C)(C)[Si](C)(C)OCCOc1cc(CC(=O)O)c(Br)cc1F,,CO,,O,[Li]O,val
US20070167452A1,OC[C@H]1CC[C@@H](CNCc2ccccc2)CC1>>NC[C@@H]1CC[C@H](CO)CC1,,CO,,,,val
US20060241115A1,COc1cc2nccc(Oc3ccc4c(N)cccc4c3)c2cc1OC.S=C(c1ncc[nH]1)c1ncc[nH]1>>COc1cc2nccc(Oc3ccc4c(N=C=S)cccc4c3)c2cc1OC,,ClCCl,,CCN(CC)CC,,val
US03988338,CCCCCCNc1nc(SC)[nH]c2nccc1-2>>CCCCCCNc1nc[nH]c2nccc1-2,[Ni],,,,,val
US20100190747A1,Nc1ccc(OCC(F)(F)F)cc1.S=C(Cl)Cl>>FC(F)(F)COc1ccc(N=C=S)cc1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US04012499,N#Cc1ccc2c(=O)c3ccccc3sc2c1.[N-]=[N+]=[N-]>>O=c1c2ccccc2sc2cc(-c3nnn[nH]3)ccc12,,CN(C)C=O,,[Cl-].[NH4+],,val
US20140243346A1,CCOC(=O)CCCCCCN1CC=Cc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc21.OO>>CCOC(=O)CCCCCCN1CC(O)Cc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc21,,C1CCOC1,,[Na+].[OH-],,val
US20110245236A1,CC(C)(C)OC(=O)NC1CCNCC1.ClCc1ccc(-c2nnc3n2-c2cccnc2Nc2ccccc2-3)cc1>>CC(C)(C)OC(=O)NC1CCN(Cc2ccc(-c3nnc4n3-c3cccnc3Nc3ccccc3-4)cc2)CC1,,CC(=O)N(C)C,O,CCN(CC)CC,,val
US20080045556A1,CC(C)(CO)Nc1nc(-c2ccc(C#N)cc2)c(Cl)s1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC1(C)COC(=O)N1c1nc(-c2ccc(C#N)cc2)c(Cl)s1,,ClCCl,,CCN(CC)CC,,val
US20130331374A1,CC(C)Oc1cc(F)ccc1N=C=O.C[Si](C)(C)N=[N+]=[N-]>>CC(C)Oc1cc(F)ccc1-n1nn[nH]c1=O,,CCOC(C)=O,,,,val
US20060074126A1,COc1ccc(C2=C(c3ccc(O)cc3)COc3cc(O)ccc32)cc1>>COc1ccc(C2c3ccc(O)cc3OCC2c2ccc(O)cc2)cc1,,CCO,,,,val
US20100121048A1,CS(N)(=O)=O.Cc1cc(C(=O)N2CCN(Cc3ccccc3)CC2Cc2ccc(OCC(=O)O)cc2)c(-c2ccccc2)n1-c1ccccc1>>Cc1cc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2Cc2ccc(OCC(=O)NS(C)(=O)=O)cc2)c(-c2ccccc2)n1-c1ccccc1,,CN(C)C=O,,C1CCC2=NCCCN2CC1,O,val
US04616007,Cn1nnnc1SCCCC(=O)Cl.S>>Cn1nnnc1SCCCC(O)=S,,ClC(Cl)Cl,ClCCl,c1ccncc1,,val
US20110028463A1,CN(C)C=O.Cc1cc2cccc(C(=O)O)c2n1Cc1ccc(Cl)cc1>>COC(=O)c1cccc2c(C)cn(Cc3ccc(Cl)cc3)c12,,O,,O=P(Cl)(Cl)Cl,O=C([O-])O.[Na+],val
US20100323994A1,N[C@H]1CC[C@H](N)CC1.Nc1ccccn1.O=C(Nc1ccncc1F)c1cnc2c(Cl)cc(Cl)nn12>>N[C@@H]1CC[C@@H](Nc2cc(Nc3ccccn3)c3ncc(C(=O)Nc4ccncc4F)n3n2)CC1,,C1CCOC1,CO,CC(C)(C)[O-].[K+],,val
US04743614,COC(=O)[C@@H]1CN1S(=O)(=O)c1ccc(C)cc1.N[C@@H](Cc1c[nH]cn1)C(=O)O>>Cc1ccc(S(=O)(=O)N[C@@H](CN[C@@H](Cc2c[nH]cn2)C(=O)O)C(=O)O)cc1,,CO,,[Na+].[OH-],,val
US20120214735A1,BrC1CCCC1.Sc1ccc(Br)cn1>>Brc1ccc(SC2CCCC2)nc1,,CS(C)=O,,,,val
US20060074075A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc2c(c1)C(N)CCC2>>CC(C)(C)OC(=O)NC1CCCc2ccc(N)cc21,,CO,,CCN(CC)CC,,val
US20140316154A1,CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](/N=C1\C[C@@H]2C[C@@H](C2(C)C)[C@]1(C)O)C(=O)OC(C)C.CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](/N=C1\C[C@@H]2C[C@@H](C2(C)C)[C@]1(C)O)C(=O)OCC>>CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)C(=O)OC(C)C.CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)C(=O)OCC,,C1CCOC1,,Cl,,val
US05866612,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc(N)c(C)c1N.ClCCl>>CC(C)(C)OC(=O)NCc1cccc(CN)c1,,C1CCOC1,ClCCl,CCN(CC)CC,CO,val
US20160214971A1,CS(N)(=O)=O.O=C(O)c1ccc(Br)c(Cl)c1>>CS(=O)(=O)NC(=O)c1ccc(Br)c(Cl)c1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20070066588A1,CC(C)OB1OC(C)(C)C(C)(C)O1.Cc1ccc(Br)c(C)n1>>Cc1ccc(B2OC(C)(C)C(C)(C)O2)c(C)n1,,CCOCC,,[Li]CCCC,,val
US06664256B1,Br[Mg]c1ccccc1.COc1ccc(-c2cc(Cl)nnc2-c2ccc(OC)cc2)cc1>>COc1ccc(-c2cc(-c3ccccc3)nnc2-c2ccc(OC)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,c1ccccc1,,ClCCl,O,val
US20090186886A1,CC(=O)Nc1ccc2c(c1)OCO2.O=[N+]([O-])O>>CC(=O)Nc1cc2c(cc1[N+](=O)[O-])OCO2,,CC(=O)O,,,,val
US06049009,CO/C=C/C(C)=O.Sc1ccccc1>>CC(=O)/C=C/Sc1ccccc1,,c1ccccc1,,O=C([O-])O.[Na+],,val
US20020151535A1,CNCc1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1.CS(=O)(=O)Cl>>CN(Cc1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1)S(C)(=O)=O,,c1ccncc1,,,,val
US04548932,CCOC(=O)[C@H](CCCCCCC1CCN(C(=O)OCc2ccccc2)CC1)N[C@H]1COc2ccccc2N(CC(=O)OC(C)(C)C)C1=O>>O=C(O)CN1C(=O)[C@@H](N[C@@H](CCCCCCC2CCNCC2)C(=O)O)COc2ccccc21,,CC(=O)O,CCOCC,Br,,val
US04138394,CCOC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C>>CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)O,,CO,,[Na+].[OH-],,val
US20130072467A1,NCC(O)CO.O=C1NC(=S)CS1>>O=C1N=C(NCC(O)CO)CS1,,CCO,,,,val
US05162359,COc1ccc(Cc2ccc(N)c(N)c2)cc1.S=C(Cl)Cl>>COc1ccc(Cc2ccc3[nH]c(=S)[nH]c3c2)cc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20070049593A1,COC(=O)c1ccc2c(C3CCCCC3)c(Br)n(CCO)c2c1.CS(=O)(=O)Cl>>COC(=O)c1ccc2c(C3CCCCC3)c(Br)n(CCOS(C)(=O)=O)c2c1,,ClC(Cl)Cl,,CCN(CC)CC,O,val
US20040220403A1,COC(=O)CC(=O)N1CCN2[C@H](CN(Cc3cc(-n4nnnc4C(F)(F)F)ccc3OC)C[C@H]2C(c2ccccc2)c2ccccc2)C1>>COc1ccc(-n2nnnc2C(F)(F)F)cc1CN1C[C@@H]2CN(C(=O)CC(=O)O)CCN2[C@H](C(c2ccccc2)c2ccccc2)C1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20080021026A1,COc1cccc([Mg]Br)c1.Cc1c(-c2ccnc(N)n2)sc2ccc(C#N)cc12>>COc1cccc(C(N)c2ccc3sc(-c4ccnc(N)n4)c(C)c3c2)c1,,CO,,C1CCOC1,[BH4-].[Na+],val
US05741796,COC(=O)c1ccc(COCCNC(=O)OCc2ccccc2)cc1>>O=C(NCCOCc1ccc(C(=O)O)cc1)OCc1ccccc1,,CO,,[Na+].[OH-],,val
US20070049518A1,CNC(=O)[C@@H](NC(=O)[C@@H](CC(C)C)C(C(=O)O)C(=O)O)C(C)(C)C>>CNC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)CC(C)C)C(C)(C)C,,CCO,,,,val
US20140336052A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1CC2CC3CCCC=C3C2N1>>CC(C)(C)OC(=O)N1C(=O)CC2CC3CCCC=C3C21,,ClCCl,,CCN(CC)CC,O,val
US20080096874A1,CCOC(=O)C(C)[C@@H]1CC[C@@H](c2ccc(NC(=O)C(=O)OC)cc2)CC1.NN>>CCOC(=O)C(C)[C@@H]1CC[C@@H](c2ccc(NC(=O)C(=O)NN)cc2)CC1,,CCO,,O,,val
US20100216746A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)c1nc2cc(N)ccc2[nH]1>>CC(=O)Nc1ccc2[nH]c(C(=O)OC(C)(C)C)nc2c1,,ClCCl,,c1ccncc1,,val
US20110034450A1,CCCC(C)C(C(=O)Nc1cccc(CCC(=O)OC(C)(C)C)c1C)c1ccc(CN2N=C(c3ccccc3)OCC2=O)cc1>>CCCC(C)C(C(=O)Nc1cccc(CCC(=O)O)c1C)c1ccc(CN2N=C(c3ccccc3)OCC2=O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080167307A1,CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCOc2ccc(-c3ccc(F)cc3)nn2)cs1>>CC(C)(Sc1nc(CCOc2ccc(-c3ccc(F)cc3)nn2)cs1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140336224A1,CCCNN.N#CCCC(C(=O)c1ccccc1F)c1ccc(Cl)cc1F>>CCCn1nc(C(CCC#N)c2ccc(Cl)cc2F)c2ccccc21,,c1ccncc1,,O=C(O)C(=O)O,,val
US20040157838A1,Cc1cc(O)n2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)c2n1.O=P(Cl)(Cl)Cl>>Cc1cc(Cl)n2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)c2n1,,CCOC(C)=O,Cc1ccccc1,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US04271163,NN.O=C(O)[C@@H]1C[C@@H]1C(=O)c1ccc(Cl)cc1>>O=C1NN=C(c2ccc(Cl)cc2)C2CC12,,CCO,,O,,val
US20110105471A1,CC(C)[C@H](O)C(=O)N[C@@H](C)C(=O)N[C@@H]1C(=O)N(C)CCc2ccccc21>>CC(C)[C@H](O)C(=O)N[C@@H](C)C(=O)N[C@@H]1C(=O)N(C)CCc2ccccc21,,CC(C)O,,O,O,val
US20140171412A1,Cc1csc(-c2c3c(=O)n(C)c(=O)n(C)c3c3n2CC(CNC(=O)CCCBr)OC3c2ccc(Cl)o2)n1>>Cc1csc(-c2c3c(=O)n(C)c(=O)n(C)c3c3n2CC(CN2CCCC2=O)OC3c2ccc(Cl)o2)n1,,C1CCOC1,,[H-].[Na+],,val
US06248738B1,O=Cc1cccc2c(Cl)nccc12>>OCc1cccc2c(Cl)nccc12,,CO,,[BH4-].[Na+],,val
US20040110787A1,CCCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)sc21.CNCC(O)c1ccccn1>>CCCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN(C)CC(O)c3ccccn3)sc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20100035881A1,CCOC(=O)CCN.O=Cc1ccccc1>>O=C(O)CCNCc1ccccc1,,Cc1ccccc1,,Cl,,val
US05663354,Cn1nnc2ccc(CNNc3ccc(Cl)cc3)cc21>>Cn1nnc2ccc(CNNc3ccc(Cl)cc3)cc21,,ClCCl,O,Cl,[Na+].[OH-],val
US20130331397A1,COc1ccc(CN(Cc2ccc(OC)cc2)C(=O)c2cnn3ccc(N4C[C@@H](C#N)C[C@@H]4c4cccc(F)c4)cc23)cc1.OO>>COc1ccc(CN(Cc2ccc(OC)cc2)C(=O)c2cnn3ccc(N4C[C@@H](C(N)=O)C[C@@H]4c4cccc(F)c4)cc23)cc1,,CO,,[Na+].[OH-],,val
US20150065522A1,CCc1c(C(=O)O)[nH]c2c(-c3cnn(-c4ccccn4)c3)cnn2c1=O>>CCc1c(CO)[nH]c2c(-c3cnn(-c4ccccn4)c3)cnn2c1=O,,C1CCOC1,,,,val
US20090163524A1,COC(=O)C[C@H](NC(=O)C1(NC(=O)OC(C)(C)C)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1>>CC(C)(C)OC(=O)NC1(C(=O)N[C@@H](CCO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050176689A1,COC(=O)Cc1ccc(C#Cc2cc(O)c3c(c2)C(C)(C)CCC3=O)cc1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)Cc1ccc(C#Cc2cc(OS(=O)(=O)C(F)(F)F)c3c(c2)C(C)(C)CCC3=O)cc1,CN(C)c1ccncc1,CCCCCC,ClCCl,CCOC(C)=O,,val
US20140155427A1,COC(=O)c1ccc(CBr)cc1.O=Cc1ccc(O)cc1>>COC(=O)c1ccc(COc2ccc(C=O)cc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050234080A1,BrBr.CCCc1ncc(Cl)c(=O)n1Cc1ccccc1>>CCC(Br)c1ncc(Cl)c(=O)n1Cc1ccccc1,,CC(=O)O,,[Na+].[OH-],,val
US20110306618A1,CCOC(=O)C1CCC(Nc2nccc(-c3cnc4c(OCc5ccccc5)cccn34)n2)CC1.OC1CCNCC1>>O=C(C1CCC(Nc2nccc(-c3cnc4c(OCc5ccccc5)cccn34)n2)CC1)N1CCC(O)CC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20150264932A1,O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCN(CCO)c1ccccc1>>O=C1OCCN(c2ccccc2)CCO1,,C1CCOC1,,CCN(CC)CC,,val
US05175157,BrP(Br)Br.COc1ccc(CCN2CCCC(CO)C2)cc1OC>>COc1ccc(CCN2CCCC(CBr)C2)cc1OC,,ClC(Cl)(Cl)Cl,,O,[Na+].[OH-],val
US20140336207A1,COc1nsc(N)n1.O=C(Cl)Oc1ccccc1>>COc1nsc(NC(=O)Oc2ccccc2)n1,,ClCCl,,CCN(CC)CC,O,val
US20080221161A1,COC(=O)c1cc2ccc(OC)cc2nc1-c1ccsc1>>COc1ccc2cc(C(=O)O)c(-c3ccsc3)nc2c1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20110245257A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1cccnc1Nc1cc(F)cc(F)c1>>CC(NC(=O)OC(C)(C)C)c1nc2cccnc2n1-c1cc(F)cc(F)c1,,CC(=O)O,,O=C([O-])O.[Na+],,val
US20150274767A1,CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](n2ccc3c(NC(=O)c4ccccc4)nc(NC(=O)c4ccccc4)nc32)O[C@@H]1CO>>CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](n2ccc3c(NC(=O)c4ccccc4)nc(NC(=O)c4ccccc4)nc32)O[C@@H]1C=O,,CC#N,,,,val
US20090082358A1,O=C1c2ccccc2C(=O)N1/C=C/c1ccncc1C(O)c1ccc(C(F)(F)F)cc1>>O=C1c2ccccc2C(=O)N1CCc1ccncc1C(O)c1ccc(C(F)(F)F)cc1,[Pd],CO,,,,val
US07737166B2,COc1c(N)c(C(N)=O)c(C)c(I)c1Br.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COc1c(Br)c(I)c(C)c(C#N)c1NC(=O)C(F)(F)F,,C1CCOC1,,CCN(CC)CC,,val
US20150158846A1,C=CC(=O)Cl.CC(=O)OCc1c(-c2cc(Nc3cccc(OCCN)n3)c(=O)n(C)c2)ccnc1N1CCn2c(cc3c2CC(C)(C)C3)C1=O>>C=CC(=O)NCCOc1cccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3COC(C)=O)cn(C)c2=O)n1,,ClCCl,,,,val
US20150225400A1,CC(=O)Br.Cc1c[n+]([O-])c(C)cc1[N+](=O)[O-]>>Cc1c[n+]([O-])c(C)cc1Br,,CC(=O)O,,[Na+].[OH-],,val
US05616586,CS(=O)(=O)Cl.O=c1[nH]c2cc(Br)cc3c2n(c1=O)C(CO)CC3>>CS(=O)(=O)OCC1CCc2cc(Br)cc3[nH]c(=O)c(=O)n1c23,,C1CCOC1,O,CCN(CC)CC,Cl,val
US20070244092A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc[nH]n1>>CC(C)(C)OC(=O)Nc1cc[nH]n1,,C1CCOC1,,,,val
US20120058984A1,O=[N+]([O-])c1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@@H]4CC[C@@H](O)CC4)n3)sc2c1>>Nc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@@H]4CC[C@@H](O)CC4)n3)sc2c1,[Pd],C1CCOC1,,[H][H],,val
US20100168082A1,CC(C)(C)OC(=O)N1CCC(N(Cc2cc(Oc3ccc4c(ccn4C(=O)Nc4cccc(C(F)(F)F)c4)c3)ncn2)S(C)(=O)=O)C1>>CS(=O)(=O)N(Cc1cc(Oc2ccc3c(ccn3C(=O)Nc3cccc(C(F)(F)F)c3)c2)ncn1)C1CCNC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080275067A1,C1CCNCC1.CC(=O)OC(C)c1nc2cccc(C)c2c(=Nc2ccccc2)o1>>CC(=O)OC(C)C(=Nc1cccc(C)c1C(=O)Nc1ccccc1)N1CCCCC1,,CCOC(C)=O,,,,val
US20160152561A1,NS(=O)(=O)c1cccc(NC(=O)c2ccc(Cl)cc2F)c1.Oc1ccc(F)cc1Cl>>NS(=O)(=O)c1cccc(NC(=O)c2ccc(Cl)cc2Oc2ccc(F)cc2Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06833421B1,CCCCBr.COC(=O)/C=C/c1ccc(O)c(OC)c1>>CCCCOc1ccc(C=CC(=O)OC)cc1OC,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090247567A1,Brc1ccc2c(c1)-c1sc(-c3nnco3)cc1CCO2.Nc1ccc(C(F)(F)F)cc1Cl>>FC(F)(F)c1ccc(-n2cnnc2-c2cc3c(s2)-c2cc(Br)ccc2OCC3)c(Cl)c1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20100015178A1,NCCCNc1nonc1-c1noc(=O)n1-c1cccc(C(F)(F)F)c1.NS(N)(=O)=O>>NS(=O)(=O)NCCCNc1nonc1-c1noc(=O)n1-c1cccc(C(F)(F)F)c1,,c1ccncc1,,I,,val
US20020156081A1,CNC.COc1cc(-c2nn(CCOS(C)(=O)=O)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C>>COc1cc(-c2nn(CCN(C)C)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C,,CN(C)C=O,,CCN(CC)CC,[I-].[Na+],val
US20030055263A1,COc1cc2c(cc1OC)C(=O)OC2=O.Nc1nc(-c2ccc3ccccc3c2)cs1>>COc1cc(C(=O)O)c(C(=O)Nc2nc(-c3ccc4ccccc4c3)cs2)cc1OC,,c1ccncc1,,,,val
US20140212360A1,COCCOCCn1c2ccccc2c2cc(F)ccc21.O=C1CCC(=O)N1Br>>COCCOCCn1c2ccc(F)cc2c2cc(Br)ccc21,,ClC(Cl)Cl,,,,val
US20030018194A1,COC(=O)C1(C(C)=O)CC1.OCCO>>COC(=O)C1(C2(C)OCCO2)CC1,,O,c1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US05104888,Cc1c(C)c2c(c(C)c1O)C(=NOCC(=O)OC(C)(C)C)CC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2>>Cc1c(C)c2c(c(C)c1O)C(=NOCC(=O)O)CC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2,,C1COCCO1,,Cl,,val
US06083980,C=CCc1ccccc1CC.CO>>CCc1ccccc1CC=O,,ClCCl,,,,val
US20020052322A1,COC(=O)[C@@H](N)CC(C)C.C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O>>COC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)Cc1cc(F)cc(F)c1,,CO,ClC(Cl)Cl,Cl,,val
US20080167377A1,O=C(OCc1cccc(Cl)c1)c1cc(OCc2cccc(Cl)c2)ccc1Cl>>O=C(O)c1cc(OCc2cccc(Cl)c2)ccc1Cl,,C1COCCO1,O,[Li+].[OH-],,val
US20040138143A1,CON(C)C(=O)c1sc(C(C)C)cc1OCc1ccccc1.COc1ccc([Mg]Br)cc1>>COc1ccc(C(=O)c2sc(C(C)C)cc2OCc2ccccc2)cc1,,C1CCOC1,,,,val
US20080318960A1,NNC(=O)C(NC(=O)c1ccccc1)c1n[nH]c(=O)c2ccccc12.O=Cc1ccco1>>O=C(NC(C(=O)N/N=C/c1ccco1)c1n[nH]c(=O)c2ccccc12)c1ccccc1,,CCO,,CC(=O)O,,val
US20070021443A1,O=[N+]([O-])c1cnc(-n2cnc3ccc(F)cc32)nc1N[C@@H]1CCOc2c(F)cccc21>>Nc1cnc(-n2cnc3ccc(F)cc32)nc1N[C@@H]1CCOc2c(F)cccc21,[Pt],CCOC(C)=O,,,,val
US20100331312A1,O=C(CO)N1CCc2cc(-c3ccc(CCO)cc3)ccc2C1>>OCCc1ccc(-c2ccc3c(c2)CCNC3)cc1,,CO,,[Na+].[OH-],,val
US20020091265A1,Cc1ccccc1-c1ccncc1CO.FC(F)(F)c1cc(CBr)cc(C(F)(F)F)c1>>Cc1ccccc1-c1ccncc1COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CCCCCC,CN(C)C=O,[H-].[Na+],,val
US20040127552A1,CI.COc1cccc(SC[C@@H](C)CO)c1O>>COc1cccc(SC[C@@H](C)CO)c1OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100137278A1,Fc1nccnc1I.O=C1CCOCC1>>OC1(c2nccnc2F)CCOCC1,,C1CCOC1,,,,val
US20020045777A1,CCCNC.CN(C(=O)Oc1ccc(Cl)cc1)[C@@H]1CC[C@@H](C#CCOS(C)(=O)=O)CC1>>CCCN(C)CC#C[C@@H]1CC[C@@H](N(C)C(=O)Oc2ccc(Cl)cc2)CC1,,CC(=O)N(C)C,,,,val
US20050288290A1,COC(=O)c1cccoc1=O.Nc1cccnc1>>COC(=O)c1cccn(-c2cccnc2)c1=O,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20030158256A1,COC(=O)c1cc(C)ccc1F.O=C1CCC(=O)N1Br>>COC(=O)c1cc(CBr)ccc1F,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20080280875A1,CCOC(=O)c1cc(Oc2ccc(S(C)(=O)=O)cc2)c2cc(CC)oc2c1>>CCc1cc2c(Oc3ccc(S(C)(=O)=O)cc3)cc(C(=O)O)cc2o1,,CO,O,[K+].[OH-],,val
US20040009526A1,O=C1CSC(=O)N1.O=Cc1ccc(-c2cncc(C(=O)O)c2)o1>>O=C1NC(=O)C(=Cc2ccc(-c3cncc(C(=O)O)c3)o2)S1,C1CCNCC1,CCO,,,,val
US20120277208A1,CCOC(=O)c1noc(-c2ccc(Oc3cc(O[C@@H](C)COC)cc(C(=O)Nc4ccn(C)n4)c3)cn2)n1.N>>COC[C@H](C)Oc1cc(Oc2ccc(-c3nc(C(N)=O)no3)nc2)cc(C(=O)Nc2ccn(C)n2)c1,,C1CCOC1,,CO,,val
US20130209400A1,N#CCC(=O)ON1C(=O)CCC1=O.c1cn2ncc(-c3cncc(N[C@@H]4CCCNC4)n3)c2cn1>>N#CCC(=O)N1CCC[C@@H](Nc2cncc(-c3cnn4ccncc34)n2)C1,,ClCCl,,CCN(CC)CC,,val
US20130150361A1,O=C1CC[C@H](NC(=O)C(F)(F)F)c2ccccc21>>O=C(N[C@H]1CC[C@H](O)c2ccccc21)C(F)(F)F,,CN(C)C=O,,CCN(CC)CC,O=CO,val
US20110201580A1,CSCC(=O)[C@@]12CNC[C@@H]1C[C@H]1[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C.Clc1cccc(CBr)c1>>CSCC(=O)[C@@]12CN(Cc3cccc(Cl)c3)C[C@@H]1C[C@H]1[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C,,ClCCl,,Cl,,val
US20140206661A1,COc1cc2ncccc2cc1Cl.OO>>COc1cc2c(ccc[n+]2[O-])cc1Cl,O=[Mn]=O,ClCCl,,,,val
US20130018043A1,COC(=O)c1c(CN)c(=O)c2ccc(Cl)cc2n1-c1ccccc1.O=C(Cl)c1ccc(Cl)cc1>>COC(=O)c1c(CNC(=O)c2ccc(Cl)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US04296114,O=c1c(Cl)nc2ccccc2n1-c1ccc(Cl)cc1>>O=C1CNc2ccccc2N1c1ccc(Cl)cc1,[Zn],CC(=O)O,,,,val
US04304728,CC(=O)OCCl.O=C(O)c1oc(-c2ccccc2)cc(=O)c1Br>>CC(=O)OCOC(=O)c1oc(-c2ccccc2)cc(=O)c1Br,,CN(C)C=O,,CCN(CC)CC,,val
US20060019958A1,COc1ccc(Cl)cc1C=Cc1ccccc1>>Oc1ccc(Cl)cc1C=Cc1ccccc1,,CCOC(C)=O,ClCCl,BrB(Br)Br,,val
US04367238,CC=Cc1cc(Oc2ccccc2Cl)ccc1O.O=[O+][O-]>>O=Cc1cc(Oc2ccccc2Cl)ccc1O,,CC(=O)O,CCOC(C)=O,,,val
US20080207732A1,C1CN[C@H](CN2CCCC2)C1.CS(=O)(=O)c1cccc(Oc2ccc(C(=O)O)cc2)c1.O=C(Cl)C(=O)Cl>>CS(=O)(=O)c1cccc(Oc2ccc(C(=O)N3CCC[C@H]3CN3CCCC3)cc2)c1.Cl,CN(C)C=O,ClCCl,,CN1CCOCC1,,val
US20160122353A1,CC(C)NC(=O)c1cn(-c2cccnc2)nc1N.O=N[O-]>>CC(C)n1nnc2nn(-c3cccnc3)cc2c1=O,,Cl,O,O=C([O-])O.[Na+],,val
US20110144085A1,CC(C)(CO)[C@@H](O)CO.CC(C)=O>>CC1(C)OC[C@@H](C(C)(C)CO)O1,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05704948,O=C1CCCc2c1ccn2CC(O)CO>>OCC(O)Cn1ccc2c(O)cccc21,[Pd],COCCOCCOC,,O,,val
US20090306066A1,CC1(C)CN(C(=O)OCc2ccccc2)CC1=O.CON>>CO/N=C1\CN(C(=O)OCc2ccccc2)CC1(C)C,,CO,,Cl,CC(=O)[O-].[Na+],val
US20130065876A1,CN1CCN(NC(=O)OC(C)(C)C)CC1=O.O=C(O)C(F)(F)F>>CN1CCN(N)CC1=O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04435322,CCOC(=O)CCN(C(=O)CCl)C(C(=O)OCC)C(=O)OCC>>CCOC(=O)CCN1C(=O)CC1(C(=O)OCC)C(=O)OCC,,c1ccccc1,,CCN(CC)CC,Cl,val
US20010006969A1,CC(C)=CCN.Cc1csc2c(Cl)nc(Cl)nc12>>CC(C)=CCNc1nc(Cl)nc2c(C)csc12,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20150376192A1,CC(C)(C)C(=O)Cl.COc1ccc(Cn2ncc(C(N)=O)c2N)cc1>>COc1ccc(Cn2ncc(C(N)=O)c2NC(=O)C(C)(C)C)cc1,,C1CCOC1,CC(=O)N(C)C,c1ccncc1,,val
US20120232051A1,COCCBr.COc1cc(F)ccc1-c1ccncc1N(C)C(=O)c1cc(S)cc(C(F)(F)F)c1>>COCCSc1cc(C(=O)N(C)c2cnccc2-c2ccc(F)cc2OC)cc(C(F)(F)F)c1,,CC#N,CCOC(C)=O,CCN(C(C)C)C(C)C,[Cl-].[NH4+],val
US20130096118A1,CN(C)c1ccc(C(=O)Nc2cccc(C(C[N+](=O)[O-])c3c[nH]c4cc(N5CCOCC5)ccc34)c2F)cc1>>CN(C)c1ccc(C(=O)Nc2cccc(C(CN)c3c[nH]c4cc(N5CCOCC5)ccc34)c2F)cc1,[Ni],CO,,[H][H],,val
US20110230526A1,CC1(C)OB(c2cc(F)cc(C#N)c2)OC1(C)C.Cc1nc(C#Cc2ccc(Cl)nc2)cs1>>Cc1nc(C#Cc2ccc(-c3cc(F)cc(C#N)c3)nc2)cs1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,O=C([O-])[O-].[K+].[K+],,val
US08158650B2,COc1cc([C@@H](C)NC(C)=O)ccc1OC(C)=O.O=C1CCC(=O)N1Cl>>COc1cc([C@@H](C)NC(C)=O)c(Cl)cc1OC(C)=O,,CN(C)C=O,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20120040942A1,CC(=O)CC(=O)NCc1ccc(C(C)(C)C)cc1.Nc1ncc(I)cc1C=O>>Cc1nc2ncc(I)cc2cc1C(=O)NCc1ccc(C(C)(C)C)cc1,,CO,,C1CCNCC1,,val
US04801708,CN.CNn1c(SC)nnc(-c2ccccc2)c1=O>>CNc1nnc(-c2ccccc2)c(=O)n1NC,,CC(C)O,,,,val
US20070232583A1,CC(C)(C)NS(=O)(=O)c1cccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)c(F)c4)cc(C(F)(F)F)n3)c2)c1>>NS(=O)(=O)c1cccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)c(F)c4)cc(C(F)(F)F)n3)c2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040077712A1,CC1(C)COP(=O)(Cl)OC1c1ccc2ccccc2c1.[OH-]>>CC1(C)COP(=O)(O)OC1c1ccc2ccccc2c1,,O,,Cl,,val
US20130109662A1,C=C1CC(=O)O1.CC(C)CN>>CC(=O)CC(=O)NCC(C)C,,C1CCOC1,,,,val
US20100137281A1,CCc1cc(C(=O)OC)c(N)s1.COCCN.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCc1cc2c(=O)n(CCOC)c(=O)[nH]c2s1,,ClCCl,,CCN(CC)CC,,val
US20050267093A1,COc1cc(N)ccc1OCCN1CCC(C)CC1.O=C(O)C#Cc1ccc(C(F)(F)F)cc1Cl>>COc1cc(NC(=O)C#Cc2ccc(C(F)(F)F)cc2Cl)ccc1OCCN1CCC(C)CC1,,CO,ClCCl,,,val
US20090170790A1,O=C1c2ccccc2C(=O)N1CCCCBr.c1cnc2[nH]cnc2c1>>NCCCCn1cnc2cccnc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05495023,C/C=C(/C=C/CO)CC.O=C(Cl)c1cccnc1>>CC=C(C=CCOC(=O)c1cccnc1)CC,,ClCCl,,CCN(CC)CC,Cl,val
US20030069261A1,Fc1ccc(C2CCNCC2)cc1.O=C1NC(=O)c2c(CCCBr)cccc21>>O=C1NC(=O)c2c(CCCN3CCC(c4ccc(F)cc4)CC3)cccc21,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US04897387,CC(=O)O[C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@H]([C@H](C)[C@H](O)C#CC(C)(C)OC5CCCCO5)[C@@]4(C)CC[C@@H]3[C@@]2(C)[C@@H](OC(C)=O)C1.CCOC(C)=O>>CC(=O)O[C@H](CCC(C)(C)O)[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(C)=O)C[C@H](OC(C)=O)[C@]4(C)[C@H]3CC[C@]12C,[Pd],CCOC(C)=O,CO,C1CCOC1,Cl,val
US20050032786A1,O=C(OO)c1cccc(Cl)c1.O=C1c2ccccc2C(=O)N1Cc1ccccn1>>O=C1c2ccccc2C(=O)[N+]1([O-])Cc1ccccn1,,ClC(Cl)Cl,,,,val
US20130231328A1,CC(C)(C)OC(=O)NC1CCC(Oc2ncnc3sc4c(c23)C[C@H](CC(N)=O)CC4)CC1.Cl>>Cl.NC(=O)C[C@@H]1CCc2sc3ncnc(OC4CCC(N)CC4)c3c2C1,,ClCCl,,,,val
US20020156311A1,Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2cccc(OCCCO)c2)cc1.O=C1CCC(=O)N1Br>>Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2cccc(OCCCBr)c2)cc1,,CCOC(C)=O,CN(C)C=O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160060258A1,CC(C)(C)OC(=O)N1CCN(c2c(F)cc(Nc3ncc4c(=O)n(-c5c(Cl)cccc5Cl)ccc4n3)cc2F)CC1>>O=c1c2cnc(Nc3cc(F)c(N4CCNCC4)c(F)c3)nc2ccn1-c1c(Cl)cccc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130005707A1,C(=NC1CCCCNC1)c1ccccc1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCCCC(N=Cc2ccccc2)C1,,ClCCl,,CCN(CC)CC,O,val
US20050171115A1,CC(Cl)Cl.COc1ccc2cc(C=O)ccc2c1.OC1(C(CN2CCNCC2)c2cccc(Cl)c2)CCCCC1>>COc1ccc2cc(CN3CCN(CC(c4cccc(Cl)c4)C4(O)CCCCC4)CC3)ccc2c1.Cl.Cl,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070208040A1,CCOC(=O)c1sc2[nH]c(=O)n(CC)c(=O)c2c1C.CN>>CCn1c(=O)[nH]c2sc(C(=O)NC)c(C)c2c1=O,,CO,O,,,val
US20090156572A1,CC(C)(C)OC(=O)N1C[C@@H](C(=O)O)[C@H](c2ccc(Cl)c(Cl)c2)C1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N1C[C@@H](N)[C@H](c2ccc(Cl)c(Cl)c2)C1,,Cc1ccccc1,O,CCN(CC)CC,[Na+].[OH-],val
US05688803,CCOC(=O)c1c(-c2ccc(Cl)cc2N)[nH][nH]c1=O>>O=c1[nH][nH]c2c1c(O)nc1cc(Cl)ccc12,,CN(C)C=O,,,,val
US20060058305A1,CC(=O)OC(C)=O.Cc1cc(O)c2cc(-c3cccc(C(F)(F)F)c3)nnc2c1>>CC(=O)Oc1cc(C)cc2nnc(-c3cccc(C(F)(F)F)c3)cc12,,CCCCCC,CCOC(C)=O,c1ccncc1,,val
US20130324579A1,Cc1nc2ccccc2n1CCO.O=S(Cl)Cl>>Cc1nc2ccccc2n1CCCl,,ClCCl,,,,val
US20120141414A1,BrCCCCCCOC1CCCCO1.COC(=O)c1cccc(-c2cccc(O)c2)n1>>COC(=O)c1cccc(-c2cccc(OCCCCCCOC3CCCCO3)c2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130053382A1,C[Si](C)(C)CCOCn1ncc2cc(-c3ccc(C#N)nc3)c([N+](=O)[O-])cc21>>C[Si](C)(C)CCOCn1ncc2cc(-c3ccc(CN)nc3)c(N)cc21,[Pd],CC(=O)O,CCOC(C)=O,,,val
US20040058903A1,CC(=O)Nc1cccc(CCc2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)n1>>Nc1cccc(CCc2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)n1,,CO,,Cl,,val
US20060009453A1,CCOC(CNc1ccccc1)OCC.CNc1nccc(-c2cccnc2Oc2ccc(N)cc2)n1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CNc1nccc(-c2cccnc2Oc2ccc(-n3ccn(-c4ccccc4)c3=O)cc2)n1,,C1CCOC1,CCOC(C)=O,,,val
US20120046292A1,CC(C)(C)OC(=O)NCCN.ClCCl.O=C=Nc1ccccc1Cl>>Cl.NCCNC(=O)Nc1ccccc1Cl,,ClCCl,,CCN(CC)CC,,val
US06316389B1,C#CCCl.Cc1ccccc1O>>C#CCOc1ccccc1C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090163592A1,C=CC[Si@]1(Cl)OC(c2ccccc2)[C@@H](C)N1C.CC(C)(C)C=NNC(=O)OC(C)(C)C>>C=CC[C@H](NNC(=O)OC(C)(C)C)C(C)(C)C,,ClCCl,,,,val
US20150031727A1,COC(=O)c1ccc(CCc2ccc(NC(=O)c3c(N)sc4c3CCCC4)cc2)cc1.O=C(Cl)c1cccc(CCl)c1>>COC(=O)c1ccc(CCc2ccc(NC(=O)c3c(NC(=O)c4cccc(CCl)c4)sc4c3CCCC4)cc2)cc1,,ClCCl,,c1ccncc1,,val
US20120289505A1,COC(=O)[C@H](N)C(C)C.COC(=O)c1ccc(Br)cc1CBr>>COC(=O)[C@@H](C(C)C)N1Cc2cc(Br)ccc2C1=O,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,Cl,val
US20120225867A1,Cc1c(/C=N/O)ccc(C#N)c1Cl.O=C1CCC(=O)N1Cl>>Cc1c(/C(Cl)=N/O)ccc(C#N)c1Cl,,CN(C)C=O,,,,val
US06093718,CC(C)(C)OOC(=O)N1CCN(C(=O)C2CCN(S(=O)(=O)c3ccc(Cl)cc3)CC2)CC1.Cl>>Cl.O=C(C1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CCNCC1,,CCOC(C)=O,,,,val
US20140107151A1,CC(C)(C)C=C(C#N)C(=O)O.O=C(Cl)C(=O)Cl>>CC(C)(C)C=C(C#N)C(=O)Cl,CN(C)C=O,ClCCl,,,,val
US05110956,Cc1cc2c(cc1C(C)O)OCO2.O=C(O)CS>>Cc1cc2c(cc1C(C)SCC(=O)O)OCO2,,c1ccccc1,,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US04351977,CC1C=C2CCCCCCCCCC=C2C1>>CC1CC2=C(CCCCCCCCCC2)C1,[Pd],Cc1ccccc1,,,,val
US20090143361A1,CC(C)NC(=O)c1cccc(B(O)O)c1.COc1ccc2nc(C)c3c(C)nc(-c4cc(Cl)cc(Cl)c4)n3c2n1>>COc1ccc2nc(C)c3c(C)nc(-c4cccc(C(=O)NC(C)C)c4)n3c2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20120214762A1,COc1ncccc1N.Clc1cc(Cl)ncn1>>COc1ncccc1Nc1cc(Cl)ncn1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20140038957A1,CN(C(=O)OC(C)(C)C)C1CCNCC1.Cc1c[nH]c2ncnc(Cl)c12>>Cc1c[nH]c2ncnc(N3CCC(N(C)C(=O)OC(C)(C)C)CC3)c12,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20070244153A1,CC(C)[C@H](N)CNC(=O)c1cc2ccccc2o1.C[C@H](NC(=O)OC(C)(C)C)C(=O)O>>CC(C)[C@@H](CNC(=O)c1cc2ccccc2o1)NC(=O)[C@H](C)NC(=O)OC(C)(C)C,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20130065925A1,CC(C)(C)OC(=O)NC1CCN(CC2=CCCCC2)CC1>>NC1CCN(CC2=CCCCC2)CC1,,CO,,Cl,[Na+].[OH-],val
US20020183513A1,CCOC(=O)CCCCCOc1ccc2c(c1)[nH]c1ccccc12>>O=C(O)CCCCCOc1ccc2c(c1)[nH]c1ccccc12,,CO,,[Li+].[OH-],,val
US20100113444A1,CC1(C)CCC(C)(C)c2cc(CBr)ccc21.CCOC(=O)CNC(=O)c1c(O)n(C2CCCCC2)c(=O)[nH]c1=O>>CC1(C)CCC(C)(C)c2cc(Cn3c(=O)c(C(=O)NCC(=O)O)c(O)n(C4CCCCC4)c3=O)ccc21,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20050187228A1,Clc1nc(Cl)c2ncn(C3CCSC3)c2n1.NCc1ccccc1>>Clc1nc(NCc2ccccc2)c2ncn(C3CCSC3)c2n1,,CC(C)O,,CCCCO,,val
US06548494B1,CNC.O=C1C=CC2=CN=C(c3ccc(CCl)cc3)N3C[C@@H](CO)C(=C23)N1>>CN(C)Cc1ccc(C2=NC=C3C=CC(=O)NC4=C3N2C[C@H]4CO)cc1,,CC#N,,,,val
US20080039462A1,CN1CCC(=O)CC1.c1cc2cc(N3CCCC3)ccc2[nH]1>>CN1CC=C(c2c[nH]c3ccc(N4CCCC4)cc23)CC1,,CO,,[K+].[OH-],,val
US20120223634A1,COc1cccc(C(=N)Nc2ccccc2)c1.O=CCCl>>COc1cccc(-c2nccn2-c2ccccc2)c1,,CC(C)O,,O=C([O-])O.[Na+],,val
US20140005213A1,CC(C)(C)OC(=O)N[C@H]1CCN([C@H](c2ccc(NN)nc2)C(F)(F)F)C1.CC(C)Oc1cc2nc(C=O)ccc2cc1F>>CC(C)Oc1cc2nc(/C=N/Nc3ccc([C@@H](N4CC[C@H](NC(=O)OC(C)(C)C)C4)C(F)(F)F)cn3)ccc2cc1F,,CCO,,,,val
US05155268,CC(=O)c1ccccc1NS(C)(=O)=O.CI>>CC(=O)c1ccccc1N(C)S(C)(=O)=O,,C1CCOC1,CN(C)C=O,CCOC(C)=O,[H-].[Na+],val
US20050256158A1,CC(=O)N(C1CC1)C1CC(C)Nc2ccccc21.O=C(Cl)c1cccnc1>>CC(=O)N(C1CC1)C1CC(C)N(C(=O)c2cccnc2)c2ccccc21,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20050176689A1,COC(=O)Cc1ccc(C#Cc2cc(OC(C)C)c3c(c2)C(C)(C)CCC3N(C)C2CC2)cc1>>CC(C)Oc1cc(C#Cc2ccc(CC(=O)O)cc2)cc2c1C(N(C)C1CC1)CCC2(C)C,,C1CCOC1,CO,[Li+].[OH-],,val
US20100167934A1,Cc1ccc2c(c1)[C@H](Nc1ncc(C#C[Si](C)(C)C)c(N)n1)[C@@H](C)C2>>C#Cc1cnc(N[C@H]2c3cc(C)ccc3C[C@@H]2C)nc1N,,CO,O,[K+].[OH-],,val
US20080009488A1,CC(=O)c1cccc(Cl)c1C.NO>>C/C(=N/O)c1cccc(Cl)c1C,,CCO,,Cl,,val
US20140329820A1,Cc1nc(-c2ccccc2F)cn1NC(=O)OC(C)(C)C>>Cc1nc(-c2ccccc2F)cn1N,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20120108589A1,CC(=O)OC(C)=O.Cc1cn(-c2ccc(C(N)=O)c(N[C@@H]3CC[C@@H](N)CC3)c2)c2nccc(-c3cnc4ccccc4c3)c12>>CC(=O)N[C@@H]1CC[C@@H](Nc2cc(-n3cc(C)c4c(-c5cnc6ccccc6c5)ccnc43)ccc2C(N)=O)CC1,,ClCCl,,CCN(CC)CC,,val
US20080287479A1,COC(=O)c1cc2[nH]c(=O)n(C3CC[NH+](CC(=O)c4ccc(Cl)cc4)CC3)c2cc1F.[Cl-]>>COC(=O)c1cc2[nH]c(=O)n(C3CC[NH+](CC(O)c4ccc(Cl)cc4)CC3)c2cc1F.[Cl-],,CCO,CCOC(C)=O,[BH4-].[Na+],,val
US04028370,CN(C)c1nn2ccccc2c1C(N)=O>>CN(C)c1cc2ccccn2n1,,Cl,,,,val
US20110301143A1,CC(C)(C)OC(=O)N1CCC(C(=O)c2ccccc2Cl)CC1.Cl>>Cl.O=C(c1ccccc1Cl)C1CCNCC1,,CCOCC,,C1COCCO1,,val
US07547716B2,CC(=O)Nc1cccc2c(S(=O)(=O)Cl)cccc12.NCc1cccc2ccccc12>>CC(=O)Nc1cccc2c(S(=O)(=O)NCc3cccc4ccccc34)cccc12,,C1CCOC1,,CCN(CC)CC,Cl,val
US20050171110A1,BrCc1ccccc1.CCCCCC.CN(C)C=O.O=c1[nH][nH]c(=O)c(Cl)c1Cl>>O=c1c(Cl)c(Cl)c(OCc2ccccc2)nn1Cc1ccccc1,,CCCCCC,O,O=C([O-])[O-].[K+].[K+],,val
US20090088368A1,COC(=O)Cc1ccc(C)cc1.O=S(=O)(O)Cl>>COC(=O)Cc1ccc(C)c(S(=O)(=O)Cl)c1,,CCOC(C)=O,ClCCl,,,val
US20150216168A1,COC(=O)c1cccc([N+](=O)[O-])c1N.O=C(Cl)c1ccc(Br)c(F)c1>>COC(=O)c1cccc(NC(=O)c2ccc(Br)c(F)c2)c1N,,O,,C1CCOC1,CCN(CC)CC,val
US08829196B2,C=CCCCC1COCCC1=C>>C1=C2CCOCC2CCC1,,ClCCl,,,,val
US05260423,O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(C(F)(F)F)c1.SCc1ccccc1>>O=[N+]([O-])c1cc([N+](=O)[O-])c(SCc2ccccc2)c(C(F)(F)F)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04588722,CN=C=S.Fc1ccc(Cn2c(NC3CCN(C4CCCNC4)CC3)nc3ccccc32)cc1>>CNC(=S)N1CCCC(N2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)C1,,C1CCOC1,,,,val
US20120157428A1,Cc1noc(CN=[N+]=[N-])c1-c1cn(C)nc1C(=O)c1ccc(Cl)cc1>>Cc1noc2c1-c1cn(C)nc1C(c1ccc(Cl)cc1)=NC2,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130150359A1,COc1cc2ncc3c(c(-c4ccc(C#N)cc4F)nn3C)c2cc1O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1cc2ncc3c(c(-c4ccc(C#N)cc4F)nn3C)c2cc1OS(=O)(=O)C(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20050267146A1,COC(=O)C(C(=O)OC(C)(C)C)c1ncc(C(F)(F)F)cc1C#N>>CC(C)(C)OC(=O)C1C(=O)NCc2cc(C(F)(F)F)cnc21,[Ni],CCO,,[H][H],,val
US05861401,CN(C)c1cccc2c(S(=O)(=O)Cl)cccc12.Cc1nc(Br)cnc1N>>Cc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12,,COCCOC,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20130082209A1,O=P(Cl)(Cl)Cl.O=c1[nH]c2ccccc2c2nc3ccccc3n12>>Clc1nc2ccccc2c2nc3ccccc3n12,,O=P(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20080305081A1,C[C@H](NC(=O)OC(C)(C)C)c1ccc([C@H](O)CO)cc1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC[C@@H](O)c2ccc([C@H](C)NC(=O)OC(C)(C)C)cc2)cc1,,c1ccncc1,,O,,val
US20110082117A1,CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F.O=S(=O)(Nc1ncns1)c1ccc(N2CCNCC2)cc1>>C[C@H](C(=O)N1CCN(c2ccc(S(=O)(=O)Nc3ncns3)cc2)CC1)n1ccc2c(F)cccc21,,ClCCl,,,,val
US20090264400A1,Cc1cccc(Cl)c1S(=O)(=O)N(CCOCC(=O)O)C1CC1.Fc1cccc(C2(OCCN3CCCC3)CCNCC2)c1>>Cc1cccc(Cl)c1S(=O)(=O)N(CCOCC(=O)N1CCC(OCCN2CCCC2)(c2cccc(F)c2)CC1)C1CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05032598,Cl.O=C1c2ccccc2CC1C1CCNCC1.O=[N+]([O-])c1ccc(CCBr)cc1>>Cl.O=C1c2ccccc2CC1C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1,,CCO,,O=C([O-])O.[Na+],,val
US20120264735A1,Cn1cc(-n2ccc(=O)c(CO)n2)cn1.O=S(Cl)Cl>>Cn1cc(-n2ccc(=O)c(CCl)n2)cn1,,CC#N,,,,val
US20080085890A1,COC=C1C(=O)NC(=O)c2ccc(I)cc21.NCc1ccc(-c2ccccc2)c(O)c1>>O=C1NC(=O)c2ccc(I)cc2C1=CNCc1ccc(-c2ccccc2)c(O)c1,,CN(C)C=O,,,,val
US05177095,C=CCc1cc(C(=O)OC)ccc1O[Si](C)(C)C(C)(C)C>>C=CCc1cc(CO)ccc1O[Si](C)(C)C(C)(C)C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160176868A1,CCOC(=O)C(C#N)CC[C@@H](N[S@](=O)C(C)(C)C)c1cccc(OC)c1.Cl>>CCOC(=O)C(C#N)CC[C@@H](N)c1cccc(OC)c1.Cl,,C1COCCO1,CC#N,,,val
US20100029636A1,Cc1cc(Nc2ccc([N+](=O)[O-])cc2)n2ncc(-c3ccc(N4CCN(C)CC4)cc3)c2n1.Cl>>Cc1nc2c(-c3ccc(N4CCN(C)CC4)cc3)cnn2c(N)c1-c1ccc(N)cc1.Cl,,ClCCl,,CO,,val
US20160016903A1,CC(=O)OC(C)=O.CN(C)C1(Cc2ccccc2)CCC2(CCNC2)CC1>>CC(=O)N1CCC2(CCC(Cc3ccccc3)(N(C)C)CC2)C1,,ClCCl,,CCN(CC)CC,,val
US20140336377A1,CC(=O)OC(C)=O.CC(=O)c1cnc(OCC(F)(F)F)c(CO)c1>>CC(=O)OCc1cc(C(C)=O)cnc1OCC(F)(F)F,,ClCCl,,CCN(CC)CC,O,val
US20080019915A1,COC(=O)c1cc(O)cc(B2OC(C)(C)C(C)(C)O2)c1.Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1Cl>>COC(=O)c1cc(O)cc(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)ccc2C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US03953597,Nc1ncnc2c1ncn2Cc1c(Cl)cccc1Cl.OO>>Nc1c2ncn(Cc3c(Cl)cccc3Cl)c2nc[n+]1[O-],,CC(=O)O,,O,,val
US20130059834A1,CI.CS(=O)(=O)c1ccc2[nH]nc(I)c2c1>>Cn1nc(I)c2cc(S(C)(=O)=O)ccc21,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20100087427A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2Cc2ccccc2)C(C)C)ccc1C>>COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2Cc2ccccc2)C(C)C)ccc1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120115844A1,C[Si](C)(C)Cn1nnc(-c2ccccn2)c1CO>>Cn1nnc(-c2ccccn2)c1CO,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20080108608A1,CC(C)(C)c1cc(NC(=O)Nc2cccc(C#Cc3cnc(N)nc3)c2)no1.COCCOCC(=O)O>>COCCOCC(=O)Nc1ncc(C#Cc2cccc(NC(=O)Nc3cc(C(C)(C)C)on3)c2)cn1,,c1ccncc1,,O=P(Cl)(Cl)Cl,,val
US05374373,ClCc1ccccc1.Oc1ccc(Br)cc1F>>Fc1cc(Br)ccc1OCc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090156804A1,CC(Cl)Cl.Fc1ccc([C@H]2CN(Cc3ccccc3)CCO2)cc1>>Cl.Fc1ccc([C@H]2CNCCO2)cc1,,CC(Cl)Cl,,CC(Cl)OC(=O)Cl,,val
US05550130,O=C1c2ccccc2C(=O)N1CCN1CCC(c2noc3cc(F)ccc23)CC1>>O=C1c2ccccc2C(O)N1CCN1CCC(c2noc3cc(F)ccc23)CC1,,CO,ClCCl,[BH4-].[Na+],,val
US20100048502A1,COCOc1ccc2ccc(COC(C)=O)nc2c1Cl>>CC(=O)OCc1ccc2ccc(O)c(Cl)c2n1,Cl,CO,,,,val
US04560683,CC(=O)OC(C)OC(=O)C1=C(COC(N)=O)CS[C@@H]2[C@H](NC(=O)/C(=N\OCC3CC3)c3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)C(=O)N12>>CC(=O)OC(C)OC(=O)C1=C(COC(N)=O)CS[C@@H]2[C@H](NC(=O)/C(=N\OCC3CC3)c3csc(N)n3)C(=O)N12,,O=CO,,O,,val
US20080076813A1,N#Cc1ccc(N2C(=O)C(CC(=O)O)=C3CCCCC32)cc1>>N#Cc1ccc(N2C(=O)C(CCO)=C3CCCCC32)cc1,,C1CCOC1,CCOC(C)=O,N#N,,val
US20050191527A1,Clc1cnc2ccccc2n1.OB(O)c1cc(F)cc(F)c1>>Fc1cc(F)cc(-c2cnc3ccccc3n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20150232481A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc(C=CCc3ccc(F)cc3O)nn2c1N1CCC(C)(OCCCC[C@@H](C)O)CC1>>Cc1nc2cc3nn2c(c1[C@H](OC(C)(C)C)C(=O)O)N1CCC(C)(CC1)OCCCC[C@H](C)Oc1cc(F)ccc1CC=C3,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110160255A1,Cn1nccc1-c1nc(C(=O)O)cs1.N[C@@H](Cc1cccc(F)c1)CN1C(=O)c2ccccc2C1=O>>Cn1nccc1-c1nc(C(=O)N[C@@H](Cc2cccc(F)c2)CN2C(=O)c3ccccc3C2=O)cs1,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20140329798A1,CCc1cnc(N2CCC([C@H]3C[C@H]3CCO)CC2)nc1.O=C(Cc1c(F)cc(O)cc1F)N1CCC1>>CCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3cc(F)c(CC(=O)N4CCC4)c(F)c3)CC2)nc1,,ClCCl,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04497808,CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1cccc(C)[n+]1[O-].CCOC(=O)CC(C)=O>>Cc1cccc(C=O)[n+]1[O-],,CCO,,N,,val
US20070197537A1,Cn1c(Cl)ncc(Br)c1=O.NCc1ccccc1>>Cn1c(NCc2ccccc2)ncc(Br)c1=O,,CCCCO,CCOC(C)=O,O=C([O-])O.[Na+],,val
US20100305133A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc(-c2cc3nccnc3c(C(=O)NCC(=O)O)c2O)c1>>O=C(O)CNC(=O)c1c(O)c(-c2cc[nH]c2)cc2nccnc12,,CCO,,[Na+].[OH-],,val
US09034851B2,CCOP(C)(=O)c1cnn(-c2ncc(C(=O)NC(c3ccccc3)c3ccccc3)c(O)n2)c1>>CP(=O)(O)c1cnn(-c2ncc(C(=O)NC(c3ccccc3)c3ccccc3)c(O)n2)c1,,C1COCCO1,O,[Na+].[OH-],,val
US20150018422A1,CCOC(=O)CP(=O)(OCC)OCC.COCOCc1cc(C(=O)C2CC2)ccn1>>CCOC(=O)C=C(c1ccnc(COCOC)c1)C1CC1,,C1CCOC1,,O,[H-].[Na+],val
US20110245205A1,CC(=O)Cl.CC(C)(c1ncc(-c2cc(N)cc(Nc3nccc(C(F)(F)F)n3)c2)s1)S(N)(=O)=O>>CC(=O)Nc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C(C)(C)S(N)(=O)=O)s2)c1,,CO,ClCCl,CCN(CC)CC,,val
US20050228155A1,C1=CC(=C(c2ccccc2)c2ccccc2)C=C1c1ccccc1.CC1(C)CCC(C)(C)c2cc3c(cc21)Cc1cc2c(cc1-3)C(C)(C)CCC2(C)C>>CC1(C)CCC(C)(C)c2cc3c(cc21)Cc1cc2c(cc1-3)C(C)(C)CC(C(c1ccccc1)(c1ccccc1)C1C=CC(c3ccccc3)=C1)C2(C)C,,C1CCOC1,O,CCCCCC,[Li]CCCC,val
US04200641,O=S(Cl)Cl.OCCCn1c(Cc2ccccc2)nc2cc(Cl)ccc21>>ClCCCn1c(Cc2ccccc2)nc2cc(Cl)ccc21,,ClC(Cl)Cl,,,,val
US20100010035A1,COc1nc(C)cnc1N(C(=O)NOCC(C)C)S(=O)(=O)c1sccc1Br.O=Cc1ccc(B(O)O)cc1>>COc1nc(C)cnc1N(C(=O)NOCC(C)C)S(=O)(=O)c1sccc1-c1ccc(C=O)cc1,,CCO,Cc1ccccc1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20120010247A1,CC(=O)CBr.COCOc1cc(O)c(C=O)cc1Cl>>COCOc1cc2oc(C(C)=O)cc2cc1Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05132310,C#CC1(C)CCc2c(C)c(O)c(C)c(C)c2O1.Ic1ccccc1>>Cc1c(C)c2c(c(C)c1O)CCC(C)(C#Cc1ccccc1)O2,,CC#N,,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05624943,COC(=O)c1cncc(C#C[Si](C)(C)C)c1>>C#Cc1cncc(C(=O)OC)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110003787A1,COC(=O)c1cnc(O)cn1.ClC(Cl)Cl>>COC(=O)c1cnc(Cl)cn1,CN(C)C=O,,,,,val
US20080153905A1,CC(=O)OC(C)=O.N#CC(CO)c1ccccc1>>CC(=O)OCC(C#N)c1ccccc1,,CC#N,,O=S(=O)(O)O,,val
US05385880,COC(=O)c1ccc(C)nc1O.COc1cc(OC)nc(Cl)n1>>COC(=O)c1ccc(C)nc1Oc1nc(OC)cc(OC)n1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090247559A1,CCOC(=O)c1cnc2cc(C3CCN(C(=O)OC(C)(C)C)CC3)nn2c1>>CC(C)(C)OC(=O)N1CCC(c2cc3ncc(C(=O)O)cn3n2)CC1,,CO,,Cl,[Na+].[OH-],val
US20150065343A1,Cc1cc(/C=C/C(=O)NC(c2cccc(C(F)(F)F)c2)C(F)(F)F)sc1C=O>>Cc1cc(/C=C/C(=O)NC(c2cccc(C(F)(F)F)c2)C(F)(F)F)sc1CO,,CO,,[BH4-].[Na+],,val
US20100016306A1,CN(C)C(=O)C(C)(C)N1CCNCC1.Clc1nc(N2CCOCC2)c2sc(CBr)cc2n1>>CN(C)C(=O)C(C)(C)N1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05462944,CC(C)(C)C1CCC(=O)CC1.Cc1cc(C)nc(NCC(O)CO)n1>>Cc1cc(C)nc(NCC2COC3(CCC(C(C)(C)C)CC3)O2)n1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20160159795A1,CCOC(=O)/C=C1\NCCc2c(I)cccc21.CCOC(=O)CC1NCCc2c(I)cccc21>>O=C1C=C2c3cccc(I)c3CCN2C(=O)CN1,,CC(=O)O,CCO,[BH3-]C#N.[Na+],,val
US20150087646A1,COC(=O)c1ccc(-n2nc(-c3c(Cl)cccc3Cl)[nH]c2=O)cc1OC.Nc1ccc(C(F)(F)F)cc1N>>COc1cc(-n2nc(-c3c(Cl)cccc3Cl)[nH]c2=O)ccc1-c1nc2cc(C(F)(F)F)ccc2[nH]1,,Cc1ccccc1,,C[Al](C)C,,val
US20110183982A1,CCOC(=O)COc1ccc(Sc2cc(C#CCOC)cc(OCCCN3CCOCC3)c2)c(Cl)c1>>COCC#Cc1cc(OCCCN2CCOCC2)cc(Sc2ccc(OCC(=O)O)c(Cl)c2)c1,,CCO,,Cl,[Na+].[OH-],val
US20150065519A1,NC(=S)c1ccnc(N)c1.O=C(CBr)c1ccc(NS(=O)(=O)C(F)(F)F)cc1Cl>>Nc1cc(-c2ncc(-c3ccc(NS(=O)(=O)C(F)(F)F)cc3Cl)s2)ccn1,,CCO,,,,val
US20150038438A1,Cn1c(CO[Si](C)(C)C(C)(C)C)cc2cc3c(cc21)N(C(=O)OC(C)(C)C)CCC=CC3O>>Cn1c(CO[Si](C)(C)C(C)(C)C)cc2cc3c(cc21)N(C(=O)OC(C)(C)C)CCC=CC3=O,O=[Mn]=O,,,,,val
US06255327B1,Cc1nc(-c2ccccc2)nn1-c1ccccc1OCc1ccccc1>>Cc1nc(-c2ccccc2)nn1-c1ccccc1O,,ClCCl,,BrB(Br)Br,,val
US20090209607A1,Cn1nccc1-c1coc(C(=O)O)c1.N[C@@H](Cc1ccccc1C(F)(F)F)CN1C(=O)c2ccccc2C1=O>>Cn1nccc1-c1coc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)c1,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US09447091B2,CN(C)S(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1>>CNS(=O)(=O)N(C)c1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1,,ClCCl,,c1ccncc1,,val
US20080249091A1,CCOC(=O)c1c(Cl)c2cc(C(=O)c3ccc(OC(F)(F)F)cc3)ccc2n1-c1ccc(OC2CCCC2)cc1>>O=C(c1ccc(OC(F)(F)F)cc1)c1ccc2c(c1)c(Cl)c(C(=O)O)n2-c1ccc(OC2CCCC2)cc1,O,C1COCCO1,,Cl,[Na+].[OH-],val
US20080058389A1,CC(C)SC(C)c1ccccc1[N+](=O)[O-]>>CC(C)SC(C)c1ccccc1N,[Ni],CCO,,[H][H],,val
US20090004137A1,C[Si](C)(C)C#Cc1cn(C2CC(O)C(COC(c3ccccc3)(c3ccccc3)c3ccccc3)O2)c(=O)[nH]c1=O>>C#Cc1cn(C2CC(O)C(COC(c3ccccc3)(c3ccccc3)c3ccccc3)O2)c(=O)[nH]c1=O,,CC#N,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20020160996A1,Cc1c(C)c2c(c(C)c1N)C(c1ccc(C(C)C)cc1)C(C)(C)O2.O=C(Cl)c1ccc2c(c1)OCO2>>Cc1c(C)c2c(c(C)c1NC(=O)c1ccc3c(c1)OCO3)C(c1ccc(C(C)C)cc1)C(C)(C)O2,,CCCCCC,CCOCC,,,val
US20140162983A1,CN1CCCC1=O.NCc1ccc(-c2cnccc2Oc2ccc(Oc3ccccc3)cc2)cc1>>CCC(=O)NCc1ccc(-c2cnccc2Oc2ccc(Oc3ccccc3)cc2)cc1,,ClCCl,,c1ccncc1,,val
US20110098425A1,CC(C)(C)c1cccc(C=O)c1O.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)c1cccc(C=O)c1OCc1ccccc1,,ClCCl,,,,val
US06187923B1,C1COCCO1.Cc1cccc(N)c1C(=O)O.O=C(Cl)Cl>>COc1cccc2c(=O)oc(=O)[nH]c12,,Cc1ccccc1,,,,val
US06048882,CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CBr.NCc1ccc2c(c1)OCO2>>CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CNCc1ccc2c(c1)OCO2,,C1CCOC1,,O,,val
US20150232459A1,COC(=O)NC/C=C/B1OC(C)(C)C(C)(C)O1.CON(C)C(=O)c1cc(Br)nc(C(F)(F)F)c1>>COC(=O)NC/C=C/c1cc(C(=O)N(C)OC)cc(C(F)(F)F)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US04496572,BrBr.COC(=O)c1ccc2sc(C)cc2c1>>COC(=O)c1ccc2sc(C)c(Br)c2c1,,ClC(Cl)Cl,,CC(=O)[O-].[Na+],,val
US20140142083A1,CI.COC(=O)c1cc(Cl)cc(NC2CCCC2)c1Cl>>COC(=O)c1cc(Cl)cc(N(C)C2CCCC2)c1Cl,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120149691A1,CC1CCCCC1Nc1c(C(N)=O)cnn2c(NC(=O)OC(C)(C)C)ccc12.O=C(O)C(F)(F)F>>CC1CCCCC1Nc1c(C(N)=O)cnn2c(NC(=O)C(F)(F)F)ccc12,,ClCCl,,,,val
US20110312905A1,Cc1c(O)c(=O)ccn1C.O=S(=O)(Cl)c1ccccc1>>Cc1c(OS(=O)(=O)c2ccccc2)c(=O)ccn1C,,c1ccncc1,,,,val
US04550166,Brc1ncccc1-c1cccnc1.NN>>NNc1ncccc1-c1cccnc1,,c1ccncc1,,,,val
US20100022546A1,COCCCN.O=C(NC12CC3CC(C1)CC(NC(=O)c1cccc(Cl)n1)(C3)C2)c1ccccn1>>COCCCNc1cccc(C(=O)NC23CC4CC(CC(NC(=O)c5ccccn5)(C4)C2)C3)n1,O=[Cu],CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130178443A1,Nc1nc(C(=O)N2Cc3ccccc3C2)c2cc(-c3cc(F)ccc3CO)ccc2n1.O=S(Cl)Cl>>Nc1nc(C(=O)N2Cc3ccccc3C2)c2cc(-c3cc(F)ccc3CCl)ccc2n1,,ClCCl,,,,val
US20110130415A1,Cn1nnn(-c2cccc([N+](=O)[O-])c2)c1=O>>Cn1nnn(-c2cccc(N)c2)c1=O,[Pd],CO,,CCOC(C)=O,,val
US20060004087A1,CC(=O)OC(C)=O.COc1ccc2c(c1)CCCC(Br)C2=O>>COc1ccc2c(c1)CCCC(Br)=C2OC(C)=O,,C1CCOC1,CCOCC,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20080090822A1,CC(=O)c1ccc(N2CCNCC2)c(F)c1.CS(=O)(=O)c1ccc(N2CCCCC2)c(C(=O)O)c1>>CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3N3CCCCC3)CC2)c(F)c1,,CCN(CC)CC,,ClCCCl,,val
US20160228450A1,CCCOc1ccc(Br)cc1.O=C1CCN(Cc2ccccc2)CC1>>CCCOc1ccc(C2(O)CCN(Cc3ccccc3)CC2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20030008849A1,CCOC(=O)CNS(=O)(=O)c1ccc(F)cc1.CI>>CCOC(=O)CN(C)S(=O)(=O)c1ccc(F)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04182760,Nc1ccc(Cl)cc1C(=NO)c1ccccc1.O=C(Cl)C(F)Cl>>O=C(Nc1ccc(Cl)cc1C(=NO)c1ccccc1)C(F)Cl,,O,,CCOCC,,val
US20050049257A1,CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1O.CCc1nc(NC2CCOc3ccccc32)c(CC)nc1Br.Cc1ccc(B(O)O)c(Cl)c1>>CCc1nc(-c2ccc(C)cc2Cl)c(CC)nc1NC1CCOc2ccccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,,,val
US20040106604A1,NN=C(c1ccccc1)c1ccccc1.O=C(Cl)CCCCl>>O=C(CCCCl)NN=C(c1ccccc1)c1ccccc1,,ClCCl,,O,c1ccncc1,val
US20040102450A1,COC(=O)C1CN(Cc2cc3cc(Cl)ccc3n2C(=O)OC(C)(C)C)CC(=O)N1Cc1ccc2c(N)ncnc2c1>>COC(=O)C1CN(Cc2cc3cc(Cl)ccc3[nH]2)CC(=O)N1Cc1ccc2c(N)ncnc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110076292A1,CC(C)NN.CN(C)C=NC(=O)c1cn2c(n1)-c1cc(Cl)ncc1OCC2>>CC(C)n1ncnc1-c1cn2c(n1)-c1cc(Cl)ncc1OCC2,,CC(=O)O,,Cl,,val
US20110009381A1,CC(Br)Br.CCOC(=O)c1cc(O)cc(-c2ccccc2)n1>>CCOC(=O)c1cc(OCCBr)cc(-c2ccccc2)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05688798,Cc1ncc(CCl)c(N)n1.c1ccc(CCN2CCNCC2)cc1>>Cc1ncc(CN2CCN(CCc3ccccc3)CC2)c(N)n1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20140187581A1,COC(=O)c1nn(C(C)C)c2ccccc12.NN>>CC(C)n1nc(C(=O)NN)c2ccccc21,,CCO,,O,,val
US20090149441A1,O=C(Nc1ccccc1)c1cn2cc(I)ccc2n1.OB(O)c1ccccc1>>O=C(Nc1ccccc1)c1cn2cc(-c3ccccc3)ccc2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CC#N,O=C([O-])[O-].[Na+].[Na+],val
US03993679,Cc1cc([N+](=O)[O-])c(Cl)c([N+](=O)[O-])c1>>Cc1cc(N)c(Cl)c(N)c1,,CCO,,Cl,[Na+].[OH-],val
US20120165318A1,COC(=O)c1ccc2nc(-c3ccccc3)c(N3CC[C@@H](O)C3)nc2c1>>O=C(O)c1ccc2nc(-c3ccccc3)c(N3CC[C@@H](O)C3)nc2c1,,CO,O,Cl,[Na+].[OH-],val
US20050197350A1,CS(=O)(=O)O.Cc1cc(N[C@@H]2CC[C@H](NC(=O)c3ccc(F)c(F)c3)CC2)nc2ccccc12>>CS(=O)(=O)O.Cc1cc(N[C@@H]2CC[C@H](NC(=O)c3ccc(F)c(F)c3)CC2)nc2ccccc12,,CCO,,,,val
US20140148433A1,CC(C)n1c(=O)[nH]c2nc(-c3nn(Cc4ccccc4F)c4ncccc34)nc(I)c21>>CC(C)n1c(=O)[nH]c2nc(-c3nn(Cc4ccccc4F)c4ncccc34)ncc21,[Pd],CN(C)C=O,,[H][H],,val
US20080058515A1,COc1cc([N+](=O)[O-])ccc1OCCBr>>COc1cc(N)ccc1OCCBr,[Pd],CO,,[H][H],,val
US05589473,CC(C)(C)[Si](C)(C)Cl.COc1cc(O)c(C)c(C(=O)O)c1Br>>COc1cc(O[Si](C)(C)C(C)(C)C)c(C)c(C(=O)O)c1Br,,CC#N,,CCN(CC)CC,,val
US04965270,CN(C)C=NO[C@H](CCOCc1ccccc1)COCc1ccccc1.N#CC(N)C(N)=O>>N#C[C@@H](NC=NOC(CCOCc1ccccc1)COCc1ccccc1)C(N)=O,,CO,,Cl,,val
US04005217,C[C@H]1CNC[C@@H](C)O1.O=C(CCl)Nc1ccccc1[N+](=O)[O-]>>C[C@H]1CN(CC(=O)Nc2ccccc2[N+](=O)[O-])C[C@@H](C)O1,,CCO,,,,val
US05175290,CCCn1c(N)cc(=O)[nH]c1=O.CCOC(=O)CBr>>CCCn1c(N)cc(=O)n(CC(=O)OCC)c1=O,,O,,[H][H],[H-].[Na+],val
US20090215750A1,CC(C)(C)C(=O)c1c[nH]c2ncc(-c3ccc(C(=O)O)s3)nc12.CNCC#N>>CN(CC#N)C(=O)c1ccc(-c2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)s1,,CCO,ClCCl,CCN=C=NCCCN(C)C,,val
US20140080808A1,CN(C)C(=O)c1ccc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO[Si](C)(C)C(C)(C)C)C5)CC3)cc2)cn1>>CN(C)C(=O)c1ccc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO)C5)CC3)cc2)cn1,,CO,,Cl,,val
US05177096,CCCCc1ncc[nH]1.Fc1cccc(Cl)c1CCl>>CCCCc1nccn1Cc1c(F)cccc1Cl,,CN(C)C=O,,[H-].[Na+],,val
US20160185751A1,C.CC#N.[N-]=[N+]=NCCCCl>>ClCCCn1ccnn1,I[Cu]I,O,,O=C(CO)O[CH][C@@H](O)CO,C[O-].[Na+],val
US20140080798A1,C=O.NC(=O)Cc1cc(F)ccc1CCc1nc(Nc2ccc(C3CCNCC3)cc2)ncc1C(F)(F)F>>CN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccc(F)cc4CC(N)=O)n3)cc2)CC1,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
USRE029607,CCOC(=O)[O-].OCC(O)CNc1cccc(C(F)(F)F)c1>>O=C1OC(CO)CN1c1cccc(C(F)(F)F)c1,,CO,,C[O-].[Na+],,val
US04242355,COc1cccc(CC(=O)O)c1.NCCc1c[nH]c2ccccc12>>COc1cccc(CC(=O)NCCc2c[nH]c3ccccc23)c1,,CCOC(C)=O,,,,val
US08252803B2,Cc1ccc(C(C)(C)C)cc1Nc1nc(Cl)ncc1F.c1cn(C2CCNCC2)nn1>>Cc1ccc(C(C)(C)C)cc1Nc1nc(N2CCC(n3ccnn3)CC2)ncc1F,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20140315881A1,Cc1ccc(Br)c(C)c1.O=C1CCOCC1>>Cc1ccc(C2(O)CCOCC2)c(C)c1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US09156827B2,CC(C)(C)OC(=O)N1CCN(Cc2c(OCc3ccccc3)ccc3c2O/C(=C\c2c[nH]c4ccccc24)C3=O)CC1>>O=C1/C(=C/c2c[nH]c3ccccc23)Oc2c1ccc(OCc1ccccc1)c2CN1CCNCC1,,C1COCCO1,ClCCl,Cl,,val
US20060205718A1,CC(C)(CO)CBr.CCOc1cc(O)cc(CO)c1>>CCOc1cc(CO)cc(OCC(C)(C)CO)c1,,CN(C)C=O,O,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20150126485A1,CC1(O)CNC1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(-c2ncc[nH]2)c1>>CC1(O)CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ncc[nH]2)C1,,CC(C)O,,CCN(C(C)C)C(C)C,Cl,val
US20090239864A1,CC(=O)N1CCC(O)CC1.Oc1ccc([C@H]2CN(Cc3ccccc3)CCO2)cc1>>CC(=O)N1CCC(Oc2ccc([C@H]3CN(Cc4ccccc4)CCO3)cc2)CC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090131510A1,Fc1cccc2c1C1(c3ccc(OCc4ccccc4)cc3)CCCCC=C1O2>>Oc1ccc(C23CCCCC=C2Oc2cccc(F)c23)cc1,[Pd],CCO,CCOC(C)=O,,,val
US20030171377A1,COC(=O)C(Cc1cccc2c(CCCc3nc(-c4ccccc4)oc3C)cccc12)n1cccc1>>Cc1oc(-c2ccccc2)nc1CCCc1cccc2c(CC(C(=O)O)n3cccc3)cccc12,,CO,O,[Li+].[OH-],,val
US20030125371A1,BrCc1ccccc1.Brc1ccc2cc[nH]c2c1>>Brc1ccc2ccn(Cc3ccccc3)c2c1,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20060052374A1,Nc1cccc(C(F)(F)F)c1F.S=C(Cl)Cl>>Fc1c(N=C=S)cccc1C(F)(F)F,,ClCCl,O,O=C([O-])O.[Na+],,val
US20020049242A1,BrBr.CCOC(=O)c1sc(SC)c2c1CCCC2=O>>CCOC(=O)c1sc(SC)c2c1CCC(Br)C2=O,,ClC(Cl)Cl,,,,val
US20120157461A1,CN1CC(=O)N2[C@@H](Cc3cc(O)c(O)cc3[C@H]2c2cn(C(=O)OC(C)(C)C)c3ccccc23)C1=O.ClCBr>>CN1CC(=O)N2[C@@H](Cc3cc4c(cc3[C@H]2c2c[nH]c3ccccc23)OCO4)C1=O,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20060160865A1,CN(C(=O)Oc1ccc(N)cn1)c1ccccc1.O=C(Cl)c1cccc(C(F)(F)F)c1F>>CN(C(=O)Oc1ccc(NC(=O)c2cccc(C(F)(F)F)c2F)cn1)c1ccccc1,,CC#N,,CCN(CC)CC,ClCCl,val
US20140329797A1,CC(C)(c1ccc(-c2noc(-c3ccc(=O)n(Cc4cccc(C(=O)Cl)c4)n3)n2)cc1)C(F)(F)F.CN>>CNC(=O)c1cccc(Cn2nc(-c3nc(-c4ccc(C(C)(C)C(F)(F)F)cc4)no3)ccc2=O)c1,,C1CCOC1,ClCCl,,,val
US20080182874A1,CCOC(=O)CC1CCNCC1.O=C(NCC12CC3CC(CC(C3)C1)C2)c1c(Cl)ccc2nc(Cl)ccc12>>O=C(O)CC1CCN(c2ccc3c(C(=O)NCC45CC6CC(CC(C6)C4)C5)c(Cl)ccc3n2)CC1,,CC#N,,CCN(CC)CC,,val
US04992454,CC(n1cncn1)C1(c2ccc(F)cc2F)CO1.c1nc[nH]n1>>CC(n1cncn1)C(O)(Cn1cncn1)c1ccc(F)cc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06093732,C[Si](C)(C)CCOCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(F)c(F)c(F)c21.OCc1ccc(O)cc1>>O=C(NCc1ccc(Cl)cc1)c1cnc2c(F)c(Oc3ccc(CO)cc3)c(F)cc2c1O,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US04105776,CC(CS)C(=O)O.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(CSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)O,,ClCCl,,,,val
US06380256B1,CCOC1(c2ccc(C#C[Si](C)(C)C)cc2C(C)C)CC1>>C#Cc1ccc(C2(OCC)CC2)c(C(=C)C)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20040082607A1,CC(C)Cn1c(CCl)c(-c2ccc(F)cc2)c2cc(OCc3ccccc3)ccc2c1=O.O=C1NC(=O)c2ccccc21>>CC(C)Cn1c(CN2C(=O)c3ccccc3C2=O)c(-c2ccc(F)cc2)c2cc(OCc3ccccc3)ccc2c1=O,,CN(C)C=O,,O,[K],val
US05786364,CN1CCc2ccc([N+](=O)[O-])cc2C1.Cl>>CN1CCc2ccc(N)cc2C1.Cl,[Pd],CCO,,CCOCC,,val
US20090088459A1,BrCC1CC1.CS(=O)(=O)c1cccc(-c2ccc(CNS(=O)(=O)c3ccccc3C(F)(F)F)s2)c1>>CS(=O)(=O)c1cccc(-c2ccc(CN(CC3CC3)S(=O)(=O)c3ccccc3C(F)(F)F)s2)c1,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06184379B2,Br.CCN1c2cc(OC)ccc2C(C)=CC1(C)C>>Br.CCN1c2cc(O)ccc2C(C)=CC1(C)C,,CC(=O)O,,,,val
US20130197059A1,CCOC(=O)c1c(C)nc(Cl)nc1C.COc1cccc(CCCN)c1>>CCOC(=O)c1c(C)nc(NCCCc2cccc(OC)c2)nc1C,,CCO,,,,val
US20040097563A1,Nc1cccc(-c2cc(-c3ccccc3O)nc(N)c2CO)c1.O=C(Cl)CCCl>>Nc1nc(-c2ccccc2O)cc(-c2cccc(NC(=O)CCCl)c2)c1CO,,C1CCOC1,O,c1ccncc1,,val
US06339090B1,COC(=O)C1=C(C)NC(=O)N(C)C1c1ccc(F)c(F)c1>>CC1=C(C(=O)O)C(c2ccc(F)c(F)c2)N(C)C(=O)N1,,CO,,[Na+].[OH-],,val
US20160096827A1,N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@H]1CCNCC1(F)F.O=C1N[C@H](C(=O)O)CS1>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@H]1CCN(C(=O)[C@@H]2CSC(=O)N2)CC1(F)F,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070219210A1,CCOC(=O)c1cc(-c2ccc(OCc3ccccc3)cn2)n(-c2ccccc2)n1>>CCOC(=O)c1cc(-c2ccc(O)cn2)n(-c2ccccc2)n1,[Pd],CCO,CCOC(C)=O,,,val
US20070238718A1,CC(=O)Nc1nc2c(s1)C(=O)C(C(=O)C1CC1)CC2.NNc1ccc([N+](=O)[O-])cc1Cl>>CC(=O)Nc1nc2c(s1)-c1c(c(C3CC3)nn1-c1ccc([N+](=O)[O-])cc1Cl)CC2,,CC(=O)O,,Cl,,val
US20050074451A1,CC(C)(C)OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1.CN1CCNCC1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CN1CCN(C(=O)ON[C@@H](Cc2ccccc2)C(=O)OC(C)(C)C)CC1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20030220341A1,Cc1ccc(S(=O)(=O)OCCNC(=O)OC(C)(C)C)cc1.c1c[nH]cn1>>CC(C)(C)OC(=O)NCCn1ccnc1,,CN(C)C=O,,[H-].[Na+],,val
US20070155805A1,CCCOC(CCSc1ccc(OCC(=O)OCC)c(C)c1)c1sc2cc(C(F)(F)F)ccc2c1C>>CCCOC(CCSc1ccc(OCC(=O)O)c(C)c1)c1sc2cc(C(F)(F)F)ccc2c1C,,C1CCOC1,CO,[Na+].[OH-],,val
US08455111B2,Nc1c(N)c2ccccc2c2ccccc12.O=CC(=O)c1ccccc1>>c1ccc(-c2cnc3c4ccccc4c4ccccc4c3n2)cc1,,CCO,,,,val
US20040157886A1,O=C(CCl)Nc1ccc2[nH]c(=O)oc2c1.c1ccc(CC2CCNCC2)cc1>>O=C(CN1CCC(Cc2ccccc2)CC1)Nc1ccc2[nH]c(=O)oc2c1,,O,,,,val
US05981572,CC(=O)NCCCc1ccc(Cl)c2occc12>>CC(=O)NCCCc1ccc(Cl)c2c1CCO2,[Rh],CCO,,,,val
US20090062366A1,C[C@H](c1cccc2ccccc12)N(CC1CNCC1c1ccccc1)C(=O)OC(C)(C)C.O=C=Nc1ccccc1>>C[C@H](c1cccc2ccccc12)N(CC1CN(C(=O)Nc2ccccc2)CC1c1ccccc1)C(=O)OC(C)(C)C,,CCOC(C)=O,,ClCCl,,val
US20090170921A1,BrBr.COCCn1c(-c2ccc(C(C)C)cc2)nc2cc(Cc3ccccc3S(C)=O)cc(OC)c21>>COCCn1c(-c2ccc(C(C)C)cc2)nc2c(Br)c(Cc3ccccc3S(C)=O)cc(OC)c21,,CC(=O)O,,CCOC(C)=O,,val
US20040235862A1,CC1(C)OB(c2ccc(N)cc2)OC1(C)C.C[C@H](Nc1cncc(Cl)n1)c1ccccc1>>C[C@H](Nc1cncc(-c2ccc(N)cc2)n1)c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20080051418A1,CC(C)Oc1nn(CCOCc2ccccc2)cc1CCO.Oc1ccc(Cl)cc1Cl>>CC(C)Oc1nn(CCOCc2ccccc2)cc1CCOc1ccc(Cl)cc1Cl,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US05049551,CCCC(CCC)C(=O)NCC(=O)OC[C@H]1O[C@@H](n2cc(F)c(=O)[nH]c2=O)[C@H](OC2CCCCO2)[C@@H]1OC(=O)CNC(=O)C(CCC)CCC>>CCCC(CCC)C(=O)NCC(=O)OC[C@H]1O[C@@H](n2cc(F)c(=O)[nH]c2=O)[C@H](O)[C@@H]1OC(=O)CNC(=O)C(CCC)CCC,,CCO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20050032786A1,COC(=O)c1ccccc1S.C[Si](C)(C)CCOC(=O)CCCCCCc1cccc(C#N)n1>>C[Si](C)(C)CCOC(=O)CCCCCCc1cccc(-c2nc(=O)c3ccccc3s2)n1,,Cc1ccccc1,,CCN(CC)CC,,val
US20090197862A1,CC1(C)OB(c2cnc(N)c(-c3nc4ccccc4s3)c2)OC1(C)C.COC(=O)Cn1cc(I)cn1>>Nc1ncc(-c2cnn(CC(=O)O)c2)cc1-c1nc2ccccc2s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,[F-].[K+],,val
US05672609,COc1ccc(C(CCC(=O)c2ccc(F)cc2)C(=O)c2ccc(OCc3ccccc3)cc2)cc1.NO>>COc1ccc(-c2ccc(-c3ccc(F)cc3)nc2-c2ccc(OCc3ccccc3)cc2)cc1,,CO,,Cl,,val
US20100029609A1,CC(C)(C)OC[C@H](N)C(=O)OC(C)(C)C.COC(=O)c1ccc(Br)cc1O>>CC(C)(C)OC[C@H](NC(=O)c1ccc(Br)cc1O)C(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04520193,CON=C(C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(C=C(C)Sc3nnc(C)s3)CSC12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(C=C(C)Sc3nnc(C)s3)CSC12)c1csc(N)n1,,O=CO,,,,val
US20100160325A1,CN(C)c1cc(Nc2nc(Cl)ncc2F)n[nH]1.C[C@H](N)c1ncc(F)cn1>>C[C@H](Nc1ncc(F)c(Nc2cc(N(C)C)[nH]n2)n1)c1ncc(F)cn1,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20090048259A1,C[C@H]1CN(c2nnc(Cl)c3ccccc23)CCN1.O=C(Cl)c1ccccc1>>C[C@H]1CN(c2nnc(Cl)c3ccccc23)CCN1C(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US06479495B1,CC(C)[Si](Cl)(C(C)C)C(C)C.CCCCN(C(C)C)C(C)C.OC1(O)C=CC=C(CN2CCCC2)C1>>C#CCOC1(O[Si](C(C)C)(C(C)C)C(C)C)C=CC=C(CN2CCCC2)C1,,CN(C)C=O,,,,val
US20130217680A1,N#Cc1cccc2c1OCCC2CO>>N#Cc1cccc2c1OCCC2C=O,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20160095858A1,CC(C)(C)OC(=O)C1(C)NCc2ccccc21.Cc1cc(C)c(CCl)c(C)c1>>Cc1cc(C)c(CN2Cc3ccccc3C2(C)C(=O)OC(C)(C)C)c(C)c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020004513A1,COc1ccc(CC(=O)N(Cc2ccc(C)cc2)C2CCNCC2)cc1.Cc1nc(CCl)cs1>>COc1ccc(CC(=O)N(Cc2ccc(C)cc2)C2CCN(Cc3csc(C)n3)CC2)cc1,,CC#N,,Cl,[I-].[K+],val
US20070099909A1,NCCc1c[nH]c2ccc(Cl)cc12>>NCCc1c[nH]c2ccc(Cl)cc12,,ClCCl,,Cl,[Na+].[OH-],val
US04221584,BrCc1ccon1.Cc1cccc(C)c1NC(=O)CCl>>Cc1cccc(C)c1N(Cc1ccon1)C(=O)CCl,,CN(C)C=O,,[H-].[Na+],,val
US20130317021A1,CC(C)c1cc(N)[nH]n1.CCOC=C(C(=O)OCC)C(=O)OCC>>CCOC(=O)c1c[nH]c2cc(C(C)C)nn2c1=O,,CC(=O)O,,,,val
US20140135319A1,Cc1cc(-c2cnc3c(NCCC(F)(F)F)nc(C#N)cn23)ccc1C(=O)NC1CC1>>Cc1cc(-c2cnc3c(NCCC(F)(F)F)nc(CN)cn23)ccc1C(=O)NC1CC1,[Ni],N,,,,val
US20160185778A1,CCOC(=O)c1nn(Cc2ccc(OC)cc2)c2c1CN(C(=O)OC(C)(C)C)CC2>>COc1ccc(Cn2nc(CO)c3c2CCN(C(=O)OC(C)(C)C)C3)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120149676A1,CCOC(=O)c1cc([N+](=O)[O-])c(NC)cc1N1CCC(C(F)(F)F)CC1>>CCOC(=O)c1cc(N)c(NC)cc1N1CCC(C(F)(F)F)CC1,[Ni],C1CCOC1,,,,val
US04952573,COc1noc(CBr)c1-c1ccccc1[N+](=O)[O-].Cl>>COc1noc(CCl)c1-c1ccccc1N,,CO,Cl,Cl[Sn]Cl,,val
US20080119422A1,CC(=O)OC[C@H]1O[C@@H](n2ccc3c(Cl)cccc32)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.O=C(Cl)c1ccc2c(c1)CCO2>>CC(=O)OC[C@H]1O[C@@H](n2cc(C(=O)c3ccc4c(c3)CCO4)c3c(Cl)cccc32)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04772600,CCN1CCCC(N)C1.O=C(O)Cn1c(-c2ccc(Br)cc2)nc2cccnc21>>CCN1CCCC(NC(=O)Cn2c(-c3ccc(Br)cc3)nc3cccnc32)C1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20150329523A1,COc1cc(OCCOCCOCCO)cc([N+](=O)[O-])c1>>COc1cc(N)cc(OCCOCCOCCO)c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20080207654A1,CCCCc1nc(C)n(-c2ccccc2)c(=O)c1Cc1c(F)cc(-c2ccccc2C#N)cc1F.O=C([O-])O.[NH3+]O>>CCCCc1nc(C)n(-c2ccccc2)c(=O)c1Cc1c(F)cc(-c2ccccc2-c2noc(=O)[nH]2)cc1F,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20020137955A1,CC(=Cc1ccccc1)C(=O)O.O=S(Cl)Cl>>CC(=Cc1ccccc1)C(=O)Cl,,CN(C)C=O,,,,val
US20080242655A1,CCOC(=O)c1c(O)c2cnccc2n1C.O=S(=O)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>CCOC(=O)c1c(OS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c2cnccc2n1C,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060004084A1,ClCCCN1CCOCC1.O=C1OCc2cc(O)ccc21>>O=C1OCc2cc(OCCCN3CCOCC3)ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140005168A1,CC(C)(C)OC(=O)N1CCCN(c2cncc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)CC1>>FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cncc(N3CCCNCC3)n2)cn1,,C1COCCO1,,Cl,,val
US20150210682A1,CC(C)CBr.CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2CC>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCC(C)C)cc1CC2CC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040092525A1,COC(=O)c1cc2ccc(Cl)cc2[nH]1.N#CCCl>>COC(=O)c1cc2ccc(Cl)cc2n1CC#N,,CN(C)C=O,,[H-].[Na+],,val
US20060276508A1,CCOc1cc(C=O)cc(OCC)c1-c1ccc(F)cc1.CCOc1cc(CN2CCC(NC(=O)c3cc(OC)cc(OCC(O)CO)c3)CC2)cc(OCC)c1Cl>>CCOc1cc(CN2CCC(NC(=O)c3cc(OC)cc(OCC(O)CO)c3)CC2)cc(OCC)c1-c1ccc(F)cc1,,CC(=O)O,CCO,CCN(C(C)C)C(C)C,[BH3-]C#N.[Na+],val
US20150175619A1,FC(F)(Br)Br.O=[N+]([O-])c1ncccc1O>>O=[N+]([O-])c1ncccc1OC(F)(F)Br,,CN1CCCC1=O,,[H-].[Na+],,val
US20050256154A1,CCOC(=O)c1cnc(Cl)c2c(CBr)csc12.COc1ccc(O)c(Cl)c1>>CCOC(=O)c1cnc(Cl)c2c(COc3ccc(OC)cc3Cl)csc12,,C1CCOC1,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20080300242A1,CCc1cc([N+](=O)[O-])c(OC)cc1N1CCC(N2CCN(S(C)(=O)=O)CC2)CC1>>CCc1cc(N)c(OC)cc1N1CCC(N2CCN(S(C)(=O)=O)CC2)CC1,[Pt],CCOC(C)=O,,,,val
US20120220589A1,COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCCc4cc(N(C)C)ccc43)nc2c1>>CN(C)c1ccc2c(c1)CCCN2c1nc2cc(C(=O)O)ccc2nc1-c1ccc(F)cc1,,CO,O,CC(=O)O,[Na+].[OH-],val
US20100130446A1,C=C[Mg]Br.CON(C)C(=O)C(CC1CCOC1)c1ccc(S(C)(=O)=O)cc1>>C=CC(=O)C(CC1CCOC1)c1ccc(S(C)(=O)=O)cc1,,C1CCOC1,,Cl,,val
US20090281082A1,CC1(C)CNC(=O)C2=C(C1)N(S(=O)(=O)c1ccccc1)C(c1ccnc3[nH]ccc13)S2>>CC1(C)CNC(=O)c2sc(-c3ccnc4[nH]ccc34)nc2C1,,CCO,,[Na+].[OH-],,val
US20150119392A1,O=C(O)Cc1ccc(F)cc1Br.O=[N+]([O-])O>>O=C(O)Cc1cc([N+](=O)[O-])c(F)cc1Br,,O=S(=O)(O)O,,,,val
US06166064,CC(=O)c1c2c(cc3c1CCC3)CCC2.CCO>>CC(=[O+][O-])c1c2c(cc3c1CCC3)CCC2,,c1ccncc1,,,,val
US05244908,C1COCCN1.C=O.CS(=O)(=O)NCCSc1cccc2nccn12>>CS(=O)(=O)NCCSc1cccc2ncc(CN3CCOCC3)n12,,CC(=O)O,,,,val
US20160129002A1,CNC.COc1cc(Nc2nc(C=O)cc(COCC(F)(F)F)n2)ccc1-n1cnc(C)c1>>COc1cc(Nc2nc(COCC(F)(F)F)cc(CN(C)C)n2)ccc1-n1cnc(C)c1,,ClCCCl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05143831,C=CCCC(=O)O.CCO>>C=CCCC(=O)OCC,,c1ccccc1,,O=S(=O)(O)O,,val
US20080114005A1,CCOC(=O)C(C)(C)Sc1ccc(OCCCn2c(CC)nc3ccccc3c2=O)cc1>>CCc1nc2ccccc2c(=O)n1CCCOc1ccc(SC(C)(C)C(=O)O)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20070088041A1,O=C1CCC(=O)N1Br.O=c1[nH]nc(-c2cn[nH]c2)cc1-c1cc2ccccc2[nH]1>>O=c1[nH]nc(-c2cn[nH]c2)cc1-c1[nH]c2ccccc2c1Br,,COCCOC,,,,val
US20100113502A1,CC1CCN(C(=O)c2ccc3c(c2)c2c(n3S(=O)(=O)n3ccnc3)CCN(C(=O)OC(C)(C)C)C2)CC1.COS(=O)(=O)C(F)(F)F>>CC1CCN(C(=O)c2ccc3c(c2)c2c(n3S(=O)(=O)n3cc[n+](C)c3)CCN(C(=O)OC(C)(C)C)C2)CC1.O=S(=O)([O-])C(F)(F)F,,CC#N,,,,val
US20150073011A1,C=CCON([C@H]1CN(C(=O)OC(C)(C)C)[C@H](COC)C=C1C(=O)N(C)C)S(=O)(=O)c1ccccc1[N+](=O)[O-]>>C=CCON([C@H]1CN[C@H](COC)C=C1C(=O)N(C)C)S(=O)(=O)c1ccccc1[N+](=O)[O-],,ClCCl,,O=C(O)C(F)(F)F,,val
US20090069340A1,COc1ccc(Cl)cc1N1CCNCC1.Cn1c(CBr)c(Cl)c(=O)n1C1CCCC1>>COc1ccc(Cl)cc1N1CCN(Cc2c(Cl)c(=O)n(C3CCCC3)n2C)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20030144272A1,O.O=C(N1CCNC(CN2CCCC2)C1)C(F)(F)F.On1nnc2ccccc21>>O=C(N1CCNC(CN2CCCC2)C1)C(F)(F)F.[NH4+].[OH-],,ClCCl,O,CCN(C(C)C)C(C)C,CCN=C=NCCCN(C)C,val
US20060211719A1,CC(C)c1ccc(NC(=O)OCc2ccccc2)c(=O)n1CC(=O)OC(C)(C)C>>CC(C)c1ccc(N)c(=O)n1CC(=O)OC(C)(C)C,[Pd],CO,,,,val
US20110172427A1,ClCCCBr.N#CCc1ccccc1C(F)(F)F>>N#CC(CCCCl)c1ccccc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US04980360,CC(Br)CCCN1C(=O)c2ccccc2C1=O.COc1cc(N)c2nccc(C)c2c1OCCCCCCCCCc1ccccc1>>COc1cc(NC(C)CCCN2C(=O)c3ccccc3C2=O)c2nccc(C)c2c1OCCCCCCCCCc1ccccc1,CCN(CC)CC,CCN(CC)CC,,,,val
US20030065005A1,BrCc1ccccc1.OCCn1cnc2cnc3ccccc3c21>>c1ccc(COCCn2cnc3cnc4ccccc4c32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20140135332A1,CN(C)C(=O)C(Br)c1nc(-c2ccc(Cl)cc2)cs1.NC(=O)c1c(F)ccc(O)c1F>>CN(C)C(=O)C(Oc1ccc(F)c(C(N)=O)c1F)c1nc(-c2ccc(Cl)cc2)cs1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04347358,C[Si](C)(C)N[Si](C)(C)C.O=C(Cc1ccccc1)NC1C(=O)N2C(C(=O)O)=C(CBr)CS(=O)[C@H]12>>C[Si](C)(C)OC(=O)C1=C(CBr)CS(=O)[C@@H]2C(NC(=O)Cc3ccccc3)C(=O)N12,,ClCCl,,,,val
US05977106,Cl.FC(F)(F)c1cccc(N2CCNCC2)c1.O=c1cnn(CCCCCl)c(=O)[nH]1>>Cl.O=c1cnn(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)c(=O)[nH]1,,CCOCC,,Cc1ccccc1C,,val
US20160016948A1,CC(C)I.O=C1CC(c2c[nH]c3cc(Br)ncc23)CN1>>CC(C)n1cc(C2CNC(=O)C2)c2cnc(Br)cc21,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20020052322A1,COC(=O)[C@@H](N)Cc1cscn1.C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O>>COC(=O)[C@H](Cc1cscn1)NC(=O)[C@H](C)NC(=O)Cc1cc(F)cc(F)c1,,CO,ClCCl,Cl,,val
US20100240702A1,COC(=O)CCn1c(=O)n(Cc2cc(Cl)cc3c2ccn3C(=O)OC(C)(C)C)c2ccccc21>>COC(=O)CCn1c(=O)n(Cc2cc(Cl)cc3[nH]ccc23)c2ccccc21,,CO,ClCCl,O=C(O)C(F)(F)F,,val
US20120214769A1,CC(C)Cc1ccc(B(O)O)cc1.COC(=O)c1ccc(C=C(Br)C(=O)OCc2ccccc2)cc1>>COC(=O)c1ccc(C=C(C(=O)OCc2ccccc2)c2ccc(CC(C)C)cc2)cc1,Cc1ccccc1[P](c1ccccc1C)(c1ccccc1C)[Pd](Cl)(Cl)[P](c1ccccc1C)(c1ccccc1C)c1ccccc1C,CCO,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20060030613A1,CC(C)(C)c1ccc(CNCCc2cccc(OC(F)F)c2)cc1.O=C(O)c1cc(Cl)cc2cc[nH]c12>>CC(C)(C)c1ccc(CN(CCc2cccc(OC(F)F)c2)C(=O)c2cc(Cl)cc3cc[nH]c23)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20130116285A1,COC(=O)c1cc(Br)c(Oc2ccc(Cl)cc2OC)cc1F.COc1ncccc1B(O)O>>COC(=O)c1cc(-c2cccnc2OC)c(Oc2ccc(Cl)cc2OC)cc1F,,O,,,,val
US20070179164A1,COc1cccc(C=O)c1O.Cc1nc2ccncc2c(=O)n1-c1ccccc1>>COc1cccc(/C=C/c2nc3ccncc3c(=O)n2-c2ccccc2)c1O,,CC(=O)O,,,,val
US20080015199A1,BrCCOC1CCCCO1.COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(O)c(OC)c(OC)c1>>COC(=O)N=C(SC)C(Nc1ccc(-c2noc(C)n2)cc1)c1cc(OC)c(OC)c(OCCOC2CCCCO2)c1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20070185155A1,BrCCCOc1cccc(-c2ccccc2)c1.OC(c1ccccc1)(c1ccccc1)C12CCN(CC1)CC2>>OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3cccc(-c4ccccc4)c3)(CC1)CC2.[Br-],,CC#N,,,,val
US06281227B1,COc1ccc2ccc(S(=O)(=O)Cl)cc2c1.N[C@H]1CCN(Cc2cccc3nc(Cl)ccc23)C1=O>>COc1ccc2ccc(S(=O)(=O)N[C@H]3CCN(Cc4cccc5nc(Cl)ccc45)C3=O)cc2c1,,ClCCl,,Cl,,val
US20070173486A1,CO[C@H](C(=O)O)c1ccccc1.Clc1ccc(C(OC2CNC2)c2ccc(Cl)cc2Cl)cc1>>CO[C@H](C(=O)N1CC(OC(c2ccc(Cl)cc2)c2ccc(Cl)cc2Cl)C1)c1ccccc1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20100136136A1,CC(C)(C)OC(=O)N1CCC(OS(C)(=O)=O)CC1.Cc1cc(O)ccc1[N+](=O)[O-]>>Cc1cc(OC2CCN(C(=O)OC(C)(C)C)CC2)ccc1[N+](=O)[O-],,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080319016A1,CC(=O)OC(C)=O.NC(=O)c1ccc(OCCCN2CCC(CCCOc3ccc(C(N)=NO)cc3)CC2)cc1>>CC(=O)ON=C(N)c1ccc(OCCCC2CCN(CCCOc3ccc(C(N)=O)cc3)CC2)cc1,,CC(=O)O,,,,val
US20060009487A1,COC(=O)c1c(-c2ccccc2)c(-c2ccccc2)n(C(C)C)c1C(=O)NCCCCN(C(=N)NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>CC(C)n1c(C(=O)NCCCCN(C(=N)N)C(=O)OC(C)(C)C)c(C(=O)O)c(-c2ccccc2)c1-c1ccccc1,,CO,,[Na+].[OH-],,val
US20080207654A1,CCCc1nc(CC)c(-c2ccc(OC(C)C)c(F)c2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCc1nc(CC)c(-c2ccc(OC(C)C)c(F)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,O,,CS(C)=O,[Cl-].[Na+],val
US20100305145A1,C[C@H](C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)NS(C)(=O)=O>>C[C@H](C[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)NS(C)(=O)=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160257652A1,CCOC(=O)[C@H]1[C@@H]2Cc3cc(OCc4cc(-c5ccc(N6CC7(CN(C(=O)OC(C)(C)C)C7)C6)cc5F)c(C(F)(F)F)cc4F)ncc3[C@H]12>>CCOC(=O)[C@H]1[C@@H]2Cc3cc(OCc4cc(-c5ccc(N6CC7(CNC7)C6)cc5F)c(C(F)(F)F)cc4F)ncc3[C@H]12,,ClCCl,,O,O=C(O)C(F)(F)F,val
US20100022590A1,COC(=O)c1cnoc1-c1ccccc1C>>Cc1ccccc1-c1oncc1C(=O)O,,CC(=O)O,O,Cl,,val
US20130237537A1,CC(C)(C)c1ccc(N)cc1.Nc1ncc2c(n1)CCN(c1cccc(C(=O)O)c1)C2>>CC(C)(C)c1ccc(NC(=O)c2cccc(N3CCc4nc(N)ncc4C3)c2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150110809A1,CCc1ccc[nH]1.O=S(=O)(Cl)c1ccc(Cl)cc1>>CCc1cccn1S(=O)(=O)c1ccc(Cl)cc1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US06140351,Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1.O=C(Cl)c1scc(CCl)c1Cl>>O=C(Nc1ccc(Cl)cc1)c1cc(Cl)ccc1NC(=O)c1scc(CCl)c1Cl,,ClCCl,,c1ccncc1,,val
US20150307451A1,COC(=O)c1cc(Br)c(C)c(C)c1N.O=S(=O)(O)O>>COC(=O)c1cc(Br)c(C)c(C)c1O,,O=S(=O)(O)O,,O=N[O-].[Na+],,val
US05753679,O=C(Cl)c1ccc(Cl)cc1.OC1CCN(Cc2ccc(Br)cc2)CC1>>O=C(OC1CCN(Cc2ccc(Br)cc2)CC1)c1ccc(Cl)cc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20080027041A1,CNN.COc1ccc(C2=CC(=O)OC2O)cc1>>COc1ccc(-c2cnn(C)c(=O)c2)cc1,,CCO,,,,val
US20140088053A1,C[C@]12CC[C@@H]3c4ccc(C(N)=O)cc4CC[C@H]3[C@@H]1C/C(=C\c1cccc(C(N)=O)c1)[C@@H]2O>>C[C@]12CC[C@@H]3c4ccc(C(N)=O)cc4CC[C@H]3[C@@H]1C[C@H](Cc1cccc(C(N)=O)c1)[C@@H]2O,[Pd],CCO,,,,val
US20150126498A1,COc1ccc(NS(=O)(=O)c2cnccc2NCc2c(F)cccc2Cl)cc1OC.O=C(n1ccnc1)n1ccnc1>>COc1ccc(N2C(=O)N(Cc3c(F)cccc3Cl)c3ccncc3S2(=O)=O)cc1OC,,ClCCCl,,,,val
US20160068532A1,Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc(N)c(CCN[C@H](C)c4ccc(F)cc4)cc23)ccn1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COC(=O)N(CCc1cc2c(-c3ccnc(C)c3)nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c2cc1N)[C@H](C)c1ccc(F)cc1,,C1COCCO1,,,,val
US20050137171A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COP(=O)(Oc1ccc2[nH]nc(I)c2c1)c1ccccc1>>COP(=O)(Oc1ccc2c(c1)c(I)nn2C(=O)OC(C)(C)C)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20140005146A1,CC(C)C[C@H](N)CO.NC(=O)c1cnn2cc(Br)cc2c1Cl>>CC(C)C[C@@H](CO)Nc1c(C(N)=O)cnn2cc(Br)cc12,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20060122064A1,CCOC(=O)CP(=O)(OCC)OCC.COc1cc(C=O)cc(F)c1OCc1ccccc1>>CCOC(=O)C=Cc1cc(F)c(OCc2ccccc2)c(OC)c1,,O,,C1CCOC1,[H-].[Na+],val
US20100063013A1,CC(C)(F)C[C@H](N)CO.O=C(c1ccc(Br)cc1)C(F)(F)F>>CC(C)(F)C[C@H]1CO[C@](c2ccc(Br)cc2)(C(F)(F)F)N1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US06350749B1,CC(O)=C1C(=O)CC(c2sccc2Cl)CC1=O.NN>>Cc1n[nH]c2c1C(=O)CC(c1sccc1Cl)C2,,CCO,,O,,val
US20060189604A1,CC(C)[Si](Oc1cccc(N)c1N)(C(C)C)C(C)C.CCOC(=O)C=O>>CC(C)[Si](Oc1cccc2[nH]c(=O)cnc12)(C(C)C)C(C)C,,CCO,,Cc1ccccc1,,val
US20100298287A1,CC(=O)Cl.CCN(CC)c1cccc2nc(Nc3ccc(Cl)cc3Cl)n(CC(O)CO)c12>>CCN(CC)c1cccc2nc(Nc3ccc(Cl)cc3Cl)n(CC(O)COC(C)=O)c12,,c1ccncc1,,,,val
US04942170,CN(C)CCCNC(=S)NN.CS(=O)(=O)O.O=Cc1ccc([N+](=O)[O-])o1>>CN(C)CCCNC(=S)NN=Cc1ccc([N+](=O)[O-])o1.CS(=O)(=O)O,,CCO,,CC(C)O,,val
US20140142083A1,CI.COC(=O)c1cc(Cl)cc(NC2CCOCC2)c1C>>COC(=O)c1cc(Cl)cc(N(C)C2CCOCC2)c1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060235069A1,N#Cc1cc(Br)ccc1NC(=O)c1ccccn1>>NCc1cc(Br)ccc1NC(=O)c1ccccn1,[Ni],CO,,N,[H][H],val
US20030114666A1,NC(=O)NC1CC1.O=C(O)c1cc(F)c(F)c(C(F)F)c1F>>O=C(NC(=O)c1cc(F)c(F)c(C(F)F)c1F)NC1CC1,CN(C)C=O,CCOC(C)=O,ClCCl,O=C(Cl)C(=O)Cl,,val
US05021478,CCCCCCCCON1C(C)(C)CC(O)CC1(C)C.COC(=O)COc1ccc(C(=O)c2ccccc2)c(O)c1>>CCCCCCCCON1C(C)(C)CC(OC(=O)COc2ccc(C(=O)c3ccccc3)c(O)c2)CC1(C)C,,Cc1ccccc1C,,,,val
US20080293749A1,N.N#CCOC(=O)c1ccc(F)cc1N>>NC(=O)c1ccc(F)cc1N,,C1COCCO1,,,,val
US20160068559A1,CC(CC=O)NC(=O)Nc1ccc(C(C)(C)C)cc1.CNC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21>>CC(CCN(C)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21)NC(=O)Nc1ccc(C(C)(C)C)cc1,,ClCCCl,,O=C([O-])O.[Na+],,val
US05958918,BrCc1ccccc1.O=S(=O)(O)c1ccc2ccc(O)cc2c1.[Na]>>O=S(=O)(O)c1ccc2ccc(OCc3ccccc3)cc2c1.[Na],,CN(C)C=O,,[H-].[Na+],,val
US20160237067A1,CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](C(=O)N[C@@H](Cc2ccc(-c3cccc(C(=O)N4CCOCC4)c3)cc2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)CC1.Cl>>Cl.NC[C@@H]1CC[C@@H](C(=O)N[C@@H](Cc2ccc(-c3cccc(C(=O)N4CCOCC4)c3)cc2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)CC1,,C1CCOC1,C1COCCO1,,,val
US20030130270A1,COCC(COC)Oc1ccccc1.O=S(=O)(O)Cl>>COCC(COC)Oc1ccc(S(=O)(=O)Cl)cc1,,ClC(Cl)Cl,,,,val
US08431695B2,CC(C)(C)OC(=O)N1CCCC(O)(c2ccc3c(N)ncnn23)CC1>>CC(C)(C)OC(=O)N1CC=C(c2ccc3c(N)ncnn23)CCC1,,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20110190342A1,Cc1cccc(Oc2ccc(C[C@H](N)C(=O)O)cc2)n1.O=C(O)c1cc2cc(Cl)ccc2nc1Cl>>Cc1cccc(Oc2ccc(C[C@H](Nc3nc4ccc(Cl)cc4cc3C(=O)O)C(=O)O)cc2)n1,,CS(C)=O,,,,val
US20160272632A1,C1C[C@@H]2CNC[C@H]1O2.Cc1cc(Br)ccc1C(=O)Cl>>Cc1cc(Br)ccc1C(=O)N1CC2CCC(C1)O2,,ClCCl,,CCN(CC)CC,,val
US20070225318A1,Nc1ccnc2ccc(Br)cc12.O=c1c2ccnn2c(=O)c2ccnn12>>O=C(Nc1ccnc2ccc(Br)cc12)c1cc[nH]n1,CN(C)c1ccncc1,CN(C)C=O,,,,val
US04343811,CCCn1c(C)c(-c2ccncc2)c2cc(OC(C)(C)C(=O)O)ccc21.CN>>CCCn1c(C)c(-c2ccncc2)c2cc(OC(C)(C)C(=O)NC)ccc21,,C1COCCO1,,Cl,,val
US20090093456A1,COc1cc(Br)ccc1O.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1cc(Br)ccc1OS(=O)(=O)c1ccc(C)cc1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20150239884A1,COc1nc(C#C[Si](C)(C)C)ccc1[N+](=O)[O-]>>C#Cc1ccc([N+](=O)[O-])c(OC)n1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20110015175A1,Cc1ncn(-c2ccc(N)cc2C#N)n1.O=c1ccccn1C(=S)n1ccccc1=O>>Cc1ncn(-c2ccc(N=C=S)cc2C#N)n1,,ClCCl,,,,val
US20110166121A1,CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(OCCC(OC)OC)nc2s1>>CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(O)nc2s1,,CCOC(C)=O,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20070032481A1,CNC.Cc1ccc(-c2cc(C=O)nc(Cc3ccccc3)n2)cc1>>Cc1ccc(-c2cc(CN(C)C)nc(Cc3ccccc3)n2)cc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090181948A1,CC(C)(C)OC(=O)N1CCC(COS(C)(=O)=O)CC1.N#CC(C#N)=C1NCCN1CCCO>>CC(C)(C)OC(=O)N1CCC(CN2CCN(CCCO)C2=C(C#N)C#N)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090030020A1,C#Cc1ccccc1Cl.COC(=O)c1nc(SC)ncc1Br>>COC(=O)c1nc(SC)ncc1C#Cc1ccccc1Cl,[Cu]I,CN(C)C=O,ClCCl,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US07094789B2,CC(C)(C)OC(=O)N[C@H]1CC[C@@H](Oc2cccc3c(Cl)nccc23)CC1.N>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](Oc2cccc3c(N)nccc23)CC1,,C1COCCO1,,,,val
US04489093,CCOC(=O)/C(F)=C/[C@@H]1[C@@H](C(=O)O)C1(C)C.N#C[C@@H](O)c1cccc(Oc2ccccc2)c1>>CCOC(=O)/C(F)=C/[C@@H]1[C@@H](C(=O)O[C@H](C#N)c2cccc(Oc3ccccc3)c2)C1(C)C,,ClC(Cl)Cl,,,,val
US20080103123A1,O=S(Cl)Cl.OCc1ccc(Br)cn1>>ClCc1ccc(Br)cn1,,ClCCl,,,,val
US20040106655A1,CC(C)(C)OC(=O)N1C[C@H](Nc2nc3ccccc3o2)C[C@H]1C(=O)O.Cl.N#C[C@@H]1CCCN1>>Cl.N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](Nc2nc3ccccc3o2)CN1,,CN(C)C=O,,,,val
US20160229872A1,CCOC(=O)CS.Cc1ccc(S(=O)(=O)ON=C(C#N)c2cccc(C)c2)cc1>>CCOC(=O)c1snc(-c2cccc(C)c2)c1N,,CCN(CC)CC,,CO,,val
US06982324B1,C=C(C)C(=O)OCC(C)O.NCCSSCCN>>C=C(C)C(=O)OCC(C)O.NCCSSCCN,,CO,,CCN(CC)CC,Cl,val
US20080021226A1,CC(=O)OC(C)=O.CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](O)CC[C@@H]1C>>CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1C,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US06080870,CCCCc1cc(C(=O)OCCCl)ccc1-c1ccccc1>>CCCCc1cc(-c2ccccc2)ccc1CO,,C1CCOC1,CCCCCC,Cl,[BH4-].[Li+],val
US20130023519A1,COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1N.O=S(=O)(Cl)c1ccc(Cl)s1>>COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccc(Cl)s1,,ClCCl,,O,c1ccncc1,val
US20070027321A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.CCOc1cc(Br)cnc1Nc1cccc(C)n1>>CCOc1cc(-c2ccccn2)cnc1Nc1cccc(C)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US05057614,CC1CO1.CN(C)C=O.C[Si](C)(C)Cl.O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1c[nH]c2ccccc12>>CC(O)Cn1cc(C2=C(c3cn(CC(C)O)c4ccccc34)C(=O)NC2=O)c2ccccc21,,CN(C)C=O,O,[H-].[Na+],,val
US20070281918A1,CC1CN(C(=O)C(F)(F)F)CCc2c(O)cc(=O)[nH]c21.O=P(Br)(Br)Br>>CC1CN(C(=O)C(F)(F)F)CCc2c(Br)cc(=O)[nH]c21,,CN(C)C=O,,,,val
US20130178457A1,CCN(C(C)C)C(C)C.COc1ncc(S(=O)(=O)Cl)c2c(C)cccc12>>COc1ncc(S(N)(=O)=O)c2c(C)cccc12,,ClCCl,,,,val
US20150087639A1,COC(=O)/C=C(/C)NC(=O)CCc1cccc(F)c1.Nc1ccc(N2CCOCC2)c(F)c1>>Cc1cc(=O)n(-c2ccc(N3CCOCC3)c(F)c2)c(CCc2cccc(F)c2)n1,,ClCCl,,C[Al](C)C,,val
US20150175540A1,CON(C)C(=O)[C@@H]1CC[C@@H](CN2Cc3ccc(O)cc3C2=O)CC1>>O=C[C@@H]1CC[C@@H](CN2Cc3ccc(O)cc3C2=O)CC1,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20020013316A1,COC(=O)c1nccnc1O.C[C@H](N)C(=O)N[C@@H](C)C(=O)O>>C[C@H](NC(=O)[C@H](C)NC(=O)c1ncc[nH]c1=O)C(=O)O,,CS(C)=O,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20020132806A1,CCOC(=O)c1cc2ccccc2nc1N.O=C(Cl)c1ccccc1-c1ccc(C(F)(F)F)cc1>>CCOC(=O)c1cnc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2c1,,ClC(Cl)Cl,,c1ccncc1,,val
US20050203091A1,Fc1ccc(Oc2cc3[nH]ncc3cn2)c(F)c1.II>>Fc1ccc(Oc2cc3[nH]nc(I)c3cn2)c(F)c1,,CN(C)C=O,,[K+].[OH-],,val
US20080261946A1,N#CCBr.N#Cc1cc(Cl)ccc1O>>N#CCOc1ccc(Cl)cc1C#N,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05719182,CCCOc1ccc2c(c1)C(c1ccc(OC)cc1OCC(=O)OC(C)(C)C)C(CC#N)C2c1ccc2c(c1)OCO2>>CCCOc1ccc2c(c1)C(c1ccc(OC)cc1OCC(=O)O)C(CC#N)C2c1ccc2c(c1)OCO2,,ClCCl,,O=C(O)C(F)(F)F,,val
US05025031,COc1cccc(OCCO)c1.NS(=O)(=O)Cl>>COc1cccc(OCCOS(N)(=O)=O)c1,,CCOCC,,,,val
US20130072467A1,C#CCCNC1=NC(=O)SC1.O=CC1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1>>C#CCCNC1=NC(=O)S/C1=C\C1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1,,CC(C)O,,C1CC[NH2+]CC1.CC(=O)[O-],,val
US20110251173A1,CS(=O)(=O)OCc1ccc(Br)c(Cl)c1.Oc1ncccn1>>O=c1ncccn1Cc1ccc(Br)c(Cl)c1,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20130029954A1,C=C(C)[C@@H]1CC[C@]2(CNCCN(C)C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC(C)(C)C)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CC(C)(C)OC(=O)CC(=O)[O-]>>C=C(C)[C@@H]1CC[C@]2(CN(CCN(C)C)C(=O)CC(=O)OC(C)(C)C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC(C)(C)C)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,CN(C)c1ccncc1,ClCCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120077811A1,C#Cc1cccc(Nc2ncnc3cnc(F)cc23)c1.COc1ccc(CN)cc1>>C#Cc1cccc(Nc2ncnc3cnc(NCc4ccc(OC)cc4)cc23)c1,,CS(C)=O,,,,val
US04199570,Cl.O=C(O)C1(O)CN(C(c2ccccc2)c2ccccc2)C1>>Cl.O=C(O)C1(O)CNC1,[Pd],C1COCCO1,,,,val
US20160095858A1,C[C@@H](COCc1ccccc1)Oc1ccc(-c2ccc(C(=O)NS(=O)(=O)c3cccnc3N)c(N3C[C@@H](C)CC3(C)C)n2)cn1>>C[C@@H](CO)Oc1ccc(-c2ccc(C(=O)NS(=O)(=O)c3cccnc3N)c(N3C[C@@H](C)CC3(C)C)n2)cn1,[Pd],CO,,[H][H],,val
US20030087901A1,Nc1ccc(Cl)cc1Cl.O=C(Cl)Cc1cccc(OCc2ccccc2)c1>>O=C(Cc1cccc(OCc2ccccc2)c1)Nc1ccc(Cl)cc1Cl,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20110190330A1,C=CC(C)(C)C1c2cc(CO[Si](C)(C)C(C)(C)C)ccc2-c2c(F)ccc(OC)c21>>C=CC(C)(C)C1c2cc(CO)ccc2-c2c(F)ccc(OC)c21,,CO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20080113923A1,CC(C)CCCC(C)CCCC(C)CCCC(C)CCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.O>>CC(C)CCCC(C)CCCC(C)CCCC(C)CCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.O,,O,,,,val
US20060183734A1,O=C(Cl)c1ccc(C2CCCCC2)cc1.c1cnc2c(c1)NCc1cccn1C2>>O=C(c1ccc(C2CCCCC2)cc1)N1Cc2cccn2Cc2ncccc21,,ClCCCl,,CCN(CC)CC,,val
US20040122057A1,CCO.CCOC(C(=O)O)c1ccc(OC)cc1F>>CCOC(=O)C(OCC)c1ccc(OC)cc1F,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US05760032,CCc1cc2c(s1)-n1c(Br)nnc1CN=C2c1ccccc1Cl.O=C(Cl)c1cc2ccccc2[nH]1.O=C([O-])O>>CCc1cc(C(=O)c2ccccc2Cl)c(-n2c(Br)nnc2CNC(=O)c2cc3ccccc3[nH]2)s1,,ClC(Cl)Cl,,O=S(=O)(O)O,,val
US04515946,O=C1c2ccccc2COc2ccc(CCO)cc21.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)OCCc1ccc2c(c1)C(=O)c1ccccc1CO2,,Cc1ccccc1,,ClCCl,,val
US20070088041A1,COc1nnc(-c2ccncc2)cc1-c1cc2ccc(CN3CCCCC3)cc2n1C(=O)OC(C)(C)C>>COc1nnc(-c2ccncc2)cc1-c1cc2ccc(CN3CCCCC3)cc2[nH]1,O,ClCCl,,O=C(O)C(F)(F)F,,val
US20060035306A1,O=[N+]([O-])c1ccc(C=Cc2c3ccccc3nc3ccccc23)cc1>>Nc1ccc(C=Cc2c3ccccc3nc3ccccc23)cc1,,CCO,CCOC(C)=O,Cl[Sn]Cl,,val
US20060100229A1,COCCn1nc2c(N)nc3ccccc3c2c1CC(C)(C)O>>CC(C)(O)Cc1c2c(nn1CCO)c(N)nc1ccccc12,,ClCCl,,BrB(Br)Br,,val
US04536507,N#Cc1ccc2c(c1)S(=O)(=O)c1ccc([N+](=O)[O-])cc1C=C2>>N#Cc1ccc2c(c1)S(=O)(=O)c1ccc(N)cc1C=C2,,C1CCOC1,,Cl,[Na+].[OH-],val
US20110052578A1,BrBr.C[Si](C)(C)CCOCn1cc(-c2ccncn2)nc1C1CC1>>C[Si](C)(C)CCOCn1c(C2CC2)nc(-c2ccncn2)c1Br,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US20130225614A1,Cn1cnc([N+](=O)[O-])c1.O=C(c1ccc(F)cc1)c1nc(Cl)c2ccccc2n1>>Cn1cnc(Nc2nc(C(=O)c3ccc(F)cc3)nc3ccccc23)c1,[Pd],CCO,,CN(C)C=O,,val
US20100160369A1,NC(Cc1ccc(-c2noc(-c3cn4cc(C(F)(F)F)cc(Cl)c4n3)n2)c(Cl)c1)=NO.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]c(Cc2ccc(-c3noc(-c4cn5cc(C(F)(F)F)cc(Cl)c5n4)n3)c(Cl)c2)no1,,C1CCOC1,,,,val
US04732998,O=CO.OCCCl.Oc1ccc(Cl)cc1>>O=COCCOc1ccc(Cl)cc1,,O,,[Na+].[OH-],,val
US20140275027A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc(C2=NCCN2)cc1Br>>COc1ccc(C2=NCCN2C(=O)OC(C)(C)C)cc1Br,,ClCCl,,CCN(CC)CC,,val
US20060270706A1,CCOC(=O)CCCn1nnnc1/C=C1\CN(C(C(=O)C2CC2)c2ccccc2F)CCC1S.Cl>>Cl.O=C(O)CCCn1nnnc1/C=C1\CN(C(C(=O)C2CC2)c2ccccc2F)CCC1S,,Cl,,CC#N,,val
US20030181731A1,COC(=O)CC#N.O=[N+]([O-])c1ccc(F)cc1F>>COC(=O)C(C#N)c1cc(F)ccc1[N+](=O)[O-],,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US05843983,COCOc1ccc(F)cc1CCc1ccc(F)c(OC)c1>>COc1cc(CCc2cc(F)ccc2O)ccc1F,,CCOC(C)=O,,Cl,,val
US20160024091A1,CC(C)(C)[Si](C)(C)OCC(O)Cc1ccc(-n2cnnn2)nc1>>CC(C)(C)[Si](C)(C)OCC(=O)Cc1ccc(-n2cnnn2)nc1,,ClCCl,,,,val
US04028356,NNC1=Nc2ccc(Br)cc2C(c2ccccn2)=NC1.O=C(CCl)CBr>>ClCC(CBr)=NNC1=Nc2ccc(Br)cc2C(c2ccccn2)=NC1,,C1CCOC1,,,,val
US20020091067A1,N.O=C(Cl)c1snc(Cl)c1Cl>>NC(=O)c1snc(Cl)c1Cl,,O,,,,val
US20160095858A1,Cc1cc(C)c(Oc2ncc(-c3ccccc3)cc2C(=O)NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c(C)c1>>Cc1cc(C)c(Oc2ncc(-c3ccccc3)cc2C(=O)NS(=O)(=O)c2cccc(N)c2)c(C)c1,[Zn],CC(=O)O,,,,val
US20150152108A1,CC1(C)OC[C@@H](CO)O1.Nc1cncc(Cl)n1>>CC1(C)OC[C@@H](COc2cncc(N)n2)O1,,C1CCOC1,,[H-].[Na+],,val
US04220761,CC(=O)OC(C)=O.Nc1nc(C(=NOCCO)C(=O)O)cs1.O=CO>>O=CNc1nc(C(=NOCCOC=O)C(=O)O)cs1,,O=CO,,CC(C)OC(C)C,,val
US20070208054A1,CCC(C(=O)O)c1ccc(Br)cc1>>CCC(CO)c1ccc(Br)cc1,,C1CCOC1,,CCOC(C)=O,,val
US20040102450A1,BrC(Br)(Br)Br.CSc1ncc(CO)cn1>>CSc1ncc(CBr)cn1,,c1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090054434A1,BrBr.CCn1ccc2cc(OC)c(OC)cc2c1=O>>CCn1cc(Br)c2cc(OC)c(OC)cc2c1=O,,CC(=O)O,,,,val
US05866568,CC(C)(C)[Si](C)(C)Cl.CC(CO)Cc1ccc(Br)cc1>>CC(CO[Si](C)(C)C(C)(C)C)Cc1ccc(Br)cc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20140057301A1,CC(C)(C)[Si](C)(C)Cl.Cc1nc2n(c(=O)c1CCCl)CCCC2O>>Cc1nc2n(c(=O)c1CCCl)CCCC2O[Si](C)(C)C(C)(C)C,,CN(C)C=O,,c1c[nH]cn1,,val
US05149825,C1=CCC=C1.C=O.NCC(N)=O>>NC(=O)CN1CC2C=CC1C2,,ClCCl,O,Cl,,val
US20110178056A1,CC(C)Oc1ccc(C(=O)NCCO)cc1C#N>>CC(C)Oc1ccc(C2=NCCO2)cc1C#N,,ClCCl,,O=S(Cl)Cl,,val
US20040235840A1,CC(C)(S)CCC(=O)O.CSS(C)(=O)=O>>CSSC(C)(C)CCC(=O)O,,CCO,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090209524A1,CCCCN.COC(=O)c1ccc(Cc2c(C)nc(N)nc2Cl)c(OC)c1>>CCCCNc1nc(N)nc(C)c1Cc1ccc(C(=O)OC)cc1OC,,C1COCCO1,,,,val
US06242449B1,CCOC(=O)CCCn1cc(C(=O)c2ccc(N)c(OCCCCl)c2)c2ccccc21.COc1ccccc1N1CCNCC1.Cl>>CCOC(=O)CCCn1cc(C(=O)c2ccc(N)c(OCCCN3CCN(c4ccccc4OC)CC3)c2)c2ccccc21.Cl,,CCOC(C)=O,CN(C)C=O,[I-].[K+],,val
US20080251169A1,Cl.N=C(NN)NN.O=C([O-])C(F)(F)F.[Na+]>>NC(N)=[N+](N)N.O=C([O-])C(F)(F)F.[Cl-].[Na+],,CC(C)=O,,CC#N,,val
US20150203505A1,CCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O>>COc1ccc2[nH]c(C(=O)O)c(CCNC(C)=O)c2c1,,CCO,,C1CCOC1,[Na+].[OH-],val
US20070213331A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.COC(=O)c1cc(Cl)nc(Cl)c1>>C=C(OCC)c1cc(C(=O)OC)cc(Cl)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05204464,Cl.N#Cc1cc(-c2ccncc2)cnc1N1CCOCC1.O>>Cl.N#Cc1cc(-c2ccncc2)cnc1N1CCOCC1.O,,O,,,,val
US05225431,BrCc1ccccc1.O=C1CNC(=O)N1Cc1ccc([N+](=O)[O-])cc1>>O=C1CN(Cc2ccccc2)C(=O)N1Cc1ccc([N+](=O)[O-])cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040102436A1,COCOc1cccc2c1CCC2N(C)c1cnc(-c2ccccc2)c(-c2ccccc2)n1>>CN(c1cnc(-c2ccccc2)c(-c2ccccc2)n1)C1CCc2c(O)cccc21,,CCOC(C)=O,Cl,O,O=C([O-])O.[Na+],val
US20050085465A1,COc1cc2c(Cl)ncnc2cc1OCCN1CCN(C(C)=O)CC1.Oc1cnc2[nH]ccc2c1>>COc1cc2c(Oc3cnc4[nH]ccc4c3)ncnc2cc1OCCN1CCN(C(C)=O)CC1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20040167155A1,CC(N)c1ccccc1-c1ccc(Cl)cc1F.COc1cccc(S(=O)(=O)Cl)c1>>COc1cccc(S(=O)(=O)NC(C)c2ccccc2-c2ccc(Cl)cc2F)c1,,CC#N,,CCN(CC)CC,,val
US20120015969A1,CC(C)(C)OC(=O)N1C[C@@H](C(=O)O)C[C@@H](C2CCCCC2)C1>>CC(C)(C)OC(=O)N1C[C@H](CO)C[C@H](C2CCCCC2)C1,,C1CCOC1,,,,val
US20070043040A1,COc1ccc(C(NCCCOc2ccc(Cl)cc2Cc2ccccc2)c2ccc(OC)cc2)cc1.N#CCBr>>COc1ccc(C(c2ccc(OC)cc2)N(CC#N)CCCOc2ccc(Cl)cc2Cc2ccccc2)cc1,,C1COCCO1,CCOC(C)=O,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20140378459A1,CC(=O)c1ccc(OCc2ccccc2)cc1Cl.CC(C)(C)OC(=O)CN>>CC(NCC(=O)OC(C)(C)C)c1ccc(OCc2ccccc2)cc1Cl,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05495020,Cc1c(N)c(F)c(C)c(F)c1F>>Cc1cc(F)c(C)c(F)c1F,,CN(C)C=O,,CC(C)(C)ON=O,,val
US20100136142A1,C=Cc1cc(C#N)ccc1C=O>>CCc1cc(C#N)ccc1C=O,[Pd],CCO,,,,val
US20090163714A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.FC(F)(F)c1cccc(-c2c[nH]c(C3CCNCC3)n2)c1>>CC(C)(C)OC(=O)N1CCC(c2nc(-c3cccc(C(F)(F)F)c3)c[nH]2)CC1,,C1CCOC1,,CCN(CC)CC,ClCCl,val
US20100305133A1,CCOC(=O)CNC(=O)c1c(O)c(Br)cc2nccnc12.OB(O)c1ccc(Br)cc1F>>CCOC(=O)CNC(=O)c1c(O)c(-c2ccc(Br)cc2F)cc2nccnc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20150038438A1,CCN(Cc1cc2cc3c(cc2n1C)[C@H](O)[C@H](O)Cc1c(OCc2ccccc2)c(C(=O)OC)c(=O)n(Cc2ccc(OC)cc2OC)c1-3)C(=O)OC(C)(C)C>>CCN(Cc1cc2cc3c(cc2n1C)[C@H](O)[C@H](O)Cc1c(O)c(C(=O)OC)c(=O)n(Cc2ccc(OC)cc2OC)c1-3)C(=O)OC(C)(C)C,[Pd],CCOC(C)=O,,,,val
US20100256097A1,CC(C)(C)OC(=O)NCc1cn(Cc2cccc(Nc3sc(-c4c(F)cc(C(C)(C)O)cc4F)cc3C(N)=O)n2)nn1>>CC(C)(O)c1cc(F)c(-c2cc(C(N)=O)c(Nc3cccc(Cn4cc(CN)nn4)n3)s2)c(F)c1,,CCOC(C)=O,,C1COCCO1,Cl,val
US20100137281A1,COC(=O)c1cc(C(C)C)sc1N.NCCc1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)c1cc2c(=O)n(CCc3ccccc3)c(=O)[nH]c2s1,,ClCCl,,CCN(CC)CC,,val
US07375227B2,CCOC(=O)CN=C=O.Cc1cc(N)c2ccccc2n1>>CCOC(=O)CNC(=O)Nc1cc(C)nc2ccccc12,,C1CCOC1,,,,val
US05663185,COC(=O)C(=O)c1sccc1C.O=C1CCC(=O)N1Br>>COC(=O)C(=O)c1sccc1CBr,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,,,val
US20110009432A1,COc1ccc([C@H](N)CCO)cn1.Cc1ccc(N2CCc3ncnc(Cl)c3C2)nc1>>COc1ccc([C@@H](CCO)Nc2ncnc3c2CN(c2ccc(C)cn2)CC3)cn1,,CC#N,,CCN(C(C)C)C(C)C,,val
US04215139,CCOC(=O)NCCCl.O=C(c1ccccc1)c1ccc(O)cc1>>CCOC(=O)NCCOc1ccc(C(=O)c2ccccc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110237573A1,CC1(C)OB(c2ccc(N)nc2)OC1(C)C.Clc1cccnn1>>Nc1ccc(-c2cccnn2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20060178400A1,CC(N)C#Cc1cnc(Oc2ccc(Oc3ccccc3)cc2)s1.COC(=O)Cl>>COC(=O)NC(C)C#Cc1cnc(Oc2ccc(Oc3ccccc3)cc2)s1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US05318720,CC(=O)c1ccc(O)cc1.O=[N+]([O-])O>>CC(=O)c1ccc(O)c([N+](=O)[O-])c1,,O=S(=O)(O)O,,,,val
US04666835,BrCc1ccccc1.C=CC(C)C(NC(=O)OC(C)(C)C)C(=O)O>>C=CC(C)C(N)C(=O)OCc1ccccc1,,O=CO,,O=C([O-])O.[Na+],,val
US20100093788A1,O=C(Nc1ccc(-c2ccccc2F)cc1[N+](=O)[O-])C1=NOC2(CCOCC2)C1>>Fc1ccccc1-c1ccc2[nH]c(C3=NOC4(CCOCC4)C3)nc2c1,[Fe],CC(=O)O,,[Na+].[OH-],,val
US20070191405A1,Cc1c[nH]cn1.O=[N+]([O-])c1ccc(F)cc1>>Cc1cn(-c2ccc(N)cc2)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100152208A1,CCOC(=O)CBr.Fc1ccc(Br)c(OC2CCN(c3nc4nc(S)ncc4s3)CC2)c1.O>>CCOC(=O)CSc1nc2nc(N3CCC(Oc4cc(F)ccc4Br)CC3)sc2c(=O)[nH]1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160016948A1,CC(C)n1cc(C(=O)O)c2cnc(Br)cc21.N#CC1CCC(N)CC1>>CC(C)n1cc(C(=O)NC2CCC(C#N)CC2)c2cnc(Br)cc21,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05047404,CC(C)COc1ccccc1C(=N)N.CCOC(=O)c1nnc(SC)nc1Cl>>CSc1nnc2c(=O)[nH]c(-c3ccccc3OCC(C)C)nc2n1,,CCN(CC)CC,,Cl,,val
US20150065550A1,CCC[Mg]Br.O=CCc1ccccc1Br>>CCCC(O)Cc1ccccc1Br,,C1CCOC1,,,,val
US20140163025A1,COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccc(-c6c(C)noc6C)cc5C#N)ccc(F)c43)ccc21>>Cc1noc(C)c1-c1ccc(Oc2ccc(F)c3c2CC[C@H]3Oc2ccc3c(c2)OC[C@H]3CC(=O)O)c(C#N)c1,,CCO,,[K+].[OH-],,val
US05177095,CCCCC(=NNC(=O)c1ccccc1)OCC.CCCc1cc(CN)ccc1OC(C(=O)OC)c1ccccc1>>CCCCc1nnc(-c2ccccc2)n1Cc1ccc(OC(C(=O)OC)c2ccccc2)c(CCC)c1,,CCO,,ClC(Cl)Cl,,val
US20060166983A1,CCOC(=O)Cn1ccc2cc(O)ccc21.Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccc(C(F)(F)F)cc3)oc2C)cc1>>CCOC(=O)Cn1ccc2cc(OCCc3nc(-c4ccc(C(F)(F)F)cc4)oc3C)ccc21,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130231328A1,CCN(C(=O)OC(C)(C)C)C1CCC(Oc2ncnc3sc4c(c23)[C@@H](CC(N)=O)CC4)CC1>>CCNC1CCC(Oc2ncnc3sc4c(c23)[C@@H](CC(N)=O)CC4)CC1,,ClCCl,,Cl,,val
US05434289,C/C=C(/CC)O[Si](C)(C)C.CCCCOC(=O)C=O>>CC=C(O[Si](C)(C)C)C(C)C(O)C(=O)OCCCC,,ClCCl,,O=C([O-])O.[Na+],,val
US06329370B1,COC(=O)CCCc1nnc(-c2nccs2)c2cc(OC)ccc12>>COc1ccc2c(CCCC(=O)O)nnc(-c3nccs3)c2c1,,CO,,[Na+].[OH-],,val
US20100256363A1,CC1(C)C(=O)N(Br)C(=O)N1Br.CC[C@H](N)c1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>C[C@@H](NC(=O)C(F)(F)F)c1ccc(Br)cc1,,ClCCl,,CS(=O)(=O)O,,val
US20040048882A1,Cn1cncc1C(N)(c1ccc(C#N)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2C>>Cn1cncc1C(N)(c1ccc(CN)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2C,[Ni],CO,N,,,val
US20070082912A1,BrCc1ccccc1.CCOC(=O)c1ccnc(-n2c(C)ccc2-c2cc(Cl)ccc2O)c1>>CCOC(=O)c1ccnc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccccc2)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20040254215A1,COC(=O)CNC(=O)c1nc(Cl)c2ccccc2c1OC>>COc1c(C(=O)NCC(=O)O)nc(Cl)c2ccccc12,,CCO,,[K+].[OH-],,val
US03992389,O=C(NC1CCNCC1)c1ccccc1.OCCc1ccc2ccccc2c1>>O=C(NC1CCN(CCc2ccc3ccccc3c2)CC1)c1ccccc1,[Ni],Cc1ccccc1C,,,,val
US20030220368A1,COc1ncccc1CN1CCC(CC(=O)c2ccccc2N)CC1.CS(=O)(=O)Cl>>COc1ncccc1CN1CCC(CC(=O)c2ccccc2NS(C)(=O)=O)CC1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US06194461B1,CC(C)(C)[N+](=O)[O-].O=CC=Cc1ccccc1>>CC(C)(C)[N+]([O-])=CC=Cc1ccccc1,[Zn],CCO,,CC(=O)O,,val
US20050209249A1,CC(C)(C)OC(=O)N1CC(=O)C[C@H]1C(=O)N1CCSC1.COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1>>COC(=O)C=C1C[C@@H](C(=O)N2CCSC2)N(C(=O)OC(C)(C)C)C1,,ClCCl,,,,val
US20060205718A1,CCOC(=O)c1ccc(Cl)c(OCC)c1>>CCOc1cc(CO)ccc1Cl,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20120082646A1,COc1c(I)cc(I)cc1C(C)(C)C.Oc1ccccn1>>COc1c(I)cc(-n2ccccc2=O)cc1C(C)(C)C,[Cu]I,C1COCCO1,,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20130302416A1,CCOC(=O)c1n[nH]c2c1CCCc1cnc(Nc3ccc(Br)cc3OC)nc1-2.CI>>CCOC(=O)c1c2c(nn1C)-c1nc(Nc3ccc(Br)cc3OC)ncc1CCC2,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06403792B1,O=C(Nc1ccccc1)[C@H]1CCCN1>>c1ccc(NC[C@H]2CCCN2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100158996A1,Cc1ccc([N+](=O)[O-])c(C(=O)N(C)C)c1.O=C1CCC(=O)N1Br>>CN(C)C(=O)c1cc(CBr)ccc1[N+](=O)[O-],,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20150225412A1,CC(C)(C)OC(=O)N1CCCC1CN.O=Cc1ccc(F)c([N+](=O)[O-])c1>>CC(C)(C)OC(=O)N1CCCC1CNc1ccc(C=O)cc1[N+](=O)[O-],,CC#N,,CCN(C(C)C)C(C)C,,val
US20120220609A1,CON(C)C(=O)Cc1ccc(-c2ccc(Br)cc2)cc1.[Li]C>>CC(=O)Cc1ccc(-c2ccc(Br)cc2)cc1,,C1CCOC1,,CCOCC,O,val
US20100094000A1,CC1(C)OB(c2ccc3c(c2)NC(=O)CO3)OC1(C)C.Cc1nn(Cc2ccoc2)c(-c2ccc(F)cc2)c1Br>>Cc1nn(Cc2ccoc2)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2,,C1CCOC1,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04129654,CC(C)C(=O)OC(=O)C(C)C.Cn1c(NO)cc(=O)n(C)c1=O>>CC(C)c1onc2c1c(=O)n(C)c(=O)n2C,,Cc1ccccc1C,,,,val
US20020143212A1,C[C@H](N)c1ccccc1.O=Cc1cccc(OCc2ccccc2)c1>>C[C@H](N=Cc1cccc(OCc2ccccc2)c1)c1ccccc1,,COC(C)(C)C,,,,val
US20140243347A1,CCOC(=O)CC1CNC(=O)c2cc(-c3cccc(Cl)c3)c(I)n21>>O=C(O)CC1CNC(=O)c2cc(-c3cccc(Cl)c3)c(I)n21,,CCO,O,[Li+].[OH-],,val
US20090042726A1,CCOC(=O)c1ccc(C(F)(F)F)nc1C>>Cc1nc(C(F)(F)F)ccc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050261269A1,CCOC1([N+](=O)[O-])C=CC(NC(=O)COc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)=CC1>>CCOC1([N+](=O)[O-])C=CC(NCCOc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)=CC1,,C1CCOC1,,CO,,val
US20150361081A1,COc1ccc(CN2CCn3nc(CN(C(=O)C(F)(F)F)c4ccc(OC(F)F)cc4F)cc3C2=O)cc1>>O=C1NCCn2nc(CN(C(=O)C(F)(F)F)c3ccc(OC(F)F)cc3F)cc21,,CC#N,O,,,val
US05728686,C1=COCCC1.CCOP(=O)(CCCCCO)OCC>>CCOP(=O)(CCCCCOC1CCCCO1)OCC,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20120101100A1,CCNC(=O)Nc1cc(-c2nc(-c3ccccn3)cs2)c(B(O)O)cn1.Cc1nnc(-c2cncc(Br)c2)o1>>CCNC(=O)Nc1cc(-c2nc(-c3ccccn3)cs2)c(-c2cncc(-c3nnc(C)o3)c2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04804665,N#CCCl.O=C(OCc1ccccc1)N1CCC2(CC1)CC(=O)N(O)C2=O>>N#CCON1C(=O)CC2(CCN(C(=O)OCc3ccccc3)CC2)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20020052410A1,O=[Cr](=O)=O.OC(CCc1ccccc1)c1ccccc1>>O=C(Cc1ccccc1)Cc1ccccc1,,CC(C)=O,,O=S(=O)(O)O,,val
US20040209905A1,CCCNC(=O)Nc1ccc(Oc2ccnc3cc(OCCBr)c(OC)cc23)cc1Cl.CN1CCNCC1>>CCCNC(=O)Nc1ccc(Oc2ccnc3cc(OCCN4CCN(C)CC4)c(OC)cc23)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130184253A1,CCn1nc(C2CC2)cc1N1CCc2nc(-c3c(C)ccc4c3c(C)nn4S(=O)(=O)c3ccc(C)cc3)nc(N3CCOC[C@H]3C)c2C1.O=C1CCC(=O)N1Cl>>CCn1nc(C2CC2)c(Cl)c1N1CCc2nc(-c3c(C)ccc4c3c(C)nn4S(=O)(=O)c3ccc(C)cc3)nc(N3CCOC[C@H]3C)c2C1,,ClCCl,,,,val
US20100029689A1,CC(C)(C)OC(=O)c1ccc(N)cc1.O=Cc1cccnc1>>CC(C)(C)OC(=O)c1ccc(NCc2cccnc2)cc1,,CC(Cl)Cl,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04460782,COC1CC(=O)OC1=O.Nc1cc(Cl)cc(Cl)c1>>COC(CC(=O)O)C(O)=Nc1cc(Cl)cc(Cl)c1,,Cc1ccccc1C,,,,val
US20060084663A1,CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)nc1C(C)C>>CC(C)c1nc(-c2ccc(C(F)(F)F)cc2)sc1C(=O)O,,C1CCOC1,,Cl,[Na+].[OH-],val
US20140350019A1,CCOC(=O)CBr.Oc1ccc(F)c(NCc2cccc(-c3cccc(F)c3)c2)c1F>>CCOC(=O)COc1ccc(F)c(NCc2cccc(-c3cccc(F)c3)c2)c1F,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04640913,C1CCOCC1.COC(=O)[C@H](CO)NC(C)=O>>COC(=O)[C@H](COC1CCCCO1)NC(C)=O,,ClCCl,,,,val
US20100056515A1,CC(C)OC(=O)CBr.CCC(CC)c1cccc2c1[nH]c(=O)n2C(=O)OC(C)(C)C>>CCC(CC)c1cccc2[nH]c(=O)n(CC(=O)OC(C)C)c12,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100240671A1,CC(C)Oc1ccc(C[C@@H](C#N)NC(=O)OC(C)(C)C)cc1>>CC(C)Oc1ccc(C[C@H](N)C#N)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150166564A1,CCBr.Cc1c(N)n(-c2cnccn2)[nH]c1=O>>CCOc1nn(-c2cnccn2)c(N)c1C,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080058521A1,CCOc1ccc(B(O)O)cc1C=O.CN(C(=O)OC(C)(C)C)[C@@H]1CC[C@@H](N)CC1>>CCOc1ccc(B(O)O)cc1CNC1CCC(N(C)C(=O)OC(C)(C)C)CC1,,C1CCOC1,Cc1ccccc1,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100261698A1,N#Cc1ccc2[nH]c(-c3cccnc3)cc2c1.N#Cc1cccc(S(=O)(=O)Cl)c1>>N#Cc1cccc(S(=O)(=O)n2c(-c3cccnc3)cc3cc(C#N)ccc32)c1,,CN(C)C=O,,[H-].[Na+],,val
US20030092694A1,CC(C)(C)OC(=O)N1CCN(c2nccnc2Cl)CC1.OCCS>>CC(C)(C)OC(=O)N1CCN(c2nccnc2SCCO)CC1,,C1COCCO1,O,[Na+].[OH-],,val
US04028379,COc1cccnc1CSCCN.CSC(=C[N+](=O)[O-])S(C)=O>>COc1cccnc1CSCCNC(=C[N+](=O)[O-])SC,,CO,,,,val
US06140332,COc1ccc(-c2[nH]c3ncnc(Cl)c3c2C)cc1.Nc1cccc(Cl)c1>>COc1ccc(-c2[nH]c3ncnc(Nc4cccc(Cl)c4)c3c2C)cc1,,CCCCO,,,,val
US05140031,N#CN.S=C=Nc1cccc(Cl)c1>>N#CNC(=S)Nc1cccc(Cl)c1,,CCO,,[Na],,val
US04259297,Cl.O.O=S([O-])O.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].[Na+].[Na+].[Na+]>>O=S(=O)([O-])[O-].[Cl-].[Cr+3].[Na+].[Na+].[Na+].[OH-].[OH-].[OH-],,O,,,,val
US04163743,O=C(OO)c1cccc(Cl)c1.c1ccncc1>>O=C1CCN1Cc1ccccc1,,ClCCl,,O,,val
US20080139639A1,CN(Cc1cc(-c2ccccc2)n(S(=O)(=O)c2cccnc2Cl)c1)C(=O)OC(C)(C)C.Cl>>CNCc1cc(-c2ccccc2)n(S(=O)(=O)c2cccnc2Cl)c1.Cl,,CCOC(C)=O,,,,val
US20050209226A1,CCCCC1CCCNC1.O=C1COc2ccccc2N1CCCCl>>CCCCC1CCN(CCCN2C(=O)COc3ccccc32)CC1,,CC#N,CO,[I-].[K+],O=C([O-])O.[Na+],val
US20090270350A1,COc1cccc(CN)c1.Cc1cc(O)cc(=O)o1>>COc1cccc(Cn2c(C)cc(O)cc2=O)c1,,O,,,,val
US20120122842A1,NN.Nc1ccc(C(=O)C2=C(C(=O)O)CCCC2)cc1>>Nc1ccc(-c2n[nH]c(=O)c3c2CCCC3)cc1,,CCO,,O,,val
US04294960,C#CCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12)c1csc(NC=O)n1>>C#CCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12)c1csc(N)n1,,CO,,Cl,,val
US04018790,CCO.CN(C)S(=O)(=O)n1c(N)nc2cc(C(=O)NN)ccc21>>CN(C)S(=O)(=O)n1c(N)nc2cc(C(N)=O)ccc21.O,[Ni],CCO,,,,val
US20040266815A1,CC(C)(C)n1nc(C2CCC2)cc1N.COC(=O)CC(C)=O>>Cc1cc(=O)[nH]c2c1c(C1CCC1)nn2C(C)(C)C,,CC(=O)O,,,,val
US06723724B2,FC(F)(F)c1ccccc1CN1CCNCC1.O=CCCc1cc(-c2cccc([N+](=O)[O-])c2)no1>>O=[N+]([O-])c1cccc(-c2cc(CCCN3CCN(Cc4ccccc4)CC3)on2)c1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110257175A1,CCOC(Cn1cnc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)c1)OCC.NC1CC1.O=C(Cl)Oc1ccccc1>>CCOC(Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)c1)OCC,,CN(C)C=O,,c1ccncc1,,val
US20070213321A1,N#CBr.O=C(CNc1nc2ccccc2s1)N1CCCc2ccccc21>>N#CN(CC(=O)N1CCCc2ccccc21)c1nc2ccccc2s1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20020173646A1,COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1O.ClCCl.O=C1COCC(=O)N1CCO>>COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCN1C(=O)COCC1=O.Cl,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130317066A1,CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)O.O=S(Cl)Cl>>CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Cl,CN(C)C=O,Cc1ccccc1,,,,val
US20060035908A1,O=C(Nc1cccc(F)c1)Nc1ncc(CCN2C(=O)c3ccccc3C2=O)s1>>NCCc1cnc(NC(=O)Nc2cccc(F)c2)s1,,CCO,,NN,,val
US20080132502A1,CC(=O)Nc1nc(C)c(-c2cnnc(Cl)c2)s1.NS(=O)(=O)c1ccccc1>>CC(=O)Nc1nc(C)c(-c2cnnc(NS(=O)(=O)c3ccccc3)c2)s1,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150225400A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1c(Br)ccnc1C1CC[C@]2(CCN(C)C2=O)N1>>Cc1c(Br)ccnc1[C@H]1CC[C@]2(CCN(C)C2=O)N1C(=O)OC(C)(C)C,,ClCCl,,,,val
US04767784,CC(C)N.c1ccc2c(OCC3CO3)cccc2c1>>CC(C)NCC(O)COc1cccc2ccccc12,,O,,,,val
US04496558,CN1CCc2cccc(Cl)c2CC1.N#CBr>>N#CN1CCc2cccc(Cl)c2CC1,,Cc1ccccc1,,,,val
US20070043028A1,CCNCCO.CC[Si](Cl)(CC)CC>>CCNCCO[Si](CC)(CC)CC,,ClCCl,,c1c[nH]cn1,,val
US03948928,CCOC(Cc1noc2ccccc12)=NO.N>>NC(Cc1noc2ccccc12)=NO,,CCO,,,,val
US05200417,COc1cc2ccnc(Cl)c2cc1OC.COc1ccccc1CN>>COc1ccccc1CNc1nccc2cc(OC)c(OC)cc12.Cl,,ClC(Cl)Cl,,,,val
US20100076074A1,CCCC(C)(CO)CO.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCC1(C)COC(=O)OC1,,C1CCOC1,,CCN(CC)CC,,val
US20150005279A1,CC(C)(C)OC(=O)N1CCC[C@@H](N)C1.CCOC(OCC)OCC.Nc1ccc(F)cc1C(=O)O>>CC(C)(C)OC(=O)N1CCC[C@@H](n2cnc3ccc(F)cc3c2=O)C1,,C1CCOC1,O,,,val
US04629732,CC(C)(SC(F)(F)F)C(=O)C(Oc1ccc(Cl)cc1)n1cncn1>>CC(C)(SC(F)(F)F)C(O)C(Oc1ccc(Cl)cc1)n1cncn1,,CO,,O,[BH4-].[Na+],val
US20050026987A1,CCOC(=O)c1cc2c(ccc3ccccc32)[nH]1>>O=C(O)c1cc2c(ccc3ccccc32)[nH]1,,CCO,,[K+].[OH-],,val
US20130289016A1,CC(C)(C)OC(=O)N1CCC(NCCCO)CC1.COc1cccc2c1nc(C(F)F)n2-c1nc(Cl)nc(N2CCOCC2)n1>>COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N(CCCO)C2CCN(C(=O)OC(C)(C)C)CC2)n1,,CN(C)C=O,,,,val
US09409895B2,O=C(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)NCc1cn(Cc2ccccc2)nn1>>O=C(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)NCc1c[nH]nn1,,CCO,,[H][H],,val
US20120115813A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=Cc1c(F)ccc(OCCCOCc2ccccc2)c1OS(=O)(=O)C(F)(F)F>>CC1(C)OB(c2c(OCCCOCc3ccccc3)ccc(F)c2C=O)OC1(C)C,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20020012977A1,CC(=O)OCCOc1cc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)on1.O=C1CCC(=O)N1I>>CC(=O)OCCOc1noc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1I,,C1CCOC1,,,,val
US20130116243A1,COCCc1nnc2n1-c1cc(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)nc1OC2>>COCCc1nnc2n1-c1cc(-c3ccccc3)c(-c3ccc(C4(N)CCC4)cc3)nc1OC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120046292A1,CCOC(=O)[C@@H]1CC[C@H](Oc2ccc(C(=O)NCCNC(=O)c3ccc(O)cc3)cc2)CC1.Clc1ccccc1CBr>>CCOC(=O)[C@@H]1CC[C@H](Oc2ccc(C(=O)NCCNC(=O)c3ccc(OCc4ccccc4Cl)cc3)cc2)CC1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04574156,O=C(O)C(O)C(O)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O>>O=C([O-])C(O)C(O)C(=O)[O-].O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-],,CCO,,,,val
US20040019209A1,NN.O=C(CN1C(=O)CSC1=O)c1ccc(Cl)cc1>>O=C1NCC(c2ccc(Cl)cc2)=NN1,,CO,,O,,val
US20150336928A1,CC1(Cc2ncco2)C(=O)N(C2CCNCC2)c2ccccc21.c1cc2c3c(cccc3c1)C1OC21>>CC1(Cc2ncco2)C(=O)N(C2CCN(C3c4cccc5cccc(c45)C3O)CC2)c2ccccc21,,CN(C)C=O,,O,,val
US20100179168A1,Cc1ccc(B2OC(C)(C)C(C)(C)O2)o1.Nc1ccc(Cl)c(NS(=O)(=O)c2ccc(Br)c(F)c2)c1>>Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N)ccc3Cl)cc2F)o1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20080194549A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN(C)S(=O)(=O)Cc2ccccc2)C(C)C)ccc1OC>>COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2CN(C)S(=O)(=O)Cc2ccccc2)C(C)C)ccc1OC,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US04499094,CCNCC.O=C(O)c1cc2ccsc2c(-c2ccccc2Cl)n1>>CCN(CC)C(=O)c1cc2ccsc2c(-c2ccccc2Cl)n1,,ClC(Cl)Cl,,CCN(CC)CC,CCOC(=O)Cl,val
US20160244414A1,CN(C)C=NC(=O)c1nn(-c2ccccc2)c(=O)cc1Sc1ccccc1.NN>>O=c1cc(Sc2ccccc2)c(-c2nc[nH]n2)nn1-c1ccccc1,,CC(=O)O,,O,,val
US04923970,CNC(=O)N(C)N=NCCO[Si](C)(C)C(C)(C)C>>CNC(=O)N(C)N=NCCO,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110046145A1,CC(C)(C)OC(=O)N1CCc2ccccc2C1C(=O)O.CI.Cl>>COC(=O)C1NCCc2ccccc21.Cl,,CCOC(C)=O,CN(C)C=O,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20130059849A1,CCOC(=O)c1cc(-c2ccc(OC)cc2)nc2c1cnn2C(C)C>>COc1ccc(-c2cc(C(=O)O)c3cnn(C(C)C)c3n2)cc1,,C1CCOC1,,CCO,[Na+].[OH-],val
US04666933,CC(C)CCON=O.Cc1cc(=O)n(C)[nH]1>>CC1NN(C)C(=O)C1=NO,,CCO,,C[O-].[Na+],,val
US20060160904A1,CS(=O)(=O)Cl.O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(CC[C@H](O)CO)ccc1Cl>>CS(=O)(=O)OC[C@@H](O)CCc1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1,,ClCCl,,CCN(CC)CC,,val
US20130210809A1,COc1ccc(Cn2cc(C(=O)CBr)c(Br)n2)cc1.NC(=S)Nc1ncccn1>>COc1ccc(Cn2cc(-c3csc(Nc4ncccn4)n3)c(Br)n2)cc1,,CCO,,,,val
US20160228450A1,CCCCC1=CC(=O)N(C2CCN(C(=O)OCc3ccccc3)CC2)CC1>>CCCCC1CCN(C2CCNCC2)C(=O)C1,[Pd],CO,,,,val
US20160176861A1,O=C1C[C@H]2CC3(C[C@H]2C1)OCCO3>>OC1C[C@H]2CC3(C[C@H]2C1)OCCO3,,CO,,[BH4-].[Na+],,val
US04273932,CCOC(=O)c1cnc2c(c1O)C(=O)CCC2>>O=C(O)c1cnc2c(c1O)C(=O)CCC2,,O,,Cl,[Na+].[OH-],val
US20030032623A1,NCC=Cc1ccnc2ccccc12>>NCCCc1ccnc2ccccc12,[Pd],CO,,,,val
US06096930,Cc1cc(Cl)c2c(c1C)C(=O)C(C)(C)C2=O>>Cc1cc(Cl)c2c(c1C)CC(C)(C)C2,,CCO,Cl,c1ccccc1,,val
US20120165309A1,Cc1ccc(S(=O)(=O)OCC(C)F)cc1.N[C@@H]1CC[C@@H](CNc2nc(N3CCOCC3)cc(-n3c(C(F)F)nc4ccccc43)n2)CC1.O=C([O-])[O-]>>CC1CN([C@@H]2CC[C@@H](CNc3nc(N4CCOCC4)cc(-n4c(C(F)F)nc5ccccc54)n3)CC2)C(=O)O1,,CC(=O)N(C)C,,O,,val
US05312829,CC(C)Cc1ccc(C(Cc2ccc(C(=O)O)cc2)c2ccc(CC(C)C)cc2)cc1.O=C(Cl)C(=O)Cl>>CC(C)Cc1ccc(C(Cc2ccc(C(=O)Cl)cc2)c2ccc(CC(C)C)cc2)cc1,,ClCCl,,CN(C)C=O,,val
US20110105461A1,CC(=O)Oc1cc(S(=O)(=O)C(F)(F)F)ccc1OC[C@H]1CO1>>O=S(=O)(c1ccc2c(c1)O[C@@H](CO)CO2)C(F)(F)F,,C1COCCO1,,[K+].[OH-],,val
US20070043026A1,COc1cc2c(cc1NS(=O)(=O)c1ccc(CNc3ccc(F)cc3)cc1)CCN(C(=O)OC(C)(C)C)CC2.Cl>>COc1cc2c(cc1NS(=O)(=O)c1ccc(CNc3ccc(F)cc3)cc1)CCNCC2.Cl,,CCOC(C)=O,,,,val
US20090292121A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1c(C2CCNCC2)cc(Cl)nc1Cl>>CC(C)(C)OC(=O)N1CCC(c2cc(Cl)nc(Cl)c2C#N)CC1,,ClCCl,,CCOC(C)=O,,val
US20070254869A1,COC(=O)CCCN(C(=O)OC(C)C)c1cc(Cl)c(Br)cc1C(=O)OC>>COC(=O)C1CCN(C(=O)OC(C)C)c2cc(Cl)c(Br)cc2C1=O,,CCOC(C)=O,Cc1ccccc1,CC(C)(C)[O-].[K+],,val
US03932428,CS(=O)(=O)Cl.On1c(C(F)(F)F)nc2ncc(Cl)cc21>>CS(=O)(=O)On1c(C(F)(F)F)nc2ncc(Cl)cc21,,c1ccncc1,,Cl,,val
US20060281771A1,CC(C)(C)OC(=O)N1CCC(CO)CC1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)N1CCC(COC(=O)n2ccnc2)CC1,,ClCCl,,,,val
US20100197655A1,CC=O.N#Cc1cc(S(=O)(=O)Nc2cscn2)ccc1Oc1ccc(Cl)cc1-c1ccnn1C1CNC1>>CCN1CC(n2nccc2-c2cc(Cl)ccc2Oc2ccc(S(=O)(=O)Nc3cscn3)cc2C#N)C1,,CO,ClCCl,CCN(CC)CC,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140323435A1,CC(C)(C)OC(=O)NCCO.Clc1nc(-c2ccncc2)nc2sc3c(c12)CCCC3>>CNCCOc1nc(-c2ccncc2)nc2sc3c(c12)CCCC3,,CC(=O)N(C)C,O,[H-].[Na+],,val
US20160222030A1,CS(=O)(=O)Cl.[N-]=[N+]=N[C@@H]1COC[C@H]1O>>CS(=O)(=O)O[C@@H]1COC[C@H]1N=[N+]=[N-],,ClCCl,,c1ccncc1,O=C([O-])O.[Na+],val
US20090099176A1,COC(=O)C(=Cc1cnccc1NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C>>COC(=O)C(Cc1cnccc1NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C,[Pd],CCO,,,,val
US20160083368A1,Cc1c(-c2ccc(C#CC3(O)CCOCC3)nc2[C@H](Cc2cc(F)cc(F)c2)NC(=O)OC(C)(C)C)ccc2n[nH]c(=O)n12>>Cc1c(-c2ccc(C#CC3(O)CCOCC3)nc2[C@@H](N)Cc2cc(F)cc(F)c2)ccc2n[nH]c(=O)n12,,ClCCl,,O=C(O)C(F)(F)F,,val
US04546104,CCOC=C(C#N)C#N.NNCc1ccccc1>>N#Cc1cnn(Cc2ccccc2)c1N,,CCO,,CCCCCC,CCOC(C)=O,val
US20160083368A1,C[Si](C)(C)C#CC1(O)CC(F)(F)C1>>C#CC1(O)CC(F)(F)C1,,CCOCC,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110028390A1,CC(=O)C=O.CC(C)NN>>CC(=O)C=NNC(C)C,,O,,CC(=O)O,Cl,val
US04505913,CC(C)NS(=O)(=O)c1ccc2[nH]c(=O)oc(=O)c2c1.CN1CCNCC1>>CC(C)NS(=O)(=O)c1ccc(N)c(C(=O)N2CCN(C)CC2)c1,,CCOCC,ClCCl,,,val
US20090286779A1,C#CC(=O)OC.COc1ccc(-c2cn[nH]c2N)cc1OC>>COc1ccc(-c2cnn3ccc(=O)[nH]c23)cc1OC,,C1COCCO1,,,,val
US20120190724A1,COc1cccc2c(=O)c3c(O)cc(OCC4CS4)cc3oc12.Cl>>COc1cccc2c(=O)c3c(O)cc(OCC(S)CCl)cc3oc12,,CCOC(C)=O,,,,val
US20120077948A1,C#CCCC(=O)NCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)O.O=C(O)C(F)(F)F>>C#CCCC(=O)NCCCC[C@H](N)C(=O)O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20090312381A1,COC(=O)Cn1nc(-c2ccc(Cl)cc2)n(CCCC(=O)OC(C)(C)C)c1=O>>CC(C)(C)OC(=O)CCCn1c(-c2ccc(Cl)cc2)nn(CC(=O)O)c1=O,,CO,,O,[Li+].[OH-],val
US20100004292A1,CC(C)(C)[Si](C)(C)OCCN(C#N)c1ccc(NC(=O)c2ncccc2NC(=O)c2ccc(Cl)s2)cc1.CS(=O)(=O)O>>CS(=O)(=O)O.N=C1OCCN1c1ccc(NC(=O)c2ncccc2NC(=O)c2ccc(Cl)s2)cc1,,CCOCC,,,,val
US20050148627A1,C[Al](C)C.C[Si](C)(C)CCOCOc1cccc(C(=O)c2ccccc2)c1>>C=C(c1ccccc1)c1cccc(O)c1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,Cl,O,val
US20030176454A1,O=P(Cl)(Cl)Cl.Oc1ncnc2c1CCc1ccsc1-2>>Clc1ncnc2c1CCc1ccsc1-2,,CCOC(C)=O,,Cc1ccccc1,,val
US20120302756A1,CC(C)(C)[S@](=O)/N=C(\CCCCl)c1cccs1>>CC(C)(C)[S@](=O)N1CCC[C@@H]1c1cccs1,,CO,,,,val
US20100124550A1,COCCCOc1cc(C(O)[C@@H](C/C=C/C[C@H](C(=O)N(C)C)C(C)C)C(C)C)ccc1OC>>COCCCOc1cc(C[C@@H](C/C=C/C[C@H](C(=O)N(C)C)C(C)C)C(C)C)ccc1OC,,ClCCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20050267170A1,COC(=O)c1cc(Cl)ccc1CBr.Oc1cncc(F)c1>>COC(=O)c1cc(Cl)ccc1COc1cncc(F)c1,,CN(C)C=O,,[H-].[Na+],,val
US20160122359A1,C[C@@H](OCc1ccccc1)[C@H](NC(=O)C1(CO)CCCN1C(=O)OC(C)(C)C)C(=O)OCc1ccccc1>>C[C@@H](OCc1ccccc1)[C@@H](C(=O)OCc1ccccc1)N1CC2(CCCN2C(=O)OC(C)(C)C)C1=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160024044A1,CN(C[C@H](c1ccc2ccccc2c1)[C@H](O)c1ccccc1)C(=O)OC(C)(C)C>>CN(C)C[C@H](c1ccc2ccccc2c1)[C@H](O)c1ccccc1,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20030171369A1,COC(=O)CC1CN(CCSc2cc(F)ccc2F)CCC1CCC(=O)c1c(F)cnc2ccc(OC)cc12.NO>>COC(=O)CC1CN(CCSc2cc(F)ccc2F)CCC1CCC(=NO)c1c(F)cnc2ccc(OC)cc12,,c1ccncc1,,Cl,,val
US20040162442A1,C/C=C/C(=O)O.C[Si](C)(C)Cl>>C/C=C/C(=O)O[Si](C)(C)C,,CCOCC,,c1ccncc1,,val
US05443970,CC(C)(C)[Si](C)(C)OCc1cc(O)cc(=O)o1>>CC(C)(C)[Si](C)(C)OCC1CC(O)=CC(=O)O1,,CCO,,,,val
US20120040953A1,CC(C)(C)OC(=O)N[C@H]1CN(c2ncc(Br)cn2)C[C@@H]1N1CCCCC1=O.CC(C)OC(=O)N1CCC(C(C)Oc2ccc(B3OC(C)(C)C(C)(C)O3)cn2)CC1>>CC(C)OC(=O)N1CCC([C@H](C)Oc2ccc(-c3cnc(N4C[C@H](NC(=O)OC(C)(C)C)[C@@H](N5CCCCC5=O)C4)nc3)cn2)CC1,,O,,CCN(CC)CC,CN(C)C=O,val
US20150232459A1,COC(=O)NCCCn1nc([C@@H](C)N(C(=O)[C@H]2CN[C@@H](CO)CO2)C2CC2)c2ccc(C)nc21.O=Cc1ccccc1>>COC(=O)NCCCn1nc([C@@H](C)N(C(=O)[C@H]2CN(Cc3ccccc3)[C@@H](CO)CO2)C2CC2)c2ccc(C)nc21,,ClCCl,,O=C([O-])O.[Na+],,val
US20120214803A1,CN(C)CCN.CN1C(c2ccc(F)c(C=O)c2)c2ccc3cccnc3c2NS1(=O)=O>>CN(C)CCNCc1cc(C2c3ccc4cccnc4c3NS(=O)(=O)N2C)ccc1F,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140296245A1,CC(C)(C)OC(=O)N1CC[C@@H](c2ccc(Cl)cc2)[C@H](COc2cc(F)c(S(N)(=O)=O)cc2F)C1.O=C(Cl)c1ccccn1>>CC(C)(C)OC(=O)N1CC[C@@H](c2ccc(Cl)cc2)[C@H](COc2cc(F)c(S(=O)(=O)NC(=O)c3ccccn3)cc2F)C1,,CC#N,CCOC(C)=O,CCN(CC)CC,Cl,val
US06001839,CC(C)n1cc(-c2ccc(NS(=O)(=O)c3ccccc3)cc2)c2c(Cl)ncnc21.N>>CC(C)n1cc(-c2ccc(NS(=O)(=O)c3ccccc3)cc2)c2c(N)ncnc21,,C1COCCO1,,,,val
US06492403B1,CCn1c2ccccc2c2cc(N)ccc21.COC(=S)c1cc(Br)c(C)s1>>CCn1c2ccccc2c2cc(Nc3cc(C(=S)OC)sc3C)ccc21,,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1,O=C([O-])[O-].[Cs+].[Cs+],val
US20060041137A1,CC(C)C(=O)Cl.CCCC1=NNC(=O)/C1=C1/C=C(Sc2ccc(N)cc2)c2ccccc2N1>>CCCC1=NNC(=O)/C1=C1/C=C(Sc2ccc(NC(=O)C(C)C)cc2)c2ccccc2N1,,C1CCOC1,,,,val
US04103022,Nc1ccc2c(c1)C(F)(F)OC(F)(F)O2.O=C=NC(=O)c1c(F)cccc1F>>O=C(NC(=O)c1c(F)cccc1F)Nc1ccc2c(c1)C(F)(F)OC(F)(F)O2,,Cc1ccccc1,,,,val
US20150225422A1,CC(=O)Nc1cc(-c2cnc(C)c(N)c2)ccn1.O=S(=O)(Cl)c1ccc(F)cc1Cl>>CC(=O)Nc1cc(-c2cnc(C)c(NS(=O)(=O)c3ccc(F)cc3Cl)c2)ccn1,,c1ccncc1,,,,val
US20120225062A1,CC1(C)OC[C@@H](CO)O1.C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C[C@@H](NC(=O)OC(C)(C)C)C1>>C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC[C@@H]4COC(C)(C)O4)cc3F)n2)C[C@@H](NC(=O)OC(C)(C)C)C1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060004013A1,CCOP(=O)(OCC)C(CCCCl)C(=O)OC(C)(C)C.COc1cc(C=O)c(F)cc1-n1cnc(C)c1>>COc1cc(/C=C(\CCCCl)C(=O)OC(C)(C)C)c(F)cc1-n1cnc(C)c1,,C1CCOC1,CCOC(C)=O,O,[H-].[Na+],val
US20130267729A1,CC(C)(C)OC(=O)N1CC(=O)OC1=O.NCC(F)(F)F>>CC(C)(C)OC(=O)NCC(=O)NCC(F)(F)F,,CCOC(C)=O,,,,val
US20110144194A1,C#CCCCCCCCCCCOCc1ccccc1.COc1ccc(-c2oc3ccc(Br)cc3c(=O)c2O)cc1OC>>COc1ccc(-c2oc3ccc(C#CCCCCCCCCCCOCc4ccccc4)cc3c(=O)c2O)cc1OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCNCC1,,,,val
US20090264404A1,CC(=O)OC(C)=O.Cn1nc(N)cc1OCCCN1CCN(c2cccc3sccc23)CC1>>CC(=O)Nc1cc(OCCCN2CCN(c3cccc4sccc34)CC2)n(C)n1,,ClCCl,,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20060287327A1,CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)N1CCCOC1CCCO1>>CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)N1CCCO,,CCOC(C)=O,CO,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050049296A1,BrC(c1ccccc1)c1ccccc1.COC(=O)c1ccccc1OCCc1c(CCNC(C)=O)[nH]c2ccc(Cl)cc12>>COC(=O)c1ccccc1OCCc1c(CCNC(C)=O)n(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12,,CC#N,CCOC(C)=O,O,CC(C)(C)[O-].[K+],val
US20160068512A1,OC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc2ncnc(NC3CCN(c4ccccc4)CC3)c2c1>>Fc1ccc(C(c2ccc(F)cc2)c2ccc3ncnc(NC4CCN(c5ccccc5)CC4)c3c2)cc1,,ClCCl,ClCCl,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20100093757A1,COC(=O)[C@@H](O)COCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.Nc1ccccn1>>CC(C)(C)[Si](OCCOC[C@H](O)C(=O)Nc1ccccn1)(c1ccccc1)c1ccccc1,,Cc1ccccc1,,C[Al](C)C,,val
US05234946,O=S(Cl)Cl.OCc1cccc(CCc2ccccc2)c1>>ClCc1cccc(CCc2ccccc2)c1,,ClC(Cl)Cl,,,,val
US20110059954A1,CI.Cc1cc(C(=O)c2ccc(F)c(Br)c2)cc2oc(=O)[nH]c12>>Cc1cc(C(=O)c2ccc(F)c(Br)c2)cc2oc(=O)n(C)c12,,CN(C)C=O,,[H-].[Na+],,val
US20110319380A1,O=c1c2ccc(Br)cc2nc2n1CCC1(CC2)OCCO1>>O=C1CCc2nc3cc(Br)ccc3c(=O)n2CC1,,C1CCOC1,,Cl,,val
US04362728,FC(F)(F)CN=C=S.Nc1ccnc(CCCCN2C(=O)c3ccccc3C2=O)n1>>O=C1c2ccccc2C(=O)N1CCCCc1nccc(NC(=S)NCC(F)(F)F)n1,,CC#N,,,,val
US20130089622A1,CSCCC(=O)N(C)c1sc(Cl)nc1Cl.OB(O)c1ccc(F)nc1>>CSCCC(=O)N(C)c1sc(-c2ccc(F)nc2)nc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20100324086A1,CCOC(=O)c1cccc(NC(=O)c2ccccc2C(F)(F)F)c1>>O=C(O)c1cccc(NC(=O)c2ccccc2C(F)(F)F)c1,,C1CCOC1,,[Na+].[OH-],,val
US04822787,CC(C)(C)[Si](C)(C)O[C@@H]1C[C@@H](CO)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1>>CC(C)(C)[Si](C)(C)O[C@H]1CN[C@H](CO)C1,[Pd],CO,,,,val
US20110045101A1,COc1cc(OC)cc(-n2cnc(C)c2-c2c(F)cc(OC)cc2F)c1.ClC(Cl)(Cl)C(Cl)(Cl)Cl>>COc1cc(OC)cc(-n2c(Cl)nc(C)c2-c2c(F)cc(OC)cc2F)c1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US05599813,CC1=C(C(=O)Cl)SC2=NCCCN21.Cl.Nc1cccnc1>>CC1=C(C(=O)Nc2ccccn2)SC2=NCCCN21.Cl.Cl,,c1ccncc1,,CN(C)c1ccccn1,,val
US20150038528A1,COC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O.C[C@@H](C(=O)OC(C)(C)C)[C@@H](C)N>>C[C@@H](C(=O)O)[C@@H](C)NC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O,,CCO,,CCN(CC)CC,,val
US20130184253A1,Cc1ccc(S(=O)(=O)n2cc(C)c3c(-c4nc5c(c(N6CCN[C@H](C)C6)n4)CN(c4cc(C(C)C)ccc4C)CC5)cccc32)cc1.O=C1COC1>>Cc1ccc(S(=O)(=O)n2cc(C)c3c(-c4nc5c(c(N6CCN(C7COC7)[C@H](C)C6)n4)CN(c4cc(C(C)C)ccc4C)CC5)cccc32)cc1,,CCOC(C)=O,ClCCl,,,val
US20040186301A1,CC(C)(C)OC(=O)CC(N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C.COC(=O)CBr>>COC(=O)N(C)C(CC(=O)OC(C)(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20050256198A1,CCCCCCCN(Cc1ccc(F)cc1F)C(=O)CCc1ccc(O)cc1.COC(=O)c1ccccc1CBr>>CCCCCCCN(Cc1ccc(F)cc1F)C(=O)CCc1ccc(OCc2ccccc2C(=O)OC)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04499094,CNC1CCCCC1.O=C(O)c1cc2ccccc2c(-c2ccccc2Cl)n1>>CN(C(=O)c1cc2ccccc2c(-c2ccccc2Cl)n1)C1CCCCC1,,ClC(Cl)Cl,,CCN(CC)CC,CCOC(=O)Cl,val
US05334740,CO.COCOC1CC2=CC(O)OCC2C2OC(C)(C)OC12>>COCOC1CC2=CC(OC)OCC2C(O)C1O,,CO,,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US20030186989A1,CCOC(=O)c1cccnc1Cl.Oc1ccc2nsnc2c1>>CCOC(=O)c1cccnc1Oc1ccc2nsnc2c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05192766,COC(=O)/C=C(/C#Cc1ccccc1)c1ccccc1>>O=C(O)/C=C(/C#Cc1ccccc1)c1ccccc1,,C1CCOC1,,CO,[Na+].[OH-],val
US20120157428A1,Cc1noc(COS(C)(=O)=O)c1-c1ccccc1C(=O)c1ccc(Cl)cc1.[N-]=[N+]=[N-]>>Cc1noc(CN=[N+]=[N-])c1-c1ccccc1C(=O)c1ccc(Cl)cc1,,O,,CN(C)C=O,,val
US20130190338A1,CC(C)(C)OC(=O)CNC(=O)c1ccc(CSc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1>>O=C(O)CNC(=O)c1ccc(CSc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1,,O=CO,,,,val
US20150259354A1,C=CC(=O)Cl.NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1NCCC2c1cccc(N)c1>>C=CC(=O)Nc1cccc(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)c1,,ClCCl,,c1ccncc1,,val
US04113869,COc1ccc2c(c1)CN(C)C(C)C2(O)c1ccccc1>>COc1ccc2c(c1)CN(C)C(C)C2c1ccccc1,,Cl,,,,val
US20020161150A1,CC(=O)OC(C)=O.COCCCCC(O)C1CC2C=CC1C2>>COCCCCC(OC(C)=O)C1CC2C=CC1C2,CN(C)c1ccncc1,c1ccncc1,,O,,val
US20050059687A1,CCOP(=O)(OCC)C(C)C(=O)OC.O=C1CCN(Cc2ccccc2)CC1>>COC(=O)C(C)=C1CCN(Cc2ccccc2)CC1,,C1CCOC1,,[H-].[Na+],,val
US04742060,CC(C)Br.O=[N+]([O-])N=C1NCCN1Cc1ccc(Cl)nc1>>CC(C)N1CCN(Cc2ccc(Cl)nc2)C1=N[N+](=O)[O-],,CN(C)C=O,,[H][H],[H-].[Na+],val
US20050107362A1,NC1c2ccccc2CC1NC(=O)c1cc2cc(Cl)ccc2[nH]1.O=C(Cl)CCl.O=C(O)C(F)(F)F>>O=C(N[C@@H]1Cc2ccccc2[C@H]1NC[C@@H](O)CO)c1cc2cc(Cl)ccc2[nH]1,,ClCCl,,CCN(CC)CC,,val
US20140275179A1,CCOC(=O)c1c(-c2ccc(CC)cc2)nsc1C(C)(F)F>>CCc1ccc(-c2nsc(C(C)(F)F)c2CO)cc1,,Cc1ccccc1,,CC(C)C[AlH]CC(C)C,,val
US20120149677A1,O=Cc1cc(Cl)cnc1Oc1ccc2c(nnn2CC2CC2)c1Br>>OCc1cc(Cl)cnc1Oc1ccc2c(nnn2CC2CC2)c1Br,,CCO,,[BH4-].[Na+],,val
US20110183989A1,CC(C)(C)OC(=O)N1CCN2C(=O)N([C@@H]3C[C@H]3c3ccccc3)C(=O)C2C1>>O=C1C2CNCCN2C(=O)N1[C@@H]1C[C@H]1c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050214901A1,Nc1nc(F)nc2c1ncn2[C@@H]1O[C@@H](COC(=O)c2ccccc2)[C@@H](OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1>>Nc1nc(F)nc2c1ncn2[C@@H]1O[C@@H](CO)[C@@H](O)[C@H]1O,,CCO,,CC(=O)O,[K+].[OH-],val
US20070105810A1,NC(=O)CI.O=C(O)c1cncc(Br)c1>>NC(=O)C[n+]1cc(Br)cc(C(=O)O)c1.[I-],,CN(C)C=O,,,,val
US20080200431A1,Cn1nc(Cl)ccc1=O.O=C(O)C1CCNCC1>>Cn1nc(N2CCC(C(=O)O)CC2)ccc1=O,,CCO,O,CCN(CC)CC,[Na+].[OH-],val
US20130072470A1,Cc1ccc(S(=O)(=O)n2ccc3c2ncc2ncc([C@H]4CN(C(=O)NCC(F)(F)F)C[C@H]4C)n23)cc1>>C[C@@H]1CN(C(=O)NCC(F)(F)F)C[C@@H]1c1cnc2cnc3[nH]ccc3n12,,C1COCCO1,,[Na+].[OH-],,val
US20100152160A1,CN(C(=O)OC(C)(C)C)c1cc2c(cc1Cl)N(C(=O)OC(C)(C)C)CC(C(=O)N1CCC(C#N)(Cc3ccc(F)cc3)CC1)O2>>CNc1cc2c(cc1Cl)NCC(C(=O)N1CCC(C#N)(Cc3ccc(F)cc3)CC1)O2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050234048A1,CC(C)(C)OC(=O)N1CC=C(C#Cc2ccc3c(c2)NC(=O)CC(c2cccc(C#N)c2)=N3)CC1>>N#Cc1cccc(C2=Nc3ccc(C#CC4=CCNCC4)cc3NC(=O)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160002169A1,COc1ccc2c(n1)CCN[C@H]2C(=O)Nc1cc(F)c2c(c1)CCC2(C)C.O=C(C[C@H]1C[C@@H]1C(=O)O)OCc1ccccc1>>COc1ccc2c(n1)CCN(C(=O)[C@H]1C[C@@H]1CC(=O)OCc1ccccc1)[C@H]2C(=O)Nc1cc(F)c2c(c1)CCC2(C)C,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040009966A1,CCOC1OC(=O)CC1NC(=O)CN1CC(CNC(=O)c2ccccc2)=CCC(NC(=O)c2nccc3ccccc23)C1=O>>O=C(CN1CC(CNC(=O)c2ccccc2)=CCC(NC(=O)c2nccc3ccccc23)C1=O)NC1CC(=O)OC1O,,CC#N,O,O=C(O)C(F)(F)F,,val
US20140094474A1,COC(=O)c1ccn(C2CC2)n1>>O=C(O)c1ccn(C2CC2)n1,,C1CCOC1,O,[Li]O,,val
US20100069374A1,CC1(C)Oc2cc(NS(=O)(=O)CCl)c(O)cc2[C@H](NCCc2ccccc2)[C@H]1O>>CC1(C)Oc2cc3c(cc2C(NCCc2ccccc2)C1O)OCS(=O)(=O)N3,,CO,,[Na+].[OH-],[Cl-].[NH4+],val
US20020002158A1,CC(CNS(C)(=O)=O)c1ccc(Br)cc1.O=Cc1ccc(B(O)O)cc1>>CC(CNS(C)(=O)=O)c1ccc(-c2ccc(C=O)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O,O=C([O-])[O-].[K+].[K+],val
US04011218,N#Cc1ccncc1.NNC(=O)c1ccc(N)cc1>>Nc1ccc(-c2n[nH]c(-c3ccncc3)n2)cc1,,CO,,[Na],,val
US20150210684A1,Cn1ccnc1C(O)(c1ccccc1)C1CCNCC1.O=C(O)C(=O)c1c[nH]c2c(-n3ccnn3)ncc(F)c12>>Cn1ccnc1C(O)(c1ccccc1)C1CCN(C(=O)C(=O)c2c[nH]c3c(-n4ccnn4)ncc(F)c23)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20040048908A1,CCOC(=O)CP(=O)(OCC)OCC.Cc1noc(-c2ccccc2)c1C=O>>Cc1noc(-c2ccccc2)c1/C=C/C(=O)O,,CN(C)C=O,,Cl,[H-].[Na+],val
US20160206616A1,CCOC(=O)CC[C@H]1CCC(F)(F)CN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CC(F)(F)CC[C@@H]1CCC(=O)O,,CCO,,O,[Li]O,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(C(=O)C2C(=O)OC(C)(C)OC2=O)CC1.Nc1[nH]nc2cccc(OCC(F)(F)F)c12>>CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4c(OCC(F)(F)F)cccc4nn23)CC1,,CC#N,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20070270384A1,ClCCCOc1ccc2c(Cl)ncnc2c1.Nc1cc(CC(=O)O)[nH]n1>>Cl.O=C(O)Cc1cc(Nc2ncnc3cc(OCCCCl)ccc23)n[nH]1,,CN1CCCC1=O,,,,val
US20020193616A1,CCC(/C=C/CO[C@@H](C)C1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C)(CC)O[Si](CC)(CC)CC>>CCC(O)(/C=C/CO[C@@H](C)C1=CC[C@H]2C3=CC=C4C[C@@H](O)C[C@H](O)[C@]4(C)[C@H]3CC[C@]12C)CC,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090029976A1,CCOC(=O)COc1cc(OC)c(Cl)cc1C(O)C(C)C>>CCOC(=O)COc1cc(OC)c(Cl)cc1C(=O)C(C)C,O=[Mn]=O,ClCCl,,,,val
US06310056B1,CC(C)(C)C(=O)OCI.C[C@@H]1C(c2cn3cnc(C(=O)N(C)C)c3s2)=C(C(=O)[O-])N2C(=O)[C@H]([C@@H](C)O)[C@@H]12>>C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCOC(=O)C(C)(C)C)=C(c3cn4cnc(C(=O)N(C)C)c4s3)[C@H](C)[C@H]12,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20080287396A1,CC(C)(C)OC(=O)N1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1.CCOP(=O)(OCC)C(NC(=O)CBr)P(=O)(OCC)OCC>>CCOP(=O)(OCC)C(NC(=O)COC(=O)c1cn(C2CC2)c2cc(N3CCN(C(=O)OC(C)(C)C)CC3)c(F)cc2c1=O)P(=O)(OCC)OCC,,O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150376176A1,COC(=O)c1ccnc(Br)c1.Cc1c[nH]cn1>>COC(=O)c1ccnc(-n2cnc(C)c2)c1,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130172342A1,Cc1cccc(C)c1C#CCO>>Cc1cccc(C)c1CCCO,O=[Pt]=O,CCO,,,,val
US20110003807A1,CC1(C)OB(Cc2ccccc2)OC1(C)C.CCOC(=O)c1sc(-c2c(C)nn3ccccc23)nc1OS(=O)(=O)C(F)(F)F>>CCOC(=O)c1sc(-c2c(C)nn3ccccc23)nc1Cc1ccccc1,,COCCOC,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20030191156A1,c1ccc(COc2ccccc2-c2cocn2)cc1>>Oc1ccccc1-c1cocn1,[Pd],ClCCl,,,,val
US05112922,CCCCCCCCN.O=C(Cl)CCBr>>CCCCCCCCNC(=O)CCBr,,ClCCl,,O,c1ccncc1,val
US20090227625A1,COC(=O)C(C)(C)NC(=O)c1ccc2ccccc2c1C#CCCc1ccccc1>>CC(C)(NC(=O)c1ccc2ccccc2c1C#CCCc1ccccc1)C(=O)O,,C1CCOC1,CO,[Na+].[OH-],,val
US20100105702A1,Cn1cc(C(=O)Cl)c(C(F)F)n1.NCCc1ncc(Br)cn1>>Cn1cc(C(N)=O)cn1,,C1CCOC1,,CCN(CC)CC,,val
US20130045980A1,Clc1cc(Br)c2nccn2n1.c1cncc(B2OCCCO2)c1>>Clc1cc(-c2cccnc2)c2nccn2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20110086834A1,Brc1ccc2c(c1)NCC2.Nc1nccc(Cl)n1>>Nc1nccc(N2CCc3ccc(Br)cc32)n1,,C1COCCO1,,,,val
US03993657,BrBr.CC(=O)c1ccc(-c2ccc([N+](=O)[O-])cc2)o1>>O=C(CBr)c1ccc(-c2ccc([N+](=O)[O-])cc2)o1,,ClC(Cl)(Cl)Cl,,,,val
US05594023,CNC1(c2ccccc2Cl)C(=O)Nc2ccc(Cl)cc21.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CNC1(c2ccccc2Cl)C(=O)N(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)c2ccc(Cl)cc21,,ClCCl,,,,val
US04762838,CCOC(=O)c1ccc(Br)cc1N.Cl>>CCOC(=O)c1ccc(Br)cc1N.Cl,,CCOCC,,CCO,,val
US07179823B1,CCOC(=O)CCc1cn(Cc2ccc(OCc3cn4c(Cl)cccc4n3)cc2)nc1OCC.OB(O)c1ccccc1>>CCOC(=O)CCc1cn(Cc2ccc(OCc3cn4c(-c5ccccc5)cccc4n3)cc2)nc1OCC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20040034218A1,CI.O=C1CN=C(c2cccc(Cl)c2)c2cc(C(=O)c3ccc(Cl)cc3)ccc2N1>>CN1C(=O)CN=C(c2cccc(Cl)c2)c2cc(C(=O)c3ccc(Cl)cc3)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20120149694A1,CCO.O=C(N1CCOCC1)N1CC(CS(=O)(=O)[O-])CC(c2ccc(C(F)(F)F)cc2)C1>>CCOCC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1,,CN(C)C=O,,O,[H-].[Na+],val
US04808620,CC(C)(C)c1cccc(C(C)(C)C)c1O.Cc1cc(C)c(C(=O)Cl)c(Cl)n1>>Cc1cc(C)c(C(=O)c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)c(Cl)n1,,CC(Cl)Cl,,,,val
US04279912,CC(C)Oc1cc(N)nc2ccccc12.CCOC(=O)C(=O)CBr>>CCOC(=O)c1cn2c(cc(OC(C)C)c3ccccc32)n1,,COCCOC,,CCO,,val
US20020137736A1,COc1ccc(NC(=N)c2cccs2)cc1CO.O=S(Cl)Cl>>COc1ccc(NC(=N)c2cccs2)cc1CCl.Cl,,ClCCl,,CCOCC,,val
US20110152297A1,CN.COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1O[C@@H]1CCN(C(=O)OC(C)(C)C)[C@@H](C(=O)O)C1>>CNC(=O)[C@H]1C[C@H](Oc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)CCN1C(=O)OC(C)(C)C,,C1CCOC1,ClCCl,CN1CCOCC1,,val
US20120309750A1,CC#N.CCNC(=O)c1noc(-c2cc(C(C)C)c(OCc3ccccc3)cc2OCc2ccccc2)c1I>>CCNC(=O)c1noc(-c2cc(C(C)C)c(OCc3ccccc3)cc2OCc2ccccc2)c1C#N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,CCOC(C)=O,,val
US20090143352A1,COc1ccccc1-c1cn(S(=O)(=O)c2ccc(C)cc2)c2ncc(-c3cc(F)c(NCc4ccncc4)c(C(=O)N(C)C)c3)cc12>>COc1ccccc1-c1c[nH]c2ncc(-c3cc(F)c(NCc4ccncc4)c(C(=O)N(C)C)c3)cc12,,C1CCOC1,CO,[K+].[OH-],,val
US20100273806A1,CCOC(=O)CC1CCc2c1[nH]c1ccc(C(=N)NO)cc21.O=C(Cl)c1cc(OC(F)(F)F)cc(N2CCCC2)c1>>CCOC(=O)CC1CCc2c1[nH]c1ccc(-c3noc(-c4cc(OC(F)(F)F)cc(N5CCCC5)c4)n3)cc21,,C1COCCO1,,CCN(CC)CC,,val
US20090155168A1,BrBr.COc1ccccc1CN>>Br.COc1ccc(Br)cc1CN,,CC(=O)O,,CCOCC,,val
US04753933,CN(C)CCOc1ccc2ccc(N)nc2n1.O=C(O)c1ccccc1>>CN(C)CCOc1ccc2ccc(NC(=O)c3ccccc3)nc2n1,,CCOC(C)=O,,O,,val
US20120058989A1,CC(C)(C)OC(=O)N1CC[C@H](O)[C@H]1CC=O.CO>>C#CC[C@@H]1[C@@H](O)CCN1C(=O)OC(C)(C)C,,CO,ClCCl,CCOC(C)=O,,val
US20020045615A1,COc1cc(I)cc([N+](=O)[O-])c1.OB(O)c1ccccc1>>COc1cc(-c2ccccc2)cc([N+](=O)[O-])c1,c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd-4]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20100273744A1,BrP(Br)Br.Cc1cc([N+](=O)[O-])ccc1CO>>Cc1cc([N+](=O)[O-])ccc1CBr,,ClCCl,,O=C([O-])O.[Na+],,val
US20100317624A1,CCOC(=O)c1cn(CC)c2cc(F)c(I)cc2c1=O>>CCn1cc(C(=O)O)c(=O)c2cc(I)c(F)cc21,,CCO,,Cl,[Na+].[OH-],val
US20090197825A1,CCOC(=O)CCSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12>>Sc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US20120208798A1,CC(=O)N1c2ccc(Br)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.CC(C)(C)OC(=O)n1cc(B2OC(C)(C)C(C)(C)O2)cn1>>CC(=O)N1c2ccc(-c3cn[nH]c3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US05399699,CCOC(=O)c1[nH]c2ccc(OC)cc2c1SC(C)(C)C.ClCc1ccc(Cl)cc1>>CCOC(=O)c1c(SC(C)(C)C)c2cc(OC)ccc2n1Cc1ccc(Cl)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US06235731B1,Cl.ClC(Cl)Cl.O=C(CN1CCC(CNC(=O)C2=Cc3cnc4cccc(n34)S2)CC1)Nc1ccccc1>>Cl.Cl.O=C(CN1CCC(CNC(=O)C2=Cc3cnc4cccc(n34)S2)CC1)Nc1ccccc1,,CO,ClC(Cl)Cl,CCOC(C)=O,,val
US20160251339A1,COc1ccc(S(=O)(=O)Cl)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1.O=Cc1c[nH]c2cc(F)ccc12>>COc1ccc(S(=O)(=O)n2cc(C=O)c3ccc(F)cc32)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1,,C1CCOC1,,[H-].[Na+],,val
US20080070931A1,COCC#Cc1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1ccc(Cl)cc1>>COCCCc1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1ccc(Cl)cc1,[Pd],CCOC(C)=O,,,,val
US04128650,Oc1c2c3c(ccnc3c3ccccc13)CCC2>>Oc1c2c(c3nccc4c3c1CCC4)CCCC2,[Pt],CC(=O)O,,,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)[nH]c2nc(C)nn12.CCc1ccc(CO)cn1>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(Cc2ccc(CC)nc2)c2nc(C)nn12,,C1CCOC1,CCOC(C)=O,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20160184318A1,CCOC(=O)c1cnn(CC2(O)CCN(C(=O)/C=C/c3ccc(Cl)cc3Cn3nnc(C)n3)CC2)c1>>Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCC(O)(Cn3cc(C(=O)O)cn3)CC2)n1,,CCO,,[Na+].[OH-],,val
US20100298290A1,CN(C)Cc1nc(O)c2c(n1)CCC(C)(C)C2.O=P(Cl)(Cl)Cl>>CN(C)Cc1nc(Cl)c2c(n1)CCC(C)(C)C2,,ClC(Cl)Cl,,,,val
US20150203483A1,CCOC(=O)C(F)(F)Cl.CNC(=O)N1N=C(c2ccc(Br)cc2)c2cc(OC)c(O)cc2CC1C>>CNC(=O)N1N=C(c2ccc(Br)cc2)c2cc(OC)c(OC(F)F)cc2CC1C,,CN(C)C=O,,O,[Na+].[OH-],val
US20160122344A1,COCCCOc1cc(CC(=O)C(C)(C)CCl)ccc1OC.[NH4+]>>COCCCOc1cc(CC(N)C(C)(C)CCl)ccc1OC,,CO,,[BH3-]C#N.[Na+],,val
US20050209254A1,CC(C)(C)OC(=O)NCCCN.CN(C)C(=O)C(Br)c1nc2cc(Cl)ccc2c(=O)[nH]1>>CN(C)C(=O)C(NCCCNC(=O)OC(C)(C)C)c1nc2cc(Cl)ccc2c(=O)[nH]1,,CN(C)C=O,,CCOC(C)=O,O,val
US06548494B1,Brc1ccncc1.O=Cc1ccc(-c2ccccn2)cc1>>O=Cc1ccc(-c2ccncc2)cc1,,CCN(CC)CC,,Cl,,val
US20090093524A1,COC(=O)c1ccc2cc(-c3ccc(OC)cc3)sc2c1>>COC(=O)c1ccc2cc(-c3ccc(O)cc3)sc2c1,,ClCCl,,BrB(Br)Br,,val
US04380638,COC1=NS(=O)N=C1N.N=C(N)Nc1cccc(OCCCN)c1>>N=C(N)Nc1cccc(OCCCNC2=NS(=O)N=C2N)c1,,CO,,,,val
US20120115899A1,NC1CCN(CCn2c(=O)ccc3ncc(F)cc32)CC1.O=Cc1cnc(CO)c(Br)c1>>O=c1ccc2ncc(F)cc2n1CCN1CCC(NCc2cnc(CO)c(Br)c2)CC1,,ClCCCl,,O=C([O-])O.[Na+],,val
US20070293670A1,Cc1nc(Cl)c2c(C)cn(-c3c(C)cc(Br)cc3C)c2n1.OCCC1=CCNCC1>>Cc1nc(N2CC=C(CCO)CC2)c2c(C)cn(-c3c(C)cc(Br)cc3C)c2n1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US20100137587A1,CCOC(=O)c1nc2ccccn2c1CCc1ccccc1>>O=C(O)c1nc2ccccn2c1CCc1ccccc1,,CCO,,[Na+].[OH-],,val
US20060135522A1,COC(=O)c1ccc2c(=O)c3cccc(OC)c3oc2c1>>COc1cccc2c(=O)c3ccc(C(=O)O)cc3oc12,,CO,,[Na+].[OH-],,val
US05792772,C1CCOC1.CC1(O)CCC2CC1(OB(O)CCCC[C@H](Cl)Br)C2(C)C.C[Mg]>>CC1(O)CCC2CC1(O)C2(C)C.C[C@H](CCCCBr)B([O-])[O-],,C1CCOC1,,[Cl-].[NH4+],,val
US20150210705A1,CC(C)N.Cc1ccc(S(=O)(=O)n2ccc3nc(Br)cnc32)cc1>>Cc1ccc(S(=O)(=O)n2ccc3nc(NC(C)C)cnc32)cc1,,C1COCCO1,,c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1,O=C([O-])[O-].[Cs+].[Cs+],val
US20110003787A1,COC[C@H](C)Oc1cc(Oc2ccc(C(C)=O)cc2)cc(-c2ccc(-c3nccs3)n2C(=O)OC(C)(C)C)c1>>COC[C@H](C)Oc1cc(Oc2ccc(C(C)=O)cc2)cc(-c2ccc(-c3nccs3)[nH]2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06313310B1,COC(=O)c1ccc(C(O)C#Cc2cccc3c2/C(=C/c2[nH]ccc2OC)C(=O)N3)cc1>>COc1cc[nH]c1/C=C1\C(=O)Nc2cccc(C#CC(O)c3ccc(C(=O)O)cc3)c21,,C1CCOC1,O,[Li]O,,val
US20120035159A1,C=CCN(C[C@@H](C)N(CC=C)S(=O)(=O)c1ccccc1[N+](=O)[O-])C(=O)OC(C)(C)C>>C[C@@H]1CN(C(=O)OC(C)(C)C)CC=CCN1S(=O)(=O)c1ccccc1[N+](=O)[O-],,ClCCl,,,,val
US07728155B2,Cc1ccc(S(=O)(=O)Cl)cc1.OCC(O)Cc1cc(Cl)c2ccccc2c1OCc1ccccc1>>Cc1ccc(S(=O)(=O)OCC(O)Cc2cc(Cl)c3ccccc3c2OCc2ccccc2)cc1,,c1ccncc1,,,,val
US05283327,C#CCCCCCCC.CC(=O)OC[C@H]1O[C@@H](n2cnc3c(Cl)nc(I)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O>>CCCCCCCC#Cc1nc(Cl)c2ncn([C@@H]3O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H]3OC(C)=O)c2n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,CCN(CC)CC,,val
US20110053909A1,CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cccc(CCOCCC(=O)O)c4F)CC3)C2)cs1.COC(CNC1CCCCCC1)OC>>COC(CN(C(=O)CCOCCc1cccc(CN2CCC3(CC2)CN(C(=O)c2csc(C(C)C)n2)CCO3)c1F)C1CCCCCC1)OC,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140315934A1,CCOC(=O)c1cc(O)n(Cc2ccccc2F)n1.CI>>CCOC(=O)c1cc(OC)n(Cc2ccccc2F)n1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100035865A1,CCO.O=C1CCCO1>>CCOC(=O)CCCO,,CCOCC,,C1CCOC1,Cl,val
US20130053366A1,CNC.Cc1ccc2c(c1)c1c(n2CC(OS(C)(=O)=O)c2cnccn2)CCN2CCCC12>>Cc1ccc2c(c1)c1c(n2CC(c2cnccn2)N(C)C)CCN2CCCC12,,O,,,,val
US20120142705A1,Cn1ccc(N)n1.O=C1C(=O)N(C(CC2CCCC2)C(=O)O)c2cccc(Cl)c21>>Cn1ccc(NC(=O)C(CC2CCCC2)N2C(=O)C(=O)c3c(Cl)cccc32)n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US04294845,C1COCCO1.CC(C)(C)C1(O)C=CC(Cl)=CC1C(O)c1ccccc1.O=C(O)C(Cl)Cl>>CC(C)(C)C1(c2ccccc2)OC(C(=O)O)Oc2ccc(Cl)cc21,,C1COCCO1,,O,[H-].[Na+],val
US20020137974A1,Brc1ccccc1.CC(C)(C)[PH](=O)C(C)(C)C>>CC(C)(C)P(=O)(c1ccccc1)C(C)(C)C,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20100021423A1,CCOCC.COc1c(CC(C)(C#N)c2ccc(NS(C)(=O)=O)cc2)cc(Br)cc1C(C)(C)C>>COc1c(CC(C)(C=O)c2ccc(NS(C)(=O)=O)cc2)cc(Br)cc1C(C)(C)C,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20110053972A1,COC(=O)c1cc(Br)n(C)c1.Cn1nccc1B1OC(C)(C)C(C)(C)O1>>COC(=O)c1cc(-c2ccnn2C)n(C)c1,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US04327102,Cl.ClCc1ccccn1.Fc1c(F)c(F)c(S)c(F)c1F>>Cl.Fc1c(F)c(F)c(SCc2ccccn2)c(F)c1F,,CCO,,[Na+].[OH-],,val
US06277847B1,CI.COC(=O)c1c(Cl)ccc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c1C>>COC(=O)c1c(Cl)ccc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c1C,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US04650810,CCOC(CCCN1C(=O)c2ccccc2C1=O)OCC.NNc1ccc(CC(N)=O)cc1>>NC(=O)Cc1ccc2[nH]cc(CCN3C(=O)c4ccccc4C3=O)c2c1,,CC(=O)O,,CCOC(C)=O,Cl,val
US20160237091A1,O=[N+]([O-])c1cc2c(cc1Br)c(I)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1>>Nc1cc2c(cc1Br)c(I)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1,[Fe],CC(=O)O,O,,,val
US20120283297A1,CCOC(=O)CCCn1ncc2cc(C#N)c(CC)cc21.NO>>CCOC(=O)CCCn1ncc2cc(C(=N)NO)c(CC)cc21,,CCO,,Cl,O=C([O-])O.[Na+],val
US06080754,CCCc1ccccn1.O=C(CBr)c1ccc(OCc2ccccc2)cc1>>CCCc1cccc[n+]1CC(=O)c1ccc(OCc2ccccc2)cc1.[Br-],,CC(C)=O,,,,val
US20140213578A1,NC1c2ccccc2CCc2ccccc21.O=C(Cl)CCl>>O=C(CCl)NC1c2ccccc2CCc2ccccc21,,Cc1ccccc1,,,,val
US20110152282A1,Brc1cccc2c1CCNC2.C=CS(C)(=O)=O>>CS(=O)(=O)CCN1CCc2c(Br)cccc2C1,,ClCCl,,,,val
US20020065271A1,CC(C)(C)OC(=O)[C@H](CNC(=O)c1ccc(CCC(=O)NC2=NCCCN2)cc1)NS(=O)(=O)c1cccc2cccnc12>>O=C(CCc1ccc(C(=O)NC[C@H](NS(=O)(=O)c2cccc3cccnc23)C(=O)O)cc1)NC1=NCCCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150307522A1,Cc1cc(O)ccc1-c1c(C)c(=O)n(COCc2ccccc2)c(=O)n1C.Clc1ncnc2ccsc12>>Cc1cc(Oc2ncnc3ccsc23)ccc1-c1c(C)c(=O)n(COCc2ccccc2)c(=O)n1C,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050182103A1,COC(=O)c1cnc(-c2ccc(Cl)cc2Cl)c(-c2ccc(Cl)cc2)c1>>O=C(O)c1cnc(-c2ccc(Cl)cc2Cl)c(-c2ccc(Cl)cc2)c1,,CO,,Cl,[Na+].[OH-],val
US05998452,CC(C)c1cc(C2SCC(=O)N2CCCO)cc(C(C)C)c1O.O=S(Cl)Cl>>CC(C)c1cc(C2SCC(=O)N2CCCCl)cc(C(C)C)c1O,,ClCCl,,,,val
US20040121965A1,CN.Cc1ccccc1C(C)(C)C=O.[C-]#N>>CNC(C#N)C(C)(C)c1ccccc1C,,CO,O,Cl,,val
US20130005707A1,CC(C)(C)[Si](C)(C)OCCN1Cc2cc([N+](=O)[O-])ccc2C1=O>>CC(C)(C)[Si](C)(C)OCCN1Cc2cc(N)ccc2C1=O,[Pd],CO,,[H][H],,val
US20090192150A1,CCO.CNC(=O)c1cnc(C)cc1Cl>>CCOc1cc(C)ncc1C(=O)NC,,O,,C,C[O-].[Na+],val
US20060135504A1,FC(F)(F)c1ccc(C(=C2CCNCC2)c2ccc(C(F)(F)F)cc2)cc1.O=[N+]([O-])c1ccc(CBr)cc1>>O=[N+]([O-])c1ccc(CN2CCC(=C(c3ccc(C(F)(F)F)cc3)c3ccc(C(F)(F)F)cc3)CC2)cc1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20020156081A1,NCCO.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCNCC1.O=C(Cl)CCl>>Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(C(=O)CNCCO)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04278677,C1=C(c2c[nH]c3ccccc23)CCNC1.CCCCCI>>CCCCCN1CC=C(c2c[nH]c3ccccc23)CC1,O=[Ag],CC(C)=O,,,,val
US05561101,CO.COc1cc(OC)nc(C2(C#N)OC(=O)c3c(Cl)cccc32)n1>>COc1cc(OC)nc(C2(OC)OC(=O)c3c(Cl)cccc32)n1,,CO,,C[O-].[Na+],,val
US04554276,O=C(O)CCCC=Cc1ccc(Cl)cc1>>O=C(O)CCCCCc1ccc(Cl)cc1,[Pd],CCOC(C)=O,,,,val
US20120172351A1,COC(=O)c1cccc(Nc2ccc(F)cc2NC(=O)[C@H]2CCCO2)c1C>>COC(=O)c1cccc(-n2c([C@H]3CCCO3)nc3cc(F)ccc32)c1C,,O,,,,val
US20150175550A1,COC(=O)c1nc(C)c2cccc(Oc3ccccc3)c2c1O.NCC(=O)O>>Cc1nc(C(=O)NCC(=O)O)c(O)c2c(Oc3ccccc3)cccc12,,CO,,C[O-].[Na+],,val
US20090069297A1,Brc1cnc2c(Oc3ccc(Nc4nnc(-c5ccccc5)c5ccccc45)cc3)ccnc2c1>>c1ccc(-c2nnc(Nc3ccc(Oc4ccnc5cccnc45)cc3)c3ccccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,C[O-].[Na+],,val
US20150210688A1,C/C=C/OCC.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCO/C=C(\C)C(=O)C(F)(F)F,,CCOCC,,c1ccncc1,,val
US20050267180A1,CCO[C@H](C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1)[C@H](O)c1ccc(OCc2ccccc2)cc1C.CO>>CCO[C@H](C(=O)OC)[C@H](O)c1ccc(OCc2ccccc2)cc1C,,CO,,C[O-].[Na+],,val
US06307056B1,O=C1Nc2cccc(I)c2/C1=C/c1ccc[nH]1.OB(O)c1cccc(Cl)c1>>O=C1Nc2cccc(-c3cccc(Cl)c3)c2/C1=C/c1ccc[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20040102436A1,CC(C)N(CCCCOCC(=O)O)c1cnc(-c2ccccc2)c(-c2ccccc2)n1.N>>CC(C)N(CCCCOCC(N)=O)c1cnc(-c2ccccc2)c(-c2ccccc2)n1,,C1CCOC1,,CCN(CC)CC,CCOC(=O)Cl,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n([C@@H]2C[C@H](OCC(C)(C)O)C2)c2nc(C)nn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2F)c(=O)n([C@@H]2C[C@H](OCC(C)(C)O)C2)c2nc(C)nn12,,CCOC(C)=O,CS(C)=O,[Cl-].[Na+],,val
US20120196864A1,CN1CCCC1CCN.COc1cc(C=O)c(Cl)cc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F.O=C1NC(=S)CS1>>COc1cc(/C=C2\SC(=O)N=C2NCCC2CCCN2C)c(Cl)cc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,,CCO,O,CC(C)(C)[O-].[K+],,val
US05686424,CC[C@H](C)[C@H](N)C(=O)NCc1ccccc1.O=C(CBr)c1ccc(-c2ccccc2)cc1.O=C(O)[C@@H]1CCCN1>>CC[C@H](C)[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)c1ccc(-c2ccccc2)cc1,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20140309208A1,COc1c(Nc2cccc(C(=O)N3CCOCC3)c2O)c(=O)c1=O.Cc1ccc(C(N)C2(C)COC2)o1>>Cc1ccc(C(Nc2c(Nc3cccc(C(=O)N4CCOCC4)c3O)c(=O)c2=O)C2(C)COC2)o1,,CO,,,,val
US20090270436A1,CN(C)C=O.O=C(O)c1cc(Cl)nc(OCc2ccccc2)c1>>COC(=O)c1cc(Cl)nc(OCc2ccccc2)c1,CN(C)C=O,ClC(Cl)Cl,,O=C(Cl)C(=O)Cl,,val
US05140031,FC(F)(F)c1ccc(N=C=S)cc1.N#CN>>N#CNC(=S)Nc1ccc(C(F)(F)F)cc1,,CCO,,[Na],,val
US05616599,CCCCc1nc(C#N)c(C#N)n1C(c1ccccc1)(c1ccccc1)c1ccccc1.CCOC(C)=O.CC[Mg]Br>>CCCCc1nc(C(=O)CC)c(C#N)n1C(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,CCOCC,[Cl-].[NH4+],,val
US20160051529A1,CC(=O)O.CCOC(=O)C(Cc1ccc(OCC(=NOC)c2cccc(OC)c2)cc1)OCC>>CCOC(Cc1ccc(OCC(=O)c2cccc(OC)c2)cc1)C(=O)O,,Cl,,,,val
US20130225524A1,COC(=O)c1cc(N)ccc1Br.OB(O)c1ccoc1>>COC(=O)c1cc(N)ccc1-c1ccoc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US04590201,Cc1cc(Cl)c(C(=O)Cl)c(Cl)c1.c1ccccc1>>Cc1cc(Cl)c(C(=O)c2ccccc2)c(Cl)c1,,c1ccccc1,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20110313002A1,CC(C)C[C@@H](C(=O)O)N1CC2=C(Oc3c(Cl)cccc3C2)C1=O.Nc1ccccn1>>CC(C)C[C@@H](C(=O)Nc1ccccn1)N1CC2=C(Oc3c(Cl)cccc3C2)C1=O,,ClCCl,O,On1nnc2ccccc21,,val
US20160060273A1,CC(C)(C)OC(=O)N1CC2(CC(Br)=NO2)C1.CCOC(=O)C1(C)CCNCC1>>CCOC(=O)C1(C)CCN(C2=NOC3(C2)CN(C(=O)OC(C)(C)C)C3)CC1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20160009683A1,CCOC(=O)C(F)(F)I.COc1ccc(I)c(C(F)(F)F)c1>>CCOC(=O)C(F)(F)c1ccc(OC)cc1C(F)(F)F,[Cu],CS(C)=O,,[Cl-].[NH4+],,val
US20080139631A1,CCCc1cc2c(C(F)(F)F)c(C#N)ccc2n1CC(=N)NO.O=C(Cl)c1cccnc1Cl>>CCCc1cc2c(C(F)(F)F)c(C#N)ccc2n1Cc1noc(-c2cccnc2Cl)n1,,CC#N,,CCN(CC)CC,,val
US20150018377A1,Cc1cccc(C)c1Oc1ccc(NC(=O)C(C)(C)NC(=O)OC(C)(C)C)cn1>>Cc1cccc(C)c1Oc1ccc(NC(=O)C(C)(C)N)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060097226A1,CCCC1CCC(C=Cc2c(C)cc(OCC)c(F)c2F)CC1>>CCCC1CCC(CCc2c(C)cc(OCC)c(F)c2F)CC1,[Pd],Cc1ccccc1,,[H][H],,val
US20060142312A1,CSc1ncc2cc(Cc3nnc(C)o3)c(=O)n(C3CCCC3)c2n1.O=S(=O)(c1ccccc1)N1OC1c1ccccc1>>Cc1nnc(Cc2cc3cnc(S(C)=O)nc3n(C3CCCC3)c2=O)o1,,ClCCl,,,,val
US20100210620A1,CC(C)(N)CO.O=C(O)c1ccc(OC(F)(F)F)cc1>>CC(C)(CO)NC(=O)c1ccc(OC(F)(F)F)cc1,,CCOCC,ClCCl,O=S(Cl)Cl,,val
US20070244132A1,O=C(OC(=O)c1ccccc1)c1ccccc1.OCCOCCO>>O=C(OCCOCCO)c1ccccc1,,c1ccncc1,,,,val
US04447446,CCOC(C#N)NC(=O)c1cccc(Cl)c1.S>>CCOC(NC(=O)c1cccc(Cl)c1)C(N)=S,,Cc1ccccc1,,CCN(CC)CC,,val
US08008296B2,C1CCNCC1.O=C(O)c1ccc(S(=O)(=O)Cl)cc1>>O=C(O)c1ccc(S(=O)(=O)N2CCCCC2)cc1,,ClCCl,,CCN(CC)CC,,val
US20070208078A1,CC(C)=CCCC(C)CC(O)c1c(O)c(Cl)c(C)c(C=O)c1O>>Cc1c(Cl)c(O)c(C(O)CC(C)CCCC(C)C)c(O)c1C=O,[Pd],CCO,,[H][H],,val
US20110263556A1,COc1ccc([N+](=O)[O-])cc1C(=O)Nc1ccc(Br)cc1>>COc1ccc(N)cc1C(=O)Nc1ccc(Br)cc1,[Ni],C1CCOC1,,,,val
US20030171579A1,CCCN.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCCNC(=O)C(F)(F)F,,C1CCOC1,,CCN(CC)CC,,val
US06355631B1,COC(=O)Cl.Fc1cc(F)cc(CNC2CN(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)C2)c1>>COC(=O)N(Cc1cc(F)cc(F)c1)C1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1,,C1CCOC1,,O,[H-].[Na+],val
US20120302540A1,CN1CC(c2ccccc2)C2(CCCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)OC(C)(C)C)C2)C1=O>>CN1CC(c2ccccc2)C2(CCCN(C(=O)[C@H](N)COCc3ccccc3)C2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US03943124,C[C@]12CCC(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C(N)=O)CC[C@@H]12>>C[C@]12CCC(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C#N)CC[C@@H]12,,ClC(Cl)Cl,,,,val
US20140123549A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.OC(c1ccccc1)(c1ccccc1)c1ccccc1.Oc1cccc(O)c1>>Oc1cc(O)c(C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1C(c1ccccc1)(c1ccccc1)c1ccccc1,,CC(=O)O,,,,val
US05063197,ClCCc1ccccc1.O=Cc1ccc(O)cc1>>O=Cc1ccc(OCCc2ccccc2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20040006226A1,Cc1onc(-c2ccccc2)c1C(=O)C1=C(N2CCCC2)c2ccccc2C1.NN>>Cc1onc(-c2ccccc2)c1-c1[nH]nc2c1Cc1ccccc1-2,,CCO,,Cl,O,val
US20100029589A1,CC(C)(C)OC(=O)N1[C@@H](CCO)COC1(C)C.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1[C@@H](CCOS(C)(=O)=O)COC1(C)C,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20070219198A1,CS(=O)(=O)c1cc(F)ccc1N1CCNCC1.O=S(=O)(Cl)c1ccc2ccccc2c1>>CS(=O)(=O)c1cc(F)ccc1N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070078184A1,COC(=O)Cc1ccc(-c2c(C)cc(OCCOC(C)=O)cc2C)cc1>>Cc1cc(OCCO)cc(C)c1-c1ccc(CC(=O)O)cc1,,CCO,,Cl,[Na+].[OH-],val
US20030232992A1,COc1sc(-c2ccc(C(=O)N3CCN(CCCN4CCN(C(=O)c5ccc(-c6sc(OC)c(C)c6OC)cc5)CC4)CC3)cc2)c(OC)c1C.Cl.ClC(Cl)Cl>>COc1sc(-c2ccc(C(=O)N3CCN(CCCN4CCN(C(=O)c5ccc(-c6sc(OC)c(C)c6OC)cc5)CC4)CC3)cc2)c(OC)c1C.Cl.Cl,,ClC(Cl)Cl,,CCOC(C)=O,,val
US04690931,COc1c(C)cc(C(=O)C(C)Br)cc1C.Cc1ccc(CC2CCNCC2)cc1>>COc1c(C)cc(C(=O)C(C)N2CCC(Cc3ccc(C)cc3)CC2)cc1C,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20100035883A1,CCOC(=O)c1cc(F)cc2c1C(=O)C(c1ncnn1C)C(c1ccccc1)N2.NN>>Cn1ncnc1C1c2n[nH]c(=O)c3cc(F)cc(c23)NC1c1ccccc1,,CO,,O,,val
US20050107347A1,COC(=O)C(O)Cc1cc(Br)c(Oc2cc(/C=C/c3ccccc3)c(O)c(C(C)C)c2)c(Br)c1>>CC(C)c1cc(Oc2c(Br)cc(CC(O)C(=O)O)cc2Br)cc(/C=C/c2ccccc2)c1O,,C1CCOC1,,[Li+].[OH-],,val
US20130012499A1,C1CC(N2CCOCC2)CCN1.COC(=O)c1c(CBr)c(-c2cccc(C(F)(F)F)c2)nc2cc(OC(C)C)c(S(C)(=O)=O)cc12>>COC(=O)c1c(CN2CCC(N3CCOCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2cc(OC(C)C)c(S(C)(=O)=O)cc12,,CC#N,,,,val
US20070197622A1,OC(c1cc(F)cc(F)c1)(c1cc(F)cc(F)c1)c1c[nH]cn1>>Fc1cc(F)cc(C(c2cc(F)cc(F)c2)c2c[nH]cn2)c1,[Pd],CCO,,Cl,,val
US20040006076A1,CN.Cc1nc(Cl)sc1S(N)(=O)=O>>CNc1nc(C)c(S(N)(=O)=O)s1,,CC#N,,,,val
US05922871,CC(C)Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)N3CCNCC3)cc2)CC1.OCCCBr>>CC(C)Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)N3CCN(CCCO)CC3)cc2)CC1,,CCO,,CCN(CC)CC,,val
US20120289522A1,CI.Cc1noc(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)c1CCC(=O)Nc1ccccc1>>Cc1noc(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)c1CCC(=O)N(C)c1ccccc1,,C1CCOC1,,,,val
US05233046,C(=Nc1ccccc1)c1ccccc1.c1ccc(Cn2cnc3ccccc32)cc1>>C(#Cc1ccccc1)c1ccccc1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20090018122A1,CC(C)CNc1c([N+](=O)[O-])c2nnnn2c2ccc(OCc3ccccc3)cc12>>CC(C)CNc1c(N)c2nnnn2c2ccc(OCc3ccccc3)cc12,[Pt],CC#N,,[H][H],,val
US20080125411A1,ClCCCl.O=S(Cl)Cl.OCCN1CCNCC1>>Cl.Cl.ClCCN1CCNCC1,,ClCCCl,,,,val
US20160083379A1,CC(C)(C)[Si](C)(C)Oc1ccc2c(c1)CCCN2c1ccccc1>>Oc1ccc2c(c1)CCCN2c1ccccc1,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20070185165A1,NCCCc1nonc1-c1noc(=O)n1-c1ccc(F)c(Cl)c1.NS(N)(=O)=O>>NS(=O)(=O)NCCCc1nonc1C(=NO)Nc1ccc(F)c(Cl)c1,,O,c1ccncc1,O=C(O)C(F)(F)F,[Na+].[OH-],val
US04483987,CCOCCc1c(-c2ccccc2)nc(N)n2ncnc12.CI>>CCOCCc1c(-c2ccccc2)nc(NC)n2ncnc12,,CC(C)(C)O,,O,CC(C)(C)[O-].[K+],val
US04212867,CCOC(=O)C(=O)Cl.CCOc1ccc(C(=O)NN)cc1>>CCOC(=O)C(=O)NNC(=O)c1ccc(OCC)cc1,,C1COCCO1,,CCN(CC)CC,,val
US20150299179A1,CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@@H]4NCCO[Si](C)(C)C(C)(C)C)ns2)cc1C#N.Cl>>CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@@H]4NCCO)ns2)cc1C#N.Cl,,C1COCCO1,CCOCC,,,val
US20090264445A1,CCOC(=O)C=C(C)Cl.Cc1ccc(O)cn1>>CCOC(=O)/C=C(\C)Oc1ccc(C)nc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20120115841A1,CS(=O)(=O)Cl.OCc1cc(F)c(Br)c(F)c1>>CS(=O)(=O)OCc1cc(F)c(Br)c(F)c1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,N#N,val
US20110224191A1,CC(c1c(Cl)ccc(F)c1Cl)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12.NS(N)(=O)=O>>CC(c1c(Cl)ccc(F)c1Cl)c1c[nH]c2ncc(-c3cnn(C4CCN(S(N)(=O)=O)CC4)c3)cc12,,C1COCCO1,,,,val
US20150031708A1,COc1ncc(-c2nc(N)ccc2C)cc1C.O=C(O)C1(c2ccc3c(c2)COC3)CC1>>COc1ncc(-c2nc(NC(=O)C3(c4ccc5c(c4)COC5)CC3)ccc2C)cc1C,CN(C)C=O,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20110046395A1,CCOC(=O)CCc1ccc(/C(Nc2ccc(CN(C)C)cc2)=C2/C(=O)Nc3cc(F)ccc32)cc1>>CN(C)Cc1ccc(N/C(=C2\C(=O)Nc3cc(F)ccc32)c2ccc(CCC(=O)O)cc2)cc1,,CO,,Cl,[Na+].[OH-],val
US20090105305A1,COCc1ccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)cc1[N+](=O)[O-]>>COCc1ccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)cc1N,,C1CCOC1,CO,,,val
US07829584B2,CC(C)(C)OC(=O)Nc1noc2cc(CNC(=O)Cc3c(C#N)ccc(Cl)[n+]3[O-])ccc12.NCC(F)(F)c1ccccn1>>CC(C)(C)OC(=O)Nc1noc2cc(CNC(=O)Cc3c(C#N)ccc(NCC(F)(F)c4ccccn4)[n+]3[O-])ccc12,,CS(C)=O,,ClCCl,O,val
US04161529,C=CCBr.c1ccc(Oc2ccc(C3CCCN3)cc2)cc1>>C=CCN1CCCC1c1ccc(Oc2ccccc2)cc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20080293775A1,CS(=O)(=O)c1ccc(Oc2cc(C(F)(F)F)ccc2O)c(Cl)c1.N#CCBr>>CS(=O)(=O)c1ccc(Oc2cc(C(F)(F)F)ccc2OCC#N)c(Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060223829A1,COC(=O)c1ccccc1C1CCN(S(=O)(=O)c2cccc3ccccc23)CC1>>O=S(=O)(c1cccc2ccccc12)N1CCC(c2ccccc2CO)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090203676A1,C1CNCCN1.CS(=O)c1ccc(F)cc1>>CS(=O)c1ccc(N2CCNCC2)cc1,,O,,,,val
US20030130389A1,CO[Si](OC)(OC)[c-]1cccc1.CO[Si](OC)(OC)[c-]1cccc1.[Fe+2]>>O[Si](O)(O)[c-]1cccc1.O[Si](O)(O)[c-]1cccc1.[Fe+2],,CCOCC,,CC(=O)O,,val
US20140024649A1,COC(=O)c1ccc(-c2nc(CS(=O)(=O)c3ccc(C(F)(F)F)cc3)c(C)o2)cc1>>Cc1oc(-c2ccc(C(=O)O)cc2)nc1CS(=O)(=O)c1ccc(C(F)(F)F)cc1,,Cl,,,,val
US20150072969A1,CCOC(=O)CC1(c2ccc(OCc3cccc(Br)c3)cc2)COC1.OB(O)c1ccc(O)nc1>>CCOC(=O)CC1(c2ccc(OCc3cccc(-c4ccc(O)nc4)c3)cc2)COC1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20050107364A1,CSC(SC)=C1C(=O)c2ccccc2C(C)(C)C1=O.Nc1ccccc1S(N)(=O)=O>>CC1(C)C(=O)C(C2=NS(=O)(=O)c3ccccc3N2)=C(O)c2ccccc21,,Cc1ccccc1,,,,val
US20090044345A1,CN(C)c1ccnc(-c2cc(N(C)C)cc(CO)n2)c1.O=S(Cl)Cl>>CN(C)c1ccnc(-c2cc(N(C)C)cc(CCl)n2)c1,,ClCCl,,,,val
US20050059673A1,COc1ccc2occ(CC(C)=O)c2c1.Cc1cc(N2CCNCC2)c2ncccc2c1>>COc1ccc2occ(CC(C)N3CCN(c4cc(C)cc5cccnc45)CC3)c2c1,,CC(=O)O,ClCCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04593035,CCOC(=O)Cl.Nc1ccc2c(c1)CCC(=O)N2>>CCOC(=O)Nc1ccc2c(c1)CCC(=O)N2,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US04031101,C[C@H]1CCC[C@@H](C)N1.OCCCBr>>C[C@H]1CCC[C@@H](C)N1CCCO,,Cc1ccccc1C,,,,val
US20110112080A1,C=Cc1nc(OC)cc(C(=O)OC)n1>>CCc1nc(OC)cc(C(=O)OC)n1,[Pd],CO,,,,val
US20080058309A1,CC(Cl)C(=O)Nc1c(Cl)ccc2nc(N3CC[C@@H](O[Si](C)(C)C(C)(C)C)C3)ccc12.Nc1ccc(F)c(F)c1>>CC(Nc1ccc(F)c(F)c1)C(=O)Nc1c(Cl)ccc2nc(N3CC[C@@H](O)C3)ccc12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040224959A1,CCOC(=O)c1cccc(N)c1.ClCCNCCCl>>CCOC(=O)c1cccc(N2CCNCC2)c1,,Cc1ccccc1C,,Cl,,val
US20040214817A1,C1COCCN1.Nc1nc(Nc2ccc3c(c2)OCO3)nn1-c1ccc(C(=O)O)cc1>>Nc1nc(Nc2ccc3c(c2)OCO3)nn1-c1ccc(C(=O)N2CCOCC2)cc1,,C1CCOC1,O,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20080045536A1,COc1ccc(CN(c2ccccc2)c2cc(Cl)nn3c(C(=O)O)cnc23)cc1.Nc1ccncc1>>COc1ccc(CN(c2ccccc2)c2cc(Cl)nn3c(C(=O)Nc4ccncc4)cnc23)cc1,,CC#N,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20100331293A1,O=[N+]([O-])c1cc(N2CCOCC2)ccc1N1CCOCC1>>Nc1cc(N2CCOCC2)ccc1N1CCOCC1,,CCOC(C)=O,,,,val
US20050038035A1,CC1CN(c2ccc(NC(=O)C3=C(c4ccc(C(F)(F)F)cc4)CCCC3)cc2)CCN1.N#Cc1cccc(C=O)c1>>CC1CN(c2ccc(NC(=O)C3=C(c4ccc(C(F)(F)F)cc4)CCCC3)cc2)CCN1Cc1cccc(C#N)c1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04474754,C1COCCO1.CC(C)CCO[N+](=O)[O-].C[C@@H](O)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NN>>CCOC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO,,CN(C)C=O,,CCN(CC)CC,Cl,val
US04992547,CC(C)(Br)C(=O)c1ccc(N2CCCCC2)cc1.CO>>COC1(c2ccc(N3CCCCC3)cc2)OC1(C)C,,CO,,C[O-].[Na+],,val
US20030092676A1,CS(=O)(=O)OCCc1cccc2cc[nH]c12.NCCO>>OCCNCCc1cccc2cc[nH]c12,,CCO,CCOC(C)=O,,,val
US20070275962A1,N#Cc1c(NC(=O)C2CC2)oc2c1CCOC2.O>>NC(=O)c1c(NC(=O)C2CC2)oc2c1CCOC2,,O,,[Na+].[OH-],,val
US04055592,CS(N)(=O)=O.O=C(Cl)C(Oc1cccc(C(F)(F)F)c1)c1ccc(Cl)cc1>>CS(=O)(=O)NC(=O)C(Oc1cccc(C(F)(F)F)c1)c1ccc(Cl)cc1,,C1CCOC1,,[Na],,val
US20040254205A1,COc1cc2ncnc(Nc3cccc(Br)c3)c2c(N)c1OC.S=C(n1ccnc1)n1ccnc1>>COc1cc2ncnc3c2c(c1OC)NC(=S)N3c1cccc(Br)c1,,ClCCCl,,,,val
US20120040949A1,CN1CCNCC1.O=[N+]([O-])c1nccnc1Br>>CN1CCN(c2cnc([N+](=O)[O-])cn2)CC1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20130053397A1,C/C(O)=C/C(=O)c1ccncc1.N#CCC(N)=O>>Cc1cc(-c2ccncc2)[nH]c(=O)c1C#N,,CCO,,C1CCNCC1,,val
US20120010228A1,CC(C)(C)OC(=O)c1ccccc1CN1CN(c2ccccc2)C2(CCN(CCCN3C(=O)C4(CC4)c4ccccc43)CC2)C1=O>>O=C(O)c1ccccc1CN1CN(c2ccccc2)C2(CCN(CCCN3C(=O)C4(CC4)c4ccccc43)CC2)C1=O,,O=CO,,CC[SiH](CC)CC,,val
US20150111877A1,COC(=O)c1cnc2c(c1)NC(=O)[C@H](NC(=O)OC(C)(C)C)C2>>CC(C)(C)OC(=O)N[C@@H]1Cc2ncc(C(=O)O)cc2NC1=O,,C1CCOC1,CO,[Na+].[OH-],,val
US20080058515A1,COc1cc([N+](=O)[O-])ccc1OCCN(C(C)C)C(C)C>>COc1cc(N)ccc1OCCN(C(C)C)C(C)C,[Pd],CCO,O,[H][H],,val
US20010039348A1,COC(=O)c1snnc1C>>Cc1nnsc1C(=O)O,,CO,,Cl,[Na+].[OH-],val
US20090181319A1,C1CCSC1.O=C(CBr)c1ccc2ccccc2c1>>O=C(C[S+]1CCCC1)c1ccc2ccccc2c1.[Br-],,CC(C)=O,O,,,val
US20040023989A1,NC(=O)c1n[nH]c(C2CCCC2)c1[N+](=O)[O-]>>NC(=O)c1n[nH]c(C2CCCC2)c1N,[Pd],CCO,,,,val
US06350878B1,CS(=O)(=O)Cl.C[C@@H](CCCO)CO[Si](C)(C)C(C)(C)C>>C[C@@H](CCCOS(C)(=O)=O)CO[Si](C)(C)C(C)(C)C,,CCOCC,ClCCl,CCN(CC)CC,,val
US04523030,COC(=O)C1=Cc2cc(C(=O)c3cccc(Cl)c3)c(O)cc21>>O=C(O)C1=Cc2cc(C(=O)c3cccc(Cl)c3)c(O)cc21,,CCOCC,,[Na+].[OH-],,val
US20050187390A1,COc1cccc(O)c1C(C)=O.O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4cc(Br)ccc4O)ccc3c1)n2C1CCCCC1>>COc1cccc(O)c1-c1ccc2cc(-c3nc4cc(C(=O)O)ccc4n3C3CCCCC3)ccc2n1,,CCO,,[K+].[OH-],,val
US05686424,N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1.O=C(O)[C@@H]1CCCN1CC(=O)C12CC3CC(CC(C3)C1)C2>>N[C@@H](Cc1ccccc1)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)C12CC3CC(CC(C3)C1)C2,,ClCCl,,CCN(CC)CC,,val
US20020177594A1,NO.O=Cc1ccc(-c2ccccc2)cc1>>ON=Cc1ccc(-c2ccccc2)cc1,,C1CCOC1,CCO,Cl,c1ccncc1,val
US20020147203A1,CNCCCN(C)C.ClCc1ccnc(Nc2ncc(-c3ccccc3)s2)c1>>CN(C)CCCN(C)Cc1ccnc(Nc2ncc(-c3ccccc3)s2)c1,,CS(C)=O,,O=C([O-])O.[Na+],,val
US20140088101A1,CCCN.COC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O>>CCCNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O,,CCO,,CC(=O)O,O,val
US20030092712A1,O=C(CCc1c(Br)cc(Br)nc1-c1ccc(F)cc1Cl)Nc1c(Cl)cccc1Cl>>O=C1CCc2c(cc(Br)nc2-c2ccc(F)cc2Cl)N1c1c(Cl)cccc1Cl,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110039829A1,CC(C)(C)C(=O)COc1cc(C(=O)O)nn1-c1ccccc1.CCOC(=O)N1CCN(C(=O)[C@@H](N)CNC(=O)OC(C)(C)C)CC1>>CCOC(=O)N1CCN(C(=O)[C@H](CNC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)C(C)(C)C)n(-c3ccccc3)n2)CC1,,CN(C)C=O,O,ClCCCl,On1nnc2ccccc21,val
US20030162787A1,CC(C)(C)OC(=O)N1CCCC1C(=O)O.Cc1cc(Br)ccc1N>>Cc1cc(Br)ccc1NC(=O)C1CCCN1C(=O)OC(C)(C)C,,CCOCC,ClCCl,O=C(Cl)C(=O)Cl,c1ccncc1,val
US07067537B2,CC(=O)OC(C)=O.N#Cc1cccc(N)c1>>CC(=O)Nc1cccc(C#N)c1,,c1ccncc1,,,,val
US05064825,CCCCc1nc(N(C)C(C)=O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1>>CCCCc1nc(NC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20120101100A1,CCNC(=O)Nc1cc(-c2nc3ccccc3s2)ccn1.O=C1CCC(=O)N1Br>>CCNC(=O)Nc1cc(-c2nc3ccccc3s2)c(Br)cn1,,CN(C)C=O,,,,val
US20090156603A1,CC(C)(C)OC(=O)N1CCN(CC(=O)CCl)C(=O)C1.NC(=S)Nc1ncc(Br)cc1Oc1ccc(F)cc1>>CC(C)(C)OC(=O)N1CCN(Cc2csc(Nc3ncc(Br)cc3Oc3ccc(F)cc3)n2)C(=O)C1,,CCO,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20130274260A1,O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(CCl)cc1.OB(O)c1cccc(Cl)c1>>O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(Cc2cccc(Cl)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,[I-].[Na+],,val
US20020183516A1,C=C(Br)CCCCCC.C=CCC(O)c1ccccc1.C[Si](C)(Cl)Cl.[Li]C(C)(C)C>>C=CCC(O[Si](C)(C)CC=CCCCCC)c1ccccc1,CN(C)c1ccncc1,CCOCC,,CCN(CC)CC,,val
US04855314,BrC(Br)(Br)Br.COc1ccc(CC(=O)NCCc2ccc3[nH]cc(CCO)c3c2)cc1>>COc1ccc(CC(=O)NCCc2ccc3[nH]cc(CCBr)c3c2)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090181942A1,CCOC(=O)c1cnn(CC[C@@H]2O[C@@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3ccnc32)c1>>COc1cccc([C@@H]2O[C@@H](CCn3cc(C(=O)O)cn3)c3nccn3-c3ccc(Cl)cc32)c1OC,,CO,,Cl,[Na+].[OH-],val
US20160024049A1,Cn1cc(C=O)cn1.c1cnc(-c2ccncc2)c(OC2CCNCC2)c1>>Cn1cc(CN2CCC(Oc3cccnc3-c3ccncc3)CC2)cn1,,CC#N,CC(=O)O,[Na+].[OH-],,val
US20140045855A1,C=CCNc1cccnc1Br.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=CCN(C(=O)OC(C)(C)C)c1cccnc1Br,,ClCCl,,,,val
US20110136787A1,C=CC(C)=O.COc1ccccc1CC(=O)c1ccccc1>>COc1ccccc1C1CCC(=O)C=C1c1ccccc1,,C1CCOC1,CCO,[K+].[OH-],,val
US04452851,COC(=O)CON=C(C(=O)CCl)C(=O)NC1C(=O)N2C(C(O)=S)=C(C)CS[C@H]12.NC(N)=S>>COC(=O)CON=C(C(=O)NC1C(=O)N2C(C(O)=S)=C(C)CS[C@H]12)c1csc(N)n1,,C1CCOC1,O,CC(=O)[O-].[Na+],,val
US20150189880A1,CCS(=O)(=O)c1cccnc1C(=O)Nc1ccc(OC(F)(F)F)cc1.CI>>CCS(=O)(=O)c1cccnc1C(=O)N(C)c1ccc(OC(F)(F)F)cc1,,CN(C)C=O,O,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20050085483A1,C=CCN.COC(=O)C(C)(C=O)NC(=O)OCc1ccccc1>>C=CCNCC(C)(NC(=O)OCc1ccccc1)C(=O)OC,,ClCCl,,O=S(=O)([O-])[O-].[Mg+2],,val
US20090149448A1,CC[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)OC(C)(C)C)CCN1C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CC[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)OC(C)(C)C)CCN1.O=C(O)C(F)(F)F,,ClCCl,,Cc1ccccc1,,val
US05428038,COc1cc2oc(=O)ccc2cc1OCC1CO1.Clc1cccc(N2CCNCC2)c1>>COc1cc2oc(=O)ccc2cc1OCC(O)CN1CCN(c2cccc(Cl)c2)CC1,,CC(C)O,,Cl,,val
US20070213341A1,C=C(N=Cc1cc(F)ccc1C)O[Si](C)(C)C.O=C1Nc2ccc(F)cc2/C1=C/c1cccc(Cl)c1>>Cc1ccc(F)cc1C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1ccc(F)cc12,,Cc1ccccc1,,,,val
US20030129590A1,Brc1ccccc1.O=Cc1ccccc1>>OC(c1ccccc1)c1ccccc1,II,CCOCC,CCOCC,[Mg],,val
US20120046472A1,CCCCCCOc1cc(-c2nnc(-c3cccc(Oc4ccc([N+](=O)[O-])cc4)c3)o2)c(OCCCCCC)cc1-c1nnc(-c2cccc(Oc3ccc([N+](=O)[O-])cc3)c2)o1>>O=[N+]([O-])c1ccc(Oc2cccc(-c3nnc(-c4cc(O)c(-c5nnc(-c6cccc(Oc7ccc([N+](=O)[O-])cc7)c6)o5)cc4O)o3)c2)cc1,,ClCCl,,BrB(Br)Br,,val
US20100286152A1,O=C(NNc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1cccnc1)N1CCN2CCC[C@@H]2C1>>O=C(NNc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](c1cccnc1)N1CCN2CCC[C@@H]2C1,,CCO,,,,val
US20160046635A1,CCCNc1nc(NC)c2nc(C#N)nc(NC)c2n1.O>>CCCNc1nc(NC)c2nc(C(N)=O)nc(NC)c2n1,,C1COCCO1,,[Na+].[OH-],,val
US20120010190A1,Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)O)cc1.NC[C@@H](O)CO>>Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)NC[C@@H](O)CO)cc1,,C1CCOC1,,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,,val
US20120157487A1,CC(C)(C)OC(=O)Nc1cc(CSc2ccc(Cl)cc2N)ccn1.O=S(=O)(Cl)c1cc2ccccc2o1>>CC(C)(C)OC(=O)Nc1cc(CSc2ccc(Cl)cc2NS(=O)(=O)c2cc3ccccc3o2)ccn1,,c1ccncc1,,,,val
US20020068735A1,CC1(C)OC(=O)Nc2ccc(-c3ccc(C#N)[nH]3)cc21.CI>>Cn1c(C#N)ccc1-c1ccc2c(c1)C(C)(C)OC(=O)N2,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060122184A1,COC(=O)c1ccc(-c2ccc(C(=O)N[C@@H](CC(C)C)C(=O)NCC#N)cc2)c(Cl)c1>>CC(C)C[C@H](NC(=O)c1ccc(-c2ccc(C(=O)O)cc2Cl)cc1)C(=O)NCC#N,,CCOC(C)=O,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04666925,CC(C)[Mg]Cl.O=C1CCc2cc(Cl)ccc21>>CC(C)C1=CCc2cc(Cl)ccc21,,C1CCOC1,,O,,val
US20120022226A1,O=C(Cl)CCCl.c1ccc2c(c1)CCC2>>O=C1CCc2cc3c(cc21)CCC3,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20090054493A1,CCOC(=O)COc1ccc(SC(CCc2ccccc2)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C>>Cc1cc(SC(CCc2ccccc2)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1OCC(=O)O,,CCO,,Cl,[Na+].[OH-],val
US04172130,CC(C)(C)OC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)O.O=C1CCC(=O)N1O>>CC(C)(C)OC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)ON1C(=O)CCC1=O,,C1COCCO1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05597848,COC(=O)CCCCc1ccccc1.O=C(Cl)Cc1ccccc1>>COC(=O)CCCCc1ccc(C(=O)Cc2ccccc2)cc1,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20150141419A1,CCCc1cccs1.ClC(Cl)OC(Cl)Cl>>CCCc1ccc(C=O)s1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US04558046,COC(=O)c1cn2c(=O)cc(C)nc2s1.O=S(=O)(Cl)Cl>>COC(=O)c1cn2c(=O)c(Cl)c(C)nc2s1,,CC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(C(=O)C2C(=O)OC(C)(C)OC2=O)CC1.COc1ccccc1-c1cccc2[nH]nc(N)c12>>COc1ccccc1-c1cccc2nn3c(C4CCN(C(=O)OC(C)(C)C)CC4)cc(=O)[nH]c3c12,,CC#N,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US05167949,CCOC(=N)COc1cccc(Cl)c1Cl.Cl.N>>Cl.N=C(N)COc1cccc(Cl)c1Cl,,CCO,,,,val
US20100105655A1,COC(=O)CC(=O)OC.COc1cc(F)ccc1[N+](=O)[O-]>>COC(=O)C(C(=O)OC)c1ccc([N+](=O)[O-])c(OC)c1,,CN(C)C=O,,[H-].[Na+],,val
US04435322,CCOC(=O)C(C(=O)OCC)N(Cc1ccccc1)Cc1ccc(OC)cc1OC>>CCOC(=O)C(NCc1ccc(OC)cc1OC)C(=O)OCC,[Pd],CCO,,,,val
US20040087600A1,O=S1(=O)CCOc2ccccc21.O=[N+]([O-])O>>O=[N+]([O-])c1ccc2c(c1)S(=O)(=O)CCO2,,O,,O=S(=O)(O)O,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c2)=C(C)C1=O,,CO,O,O=C([O-])O.[Na+],,val
US06372736B1,CC#N.ClCc1nc[nH]n1.O=C(N[C@H]1CCNC1)[C@@H]1CCCCN1c1nc2ccccc2o1>>N.O=C(N[C@H]1CCN(Cc2nc[nH]n2)C1)[C@@H]1CCCCN1c1nc2ccccc2o1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20120015972A1,COCOc1cc(I)ccc1C(=O)OC.Fc1cn2ccccc2c1Br>>COCOc1cc(-c2c(F)c(Br)c3ccccn23)ccc1C(=O)OC,,CN1CCCC1=O,,O,CC(=O)[O-].[K+],val
US20150023913A1,CC(C)[C@H](NC(=O)OC(C)(C)C)c1ncc[nH]1.CI>>CC(C)[C@H](NC(=O)OC(C)(C)C)c1nccn1C,,C1CCOC1,,[H-].[Na+],,val
US05474998,C=CC(=C)CBr.O=Cc1ccc(Cl)cc1O>>C=CC(=C)COc1cc(Cl)ccc1C=O,,ClCCl,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160250216A1,Fc1cc(Br)cc(C2=CC(c3cccc(Br)c3)n3nnnc3N2)c1>>Fc1cc(Br)cc(C2CC(c3cccc(Br)c3)n3nnnc3N2)c1,,CO,O,[BH4-].[Na+],,val
US05711939,CC(C)CCCCC(=O)O.CO>>COC(=O)CCCCC(C)C,,Cc1ccccc1,,O=S(=O)(O)O,,val
US05972965,O=C(Cl)OCc1ccccc1.O=C1CC[C@H](c2nc(-c3ccccc3)c(-c3ccccc3)o2)N1>>O=C(N[C@H](CCCO)c1nc(-c2ccccc2)c(-c2ccccc2)o1)OCc1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20090186879A1,COC(=O)c1ccc(Cl)c(N)c1NCCCO.COc1nc(C)nc(OC)c1N=C=S>>COC(=O)c1ccc(Cl)c(NC(=S)Nc2c(OC)nc(C)nc2OC)c1NCCCO,,C1CCOC1,,,,val
US06225324B1,N#Cc1cccc(N2CCC(O)C2)c1>>N#Cc1cccc(N2CCC(=O)C2)c1,,CS(C)=O,,CCN(CC)CC,O,val
US20080167345A1,Fc1ccc(Br)cc1.NC(=O)c1cc(F)cc2cn[nH]c12>>NC(=O)c1cc(F)cc2cn(-c3ccc(Br)cc3)nc12,,CCOC(C)=O,,CN(C)C=O,,val
US20090221655A1,Cc1noc2cc(N)ccc12.O=C(Cl)OCc1ccccc1>>Cc1noc2cc(NC(=O)OCc3ccccc3)ccc12,,CCOC(C)=O,O,C1CCOC1,O=C([O-])O.[Na+],val
US20150239921A1,CC(=O)c1cn(CC(=O)N2[C@@H]3CCC[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(P(=O)([O-])[O-])ccc12>>CC(=O)c1cn(CC(=O)N2[C@@H]3CCC[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(P(=O)(O)O)ccc12,,ClCCl,,C[Si](C)(C)Br,,val
US20140275179A1,O=C(O)c1c(C(F)(F)F)nsc1Br>>OCc1c(C(F)(F)F)nsc1Br,,C1CCOC1,,,,val
US20030212276A1,CCS.COc1cc2c(Nc3cc(OC)c(Cl)cc3Cl)c(C#N)cnc2cc1F>>CCSc1cc2ncc(C#N)c(Nc3cc(OC)c(Cl)cc3Cl)c2cc1OC,,C1CCOC1,,[H-].[Na+],,val
US20060079519A1,CCc1c(C(=O)CBr)cnn1-c1ccccc1.COC(=O)c1ccc(C)c(N)c1>>CCc1c(C(=O)CNc2cc(C(=O)OC)ccc2C)cnn1-c1ccccc1,,CCO,,,,val
US20030013875A1,CCCCCCN1CC2C(C1)C2(C)c1cccc(N)c1.COCCS(=O)(=O)Cl>>CCCCCCN1CC2C(C1)C2(C)c1cccc(NS(=O)(=O)CCOC)c1,,ClCCl,,c1ccncc1,,val
US20100016279A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.Clc1ccc(Cl)nn1>>CC(C)(C)OC(=O)N1CC=C(c2ccc(Cl)nn2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])O.[Na+],,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OCc3ccccc3)c(C(=O)O)c2)=C(C)C1=O.COc1ccc(N)cc1>>COC1=C(OC)C(=O)C(Cc2ccc(OCc3ccccc3)c(C(=O)Nc3ccc(OC)cc3)c2)=C(C)C1=O,,ClCCl,,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US06228870B1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCCBr>>CC(C)(C)OC(=O)C(N)CCBr,,ClCCl,,Br,CCN(CC)CC,val
US20160214997A1,CCN(CC)S(F)(F)F.COc1ccc(CNc2nc3c4c(ccc3c3nc(CCN5CCCC(O)(C(F)(F)F)C5)nn23)OC(F)(F)O4)c(OC)c1>>COc1ccc(CNc2nc3c4c(ccc3c3nc(CCN5CCCC(F)(C(F)(F)F)C5)nn23)OC(F)(F)O4)c(OC)c1,,ClCCl,,,,val
US04866091,CC(=O)c1ccc([N+](=O)[O-])c(Cl)c1.Oc1cccc(Cl)c1>>CC(=O)c1ccc([N+](=O)[O-])c(Oc2cccc(Cl)c2)c1,,Cc1ccccc1C,,O=C([O-])[O-].[K+].[K+],,val
US20050101584A1,CC[Mg]Br.O=C1c2ccc(OCc3ccccc3)cc2C(=O)N1c1ccc(OCc2ccccc2)cc1>>CCC1(O)c2cc(OCc3ccccc3)ccc2C(=O)N1c1ccc(OCc2ccccc2)cc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20090156572A1,COC(=O)c1ccc([C@@H]2CN(C(=O)C3CCN(C(C)=O)CC3)CC[C@H]2N(C)C(=O)c2ccc(OC)cc2)cc1>>COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(C(=O)O)cc2)cc1,,CO,,[Na+].[OH-],,val
US20120157448A1,NC1=NC2(CO1)c1cc(Br)ccc1OC1CCCCC12.OB(O)c1cncc(Cl)c1>>NC1=NC2(CO1)c1cc(-c3cncc(Cl)c3)ccc1OC1CCCCC12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US06884821B1,COc1ccccc1C[NH-].O=C(O)c1ccc(C(F)(F)F)cc1>>COc1ccccc1CNC(=O)c1ccc(C(F)(F)F)cc1,,CN(C)C=O,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20060211728A1,CC(C)(C)OC(=O)NC1CCC(=O)NC1=O.O=C(O)C(F)(F)F>>NC1CCC(=O)NC1=O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20030199528A1,Cn1c(=O)[nH]c(=O)c2c1nc(Br)n2Cc1ccccc1Cl.N#Cc1ccccc1CBr>>Cn1c(=O)n(Cc2ccccc2C#N)c(=O)c2c1nc(Br)n2Cc1ccccc1Cl,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050130954A1,CCOC(=O)c1ccc(-c2ccncc2)cc1.Cl>>Cl.O=C(O)c1ccc(-c2ccncc2)cc1,,O,,,,val
US20140323475A1,COC(=O)c1cccc2c1CCN2.Fc1cc(Cl)ccc1COc1ccc(Cl)cc1CBr>>COC(=O)c1cccc2c1CCN2Cc1cc(Cl)ccc1OCc1ccc(Cl)cc1F,,CN(C)C=O,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20140213574A1,CC(C)(C)OC(=O)Nc1cccc(Oc2nc(S(C)(=O)=O)ncc2C(=O)Nc2ccccc2)c1.COc1cccc(N)c1>>COc1cccc(Nc2ncc(C(=O)Nc3ccccc3)c(Oc3cccc(NC(=O)OC(C)(C)C)c3)n2)c1,,CC(=O)N(C)C,,,,val
US05166204,Cn1c(C(C)(C)O)cc2ccccc21>>C=C(C)c1cc2ccccc2n1C,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20130267565A1,Cc1cc(N(C)C(=O)OC(C)(C)C)ccc1Oc1ccc(NC(=O)c2ccc(C(F)(F)F)cc2)cn1>>CNc1ccc(Oc2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cn2)c(C)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060154928A1,CCCCCCCCCCCCC=O.COc1ccc(CCNC(=N)NC(=N)N)cc1.Cl>>CCCCCCCCCCCCC1N=C(N)NC(NCCc2ccc(OC)cc2)=N1.Cl,,CCO,,Cl,,val
US20050107377A1,BrCCCOc1ccc(-c2csc3ccccc23)cc1.c1ccc2c(c1)CCNC2>>c1ccc2c(c1)CCN(CCCOc1ccc(-c3csc4ccccc34)cc1)C2,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080275233A1,COC(=O)c1cccc(N2CC(=O)N(c3ccc(C(C)C)cc3)C2=O)c1>>CC(C)c1ccc(N2C(=O)CN(c3cccc(C(=O)O)c3)C2=O)cc1,,c1ccncc1,,[I-].[Li+],,val
US20150045339A1,C1COCCN1.CC(C)(C)OC(=O)/C=C/CI>>CC(C)(C)OC(=O)/C=C/CN1CCOCC1,,C1CCOC1,,CCOC(C)=O,O=C([O-])O.[Na+],val
US04110447,CC(=O)NCCC(C)(O)c1ccccc1-c1ccccc1>>CC(=O)NCC=C(C)c1ccccc1-c1ccccc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070135440A1,Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1cnc(S(C)(=O)=O)nc1.OCc1cscn1>>Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1cnc(OCc2cscn2)nc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US04436748,COc1cc2cc(-c3ccccc3Cl)sc2c(Cl)c1Cl>>Oc1cc2cc(-c3ccccc3Cl)sc2c(Cl)c1Cl,,O,,Cl,c1ccncc1,val
US20060211693A1,CC(C)(C)OC(=O)N1CCN(CCO)C(=O)C1.Cl>>Cl.O=C1CNCCN1CCO,,C1COCCO1,,,,val
US20090286765A1,C=C[Mg]Br.CCCS(=O)(=O)c1ccc(/C=N/S(=O)C(C)(C)C)cc1>>C=CC(NS(=O)C(C)(C)C)c1ccc(S(=O)(=O)CCC)cc1,,C1CCOC1,CCCCCC,CCOC(C)=O,,val
US20110092490A1,COc1cccc(-c2nc(Cl)nc(Cl)n2)c1.Nc1ccc(O)cc1>>COc1cccc(-c2nc(Cl)nc(Nc3ccc(O)cc3)n2)c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20090023710A1,CC(=O)Cl.Clc1ccc(Oc2ccccc2NC2CCNCC2)c(Cl)c1>>CC(=O)N1CCC(Nc2ccccc2Oc2ccc(Cl)cc2Cl)CC1,,ClCCl,,CCN(CC)CC,,val
US20130338190A1,CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/[C@H]1CCCN1C.O=C(O)/C=C\C(=O)O>>CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/[C@H]1CCCN1C.O=C(O)/C=C\C(=O)O,,ClCCl,,,,val
US06288061B1,CCOC(=O)c1nc(-c2ccc([N+](=O)[O-])c(C)c2)[nH]c1-c1ccc(OC)cc1>>COc1ccc(-c2[nH]c(-c3ccc([N+](=O)[O-])c(C)c3)nc2C(=O)O)cc1,,CCO,,[Na+].[OH-],,val
US20150291640A1,CCOC(=O)C(O[C@@H]1C=C[C@H](OC(C)=O)C1)P(=O)(OCC)OCC.Cc1c[nH]c(=O)[nH]c1=O>>CCOC(=O)C(O[C@H]1C=C[C@@H](n2cc(C)c(=O)[nH]c2=O)C1)P(=O)(OCC)OCC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US05576340,COC(=O)Cc1ccc(OCC(C)=O)cc1.NCC(O)c1cccc(Cl)c1>>COC(=O)Cc1ccc(OCC(C)NCC(O)c2cccc(Cl)c2)cc1,,c1ccccc1,,O,,val
US07001917B2,COC(=O)c1cccc(-c2c(C)nn(-c3ccc(CCOS(C)(=O)=O)cc3)c2C)c1.[N-]=[N+]=[N-]>>COC(=O)c1cccc(-c2c(C)nn(-c3ccc(CCN=[N+]=[N-])cc3)c2C)c1,,CN(C)C=O,,O,,val
US20080146818A1,BrCc1ccccc1.N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)O)(CC1)CC2>>N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)OCc3ccccc3)(CC1)CC2,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20160206616A1,CCOC(=O)C1=C(CBr)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br.O=C(O)CCCC[C@@H]1CC(F)(F)CN1>>CCOC(=O)C1=C(CN2CC(F)(F)C[C@H]2CCCCC(=O)O)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20140088094A1,Nc1ccc2c(c1)N(S(=O)(=O)c1ccc(Cl)cc1)CCC2.O=C(Cl)c1c(F)cccc1Cl>>O=C(Nc1ccc2c(c1)N(S(=O)(=O)c1ccc(Cl)cc1)CCC2)c1c(F)cccc1Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040192686A1,COc1ccc2c(c1)nc(Cl)n[n+]2[O-].NCCN1CCCCC1>>COc1ccc2c(c1)nc(NCCN1CCCCC1)n[n+]2[O-],,COCCOC,,,,val
US20030033089A1,CC(C)I.O=c1nc(-c2ccccc2)c2cc3c(cc2[nH]1)OCCO3>>CC(C)Oc1nc(-c2ccccc2)c2cc3c(cc2n1)OCCO3,,CN(C)C=O,,[H-].[Na+],,val
US20130059847A1,C=CC(=O)Nc1cccc(-c2nc(Nc3ccc(N4CCOCC4)cc3)nc3c2cnn3C2CCCCO2)c1>>C=CC(=O)Nc1cccc(-c2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]ncc23)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140179680A1,CCOC(OCC)OCC.C[C@@H]1CC[C@@H](CNc2c(N)cc(Cl)nc2Cl)CC1>>C[C@@H]1CC[C@@H](Cn2cnc3cc(Cl)nc(Cl)c32)CC1,,CC(=O)OC(C)=O,,,,val
US20140303143A1,CC(C)(C)OC(=O)N1Cc2c(CO)cccc2C(F)C1.COc1ccc(CN(c2ncns2)S(=O)(=O)c2cc3oc(=O)[nH]c3cc2F)c(OC)c1>>COc1ccc(CN(c2ncns2)S(=O)(=O)c2cc3oc(=O)n(Cc4cccc5c4CN(C(=O)OC(C)(C)C)CC5F)c3cc2F)c(OC)c1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110269774A1,CCn1nc(CN(C)C)cc1N.CNC(=O)c1cccc(F)c1Nc1cc(Cl)ncc1Cl>>CCn1nc(CN(C)C)cc1Nc1cc(Nc2c(F)cccc2C(=O)NC)c(Cl)cn1,,C1COCCO1,,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20140179680A1,C[C@H]1CC[C@H](Cn2c(N3CCC[C@H]3C(F)(F)F)nc3cc(C#N)nc(-c4cncc(Cl)c4)c32)CC1.[N-]=[N+]=[N-]>>C[C@H]1CC[C@H](Cn2c(N3CCC[C@H]3C(F)(F)F)nc3cc(-c4nnn[nH]4)nc(-c4cncc(Cl)c4)c32)CC1,,CN(C)C=O,,[Cl-].[NH4+],,val
US03966736,CCN(CC)CC(=O)N1c2cc(Br)c(Br)cc2NC(=O)c2cccnc21.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CCN(CC)CC(=O)N1c2cc(Br)c(Br)cc2NC(=S)c2cccnc21,,c1ccncc1,,,,val
US20080119470A1,O=C(O)c1c(Cl)cc(Cl)c(O)c1[N+](=O)[O-]>>Nc1c(O)c(Cl)cc(Cl)c1C(=O)O,[Fe],CC(=O)O,,,,val
US20070010678A1,CN(C)CCC(O)c1ccccc1.Cc1ccccc1I>>Cc1ccccc1OC(CCN(C)C)c1ccccc1,,COC(C)(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040267028A1,N#CCC(=O)NC1CCCCC1.O=C(CBr)c1ccc(Cl)cc1>>N#CC(CC(=O)c1ccc(Cl)cc1)C(=O)NC1CCCCC1,,CO,,C[O-].[Na+],,val
US20120252807A1,C[C@@H](N)c1ccccc1.O=CC1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(F)cc2)CC1>>C[C@@H](NCC1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(F)cc2)CC1)c1ccccc1,,C1CCOC1,,CC(=O)O,[BH3-]C#N.[Na+],val
US20120046467A1,CC(C)[N+](=O)[O-].O=[N+]([O-])c1ccc(CCl)cc1>>CC(C)(Cc1ccc([N+](=O)[O-])cc1)[N+](=O)[O-],,CCO,,C,C[O-].[Na+],val
US20020143007A1,CC(C)(S)CN.O=C1CCCC(=O)O1>>CC(C)(S)CNC(=O)CCCC(=O)O,,ClCCl,,CCN(CC)CC,Cl,val
US20150133510A1,CN(C)c1ccc(CN(Cc2ccccc2)Cc2ccc(N(C)C)cc2)cc1.CS(=O)(=O)O>>CN(C)c1ccc(C[NH+](Cc2ccccc2)Cc2ccc(N(C)C)cc2)cc1.CS(=O)(=O)[O-],,CCOCC,,,,val
US03950380,CCCCI.CCCCO.Nc1cc(C(=O)O)cc(S(N)(=O)=O)c1-c1ccccc1>>CCCCNc1cc(C(=O)OCCCC)cc(S(N)(=O)=O)c1-c1ccccc1,,CCCCO,,O,,val
US04927838,CCCCc1c(/C=C/C(=O)O)cc(OC)c2ccccc12.O=[N+]([O-])c1ccc(O)cc1>>CCCCc1c(/C=C/C(=O)Oc2ccc([N+](=O)[O-])cc2)cc(OC)c2ccccc12,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100331301A1,CCc1ccc(COc2ccc(C3CN(C(=O)c4cc(OCCO)ccn4)C3)cc2OC)cc1.CS(=O)(=O)Cl>>CCc1ccc(COc2ccc(C3CN(C(=O)c4cc(OCCOS(C)(=O)=O)ccn4)C3)cc2OC)cc1,,C1CCOC1,,CCN(CC)CC,O,val
US20120277208A1,CC(C)Oc1cc(Oc2cnc(NCC3CC3)cn2)cc(C(=O)Nc2ccn(C)n2)c1.O=C(O)C1CCOCC1>>CC(C)Oc1cc(Oc2cnc(N(CC3CC3)C(=O)C3CCOCC3)cn2)cc(C(=O)Nc2ccn(C)n2)c1,CN(C)c1ccncc1,ClCCl,O,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20100216798A1,CCO[C@@H]1CC[C@@H](Nc2ccc3nc(C#N)c(-c4ccncc4)n3n2)CC1.OO>>CCO[C@@H]1CC[C@@H](Nc2ccc3nc(C(N)=O)c(-c4ccncc4)n3n2)CC1,,CCO,CS(C)=O,[Na+].[OH-],,val
US20080161295A1,CC(O)Br.O=S1(=O)NCc2ccccc2N1c1ccccc1F>>O=S1(=O)N(CCBr)Cc2ccccc2N1c1ccccc1F,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04294841,Clc1ccccc1.O=C(O)CCC1CCN(C(=O)c2ccccc2)CC1>>O=C(CCC1CCN(C(=O)c2ccccc2)CC1)c1ccc(Cl)cc1,,S=C=S,,,,val
US20050130954A1,CC(C)(C)OC(=O)N1CCNCC1.Nc1c(Cl)ncnc1Cl>>CC(C)(C)OC(=O)N1CCN(c2ncnc(Cl)c2N)CC1,,Cc1ccccc1,,,,val
US20130317001A1,CC(C)(C)OC(=O)c1cc(Cl)c(F)cc1F.CC1(CO)CCC(F)(F)CC1>>CC1(COc2cc(F)c(C(=O)OC(C)(C)C)cc2Cl)CCC(F)(F)CC1,,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140045746A1,CCOC(=O)C1C2Cc3cc(OC)ncc3C21>>CCOC(=O)C1C2Cc3cc(O)ncc3C21,,CC#N,,C[Si](C)(C)Cl,[I-].[Na+],val
US20090181965A1,CCOC(=O)C1CCCC(Br)C1=O.COc1cc(NC(N)=S)ccc1-n1cnc(C)c1>>CCOC(=O)C1CCCc2sc(Nc3ccc(-n4cnc(C)c4)c(OC)c3)nc21,,CCO,,,,val
US20080167334A1,CC(C)(C)OC(=O)NCCc1ccc2c(c1)C1C=CCC1C(c1cc3c(cc1Br)OCO3)N2>>NCCc1ccc2c(c1)C1C=CCC1C(c1cc3c(cc1Br)OCO3)N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040116465A1,CCOc1ccc(Cc2nc3cc(C(=O)N4CCCC4)ccc3n2CC2CC2)cc1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CCOc1ccc(Cc2nc3cc(C(=S)N4CCCC4)ccc3n2CC2CC2)cc1,,c1ccncc1,,,,val
US05977105,O[C@H](CCc1cccnc1)COc1ccc(-c2cccc(OCc3ccccc3)c2)cc1>>Oc1cccc(-c2ccc(OC[C@H](O)CCc3cccnc3)cc2)c1,[Pd],CCO,,,,val
US20070219210A1,CCOC(=O)c1cc(-c2cnc(C)cn2)n(-c2ccc(C)nc2)n1>>Cc1ccc(-n2nc(C(=O)O)cc2-c2cnc(C)cn2)cn1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20110269791A1,C[C@H]1[C@H]2Cc3ccc(OS(=O)(=O)C(F)(F)F)cc3[C@]1(C)CCN2C(=O)[C@@H]1COc2ccccc2O1>>C[C@H]1[C@H]2Cc3ccccc3[C@]1(C)CCN2C(=O)[C@@H]1COc2ccccc2O1,[Pd],CCOC(C)=O,CO,,,val
US20060058282A1,COc1ccc(C2(C(=O)O)CCCCC2)cc1.O=C(Cl)C(=O)Cl>>COc1ccc(C2(C(=O)Cl)CCCCC2)cc1,CN(C)C=O,ClCCl,,,,val
US20110184029A1,COC(=O)c1cc(C#N)cc(C=O)c1.COc1nc(C)c(CC2CC2)c(Br)c1C(C)C>>COC(=O)c1cc(C#N)cc(C(O)c2c(CC3CC3)c(C)nc(OC)c2C(C)C)c1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20150376136A1,CN1CC(C)(C2=CCCCC2)C(=O)N(C(C)(C)CC(C)(C)C)C1=O>>CN1CC(C)(C2=CCCCC2)C(=O)NC1=O,,CCO,,Cl,,val
US20110015178A1,CCOC(=O)c1cc(-c2ccccc2)sc1N>>CCOC(=O)c1csc(-c2ccccc2)c1,Cl[Cu]Cl,[Cl-],[NH4+],CC(C)(C)ON=O,,val
US20100286088A1,COc1ccc(CN=C=O)cc1OC.[N-]=[N+]=C1N=CN=C1C(N)=O>>COc1ccc(Cn2nnc3c(C(N)=O)ncn3c2=O)cc1OC,,CS(C)=O,,,,val
US20150057265A1,CC(C)(C)OC(=O)Nc1sc2ccc(-c3ccccc3)nc2c1C(=O)O.Cn1ncc(N)c1N1CCCC(NC(=O)OC(C)(C)C)CC1>>Cn1ncc(NC(=O)c2c(NC(=O)OC(C)(C)C)sc3ccc(-c4ccccc4)nc23)c1N1CCCC(NC(=O)OC(C)(C)C)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060063805A1,CC(C)(C)OC(=O)NC1CC1c1ccc(F)cc1>>NC1CC1c1ccc(F)cc1,,C1COCCO1,,Cl,,val
US20050096309A1,CC(C)N1CCC(N2CCC[C@H](NS(=O)(=O)C=Cc3ccc(Cl)s3)C2=O)CC1>>CC(C)N1CCC(N2CCC[C@H](NS(=O)(=O)CCc3cccs3)C2=O)CC1,[Pd],CO,,,,val
US20120083475A1,C=CC1CCCCC1.CCOC(=O)C[N+](=O)[O-]>>CCOC(=O)C1=NOC(c2ccccc2)C1,,CCO,,C1CN2CCN1CC2,,val
US20110039855A1,CC(C)OC(=O)N[C@H]1Cc2c(n(C[C@H]3NCC[C@@H]3O)c3ccc(C#N)cc23)C1.CC=O>>CCN1CC[C@H](O)[C@H]1Cn1c2c(c3cc(C#N)ccc31)C[C@H](NC(=O)OC(C)C)C2,,CC#N,ClCCl,O=C([O-])O.[Na+],,val
US20110144105A1,Cc1cnc2[nH]ccc2c1.O=S(=O)(Cl)c1ccccc1>>Cc1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US04382090,CN(C)C(=O)CC#N.S>>CN(C)C(=O)CC(N)=S,,CCN(CC)CC,,,,val
US20120022115A1,Cc1cc(C2CCCCC2)n(O)c(=O)c1.O=C(Cl)c1ccccc1>>Cc1cc(C2CCCCC2)n(OC(=O)c2ccccc2)c(=O)c1,CN(C)c1ccncc1,ClCCl,,,,val
US04105772,Cn1cc(C=O)c([N+](=O)[O-])n1.NC(=O)CC(=O)O>>Cn1cc(C=C(C(N)=O)C(=O)O)c([N+](=O)[O-])n1,,c1ccncc1,,,,val
US20100120739A1,O=C(Cc1c(F)cc2ncccc2c1F)NNc1ccc(Cl)nn1>>Fc1cc2ncccc2c(F)c1Cc1nnc2ccc(Cl)nn12,,CC(=O)O,,,,val
US20020035266A1,COC(=O)/C(=C/C1CCCCCC1)c1ccc(-n2nnnc2C)c(Cl)c1>>Cc1nnnn1-c1ccc(/C(=C\C2CCCCCC2)C(=O)O)cc1Cl,,CCO,,[Na+].[OH-],,val
US05334576,CC=Cc1cnc(C2=NC(C)(C(C)C)C(=O)N2)c(C(=O)OC)c1>>CC=Cc1cnc(C2=NC(C)(C(C)C)C(=O)N2)c(C(=O)O)c1,,CO,,Cl,[Na+].[OH-],val
US20090099227A1,COC(=O)C(C)(C)OC(=O)N1CCC(Cc2noc(-c3cc4cnccc4o3)n2)CC1>>CC(C)(OC(=O)N1CCC(Cc2noc(-c3cc4cnccc4o3)n2)CC1)C(=O)O,,C1CCOC1,O,[Li]O,,val
US04650804,CCOC(=O)c1cc(O[Si](C)(C)C(C)(C)C)c2ccccn2c1=O>>CCOC(=O)c1cc(O)c2ccccn2c1=O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160145247A1,CNc1cccc(Br)c1.COC(=O)Cc1ccccc1C=O>>COC(=O)Cc1ccccc1CN(C)c1cccc(Br)c1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20050171099A1,OC(c1ccsc1)c1ccsc1>>O=C(c1ccsc1)c1ccsc1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20150111877A1,COC(=O)c1cnc2c(c1)NC(=O)[C@H](C)O2>>C[C@@H]1Oc2ncc(C(=O)O)cc2NC1=O,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US05134231,C=C=O.CC(CSc1ccccc1)C(=CC(=O)OCc1ccc([N+](=O)[O-])cc1)NCc1ccccc1>>CC(=O)C(C(=O)OCc1ccc([N+](=O)[O-])cc1)=C(NCc1ccccc1)C(C)CSc1ccccc1,,Cc1ccccc1,,,,val
US06172085B2,Cc1c(C)c2c(c(C)c1N)CC(C)(CBr)O2.c1ccc2c(c1)CCNC2>>Cc1c(C)c2c(c(C)c1N)CC(C)(CN1CCc3ccccc3C1)O2,,CC(=O)N(C)C,O,O=C([O-])[O-].[K+].[K+],,val
US20100190766A1,COC(=O)c1ccc(C#CC#CC(C)N2CCOCC2)cc1>>CC(C#CC#Cc1ccc(C(=O)O)cc1)N1CCOCC1,,C1CCOC1,,CO,O,val
US20070066618A1,CCC(=O)O.CCC(=O)OC(=O)CC.Cc1cc(Nc2ccc(CCO)cc2)c(N)c(C)n1>>CCC(=O)OCCc1ccc(-n2c(CC)nc3c(C)nc(C)cc32)cc1,,[Na+],[OH-],,,val
US20110152240A1,Nc1cccc(Cl)c1.O=C1NC(=O)C(=Cc2cnn3c(NC4CC4)cc(Cl)nc23)S1>>O=C1NC(=O)C(=Cc2cnn3c(NC4CC4)cc(Nc4cccc(Cl)c4)nc23)S1,,CN1CCCC1=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070185324A1,Cc1c(Br)cc2c(Cl)ncnc2c1[N+](=O)[O-].Nc1cccc(C(F)(F)F)c1>>Cc1c(Br)cc2c(Nc3cccc(C(F)(F)F)c3)ncnc2c1[N+](=O)[O-],,CC(C)O,,,,val
US20160145208A1,CC(C)(C)OC(=O)C1=CN([Si](C)(C)C)[C@@H](C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)[C@@H]1C[C@H](C(=O)OC(C)(C)C)N([Si](C)(C)C)C1,[Pd],CO,,,,val
US20040171597A1,CC1(C)OCc2cc([C@@H]3CN(CCCCCCOCCC#Cc4cccc(S(N)(=O)=O)c4)C(=O)O3)ccc2O1>>CC1(C)OCc2cc([C@@H]3CN(CCCCCCOCCCCc4cccc(S(N)(=O)=O)c4)C(=O)O3)ccc2O1,O=[Pt],C1CCOC1,,,,val
US20090093456A1,COc1ccc(-c2cc3c(s2)C(=O)N(c2ccc(O)c(OC)c2)CC3)cc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc(-c2cc3c(s2)C(=O)N(c2ccc(OS(=O)(=O)C(F)(F)F)c(OC)c2)CC3)cc1,,c1ccncc1,,,,val
US20050148624A1,COC(=O)c1ccc2c(=O)n(Cc3ccc(C(=O)OC(C)(C)C)cc3)c(C(=O)OC)c(-c3ccccc3)c2c1>>COC(=O)c1c(-c2ccccc2)c2cc(C(=O)O)ccc2c(=O)n1Cc1ccc(C(=O)OC(C)(C)C)cc1,,C1CCOC1,,CO,[Na+].[OH-],val
US05158949,C=CCBr.Clc1ccc(CCBr)cc1>>C=CCCCc1ccc(Cl)cc1,,CCOCC,,[Mg],,val
US20100081643A1,Nc1cc(F)c(-c2ccc(-c3ccccc3)cc2)cc1N.S=C=S>>Fc1cc2[nH]c(=S)[nH]c2cc1-c1ccc(-c2ccccc2)cc1,,CC(=O)O,O,CCO,[K+].[OH-],val
US20140142298A1,BrCc1ccccc1.CC(C)(C)OC(=O)N1CCN2CCN(C(=O)OC(C)(C)C)C2C1>>CC(C)(C)OC(=O)N1CC[N+]2(Cc3ccccc3)CCN(C(=O)OC(C)(C)C)C2C1.[Br-],,CC#N,,,,val
US20060258691A1,CN(C)C=O.Cc1ccc(C(=O)Nc2ncc3c(I)cn(C(C)(C)C)c3n2)cc1.NCc1cccnc1>>Cc1ccc(CNc2ncc3c(C(=O)NCc4cccnc4)cn(C(C)(C)C)c3n2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,,,,val
US20140228361A1,CC(C)(C)OC(=O)N1CCC2CCNCC2C1.CCC(Cl)Br>>CC(C)(C)OC(=O)N1CCC2CCN(CCCCl)CC2C1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130253204A1,CC(C)(C)OC(=O)N1OC1C(Cl)(Cl)Cl.CC(C)(N)Cc1ccc(C(F)(F)F)cc1>>CC(C)(Cc1ccc(C(F)(F)F)cc1)NNC(=O)OC(C)(C)C,,ClCCl,,,,val
US20060116410A1,CS(=O)(=O)N(CC(N)=O)c1cc(Cl)cc(C(=O)NCc2ccc(C#N)cc2[N+](=O)[O-])c1>>CS(=O)(=O)N(CC(N)=O)c1cc(Cl)cc(C(=O)NCc2ccc(C#N)cc2N)c1,[Pd],CCOC(C)=O,,,,val
US20140235689A1,Cc1nn(C)c(Br)c1-c1c(F)cccc1F.O=Cc1ccc(F)cc1F>>Cc1nn(C)c(C(O)c2ccc(F)cc2F)c1-c1c(F)cccc1F,,C1CCOC1,,[Li]CCCC,,val
US20040019016A1,COc1cc(C=O)ccc1S(=O)(=O)N(C)C>>COc1cc(CO)ccc1S(=O)(=O)N(C)C,,C1CCOC1,,[BH4-].[Na+],,val
US20150183801A1,O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(Br)c1.OC1CCCNC1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCCC(O)C2)c(Br)c1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US06337344B1,Cc1cccc2[nH]c(C(=O)O)cc12.N#Cc1cccc(CBr)c1>>Cc1cccc2[nH]c(C(=O)OCc3cccc(C#N)c3)cc12,,CN(C)C=O,,,,val
US05480993,CCOC(=O)c1cnn(C)c1S(=O)(=O)NC(=O)[n+]1ccccc1.COc1cc(OC)nc(N)n1>>CCOC(=O)c1cnn(C)c1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC)n1,,CC#N,,O,,val
US20090221555A1,CC(=O)OC(C)=O.O=C1CCNc2ccccc2CN1>>CC(=O)N1CCC(=O)NCc2ccccc21,,CC#N,,,,val
US20100310512A1,CC(C)(C)OC(=O)N1CCCC1CN.O=C(O)c1ccc(Br)cc1>>CC(C)(C)OC(=O)N1CCCC1CNC(=O)c1ccc(Br)cc1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150299146A1,CC(=O)c1cccc(O)c1.CCCCCCBr>>CCCCCCOc1cccc(C(C)=O)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160039788A1,O=C1CCc2cc(/C=C/CCBr)cnc2N1>>O=C1CCc2cc(CCCCBr)cnc2N1,[Rh],CCO,,,,val
US20090093454A1,CN(C)CCCCl.c1cnc2c(c1)CC[C@@H]1CCN(Cc3nc4ccccc4[nH]3)[C@@H]21>>CN(C)CCCn1c(CN2CC[C@H]3CCc4cccnc4[C@@H]32)nc2ccccc21,,CN(C)C=O,,[I-].[K+],,val
US20070238765A1,COC(=O)c1ncnn1Cc1c2cccc(-c3ccc(Cl)cc3Cl)c2nn1C.N>>Cn1nc2c(-c3ccc(Cl)cc3Cl)cccc2c1Cn1ncnc1C(N)=O,,CO,,[C-]#N.[Na+],,val
US20080058377A1,CC(C)(C)OC(=O)Nc1ccc2ccc(O)cc2c1.CCI>>CCOc1ccc2ccc(NC(=O)OC(C)(C)C)cc2c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050277670A1,COc1ccc(C(=O)C2CCN(C(=O)OC(C)(C)C)CC2)cc1.Oc1ccccc1O>>COc1ccc(C2(C3CCNCC3)Oc3ccccc3O2)cc1,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140235629A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CC[C@@H](COCc1ccc(OC)c(OC)c1)N1C(=O)CO[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1>>CC[C@@H](CO[Si](C)(C)C(C)(C)C)N1C(=O)CO[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20110112103A1,CC(C)(C)OC(=O)N1CCC(CC#N)CC1.NO>>CC(C)(C)OC(=O)N1CCC(CC(N)=NO)CC1,,CCO,,,,val
US04537621,CN.O=[N+]([O-])c1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1SCl>>CNS.O=[N+]([O-])c1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1,,CCOCC,,,,val
US20070129347A1,CN(C)C1(c2ccccc2)CCC(CC(=O)NCCc2c[nH]c3ccccc23)CC1.C[Si](C)(C)Cl>>CN(C)C1(c2ccccc2)CCC(CC(=O)NCCc2c[nH]c3ccccc23)CC1.Cl,,CCC(C)=O,,,,val
US04013645,CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC=O)[C@H]2SC1>>CC(=O)OCC1=CS[C@@H]2[C@H](NC=O)C(=O)N2[C@H]1C(=O)O,,c1ccncc1,,CC(=O)OC(C)=O,,val
US20030149001A1,CCOCc1cc2cnc(SC)nc2n(C2CCCC2)c1=O.O=S(=O)(c1ccccc1)N1OC1c1ccccc1>>CCOCc1cc2cnc(S(C)=O)nc2n(C2CCCC2)c1=O,,ClCCl,,,,val
US20150158846A1,Nc1ccnc(Cl)n1.O=C(O)C1CCNC1>>Nc1ccnc(N2CCC(C(=O)O)C2)n1,,CC(C)O,,,,val
US20130190316A1,COc1cc(C=O)c(OCc2cccnc2Br)cn1.Cc1cnn(C2CCCCO2)c1B(O)O>>COc1cc(C=O)c(OCc2cccnc2-c2c(C)cnn2C2CCCCO2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120115841A1,CS(=O)(=O)Cl.OCc1nc(Br)cs1>>CS(=O)(=O)OCc1nc(Br)cs1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,N#N,val
US20150266879A1,C=O.CCOC(=O)c1cc2cccnc2[nH]1.CNC>>CCOC(=O)c1[nH]c2ncccc2c1CN(C)C,,CCO,,CC(=O)O,Cl,val
US05112743,CC(=O)OCC(C)(COC(C)=O)C(=O)Nc1ccc(S(N)(=O)=O)cc1>>CC(CO)(CO)C(=O)Nc1ccc(S(N)(=O)=O)cc1,,O,,CCO,[Na+].[OH-],val
US06008230,CCOC(=O)c1cnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1C(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>CCOC(=O)c1cnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1CC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160083391A1,Br[Mg]C1CCCC1.CON(C)C(=O)CCl>>O=C(CCl)C1CCCC1,,C1CCOC1,,,,val
US20100130739A1,CCOC(=O)CN.Clc1nccnc1Cl>>CCOC(=O)CNc1nccnc1Cl,,CCN(CC)CC,,CCO,Cl,val
US20030050330A1,CSc1ccc(C(C#N)O[Si](C)(C)C)cc1.O=Cc1cccnc1>>CSc1ccc(C(=O)C(O)c2cccnc2)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20110039847A1,O=C(c1nccs1)c1ccccc1[N+](=O)[O-]>>Nc1ccccc1C(=O)c1nccs1,[Fe],CC(C)O,O,[Cl-].[NH4+],,val
US20110092516A1,CCOc1ncccc1C1(O)C(=O)Nc2ccc(Cl)cc21.O=S(Cl)Cl>>CCOc1ncccc1C1(Cl)C(=O)Nc2ccc(Cl)cc21,,ClCCl,,c1ccncc1,,val
US20150038515A1,CCOC(=O)CN(c1cc(C(F)(F)F)ccc1Cl)S(=O)(=O)c1ccc(C)cc1>>Cc1ccc(S(=O)(=O)N(CC(=O)O)c2cc(C(F)(F)F)ccc2Cl)cc1,,CO,,O,[Na+].[OH-],val
US04316913,CC1(C)C(C=C(Cl)c2ccc(OC(F)(F)F)cc2)C1C(=O)Cl.OCc1ccc(F)c(Oc2ccccc2)c1>>CC1(C)C(C=C(Cl)c2ccc(OC(F)(F)F)cc2)C1C(=O)OCc1ccc(F)c(Oc2ccccc2)c1,,Cc1ccccc1,O,Cl,c1ccncc1,val
US20070167433A1,CCOC[C@H](C)CO.COCCCN1CCOc2ccc(C(O[C@H]3CNC[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]3c3ccc(CCl)cc3)S(=O)(=O)c3ccc(C)cc3)cc21>>CCOC[C@H](C)COCc1ccc([C@H]2[C@H](O[Si](C(C)C)(C(C)C)C(C)C)CNC[C@@H]2OC(c2ccc3c(c2)N(CCCOC)CCO3)S(=O)(=O)c2ccc(C)cc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US04727082,COC(=O)/C=C(/C)N.COC(=O)CC(C)=O.O=Cc1cc([N+](=O)[O-])ccc1OC/C=C/CCl>>COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cc([N+](=O)[O-])ccc1OC/C=C/CCl,,CC(C)O,,,,val
US20080070919A1,C1=CC[C@H]2CN[C@@H](C1)CN2c1ccc2c(c1)Cc1ccccc1-2.Clc1ccc2c(OC[C@@H]3CO3)ccnc2c1>>O[C@H](COc1ccnc2cc(Cl)ccc12)CN1CC2CC=CCC1CN2c1ccc2c(c1)Cc1ccccc1-2,,CCO,,CCN(C(C)C)C(C)C,,val
US20130217732A1,CN1CCCC1=O.Cc1c(NC(=O)C(C)(C)C)ccc(Cl)c1C(F)(F)F>>Cc1c(NC(=O)C(C)(C)C)ccc(C#N)c1C(F)(F)F,,O,,,,val
US20020193385A1,CC1(C)OB(c2cc([N+](=O)[O-])ccc2F)OC1(C)C.Fc1c(Br)nc(Br)c(F)c1Br>>O=[N+]([O-])c1ccc(F)c(-c2nc(Br)c(F)c(Br)c2F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20080255155A1,COc1ccc(O)cn1.O=[N+]([O-])c1ccc(F)c(F)c1>>COc1ccc(Oc2ccc([N+](=O)[O-])cc2F)cn1,,CN1CCCC1=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150191461A1,O=CC1CC(=O)NC12CC2>>O=C1CC(CO)C2(CC2)N1,,CO,O,[BH4-].[Na+],,val
US20070135631A1,CC1(C)CO1.O=C(NC1CCCC1)N[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(F)c(O)c1>>CC(C)(O)COc1cc([C@@](Cc2ccccc2)(NC(=O)NC2CCCC2)c2cc(F)cc(C(F)(F)F)c2)ccc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070105943A1,N#CCC#N.Nc1sccc1C=O>>N#Cc1cc2ccsc2nc1N,C1CCNCC1,CCO,,,,val
US20100234395A1,COC(=O)Cn1c(C2CCN(C(=O)N(C)O)CC2)nc(-c2ccc(OC)cc2)c1-c1ccc(OC)cc1>>COc1ccc(-c2nc(C3CCN(C(=O)N(C)O)CC3)n(CC(=O)O)c2-c2ccc(OC)cc2)cc1,O,CO,,CC(=O)O,[Li+].[OH-],val
US20130072470A1,CC(F)(F)CN.CC[C@@H]1CNC[C@@H]1c1cnc2cnc3c(ccn3S(=O)(=O)c3ccc(C)cc3)n12.O=C(n1ccnc1)n1ccnc1>>CC[C@@H]1CN(C(=O)NCC(C)(F)F)C[C@@H]1c1cnc2cnc3c(ccn3S(=O)(=O)c3ccc(C)cc3)n12,,CC#N,CCOC(C)=O,Cl,O=C([O-])O.[Na+],val
US04873251,Nc1ccccc1.O=C(O)Cn1c(-c2ccc(Br)cc2)nc2cccnc21>>O=C(Cn1c(-c2ccc(Br)cc2)nc2cccnc21)Nc1ccccc1,,CN(C)C=O,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20150094328A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1ccc2[nH]cc(I)c2n1>>CC(C)(C)OC(=O)n1cc(I)c2nc(C#N)ccc21,CN(C)c1ccncc1,ClCCl,,,,val
US20070004695A1,COc1cccc(-c2nn(C)c3ccsc23)c1>>Cn1nc(-c2cccc(O)c2)c2sccc21,,ClCCl,,BrB(Br)Br,,val
US20140057902A1,CCCC[Sn](Cl)(CCCC)CCCC.Cc1cnco1>>CCCC[Sn](CCCC)(CCCC)c1ncc(C)o1,,CCOCC,,CCCCCC,[Li]CCCC,val
US20040157883A1,CC(=O)CCl.N=C(N)NC(N)=S>>Cc1csc(NC(=N)N)n1,,CC(C)=O,,,,val
US05117009,CCOC(=O)CCCCBr.O=c1c2ccccc2oc2ccc(O)cc12>>CCOC(=O)CCCCOc1ccc2oc3ccccc3c(=O)c2c1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20120214803A1,Nc1cc(Cl)c(F)cc1[N+](=O)[O-].O=N[O-].O=S(Cl)Cl>>O=[N+]([O-])c1cc(F)c(Cl)cc1S(=O)(=O)Cl,Cl[Cu],O,,Cl,,val
US20100305052A1,CC(=O)C1=C(C)Nc2cc[nH]c(=O)c2C1c1ccc(C#N)cc1OC(F)(F)F.CCOS(=O)(=O)C(F)(F)F>>CCOc1nccc2c1C(c1ccc(C#N)cc1OC(F)(F)F)C(C(C)=O)=C(C)N2,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20070032475A1,Clc1cccc2[nH]c(C3CCCNC3)nc12.O=C=NCCC1CCN(c2ccncc2)CC1>>O=C(NCCC1CCN(c2ccncc2)CC1)N1CCCC(c2nc3c(Cl)cccc3[nH]2)C1,,ClCCl,,CCN(CC)CC,Cl,val
US05478838,CC(=O)Cl.CC(=O)NC(C)(C)c1ccccc1>>CC(=O)NC(C)(C)c1ccc(C(C)=O)cc1,,CC(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04948796,Cc1ccc2c(c1)C(=O)c1cccnc1CC2>>Cc1ccc2c(c1)C(O)c1cccnc1CC2,,CCO,,O,[BH4-].[Na+],val
US20150266857A1,C1CNCCN1.O=S(=O)(c1ccccc1)n1cc(-c2ccc3nc(CCl)[nH]c3c2)c2ccc(F)cc21>>O=S(=O)(c1ccccc1)n1cc(-c2ccc3nc(CN4CCNCC4)[nH]c3c2)c2ccc(F)cc21,,CN(C)C=O,O,,,val
USRE028935,COCCBr.O=C1CC(=O)N(c2ccccc2)c2cc(Cl)ccc2N1>>COCCN1C(=O)CC(=O)N(c2ccccc2)c2cc(Cl)ccc21,,C1CCOC1,,[H-].[Na+],,val
US04758262,C=CC(c1ccc(Cl)cc1)C(C)C.O=C(OO)c1cccc(Cl)c1>>CC(C)C(c1ccc(Cl)cc1)C1CO1,,ClC(Cl)Cl,,,,val
US20090227580A1,CCN(CC1CCCC1)c1nc2c(Br)cn(C)c2cc1C#N.C[Mg]Br>>CCN(CC1CCCC1)c1nc2c(C)cn(C)c2cc1C#N,,C1CCOC1,,O,,val
US20070066614A1,CC(C#N)c1nsc(NC(=O)OC(C)(C)C)n1>>CC(CN)c1nsc(NC(=O)OC(C)(C)C)n1,[Ni],CO,,,,val
US20090291079A1,CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccc(N)cc3)nc(N3CC4CCC(C3)O4)n2)CC1.Nc1ccncc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc(N3CC4CCC(C3)O4)n2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20080051578A1,N#Cc1ccc(NC(=O)COCCCl)cc1>>N#Cc1ccc(N2CCOCC2=O)cc1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020094994A1,CCOC(=O)C1CN(C(C)=O)CC1c1ccc(NC(=O)Cc2ccc(NC(=O)Nc3ccccc3C)c(OC)c2)cc1>>COc1cc(CC(=O)Nc2ccc(C3CN(C(C)=O)CC3C(=O)O)cc2)ccc1NC(=O)Nc1ccccc1C,,CCO,,[Na+].[OH-],,val
US20120214794A1,COC(=O)CBr.O=C1NCC(c2ccc(Cl)cc2)c2cc(N3CCOCC3)sc21>>COC(=O)CN1CC(c2ccc(Cl)cc2)c2cc(N3CCOCC3)sc2C1=O,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20100113510A1,CCOC(=O)C(C)(O)c1cccs1.c1ccncc1>>CCOC(=O)C(C)(c1cccs1)N1CCCCC1,,CCOCC,Cl,O,O=S(Cl)Cl,val
US20130150343A1,C1CC2COCC1N2.C1CCOC1.C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCOS(C)(=O)=O)c4)c4ccccc43)cn12>>C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCN5C6CCC5COC6)c4)c4ccccc43)cn12.O=CO,,C1CCOC1,,,,val
US20150210682A1,CC(C)(CO)CBr.CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2C(C)C>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCC(C)(C)CO)cc1CC2C(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140005169A1,CC(=O)N/N=C1\Nc2sc(C)c(C)c2C(c2ccc(Cl)cc2)=NC1(C)C>>Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=NC(C)(C)c1nnc(C)n1-2,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090036492A1,COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.O=Cc1cccc2c1CCCC2>>COc1cc(O)c2c(c1C(=O)NCc1cccc3c1CCCC3)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,,CC#N,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20130231331A1,CC1(C)CCNCC1.COC(=O)Cc1c(C)nc2cc(Br)nn2c1Cl>>COC(=O)Cc1c(C)nc2cc(Br)nn2c1N1CCC(C)(C)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US06358971B1,O=C(c1ccccc1)c1ccc2nc(NC(=O)C(F)(F)F)c(-c3cccc4ccccc34)n2c1>>Nc1nc2ccc(C(=O)c3ccccc3)cn2c1-c1cccc2ccccc12,,CCOC(C)=O,,,,val
US20160184318A1,CC(C)(C)OC(=O)N1CCNCC1.Cc1nc(C=O)co1>>Cc1nc(CN2CCN(C(=O)OC(C)(C)C)CC2)co1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070232591A1,CCCC[Sn](CCCC)(CCCC)c1cccnn1.O=C(CN1CCc2nc(Br)sc2C1)N1CCN(C2CCC2)CC1>>O=C(CN1CCc2nc(-c3cccnn3)sc2C1)N1CCN(C2CCC2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20150051188A1,CC(C)(C)OC(=O)N1CCC(N)C1.O=C(NC[C@@H]1CO1)OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC(NC[C@H](O)CNC(=O)OCc2ccccc2)C1,,CC#N,,,,val
US20060270637A1,O=C1CCCC(=O)O1.O=C1O[C@@H](Cn2ccnn2)CN1c1ccc(-c2ccc(C3=NO[C@H](CO)C3)nc2)c(F)c1.c1ccncc1>>COC(=O)CCCC(=O)OC[C@@H]1CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cn2)=NO1,CN(C)c1ccncc1,CN(C)C=O,,,,val
US20070197512A1,CC(=O)OC(C)=O.COc1cc(CO)c2c(c1)NC(=O)C(C(C)C)O2>>COc1cc(COC(C)=O)c2c(c1)NC(=O)C(C(C)C)O2,,ClC(Cl)Cl,,O,c1ccncc1,val
US20030032663A1,CCCCN.CCN(CC)CCCOc1ccc([N+](=O)[O-])c(F)c1>>CCCCNc1cc(OCCCN(CC)CC)ccc1[N+](=O)[O-],,C1CCOC1,,,,val
US20150210682A1,COCCOc1cc(CC(N)C(C)C)ccc1F.O=CO>>COCCOc1cc(CC(NC=O)C(C)C)ccc1F,,C1COCCO1,O,,,val
US20060148805A1,CC(C)CNCC(C)C.COc1ccc2c(c1)nc(C(=O)C(C)(C)C)n2CC(=O)O>>COc1ccc2c(c1)nc(C(=O)C(C)(C)C)n2CC(=O)N(CC(C)C)CC(C)C,,CN(C)C=O,ClCCCl,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US20030225081A1,COc1cccc(C2CC(c3ccccn3)=NN(c3ccccc3Br)C2=O)c1>>O=C1C(c2cccc(O)c2)CC(c2ccccn2)=NN1c1ccccc1Br,,ClCCl,ClCCl,BrB(Br)Br,,val
US20080070935A1,Cc1c[nH]c2c1C(=O)CC(C)(C)C2.Cc1nc(N)nc2cc(F)ccc12>>Cc1cn(-c2ccc3c(C)nc(N)nc3c2)c2c1C(=O)CC(C)(C)C2,,CN(C)C=O,,[H-].[Na+],,val
US20070037064A1,CC[NH+](C)CC.COCCl>>CC[N+](C)(CC)COC.[Cl-],,Cc1ccccc1,,,,val
US20080058335A1,CC(C)(C)OC(=O)Nc1nc(CCOC2CCCCO2)c(C(C)(C)O)s1>>CC1(C)OCCc2nc(N)sc21,,C1CCOC1,,Cl,[Na+].[OH-],val
US20030092720A1,COC(=O)c1cnc2cc(CCc3nc(C(C)C)cs3)ccn2c1=O.N>>CC(C)c1csc(CCc2ccn3c(=O)c(C(N)=O)cnc3c2)n1,,CO,,,,val
US06057329,CC(=O)OC(C)=O.NCCNc1ccc([N+](=O)[O-])cn1>>CC(=O)NCCNc1ccc([N+](=O)[O-])cn1,,ClC(Cl)(Cl)Cl,,CO,,val
US20110217311A1,O=[N+]([O-])c1ccc(F)cc1OC1CCC2(CC1)OCCO2>>Nc1ccc(F)cc1OC1CCC2(CC1)OCCO2,[Pd],CO,,O=C[O-].[NH4+],,val
US04937268,OCCCl.SCCc1ccccn1>>OCCSCCc1ccccn1,,CO,,Cl,[K+].[OH-],val
US06320051B1,BrCCc1ccccc1.O=Cc1cc(Cl)cc(Cl)c1O>>O=Cc1cc(Cl)cc(Cl)c1OCCc1ccccc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090069299A1,CC(C)(C)n1cc2c(n1)c(=O)[nH]c1ccccc12.CCI>>CCc1c2c(nn1C(C)(C)C)c(=O)[nH]c1ccccc12,,C1CCOC1,CCOC(C)=O,CN(C)CCN(C)C,[Li]CCCC,val
US20070265348A1,O=[N+]([O-])c1ccc2cccc3c2c1CC3>>Nc1ccc2c3c(cccc13)CC2,[Pd],,,CCOC(C)=O,,val
US20080146562A1,O=[N+]([O-])c1ccc(C=Cc2nc(Cl)c3cc(N4CCOCC4)c(F)cc3n2)o1.O[C@@H]1CNC[C@H]1O>>O=[N+]([O-])c1ccc(/C=C/c2nc(N3C[C@@H](O)[C@H](O)C3)c3cc(N4CCOCC4)c(F)cc3n2)o1,,CN(C)C=O,,,,val
US20040242609A1,BrC(Br)c1cccc2nonc12.O>>O=Cc1ccc2nonc2c1,,O,,CCO,,val
US20150336986A1,Cn1c(=O)c2c(-c3cccc(F)c3)n(CC3COC(C)(C)O3)cc2n(C)c1=O>>Cn1c(=O)c2c(-c3cccc(F)c3)n(CC(O)CO)cc2n(C)c1=O,,CC#N,,Cl,O,val
US20080039444A1,CS(=O)(=O)Cl.OCCCCCc1ccc(OCCCN2CCCCCC2)cc1>>CS(=O)(=O)OCCCCCc1ccc(OCCCN2CCCCCC2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020049194A1,CN(C)C(=O)Cl.COc1cc(C(=O)N2CCCCc3cc(Cl)ccc32)ccc1N>>COc1cc(C(=O)N2CCCCc3cc(Cl)ccc32)ccc1NC(=O)N(C)C,,c1ccncc1,,Cl,,val
US20080119442A1,CC(C)(C)OC(=O)Nc1ccc2ccc(S(=O)(=O)N(Cc3ccccc3)Cc3ccccc3)cc2c1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)Nc1ccc2ccc(S(=O)(=O)N(Cc3ccccc3)Cc3ccccc3)cc2c1Br,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120046268A1,CCc1ccccc1C(=O)NC1CNCC(c2ccc(C(F)(F)F)cc2)C1.O=C=NCC1CCCO1>>O=C(NC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)NCC2CCCO2)C1)c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20080039511A1,CCOc1ccc(-c2nc(CCl)cs2)cc1OCC.C[N+]1([O-])CCOCC1>>CCOc1ccc(-c2nc(C=O)cs2)cc1OCC,,CC#N,,,,val
US20140336224A1,C=CC#N.O=C(Cc1ccc(Cl)cc1F)c1cccc(I)c1F>>N#CCCC(C(=O)c1cccc(I)c1F)c1ccc(Cl)cc1F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20150166564A1,CC(C)(C)OC(=O)N[C@@H]1CNC[C@H]1c1ccccc1.N#CCBr>>CC(C)(C)OC(=O)N[C@@H]1CN(CC#N)C[C@H]1c1ccccc1,,C1CCOC1,,,,val
US20070195309A1,CC1=Nc2cc(CO)ccc2C1(C)C.O=C1CCC(=O)N1Br>>CC1=Nc2cc(CBr)ccc2C1(C)C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050272764A1,COc1nc([N+](=O)[O-])c(NC(C)=O)cc1C>>COc1ncccc1C,,CO,,O,[Na+].[OH-],val
US20100168094A1,CI.COc1ccc(CN2CC(C(=O)O)Oc3ccc(OC(F)(F)F)cc32)cc1>>COc1ccc(CN2CC(C)(C(=O)O)Oc3ccc(OC(F)(F)F)cc32)cc1,,C1CCOC1,O,Cl,CC(C)[N-]C(C)C.[Li+],val
US20150038528A1,CCOC(=O)c1nc(I)c2cc(Oc3cc(F)ccc3Cl)ccc2c1O.N#C[Cu]>>CCOC(=O)c1nc(C#N)c2cc(Oc3cc(F)ccc3Cl)ccc2c1O,,CN1CCCC1=O,ClCCl,,,val
US05776963,COc1cc(C(C)=O)ccc1O.ClC/C=C\CCl>>COc1cccc(C(C)=O)c1OC/C=C\CCl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090008606A1,Brc1ccc2cc(Br)ccc2c1.OB(O)c1ccccc1>>Brc1ccc2cc(-c3ccccc3)ccc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20040198751A1,CSc1ncc2c(=O)[nH]n(C)c2n1.O=P(Br)(Br)Br>>CSc1ncc2c(Br)nn(C)c2n1,,CC#N,,O,,val
US20130130997A1,Fc1ccc(-c2cccs2)cc1.O=C(Cl)c1cc(Br)ccc1Cl>>O=C(c1ccc(-c2ccc(F)cc2)s1)c1cc(Br)ccc1Cl,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130165422A1,CC(C)(C)OC(=O)N1CCC(O)CC1.N#Cc1cccc(-c2cccc(O)c2)c1>>CC(C)(C)OC(=O)N1CCC(Oc2cccc(-c3cccc(C#N)c3)c2)CC1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090281103A1,CC(C)(C)[Si](C)(C)OCCCc1ccc(CC(C#N)C(=O)N(Cc2cccc(Cl)c2Cl)C2CC2)cc1.CI>>CC(C#N)(Cc1ccc(CCCO[Si](C)(C)C(C)(C)C)cc1)C(=O)N(Cc1cccc(Cl)c1Cl)C1CC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20160122331A1,COC(=O)c1ccc([C@H]2C[C@@H](N)CCO2)c(C)c1.O=C(O)C1(c2ccc3c(c2)OC(F)(F)O3)CC1>>COC(=O)c1ccc([C@H]2C[C@@H](NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)CCO2)c(C)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.F[P-](F)(F)(F)(F)F,val
US05683623,CCCCCCCCC(O)c1cccc(F)c1F>>CCCCCCCCCc1cccc(F)c1F,[Pd],,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US05198450,C1=CCNCC1.O=C(O)CCCc1ccccc1>>O=C(CCCc1ccccc1)N1CC=CCC1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20110076291A1,CSC(=N)NC(=O)OC(C)(C)C.O=C(O)c1cc2c(s1)-c1ccc(Br)cc1OCC2>>CSC(=NC(=O)c1cc2c(s1)-c1ccc(Br)cc1OCC2)NC(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US20040010037A1,C[C@H]1CN(Cc2ccccc2)[C@H](C)CN1c1ccc(C#N)c(C(F)(F)F)c1>>C[C@H]1CN[C@H](C)CN1c1ccc(C#N)c(C(F)(F)F)c1,,CC(Cl)Cl,,CC(Cl)OC(=O)Cl,,val
US20090220992A1,Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCCNC(=O)OC(C)(C)C>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCCN,,C1COCCO1,CO,Cl,,val
US20140336388A1,O=c1oc(C2CCN(c3ccc(/N=C/c4ccc([N+](=O)[O-])o4)cc3)CC2)nn1Cc1ccccc1>>O=c1oc(C2CCN(c3ccc(NCc4ccc([N+](=O)[O-])o4)cc3)CC2)nn1Cc1ccccc1,CC(=O)O,CO,,[BH3-]C#N.[Na+],,val
US20150158815A1,COc1ccc(F)c(B(O)O)c1.NC(=O)C(Nc1cncc(Br)c1)c1ccccc1>>COc1ccc(F)c(-c2cncc(NC(C(N)=O)c3ccccc3)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20080096955A1,CC(C)CNC(=O)C1C=C(c2ccc(CN3CCCC3)c(F)c2)C1>>CC(C)CNC(=O)C1CC(c2ccc(CN3CCCC3)c(F)c2)C1,[Pd],CCO,CCOC(C)=O,[H][H],,val
US05763450,C#C[Si](C)(C)C.COc1cc(Cc2cnc(N)nc2N)cc(I)c1OC>>C#CC(c1cc(OC)c(OC)c([Si](C)(C)C)c1)c1cnc(N)nc1N,[Cu]I,CN(C)C=O,,CCN(CC)CC,O,val
US20080153812A1,CCOC(=O)c1ccc(N2CCNCC2)cc1.COc1cccc(CCc2cc(N)n(C(C)(C)C)n2)c1>>COc1cccc(CCc2cc(NC(=O)c3ccc(N4CCNCC4)cc3)n(C(C)(C)C)n2)c1,,Cc1ccccc1,,C[Al](C)C,,val
US05801170,COc1ccc(N)cc1OCCNC(=O)OC(C)(C)C.Cc1nc(-c2ccc(-c3ccc(C(=O)O)cc3)c(C)c2)no1>>COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1OCCN,,CO,,Cl,,val
US04957928,CCOC(=O)C1CCCNC1.Cc1ccc(S(=O)(=O)OCCC2COc3ccccc3C2)cc1>>CCOC(=O)C1CCCN(CCC2COc3ccccc3C2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05521170,CO.O=C(O)c1ccccc1-c1ccccc1C(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1>>COC(=O)c1ccccc1-c1ccccc1C(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1,,CO,,CC(=O)Cl,,val
US04189485,CCNc1ncnc2nc[nH]c12.Fc1cccc(Cl)c1CCl>>CCNc1ncnc2c1ncn2Cc1c(F)cccc1Cl,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20110034440A1,CCI.Nc1cc2ccccc2cc1O>>COc1cc2ccccc2cc1N,,CN1CCCC1=O,,[Na+].[OH-],,val
US20050026925A1,C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3c(ncc(F)c3CO)N21>>C[C@@H]1CNC[C@H]2Cc3c(ncc(F)c3CO)N21,,C1COCCO1,,Cl,,val
US20130210811A1,O=C(O)c1cccc(Br)n1.c1cncc([C@@H]2CCCCN2)c1>>O=C(c1cccc(Br)n1)N1CCCCC1c1cccnc1,,CC#N,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060094767A1,Cl.Clc1ccc(C2=CCNCC2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(Cl)N1CC=C(c2ccc(Cl)cc2)CC1,,CCOCC,Cc1ccccc1,c1ccncc1,,val
US20100210636A1,O=C1Nc2ccc(-n3cccn3)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1>>O=C1Nc2ccc(-n3cccn3)cc2[C@](CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1,,CCO,,CCCCCC,,val
US05284849,O=C(OCc1ccccc1)C(Cc1ccccc1)CS(=O)(=O)Cl.O=C1CNCCN1>>O=C1CN(S(=O)(=O)CC(Cc2ccccc2)C(=O)OCc2ccccc2)CCN1,,ClCCl,c1ccncc1,,,val
US20120238539A1,CCOC(=O)c1c(C)cnn1-c1ccccc1OC>>COc1ccccc1-n1ncc(C)c1C(=O)O,,CO,,[Na+].[OH-],,val
US20050107360A1,Fc1cccc(COc2ccc3c(c2)CCNCC3)c1.NC(=O)CCl>>NC(=O)CN1CCc2ccc(OCc3cccc(F)c3)cc2CC1,,CC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20030130318A1,CC(C)NC(C)C.Cc1c(Cl)cccc1S(=O)(=O)Nc1ncc(CC(=O)O)s1>>Cc1c(Cl)cccc1S(=O)(=O)Nc1ncc(CC(=O)N(C(C)C)C(C)C)s1,CN(C)c1ccncc1,CN(C)C=O,ClCCl,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US20110098324A1,CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(Cc2ccccc2Cl)c1=O.Nc1ccccn1>>O=C(O)CNC(=O)c1c(O)c(C(=O)Nc2ccccn2)c(O)n(Cc2ccccc2Cl)c1=O,,ClC(Cl)Cl,,,,val
US05097023,COC1O[C@@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1>>CC1(O)O[C@@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1,,CCOC(C)=O,O,O=C(O)C(F)(F)F,,val
US05556864,COc1cccc(CCc2ccccc2O)c1.Cc1ccc(S(=O)(=O)OC[C@H]2CCCN2C(=O)OC(C)(C)C)cc1>>COc1cccc(CCc2ccccc2OC[C@H]2CCCN2C(=O)OC(C)(C)C)c1,,CC(=O)N(C)C,,CC(C)(C)[O-].[K+],,val
US09067948B2,O=P(Cl)(Cl)Cl.Oc1ccnc2sc3c(c12)CCC3>>Clc1ccnc2sc3c(c12)CCC3,,C1COCCO1,,,,val
US06562823B1,CS(=O)(=O)CC[C@H]1CN(c2cc(Cl)ccc2-c2cccc(OCc3ccccc3)c2)C(=O)CN1Cc1cncn1Cc1ccc(C#N)c(F)c1.O=C(O)C(F)(F)F>>CS(=O)(=O)CC[C@H]1CN(c2cc(Cl)ccc2-c2cccc(O)c2)C(=O)CN1Cc1cncn1Cc1ccc(C#N)c(F)c1.O=C(O)C(F)(F)F,[Pd],CCOC(C)=O,CO,Cl,[H][H],val
US20140011802A1,O=C(NC1=N[C@@]2(c3ccc(F)cc3F)CO[C@H](COC(c3ccccc3)(c3ccccc3)c3ccccc3)[C@H]2CS1)c1ccccc1>>O=C(NC1=N[C@@]2(c3ccc(F)cc3F)CO[C@H](CO)[C@H]2CS1)c1ccccc1,,O=CO,,O,O=C([O-])[O-].[K+].[K+],val
US04254282,CC(=O)CC(=O)O[C@H](C=C(C)C)C(Cl)(Cl)Cl.Cc1ccc(S(=O)(=O)N=[N+]=[N-])cc1>>CC=C(C)[C@@H](OC(=O)C=[N+]=[N-])C(Cl)(Cl)Cl,,CC#N,,CCN(CC)CC,[Na+].[OH-],val
US20130150341A1,CC(C)(C)OC(=O)N1CCN(c2ncnc3c2SCC3)CC1.Cl>>Cl.c1nc2c(c(N3CCNCC3)n1)SCC2,,C1COCCO1,,,,val
US20020037888A1,CCC1(c2cccc(O)c2)CCCCNC1=O.ClCCl.O=Cc1cccc(B(O)O)c1>>CCC1(c2cccc(Oc3cccc(C=O)c3)c2)CCCCN(C)C1=O,,ClCCl,,c1ccncc1,,val
US20140170067A1,BrCCCCCCCCCCCCCCCCBr.O>>OCCCCCCCCCCCCCCCCBr,,C1CCCCC1,,Br,,val
US20070293516A1,BrCc1ccccc1.Nc1ncnc2[nH]nc(-c3ccc4ccccc4c3)c12>>Nc1ncnc2c1c(-c1ccc3ccccc3c1)nn2Cc1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060167012A1,O=C(OCc1ccc([N+](=O)[O-])cc1)C1CCc2ccccc21.O=S(=O)(O)Cl>>O=C(OCc1ccc([N+](=O)[O-])cc1)C1CCc2ccc(S(=O)(=O)Cl)cc21,,ClC(Cl)Cl,,,,val
US20100273767A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)c1ccccc1Br>>CCOC(=O)c1ccccc1B1OC(C)(C)C(C)(C)O1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,CC(=O)[O-].[K+],,val
US20150175621A1,N#Cc1ccc(Br)cn1.O=S(O[Na])c1ccccc1>>N#Cc1ccc(S(=O)(=O)c2ccccc2)cn1,[Cu]I,CS(C)=O,,O,O,val
US20110190319A1,CCOC(=O)c1nc2cccc(C)n2c1Br.Cl>>Cc1cccc2nc(C(=O)O)c(Br)n12.Cl,,C1CCOC1,CCO,[Na+].[OH-],,val
US20040006079A1,ClCCl.O=C1c2ccccc2NC23OC12CN(Cc1ccccc1)C3c1ccc2c(c1)OCO2>>O=c1c2ccccc2[nH]c2c(-c3ccc4c(c3)CCO4)n(Cc3ccccc3)cc12,Cl,CN(C)C=O,,,,val
US20090124682A1,CC(C)(C)[Si](C)(C)OC[C@@H]1c2ccccc2C[C@@H]1O.CS(=O)(=O)Cl>>CC(C)(C)[Si](C)(C)OC[C@@H]1c2ccccc2C[C@@H]1OS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20080161346A1,COC(=O)c1cccc2c1CCN(Cc1ccncc1)C2.[Na+]>>O=C([O-])c1cccc2c1CCN(Cc1ccncc1)C2.[Na+],,C1COCCO1,,O,,val
US20160122327A1,Nc1cc(Br)ccc1Cl.O=N[O-]>>NNc1cc(Br)ccc1Cl,,Cl,O,Cl[Sn]Cl,,val
US20140323448A1,CCOC(OCC)OCC.O=C(O)CNC(=O)c1ccccc1>>CCO/C=C1\N=C(c2ccccc2)OC1=O,CN(C)c1ccncc1,,,CC(=O)OC(C)=O,,val
US20130053366A1,Cc1ccc2c(c1)c1c(n2CC(O)c2ccncc2)CCNC1.OCCBr>>Cc1ccc2c(c1)c1c(n2CC(O)c2ccncc2)CCN(CCO)C1,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20090062293A1,CC(C)(C)CCC(=O)N1CCN(c2cc(-c3noc(C(Cl)(Cl)Cl)n3)ccn2)CC1>>CC(C)(C)CCC(=O)N1CCN(c2cc(-c3ncon3)ccn2)CC1,,CO,,[BH4-].[Na+],,val
US05480857,CCI.CCOC(=O)c1c[nH]nc1C(F)(F)F>>CCOC(=O)c1cn(CC)nc1C(F)(F)F,,CC#N,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20150166512A1,Cc1ccc(Cl)cc1-c1c[nH]cc1C#N.Clc1ncnn2cccc12>>Cc1ccc(Cl)cc1-c1cn(-c2ncnn3cccc23)cc1C#N,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20070167594A1,C=C(C)C(=O)Cl.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>C=C(C)C(=O)OCC(O)C(O)C(O)C(O)CNC(=O)OC(C)(C)C,,C1COCCO1,,O,,val
US20050101604A1,Brc1cn2ccnc2c(Br)n1.Nc1ccc2cnoc2c1>>Brc1cn2ccnc2c(Nc2ccc3cnoc3c2)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150175561A1,C#CC[C@H](NC(=O)OC(C)(C)C)C(N)=O.CS(=O)(=O)O>>C#CC[C@H](NC(=O)OC(C)(C)C)C(=O)NS(C)(=O)=O,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCN=C=NCCCN(C)C,,val
US04596680,O=C(Oc1ccccc1)c1ccccc1Oc1ccc([N+](=O)[O-])cc1>>Nc1ccc(Oc2ccccc2C(=O)Oc2ccccc2)cc1,[Pd],CCO,,[H][H],,val
US20090012069A1,COC(=O)C1(C)OCC(Cc2ccc(OCCc3nc(-c4ccccc4)oc3C)cc2)CO1>>Cc1oc(-c2ccccc2)nc1CCOc1ccc(CC2COC(C)(C(=O)O)OC2)cc1,,CO,O,[Na+].[OH-],,val
US20150018547A1,COC(=O)Cc1csc2cc(O)cc(C)c12.ClCc1ccc(Cl)cc1Cl>>COC(=O)Cc1csc2cc(OCc3ccc(Cl)cc3Cl)cc(C)c12,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05296489,C=CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CC=CCC3)C(C)C(O)CC1=O)C(C)CC2OC>>CCCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCCCC3)C(C)C(O)CC1=O)C(C)CC2OC,[Pd],CO,,,,val
US20090252680A1,COc1ccc(N)nc1.O=C(CBr)c1ccc(Br)cc1>>Br.COc1ccc2nc(-c3ccc(Br)cc3)cn2c1,,CC#N,,,,val
US20120184544A1,CN(C)c1ccncc1.COCC(C)Oc1cc(Oc2ccc(-c3nnc(C)o3)cc2)cc(C(=O)O)c1.Nc1nnc(C2CC2)s1>>Cc1nnc(-c2ccc(Oc3cc(OC4CCN(C)C4=O)cc(C(=O)Nc4nnc(C5CC5)s4)c3)cc2)o1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20110224155A1,N#Cc1c(O)cccc1[N+](=O)[O-].O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>N#Cc1c(OS(=O)(=O)C(F)(F)F)cccc1[N+](=O)[O-],,ClCCl,,CCN(CC)CC,,val
US04742060,O=C=Nc1cccc(Cl)c1.O=[N+]([O-])N=C1NCCN1>>O=C(Nc1cccc(Cl)c1)N1CCNC1=N[N+](=O)[O-],,CC#N,,,,val
US20100167922A1,CCOC(OCC)(OCC)OCC.Cc1cccc(S(N)(=O)=O)c1C#N>>CCOC(=NS(=O)(=O)c1cccc(C)c1C#N)OCC,,CCO,,,,val
US20060100262A1,CN(C)CCN.COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(=O)COc1cc(F)ccc1-3>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(NCCN(C)C)COc1cc(F)ccc1-3,,CCOC(C)=O,ClCCCl,CC(=O)O,[Na+].[OH-],val
US06140100,N#Cc1cc(C[C@H](N)C(=O)O)ccc1O.O.O=C(O)C(F)(F)F>>N[C@@H](Cc1ccc(O)c(C(=O)O)c1)C(=O)O,,CC#N,,Cl,,val
US20100152190A1,CC(C)(C)C[C@@H]1N[C@@H](C(=O)O)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F.CCOC(=O)c1ccc(N)[nH]1>>CCOC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(c3ccc(Cl)cc3F)[C@H]2c2cccc(Cl)c2F)[nH]1,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04997836,CCI.COc1cc(C(=O)N2CCN(Cc3ccccc3)C(CO)C2)cc(OC)c1OC>>CCOCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1Cc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20160207926A1,CN(C(=O)OC(C)(C)C)[C@H]1CCN(C(=O)C2CC2)C1.O=C(O)C(F)(F)F>>CN[C@H]1CCN(C(=O)C2CC2)C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US06251910B1,CCCSc1nc(NC2CC2c2ccccc2)c2nnn(C3CC(CO)C4OC(C)(C)OC43)c2n1>>CCCSc1nc(NC2CC2c2ccccc2)c2nnn(C3CC(CO)C(O)C3O)c2n1,,CO,Cl,,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(CC(C)(C)C)c2ncnn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(CC(C)(C)C)c2ncnn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US04898862,CC1NC(=O)NN=C1c1ccc(O)c(Cl)c1.CCOC(=O)CCl>>CCOC(=O)COc1ccc(C2=NNC(=O)NC2C)cc1Cl,,CN(C)C=O,,[H-].[Na+],,val
US20120178765A1,CC(C)COc1cc(Br)cc(C(=O)Nc2nccs2)c1.Cc1ccc(/C=C/OB(O)O)cc1>>Cc1ccc(/C=C/c2cc(OCC(C)C)cc(C(=O)Nc3nccs3)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US04070368,CCOC(=O)Cc1c(C(=O)OCC)c(CC)cn1C.O=C(Cl)c1ccc(Cl)cc1>>CCOC(=O)Cc1c(C(=O)OCC)c(CC)c(C(=O)c2ccccc2Cl)n1C,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20040138228A1,Cc1ccc2ncccc2c1.O=[Se]>>O=Cc1ccc2ncccc2c1,,CCOC(C)=O,,,,val
US20080261919A1,CC(C)(C)OC(=O)CBr.CCC(=O)c1ccnc(OC)c1OC>>CCC(O)(CC(=O)OC(C)(C)C)c1ccnc(OC)c1OC,[Zn],C1CCOC1,CCOCC,C[Si](C)(C)Cl,,val
US20080070960A1,CN(C)C=O.COc1cc(OC)c(-c2noc3ccccc23)cc1Br>>COc1cc(OC)c(-c2noc3ccccc23)cc1C=O,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20110039847A1,CN(C)CCN.Cc1cnc(-c2ccccc2NC(=O)c2cc(Cl)nc(-c3ccccc3)n2)o1>>Cc1cnc(-c2ccccc2NC(=O)c2cc(NCCN(C)C)nc(-c3ccccc3)n2)o1,,C1CCOC1,O,,,val
US20130295141A1,COC(=O)/C=C/c1ccc(-c2cc(F)cc(F)c2)cc1>>COC(=O)CCc1ccc(-c2cc(F)cc(F)c2)cc1,[Pd],CCOC(C)=O,,,,val
US20090312338A1,Cc1ccc(S(=O)(=O)n2ccc3c2ncc2nnc([C@@H]4CC[C@H](NC(=O)OC(C)(C)C)C4)n23)cc1.Cl>>Cc1ccc(S(=O)(=O)n2ccc3c2ncc2nnc([C@@H]4CC[C@H](N)C4)n23)cc1.Cl,,C1COCCO1,,,,val
US20130245042A1,CC(C)(O)C(C)(C)O.O=C(NC/C=C/B(O)O)OCc1ccccc1>>CC1(C)OB(/C=C/CNC(=O)OCc2ccccc2)OC1(C)C,,CCOCC,,O=S(=O)([O-])[O-].[Mg+2],,val
US20120035214A1,C[C@H]1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)CN1C(=O)OC(C)(C)C.NNC(=NC1CC1)c1cccc(Cl)c1Cl>>C[C@H]1C[C@H](c2ccc(F)c(F)c2)[C@@H](c2nnc(-c3cccc(Cl)c3Cl)n2C2CC2)CN1C(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050267093A1,C#CC(=O)Nc1ccc(-c2ccc(Cl)cc2)cc1.CC(C)(C)OC(=O)NC1(c2ccc(I)cc2)CC1>>CC(C)(C)OC(=O)NC1(c2ccc(C#CC(=O)Nc3ccc(-c4ccc(Cl)cc4)cc3)cc2)CC1,[Cu]I,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130210795A1,CS(=O)(=O)Cl.Nc1cccc(C=O)c1>>CS(=O)(=O)Nc1cccc(C=O)c1,,ClCCl,,CCOC(C)=O,c1ccncc1,val
US06031015,CCCCCCOc1cc(C(=O)OCC)c(OCCCCCC)cc1C(=O)OCC>>CCCCCCOc1cc(C(=O)O)c(OCCCCCC)cc1C(=O)O,,CCO,,O,[K+].[OH-],val
US20160251380A1,CC1(C)OC[C@H](COc2ccc(F)c([C@H](O)C[N+](=O)[O-])c2)O1>>CC1(C)OC[C@H](COc2ccc(F)c([C@H](O)CN)c2)O1,[Pd],CO,,,,val
US20120245178A1,CC(=O)OC(C)=O.CC(C)CON=O.COC(=O)c1cc(N)c(C)s1>>COC(=O)c1cc2c(cnn2C(C)=O)s1,,Cc1ccccc1,O,CC(=O)[O-].[K+],,val
US20110059957A1,CC(=O)N1CCN(c2ccc(CCc3ccc(CN)cc3)nc2)CC1.CC(C)(C)OC(=O)NN.O=C(n1ccnc1)n1ccnc1>>CC(=O)N1CCN(c2ccc(CCc3ccc(CNC(=O)NNC(=O)OC(C)(C)C)cc3)nc2)CC1,,C1CCOC1,,,,val
US20050148609A1,COc1ccc(C(=O)N(C)OC)cc1.Clc1cccc(-c2onc3ccc(Br)cc23)c1>>COc1ccc(C(=O)c2ccc3noc(-c4cccc(Cl)c4)c3c2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20150183791A1,CCCC#Cc1ccc2ncc(-c3ccc(C(C)=O)s3)n2n1>>CCCCCc1ccc2ncc(-c3ccc(C(C)=O)s3)n2n1,[Pd],CCO,,,,val
US20080153799A1,CCOc1cc2ncc(C(N)=O)c(Nc3ccccc3CC)c2cc1OCC>>CCOc1cc2ncc(C(N)O)c(Nc3ccccc3CC)c2cc1OCC,,C1CCOC1,,,,val
US20100099688A1,COS(=O)(=O)OC.COc1ccc(C(=O)O)c2c1OC1(CCOCC1)O2>>COC(=O)c1ccc(OC)c2c1OC1(CCOCC1)O2,,CC(C)=O,,,,val
US20160090381A1,CC(C)[C@@H]1COC(=O)N1C(=O)[C@H](C)C12CC(C1)C2.[Li]O>>C[C@@H](C(=O)O)C12CC(C1)C2,,C1CCOC1,O,OO,,val
US04304944,CCC=C1CCCC1=O.COC(=O)CC(C)=O>>CCC1CC(=O)C=C2CCCC21,,CO,,[Na],,val
US20080269196A1,N#Cc1ccc(C=O)cc1.NCC(F)(F)F>>N#Cc1ccc(CNCC(F)(F)F)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20050101595A1,Nc1nc(NC2CCNCC2)sc1C(=O)c1c(F)cccc1F.O=S(=O)(Cl)CCCCl>>Nc1nc(NC2CCN(S(=O)(=O)CCCCl)CC2)sc1C(=O)c1c(F)cccc1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20060281810A1,COC(=O)c1ccccc1N.Cc1cc(C(=O)Cl)ccc1Br>>COC(=O)c1ccccc1NC(=O)c1ccc(Br)c(C)c1,,ClCCl,,CCN(CC)CC,,val
US06207660B1,O=C1NC(=O)c2c(CCBr)cccc21.OCCOCCOCCNCc1ccccc1>>O=C1NC(=O)C2(CCN(CCOCCOCCO)Cc3ccccc3)C=CC=CC12,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050256158A1,COc1c(F)cc(C(=O)N2c3ccccc3[C@H](N(C(C)=O)c3ccc(Cl)cc3)C[C@@H]2C)cc1F>>CC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2cc(F)c(O)c(F)c2)c2ccccc21,,ClCCl,,BrB(Br)Br,,val
US20090099205A1,CC(=O)OCC(=O)Cl.Cc1cc(Cl)nc(Cl)c1C(=O)NCC[C@@H](C)N1CCC(NCc2ccsc2)CC1>>Cc1cc(Cl)nc(Cl)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CO)CC1,,ClCCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20150297587A1,COc1cc(B(O)O)cc(OC)c1OC.Cc1ccc(S(=O)(=O)n2cc(-c3ccc(CN4CCN(C)CC4)cc3)c3cc(Br)cnc32)cc1>>CNC(=O)c1ccc(-c2c[nH]c3ncc(-c4cc(OC)c(OC)c(OC)c4)cc23)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,,O,O=C([O-])[O-].[Na+].[Na+],val
US05051508,Cc1ccccc1N.Cc1nc2c(C)cccc2c(Cl)c1CCCl>>Cc1ccccc1N1CCc2c(C)nc3c(C)cccc3c21,,CCCCO,,Cl,,val
US20090018132A1,BrC(Br)(Br)Br.C[Si](C)(C)CCOCn1nnc2c(CO)cc(C(F)(F)F)cc21>>C[Si](C)(C)CCOCn1nnc2c(CBr)cc(C(F)(F)F)cc21,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06218431B1,CCCC=Cc1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccccc1F>>CCCCCc1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccccc1F,,CCCCCC,CCOC(C)=O,,,val
US09266853B2,CC#CCOc1ccc(C[C@H](N)C(=O)OC)cc1.CCC[C@@](O)(C(=O)OC(C)(C)C)[C@H](/C=C/CCCCCCC1(CCCCc2ccccc2)OCCO1)C(=O)N1C(=S)OC(c2ccccc2)(c2ccccc2)[C@@H]1C(C)C>>CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCC2(CCCCc3ccccc3)OCCO2)[C@@](O)(CCC)C(=O)OC(C)(C)C)C(=O)OC)cc1,,ClCCl,,,,val
US04374139,CC(=O)c1ccc2c(c1)[C@@]13CCCC[C@H]1[C@@H](C2)NCC3.ClCC1CCC1>>CC(=O)c1ccc2c(c1)[C@@]13CCCC[C@H]1[C@@H](C2)N(CC1CCC1)CC3,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040180911A1,COC(=O)[C@H]1C[C@@H](n2c(Br)c(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1.C[Sn](C)(C)C>>COC(=O)[C@@H]1C[C@H](n2c(C)c(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1,,CN(C)C=O,,,,val
US20100267714A1,BrCc1ccccc1.O=c1[nH]c2ccc(OC3CCCCO3)cc2o1>>O=c1oc2cc(OC3CCCCO3)ccc2n1Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050203107A1,C1COCCN1.CCCSc1nc(Cl)c([N+](=O)[O-])c(Cl)n1>>CCCSc1nc(Cl)c([N+](=O)[O-])c(N2CCOCC2)n1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20110195977A1,COc1cc(/C=C/C(=O)Nc2cccc(Cl)c2)ccc1S(N)(=O)=O>>NS(=O)(=O)c1ccc(/C=C/C(=O)Nc2cccc(Cl)c2)cc1O,,ClCCl,,BrB(Br)Br,,val
US20060084645A1,CS(=O)(=O)c1ccc(Nc2cc(Cl)nc(-c3ccccc3)n2)cc1.OB(O)c1ccc(OC(F)(F)F)cc1>>CS(=O)(=O)c1ccc(Nc2cc(-c3ccc(OC(F)(F)F)cc3)nc(-c3ccccc3)n2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20080234260A1,CCOC(=O)c1cc2cc(O)ccc2o1.OCCN1CCC(F)(F)CC1>>CCOC(=O)c1cc2cc(OCCN3CCC(F)(F)CC3)ccc2o1,,ClCCl,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060173048A1,CCn1c(C(O)(c2cccc(F)c2)c2cccc(F)c2)nc(-c2ccncc2)c1-c1ccc(Cl)cc1>>CCn1c(C(c2cccc(F)c2)c2cccc(F)c2)nc(-c2ccncc2)c1-c1ccc(Cl)cc1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20100317663A1,CNC(=O)c1ccccc1N.Clc1cc(I)c(Br)cn1>>CNC(=O)c1ccccc1Nc1cc(Cl)ncc1Br,,CC(C)O,,Cl,,val
US03948918,Cc1cccc(N=C=O)c1.NN1CCN(CCc2c[nH]c3ccccc23)CC1>>Cc1cccc(NC(=O)NN2CCN(CCc3c[nH]c4ccccc34)CC2)c1,,CCOCC,,ClCCl,,val
US20080153837A1,CCN(CC)CC.Nc1cc(F)c(F)cc1N.O=C(Cl)C1=c2ccccc2=C2C(=O)C=CC=C12>>CC(C)OC(C)C.[NH-]c1cc(F)c(F)cc1N,,ClCCl,,,,val
US05426226,CCCN(CCC)C1CCc2cccc(C(=O)CC(=O)OC(C)(C)C)c2C1.NN>>CCCN(CCC)C1CCc2cccc(-c3cc(O)[nH]n3)c2C1,,CO,,,,val
US20100120806A1,CS(=O)(=O)O.Cc1nn(C)cc1-c1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1>>CS(=O)(=O)O.Cc1c(-c2cc(Oc3cc(F)c(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccn2)cnn1C,,C1CCOC1,CCOCC,CS(=O)(=O)O,,val
US20090143372A1,CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(CO)c4)cc23)CC1>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(C=O)c4)cc23)CC1,O=[Mn]=O,C1CCOC1,,,,val
US20050032846A1,Cc1cc(C)c(O)c(C)c1.Cc1nc(Cl)c(C)c(Cl)n1>>Cc1cc(C)c(Oc2nc(C)nc(Cl)c2C)c(C)c1,,C1CCOC1,,[H-].[Na+],,val
US20070155808A1,CCCc1csc(NCCc2ccccc2)n1.COC(=O)CCc1ccc(OCc2ccc(CCl)cc2)cc1>>CCCc1csc(N(CCc2ccccc2)Cc2ccc(COc3ccc(CCC(=O)OC)cc3)cc2)n1,,CN(C)C=O,,O,[H-].[Na+],val
US20100249149A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCOc1ccccc1-c1cc(N)ncn1>>CCOc1ccccc1-c1cc(NC(=O)C2CCN(C(=O)OC(C)(C)C)CC2)ncn1,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20120309738A1,CN(C)C(=O)C1CCCN1.Nc1cc(Cl)c(Cl)cc1[N+](=O)[O-]>>CN(C)C(=O)C1CCCN1c1cc(N)c([N+](=O)[O-])cc1Cl,,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20070249670A1,COC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1N)C1CCCCC1.COc1ccc(N=C=O)c(OC)c1>>COC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1ccc(OC)cc1OC)C1CCCCC1,,CN(C)C=O,,CCN(CC)CC,,val
US20080280876A1,CC(C)Oc1ccc(-c2noc(-c3ccc(CNCC4COC(C)(C)O4)cc3)n2)cc1Cl>>CC(C)Oc1ccc(-c2noc(-c3ccc(CNCC(O)CO)cc3)n2)cc1Cl,,C1CCOC1,,Cl,[Na+].[OH-],val
US20140056849A1,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F.O=C(Cl)c1ccccc1>>CCCS(=O)(=O)N(C(=O)c1ccccc1)c1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F,,C1COCCO1,,CCN(CC)CC,,val
US04794108,CC(C)(C)OC(=O)N[C@@H]1C(=O)N(OCc2ccccc2)[C@H]1C(N)=O>>CC(C)(C)OC(=O)N[C@@H]1C(=O)N(O)[C@H]1C(N)=O,[Pd],CO,,,,val
US05314815,COc1ccc(C(=O)CBr)cc1.O>>COc1ccc(C(=O)CO)cc1,,O,,CN1CCCC1=O,,val
US05650410,CCN.COc1ccc(-c2nc(CCl)nc3cc(OC)c(OC)cc23)cc1OC>>CCNCN1CN=C(c2ccc(OC)c(OC)c2)c2cc(OC)c(OC)cc21,,ClCCl,,CCO,,val
US20110065708A1,CC(=O)c1cnc2nnn(C(C)c3c(F)cc4ncccc4c3F)c2n1.NOCCO>>C/C(=N\OCCO)c1cnc2nnn(C(C)c3c(F)cc4ncccc4c3F)c2n1,,CO,,Cl,,val
US20140212360A1,COCCOCCn1c2ccccc2c2cc(Br)ccc21.O=S(=O)(c1ccccc1)N(F)S(=O)(=O)c1ccccc1>>COCCOCCn1c2ccccc2c2cc(F)ccc21,,C1CCOC1,,[Li]CCCC,,val
US20110136780A1,Cc1ccc(S(=O)(=O)n2cc(C(=O)O)c3c(CN[C@H](CC#N)C(=O)NC4CCCC4)c(Cl)cnc32)cc1>>Cc1ccc(S(=O)(=O)n2cc3c4c(c(Cl)cnc42)CN([C@H](CC#N)C(=O)NC2CCCC2)C3=O)cc1,,C1CCOC1,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080255115A1,O=C1CSC(=O)N1.O=Cc1ccc2nccc(-c3ccncc3)c2c1>>O=C1NC(=O)/C(=C/c2ccc3nccc(-c4ccncc4)c3c2)S1,,CCO,,C1CCNCC1,CC(=O)O,val
US20040077584A1,CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(C(=O)OC)nc32)[C@H](O)[C@@H]1O.NCCCN>>CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(C(=O)NCCCN)nc32)[C@H](O)[C@@H]1O,,ClCCl,,,,val
US20150038488A1,COc1ccc(-c2cn3nccc3c(=O)[nH]2)cc1OC.O=P(Cl)(Cl)Cl>>COc1ccc(-c2cn3nccc3c(Cl)n2)cc1OC,,O,,,,val
US20130184304A1,Clc1ccc2[nH]c3c(c2c1)C1CCCN1CC3.Fc1ccc(CCBr)cc1>>Fc1ccc(CCn2c3c(c4cc(Cl)ccc42)C2CCCN2CC3)cc1,,CCO,,CCN(CC)CC,CCOC(C)=O,val
US06156758,CC(C)(C)OC(=O)c1ccc(NC2CCNCC2)cc1.COc1cc2nc(Cl)nc(N)c2cc1OC>>COc1cc2nc(N3CCC(Nc4ccc(C(=O)OC(C)(C)C)cc4)CC3)nc(N)c2cc1OC,,CC(C)CCO,,,,val
US04092325,COC(=O)C(=O)OC.O=C1CCSc2sccc21>>COC(=O)C(=O)C1=C(O)c2ccsc2SC1,,c1ccccc1,,C[O-].[Na+],,val
US04349568,COc1ccc(Oc2ccc(S(C)(=O)=O)cc2)cc1>>CS(=O)(=O)c1ccc(Oc2ccc(O)cc2)cc1,,CC(=O)O,,Br,,val
US20160120841A1,CCON=C1CC(c2ccc(C(=O)OC)cn2)Oc2cc(OC)ccc21>>COC(=O)c1ccc(C2CC(N)c3ccc(OC)cc3O2)nc1,[Ni],CO,,,,val
US20090221555A1,COCCN1CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4OCC#N)n3)cc2CC1.O>>COCCN1CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4OCC(N)=O)n3)cc2CC1,,O,,[Na+].[OH-],,val
US20020147344A1,CCOCCBr.COC(=O)c1ccccc1OCCN1CCC(c2c[nH]c3ccccc23)CC1>>CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)OC)CC2)c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US05631286,CO.COC(OC)OC.COc1ccc(C2(C#N)CCC(=O)CC2)cc1OC1CCCC1>>COc1ccc(C2(C#N)CCC(OC)(OC)CC2)cc1OC1CCCC1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050203078A1,COC(=O)c1ccc(N2CCCS2(=O)=O)c(C)c1>>Cc1cc(C(=O)O)ccc1N1CCCS1(=O)=O,,CCO,,[Na+].[OH-],,val
US20140200197A1,CC(C)(C)OC(=O)Nc1c(F)ccc(F)c1I>>Nc1c(F)ccc(F)c1I,,C1CCOC1,C1COCCO1,Cl,,val
US20040019210A1,COc1cc(OC)c(F)c(N)c1F.CSc1ncc(C=O)c(NC2CC2)n1>>COc1cc(OC)c(F)c(N=Cc2cnc(SC)nc2NC2CC2)c1F,,Cc1ccccc1,,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US20030149001A1,CSc1ncc2cc(F)c(=O)n(C3CCCC3)c2n1.O=S(=O)(c1ccccc1)N1OC1c1ccccc1>>CS(=O)c1ncc2cc(F)c(=O)n(C3CCCC3)c2n1,,ClCCl,,,,val
US20070082912A1,CCOC(=O)c1cccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2)c1>>Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1cccc(C(=O)O)c1,,CCO,,[Na+].[OH-],,val
US04849513,O=C(O)CCCCCNC(=O)OCc1ccccc1.O=[N+]([O-])c1ccc(O)cc1>>O=C(CCCCCNC(=O)OCc1ccccc1)Oc1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,,,,val
US20120040020A1,C1CNCCN1.CC(C)(C)OC(=O)Nc1ncc(Br)nc1-c1nnc(-c2ccccc2)o1>>CC(C)(C)OC(=O)Nc1ncc(N2CCNCC2)nc1-c1nnc(-c2ccccc2)o1,,CN(C)C=O,,,,val
US20040171587A1,Nc1ccncc1.O=C(Cl)c1ccccc1>>NC(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20050032650A1,CCc1nc2ccc(SC)nn2c1S(N)(=O)=O.O.O=C(OO)c1cccc(Cl)c1>>CCc1nc2ccc(S(C)(=O)=O)nn2c1S(N)(=O)=O,,CN(C)C=O,,N,O,val
US05155117,CCOC(=O)c1ccccc1-c1ccc(C)cn1.O=C1CCC(=O)N1Br>>CCOC(=O)c1ccccc1-c1ccc(CBr)cn1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20110312936A1,CCC(NC(C)=O)C1CCC2(CC1)OCCO2>>CCC(NC(C)=O)C1CCC(=O)CC1,,CC#N,,Cl,,val
US20090221583A1,O=C(NCC(=O)N1CCN(C(=O)c2cc(F)ccc2C(F)(F)F)CC1)c1cc(-c2ccccc2OCc2ccccc2)[nH]n1>>O=C(NCC(=O)N1CCN(C(=O)c2cc(F)ccc2C(F)(F)F)CC1)c1cc(-c2ccccc2O)[nH]n1,[Pd],C1CCOC1,CO,,,val
US20050277674A1,CN(C)C1(c2ccccc2)CCC(CNC(=O)N2CC=C(c3c[nH]c4ccc(F)cc34)CC2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CN(C)C1(c2ccccc2)CCC(CNC(=O)N2CC=C(c3c[nH]c4ccc(F)cc34)CC2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O,,CCO,,,,val
US20100305133A1,CCOC(=O)CNC(=O)c1c(O)c(-c2ncccn2)cc2nccnc12>>O=C(O)CNC(=O)c1c(O)c(-c2ncccn2)cc2nccnc12,,CCO,,[Na+].[OH-],,val
US20100240638A1,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](OC(=O)N2Cc3cccc(F)c3C2)CN1C(=O)OC(C)(C)C)C(=O)NS(=O)(=O)c1ccccc1NCCOCCCOCC(=O)O>>C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](OC(=O)N2Cc3cccc(F)c3C2)CN1)C(=O)NS(=O)(=O)c1ccccc1NCCOCCCOCC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060160870A1,COC(=O)C(Cl)Cc1ccc(OCc2ccccc2)cc1.O=S1(=O)NC(=S)c2ccccc21>>COC(=O)C(Cc1ccc(OCc2ccccc2)cc1)SC1=NS(=O)(=O)c2ccccc21,,CO,,[Na+].[OH-],,val
US04001416,COS(=O)(=O)OC.O=C(c1cccnc1Cl)N(O)C1CCCCC1>>CON(C(=O)c1cccnc1Cl)C1CCCCC1,,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US04618610,CCC(=O)c1ccccc1O.ClCc1ccccc1>>CCC(=O)c1ccccc1OCc1ccccc1,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20020049204A1,C[Mg]Br.N#Cc1cc(-c2cccc(F)c2)ccc1N.N#Cc1cc(Br)ccc1N.OB(O)c1cccc(F)c1>>CC(=O)c1cc(-c2cccc(F)c2)ccc1N.N#Cc1cc(-c2cccc(F)c2)ccc1N,,C1CCOC1,CCOC(C)=O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20070191372A1,CCOC(=O)C(F)(F)F.COCCOc1ccc2nc(NCCCN(C)CCCN)n[n+]([O-])c2c1.O>>COCCOc1ccc2c(c1)[n+]([O-])nc(NCCCN(C)CCCNC(=O)C(F)(F)F)[n+]2[O-],,CC#N,,,,val
US20090076280A1,COc1ccc(OCCCN(Cc2cccc(O)c2)c2nc3ccccc3o2)cc1.O=C1OCC[C@@H]1O>>COc1ccc(OCCCN(Cc2cccc(O[C@@H]3CCOC3=O)c2)c2nc3ccccc3o2)cc1,,Cc1ccccc1,O,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130217686A1,C1CCNC1.CI.NCCc1ccccc1.O.O=C(n1ccnc1)n1ccnc1.OCC1CCC(O)CC1>>O=C(NCCc1ccccc1)OC1CCC(COC(=O)N2CCCC2)CC1,,CC#N,O,C1CCOC1,,val
US20060148811A1,Cl.Cl.Clc1ccc(CN2CCNCC2)cc1.O=C(CCl)c1ccccc1>>Cl.Cl.O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)c1ccccc1,,CCO,,CCN(CC)CC,,val
US20090042929A1,CNCc1cccs1.O=C(O)C12CC3CC(CC(O)(C3)C1)C2>>CN(Cc1cccs1)C(=O)C12CC3CC(CC(O)(C3)C1)C2,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US03953508,Cc1ccc(N)cc1O.Nc1ccc(O)cc1>>O=C1C=CC(=Nc2ccc(O)cc2)C=C1,,[Na+],[OH-],,,val
US20160030395A1,Fc1ccc([Mg]Br)cc1.O=C1Nc2ccc(Br)cc2C1=O>>O=C1Nc2ccc(Br)cc2C1(O)c1ccc(F)cc1,,C1CCOC1,CCOC(C)=O,,,val
US20040147561A1,CCOC(=O)c1cc(-c2csc(NC)n2)c(=O)[nH]c1C.O=S(=O)(Cl)c1ccccc1>>CCOC(=O)c1cc(-c2csc(N(C)S(=O)(=O)c3ccccc3)n2)c(=O)[nH]c1C,CN(C)c1ccncc1,c1ccncc1,,Cl,,val
US20100022529A1,CCOC(=O)c1c(C)cc(C)[nH]c1=O.OB(O)c1ccccc1>>CCOC(=O)c1c(C)cc(C)n(-c2ccccc2)c1=O,,C1COCCO1,,c1ccncc1,,val
US20100113462A1,ClCCl.O=C(O)C(F)(F)F.O=C(O)C1(C(=O)O)Cc2ccccc2C1>>CCOC(=O)C1(C(=O)O)Cc2ccccc2C1,,ClCCl,,,,val
US20140142119A1,COC(=O)c1coc(Cl)n1.Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(N[C@H]4CCC[C@@H](N)C4)n3)c3cc(F)cnc32)cc1>>COC(=O)c1coc(N[C@@H]2CCC[C@H](Nc3nc(-c4cn(S(=O)(=O)c5ccc(C)cc5)c5ncc(F)cc45)ncc3F)C2)n1,,CCOC(C)=O,CN(C)C=O,C1CCC2=NCCCN2CC1,O,val
US20110312933A1,CN(C(=O)OC(C)(C)C)[C@H]1CCN(C(=O)N[C@@H](CCc2ccccc2)C(=O)N2CCC(N3C(=O)C(C)(C)c4ccccc43)CC2)C1>>CN[C@H]1CCN(C(=O)N[C@@H](CCc2ccccc2)C(=O)N2CCC(N3C(=O)C(C)(C)c4ccccc43)CC2)C1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20070093521A1,CCOc1cc(C=O)cc(OCC)c1F.OCc1nccc2nc(NC3CCNCC3)oc12>>CCOc1cc(CN2CCC(Nc3nc4ccnc(CO)c4o3)CC2)cc(OCC)c1F,,CC(=O)O,CCO,CCN(C(C)C)C(C)C,[BH3-]C#N.[Na+],val
US06599890B1,COc1ccc(S(=O)(=O)N2CC[C@@H](C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)C[C@@H]2C(=O)NOCc2ccccc2)cc1>>COc1ccc(S(=O)(=O)N2CC[C@@H](C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)C[C@@H]2C(=O)NO)cc1,[Pd],CO,,[H][H],,val
US20070105904A1,C#Cc1ccc(N)nc1N.ON=C(Cl)Cc1ccc(Oc2ccccc2F)nc1>>Nc1ccc(-c2cc(Cc3ccc(Oc4ccccc4F)nc3)no2)c(N)n1,,O,,C1CCOC1,CCN(CC)CC,val
US20100273764A1,COc1ncc(Nc2ncc(C=C(C)C)cc2-c2nc(C)nc(N)n2)cc1F.O=C(OO)c1cccc(Cl)c1>>COc1ncc(Nc2ncc(C3OC3(C)C)cc2-c2nc(C)nc(N)n2)cc1F,,CCOC(C)=O,ClCCl,,,val
US20090137609A1,CCC(CC)(c1ccc(C#CC(O)(C(F)(F)F)C(F)(F)F)c(C)c1)c1ccc(-c2ccc(CC(=O)OC)c(F)c2)c(C)c1>>CCC(CC)(c1ccc(C#CC(O)(C(F)(F)F)C(F)(F)F)c(C)c1)c1ccc(-c2ccc(CC(=O)O)c(F)c2)c(C)c1,,CO,,[Na+].[OH-],[Cl-].[NH4+],val
US20070254892A1,CCOC(=O)c1cnc(SC)nc1Cl.NNc1ccccc1>>CSc1ncc2c(=O)[nH]n(-c3ccccc3)c2n1,,C1CCOC1,,CCN(CC)CC,,val
US20160096834A1,COC(=O)c1ccc(C(C)(C)C)cn1>>CC(C)(C)c1ccc(C(=O)O)nc1,,C1CCOC1,O,[Li+].[OH-],,val
US20090325952A1,CC(C)(C)OC(=O)c1ccc(N)cc1.O=C(Cl)CCCCCCCBr>>CC(C)(C)OC(=O)c1ccc(NC(=O)CCCCCCCBr)cc1,,ClCCl,,CCN(CC)CC,O,val
US20050075357A1,CI.Fc1cc(F)c(-c2c(Cl)nc3ncnn3c2NCC(F)(F)F)c(F)c1>>Cn1cnn2c(=NCC(F)(F)F)c(-c3c(F)cc(F)cc3F)c(Cl)nc12,,CCOC(C)=O,CS(C)=O,[H-].[Na+],,val
US20160200725A1,CC(C)(C)OC(=O)N1C[C@@H]2CN(CCO)C[C@@H]2C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1C[C@@H]2CN(CCOS(C)(=O)=O)C[C@@H]2C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20010027207A1,CCOC(=O)c1c(C)[nH]c(C=O)c1C.O=C1Cc2ccccc2N1>>CCOC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccccc32)c1C,C1CCNCC1,CCO,,,,val
US20060030554A1,CC(=O)c1ccc(N)cc1.O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>CC(=O)c1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1,,C1CCOC1,,CCOC(C)=O,c1ccncc1,val
US20100075953A1,ClCCCN1CCCCC1.Oc1ccc(I)cc1>>Ic1ccc(OCCCN2CCCCC2)cc1,,CN(C)C=O,,Cl,[I-].[K+],val
US20070249593A1,CSC(=NS(C)(=O)=O)SC.C[Si](C)(C)CCOCn1cc(C#N)nc1C(=O)Nc1ccc(C(CN)CN)cc1C1=CCCCC1>>C[Si](C)(C)CCOCn1cc(C#N)nc1C(=O)Nc1ccc(C2CNC(=NS(C)(=O)=O)NC2)cc1C1=CCCCC1,,ClCCCl,,,,val
US20130072467A1,COC(=O)[C@@H](CO)NC(=O)OCc1ccccc1.COC(C)(C)OC>>COC(=O)[C@H]1COC(C)(C)N1C(=O)OCc1ccccc1,,CC(C)=O,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20160075621A1,CC(C)CO.CCCCO>>CCCCC(CC)CO,,CC(C)CO,,,,val
US20140005146A1,C[C@@H](N)C(C)(C)C#N.NC(=O)c1cnn2cc(Br)cc2c1Cl>>C[C@@H](Nc1c(C(N)=O)cnn2cc(Br)cc12)C(C)(C)C#N,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US05266568,CC(C)(C)[Si](Oc1cccc(C(O)CCc2ccccc2C(=O)O)c1)(c1ccccc1)c1ccccc1.CI>>COC(=O)c1ccccc1CCC(O)c1cccc(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c1,,CC(C)=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20060229312A1,CS(=O)(=O)Nc1cccc(CCOS(C)(=O)=O)c1.Cc1ncc2c(N3CCNCC3)cccc2n1>>Cc1ncc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20070197558A1,CC(Oc1ccc(Cl)c([N+](=O)[O-])c1)c1ccc(Br)cc1.Oc1ccc(S)cc1>>CC(Oc1ccc(Sc2ccc(O)cc2)c([N+](=O)[O-])c1)c1ccc(Br)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120309769A1,C=CCOC(=O)c1ccc2c(c1)c(C)c(C)n2C(C)c1ccc(O[C@@H](C)C(=O)OC)cc1>>COC(=O)[C@H](C)Oc1ccc(C(C)n2c(C)c(C)c3cc(C(=O)O)ccc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,C1COCCN1,,val
US20110034433A1,CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(C)(=O)=O)NC(=O)N1c1cccc(C(F)(F)F)c1.CS(=O)(=O)Cl>>CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(C)(=O)=O)N(S(C)(=O)=O)C(=O)N1c1cccc(C(F)(F)F)c1,,C1CCOC1,,[H-].[Na+],,val
US20040102436A1,BrC(Br)(Br)Br.CC(C)(C)OC(=O)COCCCCO>>CC(C)(C)OC(=O)COCCCCBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120021907A1,CCc1ccc(O)cc1C1C(=O)C(C)(C)OC(C)(C)C1=O.O=[N+]([O-])c1ccc(F)cc1Cl>>CCc1ccc(Oc2ccc([N+](=O)[O-])c(Cl)c2)cc1C1C(=O)C(C)(C)OC(C)(C)C1=O,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100298295A1,Clc1ncc(Cl)c(Cl)n1.Nc1ccon1>>Clc1ncc(Cl)c(Nc2ccon2)n1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20090124596A1,C1COCCN1.COc1cccc(OS(=O)(=O)C(F)(F)F)c1C=O>>COc1cccc(OS(=O)(=O)C(F)(F)F)c1CN1CCOCC1,,ClCCl,,O=C(O)C(F)(F)F,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20020099055A1,CC(C)Cc1nn(C)c(=O)c2c[nH]cc12.COc1cc(CCl)cc(OC)c1OC>>COc1cc(Cn2cc3c(CC(C)C)nn(C)c(=O)c3c2)cc(OC)c1OC,,CN(C)C=O,Cl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110028509A1,Cl.N#Cc1ccc(CBr)cc1.NCc1ccc(F)cc1F>>Cl.N#Cc1ccc(CNCc2ccc(F)cc2F)cc1,,C1COCCO1,CC#N,O=C([O-])[O-].[K+].[K+],,val
US20080004442A1,II.O=C(O)c1cccc([N+](=O)[O-])c1>>O=C(O)c1cc(I)cc([N+](=O)[O-])c1,,O=S(=O)(O)O,,,,val
US20050148627A1,CC(C)CN.CCOC(=O)C1=Cc2cc(Cl)c(F)cc2OC1C(F)(F)F>>CCOC(=O)C1=Cc2cc(Cl)c(NCC(C)C)cc2OC1C(F)(F)F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100216814A1,CSc1cccc(C(C)=CBr)c1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>CSc1cccc(/C(C)=C/n2c3c(c4cc(C)ccc42)CN(C)CC3)c1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US05688803,Cl.O=c1[nH]nc2c3ccc([N+](=O)[O-])cc3[nH]c(=O)n12>>Cl.Nc1ccc2c(c1)[nH]c(=O)n1c(=O)[nH]nc21,,Cl,,Cl[Sn]Cl,,val
US20090069288A1,COc1ccc(-c2cc(N)on2)cc1.O=C(Cl)c1ccccc1C(F)(F)F>>COc1ccc(-c2cc(NC(=O)c3ccccc3C(F)(F)F)on2)cc1,,CC#N,,c1ccncc1,,val
US20070232626A1,CCOC(=O)CC(=O)[C@H]1OCO[C@H]1C=C(C)C.Cc1ccc(S(=O)(=O)N=[N+]=[N-])cc1>>CCOC(=O)C(=[N+]=[N-])C(=O)[C@H]1OCO[C@H]1C=C(C)C,,CC#N,,CCN(CC)CC,,val
US20110312945A1,C1COCCN1.O=S(=O)(Cl)c1ccccc1F>>O=S(=O)(c1ccccc1F)N1CCOCC1,,CC(C)=O,O,,,val
US20120115850A1,COc1cc(Cl)cc(C(C)Nc2cc(F)ccc2S(C)(=O)=O)c1OC.NC1CCNC1>>COc1cc(Cl)cc(C(C)Nc2cc(N3CC[C@@H](N)C3)ccc2S(C)(=O)=O)c1OC,,CC#N,,CCN(C(C)C)C(C)C,,val
US20050209225A1,CCOC(=O)C1CC1Br.c1ccc(COc2ccc3[nH]ccc3c2)cc1>>CCOC(=O)C1CC1c1cc2cc(OCc3ccccc3)ccc2[nH]1,,CN(C)C=O,,[H-].[Na+],,val
US20100087429A1,CC(C)(O)COc1ccc2c(c1Br)[C@]1(COC(N)=N1)c1cc(-c3cccnc3)ccc1O2.C[Sn](C)(C)C>>Cc1c(OCC(C)(C)O)ccc2c1[C@]1(COC(N)=N1)c1cc(-c3cccnc3)ccc1O2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,,,val
US20100210680A1,FC(F)(F)c1cccc2c1CO[C@H]1CNC[C@@H]21.O=C1CCC(=O)N1Br>>FC(F)(F)c1cc(Br)cc2c1CO[C@H]1CNC[C@@H]21,,O=S(=O)(O)O,,,,val
US20110076292A1,CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(O)cc1OCC2.NC(=O)[C@@H]1CCCN1>>CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(N3CCC[C@H]3C(N)=O)cc1OCC2,,ClCCl,,CO,,val
US20090163512A1,N#CCOc1ccc(Cl)cc1C1OCCO1>>N#CCOc1ccc(Cl)cc1C=O,,CCOC(C)=O,,O=C(O)C(F)(F)F,,val
US20160229814A1,COC(=O)c1cc([N+](=O)[O-])ccc1NCCC#N>>N#CCCNc1ccc([N+](=O)[O-])cc1C(=O)O,,O,,C1CCOC1,[Li+].[OH-],val
US20070249593A1,CC1(C)CC=C(c2cc(C3CC(=O)NC(=O)C3)ccc2NC(=O)c2nc(C#N)cn2COCC[Si](C)(C)C)CC1>>CC1(C)CC=C(c2cc(C3CC(=O)NC(=O)C3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1,,ClCCl,,CO,O=C(O)C(F)(F)F,val
US20070043081A1,Cc1cc(NC(=O)NCC(=O)O)ccn1.c1ccc(CC2CCNCC2)cc1>>Cc1cc(NC(=O)NCC(=O)N2CCC(Cc3ccccc3)CC2)ccn1,CN(C)c1ccncc1,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US20140248268A1,COc1cccc(C(=O)NC(=S)Nc2sc3c(c2C(=O)OC(C)(C)C)CC(C)(C)OC3)c1>>COc1cccc(C(=O)NC(=S)Nc2sc3c(c2C(=O)O)CC(C)(C)OC3)c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080312226A1,CC(=O)N(C)c1ccc(NC(=O)OCC(Cl)(Cl)Cl)cc1.c1ccc(-c2csc(N3CCNCC3)n2)cc1>>CC(=O)N(C)c1ccc(NC(=O)N2CCN(c3nc(-c4ccccc4)cs3)CC2)cc1,,O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20070004772A1,Cc1nc(C(F)(F)F)ccc1CCl.O=c1[nH]nc2c(-c3ccncc3)c(-c3ccc(Cl)cc3)ccn12>>Cc1nc(C(F)(F)F)ccc1Cn1nc2c(-c3ccncc3)c(-c3ccc(Cl)cc3)ccn2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130096161A1,CNOC.O=C(O)Cc1ccsc1>>CON(C)C(=O)Cc1ccsc1,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20120214785A1,COC(=O)c1ccc(OC(C)C)cn1>>CC(C)Oc1ccc(C=O)nc1,,Cc1ccccc1,,CC(C)C[AlH]CC(C)C,,val
US20070244131A1,COc1ccc(CCNc2cc(-c3ccc(C=O)s3)nc(OC)n2)cc1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>COc1ccc(CCNc2cc(-c3ccc(-c4cnco4)s3)nc(OC)n2)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20090023725A1,Cc1cc(C(=NNC(=O)OC(C)(C)C)c2ccc(Br)cc2F)n(C)n1>>Cc1cc(-c2n[nH]c3cc(Br)ccc23)n(C)n1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20140113931A1,Cc1cc(Nc2cc(N[C@H](CC(C)C)C(N)=O)cnc2C#N)sn1.OO>>Cc1cc(Nc2cc(N[C@H](CC(C)C)C(N)=O)cnc2C(N)=O)sn1,,CCO,CS(C)=O,CC(=O)O,[Na+].[OH-],val
US20110213109A1,COC1CCc2c(CBr)cccc21>>BrCc1cccc2c1CC=C2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060276464A1,CC(=O)c1ccc(S(=O)(=O)c2ccc(C)c(S(=O)(=O)NCCc3ccccn3)c2)cc1.C[Mg]Br>>Cc1ccc(S(=O)(=O)c2ccc(C(C)(C)O)cc2)cc1S(=O)(=O)NCCc1ccccn1,,C1CCOC1,,Cc1ccccc1,,val
US05866594,CC(=O)Cl.COC(=O)c1[nH]c2c(C)ccc(C)c2c1C=NO>>COC(=O)c1[nH]c2c(C)ccc(C)c2c1C=NOC(C)=O,,C1CCOC1,,CCN(CC)CC,,val
US04863920,CI.CN1Cc2c(C#CC(C)(C)O)ncn2-c2cccc(Cl)c2C1=O>>COC(C)(C)C#Cc1ncn2c1CN(C)C(=O)c1c(Cl)cccc1-2,,CS(C)=O,,O,[K+].[OH-],val
US04845110,COC(=O)c1cccc(C=CC(=O)O)c1>>COC(=O)c1cccc(CCC(=O)O)c1,[Pd],O,,O=C([O-])[O-].[Na+].[Na+],,val
US20030162795A1,O=C(Cl)C(=O)Cl.O=c1cc[nH]c2ccsc12>>Clc1ccnc2ccsc12,,ClCCl,,CN(C)C=O,,val
US20090264427A1,CCn1c(Sc2ccc(Nc3c(C#N)cnc4cc(F)c(OC)cc34)cc2Cl)nc(C)c1C.CN1CCN(CCCN)CC1>>CCn1c(Sc2ccc(Nc3c(C#N)cnc4cc(NCCCN5CCN(C)CC5)c(OC)cc34)cc2Cl)nc(C)c1C,,CN1CCCC1=O,,,,val
US20080171748A1,COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)[C@H](C[C@H](C)N)C[C@@H]3c3ccc(OC)cc3)cc21.Cc1ccc(S(=O)(=O)Cl)cc1.N#CBr>>COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)[C@H](C[C@H](C)N(C#N)S(=O)(=O)c4ccc(C)cc4)C[C@@H]3c3ccc(OC)cc3)cc21,,ClCCl,,CCN(CC)CC,,val
US20060025383A1,COc1cc(CO)cc(OC)c1OC.Clc1ncnc2[nH]cc(I)c12>>COc1cc(Cn2cc(I)c3c(Cl)ncnc32)cc(OC)c1OC,,C1CCOC1,O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070232627A1,CC(C)c1ccc2c(Cl)ncnc2c1.C[C@H](NC(=O)c1ccc(Sc2ccc(NC(=O)OC(C)(C)C)cc2)c(N)c1)c1ccccc1>>CC(C)c1ccc2c(Nc3cc(C(=O)N[C@@H](C)c4ccccc4)ccc3Sc3ccc(NC(=O)OC(C)(C)C)cc3)ncnc2c1,,CCO,,,,val
US20060264415A1,C1CCNCC1.O=Cc1cccc(OCCCN2C(=O)c3ccccc3C2=O)c1>>O=C1c2ccccc2C(=O)N1CCCOc1cccc(CN2CCCCC2)c1,[Pd],CCOC(C)=O,,,,val
US20050075342A1,CCOC(=O)CCCCI.COCC(=O)CC(=O)OC(C)(C)C>>CCOC(=O)CCCCC(C(=O)COC)C(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050101584A1,O=C1c2ccc(OCc3ccccc3)cc2C(=O)N1c1ccc(OCc2ccccc2)cc1>>c1ccc(COc2ccc(N3Cc4ccc(OCc5ccccc5)cc4C3)cc2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20070129334A1,COc1cc(Br)c(OC)c([N+](=O)[O-])c1>>COc1cc(N)c(OC)c(Br)c1,[Fe],O,,CC(=O)O,,val
US20080070903A1,CC1=C(C(=O)OCCC#N)C(c2cccc(Cl)c2)C(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)=C(C)N1>>CC1=C(C(=O)O)C(c2cccc(Cl)c2)C(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)=C(C)N1,,CO,,Cl,[Na+].[OH-],val
US20040043959A1,CSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](N=[N+]=[N-])[C@@H]1O[Si](C)(C)C(C)(C)C>>CSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](N=[N+]=[N-])[C@@H]1O,,CO,,N,,val
US06384041B1,CCc1c(C(=O)C(N)=O)c2c(OCC(=O)OC)nc(SC)nc2n1Cc1cccc(Cl)c1>>CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)nc(SC)nc2n1Cc1cccc(Cl)c1,,CO,,Cl,[Na+].[OH-],val
US20110009435A1,COc1cc(CNC(=O)c2nc3scc(COC[C@@H]4CC[C@@H](C(N)=O)CC4)c3c(=O)[nH]2)ccc1F>>COc1cc(CNC(=O)c2nc3scc(COC[C@@H]4CC[C@@H](C#N)CC4)c3c(=O)[nH]2)ccc1F,,CN(C)C=O,,O=P(Cl)(Cl)Cl,,val
US06335446B1,CCCCCCCCCC=O.Nc1ccc(Br)c(C(F)(F)F)c1>>CCCCCCCCCCNc1ccc(Br)c(C(F)(F)F)c1,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100311750A1,CC(C)(C)OC(=O)N1CC[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(Br)cn2)C1.Cn1ccc(B2OC(C)(C)C(C)(C)O2)n1>>Cn1cc(-c2cnc(N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]3CCN(C(=O)OC(C)(C)C)C3)nc2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])O.[Na+],val
US20090275567A1,CC(C)(C)OC(=O)N1CCCCC(N)C1.N=C(N)n1cccn1>>CC(C)(C)OC(=O)N1CCCCC(NC(=N)N)C1,,CC#N,,CCN(CC)CC,Cl,val
US20130053375A1,CC(C)(C)Sc1ccc2nccc(Cl)c2c1.O=S([O-])OO>>CC(C)(C)S(=O)(=O)c1ccc2nccc(Cl)c2c1,,CO,,O,,val
US20150119390A1,COc1nn2cc(-c3nc4c(O)cccc4o3)nc2s1.OCc1cccc(-c2ccoc2)c1>>COc1nn2cc(-c3nc4c(OCc5cccc(-c6ccoc6)c5)cccc4o3)nc2s1,,C1CCOC1,ClCCl,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110034440A1,CI.Cc1cc2c(I)n[nH]c2cc1[N+](=O)[O-]>>Cc1cc2c(I)nn(C)c2cc1[N+](=O)[O-],,CN(C)C=O,,Cl,[H-].[Na+],val
US20060094708A1,CC(C)Oc1ccc(C(=O)N[C@H](CCO)Cc2ccc(-c3cn4cccc(Br)c4n3)cc2)cc1C#N.Cc1noc(C)c1B(O)O>>Cc1noc(C)c1-c1cccn2cc(-c3ccc(C[C@@H](CCO)NC(=O)c4ccc(OC(C)C)c(C#N)c4)cc3)nc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100256143A1,COC(=O)c1cc(N2CCOCC2)nc(Cl)n1>>O=Cc1cc(N2CCOCC2)nc(Cl)n1,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US20150057271A1,Nc1cscn1.O=S(=O)(Cl)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1Br>>O=S(=O)(Nc1cscn1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1Br,,CCCCCCC,CCOC(C)=O,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20070037802A1,BrCc1ccccc1.Cc1ccc(S(=O)(=O)OCCOc2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)cc1>>Cc1ccc(S(=O)(=O)OCCOc2ccc3c(c2)c(S(=O)(=O)c2cccc4ccccc24)nn3Cc2ccccc2)cc1,,CC(C)=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05998436,CC(C)(C)Nc1nc(NCc2ccccc2)ncc1F>>CC(C)(C)Nc1nc(N)ncc1F,[Pd],CC(=O)O,,,,val
US04443443,O=C1c2ccccc2C(=O)N1CCCN1CCN(c2ccccc2)CC1>>NCCCN1CCN(c2ccccc2)CC1,,CCO,,NN,O,val
US20140128372A1,CCCC[C@H](CN=[N+]=[N-])NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12>>CCCC[C@H](CN)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090054609A1,CC(=O)c1cccc(C(C)=Nc2c(C)cc(C)cc2Cl)n1.CCc1cccc(CC)c1N>>CCc1cccc(CC)c1N=C(C)c1cccc(C(C)=Nc2c(C)cc(C)cc2Cl)n1,,C1CCOC1,,,,val
US20100305096A1,CC(C)(O)C(=O)O.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C3(O)CCNCC3)n(C)c2n1>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C3(O)CCN(C(=O)C(C)(C)O)CC3)n(C)c2n1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070179151A1,COc1cccc(B(O)O)c1.Cc1cc(Nc2cc3cc(O)ccc3c(Br)n2)n[nH]1>>COc1cccc(-c2nc(Nc3cc(C)[nH]n3)cc3cc(O)ccc23)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US06642418B1,COC(=O)C(C(=O)c1sc(C)c(OC)c1F)C(=O)C1CC1>>COc1c(C)sc(C(=O)CC(=O)C2CC2)c1F,Cl,CC#N,O,,,val
US05714489,COC(=O)C1(OC)CCC(OC)O1.Nc1cc2[nH]c(=O)c(=O)n(C3CCCCC3)c2cc1[N+](=O)[O-]>>COC(=O)c1cccn1-c1cc2[nH]c(=O)c(=O)n(C3CCCCC3)c2cc1[N+](=O)[O-],,CN(C)C=O,Cc1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150299189A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2c(-c3ccccc3)nccc2c1>>O=S(=O)(Oc1ccc2c(-c3ccccc3)nccc2c1)C(F)(F)F,,CCN(CC)CC,ClCCl,,,val
US20080194647A1,O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1cncc(F)c1>>O=S(=O)(Oc1cncc(F)c1)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20090253684A1,COC(=O)c1cc(OCc2ccccc2)cc(-c2cccc(F)c2)c1>>O=C(O)c1cc(OCc2ccccc2)cc(-c2cccc(F)c2)c1,,O,,Cl,[Li+].[OH-],val
US04153607,N#Cc1sc(N2CCCC2)nc1N.S>>NC(=S)c1sc(N2CCCC2)nc1N,,CCN(CC)CC,,CN(C)C=O,,val
US20060009471A1,CC(C)(C(=O)N1CCC(O)C1)c1ccc(Cl)cc1>>CC(C)(C(=O)N1CCC(=O)C1)c1ccc(Cl)cc1,,O,,CC(C)=O,,val
US04668640,Cn1c(=O)c2[nH]c(CCN)nc2n(C)c1=O.O=C(O)c1ccc2c(c1)C1(OC2=O)c2ccc(O)cc2Oc2cc(O)ccc21>>Cn1c(=O)c2[nH]c(CCN)nc2n(C)c1=O.O=C(O)c1ccc2c(c1)C1(OC2=O)c2ccc(O)cc2Oc2cc(O)ccc21,,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100152175A1,Cc1cc(F)ccc1-c1cc(Cl)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C1CCC2CNCCN12>>Cc1cc(F)ccc1-c1cc(N2CCN3C(=O)CCC3C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CS(C)=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20070123535A1,Br[Mg]c1ccccc1.COC(=O)C(=Cc1c[nH]c2cccnc12)C(=O)OC(C)(C)C>>COC(=O)C(C(=O)OC(C)(C)C)C(c1ccccc1)c1c[nH]c2cccnc12,,C1CCOC1,,,,val
US20050096336A1,CCOC(=O)/C=C/c1ccc(OCc2ccccc2)c2c1CCCC2>>CCOC(=O)CCc1ccc(O)c2c1CCCC2,[Pd],C1CCOC1,,,,val
US20130309188A1,Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(O)C2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H]1O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O.O=C=O>>O=c1[nH]cnc2nc[nH]c12.OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)[C@H](O)[C@@H]1O,,CCO,,,,val
US20120264737A1,CCOP(=S)([S-])OCC.COC(=O)c1cc(C#N)c(C)cc1C>>COC(=O)c1cc(C(N)=S)c(C)cc1C,,C1CCOC1,O,,,val
US20110224155A1,CC(=O)Cl.N#Cc1c(OC[C@@H]2CCC[NH2+]2)cccc1[N+](=O)[O-]>>CC(=O)N1CCC[C@H]1COc1cccc(N)c1C#N,,C1CCOC1,,CCN(CC)CC,,val
US20100197697A1,CON(C)C(=O)[C@@H]1CCN(Cc2ccccc2)C[C@@H]1c1ccc(Cl)cc1.C[Mg]Br>>CC(=O)[C@H]1CCN(Cc2ccccc2)C[C@@H]1c1ccc(Cl)cc1,,CO,,C[O-].[Na+],,val
US04096263,CCOC(CBr)OCC.Nc1nnnn1-c1ccccc1>>CCOC(CNc1nnnn1-c1ccccc1)OCC,,CN(C)C=O,,[H-].[Na+],,val
US20160207930A1,C[Al](C)C.FC(F)(F)c1cccc(Cl)n1>>Cc1cccc(C(F)(F)F)n1,,C1CCOC1,,,,val
US20070010670A1,O=C(Cl)c1cc(Cl)c(OCc2ccccc2)c(Cl)c1.c1ccc2c(c1)NCCN2>>O=C(c1cc(Cl)c(OCc2ccccc2)c(Cl)c1)N1CCNc2ccccc21,,CCOC(C)=O,,CCN(CC)CC,CO,val
US20160143895A1,CI.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccnc(-c4cc5c(F)cccc5[nH]4)c3)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cc[n+](C)c(-c4cc5c(F)cccc5[nH]4)c3)cc12.[I-],,CN(C)C=O,,,,val
US20120040942A1,CC(NC(=O)OC(C)(C)C)c1ccc(C(=O)C(F)(F)F)cc1.NO>>CC(NC(=O)OC(C)(C)C)c1ccc(C(=NO)C(F)(F)F)cc1,,CCO,c1ccncc1,,,val
US20060111412A1,CCOC(=O)Cn1nc(C(=O)OCC)cc1OCc1cc(F)cc(C(F)(F)F)c1>>CCOC(=O)c1cc(OCc2cc(F)cc(C(F)(F)F)c2)n(CC(=O)O)n1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US04757081,COc1cc(N)cc(OC)c1.COc1ccc(C(=O)C(C)C(=O)CC(=O)c2ccccc2)cc1.Cc1ccc(S(=O)(=O)O)cc1>>COc1ccc(-c2c(C)c(=O)cc(-c3ccccc3)n2-c2cc(OC)cc(OC)c2)cc1.Cc1ccc(S(=O)(=O)O)cc1,,Clc1ccccc1,,,,val
US20090082464A1,CC(C)(C)OC(=O)NCC(=O)O.CC(C)(CCO)CO[Si](C)(C)C(C)(C)C>>CC(C)(CCOC(=O)CNC(=O)OC(C)(C)C)CO[Si](C)(C)C(C)(C)C,CN(C)c1ccncc1,ClCCl,,,,val
US05496834,CCCC(CCC)C(=O)N[C@H](C(=O)N[C@H]1CCO[C@H]1OC(C)=O)C(C)C>>CCCC(CCC)C(=O)N[C@H](C(=O)N[C@H]1CCO[C@@H]1OC)C(C)C,Cl,CO,,,,val
US20110311458A1,CCOC(=O)c1ccc(C(=O)CBr)cc1.O=C(O[C@H]1CN2CCC1CC2)[C@H](Nc1ccccc1)c1ccccc1>>CCOC(=O)c1ccc(C(=O)C[N+]23CCC(CC2)[C@@H](OC(=O)[C@H](Nc2ccccc2)c2ccccc2)C3)cc1.[Br-],,CCOC(C)=O,,,,val
US20030032654A1,CC(=O)c1sc(NC(=O)Oc2ccccc2)nc1C.N[C@@H]1COCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1>>CC(=O)c1sc(NC(=O)N[C@@H]2COCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C,,CC#N,,,,val
US20050277660A1,CC(C)(CN)[C@H]1Nc2ccc(C#N)cc2[C@H]2CCC[C@H]21.O=C=Nc1ccc(Cl)c(Cl)c1>>CC(C)(CNC(=O)Nc1ccc(Cl)c(Cl)c1)[C@H]1Nc2ccc(C#N)cc2[C@H]2CCC[C@H]21,,CN(C)C=O,,CCOC(C)=O,O,val
US20060004013A1,C1COCCN1.O=C1CCc2cc(F)c(F)cc21>>O=C1CCc2cc(N3CCOCC3)c(F)cc21,,CN1CCCC1=O,,CCOC(C)=O,O,val
US20080182854A1,CC(C)(C)OC(=O)CCCCc1cccc(CO)n1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)CCCCc1cccc(COS(C)(=O)=O)n1,,O,,CCN(C(C)C)C(C)C,ClCCl,val
US20030108486A1,CCOC(=O)CCCBr.COC(=O)C(O)c1ccccc1>>CCOC(=O)CCCOc1ccc(CC(=O)OC)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090275570A1,CNC(=O)c1cnc(N[C@H]2CCCN(C(=O)OC(C)(C)C)C2)c2cc(-c3ccccc3)sc12>>CNC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccccc3)sc12,,C1COCCO1,,Cl,,val
US20130032785A1,Cc1cc(C)c2c(c1)C(=O)CCC2.Nc1cccc(Cl)c1CO>>Cc1cc(C)c2c(c1)-c1nc3cccc(Cl)c3cc1CC2,,Cc1ccccc1,,[K+].[OH-],,val
US20150183804A1,NCCO.O=C(CN1c2nc(N3C[C@@H]4C[C@H]3CO4)cc(=O)n2CC[C@H]1C(F)(F)F)c1ccc(Cl)nc1>>O=C(CN1c2nc(N3C[C@@H]4C[C@H]3CO4)cc(=O)n2CC[C@H]1C(F)(F)F)c1ccc(NCCO)nc1,,CCO,,,,val
US20050065151A1,COc1cnc(N2CCOCC2)c2sc(N)nc12.O=C(O)c1ccncc1>>COc1cnc(N2CCOCC2)c2sc(NC(=O)c3ccncc3)nc12,,C1CCOC1,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120316151A1,NNC(=O)C[C@@H]1CCN(C(=O)C2CC2)C1.Nc1cc(Cl)c(Br)cc1F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(C[C@@H]1CCN(C(=O)C2CC2)C1)NNC(=O)Nc1cc(Cl)c(Br)cc1F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060122237A1,CN[C@@H](C)C/C=C/c1cncc(OC)c1.O=C(O)c1cc(O)ccc1O>>CN[C@@H](C)C/C=C/c1cncc(OC)c1.O=C(O)c1cc(O)ccc1O,,CCO,,CCOC(C)=O,,val
US20160194350A1,CC(=O)OC(C)=O.CC[C@H](O)[C@@H]1C[C@H]2OC(C)(C)O[C@H]2O1>>CC[C@H](OC(C)=O)[C@@H]1C[C@H]2OC(C)(C)O[C@H]2O1,CN(C)c1ccncc1,ClCCl,,,,val
US20130317218A1,CCOC(=O)c1nc(Nc2ccc3c(OC)cccc3c2)sc1NC(=O)c1ccsc1.N>>COc1cccc2cc(Nc3nc(C(N)=O)c(NC(=O)c4ccsc4)s3)ccc12,,C1CCOC1,,CO,,val
US20090270374A1,C=CCI.O=c1cnc2ccc(F)cc2[nH]1>>C=CCn1c(=O)cnc2ccc(F)cc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080076745A1,CC(C)(C)OC(=O)NCCC[C@@H](CNC(=O)CC(CCNC(=O)OCc1ccccc1)N(C(=O)[O-])C(C)(C)C)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NCCC[C@@H](CNC(=O)CC(N)CCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C,[Pd],CCO,,,,val
US20150329549A1,COC(=O)CC(C)=O.[N-]=[N+]=Nc1ccc(Cl)cc1C1CC1>>Cc1c(C(=O)O)nnn1-c1ccc(Cl)cc1C1CC1,,CO,O,C[O-].[Na+],,val
US06159902,C=Cc1cccc(C(O)C(C)(C)N2COC(C)=C(c3ccccc3)C2=O)c1>>C=Cc1cccc(C(=O)C(C)(C)N2COC(C)=C(c3ccccc3)C2=O)c1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20060223801A1,CCc1cc(C#N)c(C(=O)O)[nH]1.C[Si](C)(C)C=[N+]=[N-]>>CCc1cc(C#N)c(C(=O)OC)[nH]1,,C1CCOC1,,CCOCC,,val
US04259162,C=C(C)C(=O)OCC1CO1.NC(N)=S>>C=C(C)C(=O)OCC1CS1,,CCO,O,,,val
US04983608,CCCN(C(=O)OCC)n1ccc2ccccc21>>CCCNn1ccc2ccccc21,,O,OCCO,[Na+].[OH-],,val
US20160168176A1,Nc1nc(Cl)ccc1C(=O)NCc1ccc(OCc2ccccc2)cc1.O=C1CCC(=O)N1Br>>Nc1nc(Cl)c(Br)cc1C(=O)NCc1ccc(OCc2ccccc2)cc1,,CC#N,,CN(C)C=O,,val
US20100069431A1,Nc1ncc(Br)cc1[N+](=O)[O-].OB(O)c1ccccc1>>Nc1ncc(-c2ccccc2)cc1[N+](=O)[O-],c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US04233231,CCCCC(C/C=C/[Sn](CCCC)(CCCC)CCCC)O[Si](CC)(CC)CC.II>>CCCCC(C/C=C/I)O[Si](CC)(CC)CC,,CCOCC,,,,val
US20060040957A1,COC(=O)Nc1cc(CBr)on1.Cc1c(=O)[nH]c(=O)n2cc(C(=O)NCc3ccc(F)cc3)sc12>>COC(=O)Nc1cc(Cn2c(=O)c(C)c3sc(C(=O)NCc4ccc(F)cc4)cn3c2=O)on1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060194969A1,CCOC(=O)c1cc(O[C@@H]2c3c(C)ccc(C)c3C[C@H]2O)c2nc(C)n(C)c2c1>>Cc1ccc(C)c2c1C[C@@H](O)[C@@H]2Oc1cc(C(=O)O)cc2c1nc(C)n2C,,C1COCCO1,,Cl,[Na+].[OH-],val
US20160185773A1,Cc1cnn(Cc2ccc(CN3CCOc4c(Cl)ncnc43)cc2)c1.NCc1ccc2c(N)nccc2c1>>Cc1cnn(Cc2ccc(CN3CCOc4c(NCc5ccc6c(N)nccc6c5)ncnc43)cc2)c1,,CCO,,,,val
US20050272779A1,CC(O)c1noc(-c2cccc(Cl)c2)n1.O=S(Cl)Cl>>CC(Cl)c1noc(-c2cccc(Cl)c2)n1,CN(C)C=O,,,,,val
US20080009490A1,C=CCN1CCN(C(=O)OC(C)(C)C)CC1=O>>C=CCN1CCNCC1=O,,CCOC(C)=O,,Cl,,val
US20100069381A1,FC(F)(F)c1cccc(CCl)c1.Sc1nnc(-c2ccc3ncsc3c2)o1>>FC(F)(F)c1cccc(CSc2nnc(-c3ccc4ncsc4c3)o2)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20100210619A1,CCOC(=O)CCCBr.O=[N+]([O-])c1ccc(S)cc1>>CCOC(=O)CCCSc1ccc([N+](=O)[O-])cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080045528A1,CNC(=O)c1cc(Oc2ccc3nc(S(C)=O)sc3c2)ccn1.NCC1CCCCC1>>CNC(=O)c1cc(Oc2ccc3nc(NCC4CCCCC4)sc3c2)ccn1,,CN(C)C=O,,,,val
US05521188,COc1cncnc1N1CCN(CCCc2cn([Si](C(C)C)(C(C)C)C(C)C)c3ccc(-c4c(NC(C)C)c(=O)c4=O)cc23)CC1>>COc1cncnc1N1CCN(CCCc2c[nH]c3ccc(-c4c(NC(C)C)c(=O)c4=O)cc23)CC1,,CC#N,,,,val
US20120149943A1,COC(C)(C)C.C[Si](C)(C)Cl.Fc1ccccc1F.[Li]CCCC>>CC[Si](CC)(CC)c1cccc(F)c1F,,O,,C1CCOC1,,val
US04503139,Cc1[nH]cnc1CO.O=S(Cl)Cl>>Cc1nc[nH]c1CCl.Cl,,CCOCC,,,,val
US20110015240A1,CC(=O)Nc1nc(CCc2ccc(CO)cc2F)cs1.CS(=O)(=O)Cl>>CC(=O)Nc1nc(CCc2ccc(CCl)cc2F)cs1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20100137281A1,CCc1cc(C(=O)OC)c(N)s1.NCCc1ccc(F)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCc1cc2c(=O)n(CCc3ccc(F)cc3)c(=O)[nH]c2s1,,ClCCl,,CCN(CC)CC,,val
US20040152719A1,CON(C)C(=O)c1cc(Cl)ccc1N.COc1ccc(CO)cc1>>COc1ccc(CNc2ccc(Cl)cc2C(=O)N(C)OC)cc1,,CC#N,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20030018034A1,CC(=O)NCc1ccc(CCl)cc1.COc1cc(N(C)C)nc(N2CCNCC2)n1>>COc1cc(N(C)C)nc(N2CCN(Cc3ccc(CNC(C)=O)cc3)CC2)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20030055093A1,CC(=O)OC(C)=O.O=C(NC1Cc2ccccc2C1)c1ccc(F)cc1>>CC(=O)c1ccc2c(c1)CC(NC(=O)c1ccc(F)cc1)C2,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20160022642A1,CC(CNC(=O)OC(C)(C)C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1>>CC(CN)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130090309A1,CS(N)(=O)=O.Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@@]3(O)CCCc4cc(C(=O)O)ccc43)s2)c1>>Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@@]3(O)CCCc4cc(C(=O)NS(C)(=O)=O)ccc43)s2)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090082311A1,CI.O=C(O)c1ccc(Br)cc1Cl>>COC(=O)c1ccc(Br)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05405989,C#CCO.O=C(Cl)CCCCCCc1ccccc1>>C#CCOC(=O)CCCCCCc1ccccc1,,Cc1ccccc1,,Cl,c1ccncc1,val
US04482552,Cn1nc(C=O)nc1NCCCOc1cccc(CN2CCCCC2)c1.c1ccoc1>>Cn1nc(C(O)c2ccco2)nc1NCCCOc1cccc(CN2CCCCC2)c1,,C1CCOC1,,O,[Li]CCCC,val
US20150252000A1,N#Cc1ccc2[nH]cc(C(=O)CCCCl)c2c1>>N#Cc1ccc2[nH]cc(CCCCCl)c2c1,,C1CCOC1,,O,[BH4-].[Na+],val
US05100893,CCC(=O)Cl.N=C(NO)c1cc(Cl)c(O)c(Cl)c1>>CCc1nc(-c2cc(Cl)c(O)c(Cl)c2)no1,,c1ccncc1,,,,val
US20160024009A1,COC(=O)[C@@H](N)CO.O=S(=O)(Cl)c1ccc(Cl)cc1>>COC(=O)[C@H](CO)NS(=O)(=O)c1ccc(Cl)cc1,,ClCCl,,Cl,,val
US20030045560A1,CNCc1ccc2cc(O)ccc2c1.O=C(Cl)c1cn(Cc2ccccc2)c2ccccc12>>CN(Cc1ccc2cc(O)ccc2c1)C(=O)c1cn(Cc2ccccc2)c2ccccc12,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20040192701A1,CC(C)(C)OC(=O)N1CCN(c2ccc(C=O)cc2)CC1.CCOC(=O)CP(=O)(OCC)OCC>>CCOC(=O)C=Cc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)cc1,,C1CCOC1,,[H-].[Na+],,val
US20160221990A1,CC1(C)OB(c2cccnc2)OC1(C)C.Clc1cc(Br)cc(Br)c1>>Clc1cc(Br)cc(-c2cccnc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20140179695A1,CCOC(=O)C1(COS(C)(=O)=O)CCC1.Oc1ccc(Br)cc1>>CCOC(=O)C1(COc2ccc(Br)cc2)CCC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030153557A1,CCOC(=O)CCc1ccc(C(=O)OC(C)(C)C)s1>>CCOC(=O)CCc1ccc(C(=O)O)s1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110130453A1,CCOC(=O)Cc1cccc(Oc2ccc(C(F)(F)F)cc2CO)c1.CS(=O)(=O)Cl>>CCOC(=O)Cc1cccc(Oc2ccc(C(F)(F)F)cc2COS(C)(=O)=O)c1,,ClCCl,,CCN(CC)CC,,val
US20110190342A1,CCCC(N)C(=O)O.O=C(O)c1cc2cc(Cl)ccc2nc1Cl>>CCCC(Nc1nc2ccc(Cl)cc2cc1C(=O)O)C(=O)O,,O,,CC#N,,val
US20070105852A1,COC(=O)c1sc(N=[N+]=[N-])c(C#N)c1-c1ccccc1C(C)(C)C>>COC(=O)c1sc(N)c(C#N)c1-c1ccc(C(C)(C)C)cc1,,C1CCOC1,,,,val
US06797710B2,CC(C)(C)OC(=O)N1CC[C@H]1C(=O)NCc1ccc2c(N)nccc2c1>>Nc1nccc2cc(CNC(=O)[C@@H]3CCN3)ccc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US07071201B2,CC#N.CCN(CC)CC.CN(C)C(=O)Cl.NCc1ccc2ccn(C3CCN(CCc4ccc(F)cc4)CC3)c2c1>>O=C1CCCN1Cc1ccc2ccn(C3CCN(CCc4ccc(F)cc4)CC3)c2c1,,CC#N,,,,val
US05972965,COc1cccc(C(O)C2CCCCCCC2=O)c1>>COc1cccc(CC2CCCCCCC2=O)c1,[Pd],CCO,,,,val
US04019892,CNC(=O)CO.Cc1cc(Cl)ccc1OCC=O>>Cc1cc(Cl)ccc1OCC1OCC(=O)N1C,,C1CCOC1,,CCOCC,FB(F)F,val
US20090312369A1,CCOC(=O)CO[C@@H](c1cccc(F)c1)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N1CCC[C@@H]([C@@H](OCCO)c2cccc(F)c2)C1,,CO,,[BH4-].[Na+],,val
US04410520,CCOC(=O)CN1C(=O)C(Cl)(Cl)CCc2ccccc21.O=S(=O)(O)O>>CCOC(=O)CN1C(=O)C(=O)CCc2ccccc21,,ClC(Cl)Cl,,C1COCCN1,,val
US20150087585A1,CC(C)(C)OC(=O)N1CCCC(c2ncc3n2CCC3)C1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.c1nc(C2CCCNC2)n2c1CCC2,,ClCCl,,,,val
US20150210640A1,CI.C[C@H](O)COCc1ccccc1>>CO[C@@H](C)COCc1ccccc1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US04788320,CC(=O)Nc1cc(F)c(F)cc1[N+](=O)[O-]>>Nc1cc(F)c(F)cc1[N+](=O)[O-],,CCO,Cl,,,val
US20160108026A1,O=C1CCc2c(Br)cncc21>>OC1CCc2c(Br)cncc21,,CCO,,[BH4-].[Na+],,val
US20120136016A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@@H](N)c1ccc([N+](=O)[O-])cc1>>C[C@H](NC(=O)OC(C)(C)C)c1ccc([N+](=O)[O-])cc1,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20060142278A1,CC(C)(C)OC(=O)N1C(CN=[N+]=[N-])C(c2cc(F)ccc2F)=CC1c1ccccc1>>NCC1NC(c2ccccc2)C=C1c1cc(F)ccc1F,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090209607A1,COc1sc(C(=O)O)cc1-c1ccnn1C.N[C@@H](Cc1ccccc1C(F)(F)F)CN1C(=O)c2ccccc2C1=O>>COc1sc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)cc1-c1ccnn1C,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20040087658A1,C=CC1(CC(N)=O)CC(C)(C)CC(C)(C)C1.Cl>>CC1CC2(C)CCNC(C)(C1)C2.Cl,,C1CCOC1,,B,,val
US20020102405A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>CC(C)(C)OC(=O)NCC(O)C(O)C(O)C(O)CO,,CN(C)C=O,,,,val
US20110021352A1,CCOC(=O)CC(=O)C(F)(F)F.Nc1ncc(Cl)cc1C=O>>CCOC(=O)c1cc2cc(Cl)cnc2nc1C(F)(F)F,,CCO,,C1CCNCC1,,val
US20140080822A1,COC(=O)c1c(N)ccc2c1CCn1nccc1-2.O=S(=O)(Cl)c1ccc(F)cc1Br>>COC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2Br)ccc2c1CCn1nccc1-2,,ClCCl,c1ccncc1,,,val
US05132319,ON=CCn1cc(Cc2ccccc2)c2ccccc21>>ONCCn1cc(Cc2ccccc2)c2ccccc21,,CCO,,Cl,,val
US05182272,O=Cc1ccccc1O.O=[N+]([O-])c1cc(C(F)(F)F)ccc1Cl>>O=Cc1ccccc1Oc1ccc(C(F)(F)F)cc1[N+](=O)[O-],,O,,[K],,val
US04939148,CNCc1ccc(C(C)(C)C)cc1.Fc1cc(F)c2cccc(CBr)c2c1>>CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2c(F)cc(F)cc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050038240A1,II.O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1>>O=c1ccn([C@@H]2O[C@H](CI)[C@@H](O)[C@H]2O)c(=O)[nH]1,,C1CCOC1,,c1c[nH]cn1,,val
US20030031629A1,C=C(C)C(=O)OCCO.CC(Cl)OC(=O)Cl>>C=C(C)C(=O)OCCOC(=O)OC(C)Cl,,ClCCl,,c1ccncc1,,val
US20090281084A1,CC(=O)OCc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc(-c2noc(=O)[nH]2)c(F)c1>>O=c1[nH]c(-c2ccc(OCc3sc(-c4ccc(C(F)(F)F)cc4)nc3CO)cc2F)no1,,CO,,[Na+].[OH-],,val
US20100216814A1,CC(=CBr)c1ccc(F)c(F)c1.CN1CCc2[nH]c3ccc(Cl)cc3c2C1>>C/C(=C\n1c2c(c3cc(Cl)ccc31)CN(C)CC2)c1ccc(F)c(F)c1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US04456465,CCP(=O)(O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-].O=C(OCCl)c1ccccc1>>CCP(=O)(OCOC(=O)c1ccccc1)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],,CN(C)C=O,,CCN(CC)CC,O,val
US20130059874A1,Cc1cc(Br)ccc1N1CCC2(CCC(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)CC2)C1=O>>Cc1cc(Br)ccc1N1CCC2(CCC(O)CC2)C1=O,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050234244A1,CCOC(=O)Cc1c(C)n(C(=O)c2ccc(Cl)cc2)c2cc(Cl)c(OC)cc12>>COc1cc2c(CC(=O)O)c(C)n(C(=O)c3ccc(Cl)cc3)c2cc1Cl,,CCOC(C)=O,,C1CCOC1,Cl,val
US20130281438A1,CN.Nc1c(C(=O)O)ccc2c1OCO2>>CNC(=O)c1ccc2c(c1N)OCO2,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080300242A1,COc1cc(N2CCN(C3CCN(C(=O)OC(C)(C)C)CC3)CC2)ccc1[N+](=O)[O-]>>COc1cc(N2CCN(C3CCNCC3)CC2)ccc1[N+](=O)[O-],,ClCCl,,O=C(O)C(F)(F)F,,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccccc2)c1C#N.SCCc1ccccn1>>N#Cc1c(SCCc2ccccn2)nc(N)nc1-c1ccccc1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20060014826A1,CC1(c2ccccc2)CCC(=O)CC1=O.O=C=Nc1cccc(C(F)(F)F)c1>>CC1(c2ccccc2)CCC(=O)C(C(=O)Nc2cccc(C(F)(F)F)c2)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20070021442A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Ic1n[nH]c2ncccc12>>CC(C)(C)OC(=O)n1nc(I)c2cccnc21,CN(C)c1ccncc1,CC#N,,CCN(CC)CC,,val
US20110114935A1,C1COCCOCCOCCOCCOCCO1.COc1ccc(I)cc1.Clc1ccccc1Cl.Nc1ccccc1>>COc1ccc(N(c2ccccc2)c2ccc(OC)cc2)cc1,[Cu],Clc1ccccc1Cl,,O=C([O-])[O-].[K+].[K+],,val
US04654343,CC(C)(C)C(=O)Cl.Cc1nnc2ccc(-c3cccc(N)c3)nn12>>Cc1nnc2ccc(-c3cccc(NC(=O)C(C)(C)C)c3)nn12,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US05137918,Nc1ccccc1[N+](=O)[O-].O=C(CCOCc1ccccc1)Nc1ccccc1C(=O)O>>O=C(CCOCc1ccccc1)Nc1ccc(C(=O)Nc2ccccc2[N+](=O)[O-])cc1,,CCOC(C)=O,c1ccncc1,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20070225267A1,CC(=O)Cl.CC1(CO[C@H]2CN(C(=O)OC(C)(C)C)[C@@H](C(O)C(N)Cc3cccc(OCc4ccccc4)c3)CO2)CCCC1>>CC(=O)N[C@@H](Cc1cccc(OCc2ccccc2)c1)[C@H](O)[C@H]1CO[C@@H](OCC2(C)CCCC2)CN1C(=O)OC(C)(C)C,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20130131039A1,C=C1CCOCC1.O=C(Cl)C(Cl)(Cl)Cl>>O=C1CC2(CCOCC2)C1(Cl)Cl,[Zn],CCOCC,,,,val
US20120101083A1,Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCNC2.O=C(Br)CBr>>Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(=O)CBr)C2,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20160185785A1,CC(C)(C)S(=O)N=C1COC1.Clc1cccc(Br)c1>>CC(C)(C)S(=O)NC1(c2cccc(Cl)c2)COC1,,C1CCOC1,,[Li]CCCC,,val
US06689922B1,CC(CCCC(C)(C)O)c1cccc(OCc2ccc(COC(C)(C)C(C)(C)C)c(CO[Si](C)(C)C(C)(C)C)c2)c1>>CC(CCCC(C)(C)O)c1cccc(OCc2ccc(CO)c(CO)c2)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140275002A1,COc1ccc([C@@H]2CN(C(=O)[C@@H]3COC(C)(C)O3)C[C@@]2(C)[C@@H](C)O)cc1O.CS(=O)(=O)OC1CN(C(c2ccccc2)c2ccccc2)C1>>COc1ccc([C@@H]2CN(C(=O)[C@@H]3COC(C)(C)O3)C[C@@]2(C)[C@@H](C)O)cc1OC1CN(C(c2ccccc2)c2ccccc2)C1,,CC#N,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20090082332A1,CCCCOc1nc(N)c2[nH]c(=O)n(CCCBr)c2n1.CN1CCC(N)CC1>>CCCCOc1nc(N)c2[nH]c(=O)n(CCCNC3CCN(C)CC3)c2n1,,CC#N,,Cl,,val
US20130123239A1,C=CCBr.CC(C)(C)OC(=O)N1CCN(c2ncc(Br)cc2F)CC1>>C=CCc1cnc(N2CCN(C(=O)OC(C)(C)C)CC2)c(F)c1,[Cu]I,C1CCOC1,,,,val
US20160096827A1,COC(=O)Cl.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@@H]1CCNC1>>COC(=O)N1CC[C@@H](Oc2ccc(-c3ncnc(Nc4ccc(N5CCN(C6COC6)CC5)cc4)n3)cc2C#N)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160075616A1,CCN(CC)P(Cl)Cl.c1ccc(Oc2ccccc2)cc1>>ClP1c2ccccc2Oc2ccccc21,,C1CCOC1,,[Li]CCCC,,val
US06127386,CN1CC[C@@H]1COc1cnc(Cl)c(-c2ccccc2)c1.Cl>>CN1CC[C@@H]1COc1cnc(Cl)c(-c2ccccc2)c1.Cl,,CCOCC,,CO,,val
US20100056565A1,Cc1cnc(C(=O)c2ccccc2)o1.Cl[Mg]C1CCCCC1>>Cc1cnc(C(O)(c2ccccc2)C2CCCCC2)o1,,C1CCOC1,O,CCOCC,[Cl-].[NH4+],val
US20160002204A1,COCCCBr.Nc1ccn(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)c(=O)n1>>COCCCNc1ccn(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)c(=O)n1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20090018147A1,COc1c(O)cccc1C=O.Cc1nc2ccccc2c(=O)n1-c1ccccc1>>O=c1c2ccccc2nc(C=Cc2cccc(O)c2O)n1-c1ccccc1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20140275084A1,CO.Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(C2CC2)cc1>>COC(=O)c1ccnc(-c2ncn(C)c2-c2ccc(C3CC3)cc2)c1,O=S(=O)(O)O,,,,,val
US20080004302A1,Cc1cc(CNc2nccc(Cl)n2)on1.Nc1cc(C2CCCC2)n[nH]1>>Cc1cc(CNc2nccc(Nc3cc(C4CCCC4)n[nH]3)n2)on1,,CCO,,,,val
US20090023724A1,Cc1cc(-c2cnc3[nH]c(=O)n(CC4CCOCC4)c3n2)ccc1-c1nc[nH]n1.Cc1cc(-c2cnc3[nH]c(=O)n(CCC4CCOCC4)c3n2)ccc1-c1ncn(C2CCCCO2)n1>>Cc1cc(-c2nc[nH]n2)ccc1-c1cnc2[nH]c(=O)n(CCC3CCOCC3)c2n1,,C1COCCO1,,Cl,,val
US05552404,CCNCC.O=C(O)c1cccc(I)c1>>CCN(CC)C(=O)c1cccc(I)c1,CN(C)C=O,C1CCOC1,CCOC(C)=O,O=C(Cl)C(=O)Cl,,val
US20120202792A1,C#Cc1cccc(F)c1.CCOC(=O)COc1ccc(Br)cc1[N+](=O)[O-]>>CCOC(=O)COc1ccc(C#Cc2cccc(F)c2)cc1[N+](=O)[O-],I[Cu]I,CN(C)C=O,,CCN(CC)CC,,val
US20090137588A1,CC(C)(C)OC(=O)Nc1cccc(Nc2cc(Cl)ncn2)c1.Oc1ccc(F)c(Cl)c1>>Nc1cccc(Nc2cc(Oc3ccc(F)c(Cl)c3)ncn2)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US06086905,CCCCCCCCCCCC(=O)Cl.O=C1NCCN1>>CCCCCCCCCCCC(=O)N1CCNC1=O,,Cc1ccccc1,,CCN(CC)CC,,val
US04299614,CCI.O=c1c(-c2ccccc2)c[nH]n1-c1cccc(C(F)(F)F)c1>>CCn1cc(-c2ccccc2)c(=O)n1-c1cccc(C(F)(F)F)c1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20140179666A1,CC[C@H]1CN(Cc2ccccc2)[C@H](C)CN1CC(=O)OCc1ccccc1>>CC[C@H]1CN[C@H](C)CN1CC(=O)O,[Pd],CO,,CC(=O)O,,val
US20080153871A1,Nc1cccc2ccc(O)cc12>>Nc1cccc2c1CC(O)CC2,[Ni],CCO,,[Na+].[OH-],,val
US20150011548A1,O=[N+]([O-])c1cc(Br)cc([N+](=O)[O-])c1>>Nc1cc(Br)cc([N+](=O)[O-])c1,[Fe],CC(=O)O,,,,val
US20150266857A1,CC(C)(C)OC(=O)NS(C)(=O)=O.O=S(=O)(c1ccccc1)n1cc(-c2ccc3nc(CCl)oc3c2)c2ccc(F)cc21>>CC(C)(C)OC(=O)N(Cc1nc2ccc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)cc2o1)S(C)(=O)=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120077799A1,Cc1cc(-c2cccnc2N)ccc1-c1ccccc1.O=S(=O)(Cl)CCCl>>Cc1cc(C2=CC=CN3CCS(=O)(=O)N=C23)ccc1-c1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20130123235A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.OCCc1occc1Br>>CC(C)(C)[Si](C)(C)OCCc1occc1Br,,ClCCl,,O,c1ccncc1,val
US20110237565A1,CC(C)(C)OC(=O)NC1CNC1.Clc1ncc(-c2cccs2)n2cnnc12>>CC(C)(C)OC(=O)NC1CN(c2ncc(-c3cccs3)n3cnnc23)C1,,CCO,,,,val
US20110003787A1,COCCN(CCOC)S(F)(F)F.COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(C3=NCC(CO)O3)[nH]2)c1>>COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(C3=NCC(CF)O3)[nH]2)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US04251539,CC(C)(C)N.Cc1cc(C=Cc2ccccc2OCC(O)CCl)on1>>Cc1cc(C=Cc2ccccc2OCC(O)CNC(C)(C)C)on1.Cl,,C1COCCO1,,,,val
US20060257987A1,CCOC(=O)C(Cc1ccc(O)cc1)OC.CCc1ccc(OC(C)CCO)c(C(=O)c2ccccc2)c1>>CCOC(=O)C(Cc1ccc(OCCC(C)Oc2ccc(CC)cc2C(=O)c2ccccc2)cc1)OC,,Cc1ccccc1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160009744A1,CC(C)[Si](O[C@H]1C[C@H](Nc2ncncc2C(=O)c2cc(Cc3ccc(C(F)(F)F)o3)cs2)C[C@@H]1CO[Si](C)(C)C(C)(C)C)(C(C)C)C(C)C>>CC(C)[Si](O[C@H]1C[C@H](Nc2ncncc2C(=O)c2cc(Cc3ccc(C(F)(F)F)o3)cs2)C[C@@H]1CO)(C(C)C)C(C)C,,CCO,,Cl,,val
US20110287937A1,COC(=O)c1cc2cccnc2n(C)c1=O.O=C1CCC(=O)N1Br>>COC(=O)c1cc2cccnc2n(CBr)c1=O,,ClC(Cl)(Cl)Cl,,O,,val
US20060142373A1,CCOC=C1C(=O)N(C(C)=O)c2cc(C(=O)OC)ccc21>>O=C1Nc2cc(C(=O)O)ccc2C1=CO,,CO,,Cl,[Na+].[OH-],val
US05840732,COc1ccccc1CCC=O.O=C1CSC(=O)N1CCCCSc1cccc2nccn12>>COc1ccccc1CCC=C1SC(=O)N(CCCCSc2cccc3nccn23)C1=O,,CCO,,C1CCNCC1,,val
US20140163110A1,Nc1ccccc1C(F)(F)F.O=S(=O)(Cl)c1ccc(Br)cc1>>O=S(=O)(Nc1ccccc1C(F)(F)F)c1ccc(Br)cc1,,ClCCl,,c1ccncc1,,val
US20060004043A1,Brc1ccc2cc(OCCN3CCCC3)ccc2c1.COB(OC)OC>>OB(O)c1ccc2cc(OCCN3CCCC3)ccc2c1,,C1CCOC1,O,[Li]CCCC,[Cl-].[NH4+],val
US20130035318A1,C=C(C)[C@@H]1CC[C@]2(NC(=O)OC(C)(C)C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>C=C(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(OS(=O)(=O)C(F)(F)F)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20080125429A1,COC(=O)c1cc(F)ccc1[N+](=O)[O-].Cc1nc(-c2ccc(O)cn2)no1>>COC(=O)c1cc(Oc2ccc(-c3noc(C)n3)nc2)ccc1[N+](=O)[O-],,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US05502054,C[Si](C)(C)CCC(=O)O.O=C(Cl)C(=O)Cl>>C[Si](C)(C)CCC(=O)Cl,CN(C)C=O,CCOCC,,,,val
US06124323,Cl.Fc1ccc(CC2CCNCC2)cc1.O=CCSc1ccc(O)cc1>>Cl.Oc1ccc(SCCN2CCC(Cc3ccc(F)cc3)CC2)cc1,,CO,,,,val
US20140296313A1,O=C(CBr)c1ccc(OC(F)(F)F)cc1.O=C(O)CC1(NC(=O)OCc2ccccc2)COC1>>O=C(CC1(NC(=O)OCc2ccccc2)COC1)OCC(=O)c1ccc(OC(F)(F)F)cc1,,CCOC(C)=O,,CCN(CC)CC,,val
US20050171174A1,CC(=O)OC(C)=O.N#Cc1ccc(C[C@@]23C[C@H](N)CN2C(=O)N(c2cc(Cl)cc(Cl)c2)C3=O)cc1>>CC(=O)N[C@@H]1CN2C(=O)N(c3cc(Cl)cc(Cl)c3)C(=O)[C@]2(Cc2ccc(C#N)cc2)C1,,C1CCOC1,,,,val
US20100063054A1,CC(c1ccc(N)nn1)c1nnc2ccc(Br)cn12.N#CCBr>>CC(c1ccc2nc(N)cn2n1)c1nnc2ccc(Br)cn12,,CC(C)O,,O=C([O-])O.[Na+],,val
US20160244860A1,CC(C)=O.CCCCCCCCCC(C)=O.CCOC(=O)C(=O)OCC.Cc1ccccc1>>CCCCCCCCCC(=O)CC(=O)C(=O)CC(=O)CCCCCCCCC,,CC(C)=O,,[H-].[Na+],,val
US20160000784A1,CN(C)/C=C/C(=O)c1ccc(N2CC[C@H](O)C2)c(C#N)n1.N=C(N)Nc1ccc(N2CCOCC2)cc1>>N#Cc1nc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)ccc1N1CC[C@H](O)C1,,CCO,,,,val
US20050065210A1,CC(O[C@@H]1CC[C@@H](N(C)S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1)C(=O)OC(C)(C)C>>CC(O[C@@H]1CC[C@@H](N(C)S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04514416,CS(=O)(=O)O.N=C(N)c1ccc(O)c(C(=O)O)c1>>CS(=O)(=O)O.N=C(N)c1ccc(O)c(C(=O)O)c1,,CCOCC,,,,val
US05932599,CNc1cc(NS(=O)(=O)c2ccc(NC(C)=O)cc2)nc(N2CCCC2)n1>>CNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(N2CCCC2)n1,,[Na+],[OH-],,,val
US04115398,Cl.O=[N+]([O-])c1cccc(C=CCCl)c1.c1ccc2c(c1)CNC2>>Cl.O=[N+]([O-])c1cccc(C=CCN2Cc3ccccc3C2)c1,,CCO,O,[Na+].[OH-],,val
US20080242663A1,CCOC(=O)c1cc(Nc2nccc(N(C)c3cc(CO)ccc3C)n2)cc(N2CCOCC2)c1>>Cc1ccc(CO)cc1N(C)c1ccnc(Nc2cc(C(=O)O)cc(N3CCOCC3)c2)n1,,CO,,O,[Na+].[OH-],val
US20080032995A1,COc1ccc(-c2coc3cc(OCC(O)CNCc4cccc(C(F)(F)F)c4)ccc3c2=O)cc1>>O=c1c(-c2ccc(O)cc2)coc2cc(OCC(O)CNCc3cccc(C(F)(F)F)c3)ccc12,,ClCCl,,BrB(Br)Br,,val
US20100029737A1,COC(=O)c1cc2c(n1C(=O)OC(C)(C)C)CCC2Cc1cccc(C#C[Si](C)(C)C)c1>>C#Cc1cccc(CC2CCc3[nH]c(C(=O)OC)cc32)c1,O=C(O)C(F)(F)F,C1CCOC1,,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20040006081A1,CC(C)(C)OC(=O)N1CCC(NC(=O)N(CCc2ccccc2)c2ccc(F)cc2F)CC1>>NC(=O)N(CCc1ccccc1)C1=C(F)CC(F)(N2CCCCC2)C=C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060135578A1,COC(=O)c1cccc(-c2nc(CCl)c(C)o2)c1.COc1cc(C=O)ccc1O>>COC(=O)c1cccc(-c2nc(COc3ccc(C=O)cc3OC)c(C)o2)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070004753A1,Nc1ccc(CCCC(=O)O)cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(O)CCCc1ccc(NC(=O)C(F)(F)F)cc1,,ClC(Cl)Cl,,,,val
US06235731B1,CCOC(=O)C1Cc2cnc3cccc(n23)S1>>O=C(O)C1Cc2cnc3cccc(n23)S1,,CCO,,Cl,[Na+].[OH-],val
US20080081818A1,O=C(NCc1ccc(OC(F)(F)F)cc1)[C@H]1CNCCN1S(=O)(=O)c1ccc(OC(F)(F)F)cc1.O=c1[nH]ncc2nc(Cl)sc12>>O=C(NCc1ccc(OC(F)(F)F)cc1)[C@H]1CN(c2nc3cn[nH]c(=O)c3s2)CCN1S(=O)(=O)c1ccc(OC(F)(F)F)cc1,,CCN(CC)CC,,CC(C)O,,val
US09248117B2,CC(C)(CNCCO)[N+](=O)[O-]>>CC(C)(N)CNCCO,[Ni],CO,O,,,val
US20130225608A1,Cc1ccccc1.N=C(N)Nc1ccc(F)c(F)c1F.O=C(O)O>>Oc1nc(Nc2ccc(F)c(F)c2F)nc2c1CCCC2,,O,,,,val
US20120270838A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccccc1CCS(=O)(=O)N1CCC2(CC1)N=C(C1CCCCC1)NC2=O>>Cc1ccccc1CCS(=O)(=O)N1CCC2(CC1)N=C(C1CCCCC1)NC2=S,,Cc1ccccc1,,,,val
US20130137852A1,CC(C)(C)OC(=O)N1CCCC1C(=O)NC(CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F.Cl>>Cl.O=C(NC(CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F)C1CCCN1,,CCOC(C)=O,,,,val
US20040147748A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1cnc(C#N)cn1.NO>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1cnc(C(=N)NO)cn1,,CS(C)=O,,C1CCNCC1,Cl,val
US20140045855A1,O=C(Cl)C(=O)Cl.O=C(O)c1ccc2[nH]c(=O)c(=O)[nH]c2c1>>O=C(Cl)c1ccc2[nH]c(=O)c(=O)[nH]c2c1,,ClCCl,,CN(C)C=O,,val
US20100144745A1,C=CCBr.Nc1ncc(Br)nc1Br>>C=CCNc1ncc(Br)nc1Br,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20080096877A1,COC(OC)C(C)(CNC(=O)c1cc2cccc(N(C)S(=O)(=O)c3cccs3)c2[nH]1)SCc1ccccc1>>CN(c1cccc2cc(C(=O)NCC(C)(C=O)SCc3ccccc3)[nH]c12)S(=O)(=O)c1cccs1,,CC(C)=O,,O,,val
US20100190766A1,O=C(NCCNO)c1ccc(C#Cc2ccc(CN3CCOCC3)cc2)cc1.O=COCC(F)(F)F>>O=CN(O)CCNC(=O)c1ccc(C#Cc2ccc(CN3CCOCC3)cc2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20100113462A1,CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2c(F)ccc(F)c2C1>>Cc1cccc(C(=O)NC2(C(=O)O)Cc3c(F)ccc(F)c3C2)c1CC(C)C,[Pd],CO,,,,val
US04125538,CNC.O=C(CCl)N1CCOc2ccc(Cl)cc2C1c1ccccc1>>CN(C)CC(=O)N1CCOc2ccc(Cl)cc2C1c1ccccc1,,ClCCl,,,,val
US20020107278A1,Cl.Fc1ccccc1-c1cccc2[nH]c3c(c12)CCN(Cc1ccccc1)CC3>>Cl.Fc1ccccc1-c1cccc2[nH]c3c(c12)CCNCC3,[Pd],CCO,,,,val
US20040006141A1,C1COCCO1.CCCC(Cc1ccc(OCCNC(=O)OC(C)(C)C)cc1)C(=O)OCC.CCN(CC)CC.CCOP(=O)(C#N)OCC.CN(C)C=O.Cl>>CCCC(Cc1ccc(OCCN)cc1)C(=O)OCC.Cl.O=C(O)c1ccc(-c2ccccn2)cc1,,C1COCCO1,CN(C)C=O,,,val
US20110053959A1,COc1ccc(CCl)cc1.N#Cc1cccc2[nH]ccc12>>COc1ccc(Cn2ccc3c(C#N)cccc32)cc1,,O,,CN(C)C=O,[H-].[Na+],val
US20140206666A1,NC1CCCC1.O=C(O)c1cc(S(=O)(=O)Cl)ccc1F>>O=C(O)c1cc(S(=O)(=O)NC2CCCC2)ccc1F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080085886A1,CCOC(=O)C#N.Clc1ccnc(Cl)c1>>CCOC(=O)c1c(Cl)ccnc1Cl,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US04739106,CCOC(=O)C#CCOC(=O)Cl.CNCc1ccccc1>>CCOC(=O)C#CCOC(=O)N(C)Cc1ccccc1,,ClCCl,,Cl,,val
US20060111413A1,[N-]=[N+]=N[C@@H]1Cc2ccccc2C[C@H]1O>>N[C@@H]1Cc2ccccc2C[C@H]1O,[Pd],CO,,,,val
US04265815,CSC1=CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C.Cc1ccc(SCl)cc1>>CSC1=C(Sc2ccc(C)cc2)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C,,ClCCl,,,,val
US20090069296A1,CCOc1ccc2c(c1)CC2C#N>>CCOc1ccc2c(c1)CC2CN,[Ni],CO,,,,val
US20110152519A1,CC(=O)OC(C)=O.Nc1c(N2CCOCC2)nc(N2CCN(c3ccccc3)CC2)nc1N1CCOCC1>>CC(=O)Nc1c(N2CCOCC2)nc(N2CCN(c3ccccc3)CC2)nc1N1CCOCC1,c1ccncc1,,,,,val
US20140371199A1,Clc1ccc(-c2cnc3cnc(Br)cn23)cc1.O=C(O)c1ccc(B(O)O)cc1>>O=C(O)c1ccc(-c2cn3c(-c4ccc(Cl)cc4)cnc3cn2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20110142856A1,CC(C)(C)OC(=O)NCCCCN(Cc1ccc(C(=O)N(Cc2nccn2COCC[Si](C)(C)C)Cc2nccn2COCC[Si](C)(C)C)cc1)C(=O)OCc1ccccc1>>C[Si](C)(C)CCOCn1ccnc1CN(Cc1nccn1COCC[Si](C)(C)C)C(=O)c1ccc(CN(CCCCN)C(=O)OCc2ccccc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150057265A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1c(N)sc2ccc(Cl)nc12>>CCOC(=O)c1c(NC(=O)OC(C)(C)C)sc2ccc(Cl)nc12,CN(C)c1ccncc1,CC#N,,,,val
US20080045556A1,COC(=O)c1ccc(-c2csc(N3C(=O)OCC3(C)C)n2)cc1.O=C1CCC(=O)N1Cl>>COC(=O)c1ccc(-c2nc(N3C(=O)OCC3(C)C)sc2Cl)cc1,,CN(C)C=O,,,,val
US20070015788A1,CS(=O)(=O)c1ccc([C@@H](CCO)c2cc(F)cc(F)c2)cc1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)cc1,,c1ccncc1,,,,val
US06407096B1,COC(=O)CBr.O=C(CN1C(=O)COc2c(O)cccc21)NC(c1ccccc1)c1ccccc1>>COC(=O)COc1cccc2c1OCC(=O)N2CC(=O)NC(c1ccccc1)c1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05283243,O=C(c1ccc(F)cc1)C1CCNCC1.O=C1Nc2ccccc2SC1Cl>>O=C(c1ccc(F)cc1)C1CCN(C2Sc3ccccc3NC2=O)CC1,,Cc1ccccc1,O,CCN(CC)CC,Cl,val
US04617312,COC(Cl)Cl.COc1ccc(Cl)cc1C>>COc1c(C)cc(Cl)cc1C=O,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20100105744A1,CSCc1cccc2c(C(C)(c3ccc(Cl)cc3F)C3CC3)c[nH]c12.O=C(OO)c1cccc(Cl)c1>>CS(=O)Cc1cccc2c(C(C)(c3ccc(Cl)cc3F)C3CC3)c[nH]c12,,CO,,ClCCl,,val
US05696276,CC(C)=CC[C@@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O.CCCC(=O)O>>CCCC(=O)OC(CC=C(C)C)C1=CC(=O)c2c(O)ccc(O)c2C1=O,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130109711A1,C=CCBr.COC(=O)C1CCCN(C(=O)OC(C)(C)C)C1>>C=CCC1(C(=O)OC)CCCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](O[C@@H]3CCC[C@@H]3O)CC2)c2ncnn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](O[C@@H]3CCC[C@@H]3O)CC2)c2ncnn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20150361126A1,CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CC(C=O)=C(Cl)[C@@]4(C)CC[C@@H]32)C1.Clc1ncnc2nc[nH]c12>>CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CC(C=O)=C(n5cnc6c(Cl)ncnc65)[C@@]4(C)CC[C@@H]32)C1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150152108A1,CC1(C)OC[C@H](CO)O1.Nc1ccnc(Cl)n1>>CC1(C)OC[C@H](COc2nccc(N)n2)O1,,C1CCOC1,,[H-].[Na+],,val
US20160108041A1,Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOCCO[Si](C)(C)C(C)(C)C)c2c(c1=O)CC(C)(C)C2>>NC(=O)C1=CNCC2=C1CCC2,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140194647A1,CC(C)CBr.CCOC(=O)CC(C(=O)OCC)C(=O)OCC>>CCOC(=O)CC(CC(C)C)(C(=O)OCC)C(=O)OCC,,O,,CN(C)C=O,[H-].[Na+],val
US06469017B1,Cn1cnc2[nH]c(=O)[nH]c(=O)c21.N#CCCCCCBr>>Cn1cnc2c1c(=O)[nH]c(=O)n2CCCCCC#N,,CS(C)=O,,[H-].[Na+],,val
US06130239,C#C[Si](C)(C)C.COc1cc[nH]c1/C=C1\C(=O)Nc2ccc([N+](=O)[O-])c(Br)c21>>COc1cc[nH]c1/C=C1\C(=O)Nc2cccc(C#C[Si](C)(C)C)c21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCN(CC)CC,CN(C)C=O,,,val
US05719182,COC(=O)C1C(=O)c2cc(OCc3ccccc3)ccc2C1c1ccc2c(c1)OCO2>>COC(=O)C1=C(c2ccc3c(c2)OCO3)c2ccc(OCc3ccccc3)cc2C1=O,,c1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20100286145A1,CC(C)c1ccnc(C#N)c1>>CC(C)c1ccnc(CN)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030225138A1,CC(C)(C)C=O.CCOC(=O)[C@H](C)N>>CCOC(=O)[C@H](C)N=CC(C)(C)C,,ClCCl,,O=S(=O)([O-])[O-].[Mg+2],,val
US20090030195A1,CC(C)(C)[Si](C)(C)OCCOC1COC(c2ccccc2)OC1>>OCCOC1COC(c2ccccc2)OC1,,C1CCOC1,,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20030119895A1,Cc1cc(C)c(C=O)[nH]1.O=C1Cc2ccccc2N1>>Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1,C1CCNCC1,CCO,,,,val
US04108885,CCCOC(=O)NCCCN(C)C.O=S(=O)(O)O>>CCCOC(=O)NCCC[NH+](C)C.O=S(=O)([O-])O,,CCOCC,,,,val
US20080188473A1,CCOC(=O)c1c([N+](=O)[O-])c2cc(-c3ccc(C(C)(C)C)cc3)ccc2n1-c1ccc(OC(C)C)cc1>>CCOC(=O)c1c(N)c2cc(-c3ccc(C(C)(C)C)cc3)ccc2n1-c1ccc(OC(C)C)cc1,[Pd],CCOC(C)=O,,,,val
US20100016314A1,COC(=O)Cl.O=C1CC2CNCC2C1>>COC(=O)N1CC2CC(=O)CC2C1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100152190A1,COc1cc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(c3ccc(Cl)cc3F)[C@H]2c2cccc(Cl)c2F)ccc1C(=O)O.N>>COc1cc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(c3ccc(Cl)cc3F)[C@H]2c2cccc(Cl)c2F)ccc1C(N)=O,,CO,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US08623880B2,CC(C)(C)COc1ccc(-c2csc(NC(=O)CBr)n2)cc1F.Cc1c2c(=O)n(C)c(=O)n(C)c2nn1C>>Cc1cc2c(c(=O)n(C)c(=O)n2C)n1CC(=O)Nc1nc(-c2ccc(OCC(C)(C)C)c(F)c2)cs1,,CN(C)C=O,,[H-].[Na+],,val
US05378715,CC(C)=O.Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C>>Cc1noc(NS(=O)(=O)c2cccc3c(NC(C)C)cccc23)c1C,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20150291640A1,CC(C)(C)[Si](C)(C)O[C@@H]1CCC[C@H](NC(=O)OCc2ccccc2)C1>>CC(C)(C)[Si](C)(C)OC1CCCC(N)C1,[Pd],CO,,[H][H],,val
US20100075998A1,CCOC(=O)c1cn(C)c2c1CCc1cnc(N)nc1-2>>Cn1cc(C(=O)O)c2c1-c1nc(N)ncc1CC2,,CCO,,[K+].[OH-],,val
US06566376B1,O=Cc1cn(Cc2ccc(Cl)cc2)nc1CN1CCC(c2ccccc2)(c2ccccc2)CC1.OCCN1CCNCC1>>OCCN1CCN(Cc2cn(Cc3ccc(Cl)cc3)nc2CN2CCC(c3ccccc3)(c3ccccc3)CC2)CC1,CC(=O)O,CN(C)C=O,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20150291597A1,C#CCNc1nc(Cl)nc(N(C)OC)n1.CC(O)CN>>C#CCNc1nc(NCC(C)O)nc(N(C)OC)n1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US05599816,CC(C)(C)OC(=O)N1CCC[C@H]1[C@H](CCO)C[N+](=O)[O-].CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCC[C@H]1[C@H](CCOS(C)(=O)=O)C[N+](=O)[O-],,ClCCl,,,,val
US20150291604A1,C[C@H]1COCCN1c1nc(-c2cnc(N)nc2)c2c(n1)N([C@@]1(C)CCN(C(=O)OC(C)(C)C)C1)CC2.Cl>>C[C@H]1COCCN1c1nc(-c2cnc(N)nc2)c2c(n1)N([C@@]1(C)CCNC1)CC2.Cl,,CO,Cc1ccccc1,C1COCCO1,,val
US06348472B1,O=C1NC2(CCCCN2)C(Cc2ccccc2)c2ccccc21>>O=C1NC2(CCCCN2)Cc2ccccc21,,ClCCl,,CC(Cl)OC(=O)Cl,,val
US20090093483A1,BrCCOCCBr.COC(=O)Cc1ccccc1>>COC(=O)C1(c2ccccc2)CCOCC1,,CN1CCCC1=O,,[H-].[Na+],,val
US20120184553A1,Nc1cccnc1.O=C(O)c1cc(C(=O)N2CCCCC2)ccc1OCc1ccccc1>>O=C(Nc1cccnc1)c1cc(C(=O)N2CCCCC2)ccc1OCc1ccccc1,,CN(C)C=O,O,ClCCCl,On1nnc2ccccc21,val
US20140275080A1,COCCOCn1ccnc1C(C)C.C[Sn](C)(C)Cl>>COCCOCn1c([Sn](C)(C)C)cnc1C(C)C,,C1CCOC1,CCOC(C)=O,[Li]CCCC,,val
US20120122844A1,CCOC(=O)[C@@H](C)CC(N)Cc1ccc(-c2ccccc2OC)cc1.O=C1CCC(=O)O1>>CCOC(=O)[C@@H](C)CC(Cc1ccc(-c2ccccc2OC)cc1)NC(=O)CCC(=O)O,,ClCCl,c1ccncc1,Cl,,val
US05236925,NC(=O)c1cc(Cl)ccc1[N+](=O)[O-]>>NC(=O)c1cc(Cl)ccc1N,[Fe],CC(=O)O,,,,val
US20150353553A1,C[C@@H]1CC[C@@H](Cn2c(Br)nc3nc(Cl)nc(-c4cccc(Cl)c4)c32)CC1.C[C@@H]1COCCN1>>C[C@H]1CC[C@H](Cn2c(N3CCOC[C@H]3C)nc3nc(Cl)nc(-c4cccc(Cl)c4)c32)CC1,,CS(C)=O,O,[F-].[K+],,val
US20130035349A1,CC(C)C(Cl)=C(C#N)C#N.NNc1ncc(Cl)cc1Cl>>CC(C)C1=NN(c2ncc(Cl)cc2Cl)C(N)C1C#N,,C1CCOC1,,CCN(CC)CC,,val
US05753634,CC(=O)SCCBr.CN1CCCC2CC(P(=O)(O)O)(P(=O)(O)O)CC21>>CC(=O)SCC[N+]1(C)CCCC2CC(P(=O)(O)O)(P(=O)(O)O)CC21.[Br-],,CS(C)=O,O,C,,val
US20070197537A1,Nc1ccc(Oc2ccnc3cc(I)sc23)c(F)c1.OB(O)c1ccccc1>>Nc1ccc(Oc2ccnc3cc(-c4ccccc4)sc23)c(F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[Cs+].[Cs+],val
US04764522,CCN(CC)CC.O=C(NCCO)c1ccccn1>>NCCNC(=O)c1ccccn1,,ClCCl,,,,val
US20100292206A1,CC(C)(C)c1ccccc1OC1CN(C(c2ccccc2)c2ccccc2)C1>>CC(C)(C)c1ccccc1OC1CNC1,[Pd],CO,,,,val
US20090247507A1,COc1ccc(C=O)cc1.Nc1ncc(Cl)c(N2CCN(Cc3ccncc3)CC2)c1[N+](=O)[O-]>>COc1ccc(-c2nc3c(N4CCN(Cc5ccncc5)CC4)c(Cl)cnc3[nH]2)cc1,,CCO,,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20100210704A1,Cc1cc(F)c(-n2nc(OCC(F)(F)C(F)(F)F)cc2N)cc1SCC(F)(F)F.O=C1CCC(=O)N1Cl>>Cc1cc(F)c(-n2nc(OCC(F)(F)C(F)(F)F)c(Cl)c2N)cc1SCC(F)(F)F,,CC#N,,,,val
US20060165764A1,CCCCCCCCCCCCCC(=O)OC(C)C.CCOC(C)=O.COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O.[N-]=C=O>>C=CC(=O)O.C=CC(=O)OCC(CC)CCCC.C=CN1CCCC1=O,,CCOC(C)=O,,,,val
US20030182736A1,CC(=O)OC(C)=O.CC1=CC(=O)C=CC1=NO>>CC(=O)ON=C1C=CC(=O)C=C1C,c1ccncc1,,,,,val
US20110053916A1,CC(C)(C)NS(=O)(=O)c1ccc(-c2ncc(C#CCO)c(Nc3cc(C4CC4)[nH]n3)n2)s1>>CC(C)(C)NS(=O)(=O)c1ccc(-c2ncc(/C=C/CO)c(Nc3cc(C4CC4)[nH]n3)n2)s1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05216148,CCOC(=O)c1ccc(C(=O)Cl)cc1.CN1C(=O)CC(C)(C)c2cc(N)ccc21>>CCOC(=O)c1ccc(C(=O)Nc2ccc3c(c2)C(C)(C)CC(=O)N3C)cc1,,C1CCOC1,c1ccncc1,,,val
US20140051672A1,CN(c1ccc(-c2ccc(OS(=O)(=O)C(F)(F)F)cc2O)nn1)C1CC(C)(C)NC(C)(C)C1.COc1cncc(B2OC(C)(C)C(C)(C)O2)c1>>COc1cncc(-c2ccc(-c3ccc(N(C)C4CC(C)(C)NC(C)(C)C4)nn3)c(O)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])O.[Na+],val
US20150225422A1,CC1CCCCN1.N#Cc1ncc(Br)cc1F>>CC1CCCCN1c1cc(Br)cnc1C#N,,C1CCOC1,O,CCN(C(C)C)C(C)C,,val
US20050107428A1,CCO.CN(C)C=O.Clc1ccc(ON2CCCCC2)cc1Cl.O=C1NC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1C[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1,,CCO,,,,val
US20120208840A1,CC(C)=O.Fc1cccnc1>>CC(C)(O)c1ccncc1F,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20150119385A1,CN(C)CCO.N#Cc1cnc(N)cc1F>>CN(C)CCOc1cc(N)ncc1C#N,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20120238559A1,Cc1ccc(S(=O)(=O)n2c(Cl)cc3c(Br)cccc32)cc1>>Clc1cc2c(Br)cccc2[nH]1,,CC(C)O,,Cl,[Na+].[OH-],val
US20010021714A1,COc1ccc(Cc2sc3ccccc3c2S(=O)(=O)Cl)cc1.Cc1noc(N)c1Br>>COc1ccc(Cc2sc3ccccc3c2S(=O)(=O)Nc2onc(C)c2Br)cc1,,C1CCOC1,,[H-].[Na+],,val
US20090105217A1,NNC(=O)c1ccc([N+](=O)[O-])cc1.S=C=NCCCN1CCCCC1>>O=C(NNC(=S)NCCCN1CCCCC1)c1ccc([N+](=O)[O-])cc1,,CN(C)C=O,,,,val
US03975418,Nc1ccc(Br)c(Cl)c1.O=C(Cl)Cl>>O=C=Nc1ccc(Br)c(Cl)c1,,Clc1ccccc1,,Cl,Cl,val
US04552585,CCBr.Cc1ccc(N(C(=O)[O-])C(C)(C)C)cc1Cl>>CCN(C(=O)OC(C)(C)C)c1ccc(C)c(Cl)c1,,CCOCC,,C1CCOC1,,val
US20140235660A1,CCOC(=O)/C(C)=C/c1ccc(O)cc1.COc1ccc(C2=C(Br)c3ccc(OC)cc3S2=O)cc1>>CCOC(=O)/C(C)=C/c1ccc(OC2=C(c3ccc(OC)cc3)S(=O)c3cc(OC)ccc32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20150344437A1,CCOC(=O)C(C)C(C)=O.CS(=O)(=O)c1ccc(NN)cc1>>Cc1nn(-c2ccc(S(C)(=O)=O)cc2)c(O)c1C,,CCO,,CCN(CC)CC,Cl,val
US20110034507A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1CO.COC(=O)c1cccc(-c2ccc3cc(O)ccc3c2)c1>>COC(=O)c1cccc(-c2ccc3cc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)ccc3c2)c1,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05654436,Clc1ccc(CBr)cc1Cl.c1ccc(-c2nc3ccccc3[nH]2)nc1>>Clc1ccc(Cn2c(-c3ccccn3)nc3ccccc32)cc1Cl,,CN(C)C=O,O,[H-].[Na+],,val
US04097669,ClCc1ccccc1Cl.FC(F)(F)c1nnc(S)s1>>FC(F)(F)c1nnc(SCc2ccccc2Cl)s1,,CCO,,CCN(CC)CC,,val
US20060041146A1,C[C@@H](c1ccccc1)[C@H](NC(=O)OC(C)(C)C)C(=O)O.Fc1nc(F)nc(F)n1>>C[C@@H](c1ccccc1)[C@H](NC(=O)OC(C)(C)C)C(=O)F,,ClCCl,,c1ccncc1,,val
US06337064B1,C1COCCO1.N[C@@H](Cc1ccccc1)C(=O)O>>CC(C)(C)OC(=O)[C@@H](N)Cc1ccccc1,,C1COCCO1,,O=S(=O)(O)O,[Na+].[OH-],val
US20140005213A1,CC(C)(C)c1cccc2ccc(C=O)nc12.COC(=O)c1ccc(NN)nc1>>COC(=O)c1ccc(N/N=C/c2ccc3cccc(C(C)(C)C)c3n2)nc1,,CCO,,,,val
US20030078251A1,CCOC(=O)COc1ccc(CCNC(=O)C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)CO)C2=O)cc1>>COc1cccc([C@H]2O[C@H](CC(=O)NCCc3ccc(OCC(=O)O)cc3)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,O,,CCO,[Na+].[OH-],val
US20090163533A1,CCn1nc2c(N)nc3ccccc3c2c1CC1(O)CCNCC1.CS(=O)(=O)OS(C)(=O)=O>>CCn1nc2c(N)nc3ccccc3c2c1CC1(O)CCN(S(C)(=O)=O)CC1,,ClC(Cl)Cl,,O=C([O-])[O-].[Na+].[Na+],,val
US20120077828A1,CI.Cc1cccc(CC(=O)N2CCc3cc(-c4cn(C5CCNCC5)c5ncnc(N)c45)ccc32)c1>>Cc1cccc(CC(=O)N2CCc3cc(-c4cn(C5CCN(C)CC5)c5ncnc(N)c45)ccc32)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US07342027B2,CCOC(=O)Cl.Nc1ccccc1N1CCC(NC(=O)C2(NC(=O)c3cc4ccccc4o3)CCCCC2)C(O)C1>>CCOC(=O)Nc1ccccc1N1CCC(NC(=O)C2(NC(=O)c3cc4ccccc4o3)CCCCC2)C(O)C1,,ClCCl,,CCN(CC)CC,,val
US20120088767A1,C1COCCN1.COC(=O)c1cc(Cl)cc(N)c1[N+](=O)[O-]>>COC(=O)c1cc(N2CCOCC2)cc(N)c1[N+](=O)[O-],,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04343803,CN(C)C(=O)Cl.Cc1cc(O)nc(C(Cl)(Cl)Cl)n1>>Cc1cc(OC(=O)N(C)C)nc(C(Cl)(Cl)Cl)n1,,CC#N,,CCN(CC)CC,,val
US20120178623A1,COC1=C(c2c(C)cc(C)cc2C)C(=O)C(C(O)C2CCC(OCc3ccccc3)CC2)C1>>COC1CCC(/C=C2\CC(=O)C(c3c(C)cc(C)cc3C)C2=O)CC1,,CC(C)=O,O,Cl,,val
US04824958,CC(C)Oc1c(Br)c(Br)n(-c2ccccc2)c1C(=O)O.Nc1nnn[nH]1>>CC(C)Oc1c(Br)c(Br)n(-c2ccccc2)c1C(=O)Nc1nnn[nH]1,,C1CCOC1,,Cl,O=C(n1ccnc1)n1ccnc1,val
US20140179668A1,CCOC(=O)[C@@H]1CCCN1c1nc2c(c(Nc3cc(C(C)C)[nH]n3)n1)CCC2.CNc1ccc(F)nc1>>CC(C)c1cc(Nc2nc(N3CCC[C@H]3C(=O)N(C)c3ccc(F)nc3)nc3c2CCC3)n[nH]1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20120226036A1,Cc1oc(=O)oc1CCl.O=C(O)CNc1cccc(C(NCc2ccc(-c3nccs3)cc2)S(=O)(=O)c2ccccn2)n1>>Cc1oc(=O)oc1COC(=O)CNc1cccc(C(NCc2ccc(-c3nccs3)cc2)S(=O)(=O)c2ccccn2)n1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20080160356A1,CCOP(=O)(OCC)c1cc(P(=O)(OCC)OCC)c2ccc3c(P(=O)(OCC)OCC)cc(P(=O)(OCC)OCC)c4ccc1c2c43>>O=P(O)(O)c1cc(P(=O)(O)O)c2ccc3c(P(=O)(O)O)cc(P(=O)(O)O)c4ccc1c2c43,,Cl,,,,val
US20110207728A1,O=C(Cl)C(Cl)(Cl)Cl.O=C(Cn1cccc1)c1ccc(C(F)(F)F)cn1>>O=C(Cn1cccc1C(=O)C(Cl)(Cl)Cl)c1ccc(C(F)(F)F)cn1,,ClCCl,,,,val
US20100004239A1,CC(C)(C)OC(=O)NCCC(O)=C1C(=O)OC(C)(C)OC1=O>>CC(C)(C)OC(=O)N1CCC(=O)CC1=O,,C1COCCO1,,,,val
US20030065189A1,CCOC(=S)OCC.FCC1(CF)C=C(Br)c2cc(C(F)(F)F)ccc2O1>>CCOC(=S)C1=CC(CF)(CF)Oc2ccc(C(F)(F)F)cc21,,COC(C)(C)C,,[Li]CCCC,[Cl-].[NH4+],val
US20120298932A1,CCCCCCCCCCCBr.Oc1ccc(O)cc1>>CCCCCCCCCCCOc1ccc(O)cc1,,CCC(C)=O,,[I-].[K+],,val
US20050171353A1,CC(C)N=C=NC(C)C.CCN(CC)CC.COC(=O)C[C@H](N)c1ccccc1.O=C(O)C1CCC(F)(F)CC1>>CCCC(C)C.O=C(N[C@@H](CCO)c1ccccc1)C1CCC(F)(F)CC1,,ClCCl,,Cl,,val
US20070066589A1,Nc1ccccc1S(=O)(=O)c1ccccc1C(=O)O>>O=C1Nc2ccccc2Sc2ccccc21,,Cc1ccccc1C,,O=S(=O)(O)O,,val
US04683296,CC(O)[Si](C)(C)C.CCOC(=O)CC(C)=O>>CC(=O)CC(=O)O[Si](C)(C)C,,Cc1ccccc1,,,,val
US20150210739A1,CC(C)(C)OC(=O)N1CCc2ccccc2[C@H]1C(=O)O.Nc1c(F)cccc1F>>CC(C)(C)OC(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F,,c1ccncc1,,O=P(Cl)(Cl)Cl,,val
US20090143444A1,C1CCOC1.CN.CO.CO.O.O=Cc1cn(S(=O)(=O)c2cccnc2)c(-c2ccccc2F)c1Cl>>CNCc1cn(S(=O)(=O)c2cccnc2)c(-c2ccccc2F)c1Cl.O=C(O)/C=C/C(=O)O,,CO,,[BH4-].[Na+],,val
US04647566,CCOC(=O)c1cnc2c(c1Cl)CC(C)(OCc1ccccc1)CC2.NNc1ccc(Cl)cc1>>CC1(OCc2ccccc2)CCc2[nH]cc3c(=O)n(-c4ccc(Cl)cc4)nc-3c2C1,,CCCCO,,,,val
US20150336938A1,CI.COc1cc2c(O)c3c(c(-c4ccsc4)c2cc1OC)C(=O)OC3>>COc1cc2c(OC)c3c(c(-c4ccsc4)c2cc1OC)C(=O)OC3,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20050107354A1,CCOC(=O)COc1cc(-c2ccccc2S(C)(=O)=O)ccc1CCNS(=O)(=O)c1cc(C(=N)N)ccc1O.Cl>>CS(=O)(=O)c1ccccc1-c1ccc(CCNS(=O)(=O)c2cc(C(=N)N)ccc2O)c(OCC(=O)O)c1.Cl,,CC#N,,[Na+].[OH-],,val
US20080261946A1,CCOC(=O)C(F)(F)F.NC(=O)c1oc2ccc(Cl)cc2c1N>>O=c1[nH]c(C(F)(F)F)nc2c1oc1ccc(Cl)cc12,,CCO,,C,C[O-].[Na+],val
US20150225441A1,CC(=O)O[C@H]1[C@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)O[C@@](COCc2ccccc2)(C(F)F)[C@H]1OCc1ccccc1>>Nc1ncnc2c1ncn2[C@@H]1O[C@@](COCc2ccccc2)(C(F)F)[C@@H](OCc2ccccc2)[C@H]1O,,N,,CO,,val
US20100197908A1,CC(C)(C)OC(=O)N1CCc2ncc(CCc3ccc(OCc4ccccc4)nn3)cc2C1>>c1ccc(COc2ccc(CCc3cnc4c(c3)CNCC4)nn2)cc1,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20130156732A1,COC[C@H]1C[C@@H](c2nc3ccc4cc5c(cc4c3[nH]2)OCc2cc(B3OC(C)(C)C(C)(C)O3)ccc2-5)N(C(=O)OC(C)(C)C)C1>>COCC1CNC(c2nc3ccc4cc5c(cc4c3[nH]2)OCc2cc(B3OC(C)(C)C(C)(C)O3)ccc2-5)C1,,CCO,,Cl,,val
US20020177613A1,CC(N)C(C)(C)C.COc1ccc(-c2c(OC(C)C)c(=O)c2=O)cc1>>COc1ccc(-c2c(NC(C)C(C)(C)C)c(=O)c2=O)cc1,,CC#N,,,,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(Cl)c(OC)cc1CC2C>>COc1cc2c(cc1Cl)-c1cc(=O)c(C(=O)O)cn1C(C)C2,,CO,O,[Li]O,,val
US05378708,CC(N)c1ccc([Si](C)(C)C)cc1.CCc1ncnc(Cl)c1Cl>>CCc1ncnc(NC(C)c2ccc([Si](C)(C)C)cc2)c1Cl,,Cc1ccccc1,O,CCN(CC)CC,CCOCC,val
US20080280982A1,BrP(Br)Br.Cc1cc(CO)cc(C)c1-c1ccc(C(F)(F)F)cc1>>Cc1cc(CBr)cc(C)c1-c1ccc(C(F)(F)F)cc1,,C1CCOC1,,,,val
US20080280952A1,Nc1cc(F)ccc1Br.O=C(NCC1CCOCC1)c1cnc(Cl)cc1C1CC1>>O=C(NCC1CCOCC1)c1cnc(Nc2cc(F)ccc2Br)cc1C1CC1,,C1COCCO1,,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20090281060A1,CC(C)(C)OC(=O)N1CCC(S)CC1.CS(=O)(=O)OCc1nc(-c2ccncc2)no1>>CC(C)(C)OC(=O)N1CCC(SCc2nc(-c3ccncc3)no2)CC1,,C1CCOC1,CCOCC,CC(C)(C)[O-].[K+],,val
US06239131B1,Cc1ccc2c(c1)N(CC(=O)c1ccco1)C(=O)C(NC(=O)OC(C)(C)C)CN2C(=O)C(C)(C)C>>Cc1ccc2c(c1)N(CC(=O)c1ccco1)C(=O)C(N)CN2C(=O)C(C)(C)C,,CCO,,Cl,,val
US20160264554A1,COC(=O)CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N[C@H]2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)cc1>>CN(C/C=C/C(=O)Nc1ccc(C(=O)N[C@H]2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)cc1)CC(=O)O,,CO,,O,[Na+].[OH-],val
US20080096921A1,COC(=O)c1ccc2cc(-c3ccc(O)cc3)ccc2n1.OCc1c(-c2c(Cl)cccc2Cl)noc1C1CCC1>>COC(=O)c1ccc2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C4CCC4)cc3)ccc2n1,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05608056,Cn1ccnc1C=C[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OCc1ccccc1>>Cn1ccnc1C=C[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1,,CO,,Cl,C[O-].[Na+],val
US20110217311A1,O=C(OO)c1cccc(Cl)c1.O=[N+]([O-])c1ccc(F)cc1OC1CC=CC1>>O=[N+]([O-])c1ccc(F)cc1OC1CC2OC2C1,,ClCCl,,,,val
US05373002,CCOC(=O)/C=C/[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OC(C)(C)C.COCN(Cc1ccccc1)C[Si](C)(C)C>>CCOC(=O)C1CN(Cc2ccccc2)CC1[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OC(C)(C)C,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20090275590A1,CC(C)(C)OC(=O)N1CCc2[nH]c3cc(Br)ccc3c2C1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCc2c(c3ccc(Br)cc3n2C(=O)OC(C)(C)C)C1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20040224997A1,COC(=O)C(C)(C)CC(=O)c1ccc(-c2ccc([N+](=O)[O-])c(OC)c2)cc1>>COC(=O)C(C)(C)CC(=O)c1ccc(-c2ccc(N)c(OC)c2)cc1,[Fe],CCO,,Cl,,val
US05101048,CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@H](Sc2ccc(C#N)cc2C#N)SC[C@H]1OC(C)=O>>N#Cc1ccc(S[C@@H]2SC[C@@H](O)[C@H](O)[C@H]2O)c(C#N)c1,,CO,ClCCl,,,val
US20100178247A1,CC(C)(C)OC(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)[C@H](CCC(=O)O)NC(=O)N[C@@H](CCCCN)C(=O)OC(C)(C)C,[Pd],CCO,,O=C[O-].[NH4+],,val
US20040053957A1,CCCCCC(=O)CC(C)=O.N#CCC(N)=S>>CCCCCc1cc(C)c(C#N)c(S)n1,,CCO,,CCN(CC)CC,,val
US20030199544A1,CC(=O)N1CCc2[nH]nc(-c3cccc(Cl)c3)c2C1.CI>>CC(=O)N1CCc2c(c(-c3cccc(Cl)c3)nn2C)C1,,CN(C)C=O,O,[H-].[Na+],,val
US20090137557A1,Cc1nc(-c2ccccc2OCc2ccccc2)n(CCc2ccccc2)c(=O)c1-c1ccc(C#N)s1.[N-]=[N+]=[N-]>>Cc1nc(-c2ccccc2OCc2ccccc2)n(CCc2ccccc2)c(=O)c1-c1ccc(-c2nnn[nH]2)s1,,CCOC(C)=O,CN(C)C=O,[Cl-].[NH4+],,val
US20070254940A1,C1COCCN1.O=[N+]([O-])c1ccc2c(ccn2CCCCl)c1>>O=[N+]([O-])c1ccc2c(ccn2CCCN2CCOCC2)c1,,ClCCl,,[I-].[K+],,val
US07495007B2,C=C(C)C1NC(=O)CC(c2cc(Cl)ccc2[N+](=O)[O-])C12C(=O)Nc1cc(Cl)ccc12>>C=C(C)C1NC(=O)CC(c2cc(Cl)ccc2N)C12C(=O)Nc1cc(Cl)ccc12,[Ni],CO,,NN,O,val
US05536725,CC(C)(C)C(=O)Nc1nc2c(c(NC(=O)C(C)(C)C)n1)CC(=O)CC2.NOCc1cccc(C(F)(F)F)c1>>CC(C)(C)C(=O)Nc1nc2c(c(NC(=O)C(C)(C)C)n1)CC(=NOCc1cccc(C(F)(F)F)c1)CC2,,CCO,,CCN(CC)CC,Cl,val
US20150133510A1,O=[N+]([O-])c1ccc(CN(Cc2ccccc2)Cc2ccc([N+](=O)[O-])cc2)cc1>>Nc1ccc(CN(Cc2ccccc2)Cc2ccc(N)cc2)cc1,[Zn],CCO,,[Ca+2].[Cl-].[Cl-],,val
US20150158815A1,Cc1cccc(C(Nc2cncc(Br)c2)C(N)=O)c1.OB(O)c1cc(Cl)ccc1F>>Cc1cccc(C(Nc2cncc(-c3cc(Cl)ccc3F)c2)C(N)=O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20050143415A1,CC(C)(CC(O)(CO)CC1CCCCC1)c1ccccc1>>CC(C)(CC(O)(C=O)CC1CCCCC1)c1ccccc1,,CCN(CC)CC,,CS(C)=O,,val
US20160031871A1,CC(C)(C)OC(=O)N1CCC(Cc2ccc(C(F)(F)F)cc2)CC1.Cl>>Cl.FC(F)(F)c1ccc(CC2CCNCC2)cc1,,C1COCCO1,,,,val
US20060004069A1,CCC(=O)CBr.NC(=O)Cc1ccc([N+](=O)[O-])cc1>>CCc1coc(Cc2ccc([N+](=O)[O-])cc2)n1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070099990A1,CCOC(=O)CCc1ccc(C2COc3c(C)c(C)c(NC(=O)CC(C)(C)C)c(C)c32)cc1>>Cc1c(C)c2c(c(C)c1NC(=O)CC(C)(C)C)C(c1ccc(CCCO)cc1)CO2,,CCCCCC,CCOC(C)=O,,,val
US20130225554A1,Cn1nc(CO)c2c1C1CCC2C1.O=C1c2ccccc2C(=O)N1O>>Cn1nc(CON2C(=O)c3ccccc3C2=O)c2c1C1CCC2C1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06239131B1,Cc1ccc2c(c1)N(CC(=O)c1ccccc1C)C(=O)C(NC(=O)OC(C)(C)C)CN2C(=O)c1ccccn1>>Cc1ccc2c(c1)N(CC(=O)c1ccccc1C)C(=O)C(N)CN2C(=O)c1ccccn1,,C1COCCO1,Cl,,,val
US20080105851A1,Cc1cccc2[nH]cnc12.ClCc1ccccc1>>Cc1cccc2c1ncn2Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US03971806,O=C(O)C=CSc1c[nH]c2ccccc12>>O=c1ccsc2c1[nH]c1ccccc12,,CC(=O)O,,,,val
US20110263561A1,CC(C)(C)OC(=O)N1C[C@@H](F)C[C@@H]1COc1ccccc1Cl>>F[C@@H]1CN[C@@H](COc2ccccc2Cl)C1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20140086837A1,C[C@@H](NC(=O)c1c(F)cccc1[N+](=O)[O-])C(=O)O>>C[C@@H](NC(=O)c1c(N)cccc1F)C(=O)O,[Fe],CC(=O)O,,,,val
US20080188657A1,CC(C)c1nc(Cl)nc(-c2ccc(F)cc2)c1Br.CNS(C)(=O)=O>>CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1Br,,CCCCCC,CN(C)C=O,[H-].[Na+],,val
US05006563,CN(C)c1cccc(O)c1.O=C(CBr)c1cccc(Cl)c1>>CN(C)c1cccc(OCC(=O)c2cccc(Cl)c2)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04330321,CC(C)N=C=O.CC(Oc1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1)C(N)=O>>CC(C)NC(=O)NC(=O)C(C)Oc1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1,,Cc1ccccc1,,,,val
US20060161001A1,COC(=O)[C@@H](Cc1ccccc1)Nc1nccc(N2CCCc3cnc(-c4ccccc4)cc32)n1.N>>NC(=O)[C@@H](Cc1ccccc1)Nc1nccc(N2CCCc3cnc(-c4ccccc4)cc32)n1,,CO,,[NH4+].[OH-],,val
US06191281B1,CN(CCCN1C(=O)CS[C@H]1c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)CCOc1ccc2c(c1)OCO2.O=C(O)/C=C/C(=O)O>>CN(CCCN1C(=O)CS[C@H]1c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)CCOc1ccc2c(c1)OCO2.O=C(O)/C=C/C(=O)O,,CCOC(C)=O,CO,,,val
US20030087936A1,Clc1ccc(OCCCCCCCBr)cc1.O=C1NCCN1c1ccncc1>>O=C1N(CCCCCCCOc2ccc(Cl)cc2)CCN1c1ccncc1,,CN(C)C=O,,[H-].[Na+],,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(O)cc(C)c21.NC(=O)c1nnc(Cl)s1>>CCOC(=O)CC1OB(O)c2cc(Oc3nnc(C(N)=O)s3)cc(C)c21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160095858A1,COc1ccc2c(c1)C(C)(C(=O)NS(=O)(=O)c1cccc([N+](=O)[O-])n1)N(Cc1c(C)cc(C)cc1C)C2>>Cc1cc(C)c(CN2Cc3ccc(O)cc3C2(C)C(=O)NS(=O)(=O)c2cccc([N+](=O)[O-])n2)c(C)c1,,ClCCl,,BrB(Br)Br,,val
US20060030590A1,CCC(=O)Nc1cc(F)ccc1NC1CCN(Cc2ccccc2)CC1>>CCc1nc2cc(F)ccc2n1C1CCN(Cc2ccccc2)CC1,,CC(=O)O,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US05395946,CC(C)(C)N.O=C(Cl)CCCCl>>CC(C)(C)NC(=O)CCCCl,,CCOCC,,CCN(CC)CC,O,val
US04668693,CCO.ClCn1c(Br)nc(Cl)c1Cl>>CCOCn1c(Br)nc(Cl)c1Cl,,CCO,,C,C[O-].[Na+],val
US20160207930A1,C=CCC1(CC=C)C[C@H]2[C@H](c3cccc(C)c3C)NCCN2C1=O.CN[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C=CCC1(CC=C)C[C@H]2[C@H](c3cccc(C)c3C)N(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CCN2C1=O,CN(C)c1ccncc1,CCOC(C)=O,,,,val
US20070208033A1,CCCN(CCC)c1ccc(NC(=O)c2ccc(CNCc3ncc[nH]3)cc2)cc1.CCCn1ccnc1C=O.CO>>CCCN(CCC)Cc1ccc(NC(=O)c2ccc(CN(Cc3ncc[nH]3)Cc3nccn3CCC)cc2)cc1,,CC(=O)O,CO,[Na+].[OH-],,val
US20080132546A1,CCCCN.CCOC(=O)/C(=C\N(C)C)C(=O)c1cc(I)ccc1F>>CCCCn1cc(C(=O)OCC)c(=O)c2cc(I)ccc21,,CCO,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06127354,CN(CCc1ccccc1NC(=O)CNC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)OC(C)(C)C>>CN[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1NC(=O)CNC(=O)OCC1c2ccccc2-c2ccccc21,,CCOC(C)=O,Cl,,,val
US07928107B2,Cc1ccc2c(N3CCC(N)CC3)nc(-c3ccccc3O)nc2c1.O=C(O)[C@H]1CCCO1>>Cc1ccc2c(N3CCC(NC(=O)[C@H]4CCCO4)CC3)nc(-c3ccccc3O)nc2c1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04816063,C#CCBr.O=c1sc(=Nc2ccc(Cl)c(O)c2F)n2n1CCCC2>>C#CCOc1c(Cl)ccc(N=c2sc(=O)n3n2CCCC3)c1F,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040043987A1,O=[N+]([O-])c1ccc2c(c1)S(=O)(=O)NC(C1CCCCC1)=N2>>Nc1ccc2c(c1)S(=O)(=O)NC(C1CCCCC1)=N2,[Pd],[Na+],[OH-],CCO,,val
US20090181928A1,C=CC(C)(C)NC(=O)OC(C)(C)C.C[Si](C)(C)CCN1C(=O)CN(c2ccc(I)cc2OCc2ccccc2)S1(=O)=O>>CC(C)(/C=C/c1ccc(N2CC(=O)N(CC[Si](C)(C)C)S2(=O)=O)c(OCc2ccccc2)c1)NC(=O)OC(C)(C)C,,CN(C)C=O,,CCN(CC)CC,,val
US20050192276A1,CC(C)(C)OC(=O)N1CC2CC(N3CCC(NC(=O)OCc4ccccc4)C3=O)C(CO)C2C1.c1ccc(SSc2ccccc2)cc1>>CC(C)(C)OC(=O)N1CC2CC(N3CCC(NC(=O)OCc4ccccc4)C3=O)C(CSc3ccccc3)C2C1,,C1CCOC1,,CCCCP(CCCC)CCCC,,val
US20070129355A1,COC(=O)Cc1c(N(C)C)nc(Cc2ccc([N+](=O)[O-])cc2)nc1N(C)C>>COC(=O)Cc1c(N(C)C)nc(Cc2ccc(N)cc2)nc1N(C)C,[Pd],CO,,[H][H],,val
US20020143046A1,COC(=O)/C=C(/C)N.COC(=O)C(=Cc1ccccc1Cl)C(=O)COCCN1C(=O)c2ccccc2C1=O>>COC(=O)C1=C(C)NC(COCCN2C(=O)c3ccccc3C2=O)=C(C(=O)OC)C1c1ccccc1Cl,,CC(C)O,,,,val
US20080275043A1,Nc1ccc(Cl)c(CC2CCN(C3CCCCC3)C2=O)c1Cl.O=C1CCC(=O)N1Br>>Nc1c(Br)cc(Cl)c(CC2CCN(C3CCCCC3)C2=O)c1Cl,,ClC(Cl)(Cl)Cl,,,,val
US05556864,CCOC(=O)C=Cc1ccc2ccccc2c1>>CCOC(=O)CCc1ccc2ccccc2c1,[Pd],CCO,,[H][H],,val
US06002008,COc1cc2ncc(C#N)c(Cl)c2cc1OC.Cc1ccc(O)c(N)c1>>COc1cc2ncc(C#N)c(Nc3cc(C)ccc3O)c2cc1OC,,CCOCCO,,Cl,c1ccncc1,val
US04273704,COC(=O)C12CC3CC(CC(N)(C3)C1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C2.Cl>>COC(=O)C12CC3CC(CC(N)(C3)C1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CCSC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C2.Cl,,C1COCCO1,,CC(=O)O,,val
US05602161,CC(C)(C)C(=O)Oc1ccc(-c2nnn(Cc3ccccc3N)n2)cc1.CS(=O)(=O)Cl>>CC(C)(C)C(=O)Oc1ccc(-c2nnn(Cc3ccccc3NS(C)(=O)=O)n2)cc1,,ClCCl,,c1ccncc1,,val
US20050222096A1,O=C(N[C@H](CO)Cc1ccccc1)c1cc(OCc2ccccc2)ccc1O>>O=C(N[C@H](CO)Cc1ccccc1)c1cc(O)ccc1O,,CO,,,,val
US20100144731A1,COC(=O)C1(c2ccc(N)cc2)CCCC1.Clc1nc(CC2CCCC2)nc2c1CCC2>>COC(=O)C1(c2ccc(Nc3nc(CC4CCCC4)nc4c3CCC4)cc2)CCCC1,,CC(C)O,,,,val
US20060193926A1,CCB(CC)c1cccnc1.Ic1cccc(I)c1>>Ic1cccc(-c2cccnc2)c1,,O,,CN(C)C=O,,val
US06080754,CCCC(=O)CC(=O)OCC.N>>CCCC(N)=CC(=O)OCC,,CCOCC,,O=S(=O)([O-])[O-].[Mg+2],,val
US04874894,COc1ccccc1.O=P(Cl)(Cl)Cl.O=S(=O)(O)O>>COc1ccc(S(=O)(=O)Cl)cc1,,O,,[Cl-].[Na+],,val
US20100278833A1,COC(=O)c1sc(-n2cnc3cnccc32)cc1OCc1ccccc1F.N>>NC(=O)c1sc(-n2cnc3cnccc32)cc1OCc1ccccc1F,,CO,,,,val
US20150080362A1,CCc1c(O)c(C(=O)OC)c(=O)n(Cc2ccc(OC)cc2OC)c1-c1ccc(N(C)C)s1>>CCc1c(-c2ccc(N(C)C)s2)[nH]c(=O)c(C(=O)OC)c1O,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20080188528A1,Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](N)C(=O)OC(C)(C)C)c(C)c2c1OC(C)(C)CC2.Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)O)c1>>Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)N[C@@H](CCCNC(=N)NS(=O)(=O)c2c(C)c(C)c3c(c2C)CCC(C)(C)O3)C(=O)OC(C)(C)C)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060264415A1,BrCCc1c[nH]c2ccccc12.O=C(COCc1ccc(F)cc1)NCCC1CCNCC1>>O=C(COCc1ccc(F)cc1)NCCC1CCN(CCc2c[nH]c3ccccc23)CC1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20160207926A1,NCC(F)(F)F.O=[N+]([O-])c1c(Cl)ncnc1Cl>>O=[N+]([O-])c1c(Cl)ncnc1NCC(F)(F)F,,C1CCOC1,,,,val
US20070060558A1,CCOC(=O)/C(=N\OCCNc1ccnc2cc(Cl)ccc12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>O=C(O)/C(=N\OCCNc1ccnc2cc(Cl)ccc12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,C1COCCO1,,[Na+].[OH-],,val
US20090142297A1,COC(=O)CC(=O)OC.O=[N+]([O-])c1ccc(Cl)nc1>>COC(=O)C(C(=O)OC)c1ccc([N+](=O)[O-])cn1,,CN(C)C=O,,[H-].[Na+],,val
US20130115190A1,CC1CCC=C[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2(CF)CC2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)OC(C)(C)C)[C@H](C)C1.COc1ccc2c(Cl)cc(-c3ccc(OC(C)C)cc3)nc2c1>>COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6(CF)CC6)C[C@H]5C=CCCC(C)C[C@@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N4C3)cc(-c3ccc(OC(C)C)cc3)nc2c1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20050182139A1,CC(C)(C)OC(=O)N1[C@H](CF)[C@@H](c2ccc(S(=O)(=O)CF)cc2)OC1(C)C>>N[C@H](CF)[C@H](O)c1ccc(S(=O)(=O)CF)cc1,,CO,,Cl,,val
US20050182040A1,BrCCCCBr.CCCN[C@@H]1CC[C@@H](Nc2cc(OC)c(C(N)=O)cc2Cl)CC1>>COc1cc(N[C@@H]2CC[C@@H](N3CCCC3)CC2)c(Cl)cc1C#N,,CN(C)C=O,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US03984555,CC=Cc1nc2ccc(C)cc2c(=O)[nH]1.O=C1CCC(=O)N1Br>>Cc1ccc2nc(C=CCBr)[nH]c(=O)c2c1,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US05773388,CC(C)(C)C(=O)c1cncnc1-c1ccc(Cl)cc1>>CC(C)(C)C(O)c1cncnc1-c1ccc(Cl)cc1,,CCO,,,,val
US20150065705A1,CCN(CC)S(F)(F)F.O=c1nc(N2CC=C(c3ccc(F)cc3)C(O)C2)ncn1Cc1ccc(Cl)cc1>>O=c1nc(N2CC=C(c3ccc(F)cc3)C(F)C2)ncn1Cc1ccc(Cl)cc1,,ClCCl,,,,val
US04912105,CC(CN1CCCC1)N1c2ccccc2Sc2ccc(C(=N)N)cc21.CI.Cl>>CC(C[N+]1(C)CCCC1)N1c2ccccc2Sc2ccc(C(=N)N)cc21.Cl.[I-],,CN(C)C=O,,CC(C)OC(C)C,,val
US04550103,CC(C)N.O=C(O)C1CC(=O)N(Cc2ccccc2)C1>>CC(C)NC(=O)C1CC(=O)N(Cc2ccccc2)C1,,CC#N,,O=C(n1ccnc1)n1ccnc1,,val
US20150344480A1,CN(N)C(=S)N1CCN(C(=O)OC(C)(C)C)CC1.O=C(CBr)c1ccc(F)cc1>>Cn1nc(-c2ccc(F)cc2)cc1N1CCNCC1,,CCO,,Cl,,val
US20070249670A1,COc1ccc(-c2ccc(C(=O)N[C@H](C(=O)OC(C)(C)C)C3CCCCC3)c(NC(=O)Nc3c(Cl)cc(OC(F)(F)F)cc3Cl)c2)cc1>>COc1ccc(-c2ccc(C(=O)N[C@H](C(=O)O)C3CCCCC3)c(NC(=O)Nc3c(Cl)cc(OC(F)(F)F)cc3Cl)c2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150141406A1,CCOC(=O)COc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.COc1ncc(Cl)c2c1c(OS(=O)(=O)C(F)(F)F)nn2-c1c(F)cccc1F>>COc1ncc(Cl)c2c1c(-c1ccc(OCC(=O)O)cc1)nn2-c1c(F)cccc1F,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110135650A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.O=C1NCc2cc(I)ccc21>>CC(C)(C)[Si](c1ccccc1)(c1ccccc1)N1Cc2cc(I)ccc2C1=O,,CN(C)C=O,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20100093757A1,COCC(OC(C)=O)C(=O)Nc1ccc(C)cn1>>COCC(O)C(=O)Nc1ccc(C)cn1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20140080808A1,Brc1cncc(Br)c1.CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(C3(c4ccc(B5OC(C)(C)C(C)(C)O5)cc4)CC3)n2CCS1>>CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(C3(c4ccc(-c5cncc(Br)c5)cc4)CC3)n2CCS1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20060287291A1,ClCCl.Nc1cc(NCCN2CCOCC2)c2occc2c1.O=S(=O)(Cl)c1ccccc1>>Cl.O=S(=O)(Nc1cc(NCCN2CCOCC2)c2occc2c1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20040242879A1,CI.O=C1NCCN(Cc2ccccc2)C1c1ccccc1>>CN1CCN(Cc2ccccc2)C(c2ccccc2)C1=O,,CN(C)C=O,O,[H-].[Na+],,val
US20070155727A1,COC(=O)c1ccc(CN(C)CC2(CN(C)CC(=O)Nc3ccc(Oc4ccccc4)cc3)CCCC2)cc1>>CN(CC(=O)Nc1ccc(Oc2ccccc2)cc1)CC1(CN(C)Cc2ccc(C(=O)O)cc2)CCCC1,,C1CCOC1,CO,[Na+].[OH-],,val
US08198448B2,COc1ccc2c(OCc3nnc4ccc(-c5ccc(N(C)C(=O)OC(C)(C)C)cc5)cn34)ccnc2c1>>CNc1ccc(-c2ccc3nnc(COc4ccnc5cc(OC)ccc45)n3c2)cc1,,CO,,CCN(CC)CC,Cl,val
US04698340,CC(=O)CC(C)=O.O=Cc1ccc(O)c([N+](=O)[O-])c1>>CC(=O)CC(=O)C=Cc1ccc(O)c([N+](=O)[O-])c1,,CCOCC,c1ccccc1,C1CCNCC1,CC(=O)O,val
US20110319378A1,COC(=O)C[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N([C@H](CO)C2CC2)C1=O.NS(=O)(=O)c1cccs1>>COC(=O)C[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N([C@H](CNS(=O)(=O)c2cccs2)C2CC2)C1=O,,Cc1ccccc1,,CCCCP(=CC#N)(CCCC)CCCC,,val
US20120309966A1,Cc1nccn2c(N3CCN(C(=O)OCc4ccccc4)CC3)ncc12.Cl>>Cc1nccn2c(N3CCNCC3)ncc12.Cl,,O,,,,val
US20030236287A1,COc1ccc(NC(C)=O)cc1F.O=[N+]([O-])O>>COc1cc([N+](=O)[O-])c(NC(C)=O)cc1F,,O=S(=O)(O)O,,,,val
US20120220453A1,CC(C)OB1OC(C)(C)C(C)(C)O1.Cc1nn(-c2cncc(F)c2)cc1I>>Cc1nn(-c2cncc(F)c2)cc1B1OC(C)(C)C(C)(C)O1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20160052922A1,CN.Cc1nn(C(C)C)c2nc(-c3cccc(OCC4CO4)c3)c(C(=O)N(C)C)c(NC3CCOCC3)c12>>CNCC(O)COc1cccc(-c2nc3c(c(C)nn3C(C)C)c(NC3CCOCC3)c2C(=O)N(C)C)c1,,CO,,,,val
US20150038437A1,CCc1cc(C(=O)OC)c(OC)nc1-c1ccc2nc(CO[Si](C)(C)C(C)(C)C)cn2c1>>CCc1cc(C(=O)OC)c(OC)nc1-c1ccc2nc(CO)cn2c1,,CO,,Cl,,val
US20070072865A1,CC(C)(C)OC(=O)N1CCNC(C(O)(c2ccccc2)c2ccccc2)C1.O=C(Cl)CCl>>CC(C)(C)OC(=O)N1CCN(C(=O)CCl)C(C(O)(c2ccccc2)c2ccccc2)C1,,C1CCOC1,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20080015199A1,COc1cc(C=O)c(F)c2c1OCCO2.C[Si](C)(C)C#N.Cc1nc(-c2ccc(N)cc2)no1>>COc1cc(C(C#N)Nc2ccc(-c3noc(C)n3)cc2)c(F)c2c1OCCO2,,C1CCOC1,,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US04954507,CC(C)(C)N.CCOC=C(C(=O)OCC)C(=O)c1cc(F)c(F)cc1F>>CCOC(=O)C(=CNC(C)(C)C)C(=O)c1cc(F)c(F)cc1F,,CCO,,,,val
US20120190665A1,CN(C)C=C(C(=O)c1cccc(Cl)c1)N1C(=O)c2ccccc2C1=O.NN>>Nc1c[nH]nc1-c1cccc(Cl)c1,,CCO,,,,val
US20010027196A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.CSc1nc(N)nc(Br)c1C#N>>C=C(OCC)c1nc(N)nc(SC)c1C#N,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,,,val
US20080139631A1,O=C(O)c1cccc(C(F)(F)F)n1.[H]/N=C(/Cn1c(C)cc2c(C(F)(F)F)c(C#N)ccc21)NO>>Cc1cc2c(C(F)(F)F)c(C#N)ccc2n1Cc1noc(-c2cccc(C(F)(F)F)n2)n1,,CC#N,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120245344A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.O=C(OCc1ccccc1)c1ccc(Br)cn1>>CC(C)(C)OC(=O)N1CC=C(c2ccc(C(=O)OCc3ccccc3)nc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20060025404A1,CC(C)(C)OC(=O)N1CCCN(Cc2ccc(OCCCN3CCCCC3)cc2)CC1>>c1cc(OCCCN2CCCCC2)ccc1CN1CCCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120309754A1,CCOC(=O)CC(=O)O.Cc1nc2ccc(F)cc2nc1-c1cc(N)[nH]n1>>CCOC(=O)CC(=O)Nc1cc(-c2nc3cc(F)ccc3nc2C)n[nH]1,,c1ccncc1,,CCN=C=NCCCN(C)C,Cl,val
US20120258973A1,CC(=O)C1CCCC1.C[C@@H](N)c1ccccc1>>CC(=N[C@H](C)c1ccccc1)C1CCCC1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,CCN(CC)CC,CCOCC,val
US20130023526A1,COC(=O)c1cc(O)nc(C)n1.O=P(Br)(Br)Br>>COC(=O)c1cc(Br)nc(C)n1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20080064676A1,CC(C)(C)OC(=O)NCCC[C@@H](NC(=O)OCc1ccccc1)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NCCC[C@@H](N)C(=O)OC(C)(C)C,[Pd],CCO,,,,val
US20160052898A1,O=C(Cl)C(=O)Cl.O=C(O)c1ccc(C(F)(F)F)c([N+](=O)[O-])c1>>O=C(Cl)c1ccc(C(F)(F)F)c([N+](=O)[O-])c1,CN(C)C=O,ClCCl,,,,val
US20080039459A1,COCC(=O)Cl.Nc1cccc(-c2cc3nc(Cl)nc(N4CCOCC4)c3s2)c1>>COCC(=O)Nc1cccc(-c2cc3nc(Cl)nc(N4CCOCC4)c3s2)c1,,ClCCl,,CCN(CC)CC,,val
US20090124665A1,CC(O)CNC(=O)CC(c1ccccc1)C(C(=O)N(C(C)C)C(C)C)c1cccnc1>>CC(=O)CNC(=O)CC(c1ccccc1)C(C(=O)N(C(C)C)C(C)C)c1cccnc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20130345227A1,O=P(Cl)(Cl)Cl.O=c1[nH]ccc2cnccc12>>Clc1nccc2cnccc12,,Clc1ccccc1,,,,val
US20080293696A1,CS(=O)(=O)Cl.NC(=O)c1cc(CO)ccn1>>CS(=O)(=O)OCc1ccnc(C(N)=O)c1,,CCOC(C)=O,,CCN(CC)CC,,val
US20130324501A1,COC(=O)c1sccc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1>>CN(C)C(=O)c1cccc(S(=O)(=O)Nc2ccsc2C(=O)O)c1,,Cl,,CO,[Na+].[OH-],val
US20100249176A1,CI.C[C@@H](NC(=O)Cc1ccc2cc[nH]c2c1)c1ccc(OCC(F)(F)F)cn1>>Cc1c[nH]c2cc(CC(=O)N[C@H](C)c3ccc(OCC(F)(F)F)cn3)ccc12,,C1CCOC1,,CC[Mg]Br,,val
US06248740B1,CCOC(=O)C(C)(C)c1cn2nc(Cl)ccc2n1.O=C1CCC(=O)N1Cl>>CCOC(=O)C(C)(C)c1nc2ccc(Cl)nn2c1Cl,,CCOC(C)=O,,O,,val
US20090247571A1,CCC(CC)Nc1nc(N(C)C)ccc1[N+](=O)[O-].O=C(n1ccnc1)n1ccnc1>>CCC(CC)n1c(O)nc2ccc(N(C)C)nc21,[Pd],CO,,,,val
US20070124152A1,CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN2C(=O)c3ccccc3C2=O)c1=O.NCCN1CCOCC1>>O=C(NCCN1CCOCC1)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN2C(=O)c3ccccc3C2=O)c1=O,,CCO,,,,val
US20140343000A1,C=C(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.C=CC(=O)OC>>C=C(C)[C@@H]1CC[C@]2(NCCC(=O)OC)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,CCO,,CCN(CC)CC,,val
US20060235032A1,COC(=O)CC1c2cccc(F)c2N=C(c2ccc(Br)cc2)N1c1cc(C(F)(F)F)ccc1OC.OB(O)c1cccc(F)c1>>COC(=O)CC1c2cccc(F)c2N=C(c2ccc(-c3cccc(F)c3)cc2)N1c1cc(C(F)(F)F)ccc1OC,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20070232583A1,Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(-n2cnc(-c3ccc(S(=O)(=O)NC(C)(C)C)s3)c2)n1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(-n2cnc(-c3ccc(S(N)(=O)=O)s3)c2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150080393A1,CCOC(=O)C(F)(F)F.Fc1ccc(Br)cc1>>O=C(c1cc(Br)ccc1F)C(F)(F)F,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20070123561A1,CC(C)(C)OC(=O)Nc1ccc(Nc2ccncc2[N+](=O)[O-])cc1>>CC(C)(C)OC(=O)Nc1ccc(Nc2ccncc2N)cc1,[Pd],CCO,,,,val
US20090131458A1,BrCC1CCOCC1.CCCCCNc1nc(N)c2nc(OC)[nH]c2n1>>CCCCCNc1nc(N)c2nc(OC)n(CC3CCOCC3)c2n1,,CCOC(C)=O,CN(C)C=O,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20060173019A1,COCN(c1cc(Cl)c(C)nc1C(=O)c1ccccc1S(C)(=O)=O)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>Cc1nc(C(=O)c2ccccc2S(C)(=O)=O)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl,,C1COCCO1,Cl,O,,val
US20080064715A1,OC(c1ccccc1)c1cc2ccnc(Cl)c2[nH]1>>O=C(c1ccccc1)c1cc2ccnc(Cl)c2[nH]1,O=[Mn]=O,ClCCl,,,,val
US20140221341A1,CCCC(=O)NNC(=O)[C@H]1CC[C@H]2CN1C(=O)N2OCc1ccccc1>>CCCC(=O)NNC(=O)[C@H]1CC[C@H]2CN1C(=O)N2O,[Pd],CO,,[H][H],,val
US06136823,CCOC(=O)c1cn(-c2ccc(F)c(OC)c2)c2c(C)c(F)c(F)cc2c1=O>>Cc1c(F)c(F)cc2c(=O)c(C(=O)O)cn(-c3ccc(F)c(O)c3)c12,,CC(=O)O,,Br,,val
US20020025301A1,O=c1cc(C=Cc2ccccc2)oc2cccc(OCc3ccccc3)c12>>O=c1cc(C=Cc2ccccc2)oc2cccc(O)c12,,ClCCl,,BrB(Br)Br,,val
US05677305,CN(C)S(=O)(=O)c1cc([N+](=O)[O-])c(N)cc1-n1ccc(=O)cc1>>CN(C)S(=O)(=O)c1cc(N)c(N)cc1-n1ccc(=O)cc1,[Fe],CCO,,Cl,O,val
US20100029650A1,Cc1cc(S(C)(=O)=O)ccc1-c1ccc(OCC2CCN(C(=O)OC(C)(C)C)CC2)cn1.O=C(O)C(F)(F)F>>Cc1cc(S(C)(=O)=O)ccc1-c1ccc(OCC2CCNCC2)cn1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05665747,CC(=O)c1sc(C)nc1C.Cc1csc([Si](C)(C)C)n1>>Cc1csc(C(C)(O)c2sc(C)nc2C)n1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20030114666A1,C[C@@H](c1ccccc1)N1CCC(C(NC(=O)OC(C)(C)C)c2ccccc2F)C1.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)NC(c1ccccc1F)C1CCN(C(=O)OCc2ccccc2)C1,,ClCCl,,,,val
US20020016368A1,CCOC(=O)Cc1cccc(CN(Cc2cccc3c2OCCO3)S(C)(=O)=O)c1>>CS(=O)(=O)N(Cc1cccc(CC(=O)O)c1)Cc1cccc2c1OCCO2,,CO,Cl,[Na+].[OH-],,val
US06972297B2,COC(=O)c1cnc(OC)nc1>>COc1ncc(C(=O)O)cn1,,C1COCCO1,,O,[Na+].[OH-],val
US20060163536A1,C#CC(C)(C)O.Fc1ccc(Br)c(F)c1F>>CC(C)(O)C#Cc1ccc(F)c(F)c1F,I[Cu]I,CCN(CC)CC,CN(C)C=O,Cl,O,val
US20020028835A1,COc1ccc(C(=O)Nc2ccc(N3CCC(=O)CC3)cc2)cc1OC.NC[C@H](O)COc1cccc2[nH]c(=O)[nH]c12>>COc1ccc(C(=O)Nc2ccc(N3CCC(NC[C@H](O)COc4cccc5[nH]c(=O)[nH]c45)CC3)cc2)cc1OC,,CN(C)C=O,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20090124629A1,C=CCCCC(=NC)NC.NNC(=O)c1ccccc1>>C=CCCCc1nnc(-c2ccccc2)n1C,,CO,,Cl,O=C([O-])[O-].[K+].[K+],val
US06884821B1,Brc1ccccc1.COC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1Cl>>COC(=O)c1ccc(-c2ccccc2)cc1Cl,,COCCOC,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20110294781A1,C1COCCN1.Clc1cccc(-c2cc3nc(Cl)cc(Cl)n3n2)c1>>Clc1cccc(-c2cc3nc(Cl)cc(N4CCOCC4)n3n2)c1,,C1COCCO1,,,,val
US20110152295A1,CCCC[Sn](CCCC)(CCCC)c1cn(Cc2cc(Cl)c(Cl)c(Cl)c2)nn1.II>>Clc1cc(Cn2cc(I)nn2)cc(Cl)c1Cl,,C1CCOC1,,,,val
US20070208005A1,Brc1ccc(Cc2ccc3c(c2)CCN(C2CCC2)CC3)cn1.O=C1NCCO1>>O=C1OCCN1c1ccc(Cc2ccc3c(c2)CCN(C2CCC2)CC3)cn1,[Cu]I,C1COCCO1,CO,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US20160264567A1,O=C1NC(=O)c2ccccc21.OCc1cc(Br)ccc1F>>O=C1c2ccccc2C(=O)N1Cc1cc(Br)ccc1F,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150119254A1,C#CCCCCCCC(O)CO>>C#CCCCCCCC=O,,CC(C)=O,O,,,val
US20100197619A1,C1CCNCC1.C=O.COc1c(O)cc(O)c2c(=O)cc(-c3ccccc3)oc12>>COc1c(O)c(CN2CCCCC2)c(O)c2c(=O)cc(-c3ccccc3)oc12,,CO,,,,val
US20110201657A1,C=O.NC(=O)c1cc(F)cc2cn(C3CC[NH2+]C3)nc12.O=C([O-])C(F)(F)F>>C[NH+]1CCC(n2cc3cc(F)cc(C(N)=O)c3n2)C1.O=C([O-])C(F)(F)F,,CO,,CC(=O)O,,val
US20120309796A1,CC(C)(C)OC(=O)COc1cccc2c1CCCCC2NS(=O)(=O)c1ccc(I)cc1.Cc1cc(B(O)O)cc(C(C)(C)C)c1>>Cc1cc(-c2ccc(S(=O)(=O)NC3CCCCc4c(OCC(=O)OC(C)(C)C)cccc43)cc2)cc(C(C)(C)C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20060183732A1,COC(=O)OC/C=C/c1ccccc1.NCc1ccccc1>>C=C[C@H](NCc1ccccc1)c1ccccc1,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150274656A1,CNC(=O)C[C@@H]1[C@@H](O)[C@@H]2O[Si](C(C)C)(C(C)C)O[Si](C(C)C)(C(C)C)OC[C@H]2N1C(=O)OC(C)(C)C>>CNC(=O)C[C@@H]1C(=O)[C@@H]2O[Si](C(C)C)(C(C)C)O[Si](C(C)C)(C(C)C)OC[C@H]2N1C(=O)OC(C)(C)C,,CCOCC,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20110300165A1,Cc1ccc(C#N)c(C(F)(F)F)c1.NO>>Cc1ccc(C(N)=NO)c(C(F)(F)F)c1,,CO,,Cl,O=C([O-])O.[Na+],val
US20030099785A1,CCCCCCCCBr.Oc1ccc(-c2ccc(Br)cc2)cc1>>CCCCCCCCOc1ccc(-c2ccc(Br)cc2)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150148311A1,COc1c(Cl)ccc(Cl)c1C(=O)O>>COc1c(Cl)ccc(Cl)c1CO,,C1CCOC1,,,,val
US04526608,CN(O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-].COCCOCBr>>COCCOCON(C)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],,ClCCl,,CCN(C(C)C)C(C)C,,val
US04001226,COC(=O)C1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)Cc3cccs3)[C@H]2SC1N.O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)C(C(=O)O)=CS[C@H]12.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COC(=O)NC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)Cc3cccs3)[C@H]2SC1,,CCO,ClC(Cl)Cl,CCN(CC)CC,,val
US20090197871A1,CC(C)(C)OC(=O)N1CCN(Cc2cccc(B(O)O)c2)CC1.NCc1ccc(F)c(Br)c1>>CC(C)(C)OC(=O)N1CCN(Cc2cccc(-c3cc(CN)ccc3F)c2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20020193596A1,COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(N)cc1-c1cccc2ccccc12.O=Cc1ccncc1>>COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NCc2ccncc2)cc1-c1cccc2ccccc12,,CO,,,,val
US20110028492A1,Fc1cccc(CNc2cccc(-c3cc(F)ncc3Cl)n2)c1.N[C@@H]1CC[C@H](O)C1>>O[C@H]1CC[C@@H](Nc2cc(-c3cccc(NCc4cccc(F)c4)n3)c(Cl)cn2)C1,,CN1CCCC1=O,,CCN(CC)CC,,val
US04374984,CC(C)(O)C(=O)C1=CC=C2C(=Cc3cc(C(=O)C(C)(C)O)ccc32)C1=O.C[Si](C)(C)C(C(N)=O)[Si](C)(C)C>>CC(C)(O[Si](C)(C)C)C(=O)C1=CC=C2C(=Cc3cc(C(=O)C(C)(C)O[Si](C)(C)C)ccc32)C1=O,,c1ccncc1,,Cc1ccccc1,,val
US04663344,O=C(O)C(Br)c1ccccc1.O=C(O)c1c(O)cccc1S>>O=C(O)c1c(O)cccc1SC(C(=O)O)c1ccccc1,,[Na+],[OH-],Cl,,val
US05286740,CC(CC(F)(F)F)C(N)=O.Cl>>CC(CN)CC(F)(F)F.Cl,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050222225A1,O=C1CCC(=O)N1Cl.c1cc2cc(C3OCCO3)ccc2o1>>Clc1cc2cc(C3OCCO3)ccc2o1,,C1CCOC1,CCOC(C)=O,O,[Li]CCCC,val
US04963568,COC(=O)[C@@H]1CCc2cc(OC)c(OC)c3c2[C@@H]1C[C@H](c1ccccc1)C3>>COc1cc2c3c(c1OC)C[C@@H](c1ccccc1)C[C@@H]3[C@H](C(=O)O)CC2,,CO,,[Na+].[OH-],,val
US20040038990A1,CC(N)=NC(=S)Nc1cccc(C#N)c1.O=C(CBr)c1ccccc1C(F)(F)F>>Cc1nc(Nc2cccc(C#N)c2)sc1C(=O)c1ccccc1C(F)(F)F,,CCO,CO,CCN(CC)CC,,val
US03937726,Cc1ccc(S(=O)(=O)OCCCl)cc1.O=[N+]([O-])c1ccc(O)cc1>>Nc1ccc(OCCCl)cc1,,O,,[Na+].[OH-],,val
US20090192163A1,C1COCCN1.O=S(=O)(Cl)c1ccc(F)c(Cl)c1>>O=S(=O)(c1ccc(F)c(Cl)c1)N1CCOCC1,,ClCCl,,,,val
US20040235854A1,CCOC(=O)c1nc(-c2ccc(Cl)cc2)n(-c2ccc(Cl)cc2Cl)c1C.O=S(Cl)Cl>>Cc1c(C(=O)Cl)nc(-c2ccc(Cl)cc2)n1-c1ccc(Cl)cc1Cl,,C1CCOC1,O,[Li+].[OH-],,val
US20070191333A1,C=CC#N.Cc1c(N2CC(F)C(CN)C2)c(F)cc2c(=O)n(N)c(=O)n(C3CC3)c12>>Cc1c(N2CC(F)C(CNCCC#N)C2)c(F)cc2c(=O)n(N)c(=O)n(C3CC3)c12,,CO,,CCN(CC)CC,,val
US06576247B1,C=CCc1ccc(O)c(OC)c1.CC(=O)OC[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H](C=O)OC(C)=O>>C=CCc1ccc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(OC)c1,,Cc1ccccc1,,,,val
US05489593,CCOC(=O)C1=CC2=C(C)C(C)(OC)C=C(C)C2=N1>>COc1c(C)c(C)c2[nH]c(C(=O)O)cc2c1C,,CCO,,CC(=O)O,[K+].[OH-],val
US20040019051A1,CC(C)(C)[Si](C)(C)OCC1COc2cc(Br)cnc2O1.CI>>Cc1cnc2c(c1)OCC(CO[Si](C)(C)C(C)(C)C)O2,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20160102107A1,COc1ncccc1C(=O)C1C(=O)C(c2ccc(Cl)cc2)N(c2cc(C)c3nnc(C)n3c2)C1=O.NN>>COc1ncccc1-c1n[nH]c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1,,CO,ClCCl,,,val
US20130045942A1,C[C@@H](N)c1ccc(Cl)cc1.OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O>>C[C@@H](Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1ccc(Cl)cc1,,CCO,,,,val
US20120245170A1,CON(C)C(=O)c1cc([N+](=O)[O-])[nH]n1>>CON(C)C(=O)c1cc(N)[nH]n1,,C1CCOC1,CO,,,val
US20090005556A1,Cc1cc(C#N)c(Nc2ccccc2[N+](=O)[O-])s1>>Cc1cc(C#N)c(Nc2ccccc2N)s1,[Pd],CCOC(C)=O,,,,val
US20080161294A1,C1CCNC1.C[C@@H]1CN(C(=O)c2ccc(-n3cccn3)cc2Cl)c2ccccc2CN1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C[C@@H]1CN(C(=O)c2ccc(-n3cccn3)cc2Cl)c2ccccc2CN1C(=O)N1CCCC1,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US20100234365A1,CC(C)I.CN(C)C=O.O=C1O[C@@H](Cn2nnc(-c3cccnc3)n2)[C@H](c2cccc(O)c2)N1c1ccc(Cl)cc1>>Cc1ccc(-c2nnn(C[C@@H]3OC(=O)N(c4ccc(Cl)cc4)[C@H]3c3cccc(OC(C)C)c3)n2)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120129840A1,CCCC(Br)C(=O)OCC.CCOC(=O)CC(C)=O>>CCCC(C(=O)OC)C(C(C)=O)C(=O)OC,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20120142671A1,N#Cc1ccc(F)cc1Br.NC(=O)[C@H](N)CC1CCCCC1>>N#Cc1ccc(N[C@H](CC2CCCCC2)C(N)=O)cc1Br,,CCOC(C)=O,CS(C)=O,CCN(C(C)C)C(C)C,O,val
US20070049593A1,COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc(C)cc3N)[nH]c2c1.O=C(Cl)CCl>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc(C)cc3NC(=O)CCl)[nH]c2c1,,C1CCOC1,O,CC(=O)O,CC(=O)[O-].[Na+],val
US20100292242A1,CC1(C)OB(c2ccc3c(c2)CN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CC3c2ccc(Cl)c(Cl)c2)OC1(C)C.Nc1cnc(Br)cn1>>Nc1cnc(-c2ccc3c(c2)CN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CC3c2ccc(Cl)c(Cl)c2)cn1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020193367A1,CC(C)CNc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3ccnn3)c2)cc1C(F)(F)F>>CC(C)CNc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-n3ccnn3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US06531476B1,CC(C)OC(=O)NCC1CN(Cc2ccccc2)CCN1Cc1ccccc1.Cl>>CC(C)OC(=O)NCC1CNCCN1.Cl,[Pd],CC(=O)O,,,,val
US06018046,CS(=O)(=O)O.O=c1c(Cc2cccnc2)cn2c3cc(Br)ccc3c3cc(OCCCO)cc1c32>>CS(=O)(=O)O.O=c1c(Cc2cccnc2)cn2c3cc(Br)ccc3c3cc(OCCCO)cc1c32,,CO,,,,val
US20110112161A1,BrCc1cccc2c1cnn2C1CCCCO1.COc1cc(F)c(F)cc1-c1ccc(O)cc1>>COc1cc(F)c(F)cc1-c1ccc(OCc2cccc3c2cnn3C2CCCCO2)cc1,,C1CCOC1,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US06265426B1,COC(=O)c1ccc(OCC(=O)OC(C)(C)C)c(F)c1>>COC(=O)c1ccc(OCC(=O)O)c(F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020147343A1,CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@H](O)C1.CC(O)=S>>CC(=S)O[C@H]1CC[C@H](O[Si](C)(C)C(C)(C)C)C1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100249068A1,COc1ccc(C(Nc2ccn([C@@H]3O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](OC(c4ccccc4)(c4ccccc4)c4ccc(OC)cc4)[C@H]3F)c(=O)n2)(c2ccccc2)c2ccccc2)cc1>>COc1ccc(C(Nc2ccn([C@@H]3O[C@H](CO)[C@@H](OC(c4ccccc4)(c4ccccc4)c4ccc(OC)cc4)[C@H]3F)c(=O)n2)(c2ccccc2)c2ccccc2)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050143422A1,O=S(=O)(O)Cl.c1ccc(-c2ccccc2)cc1>>O=S(=O)(O)c1ccc(-c2ccccc2)cc1,,ClC(Cl)Cl,,,,val
US20060166997A1,CO.Cl.N#CC(O)c1cccc(OC(F)F)c1>>COC(=N)C(O)c1cccc(OC(F)F)c1.Cl,,C1COCCO1,ClCCl,,,val
US06159962,Cc1c(C(=O)N(C)C)sc2ncn(CCO)c(=O)c12.O=S(Cl)Cl>>Cc1c(C(=O)N(C)C)sc2ncn(CCCl)c(=O)c12,,ClCCCl,,,,val
US05723458,CC=CCC(N)(CC)C(=O)OCC>>CC=CCC(N)(CC)CO,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20060264425A1,Cn1cc2ccc(NC(=O)c3ccccc3NCc3ccnc(NC(=O)N4CCC(=O)CC4)c3)cc2n1.[Li]C>>Cn1cc2ccc(NC(=O)c3ccccc3NCc3ccnc(NC(=O)N4CCC(C)(O)CC4)c3)cc2n1,,C1CCOC1,,,,val
US20070066624A1,O=Cc1ccc(Br)nc1.O=[N+]([O-])c1ccc(O)cc1>>O=Cc1ccc(Oc2ccc([N+](=O)[O-])cc2)nc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080188452A1,CN.OC1CN(C(c2ccccc2)c2ccccc2)C1>>CNC1CN(C(c2ccccc2)c2ccccc2)C1,,CN(C)C=O,c1ccncc1,CS(=O)(=O)Cl,,val
US20070027148A1,CC(=O)c1cc(OCc2ccccc2)cc([N+](=O)[O-])c1O>>CC(=O)c1cc(OCc2ccccc2)cc(N)c1O,[Rh],CO,,ClCCl,,val
US20070232611A1,CN1C(=O)N(c2cc([N+](=O)[O-])ccc2Cl)Cc2cnc(S(C)(=O)=O)nc21>>CN1C(=O)N(c2cc(N)ccc2Cl)Cc2cnc(S(C)(=O)=O)nc21,,C1CCOC1,,[H][H],,val
US20030040538A1,CC(C)(C)C(=O)Cl.O=[N+]([O-])c1cc(O)ccc1Br>>CC(C)(C)C(=O)Oc1ccc(Br)c([N+](=O)[O-])c1,,c1ccncc1,,,,val
US20050222206A1,CN1CCC(C(=O)c2cccc(N)n2)CC1.O=C(Cl)c1ccc(F)cc1C(F)(F)F>>CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3C(F)(F)F)n2)CC1.Cl,,C1COCCO1,,,,val
US20160050930A1,CC(C)(C)OC(=O)N1[C@H]2CC[C@@H]1CC(C#N)C2.Fc1cncc(Br)c1>>CC(C)(C)OC(=O)N1[C@H]2CC[C@@H]1CC(C#N)(c1cncc(Br)c1)C2,,C1CCOC1,,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20090247746A1,COCn1c(-c2nccs2)c(Cl)c2cccc(N)c21.O=S(=O)(Cl)c1cccs1>>COCn1c(-c2nccs2)c(Cl)c2cccc(NS(=O)(=O)c3cccs3)c21,,c1ccncc1,,,,val
US20040138462A1,CC(C)(C)OC(=O)N(CCc1ccc(S(=O)(=O)c2ccc(O)cc2)cc1)C[C@H](O)c1cccc(Cl)c1.CCOC(=O)C(C)(C)Br>>CCOC(=O)C(C)(C)Oc1ccc(S(=O)(=O)c2ccc(CCN3C[C@@H](c4cccc(Cl)c4)OC3=O)cc2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20130310358A1,CCOC(=O)c1cnc(-c2cccnc2)nc1Cl.N#Cc1cccc(O)c1>>CCOC(=O)c1cnc(-c2cccnc2)nc1Oc1cccc(C#N)c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030087874A1,CC(C)(C)OC(=O)CNC(CO)c1ccccc1.O=CC(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)CN1C(c2ccccc2)COC1C(c1ccccc1)c1ccccc1,,ClCCl,,O=S(=O)([O-])[O-].[Mg+2],,val
US20070142441A1,CC(C)S(=O)(=O)Nc1cc(C(=O)O)ccc1-c1ccc(-c2sccc2NS(=O)(=O)C(C)C)cc1.CN>>CNC(=O)c1ccc(-c2ccc(-c3sccc3NS(=O)(=O)C(C)C)cc2)c(NS(=O)(=O)C(C)C)c1,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20020035266A1,CC(=O)OC(C)=O.Nc1ccc(I)cc1Cl>>CC(=O)Nc1ccc(I)cc1Cl,,C1CCOC1,,,,val
US20120077801A1,CC(N)CO.O=Cc1ccc(-c2cccc(-n3c(=O)n([C@@H]4CC[C@H](NC(=O)c5cn6cc(F)ccc6n5)CC4)c(=O)c4cc(F)cnc43)c2)cc1>>C[C@H](CO)NCc1ccc(-c2cccc(-n3c(=O)n([C@H]4CC[C@@H](NC(=O)c5cn6cc(F)ccc6n5)CC4)c(=O)c4cc(F)cnc43)c2)cc1,,ClCCCl,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US06359134B1,CC(C)N(Cc1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc4cc(NC(=O)OCC(Cl)(Cl)Cl)ccc4c3)CC2)cc1)C(C)C>>CC(C)N(Cc1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc4cc(N)ccc4c3)CC2)cc1)C(C)C,[Zn],CC(=O)O,,,,val
US20110263562A1,C[C@@H](COC1CCN(c2nc3ccc(OCC4CC4)cc3o2)CC1)NC(=O)OC(C)(C)C.Cl>>C[C@H](N)COC1CCN(c2nc3ccc(OCC4CC4)cc3o2)CC1.Cl,,CCOC(C)=O,,,,val
US20160075710A1,C=C(OCC)c1cc(=O)n(Cc2ccccc2)nc1-c1ccccc1>>CC(=O)c1cc(=O)n(Cc2ccccc2)nc1-c1ccccc1,,Cc1ccccc1,,Cl,,val
US20050227999A1,CN1CCC(CN2CCNCC2)CC1.O=C(CBr)N(c1ccccc1)c1ccccc1>>CN1CCC(CN2CCN(CC(=O)N(c3ccccc3)c3ccccc3)CC2)CC1,,CC#N,,O=C([O-])O.[Na+],,val
US20090264474A1,Cl.Nc1sc2cccnc2c1Br>>Cl.Nc1cc2ncccc2s1,[Pd],CO,,,,val
US20140121187A1,CCCC(=O)Nc1ccc(C)c(C)c1.O=C1c2ccccc2C(=O)C1(O)O>>CCCC(=O)Nc1cc(C)c(C)cc1C1(O)C(=O)c2ccccc2C1=O,,O=S(=O)(O)O,,,,val
US05260314,CC(C)CCON=O.CCOC(=O)C(C#N)C1CN2CCC1CC2>>N#CC(=NO)C1CN2CCC1CC2,,CCO,,[Na],,val
US04093654,C=C1CC(=O)O1.CC(C)(C)N.[O-]Cl>>CC(=O)C(Cl)C(=O)NC(C)(C)C,,O,,Cl,,val
US20130281434A1,Cc1cc2nc(Br)sc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C.OB(O)c1ccnc(Cl)c1>>Cc1cc2nc(-c3ccnc(Cl)c3)sc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US03995054,CCCCC.CCCCCCCCCCCCO.CCOCC.O>>CCCCCCCCCCCCOC(=O)CCC1CC1,,CCCCC,,c1ccncc1,,val
US20150197509A1,CC(C)NCC(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)ncn1.O=S(=O)(Cl)c1ccc(F)c(F)c1>>CC(C)N(CC(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)ncn1)S(=O)(=O)c1ccc(F)c(F)c1,,ClCCl,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20070032478A1,CCn1nc(C)cc1C(=O)O.Nc1ccc(Cc2ccc3c(c2)CC(=O)N3)cc1>>CCn1nc(C)cc1C(=O)Nc1ccc(Cc2ccc3c(c2)CC(=O)N3)cc1,,C1CCOC1,,O=S(Cl)Cl,,val
US20100197673A1,CCOC(=O)c1cc([N+](=O)[O-])c2[nH]c(-c3ccccc3)cc2c1>>O=[N+]([O-])c1cc(CO)cc2cc(-c3ccccc3)[nH]c12,,CO,,O,[BH4-].[Li+],val
US20090137580A1,Cc1cc2ncnc(Oc3ccc(N)c(Cl)c3)c2[nH]1.O=C=Nc1cccc(C(F)(F)F)c1>>Cc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(Cl)c3)c2[nH]1,,C1CCOC1,,,,val
US20140336106A1,COc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC2=CCCC2)C(=O)[C@@]2(C)CO2)cc1>>COc1ccc(C[C@H](N)C(=O)N[C@@H](CC2=CCCC2)C(=O)[C@@]2(C)CO2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04448784,Cl.O=C(Cc1ccccc1)NCc1cccc(N2CCc3ccccc32)c1>>Cl.c1ccc(CCNCc2cccc(N3CCc4ccccc43)c2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040122001A1,O=C(O)c1ccc2ncccc2c1>>O=C(O)c1ccc2c(c1)CCCN2,[Pd],CO,,O=C[O-].[NH4+],,val
US06774172B1,Cc1ccccc1.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1C=CC(=O)O1>>C=CCOCC=C.O=C1C=CC(=O)O1,,Cc1ccccc1,,,,val
US20050101643A1,CCC[C@H](CC)CO.CS(=O)(=O)Cl>>CCC[C@H](CC)COS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20120252815A1,CC1(C)CCc2ccc(B3OC(C)(C)C(C)(C)O3)cc21.OCCNC1CCN(c2nc(Br)cs2)CC1>>CC1(C)CCc2ccc(-c3csc(N4CCC(NCCO)CC4)n3)cc21,,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20110295022A1,CC(C)CON=O.O=C1OCCc2ccccc21>>O=C1OCc2ccccc2C1=NO,,CO,,Cl,C[O-].[Na+],val
US20110077248A1,ClCCN1CCOCC1.O=Cc1cc(O)ccc1Br>>O=Cc1cc(OCCN2CCOCC2)ccc1Br,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20080275127A1,C=CCCOc1ccc(S(=O)(=O)N(CC(=O)NOC(C)(C)OC)Cc2ccc(-n3cncn3)cc2)cc1.Cl>>C=CCCOc1ccc(S(=O)(=O)N(CC(=O)NO)Cc2ccc(-n3cncn3)cc2)cc1.Cl,,CCOC(C)=O,,,,val
US06545000B1,CC(C)(O)CN1CCNCC1.Nc1nc(Cl)cc2nc(-c3ccco3)nn12>>CC(C)(O)CN1CCN(c2cc3nc(-c4ccco4)nn3c(N)n2)CC1,,CS(C)=O,,C1CCC2=NCCCN2CC1,,val
US20080045521A1,C=C1CCN(C(=O)OC(C)(C)C)c2nc(C)ccc21>>Cc1ccc2c(n1)N(C(=O)OC(C)(C)C)CCC2C,[Pd],CO,,,,val
US20110166135A1,Cc1nc(/C=C/c2nc(C(=O)NC3CCCCC3)cc(N3CCCC3)n2)nc(N(C)C)c1C.Cl.Cl>>Cc1nc(CCc2nc(C(=O)NC3CCCCC3)cc(N3CCCC3)n2)nc(N(C)C)c1C.Cl.Cl,[Pd],CO,,,,val
US20070219210A1,COc1ccc(-n2nc(C(=O)NC(C)(C)C)cc2-c2ccc(O)cn2)cn1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc(-n2nc(C(=O)NC(C)(C)C)cc2-c2ccc(OS(=O)(=O)C(F)(F)F)cn2)cn1,,ClC(Cl)Cl,ClCCl,O,c1ccncc1,val
US20110144105A1,COC(=O)c1ccc(B(O)O)cc1.Cc1ccc(S(=O)(=O)OC(=CC2CCCC2)c2cc3cccnc3n2S(=O)(=O)c2ccccc2)cc1>>COC(=O)c1ccc(C(=CC2CCCC2)c2cc3cccnc3n2S(=O)(=O)c2ccccc2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20080139523A1,C=CCOc1ccc(C(CC(=O)OC)=NOCC)cc1>>C=CCOc1ccc(C(CC(=O)O)=NOCC)cc1,,C1CCOC1,,[Li+].[OH-],,val
US20110301143A1,CCOC(=O)Cn1nnc(-c2cnc(N3CCN(C(=O)c4ccccc4C(F)(F)F)CC3)nc2)n1>>O=C(O)Cn1nnc(-c2cnc(N3CCN(C(=O)c4ccccc4C(F)(F)F)CC3)nc2)n1,,CO,,C1CCOC1,[Li+].[OH-],val
US20140200216A1,C=Cc1ccc2cc(NC(=O)OCc3ccccc3)c(C(=O)Nc3cnccc3N3C[C@@H](NC(=O)OC(C)(C)C)[C@@H](n4ccnn4)[C@@H](C)C3)nc2c1>>CCc1ccc2cc(N)c(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)nc2c1,[Pd],C1CCOC1,CO,C1COCCO1,Cl,val
US05883102,C1CC2(CCN1)OCCO2.CCN=C=O>>CCNC1(N2CCC(=O)CC2)OCCO1,,ClCCl,,CCOCC,,val
US20100240620A1,CCOC(C)=O.Cc1nc2c(s1)CCCC2>>CC(=O)Cc1nc2c(s1)CCCC2,,C1CCOC1,,[Li]CCCC,,val
US20040242668A1,CC(C)(Cc1c[nH]c2c([N+](=O)[O-])cccc12)[N+](=O)[O-].O=S(=O)(Cl)c1ccccc1>>CC(C)(Cc1c[nH]c2c(NS(=O)(=O)c3ccccc3)cccc12)[N+](=O)[O-],[Pd],CCOC(C)=O,c1ccncc1,,,val
US20100305133A1,O=C(O)CNC(=O)c1c(O)c(Br)cc2nccnc12.OB(O)c1ccccc1>>O=C(O)CNC(=O)c1c(O)c(-c2ccccc2)cc2nccnc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20090099207A1,COc1ccc(C[C@@H]2CS(=O)(=O)C[C@H]3[C@H]2OC(=O)N3Cc2cccc(C3CC3)c2)cc1Br>>O=C1O[C@H]2[C@H](Cc3ccc(O)c(Br)c3)CS(=O)(=O)C[C@@H]2N1Cc1cccc(C2CC2)c1,,ClCCl,,BrB(Br)Br,,val
US20110160433A1,CCCCCCCCCCCCCCCCCCOCC(COCCCCCCCCCCCCCCCCCC)(COCCCCCCCCCCCCCCCCCC)COc1ccc(C=O)c(OC)c1.NO>>CCCCCCCCCCCCCCCCCCOCC(COCCCCCCCCCCCCCCCCCC)(COCCCCCCCCCCCCCCCCCC)COc1ccc(C=NO)c(OC)c1,,ClCCl,,CCN(CC)CC,Cl,val
US20100048549A1,Cc1ccc(S(=O)(=O)NC(Cc2c[nH]cn2)C(=O)NCc2ccccc2)c2ccccc12>>Cc1ccc(S(=O)(=O)N[C@H](CNCc2ccccc2)Cc2c[nH]cn2)c2ccccc12,,C1CCOC1,,CC(=O)O,,val
US20060194844A1,C1CNCCN1.COC(=O)c1ccc(F)c(F)c1>>COC(=O)c1ccc(N2CCNCC2)c(F)c1,,C1CCOC1,,,,val
US06239151B1,CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)CC(=O)n1ccnc1)[C@H](CCCc1ccccc1)C(=O)NOC1CCCCO1.Cc1ccc(S(=O)(=O)O)cc1>>CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)CC(=O)n1ccnc1)[C@H](CCCc1ccccc1)C(=O)NO.Cc1ccc(S(=O)(=O)O)cc1,,CO,,O,,val
US20120283436A1,COC1NC(=O)N(c2ccccc2)C1=O.c1ccc(-c2onc3ccccc23)cc1>>O=C(Nc1ccccc1)c1nc(-c2ccccc2)c2ccccc2n1,Cl[Ti](Cl)(Cl)Cl,C1COCCO1,,,,val
US05008263,CNc1c([N+](=O)[O-])c(COCCOC)nn1C>>CNc1[nH]nc(COCCOC)c1N,[Ni],CCO,,NN,O,val
US20100303734A1,CC1(C)OCC(CN)O1.CN(Cc1ccccc1)CC1CO1>>CN(Cc1ccccc1)CC(O)CNCC1COC(C)(C)O1,,CCO,,,,val
US06143764,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.O=C=Nc1ccc(Oc2ccccc2)cc1>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Oc5ccccc5)cc4)cc3)c2cc1OC,,Cc1ccccc1,,,,val
US20070037816A1,C#C[C@H]1CC[C@H]2CN(c3nccnc3C#N)CCN21.ON=C(Cl)c1cccc(Cl)c1>>N#Cc1nccnc1N1CCN2[C@@H](CC[C@@H]2c2cc(-c3cccc(Cl)c3)no2)C1,,ClCCl,,CCN(CC)CC,,val
US20050026836A1,CCCCOC(=O)[C@H](C)N(Cc1ccccc1)S(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1.Cl>>C[C@@H](C(=O)O)N(Cc1ccccc1)S(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1.Cl,,CCOC(C)=O,Cl,,,val
US05624936,COC(=O)Cc1cncn1Cc1ccc(C#N)cc1>>N#Cc1ccc(Cn2cncc2CC(=O)O)cc1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20060247320A1,CCOC(=O)c1nc2cc3c(nc2s1)CCC(C(C)(C)C)C3.N>>CC(C)(C)C1CCc2nc3sc(C(N)=O)nc3cc2C1,,CO,,,,val
US05942511,C=CCS.COc1nnc(Cl)c2ccccc12>>C=CCSc1nnc(OC)c2ccccc12,,CO,,[Na],,val
US20100240867A1,CCCCCCCCCCCCCCCCCCCCCCBr.O=C1c2ccccc2-c2ccc(O)cc21>>CCCCCCCCCCCCCCCCCCCCCCOc1ccc2c(c1)C(=O)c1ccccc1-2,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130231328A1,CC(C)(C)[Si](C)(C)Cl.COC(=O)[C@@H]1CC[C@@H](O)CC1>>COC(=O)[C@@H]1CC[C@@H](O[Si](C)(C)C(C)(C)C)CC1,,CN(C)C=O,,c1c[nH]cn1,,val
US20040138251A1,C1COCCN1.COc1cc(Nc2c(C#N)cnc3cc(-c4cccc(C=O)c4)sc23)c(Cl)cc1Cl>>COc1cc(Nc2c(C#N)cnc3cc(-c4cccc(CN5CCOCC5)c4)sc23)c(Cl)cc1Cl,CC(=O)O,CN(C)C=O,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05475109,CCOC(=O)C1CCN(C(=O)OC(C)(C)C)CC1.ClCc1ccc(Cl)cc1>>CCOC(=O)C1(Cc2ccc(Cl)cc2)CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120321559A1,Brc1cccc(C2CCCN2)c1.COc1ccc(C(=O)CBr)cc1>>COc1ccc(C(=O)CN2CCCC2c2cccc(Br)c2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20020028834A1,COc1ccc2c(CCC3CCN(Cc4ccccc4)CC3)noc2c1>>Oc1ccc2c(CCC3CCN(Cc4ccccc4)CC3)noc2c1,,Br,,O=C([O-])O.[Na+],,val
US20050272709A1,C1COCCN1.O=[N+]([O-])c1cccc(CBr)c1>>O=[N+]([O-])c1cccc(CN2CCOCC2)c1,,C1CCOC1,,CCN(CC)CC,,val
US20110021520A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C1COCC(CF)(c2cccc(Br)c2)N1>>FCC1(c2cccc(Br)c2)COCC(=S)N1,,C1CCOC1,,,,val
US20130150339A1,COc1cc(Cl)c(F)cc1B(O)O.O=S(=O)(Oc1c(F)c(F)c(F)c(F)c1F)c1ccc2c(Cl)nccc2c1>>COc1cc(Cl)c(F)cc1-c1nccc2cc(S(=O)(=O)Oc3c(F)c(F)c(F)c(F)c3F)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20050085541A1,Cc1cc([N+](=O)[O-])c2c(c1Oc1ccc(OCc3ccccc3)c(I)c1)CCC2>>Cc1cc(N)c2c(c1Oc1ccc(OCc3ccccc3)c(I)c1)CCC2,[Pt],CCOC(C)=O,,,,val
US20130090341A1,O=C(O)c1c(Br)ccc2c1OCO2.OC1(Cc2ccccc2)CCNCC1>>O=C(c1c(Br)ccc2c1OCO2)N1CCC(O)(Cc2ccccc2)CC1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150018377A1,C=C(C)c1cc(Oc2ccc(NC(=O)[C@@H](CC)N(C(=O)[O-])C(C)(C)C)cn2)ccc1C#N>>CC[C@@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(Oc2ccc(C#N)c(C(C)C)c2)nc1,[Pd],CO,,,,val
US06403772B1,C=CCC=C.C[Si](C)(C)Cl>>C=CCC=C[Si](C)(C)C,,CCOCC,,[Li]CCCC,,val
US20090270374A1,COC(CC(=O)Nc1cccc(F)c1)OC>>O=c1ccc2ccc(F)cc2[nH]1,,O,,O=S(=O)(O)O,,val
US20140142081A1,COC(=O)OC.Cc1cccc(C#N)n1>>COC(=O)Cc1cccc(C#N)n1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US08642582B2,CC(=O)Nc1ccc(N2CCO[C@H]([C@@H](O)C(=O)Nc3ccc(C#N)c(CN)c3)C2=O)cc1.Cl>>CC(=O)Nc1ccc(N2CCO[C@H]([C@@H](O)C(=O)Nc3ccc4c(c3)CNC4=N)C2=O)cc1.Cl,,CCO,,,,val
US04363909,COC(=O)CCCCc1csc(N=C2SC[C@@H]3Cc4ccccc4CN23)n1.Cl>>Cl.O=C(O)CCCCc1csc(N=C2SC[C@@H]3Cc4ccccc4CN23)n1,,CCO,,CCOCC,[Na+].[OH-],val
US20120196884A1,Nc1ccccc1.O=C=Nc1ccc([N+](=O)[O-])cc1Cl>>O=C(Nc1ccccc1)Nc1ccc([N+](=O)[O-])cc1Cl,,CCOC(C)=O,,,,val
US05789345,CC(C)N.O=C(O)CNCP(=O)(O)O>>CC(C)N.O=C(O)CNCP(=O)(O)O,,O,,,,val
US20130053383A1,CCC(C)c1cc(C)[nH]c(=O)c1C#N>>CCC(C)c1cc(C)[nH]c(=O)c1CN,[Ni],CO,,N,,val
US20100256363A1,C=CCC1(c2ccccc2)CCN(c2cccc(Br)c2)C(=O)O1.OB(O)c1ccc(F)cc1F>>C=CCC1(c2ccccc2)CCN(c2cccc(-c3ccc(F)cc3F)c2)C(=O)O1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20040019063A1,COC(=O)[C@@H]1[C@@H](O[Si](C)(C)C(C)(C)C)CCN1C(=O)Nc1ccc(C#N)c(Cl)c1C>>Cc1c(NC(=O)N2CC[C@H](O[Si](C)(C)C(C)(C)C)[C@H]2CO)ccc(C#N)c1Cl,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030216430A1,COc1cccc(C2(O)CCN(CC(=O)c3ccc4c(c3)CCC(=O)N4)CC2)c1>>COc1cccc(C2(O)CCN(CC(O)c3ccc4c(c3)CCC(=O)N4)CC2)c1,,CCO,,[BH4-].[Na+],,val
US20150274733A1,CC1c2cnc(NC3CCOCC3)nc2CN1C(=O)OC(C)(C)C>>CC1NCc2nc(NC3CCOCC3)ncc21,,C1COCCO1,CO,Cl,,val
US20120028937A1,CC(C)(C)OC(=O)OC(=O)[O-].O=C(O)C1CNC1>>CC(C)(C)OC(=O)N1CC(C(=O)O)C1,,C1CCOC1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US05684031,CC(C)(C)c1cc(N)cc2c1SCC2(C)C.O=S(=O)(O)C1=NCCN1>>CC(C)(C)c1cc(NC2=NCCN2)cc2c1SCC2(C)C,,CC#N,,,,val
US20060264429A1,CI.O=C1COc2ccc(CCCl)c(F)c2N1>>CN1C(=O)COc2ccc(CCCl)c(F)c21,,CN(C)C=O,ClCCl,[H-].[Na+],,val
US20100103366A1,CCCC1CCC(C2CCC(/C=C/C(=O)OCC)CC2)CC1>>CCCC1CCC(C2CCC(CCC(=O)OCC)CC2)CC1,[Pd],C1CCOC1,,[H][H],,val
US20080207897A1,O=C(N1CCc2ccc(Cl)c(OS(=O)(=O)C(F)(F)F)c2CC1)C(F)(F)F.OB(O)c1cccc(-c2ccccc2)c1>>O=C(N1CCc2ccc(Cl)c(-c3cccc(-c4ccccc4)c3)c2CC1)C(F)(F)F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,[Cs+].[F-],,val
US20090118332A1,COC(=O)c1ccc(C2CCN(C(=O)c3ccc(C)c([N+](=O)[O-])c3)CC2)cc1>>Cc1ccc(C(=O)N2CCC(c3ccc(C(=O)O)cc3)CC2)cc1[N+](=O)[O-],,CCOC(C)=O,CO,Cl,[Na+].[OH-],val
US05166367,NCC1COc2ccc(OCc3ccccc3)cc2O1.O=c1ccc2ccc(OCCCCl)cc2o1>>O=c1ccc2ccc(OCCCNCC3COc4ccc(OCc5ccccc5)cc4O3)cc2o1,,CN(C)C=O,,CCN(C(C)C)C(C)C,[I-].[Na+],val
US20160122331A1,COC(=O)c1ccc([C@H]2CC(=O)C[C@@H](C3CC3)O2)cc1.CON>>CON=C1C[C@H](c2ccc(C(=O)OC)cc2)O[C@H](C2CC2)C1,,CO,,Cl,CC(=O)[O-].[Na+],val
US20160002252A1,CC(C)(C)OC(=O)N1CCC(CBr)CC1.Nc1nc(Cl)c2c(C(F)(F)F)c[nH]c2n1>>CC(C)(C)OC(=O)N1CCC(Cn2cc(C(F)(F)F)c3c(Cl)nc(N)nc32)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05696275,CN(C)Cc1ccc(CSCCN)o1.CNC(=C[N+](=O)[O-])SC>>CN/C(=C\[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1,,O,,Cl,,val
US20150018328A1,Clc1nc(Cl)nc(Cl)n1.N#CC1(c2cc(N)ccn2)CC1>>N#CC1(c2cc(Nc3nc(Cl)nc(Cl)n3)ccn2)CC1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20050272931A1,Ic1ccnc(Nc2ccc3c(c2)OCCO3)c1.OB(O)c1cc2ccccc2s1>>c1ccc2sc(-c3ccnc(Nc4ccc5c(c4)OCCO5)c3)cc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,,,val
US04472316,BrBr.CC(C)OC(=O)CCC(=O)c1ccc(Oc2ccccc2)cc1>>CC(C)OC(=O)CC(Br)C(=O)c1ccc(Oc2ccccc2)cc1,,ClC(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04678795,CSc1ccc(CO)cn1.O=S(Cl)Cl>>CSc1ccc(CCl)cn1.Cl,,ClC(Cl)Cl,,,,val
US20150336984A1,Brc1ccc(N2C[C@@H]3CCCN[C@@H]3C2)nc1.CI>>CN1CCC[C@H]2CN(c3ccc(Br)cn3)C[C@H]21,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US05015640,Cl.N=C(OCc1ccccc1)N1Cc2ccccc2-c2ccccc2C1>>Cl.N=C(OCc1ccccc1)N1Cc2ccccc2-c2ccccc2C1,,CO,,CCCCCC,,val
US20100056509A1,Cc1ccc(S(=O)(=O)Nc2cc(Cl)cnc2C(O)c2ccnc(NCCO[Si](C)(C)C(C)(C)C)c2)cc1C(F)(F)F>>Cc1ccc(S(=O)(=O)Nc2cc(Cl)cnc2C(=O)c2ccnc(NCCO)c2)cc1C(F)(F)F,O=[Mn]=O,C1COCCO1,,,,val
US04440788,COC(=O)[C@H](CSC)NC(C)=O.NN>>CSC[C@H](NC(C)=O)C(=O)NN,,CCO,,O,,val
US20130310384A1,CC(C)O.COC(=O)c1ccc(CNS(=O)(=O)c2ccc(Cl)cc2)cc1>>COC(=O)c1ccc(CN(C(C)C)S(=O)(=O)c2ccc(Cl)cc2)cc1,,C1CCOC1,O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080116137A1,C=CC(=O)Cl.Oc1ccccc1>>C=CC(=O)Oc1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20060142265A1,CCOc1c(CO)cccc1C(C)C>>CCOc1c(C=O)cccc1C(C)C,O=[Mn]=O,c1ccccc1,,,,val
US20050148656A1,CCOC(=O)[C@H](Cc1ccc(OCC(=O)O)cc1)OCC.CCc1ccc(CNCc2ccc(F)cc2F)cc1>>CCOC(=O)[C@H](Cc1ccc(OCC(=O)N(Cc2ccc(CC)cc2)Cc2ccc(F)cc2F)cc1)OCC,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20100261771A1,CC(C)(C)OC(=O)N[C@@H](CCO)c1ccccc1C(F)(F)F.Cl>>Cl.N[C@@H](CCO)c1ccccc1C(F)(F)F,,C1COCCO1,,,,val
US20120214762A1,Nc1nccc(Cl)n1.O=C(c1n[nH]c2cc(Br)ccc12)N1CCOCC1>>Nc1nccc(-n2nc(C(=O)N3CCOCC3)c3ccc(Br)cc32)n1,,CN(C)C=O,,[H-].[Na+],,val
US20010018437A1,CN1CCSCC1=O.Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1>>CN1CCSC(Cc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)C1=O,O=[Ag],C1CCOC1,,CCCCCC,[Li]CCCC,val
US20160221959A1,COC(=O)C12CC(C(=O)OC)(C1)C2>>OCC12CC(CO)(C1)C2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080009482A1,C1CCOC1.CCBr.COC(=O)CC#N>>CCC(C#N)(CC)C(=O)OC,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20160066574A1,COc1ccc(CNC2=C(Cl)C(=O)N(c3cc(C(C)(C)C)on3)C2O)c(OC)c1>>CC(C)(C)c1cc(N2C(=O)C(Cl)=C(N)C2O)no1,,Cl,,,,val
US20140213586A1,CNS(=O)(=O)c1cccc(N)c1.O=C(c1c[nH]c2ccccc12)C(Cl)c1ccccc1>>CNS(=O)(=O)c1cccc(NC(C(=O)c2c[nH]c3ccccc23)c2ccccc2)c1,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20040014802A1,CCCC(=O)Nc1nn(COCC[Si](C)(C)C)c2cc(-c3cc(F)cc(F)c3)ccc12>>CCCC(=O)Nc1n[nH]c2cc(-c3cc(F)cc(F)c3)ccc12,,C1CCOC1,,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20110263588A1,CCN.Cn1nc(C=O)c2c1-c1ccccc1OC2>>CCNCc1nn(C)c2c1COc1ccccc1-2,,CO,ClCCl,CC(=O)O,[BH3-]C#N.[Na+],val
US20040002511A1,CCc1nn2ccccc2c1N(CCCF)C(=O)COC>>CCc1nn2ccccc2c1N(CCCF)CCOC,,C1CCOC1,,CCCCCC,CCOC(C)=O,val
US20140045862A1,Cn1nccc1[C@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CC[C@@H]1OC(=O)c1ccccc1>>Cn1nccc1[C@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CC[C@@H]1O,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US04243805,O=C(O)Cc1ccc(F)cc1Sc1ccc([N+](=O)[O-])cc1>>Nc1ccc(Sc2cc(F)ccc2CC(=O)O)cc1,[Fe],CC(=O)O,,O,[Na+].[OH-],val
US20120295900A1,C[C@]1(c2cc([N+](=O)[O-])c(OCC(=O)c3ccc(Cl)cn3)cc2F)N=C(N)OCC1(F)F>>C[C@]1(c2cc3c(cc2F)OCC(c2ccc(Cl)cn2)N3)N=C(N)OCC1(F)F,[Ni],CO,,,,val
US04302460,CCCCBr.CS(=O)C1C=Nc2ccccc2C1=O>>CCCCn1cc(S(C)=O)c(=O)c2ccccc21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150266878A1,NC[C@H](Nc1cncc(Br)c1)c1ccccc1.O=S(=O)(Cl)C1CC1>>O=S(=O)(NC[C@H](Nc1cncc(Br)c1)c1ccccc1)C1CC1,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US05708008,CS(=O)(=O)Cl.Nc1ccc2[nH]ccc2c1>>CS(=O)(=O)Nc1ccc2[nH]ccc2c1,,C1CCOC1,,CCN(CC)CC,,val
US20110112078A1,NN.O=C(O)c1ccc2c(c1)CCO2>>NNC(=O)c1ccc2c(c1)CCO2,,CCO,,CO,O,val
US20030153752A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=C(Cc1ccc(Br)cc1)Nc1ccccc1>>CC1(C)OB(c2ccc(CC(=O)Nc3ccccc3)cc2)OC1(C)C,,CN(C)C=O,,ClCCl,CC(=O)[O-].[K+],val
US20040067980A1,Nc1ccc2cn[nH]c2c1.O=Cc1ccc([N+](=O)[O-])cc1>>Nc1ccc(CNn2cnc3ccccc32)cc1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040102450A1,CCOC(=O)Cc1nc(CN2CCN(S(=O)(=O)c3cc4ccc(Cl)cc4s3)CC2=O)sc1CN>>O=C1Cc2nc(CN3CCN(S(=O)(=O)c4cc5ccc(Cl)cc5s4)CC3=O)sc2CN1,,CCO,,,,val
US06248912B1,BrC1=Cc2ccccc2C1.C[Si](C)(Cl)Cl>>C[Si](C)(Cl)C1=Cc2ccccc2C1,,C1CCOC1,,[Mg],,val
US03996255,C#C[Mg]Br.CCCCCC(O)C=CI>>C#CC(O)(C=CI)CCCCC,,C1CCOC1,,CCOCC,,val
US20090275606A1,Nc1ccc(Br)cc1F.O=C(O)c1c(Cl)cc(=O)n2c1CCC2>>O=C(O)c1c(Nc2ccc(Br)cc2F)cc(=O)n2c1CCC2,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20050267093A1,CC(C)(C)OC(=O)NC1(c2ccc(C#CC(=O)Nc3ccc(-c4ccc(Cl)cc4)cc3)cc2)CC1.O=C(O)C(F)(F)F>>NC1(c2ccc(C#CC(=O)Nc3ccc(-c4ccc(Cl)cc4)cc3)cc2)CC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US03946049,N#Cc1ccc(-c2ccc(OCc3ccccc3)cc2)o1.NO>>NC(=NO)c1ccc(-c2ccc(OCc3ccccc3)cc2)o1,,CCO,,Cl,[K+].[OH-],val
US20150299179A1,CC(C)Oc1ccc(-c2nnc(-c3cccc4c3CCC[C@H]4N)s2)cc1C#N.NS(N)(=O)=O>>CC(C)Oc1ccc(-c2nnc(-c3cccc4c3CCC[C@H]4NS(N)(=O)=O)s2)cc1C#N,,C1COCCO1,,CCN(C(C)C)C(C)C,Cl,val
US20110053897A1,COc1cncc(-c2cc3ccn(COCC[Si](C)(C)C)c(=O)c3c(Nc3ccc(C4CCN(C(=O)OC(C)(C)C)CC4)c(C)c3)n2)n1>>COc1cncc(-c2cc3cc[nH]c(=O)c3c(Nc3ccc(C4CCNCC4)c(C)c3)n2)n1,,CO,,Cl,,val
US20100292208A1,CC(C)(C)OC(=O)N1CCN(Cc2coc3cc(Oc4nc5ncccc5s4)ccc23)CC1.Cl>>Cl.c1cnc2nc(Oc3ccc4c(CN5CCNCC5)coc4c3)sc2c1,,ClCCl,,,,val
US20100204274A1,CC(C)(C)OC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)[C@@](C)(O)C1.Cl>>C[C@]1(O)CNCC[C@]1(O)c1ccc(Cl)cc1.Cl,,Cl,,C1COCCO1,,val
US20120142727A1,C1CCNC1.COC(=O)c1ccc2ncc(Cl)c(Cl)c2c1>>COC(=O)c1ccc2ncc(Cl)c(N3CCCC3)c2c1,,O,,CN1CCCC1=O,,val
US20140005382A1,ICCC1CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>[I-].c1ccc([P+](CCC2CC2)(c2ccccc2)c2ccccc2)cc1,,CC#N,,CCOCC,,val
US04959366,CN(CCOc1ccc(C(N)=O)cc1)CCc1ccc(N)cc1.CS(=O)(=O)OS(C)(=O)=O>>CN(CCOc1ccc(C(N)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,,ClCCl,,,,val
US04005082,ClC1=NOCc2ccc(Cl)cc21.NN>>NNC1=NOCc2ccc(Cl)cc21,,CCO,,,,val
US20160139133A1,COC(=O)c1cc(C(=O)OC)cc(C(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)c1cc(C(=O)O)cc(C(=O)O)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20160145251A1,[N-]=[N+]=NC1CC(C(=O)Nc2ccc(Cl)cc2)CN(C(=O)c2cccc(-c3ccco3)c2)C1>>NC1CC(C(=O)Nc2ccc(Cl)cc2)CN(C(=O)c2cccc(-c3ccco3)c2)C1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160052889A1,COC(=O)c1ccc([C@H](C)NC(=O)[C@H]2Cc3ccccc3CN2)cc1.O=CCOc1ccc(F)cc1>>COC(=O)c1ccc([C@H](C)NC(=O)[C@H]2Cc3ccccc3CN2CCOc2ccc(F)cc2)cc1,,ClCCCl,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130116249A1,COC(=O)c1cccc(B(O)O)c1.Cc1nc2ccc(C(=O)c3c(C)c(Br)c4ccccn34)cc2c(=O)[nH]1>>COC(=O)c1cccc(-c2c(C)c(C(=O)c3ccc4nc(C)[nH]c(=O)c4c3)n3ccccc23)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US04053606,C=Cc1cnc(C)c(OCc2ccccc2)c1CO.O=S(Cl)Cl>>C=Cc1cnc(C)c(OCc2ccccc2)c1CCl,,c1ccccc1,,,,val
US04472578,CCOC(=O)C1=C(OC)C(=O)c2ccccc2C1=O.Nc1ccccc1N>>CCOC(=O)c1c(O)c2ccccc2c2nc3ccccc3nc12,,CCO,,,,val
US20050245741A1,CC(=O)OC(C)=O.COc1ccc([N+](=O)[O-])c(OC[C@H]2CO2)c1>>COc1ccc(NC(C)=O)c(OC[C@H]2CO2)c1,[Pd],CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US20090220420A1,CCN(CC)C(=O)C1Sc2ccccc2-c2c1c1ccccc1n2CCO.CI>>CCN(CC)C(=O)C1Sc2ccccc2-c2c1c1ccccc1n2CCOC,,CS(C)=O,,[K+].[OH-],,val
US20160159752A1,C=C[C@H]1CCC[C@@H]1N.O=C(Cl)OCc1ccccc1>>C=C[C@H]1CCC[C@@H]1NC(=O)OCc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130053366A1,Cc1ccc2c(c1)c1c(n2C#Cc2cncc(F)c2)CCN(C)C1>>Cc1ccc2c(c1)c1c(n2CCc2cncc(F)c2)CCN(C)C1,[Pd],CO,,O=C[O-].[NH4+],,val
US05424444,CC(=O)C=CC1CCCN1C(=O)OCc1ccccc1.NO>>CC(C=CC1CCCN1C(=O)OCc1ccccc1)=NO,,CO,,Cl,CC(=O)[O-].[Na+],val
US04996218,BrCCCCCBr.OCCc1ccc2ccccc2n1>>BrCCCCCOCCc1ccc2ccccc2n1,,ClCCl,O,[Na+].[OH-],,val
US20130296329A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(O)C1Cc2cc(Cl)ccc2N1>>CC(C)(C)OC(=O)N1c2ccc(Cl)cc2CC1C(=O)O,,C1COCCO1,,Cl,[Na+].[OH-],val
US05639732,CCOP(=O)(CCCN1CCOCC1)c1ccccc1>>O=P(O)(CCCN1CCOCC1)c1ccccc1,,Cl,,,,val
US20100063120A1,C#CCC(N=Cc1ccc(Cl)cc1)(C(=O)OC)c1ccc(OC)cc1>>C#CCC(N)(C(=O)OC)c1ccc(OC)cc1,,CCOCC,O,Cl,,val
US05516774,O=Cc1nccn1Cc1ccccc1[N+](=O)[O-]>>c1ccc2c(c1)Cn1ccnc1CN2,,CCO,,,,val
US20040142933A1,CN1C(=O)Cc2cc(C(=O)CCl)ccc21>>CN1C(=O)Cc2cc(CCCl)ccc21,,O,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20130178625A1,COc1cccc(-n2c(=O)c(=O)[nH]c3c4ccccc4ccc32)c1>>O=c1[nH]c2c3ccccc3ccc2n(-c2cccc(O)c2)c1=O,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US04904775,CC1(C)Oc2cc3nc(C(=O)O)c(C(=O)O)nc3cc2O1>>O=C(O)c1nc2cc(O)c(O)cc2nc1C(=O)O,,Cl,,,,val
US20070232649A1,COc1ccc(CS(=O)(=O)CC(=O)O)cc1.O=Cc1cc(Cl)ccc1O>>COc1ccc(CS(=O)(=O)c2cc3cc(Cl)ccc3oc2=O)cc1,,CC(=O)O,,,,val
US06416939B1,Cc1ccc(S(=O)(=O)OCCCl)cc1.O=[N+]([O-])c1cccc2[nH]ccc12>>O=[N+]([O-])c1cccc2c1ccn2CCCl,,C1CCOC1,,[H-].[Na+],,val
US04617307,CCOC(=O)C1(c2ccc(C#N)cc2)CCCc2cncn21>>N#Cc1ccc(C2CCCc3cncn32)cc1,,CO,,Cl,[Na+].[OH-],val
US20130005771A1,COc1ccc(C=Cc2nc(CC3CCN(C(=O)OC(C)(C)C)CC3)no2)cc1OC>>COc1ccc(C=Cc2nc(CC3CCNCC3)no2)cc1OC,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080188528A1,Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](N)C(=O)OC(C)(C)C)c(C)c2c1OC(C)(C)CC2.O=C(O)c1cccn(-c2ccc3ccccc3c2)c1=O>>Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)c2cccn(-c3ccc4ccccc4c3)c2=O)C(=O)OC(C)(C)C)c(C)c2c1OC(C)(C)CC2,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05712303,CCOc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(N2C(=O)c3ccccc3C2=O)c1C(=O)c1ccccc1Cl>>CCOc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(N)c1C(=O)c1ccccc1Cl,,CCO,,NN,O,val
US20100048568A1,CC(=O)NN1CC(C(C)(C)C)=NNC1=O>>CC(C)(C)C1=NNC(=O)N(N)C1,,CO,,Cl,[Na+].[OH-],val
US04971980,CCOCCCl.CN(C)CCCc1nc2ccccc2[nH]1>>CCOCCn1c(CCCN(C)C)nc2ccccc21,,CN(C)C=O,,O,[H-].[Na+],val
US20160150782A1,CCCC(C)N.Cc1cc(C(=O)O)c(=O)[nH]c1C>>CCCC(C)NC(=O)c1cc(C)c(C)[nH]c1=O,,C1CCOC1,,Cl,,val
US20020016337A1,Clc1ccc(C2(CN3CCCC(CNc4ccccc4)C3)CCC2)cc1.O=C(Cl)C1CCC1>>O=C(C1CCC1)N(CC1CCCN(CC2(c3ccc(Cl)cc3)CCC2)C1)c1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130059834A1,C[C@@H](NC(=O)OC(C)(C)C)C(=O)NCCO.O=C(O)C(F)(F)F>>C[C@@H](N)C(=O)NCCO.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05145970,C=CC(=O)OC.Cc1cc(S)cc(C(C)(C)C)c1N>>COC(=O)CCSc1cc(C)c(N)c(C(C)(C)C)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20090275537A1,C=CC[C@@H](CO[Si](C)(C)C(C)(C)C)N(C)C(=O)OC(C)(C)C.Cl>>C=CC[C@@H](CO)NC.Cl,,CO,,,,val
US20110144100A1,CC(C)(C)OC(=O)NCC1CCN(c2cccc3ccc(-c4nnc5cc(C=O)ccn45)nc23)CC1.CCN>>CCNCc1ccn2c(-c3ccc4cccc(N5CCC(CNC(=O)OC(C)(C)C)CC5)c4n3)nnc2c1,,CO,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100190747A1,O=[N+]([O-])c1ccc(F)c(F)c1.OCC(F)(F)F>>O=[N+]([O-])c1ccc(OCC(F)(F)F)c(F)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100249179A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1CO.COC(=O)c1csc2cc(-c3ccc(O)cc3)ccc12>>COC(=O)c1csc2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)cc3)ccc12,,ClCCl,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06987119B2,CCN(CC)CC.CN(C)CCN.O=C(Cl)c1nc(-c2ccncc2)c(-c2ccc(Cl)c(O)c2)[nH]1>>CN(C)CCNC(=O)c1nc(-c2ccncc2)c(-c2ccc(Cl)c(O)c2)[nH]1.N,,ClCCl,,,,val
US20070066632A1,N=C(N)c1cc(Cl)ccc1F.O=C(Cl)c1ccc(F)nc1F>>Oc1nc(-c2cc(Cl)ccc2F)nc2nc(F)ccc12,,CC#N,,CCN(C(C)C)C(C)C,,val
US20120022056A1,C=CCc1cccc2nc(C(C(=O)OCC)[N+](=O)[O-])ccc12.CC(=O)O>>C=CCc1cccc2c1ccc1c(C(=O)OCC)ncn12,[Zn],,,,,val
US20040082642A1,Cl[Mg]Cc1ccccc1.O=C1c2cc(O)ccc2CC12Cc1ccc(O)cc1C2>>Oc1ccc2c(c1)CC1(C2)Cc2ccc(O)cc2C1=Cc1ccccc1,,C1CCOC1,,Cl,,val
US20050261291A1,CC1(C)CC(c2ccccc2C2=CCN(C(=O)OC(C)(C)C)CC2)CC(C)(C)C1>>CC1(C)CC(c2ccccc2C2=CCNCC2)CC(C)(C)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110021556A1,CCOC(=O)c1cc2cc(C3(Cc4ccccc4)CCN(Cc4ccccc4)C3)ccc2n1C(=O)OC(C)(C)C.CN>>CNC(=O)c1cc2cc(C3(Cc4ccccc4)CCN(Cc4ccccc4)C3)ccc2[nH]1,,Cc1ccccc1,,C[Al](C)C,Cl,val
US20090221608A1,Cc1c(C)n(S(=O)(=O)c2ccccc2)c2ncc(Br)cc12>>Cc1[nH]c2ncc(Br)cc2c1C,,C1CCOC1,CO,CCOC(C)=O,[Na+].[OH-],val
US20020111492A1,CCOC(=O)C1(CCCc2c(F)cnc3ccc(OC)cc23)CCN(CCOc2c(F)cccc2F)CC1>>COc1ccc2ncc(F)c(CCCC3(C(=O)O)CCN(CCOc4c(F)cccc4F)CC3)c2c1,,C1COCCO1,CO,[Na+].[OH-],,val
US06200981B1,CC(C)(C)O.Cc1cccc(C(=O)Cl)c1>>Cc1cccc(C(=O)OC(C)(C)C)c1,,C1CCOC1,,[Li]CCCC,,val
US04242519,CSC(C)(C(=O)O)c1ccc(NC(=O)c2ccccc2C(=O)O)cc1>>CSC(C)(C(=O)O)c1ccc(N2C(=O)c3ccccc3C2=O)cc1,,CC(=O)O,,,,val
US20050136444A1,Cl.N=C(N)NN.O=Cc1ccc(-c2ccccc2F)cc1>>Cl.N=C(N)NN=Cc1ccc(-c2ccccc2F)cc1,,CCO,,O,[Na+].[OH-],val
US20020115861A1,CC(C)Cn1c(CC(C)O)nc2cnc3ccccc3c21.CI>>COC(C)Cc1nc2cnc3ccccc3c2n1CC(C)C,,CN(C)C=O,,[H-].[Na+],,val
US05041629,O=C(c1cc([N+](=O)[O-])ccc1Cl)N(CCO)CCO>>O=C1c2cc([N+](=O)[O-])ccc2OCCN1CCO,,O,,[K+].[OH-],,val
US20040058964A1,N.O=c1c(Br)c(OCc2ccc(F)cc2F)ccn1Cc1cccc(CBr)c1F>>NCc1cccc(Cn2ccc(OCc3ccc(F)cc3F)c(Br)c2=O)c1F,,CO,,,,val
US20140315886A1,Cc1cc(C2(F)COC2)ccc1-c1ccc2nc(-c3cccnc3)nc(N(C)C(=O)OC(C)(C)C)c2c1>>CNc1nc(-c2cccnc2)nc2ccc(-c3ccc(C4(F)COC4)cc3C)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US04649197,CC(O)C(O)c1cnc2[nH]c(N)nc(=O)c2n1.Cl>>CC(O)C(O)C1CNc2[nH]c(N)nc(=O)c2N1.Cl,O=[Pt],,,[H][H],,val
US05409936,CCCc1nc2c(n1Cc1ccc(-c3ccccc3C(=O)OC(C)(C)C)cc1)C(C(=O)OCC)N(C(=O)CC(=O)OCC)CC2>>CCCc1nc2c(n1Cc1ccc(-c3ccccc3C(=O)O)cc1)C(C(=O)OCC)N(C(=O)CC(=O)OCC)CC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080015246A1,CCOC(=O)c1ccc(-c2ccc(CCCBr)c(-c3ccc(N(CC)CC)c(C(C)(C)C)c3)c2)cc1.O=C1NC(=O)c2ccccc21>>CCOC(=O)c1ccc(-c2ccc(CCCN3C(=O)c4ccccc4C3=O)c(-c3ccc(N(CC)CC)c(C(C)(C)C)c3)c2)cc1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20070219230A1,C=Cc1ccc(-c2ncccc2[N+](=O)[O-])cc1.CC=C(C)[Mg]Br>>C=Cc1ccc(-c2nccc3c(C)c(C)[nH]c23)cc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20080255112A1,Clc1cc(Cl)ncn1.Clc1nc2ccccc2[nH]1>>Clc1cc(-n2c(Cl)nc3ccccc32)ncn1,,CN(C)C=O,,O,[H-].[Na+],val
US04177290,CCOC(=O)CC(=O)N(c1ccccc1)c1ccccc1>>O=C(O)CC(=O)N(c1ccccc1)c1ccccc1,,CCO,O,Cl,[K+].[OH-],val
US05516788,CI.c1ccc2c(c1)C[C@@H]1c3ccccc3N[C@H]21>>CN1c2ccccc2[C@H]2Cc3ccccc3[C@H]21,,C1CCOC1,,O,[H-].[Na+],val
US20050288346A1,Cc1c(O)cccc1O.O=C(Cl)CC1CCCC1>>Cc1c(O)ccc(C(=O)CC2CCCC2)c1O,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130059846A1,Br[Mg]C1CC1.Cc1ccc(-c2noc(C3CC(=O)C3)n2)cc1NC(=O)c1cnc2ccccn12>>Cc1ccc(-c2noc(C3CC(O)(C4CC4)C3)n2)cc1NC(=O)c1cnc2ccccn12,,C1CCOC1,,,,val
US20090054437A1,CNC(=O)c1cc(OC)c(OC)c([N+](=O)[O-])c1.ClP(Cl)(Cl)(Cl)Cl>>CN=C(Cl)c1cc(OC)c(OC)c([N+](=O)[O-])c1,,Cc1ccccc1,,,,val
US20110257151A1,CC1(C)Cc2cc(C(=O)O)ccc2NC1c1cccc(N2CCOC2=O)c1.NS(=O)(=O)C1CC1>>CC1(C)Cc2cc(C(=O)NS(=O)(=O)C3CC3)ccc2NC1c1cccc(N2CCOC2=O)c1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20040014962A1,CS(=O)(=O)Cl.O=C(NCc1csc(N2CC(O)C2)n1)c1ccccc1>>CS(=O)(=O)OC1CN(c2nc(CNC(=O)c3ccccc3)cs2)C1,,ClCCl,,CCN(CC)CC,c1ccncc1,val
US20110224155A1,COCCCNc1cccc([N+](=O)[O-])c1C#N>>COCCCNc1cccc(N)c1C#N,[Pd],CCO,,C1=CCCCC1,,val
US20100292206A1,CCOC(=O)CC(=O)N1CCC(COc2ccccc2C(C)(C)C)C1>>CC(C)(C)c1ccccc1OCC1CCN(C(=O)CC(=O)O)C1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20150284409A1,CC[C@@H]1[C@@H](C=O)N1C(=O)OC(C)(C)C.CO>>CC[C@@H]1[C@@H](C(=O)OC)N1C(=O)OC(C)(C)C,O=[Mn]=O,,,[C-]#N.[Na+],,val
US20140100231A1,COc1nnc(C(F)F)cc1COC(C)(C)C>>COc1nnc(C(F)F)cc1CO,,C1CCOC1,ClCCCl,,,val
US06060508,CC(=O)CCl.Sc1ccccc1Br>>CC(=O)CSc1ccccc1Br,,CN(C)C=O,O,[I-].[K+],,val
US20070254892A1,C=CCn1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(N)n1.CC(=O)OC(C)=O>>C=CCn1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(NC(C)=O)n1,,c1ccncc1,,,,val
US20160272621A1,C1COCCN1.O=[N+]([O-])c1cnc(F)cc1F>>O=[N+]([O-])c1cnc(F)cc1N1CCOCC1,,C1CCOC1,,CCN(CC)CC,,val
US20160229857A1,C=O.CC(C)(C)C(=O)Nc1nc(O)c2ccnc-2[nH]1.CN>>CNCc1cc2cnc[nH]c-2n1,,CC(=O)O,,CO,ClC(Cl)Cl,val
US20060276523A1,CCCCc1nc(Cl)c(C(=O)O)[nH]1.OCCCBr>>CCCCc1nc(Cl)c(C(=O)OCCCBr)[nH]1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100048551A1,NC(=O)c1c[nH]c(=O)c2c1sc1cc(Br)ccc12.O=P(Cl)(Cl)Cl>>N#Cc1cnc(Cl)c2c1sc1cc(Br)ccc12,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20040122000A1,CC(C)CN(C[C@H]1OC(C)(C)N(C(=O)O[C@@H]2CO[C@H]3OCC[C@H]32)[C@H]1Cc1ccc(OCc2cccc(C#N)c2)cc1)S(=O)(=O)c1ccc(N)cc1>>CC(C)CN(C[C@@H](O)[C@H](Cc1ccc(OCc2cccc(C#N)c2)cc1)NC(=O)O[C@@H]1CO[C@H]2OCC[C@H]21)S(=O)(=O)c1ccc(N)cc1,,C1COCCO1,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20060106082A1,Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(=O)(=O)NS(=O)(=O)c3ccccc3)cc2)cc1.O=C(Cl)CCCCl>>Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(=O)(=O)NC(=O)CCCCl)cc2)cc1,,c1ccncc1,,Cl,,val
US20150065482A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCC(O)C(=O)O>>CC(C)(C)OC(=O)NCCC(O)C(=O)O,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20070066639A1,CC(=O)OC(C)=O.O=[N+]([O-])c1cnc2ccccc2c1NCCOCCO>>CC(=O)OCCOCCNc1c([N+](=O)[O-])cnc2ccccc12,,c1ccncc1,,,,val
US20030013704A1,CC(C)(C)OC(=O)NC1(C=O)CC1.O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(CNCCO)ccc1Cl>>CC(C)(C)OC(=O)NC1(CN(CCO)Cc2ccc(Cl)c(C(=O)NCC34CC5CC(CC(C5)C3)C4)c2)CC1,,ClCCl,,O=C([O-])O.[Na+],,val
US20080033016A1,CCCN=C=S.COc1ccc(Cl)cc1C(=O)NCCC1CCN(S(N)(=O)=O)CC1>>CCCNC(=S)NS(=O)(=O)N1CCC(CCNC(=O)c2cc(Cl)ccc2OC)CC1,,CN1CCCC1=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150071918A1,CC(C)(C)OC(=O)CN(CCNC(=O)OCC1c2ccccc2-c2ccccc21)S(=O)(=O)CCCN=[N+]=[N-]>>[N-]=[N+]=NCCCS(=O)(=O)N(CCNC(=O)OCC1c2ccccc2-c2ccccc21)CC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110288280A1,CC(=O)OC(C)=O.O=C(Cc1ccc(O)cc1)Nc1ncc(-c2ccc(O)cc2)nc1Cc1ccccc1>>CC(=O)Oc1ccc(CC(=O)Nc2ncc(-c3ccc(OC(C)=O)cc3)nc2Cc2ccccc2)cc1,,c1ccncc1,,CCOC(C)=O,O=C([O-])O.[Na+],val
US04731483,CC(Br)c1cccc(C(=O)c2ccccc2)c1.O>>CC(O)c1cccc(C(=O)c2ccccc2)c1,,O,,O=C([O-])[O-].[Ca+2],,val
US20040132727A1,COc1cc2nccc(Oc3ccc(N)cc3C)c2cc1OC.O=C(N=C=S)c1ccccc1>>COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)c4ccccc4)cc3C)c2cc1OC,,CCO,,Cc1ccccc1,,val
US20030229081A1,O=c1cc(Cl)[nH]c(=O)[nH]1.Oc1ccc(S)cc1>>O=c1cc(Sc2ccc(O)cc2)[nH]c(=O)[nH]1,,CCO,,[K+].[OH-],,val
US20110244481A1,CC(C)(C)[Si](C)(C)Oc1ccc(-c2cnc(N)c(Br)n2)cc1.OB(O)c1csc2ccccc12>>CC(C)(C)[Si](C)(C)Oc1ccc(-c2cnc(N)c(-c3csc4ccccc34)n2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],val
US20120095020A1,CC(C)(C)OC(=O)N1CCN(c2ccc3c(c2)[C@H](NC(=O)c2ccc(F)cc2)[C@@H](O)C3)C(=O)C1>>CC(C)(C)OC(=O)N1CCN(c2ccc3c(c2)[C@H](NC(=O)c2ccc(F)cc2)[C@@H](O)C3)CC1,,C1CCOC1,CCOC(C)=O,O,O=C([O-])O.[Na+],val
US20080293706A1,Cn1cc(-c2cnc3ccc(-c4cncc(N)c4)cc3n2)cn1.N#Cc1ccc(S(=O)(=O)Cl)cc1>>Cn1cc(-c2cnc3ccc(-c4cncc(NS(=O)(=O)c5ccc(C#N)cc5)c4)cc3n2)cn1,,c1ccncc1,,,,val
US20070173526A1,CC(C)OC(=O)Cl.CCOC(=O)c1cnc2ccsc2c1O>>CCOC(=O)c1cn(C(=O)OC(C)C)c2ccsc2c1=O,,ClCCl,,c1ccncc1,,val
US20090198063A1,Cc1ccc2c(n1)NC(=O)CC2.O=[Se]=O>>O=Cc1ccc2ccc(=O)[nH]c2n1,,C1COCCO1,,,,val
US20150119393A1,CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@H](Oc3nc4cc(Cl)c(-c5ccc([C@@H]6CC[C@@H](N)CC6)cc5)nc4n3COCC[Si](C)(C)C)CO[C@H]12.O=C(Cl)OC(Cl)(Cl)Cl.OC1CCOCC1>>CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@H](Oc3nc4cc(Cl)c(-c5ccc([C@@H]6CC[C@@H](NC(=O)OC7CCOCC7)CC6)cc5)nc4n3COCC[Si](C)(C)C)CO[C@H]12,,Cc1ccccc1,,,,val
US20080167348A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1c[nH]c2ccc(F)cc12>>Cc1cn(C(=O)OC(C)(C)C)c2ccc(F)cc12,CN(C)c1ccncc1,C1CCOC1,,,,val
US20140113882A1,CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)C(C=O)C1.COP(=O)(OC)C(=[N+]=[N-])C(C)=O>>C#CC1CN(C(=O)OC(C)(C)C)CCN1C(=O)OC(C)(C)C,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20070191336A1,CC(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2cccc(CO)c2)n1>>CC(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2cccc(C=O)c2)n1,O=[Mn]=O,ClCCl,,,,val
US04523030,COC(=O)C1=Cc2ccc(OC)cc21>>COC(=O)C1=Cc2ccc(O)cc21,,ClCCl,,BrB(Br)Br,,val
US20050054658A1,CCOC(=O)Cl.O=C(O)[C@@H]1C[C@H]1c1ccccc1>>CCOC(=O)[C@@H]1C[C@H]1c1ccccc1,CN(C)c1ccncc1,CCN(CC)CC,,,,val
US06194450B1,Br.COC(=O)c1ccc(O)c(CO)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1ccc(O)c(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1.[Br-],,CC#N,,,,val
US20160002214A1,COc1ccc2[nH]c(-c3ccc(/C(N)=N/O)cc3)nc2c1.O=C(O)c1ccc(F)cc1>>COc1ccc2[nH]c(-c3ccc(-c4noc(-c5ccc(F)cc5)n4)cc3)nc2c1,,CN(C)C=O,,O=C(c1ncc[nH]1)c1ncc[nH]1,,val
US20120208798A1,CC(=O)N1c2ccc(-c3cn(CCCNC(=O)OC(C)(C)C)nn3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.Cl>>CC(=O)N1c2ccc(-c3cn(CCCN)nn3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.Cl,,C1COCCO1,,,,val
US04426524,CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)Cl.OCc1cccc(-c2ccco2)c1>>CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)OCc1cccc(-c2ccco2)c1,,Cc1ccccc1,,c1ccncc1,,val
US20050020618A1,CC(C)(Cc1cnc2c(Br)cccn12)[N+](=O)[O-].OB(O)c1cccs1>>CC(C)(Cc1cnc2c(-c3cccs3)cccn12)[N+](=O)[O-],c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US04052511,O=C(O)[C@@H]1CCCN1.O=C1CCC(=O)O1>>O=C(O)CCC(=O)N1CCC[C@H]1C(=O)O,,CC(=O)O,,,,val
US07479575B2,CCc1ccc(/C(Cl)=C/c2ccc(Br)cc2)cc1>>CCc1ccc(C#Cc2ccc(Br)cc2)cc1,,C1COCCO1,CO,[K+].[OH-],,val
US20090076062A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H]2C[C@@H](C(C)C)C(=O)O2)C(C)C)ccc1C>>COCCCOc1cc(C[C@@H](C[C@H](NC(=O)OC(C)(C)C)[C@@H]2C[C@@H](C(C)C)C(=O)O2)C(C)C)ccc1C,,ClCCl,,CCN(CC)CC,,val
US20040082806A1,CCOC(=O)C1C2C(=O)CC(O[Si](C)(C)C(C)(C)C)C21>>CCOC(=O)C1C2C=CC(=O)C21,,ClC(Cl)Cl,,,,val
US20060241115A1,COc1ccc(Oc2ccc3c(C(=O)[O-])cccc3c2)cn1>>COc1ccc(Oc2ccc3c(C(=O)O)cccc3c2)cn1,,C1CCOC1,,[Li+].[OH-],,val
US07323465B2,CCS(=O)(=O)Nc1ncnc(OCCO)c1-c1ccc(C)cc1.Clc1ncc(Br)cn1>>CCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(C)cc1,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20120184553A1,O=C(OCc1ccccc1)c1ccc(OCc2ccccc2)c(C(=O)OCc2ccccc2)c1>>O=C(O)c1ccc(OCc2ccccc2)c(C(=O)O)c1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20070185088A1,CC(C)(C)OC(=O)N1CCc2ccc(O)cc2CC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2CC1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20130296355A1,CC(C)(C)OC(=O)CCNC(=O)c1cccnc1N(Cc1ccc(-n2cc(C(F)(F)F)cn2)nc1)C1CCCCC1>>O=C(O)C=CNC(=O)c1cccnc1N(Cc1ccc(-n2cc(C(F)(F)F)cn2)cc1)C1CCCCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100317659A1,Cc1ccc(C(N)=O)c(N)c1.O=C1OC(=O)C(c2ccc(F)cc2)O1>>Cc1ccc2c(O)nc(C(O)c3ccc(F)cc3)nc2c1,,C1CCOC1,,CO,C[O-].[Na+],val
US20160002218A1,C=O.CC(=O)O.CCCOc1ccc(-c2csc(NC(=O)c3cnc(N4CCC(C(=O)OCC)CC4)cn3)n2)cc1C(F)(F)F>>CCCOc1ccc(-c2nc(NC(=O)c3cnc(N4CCC(C(=O)OCC)CC4)cn3)sc2COC(C)=O)cc1C(F)(F)F,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20090197866A1,CN1CCCN(c2cc3[nH]c(-c4nn(C5CCCCO5)cc4[N+](=O)[O-])nc3cc2F)CC1>>CN1CCCN(c2cc3[nH]c(-c4nn(C5CCCCO5)cc4N)nc3cc2F)CC1,[Pd],CO,,[H][H],,val
US20080090801A1,COc1ccc(B(O)O)cn1.CSc1nc(C)c2cc(Br)c(=O)[nH]c2n1>>COc1ccc(-c2cc3c(C)nc(SC)nc3[nH]c2=O)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US07250518B2,COC(=O)C(C)(C)c1ccc(CNC(=O)c2cccnc2Oc2ccc3c(c2)OCO3)cc1>>CC(C)(C(=O)O)c1ccc(CNC(=O)c2cccnc2Oc2ccc3c(c2)OCO3)cc1,,CC(C)(C)O,,[Na+].[OH-],,val
US20100075948A1,CO.N#CCc1ccc(Cl)cc1F.O=Cc1cc(Cl)ccc1F>>COc1ccc(Cl)cc1/C=C(\C#N)c1ccc(Cl)cc1F,,CO,,C[O-].[Na+],,val
US20100093788A1,CS(=O)(=O)O.FC(F)(F)Oc1ccccc1-c1cc(Cl)c2[nH]c(C3=NOC4(CCCCC4)C3)nc2c1>>CS(=O)(=O)O.FC(F)(F)Oc1ccccc1-c1cc(Cl)c2[nH]c(C3=NOC4(CCCCC4)C3)nc2c1,,CCOC(C)=O,,,,val
US20050026964A1,CCOC(=O)c1cn(CC)c(=O)cc1Nc1ccc(I)cc1F>>CCn1cc(C(=O)O)c(Nc2ccc(I)cc2F)cc1=O,,CCO,,[Na+].[OH-],,val
US20140031364A1,COC(=O)CC#N.ON=C(Cl)c1ccccc1OC(F)(F)F>>COC(=O)c1c(-c2ccccc2OC(F)(F)F)noc1N,,CO,,C[O-].[Na+],,val
US20130059834A1,COC(=O)c1cn(COC(=O)C(C)(C)C)c2ncc(-c3nn(C)c4ccc(S(C)(=O)=O)cc34)nc12>>Cn1nc(-c2cnc3[nH]cc(C(=O)O)c3n2)c2cc(S(C)(=O)=O)ccc21,,C1COCCO1,O,[Na+].[OH-],,val
US04670441,CCOC(=O)C1C(=O)N(C)C(=S)N(C)C1=O.Nc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1>>CN1C(=O)C(C(=O)Nc2ccc(Oc3ccc(C(F)(F)F)cn3)cc2)C(=O)N(C)C1=S,,CN(C)C=O,,,,val
US04567162,CC(=O)O.CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1>>CC(C)O.CCOC(C)=O.O=C(OCc1ccccc1)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1,,CC(=O)O,Cl,,,val
US05663200,COCC(C)O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COCC(C)OC(=O)Cl,,CCOCC,,c1ccncc1,,val
US20080261957A1,CC(C)CNc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(Br)c2)cc1C(F)(F)F>>CC(C)CNc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(Br)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100137322A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1cccc2c1C[C@H](N(Cc1ccccc1)Cc1ccccc1)CO2>>O=S(=O)(Oc1cccc2c1C[C@H](N(Cc1ccccc1)Cc1ccccc1)CO2)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20160024009A1,N#Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(N2CCOCC2)c1>>NCc1cc(-c2ccc(C(F)(F)F)cc2)nc(N2CCOCC2)c1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04719223,COC(CNC(=S)Nc1cc(F)c(N)c(F)c1)OC>>Nc1c(F)cc(-n2ccnc2S)cc1F,,O,O=S(=O)(O)O,,,val
US06239074B1,CC(Cl)OC(=O)C=Cc1cc(N)ccc1Cl.O=C(Cl)OC(Cl)(Cl)Cl>>CC(Cl)OC(=O)C=Cc1cc(N=C=O)ccc1Cl,,Cc1ccccc1,,,,val
US20140221343A1,Nc1nccc2c1nc(Sc1cc3c(cc1Cl)OCO3)n2CCN1C(=O)c2ccccc2C1=O>>NCCn1c(Sc2cc3c(cc2Cl)OCO3)nc2c(N)nccc21,,CCO,ClCCl,,,val
US04061656,Clc1cc(CBr)c(Cl)s1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Clc1cc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c(Cl)s1.[Br-],,c1ccccc1,,,,val
US20090005558A1,CS(=O)(=O)Cl.OCCc1noc2ccccc12>>CS(=O)(=O)OCCc1noc2ccccc12,,ClCCl,,CCN(CC)CC,,val
US04161538,CC(C(=O)O)c1ccc(CC2CCCC2=NO)cc1.N=C(N)NCCC[C@H](N)C(=O)O>>CC(C(=O)O)c1ccc(CC2CCCC2=NO)cc1.N=C(N)NCCC[C@H](N)C(=O)O,,CC(C)=O,O,,,val
US06410684B1,COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.Cl>>COC(=O)C[C@H](N)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.Cl,,CCOC(C)=O,,,,val
US20100093788A1,Cc1cc(-c2ccccc2F)cc(N)c1N.O=CC1=NOC2(CCCCC2)C1>>Cc1cc(-c2ccccc2F)cc2nc(C3=NOC4(CCCCC4)C3)[nH]c12,,CCO,,,,val
US04284643,Cc1ccc(OC(F)F)cc1.O=C1CCC(=O)N1Br>>FC(F)Oc1ccc(CBr)cc1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US06060484,NCC(c1ccccc1)c1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C=NCC(c1ccccc1)c1ccccc1,,ClCCl,,,,val
US20160207883A1,CCOC(=O)CCCOCCOc1ccc(Nc2cc(C(N)=O)ccc2C(C)=O)cc1>>CC(=O)c1ccc(C(N)=O)cc1Nc1ccc(OCCOCCCC(=O)O)cc1,,C1CCOC1,,CO,[Li+].[OH-],val
US20100144741A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(N)cc1)[C@H](O)CNC1(c2cccc(C(C)(C)C)c2)CCCCC1.Cl.Fc1ccc(-c2cc(Cl)ncn2)cc1>>CC(C)(C)c1cccc(C2(NC[C@@H](O)[C@@H](N)Cc3ccc(Nc4cc(-c5ccc(F)cc5)ncn4)cc3)CCCCC2)c1.Cl,,CC(C)O,,,,val
US04882338,CC(C)(C)C(=O)OCCl.COc1cc2ccnc(CSc3nc4ccccc4[nH]3)c2cc1OCC(F)(F)F>>COc1cc2ccnc(CSc3nc4ccccc4n3COC(=O)C(C)(C)C)c2cc1OCC(F)(F)F,,CN(C)C=O,,[H-].[Na+],,val
US03933860,COc1ccccc1NC1COC(=O)C1.O=C(Cl)CCl>>COc1ccccc1N(C(=O)CCl)C1COC(=O)C1,,CCOC(C)=O,O,c1ccncc1,,val
US20120316193A1,C1CCNCC1.Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)CBr>>Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)CN1CCCCC1,,ClCCl,,CCN(CC)CC,,val
US20060235024A1,C#CCBr.CCOC(=O)N1CCNCC1>>C#CCN1CCN(C(=O)OCC)CC1,,CC#N,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20150094338A1,CC(C)C[C@H](N[S@@](=O)C(C)(C)C)c1ccc(-c2ccc(C(F)(F)F)cn2)cc1>>CC(C)C[C@H](N)c1ccc(-c2ccc(C(F)(F)F)cn2)cc1,,CO,,CCOCC,Cl,val
US20100022538A1,COc1ccc(C=O)cc1.NN.O=c1nc(Cl)c(F)c[nH]1>>COc1ccc(/C=N/Nc2nc(=O)[nH]cc2F)cc1,,CCO,,CCN(CC)CC,O,val
US06242443B1,CCOC(=O)Cc1ccc2c(c1)NC(NC(C)C)=NS2(=O)=O.N>>CC(C)NC1=NS(=O)(=O)c2ccc(CC(N)=O)cc2N1,,CO,,[C-]#N.[Na+],,val
US20140163033A1,BrCc1ccccc1.O=C(O)c1[nH]ccc1Cl>>O=C(OCc1ccccc1)c1[nH]ccc1Cl,,CN(C)C=O,,CCN(CC)CC,,val
US20120283297A1,CC(C)Oc1ccc(C(=O)O)cc1Cl.CCOC(=O)CCCn1ncc2cc(C(=N)NO)c(C)cc21>>CCOC(=O)CCCn1ncc2cc(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)c(C)cc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130059834A1,C/C(=N\S(=O)C(C)(C)C)C1CC1.[Li]C>>CC(C)(NS(=O)C(C)(C)C)C1CC1,,Cc1ccccc1,,C[Al](C)C,,val
US20160136230A1,CC(C)(C)OC(=O)COCCOCCOCCO.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCCOCCOCCOCC(=O)OC(C)(C)C)cc1,,c1ccncc1,,,,val
US20010008903A1,CCOC(=O)c1cc2c(C=O)c(O)ccc2[nH]1.Cc1ccc(S(=O)(=O)OC[C@H]2CO2)cc1>>CCOC(=O)c1cc2c(C=O)c(OC[C@H]3CO3)ccc2[nH]1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090197862A1,COC(=O)c1cccc(B(O)O)c1.Nc1ncc(Br)cc1-c1nc2ccccc2s1>>COC(=O)c1cccc(-c2cnc(N)c(-c3nc4ccccc4s3)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060122391A1,CONc1nc(C(c2ccccc2)(c2ccccc2)c2ccccc2)nc2c1nc(CCCN=[N+]=[N-])n2COCP(=O)(OC(C)C)OC(C)C>>CONc1nc(C(c2ccccc2)(c2ccccc2)c2ccccc2)nc2c1nc(CCCN)n2COCP(=O)(OC(C)C)OC(C)C,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050004143A1,O=P(Cl)(Cl)Cl.Oc1nc(-c2cc(Cl)ccc2F)nc2c1OCC2>>Fc1ccc(Cl)cc1-c1nc(Cl)c2c(n1)CCO2,,ClCCl,,O=C([O-])O.[Na+],,val
US20150119380A1,Cc1cn2nc(CC(=O)OC(C)(C)C)ccc2n1.O=Cc1ccc(Br)cc1O>>Cc1cn2nc(-c3cc4ccc(Br)cc4oc3=O)ccc2n1,,CCO,O,C1CCNCC1,CC(=O)O,val
US20080096875A1,Nc1cccc(OCc2ccccc2)c1.S=C=NCCCl>>S=C(NCCCl)Nc1cccc(OCc2ccccc2)c1,,ClCCl,,,,val
US20090191183A1,O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OC1CCCC1.c1ccncc1>>NC(=O)OC1CCCC1,,Cc1ccccc1,,,,val
US20110178151A1,CCCCCCCC/C=C\CCCCCCCC(=O)O>>CCCCCCCCCCCCCCCCCC(=O)O,[Pd],CCOC(C)=O,,,,val
US05030654,CC(C)(C)OC(=O)CC(=O)OCc1ccccc1.CSCCCl>>CSCCC(C(=O)OCc1ccccc1)C(=O)OC(C)(C)C,,CN(C)C=O,,O,[H-].[Na+],val
US20030060466A1,N#Cc1c(Cl)nc(NCCO)nc1NCC1CC1.c1ccc(C2CCNCC2)cc1>>N#Cc1c(NCC2CC2)nc(NCCO)nc1N1CCC(c2ccccc2)CC1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US04645771,C1=CCNCC1.CC(=O)Oc1ccc(C=O)cc1OC(C)=O>>Oc1ccc(CN2CC=CCC2)cc1O,,CO,,,,val
US20130045942A1,NO.Nc1cccc(C=O)c1>>Nc1cccc(C=NO)c1,,CCO,,Cl,CC(=O)[O-].[Na+],val
US04208510,CCO.O=C1OC2(CC(c3ccc(Cl)cc3Cl)=NO2)c2ccccc21>>CCOC(=O)c1ccccc1-c1cc(-c2ccc(Cl)cc2Cl)no1,,CCCCCC,,O=S(=O)(O)O,,val
US20100273770A1,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1cccc(Br)c1O>>CCOC(=O)/C=C/c1cccc(Br)c1O,,ClCCl,,,,val
US04840887,O=[N+]([O-])c1ccc(S(=O)(=O)Cl)c([N+](=O)[O-])c1.Sc1nnnn1-c1ccccc1>>O=[N+]([O-])c1ccc(S(=O)(=O)Sc2nnnn2-c2ccccc2)c([N+](=O)[O-])c1,,C1CCOC1,,CCN(CC)CC,,val
US04508649,C[C@@H](OC(=O)OCc1ccc([N+](=O)[O-])cc1)[C@H]1C(=O)N(C(O)C(=O)OCc2ccc([N+](=O)[O-])cc2)[C@@H]1SC(=O)CO[Si](C)(C)C(C)(C)C.O=S(Cl)Cl>>C[C@@H](OC(=O)OCc1ccc([N+](=O)[O-])cc1)[C@H]1C(=O)N(C(Cl)C(=O)OCc2ccc([N+](=O)[O-])cc2)[C@@H]1SC(=O)CO[Si](C)(C)C(C)(C)C,,C1CCOC1,,c1ccncc1,,val
US20090197201A1,OCCCCCCCCCBr.Oc1ccc(C(F)(F)F)cc1>>FC(F)(F)c1ccc(OCCCCCCCCCBr)cc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120196894A1,Nc1ccccc1.O=C1CCC[C@H]2CCCC[C@]12O>>O[C@]12CCCC[C@@H]1CCC[C@H]2Nc1ccccc1,,CC(=O)O,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080311179A1,C=O.CC(=O)c1ccc(Cl)cc1.CNC.Cl>>CN(C)CCC(=O)c1ccc(Cl)cc1.Cl,,CC(C)=O,CCO,Cl,,val
US20150266879A1,CCN(C(=O)OC(C)(C)C)[C@@H](C)C(=O)N[C@H](C(=O)N1c2ncccc2C[C@H]1C(=O)Nc1ccccc1)C1CCCCC1>>CCN[C@@H](C)C(=O)N[C@H](C(=O)N1c2ncccc2C[C@H]1C(=O)Nc1ccccc1)C1CCCCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ncccc3C(=O)O)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3ncccc3C(=O)O)c2)=C(C)C1=O,,CO,Cl,O=C([O-])O.[Na+],,val
US20050131017A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](CC(Cc1ccc(-c2ccccn2)cc1)C(=O)O)O[Si](C)(C)C(C)(C)C.OCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CC(Cc1ccc(-c2ccccn2)cc1)NC(=O)OCc1ccccc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20130331419A1,CCC(c1ccc(Cl)cc1)(n1ccc2c(NS(C)(=O)=O)cccc21)C(C)(O)CC#N>>CCC(C(C)=CC#N)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20030125227A1,CC(C)(C)O.CCCCCCCCCCCCCC(=O)Cl.CCCCCCCCCCCCCC(=O)N[C@@H](C)C(=O)O.C[C@H](N)C(=O)O.[OH-]>>CCCCCCCCCCCCCC(=O)N[C@@H](C)C(=O)O.OCCN(CCO)CCO,,CC(C)(C)O,O,O=S(=O)(O)O,,val
US20150018345A1,C=CC[Mg]Br.O=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>C=CCC(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,C1CCOC1,,[Cl-].[NH4+],,val
US05328917,CN1CC[C@@H](c2ccc([N+](=O)[O-])cc2)[C@H](COc2ccc3c(c2)OCO3)C1.Cl>>Cl.O=[N+]([O-])c1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1,,ClCCCl,,CC(Cl)OC(=O)Cl,,val
US20090029994A1,CCCCN(CC)c1ccc(C(F)(F)F)cc1C=O.NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CCCCN(CC)c1ccc(C(F)(F)F)cc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,ClCCCl,ClCCl,CC(=O)O,[Na+].[OH-],val
US20160009744A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1sc(C2OCCO2)cc1C1NCCc2ccc(Cl)cc21>>Cc1sc(C2OCCO2)cc1C1c2cc(Cl)ccc2CCN1C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20100056374A1,COc1ccc(CC#N)c(C)c1.Cl>>COc1ccc(CCN)c(C)c1.Cl,[Pd],CCO,,[H][H],,val
US20100093991A1,C[C@]1(OCc2ccccc2)C(=O)O[C@H](COCc2ccccc2)[C@H]1OCc1ccccc1>>C[C@]1(OCc2ccccc2)C(O)O[C@H](COCc2ccccc2)[C@H]1OCc1ccccc1,,Cc1ccccc1,,CCOC(C)=O,,val
US04578397,NC(=O)CCl.O=C1CC2Cc3c(Cl)cccc3C2N1>>NC(=O)CN1C(=O)CC2Cc3c(Cl)cccc3C21,,CN(C)C=O,,Cl,[H-].[Na+],val
US05045558,CCCC(c1ccc(C(=O)O)cc1)n1ccnc1.CN(C)C(OC(C)(C)C)OC(C)(C)C>>CCCC(c1ccc(C(=O)OC(C)(C)C)cc1)n1ccnc1,,CCOCC,Cc1ccccc1,O,O=C([O-])[O-].[K+].[K+],val
US04018785,CCOC(=O)Cc1ccc(Nc2nccs2)c(Cl)c1.CI>>CCOC(=O)Cc1ccc(Nc2scc[n+]2C)c(Cl)c1.[I-],,CCO,,,,val
US20070167452A1,CCOC(=O)C1CCC(=O)CC1.C[SiH](C)OCCc1ccccc1>>CCOC(=O)[C@@H]1CC[C@H](OCCc2ccccc2)CC1,,ClCCl,,C[Si](C)(C)I,,val
US04259329,C[C@H]1CC(=O)C[C@]23CCN(CC4CCC4)[C@H](Cc4ccc(O)cc42)[C@H]13.O=C(O)[C@@H](O)[C@H](O)C(=O)O>>C[C@H]1CC(=O)C[C@]23CCN(CC4CCC4)[C@H](Cc4ccc(O)cc42)[C@H]13.O=C(O)C(O)C(O)C(=O)O,,CCO,,,,val
US04605785,CCC(O)(c1ccc(O)cc1)c1cccc(C(F)(F)F)c1.CCN(CC)C(=O)CCl>>CCN(CC)C(=O)COc1ccc(C(O)(CC)c2cccc(C(F)(F)F)c2)cc1,,CC(C)=O,,[I-].[K+],,val
US04803223,O=C(NCCBr)Nc1ccc(N(CCBr)CCBr)cc1>>Nc1ccc(N(CCBr)CCBr)cc1,,CCOCC,,CCN(CC)CC,,val
US20100105900A1,CI.Cc1cccc(C#Cc2ccc(S(=O)(=O)N[C@H](CC(=O)OCc3ccccc3)CN(C)C)s2)c1>>Cc1cccc(C#Cc2ccc(S(=O)(=O)N[C@H](CC(=O)OCc3ccccc3)C[N+](C)(C)C)s2)c1.[I-],,ClCCl,,,,val
US20030232883A1,Nc1ccc(C=Cc2ccc(F)cc2)cc1>>Nc1ccc(CCc2ccc(F)cc2)cc1,[Pd],C1CCOC1,,,,val
US20050239832A1,O=C1COCc2ccc(Br)cc21>>OC1=COCc2ccc(Br)cc21,,CCO,,[BH4-].[Na+],,val
US20050250753A1,O=C(O)c1cc(Br)ccc1I>>OCc1cc(Br)ccc1I,,C1CCOC1,,CSC,,val
US20100093703A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=[N+]([O-])c1ccc2c(c1)CCN2c1ncc[nH]1>>CC(C)(C)OC(=O)n1ccnc1N1CCc2cc([N+](=O)[O-])ccc21,,C1CCOC1,,,,val
US06440588B1,CC(=O)CC(=O)c1ccccc1.N#C/C(N)=C(/N)C#N>>CC1=CC(O)(c2ccccc2)NC(C#N)C(C#N)=N1,,c1ccccc1,,Cl,,val
US04294843,Nc1ccccc1SCc1ncon1.O=C(Cl)c1ccc(Cl)cc1>>O=C(Nc1ccccc1SCc1ncon1)c1ccc(Cl)cc1,,O,,[Na+].[OH-],,val
US20080045511A1,CN(C)C=O.N#Cc1cc(Cl)cc(Oc2c(Br)ccc(Br)c2F)c1>>N#Cc1cc(Cl)cc(Oc2c(Br)ccc(C=O)c2F)c1,,C1CCOC1,Cc1ccccc1,CC(C)[Mg]Cl,,val
US20070093526A1,CC(C)(C)OC(=O)N1CCC(NCc2scnc2Cl)CC1.CC(C)C=O>>CC(C)CN(Cc1scnc1Cl)C1CCN(C(=O)OC(C)(C)C)CC1,,ClCCCl,,CC(=O)O,[Na+].[OH-],val
US04722929,COc1ccc(-c2nc3ncnc(Cl)c3[nH]2)c(OC)c1.[OH-]>>COc1ccc(-c2nc3nc[nH]c(=O)c3[nH]2)c(OC)c1,,[Na+],[OH-],CC(=O)O,,val
US20090186886A1,COC1CCNCC1.O=C1c2ccccc2C(=O)N1CCCBr>>COC1CCN(CCCN2C(=O)c3ccccc3C2=O)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060276654A1,Cl.O=C(O)[C@@H]1CCCCN1>>Cl.O=C(O)[C@@H]1CCCCN1,,CO,,,,val
US06107495,Cl[Mg]Cc1ccccc1.O=C(Cl)CCCCCl>>O=C(CCCCCl)Cc1ccccc1,Cl[Cu],C1CCOC1,,Cl,,val
US20080255160A1,C#C[Si](C)(C)C.Cc1c(Nc2ccc(I)cc2F)c2c(=O)n(C[C@@H](O)CO)cnc2n(C)c1=O>>C#Cc1ccc(Nc2c(C)c(=O)n(C)c3ncn(C[C@@H](O)CO)c(=O)c23)c(F)c1,I[Cu]I,C1CCOC1,,CCN(CC)CC,,val
US20030176454A1,Cc1ncc(-c2cccc(N)c2)n1C.O=C(O)c1cccc(Br)c1F>>Cc1ncc(-c2cccc(NC(=O)c3cccc(Br)c3F)c2)n1C,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20090270435A1,COC(=O)c1cccc(C(C)=O)c1.COC(OC)N(C)C>>COC(=O)c1cccc(C(=O)C=CN(C)C)c1,,Cc1ccccc1,,CO,,val
US06541647B2,CC(C)(C)[Si](C)(C)OC1CCC(COc2ccc(F)cc2)O1.O=S(=O)(O)c1ccccc1>>O=S(=O)(c1ccccc1)C1CCC(COc2ccc(F)cc2)O1,,ClCCl,ClCCl,[Ca+2].[Cl-].[Cl-],,val
US20070259851A1,CC(C)(C)OC(=O)N1CCC(n2ccn(-c3ccccc3F)c2=O)CC1.Cl>>Cl.O=c1n(-c2ccccc2F)ccn1C1CCNCC1,,CCOC(C)=O,,C1COCCO1,,val
US06759546B1,CC(C)OB(OC(C)C)OC(C)C.CCCOc1c(Br)cc(C(C)C)cc1C(C)C>>CCCOc1c(B(O)O)cc(C(C)C)cc1C(C)C,,C1CCOC1,,Cl,[Li]CCCC,val
US05308852,Oc1ccc2c(-c3ccccc3)cc(CCl)cc2c1.Sc1ccccc1>>Oc1ccc2c(-c3ccccc3)cc(CSc3ccccc3)cc2c1,,CN(C)C=O,,O,[H-].[Na+],val
US20160251382A1,CC#CC(C)O.CCCC[SnH](CCCC)CCCC>>C/C=C(/C(C)O)[Sn](CCCC)(CCCC)CCCC,,ClCCl,,,,val
US20060167315A1,Cc1cc(C(F)(C(F)(F)F)C(F)(F)F)ccc1NC(=O)c1cccc(I)c1C(=O)O>>Cc1cc(C(F)(C(F)(F)F)C(F)(F)F)ccc1N=C1OC(=O)c2c(I)cccc21,,COC(C)(C)C,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20090062274A1,COC(C)(OC)N(C)C.NC(N)=S>>C/C(=N\C(N)=S)N(C)C,,ClCCl,,,,val
US20110245236A1,CC(C)(C)OC(=O)NCCc1ccc(C(=O)NN)cc1.ClC1=Nc2cccnc2Nc2ccccc21>>CC(C)(C)OC(=O)NCCc1ccc(-c2nnc3n2-c2cccnc2Nc2ccccc2-3)cc1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20090274632A1,Cc1noc(C)c1Cn1cc(N2C(=O)CN(Cc3ccccc3[N+](=O)[O-])C2=O)cn1>>Cc1noc(C)c1Cn1cc(N2C(=O)CN(Cc3ccccc3N)C2=O)cn1,[Pd],CCO,,,,val
US20060046980A1,C=C(C)c1cc(C(O)c2c(C)cc(O[Si](C(C)C)(C(C)C)C(C)C)cc2C)ccc1F>>Cc1cc(O[Si](C(C)C)(C(C)C)C(C)C)cc(C)c1Cc1ccc(F)c(C(C)C)c1,[Pd],CC(=O)O,CCO,,,val
US20070219234A1,c1csc(N2CCCNCC2)n1>>c1csc(N2CCCNCC2)n1,,[Na+],[OH-],Cl,Cl,val
US04548932,CC(C)(C)OC(=O)CN1C(=O)[C@@H](N)COc2ccccc21.CCOC(=O)C(=O)CCCCCC1CCN(C(=O)OCc2ccccc2)CC1>>CCOC(=O)[C@@H](CCCCCC1CCN(C(=O)OCc2ccccc2)CC1)N[C@H]1COc2ccccc2N(CC(=O)OC(C)(C)C)C1=O,,CCO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20040116518A1,CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3cccc(C(=O)O)c3)c([N+](=O)[O-])c2)CC1>>CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3cccc(CO)c3)c([N+](=O)[O-])c2)CC1,,C1CCOC1,,CCN(CC)CC,CCOC(=O)Cl,val
US20060142357A1,CC(C)(C)OC(=O)N1CCC(CC2(C)SC(N[C@H]3CC4CCC3C4)=NC2=O)CC1>>CC1(CC2CCNCC2)SC(N[C@H]2CC3CCC2C3)=NC1=O,,CCOC(C)=O,,Cl,,val
US20120309738A1,CNc1cc(N2CCC(C(F)(F)F)CC2)c(Cl)cc1N.O=C(NCc1ccc(C(F)(F)F)c(N=C=S)c1)C1(C(F)(F)F)CC1>>Cn1c(Nc2cc(CNC(=O)C3(C(F)(F)F)CC3)ccc2C(F)(F)F)nc2cc(Cl)c(N3CCC(C(F)(F)F)CC3)cc21,,CN(C)C=O,,CC(C)N=C=NC(C)C,,val
US20100240702A1,C=C(C)n1c(=O)[nH]c2ccccc21.Cc1cc2cccc(CO)c2n1C>>C=C(C)n1c(=O)n(Cc2cccc3cc(C)n(C)c23)c2ccccc21,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060189606A1,CCOc1ccc2c(C#N)c(-c3ccc(N)cc3)n(CC)c2c1.O=C=NC(=O)CCl>>CCOc1ccc2c(C#N)c(-c3ccc(N4CC(=O)NC4=O)cc3)n(CC)c2c1,,C1COCCO1,,C1CCC2=NCCCN2CC1,,val
US05495020,CCOC(=O)c1cn(C2CC2)c2c(F)c(F)c(F)c(CC)c2c1=O>>CCc1c(F)c(F)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1,,CC(=O)O,,Cl,O,val
US20070099873A1,CC(C)COC(=O)NC1CCNCC1.Clc1cc2ccccc2c(Cl)n1>>CC(C)COC(=O)NC1CCN(c2nc(Cl)cc3ccccc23)CC1,,O,,CCN(CC)CC,CN(C)C=O,val
US20110098324A1,CC(C)CN.CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(Cc2ccccc2Cl)c1=O>>CC(C)CNC(=O)c1c(O)c(C(=O)NCC(=O)O)c(=O)n(Cc2ccccc2Cl)c1O,,ClC(Cl)Cl,,,,val
US20070149542A1,COCCBr.CS(=O)(=O)c1cccc(C2CCNCC2)c1F>>COCCN1CCC(c2cccc(S(C)(=O)=O)c2F)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100311750A1,CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nn[nH]n2)CN1C(=O)OC(C)(C)C.CI>>CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)CN1C(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020193614A1,CC(C)(C)OC(=O)NC[C@@H](CO)NC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NC[C@H](N)CO,[Pd],C1COCCO1,CO,,,val
US20120122900A1,C[C@@H]1[C@H](c2c(F)ccc(F)c2F)C[C@H](NC(=O)OC(C)(C)C)C(=O)N1CC(F)(F)F.Cl>>C[C@@H]1[C@H](c2c(F)ccc(F)c2F)C[C@H](N)C(=O)N1CC(F)(F)F.Cl,,CCOC(C)=O,,,,val
US20030092677A1,Cc1ccc(-c2ccc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])c2)cc1>>Cc1ccc(-c2ccc(NC(=O)OC(C)(C)C)c(N)c2)cc1,[Pd],,,,,val
US20100016368A1,CCOC(=O)Cn1ncc2c1CCC[C@H]2N.O=S(=O)(Cl)c1cc(Br)cc(C(F)(F)F)c1>>CCOC(=O)Cn1ncc2c1CCC[C@H]2NS(=O)(=O)c1cc(Br)cc(C(F)(F)F)c1,CN(C)c1ccncc1,C1CCOC1,,,,val
US05760032,CCOC(=O)Cn1c(C(=O)NCc2nnc3n2-c2sc(CC)cc2C(c2ccccc2Cl)=NC3)cc2ccccc21>>CCc1cc2c(s1)-n1c(nnc1CNC(=O)c1cc3ccccc3n1CC(=O)O)CN=C2c1ccccc1Cl,,CO,,[Na+].[OH-],,val
US20040176433A1,C=O.Clc1ccc(-c2n[nH]c(C3CCNCC3)c2-c2ccncc2)cc1>>CN1CCC(c2[nH]nc(-c3ccc(Cl)cc3)c2-c2ccncc2)CC1,,O=CO,,Cl,,val
US06218431B1,CC(C)C=Cc1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccc(F)cc1>>CC(C)CCc1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccc(F)cc1,,CCCCCC,CCOC(C)=O,,,val
US20080039494A1,Fc1ccc([Mg]Br)cc1.O=C1CCCc2cccnc21>>OC1(c2ccc(F)cc2)CCCc2cccnc21,,C1CCOC1,,,,val
US20130267509A1,Cc1ccccc1C(=O)Cl.Oc1ccccc1>>Cc1ccccc1C(=O)Oc1ccccc1,,C1CCOC1,,O,[H-].[Na+],val
US05028602,CN1CCc2c(Cl)sc(Cl)c2C(c2ccccc2)C1>>CN1CCc2c(csc2Cl)C(c2ccccc2)C1,[Pd],CC(=O)O,,,,val
US06313153B1,COC(=O)CCl.O=C(/C=C/c1cccnc1)NCCc1cccc(O)c1>>COC(=O)COc1cccc(CCNC(=O)/C=C/c2cccnc2)c1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20070093545A1,CC(=O)C(C)(O)C1=CCCCC1.COC(=O)C(OC)(OC)OC>>CC1(C2=CCCCC2)OC(C(=O)O)=CC1=O,,C1CCOC1,,[H-].[Na+],,val
US20070213339A1,CCOC(=O)c1cn(-c2ccc(CN3CCCC3)cc2)c2c(C#N)c(N3CCN(c4ccccn4)CC3)c(F)cc2c1=O>>N#Cc1c(N2CCN(c3ccccn3)CC2)c(F)cc2c(=O)c(C(=O)O)cn(-c3ccc(CN4CCCC4)cc3)c12,,CO,,Cl,[Na+].[OH-],val
US20140330026A1,CCOC(=O)C(C)C(=O)OCC.O=[N+]([O-])c1cc(F)c(F)c(F)c1>>CCOC(=O)C(C)(C(=O)OCC)c1c(F)cc([N+](=O)[O-])cc1F,,CN(C)C=O,,[Na+].[OH-],,val
US20140066424A1,Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1cccc(N2CCNCC2)c1.O=C(O)CO>>Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1cccc(N2CCN(C(=O)CO)CC2)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100298384A1,CC(C)(C)OC(=O)NC[C@H]1CN(c2ccc(-c3nc(Cn4ccnc4)cs3)c(F)c2)C(=O)O1.CO.S=C(Cl)Cl>>COC(=S)NC[C@H]1CN(c2ccc(-c3nc(Cn4ccnc4)cs3)c(F)c2)C(=O)O1,,CO,ClCCl,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20080255124A1,N#Cc1ccc(N(CCO)CC(F)(F)F)cc1C(F)(F)F.O=c1cc[nH]cn1>>N#Cc1ccc(N(CCOc2ccncn2)CC(F)(F)F)cc1C(F)(F)F,,COCCOC,,,,val
US20030162795A1,CC(C)=O.Clc1ccnc2cc(-c3nccs3)sc12>>CC(C)(O)c1cnc(-c2cc3nccc(Cl)c3s2)s1,,C1CCOC1,O,CC(C)NC(C)C,[Li]CCCC,val
US20060094764A1,CCOC(=O)C(F)(F)F.Cc1ccc(C)c(CC#N)c1>>Cc1ccc(C)c(C(C#N)C(=O)C(F)(F)F)c1,,CCO,,O,CC(C)(C)[O-].[K+],val
US20100010035A1,COCCOCN(c1noc(C)c1C)S(=O)(=O)c1sc(C)cc1-c1ccc(Cn2c(=O)ccc3c(C)nc(C)cc32)cc1OCC(C)C>>Cc1cc2c(ccc(=O)n2Cc2ccc(-c3cc(C)sc3S(=O)(=O)Nc3noc(C)c3C)c(OCC(C)C)c2)c(C)n1,,CCO,,Cl,,val
US07655657B2,O=C(O)/C=C/C(=O)O.c1cc2cc(-c3ccc(OC4CC5CCN4CC5)cc3)ccc2[nH]1>>O=C(O)/C=C/C(=O)O.c1cc2cc(-c3ccc(OC4CN5CCC4CC5)cc3)ccc2[nH]1,,CCO,CCOC(C)=O,,,val
US20110046133A1,CCOP(=O)(/C=C/c1cc(C)c(-c2nc3ccc(C(=O)Nc4ccc5ccccc5n4)cc3[nH]2)c(C)c1)OCC>>CCOP(=O)(CCc1cc(C)c(-c2nc3ccc(C(=O)Nc4ccc5ccccc5n4)cc3[nH]2)c(C)c1)OCC,[Pd],CCO,,,,val
US20050101592A1,CC(=O)OC(C)=O.O=C(O)c1nn(-c2ccccc2Cl)c(-c2ccc(Cl)cc2)c1O>>CC(=O)Oc1c(C(=O)O)nn(-c2ccccc2Cl)c1-c1ccc(Cl)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110257165A1,BrCCBr.COc1cccc(-c2n[nH]c(S)c2-c2ccncc2)c1>>COc1cccc(-c2nn3c(c2-c2ccncc2)SCC3)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090253749A1,O=C1C=C(N(Cc2ccc(Cl)nc2)CC(F)F)CO1.O=C1CCC(=O)N1Br>>O=C1OCC(N(Cc2ccc(Cl)nc2)CC(F)F)=C1Br,,CC#N,,CCN(CC)CC,,val
US04126681,CC(=O)Oc1ccccc1C(=O)O.CC(O)CO.CC(O)CO.CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)CO.CCO.CCO>>CC(O)CCO.CCC(O)CO.OCCCCO.OCCCO,,CCO,,,,val
US20110172095A1,O=Cc1ccc(F)cc1.OCCO>>Fc1ccc(C2OCCO2)cc1,,O,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US20090291951A1,CS(=O)(=O)OCc1ccnc(N)n1.O=C(O)c1cccnc1S>>Nc1nccc(CSc2ncccc2C(=O)O)n1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20140235628A1,CC(C)(C)OC(=O)COc1ccc2c(c1)COC2=O>>O=C(O)COc1ccc2c(c1)COC2=O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080112951A1,CC(=O)OC[C@H]1O[C@@H](O[C@H]2[C@H](O)O[C@@H](C)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)[C@H](NC(=O)C(Cl)(Cl)Cl)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.N#CC(Cl)(Cl)Cl>>CC(=O)OC[C@H]1O[C@@H](O[C@H]2[C@H](OC(=N)C(Cl)(Cl)Cl)O[C@@H](C)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)[C@H](NC(=O)C(Cl)(Cl)Cl)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US20050043372A1,C1COCCN1.CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1nnc(C(C)(C)C=O)s1>>CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1nnc(C(C)(C)CN2CCOCC2)s1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20030166639A1,Cc1ncccc1-c1cccc(C(=O)CC(=O)Nc2cc(F)ccc2NC(=O)OC(C)(C)C)c1>>Cc1ncccc1-c1cccc(C2=Nc3ccc(F)cc3NC(=O)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110301161A1,CC(=O)O.CC(C)(C)n1c(-c2ccccc2C(=N)NO)nc2cc(-c3cnc(N)nc3)ccc21>>Cc1nc(-c2ccccc2-c2nc3cc(-c4cnc(N)nc4)ccc3n2C(C)(C)C)no1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05607950,O=S(Cl)Cl.OCCC1CCCCN1Cc1ccccc1>>Cl.ClCCC1CCCCN1Cc1ccccc1,,ClC(Cl)Cl,,,,val
US20070185128A1,CC(C)(CC(=O)N(CC1CCN(C(=O)OC(C)(C)C)CC1)C[C@H]1C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N1Cc1ccc(-c2ccccc2)cc1)NC(=O)OC(C)(C)C>>CC(C)(N)CC(=O)N(CC1CCNCC1)C[C@H]1C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N1Cc1ccc(-c2ccccc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04340595,COc1cccc2c1CCCC(=O)N2>>O=C1CCCc2c(O)cccc2N1,,CN(C)C=O,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04663410,COC(CN)OC.O=C1C=CC(=O)O1>>COC(CNC(=O)/C=C\C(=O)O)OC,,ClCCl,,,,val
US05008276,N#Cc1cccnc1Cl.Oc1cccc(Oc2ccccc2)c1>>N#Cc1cccnc1Oc1cccc(Oc2ccccc2)c1,[Cu],CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150353535A1,CCOC(=O)[C@H]1CCC(=O)C[C@H]1C.c1cscn1>>CCOC(=O)[C@H]1CCC(O)(c2nccs2)C[C@H]1C,,C1CCOC1,,[Li]CCCC,,val
US03931328,BrCCCBr.CCO.CCOC1C(=O)C(=C=O)c2ccccc21>>CCOC(=O)C1(CCCBr)C(=O)Cc2ccccc21,,O,,[Na+].[OH-],,val
US20110065709A1,C=CCOc1cc(N2C(=O)c3ccccc3C2=O)n[nH]1>>C=CCOc1cc(N)n[nH]1,,CCO,,NN,,val
US20050143422A1,CCOC(=O)c1oc2cccc(C#N)c2c1C>>Cc1c(C(=O)O)oc2cccc(C#N)c12,,C1CCOC1,,CO,[Li+].[OH-],val
US20060083681A1,COc1nc(CCCCCCCCCO)c(C)c(OCc2ccccc2)c1OC.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1nc(CCCCCCCCCOS(=O)(=O)c2ccc(C)cc2)c(C)c(OCc2ccccc2)c1OC,,O,,CCN(C(C)C)C(C)C,ClCCl,val
US03992441,O=C(O)c1cc(S(=O)(=O)N2CCC(CCl)CC2)ccc1Cl>>C=C1CCN(S(=O)(=O)c2ccc(Cl)c(C(=O)O)c2)CC1,,O,,Cl,[Na+].[OH-],val
US05278332,CCO.Cc1ccc(S(=O)(=O)O)cc1.O.OC1[C@@H](O)[C@@H](OCc2ccccc2)C(OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O>>CC1(C)C2CCC1(C)C(C(=O)O)C2,[Pd],O,,,,val
US20020042427A1,CN(C)S(=O)(=O)c1ccc2c(c1)CC(=O)N2.O=Cc1[nH]cc2c1CCNC2=O>>CN(C)S(=O)(=O)c1ccc2c(c1)C(=Cc1[nH]cc3c1CCNC3=O)C(=O)N2,,CCO,,C1CCNCC1,,val
US20090069326A1,C=CCCC(=O)N1C(=O)OC[C@H]1Cc1ccccc1.Clc1cc(OCc2ccccc2)cc(Cl)c1CBr>>C=CC[C@@H](Cc1c(Cl)cc(OCc2ccccc2)cc1Cl)C(=O)N1C(=O)OC[C@H]1Cc1ccccc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US04663341,ClCc1ccccc1.O=Cc1ccc(Cl)c(Cl)c1>>OC(Cc1ccccc1)c1ccc(Cl)c(Cl)c1,II,CCOCC,,[Mg],,val
US20120208817A1,COC(=O)c1ccc(C=O)cc1C(F)(F)F.NC(N)=O.O=C(Cc1ccccc1)c1ccccc1>>COC(=O)c1ccc(C2NC(=O)NC(c3ccccc3)=C2c2ccccc2)cc1C(F)(F)F,,CCO,,Cl,,val
US20080096874A1,COC(=O)C1(C)CCN(c2ccc(NC(=O)c3nnc(Nc4ccc(F)c(F)c4)o3)cn2)CC1>>CC1(C(=O)O)CCN(c2ccc(NC(=O)c3nnc(Nc4ccc(F)c(F)c4)o3)cn2)CC1,,CO,,[Na+].[OH-],,val
US20100216746A1,CCOC(=O)c1cc2cc(NC(=O)OC(C)(C)C)ccc2[nH]1.O=C1CCC(=O)N1Cl>>CCOC(=O)c1[nH]c2ccc(NC(=O)OC(C)(C)C)cc2c1Cl,,ClCCl,,CO,,val
US20150031685A1,CNC(CN1CC[C@H](F)C1)c1cccc(OCC(=O)OC(C)(C)C)c1.O=C(O)Cc1ccc2c(c1)NC(=O)C2>>CN(C(=O)Cc1ccc2c(c1)NC(=O)C2)[C@H](CN1CC[C@H](F)C1)c1cccc(OCC(=O)OC(C)(C)C)c1,,CN(C)C=O,ClCCl,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20120142686A1,C=C(C)c1ccc(-n2nc3cc(NS(C)(=O)=O)c(C4CC4)cc3c2C(=O)NC)cc1>>CNC(=O)c1c2cc(C3CC3)c(NS(C)(=O)=O)cc2nn1-c1ccc(C(C)C)cc1,[Pd],CO,,,,val
US20050070562A1,CS(=O)(=O)c1ccc(Nc2ncnc(OC3CCNCC3)c2[N+](=O)[O-])cc1.O=C(Cl)c1cccnc1>>CS(=O)(=O)c1ccc(Nc2ncnc(OC3CCN(C(=O)c4cccnc4)CC3)c2[N+](=O)[O-])cc1,,CN(C)C=O,,CCN(CC)CC,,val
US20140073627A1,COc1cc(C)c(S(=O)(=O)N(Cc2nc(C(=O)N3CCNCC3)co2)C2CC2)c(C)c1.Cn1cncc1C=O>>COc1cc(C)c(S(=O)(=O)N(Cc2nc(C(=O)N3CCN(Cc4cncn4C)CC3)co2)C2CC2)c(C)c1,,ClCCCl,,CC(=O)O,,val
US05753595,Cn1c(C(F)(F)F)cc(=O)n(-c2c(F)cc(Cl)c3nc(Cl)oc23)c1=O.Oc1ccccc1>>Cn1c(C(F)(F)F)cc(=O)n(-c2c(F)cc(Cl)c3nc(Oc4ccccc4)oc23)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US04966967,CS(=O)(=O)Nc1ccc2c(c1)OCCNCCO2.O=C1CCCC1>>CS(=O)(=O)Nc1ccc2c(c1)OCCN(C1CCCC1)CCO2,,CO,,Cl,[BH3-]C#N.[Na+],val
US20060229309A1,CCCO[C@@H]1C[C@H]([C@@H](O[Si](C)(C)C(C)(C)C)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(OC(C)C)cc(N3CCCC3=O)c2)N(C(=O)OC(C)(C)C)C1>>CCCO[C@H]1CN[C@@H]([C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(OC(C)C)cc(N3CCCC3=O)c2)C1,O,Cl,,,,val
US04343741,CN(C)c1ccc(Br)cc1.[Li]CCCC>>[Li]c1ccc(N(C)C)cc1,,CCOCC,CCOCC,CCCCCC,,val
US20140057916A1,CCNC(=O)c1cn(C(C)c2ccc(C#N)cc2)c(C)c(Br)c1=O.OB(O)c1cccc(C(F)(F)F)c1>>CCNC(=O)c1cn(C(C)c2ccc(C#N)cc2)c(C)c(-c2cccc(C(F)(F)F)c2)c1=O,,CC#N,CO,O=C([O-])[O-].[K+].[K+],,val
US20090023720A1,CNc1nc2c(Cl)nc3ccccc3c2n1C.N>>CNc1nc2c(N)nc3ccccc3c2n1C,,CO,,,,val
US20040010037A1,CC#N.CCN(CC)CC.CN(C)C=O.N#Cc1ccc(O)cc1C#N>>C[C@H]1CN[C@H](C)CN1c1ccc(C#N)c(C#N)c1,,CC#N,,O=S(=O)(O)C(F)(F)F,,val
US20130324526A1,BrBr.COC(=O)C(C)c1c(F)cc2ncccc2c1F>>COC(=O)C(C)c1c(F)cc2ncc(Br)cc2c1F,,ClC(Cl)(Cl)Cl,,c1ccncc1,,val
US20090286777A1,CI.COC(=O)C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CN1C(=O)OC(C)(C)C>>COC(=O)C(C)[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CN1C(=O)OC(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120088755A1,Cc1cc(O)cc([N+](=O)[O-])c1N.Clc1cc(Cl)ncn1>>Cc1cc(Oc2cc(Cl)ncn2)cc([N+](=O)[O-])c1N,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050107402A1,CC(C)(C)OC(=O)CC#N.O=Cc1ccc(Br)cc1>>CC(C)(C)OC(=O)/C(C#N)=C/c1ccc(Br)cc1,,c1ccccc1,,,,val
US20120149684A1,CNOC.O=C(O)C1CCOCC1>>CON(C)C(=O)C1CCOCC1,,ClCCl,,Cl,O=C(n1ccnc1)n1ccnc1,val
US20160130237A1,CNc1cc(Nc2ccccc2[N+](=O)[O-])ncn1.COc1cc(OC)c(Cl)c(N=C=O)c1Cl>>COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3[N+](=O)[O-])ncn2)c1Cl,,C1CCOC1,CCOC(C)=O,O,[H-].[Na+],val
US20110306587A1,COc1ccc(CN)c(OC)c1.CS(=O)(=O)OCCC1(CCOS(C)(=O)=O)COC1>>COc1ccc(CN2CCC3(CC2)COC3)c(OC)c1,,CC#N,,CCN(CC)CC,,val
US20070072847A1,CCOC(=O)COC1CCN(C2CCN(C(=O)[C@@H](Cc3cc(C)c(O)c(C)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCC(OCC(=O)O)CC3)CC2)cc(C)c1O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US06306873B1,COc1ccc(SC(CCCCc2ccccc2)CC(=O)OC(C)(C)C)cc1OC1CCCC1>>COc1ccc(SC(CCCCc2ccccc2)CC(=O)O)cc1OC1CCCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140113882A1,N#Cc1ccnc2[nH]c(C(F)(F)F)cc12.NO>>N=C(NO)c1ccnc2[nH]c(C(F)(F)F)cc12,,CCO,,,,val
US20060106020A1,CC(C)(C)C(=O)Cn1c(=O)c2ccc(F)cc2c2cnccc21.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)C(=O)Cn1c(=O)c2ccc(F)cc2c2c[n+]([O-])ccc21,,ClCCl,,,,val
US20070106080A1,COc1ccc(NC(=O)C(F)(F)F)cc1.O=P(Cl)(Oc1ccccc1)Oc1ccccc1>>COc1ccc(N=C(Cl)C(F)(F)F)cc1,,CCOC(C)=O,,CC#N,CCN(CC)CC,val
US20050009900A1,C#CCCO.O=C(NCC1(O)CCCCCC1)c1cc(C=NO)ccc1Cl>>O=C(NCC1(O)CCCCCC1)c1cc(-c2cc(CCO)on2)ccc1Cl,CCN(CC)CC,ClCCl,O,[Na+].[O-]Cl,,val
US04902814,CC1(C)[C@H](/C=C(\Cl)C(F)(F)F)[C@@H]1C(=O)O.OCc1ccc(F)c(Cc2ccccc2)c1>>CC1(C)[C@H](/C=C(\Cl)C(F)(F)F)[C@@H]1C(=O)OCc1ccc(F)c(Cc2ccccc2)c1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150284405A1,COc1cc2c(=O)cc[nH]c2cc1I.O=C1CCC(=O)N1Cl>>COc1cc2c(=O)c(Cl)c[nH]c2cc1I,,CC(=O)O,,,,val
US20110105463A1,CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)NC4CCC(c5ccc(Cl)cc5)CC4)cc3)c(Cl)cc21>>O=C(NC1CCC(c2ccc(Cl)cc2)CC1)c1ccc(Oc2cc3c(cc2Cl)C(C(=O)O)CCO3)cc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20110136801A1,COCCc1nc2c(N)nc3ccccc3c2n1CCOCCN1C(=O)c2ccccc2C1=O>>COCCc1nc2c(N)nc3ccccc3c2n1CCOCCN,,CCO,,NN,O,val
US20040192921A1,N#Cc1ccccc1N1CCCCC1.O=CO>>O=Cc1ccccc1N1CCCCC1,[Ni],,,,,val
US20140031374A1,CS(=O)(=O)c1ccc(C(=O)O)cc1.Nc1ccccc1Cl>>CS(=O)(=O)c1ccc(C(=O)Nc2ccccc2Cl)cc1,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20100105905A1,CC(C)OC(=O)COc1cccc(C=O)c1.NO>>CC(C)OC(=O)COc1cccc(C=NO)c1,,CO,,Cl,c1ccncc1,val
US20060154922A1,O=C1CCCC(CO)N1.Oc1ccccc1>>O=C1CCCC(COc2ccccc2)N1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110263556A1,CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)Nc2cc(F)c(F)c(C(=O)O)c2)c1.Nc1ccc(Br)cc1>>CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)Nc2cc(F)c(F)c(C(=O)Nc3ccc(Br)cc3)c2)c1,,CN(C)C=O,,,,val
US20080293749A1,C1=Nc2ccccc2CN1.O=C1C=CC(=O)N1>>O=C1NCCC1N1C=Nc2ccccc2C1,,CN(C)C=O,,CCN(CC)CC,,val
US20040082542A1,O=[N+]([O-])c1ccc(F)cc1.Oc1ccc(Br)cc1>>O=[N+]([O-])c1ccccc1Oc1ccc(Br)cc1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20100048571A1,O=C(c1ccc(F)cc1)c1cncc(CO)c1.O=S(Cl)Cl>>O=C(c1ccc(F)cc1)c1cncc(CCl)c1,,CC#N,,,,val
US20080108624A1,CC(C)(C)OC(=O)N1CCC(CC2CCN(CC3CC3)CC2)CC1>>C1CC(CC2CCN(CC3CC3)CC2)CCN1,,C1COCCO1,Cl,,,val
US04002623,O=[N+]([O-])c1ccccc1NCCCN1CCCCC1>>Nc1ccccc1NCCCN1CCCCC1,,Cl,,CC(C)O,,val
US20090186879A1,COC(=O)c1ccc(OC)c([N+](=O)[O-])c1NCCCCl>>COC(=O)c1ccc(OC)c(N)c1NCCCCl,[Fe],CC(=O)O,,,,val
US20100120739A1,COC(OC)N(C)C.Cc1ncc(Br)cc1[N+](=O)[O-]>>Brc1cnc2cc[nH]c2c1,[Fe],CN(C)C=O,,CO,,val
US20130087772A1,O=Cn1c2ccc(CCn3c4ccccc4c4ccccc43)cc2c2cc(CCn3c4ccccc4c4ccccc43)ccc21>>OCn1c2ccc(CCn3c4ccccc4c4ccccc43)cc2c2cc(CCn3c4ccccc4c4ccccc43)ccc21,,C1CCOC1,CO,[BH4-].[Na+],,val
US07097963B1,BrBr.Cc1cc(O)n2ncnc2n1>>Cc1nc2ncnn2c(O)c1Br,,CC(=O)O,,O,,val
US20020173517A1,Cc1c(C(F)F)ccc[n+]1[O-].O=[N+]([O-])O>>Cc1c(C(F)F)c([N+](=O)[O-])cc[n+]1[O-],,O=S(=O)(O)O,,O,,val
US20120208819A1,COC(=O)c1cc(C#N)ccc1-n1ccnc1>>COC(=O)c1cc(CN)ccc1-n1ccnc1,[Ni],CO,,N,,val
US20100010038A1,COC(=O)c1c(Br)ccc(N)c1C.O=C1CCC(=O)N1Cl>>COC(=O)c1c(C)c(N)cc(Cl)c1Br,,CC#N,CCOC(C)=O,,,val
US20140303186A1,CC(C)(C)OC(=O)n1nc(CBr)c2cccnc21.C[Si](C)(C)C#N>>CC(C)(C)OC(=O)n1nc(CC#N)c2cccnc21,,CC#N,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US03991012,CC(=O)O.CC12CCC(C(O)C1)C(C)(C)N2>>CC(=O)OC1CC2(C)CCC1C(C)(C)N2,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20120171245A1,N#CC1(C(=O)O)CC1.N[C@@H]1CCC[C@H](Nc2cc(-c3c[nH]c4ncc(F)cc34)ccc2F)C1>>N#CC1(C(=O)N[C@@H]2CCC[C@H](Nc3cc(-c4c[nH]c5ncc(F)cc45)ccc3F)C2)CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150167017A1,CC(=O)OC(C)=O.O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.c1ccncc1>>CC(=O)OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O,,c1ccncc1,,,,val
US20040248923A1,CCOC(=O)c1cnc2cc(OC)c(OCc3ccccc3)cc2c1Cl>>COc1cc2ncc(C(=O)O)c(Cl)c2cc1OCc1ccccc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20100048551A1,BrBr.NC(=O)c1cnc(Cl)c2c1[nH]c1ccccc12>>NC(=O)c1cnc(Cl)c2c1[nH]c1ccc(Br)cc12,[Zn],C1CCOC1,CC(=O)O,CCOC(C)=O,O=C([O-])O.[Na+],val
US20030013656A1,CCOC(=O)C(=O)CBr.O=c1[nH]c(S)nc2ccccc12>>CCOC(=O)C(=O)CSc1nc2ccccc2c(=O)[nH]1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,Cl,val
US20080070920A1,O=C(Cc1c(Cl)c(F)nc(F)c1Cl)OCc1ccccc1>>O=C(O)Cc1c(Cl)c(F)nc(F)c1Cl,[Pd],CCO,,,,val
US20050014807A1,CCCc1c(OCCCC(=O)N[C@@H](C)C(=O)O)ccc2c(C(F)(F)F)noc12.CI>>CCCc1c(OCCCC(=O)N(C)[C@@H](C)C(=O)O)ccc2c(C(F)(F)F)noc12,,C1CCOC1,,[H-].[Na+],,val
US20100130468A1,CCOC(=O)c1cc(Br)cc2c(CC3CCS(=O)(=O)C3)c[nH]c12>>O=C(O)c1cc(Br)cc2c(CC3CCS(=O)(=O)C3)c[nH]c12,,CO,,[Li+].[OH-],,val
US20100260709A1,COC(=O)[C@@H]1C[C@@]2(CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C1CCCCC1)C(C)(C)C)C(C)(C)C21CCC1>>COC(=O)[C@@H]1C[C@@]2(CN1C(=O)[C@@H](NC(=O)[C@@H](N)C1CCCCC1)C(C)(C)C)C(C)(C)C21CCC1,,C1COCCO1,,Cl,,val
US20060040968A1,CCOC(=O)c1cccc(-c2ccnc(NCCc3ccc(O)cc3)n2)c1>>O=C(O)c1cccc(-c2ccnc(NCCc3ccc(O)cc3)n2)c1,,CO,,[Na+].[OH-],,val
US20160185780A1,CC1(C)OB(C2=CCC(CC#N)(c3ccc(Cl)cc3)CC2)OC1(C)C.CN1CCC(N(C)C(=O)c2ccc(Nc3nc4c(Br)cccn4n3)cc2)CC1>>CN1CCC(N(C)C(=O)c2ccc(Nc3nc4c(C5=CCC(CC#N)(c6ccc(Cl)cc6)CC5)cccn4n3)cc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20020099092A1,CC(C)C[C@H](CNC(=O)c1ccccc1)CC(=O)O.OCc1ccccc1>>CC(C)C[C@H](CNC(=O)c1ccccc1)CC(=O)OCc1ccccc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130102599A1,CCOC(=O)c1nn(Cc2ccc(-n3cccn3)cc2)c2ccccc2c1=S.NN>>O=c1[nH]nc2c3ccccc3n(Cc3ccc(-n4cccn4)cc3)nc1-2,,CCO,,,,val
US04140775,Brc1cc(Br)cc(N2CCNCC2)c1.O=[N+]([O-])c1ccc(CCl)cc1>>O=[N+]([O-])c1ccc(CN2CCN(c3cc(Br)cc(Br)c3)CC2)cc1,,CCN(CC)CC,,Cl,Cl,val
US20150175562A1,CC(C)(C)c1cc(-c2cc(C(=O)O)ccc2CC2CCCCC2)cc(C(C)(C)C)c1.N>>CC(C)(C)c1cc(-c2cc(C(N)=O)ccc2CC2CCCCC2)cc(C(C)(C)C)c1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20070232645A1,CC(=O)Cl.Cc1ccc(Sc2cccc(N)c2)c([N+](=O)[O-])c1>>CC(=O)Nc1cccc(Sc2ccc(C)cc2[N+](=O)[O-])c1,,ClCCl,,,,val
US20060020003A1,COc1ccc(-c2ccc(CNCc3ccccc3)cc2)cc1Br.Cn1cc(C(=O)Cl)c2ccccc21>>COc1ccc(-c2ccc(CN(Cc3ccccc3)C(=O)c3cn(C)c4ccccc34)cc2)cc1Br,,ClCCl,,CCN(CC)CC,Cl,val
US20040058939A1,COc1ccnc2c1c(-c1ccnc(NC(C)=O)n1)c1ccnc(NS(=O)(=O)c3ccc(C)cc3)n12>>Cc1ccc(S(=O)(=O)Nc2nccc3c(-c4ccnc(N)n4)c4c(O)ccnc4n23)cc1,,Br,,O=C([O-])O.[Na+],,val
US20100081701A1,CC(C)CN(CC(=O)N1CCC[C@H]1C(N)=O)C(=O)OC(C)(C)C>>CC(C)CN(CC(=O)N1CCC[C@H]1C#N)C(=O)OC(C)(C)C,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20110017587A1,CC(C)(Br)C(=O)Br.[N-]=[N+]=NCCO>>CC(C)(Br)C(=O)OCCN=[N+]=[N-],CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20160075713A1,CCOC(=O)C(F)(F)c1ncc(C)cc1F>>Cc1cnc(C(F)(F)CO)c(F)c1,,CCO,,[BH4-].[Na+],,val
US20130203776A1,COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NOCCBr)c2n1.Cl>>O=C(NOCCCl)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)c[nH]c3=O)nc12,,CO,,,,val
US04468517,CN(C)CC1=NC(O)(CCl)CS1.O=S(Cl)Cl>>CN(C)Cc1nc(CCl)cs1.Cl,,ClCCCl,,,,val
US20160052939A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OC1CC2CCC1NC2>>CC(C)(C)OC(=O)N1CC2CCC1C(O)C2,[Pd],CCO,,,,val
US20020128269A1,COc1ccc(S(=O)(=O)N2CCNCC2C(=O)NN2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1OC.O=C(Cl)OCc1ccccc1>>COc1ccc(S(=O)(=O)N2CCN(C(=O)OCc3ccccc3)CC2C(=O)NN2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1OC,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20050227987A1,CCCc1ccc(C(=O)Cl)cc1.Nc1ccc(C(=O)c2ccccc2)cc1>>CCCc1ccc(C(=O)Nc2ccc(C(=O)c3ccccc3)cc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20110306607A1,Cc1ccc2c(c1)OC1(CCNCC1)c1ccc(C#N)n1-2.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1ccc2c(c1)OC1(CCN(C(=O)C(F)(F)F)CC1)c1ccc(C#N)n1-2,,ClCCl,,CCN(CC)CC,,val
US03979513,COc1cccc(C(O)c2ccccc2)c1.O=C=O>>COc1cccc2c1C(=O)OC2c1ccccc1,,CCCCCC,CCOCC,[Li]CCCC,,val
US05294734,CCOC(=O)C(C=C(CP(=O)(OC(C)C)OC(C)C)C1CCN(C(C)=O)CC1)NC=O>>NC(C=C(CP(=O)(O)O)C1CCNCC1)C(=O)O,,Cl,,,,val
US20080312226A1,CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccccc3F)cs2)CC1>>Fc1ccccc1-c1csc(N2CCNCC2)n1,,CCOC(C)=O,,Cl,,val
US20150225405A1,CCOC(=O)c1cc(Br)n(C)n1>>Cn1nc(C(=O)O)cc1Br,,C1CCOC1,O,[Li+].[OH-],,val
US20130158075A1,C1N2CN3CN1CN(C2)C3.Cl.O=C(CBr)c1ccc([N+](=O)[O-])cc1>>Cl.NCC(=O)c1ccc([N+](=O)[O-])cc1,,CCO,ClCCl,,,val
US20120208839A1,Nc1nc(OCC(F)F)c(C(=O)N[C@@H]2CC[C@@H](C(F)(F)F)CC2)cc1[N+](=O)[O-]>>Nc1cc(C(=O)N[C@@H]2CC[C@@H](C(F)(F)F)CC2)c(OCC(F)F)nc1N,[Ni],C1CCOC1,,,,val
US04816178,CCCCCCCc1ccc(-c2ccccc2)c(C(=O)O)c1.ClP(Cl)(Cl)(Cl)Cl>>CCCCCCCc1ccc(-c2ccccc2)c(C(=O)Cl)c1,,c1ccccc1,,,,val
US20130030012A1,Fc1ccc(Br)cn1.Oc1ccc(F)c(F)c1>>Fc1ccc(Oc2ccc(Br)cn2)cc1F,,CCOC(C)=O,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US20050090472A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.COc1cccc(NC(=O)c2ccc(OCC(C)C)c(C#N)c2)c1>>COc1cccc(NC(=S)c2ccc(OCC(C)C)c(C#N)c2)c1,,Cc1ccccc1,,,,val
US20120238559A1,Brc1c[nH]c2cnccc12.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>O=[N+]([O-])c1ccc(S(=O)(=O)n2cc(Br)c3ccncc32)cc1,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US05955548,CC(C)CCNC(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)=C(C#N)C(=O)OC(C)(C)C>>CC(C)CCNC(=CC#N)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,ClCCl,,,,val
US06339045B1,CN(Cc1ccccc1)c1cc(Br)nc(Oc2cccc(C(F)(F)F)c2)c1.O=C=O>>CN(Cc1ccccc1)c1cc(Oc2cccc(C(F)(F)F)c2)nc(C(=O)O)c1,,CCOCC,,CCCCCC,[Li]CCCC,val
US20110190255A1,CCCc1c(-c2nc(-c3ccc(C(O)CBr)cc3)no2)noc1-c1ccccc1.O=C(O)C1CCCNC1>>CCCc1c(-c2nc(-c3ccc(C(O)CN4CCCC(C(=O)O)C4)cc3)no2)noc1-c1ccccc1,,CS(C)=O,,C1CCC2=NCCCN2CC1,,val
US07910740B2,CC(=O)C(Cl)Cc1ccc(Cl)c(Cl)c1.COc1cc(NC(N)=S)ccc1-n1cnc(C)c1>>COc1cc(Nc2nc(C)c(Cc3ccc(Cl)c(Cl)c3)s2)ccc1-n1cnc(C)c1,,CCO,,,,val
US06265575B1,CC(C)(C)[Si](C)(C)Cl.OCc1cc(Br)ccc1OCCN1CCCC1>>CC(C)(C)[Si](C)(C)OCc1cc(Br)ccc1OCCN1CCCC1,,CN(C)C=O,,O,c1c[nH]cn1,val
US20100113444A1,CCOC(=O)c1c(O)n(-c2ccccc2[N+](=O)[O-])c(=O)n(Cc2ccccc2)c1=O.NCC(=O)O>>O=C(O)CNC(=O)c1c(O)n(-c2ccccc2[N+](=O)[O-])c(=O)n(Cc2ccccc2)c1=O,,CCO,,C1CCC2=NCCCN2CC1,Cl,val
US20060135578A1,COc1cc(C=O)ccc1O.ClCc1coc(-c2ccco2)n1>>COc1cc(C=O)ccc1OCc1coc(-c2ccco2)n1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04485106,NNc1nnc(Cl)c2c1CCCC2.O=N[O-]>>Clc1nn2nnnc2c2c1CCCC2,,O,,CC(=O)O,,val
US04579584,COc1nc(N)nc(NC(C)(C)C)n1.O=C=NS(=O)(=O)c1ccccc1OC(F)F>>COc1nc(NC(=O)NS(=O)(=O)c2ccccc2OC(F)F)nc(NC(C)(C)C)n1,,C1COCCO1,,,,val
US20100010035A1,CCOCc1cc(CO)ccc1-c1cc(C)sc1S(=O)(=O)N(COCCOC)c1onc(C)c1C.CS(=O)(=O)Cl>>CCOCc1cc(COS(C)(=O)=O)ccc1-c1cc(C)sc1S(=O)(=O)N(COCCOC)c1onc(C)c1C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140038999A1,CNC(=O)c1c(-c2ccc(Cl)cc2F)ccnc1C>>Cc1nccc2c1c(=O)n(C)c1cc(Cl)ccc21,,C1CCOC1,,[H-].[Na+],,val
US20020193596A1,COC(=O)[C@H](CCSC)NC(=O)c1ccc(CNc2cccnc2)cc1-c1ccccc1.Cl>>COC(=O)[C@H](CCSC)NC(=O)c1ccc(CNc2cccnc2)cc1-c1ccccc1.Cl,,CCOC(C)=O,,,,val
US20050239656A1,CCCC(=O)Cl.CNC(c1cnccc1C(F)(F)F)C(C)C>>CCCC(=O)N(C)C(c1cnccc1C(F)(F)F)C(C)C,,CCN(CC)CC,,C1CCOC1,,val
US20140275528A1,CCC(CO)NC(=O)C(C)(C)Br.Cn1c(=O)c2c(nc(S)n2Cc2cccc(Br)c2)n(C)c1=O>>CCC(CO)NC(=O)C(C)(C)Sc1nc2c(c(=O)n(C)c(=O)n2C)n1Cc1cccc(Br)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04165373,CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1.Sc1ccc2nnnn2n1>>NC1C(=O)N2C(C(=O)O)=C(CSc3ccc4nnnn4n3)CS[C@H]12,,CC(C)=O,O,Cl,O=C([O-])O.[Na+],val
US20100173889A1,COC(=O)C1(N)CCC1.COc1cc(C)c(S(=O)(=O)Cl)c(C)c1>>COC(=O)C1(NS(=O)(=O)c2c(C)cc(OC)cc2C)CCC1,,ClCCl,ClCCl,CCN(CC)CC,,val
US03966953,CCN1C(=O)CSC1=NO.CN(SC(Cl)(Cl)Cl)C(=O)F>>CCN1C(=O)CSC1=NOC(=O)N(C)SC(Cl)(Cl)Cl,,C1COCCO1,O,CCN(CC)CC,,val
US04735959,CCCC(c1ccccc1N1CCCCC1)C(C(N)=O)c1ccc(C=CC(=O)OCC)cc1>>CCCC(c1ccccc1N1CCCCC1)C(C(N)=O)c1ccc(CCC(=O)OCC)cc1,[Pd],CCO,,[H][H],,val
US20130336921A1,Nc1ccc(N2CCCCC2)cc1C(=O)Nc1ccn(-c2cccc(C(F)(F)F)c2)n1.O=C(O)c1cccc(CCl)n1>>O=C(Nc1ccc(N2CCCCC2)cc1C(=O)Nc1ccn(-c2cccc(C(F)(F)F)c2)n1)c1cccc(CCl)n1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US05087631,CC(C)N(C(O)=NCC[Si](C)(C)C)C(C)C.COc1ccc(C(O)C(=O)O)cc1>>COc1ccc(C(O)C(=O)OCC[Si](C)(C)C)cc1,,C1COCCO1,CCOC(C)=O,,,val
US20140206706A1,CCOC(=O)C(Cc1cccc(OC(F)F)c1)N=C(c1ccccc1)c1ccccc1>>CCOC(=O)C(N)Cc1cccc(OC(F)F)c1,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US05914402,Cc1cc(O)ccc1N.Cc1cccc2c1=NC(=O)C1CCOC=21>>Cc1cc(O)ccc1N1CCc2c1c1cccc(C)c1[nH]c2=O,,OCCOCCO,,O,,val
US20160024072A1,COc1cn(Cc2ccc(Cl)cc2)c(Cl)nc1=O>>O=c1nc(Cl)n(Cc2ccc(Cl)cc2)cc1O,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20150119402A1,NCc1ccc(F)cc1.O=C(c1nccnc1Cl)c1c[nH]c2cc(Cl)ccc12>>O=C(c1nccnc1NCc1ccc(F)cc1)c1c[nH]c2cc(Cl)ccc12,,CS(C)=O,,CO,ClCCl,val
US04349472,CN1CCc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1.O=C(Cl)c1ccccc1>>CN1CCc2cc(Cl)c(OC(=O)c3ccccc3)cc2[C@H](c2ccccc2)C1.Cl,,CC#N,,O=C([O-])O.[Na+],,val
US20150259295A1,COC(=O)c1c(Br)cnn1C.OB(O)c1ccccc1>>COC(=O)c1c(-c2ccccc2)cnn1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100267767A1,O=c1c2c(O)cc(O)cc2c(Br)cn1-c1ccc(O)cc1.OB(O)c1ccccc1>>O=c1c2c(O)cc(O)cc2c(-c2ccccc2)cn1-c1ccc(O)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20100041642A1,Cc1ccc(N)cc1B1OC(C)(C)C(C)(C)O1.Cc1nnc(-c2ccc(Br)cn2)o1>>Cc1nnc(-c2ccc(-c3cc(N)ccc3C)cn2)o1,,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20120183563A1,COC(=O)c1cnc(O)cn1.O=C([O-])C(F)(F)Cl>>COC(=O)c1cnc(OC(F)F)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160083370A1,COc1cc(C)nc(N2CCNCC2)n1.Cc1ccc(S(=O)(=O)OCCCCc2c[nH]c3ccc(C#N)cc23)cc1>>COc1cc(C)nc(N2CCN(CCCCc3c[nH]c4ccc(C#N)cc34)CC2)n1,,CC#N,,[I-].[K+],,val
US20040157886A1,CS(=O)(=O)Nc1ccc(NCC(=O)O)cc1.c1ccc(OC2CCNCC2)cc1>>CS(=O)(=O)Nc1ccc(NCC(=O)N2CCC(Oc3ccccc3)CC2)cc1,,CCOCC,,Cl,,val
US20150166543A1,COc1cc(C(=O)O)cc([N+](=O)[O-])c1>>COc1cc(CO)cc([N+](=O)[O-])c1,,C1CCOC1,,B,,val
US06169107A,CCOC(=O)c1cc2c(Cl)ccc(OCc3ccccc3)c2[nH]1.CI>>CCOC(=O)c1cc2c(Cl)ccc(OCc3ccccc3)c2n1C,,CN(C)C=O,,[H-].[Na+],,val
US20100280071A1,Cc1ccc([N+](=O)[O-])c(NC2CCN([C@@H]3CC[C@H](OCC4CC4)CC3)CC2)c1>>Cc1ccc(N)c(NC2CCN([C@@H]3CC[C@H](OCC4CC4)CC3)CC2)c1,[Ni],CCO,,NN,O,val
US20090076206A1,CCCCCCCCCCCCN.O=C1c2ccccc2C(=O)c2cc(S(=O)(=O)Cl)ccc21>>CCCCCCCCCCCCNS(=O)(=O)c1ccc2c(c1)C(=O)c1ccccc1C2=O,,C1CCOC1,,,,val
US20080269210A1,CS(=O)(=O)N1CCNCC1.O=C(O)c1cc2nc(Cl)nc(N3CCOCC3)c2s1>>CS(=O)(=O)N1CCN(C(=O)c2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20130274244A1,Cc1cccc(Cn2nc(C)c3c(NC(=O)c4cnc5cc(OCCN6CCN(C(=O)OC(C)(C)C)CC6)ccn45)cccc32)n1>>Cc1cccc(Cn2nc(C)c3c(NC(=O)c4cnc5cc(OCCN6CCNCC6)ccn45)cccc32)n1,,CO,,Cl,,val
US20150191483A1,C=Cc1cc(S(=O)(=O)C2(c3ccc(C(OCc4c(F)cccc4F)(C(F)(F)F)C(F)(F)F)cc3)CCN(Cc3ccccc3)C2)ccc1F>>CCc1cc(S(=O)(=O)C2(c3ccc(C(OCc4c(F)cccc4F)(C(F)(F)F)C(F)(F)F)cc3)CCNC2)ccc1F,[Pd],CO,,,,val
US03933804,CC(=CCCl)CCOC(C)C.OCc1ccc2c(c1)OCO2>>CC(=CCOCc1ccc2c(c1)OCO2)CCOC(C)C,,c1ccccc1,,O,[Na+].[OH-],val
US20080275181A1,Cc1ccccc1.O=C1OC(=O)c2cc(Oc3ccc4c(c3)C(=O)OC4=O)ccc21.c1ccncc1>>CC1CCC(=O)O1.CCOC(=O)c1ccccc1,,Cc1ccccc1,,,,val
US20150329535A1,CC(C)(C)OC(=O)NCCc1ccc(OCCCCc2ccc(-c3ccccc3)c(NC(=O)O[C@H]3CN4CCC3CC4)c2)cc1>>NCCc1ccc(OCCCCc2ccc(-c3ccccc3)c(NC(=O)O[C@H]3CN4CCC3CC4)c2)cc1,,C1COCCO1,Cl,,,val
US20040167121A1,NC(=O)c1cc(N2CCCCC2)ccc1N.O=C(Cl)Cl>>O=c1[nH]c(=O)c2cc(N3CCCCC3)ccc2[nH]1,,C1COCCO1,,,,val
US03996209,C1N2CN3CN1CN(C2)C3.O=C(CCl)Nc1ccc(Cl)cc1C(=O)c1ccccc1>>O=C1CN=C(c2ccccc2)c2cc(Cl)ccc2N1,,CCO,,,,val
US20050261350A1,CC(C)(C)ON.CC1(C)C(=O)N(CCC=O)c2cc3[nH]c(NC(=O)c4ccccc4)nc3cc21>>CC(C)(C)ON=CCCN1C(=O)C(C)(C)c2cc3nc(NC(=O)c4ccccc4)[nH]c3cc21,,CO,O,Cl,,val
US20090324551A1,Clc1nc(Cl)c2nc[nH]c2n1.N#Cc1ccc(CBr)cc1>>N#Cc1ccc(Cn2cnc3c(Cl)nc(Cl)nc32)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100063107A1,CCOC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Oc2ccccc2)c1.CNC(=O)c1cc(Oc2ccc(N)c(F)c2)ccn1>>CCOC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(C(=O)NC)c3)cc2F)c1,,C1CCOC1,,CCN(CC)CC,,val
US08507683B2,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc([N+](=O)[O-])c(O)cc12.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc([N+](=O)[O-])c(OS(=O)(=O)C(F)(F)F)cc12,CN(C)c1ccncc1,O,c1ccncc1,,,val
US20120238541A1,CI.O=c1c(I)c(-c2ccccc2)oc2c(=O)[nH]ccc12>>Cn1ccc2c(=O)c(I)c(-c3ccccc3)oc2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090221669A1,Nc1ccccc1N.O=C(O)c1ccc(N(Cc2ccccc2)Cc2ccccc2)cc1>>Nc1ccccc1NC(=O)c1ccc(N(Cc2ccccc2)Cc2ccccc2)cc1,,CCOC(C)=O,CN(C)C=O,ClCCCl,On1nnc2ccccc21,val
US20070299113A1,COc1ccc(OC)c(-c2csc3nc(C45CC6CC(CC(C6)C4)C5)cn23)c1.Cl>>Cl.Oc1ccc(O)c(-c2csc3nc(C45CC6CC(CC(C6)C4)C5)cn23)c1,,ClCCl,,BrB(Br)Br,,val
US20090143353A1,CN(C)C[C@@H]1CCCN1C(=O)OC(C)(C)C.Cc1c(-c2ccccc2)c(F)c2oc(C3CC3)nc2c1C#N>>Cc1c(-c2ccccc2)c(N2CCC[C@H]2CN(C)C)c2oc(C3CC3)nc2c1C#N,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20060069132A1,CC(C)(C)C(=O)CBr.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)C(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20120289501A1,O=C1CC(c2ccco2)Oc2cc(Br)ccc21>>OC1CC(c2ccco2)Oc2cc(Br)ccc21,,C1CCOC1,,,,val
US20150011528A1,CCOC(=O)C(C)Br.O=C(Nc1nc2ccccc2s1)c1cc(F)cc(F)c1>>CCOC(=O)C(C)n1c(=NC(=O)c2cc(F)cc(F)c2)sc2ccccc21,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20110224188A1,CC(C)(C)C=O.C[C@@H](N)C(=O)Nc1cc(Cl)c(F)c(Cl)c1>>C[C@H]1N[C@H](C(C)(C)C)N(c2cc(Cl)c(F)c(Cl)c2)C1=O,,CCCCCC,Cc1ccccc1,,,val
US20140179902A1,CC(C)(C)OC(=O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)ON1C(=O)CCC1=O)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.CC(C)(C)OC(=O)CN(CCCC[C@H](N)C(=O)O)Cc1ccccn1>>CC(C)(C)OC(=O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)N[C@@H](CCCCN(CC(=O)OC(C)(C)C)Cc1ccccn1)C(=O)O)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04540697,CC(=O)c1cc(Cl)ccc1O.O=Cc1ccccc1>>O=C(C=Cc1ccccc1)c1cc(Cl)ccc1O,,O,,O=S(=O)(O)O,[Na+].[OH-],val
US20150087663A1,CC(C)C(=N)NO.O=C(Cl)c1c(Cl)ncnc1Cl>>CC(C)C(N)=NOC(=O)c1c(Cl)ncnc1Cl,,ClCCl,O,CCN(C(C)C)C(C)C,CO,val
US20160096839A1,C[C@@H]1C=CC[C@H](NC(=O)OC(C)(C)C)c2cc(F)cc(c2)-c2c(cnn2C)NC1=O>>C[C@@H]1CCC[C@H](N)c2cc(F)cc(c2)-c2c(cnn2C)NC1=O,O=[Pt]=O,CCO,,,,val
US20150038437A1,CCc1cc(C(=O)OC)c(OC)nc1-c1cc2cc(CO)n(C)c2s1>>CCc1cc(C(=O)OC)c(OC)nc1-c1cc2cc(C=O)n(C)c2s1,O=[Mn]=O,ClCCl,,,,val
US20090156590A1,CC(C(=O)O)c1ccc(N)cc1.O=[N+]([O-])O>>CC(C(=O)O)c1ccc(N)c([N+](=O)[O-])c1,,CC(=O)O,,O,,val
US04584293,CNC1CCc2cc(OC)ccc2C1.COc1cc2c(cc1OC)CC(=O)N(CCCCl)CC2>>COc1ccc2c(c1)CCC(N(C)CCCN1CCc3cc(OC)c(OC)cc3CC1=O)C2,,CCN(CC)CC,,,,val
US04226885,N=C(N)NN.O=CCOc1ccccc1Cl.O=S(=O)(O)O>>N=C(N)NN=CCOc1ccccc1Cl.O=S(=O)([O-])[O-],CC(=O)O,CCO,,O,,val
US20100190745A1,CCOC(=O)/C=C\N(C)C.O=C(O)c1cc(I)ccc1F>>CCOC(=O)/C(=C\N(C)C)C(=O)c1cc(I)ccc1F,,Cc1ccccc1,O,CCN(CC)CC,O=S(Cl)Cl,val
US20100280068A1,CSC(Oc1ccc2ncc(C#C[Si](C)(C)C)cc2c1)C(=O)NC(C)(C)C>>C#Cc1cnc2ccc(OC(SC)C(=O)NC(C)(C)C)cc2c1,,CCOC(C)=O,CO,O=C([O-])[O-].[K+].[K+],,val
US20140350011A1,CN(C)c1cccc(C=O)c1.NC(=O)[C@H]1[C@@H]2C=C[C@@H](C2)[C@H]1Nc1ccnc(N)c1N>>CN(C)c1cccc(-c2nc3c(N[C@@H]4[C@H]5C=C[C@H](C5)[C@@H]4C(N)=O)ccnc3[nH]2)c1,,CCO,,C,O=C[O-].[NH4+],val
US05350736,CC(=O)N=c1sc(C)cn1-c1ccc(F)c(C(F)(F)F)c1.Cl>>Cc1cn(-c2ccc(F)c(C(F)(F)F)c2)c(=N)s1.Cl,,CCO,O,,,val
US05656626,COc1c(-c2ccsc2)c(=O)c2ccc(Cl)cc2[nH]c1=O>>O=c1[nH]c2cc(Cl)ccc2c(=O)c(-c2ccsc2)c1O,,C1CCOC1,Cl,,,val
US20040116422A1,CC(=O)c1cccc(N)c1.COc1cc2ncnc(Cl)c2cc1OC(C)=O>>COc1cc2ncnc(Nc3cccc(C(C)=O)c3)c2cc1OC(C)=O.Cl,,CC(C)O,,,,val
US20100160369A1,N#Cc1ccc(-c2noc(-c3cn4cc(C(F)(F)F)cc(Cl)c4n3)n2)c(Cl)c1.NO>>NC(=NO)c1ccc(-c2noc(-c3cn4cc(C(F)(F)F)cc(Cl)c4n3)n2)c(Cl)c1,,CCO,,CCN(CC)CC,Cl,val
US20160222012A1,Clc1ncnc2nc[nH]c12.Fc1ccc2cc(C3CCCN3)c(-c3cccnc3)nc2c1>>Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(-c3cccnc3)nc2c1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20080090834A1,Cc1ccc(-n2cc(-c3ccccn3)nc2-c2ccc(Nc3ncccc3[N+](=O)[O-])cc2)cn1>>Cc1ccc(-n2cc(-c3ccccn3)nc2-c2ccc(Nc3ncccc3N)cc2)cn1,[Pd],CO,,[H][H],,val
US20160222028A1,CCN(C(C)C)C(C)C.COC(=O)c1ccc2c(c1)OC[C@H](C)NC2.O=C(O)C1(CO)COC1>>COC(=O)c1ccc2c(c1)OC[C@H](C)N(C(=O)C1(CO)CCC1)C2,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US05504107,CO.COC=CC[C@H]1OC(C)(C)OC1=O>>COC(=O)[C@H]1CCC(OC)O1,,CO,,,,val
US20140213571A1,OCc1c(-c2cc(Br)ccc2O)nc2ccccn12>>Brc1ccc2c(c1)-c1nc3ccccn3c1CO2,,Cc1cc(C)cc(C)c1,,O,,val
US20030083357A1,CC(C)I.Cc1ccc2c(c1)NCCC2>>Cc1ccc2c(c1)N(C(C)C)CCC2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080262042A1,COC(=O)c1ccc(S(=O)(=O)n2cc(CN(C)C(=O)OC(C)(C)C)c(F)c2-c2cccnc2F)o1>>CN(Cc1cn(S(=O)(=O)c2ccc(CO)o2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C,,C1CCOC1,Cc1ccccc1,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US05300509,COc1ccc(CCN)cc1.CSc1nc(N)c(N=O)c(N)n1>>COc1ccc(CCNc2nc(N)c(N=O)c(N)n2)cc1,,O,,,,val
US20080312226A1,CC(=O)N(C)c1ccc(N)cc1.O=C(Cl)OCC(Cl)(Cl)Cl>>CC(=O)N(C)c1ccc(NC(=O)OCC(Cl)(Cl)Cl)cc1,,C1CCOC1,,c1ccncc1,,val
US20100249346A1,CC1=Cc2ccccc2C1.Cc1cc2c(s1)C(CCOS(=O)(=O)C(F)(F)F)c1sc(C)cc1-2>>CC1=Cc2ccccc2C1CCC1=C2SC(C)C=C2c2cc(C)sc21,,C1CCOC1,,[Li]CCCC,,val
US20140303143A1,CC(=O)c1cccc2ccncc12>>CC(O)c1cccc2ccncc12,,CCO,,[BH4-].[Na+],,val
US20070083052A1,C[C@@H](Br)C(=O)Cl.N[C@@H](Cc1ccccc1Br)C(=O)O>>C[C@@H](Br)C(=O)N[C@@H](Cc1ccccc1Br)C(=O)O,,Cc1ccccc1,O,Cl,[Na+].[OH-],val
US20150191465A1,CCc1nc(S(C)(=O)=O)nc(N[C@@H](C)c2nc3ccn(C)c3cc2N2CCN(C(=O)OC(C)(C)C)CC2)c1C#N.N>>CCc1nc(N)nc(N[C@@H](C)c2nc3ccn(C)c3cc2N2CCN(C(=O)OC(C)(C)C)CC2)c1C#N,,C1COCCO1,CCOC(C)=O,,,val
US20040236084A1,CSc1nc(Nc2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cn2)nc(NC2CCCC2)n1.Cl>>CSc1nc(Nc2ccc(N3CCNCC3)cn2)nc(NC2CCCC2)n1.Cl,,CO,,CCOCC,,val
US20110144146A1,CCC=O.c1ccc2c3c([nH]c2c1)CNCC3>>CCCN1CCc2c([nH]c3ccccc23)C1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150025095A1,CCOC(=O)C(C)C(C)=O.NC(N)=S>>Cc1[nH]c(=S)[nH]c(=O)c1C,,C1CCOC1,CCO,CC(C)(C)[O-].[K+],,val
US20040123401A1,O=[N+]([O-])c1ccc(N2CCC(n3cc[n+](CCCn4cc[n+](C5CCN(c6ccc([N+](=O)[O-])cc6)C5)c4)c3)C2)cc1.[Br-].[Br-]>>Nc1ccc(N2CCC(n3cc[n+](CCCn4cc[n+](C5CCN(c6ccc(N)cc6)C5)c4)c3)C2)cc1.[Br-].[Br-],[Pd],CCO,O,,,val
US20050234046A1,COC(=O)COCc1cccc(S(=O)(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1>>O=C(O)COCc1cccc(S(=O)(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1,,C1CCOC1,CO,[Li+].[OH-],,val
US20120309746A1,COc1ccc(Nc2cc(-c3cccc(C(=O)Nc4ccc(C(=O)OC(C)(C)C)cc4)c3)cn3ncnc23)nc1OC.O=C(O)C(F)(F)F>>COc1ccc(Nc2cc(-c3cccc(C(=O)Nc4ccc(C(=O)O)cc4)c3)cn3ncnc23)nc1OC.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20090042852A1,CCc1cnc(-c2cnc(N3CCC(C(=O)OC)CC3)c(Cl)c2S(C)(=O)=O)o1.CN>>CCc1cnc(-c2cnc(N3CCC(C(=O)OC)CC3)c(Cl)c2NC)o1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20070244118A1,O=C(OCc1ccccc1)N1CCC(N2CCCCCC2=O)CC1>>O=C1CCCCCN1C1CCNCC1,[Pd],CCO,,,,val
US05270334,C[Si](C)(C)CCOCn1ccnc1C=O>>C[Si](C)(C)CCOCn1ccnc1CO,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150361100A1,CC(c1cc2ccccn2c1-c1ccccn1)n1nc(I)c2c(N)ncnc21.OB(O)c1cc(O)cc(F)c1>>CC(c1cc2ccccn2c1-c1ccccn1)n1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US05393732,CC(=O)OC(C)=O.CCC(C)(CC)C(O)c1ncn(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1.O=[PH](O)O>>CCC(C)(CC)C(OC(C)=O)c1ncn(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1.O=[PH](O)O,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20140018326A1,COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)NS(=O)(=O)c1ccc2ncsc2c1)C(c1ccccc1)c1ccccc1.OCc1cnoc1>>COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)N(Cc1cnoc1)S(=O)(=O)c1ccc2ncsc2c1)C(c1ccccc1)c1ccccc1,,CC(C)CCO,,,,val
US20080139595A1,C=Cc1cn(S(=O)(=O)c2ccc(C)cc2)c2nccc(Oc3ccc(NC(C)=O)cc3F)c12>>CCc1cn(S(=O)(=O)c2ccc(C)cc2)c2nccc(Oc3ccc(NC(C)=O)cc3F)c12,[Pd],CCO,,,,val
US20120015994A1,COC(=O)C(NC(=O)C(COc1ccc(Br)cc1)NC(=O)OC(C)(C)C)C(C)C.OB(O)c1ccccc1>>COC(=O)C(NC(=O)C(COC1=CCC(c2ccccc2)C=C1)NC(=O)OC(C)(C)C)C(C)C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20090118236A1,COCOc1ccc(Br)cc1N(C)C.Cc1cc(O[Si](C(C)C)(C(C)C)C(C)C)cc(C)c1C=O>>COCOc1ccc(C(O)c2c(C)cc(O[Si](C(C)C)(C(C)C)C(C)C)cc2C)cc1N(C)C,,C1CCOC1,,[Li]CCCC,,val
US05063225,C=C(C(=O)O)c1ccc(OC)cc1.Nc1ccccc1S>>COc1ccc(C(CSc2ccccc2N)C(=O)O)cc1,,CCO,,,,val
US20050197342A1,COc1ccc2cc(C)c(Cl)nc2c1>>COc1ccc2cc(C)cnc2c1,[Pd],CO,,CCN(CC)CC,[H][H],val
US06127386,CC(C)(C)OC(=O)N1CC[C@H]1COc1cnc(Cl)c(Br)c1.OB(O)c1ccc(Cl)cc1>>Clc1ccc(-c2cc(OC[C@@H]3CCN3)cnc2Cl)cc1,,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US04608438,CCCCC(Br)C(C)=O.c1c[nH]cn1>>CCCCC(C(C)=O)n1ccnc1,,CN(C)C=O,,O,,val
US20160046638A1,COCC1Cc2cc(C)cc(N)c2O1.O=C1CCC(=O)N1Br>>COCC1Cc2c(Br)c(C)cc(N)c2O1,,CN(C)C=O,,,,val
US04358593,C1CCNCC1.CS(=O)(=O)Oc1ccc(-c2sc3cc(OS(C)(=O)=O)ccc3c2C(=O)c2ccc(OCCCl)cc2)cc1>>CS(=O)(=O)Oc1ccc(-c2sc3cc(OS(C)(=O)=O)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1.Cl,,CN(C)C=O,,[I-].[K+],,val
US08629147B2,COc1ncccc1-c1ccc(O)c(C=O)c1.Nc1ccc(C(=O)O)cc1N>>COc1ncccc1-c1ccc(O)c(-c2nc3ccc(C(=O)O)cc3[nH]2)c1,,CC(=O)N(C)C,,CCOC(C)=O,,val
US20010047105A1,CON(C)C(=O)Cc1cccc(C(F)(F)F)c1.COP(C)(=O)OC>>COP(=O)(CC(=O)Cc1cccc(C(F)(F)F)c1)OC,,Cc1ccccc1,O,CC(=O)O,[Li]CCCC,val
US20100210641A1,CCOC(=O)c1cccc(-c2ccn3c(-c4cccc(-n5cccn5)c4)cnc3c2)c1.NCCO>>O=C(NCCO)c1cccc(-c2ccn3c(-c4cccc(-n5cccn5)c4)cnc3c2)c1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US05225558,C/C(N)=C/C#N.CC(C)OC(=O)CC(=N)N.O=Cc1cccc2ncc(-c3ccccc3)cc12>>CC1=C(C#N)C(c2cccc3ncc(-c4ccccc4)cc23)C(C(=O)OC(C)C)=C(N)N1,,CC(C)O,,Cl,CC(=O)[O-].[Na+],val
US20150126490A1,CC(=O)OC(C)=O.CC(C)(C)[S@](=O)N[C@H](CN)c1cc(F)cc(Br)c1>>CC(=O)NC[C@@H](N)c1cc(F)cc(Br)c1,,ClCCl,,Cl,c1ccncc1,val
US20150018547A1,CON.O=C1COc2cc(OCc3ccc(Cl)cc3Cl)ccc21>>CON=C1COc2cc(OCc3ccc(Cl)cc3Cl)ccc21,,CO,,Cl,CC(=O)[O-].[Na+],val
US20110065702A1,C[Si](C)(C)CCOCn1nc(/C=C/c2ccncc2)c2ccc(C=O)cc21.O=C1Cc2ccccc2N1>>C[Si](C)(C)CCOCn1nc(/C=C/c2ccncc2)c2ccc(/C=C3/C(=O)Nc4ccccc43)cc21,,CO,,C1CCNCC1,,val
US20140088124A1,COC(=O)C[C@@H]1CC[C@@H](OC2CCN(C(=O)OCc3ccccc3)CC2)CC1>>COC(=O)C[C@@H]1CC[C@@H](OC2CCNCC2)CC1,[Pd],CO,,,,val
US20060276536A1,CN.Cc1ccccc1C=CC(=O)C=Cc1ccccc1C>>Cc1ccccc1C1CC(=O)CC(c2ccccc2C)N1C,,CN(C)C=O,,O,,val
US04436748,CCCCc1cc2cc(OC)c(Cl)c(Cl)c2s1>>CCCCc1cc2cc(O)c(Cl)c(Cl)c2s1,,O,,Cl,c1ccncc1,val
US20160221990A1,CC(C)(C)[Si](C)(C)Oc1cc(Br)cc(CBr)c1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1cc(Br)cc(Cn2ccnc2)c1,,CN(C)C=O,,,,val
US20100004239A1,Cc1c(C=O)[nH]c2c1C(=O)N(CCN(C)C)CC2.O=C1Cc2cc(F)ccc2N1>>Cc1c(C=C2C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN(C)C)CC2,,CCO,,C1CCNCC1,,val
US20110105436A1,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.Cc1cccc(Nc2nc(-c3ccncc3)c(C=O)s2)c1>>COC(=O)/C=C/c1sc(Nc2cccc(C)c2)nc1-c1ccncc1,,ClCCl,,,,val
US05332734,Cc1cccc(NC(=O)[C@@H](NC(=O)CNC(=O)C2c3ccccc3-c3ccccc32)C(C)C)c1C(=O)O>>Cc1cccc2nc([C@@H](NC(=O)CNC(=O)C3c4ccccc4-c4ccccc43)C(C)C)oc(=O)c12,,CN(C)C=O,,O,,val
US04021434,CCOCCOC(=O)C1=C(C)NC(C)=C(C(=O)OCCOCC)C1c1cccc([N+](=O)[O-])c1.CCOCCl>>CCOCCOC(=O)C1=C(C)N(COCC)C(C)=C(C(=O)OCCOCC)C1c1cccc([N+](=O)[O-])c1,,CC(=O)O,O,C1CCOC1,[H-].[Na+],val
US04431564,Brc1ccc(-c2ccccc2)cc1.COCCOS(=O)(=O)c1ccc(C)cc1>>COCCc1ccc(-c2ccccc2)cc1,,CCOCC,O,Cl,[Mg],val
US20080009530A1,CCOC(=O)CP(=O)(OCC)OCC.O=Cc1cc(C2CC2)nn1Cc1ccc(C(F)(F)F)cc1Cl>>CCOC(=O)/C=C/c1cc(C2CC2)nn1Cc1ccc(C(F)(F)F)cc1Cl,,C1CCOC1,CN(C)C=O,[H-].[Na+],[Cl-].[NH4+],val
US20150355456A1,CCCCC(CC)CBr.O=[N+]([O-])c1cccc(O)c1>>CCCCC(CC)COc1cccc([N+](=O)[O-])c1,,O,,[K+].[OH-],,val
US20030186077A1,COc1ccc2c(c1)-c1c([nH]c3c1-c1cc(OC)ccc1CC3)CC2>>COc1ccc2ccc3[nH]c4ccc5ccc(OC)cc5c4c3c2c1,[Pd],,,,,val
US20100029753A1,COc1cc(C(C)(C)C)ccc1S(=O)(=O)O.ClP(Cl)(Cl)(Cl)Cl>>COc1cc(C(C)(C)C)ccc1S(=O)(=O)Cl,,CC(Cl)Cl,,,,val
US20040242593A1,CCCCC1(c2cc(OC)cc(OC)c2)SCCS1.COc1cc(OC)cc(C(=O)C2CCCCCC2)c1>>COc1cc(OC)cc(C2(C3CCCCCC3)SCCS2)c1,,CCCCCC,CCOC(C)=O,,,val
US20120184542A1,CC(C)(C)OC(=O)NC1CCNCC1.CC(C)(C)OC(=O)NCCC(NC(=O)c1ccc(Cl)c(NC(=O)c2cc3cnc(S(C)(=O)=O)nc3[nH]c2=O)c1)c1ccccc1>>CC(C)(C)OC(=O)NCCC(NC(=O)c1ccc(Cl)c(NC(=O)c2cc3cnc(N4CCC(NC(=O)OC(C)(C)C)CC4)nc3[nH]c2=O)c1)c1ccccc1,,O,,CN(C)C=O,,val
US20110166132A1,COC(=O)C(C)Br.c1ccc2[nH]ccc2c1>>COC(=O)C(C)n1ccc2ccccc21,,CN(C)C=O,O,[H-].[Na+],,val
US20070142452A1,CCOC(=O)c1[nH]c2ccccc2c1Cc1cccc2ccccc12.COCCBr>>CCOC(=O)c1c(Cc2cccc3ccccc23)c2ccccc2n1CCOC,,CN(C)C=O,,[H-].[Na+],,val
US20140155428A1,CC(C)(C)OC(=O)Nc1ccc(C(=O)O)c(F)c1.COc1ccc([C@@H](O)Cc2c(Cl)c[n+]([O-])cc2Cl)cc1OC>>COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2F)cc1OC,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US20110230458A1,CCCCC(=O)Cc1ccc(OC2CCCCC2)cc1.CCOC(=O)C=O>>CCCCC(=O)C(c1ccc(OC2CCCCC2)cc1)C(O)C(=O)OCC,,C1CCOC1,,CCN(CC)CC,,val
US05491167,CCC(Oc1c(C)cccc1C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O3)[C@H]21>>CCC(Oc1c(C)cccc1C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100240702A1,COC(=O)CC1(Nc2ccccc2N)CCCCC1.O=C(n1ccnc1)n1ccnc1>>COC(=O)CC1(n2c(=O)[nH]c3ccccc32)CCCCC1,,C1CCOC1,,,,val
US20140243283A1,O=C(OO)c1cccc(Cl)c1.O=C1CCC2(CC1)c1cc(Br)ccc1-c1ccc(Br)cc12>>O=C1CCC2(CCO1)c1cc(Br)ccc1-c1ccc(Br)cc12,,ClCCl,,O=C([O-])O.[Na+],,val
US20150087699A1,Brc1ncnc2nc[nH]c12.C[C@@H](N)c1oc2ccccc2c(=O)c1-c1cccc(F)c1>>C[C@@H](Nc1ncnc2[nH]cnc12)c1oc2ccccc2c(=O)c1-c1cccc(F)c1,,CC(C)(C)O,,CCN(C(C)C)C(C)C,,val
US20050043354A1,CC(=O)N1CCC(NC2CCCNC2Cc2ccccc2)CC1.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CC(=O)N1CCC(NC2CCCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2Cc2ccccc2)CC1,CN(C)c1ccncc1,CC(Cl)Cl,ClCCl,CCN(CC)CC,,val
US04567184,BrBr.COC(=O)c1ccccc1C>>COC(=O)c1ccccc1CBr,,ClC(Cl)(Cl)Cl,,O,,val
US20070066605A1,CCOC(=O)c1nc(Cl)ncc1N>>CCOC(=O)c1ncncc1N,[Pd],CCN(CC)CC,CO,[H][H],,val
US20140206663A1,CCOC(=O)C(C)N1C(=O)COc2cc(F)c(Br)cc21.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)C(C)N1C(=S)COc2cc(F)c(Br)cc21,,Cc1ccccc1,,,,val
US20070270385A1,CC(C)(C)OC(=O)NC[C@@H](O)CP(=O)(CC1CCCCC1)OC1OC(=O)c2ccccc21.Cl>>Cl.NC[C@@H](O)CP(=O)(CC1CCCCC1)OC1OC(=O)c2ccccc21,,C1COCCO1,,,,val
US20150111891A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2c(C)cccc2c1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2c(C)cccc2c1OS(=O)(=O)C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100125062A1,OC1C=C(c2cccnc2Oc2ccc(C(O)c3nc4ccccc4[nH]3)cc2)CC1>>OC1CCC(c2cccnc2Oc2ccc(C(O)c3nc4ccccc4[nH]3)cc2)C1,[Pd],C1CCOC1,,[H][H],,val
US20030109516A1,CS(=O)(=O)OCCCNC(=O)C(F)(F)F.Clc1ccc(C2=CCNCC2)cc1>>O=C(NCCCN1CC=C(c2ccc(Cl)cc2)CC1)C(F)(F)F,,CCO,,CCN(CC)CC,Cl,val
US20070123512A1,COCCN(CCOC)S(F)(F)F.Cc1cc(NC(=O)C(C)(O)COc2ccc(CCO)cc2)ccc1[N+](=O)[O-]>>Cc1cc(NC(=O)C(C)(O)COc2ccc(CCF)cc2)ccc1[N+](=O)[O-],,ClCCl,,O=C([O-])O.[Na+],,val
US20060148858A1,COC(=O)Cc1cccc(O)c1.OCc1cn(-c2ccc(C(F)(F)F)cn2)nc1C1CCCCC1>>O=C(O)Cc1cccc(OCc2cn(-c3ccc(C(F)(F)F)cn3)nc2C2CCCCC2)c1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20060004013A1,C=CC(=O)Cl.NC1CCc2ccccc21>>C=CC(=O)NC1CCc2ccccc21,,CCOC(C)=O,,C1CCOC1,O,val
US20100285145A1,CC(C)OC(=O)N1CCC(O)CC1.Clc1cc(N2CCc3ncccc32)ncn1>>CC(C)OC(=O)N1CCC(Oc2cc(N3CCc4ncccc43)ncn2)CC1,,COC(C)(C)C,,CN(C)C=O,[H-].[Na+],val
US20050038035A1,C=Cc1ccccn1.Cc1ccc(C2=C(C(=O)Nc3ccc(N)cc3)CCCC2)cc1>>Cc1ccc(C2=C(C(=O)Nc3ccc(NCCc4ccccn4)cc3)CCCC2)cc1,,CC(C)O,,CS(=O)(=O)O,,val
US20100324139A1,CCOC(=O)CC(CC(C)C)C[N+](=O)[O-]>>CC(C)CC(CC(=O)O)C[N+](=O)[O-],,C1CCOC1,O,[Li+].[OH-],,val
US20060111375A1,COc1cc2ccncc2cc1Br.OB(O)c1cccnc1>>COc1cc2ccncc2cc1-c1cccnc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050203081A1,COC(=O)c1cccnc1O.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Br)cnc1O,,ClCCl,,,,val
US20160168165A1,O=Cc1ccc(Br)s1.Sc1nc2ccccc2[nH]1>>O=Cc1ccc(Sc2nc3ccccc3[nH]2)s1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150038528A1,CC(C)(C)OC(=O)C(C)(C)CN.CCOC(=O)c1nc(C#N)c2cc(Oc3c(F)cccc3F)ccc2c1O>>CC(C)(C)OC(=O)C(C)(C)CNC(=O)c1nc(C#N)c2cc(Oc3c(F)cccc3F)ccc2c1O,,CCO,,,,val
US20060293319A1,CC(=O)Cl.Nc1ccc(NC(=O)N2CCCC(C3(Cc4cccc(Cl)c4)C(=O)Nc4cc(Cl)ccc43)C2)cc1>>CC(=O)Nc1ccc(NC(=O)N2CCCC(C3(Cc4cccc(Cl)c4)C(=O)Nc4cc(Cl)ccc43)C2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20080146565A1,CC#N.O.c1ccc2[nH]ccc2c1>>NC(=O)c1c[nH]c2ccccc12,Cl,,,,,val
US20080108620A1,C[C@@H](c1ccc(C(=O)NCCC(=O)OC(C)(C)C)cc1)n1nc(-c2cc(Cl)cc(Cl)c2)cc1-c1cnc2ccccc2c1>>C[C@@H](c1ccc(C(=O)NCCC(=O)O)cc1)n1nc(-c2cc(Cl)cc(Cl)c2)cc1-c1cnc2ccccc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04997840,Cn1cc(OC(=O)c2ccccc2)c(=O)c2ccc(F)cc21>>Cn1cc(O)c(=O)c2ccc(F)cc21,,ClCCl,,C1CCNCC1,,val
US20150025087A1,CO.O=C(O)c1cc(F)c(Cl)nc1Cl>>COC(=O)c1cc(F)c(Cl)nc1Cl,CN(C)C=O,,,O=S(Cl)Cl,,val
US20140088094A1,COCC1CO1.O=[N+]([O-])c1cc(NS(=O)(=O)c2ccc(F)cc2)c(F)cc1F>>COCC1CN(S(=O)(=O)c2ccc(F)cc2)c2cc([N+](=O)[O-])c(F)cc2O1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20100056490A1,CC(C)(C)c1cccc(CN2C(=O)O[C@@H]3[C@@H]2CS(=O)(=O)C[C@H]3Cc2cc(F)c(N)c(I)c2)c1.COC(OC)N(C)C>>CN(C)C=Nc1c(F)cc(C[C@@H]2CS(=O)(=O)C[C@H]3[C@H]2OC(=O)N3Cc2cccc(C(C)(C)C)c2)cc1I,,Cc1ccccc1,,,,val
US05342934,CC(C)(C)OC(=O)NC(=O)OC(C)(C)C.COC(=O)c1cc(CBr)cc(CBr)c1>>COC(=O)c1cc(CBr)cc(CN(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US06083961,CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(CO)c2C)cn1.CS(=O)(=O)Cl>>CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(CCl)c2C)cn1,,CN(C)C=O,ClC(Cl)Cl,CCN(CC)CC,O=C([O-])O.[Na+],val
US06395766B1,CCc1c[nH]c2c1C(=O)CC(C)(C)C2.Clc1ncccn1>>CCc1cn(-c2ncccn2)c2c1C(=O)CC(C)(C)C2,[Cu]Br,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04094906,CC(C)(C)C(=O)Cl.NNc1ccc(Cl)cc1>>CC(C)(C)C(=O)N(N)c1ccc(Cl)cc1,,O,,Cl,c1ccncc1,val
US20040138203A1,CS(=O)(=O)Cl.OCCN1CCN(c2nccc3ccccc23)CC1>>ClCCN1CCN(c2nccc3ccccc23)CC1,,CN(C)C=O,,CCN(CC)CC,,val
US20100249139A1,CC(c1ccc(N)cc1Cl)C(O)(c1ccnc(Cl)c1)C(F)(F)F.CCOC(=O)c1ccc(S(=O)(=O)Cl)cc1>>CCOC(=O)c1ccc(S(=O)(=O)Nc2ccc(C(C)C(O)(c3ccnc(Cl)c3)C(F)(F)F)c(Cl)c2)cc1,,c1ccncc1,,,,val
US03941802,NN.Nc1ccc(Cl)cc1C(=O)c1ccccc1F>>NN=C(c1cc(Cl)ccc1N)c1ccccc1F,,OCCOCCO,,O,,val
US20080119469A1,COC(=O)C1CCOC1=O.NC(N)=S>>O=C1NC(=S)NC(=O)C1CCO,,CCO,,CCN(CC)CC,,val
US20120178748A1,CN(C(=O)OC(C)(C)C)c1ccc2c(c1[N+](=O)[O-])OCCO2>>CNc1ccc2c(c1[N+](=O)[O-])OCCO2,,CCOCC,Cl,,,val
US20060094767A1,C[C@@]1(Cn2cc([N+](=O)[O-])nc2Cl)CO1.Oc1ccc(N2CCN(Cc3ccc(OC(F)(F)F)cc3)CC2)cc1>>C[C@]1(COc2ccc(N3CCN(Cc4ccc(OC(F)(F)F)cc4)CC3)cc2)Cn2cc([N+](=O)[O-])nc2O1,,CN(C)C=O,,[H-].[Na+],,val
US20130237566A1,CC(C)(C)OC(=O)CBr.CC(C)(C)[Si](C)(C)O[C@@H]1c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2OC[C@@H]1N>>CC(C)(C)OC(=O)CN[C@H]1COc2cc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)ccc2[C@H]1O[Si](C)(C)C(C)(C)C,,CC#N,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04673529,N#Cc1ccc(-c2ccc(O)cc2)cc1.OCCCBr>>N#Cc1ccc(-c2ccc(CCCO)cc2)cc1,,CCO,O,[Na+].[OH-],,val
US05236797,N#CCC#N.O=C1C=C(c2ccccc2)P(=O)(c2ccccc2)C(c2ccccc2)=C1>>N#CC(C#N)=C1C=C(c2ccccc2)P(=O)(c2ccccc2)C(c2ccccc2)=C1,C1CCNCC1,CCO,,,,val
US20160016948A1,C[C@H](Nc1cc(Cl)ncc1[N+](=O)[O-])c1ccc2[nH]cnc2c1>>C[C@H](Nc1cc(Cl)ncc1N)c1ccc2[nH]cnc2c1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20050143422A1,CCOC(=O)c1oc2cccc(CCCOC)c2c1C>>COCCCc1cccc2oc(C(=O)O)c(C)c12,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US05538988,Fc1cc2c(cc1F)C1OC1C2>>OC1Cc2cc(F)c(F)cc2C1,[Pd],CCO,,,,val
US20140038889A1,CC(C)(C)OC(=O)N1CCC(Oc2ncnc(Cl)c2F)CC1.Cc1nc(S(C)(=O)=O)ccc1O>>Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)OC(C)(C)C)CC2)c1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120065214A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=Nc1c(O)ccc2ccccc12>>N#Cc1ccccc1/C=C\C(=O)O,,C1CCOC1,O,[Na+].[OH-],,val
US20080114019A1,CC(N)CCO.O=[N+]([O-])c1cnc2cccnc2c1Cl>>O=[N+]([O-])c1cnc2cccnc2c1NCCCO,,ClCCl,O,CCN(CC)CC,,val
US06013662,CC1(c2ccccc2)CCC(=O)CC1(O)C(=O)O>>CC1(c2ccccc2)CCC(=O)C=C1C(=O)O,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100261728A1,FC(F)(F)c1ccc(C2NCCc3ccccc32)cc1.O=C=Nc1ccc(F)cc1>>O=C(Nc1ccc(F)cc1)N1CCc2ccccc2C1c1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020019371A1,CC(C)(C)OC(=O)Nc1ccc(Cl)c(CC(=O)O)c1.CCI>>CCOC(=O)Cc1cc(NC(=O)OC(C)(C)C)ccc1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040242890A1,ClCc1ccccc1.O=C1CNC(=O)N1c1cccc(I)c1>>O=C1CN(Cc2ccccc2)C(=O)N1c1cccc(I)c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20140094474A1,CCOC(=O)C(N)=NO.Cc1cc(C(=O)O)nn1C>>CCOC(=O)c1noc(-c2cc(C)n(C)n2)n1,,ClCCl,,CC(C)N=C=NC(C)C,,val
US20150232460A1,CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)NC1CCCC1(C)N.Fc1cc(C(F)(F)F)cnc1F>>CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)NC1CCCC1(C)Nc1ncc(C(F)(F)F)cc1F,,CS(C)=O,,CCN(C(C)C)C(C)C,Cl,val
US20140088124A1,COC(=O)C1(C=O)CCOCC1>>COC(=O)C1(CO)CCOCC1,,CO,,[BH4-].[Na+],,val
US20120309757A1,CC(C)c1cccc(/C=N/[S@@](=O)C(C)(C)C)c1.C[Si](C)(C)C(F)(F)F>>CC(C)c1cccc([C@@H](N[S@@](=O)C(C)(C)C)C(F)(F)F)c1,,C1CCOC1,,,,val
US20060135578A1,CCOP(=O)(CP(=O)(OCC)OCC)OCC.COc1cc(C(=O)Nc2nn(-c3ccccc3)cc2C=O)ccc1OCc1nc(-c2ccccc2)oc1C>>CCOP(=O)(/C=C/c1cn(-c2ccccc2)nc1NC(=O)c1ccc(OCc2nc(-c3ccccc3)oc2C)c(OC)c1)OCC,,CN(C)C=O,,O,[H-].[Na+],val
US20030105074A1,COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(C#N)cc23)cc1Cl.O=C1NC(=O)c2ccccc21>>COc1ccc(CNc2nnc(N3CCC(N4C(=O)c5ccccc5C4=O)CC3)c3ccc(C#N)cc23)cc1Cl,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040127574A1,CCOC(=O)C(Cc1ccc(F)cc1)C(O)c1ccc(F)cc1>>O=C(O)C(Cc1ccc(F)cc1)C(O)c1ccc(F)cc1,,CO,,Cl,[Na+].[OH-],val
US20130274266A1,CC(C)(C)OC(=O)NC1=N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)Cn2c(C#N)cnc21>>C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)Cn2c(C#N)cnc2C(N)=N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120208815A1,CC1(O)CCCNC1.O=[N+]([O-])c1cnccc1Cl>>CC1(O)CCCN(c2ccncc2[N+](=O)[O-])C1,,CN(C)C=O,,CCN(CC)CC,,val
US20080293749A1,CC1=CC(=O)NC1=O.NCc1ccccc1N>>CC1(NCc2ccccc2N)CC(=O)NC1=O,,CCOC(C)=O,,,,val
US06358970B1,C=C(C)CC1CCN(Cc2ccccc2)C1.O=[Os](=O)(=O)=O>>CC(=O)CC1CCN(Cc2ccccc2)C1,O=[Os](=O)(=O)=O,CCOC(C)=O,O,C1CCOC1,,val
US05210239,COCOc1cc(OC)c(OC)c(OC)c1C=O.O=C(OO)c1cccc(Cl)c1>>COCOc1cc(OC)c(OC)c(OC)c1O,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20040209921A1,CC(=O)OCc1ncccc1S(=O)c1ccccc1>>O=S(c1ccccc1)c1cccnc1CO,,CO,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20100305096A1,CC(C)(C)OC(=O)N1CC(C(=O)N2CC[C@@H](O)C2)C1>>O=C(C1CNC1)N1CC[C@@H](O)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090209556A1,CCOC(=O)c1cnn(-c2cccc(-c3ccccc3O)n2)c1C(F)(F)F.FC(F)(Br)c1ccc(Br)cc1>>CCOC(=O)c1cnn(-c2cccc(-c3ccccc3OC(F)(F)c3ccc(Br)cc3)n2)c1C(F)(F)F,,CN(C)C=O,,[H-].[Na+],,val
US20120029190A1,CC(C)[Si](OC1=CCC(c2cc(F)cc(C#N)c2)CC1)(C(C)C)C(C)C.O=C1CCC(=O)N1Br>>N#Cc1cc(F)cc(C2CCC(=O)C(Br)C2)c1,,C1CCOC1,,O,CC(=O)[O-].[Na+],val
US20100130492A1,CNc1ncc(-c2nc(N3CCOCC3)c3nc(Cl)n(CC4CC4)c3n2)cn1.C[C@H]1CNC[C@@H](C)N1>>CNc1ncc(-c2nc(N3CCOCC3)c3nc(N4C[C@H](C)N[C@H](C)C4)n(CC4CC4)c3n2)cn1,,CO,ClCCl,CS(C)=O,,val
US20060166977A1,COc1ccc2nccc(C#C[Si](C)(C)C)c2n1>>C#Cc1ccnc2ccc(OC)nc12,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20060155128A1,CC(C)(C)OC(=O)N1CCC(O)CC1.COc1c(Cl)ncnc1Cl>>COc1c(Cl)ncnc1OC1CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US03933835,OC1(c2ccc(C(OC(c3ccccc3)c3ccc(C4(O)C5CC6CC(C5)CC4C6)cc3)c3ccccc3)cc2)C2CC3CC(C2)CC1C3>>Oc1ccc(C2C3CC4CC(C3)CC2C4)cc1,[Pd],,,CC(=O)O,[H][H],val
US05770594,CC(C)(C)C=O.Nc1ccc(Cl)cc1>>CC(C)(C)CNc1ccc(Cl)cc1,,CC(=O)O,O,[BH4-].[Na+],,val
US20130253022A1,[N-]=[N+]=NCC(F)(F)c1ccccc1F>>NCC(F)(F)c1ccccc1F,[Pd],CCOC(C)=O,,,,val
US20020111332A1,CI.COc1cc(CN(C)C)cc(OC)c1O>>COc1cc(C[N+](C)(C)C)cc(OC)c1O.[I-],,C1COCCO1,,,,val
US20120088755A1,COc1ccc2c(c1)CCN(C1CCNCC1)C(=O)N2.Cc1cc(Oc2cc(Cl)ncn2)cc2[nH]c([C@@H]3CCCO3)nc12>>COc1ccc2c(c1)CCN(C1CCN(c3cc(Oc4cc(C)c5nc([C@@H]6CCCO6)[nH]c5c4)ncn3)CC1)C(=O)N2,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20160038504A1,CCO.Nc1nc(Cl)cnc1Br>>CCOc1ncc(Cl)nc1N,,CCO,ClCCl,C,C[O-].[Na+],val
US20140303139A1,CC1(C)OCC(CNS(C)(=O)=O)O1.COC(=O)c1cc(Cl)nc(Cl)n1>>COC(=O)c1cc(N(CC2COC(C)(C)O2)S(C)(=O)=O)nc(Cl)n1,,CN(C)C=O,,O,[H-].[Na+],val
US20150344473A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2C#N)CC1.Clc1ncnc2[nH]c(-c3ccc(N4CCOCC4)cc3)nc12>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(-c3ncnc4[nH]c(-c5ccc(N6CCOCC6)cc5)nc34)cc2C#N)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US05741796,COC(=O)c1ccc(OCCCNC(=S)Nc2ccccc2[N+](=O)[O-])cc1>>COC(=O)c1ccc(OCCCNC(=S)Nc2ccccc2N)cc1,[Pd],CO,,N,,val
US20060258860A1,CO[C@@H]1C[C@@H](c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)N(C(=O)OCc2ccccc2)C1>>CO[C@H]1CN[C@H](c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)C1,[Pd],CO,,,,val
US20160000771A1,CC1(C)CCNCC1.Cc1cc(Cl)nc(Cl)c1C(=O)OC(C)(C)C>>Cc1cc(Cl)nc(N2CCC(C)(C)CC2)c1C(=O)OC(C)(C)C,,ClCCCl,,CCN(C(C)C)C(C)C,,val
US20140228405A1,Cl.N[C@@H]1C[C@H]1c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)cc1.O=Cc1ccccc1>>Cl.O=C(N[C@@H](Cc1ccccc1)C(=O)Nc1ccc([C@@H]2C[C@H]2NCc2ccccc2)cc1)OCc1ccccc1,,C1CCOC1,CO,[BH4-].[Na+],,val
US20140256933A1,Cl.NC1=N[C@@]2(c3ccccc3)CN(c3ncc(F)cn3)C[C@H]2CS1>>Cl.NC1=N[C@@]2(c3ccccc3)CN(c3ncc(F)cn3)C[C@H]2CS1,,CCOC(C)=O,,,,val
US20100125089A1,CC(N)(C#N)Cn1cc2c(Cl)cc(Cl)c(Cl)c2n1.O=C(Cl)c1ccc(I)cc1>>CC(C#N)(Cn1cc2c(Cl)cc(Cl)c(Cl)c2n1)NC(=O)c1ccc(I)cc1,,C1CCOC1,,,,val
US05834463,CC1(C)OC(=O)CC(=O)O1.O=C(Cl)CN1C(=O)c2ccccc2C1=O>>COC(=O)CC(=O)CN1C(=O)c2ccccc2C1=O,,ClCCl,,Cl,c1ccncc1,val
US04166128,COC(=O)C(O)c1ccccc1Nc1c(Cl)cccc1Cl>>O=C(O)C(O)c1ccccc1Nc1c(Cl)cccc1Cl,,CCO,,[Na+].[OH-],,val
US20140235620A1,CC(C)(C)[S@](N)=O.Cc1n[nH]cc1C=O>>Cc1n[nH]cc1/C=N/[S@](=O)C(C)(C)C,,C1CCOC1,CCOC(C)=O,,,val
US20100105906A1,CCOC(=O)CBr.O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCNc2ccccc21>>O=C(O)CN1CCN(C(=O)c2cccnc2Oc2cc(Cl)ccc2Cl)c2ccccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,[Na+].[OH-],val
US20130079335A1,CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(-c3cccc(C=O)c3)ccc2-n2c(C)nnc21.CN1CCNCC1>>CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(-c3cccc(CN4CCN(C)CC4)c3)ccc2-n2c(C)nnc21,,CC(=O)O,ClCCl,O=C([O-])O.[Na+],,val
US20120245210A1,COCOc1ccc(-c2csc(CCC(=O)O)c2-c2ccc(Cl)cc2OC)cc1>>COc1cc(Cl)ccc1-c1c(-c2ccc(O)cc2)csc1CCC(=O)O,,C1CCOC1,O,Cl,,val
US20110190280A1,CCNc1nc(-c2cc(C)cc(OC)c2)c(-c2ccnc(Cl)n2)s1.Nc1ccc(N2CCOCC2)c(F)c1>>CCNc1nc(-c2cc(C)cc(OC)c2)c(-c2ccnc(Nc3ccc(N4CCOCC4)c(F)c3)n2)s1,,OCC(F)(F)F,,,,val
US20100216810A1,N#Cc1c(Oc2ccc(F)c(NC(=O)C(F)(F)F)c2)ccc2nc(NC(=O)C3CC3)sc12>>N#Cc1c(Oc2ccc(F)c(N)c2)ccc2nc(NC(=O)C3CC3)sc12,,CCO,,CO,[BH4-].[Na+],val
US20060074084A1,COc1cccc(-c2c(C(=O)O)[nH]c3ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)cc23)c1.NCCN1CCOCC1>>COc1cccc(-c2c(C(=O)NCCN3CCOCC3)[nH]c3ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)cc23)c1,,CO,ClCCl,,,val
US20100022508A1,O=C1c2ccccc2C(=O)N1CC(F)(F)C(=O)O>>O=C1c2ccccc2C(=O)N1CC(F)(F)CO,,C1CCOC1,O,CCOC(C)=O,,val
US05268386,CCOC(=O)COc1cc(O)c2c(c1)NC1(CCCCC1)CC2=O.CI>>COc1cc(OCC(=O)O)cc2c1C(=O)CC1(CCCCC1)N2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140024650A1,N[C@H]1CCOC[C@@H]1COc1ccc(-n2cc(Cl)cn2)cc1.O=S(=O)(Cl)C1CC1>>O=S(=O)(N[C@H]1CCOC[C@@H]1COc1ccc(-n2cc(Cl)cn2)cc1)C1CC1,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,Cl,val
US20050014940A1,NCN1CC(C(=O)OCc2ccccc2)C=CO1.O=Cc1ccccc1>>O=C(OCc1ccccc1)C1C=CON(CNCc2ccccc2)C1,,CO,,O,[BH4-].[Na+],val
US20150284367A1,Cc1ccc(Nc2cc(Cl)nnc2C(N)=O)nc1N(C)C.NCCN>>Cc1ccc(Nc2cc(NCCN)nnc2C(N)=O)nc1N(C)C,,CS(C)=O,,,,val
US06313153B1,COCOc1ccc(CCNC(=O)CC#N)cc1.O=Cc1cccnc1>>COCOc1ccc(CCNC(=O)/C(C#N)=C/c2cccnc2)cc1,,CCO,,C1CCNCC1,,val
US05972947,C1CC2(CCN1)OCCO2.Clc1ccnc(Cl)n1>>Clc1nccc(N2CCC3(CC2)OCCO3)n1,,CCO,,CCN(CC)CC,,val
US20120010191A1,CN1CCN(Cc2ccccc2)CC1CF>>CN1CCNCC1CF,[Pd],CO,,,,val
US05254549,CC(=O)Oc1c(C(C)(C)C)cc(CCCOS(=O)(=O)c2ccc(C)cc2)cc1C(C)(C)C.OCCCc1cccnc1>>CC(C)(C)c1cc(CCCOCCCc2cccnc2)cc(C(C)(C)C)c1O,,C1CCOC1,CN(C)P(=O)(N(C)C)N(C)C,[H-].[Na+],,val
US20080242685A1,CC(C)(C)OC(=O)N1CC=C(c2c[nH]c3c(C#N)nc(-c4ccccc4)cc23)CC1.[OH-]>>CC(C)(C)OC(=O)N1CC=C(c2c[nH]c3c(C(N)=O)nc(-c4ccccc4)cc23)CC1,,[Na+],[OH-],CCO,,val
US06200978B1,CCI.O=Cc1ccccc1C(=O)O>>COC(=O)c1cccc(C=O)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120197027A1,CN1CCN(CCCN)CC1.COc1cc2c(Oc3ccc4[nH]cc(C)c4c3)ncnc2cc1OC[C@H]1CO1>>COc1cc2c(Oc3ccc4[nH]cc(C)c4c3)ncnc2cc1OC[C@H](O)CNCCCN1CCN(C)CC1,,CN(C)C=O,,,,val
US20070155704A1,CCOC(=O)C(CCCCC(CC)(CC)COC1CCCCO1)(CCCCC(CC)(CC)COC1CCCCO1)C(=O)OCC>>CCOC(=O)C(CCCCC(C)(C)CO)(CCCCC(C)(C)CO)C(=O)OCC,,Cl,O,CCO,,val
US20040198725A1,C[Si](C)(C)CCOCCl.c1nc2nc(N3CCOCC3)nc(N3CCOCC3)c2[nH]1>>C[Si](C)(C)CCOCn1cnc2nc(N3CCOCC3)nc(N3CCOCC3)c21,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20050277668A1,CCOC(=O)c1c(C)cc(Cl)nc1C>>Cc1cc(Cl)nc(C)c1C(=O)O,,CCO,,[Na+].[OH-],,val
US20110201629A1,CC(C)(C)OC(=O)NC1CCC(CN2C(=O)C(C)(C)c3ccccc32)CC1>>CC1(C)C(=O)N(CC2CCC(N)CC2)c2ccccc21,,CO,,C1COCCO1,Cl,val
US06649643B1,CC(C)C(O)(c1ccc2cc(-c3nn[nH]c3[Si](C)(C)C)ccc2c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CC(C)C(O)(c1ccc2cc(-c3c[nH]nn3)ccc2c1)c1c[nH]cn1,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100204285A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2[C@H]1C=O.NCc1ccccc1>>CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2[C@H]1CNCc1ccccc1,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20150194612A1,Cc1ccc(B2OC(C)(C)C(C)(C)O2)c(C)n1.Cc1ccnc(Br)c1>>Cc1ccnc(-c2ccc(C)nc2C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20010053851A1,COC(=O)C(CC1CCCC1)c1ccc(C#CCN(C)C)cc1>>CN(C)CC#Cc1ccc(C(CC2CCCC2)C(=O)O)cc1,,CO,O,[Li+].[OH-],,val
US20150175623A1,CCOC(=O)[C@@H](Cc1ccccc1OC1CCCCO1)Oc1ncnc2sc(CCCOC)c(-c3ccc(OCCN4CCN(C)CC4)c(Cl)c3C)c12>>CCOC(=O)[C@@H](Cc1ccccc1O)Oc1ncnc2sc(CCCOC)c(-c3ccc(OCCN4CCN(C)CC4)c(Cl)c3C)c12,,CCO,,Cl,,val
US04963673,COC(=O)CCCCCN.O=C1CCCCCN1>>CN1CCCCCC1=O,,O,,,,val
US04438128,NCCNc1ncnc2nc[nH]c12.c1ccc(OCC2CO2)cc1>>OC(CNCCNc1ncnc2nc[nH]c12)COc1ccccc1,,ClCCl,,CN(C)C=O,O,val
US04970219,CC(=O)N1CCc2cc(Nc3cnccc3[N+](=O)[O-])ccc21>>CC(=O)N1CCc2cc(Nc3cnccc3N)ccc21,,CCO,,,,val
US20050090493A1,BrCCc1ccccc1.Clc1nccc(Nc2ccccc2)n1>>Clc1nccc(N(CCc2ccccc2)c2ccccc2)n1,,CN(C)C=O,,[H-].[Na+],,val
US04876267,CC(=O)Cl.CCOc1ccc(NS(=O)(=O)c2ccc3[nH]cc(CCN)c3c2)cc1>>CCOc1ccc(NS(=O)(=O)c2ccc3[nH]cc(CCNC(C)=O)c3c2)cc1,,CN(C)C=O,,CCN(CC)CC,,val
US20150301368A1,CCCCCc1ccc(-c2cc(OCC(=O)OCC)cc(OCC(=O)OCC)c2)cc1>>CCCCCc1ccc(-c2cc(OCCO)cc(OCCO)c2)cc1,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US06040331,CCO.O=C(O)CCc1c(-c2ccccc2)[nH]c2cc(Cl)ccc12>>CC(=O)N1c2cc(Cl)cc3c2C(CCC3=O)C1c1ccccc1,[Zn],,,Cl,,val
US20110183947A1,COC(=O)c1cccc(-c2noc(C(=O)CCCCCCc3ccccc3)n2)n1>>O=C(O)c1cccc(-c2noc(C(=O)CCCCCCc3ccccc3)n2)n1,,CCOCC,,,,val
US20070129347A1,COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC1CCC(c2ccccc2)(N(C)C)CC1.C[Si](C)(C)Cl>>COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC1CCC(c2ccccc2)(N(C)C)CC1.Cl,,CCC(C)=O,,CCOCC,,val
US20090306038A1,Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.Nc1nc(Cl)cc(Cl)n1>>Cc1ccc(C)n1-c1nc(Cl)cc(Cl)n1,,Cc1ccccc1,,,,val
US20120029187A1,Nc1ccccc1CO.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=S(=O)(Nc1ccccc1CO)C(F)(F)F,,ClC(Cl)Cl,,CCN(CC)CC,O,val
US20020147343A1,CC(C)(C)OC(=O)NCCOc1cc(-c2ccc[nH]2)c2c3c(ccc(F)c13)NC2=O>>NCCOc1cc(-c2ccc[nH]2)c2c3c(ccc(F)c13)NC2=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04123450,CCN.O=C(Cl)Oc1ccccc1>>CCNC(=O)Oc1ccccc1,,ClCCl,,[Na+].[OH-],,val
US20120295283A1,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H](C[C@H](CC[C@H](NS(=O)(=O)c2ccc(C)cc2)C(=O)OC(C)(C)C)N=[N+]=[N-])O[C@H]1n1cnc2c(N)nc(NCCNC(=O)OC(C)(C)C)nc21>>Cc1ccc(S(=O)(=O)N[C@@H](CC[C@@H](C[C@H]2O[C@@H](n3cnc4c(N)nc(NCCNC(=O)OC(C)(C)C)nc43)[C@H](O)[C@@H]2O)N=[N+]=[N-])C(=O)OC(C)(C)C)cc1,,CO,,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US03957783,CC(=O)N(C)c1sccc1C(=O)c1ccccc1F>>CNc1sccc1C(=O)c1ccccc1F,,CCO,,Cl,N,val
US20090298816A1,COC(=O)c1c(N)ccc2ncccc12>>Nc1ccc2ncccc2c1C(=O)O,,C1COCCO1,CO,[Na+].[OH-],,val
US04382937,CC(=O)NC1CCNC1.CCOC(=O)c1cn(CCF)c2nc(S(=O)(=O)CC)c(F)cc2c1=O>>CCOC(=O)c1cn(CCF)c2nc(N3CCC(NC(C)=O)C3)c(F)cc2c1=O,,CCO,,CCN(CC)CC,,val
US05543298,COc1cc2c(cc1OC)C(=O)C(C)(C)C2.COc1ccc(Br)cc1>>COc1ccc(C2(O)c3cc(OC)c(OC)cc3CC2(C)C)cc1,,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US20140315888A1,CC1(NC(=O)OC(C)(C)C)CNC1.O=C(Cl)OCc1ccccc1>>CC1(NC(=O)OC(C)(C)C)CN(C(=O)OCc2ccccc2)C1,,ClCCl,,Cl,,val
US20090156603A1,COC(=O)CCSc1cnc(Nc2nc(C3CCN(C(C)=O)CC3)cs2)c(Oc2ccccc2)c1.Clc1ncnc2sccc12>>CC(=O)N1CCC(c2csc(Nc3ncc(Sc4ncnc5sccc45)cc3Oc3ccccc3)n2)CC1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US04046768,Nc1ncc(I)s1.O=C(Cl)Cl>>O=C=Nc1ncc(I)s1,,CCOC(C)=O,,,,val
US20120252801A1,CCN1CC(C)(C)OC(=O)C1CC(=O)O.Cc1noc(C)c1N>>CCN1CC(C)(C)OC(=O)C1CC(=O)Nc1c(C)noc1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05189036,O=C(c1ccc(-n2ccnc2)cc1)N1CCN(Cc2ccccc2)CC1>>O=C(c1ccc(-n2ccnc2)cc1)N1CCNCC1,[Pd],CCO,O,,,val
US20150238473A1,Cc1ccc(S(=O)(=O)OCCc2ccccc2C(C)(C)C)cc1.OC(c1ccccc1)(c1ccccc1)C1CCNCC1>>CC(C)(C)c1ccccc1CCN1CCC(C(O)(c2ccccc2)c2ccccc2)CC1,,O,,CC#N,,val
US20050020617A1,CC(C)(CC(=O)O)N1C(=O)c2ccccc2C1=O.NCc1ccccn1>>CC(C)(CC(=O)NCc1ccccn1)N1C(=O)c2ccccc2C1=O,,ClCCl,,,,val
US20140045823A1,CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ncc(Br)cn2)C2CC2)CC1.CC(C)[Si](c1ncc(B2OC(C)(C)C(C)(C)O2)o1)(C(C)C)C(C)C>>CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ncc(-c3cnco3)cn2)C2CC2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20130005707A1,C1COCCN1.Cc1cc([N+](=O)[O-])cnc1Cl>>Cc1cc([N+](=O)[O-])cnc1N1CCOCC1,,O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US06673968B1,Cc1cc(S(C)(=O)=O)c(S(C)(=O)=O)cc1C(=O)NC(=N)N.Cl>>Cc1cc(S(C)(=O)=O)c(S(C)(=O)=O)cc1C(=O)NC(=N)N.Cl,,CCO,,,,val
US20120232052A1,CC(C)(C)OC(=O)NCCn1ccc2cc(C(=O)N3CCC(Oc4ccc(Cl)cc4)CC3)ccc21>>NCCn1ccc2cc(C(=O)N3CCC(Oc4ccc(Cl)cc4)CC3)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130172384A1,COc1cc(F)c(B(O)O)cc1F.Cn1nc(-c2ccc(Br)cc2F)n(C[C@@H]2CCN(C(=O)C3CC3)C2)c1=O>>COc1cc(F)c(-c2ccc(-c3nn(C)c(=O)n3C[C@@H]3CCN(C(=O)C4CC4)C3)c(F)c2)cc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20130143870A1,CN(C)C=O.Cl.O=C1CCCN(Cc2ccccc2)CC1.O=P(Cl)(Cl)Cl>>Cl.O=CC1=C(Cl)CCN(Cc2ccccc2)CC1,,ClCCl,,,,val
US20050203146A1,CC(C)(C)c1ccc2[nH]c(Nc3cccnc3Oc3ccccc3C(C)(C)C)nc2c1.CI>>Cn1c(Nc2cccnc2Oc2ccccc2C(C)(C)C)nc2ccc(C(C)(C)C)cc21,,C1CCOC1,,[H-].[Na+],,val
US20090239845A1,Cc1cc(N2CCN(CC(C)C)CC2=O)nn1Cc1cc(Cl)ccc1OCc1ccccc1>>Cc1cc(N2CCN(CC(C)C)CC2=O)nn1Cc1cc(Cl)ccc1O,,ClCCl,,BrB(Br)Br,,val
US05658922,CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CC[C@H](C(C)=O)[C@@]4(C)CC[C@@H]32)C1>>CC(=O)OC1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CC[C@H](C(C)O)[C@@]4(C)CC[C@@H]32)C1,,CCO,ClCCl,[BH4-].[Na+],,val
US20140329794A1,CC(C)(C)OC(=O)N1CCNCC1.O=Cc1cccc(C(=O)O)c1>>CC(C)(C)OC(=O)N1CCN(Cc2cccc(C(=O)O)c2)CC1,,CO,,[BH3-]C#N.[Na+],,val
US20150191465A1,CC[Mg]Br.CSc1nc(Cl)c(C#N)c(Cl)n1>>CCc1nc(SC)nc(Cl)c1C#N,,C1CCOC1,,CCOCC,,val
US05246948,CCCCCCCC(=O)NCCCCCO.CS(=O)(=O)Cl>>CCCCCCCC(=O)NCCCCCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20160207890A1,COC(=O)c1nn(C)cc1N.Nc1c(F)cc(C#Cc2ccccc2)cc1F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COC(=O)c1nn(C)cc1NC(=O)Nc1c(F)cc(C#Cc2ccccc2)cc1F,,Cc1ccccc1,,CCN(CC)CC,,val
US20100298340A1,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.O=[N+]([O-])c1ccccc1O>>O=CCc1ccccc1[N+](=O)[O-],,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20160068510A1,COC(=O)c1cccc(OC2CCC(C)N(C(=O)c3ccccc3-n3nccn3)C2)c1>>CC1CCC(Oc2cccc(C(=O)O)c2)CN1C(=O)c1ccccc1-n1nccn1,,CO,O,[Li+].[OH-],,val
US20080249080A1,CCOC(=O)C1Nc2ccccc2S(=O)(=O)n2cccc21>>O=S1(=O)c2ccccc2NC(CO)c2cccn21,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160137606A1,CC(C)(C)OC(=O)N[C@@H](CC1CC1)C(=O)O.CN(C)C=O>>COC(=O)[C@H](CC1CC1)NC(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060025433A1,CI.CN(C)C=O.COC(=O)c1cccc(N)c1Cl>>COC(=O)c1cccc(N(C)C)c1Cl,,O,,O=C([O-])[O-].[K+].[K+],,val
US20150105372A1,CC(=O)OC(C)=O.COc1nc2ccc(C(O)C3CCNCC3)cc2c(Cl)c1Cc1ccc(C(F)(F)F)cc1>>COc1nc2ccc(C(O)C3CCN(C(C)=O)CC3)cc2c(Cl)c1Cc1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(CC)CC,,val
US20150353533A1,CC(C)(C)OC(=O)N[C@H]1CNc2ncnc(Cl)c2NC1=O>>CC(C)(C)OC(=O)N[C@H]1CNc2ncncc2NC1=O,[Pd],CCO,CCOC(C)=O,CO,,val
US20040180911A1,COC(=O)[C@@H]1C[C@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1>>COC(=O)[C@@H]1C[C@@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1,,CCOC(C)=O,,COC(C)(C)C,,val
US04659727,CCOC=C(C(=O)OCC)C(=O)OCC.Nc1cc(O)cc(O)c1>>CCOC(=O)C(=CNc1cc(O)cc(O)c1)C(=O)OCC,,CCO,,,,val
US20060252637A1,CC(C)(Br)C(=O)Br.Cc1ccccc1C>>Cc1cc2c(cc1C)C(=O)C(C)C2,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20160136172A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(OCc4ccccc4)c(C(=O)NCc4ccc(F)cc4)n3)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(O)c(C(=O)NCc4ccc(F)cc4)n3)cc12,[Pd],CO,,,,val
US20050124671A1,Fc1ccc(C=C2CCC3(CC2)OCCO3)cc1>>Fc1ccc(CC2CCC3(CC2)OCCO3)cc1,[Pd],CCOC(C)=O,,[H][H],,val
US20050043317A1,CC(=O)NCC1CN(c2ccc(I)c(F)c2)C(=O)O1.OCc1ccc(B(O)O)cc1>>CC(=O)NCC1CN(c2ccc(-c3ccc(CO)cc3)c(F)c2)C(=O)O1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,CCO,O=C([O-])[O-].[K+].[K+],val
US20040063820A1,CC(C)NC(C)C.S=C=S>>CC(C)N(C(=S)S)C(C)C,,CC(C)O,,,,val
US20120214767A1,CC1(C)OC[C@@H](CO)O1.Oc1ccc2c(c1)CCc1nc(-c3onc(-c4ccccc4)c3C(F)(F)F)oc1-2>>OC[C@H](O)COc1ccc2c(c1)CCc1nc(-c3onc(-c4ccccc4)c3C(F)(F)F)oc1-2,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100048564A1,CC(C)(C)OC(=O)NCc1cc(Oc2cc(F)cc(F)c2)ccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)NCc1cc(Oc2cc(F)cc(F)c2)ccc1N,[Fe],O,,CCO,[Cl-].[NH4+],val
US20150322008A1,COC(=O)c1ccc2[nH]ccc2c1Cl>>O=C(O)c1ccc2[nH]ccc2c1Cl,,CO,,[Li+].[OH-],,val
US20070049560A1,C1CCNC1.O=C(CBr)OCc1ccccc1>>CC(=O)OC(c1ccccc1)N1CCCC1,,COC(C)(C)C,,,,val
US05616599,BrCc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.CC(C)OCc1nc(C(C)(C)O)c(C(=O)OC(C)C)[nH]1>>CC(C)OCc1nc(C(C)(C)O)c(C(=O)OC(C)C)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,CC(=O)N(C)C,CCOC(C)=O,O,CC(C)(C)[O-].[K+],val
US20140350034A1,BrCc1ccc2ccccc2c1.Clc1ncc2cc[nH]c2n1>>Clc1ncc2ccn(Cc3ccc4ccccc4c3)c2n1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080207654A1,CCCCc1nc(C)c(-c2cccs2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCCc1nc(C)c(-c2cccs2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,O,,CS(C)=O,[Cl-].[Na+],val
US03960880,CCCCCc1cc(OC)c2c(c1)OC(C)(C)C=C2c1ccncc1>>CCCCCc1cc(OC)c2c(c1)OC(C)(C)CC2c1ccncc1,[Pd],CCO,,,,val
US04971990,COc1ccc(CCNC(=O)C(F)(F)F)cc1S(N)(=O)=O.Cl>>COc1ccc(CCN)cc1S(N)(=O)=O.Cl,,CO,,[Na+].[OH-],,val
US05389486,BrC(c1ccccc1)c1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>[Br-].c1ccc(C(c2ccccc2)[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,CC#N,CCOCC,,,val
US04645765,CC(=O)OC(C)=O.NC(=O)OCC1c2c(O)cc(CO)cc2N2CC3NC3C1(O)O2.c1ccncc1>>CC(=O)OCc1cc(OC(C)=O)c2c(c1)N1CC3C(N3C(C)=O)C(O)(O1)C2COC(N)=O,,c1ccncc1,,,,val
US20080153810A1,Nc1ccc2[nH]nc(-n3ccnc3)c2c1.O=C(O)Cc1ccc(Oc2ccccc2)cc1.On1nnc2ccccc21>>O=C(Cc1ccc(OCc2ccccc2)cc1)Nc1ccc2[nH]nc(-n3ccnc3)c2c1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,ClCCCl,val
US20050234083A1,CC(C)(C)c1cc(N)no1.Cn1c(Cl)nc2cc([N+](=O)[O-])ccc21>>Cn1c(Nc2cc(C(C)(C)C)on2)nc2cc([N+](=O)[O-])ccc21,Cl,CC(C)O,,,,val
US20150038488A1,C[C@@H](Oc1nc(B2OC(C)(C)C(C)(C)O2)cc2ncn(C3CC3)c12)[C@H]1CNC(=O)C1.FC(F)(F)c1ncc(Br)s1>>C[C@@H](Oc1nc(-c2cnc(C(F)(F)F)s2)cc2ncn(C3CC3)c12)[C@H]1CNC(=O)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,ClCCl,N#N,O=C([O-])[O-].[Na+].[Na+],val
US20030087952A1,CCOC(=O)CN(C)C(=O)C#Cc1ccccc1>>CCOC(=O)C1C(c2ccccc2)=CC(=O)N1C,,C1CCOC1,ClCCl,O,,val
US20020077320A1,CCOC(Cc1ccc(OCCN2c3ccccc3Sc3ccccc32)cc1)C(=O)OC>>CCOC(Cc1ccc(OCCN2c3ccccc3Sc3ccccc32)cc1)C(=O)O,,CO,,[Na+].[OH-],,val
US20120101083A1,CCOc1ncc(-c2nc(-c3ccc4c(c3)CCN(C(=O)CNC(=O)OC(C)(C)C)CC4)no2)cc1C#N>>CCOc1ncc(-c2nc(-c3ccc4c(c3)CCN(C(=O)CN)CC4)no2)cc1C#N,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140288081A1,C=CCC1(O)CCN(C(=O)OC(C)(C)C)CC1.OO>>CC(C)(C)OC(=O)N1CCC(O)(CCCO)CC1,,O,,C1CCOC1,[Na+].[OH-],val
US20020049226A1,CCOC(=O)C(=O)Nc1cc(Cl)c(Oc2ccc(O)c(C=O)c2)c(Cl)c1.NC1CCc2ccccc21>>CCOC(=O)C(=O)Nc1cc(Cl)c(Oc2ccc(O)c(CNC3CCc4ccccc43)c2)c(Cl)c1,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05877193,COCN(c1nc(-c2cccc(-c3ccccc3)c2)cs1)S(=O)(=O)c1ccc(C)cc1>>Cc1ccc(S(=O)(=O)Nc2nc(-c3cccc(-c4ccccc4)c3)cs2)cc1,,C1CCOC1,,Cl,O,val
US20140011795A1,CC1(C)C(=O)CCC1NC(=O)OCc1ccccc1>>CC1(C)C(=O)CCC1N,[Pd],CO,,,,val
US20070015744A1,CC(C)(C)OC(=O)N1CC(CO)C1.O=c1[nH]c2c(O)cccc2n1Cc1ccccc1>>CC(C)(C)OC(=O)N1CC(C(Cc2ccccc2)Oc2cccc3[nH]c(=O)[nH]c23)C1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020061883A1,CCN(CC)CC.CNOCC(=O)O.Cc1ccc(Cl)cc1N=C=S>>CCN1OCC(=O)N(c2cc(Cl)ccc2C)C1=S,,ClC(Cl)Cl,,Cl,,val
US20130267493A1,CC(=O)N1CCC(c2ccc(Br)cc2)CC1.COC(=O)c1c[nH]c2cc(Cl)c(B3OCC(C)(C)CO3)cc12>>COC(=O)c1c[nH]c2cc(Cl)c(-c3ccc(C4CCN(C(C)=O)CC4)cc3)cc12,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20120258950A1,CCO/C=C(/C(=O)OCC)C(=O)C(F)(F)F.NN>>CCOC(=O)c1cn[nH]c1C(F)(F)F,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US05221754,C=C(CO)Sc1ccccc1.O=C(OO)c1cccc(Cl)c1>>C=C(CO)S(=O)c1ccccc1,,ClCCl,,,,val
US20100029644A1,O=Cc1ccc(Cl)nc1.c1ccc([C@H]2CNCCO2)cc1>>Clc1ccc(CN2CCO[C@@H](c3ccccc3)C2)cn1,,CC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20130059883A1,COC(=O)c1cc(C#N)c(O)nc1C.O=P(Cl)(Cl)Cl>>COC(=O)c1cc(C#N)c(Cl)nc1C,,O=P(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20160068496A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=S(=O)(CCCF)Nc1cccc(Br)c1F>>CC1(C)OB(c2cccc(NS(=O)(=O)CCCF)c2F)OC1(C)C,,Cc1ccccc1,,ClCCl,,val
US20080269267A1,Cc1ccc(N)cc1C#N.Cl.O=N[O-]>>Cc1ccc(NN)cc1C#N.Cl,,Cl,O,Cl[Sn]Cl,,val
US20140171312A1,COC(=O)C(F)(F)F.COc1c(F)cc(Br)cc1F>>COc1c(F)cc(C(=O)C(F)(F)F)cc1F,,C1CCOC1,,Cl,,val
US04010177,NNC(=O)CO.O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1F)=NCC(=S)N2>>O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1F)=NCc1nnc(CO)n1-2,,CCCCO,,,,val
US06395733B1,Cc1ccc2c(c1C)NCC2.Clc1ncnc2cnccc12>>Cc1ccc2c(c1C)N(c1ncnc3cnccc13)CC2.Cl,,CC(C)O,,c1ccncc1,,val
US20130023663A1,BrP(Br)Br.COC(=O)CCCOc1cc([N+](=O)[O-])c(CO)cc1OC>>COC(=O)CCCOc1cc([N+](=O)[O-])c(CBr)cc1OC,,C1CCOC1,,,,val
US20130296555A1,CC(C)(C)OC(=O)N1CCN(C(=S)NN)CC1.O=C(O)[C@@H]1CC[C@@H]2CN1C(=O)N2OCc1ccccc1>>CC(C)(C)OC(=O)N1CCN(C(=S)NNC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150175562A1,CCN(CC)S(F)(F)F.COC(=O)[C@@H]1C[C@@H](NC(=O)c2nc(CC3CCCCC3)c(-c3cc(C(C)(C)C)cc(C(C)(C)O)c3)s2)C1>>COC(=O)[C@@H]1C[C@@H](NC(=O)c2nc(CC3CCCCC3)c(-c3cc(C(C)(C)C)cc(C(C)(C)F)c3)s2)C1,,ClCCl,,,,val
US20100273744A1,Nc1cc[nH]n1.O=C(Cl)c1c(F)cccc1F>>O=C(Nc1cc[nH]n1)c1c(F)cccc1F,,CC#N,,CCN(CC)CC,,val
US20080051418A1,CC(C)(O)C#N.CC(C)Oc1cc(CCCOc2nc(Cc3ccccc3)sc2CO)n(Cc2ccc(Cl)cc2Cl)n1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CC(C)Oc1cc(CCCOc2nc(Cc3ccccc3)sc2CC(=O)O)n(Cc2ccc(Cl)cc2Cl)n1,,C1CCOC1,,CCCCP(CCCC)CCCC,,val
US20120058985A1,CC(=O)Nc1nc(Cl)cc(Cl)n1.Nc1cc(F)c(O)cc1F>>CC(=O)Nc1nc(Cl)cc(Oc2cc(F)c(N)cc2F)n1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04170597,O[C@@H]1CCC[C@H]1Oc1cccc(C(F)(F)F)c1>>O=C1CCCC1Oc1cccc(C(F)(F)F)c1,,CCOCC,ClCCl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20140018319A1,CC(C)(C)[Si](C)(C)O[C@@H]1CN(c2cc(C#N)cc(N)c2Cl)CC[C@H]1N.COC(=O)OC(=O)OC>>COC(=O)N[C@@H]1CCN(c2cc(C#N)cc(N)c2Cl)C[C@H]1O[Si](C)(C)C(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20120270838A1,CC1(C)OC[C@H](Cn2ccc3c(C=O)cccc32)O1.CS(=O)(=O)N1CCC2(CC1)N=C(C1CCCCC1)NC2=O>>CC1(C)OC[C@H](Cn2ccc3c(C(O)CS(=O)(=O)N4CCC5(CC4)N=C(C4CCCCC4)NC5=O)cccc32)O1,,C1CCOC1,CN1CCCN(C)C1=O,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20120010207A1,CC(C)(C)OC(=O)c1cc(Cl)c(Sc2ccc(Cl)c(Cl)c2)cc1F>>O=C(O)c1cc(Cl)c(Sc2ccc(Cl)c(Cl)c2)cc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US04996218,BrCCCCCBr.OCCCc1nc2ccccc2n1Cc1ccccc1>>BrCCCCCOCCCc1nc2ccccc2n1Cc1ccccc1,,ClCCl,O,[Na+].[OH-],,val
US20150266895A1,Nc1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c2cc(Cl)ncc12.O=C(n1ccnc1)n1ccnc1.OCC(F)F>>O=C(Nc1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c2cc(Cl)ncc12)OCC(F)F,,C1CCOC1,,c1c[nH]cn1,,val
US20040077638A1,COC(=O)CC1c2ccccc2C(=O)N(C)c2cc(C(=O)O)ccc21.NCCCNc1ccccn1>>COC(=O)CC1c2ccccc2C(=O)N(C)c2cc(C(=O)NCCCNc3ccccn3)ccc21,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CCN=C=NCCCN(C)C,val
US20080188467A1,COC(=O)c1c(OC)cc(OC)nc1N>>COc1cc(OC)c(C(=O)O)c(N)n1,,CCO,O,[K+].[OH-],,val
US20100069307A1,CCOC(=O)Cn1cnc2nc(N3CCNCC3)nc(Cl)c21>>CCOC(=O)Cn1cnc2nc(N3CCNCC3)ncc21,[Pt],CO,,,,val
US20140113898A1,CC(C)=CC(=O)O.N#Cc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1>>CC(C)(CC(=O)O)Sc1cccc(C(F)(F)F)c1,,CCOC(C)=O,,II,,val
US20100280029A1,COc1ncc(-c2cc(-c3ncc(CN4C[C@H](C)O[C@H](C)C4)o3)c3cnn(S(=O)(=O)c4ccccc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F>>COc1ncc(-c2cc(-c3ncc(CN4C[C@H](C)O[C@H](C)C4)o3)c3cn[nH]c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F,,CC(C)O,,[Na+].[OH-],,val
US20100035883A1,COC(=O)c1cccc2c1C(=O)C(c1ccccc1)C(c1ccccc1)N2.NN>>O=c1[nH]nc2c3c(cccc13)NC(c1ccccc1)C2c1ccccc1,,O,,,,val
US20090318690A1,COCOc1ccc(C(=O)OC)c(O)c1.O=C1CCC(=O)N1Br>>COCOc1cc(O)c(C(=O)OC)cc1Br,,CC#N,,O,,val
US20050130954A1,C1CNCCN1.Clc1ccnc2ccoc12>>c1cc(N2CCNCC2)c2occc2n1,,CO,,,,val
US05753664,CCOC(=O)c1ncn(Cc2ccc(C(=O)c3ccc(Cl)cc3)cc2)c1C(OCC)OCC>>CCOC(=O)c1ncn(Cc2ccc(C(=O)c3ccc(Cl)cc3)cc2)c1C=O,,CC(=O)O,O,,,val
US20060004092A1,CC(C)(C)OC(=O)CC(C#N)C#N.FC(F)(F)CCCBr>>CC(C)(C)OC(=O)CC(C#N)(C#N)CCCC(F)(F)F,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130090309A1,COC(=O)c1ccc2c(c1)CCC2=O.Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cncs2)c1>>COC(=O)c1ccc2c(c1)CCC2(O)c1ncc(-c2cc(C)cc(Nc3cc(C(F)(F)F)ccn3)n2)s1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20090192162A1,CCOC(=O)COc1ccc(Sc2cc(C#Cc3ccc(S(C)(=O)=O)cc3)cc(OCC3CCCC3)c2)cc1C>>Cc1cc(Sc2cc(C#Cc3ccc(S(C)(=O)=O)cc3)cc(OCC3CCCC3)c2)ccc1OCC(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20140205537A1,CC(C)Oc1cc(Cl)c([N+](=O)[O-])cn1.CCOC(=O)CC(=O)OCC>>CCOC(=O)C(C(=O)OCC)c1cc(OC(C)C)ncc1[N+](=O)[O-],,CS(C)=O,,[H-].[Na+],[Cl-].[NH4+],val
US20020161031A1,CN(C)c1cccc([N+](=O)[O-])c1.O=C1CCC(=O)N1Cl>>CN(C)c1cccc([N+](=O)[O-])c1Cl,,CN(C)C=O,,,,val
US20050197396A1,CCO.C[C@H](N)C(=O)O.O=S(=O)(O)c1ccc(Cl)cc1>>CCOC(=O)[C@H](C)N.O=S(=O)(O)c1ccc(Cl)cc1,,CCO,,,,val
US04025502,CC(C)N=NC1(Cl)CCCCC1.[N-]=[N+]=[N-]>>CC(C)N=NC1(N=[N+]=[N-])CCCCC1,,CO,,O,,val
US05143920,CC(C)C(=O)Cl.CCCC(=O)c1cnc2c(OC)cccc2c1Nc1ccc(O)cc1C>>CCCC(=O)c1cnc2c(OC)cccc2c1Nc1ccc(OC(=O)C(C)C)cc1C,,c1ccncc1,,,,val
US20130197059A1,COC(=O)c1cc(O)cc(OCCCNC(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)NCCCOc1cc(O)cc(C(=O)O)c1,,O,,Cl,[Na+].[OH-],val
US20150225449A1,CC(=O)N1c2cc(C#N)ccc2N(Cc2c(C)ccc3ccccc23)C(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H]1C.Cl>>CC(=O)N1c2cc(C#N)ccc2N(Cc2c(C)ccc3ccccc23)C(=O)[C@@H](N)[C@@H]1C.Cl,,C1COCCO1,CCOCC,,,val
US20090318385A1,CCOC(=O)c1c(C(F)F)nn2c(OC)ccc(COC(C)=O)c12>>COc1ccc(CO)c2cc(C(F)F)nn12,,CCO,,[K+].[OH-],,val
US20100305096A1,CC(C)(O)C1CCNCC1.Cn1c(C(=O)O)nc2c(N3CCOCC3)nc(-n3c(C4CC4)nc4ccccc43)nc21>>Cn1c(C(=O)N2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(-n3c(C4CC4)nc4ccccc43)nc21,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140323435A1,BrBr.Cc1csc2c(O)nc(-c3ccncc3)nc12>>Cc1c(Br)sc2c(O)nc(-c3ccncc3)nc12,,ClC(Cl)Cl,,,,val
US20040167121A1,CC(C)(C)OC(=O)n1[nH]c(=O)c2ccc(N)cc21.Clc1nc(Nc2cc(C3CC3)n[nH]2)c2cc(I)ccc2n1>>O=c1[nH][nH]c2cc(Nc3nc(Nc4cc(C5CC5)n[nH]4)c4cc(I)ccc4n3)ccc12,,CN1CCCC1=O,,C1CCOC1,O=C([O-])O.[Na+],val
US04539150,Br.O=C(NC1C(=O)Nc2ccccc2SC1c1ccccc1)OCc1ccccc1>>Br.NC1C(=O)Nc2ccccc2SC1c1ccccc1,,CC(=O)O,,CCOCC,,val
US20150119373A1,CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C5(C)CC5)CC[C@]4(C(=O)N4CCC(C(=O)NCCN5CCOCC5)CC4)CC[C@]23C)C1(C)C>>CC1([C@@H]2CC[C@]3(C(=O)N4CCC(C(=O)NCCN5CCOCC5)CC4)CC[C@]4(C)[C@H](CC[C@@H]5[C@@]6(C)CC[C@H](O)C(C)(C)[C@@H]6CC[C@]54C)[C@@H]23)CC1,,C1CCOC1,ClCCl,CO,,val
US20150191472A1,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)OC[C@@H]1[C@H]2OC(C)(C)O[C@H]2[C@H](c2c[nH]c3c(N=[N+]=[N-])ncnc23)N1C(=O)OC(C)(C)C>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)OC[C@@H]1[C@H]2OC(C)(C)O[C@H]2[C@H](c2c[nH]c3c(N)ncnc23)N1C(=O)OC(C)(C)C,[Pd],CO,,[H][H],,val
US06498254B1,Cc1ccc(C)c(CSc2ccccn2)c1.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(C)c(CS(=O)(=O)c2ccccn2)c1,,ClC(Cl)Cl,,O,,val
US20080070894A1,Cc1cccn2ccnc12>>CC1CCCn2ccnc21,[Ni],CCCCO,,,,val
US04159375,O=P(Cl)(Cl)Cl.O=c1ncc(-c2ccccc2Cl)n[nH]1>>Clc1ncc(-c2ccccc2Cl)nn1,,CN(C)C=O,,ClC(Cl)Cl,,val
US20090048109A1,COC(=O)c1cc(N)nc(-c2cc(F)c(Cl)cc2F)n1.O=C1CCC(=O)N1Cl>>COC(=O)c1nc(-c2cc(F)c(Cl)cc2F)nc(N)c1Cl,,CC#N,,,,val
US05821240,CSc1ncc2ncnc(Cl)c2n1.Nc1ccc(F)c(Cl)c1>>CSc1ncc2ncnc(Nc3ccc(F)c(Cl)c3)c2n1,,C1COCCO1,,,,val
US04001419,Cl.O=C(Oc1ccccc1)N1CCC2(CC1)c1ccccc1Oc1ccccc12>>Cl.c1ccc2c(c1)Oc1ccccc1C21CCNCC1,,O,,CCO,[K+].[OH-],val
US20040220159A1,C[C@]12CC[C@H]3[C@@H](CC(CO)C4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)Nc1ccc(C(F)(F)F)cc1>>C=C1C[C@H]2[C@@H]3CC[C@H](C(=O)Nc4ccc(C(F)(F)F)cc4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12,,C1COCCO1,Cl,,,val
US20070099944A1,CC(=O)CC(=O)Nc1ccc2[nH]nc(Br)c2c1.NC(N)=O.O=Cc1ccc(F)cc1>>CC1=C(C(=O)Nc2ccc3[nH]nc(Br)c3c2)C(c2ccc(F)cc2)NC(=O)N1,,CC#N,,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US20100261772A1,CC1(C)CC(=C(c2ccccc2)c2ccc(O)cc2)CC(C)(C)C1.CCOC(=O)CBr>>CCOC(=O)COc1ccc(C(=C2CC(C)(C)CC(C)(C)C2)c2ccccc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150225367A1,O=C1c2ccccc2C(=O)N1CCS(=O)(=O)NC1CCN(c2ccc(-c3c[nH]c4cc(F)ccc34)cn2)CC1>>NCCS(=O)(=O)NC1CCN(c2ccc(-c3c[nH]c4cc(F)ccc34)cn2)CC1,,CCO,,NN,O,val
US20020052341A1,CC(Br)C(=O)c1cccc(Cl)c1.CC(C)(N)CO>>CC1NC(C)(C)COC1(O)c1cccc(Cl)c1,,CC#N,CCOC(C)=O,,,val
US20160095858A1,CC(=O)n1ccc(O)n1.CC(C)CBr>>CC(=O)n1ccc(OCC(C)C)n1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090076049A1,O=C(O)C=Cc1ccc(Cl)c(Cl)c1>>OC/C=C/c1ccc(Cl)c(Cl)c1,,Cc1ccccc1,,CC(C)C[AlH]CC(C)C,,val
US20160158207A1,CC(=O)N1CCc2c(c(Nc3cccc(C4=CCCCC4)c3)nn2CC2CC2)C1>>CC(=O)N1CCc2c(c(Nc3cccc(C4CCCCC4)c3)nn2CC2CC2)C1,[Pd],CCO,,,,val
US20150133498A1,COc1ccc2c(C)c(C(=O)O)oc2c1.Nc1ccccc1>>COc1ccc2c(C)c(C(=O)Nc3ccccc3)oc2c1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20090163524A1,CC(C)(C)OC(=O)NC1(C(=O)NC(CCS(N)(=O)=O)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1>>NC1(C(=O)NC(CCS(N)(=O)=O)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1,,CO,ClCCl,Cl,,val
US04103012,CCc1cc2ccccn2c1C(=O)c1ccc(OS(=O)(=O)c2ccc(C)cc2)cc1>>CCc1cc2ccccn2c1C(=O)c1ccc(O)cc1,,CCO,O,Cl,[Na+].[OH-],val
US20090054405A1,Brc1ccc2nc(NCC3CCCCC3)sc2c1.COc1ccc(S(=O)(=O)Nc2cc(B3OC(C)(C)C(C)(C)O3)cnc2Cl)cc1>>COc1ccc(S(=O)(=O)Nc2cc(-c3ccc4nc(NCC5CCCCC5)sc4c3)cnc2Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,O=C([O-])O.[Na+],,val
US20090136550A1,COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1>>COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1,,O,,Cl,,val
US20110201593A1,CC(=O)NCC(=O)O.CC(C)(C)OC(=O)N1CCC(Nc2c(N)cnc3c2ccn3S(=O)(=O)c2ccccc2)CC1>>CC(=O)NCC(=O)Nc1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1NC1CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090005344A1,OB(O)CCCCCBr.c1cc2nc[nH]c2cn1>>OB(O)CCCCCn1cnc2cnccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070155727A1,C1CNCCNC1.COC(=O)c1ccc(CBr)cc1>>COC(=O)c1ccc(CN2CCCNCC2)cc1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US05512581,COC(=O)c1ccc(O)nc1.ClCc1ccc2ccccc2n1>>COC(=O)c1ccc(OCc2ccc3ccccc3n2)nc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090197862A1,COC(=O)CCl.Ic1cn[nH]c1>>COC(=O)Cn1cc(I)cn1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20060116364A1,CCN(CC)c1cc(OC)ccc1-c1cc2ccc(OC)cc2n1C.O=C1CCC(=O)N1Cl>>CCN(CC)c1cc(OC)ccc1-c1c(Cl)c2ccc(OC)cc2n1C,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20100160255A1,CC1(C)CC2(CCCN(C3CCN(C(=O)c4cn(-c5ccccc5)nc4N)CC3)C2)C(=O)O1.CCN=C=O>>CCNC(=O)Nc1nn(-c2ccccc2)cc1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1,,c1ccncc1,,,,val
US20100062464A1,CI.Cc1cc(=O)n(-c2ccc(S(=O)(=O)O)cc2)[nH]1>>Cc1cc(=O)n(-c2ccc(S(=O)(=O)O)cc2)n1C,,CO,,,,val
US20130317245A1,CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](CO)[C@@H]1Cc1cccc(OCc2ccccc2)c1)O[Si](C)(C)C(C)(C)C.CS(=O)(=O)Cl>>CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](COS(C)(=O)=O)[C@@H]1Cc1cccc(OCc2ccccc2)c1)O[Si](C)(C)C(C)(C)C,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20040235808A1,C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]12.O=C(Cl)c1ccccc1Cl>>C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@H](OC(=O)c4ccccc4Cl)[C@@]3(C)CC[C@@H]12,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US03930949,CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)C(OC(C)=O)c3ccccc3)[C@H]2SC1>>CC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1,,O,,,,val
US20120071461A1,C1=C(c2ccncc2)CCC2(C1)OCCO2>>c1cc(C2CCC3(CC2)OCCO3)ccn1,,CO,,,,val
US04325201,CC(C)(C)CC(C)(C)n1sccc1=O.O=C1CCC(=O)N1Br>>CC(C)(C)CC(C)(C)n1scc(Br)c1=O,,ClC(Cl)Cl,,,,val
US20140163025A1,CC(C)(O)CCn1ccc2cc(OCc3ccccc3)ccc21>>CC(C)(O)CCn1ccc2cc(O)ccc21,[Pd],CO,,CCN(CC)CC,,val
US08501382B1,CC(O)CCO.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1>>CC(O)CCOS(=O)(=O)c1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US04562189,BrCCCCOc1ccccc1.O=CN1CCNCC1>>c1ccc(OCCN2CCNCC2)cc1,,CC(C)O,,,,val
US20110021522A1,COc1ccc2cc(C(=O)O)c(=O)oc2c1.Nc1ccccc1>>COc1cccc2cc(C(=O)Nc3ccccc3)c(=O)oc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04477671,CC(=O)OC(C)=O.CC(=O)Oc1ccc(C(CN(C(C)=O)C(C)(C)C)OC(C)=O)[n+]([O-])c1C>>CC(=O)OCc1nc(C(CN(C(C)=O)C(C)(C)C)OC(C)=O)ccc1OC(C)=O,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US04199592,COc1ccc(-c2nc([N+](=O)[O-])[nH]c2-c2ccc(OC)cc2)cc1.O=C(Cl)c1ccccc1>>COc1ccc(-c2nc([N+](=O)[O-])n(C(=O)c3ccccc3)c2-c2ccc(OC)cc2)cc1,,C1CCOC1,CCOCC,CCN(CC)CC,,val
US20050154024A1,CO.O=C(O)Cn1cnnn1>>COC(=O)Cn1cnnn1,,CO,,C1COCCO1,Cl,val
US03996209,C1N2CN3CN1CN(C2)C3.O=C(CCl)Nc1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1>>O=C1CN=C(c2ccccc2)c2cc([N+](=O)[O-])ccc2N1,,CCO,,,,val
US20030220368A1,COc1ncc(Cl)cc1C=O.c1ccc(OCC2CCNCC2)c(OCC2CCCCC2)c1>>COc1ncc(Cl)cc1CN1CCC(COc2ccccc2OCC2CCCCC2)CC1,,CC(=O)O,ClCCCl,O=C([O-])O.[Na+],,val
US20120322831A1,C=CCc1ccc(OC(=O)CC2OC(C)(C)OC2=O)c(OC)c1>>C=CCc1ccc(OC(=O)CC(O)C(=O)O)c(OC)c1,,C1CCOC1,,Cl,,val
US20080255197A1,COC(=O)c1cc(C#N)ccc1CBr.Cc1cccnc1CNCc1ncccc1C(C)C>>COC(=O)c1cc(C#N)ccc1CN(Cc1ncccc1C)Cc1ncccc1C(C)C,,CC#N,,CCN(C(C)C)C(C)C,,val
US20100227859A1,CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(I)cc12)C(=O)OC(C)(C)C.CCCC[Sn](CCCC)(CCCC)c1cnc(CC(C)C)s1>>CC(C)Cc1ncc(-c2ccc3oc4cc(S(=O)(=O)N[C@H](C(=O)OC(C)(C)C)C(C)C)ccc4c3c2)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20120010182A1,COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3ccc(-c4ccccc4C(F)(F)F)cc3-c3ccnnc3)cc2F)c(OC)c1>>O=S(=O)(Nc1nncs1)c1cc(Cl)c(Oc2ccc(-c3ccccc3C(F)(F)F)cc2-c2ccnnc2)cc1F,,C1COCCO1,Cl,,,val
US20100240642A1,CC(=O)Cl.CC(C)(C)c1ccc(-c2c(C(=O)OCc3ccccc3)n(Cc3cccc(N4CCNCC4)c3)c3ccccc23)cc1>>CC(=O)N1CCN(c2cccc(Cn3c(C(=O)O)c(-c4ccc(C(C)(C)C)cc4)c4ccccc43)c2)CC1,,ClCCl,,CCOC(C)=O,,val
US20040102453A1,CS(=O)(=O)O.Cc1ccc(NC(=O)c2ccc(CN3CCNCC3)cc2)cc1Nc1nccc(-c2cccnc2)n1>>CS(=O)(=O)O.Cc1ccc(NC(=O)c2ccc(CN3CCNCC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,,CCO,,CCOC(C)=O,,val
US20160166560A1,CN(C(=O)n1cnc(-c2cccc(O)c2)c1)C1CCN(Cc2ccccc2)CC1.NS(=O)(=O)Cl>>CN(C(=O)n1cnc(-c2cccc(OS(N)(=O)=O)c2)c1)C1CCN(Cc2ccccc2)CC1.Cl,,CC(=O)N(C)C,,Br,,val
US06884868B1,CCCSC1CCN(c2ccc(N3CCN(c4ccc(C(=O)OCC)cc4)CC3)cc2)CC1>>CCCSC1CCN(c2ccc(N3CCN(c4ccc(C(=O)O)cc4)CC3)cc2)CC1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US04283539,Cc1[nH]c(=O)c2ccccc2c1CC(=O)O.O=P(Cl)(Cl)Cl>>Cc1nc(Cl)c2ccccc2c1CC(=O)O,,CCOC(C)=O,,,,val
US20110144068A1,CN(C)/C=C/C(=O)c1cccc([N+](=O)[O-])c1.NN>>O=[N+]([O-])c1cccc(-c2cc[nH]n2)c1,,CCO,,O,,val
US20030207911A1,COC(=O)c1cnc(N)c(N)c1.Cc1cc(C)c(S(=O)(=O)ON)c(C)c1.O=Cc1cccs1>>COC(=O)c1cc(N)c2nc(-c3cccs3)nn2c1,,C1COCCO1,CO,[K+].[OH-],,val
US20110172433A1,COC(=O)Cl.N=C1SCCN1Cc1ccc(Cl)nc1>>COC(=O)N=C1SCCN1Cc1ccc(Cl)nc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05712267,C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(S[C@H]3C[C@@H](C(=O)N4CCCN(CC(=O)OCc5ccc([N+](=O)[O-])cc5)CC4)N(C(=O)OCc4ccc([N+](=O)[O-])cc4)C3)[C@H](C)[C@H]12>>C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)N4CCCN(CC(=O)O)CC4)C3)[C@H](C)[C@H]12,,O,,C1CCOC1,Cl,val
US20060035908A1,NC(=O)C(CO)c1cnc(NC(=O)Nc2cccc(C(F)(F)F)c2)s1>>NCC(CO)c1cnc(NC(=O)Nc2cccc(C(F)(F)F)c2)s1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160222033A1,BrCc1ccccc1.Oc1cc(F)c(F)cc1Br>>Fc1cc(Br)c(OCc2ccccc2)cc1F,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080171742A1,Cc1cc(Cl)nc(Cl)n1.Nc1ccccn1>>Cc1cc(Nc2ccccn2)nc(Cl)n1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20070219210A1,CCOC(=O)C(=O)CC(=O)c1ccc(C)cn1.NNc1ccc(Cl)nn1>>CCOC(=O)c1cc(-c2ccc(C)cn2)n(-c2ccc(Cl)nn2)n1,,CCO,,Cl,[Na+].[OH-],val
US20140243353A1,COc1cc(C#Cc2ccccc2C)cnc1OC>>Cc1ccccc1CCc1c[nH]c(=O)c(O)c1,[Pd],CC(=O)O,CO,Br,O,val
US20050182139A1,CCN(CC)S(F)(F)F.CS(=O)c1ccc([C@H]2OC(c3ccccc3)=N[C@@H]2CF)cc1>>FCSc1ccc([C@H]2OC(c3ccccc3)=N[C@@H]2CF)cc1,,ClCCl,,,,val
US05356897,CN(C)C=C(C(=O)c1ccc(F)cc1)c1ccncc1.NO>>Fc1ccc(-c2oncc2-c2ccncc2)cc1,,CCO,,Cl,,val
US20040236109A1,CC(=O)N1c2ccc(N)cc2C(C)(c2ccccc2)CC1(C)C.COc1ccc(Br)c(C(=O)O)c1>>COc1ccc(Br)c(C(=O)Nc2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080234314A1,CC(=O)NCc1ccc2c(c1)OCO2.ClI>>CC(=O)NCc1cc2c(cc1I)OCO2,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US04841044,O=C(COc1ccccc1)N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(OP(=O)(c3ccccc3)c3ccccc3)CS[C@H]12.[SH-]>>O=C(COc1ccccc1)N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(S)CS[C@H]12,,CCN(C(C)C)C(C)C,CN(C)C=O,O,,val
US20160221945A1,N#Cc1ncc(F)c(-c2ccc(C(F)(F)F)nc2)c1F>>NCc1ncc(F)c(-c2ccc(C(F)(F)F)nc2)c1F,[Pd],CO,,Cl,[H][H],val
US20140296266A1,CC(C)(C)[S@](=O)N[C@@H](Cc1cc(F)cc(F)c1)c1ncc(Br)cc1Br>>N[C@@H](Cc1cc(F)cc(F)c1)c1ncc(Br)cc1Br,,ClCCl,,Cl,,val
US20100168080A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(Cl)cc2)CC1>>Clc1ccc(OC2CCNCC2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160228450A1,CNC(=O)[C@@H](CC(=O)OC(C)(C)C)NC(=O)OCC1c2ccccc2-c2ccccc21>>CNC(=O)[C@H](N)CC(=O)OC(C)(C)C,,ClCCl,,C1CCNCC1,,val
US04999381,CNC.COc1cc(NC(=O)C(C)(C)C)ccc1C(=O)Cl>>COc1cc(NC(=O)C(C)(C)C)ccc1C(=O)N(C)C,,C1CCOC1,,O,,val
US05686486,CCCC(O)c1ccccc1.O=c1cc(O)c2ccccc2o1>>CCCC(c1ccccc1)c1c(O)c2ccccc2oc1=O,,C1COCCO1,,CCOCC,FB(F)F,val
US20060128790A1,CCOC(=O)C1(CNc2ccc(OC)c(C)c2C)CCC1>>COc1ccc(NCC2(C(=O)O)CCC2)c(C)c1C,,CCO,,[K+].[OH-],,val
US20160002177A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.C[Si](C)(C)CCOCOc1cc(Br)cc2c(=O)n(COCC[Si](C)(C)C)cnc12>>CC1(C)OB(c2cc(OCOCC[Si](C)(C)C)c3ncn(COCC[Si](C)(C)C)c(=O)c3c2)OC1(C)C,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20120108582A1,CC(C)(C)OC(=O)NC[C@H]1OCCC[C@]1(N)C(=O)O.O=C(OCc1ccccc1)ON1C(=O)CCC1=O>>CC(C)(C)OC(=O)NC[C@H]1OCCC[C@]1(NC(=O)OCc1ccccc1)C(=O)O,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,O,val
US20110003787A1,COC[C@H](C)Oc1cc(O)cc(-c2ccc(C3=N[C@H]([C@H](C)O)CO3)[nH]2)c1.CS(=O)(=O)c1cnc(Cl)cn1>>COC[C@H](C)Oc1cc(Oc2cnc(S(C)(=O)=O)cn2)cc(-c2ccc(C3=N[C@H]([C@H](C)O)CO3)[nH]2)c1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US05011932,CC(=O)c1ccncc1.NNC(=O)Oc1ccccc1>>CC(=NNC(=O)Oc1ccccc1)c1ccncc1,,O,,CCO,Cl,val
US20140296068A1,CNn1cc(-c2cccnc2)nc1C.CSC(C)CC(=O)Cl>>CSC(C)CC(=O)N(C)n1cc(-c2cccnc2)nc1C,CN(C)c1ccncc1,ClCCCl,,O=C([O-])[O-].[K+].[K+],,val
US20140323475A1,O=C1OCCc2cn(Cc3cc(Cl)ccc3OCc3ccc(Cl)cc3F)c3cccc1c23.[Na+].[OH-]>>O=C([O-])c1cccc2c1c(CCO)cn2Cc1cc(Cl)ccc1OCc1ccc(Cl)cc1F.[Na+],,CCO,,O,,val
US05512431,NN.Nc1nc2c(nc(Br)n2[C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]1>>Nc1nc2c(nc(N)n2[C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]1,,O,,CO,,val
US20150232445A1,COc1cccc2c1CC[C@H](C)N2.O=C(Cl)C1CC1>>COc1cccc2c1CC[C@H](C)N2C(=O)C1CC1,,c1ccncc1,,ClCCl,,val
US06136854,C(=NC1CCCCC1)=NC1CCCCC1.CCCCCCCCCC(=O)O.CN(C)c1ccncc1.O=C1C=CCC1>>CCCCCCCCCC(=O)C1=C(C(=O)CCCCCCCCC)C(=O)CC1,CN(C)c1ccncc1,ClCCl,,,,val
US20140249126A1,CC(=O)c1cn(C)c2c(Br)cccc2c1=O.O=C(OO)c1cccc(Cl)c1>>CC(=O)Oc1cn(C)c2c(Br)cccc2c1=O,,ClCCl,,,,val
US20120329649A1,CC(C)(C)OC(=O)CNC(=O)c1ccc(/C=C/C(c2cc(Cl)c(Cl)c(Cl)c2)C(F)(F)F)cc1Br>>O=C(O)CNC(=O)c1ccc(/C=C/C(c2cc(Cl)c(Cl)c(Cl)c2)C(F)(F)F)cc1Br,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070225365A1,COC(=O)Cl.COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CNCc1cc([N+](=O)[O-])cc(C(F)(F)F)c1>>COC(=O)N(Cc1cc([N+](=O)[O-])cc(C(F)(F)F)c1)Cc1cc(C(F)(F)F)ccc1-c1cc(C(C)C)ccc1OC,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20130158009A1,CC(C)(C)OC(=O)N1CCC(N2CC[C@@H](OS(C)(=O)=O)C2=O)CC1.COC(=O)c1ccc(O)cn1>>COC(=O)c1ccc(O[C@H]2CCN(C3CCN(C(=O)OC(C)(C)C)CC3)C2=O)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150126485A1,N#Cc1cc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cnc1Cl.O[C@@H]1CCNC1>>N#Cc1cc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cnc1N1CC[C@@H](O)C1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US06017926,CCOC(=O)C=Cc1ccc(N)c(O)c1.O=C(Cl)CCl>>CCOC(=O)C=Cc1ccc(NC(=O)CCl)c(O)c1,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20090298834A1,CC(C)(C)OC(=O)NCCN(C(=O)C(F)(F)F)[C@@H]1CC[C@@H](CNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1>>NCCN(C(=O)C(F)(F)F)[C@@H]1CC[C@@H](CNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150018343A1,CC(=O)C(C)C(C)=O.CC(C)(C)OC(=O)N1Cc2n[nH]c(N)c2C1>>Cc1nc2c3c(nn2c(C)c1C)CN(C(=O)OC(C)(C)C)C3,,CC(=O)O,,,,val
US20100121052A1,COc1cc(Br)cc2cnc(Cl)nc12.Nc1ccc(S(N)(=O)=O)cc1>>COc1cc(Br)cc2cnc(Nc3ccc(S(N)(=O)=O)cc3)nc12,,CC(C)O,,,,val
US20110053933A1,CC(C)(C)OC(=O)N1CCC(O)CC1.CCc1cnc(Cl)nc1>>CCc1cnc(OC2CCN(C(=O)OC(C)(C)C)CC2)nc1,,O,,CN(C)C=O,[H-].[Na+],val
US20140221335A1,COC(=O)C(C)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1>>CC(C(=O)O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1,,C1COCCO1,,O,[Li+].[OH-],val
US20140065103A1,COC(=O)c1sccc1N.COCCBr>>COCCNc1ccsc1C(=O)OC,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,[I-].[K+],val
US20060106084A1,OC(c1cccc(OCc2ccccc2)c1)c1nn(C2CCCC2)c2ccccc12>>O=C(c1cccc(O)c1)c1nn(C2CCCC2)c2ccccc12,[Pd],CCO,,O=C[O-].[NH4+],,val
US04731447,CC(C)(C)NC(=O)c1ncccc1CCc1cccc(Cl)c1.O=S(=O)(O)O>>O=C(O)c1ncccc1CCc1cccc(Cl)c1,,CCCCCC,CCOC(C)=O,O,[Na+].[OH-],val
US20070060594A1,Cc1cnc(Cl)nc1Cl.N#CCc1ccccn1>>N#CCc1ccncn1,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20120322801A1,CC(C)(C)OC(=O)CS.O=C1OCCC1Br>>O=C(O)CSC1CCOC1=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040181064A1,Cc1c(N[C@@H](C)[C@H]2NCC[C@@H]2O[Si](C)(C)C(C)(C)C)ccc(C#N)c1Cl.O=C(Cl)Cl>>Cc1c(N2C(=O)N3CC[C@H](O[Si](C)(C)C(C)(C)C)[C@H]3[C@@H]2C)ccc(C#N)c1Cl,,Cc1ccccc1,ClCCl,CCN(C(C)C)C(C)C,,val
US20100130470A1,Brc1cnc2c(c1)CNCCN2.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCNc2ncc(Br)cc2C1,,ClCCl,,CCN(CC)CC,,val
US07294716B2,COC(=O)C(C)(C)CO.Cc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)C(C)(C)COS(=O)(=O)c1ccccc1C,CN(C)c1ccncc1,Cc1ccccc1,,c1ccncc1,,val
US20030027815A1,CC(C)(C)c1ccc(C(=O)Cl)cc1.O=C(c1ccc(C2CCCCC2)cc1)N1Cc2cccn2Cc2ccccc21>>CC(C)(C)c1ccc(C(=O)c2ccc3n2Cc2ccccc2N(C(=O)c2ccc(C4CCCCC4)cc2)C3)cc1,,O,,Cc1ccccc1C,,val
US20100256048A1,COC(=O)c1ccc(-c2cnc(N3CCN(CC4CCCC4)CC3)nc2)cc1.NN>>NNC(=O)c1ccc(-c2cnc(N3CCN(CC4CCCC4)CC3)nc2)cc1,,CCO,,O,,val
US20030199547A1,Clc1cccc(-c2onc3ccc(C4OCCO4)cc23)c1>>O=Cc1ccc2noc(-c3cccc(Cl)c3)c2c1,,CO,Cl,,,val
US20060135619A1,CCOC(=O)c1cc(Oc2ccccc2)ccc1[N+](=O)[O-]>>CCOC(=O)c1cc(Oc2ccccc2)ccc1N,[Pd],CO,,CCOC(C)=O,,val
US20150031679A1,COC(=O)c1ccc2nc(-c3ccccc3)c(N3CCC[C@@H]3CO)nc2c1>>O=C(O)c1ccc2nc(-c3ccccc3)c(N3CCC[C@@H]3CO)nc2c1,,CO,O,[Na+].[OH-],,val
US20060135526A1,CCOC(=O)CC(=O)OCC.Cc1cc(N)[nH]n1>>Cc1cc2n(n1)C(=O)CC(=O)N2,,CCO,,C,C[O-].[Na+],val
US20120202867A1,CC(=O)[C@@H]1C[C@H]1c1ccccc1Cl.CON>>CON=C(C)[C@@H]1C[C@H]1c1ccccc1Cl,,CO,O,Cl,c1ccncc1,val
US04939241,C[C@@H](OCc1ccccc1)[C@H](NC(=O)OCc1ccccc1)C(=O)O.O=C(CCO)OCc1ccccc1>>C[C@@H](OCc1ccccc1)[C@@H](C(=O)O)N(CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1,,ClCCl,,,,val
US20040110945A1,CCOC(=O)Cc1cc(Cl)c(Nc2nc3ccccc3o2)cc1F>>O=C(O)Cc1cc(Cl)c(Nc2nc3ccccc3o2)cc1F,,C1CCOC1,,[Na+].[OH-],,val
US20110077273A1,N#Cc1ccc(OCc2ccccc2C(=O)O)c(F)c1.O=C(Cl)C(=O)Cl>>N#Cc1ccc(OCc2ccccc2C(=O)Cl)c(F)c1,,ClCCl,,CN(C)C=O,,val
US20090069300A1,COC(=O)c1ccc(-c2ccc3c(c2)CCN(CCN2CCC[C@H]2C)C3=O)c(F)c1>>C[C@@H]1CCCN1CCN1CCc2cc(-c3ccc(C(=O)O)cc3F)ccc2C1=O,,CO,,,,val
US20110065708A1,C=O.Clc1ccc2nccn2n1>>OCc1cnc2ccc(Cl)nn12,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20050113397A1,C=O.CNC1CN(c2c(-c3ccccc3)c(C)c(C#N)c3nc4ncccc4n23)C1>>Cc1c(-c2ccccc2)c(N2CC(N(C)C)C2)n2c(nc3ncccc32)c1C#N,,C1CCOC1,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100216766A1,O=[N+]([O-])c1ccc(Oc2ccnc3cc[nH]c23)c(F)c1>>Nc1ccc(Oc2ccnc3cc[nH]c23)c(F)c1,[Fe],CC(=O)O,,,,val
US06326337B1,FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)I.Fc1cccc(I)c1>>Fc1cccc(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c1,[Cu],CS(C)=O,,,,val
US07074801B1,Fc1ccc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cc2-c2ccc3ncc(-c4cccs4)n3c2)cc1.O=C1CCC(=O)N1Br>>Fc1ccc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cc2-c2ccc3ncc(-c4ccc(Br)s4)n3c2)cc1,,CN(C)C=O,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20150291597A1,C#CCNc1nc(NC)nc(NCCC)n1.Cl>>C#CCNc1nc(NC)nc(NCCC)n1.Cl,,CCOCC,,,,val
US20090042854A1,C[C@@H](O[C@H]1CN2C(=O)C(=O)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.C[Mg]Br>>C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,C1CCOC1,Cc1ccccc1,,,val
US20150252022A1,Cc1cc2cc(-c3cnn(C4CCCCO4)c3)ccc2n1CC1CCNCC1.O=C(Cl)CCc1ccccc1>>Cc1cc2cc(-c3cnn(C4CCCCO4)c3)ccc2n1CC1CCN(C(=O)CCc2ccccc2)CC1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20130123230A1,CCOC(=O)C=C(OCC)c1ccc(OC)nc1OC>>CCOC(=O)CC(=O)c1ccc(OC)nc1OC,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US05221606,COc1cc(C=O)ccc1O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O.O=C(O)c1ccc(N2C(=O)CSC2=S)cc1>>COc1cc(C=C2SC(=S)N(c3ccc(C(=O)O)cc3)C2=O)ccc1O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O,C1CCNCC1,CCO,,[K],,val
US20100184815A1,BrCc1ccccc1.COC(=O)[C@H](C)O>>COC(=O)[C@H](C)OCc1ccccc1,,CN(C)C=O,Cl,[H-].[Na+],,val
US20040097485A1,COc1ccc(CN)cc1.N#Cc1cnc(Cl)c2cc(Br)sc12>>COc1ccc(CNc2ncc(C#N)c3sc(Br)cc23)cc1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20040087601A1,CI.Cc1cc(Cl)nc(Cl)n1>>CCc1cc(Cl)nc(Cl)n1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20100113502A1,CC1CCN(C(=O)c2ccc3[nH]c4c(c3c2)CN(C(=O)OC(C)(C)C)CC4)CC1.Cc1nc(CCl)cs1>>Cc1nc(Cn2c3c(c4cc(C(=O)N5CCC(C)CC5)ccc42)CN(C(=O)OC(C)(C)C)CC3)cs1,,CN(C)C=O,,[H-].[Na+],,val
US20090318690A1,CN(C)Cc1c(C2=CCOCC2)ccc2c(CCC3CCNCC3)noc12.N#Cc1ccc(C=O)s1>>CN(C)Cc1c(C2=CCOCC2)ccc2c(CCC3CCN(Cc4ccc(C#N)s4)CC3)noc12,,ClCCl,,O=C([O-])O.[Na+],,val
US20160024105A1,CC#N.CCOC(=O)c1cnc[nH]1.O=C1CCC(=O)N1Br>>CCOC(=O)c1[nH]cnc1Br.CCOC(=O)c1cnc[nH]1,,CC#N,,,,val
US20010010890A1,C=C(C(=O)OC12CC3CC(CC(C3)C1)C2)C(F)(F)F.C=CC(=O)OC1C2CC3C(=O)OC1C3C2>>C=C(C(=O)OC12CC3CC(CC(C3)C1)C2)C(F)(F)F.C=CC(=O)OC1C2CC3C(=O)OC1C3C2,,Cc1ccccc1,,,,val
US20110201592A1,CC(C)(C)OC(=O)N1CC[C@H](N)C1.Clc1ncc(Br)c(Cl)n1>>CC(C)(C)OC(=O)N1CC[C@H](Nc2nc(Cl)ncc2Br)C1,,C1COCCO1,,CCN(CC)CC,,val
US03935223,CCOC(=O)CC(=N)N.Cc1cccc(C=O)n1.O=C1CCCC(=O)C1>>CCOC(=O)C1=C(N)NC2=C(C(=O)CCC2)C1c1cccc(C)n1,,CCO,,CN(C)C=O,,val
US20100216860A1,COc1cccc(CBr)c1.COc1cccc2[nH]nc(N(COCC[Si](C)(C)C)S(=O)(=O)c3ccc(Cl)s3)c12>>COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030096759A1,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.O=C1CCC(=O)N1O>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)C1CC(=O)NC1=O,,COCCOC,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04237305,CC(=O)c1cccc(OCCC(N)C(=O)O)c1.CC(C)(C)OC(=O)ON=C(C#N)c1ccccc1>>CC(=O)c1cccc(OCCC(NC(=O)OC(C)(C)C)C(=O)O)c1,,C1COCCO1,O,CCN(CC)CC,O=C([O-])O.[Na+],val
US04851410,COc1c(N)c(=O)c1=O.NCCCCOn1cc(CN2CCCCC2)cn1>>Nc1c(NCCCCOn2cc(CN3CCCCC3)cn2)c(=O)c1=O,,CO,,,,val
US20090036448A1,CNC.Cc1nc(Cl)cc(Cl)n1.N[C@@H]1CC[C@H](NC(=O)c2ccc(F)c(F)c2)CC1.O=C(O)C(F)(F)F>>Cc1c(N[C@@H]2CC[C@H](NC(=O)c3ccc(F)c(F)c3)CC2)ncnc1N(C)C.O=C(O)C(F)(F)F,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20100022656A1,CC(C)(C)NC(CO)c1cc(Cl)c(N)c(C#N)c1.O=C(O)[C@](O)(C(=O)c1ccccc1)[C@](O)(C(=O)O)C(=O)c1ccccc1>>CC(C)(C)NC(CO)c1cc(Cl)c(N)c(C#N)c1.O=C(O)[C@](O)(C(=O)c1ccccc1)[C@](O)(C(=O)O)C(=O)c1ccccc1,,CCO,,CCOCC,,val
US05827865,CCOC(=O)C(Cc1ccc(OCCN(C)c2nc3ccccc3o2)cc1)OCC>>CCOC(Cc1ccc(OCCN(C)c2nc3ccccc3o2)cc1)C(=O)O,,CCCCCC,ClCCl,,,val
US20040122218A1,CCOC(=O)C(C#N)c1ncccc1N>>N#Cc1c(O)[nH]c2cccnc12,,[Na+],[OH-],Cc1ccccc1C,,val
US04622334,BrCC1CCCCC1.CC1(C(=O)Cn2cncn2)COCOC1>>CC1(C(=O)C(CC2CCCCC2)n2cncn2)COCOC1,,CS(C)=O,,O,[K+].[OH-],val
US20030220350A1,CCSc1cccc(N)c1.O=C(Cl)OC(Cl)(Cl)Cl>>CCSc1cccc(N=C=O)c1,,Cc1ccccc1,,Cl,,val
US20100009936A1,CC(C)(C)OC(=O)N1C(C)(C)OC[C@]1(C)c1ncc(-c2ccc(OCCCCCc3ccc(C(F)(F)F)cc3)c(C(F)(F)F)c2)s1>>C[C@](N)(CO)c1ncc(-c2ccc(OCCCCCc3ccc(C(F)(F)F)cc3)c(C(F)(F)F)c2)s1,,CC#N,O,,,val
US20100261755A1,CC(C)(C)OC(=O)N1CCC(=O)CC1Cc1ccccc1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>CC(C)(C)OC(=O)N1CCC(C#N)CC1Cc1ccccc1,,COCCOC,,O,CC(C)(C)[O-].[K+],val
US20070232645A1,CCCc1ccc2c(Cl)ccnc2n1.NC(=O)c1cccc(Oc2ccc(Cl)cc2N)c1>>CCCc1ccc2c(Nc3cc(Cl)ccc3Oc3cccc(C(N)=O)c3)ccnc2n1,,CCO,,,,val
US20080096922A1,COC(=O)C(c1cccc(OC)c1)C1CCN(c2ncccn2)CC1>>COc1cccc(C(C(=O)O)C2CCN(c3ncccn3)CC2)c1,,CS(C)=O,O,Cl,[K+].[OH-],val
US04638000,CCO.O=C(O)C(O)CCCCC1CCN(C(=O)OCc2ccccc2)CC1>>CCOC(=O)C(O)CCCCC1CCN(C(=O)OCc2ccccc2)CC1,,CCOC(C)=O,Cc1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050131014A1,COC(=O)c1ccc(CBr)cc1.O=C(c1ccccc1)c1cnc2c(C(F)(F)F)cccc2c1-c1ccc(O)cc1>>O=C(O)c1ccc(COc2ccc(-c3c(C(=O)c4ccccc4)cnc4c(C(F)(F)F)cccc34)cc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160024079A1,COc1cc(C)c2c(ccn2C(=O)OC(C)(C)C)c1C(C)(OC)c1nc2cc(C#N)cnc2n1COCC[Si](C)(C)C>>COc1cc(C)c2[nH]ccc2c1C(C)(OC)c1nc2cc(C#N)cnc2[nH]1,,CCOC(C)=O,O,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20060084652A1,CCO.COc1c(Cl)cccc1C1(CC(=O)C(=O)O)CC1>>CCOC(=O)C(=O)CC1(c2cccc(Cl)c2OC)CC1,,O=C([O-])O,[Na+],O=S(=O)(O)O,,val
US20160108016A1,CC(C)(C(=O)O)c1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(=O)C[C@@H]21>>CC(C)(C(=O)O)c1cc(O)c2c(c1)OC(C)(C)[C@@H]1CC[C@@H](O)C[C@@H]21,,CO,,[BH4-].[Na+],,val
US20140378475A1,CI.Cc1c(Br)cccc1-n1c(=O)[nH]c2c(C)cccc2c1=O>>Cc1c(Br)cccc1-n1c(=O)c2cccc(C)c2n(C)c1=O,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US06538152B1,CC(=O)c1ccc(OCc2ccccc2)c(O)c1.COCCl>>COCOc1cc(C(C)=O)ccc1OCc1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,[Cl-].[NH4+],val
US20040110764A1,CC1(c2ccc(C#N)cc2)CO1.CCOC(=O)c1c[nH]c(S)n1>>CCOC(=O)c1cnc(SCC(C)(O)c2ccc(C#N)cc2)[nH]1,,CCO,,CCN(CC)CC,,val
US20120082702A1,Nc1ccc(C(=O)N2CCOCC2)cc1.O=C(O)c1ccc(Cl)nc1Cl>>O=C(O)c1ccc(Cl)nc1Nc1ccc(C(=O)N2CCOCC2)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20130190287A1,CC(C)(C)OC(N)=O.Clc1nc(Nc2ccccc2)nc(-c2ccccc2)n1>>CC(C)(C)OC(=O)Nc1nc(Nc2ccccc2)nc(-c2ccccc2)n1,,C1COCCO1,,CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1,O=C([O-])[O-].[Cs+].[Cs+],val
US20150141433A1,Cc1nc(C(=O)NCc2cccnc2)ncc1C#N.Cl>>Cl.NCc1cnc(C(=O)NCc2cccnc2)nc1,[Pd],CCO,,,,val
US06069170,CCCCI.COC(=O)C(=CNc1ccc(O)cc1)C(=O)OC>>CCCCOc1ccc(NC=C(C(=O)OC)C(=O)OC)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040204369A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OC[C@H]1CCCNC1>>CC(C)(C)OC(=O)N1CCC[C@H](CO)C1,,ClC(Cl)Cl,,,,val
US20130046108A1,CC(C)O.Cc1ccc(C)c(CCl)c1.[C]=O>>Cc1ccc(C)c(CC(=O)O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,c1ccncc1,Cl,[Na+].[OH-],val
US05025025,CC(C)(C)OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCn1ccnc1>>O=C(O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCn1ccnc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060079572A1,CCOCC(=O)OC(CC)C(C)C1OC1CC(C)/C=C/C=C(\C)C1OC(=O)CC(O[Si](C)(C)C(C)(C)C)CCC(C)(OC(C)OCC)C(OC(C)=O)C=CC1C>>CCOCC(=O)OC(CC)C(C)C1OC1CC(C)/C=C/C=C(\C)C1OC(=O)CC(O)CCC(C)(OC(C)OCC)C(OC(C)=O)C=CC1C,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100075994A1,CC(C)(C)CC(C)(C)c1ccc(OC[C@@H]2CN=C(N)O2)cc1.CCOC(=O)C#CCOC>>COCc1cc(=O)nc2n1C[C@@H](COc1ccc(C(C)(C)CC(C)(C)C)cc1)O2,,ClC(Cl)Cl,,,,val
US20150094297A1,COc1cc(O)c2cc(-c3cn4nc(C)ccc4n3)oc2c1.OCc1csc(C2CCSCC2)n1>>COc1cc(OCc2csc(C3CCSCC3)n2)c2cc(-c3cn4nc(C)ccc4n3)oc2c1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20130310358A1,CCCC[Sn](CCCC)(CCCC)c1ccnc(SC)n1.COc1ccc(Oc2nc(Cl)ncc2NC[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1>>COc1ccc(Oc2nc(-c3ccnc(SC)n3)ncc2NC[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1,,C1COCCO1,CCOC(C)=O,,,val
US20050085458A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=[N+]([O-])c1cc(CC2CCNCC2)ccc1O>>CC(C)(C)OC(=O)N1CCC(Cc2ccc(O)c([N+](=O)[O-])c2)CC1,,C1CCOC1,O,CCN(CC)CC,,val
US05521179,CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)OCCc2cnc(NC(=O)OC(C)(C)C)s2)c1=O)C(=O)C(F)(F)F>>CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)OCCc2cnc(N)s2)c1=O)C(=O)C(F)(F)F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130338137A1,CC1(C)C(=O)Nc2nc(-c3nn(Cc4ccccc4F)c4ncccc34)nc(I)c21.O=S1(=O)CCNCC1>>CC1(C)C(=O)Nc2nc(-c3nn(Cc4ccccc4F)c4ncccc34)nc(N3CCS(=O)(=O)CC3)c21,,CN1CCCC1=O,,,,val
US20100184746A1,Brc1cccnc1.O=Cc1ccc(Br)cc1>>OC(c1ccc(Br)cc1)c1cccnc1,,C1CCOC1,CCOC(C)=O,[Li]CCCC,,val
US20140194469A1,CCC(=O)CC(=O)c1ccc(C)cc1.N#Cc1ccnc(NN)c1>>CCc1cc(-c2ccc(C)cc2)n(-c2cc(C#N)ccn2)n1,,CCO,,CC(=O)O,,val
US20050222171A1,CCOC=O.N#CCc1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1>>N#CC(C=O)c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1,,CCO,,[Na],,val
US20030170174A1,Cc1occc(=O)c1O.NN1CCCCC1>>Cc1c(O)c(=O)ccn1N1CCCCC1,,O,,,,val
US06337331B1,CCn1ncnc1CO.O=c1[nH]c2c(-c3ccccc3F)nnn2cc1C1CCC1>>CCn1ncnc1COc1nc2c(-c3ccccc3F)nnn2cc1C1CCC1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130065905A1,CCCS(=O)(=O)N(COCC[Si](C)(C)C)c1nc2ccccc2nc1OC(c1ccncc1)C(F)(F)F>>CCCS(=O)(=O)Nc1nc2ccccc2nc1OC(c1ccncc1)C(F)(F)F,,O=C(O)C(F)(F)F,,,,val
US20100331293A1,Cc1c(N2CC(C)(C)CC2=O)nc2cc(F)cc(F)c2c1Cl.Nc1cncc(N2CCOCC2)c1>>Cc1c(N2CC(C)(C)CC2=O)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1,,Cc1ccccc1,,,,val
US20020042414A1,CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)C2CN(Cc3ccccc3)CC21>>CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)C2CNCC21,[Pd],CO,,O=C[O-].[NH4+],,val
US20040002524A1,COc1ccc(Nc2ccccc2N)c(C)c1.Cc1noc(C)c1C(=O)O>>COc1ccc(Nc2ccccc2NC(=O)c2c(C)noc2C)c(C)c1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US04311698,CC(=O)N1CC(O)C[C@H]1C(=O)Nc1ccc(-c2ccc(C(=O)O)c(=O)[nH]2)cc1.CC(=O)OC(C)=O>>CC(=O)OC1C[C@@H](C(=O)Nc2ccc(-c3ccc(C(=O)O)c(=O)[nH]3)cc2)N(C(C)=O)C1,,CO,,c1ccncc1,,val
US20080312316A1,CC(C)c1oc2cc(N)ccc2c(=O)c1-c1ccc(Cl)cc1.O=C1CCC(=O)N1Br>>CC(C)c1oc2c(Br)c(N)ccc2c(=O)c1-c1ccc(Cl)cc1,,ClC(Cl)Cl,,,,val
US20090306136A1,O=C(c1ccccc1N1CCOC1=O)N1CCC(N(C2CC2)S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1>>O=C(c1ccccc1NCCO)N1CCC(N(C2CC2)S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1,,O,,[K+].[OH-],,val
US05648368,CC(C)(C)OC(=O)N1CCC(CCN)CC1.O=C(O)c1cccc(S(=O)(=O)Cl)c1>>CC(C)(C)OC(=O)N1CCC(CCNS(=O)(=O)c2cccc(C(=O)O)c2)CC1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US06200254B1,O=C1CCC=CCCCCCCC=CCC1>>O=C1CCCCCCCCCCCCCC1,[Pd],CCO,,[H][H],,val
US05389633,CCC(CC)(CO)CCS(N)(=O)=O.COC(OC)N(C)C>>CCC(CC)(CO)CCS(=O)(=O)N=CN(C)C,,Cc1ccccc1,,,,val
US04536209,CCOC(=O)C(C)Oc1cc(N2C(=O)C3=C(CCCC3)C2=O)ccc1Br>>COC(=O)C(C)Oc1cc(N2C(=O)C3=C(CCCC3)C2=O)ccc1Br,,CO,,,,val
US05302720,CS(=O)(=O)N1CCNCC1.N#CNc1ccccc1-c1ccccc1>>CS(=O)(=O)N1CCN(C(=N)Nc2ccccc2-c2ccccc2)CC1,,CCO,,,,val
US20090047244A1,CC(=O)Cl.CN1CCCCC=C[C@@H]2C[C@@]2(C(=O)O)NC(=O)[C@H](CCO)NC1=O>>CC(=O)CCC1NC(=O)N(C)CCCCC=CC2CC2(C(=O)O)NC1=O,,ClCCl,,CC(=O)O,,val
US20100022484A1,CC(=O)C1=C(C)NC(C)=C(C(=O)O)[C@@H]1c1cccc2c(=O)cc(C)oc12.O=C(n1ccnc1)n1ccnc1>>CC(=O)C1=C(C)NC(C)=C(C(=O)n2ccnc2)[C@@H]1c1cccc2c(=O)cc(C)oc12,,C1CCOC1,,,,val
US20150291655A1,C=C(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@@](CF)(C(=O)OCc7ccccc7)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.O=CCC1(O)COC1>>C=C(C)[C@@H]1CC[C@]2(NCCC3(O)COC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@@](CF)(C(=O)OCc7ccccc7)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,CC(=O)O,CO,O=C([O-])[O-].[Na+].[Na+],,val
US06432993B1,CN(C(=O)OC(C)(C)C)c1cc(Sc2ccccn2)ccc1NC(=O)COc1ccc(CC2SC(=O)NC2=O)cc1>>Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccc(Sc3ccccn3)cc21,,C1COCCO1,Cl,,,val
US20160159747A1,CC(C)(C)OC(=O)CCC(=O)OC(C)(C)C.CC1(C=O)NC=CN1Cc1ccccc1>>Cc1ncc(/C=C(\CC(=O)O)C(=O)OC(C)(C)C)n1Cc1ccccc1,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US05665718,C=CCBr.CN1Cc2c(-c3nc(CN)no3)ncn2-c2cccc(Cl)c2C1=O>>C=CCNCc1noc(-c2ncn3c2CN(C)C(=O)c2c(Cl)cccc2-3)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20160024540A1,C1COCCN1.CC(C)C=CC=O.O=CC(=O)O>>CC(C)=CC1=CC(=O)OC1N1CCOCC1,,O,,,,val
US05547967,CCO.CCOC(=O)CC(C)=O.COc1ccc(C(=O)Cl)cc1OC>>CCOC(=O)C(C(C)=O)(C(C)=O)C(=O)c1ccc(OC)c(OC)c1,,C1CCOC1,CCO,C,C[O-].[Na+],val
US05703106,CCOC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N=C(c1ccccc1)c1ccccc1>>CCOC(=O)[C@@H](N)Cc1ccc(-c2ccno2)cc1,,CC#N,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090298819A1,CC(C)(C)OC(=O)N1CCN(c2ccccc2O)CC1.CCOC(=O)CCCBr>>CCOC(=O)CCCOc1ccccc1N1CCN(C(=O)OC(C)(C)C)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080261919A1,CCC(O)c1ccnc(OC)c1OC>>CCC(=O)c1ccnc(OC)c1OC,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20160218303A1,Cc1cccc(Nc2cc(C#N)ccc2[N+](=O)[O-])c1>>Cc1cccc(Nc2cc(C#N)ccc2N)c1,,CCO,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20120258950A1,CC(C)(C)[Si](C)(C)OCC(O)CO[Si](C)(C)C(C)(C)C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)[Si](C)(C)OCC(CO[Si](C)(C)C(C)(C)C)OS(=O)(=O)C(F)(F)F,,ClCCl,,Cl,c1ccncc1,val
US20140329799A1,CC(C)(C)OC(=O)N1CCC[C@@H](Nc2nc(C3CCNCC3)[nH]c(=O)c2-c2nc3ccccc3s2)C1.COC(=O)Cl>>COC(=O)N1CCC(c2nc(N[C@@H]3CCCN(C(=O)OC(C)(C)C)C3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1,,ClCCl,,CCN(CC)CC,,val
US04233309,CC(=O)OCCn1c(C)ccc1C.O=C(Cl)c1ccc(Cl)cc1>>CC(=O)OCCn1c(C)cc(C(=O)c2ccc(Cl)cc2)c1C,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20120041004A1,Cc1c[nH]c2c(=O)n(C)c(=O)n(C)c12.O=C(CBr)Nc1nc(-c2cc(F)c(OCC3CC3)c(F)c2)cs1>>Cn1c(=O)c2c(ccn2CC(=O)Nc2nc(-c3cc(F)c(OCC4CC4)c(F)c3)cs2)n(C)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20060194837A1,O=Cc1cccc(O)c1.c1ccc(COCC2CO2)cc1>>O=Cc1cccc(OCC(O)COCc2ccccc2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100152155A1,CC(C)(C)OC(=O)N1CC2C(C1)C2NS(=O)(=O)c1ccc2ccccc2c1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=S(=O)(NC1C2CNCC21)c1ccc2ccccc2c1,,ClCCl,,,,val
US20160002224A1,Nc1cc(Cl)c(Br)cc1I.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1cc(Cl)c(Br)cc1I)C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070275952A1,N#Cc1ccccc1N1CCNCC1.O=C=Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>N#Cc1ccccc1N1CCN(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1,,ClCCl,O,CCN(CC)CC,,val
US20080227784A1,COCCOCOc1ccc(Cl)cc1C(=O)Nc1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)c(F)c1.Cl>>Cl.NC1CCN(c2ccc(NC(=O)c3cc(Cl)ccc3O)cc2F)CC1,,CCOC(C)=O,,,,val
US20100273764A1,COc1ncc(Nc2ncc(C(C)=O)nc2-c2cc(SC)nc(C)n2)cc1F.O=C(OO)c1cccc(Cl)c1>>COc1ncc(Nc2ncc(C(C)=O)nc2-c2cc(S(C)=O)nc(C)n2)cc1F,,C1COCCO1,,,,val
US05885986,CCCNCCC.CN1Cc2c(-c3nc(CCl)cs3)ncn2-c2ccccc2C1=O>>CCCN(CCC)Cc1csc(-c2ncn3c2CN(C)C(=O)c2ccccc2-3)n1,,C1CCOC1,,,,val
US06271265B1,CC(C)(C)N.O=C(Cl)c1ccc2ccccc2c1>>CC(C)(C)NC(=O)c1ccc2ccccc2c1,,CCOC(C)=O,,,,val
US20080207900A1,CCOC(=O)[C@@H](CCC(=O)c1cc(F)c(F)c(F)c1)NC(=O)OC(C)(C)C>>CCOC(=O)[C@H]1CCC(c2cc(F)c(F)c(F)c2)=N1,,CCOC(C)=O,,Cl,,val
US20130317031A1,CC1COCC(C)N1CC(=O)NN.O=C(O)/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1>>CC1COCC(C)N1CC(=O)NNC(=O)/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1,,C1CCOC1,O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20120010195A1,CC1CCN(c2c(Cl)nc(S(C)(=O)=O)n2-c2c(F)cc(F)cc2F)CC1>>CC1CCN(c2c(Cl)ncn2-c2c(F)cc(F)cc2F)CC1,,C1CCOC1,,CO,,val
US20150152063A1,COC[C@H](C)NC(=NC(=O)c1ccc(OCc2ccccc2)cc1)Nc1n[nH]c2cc(F)ccc12>>COC[C@H](C)NC(=NC(=O)c1ccc(O)cc1)Nc1n[nH]c2cc(F)ccc12,,CO,,O=C[O-].[NH4+],,val
US20140274907A1,COc1cc2c(cc1OCCCOc1cc3c(cc1OC)C(=O)N1C=C(C)C[C@H]1C(=O)N3COCC[Si](C)(C)C)N(COCC[Si](C)(C)C)C(=O)[C@@H]1CC(/C=C/CNC(=O)OCC3c4ccccc4-c4ccccc43)=CN1C2=O>>COc1cc2c(cc1OCCCOc1cc3c(cc1OC)C(=O)N1C=C(C)C[C@H]1C(=O)N3COCC[Si](C)(C)C)N(COCC[Si](C)(C)C)C(=O)[C@@H]1CC(/C=C/CN)=CN1C2=O,,CN(C)C=O,,C1CCNCC1,,val
US20090163508A1,Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.Fc1ccc(-c2ccnc(N3CCNCC3)n2)cc1>>Cc1noc(NC(=O)N2CCN(c3nccc(-c4ccc(F)cc4)n3)CC2)c1C,,C1CCOC1,CCCCCC,Cl,Cl,val
US20150065715A1,COC1CCN(c2ncc(N)cc2Cl)CC1.O=C(Cl)c1cnn(-c2ccc(Cl)cc2)c1.c1ccncc1>>COC1CCN(c2ncc(NC(=O)c3cnn(-c4ccc(Cl)cc4)c3C)cc2Cl)CC1,,O,c1ccncc1,CCN(CC)CC,[Na+].[OH-],val
US05629325,C#Cc1ccccc1.CN1CCC[C@H]1COc1cncc(Br)c1.ClCCl>>CN1CCC[C@H]1COc1cncc(C#Cc2ccccc2)c1.Cl.Cl,[Cu]I,,,CCN(CC)CC,,val
US20130005705A1,COC(=O)c1c(C)cccc1I.O=C1CCC(=O)N1Br>>COC(=O)c1c(I)cccc1CBr,,ClC(Cl)(Cl)Cl,,,,val
US20100305104A1,C1CCNC1.CCOC(=O)c1ccc(F)c([N+](=O)[O-])c1>>O=C(O)c1ccc(N2CCCC2)c([N+](=O)[O-])c1,,C1CCOC1,CN(C)C=O,O,[Li+].[OH-],val
US20040209920A1,C=C(CO[C@@H]1CCC[C@H](OCc2nc(-c3cccc(C)c3)oc2C)C1)C(=O)OCC.C[S+](C)C>>CCOC(=O)C1(CO[C@@H]2CCC[C@H](OCc3nc(-c4cccc(C)c4)oc3C)C2)CC1,,CS(C)=O,,[H-].[Na+],,val
US04420325,COc1cc(OC)nc(N)n1.CS(=O)(=O)c1ccccc1CS(=O)(=O)N=C=O>>COc1cc(OC)nc(NC(=O)NS(=O)(=O)Cc2ccccc2S(C)(=O)=O)n1,,ClCCl,,,,val
US20060189681A1,CI.O=Cc1cccc(O)c1>>COc1cccc(C=O)c1,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US05656629,N#Cc1c(Cc2ccccc2)nn(C2CCCC2)c1NC(=O)Cc1ccccc1.OO>>O=c1nc(Cc2ccccc2)nc2n(C3CCCC3)[nH]c(Cc3ccccc3)c1-2,,CCO,O,[Na+].[OH-],,val
US20030040437A1,CSC1(C)C(=O)CC(=O)C2CC21>>CC1=CCCC(=O)CC1=O,[Ni],CO,,,,val
US20070197542A1,CS(=O)(=O)Cl.FC(F)(F)COc1ccc(N2CCNCC2)cc1>>CS(=O)(=O)N1CCN(c2ccc(OCC(F)(F)F)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20080032968A1,COC(OC)N(C)C.COc1cc2c(ccn2S(=O)(=O)c2ccccc2)c(CN(C)C)c1O>>COc1cc2c(ccn2S(=O)(=O)c2ccccc2)c(CN(C)C)c1OC,,CN(C)C=O,,,,val
US20070249670A1,CCOC(=O)C[C@H](NC(=O)c1ccc(-c2ccc(OC)cc2)cc1NC(=O)Nc1c(C)cc(C)cc1C)C(=O)OCc1ccccc1>>CCOC(=O)C[C@H](NC(=O)c1ccc(-c2ccc(OC)cc2)cc1NC(=O)Nc1c(C)cc(C)cc1C)C(=O)O,[Pd],CCO,CCOC(C)=O,[H][H],,val
US05994563,CCOP([O-])OCC.O=Cc1csc([N+](=O)[O-])c1>>CCOP(=O)(OCC)C(O)c1csc([N+](=O)[O-])c1,,CO,,,,val
US20140343029A1,Fc1ccc(-c2c[nH]c(C3CCNCC3)n2)cc1C(F)(F)F.O=C(OCc1ccccc1)ON1C(=O)CCC1=O>>O=C(OCc1ccccc1)N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)c[nH]2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20090197866A1,Nc1cn(C2CCCCO2)nc1-c1nc2cc(F)c(N3CCOCC3)cc2[nH]1.O=C(Cl)N1CCCCC1>>O=C(Nc1cn(C2CCCCO2)nc1-c1nc2cc(F)c(N3CCOCC3)cc2[nH]1)N1CCCCC1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20120309751A1,Fc1ccc2c(c1)NCCC2.O=C(O)c1ccc2cccnc2c1O>>O=C(c1ccc2cccnc2c1O)N1CCCc2ccc(F)cc21,,C1CCOC1,,Cl,O=C(n1ccnc1)n1ccnc1,val
US04656165,C=CCOC(=O)NCC(=O)O.O=S(Cl)Cl>>C=CCOC(=O)NCC(=O)Cl,,Cc1ccccc1,,,,val
US05342846,Cl.c1ccc(C(c2ccccc2)N2CC(n3ccnn3)C2)cc1>>Cl.c1cn(C2CNC2)nn1,[Pd],CCO,,,,val
US20090170907A1,C[C@@H](N)c1ccc2ccccc2c1.N#Cc1ccc(F)cc1C(F)(F)F>>C[C@@H](Nc1ccc(C#N)c(C(F)(F)F)c1)c1ccc2ccccc2c1,,CS(C)=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070270414A1,COC(=O)c1cc(S(C)(=O)=O)c(F)cc1C.O=S1(=O)CC(c2ccccc2)CN1>>COC(=O)c1cc(S(C)(=O)=O)c(N2CC(c3ccccc3)CS2(=O)=O)cc1C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],O=C([O-])O.[Na+],val
US20160221972A1,COC(=O)c1ccc2c(c1)OCCN(c1cccnc1)C2.NO>>O=C(NO)c1ccc2c(c1)OCCN(c1cccnc1)C2,,C1CCOC1,CO,[Na+].[OH-],,val
US20100029611A1,Fc1cc(C2OCCCO2)ccc1-c1nc2ccc(C3(c4ccccc4)CC3)nc2s1>>O=Cc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1,,C1CCOC1,,Cl,O,val
US20080293770A1,O=[N+]([O-])c1cc(C(F)F)c(Cl)cc1NC1CCN(C2CCOCC2)CC1>>Nc1cc(C(F)F)c(Cl)cc1NC1CCN(C2CCOCC2)CC1,[Ni],CCO,,NN,O,val
US20100120798A1,Cn1cc(-c2cccc(C3(CNC(=O)CNC(=O)OC(C)(C)C)CCN(C(=O)OC(C)(C)C)CC3)c2)cn1>>Cn1cc(-c2cccc(C3(CNC(=O)CN)CCNCC3)c2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020173490A1,CCN=C=S.COC(=O)CN=C(SC)SC>>CCNc1sc(SC)nc1C(=O)OC,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20130085148A1,CC(=O)c1ccncc1.Fc1ccc(-c2cncs2)cc1>>CC(O)(c1ccncc1)c1ncc(-c2ccc(F)cc2)s1,,C1CCOC1,,[Li]CCCC,,val
US04302398,COC(=O)[C@]1(O)Cc2c(OC)ccc(OC)c2C2(C1)SCCS2>>COc1ccc(OC)c2c1C[C@@](O)(CO)CC21SCCS1,,C1CCOC1,,[BH4-].[Na+],,val
US20110003784A1,CC(C)(C)OC(=O)N1CCN(C(N)=O)CC1.O=C(O)C(F)(F)F>>NC(=O)N1CCNCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20030212074A1,Nc1ccc(Cl)cc1.O=C(O)c1c(O)c(Br)cc(Br)c1O>>O=C(Nc1ccc(Cl)cc1)c1c(O)c(Br)cc(Br)c1O,,Clc1ccccc1,,ClP(Cl)Cl,,val
US05688810,Nc1ccc(Br)cc1Cl.O=[N+]([O-])c1cccc(B(O)O)c1>>Nc1ccc(-c2cccc([N+](=O)[O-])c2)cc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US03943141,Cc1ccc2c(=O)c(C(=O)O)cn(CCO)c2n1.O=CO>>Cc1ccc2c(=O)c(C(=O)O)cn(CCOC=O)c2n1,,c1ccncc1,,CC(=O)OC(C)=O,,val
US20070004736A1,CC(C)(C)OC(=O)N1CCC(n2ccnc2C=O)CC1>>CC(C)(C)OC(=O)N1CCC(n2ccnc2CO)CC1,,CO,,[BH4-].[Na+],,val
US20080081810A1,CC(C)(C)OC(=O)N1CCC(NC(=O)c2ccc(Br)cc2NC2(Cc3cccc(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1>>O=C(NC1CCNCC1)c1ccc(Br)cc1NC1(Cc2cccc(Cl)c2)C(=O)Nc2cc(Cl)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060111375A1,COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1OCCCCCl.OCCC1CCNCC1>>COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1OCCCCN1CCC(CO)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150087585A1,CCO.CNS(=O)(=O)c1cncc(C#N)c1>>CCOC(=N)c1cncc(S(=O)(=O)NC)c1,,CCO,,C,C[O-].[Na+],val
US04698352,Cc1cc(=O)c(C(=O)O)cn1-c1ccc(F)cc1.O=Cc1ccncc1>>O=C(O)c1cn(-c2ccc(F)cc2)c(C=Cc2ccncc2)cc1=O,,O,,CC(=O)OC(C)=O,,val
US20060079567A1,CCOC(=O)N1CC2c3scc(C)c3C(C)C2C1.ClCCl>>CCOC(=O)N1CC2c3sc(Cl)c(C)c3C(C)C2C1,,ClCCl,,ClC(Cl)Cl,,val
US20150232463A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc(C)c(Br)c1N1CCC(C)(C)CC1.Cc1ccc(B(O)O)cc1F>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc(C)c(-c2ccc(C)c(F)c2)c1N1CCC(C)(C)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20130005941A1,CC(N)=S.CCOC(=O)c1sc(C)nc1CBr>>CCOC(=O)c1sc(C)nc1CS,,CCO,,,,val
US20100029710A1,CCc1nc2c(C)cc(C#C[C@H](C)O)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnnn3C(c3ccccc3)(c3ccccc3)c3ccccc3)ccc21.CI>>CCc1nc2c(C)cc(C#C[C@H](C)OC)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnnn3C(c3ccccc3)(c3ccccc3)c3ccccc3)ccc21,,C1CCOC1,,[H-].[Na+],,val
US20140274930A1,CC(=O)OC[C@H]1O[C@H](Oc2ccc(Br)cc2C)[C@@H](F)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.O=[N+]([O-])c1cccc(B(O)O)c1>>Cc1cc(-c2cccc([N+](=O)[O-])c2)ccc1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1F,[Pd],CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070225306A1,Clc1ncc(Br)c(Cl)n1.N>>Nc1nc(Cl)ncc1Br,,C1CCOC1,,,,val
US20090036493A1,O=S(=O)(Cl)Cl.O=[N+]([O-])c1cccc(-c2nccs2)c1>>O=[N+]([O-])c1cccc(-c2ncc(Cl)s2)c1,,ClC(Cl)Cl,,CN(C)C=O,,val
US04550169,CSC1=NCCN1CC(C)O.I.NN>>CC(O)CN1CCN=C1NN.I,,CC(C)O,,O,,val
US20100298340A1,Cc1nc(NC(=N)N)sc1-c1cccc(N)c1.O=Cc1c(O)cccc1Br>>Cc1nc(NC(=N)N)sc1-c1cccc(NCc2c(O)cccc2Br)c1,,CC(=O)O,ClCCl,,,val
US20140065103A1,CC(C)(C)OC(=O)N1CCC(N)CC1.CC1CCC(C(=O)Cl)CC1.COC(=O)c1sc(C#CC(C)C)cc1Br>>COC(=O)c1sc(C#CC(C)C)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C1CCN(C(=O)OC(C)(C)C)CC1,,Cc1ccccc1,,c1ccncc1,,val
US20080207666A1,C1CCNCC1.COC(=O)CC(=O)OC.O=Cc1cc(-c2ccc(Cl)cc2)c(-c2ccccc2Cl)[nH]c1=O>>O=C(c1cc2cc(-c3ccc(Cl)cc3)c(-c3ccccc3Cl)nc2oc1=O)N1CCCCC1,,CCCCCC,CCOC(C)=O,CN(C)C=O,,val
US06447656B1,I.O=C1CCCCCCCCCCCCCCCO1>>O=C(O)CCCCCCCCCCCCCCCI,,CC(=O)O,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20100184739A1,O=[N+]([O-])c1cc(OCc2ccccc2)c(C2CCCCC2)cc1C(F)(F)F>>Nc1cc(OCc2ccccc2)c(C2CCCCC2)cc1C(F)(F)F,Cl[Ni]Cl,CO,,[BH4-].[Na+],,val
US20040229892A1,CNO.N#Cc1ccccc1N1CCOCC1>>CN(O)C(=N)c1ccccc1N1CCOCC1,,CCO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US06303593B1,Fc1ccc(C2CCN(CC3CNCC3c3ccsc3)CC2)cc1.O=C(Cl)c1cccnc1Cl>>O=C(c1cccnc1Cl)N1CC(CN2CCC(c3ccc(F)cc3)CC2)C(c2ccsc2)C1,,ClCCl,,CCN(CC)CC,,val
US04290971,CC(=O)NC(=S)Nc1c(Cl)cccc1Cl.CCCCBr>>CCCCSC(=NC(C)=O)Nc1c(Cl)cccc1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100216810A1,CC(C)(C#N)c1cccc(C(=O)Cl)c1Cl.Nc1cc(O)ccc1F>>CC(C)(C#N)c1cccc(C(=O)Nc2cc(O)ccc2F)c1Cl,,C1CCOC1,O,CCOC(C)=O,O=C([O-])O.[Na+],val
US06140342,CCOC(=O)N(Cc1ccccc1)[C@@H]1C[C@H](C)Nc2cc(OC)c(OC)cc21.O=C(Cl)Cl>>CCOC(=O)N(Cc1ccccc1)[C@@H]1C[C@H](C)N(C(=O)Cl)c2cc(OC)c(OC)cc21,,Cc1ccccc1,,,,val
US04628058,CCCCN(CC1Cc2cc(Cl)cc(Cl)c2O1)C(=O)Cl.c1c[nH]cn1>>CCCCN(CC1Cc2cc(Cl)cc(Cl)c2O1)C(=O)n1ccnc1,,C1CCOC1,,,,val
US20100120741A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(Nc1ccc(Cl)cc1I)c1ccco1>>CC(C)(C)OC(=O)N(C(=O)c1ccco1)c1ccc(Cl)cc1I,CN(C)c1ccncc1,CN(C)C=O,O,,,val
US04737439,N#Cc1ccc(C(=O)Cl)cc1.O=C(c1ccccn1)C(O)c1ccccn1>>N#Cc1ccc(COC(C(=O)c2ccccn2)c2ccccn2)cc1,,CC#N,,ClCCl,c1ccncc1,val
US20120184561A1,CN(C)CCCN(C)c1ccc(N)cc1C(F)(F)F.O=C(O)Cc1ccc(-n2cnc3ccccc32)cc1>>CN(C)CCCN(C)c1ccc(NC(=O)Cc2ccc(-n3cnc4ccccc43)cc2)cc1C(F)(F)F,,CO,ClCCl,,,val
US20070185165A1,CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C.O=C(Nc1ccc(F)c(Cl)c1)c1nonc1CO>>CC(C)[Si](OCc1nonc1C(=O)Nc1ccc(F)c(Cl)c1)(C(C)C)C(C)C,,ClCCl,,Cc1cccc(C)n1,,val
US20030092740A1,Cc1c[nH]cn1.O=[N+]([O-])c1ccc(F)cc1>>Cc1cncn1-c1ccc([N+](=O)[O-])cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110237620A1,CC(C)(C)OC(=O)NC(C(=O)O)c1ccccc1.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)sc3n2)ccc1F>>NC(C(=O)Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)sc3n2)ccc1F)c1ccccc1,,CCOC(C)=O,c1ccncc1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20080004269A1,CCCc1c(I)ncnc1I.CCOC(=O)Cc1ccnn1-c1ncccc1F>>CCCc1c(I)ncnc1C(C(=O)OCC)c1ccnn1-c1ncccc1F,,CS(C)=O,,O,[H-].[Na+],val
US05105020,C#CCOc1cc(F)cc(C2(OC)CCCC2OC)c1.N#CCOc1cccc(I)c1>>COC1CCCC1(OC)c1cc(F)cc(OCC#Cc2cccc(OCC#N)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,C1CCNCC1,,val
US20070281959A1,CC(C)(C)[Si](C)(C)Cl.COc1c(O)ccc2oc(=O)c3c4c(ccc3c12)NC(C)(C)C=C4C>>COc1c(O[Si](C)(C)C(C)(C)C)ccc2oc(=O)c3c4c(ccc3c12)NC(C)(C)C=C4C,,CN(C)C=O,,O,c1c[nH]cn1,val
US20070244159A1,CC(C)(C)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)ccc2n1CC(O)CC#N.[N-]=[N+]=[N-].[NH4+]>>CC(C)(C)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)ccc2n1CC(O)Cc1nn[nH]n1,,CN(C)C=O,,[Cl-].[Na+],,val
US20120238582A1,CCOC(=O)Cc1ccc2c(c1)C(=O)C(=O)N2C(=O)OC(C)(C)C.c1ccc2c(c1)CNC2>>CCOC(=O)Cc1ccc(NC(=O)OC(C)(C)C)c(C(=O)C(=O)N2Cc3ccccc3C2)c1,,C1CCOC1,,,,val
US20100069629A1,CCN1CCN(C(=O)c2ccc(C)c(N)c2)CC1.COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4)cn2)cc1.S=C(Cl)Cl>>CCN1CCN(C(=O)c2ccc(C)c(NC(=S)N3CCc4c(-c5cnc(N)nc5)nc(N5CCOCC5)nc43)c2)CC1,,ClCCl,,c1ccncc1,,val
US20050277645A1,CN(C)C(=O)CCl.O=C1CCc2ccccc21>>CN(C)C(=O)CC1Cc2ccccc2C1=O,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20150353553A1,C[C@@H]1CC[C@@H](Cn2c(C(O)c3ccccc3F)nc3nc(Cl)nc(-c4cncc(Cl)c4)c32)CC1.O=S(Cl)Cl>>C[C@@H]1CC[C@@H](Cn2c(C(Cl)c3ccccc3F)nc3nc(Cl)nc(-c4cncc(Cl)c4)c32)CC1,,ClCCl,,,,val
US20080188528A1,CC(C)c1cccc(CBr)c1.CCOC(=O)c1ccc[nH]c1=O>>CCOC(=O)c1cccn(Cc2cccc(C(C)C)c2)c1=O,,CN(C)C=O,,Cl,[H-].[Na+],val
US04041159,CCCNc1c(S(=O)(=O)NC)cc([N+](=O)[O-])c(CC)c1[N+](=O)[O-].ClSc1ccc(Cl)cc1>>CCCNc1c(S(=O)(=O)N(C)Sc2ccc(Cl)cc2)cc([N+](=O)[O-])c(CC)c1[N+](=O)[O-],,ClCCl,,c1ccncc1,,val
US20150284409A1,CC(C)(OC(=O)Oc1ccccn1)C(F)(F)F.COc1cc2ccnc(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6(C)CC6)C[C@H]5C=CCC[C@@H](C)O[C@@H](C)[C@H](N)C(=O)N4C3)c2cc1F>>COc1cc2ccnc(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6(C)CC6)C[C@H]5C=CCC[C@@H](C)O[C@@H](C)[C@H](NC(=O)OC(C)(C)C(F)(F)F)C(=O)N4C3)c2cc1F,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20050090498A1,CCN(CC)CCCl.O=C1Cc2cccc(O)c2N1>>CCN(CC)CCOc1cccc2c1NC(=O)C2,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130150339A1,COc1cc(C#N)ccc1B(O)O.O=S(=O)(Oc1c(F)c(F)c(F)c(F)c1F)c1ccc2c(Cl)nccc2c1>>COc1cc(C#N)ccc1-c1nccc2cc(S(=O)(=O)Oc3c(F)c(F)c(F)c(F)c3F)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20060135578A1,O=Cc1cn(-c2ccccc2)nc1OCc1ccccc1>>O=Cc1cn(-c2ccccc2)nc1O,[Pd],C1CCOC1,,,,val
US20110124634A1,COCn1ccnc1.O=C(Cl)C(Cl)(Cl)Cl>>COCn1ccnc1C(=O)C(Cl)(Cl)Cl,,ClCCl,,CCN(CC)CC,,val
US20160096827A1,Cc1cc(B2OC(C)(C)C(C)(C)O2)cc(C#N)c1O[C@H]1CCN(C(=O)OC(C)(C)C)C[C@H]1F.Clc1ncnc(Nc2ccc(N3CCN(C4COC4)CC3)cc2)n1>>Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)cc(C#N)c1O[C@H]1CCN(C(=O)OC(C)(C)C)C[C@H]1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,ClCCl,O=C([O-])[O-].[Na+].[Na+],,val
US20140349297A1,O=C(CCO)OCc1ccccc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C(CCOS(=O)(=O)C(F)(F)F)OCc1ccccc1,,ClCCl,,c1ccncc1,,val
US20070219210A1,COC(=O)C(=O)CC(=O)c1ccc(OC)nc1.NNc1cccnc1>>COC(=O)c1cc(-c2ccc(OC)nc2)n(-c2cccnc2)n1,,CO,,CC(=O)O,,val
US20090182135A1,COc1ccc(C(Cl)(c2ccc(OC)cc2)c2ccc(SC)cc2)cc1.O=C(OO)c1cccc(Cl)c1>>COc1ccc(C(Cl)(c2ccc(OC)cc2)c2ccc(S(C)=O)cc2)cc1,,ClCCl,,,,val
US06177474B1,CC(C)=CCCl.Cc1cc(O)cc(O)c1C(=O)CC(C)C>>CC(C)=CCOc1cc(C)c(C(=O)CC(C)C)c(O)c1,,CCCCCC,CCOCC,CO,[H-].[Na+],val
US20050143381A1,CC1Nn2c(nn(Cc3ccc(C(F)(F)F)cc3)c2=O)C(c2ccc(Cl)cc2)=C1c1ccc(Cl)cc1>>Cc1nn2c(=O)n(Cc3ccc(C(F)(F)F)cc3)nc2c(-c2ccc(Cl)cc2)c1-c1ccc(Cl)cc1,,ClCCl,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20150353499A1,BrP(Br)Br.OCc1cccc2c(Br)cccc12>>BrCc1cccc2c(Br)cccc12,,ClCCl,,c1ccncc1,,val
US20080146606A1,NC1CCS(=O)(=O)CC1.O=S(=O)(Cl)c1ccc(Br)cc1>>O=S1(=O)CCC(NS(=O)(=O)c2ccc(Br)cc2)CC1,,Cl,ClCCl,,,val
US04277394,CCOC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)OCc1ccccc1.NN>>C[C@@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NN,,CO,,CCOCC,O,val
US20100311766A1,NC(=S)Nc1cc(Br)nc(Br)c1>>Nc1nc2cc(Br)nc(Br)c2s1,,C1CCOC1,,BrBr,,val
US20090181964A1,BrCc1ccccc1.O=C(O)c1cc(F)cc([N+](=O)[O-])c1>>O=C(OCc1ccccc1)c1cc(F)cc([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US07838521B2,CCOc1cc([C@H]2COCC[C@H]2N[C@H](C)c2ccccc2)ccc1OC>>CCOc1cc([C@H]2COCC[C@H]2N)ccc1OC,[Pd],CO,,Cl,[H][H],val
US06306887B1,C#CC(OCC)OCC.CC(C)CC(C=NO)NC(=O)OCc1ccccc1>>CCOC(OCC)c1cc(C(CC(C)C)NC(=O)OCc2ccccc2)no1,,ClCCl,,,,val
US20080194549A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN=[N+]=[N-])C(C)C)ccc1OC>>COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN)C(C)C)ccc1OC,[Pd],CO,,,,val
US04029594,CCCCCCCBr.O=C(O)c1ccc(O)cc1Cl>>CCCCCCCOc1ccc(C(=O)O)c(Cl)c1,,CCO,O,Cl,[K+].[OH-],val
US05932599,C1CCNC1.CNc1nc(Cl)cc(NS(=O)(=O)c2ccc(N)cc2)n1>>CNc1nc(NS(=O)(=O)c2ccc(N)cc2)cc(N2CCCC2)n1,,CCO,,,,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCCSc4nccn4C)cc2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)CCSc4nccn4C)cc2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20080293767A1,CCOC(=O)c1ccc(C)n(C(C)C)c1=O.O=C1CCC(=O)N1Br>>CCOC(=O)c1cc(Br)c(C)n(C(C)C)c1=O,,CN(C)C=O,,,,val
US20140011800A1,C#Cc1cc2c(N[C@@H]3CN(C(=O)OC(C)(C)C)C[C@@H]3CC)c(C(N)=O)cnn2c1.[N-]=[N+]=Nc1ccccc1>>CC[C@H]1CN(C(=O)OC(C)(C)C)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cn(-c4ccccc4)nn3)cc12,,CN(C)C=O,Cc1ccccc1,,,val
US20080070951A1,CC(C)(C)OC(=O)NNC(=O)c1ccc(O)cc1.O=[N+]([O-])c1ccc(Br)cn1>>CC(C)(C)OC(=O)NNC(=O)c1ccc(Oc2ccc([N+](=O)[O-])nc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090264445A1,CC(C)C[C@@H](C(=O)Nc1ccn(C[C@@H]2COC(C)(C)O2)n1)N1CC(Oc2cccc(CC(C)(C)O)c2)=CC1=O>>CC(C)C[C@@H](C(=O)Nc1ccn(C[C@@H](O)CO)n1)N1CC(Oc2cccc(CC(C)(C)O)c2)=CC1=O,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20080280925A1,CN(CC=O)C(=O)OC(C)(C)C.COc1ccccc1CNC(=O)c1cc(C(F)(F)F)nn1-c1cccc(CN)c1>>COc1ccccc1CNC(=O)c1cc(C(F)(F)F)nn1-c1cccc(CNCCN(C)C(=O)OC(C)(C)C)c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20090298878A1,CC(=O)Cl.N#Cc1cc(CON=C2CCN(S(=O)(=O)c3ccc(N)cc3)CC2)ccc1F>>CC(=O)Nc1ccc(S(=O)(=O)N2CCC(=NOCc3ccc(F)c(C#N)c3)CC2)cc1,,C1CCOC1,,CCN(CC)CC,O,val
US06291457B1,CCOC(=O)CC1CNC1.O=C(Cl)OCc1ccccc1>>CCOC(=O)CC1CN(C(=O)OCc2ccccc2)C1,,O=C([O-])O,[Na+],C1CCOC1,,val
US20120184542A1,COc1ncc2cc(C(=O)Nc3cc(C(=O)N[C@@H](CCNC(=O)OC(C)(C)C)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1>>COc1ncc2cc(C(=O)Nc3cc(C(=O)N[C@@H](CCN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120245144A1,Brc1ccc2c(c1)-c1nc(I)cn1CCO2.Cc1n[nH]cc1B1OC(C)(C)C(C)(C)O1>>Cc1n[nH]cc1-c1cn2c(n1)-c1cc(Br)ccc1OCC2,,C1COCCO1,O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],val
US20030060498A1,Cl.Cn1cc(CCNC(=O)OC(C)(C)C)c2cc(S(=O)(=O)c3ccccc3)ccc21>>Cl.Cn1cc(CCN)c2cc(S(=O)(=O)c3ccccc3)ccc21,,C1COCCO1,,,,val
US04581356,CC(C)CCON=O.CCC(=O)c1ccc2c(c1)CCC(=O)N2CCOCc1ccccc1>>CC(=NO)C(=O)c1ccc2c(c1)CCC(=O)N2CCOCc1ccccc1,,ClCCl,,Cl,,val
US20100317515A1,CSSC.Fc1ccc([C@@]2(Cn3cncn3)O[C@@H]2c2ccccc2Cl)cc1F>>CSc1ncnn1C[C@]1(c2ccc(F)c(F)c2)O[C@@H]1c1ccccc1Cl,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20070197555A1,CCc1c(C)nc(-c2ccccc2O)n(CCc2ccccc2)c1=O.CI>>CCc1c(C)nc(-c2ccccc2OC)n(CCc2ccccc2)c1=O,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20100069368A1,COC(=O)c1nc[nH]c1C(=O)OC.NN>>O=c1[nH][nH]c(=O)c2[nH]cnc12,,CO,,,,val
US20060024775A1,[N-]=[N+]=NCCOCCOCCOCCN1C(=O)c2ccccc2C1=O>>[N-]=[N+]=NCCOCCOCCOCCN,,CO,,NN,O,val
US04267176,CON.Nc1ccnc(C(=O)C(=O)[O-])n1>>CON=C(C(=O)O)c1nccc(N)n1,,CO,,Cl,,val
US20150141406A1,COc1nccc2c1c(=O)[nH]n2C1CCCC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1nccc2c1c(OS(=O)(=O)C(F)(F)F)nn2C1CCCC1,,CC#N,,c1ccncc1,,val
US06777432B1,CCOC(=O)CBr.O=C(Nc1ccc(F)c([N+](=O)[O-])c1)c1ccc(S)nc1>>CCOC(=O)CSc1ccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20150141400A1,CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(CN3CC[C@@H](N)C3)c(C(F)(F)F)cc2c1=O.CN(C)CC(=O)O>>CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(CN3CC[C@@H](NC(=O)CN(C)C)C3)c(C(F)(F)F)cc2c1=O,,CS(C)=O,ClCCl,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US20110172240A1,CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)N[C@@H](CCCCNC(=O)/C=C/C(=O)OC)C(=O)OC(C)(C)C>>CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)N[C@@H](CCCCNC(=O)/C=C/C(=O)OC)C(=O)O,,C1COCCO1,,Cl,,val
US20100029650A1,CSSC.Fc1cc(I)ccc1Br>>CSc1ccc(Br)c(F)c1,[Zn],CN(C)C=O,,CCOCC,Cl,val
US20100048636A1,CCC[C@](OCCN)(c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1.COC(=O)Cl>>CCC[C@](OCCNC(=O)OC)(c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20070270422A1,CS(=O)(=O)OCc1ccc(Oc2ccc([N+](=O)[O-])cc2)nc1.Oc1ccc(C(F)(F)F)cc1>>O=[N+]([O-])c1ccc(Oc2ccc(COc3ccc(C(F)(F)F)cc3)cn2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090023762A1,C/C(=C\C(=O)N(C)C#N)c1cccc(Br)c1.COc1ccc(CN)cc1>>COc1ccc(CN2C(=N)N(C)C(=O)CC2(C)c2cccc(Br)c2)cc1,,CN(C)C=O,,,,val
US05840732,CCCC=O.O=C1CSC(=O)N1CCCCSc1nccc2nccn12>>CCCC=C1SC(=O)N(CCCCSc2nccc3nccn23)C1=O,,CCO,,C1CCNCC1,,val
US20040058903A1,CC(=O)c1cc([N+](=O)[O-])ccc1NCCc1ccccn1>>CC(=O)c1cc(N)ccc1NCCc1ccccn1,[Pd],C1CCOC1,CO,[H][H],,val
US20120115885A1,BrCC1CCOCC1.COc1ccc(Cn2c(=O)c(-c3cccs3)c(O)c3cc(Br)ccc32)cc1>>COc1ccc(Cn2c(=O)c(-c3cccs3)c(OCC3CCOCC3)c3cc(Br)ccc32)cc1,,C1CCOC1,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20120289474A1,CCc1noc(Cn2c(=O)n(C3CCN(C(=O)OC(C)(C)C)CC3)c(=O)c3sc(-c4ccc5c(c4)OCO5)cc32)n1.Cl>>CCc1noc(Cn2c(=O)n(C3CCNCC3)c(=O)c3sc(-c4ccc5c(c4)OCO5)cc32)n1.Cl,,C1COCCO1,,,,val
US06432993B1,CN(C(=O)OC(C)(C)C)c1cc(Oc2ccccc2N2CCOCC2)ccc1N.O=C(O)COc1ccc(CC2SC(=O)NC2=O)cc1>>CN(C(=O)OC(C)(C)C)c1cc(Oc2ccccc2N2CCOCC2)ccc1NC(=O)COc1ccc(CC2SC(=O)NC2=O)cc1,,C1CCOC1,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20160002177A1,COCCOCOc1cc(-c2ccccc2CS(C)(=O)=O)c(Cl)c2c(=O)n(COCCOC)cnc12>>CS(=O)(=O)Cc1ccccc1-c1cc(O)c2nc[nH]c(=O)c2c1Cl,,O,,O=C(O)C(F)(F)F,,val
US06376491B1,CCOC(=O)c1oc2cccc(OCCCNC3CCN(Cc4ccccc4)CC3)c2c1C>>CCOC(=O)c1oc2cccc(OCCCNC3CCNCC3)c2c1C,[Pd],CCOC(C)=O,,CC(=O)O,[H][H],val
US20100216814A1,CC(=CBr)c1cccc(F)c1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>C/C(=C\n1c2c(c3cc(C)ccc31)CN(C)CC2)c1cccc(F)c1,[Cu]I,CN(C)C=O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US05585394,CCOc1ccc2[nH]c(=O)n(C34CC5CC(CC(C5)C3)C4)c2c1.COc1cc([N+](=O)[O-])ccc1S(=O)(=O)Cl>>CCOc1ccc2c(c1)n(C13CC4CC(CC(C4)C1)C3)c(=O)n2S(=O)(=O)c1ccc([N+](=O)[O-])cc1OC,,C1CCOC1,CN(C)C=O,O,[H-].[Na+],val
US04629736,CCCCCCCC(=O)NCC(=O)NCC(=O)O.CCCCCCCCCCCCCCCC(O)CC(=O)OC(C)(C)C>>CCCCCCCCCCCCCCCC(CC(=O)OC(C)(C)C)OC(=O)CNC(=O)CNC(=O)CCCCCCC,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20050043347A1,COc1cc(-c2csc3c(/C=C/CCOC4CCCCO4)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C>>COc1cc(-c2csc3c(/C=C/CCO)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20080167307A1,CCCCCCCN(CCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1)c1ccc([N+](=O)[O-])cc1>>CCCCCCCN(CCc1csc(SC(C)(C)C(=O)O)n1)c1ccc([N+](=O)[O-])cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04771045,COC(=O)CS[C@H]1NC(=O)[C@H]1NC(c1ccccc1)(c1ccccc1)c1ccccc1.N>>NC(=O)CS[C@H]1NC(=O)[C@H]1NC(c1ccccc1)(c1ccccc1)c1ccccc1,,CCO,,,,val
US20090023702A1,N#Cc1ccc(F)c(F)c1.O=c1cc(OCc2ccccc2)cc[nH]1>>N#Cc1ccc(-n2ccc(OCc3ccccc3)cc2=O)c(F)c1,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20080009512A1,CC(C)(C)OC(=O)NC1Cc2ncccc2NC1=O.CI>>CN1C(=O)C(NC(=O)OC(C)(C)C)Cc2ncccc21,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US05658858,COC(=O)Cl.Nc1c(C(=O)O)ccc(Cl)c1Cl>>COC(=O)Nc1c(C(=O)O)ccc(Cl)c1Cl,,C1CCOC1,O,CCN(CC)CC,Cl,val
US20110288097A1,BrCc1ccccc1.CC1(C)CC(=O)NC(=O)C1>>CC1(C)CC(=O)N(Cc2ccccc2)C(=O)C1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110281838A1,C#C[Si](C)(C)C.Cc1nc(N)nc(-c2ccc(S(C)(=O)=O)cc2)c1I>>Cc1nc(N)nc(-c2ccc(S(C)(=O)=O)cc2)c1C#C[Si](C)(C)C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,CCN(CC)CC,,val
US20150031733A1,COC(=O)Cl.Cc1c(N)cccc1Cl>>COC(=O)Nc1cccc(Cl)c1C,,O,,C1CCOC1,,val
US20120149721A1,C[Si](C)(C)CCOCCl.Cc1nc(Cl)c2[nH]c(C)c(Br)c2n1>>Cc1nc(Cl)c2c(n1)c(Br)c(C)n2COCC[Si](C)(C)C,,CN(C)C=O,ClCCl,CS(C)=O,[H-].[Na+],val
US20080261969A1,FC(F)(F)Oc1ccc2nc(S)[nH]c2c1.O=Cc1ccc([N+](=O)[O-])o1>>O=Cc1ccc(Sc2nc3cc(OC(F)(F)F)ccc3[nH]2)o1,,C1CCOC1,,[H-].[Na+],,val
US20050207972A1,CCN(CC)CCNC(=O)c1ccc(N)cc1OC.O=C(Cl)c1ccc2c(c1)OCO2>>CCN(CC)CCNC(=O)c1ccc(NC(=O)c2ccc3c(c2)OCO3)cc1OC,,ClC(Cl)Cl,,,,val
US20040229862A1,COc1ccc(N2CCOCC2)c2sc(-c3nc4c([nH]3)CN(C(=O)OC(C)(C)C)CC4)nc12.Cl>>COc1ccc(N2CCOCC2)c2sc(-c3nc4c([nH]3)CCNC4)nc12.Cl,,CO,,,,val
US20070185324A1,COC(CN)OC.Cc1sc(C=O)cc1Br>>COC(C/N=C/c1cc(Br)c(C)s1)OC,,O,,,,val
US20030153568A1,CCNC(=O)Nc1nc2c(s1)C(=O)C(Br)CC2.NC(=S)Nc1ccc(Br)cc1>>CCNC(=O)Nc1nc2c(s1)-c1nc(Nc3ccc(Br)cc3)sc1CC2,,C1CCOC1,,,,val
US20020006944A1,O=C(c1ccccc1)c1cccc2ccccc12>>OC(c1ccccc1)c1ccc2ccccc2c1,,CO,O,[BH4-].[Na+],,val
US06358971B1,COC(=O)c1ccc(-c2c(NC(=O)C(F)(F)F)nc3ccc(C(=O)c4ccccc4)cn23)cc1>>COC(=O)c1ccc(-c2c(N)nc3ccc(C(=O)c4ccccc4)cn23)cc1,,CCOC(C)=O,,,,val
US20080132509A1,CC1CCCN1c1nc(-c2ccc(F)cc2)cc(-c2ccc(F)nc2)n1.OC1CCNCC1>>CC1CCCN1c1nc(-c2ccc(F)cc2)cc(-c2ccc(N3CCC(O)CC3)nc2)n1,,CC(=O)N(C)C,,,,val
US20090264434A1,COC(=O)C(CC1CCCC1)n1ncc(Oc2ccccc2CCO)cc1=O>>O=C(O)C(CC1CCCC1)n1ncc(Oc2ccccc2CCO)cc1=O,,C1COCCO1,,Cl,,val
US20030149104A1,CCOC(=O)C(Cc1ccc(O)c(C)c1)OCC.CS(=O)(=O)OCCc1ccc(OS(C)(=O)=O)cc1>>CCOC(=O)C(Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)c(C)c1)OCC,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06288096B1,COC(=O)Nc1ccc(CCOS(C)(=O)=O)cc1.O=Cc1ccc(O)cc1>>COC(=O)Nc1ccc(CCOc2ccc(C=O)cc2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120329785A1,CN(C)Cc1ccc(N)cc1.COc1ccc(Cn2cc3c(n2)c(Cl)nc2cc(OC)ccc23)cc1>>COc1ccc2c(c1)nc(Nc1ccc(CN(C)C)cc1)c1n[nH]cc12,C1COCCO1,CO,,Cl,,val
US20160257951A1,CCCCCCCCCCC(=O)CCCCCCC/C=C\C[C@@H](CCCCCC)O[Si](C)(C)C(C)(C)C>>CCCCCCCCCCC(O)CCCCCCC/C=C\C[C@@H](CCCCCC)O[Si](C)(C)C(C)(C)C,,C1CCOC1,CO,[BH4-].[Na+],,val
US05959107,N#Cc1ccc(F)c(Cl)c1.Sc1cccc2cnccc12>>N#Cc1ccc(Sc2cccc3cnccc23)c(Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050049262A1,CC(=O)O[C@H](C)CCCCn1c(=O)c2[nH]c(COCc3ccccc3)nc2n(C)c1=O>>CC(=O)O[C@H](C)CCCCn1c(=O)c2[nH]c(CO)nc2n(C)c1=O,[Pd],CC(=O)O,,[H][H],,val
US20110105553A1,CSC(=S)Nc1ccc(C)cc1C(=O)/C=C(\O)c1ccc(C)cc1>>Cc1ccc(C(=O)c2c(O)c3cc(C)ccc3[nH]c2=S)cc1,,CO,,Cl,C[O-].[Na+],val
US20030055265A1,Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1CC(=O)O>>Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1CCO,,C1CCOC1,,B,,val
US20130345258A1,CI.Cc1cc2nccc(Cl)c2cc1S(=O)(=O)C1CCOCC1>>Cc1cc2nccc(Cl)c2cc1S(=O)(=O)C1(C)CCOCC1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20130303540A1,Cc1cc(OCCCl)nn1-c1ccc2ccccc2c1.O=C1COCCN1>>Cc1cc(OCCN2CCOCC2=O)nn1-c1ccc2ccccc2c1,,CN(C)C=O,,O,[H-].[Na+],val
US04405552,Cc1nc(N)ccc1-c1ccccc1.O=C=NC(=O)c1ccccc1Br>>Cc1nc(NC(=O)NC(=O)c2ccccc2Br)ccc1-c1ccccc1,,CCOC(C)=O,,,,val
US20110117073A1,CC(C)(C)OC(=O)NCCS.CS(=O)(=O)c1nc(Cl)cc(Nc2ncc(C#N)s2)n1>>CC(C)(C)OC(=O)NCCSc1nc(Cl)cc(Nc2ncc(C#N)s2)n1,,C1CCOC1,,CCN(CC)CC,,val
US20100190824A1,CC(=O)C(C)(C)CNCc1cccs1.O=Cc1ccccc1F>>CC1(C)CN(Cc2cccs2)C(c2ccccc2F)CC1=O,,CO,O,Cl,[Na+].[OH-],val
US20050014725A1,CC(C)(C)OC(=O)CCNCc1ccc2sc(-c3ccc(-c4ccccc4)c(C(F)(F)F)c3)c(Cl)c2c1>>O=C(O)CCNCc1ccc2sc(-c3ccc(-c4ccccc4)c(C(F)(F)F)c3)c(Cl)c2c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20060128734A1,CCc1ccc(NC(=O)Nc2ccc(Cc3cc(N)ncn3)cc2)cc1.O=C=Nc1cccc(C(F)(F)F)c1>>Nc1cc(Cc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ncn1,,CN(C)C=O,,,,val
US20020052369A1,O=C1Cc2ccc(-c3ccccc3)cc2N1.O=Cc1cc2cc(OCCN3CCCC3)ccc2[nH]1>>O=C1Nc2cc(-c3ccccc3)ccc2C1=Cc1cc2cc(OCCN3CCCC3)ccc2[nH]1,,CCO,,C1CCNCC1,,val
US04168311,CN(C)C(=O)Cl.Cc1cc(O)c2ccccc2n1>>Cc1cc(OC(=O)N(C)C)c2ccccc2n1,,CN(C)C=O,,,,val
US20100184739A1,O=C([O-])OCc1cc([N+](=O)[O-])c(Br)cc1C1CCCCC1.[OH-]>>O=[N+]([O-])c1cc(O)c(C2CCCCC2)cc1Br,,CO,,Cl,,val
US04782052,CC[C@@]1(C(C)C(=O)OC)CCCN2CCc3c(n(C)c4ccccc34)[C@@H]21>>CC[C@@]1(C(C)C(=O)O)CCCN2CCc3c(n(C)c4ccccc34)[C@@H]21,,CCO,,[K+].[OH-],,val
US20090186900A1,CCc1cc(Br)ccc1OC.COB(OC)OC>>CCc1cc(B(O)O)ccc1OC,,C1CCOC1,ClCCl,CCCCCC,[Li]CCCC,val
US20040254159A1,O=C1Nc2cc(CCO)ccc2NC2=C1CCC(Cl)=C2.O=c1cccc[nH]1>>O=C1Nc2cc(CCOc3ccccn3)ccc2Nc2cc(Cl)ccc21,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110052562A1,CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)O.Nc1ccc(-c2ccncc2)cc1N>>N[C@H](Cc1ccccc1)c1nc2cc(-c3ccncc3)ccc2[nH]1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150259354A1,C=CC(=O)Cl.NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1[nH]c1ccc(N)cc12>>C=CC(=O)Nc1ccc2[nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn3c2c1,,ClCCl,,,,val
US20050148652A1,Nc1cccc(S(F)(F)(F)(F)F)c1.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1c1cccc(S(F)(F)(F)(F)F)c1,,CC(=O)O,,O,,val
US20080167269A1,CC(C)NC(C)C.C[Si](C)(C)CC[Si](C)(C)CCCOCC1CO1>>CC(C)N(CC(O)COCCC[Si](C)(C)CC[Si](C)(C)C)C(C)C,,CCO,,,,val
US20100272678A1,COC(=O)c1cc([N+](=O)[O-])c(C(=O)OC)[se]1>>COC(=O)c1cc(N)c(C(=O)OC)[se]1,[Fe],CO,O,Cl,[Cl-].[NH4+],val
US20040224930A1,COCSC(C)(C)C.O=S(=O)([O-])O[O-]>>COCS(=O)(=O)C(C)(C)C,,CO,,O,,val
US20030065174A1,CCCC(O)CCN(C)C(=O)OC(C)(C)C.O=[N+]([O-])c1ccc(Cl)cc1F>>CCCC(CCN(C)C(=O)OC(C)(C)C)Oc1cc(Cl)ccc1[N+](=O)[O-],,CN(C)C=O,,,,val
US20150344436A1,CC[C@@](C)(NC(=O)OC(C)(C)C)C(=O)O.O=C(c1cc(Cl)c[nH]1)N(Cc1ccc(O)cc1F)CC1CCC1.c1ccncc1>>CC[C@](C)(NC(=O)OC(C)(C)C)C(=O)Oc1ccc(CN(CC2CCC2)C(=O)c2cc(Cl)n[nH]2)c(F)c1,,CCOC(C)=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100035863A1,Nc1nc(Cl)cc(Cl)n1.c1ccc2c(c1)CNC2>>Nc1nc(Cl)cc(N2Cc3ccccc3C2)n1,,CCO,,CCN(CC)CC,,val
US20140275531A1,Cc1cnc(O)c(Br)c1.O=C(O)C(F)(F)S(=O)(=O)F>>Cc1cnc(OC(F)F)c(Br)c1,,CC#N,,O,O=C([O-])[O-].[Na+].[Na+],val
US20160176896A1,CC(C)(C)OC(=O)N1C(=O)c2cc(-c3ccnc(Cl)n3)sc2C1(C)C>>CC1(C)NC(=O)c2cc(-c3ccnc(Cl)n3)sc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US04810720,CC(=O)C(=CN(C)C)SC(F)(F)F.NNc1c(Cl)cc(C(F)(F)F)cc1Cl>>Cc1c(SC(F)(F)F)cnn1-c1c(Cl)cc(C(F)(F)F)cc1Cl,,CCO,,Cl,,val
US20140088079A1,COc1cc(Br)cc(C(=O)O)c1Cl.O=C(Cl)C(=O)Cl>>COc1cc(Br)cc(C(=O)Cl)c1Cl,,ClCCl,,CN(C)C=O,,val
US03982019,Cc1cc(N)ccc1Cl.O=C=NC(F)(F)F>>Cc1cc(NC(=O)NC(F)(F)F)ccc1Cl,,Cc1ccccc1,,,,val
US20120101083A1,CC(C)Oc1ccc(C(=O)Cl)cc1C#N.Cc1c(C(=N)NO)ccc2c1CCN(C(=O)OC(C)(C)C)C2>>Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(=O)OC(C)(C)C)C2,,Cc1ccccc1,c1ccncc1,,,val
US20050245764A1,COC(=O)[C@@H](O)Cc1ccccc1.CS(=O)(=O)Cl>>COC(=O)[C@H](Cc1ccccc1)OS(C)(=O)=O,,Cc1ccccc1,O,CCN(CC)CC,Cl,val
US20040220235A1,O=C(O)Cc1ccc([N+](=O)[O-])cc1.O=Cc1ccc(Cl)c(C(F)(F)F)c1>>O=[N+]([O-])c1ccc(/C=C/c2ccc(Cl)c(C(F)(F)F)c2)cc1,,CC(C)O,,C1CCNCC1,,val
US20050197350A1,CC(C)(C)OC(=O)NC1CCC(CN)C1.O=C(Cl)c1cccnc1Cl>>CC(C)(C)OC(=O)NC1CCC(CNC(=O)c2cccnc2Cl)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04021557,CN(C)CCCl.CN1C(=O)c2cccnc2Nc2ccccc21>>CN(C)CCN1c2ccccc2N(C)C(=O)c2cccnc21,,Cc1ccccc1C,O,CCOCC,[H-].[Na+],val
US20050250811A1,CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CC=CC(O)C1.CS(=O)(=O)Cl>>CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CC=CC(OS(C)(=O)=O)C1,CN(C)c1ccncc1,ClCCl,,Cl,,val
US04994486,COc1ccc2c(c1OCc1ccccc1)C[C@@H](c1ccccc1)O[C@H]2CN.Cl>>COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN.Cl,[Pd],CCOC(C)=O,CO,,,val
US20080255202A1,CCOC(=O)c1cnc(Br)s1.Oc1cccc(Cl)c1>>CCOC(=O)c1cnc(Oc2cccc(Cl)c2)s1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110178089A1,Fc1ccc2c(c1)CCCN2.O=C(O)c1cncnc1Oc1cc(Cl)ccc1Cl>>O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2cc(F)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140155413A1,CC(C)(C)Oc1ccc(O)cc1.CC(C)(C)[Si](C)(C)OCCO>>CC(C)(C)Oc1ccc(OCCO[Si](C)(C)C(C)(C)C)cc1,,Cc1ccccc1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070293694A1,COC(=O)C[C@@H](CC(N)=O)CC(C)C>>CC(C)C[C@H](CC(N)=O)CC(=O)O,,Cl,,,,val
US20130310384A1,C[C@@H](O)[C@H](N)CO.O=S(=O)(Cl)c1ccc(Cl)cc1>>C[C@@H](O)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)cc1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20090023746A1,CN(C)CCCO.Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(Cc3ccc(Br)nc3)ccc2c1>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(Cc3ccc(OCCCN(C)C)nc3)ccc2c1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20090050843A1,COC=C1CCC(C(=O)OC)CC1>>COC(=O)C1CCC(C=O)CC1,,C1CCOC1,Cl,CCCCCC,,val
US20030187023A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.O=S(=O)(C[C@@H]1CCCN1)c1ccc2cc(Cl)ccc2c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N1CCC(NC(=O)N2CCC[C@H]2CS(=O)(=O)c2ccc3cc(Cl)ccc3c2)CC1,,Cc1ccccc1,,CCN(CC)CC,,val
US04808597,COC(=O)c1ccc(/C=C(\C)c2ccc3c(c2)C(C)(C)CCO3)cc1>>C/C(=C\c1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCO2,,CCO,,[K+].[OH-],,val
US20090111789A1,CCOc1nc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1.O=C(Cl)Cl>>CCOc1nc(C(C)(C)C)ncc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1C(=O)Cl,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US20160046631A1,CC(C)(C)N.Fc1nc(N2CCC(F)(F)C2)c2nc[nH]c2n1>>CC(C)(C)Nc1nc(N2CCC(F)(F)C2)c2nc[nH]c2n1,,CC(C)(C)O,,,,val
US20100113774A1,COc1cc(OC)c(NC(=O)Cn2c(=O)n(CCNC(=O)OC(C)(C)C)c(=O)c3ccccc32)cc1Cl.O=C(O)C(F)(F)F>>COc1cc(OC)c(NC(=O)Cn2c(=O)n(CCN)c(=O)c3ccccc32)cc1Cl.O=C(O)C(F)(F)F,,ClCCl,,CCOC(C)=O,,val
US20120053166A1,C1COCCN1.Cc1ccc(S(=O)(=O)n2ncc3c(-c4nnc(CCl)o4)cc(-c4cnc(Cl)c(NS(C)(=O)=O)c4)cc32)cc1>>Cc1ccc(S(=O)(=O)n2ncc3c(-c4nnc(CN5CCOCC5)o4)cc(-c4cnc(Cl)c(NS(C)(=O)=O)c4)cc32)cc1,,CC#N,,,,val
US20050171358A1,NCc1cc(-c2ccccc2)no1.O=C=NC1CCCCC1>>O=C(NCc1cc(-c2ccccc2)no1)NC1CCCCC1,,CCO,,,,val
US05025031,COC(=O)c1ccc(O)cc1.O=C=NS(=O)(=O)Cl>>COC(=O)c1ccc(OS(N)(=O)=O)cc1,,C1CCOC1,,Cc1ccccc1,O,val
US20140349990A1,CCOC(=O)c1c(C(O)c2ccc(Cl)cc2)c(C)nn1-c1cnc(OC)nc1OC.Cn1cc(N)cc(Cl)c1=O>>CCOC(=O)c1c(C(Nc2cc(Cl)c(=O)n(C)c2)c2ccc(Cl)cc2)c(C)nn1-c1cnc(OC)nc1OC,,CCOC(C)=O,,,,val
US20040209886A1,CCOC(=O)CBr.NN1C(=O)c2ccccc2C1=O>>CCOC(=O)CNN1C(=O)c2ccccc2C1=O,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20070105890A1,Cn1c(=O)c2c(nc(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)n2Cc2cc(F)ccc2Cl)c2ccc(C(N)=O)cc21>>Cn1c(=O)c2c(nc(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)n2Cc2cc(F)ccc2Cl)c2ccc(C#N)cc21,,C1CCOC1,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20030114469A1,COC(=O)Cc1cncc2ccc(C#C[Si](C)(C)C)cc12>>C#Cc1ccc2cncc(CC(=O)OC)c2c1,,CO,,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US20060035908A1,CC(C)(C)OC(=O)NCCn1cnc(N)c1.O=C=Nc1cccc(C(F)(F)F)c1>>CC(C)(C)OC(=O)NCCn1cnc(NC(=O)Nc2cccc(C(F)(F)F)c2)c1,,ClCCl,,,,val
US20090054648A1,CC1(N)CN(Cc2ccccc2)CC12CC2.O=C(O)[C@H](O)c1ccccc1>>CC1(N)CN(Cc2ccccc2)CC12CC2.O=C(O)[C@H](O)c1ccccc1,,Cc1ccccc1,,,,val
US20050288321A1,Cc1ccc([N+](=O)[O-])c(CO)c1>>Cc1ccc([N+](=O)[O-])c(C=O)c1,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20140213586A1,COc1cccc(N)c1.O=Cc1cn2cc(F)ccc2n1>>COc1cccc(N=Cc2cn3cc(F)ccc3n2)c1,,CCO,,,,val
US20040014784A1,C#Cc1ccccc1.C1CCNCC1.C=O>>C(#Cc1ccccc1)CN1CCCCC1,Cl[Cu],C1COCCO1,,Cl,,val
US20040229900A1,CCCC1(CCCBr)OCCO1.c1ccc(CN2CC3CNCC(C3)C2)cc1>>CCCC1(CCCN2CC3CC(C2)CN(Cc2ccccc2)C3)OCCO1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05484551,C/C=C/C(=O)O.O=Cc1ccc(O)cc1>>C/C=C/C(=O)Oc1ccc(C=O)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130245021A1,CC1(C)OB(C2=CCCC2)OC1(C)C.CCOc1ccccc1CCNc1ccc2ncc(Br)n2n1>>CCOc1ccccc1CCNc1ccc2ncc(C3=CCCC3)n2n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20100137299A1,FC(F)(F)c1cccnc1CCl.O=C1Nc2cccc(F)c2C12COc1cc3c(cc12)OCCO3>>O=C1N(Cc2ncccc2C(F)(F)F)c2cccc(F)c2C12COc1cc3c(cc12)OCCO3,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20080255083A1,BrCc1ccoc1.O=c1cc(O)ccn1CCc1ccc(CO)cc1>>O=c1cc(OCc2ccoc2)ccn1CCc1ccc(CO)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110257137A1,CN1CCN(c2nc(CN)c3cc(Cl)ccc3n2)CC1.O=CO>>CN1CCN(c2nc(CNC=O)c3cc(Cl)ccc3n2)CC1,,ClCCl,,CC(=O)OC(C)=O,,val
US20110039843A1,CC(C)I.Oc1cnccc1-c1nc2cc(C(F)(F)F)cnc2o1>>CC(C)Oc1cnccc1-c1nc2cc(C(F)(F)F)cnc2o1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US03941803,NN.Nc1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1>>NN=C(c1ccccc1)c1cc([N+](=O)[O-])ccc1N,,OCCOCCO,,O,,val
US20150284358A1,CCOC(=O)c1c(C)nc(-c2cncc(F)c2)n1Cc1cccc2ccccc12>>Cc1nc(-c2cncc(F)c2)n(Cc2cccc3ccccc23)c1C(=O)O,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20010021714A1,CC(=O)OC(C)=O.OCC1(c2cccs2)C=CC=CC1>>CC(=O)OCC1(c2cccs2)C=CC=CC1,,c1ccncc1,,O,,val
US20130053409A1,COc1cc(N2CC(N(C)C)C2)c([N+](=O)[O-])cc1Nc1nccc(-c2c[nH]c3ccccc23)n1>>COc1cc(N2CC(N(C)C)C2)c(N)cc1Nc1nccc(-c2c[nH]c3ccccc23)n1,[Fe],CCO,,O,[Cl-].[NH4+],val
US20130289033A1,O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccccc1I.OB(O)c1ccc(Cl)cc1>>O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccccc1-c1ccc(Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20020047103A1,CCC[C@@H]1CC[C@@H]([C@@H]2CC[C@@H](CCl)CC2)CC1.CO[Si](OC)(OC)OC>>CCC[C@@H]1CC[C@@H]([C@@H]2CC[C@@H](C[Si](OC)(OC)OC)CC2)CC1,,C1CCOC1,,[Mg],,val
US06018046,ClCc1cccnc1.O=c1c(Cc2cccnc2)cn2c3cc(Br)ccc3c3cc(O)cc1c32>>O=c1c(Cc2cccnc2)cn2c3cc(Br)ccc3c3cc(OCc4cccnc4)cc1c32,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130317218A1,CC(=O)Nc1ccc(C(=O)O)cc1.NC(=O)c1nc(Nc2cccc3ccccc23)sc1N>>CC(=O)Nc1ccc(C(=O)Nc2sc(Nc3cccc4ccccc34)nc2C(N)=O)cc1,,C1CCOC1,c1ccncc1,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20100310512A1,CC(C)(C)OC(=O)N1CCCC1C(=O)OCC(=O)c1ccc2c(c1)COCc1cc(Br)ccc1-2.CCCC[Sn](C=COCC)(CCCC)CCCC.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCCC1C(=O)OCC(=O)c1ccc2c(c1)COCc1cc(C(=O)CBr)ccc1-2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O,,val
US20090062539A1,CNc1nc(-c2cccc(NC(=O)c3ccc(C(=O)O)c(C)c3)c2)c2cc(OC)c(OC)cc2n1.O>>CNc1nc(-c2cccc(NC(=O)c3ccc(C(=O)O)c(C)c3)c2)c2cc(OC)c(OC)cc2n1.O,,O,,,,val
US20040082572A1,CI.O=C(NC1N=C(c2ccc(Br)cc2)c2ccccc2NC1=O)OCc1ccccc1>>CN1C(=O)C(NC(=O)OCc2ccccc2)N=C(c2ccc(Br)cc2)c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US04684639,O=C(NC(O)C(=O)O)OCc1ccccc1.Oc1ccc(Cl)cc1O>>O=C(O)CN(C(=O)OCc1ccccc1)c1cc(O)c(O)cc1Cl,,CC(=O)O,CCOC(C)=O,O=S(=O)(O)O,O=C([O-])[O-].[Na+].[Na+],val
US20090124802A1,Cc1cc(C)c(Oc2nc(Nc3ccc(C#N)cc3)nc3ccn(C)c23)c(C)c1.O=C1CCC(=O)N1Cl>>Cc1cc(C)c(Oc2nc(Nc3ccc(C#N)cc3)nc3c(Cl)cn(C)c23)c(C)c1,,ClCCl,,,,val
US20070129347A1,CN(C)C1(c2ccccn2)CCC(CC(=O)NCCCc2ccccc2)CC1.C[Si](C)(C)Cl>>CN(C)C1(c2ccccn2)CCC(CC(=O)NCCCc2ccccc2)CC1.Cl,,CCC(C)=O,,,,val
US20100010035A1,CC(C)OB(OC(C)C)OC(C)C.COCCOCN(c1noc(C)c1C)S(=O)(=O)c1ccc(C)s1>>COCCOCN(c1noc(C)c1C)S(=O)(=O)c1sc(C)cc1B(O)O,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20080176833A1,C1COCCN1.COC(=O)c1ccc2[nH]nc(C=O)c2c1>>COC(=O)c1ccc2[nH]nc(CN3CCOCC3)c2c1,,ClCCl,,CC(=O)O,,val
US20150018363A1,Cc1c(C2CC2)nc2ccc(-n3ccc(O)cc3=O)cn12.OCc1ccc(Br)cc1>>Cc1c(C2CC2)nc2ccc(-n3ccc(OCc4ccc(Br)cc4)cc3=O)cn12,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100292236A1,COc1nn(-c2ncccn2)cc1C(=O)O.NCC12CC3CC(CC(C3)C1)C2>>COc1nn(-c2ncccn2)cc1C(=O)NCC12CC3CC(CC(C3)C1)C2,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20080015203A1,COCc1csc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O[C@@H](C)CO[Si](C)(C)C(C)(C)C)c2)n1>>COCc1csc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O[C@@H](C)CO)c2)n1,,ClCCl,O,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20110130409A1,CCOC(=O)CC1CCc2c1[nH]c1ccc(O)cc21.N#Cc1cc(CO)cc(OC(F)(F)F)c1>>CCOC(=O)CC1CCc2c1[nH]c1ccc(OCc3cc(C#N)cc(OC(F)(F)F)c3)cc21,,C1CCOC1,O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120184544A1,COC(=O)c1cc(Oc2ccc(-c3nnc(C)o3)cc2)cc(O[C@@H]2CCN(C)C2=O)c1>>Cc1nnc(-c2ccc(Oc3cc(O[C@@H]4CCN(C)C4=O)cc(C(=O)O)c3)cc2)o1,,CO,O,[Na+].[OH-],,val
US20050026990A1,N[C@H]1CC(=O)N(OCc2ccccc2)C1=O.O=S(=O)(Cl)N1CCN(c2ccc(C(F)(F)F)cc2)CC1>>O=C1C[C@H](NS(=O)(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)C(=O)N1OCc1ccccc1,CN(C)c1ccncc1,CN(C)C=O,,CCN(CC)CC,Cl,val
US20040259910A1,BrCCCBr.CCOc1cccc(Cc2ncc(C=O)c3cc(O)c(OC)cc23)c1>>CCOc1cccc(Cc2ncc(C=O)c3cc(OCCCBr)c(OC)cc23)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US07049312B1,O=C1Nc2ccccc2OC1=Cc1ccc([N+](=O)[O-])cc1>>Nc1ccc(C=C2Oc3ccccc3NC2=O)cc1,[Ni],CCO,,NN,O,val
US20150252022A1,O=C(Cl)c1ccccc1.c1cc2c(ccn2CC2CCNC2)cc1-c1cnn(C2CCCCO2)c1>>O=C(c1ccccc1)N1CCC(Cn2ccc3cc(-c4cnn(C5CCCCO5)c4)ccc32)C1,,ClCCl,,CCN(CC)CC,CO,val
US04436726,CC(C)(C)OC(=O)CBr.CCCCCCCCCCCCCCCC=O>>CCCCCCCCCCCCCCCC(O)CC(=O)OC(C)(C)C,[Zn],,,,,val
US20060211709A1,O=C(Cc1ccccc1)Nc1cccc(Br)c1>>Brc1cccc(NCCc2ccccc2)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US04879296,Cn1c(N)cc(=O)[nH]c1=O.N#Cc1ccc(CBr)cc1>>Cn1c(N)cc(=O)n(Cc2ccc(C#N)cc2)c1=O,,CCO,,[Na+].[OH-],,val
US05710166,N#Cc1ccc(C=O)cc1.Nc1cccc(C(=O)O)c1>>N#Cc1ccc(CNc2cccc(C(=O)O)c2)cc1,,CN(C)C=O,,CC(=O)O,[BH3-]C#N.[Na+],val
US04143039,CC1(C)S[C@@H]2C(NC(=O)C(N)c3ccccc3)C(=O)N2C1c1nnn[nH]1.O=C(O)CBr>>CC1(C)S[C@@H]2C(NC(=O)C(NC(=O)CBr)c3ccccc3)C(=O)N2C1c1nnn[nH]1,,O,,CCN=C=NCCCN(C)C,Cl,val
US05556864,CC(C)(C)OC(=O)N1C[C@H](O)CC1COc1ccccc1CCc1ccccc1>>CN1C[C@H](O)CC1COc1ccccc1CCc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04623647,CCOc1cc2c(cc1OCC)C(C(CO)CO)NCC2.O=Cc1ccccc1>>CCOc1cc2c(cc1OCC)C1C(CO)COC(c3ccccc3)N1CC2,,c1ccccc1,,CC(=O)O,Cl,val
US05260316,COc1ccc2c(c1)C(O)N(CCCc1ccccc1)C2=O>>COc1ccc2c(c1)CN(CCCc1ccccc1)C2=O,,CCO,Cl,,,val
US20090253669A1,N#CC1(c2cccnc2)CCN(Cc2ccccc2)CC1.O>>NC(=O)C1(c2cccnc2)CCN(Cc2ccccc2)CC1,,CCO,,[K+].[OH-],,val
US20140107094A1,C1CNC1.Cn1cncc1C(O)(c1ccc(C(F)(F)F)nc1)c1ccc2nc(Cl)c(Cc3ccc(C(F)(F)F)cc3)c(Cl)c2c1>>Cn1cncc1C(O)(c1ccc(C(F)(F)F)nc1)c1ccc2nc(N3CCC3)c(Cc3ccc(C(F)(F)F)cc3)c(Cl)c2c1,,CCOC(C)=O,,CN(C)C=O,,val
US05534535,CC(=O)OC[C@@H]1C[C@H](n2c(Br)nc3cc(Cl)c(Cl)cc32)[C@@H](OC(C)=O)[C@H]1OC(C)=O.CC(C)N>>CC(C)Nc1nc2cc(Cl)c(Cl)cc2n1[C@H]1C[C@@H](CO)[C@H](O)[C@@H]1O,,CCO,,,,val
US20080009507A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccnc(Cl)c1>>CC(C)(C)OC(=O)N1C=CC(N)=CC1Cl,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20140323501A1,CC(=O)CCC(=O)Cl.CCOC(=O)C(CCc1ccc(Oc2ccccc2)cc1)(NC(C)=O)C(=O)OCC>>CCOC(=O)C(CCc1ccc(Oc2ccc(C(=O)CCC(C)=O)cc2)cc1)(NC(C)=O)C(=O)OCC,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20140364432A1,C[C@@H]1CCCN[C@@H]1CN1C(=O)c2ccccc2C1=O.O=C(O)c1ccc(F)cc1I>>C[C@@H]1CCCN(C(=O)c2ccc(F)cc2I)[C@@H]1CN1C(=O)c2ccccc2C1=O,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030130270A1,Brc1ccc2cnccc2c1.Cl.O=C(OO)c1cccc(Cl)c1>>Cl.[O-][n+]1ccc2cc(Br)ccc2c1,,CO,ClCCl,CCOCC,,val
US20040259923A1,CCOC(=O)c1nc(NC(C)=O)sc1Cc1ccccc1>>CC(=O)Nc1nc(C=O)c(Cc2ccccc2)s1,,C1CCOC1,,[BH4-].[Li+],,val
US06797726B1,CCN(CC)CCOCCc1ccc2sc(C(=O)O)cc2c1.N>>CCN(CC)CCOCCc1ccc2sc(C(N)=O)cc2c1,,C1CCOC1,,CCOC(C)=O,,val
US04977162,O=C(Cl)C(=O)Cl.O=C(O)c1ccc(OCc2ccc3ccccc3n2)cc1>>O=C(Cl)c1ccc(OCc2ccc3ccccc3n2)cc1,CN(C)C=O,ClCCl,,,,val
US20160002241A1,C=CC(=O)Nc1cccc(Nc2nc(Cl)ncc2[N+](=O)[O-])c1.COCCOc1ccc(N)cc1>>C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCOC)cc3)ncc2[N+](=O)[O-])c1,,CCCCO,,Cl,,val
US20110003787A1,COC[C@H](C)Oc1cc(O[Si](C(C)C)(C(C)C)C(C)C)cc(-c2ccc(C3=N[C@H](C)CO3)[nH]2)c1>>COC[C@H](C)Oc1cc(O)cc(-c2ccc(C3=N[C@H](C)CO3)[nH]2)c1,,C1CCOC1,,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US04148998,CC(=O)OCC1=C(C(=O)O)N2C(=O)C(N)C2SC1.O=C(O)CCCn1cccc1>>CC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)CCCn3cccc3)C2SC1,,C1CCOC1,O,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20070155727A1,CCCCC(C(=O)OCC)N(C)CCCN(C)CC(=O)Nc1ccc(Oc2ccccc2)cc1>>CCCCC(C(=O)O)N(C)CCCN(C)CC(=O)Nc1ccc(Oc2ccccc2)cc1,,CO,,[Na+].[OH-],,val
US20110300165A1,N#Cc1ccc(CO)c(F)c1.NO>>N/C(=N\O)c1ccc(CO)c(F)c1,,CO,,Cl,O=C([O-])O.[Na+],val
US04547514,CN(C)CCN.Cl.NC(=O)N1CCC(Oc2ccc(Cl)c(Cl)c2)C1>>CN(C)CCNC(=O)N1CCC(Oc2ccc(Cl)c(Cl)c2)C1.Cl,,C1CCOC1,,,,val
US20120029190A1,Brc1ccccn1.c1ccc(-c2nc3c(o2)CNCC3)cc1>>c1ccc(-c2nc3c(o2)CN(c2ccccn2)CC3)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20160240783A1,Brc1ccc(Nc2ccc(Br)cc2)cc1.OB(O)c1ccccc1>>Brc1ccc(Nc2ccc(-c3ccccc3)cc2)cc1,,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20160194316A1,CC(=O)O.CC=O.Cc1c(N[C@@H]2COC[C@H]2O)cc(Cl)cc1C(=O)[O-]>>CCN(c1cc(Cl)cc(C(=O)OC)c1C)[C@@H]1COC[C@H]1O,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110152245A1,CC(C)(C)OC(=O)N1CCC(CCc2ccc(N)cc2)C1.Nc1ccc(Cl)cn1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1CCC(CCc2ccc(NC(=O)Nc3ccc(Cl)cn3)cc2)C1,,CC(Cl)Cl,,CCN(CC)CC,,val
US03950528,CCOC(=O)C=C(N)OCC.NNCc1ccc(I)cc1>>Nc1cc(=O)n(Cc2ccc(I)cc2)[nH]1,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120184553A1,CC(C)(C)OC(=O)N1CCC[C@@H]1COS(=O)(=O)c1ccc(Cl)cc1.O=C(Nc1cccnc1)c1cc(O)ccc1OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccc(OCc2ccccc2)c(C(=O)Nc2cccnc2)c1,,CS(C)=O,,O,[H-].[Na+],val
US20130310379A1,Cc1nc(Cl)ccc1C(N)=O.Oc1ccccc1>>Cc1nc(Oc2ccccc2)ccc1C(N)=O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04806145,C=CCO.COC(=O)C(C)Oc1cc(-n2nc(C)n(C(F)F)c2=O)c(Cl)cc1Cl>>C=CCOC(=O)C(C)Oc1cc(-n2nc(C)n(C(F)F)c2=O)c(Cl)cc1Cl,,CCOCC,,C[O-].[Na+],,val
US20040067933A1,CCCCC1(CC)CN(c2ccccc2)c2ccc(OCC(=O)OCC)cc2S(=O)(=O)C1>>CCCCC1(CC)CN(c2ccccc2)c2ccc(OCC(=O)O)cc2S(=O)(=O)C1,,CCO,,CC(=O)O,[Na+].[OH-],val
US20110015157A1,Br[Mg]c1ccccc1.CC(=O)CCN(C(=O)OC(C)(C)C)[C@@H](C)c1ccccc1>>C[C@@H](c1ccccc1)N(CCC(C)(O)c1ccccc1)C(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20160193218A1,COc1cc(N)c(C(N)=O)c(OC)c1.O=Cc1ccccc1F>>COc1cc(OC)c2c(=O)[nH]c(-c3ccccc3F)nc2c1,,CC(=O)N(C)C,,O=S([O-])O.[Na+],,val
US20090192203A1,COC(=O)COc1cc(C2CC2)c(O)cc1C.ClCc1nc(-c2ccc(-c3ccccc3)cc2)cs1>>COC(=O)COc1cc(C2CC2)c(OCc2nc(-c3ccc(-c4ccccc4)cc3)cs2)cc1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110275622A1,CC(C)(C)OC(=O)Oc1ccc([C@H](CN(CCCCCCOCCCCc2ccc([N+](=O)[O-])cc2)C(=O)OC(C)(C)C)O[Si](C)(C)C(C)(C)C)c2ccc(=O)[nH]c12>>CC(C)(C)OC(=O)Oc1ccc([C@H](CN(CCCCCCOCCCCc2ccc(N)cc2)C(=O)OC(C)(C)C)O[Si](C)(C)C(C)(C)C)c2ccc(=O)[nH]c12,[Pd],CO,,[H][H],,val
US20080064720A1,COC(=O)C(N)Cc1ccc([N+](=O)[O-])cc1.Clc1cccc(Cl)c1CBr>>COC(=O)C(Cc1ccc([N+](=O)[O-])cc1)NCc1c(Cl)cccc1Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04179298,O=C1N(Br)CC1(CBr)CBr>>O=C1NCC1(CBr)CBr,,ClC(Cl)(Cl)Cl,,Cc1ccccc1,,val
US20100286173A1,Cc1ccc(C(=O)c2nnnn2C)cc1C(F)(F)F.NO>>Cc1ccc(C(=NO)c2nnnn2C)cc1C(F)(F)F,,c1ccncc1,,Cl,,val
US20140179672A1,COC(=O)[C@H](CNC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cc(C)cn12)NC(=O)OC(C)(C)C>>COC(=O)[C@@H](N)CNC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cc(C)cn12,,CCOCC,,Cl,,val
US20100099681A1,COC(=O)c1ccccc1Nc1c(-c2cc(F)c3nccnc3c2)c(C)nn1-c1cc(F)ccc1F>>Cc1nn(-c2cc(F)ccc2F)c(Nc2ccccc2C(=O)O)c1-c1cc(F)c2nccnc2c1,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20080306110A1,N[C@@H](CO)c1ccccc1.O=C(Cl)OCc1ccccc1>>O=C(N[C@@H](CO)c1ccccc1)OCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20140371201A1,O=c1ccc2cc(S(=O)(=O)Nc3ccon3)ccc2n1-c1ccc(Cl)cc1.OB(O)c1cccc(C(F)(F)F)c1>>O=c1ccc2cc(S(=O)(=O)Nc3ccon3)ccc2n1-c1ccc(-c2cccc(C(F)(F)F)c2)cc1,,C1COCCO1,O,COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20060211717A1,CC(O)c1cccc(Br)c1.COc1cc2ncnc(Oc3ccc(N)c(Cl)c3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)OC(C)c4cccc(Br)c4)c(Cl)c3)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US20060089344A1,N.O=C1COC(=O)N1CCC1CCN(c2ccc3ccccc3n2)CC1>>NC(=O)COC(=O)NCCC1CCN(c2ccc3ccccc3n2)CC1,,CO,,,,val
US20080161289A1,CC(C)(C)OC(=O)N1CCC(c2nc3c(s2)CCN(C2CCC2)CC3)C1>>C1CC(N2CCc3nc(C4CCNC4)sc3CC2)C1,,CO,ClCCl,O=C(O)C(F)(F)F,,val
US04912241,CCC#CBr.CCCCOC(=O)C=Cc1ccc(O)cc1>>C#CCOc1ccc(C=CC(=O)OCCCC)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05135937,N#Cc1ccc(Cc2nc[nH]n2)cc1.O=C1C2CC3CC(C2)CC1C3>>N#Cc1ccc(C(c2nc[nH]n2)C2(O)C3CC4CC(C3)CC2C4)cc1,,C1CCOC1,,O,CC(C)[N-]C(C)C.[Li+],val
US05527819,O=C1CCC(=O)N1Cl.Sc1ccccc1>>O=C1CCC(=O)N1Sc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20140219995A1,CC(Oc1ccc(Cl)cc1Cl)C(=O)O.OCCc1ccc(F)cc1>>CC(Oc1ccc(Cl)cc1Cl)C(=O)OCCc1ccc(F)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050026976A1,CC(=O)Cl.Cc1cccc(NC(=O)Nc2ccc(-c3ccc(N)c4c3CNC4=O)cc2)c1>>CC(=O)Nc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c1C(=O)NC2,,C1CCOC1,,,,val
US05550134,CI.C[C@]12C=CC(=O)N[C@@H]1CCc1cc(-c3cccc4ccccc34)ccc12>>CN1C(=O)C=C[C@]2(C)c3ccc(-c4cccc5ccccc45)cc3CC[C@@H]12,,CCOC(C)=O,,CC(C)(C)O,CC(C)(C)[O-].[K+],val
US20120101039A1,COC(=O)c1cc(CCCN[C@H](C)c2cccc3ccccc23)ccc1O>>C[C@@H](NCCCc1ccc(O)c(C(=O)O)c1)c1cccc2ccccc12,,CO,O,Cl,[Li+].[OH-],val
US06582351B1,N#Cc1cnc(N[C@@H]2CC[C@@H](O)CC2)c(N)c1.O=C(n1ccnc1)n1ccnc1>>N#Cc1cnc2c(c1)[nH]c(=O)n2[C@@H]1CC[C@@H](O)CC1,,CC#N,,Cl,[Na+].[OH-],val
US05739345,O=C1SC(Cc2ccc(O)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1.OCCc1cn2ccccc2n1>>O=C1SC(Cc2ccc(OCCc3cn4ccccc4n3)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1,,c1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20080262036A1,CCCCC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)nc1C.CCOP(=O)(Cc1ccc(C#N)c(F)c1)OCC>>CCCC/C(=C\c1ccc(C#N)c(F)c1)c1sc(-c2ccc(C(F)(F)F)cc2)nc1C,,C1CCOC1,,[H-].[Na+],,val
US20100113462A1,CCOC(=O)C1(N)Cc2ccccc2C1.O=C(O)c1ccnc2ccccc12>>CCOC(=O)C1(NC(=O)c2ccnc3ccccc23)Cc2ccccc2C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070213330A1,COC(=O)c1ccc(CBr)cc1.COc1ccc(-c2ccnc(S)n2)cc1>>COC(=O)c1ccc(CSc2nccc(-c3ccc(OC)cc3)n2)cc1,,CN(C)C=O,,,,val
US20110021500A1,FC(F)(F)CNc1ccccc1.O=C(Cl)c1cc(Cl)ncn1>>O=C(c1cc(Cl)ncn1)N(CC(F)(F)F)c1ccccc1,,CCO,ClCCl,[Na+].[OH-],,val
US20150152112A1,C[Mg]Br.N#Cc1ccc(O)cn1.O=S(=O)(O)O>>CC(=O)c1ccc(O)cn1,,C1CCOC1,Cc1ccccc1,[Na+].[OH-],[Cl-].[NH4+],val
US20100273782A1,CN(C)C1CCNCC1.N#Cc1ccc(Sc2cc(Cl)ccc2Cl)c(S(=O)(=O)Cl)c1>>CN(C)C1CCN(S(=O)(=O)c2cc(C#N)ccc2Sc2cc(Cl)ccc2Cl)CC1,,ClCCl,,CCOC(C)=O,O,val
US20140288043A1,CCOC(=O)c1cc(-c2nn(Cc3ccc(OC)cc3)c3ccnc(NC(C)C)c23)ncn1.CO.COc1ccc(Cn2nc(-c3cc(C(=O)O)ncn3)c3c(NC(C)C)nccc32)cc1>>CC(C)Nc1nccc2[nH]nc(-c3cc(C(=O)N(C)C)ncn3)c12,,CO,,[Li+].[OH-],,val
US20060069286A1,COC(=O)C(NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(O)c1ccc(Cl)c(Cl)c1.ClCCl>>COC(=O)C(=Cc1ccc(Cl)c(Cl)c1)NC(=O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nsnc12,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US04405357,CC(C)(CCl)C(=O)Cl.NO>>CC(C)(CCl)C(=O)NO,,O,,Cl,[Na+].[OH-],val
US05458796,C=C(C)C.CC(C)(Cl)c1ccccc1.CCCCCC.CCl.CO>>CC(C)(C)c1cc(C(C)(C)C)cc(C(C)(C)Cl)c1,,CO,,ClB(Cl)Cl,,val
US20030087936A1,BrCCCCCCOc1nc2ccccc2s1.O=C1NCCN1c1cccnc1>>O=C1N(CCCCCCOc2nc3ccccc3s2)CCN1c1cccnc1,,CN(C)C=O,,[H-].[Na+],,val
US20020012977A1,CC(=O)OCCOc1noc(N(C(=O)OCC(C)C)S(=O)(=O)c2ccc(C(C)(C)C)cc2)c1I.OB(O)c1ccc2c(c1)OCO2>>CC(C)(C)c1ccc(S(=O)(=O)Nc2onc(OCCO)c2-c2ccc3c(c2)OCO3)cc1,,C1COCCO1,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20040063768A1,Cc1ccc(S(=O)(=O)n2cc(CC3CCCC3=O)c3cc(C#N)ccc32)cc1>>N#Cc1ccc2[nH]cc(C=C3CCCC3=O)c2c1,,C1CCOC1,CCOC(C)=O,O,[Na+].[OH-],val
US04548947,COC(=O)CC(c1ccc(Cl)cc1)C1CCC(=O)N1.COC(=O)CCC1NC(=O)CC1c1ccc(Cl)cc1>>O=C(O)CC(c1ccc(Cl)cc1)C1CCC(=O)N1.O=C(O)CCC1NC(=O)CC1c1ccc(Cl)cc1,,[Na+],[OH-],Cl,,val
US20090054407A1,CCCC[Sn](CCCC)(CCCC)c1cccs1.Nc1ccc(Br)c2c1C(=O)NC2>>Nc1ccc(-c2cccs2)c2c1C(=O)NC2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,,,val
US20100298302A1,O=P(Cl)(Cl)Cl.O=c1[nH]c2c(-c3nnc[nH]3)cccc2n2cccc12>>Clc1nc2c(-c3nnc[nH]3)cccc2n2cccc12,,CO,O,CC#N,CCN(CC)CC,val
US20100105700A1,CN(C)C(=O)CCl.C[C@]12CC[C@H]3[C@@H](CC=C4NC(=O)CC[C@@]43C)[C@@H]1CCC2=O>>CN(C)C(=O)CN1C(=O)CC[C@@]2(C)C1=CC[C@H]1[C@@H]3CCC(=O)[C@@]3(C)CC[C@@H]12,,CN(C)C=O,,[H-].[Na+],,val
US20020147192A1,O=C(NCc1ccc(CCO)cc1)c1c(Cl)cncc1Cl>>O=CCc1ccc(CNC(=O)c2c(Cl)cncc2Cl)cc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20120142717A1,CC(=O)Cl.N.N#CCCc1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1>>Cl.N=C(N)CCc1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1,,CO,Cc1ccccc1,,,val
US20080051395A1,Cc1ncoc1-c1cccc(N)c1.O=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Cl)n2)c1)c1c(F)cccc1F>>NC1Cc2ccc(Nc3nccc(-c4c(-c5cccc(NC(=O)c6c(F)cccc6F)c5)nn5ccccc45)n3)cc2C1,,CC(C)O,,Cl,,val
US05143928,CC(=C1SC(=S)NC1=O)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1.CI>>CSC1=NC(=O)C(=C(C)c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)S1,,CCO,,CCN(C(C)C)C(C)C,O,val
US20100305133A1,CCOC(=O)CNC(=O)c1c(O)c(Br)cc2nc(-c3nccs3)cnc12>>O=C(O)CNC(=O)c1c(O)c(Br)cc2nc(-c3nccs3)cnc12,,CCO,,[Na+].[OH-],,val
US20070082912A1,BrCc1ccccc1.CCOC(=O)c1cncc(-n2c(C)ccc2-c2cc(Cl)ccc2O)c1>>CCOC(=O)c1cncc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccccc2)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20080064689A1,CC(C)(C)OC(=O)NCC1CC(c2ccc(Br)cn2)=NO1.CC1(C)OB(c2ccc(N3C[C@H](Cn4ccnn4)OC3=O)cc2F)OC1(C)C>>CC(C)(C)OC(=O)NC[C@@H]1CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cn2)=NO1,c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd-4]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100179109A1,CC(=O)OC(C)=O.CCc1cccc(-c2c(Cl)cccc2C(O)(CCCN)[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)c1>>CCc1cccc(-c2c(Cl)cccc2C(O)(CCCNC(C)=O)[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)c1,,ClCCl,,CCN(CC)CC,,val
US20040127574A1,CC(C)(C)OC(=O)N1C(=O)OC(c2ccc(F)cc2)C1Cc1cccc(S(=O)(=O)C(F)(F)F)c1>>CC(C)(C)OC(=O)NC(Cc1cccc(S(=O)(=O)C(F)(F)F)c1)C(O)c1ccc(F)cc1,,CO,,O,[Na+].[OH-],val
US04420630,O=C(Cl)c1ccc(CCBr)cc1.O=S(=O)(Nc1ccccc1)c1ccc(O)cc1>>O=C(Oc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1ccc(CCBr)cc1,,ClCCl,,CCN(CC)CC,,val
US20040023974A1,COC(=O)CN(c1ccc(OC)cc1OC)S(=O)(=O)NC(=O)OC(C)(C)C>>COC(=O)CN(c1ccc(OC)cc1OC)S(N)(=O)=O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20050143381A1,O=C(CCl)Nc1ccc(C(F)(F)F)cc1.O=c1[nH]nc2c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)cnn12>>O=C(Cn1nc2c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)cnn2c1=O)Nc1ccc(C(F)(F)F)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20040116466A1,COC(=O)c1cnc(N)c(N)c1.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>COC(=O)c1cnc(N)c(NC(=O)c2ccc([N+](=O)[O-])cc2)c1,,c1ccncc1,,O,,val
US04956368,O=C1CC2(CCCC2)C(O)C(=O)N1CCCCN1CCN(c2nsc3ccccc23)CC1>>O=C1CC2(CCCC2)C(C(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)O1,,CC#N,,,,val
US05233035,COc1ccc(COC(=O)C2=C(CCl)CS[C@@H]3C(N)C(=O)N23)cc1.Sc1cnns1>>COc1ccc(COC(=O)C2=C(CSc3cnns3)CS[C@@H]3C(N)C(=O)N23)cc1,,CO,ClCCl,[Na],,val
US20100216798A1,C[Mg]Br.O=C1CCC(Nc2ccc3ncc(-c4ccncc4)n3n2)CC1>>CC1(O)CCC(Nc2ccc3ncc(-c4ccncc4)n3n2)CC1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20030225266A1,CC(C)S(=O)(=O)Cl.C[C@@H](CN)Oc1ccc(Br)cc1>>CC(C)S(=O)(=O)NC[C@H](C)Oc1ccc(Br)cc1,,ClCCl,,CCN(CC)CC,,val
US20130245000A1,CCOC(=O)Cl.Nc1ccc2[nH]ccc2c1>>CCOC(=O)Nc1ccc2[nH]ccc2c1,,ClCCl,,CCN(CC)CC,,val
US05057614,Cn1cccc1C1=C(c2cn(C)c3ccccc23)C(=O)OC1=O.N>>Cn1cccc1C1=C(c2cn(C)c3ccccc23)C(=O)NC1=O,,N,,CN(C)C=O,,val
US20050182052A1,CCN(CC)S(F)(F)F.[N-]=[N+]=NC[C@H]1CN(Cc2ccccc2)C[C@@H]1O>>[N-]=[N+]=NC[C@H]1CN(Cc2ccccc2)C[C@@H]1F,,ClCCl,,O=C([O-])O.[Na+],,val
US20160137629A1,CC(C)(C)OC(=O)N1CCC(CCC(=O)N2CCC[C@@H](C(=O)NC(CC(=O)O)c3cncc(-c4ccc(OCCF)cc4)c3)C2)CC1>>O=C(O)C[C@H](NC(=O)[C@@H]1CCCN(C(=O)CCC2CCNCC2)C1)c1cncc(-c2ccc(OCCF)cc2)c1,,C1COCCO1,,Cl,,val
US20060229286A1,CC(C)(C)C(=O)Cl.O=C(OCc1ccccc1)c1ccc2[nH]ccc2c1>>CC(C)(C)C(=O)n1ccc2cc(C(=O)OCc3ccccc3)ccc21,,CN(C)C=O,,O,[H-].[Na+],val
US05134155,CC(=O)OCC(=O)C1CCCCC1=O.NNc1ccc(F)cc1>>CC(=O)OCc1c2c(nn1-c1ccc(F)cc1)CCCC2,,CCO,,CCN(CC)CC,Cl,val
US20080039437A1,CCOC(=O)c1cc(C#N)c(Cl)nc1C(F)(F)F.O=C(O)C1CCNCC1>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1C(F)(F)F,,CCO,,,,val
US20120094958A1,CC(=O)OC(C)=O.CCOP(=O)(/C=C/c1ccc2cc(N)cc(-c3cccc4ccccc34)c2n1)OCC>>CCOP(=O)(/C=C/c1ccc2cc(NC(C)=O)cc(-c3cccc4ccccc34)c2n1)OCC,,ClCCl,,c1ccncc1,,val
US05387747,BrCc1ccc(Br)cc1.CO>>COC(Br)c1ccccc1,,CO,,[Na],C[O-].[Na+],val
US05677302,CC(=O)c1nsc2nc3ccccc3n12>>CC(O)c1nsc2nc3ccccc3n12,,CO,,O,[BH4-].[Na+],val
US20120316161A1,CC(C)c1nc(C#N)c(N)n1C.Cc1ccc([Mg]Br)cc1.[OH-]>>Cc1ccc(C(=O)c2nc(C(C)C)n(C)c2N)cc1,,C1CCOC1,,Cl,,val
US20040106635A1,CCCCOC(=O)Cl.CCCn1ncc2c(N3CCN(C(=O)C4CCC5(c6cc(OC)c(OC)cc6CCN5C(=O)CCNC)C(C5c6cc(OC)c(OC)cc6CCN5CC)C4)CC3)ncnc21>>CCCCOC(=O)N(C)CCC(=O)N1CCc2cc(OC)c(OC)cc2C12CCC(C(=O)N1CCN(c3ncnc4c3cnn4CCC)CC1)CC2C1c2cc(OC)c(OC)cc2CCN1CC,,ClCCl,,CCN(CC)CC,,val
US05089504,CCC(=O)c1cnc2c(O)cccc2c1Nc1ccc(F)cc1C.OCCBr>>CCC(=O)c1cnc2c(OCCO)cccc2c1Nc1ccc(F)cc1C,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040082579A1,CCCCCCCC(=O)CC(=O)OCC.Nc1ccccc1>>CCCCCCCC(=CC(=O)OCC)Nc1ccccc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US07160887B1,CCOC(=O)CCCBr.C[C@H](NC(=O)OC(C)(C)C)c1cccc(Oc2cc(Cl)ccc2N)c1>>CCOC(=O)CCCNc1ccc(Cl)cc1Oc1cccc([C@H](C)NC(=O)OC(C)(C)C)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130029962A1,CN(CCO)c1ccc(NC(=O)Oc2ccccc2)cn1.NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1>>CN(CCO)c1ccc(NC(=O)NCc2cc(C(F)(F)F)nn2-c2cccc(Cl)c2)cn1,,ClCCl,,CCN(CC)CC,Cl,val
US20050197350A1,Cc1cc(N[C@@H]2CC[C@H](CN)CC2)nc2ccccc12.Cl.O=C(Cl)c1ccc(F)c(F)c1>>Cc1cc(N[C@@H]2CC[C@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc2ccccc12.Cl,,CCOC(C)=O,ClC(Cl)Cl,CCN(C(C)C)C(C)C,,val
US20120184562A1,COC(=O)c1cc2ccc(N3CCN(C)CC3)nc2[nH]c1=O>>CN1CCN(c2ccc3cc(C(=O)O)c(=O)[nH]c3n2)CC1,,CO,O,ClCCl,[Na+].[OH-],val
US20150329497A1,CC1CN(c2ccccc2)CCN1C(=O)OC(C)(C)C.Cl>>CC1CN(c2ccccc2)CCN1.Cl,,C1COCCO1,,,,val
US20040176377A1,CCOC(=O)c1cc(-c2ccc(OCc3ccccc3)cc2)n[nH]c1=O.NN>>CCOC(=O)c1cc(-c2ccccn2)n[nH]c1=O,,CCO,,Cl,Cl,val
US20150133510A1,COC(=O)c1cccc(C=O)c1.NCc1ccccc1>>COC(=O)c1ccc(CNCc2ccccc2)cc1,,CO,,[BH3-]C#N.[Na+],,val
US20150335632A1,C[Mg]Cl.O=Cc1c(NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc2onc(C3CC3)c2c1Cl>>CC(O)c1c(NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc2onc(C3CC3)c2c1Cl,,C1CCOC1,,,,val
US20090298871A1,FC(F)(F)c1ccc(-c2ccc3c(c2)CCN3)cc1.N#Cc1ccc(S(=O)(=O)Cl)cc1>>N#Cc1ccc(S(=O)(=O)N2CCc3cc(-c4ccc(C(F)(F)F)cc4)ccc32)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20120245161A1,CC(C)(C)[SiH2]OC(C)(C)c1ccc(C(F)(F)F)c(C2=CCN(C(=O)OCc3ccccc3)CC2)c1>>O=C(OCc1ccccc1)N1CC=C(c2cc(CO)ccc2C(F)(F)F)CC1,,ClCCl,,CCOCC,FB(F)F,val
US20040162422A1,C#C[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O.CCNS(=O)(=O)CCN>>C#C[C@H]1O[C@@H](n2cnc3c(NCCS(=O)(=O)NCC)ncnc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US04318915,CO.COC(=O)C(Br)c1c(Cl)cccc1Cl>>COC(C(=O)O)c1c(Cl)cccc1Cl,,CO,,C[O-].[Na+],,val
US20090156642A1,Cc1ccccc1-c1ccc(C=O)o1.O=C1CCC(=O)N1Br>>Cc1ccccc1-c1oc(C=O)cc1Br,,CC#N,,,,val
US20150057238A1,CCOC(=O)[C@@]1(C)C[C@@H]1COCc1ccccc1>>CCOC(=O)[C@@]1(C)C[C@@H]1CO,[Pd],CCO,,,,val
US20160052888A1,COC(=O)C1CC(=O)c2cc([C@H]3CC[C@]4(COC(=O)N4)C3)ccc2C1>>COC(=O)C1CCc2cc([C@H]3CC[C@]4(COC(=O)N4)C3)ccc2C1,[Pd],CC(=O)O,,CO,,val
US20110124634A1,CCOC(=O)Cc1c(Cl)nc(N)nc1C(F)(F)F.COc1c(C)cnc(CN)c1C>>COc1c(C)cnc(CN2C(=O)Cc3c2nc(N)nc3C(F)(F)F)c1C,,CC(C)(C)O,,CCN(C(C)C)C(C)C,,val
US20070066618A1,CCc1nc2c(C)cc(Cl)nc2n1-c1ccc(CCN=[N+]=[N-])cc1>>CCc1nc2c(C)cc(Cl)nc2n1-c1ccc(CCN)cc1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140315912A1,C=C[Mg]Br.CON(C)C(=O)Cc1ccc/c(=N\C(=O)OCc2ccccc2)n1C(=O)OCc1ccccc1>>C=CC(=O)Cc1cccc(NC(=O)OCc2ccccc2)n1,,C1CCOC1,,,,val
US04943585,BrP(Br)Br.OCCCOc1ccc(Oc2ccccc2)cc1>>BrCCCOc1ccc(Oc2ccccc2)cc1,,ClC(Cl)(Cl)Cl,,,,val
US20070244131A1,COc1ccc(B(O)O)cn1.CSc1nc(Cl)cc(Cl)n1>>COc1ccc(-c2cc(Cl)nc(SC)n2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05714489,CC(=O)O.CCC(CC)Cn1c(=O)c(=O)[nH]c2cc([N+](=O)[O-])c(N)cc21.COC1CCC(OC)O1>>CCC(CC)Cn1c(=O)c(=O)[nH]c2cc([N+](=O)[O-])c(-n3cccc3)cc21,,CC(=O)O,,,,val
US20040077669A1,CC#CC(C)O.Fc1cccc(-c2cc(Cl)ncn2)c1>>CC#CC(C)Oc1cc(-c2cccc(F)c2)ncn1,,CN(C)C=O,,O,[H-].[Na+],val
US04661596,CCS(=O)(=O)Cl.Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1>>CCS(=O)(=O)Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1,,C1CCOC1,,CCN(CC)CC,,val
US05633276,CCOC(CBr)OCC.Nc1cccc2c1CCO2>>CCOC(CNc1cccc2c1CCO2)OCC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070276000A1,COc1ccc(C(=O)N(C)OC)c(C#CCC(C)C)c1.Cl[Mg]Cc1ccccc1>>COc1ccc(C(=O)Cc2ccccc2)c(C#CCC(C)C)c1,,C1CCOC1,,,,val
US20100093740A1,CC(C)c1nc(I)c2n1CCN(C(=O)OC(C)(C)C)C2CCc1ccc(C(F)(F)F)cc1>>CC(C)c1ncc2n1CCN(C(=O)OC(C)(C)C)C2CCc1ccc(C(F)(F)F)cc1,,C1CCOC1,CCOCC,O,[Li]CCCC,val
US07067540B2,CC(=O)OCC(=O)Cl.Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1cc(NC(=O)OC(C)(C)C)ccc1F>>CC(=O)OCC(=O)Nc1ccc(F)c(-n2c(C)cc(OCc3ccc(F)cc3F)c(Br)c2=O)c1,,C1CCOC1,,CCN(CC)CC,[Cl-].[NH4+],val
US20130005707A1,CC(=O)c1ccc(Br)cc1O.NO>>C/C(=N\O)c1ccc(Br)cc1O,,O,,Cl,CC(=O)[O-].[Na+],val
US04435406,CC1(C)Oc2cc3nc(S)[nH]c3cc2O1.ClCc1ccccn1>>CC1(C)Oc2cc3nc(SCc4ccccn4)[nH]c3cc2O1,,O,,Cl,[Na+].[OH-],val
US05128465,NOCF.Nc1nc(C(=O)C(=O)O)ns1>>Nc1nc(/C(=N/OCF)C(=O)O)ns1,,CCO,O,[Na+].[OH-],,val
US20100249198A1,C[C@@H](C(=O)O)c1ccc(Nc2nc(C(F)(F)F)cs2)cc1.N>>C[C@@H](C(N)=O)c1ccc(Nc2nc(C(F)(F)F)cs2)cc1,,ClCCl,,,,val
US20070060569A1,CCCC[SnH2]c1ccco1.FC(F)(F)c1ccc(Br)cc1>>FC(F)(F)c1ccc(-c2ccco2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20110306589A1,C=C1CC(=O)O1.ClCl.NC1CC1.O=N[O-]>>O=C(NC1CC1)C(Cl)=NO,,ClCCl,O,Cl,,val
US20130345419A1,CC1(C)CC(C)(C)CC(O)(C(F)(F)C(=O)O)C1.COc1ccc(OCc2cnc([C@@H]3CCCN3)o2)cc1OC>>COc1ccc(OCc2cnc([C@@H]3CCCN3C(=O)C(F)(F)C3(O)CC(C)(C)CC(C)(C)C3)o2)cc1OC,,C1CCOC1,O,CCN(CC)CC,CCOC(=O)Cl,val
US05420275,CCOC(=O)c1c(-n2ccnc2)nc(-c2ccccc2)c(N)c1C(=O)OCC.NN>>Nc1c(-c2ccccc2)nc(-n2ccnc2)c2c(=O)[nH][nH]c(=O)c12,,CCO,,O,,val
US20120184520A1,CC1(C)OB(c2cnc(N3CCCCC3)nc2)OC1(C)C.CN(Cc1cccc(Br)c1)C(=O)CNC(=O)OC(C)(C)C>>CN(Cc1cccc(-c2cnc(N3CCCCC3)nc2)c1)C(=O)CN,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClC(Cl)Cl,O,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20160009726A1,C=C(C)c1csc2ccc(C(=O)Nc3cnccc3N3C[C@@H](NC(=O)OC(C)(C)C)C[C@@H](C)C3)nc12>>CC(C)c1csc2ccc(C(=O)Nc3cnccc3N3C[C@@H](NC(=O)OC(C)(C)C)C[C@@H](C)C3)nc12,[Pd],CO,,,,val
US20160158207A1,Cn1cc(-c2ccc3c(c2)CCCN3c2nn([C@H]3CCOC3)c3c2CN(C(=O)OC(C)(C)C)CC3)cn1>>Cn1cc(-c2ccc3c(c2)CCCN3c2nn([C@H]3CCOC3)c3c2CNCC3)cn1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20090239854A1,Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C(=O)OCC(Cl)(Cl)Cl)C1>>Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCNC1,[Zn],CC(=O)O,,O=C([O-])O.[Na+],,val
US20070043081A1,Cc1cc(NC(=O)Nc2cc(C)nc(C)c2)cc(C)n1.NCCN1CCC(Cc2ccccc2)CC1>>Cc1cc(NC(=O)NCCN2CCC(Cc3ccccc3)CC2)cc(C)n1,,C1COCCO1,,,,val
US20140296537A1,COCOc1cc(I)ccc1C(=O)OC.Cc1cc2[nH]cc(C#N)c2s1>>COCOc1cc(-n2cc(C#N)c3sc(C)cc32)ccc1C(=O)OC,[Cu]I,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US04260757,C(=Cc1cnc(C=Cc2ccccc2)cn1)c1ccccc1.O=S([O-])O>>O=Cc1cnc(C=O)cn1,,CO,,O,,val
US20120053166A1,Cc1ccc(S(=O)(=O)n2ncc3c(-c4nnc(C)o4)cc(-c4cnc(Cl)c(NS(C)(=O)=O)c4)cc32)cc1>>Cc1nnc(-c2cc(-c3cnc(Cl)c(NS(C)(=O)=O)c3)cc3[nH]ncc23)o1,,CC(C)O,,[Na+].[OH-],,val
US20100249139A1,CI.Cn1cc(C(=O)Cc2ccc(Br)cc2Cl)ccc1=O>>CC(C(=O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1Cl,,C1CCOC1,,[H-].[Na+],,val
US20070213345A1,CCOC(=O)C(C)C(=O)c1ccco1.CN1C(C)(C)CC(NC(=O)c2ccc(NN)cc2)CC1(C)C>>Cc1c(-c2ccco2)[nH]n(-c2ccc(C(=O)NC3CC(C)(C)N(C)C(C)(C)C3)cc2)c1=O,,CC(=O)O,,,,val
US20050197350A1,Cc1cnc(Cl)nc1N(C)C.Cl.N[C@@H]1CC[C@H](NC(=O)c2ccc(F)c(Cl)c2)CC1>>Cc1cnc(N[C@@H]2CC[C@H](NC(=O)c3ccc(F)c(Cl)c3)CC2)nc1N(C)C.Cl,,CCCCO,CCOC(C)=O,O=C([O-])O.[Na+],,val
US20030134853A1,COc1ccc(-c2ccc(Cl)cc2)c(CBr)c1.N#Cc1ccc2c(c1)nc(-c1ccc(O)cc1)n2C1CCCCC1>>COc1ccc(-c2ccc(Cl)cc2)c(COc2ccc(-c3nc4cc(C#N)ccc4n3C3CCCCC3)cc2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04293702,CO.Clc1cccc2sc(Br)nc12>>COc1nc2c(Cl)cccc2s1,,O,,[Na+].[OH-],,val
US20100069381A1,Cc1nnc(-c2ccc3occ(Br)c3c2)o1.OB(O)c1ccc(F)cc1>>Cc1nnc(-c2ccc3occ(-c4ccc(F)cc4)c3c2)o1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20030232824A1,Cc1noc(=O)c2ccc(N)cc12.O=C(O)C(=O)CC1(c2cccc(C(F)(F)F)c2)CC1>>Cc1noc(=O)c2ccc(NC(=O)C(=O)CC3(c4cccc(C(F)(F)F)c4)CC3)cc12,,CC(=O)N(C)C,,O=S(Cl)Cl,,val
US20160244429A1,Cc1ccc(S(=O)(=O)OCCCc2c[nH]c3ccc(F)cc23)cc1.O=c1c2ccoc2ccn1-c1ccc(N2CCNCC2)cc1>>O=c1c2ccoc2ccn1-c1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)cc1,,CC#N,,[I-].[K+],,val
US20070135452A1,CCCN(CCC)c1ccnc(N)c1.Cc1cc(C)c(N=C=S)c(C)c1>>CCCN(CCC)c1ccnc(NC(=S)Nc2c(C)cc(C)cc2C)c1,,CO,O,,,val
US06300316B1,COC1CN(C(=O)CN)Cc2ccccc21>>COC1CN(CCN)Cc2ccccc21,,C1CCOC1,,,,val
US04838931,CC(C)(C)C(=O)Cl.COc1cc(NC(=O)N2CCCCC2CO)c(F)cc1Cl>>COc1cc(NC(=O)N2CCCCC2COC(=O)C(C)(C)C)c(F)cc1Cl,,Cc1ccccc1,,c1ccncc1,,val
US20120196891A1,CCO.Fc1cnccc1-c1nc2cc(C(F)(F)F)cnc2s1>>CCOc1cnccc1-c1nc2cc(C(F)(F)F)cnc2s1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20120094996A1,CS(=O)(=O)c1ccc(B(O)O)cc1.Nc1ncc(-c2nn3c(I)cnc3s2)cc1C(F)(F)F>>CS(=O)(=O)c1ccc(-c2cnc3sc(-c4cnc(N)c(C(F)(F)F)c4)nn23)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US04444776,CC(=O)Nc1cc(C)c2c(=O)[nH]ccc2c1C>>Cc1c(N)cc(C)c2c(=O)[nH]ccc12,,O,,CCO,Cl,val
US20050014765A1,CC(C)(C)OC(=O)N1CCN(c2cccc(C#N)c2)CC1>>N#Cc1cccc(N2CCNCC2)c1,,C1COCCO1,,Cl,,val
US20130116229A1,CCn1cc(C(=O)OC)c2cc(O)c(OC)cc2c1=O.OCCCc1ccc2ccccc2n1>>CCn1cc(C(=O)OC)c2cc(OCCCc3ccc4ccccc4n3)c(OC)cc2c1=O,,C1CCOC1,CCOC(C)=O,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030176439A1,CC(Br)c1ccccc1.N#Cc1ccc(N=C=O)cc1.Nc1ccccc1N>>CC(Nc1ccccc1NC(=O)Nc1ccc(C#N)cc1)c1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070249670A1,COC(=O)[C@@H](N)[C@H](C)OCc1ccccc1.Nc1cc2ccccc2cc1C(=O)O>>COC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1N)[C@@H](C)OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05242890,CCOC(=O)c1noc(COc2ccc(Cl)cc2Cl)n1.CC[Mg]Br>>CCC(=O)c1noc(COc2ccc(Cl)cc2Cl)n1,,C1CCOC1,,Cl,,val
US20060160864A1,CC(C)CNCC(C)C.O=Cc1cc(Br)ccc1F>>CC(C)CN(CC(C)C)c1ccc(Br)cc1C=O,,CS(C)=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20030229120A1,N#CCSc1ccc(C(=O)O)cc1.[N-]=[N+]=[N-].[NH4+]>>O=C(O)c1ccc(SCc2nn[nH]n2)cc1,,CN(C)C=O,,[Cl-].[Na+],,val
US06534135B1,COc1ccc(C=O)cc1OC.COc1ccc(CC#N)cc1OC>>COc1ccc(C=C(C#N)c2ccc(OC)c(OC)c2)cc1OC,,CCO,,C,C[O-].[Na+],val
US20040072818A1,Clc1ccc2c(N3CCNCC3)ccnc2c1.Nc1ccncc1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>O=C(Nc1ccncc1)N1CCN(c2ccnc3cc(Cl)ccc23)CC1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20090099155A1,CC1(C)CCCC(Oc2ccc(CN)cc2)C1.O=C(N1CCc2ccc(Cl)c(OS(=O)(=O)C(F)(F)F)c2CC1)C(F)(F)F>>CC1(C)CCCC(Oc2ccc(CNc3c(Cl)ccc4c3CCN(C(=O)C(F)(F)F)CC4)cc2)C1,,C1COCCO1,,,,val
US20120309966A1,CN1CCC(C(=O)NCc2nccnc2Cl)CC1>>CN1CCC(c2ncc3c(Cl)nccn23)CC1,,CC#N,,O=P(Cl)(Cl)Cl,,val
US20030236296A1,C=CCOC(=O)NC(C=O)CC(=O)OC(C)(C)C.CCO.CCOC([O-])[O-]>>C=CCOC(=O)NC(CC(=O)OC(C)(C)C)C(OCC)OCC,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120258952A1,CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(CC=O)ccn34)c12.CN1CCNCC1>>CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(CCN5CCN(C)CC5)ccn34)c12,CC(=O)O,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05281747,CC(C)COP(C)(=O)C[C@@H](O)CN>>CP(=O)(O)C[C@@H](O)CN,,Cl,,,,val
US20160158377A1,Br.CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@@H](Br)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O,,CC(=O)O,,,,val
US20090076101A1,O=C(O)c1ccc(B(O)O)cc1.O=C(c1ccc(Br)s1)C(F)(F)F>>O=C(O)c1ccc(-c2ccc(C(=O)C(F)(F)F)s2)cc1,,CN(C)C=O,,,,val
US05633379,COC(=O)c1ccc(Cl)cc1NC(=O)CSCCCc1ccccc1>>O=c1[nH]c2cc(Cl)ccc2c(O)c1SCCCc1ccccc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US03994940,CN(C)CCc1nnc(CO)n1-c1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1Cl.O=C1NC(=O)c2ccccc21>>CN(C)CCc1nnc(CN2C(=O)c3ccccc3C2=O)n1-c1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1Cl,,COCCOC,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020183327A1,COc1ccccc1C=O.Nc1ccc(Br)cn1.[C-]#[N+]C(C)(C)CC(C)(C)C>>COc1ccccc1-c1nc2ccc(Br)cn2c1NC(C)(C)CC(C)(C)C,,[O-][Cl+3]([O-])([O-])O,,,,val
US20040259910A1,CCOC(=O)C(CNC(=O)Cc1cccc(OC(C)CC)c1)c1ccc(OC)c(OC)c1>>CCOC(=O)C1CN=C(Cc2cccc(OC(C)CC)c2)c2cc(OC)c(OC)cc21,,ClCCl,,ClP(Cl)(Cl)(Cl)Cl,,val
US04689348,C=CCN.CSC(=NC#N)NC1CCCc2ccccc21>>C=CCNC(=NC#N)NC1CCCc2ccccc21,,CCO,,,,val
US20160039788A1,C#CCCCNC1CCC(=O)NC1=O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C#CCCCN(C(=O)OC(C)(C)C)C1CCC(=O)NC1=O,CN(C)c1ccncc1,CC#N,,,,val
US20070066607A1,CCCCc1ccc2c(c1)CCC2=O.NO>>CCCCc1ccc2c(c1)CCC2=NO,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20140221584A1,BrBr.COc1cccc(CBr)c1>>COc1ccc(Br)c(CBr)c1,,ClC(Cl)Cl,,CCCCCC,,val
US20140031208A1,C#CCN.O=C1CCC(=O)O1>>C#CCNC(=O)CCC(=O)O,,C1CCOC1,,,,val
US20110213003A1,CC(C)(C)OC(=O)c1ccc(/C=N/[S@@](=O)C(C)(C)C)s1.C[Mg]Br>>C[C@@H](N[S@@](=O)C(C)(C)C)c1ccc(C(=O)OC(C)(C)C)s1,,ClCCl,,[Cl-].[NH4+],,val
US20070275954A1,C#CCN.O=C1Nc2ncccc2C(c2ccco2)=NC1c1cccs1>>C#CCNC1=Nc2ncccc2C(c2ccco2)=NC1c1cccs1,Cl[Ti](Cl)(Cl)Cl,C1CCOC1,,,,val
US20100249163A1,COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(O)c2ccccc2)C2CC2)cc(OCCOC)c1>>COCCCc1cc(CN(C(=O)C2CNCCC2(O)c2ccccc2)C2CC2)cc(OCCOC)c1,,ClCCl,,Cl,,val
US20120157428A1,CCOC(=O)C1(c2cc(C)no2)CC1.O=C1CCC(=O)N1Br>>CCOC(=O)C1(c2onc(C)c2Br)CC1,,CN(C)C=O,,O,,val
US05776937,COC(=O)CCN1CCN(CC2CN(C3CCN(C(=O)OC(C)(C)C)CC3)C(=O)O2)CC1>>CC(C)(C)OC(=O)N1CCC(N2CC(CN3CCN(CCC(=O)O)CC3)OC2=O)CC1,,CO,,[Na+].[OH-],,val
US20080161566A1,Br.CC1(C)CC(c2ccccc2N2CCN(CC3CC3)CC2)CC(C)(C)C1>>Br.CC1(C)CC(c2ccccc2N2CCN(CC3CC3)CC2)CC(C)(C)C1,,CCOC(C)=O,,CO,,val
US20160152742A1,CC(C)(C)OCCCCCCCl.NC(N)=S>>CCCCCC(S)OC(C)(C)C,,O,,[Na+].[OH-],,val
US20070105842A1,NNc1ccccc1.O=CNC(=O)Cc1ccccc1>>c1ccc(Cc2ncnn2-c2ccccc2)cc1,,CC(=O)O,,CCN(CC)CC,Cl,val
US20110218192A1,COCCCl.Oc1cccc(Br)c1>>COCCOc1cccc(Br)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150175628A1,CC(=O)NCC(=O)O.COc1cc(Br)ccc1C(=O)NN>>COc1cc(Br)ccc1C(=O)NNC(=O)CNC(C)=O,,C1CCOC1,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US20030134840A1,CC(C)(C)OC(=O)NCCN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1.O=C(O)C(F)(F)F>>NCCN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20120101053A1,CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)CC(=O)OCc1ccccc1>>CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)CC(=O)O,,C1CCOC1,CO,[Li+].[OH-],,val
US20100311966A1,COC(=O)[C@H](CO)NC(=O)c1ccc([N+](=O)[O-])c(OC)c1>>COC(=O)C1COC(c2ccc([N+](=O)[O-])c(OC)c2)=N1,,C1CCOC1,,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US20050107381A1,CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cnc(C=O)cn1>>CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cnc(CO)cn1,,CO,,[BH4-].[Na+],,val
US20140107334A1,CCOC(=O)Cl.COc1cc2c(cc1OC)C(N)C2>>CCOC(=O)NC1Cc2cc(OC)c(OC)cc21,,CCN(CC)CC,ClCCl,Cl,,val
US20100087428A1,Cn1ccc(S(=O)(=O)N(Cc2ccc(Cl)cc2)c2cccc(C(=O)O)c2)n1.NCCO>>Cn1ccc(S(=O)(=O)N(Cc2ccc(Cl)cc2)c2cccc(C(=O)NCCO)c2)n1,,CC#N,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04368205,CC(=O)OC1CCc2c(-c3cccs3)cccc21>>OC1CCc2c(-c3cccs3)cccc21,,CCO,O,[K+].[OH-],,val
US05663162,CN(Cc1ncc2sccn12)C(=O)C(F)(F)F>>CNCc1ncc2sccn12,,CO,,[Na+].[OH-],,val
US20150361060A1,CCOC(=O)C=NO.NCCN1CC2CCC(C2)C1>>O=C(C=NO)NCCN1CC2CCC(C2)C1,,CCO,,,,val
US20080255147A1,COc1ccccc1B(O)O.Clc1nsc(Cl)n1>>COc1ccccc1-c1nc(Cl)ns1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20120171665A1,O=C1NC(=O)c2ccccc21.OCc1c(Br)cncc1Br>>O=C1c2ccccc2C(=O)N1Cc1c(Br)cncc1Br,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130196993A1,CC(C)/C=C/C(=O)O.Cc1cc(NCCN)c2ccccc2n1>>C/C=C/C(=O)NCCNc1cc(C)nc2ccccc12,,CC#N,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040127549A1,COC(=O)C1(C)N=C(c2ccccc2)OC1C>>C[C@@H](O)[C@@](C)(N)C(=O)O,,CCOCC,,Cl,O,val
US20030087902A1,O=Cc1cccc(OCC2CC2)c1>>OCc1cccc(OCC2CC2)c1,,CO,,[BH4-].[Na+],,val
US04145217,CC(=O)C(=O)CBr.COc1cc([N+](=O)[O-])c([N+](=O)[O-])cc1OC>>COc1cc2nc(C)c(CBr)nc2cc1OC,[Pd],CC(=O)O,,,,val
US20120190649A1,CC(C)(C)[Si](C)(C)Oc1ccc2cc(Br)ccc2c1.CN(C)C=O>>CC(C)(C)[Si](C)(C)Oc1ccc2cc(C=O)ccc2c1,,C1CCOC1,,[Li]CCCC,,val
US04374137,CCOC(=O)Cl.COc1cc2c(cc1OC)C1(Cc3ccccc3O1)CN(C)C2>>CCOC(=O)N1Cc2cc(OC)c(OC)cc2C2(Cc3ccccc3O2)C1,,c1ccccc1,,O,O=C([O-])[O-].[K+].[K+],val
US20130053364A1,C1CCOC1.COC(=O)c1c(CS(=O)(=O)c2ccccc2)ccc(Br)c1OC>>CCc1ccc(CS(=O)(=O)c2ccccc2)c(C(=O)OC)c1OC,,O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20150057286A1,Cc1cc(Cl)cnc1C(=O)O.O=S(Cl)Cl>>Cc1cc(Cl)cnc1C(=O)Cl,,CN(C)C=O,,Cc1ccccc1,,val
US20060035938A1,CO.O=C(O)c1ccc(CBr)n(-c2cccc(C(F)(F)F)c2)c1=O>>COCc1ccc(C(=O)O)c(=O)n1-c1cccc(C(F)(F)F)c1,,CO,,C[O-].[Na+],,val
US20020198197A1,Cc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2ccnc(C#N)c2)cc1C(F)(F)F>>Cc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1ccnc(C#N)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US04806642,CCCCO.c1ccc(COCC2CO2)cc1>>CCCCOCC(O)COCc1ccccc1,,CN(C)C=O,O,[H-].[Na+],,val
US04950677,CCOc1ccnc(CCl)c1C.FC(F)(F)c1ccc2nc(S)[nH]c2c1>>CCOc1ccnc(CSc2nc3ccc(C(F)(F)F)cc3[nH]2)c1C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080269220A1,CCOCCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)cc3)c2)c(C)c1.Cl>>CCOCCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)cc3)c2)c(C)c1.Cl,,CCOC(C)=O,,,,val
US20110230458A1,CC(C)(C)OC(=O)N1CCC(O)C(N=[N+]=[N-])C1>>CC(C)(C)OC(=O)N1CCC(=O)C(N=[N+]=[N-])C1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20150175602A1,CC(C)(C)OC(=O)N1CCC(OS(C)(=O)=O)CC1.Fc1cccc(S)c1>>CC(C)(C)OC(=O)N1CCC(Sc2cccc(F)c2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150340519A1,Cc1ccc(S(=O)(=O)Cl)cc1.OC12CC3CC(CC(C3)C1)C2>>C1C2CC3CC1CC(C2)C3.Cc1ccc(S(=O)(=O)O)cc1,,ClCCl,,CCN(CC)CC,,val
US05939446,COCCOCN(c1onc(C)c1C)S(=O)(=O)c1ccccc1Br.O=S(=O)(c1ccccc1)n1cc(B(O)O)c2ccccc21>>COCCOCN(c1onc(C)c1C)S(=O)(=O)c1ccccc1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12,,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20060106016A1,C=C1CC(NC(=O)OC(C)(C)C)C(C(=O)Nc2ccc(Cl)cc2)C1>>C=C1CC(N)C(C(=O)Nc2ccc(Cl)cc2)C1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20090298878A1,O=C(O)c1ccc2[nH]cnc2c1>>OCc1ccc2nc[nH]c2c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140155381A1,C=O.Cc1ccc(C#N)c(N)c1.[BH3-]C#N>>Cc1ccc(C#N)c(N(C)C)c1,,CC#N,,CC(=O)O,,val
US04593104,Cc1cccc(C)c1N(CCl)C(=O)CCl.c1nc[nH]n1>>Cc1cccc(C)c1N(Cn1cncn1)C(=O)CCl,,C1CCOC1,,,,val
US04039589,C=C[Mg]Cl.O=C(c1ccccc1)c1ccc(O)cc1>>C=CC(O)(c1ccccc1)c1ccc(O)cc1,,C1CCOC1,,CCOCC,[Cl-].[NH4+],val
US04327222,COc1ccc(CC(=O)c2ccc(OC)cc2)cc1.NO>>COc1ccc(CC(=NO)c2ccc(OC)cc2)cc1,,CO,O,Cl,[Na+].[OH-],val
US20110263548A1,CCCc1cnc(N2CCC(CS(=O)(=O)[O-])CC2)nc1.O=c1cc(O)cc[nH]1>>CCCc1cnc(N2CCC(Oc3cc[nH]c(=O)c3)CC2)nc1,,O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20080213187A1,COC(=O)c1cc(N)cc(C(=O)OC)c1.O=C(Cl)c1ccc(-c2ccccc2)cc1>>COC(=O)c1cc(NC(=O)c2ccc(-c3ccccc3)cc2)cc(C(=O)OC)c1,,ClCCl,,,,val
US20110274638A1,Br[Mg]c1ccccc1.CC(C)(C)OC(=O)N1CC(=O)C1>>CC(C)(C)OC(=O)N1CC(O)(c2ccccc2)C1,,C1CCOC1,CCOCC,Cl,[Cl-].[NH4+],val
US20150111885A1,CCS(=O)(=O)Cl.Cn1cc(-c2cc(N)ccc2Oc2ccc(F)cc2F)ccc1=O>>CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2ccc(=O)n(C)c2)c1,,ClCCl,,O,,val
US20120022098A1,OC(c1c(F)ccc(OCc2ccccc2)c1F)c1c[nH]c2ncc(-c3cccnc3)cc12>>O=C(c1c(F)ccc(OCc2ccccc2)c1F)c1c[nH]c2ncc(-c3cccnc3)cc12,,C1CCOC1,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090118305A1,N#Cc1cccc(N)c1O.Nc1ncccc1C=O>>N#Cc1cccc2c1OC(c1cccnc1N)N2,,CO,,,,val
US06310208B1,CCc1c(OC)cc(C2CN(C)CCC2=O)cc1OC.COC(=O)CP(=O)(OC)OC>>CCc1c(OC)cc(C2CN(C)CC/C2=C\C(=O)OC)cc1OC,,C1CCOC1,,[H-].[Na+],,val
US20120101127A1,CC1(C)CC(c2cccc(N)c2)Nc2ccc(Cl)cc21.CCS(=O)(=O)Cl>>CCS(=O)(=O)Nc1cccc(C2CC(C)(C)c3cc(Cl)ccc3N2)c1,,c1ccncc1,,,,val
US06673786B1,CC(C)(C)OC(=O)NCc1ccc(CCC(=O)N2CCN(C(=O)OCc3ccccc3)CC2)cc1>>CC(C)(C)OC(=O)NCc1ccc(CCC(=O)N2CCNCC2)cc1,,CO,,,,val
US20020052512A1,CCCC[Sn](CCCC)(CCCC)c1ccc(C(=O)ON2C(=O)CCC2=O)c(Cl)c1.N[C@@H](CNC(=O)c1cccs1)C(=O)O>>CCCC[Sn](CCCC)(CCCC)c1ccc(C(=O)N[C@@H](CNC(=O)c2cccs2)C(=O)O)c(Cl)c1,,CN(C)C=O,,,,val
US20030166639A1,CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2F)cc1NC(=O)CC(=O)c1cccc(-c2cccnc2)c1>>O=C1CC(c2cccc(-c3cccnc3)c2)=Nc2ccc(-c3ccccc3F)cc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110275637A1,C1COCCN1.Cc1cc(COC(=O)Oc2ccc([N+](=O)[O-])cc2)cc(C)n1.Cl>>Cc1cc(COC(=O)N2CCOCC2)cc(C)n1.Cl,CN(C)c1ccncc1,CCOCC,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20060111375A1,CCOC(=O)c1c(C)cccc1O.COc1cc2nccc(Cl)c2cc1OC>>CCOC(=O)c1c(C)cccc1Oc1ccnc2cc(OC)c(OC)cc12,CN(C)c1ccncc1,Clc1ccccc1Cl,,,,val
US20100160255A1,CC1(C)CC2(CCCN(C3CCN(C(=O)c4cc(Br)cc(-c5cccnc5)c4)CC3)C2)C(=O)O1.OB(O)c1ccccc1>>CC1(C)CC2(CCCN(C3CCN(C(=O)c4cc(-c5ccccc5)cc(-c5cccnc5)c4)CC3)C2)C(=O)O1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20140073589A1,C[C@@H](Cc1ccccc1)NC(=O)[C@@H](C)O[C@H]1[C@@H]2O[C@H](c3ccccc3)OC[C@H]2O[C@@H](OCc2ccccc2)[C@@H]1NC(=O)OC(C)(C)C>>C[C@@H](Cc1ccccc1)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OCc2ccccc2)[C@@H]1N,,CO,,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US04714765,Cc1cc(C=C2SC(=S)N(CC(=O)O)C2=O)on1>>Cc1cc(CC2SC(=S)N(CC(=O)O)C2=O)on1,[Pd],O,,O=C([O-])O.[Na+],,val
US20040152719A1,COc1ccc(CO)cc1.N#Cc1cc(Cl)ccc1N>>COc1ccc(CNc2ccc(Cl)cc2C#N)cc1,,CC#N,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04839363,CN1C[C@H](C(=O)CC=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21.NO>>CN1C[C@H](c2ccno2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21,,CC(=O)O,,Cl,,val
US20130217668A1,O=C1NC(=O)C2(CCC3(CC2)OCCO3)N1>>O=C1CCC2(CC1)NC(=O)NC2=O,,CCO,,Cl,,val
US20120065196A1,CC(C)(C)OC(=O)NCCNC(=O)[C@@H]1CC[C@@H](C(=O)c2ccccc2)CC1.Cl>>Cl.NCCNC(=O)[C@@H]1CC[C@@H](C(=O)c2ccccc2)CC1,,ClCCl,,,,val
US20160221945A1,COc1nn(-c2ccc(C(F)(F)F)nc2)cc1CNC(=O)[C@@H]1[C@@H](F)CCN1C(=O)OC(C)(C)C.Cl>>COc1nn(-c2ccc(C(F)(F)F)nc2)cc1CNC(=O)[C@H]1NCC[C@@H]1F.Cl,,C1COCCO1,,,,val
US04943574,Cn1nnc2ccc(C(Cl)c3ccc(C4=NC(C)(C)CO4)cc3)cc21.c1c[nH]cn1>>Cn1nnc2ccc(C(c3ccc(C4=NC(C)(C)CO4)cc3)n3ccnc3)cc21,,CC#N,,,,val
US20050215578A1,Clc1nc(SCOCc2ccccc2)ns1.OCc1ccccc1>>c1ccc(COCSc2nsc(OCc3ccccc3)n2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20110124578A1,CC(C)(C)OC(=O)NCC(=O)O.CC(C)CNCC(C)C>>CC(C)CN(CC(C)C)C(=O)CNC(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20070010670A1,O=C(O)c1cc(I)c(O)c(I)c1.O=S(Cl)Cl>>O=C(Cl)c1cc(I)c(O)c(I)c1,,COCCOC,,,,val
US20110251181A1,C[C@@H]1CCc2ncnc(C3=CCN(C(=O)OC(C)(C)C)CC3)c21>>C[C@@H]1CCc2ncnc(C3CCN(C(=O)OC(C)(C)C)CC3)c21,[Pd],CCOC(C)=O,,,,val
US20160087309A1,CC(C)(CO)CO.O=C(Cl)C(=O)Cl>>CC1(C)COC(=O)C(=O)OC1,,C1CCOC1,,c1ccncc1,,val
US20070148164A1,CC(C)(C)OC(=O)NCc1cccc(-c2cc(C#N)cc(Oc3nc(-c4ccccc4C(=O)O)c(F)cc3F)c2)c1>>N#Cc1cc(Oc2nc(-c3ccccc3C(=O)O)c(F)cc2F)cc(-c2cccc(CN)c2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090203705A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cccnn1>>CC(C)(C)OC(=O)Nc1cccnn1,CN(C)c1ccncc1,ClCCl,,Cl,O,val
US04379819,CS.O=[N+]([O-])c1ccc(Cl)cc1>>CSc1ccc([N+](=O)[O-])cc1,,CCO,CN(C)C=O,[K+].[OH-],,val
US20030129158A1,C=CCN(C)C.O=S(=O)(O)c1ccc(N=C=S)cc1.[Na]>>NC(=S)Nc1ccc(S(=O)(=O)O)cc1.[Na],,O,,,,val
US20160130237A1,C=CC(=O)Cl.COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CN(C)C)cc3N)ncn2)c1Cl>>C=CC(=O)Nc1cc(CN(C)C)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1,,C1CCOC1,,,,val
US20130096144A1,COc1cc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)ccn1>>COc1cc(C[C@@H](CO)NC(=O)OC(C)(C)C)ccn1,,C1CCOC1,C1CCOC1,,,val
US04657579,COc1ncnc(OC)c1N.O=C(Cl)CCl>>COc1ncnc(OC)c1NC(=O)CCl,,ClCCl,,,,val
US20070010511A1,COCCCN1C(=O)CCc2ccc(COC3CN(C(=O)OC(C)(C)C)CCC3c3ccc(OCCCC#N)cc3)cc21>>COCCCN1C(=O)CCc2ccc(COC3CN(C(=O)OC(C)(C)C)CCC3c3ccc(OCCCCN)cc3)cc21,[Ni],N,,,,val
US20130237502A1,CC(C)(C)OC(=O)N1C(CF)C(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)OC1(C)C.N#Cc1ncc(Br)cn1>>CC(C)(C)OC(=O)N1C(CF)C(c2ccc(-c3cnc(C#N)nc3)cc2)OC1(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20020091273A1,COc1cc2cc(C(=O)OC(C)(C)C)c(N)cc2cc1OCCN1CCOCC1.NC=O>>COc1cc2cc3c(=O)[nH]cnc3cc2cc1OCCN1CCOCC1,,CO,ClCCl,,,val
US20090298836A1,NNC(N)=S.O=C(O)c1cc2c(Cl)cncc2s1>>NC(=S)NNC(=O)c1cc2c(Cl)cncc2s1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US04054570,CC(O)(c1ccccc1)C1CCNCC1.O=C(CCCCl)c1ccc(F)cc1>>CC(O)(c1ccccc1)C1CCN(CCCC(=O)c2ccc(F)cc2)CC1,,CC(=O)CC(C)C,,[I-].[Na+],,val
US20150080549A1,C#CCCC(=O)O.CC(C)(C)O>>C#CCCC(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060229294A1,BrBr.Cc1cccc(S)c1C#N>>Cc1cccc2snc(Br)c12,,CCOC(C)=O,,,,val
US20080167371A1,CC(C)CCN.Cc1cc(C=O)ccc1Br>>Cc1cc(CNCCC(C)C)ccc1Br,,CO,,[BH4-].[Na+],,val
US04402960,COc1ccc(-c2nc(S)[nH]c2-c2ccc(OC)cc2)cc1.O=[N+]([O-])c1cc(C(F)(F)F)ccc1Cl>>COc1ccc(-c2nc(Sc3ccc(C(F)(F)F)cc3[N+](=O)[O-])[nH]c2-c2ccc(OC)cc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20120077760A1,N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F.O=C(O)[C@@H](O)c1ccccc1>>N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F.O=C([O-])[C@@H](O)c1ccccc1,,CCO,,,,val
US20070149562A1,O=C1CCC(N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCC(Cn3cncn3)(C3CCCCC3)CC2)CC1.c1ccc2c(c1)CNC2>>O=C([C@@H](Cc1ccc(Cl)cc1)NC1CCC(N2Cc3ccccc3C2)CC1)N1CCC(Cn2cncn2)(C2CCCCC2)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070112002A1,CCC1(CC)CCC(c2cc(N3CCC[C@H](OC)C3)ccc2N2CCN(C(=O)OC(C)(C)C)CC2)CC1>>CO[C@H]1CCCN(c2ccc(N3CCNCC3)c(C3CCC(C)(C)CC3)c2)C1,O,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20040254186A1,O=C1CCC(=O)N1Br.O=C1CCc2cc(-c3ccoc3-c3ccncc3)ccc21>>O=C1CCc2cc(-c3cc(Br)oc3-c3ccncc3)ccc21,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US04695575,Nc1cncnc1NCCN1CCC(Cc2nc3ccccc3n2Cc2ccc(F)cc2)CC1.S=C=S>>Fc1ccc(Cn2c(CC3CCN(CCn4c(S)nc5cncnc54)CC3)nc3ccccc32)cc1,,O,,CN(C)C=O,,val
US20160016951A1,Nc1ccnc(Cl)c1Br.O=C1CCC(=O)N1I>>Nc1c(I)cnc(Cl)c1Br,,CC(=O)O,,,,val
US20070142386A1,COc1nc2nc(SCc3cccc(F)c3F)nc(N[C@@H](CO)CC(C)C)c2s1>>CC(C)C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]c(=O)sc12,,C1COCCO1,,Cl,O,val
US04997950,CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)ON1C(=O)CCC1=O.NCCC(=O)O>>CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCCC(=O)O,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20090270443A1,CCOC(C)(OCC)OCC.Cc1nc(Cl)c(N)c(NNC(=O)OC(C)(C)C)c1C>>Cc1nc(Cl)c2nc(C)n(NC(=O)OC(C)(C)C)c2c1C,,Cc1ccccc1,,Cl,c1ccncc1,val
US04399147,CCCCC[C@@H](/C=C/[C@H]1[C@H](OC2CCCCO2)C[C@@H]2OC(CCCCC(=O)OC)C[C@@H]21)OC1CCCCO1>>CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@H]2OC(CCCCC(=O)OC)C[C@@H]21,,C1CCOC1,CC(=O)O,,,val
US20080090855A1,O=C1NCCCN1.O=[N+]([O-])c1ccc(CBr)cc1>>O=C1NCCCN1Cc1ccc([N+](=O)[O-])cc1,,CN(C)C=O,,[I-].[K+],,val
US20080200471A1,CCc1n[nH]c2cc(Br)ccc12.COc1ccc(CCl)cc1>>CCc1nn(Cc2ccc(OC)cc2)c2cc(Br)ccc12,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20080207654A1,CCCc1nc(C)n(-c2ccc(OC3CCC3)c(F)c2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCc1nc(C)n(-c2ccc(OC3CCC3)c(F)c2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20030166637A1,C[C@H]1CNCCN1.Clc1ccc2ccccc2n1>>C[C@H]1CN(c2ccc3ccccc3n2)CCN1,,CCCCO,,,,val
US20150203486A1,Cc1nc2ccc(-c3cnc(N4CCC(C)(C(=O)O)CC4)nc3)cn2c1Cc1ccccc1OC(F)F.OCCN1CCOCC1>>Cc1nc2ccc(-c3cnc(N4CCC(C)(C(=O)OCCN5CCOCC5)CC4)nc3)cn2c1Cc1ccccc1OC(F)F,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US06291475B1,C=CC(=O)Cl.Nc1ccccc1>>C=CC(=O)Nc1ccccc1,,C1CCOC1,,,,val
US20150266895A1,NC(=O)NC(c1ccccc1)C1CCCO1>>NC(=O)N[C@@H](c1ccccc1)[C@@H]1CCCO1,,CO,,,,val
US20130131051A1,CC(C)(C)OC(=O)NC1=N[C@]2(C)c3cc(N=[N+]=[N-])ccc3CC[C@@H]2CS1>>CC(C)(C)OC(=O)NC1=N[C@]2(C)c3cc(N)ccc3CC[C@@H]2CS1,[Pd],CO,,,,val
US20130059849A1,CCOC(=O)c1cc(-c2cccnc2)nc2c1c(C)nn2C(C)(C)C>>Cc1nn(C(C)(C)C)c2nc(-c3cccnc3)cc(C(=O)O)c12,,CCO,,[Na+].[OH-],,val
US20160000760A1,CSC(NC#N)Nc1ccc(I)cc1.NN>>Nc1nc(Nc2ccc(I)cc2)n[nH]1,,CCO,,,,val
US20080207616A1,CC(C)(C#N)c1cc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cs1>>CC(C)(C#N)c1cc(CO)cs1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20070141684A1,CCC[C@@H](C)CO.CS(=O)(=O)Cl>>CCC[C@@H](C)COS(C)(=O)=O,,COC(C)(C)C,,CCN(CC)CC,Cl,val
US20040235865A1,C1CN=C2CCCN2C1.CCOC(=O)C(C(=O)OCC)c1c(F)cccc1Cl.Nc1ncc[nH]1>>C1CN=C2CCCN2C1.Oc1nc2nccn2c(O)c1-c1c(F)cccc1Cl,,CN(C)C=O,,Cl,,val
US20130059834A1,CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3c4c(n(C)[n+]3[O-])CCCC4)nc12>>CC(C)NC(=O)c1c[nH]c2ncc(-c3c4c(n(C)[n+]3[O-])CCCC4)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040082561A1,C1CN2CCN1CC2.O=C1C(CCC(O)c2ccc(F)cc2)C(c2ccc(OCc3cccc(CBr)c3)cc2)N1c1ccc(F)cc1>>O=C1C(CCC(O)c2ccc(F)cc2)C(c2ccc(OCc3cccc(C[N+]45CCN(CC4)CC5)c3)cc2)N1c1ccc(F)cc1.[Br-],,Cc1ccccc1,,,,val
US20090286778A1,N#Cc1ccc(N=C=O)cc1.O=C(COc1ccc2cc1CCc1cccc(c1)Nc1ncc(Cl)c(n1)N2)N1CCNCC1.O=C(O)C(F)(F)F>>N#Cc1ccc(NC(=O)N2CCN(C(=O)COc3ccc4cc3CCc3cccc(c3)Nc3ncc(Cl)c(n3)N4)CC2)cc1.O=C(O)C(F)(F)F,,CN(C)C=O,,CCN(CC)CC,ClCCl,val
US20070066604A1,CI.OCCCc1ncc2ccc(Br)cn12>>COCCCc1ncc2ccc(Br)cn12,,CN(C)C=O,,[H-].[Na+],,val
US05248684,CCCC(=O)OC(=O)CCC.O=C1Nc2ccccc2C1=O>>CCc1c(C(=O)O)c2ccccc2[nH]c1=O,,c1ccncc1,,Cl,[Na+].[OH-],val
US20080139505A1,CC(=O)c1ccc(OCc2ccc(C(OC3CCCCO3)c3cccc(-c4nnc(S)[nH]4)c3)cc2)c(C)c1O>>CC(=O)c1ccc(OCc2ccc(C(O)c3cccc(-c4nnc(S)[nH]4)c3)cc2)c(C)c1O,,CCOC(C)=O,CO,Cc1ccc(S(=O)(=O)O)cc1,,val
US20160185778A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.O=C(Cl)C1CCCO1>>CC(C)(C)OC(=O)N1CCC(=O)C(C(=O)C2CCCO2)C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20110144136A1,CCCCOc1nc(N)c2nc(OC)[nH]c2n1.O=C(OCc1ccccc1)N1CCCCC1CCCBr>>CCCCOc1nc(N)c2nc(OC)n(CCCC3CCCCN3C(=O)OCc3ccccc3)c2n1,,CN(C)C=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20160046605A1,COC(=O)c1nc(-c2ncccc2F)cnc1N>>Nc1ncc(-c2ncccc2F)nc1C(=O)O,,CO,O,[Li+].[OH-],,val
US20120214802A1,C[N+](=O)[O-].O=Cc1ccccc1>>O=[N+]([O-])CCc1ccccc1,,CO,O,Cl,[Na+].[OH-],val
US20090163520A1,Nc1ccc(-n2ncc3c(N)ncnc32)cc1.O=S(=O)(Cl)c1cccs1>>Nc1ncnc2c1cnn2-c1ccc(NS(=O)(=O)c2cccs2)cc1,,CO,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20090298815A1,CCOC(=O)c1cccc(N)c1.O=S(=O)(Cl)c1c(F)cccc1F>>CCOC(=O)c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1,,ClCCl,,c1ccncc1,,val
US08080566B1,COC(=O)c1ccccc1N.O=N[O-]>>COC(=O)c1ccccc1NN,,Cl,O,Cl[Sn]Cl,,val
US20100048556A1,O=c1[nH]c2cc(Br)ccc2n2c(C3CCCCC3)ncc12.c1cn[nH]c1>>O=c1[nH]c2cc(-n3cccn3)ccc2n2c(C3CCCCC3)ncc12,I[Cu]I,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05935973,NCC1CCNCC1.O=Cc1cc(Br)ccc1O>>Oc1ccc(Br)cc1C=NCC1CCNCC1,,CCO,,,,val
US20090044345A1,O=S(Cl)Cl.OCc1cc(-n2cccc2)ccn1>>ClCc1cc(-n2cccc2)ccn1,,ClCCl,,O,,val
US20030050310A1,O.O=C(CC(Cc1ccccc1)S(=O)N1CCC(Cc2ccccc2)CC1)OCc1ccccc1>>O=C(CC(Cc1ccccc1)S(=O)(=O)N1CCC(Cc2ccccc2)CC1)OCc1ccccc1,,CC#N,ClCCl,CCOC(C)=O,,val
US20100144786A1,COC(=O)CBr.Nc1cc(O)ccc1F>>COC(=O)COc1ccc(F)c(N)c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20020119093A1,O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].[Ce+3]>>O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].[Ce+3],,O,,,,val
US20140179672A1,CC(C#N)(CF)NC(=O)OCc1ccccc1>>CC(CN)(CF)NC(=O)OCc1ccccc1,[Ni],CO,N,[H][H],,val
US04734424,O=C(O)C(F)(F)CCCBr.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(O)C(F)(F)CCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-],,Cc1ccccc1,,CC#N,,val
US05591849,CCOC(=O)C1(NC(=O)CNC)CCc2ccccc2C1>>CN1CC(=O)NC2(CCc3ccccc3C2)C1=O,,C1CCOC1,,[Na+].[OH-],,val
US04673746,Brc1ccccn1.COc1ccc(C=O)c(Cl)c1Cl>>COc1ccc(C(O)c2ccccn2)c(Cl)c1Cl,,C1CCOC1,,O,[Li]CCCC,val
US20100137299A1,O=C1N(C(c2ccccc2)c2ccccc2)c2cc3c(cc2C12COc1cc4c(cc12)CCO4)OCCO3>>O=C1Nc2cc3c(cc2C12COc1cc4c(cc12)CCO4)OCCO3,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20050197380A1,COC(=O)c1cc2ccc3c(c2[nH]1)OCCO3>>O=C(O)c1cc2ccc3c(c2[nH]1)OCCO3,,CCO,O,,,val
US20140256756A1,CC(C)c1nsc(N2CCC(N3CC[C@H](NC(=O)OC(C)(C)C)C3=O)CC2)n1>>CC(C)c1nsc(N2CCC(N3CC[C@H](N)C3=O)CC2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150133437A1,COC(=O)COc1ccc(Br)nc1[N+](=O)[O-]>>COC(=O)COc1ccc(Br)nc1N,[Fe],CO,,Cl,O=C([O-])O.[Na+],val
US20120101064A1,CC(C)(C)OC(=O)n1ccc2c(-c3cc(C(=O)c4nc5ccc(N6CCC(OP(=O)(OC(C)(C)C)OC(C)(C)C)CC6)nc5[nH]4)ccc3C#N)cncc21>>N#Cc1ccc(C(=O)c2nc3ccc(N4CCC(OP(=O)(O)O)CC4)nc3[nH]2)cc1-c1cncc2[nH]ccc12,,ClCCl,,C1COCCO1,Cl,val
US05194430,CCOP(=O)(CC(=O)C1CCCN(C(=O)OCc2ccccc2)C1C(=O)OCc1ccccc1)OCC>>O=C(CP(=O)(O)O)C1CCCNC1C(=O)O,,CC(C)O,,CCO,Cl,val
US20060106089A1,CC(C)(C)OC(=O)N1CCc2sc(S(=O)(=O)Cl)cc2C1.Nc1ccccc1NS(=O)(=O)c1cc2ccccc2s1>>CC(C)(C)OC(=O)N1CCc2sc(S(=O)(=O)Nc3ccccc3NS(=O)(=O)c3cc4ccccc4s3)cc2C1,,ClCCl,,c1ccncc1,,val
US20130296329A1,CC(C)(C)OC(=O)N1c2ccc(Cl)cc2CC1CO.CI>>COCC1Cc2cc(Cl)ccc2N1C(=O)OC(C)(C)C,,C1CCOC1,,O,[H-].[Na+],val
US20090264445A1,CCOC(=O)/C=C(\C)Oc1cccc(F)c1F.O=C1CCC(=O)N1Br>>CCOC(=O)/C=C(\CBr)Oc1cccc(F)c1F,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20100004280A1,CN(C)S(=O)(=O)n1cc(CC(C)(C)C)nc1C(=O)Cc1ccc(Br)cc1.c1cn[nH]c1>>CN(C)S(=O)(=O)n1cc(CC(C)(C)C)nc1C(=O)Cc1ccc(-n2cccn2)cc1,[Cu]I,Cc1ccccc1,,CN[C@@H]1CCCC[C@H]1NC,O=C([O-])[O-].[K+].[K+],val
US20110130380A1,COC(=O)[C@H]1C[C@@H](C(F)(F)F)CN(C(=O)OCc2ccccc2)C1>>O=C(O)[C@H]1C[C@@H](C(F)(F)F)CN(C(=O)OCc2ccccc2)C1,,CO,O,[Na+].[OH-],,val
US20110201733A1,CCCCO.CCP(=O)(O)CCCO>>CCCCOP(=O)(CC)CCCO,,Cc1ccccc1,,O,,val
US20130116430A1,CC(C)(C)O.O=C(O)c1cnc(-n2cccn2)c(F)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)Nc1cnc(-n2cccn2)c(F)c1,,Cc1ccccc1,O,CCN(CC)CC,,val
US20050245529A1,C/C(=C\c1ccc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)cc1)CO.CC1CCNCC1>>C/C(=C\c1ccc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)cc1)CN1CCC(C)CC1,,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US20090176778A1,Fc1ccc(C2CCNC2)cc1.O=C(O)c1nc2c(C(F)(F)F)cc(Br)cn2c1Cl>>O=C(c1nc2c(C(F)(F)F)cc(Br)cn2c1Cl)N1CCC(c2ccc(F)cc2)C1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130017194A1,CCOC(=O)Cc1cnc[nH]c1=O.O=P(Cl)(Cl)Cl>>CCOC(=O)Cc1cncnc1Cl,,O,,,,val
US20070093483A1,N#Cc1ccccc1N=C=S.NNC(=O)Cc1ccccc1>>N#Cc1ccccc1-n1c(Cc2ccccc2)n[nH]c1=S,,CC(C)O,,,,val
US20050043388A1,COC(=O)c1ccc(NC(=O)CCc2ccc3c(c2)OCO3)cc1.NN>>NNC(=O)c1ccc(NC(=O)CCc2ccc3c(c2)OCO3)cc1,,CCO,,O,,val
US20090247526A1,N#Cc1ccncc1O.O=[N+]([O-])c1ccnc(Cl)c1>>N#Cc1ccncc1Oc1ccnc(Cl)c1,,O,,CN(C)C=O,[H-].[Na+],val
US20120264734A1,COC(=O)c1cc(Br)cc(NC2CCOCC2)c1C.COCC=O>>COCCN(c1cc(Br)cc(C(=O)OC)c1C)C1CCOCC1,,CC(Cl)Cl,,CC(=O)O,O=C([O-])O.[Na+],val
US20070142443A1,COC(=O)CC(C)=O.NCc1ccccc1>>COC(=O)CC(C)NCc1ccccc1,,CO,,CC(=O)O,,val
US20120258953A1,CC(C)COC(=O)n1ccnc1-c1ccc(Br)cc1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC1(C)OB(c2ccc(-c3ncc[nH]3)cc2)OC1(C)C,,CS(C)=O,,CC(=O)[O-].[K+],,val
US20130184282A1,CC(=O)Cl.Cc1ccc(-c2nc3cc(CCO)[nH]c3nc2-c2ccc(C)cc2)cc1>>CC(=O)OCCc1cc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc2[nH]1,,C1CCOC1,,CCN(C(C)C)C(C)C,O,val
US20150111892A1,CC(C)(C)[Si](C)(C)OCc1c[nH]c(=O)[nH]c1=O.CCCCCCN=C=O>>CCCCCCNC(=O)n1cc(CO[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O,CN(C)c1ccncc1,,,,,val
US20060094843A1,CCCCCCBr.CCOC(=O)C1CCCC1=O>>CCCCCCC1(C(=O)OCC)CCCC1=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04725610,Cc1oc(-c2ccccc2)nc1COc1ccc(CC2SC(=N)NC2=O)cc1.O=S(=O)(O)O>>Cc1oc(-c2ccccc2)nc1COc1ccc(CC2SC(=O)NC2=O)cc1,,O,,C1COCCO1,,val
US20160229816A1,CC1(C)COB(c2cc(OC(F)F)cc(C3OCCO3)c2)OC1.OO>>Oc1cc(OC(F)F)cc(C2OCCO2)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20090137595A1,CNC(=O)c1cn2nc(I)ccc2n1.Nc1cccc(O)c1>>CNC(=O)c1cn2nc(Oc3cccc(N)c3)ccc2n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050272709A1,COC(=O)C1CCCN1CC(=O)NCC1=NN=C(N)C1=NNc1cccc(F)c1>>NC1=NN=C(CNC(=O)CN2CCCC2C(=O)O)C1=NNc1cccc(F)c1,,CCO,,[K+].[OH-],,val
US20150322060A1,CC(C)=C(F)CO.O=C1NC(=O)c2ccccc21>>CC(C)=C(F)CN1C(=O)c2ccccc2C1=O,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160235727A1,CCOC(=O)c1cc(C)n[nH]1>>Cc1cc(C(=O)O)[nH]n1,,C1CCOC1,O,[Li+].[OH-],,val
US20030229120A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.c1ccc2c(c1)[nH]c1ccc(-c3nn[nH]n3)cc12>>c1ccc(C(c2ccccc2)(c2ccccc2)n2nnc(-c3ccc4[nH]c5ccccc5c4c3)n2)cc1,,CN(C)C=O,,CCN(CC)CC,O,val
US20070117798A1,COC(=O)[C@H]1CCCC(=O)N1C(=O)OC(C)(C)C.Fc1cccc(F)n1>>COC(=O)[C@@H](CCCC(=O)c1ccc(F)nc1F)NC(=O)OC(C)(C)C,,C1CCOC1,CCOC(C)=O,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US06159904,CCn1nccc1O.Cc1c(C(=O)O)cc(Cl)c2c1C(=O)CCS2>>CCn1nccc1OC(=O)c1cc(Cl)c2c(c1C)C(=O)CCS2,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20040116694A1,COc1ccc(F)cc1C(C)(C)CC(O)(C=O)C(F)(F)F.NC(=O)c1ccc2c(N)cccc2n1>>COc1ccc(F)cc1C(C)(C)CC(O)(C=Nc1cccc2nc(C(N)=O)ccc12)C(F)(F)F,,Cc1ccccc1,,CC(=O)O,O,val
US20130072679A1,COC(=O)c1cncc(-c2ccc3c(n2)CCC(=O)N3C)c1>>CN1C(=O)CCc2nc(-c3cncc(CO)c3)ccc21,,CO,,[BH4-].[Na+],,val
US20120258952A1,COc1ccc(Cn2cc(Cn3nc(I)c4c([N+](=O)[O-])cccc43)cn2)cc1>>COc1ccc(Cn2cc(Cn3nc(I)c4c(N)cccc43)cn2)cc1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20150031648A1,BrBr.Cc1ccc(C#N)n1C>>Cc1c(Br)cc(C#N)n1C,,CC(=O)O,,O,,val
US20110263640A1,CN1C2CCC1CC(=O)C2.COc1ccc2sccc2c1>>COc1ccc2sc(C3=CC4CCC(C3)N4C)cc2c1,,CCOCC,,[Li]CCCC,,val
US05204341,CC(C)(C)C(=O)Cl.CCN(CC)c1ccc(S(=O)(=O)N2CC(O)CC2=O)cc1>>CN(C)c1ccc(S(=O)(=O)N2CC(OC(=O)C(C)(C)C)CC2=O)cc1,,CCOC(C)=O,ClCCl,C1CN2CCN1CC2,,val
US20040235892A1,COCCBr.N#Cc1c(I)ccc(O)c1F>>COCCOc1ccc(I)c(C#N)c1F,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20020052397A1,Cn1cc(C2=C(c3cccc([N+](=O)[O-])c3)C(=O)NC2=O)c2ccccc21>>Cn1cc(C2=C(c3cccc(N)c3)C(=O)NC2=O)c2ccccc21,,CC(C)=O,,[Na+].[OH-],,val
US20150025070A1,CC(C)(C)OC(=O)NCC1CC1.O=c1[nH]c(CCl)nc2c1COCC2>>CC(C)(C)OC(=O)N(Cc1nc2c(c(=O)[nH]1)COCC2)CC1CC1,,CN(C)C=O,,O,[H-].[Na+],val
US20110076292A1,Cc1ccccc1CC1CCCN1.Cc1nc(-c2cn3c(n2)-c2cnc(Cl)cc2OCC3)n(CC(F)(F)F)n1>>Cc1nc(-c2cn3c(n2)-c2cnc(N4CCCC4Cc4ccccc4C)cc2OCC3)n(CC(F)(F)F)n1,,CCN(CC)CC,,CN1CCCC1=O,,val
US20090247567A1,CNc1ccc(C(=O)O)cc1Cl.O=C(c1ncc[nH]1)c1ncc[nH]1>>CNc1ccc(C(=O)N(C)C)cc1Cl,,CCOC(C)=O,,CCN(CC)CC,,val
US20150291563A1,CC(C)(C)OC(=O)N1CC=C(c2ccc(C3CC(C(F)(F)C(F)(F)F)=NN3c3ccc(F)cc3F)s2)CC1.O=C(O)C(F)(F)F>>Fc1ccc(N2N=C(C(F)(F)C(F)(F)F)CC2c2ccc(C3=CCNCC3)s2)c(F)c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20090253687A1,Cc1nn(C)cc1-c1ccc(F)cc1.O=C1CCC(=O)N1Br>>Cc1nn(C)c(Br)c1-c1ccc(F)cc1,,CC#N,,,,val
US04226773,CC(=O)N1CCN=C1Nc1ccnn1-c1ccc(F)cc1>>Fc1ccc(-n2nccc2NC2=NCCN2)cc1,,CO,,Cl,,val
US20080132503A1,COC(=O)c1ccc2c(c1)CCCN2C(=O)OCc1cccnc1>>O=C(O)c1ccc2c(c1)CCCN2C(=O)OCc1cccnc1,,Cl,,,,val
US20050080124A1,COc1ccc([N+](=O)[O-])cc1-c1c(Cl)cnn1C>>COc1ccc(N)cc1-c1c(Cl)cnn1C,,CCO,,,,val
US20100311798A1,CC(O)[C@@H](CCc1ccccc1)NC(=O)OC(C)(C)C>>C[C@@H](O)C(N)CCc1ccccc1,,C1COCCO1,Cl,,,val
US20090105474A1,CC(C)(C)OC(=O)c1ccc(-c2ccccc2)cc1Nc1ccc(-c2ccccc2)cc1>>O=C(O)c1ccc(-c2ccccc2)cc1Nc1ccc(-c2ccccc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140330009A1,Cn1cncc1C(=O)Cl.N#Cc1cccc(-c2nn(Cc3ccc(F)cc3F)c3c2CNCC3)c1>>Cn1cncc1C(=O)N1CCc2c(c(-c3cccc(C#N)c3)nn2Cc2ccc(F)cc2F)C1,,ClCCl,,CCN(CC)CC,Cl,val
US20070244132A1,N#Cc1cccc(Oc2ccc([N+](=O)[O-])cc2Cl)c1>>N#Cc1cccc(Oc2ccc(N)cc2Cl)c1,,CCO,O,[Ca+2].[Cl-].[Cl-],,val
US20050171109A1,COC(=O)c1ccc2c(N=CC(O)(CC(C)(C)c3cccc(F)c3OC)C(F)(F)F)cccc2n1>>COC(=O)c1ccc2c(NC3c4ccc(F)c(OC)c4C(C)(C)CC3(O)C(F)(F)F)cccc2n1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,O=C([O-])O.[Na+],,val
US20130079339A1,NCc1ccc(C(F)(F)F)nc1.Nc1cccc2c1OCC(=O)N2.O=C(n1ccnc1)n1ccnc1>>O=C1COc2c(cccc2NC(=O)NCc2ccc(C(F)(F)F)nc2)N1,,C1CCOC1,CN(C)C=O,,,val
US04627871,Cc1cc(C)nc(Oc2ccc([N+](=O)[O-])cc2)n1>>Cc1cc(C)nc(Oc2ccc(N)cc2)n1,[Ni],C1COCCO1,,[H][H],,val
US20100120751A1,c1ccc(CN2CCC3(CC2)OCCc2ccccc23)cc1>>c1ccc2c(c1)CCOC21CCNCC1,[Pd],CCO,,[H][H],,val
US20090264431A1,CC(C)(C)OC(=O)N1C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1COCc1ccccc1>>CC(C)(C)OC(=O)N1C[C@@H](O)C[C@@H]1COCc1ccccc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20060128712A1,CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O.Clc1ccc2sc(N3CCNCC3)nc2c1>>CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2nc3cc(Cl)ccc3s2)CC1,,C1CCOC1,,,,val
US04999378,CCOC(=O)C(C)=Cc1ccc([N+](=O)[O-])cc1>>CCOC(=O)C(C)=Cc1ccc(N)cc1,[Zn],CC(=O)O,,,,val
US20110190365A1,N#Cc1cc(-n2nc(C(F)(F)F)c(-c3cc(Cl)cc(C(F)(F)F)c3)c2N)ccc1F.c1nc[nH]n1>>N#Cc1cc(-n2nc(C(F)(F)F)c(-c3cc(Cl)cc(C(F)(F)F)c3)c2N)ccc1-n1cncn1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05571810,CS(=O)(=O)c1ccc(-c2cc(C(=O)O)sc2-c2ccc(F)cc2)cc1.ClP(Cl)(Cl)(Cl)Cl>>CS(=O)(=O)c1ccc(-c2cc(C(=O)Cl)sc2-c2ccc(F)cc2)cc1,,C1CCOC1,Cc1ccccc1,,,val
US05721245,Cn1cc(C2=C(c3c4n(c5ccccc35)CCC(CCN=[N+]=[N-])C4)C(=O)NC2=O)c2ccccc21>>Cn1cc(C2=C(c3c4n(c5ccccc35)CCC(CCN)C4)C(=O)NC2=O)c2ccccc21,[Pd],CO,,,,val
US20160083365A1,CC(C)(C)CNS(C)(=O)=O.Clc1ccnc(Cl)n1>>CC(C)(C)CN(c1ccnc(Cl)n1)S(C)(=O)=O,,CN(C)C=O,,[H-].[Na+],,val
US04262004,OC(CNC(=S)Nc1ccccc1)c1ccccc1>>c1ccc(C2CN=C3Sc4ccccc4N32)cc1,,ClC(Cl)(Cl)Cl,,BrBr,,val
US20050227932A1,CC(O)c1ccc(Cl)c(F)c1.O=C1NC(=O)c2ccccc21>>CC(c1ccc(Cl)c(F)c1)N1C(=O)c2ccccc2C1=O,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090143353A1,C=Cc1c(C)c(C#N)c2nc(C3CC3)oc2c1F.CN(C)[C@H]1CCNC1>>C=Cc1c(C)c(C#N)c2nc(C3CC3)oc2c1N1CC[C@H](N(C)C)C1,,CCOC(C)=O,CS(C)=O,CCN(CC)CC,O=C([O-])O.[Na+],val
US20100261698A1,CCCC(=O)Cl.Cn1c(-c2cncc(CN)c2)c(C#N)c2ccc(Cl)cc21>>CCCC(=O)NCc1cncc(-c2c(C#N)c3ccc(Cl)cc3n2C)c1,,ClCCl,,CCN(CC)CC,,val
US04920120,CCO.O=C(O)c1cn(C2CC2)c2nc(Cl)c(F)cc2c1=O>>CCOC(=O)c1cn(C2CC2)c2nc(Cl)c(F)cc2c1=O,,CCO,ClCCl,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20100233116A1,OCc1ccc(C(F)F)o1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=NCc1ccc(C(F)F)o1,,C1CCOC1,ClCCl,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070078121A1,CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2)n(-c2cccc(CO[Si](C)(C)C(C)(C)C)c2)n1>>NC(=O)Nc1cccc(Cl)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05696056,CC(=O)OC1COCC1OC(=O)C(C)Nc1cc(N)c(F)cc1Cl.O=C1OC(=O)c2ccccc21>>CC(=O)OC1COCC1OC(=O)C(C)Nc1cc(N2C(=O)c3ccccc3C2=O)c(F)cc1Cl,,O,,CC(=O)O,,val
US20090186897A1,O=C(O)Cc1cccc([N+](=O)[O-])c1.O=C1OC(=O)C2=C1CCCC2>>O=C1OC(=Cc2cccc([N+](=O)[O-])c2)C2=C1CCCC2,,CCO,,CC(=O)[O-].[Na+],,val
US20020065429A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCCCCCCCCCCCCCCCc1ccc(I)cc1>>Cc1ccc(S(=O)(=O)OCCCCCCCCCCCCCCCc2ccc(I)cc2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20110212918A1,CC(=O)OC(C)=O.Nc1cnc(SCc2ccccc2)c(Br)c1>>CC(=O)Nc1cnc(SCc2ccccc2)c(Br)c1,,C1CCOC1,,CCN(CC)CC,,val
US20090247502A1,COC(=O)c1cnc2c(c1)N(C(=O)OC(C)(C)C)CCO2>>CC(C)(C)OC(=O)N1CCOc2ncc(C(=O)O)cc21,,CO,O,[Li+].[OH-],,val
US20080269210A1,CC(C)(C)OC(=O)CC(C)(N)C(=O)O.NC(=NO)c1cc2nc(-c3cnc(N)nc3)nc(N3CCOCC3)c2s1>>CC(C)(N)c1nc(-c2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)no1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US04684656,COC(=O)C1=C(C)NC(SCc2ccc(OC)cc2)=NC1c1cccc([N+](=O)[O-])c1.CS(=O)(=O)Cl>>COC(=O)C1=C(C)N=C(SCc2ccc(OC)cc2)N(S(C)(=O)=O)C1c1cccc([N+](=O)[O-])c1,,ClCCl,,c1ccncc1,,val
US04501746,CCCCSCC(=O)O.c1cc(CCNC2CCCCC2)ccn1>>CCCCSCC(=O)N(CCc1ccncc1)C1CCCCC1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20140275015A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.c1cc2c(cn1)nnn2-c1ccn[nH]1>>CC(C)(C)OC(=O)n1ccc(-n2nnc3cnccc32)n1,,ClCCl,,,,val
US20150291593A1,Cc1ccc(S(=O)(=O)O[C@@H]2C[C@@H](c3nn4ccc(Cl)c4c(=O)n3-c3cccc(F)c3)N(C(=O)OC(C)(C)C)C2)cc1.[C-]#N>>CC(C)(C)OC(=O)N1C[C@@H](C#N)C[C@H]1c1nn2ccc(Cl)c2c(=O)n1-c1cccc(F)c1,,CS(C)=O,,O,,val
US05236937,CCC(=O)CC(=O)OC.CCC(N)=CC#N>>CCc1cc(N)c(C(=O)O)c(CC)n1,,CO,,[Na+].[OH-],,val
US04616014,CNN.CSc1nnc(-c2ccccc2)c(C)n1>>Cc1nc(N(C)N)nnc1-c1ccccc1,,CCO,,,,val
US06372764B1,CO.O=C(O)C1CN(C(=O)c2cccc3ccccc23)CC1CN1CCC(c2ccc(F)cc2)CC1>>COC(=O)C1CN(C(=O)c2cccc3ccccc23)CC1CN1CCC(c2ccc(F)cc2)CC1,,C1CCOC1,CO,C[Si](C)(C)C=[N+]=[N-],,val
US20090312352A1,CCNc1ccccc1.O=C(O)CN1C(=O)CSC1=S>>O=C(CN1C(=O)CSC1=S)NCCc1ccccc1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20070173507A1,CCOC(=O)CC(=O)CCCl.Nc1ccc(Br)cn1>>CCOC(=O)CCc1cn2cc(Br)ccc2n1,,CCO,,,,val
US05753664,Cn1c(=O)c2[nH]cnc2n(C)c1=O.O=C(c1ccc(F)cc1)c1ccc(CBr)cc1>>Cn1c(=O)c2c(ncn2Cc2ccc(C(=O)c3ccc(F)cc3)cc2)n(C)c1=O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20080004271A1,CO.O=C(O)c1ccc(C(F)(F)F)c(F)c1>>COc1cc(C=O)ccc1C(F)(F)F,,CO,CS(C)=O,Cl,C[O-].[Na+],val
US20110021493A1,CCOP(=O)(CC(=O)O)OCC.Fc1ccc(Nc2ncnc3sc4c(c23)CCNC4)cc1Cl>>CCOP(=O)(CC(=O)N1CCc2c(sc3ncnc(Nc4ccc(F)c(Cl)c4)c23)C1)OCC,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20140073627A1,COc1cc(C)c(S(=O)(=O)N(Cc2nc(C(=O)N3CCNCC3)co2)C2CC2)c(C)c1.Nc1ncccc1C=O>>COc1cc(C)c(S(=O)(=O)N(Cc2nc(C(=O)N3CCN(Cc4cccnc4N)CC3)co2)C2CC2)c(C)c1,,ClCCCl,,CC(=O)O,,val
US20150158847A1,COc1ccc(COc2ccc(CNc3ccc(Br)cc3[N+](=O)[O-])cc2OC)cc1>>COc1ccc(COc2ccc(CNc3ccc(Br)cc3N)cc2OC)cc1,[Fe],C1CCOC1,CCO,O,[Cl-].[NH4+],val
US20070244095A1,Cc1cc2c(cc1C(F)(F)F)N(Cc1ccc(C#N)cc1)CCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1.[N-]=[N+]=[N-]>>Cc1cc2c(cc1C(F)(F)F)N(Cc1ccc(-c3nnn[nH]3)cc1)CCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,Cl,val
US20060106071A1,CC(Oc1cc(C(F)(F)F)ccn1)C(=O)O.CO>>COC(=O)C(C)Oc1cc(C(F)(F)F)ccn1,,CO,ClCCl,C[Si](C)(C)C=[N+]=[N-],,val
US20110003807A1,C=CCB1OC(C)(C)C(C)(C)O1.COC(=O)c1sc(-c2c(C)nn3ccccc23)nc1OS(=O)(=O)C(F)(F)F>>C=CCc1nc(-c2c(C)nn3ccccc23)sc1C(=O)OC,,O,,COCCOC,O=C([O-])[O-].[Cs+].[Cs+],val
US20130029961A1,C[Si](C)(C)CCOCCl.O=C(Nc1ccc(F)cc1)c1ncc(Br)cn1>>C[Si](C)(C)CCOCN(C(=O)c1ncc(Br)cn1)c1ccc(F)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20050176796A1,COc1ccc(-n2nc(C(N)=O)c3ccc4[nH]ncc4c32)cc1>>COc1ccc(-n2nc(C#N)c3ccc4[nH]ncc4c32)cc1,,C1CCOC1,O,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US06627651B1,O=C([O-])C1=Cc2cc(OCc3ccc(F)cc3F)ccc2CCC1>>O=C(O)C1=Cc2cc(OCc3ccc(F)cc3F)ccc2CCC1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20100331314A1,CC(C)(C)c1cccc(N)c1.O=Cc1cnn2ccc(Cl)nc12>>CC(C)(C)c1cccc(Nc2ccn3ncc(C=O)c3n2)c1,,C1COCCO1,,,,val
US07019002B2,C1CNCCN1.Cc1nc(S(C)(=O)=O)nc2c1ccc(=O)n2-c1ccc(C(=O)NCc2ccccc2)cc1>>Cc1nc(N2CCNCC2)nc2c1ccc(=O)n2-c1ccc(C(=O)NCc2ccccc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20060063779A1,Cc1nc(Cl)ccc1C(=O)Nc1ccc(Cl)c(-c2ccccn2)c1.NCCc1c[nH]cn1>>Cc1nc(NCCc2c[nH]cn2)ccc1C(=O)Nc1ccc(Cl)c(-c2ccccn2)c1,,CCCCO,,,,val
US20120252817A1,CC(C)(C)OC(=O)NC1(C(=O)NC2(c3ncc(I)cn3)CC2)CC1.Cl.ClCCl>>Cl.Cl.NC1(C(=O)NC2(c3ncc(I)cn3)CC2)CC1,,ClCCl,,C1COCCO1,,val
US20100029704A1,CC(C(=O)O)c1ccc(CC2CCCC2=O)cc1.Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1>>CC(C(=O)O)c1ccc(CC2CCCC2=O)cc1.Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1,,CCOC(C)=O,,,,val
US06521643B1,Cc1ccnc(Oc2cccc([N+](=O)[O-])c2)c1>>Cc1ccnc(Oc2cccc(N)c2)c1,[Pd],CCO,,,,val
US20160060229A1,CC(C)(C)OC(=O)N(O)C1(Cc2ccc(Cl)cc2)C(=O)NC(=O)NC1=O>>O=C1NC(=O)C(Cc2ccc(Cl)cc2)(NO)C(=O)N1,,CCO,Cl,,,val
US20150018209A1,COc1c(C(=O)Nc2nnnn2C)ccc(C(F)(F)F)c1S(C)=NC#N.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COc1c(C(=O)Nc2nnnn2C)ccc(C(F)(F)F)c1S(C)(=O)=NC(=O)C(F)(F)F,,ClCCl,,O,,val
US20100234365A1,CS(=O)(=O)OCCN1CC(c2cccc(C(F)(F)F)c2)N(c2ccc(Oc3ccc(Cl)cc3)cc2)C1=O.NCCO>>O=C1N(CCNCCO)CC(c2cccc(C(F)(F)F)c2)N1c1ccc(Oc2ccc(Cl)cc2)cc1,,C1CCOC1,,,,val
US07157487B2,COC(=O)c1ccc(OC[C@@H]2C[C@H](OC(C)=O)CN2C(=O)Cc2ccc3nc(Nc4ccccc4C)oc3c2)cc1>>Cc1ccccc1Nc1nc2ccc(CC(=O)N3C[C@@H](O)C[C@H]3COc3ccc(C(=O)O)cc3)cc2o1,,C1CCOC1,,[Na+].[OH-],,val
US20070023628A1,CC(C)N(CC(=O)OC(C)(C)C)C(C)C.Cl>>CC(C)N(CC(=O)O)C(C)C.Cl,,O,,,,val
US20050148624A1,O=C1OC(=O)c2cc(Cl)ccc21.c1ccccc1>>O=C(O)c1ccc(Cl)cc1C(=O)c1ccccc1,,CCOC(C)=O,c1ccccc1,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US04859693,Brc1ccc(Br)cc1.O=C(CCl)c1ccc(F)cc1>>Fc1ccc(C2(c3ccc(Br)cc3)CO2)cc1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US04008249,O=C=Nc1ccccc1.c1ccc(Sc2cc(-c3ccccc3)n[nH]2)cc1>>O=C(Nc1ccccc1)n1nc(-c2ccccc2)cc1Sc1ccccc1,,Cc1ccccc1,,,,val
US20110224188A1,COC(=O)C(=NO)c1ccccn1>>COC(=O)C(N)c1ccccn1,,CCO,,,,val
US20150225397A1,C=CC(=O)CC.O=C1CCCC(=O)C1Cc1ccccc1>>CC(=O)CCC1(Cc2ccccc2)C(=O)CCCC1=O,,CC#N,,CCN(CC)CC,,val
US20100298298A1,COc1ccc(Cn2c(=O)c3cc(O)ccc3n(C3CCN(C=O)CC3)c2=O)cc1OC.N#CCBr>>COc1ccc(Cn2c(=O)c3cc(OCC#N)ccc3n(C3CCN(C=O)CC3)c2=O)cc1OC,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05929097,CI.COC(=O)c1cccc(CO)c1N(Cc1cccnc1)S(=O)(=O)c1ccc(OC)cc1>>COCc1cccc(C(=O)OC)c1N(Cc1cccnc1)S(=O)(=O)c1ccc(OC)cc1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20130345419A1,CC(C)(C)OC(=O)N1CCC[C@H]1C=C(Br)Br.COc1ccc(OCC(=O)N(C)OC)cc1OC>>COc1ccc(OCC(=O)C#C[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1OC,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20030045540A1,Brc1cscc1Br.CN(C)C=O.N#C[Cu]>>N#Cc1cscc1C#N,,Cl,,,,val
US20150001472A1,CC(C)Cc1cccc2ncccc12.O=C(OO)c1cccc(Cl)c1>>CC(C)Cc1cccc2c1ccc[n+]2[O-],,ClCCl,,,,val
US20060167052A1,Nc1ccc2c(c1)CCO2.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1ccc2c(c1)CCO2)C(F)(F)F,,ClCCl,,CCN(CC)CC,O,val
US05990151,COc1ccc(CC(CCC(C)C)NC(=O)OC(C)(C)C)cc1OCCc1ccccc1>>COc1ccc(CC(N)CCC(C)C)cc1OCCc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20040077557A1,COC(=O)CBr.c1cncc(-c2c[nH]cn2)c1>>COC(=O)Cn1cnc(-c2cccnc2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20140100231A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=c1ccc(CO)nn1C1CCCCO1>>Cc1ccc(S(=O)(=O)OCc2ccc(=O)n(C3CCCCO3)n2)cc1,,ClCCl,O,CCN(CC)CC,,val
US20130252944A1,COc1ccc(Cn2cc3c(n2)CC(C)Cc2sc(Nc4nccc(C)n4)nc2-3)cc1>>Cc1ccnc(Nc2nc3c(s2)CC(C)Cc2n[nH]cc2-3)n1,,O=C(O)C(F)(F)F,,,,val
US20130338367A1,O=C(CCCCl)Nc1cn(-c2cccnc2)nc1Cl>>O=C1CCCN1c1cn(-c2cccnc2)nc1Cl,,C1CCOC1,,O,[H-].[Na+],val
US20120208798A1,COC(=O)Cn1cc(-c2ccc3c(c2)[C@H](NC(=O)OC(C)C)C[C@H](C)N3C(C)=O)nn1>>CC(=O)N1c2ccc(-c3cn(CC(=O)O)nn3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C,,CO,,[Na+].[OH-],,val
US20050014755A1,NN.Nc1nnc(Cc2ccc(O)cc2)o1>>Nc1nnc(Cc2ccc(O)cc2)n1N,,O,,,,val
US20040259957A1,CCCCOc1ccc(C=O)cc1.COc1cc(OC)cc(C(C)=O)c1>>CCCCOc1ccc(/C=C/C(=O)c2cc(OC)cc(OC)c2)cc1,,CO,,[Na+].[OH-],,val
US20140051706A1,CCCCCCCCCCCC(=O)Cl.C[C@H]1C2N(C(=O)CN(C)N2C(=O)NCc2ccccc2)[C@@H](Cc2ccc(O)cc2)C(=O)N1Cc1cccc2cccnc12>>CCCCCCCCCCCC(=O)Oc1ccc(C[C@H]2C(=O)N(Cc3cccc4cccnc34)[C@@H](C)C3N2C(=O)CN(C)N3C(=O)NCc2ccccc2)cc1,,CCOC(C)=O,,C1CCOC1,CCN(CC)CC,val
US20100216750A1,O=C(O)CCOCCCc1ccccc1.c1ccc(-c2cnco2)nc1>>O=C(CCOCCCc1ccccc1)c1ncc(-c2ccccn2)o1,,CO,ClCCl,,,val
US20050069522A1,CCOC(=O)CBr.Cc1cnc(CNC(=S)Nc2ccc(N3CCOCC3)cc2)cn1>>Cc1cnc(CN2C(=O)CSC2=Nc2ccc(N3CCOCC3)cc2)cn1,,CCO,,CC(=O)[O-].[Na+],,val
US20150307480A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCO.CCOC(C)=O.ClCCl.O=C1NC(=O)c2ccccc21>>Cc1cc(=O)c(CNC(=O)OC(C)(C)C)c(C)o1,,CCO,ClCCl,NN,O,val
US05482916,Clc1cccc(Cl)c1-c1nsnc1Cl.N>>Nc1nsnc1-c1c(Cl)cccc1Cl,[Cu],CO,,,,val
US20090169558A1,COCCCl.O=c1[nH]cnc2[nH]c(-c3ccnc(Cl)c3)cc12>>COCCn1cnc2[nH]c(-c3ccnc(Cl)c3)cc2c1=O,,CN(C)C=O,,[H-].[Na+],,val
US04190596,CCCCC(=O)Cl.C[Si](C)(C)C#C[Si](C)(C)C>>CCCCC(=O)C#C[Si](C)(C)C,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US03972880,CC(CCN1CCCCC1)C(=O)O.CCCCCC(C)C(C)c1cc(O)c2c(c1)OC(C)(C)C1=C2C(C)CCS1.Cl>>CCCCCC(C)C(C)c1cc(OC(=O)C(C)CCN2CCCCC2)c2c(c1)OC(C)(C)C1=C2C(C)CCS1.Cl,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05914328,CC(C)(C)OC(=O)N1CC[C@H]1CO.Cc1ccc(O)cn1>>Cc1ccc(OC[C@@H]2CCN2C(=O)OC(C)(C)C)cn1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(O)cc(COC)c21.COS(=O)(=O)OC>>CCOC(=O)CC1OB(O)c2cc(OC)cc(COC)c21,,CC(C)=O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20150119380A1,COC(C)(CBr)OC.Nc1ccc(Cl)nn1>>Cc1cn2nc(Cl)ccc2n1,,CC#N,,,,val
US20100125062A1,CC(C)(C)[Si](C)(C)OC1CC=C(c2cccnc2F)CC1>>OC1CC=C(c2cccnc2F)CC1,,ClCCl,,,,val
US20150065705A1,CC(C)(C)OC(=O)N1C[C@@H](N(Cc2ccccc2)Cc2ccccc2)[C@H](O)C1.CCN(CC)S(F)(F)F>>CC(C)(C)OC(=O)N1C[C@@H](N(Cc2ccccc2)Cc2ccccc2)[C@H](F)C1,,ClCCl,,,,val
US20130217680A1,COC=C1CCc2c1ccc(F)c2C#N>>N#Cc1c(F)ccc2c1CCC2C=O,,ClCCl,,BrB(Br)Br,,val
US20160244449A1,O=C(O)c1cccc(Br)c1F.O=C1CCC(=O)N1I>>O=C(O)c1cc(I)cc(Br)c1F,,O=S(=O)(O)O,,,,val
US20110237583A1,CCOC(=O)C1CCN(c2nccc3nc(NCc4ccccc4Cl)ncc23)CC1>>O=C(O)C1CCN(c2nccc3nc(NCc4ccccc4Cl)ncc23)CC1,,C1CCOC1,,[Na+].[OH-],,val
US20130072478A1,CC(C)(C)[Si](C)(C)Cl.OC1CC=C(COCc2ccccc2)C1>>CC(C)(C)[Si](C)(C)OC1CC=C(COCc2ccccc2)C1,,CN(C)C=O,,c1c[nH]cn1,,val
US20110224262A1,BrBr.CCOc1cc(-c2ccccc2)n[nH]1>>CCOc1[nH]nc(-c2ccccc2)c1Br,,ClCCl,,,,val
US20150355456A1,CCCCCCCCCCCCCC(C)=O.Nc1cccc2cccc(N)c12>>CCCCCCCCCCCCCC1(C)Nc2cccc3cccc(c23)N1,,CC(C)O,,Cl,,val
US20130345397A1,C=O.CCOC(C)=O.O=[N+]([O-])c1cccc(O)c1>>O=[N+]([O-])c1cccc2c1COCO2,,O,,Cl,,val
US20080085890A1,CN1CCN(c2ccc([N+](=O)[O-])c(O)n2)CC1>>CN1CCN(c2ccc(N)c(O)n2)CC1,,CCO,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20080132507A1,CCOc1cc(C(Nc2ccc(C(=N)N)cc2)C(=O)OC)ccc1OCC(=O)N(C)C.Cl>>CCOc1cc(C(Nc2ccc(C(=N)N)cc2)C(=O)O)ccc1OCC(=O)N(C)C.Cl,,CO,,[Na+].[OH-],,val
US20060094767A1,C[C@](O)(CO)Cn1cc([N+](=O)[O-])nc1Cl.O=C(Cl)N1CCC(Nc2ccc(C(F)(F)F)cc2)CC1>>C[C@](O)(COC(=O)N1CCC(Nc2ccc(C(F)(F)F)cc2)CC1)Cn1cc([N+](=O)[O-])nc1Cl,CN(C)c1ccncc1,CCOC(C)=O,Cc1ccccc1,CCN(C(C)C)C(C)C,,val
US20140303171A1,CC(C)CCNC(CO[Si](C)(C)C(C)(C)C)c1cc(Br)cs1.O=S(=O)(Cl)c1ccccc1>>CC(C)CCN(C(CO[Si](C)(C)C(C)(C)C)c1cc(Br)cs1)S(=O)(=O)c1ccccc1,CN(C)c1ccncc1,c1ccncc1,,Cc1ccccc1,,val
US20070225280A1,CCOC(=O)C(=CN(C)C)C(=O)C(F)(F)F.NNC1CCCCC1>>CCOC(=O)c1cnn(C2CCCCC2)c1C(F)(F)F,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20070265303A1,CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCCCOc2ccc(CCNC(=O)OC(C)(C)C)cc2)ccc1O)C(C)C.Cl.ClCCl>>CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCCCOc2ccc(CCN)cc2)ccc1O)C(C)C.Cl.Cl,,CCOCC,ClCCl,CCO,,val
US05981525,COc1ccc2[nH]c(C=O)cc2c1.O=CC=P(c1ccccc1)(c1ccccc1)c1ccccc1>>COc1ccc2[nH]c(/C=C/C=O)cc2c1,,Cc1ccccc1,,,,val
US20140018371A1,CS(=O)(=O)OCC1CCN(C(=O)OCc2ccccc2)CC1.OC1CCC2(CC1)OCCO2>>O=C(OCc1ccccc1)N1CCC(COC2CCC3(CC2)OCCO3)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US04992435,CC1(C)Oc2ccsc2C(N2CCCC2=O)C1O.O=[N+]([O-])O>>CC1(C)Oc2cc([N+](=O)[O-])sc2C(N2CCCC2=O)C1O,,CC(=O)O,,[Br-].[K+],,val
US20160046605A1,CC(C)(C)OC(=O)NC1CCNCC1.O=[N+]([O-])c1ncccc1F>>CC(C)(C)OC(=O)NC1CCN(c2cccnc2[N+](=O)[O-])CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20160244438A1,CC1=C(C(=O)O[C@H](C)C(=O)OC(C)C)[C@@H](c2ccc(F)cc2Br)N=C(c2nccs2)N1.O=C1CCC(=O)N1Br>>CC(C)OC(=O)[C@@H](C)OC(=O)C1=C(CBr)NC(c2nccs2)=N[C@@H]1c1ccc(F)cc1Br,,ClCCl,,,,val
US20100075948A1,C=CC(C)(C)CC1NC(C(=O)OC(C)(C)C)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.O=C(O)C(F)(F)F>>C=CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20040136906A1,N.O=C(O)c1ccc(CBr)c([N+](=O)[O-])c1>>NCc1ccc(C(=O)O)cc1[N+](=O)[O-],,CCO,,,,val
US20060116410A1,N#Cc1ccc(CNC(=O)c2cccc(Cl)c2)c([N+](=O)[O-])c1>>N#Cc1ccc(CNC(=O)c2cccc(Cl)c2)c(N)c1,[Zn],CC(=O)O,,,,val
US20070100141A1,CCN(CC)C(=O)C(c1ccccc1)N1CCN(c2ccc(CN3C(=O)c4ccccc4C3=O)cc2F)CC1.CCO>>CCC(CC)C(=O)NCc1ccc(N2CCN(C(C(=O)N(CC)CC)c3ccccc3)CC2)c(F)c1,,CCO,,NN,,val
US20150065464A1,O=C(NC1CCC(=Cc2cccc([N+](=O)[O-])c2)CC1)c1cccnc1>>Nc1cccc(C=C2CCC(NC(=O)c3cccnc3)CC2)c1,[Fe],CC(=O)O,,,,val
US20100168418A1,COc1ccc2c(C)cc(=O)n(CCN3CCC(N(CC(=O)Nc4ccccn4)C(=O)OC(C)(C)C)CC3)c2c1>>COc1ccc2c(C)cc(=O)n(CCN3CCC(NCC(=O)Nc4ccccn4)CC3)c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140142083A1,COC(=O)c1nc(Cl)cc(N(C)C2CCOCC2)c1Br>>CN(c1cc(Cl)nc(C(=O)O)c1Br)C1CCOCC1,,C1CCOC1,,[Na+].[OH-],,val
US20090209607A1,CCCn1nccc1B1OC(C)(C)C(C)(C)O1.COC(=O)c1cc(Br)cs1>>CCCn1nccc1-c1csc(C(=O)OC)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20090186920A1,COC(=O)CBr.COc1cccc(S(=O)(=O)Nc2ccc(Cl)cc2)c1>>COC(=O)CN(c1ccc(Cl)cc1)S(=O)(=O)c1cccc(OC)c1,,C1CCOC1,,[H-].[Na+],,val
US20020156077A1,ClCCN1CCCCC1.Oc1ccc(Br)cc1>>Brc1ccc(OCCN2CCCCC2)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060122181A1,CCC(CC)c1ccc(N(Cc2ccc(-c3csc(CO)n3)cc2)C(C)C)cc1.O=S(Cl)Cl>>CCC(CC)c1ccc(N(Cc2ccc(-c3csc(CCl)n3)cc2)C(C)C)cc1.Cl,,ClC(Cl)Cl,,CN(C)C=O,,val
US20160016937A1,CN(CCO)C(=O)c1ccc2c(c1)N(c1ncc(B3OC(C)(C)C(C)(C)O3)cn1)CC21CC1.COc1cc(Cl)cc(Br)n1>>COc1cc(Cl)cc(-c2cnc(N3CC4(CC4)c4ccc(C(=O)N(C)CCO)cc43)nc2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20160120850A1,COC(=O)C(C)(C)CC(=O)O.C[Si](C)(C)CCOCOCc1csc(C(N)=NO)n1>>COC(=O)C(C)(C)CC(=O)ON=C(N)c1nc(COCOCC[Si](C)(C)C)cs1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050261276A1,CC(C)(C)OC(=O)N1CCC(C=O)CC1.Fc1ccc(F)c(Br)c1>>CC(C)(C)OC(=O)N1CCC(C(O)c2cc(F)ccc2F)CC1,,C1CCOC1,C1CCOC1,[Li]CCCC,,val
US04328341,CC(=O)Nc1cc(O)c(C(C)=O)cc1C(C)=O>>CC(=O)c1cc(C(C)=O)c(O)cc1N,,CCO,,Cl,,val
US20140315889A1,C=C1C(=O)c2c(n(Cc3ccc(C(=O)OC)cc3)c3ccc(F)cc23)CC1(C)C.Cc1ncc[nH]1>>COC(=O)c1ccc(Cn2c3c(c4cc(F)ccc42)C(=O)C(Cn2ccnc2C)C(C)(C)C3)cc1,,Cc1ccccc1,,,,val
US20120214788A1,COC(=O)C1CC(c2cccc(C(F)(F)F)c2)CN(C(=O)Oc2ccc([N+](=O)[O-])cc2)C1.OC1CCNCC1>>COC(=O)C1CC(c2cccc(C(F)(F)F)c2)CN(C(=O)N2CCC(O)CC2)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04360525,CN1CCC(N(C(=O)c2cc(Cl)ccc2F)c2ccccc2[N+](=O)[O-])CC1>>CN1CCC(N(C(=O)c2cc(Cl)ccc2F)c2ccccc2N)CC1,[Ni],CCOC(C)=O,CO,,,val
US20080221132A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.NCCN>>NCCNC(c1ccccc1)(c1ccccc1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20130029964A1,BrCCOC1CCCCO1.CC(=O)Nc1ccc(-n2cnc3ccc(Cl)cc32)cc1>>CC(=O)N(CCOC1CCCCO1)c1ccc(-n2cnc3ccc(Cl)cc32)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20130261106A1,CC(C)Oc1cc(N2CCC3(CCCN3)C2)ccc1[N+](=O)[O-].CC=O>>CCN1CCCC12CCN(c1ccc([N+](=O)[O-])c(OC(C)C)c1)C2,,CCOCC,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05616586,CC(=O)c1ccccc1N.O=C(O)CC1CCc2cc(Br)cc3[nH]c(=O)c(=O)n1c23>>CC(=O)c1ccccc1NC(=O)CC1CCc2cc(Br)cc3[nH]c(=O)c(=O)n1c23,,CC(=O)O,CCOC(C)=O,,,val
US20110112063A1,CC(=O)Cl.COc1ccc(C)c(N)c1>>COc1ccc(C)c(NC(C)=O)c1,,ClCCl,,CCN(CC)CC,,val
US20160185779A1,CC(Oc1ccccc1)C(=O)O.c1ccc(-c2n[nH]c3c2CNCC3)cc1>>CC(Oc1ccccc1)C(=O)N1CCc2[nH]nc(-c3ccccc3)c2C1,,ClCCl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120001127A1,CC1(C)c2cc(N(c3cccc(C4OCCO4)c3)c3cccc4ccccc34)ccc2-c2ccc(N(c3cccc(C4OCCO4)c3)c3cccc4ccccc34)cc21>>CC1(C)c2cc(N(c3cccc(C=O)c3)c3cccc4ccccc34)ccc2-c2ccc(N(c3cccc(C=O)c3)c3cccc4ccccc34)cc21,,CC(C)=O,,Cl,,val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.Sc1ccc2ccccc2n1>>COc1cc2nccc(Sc3ccc4ccccc4n3)c2cc1OC,,CC#N,,,,val
US20060128685A1,COc1cc[n+]([O-])cc1.C[Si](C)(C)C#N>>COc1ccnc(C#N)c1,,CC#N,,CCN(CC)CC,,val
US04289768,O=C(O)CCn1ccnc1.O=S1c2ccccc2Nc2cc(Cl)ccc21>>O=C(CCn1ccnc1)N1c2ccccc2S(=O)c2ccc(Cl)cc21,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060094733A1,CC(=O)OC(C)=O.Cn1c(=O)c2c(nc(-c3cccc(N)c3)n2Cc2c(F)cccc2Cl)n(C)c1=O>>CC(=O)Nc1cccc(-c2nc3c(c(=O)n(C)c(=O)n3C)n2Cc2c(F)cccc2Cl)c1,,ClCCl,,,,val
US20090186870A1,CC(C)(C)OC(=O)N1CCNCC1.NC(=O)c1cc(F)ccc1Cl>>CC(C)(C)OC(=O)N1CCN(c2ccc(Cl)c(C(N)=O)c2)CC1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US04622415,CC(Oc1cccc(Oc2c(Cl)cc(C(F)(F)F)cc2Cl)c1)C(=O)O.CCOC(=O)CBr>>CCOC(=O)COC(=O)C(C)Oc1cccc(Oc2c(Cl)cc(C(F)(F)F)cc2Cl)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US06211234B1,COC(=O)c1cc(-c2ccc(OCc3cccnc3)cc2O[C@H](CCC(=O)O)c2ccccc2C)n[nH]1.N>>Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cccnc2)ccc1-c1cc(C(N)=O)[nH]n1,,CO,,,,val
US20100069287A1,Cc1cccc(/C=C/C(=O)O)c1>>CC1CCCC(CCC(=O)O)C1,,CC(=O)O,,,,val
US04444584,CNc1ccc(OS(=O)(=O)O)cc1.Clc1ccc2nc(Cl)ccc2c1>>CN(c1ccc(O)cc1)c1ccc2cc(Cl)ccc2n1,,O,,CCO,,val
US20160185814A1,O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Au].[Na+].[Na+].[Na+]>>O.O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Au].[Na+].[Na+].[Na+],,O,,,,val
US06191130B1,BrBr.Cn1ncc(=O)n(C)c1=O>>Cn1nc(Br)c(=O)n(C)c1=O,,O,,,,val
US20130296301A1,CC(C)(C)[Si](C)(C)Cl.CCCN(C(=O)OC(C)(C)C)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1>>CCCN(C(=O)OC(C)(C)C)C1=N[C@H]2[C@H](O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](O)[C@@H]2O)S1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20070060607A1,COc1ccc(CCl)cc1.Oc1cccc(O)c1>>COc1ccc(COc2cccc(O)c2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05199970,CC(Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1)C(=O)Cl.CCNCC>>CCN(CC)C(=O)C(C)Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1,,c1ccccc1,,CCN(CC)CC,,val
US20090186907A1,CC(C)=O.Nn1c(-c2c(F)cccc2F)c(Cl)nc(-n2cccn2)c1=O>>CC(C)=Nn1c(-c2c(F)cccc2F)c(Cl)nc(-n2cccn2)c1=O,,CCOCC,,Cl,,val
US20040048863A1,COC(=O)c1ccc(CC(=O)NNC(=O)c2cccc(-c3ncc(-c4ccc(OC)cc4)o3)c2)cc1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>COC(=O)c1ccc(Cc2nnc(-c3cccc(-c4ncc(-c5ccc(OC)cc5)o4)c3)s2)cc1,,C1COCCO1,,O,,val
US20090275570A1,CI.C[C@H]1[C@H](NC(=O)OC(C)(C)C)CCCN1C(=O)OCc1ccccc1>>C[C@H]1[C@H](N(C)C(=O)OC(C)(C)C)CCCN1C(=O)OCc1ccccc1,,C1CCOC1,ClCCl,CO,[H-].[Na+],val
US20070135477A1,COc1ccc(C(C)(C)C)cc1C(=O)Nc1c[nH]nc1C(=O)Nc1ccccc1N>>COc1ccc(C(C)(C)C)cc1C(=O)Nc1c[nH]nc1-c1nc2ccccc2[nH]1,,CC(=O)O,,,,val
US04439619,C=CCC(C(N)=O)(C(=O)OCC)C(F)F>>C=CCC(N)(C(=O)OCC)C(F)F,,O,,CC#N,,val
US20130289067A1,CC(C)(F)CN.COc1ccc(C[C@H](N=[N+]=[N-])[C@H]2CO2)cc1>>COc1ccc(C[C@H](N=[N+]=[N-])[C@H](O)CNCC(C)(C)F)cc1,,CC(C)O,,CCN(CC)CC,Cl,val
US20120289551A1,Cc1ccccc1CC(C)(O)c1ccnc(N)c1.O=C=NC(=O)c1ccccc1>>Cc1ccccc1CC(C)(O)c1ccnc(NC(N)=O)c1,,ClCCl,,CCO,O=C([O-])[O-].[K+].[K+],val
US20050154015A1,CN(C)c1cccc(O)c1.N#CCC#N.O=Cc1ccc2c(c1)OCO2>>CN(C)c1ccc2c(c1)OC(N)=C(C#N)C2c1ccc2c(c1)OCO2,,CCO,,C1CCNCC1,,val
US20070054887A1,CC(C)(O)CC=CC1(C2=CC[C@H]3[C@@H](O)CCC[C@@]23C)CC1>>CC(C)(O)CC=CC1(C2=CC[C@H]3C(=O)CCC[C@@]23C)CC1,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20090163488A1,CCOC(=O)N=C=S.Cc1cc(NC(=O)c2cc(C)nn2C)cc(Oc2ccc(N)nc2)c1>>CCOC(=O)NC(=S)Nc1ccc(Oc2cc(C)cc(NC(=O)c3cc(C)nn3C)c2)cn1,,CS(C)=O,O,,,val
US03940395,CN1CCNCC1.COc1ccc(-c2nc(Cl)cc(Cl)n2)cc1>>COc1ccc(-c2nc(Cl)cc(N3CCN(C)CC3)n2)cc1,,CCO,,,,val
US05292760,Cc1ccsc1C(Cc1ccccc1NCN1C(=O)CCC1=O)N(C)C=O>>CNc1ccccc1CC(c1sccc1C)N(C)C=O,,CS(C)=O,,[BH4-].[Na+],,val
US20150148313A1,COC[C@H](C)S(=O)(=O)c1ccc([N+](=O)[O-])cc1CN(C)C(=O)OCc1ccccc1>>CNCc1cc(N)ccc1S(=O)(=O)[C@@H](C)COC,[Pd],CO,,,,val
US20130158025A1,CCOC(=O)CC(=O)c1ccccc1.COc1ccc(-c2c(C)n[nH]c2N)cc1>>COc1ccc(-c2c(C)nn3c(-c4ccccc4)cc(=O)[nH]c23)cc1,,c1ccncc1,,,,val
US20160137636A1,CI.COc1ccc(CN(c2ccon2)S(=O)(=O)c2ccc3c(-c4cc(F)c(-c5cccc(Cl)c5)cc4OC)c[nH]c(=O)c3c2)cc1>>COc1ccc(CN(c2ccon2)S(=O)(=O)c2ccc3c(-c4cc(F)c(-c5cccc(Cl)c5)cc4OC)cn(C)c(=O)c3c2)cc1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130267700A1,CCN.N#Cc1cnc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1ccc(OCCO)cc1>>CCNc1nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c(-c2ccc(OCCO)cc2)c1C#N,,C1CCOC1,,O,,val
US20080175814A1,CC(=O)c1ccc(C(=O)O)cc1.Cl.N=C(N)NN>>C/C(=N\N=C(N)N)c1ccc(C(=O)O)cc1.Cl,,CCOC(C)=O,CO,O=C(O)O,,val
US20120295924A1,Cc1cc(C(N)=O)c(N)s1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cc2c(=O)[nH]c(=O)[nH]c2s1,,C1CCOC1,O,,,val
US20090149430A1,CC(C)C[C@H](NC(=N)c1ccc2c(c1)Nc1ccccc1S2)C(=O)N[C@H]1CCOC1O.[Cl-]>>CC(C)C[C@H](NC(=N)c1ccc2c(c1)Nc1ccccc1S2)C(=O)N[C@H]1CCOC1O.Cl,,O,,I,,val
US20080132542A1,FC(F)(F)c1ccccc1OC1CCNCC1.Nc1nnc(Br)s1>>Nc1nnc(N2CCC(Oc3ccccc3C(F)(F)F)CC2)s1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US05100654,CCOP(=O)(Cc1cc(C=O)ccc1O)OCC>>O=Cc1ccc(O)c(CP(=O)(O)O)c1,,Cl,,,,val
US20040147748A1,CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)O)cc1Cl.Nc1cnc(CC2OCCO2)cn1>>CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2cnc(CC3OCCO3)cn2)cc1Cl,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20070299072A1,C1CNC1.COc1ccc(CCN2C(=O)C3(CCNCC3)N(C)C2c2ccc(C3CC3)cc2)cc1.O=C(Cl)OC(Cl)(Cl)Cl>>COc1ccc(CCN2C(=O)C3(CCN(C(=O)N4CCC4)CC3)N(C)C2c2ccc(C3CC3)cc2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20130102637A1,N=C1SCCN1Cc1ccc(Cl)nc1.O=C(Cl)CBr>>O=C(CBr)/N=C1\SCCN1Cc1ccc(Cl)nc1,,CC#N,,CCN(CC)CC,,val
US20060009511A9,NCCc1c[nH]c2cc(C(F)(F)F)ccc12.O=C(O)C(=O)O>>NCCc1c[nH]c2cc(C(F)(F)F)ccc12.O=C(O)C(=O)O,,CC(C)=O,,CCOCC,,val
US04940710,C=O.CCCCCCCCCCCCOCC1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3CC)CCN1>>CCCCCCCCCCCCOCC1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3CC)CCN1C,,O=CO,,,,val
US20090247538A1,CC(C)(C)OC(=O)NC1CCN(c2ncnc3[nH]ncc23)CC1>>NC1CCN(c2ncnc3[nH]ncc23)CC1,,CCOCC,,Cl,,val
US20070244153A1,CC(C)[C@@H](CN)NC(=O)OC(C)(C)C.O=C(O)c1cc2ccccc2o1>>CC(C)[C@@H](CNC(=O)c1cc2ccccc2o1)NC(=O)OC(C)(C)C,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20080207728A1,CCOC(=O)C(Cc1c[nH]c2c(F)cc(F)cc12)(NC(C)=O)C(=O)OCC>>CC(=O)NC(Cc1c[nH]c2c(F)cc(F)cc12)(C(=O)O)C(=O)O,,O,,Cl,[Na+].[OH-],val
US20070281936A1,COC(=O)c1cc(Cl)nc(N)n1.OB(O)c1ccccc1>>Nc1nc(C(=O)O)cc(-c2ccccc2)n1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20040192688A1,CCCCCCCCN.ClCCOc1ccc2ccccc2c1>>CCCCCCCCNCCOc1ccc2ccccc2c1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100216788A1,CN(C(=O)c1cccc(Oc2ccc([N+](=O)[O-])cc2Cl)c1)C(C)(C)C>>CN(C(=O)c1cccc(Oc2ccc(N)cc2Cl)c1)C(C)(C)C,[Pt],CCOC(C)=O,,,,val
US20100137281A1,CCc1cc2c(=O)n(C(C)C(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1.O=C([O-])O.[NH3+]O>>CCc1cc2c(=O)n(C(C)C(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1,,ClC(Cl)Cl,,CS(C)=O,[Cl-].[Na+],val
US20050187261A1,COC(=O)c1cc2cc(O)ccc2o1.OCCN1CCCC1>>COC(=O)c1cc2cc(OCCN3CCCC3)ccc2o1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100324041A1,CC(C)N(C[C@@H](C(=O)N1CCN(c2c(Br)cnc3[nH]ccc23)CC1)c1ccc(Cl)cc1)C(=O)OC(C)(C)C.OB(O)c1cccnc1>>CC(C)N(C[C@@H](C(=O)N1CCN(c2c(-c3cccnc3)cnc3[nH]ccc23)CC1)c1ccc(Cl)cc1)C(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US04963566,C=CCN.O=C1CCN2C(=O)OCc3cccc1c32>>C=CCNC1CCN2C(=O)OCc3cccc1c32,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05639766,CCOC(=O)[C@@H]1CCCN(CCON=C2CCCCC2c2ccccc2)C1.Cl>>Cl.O=C(O)[C@@H]1CCCN(CCON=C2CCCCC2c2ccccc2)C1,,CCO,,[Na+].[OH-],,val
US20120214803A1,CS(=O)(=O)c1ccc(S(=O)(=O)Cl)c([N+](=O)[O-])c1.Nc1ccc(Cl)c2cccnc12>>CS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3cccnc23)c([N+](=O)[O-])c1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20040058930A1,C#CC(C)(C)C.CN(C)C=O.Cc1cnc2c(NCCNC(=O)OC(C)(C)C)nc3cc(Br)sc3n12>>C#CCCC(O)c1cc2nc(NCCNC(=O)OC(C)(C)C)c3ncc(C)n3c2s1,[Cu]I,,,CCN(CC)CC,,val
US20150246880A1,FC(F)(F)C1(c2cc(Cl)cc(Cl)c2)C=CN(Cc2ccccc2)C1>>FC(F)(F)C1(c2cc(Cl)cc(Cl)c2)CCN(Cc2ccccc2)C1,,C1CCOC1,,Cl,[BH4-].[Na+],val
US20100099681A1,CCc1ccccc1-n1nc(C)c(-c2ccc3nccnc3c2)c1Nc1ccc(OC)cc1C(=O)OC>>CCc1ccccc1-n1nc(C)c(-c2ccc3nccnc3c2)c1Nc1ccc(OC)cc1C(=O)O,,C1COCCO1,O,Cl,[Na+].[OH-],val
US05585394,O=[N+]([O-])c1ccc(Cl)cc1NC1CCN(Cc2ccccc2)CC1>>Nc1ccc(Cl)cc1NC1CCN(Cc2ccccc2)CC1,[Fe],CCO,O,Cl,O=C([O-])O.[Na+],val
US20110311474A1,CCC1CC(OC2CCOCC2)CC1c1nnc2cnc3c(ccn3S(=O)(=O)c3ccc(C)cc3)n12>>CC[C@@H]1C[C@H](OC2CCOCC2)C[C@@H]1c1nnc2cnc3[nH]ccc3n12,,C1COCCO1,,Cl,[Na+].[OH-],val
US20060135593A1,CCOC(=O)[C@H]1CCCN1C(=O)Sc1cccc(O[Si](C)(C)C(C)(C)C)c1>>CCOC(=O)[C@H]1CCCN1C(=O)Sc1cccc(O)c1,,C1CCOC1,,,,val
US04432769,Nc1cc(Cl)ccc1[N+](=O)[O-].OCC(O)CO>>Nc1cc(OCC(O)CO)ccc1[N+](=O)[O-],,O,,[Na+].[OH-],,val
US20130085128A1,COC(=O)C(C)=O.Cc1cc(N)n[nH]1.O=Cc1ccc(O)cc1>>COC(=O)c1cc(-c2ccc(O)cc2)nc2[nH]nc(C)c12,,CC(=O)O,CO,,,val
US20130115190A1,C=CCCC(C)C[C@@H](C)C(N=C(c1ccccc1)c1ccccc1)C(=O)OCC.Cl>>C=CCCC(C)C[C@@H](C)C(N)C(=O)OCC.Cl,,CCOCC,,,,val
US20120129890A1,CCOC(=O)CBr.COc1ccc2c(c1)cc(-c1ccccc1)n2Cc1cccc(O)c1>>CCOC(=O)COc1cccc(Cn2c(-c3ccccc3)cc3cc(OC)ccc32)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04136256,CC(C)(C)c1ccc(S(N)(=O)=O)cc1.CCCCCCCCCCCCCCCCNc1ccc(C(=O)Cl)cc1>>CCCCCCCCCCCCCCCCNc1ccc(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1,,c1ccncc1,,Cl,,val
US20110311458A1,C=CCOC(=O)c1cccc(NC(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)c1>>O=C(O)c1cccc(N[C@@H](C(=O)OC2CN3CCC2CC3)c2ccccc2)c1,,C1CCOC1,,C1CCNCC1,,val
US20160075720A1,C[C@@H](CN=[N+]=[N-])NC(=O)OC(C)(C)C>>C[C@H](CN)NC(=O)OC(C)(C)C,[Pd],CCOC(C)=O,,,,val
US20150080364A1,Cc1ccc(N2CCOCC2)c(CN2CCN(C(=O)OC(C)(C)C)CC2)c1>>Cc1ccc(N2CCOCC2)c(CN2CCNCC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140256700A1,COC(=O)c1ccc2c3c(C(N)=O)cc(Br)cc3n(CC3CCOCC3)c2c1.Cc1noc(C)c1B(O)O>>COC(=O)c1ccc2c3c(C(N)=O)cc(-c4c(C)noc4C)cc3n(CC3CCOCC3)c2c1,,C1CCOC1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20160096827A1,C=O.CC(=O)N1CC[C@H](Oc2ccc(-c3ncnc(Nc4ccc(C5CCNCC5)cc4)n3)cc2C#N)C(F)(F)C1>>CC(=O)N1CC[C@H](Oc2ccc(-c3ncnc(Nc4ccc(C5CCN(C)CC5)cc4)n3)cc2C#N)C(F)(F)C1,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04714774,CC(=O)OC(C)=O.CCCc1c(OCCCOc2ccc(C(=O)OCCCN(C)C)cc2Br)ccc(C(C)=O)c1O>>CCCc1c(OCCCOc2ccc(C(=O)OCCCN(C)C)cc2Br)ccc(C(C)=O)c1OC(C)=O,,c1ccncc1,,,,val
US06326386B1,CC(C(=O)O)N(C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1)C1CCC1.CC(C)(C)N>>CC(C)(C)NC(=O)CCN(C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1)C1CCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150218096A1,COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C(N)=O)ccc23)c(F)c1.COC(OC)N(C)C>>COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C(=O)/N=C/N(C)C)ccc23)c(F)c1,,CCOC(C)=O,,,,val
US20110118261A1,Brc1ccc(N2CCC(N3CCCC3)C2)nc1.O=c1cc(OCc2ccc(Cl)cn2)cc[nH]1>>O=c1cc(OCc2ccc(Cl)cn2)ccn1-c1ccc(N2CCC(N3CCCC3)C2)nc1,[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=C([O-])[O-].[K+].[K+],val
US20100184802A1,C[C@H](C(=O)NC1CC1)n1ccc2c(N)cccc2c1=O.O=C(O)CC12CC3CC(CC(C3)C1)C2>>C[C@H](C(=O)NC1CC1)n1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2c1=O,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US04120856,CCN(CC)S(F)(F)F.O=C1Nc2ccc(Br)cc2C(c2ccccc2F)=NC1O>>O=C1Nc2ccc(Br)cc2C(c2ccccc2F)=NC1F,,ClCCl,,,,val
US20150099781A1,C#CC(C)O.Oc1cccc2ccccc12>>C#CC(C)Oc1cccc2ccccc12,,ClCCl,O,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090018103A1,Cc1ccc(S(=O)(=O)O[C@@H]2CCN(C(=O)OCc3ccccc3)C[C@H]2N=[N+]=[N-])cc1>>Cc1ccc(S(=O)(=O)O[C@@H]2CCN(C(=O)OCc3ccccc3)C[C@H]2N)cc1,,CO,,[BH4-].[Na+],,val
US06043248,ClCc1cc(Cl)ccn1.Nc1cc(Cl)[nH]c(=S)n1>>Nc1cc(Cl)nc(SCc2cc(Cl)ccn2)n1,,CCO,,[Na+].[OH-],,val
US20090018103A1,CN(C[C@H](CC1CCCCC1)NC(=S)NC#N)C(=O)OCC[Si](C)(C)C.COCCCC[C@@](O)(c1cccc(Cl)c1)[C@@H]1CCCNC1>>COCCCC[C@@](O)(c1ccccc1)[C@@H]1CCCN(C(=NC#N)N[C@@H](CC2CCCCC2)CN(C)C(=O)OCC[Si](C)(C)C)C1,,CCOCC,CN(C)C=O,ClCCCl,,val
US20070173530A1,COC(=O)COc1ccc(C#N)cc1.[N-]=[N+]=[N-].[NH4+]>>COC(=O)COc1ccc(-c2nn[nH]n2)cc1,,CN(C)C=O,,O,[Cl-].[Na+],val
US20100305070A1,Cc1cc(=O)oc2cc(N=C=O)ccc12.OCc1ccc(OCc2cc3ccccc3o2)cc1>>Cc1cc(=O)oc2cc(NC(=O)OCc3ccc(OCc4cc5ccccc5o4)cc3)ccc12,,CN(C)C=O,,C,C[O-].[Na+],val
US20140213588A1,CC(N)CCCc1ccc(Cl)c(Cl)c1.O=C(Cl)OCc1ccccc1>>CC(CCCc1ccc(Cl)c(Cl)c1)NC(=O)OCc1ccccc1,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US03935213,CCOC(=O)N1CCN(C#N)CC1.COc1cc(C(=N)N)c(N)c(OC)c1OC>>CCOC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)c(OC)c3n2)CC1,,CCN(CC)CC,,CCO,Cl,val
US20020064794A1,CCOC(=O)C(C)C(C)=O.CCOC(=O)CCCCCBr>>CCOC(=O)CCCCCC(C)(C(C)=O)C(=O)OCC,,CCO,,C,C[O-].[Na+],val
US20080269193A1,CC1(C)CC(=O)c2c(C(F)(F)F)n[nH]c2C1.N#Cc1c(F)cc(Br)cc1N[C@H]1CCC[C@@H]1O>>CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3cc(F)c(C#N)c(N[C@H]4CCC[C@@H]4O)c3)c2C1,,C1COCCO1,,,,val
US20090325993A1,NC(=O)C(N)c1ccc(Cl)cc1.O=C1CCOCC1>>O=C1NC2(CCOCC2)NC1c1ccc(Cl)cc1,,CO,,,,val
US04786646,CC(CCCc1cccnc1)NC(=O)C(O)c1ccccc1>>C[C@H](N)CCCc1cccnc1,,Cl,,,,val
US20160002177A1,C[Si](C)(C)CCOCOc1cc(-c2ccccc2C(=O)c2ccccc2)cc2c(=O)n(COCC[Si](C)(C)C)cnc12>>O=C(c1ccccc1)c1ccccc1-c1cc(O)c2nc[nH]c(=O)c2c1,,O=CO,,O,,val
US20120264735A1,CC(C)(C)OC(=O)c1nn(-c2cn[nH]c2)ccc1=O.CC(C)I>>CC(C)n1cc(-n2ccc(=O)c(C(=O)OC(C)(C)C)n2)cn1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130005716A1,BrBr.CC(=O)c1cccc(C(=O)N(C)C)c1>>CN(C)C(=O)c1cccc(C(=O)CBr)c1,,ClCCl,,,,val
US20030171411A1,CCOC(=O)Cc1csc(NC(=O)C(CC2CCCCC2)Oc2ccc(OC)cc2)n1>>COc1ccc(OC(CC2CCCCC2)C(=O)Nc2nc(CC(=O)O)cs2)cc1,,CCO,,[Na+].[OH-],,val
US20070287701A1,CCOC(=O)[C@@H]1CN(Cc2ccccc2)C[C@@H]1C#N>>N#C[C@@H]1CN(Cc2ccccc2)C[C@@H]1C(=O)O,,CO,O,Cl,[K+].[OH-],val
US05380721,C=CC(=O)[O-].CCN(CC)S(=O)(=O)c1ccc(C)cc1>>CCN(CC)S(=O)(=O)c1ccc(CCC(=O)OC)cc1,[Pd],,,CCO,,val
US05049576,CC(C)CCNC(=O)c1ccc2[nH]ccc2c1.COC(=O)c1ccc(CBr)c(OC)c1>>COC(=O)c1ccc(Cc2c[nH]c3ccc(C(=O)NCCC(C)C)cc23)c(OC)c1,O=[Ag-],CCOC(C)=O,Cc1ccccc1,,,val
US20100010038A1,CC(=O)NCC[C@@H]1CCc2ccc3nn(C)cc3c21.O=C1CCC(=O)N1Cl>>CC(=O)NCC[C@@H]1CCc2ccc3nn(C)c(Cl)c3c21,,CC#N,,,,val
US20130217715A1,COCN(c1cccc(-c2n[nH]cc2-c2ccnc(NC(C)(C)C)c2)c1F)S(=O)(=O)c1cc(F)ccc1F.FCCI>>COCN(c1cccc(-c2nn(CCF)cc2-c2ccnc(NC(C)(C)C)c2)c1F)S(=O)(=O)c1cc(F)ccc1F,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],val
US06576656B1,CCN(CC)CCN1C(=O)C(O)(c2ccc3ccccc3c2)c2c1cc(I)cc2C(F)(F)F.CCO.O=C([O-])O>>CCOC(=O)c1cc2c(c(C(F)(F)F)c1)C(O)(c1ccc3ccccc3c1)C(=O)N2CCN(CC)CC,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,,CCN(CC)CC,,val
US04406908,CC(=O)OCCCBr.N#Cc1cc2cccc(O)c2oc1=O>>CC(=O)OCCCOc1cccc2cc(C#N)c(=O)oc12,,O,,CN(C)C=O,[H-].[Na+],val
US20150111885A1,C#CC1CC1.O=[N+]([O-])c1cc(I)c(O)c(I)c1>>O=[N+]([O-])c1cc(I)c2oc(C3CC3)cc2c1,,c1ccncc1,,O,,val
US20130023526A1,CC1(C)OB(/C=C/c2ccccc2)OC1(C)C.COc1ccc(CNC(=O)c2cc(Br)ccn2)cc1>>COc1ccc(CNC(=O)c2cc(/C=C/c3ccccc3)ccn2)cc1,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140179680A1,CC(C)[C@@H]1CC(C)(O)CN1C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CC(C)[C@@H]1CC(C)(O)CN1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20150005347A1,CCN=C=S.N=c1ccccn1Cc1ccc(Cl)nc1>>CCNC(=S)N=c1ccccn1Cc1ccc(Cl)nc1,,CC#N,,CCN(CC)CC,Cl,val
US20090186879A1,BrC(Br)(Br)Br.CCN(CC)c1cccc2nc(C(=O)c3ccc(Cl)cc3Cl)n(CCCO)c12>>CCN(CC)c1cccc2nc(C(=O)c3ccc(Cl)cc3Cl)n(CCCBr)c12,,CC#N,CCOC(C)=O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05616620,CC(=O)OC(C)=O.NC(=N[N+](=O)[O-])NCCC[C@@H](N)C(=O)NCc1ccc(O)cc1>>CC(=O)N[C@H](CCCNC(N)=N[N+](=O)[O-])C(=O)NCc1ccc(O)cc1,,CC(=O)O,,,,val
US20040242884A1,Cc1c(CCl)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12.OCCNCC(O)c1ccccc1>>Cc1c(CN(CCO)CC(O)c2ccccc2)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US04772600,Nc1ccccc1Cl.O=C(O)Cn1c(-c2ccc(Cl)cc2)nc2cccnc21>>O=C(Cn1c(-c2ccc(Cl)cc2)nc2cccnc21)Nc1ccccc1Cl,,CN(C)C=O,O,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20070099990A1,CC(C)c1ccc(C(O)C(=O)O)cc1.Cc1ccc(C)c(O)c1>>Cc1ccc(C)c2c1OC(=O)C2c1ccc(C(C)C)cc1,,CCCCCC,CCOC(C)=O,,,val
US20110137031A1,Cc1cc(Cl)n2c(C#N)cc(-c3c(C)cc(Br)cc3C)c2n1.NC(N)=S>>Cc1cc(S)n2c(C#N)cc(-c3c(C)cc(Br)cc3C)c2n1,,CCO,,[Na+].[OH-],,val
US05773467,COc1ccc(C(=O)O)c2cc(C(C)=O)oc12.O=C(Cl)C(=O)Cl>>COc1ccc(C(=O)Cl)c2cc(C(C)=O)oc12,CN(C)C=O,ClCCl,,,,val
US20140316089A1,CC(C)c1cccc(C(C)C)c1NCc1cccc(Br)n1.Cc1ccccc1NCc1ccccc1B1OC(C)(C)C(C)(C)O1>>Cc1ccccc1NCc1ccccc1-c1cccc(CNc2c(C(C)C)cccc2C(C)C)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],val
US04454338,CS(=O)(=O)Oc1ccc2cc(C(=N)N)ccc2c1.Cc1cccc(C(=O)O)c1>>CS(=O)(=O)O.Cc1cccc(C(=O)Oc2ccc3cc(N)ccc3c2)c1,,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20110003787A1,COC[C@H](C)Oc1cc(O[Si](C(C)C)(C(C)C)C(C)C)cc(-c2ccc(C(=O)O)[nH]2)c1.C[C@H](O)[C@@H](N)CO>>COC[C@H](C)Oc1cc(O[Si](C(C)C)(C(C)C)C(C)C)cc(-c2ccc(C(=O)N[C@@H](CO)[C@H](C)O)[nH]2)c1,,CO,,COc1nc(OC)nc([N+]2(C)CCOCC2)n1.[Cl-],,val
US06893650B1,CC(=O)Nc1cc(C)c(-n2c(C)ccc2C)cc1C>>Cc1cc(-n2c(C)ccc2C)c(C)cc1N,,CCO,,[Na+].[OH-],,val
US20130022629A1,Nc1ccncn1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>O=[N+]([O-])c1ccc(S(=O)(=O)Nc2ccncn2)cc1,,c1ccncc1,,,,val
US20140350002A1,Cn1c(=O)n(CC2CC2(F)F)c2ccc(C3=CC4CNCC4C3)nc21.O=C(O)c1ccon1>>Cn1c(=O)n(CC2CC2(F)F)c2ccc(C3=CC4CN(C(=O)c5ccon5)CC4C3)nc21,,CC#N,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06153768,COCOc1ccc(C2COc3cc(OCOC)ccc3C2(O)c2ccc(O)cc2)cc1.ClCCN1CCCCC1>>COCOc1ccc(C2COc3cc(OCOC)ccc3C2(O)c2ccc(OCCN3CCCCC3)cc2)cc1,,CC(C)=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20080096921A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1CCl.CC1(C)OB(c2ccc(O)cc2)OC1(C)C>>CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(B2OC(C)(C)C(C)(C)O2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130096118A1,COC(=O)c1ccc2c(c1)[nH]c1c(C#N)cnc(Cl)c12.Cc1c(B2OC(C)(C)C(C)(C)O2)cccc1-n1cnc2c(F)cccc2c1=O>>COC(=O)c1ccc2c(c1)[nH]c1c(C#N)cnc(-c3cccc(-n4cnc5c(F)cccc5c4=O)c3C)c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US04120871,CC1(C)c2cc(OS(C)(=O)=O)ccc2OC1O>>CC1(C)C(=O)OC2=C1CC(OS(C)(=O)=O)C=C2,,CC(=O)O,,O,,val
US04444868,COc1cc(C=O)ccc1O.Cc1ccc2ccccc2n1>>COc1cc(C=Cc2ccc3ccccc3n2)ccc1O,,CC(=O)OC(C)=O,,,,val
US20020103240A1,CCCNC1CCc2nc(N)sc2C1.CS(=O)(=O)O>>CCCNC1CCc2nc(N)sc2C1.CS(=O)(=O)O,,CC(C)O,,,,val
US20030069297A1,CC1(C)OB(c2cccc3[nH]ccc23)OC1(C)C.Fc1cccc(F)c1Br>>Fc1cccc(F)c1-c1cccc2[nH]ccc12,[Pd],CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20090036478A1,CC(C)(C)C(=O)OC1CC(O)C1.CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F>>CC(C)(C)C(=O)OC1CC(O[Si](C)(C)C(C)(C)C)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070219196A1,C1COCCN1.CCCc1nc2cnc3ccccc3c2n1CCCCCC(=O)O>>CCCc1nc2cnc3ccccc3c2n1CCCCCC(=O)N1CCOCC1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20100292222A1,Fc1cc(C2=CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)ccc1OCc1ccccc1>>Oc1ccc(C2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1F,[Pd],CCO,,O=C[O-].[NH4+],,val
US20120101100A1,CCNC(=O)Nc1cc(C(N)=O)c(-c2nc(-c3ncccn3)c(C(=O)OCC)s2)cn1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCNC(=O)Nc1cc(C(N)=S)c(-c2nc(-c3ncccn3)c(C(=O)OCC)s2)cn1,,C1CCOC1,,,,val
US20150065482A1,O=C1OC(c2cccc(Br)c2)=NC1C1=NCCCC1>>O=C(O)c1nc(-c2cccc(Br)c2)n2c1CCCC2,,CO,,O,[Li+].[OH-],val
US20150232465A1,C[C@@H](CO)Nc1ccc(Br)cc1N.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)Nc2cc(Br)ccc2N[C@@H](C)CO)cc1,,c1ccncc1,,,,val
US20150111877A1,CC(=O)COc1ncc([N+](=O)[O-])cc1[N+](=O)[O-]>>CC1COc2ncc(N)cc2N1,[Ni],CCOC(C)=O,,,,val
US20150232460A1,FC(F)(F)c1ccc(Cl)nc1.NC1CC(F)(F)CC1NC(=O)c1ccccc1-n1nccn1>>O=C(NC1CC(F)(F)CC1Nc1ccc(C(F)(F)F)cn1)c1ccccc1-n1nccn1,,CS(C)=O,,CCN(C(C)C)C(C)C,Cl,val
US04088538,O=C(CO)[C@@H](O)[C@H](O)[C@H](O)CO>>O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,,O,,,,val
US20030158195A1,COc1cccc(-c2cc3ncccc3c(Cl)n2)c1>>Oc1cccc(-c2cc3ncccc3c(Cl)n2)c1,,ClCCl,,BrB(Br)Br,,val
US05580872,CCOC(=O)c1ccc2cc(Cl)ccn2c1=O.CN1CCNCC1>>CCOC(=O)c1ccc2cc(N3CCN(C)CC3)ccn2c1=O,,c1ccncc1,,,,val
US20120316151A1,CC(C)(C)OC(=O)N1CC[C@@H](Cc2n[nH]c(=O)n2-c2ccc(-c3ccc4cccnc4c3)cc2)C1.Cl>>Cl.O=c1[nH]nc(C[C@@H]2CCNC2)n1-c1ccc(-c2ccc3cccnc3c2)cc1,,C1COCCO1,,,,val
US20070060566A1,Nc1ccc2c(c1)CCN(C1CCC1)CC2.O=C(Cl)c1ccc(Cl)nc1>>O=C(Nc1ccc2c(c1)CCN(C1CCC1)CC2)c1ccc(Cl)nc1,,C1CCOC1,CO,C1COCCN1,,val
US05468742,C#Cc1c(F)c(F)cc2c(=O)c(C(=O)OCC)cn(C3CC3)c12>>C#Cc1c(F)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,,CC(=O)O,,O,O=S(=O)(O)O,val
US05283251,COC(=O)CCCc1c(C)[nH]c2ccccc12>>Cc1[nH]c2ccccc2c1CCCC(=O)O,,CO,,[Na+].[OH-],,val
US20130303571A1,CC(=O)Cl.CNCc1ccc(Cl)c([N+](=O)[O-])c1>>CC(=O)NC(C)c1ccc(Cl)c([N+](=O)[O-])c1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20040054185A1,N#Cc1ccc(-c2ccc(O)cc2)cc1.O=C1CCC(=O)N1I>>N#Cc1ccc(-c2ccc(O)c(I)c2)cc1,,CC(=O)O,,O,O=S(=O)(O)O,val
US06369063B1,COC(=O)CN1CCN[C@@H](CCC(=N)NCNS(=O)(=O)c2ccc(C)cc2)C1=O.O=S(=O)(Cl)Cc1ccccc1>>COC(=O)CN1CCN(S(=O)(=O)Cc2ccccc2)[C@@H](CCC(=N)NCNS(=O)(=O)c2ccc(C)cc2)C1=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120134959A1,CNC.ClCc1cc(N2C3CCC2COC3)nc(Cl)n1>>CN(C)Cc1cc(N2C3CCC2COC3)nc(Cl)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06077853,COC(=O)c1ccc(C#N)c(OCc2ccccc2)c1>>N#Cc1ccc(CO)cc1OCc1ccccc1,,C1CCOC1,,[BH4-].[Li+],,val
US20080153817A1,CCCC1(CC(=O)[O-])CCCCC1=O.CCC[C@@H](c1ccc(C(F)(F)F)cc1)N(N)c1ccc(C(C)C)cc1.CCO>>CCCC(c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(C(C)C)ccc31)CCCC2(CCC)CC(=O)OC,Cl,,,,,val
US20080076924A1,N#Cc1c(F)cccc1F.O=C=Nc1ccc(Cl)cc1.c1ccc(C2CNCCN2)cc1>>N#Cc1c(F)cccc1N1CCN(C(=O)Nc2ccc(Cl)cc2)C(c2ccccc2)C1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080234268A1,CC(N)=O.Clc1nccc2c(Br)cccc12>>Nc1nccc2c(Br)cccc12,,O,,O=C([O-])[O-].[K+].[K+],,val
US20090186897A1,COC(=O)C(C)(C)NC(=O)Nc1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1>>CC1(C)NC(=O)N(c2cccc(Cc3n[nH]c(=O)c4c3CCCC4)c2)C1=O,,CN(C)C=O,,Cl,[Na+].[OH-],val
US05705531,C[C@]12CC[C@H](c3ccccc3)C[C@@]1(O)CC[C@@H]2C=O.N=C(N)NN>>C[C@]12CC[C@H](c3ccccc3)C[C@@]1(O)CC[C@@H]2/C=N/NC(=N)N,,C1COCCO1,Cl,O=C(O)O,,val
US06914074B2,COc1ccc(-c2ccc3cc(OC)ccc3c2)cc1.O=C1CCC(=O)N1Cl>>COc1ccc(-c2ccc3c(Cl)c(OC)ccc3c2)cc1,,CC#N,,,,val
US20080064687A1,CC(C)(C)c1ccc(CN)cc1.COC(=O)CCc1ccc(NS(C)(=O)=O)c(F)c1>>CC(C)(C)c1ccc(CNC(=O)CCc2ccc(NS(C)(=O)=O)c(F)c2)cc1,,Cc1ccccc1,,,,val
US20130143892A1,CCOC(=O)c1cc(Cl)on1.N#Cc1ccc(B(O)O)c(F)c1>>CCOC(=O)c1cc(-c2ccc(C#N)cc2F)on1,,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20030149084A1,CCOC(=O)C(Cc1ccccc1)C(=O)OCC>>O=C(O)C(Cc1ccccc1)C(=O)O,,CCO,O,[K+].[OH-],,val
US20040024010A1,CC(C)(C)c1cc(C=O)ccc1O.OCCN1CCOCC1>>CC(C)(C)c1cc(C=O)ccc1OCCN1CCOCC1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030149016A1,CCCC[Sn](Cl)(CCCC)CCCC.O=C(NCCS(=O)(=O)NCC(=O)c1ncn2ccsc12)OCc1ccc([N+](=O)[O-])cc1>>CCCC[Sn](CCCC)(CCCC)c1cn2cnc(C(=O)CNS(=O)(=O)CCNC(=O)OCc3ccc([N+](=O)[O-])cc3)c2s1,,C1CCOC1,CN(C)P(=O)(N(C)C)N(C)C,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US04627933,CCCCC[C@@H]1CC[C@@H](c2ccc(CC(=O)O)cc2)CC1.N#Cc1ccc(CO)cc1>>CCCCC[C@@H]1CC[C@@H](c2ccc(CC(=O)OCc3ccc(C#N)cc3)cc2)CC1,,Cc1ccccc1,,O=S(Cl)Cl,c1ccncc1,val
US20100004245A1,Brc1ccc(Br)nn1.OC1CCNCC1>>OC1CCN(c2ccc(Br)nn2)CC1,,CC(C)O,,,,val
US20160145218A1,C[C@H](N[S@@](=O)C(C)(C)C)c1ccc(OC(F)(F)F)cc1F.Cl>>C[C@H](N)c1ccc(OC(F)(F)F)cc1F.Cl,,CO,,,,val
US20040082781A1,CC(C)(C)O.CCc1nc2c(-c3ccc(C)cc3C)cc(C)nn2c1C(=O)O.[N-]=[N+]=Nc1[pH]cc(-c2ccccc2)c1-c1ccccc1>>CCc1nc2c(-c3ccc(C)cc3C)cc(C)nn2c1NC(=O)OC(C)(C)C,,Cc1ccccc1,,CCN(CC)CC,O,val
US20040171075A1,CC(C)(C)c1cc(N)n(-c2cccc(CC(N)=O)c2)n1.O=C=Nc1cccc2ccccc12>>CC(C)(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2cccc(CC(N)=O)c2)n1,,ClCCl,,,,val
US04032639,Nc1ccc(F)c([N+](=O)[O-])c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1ccc(F)c([N+](=O)[O-])c1)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US06057337,O=C([O-])CCCCl.OCCC1CCCCN1>>O=C(CCCCl)C1CCNC(CCO)C1,,CN(C)C=O,,On1nnc2ccccc21,,val
US20040097546A1,CCOC(=O)C1CCN(C(C)(C)C)CC1=O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)C1=C(OS(=O)(=O)C(F)(F)F)CN(C(C)(C)C)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05958910,NC(N)=S.O=C(CBr)c1cc(C(F)(F)F)ccc1F>>Br.Nc1nc(-c2cc(C(F)(F)F)ccc2F)cs1,,CO,,,,val
US20010021718A1,NO.O=C(O)C[C@@H](CCCC1CCCCC1)c1nc(CC(=O)N2CCCC2)no1.O=C(n1ccnc1)n1ccnc1>>N.O=C(C[C@@H](CCCC1CCCCC1)c1nc(CC(=O)N2CCCC2)no1)NO,,C1CCOC1,,Cl,,val
US20100010035A1,CCOC(=O)c1ccc2[nH]c(CC)cc(=O)c2c1.COCCOCN(c1noc(C)c1C)S(=O)(=O)c1sc(C)cc1-c1ccc(COS(C)(=O)=O)cc1COC>>CCOC(=O)c1ccc2nc(CC)cc(OCc3ccc(-c4cc(C)sc4S(=O)(=O)N(COCCOC)c4noc(C)c4C)c(COC)c3)c2c1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20090023763A1,Nc1ccc(-c2ccncc2)c(-c2cccc(F)c2)n1.O=C1CCC(=O)N1Br>>Nc1nc(-c2cccc(F)c2)c(-c2ccncc2)cc1Br,,CN(C)C=O,,O,,val
US20100022592A1,N#CCCl.Oc1ccc(Nc2nc(-c3ccccc3Cl)cs2)cc1>>N#CCOc1ccc(Nc2nc(-c3ccccc3Cl)cs2)cc1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070197512A1,COC(=O)/C=C\C(=O)[O-].O=C(Cl)C(=O)Cl>>COC(=O)/C=C\C(=O)Cl,CN(C)C=O,ClCCl,,,,val
US20150361098A1,NC(N)=O.Nc1c(Cl)cccc1C(=O)O>>Oc1nc(O)c2cccc(Cl)c2n1,,O,,,,val
US06110962,COC(=O)CBr.Oc1c(F)ccc(-c2c3ccccc3c(Br)c3sc4ccccc4c23)c1F>>COC(=O)COc1c(F)ccc(-c2c3ccccc3c(Br)c3sc4ccccc4c23)c1F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090170913A1,CN1CCC(CN(C)c2nc3cc(N)ccc3o2)C1.O=C(O)c1ccc(-c2ccc(Cl)cc2Cl)cc1>>CN1CCC(CN(C)c2nc3cc(NC(=O)c4ccc(-c5ccc(Cl)cc5Cl)cc4)ccc3o2)C1,,ClCCl,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20040198982A1,CC(C)(C)OC(=O)N1CCN(c2ccc(-c3nonc3NC(=O)OCC(Cl)(Cl)Cl)cc2)CC1.COC(=O)C(O)CC(C)C>>COC(=O)[C@H](CC(C)C)N(C(=O)OCC(Cl)(Cl)Cl)c1nonc1-c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)cc1,,CN(C)C=O,O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100004222A1,O=C(Nc1cnc2cc(CO)cnc2c1)OCc1ccccc1>>Nc1cnc2cc(CO)cnc2c1,[Pd],CO,,,,val
US20070275324A1,C=C(C)C(=O)Cl.OC1(C2CCCC2)CCCC1>>C=C(C)C(=O)OC1(C2CCCC2)CCCC1,,C1CCOC1,CCOCC,[Li]CCCC,O=C([O-])O.[Na+],val
US05451653,CC(C)(C)N.O=Cc1ccccc1>>CC(C)(C)N=Cc1ccccc1,,O,,,,val
US20100234395A1,C1CNCCN1.COc1ccc(-c2nc(Cl)oc2-c2ccc(OC)cc2)cc1>>COc1ccc(-c2nc(N3CCNCC3)oc2-c2ccc(OC)cc2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20100278835A1,Nc1cccc(F)c1CNC1CC1.O=C(n1ccnc1)n1ccnc1>>O=C1Nc2cccc(F)c2CN1C1CC1,,C1CCOC1,,,,val
US05929074,COc1ccc(CNOC=C=O)cc1N1CCN(C)CC1.O=c1[nH]ncc(Cl)c1Cl>>COc1ccc(CN(OC=C=O)c2cn[nH]c(=O)c2Cl)cc1N1CCN(C)CC1,,O,,CCN(CC)CC,CCO,val
US20110183960A1,NC(=O)C1(c2ccccc2)CCN(C(=O)c2cc(-c3ccc(Cl)cc3Cl)c(-c3ccc(O)cc3)s2)CC1.OCCCCl>>NC(=O)C1(c2ccccc2)CCN(C(=O)c2cc(-c3ccc(Cl)cc3Cl)c(-c3ccc(OCCCO)cc3)s2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100137599A1,COc1ccc2cc([C@H](C)C(=O)Cl)ccc2c1.O=[N+]([O-])OCCCCO>>COc1ccc2cc([C@H](C)C(=O)OCCCCO[N+](=O)[O-])ccc2c1,,ClCCl,,O,[K+].[OH-],val
US20120232056A1,CCNCC.COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(Cl)nc2c1>>CCN(CC)c1nc2cc(C(=O)OC)ccc2nc1-c1ccc(F)cc1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20140364410A1,CC(C)(Br)C=O.CCN1CCNCC1>>CCN1CCN(C(C)(C)C=O)CC1,,ClCCl,,Cl,[K+].[OH-],val
US20150011508A1,N#Cc1ccc(F)c(N)c1.NO>>N=C(NO)c1ccc(F)c(N)c1,,CCO,,,,val
US20150231132A1,CCOC(=O)CN1CCN(Cc2cccc(Oc3ccccc3)c2)CC1.NN>>NNC(=O)CN1CCN(Cc2cccc(Oc3ccccc3)c2)CC1,,CCO,,,,val
US20110269652A1,CCCCCCCCCCCCCCOCC(CO)(CO)COCCCCCCCCCCCCCC>>CCCCCCCCCCCCCCOCC(C=O)(C=O)COCCCCCCCCCCCCCC,,ClCCl,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US20030236412A1,CCOC(=O)c1c(C)nn(-c2ccccc2[N+](=O)[O-])c1C>>CCOC(=O)c1c(C)nn(-c2ccccc2N)c1C,[Pd],CCOC(C)=O,,CCO,[H][H],val
US20060009453A1,CN(C)CCCN(C)c1ccc(C(C)(C)C)cc1[N+](=O)[O-]>>CN(C)CCCN(C)c1ccc(C(C)(C)C)cc1N,[Pd],CO,,[H][H],,val
US20030171428A1,CI.COc1ccc(-c2cc3c(Br)c(OC)ccc3o2)cc1>>COc1ccc(-c2cc3c(C)c(OC)ccc3o2)cc1,,C1CCOC1,O,CN(C)CCN(C)C,[Li]CCCC,val
US20070244095A1,CI.Cc1ccc(F)c(C(=O)O)c1>>COC(=O)c1cc(C)ccc1F,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04486428,CC(CCCc1ccccc1)Oc1cc2c(c(OCc3ccccc3)c1)C(C(=O)Oc1ccc([N+](=O)[O-])cc1)CC(C)(C)C2.NC(N)=O>>CC(CCCc1ccccc1)Oc1cc(O)c2c(c1)CC(C)(C)CC2C(=O)NC(N)=O,,CS(C)=O,,[H-].[Na+],,val
US04711885,CC=C(C(=O)OCC)N1CCN(c2cccc(C(F)(F)F)c2)CC1>>CCOC(=O)C(CC)N1CCN(c2cccc(C(F)(F)F)c2)CC1,[Ni],CCO,,,,val
US20090281087A1,CN1CCC(O)CC1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CN1CCC(OC(=O)Oc2ccc([N+](=O)[O-])cc2)CC1,,ClCCl,,CN1CCOCC1,,val
US20140336412A1,CC(C)C[C@H](CN)CC(=O)O.O=C(O)[C@H](O)c1ccccc1>>CC(C)C[C@@H](CN)CC(=O)O.O=C(O)[C@H](O)c1ccccc1,,CC(C)O,,,,val
US20020037911A1,CCCc1cc(C2CCCCC2)ccc1OCCCOc1cccc(C(O)C(=O)OCC)c1.O=S(Cl)Cl>>CCCc1cc(C2CCCCC2)ccc1OCCCOc1cccc(C(Cl)C(=O)OCC)c1,,Cc1ccccc1,,c1ccncc1,,val
US05068325,NC(N)=S.O=C1CCN(CC#Cc2ccccc2)CCC1Br>>Nc1nc2c(s1)CCN(CC=Cc1ccccc1)CC2,,CCO,,Br,,val
US07071175B1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(N)ncc1Br>>Cc1cc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)ncc1Br,CN(C)c1ccncc1,ClC(Cl)Cl,,,,val
US04657708,CC(C)=O.O.O=Cc1cc(C=O)c(C#Cc2ccccc2)cc1C#Cc1ccccc1.O=S(=O)(O)O.[Cr+6].[O-2].[O-2].[O-2]>>O=C(O)c1cc(C(=O)O)c(C#Cc2ccccc2)cc1C#Cc1ccccc1.O=S(=O)(O)O.[Cr+6].[O-2].[O-2].[O-2],,CC(C)=O,O,,,val
US20110263559A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.Cc1nn(-c2ccccc2)c2nc(C3CCNCC3)[nH]c(=O)c12>>Cc1nn(-c2ccccc2)c2nc(C3CCN(C4CCN(C(=O)OC(C)(C)C)CC4)CC3)[nH]c(=O)c12,,CO,,Cl,[BH3-]C#N.[Na+],val
US20100064450A1,C1COCCN1.C=O.COc1cc(C=O)ccc1O>>COc1cc(C=O)cc(CN2CCOCC2)c1O,,CCO,,,,val
US20130310394A1,Cc1cc(N)ccc1C1CN=C2c3ccccc3NC(=O)N2C1.O=C=Nc1cc(C(F)(F)F)ccc1F>>Cc1cc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)ccc1C1CN=C2c3ccccc3NC(=O)N2C1,,ClCCl,,CCN(CC)CC,,val
US05569655,CCC(=O)c1ccoc1.ClCCl>>C=C(OCC)c1ccoc1,Cc1ccc(S(=O)(=O)O)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20160002221A1,CC(C)(C)C(=O)c1ccc(Br)cc1>>CC(C)(C)C(O)c1ccc(Br)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150166512A1,Cc1ccc(S(=O)(=O)/C=C/c2cc(Cl)ccc2C)cc1.[C-]#[N+]CC(=O)OCC>>CCOC(=O)c1[nH]ccc1-c1cc(Cl)ccc1C,,C1CCOC1,CCOC(C)=O,O,[H-].[Na+],val
US20060173010A1,Cc1nn(-c2nccc(-c3ccccn3)n2)c(C)c1Oc1ccc(CO)cc1>>Cc1nn(-c2nccc(-c3ccccn3)n2)c(C)c1Oc1ccc(C=O)cc1,,ClC(Cl)Cl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20040006245A1,C[Si](C)(C)C#Cc1ccc(Nc2c(C(=O)O)ccc(F)c2F)c(F)c1>>C#Cc1ccc(Nc2c(C(=O)O)ccc(F)c2F)c(F)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US04414389,C1=Cn2cccc2CN1CCc1ccncc1>>C1=Cn2cccc2CN1CCC1CCNCC1,O=[Pt]=O,CCO,,Cl,,val
US20120115811A1,Cc1cc(-c2cnc(OCC(=O)OC(C)(C)C)c([N+](=O)[O-])c2)ccn1>>Cc1cc(-c2cnc(OCC(=O)OC(C)(C)C)c(N)c2)ccn1,[Pd],,,,,val
US20070232645A1,O=C(Nc1ccc(Br)cc1)c1ccc(Cl)c([N+](=O)[O-])c1.Oc1ccc(S)cc1>>O=C(Nc1ccc(Br)cc1)c1ccc(Sc2ccc(O)cc2)c([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130072467A1,CC(C)(O)C#CCO.CS(=O)(=O)Cl>>CC(C)(O)C#CCOS(C)(=O)=O,,C1CCOC1,,CCN(CC)CC,O,val
US05559113,Clc1cnccn1.NCCc1c[nH]cn1>>c1cnc(NCCc2c[nH]cn2)cn1,,CC(C)O,,,,val
US20060205790A1,BrCCc1ccc2c(c1)O[C@H](COCc1ccccc1)CO2.C[Si](C)(C)CCOCOc1ccc([C@@H](O)CN)cc1NC=O>>C[Si](C)(C)CCOCOc1ccc([C@@H](O)CNCCc2ccc3c(c2)O[C@H](COCc2ccccc2)CO3)cc1NC=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20110230476A1,CC(C)(C)OC(=O)N1CCN(c2ccnc3ccc(CO)cc23)CC1>>CC(C)(C)OC(=O)N1CCN(c2ccnc3ccc(C=O)cc23)CC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20060019985A1,CC(C)(C)OC(=O)N1CCN(CC2CCNC2)CC1.CCOC(=O)c1cc(C2CC2)c2c(C)c(Cl)c(F)cn2c1=O>>CCOC(=O)c1cc(C2CC2)c2c(C)c(N3CCC(CN4CCN(C(=O)OC(C)(C)C)CC4)C3)c(F)cn2c1=O,,CC#N,,O=C([O-])O.[Na+],,val
US20130196998A1,CCCC[Sn](CCCC)(CCCC)c1ccc2c(c1)OCC21CCN(CCC(=O)OC(C)(C)C)CC1.O=C1CCC(=O)N1I>>CC(C)(C)OC(=O)CCN1CCC2(CC1)COc1cc(I)ccc12,,C1CCOC1,CCOC(C)=O,,,val
US06187924B1,BrCCOCCBr.CCOC(=O)CC(=O)OCC>>CCOC(=O)C1(C(=O)OCC)CCOCC1,,CCO,,C,C[O-].[Na+],val
US20040147543A1,CC(C)(C)OC(=O)NCc1ccc(CN)cc1.O=[N+]([O-])c1cnc2cc(Br)ccc2c1Cl>>CC(C)(C)OC(=O)NCc1ccc(CNc2c([N+](=O)[O-])cnc3cc(Br)ccc23)cc1,,ClCCl,,CCN(CC)CC,,val
US20050101644A1,CC(C)(C)OC(=O)NC1CCN(Cc2cc(Br)ccc2OCc2ccc(Cl)cc2)CC1>>NC1CCN(Cc2cc(Br)ccc2OCc2ccc(Cl)cc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120053173A1,O=S(Cl)Cl.OC(c1nn(-c2ccccc2)c2ccccc12)C1CCCCC1>>ClC(c1nn(-c2ccccc2)c2ccccc12)C1CCCCC1,,Cc1ccccc1,,c1ccncc1,O=C([O-])O.[Na+],val
US20110207702A1,Nc1ccc(Sc2ccc3c(c2)B(O)OC3)cc1.O=C(Cl)c1ccccc1>>O=C(Nc1ccc(Sc2ccc3c(c2)B(O)OC3)cc1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20030199552A1,O=C(O)c1cc2ccc3[nH]ccc3c2[nH]1.c1ccc(CC2CCNCC2)cc1>>O=C(c1cc2ccc3[nH]ccc3c2[nH]1)N1CCC(Cc2ccccc2)CC1,,CCOCC,,,,val
US04767779,CC1(C)Cc2ccccc2O1.O=[N+]([O-])O>>CC1(C)Cc2cc([N+](=O)[O-])ccc2O1,,O=S(=O)(O)O,,,,val
US20060142286A1,Cl[Mg]Cc1ccccc1.ON1CCCCC1>>ON1CCCCC1Cc1ccccc1,O=[Mn]=O,ClCCl,,[Cl-].[NH4+],,val
US20110201647A1,COCCn1ccc2c(OC(F)(F)F)ccc(F)c21.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COCCn1cc(C(=O)C(F)(F)F)c2c(OC(F)(F)F)ccc(F)c21,,CN(C)C=O,,,,val
US20100310512A1,CC(C)(C)OC(=O)CN.CCOC(=O)C1CCC(C=O)N1C(=O)OC(C)(C)C>>CCOC(=O)C1CCC(CNCC(=O)OC(C)(C)C)N1C(=O)OC(C)(C)C,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04970023,CCC(C)C(=O)Cl.CCC(C)C(=O)[O-].c1ccc(-c2ccccc2)cc1>>CCC(C)C(=O)[O-].CCC(C)C(=O)c1ccc(-c2ccccc2)cc1,,O=[N+]([O-])c1ccccc1,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20020032208A1,COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCN(C)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CNCCOc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC.Cl.O,,ClCCl,,Cc1ccccc1,,val
US20030166932A1,CCNc1ccc2c(c1)C(C(C)(C)C)=CCC2(C)C.O=C(O)c1ccc(F)nc1>>CCN(c1ccc2c(c1)C(C(C)(C)C)=CCC2(C)C)c1ccc(C(=O)O)cn1,,Cc1ccccc1,,CCOCC,,val
US07582626B2,COC(=O)[C@@H]1CCC[C@@H]1N(Cc1ccc(F)c(Cl)c1)C(=O)CC1=NS(=O)(=O)c2cc(NS(C)(=O)=O)ccc2N1>>CS(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(C1=C(O)[C@@H]3CCC[C@@H]3N(Cc3ccc(F)c(Cl)c3)C1=O)N2,,CCO,,C,C[O-].[Na+],val
US20130137865A1,Cn1ncc(-c2nc(-c3cccc(S(N)(=O)=O)c3)no2)c1COc1ccc(Br)cn1.N#C[Cu]>>Cn1ncc(-c2nc(-c3cccc(S(N)(=O)=O)c3)no2)c1COc1ccc(C#N)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US05574055,CC(C)(C)OC(=O)N1CCC(c2ccc(N)cc2)CC1.CCOC(=O)Cl>>CCOC(=O)Nc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2)cc1,,ClCCl,,c1ccncc1,,val
US20120214766A1,O=C(NC1CCSCC1)c1nn(-c2ccc(F)cc2F)c2c1C[C@H]1C[C@@H]21.O=C(OO)c1cccc(Cl)c1>>O=C(NC1CCS(=O)CC1)c1nn(-c2ccc(F)cc2F)c2c1C[C@H]1C[C@@H]21,,ClCCl,,,,val
US20100298290A1,Brc1cnc2nc[nH]c2c1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>Brc1cnc2c(c1)ncn2C(c1ccccc1)(c1ccccc1)c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20140296254A1,CCOc1c(Nc2ccc(Cl)c(S(=O)(=O)N3CCN(C)CC3)c2O)c(=O)c1=O.Cc1ccc(C(N)C2CCCS2)o1>>Cc1ccc(C(Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N4CCN(C)CC4)c3O)c(=O)c2=O)C2CCCS2)o1,,CO,,,,val
US04931560,Cc1cc(C2CC2)nc(Cl)n1.Nc1cccc(F)c1>>Cc1cc(C2CC2)nc(Nc2cccc(F)c2)n1,,CCO,,Cl,N,val
US05387684,CCCCc1nc(Cl)c(C=O)n1Cc1ccc2nn(-c3ccccc3C(=O)OCC)c(Br)c2c1>>CCCCc1nc(Cl)c(C=O)n1Cc1ccc2nn(-c3ccccc3C(=O)O)c(Br)c2c1,,O,,CCO,[K+].[OH-],val
US20160031934A1,COc1ccc(C[C@H](NC(=O)[C@@H](C)NC(=O)[C@@H]2CCc3[nH]ncc3C2)C(=O)OCc2ccccc2)cc1>>COc1ccc(C[C@H](NC(=O)[C@@H](C)NC(=O)[C@H]2CCc3[nH]ncc3C2)C(=O)O)cc1,[Pd],CO,,,,val
US20080039457A1,COc1ccc(C2(c3nnc(N)o3)CC2)cc1.NN>>COc1ccc(C2(c3nnc(N)n3N)CC2)cc1,,O,,,,val
US20030013720A1,CN1CCC(CNCCNc2ccc(F)c(F)c2)(c2ccc(I)cc2)CC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN1CCC(CN2CCN(c3ccc(F)c(F)c3)C2=O)(c2ccc(I)cc2)CC1,,C1CCOC1,CCOC(C)=O,,,val
US20030213931A1,CCCCCCCCCCCCCCCCCCO.O=C(O)C(=O)c1ccccc1>>CCCCCCCCCCCCCCCCCCOC(=O)C=O,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20120022107A1,CCOC(=O)c1cc(Br)c(C)[nH]1.N#C[Cu]C#N>>CCOC(=O)c1cc(C#N)c(C)[nH]1,,CN(C)C=O,O,,,val
US20060128807A1,COC(=O)c1ccc(O)cc1OC.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1ccc(OS(=O)(=O)C(F)(F)F)cc1OC,,CCOC(C)=O,ClCCl,Cl,c1ccncc1,val
US20040002545A1,CCCC[Sn](CCCC)(CCCC)c1cnc(F)c(Cl)c1.Cc1cc(Br)sn1>>Cc1cc(-c2ccnc(F)c2Cl)sn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOCC,Cc1ccccc1,,,val
US20100120741A1,COc1ccc(CCl)cc1.NN>>COc1ccc(CNN)cc1.Cl,,CCO,,O,,val
US20120214837A1,CCCc1nc(O)cc2cc(OC)c(OC)cc12.COc1ccc2nc(NCCNC(C)=O)c(CCl)cc2c1>>CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12,,C1CCOC1,ClCCl,Cl,[Li+].[OH-],val
US20150291595A1,COc1ccc(S(=O)(=O)Nc2cccc(B3OC(C)(C)C(C)(C)O3)c2)cc1.Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3Br)n(-c3ccccc3)c(=O)c12>>COc1ccc(S(=O)(=O)Nc2cccc(-c3c(N)ncnc3N[C@@H](C)c3nn4ccc(C)c4c(=O)n3-c3ccccc3)c2)cc1,c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd-4]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US03998853,C=C(C#N)C(=C)C#N.CCCC(C#N)CC=CCCC#N>>CCCC(C#N)CCCC(C#N)=C(C#N)CCCCC#N,,ClCCl,,,,val
US05872136,O=C(O)c1ccc(-c2ccccc2C(F)(F)F)nc1>>OCc1ccc(-c2ccccc2C(F)(F)F)nc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100144694A1,CC(Cl)C(=O)N(NC(=O)OC(C)(C)C)C1C2CC3CC(C2)CC1C3>>CC1NN(C2C3CC4CC(C3)CC2C4)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100160302A1,O=C(NC12CC3CC1CC(c1ccc(N4CCCS4(=O)=O)cc1)(C3)C2)OCc1ccccc1>>NC12CC3CC1CC(c1ccc(N4CCCS4(=O)=O)cc1)(C3)C2,[Pd],CO,,,,val
US20120040984A1,COC(=O)[C@@H]1CC[C@@H](Oc2ccc(C(=O)O)cc2)CC1.Nc1nnc(Cc2ccccc2)s1>>COC(=O)[C@@H]1CC[C@@H](Oc2ccc(C(=O)Nc3nnc(Cc4ccccc4)s3)cc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20020143186A1,COC(=O)c1cc(N)ccc1OC(F)(F)F>>Nc1ccc(OC(F)(F)F)c(CO)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160113957A1,CCCCCCCCCCCCCCCCCCBr.CCCCCCCCCCCCCCCCCCC(CCCCCCCCCCCCCCCCCC)C(=O)O>>CCCCCCCCCCCCCCCCCCC(CCCCCCCCCCCCCCCCCC)(CCCCCCCCCCCCCCCCCC)C(=O)O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20080176894A1,CN(C)c1ccc(B(O)O)cc1.Nc1ncc(Br)cc1[N+](=O)[O-]>>CN(C)c1ccc(-c2cnc(N)c([N+](=O)[O-])c2)cc1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20030114683A1,CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)O.CCI>>CCO[C@@H]1C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C1,,C1CCOC1,,[H-].[Na+],,val
US20040220185A1,CC(C)(C)OC(=O)N1CCN(c2ccc(C#C[Si](C)(C)C)cn2)CC1>>C#Cc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US04204870,O=C(Cl)c1ccccc1.O=S(=O)(O)c1cc(N=Nc2ccccn2)c(O)c2ccccc12>>O=C(Oc1c(N=Nc2ccccn2)cc(S(=O)(=O)O)c2ccccc12)c1ccccc1,,CC(C)=O,,CCN(CC)CC,c1ccncc1,val
US20160176871A1,COCCO.COc1ccc(-c2c(-c3ccnc(NC(C)=O)c3)n(COCC[Si](C)(C)C)c3cc(O)cnc23)nc1>>COCCOc1cnc2c(-c3ccc(OC)cn3)c(-c3ccnc(NC(C)=O)c3)n(COCC[Si](C)(C)C)c2c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090264445A1,COC(=O)C(CC1CC2CCC1C2)N1CC(Oc2c(F)cccc2F)=CC1=O>>O=C(O)C(CC1CC2CCC1C2)N1CC(Oc2c(F)cccc2F)=CC1=O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20060014953A1,CC(C)(C)OC(=O)N1CCn2nc(C(F)(F)F)nc2C1=CC1CC1>>CC(C)(C)OC(=O)N1CCn2nc(C(F)(F)F)nc2C1CC1CC1,[Pd],CCO,,,,val
US04167567,Cc1ccc(N=C=O)cc1.O=C(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCNCC1>>Cc1ccc(NC(=O)N2CCN(C(=O)c3ccc(Nc4ccnc5cc(C(F)(F)F)ccc45)cc3)CC2)cc1,,ClCCl,,,,val
US20160222031A1,C=CCN1C(=O)C2SSSSC1C(=O)N2CC=C>>C=CCN1C(=O)C(S)N(CC=C)C(=O)C1S,,C1CCOC1,CO,[BH4-].[Na+],,val
US06403610B1,COC(=O)[C@H]1CN(CCc2ccc(Cl)s2)CC[C@H]1CCC(O)c1ccnc2ccc(OC)cc12>>COc1ccc2nccc(C(O)CC[C@@H]3CCN(CCc4ccc(Cl)s4)C[C@@H]3C(=O)O)c2c1,,C1COCCO1,,[Na+].[OH-],,val
US20040180911A1,CCc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1[C@H]1C[C@@H](C(=O)OC)C1>>CCc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1[C@@H]1C[C@H](CO)C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05563163,CCN(CC)C(=O)Cl.COc1ccc(Br)c(C(C)C)c1>>CCN(CC)C(=O)c1ccc(OC)cc1C(C)C,,CCOCC,,[Li]CCCC,,val
US20090023704A1,BrCCCBr.CCc1nc2[nH]c(=O)n(Cc3ccc(Cl)cc3)c(=O)c2n1C>>CCc1nc2c(c(=O)n(Cc3ccc(Cl)cc3)c(=O)n2CCCBr)n1C,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20140235647A1,CS(=O)(=O)Cl.Nc1cccc2sccc12>>CS(=O)(=O)Nc1cccc2sccc12,,ClCCl,,c1ccncc1,,val
US20030216432A1,CCCI.Cc1cc2c(cc1Br)NC(=O)CC2(C)C>>CCCN1C(=O)CC(C)(C)c2cc(C)c(Br)cc21,,CS(C)=O,,O,[K+].[OH-],val
US20050282812A1,CCC1CN(C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2cc(C(F)(F)F)ccc2N1CCCCC(=O)OC>>CCC1CN(C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2cc(C(F)(F)F)ccc2N1CCCCCO,,C1CCOC1,,[BH4-].[Li+],,val
US20070244159A1,CC(C)(C)c1c[nH]c2ccc([N+](=O)[O-])cc12>>CC(C)(C)c1c[nH]c2ccc(N)cc12,[Ni],CO,,,,val
US20140243370A1,CCNC1=N[C@H]2[C@H](O[C@H](C(=O)N(C)OC)[C@@H](O)[C@@H]2O)S1>>CCNC1=N[C@H]2[C@H](O[C@H](C=O)[C@@H](O)[C@@H]2O)S1,,C1CCOC1,Cc1ccccc1,CC(C)C[AlH]CC(C)C,,val
US04804773,CCCC[Si](CCCC)(CCCC)OC1(C(F)(F)F)C=CC(=O)C=C1>>Oc1ccc(C(F)(F)F)cc1,[Zn],CCO,,CC(=O)O,O,val
US04018922,CC1(OCCO)CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1.CCCCCC(C)C(=O)Cl>>CCCCCCC(=O)OC(C)COC1(C)CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1,,c1ccccc1,,CCN(CC)CC,,val
US20100256127A1,CC(C)N.COC(=O)c1ccc(OCc2c(-c3ccc(F)c(F)c3)noc2CO)nc1>>CC(C)NC(=O)c1ccc(OCc2c(-c3ccc(F)c(F)c3)noc2CO)nc1,,C1COCCO1,,C[Al](C)C,,val
US20100267666A1,CC(C)(C)C(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3cc(C(=O)NCCO)cc(N4CCCC4)c3)nc12>>CC(C)(C)C(=O)c1c[nH]c2ncc(-c3cc(C(=O)NCCO)cc(N4CCCC4)c3)nc12,,CO,ClCCl,,,val
US20020119961A1,CC(C)(C)OC(=O)N1C2CCC1C(=O)N(Cc1ccc(F)cc1)C2>>O=C1C2CCC(CN1Cc1ccc(F)cc1)N2,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US05250698,C=O.CC(C)(C)CC(C)(C)c1ccc(O)c(-n2nc3ccccc3n2)c1.CCNCC>>CCN(CC)Cc1cc(C(C)(C)CC(C)(C)C)cc(-n2nc3ccccc3n2)c1O,,CCCCO,,Cc1ccccc1,,val
US06225310B1,CC(C)N=C=S.CCOC(=O)Nc1sc(C)c(C#N)c1S(N)(=O)=O>>CCOC(=O)Nc1sc(C)c(C#N)c1S(=O)(=O)NC(=S)NC(C)C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110196153A1,COC(=O)c1cc(F)cc2c1C(=O)C(c1ncnn1C)C(c1ccc(F)cc1)N2O>>COC(=O)c1cc(F)cc2c1C(=O)C(c1ncnn1C)C(c1ccc(F)cc1)N2,[Fe],CO,,Cl,,val
US20050148627A1,CCOC(=O)C1=Cc2cc(C=O)cc(C)c2OC1C(F)(F)F>>CCOC(=O)C1=Cc2cc(CO)cc(C)c2OC1C(F)(F)F,,C1CCOC1,CCO,Cl,[BH4-].[Na+],val
US20060166997A1,CO.Cl.N#CC(O)c1cccc(OC(F)(F)C(F)F)c1>>COC(=N)C(O)c1cccc(OC(F)(F)C(F)F)c1.Cl,,CCOCC,,C1COCCO1,,val
US20040087577A1,Nn1c(=O)c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc21.O=Cc1ccsc1>>O=c1c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc2n1N=Cc1ccsc1,,CC(=O)N(C)C,,,,val
US20110152273A1,COC(=O)c1c(C#N)cc(Cl)nc1Nc1cccc(C)c1.COC[C@@H](CN)NC(=O)OC(C)(C)C>>COC[C@@H](CNc1cc(C#N)c(C(=O)OC)c(Nc2cccc(C)c2)n1)NC(=O)OC(C)(C)C,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20060094750A1,CCSSCC.C[Si]1(C)CC[Si](C)(C)N1c1ccc(Br)cn1>>CCSc1ccc(N)nc1,,C1CCOC1,,[Li]CCCC,,val
US20060281784A1,CC(C)CN(CC(C)C)C(=O)C(C)(C)c1ccc([N+](=O)[O-])c(Cl)c1.NCCCN1CCCCC1>>CC(C)CN(CC(C)C)C(=O)C(C)(C)c1ccc([N+](=O)[O-])c(NCCCN2CCCCC2)c1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US06323227B1,COCCOCOc1ccc(C#N)cc1/C=C/CN1C(=O)c2ccccc2C1=O>>COCCOCOc1ccc(C#N)cc1/C=C/CN,,CCO,,NN,O,val
US06608070B1,CC(=O)N(C)C.Fc1cc(Br)ccc1Cl>>CC(=O)c1ccc(Cl)c(F)c1,,CCOCC,,[Li]CCCC,[Cl-].[NH4+],val
US04396627,CC(=O)Cc1ccc(C(C)=O)cc1.NCC(O)c1ccccc1>>CC(=O)c1ccc(CC(C)NCC(O)c2ccccc2)cc1,O=[Pt],c1ccccc1,,CCO,,val
US20120196864A1,CCN1C(=N)/C(=C/c2ccc(O)c(OC)c2)NC1=O.N#Cc1ccc(F)c(C(F)(F)F)c1>>CCN1C(=N)/C(=C/c2ccc(Oc3ccc(C#N)cc3C(F)(F)F)c(OC)c2)NC1=O,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20080221082A1,C=Cc1[nH]c(NC2CCC(CNCCN3C(=O)CCC(C(C(=O)O)C(C)(C)C)=C4CC=CC=C43)CC2)nc1/C=C\C.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C(O)CC1CCC(=O)N(CCNCC2CCC(Nc3nc4ccccc4[nH]3)CC2)c2ccccc21,,ClCCl,,,,val
US20070219210A1,CCOC(=O)C(=O)CC(=O)c1cc(C)ccn1.NNc1ccc(Cl)nn1>>CCOC(=O)c1cc(-c2cc(C)ccn2)n(-c2ccc(Cl)nn2)n1,,CCO,CCOC(C)=O,Cl,O=C([O-])O.[Na+],val
US05780634,Cc1ccc2nc(-c3ccccc3C(=O)O)cc(C(=O)O)c2c1>>Cc1ccc2nc(-c3ccccc3C(=O)O)ccc2c1,,CC(=O)N(C)C,,O,O=C([O-])[O-].[Na+].[Na+],val
US20120101127A1,Cc1cc(F)cc2c1NC(c1cccc(Br)c1)CC2(C)C.NC1(C(=O)O)CC1>>Cc1cc(F)cc2c1NC(c1cccc(NC3(C(=O)O)CC3)c1)CC2(C)C,[Cu]I,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080262042A1,CCOC(C)=O.CCOC(C)=O.COc1ccc(S(=O)(=O)n2cc(CN(C)C(=O)OC(C)(C)C)c(F)c2-c2cccnc2F)cn1>>CNCc1cn(S(=O)(=O)c2ccc(OC)nc2)c(-c2cccnc2F)c1F.O=C(O)/C=C/C(=O)O,,CCO,,Cl,,val
US20030199440A1,CCOC(=O)C1(NS(=O)(=O)c2ccc3c(Cl)cnc(NC(=N)N)c3c2)CCC1.Cl>>Cl.N=C(N)Nc1ncc(Cl)c2ccc(S(=O)(=O)NC3(C(=O)O)CCC3)cc12,,CO,,[Na+].[OH-],,val
US20060014827A1,Brc1cncc(C2=CCCC2)c1.O=CN1CCOCC1>>O=Cc1cncc(C2=CCCC2)c1,,CCOCC,,O,[Li]CCCC,val
US07183290B2,CC(C)(C)OC(=O)NC1CCN(c2ccc(C(F)(F)F)cc2)CC1.Cl>>Cl.NC1CCN(c2ccc(C(F)(F)F)cc2)CC1,,C1COCCO1,,,,val
US07629358B2,COC(=O)c1cccc(CC(C)(C)NC[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(OCc3ccccc3)c(CO)c2)c1>>COC(=O)c1cccc(CC(C)(C)NC[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(O)c(CO)c2)c1,[Pd],CO,,,,val
US20070254933A1,CNC(=O)c1ccc(NC2(C#N)CCCC2)cc1F.N#Cc1ccc(N=C=S)cc1C(F)(F)F.O>>CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C23CCCC3)cc1F,,CN(C)C=O,O,CO,Cl,val
US20100056566A1,CN1C2CCC1CC(O)C2.Oc1ccc2cnccc2c1>>CN1C2CCC1CC(Oc1ccc3cnccc3c1)C2,,CCN(CC)CC,ClCCl,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110039829A1,CCOC(=O)C1(Br)CCC1.CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(O)n(-c3ccccc3)n2)CC1>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OC3(C(=O)OCC)CCC3)n(-c3ccccc3)n2)CC1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130324531A1,COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F.OCC(CO)CO>>COc1cc(C(=O)OCC(CO)CO)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F,,C1CCOC1,,[H-].[Na+],,val
US20050085508A1,Cc1ccc(N(C(=O)c2ccco2)C2CCN(CCC3(CCO[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)CCN(Cc4ccccc4)CC3)CC2)cc1>>Cc1ccc(N(C(=O)c2ccco2)C2CCN(CCC3(CCO)CCN(Cc4ccccc4)CC3)CC2)cc1,,C1CCOC1,,,,val
US20080221114A1,C1CCNCC1.Cn1nc(N2c3ccccc3C[C@H]2C(=O)O)ccc1=O>>Cn1nc(N2c3ccccc3C[C@H]2C(=O)N2CCCCC2)ccc1=O,,C1CCOC1,,O,O=C(n1ccnc1)n1ccnc1,val
US20020072603A1,O=c1cnn(-c2ccc(C(Cl)c3ccc(Cl)cc3)c(Cl)c2)c(=O)[nH]1.OC1CCNCC1>>O=c1cnn(-c2ccc(C(c3ccc(Cl)cc3)N3CCC(O)CC3)c(Cl)c2)c(=O)[nH]1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20110251196A1,CC(C)CO.C[C@H](C(=O)N[C@H](c1ccc(O)cc1)[C@H]1CCCN1C(=O)OC(C)(C)C)c1ccccc1>>CC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@H]2CCCN2C(=O)OC(C)(C)C)cc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080004309A1,C1CCNCC1.CCOC(=O)c1nc(I)c2nc(-c3ccccc3)sc2c1OCc1ccccc1>>CCOC(=O)c1nc(N2CCCCC2)c2nc(-c3ccccc3)sc2c1OCc1ccccc1,,CCO,,CCN(CC)CC,,val
US20090131461A1,COc1cc2c(Oc3ccc(NC(=O)c4ccccc4)cc3)ccnc2cc1OCC[C@H](NC(=O)C(C)(C)C)C(=O)O>>COc1cc2c(Oc3ccc(NC(=O)c4ccccc4)cc3)ccnc2cc1OCC[C@H](N)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060069110A1,CCOC(=O)c1cnc(-c2ccccc2)nc1Nc1ccnc(F)n1.NCCc1ccccn1>>CCOC(=O)c1cnc(-c2ccccc2)nc1Nc1ccnc(NCCc2ccccn2)n1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130237525A1,COC(=O)CCCC(NS(=O)C(C)(C)C)c1c(OC)cncc1OC>>COC(=O)CCCC(N)c1c(OC)cncc1OC,,CO,,C1COCCO1,Cl,val
US05521103,Br.CC(C)(C)OC(=O)CCI.O=C(Oc1ccccc1)c1c2ccccc2nc2ccccc12>>O=C(O)CC[n+]1c2ccccc2c(C(=O)Oc2ccccc2)c2ccccc21.[Br-],,CC(=O)O,O,c1ccccc1,,val
US20140375943A1,O=C(OCCCOCc1ccccc1)c1cc(C(=O)OCCCOCc2ccccc2)cc(-c2ccc(OCc3ccccc3)cc2)c1>>O=C(OCCCO)c1cc(C(=O)OCCCO)cc(-c2ccc(O)cc2)c1,[Pd],C1CCOC1,,C,,val
US20150284335A1,COC(=O)c1nc2cc(N)ccc2[nH]1.O=Cc1ccccc1>>COC(=O)c1nc2ccc(NCc3ccccc3)cc2[nH]1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100130506A1,NCCC[C@H]1CN/C(=N\C(=O)c2nc(Cl)c(N)nc2N)N1.NCc1ccccc1.O=C(n1ccnc1)n1ccnc1>>Nc1nc(N)c(C(=O)/N=C2\NC[C@H](CCCNC(=O)NCc3ccccc3)N2)nc1Cl,,CN(C)C=O,CO,CCOCC,,val
US20040127538A1,CC(=O)O.N#Cc1ccc2[nH]nc(-c3cc4ccccc4s3)c2c1.O=S(=O)(O)O>>O=C(O)c1ccc2[nH]nc(-c3cc4ccccc4s3)c2c1,,CCOC(C)=O,,O,,val
US20100120741A1,CCOC(=O)c1nc2c(=O)[nH]c3ccc(Cl)cc3n2n1>>O=C(O)c1nc2c(=O)[nH]c3ccc(Cl)cc3n2n1,,CCO,,O,[Na+].[OH-],val
US05843957,BrC(Br)(Br)Br.CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(C#CCO)c2)c2cccnc21>>CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(C#CCBr)c2)c2cccnc21,,ClCCl,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130116430A1,COCCN.O=[N+]([O-])c1cnc(Cl)c(Br)c1>>COCCNc1ncc([N+](=O)[O-])cc1Br,,O,,C1CCOC1,CCN(CC)CC,val
US20110306607A1,COc1ccc(C(=O)Cl)cc1C(F)(F)F.OC1(O)CCNCC1>>COc1ccc(C(=O)N2CCC(=O)CC2)cc1C(F)(F)F,,Cc1ccccc1,,Cl,[Na+].[OH-],val
US20050009805A1,C1CN2CCC1CC2.S=C=NCCCBr>>S=C=NCCC[N+]12CCC(CC1)CC2.[Br-],,CC#N,,,,val
US06177440B1,COC(=O)c1cccc2c1c1c(n2Cc2cccc(F)c2)CCCC1=O>>COC(=O)c1cccc2c1c1c(O)cccc1n2Cc1cccc(F)c1,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20070060577A1,CCOC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(OCC(O)CN(C)C)cc3)ncc2c1=O.CN>>CNC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(OCC(O)CN(C)C)cc3)ncc2c1=O,,CO,,,,val
US20150329538A1,Brc1cccc2cccnc12.C=C(OCC)[Sn](CCCC)(CCCC)CCCC>>CC(=O)c1cccc2cccnc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20120329780A1,CN1CCN(c2ccc(N)cc2)CC1.COc1ccc(Cn2cc3nc(-c4cccc(S(N)(=O)=O)c4)nc(Cl)c3n2)cc1>>CN1CCN(c2ccc(Nc3nc(-c4cccc(S(N)(=O)=O)c4)nc4cn[nH]c34)cc2)CC1,C1COCCO1,CO,,Cl,,val
US20120214762A1,COc1ncccc1N.Clc1ncnc(Cl)n1>>COc1ncccc1Nc1ncnc(Cl)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,ClCCl,val
US20140221341A1,CN(C)NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OCc1ccccc1>>CN(C)NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2O,[Pd],CO,,,,val
US20050020684A1,CCOC(=O)COc1ccc(-c2ccccc2)cc1>>OCCOc1ccc(-c2ccccc2)cc1,,Cc1ccccc1,,CC(C)C[AlH]CC(C)C,,val
US20100063047A1,N#CC1CCc2cc(Cl)ccc21>>NCC1CCc2cc(Cl)ccc21,,C1CCOC1,,B,,val
US03932443,CNC(=NCCSCc1[nH]cnc1C)NC#N.O>>CNC(=NCCS(=O)Cc1[nH]cnc1C)NC#N,,O,,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20080234306A1,O=C(OO)c1cccc(Cl)c1.O=C1CC[C@@]2(OCC3CC3)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5>>O=C1CC[C@@]2(OCC3CC3)[C@H]3Cc4ccc(O)c5c4[C@@]2(CC[N+]3([O-])CC2CC2)[C@H]1O5,,ClC(Cl)Cl,,O=C([O-])[O-].[K+].[K+],,val
US20100029650A1,CSc1ccc(B(O)O)cc1.Oc1ccc(Br)nc1>>CSc1ccc(-c2ccc(O)cn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20160060197A1,CC(O)(c1ccccc1O)C1CC1.O=C1CCC(=O)N1Br>>CC(O)(c1cccc(Br)c1O)C1CC1,,ClCCl,,CC(C)NC(C)C,,val
US20090131473A1,CCOc1cc(C(Oc2ccc(CC(=O)OC(C)(C)C)cc2)C(=O)OCc2ccccc2)ccc1OC(C)C>>CCOc1cc(C(Oc2ccc(CC(=O)OC(C)(C)C)cc2)C(=O)O)ccc1OC(C)C,[Pd],,,,,val
US20120149632A1,CC(C)(C)OC(=O)NCCCN(CCCCN(CCCN(CC(=O)OCc1ccccc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NCCCN(CCCCN(CCCN(CC(=O)O)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,[Pd],CO,,,,val
US20130190268A1,COC(=O)CCCCCOCCCCC[C@@H]1SC[C@H]2[C@@H]1N(Cc1ccc(OC)cc1)C(=O)N2Cc1ccc(OC)cc1>>COC(=O)CCCCCOCCCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21,,O=C(O)C(F)(F)F,,Cc1ccccc1,,val
US20100168094A1,CCOC(=O)C=Cc1ccc(OCc2ccccc2)c(C2CCCC2)c1>>CCOC(=O)CCc1ccc(O)c(C2CCCC2)c1,[Pd],CCO,,,,val
US20140275528A1,Cn1c(N)c(N)c(=O)n(C)c1=O.O=C1CCCC(=O)O1>>Cn1c(N)c(NC(=O)CCCC(=O)O)c(=O)n(C)c1=O,,CCO,CN(C)C=O,Cl,[Na+].[OH-],val
US05002966,CCN(CC)C(=O)c1ccc(CCCOCCCCCCNCC(O)c2cc(Cl)c(N)c(Cl)c2)o1>>CCN(CC)Cc1ccc(CCCOCCCCCCNCC(O)c2cc(Cl)c(N)c(Cl)c2)o1,,CCOCC,c1ccccc1,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04675332,COC(=O)c1c(O)c2ccccc2n1-c1ccccc1.ClCc1ccccc1>>COC(=O)c1c(OCc2ccccc2)c2ccccc2n1-c1ccccc1,,CN(C)P(=O)(N(C)C)N(C)C,,[H-].[Na+],,val
US20090163472A1,CC(C)(C)OC(=O)N1C[C@@H](N=[N+]=[N-])C[C@H]1CO>>CC(C)(C)OC(=O)N1C[C@@H](N)C[C@H]1CO,[Pd],CO,,,,val
US20160257676A1,C=O.COc1cc(-c2c(C3CC3)nn(Cc3ccccc3)c2N)ccc1Br>>COc1cc2c(cnc3c2c(C2CC2)nn3Cc2ccccc2)cc1Br,,O=C(O)C(F)(F)F,,,,val
US20050267149A1,COC(=O)c1ccccc1CBr.O=C(O)Cc1cccc(O)c1>>COC(=O)c1ccccc1COc1cccc(CC(=O)O)c1,,CCO,,[K+].[OH-],,val
US05837711,CI.COc1ccc(NS(C)(=O)=O)cc1C1OCCO1>>COc1ccc(N(C)S(C)(=O)=O)cc1C1OCCO1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US04407806,Clc1ccc(C(Cl)c2cccnc2)c(Cl)c1.Oc1ccccc1>>Clc1ccc(C(Oc2ccccc2)c2cccnc2)c(Cl)c1,,Cc1ccccc1,,O,[Na],val
US20090181943A1,C[S+](C)C.O=C(c1ccccc1)c1ccc(Br)cc1>>Brc1ccc(C2(c3ccccc3)CO2)cc1,,C1CCOC1,,[H-].[Na+],,val
US20120077799A1,O=S1(=O)CCN2C=CC=C(c3ccc(C(F)(F)F)cc3)C2=N1>>O=S1(=O)CCN2CCCC(c3ccc(C(F)(F)F)cc3)C2=N1,O=[Pt]=O,CO,,,,val
US20150045340A1,CS(=O)(=O)Cl.O=C1c2ccccc2C(=O)N1OCCO>>CS(=O)(=O)OCCON1C(=O)c2ccccc2C1=O,,ClCCl,,CCN(CC)CC,,val
US06040345,CC(Oc1c(Cl)cc([N+](=O)[O-])cc1Cl)C(F)(F)C(F)(F)C(F)(F)F>>CC(Oc1c(Cl)cc(N)cc1Cl)C(F)(F)C(F)(F)C(F)(F)F,[Fe],CCO,,Cl,O,val
US20140206663A1,CC1(N)CN(C(=O)OC(C)(C)C)C1.CC1C(=O)N(COCC[Si](C)(C)C)N=C2COc3cc(C(F)(F)F)c(Br)cc3N21>>CC1C(=O)N(COCC[Si](C)(C)C)N=C2COc3cc(C(F)(F)F)c(NC4CN(C(=O)OC(C)(C)C)C4)cc3N21,CC(=O)O[Pd]OC(C)=O,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1,O=C([O-])[O-].[Cs+].[Cs+],val
US20080300270A1,C/C(N)=C\C#N.CCCC1CC(=O)CC(=O)C1.CCOc1cc(C=O)cc([N+](=O)[O-])c1OCc1cccc(OC)c1>>CCCC1CC(=O)C2=C(C1)NC(C)=C(C#N)C2c1cc(OCC)c(OCc2cccc(OC)c2)c([N+](=O)[O-])c1,,CCO,,,,val
US20140206606A1,COC(=O)c1ccc(C(OC)OC)cc1[N+](=O)[O-]>>COC(=O)c1ccc(C=O)cc1[N+](=O)[O-],,CC(C)=O,,Cl,,val
US20140235671A1,CCOC(=O)CCCCCCN(c1ccccn1)c1cc(-c2ccccc2F)ccn1.NO>>O=C(CCCCCCN(c1ccccn1)c1cc(-c2ccccc2F)ccn1)NO,,CN(C)C=O,CO,,,val
US20130303550A1,C1CCOC1.COc1cc(C2C(C(=N)NO)=C(N)Oc3c2ccc2ccccc32)cc(Br)c1OC.O>>COc1cc(C2C(c3noc(=O)[nH]3)=C(N)Oc3c2ccc2ccccc32)cc(Br)c1OC,,O,,,,val
US20090291978A1,CC(C)COC(C)ONC(=O)c1cc2ccc(CO)cc2s1>>CC(C)COC(C)ONC(=O)c1cc2ccc(C=O)cc2s1,O=[Mn]=O,ClCCl,,,,val
US20120329780A1,CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.COc1ccc(Cn2cc3nc(-c4ccsc4)nc(Cl)c3n2)cc1>>N[C@@H]1CCCC[C@@H]1Nc1nc(-c2ccsc2)nc2cn[nH]c12,C1COCCO1,CO,,Cl,,val
US05137895,C1CCOC1.CN(C)C=O.CO.O=C(O)/C=C/C(=O)O.O=C(O)c1c[nH]c2ccccc12.O=C(n1ccnc1)n1ccnc1>>O.O=C(NCC1(O)CN2CCC1CC2)c1c[nH]c2ccccc12.O=C(O)/C=C/C(=O)O,,CO,,,,val
US20070149546A1,C[C@H](CN(C)C)Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12.Fc1cccc(CCl)c1>>C[C@H](CN(C)C)Oc1cccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12,,CN(C)C=O,O,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US04452625,CC(C)(C)C(=O)C(=CC1CCCCC1)n1cncn1>>CC(C)(C)C(O)C(=CC1CCCCC1)n1cncn1,,CO,,[BH4-].[Na+],,val
US20150005279A1,CCO/C=C/c1cc2c(-c3cccc(N)c3)ccc(C(N)=O)c2n1COCC[Si](C)(C)C>>CCOCCc1cc2c(-c3cccc(N)c3)ccc(C(N)=O)c2n1COCC[Si](C)(C)C,[Pd],CO,,,,val
US04245097,CO.O=C(O)c1ccc(NCCCCCCCCCCCCCCCCBr)cc1>>COC(=O)c1ccc(NCCCCCCCCCCCCCCCCBr)cc1,,CO,,CCOCC,FB(F)F,val
US20120129811A1,COc1ccccc1N=C=S.Cn1cnc2c(N)cccc21>>COc1ccccc1NC(=S)Nc1cccc2c1ncn2C,,CN(C)C=O,,,,val
US20070244155A1,CCOC(=O)C1=Cc2ccc(OCc3ccccc3)cc2OCC1>>OCC1=Cc2ccc(OCc3ccccc3)cc2OCC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US08426414B2,BrCC1CCC1.CC[C@H](C)[C@@H](CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(O)cc1)NC(=O)OC(C)(C)C>>CC[C@H](C)[C@@H](CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1)NC(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150119404A1,C#CC[C@@]1(NC(=O)OC(C)(C)C)CCN(C)C1=O.Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(I)n1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(C#CC[C@@]2(NC(=O)OC(C)(C)C)CCN(C)C2=O)n1,I[Cu]I,C1CCOC1,,CCNCC,,val
US06248755B1,COc1ccc(COC(=O)[C@@H](C2CCCCC2)N2C[C@H](c3ccccc3)[C@@H](C=O)C2)cc1.c1ccc2sc(C3CCNCC3)nc2c1>>COc1ccc(COC(=O)[C@@H](C2CCCCC2)N2C[C@H](c3ccccc3)[C@@H](CN3CCC(c4nc5ccccc5s4)CC3)C2)cc1,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05891909,Cc1cc(OCCCO)cc(OS(=O)(=O)c2ccccc2S(C)(=O)=O)c1>>Cc1cc(OCCC=O)cc(OS(=O)(=O)c2ccccc2S(C)(=O)=O)c1,,ClCCl,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20050009831A1,CC(C)OC(=O)N1CCC(NC(=O)N2CCn3c(c(C(N)=O)c(Cl)c3-c3ccccc3)C2)CC1.O=C(O)C(F)(F)F>>NC(=O)c1c(Cl)c(-c2ccccc2)n2c1CNCC2.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20050239751A1,C#Cc1cccc(N)c1.C=CS(=O)(=O)c1ccccc1>>C#Cc1cccc(NCCS(=O)(=O)c2ccccc2)c1,,CCO,,,,val
US20100298319A1,C1COCCN1.CCC(C)n1cnc2c(-c3cnc(N)nc3)nc(Cl)nc21>>CCC(C)n1cnc2c(-c3cnc(N)nc3)nc(N3CCOCC3)nc21,,CC(=O)N(C)C,,,,val
US04271163,CCC(=O)Nc1ccc(C(=O)[C@H]2C[C@H]2C(=O)O)cc1.NN>>CCC(=O)Nc1ccc(C2=NNC(=O)C3CC23)cc1,,CCO,,O,,val
US20160200704A1,Cc1nc(N)ccc1C#N>>Cc1nc(N)ccc1CN,[Ni],CO,,,,val
US20090162319A1,Cc1cc(Br)cc(C)c1Oc1nc(N(C(=O)OC(C)(C)C)c2ccc(C#N)cc2)nc(/C=C/N(C)C)c1[N+](=O)[O-]>>Cc1cc(Br)cc(C)c1Oc1nc(N(C(=O)OC(C)(C)C)c2ccc(C#N)cc2)nc2cc[nH]c12,,C1CCOC1,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20050256078A1,CCOC(=O)C(C)N(Oc1ccccc1)[PH](=O)CC(C)=CCc1c(CC)c(C)c2c(c1OCC[Si](C)(C)C)C(=O)OC2>>CCOC(=O)C(C)N(Oc1ccccc1)[PH](=O)CC(C)=CCc1c(O)c2c(c(C)c1CC)COC2=O,,ClCCl,O=C(O)C(F)(F)F,c1ccncc1,,val
US06228859B1,COc1ccc(Cn2cnc(N)c3nc(C(C)(C)OCc4ccccc4)nc2-3)cc1OC1CCCC1.Cl>>COc1ccc(Cn2cnc(N)c3nc(C(C)(C)O)nc2-3)cc1OC1CCCC1.Cl,[Pd],C1CCOC1,,CO,,val
US06300363B1,CCOC(=O)Nc1cc(C)ccc1C#N.O=C(CBr)c1ccccc1>>CCOC(=O)n1c(C(=O)c2ccccc2)c(N)c2ccc(C)cc21,,CCOC(C)=O,,,,val
US20140066424A1,CCOC(=O)c1ncc(-c2ccc(OC(F)(F)F)cc2)o1.NN>>NNC(=O)c1ncc(-c2ccc(OC(F)(F)F)cc2)o1,,CCO,,O,,val
US05714487,Fc1ccc(CBr)cc1.O[C@@H]1C[C@H]2CN(c3ncc(F)cn3)CCN2C1>>Fc1ccc(CO[C@@H]2C[C@H]3CN(c4ncc(F)cn4)CCN3C2)cc1,,CN(C)C=O,O,[H-].[Na+],,val
US20150057260A1,CCOC(=O)c1ncccc1F.NC1COC1>>CCOC(=O)c1ncccc1NC1COC1,,CS(C)=O,,CCN(CC)CC,,val
US20050272721A1,CCS(=O)(=O)O.Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1>>CCS(=O)(=O)[O-].Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1,,CC(C)=O,,,,val
US20070072859A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(CC[C@@H](O)CN1CCCC1)Cc1ccccc1>>CN(CC[C@@H](O)CN1CCCC1)C(=O)OC(C)(C)C,[Pd],CCO,,[H][H],,val
US20090137581A1,Clc1ncnc2nc[nH]c12.NCc1cc2cccc(Cl)c2nc1Oc1ccccc1>>Clc1cccc2cc(CNc3ncnc4[nH]cnc34)c(Oc3ccccc3)nc12,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20030055071A1,COC(=O)c1nc(C(=O)NCc2ccc(F)cc2SC)c(O)c2ncccc12>>CSc1cc(F)ccc1CNC(=O)c1nc(C(=O)O)c2cccnc2c1O,,C1COCCO1,CO,[Na+].[OH-],,val
US20020061883A1,CNOCC(=O)O.Cc1ccc(C)c(N=C=S)c1>>Cc1ccc(C)c(NC(=S)N(C)OCC(=O)O)c1,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US20130252938A1,Brc1cnc(C2=CCOCC2)nc1.O=C(OO)c1cccc(Cl)c1>>Brc1cnc(C23CCOCC2O3)nc1,,ClCCl,,,,val
US20050096389A1,CCO.Cc1ccccc1.O=c1oc(=O)c2ccccc2c2ccccc12>>CCOC(=O)c1ccccc1-c1ccccc1C(=O)OCC,,O,,O=S(=O)(O)O,,val
US20040167171A1,COC(=O)C(C)(C)Oc1cc(C)c(C)c(Br)c1C>>Cc1cc(OC(C)(C)C(=O)O)c(C)c(Br)c1C,,CCCCCC,,,,val
US20150353565A1,CC1(C)OB(c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)OC1(C)C.COc1ccc(CNc2ncnc3c2c(Br)nn3[C@@H]2CCCc3c2cnn3S(=O)(=O)c2ccc(C)cc2)c(OC)c1>>COc1ccc(CNc2ncnc3c2c(-c2ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc2)nn3[C@@H]2CCCc3c2cnn3S(=O)(=O)c2ccc(C)cc2)c(OC)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20100029605A1,CC(=N)CC#N.CSc1cc(NN)ncn1>>CSc1cc(-n2nc(C)cc2N)ncn1,,CCOC(C)=O,,CCO,,val
US20090018130A1,BrCc1ccc(Br)cc1.C1CCNCC1>>Brc1ccc(CN2CCCCC2)cc1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20150232460A1,CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)N[C@H]1CCC[C@]1(C)Nc1cnc(C(F)(F)F)cn1>>C[C@]1(Nc2cnc(C(F)(F)F)cn2)CCC[C@@H]1N,,CC(=O)O,,Br,,val
US20110053916A1,CC(=O)OCCc1cnc(-c2ccc(S(=O)(=O)NC(C)(C)C)s2)nc1Nc1cc(C2CC2)[nH]n1>>CC(=O)OCCc1cnc(-c2ccc(S(N)(=O)=O)s2)nc1Nc1cc(C2CC2)[nH]n1,,O=C(O)C(F)(F)F,,,,val
US20120122853A1,CCOC(=O)C(C)(C)Br.Nc1ccc(Br)cc1O>>CC1(C)Oc2cc(Br)ccc2NC1=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130045986A1,CC(C)(C)OC(=O)N1CCC(c2nc3cc(-c4ccc(-n5cnnn5)cc4F)ccc3o2)CC1.O=C(O)C(F)(F)F>>Fc1cc(-n2cnnn2)ccc1-c1ccc2oc(C3CCNCC3)nc2c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20050113580A1,COC(=O)Cc1cccc(OCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(c2ccccc2)c2ccccc2)c1>>O=CCc1cccc(OCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(c2ccccc2)c2ccccc2)c1,,Cc1ccccc1,,CC(C)C[AlH]CC(C)C,,val
US06194441B1,CC(=O)OC(C)=O.CC(C)(C)[Si](C)(C)OCc1cn(-c2ccc(N3C[C@H](CN=[N+]=[N-])OC3=O)cc2F)cn1>>CC(=O)NC[C@H]1CN(c2ccc(-n3cnc(CO[Si](C)(C)C(C)(C)C)c3)c(F)c2)C(=O)O1,[Pd],CCOC(C)=O,,CCN(CC)CC,,val
US05084461,O=C(O)CCCCCCC=CCCC(F)(F)F>>O=C(O)CCCCCCCCCCC(F)(F)F,[Pd],CCO,,,,val
US20120225878A1,COC(=O)c1cnc(NC(=O)c2cn(Cc3ccc(Cl)c(Cl)c3)nn2)s1>>O=C(Nc1ncc(C(=O)O)s1)c1cn(Cc2ccc(Cl)c(Cl)c2)nn1,,CCO,,[Na+].[OH-],,val
US20070197512A1,CCOC(=O)/C=C/C(=O)N1CC(C(C)C)Oc2cc(C)ccc21>>Cc1ccc2c(c1)OC(C(C)C)CN2C(=O)/C=C/C(=O)O,,CO,,[Na+].[OH-],,val
US20130274260A1,O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1cccc(CCl)c1.OB(O)c1cncc(F)c1>>O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1cccc(Cc2cncc(F)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,[I-].[Na+],,val
US20150232459A1,COC(=O)NCCCn1nc(C(C)=O)cc1-c1ccccn1.NC1CC1>>COC(=O)NCCCn1nc(C(C)NC2CC2)cc1-c1ccccn1,,CC(=O)O,ClCCl,O=C([O-])O.[Na+],,val
US20150299156A1,BrCc1ccccc1.CC(CO)CO>>CC(CO)COCc1ccccc1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US06090949,COC(=O)c1ccc(O)cc1.ClCCCl>>COC(=O)c1ccc(OCCCl)cc1,,O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20090163488A1,Cc1cccnc1C(=O)Nc1cccc(Oc2ccc3nc(N)cn3c2)c1.Clc1ccnc(Cl)n1>>Cc1cccnc1C(=O)Nc1cccc(Oc2ccc3nc(Nc4ccnc(Cl)n4)cn3c2)c1,,O=C([O-])O,[Na+],CC(=O)N(C)C,,val
US20080021032A1,CC(C)(C)[Si](C)(C)OCCn1ccc(N)n1.CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(CC(=O)O)n2)cc1Cl>>CC(C)(C)[Si](C)(C)OCCn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)cc2)n1,,ClCCl,,Cc1cccc(C)n1,O=C(Cl)C(=O)Cl,val
US20140005213A1,CC(C)(C)C(=O)OC(=O)C(C)(C)C.CC(C)(C)OC(=O)N[C@H]1CCN([C@H](c2ccc3nnc(-c4ccc5cc(F)c(OCCO)cc5n4)n3c2)C(F)(F)F)C1>>CC(C)C(=O)OCCOc1cc2nc(-c3nnc4ccc([C@@H](N5CC[C@H](NC(=O)OC(C)(C)C)C5)C(F)(F)F)cn34)ccc2cc1F,CN(C)c1ccncc1,c1ccncc1,,,,val
US20150368269A1,CCO.Cc1ccc(N2CCO[C@H]([C@@H](O)c3nc(=O)c4cc(C#N)ccc4[nH]3)C2=O)cc1>>CCOC(=N)c1ccc2[nH]c([C@H](O)[C@H]3OCCN(c4ccc(C)cc4)C3=O)nc(=O)c2c1,,CCO,,CC(=O)Cl,,val
US20060270691A1,C[Al](C)C.Clc1nc2ncnc-2c(-c2ccco2)[nH]1>>Cc1nc2ncnc-2c(-c2ccco2)[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCCl,,CCOC(C)=O,O,val
US20060167012A1,C[C@H]1CN(c2ccc(OC(F)(F)F)cc2)C[C@@H](C)N1S(=O)(=O)c1cccc2c1CC(C#N)C2.C[Si](C)(C)N=[N+]=[N-]>>C[C@H]1CN(c2ccc(OC(F)(F)F)cc2)C[C@@H](C)N1S(=O)(=O)c1cccc2c1CC(c1nnn[nH]1)C2,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US20150329560A1,Cc1ccc(S(=O)(=O)Cl)cc1.[N-]=[N+]=NCc1cccc(CO)n1>>Cc1ccc(S(=O)(=O)OCc2cccc(CN=[N+]=[N-])n2)cc1,,C1CCOC1,O,[Na+].[OH-],,val
US06352993B1,COCc1nc(Cl)nc(N2CCc3ccccc3C2C)c1C.Nc1ccc(F)cc1>>COCc1nc(Nc2ccc(F)cc2)nc(N2CCc3ccccc3C2C)c1C.Cl,,CN(C)C=O,,CCN(CC)CC,,val
US20060111375A1,BrCC1CO1.COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1O>>COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1OCC1CO1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20030191156A1,NO.O=c1ccoc2ccc(F)cc12>>Oc1ccc(F)cc1-c1ccno1,,CCO,,Cl,,val
US20150164074A1,COC(=O)c1nc(C(C)=O)c(F)c(N)c1Cl>>COC(=O)c1nc(C(C)O)c(F)c(N)c1Cl,,CO,,[BH4-].[Na+],,val
US20030018034A1,CCOC(=O)CN(CCOC(C)=O)c1ccc(F)cc1>>OCCN(CCO)c1ccc(F)cc1,,C1CCOC1,,O,[BH4-].[Li+],val
US20090203737A1,COC(=O)C1CN(C(=O)OC(C)(C)C)CC(C)(C)C1=O.O=C(Cl)c1ccc(F)cc1>>COC(=O)C1CN(C(=O)c2ccc(F)cc2)CC(C)(C)C1=O,,ClCCl,,CCN(CC)CC,Cl,val
US20100261755A1,COC(=O)C1CCN(C(=O)OC)C(CC2CCCCC2)C1>>COC(=O)N1CCC(C(=O)O)CC1CC1CCCCC1,,C1CCOC1,O,[Li+].[OH-],,val
US20100190831A1,CCOC(=O)/C=C/c1ccc(OCc2ccccc2)cc1OC(C)C>>CCOC(=O)CCc1ccc(O)cc1OC(C)C,[Pd],CCO,,[H][H],,val
US04035372,CC(=O)OC(C)=O.Nc1ccc(CN2CCC(C(c3ccccc3)c3ccccc3)CC2)cc1>>CC(=O)Nc1ccc(CN2CCC(C(c3ccccc3)c3ccccc3)CC2)cc1,,CC(=O)O,,,,val
US05432169,C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](SCCO)CC[C@@]43C)[C@@]1(O)CC[C@@H]2c1ccoc1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCCS[C@H]2CC[C@@]3(C)[C@H](CC[C@@H]4[C@@H]3CC[C@]3(C)[C@@H](c5ccoc5)CC[C@]43O)C2)cc1,,c1ccncc1,,CCOC(C)=O,O,val
US20090163488A1,CCOC(=O)N=C=S.Cc1cccnc1C(=O)Nc1cccc(Oc2ccc(N)nc2)c1>>CCOC(=O)NC(=S)Nc1ccc(Oc2cccc(NC(=O)c3ncccc3C)c2)cn1,,CS(C)=O,O,,,val
US20140024650A1,CC(=O)c1ccc(O)cc1.CC(C)(C)OC(=O)NC1CCOCC1CO>>CC(=O)c1ccc(OCC2COCCC2NC(=O)OC(C)(C)C)cc1,,Cc1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20120309788A1,CCCCBr.O[C@@H]1[C@@H](C(F)F)CNC[C@H]1O>>CCCCN1CC(O)C(O)C(C(F)F)C1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US04655816,CCOC(=O)c1c(Cl)cc(C(F)(F)F)nc1C(F)(F)F.O=[N+]([O-])c1ccc(O)cc1>>CCOC(=O)c1c(Oc2ccc([N+](=O)[O-])cc2)cc(C(F)(F)F)nc1C(F)(F)F,,CC(=O)CC(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20040192742A1,O=C(NC1CCCN(C(=O)OCc2ccccc2)CC1O)C(CS(=O)(=O)Cc1ccccc1)NC(=O)N1CCOCC1>>O=C1CN(C(=O)OCc2ccccc2)CCCC1NC(=O)C(CS(=O)(=O)Cc1ccccc1)NC(=O)N1CCOCC1,,CS(C)=O,,CCN(CC)CC,,val
US07732446B1,COc1cc2c(N)cnc(CNC(=O)OC(C)(C)C)c2cc1OC.O=C(N=C=S)c1ccccc1>>COc1cc2c(NC(N)=S)cnc(CNC(=O)OC(C)(C)C)c2cc1OC,,CC(C)=O,,,,val
US04202821,CC(C)Br.O=[N+]([O-])c1ccccc1S>>CC(C)Sc1ccccc1[N+](=O)[O-],,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090215780A1,CCOC(=O)C(Cc1ccccc1)C(=O)OCC.O=C(CBr)c1ccc(Br)cc1>>CCOC(=O)C(CC(=O)c1ccc(Br)cc1)(Cc1ccccc1)C(=O)OCC,,C1CCOC1,,O,[H-].[Na+],val
US20140371199A1,CC(C)(C)OC(=O)N1CCN(C2CCN(C(=O)c3ccc(-c4ccc5ncc(-c6ccc(C#N)cc6)n5c4)cc3)CC2)CC1>>N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)N5CCC(N6CCNCC6)CC5)cc4)cn23)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150210697A1,CC(C)(C)[Si](C)(C)O[C@@H]1CN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC[C@H]1N.CN(C)CCO.O=C(n1ccnc1)n1ccnc1>>CN(C)CCOC(=O)N[C@@H]1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@H]1O[Si](C)(C)C(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20130116443A1,BrP(Br)Br.O=[N+]([O-])c1ccc(F)c(CO)c1>>BrP(Br)Br.OCc1ccccc1,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US04696928,O=[N+]([O-])c1ccc(F)cc1F.c1ccc(CC2=NCCN2)cc1>>[O-][N+]1=C(c2ccccc2)C2=NCCN2c2cc(F)ccc21,,CC(C)O,,O=C([O-])[O-].[K+].[K+],,val
US20100029650A1,CC(C)(C)OC(=O)N1CCC(CO)CC1.CS(=O)(=O)c1ccc(-c2ccc(O)cc2)cn1>>CC(C)(C)OC(=O)N1CCC(COc2ccc(-c3ccc(S(C)(=O)=O)nc3)cc2)CC1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110028493A1,CCOC(=O)c1cnn(CC(=O)NCC(=O)c2cccc(C(F)(F)F)c2)c1>>CCOC(=O)c1cnn(Cc2ncc(-c3cccc(C(F)(F)F)c3)o2)c1,,O=P(Cl)(Cl)Cl,,O,,val
US08304419B2,COc1ccc2c3c(n(C(=O)OC(C)(C)C)c2c1)C(=O)NCC3.N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CBr)c2F)c1>>COc1ccc2c(c1)c1c(n2C(=O)OC(C)(C)C)C(=O)N(Cc2ccc(Cl)c(Oc3cc(Cl)cc(C#N)c3)c2F)CC1,,C1CCOC1,CCOC(C)=O,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20130079321A1,Cn1cc([N+](=O)[O-])c(Cl)n1.Oc1ccncc1>>Cn1ncc([N+](=O)[O-])c1N1CCC(O)CC1,,CCO,,CCN(C(C)C)C(C)C,,val
US20070293533A1,CCN(CC)S(F)(F)F.CCOC(=O)C#CC(C)(C)O>>CCOC(=O)C#CC(C)(C)F,,ClCCl,,,,val
US20130150364A1,CS(=O)(=O)Cl.N[C@H]1CCN([C@@H]2CC[C@@H](Oc3cc(-n4c(C(F)F)nc5ccccc54)nc(N4CCOCC4)n3)CC2)C1=O>>CS(=O)(=O)N[C@H]1CCN([C@@H]2CC[C@@H](Oc3cc(-n4c(C(F)F)nc5ccccc54)nc(N4CCOCC4)n3)CC2)C1=O,,ClCCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20110195954A1,O=C(O)c1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)ncn1.O=[N+]([O-])c1ccc2c(c1)CCN2>>O=C(c1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)ncn1)N1CCc2cc([N+](=O)[O-])ccc21,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20060287363A1,C[C@H]1C[C@@H](Nc2cccc(NC(=O)c3ccc(F)cc3Cl)c2)CCN1C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)Cl)cc1>>C[C@H]1C[C@@H](Nc2cccc(NC(=O)c3ccc(F)cc3Cl)c2)CCN1.Cl,,CO,Cc1ccccc1,[Cl-].[NH4+],,val
US20040110764A1,CC(=O)c1ccc(C#N)cc1.C[S+](C)C>>CC1(c2ccc(C#N)cc2)CO1,,CS(C)=O,,[H-].[Na+],,val
US20110092526A1,COC(=O)C12CC3CC(C1)C(NC(=O)c1cnc(N[C@H]4CCOC4)nc1C1CCCC1)C(C3)C2>>O=C(NC1C2CC3CC1CC(C(=O)O)(C3)C2)c1cnc(N[C@H]2CCOC2)nc1C1CCCC1,,CO,,[Na+].[OH-],,val
US05248831,C=CCBr.CCOC(=O)CC(=O)COC1CCCCC1>>C=CCC(C(=O)COC1CCCCC1)C(=O)OCC,,CCO,,[Na],,val
US20110288067A1,CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Oc3ccc4[nH]ccc4c3)nc12>>CC(C)NC(=O)c1c[nH]c2ncc(Oc3ccc4[nH]ccc4c3)nc12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110257151A1,COC(=O)c1cc(N)ccc1Cl.O=Cc1cccc(Br)c1>>COC(=O)c1cc(N=Cc2cccc(Br)c2)ccc1Cl,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,,,val
US20070259821A1,O=C(O)c1cc(I)ccc1Br>>OCc1cc(I)ccc1Br,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20080153836A1,COC(=O)c1cc(-c2ccnn2C(C)C)c(C(C)(F)F)cc1N.CS(=O)(=O)NN.ClCCl.[OH-]>>CC(C)n1nccc1-c1cc2c(=O)n(NS(C)(=O)=O)c(=O)[nH]c2cc1C(C)(F)F,,ClCCl,,CCN(CC)CC,,val
US20080255122A1,CCCCN1C(=O)C(Nc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3)=C(c2ccccc2)S1(=O)=O>>CCCCN1C(=O)C(Nc2ccc3c(c2)CCNC3)=C(c2ccccc2)S1(=O)=O,,ClCCl,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],,val
US05952382,COCCOCOc1cc2ccc(-c3ccc(C(=O)O)cc3)cc2cc1C12CC3CC(CC(C3)C1)C2>>COCCOCOc1cc2ccc(-c3ccc(CO)cc3)cc2cc1C12CC3CC(CC(C3)C1)C2,,C1CCOC1,,B,Cl,val
US04282242,COC(=O)c1c[nH]c(C(=O)c2ccccc2)c1>>O=C(O)c1c[nH]c(C(=O)c2ccccc2)c1,,CCO,,[Na+].[OH-],,val
US20050020605A1,CCON=C(c1ccc(Br)cc1)C1CCN(C2(C)CCNCC2)CC1.O=C(O)c1ccc2cnccc2n1>>CCON=C(c1ccc(Br)cc1)C1CCN(C2(C)CCN(C(=O)c3ccc4cnccc4n3)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020161041A1,CCNC(=O)C1CCCC(c2ccc(OCOC)cc2OCOC)C1>>CCNC(=O)C1CCCC(c2ccc(O)cc2O)C1,,CO,,,,val
US05084456,Cc1ccc(O)cn1.O=[N+]([O-])O>>Cc1ccc(O)c([N+](=O)[O-])n1,,O=S(=O)(O)O,,,,val
US20070281933A1,CNC.NC(=O)c1cc(Br)cc2c(C3CCN(S(=O)(=O)CCCCl)CC3)n[nH]c12>>CN(C)CCCS(=O)(=O)N1CCC(c2n[nH]c3c(C(N)=O)cc(Br)cc23)CC1,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20030105336A1,N.O=C(Cl)c1ccc(-c2nn(Cc3ccccc3)c3ccccc23)o1>>NC(=O)c1ccc(-c2nn(Cc3ccccc3)c3ccccc23)o1,,C1CCOC1,,,,val
US03932452,ClCc1c(Cl)cccc1Cl.O=C1NCCN1>>O=C1NCCN1Cc1c(Cl)cccc1Cl,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100311965A1,Cc1c(F)ccc2cnc(Nc3ccc4cn[nH]c4c3)nc12.OCCN1CCOCC1>>Cc1c(OCCN2CCOCC2)ccc2cnc(Nc3ccc4cn[nH]c4c3)nc12,,O,,CN(C)C=O,[H-].[Na+],val
US20090054465A1,CC(C)(C)OC(=O)N[C@@H]1CCNC1.ICC12CCC(CC1)O2>>CC(C)(C)OC(=O)N[C@@H]1CCN(CC23CCC(CC2)O3)C1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070066618A1,CCOC(=O)C(C)c1ccc(N)cc1>>CC(CO)c1ccc(N)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160075692A1,CCS(=O)(=O)Cl.O=C1N(c2cccc3c2cnn3-c2ccccc2F)CCN1C1CNC1>>CCS(=O)(=O)N1CC(N2CCN(c3cccc4c3cnn4-c3ccccc3F)C2=O)C1,,c1ccncc1,,CCN(C(C)C)C(C)C,,val
US20130217668A1,COc1ccc(COc2ccc([N+](=O)[O-])c(N[C@H]3CC[C@@H](C(=O)NC(C)C)CC3)c2)cc1>>COc1ccc(COc2ccc(N)c(N[C@H]3CC[C@@H](C(=O)NC(C)C)CC3)c2)cc1,[Zn],CO,,CC(=O)O,,val
US20120028953A1,Cc1ccc(N)nn1.O=C(Oc1ccc([N+](=O)[O-])cc1)N1CC(Oc2ccc(-c3ccccc3F)cn2)C1>>Cc1ccc(NC(=O)N2CC(Oc3ccc(-c4ccccc4F)cn3)C2)nn1,,CN(C)C=O,,[H-].[Na+],,val
US06054470,COc1ccc(Cn2ncc(C)c(NC(=O)OCc3ccccc3)c2=O)cc1>>COc1ccc(Cn2ncc(C)c(N)c2=O)cc1,[Pd],CCO,CCOC(C)=O,,,val
US20070238723A1,C=O.CC(=O)OC1CCC(C(=O)NCc2cc(C(F)(F)F)ccc2O)(C(C)OC(C)=O)C1>>CC(=O)OC1CCC(C(=O)N2COc3ccc(C(F)(F)F)cc3C2)C1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140206681A1,C[C@@H]1OC(=O)N2C[C@H](c3nc(Br)c4c(N)nccn34)CC[C@@H]12>>C[C@H](O)[C@@H]1CC[C@@H](c2nc(Br)c3c(N)nccn23)CN1,,CCO,,[K+].[OH-],,val
US05801183,COc1cccc(CC(=O)Nc2cc(Cl)c(Cl)cc2[N+](=O)[O-])c1>>COc1cccc(-c2c(=O)[nH]c3cc(Cl)c(Cl)cc3[n+]2[O-])c1,,CCO,,[Br-].[K+],,val
US20160145289A1,COC(=O)c1cccc(-c2ccc(O[C@H]3O[C@@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(C)c2)c1>>Cc1cc(-c2cccc(C(=O)O)c2)ccc1O[C@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@H]1O,,CO,,[Na+].[OH-],,val
US05608064,I.Nc1nc(Cl)c2nc[nH]c2n1>>Nc1nc(I)c2nc[nH]c2n1,,O,,,,val
US04656179,C=O.COc1cc2c(cc1OC)C(CCO)=NCC2>>COc1cc2c(cc1OC)C(C(CO)CO)=NCC2,,CO,,,,val
US04377580,CCOC=C(C(=O)OCC)C(=O)OCC.CN1CCN(c2ccc3ncnc(N)c3c2)CC1>>CCOC(=O)C(=CNc1ncnc2ccc(N3CCN(C)CC3)cc12)C(=O)OCC,,CC(C)CO,,,,val
US20040180934A1,COC(=O)C1Cn2c(cc3c(Br)cc(F)cc32)C1=O>>O=C1CCn2c1cc1c(Br)cc(F)cc12,,CCO,,Cl,O,val
US04374137,COc1cc(C(=O)Cl)cc(OC)c1OC.c1ccc2c(c1)CC1(CNCc3ccccc31)O2>>COc1cc(C(=O)N2Cc3ccccc3C3(Cc4ccccc4O3)C2)cc(OC)c1OC,,ClCCl,,CCN(CC)CC,,val
US20090062251A1,CC1CCNCC1.O=C(O)c1ccc2[nH]c3c(c2c1)CC(C1CCCCC1)CC3>>CC1CCN(C(=O)c2ccc3[nH]c4c(c3c2)CC(C2CCCCC2)CC4)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05726187,CCCCN1CCC(CN)CC1.Cc1nc2cc(Cl)cc(C(=O)O)c2o1>>CCCCN1CCC(CNC(=O)c2cc(Cl)cc3nc(C)oc23)CC1,,CCN(CC)CC,,O=C(Cl)C(=O)Cl,,val
US04181802,CC(N)c1cccnc1.O=[N+]([O-])c1cc(Cl)ccc1Cl>>CC(Nc1ccc(Cl)cc1[N+](=O)[O-])c1cccnc1.Cl,,CCCCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20100016352A1,COCCl.COc1ccc(-c2oc3cc(O)cc(O)c3c(=O)c2OC)cc1OC>>COCOc1cc(O)c2c(=O)c(OC)c(-c3ccc(OC)c(OC)c3)oc2c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,Cl,val
US05420275,CCOC(=O)c1c(Cl)nc(-c2ccc([N+](=O)[O-])cc2)c([N+](=O)[O-])c1C(=O)OCC>>CCOC(=O)c1c(Cl)nc(-c2ccc(N)cc2)c(N)c1C(=O)OCC,,CCO,,Cl,,val
US20090143352A1,COC(=O)Cl.COc1ccccc1-c1cn(S(=O)(=O)c2ccc(C)cc2)c2ncc(B3OC(C)(C)C(C)(C)O3)cc12.Nc1ccc(I)cc1C(=O)O>>COC(=O)Nc1ccc(-c2cnc3c(c2)c(-c2ccccc2OC)cn3S(=O)(=O)c2ccc(C)cc2)cc1C(=O)O,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])[O-].[K+].[K+],val
US05134152,C[C@H]1[C@@H](C)O[C@@]1(Cn1cncn1)c1ccc(Cl)cc1.O=[N+]([O-])O>>C[C@H]1[C@@H](C)O[C@@]1(Cn1cncn1)c1ccc(Cl)cc1.O=[N+]([O-])O,,CCOCC,CO,,,val
US20100137302A1,N[C@@H](Cc1c[nH]c2cc(F)ccc12)C(=O)O>>NC(CO)Cc1c[nH]c2cc(F)ccc12,,C1CCOC1,,,,val
US20030229125A1,CC=CC(=O)Cl.Cn1nc(C(F)(F)F)cc1Oc1cccc(CN)n1>>CC=CC(=O)C(N)c1cccc(Oc2cc(C(F)(F)F)nn2C)n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130338140A1,CC(C)Nc1ncc2c(n1)CN(C(=O)NC(CCNC(=O)OC(C)(C)C)c1ccc(Cl)c(Cl)c1)CC2>>CNCCC(NC(=O)N1CCc2cnc(NC(C)C)nc2C1)c1ccc(Cl)c(Cl)c1,,C1CCOC1,,,,val
US20150119405A1,CC(C)(C)OC(=O)N1CC[C@@H](N)[C@H](O)C1.O=C(OCc1ccccc1)ON1C(=O)CCC1=O>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)OCc2ccccc2)[C@H](O)C1,,ClCCl,,CCN(CC)CC,,val
US20110218197A1,CC(C)(C)c1cc(C(=O)Nc2nc(-c3ccccc3C(F)(F)F)cc(Cl)c2[N+](=O)[O-])on1>>CC(C)(C)c1cc(C(=O)Nc2nc(-c3ccccc3C(F)(F)F)cc(Cl)c2N)on1,[Fe],CCO,O,[Cl-].[NH4+],,val
US07728155B2,Cc1ccc(S(=O)(=O)Cl)cc1.OCC(O)Cc1c(Cl)cc2c(c1OCc1ccccc1)CCC2>>Cc1ccc(S(=O)(=O)OCC(O)Cc2c(Cl)cc3c(c2OCc2ccccc2)CCC3)cc1,,c1ccncc1,,,,val
US05866564,O=C(O)CS.O=C(OCCN1CCN(C(=O)[C@@H]2C[C@@H](O)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)CC1)OCc1ccc([N+](=O)[O-])cc1>>O=C(OCCN1CCN(C(=O)[C@@H]2C[C@H](S)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)CC1)OCc1ccc([N+](=O)[O-])cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100234365A1,CS(=O)(=O)OC[C@@H]1OC(=O)N(c2ccc(Cl)cc2)[C@H]1c1cc(F)cc(F)c1.Cc1ccc(-c2nn[nH]n2)cn1>>Cc1ccc(-c2nnn(C[C@@H]3OC(=O)N(c4ccc(Cl)cc4)[C@H]3c3cc(F)cc(F)c3)n2)cn1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130190314A1,CC(C)(C)OC(=O)N1CCN(c2ccc3nc(-c4cccs4)cn3n2)CC1.CCOC(=O)Cl.c1ccncc1>>CCOC(=O)N1C=CC(c2c(-c3cccs3)nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)nn23)C=C1,,ClCCl,,O,,val
US20140024694A1,C[C@@H](n1ccc2c(C(F)(F)F)c(C#N)ccc21)C(C)(C)O>>C[C@@H](N1CCc2c1ccc(C#N)c2C(F)(F)F)C(C)(C)O,,O=C(O)C(F)(F)F,,[BH3-]C#N.[Na+],,val
US20120088755A1,Cc1cc(O)cc2[nH]c(C3CC3)nc12.Clc1cc(Cl)ncn1>>Cc1cc(Oc2cc(Cl)ncn2)cc2[nH]c(C3CC3)nc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050014210A1,CC(Cc1ccc2c(c1)OC(CNC(=O)OCc1ccccc1)O2)N(C)C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CNC(C)Cc1ccc2c(c1)OC(CNC(=O)OCc1ccccc1)O2.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20040254183A1,Cc1sc(NC(=O)OC(C)(C)C)nc1-c1c2c(=O)n(C)c(=O)n(CC3CC3)c2nn1Cc1ccnc2ccc(Cl)cc12>>Cc1sc(N)nc1-c1c2c(=O)n(C)c(=O)n(CC3CC3)c2nn1Cc1ccnc2ccc(Cl)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US05580866,NO.S=C1CSc2ccccc2CN1>>ON=C1CSc2ccccc2CN1,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20090221555A1,COc1ccc(C(N)=O)cc1N.Clc1ncc(Cl)c(Cl)n1>>COc1ccc(C(N)=O)cc1Nc1nc(Cl)ncc1Cl,,C1CCOC1,,,,val
US20160185751A1,NCC1CCN(CCCn2ccnn2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>NCC1CCN(CCCn2ccnn2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O,,CC(C)=O,,,,val
US20130079323A1,CCc1[nH]c2nc(Sc3cccnc3)nc(NC[C@H](C)O)c2c1C=O>>CCc1[nH]c2nc(Sc3cccnc3)nc(NC[C@H](C)O)c2c1CO,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20120035167A1,O=C1CCC(n2ccc3cc(Br)ccc32)CC1>>OC1CCC(n2ccc3cc(Br)ccc32)CC1,,CO,,[BH4-].[Na+],,val
US20140303164A1,Cn1nc(NS(=O)(=O)C(F)(F)F)c2c(Cl)ccc(-c3ccc(C#CC(C)(C)O)nc3[C@H](Cc3cc(F)cc(F)c3)NC(=O)OC(C)(C)C)c21>>Cn1nc(NS(=O)(=O)C(F)(F)F)c2c(Cl)ccc(-c3ccc(C#CC(C)(C)O)nc3[C@@H](N)Cc3cc(F)cc(F)c3)c21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140315889A1,COC(=O)c1ccc(CBr)cc1.O=C1NCCc2[nH]c3ccc(F)cc3c21>>COC(=O)c1ccc(Cn2c3c(c4cc(F)ccc42)C(=O)NCC3)cc1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06610707B1,O=C(O)c1ccco1.O=C1c2ccccc2C(=O)N1CO>>O=C(O)c1ccc(CN2C(=O)c3ccccc3C2=O)o1,,O=S(=O)(O)O,,,,val
US20050214331A1,C1CCOC1.CCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCC)NC(=O)[C@@H](CCCC)NC(=O)[C@@H](CCCC)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)N[C@H](CCCC)C(=O)N[C@H](CCCC)C(=O)NCC(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O.O=C(O)C(F)(F)F.Oc1ccccc1>>CCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)OC(C)(C)C)C(=O)N[C@H](CCCC)C(=O)N[C@H](CCCC)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCC)C(=O)N[C@H](CCCC)C(=O)N[C@H](CCCC)C(=O)NCC(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O,,C1CCOC1,Cc1ccccc1,O=C(O)C(F)(F)F,,val
US04487929,CC(O)=S.COC(=O)C1C=CCN2C(=O)C(CCI)(Cc3ccccc3)C(=O)N12>>COC(=O)C1C=CCN2C(=O)C(CCSC(C)=O)(Cc3ccccc3)C(=O)N12,,CC(C)=O,,CC(=O)[O-].[K+],,val
US20090082358A1,CC1Cc2ccc(Br)nc2C(c2ccc(C(F)(F)F)cc2)N1Cc1ccccc1>>CC1=Cc2cccnc2C(c2ccc(C(F)(F)F)cc2)N1Cc1ccccc1,,CO,,[BH4-].[Na+],,val
US20160016948A1,CC(C)(C)OC(=O)N1CCC(O)C(C)(F)C1.Cl>>CC1(F)CNCCC1O.Cl,,CCOCC,,,,val
US05122523,CSCC(O)C1OC(C)(C)N(C(=O)OC(C)(C)C)C1CC1CCCCC1.Cl>>CSCC(O)C(O)C(N)CC1CCCCC1.Cl,,C1COCCO1,,,,val
US20050096336A1,C[Mg]Cl.Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1C=O>>Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1C(C)O,,C1CCOC1,,,,val
US20090298807A1,CC(C)(C)OC(=O)N(CCSCCCCCCBr)C[C@H](O)c1ccc(O)c2[nH]c(=O)sc12.O=C(N1CCOC2(CCNCC2)C1)C(F)(F)F>>CC(C)(C)OC(=O)N(CCSCCCCCCN1CCC2(CC1)CN(C(=O)C(F)(F)F)CCO2)C[C@H](O)c1ccc(O)c2[nH]c(=O)sc12,,CC#N,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20090156603A1,N#Cc1ccccc1F.Oc1cccnc1Cl>>N#Cc1ccccc1Oc1cccnc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20030153568A1,CCN1CN(C)CN(c2nc3ccc([N+](=O)[O-])c(CC#N)c3s2)C1=O>>N#Cc1onc2ccc3ncsc3c12,,CN(C)C=O,,CCN(CC)CC,C[Si](C)(C)Cl,val
US20120316147A1,CCC(CC)(NC(=O)OC(C)(C)C)C(=O)N(C)C.Cl>>CCC(N)(CC)C(=O)N(C)C.Cl,,CCOC(C)=O,,,,val
US20070149533A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1ccc(N)cc1C(F)(F)F>>CC(C)(C)OC(=O)NCc1ccc(N)cc1C(F)(F)F,,C1CCOC1,,,,val
US04233231,CCCCCC(C)=O.CCCC[Sn](/C=C/[Sn](CCCC)(CCCC)CCCC)(CCCC)CCCC>>CCCCCC(C)(O)/C=C/[Sn](CCCC)(CCCC)CCCC,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US05556864,CN1CCCC1CCOc1ccccc1CCc1ccccc1Cl.Cl>>CN1CCCC1CCOc1ccccc1CCc1ccccc1Cl.Cl,,C1COCCO1,ClCCl,,,val
US20100292206A1,CC(C)(C)OC(=O)N1CC(Sc2ccccc2C(C)(C)C)C1.Cl>>CC(C)(C)c1ccccc1SC1CNC1.Cl,,C1COCCO1,,,,val
US20100029753A1,COCN(c1ccsc1C(=O)OC)S(=O)(=O)c1ccc(C(C)(C)C)cc1-c1cncnc1>>COC(=O)c1sccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1-c1cncnc1,,C1CCOC1,,Cl,,val
US20030216406A1,COCCNS(=O)(=O)c1ccc(N)cc1.N#Cc1cnc(Cl)nc1NC1CC1>>COCCNS(=O)(=O)c1ccc(Nc2ncc(C#N)c(NC3CC3)n2)cc1,,CCC(C)O,,,,val
US20160207915A1,COc1cc(S(C)(=O)=O)ccc1Nc1nc2ccc(Cl)cn2n1.O=C(Cl)OCCl>>COc1cc(S(C)(=O)=O)ccc1N(C(=O)OCCl)c1nc2ccc(Cl)cn2n1,,C1CCOC1,,[H-].[Na+],,val
US20070249599A1,Cc1nc2ccc(CO)cc2o1>>Cc1nc2ccc(C=O)cc2o1,,CCOC(C)=O,ClCCl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20160107997A1,CC(=O)OC(OC(C)=O)C(=O)Cl.CN(C)CCNCc1ccccc1C(F)(F)F>>CC(=O)OC(OC(C)=O)C(=O)N(CCN(C)C)Cc1ccccc1C(F)(F)F,,ClCCl,,O,,val
US05254558,C=CCn1c(-c2ccccc2)ncc(C(=O)O)c1=O.OCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>C=CCn1c(-c2ccccc2)ncc(NC(=O)OCc2ccccc2)c1=O,,C1COCCO1,,CCN(CC)CC,,val
US20130316943A1,CC1(C)OB(O)c2cc([N+](=O)[O-])ccc21>>CC1(C)OB(O)c2cc(N)ccc21,[Zn],CO,,Cl,ClCCl,val
US20080275018A1,CC(C)(C)OC(=O)NCCNC(=O)[C@H](CCCN)NC(=O)OC(C)(C)C.CN1C(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)Cc2cc(ccc2O)-c2cccc(c2)C[C@H]1C(=O)O>>CN1C(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)Cc2cc(ccc2O)-c2cccc(c2)C[C@H]1C(=O)NCCC[C@H](NC(=O)OC(C)(C)C)C(=O)NCCNC(=O)OC(C)(C)C,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20030125371A1,Cn1ccc2ccc(-c3ccc(C(C)(C)C)cc3)cc21.O=C=O>>Cn1cc(C(=O)O)c2ccc(-c3ccc(C(C)(C)C)cc3)cc21,,C1CCOC1,,[Li]CCCC,,val
US20060142265A1,CC(C)Oc1c(Cl)cccc1CO>>CC(C)Oc1c(Cl)cccc1C=O,O=[Mn]=O,c1ccccc1,,,,val
US20160052890A1,Clc1ccc2oc(Cl)nc2c1.NCC(=O)Nc1ccc(Oc2cccnc2)cc1>>O=C(CNc1nc2cc(Cl)ccc2o1)Nc1ccc(Oc2cccnc2)cc1,,ClC(Cl)Cl,,,,val
US04326996,CC(C)=CCC1C(C)=CC(=O)CC1C>>CC(C)=CCC1C(C)CC(=O)CC1C,[Pd],[K+],[OH-],[H][H],,val
US20060270670A1,CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CNC.ClCCl>>CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CNC.Cl,,CO,ClCCl,,,val
US20070197512A1,COC(=O)CCN1C(=O)C(C(C)C)Oc2ccc(Cl)cc21>>CC(C)C1Oc2ccc(Cl)cc2N(CCC(=O)O)C1=O,,CO,,[Na+].[OH-],,val
US20080096881A1,C1CCNC1.COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC1CCN(C(=O)NCCCl)CC1>>COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC1CCN(C(=O)NCCN2CCCC2)CC1,,CC(=O)N(C)C,,[I-].[K+],,val
US05843941,BrBr.O=C1CC=C(c2ccccc2Cl)c2cc(Cl)ccc2N1>>O=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)=CC1Br,,ClC(Cl)(Cl)Cl,,,,val
US20130116235A1,C[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c6c(c(F)c5C4=O)CCCC6)c3C=O)cn(C)c2=O)nc1>>C[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c6c(c(F)c5C4=O)CCCC6)c3CO)cn(C)c2=O)nc1,,CO,,[BH4-].[Na+],,val
US20120122846A1,COC(=O)C(C)Cc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>CC1Cc2ccc(N)cc2NC1=O,[Pd],CC(C)(C)O,,,,val
US20090023763A1,CCOC(CC)(OCC)OCC.Nc1cc(-c2ccncc2)c(-c2cccc(F)c2)nc1N>>CCc1nc2cc(-c3ccncc3)c(-c3cccc(F)c3)nc2[nH]1,,CC(=O)O,,,,val
US20090203633A1,CC(=O)OC[C@H]1O[C@@H](Oc2n[nH]c(C(C)C)c2Cc2ccc(OCCCN)cc2C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.N=C(NC(=O)OCc1ccccc1)n1cccn1>>CC(=O)OC[C@H]1O[C@@H](Oc2n[nH]c(C(C)C)c2Cc2ccc(OCCCNC(N)=NC(=O)OCc3ccccc3)cc2C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,C1CCOC1,,,,val
US20050107354A1,CCOC(=O)COc1cc(C(C)C)ccc1CCN(Cc1csc(C)n1)S(=O)(=O)c1cc(C(=N)N)ccc1O>>Cc1nc(CN(CCc2ccc(C(C)C)cc2OCC(=O)O)S(=O)(=O)c2cc(C(=N)N)ccc2O)cs1,,CCO,,[Na+].[OH-],,val
US20090203676A1,CSc1ccc(F)cc1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ccc(F)cc1,,ClCCl,,,,val
US20130190315A1,FC(F)(F)Cn1nccc1-c1ncccc1CCl.O=Cc1c(O)cccc1O>>O=Cc1c(O)cccc1OCc1cccnc1-c1ccnn1CC(F)(F)F,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100137250A1,CCS(=O)(=O)c1ccc(Cc2c(C)c(C(=O)OC)cc3ccc(F)cc23)cc1>>CCS(=O)(=O)c1ccc(Cc2c(C)c(CO)cc3ccc(F)cc23)cc1,,C1CCOC1,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20040171881A1,CCCC(=O)C1=C(N)C=CC(O)(C(=O)OC)C1.O>>CCCC(=O)C1CC(O)(C(=O)OC)C=CC1=O,,C1CCOC1,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080146565A1,CCOC(=O)[C@@H]1CC[C@@H](N)CC1.CS(=O)(=O)c1nccc(-n2ncc3ccccc32)n1>>CCOC(=O)[C@@H]1CC[C@@H](Nc2nccc(-n3ncc4ccccc43)n2)CC1,,C1CCOC1,,,,val
US20060122256A1,CCOC(=O)c1csc(COc2ccc(I)cc2)n1.OB(O)c1ccsc1>>O=C(O)c1csc(COc2ccc(-c3ccsc3)cc2)n1,,C1COCCO1,,,,val
US20050096337A1,CCCCc1nc(-c2ccc(C(F)(F)F)cc2)ncc1COc1ccc(OC(C)(C)C(=O)OCC)c(C)c1>>CCCCc1nc(-c2ccc(C(F)(F)F)cc2)ncc1COc1ccc(OC(C)(C)C(=O)O)c(C)c1,,C1CCOC1,CCOCC,[Li+].[OH-],,val
US04051173,CCOC(=O)Cc1ccccc1Oc1ccc(C2CCN(C)c3ccccc32)cc1>>CN1CCC(c2ccc(OC(CO)c3ccccc3)cc2)c2ccccc21,,C1CCOC1,O,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20150210666A1,CC#CCOc1ccc(C[C@H](N)C(=O)OC)cc1.CCCCCCCSCCCCCC/C=C/[C@H](C(=O)N1C(=O)SC(c2ccccc2)(c2ccccc2)[C@@H]1C(C)C)[C@@](O)(CCOC)C(=O)[O-]>>CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCSCCCCCCC)[C@@](O)(CCOC)C(=O)OC(C)(C)C)C(=O)OC)cc1,,ClCCl,,,,val
US20040058945A1,CC(=O)Nc1ccc2nc(-c3ccc(C4CCCCC4)cc3)cc(N)c2c1>>Nc1ccc2nc(-c3ccc(C4CCCCC4)cc3)cc(N)c2c1,,Cl,,[Na+].[OH-],,val
US20150284395A1,C#CCOC(=N)c1cnn2c(=O)cc(-c3ccc4[nH]nnc4c3)[nH]c12>>Cc1coc(-c2cnn3c(=O)cc(-c4ccc5[nH]nnc5c4)[nH]c23)n1,,Cc1ccccc1C,,CCN(C(C)C)C(C)C,Cl,val
US20080214545A1,CC(C)(C)c1cc(NC(=O)Oc2ccccc2)n(-c2cccc(OCCCO)c2)n1.Nc1ccc(Oc2ccncc2)cc1>>CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccncc3)cc2)n(-c2cccc(OCCCO)c2)n1,,C1CCOC1,,,,val
US20060270706A1,COC(=O)Cn1nncc1/C=C1\CN(C(c2ccccc2)(c2ccccc2)c2ccccc2)CCC1=O>>COC(=O)Cn1nncc1/C=C1\CN(C(c2ccccc2)(c2ccccc2)c2ccccc2)CCC1O,,C1CCOC1,,[BH4-].[Na+],,val
US20080085898A1,CC(C)(C)OC(=O)Nc1ccc(F)cc1Nc1ncc([N+](=O)[O-])c(SC#N)n1.O=C(O)C(F)(F)F>>N#CSc1nc(Nc2ccc(F)cc2N)ncc1[N+](=O)[O-].O=C(O)C(F)(F)F,,ClCCl,,,,val
US20050197337A1,C1CCNC1.CCCCCCSc1nc(C)cc(C=O)n1>>CCCCCCSc1nc(C)cc(CN2CCCC2)n1,,CC(=O)O,CCO,[BH3-]C#N.[Na+],,val
US20120302540A1,CC(C)N1CC(c2ccc(F)cc2)C2(CCCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)NC(=O)OC(C)(C)C)C2)C1=O>>CC(C)N1CC(c2ccc(F)cc2)C2(CCCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C2)C1=O,,ClCCl,,CO,O=C(O)C(F)(F)F,val
US20100311748A1,BrCc1ccccn1.COC(=O)c1ccc(O)cn1>>COC(=O)c1ccc(OCc2ccccn2)cn1,,CC#N,,Br,O=C([O-])[O-].[K+].[K+],val
US20040097590A1,CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccc2ncccc2c1.Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccccc3)oc2C)cc1>>Cc1oc(-c2ccccc2)nc1CCOc1ccc(CC(C)(Oc2ccc3ncccc3c2)C(=O)O)cc1,,CCO,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20040121965A1,CC(C)(C)c1ccc(C(C)(C)C(=O)C(=O)O)cc1.CN>>CN[C@H](C(=O)O)C(C)(C)c1ccc(C(C)(C)C)cc1,,C1CCOC1,,,,val
US20070219198A1,CC(C)(C)OC(=O)N1CCC(O)CC1.Oc1c(Cl)cccc1Cl>>CC(C)(C)OC(=O)N1CCC(Oc2c(Cl)cccc2Cl)CC1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070027178A1,Cc1ccc(Sc2c(Cl)cccc2NN)cc1.Cl.O=C1CCNCC1>>Cc1ccc(Sc2c(Cl)ccc3c4c([nH]c23)CCNC4)cc1.Cl,,OCC(F)(F)F,,Cl,O,val
US20160221946A1,Cc1ccc(Cc2ccc3c(CN(C)C(=O)OC(C)(C)C)c[nH]c3c2)c(Cl)c1.O=S(=O)(Cl)c1cccc(F)c1>>Cc1ccc(Cc2ccc3c(CN(C)C(=O)OC(C)(C)C)cn(S(=O)(=O)c4cccc(F)c4)c3c2)c(Cl)c1,,CN(C)C=O,,O,[H-].[Na+],val
US05708177,COCCOC(=O)c1c(C)nc(C)c(C(=O)OC(C)C)c1-c1cccc(C#N)c1Cl>>COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc(C#N)c1Cl,,CO,,,,val
US20100190764A1,COC(=O)C1CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1>>O=C(O)C1CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1,,CO,O,[K+].[OH-],,val
US20060229343A1,CON=C1C[C@@H](C(N)=O)N(C(=O)c2ccc(-c3ccccc3)cc2)C1>>CON=C1C[C@@H](C#N)N(C(=O)c2ccc(-c3ccccc3)cc2)C1,,c1ccncc1,,Cc1ccc(S(=O)(=O)Cl)cc1,,val
US20020052512A1,COC(=O)c1ccc(C(=O)ON2C(=O)CCC2=O)cc1Cl.NCc1cccc(O)c1>>COC(=O)c1ccc(C(=O)NCc2cccc(O)c2)cc1Cl,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20070282101A1,CN(C)C=Nc1cc(/C=C/N(C)C)c([N+](=O)[O-])cn1>>CN(C)C=Nc1cc2cc[nH]c2cn1,[Pd],CCO,,,,val
US20020165253A1,CI.O=C(NCc1ccc(Cl)cc1)c1cnc2c(I)cc(CC3CCOCC3)cc2c1O>>Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CC3CCOCC3)cc(I)c21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04990517,C=C(C)CN(CC(OC)OC)C(=O)OCC>>C=C(C)CN(CC=O)C(=O)OCC,,CC(C)=O,O,,,val
US20050288314A1,CC1(C)[C@H]2CC[C@H](CO)[C@@H]1C2.N#Cc1c(F)cccc1F>>CC1(C)[C@H]2CC[C@H](COc3ccc(F)c(C#N)c3)[C@@H]1C2,,CN(C)C=O,,[H-].[Na+],,val
US20070111984A1,Cc1ncnn1-c1cc(F)ccc1Br.N#C[Cu]>>Cc1ncnn1-c1cc(F)ccc1C#N,,CN1CCCC1=O,,,,val
US20100311750A1,CC(=O)OC(C)=O.COC(=O)[C@@H]1CC[C@@H](CN)CC1>>COC(=O)[C@@H]1CC[C@@H](CNC(C)=O)CC1,,c1ccncc1,,Cl,Cl,val
US20010002397A1,CC(=O)OC(C)=O.CC(C)[C@@H](C)/C=C/[C@@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C>>CC(=O)O[C@H]1CC[C@@]2(C)C(=CC=C3[C@@H]4CC[C@H]([C@H](C)/C=C/[C@H](C)C(C)C)[C@@]4(C)CC[C@@H]32)C1,,c1ccncc1,,O,,val
US20130203768A1,CN.Cc1cc(Cl)c(C(=O)O)c(C)n1>>CNC(=O)c1c(Cl)cc(C)nc1C,CN(C)C=O,ClCCl,,C1CCOC1,O=C(Cl)C(=O)Cl,val
US20160152624A1,CC(=O)OC(C)(C)C.CN[C@@H]1CCCC[C@H]1NC.CS(C)=O.CSc1nc(Cl)nc2[nH]ccc12>>CSc1nc(Cl)nc2c1ccn2-c1ccc(CC(=O)OC(C)(C)C)cc1,[Cu]I,CS(C)=O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US04166119,O=C(Cl)C1CCC1.c1ccc2c(c1)CC1(CCNCC1)O2>>O=C(C1CCC1)N1CCC2(CC1)Cc1ccccc1O2,,ClC(Cl)Cl,,O=C([O-])[O-].[K+].[K+],,val
US20160095858A1,Cc1cc(C)c(Oc2nc(C)c(C#N)cc2C(=O)NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c(C)c1>>Cc1cc(C)c(Oc2nc(C)c(C#N)cc2C(=O)NS(=O)(=O)c2cccc(N)c2)c(C)c1,[Pd],CO,,[H][H],,val
US20090181942A1,CC(C)OC(=O)C[C@H]1S[C@H](c2ccccc2Cl)c2cc(Cl)ccc2NC1=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)OC(=O)C[C@H]1S[C@H](c2ccccc2Cl)c2cc(Cl)ccc2NC1=S,,Cc1ccccc1,,,,val
US20150094328A1,CC(C)(C)OC(=O)n1cc(C(=O)N[C@H]2CCCC[C@@H]2O)c2nc(C#N)ccc21.FC(F)(F)Oc1ccc(CBr)cc1>>O=C(N[C@H]1CCCC[C@@H]1O)c1cn(Cc2ccc(OC(F)(F)F)cc2)c2cccnc12,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030212276A1,COCCOc1ccc2c(=O)c(C#N)c[nH]c2c1.O=S(Cl)Cl>>COCCOc1ccc2c(Cl)c(C#N)cnc2c1,,CN(C)C=O,,,,val
US20040180884A1,COC(=O)c1c(Cl)cccc1CBr.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1c(Cl)cccc1C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-],,CC#N,,,,val
US20150353533A1,CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)COc2ccc(-c3n[nH]c(=O)o3)cc21.Cl>>CN1C(=O)[C@@H](N)COc2ccc(-c3n[nH]c(=O)o3)cc21.Cl,,ClCCl,,C1COCCO1,,val
US20140135311A1,COC(=O)c1cnc(Cl)c(Cl)c1.CSc1nc2c(c(Nc3ccc(C(F)(F)F)cc3)n1)CCNCC2>>COC(=O)c1cnc(N2CCc3nc(SC)nc(Nc4ccc(C(F)(F)F)cc4)c3CC2)c(Cl)c1,,CN(C)C=O,O,CCN(CC)CC,,val
US20020002183A1,CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(C(=O)O)cc1.Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1>>CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)cc1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US04012524,C=O.CSc1ccc(C(=O)CC2CCCC2)c(Cl)c1Cl>>C=C(C(=O)c1ccc(SC)c(Cl)c1Cl)C1CCCC1,,C1COCCO1,,O=S(=O)(O)O,,val
US05464867,CCOc1c(Nc2ccc(C#N)cc2)c(=O)c1=O.C[C@@H](N)C(C)(C)C>>C[C@@H](Nc1c(Nc2ccc(C#N)cc2)c(=O)c1=O)C(C)(C)C,,CCO,,,,val
US05668289,C=CCn1c(C(F)(F)F)ccc(N)c1=O.O=S(=O)(Cl)Cc1ccccc1>>C=CCn1c(C(F)(F)F)ccc(NS(=O)(=O)Cc2ccccc2)c1=O,,c1ccncc1,,,,val
US04115575,CC(C)NCC(O)COc1nccnc1Cl.CO>>COc1nccnc1OCC(O)CNC(C)C.Cl,,CO,,C[O-].[Na+],,val
US20100267634A1,CC(C)(C)OC(=O)N1CCC[C@H]1/C=C/c1ccc(CBr)cc1.O=[N+]([O-])c1ccc(CNc2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC[C@H]1/C=C/c1ccc(CN(Cc2ccc([N+](=O)[O-])cc2)c2ccccc2)cc1,,CN(C)C=O,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US04647584,CCCc1cc(N)cc(C)c1O.O=C(Cl)Cl>>CCCc1cc(N=C=O)cc(C)c1O,,CCOC(C)=O,,,,val
US20080274892A1,CC(C)COC(=O)Cl.CC1(C)CN(Cc2ccccc2NS(=O)(=O)C(F)(F)F)C(=O)S1>>CC(C)COC(=O)N(c1ccccc1CN1CC(C)(C)SC1=O)S(=O)(=O)C(F)(F)F,,CC#N,,O=C([O-])O.[Na+],,val
US20020058689A1,c1ccc2c3c([nH]c2c1)CCC3>>c1ccc2c(c1)NC1CCCC21,[Pd],,,Cl,,val
US20050004134A1,CC(C)n1nc(-c2sc(C#N)nc2-c2ccccc2)ccc1=O.CC(N)=S>>CC(C)n1nc(-c2sc(C(N)=S)nc2-c2ccccc2)ccc1=O,,C1COCCO1,CN(C)C=O,Cl,O,val
US20050171087A1,CCOC(=O)C(F)(F)F.N[C@@H]1CCCN2c3cc(Cl)ccc3Nc3ccccc3[C@H]12>>O=C(N[C@@H]1CCCN2c3cc(Cl)ccc3Nc3ccccc3[C@H]12)C(F)(F)F,,CO,,CCN(CC)CC,O,val
US20110230464A1,CCBr.Clc1nc(N2CCOCC2)c2nc[nH]c2n1>>CCn1cnc2c(N3CCOCC3)nc(Cl)nc21,,CN(C)C=O,,[Na+].[OH-],,val
US05708001,CC(C)(C)c1ccc(C(F)(F)F)cc1[N+](=O)[O-]>>CC(C)(C)c1ccc(C(F)(F)F)cc1N,[Pd],CCO,,,,val
US06184225B2,COCCNc1ccc2c(Nc3cc(OC(=O)OC)c(C)cc3F)ncnc2c1.Cl>>COCCNc1ccc2c(Nc3cc(O)c(C)cc3F)ncnc2c1.Cl,,CO,O,[Na+].[OH-],,val
US20070155726A1,C=O.COC(=O)c1ccc(CNCC2CCCCN2C(=O)OC(C)(C)C)cc1>>COC(=O)c1ccc(CN(C)CC2CCCCN2C(=O)OC(C)(C)C)cc1,,CC(Cl)Cl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04835099,CCOC(=O)C(Cc1ccc(OC)cc1)C(=O)C(F)(F)F>>O=C(CCc1ccc(O)cc1)C(F)(F)F,,CC(=O)O,,Br,O,val
US04116741,O=C(O)CCCCC(=O)O.OCCCCO.OCCO>>OCCCCCCO.OCCCCO,,CN(C)C=O,,,,val
US20120202785A1,Nc1ccccc1.O=[N+]([O-])c1ccc(F)c(Br)c1F>>O=[N+]([O-])c1ccc(F)c(Br)c1Nc1ccccc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20090029965A1,O=C(OCc1ccccc1)N1CCC(C2OCCO2)CC1>>C1CC(C2OCCO2)CCN1,[Pd],CO,,,,val
US20130053366A1,Cc1ccc2c(c1)c1c(n2C2=C(Br)CCC2)CCN(C)C1.Cc1csc(B2OC(C)(C)C(C)(C)O2)c1>>Cc1csc(C2=C(n3c4c(c5cc(C)ccc53)CN(C)CC4)CCC2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[K+].[K+],val
US20060194969A1,O=C(CCl)Nc1cc(Br)cc([N+](=O)[O-])c1NC(=O)CCl>>O=[N+]([O-])c1cc(Br)cc2[nH]c(CCl)nc12,,CCO,Cl,O,O=C([O-])O.[Na+],val
US05516774,O=C(Cl)c1ccc([N+](=O)[O-])cc1Cl.c1ccc2c(c1)NCCc1cccn1-2>>O=C(c1ccc([N+](=O)[O-])cc1Cl)N1CCc2cccn2-c2ccccc21,,ClCCl,,CCN(CC)CC,,val
US20090181963A1,CN(C)CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3nnn(C4CCNCC4)c3n2)cc1.O=Cc1ccc[nH]1>>CN(C)CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3nnn(C4CCN(Cc5ccc[nH]5)CC4)c3n2)cc1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20020052322A1,CCOC(=O)C(F)(F)c1cc(F)cc(F)c1>>O=C(O)C(F)(F)c1cc(F)cc(F)c1,,CCO,,[Li+].[OH-],,val
US20150291563A1,CC(=O)c1ccc(-c2cccc(C3CC(C(O)(C(F)(F)F)C(F)(F)F)=NN3c3ccccc3Cl)c2)cc1.C[Mg]Cl>>CC(C)(O)c1ccc(-c2cccc(C3CC(C(O)(C(F)(F)F)C(F)(F)F)=NN3c3ccccc3Cl)c2)cc1,,C1CCOC1,,,,val
US20080090813A1,CCCC(O)=CC(=O)c1cccc(C(F)(F)F)c1.CI>>CCCC(=O)C(C)C(=O)c1cccc(C(F)(F)F)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100168185A1,BrBr.O=C(Cc1ccncc1)c1ccc(Cl)s1>>O=C(c1ccc(Cl)s1)C(Br)c1ccncc1,,CC(=O)O,,,,val
US05556909,COC(=O)C(CCC(C)(C)Cl)N(C)S(N)(=O)=O>>CN1C(CCC(C)(C)Cl)C(=O)NS1(=O)=O,,CO,,C[O-].[Na+],,val
US04159981,CC(C)(C)OC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O.CO>>COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)OC(C)(C)C,[Pd],C1COCCO1,,Cl,[H][H],val
US20060247439A1,CC(=O)n1cc(C=O)c2ccccc21.COc1ccc2nc(NC3CCCC(N)C3)cc(C)c2c1>>COc1ccc2nc(NC3CCCC(NCc4cn(C(C)=O)c5ccccc45)C3)cc(C)c2c1,,CC(=O)O,,[BH3-]C#N.[Na+],,val
US20100249075A1,COc1ccc(C2C(=O)c3ccc(OC)cc3C3CCCCC32)cc1>>COc1ccc(C2C(O)c3ccc(OC)cc3C3CCCCC32)cc1,,C1CCOC1,,CCO,[BH4-].[Na+],val
US20040087588A1,CC(C)(C)OC(=O)Nc1cccc(C(=N)NO)c1.O=C1CCC(=O)O1>>CC(C)(C)OC(=O)Nc1cccc(-c2noc(CCC(=O)O)n2)c1,,CN(C)C=O,,,,val
US20080207703A1,BrBr.COCCOCc1csc(NC(=O)NCc2ccc(Cl)c(Cl)c2)n1>>COCCOCc1nc(NC(=O)NCc2ccc(Cl)c(Cl)c2)sc1Br,,ClCCl,,,,val
US20150148374A1,NC(=O)c1nn(CC(=O)O)c2ccccc12.O=C(Nc1ccn(CC(F)(F)F)n1)[C@@H]1C[C@H]2C[C@H]2N1.O=C(O)C(F)(F)F>>NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2ccn(CC(F)(F)F)n2)c2ccccc12.O=C(O)C(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120190086A1,NC(=O)c1ccc[n+]([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](OP(=O)(O)O)[C@@H]3O)[C@@H](O)[C@H]2O)c1>>NC(=O)C1=CN([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](OP(=O)(O)O)[C@@H]3O)[C@@H](O)[C@H]2O)C=CC1,,CC(C)=O,,CC(C)O,,val
US06239074B1,CCOC(=O)C(Cl)=Cc1cc(-n2c(=S)[nH]c3cscc3c2=O)ccc1Cl.CI>>CCOC(=O)C(Cl)=Cc1cc(-n2c(SC)nc3cscc3c2=O)ccc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05409956,O=C(O)CC1Cc2ccccc2C1.OCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>O=C(NCC1Cc2ccccc2C1)OCc1ccccc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20100125082A1,CCCC[Sn](CCCC)(CCCC)c1cc(OC)ccn1.NC1=NC(c2cncnc2)(c2ccc(F)c(Br)c2)c2cccc(F)c21>>COc1ccnc(-c2cc(C3(c4cncnc4)N=C(N)c4c(F)cccc43)ccc2F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20060211603A1,Cc1cccc2oc(=O)[nH]c12.O=C(CBr)OCc1ccccc1>>Cc1cccc2oc(=O)n(CC(=O)OCc3ccccc3)c12,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20160108035A1,CCOC(=O)C1(Sc2ccnc3ccc(O)cc23)CCC1.N#CCBr>>CCOC(=O)C1(Sc2ccnc3ccc(OCC#N)cc23)CCC1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20040132727A1,COc1cc2ncnc(Oc3ccc(N)c(Cl)c3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCCOc1ccc(Cl)cc1>>COc1cc2ncnc(Oc3ccc(NC(=O)OCCCOc4ccc(Cl)cc4)c(Cl)c3)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US20070124152A1,CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN2C(=O)c3ccccc3C2=O)c1=O.NCCO>>O=C(NCCO)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN2C(=O)c3ccccc3C2=O)c1=O,,CCO,,,,val
US20080188533A1,CC(C)(C)OC(=O)NCCNCc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)NCCN(Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1)C(=O)OCc1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US06677383B1,COc1ccc(C=O)cc1O.N#CCc1cccnc1>>COc1ccc(/C=C(\C#N)c2cccnc2)cc1O,,CO,,[Na+].[OH-],,val
US06218538B1,CCOC(=O)CC(=O)COCCN1CCCCC1.OCCCc1ccncc1>>O=C(COCCN1CCCCC1)CC(=O)OCCCc1ccncc1,,Cc1ccccc1,,CCO,,val
US20060276433A1,Cn1c(-c2ccc([N+](=O)[O-])cc2)noc1=O>>Cn1c(-c2ccc(N)cc2)noc1=O,[Zn],CO,,[Cl-].[NH4+],,val
US20100298336A1,CCc1cn(CC)nc1CBr.Cc1cc(O)nc(S)n1>>CCc1cn(C)nc1CSc1nc(C)cc(O)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150175557A1,CC1(C)C(N)C(C)(C)C1O.[O-][n+]1ccc(C(F)(F)F)c(CNc2ncc(C(F)(F)F)c(Cl)n2)c1>>CC1(C)C(O)C(C)(C)C1Nc1nc(NCc2c[n+]([O-])ccc2C(F)(F)F)ncc1C(F)(F)F,,CCO,,CCN(C(C)C)C(C)C,,val
US20070135385A1,CCOC(=O)C(Br)C(C)C.Cc1cc2c(O)cccc2n1Cc1ccccc1>>CCOC(=O)C(Oc1cccc2c1cc(C)n2Cc1ccccc1)C(C)C,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US05093370,CCOC(=O)CCC=CCCc1ccc(CCC=CCCC(=O)OCC)cc1>>CCOC(=O)CCCCCCc1ccc(CCCCCCC(=O)OCC)cc1,[Pd],CCO,,,,val
US20140094462A1,C=CCCC(=O)N[C@H](CO)c1ccccc1.C=CC[C@H](C)C(=O)O>>C=CCCC(=O)N[C@H](COC(=O)[C@@H](C)CC=C)c1ccccc1,,ClCCl,,,,val
US05273680,CC(C)OB(OC(C)C)OC(C)C.CCCCCCOc1ccc(Br)c(F)c1>>CCCCCCOc1ccc(B(O)O)c(F)c1,,C1CCOC1,,Cl,[Li]CCCC,val
US20130344030A1,C=CC1(C(=O)OCC)COC(C)(C)OC1>>C=CC1(C(=O)O)COC(C)(C)OC1,,C1CCOC1,O,CO,[Li+].[OH-],val
US20050176727A1,C=O.CC(=O)c1cccnc1.c1ccc(N2CCNCC2)nc1>>O=C(CCN1CCN(c2ccccn2)CC1)c1cccnc1,,CC(C)O,,Cl,,val
US20120230951A1,COC(=O)N[C@H]1CCc2ccn3c2C1C(=O)C[C@H](c1ncc(-c2ccc(-c4ccc(C(=O)CNC(=O)OC(C)(C)C)cc4)cc2)[nH]1)C3>>COC(=O)N[C@H]1CCc2ccn3c2C1C(=O)C[C@H](c1ncc(-c2ccc(-c4ccc(C(=O)CN)cc4)cc2)[nH]1)C3,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110105474A1,O=C(O)/C=C/c1cccc(/C=C/C(=O)NOC2CCCCO2)c1.c1ccc(N2CCNCC2)cc1>>O=C(/C=C/c1cccc(/C=C/C(=O)N2CCN(c3ccccc3)CC2)c1)NO,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US20020095044A1,COC(=O)c1cccc([N+](=O)[O-])c1CBr.N>>O=C1NCc2c1cccc2[N+](=O)[O-],,CO,,,,val
US20070032478A1,O=[N+]([O-])c1ccc(F)cc1.OCCCN1CCC(F)C1>>O=[N+]([O-])c1ccc(OCCCN2CCC(F)C2)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20130072467A1,CCO.CN1CC(=N)N(C(=O)c2ccccc2)C1=O.O=CC1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1>>CNC1=NC(=O)N(C)/C1=C\C1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1,,CCO,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US04831151,CCc1n(N=C(C)c2ccc([N+](=O)[O-])cc2)cc[n+]1N.CN(C)c1ccc(C=O)cc1.[Cl-]>>CCc1n(N=Cc2ccc(N(C)C)cc2)cc[n+]1N=C(C)c1ccc([N+](=O)[O-])cc1.[Cl-],,CC(=O)O,,,,val
US20070249664A1,BrCCOCc1ccc(Br)cc1.OC(c1ccccc1)(c1ccccc1)C12CCN(CC1)CC2>>OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccc(Br)cc3)(CC1)CC2.[Br-],,CC#N,ClC(Cl)Cl,,,val
US20110152283A1,CC1CC(=O)NN=C1c1ccc(NCc2ccccc2)c([N+](=O)[O-])c1>>CC1CC(=O)NN=C1c1ccc(N)c(N)c1,[Pd],O,,CO,Cl,val
US20160102088A1,COc1ccc(N)cc1.O=C(c1cccnc1)N1CCc2nc(Cl)ncc2C1>>COc1ccc(Nc2ncc3c(n2)CCN(C(=O)c2cccnc2)C3)cc1,,CC(C)O,,CCOC(C)=O,,val
US20070015759A1,COCCN.Clc1ncc(Br)c(Cl)n1>>COCCNc1nc(Cl)ncc1Br,,CC#N,,CCN(CC)CC,CCOC(C)=O,val
US20020038025A1,CCNCCO.CN(c1ccc(OCCCCBr)cc1)S(=O)(=O)c1ccc(C(F)(F)F)cc1>>CCN(CCO)CCCCOc1ccc(N(C)S(=O)(=O)c2ccc(C(F)(F)F)cc2)cc1,,CC(=O)N(C)C,,,,val
US20080045560A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.N#Cc1ccc(Br)cc1F>>CC(=O)c1ccc(C#N)c(F)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,,,,val
US20040034064A1,COC(=O)c1ccccc1-c1ccc(CBr)cc1.Nc1ncccc1[N+](=O)[O-]>>COC(=O)c1ccccc1-c1ccc(CNc2ncccc2[N+](=O)[O-])cc1,,CN(C)C=O,,[H-].[Na+],,val
US20120208817A1,CCOc1cc(C=O)cc([N+](=O)[O-])c1O.NC(N)=O.O=C(Cc1ccccc1)C1CCOC1>>CCOc1cc(C2NC(=O)NC(C3CCOC3)=C2c2ccccc2)cc([N+](=O)[O-])c1O,,CCO,,Cl,,val
US04851413,BrP(Br)Br.COc1c(C)c(C)c(OC)c(CO)c1C>>COc1c(C)c(C)c(OC)c(CBr)c1C,,C1CCOC1,O,,,val
US20080167307A1,CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCOc2ccc(-c3ccc([N+](=O)[O-])cc3)cc2)cs1>>CC(C)(Sc1nc(CCOc2ccc(-c3ccc([N+](=O)[O-])cc3)cc2)cs1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160137648A1,CC(C)(C)OC(=O)N1CCNCC1.Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1C(C)Cl)C3>>Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1C(C)N1CCN(C(=O)OC(C)(C)C)CC1)C3,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20110130438A1,Cl.O=[N+]([O-])c1cccc(COc2ccc(-c3cc(F)c(F)cc3F)cc2)c1>>Cl.Nc1cccc(COc2ccc(-c3cc(F)c(F)cc3F)cc2)c1,[Pd],CCO,CCOC(C)=O,,,val
US20120197014A1,CCCCCCCCBr.Cc1cccc(-c2ccc3[nH]cc(C=O)c3c2)c1>>CCCCCCCCn1cc(C=O)c2cc(-c3cccc(C)c3)ccc21,,CS(C)=O,,O,[H-].[Na+],val
US20100056518A1,CCOC(=O)C=O.N[C@@H]1CC[C@H](Oc2cc3cc[nH]c(=O)c3cc2Cl)CC1>>CCOC(=O)CN[C@@H]1CC[C@H](Oc2cc3cc[nH]c(=O)c3cc2Cl)CC1,,CO,,[BH3-]C#N.[Na+],,val
US20050203109A1,CCOC(=O)CNc1nc(-c2ccccc2Cl)c2ccc(=O)n(-c3ccccc3Cl)c2n1>>O=C(O)CNc1nc(-c2ccccc2Cl)c2ccc(=O)n(-c3ccccc3Cl)c2n1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20120208817A1,CCOc1cc(C=O)cc(Br)c1O.CSSC>>CCOc1cc(C=O)cc(SC)c1O,,c1ccncc1,,,,val
US20110046127A1,CN(Cc1ccc(Cl)c(Cl)c1)c1ccc2ncc([N+](=O)[O-])n2n1>>CN(Cc1ccc(Cl)c(Cl)c1)c1ccc2ncc(N)n2n1,,CCO,,CCOC(C)=O,,val
US20140249126A1,CCn1nc(CO)c(=O)c2cc(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)cc21>>CCn1nc(C=O)c(=O)c2cc(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)cc21,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20100160430A1,Cc1ccc(S(=O)(=O)OCCC(C)C(F)(F)F)cc1.N#CCS(=O)(=O)CCC(F)(F)F>>CC(CCC(C#N)S(=O)(=O)CCC(F)(F)F)C(F)(F)F,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US05162326,CCCCNC.CCCn1c(=O)cc(Cl)n(Cc2ccc(-c3ccccc3-c3nnnn3C(c3ccccc3)(c3ccccc3)c3ccccc3)cc2)c1=O>>CCCCN(C)c1cc(=O)n(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,CCO,,,,val
US20050277635A1,Cc1cc2c(s1)CC(=O)N(C)S2(=O)=O.O=C=Nc1ccccc1>>Cc1cc2c(s1)C(C(=O)Nc1ccccc1)C(=O)N(C)S2(=O)=O,,C1CCOC1,,[H][H],[H-].[Na+],val
US20140080163A1,Cc1nc2ccccc2c2ccccc12.O=C1CCC(=O)N1Br>>BrCc1nc2ccccc2c2ccccc12,,c1ccccc1,,,,val
US20050234057A1,O=C(NC1(C(=O)NC2CCN(c3ccccc3-c3nnn[nH]3)CC2O)CCCCC1)c1cc2ccccc2o1>>O=C(NC1(C(=O)NC2CCN(c3ccccc3-c3nnn[nH]3)CC2=O)CCCCC1)c1cc2ccccc2o1,,CCOC(C)=O,CS(C)=O,CCN(CC)CC,,val
US20090291079A1,CC(C)(C)[Si](C)(C)OC[C@H]1CC[C@@H](CO[Si](C)(C)C(C)(C)C)N1c1nc(-c2ccc([N+](=O)[O-])cc2)nc(N2C3CCC2COC3)n1>>CC(C)(C)[Si](C)(C)OC[C@H]1CC[C@@H](CO[Si](C)(C)C(C)(C)C)N1c1nc(-c2ccc(N)cc2)nc(N2C3CCC2COC3)n1,[Pd],C1CCOC1,,[H][H],,val
US20030229079A1,CC(=O)c1cc(Br)cc(Cc2ccccc2)c1.OCCO>>CC1(c2cc(Br)cc(Cc3ccccc3)c2)OCCO1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04829074,CC(n1ncnn1)C(O)(c1ccc(OC(F)(F)F)cc1)c1ccc(OC(F)(F)F)cc1.CCN(CC)S(F)(F)F>>CC(n1ncnn1)C(F)(c1ccc(OC(F)(F)F)cc1)c1ccc(OC(F)(F)F)cc1,,ClCCl,,O,[K+].[OH-],val
US20150266834A1,CC1(C)OB(c2ccc(F)c(C3CC3)c2)OC1(C)C.COc1nc(Cl)nc(Cl)n1>>COc1nc(Cl)nc(-c2ccc(F)c(C3CC3)c2)n1,,C1COCCO1,CCOC(C)=O,O,O=C([O-])[O-].[Na+].[Na+],val
US20040167118A1,CCOC(=O)CNC(=O)OC(C)(CC)CC>>CCC(C)(CC)OC(=O)NCC(=O)O,,CO,O,[Li+].[OH-],,val
US20150218173A1,C=C(C)c1cc2c(Nc3ccc4[nH]ncc4c3)ncnc2[nH]1>>CC(C)c1cc2c(Nc3ccc4[nH]ncc4c3)ncnc2[nH]1,[Pd],CN(C)C=O,,CO,,val
US05084572,C=O.CO.NCc1cccc(I)c1.O=C1CCSCC1>>O=C1C2CSCC1CN(Cc1cccc(I)c1)C2,,CO,O,CC(=O)O,[Na+].[OH-],val
US06187802B1,O=C(C(Br)c1ccccc1)C1(c2ccc(Cl)c(Cl)c2)CCC1.S=C1NCCN1>>Br.Clc1ccc(C2(C3=C(c4ccccc4)SC4=NCCN43)CCC2)cc1Cl,,CC(=O)O,,CCO,,val
US20050043336A1,COS(=O)(=O)OC.Cc1cc(C(=O)O)on1>>COC(=O)c1cc(C)no1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160038504A1,Fc1ncc(Br)cc1N1CCOCC1.OC1CCOCC1>>Brc1cnc(OC2CCOCC2)c(N2CCOCC2)c1,,C1COCCO1,,[H-].[Na+],,val
US20150031685A1,CCOC(=O)c1cccc([C@@H](CN2CC[C@H](O[Si](C)(C)C(C)(C)C)C2)N(C)C(=O)OCc2ccccc2)c1.NN>>CN(C(=O)OCc1ccccc1)[C@H](CN1CC[C@H](O[Si](C)(C)C(C)(C)C)C1)c1cccc(C(=O)NN)c1,,CCO,,,,val
US20020187994A1,O=[N+]([O-])O.c1cnc2c(c1)CC1(CN3CCC1CC3)O2>>O=[N+]([O-])c1cnc2c(c1)CC1(CN3CCC1CC3)O2,,O=S(=O)(O)O,,O=C([O-])[O-].[Na+].[Na+],,val
US20130096084A1,CC(C)(C)OC(=O)N1CCC(c2cccc(F)c2)C(N)C1.O=C(O)c1ccc2c(c1)c(Br)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N1CCC(c2cccc(F)c2)C(NC(=O)c2ccc3c(c2)c(Br)nn3C(c2ccccc2)(c2ccccc2)c2ccccc2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060241115A1,CC(C)OB(OC(C)C)OC(C)C.COc1ccc(Br)cn1>>COc1ccc(B(O)O)cn1,,C1CCOC1,,[Li]CCCC,,val
US20090186905A1,O=C(O)COc1ccc(OC(F)(F)F)cc1.O=S(Cl)Cl>>O=C(Cl)COc1ccc(OC(F)(F)F)cc1,CN(C)C=O,,,,,val
US20140179667A1,Cc1c(OC(C)C)ncc2c1C(=O)NCCO2.Cc1cc(C)c(CCl)c(OCc2ccccc2)n1>>Cc1cc(C)c(CN2CCOc3cnc(OC(C)C)c(C)c3C2=O)c(OCc2ccccc2)n1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US03985731,BrBr.O=C1CCCc2ccc(Cl)cc21>>O=C1c2cc(Cl)ccc2CCC1Br,,S=C=S,,,,val
US06180636B2,COc1ccc(C(=O)CBr)cc1.NC(=S)c1cc2c(Nc3cccc(Cl)c3)ncnc2[nH]1>>COc1ccc(-c2csc(-c3cc4c(Nc5cccc(Cl)c5)ncnc4[nH]3)n2)cc1,,CO,,,,val
US20120020884A1,BrBr.O=C1CCCCC1C(=O)N1CCCCC1>>O=C1C(Br)CCCC1C(=O)N1CCCCC1,,CCOCC,,,,val
US20100286145A1,CI.COC(=O)c1cccc(C(=O)Nc2nc(C)cs2)c1>>COC(=O)c1cccc(C(=O)N(C)c2nc(C)cs2)c1,,CN(C)C=O,,[H-].[Na+],,val
US04016281,C=O.COc1cc2c(cc1OC)C(=O)CCC2.Cl.OC1(c2ccccc2)CCNCC1>>COc1cc2c(cc1OC)C(=O)C(CN1CCC(O)(c3ccccc3)CC1)CC2.Cl,,CC(C)O,,CCO,,val
US20160108040A1,CS(=O)(=O)Cl.C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cnnc(OCCO)c4)c4ccccc43)cn12>>C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cnnc(OCCOS(C)(=O)=O)c4)c4ccccc43)cn12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04495349,CN.O=c1cc(-c2cccc(F)c2)oc(=O)[nH]1>>Cn1c(-c2cccc(F)c2)cc(=O)[nH]c1=O,,CO,,C,,val
US04315858,Nc1ccc(-c2ccc(C(=O)O)c(=O)[nH]2)cc1.O=C(Cl)Cc1ccccc1>>O=C(Cc1ccccc1)Nc1ccc(-c2ccc(C(=O)O)c(=O)[nH]2)cc1,,ClCCl,,CCN(CC)CC,C[Si](C)(C)Cl,val
US20140213586A1,N#Cc1cccc(N)c1.O=C(c1c[nH]c2ccccc12)C(Cl)c1ccccc1>>N#Cc1cccc(NC(C(=O)c2c[nH]c3ccccc23)c2ccccc2)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20040073033A1,CCOC(C)=O.O=C(Nc1ccc(C[C@H](NC2=C(Br)C(=O)C23CCCCC3)C(=O)O)cc1)c1c(Cl)cncc1Cl>>O=C(Nc1ccc(C[C@H](NC2=CC(=O)C23CCCCC3)C(=O)OCCO)cc1)c1c(Cl)cncc1Cl,,CCN(CC)CC,,Cl,O,val
US20120142928A1,CCOC(=O)N1CCC(Nc2nc(Cl)ccc2[N+](=O)[O-])CC1.CNC>>CCOC(=O)N1CCC(Nc2nc(N(C)C)ccc2[N+](=O)[O-])CC1,,CO,ClCCl,C1CCOC1,,val
US20080193381A1,CC(C)(C)OC(=O)CCC(NC(=O)NC(CCCCN)C(=O)O)C(=O)OC(C)(C)C.O=S(=O)(Cl)c1ccc(I)cc1>>O=C(O)CCC(NC(=O)NC(CCCCNS(=O)(=O)c1ccc(I)cc1)C(=O)O)C(=O)O,,O,,C1COCCO1,,val
US20060293337A1,N#CCCC[Zn]Br.O=C(CC1CCCCC1)Nc1c(Cl)ccc2nc(Cl)ccc12>>N#CCCCc1ccc2c(NC(=O)CC3CCCCC3)c(Cl)ccc2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,[Cl-],[NH4+],,,val
US20100093777A1,CC(C)(C)OC(=O)N1CCCC2(C1)NC(=O)NC2=O.CC(C)I>>CC(C)N1C(=O)NC2(CCCN(C(=O)OC(C)(C)C)C2)C1=O,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20070078135A1,O=S1(=O)CCN(c2cc(-c3ccncc3Cl)c(Br)cn2)CC1.OB(O)c1ccc(C(F)(F)F)cc1>>O=S1(=O)CCN(c2cc(-c3ccncc3Cl)c(-c3ccc(C(F)(F)F)cc3)cn2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20040266753A1,CCCC(=O)Cl.COc1cc2c(c3c1c(=O)c1c4ccccc4ccc1n3C)[C@@H](O)[C@@H](O)C(C)(C)O2>>CCCC(=O)O[C@@H]1[C@H](O)c2c(cc(OC)c3c(=O)c4c5ccccc5ccc4n(C)c23)OC1(C)C,CN(C)c1ccncc1,c1ccncc1,,,,val
US20030125563A1,C=CCCCCBr.COC1=CC(=O)CC1>>C=CCCCCC1=CC(=O)CC1,,CCOC(C)=O,,C1CCOC1,,val
US20140329825A1,NC(=NO)c1cnc(C(=O)O)c(Cl)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(O)c1ncc(-c2noc(C(F)(F)F)n2)cc1Cl,,C1CCOC1,,,,val
US20100105659A1,BrBr.O=[N+]([O-])c1ncccc1OC1CCCC1>>Nc1ncc(Br)cc1OC1CCCC1,[Zn],CC(=O)O,,,,val
US05041455,CC/C=C\COc1nsnc1-c1cccnc1.CI>>CC/C=C\COc1nsnc1-c1ccc[n+](C)c1.[I-],,CC(C)=O,,,,val
US20120165346A1,CCI.CCc1cc(C2(c3ccnc(Br)c3)N=C(N)c3c(F)cccc32)c[nH]c1=O>>CCc1cc(C2(c3ccnc(Br)c3)N=C(N)c3c(F)cccc32)cn(CC)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20110092501A1,C[Si](C)(C)C#N.Nc1ccc2[nH]cnc2c1.O=C(n1ccnc1)n1ccnc1.O=Cc1ccc(N2CCOCC2)cc1>>O=C1NCC(c2ccc(N3CCOCC3)cc2)N1c1ccc2[nH]cnc2c1,[Pd],,,,,val
US20020188009A1,CCOC(=O)c1ccc(O)cc1.Cc1nc(-c2ccccc2)c(-c2ccccc2)n1CCCBr>>CCOC(=O)c1ccc(OCCCn2c(C)nc(-c3ccccc3)c2-c2ccccc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06278028B1,CCCCCCCCOC(=O)c1ccc(-c2ccc(OC(=O)OC)cc2)cc1.N#Cc1ccccc1O>>CC[C@H](C)COc1ccccc1C#N,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120184735A1,COC(Cl)Cl.COc1ccc(C2(C)CCOCC2)cc1>>COc1ccc(C2(C)CCOCC2)cc1C=O,Cl[Ti](Cl)(Cl)Cl,CCOC(C)=O,ClCCl,Cl,,val
US20160096839A1,C[C@@H]1C=CC[C@@H](NC(=O)OC(C)(C)C)c2cc(ccn2)-c2c(cnn2C(F)F)NC1=O>>C[C@@H]1CCC[C@@H](NC(=O)OC(C)(C)C)c2cc(ccn2)-c2c(cnn2C(F)F)NC1=O,O=[Pt]=O,CCO,,,,val
US20090023720A1,CCNc1nc2c(Oc3ccccc3)nc(C)c(C)c2n1CC(C)C.N>>CCNc1nc2c(N)nc(C)c(C)c2n1CC(C)C,,CO,,,,val
US20090061024A1,C=CP(=O)(OCC)OCC.NCCCN>>CCOP(=O)(OCC)C(C)NCCCN,,CO,,,,val
US20160002177A1,Cn1ccnc1-c1cc(OCOCC[Si](C)(C)C)c2ncn(COCC[Si](C)(C)C)c(=O)c2c1>>Cn1ccnc1-c1cc(O)c2nc[nH]c(=O)c2c1,,O,,O=CO,,val
US20160024091A1,Brc1cnc(Br)cn1.C=CCNCC=C>>C=CCN(CC=C)c1cnc(Br)cn1,,CN(C)C=O,,,,val
US20060135578A1,CCOC(=O)c1cn(Cc2ccccc2)nc1O.Cc1oc(-c2ccco2)nc1COc1ccc(CCl)cc1Br>>CCOC(=O)c1cn(Cc2ccccc2)nc1OCc1ccc(OCc2nc(-c3ccco3)oc2C)c(Br)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090291917A1,CCOc1cc(Cl)ncc1C#N.O=Cc1cc(O)ccc1Br>>CCOc1cc(Oc2ccc(Br)c(C=O)c2)ncc1C#N,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20160222030A1,CC(C)(C)OC(=O)N[C@@H]1COC[C@H]1N.Fc1ccc2nc(Cl)sc2c1>>CC(C)(C)OC(=O)N[C@@H]1COC[C@H]1Nc1nc2ccc(F)cc2s1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20070293548A1,BrC(Br)(Br)Br.CC(O)c1cc(F)cc(C(F)(F)F)c1>>Fc1cc(CCBr)cc(C(F)(F)F)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])O.[Na+],val
US20090306059A1,CCOC(=O)/C=C1\CN(C(c2ccccc2)(c2ccccc2)c2ccccc2)CCC1O.CS(=O)(=O)Cl>>CCOC(=O)/C=C1\CN(C(c2ccccc2)(c2ccccc2)c2ccccc2)CCC1OS(C)(=O)=O,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US05019597,CC(C)(C)c1cc(S)cc(C(C)(C)C)c1O.Cl.O=C(CCl)NC1CN2CCC1CC2>>CC(C)(C)c1cc(SCC(=O)NC2CN3CCC2CC3)cc(C(C)(C)C)c1O.Cl,,CC#N,,CCN(CC)CC,,val
US20060052403A1,CCCCOc1nc(N)c2nc(OC)n(Cc3ccc(C(=O)O)cc3)c2n1.ClCc1cccnc1>>CCCCOc1nc(N)c2nc(O)n(Cc3ccc(C(=O)OCc4cccnc4)cc3)c2n1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20070037828A1,CC1CCNCC1.O=Cc1cnn2c(Cl)c(-c3ncncc3Cl)c(Cl)nc12>>CC1CCN(c2c(-c3ncncc3Cl)c(Cl)nc3c(C=O)cnn23)CC1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20140142083A1,COC(=O)c1cc(Cl)cc(N)c1C.O=C1CCOCC1>>COC(=O)c1cc(Cl)cc(NC2CCOCC2)c1C,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20120220586A1,Brc1ncnc2nc[nH]c12.NCc1cc2cccc(F)c2nc1-c1ccccc1>>Fc1cccc2cc(CNc3ncnc4[nH]cnc34)c(-c3ccccc3)nc12,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20140107097A1,CON(C)C(=O)c1ccc(C(F)(F)F)nc1.Clc1cccc([Mg]Br)c1>>O=C(c1ccc(C(F)(F)F)nc1)c1cccc(Cl)c1,,C1CCOC1,,,,val
US20080125436A1,CCOC(=O)c1ccn(COCC[Si](C)(C)C)c(=O)c1.NN>>C[Si](C)(C)CCOCn1ccc(C(=O)NN)cc1=O,,CCO,,O,,val
US20120316188A1,COc1ccc(Cn2cc(C(N)=S)c(C(F)(F)F)n2)cc1.O=C(CCl)Nc1ccccn1>>COc1ccc(Cn2cc(-c3nc(Nc4ccccn4)cs3)c(C(F)(F)F)n2)cc1,,ClCCl,,Cl,,val
US20140045814A1,COc1cc(CCc2cnc3[nH]c(-c4ccc(N5CCN(C)CC5)cc4)cc3n2)cc(OC)c1.O=C1CCC(=O)N1Br>>COc1cc(CCc2cnc3[nH]c(-c4ccc(N5CCN(C)CC5)cc4)c(Br)c3n2)cc(OC)c1,,ClCCl,,,,val
US20090042891A1,C#Cc1nc(-c2ccncc2)c(-c2ccco2)nc1N>>c1coc(-c2nc3[nH]ccc3nc2-c2ccncc2)c1,,CN1CCCC1=O,,CC(C)(C)[O-].[K+],,val
US20160000760A1,CC(C)(N)C(F)(F)F.O=S(=O)(Cl)c1ccc(Br)cc1>>CC(C)(NS(=O)(=O)c1ccc(Br)cc1)C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150018341A1,CCC(=C(c1ccc(O)cc1)c1ccc(OCCCl)cc1)c1ccc(O)c(OC)c1.CN>>CCC(=C(c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccc(O)c(OC)c1,,CO,,,,val
US04452813,CC(=O)C1CCC(C(C)C)CC1>>CC(=O)[C@@H]1CC[C@@H](C(C)C)CC1,,CO,,C[O-].[Na+],,val
US04052455,N=C(N)c1ccc([N+](=O)[O-])cc1.O=[N+]([O-])c1ccc(C=CS(=O)(=O)Cl)cc1>>N=C(NS(=O)(=O)C=Cc1ccc([N+](=O)[O-])cc1)c1ccc([N+](=O)[O-])cc1,,CC(C)=O,,CCN(CC)CC,,val
US05001125,Clc1ccc(-n2ccnc2)nn1.Oc1ccc(Br)cc1>>Brc1ccc(Oc2ccc(-n3ccnc3)nn2)cc1,,CC(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20110003800A1,O=[N+]([O-])c1ccccc1NCC(F)(F)F>>Nc1ccccc1NCC(F)(F)F,,C1CCOC1,CO,O=C[O-].[NH4+],,val
US20040254233A1,C#CC(C)(O)CCC(C)C.CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F>>C#CC(C)(CC(C)C)O[Si](C)(C)C(C)(C)C,,CCOC(C)=O,,CCN(CC)CC,CN(C)C=O,val
US20030073847A1,COCCl.Cc1cc(OC(=O)c2ccccc2)cc(Cl)c1O>>COCOc1c(C)cc(OC(=O)c2ccccc2)cc1Cl,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20080139549A1,CN(C)C(=O)CCl.COc1cccc(OC)c1C1CCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1>>COc1cccc(OC)c1C1CCN(C(=O)c2cc3cc(Cl)ccc3n2CC(=O)N(C)C)CC1,,CN(C)C=O,,[H-].[Na+],,val
US06750242B1,BrCC=Cc1ccccc1.Oc1ccc2[nH]ccc2c1>>C(=Cc1ccccc1)COc1ccc2[nH]ccc2c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140148440A1,CCC(=O)Cl.NC1CCc2nc(Br)sc2C1>>CCC(=O)NC1CCc2nc(Br)sc2C1,,ClCCl,,CCN(CC)CC,,val
US20110071149A1,Nc1cccc(-c2cnc3ccccc3n2)c1.O=C(Cl)C(Cl)Cl>>O=C(Nc1cccc(-c2cnc3ccccc3n2)c1)C(Cl)Cl,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20040127426A1,COC(=O)[C@H](Cc1c(F)cccc1F)NC(=O)OCc1ccccc1>>O=C(N[C@@H](Cc1c(F)cccc1F)C(=O)O)OCc1ccccc1,,CO,,[Na+].[OH-],,val
US20050096380A1,CC(=O)Cl.COc1ccc2c(c1)C(C)(C)CCC2>>COc1cc2c(cc1C(C)=O)CCCC2(C)C,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130035329A1,CCCCc1ccc(N)cc1.O=C(O)c1cc(S(=O)(=O)Cl)ccc1Br>>CCCCc1ccc(NS(=O)(=O)c2ccc(Br)c(C(=O)O)c2)cc1,,ClCCl,,c1ccncc1,,val
US20050256078A1,COC(=O)CCC(C)=CCc1c(OC)c(C)c2c(c1OCC[Si](C)(C)C)C(=O)OC2>>COc1c(C)c2c(c(OCC[Si](C)(C)C)c1CC=C(C)CCC(=O)O)C(=O)OC2,,CO,O,Cl,[Na+].[OH-],val
US20110118261A1,CN[C@@H]1CCNC1.O=c1cc(OCc2ccc(Cl)cn2)ccn1-c1ccc(F)nc1>>CN[C@@H]1CCN(c2ccc(-n3ccc(OCc4ccc(Cl)cn4)cc3=O)cn2)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040102481A1,CC(C)(C)[Si](C)(C)Cl.O=[N+]([O-])c1ccc(O)cc1Br>>CC(C)(C)[Si](C)(C)Oc1ccc([N+](=O)[O-])c(Br)c1,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20130261295A1,CCOCOc1c(C)cccc1C=O>>CCOCOc1c(C)cccc1CO,,CO,,[BH4-].[Na+],,val
US04254260,CCOC(=O)Cc1csc(NC(=O)C(F)(F)F)n1>>O=C(O)Cc1csc(NC(=O)C(F)(F)F)n1,,O,,[K+].[OH-],,val
US20030078286A1,Cc1c(OC[C@@H]2CCCN2C(=O)OC(C)(C)C)cccc1[N+](=O)[O-]>>Cc1c(N)cccc1OC[C@@H]1CCCN1C(=O)OC(C)(C)C,[Pd],CCO,,,,val
US06110924,O=C1NC(=O)C(Br)(c2ccccc2)C(=O)N1.OCC=C1CCNCC1>>O=C1NC(=O)C(c2ccccc2)(N2CCC(=CCO)CC2)C(=O)N1,,CCO,,CCN(CC)CC,,val
US20160096830A1,CC(C)(C)OC(=O)NCCCC[C@@H](CO)NC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NCCCC[C@@H](C=O)NC(=O)OCc1ccccc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US09439890B2,C#CC1CC1.CC(C)C(=O)NCc1ccc(Cl)c(-n2nc(-c3ccc(I)c(F)c3)[nH]c2=O)c1>>CC(C)C(=O)NCc1ccc(Cl)c(-n2nc(-c3ccc(C#CC4CC4)c(F)c3)[nH]c2=O)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CS(C)=O,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20070099962A1,CC(C)(C)ON=O.CCOC(=O)CC1=C(C)CCNC1=O>>CCOC(=O)CC1=C(C)CCN(N=O)C1=O,,CCOCC,,c1ccncc1,,val
US20080293687A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.COCCOC.N#Cc1cc(C=O)cnc1Cl>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(-c2ncc(C=O)cc2C#N)cc1.CCCC(C)C,,COCCOC,,O=C([O-])O.[Na+],,val
US20100305096A1,CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C3(OC)CN(C(=O)OC(C)(C)C)C3)n(C)c2n1>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C3(OC)CNC3)n(C)c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05703208,CC(C)(C)OC(=O)N(CCc1ccccc1)[C@H]1CCCN(CC(=O)OCc2ccccc2)C1=O>>CC(C)(C)OC(=O)N(CCc1ccccc1)[C@H]1CCCN(CC(=O)O)C1=O,[Pd],CO,,,,val
US05071841,CCOC(=O)C1SCC(=O)c2cc(OC)c(OC)cc21>>COc1cc2c(cc1OC)C(C(=O)O)SCC2=O,,CO,,O,[K+].[OH-],val
US04341901,N#CSc1ccc(N)c(C(F)(F)F)c1>>CSc1ccc(N)c(C(F)(F)F)c1,,CO,,[C-]#N.[Na+],,val
US20020082274A1,COC(=O)c1cnn(-c2ccc(S(C)(=O)=O)cc2Cl)c1C1CC1>>CS(=O)(=O)c1ccc(-n2ncc(C(=O)O)c2C2CC2)c(Cl)c1,,O,,[Na+].[OH-],,val
US20160152624A1,CCc1nc(Cl)nc2c1ccn2C(=O)OC(C)(C)C.COc1ccc(B(O)O)cc1F>>CCc1nc(-c2ccc(OC)c(F)c2)nc2c1ccn2C(=O)OC(C)(C)C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US20080269209A1,OC1CCCc2cnccc21>>O=C1CCCc2cnccc21,,ClCCl,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US20110005947A1,CC(=O)Nc1cccc(Nc2ncc(C(N)=O)c(NCC3CCCNC3)n2)c1.N#CO[K]>>CC(=O)Nc1cccc(Nc2ncc(C(N)=O)c(NCC3CCCN(C(N)=O)C3)n2)c1,,CC#N,O,,,val
US20160200704A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1ccc(N)nc1C1CC1>>CC(C)(C)OC(=O)NCc1ccc(N)nc1C1CC1,,ClCCl,,,,val
US05998433,COc1cc(CC(=O)N2CCc3oc(CN(C)C)cc3C2)ccc1OCc1ccccc1.Cl>>COc1cc(CC(=O)N2CCc3oc(CN(C)C)cc3C2)ccc1OCc1ccccc1.Cl,,CCOC(C)=O,CO,,,val
US05025031,O=C=NS(=O)(=O)Cl.Oc1cccc(Cl)c1Cl>>NS(=O)(=O)Oc1cccc(Cl)c1Cl,,Cc1ccccc1,,c1ccccc1,,val
US20020156111A1,CC(C)(C)OC(=O)Nc1ccc(I)cc1.CI>>CN(C(=O)OC(C)(C)C)c1ccc(I)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20040077669A1,C#CCOc1cc(Cl)ncn1.CCC#CCO>>C#CCOc1cc(OCC#CCC)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20070179151A1,CCCCON=O.COc1ccc2c(c1C)CCC2=O>>COc1ccc2c(c1C)CC(=NO)C2=O,,CO,,Cl,,val
US20090306150A1,CCC(=O)O.CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N>>CCC(=O)[O-].CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N,,CC(C)O,,,,val
US20140073628A1,CC(C)(C)OC(=O)N1CCOc2ccc(B(O)O)cc2C1.COc1ccc(Br)cc1OC(F)F>>COc1ccc(-c2ccc3c(c2)CN(C(=O)OC(C)(C)C)CCO3)cc1OC(F)F,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US05262415,CC(N=C=Nc1ccc(NS(C)(=O)=O)nc1)C(C)(C)C.N#CN>>CC(NC(=NC#N)Nc1ccc(NS(C)(=O)=O)nc1)C(C)(C)C,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20160272592A1,C1COCCO1.N#Cc1cc(Br)ccc1OCC(F)(F)F>>COCc1ccc(OCC(F)(F)F)c(C#N)c1,,CCOC(C)=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050054683A1,CC(=O)NC[C@H]1CN(c2ccc(C3=CCN(C(=O)COC(C)=O)CC3)c(F)c2)C(=O)O1>>CC(=O)NCC1CN(c2ccc(C3=CCN(C(=O)CO)CC3)c(F)c2)C(=O)O1,,CO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20140243310A1,CC(=O)N[C@@H](C)COc1cc2oc(-c3ccc(O)c(F)c3)nc2cn1.CS(=O)(=O)OCCC1CC1(F)F>>CC(=O)N[C@@H](C)COc1cc2oc(-c3ccc(OCCC4CC4(F)F)c(F)c3)nc2cn1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04864052,CCOC(=O)C1C(C=O)C1(C)C.FC(F)(F)C(Cl)(Cl)Cl>>CCOC(=O)C1C(C(O)C(Cl)(Cl)C(F)(F)F)C1(C)C,[Zn],CN(C)C=O,,[Cl-].[NH4+],,val
US20130059832A1,C1CNC1.Cc1ccc(-c2noc(Cl)n2)cc1[N+](=O)[O-]>>Cc1ccc(-c2noc(N3CCC3)n2)cc1[N+](=O)[O-],,CC#N,,CCN(CC)CC,Cl,val
US20100168123A1,Cc1ccccc1C.Clc1ccnc2cc[nH]c12.O=C(O)NC(Cc1ccc(Cl)cc1)C(=O)N1CCNCC1>>CC(C)(C)OC(=O)NC(Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccnc3cc[nH]c23)CC1,,Cc1ccccc1C,,,,val
US04423076,CC(C)(C)CNC(=O)NCCCl.O=N[O-]>>CC(C)(C)CNC(=O)N(CCCl)N=O,,Cl,O,CCO,,val
US20110172429A1,CC(=O)c1ccccc1.O=C1Nc2ccc(OC(F)(F)F)cc2C1=O>>O=C(O)c1cc(-c2ccccc2)nc2ccc(OC(F)(F)F)cc12,,CCO,,Cl,[K+].[OH-],val
US05876984,COC1NC(=O)c2cc(OCc3ccccc3)c3c(c21)O[C@@]12CC[C@H](O)C(C)(C)[C@@H]1CC[C@H](C)[C@@]2(C)C3>>C[C@H]1CC[C@H]2C(C)(C)[C@@H](O)CC[C@]23Oc2c(c(OCc4ccccc4)cc4c2C(O)NC4=O)C[C@]13C,,C1COCCO1,,Cl,O,val
US05646173,CC=CCC1CCc2cccc(Cl)c2C1=O.CO>>O=CCC1CCc2cccc(Cl)c2C1=O,,ClCCl,,,,val
US20140163031A1,COc1ccccc1-n1nc(C2CC(C)(C)OC(C)(C)C2)cc1-c1ccc(Cl)cc1.O=C1CCC(=O)N1Br>>COc1ccccc1-n1nc(C2CC(C)(C)OC(C)(C)C2)c(Br)c1-c1ccc(Cl)cc1,,ClCCl,,,,val
US20100130492A1,CNc1ncc(-c2nc(N3CCOCC3)c3nc(Cl)n(CC4CCOC4)c3n2)cn1.CS(=O)(=O)N1CCNCC1>>CNc1ncc(-c2nc(N3CCOCC3)c3nc(N4CCN(S(C)(=O)=O)CC4)n(CC4CCOC4)c3n2)cn1,,CS(C)=O,,,,val
US20110190278A1,BrC1CC1.Cc1cc2c(cc1C(=O)N(C(C)C)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1)N(CCCCO)C(=O)C(C)(C)O2>>Cc1cc2c(cc1C(=O)N(C(C)C)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1)N(CCCCOC1CC1)C(=O)C(C)(C)O2,,O,,CN(C)C=O,[H-].[Na+],val
US04954501,CC(=O)OC(C)=O.CC1CC(=O)NN=C1c1ccc(NCCN)c([N+](=O)[O-])c1>>CC(=O)NCCNc1ccc(C2=NNC(=O)CC2C)cc1[N+](=O)[O-],,CC(=O)O,,ClCCl,,val
US20100311750A1,CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1c1nc(N2CCCCC2)ncc1C(=O)OC>>CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1c1nc(N2CCCCC2)ncc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110118262A1,CI.COC(=O)c1cc(Br)c(OCc2ccccc2)cc1O>>COC(=O)c1cc(Br)c(OCc2ccccc2)cc1OC,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20080090861A1,CCc1cnn(-c2cccc(C)n2)c1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCc1cnn(-c2cccc(C)n2)c1OS(=O)(=O)C(F)(F)F,,CCN(CC)CC,ClCCl,,,val
US05705646,CCOC(=O)C(C(C)=O)=C(SC)SC.NNc1c(Cl)cc(Cl)cc1Cl>>CCOC(=O)c1c(SC)nn(-c2c(Cl)cc(Cl)cc2Cl)c1C,,CCO,,O,,val
US04094978,COC(=O)C(N)c1ccc(O)cc1.COCCl>>COCOc1ccc(C(N)C(=O)OC)cc1,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US20100087502A1,N#Cc1cc(O)c2cnn(-c3cc(F)c(OCc4ccccc4)c(F)c3)c2c1>>N#Cc1cc(O)c2cnn(-c3cc(F)c(O)c(F)c3)c2c1,[Pd],CCOC(C)=O,,,,val
US20100267699A1,CC(=O)N1CCN(CCCOc2ccc(C3CCN(c4ccc5nnc(C(F)(F)F)n5n4)CC3)cc2)CC1>>CC(=O)N1CCN(CCCOc2ccc(C3CCN(C4=Nn5c(nnc5C(F)(F)F)CC4)CC3)cc2)CC1,[Pd],CCO,ClCCl,O=C[O-].[NH4+],,val
US20130338134A1,CC(C)N.COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(c3cccc(C(=O)O)c3F)C2=O)c1F>>COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(c3cccc(C(=O)NC(C)C)c3F)C2=O)c1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20160002225A1,CCN=C=O.Cc1cnc(NC(=O)c2ccc(Oc3ccnc4[nH]nc(NC5CCNC5)c34)cc2)s1>>CCNC(=O)N1CC[C@@H](Nc2n[nH]c3nccc(Oc4ccc(C(=O)Nc5ncc(C)s5)cc4)c23)C1,,ClCCl,,O,,val
US20040147035A1,CC(=O)OCOC(=O)c1c(-c2c3ccc(N(C)C)cc3[o+]c3cc(N(C)C)ccc23)ccc([N+](=O)[O-])c1N.[Br-]>>CC(=O)OCOC(=O)c1c(-c2c3ccc(N(C)C)cc3[o+]c3cc(N(C)C)ccc23)ccc(N)c1N.[Br-],[Pd],CCO,ClCCl,,,val
US20030069297A1,Cc1cc(C(=O)N2CC[C@H](N(C)C)C2)c(C=O)[nH]1.O=C1Cc2c(cccc2-c2cccc(Cl)c2)N1>>Cc1cc(C(=O)N2CC[C@H](N(C)C)C2)c(C=C2C(=O)Nc3cccc(-c4cccc(Cl)c4)c32)[nH]1,C1CCNCC1,CCO,,,,val
US20090291917A1,N#Cc1cncc(O)c1.O=C1CCC(=O)N1Cl>>N#Cc1cnc(Cl)c(O)c1,,CC#N,,,,val
US20130289033A1,N#Cc1ccccc1B(O)O.O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(I)cc1>>N#Cc1ccccc1-c1ccc(C(=O)NCCc2c[nH]c3ccc(Cl)cc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20120264735A1,CI.OCc1cnc(-c2cccc(Cl)c2)nc1>>COCc1cnc(-c2cccc(Cl)c2)nc1,,O,,CN(C)C=O,[H-].[Na+],val
US20080221129A1,CC(=O)CC(C)=O.COc1cccc(CBr)c1>>COc1cccc(CC(C(C)=O)C(C)=O)c1,,C1CCOC1,,O,,val
US20100093730A1,Cn1ccc(CN)n1.O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O>>Cn1ccc(CNC(=O)CN2CCC(c3ccccc3)(c3ccccc3)C2=O)n1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US04968829,CCOC(=O)NCCCl.O=[N+]([O-])c1ccc(O)cc1>>CCOC(=O)NCCOc1ccc([N+](=O)[O-])cc1,,CCCCCC,CN(C)C=O,CCOCC,[H-].[Na+],val
US20120015962A1,COC(=O)c1cc2cc(Br)ccc2cc1OC>>COc1cc2ccc(Br)cc2cc1C(=O)O,,CCO,O,[Na+].[OH-],,val
US20150274738A1,CC(C)(C)OC(=O)NCCBr.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)c([N+](=O)[O-])c1)nn2C1CCNCC1>>CC(C)(C)OC(=O)NCCN1CCC(n2nc(-c3ccc(Oc4ccccc4)c([N+](=O)[O-])c3)c3c(N)ncnc32)CC1,,CN(C)C=O,O,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20150141401A1,COC(=O)[C@@H]1CC[C@@H](NOCc2ccccc2)CN1.O=C(Cl)OC(Cl)(Cl)Cl>>COC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OCc1ccccc1,CN(C)c1ccncc1,CCN(CC)CC,,CC#N,,val
US20080242655A1,CCOC(=O)c1c(Nc2ccc(I)cc2F)c2cnccc2n1C>>Cn1c(C(=O)O)c(Nc2ccc(I)cc2F)c2cnccc21,,[Na+],[OH-],,,val
US20010021718A1,Cc1oc([C@H](CCCC2CCCCC2)CC(=O)NOCc2ccccc2)nc1C(=O)NCCN(C)C>>Cc1oc([C@H](CCCC2CCCCC2)CC(=O)NO)nc1C(=O)NCCN(C)C,[Pd],CCO,,O=C[O-].[NH4+],,val
US04665065,CC(=O)CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1.O=CO>>CC(=O)CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC=O)[C@H]2SC1,,O=CO,,CC(=O)OC(C)=O,,val
US04316839,CNCC(=O)O.Cc1cccc2[nH]c(=O)oc(=O)c12>>Cc1cccc2c1C(=O)N(C)CC(=O)N2,,CS(C)=O,,,,val
US20110071150A1,COc1cc(F)c(C(O)Cc2cc(Br)ccc2[N+](=O)[O-])c(Cl)c1>>COc1cc(F)c(C(=O)Cc2cc(Br)ccc2[N+](=O)[O-])c(Cl)c1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US04801705,CC(=O)Oc1cccc(C(=O)N(N)C(=O)OC(C)(C)C)c1OC(C)=O>>CC(C)(C)OC(=O)N(N)C(=O)c1cccc(O)c1O,,CO,N,,,val
US05556863,CCC(=O)c1cnc2c(OCCSC)cccc2c1Cl.Cc1ccccc1N>>CCC(=O)c1cnc2c(OCCSC)cccc2c1Nc1ccccc1C,,CC#N,,,,val
US20030191013A1,C[Si](C)(C)OCCC[c-]1ccc2ccccc21.[Cl-].[Cl-].[Zr+3]C1C=CC=C1>>C[Si](C)(C)OCCCC1C([Zr+2]C2C=CC=C2)=Cc2ccccc21.[Cl-].[Cl-],,CCOCC,,[Cl-].[Li+],,val
US04920131,CCOC(=O)CBr.O=C(Cc1cccc(O)c1)c1cccc(O)c1>>CCOC(=O)COc1cccc(CC(=O)c2cccc(O)c2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120302608A1,Cc1nc(NC(=O)c2cc(CNC(=O)OC(C)(C)C)cnc2C(F)F)[nH]c1-c1ccc(C(F)(F)F)cc1>>Cc1nc(NC(=O)c2cc(CN)cnc2C(F)F)[nH]c1-c1ccc(C(F)(F)F)cc1,,O,,Cl,,val
US20140018393A1,CCOC(=O)c1ccc(CCCN2CCOC(CN(C(=O)C(F)(F)F)[C@@H]3C[C@H]3c3ccccc3)C2)cc1>>O=C(O)c1ccc(CCCN2CCOC(CN[C@@H]3C[C@H]3c3ccccc3)C2)cc1,,CO,,[Na+].[OH-],,val
US20130190330A1,FC(F)(F)c1ccccc1-c1cnc(CBr)s1.O=c1[nH]nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F>>O=c1n(Cc2ncc(-c3ccccc3C(F)(F)F)s2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F,,CC#N,CO,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080146606A1,CC(=O)c1cc2c(-c3ccc(S(=O)(=O)N4CCCC4)cc3)ccnc2[nH]1>>CC(O)c1cc2c(-c3ccc(S(=O)(=O)N4CCCC4)cc3)ccnc2[nH]1,,C1CCOC1,O,[BH4-].[Na+],,val
US20070088025A1,CCN1CCNCC1.O=C(Cl)C(=O)Cl.O=C(O)c1cn2c3c(cccc13)CCC2C1CCCC1>>CCN1CCN(C(=O)c2cn3c4c(cccc24)CCC3C2CCCC2)CC1.Cl,,ClCCl,,,,val
US20100266714A1,CC(C)(C)OC(=O)c1cc(Br)cc(C=O)c1.C[Si](C)(C)C(F)(F)F>>CC(C)(C)OC(=O)c1cc(Br)cc(C(O)C(F)(F)F)c1,,C1CCOC1,COC(C)(C)C,Cl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2cc(F)c(O[C@H]3CCCC[C@@H]3c3ccnnc3)cc2F)c(OC)c1>>O=S(=O)(Nc1ccncn1)c1cc(F)c(O[C@H]2CCCC[C@@H]2c2ccnnc2)cc1F,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US05206372,CC(C)S(=O)(=O)CC#N.CN(C)C=CC=O>>CC(C)S(=O)(=O)C(C#N)=CC=CN(C)C,,Cc1ccccc1,O,C1CCNCC1,CC(=O)O,val
US06235771B1,CCCOCCBr.Oc1ccccc1Br>>CCCOCCOc1ccccc1Br,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20130338066A1,CCOC1=NS(=O)(=O)C(C)(c2cccc(Br)c2)C(C)(C)O1.C[C@H](N)c1ccccc1F>>C[C@H](NC1=NS(=O)(=O)C(C)(c2ccccc2)C(C)(C)O1)c1ccccc1F,,C1CCOC1,ClCCl,,,val
US20100105659A1,CI.N#Cc1ncc(Br)cc1[N+](=O)[O-].Oc1ccc(O)nc1>>Cn1cc(Oc2cc(Br)cnc2C#N)ccc1=O,,CN(C)C=O,O,[H-].[Na+],,val
US20020169191A1,CC(=O)NC[C@H]1CN(c2ccc(C(=O)Oc3c(F)c(F)c(F)c(F)c3F)c(F)c2)C(=O)O1.NN>>CC(=O)NC[C@H]1CN(c2ccc(C(=O)NN)c(F)c2)C(=O)O1,,C1CCOC1,,,,val
US20050288502A1,C[C@@H](Cc1cccc(CN=[N+]=[N-])c1)Nc1nccc(N(C)c2nc(-c3ccccc3)cc3ncnn23)n1>>C[C@@H](Cc1cccc(CN)c1)Nc1nccc(N(C)c2nc(-c3ccccc3)cc3ncnn23)n1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060229336A1,CCOC(=O)C(C)(C)C(=O)N1CCC(CCN2[C@H]3CC[C@@H]2CC(n2c(C)nc4ccccc42)C3)(c2cccc(F)c2)CC1>>Cc1nc2ccccc2n1C1C[C@@H]2CC[C@H](C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)C(C)(C)C(=O)O)CC1,,CCO,,[Na+].[OH-],,val
US04873232,CCOC(=O)Nc1cccc(C)c1C(=O)OCC.O=C1CCC(=O)N1Br>>CCOC(=O)Nc1cccc(CBr)c1C(=O)OCC,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,,,val
US20130045986A1,CN(C)C=O.Fc1cc(-n2cnnn2)ccc1-c1ccc2oc(C3CCNCC3)nc2c1.OC1CCC1>>O=C(OC1CCC1)N1CCC(c2nc3cc(-c4ccc(-n5cnnn5)cc4F)ccc3o2)CC1,,CN(C)C=O,,O=C(O)C(F)(F)F,,val
US20080293951A1,CCCN(CCC)CCCCN(CCOC(C)=O)Cc1ccc(CN=Cc2cccc([N+](=O)[O-])c2)cc1>>CCCN(CCC)CCCCN(CCOC(C)=O)Cc1ccc(CN)cc1,,CCO,,Cl,,val
US20100004280A1,CCC(C)(C)CC(O)CNC(=O)C(C)(Cc1ccc(-c2ccc(F)cn2)cc1)NC(=O)OCc1ccccc1>>CCC(C)(C)CC(=O)CNC(=O)C(C)(Cc1ccc(-c2ccc(F)cn2)cc1)NC(=O)OCc1ccccc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05623049,COC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1.CS(=O)(=O)Cl>>COC(=O)[C@@H]1C[C@@H](OS(C)(=O)=O)CN1C(=O)OCc1ccccc1,,ClCCl,c1ccncc1,,,val
US20050130941A1,CC(C)[C@H](N)C(=O)O.COCCOCCO.O=C(Cl)Cl>>COCCOCCOC(=O)N[C@H](C(=O)O)C(C)C,,Cc1ccccc1,,,,val
US20150065705A1,C=O.FC(F)(F)c1sccc1Br>>OCc1cc(Br)c(C(F)(F)F)s1,,C1CCOC1,CCOC(C)=O,Cl,CC(C)[N-]C(C)C.[Li+],val
US20150011546A1,CCOC(=O)C(F)(F)Cl.COc1nc(C)cc(O)c1C#N>>COc1nc(C)cc(OC(F)F)c1C#N,,CN(C)C=O,,[H-].[Na+],,val
US20040138462A1,CC(C)(C)OC(=O)N(CCc1ccc(S(=O)(=O)c2ccc(OC(F)F)cc2)cc1)C[C@H](O)c1cccc(Cl)c1>>O=S(=O)(c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1)c1ccc(OC(F)F)cc1,,C1COCCO1,CCOC(C)=O,Cl,,val
US20040248913A1,C=C(C)c1ccc(OCOC)c(C(=C)C)n1>>C=C(C)c1ccc(O)c(C(=C)C)n1,,C1CCOC1,,Cl,,val
US04675392,COC(=O)CCSCCO[C@@H]1O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O>>COC(=O)CCSCCO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O,,CO,,[Na],C[O-].[Na+],val
US05650410,CCOC(=O)CC(=O)CCCN(CC)CC.COc1ccc(C(=O)c2cc(OC)c(OC)cc2N)cc1OC>>CCOC(=O)c1c(CCCN(CC)CC)nc2cc(OC)c(OC)cc2c1-c1ccc(OC)c(OC)c1,,CCO,,Cl,,val
US20050256107A1,CC(C)(NC(=O)c1ccc(Br)s1)C(=O)O.CN1CCCCN1c1ccc(N)cc1Cl>>CN1CCCCN1c1ccc(NC(=O)C(C)(C)NC(=O)c2ccc(Br)s2)cc1Cl,,CN1CCCC1=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030119813A1,COc1cc2c(cc1OC)-c1cc(Cl)nc(=O)n1CC2.Cc1cccc(C)c1O>>COc1cc2c(cc1OC)-c1cc(Oc3c(C)cccc3C)nc(=O)n1CC2,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06143764,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.O=C(O)C1CCCCC1>>COc1cc2nccc(Oc3ccc(NC(=O)C4CCCCC4)cc3)c2cc1OC,,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20070066617A1,Cc1cc(C=O)ccc1C(=O)NCC(F)(F)F.NO>>Cc1cc(C=NO)ccc1C(=O)NCC(F)(F)F,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20110166142A1,CC(=O)Oc1ccc(C2=Cc3c(C)cc(OC(C)=O)cc3OC2C)cc1>>Cc1cc(O)cc2c1C=C(c1ccc(O)cc1)C(C)O2,,CO,O,CC(=O)O,[K+].[OH-],val
US04091220,Cl.Nc1c(Br)cc(Br)cc1CN1CCN(CC(=O)N2CCOCC2)CC1.O=C(Cl)c1ccccc1>>Cl.O=C(Nc1c(Br)cc(Br)cc1CN1CCN(CC(=O)N2CCOCC2)CC1)c1ccccc1,,c1ccncc1,,CC(C)OC(C)C,,val
US20100168080A1,COC(=O)c1cc(Cl)ccc1OCCCOS(C)(=O)=O.Fc1ccc(CC2CNCCCO2)cc1>>COC(=O)c1cc(Cl)ccc1OCCCN1CCCOC(Cc2ccc(F)cc2)C1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140057937A1,Cc1c(Cl)c(C2=NCCN2)nn1CC(=O)N1CCCc2c1cnn2-c1ccc(F)cc1>>Cc1c(Cl)c(-c2ncc[nH]2)nn1CC(=O)N1CCCc2c1cnn2-c1ccc(F)cc1,,CS(C)=O,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20080269193A1,N#Cc1c(F)cc(Br)cc1F.N[C@H]1CCC[C@@H]1OCc1ccccc1>>N#Cc1c(F)cc(Br)cc1N[C@H]1CCC[C@@H]1OCc1ccccc1,,CS(C)=O,,CCN(C(C)C)C(C)C,[Cl-].[NH4+],val
US20090130076A1,CC(C)(C)OC(=O)Nc1nc2c(-c3cccc(Cl)c3)cc(CO)cc2o1.CCOP(=O)(Cl)OCC>>CCOP(=O)(OCC)OCc1cc(-c2cccc(Cl)c2)c2nc(NC(=O)OC(C)(C)C)oc2c1,CN(C)c1ccncc1,C1CCOC1,Cl,,,val
US20080176884A1,CI.OC1CC[C@@]2(O)[C@H]3Cc4ccc(OCc5ccccc5)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5>>COC1CC[C@@]2(O)[C@H]3Cc4ccc(OCc5ccccc5)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5,,C1CCOC1,,[H-].[Na+],,val
US05840732,CCCCC=O.O=C1CSC(=O)N1CCCCSc1cccc2nccn12>>CCCCC=C1SC(=O)N(CCCCSc2cccc3nccn23)C1=O,,CCO,,C1CCNCC1,,val
US20030153568A1,CCN(CC)CC.CCNC(=O)Nc1nc2ccc(CN)cc2s1.ClCCl.O=S(=O)(Cl)Cl>>CCNC(=O)Nc1nc2ccc(CNS(=O)(=O)c3ccccc3)cc2s1,,CCN(CC)CC,,,,val
US20110184011A1,N#Cc1c(Cl)c(-c2cccnc2)n2c1C(=O)CCC2>>N#Cc1c(Cl)c(-c2cccnc2)n2c1C(O)CCC2,,CO,,[BH4-].[Na+],,val
US05442065,COc1ccc(N)cc1.O=CC(C=O)[N+](=O)[O-]>>COc1ccc2ncc([N+](=O)[O-])cc2c1,,CC(=O)O,O,Cl,[Na],val
US20090197898A1,CON.O=C(Cc1ccncc1)c1cccc(F)c1>>CON=C(Cc1ccncc1)c1cccc(F)c1,,c1ccncc1,,,,val
US20130059834A1,Cn1nc(-c2cnc3c(n2)c(C(=O)N[C@@H]2CC[C@H](N)CC2)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21>>Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@@H]4CC[C@H](N)CC4)c3n2)c2ccc(Cl)cc21,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US20140343092A1,COC(=O)c1cc2c(s1)CCCC2.II>>COC(=O)c1sc2c(c1I)CCCC2,,C1CCOC1,CCOC(C)=O,CC(C)NC(C)C,[Li]CCCC,val
US20150011562A1,CCOc1cc(N2CCN(c3ccccc3C)CC2)c(N)cc1C(=O)NCCCN1CCCC1=O.O=C(Cl)c1ccco1>>CCOc1cc(N2CCN(c3ccccc3C)CC2)c(NC(=O)c2ccco2)cc1C(=O)NCCCN1CCCC1=O,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US20120309773A1,NC1CC1.O=C(O)c1cc(Nc2nc(N3CCC[C@H]3CO)nc3ccoc23)n[nH]1>>O=C(NC1CC1)c1cc(Nc2nc(N3CCC[C@H]3CO)nc3ccoc23)n[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100168082A1,CC(C)(C)OC(=O)N1CCc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cc(C(F)(F)F)ccc3F)c2)C1>>O=C(Nc1cc(C(F)(F)F)ccc1F)n1ccc2cc(Oc3ncnc4c3CCNC4)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080058349A1,COc1ccc(C2(c3cccc(Br)c3)NC(=S)SC2=S)cc1.NCCCN>>COc1ccc(C2(c3cccc(Br)c3)NC(=S)N3CCCN=C32)cc1,,CCO,,,,val
US20110039874A1,COc1ccc(N=C=O)cc1.NC1CCC(c2ccccc2)CC1>>COc1ccc(NC(=O)NC2CCC(c3ccccc3)CC2)cc1,,ClCCl,,,,val
US20020068758A1,COCc1c(OCc2ccccc2)c(=O)cc(C)n1C.Cl>>COCc1c(O)c(=O)cc(C)n1C.Cl,[Pd],CO,O,,,val
US20060116383A1,CCOC(=O)CC(c1ccccc1)n1cnc2cc(NC(=O)c3cccc([N+](=O)[O-])c3)ccc21>>O=C(O)CC(c1ccccc1)n1cnc2cc(NC(=O)c3cccc([N+](=O)[O-])c3)ccc21,,Cl,,,,val
US20040092737A1,CCC1N(C)CC2CCCC1(C1([O-])SCCS1)C2=O.CCO>>CCOC(=O)C12CCCC(CN(C)C1)C2,[Ni],,,,,val
US20110053911A1,CC(=O)O.O=C(O)c1cccnc1Br>>COC(=O)c1cccnc1Br,,C1CCOC1,CCOCC,,,val
US20140121198A1,C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CCCNC1.O=C(Cl)CCc1ccccc1>>CC(O)c1nc2cnc3ccsc3c2n1[C@H]1CCCN(C(=O)CCc2ccccc2)C1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US05236822,C[n+]1ccccc1Cl.[I-].c1c[nH]cn1>>C[n+]1ccccc1-n1ccnc1.[I-],,CC#N,,CCN(C(C)C)C(C)C,,val
US20160248021A1,CCOC(=O)CN=[N+]=[N-].O=Cc1ccc(Br)s1>>Brc1cccs1.[N-]=[N+]=NCC(=O)O,,CCO,,[H-].[Na+],,val
US20160024110A1,CI.Oc1cc(Br)c(F)cc1Cl>>COc1cc(Br)c(F)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05290780,CCCCc1nc2ccc(C(C)O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCCCc1nc2ccc(C(C)O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,Cl,CC(C)=O,O,,,val
US20160009720A1,CN1CCNC1=O.Fc1ccc(Br)cn1>>CN1CCN(c2ccc(Br)cn2)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20100280083A1,CC(=O)Cl.COc1cc(C(=N)NO)c(I)cc1OCc1ccccc1>>COc1cc(-c2noc(C)n2)c(I)cc1OCc1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US04267180,CC(=O)N1CCCC1C(=O)Nc1ccc(-c2ncc(C(=O)O)c(O)n2)cc1.O=C(n1ccnc1)n1ccnc1>>CC(=O)N1CCCC1C(=O)Nc1ccc(-c2ncc(C(=O)O)c(O)n2)cc1.c1c[n-]cn1,,C1CCOC1,,,,val
US20100249123A1,CC(=O)Cl.CC(C)(CN)c1ccc([N+](=O)[O-])cc1F>>CC(=O)NCC(C)(C)c1ccc([N+](=O)[O-])cc1F,,ClCCl,,CCN(CC)CC,,val
US20040048857A1,CCCCCC(=O)c1ccc(-c2ccc(CCC(COC(C)=O)(COC(C)=O)NC(C)=O)cc2)cc1>>CCCCCCc1ccc(-c2ccc(CCC(COC(C)=O)(COC(C)=O)NC(C)=O)cc2)cc1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US04460770,CCCCC[C@@H]1CC[C@@H](C(=O)O)CC1>>CCCCC[C@@H]1CC[C@@H](CO)CC1,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20090143372A1,CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(Br)cc23)CC1.C[C@H](NCc1ccc(B(O)O)s1)C(C)(C)C>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccc(CN[C@@H](C)C(C)(C)C)s4)cc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US04654362,CC(=O)OC(C)=O.Nc1ccc2c(c1)CCC(COC1CCCCO1)O2>>CC(=O)Nc1ccc2c(c1)CCC(COC1CCCCO1)O2,,c1ccncc1,,,,val
US20090118277A1,CN(C)/C=C(\C#N)c1ccc(N)cc1.Cc1cccc(S(=O)(=O)Cl)c1C>>Cc1cccc(S(=O)(=O)Nc2ccc(/C(C#N)=C/N(C)C)cc2)c1C,,c1ccncc1,,O,,val
US20020091265A1,CN1CCN(c2cc(I)c(NC(=O)C(C)(C)C)cn2)CC1.Cc1ccccc1B(O)O>>Cc1ccccc1-c1cc(N2CCN(C)CC2)ncc1NC(=O)C(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20060264622A1,COC(=O)CCCBr.COc1cc(C=O)ccc1O>>COC(=O)CCCOc1ccc(C=O)cc1OC,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110071197A1,COC(=O)c1cc(Cl)ccc1[N+](=O)[O-].O=[N+]([O-])c1ccc(S)cc1>>COC(=O)c1cc(Sc2ccc([N+](=O)[O-])cc2)ccc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120040949A1,C1CNC1.Cn1nc(Cl)cc(Nc2ccc(OC(C)(C)C=O)cn2)c1=O>>Cn1nc(Cl)cc(Nc2ccc(OC(C)(C)CN3CCC3)cn2)c1=O,,ClCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US20060094767A1,C[C@@]1(Cn2cc([N+](=O)[O-])nc2Cl)CO1.Oc1ccc(N2CCN(c3ccc(OC(F)(F)F)cc3)CC2)cc1>>C[C@]1(COc2ccc(N3CCN(c4ccc(OC(F)(F)F)cc4)CC3)cc2)Cn2cc([N+](=O)[O-])nc2O1,,CN(C)C=O,,[H-].[Na+],,val
US20050049245A1,CNCC(O)c1cccs1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)sc21>>CN(Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2s1)CC(O)c1cccs1,,O,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20060045953A1,Cc1cc(O)cc(C)c1C(=O)NC1CCCCC1C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(OS(=O)(=O)C(F)(F)F)cc(C)c1C(=O)NC1CCCCC1C,,ClCCl,,c1ccncc1,,val
US20110021569A1,CC(C)(C)OC(=O)N1CCCC(O)C1.O=C=Nc1ccc(F)cc1>>CC(C)(C)OC(=O)N1CCCC(OC(=O)Nc2ccc(F)cc2)C1,,Cc1ccccc1,,,,val
US04288592,Nc1cccnc1Cl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=S(=O)(Nc1cccnc1Cl)C(F)(F)F,,ClCCl,,,,val
US20140056849A1,CC(C)C(=O)Cl.CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F>>CCCS(=O)(=O)N(C(=O)C(C)C)c1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20060247178A1,CC(=O)c1ccccc1.NNC(=S)c1cc(F)ccc1F>>CC1(c2ccccc2)NN=C(c2cc(F)ccc2F)S1,,CCO,ClCCl,,,val
US20120115844A1,CN(C)C=O.Cn1cc(-c2ccc(F)cc2)nn1>>Cn1nnc(-c2ccc(F)cc2)c1C=O,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20080108600A1,Nc1ccc(-c2cccnc2)cn1>>Nc1ccc(C2CCCNC2)cn1,O=[Pt]=O,CC(=O)O,,[H][H],,val
US20140088075A1,CC(=O)OC(C)=O.CCn1c(=O)c(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2Cl)cc2cnc(N)cc21>>CCn1c(=O)c(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2Cl)cc2cnc(NC(C)=O)cc21,,CC#N,,,,val
US03956335,C=CCOc1ccccc1OCC1CO1.O=C1NCCCN1C1CCNCC1>>C=CCOc1ccccc1OCC(O)CN1CCC(N2CCCNC2=O)CC1,,CCO,,,,val
US07495007B2,C=C(N=Cc1cc(F)ccc1C)O[Si](C)(C)C.CC(C)(C)OC(=O)OCCOc1ccc(Cl)cc1/C=C1\C(=O)N(C(=O)OC(C)(C)C)c2cc(Cl)ccc21>>Cc1ccc(F)cc1C1NC(=O)CC(c2cc(Cl)ccc2OCCO)C12C(=O)Nc1cc(Cl)ccc12,,CO,,Cc1ccccc1,,val
US20100004246A1,CC(=O)Nc1cccc(-n2nc(Br)c(=O)n(Cc3ccc(Cl)cc3)c2=O)c1.CO>>COc1nn(-c2cccc(NC(C)=O)c2)c(=O)n(Cc2ccc(Cl)cc2)c1=O,,CO,,C[O-].[Na+],,val
US05312823,C#CCN(Cc1ncccn1)C(=O)OCC>>CCOC(=O)N1Cc2cccnc2C1,,Cc1ccccc1C,,,,val
US20100160302A1,CC1(C23CC4CC2CC(CO)(C4)C3)OCCO1.CS(=O)(=O)Cl>>CC1(C23CC4CC2CC(COS(C)(=O)=O)(C4)C3)OCCO1,CN(C)c1ccncc1,C1CCOC1,O,CCN(CC)CC,,val
US20140275083A1,C[C@H](OC(C)(C)C)[C@H](N)CO.Fc1ncc(F)c(F)n1>>C[C@H](OC(C)(C)C)[C@@H](CO)Nc1nc(F)ncc1F,,CC#N,,CCN(C(C)C)C(C)C,,val
US20160108039A1,CC1NCC2(CC2)NC1=O.COc1cc(C(=O)O)cn2nc(NCc3cccc(Cl)c3)nc12>>COc1cc(C(=O)N2CC3(CC3)NC(=O)C2C)cn2nc(NCc3cccc(Cl)c3)nc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150225405A1,Cc1nc(Cl)ccc1Br.O[C@@H]1CCNC1>>Cc1nc(N2CC[C@@H](O)C2)ccc1Br,,CN(C)C=O,,CCN(CC)CC,,val
US20120035155A1,Cn1c(C(=O)NCc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3)cc2ccccc21>>Cn1c(C(=O)NCc2ccc3c(c2)CCNC3)cc2ccccc21,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US05328924,Clc1nsnc1-c1cccnc1.OCCCCCC(F)(F)F>>FC(F)(F)CCCCCOc1nsnc1-c1cccnc1,,C1CCOC1,,[H-].[Na+],,val
US20120053174A1,Cc1cc(N)nn1C(=O)OC(C)(C)C.Cc1cccc2c(Cl)nc(C(F)(F)c3ccc(F)cn3)nc12>>Cc1cc(Nc2nc(C(F)(F)c3ccc(F)cn3)nc3c(C)cccc23)n[nH]1,,CC(=O)N(C)C,,CC(=O)O,,val
US20090233919A1,CC(=O)OCCC=O.CCOC(=O)C=[N+]=[N-]>>CCOC(=O)CC(=O)CCOC(C)=O,,ClCCl,,Cl[Sn]Cl,,val
US20090105253A1,CCNC(=O)c1ccc([N+](=O)[O-])c(OCC)c1>>CCNC(=O)c1ccc(N)c(OCC)c1,[Pd],CCO,,,,val
US20050124654A1,C=Cc1ccc2c(c1)CC[C@@H](N)C2.O=Cc1ccc2c(c1)CC[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)C2>>C=Cc1ccc2c(c1)CC[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)C2,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20100009986A1,Fc1ccc2[nH]cc(CCBr)c2c1.c1cn[nH]c1>>Fc1ccc2[nH]cc(CCn3cccn3)c2c1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20150210687A1,COC(=O)c1c(Cl)cccc1C(F)(F)F>>OCc1c(Cl)cccc1C(F)(F)F,,C1CCOC1,,Cl,[BH4-].[Li+],val
US05852016,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.OCc1nc[nH]n1>>OCc1ncn(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20020183320A1,Cc1ccccc1C=O.Nc1nc[nH]n1.[C-]#[N+]C(C)(C)C>>Cc1ccccc1-c1nc2nc[nH]n2c1NC(C)(C)C,,[O-][Cl+3]([O-])([O-])O,,,,val
US20090170920A1,CC(C)(C)OC(=O)N[C@H](C(=O)O)c1ccc(O)cc1.CC(C)(C)OCCOc1ccc([C@@H](NC(=O)OC(C)(C)C)C(=O)O)cc1.CN(C)C(=O)CCl>>COc1cc(C(=O)N(C)C)ccc1[C@@](N)(C(=O)O)C(=O)OC(C)(C)C,,O,,CN(C)C=O,[H-].[Na+],val
US05523315,COC1(CN(CC(=O)OCc2ccccc2)C(=O)OC(C)(C)C)CCCCC1>>COC1(CN(CC(=O)O)C(=O)OC(C)(C)C)CCCCC1,,C1CCOC1,O,[Li+].[OH-],,val
US20060205774A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(C3(O)CCN(C(=O)OCc4ccccc4)CC3)cc2)CC1>>O=C(OCc1ccccc1)N1CC=C(c2ccc(OC3CCNCC3)cc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070219186A1,O=C(Cl)C(=O)Cl.O=C(O)c1c[nH]cn1>>Cl.O=C(Cl)c1c[nH]cn1,CN(C)C=O,,,,,val
US20150353499A1,COc1ccc2c(c1)NC(=O)C(N=[N+]=[N-])CC2>>COc1ccc2c(c1)NC(=O)C(N)CC2,[Pd],CCO,,,,val
US20020040014A1,CCOP(=O)(Cl)OCC.c1ccoc1>>CCOP(=O)(OCC)c1ccco1,,CCOCC,,[Li]CCCC,,val
US20120214794A1,ON=C1CCC(c2ccc(Cl)c(Cl)c2)c2ccsc21>>O=C1NCCC(c2ccc(Cl)c(Cl)c2)c2ccsc21,,CCOC(C)=O,,O,,val
US20150087646A1,COC(=O)c1ccc(-n2nc(-c3c(Cl)cccc3Cl)[nH]c2=O)cc1OC.Nc1ccc(F)c(C(F)(F)F)c1>>COc1cc(-n2nc(-c3c(Cl)cccc3Cl)[nH]c2=O)ccc1C(=O)Nc1ccc(F)c(C(F)(F)F)c1,,Cc1ccccc1,,C[Al](C)C,,val
US20050026922A1,CNC(C)(C)C.ClCc1ccc(Cl)nc1>>CN(Cc1ccc(Cl)nc1)C(C)(C)C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080020010A1,O=C1C(C(O)c2ccccc2)=CN=CC1Br>>O=C1C(Br)=CN=CC1Cc1ccccc1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US04473575,CCOC(=O)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CC(=O)c2ccccc21>>CCOC(=O)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CC(=O)C2CCCCC21,O=[Pt],CC(=O)O,,,,val
US20150232463A1,CC1CNCC(C)C1.Cc1nc(C)c(C(=O)C(=O)OC(C)C)c(Cl)c1Br>>Cc1nc(C)c(C(=O)C(=O)OC(C)C)c(N2CC(C)CC(C)C2)c1Br,,CC#N,,CCN(C(C)C)C(C)C,,val
US20100029655A1,CCCO.N#Cc1ccc(F)cc1C(F)(F)F>>CCCOc1ccc(C#N)c(C(F)(F)F)c1,,CCCO,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20040198982A1,CC(C)(C)OC(=O)N1CCN(c2ccc(-c3cccc(N4CCCCC4C(=O)NCC#N)c3)cc2)CC1>>N#CCNC(=O)C1CCCCN1c1cccc(-c2ccc(N3CCNCC3)cc2)c1,,C1COCCO1,,CS(=O)(=O)O,,val
US20140031336A1,CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](NC(=O)OC(C)(C)C)C[C@@H]1C.CN(C)CCN>>CC(=O)N1c2ccc(-c3ccc(C(=O)NCCN(C)C)cc3)cc2[C@H](NC(=O)OC(C)(C)C)C[C@@H]1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080200468A1,COC(=O)c1cscc1NC(=O)CCl.c1ccc2nc(N3CCNCC3)nnc2c1>>COC(=O)c1cscc1NC(=O)CN1CCN(c2nnc3ccccc3n2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20090312338A1,CC1CCCCC1C(=O)O.O=C(Cl)C(=O)Cl>>CC1CCCCC1C(=O)Cl,CN(C)C=O,ClCCl,,,,val
US20120294835A1,Clc1cc(Nc2ccc(N3CCOCC3)cc2)ncn1.NCCO>>OCCNc1cc(Nc2ccc(N3CCOCC3)cc2)ncn1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20110005947A1,CC(=O)Nc1cc([N+](=O)[O-])ccc1OCCN1CCCC1>>CC(=O)Nc1cc(N)ccc1OCCN1CCCC1,[Pd],CCO,,,,val
US20020086942A1,CC(Br)C(=O)Cl.OCCO>>CC(Br)C(=O)OCCO,,C1CCOC1,CCOC(C)=O,Cl,c1ccncc1,val
US20040143115A1,CI.Cc1noc(-c2ccccc2C(=O)N2CCCC[C@H]2CNC(=O)OC(C)(C)C)n1>>Cc1noc(-c2ccccc2C(=O)N2CCCC[C@H]2CN(C)C(=O)OC(C)(C)C)n1,,C1CCOC1,,[H][H],[H-].[Na+],val
US20100137302A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc(Cl)cc1O>>CC(C)(C)OC(=O)Nc1ccc(Cl)cc1O,,C1CCOC1,,,,val
US20140213586A1,CNc1cccc(OC)c1.O=C(c1c[nH]c2ccccc12)C(Cl)c1ccccc1>>COc1cccc(N(C)C(C(=O)c2c[nH]c3ccccc23)c2ccccc2)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080090827A1,CC(C)N.O=C1CCC(c2ccc(OCCCOCc3ccc(OC[C@@H]4CO4)cc3)c(Cl)c2)=NN1>>CC(C)NCC(O)COc1ccc(COCCCOc2ccc(C3=NNC(=O)CC3)cc2Cl)cc1,,CCO,,,,val
US20160122342A1,C=CCCCc1cc(C)nc(OC)c1C#N>>C=CCCCc1cc(C)nc(OC)c1CN,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100048550A1,CCOC(=O)CN(CC(=O)OCC)c1cc(Cl)c(Oc2ccc(OC)c(C(C)CC)c2)c(Cl)c1>>CCC(C)c1cc(Oc2c(Cl)cc(N(CC(=O)O)CC(=O)O)cc2Cl)ccc1O,,ClCCl,,BrB(Br)Br,,val
US20100048623A1,OC(CCC(F)(F)F)CCC(F)(F)F>>O=C(CCC(F)(F)F)CCC(F)(F)F,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20150111894A1,CCC1(CO)COC1.COc1cc(-n2ccc3oc(-c4ccc(Cl)cc4)cc3c2=O)ccc1O>>CCC1(COc2ccc(-n3ccc4oc(-c5ccc(Cl)cc5)cc4c3=O)cc2OC)COC1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06384050B1,COc1ccc(C(=O)N2C[C@H]3CC4C[C@]4(NC(=O)OC(C)(C)C)[C@H]3C2)cc1>>COc1ccc(CN2C[C@H]3CC4C[C@]4(NC(=O)OC(C)(C)C)[C@H]3C2)cc1,,O,,C1CCOC1,[Na+].[OH-],val
US20070093484A1,CC(C)(C)OC(=O)c1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)nc1C(=O)O.NN1CCCCC1>>CC(C)(C)OC(=O)c1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)nc1C(=O)NN1CCCCC1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US05344845,CC1CCC([NH3+])CC1.[Cl-]>>C[C@H]1CC[C@H]([NH3+])CC1.[Cl-],,ClCCl,,,,val
US20150299178A1,O=C(N1CC2CC2C1)C(F)(F)c1nc(Br)cs1.OB(O)c1ccc(Cl)cc1>>O=C(N1CC2CC2C1)C(F)(F)c1nc(-c2ccc(Cl)cc2)cs1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[K+].[K+],val
US05240942,Brc1cccc2c1OCCO2.O=C1CCN(Cc2ccccc2)CC1>>OC1(c2cccc3c2OCCO3)CCN(Cc2ccccc2)CC1,,C1CCOC1,CCCCCC,O,[Li]CCCC,val
US20030033089A1,CNC.[O-][n+]1c(CCl)nc2cc3c(cc2c1-c1ccc2c(c1)OCO2)OCO3>>CN(C)Cc1nc2cc3c(cc2c(-c2ccc4c(c2)OCO4)[n+]1[O-])OCO3,,C1CCOC1,,,,val
US20150329569A1,CCO[Si](CCCNC(=O)NCCCl)(OCC)OCC.S>>CCO[Si](CCCNC(=O)NCCS)(OCC)OCC,,CCO,,C,C[O-].[Na+],val
US20140249139A1,CCOC(=O)c1cncc(-c2ncnc3ccc(-c4ccc(OC)nc4)cc23)c1>>COc1ccc(-c2ccc3ncnc(-c4cncc(C(=O)O)c4)c3c2)cn1,,C1COCCO1,,O,[Li]O,val
US06300342B1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.N#Cc1ccc(CCC(=O)N2CCCc3cc(NS(=O)(=O)c4ccccc4)ccc32)cc1>>N#Cc1ccc(CCC(=S)N2CCCc3cc(NS(=O)(=O)c4ccccc4)ccc32)cc1,,Cc1ccccc1,,,,val
US20150266825A1,CC(C)(C)OC(=O)NC1CNC1.Clc1cncc(Cl)n1>>CC(C)(C)OC(=O)NC1CN(c2cncc(Cl)n2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US04232024,COc1ccc2c(c1)sc1c(C(=O)O)cnc(=O)n12.Nc1nnn[nH]1>>COc1ccc2c(c1)sc1c(C(=O)Nc3nnn[nH]3)cnc(=O)n12,,CN(C)C=O,,O,,val
US07135475B2,CNc1ccc(Cc2nc3c([nH]2)c(=O)n(Cc2ccccc2F)c(=O)n3CC2CC2)cc1.O=C(O)c1cncnc1>>CN(C(=O)c1cncnc1)c1ccc(Cc2nc3c([nH]2)c(=O)n(Cc2ccccc2F)c(=O)n3CC2CC2)cc1,CN(C)c1ccncc1,,,,,val
US20110046132A1,CCOC(=O)c1cnn(-c2nc3cc(S(=O)(=O)Cl)c(Cl)cc3n2COCCOC)c1.Nc1ccccc1>>CCOC(=O)c1cnn(-c2nc3cc(S(=O)(=O)Nc4ccccc4)c(Cl)cc3n2COCCOC)c1,,c1ccncc1,,,,val
US20060193926A1,C1COCCO1.c1cnc2c(c1)ccc1cccnc12.c1csc(-c2cc[nH]c2)n1>>COc1cc(-n2ccc(-c3nccs3)c2)ccc1-c1ccccn1,[Cu]I,,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20110201640A1,CCCc1nc2ccccc2n1Cc1ccc2c(c1)CCc1ccccc1/C2=C\C#N.O>>CCCc1nc2ccccc2n1Cc1ccc2c(c1)CCc1ccccc1/C2=C\C(N)=O,,CCO,,[Na+].[OH-],,val
US20140194415A1,CC(=O)OCCc1ccc(Br)cc1F.O=C1CCC(=O)N1Br>>CC(=O)OCC(Br)c1ccc(Br)cc1F,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20060167052A1,CC(=O)Cl.FC(F)(F)c1cc(CO[C@H]2CCNC[C@H]2c2ccccc2)cc(C(F)(F)F)c1>>CC(=O)N1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1,,C1CCOC1,CCN(CC)CC,Cl,O,val
US20110160243A1,COC(=O)c1ccc(OC(CF)CF)c(Cl)c1>>O=C(O)c1ccc(OC(CF)CF)c(Cl)c1,,C1COCCO1,,Cl,[Li+].[OH-],val
US20070093483A1,NNC(=S)Nc1ccccc1Cl.O=C(O)Cc1ccccc1Cl>>S=c1[nH]nc(Cc2ccccc2Cl)n1-c1ccccc1Cl,,[Na+],[OH-],,,val
US20150087644A1,Cc1nc2ccccc2nc1/C=C/c1cccc(N2CCCC2)n1>>Cc1nc2ccccc2nc1CCc1cccc(N2CCCC2)n1,[Ni],CO,,,,val
US20030069428A1,CC(=O)OC1CC(N2C(=O)c3cccc(N)c3C2=O)C(=O)NC1=O>>Nc1cccc2c1C(=O)N(C1CC(O)C(=O)NC1=O)C2=O,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090203737A1,COC(=O)c1cc(C(C)C)c[nH]1>>CC(C)c1c[nH]c(C(=O)O)c1,,C1COCCO1,O,[Na+].[OH-],,val
US20120083501A1,COc1ccc2c(c1)[C@]1(N=C(N)N(C)C1=O)[C@@]1(C)OCCC[C@@H]1O2>>CN1C(=O)[C@]2(N=C1N)c1cc(O)ccc1O[C@H]1CCCO[C@@]12C,,ClCCl,,BrB(Br)Br,,val
US20070208005A1,Cc1noc(-c2ccc(Cc3ccc4c(c3)CCN(C(=O)OC(C)(C)C)CC4)cc2)n1>>Cc1noc(-c2ccc(Cc3ccc4c(c3)CCNCC4)cc2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080009512A1,COC(=O)C(=Cc1c[n+]([O-])ccc1[N+](=O)[O-])NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NC1Cc2cnccc2NC1=O,[Pd],CCO,,[H][H],,val
US20130303533A1,CSc1nc(N)c(C#N)s1.O=S(=O)(O)O>>CSc1nc(N)c(C(N)=O)s1,,O,,,,val
US05157041,CC(C)(C)OC(=O)[C@@H]1CCCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(N)=O.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CN2CCC[C@H]2C(=O)OC(C)(C)C)cc1,,CCCCCC,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20070249593A1,O=C1CC(c2ccc([N+](=O)[O-])cc2)CC(=O)N1>>Nc1ccc(C2CC(=O)NC(=O)C2)cc1,[Pd],CO,,,,val
US05807882,Clc1nc2ccccc2c2c1Oc1ccccc1O2>>c1ccc2c(c1)Oc1cnc3ccccc3c1O2,[Zn],CC(=O)O,CO,,,val
US20050043336A1,Cl.Fc1cccc2ncnc(Cl)c12.Nc1ccc(C(=O)N2CCCCCC2)c(Cl)c1>>Cl.O=C(c1ccc(Nc2ncnc3cccc(F)c23)cc1Cl)N1CCCCCC1,,CC(C)O,,,,val
US20060252812A1,Brc1cccc2[nH]ccc12.CCCCCBr>>CCCCCn1ccc2c(Br)cccc21,,CN(C)C=O,,[H-].[Na+],,val
US20070167406A1,CC(=CC#N)Nc1cccc(C(F)(F)F)c1.N#CCC(N)=O.N#Cc1ccc(C=O)cc1>>CC1=C(C#N)C(c2ccc(C#N)cc2)C(C(N)=O)=C(N)N1c1cccc(C(F)(F)F)c1,,CCO,,C1CCNCC1,,val
US20140256734A1,Cc1ccnc(C#N)c1.O=C(OO)c1cccc(Cl)c1>>Cc1cc[n+]([O-])c(C#N)c1,,ClCCl,,,,val
US20060264460A1,N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(Cl)c1.O=Cc1cccc(O)c1>>N#Cc1cnc2ccc(NCc3cccc(O)c3)cc2c1Nc1ccc(F)c(Cl)c1,,CCO,,[BH3-]C#N.[Na+],,val
US04590203,CC(=O)OC(C)=O.Cc1ccsc1Cl>>CC(=O)c1cc(C)c(Cl)s1,,O,,O=P(O)(O)O,,val
US20070128764A1,Brc1cccs1.CCCCCCCCCCc1ccc(Br)s1>>CCCCCCCCCCc1ccc(-c2cccs2)s1,,C1CCOC1,,Cl,[Mg],val
US05519029,CN(C)CCN.Cc1ccc(S(=O)(=O)Oc2ccc3c4c(nn3C)-c3cnccc3C(=O)c24)cc1>>CN(C)CCNc1ccc2c3c(nn2C)-c2cnccc2C(=O)c13,,c1ccncc1,,,,val
US20070142452A1,CCN=C=O.CCOC(=O)c1c(CO)c2cc(F)ccc2n1Cc1cccc2ccccc12>>CCNC(=O)OCc1c(C(=O)OCC)n(Cc2cccc3ccccc23)c2ccc(F)cc12,CN(C)c1ccncc1,ClCCl,,,,val
US20110288133A1,CC(C)(C)OC(=O)NC(Cc1ccc(O)cn1)C(=O)NCc1ccc(C(=O)NO)cc1>>NC(Cc1ccc(O)cn1)C(=O)NCc1ccc(C(=O)NO)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110212102A1,Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCCN(C(=O)OC(C)(C)C)C3)c12>>Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCCNC3)c12,,CO,,Cl,,val
US20080103183A1,CCOC(=O)C(C(C)C)N(C(=O)NC1C2CC3CC(C2)CC1C3)C1CC1>>CC(C)c1cn(C2C3CC4CC(C3)CC2C4)c(=O)n1C1CC1,,CCO,,[BH4-].[Na+],,val
US05985900,COC(=O)[C@H](N)C(C)(C)SC.O=S(=O)(Cl)c1ccc(Oc2ccccc2)cc1>>COC(=O)[C@H](NS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(C)(C)SC,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100016279A1,CN(C)S(=O)(=O)Cl.FC(F)(F)c1nnc2ccc(N3CC4CNCC4C3)nn12>>CN(C)S(=O)(=O)N1CC2CN(c3ccc4nnc(C(F)(F)F)n4n3)CC2C1,,Cc1ccccc1,,ClCCl,,val
US20040082784A1,CCC(C)NC1N=CC=C(c2ccc(OC(F)F)cc2Cl)C1[N+](=O)[O-].COC(=O)C(C)=O>>CCC(C)n1c(=O)c(C)nc2c(-c3ccc(OC(F)F)cc3Cl)ccnc21,,Cc1ccccc1,,,,val
US20140148468A1,NCc1ccc(F)cc1.O=C(O)c1scnc1SCCC(F)(F)c1ccc(F)cc1>>O=C(NCc1ccc(F)cc1)c1scnc1SCCC(F)(F)c1ccc(F)cc1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20130109682A1,CC1(C)OC(c2ccncc2[N+](=O)[O-])CC(=O)C1O>>CC1(C)OC(c2ccncc2[N+](=O)[O-])CC(O)C1O,,CCO,CCOC(C)=O,[BH4-].[Na+],,val
US20100022515A1,CS(=O)(=O)Cl.NCCc1ccc(F)c(OCc2ccccc2)c1F>>CS(=O)(=O)NCCc1ccc(F)c(OCc2ccccc2)c1F,,ClCCl,,CCN(CC)CC,O,val
US20090163508A1,CC(C)(C)OC(=O)N1CCN(c2cccc(-c3ccc(F)cc3F)c2)CC1>>Fc1ccc(-c2cccc(N3CCNCC3)c2)c(F)c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100081846A1,CCC(CC)(c1ccc(Br)cc1)P(=O)([O-])[O-].O=Cc1ccc2cc(Br)ccc2c1>>Brc1ccc(/C=C/c2ccc3cc(Br)ccc3c2)cc1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20110245289A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCc1nc2cnc3ccccc3c2n1CCCCNC1CCOCC1>>CCc1nc2cnc3ccccc3c2n1CCCCN(C(=O)OC(C)(C)C)C1CCOCC1,,ClCCl,,CCN(CC)CC,,val
US05962403,O=C1CCCCC1.O=Cc1ccccc1>>O=C1CCCCC1=Cc1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,O,[Na+].[OH-],val
US07557133B2,CC(C)(C)OC(=O)C[C@H](NC(=O)C1(C)CC(c2ccccc2)=NO1)C(=O)COC(=O)c1c(Cl)cccc1Cl>>CC1(C(=O)N[C@@H](CC(=O)O)C(=O)COC(=O)c2c(Cl)cccc2Cl)CC(c2ccccc2)=NO1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060276464A1,CCOC(=O)CNC(=O)N(C)CCNS(=O)(=O)c1cc(S(=O)(=O)c2ccccc2)ccc1C(F)(F)F>>CN(CCNS(=O)(=O)c1cc(S(=O)(=O)c2ccccc2)ccc1C(F)(F)F)C(=O)NCC(=O)O,,CCO,O,[Li+].[OH-],,val
US04551460,CC(C)c1ccc2nc3ccc(C(=O)OCC#N)cn3c(=O)c2c1.CCCC(N)n1ccnc1>>CC(C)c1ccc2nc3ccc(C(=O)NCCCCn4ccnc4)cn3c(=O)c2c1,,O,,CN(C)C=O,,val
US20020040040A1,CN(C(=O)OC(C)(C)C)c1cnc(Cl)cc1-c1ccccc1Cl>>CNc1cnc(Cl)cc1-c1ccccc1Cl,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20040167182A1,Cl.O=C(NOC1CCCCO1)C1(S(=O)(=O)c2ccc(-c3ccc(CCC(F)(F)C(F)(F)F)cn3)cc2)CCOCC1>>Cl.O=C(NO)C1(S(=O)(=O)c2ccc(-c3ccc(CCC(F)(F)C(F)(F)F)cn3)cc2)CCOCC1,,C1COCCO1,,CO,,val
US20090253687A1,CCN(CC)S(F)(F)F.O=C1COc2ccc(-c3cc(CO)nn3-c3ccc(F)cc3)cc2N1>>O=C1COc2ccc(-c3cc(CF)nn3-c3ccc(F)cc3)cc2N1,,ClCCl,,,,val
US06136810,CCN1CN=C(c2cccc(Cl)c2)c2ccc(C)nc21.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CCn1c(=S)nc(-c2cccc(Cl)c2)c2ccc(C)nc21,,ClCCCl,,O=C([O-])O.[Na+],,val
US04377580,CCOC=C(C(=O)OCC)C(=O)OCC.Nc1ncnc2ccc(Cl)cc12>>CCOC(=O)C(=CNc1ncnc2ccc(Cl)cc12)C(=O)OCC,,CN(C)C=O,,O,,val
US20110130393A1,C[Si](C)(C)CCOCn1ncc(C#N)c1Nc1ccc(S(C)(=O)=O)cc1>>CS(=O)(=O)c1ccc(Nc2n[nH]cc2C#N)cc1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20040167155A1,COc1ccccc1C(F)(F)F.O=S(=O)(O)Cl>>COc1ccc(S(=O)(=O)Cl)cc1C(F)(F)F,,ClC(Cl)Cl,,,,val
US04966905,CC1=CC(=O)C(C)(C)O1.O=CC=Cc1ccc(Cl)cc1>>CC1(C)OC(C=CC=Cc2ccc(Cl)cc2)=CC1=O,,CCO,,[Na+].[OH-],,val
US05629428,CCCCCCCCO.CCCCCCCCOc1ccc(-c2ncc(O)cc2Cl)cc1>>CCCCCCCCOc1ccc(-c2ncc(OCCCCCCCC)cc2Cl)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060142277A1,CCOC(=O)[C@H](Cc1ccc(O)cc1)OCC.COS(=O)(=O)CCc1nc(-c2cccs2)oc1C>>CCOC(=O)[C@H](Cc1ccc(OCCc2nc(-c3cccs3)oc2C)cc1)OCC,,Cc1ccccc1,,O,O=C([O-])[O-].[K+].[K+],val
US05837708,CC(C)(C)c1ccc(S(=O)(=O)Cl)s1.COc1ccccc1Oc1c(N)nc(-c2ncccn2)nc1OC>>COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)s2)nc(-c2ncccn2)nc1OC,,C1CCOC1,,[H-].[Na+],,val
US20060142265A1,CC(C)(C)OC(=O)/C=C/c1cnc2c(c1)CN1CCC[C@H]1C(=O)N2.ClCCl>>Cl.O=C(O)/C=C/c1cnc2c(c1)CN1CCC[C@H]1C(=O)N2,,CCOCC,,O=C(O)C(F)(F)F,,val
US04642308,CCCCOc1ccc(C(=O)O)cc1.Nc1ccc2ccc(Cl)nc2n1>>CCCCOc1ccc(C(=O)Nc2ccc3ccc(Cl)nc3n2)cc1,,O,,,,val
US20040209892A1,CN1CCN(Cc2cc(N=C=S)ccc2Cl)CC1.CNC(=O)c1cccc(Oc2ccc(N)c(N)c2)c1>>CNC(=O)c1cccc(Oc2ccc3[nH]c(Nc4ccc(Cl)c(CN5CCN(C)CC5)c4)nc3c2)c1,,CC#N,,ClCCCl,,val
US20090312314A1,CC(=O)O[C@H](C(=O)N(CCc1ccc(C(F)(F)F)cn1)c1ccc(C)c(C)c1)c1ccccc1>>Cc1ccc(N(CCc2ccc(C(F)(F)F)cn2)C(=O)[C@@H](O)c2ccccc2)cc1C,,C1CCOC1,O,[Li+].[OH-],,val
US03978116,COC(=O)c1ccc2cc(C(C)C(=O)O)ccc2c1>>CC(C(=O)O)c1ccc2cc(CO)ccc2c1,,CO,,O,[Na+].[OH-],val
US06211234B1,CCOC(=O)C(=O)C(C=O)c1ccc(OCc2ccccc2)cc1.NN>>CCOC(=O)c1cc(-c2ccc(OCc3ccccc3)cc2)n[nH]1,,CCO,,O,,val
US20120071479A1,CCCN(CCC)C(=O)CCl.Nc1nc(N)c(C(=O)/N=C2\NCC3(CCN(C(=O)CCc4ccc(OCC(=O)O)cc4)CC3)N2)nc1Cl>>CCCN(CCC)C(=O)COC(=O)COc1ccc(CCC(=O)N2CCC3(CC2)CN/C(=N\C(=O)c2nc(Cl)c(N)nc2N)N3)cc1,,CN(C)C=O,O,O=C([O-])O.[Na+],,val
US05686458,CCOC(=O)CNC(C)c1ccccc1C>>Cc1ccccc1C(C)NCCO,,O,,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20130203776A1,CCOC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cccc(OC)n3)nc12>>CCOC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cccc(=O)[nH]3)nc12,,CCOC(C)=O,,Br,CC(=O)O,val
US20150133428A1,CC(=O)c1cccc(F)c1.CCOC(=O)C(=O)OCC>>CCOC(=O)C(=O)CC(=O)c1cccc(F)c1,,CCO,,C,C[O-].[Na+],val
US20040023999A1,CC(C)(C)[Si](C)(C)OC(CCc1ccccn1)C(F)(F)F.CI>>CC(CC(O[Si](C)(C)C(C)(C)C)C(F)(F)F)c1ccccn1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20100204209A1,CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CCCCl>>CCN(CC)CCCN1CCN(C(=O)OC(C)(C)C)CC1,,CO,,CCN(CC)CC,,val
US20150175541A1,CO.Cl.N[C@@H](CO)CC(=O)O>>COC(=O)C[C@@H](N)CO.Cl,,CO,,C1COCCO1,,val
US20030109563A1,COC(=O)C(Cl)C(C)=O.NC(N)=O>>COC(=O)c1oc(N)nc1C,,CO,,,,val
US20100137362A1,N#Cc1nc(Br)cc(Br)c1N.O=C([O-])O.O=S(=O)(O)O>>Nc1c(Br)cc(Br)nc1C(=O)O,,O=S(=O)(O)O,,O,,val
US06300363B1,CCOC(=O)n1c(C(=O)c2ccc(OC)cc2)c(NC(C)=O)c2ccc(Cl)cc21>>COc1ccc(C(=O)c2[nH]c3cc(Cl)ccc3c2NC(C)=O)cc1,,CCCCCC,CCO,,,val
US20060052374A1,[N-]=[N+]=NCc1ccccc1-c1cccnc1>>NCc1ccccc1-c1cccnc1,[Pd],,,,,val
US20050215555A1,BrCCc1ccccc1.Clc1ccc(-c2nc(C3CCNCC3)n3ccccc23)cc1>>Clc1ccc(-c2nc(C3CCN(CCc4ccccc4)CC3)n3ccccc23)cc1,,CC#N,CO,CCN(C(C)C)C(C)C,,val
US03946040,C#CCBr.OCc1ccc2c(c1)OCCO2>>C#CCOCc1ccc2c(c1)OCCO2,,CN(C)C=O,O,[H-].[Na+],,val
US20110059999A1,CN(C)C1(c2ccccc2)CCC(C(O)Cc2ccccc2)CC1.Cl>>CN(C)C1(c2ccccc2)CCC(C(O)Cc2ccccc2)CC1.Cl,,CCOCC,,,,val
US20140114068A1,Cc1cccc(O)c1.O=C1c2ccccc2C(=O)C1(O)O>>Cc1ccc2c(c1)OC1(O)c3ccccc3C(=O)C21O,,CC(=O)O,,,,val
US20140080788A1,NO.O=C1CCCc2c(Br)cccc21>>O/N=C1\CCCc2c(Br)cccc21,,c1ccncc1,,Cl,,val
US20040082611A1,CCON=Cc1ccc(C(=O)OCC)cc1.NCCN>>CCOC(=O)c1ccc(C2=NCCN2)cc1,,CCO,,Cl,,val
US20110183985A1,CC(C)(C)OC(=O)N1CC[C@H](N)C1.CC(C)C(=O)Cl>>CC(C)C(=O)N[C@H]1CCN(C(=O)OC(C)(C)C)C1,,ClCCl,ClCCl,CCN(CC)CC,,val
US20100266714A1,Cc1ccc(-c2cc(C(=O)OC(C)(C)C)cc(C(O)(C(F)(F)F)C(F)(F)F)c2)cc1>>Cc1ccc(-c2cc(C(=O)O)cc(C(O)(C(F)(F)F)C(F)(F)F)c2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050014812A1,CCOC(=O)CCCOc1cc(C)c(N)c([N+](=O)[O-])c1>>CCOC(=O)CCCOc1cc(C)c(N)c(N)c1,[Pd],CCO,,[H][H],,val
US20120122838A1,Clc1cc(OCc2ccccc2)c2nccn2n1>>Cl.Oc1ccnn2ccnc12,[Pd],CO,,,,val
US20040092737A1,CCOC(=O)C1C2CNCC21.ClCc1ccc2c(c1)Nc1nccnc1S2>>CCOC(=O)C1C2CN(Cc3ccc4c(c3)Nc3nccnc3S4)CC21,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])O.[Na+],val
US20140080804A1,CC1(C)OC[C@H](CON)O1.Cn1c(Nc2ccc(I)cc2F)c(C(=O)O)c2occc2c1=O>>Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOC[C@H](O)CO)c2occc2c1=O,,CO,,Cl,,val
US20070072847A1,COc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCN(Cc4ccccc4)CC3)CC2)cc(C)c1O>>COc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCNCC3)CC2)cc(C)c1O,[Pd],CCO,CO,,,val
US20100273806A1,O=C(O)c1cc(Br)cc(OC(F)(F)F)c1.c1nc[nH]n1>>O=C(O)c1cc(OC(F)(F)F)cc(-n2cncn2)c1,[Cu]I,CCOC(C)=O,CN(C)C=O,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20110190294A1,CCOC=O.Cc1noc(C)c1-c1c(/C(N)=N/O)c2ccccc2n1-c1ccc(O)cc1>>Cc1noc(C)c1-c1c(-c2ncon2)c2ccccc2n1-c1ccc(O)cc1,,C1CCOC1,,[H-].[Na+],,val
US06323199B1,COc1ccc(F)cc1C(C)(C)CC(O)(CO)C(F)(F)F>>COc1ccc(F)cc1C(C)(C)CC1(C(F)(F)F)CO1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030134873A1,COC(=O)c1ccc(Br)cc1.COc1ccc(-c2ccccc2)c2nc(N)nn12>>COc1ccc(-c2ccccc2)c2nc(NC(=O)c3ccc(Br)cc3)nn12,,C1COCCO1,Cc1ccccc1,C[Al](C)C,Cl,val
US20100216798A1,CCN1CCCC1CN.Clc1ccc2ncc(-c3ccncc3)n2n1>>CCN1CCCC1CNc1ccc2ncc(-c3ccncc3)n2n1,,COCCOC,,,,val
US20150336960A1,C[C@H]1C[C@@H](c2ccncc2N)C[C@@H](NC(=O)OC(C)(C)C)[C@]1(C)O.S=C(n1ccnc1)n1ccnc1>>C[C@H]1C[C@@H](c2ccncc2N=C=S)C[C@@H](NC(=O)OC(C)(C)C)[C@]1(C)O,,C1CCOC1,,,,val
US20080153850A1,O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(I)ccc1Cl.OB(O)c1ccccc1O>>O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(-c2ccccc2O)ccc1Cl,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,O,O=C([O-])[O-].[K+].[K+],val
US04851409,Cc1ccc2ccc(Cl)cc2n1.O=C1CCC(=O)N1Br>>Clc1ccc2ccc(CBr)nc2c1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20010001101A1,CCOC(=O)c1cnc2c(N)cccc2c1.COC=C1C(=O)OC(C)(C)OC1=O>>CCOC(=O)c1cnc2c(N=C3C(=O)OC(C)(C)OC3=O)cccc2c1,,CCO,,,,val
US20100093733A1,CC(C)OC(=O)[C@@H]1CC[C@@H](c2ccc(N)cc2)CC1.O=C(Cl)c1ccc(Cl)c(Cl)c1>>CC(C)OC(=O)[C@@H]1CC[C@@H](c2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2)CC1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20090233928A1,Cc1ncc(-c2nc(Nc3ccc(C#N)nc3)ncc2F)n1C(C)C.O>>Cc1ncc(-c2nc(Nc3ccc(C(N)=O)nc3)ncc2F)n1C(C)C,,C1CCOC1,O,[Na+].[OH-],,val
US20100173925A1,CC(C)(C)OC(=O)N1CCC(O)(C#N)CC1>>CC(C)(C)OC(=O)N1CCC(O)(CN)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160122342A1,CC=O.CCN(c1cccc2c1CC=CCCc1cc(C)[nH]c(=O)c1CNC2=O)C1CCNCC1>>CCN1CCC(N(CC)c2cccc3c2CC=CCCc2cc(C)[nH]c(=O)c2CNC3=O)CC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20130331419A1,CCC(CC(F)(F)F)(c1ccc(Cl)cc1)n1ncc2c(N)cccc21.CS(=O)(=O)Cl>>CCC(CC(F)(F)F)(c1ccc(Cl)cc1)n1ncc2c(NS(C)(=O)=O)cccc21,,ClCCl,,CN1CCOCC1,,val
US20070191372A1,COc1c2ccccc2nc2ccccc12.NCCCCCCNc1n[n+]([O-])c2ccccc2[n+]1[O-]>>[O-][n+]1nc(NCCCCCCNc2c3ccccc3nc3ccccc23)[n+]([O-])c2ccccc21,,CO,,,,val
US20160096830A1,CC(C)(C)OC(=O)N1CCC[C@H](C(=O)N[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)c2nc3ccccc3s2)C1.Cl>>Cl.O=C(NCCCC[C@H](NC(=O)[C@H]1CCCNC1)C(=O)c1nc2ccccc2s1)OCc1ccccc1,,CCOC(C)=O,,,,val
US05185352,CCCCCCCCCCCCCCCCCCOc1coc(CO)cc1=O.Nc1ccccc1>>CCCCCCCCCCCCCCCCCCOc1cn(-c2ccccc2)c(CO)cc1=O,,O,,Cl,,val
US20060229346A1,CC(=O)Nc1nc(-c2ccc(COC(C)=O)cc2)c(-c2ccc(S(C)(=O)=O)cc2)s1>>CC(=O)Nc1nc(-c2ccc(CO)cc2)c(-c2ccc(S(C)(=O)=O)cc2)s1,,CO,,Cl,O=C([O-])[O-].[K+].[K+],val
US06001855,CCOC(=O)c1sc(N)nc1C.O=C=NCc1ccccc1>>CCOC(=O)c1sc(NC(=O)NCc2ccccc2)nc1C,,CN(C)C=O,,,,val
US20130137700A1,COC(=O)c1nn(-c2ccccc2)cc(OC)c1=O>>COc1cn(-c2ccccc2)nc(C(=O)O)c1=O,,CO,,Cl,[Na+].[OH-],val
US20040127574A1,O=C(OCc1ccccc1)c1ccc(Oc2ccccn2)cc1>>O=C(O)c1ccc(Oc2ccccn2)cc1,[Pd],CCO,,,,val
US20030130305A1,COC(=O)c1ccc2c(c1)C=CC(C)O2>>CC1C=Cc2cc(C(=O)O)ccc2O1,,CO,,[Na+].[OH-],,val
US20120015907A1,C=C1CNCCN(S(C)(=O)=O)c2nc3oc(-c4ccc(F)cc4)c(C(=O)NC)c3cc21.CS(=O)(=O)Cl>>C=C1CN(S(C)(=O)=O)CCN(S(C)(=O)=O)c2nc3oc(-c4ccc(F)cc4)c(C(=O)NC)c3cc21,,ClCCl,,CCN(CC)CC,,val
US20140057909A1,CC(C)N(NC(=O)c1ccccc1)C(=O)/C=C/c1c[nH]c2ccccc12.O=C(Cl)c1ccccc1>>CC(C)N(NC(=O)c1ccccc1)C(=O)/C=C/c1cn(C(=O)c2ccccc2)c2ccccc12,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20160272632A1,N#CCC1(n2nc(Nc3ccc(F)cc3)c3c(OCc4ccccc4)nccc32)CCNCC1.O=C(Cl)C1CC1>>N#CCC1(n2nc(Nc3ccc(F)cc3)c3c(OCc4ccccc4)nccc32)CCN(C(=O)C2CC2)CC1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20020013328A1,CC(C)c1[nH]n(-c2c(Cl)cc(Cl)cc2Cl)c2nc(Cc3ccc(N)cc3)nc(=O)c1-2.O=C(Cl)C(Cl)CCl>>C=C(Cl)C(=O)Nc1ccc(Cc2nc3n(-c4c(Cl)cc(Cl)cc4Cl)[nH]c(C(C)C)c-3c(=O)n2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20040204584A1,COc1ccc(C2COCCO2)c2sc(NC(=O)Oc3ccccc3)nc12.OCC1CCNCC1>>COc1ccc(C2COCCO2)c2sc(NC(=O)N3CCC(CO)CC3)nc12,,ClC(Cl)Cl,,c1ccncc1,,val
US20060247314A1,CC(C)(C)OC(=O)C(C)(C)Br.CCN(C(=O)Oc1ccc(OC(F)(F)F)cc1)C1CCc2cc(S[Si](C(C)C)(C(C)C)C(C)C)ccc2C1>>CCN(C(=O)Oc1ccc(OC(F)(F)F)cc1)C1CCc2cc(SC(C)(C)C(=O)OC(C)(C)C)ccc2C1,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110065708A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.Fc1cc2ncccc2cc1Cn1nnc2ncc(Br)nc21>>C=C(OCC)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US05075440,C=O.CCOC(=O)C1=C(C)NC2=C(C1c1cccc(Cl)c1Cl)S(=O)(=O)CCNC2>>CCOC(=O)C1=C(C)NC2=C(C1c1cccc(Cl)c1Cl)S(=O)(=O)CCN(C)C2,CC(=O)O,CC#N,,O,[BH3-]C#N.[Na+],val
US04608079,CI.O=C1OC(O)c2c(F)cccc21>>COC(=O)c1cccc(F)c1C=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05254595,NC1CCc2ccccc2C1.c1ccc2cc(OCC3CO3)ccc2c1>>OC(CNC1CCc2ccccc2C1)COc1ccc2ccccc2c1,,CCO,,,,val
US04284631,Cc1nc(CON)cs1.O=CNc1nc(C(=O)C(=O)O)cs1>>Cc1nc(CON=C(C(=O)O)c2csc(NC=O)n2)cs1,,CO,,,,val
US04173707,CCC#CCC1(C(=O)OC(C)(C)C)C(=O)C=CC1CC(=O)OC>>CCC#CCC1(C(=O)OC(C)(C)C)C(O)CCC1CC(=O)OC,,CO,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130261130A1,COc1ccc([N+](=O)[O-])c(C(=O)O)c1>>O=C(O)c1cc(O)ccc1[N+](=O)[O-],,O,,[Na+].[OH-],,val
US20120232056A1,COC(=O)C1=CC2N=C(N3CCC[C@@H]3C)C(=O)NC2C=C1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1ccc2nc(OS(=O)(=O)C(F)(F)F)c(N3CCC[C@@H]3C)nc2c1,,ClCCl,,c1ccncc1,,val
US20160024110A1,COc1cccc(O)c1.O=[N+]([O-])c1cc(F)c(Br)cc1F>>COc1cccc(Oc2cc(Br)c(F)cc2[N+](=O)[O-])c1,,C1CCOC1,,[H-].[Na+],,val
US04357411,NNc1ccccn1.O=C1C=C(N2CCOCC2)C(N2CCOCC2)=CC1=O>>Oc1cc(N2CCOCC2)c(N2CCOCC2)cc1N=Nc1ccccn1,,CC(=O)O,,,,val
US20110034507A1,COC(=O)c1cccc(Cn2ccc3cc(OCc4c(COC(C)(C)C)noc4C(C)C)ccc32)c1>>COC(=O)c1cccc(Cn2ccc3cc(OCc4c(CO)noc4C(C)C)ccc32)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100216802A1,CC(C)(C)OC(=O)N[C@@H](CCBr)C(=O)OC1CCCC1.CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCNC4)cc3OC)nc2N1C1CCCC1>>CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(CC[C@H](NC(=O)OC(C)(C)C)C(=O)OC5CCCC5)C4)cc3OC)nc2N1C1CCCC1,,CCOC(C)=O,CN(C)C=O,[I-].[K+],O=C([O-])O.[Na+],val
US20050009843A1,Cn1cc(C(=O)C(=O)N2CCN(c3nc4cc(C(=O)Nc5nc(C(C)(C)C)cs5)ccn4c(=O)c3/C=C/C(=O)OC(C)(C)C)CC2)nc1NC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cn1cc(C(=O)C(=O)N2CCN(c3nc4cc(C(=O)Nc5nc(C(C)(C)C)cs5)ccn4c(=O)c3/C=C/C(=O)O)CC2)nc1N,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100261679A1,CNC(=O)c1cc(Cl)ccn1.Oc1ccc2nc(O)ccc2c1>>CNC(=O)c1cc(Oc2ccc3nc(O)ccc3c2)ccn1,,CN1CCCC1=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090156582A1,N#CCCNC(=O)c1nn(C2CCCCO2)cc1N.O=C(O)C1CCCC1>>N#CCCNC(=O)c1nn(C2CCCCO2)cc1NC(=O)C1CCCC1,,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US04572913,NC1=NN(c2ccc(Cl)cc2)CC1.O=Cc1ccc(Cl)cc1>>Clc1ccc(C=NC2=NN(c3ccc(Cl)cc3)CC2)cc1,CC(=O)O,,,,,val
US06376701B1,CC(O)c1ccccc1.COC(=O)CC(C)=O>>CC(=O)CC(=O)OC(C)c1ccccc1,,Cc1ccccc1,,,,val
US20090209532A1,COc1cc2c(cc1OC)C(=O)OC2>>O=C1OCc2cc(O)c(O)cc21,,ClCCl,,BrB(Br)Br,,val
US20040077675A1,O=C1CCC(=O)N1Cl.ON=Cc1ccc(Br)cc1F>>ON=C(Cl)c1ccc(Br)cc1F,,CN(C)C=O,,,,val
US20130217918A1,CCOc1cc(C(CS(C)(=O)=O)NS(=O)C(C)(C)C)ccc1OC>>CCOc1cc([C@H](N)CS(C)(=O)=O)ccc1OC,,CO,,CCOCC,Cl,val
US04857507,CC(C)CCC(=O)NC(CC(O)C(CC(C)C)NC(=O)OC(C)(C)C)c1ccccc1>>CC(C)CCC(=O)NC(CC(O)C(CC(C)C)NC(=O)OC(C)(C)C)C1CCCCC1,,CC(=O)O,,,,val
US20150175601A1,CC(C)(C)C(=O)Nc1ccc(OC2CCNCC2)cc1F.FCCBr>>CC(C)(C)C(=O)Nc1ccc(OC2CCN(CCF)CC2)cc1F,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US04684640,C=CCS(=O)C1CC(=O)N1C(C(=O)OCc1ccc([N+](=O)[O-])cc1)C(=S)Oc1ccc(OC)cc1>>COc1ccc(OC2=C(C(=O)OCc3ccc([N+](=O)[O-])cc3)N3C(=O)CC3S2)cc1,,C1COCCO1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05003081,CCN.N#CCC#N.O=C(Cl)CCl>>CCN1CC(=O)C(C#N)=C1N,,CN(C)C=O,,CCN(CC)CC,,val
US20090239854A1,COC(=O)c1ccc(NN)cc1.Cc1ccc(CCBr)cn1>>COC(=O)c1ccc(N(N)CCc2ccc(C)nc2)cc1,,CCN(CC)CC,,,,val
US20040122084A1,C=C1C(=O)O[C@H]2C[C@]3(C)O[C@H]3[C@@H]3O[C@@H]3C3=C[C@@H](OC3=O)[C@H]12.CC(C)NC(C)C>>CC(C)N(CC1C(=O)OC2CC3(C)OC3C3OC3C3=CC(OC3=O)C21)C(C)C,,CC(C)=O,,,,val
US04447434,CN1CC=C(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1>>CN1CCC(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1,O=[Pt],CCO,,[H][H],,val
US04621084,CC(Br)C(=O)Br.O=c1[nH]c2ccccc2o1>>CC(Br)C(=O)c1ccc2oc(=O)[nH]c2c1,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20140378483A1,C=c1nc(-c2ccccc2)oc(=O)/c1=C/C(=C\C)C(=O)Cl.Cc1cc2ccccn2c1>>C=c1nc(-c2ccccc2)oc(=O)/c1=C/C(=C\C)C(=O)c1c(C)cc2ccccn12,,C1CCOC1,CCOC(C)=O,,,val
US20090093473A1,CC(=O)O.COC(=O)C1CC(=O)C(N=Nc2ccccc2)=C(O)C1>>COC(=O)C1CC(=O)C(NC(C)=O)=C(O)C1,[Zn],CC(=O)O,,CC(=O)OC(C)=O,,val
US20090203667A1,CC(=O)Cl.CCOC(=O)/C=C/C=C(/C1=CCNCC1)c1ccc(C(F)(F)F)cc1>>CCOC(=O)/C=C/C=C(/C1=CCN(C(C)=O)CC1)c1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20160222033A1,CCOC(=O)CCc1c(C)sc2nc(COc3ccc(F)cc3)cc(=O)n12>>Cc1sc2nc(COc3ccc(F)cc3)cc(=O)n2c1CCCO,,C1CCOC1,CO,[BH4-].[Li+],,val
US20130079321A1,[N-]=[N+]=NC1CCN(c2c([N+](=O)[O-])cnn2C2CC2)CC(O)C1>>[N-]=[N+]=NC1CCN(c2c([N+](=O)[O-])cnn2C2CC2)CC(=O)C1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20060148858A1,CCCc1cn(C(=O)OC(C)(C)C)nc1O.CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO>>CCCc1c[nH]nc1OCCCc1cn(-c2ccc(C(F)(F)F)cn2)nc1OCC,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20100093730A1,COc1ccc(CC2(C)CNCCN2)cc1OC.O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O>>COc1ccc(CC2(C)CN(C(=O)CN3CCC(c4ccccc4)(c4ccccc4)C3=O)CCN2)cc1OC,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060116407A1,Nc1ccc(Cl)cc1.O=C(O)c1csc(COc2ccc(CCCCn3ccnn3)cc2)n1>>O=C(Nc1ccc(Cl)cc1)c1csc(COc2ccc(CCCCn3ccnn3)cc2)n1,,Cl,,,,val
US20110046186A1,COC(=O)C(=O)CC(C)=O.NNc1ncc(Cl)cc1Cl>>COC(=O)c1cc(C)nn1-c1ncc(Cl)cc1Cl,,CC(=O)O,,C1CCOC1,,val
US20110257151A1,CCOC(=O)c1ccc(N)cc1.O=Cc1ccc(F)c(Br)c1>>CCOC(=O)c1ccc(N=Cc2ccc(F)c(Br)c2)cc1,,CCO,,,,val
US20130102576A1,CS(=O)(=O)Nc1ccc2c(c1)C(=O)N(CC(=O)OCc1ccccc1)C2=O.OCCBr>>CS(=O)(=O)N(CCO)c1ccc2c(c1)C(=O)N(CC(=O)OCc1ccccc1)C2=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120264731A1,COC(=O)c1cc([C@H]2CCCN2)c2oc(N3CCOCC3)cc(=O)c2c1.Fc1cc(F)cc(Br)c1>>COC(=O)c1cc([C@H]2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1,CC(=O)O[Pd]OC(C)=O,C1COCCO1,,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US05872138,COc1ccc(C(=O)c2ccc(C#N)cc2)cc1>>COc1ccc(C(O)c2ccc(C#N)cc2)cc1,,CCO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20160122364A1,Brc1cnc2c(Br)snc2c1.NCCc1ccccc1>>Brc1cnc2c(NCCc3ccccc3)snc2c1,,CCO,,,,val
US04348322,CC1(C)OC(c2ccc(-c3ccc(Cl)cc3)cc2)OC1=O>>CC(C)(OCc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)O,[Pd],CCO,,[H][H],,val
US20080153810A1,O=[N+]([O-])c1ccc2[nH]nc(NCc3ncco3)c2c1>>Nc1ccc2[nH]nc(NCc3ncco3)c2c1,[Pd],CO,,,,val
US20140051676A1,O=C(O)c1cccc(Cl)n1.OCC(F)(F)F>>O=C(O)c1cccc(OCC(F)(F)F)n1,,CS(C)=O,O,Cl,[K+].[OH-],val
US20090182023A1,CC(=O)NCC=C1CCc2ccc3nc(C)oc3c21>>CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21,,Cc1ccccc1,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20120058985A1,COC(=O)C1(C(=O)Nc2ccccc2)CC1>>O=C(O)C1(C(=O)Nc2ccccc2)CC1,,C1CCOC1,O,[Li+].[OH-],,val
US04200641,CCc1nc2ccccc2n1CCO.O=S(Cl)Cl>>CCc1nc2ccccc2n1CCCl,,ClC(Cl)Cl,,,,val
US20100160303A1,CC(=O)OC(C)=O.NCc1ccc2c(c1)[nH]c1c(C(N)=O)ccc(Br)c12>>CC(=O)NCc1ccc2c(c1)[nH]c1c(C(N)=O)ccc(Br)c12,,C1CCOC1,,,,val
US04400316,CCOC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)NS(=O)(=O)c1ccc(C)cc1)NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C>>Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)OC(C)(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O)cc1,,CO,,Cl,,val
US04229575,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)OCCl.Cn1nnnc1SCC1=C(C(=O)[O-])N2C(=O)C(NC(=O)Cc3ccc4c(c3)CCO4)C2SC1>>CC(C)C(NC(=O)OC(C)(C)C)C(=O)COC(=O)C1=C(CSc2nnnn2C)CSC2C(NC(=O)Cc3ccc4c(c3)CCO4)C(=O)N12,,CCOC(C)=O,,CN(C)C=O,,val
US20120122842A1,O=C(NCCCCN1C(=O)C2CC3CCOC32c2cc(Cl)ccc21)N1Cc2ccncc2C1>>O=C(NCCCCn1c(=O)c2c(c3cc(Cl)ccc31)C(CCO)C2)N1Cc2ccncc2C1,,CN(C)C=O,O,Cl,[Na+].[OH-],val
US20120123050A1,C[Si](C)(CCCCOc1ccc([N+](=O)[O-])c(F)c1)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)CCCCOc1ccc([N+](=O)[O-])c(F)c1>>C[Si](C)(CCCCOc1ccc(N)c(F)c1)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)CCCCOc1ccc(N)c(F)c1,[Pd],,,[H][H],,val
US20100160424A1,CN(CC(=O)O)C(=O)OC(C)(C)C.CN[C@H](C)[C@H](O)c1ccccc1>>C[C@H]([C@H](O)c1ccccc1)N(C)C(=O)CN(C)C(=O)OC(C)(C)C,,C1CCOC1,,CCN(CC)CC,CCOC(=O)Cl,val
US20050222261A1,CCNCc1ccccc1Cl.COC(=O)c1ccccc1SCCc1ccc(OCC(=O)O)cc1>>CCN(Cc1ccccc1Cl)C(=O)COc1ccc(CCSc2ccccc2C(=O)OC)cc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US05571775,CO.Clc1ccc(Br)c2nc(SCc3ccccc3)nn12>>COc1ccc(Br)c2nc(SCc3ccccc3)nn12,,CC(=O)O,,C[O-].[Na+],,val
US20090197825A1,CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)CO.O=C(O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12>>CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)COC(=O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12,,c1ccncc1,,O=P(Cl)(Cl)Cl,,val
US20120059028A1,C#CCC(C(=O)OC)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCCC3>>C#CCC(C(=O)O)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCCC3,,CO,,[Na+].[OH-],,val
US04622403,O=C(O)C1=CC2=CCCC=C2Sc2c1ccc1c2C(=O)CC1>>O=C(O)C1=CC2=CCCC=C2Sc2c1ccc1c2C(O)CC1,,O,,[Na+].[OH-],,val
US20080269210A1,CON(C)C(=O)c1cccc(SC)c1.Clc1nc(N2CCOCC2)c2sccc2n1>>CSc1cccc(C(=O)c2cc3nc(Cl)nc(N4CCOCC4)c3s2)c1,,C1CCOC1,,[Li]CCCC,,val
US20110281898A1,Nc1cc(F)ccc1O.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]c2cc(F)ccc2o1,,CC#N,ClCCl,,,val
US20160176882A1,CC(C)(N)CO.O=C(O)c1ccc(Br)cn1>>CC(C)(CO)NC(=O)c1ccc(Br)cn1,,ClCCl,,O=S(Cl)Cl,,val
US05620987,CC(C)(C)N1CCc2c([nH]c3ccccc23)C1(C(N)=O)C(=O)OCc1ccccc1>>CC(C)(C)C1(C(N)=O)NCCc2c1[nH]c1ccccc21,,Br,CC(=O)O,,,val
US20080167310A1,COC(=O)CCc1ccc(OCc2ccccc2)c(CNC(=O)OC(C)(C)C)c1>>COC(=O)CCc1ccc(O)c(CNC(=O)OC(C)(C)C)c1,,C1CCOC1,,,,val
US20130184272A1,CCOC(=O)c1sc(S(C)(=O)=O)c2c1CCc1cnn(C)c1-2.Cc1ncccc1O>>CCOC(=O)c1sc(Oc2cccnc2C)c2c1CCc1cnn(C)c1-2,,CN1CCCC1=O,O,CC(C)(C)O[K],,val
US20120115864A1,C=CCNc1ncnc(Cl)c1N.O=C(Cl)c1cccs1>>C=CCNc1ncnc(Cl)c1NC(=O)c1cccs1,,CN1CCCC1=O,O,,,val
US20100113774A1,COc1cc(OC)c(Cl)cc1N.O=C(Br)CBr>>COc1cc(OC)c(NC(=O)CBr)cc1Cl,,ClCCl,O,,,val
US20150322024A1,O=C1c2ccccc2C(=O)N1CCn1ccnc1-c1ccccc1>>NCCn1ccnc1-c1ccccc1,,CCO,,NN,O,val
US20110152321A1,C#CCCCNC(=O)OC(C)(C)C.CI>>C#CCCCN(C)C(=O)OC(C)(C)C,,ClCCl,,C1CCOC1,[H-].[Na+],val
US20140378474A1,Cc1cc(O)nc(C)c1C#N.Cl>>Cc1cc(O)nc(C)c1CN.Cl,[Pd],CO,,,,val
US20160207930A1,CC(C)(C)OC(=O)N1CCN2C(=O)CC[C@H]2C1=O.Cc1cccnc1Br>>Cc1cccnc1C(=O)[C@@H]1CCC(=O)N1CCNC(=O)OC(C)(C)C,,C1CCOC1,,[Li]CCCC,,val
US20090105221A1,CC(C(=O)O)(c1ccccc1)c1ccccc1.CS(=O)(=O)OC1C2CCC1CN(Cc1ccccc1)C2>>CC(C(=O)OCC1C2CCC1CN(Cc1ccccc1)C2)(c1ccccc1)c1ccccc1,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,,val
US20110230486A1,Cc1cc(OCC(C)C)cc(C)c1C(=O)CBr.NC(N)=S>>Cc1cc(OCC(C)C)cc(C)c1-c1csc(N)n1,,CCO,,,,val
US20040220403A1,CI.COc1ccc([N+](=O)[O-])c(OC)c1C(=O)O>>COC(=O)c1c(OC)ccc([N+](=O)[O-])c1OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060094767A1,CC1(Cn2c(=O)n(C3CCNCC3)c3ccccc32)Cn2cc([N+](=O)[O-])nc2O1.O=C(Cl)OCc1ccccc1>>CC1(Cn2c(=O)n(C3CCN(C(=O)OCc4ccccc4)CC3)c3ccccc32)Cn2cc([N+](=O)[O-])nc2O1,,ClCCl,,CCN(CC)CC,,val
US04511573,Cn1c(-c2cccnc2)c(CCCCCC(=O)O)c2cc(Cl)ccc21.O=S(Cl)Cl>>Cn1c(-c2cccnc2)c(CCCCCC(=O)Cl)c2cc(Cl)ccc21,,Cc1ccccc1,,,,val
US20090099244A1,CC(C)C(C)N.CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1CC(=O)c1ccc(C(=O)O)cc1>>CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1CC(=O)c1ccc(C(=O)NC(C)C(C)C)cc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20110052578A1,CC1(C)OB(c2cc(Cl)cc(N)c2F)OC1(C)C.C[Si](C)(C)CCOCn1c(C2CC2)nc(Br)c1-c1ccnc(NCCC#N)n1>>C[Si](C)(C)CCOCn1c(C2CC2)nc(-c2cc(Cl)cc(N)c2F)c1-c1ccnc(NCCC#N)n1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20120245144A1,Cc1nc(-c2cn3c(n2)-c2ccc(OC(C)C4CCCN(C(=O)OC(C)(C)C)CC4)cc2OCC3)n(C(C)C)n1>>Cc1nc(-c2cn3c(n2)-c2ccc(OC(C)C4CCCNCC4)cc2OCC3)n(C(C)C)n1,,C1COCCO1,,Cl,,val
US04060633,CC(=O)CCF.Fc1ccc(-c2ccc(Br)cc2)cc1>>CC(O)(CCF)c1ccc(-c2ccc(F)cc2)cc1,,CCOCC,,[Mg],[Cl-].[NH4+],val
US20150284411A1,CS(=O)(=O)c1nc2nc(Cl)ncc2[nH]1.C[Si](C)(C)CCOCCl>>C[Si](C)(C)CCOCn1c(S(C)(=O)=O)nc2nc(Cl)ncc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20090253689A1,N#Cc1cc(N)ncc1Br.O=CCCl>>N#Cc1cc2nccn2cc1Br,,CCO,,O=C([O-])O.[Na+],,val
US20030187054A1,CCOC(CN1C(=O)C(NC(=O)Nc2ccc(CO[Si](C)(C)C(C)(C)C)cc2)c2ccccc21)OCC.Cc1ccc(NC(=O)CBr)cc1>>CCOC(CN1C(=O)C(CC(=O)Nc2ccc(C)cc2)(NC(=O)Nc2ccc(CO[Si](C)(C)C(C)(C)C)cc2)c2ccccc21)OCC,,CN(C)C=O,,O,CC(C)(C)[O-].[K+],val
US06340679B1,CC(C)(C)OC(=O)[C@@H](N)Cc1ccc(OCCCC(=O)O)cc1.O=S(=O)(Cl)c1ccccc1>>CC(C)(C)OC(=O)[C@H](Cc1ccc(OCCCC(=O)O)cc1)NS(=O)(=O)c1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20140275070A1,CC(C)(C)OC(=O)N1CCC(CN)CC1.FC(F)(F)Cc1cc2c(Cl)ncnc2s1>>CC(C)(C)OC(=O)N1CCC(CNc2ncnc3sc(CC(F)(F)F)cc23)CC1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20040122039A1,CCc1nn2c(-c3ccc(OC)cc3Cl)cccc2c1[N+](=O)[O-]>>CCc1nn2c(-c3ccc(OC)cc3Cl)cccc2c1N,[Zn],CCO,,CC(=O)O,O,val
US20100204272A1,COCCOC1CCC(C)(C(=O)OCC(C)C)CC1>>COCCOC1CCC(C)(C(=O)O)CC1,,C1COCCO1,,[Na+].[OH-],,val
US20160222014A1,CC1(C)CNc2nc(Cl)ncc21.O=S(=O)(Cl)c1cccc2ccccc12>>CC1(C)CN(S(=O)(=O)c2cccc3ccccc23)c2nc(Cl)ncc21,,C1CCOC1,,[H-].[Na+],,val
US20100120761A1,CCN=C=O.Nc1cccc(-c2cnn3cc(-c4ccc(F)cc4)ccc23)c1>>CCNC(=O)Nc1cccc(-c2cnn3cc(-c4ccc(F)cc4)ccc23)c1,,COCCOC,,CCN(CC)CC,,val
US20150000691A1,O=C(Cn1ccnc1)N1CCCc2ccc([N+](=O)[O-])cc21>>O=[N+]([O-])c1ccc2c(c1)N(CCn1ccnc1)CCC2,,C1CCOC1,,Cl,[Na+].[OH-],val
US20140296246A1,CCOc1nc2c(C(=O)c3cnccn3)cc(-c3c(C)noc3C)cc2n1C(=O)OC(C)(C)C.Fc1cc(F)c(Br)c(F)c1>>Cc1noc(C)c1-c1cc(C(O)(c2cnccn2)c2c(F)cc(F)cc2F)c2[nH]c(=O)[nH]c2c1,,CCO,CCOCC,Cl,[Li]CCCC,val
US06384080B1,CC(C)(C)OC(=O)N1CCNCC1.O=C(O)c1cc(S(=O)(=O)Cl)ccc1F>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(F)c(C(=O)O)c2)CC1,,ClCCl,,,,val
US20080227820A1,CC[C@H](C[C@@](O)(C=O)C(F)(F)F)c1cccc(F)c1OC.Nc1cccc2c1cnn2-c1ccc(F)nc1>>CCC(CC(O)(C=Nc1cccc2c1cnn2-c1ccc(F)nc1)C(F)(F)F)c1cccc(F)c1OC,,CC(=O)O,,,,val
US20110218192A1,CNO.N#C/N=C1\CC(c2cccnc2)Oc2ccc(-c3cccc(C#N)c3)cc21>>CN1OC2(CC(c3cccnc3)Oc3ccc(-c4cccc(C#N)c4)cc32)N=C1N,,CO,,Cl,C[O-].[Na+],val
US06458780B1,CCCC[Sn](Cl)(CCCC)CCCC.CNS(=O)(=O)N(CC(=O)c1ncn2ccsc12)S(=O)(=O)NC>>CCCC[Sn](CCCC)(CCCC)c1cn2cnc(C(=O)CN(S(=O)(=O)NC)S(=O)(=O)NC)c2s1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US05798311,COCC#N.Clc1ccc([Mg]Br)cc1.O=S(=O)(O)O>>COCC(=O)c1ccc(Cl)cc1,,CCOCC,O,,,val
US20140350019A1,O=C(Nc1c(F)ccc(O)c1F)c1cc(Br)ccc1F>>Oc1ccc(F)c(NCc2cc(Br)ccc2F)c1F,,C1CCOC1,,,,val
US20040014962A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CC(C)C[C@@H](CO)NC(=O)OCc1ccccc1>>CC(C)C[C@@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)NC(=O)OCc1ccccc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20080300216A1,O=C(O)C(c1ccccc1)(c1ccccc1)c1ccccc1>>OCC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140155375A1,CN1CCc2cc(F)c(-c3cn(C4CN(C(=O)OC(C)(C)C)C4)c4nccc(NS(=O)(=O)c5ccccc5)c34)cc21>>CN1CCc2cc(F)c(-c3cn(C4CNC4)c4nccc(NS(=O)(=O)c5ccccc5)c34)cc21,,ClCCl,,C1COCCO1,Cl,val
US20070088001A1,CCC(N)(C#N)COCc1ccccc1.C[Si](C)(C)CC(NC(=O)N1CCOCC1)C(=O)O>>CCC(C#N)(COCc1ccccc1)NC(=O)C(C[Si](C)(C)C)NC(=O)N1CCOCC1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080234255A1,CCOC(=O)CCNC1CCCC1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>CCOC(=O)CCN(c1nc(Cl)ncc1[N+](=O)[O-])C1CCCC1,,CCOCC,O,O=C([O-])O.[K+],,val
US20130029973A1,Nc1sc2c(c1C(=O)Nc1ccc(Cc3ccncc3)cc1)CCCC2.O=C(O)c1cccc(S(=O)(=O)N2CCOCC2)c1>>O=C(Nc1sc2c(c1C(=O)Nc1ccc(Cc3ccncc3)cc1)CCCC2)c1cccc(S(=O)(=O)N2CCOCC2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06001867,COC(=O)[C@@H](CCN1C(=O)c2ccccc2C1=O)Oc1c(Br)cc(-c2c(Br)ccc3sc4ccccc4c23)cc1Br>>O=C(O)[C@@H](CCN1C(=O)c2ccccc2C1=O)Oc1c(Br)cc(-c2c(Br)ccc3sc4ccccc4c23)cc1Br,,c1ccncc1,,[I-].[Li+],,val
US20140357617A1,COC(=O)C/N=C/c1ccc(OC)cc1>>COC(=O)CNCc1ccc(OC)cc1,,C1CCOC1,CO,[BH4-].[Na+],,val
US20110251205A1,CC[C@@H](NC(=O)OC(C)(C)C)[C@H]1CC[C@@H](C)O1.Cc1ccc(S(=O)(=O)O)cc1>>CC[C@@H](N)[C@H]1CC[C@@H](C)O1.Cc1ccc(S(=O)(=O)O)cc1,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,,val
US20060178377A1,CCOC(=O)c1cn2c(-c3ccc(Cl)cc3Cl)c(C(=O)OC(C)(C)C)c(C)nc2n1>>CCOC(=O)c1cn2c(-c3ccc(Cl)cc3Cl)c(C(=O)O)c(C)nc2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050124622A1,CC(C)(C)OC(=O)NN=Cc1cccc(-c2nnn[nH]2)c1>>CC(C)(C)OC(=O)NNCc1cccc(-c2nnn[nH]2)c1,[Pd],CO,ClCCl,,,val
US20130165446A1,CCCc1nc(CCl)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.CN(C(=O)OC(C)(C)C)c1cc(Sc2ccc(O)cc2)ccc1[N+](=O)[O-]>>CCCc1nc(COc2ccc(Sc3ccc([N+](=O)[O-])c(N(C)C(=O)OC(C)(C)C)c3)cc2)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,CCOC(C)=O,O,CN(C)C=O,[H-].[Na+],val
US20120135990A1,CC(C(=O)NC(C(=O)N1CCC2NCC(Oc3ccc(F)c(F)c3)C21)C(C)(C)C)N(C)C(=O)OCc1ccccc1.CS(=O)(=O)Cl>>CC(C(=O)NC(C(=O)N1CCC2C1C(Oc1ccc(F)c(F)c1)CN2S(C)(=O)=O)C(C)(C)C)N(C)C(=O)OCc1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020099212A1,C=C(Cl)CCl.Sc1ccc(Br)cc1>>Cc1cc2cc(Br)ccc2s1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060252768A1,COc1ccccc1NC1CCN(C(=O)OC(C)(C)C)CC1>>COc1ccccc1NC1CCNCC1,,CCOC(C)=O,CO,Cl,,val
US20150057273A1,CC(C)c1nnc2ccc(O[C@H]3CC[C@H](N)c4ccccc43)cn12.O=C(NC1CC1)Oc1ccc([N+](=O)[O-])cc1>>CC(C)c1nnc2ccc(O[C@H]3CC[C@H](NC(=O)NC4CC4)c4ccccc43)cn12,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US04638000,CCO.O=C(O)C(Br)CCCCCCCN1C(=O)c2ccccc2C1=O>>CCOC(=O)C(Br)CCCCCCCN1C(=O)c2ccccc2C1=O,,O,,O=S(=O)(O)O,,val
US04526960,CCI.CO[C@@H]1C[C@H](NC(C)=O)[C@H](O)[C@H](C)O1>>CCO[C@H]1[C@@H](NC(C)=O)C[C@@H](OC)O[C@H]1C,O=[Ag],CN(C)C=O,,,,val
US20110028492A1,Fc1cccc(CNc2cncc(-c3ccnc(F)c3)n2)c1.N[C@H]1CC[C@H](N)CC1>>N[C@@H]1CC[C@@H](Nc2cc(-c3cncc(NCc4cccc(F)c4)n3)ccn2)CC1,,CS(C)=O,,,,val
US20150210688A1,CC(=O)C(C#N)C1CC1.NN>>Cc1n[nH]c(N)c1C1CC1,,CCO,O,CC(=O)O,O=C([O-])O.[Na+],val
US20100298576A1,CCOC(=O)C=CCC(C(C)=O)C(=O)OCC.COc1ccccc1/C=C/[N+](=O)[O-]>>CCOC(=O)C[C@@H]1C[C@@](C(C)=O)(C(=O)OCC)[C@@H](c2ccccc2OC)[C@@H]1[N+](=O)[O-],,CCOCC,,,,val
US20100029705A1,CC(=O)Cl.CC1(NC(=O)c2ccccc2)Cc2ccccc2C1>>CC(=O)c1ccc2c(c1)CC(C)(NC(=O)c1ccccc1)C2,,C[N+](=O)[O-],,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080227811A1,C=O.COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ccnc2cc1OCC1(NCC2CC2)CC1>>COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ccnc2cc1OCC1(N(C)CC2CC2)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120329785A1,CC(C)N1CCN(c2ccc(N)cc2)CC1.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1>>COc1ccc2nc(Nc3ccc(N4CCN(C(C)C)CC4)cc3)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US20080312226A1,N=C(N)N1CCC(O)CC1.SC(Cl)(Cl)Cl>>OC1CCN(c2nsc(Cl)n2)CC1,,ClCCl,O,Cl,[Na+].[OH-],val
US04644071,CCCc1c(OCCCCCOc2coc(C(=O)OC)cc2=O)ccc(C(C)=O)c1O>>CCCc1c(OCCCCCOc2coc(C(=O)O)cc2=O)ccc(C(C)=O)c1O,,CCO,O,Cl,[Na+].[OH-],val
US20050070441A1,CCN=C=O.FC(F)(F)c1cc(Cl)c(Oc2cc(-c3ccc(Cl)cc3)[nH]n2)c(Cl)c1>>CCNC(=O)n1nc(Oc2c(Cl)cc(C(F)(F)F)cc2Cl)cc1-c1ccc(Cl)cc1,,CCOC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130197013A1,CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(-c2cccc(C(F)(F)F)c2)cc1.Cl>>Cl.N[C@@H]1C[C@H]1c1ccc(-c2cccc(C(F)(F)F)c2)cc1,,CCOCC,,,,val
US20160222033A1,CCNC(=O)c1c(Cl)sc2nc(CCl)cc(=O)n12.FC(F)(F)c1cc(Cl)[nH]n1>>CCNC(=O)c1c(Cl)sc2nc(Cn3nc(C(F)(F)F)cc3Cl)cc(=O)n12,,CC#N,,[I-].[K+],,val
US20040204448A1,CNC.O=C(O)CC(c1ccc(OC(F)F)c(OC(F)F)c1)N1Cc2cccc(NC(=O)C3CC3)c2C1=O>>CN(C)C(=O)CC(c1ccc(OC(F)F)c(OC(F)F)c1)N1Cc2cccc(NC(=O)C3CC3)c2C1=O,,C1CCOC1,C1CCOC1,O,O=C(n1ccnc1)n1ccnc1,val
US04026891,NN.Nc1ccc(C(=O)CCC(=O)O)cc1[N+](=O)[O-]>>Nc1ccc(C2=NNC(=O)CC2)cc1[N+](=O)[O-],,CC(=O)O,,O,,val
US20160145247A1,CCC[C@@H](N)c1cccc(-c2cccc(COc3ccccc3CC(=O)OC)c2)c1F>>CCC[C@@H](N)c1cccc(-c2cccc(COc3ccccc3CC(=O)O)c2)c1F,,CO,,Cl,[Li+].[OH-],val
US06201006B1,CCn1c(CC[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(CCO)C(=O)O)cc2ccc(C(=N)N)cc21>>CCn1c(CC[C@@H]2CCCN2C(=O)[C@H]2CCCN2C2CCOC2=O)cc2ccc(C(=N)N)cc21,,Cl,,,,val
US20030069299A1,NCCCCC(=O)O.O=Cc1ccc([N+](=O)[O-])cc1>>O=C1CCCCN1Cc1ccc([N+](=O)[O-])cc1,,CO,O,Cl,[BH3-]C#N.[Na+],val
US20130203776A1,COc1ncc(F)cc1[C@H]1COC(=O)N1c1ccn2ncc(C(=O)NCCCCl)c2n1>>O=C(NCCCCl)c1cnn2ccc(N3C(=O)OC[C@@H]3c3cc(F)c[nH]c3=O)nc12,,C1COCCO1,Cl,,,val
US04743640,CC(=O)CC(C)=O.CCCCCCCCCCCCCCCCOC(=O)Cl>>CCCCCCCCCCCCCCCCOC(=O)OC(C)=CC(C)=O,,CCOCC,,CCN(CC)CC,,val
US20060281784A1,CC(C)CCN(CCC(C)C)C(=O)c1ccc([N+](=O)[O-])c(NCCCN2CCCCC2)c1>>CC(C)CCN(CCC(C)C)Cc1ccc(N)c(NCCCN2CCCCC2)c1,,ClCCl,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20130225524A1,COC(=O)c1cc(N)cc(Br)c1.OB(O)c1ccccc1>>COC(=O)c1cc(N)cc(-c2ccccc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20160108040A1,CC(C)(C)c1cc(N)n(-c2cnnc(OCCO)c2)n1.O=C(Cl)OCC(Cl)(Cl)Cl>>CC(C)(C)c1cc(NC(=O)OCC(Cl)(Cl)Cl)n(-c2cnnc(OCCO)c2)n1,,CCOC(C)=O,,[Na+].[OH-],,val
US20120202690A1,COC(=O)c1nccc2[nH]ccc12.O=C1CCC(=O)N1Cl>>COC(=O)c1nccc2[nH]cc(Cl)c12,,CN(C)C=O,,O,,val
US04602109,Cc1cc(O)ccc1N.O=S(=O)(c1ccc(Cl)cc1)c1ccc(Cl)cc1>>Cc1cc(Oc2ccc(S(=O)(=O)c3ccc(Cl)cc3)cc2)ccc1N,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05684017,COc1ccc(C(=O)c2cc(=O)c3ccccc3o2)cc1.O=C=NS(=O)(=O)c1ccccc1>>COc1ccc(C(=O)c2cc(=NS(=O)(=O)c3ccccc3)c3ccccc3o2)cc1,,CC#N,,,,val
US20150352090A1,COC(=O)c1ccc(CBr)cc1.O=Cc1cccc(O)c1>>COC(=O)c1ccc(COc2cccc(C=O)c2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080269286A1,Fc1ccc(C2=CCNCC2)cc1Cl>>Fc1ccc(C2CCNCC2)cc1Cl,O=[Pt],CO,,Cl,,val
US20140088075A1,CNCc1ccc(OC)cc1.Cc1cc(F)c(N)cc1-c1cc2cnc(Cl)cc2n(C)c1=O>>COc1ccc(CN(C)c2cc3c(cn2)cc(-c2cc(N)c(F)cc2C)c(=O)n3C)cc1,,CN1CCCC1=O,,C1CCC2=NCCCN2CC1,,val
US05866589,CCNC(=O)C1CCN(Cc2ccccc2)CC1>>CCNCC1CCN(Cc2ccccc2)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100216758A1,COc1ccc(CO)cc1.Fc1cc(Br)ccc1CBr>>COc1ccc(COCc2ccc(Br)cc2F)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20070191395A1,CCOC(C)=N.N#CCC(=O)NN>>Cc1n[nH]c(CC#N)n1,,CO,,Cl,[Na+].[OH-],val
US03957871,O=S(Cl)Cl.OCc1ccc(C#Cc2ccccc2)cc1>>ClCc1ccc(C#Cc2ccccc2)cc1,,ClC(Cl)Cl,,,,val
US20060025400A1,O=C(N1CCc2c(ccc3c2CCC[C@@H]3O)C1)C(F)(F)F.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=N[C@@H]1CCCc2c1ccc1c2CCN(C(=O)C(F)(F)F)C1,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,Cl,val
US20130029971A1,BrC(Br)(Br)Br.O=C(Nc1cc(Cl)ccc1N1CCC(CCO)CC1)c1cccc(Cl)c1>>O=C(Nc1cc(Cl)ccc1N1CCC(CCBr)CC1)c1cccc(Cl)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130072467A1,CN1CC(=N)N(C(=O)c2ccccc2)C1=O.O=CC1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1>>CN1C(=O)N=C(N)/C1=C\C1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1,,CCO,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US06262103B1,CCOC(=NNC=O)c1sc(SC)c2c1CC(C)(C)CC2=O.CN>>CSc1sc(-c2nncn2C)c2c1C(=O)CC(C)(C)C2,,CCO,,,,val
US04894383,CCCCCC(=O)C=Cc1ccc(Cl)cc1>>CCCCCC(=O)CCc1ccc(Cl)cc1,[Ni],Cc1ccccc1,,,,val
US04973586,COc1cc2c(cc1Cl)C=CN[C@@H]1Cc3ccccc3[C@@H]21>>COc1cc2c(cc1Cl)CCN[C@@H]1Cc3ccccc3[C@@H]21,,CCO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20060122399A1,CCOC(OCC)c1nc(C(F)F)nn1C>>Cn1nc(C(F)F)nc1C=O,,O,,Cl,,val
US20060264435A1,Cc1cnc(N)c(Br)c1.O=C(O)COc1ccc(C(F)(F)F)cc1B(O)O>>Cc1cnc(N)c(-c2cc(C(F)(F)F)ccc2OCC(=O)O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US04561876,CCC1(N)COCOC1.O=C(Cl)CCl>>CCC1(NC(=O)CCl)COCOC1,,ClCCl,,O,[Na+].[OH-],val
US04030932,CCN1Cc2ccccc2C1=O.COS(=O)(=O)F>>CC[N+]1=C(OC)c2ccccc2C1.O=S(=O)([O-])F,,ClCCl,,,,val
US20090042852A1,CCOC(=O)c1cc(C#N)c(N2CCNCC2)nc1C(F)(F)F.O=C=NS(=O)(=O)c1ccccc1Cl>>CCOC(=O)c1cc(C#N)c(N2CCN(C(=O)NS(=O)(=O)c3ccccc3Cl)CC2)nc1C(F)(F)F,,ClCCl,,,,val
US20100152181A1,COC(C)(OC)N(C)C.Nc1ccc(Cl)nn1>>C/C(=N\c1ccc(Cl)nn1)N(C)C,,Cc1ccccc1,,,,val
US04387103,CCCOC(=O)CCc1ccc(O)cc1.ClCC1CO1>>CCCOC(=O)CCc1ccc(OCC2CO2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150166480A1,CC(C)(C)OC(=O)N1CCC(COc2ccc(Br)c(C#N)c2)CC1.Cl>>Cl.N#Cc1cc(OCC2CCNCC2)ccc1Br,,ClCCl,,C1COCCO1,,val
US20090069326A1,CC(C)[Si](Cl)(C(C)C)C(C)C.O=C1[C@H](Cc2c(Cl)cc(OCc3ccccc3)cc2Cl)CCN1[C@@H]1CC[C@@H](O)CC1>>CC(C)[Si](O[C@@H]1CC[C@@H](N2CC[C@@H](Cc3c(Cl)cc(OCc4ccccc4)cc3Cl)C2=O)CC1)(C(C)C)C(C)C,,CN(C)C=O,,c1c[nH]cn1,,val
US20150353499A1,COC(Cl)Cl.COc1ccc2c(Br)cccc2c1>>COc1ccc2c(Br)cccc2c1C=O,Cl[Ti](Cl)(Cl)Cl,Cl,ClCCl,,,val
US20090299072A1,CC(C)(CCBr)CCBr.CCOC(=O)Cc1cc(Cl)c(OCC(F)(F)F)c(-c2ccc(C(F)(F)F)cc2)c1>>CCOC(=O)C1(c2cc(Cl)c(OCC(F)(F)F)c(-c3ccc(C(F)(F)F)cc3)c2)CCC(C)(C)CC1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US04535171,N#Cc1ccc2c(c1)S(=O)(=O)c1ccccc1C=C2.O=CO>>O=Cc1ccc2c(c1)S(=O)(=O)c1ccccc1C=C2,,O,,,,val
US20120082702A1,C1CCNCC1.CS(=O)(=O)c1ccc(Nc2nc(Cl)ccc2C(N)=O)cc1>>CS(=O)(=O)c1ccc(Nc2nc(N3CCCCC3)ccc2C(N)=O)cc1,,CCOC(C)=O,,,,val
US20100298324A1,CN(C)c1cccc(CN)c1.COc1cc(OC)nc(-n2c(=S)[nH]c3cc(C(=O)O)ccc3c2=O)n1>>COc1cc(OC)nc(-n2c(=S)[nH]c3cc(C(=O)NCc4cccc(N(C)C)c4)ccc3c2=O)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110207728A1,CCOC(=O)c1cc([N+](=O)[O-])c[nH]1.COc1ccc(C(=O)CBr)cc1>>CCOC(=O)c1cc([N+](=O)[O-])cn1CC(=O)c1ccc(OC)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20070142448A1,Cc1ccc(S(=O)(=O)Cl)cc1.Cc1nc2c(OCc3ccccc3)cc(C(=O)N(C)C)cc2[nH]1>>Cc1ccc(S(=O)(=O)n2c(C)nc3c(OCc4ccccc4)cc(C(=O)N(C)C)cc32)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20100273764A1,COc1cc(Nc2ncc(C(C)=O)cc2-c2nc(C)nc(N)n2)cnc1Cl.C[Mg]Br>>COc1cc(Nc2ncc(C(C)(C)O)cc2-c2nc(C)nc(N)n2)cnc1Cl,,C1CCOC1,,,,val
US20150376208A1,N.O=[N+]([O-])c1ccc(C(F)(F)F)c(F)c1>>Nc1cc([N+](=O)[O-])ccc1C(F)(F)F,,CO,O,,,val
US04336379,CI.Cc1noc(C)c1-c1cc2ccccc2[nH]1>>CCc1onc(C)c1-c1cc2ccccc2[nH]1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20120264737A1,COC(=O)c1cc(-c2nc3c([nH]2)COCC3(C)C)c(C)cc1C>>Cc1cc(C)c(-c2nc3c([nH]2)COCC3(C)C)cc1C(=O)O,,C1CCOC1,,[Li+].[OH-],,val
US20130102586A1,COc1ccc(Cn2nc(C)c3cc(-c4cccc(CN5CCN(C)CC5)c4)cnc32)cc1>>Cc1n[nH]c2ncc(-c3cccc(CN4CCN(C)CC4)c3)cc12,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20100331297A1,Nc1ncnc2[nH]nc(I)c12.OCC1CC1>>Nc1ncnc2c1c(I)nn2CC1CC1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04945160,CCCC[Sn](CCCC)(CCCC)C1(O)CCN(C(C)=O)CC1>>CCCC[Sn](CCCC)(CCCC)C1=CCN(C(C)=O)CC1,,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US20090275623A1,C1COCCO1.Nc1nc2c(C(F)(F)F)cc3[nH]ncc3c2s1.O=C(Cl)CCl>>O=C(CCl)Nc1nc2c(C(F)(F)F)cc3c(cnn3C(=O)CCl)c2s1,,C1COCCO1,,,,val
US20110105505A1,CC(C)(C)OC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC(c2nc(-c3ccc4c(c3)C(C)(C)CCC4(C)C)cs2)CC1>>CC1(C)CCC(C)(C)c2cc(-c3csc(C4CCN(C(=O)[C@@H](N)Cc5cnc[nH]5)CC4)n3)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US04072674,COC(=O)[C@@H]1NC(=O)[C@@H]1N=[N+]=[N-]>>COC(=O)[C@@H]1NC(=O)[C@@H]1N,[Pd],CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110003787A1,COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(-c3nccs3)n2C(=O)OC(C)(C)C)c1>>COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(-c3nccs3)[nH]2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120028951A1,CN(C)C=CC(=O)c1nn(-c2ccccc2)ccc1=O.NNc1ccccc1>>O=c1ccn(-c2ccccc2)nc1-c1ccnn1-c1ccccc1,,CO,,,,val
US20080021032A1,CS(=O)(=O)c1ccc(Cn2ccc(N)n2)cc1.Cn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)n1>>CS(=O)(=O)c1ccc(Cn2ccc(NC(=O)[C@H](CC3CCCC3)c3ccc(S(C)(=O)=O)c(Cl)c3)n2)cc1,,ClCCl,,Cc1cccc(C)n1,O=C(Cl)C(=O)Cl,val
US20150018547A1,CI.COC(=O)C1(CO)COc2cc(OCc3ccc(Cl)cc3Cl)ccc21>>COCC1(C(=O)OC)COc2cc(OCc3ccc(Cl)cc3Cl)ccc21,O=[Ag-],Cc1ccccc1,,,,val
US05639752,CN(C)CCc1c[nH]c2ccc(N)cc12.O=[N+]([O-])c1cccc([N+](=O)[O-])c1Cl>>CN(C)CCc1c[nH]c2ccc(Nc3c([N+](=O)[O-])cccc3[N+](=O)[O-])cc12,,C1CCOC1,,CCN(CC)CC,,val
US20070254937A1,Br[Mg]c1ccccc1.CC(C)(C)OC(=O)n1nc(-c2cc3cc(C=O)ccc3n2C(=O)OC(C)(C)C)c2sccc21>>CC(C)(C)OC(=O)n1nc(-c2cc3cc(C(O)c4ccccc4)ccc3n2C(=O)OC(C)(C)C)c2sccc21,,C1CCOC1,,,,val
US20030153604A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccc(-c2ccnc(C#N)c2)cc1>>COC(=O)c1ccc(-c2ccnc(CNC(=O)OC(C)(C)C)c2)cc1,[Pd],C1CCOC1,,,,val
US20160221945A1,C=CCC1COC/C1=N\O>>C=CCC1COCC1N,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120108619A1,CCO.O=C(Cl)c1ccc2ccnc(Cl)c2c1>>CCOC(=O)c1ccc2ccnc(Cl)c2c1,,C1CCOC1,,CCN(CC)CC,,val
US06147090,CCOC(=O)N1c2cc(CBr)c(OC)cc2[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)OC)C[C@@H]1C.C[S-]>>CCOC(=O)N1c2cc(CSC)c(OC)cc2[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)OC)C[C@@H]1C,,CN(C)C=O,,O,,val
US06903087B2,CC1=C(c2ccc(C(=O)N3Cc4ccc(C(=O)O)n4Cc4ccccc43)cc2C)CCC[C@H]1O.CCN(C(C)C)C(C)C.CNCc1cccnc1>>CCN(C(=O)c1ccc2n1Cc1ccccc1N(C(=O)c1ccc(C3=C(C)[C@H](O)CCC3)c(C)c1)C2)c1cccnc1,,CCOC(C)=O,,On1nnc2ccccc21,,val
US20160251380A1,CC(C)(C)OC(=O)NC[C@@H]1C=C2C=COCC3=C2B(OC3)O1.O=C1CCC(=O)N1I>>CC(C)(C)OC(=O)NC[C@@H]1OB2OCC3=C2C(=C1I)C=COC3,,CC(=O)O,,,,val
US20060287329A1,Nc1ccc(Cl)cn1.O=c1[nH]c2cc3ccccc3cc2c(=O)o1>>Nc1cc2ccccc2cc1C(=O)Nc1ccc(Cl)cn1,CN(C)c1ccncc1,Cc1ccccc1C,,,,val
US20110263592A1,Fc1ccc(CCN2CCNCC2)c(F)c1.O=C(O)c1cccn2ccnc12>>O=C(c1cccn2ccnc12)N1CCN(CCc2ccc(F)cc2F)CC1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US05516751,COC(=O)c1cc(NC(C)=O)c([N+](=O)[O-])cc1C(=O)OC.Cc1ccccc1S(=O)(=O)O>>COC(=O)c1cc2nc(C)[nH]c2cc1C(=O)OC.Cc1ccc(S(=O)(=O)O)cc1,[Pt],Cc1ccccc1,,CO,,val
US06002008,CCOc1cc2ncc(C#N)c(O)c2cc1[N+](=O)[O-].O=P(Cl)(Cl)Cl>>CCOc1cc2ncc(C#N)c(Cl)c2cc1[N+](=O)[O-],,CCCCCC,,ClP(Cl)(Cl)(Cl)Cl,,val
US06537948B1,CCOC(=O)/C=C(\N)C(F)(F)F.COC(=O)COc1ncccc1Oc1cc(N=C=O)c(F)cc1Cl>>COC(=O)COc1ncccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(F)cc1Cl,,CN(C)C=O,,Cl,[H-].[Na+],val
US05208247,CCCCCCCCCCCCCCOc1ccc(CC(=O)Cl)cc1.NCCc1ccccn1>>CCCCCCCCCCCCCCOc1ccc(CC(=O)NCCc2ccccn2)cc1,,ClC(Cl)Cl,ClCCl,c1ccncc1,,val
US08461164B2,CC(=O)C(C)=O.Cc1nc(N)c(N)c(Cl)n1>>Cc1nc(=O)c2nc(C)c(C)nc2[nH]1,,CCOCC,,CCCCO,,val
US20080287457A1,COc1ccc(-c2nnc(C3CCN(Cc4ccc(-c5nc6cc[nH]c(=O)c6cc5-c5ccccc5)cc4)CC3)[nH]2)cn1.O=C(O)C(F)(F)F>>COc1ccc(-c2nnc(C3CCN(Cc4ccc(-c5nc6cc[nH]c(=O)c6cc5-c5ccccc5)cc4)CC3)[nH]2)cn1.O=C(O)C(F)(F)F,,CO,,,,val
US20100099695A1,COc1ccc2nc(Br)c(B(O)O)cc2c1.OO>>COc1ccc2nc(Br)c(O)cc2c1,,CCOCC,O,[Cl-].[NH4+],,val
US20070054916A1,CC(C)(C)c1ccc(NC(=O)CN2CCCC2)c([N+](=O)[O-])c1>>CC(C)(C)c1ccc(NC(=O)CN2CCCC2)c(N)c1,O=[Pt]=O,CCOC(C)=O,,,,val
US20120184508A1,CC(C)(C)OC(=O)NCC(Nc1nccc(-c2n[nH]c3nc(NCCN4CCOCC4)ncc23)n1)c1cccc(Cl)c1>>NCC(Nc1nccc(-c2n[nH]c3nc(NCCN4CCOCC4)ncc23)n1)c1cccc(Cl)c1,,CCO,,Cl,,val
US05106862,O=[N+]([O-])c1cccc(O)c1[N+](=O)[O-]>>Nc1cccc(O)c1N,[Pd],CCO,,[H][H],,val
US20150111876A1,CC(=O)Cl.NC(=O)c1cc(C2CCCCC2)sc1N>>Cc1nc2sc(C3CCCCC3)cc2c(=O)[nH]1,,C1CCOC1,,,,val
US20070213339A1,CCOC(=O)c1cn(-c2ccc(CN3CC[C@H](O)C3)cc2)c2c(Cl)c(F)c(F)cc2c1=O.CS(C)=O.c1cnc(N2CCNCC2)nc1>>CCOC(=O)c1cn(-c2ccc(CN3CC[C@H](O)C3)cc2)c2c(Cl)c(N3CCN(c4ccccn4)CC3)c(F)cc2c1=O,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20160002204A1,CC(C)CS(=O)(=O)Cl.Nc1ccn(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)c(=O)n1>>CC(C)CS(=O)(=O)Nc1ccn(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)c(=O)n1,,C1CCOC1,CS(C)=O,[H-].[Na+],,val
US05620989,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OC[C@]1(c2ccccc2)CCCN1>>CC(C)(C)OC(=O)N1CCC[C@]1(CO)c1ccccc1,,ClCCl,,,,val
US04420327,Nc1ccc(Cl)c(OC2CCCC2=O)c1.O=C1OC(=O)C2=C1CCCC2>>O=C1CCCC1Oc1cc(N2C(=O)C3=C(CCCC3)C2=O)ccc1Cl,,CC(=O)O,,,,val
US20150031670A1,BrCC1CCCCC1.O=C1CCCCN1>>O=C1CCCCN1CC1CCCCC1,,CN(C)C=O,,[H-].[Na+],,val
US20130150339A1,Oc1ccnc2cc(Cl)nc(Cl)c12>>Oc1ccnc2cc(Cl)ncc12,[Zn],CO,,CC(=O)O,,val
US20090105249A1,ClCc1ccc(-c2ccccc2)cc1.O=S(=O)(c1ccccc1)N(C1CCNCC1)C1CC1>>O=S(=O)(c1ccccc1)N(C1CC1)C1CCN(Cc2ccc(-c3ccccc3)cc2)CC1,,CN(C)C=O,,CCN(CC)CC,,val
US20030187002A1,COc1cc(C#N)c(N=CN(C)C)cc1OCCCN1CCOCC1.Nc1nccs1>>COc1cc2c(-c3cnc(N)s3)ncnc2cc1OCCCN1CCOCC1,,CC(=O)O,,,,val
US20060258672A1,CNOC.COC(=O)C1CN(c2ncccn2)C1>>CON(C)C(=O)C1CN(c2ncccn2)C1,,C1CCOC1,,CC(C)[Mg]Cl,Cl,val
US20110288296A1,Clc1ccc(Cl)nn1.II>>Clc1cc(I)c(Cl)nn1,,C1CCOC1,,[Cl-].[Li+],,val
US20030065176A1,Cc1cc(I)ccc1O.N#C[Cu]>>Cc1cc(C#N)ccc1O,,CN(C)C=O,,,,val
US20070185089A1,CN.O=C(O)c1ccc(Br)c(F)c1>>CNC(=O)c1ccc(Br)c(F)c1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20080171743A1,CCN=C=O.C[C@H]1COCCN1c1cc(CO[Si](C)(C)C(C)(C)C)nc(-c2ccc(N)cc2)n1>>CCNC(=O)Nc1ccc(-c2nc(CO[Si](C)(C)C(C)(C)C)cc(N3CCOC[C@@H]3C)n2)cc1,,C1COCCO1,,,,val
US20040023974A1,COc1ccc(CN2C(=O)CN(Cc3ccc(C(=O)O)cc3)S2(=O)=O)c(OC)c1.O=S(Cl)Cl>>COc1ccc(CN2C(=O)CN(Cc3ccc(C(=O)Cl)cc3)S2(=O)=O)c(OC)c1,,Cc1ccccc1,,,,val
US20020107273A1,CCC1Nc2ccc(OC)cc2N1c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1>>CCc1nc2cc(O)ccc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1,,Br,,[Na+].[OH-],,val
US05306830,O=[N+]([O-])C1COc2c(Br)cccc2C1>>NC1COc2c(Br)cccc2C1,[Zn],CC(=O)O,,,,val
US06699862B1,Cc1ccc(C#N)cc1[N+](=O)[O-].N#Cc1ccc(C=O)cc1>>N#Cc1ccc(C(O)Cc2ccc(C#N)cc2[N+](=O)[O-])cc1,,CS(C)=O,,C[O-].[Na+],,val
US20110230482A1,CC(C)(C)OC(=O)N(Cc1ccc(F)cc1)c1nc(Cl)c(C=O)s1.CC(C)[Si](C(C)C)(C(C)C)n1cc(I)c2cc(Cl)cnc21>>Fc1ccc(CNc2ncc(Cc3c[nH]c4ncc(Cl)cc34)s2)cc1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20150353581A1,CC(N)(C#N)COc1ccc2c(c1F)B(O)OC2.O=C(Cl)c1ccc(OC(F)(F)F)cc1>>CC(C#N)(COc1ccc2c(c1F)B(O)OC2)NC(=O)c1ccc(OC(F)(F)F)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US07612075B2,CC(C)(C)OC(=O)n1c(CN2CCN(C(=O)OCc3ccccc3)CC2=O)cc2c(Cl)nccc21>>O=C1CN(C(=O)OCc2ccccc2)CCN1Cc1cc2c(Cl)nccc2[nH]1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050267093A1,CNC1CCC(C)CC1.CS(=O)(=O)OCc1ccc(/C=C/C(=O)Nc2ccc(-c3ccc(Cl)cc3)cc2)cc1>>CC1CCC(N(C)Cc2ccc(/C=C/C(=O)Nc3ccc(-c4ccc(Cl)cc4)cc3)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20080293716A1,COC(=O)c1ccc(Br)s1.OB(O)c1ccncc1>>O=C(O)c1ccc(-c2ccncc2)s1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CO,COCCOC,[Na+].[OH-],,val
US04021225,CN=C=O.CNc1nnc(S)s1>>CNC(=O)N(C)c1nnc(S)s1,C1COCCO1,CCN(CC)CC,,,,val
US05254685,CC(=O)Cc1c([N+](=O)[O-])ccc(F)c1F>>CC(O)Cc1c([N+](=O)[O-])ccc(F)c1F,,CO,,Cl,[BH4-].[Na+],val
US20100063013A1,CC(C)(F)C[C@@H](CO)NC(=O)OCc1ccccc1>>CC(C)(F)C[C@H](N)CO,[Pd],CCO,,,,val
US20060148823A1,CC(C)(C)OC(=O)N1CCC(N2c3ccccc3Oc3cc(-c4nnn[nH]4)ccc32)CC1>>c1ccc2c(c1)Oc1cc(-c3nnn[nH]3)ccc1N2C1CCNCC1,,CN(C)C=O,,Cl,,val
US04379154,CN.CSC(=S)C1(c2cccnc2)CCCS1>>CNC(=S)C1(c2cccnc2)CCCS1,,CCO,,C,,val
US08481749B2,Cn1nnnc1N.O=C(Cl)c1ccc(Cl)cc1Cl>>Cn1nnnc1NC(=O)c1ccc(Cl)cc1Cl,,CC#N,,O,c1ccncc1,val
US20160015712A1,COCCOc1ccc(-n2nnc3cnc(Cl)nc32)cc1.N[C@@H]1CC[C@@H](C(=O)O)C1>>COCCOc1ccc(-n2nnc3cnc(N[C@@H]4CC[C@@H](C(=O)O)C4)nc32)cc1,,COCCO,,CCN(C(C)C)C(C)C,Cl,val
US20140045852A1,CC(=O)O.CC(C)S(=O)(=O)Cc1cccc([N+](=O)[O-])c1>>CC(=O)Nc1cccc(CS(=O)(=O)C(C)C)c1,[Fe],,,ClCCl,O,val
US20100152450A1,CC(C)(C)OC(=O)N1CCC(CCO)CC1.O=C1CCCCC1>>CC(C)(C)OC(=O)N1CCC(CCOC2CCCCC2)CC1,,C[N+](=O)[O-],,CC[SiH](CC)CC,,val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2cc(O)c(Cl)c3c2C(=O)NC3)cc2cc(CN3CCN(CCO)CC3)ccc21.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)n1c(-c2cc(OS(C)(=O)=O)c(Cl)c3c2C(=O)NC3)cc2cc(CN3CCN(CCO)CC3)ccc21,,ClCCl,,CCN(CC)CC,,val
US20020147200A1,Clc1cncc(Cl)n1.OCc1cccnc1>>Clc1cncc(OCc2cccnc2)n1,,C1COCCO1,,[H-].[Na+],,val
US20140350019A1,Cc1cc(CNc2c(C)ccc(OCC(=O)OC(C)C)c2C)c(F)c(-c2cccc(F)c2)c1>>Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1,,C1CCOC1,,[Li+].[OH-],,val
US05739351,CC(C)(C)OC(=O)N1CC2CC(CO)CC(O)(c3ccccc3F)C2C1>>OC1CCCC2CNCC12,,C1COCCO1,,Cl,,val
US20090042918A1,NCc1ccccc1.Nc1nc(Cl)ncc1-c1nnn[nH]1>>Nc1nc(NCc2ccccc2)ncc1-c1nnn[nH]1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20150111866A1,COC(=O)c1cc(C)c(-c2cnc(OC)c(-c3cnc(S(C)(=O)=O)nc3CN3C(=O)O[C@H](c4cc(F)cc(C(F)(F)F)c4)[C@@H]3C)c2)c(C)c1.FC1CNC1>>COC(=O)c1cc(C)c(-c2cnc(OC)c(-c3cnc(N4CC(F)C4)nc3CN3C(=O)O[C@H](c4cc(F)cc(C(F)(F)F)c4)[C@@H]3C)c2)c(C)c1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,Cl,val
US20070142448A1,Cc1ccc(S(=O)(=O)n2c(C)nc3c(O)cc(C(=O)N(C)C)cc32)cc1.OC1CCOc2cc(F)cc(F)c21>>Cc1ccc(S(=O)(=O)n2c(C)nc3c(O[C@H]4CCOc5cc(F)cc(F)c54)cc(C(=O)N(C)C)cc32)cc1,,Cc1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20120202776A1,CC(C)S(=O)(=O)c1ccccc1N.FC(F)(F)c1cnc(Cl)nc1Cl>>CC(C)S(=O)(=O)c1ccccc1Nc1nc(Cl)ncc1C(F)(F)F,,CN(C)C=O,,[H-].[Na+],,val
US20160008322A1,C1CCC2OC2C1.C1COCCN1>>O[C@H]1CCCC[C@@H]1N1CCOCC1,,O,,,,val
US20150274777A1,ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.c1ccc2c(c1)CNC2>>O=C(Cl)N1Cc2ccccc2C1,,ClCCl,,c1ccncc1,,val
US20030187002A1,O=C(Cc1cnc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)s1)Nc1ccc(F)c(Cl)c1>>Nc1ncc(CC(=O)Nc2ccc(F)c(Cl)c2)s1,,O,O=C(O)C(F)(F)F,,,val
US05100893,CO[C@@H]1CN(Cc2ccccc2)CC[C@@H]1CCO>>CO[C@@H]1CNCC[C@@H]1CCO,[Pd],CO,,[H][H],,val
US20130157298A1,CC(C)(C)N=C=O.NCc1cccc(-c2cc(-c3nnn[nH]3)ccc2O)c1>>CC(C)(C)NC(=O)NCc1cccc(-c2cc(-c3nnn[nH]3)ccc2O)c1,,CN(C)C=O,O,CCN(CC)CC,CCOC(C)=O,val
US20060135530A1,CCOC(=O)CCCCBr.Cc1ccc(-c2c(CNC(=O)OC(C)(C)C)c(CC(C)C)nc3ccc(O)cc23)cc1>>CCOC(=O)CCCCOc1ccc2nc(CC(C)C)c(CNC(=O)OC(C)(C)C)c(-c3ccc(C)cc3)c2c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US03952001,CCCSc1nc[nH]n1.CCN(CC)C(=O)Cl>>CCCSc1ncn(C(=O)N(CC)CC)n1,,CCN(CC)CC,,C1CCOC1,,val
US20100016330A1,C[C@H]1CNCCN1C(=O)OC(C)(C)C.O=S(=O)(Cl)c1cc(C(F)(F)F)ccc1Br>>C[C@H]1CN(S(=O)(=O)c2cc(C(F)(F)F)ccc2Br)CCN1C(=O)OC(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090286827A1,CCCI.Clc1ccc(Nc2ncc(-c3nnn[nH]3)cc2Cl)cc1>>CCCn1nnnc1-c1cnc(N)c(Cl)c1,,CN(C)C=O,O,[H-].[Na+],,val
US03951976,CCCN1CCC(O)N(c2nnc(SC)s2)C1=O.O=C=NC1CCCCC1>>CCCN1CCC(OC(=O)NC2CCCCC2)N(c2nnc(SC)s2)C1=O,CCN(CC)CC,,,,,val
US05204344,CC(=O)Nc1ccc(O)cc1.ClCc1ccc2ccccc2n1>>CC(=O)Nc1ccc(OCc2ccc3ccccc3n2)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100280001A1,CCCCc1nc2c(N)nc3ccccc3c2n1CCCNC1CCN(C)CC1.O=Cc1ccc(CC(=O)O)cc1>>CCCCc1nc2c(N)nc3ccccc3c2n1CCCN(Cc1ccc(CC(=O)O)cc1)C1CCN(C)CC1,,CN1CCCC1=O,CO,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04178449,CN(C)C=CC(=O)c1cccc(C(F)(F)F)c1.Nc1nc[nH]c1Cl>>FC(F)(F)c1cccc(-c2ccnc3c(Cl)ncn23)c1,,CC(=O)O,,,,val
US20070254940A1,CN(C(=O)OC(C)(C)C)C1CC=C(c2c[nH]c3cc([N+](=O)[O-])ccc23)CC1.CO>>CCN(C(=O)OC(C)(C)C)C1CC=C(c2c[nH]c3cc(N)ccc23)CC1,[Ni],,,NN,O,val
US05240928,CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.O=C(Cl)OCc1ccccc1>>CCCCc1nc2ccc(NC(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20030203915A1,CC(C)(S)CN.O=C1OC(=O)c2ccccc21>>CC(C)(S)CN1C(=O)c2ccccc2C1=O,,CC(=O)O,,,,val
US20060046978A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC(CC(=O)O)Cc1ccccc1>>CC(C)(C)OC(=O)NC(CC(=O)O)Cc1ccccc1,,C1COCCO1,,O,[Na+].[OH-],val
US20150368267A1,CC(C)(C)OC(=O)c1ccc(Nc2nc(NCc3ccc(O)cc3)nc(OCC(F)(F)F)n2)cc1>>O=C(O)c1ccc(Nc2nc(NCc3ccc(O)cc3)nc(OCC(F)(F)F)n2)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080015187A1,CCOC(=O)c1nn2c(c1O)C(=O)N(C)C[C@@H]2c1ccccc1>>CN1C[C@H](c2ccccc2)n2nc(C(=O)O)c(O)c2C1=O,,CO,,Cl,[Na+].[OH-],val
US05864039,COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCN)CC1.Cn1nc(C(=O)O)c2ccccc21>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCNC(=O)c2nn(C)c3ccccc23)CC1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20070191447A1,COC(=O)N1CCCc2cc(Br)cc([N+](=O)[O-])c21>>O=c1[nH]c2cc(Br)cc3c2n1CCC3,,CC(=O)O,,CCOC(C)=O,,val
US05576343,CCOC(=N)COc1ccc(C(C(=O)OCC)C(=O)OCC)cc1.NCCN>>CCOC(=O)C(C(=O)OCC)c1ccc(OCC2=NCCN2)cc1,,O,,CCO,Cl,val
US20130116235A1,CC1Cn2nc([N+](=O)[O-])cc2CN1C>>CC1Cn2nc(N)cc2CN1C,[Ni],CO,,[H][H],,val
US20130059856A1,CS(=O)(=O)Cl.OCc1ccncc1>>CS(=O)(=O)OCc1ccncc1,,ClCCl,,CCN(CC)CC,O,val
US20070185171A1,CC(C)(C)C(=O)Cl.Nc1cc([N+](=O)[O-])ccc1Cl>>CC(C)(C)C(=O)Nc1cc([N+](=O)[O-])ccc1Cl,,ClCCl,,,,val
US05556864,CN1CCCC1CCO.Oc1ccccc1CCCCc1ccccc1>>CN1CCCC1CCOc1ccccc1CCCCc1ccccc1,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110178082A1,CCN(C(C)C)C(C)C.COC(=O)CC(=O)CC(=O)OC.NCc1ccccc1>>COC(=O)Cc1cc(O)n(Cc2ccccc2)n1,,Cc1ccccc1,,Cl,Cl,val
US04230707,CCOC(=O)c1cc(C(C)C)sc1N.NC(=O)c1ccc(Cl)nc1>>CC(C)c1cc2c(=O)n3cc(C(N)=O)ccc3nc2s1,,CO,,,,val
US05856529,OCc1cccc2c1CCCO2>>O=Cc1cccc2c1CCCO2,,CCN(CC)CC,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US05962458,O=S(Cl)Cl.OCCOc1ccccn1>>Cl.ClCCOc1ccccn1,,ClC(Cl)Cl,,,,val
US20040077605A1,CC(C)(C)OC(=O)Nc1ccc(-c2cnco2)c2ccccc12>>Nc1ccc(-c2cnco2)c2ccccc12,,O=C(O)C(F)(F)F,,,,val
US20100029722A1,Cc1nc(C#N)sc1C(=O)NCc1ccccc1.NNC(=O)Cc1ccccc1>>Cc1nc(-c2n[nH]c(Cc3ccccc3)n2)sc1C(=O)NCc1ccccc1,,CCCCO,,O=C([O-])[O-].[K+].[K+],,val
US20090221551A1,CC(C)(C)OC(=O)NCCCNc1c(N)cnc2cc(Br)ccc12.S=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)NCCCn1c(=S)[nH]c2cnc3cc(Br)ccc3c21,,C1CCOC1,,,,val
US20050080124A1,COc1ccc(N)cc1-c1ccnn1C(C)C.O=C=Nc1ccc(Cl)cc1>>COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1ccnn1C(C)C,,ClCCl,,,,val
US20110098323A1,COC(=O)CS.S=C=Nc1cccnc1>>O=C1CSC(=S)N1c1cccnc1,,ClCCl,ClCCl,CCN(CC)CC,,val
US20120252801A1,CCN1CC(C)(c2ccccc2)OC(=O)C1CC(=O)OC(C)(C)C>>CCN1CC(C)(c2ccccc2)OC(=O)C1CC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070173521A1,C=C(B1OC(C)(C)C(C)(C)O1)c1ccccc1.COC(=O)c1cc(Br)cc(-c2ccccn2)c1>>C=C(c1ccccc1)c1cc(C(=O)OC)cc(-c2ccccn2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[K+].[K+],val
US20080255197A1,Cc1cnc(CNCCCCS(=O)(=O)c2nc3ccccc3[nH]2)c(C)c1.O=Cc1nccc2ccccc12>>Cc1cnc(CN(CCCCS(=O)(=O)c2nc3ccccc3[nH]2)Cc2nccc3ccccc23)c(C)c1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20020007059A1,Nc1cc(=O)[nH]n1-c1ccccn1.O=C1CCC(=O)C1.O=Cc1ccc(F)c(Br)c1>>O=C1CCC2=C1C(c1ccc(F)c(Br)c1)c1c(n(-c3ccccn3)[nH]c1=O)N2,,CCO,,,,val
US05675023,COc1c(OC(C)C)cc2oc(Oc3ccc(OC(C)C)cc3)cc(=O)c2c1O.Oc1ccc(S)cc1>>COc1c(OC(C)C)cc2oc(Sc3ccc(O)cc3)cc(=O)c2c1O,,CC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120238531A1,O=[N+]([O-])c1ccc(-c2ccccc2)cc1>>ONc1ccc(-c2ccccc2)cc1,[Rh],C1CCOC1,,NN,O,val
US20110046378A1,COCOc1cc(C=O)ccc1OCc1ccccc1.COCOc1ccc(C(C)=O)c(O)c1>>COCOc1ccc(C(=O)/C=C/c2ccc(OCc3ccccc3)c(OCOC)c2)c(O)c1,,CCO,CCOCC,Cl,[K+].[OH-],val
US20110269810A1,O=C1c2ccccc2C(=O)N1CCCCCCNc1ccccc1>>NCCCCCCNc1ccccc1,,CCO,,NN,O,val
US20060046978A1,COC(=O)C(CNC(=O)CCC(NC(=O)OC(C)(C)C)C(=O)N1CCCC1C#N)NC(=O)C(CSC(C)=O)Cc1ccccc1>>COC(=O)C(CNC(=O)CCC(N)C(=O)N1CCCC1C#N)NC(=O)C(CSC(C)=O)Cc1ccccc1,,O=C(O)C(F)(F)F,,O,,val
US20070191439A1,CCOC(=O)C1CCc2nc(N)sc2C1>>CCOC(=O)C1CCc2nc(N)sc2C1,,CO,,Br,O,val
US20010034357A1,C[C@@H](COc1ccc(F)nc1)N(C)C.Cc1ccc(S(=O)(=O)O)cc1>>C[C@@H](COc1ccc(F)nc1)N(C)C.Cc1ccc(S(=O)(=O)O)cc1,,CCOC(C)=O,,CCOCC,O,val
US20160068559A1,COC(=O)C[C@H](NC(=O)Nc1ccc(C(C)(C)C)cc1)C(C)C>>CC(C)[C@H](CCO)NC(=O)Nc1ccc(C(C)(C)C)cc1,,C1CCOC1,,[BH4-].[Li+],,val
US20130190399A1,C1=COCCC1.OCCCCCCCCCl>>ClCCCCCCCCOC1CCCCO1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US07541374B2,COC(=O)c1cnn(CCl)c1.N#CC(C#N)CCC(F)(F)F>>COC(=O)c1cnn(CC(C#N)(C#N)CCC(F)(F)F)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06403586B1,CCOC(=O)c1cc(-c2ccc(OC)cc2)nn(C)c1=O.NCc1ccccc1>>COc1ccc(-c2cc(C(=O)NCc3ccccc3)c(=O)n(C)n2)cc1,,Cc1ccccc1C,,,,val
US20080318933A1,CC(C)(C)OC(=O)N1CCC(N2CCc3cc(S(=O)(=O)c4ccccc4)ccc32)CC1.Cl>>Cl.O=S(=O)(c1ccccc1)c1ccc2c(c1)CCN2C1CCNCC1,,C1COCCO1,,,,val
US20110053907A1,CCOc1cccc2[nH]c(C(F)F)nc12.Clc1nc(Cl)nc(N2CCOCC2)n1>>CCOc1cccc2c1nc(C(F)F)n2-c1nc(Cl)nc(N2CCOCC2)n1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04686213,CCOC(=O)C(=O)c1c[nH]c2c(CC)cccc12.NO>>CCOC(=O)C(=NO)c1c[nH]c2c(CC)cccc12,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20110118257A1,O=C1CCC(=O)N1Br.Oc1c(F)cccc1F>>Oc1c(F)cc(Br)cc1F,,CN(C)C=O,,,,val
US20060009453A1,CC(C)c1cccc(NC(=O)c2ccc([N+](=O)[O-])c(Oc3ncccc3-c3ccncn3)c2)c1>>CC(C)c1cccc(NC(=O)c2ccc(N)c(Oc3ncccc3-c3ccncn3)c2)c1,[Pd],CCOC(C)=O,CO,,,val
US20070135631A1,BrCc1ccc(Br)cc1.COC(=O)C(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(F)c(C(F)(F)F)c1>>COC(=O)C(Cc1ccc(Br)cc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(F)c(C(F)(F)F)c1,,CN(C)C=O,,[H-].[Na+],,val
US20150353553A1,C1CCOC1.C=CCOc1ccc(C)cc1-c1nc2nc(Cl)nc(N[C@H](C)C3CC3)c2n1Cc1ccc(Cl)cc1>>Cc1ccc(OCCCO)c(-c2nc3nc(Cl)nc(N[C@H](C)C4CC4)c3n2Cc2ccc(Cl)cc2)c1,,C1CCOC1,,B,,val
US04333942,CN1CCC(Oc2ccccc2)(c2ccccc2)CC1.O=C(OO)c1cccc(Cl)c1>>C[N+]1([O-])CCC(Oc2ccccc2)(c2ccccc2)CC1,,CO,,,,val
US20060069132A1,CCn1nc(C(C)(C)C)cc1C(=O)Nc1cccc(C(=O)Cl)c1.OCCF>>CCn1nc(C(C)(C)C)cc1C(=O)Nc1cccc(C(=O)OCCF)c1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20080146565A1,CSc1nccc(Cl)n1.c1ccc2c(c1)CCN2>>CSc1nccc(N2CCc3ccccc32)n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20030018203A1,CC(C)(N)Cc1ccc2ccccc2c1.Cl>>CC(C)(N)Cc1ccc2c(c1)CCCC2.Cl,O=[Pt]=O,CC(=O)O,,,,val
US07056932B2,COC(C(=O)NCc1ccc(/C(N)=N\C(=O)OCc2ccccc2)cc1)c1nc2ccccc2n1COCC[Si](C)(C)C>>COC(C(=O)NCc1ccc(/C(N)=N\C(=O)OCc2ccccc2)cc1)c1nc2ccccc2[nH]1,,Cl,,,,val
US04563476,COC(Cl)Cl.COc1ccc2c(c1)CCO2>>COc1cc2c(cc1C=O)OCC2,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20120165309A1,CC(C)(C)OC(=O)NC(C)(C)C(=O)O.N[C@@H]1CC[C@@H](Nc2cc(-n3c(C(F)F)nc4ccccc43)nc(N3CCOCC3)n2)CC1>>CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@@H]1CC[C@@H](Nc2cc(-n3c(C(F)F)nc4ccccc43)nc(N3CCOCC3)n2)CC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.F[P-](F)(F)(F)(F)F,val
US20150025095A1,Cc1nc(Cl)nc(Cl)c1C.NC1CCCCC1>>Cc1nc(Cl)nc(NC2CCCCC2)c1C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110124695A1,BrCc1ccccc1.CC(C)(C)OC(=O)N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)O>>N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])O.[Na+],,val
US20060223801A1,COC(=O)c1cc(OC)nc(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)n1>>COc1cc(C(=O)O)nc(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)n1,,CO,,[Li+].[OH-],,val
US20140088053A1,C[C@]12CC[C@@H]3c4ccc(C(=O)O)cc4CC[C@H]3[C@@H]1C/C(=C\c1cccc(C(N)=O)c1)[C@@H]2O>>C[C@]12CC[C@@H]3c4ccc(C(=O)O)cc4CC[C@H]3[C@@H]1C[C@H](Cc1cccc(C(N)=O)c1)[C@@H]2O,[Pd],CCO,,,,val
US20070032515A1,BrP(Br)Br.Fc1cc(COC2CCCCO2)c(F)c2c1OCCO2>>Fc1cc(CBr)c(F)c2c1OCCO2,,Cc1ccccc1,,,,val
US06511997B1,CI.Cn1nc(NC(=O)Cc2ccccc2)c(-c2ccncc2)c1-c1ccc(F)cc1>>CN(C(=O)Cc1ccccc1)c1nn(C)c(-c2ccc(F)cc2)c1-c1ccncc1,,CN(C)C=O,,[H-].[Na+],,val
US20130310379A1,COC(=O)c1ccc(CNc2ccccc2)cc1>>O=C(O)c1ccc(CNc2ccccc2)cc1,,C1CCOC1,CO,[Li+].[OH-],,val
US20130190355A1,N#Cc1ccc(F)c(F)c1.NCCN(CC1CCCCC1)S(=O)(=O)c1ccccn1>>N#Cc1ccc(NCCN(CC2CCCCC2)S(=O)(=O)c2ccccn2)c(F)c1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US20070191333A1,CCOC(=O)C1CCN(Cc2ccccc2)C1>>CCOC(=O)C1CCNC1,[Pd],CCO,,,,val
US20070281979A1,CS(C)=O.O=C(Nc1ncc(Br)s1)NS(=O)(=O)c1cccc(Cl)c1>>CSc1cnc(NC(=O)NS(=O)(=O)c2cccc(Cl)c2)s1,,CO,,,,val
US05403846,CS(=O)(=O)Nc1ccc2c(c1)C=CC1(CCC(N3CCc4ccccc4C3)CC1)O2>>CS(=O)(=O)Nc1ccc2c(c1)CCC1(CCC(N3CCc4ccccc4C3)CC1)O2,[Pd],CCO,,,,val
US20060142211A1,COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)cc3o2)cc1>>O=c1cc(-c2ccc(O)cc2)oc2cc(O)c(O)c(O)c12,,ClCCl,,BrB(Br)Br,,val
US20060211678A1,CC(C)(C)OC(=O)N1CC=C(c2cc3c(Cl)ncnc3[nH]2)CC1.Nc1ccn(CCc2ccccc2)n1>>CC(C)(C)OC(=O)N1CC=C(c2cc3c(Nc4ccn(CCc5ccccc5)n4)ncnc3[nH]2)CC1,,CCCCO,,,,val
US04772600,O=C(O)Cn1c(-c2ccc(Cl)cc2)nc2ccc(Cl)nc21.O=C(n1ccnc1)n1ccnc1>>NC(=O)Cn1c(-c2ccc(Cl)cc2)nc2ccc(Cl)nc21.O,,C1CCOC1,,,,val
US20130029973A1,CCN([C@@H]1CC[C@@H](C(=O)OC)CC1)S(=O)(=O)c1cccc(C(=O)Nc2sc3c(c2C(=O)Nc2ccc(CCCc4ccc(C(=O)OC)cc4)cc2)CCCC3)c1>>CCN([C@@H]1CC[C@@H](C(=O)O)CC1)S(=O)(=O)c1cccc(C(=O)Nc2sc3c(c2C(=O)Nc2ccc(CCCc4ccc(C(=O)O)cc4)cc2)CCCC3)c1,,C1CCOC1,,CO,[Na+].[OH-],val
US20100160392A1,CC(C)(C)OC(=O)CC(=O)OC(C)(C)C.CCOC(=O)CCCCCBr>>CCOC(=O)CCCCCC(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20160222028A1,COC(=O)c1ccc2c(c1)OCCN(C(=O)C1CCOCC1)[C@@H]2C(C)C.NO>>CC(C)[C@@H]1c2ccc(C(=O)NO)cc2OCCN1C(=O)C1CCOCC1,,C1CCOC1,CO,[Na+].[OH-],,val
US20040204386A1,CI.O=C(Nc1nc(Cl)cc(Cl)n1)C(F)(F)F>>CNc1nc(Cl)cc(Cl)n1,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US04666913,CC1NC(=O)Nc2ccccc21.O=C(Cl)CBr>>CC1NC(=O)Nc2ccc(C(=O)CBr)cc21,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05332731,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OC1CCOC1>>O=S(=O)(OC1CCOC1)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US04414390,COc1ccc(-c2cn3ccccc3n2)c2c1NC(=O)CC2.O=N[O-]>>COc1ccc(-c2nc3ccccn3c2N=O)c2c1NC(=O)CC2,,O,,Cl,,val
US20120095064A1,Cc1cc(C)[nH]n1.ClCc1cnc(Cl)s1>>Cc1cc(C)n(Cc2cnc(Cl)s2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20020120007A1,CCCc1ccc(C(=O)Nc2cc(O[Si](C)(C)C(C)(C)C)ccc2NC(=O)c2ccc(OC)cc2)cc1>>CCCc1ccc(C(=O)Nc2cc(O)ccc2NC(=O)c2ccc(OC)cc2)cc1,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20120088750A1,CCN=C=O.CCOC(=O)C1(C)CCN(c2ncc(-c3cc(-n4cccn4)n4nc(N)nc4c3)cn2)CC1>>CCNC(=O)Nc1nc2cc(-c3cnc(N4CCC(C)(C(=O)OCC)CC4)nc3)cc(-n3cccn3)n2n1,,C1COCCO1,,,,val
US20100004460A1,ClC(Cl)Cl.O=C(Cl)c1ccccc1.OCC(O)CO>>O=C(OCC1COCO1)c1ccccc1,,CCOC(C)=O,ClC(Cl)Cl,CCN(CC)CC,O,val
US06235771B1,CCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCS3(=O)=O)cc1>>CCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCS3(=O)=O)cc1,,COCCOC,,Cl,,val
US20080119518A1,COC=Cc1c(OC)cccc1N1CCOCC1>>COc1cccc(N2CCOCC2)c1CC=O,,C1CCOC1,Cl,CCOCC,O=C([O-])[O-].[K+].[K+],val
US20150274704A1,CC(C)(C)OC(=O)N1CCC2(CCC(N)CC2)C1.Clc1ccnc(Cl)n1>>CC(C)(C)OC(=O)N1CCC2(CCC(Nc3ccnc(Cl)n3)CC2)C1,,CCO,,CCN(CC)CC,,val
US20120226015A1,CCCCCCC(CCCCCC)(C(=O)OCC)C(=O)OCC>>CCCCCCC(CO)(CO)CCCCCC,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100168103A1,O=C(Cl)OCc1ccccc1.OC(c1ccccc1)C1CCNCC1>>O=C(OCc1ccccc1)N1CCC(C(O)c2ccccc2)CC1,,ClCCl,,,,val
US20130267499A1,C=CCN(Cc1ccn(C)n1)c1nn(Cc2ccc(OC)cc2)cc1C(=O)O.CCN(CC)CC.CN(C)C=O.O=C(Cl)C(=O)Cl>>C=CCN(Cc1ccn(C)n1)c1nn(Cc2ccc(OC)cc2)cc1C(=O)N(C)OC.C[NH2+]OC.[Cl-],,CN(C)C=O,,,,val
US06255305B1,CCOC(=O)C1CCC(C)CC1=O.O=S(=O)(Cl)C(F)(F)F>>CCOC(=O)C1=C(OS(=O)(=O)C(F)(F)F)CC(C)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150038510A1,CCc1ccccc1NC(C)=O.O=[N+]([O-])O>>CCc1cccc([N+](=O)[O-])c1NC(C)=O,,CC(=O)O,,,,val
US20160244429A1,Cc1ccc(S(=O)(=O)OCCCc2c[nH]c3ccc(C#N)cc23)cc1.NC(=O)COc1ccc2c(=O)n(-c3ccc(N4CCNCC4)c(F)c3)ccc2n1>>N#Cc1ccc2[nH]cc(CCCN3CCN(c4ccc(-n5ccc6nc(OCC(N)=O)ccc6c5=O)cc4F)CC3)c2c1,,CC#N,,[I-].[K+],,val
US20070249670A1,COC(=O)[C@H](COC1CCOCC1)NC(=O)OCc1ccccc1>>COC(=O)[C@@H](N)COC1CCOCC1,[Pd],CCO,,,,val
US20080107918A1,BrBr.c1ccc2cc(-c3c4ccccc4cc4ccccc34)ccc2c1>>Brc1c2ccccc2c(-c2ccc3ccccc3c2)c2ccccc12,,ClC(Cl)(Cl)Cl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20100099681A1,CC1(C)C(=O)N(Br)C(=O)N1Br.COC(=O)c1ccccc1Nc1cc(C)nn1-c1cc(F)ccc1F>>COC(=O)c1ccccc1Nc1c(Br)c(C)nn1-c1cc(F)ccc1F,,ClCCl,,,,val
US20080132525A1,CC1(C)O[C@@H]2[C@@H](CO[Si](C)(C)C(C)(C)C)O[C@@H](n3cnc4c(N)nc(I)nc43)[C@@H]2O1>>CC1(C)O[C@@H]2[C@@H](CO)O[C@@H](n3cnc4c(N)nc(I)nc43)[C@@H]2O1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050070630A1,C=C(C)C(=O)OCCN(CC)CC.COS(=O)(=O)c1ccc(C)cc1>>C=C(C)C(=O)OCC.CC[NH+](C)CC.Cc1ccc(S(=O)(=O)[O-])cc1,,Cc1ccccc1,,,,val
US20070078120A1,COC(=O)CC(O)CC(O)/C=C/C1(c2cccc(OC)c2)CCN(c2ccccc2OC)CC1>>COc1cccc(C2(/C=C/C(O)CC(O)CC(=O)O)CCN(c3ccccc3OC)CC2)c1,,CCO,,[Na+].[OH-],[Cl-].[NH4+],val
US20120309966A1,COC(=O)Cl.Cc1nccn2c(C3CCNCC3)nc(Br)c12>>COC(=O)N1CCC(c2nc(Br)c3c(C)nccn23)CC1,,ClCCl,,CCN(CC)CC,O,val
US20050026916A1,Fc1cccc(Cl)c1CCl.S=C1N[C@@H](c2ccccc2)[C@@H](c2ccccc2)N1>>Cl.Fc1cccc(Cl)c1CSC1=N[C@@H](c2ccccc2)[C@@H](c2ccccc2)N1,,CCO,,,,val
US20090306064A1,COCCCN1CCOc2ccc(COC3CN(S(=O)(=O)c4ccc(C)cc4)CC(O)C3c3ccc(Oc4ccc5c(c4)OCCN5C)cc3)cc21.Cc1ccc(S(=O)(=O)OCCN(C)S(=O)(=O)c2ccc(C)cc2)cc1>>CNCCOC1CNCC(OCc2ccc3c(c2)N(CCCOC)CCO3)C1c1ccc(Oc2ccc3c(c2)OCCN3C)cc1,,C1CCOC1,,[H-].[Na+],,val
US05624950,C=COC(=O)Cl.CC1(c2ccccc2)CCC(=O)C2CN(Cc3ccccc3)CC21>>C=COC(=O)N1CC2C(=O)CCC(C)(c3ccccc3)C2C1,,ClCCCl,,,,val
US20090137580A1,Nc1ccc(Oc2ncnc3ccn(CCOC(=O)c4ccccc4)c23)cc1Cl.O=C=Nc1cccc(C(F)(F)F)c1>>O=C(Nc1cccc(C(F)(F)F)c1)Nc1ccc(Oc2ncnc3ccn(CCO)c23)cc1Cl,,C1CCOC1,O,CCN(CC)CC,,val
US20110118245A1,COc1cc2c(Cl)ncnc2cc1OCCN1CCOCC1.Nc1cccc(O)c1>>COc1cc2c(Oc3cccc(N)c3)ncnc2cc1OCCN1CCOCC1,,CC(C)O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030186976A1,CCCCCCC(=O)CC(=O)OC.CI>>CCCCCCC(=O)C(C)C(=O)OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160115261A1,CCN(CC)C(=O)Cl.Oc1ccccc1-c1ccccc1O>>CCN(CC)C(=O)Oc1ccccc1-c1ccccc1O,Cl[Ti](Cl)(Cl)Cl,CCOCC,CS(C)=O,Cc1ccccc1,Cl,val
US05122523,CC(C)C[C@H]1C(C(O)CN2CCOCC2)OC(C)(C)N1C(=O)OCc1ccccc1>>CC(C)C[C@H](N)C(O)C(O)CN1CCOCC1,[Pd],CCO,,,,val
US20070287711A1,CC(O)c1cc(Br)cc(C(=O)O)c1O>>CCc1cc(Br)cc(C(=O)O)c1O,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US05641789,COc1ccc2c(c1)C(=O)C(Cc1cccc(N)c1)CC2.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc2c(c1)C(=O)C(Cc1cccc(NS(=O)(=O)C(F)(F)F)c1)CC2,,ClCCl,,CCN(CC)CC,,val
US20020052376A1,COC(=O)c1cc(C(OCCc2cncn2C)c2nccs2)ccc1CCc1ccc(F)cc1>>Cn1cncc1CCOC(c1ccc(CCc2ccc(F)cc2)c(C(=O)O)c1)c1nccs1,,CO,O,[Na+].[OH-],,val
US20140179698A1,COc1cc(N)cc(OC)c1.COc1ncccc1-c1cccc(-c2cnc(Cl)o2)c1>>COc1cc(Nc2ncc(-c3cccc(-c4ccc[nH]c4=O)c3)o2)cc(OC)c1,,CC(C)O,,Cl,,val
US20160185778A1,C=CC(C)(C)C(=O)Cl.CC(C)(C)OC(=O)N1CCC(=O)CC1>>C=CC(C)(C)C(=O)C1CN(C(=O)OC(C)(C)C)CCC1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US04364875,C=CCN.O=[N+]([O-])c1ccc(Oc2ccccc2)cc1Oc1ccccc1>>C=CCNc1cc(Oc2ccccc2)ccc1[N+](=O)[O-],,C1CCOC1,,,,val
US05719164,CCCCBr.O=[N+]([O-])c1ccc(O)cc1CO>>CCCCOc1ccc([N+](=O)[O-])c(CO)c1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20160166681A1,CI.O=[N+]([O-])c1ccc2ccccc2c1O>>COc1c([N+](=O)[O-])ccc2ccccc12,,CC(C)=O,,[K+].[OH-],,val
US20070191293A1,CC(C)(C)[Si](C)(C)Cl.OC[C@@H]1C[C@@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)[C@H](O)[C@@H]1O>>CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)[C@H](O)[C@@H]1O,,CN(C)C=O,,c1c[nH]cn1,,val
US20050059713A1,CCOC(=O)CBr.CS(=O)(=O)c1ccc(-c2ccc(O)c(CCNC(=O)c3cc4ccccc4cc3O)c2)cc1>>COC(=O)COc1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1CCNC(=O)c1cc2ccccc2cc1O,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110183979A1,CCOC(=O)C(=O)/C=C(\O)c1ccccn1.CNN>>CCOC(=O)c1cc(-c2ccccn2)n(C)n1,,CCO,,CO,ClCCl,val
US20070281936A1,CO.N#Cc1ncccc1CBr>>COCc1cccnc1C#N,,CO,,C[O-].[Na+],,val
US20130303507A1,CCOC1(O[Si](C)(C)C)CC1.COCCN[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1>>COCCN(C1CC1)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20140371199A1,Clc1ccc(-c2cnc3cnc(Br)cn23)cc1.NC(=O)c1ccc(B(O)O)cc1>>NC(=O)c1ccc(-c2cn3c(-c4ccc(Cl)cc4)cnc3cn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US20160159752A1,COc1ccc(S(=O)(=O)N2[C@@H](CCc3c(F)cncc3NC(=O)[C@@H](N)[C@@H](c3ccc(Cl)cc3)C3CCOCC3)CN(C(=O)OC(C)(C)C)C[C@@H]2C)cc1>>COc1ccc(S(=O)(=O)N2[C@@H](CCc3c(F)cncc3NC(=O)[C@@H](N)[C@@H](c3ccc(Cl)cc3)C3CCOCC3)CNC[C@@H]2C)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100137313A1,COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)cnc1OC.COc1cc(Nc2ncc(Br)c(-n3ccc(C(F)(F)F)n3)n2)cc(OC)c1>>COC(=O)c1cc(-c2cnc(Nc3cc(OC)cc(OC)c3)nc2-n2ccc(C(F)(F)F)n2)cnc1OC,,CC#N,O,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20110065708A1,CC(=O)c1ccc2ncc(Cc3ccc4c(cnn4C)c3)n2n1.NOCCO>>C/C(=N\OCCO)c1ccc2ncc(Cc3ccc4c(cnn4C)c3)n2n1,,C1CCOC1,,Cl,,val
US20110098276A1,NCC1CC1.NOC1CCN(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)CC1.O=C(n1ccnc1)n1ccnc1>>O=C(NCC1CC1)NOC1CCN(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20140045819A1,Clc1c(Br)cncc1Br.OB(O)C1CC1>>Clc1c(Br)cncc1C1CC1,,O,,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US20150250169A1,CC1(C)OC[C@@H]([C@H]2OC(=O)C(O)=C2OCc2ccccc2)O1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC2=C(OCc3ccccc3)[C@@H]([C@@H]3COC(C)(C)O3)OC2=O)cc1,,ClCCl,,CCN(CC)CC,O,val
US20110003795A1,COC(=O)C(C)c1ccc2ocnc2c1>>CC(C(=O)O)c1ccc2ocnc2c1,,C1CCOC1,O,CC(=O)O,[Li+].[OH-],val
US20060052403A1,CC(=O)OC(C)=O.Cc1ccc(Cn2c(O)nc3c(N)nc(NCCO)nc32)cn1>>CC(=O)OCCNc1nc(N)c2nc(O)n(Cc3ccc(C)nc3)c2n1,,c1ccncc1,,O=C([O-])O.[Na+],,val
US04937371,CCCc1c(OCCCCCC(=O)c2ccc3cc(OC)c(OC)cc3c2)ccc(C(=O)OC)c1O>>CCCc1c(OCCCCCC(=O)c2ccc3cc(OC)c(OC)cc3c2)ccc(C(=O)O)c1O,,C1COCCO1,CO,[Na+].[OH-],,val
US20160151375A1,COC(=O)C1CCC(Sc2cc(C(=O)O)ccc2F)C1.Nc1cc(F)c(F)c(F)c1>>COC(=O)C1CCC(Sc2cc(C(=O)Nc3cc(F)c(F)c(F)c3)ccc2F)C1,CN(C)c1ccncc1,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120093766A1,CC(C)(C)OC(=O)NCCCCCCCCNc1nc(Nc2ccc(C(=O)NCCCCl)cc2)nc(OCC(F)(F)F)n1>>NCCCCCCCCNc1nc(Nc2ccc(C(=O)NCCCCl)cc2)nc(OCC(F)(F)F)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140296069A1,CSc1cc(C)cc(C(=O)O)c1NC(=O)C(F)(F)F>>CSc1cc(C)cc(C(=O)O)c1N,,CO,O,Cl,[Li+].[OH-],val
US04769503,ClCl.Clc1ccc(C(Cl)(Cl)Cl)cc1>>Clc1ccc(C(Cl)(Cl)Cl)cc1Cl,,Cl,,,,val
US20070197512A1,C=CC(=O)OC.Cc1cc(Cl)c2c(c1)NC(=O)C(C(C)C)O2>>COC(=O)CCN1C(=O)C(C(C)C)Oc2c(Cl)cc(C)cc21,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20120077799A1,O=S1(=O)CCN2C=CC=C(Br)C2=N1.OB(O)c1ccc(-c2ccccc2)cc1>>O=S1(=O)CCN2C=CC=C(c3ccc(-c4ccccc4)cc3)C2=N1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US20090264445A1,CC#CC(=O)OCC.CC(C)Oc1ccc(F)c(O)c1F>>CCOC(=O)/C=C(\C)Oc1c(F)ccc(OC(C)C)c1F,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20050197362A1,CCN=C=O.COc1ccccc1CCN(CCCCC(=O)c1ccc2c(c1)CCN2)C(=O)OC(C)(C)C>>CCNC(=O)N1CCc2cc(C(=O)CCCCN(CCc3ccccc3OC)C(=O)OC(C)(C)C)ccc21,,C1CCOC1,,,,val
US20090076076A1,NNC(N)=S.O=C(CC[N+](=O)[O-])c1ccccc1>>NC(=S)NN=C(CC[N+](=O)[O-])c1ccccc1,,CC(=O)O,,CO,,val
US20140113935A1,CNCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)C1CC1>>CN(Cc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)C1CC1,,C1CCOC1,,CCN(CC)CC,Cl,val
US03984415,BrCc1ccccc1.O=c1[nH]c(=O)n(-c2cccc([N+](=O)[O-])c2)c2ncccc12>>O=c1c2cccnc2n(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US04316907,CC(=O)c1ccc(C(=O)O)s1.N>>CC(=O)c1ccc(C(N)=O)s1,,C1CCOC1,c1ccccc1,O=S(Cl)Cl,,val
US20160152605A1,CC(C)(C)OC(=O)N1CCC(NS(=O)C(C)(C)C)CC1c1ccccc1>>CC(C)(C)OC(=O)N1CCC(N)CC1c1ccccc1,,CO,Cl,,,val
US20130090340A1,CC(C)(C)OC(=O)N1CCn2c(C#N)c(-c3cccc(F)c3)c(C(N)=O)c2C1>>N#Cc1c(-c2cccc(F)c2)c(C(N)=O)c2n1CCNC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US06124281,CN(C)C=O.ClCCl.O=C(O)c1n[nH]c2c(=O)[nH]c3cc(Cl)ccc3c(=O)c12>>C=CCOC(=O)c1n[nH]c2c(=O)[nH]c3cc(Cl)ccc3c(=O)c12,CN(C)C=O,,,O=C(Cl)C(=O)Cl,,val
US20060223801A1,CCOC(=O)c1sc(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)nc1COC>>CCOC(=O)c1sc(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)nc1CO,,ClCCl,,BrB(Br)Br,,val
US20130345123A1,CC(C)(C)OC(=O)N[C@H]1CC=CCCN(Cc2ccccc2)C1=O>>N[C@H]1CC=CCCN(Cc2ccccc2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100137281A1,CCc1cc2c(=O)n(Cc3ccc(OC)cc3OC)c(=O)[nH]c2s1.Cc1ccc(C#N)c(-c2ccc(CO)cc2)c1>>CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4cc(C)ccc4C#N)cc3)c2s1,,C1CCOC1,CCOC(C)=O,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20030055250A1,Fc1c(Cl)cccc1CBr.NC(N)=S>>Fc1c(Cl)cccc1CS,,CCO,,,,val
US20110060011A1,CC(=O)C(NC(=O)c1ccc(NC(=O)c2ccccc2Cl)cc1)c1ccccc1>>Cc1oc(-c2ccc(NC(=O)c3ccccc3Cl)cc2)nc1-c1ccccc1,,c1ccncc1,,O=P(Cl)(Cl)Cl,O=C([O-])O.[Na+],val
US04280011,C=COCC(C)C.OCc1ccccc1>>CCCCOC(C)OCc1ccccc1,Cl,,,O=C([O-])[O-].[Na+].[Na+],,val
US05312939,CC(C)=CCC/C(C)=C\CO>>CC(C)=CCC[C@H](C)CCO,,c1ccccc1,,[H][H],,val
US20110152273A1,CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.CCn1cc(-c2nc(Cl)cc(C#N)c2C(=O)OC)cn1>>CCn1cc(-c2nc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)cc(C#N)c2C(=O)OC)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20080058547A1,C=C(CC(=O)OC)C(=O)O.COC(=O)C[C@@H](C)C(=O)O>>COC(=O)C(C)CC(=O)O,,CO,,[H][H],,val
US20060287303A1,CC(C)=O.Oc1ccc(Cl)cc1Br>>COc1ccc(Cl)cc1Br,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150344468A1,BrCCOC1CCCCO1.Oc1ccc(Br)nc1>>Brc1ccc(OCCOC2CCCCO2)cn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020028836A1,N#C[N-]C#N.Nc1cccc(C(F)(F)F)c1>>N#CN=C(N)Nc1cccc(C(F)(F)F)c1,,O,,Cl,,val
US20130142887A1,CN(C)C=O.Cc1cc(I)c(C(=O)O)cc1C>>Cc1cc(I)c(C(N)=O)cc1C,,O=S(Cl)Cl,,,,val
US20140051692A1,N#CCC(=O)c1cccc(Br)c1.NN>>Nc1cc(-c2cccc(Br)c2)n[nH]1,,CCO,,O,,val
US20140343032A1,C=CCCC(NC(=O)OC(C)(C)C)(C(=O)OCC)C(=O)OCC>>C=CCCC(N)(C(=O)OCC)C(=O)OCC,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110130282A1,CC(C)(C)c1nsc(Cl)c1C#N.Cc1cc(O)c(C)cc1N>>Cc1cc(Oc2snc(C(C)(C)C)c2C#N)c(C)cc1N,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05747498,C#Cc1cccc(Nc2ncnc3cc(Cl)c([N+](=O)[O-])cc23)c1.C[O-]>>C#Cc1cccc(Nc2ncnc3cc(OC)c([N+](=O)[O-])cc23)c1,,O,,Cl,,val
US04092482,C.O=C(CCC(Br)CC(Cl)(Cl)Cl)OCc1cccc(Oc2ccccc2)c1.c1ccccc1>>CC(C)(C=CC(Cl)(Cl)Cl)CC(=O)OCc1cccc(Oc2ccccc2)c1,,c1ccccc1,,C1CCNCC1,,val
US20110046133A1,Cc1ccc(NC(=O)c2ccc3nc(-c4c(C)cc(C#N)cc4C)[nH]c3c2)cc1C.[N-]=[N+]=[N-]>>Cc1ccc(NC(=O)c2ccc3nc(-c4c(C)cc(-c5nn[nH]n5)cc4C)[nH]c3c2)cc1C,,CN(C)C=O,,[Cl-].[NH4+],,val
US20090163508A1,Fc1ccc(-c2cc(N3CCNCC3)ncn2)c(F)c1.O=C(Nc1cccnn1)OCC(Cl)(Cl)Cl>>O=C(Nc1cccnn1)N1CCN(c2cc(-c3ccc(F)cc3F)ncn2)CC1,,C1CCOC1,CCCCCC,,,val
US20080096877A1,CC(C)(C)C(=O)Cl.COC(OC)C(CNC(=O)c1cc2cc(O)cc([N+](=O)[O-])c2[nH]1)SCc1ccccc1>>COC(OC)C(CNC(=O)c1cc2cc(OC(=O)C(C)(C)C)cc([N+](=O)[O-])c2[nH]1)SCc1ccccc1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US05212195,CCCCc1cc(C=CC(=O)OC)c[nH]1.N#Cc1ccccc1-c1ccc(CBr)cc1>>CCCCc1cc(C=CC(=O)OC)cn1Cc1ccc(-c2ccccc2C#N)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20050080106A1,N#Cc1ccc(NC(=O)c2cc(OCc3ccccc3)cc(OCc3ccccc3)c2)nc1.NO>>N=C(NO)c1ccc(NC(=O)c2cc(OCc3ccccc3)cc(OCc3ccccc3)c2)nc1,,CCO,,CCN(CC)CC,Cl,val
US06627651B1,CCOc1ccc(CO)cc1OCC.O=S(Cl)Cl>>CCOc1ccc(CCl)cc1OCC,c1ccncc1,CCOC(C)=O,Cc1ccccc1,,,val
US20140020808A1,CO.Nc1ccc(N)cc1.O=C1C=CC(=O)O1>>CO.Nc1ccc(NC(=O)/C=C\C(=O)O)cc1,,C1CCOC1,,,,val
US05206375,CN(C)C=Nc1sc(C#N)c(Cl)c1C#N>>N#Cc1sc(N)c(C#N)c1Cl,,CCO,,Cl,,val
US20120270882A1,Cc1cc(=O)c(OCc2ccccc2)cn1CC(F)(F)F.Cl>>Cc1cc(=O)c(O)cn1CC(F)(F)F.Cl,,CC(C)O,,,,val
US04229464,CCOC(=O)c1cc2c(OCc3ccccc3)cc(C)cc2[nH]1>>CCOC(=O)c1cc2c(O)cc(C)cc2[nH]1,[Pd],CCO,CO,,,val
US20090291967A1,CC(C)(C)c1ccc(C(=O)NN)cc1.COC(OC)N(C)C.NCc1ccc(F)cc1>>CC(C)(C)c1ccc(-c2nncn2Cc2ccc(F)cc2)cc1,,CC#N,,CC(=O)O,,val
US20090131457A1,CNC.O=C(O)c1cc(Br)cc(F)c1OCc1ccccc1>>CN(C)C(=O)c1cc(Br)cc(F)c1OCc1ccccc1,,C1CCOC1,Cl,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150141413A1,COc1ccc(CN2[C@](C)(c3cc(Br)ccc3F)COS2(=O)=O)c(OC)c1.N#CCS>>COc1ccc(CN[C@@](C)(CSCC#N)c2cc(Br)ccc2F)c(OC)c1,,CN(C)C=O,,CN(C)C(=N)N(C)C,,val
US20080312226A1,CC(C)(C)OC(=O)N1CCNCC1.Clc1nc(-c2ccoc2)ns1>>CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccoc3)ns2)CC1,,CN(C)C=O,,CCN(CC)CC,O,val
US20040029902A1,ClCc1nc(-c2ccccc2)no1.O=[N+]([O-])c1ccc(O)cc1>>O=[N+]([O-])c1ccc(OCc2nc(-c3ccccc3)no2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160068559A1,CC[C@@H](CCN(C)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21)NC(=O)Nc1ccc(C(C)(C)C)cc1>>CC[C@@H](CCN(C)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)NC(=O)Nc1ccc(C(C)(C)C)cc1,,CO,Cl,,,val
US20140371203A1,CNC1CCN(C)C1.O=CC1CCN(c2nc(Cl)nc3scc(-c4ccccc4)c23)CC1>>CN1CCC(N(C)CC2CCN(c3nc(Cl)nc4scc(-c5ccccc5)c34)CC2)C1,,ClCCl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20110178063A1,CC(C)n1nccc1C(=O)Nc1cc(B2OC(C)(C)CC(C)(C)O2)cc2nn(C3CCCCO3)cc12.Clc1nc[nH]c2nccc1-2>>CC(C)n1nccc1C(=O)Nc1cc(-c2ncnc3[nH]ccc23)cc2[nH]ncc12,,C1COCCO1,CO,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US04470972,CCOC(=O)[C@@H]1CC(=O)CN1C(=O)OCc1ccccc1.SCCS>>CCOC(=O)[C@@H]1CC2(CN1C(=O)OCc1ccccc1)SCCS2,,CCO,,,,val
US05972953,CN(C(=O)C=Cc1cccc([N+](=O)[O-])c1)[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5>>CN(C(=O)C=Cc1cccc(N)c1)[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5,,CCO,,[Na+].[OH-],,val
US20040106626A1,COC(=O)c1cc(C(=O)[O-])cc([N+](=O)[O-])c1>>COC(=O)c1cc(CO)cc([N+](=O)[O-])c1,,C1CCOC1,,B,,val
US20150266881A1,CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1cccc(C(=O)O)c1.Cc1nnc(N)s1>>Cc1nnc(NC(=O)c2cccc([C@@H]3C[C@H]3NC(=O)OC(C)(C)C)c2)s1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130281433A1,COC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccc4c(c3)c(-c3cccnc3C)nn4C)sc2c1-c1ccc(Cl)cc1>>Cc1cc2nc(-c3ccc4c(c3)c(-c3ccncc3)nn4C)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O,,C1CCOC1,,CCO,[Na+].[OH-],val
US07943669B2,CCOC(=O)COc1ccc(SCc2cc(C#CCN3CCOCC3)cc(OCC3CC3)c2)cc1C>>Cc1cc(SCc2cc(C#CCN3CCOCC3)cc(OCC3CC3)c2)ccc1OCC(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20100136491A1,C/C=C/C(=O)Cl.CC(=O)c1ccc(-n2c3ccccc3c3ccccc32)cc1.O=C(Cl)c1cccs1>>C/C=C/C(=O)c1ccc2c(c1)c1cc(C(=O)c3cccs3)ccc1n2-c1ccc(C(C)=O)cc1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20040082639A1,COc1cc2c(cc1OC)C(=O)C(C(=S)n1ccnc1)C2.Nc1cccc(CO)c1>>COc1cc2c(cc1OC)C(=O)C(C(=S)Nc1cccc(CO)c1)C2,,C1CCOC1,,,,val
US20060122239A1,CNc1ccc(Br)cc1C.COc1ccc(CCl)cc1>>COc1ccc(CN(C)c2ccc(Br)cc2C)cc1,,CN(C)C=O,,[H-].[Na+],,val
US06548495B2,COC(=O)c1coc(-c2cccc(C3=Nc4ccc(-n5cccc5)cc4NC(=O)C3)c2)n1>>O=C1CC(c2cccc(-c3nc(CO)co3)c2)=Nc2ccc(-n3cccc3)cc2N1,,C1CCOC1,,CO,[BH4-].[Li+],val
US20120028800A1,CCc1cc(Br)ccc1I.O=Cc1ccco1>>CCc1cc(Br)ccc1C(O)c1ccco1,,C1CCOC1,,II,[Mg],val
US20130053409A1,COc1cc(N2CC[C@@H](N(C)C)C2)c([N+](=O)[O-])cc1Nc1nccc(-c2cnn3ccccc23)n1>>COc1cc(N2CC[C@@H](N(C)C)C2)c(N)cc1Nc1nccc(-c2cnn3ccccc23)n1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20020010181A1,Clc1ncc(Cc2ccncc2)c2ccccc12.NCc1cccc(Cl)c1>>Clc1cccc(CNc2ncc(Cc3ccncc3)c3ccccc23)c1,,CCOC(C)=O,,N,,val
US20020161006A1,COC(=O)CC1=C(C(=O)OC)C(c2c(Cl)cccc2Cl)C(C(=O)OC)=C(CCc2ccccc2N)N1.CS(=O)(=O)Cl>>COC(=O)CC1=C(C(=O)OC)C(c2c(Cl)cccc2Cl)C(C(=O)OC)=C(CCc2ccccc2NS(C)(=O)=O)N1,,ClCCl,,CCN(CC)CC,,val
US20070185155A1,OC(c1ccccc1)(c1ccccc1)C12CCN(CC1)CC2.OCCBr>>OCC[N+]12CCC(C(O)(c3ccccc3)c3ccccc3)(CC1)CC2.[Br-],,CC#N,,,,val
US20060142357A1,CCN(C(C)C)C(C)C.O=C(O)C1(Br)CCCC1>>CCOC(=O)C1(Br)CCCC1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20100249229A1,CCCC1=C[C@H]2[C@@H](C1)C[C@]2(CC(=O)OC(C)(C)C)C[N+](=O)[O-]>>CCCC1=C[C@H]2[C@@H](C1)C[C@@]2(CN)CC(=O)O,[Fe],CCO,O,[Cl-].[NH4+],,val
US20150087585A1,COC(=O)[C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1>>O=C(O)[C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1,,CCO,,[Na+].[OH-],,val
US20140094459A1,O=[N+]([O-])c1ccc(Oc2cc(F)ccc2F)cc1>>Nc1ccc(Oc2cc(F)ccc2F)cc1,[Ni],CO,,NN,O,val
US20060084643A1,Cc1cc2c(s1)Nc1ccccc1NC2=O.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>Cc1cc2c(s1)Nc1ccccc1NC2=S,,c1ccncc1,,CCO,O,val
US06599917B1,COc1ccc(Cc2nc(C)ccc2O)cc1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc(Cc2nc(C)ccc2OS(=O)(=O)C(F)(F)F)cc1,CN(C)c1ccncc1,O,,CCN(CC)CC,ClCCl,val
US20130178486A1,CC(=NO)c1nc2ccn(S(=O)(=O)c3ccc(C)cc3)c2cc1Cl>>Cc1ccc(S(=O)(=O)n2ccc3nc(C(C)N)c(Cl)cc32)cc1,[Zn],CC(=O)O,CO,[Cl-].[NH4+],,val
US20090298836A1,CC(C)=O.N[C@H](CNc1nnc(-c2ccc3c(c2)CC(=O)N3)s1)Cc1ccc(C(F)(F)F)cc1>>CC(C)=C1C(=O)Nc2ccc(-c3nnc(NC[C@@H](N)Cc4ccc(C(F)(F)F)cc4)s3)cc21,,CO,,N,,val
US20060211697A1,C#CC(=O)OC.Cc1ccc(Oc2ccccc2N=[N+]=[N-])c(O)c1>>COC(=O)c1cn(-c2ccccc2Oc2ccc(C)cc2O)nn1,,Cc1ccccc1,,,,val
US20060022584A1,CC1=CC(=C(C#N)C#N)C=C(C(C)C)O1.O=Cc1ccc(N2N=C(c3ccccc3)CC2c2ccccc2)cc1>>CC(C)C1=CC(=C(C#N)C#N)C=C(C=Cc2ccc(N3N=C(c4ccccc4)CC3c3ccccc3)cc2)O1,,CCO,,C1CCNCC1,,val
US20080306055A1,COc1cc(Cl)ccc1CO.Cl>>COc1cc(Cl)ccc1CCl,,ClCCl,,CS(=O)(=O)Cl,,val
US20120264735A1,CCOC(=O)CN1CCC(F)(F)C1>>OCCN1CCC(F)(F)C1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20150191461A1,CCOC(=O)CC(=O)CCl.Ic1cn[nH]c1>>CCOC(=O)CC(=O)Cn1cc(I)cn1,,C1CCOC1,O,[H-].[Na+],,val
US20060276433A1,CC(=O)Nc1ccc(C=NNc2ccc(-c3cnco3)cc2)cc1>>Nc1ccc(C=NNc2ccc(-c3cnco3)cc2)cc1,,CCO,Cl,O=C([O-])O.[Na+],,val
US20110028479A1,COc1ccc(-c2c(-c3ccccc3)c[nH]c2C#N)cc1.Cc1cc(C)c(S(=O)(=O)NO)c(C)c1>>COc1ccc(-c2c(-c3ccccc3)cn(N)c2C#N)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US03985888,CCOS(=O)(=O)OCC.O=C1CCC2(CCC(=O)c3ccccc32)C(=O)N1>>CCN1C(=O)CCC2(CCC(=O)c3ccccc32)C1=O,,CN(C)C=O,,Cl,[H-].[Na+],val
US20150225422A1,CI.Nc1ncc(Br)cc1C(=O)NC12CC(C1)C2>>CN(C(=O)c1cc(Br)cnc1N)C12CC(C1)C2,,C1CCOC1,,CC(C)(C)O[K],,val
US20150038509A1,Cn1c(C=O)nc2ccccc21.O=C1c2ccccc2C(=O)N1CCCCNC1CCCc2cccnc21>>Cn1c(CN(CCCCN2C(=O)c3ccccc3C2=O)C2CCCc3cccnc32)nc2ccccc21,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090305892A1,COC(=O)CC(=O)OC.COC(=O)c1nccnc1N>>COC(=O)c1c(O)nc2nccnc2c1O,,CO,,C[O-].[Na+],,val
US20050267095A1,NCC1(c2ccc(OCCCN3CCCC3)cc2)CCOCC1.O=S(=O)(Cl)c1ccccc1F>>O=S(=O)(NCC1(c2ccc(OCCCN3CCCC3)cc2)CCOCC1)c1ccccc1F,,ClCCl,,CCN(CC)CC,,val
US20130102776A1,O=C1CCc2cc(O)ccc21.O=Cc1c[nH]c2ccccc12>>O=C1/C(=C/c2c[nH]c3ccccc23)Cc2cc(O)ccc21,,CO,,O,[Na+].[OH-],val
US20090093524A1,Cc1cc(O[Si](C)(C)C(C)(C)C)ccc1N(C)C(=O)OCc1ccccc1>>CNc1ccc(O[Si](C)(C)C(C)(C)C)cc1C,[Pd],CO,,,,val
US20060069110A1,CC(=O)OC(C)=O.CN(c1ccnc(NC2CCNCC2)n1)c1ccnc(-c2ccccc2)n1>>CC(=O)N1CCC(Nc2nccc(N(C)c3ccnc(-c4ccccc4)n3)n2)CC1,,ClCCl,,CCN(CC)CC,,val
US20110306607A1,COc1cc(C(=O)N2CCC3(CC2)Oc2cc(Cl)ccc2-n2c(C=O)ccc23)ccc1C(F)(F)F>>COc1cc(C(=O)N2CCC3(CC2)Oc2cc(Cl)ccc2-n2c(CO)ccc23)ccc1C(F)(F)F,,C1CCOC1,,[BH4-].[Na+],,val
US05389633,CCC(CC)(CO)CS(=O)(=O)N=CN(C)C.Cc1cc2ncnn2nc1Cl>>CCC(CC)(COc1nn2ncnc2cc1C)CS(N)(=O)=O,,C1CCOC1,,Cl,[H-].[Na+],val
US20120208874A1,C#CCBr.COc1ccc(O)cc1OC>>C#CCOc1ccc(OC)c(OC)c1,,Cc1ccccc1,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20100286209A1,C1=COCCC1.CC(C)(C)[Si](C)(C)Oc1ccc2[nH]nc(I)c2c1>>CC(C)(C)[Si](C)(C)Oc1ccc2c(c1)c(I)nn2C1CCCCO1,,C1CCOC1,ClCCl,CS(=O)(=O)O,,val
US20080207654A1,CCCCc1nc(C)c(CC(=O)C(C)(C)C)c(=O)[nH]1.N#Cc1ccccc1-c1ccc(CBr)cc1>>CCCCc1nc(C)c(CC(=O)C(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20070082907A1,CCc1cc(Oc2cccc(C#N)c2)ccc1CCC(=O)OC>>CCc1cc(Oc2cccc(CN)c2)ccc1CCC(=O)OC,[Pd],CC(=O)O,,[H][H],,val
US20060094588A1,COc1ccc(CN)c(OC)c1.Cn1c(C=O)nc2c(-c3ccccc3)ccc(-c3ccccc3)c21>>COc1ccc(C/N=C/c2nc3c(-c4ccccc4)ccc(-c4ccccc4)c3n2C)c(OC)c1,CC(=O)O,CO,,,,val
US20060063787A1,CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2nc(Cl)n(Cc3ccccc3C#N)c(=O)c21.CNC>>CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2nc(N(C)C)n(Cc3ccccc3C#N)c(=O)c21,,CN(C)C=O,,,,val
US20010034343A1,COc1ccc(OC(F)(F)F)cc1C(=O)O.O=C(Cl)C(=O)Cl>>COc1ccc(OC(F)(F)F)cc1C(=O)Cl,CN(C)C=O,ClCCl,,,,val
US20080293712A1,O=P(Cl)(Cl)Cl.Oc1nccc2c1cnc1ccc(Br)cc12>>Clc1nccc2c1cnc1ccc(Br)cc12,,CN(C)C=O,,,,val
USH0001209,CI.CN(C)c1ccc(C(=O)C2CC2)cc1>>C[N+](C)(C)c1ccc(C(=O)C2CC2)cc1.[I-],,CCOC(C)=O,,CN(C)C=O,,val
US20080096877A1,CCOCC.COC(=O)CN1CCC2(CC1)CN=C(c1cc3cccc(N(C)S(=O)(=O)c4cccs4)c3[nH]1)S2.[Li]C>>CN(c1cccc2cc(C3=NCC4(CCN(CC(C)(C)O)CC4)S3)[nH]c12)S(=O)(=O)c1cccs1,,C1CCOC1,,[Cl-].[NH4+],,val
US04569690,BrCCBr.CCSC(=S)c1cccc(Cl)c1.NO>>Clc1cccc(C2=NOCCS2)c1,,CCO,O,CCN(CC)CC,Cl,val
US07442808B2,CC(C)(C)[Si](C)(C)Oc1ccc2c(c1)OCC2=O>>CC(C)(C)[Si](C)(C)Oc1ccc2c(c1)OCC2O,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US06376490B1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.COc1nc2cc(Cl)c(Cl)c(NC(C)=O)c2nc1OC>>COc1nc2cc(Cl)c(Cl)c(NC(C)=S)c2nc1OC,,Cc1ccccc1,,,,val
US20030008768A1,Cc1ccccc1B(O)O.Clc1cccc(Cl)c1Br>>Cc1ccccc1-c1c(Cl)cccc1Cl,,Cc1ccccc1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US04739106,CCOC(=O)C#CC(C)(C)O.O=C=NS(=O)(=O)Cl>>CCOC(=O)C#CC(C)(C)OC(N)=O,,O,,ClCCl,,val
US20020037924A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)OCCCc1cccnc1>>O=C(OCCCc1cccnc1)C1CCCN1,,ClCCl,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],,val
US06326386B1,CC(C)(C)OC(=O)N(CCOc1cc(Cl)cc(C(=O)O)c1)c1ccncc1.CC(C)NCCS(N)(=O)=O>>CC(C)N(CCS(N)(=O)=O)C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060128712A1,CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O.COc1cccc2sc(N3CCNCC3)nc12>>COc1cccc2sc(N3CCN(C(=O)c4cc(S(C)(=O)=O)ccc4OC(C)C)CC3)nc12,,C1CCOC1,,Cl,,val
US20050209165A1,CO[C@H]1O[C@H](COc2cccc(-c3ccc([C@@H]4[C@@H](CC[C@H](O)c5ccc(F)cc5)C(=O)N4c4ccc(F)cc4)cc3)c2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1>>CO[C@H]1O[C@H](COc2cccc(-c3ccc([C@@H]4[C@@H](CC[C@H](O)c5ccc(F)cc5)C(=O)N4c4ccc(F)cc4)cc3)c2)[C@@H](O)[C@H](O)[C@H]1O,[Pd],CCO,,,,val
US20100113820A1,BrC(Br)(Br)Br.CCOCc1cc(OC)c(-c2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)OCC)cc2)c(OC)c1>>CCOC(=O)[C@H](Cc1ccc(-c2c(OC)cc(CBr)cc2OC)cc1)NC(=O)c1c(Cl)cccc1Cl,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04362728,N.O=C1c2ccccc2C(=O)N1CCCSc1nccc(NC(=S)NCC(F)(F)F)n1>>NCCCSc1nccc(NC(N)=NCC(F)(F)F)n1,,CN(C)C=O,,,,val
US20100137349A1,CC1(C)NC(=O)NC1=O.C[N+](C)(C)CCBr>>CC1(C)NC(=O)N(CC[N+](C)(C)C)C1=O.[Br-],,CN(C)C=O,,[H-].[Na+],,val
US20120202781A1,CC(C)S(=O)(=O)N[C@@H]1Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2C1.O>>CC(C)S(=O)(=O)N[C@@H]1Cc2ccc(O)cc2C1,,O,,CC(C)=O,,val
US20050107345A1,CCCCCCCCCCCCC(CCP(=O)(OCC)OCC)NC(=O)OCc1ccccc1>>CCCCCCCCCCCCC(N)CCP(=O)(O)O,,ClCCl,,C[Si](C)(C)I,,val
US20120094982A1,COc1ccc(CN2C(=O)C(CCc3ccccc3Cl)N=C(c3cnc4[nH]c(=O)[nH]c4c3)c3cc(Cl)ccc32)cc1>>O=C1Nc2ccc(Cl)cc2C(c2cnc3[nH]c(=O)[nH]c3c2)=NC1CCc1ccccc1Cl,,COc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20150126485A1,CC1(C)OB(c2ccnn2C2CCCCO2)OC1(C)C.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1ccc(N2C[C@H](O)[C@@H](O)C2)c(Br)c1>>O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1ccc(N2C[C@H](O)[C@@H](O)C2)c(-c2ccn[nH]2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,COCCOC,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20100120858A1,CC(C)(C)OC(=O)N1CCC[C@H](CO)C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCC[C@H](CS(C)(=O)=O)C1,,ClCCl,,CCN(CC)CC,,val
US20080280875A1,CC1(C)Cc2c(Oc3cnc(C(=O)N4CC(F)C4)c(F)c3)cc(C(=O)O)cc2O1.Cn1ccc(N)n1>>Cn1ccc(NC(=O)c2cc(Oc3cnc(C(=O)N4CC(F)C4)c(F)c3)c3c(c2)OC(C)(C)C3)n1,,ClCCCl,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100081652A1,COC(=O)CS(=O)Cc1ccc(C=CC(=O)c2c(O)cc(C)n(C)c2=O)s1>>Cc1cc(O)c(C(=O)C=Cc2ccc(CS(=O)CC(=O)O)s2)c(=O)n1C,,CO,,[Na+].[OH-],,val
US20140275076A1,COC(=O)c1ccc2c(c1)CC(=O)N2.NN>>NNC(=O)c1ccc2c(c1)CC(=O)N2,,CCO,,O,,val
US20110110889A1,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3c(c2)cc(C)n3S(=O)(=O)c2ccccc2)c1F>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(C)cc3c2)c1F,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20140094459A1,N#CCC(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)ncnc21.O=CC1CC1>>N#CC(=CC1CC1)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)ncnc21,,CO,,C1CCNCC1,,val
US20030149016A1,N.O=S(=O)(Cl)c1ncn2ccsc12>>NS(=O)(=O)c1ncn2ccsc12,,C1CCOC1,,CO,,val
US20150011548A1,C1COCCN1.CCOC(=O)CCl>>CCOC(=O)CN1CCOCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130165423A1,CC(C)(C)[S@](=O)N=Cc1ccc(Cl)cc1C(F)(F)F.C[Mg]Br>>C[C@@H](N)c1ccc(Cl)cc1C(F)(F)F,,ClCCl,,,,val
US20160168156A1,COc1ncc(F)cc1C1=NCCC1>>COc1ncc(F)cc1C1CCCN1,,CO,O,[BH4-].[Na+],,val
US04265890,COc1cc2c(c(Sc3ccccc3)c1OC)CCNCC2.O=C(Cl)C1CC1>>COc1cc2c(c(Sc3ccccc3)c1OC)CCN(C(=O)C1CC1)CC2,,CCN(CC)CC,,ClCCl,,val
US20120302578A1,CC(C)(C)OC(=O)n1c(-c2cnco2)cc2ccccc21.ClC(Cl)(Cl)C(Cl)(Cl)Cl>>CC(C)(C)OC(=O)n1c(-c2cnc(Cl)o2)cc2ccccc21,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20060160865A1,CN(C(=O)Oc1ccc(N)cn1)c1ccccc1.COc1ccccc1C(=O)Cl>>COc1ccccc1C(=O)Nc1ccc(OC(=O)N(C)c2ccccc2)nc1,,CC#N,,CCN(CC)CC,ClCCl,val
US20100160424A1,COC(=O)Cl.COC(=O)c1cccc(C(OCCN)c2ccccc2)c1>>COC(=O)NCCOC(c1ccccc1)c1cccc(C(=O)OC)c1,,C1CCOC1,ClCCl,CCN(CC)CC,O,val
US05120759,CC(C)[C@@H](C(=O)O)c1ccc(F)cc1.O=C(Cl)C(=O)Cl>>CC(C)[C@@H](C(=O)Cl)c1ccc(F)cc1,,ClCCl,,,,val
US20060035963A1,CC(=O)Oc1c2c(c3ccccc3c1OC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)OC(C)(C)CC2.Cl>>CC(=O)Oc1c2c(c3ccccc3c1OC(=O)[C@@H]1CCCN1)OC(C)(C)CC2.Cl,,C1COCCO1,,,,val
US05854268,CC(C)(C)OC(=O)N1CC[C@@H](CSCc2ccc(F)cc2)C1>>Fc1ccc(CSC[C@@H]2CCNC2)cc1,,O=CO,,,,val
US20100295030A1,COc1cccc(-c2ccccc2-c2ccccc2)c1>>COc1ccc2c3ccccc3c3ccccc3c2c1,Cl[Fe](Cl)Cl,ClCCl,,,,val
US20110039889A1,CC(C)Oc1ccc(-c2nc(-c3cccc4c(Cl)nccc34)no2)cc1Cl.O=C(O)[C@@H]1CCCN1>>CC(C)Oc1ccc(-c2nc(-c3cccc4c(N5CCC[C@H]5C(=O)O)nccc34)no2)cc1Cl,,ClCCl,,CS(C)=O,[H-].[Na+],val
US20080200473A1,Cc1ccc(C(=O)CBr)cc1.Cc1ccc(N)nc1>>Cc1ccc(-c2c[n+]3cc(C)ccc3[nH]2)cc1.[Br-],,CCO,,CC(C)=O,,val
US20130045980A1,Cc1ccncc1-c1cc(Cl)nn2c(Br)cnc12.OB(O)c1ccccc1>>Cc1ccncc1-c1cc(Cl)nn2c(-c3ccccc3)cnc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20110311461A1,CC(=O)c1sccc1NC(C(=O)O)c1ccccc1.O[C@H]1CN2CCC1CC2>>CC(=O)c1sccc1NC(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20080004275A1,COCCn1cc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)nc1C(=O)O.NCc1cccnc1>>COCCn1cc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)nc1C(=O)NCc1cccnc1,,CN(C)C=O,,O,O=C(n1ccnc1)n1ccnc1,val
US20090326009A1,COc1ccccc1-c1ccc2c(c1CCl)C(C)=CC(C)(C)N2.OCc1ccccc1>>COc1ccccc1-c1ccc2c(c1COCc1ccccc1)C(C)=CC(C)(C)N2,,C1CCOC1,,CCOC(C)=O,[H-].[Na+],val
US20150065477A1,CC(C)(C)OC(=O)N1CCc2cn(-c3ncccc3C(=O)NC(Cc3ccccc3)C(O)C(N)=O)nc2C1>>CC(C)(C)OC(=O)N1CCc2cn(-c3ncccc3C(=O)NC(Cc3ccccc3)C(=O)C(N)=O)nc2C1,,CC#N,O,,,val
US05594023,COc1cc([N+](=O)[O-])ccc1S(=O)(=O)N1C(=O)C(N)(c2ccccc2Cl)c2cc(Cl)ccc21>>COc1cc(N)ccc1S(=O)(=O)N1C(=O)C(N)(c2ccccc2Cl)c2cc(Cl)ccc21,[Ni],C1CCOC1,CO,[H][H],,val
US20030092677A1,CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccccc2)cc1NC(=O)CC(=O)c1ccnc(C#N)c1>>N#Cc1cc(C2=Nc3ccc(C#Cc4ccccc4)cc3NC(=O)C2)ccn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04115385,CC1(C)S[C@@H]2C(N)C(=O)N2C1c1nnn[nH]1.NCCOc1ccccc1CC(=O)O>>CC1(C)S[C@@H]2C(NC(=O)Cc3ccccc3OCCN)C(=O)N2C1c1nnn[nH]1,,CCN(CC)CC,,[Br-].[K+],,val
US20090069341A1,CC(=O)c1ccc(F)c([N+](=O)[O-])c1.CCc1cc(N)c(OC)cc1OC>>CCc1cc(Nc2ccc(C(C)=O)cc2[N+](=O)[O-])c(OC)cc1OC,,CN(C)C=O,,CCN(CC)CC,,val
US05866583,O=C(O)[C@@H](O)[C@H](O)C(=O)O.c1ccc(C2NCCc3ccccc32)nc1>>O=C(O)[C@@H](O)[C@H](O)C(=O)O.c1ccc([C@@H]2NCCc3ccccc32)nc1,,CCO,,,,val
US04053615,CC(=O)O.CCN1CCC(N2C(=O)c3ccc([N+](=O)[O-])cc3C2=O)CC1.Cl>>CCN1CCC(N2C(=O)c3ccc(N)cc3C2=O)CC1.Cl.O,[Pd],CC(=O)O,,CCO,[H][H],val
US06274587B1,Nc1cc[nH]n1.O=C1CSCC(=O)C1.O=Cc1ccc(F)c(Br)c1>>O=C1CSCC2=C1C(c1ccc(F)c(Br)c1)n1nccc1N2,,CCO,,,,val
US20110144105A1,COc1cnc2[nH]c(C(=CC3CCOCC3)c3ccc(S(C)(=O)=O)cc3)cc2c1>>COc1cnc2[nH]c(C(CC3CCOCC3)c3ccc(S(C)(=O)=O)cc3)cc2c1,[Pd],CO,,,,val
US20080132522A1,CC(C)Oc1nc(S(C)(=O)=O)nc(Cl)c1-c1c(F)cc(F)cc1F.c1cn[nH]c1>>CC(C)Oc1nc(-n2cccn2)nc(Cl)c1-c1c(F)cc(F)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US20150344471A1,CN(C(=O)c1ccc(C#N)cn1)c1ccn2nccc2c1.O=C1CCC(=O)N1Br>>CN(C(=O)c1ccc(C#N)cn1)c1ccn2ncc(Br)c2c1,,CCOC(C)=O,,,,val
US20040087798A1,COc1ccncc1I.O=[N+]([O-])c1cccc(B(O)O)c1>>COc1ccncc1-c1cccc([N+](=O)[O-])c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20040147608A1,CCOC(=O)C1(C#N)CC1CC(C)C>>CCOC(=O)C1(CN)CC1CC(C)C,[Ni],CCO,,CCN(CC)CC,,val
US20110015157A1,CCOC(=O)COc1cccc([C@H](C)N2CCC(C)(c3ccccc3)OC2=O)c1>>C[C@@H](c1cccc(OCC(=O)O)c1)N1CCC(C)(c2ccccc2)OC1=O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US05968982,CO.O=C(O)C(Cl)(Cl)CCCCCCCCCCCCc1ccccc1>>COC(=O)C(Cl)(Cl)CCCCCCCCCCCCc1ccccc1,,CO,,O=C(Cl)C(=O)Cl,,val
US20080312226A1,Nc1ccccn1.O=C(Cl)OCC(Cl)(Cl)Cl>>O=C(Nc1ccccn1)OCC(Cl)(Cl)Cl,,C1CCOC1,,O,c1ccncc1,val
US20120283434A1,Nc1ccc(N2CCOCC2=O)cc1.O=C(Cl)OCc1ccccc1>>O=C(Nc1ccc(N2CCOCC2=O)cc1)OCc1ccccc1,,CC(C)=O,,O,O=C([O-])O.[Na+],val
US20140275548A1,CC(C)(C(=O)O)c1cnc2cc(OCc3cccc(Cl)c3)ccc2c1.O=C(Cl)C(=O)Cl>>CC(C)(C(=O)Cl)c1cnc2cc(OCc3cccc(Cl)c3)ccc2c1,CN(C)C=O,ClCCl,,,,val
US20010034357A1,Cc1cc(OC[C@@H](C)N(C)C)cnc1Cl.Cc1ccc(S(=O)(=O)O)cc1>>Cc1cc(OC[C@@H](C)N(C)C)cnc1Cl.Cc1ccc(S(=O)(=O)O)cc1,,CCOC(C)=O,,CCOCC,O,val
US20050096337A1,O=C(Cl)C(=O)Cl.O=C(O)c1cnc(-c2ccc(OC(F)(F)F)cc2)nc1C(F)(F)F>>O=C(Cl)c1cnc(-c2ccc(OC(F)(F)F)cc2)nc1C(F)(F)F,CN(C)C=O,ClCCl,,,,val
US20100267676A1,O=C1C[C@H](c2ccc(Cl)c(Br)c2)CN1.[OH-]>>NC[C@H](CC(=O)O)c1ccc(Cl)c(Br)c1,,CC#N,,Cl,,val
US20130150376A1,CC(C)(C)[Si](C)(C)Cl.C[C@H]1C[C@@](N)(CO)CCN1C(=O)OCc1ccccc1>>C[C@H]1C[C@@](N)(CO[Si](C)(C)C(C)(C)C)CCN1C(=O)OCc1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20070219210A1,CCOC(=O)C(=O)CC(=O)c1ccc(C#N)cn1.COc1ccc(NN)cn1>>CCOC(=O)c1cc(-c2ccc(C#N)cn2)n(-c2ccc(OC)nc2)n1,,CCO,,,,val
US20120101134A1,CC(C)Oc1ccc(-c2nc(Br)ns2)cc1Cl.CCOC(=O)CCCc1cccc(B2OC(C)(C)C(C)(C)O2)c1CC>>CCOC(=O)CCCc1cccc(-c2nsc(-c3ccc(OC(C)C)c(Cl)c3)n2)c1CC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20070135461A1,C[Si](C)(C)CCOCn1ccc2c(-c3noc(-c4cccc(C#N)c4)n3)ccnc21.O=C(O)C(F)(F)F>>N#Cc1cccc(-c2nc(-c3ccnc4[nH]ccc34)no2)c1.O=C(O)C(F)(F)F,,[NH4+],[OH-],CO,,val
US20040138222A1,CCC(C#N)c1coc2cccc-2c1>>CCCCNc1coc2cccc-2c1,[Rh],CCO,,[NH4+].[OH-],,val
US05152824,CC1=NNC(c2ccccc2)C1.CON(C)S(=O)(=O)N(C)S(=O)(=O)NC(=O)Oc1ccccc1>>CON(C)S(=O)(=O)N(C)S(=O)(=O)NC(=O)N1N=C(C)CC1c1ccccc1,,c1ccccc1,,,,val
US20120202803A1,COC(OC)C1=NO[C@@H]2COC[C@H]12>>O=CC1=NO[C@@H]2COC[C@H]12,,O,O=C(O)C(F)(F)F,,,val
US20080113966A1,Cc1cc(C2CCNCC2)c(=O)[nH]n1.N[C@@H]1CC[C@@H](c2c(F)cccc2F)Cn2c(C3(C(F)(F)F)CC3)cnc21.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>Cc1cc(C2CCN(C(=O)N[C@@H]3CC[C@@H](c4c(F)cccc4F)Cn4c(C5(C(F)(F)F)CC5)cnc43)CC2)c(=O)[nH]n1,,C1CCOC1,ClC(Cl)Cl,CCN(CC)CC,O=C([O-])[O-].[Na+].[Na+],val
US05414004,CCCS.Cl.O=C1N(c2ccccc2)c2ccccc2C1(CCCCCl)Cc1ccncc1>>CCCSCCCCC1(Cc2ccncc2)C(=O)N(c2ccccc2)c2ccccc21.Cl,,C1CCOC1,,[H-].[Na+],,val
US05262425,CCOC(=O)CC(O)[C@H]1[C@H](NC(=O)OC(C)(C)C)[C@@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1>>CCOC(=O)CC(O)[C@H]1[C@H](N)[C@@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1,,CCOCC,,Cl,,val
US05750754,CCOC(=O)CCCOc1ccc(OCCCc2cnccc2N(C)C)cc1>>CN(C)c1ccncc1CCCOc1ccc(OCCCC(=O)O)cc1,,CO,,Cl,[Na+].[OH-],val
US20140179715A1,CC(C)(C)OC(=O)N1CCn2c1cc(OCc1ccc(Oc3ccc(F)c(F)c3)c(C(F)(F)F)c1)nc2=O>>O=c1nc(OCc2ccc(Oc3ccc(F)c(F)c3)c(C(F)(F)F)c2)cc2n1CCN2,,CN(C)C=O,,,,val
US20020086861A1,CC(C)(N)c1ccccc1.O=S1(=O)N=C(Cl)Nc2cc(Cl)sc21>>CC(C)(NC1=NS(=O)(=O)c2sc(Cl)cc2N1)c1ccccc1,,CCO,,,,val
US20150183778A1,Nc1sccc1-c1ccccc1.O=C1OC(=O)C2=C1CCC2>>O=C(O)C1=C(C(=O)Nc2sccc2-c2ccccc2)CCC1,,C1CCOC1,,CCN(CC)CC,,val
US04937253,CCCCCCCCCCC#Cc1ccccc1C=O>>CCCCCCCCCCCCc1ccccc1C=O,[Pd],,,,,val
US04166131,CCOC(=O)C(=O)c1ccc2c(c1)CC(C(C)C)C2>>CC(C)C1Cc2ccc(C(=O)C(=O)O)cc2C1,,CCO,O,[Na+].[OH-],,val
US20040152742A1,ClCCN1CCCCC1.Nc1ccc(O)c(Cl)c1>>Nc1ccc(OCCN2CCCCC2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100168154A1,Br[Mg]c1ccccc1.c1ccc(CN2CCc3ccccc3C2c2ccccc2)cc1>>c1ccc(CN2CCc3ccccc3C2(c2ccccc2)c2ccccc2)cc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20050176710A1,CCCCOc1ccc(C(=O)NNC(=O)c2ccc(N3CCC(N(C)C)C3)cc2)cc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCCCOc1ccc(-c2nnc(-c3ccc(N4CCC(N(C)C)C4)cc3)s2)cc1,,Cc1ccccc1,,,,val
US05994368,CCOC(=O)c1c(Cl)ccc(O)c1Cl.COCCl>>CCOC(=O)c1c(Cl)ccc(OCOC)c1Cl,,CN(C)C=O,,O,[H-].[Na+],val
US04053474,CI.Cn1ncc2c1ncn1c(S)nnc21>>CSc1nnc2c3cnn(C)c3ncn12,,CN(C)C=O,,[K],,val
US20130123500A1,Cn1ncc(C=O)c1OCc1ccc(Cl)cc1.c1ccc(N2CCNCC2)cc1>>Cn1ncc(C=O)c1N1CCN(c2ccccc2)CC1,,CN(C)C=O,,CCN(CC)CC,,val
US20050277659A1,CC(C)(C)[Si](C)(C)Oc1ccc(C=O)c(Cl)c1>>CC(C)(C)[Si](C)(C)Oc1ccc(CO)c(Cl)c1,,CO,,[BH4-].[Na+],,val
US05696276,C=CCCC(=O)O.CC(C)=CC[C@@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O>>C=CCCC(=O)OC(CC=C(C)C)C1=CC(=O)c2c(O)ccc(O)c2C1=O,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20090012061A1,CC(C)(C)c1cccc(N)c1.O=C(O)c1ccc2ccc(OCc3ccccc3)cc2c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)c1cccc(NC(=O)Nc2ccc3ccc(OCc4ccccc4)cc3c2)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20070185133A1,CN(C)C=C(C#N)C(=O)c1ccc(Br)s1.N=C(N)NCCN1CCNC1=O>>N#Cc1cnc(NCCN2CCNC2=O)nc1-c1ccc(Br)s1,,CN1CCCC1=O,CO,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4cccs4)nc(Cl)c3n2)cc1.Nc1cc(C2CC2)[nH]n1>>c1csc(-c2nc(Nc3cc(C4CC4)[nH]n3)c3[nH]ncc3n2)c1,C1COCCO1,CO,,Cl,,val
US20010027196A1,CSc1nc(N)nc(-c2ccco2)c1C#N.NCCc1ccccc1>>N#Cc1c(NCCc2ccccc2)nc(N)nc1-c1ccco1,,CCO,,,,val
US20040259910A1,CCOc1cccc(C(=O)c2ncc(C=O)c3cc(OCCCOC(C)=O)c(OC)cc23)c1.O>>CCOc1cccc(C(=O)c2ncc(C(=O)O)c3cc(OCCCOC(C)=O)c(OC)cc23)c1,,CC(C)(C)O,O,CC=C(C)C,[Na+].[O-]Cl,val
US20070072896A1,CC(C)(C)OC(=O)N1CCC(C(N)=S)CC1.O=C(CBr)c1c[nH]c2ncc(Br)cc12>>CC(C)(C)OC(=O)N1CCC(c2nc(-c3c[nH]c4ncc(Br)cc34)cs2)CC1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20050014750A1,CS(=O)(=O)OCC[C@@H]1OCCc2cc(C(N)=O)ccc21.C[C@@H]1CN(c2ccc3c4c(cccc24)CC3)CCN1>>C[C@@H]1CN(c2ccc3c4c(cccc24)CC3)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21,,CC#N,,[I-].[K+],,val
US20110275611A1,NC(=O)C1COCCN1.Nc1nc(Cl)cc(Cl)n1>>NC(=O)C1COCCN1c1cc(Cl)nc(N)n1,,CC#N,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20080153810A1,CN1CCCNCC1.O=[N+]([O-])c1ccc2nn([N+](=O)[O-])cc2c1>>CN1CCCN(c2n[nH]c3ccc([N+](=O)[O-])cc23)CC1,,C1CCOC1,,,,val
US20010001799A1,CC(C)I.CCc1cc(C=O)ccc1O>>CCc1cc(C=O)ccc1OC(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030134859A1,CC(C)(C)c1cc(C(=O)CBr)cc(C(C)(C)C)c1O.NC(N)=S>>CC(C)(C)c1cc(-c2cnc(N)s2)cc(C(C)(C)C)c1O,,CC(C)=O,,,,val
US20080176872A1,C[C@H](N)c1ccc(F)cc1.O=[N+]([O-])c1ccc(F)cc1Nc1cc(C2CC2)[nH]n1>>C[C@H](Nc1ccc([N+](=O)[O-])c(Nc2cc(C3CC3)[nH]n2)c1)c1ccc(F)cc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20060229349A1,CNc1ccc([N+](=O)[O-])cc1F.O=C(Cl)CCl>>CN(C(=O)CCl)c1ccc([N+](=O)[O-])cc1F,,Cc1ccccc1,,,,val
US20150141406A1,COc1ncc(C#N)c2c1c(-c1cn[nH]c1)cn2C1CCCC1.NC(=O)CBr>>COc1ncc(C#N)c2c1c(-c1cnn(CC(N)=O)c1)cn2C1CCCC1,,C1CCOC1,,O,[H-].[Na+],val
US20080114007A1,CN1CCNCC1.O=C(O)Cc1ccc([N+](=O)[O-])cc1>>CN1CCN(C(=O)Cc2ccc(N)cc2)CC1,,CCN(CC)CC,ClCCl,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US06172064B2,CC(=O)OC=O.C[C@H](NOC1CCCCO1)[C@@H](CCCc1cccs1)C(=O)O>>C[C@@H]([C@@H](CCCc1cccs1)C(=O)O)N(C=O)OC1CCCCO1,,c1ccncc1,,,,val
US20100076014A1,Cc1cc2[nH]ncc2cc1O.Fc1ccc(I)cc1>>Cc1cc2c(cnn2-c2ccc(F)cc2)cc1O,[Cu]I,C1COCCO1,CCOC(C)=O,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20160185786A1,N.O=C(c1ccc(F)cc1)N1CCC2(CC1)CO2>>NCC1(O)CCN(C(=O)c2ccc(F)cc2)CC1,,CO,,,,val
US20060217372A1,CC1CCC(CCN)CC1.COc1cc(C=O)ccc1Oc1ccc(C(N)=O)cn1>>COc1cc(CNCCC2CCC(C)CC2)ccc1Oc1ccc(C(N)=O)cn1,,CO,,[BH4-].[Na+],,val
US06441206B1,CC(O)C(=O)O.CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C>>CC(O)C(=O)[O-].CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C,,O,,Cc1ccccc1,,val
US05326760,CC(C)CC(NC(CCN1C(=O)c2cc3ccccc3cc2C1=O)C(=O)OC(C)(C)C)C(=O)NCCN1CCOCC1>>CC(C)C[C@H](N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(=O)O)C(=O)NCCN1CCOCC1,,O=C(O)C(F)(F)F,,,,val
US20060106048A1,COc1cc2c(c3c1OC(C)(C)C3)C(c1cccc(N)c1)=NC(C)(C)C2.O=C1CCC(=O)O1>>COc1cc2c(c3c1OC(C)(C)C3)C(c1cccc(NC(=O)CCC(=O)O)c1)=NC(C)(C)C2,,C1CCOC1,,CCOCC,,val
US20080076917A1,CC[Si](Cl)(CC)CC.C[C@@H](C(=O)c1cn2cnc(C(=O)c3cccnc3)c2s1)[C@H]1NC(=O)[C@@H]1[C@@H](C)O>>CC[Si](CC)(CC)O[C@H](C)[C@H]1C(=O)N[C@@H]1[C@@H](C)C(=O)c1cn2cnc(C(=O)c3cccnc3)c2s1,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US06197770B1,BrCCOCCBr.Nc1ccc(I)cc1>>Ic1ccc(N2CCOCC2)cc1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US04316839,CCOC(=O)c1ncn2c1CN(C)C(=O)c1ccccc1-2>>CN1Cc2c(CO)ncn2-c2ccccc2C1=O,,C1CCOC1,,Cl,[BH4-].[Li+],val
US20120028941A1,CO.Cc1c(F)cc(C(=O)O)c(Cl)c1[N+](=O)[O-]>>COC(=O)c1cc(F)c(C)c([N+](=O)[O-])c1Cl,,CO,O,C[Si](C)(C)Cl,,val
US20090048249A1,CN1CCN(c2ccc(N)c(N)c2)CC1.O=C(O)c1n[nH]c2ncc(Br)cc12>>CN1CCN(c2ccc(NC(=O)c3n[nH]c4ncc(Br)cc34)c(N)c2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060270692A1,CCOC(=O)c1nn(CC(=O)Nc2cccc(F)c2)cc1[N+](=O)[O-]>>CCOC(=O)c1nn(CC(=O)Nc2cccc(F)c2)cc1N,[Pd],CO,ClCCl,,,val
US20110045101A1,CO.N#CCc1nc(Br)c(-c2c(F)cccc2F)n1-c1ccc(Cl)cc1.O=S(Cl)Cl>>COC(=O)Cc1nc(Br)c(-c2c(F)cccc2F)n1-c1ccc(Cl)cc1,,CO,,CCOC(C)=O,,val
US20100305070A1,CCOC(CBr)OCC.COc1cccc(C=O)c1O>>CCOC(COc1c(C=O)cccc1OC)OCC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110301155A1,CN(Cc1cnc(Nc2n[nH]c3ccc(-c4ncccc4Cl)cc23)s1)C(=O)OC(C)(C)C>>CNCc1cnc(Nc2n[nH]c3ccc(-c4ncccc4Cl)cc23)s1,,CCOC(C)=O,,Cl,,val
US04897393,Nc1cc([N+](=O)[O-])ccc1O.O=Cc1ccccc1>>O=[N+]([O-])c1ccc(O)c(N=Cc2ccccc2)c1,,CCO,,,,val
US20150141428A1,CC(C)(C)OC(=O)n1cc(CCl)c2cccnc21.CC1(C)CCN(c2ccc(SC(F)(F)F)cc2)C(=O)N1>>CC1(C)CCN(c2ccc(SC(F)(F)F)cc2)C(=O)N1Cc1c[nH]c2ncccc12,,CN(C)C=O,,[H-].[Na+],,val
US20120015942A1,COC(=O)c1cc(Br)cc(C(F)(F)F)c1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>COC(=O)c1cc(-c2cnn(C)c2)cc(C(F)(F)F)c1,,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US05130119,CC(=O)OCC(=O)Nc1cc(F)cc(C(=O)NCC(F)(F)F)c1O>>O=C(CO)Nc1cc(F)cc(C(=O)NCC(F)(F)F)c1O,,[Na+],[OH-],,,val
US20130210844A1,Nc1cccc(C(F)(F)F)c1.O=[N+]([O-])c1cccc2c(Cl)ccnc12>>O=[N+]([O-])c1cccc2c(Nc3cccc(C(F)(F)F)c3)ccnc12,,O,,,,val
US20030225266A1,CC(CNS(=O)(=O)C(C)C)Oc1ccc(Br)cc1.COc1cccc(B(O)O)c1>>COc1cccc(-c2ccc(OC(C)CNS(=O)(=O)C(C)C)cc2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US05952327,C=O.CC(C)OP([O-])OC(C)C>>CC(C)OP(=O)(CO)OC(C)C,,CCN(CC)CC,,,,val
US20160108016A1,CC(C)(C(=O)O)c1cc(O)cc(O)c1.CI>>COC(=O)C(C)(C)c1cc(O)cc(O)c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US06130237,Cn1cc([N+](=O)[O-])cc1C=O.O=C(O)CC(=O)O>>Cn1cc([N+](=O)[O-])cc1/C=C/C(=O)O,C1CCNCC1,c1ccncc1,,O=S(=O)(O)O,,val
US05891899,CCOC(=O)C(C(=O)c1ccc(C(=O)OC)c(OC)c1)C1c2ccccc2Oc2ccccc21>>COC(=O)c1ccc(C(=O)CC2c3ccccc3Oc3ccccc32)cc1OC,,CS(C)=O,O,,,val
US20090093504A1,Cc1nc2ccc(CN)cc2c(=O)n1C1CCC(=O)NC1=O.O=C(O)c1cccc(C(F)(F)F)c1>>Cc1nc2ccc(CNC(=O)c3cccc(C(F)(F)F)c3)cc2c(=O)n1C1CCC(=O)NC1=O,,CN(C)C=O,,Cl,O=C(n1ccnc1)n1ccnc1,val
US20140221332A1,O=C(NNC(=O)C1CCCC1)c1ccc(C#Cc2cccc(F)c2)cc1>>Fc1cccc(C#Cc2ccc(-c3nnc(C4CCCC4)o3)cc2)c1,,O=P(Cl)(Cl)Cl,,,,val
US20140243302A1,BrP(Br)Br.COc1cc(OC)c2nccc(O)c2n1>>COc1cc(OC)c2nccc(Br)c2n1,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20060276469A1,Cc1nc2ccc(I)cc2c(Cl)c1S(C)(=O)=O.O[C@@H]1CCCNC1>>Cc1nc2ccc(I)cc2c(N2CCC[C@@H](O)C2)c1S(C)(=O)=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04479942,COc1ccc(C[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H]2[C@@H](C(=O)O)O[C@@H](n3cnc4c(N)ncnc43)[C@@H]2O)cc1>>COc1ccc(C[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H]2[C@@H](C(=O)O)O[C@@H](n3cnc4c(N)ncnc43)[C@@H]2O)cc1,,O=CO,,,,val
US20040102436A1,COC(=O)C1CCc2c(OCc3ccccc3)cccc2C1O>>COC(=O)C1=Cc2cccc(OCc3ccccc3)c2CC1,,c1ccncc1,,Cc1ccc(S(=O)(=O)Cl)cc1,,val
US20110060026A1,O=Cc1ccccc1S(=O)(=O)c1ccc(F)cc1>>O=S(=O)(c1ccc(F)cc1)c1ccccc1CO,,CO,Cl,[BH4-].[Na+],,val
US20040048882A1,Cn1cncc1C(O)(c1ccc(CCl)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2C.S=c1[nH]ccs1>>Cn1cncc1C(O)(c1ccc(CSc2nccs2)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2C,,C1CCOC1,CCN(CC)CC,O,,val
US20120029026A1,COC(=O)c1cccc(OCc2nc3ccc(O)cc3n2C)c1.Fc1cc(Br)cnc1F>>COC(=O)c1cccc(OCc2nc3ccc(Oc4ncc(Br)cc4F)cc3n2C)c1,I[Cu]I,CN(C)C=O,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US20080167307A1,O=S(Cl)Cl.OCc1cnc(-c2ccccc2)nc1>>ClCc1cnc(-c2ccccc2)nc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20060205737A1,COc1c(Cl)cc(F)cc1C(C)N.CS(=O)(=O)c1ccc(F)cc1F>>COc1c(Cl)cc(F)cc1C(C)Nc1cc(F)ccc1S(C)(=O)=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,ClCCl,val
US20050222410A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(Cl)nc1.c1ccc(CN2CCNCC2)cc1>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(N2CCN(Cc3ccccc3)CC2)nc1,,CC(=O)N(C)C,,,,val
US20130045497A1,CC1(C)OB(c2ccc(C(=O)O)c3ccccc23)OC1(C)C>>CC1(C)OB(c2ccc(CO)c3ccccc23)OC1(C)C,,C1CCOC1,,B,CO,val
US20140243362A1,CC(=O)c1ccc(S(=O)(=O)N(CC(C)C)c2ccc(C)cc2C)cc1.Cc1nnn(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>Cc1ccc(N(CC(C)C)S(=O)(=O)c2ccc(C(C)(O)Cc3nnn(C(c4ccccc4)(c4ccccc4)c4ccccc4)n3)cc2)c(C)c1,,C1CCOC1,,[Li]CCCC,,val
US20100010053A1,CCOC(=O)CCc1cc2cc(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)cc(F)c2[nH]1>>CC(C)Oc1ccc(-c2nc(-c3cc(F)c4[nH]c(CCC(=O)O)cc4c3)no2)cc1Cl,,CC(C)O,,Cl,[Na+].[OH-],val
US04315009,CCO.O=C(CBr)c1cccc([N+](=O)[O-])c1>>O=C(CO)c1cccc([N+](=O)[O-])c1,,CCO,,CC(=O)[O-].[Na+],,val
US20090099155A1,Cc1cccc2cccnc12.O=C1CCC(=O)N1Br>>BrCc1cccc2cccnc12,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20020193596A1,COC(=O)[C@H](CCSC)NC(=O)c1ccc(COc2cccnc2)cc1-c1ccccc1C>>CSCC[C@H](NC(=O)c1ccc(COc2cccnc2)cc1-c1ccccc1C)C(=O)O,,C1CCOC1,,[Li+].[OH-],,val
US20050049288A1,CC1CCCCC1N.Cc1ccc(C(=O)NC2CC2)cc1-n1ncc(C(=O)O)c1N>>Cc1ccc(C(=O)NC2CC2)cc1-n1ncc(C(=O)NC2CCCCC2C)c1N,,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20100160388A1,COc1cc(N)c(Br)cc1OC.O=C(Cl)Cl>>COc1cc(Br)c(N=C=O)cc1OC,CN(C)c1ccncc1,Cc1ccccc1,,c1ccncc1,,val
US20100099680A1,COc1cc([N+](=O)[O-])cc(S(C)(=O)=O)c1>>COc1cc(N)cc(S(C)(=O)=O)c1,[Pd],CO,ClCCl,,,val
US20020165282A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCCCCNCC1(c2ccc(CO)cc2)CC1>>CCCCCCCN(CC1(c2ccc(CO)cc2)CC1)C(=O)OC(C)(C)C,,C1CCOC1,,[Na+].[OH-],,val
US05958954,CC1(C)CCC(=O)c2cc(N)ccc21.CCOC(=O)c1ccc(N=O)cc1>>CCOC(=O)c1ccc(N=Nc2ccc3c(c2)C(=O)CCC3(C)C)cc1,,CC(=O)O,,,,val
US20060147924A1,Nc1nc(Cl)c2ncn([C@@H]3O[C@]4(COC(=O)c5ccccc5)CO[C@@H]3[C@@H]4OCc3ccccc3)c2n1>>Nc1nc(Cl)c2ncn([C@@H]3O[C@@]4(CO)CO[C@@H]3[C@@H]4OCc3ccccc3)c2n1,,C1COCCO1,,CC(=O)O,[Na+].[OH-],val
US05246948,O=C(Cl)c1ccccc1.c1ccc(CNCCCSc2ccncc2)nc1>>O=C(c1ccccc1)N(CCCSc1ccncc1)Cc1ccccn1,,ClCCl,,CCN(CC)CC,,val
US20070287724A1,O=C(OO)c1cccc(Cl)c1.OC1(Cn2c(CCl)nc3cnc4ccccc4c32)CCCCC1>>[O-][n+]1cc2nc(CCl)n(CC3(O)CCCCC3)c2c2ccccc21,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20040127576A1,CCC1=C2CCc3cc(O)ccc3C2(C)CCC1=O>>CC[C@@H]1C(=O)CC[C@@]2(C)c3ccc(O)cc3CC[C@H]12,[Pd],CO,,,,val
US20030078251A1,CCOC(=O)c1oc2ccc(NC(=O)C[C@H]3O[C@H](c4cccc(OC)c4OC)c4cc(Cl)ccc4N(CC(C)(C)COC(C)=O)C3=O)cc2c1OC.Cl>>COc1cccc([C@H]2O[C@H](CC(=O)Nc3ccc4oc(C(=O)O)c(OC)c4c3)C(=O)N(CC(C)(C)CO)C3=C2CC(Cl)(Cl)C=C3)c1OC,,C1CCOC1,CCO,[Na+].[OH-],,val
US03993646,CC1(CBr)S[C@@H]2C(NC(=O)COc3ccccc3)C(=O)N2C1C(=O)OCC(Cl)(Cl)Cl>>CC1=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(NC(=O)COc3ccccc3)[C@H]2SC1,,c1ccncc1,,ClC(Cl)Cl,,val
US04209517,CC(=O)CN1CCOCC1.O=Cc1ccc2c(c1)OCO2>>O=C(C=Cc1ccc2c(c1)OCO2)CN1CCOCC1,,[Na+],[OH-],,,val
US20090163512A1,CC(C)(C)OC(=O)NCCOc1ccc(Cl)cc1C=O.O=C1Cc2ccc(Cl)cc2N1>>CC(C)(C)OC(=O)NCCOc1ccc(Cl)cc1/C=C1\C(=O)Nc2cc(Cl)ccc21,,CO,,C1CCNC1,,val
US04410537,CCOC(=O)C(C)(C)CCCBr.COc1cccc(O)c1C=O>>CCOC(=O)C(C)(C)CCCOc1cccc(OC)c1C=O,,CCO,,[I-].[K+],O=C([O-])O.[Na+],val
US20150037280A1,Nc1cc(Cl)ccn1.Nc1ccc(O)cc1>>Nc1ccc(Oc2ccnc(N)c2)cc1,,CS(C)=O,,CO[Na],,val
US20100184739A1,O=[N+]([O-])c1ccc(N2CC(F)(F)C[C@H]2CBr)cc1C(F)(F)F>>C[C@@H]1CC(F)(F)CN1c1ccc(N)c(C(F)(F)F)c1,[Pd],CCOC(C)=O,,,,val
US20030013875A1,O=S(=O)(OCC[C@H](O)C1CCCCC1)c1ccc(Br)cc1>>O=C(CCOS(=O)(=O)c1ccc(Br)cc1)C1CCCCC1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20050222408A1,CCN(CC)c1ccc(C=O)cc1.O=C(c1ccc([N+](=O)[O-])o1)N1CCNCC1>>CCN(CC)c1ccc(CN2CCN(C(=O)c3ccc([N+](=O)[O-])o3)CC2)cc1,,C1CCOC1,,CC(=O)O,,val
US20150238473A1,COC(=O)c1ccc(C=O)cc1.SCCCS>>COC(=O)c1ccc(C2SCCCS2)cc1,,ClCCl,,CCOCC,FB(F)F,val
US20060025459A1,COC(=O)c1cc(OCc2ccccc2)cc(C(=O)O)c1.C[Si](C)(C)CCO.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COC(=O)c1cc(NC(=O)OCC[Si](C)(C)C)cc(OCc2ccccc2)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20020198195A1,CC(C)Br.CCOC(=O)c1ccc(O)c(O)c1>>CCOC(=O)c1ccc(OC(C)C)c(O)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090286783A1,CCCS(=O)(=O)Nc1ccc(F)c(C(O)c2c[nH]c3ncnc(C)c23)c1F>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncnc(C)c23)c1F,,C1CCOC1,CCOC(C)=O,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US05965741,COC(=O)c1ccc(CBr)nc1>>O=C(O)c1cccnc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140343294A1,CCOC(=O)c1nn(-c2ccc(Cl)cc2Cl)c2c1CCCc1ccsc1-2>>O=C(O)c1nn(-c2ccc(Cl)cc2Cl)c2c1CCCc1ccsc1-2,,C1CCOC1,O,Cl,[Li+].[OH-],val
US05244894,CN.COC(=O)c1ccnc(NCCCN2CCN(c3cccc(Cl)c3)CC2)n1.Cl>>CNC(=O)c1ccnc(NCCCN2CCN(c3cccc(Cl)c3)CC2)n1.Cl,,CC(C)O,,CO,,val
US20090048258A1,COc1cc2c(cc1C(=O)CCC(=O)O)CCCC2.Nc1nc(-c2ccccc2)c(Cc2ccccc2)s1>>COc1cc2c(cc1C(=O)CCC(=O)Nc1nc(-c3ccccc3)c(Cc3ccccc3)s1)CCCC2,,CC#N,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20140038923A1,CC(C)(C)c1cc(CN=[N+]=[N-])nn1-c1ccc(S(C)(=O)=O)cc1>>CC(C)(C)c1cc(CN)nn1-c1ccc(S(C)(=O)=O)cc1,[Pd],CCOC(C)=O,,,,val
US20070078165A1,Cc1cc2ncn(C3CCNCC3)c2cc1F.O=CC1Cc2ccc(F)cc2C1>>Cc1cc2ncn(C3CCN(CC4Cc5ccc(F)cc5C4)CC3)c2cc1F,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20080139639A1,COC(=O)c1cn(S(=O)(=O)c2ccccc2)c(Br)c1-c1ccccc1.OB(O)c1ccccc1>>COC(=O)c1c[nH]c(-c2ccccc2)c1-c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20120316147A1,COC(CNC(=O)C(C)(C)NC(=O)OCc1ccccc1)OC>>CC(C)(NC(=O)OCc1ccccc1)C(=O)NCC=O,,C1CCOC1,,CCOC(C)=O,Cl,val
US20110059951A1,CCC(CN1CCNCC1)n1cc(-c2ncnc3c2ccn3COCC[Si](C)(C)C)cn1.O=C(Cl)c1ccccc1.O=C(O)C(F)(F)F>>CCC(CN1CCN(C(=O)c2ccc(F)cc2)CC1)n1cc(-c2ncnc3[nH]ccc23)cn1,,CO,,ClCCl,,val
US20110130453A1,COC(=O)Cc1cccc(Oc2ccc(Br)cc2C=O)c1.NCc1ccccc1>>COC(=O)Cc1cccc(Oc2ccc(Br)cc2CNCc2ccccc2)c1,CC(=O)O,ClCCl,,[BH3-]C#N.[Na+],,val
US04500526,Nc1nc2cnccc2s1.O=C(Cl)Oc1ccccc1>>O=C(Nc1nc2cnccc2s1)Oc1ccccc1,,CN(C)C=O,,c1ccncc1,,val
US20090023710A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.Nc1ccccc1Oc1ccc(OC(F)(F)F)cc1>>CC(C)(C)OC(=O)N1CCC(C(=O)Nc2ccccc2Oc2ccc(OC(F)(F)F)cc2)CC1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20100056511A1,Cc1cc(C)nc(C)c1.O=C/C=C/c1ccc([N+](=O)[O-])cc1>>Cc1cc(C)nc(C=CC=Cc2ccc([N+](=O)[O-])cc2)c1,,CC(=O)OC(C)=O,,CC(=O)[O-].[Na+],,val
US04822902,CC(C)(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)CO.CS(=O)(=O)Cl>>CC(C)(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)COS(C)(=O)=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20050245530A1,CC(C)(C)C(=O)Nc1ccc(Oc2ccnc(N)c2)cc1F>>Nc1cc(Oc2ccc(N)c(F)c2)ccn1,,CO,,Cl,,val
US04659728,COc1ccc(-c2oc(CCC(=O)O)nc2-c2ccccc2)cc1>>O=C(O)CCc1nc(-c2ccccc2)c(-c2ccc(O)cc2)o1,,ClCCl,,BrB(Br)Br,O,val
US20130029938A1,COc1cc(C(=O)c2ccccc2)c(OC)cc1Br>>COc1cc(C(=O)c2ccccc2)c(O)cc1Br,,ClCCl,,ClB(Cl)Cl,,val
US04242519,COC(=O)C(C)(SC)c1cccc(C2(c3ccccc3)OCCO2)c1>>COC(=O)C(C)(SC)c1cccc(C(=O)c2ccccc2)c1,,O,,CO,Cl,val
US04122183,Cc1coc(NC(=O)C(C)C)n1.Clc1cccc(CBr)c1>>Cc1coc(N(Cc2cccc(Cl)c2)C(=O)C(C)C)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04021434,CCCC1=C(C(=O)OCC)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OCC)=C(C)N1.CCOCCl>>CCCC1=C(C(=O)OCC)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OCC)=C(C)N1COCC,,CCCCCC,,c1ccccc1,,val
US20130296377A1,Cc1ccc(S(=O)(=O)n2ccc3c(C(O)(c4nc5cc(C#N)ccc5[nH]4)C(F)(F)F)c(S(C)(=O)=O)cc(C)c32)cc1>>Cc1cc(S(C)(=O)=O)c(C(O)(c2nc3cc(C#N)ccc3[nH]2)C(F)(F)F)c2cc[nH]c12,,CCO,,C,C[O-].[Na+],val
US04666930,CN=C=O.NNC1NS(=O)(=O)c2ccccc21>>CNC(=O)NNC1=NS(=O)(=O)c2ccccc21,,C1COCCO1,,,,val
US20110003787A1,CN1CCNCC1.O=C(O)c1cnc(O)cn1.O=S(Cl)Cl>>CN1CCN(C(=O)c2cnc(Cl)cn2)CC1,CN(C)C=O,,,CCN(C(C)C)C(C)C,O,val
US20130245042A1,O=C(CC1CC1)NNc1nccc(NC[C@H]2C[C@@H]2c2ccc(F)cc2)c1C(F)(F)F>>Fc1ccc([C@H]2C[C@@H]2CNc2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cc1,,C1CCOC1,CCOC(C)=O,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US20100256361A1,C1COCCN1.Nc1nc(-c2ccco2)c(C(=O)C2CC2)s1.O=C(Br)CBr>>O=C(CN1CCOCC1)Nc1nc(-c2ccco2)c(C(=O)C2CC2)s1,,C1CCOC1,O,CCN(CC)CC,,val
US04029787,CCCCN1CCNCC1.NS(=O)(=O)c1cc(C(=O)O)c(Cl)cc1F>>CCCCN1CCN(c2cc(Cl)c(C(=O)O)cc2S(N)(=O)=O)CC1,,O,,,,val
US20160159752A1,COc1ccc(S(=O)(=O)N[C@@H](CCc2c(F)cncc2NC(=O)[C@@H](N=[N+]=[N-])[C@@H](c2ccc(Cl)cc2)C2CCOCC2)CN(C[C@@H](C)O)C(=O)OC(C)(C)C)cc1>>COc1ccc(S(=O)(=O)N2[C@@H](CCc3c(F)cncc3NC(=O)[C@@H](N=[N+]=[N-])[C@@H](c3ccc(Cl)cc3)C3CCOCC3)CN(C(=O)OC(C)(C)C)C[C@@H]2C)cc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130040978A1,CC(C)=CCBr.Oc1ccc(Br)cc1Cl>>CC(C)=CCOc1ccc(Br)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20010006973A1,NC1CCC(=O)NC1=O.O=C1OC(=O)c2c(Cl)cccc21>>O=C1CCC(N2C(=O)c3cccc(Cl)c3C2=O)C(=O)N1,,CC(=O)O,,Cl,CC(=O)[O-].[Na+],val
US20080275056A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cnc(OC3CCN(C(=O)OC(C)(C)C)CC3)c3ccccc23)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cnc(OC3CCNCC3)c3ccccc23)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160060267A1,CCc1c(C(=O)N(C)OC)[nH]c2c(C#N)cnn2c1=O>>CCc1c(C=O)[nH]c2c(C#N)cnn2c1=O,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100204221A1,FC1(F)CCNCC1.O=[N+]([O-])c1ccc(F)c(F)c1>>O=[N+]([O-])c1ccc(N2CCC(F)(F)CC2)c(F)c1,,CC#N,,CCN(CC)CC,Cl,val
US20080182838A1,N#Cc1cnc(N2CC(Oc3cc(F)ccc3Br)C2)cn1.[N-]=[N+]=[N-]>>Fc1ccc(Br)c(OC2CN(c3cnc(-c4nnn[nH]4)cn3)C2)c1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20060089393A1,Cc1ccc(C(=O)NC2CC2)cc1-c1ccc(-c2nnc(CN=[N+]=[N-])o2)cc1>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc(-c2nnc(CN)o2)cc1,[Pd],CCO,,[H][H],,val
US06569849B1,Br.COCC(C)=C1c2ccccc2CCc2ccccc21>>CC(CBr)=C1c2ccccc2CCc2ccccc21,,CC(=O)O,O,,,val
US04062869,O=C(OCc1ccccc1)C(=O)c1c[nH]c2ccccc12>>OCCc1c[nH]c2ccccc12,,CC(C)O,O,[BH4-].[Na+],,val
US20020049223A1,N.O=C(O)c1cn(C2CC2)c2c(F)c(-c3cc4c(s3)CCCC4O)cc(F)c2c1=O>>Nc1cc(-c2cc3c(s2)CCCC3O)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1,,CN1CCCC1=O,O,CC(=O)O,,val
US20100292196A1,BrC(Br)(Br)Br.OCC1CC2(C1)OCCO2>>BrCC1CC2(C1)OCCO2,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05665718,N.O=C(O)c1ncn2c1[C@@H]1CCN1C(=O)c1cc(F)ccc1-2>>NC(=O)c1ncn2c1[C@@H]1CCN1C(=O)c1cc(F)ccc1-2,,CN(C)C=O,,O,O=C(n1ccnc1)n1ccnc1,val
US04610991,COc1ccc(Nc2ccncc2)c(C(=O)N2CCCCC2)c1>>O=C(c1cc(O)ccc1Nc1ccncc1)N1CCCCC1,,ClCCl,,BrB(Br)Br,,val
US20150218111A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1cc(Br)cc2c1NC(=O)C(N)N=C2c1ccccc1>>COc1cc(Br)cc2c1NC(=O)C(NC(=O)OC(C)(C)C)N=C2c1ccccc1,,C1COCCO1,,CCN(CC)CC,,val
US04415573,CC(=O)OC(C)=O.O=c1[nH]c(=O)n(COCCO)cc1F>>CC(=O)OCCOCn1cc(F)c(=O)[nH]c1=O,,c1ccncc1,,,,val
US20100311745A1,CC(C)(C)OC(=O)N1Cc2ccc(O)cc2C1.Cl>>Cl.Oc1ccc2c(c1)CNC2,,C1COCCO1,,,,val
US20080108826A1,COc1ccc(C2(O)CCOCC2)cc1>>COc1ccc(C2CCOCC2)cc1,[Pd],CCO,,Cl,,val
US08937041B2,CCOC(=O)[C@@]12C[C@H]1C=CCCCCC[C@H](N)C(=O)N1C[C@H](Oc3nc4ccccc4c4ccccc34)C[C@H]1C(=O)N2.Cc1cc(C(=O)O)no1>>CCOC(=O)[C@@]12C[C@H]1C=CCCCCC[C@H](NC(=O)c1cc(C)on1)C(=O)N1C[C@H](Oc3nc4ccccc4c4ccccc34)C[C@H]1C(=O)N2,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US06221864B1,NCC1CN(Cc2ccccc2)CCO1>>NC[C@H]1CN(Cc2ccccc2)CCO1,,CCO,,,,val
US20150038488A1,COc1ccc([C@@H](C)N2C[C@H]([C@H](C)O)CC2=O)cc1.Oc1cc(Br)cc2ncn(C3CC3)c12>>COc1ccc([C@@H](C)N2C[C@H]([C@@H](C)Oc3cc(Br)cc4ncn(C5CC5)c34)CC2=O)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110152243A1,CC(C)(C)OC(=O)N1CCC2CNCCC21.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC2CN(C(=O)OCc3ccccc3)CCC21,,ClCCl,,,,val
US20160113928A1,CN(Cc1ccc(F)cc1C(F)(F)F)C1CCN(c2nnc(Cl)c3ccccc23)C1.Cn1nccc1B1OC(C)(C)C(C)(C)O1>>CN(Cc1ccc(F)cc1C(F)(F)F)C1CCN(c2nnc(-c3ccnn3C)c3ccccc23)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US04251263,CC(C)CN.O=C(Cl)c1cccnc1Oc1cccc(Cl)c1>>CC(C)CNC(=O)c1cccnc1Oc1cccc(Cl)c1,,Cc1ccccc1,,,,val
US20140271543A1,COc1ncccc1Nc1nc(N[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)nc(N2CCOCC2)c1C>>Cc1c(Nc2ccc[nH]c2=O)nc(N[C@@H]2CCCNC2)nc1N1CCOCC1,,C1COCCO1,,Cl,,val
US20130053569A1,Cl.O=C1C=C2CN(C(c3ccccc3)(c3ccccc3)c3ccccc3)CCC2S1>>Cl.O=C1C=C2CNCCC2S1,,CC(C)=O,,,,val
US20050131015A1,COC(=O)[C@H](CO)NC(c1ccccc1)(c1ccccc1)c1ccccc1.O=[N+]([O-])c1ncc[nH]1>>COC(=O)[C@H](Cn1ccnc1[N+](=O)[O-])NC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20140221435A1,COC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2F)cn1.COc1cc(F)ccc1O>>COC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(F)cc2OC)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060063762A1,CC[Si](CC)(CC)O[C@@H](CN[C@H](C)Cc1c[nH]c2c(C(=O)OC)cccc12)c1cccnc1>>COC(=O)c1cccc2c(C[C@@H](C)NC[C@H](O)c3cccnc3)c[nH]c12,,O=C(O)C(F)(F)F,,,,val
US20040122057A1,CCI.CCOC(=O)C(O)c1c(F)cc(OC)cc1F>>CCOC(=O)C(OCC)c1c(F)cc(OC)cc1F,,Cc1ccccc1,,,,val
US05650410,BrP(Br)Br.COc1ccc(-c2nc(CCO)nc3cc(OC)c(OC)cc23)cc1OC>>COc1ccc(-c2nc(CCBr)nc3cc(OC)c(OC)cc23)cc1OC,,c1ccccc1,,O=C([O-])O.[Na+],,val
US20110172297A1,CCOC(=O)C1=C(OS(=O)(=O)C(F)(F)F)COCC1.OB(O)c1ccccc1>>CCOC(=O)C1=C(c2ccccc2)COCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US05475003,Nc1ccc2c(c1)CCC2.O=C1CCC(=O)N1Br>>Nc1cc2c(cc1Br)CCC2,,CN(C)C=O,,,,val
US20070232627A1,CCOC(=O)C(C)(NC(=O)c1ccc(Sc2ccc(NC(=O)OC(C)(C)C)cc2)c(Nc2ncnc3nc(C(C)C)ccc23)c1)c1ccccc1>>CCOC(=O)C(C)(NC(=O)c1ccc(Sc2ccc(N)cc2)c(Nc2ncnc3nc(C(C)C)ccc23)c1)c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020061890A1,Cc1nsc(-c2ccc(F)cc2)n1.FC(F)(F)c1cccc(N2CCNCC2)c1>>Cc1nsc(-c2ccc(N3CCN(c4cccc(C(F)(F)F)c4)CC3)cc2)n1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20050197370A1,CC(C)(C)[Si](C)(C)Oc1ccc(C#CCCn2ccnn2)cc1>>Oc1ccc(C#CCCn2ccnn2)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20030158245A1,ClCc1ccc(Cl)cc1.Cn1ncc2c1-c1c(Oc3ccc(O)cc3)sc(C(N)=O)c1CC2>>Cn1ncc2c1-c1c(Oc3ccc(OCc4ccc(Cl)cc4)cc3)sc(C(N)=O)c1CC2,,CN(C)C=O,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20070124152A1,CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCCN(C)C(=O)OCc2ccccc2)c1=O.NCCO>>CN(CCCn1c(=O)c(C(=O)NCCO)c(O)c2ncc(Cc3ccc(F)cc3)cc21)C(=O)OCc1ccccc1,,CCO,,,,val
US20090118500A1,CC(=O)c1csc(-c2ccc(Cl)c(Cl)c2)c1O.Cn1nccc1CNC(=O)c1ccc(C(=O)NN)s1>>CC(=NNC(=O)c1ccc(C(=O)NCc2ccnn2C)s1)c1csc(-c2ccc(Cl)c(Cl)c2)c1O,,CN(C)C=O,,O,,val
US20060094768A1,CO.COC(=O)CCc1ccc(OCc2ccc(-c3ccc(C(F)(F)F)cc3)s2)cc1C>>Cc1cc(OCc2sc(-c3ccc(C(F)(F)F)cc3)cc2C)ccc1CCC(=O)O,,CO,,C1CCOC1,[Na+].[OH-],val
US20110092547A1,CCOC(=O)C1CCC(Oc2ccc([N+](=O)[O-])cn2)CC1>>CCOC(=O)C1CCC(Oc2ccc(N)cn2)CC1,[Pd],CCOC(C)=O,,,,val
US20130225554A1,NC(=O)CONC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OCc1ccccc1>>NC(=O)CONC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2O,[Pd],CO,,,,val
US20140275085A1,COc1nc(NC2CCCC2)ncc1-c1ccc(Oc2ccnc(-c3cnn(C)c3)c2)c(C)n1>>Cc1nc(-c2cnc(NC3CCCC3)[nH]c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1,,CC(=O)O,,Br,,val
US04958026,CN(C)CCc1ccc(N)c2[nH]ncc12.CS(=O)(=O)Cl>>CN(C)CCc1ccc(NS(C)(=O)=O)c2[nH]ncc12.Cl,,C1CCOC1,CN(C)C=O,,,val
US20050148648A1,COc1ccc(C2(CN)CCCC2)cc1OC.O=C(Cl)c1cc2ccccc2o1>>COc1ccc(C2(CNC(=O)c3cc4ccccc4o3)CCCC2)cc1OC,,C1COCCO1,,CCN(CC)CC,,val
US20100093724A1,CC[C@H](NS(=O)C(C)(C)C)c1cnn(S(=O)(=O)c2ccc(C)cc2)c1>>CC[C@H](N)c1cn[nH]c1,,C1COCCO1,CO,Cl,,val
US20050267149A1,COC(=O)c1ccccc1COc1cccc(CCOc2ccc(OCc3ccccc3)cc2)c1>>O=C(O)c1ccccc1COc1cccc(CCOc2ccc(OCc3ccccc3)cc2)c1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US05753679,O=C(Cl)c1ccc([N+](=O)[O-])cc1.OC1CCN(Cc2ccccc2)CC1>>O=C(OC1CCN(Cc2ccccc2)CC1)c1ccc([N+](=O)[O-])cc1,,Cc1ccccc1,,CCN(CC)CC,,val
US04971982,CC1(C)CC(c2ccccn2)c2cc(C(N)=O)ccc2O1>>CC1(C)CC(c2ccccn2)c2cc(C#N)ccc2O1,,O=P(Cl)(Cl)Cl,,,,val
US20070004753A1,C[Si](C)(C)C#N.Nc1ccc(C(=O)O)cc1.O=C1CCC1>>N#CC1(Nc2ccc(CO)cc2)CCC1,,ClCCl,,,,val
US20050267100A1,CCOC1=Nc2ccccc2N(CC(=O)N(c2ccccc2)C(C)C)C(=O)C1.NNC(=O)c1cccc(O)c1>>CC(C)N(C(=O)CN1C(=O)Cc2nnc(-c3cccc(O)c3)n2-c2ccccc21)c1ccccc1,,CC(=O)O,,,,val
US05232929,O=C1CC(c2ccccc2)C(=NO)C(c2ccccc2)N1>>NC1C(c2ccccc2)CC(=O)NC1c1ccccc1,[Ni],,,,,val
US20130079313A1,COC(=O)Cc1ccc(OCC2CC2)c([N+](=O)[O-])c1>>COC(=O)Cc1ccc(OCC2CC2)c(N)c1,O=[Pt]=O,CO,,,,val
US20120157479A1,CC(C)(C)OC(=O)N1C[C@H](CO)[C@@H](O[Si](C)(C)C(C)(C)C)C1>>CC(C)(C)OC(=O)N1C[C@H](C=O)[C@@H](O[Si](C)(C)C(C)(C)C)C1,,CCOCC,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05141956,CCOC(=O)Cl.NCCOc1ccc(Oc2cccc(Cl)c2)cc1>>CCOC(=O)NCCOc1ccc(Oc2cccc(Cl)c2)cc1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US20130267510A1,C=C(C)CBr.COC(=O)c1cccc(O)c1>>C=C(C)COc1cccc(C(=O)OC)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20020077330A1,CC(C)(CO)NCC(=O)OC(C)(C)C.CCO.Cl>>CCOC(=O)CNC(C)(C)CO.Cl,,CCO,,CCOC(C)=O,CO,val
US04273932,CCOC(=O)C(=CNC1=CC(=O)CCC1)C(=O)OCC>>CCOC(=O)c1cnc2c(c1O)C(=O)CCC2,,c1ccc(Oc2ccccc2)cc1,,CCCCCC,,val
US05651954,CC(=NN)C(C)(C)NCCCNC(C)(C)C(C)=NO.NCCN>>CC(=NO)C(C)(C)NCCN,,CO,O,,,val
US20120289526A1,CC(C)Oc1cccc(O)c1.O=[N+]([O-])c1ccc(Cl)nc1>>CC(C)Oc1cccc(Oc2ccc([N+](=O)[O-])cn2)c1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US04533498,CCOC(=O)N1CC2CCC1CC2N=[N+]=[N-]>>CN1CC2CCC1CC2N,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04041232,COC(=O)[C@@H]1[C@@H](O)C[C@@]2(O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)C=CC=CC=CC=CC=CC=CC=C[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)C[C@@H]1O2.O=C1CC[C@@H](C(=O)O)N1>>COC(=O)[C@@H]1[C@@H](O)C[C@@]2(O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)C=CC=CC=CC=CC=CC=CC=C[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)C[C@@H]1O2.O=C1CC[C@@H](C(=O)[O-])N1,,O,,,,val
US04705797,COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCl)C1c1cccc([N+](=O)[O-])c1.NCCC(c1ccccc1)c1ccccc1>>COC(=O)C1=C(C)NC(C)=C(C(=O)OCCNCCC(c2ccccc2)c2ccccc2)C1c1cccc([N+](=O)[O-])c1,,Cc1ccccc1C,,CCOCC,,val
US05432049,CC(=O)Cl.Cn1c2ccccc2c(=O)c2c(Oc3ccccc3)ccc(N)c21>>CC(=O)Nc1ccc(Oc2ccccc2)c2c(=O)c3ccccc3n(C)c12,,ClC(Cl)Cl,,c1ccncc1,,val
US20060041146A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc([C@@H](N=[N+]=[N-])C(=O)N2C(=O)OC[C@H]2Cc2ccccc2)cc1C>>COc1ccc([C@@H](NC(=O)OC(C)(C)C)C(=O)N2C(=O)OC[C@H]2Cc2ccccc2)cc1C,[Pd],CCOC(C)=O,,,,val
US04521430,CCCI.CNCCN1C(=O)[C@H](O)[C@H](c2ccc(OC)cc2)Sc2ccccc21>>CCCN(C)CCN1C(=O)[C@H](O)[C@H](c2ccc(OC)cc2)Sc2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05409928,COc1cccc(Cc2ccc(-c3cnn(C(N)=O)c3N)cc2)c1>>COc1cccc(Cc2ccc(-c3c[nH]nc3N)cc2)c1,,CO,,[Na+].[OH-],,val
US20090131482A1,CCI.Oc1cc(F)cc(F)c1>>CCOc1cc(F)cc(F)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US08026257B2,CC(O)c1cc(Cl)cc2cn(COCC[Si](C)(C)C)nc12.N#CC(Cl)(Cl)Cl>>CC(OC(=N)C(Cl)(Cl)Cl)c1cc(Cl)cc2cn(COCC[Si](C)(C)C)nc12,,CCOCC,,C1CCC2=NCCCN2CC1,,val
US20070208018A1,COc1ccc(CNc2cc3c(=O)n(NS(C)(=O)=O)c(=O)[nH]c3cc2[N+](=O)[O-])c(OC)c1>>CS(=O)(=O)Nn1c(=O)[nH]c2cc([N+](=O)[O-])c(N)cc2c1=O,,CCOCC,ClCCl,O=C(O)C(F)(F)F,,val
US20110195977A1,COc1ccc(/C=C/C(=O)O)cc1OC(C)=O.Cn1cncc1Cn1ccc2cccc(N)c21>>COc1ccc(/C=C/C(=O)Nc2cccc3ccn(Cc4cncn4C)c23)cc1O,,C1CCOC1,,O=S(Cl)Cl,,val
US05635477,O=C(NCO)C(Cl)Cl.O=C(O)c1ccc(Cl)cc1>>O=C(O)c1ccc(Cl)c(CNC(=O)C(Cl)Cl)c1,,O=S(=O)(O)O,,,,val
US20030040533A1,CN.COC(=O)C(Cc1ccc(OCCn2c(=O)sc3cc(C(=O)c4ccccc4)ccc32)cc1)C(=O)O>>CNC(=O)C(Cc1ccc(OCCn2c(=O)sc3cc(C(=O)c4ccccc4)ccc32)cc1)C(=O)OC,,ClCCl,,O=S(Cl)Cl,,val
US20100216810A1,N#Cc1cc([N+](=O)[O-])ccc1F.Nc1cc(O)ccc1F>>N#Cc1cc([N+](=O)[O-])ccc1Oc1ccc(F)c(N)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04985419,CC(COS(C)(=O)=O)N1c2ccccc2Sc2ccc(C#N)cc21.CC1CCCNC1>>CC1CCCN(CC(C)N2c3ccccc3Sc3ccc(C#N)cc32)C1,,Cc1ccccc1,,,,val
US20090264437A1,CC(C)(C)c1nc(C2CCC2)cc(N2CCN(CCCCl)CC2)n1.Oc1cc(O)ncn1>>CC(C)(C)c1nc(C2CCC2)cc(N2CCN(CCCOc3cc(O)ncn3)CC2)n1,,CN(C)C=O,,CCN(CC)CC,,val
US20070219183A1,CC(C)(C)OC(=O)NCC(=O)N1CC=C(c2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)n2nccc21>>NCC(=O)N1CC=C(c2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)n2nccc21,,C1COCCO1,ClCCl,Cl,,val
US20120232241A1,Brc1ccccc1I.c1ccc2c(c1)[nH]c1ccncc12>>Brc1ccccc1-n1c2ccccc2c2cnccc21,[Cu],CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040044057A1,NCc1c(O[C@H](Cn2ccnc2)c2ccccc2)ccc2c1CCCC2=O.O=S(=O)(Cl)c1ccccc1>>O=C1CCCc2c1ccc(O[C@H](Cn1ccnc1)c1ccccc1)c2CNS(=O)(=O)c1ccccc1,CN(C)c1ccncc1,c1ccncc1,,Cl,Cl,val
US04808723,CC(N)=S.O=[N+]([O-])c1ccc(Cl)c([N+](=O)[O-])c1>>Cc1nc2cc([N+](=O)[O-])ccc2s1,,O=S1(=O)CCCC1,,O,,val
US20120232047A1,BrCC=CCBr.O=C(NCc1ccccc1)OCc1ccccc1>>O=C(OCc1ccccc1)N(CC=CCBr)Cc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20080234255A1,CCCCN(CCC(=O)OC(C)(C)C)c1nc(Cl)ncc1N>>CCCCN1CCC(=O)Nc2cnc(Cl)nc21,,CC(=O)O,,CCO,,val
US20130137691A1,COC(=O)[C@H]1CC[C@@H](Oc2ccc(C(=O)N(C(=O)c3ccc(O[C@H]4CC[C@@H](C(=O)OC)CC4)cc3)c3ccc(Nc4ccccc4)nn3)cc2)CC1>>COC(=O)[C@@H]1CC[C@H](Oc2ccc(C(=O)Nc3ccc(Nc4ccccc4)nn3)cc2)CC1,,c1ccncc1,,NN,O,val
US20160200708A1,CC(C)(C)OCl.FC(F)c1cc(Cl)ncn1>>FC(F)(Cl)c1cc(Cl)ncn1,,ClC(Cl)(Cl)Cl,,,,val
US04574128,C=CCBr.CN(C)C=NS(=O)(=O)c1cc(C(=O)c2ccc(O)c(Cl)c2Cl)ccc1Cl>>C=CCOc1ccc(C(=O)c2ccc(Cl)c(S(=O)(=O)N=CN(C)C)c2)c(Cl)c1Cl,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060217387A1,NCc1cccnc1.O=S(=O)(Cl)c1ccc(Br)s1>>O=S(=O)(NCc1cccnc1)c1ccc(Br)s1,,C1CCOC1,,CCN(CC)CC,,val
US03953429,CC1([C@H]2CC[C@H]3[C@@H]4CC[C@H]5CC(=O)C(=CO)C[C@]5(C)[C@H]4C(=O)C[C@@]32C)OCCO1>>C[C@@H]1C[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC[C@H](C5(C)OCCO5)[C@@]4(C)CC(=O)[C@@H]32)CC1=O,[Pd],CCOC(C)=O,,,,val
US20100105917A1,N[C@@H]1CCCN(C(=O)c2ccc(Cl)cc2)C1.O=C(Cl)c1ccccc1>>O=C(N[C@@H]1CCCN(C(=O)c2ccc(Cl)cc2)C1)c1ccccc1,,Clc1ccccc1,,[Na+].[OH-],,val
US04863920,O=C1c2c(Cl)cccc2-n2cnc(/C=C\Cl)c2[C@@H]2CCCN12>>C#Cc1ncn2c1[C@@H]1CCCN1C(=O)c1c(Cl)cccc1-2,,CN(C)C=O,,C1CCC2=NCCCN2CC1,O,val
US20080096860A1,CCOC[C@@H](O)CO[Si](C)(C)C(C)(C)C.Fc1cccc(CSc2nc(Cl)cc(Cl)n2)c1F>>CCOC[C@H](CO[Si](C)(C)C(C)(C)C)Oc1cc(Cl)nc(SCc2cccc(F)c2F)n1,,C1CCOC1,,[H-].[Na+],,val
US20120220609A1,CCOC(=O)CNC(=O)c1nc(CC2CCN(c3ccc(Cc4ccc(OCCO[Si](C)(C)C(C)(C)C)nc4)cc3)CC2)nc(C)c1OCc1ccccc1>>CCOC(=O)CNC(=O)c1nc(CC2CCN(c3ccc(Cc4ccc(OCCO)nc4)cc3)CC2)nc(C)c1OCc1ccccc1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20030130506A1,CC(C)(C)[Si](ON)(c1ccccc1)c1ccccc1.O=C(O)C1NCCSC1S(=O)(=O)c1ccc(Oc2ccc(-c3ccoc3)cc2)cc1>>NC(=O)C1NCCSC1S(=O)(=O)c1ccc(Oc2ccc(-c3ccoc3)cc2)cc1,,ClCCl,,ClCCCl,,val
US20080255155A1,CCOC(=O)C(C(=O)OCC)C(Nc1ccc(Oc2cc(NC(=O)N3CCCC3)ncn2)c(F)c1)C(F)(F)F>>O=C(O)CC(Nc1ccc(Oc2cc(NC(=O)N3CCCC3)ncn2)c(F)c1)C(F)(F)F,,CCO,O,[Na+].[OH-],,val
US20140378429A1,CC(C)(C)OC(=O)N1CCC(N)C(C(F)(F)F)C1.COc1ccc(C(=O)C2CCN(C(=O)c3ccc(C(=O)O)cn3)CC2)cc1>>COc1ccc(C(=O)C2CCN(C(=O)c3ccc(C(=O)N[C@H]4CCN(C(=O)OC(C)(C)C)C[C@H]4C(F)(F)F)cn3)CC2)cc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150148349A1,CC(C)(C)OC(=O)N1[C@@H]2C[C@]2(CO)C[C@H]1C(=O)O.CC1(C)CCCC(N)C1>>CC1(C)CCCC(NC(=O)[C@@H]2C[C@@]3(CO)C[C@H]3N2C(=O)OC(C)(C)C)C1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080045514A1,COc1cc(-c2nnc3n2N=C(c2ccc([N+](=O)[O-])cc2)CS3)cc(OC)c1OC>>COc1cc(-c2nnc3n2N=C(c2ccc(N)cc2)CS3)cc(OC)c1OC,[Pd],C1CCOC1,CCO,Cl,[H][H],val
US20080070946A1,C=CCC(OC(=O)[O-])c1nc2cc(N)ccc2s1.CN(C)c1ccc(C(=O)Cl)cc1>>CN(C)c1ccc(C(=O)Nc2ccc3sc(CO)nc3c2)cc1,CN(C)c1ccncc1,CO,ClCCl,CCN(CC)CC,[Na+].[OH-],val
US20090275578A1,COC(=O)c1c(Cl)cc(Br)cc1CBr.COc1ccc(CN)cc1>>COc1ccc(CN2Cc3cc(Br)cc(Cl)c3C2=O)cc1,,CCCCCC,Cc1ccccc1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20130190316A1,Cn1nccc1-c1ncccc1CO.O=S(Cl)Cl>>Cn1nccc1-c1ncccc1CCl,,ClCCl,,,,val
US20070185133A1,BrCCCCBr.CN(C)CCc1cc(-c2nc(NCCN3C(=O)NC(=O)C3(C)C)ncc2Br)sc1Cl>>Clc1sccc1CCN1CCCC1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20130323869A1,NCC(N)c1cccc(Br)c1.O=C1C(=O)c2ccccc2-c2ccccc21>>Brc1cccc(-c2cnc3c4ccccc4c4ccccc4c3n2)c1,,CCO,,[K+].[OH-],,val
US20130331419A1,CCC(c1ccc(Cl)cc1)(c1nn[nH]n1)n1ccc2c(NS(C)(=O)=O)cccc21.CCI>>CCn1nnc(C(CC)(c2ccc(Cl)cc2)n2ccc3c(NS(C)(=O)=O)cccc32)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04666915,CCCCOc1ccccc1N.CCOC(=O)c1cnc(SC)[nH]c1=O>>CCCCOc1ccccc1Nc1ncc(C(=O)OCC)c(=O)[nH]1,,c1ccncc1,,,,val
US06632813B1,CCOC(=O)c1nc2cc(-n3cnc(COC(=O)Nc4ccccc4)c3)c(Cl)cc2[nH]c1=O>>O=C(Nc1ccccc1)OCc1cn(-c2cc3nc(C(=O)O)c(=O)[nH]c3cc2Cl)cn1,,CCO,,O,[Li+].[OH-],val
US20100063120A1,CNC(C(=O)OC)c1cccc(OC)c1.O=C=Nc1ccc(Cl)c(Cl)c1>>COc1cccc(C2C(=O)N(c3ccc(Cl)c(Cl)c3)C(=O)N2C)c1,,C1CCOC1,,,,val
US07132428B2,Cc1n[nH]c(-c2ccccc2)c1N.O=C(Cl)c1ccco1>>Cc1n[nH]c(-c2ccccc2)c1NC(=O)c1ccco1,,ClCCl,,CCN(CC)CC,,val
US08487121B2,CC(C)Oc1c(CCC(=O)O)cccc1NS(C)(=O)=O.CC1(C)CC(N)c2ccccc2O1.CCN(CC)CC.Cl>>CC(C)Oc1c(CCC(=O)NC2CC3(CCC3)Oc3ccc(Cl)cc32)cccc1NS(C)(=O)=O,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20110201604A1,CCN(CC)c1cc(NC)c([N+](=O)[O-])cc1C(=O)OC>>CCN(CC)c1cc(NC)c(N)cc1C(=O)OC,[Pd],,,,,val
US20100029753A1,COCN(c1ccsc1C(=O)OC)S(=O)(=O)c1ccc(C(C)(C)C)cc1-c1ccncc1Cl>>COC(=O)c1sccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1-c1ccncc1Cl,,C1CCOC1,,Cl,,val
US20120214791A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.FC(F)c1ccc(Br)cc1>>CC1(C)OB(c2ccc(C(F)F)cc2)OC1(C)C,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20050032787A1,COC(=O)C(=Cc1ccc(OCCO)cc1)C(=O)OC>>COC(=O)C(Cc1ccc(OCCO)cc1)C(=O)OC,[Pd],CO,,,,val
US05726306,COc1ccccc1C(=O)c1cc(Cl)ccc1NC(C)=O>>Nc1ccc(Cl)cc1C(=O)c1ccccc1O,,Br,,[Na+].[OH-],,val
US05801249,C[C@H](NC(=O)C(Cl)(Cl)Cl)C(C)(C)O>>C[C@@H]1NC(=O)OC1(C)C,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20020156081A1,Nc1ncnc2c1c(Br)nn2C1CCN(Cc2ccccc2)CC1.OB(O)c1ccc(Oc2ccccc2)cc1>>Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(Cc2ccccc2)CC1,,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US04263319,O=C1CCc2c1cccc2-c1ccccc1>>OC1CCc2c(-c3ccccc3)cccc21,,CCO,O,[BH4-].[Na+],,val
US04521607,CC(=O)SCC(C)C(=O)Cl.CCOC(=O)CNC1CCc2c(OC)cccc21>>CCOC(=O)CN(C(=O)C(C)CSC(C)=O)C1CCc2c(OC)cccc21,,CC(=O)N(C)C,,O,,val
US20070129355A1,COC(=O)Cc1cnc(Cc2ccc(NC(=O)Oc3ccccc3)cc2)nc1N(C)C.OCc1ccc(F)cc1>>COC(=O)Cc1cnc(Cc2ccc(NC(=O)OCc3ccc(F)cc3)cc2)nc1N(C)C,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20090023725A1,Brc1ccc2c(-c3ccc(N4CCOCC4)nc3)n[nH]c2c1.CCNC(=O)c1ccc(C)c(B2OC(C)(C)C(C)(C)O2)c1>>CCNC(=O)c1ccc(C)c(-c2ccc3c(-c4ccc(N5CCOCC5)nc4)n[nH]c3c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(C)O,,O=C([O-])O.[Na+],,val
US20060040978A1,Cl.NCCCCN1CCc2ccccc2C1.O=S(=O)(Cl)c1cccc2ccccc12>>Cl.O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2ccccc12,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20160211463A1,Fc1cc(Br)c2nsnc2c1Br>>Nc1c(Br)cc(F)c(Br)c1N,,CCO,,,,val
US20050182103A1,N#Cc1cc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)[nH]c1=O.O=C1c2ccccc2C(=O)N1CCBr>>N#Cc1cc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)nc1OCCN1C(=O)c2ccccc2C1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06323235B1,COc1cccc2cc(CCl)oc12.OCCC(c1ccccc1)c1ccccc1>>COc1cccc2cc(COCCC(c3ccccc3)c3ccccc3)oc12,,CN(C)C=O,O,[H-].[Na+],[Cl-].[NH4+],val
US05491167,CC(Oc1ccccc1C(C)C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O3)[C@H]21>>CC(Oc1ccccc1C(C)C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050107377A1,Fc1ccc2c(N3CCNCC3)n[nH]c2c1.c1cc(OC[C@H]2CO2)cc(-c2noc3ncccc23)c1>>O[C@@H](COc1cccc(-c2noc3ncccc23)c1)CN1CCN(c2n[nH]c3cc(F)ccc23)CC1,,CCO,CN(C)C=O,,,val
US20120129840A1,CCCI.COC(=O)Cc1c(C)nc(Cl)nc1-c1ccccc1>>CCCC(C(=O)OC)c1c(C)nc(Cl)nc1-c1ccccc1,,CN(C)C=O,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100069381A1,COc1ccc(CCl)cc1F.NNC(=O)c1ccc2c(c1)CCO2.S=C=S>>COc1ccc(CSc2nnc(-c3ccc4c(c3)CCO4)o2)cc1F,,CCO,CCOC(C)=O,[K+].[OH-],,val
US20160214997A1,COc1ccc(CNc2nc3c4c(ccc3c3nc(CCO)nn23)OC(F)(F)O4)c(OC)c1.CS(=O)(=O)Cl>>COc1ccc(CNc2nc3c4c(ccc3c3nc(CCOS(C)(=O)=O)nn23)OC(F)(F)O4)c(OC)c1,,ClCCl,,CCN(CC)CC,,val
US20050038095A1,CI.COc1cc(C(=O)NC2CC(C)(C)N(C)C(C)(C)C2)ccc1-c1nc2cc(Cl)c(Cl)cc2[nH]1>>COc1cc(C(=O)NC2CC(C)(C)N(C)C(C)(C)C2)ccc1-c1nc2cc(Cl)c(Cl)cc2n1C,,CC(C)=O,,[K+].[OH-],,val
US20140315917A1,O=C(Cl)Cl.O=C1NCCN1C1CCOCC1>>O=C(Cl)N1CCN(C2CCOCC2)C1=O,,ClCCl,,c1ccncc1,,val
US20120220565A1,C1CCNC1.CCOC[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(Cl)nc1)C2>>CCOC[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(N3CCCC3)nc1)C2,,CC#N,,,,val
US20110190302A1,CC(=O)OCC(O)c1cccc([N+](=O)[O-])c1>>O=[N+]([O-])c1cccc(C(O)CO)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20050176775A1,Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1Cc1ccc(C(=O)O)o1>>Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1Cc1ccc(CO)o1,,C1CCOC1,,B,CSC,val
US20070105904A1,Cc1ccnc(F)c1.OCc1ccc(Br)cc1>>Cc1ccnc(OCc2ccc(Br)cc2)c1,,O,,CN(C)C=O,[H-].[Na+],val
US06992187B2,CCOC(=O)[C@H](CN)NS(=O)(=O)c1cccc2ccccc12.O=[N+]([O-])c1c(Cl)ncnc1Cl>>CCOC(=O)[C@H](CNc1ncnc(Cl)c1[N+](=O)[O-])NS(=O)(=O)c1cccc2ccccc12,,CCOC(C)=O,,C1CCOC1,CCN(CC)CC,val
US20060252750A1,Cc1ccc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCN(C(=O)OC(C)(C)C)CC3)CC2)cc1Cl>>Cc1ccc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCNCC3)CC2)cc1Cl,,CO,,Cl,,val
US20120258968A1,Clc1cc(Cl)ncn1.Nc1cccc(Cn2ccc3ccccc32)c1>>Clc1cc(Nc2cccc(Cn3ccc4ccccc43)c2)ncn1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20160108047A1,CC(C)n1c(Br)nc2c1C(c1ccc(Cl)cc1)N(c1ccc(=O)n(C)c1)C2=O.CCCC[Sn](CCCC)(CCCC)c1ccccn1>>CC(C)n1c(-c2ccccn2)nc2c1C(c1ccc(Cl)cc1)N(c1ccc(=O)n(C)c1)C2=O,,CC(=O)N(C)C,,[Cs+].[F-],,val
US20110144105A1,CC(C)Br.CS(=O)(=O)c1ccc(C(=CC2CCCC2)c2cc3cc(O)cnc3n2S(=O)(=O)c2ccccc2)cc1>>CC(C)Oc1cnc2c(c1)cc(C(=CC1CCCC1)c1ccc(S(C)(=O)=O)cc1)n2S(=O)(=O)c1ccccc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20090137637A1,Ic1cccc(-c2nn[nH]n2)c1.OCCCBr>>OCCCn1nnc(-c2cccc(I)c2)n1,,CC#N,,CCN(CC)CC,,val
US20150005286A1,CC(C)(C)OC(=O)N1CC[C@@H](C(F)F)C1.Cl>>Cl.FC(F)[C@@H]1CCNC1,,C1COCCO1,,,,val
US09199927B2,CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)Nc1ccc(C(=O)Oc2ccc(CC(=O)N[C@@H](Cc3ccc(OC(C)(C)C)cc3)C(=O)OC(C)(C)C)c(Cl)c2)cc1.Cl>>Cl.N=C(N)Nc1ccc(C(=O)Oc2ccc(CC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)O)c(Cl)c2)cc1,,C1COCCO1,,,,val
US04843087,Cc1noc(CCCCCCCOc2ccc(C3=NCCO3)cc2)c1CO.O=S(Cl)Cl>>Cc1noc(CCCCCCCOc2ccc(C3=NCCO3)cc2)c1CCl,,ClCCl,,,,val
US20080182891A1,Cc1ccc(S(=O)(=O)OC[C@H]2CCCc3cc(F)cc(-c4c(Cl)cccc4Cl)c3O2)cc1.[N-]=[N+]=[N-]>>[N-]=[N+]=NC[C@H]1CCCc2cc(F)cc(-c3c(Cl)cccc3Cl)c2O1,,CN(C)C=O,,CCOC(C)=O,,val
US05665754,COC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1c1ccc(OC)c(OC2CCCC2)c1.C[Si](C)(C)N=C=O>>COC(=O)[C@@H]1CN(C(N)=O)C[C@H]1c1ccc(OC)c(OC2CCCC2)c1,CN(C)c1ccncc1,ClCCl,,O=C(O)C(F)(F)F,,val
US20080255086A1,CN.O=Cc1cn(CC(=O)Nc2sc3c(c2C(=O)NCCO)CCCC3)nc1C(F)(F)F>>CNCc1cn(CC(=O)Nc2sc3c(c2C(=O)NCCO)CCCC3)nc1C(F)(F)F,[Pd],ClCCl,,CC(=O)O,[H][H],val
US20150133510A1,NCc1ccncc1.O=Cc1ccc(F)cc1>>Fc1ccc(CNCc2ccncc2)cc1,,CO,,[BH3-]C#N.[Na+],,val
US20130210801A1,Cc1cc2nc(OS(=O)(=O)C(F)(F)F)ccc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C.c1c[nH]cn1>>Cc1cc2nc(-n3ccnc3)ccc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C,,COCCOC,,,,val
US04346030,O=C1c2ccccc2-n2cnc(C=NO)c2[C@@H]2CCCN12>>N#Cc1ncn2c1[C@@H]1CCCN1C(=O)c1ccccc1-2,,CC(=O)OC(C)=O,,,,val
US20060019944A1,O=C1c2ccccc2C(=O)N1[C@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1>>N[C@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1,,Cc1ccccc1,,NN,,val
US20090156612A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2ncn(C3CCCCC3=O)c2-c2ccccc2)[C@H](Cc2ccccc2)C1.C[Si](C)(C)C(F)(F)F>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ncn(C3CCCCC3(O)C(F)(F)F)c2-c2ccccc2)[C@H](Cc2ccccc2)C1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150322045A1,CC(C)c1cnccn1>>CC(C)C1CNCCN1,[Pd],CCO,,,,val
US20130172384A1,O=C(C1CC1)N1CC[C@@H](Cn2c(-c3ccc(Br)cc3F)n[nH]c2=O)C1.OB(O)c1ccc2cc[nH]c2c1>>O=C(C1CC1)N1CC[C@@H](Cn2c(-c3ccc(-c4ccc5cc[nH]c5c4)cc3F)n[nH]c2=O)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US20150065499A1,COC(=O)C1=C(N)c2cnc3cc(OC)c(OC)cc3c2S1=O.COC(OC)N(C)C>>COC(=O)c1sc2c(cnc3cc(OC)c(OC)cc32)c1/N=C/N(C)C,,CN(C)C=O,,,,val
US06093732,CCOC(=O)c1cnc2c(O)cccc2c1O.NCc1ccc(Cl)cc1>>O=C(NCc1ccc(Cl)cc1)c1cnc2c(O)cccc2c1O,,ClCCl,,,,val
US20130237537A1,Nc1ccccc1.Nc1ncc2c(n1)CCN(c1cccc(C(=O)O)c1)C2>>Nc1ncc2c(n1)CCN(c1cccc(C(=O)Nc3ccccc3)c1)C2,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04160765,CCCCBr.COc1cc2c(c(Cl)c1OC)CCNCC2c1ccccc1>>CCCCN1CCc2c(cc(OC)c(OC)c2Cl)C(c2ccccc2)C1,,CO,,[K+].[OH-],,val
US20060276498A1,N#Cc1cnc2cnc(F)cc2c1Nc1ccc(F)c(Cl)c1.OCCN1CCOCC1>>N#Cc1cnc2cnc(OCCN3CCOCC3)cc2c1Nc1ccc(F)c(Cl)c1,,C1CCOC1,,,,val
US20020119992A1,O=C(O)C1(O)c2ccccc2-c2ccccc21.O=C(OCc1ccccc1)[C@@H]1CCCN1>>O=C(OCc1ccccc1)[C@@H]1CCCN1C(=O)C1(O)c2ccccc2-c2ccccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US04898694,C[C@]12CC[C@H]3[C@@H](C=C[C@@]4(OO)C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O.C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](OCc5ccccc5)CC[C@@]43C)[C@@H]1CCC2=O>>C[C@H]1CC[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]32)C1,[Pd],CC(=O)O,,[H][H],,val
US20160130266A1,C1CSCN1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1(C(=O)OCc2ccccc2)CCCCC1>>O=C(NC1(C(=O)OCc2ccccc2)CCCCC1)N1CCSC1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US04288436,CCOC(=O)C(=NOC)C(=O)CCl.SCCS>>CCOC(=O)C(=NOC)C1=CSCCS1,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US20140134133A1,COc1ncc(-c2ccc3ncc(C#C[Si](C)(C)C)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1>>C#Cc1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4)c3)nn12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04593029,CCCCBr.O=C1CN2Cc3cc(OCCCCCCn4ccnc4)ccc3N=C2N1>>CCCCN1C(=O)CN2Cc3cc(OCCCCCCn4ccnc4)ccc3N=C21,,CN(C)C=O,,[H-].[Na+],,val
US20080293749A1,C[Si](C)(C)Cl.O=C1CC(N2C=Nc3cc(F)ccc3C2)C(=O)N1>>Cl.O=C1CC(N2C=Nc3cc(F)ccc3C2)C(=O)N1,,CCC(C)=O,,O,,val
US20060040965A1,C=CCNS(=O)(=O)c1ccc(-c2[nH]c3ncnc(NCC4CCCO4)c3c2-c2ccccc2)cc1.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>O=S(=O)(NCC(O)CO)c1ccc(-c2[nH]c3ncnc(NCC4CCCO4)c3c2-c2ccccc2)cc1,O=[Os](=O)(=O)=O,CC(C)(C)O,O,CC(C)=O,,val
US20160237067A1,Cc1ccc(S(=O)(=O)N2CCOCC2)cc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1.Cl>>Cc1ccc(S(=O)(=O)N2CCOCC2)cc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1.Cl,,C1COCCO1,ClCCl,CC#N,,val
US20120059014A1,CC(C)c1noc(N2CCC([C@H](C)CCOc3cnc(Cl)nc3)CC2)n1.CC1CCC(=O)N([C@H]2CNC[C@@H]2NC(=O)OC(C)(C)C)C1>>CC1CCC(=O)N([C@H]2CN(c3ncc(OCC[C@@H](C)C4CCN(c5nc(C(C)C)no5)CC4)cn3)C[C@@H]2NC(=O)OC(C)(C)C)C1,,CS(C)=O,,C1CCC2=NCCCN2CC1,,val
US20080312207A1,CCOC(=O)c1ccc(Oc2cc(OC(C)C)cc(C(=O)Nc3nc(C)ns3)c2)cc1>>Cc1nsc(NC(=O)c2cc(Oc3ccc(C(=O)O)cc3)cc(OC(C)C)c2)n1,,C1CCOC1,O,[Li+].[OH-],,val
US04772600,C1CCNCC1.COc1ccc(-c2nc3cccnc3n2CC(=O)O)cc1>>COc1ccc(-c2nc3cccnc3n2CC(=O)N2CCCCC2)cc1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20070117840A1,CC(C)(C)Cn1c(C(=O)OC(C)(C)C)c(O)c2cc(Cl)c(Cl)cc2c1=O.CCOC(=O)CBr>>CCOC(=O)COc1c(C(=O)OC(C)(C)C)n(CC(C)(C)C)c(=O)c2cc(Cl)c(Cl)cc12,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090111789A1,CCOc1cc(C(C)(C)C)ncc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1C(=O)Cl.CS(=O)(=O)CCCN1CCNCC1>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCN(CCCS(C)(=O)=O)CC1,,ClCCl,,CCN(CC)CC,,val
US20070197553A1,COC(=O)c1csc(N)n1.Cc1cc(-c2cc(F)cc(F)c2)nc(C(=O)O)n1.ClCCl>>COC(=O)c1csc(NC(=O)c2cc(-c3cc(F)cc(F)c3)cc(C)n2)n1,,CC(=O)N(C)C,ClCCl,CCN(C(C)C)C(C)C,,val
US20160137696A1,COCCOCCOCCOCCOS(=O)(=O)c1ccc(C)cc1.[N-]=[N+]=[N-]>>COCCOCCOCCOCCN=[N+]=[N-],,CCO,,O,,val
US20120040981A1,CC1(C)OB(c2ccnc3[nH]ccc23)OC1(C)C.CN1c2cc(Br)sc2C(=O)NC1(C)C>>CN1c2cc(-c3ccnc4[nH]ccc34)sc2C(=O)NC1(C)C,,O,,COCCOC,O=C([O-])[O-].[Cs+].[Cs+],val
US20090069419A1,CC(C)(CO[Si](C)(C)C(C)(C)C)C(=O)O.OCCN1CCOCC1>>CC(C)(CO[Si](C)(C)C(C)(C)C)C(=O)OCCN1CCOCC1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US06630472B1,NCCCCc1ccccc1.O=C(O)C1CCCC(C(=O)O)N1C(=O)OCc1ccccc1>>O=C1C2CCCC(C(=O)N1CCCCc1ccccc1)N2C(=O)OCc1ccccc1,,C1COCCO1,,CC(=O)OC(C)=O,,val
US20110152240A1,Cc1c(Nc2ccc(C#N)cc2Cl)nc2c(C=O)cnn2c1NC1CC1.O=C1CNC(=O)N1>>Cc1c(Nc2ccc(C#N)cc2Cl)nc2c(C=C3NC(=O)NC3=O)cnn2c1NC1CC1,,CCO,O,C1CCNCC1,,val
US20120217868A1,CC(=O)c1cc(C)cc(C)c1.Nc1ccc(Br)cc1CO>>Cc1cc(C)cc(-c2ccc3cc(Br)ccc3n2)c1,,Cc1ccccc1,,[K+].[OH-],,val
US09284307B2,C=CCCCCN(C)C(=O)[C@@H]1CC[C@@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C[C@H]1C(=O)N[C@]1(C(=O)OC)C[C@H]1C=C>>COC(=O)[C@@]12C[C@H]1C=CCCCCN(C)C(=O)[C@@H]1CC[C@@H](O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)C[C@H]1C(=O)N2,,CC(Cl)Cl,,,,val
US04045469,CC(C)=C1C=CC=C1.CCOC(=O)CCl>>CCOC(=O)C1C(C)(C)C12C=CC=C2,,ClC(Cl)(Cl)Cl,,CC(C)(C)O,CC(C)(C)[O-].[K+],val
US05336778,CCCCC(=N)OCC.NNC(=O)c1ccncc1>>CCCCC(=NNC(=O)c1ccncc1)OCC,,CCO,,Cl,,val
US20080045521A1,CN(C(=O)OC(C)(C)C)c1cccc(CCCc2ccc(C[C@H](N)C(=O)OC(C)(C)C)cn2)n1.O=C(Cl)c1c(Cl)cccc1Cl>>CN(C(=O)OC(C)(C)C)c1cccc(CCCc2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)OC(C)(C)C)cn2)n1,,ClCCl,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US20140187533A1,CC(C)(C)OC(=O)N1CCN(CC(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2N)C(=O)C1>>CC(C)(C)OC(=O)N1CCN(Cc2nc3c(C(F)(F)F)cc(C(F)(F)F)cc3[nH]2)C(=O)C1,,C1CCOC1,CC(=O)O,,,val
US06593355B2,CCOC(=O)CBr.Cn1c(CNc2ccc(C#N)cc2)nc2cc(C(C)(CN)C(=O)N3CCCC3)ccc21>>CCOC(=O)CNCC(C)(C(=O)N1CCCC1)c1ccc2c(c1)nc(CNc1ccc(C#N)cc1)n2C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120053053A1,CC#C[Sn](CCCC)(CCCC)CCCC.COC(=O)c1nc(Cl)nc(N)c1I>>CC#Cc1c(N)nc(Cl)nc1C(=O)OC,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,CCOC(C)=O,,val
US05654298,CCOc1cc(N(CC)c2ccccc2)cc(C)n1.Cl.NCCO>>CCN(c1ccccc1)c1cc(C)nc(NCCO)c1.Cl,,CCOC(C)=O,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20070259965A1,CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)NC[C@@H](O)CNS(=O)(=O)c1ccc(Cl)cc1Cl>>CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)NCC(=O)CNS(=O)(=O)c1ccc(Cl)cc1Cl,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20130012721A1,O=C1N2CN3C(=O)N4CN5C(=O)N6CN7C(=O)N8CN9C(=O)N%10CN%11C(=O)N%12CN%13C(=O)N%14CN%15C(=O)N%16CN1C1C2N2CN%17C(=O)N(CN%18C(=O)N(CN%19C(=O)N(CN%20C(=O)N(CN%21C(=O)N(CN%22C(=O)N(CN%23C(=O)N(CN1C2=O)C%16C%15%23)C%14C%13%22)C%12C%11%21)C%10C9%20)C8C7%19)C6C5%18)C4C3%17>>O=C1N2CN3C(=O)N4CN5C(=O)N6CN7C(=O)N8CN9C(=O)N%10CN%11C(=O)N%12CN1C1C2N2CN%13C(=O)N(CN%14C(=O)N(CN%15C(=O)N(CN%16C(=O)N(CN%17C(=O)N(CN1C2=O)C%12C%11%17)C%10C9%16)C8C7%15)C6C5%14)C4C3%13,,O,,,,val
US20100048543A1,NCC1COCCO1.Nc1ncnc(N)c1C#Cc1cccc(NC(=O)Oc2ccccc2)c1>>Nc1ncnc(N)c1C#Cc1cccc(NC(=O)NCC2COCCO2)c1,,C1CCOC1,,CCN(CC)CC,,val
US20130240784A1,CCCC1CCC(CCc2ccc(Br)cc2F)CC1.CN(C)C=O>>CCCC1CCC(CCc2ccc(Br)c(C=O)c2F)CC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20050277717A1,CCCCCCCC(=O)Cl.CCO[Si](CCCS)(OCC)OCC>>CCCCCCCC(=O)SCCC[Si](OCC)(OCC)OCC,,CCCCCC,,CCN(CC)CC,N#N,val
US20050261327A1,Cc1ccnc(Cl)c1[N+](=O)[O-].NCC1CCC2(CC1)OC=Cc1ccccc12>>Cc1ccnc(NCC2CCC3(CC2)OC=Cc2ccccc23)c1[N+](=O)[O-],,C1CCOC1,,CCN(CC)CC,,val
US20150282482A1,COC(=O)c1cc2c(C#N)cccc2s1.O.[OH-]>>O=C(O)c1cc2c(C(=O)O)cccc2s1,,CO,,Cl,,val
US20020161237A1,COC(=O)/C(=C/c1nccs1)NC(=O)c1ccc(C(=O)NCc2cccc(O)c2)cc1Br>>O=C(O)/C(=C/c1nccs1)NC(=O)c1ccc(C(=O)NCc2cccc(O)c2)cc1Br,,C1CCOC1,CO,[Na+].[OH-],,val
US20120053147A1,COCCC(=O)Cl.Cc1c(Cl)cccc1CNc1nc(N2CCOCC2)sc1C(N)=O>>COCCc1nc(=O)c2sc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1C,,COCCOC,,Cl,[Na+].[OH-],val
US20030166639A1,CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccncc3)c2)cc1C(F)(F)F>>CN(C)c1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3ccncc3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070066617A1,C=C(Br)C(F)(F)F.OB(O)Oc1cc(Cl)cc(Cl)c1>>C=C(c1cc(Cl)cc(Cl)c1)C(F)(F)F,,C1CCOC1,O,O=C([O-])[O-].[K+].[K+],,val
US20080275043A1,BrP(Br)Br.OCc1c(Cl)ccc(Br)c1F>>Fc1c(Br)ccc(Cl)c1CBr,,ClCCl,,O,,val
US20110178120A1,COC(=O)c1ncc(NC(=O)c2ccc(F)cc2)c2c1OC(C)(C)OC2>>COC(=O)c1ncc(NC(=O)c2ccc(F)cc2)c(CO)c1O,,O=CO,,,,val
US20160009667A1,CCCc1cc2c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)noc2cc1COc1ccc(Cl)c(Cl)c1>>CCCc1cc2c(N)noc2cc1COc1ccc(Cl)c(Cl)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050234244A1,COc1cc2c(CC(=O)OCC[Si](C)(C)C)c(C)n(C(=O)c3ccc(Cl)cc3)c2cc1F>>Cc1c(CC(=O)O)c2cc(O)c(F)cc2n1C(=O)c1ccc(Cl)cc1,,ClCCl,,BrB(Br)Br,,val
US20130079321A1,Cn1ncc([N+](=O)[O-])c1N1CCCC(C)(O)CC1>>Cn1ncc(N)c1N1CCCC(C)(O)CC1,[Pd],CO,,O=C[O-].[NH4+],,val
US04152452,Nc1ccccc1.O=Cc1ccccc1>>C(=Nc1ccccc1)c1ccccc1,,CCO,,,,val
US20140179667A1,Cc1cc(C)c(CCl)c(OCc2ccccc2)n1.Cc1nnn(C)c1-c1cc(Br)c2c(c1Cl)C(=O)NCC2>>Cc1cc(C)c(CN2CCc3c(Br)cc(-c4c(C)nnn4C)c(Cl)c3C2=O)c(OCc2ccccc2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20060287522A1,NCc1ccccc1.O=C(NCc1cccnc1)c1ccc2n1Cc1ccccc1N(C(=O)c1ccc(Cl)nc1)C2>>O=C(NCc1cccnc1)c1ccc2n1Cc1ccccc1N(C(=O)c1ccc(NCc3ccccc3)nc1)C2,,ClCCl,,,,val
US20050131022A1,O=[N+]([O-])c1ccc(F)cc1N1CCCCC1.c1cn[nH]c1>>O=[N+]([O-])c1ccc(-n2cccn2)cc1N1CCCCC1,,CS(C)=O,,[Na+].[OH-],,val
US20030036557A1,CS(=O)(=O)c1ccc(NC(=N)c2ccccn2)cc1.O=C(CBr)C(F)(F)F>>CS(=O)(=O)c1ccc(N2CC(O)(C(F)(F)F)N=C2c2ccccn2)cc1,,CC(C)O,,O=C([O-])O.[Na+],,val
US20060160821A1,CN1CCCN(c2ccc(N)cc2)CC1.Cc1ccccc1C(NC(=O)Nc1ccc(Cl)cc1)C(=O)Nc1ccc(C2=NCCN2C)cc1>>Cc1ccccc1C(NC(=O)Nc1ccc(Cl)cc1)C(=O)Nc1ccc(N2CCCN(C)CC2)cc1,,CN(C)C=O,O,ClCCCl,,val
US20120184546A1,COc1cc(Cc2nc3ccccc3c3nc(N)nn23)cc(OC)c1>>Nc1nc2c3ccccc3nc(Cc3cc(O)cc(O)c3)n2n1,,ClCCl,ClCCl,BrB(Br)Br,,val
US06184225B2,COCCOc1cc2ncnc(Nc3cc(OC(C)=O)c(Cl)cc3F)c2cc1OC>>COCCOc1cc2ncnc(Nc3cc(O)c(Cl)cc3F)c2cc1OC,,CO,O,N,,val
US20070173526A1,CC[C@H]1C[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(C)=O)c2nc(Br)ccc2N1C(=O)OC(C)C.CNC>>CC[C@H]1C[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(C)=O)c2nc(N(C)C)ccc2N1C(=O)OC(C)C,,CS(C)=O,O,,,val
US20040122039A1,BrCC1CC1.COc1cc(C)cc(C)c1-c1cccc2c(NC(=O)OC(C)(C)C)c(SC)nn12>>COc1cc(C)cc(C)c1-c1cccc2c(N(CC3CC3)C(=O)OC(C)(C)C)c(SC)nn12,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20120035214A1,CC(=O)NCCc1ccccc1-c1onc([C@H]2CN(C(=O)OC(C)(C)C)CC[C@@H]2c2ccc(F)c(F)c2)c1Br>>CC(=O)NCCc1ccccc1-c1onc([C@H]2CNCC[C@@H]2c2ccc(F)c(F)c2)c1Br,,ClCCl,,C1COCCO1,Cl,val
US06057451,Nc1nc(-c2ccc(CCNC(=O)C(F)(F)F)cc2)cs1>>NCCc1ccc(-c2csc(N)n2)cc1,,CO,O,Br,[Na+].[OH-],val
US20080269192A1,CC(C)(C)[Si](C)(C)OC[C@H](Cc1ccc(O[Si](C)(C)C(C)(C)C)cc1)Nc1c([N+](=O)[O-])cnc2ccccc12>>CC(C)(C)[Si](C)(C)OC[C@H](Cc1ccc(O[Si](C)(C)C(C)(C)C)cc1)Nc1c(N)cnc2ccccc12,[Pt],Cc1ccccc1,,,,val
US06518260B1,BrB(Br)Br.C[C@H](NC(=O)C(Cc1ccccc1)CP(=O)(O)C(Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)O>>Br.C[C@H](NC(=O)C(Cc1ccccc1)CP(=O)(O)C(N)Cc1ccccc1)C(=O)O,,ClCCl,,O,,val
US20070066617A1,CC(=O)OC(C)=O.Nc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)NCC(F)(F)F>>CC(=O)Nc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)NCC(F)(F)F,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20080242655A1,CCOC(=O)c1c(Nc2ccc([Si](C)(C)C)cc2F)c2cncc(Cl)c2n1C.ClI>>CCOC(=O)c1c(Nc2ccc(I)cc2F)c2cncc(Cl)c2n1C,,ClCCl,,,,val
US20100144741A1,CC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)[C@H]1CN(C2(c3cccc(C(C)C)c3)CC2)C(=O)O1>>CC(=O)N[C@@H](Cc1ccc(N)cc1)[C@H]1CN(C2(c3cccc(C(C)C)c3)CC2)C(=O)O1,Cl[Ni]Cl,CO,,O,[BH4-].[Na+],val
US20100029753A1,COC(=O)c1sccc1N(C)S(=O)(=O)c1ccc(C(C)(C)C)cc1>>CN(c1ccsc1C(=O)O)S(=O)(=O)c1ccc(C(C)(C)C)cc1,,C1COCCO1,O,[Na+].[OH-],,val
US20020103229A1,CCCC[Sn](CCCC)(CCCC)N=[N+]=[N-].CN(C)CCCOc1cccc(-c2n[nH]c3ccc(C#N)cc23)c1>>CN(C)CCCOc1cccc(-c2n[nH]c3ccc(-c4nnn[nH]4)cc23)c1,,Cc1ccccc1,,Cl,O=C(O)C(F)(F)F,val
US20050234041A1,COc1ccc2c(c1)C(=NO)CCC2.O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3>>COc1ccc2c(c1)NC(=O)CCC2,,CS(=O)(=O)O,,,,val
US04837003,N#CCCCCCCN(CCN1C(=O)c2ccccc2C1=O)CCN1C(=O)c2ccccc2C1=O>>N#CCCCCCCN(CCN)CCN,,CO,,NN,,val
US20030045532A1,BrCC1CC1.CC(C)(C)OC(=O)N1CCNC(=O)C1>>CC(C)(C)OC(=O)N1CCN(CC2CC2)C(=O)C1,,CC(=O)N(C)C,O,[H-].[Na+],,val
US20050176775A1,BrC(Br)(Br)Br.COC(=O)c1ccc(C)c(-n2c(C)cc(CO)cc2=O)c1>>COC(=O)c1ccc(C)c(-n2c(C)cc(CBr)cc2=O)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060235030A1,CSc1nc(-c2cc(NC(=O)c3ccsc3)ccc2C)c2c(n1)N(c1c(F)cccc1F)C(=O)NC2.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(NC(=O)c2ccsc2)cc1-c1nc(S(C)=O)nc2c1CNC(=O)N2c1c(F)cccc1F,,CN(C)C=O,ClCCl,,,val
US20100190981A1,CC(C)(C)C(=O)OCn1ccc2c(-c3cn[nH]c3)ncnc21.N#CC=CC1CCCC1>>CC(C)(C)C(=O)OCn1ccc2c(-c3cnn(C(CC#N)C4CCCC4)c3)ncnc21,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20120264923A1,CC(=CCCOS(=O)(=O)c1ccc(C)cc1)CCCC(C)CCCC(C)CCCC(C)C.O=C1O[C@H]([C@@H](O)CO)C(O)=C1O>>CC(=CCCOC1=C(O)[C@@H]([C@@H](O)CO)OC1=O)CCCC(C)CCCC(C)CCCC(C)C,,CC#N,,CCN(CC)CC,,val
US20160168100A1,CCn1cc(/C=C/C(=O)O)cn1.COc1ccc(CCN)cc1OCc1ccccc1>>CCn1cc(/C=C/C(=O)NCCc2ccc(OC)c(OCc3ccccc3)c2)cn1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120264737A1,CC(C)(C)OC(=O)N1CC=C(c2ccc(C#N)cc2)CC1>>CC(C)(C)OC(=O)N1CCC(c2ccc(C#N)cc2)CC1,,CCOC(C)=O,,,,val
US05037834,Cl.NC(N)=S.O=C(CBr)CCN1C(=O)c2ccccc2C1=O>>Cl.Nc1nc(CCN2C(=O)c3ccccc3C2=O)cs1,,CCCO,,,,val
US20130131036A1,Brc1ccccn1.C1CCOC1.CC(C)(C)OC(=O)N1CCC(C#N)(c2ccc(Cl)c(Cl)c2)CC1>>CC(C)(C)OC(=O)N1CCCCC1C(=O)C1(c2ccc(Cl)c(Cl)c2)C=CNC=C1,,[Cl-],[NH4+],[Li]CCCC,,val
US06166056,C1CCOC1.O.[N-]=[N+]=NC[C@@H]1CN(c2ccc(C3CN(C(=O)OCc4ccccc4)C3)c(F)c2)C(=O)O1>>CC(=O)NC[C@H]1CN(c2ccc(C3CN(C(=O)OCc4ccccc4)C3)c(F)c2)C(=O)O1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130317218A1,CC(C)(C)OC(=O)N1CCN(Cc2ccc(C(=O)Nc3sc(Nc4ccc5ccccc5c4)nc3C(N)=O)cc2)CC1>>NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CCNCC2)cc1,,C1COCCO1,Cl,,,val
US20160109417A1,C=Cc1ccccc1C.C=Cc1ccccc1C=C>>C=Cc1ccccc1C.C=Cc1ccccc1C=C,,Cc1ccccc1,,O,,val
US20120101134A1,CCc1c(CCN(C)CC(=O)OC)cccc1-c1cnc(-c2ccc(OC(C)C)c(Cl)c2)s1>>CCc1c(CCN(C)CC(=O)O)cccc1-c1cnc(-c2ccc(OC(C)C)c(Cl)c2)s1,,CC(C)O,O,[Na+].[OH-],,val
US20110195948A1,Cn1nc(C(=O)O)ccc1=O.Nc1cnn2ccc(N3CCC[C@@H]3c3cccc(F)c3)nc12>>Cn1nc(C(=O)Nc2cnn3ccc(N4CCC[C@@H]4c4cccc(F)c4)nc23)ccc1=O,,CCOCC,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06407129B1,O=C(OCCl)OCCCOCc1ccccc1.[I-]>>O=C(OCI)OCCCOCc1ccccc1,,CC#N,,O,,val
US20050250810A1,C=CC(=O)Cl.CNCc1c(C)c2ccccc2n1C>>C=CC(=O)N(C)Cc1c(C)c2ccccc2n1C,,ClCCl,,CCN(CC)CC,,val
US20100216746A1,CC(C)C(=O)NC(C#N)COCc1ccccc1.ClC(Cl)(Cl)Cl>>CC(C)c1nc(Cl)c(COCc2ccccc2)[nH]1,,CC#N,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050245503A1,CCOC(=O)CN(C)S(=O)(=O)c1cnc(NN)c(Cl)c1.O=C=NC1c2ccccc2CCc2ccccc21>>CCOC(=O)CN(C)S(=O)(=O)c1cnc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c(Cl)c1,,CC(=O)N(C)C,,c1ccncc1,,val
US20080171737A1,C=CCBr.O=S1(=O)COc2cc(F)ccc2N1c1ccccc1>>C=CCC1Oc2cc(F)ccc2N(c2ccccc2)S1(=O)=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20090042892A1,COc1nccnc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C>>C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nccnc1O,,ClCCl,,BrB(Br)Br,,val
US06608085B1,C=O.OC(CNCc1ccccc1)c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12>>FC(F)(F)c1cc(C2CN(Cc3ccccc3)CO2)c2cccc(C(F)(F)F)c2n1,,CO,,,,val
US20080293706A1,CN(C)S(=O)(=O)Cl.Nc1cncc(Br)c1>>CN(C)S(=O)(=O)Nc1cncc(Br)c1,,ClCCl,,c1ccncc1,,val
US06458784B1,COC(=O)CC1Nc2ccc(C(=O)Nc3ccc(N)nc3)cc2CN(CCc2ccccc2)C1=O>>Nc1ccc(NC(=O)c2ccc3c(c2)CN(CCc2ccccc2)C(=O)C(CC(=O)O)N3)cn1,,C1CCOC1,O,[Li+].[OH-],,val
US20060230548A1,CC(C)CCON=O.N#CC(C#N)=C1CC(=O)c2ccccc21>>N#CC(C#N)=C1/C(=N\O)C(=O)c2ccccc21,,C1CCOC1,,Cl,,val
US05210092,CCCCc1nc2cccnc2n1Cc1ccc(-c2cc(Cl)sc2-c2nnn[nH]2)cc1>>CCCCc1nc2cccnc2n1Cc1ccc(-c2ccsc2-c2nnn[nH]2)cc1,[Pd],CO,,[K+].[OH-],,val
US20140114075A1,COC(OC)N(C)C.COc1cc(C(C)=O)c([N+](=O)[O-])cc1OCC1(NC(=O)OCc2ccccc2)CC1>>COc1cc(C(=O)C=CN(C)C)c([N+](=O)[O-])cc1OCC1(NC(=O)OCc2ccccc2)CC1,,CN(C)C=O,O,,,val
US04026936,N.O=C(c1ccc(Cl)c([N+](=O)[O-])c1)c1nccs1>>Nc1ccc(C(=O)c2nccs2)cc1[N+](=O)[O-],,CCO,,,,val
US20070099990A1,C[Mg]Br.Cc1c(C=O)c2c(c(C)c1NC(=O)CC(C)(C)C)C(c1ccc(C(C)C)cc1)CO2>>Cc1c(NC(=O)CC(C)(C)C)c(C)c2c(c1C(C)O)OCC2c1ccc(C(C)C)cc1,,O,,,,val
US20100105755A1,CCS(=O)(=O)c1cc(C(=O)O)c(OC)cc1N>>CCS(=O)(=O)c1cc(C(=O)O)c(O)cc1N,,ClCCl,,BrB(Br)Br,,val
US20110144105A1,CS(=O)(=O)c1ccc(C(=CC2CCOCC2)c2cc3cccnc3[nH]2)cc1>>CS(=O)(=O)c1ccc(C(CC2CCOCC2)c2cc3cccnc3[nH]2)cc1,[Pd],CO,,,,val
US20150315188A1,Cc1ccc2c(c1)c1c(n2CC(OC/C=C/C(=O)O)c2ccncc2)CCN(C)C1>>Cc1ccc2c(c1)c1c(n2CC(OCCCC(=O)O)c2ccncc2)CCN(C)C1,[Pd],O,,,,val
US20040235852A1,CCc1cc(C=O)cc2c(C)coc12.CO.N#Cc1ccc(N)cc1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>CCc1cc(C(Nc2ccc(C#N)cc2)C(=O)OC)cc2c(C)coc12,,CO,O,CCOCC,FB(F)F,val
US20160083367A1,Cc1nc(F)ccc1C#N.NC1(c2cc3cc(Cl)ccc3[nH]c2=O)CC1>>Cc1nc(NC2(c3cc4cc(Cl)ccc4[nH]c3=O)CC2)ccc1C#N,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2C(C)(C)C.ClCCCN1CCOCC1>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCCN3CCOCC3)cc1CC2C(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030092677A1,CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccccc2)cc1N.ClCCl.Cn1ccnc1-c1cccc(C(=O)CC(=O)OC(C)(C)C)c1>>Cc1cc2c(cc1C#Cc1ccccc1)NC(=O)CC(c1cccc(-c3nccn3C)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140315894A1,COc1ccc(C2=NN(c3ccccc3)C(=O)C2)cc1.N#CCC#N.O=Cc1ccccc1>>COc1ccc(-c2nn(-c3ccccc3)c3c2C(c2ccccc2)C(C#N)=C(N)O3)cc1,,CCO,,CCN(CC)CC,,val
US20110224257A1,C#CCBr.O=C(Cn1nc(C(F)F)cc1C(F)F)N1CCC(c2nc(C3=NOC(c4c(O)cccc4Cl)C3)cs2)CC1>>C#CCOc1cccc(Cl)c1C1CC(c2csc(C3CCN(C(=O)Cn4nc(C(F)F)cc4C(F)F)CC3)n2)=NO1,,CN(C)C=O,,Cl,[I-].[K+],val
US20160024082A1,CC(C)(C)OC(=O)N1CCc2c(Cl)ncnc2C1.CC1(C)OB(c2cn[nH]c2)OC1(C)C>>CC(C)(C)OC(=O)N1CCc2c(ncnc2-c2cn[nH]c2)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20090239845A1,Cc1cc(N)nn1Cc1cc(Cl)ccc1OCC(C)C.O=C(OCc1ccccc1C(=O)Cl)c1ccccc1>>Cc1cc(NC(=O)c2ccccc2COC(=O)c2ccccc2)nn1Cc1cc(Cl)ccc1OCC(C)C,,ClCCl,,c1ccncc1,,val
US20040204450A1,CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(=NN)C[C@H]1CC.II>>CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(I)=C[C@H]1CC,,C1CCOC1,,CN(C)C(=N)N(C)C,,val
US20150105317A1,[N-]=[N+]=NCCO[C@H]1O[C@H](C(O)C(c2ccccc2)(c2ccccc2)c2ccccc2)[C@@H](OC(=O)c2ccccc2)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1>>[N-]=[N+]=NCCO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccccc2)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05047411,COc1ccn2c(C)c(CCc3ccc4nc(N)oc4c3)nc2c1.O>>COc1ccn2c(C)c(CCc3ccc4nc(O)oc4c3)nc2c1,,Cl,,,,val
US20100041696A1,BrCC1CCCCC1.CC(C)(C)OC(=O)N1CCc2cc(C(=O)Nc3cn[nH]c3)ccc2C1>>CC(C)(C)OC(=O)N1CCc2cc(C(=O)Nc3cnn(CC4CCCCC4)c3)ccc2C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040198982A1,BrBr.COC(=O)[C@H](CC(C)C)Nc1ccsn1>>COC(=O)[C@H](CC(C)C)Nc1nscc1Br,,CC(=O)O,ClCCl,,,val
US06265575B1,COc1ccc(-c2sc3ccccc3c2C(=O)c2ccc(OCCN3CCCC3)cc2)cc1>>O=C(c1ccc(OCCN2CCCC2)cc1)c1c(-c2ccc(O)cc2)sc2ccccc12,,ClCCl,,CO,,val
US04317817,C[C@@H](CO)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C(=[N+]=[N-])C(=O)CC[C@]4(C)[C@H]3CC[C@]12C>>C[C@@H](C=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C(=[N+]=[N-])C(=O)CC[C@]4(C)[C@H]3CC[C@]12C,,CCOCC,ClCCl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20090137609A1,CCC(CC)(c1ccc(C#CC(OCOC)(C(F)(F)F)C(F)(F)F)c(C)c1)c1ccc(-c2ccc(CC(=O)OC)c(F)c2)c(C)c1>>CCC(CC)(c1ccc(C#CC(O)(C(F)(F)F)C(F)(F)F)c(C)c1)c1ccc(-c2ccc(CC(=O)OC)c(F)c2)c(C)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110217311A1,CO[C@@H]1CCC[C@H](Oc2ncccc2Nc2ncnc3sc(C(=O)O)c(C)c23)C1.N>>CO[C@@H]1CCC[C@H](Oc2ncccc2Nc2ncnc3sc(C(N)=O)c(C)c23)C1,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US04868061,CC=CCN(CC(=O)OCC)C(=O)Nc1ccc(C(CCC)=NO)cc1>>CC=CCN1CC(=O)N(c2ccc(C(CCC)=NO)cc2)C1=O,,CO,,CO[Na],,val
US04670604,COC(=O)C(=O)Cl.COc1cccc(N)c1>>COC(=O)C(=O)Nc1cccc(OC)c1,,ClCCl,,c1ccncc1,,val
US20050009817A1,COC(=O)CCC(=O)c1c[nH]c2ccc(Br)cc12.COc1ccc(Nc2nc(Cl)nc3ccc(-c4ccco4)cc23)cc1>>COC(=O)CCC(=O)c1cn(-c2nc(Nc3ccc(OC)cc3)c3cc(-c4ccco4)ccc3n2)c2ccc(Br)cc12,CN(C)c1ccncc1,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120232056A1,COC(=O)c1ccc2nc(-c3cnn(C)c3)c(N(C)C(C)C)nc2c1>>CC(C)N(C)c1nc2cc(C(=O)O)ccc2nc1-c1cnn(C)c1,,CO,ClC(Cl)Cl,O,[Na+].[OH-],val
US05677459,CN1CCCC1c1cncc([Si](C)(C)C)c1.O=C(O)/C=C/C(=O)O>>CN1CCCC1c1cncc([Si](C)(C)C)c1.O=C(O)/C=C/C(=O)O,,CO,,,,val
US20150031708A1,COc1ccc(C2(C(=O)Nc3ccc(C)c(-c4cccnc4OC)n3)CC2)cc1>>COc1ccc(C2(C(=O)Nc3ccc(C)c(-c4ccc[nH]c4=O)n3)CC2)cc1,,C1COCCO1,,Cl,,val
US20110245220A1,CC(C)(C)OC(=O)N1CCC(O)(c2cc(F)c(O[Si](C)(C)C(C)(C)C)c(F)c2)CC1>>CC(C)(C)OC(=O)N1CCC(O)(c2cc(F)c(O)c(F)c2)CC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150175557A1,CC(C)(C)OC(=O)NC1CCCC(O)C1>>CC(C)(C)OC(=O)NC1CCCC(=O)C1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090029963A1,CC(=O)Cl.CCOC(=O)c1c(CN)nn(-c2cccc(OC(F)(F)F)c2)c1C1CC1>>CCOC(=O)c1c(CNC(C)=O)nn(-c2cccc(OC(F)(F)F)c2)c1C1CC1,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20050004162A1,CCOC(=O)Cc1csc2ccc(Cl)cc12>>OCCc1csc2ccc(Cl)cc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05939411,BrCCOC1CCCCO1.N#CCc1ccc(F)c(F)c1>>NCC(CCOC1CCCCO1)c1ccc(F)c(F)c1,,C1CCOC1,,[H-].[Na+],,val
US20080287409A1,COc1cc(OCc2sc(-c3ccc(C(F)(F)F)cc3)nc2CN2CCC(C(F)(F)F)CC2)ccc1C(=N)NO.O=C(Cl)Oc1ccccc1>>COc1cc(OCc2sc(-c3ccc(C(F)(F)F)cc3)nc2CN2CCC(C(F)(F)F)CC2)ccc1-c1noc(=O)[nH]1,,ClCCl,,O,c1ccncc1,val
US06413995B1,CC(C)(C)OC(=O)CBr.Sc1ccc(Br)cc1>>CC(C)(C)OC(=O)CSc1ccc(Br)cc1,,CCO,,[K+].[OH-],,val
US05180741,N#C[Cu]C#N.O=C1CCc2ccc(Br)cc21>>N#Cc1ccc2c(c1)C(=O)CC2,,ClCCl,,CN(C)C=O,O,val
US05614521,O=C(C=Cc1ccc(OCc2ccccc2)c([N+](=O)[O-])c1)N1CCCCC1>>Nc1cc(CCC(=O)N2CCCCC2)ccc1O,[Pd],CO,,,,val
US06562825B1,CN(C)C(=O)COc1cc(Cl)ccc1C(=O)NCCN1CCN(C(=O)OC(C)(C)C)CC1.O=C(O)C(F)(F)F>>CN(C)C(=O)COc1cc(Cl)ccc1C(=O)NCCN1CCNCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20160016961A1,CC(C)(C)NS(=O)(=O)c1cncc(B2OC(C)(C)C(C)(C)O2)c1.Clc1cc(NCc2ccccc2)c2c(Cl)ccn2n1>>CC(C)(C)NS(=O)(=O)c1cncc(-c2cc(NCc3ccccc3)c3c(Cl)ccn3n2)c1,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100048666A1,CC(C)[N+](=O)[O-].COC(=O)C(C)c1cc(Br)c(CBr)cc1OC>>COC(=O)C(C)c1cc(Br)c(C=O)cc1OC,,CO,,C[O-].[Na+],,val
US20020052378A1,CCOC(=O)C(CC1CCCCC1)C(=O)OCC>>CCOC(=O)C(CC1CCCCC1)C(=O)O,,CCO,O,[Li+].[OH-],,val
US20120329848A1,CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C(F)(F)F.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C(F)(F)F.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,,CC(C)=O,,,,val
US20030013687A1,C=C(C)C(=O)OCc1ccccc1.CC(C)(C)OC(=O)CCC(C[PH](=O)OC(C)(C)C)C(=O)OC(C)(C)C>>CC(CP(=O)(CC(CCC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)OC(C)(C)C)C(=O)OCc1ccccc1,,C1CCOC1,CCOCC,O,[H-].[Na+],val
US20140079636A1,CCc1c2c(nc3ccc(OC(=O)OC(C)(C)C)cc13)-c1cc3c(c(=O)n1C2)COC(=O)C3(CC)OC(=O)N(C)CCCCN1CCN(Cc2ccc(-n3c(O)nnc3-c3cc(C(C)C)c(O)cc3O)cc2)CC1>>CCc1c2c(nc3ccc(O)cc13)-c1cc3c(c(=O)n1C2)COC(=O)C3(CC)OC(=O)N(C)CCCCN1CCN(Cc2ccc(-n3c(O)nnc3-c3cc(C(C)C)c(O)cc3O)cc2)CC1,,C1COCCO1,ClCCl,Cl,,val
US04997847,O=C(O)CCC/C=C\CN1C(=O)c2ccccc2C1=O>>NC/C=C\CCCC(=O)O,,CCO,O,NN,,val
US20090105307A1,COc1cc(N(Cc2ccccc2)C[C@H]2COC(N)=N2)ccc1F>>COc1cc(NC[C@H]2COC(N)=N2)ccc1F,[Pd],CO,,O=C[O-].[NH4+],,val
US20160002205A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.CN1CCNCC1>>CN1CCN(C2CCN(C(=O)OC(C)(C)C)CC2)CC1,,CCO,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100240661A1,CC12CN(CCCn3nc(-c4cccnc4F)c(=O)[nH]c3=O)CC1(c1ccc(C(F)(F)F)cc1)C2.Cl.ClCCl>>CC12CN(CCCn3nc(-c4cccnc4F)c(=O)[nH]c3=O)CC1(c1ccc(C(F)(F)F)cc1)C2.Cl.Cl,,ClCCl,,CO,,val
US20100310457A1,COc1cc(/C=C/c2ccc(C#N)cc2)ccc1C(OC)OC>>COc1cc(/C=C/c2ccc(C#N)cc2)ccc1C=O,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05616599,CCCCc1nc(C(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCCCc1nc(C(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,CC(=O)O,,,,val
US20100035926A1,NCCF.Nc1c(C(=O)NCC2(C(F)(F)F)CO2)cnn1-c1ccc(F)cc1>>Nc1c(C(=O)NCC(O)(CNCCF)C(F)(F)F)cnn1-c1ccc(F)cc1,,CC#N,,CCN(CC)CC,Cl,val
US03954440,CS(=O)(=O)Cl.OCC(O)(CC(Cl)(Cl)Cl)c1ccccc1>>CS(=O)(=O)OCC(O)(CC(Cl)(Cl)Cl)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20110183985A1,Brc1ncnc2[nH]cnc12.CC(N)c1cc(Cl)c2ccncc2c1-c1cccc(F)c1>>CC(Nc1ncnc2[nH]cnc12)c1cc(Cl)c2ccncc2c1-c1cccc(F)c1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US04192796,CC(C)(C)C1=CC(=O)C=C(C(C)(C)C)C1=O.N#CCC[PH](=O)CCC#N>>CC(C)(C)c1cc(OP(=O)(CCC#N)CCC#N)cc(C(C)(C)C)c1O,,O,,CC(=O)N(C)C,,val
US20160143870A1,CC(C)C(=O)Cl.CCC(N)CC>>CCC(CC)NC(=O)C(C)C,,ClCCl,,CCN(CC)CC,,val
US20090036466A1,Cc1cc(C)c2nc(NCCCN3CCCCC3)n(Cc3nc(C)ccc3OCc3ccccc3)c2c1>>Cc1cc(C)c2nc(NCCCN3CCCCC3)n(Cc3nc(C)ccc3O)c2c1,[Pd],CO,,,,val
US20120101099A1,C#Cc1ccc(COS(C)(=O)=O)cc1.C1COCCN1>>C#Cc1ccc(CN2CCOCC2)cc1,,ClCCl,,CCN(CC)CC,,val
US20120232122A1,CN(C)C=O.C[C@]12CCc3c(Br)cccc3[C@H]1CN(Cc1ccccc1)C2>>C[C@]12CCc3c(C=O)cccc3[C@H]1CN(Cc1ccccc1)C2,,C1CCOC1,,[Li]CCCC,,val
US20140221332A1,COC1=NCCCC1.NNC(=O)c1ccc(Br)cc1>>Brc1ccc(-c2nnc3n2CCCC3)cc1,,CN(C)C=O,O,,,val
US20140094462A1,C=CCCC(=O)O.N[C@@H]1c2ccccc2C[C@H]1O>>C=CCCC(=O)N[C@@H]1c2ccccc2C[C@H]1O,,CN(C)C=O,,CCCCCC,CCOC(C)=O,val
US05686424,C/C(=C\c1ccccc1)CO.CC[C@H](C)[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)O>>CC[C@H](C)[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)OCC=C(C)c1ccccc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20160194350A1,CC[C@H](OC(=O)C(C)C)[C@@H]1C[C@@H](OC(C)=O)[C@H](n2c(=O)sc3c(=O)[nH]c(N)nc32)O1>>CC[C@H](OC(=O)C(C)C)[C@@H]1C[C@@H](O)[C@H](n2c(=O)sc3c(=O)[nH]c(N)nc32)O1,,C1CCOC1,CO,O=C([O-])[O-].[K+].[K+],,val
US20160031904A1,CCOC(=O)c1cccnc1F.F[C@H]1CCNC1>>CCOC(=O)c1cccnc1N1CC[C@H](F)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20060041146A1,CC(C)(C)OC(=O)NC(N)=S.CCSC(=O)CBr>>CCSc1csc(NC(=O)OC(C)(C)C)n1,,CCO,,,,val
US20120178751A1,Cc1ncc(B2OC(C)(C)C(C)(C)O2)cc1[N+](=O)[O-].Fc1ccccc1-c1ccc2nc(Cl)cn2n1>>Cc1ncc(-c2cn3nc(-c4ccccc4F)ccc3n2)cc1[N+](=O)[O-],,CC(C)O,O,O=C([O-])[O-].[Na+].[Na+],,val
US04055595,CCN(CC)CCO.O=C(Cl)C(OCc1ccc(-c2ccc(Cl)cc2)cc1)(C(F)(F)F)C(F)(F)F>>CCN(CC)CCOC(=O)C(OCc1ccc(-c2ccc(Cl)cc2)cc1)(C(F)(F)F)C(F)(F)F.Cl,,c1ccncc1,,,,val
US04486438,CC(Cl)C(=O)Cl.Nc1ccccc1C(=O)O>>CC(Cl)c1nc2ccccc2c(=O)o1,,Cc1ccccc1,,,,val
US20160137696A1,CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)OC(C)(C)C.[N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN>>CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCC(=O)N[C@@H](CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140274701A1,ClCBr.Oc1cc(F)c(Br)cc1O>>Fc1cc2c(cc1Br)OCO2,,CCOCC,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20100094000A1,CN(C)C(=O)Cl.Cc1nn(CC(F)(F)CO)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2>>Cc1nn(CC(F)(F)COC(=O)N(C)C)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2,,c1ccncc1,,,,val
US20110312941A1,O=C(C1CCN(c2ccccc2[N+](=O)[O-])CC1)N1Cc2cccn2Cc2ccccc21>>Nc1ccccc1N1CCC(C(=O)N2Cc3cccn3Cc3ccccc32)CC1,[Pd],CCO,,CN(C)C=O,,val
US20040116465A1,CCOc1ccc(Cc2nc3cc(S(=O)(=O)Cl)ccc3n2CC2CC2)cc1.CN1CCNCC1>>CCOc1ccc(Cc2nc3cc(S(=O)(=O)N4CCN(C)CC4)ccc3n2CC2CC2)cc1.Cl,,CCOCC,ClCCl,,,val
US20090197871A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2cc(Br)cc(OC)c2)c1.C[C@H]1CN(Cc2cccc(B(O)O)c2)CCN1C(=O)OC(C)(C)C>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2cc(OC)cc(-c3cccc(CN4CCN(C(=O)OC(C)(C)C)[C@@H](C)C4)c3)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20140058100A1,C[C@@H](O)C(=O)OC(C)(C)C.O=C(NCCc1cccc(O)c1)C1c2ccccc2C(=O)N(C2CCCCC2O)C1c1ccc(Cl)cc1Cl>>C[C@H](Oc1cccc(CCNC(=O)C2c3ccccc3C(=O)N(C3CCCCC3O)C2c2ccc(Cl)cc2Cl)c1)C(=O)OC(C)(C)C,,C1CCOC1,CCOC(C)=O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccccc4F)nc(Cl)c3n2)cc1.COc1ccc(N)cc1OC>>COc1ccc(Nc2nc(-c3ccccc3F)nc3cn[nH]c23)cc1OC,C1COCCO1,CO,,Cl,,val
US04562179,CCCCCCCCCCCCCCCCC(O)COC(c1ccccc1)(c1ccccc1)c1ccccc1.CI>>CCCCCCCCCCCCCCCCC(COC(c1ccccc1)(c1ccccc1)c1ccccc1)OC,,C1CCOC1,,[H-].[Na+],,val
US20150031679A1,COC(=O)c1ccc2c(c1)nc(Cl)c(=O)n2Cc1ccccc1.C[C@H]1CCCN1>>COC(=O)c1ccc2c(c1)nc(N1CCC[C@@H]1C)c(=O)n2Cc1ccccc1,,CS(C)=O,,,,val
US20100022598A1,CC(C)(C)C(=O)CBr.CC(O)(CC(=N)N)c1ccc(-c2ccc(F)cn2)cc1F>>CC(C)(C)c1c[nH]c(CC(C)(O)c2ccc(-c3ccc(F)cn3)cc2F)n1,,C1CCOC1,O,O=C([O-])O.[K+],,val
US20070203137A1,N#Cc1ccc2[nH]c(O)c(-c3ccc(CN4CCOCC4)cn3)c2c1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>N#Cc1ccc2[nH]c(O)c(-c3ccc(CN4CCOCC4)cn3)c2c1.O=C(O)CC(O)(CC(=O)O)C(=O)O,,CCO,O,C,,val
US20070287699A1,O=C(OCc1ccccc1)N1CCc2c(c(=O)c(-c3noc(Cc4ccccc4)n3)cn2Cc2ccc(C(F)(F)F)cc2F)C1>>O=c1c(-c2noc(Cc3ccccc3)n2)cn(Cc2ccc(C(F)(F)F)cc2F)c2c1CNCC2,,Br,CC(=O)O,,,val
US20130237525A1,CCCC[Sn](CCCC)(CCCC)c1nccs1.COC(=O)c1cccc(Br)n1>>COC(=O)c1cccc(-c2nccs2)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,CCOC(C)=O,O,val
US20040058903A1,O=C(Nc1ccc(C#Cc2ncccn2)cc1)c1ccccc1-c1ccc(C(F)(F)F)cc1>>O=C(Nc1ccc(CCc2ncccn2)cc1)c1ccccc1-c1ccc(C(F)(F)F)cc1,[Pd],CO,,[H][H],,val
US20120029002A1,CC(C)OC(=O)Cl.Nc1nc(-n2nc(Oc3ccccc3F)c3ccccc32)nc(N)c1N>>CC(C)OC(=O)Nc1c(N)nc(-n2nc(Oc3ccccc3F)c3ccccc32)nc1N,,ClCCl,,c1ccncc1,,val
US20070259896A1,CC(=O)OC(C)=O.Nc1ccc(CCCNc2ncnc3scc(-c4ccc(F)cc4)c23)cc1>>CC(=O)Nc1ccc(CCCNc2ncnc3scc(-c4ccc(F)cc4)c23)cc1,,ClCCl,,,,val
US20130252937A1,COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(O)cc5C)ccc(F)c43)ccc21.Cn1ccc(CCl)cc1=O>>COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(OCc6ccn(C)c(=O)c6)cc5C)ccc(F)c43)ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080318968A1,Cc1cnc(NC(=O)c2cc(OCc3ccccc3)cc(O[C@@H](C)COC(F)F)c2)cn1>>Cc1cnc(NC(=O)c2cc(O)cc(O[C@@H](C)COC(F)F)c2)cn1,,CCO,,,,val
US20080045556A1,COC(=O)C(=O)C(F)(F)F.Nc1nc(-c2ccc(Br)cc2)cs1>>COC(=O)[C@@H](Nc1nc(-c2ccc(Br)cc2)cs1)C(F)(F)F,Cl[Ti](Cl)(Cl)Cl,CO,ClCCl,[BH3-]C#N.[Na+],,val
US05968937,C1=CNc2ccccc2C=N1.C1CCOC1.Cc1ccccc1C(=O)N(C)c1ccc(C(=O)Cl)cc1>>Cc1ccccc1C(=O)N(C)c1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1,,ClCCl,O,CCN(CC)CC,,val
US20100144707A1,COc1ccc2nc(-c3cccc([N+](=O)[O-])c3)[nH]c(=O)c2c1>>O=c1[nH]c(-c2cccc([N+](=O)[O-])c2)nc2ccc(O)cc12,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20050026976A1,O=C1NCc2c(Br)cccc21.O=[N+]([O-])O>>O=C1NCc2c(Br)ccc([N+](=O)[O-])c21,,O=S(=O)(O)O,,,,val
US20020007059A1,Cn1oc(=O)cc1N.N#Cc1cccc(C=O)c1.O=C1COCC(=O)C1>>Cn1oc(=O)c2c1NC1=C(C(=O)COC1)C2c1cccc(C#N)c1,,CCO,,,,val
US20040235891A1,CC(C(=O)O)c1ccc(F)cc1.COc1ccc(CCN)cc1>>COc1ccc(CCNC(=O)C(C)c2ccc(F)cc2)cc1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20140323464A1,COc1ccc(N)cc1Nc1ncc(F)c(Nc2ccccc2)n1.N#CCC(=O)O>>COc1ccc(NC(=O)CC#N)cc1Nc1ncc(F)c(Nc2ccccc2)n1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150368246A1,CC=O.Nc1ccc(Cl)nc1-c1cc2c(F)cccc2[nH]1>>CC1Nc2ccc(Cl)nc2-c2cc3c(F)cccc3n21,,CC(=O)O,,CCOC(C)=O,O=C([O-])O.[Na+],val
US20100158863A1,C1CCNC1.Fc1cc(Br)ccc1OCCCCl>>Fc1cc(Br)ccc1OCCCN1CCCC1,,CC(=O)N(C)C,,,,val
US20050197331A1,Nc1ccc([N+](=O)[O-])cc1N.O=C(O)c1ccccc1F>>O=[N+]([O-])c1ccc2nc(-c3ccccc3F)[nH]c2c1,,CCOC(C)=O,Cc1ccccc1,[Br-].[K+],,val
US20120010189A1,CCOC(=O)c1nnc(-c2ccccc2)o1.COc1cc(OC2CNC2)ccc1CN1CCOCC1>>COc1cc(OC2CN(C(=O)c3nnc(-c4ccccc4)o3)C2)ccc1CN1CCOCC1,,CCO,,,,val
US20080108613A1,CN.Fc1cccc(COc2ccc(Nc3ncnc4[nH]nc(OCCCl)c34)cc2Cl)c1>>CNCCOc1n[nH]c2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12,,CCO,O,,,val
US20090234132A1,FCCBr.O=C1NCCc2cncn21>>O=C1NCCc2c[n+](CCF)cn21.[Br-],,CC#N,,,,val
US20040220404A1,COc1cc([N+](=O)[O-])ccc1OCCN1CCC(F)(F)C1>>COc1cc(N)ccc1OCCN1CCC(F)(F)C1,[Pd],CCOC(C)=O,,,,val
US20060004046A1,COc1ccc(/C=C2\SC(=N)NC2=O)cc1OC1CCCC1.N#Cc1cnc2ccc(C=O)cc2c1OC1CCOCC1>>N#Cc1cnc2ccc(/C=C3\SC(N)=NC3=O)cc2c1OC1CCOCC1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US05840911,COc1ccccc1C(=O)CBr.N=C(N)NN=Cc1ccccc1>>COc1ccccc1-c1cn(N=Cc2ccccc2)c(N)n1,,CCO,,,,val
US04113715,COc1ccc(COC(=O)NCCCC(CSC(C)=O)C(=O)N2CCC[C@H]2C(=O)OC(C)(C)C)cc1.O=C(O)C(F)(F)F>>CC(=O)SCC(CCCN)C(=O)N1CCC[C@H]1C(=O)O.O=C(O)C(F)(F)F,,COc1ccccc1,,,,val
US20100105657A1,CN1CCCc2ccc(N)cc2C1.O=S(=O)(Cl)c1cccc(Cl)c1Cl>>CN1CCCc2ccc(NS(=O)(=O)c3cccc(Cl)c3Cl)cc2C1,,ClCCl,,c1ccncc1,,val
US20160031829A1,CSc1cc(C#N)ccc1C(NC(=O)OC(C)(C)C)C1=C(Nc2cccc(C(F)(F)F)c2)CCC1=O.Cl>>CSc1cc(C#N)ccc1C(N)C1=C(Nc2cccc(C(F)(F)F)c2)CCC1=O.Cl,,CC#N,,C1COCCO1,,val
US20120065195A1,CN1C(=O)NC2(C1=O)c1cc(-c3cccc(Cl)c3)ncc1CCC2(C)C.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CN1C(=O)C2(NC1=S)c1cc(-c3cccc(Cl)c3)ncc1CCC2(C)C,,Cc1ccccc1,,,,val
US20160106711A1,COC(=O)c1cccc2c1NC(=O)C2=O.COc1ccc([Mg]Br)cc1>>COC(=O)c1cccc2c1NC(=O)C2(O)c1ccc(OC)cc1,,C1CCOC1,,,,val
US20030236230A1,COC(=C=O)CC1(C2CCCCC2)CCN(C(=O)OC(C)(C)C)CC1>>CC(C)(C)OC(=O)N1CCC(CCC=O)(C2CCCCC2)CC1,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US20040138230A1,CC1C(=O)Nc2ccc(C(=O)CCl)cc2C1C>>CC1C(=O)Nc2ccc(CCCl)cc2C1C,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US04489093,C#CCN1CC(=O)N(CO)C1=O.CCOC(=O)/C(F)=C\[C@H]1[C@@H](C(=O)O)C1(C)C>>C#CCN1CC(=O)N(COC(=O)[C@@H]2[C@H](/C=C(/F)C(=O)OCC)C2(C)C)C1=O,,ClC(Cl)Cl,,,,val
US20070155813A1,COC(=O)C=C1CCP(c2ccccc2)C1(c1ccccc1)c1ccccc1.COCOc1cc(OCOC)c(-c2ccc(C=O)o2)c(CC(=O)OC)c1Br>>COCOc1cc(OCOC)c(-c2ccc(C=CC(=O)OC)o2)c(CC(=O)OC)c1Br,,Cc1ccccc1,,,,val
US06403601B1,O=C(O)c1cc2ccccc2cc1O>>O=C(O)c1cc2c(cc1O)CCCC2,[Pd],CC(=O)O,,,,val
US20110257198A1,C=C[Sn](CCCC)(CCCC)CCCC.COC(=O)c1ccc(C)nc1Cl>>C=Cc1nc(C)ccc1C(=O)OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US06627651B1,C=O.Cc1ccc(-c2ccc3c(c2)C=C(C(=O)NC2CCNCC2)CCO3)cc1>>Cc1ccc(-c2ccc3c(c2)C=C(C(=O)NC2CCN(C)CC2)CCO3)cc1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20150025070A1,COCCNCc1nc2c(c(=O)[nH]1)COCC2.COc1ccc(C(=O)C2CCN(CC(=O)O)CC2)cc1>>COCCN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(OC)cc2)CC1,,CC#N,,,,val
US04920133,CC(=O)c1ccc(O)cc1.O=Cc1cccc(OCc2ccc3ccccc3n2)c1>>O=C(C=Cc1cccc(OCc2ccc3ccccc3n2)c1)c1ccc(O)cc1,,CCO,,C,C[O-].[Na+],val
US20030195199A1,CCCCCC(C)OC(=O)c1sc(N)c(C(=O)OC(C)(C)C)c1C.CCCCCCCOC(=O)Cl>>CCCCCCCOC(=O)Nc1sc(C(=O)OC(C)CCCCC)c(C)c1C(=O)OC(C)(C)C,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US06936602B1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3c2ccc(S(=O)(=O)N(C)C)cc2)cc1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCN3c2ccc(S(=O)(=O)N(C)C)cc2)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20110112067A1,CCBr.O=C1CCc2cc(Br)ccc2N1>>CCN1C(=O)CCc2cc(Br)ccc21,,CN(C)C=O,Cl,CC(C)(C)[O-].[K+],,val
US20120270824A1,CC(=O)OC[C@H]1O[C@H](Oc2ccc(-n3ccc4cc(C#N)cnc43)cc2Cl)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>N#Cc1cnc2c(ccn2-c2ccc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)c(Cl)c2)c1,,CO,,,,val
US20130059832A1,CC(C)[Si](Cl)(C(C)C)C(C)C.CCOC(=O)c1cnc2ccc(CO)cn12>>CCOC(=O)c1cnc2ccc(CO[Si](C(C)C)(C(C)C)C(C)C)cn12,CN(C)c1ccncc1,ClCCl,,c1c[nH]cn1,,val
US20150210682A1,CC(=O)Cl.CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCN)cc1CC2CC>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCNC(C)=O)cc1CC2CC,,CC#N,,CCN(CC)CC,,val
US20150266862A1,CC(C)CI.O=Cc1cccc(O)c1>>CC(C)COc1cccc(C=O)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040122038A1,CCN(CC)CC.CCOC(C)=O.CCn1c(=O)c2ccc(N)cc2c2ccccc21.On1nnc2ccccc21>>CCn1c(=O)c2ccc(NC(=O)Cc3ccncc3)cc2c2ccccc21,,CCOC(C)=O,ClCCl,CCN=C=NCCCN(C)C,Cl,val
US20070149525A1,CC(C)C1CC1(NCC(O)C(Cc1cc(F)cc(F)c1)NC(=O)OC(C)(C)C)c1cccc(-n2cccn2)c1>>CC(C)C1CC1(NCC(O)C(N)Cc1cc(F)cc(F)c1)c1cccc(-n2cccn2)c1,,C1COCCO1,Cl,,,val
US20130158003A1,Nc1ccccc1S.O=C(O)CCc1cnc2ccccc2n1>>c1ccc2nc(CCc3nc4ccccc4s3)cnc2c1,,[Na+],[OH-],,,val
US20070287695A1,C=CCN1C(=O)N(C2CCN(C(=O)OC(C)(C)C)CC2)[C@H]2CCCC[C@@H]21>>C=CCN1C(=O)N(C2CCNCC2)[C@H]2CCCC[C@@H]21,,CO,,Cl,,val
US20080009518A1,C[C@@H](O[C@H]1CCc2c(ccc(CNC(=O)OC(C)(C)C)[n+]2[O-])[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl>>C[C@@H](O[C@H]1CCc2c(ccc(CN)[n+]2[O-])[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl,,C1COCCO1,,,,val
US04753950,Nc1c2c(nc3cnccc13)CCCC2=O>>Nc1c2c(nc3cnccc13)CCCC2O,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080300232A1,O=C(CCl)NC1CCN(Cc2ccccc2)CC1.Oc1cccc(Cl)c1>>O=C(COc1cccc(Cl)c1)NC1CCN(Cc2ccccc2)CC1,,C1CCOC1,,O,CC(C)(C)[O-].[K+],val
US20110275611A1,CNc1nc(-c2cc(F)c(C#N)c(OC)c2)cc(N2CCC[C@H]2C(F)(F)F)n1.NN>>CNc1nc(-c2cc(OC)c3c(N)n[nH]c3c2)cc(N2CCC[C@H]2C(F)(F)F)n1,,CCO,,O,,val
US20160159820A1,COC(=O)c1ccc(CN2CC(C)N(C(=O)OC(C)(C)C)C(C)C2)c(C(F)(F)F)c1>>CC1CN(Cc2ccc(C(=O)O)cc2C(F)(F)F)CC(C)N1C(=O)OC(C)(C)C,,CO,,[Na+].[OH-],,val
US20080262042A1,CN(Cc1cn(S(=O)(=O)c2nccs2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C.Cl>>CNCc1cn(S(=O)(=O)c2nccs2)c(-c2cccnc2F)c1F.Cl,,CCO,CCOC(C)=O,,,val
US20060025599A1,N#C[C@@H]1CC(=O)N(c2ccc(OCc3cccc(F)c3)cc2)C1.NO>>N=C(NO)[C@@H]1CC(=O)N(c2ccc(OCc3cccc(F)c3)cc2)C1,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20150065464A1,CCOC(=O)c1c(C)n[nH]c1C(C)C>>Cc1n[nH]c(C(C)C)c1C(=O)O,,CCO,O,[Na+].[OH-],,val
US04840883,Nc1cc(Cl)c([N+](=O)[O-])cc1O.O=C(Cl)c1ccccc1>>O=C(Nc1cc(Cl)c([N+](=O)[O-])cc1O)c1ccccc1,,CCOC(C)=O,,,,val
US20160046608A1,CC(=O)OC(C)=O.N#CC1(c2cc(Nc3cc(C(F)(F)F)ccn3)nc(N3CCC(F)(F)C3)n2)CCNCC1>>CC(=O)N1CCC(C#N)(c2cc(Nc3cc(C(F)(F)F)ccn3)nc(N3CCC(F)(F)C3)n2)CC1,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070270428A1,CS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)cc(Cl)n2)cc1.NC1CCCCC1>>CS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)cc(NC3CCCCC3)n2)cc1,,O,,Cl,,val
US04891363,CS(=O)(=O)Cl.OCCCCCCCOC1CCCCO1>>CS(=O)(=O)OCCCCCCCOC1CCCCO1,,c1ccccc1,,CCN(CC)CC,,val
US20120135964A1,COP(=O)(OC)OCCC[C@@H](COC(=O)Nc1cc2ccccc2cn1)N(C)C(=O)NCc1cccc(F)c1F>>CN(C(=O)NCc1cccc(F)c1F)[C@@H](CCCOP(=O)(O)O)COC(=O)Nc1cc2ccccc2cn1,,CC#N,,C[Si](C)(C)I,,val
US20140323468A1,CC1(C)OB(c2cncc(C(=O)N3CCCC3)c2)OC1(C)C.NC(=O)N1CCCc2cc(Br)cnc21>>NC(=O)N1CCCc2cc(-c3cncc(C(=O)N4CCCC4)c3)cnc21,,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20070066624A1,CC(C)(C)OC(=O)N1CCC(N2C(=O)OC[C@H]2c2ccsc2)CC1>>O=C1OC[C@@H](c2ccsc2)N1C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150344423A1,O=C(NCc1ccccc1)C(C(F)(F)F)C(F)(F)F>>FC(F)(F)C(CNCc1ccccc1)C(F)(F)F,,C1CCOC1,,,,val
US20130261101A1,C=Cc1c(C#N)c(Cl)cc(C(C)=O)c1OCCNC(=O)OC(C)(C)C>>C=Cc1c(C#N)c(Cl)cc(C(C)O)c1OCCNC(=O)OC(C)(C)C,,CO,,O,[BH4-].[Na+],val
US20090062280A1,COC(=O)C(=O)c1ccc(CCCOC(C)=O)cc1.COc1ccc(CNc2cc(OC)ccc2N)cc1>>COc1ccc(Cn2c(=O)c(-c3ccc(CCCOC(C)=O)cc3)nc3ccc(OC)cc32)cc1,,C1CCOC1,CC(=O)O,,,val
US20080139631A1,O=C(CCl)NNC(=O)c1cncc(Br)c1>>ClCc1nnc(-c2cncc(Br)c2)o1,,O=P(Cl)(Cl)Cl,,,,val
US05246933,CCO.CCOC(=O)CBr.Nc1ccc(F)cc1>>CCN(CC(=O)O)c1ccc(F)cc1,,CCO,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20130217662A1,N#Cc1cccc(N=C=O)c1.Nc1cnc2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nn12>>N#Cc1cccc(NC(=O)Nc2cnc3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nn23)c1,,ClCCl,,,,val
US20110009402A1,CC(=O)C[C@]1(c2ccccc2)CCN([C@@H](C)c2ccc(Br)cc2)C(=O)O1.C[Mg]Br>>CC(C)(O)CC1(c2ccccc2)CCNC(=O)O1,,C1CCOC1,,,,val
US20140228394A1,Cc1ccncc1N1CCNC1=O.FC(F)(F)c1ccc(Br)cc1>>Cc1ccncc1N1CCN(c2ccc(C(F)(F)F)cc2)C1=O,I[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20140031563A1,BrC/C(=C(\CBr)c1ccccc1)c1ccccc1.Nc1ccc(Cl)cc1>>Clc1ccc(N2CC(c3ccccc3)=C(c3ccccc3)C2)cc1,,ClCCl,,O,,val
US05744488,NNc1ccc([N+](=O)[O-])cc1.O=CCCc1cccnc1>>O=[N+]([O-])c1ccc(NN=CCCc2cccnc2)cc1,,CCOCC,,,,val
US20050203151A1,COC(=O)COc1ccc2c(c1)CCN2CCc1sc(-c2ccc(C(F)(F)F)cc2)nc1C>>Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CCN1CCc2cc(OCC(=O)O)ccc21,,C1CCOC1,CO,[Li+].[OH-],,val
US20120165332A1,COc1cc(N)cc(OC)c1OC.COc1ccc(Nc2nc(Cl)ncc2Cl)c(NS(C)(=O)=O)c1>>COc1ccc(Nc2nc(Nc3cc(OC)c(OC)c(OC)c3)ncc2Cl)c(NS(C)(=O)=O)c1,,CC(C)O,,C1COCCO1,Cl,val
US06258829B1,CCOC(=O)c1cc2c(nc1C)C(O[N+](=O)[O-])CCCC2>>Cc1nc2c(cc1C(=O)O)CCCCC2O[N+](=O)[O-],,CO,,[Na+].[OH-],,val
US04820834,CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)O.Nc1ccc(Cl)cc1C(=O)c1ccccc1>>O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1ccccc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100093703A1,COC(=O)c1ccc(=O)[nH]n1.O=S(Cl)Cl>>COC(=O)c1ccc(Cl)nn1,CN(C)C=O,Cc1ccccc1,,O,,val
US20140213578A1,NCCCN1c2ccccc2CCc2ccc(Cl)cc21.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(NCCCN1c2ccccc2CCc2ccc(Cl)cc21)c1ccccc1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20050070549A1,CC(C)(O)c1ccc2c(c1)C(=CCCBr)c1cccnc1CO2.COC(=O)CC1CNCCN1c1ccc(Cl)cc1>>COC(=O)CC1CN(CCC=C2c3cc(C(C)(C)O)ccc3OCc3ncccc32)CCN1c1ccc(Cl)cc1,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20160145267A1,CCOc1cc(F)c(Cn2nc(-c3nc(N)c(OCC(=O)OC(C)(C)C)c(N)n3)c(C)c2C2CC2)c(F)c1>>CCOc1cc(F)c(Cn2nc(-c3nc(N)c4c(n3)NC(=O)CO4)c(C)c2C2CC2)c(F)c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20130040930A1,CCOC(=O)c1ccc(N2CC(C)CS2(=O)=O)cc1>>CC1CN(c2ccc(C(=O)O)cc2)S(=O)(=O)C1,,C1CCOC1,,[Na+].[OH-],,val
US20050261277A1,COc1ccc2c(C(=O)c3ccc(OCCN4CCCCC4)cc3)c(-c3ccccc3C3OCCO3)sc2c1>>COc1ccc2c(C(=O)c3ccc(OCCN4CCCCC4)cc3)c(-c3ccccc3C=O)sc2c1,,C1CCOC1,ClCCl,Cl,O,val
US04292070,Nc1ccc(Cl)c(O)c1Cl.O=C1OC(=O)C2=C1CCCC2>>O=C1C2=C(CCCC2)C(=O)N1c1cc(O)c(Cl)cc1Cl,,O,,CC(=O)O,,val
US20040158065A1,CCC(O)N1CCOCC1.COc1ccc(CN(c2ccc(F)c(Cl)c2)c2ncnc3cc(F)c([N+](=O)[O-])cc23)cc1OC>>COc1ccc(CN(c2ccc(F)c(Cl)c2)c2ncnc3cc(OCCCN4CCOCC4)c([N+](=O)[O-])cc23)cc1OC,,C1CCOC1,CC(C)(C)O,CC(C)(C)[O-].[K+],,val
US20150259354A1,NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn(-c2cc([N+](=O)[O-])ccc2COC2CCCCO2)c1N>>NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn(-c2cc([N+](=O)[O-])ccc2CO)c1N,,CC#N,,Cl,,val
US20160108016A1,CC(C)[C@H]1COC(=O)N1.COc1cc(CC(=O)Cl)cc(OC)c1>>COc1cc(CC(=O)N2C(=O)OC[C@@H]2C(C)C)cc(OC)c1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20040242600A1,C1COCCO1.CCN(CC)CC.N#Cc1ccc(-c2cc3c(Cl)ncnc3[nH]2)cc1>>C[C@@H](Nc1ncnc2[nH]c(-c3ccc(C#N)cc3)cc12)c1ccccc1,,C1COCCO1,,,,val
US04568685,NCCCn1cncn1.O=c1[nH]c2ccccc2c(=O)o1>>Nc1ccccc1C(=O)NCCCn1cncn1,,CCO,,,,val
US20130231328A1,CC(C)(C)[Si](C)(C)OCC[C@H]1CCc2sc3ncnc(OC4CCC(N5CCOCC5)CC4)c3c21>>OCC[C@H]1CCc2sc3ncnc(OC4CCC(N5CCOCC5)CC4)c3c21,,CO,,Cl,,val
US20150073019A1,CCOC(=O)CC(=O)c1ccccc1.NNc1nc2c(Cl)cccc2s1>>O=c1cc(-c2ccccc2)[nH]n1-c1nc2c(Cl)cccc2s1,,CCO,,,,val
US20100190804A1,COc1ccc(Br)c(C#N)c1>>COc1ccc(Br)c(CN)c1,,C1CCOC1,,B,,val
US20130059863A1,CCOC(=O)C1(CCNc2ccc(Br)nc2C)CCN(C(=O)OC(C)(C)C)CC1>>Cc1nc(Br)ccc1N1CCC2(CCN(C(=O)OC(C)(C)C)CC2)C1=O,,C1CCOC1,CCOC(C)=O,CC(C)(C)[O-].[K+],,val
US04990424,C.C=C(C)C(=O)OCCCC.C=Cc1ccccc1>>C=CC=C.C=Cc1ccccc1,,Cc1ccccc1,,CO,ClCCl,val
US20100216791A1,NCCN1CCOCC1.O=Cc1ccc(Nc2ncc3cc(-c4ccncc4)ccc3n2)cc1>>c1cc(-c2ccc3nc(Nc4ccc(CNCCN5CCOCC5)cc4)ncc3c2)ccn1,CC(=O)O,CO,,[BH3-]C#N.[Na+],,val
US20120053173A1,CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(OC4CCSCC4)cc3c2C)C2CCCCC2)cc1>>Cc1c(C(Nc2ccc(C(=O)N(C)CCC(=O)O)cc2)C2CCCCC2)oc2ccc(OC3CCSCC3)cc12,,CCO,,[Na+].[OH-],,val
US03943154,N#CC=CS(=O)(=O)c1ccc(N)cc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>N#CC=CS(=O)(=O)c1ccc(NS(=O)(=O)C(F)(F)F)cc1,,ClC(Cl)Cl,,C1CN2CCN1CC2,,val
US20100056491A1,COC1CCN(c2cccc(S(=O)(=O)n3cc(C4=CCC(NC(=O)OC(C)(C)C)CC4)c4ncccc43)c2)C1>>COC1CCN(c2cccc(S(=O)(=O)n3cc(C4=CCC(N)CC4)c4ncccc43)c2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05763458,COc1ccc(Cl)c(NC(C)=O)c1.O=C(Cl)CCCCCl>>CC(=O)Nc1cc(O)c(C(=O)CCCCCl)cc1Cl,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100160291A1,O=C1C=C2OCCCn3ccc(c32)C1(O)c1cc2c(cc1O)OCO2>>O=C1C=C2OCCCn3ccc(c32)C1c1cc2c(cc1O)OCO2,,CC(Cl)Cl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20050020652A1,CCOC(=O)C(C)(C)Oc1ccc(OCCC2CNC(=O)N2C)cc1.CS(=O)(=O)c1ccc(CCl)cc1>>CCOC(=O)C(C)(C)Oc1ccc(OCCC2CN(Cc3ccc(S(C)(=O)=O)cc3)C(=O)N2C)cc1,,CN(C)C=O,O,Cl,[H-].[Na+],val
US04977273,COC(=O)Cl.O=C(NCCO)C(F)(F)Cc1c[nH]c([N+](=O)[O-])n1>>COC(=O)OCCNC(=O)C(F)(F)Cc1c[nH]c([N+](=O)[O-])n1,,ClC(Cl)Cl,,c1ccncc1,,val
US20150126449A1,CN(C)c1ccnc2nn3c(C4CCN(C(=O)OC(C)(C)C)CC4)cc(=O)[nH]c3c12.Cl>>CN(C)c1ccnc2nn3c(C4CCNCC4)cc(=O)[nH]c3c12.Cl,,C1COCCO1,CO,,,val
US20160016930A1,CI.Cc1cccc(C)c1NC(N)=S>>CSC(N)=Nc1c(C)cccc1C,,CCO,,,,val
US20140350262A1,CC1=CC(=O)OC(C)(C)O1.CN(CCc1ccccc1)C1CCc2ncc(N)cc2C1>>CC(=O)CC(=O)Nc1cnc2c(c1)CC(N(C)CCc1ccccc1)CC2,,Cc1ccccc1,,,,val
US20130035332A1,N#Cc1ccccc1-c1ccc2c(c1)sc(=O)n2CC1CCNCC1.O=C(Cl)OCc1ccccc1>>N#Cc1ccccc1-c1ccc2c(c1)sc(=O)n2CC1CCN(C(=O)OCc2ccccc2)CC1,,C1COCCO1,CO,CCN(C(C)C)C(C)C,,val
US04064246,COc1cccc(-c2nc(=O)n(C(C)C)c3cc(C)ccc23)c1>>Cc1ccc2c(-c3cccc(O)c3)nc(=O)n(C(C)C)c2c1,,O,,Br,,val
US04531139,CCCCc1ccc(NS(=O)(=O)c2ccccc2C(=O)OC)cc1>>CCCCc1ccc(NS(=O)(=O)c2ccccc2C(=O)O)cc1,,O,,Cl,[Na+].[OH-],val
US20070049632A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc(NN)cc1>>COc1ccc(NNC(=O)OC(C)(C)C)cc1,,CO,,CCN(CC)CC,Cl,val
US20140249135A1,CC1(C)OB(c2ccncc2N)OC1(C)C.COc1ccc(CNc2cc(I)cc(C(F)(F)F)n2)cc1OC>>COc1ccc(CNc2cc(-c3ccncc3N)cc(C(F)(F)F)n2)cc1OC,,COCCOC,,,,val
US20060111362A1,C=CCNc1ccncc1[N+](=O)[O-].Cl>>C=CCNc1ccnc(Cl)c1N,,O,,Cl[Sn](Cl)(Cl)Cl,,val
US20070213355A1,CC(C)(C)OC(=O)NCCc1ccc(Nc2c([N+](=O)[O-])cnc3ccc(Br)cc23)cc1>>CC(C)(C)OC(=O)NCCc1ccc(Nc2c(N)cnc3ccc(Br)cc23)cc1,[Ni],C1CCOC1,CO,,,val
US20160264551A1,CC(C)(C)OC(=O)Nc1ccc(C(=O)O)cc1.O=S(=O)(c1ccccc1)n1cc(-c2nc(NCC3CCCNC3)ncc2Cl)c2ccccc21>>CC(C)(C)OC(=O)Nc1ccc(C(=O)N2CCCC(CNc3ncc(Cl)c(-c4cn(S(=O)(=O)c5ccccc5)c5ccccc45)n3)C2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060183791A1,C=O.O=C(Nc1ccc(NCc2ccc(Cl)s2)cc1Cl)C(F)(F)F>>CN(Cc1ccc(Cl)s1)c1ccc(NC(=O)C(F)(F)F)c(Cl)c1,,CO,O,CC(=O)O,[BH3-]C#N.[Na+],val
US04564479,C=CC(=O)OCC.Cc1ccc(Br)cc1>>CCOC(=O)C=Cc1ccc(C)cc1,[Pd],,,,,val
US20140256729A1,CCOC(=O)/C=C/c1cncs1.C[S+](C)(C)=O>>CCOC(=O)[C@@H]1C[C@H]1c1cncs1,,CS(C)=O,,[H-].[Na+],,val
US04559354,Cn1ccnc1-c1ccc(OCC(O)CN(CCOc2ccc(OCc3ccccc3)c(C(N)=O)c2)Cc2ccccc2)cc1>>Cn1ccnc1-c1ccc(OCC(O)CNCCOc2ccc(O)c(C(N)=O)c2)cc1,,CO,,,,val
US20140328805A1,CC(=O)OC(C)=O.Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CN4)nc(N3CC4CC3C4)n2)cc1C(F)(F)F>>CC(=O)N1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nc(N2CC3CC2C3)n1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20090264648A1,BrCC1CC1.COC(=O)c1ccc(O)cc1C(F)(F)F>>COC(=O)c1ccc(OCC2CC2)cc1C(F)(F)F,,CC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20140323501A1,CC(N)=O.CCOC(=O)C(CCc1ccc(Sc2ccc(C(=O)COC(=O)C(C)C)cc2)cc1)(NC(C)=O)C(=O)OCC>>CCOC(=O)C(CCc1ccc(Sc2ccc(-c3coc(C(C)C)n3)cc2)cc1)(NC(C)=O)C(=O)OCC,,Cc1ccccc1C,,CCOCC,FB(F)F,val
US20090221575A1,CC(C)(C)OC(=O)N1CCc2ccc(O)cc2C1.CCCI>>CCCOc1ccc2c(c1)CN(C(=O)OC(C)(C)C)CC2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020055631A1,C=C(C)C.O=C(O)c1cc2cc(Br)ccc2s1>>CC(C)(C)OC(=O)c1cc2cc(Br)ccc2s1,,ClCCl,,O=S(=O)(O)O,,val
US20080255078A1,CCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(F)c(Br)c1.OB(O)c1ccoc1>>CCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(F)c(-c2ccoc2)c1,,COCCOC,,,,val
US20110319406A1,CCOC(CBr)OCC.Fc1ccccc1S>>CCOC(CSc1ccccc1F)OCC,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120027874A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ncc(Br)nc1-c1cc(-c2ccc(CCl)cc2)no1>>Nc1ncc(Br)nc1-c1cc(-c2ccc(CCl)cc2)no1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120322784A1,CC(C)(C)OC(=O)N1CCC(C2Cc3cc(Cl)ncc3O2)CC1.Oc1cnccn1>>CC(C)(C)OC(=O)N1CCC(C2Cc3cc(-n4ccncc4=O)ncc3O2)CC1,I[Cu]I,C1COCCO1,,,,val
US20130150364A1,Cl.ClC(Cl)Cl.FC(F)c1nc2ccccc2n1-c1cc(N2CCOCC2)nc(NCC2CCN(c3ccccc3)CC2)n1>>Cl.Cl.FC(F)c1nc2ccccc2n1-c1cc(N2CCOCC2)nc(NCC2CCN(c3ccccc3)CC2)n1,,C1COCCO1,,CO,,val
US04263168,CCCCCl.CCCCOCCCC.[Mg]>>CCCCCl.CCCCOCCCC.[Mg],,CCCCCCC,,II,,val
US20100093730A1,BrC(Br)(Br)Br.Cc1nc(-c2cccc(C(F)(F)F)c2)sc1CO>>Cc1nc(-c2cccc(C(F)(F)F)c2)sc1CBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160102083A1,BrC(Br)(Br)Br.C=CCCCC(O)C1CCN(C(=O)OC(C)(C)C)CC1>>C=CCCCC(Br)C1CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060142265A1,CCOC(=O)CN(CCCN1CCOCC1)Cc1cc(Br)cnc1N>>O=C1CN(CCCN2CCOCC2)Cc2cc(Br)cnc2N1,,CS(C)=O,O,[H-].[Na+],,val
US20100099718A1,ClCc1ccc(OCc2ccccc2)cc1.Nc1ncccc1-c1nc[nH]n1>>Nc1ncccc1-c1ncn(Cc2ccc(OCc3ccccc3)cc2)n1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20040019033A1,CSC(c1cc(F)c(C#N)cc1F)S(C)=O>>N#Cc1cc(F)c(C=O)cc1F,,C1CCOC1,,O,O=S(=O)(O)O,val
US20110111959A1,C1CCC2CNCCC2C1.CS(=O)Cl>>CS(=O)N1CCC2CCCCC2C1,,ClCCl,,CCN(CC)CC,,val
US20120165343A1,CCCC(=O)c1ccc(C(=O)OC)cc1>>CCCC(=O)c1ccc(C(=O)O)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20030134891A1,O=C1OCC=CCOC(=O)[C@H]2CCCN2C(=O)CCCCC(=O)N2CCC[C@H]12>>O=C1OCCCCOC(=O)[C@H]2CCCN2C(=O)CCCCC(=O)N2CCC[C@H]12,[Pd],CCOC(C)=O,,,,val
US20090048258A1,CCOc1ccc(C(=O)CCC(=O)O)cc1.Nc1cc(-c2ccccc2)c2ccccc2n1>>CCOc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccccc3)c3ccccc3n2)cc1,,CC#N,CN(C)C=O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20120172367A1,CNS(=O)(=O)CCCCC#N>>CNS(=O)(=O)CCCCCN,[Pd],CO,,,,val
US20120094968A1,CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(=O)(=O)Cl)N(C)C(=O)N1c1cccc(C(F)(F)F)c1.NCCO>>CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(=O)(=O)NCCO)N(C)C(=O)N1c1cccc(C(F)(F)F)c1,,C1CCOC1,,CCN(CC)CC,,val
US20140275172A1,BrBr.O=Cc1c(O)ccc2c1OCO2>>O=Cc1c(O)c(Br)cc2c1OCO2,,CO,,,,val
US20160068515A1,CC(C)n1ncn(-c2ccc(Br)cc2)c1=O.CC1(C)OB(c2cnc(N3CCC(c4nnc(C(F)(F)F)o4)CC3)c(C#N)c2)OC1(C)C>>CC(C)n1ncn(-c2ccc(-c3cnc(N4CCC(c5nnc(C(F)(F)F)o5)CC4)c(C#N)c3)cc2)c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20120214762A1,Brc1ccc2cn[nH]c2c1.COc1ncccc1Nc1ncnc(Cl)n1>>COc1ncccc1Nc1ncnc(-n2ncc3ccc(Br)cc32)n1,,CN(C)C=O,,[H-].[Na+],,val
US20100317624A1,CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(B(O)O)cn1.CCOC(=O)c1cn(C[C@@H]2CCNC2)c2ccc(I)cc2c1=O>>CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2ccc3c(c2)c(=O)c(C(=O)OCC)cn3C[C@@H]2CCNC2)cn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,Cl,O=C([O-])O.[Na+],val
US20110275805A1,Nc1ccc(N2CCOCC2)c(F)c1.O=C(Cl)OCc1ccccc1>>O=C(Nc1ccc(N2CCOCC2)cc1)OCc1ccccc1,,CC(C)=O,,O,O=C([O-])O.[Na+],val
US03971828,O=C(O)CNC(=O)Cc1ccc(Cl)cc1SC(=O)c1ccccc1>>O=C(O)CNC(=O)Cc1ccc(Cl)cc1S,,N,,,,val
US20140018343A1,CCOC(=O)C1CCCC(=O)C1.CCOC(=O)CC#N>>CCOC(=O)C(C#N)=C1CCCC(C(=O)OCC)C1,,Cc1ccccc1,,CC(=O)O,,val
US20100190761A1,CC(=O)OCc1nc(-c2ccc(C(C)(c3ccc(OCc4ccccn4)cc3)C(C)C)cc2)no1>>CC(C)C(C)(c1ccc(OCc2ccccn2)cc1)c1ccc(-c2noc(CO)n2)cc1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20100303928A1,CCOC(=O)c1nc(I)c2c(-c3ccc(OC)cc3)noc2c1O.N#C[Cu]>>CCOC(=O)c1nc(C#N)c2c(-c3ccc(OC)cc3)noc2c1O,,CCOC(C)=O,CN1CCCC1=O,Cl,[NH4+].[OH-],val
US20110039830A1,COc1ccc2c(c1)NC(=O)C2.Ic1ccccc1>>COc1ccc2c(c1)N(c1ccccc1)C(=O)C2,[Cu]I,CC#N,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US20090186879A1,COc1ccc(N2CCCn3c2nc2c(Cl)ccc(CO)c23)c(C)n1>>COc1ccc(N2CCCn3c2nc2c(Cl)ccc(C=O)c23)c(C)n1,,CS(C)=O,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20150045551A1,CCOC(=O)CC(=O)CCl.COc1ccnc(N)c1>>CCOC(=O)Cc1cn2ccc(OC)cc2n1,,CCO,,,,val
US05010078,COc1ccccc1N1CCN(CCCN)CC1.ClCCl.O=C(Cl)c1cc2ccccc2o1>>COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccc3o2)CC1.Cl.Cl,,ClCCl,,CCN(CC)CC,,val
US20100190766A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@@H](NC(c1ccccc1)(c1ccccc1)c1ccccc1)[C@@H](C)N>>COC(=O)[C@@H](NC(c1ccccc1)(c1ccccc1)c1ccccc1)[C@@H](C)NC(=O)OC(C)(C)C,,ClCCl,,,,val
US05071468,CCOCCO.CS(=O)(=O)Cl>>CCOCCOS(C)(=O)=O,,C1CCOC1,,c1ccncc1,,val
US20020111483A1,NN.O=S(=O)(c1ccccc1)c1ccc(Cl)cc1>>NNc1ccc(S(=O)(=O)c2ccccc2)cc1,CCN(CC)CC,O,OCCO,,,val
US20150291595A1,Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3Br)n(-c3ccccc3)c(=O)c12.OB(O)c1ccc2cc[nH]c2c1>>Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3ccc4cc[nH]c4c3)n(-c3ccccc3)c(=O)c12,,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050090498A1,CC(N)=S.O=C1Nc2ccc(C(=O)CCl)cc2C1=C1C=Cc2ccccc2N1>>Cc1nc(-c2ccc3c(c2)C(=C2C=Cc4ccccc4N2)C(=O)N3)cs1,,O,,CN(C)C=O,,val
US20080176871A1,Cc1cc(C)c(O)c(C)c1.Clc1nc(Cl)c2sccc2n1>>Cc1cc(C)c(Oc2nc(Cl)nc3ccsc23)c(C)c1,,C1CCOC1,O,[H-].[Na+],,val
US20120027874A1,CC(NC(=O)OC(C)(C)C)c1cccc(C(=O)O)c1>>CC(NC(=O)OC(C)(C)C)c1cccc(CO)c1,,C1CCOC1,,B,CSC,val
US20020028832A1,CC(C)(C)[Si](Oc1ccc(OC[C@@H](O)CNCCc2ccc(NC3CCN(C(=O)OCc4ccc(F)cc4)CC3)cc2)cc1)(c1ccccc1)c1ccccc1>>O=C(OCc1ccc(F)cc1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1,,CO,ClC(Cl)Cl,,,val
US07371773B2,CC(=O)OC(C)=O.COc1ccc(/C(C#N)=C/c2cccc(N)c2)cc1OC>>COc1ccc(C(C#N)=Cc2cccc(NC(C)=O)c2)cc1OC,,c1ccncc1,,,,val
US05723479,COC(=O)COc1cc(OC)ccc1C=O>>COC(=O)c1cc2ccc(OC)cc2o1,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,,val
US20130261111A1,C=CCN1CC2CON(C(=S)NC(=O)c3ccccc3)C2(c2ccc(F)s2)C1>>C=CCN1CC(CO)C(NC(=S)NC(=O)c2ccccc2)(c2ccc(F)s2)C1,[Zn],CC(=O)O,,,,val
US20090088425A1,CC(c1ccc(O)cc1Cl)C(O)(c1ccc(=O)n(C)c1)C(F)(F)F.N#Cc1ccc(F)c(F)c1>>CC(c1ccc(Oc2ccc(C#N)cc2F)cc1Cl)C(O)(c1ccc(=O)n(C)c1)C(F)(F)F,,CC(=O)N(C)C,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20040014940A1,CC(C)CC(CNC(=O)OC(C)OC(=O)C(C)C)CC(=O)OCc1ccccc1>>CC(C)CC(CNC(=O)OC(C)OC(=O)C(C)C)CC(=O)O,[Pd],CCO,,,,val
US20100041658A1,COc1cc(C(F)C(F)(F)F)ccc1Oc1cccc(F)n1>>COc1cc(C(F)=C(F)F)ccc1Oc1cccc(F)n1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120208823A1,COc1ccc(Nc2ccc(C#N)c(F)c2)c(C(F)(F)F)c1>>COc1ccc(Nc2ccc(CN)c(F)c2)c(C(F)(F)F)c1,[Ni],N,,,,val
US09024027B2,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COCCNCCN(c1ccc2c(c1)C(=O)N(CC(=O)OCc1ccccc1)C2=O)S(C)(=O)=O>>COCCN(CCN(c1ccc2c(c1)C(=O)N(CC(=O)OCc1ccccc1)C2=O)S(C)(=O)=O)C(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20130345181A1,CNC.COc1cc(CBr)ccc1[N+](=O)[O-]>>COc1cc(CN(C)C)ccc1[N+](=O)[O-],,C1CCOC1,,CCN(CC)CC,,val
US20100316601A1,BrB(Br)Br.COc1c(N)cc(C)cc1-c1ccc(C(=O)O)o1>>Br.Cc1cc(N)c(O)c(-c2ccc(C(=O)O)o2)c1,,ClCCl,,,,val
US08178536B2,Cc1cnc(Cl)c(NC(=O)c2ccccc2[N+](=O)[O-])c1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>Cc1cnc2sc(-c3ccccc3[N+](=O)[O-])nc2c1,,c1ccncc1,,Cc1ccccc1C,,val
US20090182023A1,CC(=O)NCCC1CCc2ccc(NC(=O)C3CC3)c(O)c21>>CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20150025093A1,CNC1CCC(Nc2ncnc3sc4c(c23)CCC4)CC1.O=C(CCl)N1CCOCC1>>CN(CC(=O)N1CCOCC1)C1CCC(Nc2ncnc3sc4c(c23)CCC4)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100292206A1,CC(C)(C)c1ccccc1OC1CNC1.O=C(Cl)c1ccccn1>>CC(C)(C)c1ccccc1OC1CN(C(=O)c2ccccn2)C1,,c1ccncc1,,Cl,,val
US04124619,C.CC(=O)OCC=CCOC(C)=O>>C=C(C=O)CCOC(C)=O,[Rh],c1ccccc1,,,,val
US20040180912A1,COc1ccc(Nc2ccc(OC)cc2)cc1.N#C[O-]>>COc1ccc(N(C(N)=O)c2ccc(OC)cc2)cc1,,CC(=O)O,O,[Na+].[OH-],,val
US20100104532A1,CO[C@H]1O[C@@H]2COC(C)(C)O[C@@H]2[C@H]1OS(=O)(=O)c1ccc(C)cc1>>CO[C@H]1O[C@H](CO)[C@H](O)[C@H]1OS(=O)(=O)c1ccc(C)cc1,,CC(=O)O,O,,,val
US20150152108A1,Cc1ccc(-c2cc(C)c3c(n2)N[C@H]2CCN3C2)cn1.O=C(Nc1cccnc1)Oc1ccccc1>>Cc1ccc(-c2cc(C)c3c(n2)N(C(=O)Nc2cccnc2)[C@H]2CCN3C2)cn1,,C1CCOC1,,CCOC(C)=O,,val
US20150291624A1,CC(C)(C)OC(=O)c1c[nH]c2ccc(F)cc12.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)c1cn(S(C)(=O)=O)c2ccc(F)cc12,,C1CCOC1,,CCN(CC)CC,O,val
US06114390,CN.N#Cc1ccc(CS(=O)(=O)Cl)cc1>>CNS(=O)(=O)Cc1ccc(C#N)cc1,,C1CCOC1,,,,val
US20090099190A1,CCN1C(=O)N(c2ccc(F)c([N+](=O)[O-])c2)Cc2cnc(N(C)OC)cc21>>CCN1C(=O)N(c2ccc(F)c(N)c2)Cc2cnc(NC)cc21,[Pd],CO,,[H][H],,val
US20090156612A1,CC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C.NCc1ccccc1>>CC(NCc1ccccc1)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C,,CC(=O)O,ClCCCl,O=C([O-])O.[Na+],,val
US20140249104A1,CC(C)(C)[S@@](=O)N[C@@](C)(CC=O)c1cccc(F)c1Cl.C[Si](C)(C)C(F)(F)F>>CC(C)(C)[S@@](=O)N[C@@](C)(C[C@H](O)C(F)(F)F)c1cccc(F)c1Cl,,C1CCOC1,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130062598A1,CCCCC(C)c1ccc2cc(OS(=O)(=O)C(F)(F)F)c(SC)cc2c1.CCCC[Sn](/C=C/[Sn](CCCC)(CCCC)CCCC)(CCCC)CCCC.CSc1ccccc1OS(=O)(=O)C(F)(F)F>>CCCCC(C)c1ccc2cc(/C=C/c3ccccc3SC)c(SC)cc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,,,val
US20160176896A1,CO.O=C(O)C(F)(F)OCCN(Cc1ccccc1)Cc1ccccc1>>COC(=O)C(F)(F)OCCN(Cc1ccccc1)Cc1ccccc1,,CO,Cc1ccccc1,C[Si](C)(C)C=[N+]=[N-],,val
US20100273845A1,CC(CCO)[C@@H](O[N+](=O)[O-])[C@@H](C)O[N+](=O)[O-].CCOc1nc2cccc(C(=O)OC(C)(C)OC(=O)Oc3ccc([N+](=O)[O-])cc3)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCOc1nc2cccc(C(=O)OC(C)(C)OC(=O)OCCC(C)[C@@H](O[N+](=O)[O-])[C@@H](C)O[N+](=O)[O-])c2n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,ClCCl,,,,val
US20140275199A1,COC(=O)C1(N)CCC(OC)(C(F)(F)F)CC1.Cc1ccc(-c2ccc(Cl)cc2)cc1CC(=O)Cl>>COC(=O)C1(NC(=O)Cc2cc(-c3ccc(Cl)cc3)ccc2C)CCC(OC)(C(F)(F)F)CC1,,ClCCl,,CCN(CC)CC,,val
US20160115126A1,Cc1[nH]c2c(C(N)=O)ccc(Br)c2c1C>>Cc1[nH]c2c(C#N)ccc(Br)c2c1C,,C1CCOC1,,O=P(Cl)(Cl)Cl,,val
US05298652,CCCCCCCCCCCCCCCCCCOc1ccc(OCc2ccccc2)c(C(=O)OC)c1>>CCCCCCCCCCCCCCCCCCOc1ccc(OCc2ccccc2)c(C(=O)O)c1,,CO,,[Na+].[OH-],,val
US05049669,CC(C)CCCNC(=S)c1ccc2c(c1)N(C(C)CN1CCCC1)c1ccccc1S2.Cl.O>>Cl.NC(=O)c1ccc2c(c1)Nc1ccccc1S2,,O,,CC(=O)O,,val
US20080096861A1,CN(Cc1nc2ccccc2n1CCNC(=O)OC(C)(C)C)C1CCCc2cccnc21>>CN(Cc1nc2ccccc2n1CCN)C1CCCc2cccnc21,,CO,,C1COCCO1,Cl,val
US20090137595A1,Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1.O=S(=O)(O)c1ccccc1>>Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1.O=S(=O)(O)c1ccccc1,,CCO,,O,,val
US20150259366A1,COC(=O)c1cc(N(Cc2ccc(Br)cc2)C(=O)c2ccc(Oc3ccccc3)cc2)ccc1O>>O=C(O)c1cc(N(Cc2ccc(Br)cc2)C(=O)c2ccc(Oc3ccccc3)cc2)ccc1O,,CC#N,,,,val
US20150065507A1,Cc1ccc(N)nc1.Cc1noc(C)c1COc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(NS(=O)(=O)c2ccc(OCc3c(C)noc3C)cc2)nc1,,c1ccncc1,,,,val
US20160222033A1,Cc1sc2nc(CC(N)=S)cc(=O)n2c1Br.O=C(CBr)C(F)(F)F>>Cc1sc2nc(Cc3nc(C(F)(F)F)cs3)cc(=O)n2c1Br,,CCO,,,,val
US04261997,CCOC(=O)c1cc2n(C)c3ccc(F)cc3c(=O)n2n1>>Cn1c2ccc(F)cc2c(=O)n2nc(C(=O)O)cc12,,CO,,[Na+].[OH-],,val
US04612314,CCCCCCCC(=O)OCC(COC(=O)CCCCCCC)OCn1cnc2c(=O)[nH]c(N)nc21>>CCCCCCCC(=O)OCC(COC(=O)CCCCCCC)OCn1cnc2c(=O)[nH]c(N)nc21,,CCOCC,,Cl,O=C([O-])[O-].[K+].[K+],val
US05036075,CC(CCl)CN1c2cccc3cccc(c23)S1(=O)=O.Fc1ccc(N2CCNCC2)cc1>>CC(CN1CCN(c2ccc(F)cc2)CC1)CN1c2cccc3cccc(c23)S1(=O)=O,,Cc1ccccc1,,CCN(CC)CC,[I-].[Na+],val
US20130184479A1,COc1cc(Br)cc(OC)c1.Cc1cc(C)cc(P(Cl)c2cc(C)cc(C)c2)c1.OO>>COc1cc(OC)cc(P(=O)(c2cc(C)cc(C)c2)c2cc(C)cc(C)c2)c1,II,C1CCOC1,O,[Mg],,val
US20160000760A1,CS(=O)(=O)c1ccc(B(O)O)cc1.Nc1ccc(Br)c(Cl)c1>>CS(=O)(=O)c1ccc(-c2ccc(N)cc2Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20100324047A1,Clc1ncnc2[nH]ccc12.OB(O)c1cccnc1F>>Fc1ncccc1-c1ncnc2[nH]ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20060270663A1,CC(=O)Nc1ccc(C(=O)CCCl)cc1.O=C1NC(=O)c2ccccc21>>NC(=O)Cc1ccc(C(=O)CCN2C(=O)c3ccccc3C2=O)cc1,,CN(C)C=O,,[K],,val
US06300363B1,CCOC(=O)n1c(C(=O)c2ccccc2)c(NC(=O)CCl)c2ccc(Cl)cc21.CNC>>CN(C)CC(=O)Nc1c(C(=O)c2ccccc2)[nH]c2cc(Cl)ccc12,,CN(C)C=O,,Cl,O,val
US04240820,Cc1oc(N)c(C#N)c1C.O=C(Cl)CCl>>Cc1oc(NC(=O)CCl)c(C#N)c1C,,Cc1ccccc1,,Cl,,val
US03994920,CC(N)C(C)N.O=C(O)c1ccccc1C(=O)c1ccccc1>>CC1NC2(c3ccccc3)c3ccccc3C(=O)N2C1C,,Cc1ccccc1,,,,val
US04900752,CC1(C)Oc2cc3nonc3cc2C(N)C1O.O=C(Cl)CCl>>CC1(C)Oc2cc3nonc3cc2C(NC(=O)CCl)C1O,,ClCCl,,CCN(CC)CC,,val
US20060122168A1,CCOC(=O)C(C)(O)C(=O)NCC(F)(F)C(F)(F)F>>CC(O)(C(=O)O)C(=O)NCC(F)(F)C(F)(F)F,,C1CCOC1,O,[Li+].[OH-],,val
US20100022541A1,CC(=O)Nc1ccc(S(=O)(=O)N=[N+]=[N-])cc1.CCOC(=O)CC(=O)COCc1ccccc1>>CCOC(=O)C(=[N+]=[N-])C(=O)COCc1ccccc1,,CC#N,,CCN(CC)CC,,val
US20130116230A1,NC(=O)c1cccc(C(F)(F)F)c1CC(=O)NC1(CF)CCNC1.O=C1CCC(O)(c2ccccc2)CC1>>NC(=O)c1cccc(C(F)(F)F)c1CC(=O)NC1(CF)CCN(C2CCC(O)(c3ccccc3)CC2)C1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20020013310A1,N[C@H]1CCN(Cc2ccc3ccnc(Cl)c3c2)C1=O.O=S(=O)(Cl)c1cc2ncccc2s1>>O=C1[C@@H](NS(=O)(=O)c2cc3ncccc3s2)CCN1Cc1ccc2ccnc(Cl)c2c1,,CC#N,,CCN(CC)CC,Cl,val
US20160021879A1,CCCCCC/C=C\CCCCCCCC=O.COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCCC/C=C\CCCCCCC/C=C/C(=O)OC,,ClCCl,,CCOCC,,val
US20090299072A1,CCOC(=O)C(CC(C)C)c1cc(I)c(OCC2CC2)c(-c2ccc(C(F)(F)F)cc2)c1.N#C[Cu]>>CCOC(=O)C(CC(C)C)c1cc(C#N)c(OCC2CC2)c(-c2ccc(C(F)(F)F)cc2)c1,,CN1CCCC1=O,,,,val
US04344943,CC(=O)OC(C)=O.OCCn1cccc1>>CC(=O)OCCn1cccc1,,O,,c1ccncc1,,val
US20110319392A1,C1CCOC1.C=CCOC(=O)Cl.Nc1cc(C(=O)[O-])ccc1F>>C=CCOC(=O)Nc1cc(C(=O)OCC)ccc1F,,C1CCOC1,,c1ccncc1,,val
US20100075995A1,CCC[C@@H](C)Nc1nc(N)c2nc(Br)n(C3CCCCO3)c2n1.CO>>CCC[C@@H](C)Nc1nc(N)c2nc(OC)n(C3CCCCO3)c2n1,,CO,,C[O-].[Na+],,val
US05039672,CC(=O)c1cc(F)ccc1O.CCCC(=O)OCC>>CCCc1cc(=O)c2cc(F)ccc2o1,,C1CCOC1,,Cl,[H-].[Na+],val
US20080194647A1,Cl.Fc1ccc(C#Cc2cncc(Br)c2)cc1>>Cl.Fc1ccc(C#Cc2cncc(Br)c2)cc1,,CCOCC,,,,val
US20030225133A1,NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc([N+](=O)[O-])cn1>>NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(N)cn1,O=[Pt]=O,CCO,,,,val
US20030045552A1,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>O=C1CCC(N2C(=O)c3cccc(NC(=O)c4ccc([N+](=O)[O-])cc4)c3C2=O)C(=O)N1,,C1CCOC1,,CO,,val
US20020173654A1,CC(C)(C)OC(=O)NCCN.O=[N+]([O-])c1cnc2c(c1)N(Cl)CC=C2>>CC(C)(C)OC(=O)NCCNc1c([N+](=O)[O-])cnc2cccnc12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05051509,N[C@H]1CCCNC1.O=C(O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O>>N[C@H]1CCCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C1,,CC#N,,CCN(CC)CC,,val
US20040029874A1,CC(C)(C)OC(=O)N1CCNCC1.COC(=O)c1ccccc1N=C=O>>COC(=O)c1ccccc1NC(=O)N1CCN(C(=O)OC(C)(C)C)CC1,,ClCCCl,,,,val
US05348978,CCOC(=O)[C@H](CCO)OC(C)=O.Oc1ccccc1>>CCOC(=O)[C@H](CCOc1ccccc1)OC(C)=O,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110275801A1,Cc1cc([C@@H]2CC[C@@H](c3nnc4n3-c3ccc(Cl)cc3CNC4)CC2)no1.O=S(=O)(OCC(F)F)C(F)(F)F>>Cc1cc([C@@H]2CC[C@@H](c3nnc4n3-c3ccc(Cl)cc3CN(CC(F)F)C4)CC2)no1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100093740A1,COC(=O)CBr.Cc1ccc(O)cc1C>>COC(=O)COc1ccc(C)c(C)c1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05654316,CS(=O)(=O)Cl.O=C(CC(CCO)c1ccc(Cl)c(Cl)c1)Nc1ccc(Cl)cc1>>CS(=O)(=O)OCCC(CC(=O)Nc1ccc(Cl)cc1)c1ccc(Cl)c(Cl)c1,,ClCCl,,CCN(CC)CC,,val
US20150307463A1,CCOC(=O)c1cc(-c2ccc(OC)cc2)no1>>CCOC(=O)c1cc(-c2ccc(O)cc2)no1,,ClCCl,,BrB(Br)Br,,val
US20130115190A1,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2ncc(OC)c3ccccc23)CN1C(=O)OC(C)(C)C)C(=O)NS(=O)(=O)C1CC1>>C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2ncc(OC)c3ccccc23)CN1)C(=O)NS(=O)(=O)C1CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110112096A1,Cc1cc(Nc2nc(Nc3cc(C)c(C4CCC(=O)CC4)cc3C)ncc2Cl)n[nH]1.NO>>Cc1cc(Nc2nc(Nc3cc(C)c(C4CCC(=NO)CC4)cc3C)ncc2Cl)n[nH]1,,CO,,Cl,CC(=O)[O-].[Na+],val
US20140148433A1,CCOC(=O)c1cnc(-c2nn(Cc3ccccc3F)c3ncccc23)nc1N>>Nc1nc(-c2nn(Cc3ccccc3F)c3ncccc23)ncc1C(=O)O,,C1COCCO1,,Cl,[Na+].[OH-],val
US04623662,CCCCc1ccc(CNCCCCCCO)cc1.Cc1ccc(N=C=O)c(C)c1>>CCCCc1ccc(CN(CCCCCCO)C(=O)Nc2ccc(C)cc2C)cc1,,CCCCCC,,,,val
US20110301162A1,Clc1nnc(-c2ccccc2)c2ccccc12.Nc1ccc(O)cc1>>Cl.Oc1ccc(Nc2nnc(-c3ccccc3)c3ccccc23)cc1,,c1ccccc1,,CCOCC,,val
US05569653,CCN(CC)CC.Cl.ClC(Cl)Cl.ClCCl.NCCN1CCC(c2noc3cc(F)ccc23)CC1.O=C(Cl)c1cccnc1>>CC(C)OC(C)C.Cl.Cl.O,,ClC(Cl)Cl,ClCCl,,,val
US20120302540A1,CC(C)(C)OC(=O)NC(C)(C)C(=O)N1C(=O)CCC1=O.C[C@H](OCc1ccccc1)[C@@H](N)C(=O)O>>C[C@H](OCc1ccccc1)[C@@H](NC(=O)C(C)(C)NC(=O)OC(C)(C)C)C(=O)O,,C1CCOC1,,O,,val
US20130059848A1,CC(C)(C)OC(=O)NN.CC1(C)CC(=O)CC(C)(C)C1>>CC1(C)CC(=NNC(=O)OC(C)(C)C)CC(C)(C)C1,,CN(C)C=O,,O,,val
US20120178934A1,CC#CCOc1ccc(C(=O)Cl)cc1.COC(=O)C(CN)(C(=O)OC)N1CCN(C(=O)OC(C)(C)C)CC1>>CC#CCOc1ccc(C(=O)NCC(C(=O)OC)(C(=O)OC)N2CCN(C(=O)OC(C)(C)C)CC2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20140288040A1,CCC(N)c1ccc(F)c(Oc2ccccc2)c1F.Cl.Clc1ccncc1>>CCC(Nc1ccncc1)c1ccc(F)c(Oc2ccccc2)c1F.Cl,,CN1CCCC1=O,,,,val
US20140364412A1,CC(C)[Si](Oc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)cc1Cl)(C(C)C)C(C)C>>CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)n(-c2ccc(O)c(Cl)c2)n1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04657929,COC(Cl)Cl.COc1ccc(CCNC(=O)C(F)(F)F)cc1>>COc1ccc(CCNC(=O)C(F)(F)F)cc1C=O,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US05646173,C[C@@H](O)CN.Cc1ccc2c(c1)C(=O)C(CC=O)C2>>Cc1ccc2c(c1)-c1c(ccn1C[C@@H](C)O)C2,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,O,,val
US04349674,CNC(=S)NC.Cc1nc2ccccc2nc1Cl>>CN=C(NC)Sc1nc2ccccc2nc1C.Cl,,CO,,C,,val
US20090163512A1,COC(=O)C(C)(C)Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(C)ccc2OC)C12C(=O)Nc1cc(Cl)ccc12>>COc1ccc(C)cc1C1NC(=O)CC(c2cc(Cl)ccc2OC(C)(C)C(=O)O)C12C(=O)Nc1cc(Cl)ccc12,,CO,,O,[Na+].[OH-],val
US20130065861A1,CC(C)(C)O.CC(C)(C)OC(=O)[C@H](CS)NC(=O)OCc1ccccc1.O=C([O-])c1ccccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)[C@H](CSC[C@@H](O)CO)NC(=O)OCc1ccccc1,,CC(C)(C)O,,[Na+].[OH-],,val
US06583156B1,Cc1c(C(F)(F)F)nc2c(C(F)(F)F)cccc2c1O.O=P(Br)(Br)Br>>Cc1c(C(F)(F)F)nc2c(C(F)(F)F)cccc2c1Br,,Cc1ccccc1,,,,val
US20100280013A1,C/C=C\c1cc(C(=O)OC)ccc1N1CCN(C(=O)OC(C)(C)C)CC1>>C/C=C\c1cc(C(=O)O)ccc1N1CCN(C(=O)OC(C)(C)C)CC1,,CO,,Cl,[Na+].[OH-],val
US20040058964A1,CC(=O)OCc1cc(O)cc(=O)n1-c1cccc(C(N)=O)c1.Fc1ccc(CBr)c(F)c1>>CC(=O)OCc1cc(OCc2ccc(F)cc2F)cc(=O)n1-c1cccc(C(N)=O)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040023989A1,CC(C)c1[nH]nc(C(=O)O)c1[N+](=O)[O-].CN(C)C=O.ClCCl>>NC(=O)c1n[nH]c(C2CCCC2)c1[N+](=O)[O-],,ClCCl,,O=C(Cl)C(=O)Cl,,val
US05962462,C=CCC(CN(C)S(=O)(=O)c1ccccc1)c1cccc(Cl)c1.OO>>CN(CC(CCCO)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1,,C1CCOC1,,B1C2CCCC1CCC2,[Na+].[OH-],val
US20160083370A1,Cc1cc(C)nc(N2CCNCC2)n1.Cc1ccc(S(=O)(=O)OCCCCc2c[nH]c3ccc(Cl)cc23)cc1>>Cc1cc(C)nc(N2CCN(CCCCc3c[nH]c4ccc(Cl)cc34)CC2)n1,,CC#N,,[I-].[K+],,val
US05478858,Cc1cc(N)c(C)c2[nH]cnc12.S=C(Oc1ccccn1)Oc1ccccn1>>Cc1cc(N=C=S)c(C)c2[nH]cnc12,CN(C)c1ccncc1,CO,ClCCl,,,val
US20050277639A1,Cc1cc(C(=O)C=CN(C)C)cc(C)n1.Nc1n[nH]cc1C(=O)c1ccccn1>>Cc1cc(-c2ccnc3c(C(=O)c4ccccn4)cnn23)cc(C)n1,,CC(=O)O,,O,,val
US20120283222A1,CC(C)(C)OC(=O)CN(CC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)CN(N)CC(=O)OC(C)(C)C,[Pd],CO,,,,val
US20120040998A1,COC(=O)N1C[C@@H](c2nc(-c3ccc(F)cc3)co2)CC[C@H]1C>>C[C@@H]1CC[C@H](c2nc(-c3ccc(F)cc3)co2)CN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120213729A1,CC(C)(C)OC(=O)c1ccc(Nc2nc(Cl)nc(OCC(F)(F)F)n2)cc1.NC1(c2ccc(Cl)cc2)CC1>>CC(C)(C)OC(=O)c1ccc(Nc2nc(NC3(c4ccc(Cl)cc4)CC3)nc(OCC(F)(F)F)n2)cc1,,C1CCOC1,,,,val
US20130225620A1,Nc1c(Br)cc(F)cc1[N+](=O)[O-]>>Nc1cc(F)cc(Br)c1N,,CCO,,Cl[Sn]Cl,,val
US20090247514A1,O=Cc1ccc2cc3c(cc2n1)C[C@]1(C3)C(=O)Nc2ncccc21>>OCc1ccc2cc3c(cc2n1)C[C@@]1(C=Nc2ncccc21)C3,,CO,CS(C)=O,[BH4-].[Na+],,val
US05856334,CI.OC1CCn2c(CCc3ccccc3)nc3cccc1c32>>COC1CCn2c(CCc3ccccc3)nc3cccc1c32,,C1CCOC1,,O,[H-].[Na+],val
US20120172351A1,COC(=O)C[C@@H]1COc2cc(NC3COc4c(-c5c(C)nn(C(F)F)c5C)cccc43)ccc21>>Cc1nn(C(F)F)c(C)c1-c1cccc2c1OCC2Nc1ccc2c(c1)OC[C@H]2CC(=O)O,,C1CCOC1,CO,[Na+].[OH-],,val
US20100047367A1,COC(=O)c1c(O)c2cc(Br)cn2n(Cc2ccc(C(F)(F)F)cc2)c1=O.OB(O)c1ccccc1>>COC(=O)c1c(O)c2cc(-c3ccccc3)cn2n(Cc2ccc(C(F)(F)F)cc2)c1=O,,CC(=O)N(C)C,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20040054172A1,Cc1cc(I)ccc1Nc1cc(F)ccc1C(=O)NOCCCO[Si](C)(C)C(C)(C)C>>Cc1cc(I)ccc1Nc1cc(F)ccc1C(=O)NOCCCO,,CO,,O,O=S(=O)(O)O,val
US20080114007A1,CCN1CCCC1CN.O=C(Cl)c1cccc([N+](=O)[O-])c1>>CCN1CCCC1CNC(=O)c1cccc(N)c1,,ClCCl,,CC(C)NC(C)C,,val
US20040072880A1,CCN(CC)CC.COc1ncccc1C(=O)O.ClCCl.N[C@@H]1C[C@H]1c1ccccc1>>COc1ncccc1C(=O)NCC1(c2ccccc2)CCCCC1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20150274708A1,Cn1cc([N+](=O)[O-])c(C(N)=O)n1>>Cn1cc(N)c(C(N)=O)n1,[Pd],CCO,,[H][H],,val
US20130245021A1,CN(C(=O)OC(C)(C)C)[C@H]1CCN(c2ccc3ncc(Br)n3n2)C1.COc1ncccc1B(O)O>>COc1ncccc1-c1cnc2ccc(N3CC[C@H](N(C)C(=O)OC(C)(C)C)C3)nn12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20150038438A1,C=CCCCC(O)c1ccc(N(C)C)cc1C=C.CC(C)(C)[Si](C)(C)Cl>>C=CCCCC(O[Si](C)(C)C(C)(C)C)c1ccc(N(C)C)cc1C=C,,ClCCl,,c1c[nH]cn1,,val
US20070037807A1,CC(=O)c1ccccc1.Cc1ccc(C=O)cc1>>Cc1ccc(/C=C/C(=O)c2ccccc2)cc1,,CCO,CCOC(C)=O,[Na+].[OH-],,val
US20160130254A1,CCN(c1ccc(C#N)c(C(F)(F)F)c1)C1CC=C(c2c[nH]cn2)C1.Cc1ccc(S(=O)(=O)Cl)cc1>>CCN(c1ccc(C#N)c(C(F)(F)F)c1)C1CC=C(c2cn(S(=O)(=O)c3ccc(C)cc3)cn2)C1,,ClCCl,O,,,val
US20140235612A1,CCOC(=O)C(=O)Cl.NC1CC1>>CCOC(=O)C(=O)NC1CC1,,C1CCOC1,,CCN(CC)CC,,val
US04929618,BrCCCSc1nc2ccccc2s1.Clc1ccc(C(OC2CCNCC2)c2ccccn2)cc1>>Clc1ccc(C(OC2CCN(CCCSc3nc4ccccc4s3)CC2)c2ccccn2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050203153A1,CCCNc1ccc([N+](=O)[O-])cc1-c1nc2cc(-c3cc4ccccc4s3)ccc2o1>>CCCNc1ccc(N)cc1-c1nc2cc(-c3cc4ccccc4s3)ccc2o1,[Zn],,,,,val
US20090192145A1,C1COCCO1.CC1(C)OB(C2=CCCc3cc(C#N)ccc32)OC1(C)C.O=C([O-])Cn1cncc1I>>CCOC(=O)Cn1cncc1C1=CCCc2cc(C#N)ccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O,O=C([O-])[O-].[Na+].[Na+],val
US20110053905A1,Cc1ccc(F)c(N)c1.O=C(O)c1ccc(F)c(Oc2ccnc(Cl)c2)c1>>Cc1ccc(F)c(NC(=O)c2ccc(F)c(Oc3ccnc(Cl)c3)c2)c1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110257174A1,ClCCl.O=C(O)c1cccc2c(=O)cc(-c3cccc(C(F)(F)F)c3)oc12>>O=C(Cl)c1cccc2c(=O)cc(-c3cccc(C(F)(F)F)c3)oc12,CN(C)C=O,,,,,val
US20100056374A1,CCCI.Oc1cc(CCNc2ncnc3c(F)ccc(F)c23)ccc1Oc1cc(C(F)(F)F)ccn1>>CCCOc1cc(CCNc2ncnc3c(F)ccc(F)c23)ccc1Oc1cc(C(F)(F)F)ccn1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US05922771,CC(=O)Cl.COc1ccc2c(c1)/C(=C/CN)CC2>>COc1ccc2c(c1)/C(=C/CNC(C)=O)CC2,,C1CCOC1,O,CCN(CC)CC,,val
US06756380B1,CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1nc(COS(C)(=O)=O)ncc1-c1ccccc1Cl.CNC>>CN(C)Cc1ncc(-c2ccccc2Cl)c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1,,O,,ClCCl,,val
US20090044345A1,CCOC(=O)c1cc(O)cc(-c2cc(Cl)ccn2)n1>>OCc1cc(O)cc(-c2cc(Cl)ccn2)n1,,CO,COCCOC,Cl,[Na+].[OH-],val
US20140315881A1,CCOC(=O)Cc1ccc(O)nc1.O=C1CCC(=O)N1I>>CCOC(=O)Cc1cnc(O)c(I)c1,,CC#N,,,,val
US20100204196A1,COCC(=O)N1CCc2cc(OC)c([N+](=O)[O-])cc21>>COCC(=O)N1CCc2cc(OC)c(N)cc21,Cl[Ni]Cl,C1CCOC1,,CO,[BH4-].[Na+],val
US20120190649A1,CC(C)(C)C1CCC(Oc2ccc3cc(Br)ccc3c2)CC1.CON(C)C(=O)C(F)(F)F>>CC(C)(C)C1CCC(Oc2ccc3cc(C(=O)C(F)(F)F)ccc3c2)CC1,,C1CCOC1,,,,val
US20110224155A1,N#Cc1c(N)cccc1C1CC1.NS(=O)(=O)Cl>>NC1=NS(=O)(=O)Nc2cccc(C3CC3)c21,,CC(=O)N(C)C,O,Cl,[Na+].[OH-],val
US05932551,CCCc1ccc(C(=O)C[C@H](NC(=O)C(F)(F)F)C(=O)O)cc1>>CCCc1ccc(CC[C@H](NC(=O)C(F)(F)F)C(=O)O)cc1,[Pd],CCOC(C)=O,,CC(=O)O,[H][H],val
US20100130446A1,CSc1ccc(C(O)(CC2CCOCC2)c2c(Cl)nc(-c3ccccn3)n2COCC[Si](C)(C)C)cc1Cl>>CSc1ccc(/C(=C\C2CCOCC2)c2[nH]c(-c3ccccn3)nc2Cl)cc1Cl,,CCO,,Cl,O=C([O-])O.[Na+],val
US05811431,C=O.COC(=O)C(CNCc1ccc(Cl)c(Cl)c1)NC(=O)OC(C)(C)C>>COC(=O)C(CN(C)Cc1ccc(Cl)c(Cl)c1)NC(=O)OC(C)(C)C,,CC#N,CC(=O)O,[BH3-]C#N.[Na+],,val
US20120114624A1,CCOC(=O)C(=O)C(C)Br.Nc1ncc(C(F)(F)F)cc1Cl>>CCOC(=O)c1nc2c(Cl)cc(C(F)(F)F)cn2c1C,,C1COCCO1,,,,val
US20120214735A1,CCOC(=O)C(OC(C)C)c1csc(N(Cc2ccc(OC)cc2)C(=O)OC(C)(C)C)n1>>CCOC(=O)C(OC(C)C)c1csc(N)n1,,O=C(O)C(F)(F)F,,,,val
US20110201635A1,C[Si](C)(C)CN.O=Cc1cccc(Cl)c1>>C[Si](C)(C)C/N=C/c1cccc(Cl)c1,,ClCCl,,O,,val
US04064138,F.N[C@@H](Cc1c[nH]cn1)C(=O)O.O=P(O)(O)O>>F.N[C@@H](Cc1c[nH]cn1)C(=O)O.O=P(O)(O)O,,OCC(O)CO,,,,val
US20160272596A1,COc1ccc2cc(Br)ccc2c1CN1C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)CN(Cc2ccccc2)c2ccccc21.O=C(O)C(F)(F)F>>CN[C@@H](C)C(=O)N[C@H]1CN(Cc2ccccc2)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20110288116A1,CC(=O)OC1CCN(C(=O)C(NC(=O)C(C)N(C)C(=O)OC(C)(C)C)C(C)(C)C)C1Cc1c[nH]c2ncccc12>>CNC(C)C(=O)NC(C(=O)N1CCC(OC(C)=O)C1Cc1c[nH]c2ncccc12)C(C)(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110269737A1,COc1c(NC(=O)c2cc3cccc(CN4CCN(C(=O)C5CCCN5C)CC4)c3n2C)cc(C(C)(C)C)cc1C(=O)O.NC1CC1>>COc1c(NC(=O)c2cc3cccc(CN4CCN(C(=O)[C@@H]5CCCN5C)CC4)c3n2C)cc(C(C)(C)C)cc1C(=O)NC1CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20130289031A1,CC1(C)CCNC(N)=N1.CCOC(=O)CC(=O)[O-]>>CC1(C)CCn2c(nc(O)cc2=O)N1,,CO,,[Na],,val
US20150152108A1,Cc1cc(-c2ccc3c(n2)N[C@H]2CCN3C2)ccn1.Nc1cc2cn[nH]c2cn1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cc(-c2ccc3c(n2)N(C(=O)Nc2cc4cn[nH]c4cn2)[C@H]2CCN3C2)ccn1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20030109556A1,CC(=O)NC(Cc1ccc(O)cc1)C(=O)NC(Cc1ccc(F)cc1)C(=O)N1CC(Cc2ccc3ccccc3c2)NC(=O)C1Cc1cn(Cc2ccccc2)cn1>>CC(=O)NC(Cc1ccc(O)cc1)C(=O)NC(Cc1ccc(F)cc1)C(=O)N1CC(Cc2ccc3ccccc3c2)NC(=O)C1Cc1c[nH]cn1,[Pd],CC(=O)O,CCO,C1=CCCCC1,,val
US20080262042A1,CN(Cc1cn(S(=O)(=O)c2cccc(C(=O)O)c2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C>>CN(Cc1cn(S(=O)(=O)c2cccc(CO)c2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C,,C1CCOC1,O,Cc1ccccc1,,val
US06602872B1,COC(=O)CBr.CSc1nccc(CC(=O)c2cccc(C(F)(F)F)c2)n1>>COC(=O)CC(C(=O)c1cccc(C(F)(F)F)c1)c1ccnc(SC)n1,,CS(C)=O,O,[H-].[Na+],,val
US20110182812A1,CCO/C=C/C(=O)C(Cl)(Cl)Cl.Nc1nc2ccccc2[nH]1>>ClC(Cl)(Cl)c1ccn2c(n1)nc1ccccc12,,Cc1ccccc1,,CCN(CC)CC,,val
US04298602,CCOC(OCC)OCC.NC(=O)NNc1ccccn1>>Oc1ncn(-c2ccccn2)n1,,CCO,,,,val
US04145364,Cc1cc(C)cc(N=[N+]=[N-])c1.F>>Cc1cc(N)cc(C)c1F,,CCCCCC,,,,val
US20110212103A1,COC(=O)c1sc2ncnc(Nc3cccnc3OC(C)CCNC(=O)OC(C)(C)C)c2c1C>>Cc1c(C(=O)O)sc2ncnc(Nc3cccnc3OC(C)CCNC(=O)OC(C)(C)C)c12,,CO,,Cl,[Na+].[OH-],val
US20120264749A1,CC(C)I.COC(=O)c1ccc(O)cc1F>>COC(=O)c1ccc(OC(C)C)cc1F,,CCOCC,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20060074237A1,CC(C)(C)C(=O)Nc1cccc(CO)n1.O=S(Cl)Cl>>CC(C)(C)C(=O)Nc1cccc(CCl)n1,,ClCCl,,,,val
US20090203676A1,CC(C)(C)OC(=O)N1CCC(C(=O)CBr)CC1.CS(=O)(=O)c1ccc(N2CCNCC2)cc1>>CC(C)(C)OC(=O)N1CCC(C(=O)CN2CCN(c3ccc(S(C)(=O)=O)cc3)CC2)CC1,,CC#N,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20120165304A1,CCOC(=O)C1CCN(C(=O)OC(C)(C)C)CCC1=O.Nc1cc[nH]n1>>CC(C)(C)OC(=O)N1CCc2nc3ccnn3c(O)c2CC1,,CC(=O)O,,,,val
US20050137201A1,Brc1cnc2[nH]ccc2c1.O.O=C(Cl)C(Cl)(Cl)Cl>>O=C(O)c1c[nH]c2ncc(Br)cc12,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20140045689A1,CCN1C(=O)C(Cl)=C(Cl)C1=O.CNC>>CN(C)C1=C(Cl)C(=O)N(C)C1=O,,C1CCOC1,,,,val
US20080038242A1,BrCc1ccccc1.N#Cc1ccc(C=O)c(O)c1>>N#Cc1ccc(C=O)c(OCc2ccccc2)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20050282808A1,CC(C)(C)OC(=O)CBr.CN(C)[C@@H]1CC[C@@H](C(=O)Nc2c(C(=O)Nc3ccc(Cl)cn3)oc3cc(O)ccc23)CC1>>CN(C)[C@@H]1CC[C@@H](C(=O)Nc2c(C(=O)Nc3ccc(Cl)cn3)oc3cc(OCC(=O)OC(C)(C)C)ccc23)CC1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070129416A1,CCOc1cc(Cl)c(S(C)(=O)=O)cc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1.O=C(Cl)Cl>>CCOc1cc(Cl)c(S(C)(=O)=O)cc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1C(=O)Cl,,CCN(CC)CC,,,,val
US20100234354A1,CN1CCC(COc2cnc(-c3cccc(CO)c3)nc2)CC1.N#Cc1cccc(-c2ccc(=O)[nH]n2)c1>>CN1CCC(COc2cnc(-c3cccc(Cn4nc(-c5cccc(C#N)c5)ccc4=O)c3)nc2)CC1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030092740A1,COC(=O)Nc1cc(C(=O)OC)n(-c2ccc(OC)cc2)n1>>COC(=O)Nc1ccn(-c2ccc(OC)cc2)n1,,Cc1ccccc1,ClCCl,C[Al](C)C,,val
US07709505B2,CC(C)CI.COC(=O)c1cc(O)c2cc(C)oc2c1>>COC(=O)c1cc(OCC(C)C)c2cc(C)oc2c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05179125,C1CCNC1.O=C(O)c1ccc(CBr)c([N+](=O)[O-])c1>>Nc1cc(C(=O)O)ccc1CN1CCCC1,,ClCCl,,,,val
US20120316368A1,O=C([O-])CCC(=O)[O-].[Mg+2]>>O=C([O-])CCC(=O)[O-].[Mg+2],,O,,,,val
US20070185140A1,Clc1nc(-n2cnc3ccccc32)c2nc[nH]c2n1.Nc1ccccc1>>c1ccc(Nc2nc(-n3cnc4ccccc43)c3nc[nH]c3n2)cc1,,ClCCl,,,,val
US06323235B1,BrCCOC1CCCCO1.c1ccc(COc2cccc3[nH]ccc23)cc1>>c1ccc(COc2cccc3c2ccn3CCOC2CCCCO2)cc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20120157435A1,CCc1cccc2c1Nc1ccccc1S2.II>>CCc1cccc2[s+]c3ccccc3nc12.[I-],,ClC(Cl)Cl,,,,val
US20070161615A1,CN(C)C(=O)[C@@H]1CCCN1c1ccc(NC(=N)N)cc1.Cc1ncc(C(=O)/C(F)=C/N(C)C)n1C(C)C>>Cc1ncc(-c2nc(Nc3ccc(N4CCC[C@H]4C(=O)N(C)C)cc3)ncc2F)n1C(C)C,,CCCCO,,,,val
US20150353573A1,COc1cc([C@@H]2c3cc4c(cc3[C@@H](NCC(F)(F)[C@@H]3O[C@H](COCc5ccccc5)[C@@H](OCc5ccccc5)[C@H](OCc5ccccc5)[C@H]3OCc3ccccc3)[C@H]3COC(=O)[C@@H]32)OCO4)cc(OC)c1OC>>COc1cc([C@@H]2c3cc4c(cc3[C@@H](NCC(F)(F)[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H]3COC(=O)[C@@H]32)OCO4)cc(OC)c1OC,[Pd],C1CCOC1,CO,,,val
US20030229058A1,COc1ccc([N+](=O)[O-])cc1-c1ccc(CN)cc1>>COc1ccc(N)cc1-c1ccc(CN)cc1,[Pd],CO,,[H][H],,val
US20050272036A1,Fc1ccccc1CCl.O=C(Cn1cncn1)c1cccs1>>O=C(c1cccs1)C(Cc1ccccc1F)n1cncn1,,CN(C)C=O,,[H-].[Na+],,val
US20110288111A1,O=C1CC2(CCCCC2)CC(=O)N1>>C1CCC2(CC1)CCNCC2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070249688A1,CCCC(=O)c1ccc(C(=O)OC)cc1>>CCCC(O)c1ccc(C(=O)OC)cc1,,C1CCOC1,CCO,[BH4-].[Na+],,val
US20080045493A1,CC(c1ccc(S(=O)(=O)Cl)cc1)C(F)F.CCCN1CC(c2ccc(N)cc2)C1>>CCCN1CC(c2ccc(NS(=O)(=O)c3ccc(C(C)C(F)F)cc3)cc2)C1,,ClCCl,c1ccncc1,,,val
US20070032494A1,CC(C)c1cc(Cc2c(Cl)cc(N3C(=O)c4ccccc4C3=O)cc2Cl)nn(C)c1=O>>CC(C)c1cc(Cc2c(Cl)cc(N)cc2Cl)nn(C)c1=O,,CC(=O)O,,,,val
US20130225561A1,COC(=O)Cc1cc(F)c(C#N)cc1F>>N#Cc1cc(F)c(CCO)cc1F,,C1CCOC1,,O,[BH4-].[Li+],val
US04720500,Nc1ccc2ccc(Cl)nc2n1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1ccc2ccc(Cl)nc2n1,,C1CCOC1,,,,val
US06610692B1,CCOC(=O)Cn1c(Cl)cnc(N[C@@H]2COC[C@H]2OCC2CC2)c1=O>>O=C(O)Cn1c(Cl)cnc(N[C@@H]2COC[C@H]2OCC2CC2)c1=O,,CCO,,Cl,[Na+].[OH-],val
US06384080B1,COc1ccc(CNC(=O)c2cc(C#N)ccc2N[C@@H]2CCNC2)cc1OC.O=C=NS(=O)(=O)Cl.OCc1ccccc1>>COc1ccc(CNC(=O)c2cc(C#N)ccc2N[C@@H]2CCN(S(=O)(=O)NC(=O)OCc3ccccc3)C2)cc1OC,,ClCCCl,,CCN(CC)CC,,val
US20040034046A1,C=O.COc1cc2c(Nc3cccc4c3OCO4)ncnc2cc1OCCC1(O)CCNCC1>>COc1cc2c(Nc3cccc4c3OCO4)ncnc2cc1OCCC1(O)CCN(C)CC1,,O=CO,,[Na+].[OH-],,val
US20040034005A1,Clc1ccc2c3c(n4c2c1CCNCC4)CCCCC3>>Clc1ccc2c3c1CCNCCN3C1CCCCCC21,,CC(=O)O,,[BH3-]C#N.[Na+],,val
US20030092720A1,COc1ccc(Cn2nnc(-c3cnc4cc(C(=O)Nc5nc(C(C)C)cs5)ccn4c3=O)n2)cc1>>CC(C)c1csc(NC(=O)c2ccn3c(=O)c(-c4nn[nH]n4)cnc3c2)n1,,O=C(O)C(F)(F)F,,,,val
US20110275611A1,COc1ccc2[nH]c(C3CN(Cc4ccccc4)CCO3)nc2c1>>COc1ccc2[nH]c(C3CNCCO3)nc2c1,[Pd],CO,,Cl,ClCCl,val
US20150152216A1,Brc1cccnc1.O=Cc1ccccc1Br>>OC(c1cccnc1)c1ccccc1Br,,CCOCC,,[Li]CCCC,,val
US20060199828A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1nccnc1N>>COC(=O)c1nccnc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,,,val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Nc1ccc(C(F)(F)F)c(F)c1>>COc1ccc2nc(Nc3ccc(C(F)(F)F)c(F)c3)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US04474754,CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NNC(=O)OC(C)(C)C>>CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NN,,O=C(O)C(F)(F)F,,CCOCC,,val
US06403791B1,CCc1nc2c(OC(F)F)ccc(C(=O)O)c2o1.CCc1noc(C)c1N>>CCc1nc2c(OC(F)F)ccc(C(=O)Nc3c(CC)noc3C)c2o1,,CCCCCC,CCOCC,,,val
US20050234081A1,CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cncc(Br)c1.Cc1cccc(COC(B2OC(C)(C)C(C)(C)O2)C(=O)OC(C)(C)C)c1>>CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cncc(-c2c(C)cccc2COCC(=O)OC(C)(C)C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,Cc1ccccc1,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20110257230A1,COC(=O)c1ccc(Nc2ccnc(Br)c2)c([N+](=O)[O-])c1>>COC(=O)c1ccc(Nc2ccnc(Br)c2)c(N)c1,[Ni],CO,,,,val
US20080319005A1,CCOC(=O)Cc1ccc(N)cc1Cl.O=[N+]([O-])c1cccnc1Cl>>CCOC(=O)Cc1ccc(Nc2ncccc2[N+](=O)[O-])cc1Cl,,C1COCCO1,CCO,,,val
US06391520B1,C=CC(=O)Cl.OC12CC3CC(O)(C1)CC(O)(C3)C2>>C=CC(=O)OC12CC3CC(O)(CC(O)(C3)C1)C2,,O,,C1CCOC1,CCN(CC)CC,val
US04935431,COC(=O)c1cscc1OC(C)=O>>COC(=O)c1cscc1OC,,CO,,O=S(=O)(O)O,,val
US20130245049A1,CCOC(=O)CC(=O)OCC.Cc1ccc(C(=O)c2cc3ccccc3nc2N)cc1>>CCOC(=O)c1c(O)nc2nc3ccccc3cc2c1-c1ccc(C)cc1,,CCO,,C,C[O-].[Na+],val
US20160016935A1,C[C@@H]1CC[C@@H](O)CN1C(=O)c1ccsc1-c1ncccn1.Fc1cc(Br)ccn1>>C[C@@H]1CC[C@@H](Oc2cc(Br)ccn2)CN1C(=O)c1ccsc1-c1ncccn1,,C1CCOC1,,[H-].[Na+],,val
US20080292548A1,CO.N#Cc1ccc(F)cc1C(=O)O>>COC(=O)c1cc(F)ccc1C#N,,CO,,CC(=O)Cl,,val
US04389416,CCOC(=O)CBr.O=[N+]([O-])c1ccc(Oc2ccc(O)c(Cl)c2Cl)cc1>>CCOC(=O)COc1ccc(Oc2ccc([N+](=O)[O-])cc2)c(Cl)c1Cl,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04482556,CCC(C)N.COc1cc2c(cc1OC)-c1cc(Cl)nc(=O)n1CC2>>CCC(C)Nc1cc2n(c(=O)n1)CCc1cc(OC)c(OC)cc1-2.Cl,,CN(C)C=O,,,,val
US20090137595A1,Nc1cc(O)ccc1Cl.O=C(Nc1cn2nc(I)ccc2n1)C1CC1>>Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)ccc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160002255A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.COc1ccc(F)c(-c2ccc([C@H](O)CO)c(C(F)(F)F)n2)c1>>COc1ccc(F)c(-c2ccc([C@H](O)CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)c(C(F)(F)F)n2)c1,,ClCCl,,c1c[nH]cn1,,val
US05451678,CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)N=[N+]=[N-]>>CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@@H](N)Cc1ccccc1,[Pd],CCO,,,,val
US06166006,CI.Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN4CCCCC4)cc2)CC3)cc1>>Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(C[N+]4(C)CCCCC4)cc2)CC3)cc1.[I-],,CN(C)C=O,,,,val
US20090324581A1,CC(C)(C)OC(=O)CCN(CC(=O)N1CCOc2cc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)ccc21)C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C(O)CCNCC(=O)N1CCOc2cc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)ccc21,,ClCCl,,,,val
US20120188317A1,CC#N.Nc1cc(S(=O)(=O)O)ccc1S(=O)(=O)O>>N#Cc1ccccc1C#N,,O,,,,val
US05891871,COC(=O)Cc1ccc2c(c1)OCO2.O=C(Cl)c1ccco1>>COC(=O)Cc1cc2c(cc1C(=O)c1ccco1)OCO2,,ClCCl,,Cl[Sn](Cl)(Cl)Cl,,val
US20070244104A1,CC(=O)Nc1nc2c(s1)-c1nc(-c3cc(C#CC4CCNCC4)ccc3Cl)ncc1CC2.CC(=O)O>>CC(=O)Nc1nc2c(s1)-c1nc(-c3cc(C#CC4CCN(C(C)=O)CC4)ccc3Cl)ncc1CC2,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20150284370A1,CC1(C)OB(c2ccc(C(=O)NCCO)cc2)OC1(C)C.CCN(c1cc(Br)cc(C(=O)NCc2c(C(C)C)cc(C)[nH]c2=O)c1C)C1CCOCC1>>CCN(c1cc(-c2ccc(C(=O)NCCO)cc2)cc(C(=O)NCc2c(C(C)C)cc(C)[nH]c2=O)c1C)C1CCOCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20050148604A1,COC(=O)C(F)(F)Cl.COC(=O)c1ccc(Br)cc1O>>COC(=O)c1ccc(Br)cc1OC(F)F,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130143843A1,O=Cc1ccc(O)cc1.OCCCC(F)(F)F>>O=Cc1ccc(OCCCC(F)(F)F)cc1,,ClCCl,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090062529A1,COc1cc(/C=C/c2nc3n(n2)CCCC3C2CCNCC2)ccc1-n1cnc(C)c1.O=C(Cl)c1ccccc1>>COc1cc(/C=C/c2nc3n(n2)CCCC3C2CCN(C3(C=O)C=CC=CC3)CC2)ccc1-n1cnc(C)c1,,ClCCl,,[Na+].[OH-],,val
US20070299066A1,OCCn1cc2c(n1)CCc1c-2sc2ncnc(Nc3ccc(F)c(Cl)c3)c12>>OCCn1cc2c(ccc3c2sc2ncnc(Nc4ccc(F)c(Cl)c4)c23)n1,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20160102059A1,CCOP(C)(=O)c1ccc([N+](=O)[O-])cc1F.CNC>>CCOP(C)(=O)c1ccc([N+](=O)[O-])cc1N(C)C,,CN(C)C=O,CO,CCN(CC)CC,Cl,val
US20100075953A1,ClCCCBr.O=C(c1cccc2ccccc12)N1CCN(CCc2ccc(O)cc2)CC1>>O=C(c1cccc2ccccc12)N1CCN(CCc2ccc(OCCCCl)cc2)CC1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130158075A1,COC(=O)CCC(=O)NCC(=O)c1ccc([N+](=O)[O-])cc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COC(=O)CCc1ncc(-c2ccc([N+](=O)[O-])cc2)s1,,C1COCCO1,CCOC(C)=O,O,O=C([O-])[O-].[Na+].[Na+],val
US20130131051A1,CC1=C(CO)CCCc2ccc(NC(=O)c3ccc(Cl)cn3)cc21.CS(=O)(=O)Cl>>CC1=C(CCl)CCCc2ccc(NC(=O)c3ccc(Cl)cn3)cc21,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130224186A1,OCc1nc(-c2cc(F)ccc2F)oc1Cc1ccccc1>>O=Cc1nc(-c2cc(F)ccc2F)oc1Cc1ccccc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20050176964A1,Cc1ccc(C(=O)O)cc1B1OC(C)(C)C(C)(C)O1.NCC1CC1>>Cc1ccc(C(=O)NCC2CC2)cc1B1OC(C)(C)C(C)(C)O1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06130187,CCS.Cn1c(C(F)(F)F)cc(=O)n(-c2c(F)cc(Cl)c3cc(CBr)oc23)c1=O>>CCSCc1cc2c(Cl)cc(F)c(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c2o1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150148313A1,CCOC(=O)C(CC)(C(=O)OCC)c1ccc([N+](=O)[O-])cc1CN(C)C(=O)OCc1ccccc1>>CCC(C(=O)O)c1ccc([N+](=O)[O-])cc1CN(C)C(=O)OCc1ccccc1,,CCO,,[Na+].[OH-],,val
US03950383,C=CC#N.CNCC(=O)Nc1ccc(Cl)cc1C(=O)c1ccccc1.Cl>>CN(CCC#N)CC(=O)Nc1ccc(Cl)cc1C(=O)c1ccccc1.Cl,,CCOCC,,,,val
US20160031857A1,COC(=O)Cc1ccc2c(c1)CCN2c1nc(-c2ccc(Cl)s2)nc2c1CCC2>>O=C(O)Cc1ccc2c(c1)CCN2c1nc(-c2ccc(Cl)s2)nc2c1CCC2,,CO,,Cl,[Na+].[OH-],val
US20080306083A1,CC(C)(C)OC(=O)n1ccc(CBr)n1.C[C@H]1CNC[C@@H](C)N1>>C[C@H]1CN(Cc2ccn(C(=O)OC(C)(C)C)n2)C[C@@H](C)N1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US08232273B2,CC(C)(C)OC(=O)c1nc(N2CCc3cccc(C(=O)N(COCC[Si](C)(C)C)c4nc5ccccc5s4)c3C2)sc1C#CCO>>CC(C)(C)OC(=O)c1nc(N2CCc3cccc(C(=O)N(COCC[Si](C)(C)C)c4nc5ccccc5s4)c3C2)sc1CCCO,O=[Pt]=O,CCOC(C)=O,,,,val
US20150133457A1,COCCN1CC[C@H](N(c2ccc([N+](=O)[O-])cc2)C2CC2)C1>>COCCN1CC[C@H](N(c2ccc(N)cc2)C2CC2)C1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20120071514A1,Br[Mg]C1CC1.Cn1c(=O)oc2ccc(-c3cnccc3C=O)cc21>>Cn1c(=O)oc2ccc(-c3cnccc3C(O)C3CC3)cc21,,C1CCOC1,,,,val
US20100010053A1,C=CC(=O)OCC.N#Cc1ccc2cc[nH]c2c1>>CCOC(=O)CCc1c[nH]c2cc(C#N)ccc12,,ClCCCl,ClCCl,,,val
US20050054637A1,NC(=O)[C@@H](NC(=O)[C@@H]1CCCC[C@H]1N1CCNCC1)c1ccccc1.O=C=NCc1ccc(F)cc1>>NC(=O)[C@@H](NC(=O)[C@@H]1CCCC[C@H]1N1CCN(C(=O)Nc2ccc(F)cc2)CC1)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20100056530A1,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.Cc1csc(Nc2ncc(C=O)cc2OCc2ccccc2)n1>>COC(=O)/C=C/c1cnc(Nc2nc(C)cs2)c(OCc2ccccc2)c1,,C1CCOC1,,,,val
US05180735,Br.CO[C@@H]1[C@H](O)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C>>COC1C(O)CCC(O)(CBr)C1C1(C)OC1CC=C(C)C,,CCO,,O=C([O-])O.[Na+],,val
US20100137417A1,COC(=O)CCNC(=O)c1ccc(C(Oc2cc(C)c(-c3ccc(OC(F)(F)F)cc3)c(C)c2)C(C)C)s1>>Cc1cc(OC(c2ccc(C(=O)NCCC(=O)O)s2)C(C)C)cc(C)c1-c1ccc(OC(F)(F)F)cc1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20100035944A1,COC(=O)COc1ccc(OCc2nc(-c3ccccc3Cl)cs2)cc1C>>Cc1cc(OCc2nc(-c3ccccc3Cl)cs2)ccc1OCC(=O)O,,O,,Cl,[Li+].[OH-],val
US20130296354A1,CC(C)(C)OC(=O)N1CCC2(CC1)CC1(Cc3cc(C4=CCN(S(C)(=O)=O)CC4)ncc3O1)C2>>CC(C)(C)OC(=O)N1CCC2(CC1)CC1(Cc3cc(C4CCN(S(C)(=O)=O)CC4)ncc3O1)C2,[Pd],CO,,,,val
US04043956,C=CC(=O)OCCCC.O=C1C=CC(=O)O1>>C=CC(=O)OCCCC.O=C1C=CC(=O)O1,,Cc1ccccc1,,,,val
US20140275528A1,CCCOCCC(=O)O.Cn1c(N)c(N)c(=O)n(C)c1=O>>CCCOCCC(=O)Nc1c(N)n(C)c(=O)n(C)c1=O,,CCO,,CCN=C=NCCCN(C)C,,val
US20100297035A1,CCOC(=O)c1[nH]c(-c2cccc3ccccc23)nc1C>>Cc1nc(-c2cccc3ccccc23)[nH]c1CO,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20090270374A1,C=CCn1c(=O)ccc2ncc(OC)cc21.O=[Os](=O)(=O)=O>>COc1cnc2ccc(=O)n(CC=O)c2c1,O=[Os](=O)(=O)=O,C1COCCO1,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20050101591A1,O=C1c2c(-c3ccccc3)cc[n+]([O-])c2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=P(Cl)(Cl)Cl>>O=C1c2c(-c3ccccc3)cc(Cl)nc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CCOC(C)=O,,,,val
US20050245521A1,CN1CCN(c2ccccc2C=C2CCNC2=O)CC1>>CN1CCN(c2ccccc2CC2CCNC2=O)CC1,[Pd],CCO,,O=C[O-].[NH4+],,val
US05254543,CCCCc1cc(C(=O)O)cc(=O)[nH]1>>CCCCc1cccc(=O)[nH]1,O=[Cu-],c1ccc2ncccc2c1,,,,val
US03956260,CC(C)(C)OC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(N)=O.NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1>>CC(C)(C)OC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1,,CN(C)C=O,,,,val
US20160152624A1,COC(=O)c1ccc(-n2ccc3c(C)nc(-c4ccc(OC)c(F)c4)nc32)cc1>>COc1ccc(-c2nc(C)c3ccn(-c4ccc(C(=O)O)cc4)c3n2)cc1F,,C1COCCO1,CO,Cl,[Na+].[OH-],val
US20040133008A1,NCCn1nccc1NC(c1ccccc1)(c1ccccc1)c1ccccc1.O=[N+]([O-])c1ccc(Cl)nc1>>O=[N+]([O-])c1ccc(NCCn2nccc2NC(c2ccccc2)(c2ccccc2)c2ccccc2)nc1,,CN(C)C=O,,CCN(CC)CC,O,val
US20130190268A1,C=CCI.COc1ccc(CN2C(=O)N(Cc3ccc(OC)cc3)[C@@H]3[C@H](CCCCCO)SC[C@@H]32)cc1>>C=CCOCCCCC[C@@H]1SC[C@H]2[C@@H]1N(Cc1ccc(OC)cc1)C(=O)N2Cc1ccc(OC)cc1,,CO,,[H-].[Na+],,val
US20140256736A1,COc1ccc(CN(c2ncccn2)S(=O)(=O)c2ccc(F)c(F)c2)c(OC)c1.O=c1[nH]c2cc(-c3cc(Cl)ccc3O)ccc2o1>>COc1ccc(CN(c2ncccn2)S(=O)(=O)c2ccc(Oc3ccc(Cl)cc3-c3ccc4oc(=O)[nH]c4c3)c(F)c2)c(OC)c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100144745A1,COC[C@H]1CCC[C@H](N2C(=O)c3ccccc3C2=O)C1>>COC[C@H]1CCC[C@H](N)C1,,CCO,,NN,,val
US20090023932A1,CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.Cl.Cl>>CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1.Cl.Cl,,CC(C)=O,,,,val
US20040019051A1,CCOC(=O)C1=Cc2ncccc2OC1>>OCC1=Cc2ncccc2OC1,,C1CCOC1,CO,[BH4-].[Na+],[Cl-].[NH4+],val
US20040242874A1,O=C(O)[C@@H]1CCCN1.O=N[O-]>>O=NN1CCC[C@H]1C(=O)O,,O,,Cl,,val
US20100125091A1,CC(=O)CC(=O)N1CCCCC1.Nc1ccc(Cl)cc1CC(=O)c1ccccc1>>Cc1nc2ccc(Cl)cc2c(-c2ccccc2)c1C(=O)N1CCCCC1,,CCO,,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US20150366990A1,CC(C)[C@H](NC(=O)CCCCCN1C(=O)C=CC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1.O=C(Oc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1>>CC(C)[C@H](NC(=O)CCCCCN1C(=O)C=CC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)Oc2ccc([N+](=O)[O-])cc2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20030171377A1,COC(=O)[C@H](Cc1ccc(OC(C)=O)cc1)n1c(C)ccc1C.NC(=O)CCC(=O)NCl>>COC(=O)[C@H](Cc1ccc(OC(C)=O)cc1)n1c(C)cc(Cl)c1C,,C1CCOC1,,,,val
US20050107364A1,COC1=CC(=O)c2ccccc2C1(C)CCC1CC1>>CC1(CCC2CC2)C(=O)C=C(O)c2ccccc21,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20100029621A1,CC(C)(C)OC(=O)N1CCCNCC1.OC(c1ccc(CBr)cc1)(C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCCN(Cc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)CC1,,CC#N,,O=C([O-])O.[Na+],,val
US20100286136A1,Cc1cc(N)ccc1Cl.O=C(Cl)C=Cc1ccccc1>>Cc1cc(NC(=O)C=Cc2ccccc2)ccc1Cl,,ClCCl,c1ccncc1,,,val
US20150158808A1,CCOC=C(C(=O)OCC)C(=O)C(F)F.CNN>>CCOC(=O)c1cn(C)nc1C(F)F,,Cc1ccccc1,O,O=C([O-])[O-].[K+].[K+],,val
US20140045862A1,COc1ccc(CNc2ccncn2)c(OC)c1.O=S(=O)(Cl)c1ccc(F)c(Cl)c1>>COc1ccc(CN(c2ccncn2)S(=O)(=O)c2ccc(F)c(Cl)c2)c(OC)c1,,CC#N,,C1CN2CCN1CC2,,val
US20060052374A1,Fc1ccccn1.Oc1cc(F)c(F)cc1Br>>Fc1cc(Br)c(Oc2ccccn2)cc1F,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20130210664A1,CC1(C)O[C@@H]2[C@H](O1)[C@@H](CSCC[C@H](N)C(=O)O)O[C@H]2n1cnc2c(N)nc(NCCCN)nc21>>NCCCNc1nc(N)c2ncn([C@@H]3O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]3O)c2n1,,O=C(O)C(F)(F)F,,O,,val
US20050026989A1,COC(=O)c1c[nH]c2cc(OC)ccc12.Clc1ccnc2ccccc12>>COC(=O)c1cn(-c2ccnc3ccccc23)c2cc(OC)ccc12,,CN(C)C=O,,O,[H-].[Na+],val
US20070105904A1,O=[N+]([O-])/C=C/c1ccc(OC2CCCCC2)cc1>>O=[N+]([O-])CCc1ccc(OC2CCCCC2)cc1,,CS(C)=O,,CC(=O)O,[BH4-].[Na+],val
US20100249119A1,CC(C)(C#N)c1cccc(C(=O)O)c1Cl.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)sc3n2)c(Cl)cc1F>>CC(C)(C#N)c1cccc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)sc4n3)c(Cl)cc2F)c1Cl,,C1CCOC1,CN(C)C=O,O=C(Cl)C(=O)Cl,O=C([O-])O.[Na+],val
US08623880B2,Cc1c2c(=O)n(C)c(=O)n(C)c2nn1C.O=C(CBr)Nc1nc(-c2ccc(C(F)(F)F)c(F)c2)cs1>>Cc1cc2c(c(=O)n(C)c(=O)n2C)n1CC(=O)Nc1nc(-c2ccc(C(F)(F)F)c(F)c2)cs1,,CN(C)C=O,,[H-].[Na+],,val
US20120053166A1,COc1ncc(-c2cc(-c3nnc(CN4C[C@H](C)O[C@H](C)C4)o3)c3cnn(S(=O)(=O)c4ccccc4)c3c2)cc1N.O=S(=O)(Cl)c1ccc(F)cc1F>>COc1ncc(-c2cc(-c3nnc(CN4C[C@H](C)O[C@H](C)C4)o3)c3cnn(S(=O)(=O)c4ccccc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F,,c1ccncc1,,O,,val
US20050234244A1,COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccccc1>>Cc1c(CC(=O)O)c2cc(O)ccc2n1C(=O)c1ccccc1,,ClCCl,,BrB(Br)Br,,val
US20100331315A1,C[C@H](Nc1cncc(-c2cccc(C=O)c2)n1)c1ccccc1.O=C1CSC(=O)N1>>C[C@H](Nc1cncc(-c2cccc(C=C3SC(=O)NC3=O)c2)n1)c1ccccc1,,CCO,,C1CCNCC1,,val
US04600709,CCOC(=O)C(Cl)Cl.Cc1cc(O)c(O)cc1S(=O)(=O)c1cccs1>>Cc1cc2c(cc1S(=O)(=O)c1cccs1)OC(C(=O)O)O2,,COCCOC,O,Cl,O=C([O-])[O-].[K+].[K+],val
US05691348,CCCCc1nc2nc(CO)c(Br)cc2[nH]1>>CCCCc1nc2nc(C=O)c(Br)cc2[nH]1,O=[Mn]=O,ClCCl,,,,val
US05684034,CCOC(=O)CBr.Cc1c(CC(=O)O)c2cc(O)ccc2n1Cc1ccccc1>>CCOC(=O)COc1ccc2c(c1)c(CC(=O)O)c(C)n2Cc1ccccc1,,C1CCOC1,CS(C)=O,Cl,[H-].[Na+],val
US20040157886A1,O=[N+]([O-])c1ccc2c(c1)OCC(=S)N2>>Nc1ccc2c(c1)OCC(=S)N2,,CCO,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20090209532A1,CCOC(=O)c1cc2cc(OC)c(O)cc2o1.O=[N+]([O-])O>>CCOC(=O)c1cc2cc(OC)c(O)c([N+](=O)[O-])c2o1,,ClCCl,,,,val
US20080312183A1,CC(C)=O.OCCC(CO)CO>>CC1(C)OCC(CCO)CO1,,CC(C)=O,,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US20150297587A1,CC1CNCCN1C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)n2cc(-c3ccc4[nH]ccc4c3)c3cc(-c4ccc(C=O)cc4)cnc32)cc1>>Cc1ccc(S(=O)(=O)n2cc(-c3ccc4[nH]ccc4c3)c3cc(-c4ccc(CN5CCN(C(=O)OC(C)(C)C)C(C)C5)cc4)cnc32)cc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100204119A1,C[C@@H]1CN(c2ccc(C3(C(=O)O)CCCCC3)cc2)C(=O)c2c(N)ncnc2O1.N>>C[C@@H]1CN(c2ccc(C3(C(N)=O)CCCCC3)cc2)C(=O)c2c(N)ncnc2O1,,CN(C)C=O,,,,val
US04599344,CC(C)(C)OC(=O)CC1CO1.Cl.Clc1ccc(CC=C2CN3CCC2CC3)cc1>>CC(C)(C)OC(=O)CC(O)C[N+]12CCC(CC1)C(=CCc1ccc(Cl)cc1)C2.[Cl-],,CO,,,,val
US05756769,CS(=O)(=O)OCC#Cc1cccs1.N.O=Cc1ccccc1>>C(#Cc1cccs1)CN=Cc1ccccc1,,Cc1ccccc1,,,,val
US20060116366A1,CC(C)(C)C1CCC(C(=O)O)CC1.ClCCl>>COC(=O)C1CCC(C(C)(C)C)CC1,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20080177095A1,CCCC1CCc2c(c(F)c(F)c3oc(C)cc23)O1>>CCCC1CCc2c3c(c(F)c(F)c2O1)OC(C)C3,[Pd],C1CCOC1,,,,val
US20090105072A1,CN(C)C=C1CCCCCC1=O.Cc1ccc(C(=N)N)nc1Br>>Cc1ccc(-c2ncc3c(n2)CCCCC3)nc1Br,,CO,,Cl,C[O-].[Na+],val
US20070003539A1,CC(C)Sc1ccc([N+](=O)[O-])cc1C=O.Cc1ccc([S@@](N)=O)cc1>>Cc1ccc([S@](=O)/N=C/c2cc([N+](=O)[O-])ccc2SC(C)C)cc1,,ClCCl,,,,val
US20080045514A1,Cc1cc(Cl)ccc1-c1nnc(S)n1N.Cc1ccc(C(=O)CBr)cc1>>Cc1ccc(C2=Nn3c(nnc3-c3ccc(Cl)cc3C)SC2)cc1,,CC(C)O,,,,val
US20150291563A1,CC(C)(C)OC(=O)NC1CCN(c2ccc(C3CC(C(O)(C(F)(F)F)C(F)(F)F)=NN3c3ccccc3Cl)cc2)CC1.Cl>>Cl.NC1CCN(c2ccc(C3CC(C(O)(C(F)(F)F)C(F)(F)F)=NN3c3ccccc3Cl)cc2)CC1,,CCOC(C)=O,,,,val
US07238714B2,COC(=O)c1ccc([C@H](C)NC(=O)c2cc(C#N)ccc2Oc2cccc(F)c2)cc1>>C[C@H](NC(=O)c1cc(C#N)ccc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1,,ClCCl,,BrB(Br)Br,O,val
US20040116471A1,COC(=O)c1cccc(CBr)c1.c1cncc(Cn2cc(C3CCNCC3)c3ccccc32)c1>>O=C(O)c1cccc(CN2CCC(c3cn(Cc4cccnc4)c4ccccc34)CC2)c1,,ClCCl,,CCN(CC)CC,,val
US04400316,COC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)OC(C)(C)C.NN>>CC(C)(C)OC(=O)N[C@@H](COCc1ccccc1)C(=O)N[C@@H](COCc1ccccc1)C(=O)NN,,CN(C)C=O,,O,,val
US20140228361A1,C#Cc1cc(Nc2ncnc3cc(OC)c(O)cc23)ccc1F.ClCCCBr>>C#Cc1cc(Nc2ncnc3cc(OC)c(OCCCCl)cc23)ccc1F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080114006A1,CCOC(=O)Cc1cc([N+](=O)[O-])c(F)cc1Cl>>CCOC(=O)Cc1cc(N)c(F)cc1Cl,[Ni],CCO,,,,val
US20090209540A1,COC(=O)c1cnc(-c2ccc(C)nc2)c(Cl)c1.O=[Se]=O>>COC(=O)c1cnc(-c2ccc(C=O)nc2)c(Cl)c1,,C1COCCO1,,,,val
US20110319381A1,CCOC(=O)c1cc(COC(=O)NC2CC3(CCN(c4ccc(Br)cn4)C3)C2)on1.OB(O)c1ccc(F)cc1>>CCOC(=O)c1cc(COC(=O)NC2CC3(CCN(c4ccc(-c5ccc(F)cc5)cn4)C3)C2)on1,,ClCCl,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100144760A1,Cc1cc(C)nc(Cl)n1.Cc1ccc(S(=O)(=O)N2C[C@@H]3C[C@@H]3C[C@H]2CN)cc1>>Cc1ccc(S(=O)(=O)N2C[C@@H]3C[C@@H]3C[C@H]2CNc2nc(C)cc(C)n2)cc1,,CS(C)=O,O,CCN(C(C)C)C(C)C,,val
US20100041636A1,C#Cc1cccc(O)c1.CN(C)CCCl>>C#Cc1cccc(OCCN(C)C)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05439909,O=C(C1=COc2cc(O)ccc2O1)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1.O=C(Cl)c1cccnc1>>O=C(Oc1ccc2c(c1)OC=C(C(=O)N1CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC1)O2)c1cccnc1,,CC(Cl)Cl,,c1ccncc1,,val
US20100016279A1,CC(C)(C)OC(=O)Nc1ccc(C=O)cc1.FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12>>CC(C)(C)OC(=O)Nc1ccc(CN2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1,,CC(=O)O,ClCCl,,,val
US20140315917A1,CC(C)(C)C1CO1.Cn1cc(-c2cc(Oc3cc(F)c(NC(=O)N4CCNC4=O)cc3Cl)ccn2)cn1>>Cn1cc(-c2cc(Oc3cc(F)c(NC(=O)N4CCN(CC(O)C(C)(C)C)C4=O)cc3Cl)ccn2)cn1,,CN(C)C=O,,O,[H-].[Na+],val
US05486603,CC(N)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C,,c1ccncc1,,,,val
US20060194783A1,BrCC1CC1.CC(C)(C)OC(=O)N[C@@H]1CCCCNC1=O>>CC(C)(C)OC(=O)N[C@@H]1CCCCN(CC2CC2)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US04968343,CC(Oc1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1)C(=O)Cl.Nc1ccc(C(F)(F)F)cc1>>CC(Oc1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1)C(=O)Nc1ccc(C(F)(F)F)cc1,,CC#N,,CCN(CC)CC,Cl,val
US20110152273A1,COC(=O)c1c(I)ccnc1Cl.N#C[Cu]>>COC(=O)c1c(C#N)ccnc1Cl,,CC(=O)N(C)C,,,,val
US20040087577A1,CCCCI.O=C(O)c1cccnc1O>>CCCCn1cccc(C(=O)O)c1=O,,Cl,O,CO,[K+].[OH-],val
US20110224204A1,O=[N+]([O-])c1cccc(OS(=O)(=O)C(F)(F)F)c1-c1ccc(OCc2ccccc2)cc1.OB(O)c1ccncc1>>O=[N+]([O-])c1cccc(-c2ccncc2)c1-c1ccc(OCc2ccccc2)cc1,,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US06271225B1,CCOC(=O)c1c(N)sc2cc(OC)ccc12.O=[N+]([O-])c1ccc(F)cc1F>>CCOC(=O)c1c(Nc2cc(F)ccc2[N+](=O)[O-])sc2cc(OC)ccc12,,CS(C)=O,,,,val
US04503049,CC(C)Cc1ccc(C(C)C(=O)O)cc1.ClP(Cl)(Cl)(Cl)Cl>>CC(C)Cc1ccc(C(C)C(=O)Cl)cc1,,CCOCC,,,,val
US20140066422A1,COc1ccc(O)cc1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>COc1ccc(Oc2nc(Cl)ncc2[N+](=O)[O-])cc1,,CC(C)=O,O,O=C([O-])O.[Na+],,val
US04371720,BrCCC1OCCO1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>[Br-].c1ccc([P+](CCC2OCCO2)(c2ccccc2)c2ccccc2)cc1,,Cc1ccccc1,,,,val
US20140038999A1,COC(=O)c1c(-c2ccc(Br)c(F)c2F)ccnc1C>>Cc1nccc(-c2ccc(Br)c(F)c2F)c1C(=O)O,,CO,O,Cl,[Na+].[OH-],val
US20130137675A1,Fc1cccc(C(F)(F)F)c1.Oc1ccncc1Cl>>O=c1ccn(-c2cccc(C(F)(F)F)c2)cc1Cl,,CN1CCCC1=O,O,O=C([O-])[O-].[K+].[K+],,val
US20020022631A1,CCOC(=O)C(Cc1cnccn1)NC(C)=O>>CC(=O)NC(CO)Cc1cnccn1,,CCO,O,[BH4-].[Na+],,val
US20140275026A1,COc1nccc2c(I)c[nH]c12.OB(O)c1ccccc1Oc1ccccc1>>COc1nccc2c(-c3ccccc3Oc3ccccc3)c[nH]c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,,[Cs+].[F-],,val
US06657062B1,CS(=O)(=O)OC[C@@H]1CN(Cc2ccccc2)CC[C@@H]1c1ccc(F)cc1.Oc1ccc2c(c1)OCO2>>Fc1ccc([C@@H]2CCN(Cc3ccccc3)C[C@H]2COc2ccc3c(c2)OCO3)cc1,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20130256646A1,Brc1cccc(-c2cncnc2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC1(C)OB(c2cccc(-c3cncnc3)c2)OC1(C)C,,C1COCCO1,,ClCCl,CC(=O)[O-].[K+],val
US05268386,CCOC(=O)CCCBr.O=C1CC2(CCCCC2)Oc2cc(O)cc(O)c21>>CCOC(=O)CCCOc1cc(O)c2c(c1)OC1(CCCCC1)CC2=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150252044A1,CS(=O)(=O)CCN.O=C(O)c1ccc2cncc(Br)c2n1>>CS(=O)(=O)CCNC(=O)c1ccc2cncc(Br)c2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090042872A1,NCCOc1ccc(C=O)c(OCc2ccccc2Br)c1.O=C(Cl)c1ccccc1>>O=Cc1ccc(OCCNC(=O)c2ccccc2)cc1OCc1ccccc1Br,,ClCCl,,CCN(CC)CC,,val
US20160075657A1,CC(=O)OC(C)=O.COc1cccc2c1CCN(Cc1ccc([C@H](C)N)cc1)C2>>COc1cccc2c1CCN(Cc1ccc([C@H](C)NC(C)=O)cc1)C2,,ClCCl,,CO,Cl,val
US20140080808A1,CSC1=NCCSC(C)(CO[Si](C)(C)C(C)(C)C)C1.NNC(=O)C1(c2ccc(Br)cc2F)CC1>>CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(C3(c4ccc(Br)cc4F)CC3)n2CCS1,,CCCCO,,,,val
US20090325924A1,CS(=O)(=O)c1ccc(-n2cc(CO)cn2)cc1.O=S(Cl)Cl>>CS(=O)(=O)c1ccc(-n2cc(CCl)cn2)cc1,,ClCCl,,CN(C)C=O,,val
US20120230951A1,CCOC(=O)[C@@H]1CC2(CCOCC2)CN1C(=O)[C@@H](NC(=O)OC)C(C)C>>COC(=O)N[C@H](C(=O)N1CC2(CCOCC2)CC1C(=O)O)C(C)C,,CC(C)(C)O,,C1CCOC1,[Li+].[OH-],val
US05866589,COC(=O)CN=[N+]=[N-].O=Cc1ccc(OCc2ccccc2)cc1>>COC(=O)C(=Cc1ccc(OCc2ccccc2)cc1)N=[N+]=[N-],,CO,,C[O-].[Na+],,val
US20080262096A1,CCOc1c(OCC)c(=O)c1=O.Cc1cc(N)ccc1O>>CCOc1c(Nc2ccc(O)c(C)c2)c(=O)c1=O,,CCO,,,,val
US20150148332A1,CCOC(=O)NC(=S)Nc1cc(Cl)ccn1.NO>>Nc1nc2cc(Cl)ccn2n1,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20030232875A1,CC(=O)Cl.CNC1c2ccccc2CC1NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1>>CC(=O)N(C)C1c2ccccc2CC1NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1,,CCOC(C)=O,ClCCl,CCN(CC)CC,O=C(O)C(F)(F)F,val
US06239131B1,CC(C)(C)OC(=O)NC1CNc2ccccc2NC1=O.CI>>CN1CC(NC(=O)OC(C)(C)C)C(=O)Nc2ccccc21,,CO,,O=C([O-])O.[Na+],,val
US20090099182A1,COc1cc(Cl)c(CN)c(Cl)c1.O=C1OCCC1C1CCCCC1>>COc1cc(Cl)c(CNC(=O)C(CCO)C2CCCCC2)c(Cl)c1,,Cc1ccccc1,,C[Al](C)C,Cl,val
US20110003787A1,COC[C@H](C)Oc1cc(Oc2ccc(S(=O)(=O)N(C)Cc3ccc(OC)cc3)nc2)cc(-c2ccc(C3=NC[C@H](C)O3)[nH]2)c1>>CNS(=O)(=O)c1ccc(Oc2cc(O[C@@H](C)COC)cc(-c3ccc(C4=NC[C@H](C)O4)[nH]3)c2)cn1,,O=C(O)C(F)(F)F,,,,val
US20070060563A1,CC(C)(C)OC(=O)CBr.O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2.[Br-],,ClC(Cl)Cl,,,,val
US20010021718A1,CCOC(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1.N>>CC(C)(C)OC(=O)C[C@@H](CCCc1ccccc1)c1nc(C(N)=O)no1,,CCO,,,,val
US20050119320A1,COc1ccc(-c2sc(NC(C)=O)nc2C)cc1.O=S(=O)(O)Cl>>COc1ccc(-c2sc(NC(C)=O)nc2C)cc1S(=O)(=O)Cl,,ClCCl,,,,val
US20140023611A1,O=C(NCc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(F)ccc2[N+](=O)[O-])c1.OCC(F)(F)F>>O=C(NCc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(OCC(F)(F)F)ccc2[N+](=O)[O-])c1,,C1CCOC1,O,[H-].[Na+],,val
US20050043388A1,NNS(=O)(=O)c1cccc(C(=O)O)c1.O=C1Nc2ccc(I)cc2C1=O>>O=C1Nc2ccc(I)cc2C1=NNS(=O)(=O)c1cccc(C(=O)O)c1,,CC(=O)O,,,,val
US05861417,COc1ccc(C2(CCO)CCN(C(=O)c3cc(-n4cnnn4)ccc3OC)C2)cc1OC.CS(=O)(=O)Cl>>COc1ccc(C2(CCOS(C)(=O)=O)CCN(C(=O)c3cc(-n4cnnn4)ccc3OC)C2)cc1OC,,ClCCl,,CCN(CC)CC,,val
US20070043028A1,C1CNCCNC1.CCOC(=O)CCCBr>>CCOC(=O)CCCN1CCCNCC1,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20090082254A1,CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)ON1C(=O)CCC1=O.N>>CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(N)=O,,ClCCl,O,,,val
US20130245021A1,COc1ccc(CNc2cc(C)c(Cl)nn2)c(OC)c1>>Cc1cc(N)nnc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030119844A1,CCCC(=O)Cl.COc1cc(OC(F)(F)F)ccc1-c1nc(OC)c(N)cc1C>>CCCC(=O)Nc1cc(C)c(-c2ccc(OC(F)(F)F)cc2OC)nc1OC,,ClCCl,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20040058964A1,Cc1cc(O)cc(=O)o1.NCc1cccc(F)c1>>Cc1cc(O)cc(=O)n1Cc1cccc(F)c1,,CCCCO,,,,val
US20100093730A1,FC(F)(F)c1ccc2c(c1)CNCC2.O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O>>O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)N1CCc2ccc(C(F)(F)F)cc2C1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20110294807A1,CN(C)/C=C/c1ccc(-c2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)cc1[N+](=O)[O-]>>O=c1c2ccccc2nc(-c2ccc3cc[nH]c3c2)n1-c1ccc(Cl)cc1,,CCO,CN(C)C=O,,,val
US20150087663A1,COc1ncnc(OC)c1C=O.NO>>COc1ncnc(OC)c1C=NO,,CCOC(C)=O,O,Cl,CC(=O)[O-].[Na+],val
US05885986,CCCNCCC.CN1Cc2c(-c3nc(CCl)co3)ncn2-c2ccsc2C1=O>>CCCN(CCC)Cc1coc(-c2ncn3c2CN(C)C(=O)c2sccc2-3)n1,,C1CCOC1,,,,val
US20120264737A1,Brc1ccc(Br)nc1.CC(C)(C)OC(=O)N1CCC(=O)CC1>>CC(C)(C)OC(=O)N1CCC(O)(c2ccc(Br)cn2)CC1,,Cc1ccccc1,,[Li]CCCC,,val
US20160052930A1,N#CCBr.NCc1ccccc1>>N#CCNCc1ccccc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US05998612,CC(=O)CC(=O)OCc1ccccc1.CI>>CCC(=O)CC(=O)OCc1ccccc1,,C1CCOC1,,[Li]CCCC,[H-].[Na+],val
US20100120846A1,Cc1cc2c(N)c(F)ccc2cn1.O=C(OC(=O)C(Cl)(Cl)Cl)C(Cl)(Cl)Cl>>Cc1cc2c(NC(=O)C(Cl)(Cl)Cl)c(F)ccc2cn1,,CC#N,,O,c1ccncc1,val
US20050020566A1,CC(=O)Cl.C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCOC(=O)C(C)(C)C)=C(c3ccc(N)cc3)C[C@H]12>>CC(=O)Nc1ccc(C2=C(C(=O)OCOC(=O)C(C)(C)C)N3C(=O)[C@H]([C@@H](C)O)[C@H]3C2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150225389A1,CC(C)(C)[Si](C)(C)N1C(=O)C[C@H]1C(=O)O.COc1ccc(CN(C(=O)OC(C)(C)C)c2cc(CBr)ccn2)cc1>>COc1ccc(CN(C(=O)OC(C)(C)C)c2cc(C[C@H]3C(=O)N([Si](C)(C)C(C)(C)C)[C@@H]3C(=O)O)ccn2)cc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20110306591A1,CC(C)(C)OC(=O)NC1CC(Oc2nccnc2Cl)C1.Cl>>Cl.NC1CC(Oc2nccnc2Cl)C1,,CO,,,,val
US05610120,CN=C=O.Nc1ccc(F)cc1F>>CNC(=O)Nc1ccc(F)cc1F,,Cc1ccccc1,,,,val
US06248755B1,CON(C)C(=O)[C@@H](O)CC1CCC1.O>>O=C(O)[C@@H](O)CC1CCC1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20080275043A1,CC(C)(C)OC(=O)CCCBr.O=C1C(Cc2c(Cl)ccc(-c3ccc(O)cc3)c2Cl)CCN1C1CCCCC1>>O=C(O)CCCOc1ccc(-c2ccc(Cl)c(CC3CCN(C4CCCCC4)C3=O)c2Cl)cc1,,C1CCOC1,,[I-].[Na+],O=C([O-])[O-].[Cs+].[Cs+],val
US20120238582A1,CCOC(=O)C1(c2ccc3nc(N)nc(C(=O)N4Cc5ccccc5C4)c3c2)CCC1>>Nc1nc(C(=O)N2Cc3ccccc3C2)c2cc(C3(C(=O)O)CCC3)ccc2n1,,C1CCOC1,,[Na+].[OH-],,val
US20070219198A1,Fc1ccc(N2CCNCC2)c(C(F)(F)F)c1.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=S(=O)(c1ccc(Cl)cc1)N1CCN(c2ccc(F)cc2C(F)(F)F)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110098275A1,CCc1nccc(-c2ccc(C(=O)OC)c(F)c2)c1C#Cc1ccc(N)nc1>>CCc1nccc(-c2ccc(C(=O)O)c(F)c2)c1C#Cc1ccc(N)nc1,,C1CCOC1,,[Na+].[OH-],,val
US20100322855A1,CC(CCC(=O)Nc1ccc(CC(CN2CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC2)NCC(=O)OC(C)(C)C)cc1)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)Nc1ccc(CC(CN2CCN(CC(=O)O)CCN(CC(=O)O)CC2)NCC(=O)O)cc1)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C,,C1COCCO1,,CCOCC,Cl,val
US05114944,CNC.O=C(O)Cc1c(-c2ccc(Cl)cc2)nn2cccnc12>>CN(C)C(=O)Cc1c(-c2ccc(Cl)cc2)nn2cccnc12,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20160002255A1,COC(=O)c1nc(Br)ccc1O>>OCc1nc(Br)ccc1O,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160264598A1,CC(C)(C)OC(=O)c1cccc(CC(NC(=O)CCCNS(C)(=O)=O)B2OC3CC4CC(C4(C)C)C3(C)O2)c1>>CS(=O)(=O)NCCCC(=O)N[C@H]1Cc2cccc(C(=O)O)c2OB1O,,ClCCl,,BrB(Br)Br,,val
US20040157891A1,CCC(=O)Cl.COc1ccc(-c2nc(CN)oc2-c2ccc(OCc3ccccc3)cc2)cc1>>CCC(=O)NCc1nc(-c2ccc(OC)cc2)c(-c2ccc(OCc3ccccc3)cc2)o1,,CN(C)C=O,,c1ccncc1,,val
US20050070441A1,Cc1cc(O)n[nH]1.Fc1c(Cl)cc(C(F)(F)F)cc1Cl>>Cc1cc(Oc2c(Cl)cc(C(F)(F)F)cc2Cl)n[nH]1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US05364871,CCC(=O)NCc1cccc(-c2csc(NC(=S)NC(=O)c3ccccc3)n2)n1>>CCC(=O)NCc1cccc(-c2csc(NC(N)=S)n2)n1,,CO,O,[Na+].[OH-],,val
US20140031360A1,CC(C)(C)OC(=O)NC1CCN(c2cncc(B3OC(C)(C)C(C)(C)O3)c2)CC1.Cc1ccc(S(=O)(=O)n2cc(I)c3nc(-c4c(F)cccc4F)ccc32)cc1>>Cc1ccc(S(=O)(=O)n2cc(-c3cncc(N4CCC(NC(=O)OC(C)(C)C)CC4)c3)c3nc(-c4c(F)cccc4F)ccc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20060148858A1,COc1ccc(OCc2ccccc2)cc1C=O.[C-]#[N+]CS(=O)(=O)c1ccccc1C>>COc1ccc(OCc2ccccc2)cc1CC#N,,CO,COCCOC,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20090143423A1,C#CCBr.Oc1ccccc1OC(F)(F)F>>C#CCOc1ccccc1OC(F)(F)F,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20090264485A1,Cn1nccc1CCS(=O)Cc1ccc(OCc2coc(/C=C/c3ccc(C(F)(F)F)cc3)n2)cc1.O=C(OO)c1cccc(Cl)c1>>Cn1nccc1CCS(=O)(=O)Cc1ccc(OCc2coc(C=Cc3ccc(C(F)(F)F)cc3)n2)cc1,,ClCCl,,,,val
US05681820,CCOC(=O)CC(NC(=O)CNC(=O)OC(C)(C)C)c1cccnc1>>CCOC(=O)CC(NC(=O)CN)c1cccnc1,,C1COCCO1,,Cl,,val
US20070208054A1,CC(C)(C)OC(=O)N(CC(=O)OCc1ccccc1)Cc1ccc(Br)cc1>>CC(C)(C)OC(=O)N(CC(=O)O)Cc1ccc(Br)cc1,,C1CCOC1,,[Li+].[OH-],,val
US20150099771A1,COC(=O)COC(Cc1cccnc1C(=O)OC)c1ccccc1>>COC(=O)C1=C(O)c2ncccc2CC(c2ccccc2)O1,,Cc1ccccc1C,,C1CCOC1,CC(C)(C)[O-].[K+],val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](O)CC2)c2ccnn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](O)CC2)c2ccnn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US05922725,CON.O=Cc1ccc2c(c1)ncn2-c1cccc(Br)c1>>CON=Cc1ccc2c(c1)ncn2-c1cccc(Br)c1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20050267152A1,[N-]=[N+]=NC[C@H](O)CN1CCCCC1>>NC[C@H](O)CN1CCCCC1,[Pd],CCO,,,,val
US20150157622A1,COC(=O)[C@@H]1[C@@H](OC)[C@H](OC(=O)c2ccc(CNC(=O)OC(C)(C)C)cc2)C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]21>>COC(=O)[C@@H]1[C@@H](OC)[C@H](OC(=O)c2ccc(CN)cc2)C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]21,,ClCCl,,CCOC(C)=O,Cl,val
US20030007927A1,COC(=O)C(Cc1ccccc1OCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NC(Cc1ccccc1OCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O,,C1CCOC1,,O,[Li+].[OH-],val
US20160221972A1,COC(=O)c1ccc2c(c1)OC[C@H](C)NC2.COc1ccc(CBr)cc1>>COC(=O)c1ccc2c(c1)OC[C@H](C)N(Cc1ccc(OC)cc1)C2,,C1CCOC1,,[H-].[Na+],,val
US20050165006A1,O=CN1CCNCC1.O=[N+]([O-])c1ccc2nc(Br)cc(Br)c2c1>>O=CN1CCN(c2cc(Br)c3cc([N+](=O)[O-])ccc3n2)CC1,,CN(C)C=O,,,,val
US20070293516A1,CC(C)n1nc(I)c2c(N)ncnc21.CCO.OB(O)c1cccc2[nH]ccc12>>Nc1ncnc2c1c(-c1cccc3[nH]ccc13)nn2C1CCCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20110172191A1,N[C@H]1CN(Cc2ccccc2)C[C@H]1O.O=C(n1ccnc1)n1ccnc1>>O=C1N[C@H]2CN(Cc3ccccc3)C[C@H]2O1,,CN(C)C=O,,,,val
US20150166564A1,COC[C@H](N1C[C@@H](NC(=O)OC(C)(C)C)[C@H](c2ccc(F)c(F)c2)C1)C(F)(F)F.Cl.ClCCl>>COC[C@H](N1C[C@@H](N)[C@H](c2ccc(F)c(F)c2)C1)C(F)(F)F.Cl.Cl,,ClCCl,,,,val
US20040058820A1,CCC(C)(Oc1ccccn1)C(=O)OCc1ccccc1>>CCC(C)(Oc1ccccn1)C(=O)O,[Pd],CO,,,,val
US06329381B1,CN(C)CCCCl.Nc1nc(S)nc2c1nc(O)n2Cc1ccccc1>>CN(C)CCCSc1nc(N)c2ncn(Cc3ccccc3)c2n1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US06432880B1,CS(=O)(=O)Cl.Oc1cnc(Cl)c(Cl)c1>>CS(=O)(=O)Oc1cnc(Cl)c(Cl)c1,,ClCCl,,CCN(CC)CC,,val
US20120238600A1,CC(C)(C)OC(=O)N1C2C=C([Sn](C)(C)C)CC1CC2.O=C(NCc1ccc(F)c(Br)c1)C(F)(F)F>>CC(C)(C)OC(=O)N1C2C=C(c3cc(CNC(=O)C(F)(F)F)ccc3F)CC1CC2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20020065315A1,CC(C)c1cccc(C(C)C)c1N.ClCc1ccccn1>>CC(C)c1cccc(C(C)C)c1NCc1ccccn1,,CN(C)C=O,O,CCN(CC)CC,,val
US20090149475A1,N=CN.Nc1c(N)n(Cc2nc3ccccc3[nH]2)c(=S)[nH]c1=O>>O=c1[nH]c(=S)n(Cc2nc3ccccc3[nH]2)c2nc[nH]c12,,CS(C)=O,,CC(=O)O,,val
US05972965,COc1cccc(CCl)c1.O=C1CCC(c2nc(-c3ccccc3)c(-c3ccccc3)o2)N1>>COc1cccc(CN2C(=O)CCC2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1,,C1CCOC1,,[H-].[Na+],,val
US20100063037A1,O=C(CCl)Nc1ccc2c(c1)COC(N[C@@H]1CCc3ccccc31)=N2.O=S1(=O)CCNCC1>>O=C(CN1CCS(=O)(=O)CC1)Nc1ccc2c(c1)COC(N[C@@H]1CCc3ccccc31)=N2,,CC#N,,,,val
US04753962,CC(=O)c1ccc(OCc2ccccc2)c(CO)c1.CC(=O)c1ccc(OCc2ccccc2)c(NS(C)(=O)=O)c1>>CS(=O)(=O)Nc1cc(C(=O)C=O)ccc1OCc1ccccc1,,CCO,O,,,val
US20150238601A1,CC(C)NC(=O)COc1cccc(B2OC(C)(C)C(C)(C)O2)c1.Clc1cc(Cl)nc(I)n1>>CC(C)NC(=O)COc1cccc(-c2nc(Cl)cc(Cl)n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100190766A1,COC(=O)[C@@H](NC(=O)c1ccc(C#C/C=C/C2CC2)cc1)C(C)(C)O.NO>>CC(C)(O)[C@H](NC(=O)c1ccc(C#C/C=C/C2CC2)cc1)C(=O)NO,,CC(C)O,,,,val
US07012080B2,CC(C)(O)CN1CCC(CN(Cc2ccccc2)Cc2ccccc2)CC1.CI>>COC(C)(C)CN1CCC(CN(Cc2ccccc2)Cc2ccccc2)CC1,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20120202785A1,C[C@H](N)c1nc2ccc(F)cc2n1Cc1ccccc1.N#Cc1c(N)ncnc1Cl>>C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2n1Cc1ccccc1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20020035233A1,O=P(O)(O)c1ccccc1-c1ccccc1O>>O=[PH]1Oc2ccccc2-c2ccccc21,,C1CCOC1,,,,val
US05948803,COc1ccc(C2SC(=O)NC2=O)cc1C(=O)O.NCc1ccc(C(F)(F)F)cc1>>COc1ccc(C2SC(=O)NC2=O)cc1C(=O)NCc1ccc(C(F)(F)F)cc1,,CN(C)C=O,O,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US05618811,Cc1ccc(CCCC(=O)O)cc1.c1ccccc1>>CC(=O)Oc1cccc2ccc(C)cc12,,c1ccccc1,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US04210754,NCCN1CCOCC1.O=C(Oc1ccc([N+](=O)[O-])cc1)c1ccc(Cl)cc1>>O=C(NCCN1CCOCC1)c1ccc(Cl)cc1,,C1CCOC1,,,,val
US20140179666A1,C[C@@H]1COCCN1C[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ncc(Cc3ccc(F)cc3)cc21>>C[C@@H]1COCCN1C[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ncc(Cc3ccc(F)cc3)cc21,,O,,Cl,Cl,val
US20160235734A1,CC(C)(C)OC(=O)NCCCNC(=O)c1cccc(C(O)(C(=O)O)c2ccccc2)c1.OCC1CCN(Cc2ccccc2)CC1>>CC(C)(C)OC(=O)NCCCNC(=O)c1cccc(C(O)(C(=O)OCC2CCN(Cc3ccccc3)CC2)c2ccccc2)c1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20090018103A1,COCCCOC(c1ccccc1)C1CCCN(C(=C[N+](=O)[O-])N[C@H](CNC(=O)OC(C)(C)C)CC2CCCCC2)C1>>COCCCOC(c1ccccc1)C1CCCN(C(=C[N+](=O)[O-])N[C@H](CN)CC2CCCCC2)C1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20090023756A1,Cc1cccc(NN)c1.O=C1CCN(C(=O)OCc2ccccc2)CC1>>Cc1ccc2c3c([nH]c2c1)CCNC3,,c1ccncc1,,,,val
US20040102484A1,CC(C)c1cccc(OCC(=O)NCCCC(=O)O)c1.O=[N+]([O-])c1cccc(S(=O)(=O)CCO)c1>>CC(C)c1cccc(OCC(=O)NCCCC(=O)OCCS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US05874464,CCCCCCCCCCCCCC(=O)OCC1(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CCC(=O)O1>>CCCCCCCCCCCCCC(=O)OCC1(CO)CCC(=O)O1,,C1CCOC1,,,,val
US05698584,CCN(CC)CC(=O)OC(C)(C)C(=O)c1ccc(S(C)(=O)=O)cc1>>CCN(CC)C1=C(c2ccc(S(C)(=O)=O)cc2)C(C)(C)OC1=O,,CCOC(C)=O,CN(C)C=O,,,val
US20090044345A1,CN.ClCc1cc(-n2cccc2)ccn1>>CNCc1cc(-n2cccc2)ccn1,,CC(C)O,,,,val
US20150336925A1,CC(C)(C)OC(=O)N1CCC(S(N)(=O)=O)CC1.Cc1cc(OCCCc2c(C(=O)O)[nH]c3cc(Cl)ccc23)cc(C)c1Cl>>Cc1cc(OCCCc2c(C(=O)NS(=O)(=O)C3CCNCC3)[nH]c3cc(Cl)ccc23)cc(C)c1Cl,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20070010526A1,COc1ccc(N2CCN(C)CC2)c2c1CCN(C(=O)Cc1ccc(N)cc1)C2.O=C(Cl)Cc1ccccc1>>COc1ccc(N2CCN(C)CC2)c2c1CCN(C(=O)Cc1ccc(NC(=O)Cc3ccccc3)cc1)C2,,ClCCl,,CCN(CC)CC,CO,val
US20150111870A1,COc1nc2ccc(C(O)(c3ccc(C)nc3C)c3cnnn3C)cc2c(Cl)c1OCC(C)(C)OCc1ccccc1>>COc1nc2ccc(C(O)(c3ccc(C)nc3C)c3cnnn3C)cc2c(Cl)c1OCC(C)(C)O,[Pd],CO,,,,val
US20060094767A1,C=C(C)Cn1c(=O)oc2ccccc21.O=C(OO)c1cccc(Cl)c1>>CC1(Cn2c(=O)oc3ccccc32)CO1,,ClCCl,,,,val
US20110301161A1,CCOC(=O)C(=O)Cl.COc1cncc(-c2ccc3c(c2)nc(-c2cccc(C(=N)NO)c2)n3C(C)(C)C)c1>>CCOC(=O)c1nc(-c2cccc(-c3nc4cc(-c5cncc(OC)c5)ccc4n3C(C)(C)C)c2)no1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20090054405A1,CC(=O)Nc1nc2ccc(B3OC(C)(C)C(C)(C)O3)cc2s1.Cc1ccc(S(=O)(=O)Nc2cncc(Br)c2)cc1>>CC(=O)Nc1nc2ccc(-c3cncc(NS(=O)(=O)c4ccc(C)cc4)c3)cc2s1,[Pd],C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US06353095B1,CC(=O)N[C@H]1[C@@H](OC(C)=O)O[C@@H](COC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O>>CC(=O)N[C@H]1[C@@H](O)O[C@@H](CO)[C@H](O)[C@H]1O,,C1CCOC1,O,[Li+].[OH-],,val
US20130324579A1,CC(C)(C)OC(=O)NCCn1cc([N+](=O)[O-])cn1>>CC(C)(C)OC(=O)NCCn1cc(N)cn1,[Pd],CO,,,,val
US20120184547A1,CSc1ncc2ccc(=O)n(Cc3ccccc3Br)c2n1.O=S([O-])OO>>CS(=O)(=O)c1ncc2ccc(=O)[nH]c2n1,,O,,CO,,val
US20040087632A1,CCOC(=O)CNc1ccccc1.CI>>CCOC(=O)CN(C)c1ccccc1,,CCOC(C)=O,Cc1ccccc1,,,val
US20130217680A1,CC(C)(C)OC(=O)N1CCNC2CC21.Cc1c([C@@H]2CO2)ccc2c1COC2=O>>Cc1c([C@@H](O)CN2CCN(C(=O)OC(C)(C)C)C3CC32)ccc2c1COC2=O,,CCO,,,,val
US20090318690A1,CN(C)Cc1cc2c(CCC3CCN(C(=O)OC(C)(C)C)CC3)noc2cc1OCC1CC1>>CN(C)Cc1cc2c(CCC3CCNCC3)noc2cc1OCC1CC1,,CO,,Cl,,val
US20110002855A1,CC#N.CCOC(=O)c1c(N)sc2c1CCN(C(=O)OCC)C2>>CCOC(=O)N1CCc2c(sc3nc(C)nc(O)c23)C1,,C1COCCO1,Cl,,,val
US20060111402A1,CI.FC(F)(F)Cc1nc2cc(Cl)c(Cl)cc2[nH]1>>Cn1c(CC(F)(F)F)nc2cc(Cl)c(Cl)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20130150339A1,Brc1ccnc2cc(SCc3ccccc3)ncc12.COc1cc(C(F)(F)F)ccc1B(O)O>>COc1cc(C(F)(F)F)ccc1-c1ccnc2cc(SCc3ccccc3)ncc12,,O,,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20090062360A1,N#Cc1ccc(C2=NC3(CCCCC3)N(CC(=O)O)C2=O)cc1.O=C(Cl)C(=O)Cl>>N#Cc1ccc(C2=NC3(CCCCC3)N(CC(=O)Cl)C2=O)cc1,CN(C)C=O,ClCCl,,,,val
US20130116246A1,C[C@H]1COCCN1C(=O)c1ccc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3C=O)cn(C)c2=O)nc1>>C[C@H]1COCCN1C(=O)c1ccc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cn(C)c2=O)nc1,,CO,ClCCl,[BH4-].[Na+],,val
US20150368254A1,C[C@@H](O)[C@H](NC(=O)CN1CC2(CCCN2C(=O)OCc2ccccc2)C1=O)c1nnco1>>C[C@@H](O)[C@H](NC(=O)CN1CC2(CCCN2)C1=O)c1nnco1,[Pd],CO,,,,val
US20030004181A1,COC(=O)CCNc1ccccn1.Cn1c(COc2ccc(C#N)cc2)nc2nc(C(=O)O)ccc21>>COC(=O)CCN(C(=O)c1ccc2c(n1)nc(COc1ccc(C#N)cc1)n2C)c1ccccn1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20150175594A1,Cc1noc(-c2c(NC(=O)C3=C(C(=O)O)CCC3)sc3c2CCC3)n1.O=C1OC(=O)C2=C1C1CCC2CC1>>Cc1noc(-c2c(NC(=O)C3=C(C(=O)O)C4CCC3CC4)sc3c2CCC3)n1,,CCCCCC,CCOC(C)=O,,,val
US20070203157A1,C1CCNC1.CS(=O)(=O)Cl>>CS(=O)(=O)N1CCCC1,,ClCCl,,CCN(CC)CC,,val
US20140094459A1,CC(C)(C)OC(=O)N1CCC[C@@H]1Cn1nc(I)c2c(N)ncnc21.CC1(C)OB(c2ccc(Oc3c(F)cccc3F)cc2)OC1(C)C>>CC(C)(C)OC(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3c(F)cccc3F)cc2)c2c(N)ncnc21,,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20050272763A1,CCN(CC)CC.CCOC(=O)c1oc2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)cc2c1NC(=O)C(F)(F)F>>CCN(CC)C(=O)c1oc2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)cc2c1NC(=O)C(F)(F)F,,Cc1ccccc1,ClCCl,C[Al](C)C,,val
US20110233048A1,C1CCNCC1.O=C1c2ccccc2C(=O)c2cc(CCOC(=O)n3ccnc3)ccc21>>O=C1c2ccccc2C(=O)c2cc(CCOC(=O)N3CCCCC3)ccc21,,CN(C)C=O,,,,val
US20130072495A1,COc1ccc(F)c(Cl)c1C(C)C(O)c1cc(Br)cnc1F>>COc1ccc(F)c(Cl)c1C(C)C(=O)c1cc(Br)cnc1F,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20130296290A1,CC(C)(C)[Si](C)(C)Cl.N#CCCO>>CC(C)(C)[Si](C)(C)OCCC#N,,CN(C)C=O,,c1c[nH]cn1,,val
US20060004017A1,COc1ccc2cc(F)c(C)nc2c1>>Cc1nc2cc(O)ccc2cc1F,,ClCCl,,BrB(Br)Br,CO,val
US20090318690A1,C=CCc1cc(OC(C)=O)cc2c(C)noc12>>C=CCc1cc(O)cc2c(C)noc12,,O,,CO,Cl,val
US20150087646A1,CC(C)(C)OC(=O)NNc1ccc(C(F)(F)F)cc1.Cc1ccc(CNC(=O)C(F)(F)F)c(C)c1C(=O)N=C=O>>Cc1ccc(CNC(=O)C(F)(F)F)c(C)c1-c1nn(-c2ccc(C(F)(F)F)cc2)c(=O)[nH]1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04662933,CC(C)(C)NS(=O)(=O)c1ccccc1CCO.CS(=O)(=O)Cl>>CC(C)(C)NS(=O)(=O)c1ccccc1CCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US05853699,CCCO.CCOc1ccc(C(=O)C(=O)O)cc1>>CCCOC(=O)C(=O)c1ccc(OCC)cc1,,O,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US20110009454A1,COCc1ccc(C(=O)O)c(N)n1.NCc1cccc(Oc2ccccc2F)c1>>COCc1ccc(C(=O)NCc2cccc(Oc3ccccc3F)c2)c(N)n1,,CN(C)C=O,O,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20120010228A1,O=C(Cl)OCc1ccccc1.O=C1NCN(c2ccc(F)cc2)C12CCNCC2>>O=C(OCc1ccccc1)N1CCC2(CC1)C(=O)NCN2c1ccc(F)cc1,,ClCCl,,c1ccncc1,,val
US04472305,CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)OC(C)(C)C)C(N)=O>>CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CN)C(N)=O,,CC(=O)O,,Cl,,val
US20090275602A1,COC(=O)[C@H](Cc1ccc2c(c1)OC(C)(C)O2)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)[C@@H](Cc1ccc2c(c1)OC(C)(C)O2)C(=O)O,,C1CCOC1,,O,[Li+].[OH-],val
US04230703,COC(=O)Cc1ccc2c(c1)C(=O)c1ccccc1CN2C.O=C1CCC(=O)N1Cl>>CN1Cc2ccccc2C(=O)c2cc(CC(=O)O)cc(Cl)c21,,ClC(Cl)Cl,,,,val
US04587342,COS(=O)(=O)OC.O=Cc1ccc(O)c2ncccc12>>COc1ccc(C=O)c2cccnc12,,CS(C)=O,,C[O-].[Na+],,val
US20080167307A1,CC(C)(C)OC(=O)C(C)(C)Sc1nc(CC(=O)O)cs1.Cn1nc(-c2ccc(Cl)cc2)cc1N>>Cn1nc(-c2ccc(Cl)cc2)cc1NCCc1csc(SC(C)(C)C(=O)O)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04021479,O=C(O)CCC(O)c1ccc(-c2ccccc2[N+](=O)[O-])cc1>>Nc1ccccc1-c1ccc(C(O)CCC(=O)O)cc1,O=[Pt]=O,CO,,,,val
US20160151249A1,C=C(C)C(=O)OCCNC(=O)NCCCCCCP(=O)(OCC)OCC>>C=C(C)C(=O)OCCNC(=O)NCCCCCCP(=O)(O)O,,ClCCl,,C[Si](C)(C)Br,,val
US20050228013A1,O=C=O.c1cnc2ccoc2c1>>O=C(O)c1nc2ccccc2o1,,C1CCOC1,,[Li]CCCC,,val
US20160115125A1,COC(=O)c1cc(S(=O)(=O)Cl)cn1C.C[C@@H](N)C(F)(F)F>>COC(=O)c1cc(S(=O)(=O)N[C@H](C)C(F)(F)F)cn1C,,CC#N,,CCN(C(C)C)C(C)C,,val
US20070185093A1,CC(C)(C)C(=O)OCn1nnc(-c2cccc(NC(=O)CN3NC(C4CCCCC4)c4ccccc4N(CC(=O)C4CCCC4)C3=O)c2)n1>>O=C(CN1NC(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2nn[nH]n2)c1,,N,,,,val
US20070167443A1,BrCc1cccc(Br)n1.CCOC(=O)c1c[nH]c2ccccc2c1=O>>CCOC(=O)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20020068734A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCNc1cc2ncnc(N3CCNCC3)c2cc1[N+](=O)[O-]>>CCNc1cc2ncnc(N3CCN(C(=O)OC(C)(C)C)CC3)c2cc1[N+](=O)[O-],,ClCCl,,CCN(CC)CC,,val
US20070124152A1,CCOC(=O)c1ncc(Cc2ccc(F)cc2)cc1N.CSCCC=O>>CCOC(=O)c1ncc(Cc2ccc(F)cc2)cc1NCCCSC,,ClCCCl,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20050059662A1,CS(=O)(=O)Cl.NC1CN(C(c2ccccc2)c2ccccc2)C1>>CS(=O)(=O)NC1CNC1,,ClCCl,,CCN(CC)CC,,val
US20130029973A1,COC(=O)c1ccc(CCCc2ccc(NC(=O)c3c(N)sc4c3CCCC4)cc2)cc1.O=C(Cl)c1cccc(S(=O)(=O)Cl)c1>>COC(=O)c1ccc(CCCc2ccc(NC(=O)c3c(NC(=O)c4cccc(S(=O)(=O)Cl)c4)sc4c3CCCC4)cc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20120190665A1,C1CNC1.CN(C)C=O.COc1ccc(Cl)cc1-c1[nH]ncc1NC(=O)c1cnn2cccnc12.ClC[C@@H]1CO1>>COc1ccc(Cl)cc1-c1nn(C[C@@H](O)CN2CCC2)cc1NC(=O)c1n[nH]c2cncnc12,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04209515,CNC.COC(=O)c1nc(CI)n(-c2ccc(Cl)cc2C(=O)c2ccccc2Cl)n1>>COC(=O)c1nc(CN(C)C)n(-c2ccc(Cl)cc2C(=O)c2ccccc2Cl)n1,,CO,,,,val
US20140378459A1,CC(C)(C)OC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.COc1ccc(CC=O)c(Cl)c1>>COc1ccc(C/C=C/C(=O)OC(C)(C)C)c(Cl)c1,,Cc1ccccc1,,,,val
US20140343052A1,CC(C)(C)N.COc1ccc(-c2ccc(C)c(C(=O)NS(C)(=O)=O)n2)c(C)c1C1C2=C(CC(C)(C)CC2=O)OC2=C1C(=O)CC(C)(C)C2>>CC(C)(C)N.COc1ccc(-c2ccc(C)c(C(=O)NS(C)(=O)=O)n2)c(C)c1C1C2=C(CC(C)(C)CC2=O)OC2=C1C(=O)CC(C)(C)C2,,CCO,,CCOCC,,val
US20060287324A1,Clc1ccc(-c2cc3nnc(Cl)n3nc2-c2ccccc2Cl)cc1.OC1CCCCC1>>Clc1ccc(-c2cc3nnc(OC4CCCCC4)n3nc2-c2ccccc2Cl)cc1,,C1CCOC1,,[Na],,val
US20130005707A1,CC(C)(C)OC(=O)N1CCC(NC(=O)c2ccc(Nc3nc4cccc(-c5ccccc5)n4n3)cc2)CC1>>O=C(NC1CCNCC1)c1ccc(Nc2nc3cccc(-c4ccccc4)n3n2)cc1,,Cl,,,,val
US05389641,CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1>>CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1,,CO,,[Na+].[OH-],,val
US20140323303A1,COC1=C(c2c(C)cc(Br)cc2C)C(=O)CC1.O=CC1CCOCC1>>COC1=C(c2c(C)cc(Br)cc2C)C(=O)C(C(O)C2CCOCC2)C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20070232583A1,CC(C)(C)NS(=O)(=O)c1cccc(-c2cc(-c3nc(-c4ccc(Cl)c(Cl)c4)cc(C(F)(F)F)n3)ccn2)c1>>NS(=O)(=O)c1cccc(-c2cc(-c3nc(-c4ccc(Cl)c(Cl)c4)cc(C(F)(F)F)n3)ccn2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04824840,CC(=O)OC(C)=O.O=C1CCc2c(cccc2OCCCN2CCNCC2)N1>>CC(=O)N1CCN(CCCOc2cccc3c2CCC(=O)N3)CC1,,CC(=O)O,,,,val
US20040102636A1,Cc1ccc(O)cc1.O=[N+]([O-])c1ccc(Cl)nc1>>Cc1ccc(Oc2ccc([N+](=O)[O-])cn2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040023961A1,CC(C)(C)OC(=O)Nc1ccc(OCc2ccncc2)c2ccccc12>>Nc1ccc(OCc2ccncc2)c2ccccc12,,C1COCCO1,CCOC(C)=O,Cl,[Na+].[OH-],val
US20090227627A1,O=[N+]([O-])c1cc(F)c(Sc2cccc(C3OCCCO3)c2)cc1CO>>O=Cc1cc(Sc2cccc(C3OCCCO3)c2)c(F)cc1[N+](=O)[O-],O=[Mn]=O,ClC(Cl)Cl,,,,val
US20040242596A1,CCCC(OC)(OC)OC.Cc1nsc(N)c1C(N)=O>>CCCc1nc2snc(C)c2c(=O)[nH]1,,CC(=O)OC(C)=O,,,,val
US20040058905A1,CC#N.C[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H](C)N1.O=C1c2ccccc2C(=O)N1CCBr>>C[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H](C)N1CCN1C(=O)c2ccccc2C1=O.N,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20060094769A1,CCOC(=O)CCCCN(CCc1cc(F)ccc1OC)Cc1ccc(C(=O)OC)cc1>>COC(=O)CCCCN(CCc1cc(F)ccc1O)Cc1ccc(C(=O)OC)cc1,,ClCCl,,BrB(Br)Br,CO,val
US20140243283A1,CC(=O)OC[C@H]1O[C@H](C/C=C/c2ccc(/C=C/C[C@H]3O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3OC(C)=O)cc2)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>OC[C@H]1O[C@H](C/C=C/c2ccc(/C=C/C[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)cc2)[C@@H](O)[C@@H](O)[C@@H]1O,,CO,,CO[Na],,val
US04808620,CC(C)(C)c1cc(C(=O)c2cccnc2Cl)cc(C(C)(C)C)c1O.NN>>CC(C)(C)c1cc(-c2n[nH]c3ncccc23)cc(C(C)(C)C)c1O,,c1ccncc1,,O,,val
US20070149533A1,CC(C)(C)OC(=O)NCc1cc(N)cc(C(F)(F)F)c1.O=C(O)C1CCc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2C1>>CC(C)(C)OC(=O)NCc1cc(NC(=O)C2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110046169A1,CCOC(=O)c1cn(C)n(-c2ccccc2Cl)c1=O>>Cn1cc(C(=O)O)c(=O)n1-c1ccccc1Cl,,CO,,C1CCOC1,[Na+].[OH-],val
US20030034722A1,CCCCCCCCCCOc1c(C(=O)OCC)[nH]c(C(=O)OCC)c1OCCCCCCCCCC>>CCCCCCCCCCOc1c(C(=O)O)[nH]c(C(=O)O)c1OCCCCCCCCCC,,CCO,,[Na+].[OH-],,val
US20060069256A1,Cc1csc(N)n1.O=C1CCCCC1>>Cc1csc(NC2CCCCC2)n1,,C1CCOC1,CCOC(C)=O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05726184,O=C1CCCc2ccc(OCc3ccncc3)cc21>>OC1CCCc2ccc(OCc3ccncc3)cc21,,C1CCOC1,Cc1ccccc1,CC(C)C[Al+]CC(C)C.[H-],,val
US03948904,ClCOCCl.O=C(O)c1cccs1>>O=C(O)c1ccc(CCl)s1,,ClC(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20060217387A1,CS(=O)(=O)OS(C)(=O)=O.Nc1ccc(C#Cc2cnn3c(C(F)(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)cn1>>CS(=O)(=O)N(c1ccc(C#Cc2cnn3c(C(F)(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)cn1)S(C)(=O)=O,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20080021032A1,COC(=O)C(CC1CCCC1)c1ccc2c(c1)CCS2(=O)=O>>O=C(O)C(CC1CCCC1)c1ccc2c(c1)CCS2(=O)=O,,CCO,O,[Li+].[OH-],,val
US20100168136A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCCC1(CCOCc2ccccc2)OCCO1>>Cc1ccc(S(=O)(=O)OCCC2(CCOCc3ccccc3)OCCO2)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US03962224,COP(=O)(CNCc1ccccc1)OC.Cl>>COP(=O)(CN)OC.Cl,[Pd],CO,c1ccccc1,C,,val
US20150038488A1,COc1ccc([C@@H](C)N2C[C@H](C(=O)O)CC2=O)cc1>>COc1ccc([C@@H](C)N2C[C@H](CO)CC2=O)cc1,,C1CCOC1,,CCOC(C)=O,O,val
US20050176742A1,COc1cc(-c2nc3sc4c(c3c(=O)n2Cc2ccccc2)C(C)CC(Br)C4=O)c(Br)c(OC)c1OC>>COc1cc(-c2nc3sc4c(O)ccc(C)c4c3c(=O)n2Cc2ccccc2)c(Br)c(OC)c1OC,,CCO,,[Na+].[OH-],,val
US20050119320A1,CCNC(=O)Nc1nc(C)c(-c2ccc(OC)cc2)s1.O=S(=O)(O)Cl>>CCNC(=O)Nc1nc(C)c(-c2ccc(OC)c(S(=O)(=O)Cl)c2)s1,,ClCCl,,,,val
US20040110749A1,Cn1nc(C(F)F)c(C=O)c1Cl>>Cn1nc(C(F)F)c(CO)c1Cl,,CO,,O,[BH4-].[Na+],val
US20120214766A1,CCOC(=O)c1nn(CC2CCOCC2)c2c1CC1CC21>>O=C(O)c1nn(CC2CCOCC2)c2c1C[C@H]1C[C@@H]21,,C1CCOC1,O,[Li+].[OH-],,val
US20010027196A1,CS(=O)c1nc(N)nc(-n2cccn2)c1C#N.Cc1ccc(CN)cc1C>>Cc1ccc(CNc2nc(N)nc(-n3cccn3)c2C#N)cc1C,,COCCOC,,,,val
US20110257189A1,O=c1[nH]cc(Cc2cccc([N+](=O)[O-])c2)n2cc(-c3c[nH]c4ncccc34)cc12>>Nc1cccc(Cc2c[nH]c(=O)c3cc(-c4c[nH]c5ncccc45)cn23)c1,[Ni],CO,,,,val
US20100004235A1,CCCCC(CC)COC(=O)Cl.NC(=NO)c1nn(Cc2ccccc2F)c2ncccc12>>O=c1[nH]c(-c2nn(Cc3ccccc3F)c3ncccc23)no1,,CN(C)C=O,,O,c1ccncc1,val
US20160024044A1,CN(CC(c1ccc(Cl)c(Cl)c1)C(O)c1ccccc1S(C)=O)C(=O)[O-]>>CNC[C@H](c1ccc(Cl)c(Cl)c1)[C@H](O)c1ccccc1S(C)=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160016951A1,Cn1cc(-c2ccc(-c3c[n+]([O-])cc4ccc(C(=O)N5CCC5)cc34)cc2)cn1.NCCO>>Cn1cc(-c2ccc(-c3cnc(N)c4ccc(C(=O)N5CCC5)cc34)cc2)cn1,,O,c1ccncc1,Cc1ccc(S(=O)(=O)Cl)cc1,,val
US20160221975A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)CC1,CN(C)c1ccncc1,ClCCl,,CCCCCC,CCOC(C)=O,val
US20140323528A1,CI.COc1c(C(=O)Nc2c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2Br)cccc1[N+](=O)[O-]>>COc1c(C(=O)N(C)c2c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2Br)cccc1[N+](=O)[O-],,CN(C)C=O,,[H-].[Na+],,val
US20080153814A1,CC1=Cc2ccc(Cl)cc2C(c2ccc([N+](=O)[O-])c(C)c2)=NN1C(=O)Oc1ccccc1.CN>>CNC(=O)N1N=C(c2ccc([N+](=O)[O-])c(C)c2)c2cc(Cl)ccc2C=C1C,,CCO,,,,val
US20110281870A1,N[C@H]1CC[C@@H]2CN(Cc3ccccc3)C[C@H]12.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>N[C@H]1CC[C@@H]2CN(Cc3ccccc3)C[C@H]12.O=C(O)[C@H](O)[C@@H](O)C(=O)O,,CCO,,,,val
US08742113B2,CCOC(=O)C1=C(NC2CCCCCC2)OC(=Cc2c[nH]c3ncccc23)C1=O>>O=C1C=C(NC2CCCCCC2)OC1=Cc1c[nH]c2ncccc12,,CN(C)C=O,,,,val
US20130131039A1,C=O.N#CCC(C1CC1)n1cc(-c2nc(-c3ccc4c(c3)CCNC4)cc3nccn23)cn1>>CN1CCc2cc(-c3cc4nccn4c(-c4cnn(C(CC#N)C5CC5)c4)n3)ccc2C1,,CO,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160002242A1,CC(C)(C)OC(=O)N1CCC(CCCn2cc([N+](=O)[O-])cn2)CC1>>CC(C)(C)OC(=O)N1CCC(CCCn2cc(N)cn2)CC1,[Pd],CO,,,,val
US20100267688A1,N#CCC#N.O=C1CCC2(CC1)OCCO2>>N#CC(C#N)C1CCC2(CC1)OCCO2,,CC(C)O,,[BH4-].[Na+],,val
US05605914,CCCCCN.COc1ccc(C(CC(=O)O)N2C(=O)c3ccccc3C2=O)cc1OC>>CCCCCNC(=O)CC(c1ccc(OC)c(OC)c1)N1C(=O)c2ccccc2C1=O,,CCOC(C)=O,,CCOCC,,val
US20110071150A1,CC1(C)OB(c2ccc3[nH]c(-c4c(F)cccc4Cl)cc3c2)OC1(C)C.CCn1nc(-c2cnccn2)cc1OS(=O)(=O)C(F)(F)F>>CCn1nc(-c2cnccn2)cc1-c1ccc2[nH]c(-c3c(F)cccc3Cl)cc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20040082563A1,CC(=O)O.N=C(NO)c1cccc(C2=C(C(=O)Nc3ccc(N4CCCCC4=O)cc3)CCC2)c1>>CC(=O)O.N=C(N)c1cccc(C2=C(C(=O)Nc3ccc(N4CCCCC4=O)cc3)CCC2)c1,[Ni],CO,,,,val
US20150299121A1,C1CCOC1.COC(=O)CC1CC1>>COC(=O)C(C)C1CC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20100222349A1,CCCCc1cc(O[C@H]2CCN(C(=O)OC(C)(C)C)C2)c2ncccc2c1>>CCCCc1cc(O[C@H]2CCNC2)c2ncccc2c1,,C1COCCO1,,Cl,,val
US07183278B1,COC(=O)c1nc(OC)ccc1O>>COc1ccc(O)c(C(=O)O)n1,,CO,,Cl,[Na+].[OH-],val
US20150232481A1,C=CCCc1ccccc1C=O>>C=CCCc1ccccc1CO,,CO,,[BH4-].[Na+],,val
US20130131050A1,CCOC(=O)/C=C(\N)N(Cc1ccc(OC)cc1OC)Cc1ccc(OC)cc1OC.FC(F)(F)COc1ccc(N=C=S)cc1>>COc1ccc(CN(Cc2ccc(OC)cc2OC)c2cc(=O)n(-c3ccc(OCC(F)(F)F)cc3)c(=S)[nH]2)c(OC)c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US04912117,BrCCc1ccccc1.Cl.O=C(c1ccccc1)C1CCNCC1>>Cl.O=C(c1ccccc1)C1CCN(CCc2ccccc2)CC1,,CCOC(C)=O,Cc1ccccc1,[I-].[K+],,val
US20010027196A1,CSc1nc(N)nc(-c2ccc(C)o2)c1C#N.O=C1CCC(=O)N1Br>>CSc1nc(N)nc(-c2ccc(CBr)o2)c1C#N,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20160145251A1,CC(C)(C)OC(=O)N1CC(COc2ccc(Cl)cc2)CC(F)(F)C1>>FC1(F)CNCC(COc2ccc(Cl)cc2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040102627A1,COC(=O)N[C@@H]1CNCC[C@@H]1C.O=Cc1ccccc1>>COC(=O)N[C@@H]1CN(Cc2ccccc2)CC[C@@H]1C,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090018150A1,COc1ccc(Br)cc1C(=O)COC(C)=O>>COc1ccc(Br)cc1C(=O)CO,,Cl,,,,val
US20130065905A1,CCOC(OCC)c1ccc(-c2c[nH]nn2)nc1.CI>>CCOC(OCC)c1ccc(-c2cnn(C)n2)nc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100120785A1,Cc1c(CN2CCN(c3nccnc3Cl)CC2)cnn1-c1ccccc1.OCc1ccc(B(O)O)cc1>>Cc1c(CN2CCN(c3nccnc3-c3ccc(CO)cc3)CC2)cnn1-c1ccccc1.Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(=O)N(C)C,,O,O=C([O-])[O-].[K+].[K+],val
US20070232583A1,Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3csc(N=CN(C)C)n3)c2)n1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3csc(N)n3)c2)n1,,C1CCOC1,,Cl,[Na+].[OH-],val
US07342027B2,Cc1ccc(S(=O)(=O)CN=C=O)cc1.O=Cc1cc(F)ccc1N1CCC(NC(=O)C2(NC(=O)c3ccco3)CCCCC2)C(=O)C1>>O=C(NC1(C(=O)NC2CCN(c3ccc(F)cc3-c3cocn3)CC2O)CCCCC1)c1ccco1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20040053814A1,CCOC(=O)c1cc2ccccc2n1C.CN>>CNC(=O)c1cc2ccccc2n1C,,CO,,,,val
US20060014746A1,COC(CC1SCCCS1)OC.Cc1c(CCl)nc2ccc(Cl)cn12>>COC(CC1(Cc2nc3ccc(Cl)cn3c2C)SCCCS1)OC,,C1CCOC1,,[Li]CCCC,,val
US20100160303A1,CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(-c4cccc5[nH]ccc45)c23)CC1.O=C(Cl)c1ccc(F)cc1>>CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(-c4cccc5c4ccn5C(=O)c4ccc(F)cc4)c23)CC1,CN(C)c1ccncc1,ClCCl,,,,val
US20060173019A1,COCN(c1cc(Cl)cnc1C(=O)c1ccccc1-c1ncco1)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>O=C(c1ccccc1-c1ncco1)c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1,,C1COCCO1,Cl,O,,val
US20050143422A1,CCOC(=O)c1oc2ccc(Cl)c(OC(C)C)c2c1C>>Cc1c(C(=O)O)oc2ccc(Cl)c(OC(C)C)c12,,C1CCOC1,,[Li+].[OH-],,val
US06093732,NCc1cccc2ccccc12.O=C(NCc1ccc(Cl)cc1)c1cnc2cc(S(=O)(=O)Cl)ccc2c1O>>O=C(NCc1ccc(Cl)cc1)c1cnc2cc(S(=O)(=O)NCc3cccc4ccccc34)ccc2c1O,,c1ccncc1,,CCN(C(C)C)C(C)C,Cl,val
US20090253677A1,O=C1CCC(CO)CC1.[C-]#N.[NH4+]>>N#CC1(N)CCC(CO)CC1,,CO,,[Na+].[OH-],[Cl-].[NH4+],val
US20150322076A1,CC(C)(C#N)CC=O.COC(=O)c1ccc(NC(=O)CN)c(Cl)c1>>COC(=O)c1ccc(NC(=O)C/N=C/CC(C)(C)C#N)c(Cl)c1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US05719278,Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Cl)cn1.c1cnc2c(c1)NCCc1cn[nH]c1-2>>Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCc3cn[nH]c3-c3ccncc32)cn1,,CO,ClCCl,CCN(CC)CC,[Na+].[OH-],val
US20120295884A1,CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccc(O)cc12.CI>>COc1ccc2c(c1)c(C(C)=O)cn2CC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cccc(Cl)c1F,,CS(C)=O,,[K+].[OH-],,val
US06159975,CCOC(CCc1cnc2nccnc2c1)OCC>>O=CCCc1cnc2nccnc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120157434A1,CNc1ccc2c(c1)C[C@H]1[C@H](CNC(C)=O)OC(=O)N21.O=C(Cl)CCl>>CC(=O)NC[C@@H]1OC(=O)N2c3ccc(N(C)C(=O)CCl)cc3C[C@@H]12,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20140256756A1,CC(C)(C)c1nsc(Cl)n1.CS(=O)(=O)c1ccc(N[C@H]2CCCN(C3CCNCC3)C2=O)c(F)c1>>CC(C)(C)c1nsc(N2CCC(N3CCC[C@H](Nc4ccc(S(C)(=O)=O)cc4F)C3=O)CC2)n1,,CCO,,Cl,,val
US20060252818A1,CCCCP(CCCC)CCCC.Oc1cccc2ccccc12>>CCCCP(=O)(CCCC)CCCC,,C1CCOC1,,,,val
US20120264737A1,CCc1cc(-c2cc(C(=O)O)c(C)cc2C2CCC2)n[nH]1.N#Cc1ccc(C2CCNCC2)cc1>>CCc1cc(-c2cc(C(=O)N3CCC(c4ccc(C#N)cc4)CC3)c(C)cc2C2CCC2)n[nH]1,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,CCN=C=NCCCN(C)C,Cl,val
US06077866,CSCc1ccc(C(=O)c2ccc(Cl)cc2)cc1.OO>>CS(=O)Cc1ccc(C(=O)c2ccc(Cl)cc2)cc1,,Cc1ccccc1,,CC(=O)O,O,val
US04532240,CCOC(=O)CC[C@H](NC(=O)c1ccc(N2CCN(c3c(N)nc(N)nc3CC)CC2)cc1)C(=O)OCC>>CCc1nc(N)nc(N)c1N1CCN(c2ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc2)CC1,,CO,,[Na+].[OH-],,val
US20150197509A1,CC(C)(C)OC(=O)CBr.CC(C)N>>CC(C)NCC(=O)OC(C)(C)C,,C1CCOC1,,CCN(CC)CC,,val
US20130252941A1,O=Cc1cnccc1Cl.[N-]=[N+]=[N-]>>[N-]=[N+]=Nc1ccncc1C=O,,CN(C)C=O,,CCOC(C)=O,,val
US20070225267A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@@H]1N[C@@H](COCc2ccccc2)CO[C@H]1OCC(C)(C)C>>C[C@H]1[C@H](OCC(C)(C)C)OC[C@H](COCc2ccccc2)N1C(=O)OC(C)(C)C,,CC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US05985849,CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cc(C(O)(c3ccccc3)c3ccccc3)c(=O)[nH]c2=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C>>CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cc(C(c3ccccc3)c3ccccc3)c(=O)[nH]c2=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US06235789B1,CC(=O)Cl.COc1ccc2c(c1)C(CCN)CC2>>COc1ccc2c(c1)C(CCNC(C)=O)CC2,,ClCCl,,CCN(CC)CC,O,val
US20140275027A1,CNC(=O)c1ccc(Br)cn1.Cc1ccc(S(=O)(=O)n2c(C3=CCN(C(=O)OC(C)(C)C)CC3)cc3c(B4OC(C)(C)C(C)(C)O4)ccnc32)cc1>>CNC(=O)c1ccc(-c2ccnc3c2cc(C2=CCN(C(=O)OC(C)(C)C)CC2)n3S(=O)(=O)c2ccc(C)cc2)cn1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20040048916A1,CC(C)CN.O=C1OC(=O)c2c(F)cccc21>>CC(C)CN1C(=O)c2cccc(F)c2C1=O,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100210667A1,CO.Cc1c(N)[nH]cnc1=O>>COc1ncnc(N)c1C,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020082426A1,CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N1CC(SCc2ccccc2)C(O)(O)C1.O=C(O)C(F)(F)F>>CC(C)C[C@H](N)C(=O)N1CC(O)C(SCc2ccccc2)C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20160052939A1,COC(=O)c1cnc(N[C@@H]2C[C@H]3C[C@@H]2N(C(=O)OC(C)(C)C)C3)cn1>>COC(=O)c1cnc(N[C@@H]2C[C@@H]3CN[C@H]2C3)cn1,,C1COCCO1,CCOC(C)=O,Cl,,val
US05356886,CC(C)OP(=O)(/C=C/CCO[Si](C)(C)C(C)(C)C)OC(C)C>>CC(C)OP(=O)(/C=C/CCO)OC(C)C,,CC(=O)O,O,,,val
US06372736B1,CC(C)(C)OC(=O)N1C[C@H](N=[N+]=[N-])C[C@H]1COCc1ccccc1>>CC(C)(C)OC(=O)N1C[C@H](N)C[C@H]1COCc1ccccc1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080242665A1,Clc1nc(N2CCOCC2)c2sc(CN3CCNCC3)cc2n1.O=S(=O)(Cl)C1CC1>>O=S(=O)(C1CC1)N1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1,,ClCCl,,CCN(CC)CC,,val
US03933811,CNC.O=Cc1ncccn1.[C-]#N>>CN(C)C(C#N)c1ncccn1,,CCOCC,,O,,val
US20120238582A1,CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCC1>>CCOC(=O)C1(c2ccc(N)cc2)CCC1,[Pd],C1CCOC1,,,,val
US20030144263A1,Cc1cn(-c2ccc([N+](=O)[O-])cc2F)cn1>>Cc1cn(-c2ccc(N)cc2F)cn1,[Pd],C1CCOC1,CO,O=C[O-].[NH4+],,val
US20130059835A1,COc1c(C(C)n2nc(Br)c3c(N)ncnc32)cc(Cl)c(C)c1C1CNC1.N#CCBr>>COc1c(C(C)n2nc(Br)c3c(N)ncnc32)cc(Cl)c(C)c1C1CN(CC#N)C1,CN(C)C=O,CC#N,,CCN(CC)CC,,val
US20140128383A1,CCOC(=O)C(=O)c1c(-c2ccccc2)sc2ccccc12>>CCOC(=O)C(O)c1c(-c2ccccc2)sc2ccccc12,,C1CCOC1,CO,[BH4-].[Na+],,val
US04791111,O=[N+]([O-])c1ccc(F)cc1.Oc1ccc(N2CCNCC2)cc1>>O=[N+]([O-])c1ccc(N2CCN(c3ccc(O)cc3)CC2)cc1,,O,,CC(=O)N(C)C,O=C([O-])[O-].[K+].[K+],val
US20070259849A1,C1COCCN1.CCOC(=O)c1cnc(SC)nc1NC1CC1>>CCOC(=O)c1cnc(N2CCOCC2)nc1NC1CC1,,ClCCl,,O=C(OO)c1cccc(Cl)c1,,val
US20140155415A1,OC1COc2ccc(Br)cc2OC1>>O=C1COc2ccc(Br)cc2OC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20070244155A1,CCOC(=O)CCN1C(=O)CCc2cc(OCc3ccc(OC)cc3)ccc21>>CCOC(=O)CCN1C(=O)CCc2cc(O)ccc21,[Pd],CCO,,[H][H],,val
US20130252962A1,CCCCCCN.CN1C(=O)C2(COc3cc4c(cc32)OCCO4)c2c(N)cccc21.O=C(Cl)OC(Cl)(Cl)Cl>>CCCCCCNC(=O)Nc1cccc2c1C1(COc3cc4c(cc31)OCCO4)C(=O)N2C,,C1COCCO1,,CCN(CC)CC,,val
US05047540,BrC(Br)(Br)Br.OCC1COC(c2ccccc2)OC1>>BrCC1COC(c2ccccc2)OC1,,c1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20110300165A1,CC(C)(C)OC(=O)C1CN(Cc2ccc(C(N)=NO)cc2)C1.CC(C)Cc1onc(C(=O)F)c1C(F)(F)F>>CC(C)Cc1onc(-c2nc(-c3ccc(CN4CC(C(=O)OC(C)(C)C)C4)cc3)no2)c1C(F)(F)F,,CC#N,ClCCl,CCN(C(C)C)C(C)C,,val
US04866091,CC(=NOCC(=O)OC(C)(C)C)c1ccc(NS(C)(=O)=O)c(Oc2ccc(F)cc2F)c1>>CC(=NOCC(=O)O)c1ccc(NS(C)(=O)=O)c(Oc2ccc(F)cc2F)c1,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20060223797A1,C#CCCCN1CCN(C(=O)Oc2ccc([N+](=O)[O-])cc2)CC1.CN>>C#CCCCN1CCN(C(=O)NC)CC1,,C1CCOC1,,,,val
US20110311459A1,ClCc1noc(-c2nccs2)n1.O=C(O[C@H]1CN2CCC1CC2)C(Nc1cccc(F)c1)c1ccccc1>>O=C(O[C@H]1C[N+]2(Cc3noc(-c4nccs4)n3)CCC1CC2)C(Nc1cccc(F)c1)c1ccccc1.[Cl-],,CCOC(C)=O,,,,val
US20140024636A1,CC(CO)CO.COC(=O)NS(=O)(=O)Nc1c(Cl)cc(C(F)(F)F)cc1Cl>>COC(=O)N1CC(C)CN(c2c(Cl)cc(C(F)(F)F)cc2Cl)S1(=O)=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150141406A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCNCCCl.Nc1ccc(Br)cc1>>CC(C)(C)OC(=O)N1CCN(c2ccc(Br)cc2)CC1,,O,OCCO,CCN(CC)CC,Cl,val
US20150246042A1,COc1cc(NC(=O)Oc2ccccc2)cc(C(F)(F)F)c1.COc1cc2ncnc(Sc3cccc(N)c3)c2cc1OC>>COc1cc(NC(N)=O)cc(C(F)(F)F)c1,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20060030613A1,CC(C)(C)c1ccc(C=O)cc1.NCCc1c(Cl)cccc1Cl>>CC(C)(C)c1ccc(CNCCc2c(Cl)cccc2Cl)cc1,Cl,CO,,[BH4-].[Na+],,val
US06187933B1,COC(=O)c1ccc2c(c1)C(OS(=O)(=O)C(F)(F)F)=CCC2(C)C.c1ccsc1>>COC(=O)c1ccc2c(c1)C(c1cccs1)=CCC2(C)C,,C1CCOC1,,[Li]CCCC,,val
US20120316147A1,NC(=O)C(N)C1CC1.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1>>NC(=O)C(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1,,CCCCCCC,,CO,,val
US20140336232A1,CC(=O)c1ccc(F)cc1F.CCOP(=O)(Cc1ccccc1Cl)OCC>>CC(=Cc1ccccc1Cl)c1ccc(F)cc1F,,CN(C)C=O,O,[H-].[Na+],,val
US20070155714A1,CC(=O)NC[C@H]1CN(c2ccc(OCC3(OC(=O)CCC(=O)OCc4ccccc4)CCNCC3)c(F)c2)C(=O)O1.O=C(O)c1cn(C2CC2)c2nc(Cl)c(F)cc2c1=O>>CC(=O)NC[C@H]1CN(c2ccc(OCC3(OC(=O)CCC(=O)OCc4ccccc4)CCN(c4nc5c(cc4F)c(=O)c(C(=O)O)cn5C4CC4)CC3)c(F)c2)C(=O)O1,,CN1CCCC1=O,,CCN(CC)CC,C[Si](C)(C)Cl,val
US20110077237A1,Nc1ncccc1C(=O)c1cccc(Br)n1.O=C1CCC(=O)N1Br>>Nc1ncc(Br)cc1C(=O)c1cccc(Br)n1,,CC#N,,,,val
US20100210647A1,CC(C)(C)OC(=O)N1CCN(CC[C@@H]2CSC(c3cc4cc(Cl)cc(NC5CCCC5)c4[nH]3)=N2)CC1>>Clc1cc(NC2CCCC2)c2[nH]c(C3=N[C@H](CCN4CCNCC4)CS3)cc2c1,,ClCCl,,CCOC(C)=O,Cl,val
US20070099941A1,Brc1cncnc1.CCCC[Sn](Cl)(CCCC)CCCC>>CCCC[Sn](CCCC)(CCCC)c1cncnc1,,C1CCOC1,,[Li]CCCC,,val
US20160024103A1,C/C=C/c1nc2oc(-c3ccc(F)cc3)c(C(=O)NC)c2cc1-c1ccc(F)c(C(=O)NC23CC(C2)C3)c1>>CCCc1nc2oc(-c3ccc(F)cc3)c(C(=O)NC)c2cc1-c1ccc(F)c(C(=O)NC23CC(C2)C3)c1,[Pd],CO,,N#N,,val
US20110172240A1,CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)NCCNC(=O)/C=C/C(=O)OC>>CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)NCCNC(=O)/C=C/C(=O)O,,C1CCOC1,,[Na+].[OH-],,val
US20110245224A1,C[C@@H]1CN2c3c(cc(C(=O)c4ccccc4)c(F)c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1.NO>>C[C@@H]1CN2c3c(cc(/C(=N/O)c4ccccc4)c(F)c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1,,CO,c1ccncc1,Cl,,val
US20120071461A1,CNC1CCN(C(=O)OC(C)(C)C)CC1.O=Cc1ccccc1>>CN(Cc1ccccc1)C1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20060063828A1,COC(=O)c1ccc(CC(=O)c2c(OC)ccc(-c3cccs3)c2OC)cc1>>COc1ccc(-c2cccs2)c(OC)c1C(=O)Cc1ccc(C(=O)O)cc1,,C1CCOC1,O,CC(C)(C)[O-].[K+],,val
US20090105212A1,CCCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(OCCCCN4CCC(C(=O)OC)CC4)cc3)c2n1>>CCCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(OCCCCN4CCC(C(=O)O)CC4)cc3)c2n1,,[Na+],[OH-],Cl,,val
US05232940,CCOC=Nc1c(C#N)c(C(F)(F)F)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl>>CNc1c(C#N)c(C(F)(F)F)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl,,CO,,[BH4-].[Na+],,val
US05273990,COC(=O)[C@@](N)(Cc1ccc(-c2ccccc2OC)cc1)C(=O)OC(C)(C)C>>COc1ccccc1-c1ccc(C[C@](N)(C(=O)O)C(=O)OC(C)(C)C)cc1,,O,,CCOCC,[Na+].[OH-],val
US20110092671A1,CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(N)=O>>CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O,,CO,,,,val
US20120059161A1,C=CCCCCOc1cc(OC)ccc1S(=O)(=O)O.O=S(Cl)Cl>>C=CCCCCOc1cc(OC)ccc1S(=O)(=O)Cl,,c1ccncc1,,,,val
USH0001992H1,CC(C)[C@@H](N)C(=O)OC(C)(C)C.O=S(=O)(Cl)c1ccc(Oc2ccc(Br)cc2)cc1>>CC(C)[C@@H](NS(=O)(=O)c1ccc(Oc2ccc(Br)cc2)cc1)C(=O)OC(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05006530,CCOC(=O)c1c(C(C)C)nc(C(C)C)c(CCl)c1-c1ccc(F)cc1.[O-]c1ccccc1>>CCOC(=O)c1c(C(C)C)nc(C(C)C)c(COc2ccccc2)c1-c1ccc(F)cc1,,C1CCOC1,,O,,val
US20050250769A1,COC(=O)C(CC(=O)c1ccccc1OC(F)(F)F)C(C)=O.NC[C@@H]1CCCO1>>COC(=O)c1cc(-c2ccccc2OC(F)(F)F)n(C[C@@H]2CCCO2)c1C,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080019915A1,CC(=O)Nc1cccc(Br)n1.O=[N+]([O-])O>>Nc1ccc([N+](=O)[O-])c(Br)n1,,O=S(=O)(O)O,,,,val
US06043254,O=[N+]([O-])c1ccc(/C=C/c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1>>O=[N+]([O-])c1ccc(/C=C/c2c[nH]cn2)cc1,,Cl,,CO,ClCCl,val
US20090247517A1,CCOC(=O)c1noc(-c2ccccc2)c1[N+](=O)[O-]>>CCOC(=O)c1noc(-c2ccccc2)c1N,[Ni],CCO,,,,val
US20110034450A1,COC(=O)C1(C)Cc2cccc(O)c2C1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)C1(C)Cc2cccc(OS(=O)(=O)C(F)(F)F)c2C1,,c1ccncc1,,O,,val
US20100152183A1,CN(C)CCOc1cccc(-c2ccc(Cl)cc2)c1CN1CCN(C(=O)OC(C)(C)C)CC1.O=C(O)C(F)(F)F>>CN(C)CCOc1cccc(-c2ccc(Cl)cc2)c1CN1CCNCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20120196864A1,CNC1=NC(=O)S/C1=C\c1ccc(OCc2ccc(C(F)(F)F)cc2C(F)(F)F)c(C(=O)OC)c1>>CNC1=NC(=O)S/C1=C\c1ccc(OCc2ccc(C(F)(F)F)cc2C(F)(F)F)c(C(=O)O)c1,,CO,,[Na+].[OH-],,val
US20130336965A1,C[C@H]1CC(c2ccncc2[N+](=O)[O-])=C[C@@H](NC(=O)OC(C)(C)C)[C@H]1OCCS(C)(=O)=O>>C[C@H]1C[C@@H](c2ccncc2N)C[C@@H](NC(=O)OC(C)(C)C)[C@H]1OCCS(C)(=O)=O,[Pd],CCO,,,,val
US20110183985A1,CC(=O)c1cc(Cl)c2cccnc2c1N1CCNCC1.CN(C)C(=O)CCl>>CC(=O)c1cc(Cl)c2cccnc2c1N1CCN(CC(=O)N(C)C)CC1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20020103247A1,CC(C)(C)OC(=O)n1ccc2cc(C#CCCCO)ccc21>>CC(C)(C)OC(=O)n1ccc2cc(CCCCCO)ccc21,[Pd],CO,,,,val
US20060270706A1,COC(=O)Cn1ncnc1/C=C1\CN(C(C(=O)C2CC2)c2ccccc2F)CCC1SC(C)=O.Cl>>COC(=O)Cn1ncnc1/C=C1\CN(C(C(=O)C2CC2)c2ccccc2F)CCC1S.Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20020115674A1,CCOC(=O)c1cc(F)c(Cl)cc1NC1CC1>>O=C(O)c1cc(F)c(Cl)cc1NC1CC1,,C1CCOC1,,CO,[Li+].[OH-],val
US20040014962A1,CC(C)(C)[Si](OC1CN(c2nc(C(=O)N3CCOCC3)cs2)C1)(c1ccccc1)c1ccccc1>>O=C(c1csc(N2CC(O)C2)n1)N1CCOCC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04178449,CN(C)C=CC(=O)c1cccc(C(F)(F)F)c1.NC(=O)c1[nH]cnc1N>>NC(=O)c1ncn2c(-c3cccc(C(F)(F)F)c3)ccnc12,,CC(=O)O,,Cl,CC(=O)[O-].[Na+],val
US20130317024A1,CCOC(=O)c1ccn(C(C)C)c1C(Nc1cccc(Cl)c1F)c1ccc(Cl)cc1C>>Cc1cc(Cl)ccc1C(Nc1cccc(Cl)c1F)c1c(C(=O)O)ccn1C(C)C,,C1COCCO1,,[Li+].[OH-],,val
US20130059832A1,CCCC[Sn](C=COCC)(CCCC)CCCC.CCOC(=O)c1cnc2ccc(Br)cn12>>CCO/C=C/c1ccc2ncc(C(=O)OCC)n2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20050227987A1,NCCc1cccs1.O=C(Cl)c1cc(Cl)cc(Cl)c1>>O=C(NCCc1cccs1)c1cc(Cl)cc(Cl)c1,,C1CCOC1,,CCN(CC)CC,,val
US20130053409A1,CNCCN(C)C.COc1cc(F)c([N+](=O)[O-])cc1Nc1ncc(C)c(-c2cn(C)c3ccccc23)n1>>COc1cc(N(C)CCN(C)C)c([N+](=O)[O-])cc1Nc1ncc(C)c(-c2cn(C)c3ccccc23)n1,,CC(=O)N(C)C,,,,val
US04358409,CC(=O)[C@H]1[C@H](C=O)C1(C)C.CCOP(=O)(OCC)C(Cl)c1ccc(Cl)cc1>>CC(=O)[C@H]1[C@H](C=C(Cl)c2ccc(Cl)cc2)C1(C)C,,C1CCOC1,CO,O,C[O-].[Na+],val
US20140200231A1,C[Si](C)(C)N=[N+]=[N-].N#CCCCCC(=O)N1Cc2cnc(NC3Cc4ccccc4C3)nc2C1>>O=C(CCCCc1nnn[nH]1)N1Cc2cnc(NC3Cc4ccccc4C3)nc2C1,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US05750525,CCOP(=O)(Cn1c(=O)c(=O)[nH]c2cc(-n3ccnc3)c([N+](=O)[O-])cc21)OCC>>O=c1[nH]c2cc(-n3ccnc3)c([N+](=O)[O-])cc2n(CP(=O)(O)O)c1=O,,Cl,,,,val
US20150344466A1,CCOC(=O)c1cc(C(C)OCc2ccccc2)on1>>CC(OCc1ccccc1)c1cc(C(=O)O)no1,,O,,CCO,[K+].[OH-],val
US20140243373A1,COC(=O)c1ccc([C@H](C)NC(=O)[C@H]2CCCCN2)cc1.O=Cc1cccc(OC(F)(F)F)c1>>COC(=O)c1ccc([C@H](C)NC(=O)[C@H]2CCCCN2Cc2cccc(OC(F)(F)F)c2)cc1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20030166719A1,COCCl.O=[N+]([O-])c1ccc(CCO)c(Cl)c1>>COCOCCc1ccc(N)cc1Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06143764,COc1cc2nccc(Cl)c2cc1OC.N#Cc1ccc(C(=O)c2ccc(O)cc2)cc1>>COc1cc2nccc(Oc3ccc(C(=O)c4ccc(C#N)cc4)cc3)c2cc1OC,CN(C)c1ccncc1,CCCCCC,CCOC(C)=O,Cc1ccccc1C,,val
US20100189773A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1ccc(S(=O)(=O)n2cc(Br)c3cc(NC(=O)OCc4ccccc4)cnc32)cc1>>Cc1ccc(S(=O)(=O)n2cc(B3OC(C)(C)C(C)(C)O3)c3cc(NC(=O)OCc4ccccc4)cnc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,CC(=O)[O-].[K+],,val
US20110166161A1,COc1nc(N[C@@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)ccc1C#N.O=C1CCC(=O)N1Cl>>COc1nc(N[C@@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)c(Cl)cc1C#N,,CC(C)O,,,,val
US20100216814A1,CC(=CBr)c1ccccc1F.CN1CCc2[nH]c3ccc(Cl)cc3c2C1>>C/C(=C\n1c2c(c3cc(Cl)ccc31)CN(C)CC2)c1ccccc1F,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20110144164A1,CCC=O.COC(=O)c1c(C)cc(=O)n(N)c1C>>CCCNn1c(C)c(C(=O)OC)c(C)cc1=O,,CO,,[BH4-].[Na+],,val
US20120184531A1,CCOC(=O)C1c2c(oc3c(Cl)cc(S(=O)(=O)c4ccccc4)cc23)CCN1Cc1ccc(OC)cc1>>COc1ccc(CN2CCc3oc4c(Cl)cc(S(=O)(=O)c5ccccc5)cc4c3C2CO)cc1,,CCO,,O,[BH4-].[Li+],val
US20100286147A1,C=Cc1ccccc1-c1ccccc1.O=C(CCl)C(Cl)=NO>>O=C(CCl)C1=NOC(c2ccccc2-c2ccccc2)C1,,CC#N,,O=C([O-])O.[Na+],,val
US20040266826A1,COC(=O)Cl.C[Si](C)(C)CCOC(=O)C[C@]1(c2ccc(-c3ccc(-c4ccc(N)cc4)cc3)s2)CCCCS1(=O)=O>>COC(=O)Nc1ccc(-c2ccc(-c3ccc([C@@]4(CC(=O)OCC[Si](C)(C)C)CCCCS4(=O)=O)s3)cc2)cc1,,ClC(Cl)Cl,c1ccncc1,,,val
US05616579,COC(=O)CSCCCCC(=O)NC/C=C\COc1cc(CN2CCCCC2)ccn1>>O=C(CCCCSCCO)NC/C=C\COc1cc(CN2CCCCC2)ccn1,,C1CCOC1,,CO,[BH4-].[Na+],val
US20130040931A1,Cc1cccc(I)c1Br.OC1CCOC1>>Cc1cccc(OC2CCOC2)c1Br,[Cu]I,CCOC(C)=O,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US20020031834A1,CCOC(=O)c1ccc2cc(Cl)ccn2c1=O.O=[N+]([O-])c1cccc(O)c1>>CCOC(=O)c1ccc2cc(Oc3cccc([N+](=O)[O-])c3)ccn2c1=O,,CCOC(C)=O,O,CN(C)C=O,[H-].[Na+],val
US05013863,CC(C)(C)OC(=O)NCC(C=O)c1ccc(Cl)cc1.CCO[PH](C)=O>>CCOP(C)(=O)C(O)C(CNC(=O)OC(C)(C)C)c1ccc(Cl)cc1,,CCN(CC)CC,,,,val
US06821980B1,CC(=O)OCc1c2ccccc2c(COC(C)=O)c2ccccc12.CCOc1cc(Cc2cnc(N)nc2N)cc(OS(=O)(=O)C(C)C)c1-c1ccc(O)cc1>>CCOc1cc(Cc2cnc(N)nc2N)cc(OS(=O)(=O)C(C)C)c1-c1ccc(OC(C)=O)cc1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20060293341A1,CC(C)S(=O)(=O)NC[C@@H]1CC[C@@H](NC(=O)OCc2ccccc2)CC1>>CC(C)S(=O)(=O)NC[C@@H]1CC[C@@H](N)CC1,[Pd],CCO,,,,val
US06114358,N#C[Cu].O=Cc1cc(Br)cs1>>N#Cc1csc(C=O)c1,,CN(C)C=O,,,,val
US06017560,Cc1c([N+](=O)[O-])cc[n+]([O-])c1C.OCC(F)(F)C(F)(F)F>>Cc1c(OCC(F)(F)C(F)(F)F)cc[n+]([O-])c1C,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140140955A1,COc1nc(N)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@]1(C)O.O=C1CCC(=O)N1Cl>>COc1nc(N)nc2c1nc(Cl)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@@]1(C)O,,C1CCOC1,,,,val
US05536701,CCOc1cnnc(Oc2cc(C(F)(F)F)nn2C)c1.CN(C)C=O.Cn1nc(C(F)(F)F)cc1Oc1cc(O)cnn1>>Cn1nc(C(F)(F)F)cc1Oc1cc(OC(F)F)cnn1,,CN(C)C=O,,[H-].[Na+],,val
US20090137609A1,CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3ccc(OC)c(CC(=O)OC)c3)c(C)c2)cc1C)CC>>CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3ccc(OC)c(CC(=O)O)c3)c(C)c2)cc1C)CC,,C1CCOC1,CO,[Na+].[OH-],[Cl-].[NH4+],val
US05455246,O=C(N1CCC(O)CC1)C12CC(c3ccccc31)c1ccc(Cl)cc12>>OC1CCN(CC23CC(c4ccccc42)c2ccc(Cl)cc23)CC1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100022589A1,CS(=O)(=O)OCCc1ccccn1.O=C(NC1CCCCC1)c1cccnc1S>>O=C(NC1CCCCC1)c1cccnc1SCCc1ccccn1,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20030232853A1,CCOC(OCC)c1cc2ccc(C(=O)OC)cc2o1>>COC(=O)c1ccc2cc(C=O)oc2c1,,O,,O=CO,,val
US20070129358A1,OCC(O)(CC1=CCSc2ccccc21)C(F)(F)F>>OCC(O)(CC1CCSc2ccccc21)C(F)(F)F,[Ni],CCO,,[H][H],,val
US20070010556A1,COC(=O)c1sc(-c2ccccc2)cc1N.O=C=NC(=O)C(Cl)(Cl)Cl>>COC(=O)c1sc(-c2ccccc2)cc1NC(=O)NC(=O)C(Cl)(Cl)Cl,,C1CCOC1,,,,val
US20080171772A1,CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(C=O)cc2n1Cc1ccccc1.NCCN>>CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(C3=NCCN3)cc2n1Cc1ccccc1,,ClCCl,,O=C1CCC(=O)N1Br,,val
US04499102,C[C@H](S)C(=O)N1CCC[C@H]1C(=O)O.O=C(O)C(Br)CCc1ccccc1>>C[C@H](SC(CCc1ccccc1)C(=O)O)C(=O)N1CCC[C@H]1C(=O)O,,O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20080058340A1,O=Cc1cc(F)c(F)c(F)c1>>OCc1cc(F)c(F)c(F)c1,,C1CCOC1,,O,[BH4-].[Na+],val
US20110059043A1,CI.Oc1cc(Cl)cc(Cl)c1I>>COc1cc(Cl)cc(Cl)c1I,,CN(C)C=O,,,,val
US05185340,BrCc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.CCCc1c(O)nc(C(F)(F)F)nc1CC>>CCCc1c(CC)nc(C(F)(F)F)nc1OCc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,CN(C)C=O,,[Na],C[O-].[Na+],val
US05702637,CCCCCCCCc1cnc(-c2ccc(OC[C@H](O)COCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc2)nc1.CI>>CCCCCCCCc1cnc(-c2ccc(OC[C@@H](COCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)OC)cc2)nc1,,CN(C)C=O,O,[H-].[Na+],,val
US20060160794A1,CN(C(=O)c1nnn(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1N1CCNCC1)c1ccccc1Cl.CS(=O)(=O)Cl>>CN(C(=O)c1nnn(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1N1CCN(S(C)(=O)=O)CC1)c1ccccc1Cl,CN(C)c1ccncc1,ClCCl,,O,,val
US20080255124A1,C[Si](C)(C)N=C=O.N#Cc1ccc(N(CCOc2ccc(N)cc2)CC(F)(F)F)cc1C(F)(F)F>>N#Cc1ccc(N(CCOc2ccc(NC(N)=O)cc2)CC(F)(F)F)cc1C(F)(F)F,CN(C)c1ccncc1,ClCCl,,,,val
US20110178089A1,COc1cc(F)c(F)cc1N.O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21>>COc1cc(F)c(F)cc1NC(=O)c1cnccc1Oc1cc(Cl)ccc1Cl,,CCCCCCC,CCOC(C)=O,,,val
US20040122001A1,COc1ccc2ccc(OS(=O)(=O)C(F)(F)F)cc2c1>>O=S(=O)(Oc1ccc2ccc(O)cc2c1)C(F)(F)F,,ClCCl,,BrB(Br)Br,,val
US20150166523A1,BrCCOC1CCCCO1.Cc1ccc(-n2nccn2)c(C(=O)N[C@@H](C)Cn2cc(-c3ccc(F)cn3)cn2)c1>>Cc1ccc(-n2nccn2)c(C(=O)N(CCO)[C@@H](C)Cn2cc(-c3ccc(F)cn3)cn2)c1,,CN(C)C=O,,O,[H-].[Na+],val
US20050234236A1,Cc1cc(CC(=O)OC(C)(C)C)n[nH]c1=O.N#Cc1cc(C#N)cc(Oc2c([N+](=O)[O-])ccc(F)c2F)c1>>Cc1cc(C(C(=O)OC(C)(C)C)c2ccc([N+](=O)[O-])c(Oc3cc(C#N)cc(C#N)c3)c2F)n[nH]c1=O,,C1CCOC1,CN1CCCC1=O,O,CC(C)(C)[O-].[K+],val
US20080255358A1,CCc1ccccc1CBr.Cc1nc2c(O)cc(-n3ccccc3=O)cn2c1C>>CCc1ccccc1COc1cc(-n2ccccc2=O)cn2c(C)c(C)nc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060281804A1,C[Si](C)(C)N=C=O.NC1CCCc2c1[nH]c1ccc(Br)cc21>>NC(=O)NC1CCCc2c1[nH]c1ccc(Br)cc21,,CC(C)O,,,,val
US20080227784A1,O=[N+]([O-])c1ccc(N2CCC(CN=Cc3ccccc3)CC2)c(F)c1>>NCC1CCN(c2ccc([N+](=O)[O-])cc2F)CC1,,Cl,,,,val
US20130310380A1,Cc1cc(-c2cnc(N3CCCC(C)C3)nc2-c2ccoc2C)ccn1.Cl>>Cc1cc(-c2cnc(N3CCCC(C)C3)nc2-c2ccoc2C)ccn1.Cl,,ClCCl,,,,val
US03974154,CC(C)(C)OC(=O)C1=C(Cc2ccc(F)cc2)CS[C@@H]2C(NC(c3ccccc3)(c3ccccc3)c3ccccc3)C(=O)N12>>CC(C)(C)OC(=O)C1=C(Cc2ccc(F)cc2)CS[C@@H]2C(N)C(=O)N12,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20020099212A1,Cc1ccc(CO)cc1Cl>>Cc1ccc(C=O)cc1Cl,,CS(C)=O,,CCN(CC)CC,,val
US20150152112A1,CC(C)(C)OC(=O)c1cn(-c2ccc(Cl)cc2Br)nn1.CCOC(=O)[C@@H]1CCc2cc(B3OC(C)(C)C(C)(C)O3)cc(=O)n21>>CCOC(=O)[C@@H]1CCc2cc(-c3cc(Cl)ccc3-n3cc(C(=O)OC(C)(C)C)nn3)cc(=O)n21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20060229286A1,CCOC=C(C(=O)OCC)C(=O)C(F)(F)F.Cc1cc(N)n[nH]1>>Cc1cc2ncc(C(=O)O)c(C(F)(F)F)n2n1,Cl,CCO,,,,val
US03953595,ClCc1ccccc1.O=C(O)c1cc(O)cc(C(F)(F)F)c1>>O=C(O)c1cc(OCc2ccccc2)cc(C(F)(F)F)c1,,CS(C)=O,,[H-].[Na+],,val
US20130338140A1,CC(C)(C)OC(=O)N[C@H](CCO)c1ccc(Cl)c(Cl)c1.CI>>COCC[C@@H](NC(=O)OC(C)(C)C)c1ccc(Cl)c(Cl)c1,,O,,C1CCOC1,[H-].[Na+],val
US20100286145A1,CC(C)c1cc(CNC[C@@H](O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)cc(OCc2ccccc2)c1>>CC(C)c1cc(O)cc(CNC[C@@H](O)[C@@H](N)Cc2ccccc2)c1,[Pd],CO,Cl,,,val
US20120165318A1,COC(=O)c1ccc2nc(-c3ccc4c(c3)OCO4)c(N(C)C(C)C)nc2c1>>CC(C)N(C)c1nc2cc(C(=O)O)ccc2nc1-c1ccc2c(c1)OCO2,,O,,CO,[Na+].[OH-],val
US20090326066A1,CCOC(=O)/C(C)=C/[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)OC(C)(C)C>>C/C(=C\[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)O,,CCO,,[Li+].[OH-],,val
US20120010189A1,COc1c(C=O)ccc(OC2CCCCO2)c1C>>COc1c(C=O)ccc(O)c1C,,CCO,,Cl,,val
US20160251339A1,C=O.COc1ccc(S(=O)(=O)n2cc(C(F)F)c3ccc(Cl)cc32)cc1N1CCNCC1>>COc1ccc(S(=O)(=O)n2cc(C(F)F)c3ccc(Cl)cc32)cc1N1CCN(C)CC1,,CO,,[BH3-]C#N.[Na+],,val
US20150353533A1,COC(=O)c1ccc2c(c1)N(C)C(=O)[C@@H](NC(=O)c1cc(Cc3ccccc3)on1)CO2>>CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)COc2ccc(C(=O)O)cc21,,C1CCOC1,O,[Li+].[OH-],,val
US20020115669A1,CCOC(=O)C(=O)C(F)C(=O)OCC.O=Cc1ccc(Br)cc1>>CCOC(=O)/C(F)=C/c1ccc(Br)cc1,,C1CCOC1,,,,val
US05240938,BrC(Br)(Br)Br.CCOc1cc(CO)ccc1Oc1ccccc1CC(=O)OC>>CCOc1cc(CBr)ccc1Oc1ccccc1CC(=O)OC,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05276035,Fc1ccc(C(OCCN2CCNCC2)c2ccc(F)cc2)cc1.O=C(CCCCl)c1cccs1>>O=C(CCCN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1cccs1,,CC(=O)CC(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20110105436A1,CN1CCNCC1.Cc1cccc(Nc2nc(-c3ccnc(Br)c3)cs2)c1>>Cc1cccc(Nc2nc(-c3ccnc(N4CCN(C)CC4)c3)cs2)c1,,O,,,,val
US20080176857A1,CCCC#CC(=O)O.CCc1cc2c(N3CCNCC3)nc(SCC(=O)OC)nc2s1>>C#CCCCC(=O)N1CCN(c2nc(SCC(=O)OC)nc3sc(CC)cc23)CC1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,Cl,val
US04849422,O=C(O)c1cccnc1Cl.OCCCN1CCNCC1>>O=C(O)c1cccnc1N1CCN(CCCO)CC1,,C1COCCO1,,,,val
US05356886,CC(C)OP(=O)(/C=C/CCOn1cnc2c(N)ncnc21)OC(C)C>>Nc1ncnc2c1ncn2OCC/C=C/P(=O)(O)O,,ClCCl,,C[Si](C)(C)Br,,val
US06346622B1,CC1(C)NS(=O)(=O)c2ccccc21.ClCCCBr>>CC1(C)c2ccccc2S(=O)(=O)N1CCCCl,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US04855310,CCOC(=O)CBr.Sc1nnc(S)s1>>CCOC(=O)CSc1nnc(S)s1,,[Na+],[OH-],CO,O,val
US20140243336A1,CC(C)(C)OC(=O)NC1(CO)CC1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCC2(NC(=O)OC(C)(C)C)CC2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US04684639,O=C(O)CN(C(=O)OCc1ccccc1)c1ccc(O)c(O)c1.O=S(=O)(Cl)Cl>>O=C(O)CN(C(=O)OCc1ccccc1)c1cc(O)c(O)cc1Cl,,CC(=O)O,CCOC(C)=O,,,val
US20160016948A1,O=[N+]([O-])c1cnc(Cl)cc1NC1CCCC1>>Nc1cnc(Cl)cc1NC1CCCC1,[Fe],CCO,ClCCl,O,[Cl-].[NH4+],val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(CC(O[Si](C)(C)C(C)(C)C)C(C)(C)C)c2nc(C)nn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(CC(O)C(C)(C)C)c2nc(C)nn12,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20050131042A1,CC(=O)c1cccc(CN2CCN([C@H](C(=O)N[C@@H](Cc3ccccc3)[C@H](O)CN(CC(C)C)S(=O)(=O)c3ccc(/C=N/O)cc3)C(C)(C)C)C2=O)n1>>CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCN(Cc2cccc(C(C)O)n2)C1=O)C(C)(C)C)S(=O)(=O)c1ccc(/C=N/O)cc1,,CO,,[BH4-].[Na+],,val
US20050256153A1,CC1CCN(CCCNC(=O)c2c(O)c3ccsc3n(C(C)C)c2=O)CC1.CI>>COc1c(C(=O)NCCCN2CCCCC2)c(=O)n(C(C)C)c2sccc12,,C1CCOC1,,[Li]CCCC,,val
US20050277671A1,CC(C)(C)OC(=O)C1(C#N)CCOCC1>>CC(C)(C)OC(=O)C1(CN)CCOCC1,[Ni],CO,,,,val
US20140088121A1,CC(C)(C)S(=O)(=O)NCCBr.Nc1ncnc2[nH]c(Sc3cc4c(cc3I)OCO4)nc12>>CC(C)(C)S(=O)(=O)NCCn1c(Sc2cc3c(cc2I)OCO3)nc2c(N)ncnc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130331378A1,COC(=O)c1cc(Cc2c(-c3ccccc3)nn3cc(OC)ccc23)ccc1C>>COc1ccc2c(Cc3ccc(C)c(C(=O)O)c3)c(-c3ccccc3)nn2c1,,CO,,Cl,[K+].[OH-],val
US20110034450A1,CCOC(=O)CCc1cccc(NC(=O)C(c2ccc(CN3N=C(c4ccccc4)OCC3=O)cc2)C(C)CC)c1>>CCC(C)C(C(=O)Nc1cccc(CCC(=O)O)c1)c1ccc(CN2N=C(c3ccccc3)OCC2=O)cc1,,C1CCOC1,,[Na+].[OH-],,val
US20090192190A1,COC(=O)c1c(C)c(C#N)cc(C(C)(C)C)c1OC.NO>>COC(=O)c1c(C)c(C(=N)NO)cc(C(C)(C)C)c1OC,,CCO,,Cl,O=C([O-])O.[Na+],val
US20130217680A1,CSc1c(CCN2CCN(C(=O)OC(C)(C)C)CC2)ccc2c1COC2=O.Cl>>CSc1c(CCN2CC[NH2+]CC2)ccc2c1COC2=O.[Cl-],,C1COCCO1,,,,val
US08431695B2,CCOC1(O[Si](C)(C)C)CC1.Nc1ncnn2c(C3CCNCC3)cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c12>>Nc1ncnn2c(C3CCN(C4CC4)CC3)cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c12,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20160145240A1,CCN1CCN(c2ccc(N)cc2)CC1.COc1cc(OC)c(Cl)c(Nc2nc3ccccc3n2-c2cc(Cl)ncn2)c1Cl>>CCN1CCN(c2ccc(Nc3cc(-n4c(Nc5c(Cl)c(OC)cc(OC)c5Cl)nc5ccccc54)ncn3)cc2)CC1,,C1COCCO1,CS(C)=O,O=C(O)C(F)(F)F,,val
US06204293B1,COC(=O)c1ccc(CBr)cc1-c1ccccc1C.OCc1cccs1>>COC(=O)c1ccc(COCc2cccs2)cc1-c1ccccc1C,,CN(C)C=O,,[H-].[Na+],,val
US20040097485A1,COc1ccc(CNc2ncc(C#N)c3sc(I)cc23)cc1.c1c[nH]cn1>>COc1ccc(CNc2ncc(C#N)c3sc(-n4ccnc4)cc23)cc1,[Cu]I,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05591762,CCCCc1nc2c(C)cc(NC(=O)C(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCCc1nc2c(C)cc(NC(=O)C(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06200963B1,COc1cc(OC)cc(C(=O)Cl)c1.COc1ccc(N=Nc2c(S(=O)(=O)OC(C)C)cc3cc(N)ccc3c2O)cc1>>COc1ccc(N=Nc2c(S(=O)(=O)OC(C)C)cc3cc(NC(=O)c4cc(OC)cc(OC)c4)ccc3c2O)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130331404A1,CC(C)(C)OC(=O)N1[C@@H](c2c[nH]c3c(N)ncnc23)[C@H](O)[C@H](O)[C@H]1CO>>Nc1ncnc2c([C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)c[nH]c12,,O,,C,,val
US20130190314A1,Cc1cc(C(=O)CBr)c(C)s1.Nc1ccc(N2CCN(C=O)CC2)nn1>>Cc1cc(-c2cn3nc(N4CCN(C=O)CC4)ccc3n2)c(C)s1,,CC(C)(C)O,O,CCN(CC)CC,,val
US20090062274A1,C/C(=N\C(N)=S)N(C)C.CI>>CSC(N)/N=C(\C)N(C)C.I,,C1CCOC1,,,,val
US20120302540A1,CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](COCc1ccccc1)C(=O)O.CN1C(=O)C2(CCCNC2)C1c1ccccc1>>CN1C(=O)C2(CCCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)NC(=O)OC(C)(C)C)C2)C1c1ccccc1,,CN(C)C=O,O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US04758548,CC(C=O)=CCC(C)CC(C)(C)C>>CC(C=O)CCC(C)CC(C)(C)C,[Pd],CO,,[H][H],,val
US20050239751A1,CC(C)(C)[Si](C)(C)OCC1OC(OCc2oc(=O)oc2CNc2cccc(-c3cc(-c4c(Cl)cccc4Cl)no3)c2)CC(O[Si](C)(C)C(C)(C)C)C1O[Si](C)(C)C(C)(C)C.O=C(Cl)C(Cl)Cl>>CC(C)(C)[Si](C)(C)OCC1OC(OCc2oc(=O)oc2CN(C(=O)C(Cl)Cl)c2cccc(-c3cc(-c4c(Cl)cccc4Cl)no3)c2)CC(O[Si](C)(C)C(C)(C)C)C1O[Si](C)(C)C(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04086219,COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12.COc1ccc(COC(=O)N[C@@H](COCc2ccccc2)C(=O)O)cc1>>COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)OCc1ccc(OC)cc1,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20070148164A1,CCCCC([Sn])=C(CCCC)CCCC.Cc1cc(Oc2nc(Br)c(F)cc2F)cc(-c2cccc(CNC(=O)OC(C)(C)C)c2)c1>>C=Cc1nc(Oc2cc(C)cc(-c3cccc(CNC(=O)OC(C)(C)C)c3)c2)c(F)cc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US06410790B1,C1CCNC1.O=C1CCC(c2ccccc2)CC1>>C1=C(N2CCCC2)CCC(c2ccccc2)C1,Cl[Ti](Cl)(Cl)Cl,CCCCCC,,,,val
US20150307483A1,CI.CS(=O)(=O)Nc1ccccc1[N+](=O)[O-]>>CN(c1ccccc1[N+](=O)[O-])S(C)(=O)=O,,CN(C)C=O,,[H-].[Na+],,val
US20160016936A1,CC(C)(C)OC(=O)N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)c[nH]2)C(F)C1.CC(C)(C)OC(=O)NCCBr>>CC(C)(C)OC(=O)NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(C(=O)OC(C)(C)C)CC1F,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20140249126A1,CC(C)(C)OC(=O)Nc1nc(C(=O)C(=O)O)c(Cl)s1.COc1ccc(COC(=O)[C@H](CC(=O)OC(C)(C)C)ON)cc1>>COc1ccc(COC(=O)[C@H](CC(=O)OC(C)(C)C)O/N=C(\C(=O)O)c2nc(NC(=O)OC(C)(C)C)sc2Cl)cc1,,CO,,,,val
US20100009975A1,CC(C)(C)OC(=O)N1CCC(N2CCSc3cc(NC(=N)c4cccs4)ccc32)C1>>N=C(Nc1ccc2c(c1)SCCN2C1CCNC1)c1cccs1,,CO,,Cl,,val
US20150165063A1,CNCCN(C)C(=O)Oc1cc2c(c3ccccc13)[C@H](CCl)CN2C(=O)CCCC(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21.O=C(Br)CBr>>CN(CCN(C)C(=O)Oc1cc2c(c3ccccc13)[C@H](CCl)CN2C(=O)CCCC(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21)C(=O)CBr,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US05356885,C#CCN1CC[C@@H](O)C1=O.CC(=O)OC(C)=O>>C#CCN1CC[C@@H](OC(C)=O)C1=O,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20020143044A1,COS(=O)(=O)OC.c1ccc(-c2ncc[nH]2)cc1>>Cn1ccnc1-c1ccccc1,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US05536725,CC1(C)Cc2cc(C3CCC(=O)CC3)ccc2O1>>CC1(C)Cc2cc(C3=CCC(=O)CC3)ccc2O1,[Pd],CCO,,,,val
US06046189,CCOC(=O)c1c(CN(CC)CC)nc2sc3c(c2c1-c1ccc(OC)c(OC)c1)CCNC3.S=C=Nc1ccccc1>>CCOC(=O)c1c(CN(CC)CC)nc2sc3c(c2c1-c1ccc(OC)c(OC)c1)CCN(C(=S)Nc1ccccc1)C3,,C1CCOC1,,,,val
US20100130557A1,O=C(Cl)Cc1ccccc1.O=[N+]([O-])c1ccc2[nH]ccc2c1>>O=C(Cc1ccccc1)n1ccc2cc([N+](=O)[O-])ccc21,,C1CCOC1,CCOC(C)=O,[H-].[Na+],[Cl-].[NH4+],val
US03979381,CCCNN.O=C1C(=Cc2ccc(Cl)cc2)CS(=O)(=O)CC1=Cc1ccc(Cl)cc1>>CCCN1N=C2C(=Cc3ccc(Cl)cc3)CS(=O)(=O)CC2C1c1ccc(Cl)cc1,,CO,,,,val
US20110071197A1,COC(=O)/C=C/c1cc(Oc2ccc(NC(=O)c3ccccc3)cc2)ccc1[N+](=O)[O-]>>COC(=O)/C=C/c1cc(Oc2ccc(NC(=O)c3ccccc3)cc2)ccc1N,[Fe],CC(C)O,,[Cl-].[NH4+],,val
US20160186094A1,CC(=O)O.CCCCCCCCCCCCC(C)c1ccccc1CBr>>CCCCCCCCCCCCC(C)c1ccc(COC(C)=O)cc1,,O,,CC(=O)[O-].[Na+],,val
US04391805,CC(=O)N1CCNCC1.Cc1cc(CN(C)C)cc(C)c1O>>CC(=O)N1CCN(Cc2cc(C)c(O)c(C)c2)CC1,,Cc1ccccc1C,,,,val
US06169097A,Cc1cc(C)cc(C(=O)N2CC[C@@H](N3CCC(O)CC3)C[C@@H]2Cc2ccccc2)c1.O=C(Cl)c1cc(Cl)cc(Cl)c1>>Cc1cc(C)cc(C(=O)N2CC[C@@H](N3CCC(OC(=O)c4cc(Cl)cc(Cl)c4)CC3)C[C@@H]2Cc2ccccc2)c1,,ClCCl,,CCN(CC)CC,,val
US20160015712A1,CCCCON=O.Cc1ccc2cc(Nc3nc(Cl)ncc3N)ccc2n1>>Cc1ccc2cc(-n3nnc4cnc(Cl)nc43)ccc2n1,,CC#N,,,,val
US20100216794A1,O=S(=O)(Cc1ccc(F)cc1)Cc1ccc(F)cc1.Oc1ccc(Br)nc1>>CS(=O)(=O)c1ccc(Oc2ccc(Br)nc2)cc1,,ClCCl,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US04435405,CC(=O)CCl.Fc1ccc(-c2cc3ccccc3[nH]c2=S)cc1>>CC(=O)CSc1nc2ccccc2cc1-c1ccc(F)cc1,,CN(C)C=O,,[H][H],[H-].[Na+],val
US20080194841A1,C/C=C/[C@H](C)C/C(N)=C/C(=O)OCC.CC(=O)OC(C)=O>>C/C=C/[C@H](C)C/C(=C/C(=O)OCC)NC(C)=O,,Cc1ccccc1,,c1ccncc1,,val
US20090318501A1,CC(C)(C)OC(=O)N[C@H](CO)C[C@H]1CCCOC1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N[C@H](COS(C)(=O)=O)C[C@H]1CCCOC1,,ClCCl,,CCN(CC)CC,,val
US04099003,CCCCNCCCC.S=C(Cl)Cl>>CCCCN(CCCC)C(=S)Cl,,CCOCC,,,,val
US20150259354A1,NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1NCC1(CN(Cc3ccccc3)C1)C2>>NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1NCC1(CNC1)C2,[Pd],CO,ClCCl,,,val
US20120238740A1,CCc1ccccc1Br.O=C(C1CCCCC1)C1CCCCC1>>OC(CCc1ccccc1)(C1CCCCC1)C1CCCCC1,,C1CCOC1,,,,val
US20090197834A1,O=C(O)c1cn(C2CCCC2)c2cc(NC3CCCCC3)c(F)cc2c1=O>>O=c1c(CO)cn(C2CCCC2)c2cc(NC3CCCCC3)c(F)cc12,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20130331374A1,CC(C)(C)[Si](C)(C)OCC1(CO[Si](C)(C)C(C)(C)C)Oc2ccc([N+](=O)[O-])cc2NC1=S.CCOC(=O)NN>>CCOC(=O)NNC1=Nc2cc([N+](=O)[O-])ccc2OC1(CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C,,CCO,,,,val
US06127563,CC1(C)CCC(C)(C)c2cc3c(cc21)CCC3=O.CCO>>CC1=Cc2cc3c(cc2C1)C(C)(C)CCC3(C)C,,CCOCC,,Cl,[BH4-].[Na+],val
US20050009831A1,NC(=O)c1c(Cl)c(-c2ccccc2)n2c1CNCC2.O=C(Cl)CCC1CCCCC1>>NC(=O)c1c(Cl)c(-c2ccccc2)n2c1CN(C(=O)CCC1CCCCC1)CC2,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20150105317A1,O=C(NCCO[C@@H]1O[C@H](CO[C@H]2O[C@H](COC(=O)c3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@H](OC(=O)c3ccccc3)[C@@H]2OC(=O)c2ccccc2)[C@@H](OCc2ccccc2)[C@H](O[C@H]2O[C@H](COC(=O)c3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@H](OC(=O)c3ccccc3)[C@@H]2OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1)OCc1ccccc1>>O=C(NCCO[C@@H]1O[C@H](CO[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H](OCc2ccccc2)[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)[C@H]1O)OCc1ccccc1,,CO,,CO[Na],,val
US06060508,CCN(CC)C(CO)c1cccc2c(C)c(C)oc12.CCN(CC)CC>>CCN(CC)CC(c1cccc2c(C)c(C)oc12)N(CC)CC,,ClCCl,,CS(=O)(=O)Cl,,val
US04009200,O=C1C=CC(=O)C2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl.OO>>O=C1C2OC2C(=O)C2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20080119521A1,NCCC1CCN(Cc2ccccc2)CC1.O=C(O)Cc1c[nH]c2ccccc12>>O=C(Cc1c[nH]c2ccccc12)NCCC1CCN(Cc2ccccc2)CC1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US04279918,CCOC1(OCC)CCCN1C.N#CCc1ccc([N+](=O)[O-])cc1>>CN1CCCC1=C(C#N)c1ccc([N+](=O)[O-])cc1,,c1ccccc1,,,,val
US20130123263A1,CCC1CC1.[N-]=[N+]=Nc1nc2c(s1)CCOc1cc(Br)ccc1-2>>Brc1ccc2c(c1)OCCc1sc(-n3nncc3C3CC3)nc1-2,,C1CCOC1,,CC[Mg]Br,,val
US20100035883A1,CCOC(OCC)c1ccc(C2Nc3cccc4c(=O)[nH]nc(c34)C2c2ccc(C(=O)N(C)C)cc2)cc1>>CN(C)C(=O)c1ccc(C2c3n[nH]c(=O)c4cccc(c34)NC2c2ccc(C=O)cc2)cc1,,CC#N,,O=C(O)C(F)(F)F,,val
US20120022056A1,CCOC(=O)c1ncn2c1CCc1c-2ccc(C)c1CCN1CCN(c2cccc3nc(C)ccc23)CC1.C[Si](C)(C)N[Si](C)(C)C.Cl.Cl>>Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCc4c(C(N)=O)ncn4-5)CC3)cccc2n1.Cl.Cl,,CO,ClCCl,Cl,[K+].[OH-],val
US20140045819A1,CC(=O)NN.S=C1CCc2c(ccc(Br)c2Cl)N1>>Cc1nnc2n1-c1ccc(Br)c(Cl)c1CC2,,CCCCO,,,,val
US20100210680A1,Brc1cccc(Br)c1.CN(C)C=O>>O=Cc1c(Br)cccc1Br,,C1CCOC1,,Cl,CC(C)[N-]C(C)C.[Li+],val
US20100280011A1,COC(=O)Cc1ccc(O[Si](C(C)C)(C(C)C)C(C)C)cc1.Cc1c(Br)ccc2c1C(=O)NC2=O>>COC(=O)C(CN1C(=O)c2ccccc2C1=O)c1ccc(O[Si](C(C)C)(C(C)C)C(C)C)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100093730A1,O=C(O)CN1CCCC(c2ccccc2)C1=O.c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>O=C(CN1CCCC(c2ccccc2)C1=O)N1CCN(C(c2ccccc2)c2ccccc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US03963706,NC1CCCCC1.O=C(CCl)Nc1ccc([N+](=O)[O-])cc1>>O=C(CNC1CCCCC1)Nc1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,O,,,val
US20060035912A1,CC(C)n1cc(Br)c2c(Cl)ncnc21.COc1cc(C(=O)N(C)OC)cc(N=C(c2ccccc2)c2ccccc2)n1>>COc1cc(C(=O)c2cn(C(C)C)c3ncnc(Cl)c23)cc(N=C(c2ccccc2)c2ccccc2)n1,,CCOCC,,[Li]CCCC,,val
US20060111375A1,BrCC1CO1.COc1cc2c(Oc3cc4cnccc4nc3C)ccnc2cc1O>>COc1cc2c(Oc3cc4cnccc4nc3C)ccnc2cc1OCC1CO1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06069176,COc1ccc(C2CCC(=O)C2)cc1.NCc1ccccc1>>COc1ccc(C2CCC(NCc3ccccc3)C2)cc1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090239854A1,Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.O=C(O)/C=C\c1ccc(C(F)(F)F)nc1>>Cc1ccc2c(c1)c1c(n2C(Cc2ccc(C(F)(F)F)nc2)C(=O)O)CCN(C)C1,,CN1CCCC1=O,,[K+].[OH-],,val
US20110034433A1,CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(=O)(=O)Cl)N(C)C(=O)N1c1cccc(C(F)(F)F)c1>>CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S)N(C)C(=O)N1c1cccc(C(F)(F)F)c1,,ClCCl,,,,val
US20110152296A1,O=Cc1ncccc1[N+](=O)[O-]>>Nc1cccnc1C=O,[Pd],CCO,,,,val
US20130317218A1,CCOC(=O)c1nc(Nc2ccc3ccccc3c2)sc1N.O=C(Cl)c1ccsc1>>CCOC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccsc1,,c1ccncc1,,,,val
US20080021032A1,CC(C)(C)OC(=O)NCC#CCn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)n1>>CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(CC#CCN)n2)cc1Cl,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,,val
US05089497,O=C(CCCCl)c1cccnc1.c1ccc(N2CCNCC2)nc1>>O=C(CCCN1CCN(c2ccccn2)CC1)c1cccnc1,,ClC(Cl)Cl,,[I-].[K+],,val
US05811428,CCOC=C(C(=O)OCC)C(=O)C(F)(F)F.N=C(N)C(F)(F)F>>CCOC(=O)c1cnc(C(F)(F)F)nc1C(F)(F)F,,CCO,,,,val
US20090275578A1,C=O.Cc1cc(CC2CCNCC2)cc2c1C(=O)N(Cc1ccc(OC(F)(F)F)cc1)C2>>Cc1cc(CC2CCN(C)CC2)cc2c1C(=O)N(Cc1ccc(OC(F)(F)F)cc1)C2,,CO,ClCCl,CC(=O)O,[BH3-]C#N.[Na+],val
US20100029615A1,CCI.O=C(NC1CCCC(c2nc3ccccc3[nH]2)C1)c1ccc2c(c1)OCCO2>>CCn1c(C2CCCC(NC(=O)c3ccc4c(c3)OCCO4)C2)nc2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090227622A1,CS(=O)(=O)c1ccc(B(O)O)cc1.Clc1ccn2ccnc2c1>>CS(=O)(=O)c1ccc(-c2ccn3ccnc3c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,COCCOC,O=C([O-])[O-].[Cs+].[Cs+],val
US20090209607A1,C=Cc1cnn(C)c1-c1csc(C(=O)OC)c1>>CCc1cnn(C)c1-c1csc(C(=O)OC)c1,[Pd],CCOC(C)=O,,,,val
US20150283134A1,Cc1ncc(C(C#N)=C2CCC(F)(F)CC2)cn1>>Cc1ncc(C(CN)C2CCC(F)(F)CC2)cn1,[Ni],CO,,N,O,val
US04289772,CCCCNC(=O)Nc1ccncc1>>CCCCNC(=O)NC1CCNCC1,[Rh],CCO,O,Cl,[H][H],val
US20080039457A1,CCOC(OCC)C(=O)c1ccccc1.NNC(N)=O>>NC(=O)NN=C(C=O)c1ccccc1,,CCO,O,Cl,,val
US20150158837A1,CC1CCCO1.O=C(O)[C@@H]1CCCN1.O=CCCC=O>>O=CC1=C[C@H]2CC(O)O[C@H]2C1,,CC1CCCO1,,C1CCOC1,,val
US20090004209A1,NC1CCC(=O)NC1=O.O=C(O)c1cccc(OCc2ccc(Cl)s2)c1C(=O)O>>O=C1CCC(N2C(=O)c3cccc(OCc4ccc(Cl)s4)c3C2=O)C(=O)N1,,c1ccncc1,,Cl,,val
US20150210647A1,CCOC(=O)C1CCN(Cc2ccc3ccc(O[C@H]4CC[C@@H](C(F)(F)F)CC4)c(Cl)c3c2)CC1>>O=C(O)C1CCN(Cc2ccc3ccc(O[C@H]4CC[C@@H](C(F)(F)F)CC4)c(Cl)c3c2)CC1,,CO,O,Cl,[Na+].[OH-],val
US04910190,COC(=O)CBr.NC(=O)c1ccc(O)cc1>>COC(=O)COc1ccc(C(N)=O)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20130150356A1,CC(C)COc1cc(N2CCNC(=O)C2)ncn1.ClCc1nc2ccccc2o1>>CC(C)COc1cc(N2CCN(Cc3nc4ccccc4o3)C(=O)C2)ncn1,,CN(C)C=O,,[H-].[Na+],,val
US05350748,CC(C)Oc1c(C(=O)O)oc2ccccc12.NCc1ccccc1>>CC(C)Oc1c(C(=O)NCc2ccccc2)oc2ccccc12,,C1CCOC1,CCOC(C)=O,O=C(n1ccnc1)n1ccnc1,,val
US20030078249A1,COc1cc(CC(=O)OCc2ccccc2)ccc1NC(=O)Nc1ccccc1F>>COc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1F,,C1CCOC1,,Cl,[Na+].[OH-],val
US20160016908A1,COC(=O)c1cc2c(cc1OC)N(C(C)=O)C(C1CC1)C(C)C2NC(=O)OCc1ccccc1>>COC(=O)c1cc2c(cc1OC)N(C(C)=O)C(C1CC1)C(C)C2N,[Pd],ClCCl,,CCO,,val
US20110281862A1,NCCc1ccc2c(c1)c1cc(Cl)cnc1n2S(=O)(=O)c1ccccc1.O=C(Cl)c1ccccc1>>O=C(NCCc1ccc2c(c1)c1cc(Cl)cnc1n2S(=O)(=O)c1ccccc1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US04822890,CC(C)(C)Oc1ccc(C[C@H](N)C(=O)O)cc1.O=C(Cl)OCC1c2ccccc2-c2ccccc21>>CC(C)(C)Oc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06143763,CNC1CCCCC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN(C(=O)Cl)C1CCCCC1,,Cc1ccccc1,,c1ccncc1,,val
US20020019527A1,CC(C)(C)OC(=O)N1CCN(c2cccc(OC(F)(F)F)c2)C(=O)C1.Cl>>Cl.O=C1CNCCN1c1cccc(OC(F)(F)F)c1,,CCOC(C)=O,CCOCC,,,val
US20070249670A1,CCOC(=O)c1c(N)sc2c1CCCC2>>Nc1sc2c(c1C(=O)O)CCCC2,,[Na+],[OH-],,,val
US20030158176A1,CI.Cc1ccc(O)c(C(CCN2CCCCCC2)c2ccccc2)c1>>Cc1ccc(O)c(C(CC[N+]2(C)CCCCCC2)c2ccccc2)c1.[I-],,ClCCl,,,,val
US04714492,BrBr.Cn1c(-c2ccccc2)cc(=O)c(C(=O)O)c1-c1ccccc1>>Cn1c(-c2ccccc2)c(Br)c(=O)c(C(=O)O)c1-c1ccccc1,,CO,O,[Na+].[OH-],,val
US20060235029A1,CCN.Cc1ccc(C(=O)O)cc1-c1nc(N2CCC(N3CCC(C)CC3)CC2)nc2c1ccc(=O)n2-c1c(F)cccc1F>>CCNC(=O)c1ccc(C)c(-c2nc(N3CCC(N4CCC(C)CC4)CC3)nc3c2ccc(=O)n3-c2c(F)cccc2F)c1,,C1CCOC1,CN(C)C=O,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110207815A1,CN.Cc1ccc(S(=O)(=O)OCC[C@@]2(O)CCc3cc(F)ccc3[C@@H]2C(C)C)cc1>>CNCC[C@@]1(O)CCc2cc(F)ccc2[C@@H]1C(C)C,,CCO,ClCCl,,,val
US20090036421A1,Cc1c(C(=O)N=C(N)N)cc(C2CCN(C(=O)OCc3ccccc3)CC2)n1CCc1ccc(F)cc1.ClC(Cl)Cl>>Cc1c(C(=O)N=C(N)N)cc(C2CCNCC2)n1CCc1ccc(F)cc1.Cl.Cl,[Pd],CCO,,,,val
US20130137680A1,CCOC(=O)c1ccc2cc(C(=O)OCC)n(C(C)CCNC(=O)OC(C)(C)C)c2n1>>CCOC(=O)c1ccc2cc(C(=O)OCC)n(C(C)CCN)c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060178363A1,FC(F)(F)c1cc2c(cn1)CNNC2.O=C(Cl)C(=O)Cl.O=C(OCc1ccccc1)[C@H]1CC[C@@H](N=C(c2ccccc2)c2ccccc2)C1>>NC(=O)C1NNCc2cnc(C(F)(F)F)cc21,,CN(C)C=O,ClCCl,CCN(CC)CC,Cl,val
US20040102384A1,O=C(CBr)OCc1ccccc1.O=C1CNC(=O)N1>>O=C(CN1C(=O)CNC1=O)OCc1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130116245A1,C[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cccc(-n4ncc5c6c(sc5c4=O)CCCC6)c3C=O)cn(C)c2=O)nc1>>C[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cccc(-n4ncc5c6c(sc5c4=O)CCCC6)c3CO)cn(C)c2=O)nc1,,CO,,[BH4-].[Na+],,val
US20060084680A1,Cc1cnc(Cl)nc1Cl.NCCCO>>Cc1cnc(Cl)nc1NCCCO,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20060194841A1,CCCC(=O)NCC(CC(O)CO)(c1ccc(Cl)c(Cl)c1)N(C)C(=O)OC(C)(C)C>>CCCC(=O)NCC(CC=O)(c1ccc(Cl)c(Cl)c1)N(C)C(=O)OC(C)(C)C,,C1CCOC1,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US04352817,CN1Cc2c(C(=O)OC(C)(C)C)ncn2-c2ccccc2C1=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CN1Cc2c(C(=O)OC(C)(C)C)ncn2-c2ccccc2C1=S,,Cc1ccccc1,,O,,val
US20090318408A1,CCOc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C>>CCOc1cc(C(=O)NC2CCNCC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040002608A1,CCn1c(C=O)nc(C)c1Br>>CCn1c(CO)nc(C)c1Br,,CO,,[BH4-].[Na+],,val
US20100197908A1,CC(=O)N(C)CC1CCN(C(=O)OC(C)(C)C)CC1.O=C(O)C(F)(F)F>>CC(=O)N(C)CC1CCNCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20140005187A1,COc1ccc(C(=O)c2ccc(Br)cc2)c(F)c1>>O=C(c1ccc(Br)cc1)c1ccc(O)cc1F,,CC(=O)O,,Br,,val
US05969146,BrCc1ccccc1.CCOC(=O)Nc1csc2cc(O)ccc12>>CCOC(=O)Nc1csc2cc(OCc3ccccc3)ccc12,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100210641A1,BrBr.Brc1ccc2nccn2c1>>Brc1ccc2ncc(Br)n2c1,,CC(=O)O,,,,val
US20140179720A1,CC(C)(C)OC(=O)Nc1cccc(N)c1.Fc1cnc(Cl)nc1Cl>>CC(C)(C)OC(=O)Nc1cccc(Nc2nc(Cl)ncc2F)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20090275620A1,CCOC(=O)[C@H]1CC[C@@H](Oc2ccc(NC(=O)C(=O)OC)cc2)CC1.NN>>CCOC(=O)[C@@H]1CC[C@H](Oc2ccc(NC(=O)C(=O)NN)cc2)CC1,,CCO,,O,,val
US06307056B1,COC(=O)c1ccc(-c2c(NC(=O)Cc3cccs3)ccc3c2/C(=C/c2[nH]ccc2OC)C(=O)N3)cc1>>COc1cc[nH]c1/C=C1\C(=O)Nc2ccc(NC(=O)Cc3cccs3)c(-c3ccc(C(=O)O)cc3)c21,,C1CCOC1,O,[Li]O,,val
US20070287724A1,Cc1nc(Cl)c([N+](=O)[O-])c(Cl)c1C.NCC1(O)CCOCC1>>Cc1nc(Cl)c([N+](=O)[O-])c(NCC2(O)CCOCC2)c1C,,CN(C)C=O,,CCN(CC)CC,,val
US20040058959A1,CCOc1cc(F)ccc1C(=O)Nc1ccc(F)cc1C(=O)Nc1ccc(Cl)cn1.CN1CCCNCC1>>CCOc1cc(N2CCCN(C)CC2)ccc1C(=O)Nc1ccc(F)cc1C(=O)Nc1ccc(Cl)cn1,,CS(C)=O,ClCCl,,,val
US20090163512A1,C=C(N=Cc1cc(Cl)ccc1C)O[Si](C)(C)C.CCCC(CCC)(Oc1ccc(Cl)cc1/C=C1\C(=O)N(C(=O)OC(C)(C)C)c2cc(Cl)ccc21)C(=O)OCC>>CCCC(CCC)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(Cl)ccc2C)C12C(=O)Nc1cc(Cl)ccc12)C(=O)OCC,,Cc1ccccc1,,,,val
US20160222030A1,CN[C@H]1CCC[C@@H]1Nc1nc2ccc(F)cc2s1.COc1cccc(OC)c1C(=O)Cl>>COc1cccc(OC)c1C(=O)N(C)[C@H]1CCC[C@@H]1Nc1nc2ccc(F)cc2s1,,ClCCl,,CCN(CC)CC,,val
US20040229949A1,CCCCCCOC(Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)cc1)C(=O)OC>>CCCCCCOC(Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)cc1)C(=O)O,,C1CCOC1,O,[Li+].[OH-],,val
US04230623,COc1ccc(C(=O)CC(c2cccs2)C(C)(C)[N+](=O)[O-])cc1>>COc1ccc(C2=NC(C)(C)C(c3cccs3)C2)cc1,[Zn],O=CO,,CCO,,val
US20150119362A1,CCCNC.CCc1cc(Cc2ccc(CC(=O)Cl)cc2)nc(-c2cccc(Cl)c2)n1>>CCCN(C)C(=O)Cc1ccc(Cc2cc(CC)nc(-c3cccc(Cl)c3)n2)cc1,,ClCCl,O,CCN(C(C)C)C(C)C,Cl,val
US03996376,O=C(C(F)(F)F)C(F)(F)F.O=C1OCC(CO)O1>>OCC1COC(C(F)(F)F)(C(F)(F)F)O1,,O,,O=C=O,,val
US20090143456A1,O=C(O)C1(c2ccccc2)CC1.[N-]=[N+]=[N-]>>NC1(c2ccccc2)CC1,,ClC(Cl)Cl,,O=S(=O)(O)O,,val
US04066635,COC(=O)CCNC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C.N>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NCCC(N)=O,,CO,,,,val
US20110034440A1,CCOC(=O)CN(CC(=O)OCC)c1cc(CCC(=O)OC(C)(C)C)ccc1C>>CCOC(=O)CN(CC(=O)OCC)c1cc(CCC(=O)O)ccc1C,,ClCCl,,C1COCCO1,Cl,val
US05656197,COC(=O)c1ccc(O)cc1.O=C([O-])c1ccc(OCCOCCO)cc1.OCCOCCCl>>COC(=O)c1ccc(OCCOCCOCCO)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05321135,COc1cc(CC2COC(=O)C2Cc2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC>>COc1cc2c(c(OC)c1OC)-c1c(cc(OC)c(OC)c1OC)CC1C(=O)OCC1C2,,CCOC(C)=O,,ClCCl,O=C(O)C(F)(F)F,val
US20100305070A1,Cc1cc(=O)oc2cc(N=C=O)ccc12.OCc1ccc(-c2ccco2)cc1>>Cc1cc(=O)oc2cc(NC(=O)OCc3ccc(-c4ccco4)cc3)ccc12,,C1CCOC1,,,,val
US20100144825A1,CC(C)(C)OC(=O)N1[C@@H](C[C@H]2CCCOC2)COC1(C)C>>N[C@H](CO)C[C@H]1CCCOC1,,O,O=C(O)C(F)(F)F,,,val
US20040023968A1,COP(=O)(OC)C1OC(=O)c2ccccc21.COc1ccc(C=O)cc1[N+](=O)[O-]>>COc1ccc(C=C2OC(=O)c3ccccc32)cc1[N+](=O)[O-],,C1CCOC1,,CCN(CC)CC,,val
US05155106,CCCCCCCCSCCN.CCOC(=O)Cl.COc1ccc(C(=O)O)c(O)c1>>CCCCCCCCSCCNC(=O)c1ccc(OC)cc1OC(=O)OCC,,CCN(CC)CC,ClCCl,Cl,,val
US20130023629A1,C=CCNCC=C.Clc1nc(Cl)nc(Cl)n1>>C=CCN(CC=C)c1nc(Cl)nc(Cl)n1,,C1COCCO1,,[Na+].[OH-],,val
US04939162,CC1CCOC(CBr)(c2ccc(Cl)cc2Cl)O1.c1nc[nH]n1>>CC1CCOC(Cn2cncn2)(c2ccc(Cl)cc2Cl)O1,,CS(C)=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US05595989,ClCCCBr.c1ccc2c(c1)Nc1ccccc1O2>>ClCCCN1c2ccccc2Oc2ccccc21,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20080319012A1,CS(=O)(=O)Cl.Cc1cccc(-c2[nH]c(Cc3ccc(N)cc3)nc2-c2ccc3ncccc3c2)n1>>Cc1cccc(-c2[nH]c(Cc3ccc(NS(C)(=O)=O)cc3)nc2-c2ccc3ncccc3c2)n1,,c1ccncc1,,,,val
US04829071,CNC1Cc2ccc(NS(C)(=O)=O)cc2C1.CS(=O)(=O)Nc1ccc2nc(CCl)ccc2c1>>CN(Cc1ccc2cc(NS(C)(=O)=O)ccc2n1)C1Cc2ccc(NS(C)(=O)=O)cc2C1,,CC#N,,O=C([O-])O.[Na+],,val
US20130296569A1,COCC1(O)CCN(c2c(F)cc(N3C[C@H](CO)OC3=O)cc2F)CC1.CS(=O)(=O)Cl>>COCC1(O)CCN(c2c(F)cc(N3C[C@H](COS(C)(=O)=O)OC3=O)cc2F)CC1,,ClCCl,,CCN(CC)CC,O,val
US20070281933A1,CNC.NC(=O)c1cc(-c2ccsc2)cc2c(C3CCN(S(=O)(=O)CCCCl)CC3)n[nH]c12>>CN(C)CCCS(=O)(=O)N1CCC(c2n[nH]c3c(C(N)=O)cc(-c4ccsc4)cc23)CC1,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US04230696,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O>>N[C@@H](Cc1ccc(O)cc1)C(=O)O,,CN(C)C=O,,ClCCl,,val
US20040132717A1,CCOC(=O)C(Br)CC.O=C1CCC(c2ccccc2)CN1>>CCOC(=O)C(CC)N1CC(c2ccccc2)CCC1=O,,Cc1ccccc1,,CCOC(C)=O,CC(C)(C)[O-].[K+],val
US20110009449A1,CCC(=O)Cl.O=C(OCc1ccccc1)N1CCC(Nc2ccc(F)c(F)c2)CC1>>CCC(=O)N(c1ccc(F)c(F)c1)C1CCN(C(=O)OCc2ccccc2)CC1,,ClCCl,,CCN(CC)CC,,val
US05292732,CC(=O)NCCn1ccc2c1-c1ccccc1C(C)C2>>CC(=O)NCCn1ccc2cc(C)c3ccccc3c21,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US05756507,Cc1cc(C)cc(-c2[nH]c3ccc([N+](=O)[O-])cc3c2CCN(CCCCc2ccc(NS(C)(=O)=O)cc2)Cc2ccccc2)c1>>Cc1cc(C)cc(-c2[nH]c3ccc(N)cc3c2CCN(CCCCc2ccc(NS(C)(=O)=O)cc2)Cc2ccccc2)c1,[Ni],,,[H][H],,val
US20150232444A1,C#CCBr.O=S(=O)(c1ccccc1)N1CCC(N2CCC(CCO)CC2)CC1>>C#CCOCCC1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1,,C1CCOC1,,,,val
US20090018122A1,CC(C)(CNc1c(N)cnc2ccc(OCc3ccccc3)cc12)NC(=O)OC(C)(C)C.CCOCC(=O)Cl>>CCOCc1nc2cnc3ccc(OCc4ccccc4)cc3c2n1CC(C)(C)NC(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20140005183A1,C1COCCN1.OC1(c2c[nH]c3ncnc(Cl)c23)CCCOC1>>OC1(c2c[nH]c3ncnc(N4CCOCC4)c23)CCCOC1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20070287696A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.[N-]=[N+]=N[C@H]1CCC[C@@H](c2ccccc2)NC1=O>>CC(C)(C)OC(=O)N[C@H]1CCC[C@@H](c2ccccc2)NC1=O,[Pd],CCO,ClCCl,CCN(CC)CC,,val
US06881728B1,C[C@@]12CCC[C@H]1[C@@H]1CCC3=CC(=O)CC[C@@H]3[C@H]1CC2.C[C@]12CC[C@@H]3[C@H]4CCC(=O)C=C4CC[C@H]3[C@H]1CC[C@H]2CO>>CC[C@@H]1CC2=CC(=O)CC[C@@H]2[C@H]2CC[C@]3(C)[C@H](CO)CC[C@@H]3[C@@H]21,,C1COCCO1,,,,val
US20110009354A1,CCOC(=O)CCN(C)C[C@H]1O[C@@H](n2c(C)nc3c(N)ncnc32)[C@H](O)[C@@H]1O.NN.O=S(=O)(O)O>>Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](CN(C)CCC(=O)NN)[C@@H](O)[C@H]1O.O=S(=O)(O)O,,CCO,CCO,O,,val
US04410520,CCOC(=O)CNc1ccccc1CCC(NC(CCc1ccccc1)C(=O)OCC)C(=O)OCC>>CCOC(=O)CN1C(=O)C(NC(CCc2ccccc2)C(=O)OCC)CCc2ccccc21,,CO,,C[O-].[Na+],,val
US04871852,O=C(O)c1cc(F)c(F)cc1F.O=S(Cl)Cl>>O=C(Cl)c1cc(F)c(F)cc1F,,c1ccccc1,,,,val
US20140206663A1,CC1C(=O)N(COCC[Si](C)(C)C)N=C2COc3cc(-c4ccccc4F)c(N4C[C@H](C)N(C(=O)OC(C)(C)C)C[C@H]4C)cc3N21>>CC1C(=O)NN=C2COc3cc(-c4ccccc4F)c(N4C[C@H](C)N(C(=O)OC(C)(C)C)C[C@H]4C)cc3N21,,O,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090149472A1,N#CS.O=C(NN1CCCCC1)C1=NN(c2ccc(Cl)cc2Cl)C(c2ccc(Cl)cc2)C1>>N#C[S-].O=C(NN1CCCCC1)C1=NN(c2ccc(Cl)cc2Cl)C(c2ccc(Cl)cc2)C1,,CCOC(C)=O,,,,val
US20120329830A1,CS(=O)(=O)OC1CCOC2(CCC2)C1.C[Si](C)(C)N=[N+]=[N-]>>[N-]=[N+]=NC1CCOC2(CCC2)C1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05362742,CC(=O)Oc1c(C)c(C)c2c(c1C)CC(C)(C(=O)Nc1cnc3c(C)cc(C)cc3c1-c1ccccc1Cl)O2>>Cc1cc(C)c2ncc(NC(=O)C3(C)Cc4c(C)c(O)c(C)c(C)c4O3)c(-c3ccccc3Cl)c2c1,,O,,CO,Cl,val
US20020045635A1,CCI.Cc1nc(N2CCc3nc(C)sc3CC2)c([N+](=O)[O-])c(=O)[nH]1>>CCOc1nc(C)nc(N2CCc3nc(C)sc3CC2)c1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070265265A1,CI.Nc1ccc(-c2csc(NC(=O)[C@@H]3CCCN3C(=O)OCc3ccccc3)n2)cc1>>CNc1ccc(-c2csc(NC(=O)C3CCCN3C(=O)OCc3ccccc3)n2)cc1,,ClCCl,,CCN(CC)CC,,val
US20110034438A1,CC(C)(C)OC(=O)N1C(=O)CCC1CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C>>CC(C)(C)OC(=O)N1C(O)CC[C@H]1CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20120269804A1,CC(C)(C)OC(=O)NS(=O)(=O)NCc1cccc(O)c1.O=[N+]([O-])c1c(F)cc(F)cc1Nc1ccc(I)cc1F>>CC(C)(C)OC(=O)NS(=O)(=O)NCc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2[N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070004772A1,COc1ccc(B(O)O)cc1.Cc1nc(C(F)(F)F)ccc1Cn1nc2c(-c3ccncc3)c(Cl)ccn2c1=O>>COc1ccc(-c2ccn3c(=O)n(Cc4ccc(C(F)(F)F)nc4C)nc3c2-c2ccncc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20150080392A1,NCCc1ccc(O)cc1.O=Cc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1>>Oc1ccc(CCNCc2ccc(-c3ccc4ncnc(Nc5ccc(OCc6cccc(F)c6)c(Cl)c5)c4c3)o2)cc1,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20100041719A1,CONC(=O)OC(C)(C)C.O=C(CCCl)c1ccccc1>>CON(CCC(=O)c1ccccc1)C(=O)OC(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US06794390B2,CC(C)I.COc1ccc(CNc2nc(Cl)nc3c2ncn3C(C)C)cc1>>CC(C)c1ncc2[nH]cnc2n1,,CN(C)C=O,,O,[H-].[Na+],val
US20130225556A1,C[Si](C)(C)CCOCn1ccc2c(-c3cn[nH]c3)ncnc21.N#CC=C1CC(CC#N)(CC#N)C1>>N#CCC1(CC#N)CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US05840732,CCCC=O.O=C1CSC(=O)N1CCCSc1cccc2nccn12>>CCCC=C1SC(=O)N(CCCSc2cccc3nccn23)C1=O,,CCO,,C1CCNCC1,,val
US20090036492A1,COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.Cc1cc(OCc2ccc(F)cc2)c2ccccc2c1C=O>>COc1cc(O)c2c(c1C(=O)NCc1c(C)cc(OCc3ccc(F)cc3)c3ccccc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,,CC#N,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US04736056,BrCCBr.CCOC(=O)CC(=O)Nc1ccc(C#N)cc1>>CCOC(=O)C1(C(=O)Nc2ccc(C#N)cc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090054463A1,CCOC(=O)CC(c1ccc(F)cc1)c1ccc(F)cc1>>OCCC(c1ccc(F)cc1)c1ccc(F)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150307451A1,COC(=O)c1cc(Cc2ccc(-n3cccn3)cc2)c(C#N)c(C)c1O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1cc(Cc2ccc(-n3cccn3)cc2)c(C#N)c(C)c1OS(=O)(=O)C(F)(F)F,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20090306043A1,CC(O)C1CNCC1c1ccc(Cl)c(Cl)c1.O=C(/N=N/C(=O)OCc1ccccc1)OCc1ccccc1.Oc1ccc(Cl)cn1>>CC(Oc1ccc(Cl)cn1)C1CN(Cc2ccccc2)CC1c1ccc(Cl)c(Cl)c1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160221945A1,N#Cc1cnc(CNC(=O)[C@@H]2C[C@@H](F)CN2)cc1-c1ccc(C(F)(F)F)nc1.O=S(=O)(Cl)c1ccc(F)cc1>>N#Cc1cnc(CNC(=O)[C@@H]2C[C@@H](F)CN2S(=O)(=O)c2ccc(F)cc2)cc1-c1ccc(C(F)(F)F)nc1,,ClCCl,O,Cl,,val
US20150045378A1,Br[Mg]C1CC1.COc1cc(C#N)ncn1.O=C([O-])O>>COc1cc(C(=O)C2CC2)ncn1,,C1CCOC1,,Cl,,val
US20020099089A1,COC(=O)c1ccccc1NC(=O)/C=C/c1ccc2ccccc2c1Br>>O=C(/C=C/c1ccc2ccccc2c1Br)Nc1ccccc1C(=O)O,,CO,,[Na+].[OH-],,val
US20070249688A1,COC(=O)c1ccc(C(CC(C)(C)C)Oc2cnc(Cl)c(C)c2)cc1>>Cc1cc(OC(CC(C)(C)C)c2ccc(C(=O)O)cc2)cnc1Cl,,CO,,[Na+].[OH-],,val
US20060205718A1,CCOc1cc(OC2CCOCC2)cc(C(=O)OC)c1>>CCOc1cc(C=O)cc(OC2CCOCC2)c1,O=[Mn]=O,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160108047A1,CCOC(=O)c1cn(C2CC2)c(Br)n1.O=Cc1ccc(Cl)cc1>>CCOC(=O)c1nc(Br)n(C2CC2)c1C(O)c1ccc(Cl)cc1,,CCCCCC,CCOC(C)=O,,,val
US20040248875A1,CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3cc(CN)c(N)n3CCO)CS[C@H]12)c1nsc(N)n1)C(=O)O.O=S(=O)(O)O>>CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(C[n+]3cc(CN)c(N)n3CCO)CS[C@H]12)c1nsc(N)n1)C(=O)O.O=S(=O)([O-])O,,O,,CC#N,,val
US20160108047A1,CCOC(=O)c1cn(C(C)C)c(C2=COCC2)n1>>CCOC(=O)c1cn(C(C)C)c(C2CCOC2)n1,[Pd],CCO,,,,val
US20120270819A1,COc1ccc(C(=O)c2ccccc2OC)cc1>>COc1ccc(C(=O)c2ccccc2O)cc1,,ClCCl,,,,val
US20090264445A1,CC(C)(C)CCC(C(=O)O)N1CC(Oc2ccccc2Cl)=CC1=O.CC1(C)OC[C@@H](Cn2ccc(N)n2)O1>>CC(C)(C)CCC(C(=O)Nc1ccn(C[C@@H]2COC(C)(C)O2)n1)N1CC(Oc2ccccc2Cl)=CC1=O,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US07262201B1,COCCOc1cc2ncnc(Cl)c2cc1OC.COc1ccc(C2=NNC(=O)C2)cc1>>COCCOc1cc2ncnc(Oc3cc(-c4ccc(OC)cc4)[nH]n3)c2cc1OC,,CN(C)C=O,,[H-].[Na+],,val
US20100152155A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=[N+]([O-])C1C2CNCC21>>CC(C)(C)OC(=O)N1CC2C(C1)C2[N+](=O)[O-],CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,Cl,val
US20130296605A1,CC(C)Oc1ccc(C(=O)c2cccc(C(=O)c3ccc(OC(C)C)cc3)c2)cc1.NNC(N)=S>>CC(C)Oc1ccc(C(=O)c2cccc(C(=NNC(N)=S)c3ccc(OC(C)C)cc3)c2)cc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120258953A1,COC(=O)c1ccc(-c2ccc3c(c2)CN(C(=O)OC(C)(C)C)CCO3)cc1>>CC(C)(C)OC(=O)N1CCOc2ccc(-c3ccc(C(=O)O)cc3)cc2C1,,C1CCOC1,O,[Li+].[OH-],,val
US20110112158A1,COCCN(C(=O)OC(C)(C)C)c1noc2ccc(COc3ccc(-c4cc(F)c(F)cc4OC)cc3)cc12>>COCCNc1noc2ccc(COc3ccc(-c4cc(F)c(F)cc4OC)cc3)cc12,,CCOC(C)=O,,ClCCl,O=C(O)C(F)(F)F,val
US04057416,CSC(SC)=C(C#N)C#N.N>>CSC(N)=C(C#N)C#N,,CCO,,,,val
US20090118164A1,C=CCCCC(=O)O.CO>>C=CCCCC(=O)OC,,CCOCC,,C[Si](C)(C)C=[N+]=[N-],,val
US20030004157A1,C1CSCCN1.O=[N+]([O-])c1ccc(Cl)nc1>>O=[N+]([O-])c1ccc(N2CCSCC2)nc1,,C1CCOC1,,,,val
US20140018313A1,CC(C)[Si](Oc1cccc2cc(Br)ccc12)(C(C)C)C(C)C.CON(C)C(=O)CCl>>CC(C)[Si](Oc1cccc2cc(C(=O)CCl)ccc12)(C(C)C)C(C)C,,C1CCOC1,,[Li]CCCC,,val
US20100317645A1,CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(=O)NN)cc32)cc1.S=C(Cl)Cl>>CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(-c4n[nH]c(=S)o4)cc32)cc1,,C1CCOC1,,,,val
US20150018341A1,CC/C(=C(/c1ccc(O)cc1)c1ccc(OCCCl)cc1)c1ccc2c(c1)ncn2C.CN>>CC/C(=C(/c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccc2c(c1)ncn2C,,CO,,,,val
US20030036557A1,CS(=O)(=O)c1ccc(NC(=N)c2ccc(Cl)cc2)cc1.O=C(CBr)CSc1ccccc1>>CS(=O)(=O)c1ccc(N2CC(O)(CSc3ccccc3)N=C2c2ccc(Cl)cc2)cc1,,CC(C)=O,,O=C([O-])O.[Na+],,val
US20160221972A1,COC(=O)c1ccc2c(c1)NC(=O)CN(C(=O)OC(C)(C)C)C2.Cl>>COC(=O)c1ccc2c(c1)NC(=O)CNC2.Cl,,C1COCCO1,,,,val
US20140088124A1,CCOC(=O)[C@@H]1CC[C@@H](OC2CCN(c3ccc(-c4nc5cc(C(F)(F)F)ccc5[nH]4)cn3)CC2)CC1>>O=C(O)[C@@H]1CC[C@@H](OC2CCN(c3ccc(-c4nc5cc(C(F)(F)F)ccc5[nH]4)cn3)CC2)CC1,,C1CCOC1,O,[Li+].[OH-],,val
US20160075720A1,[N-]=[N+]=NC[C@@H]1CNc2c(sc3ccc4nc(Nc5cc(F)ncn5)ccc4c23)C(=O)N1>>NC[C@@H]1CNc2c(sc3ccc4nc(Nc5cc(F)ncn5)ccc4c23)C(=O)N1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070219196A1,CCOC(=O)CCNc1c([N+](=O)[O-])cnc2ccccc12>>CCOC(=O)CCNc1c(N)cnc2ccccc12,[Pt],,,,,val
US20020133015A1,COC(=O)[C@@H](N)Cc1ccc(-c2c(C)cc(C(F)(F)F)n(C)c2=O)cc1.O=C(Cl)c1c(Cl)cccc1Cl>>COC(=O)[C@H](Cc1ccc(-c2c(C)cc(C(F)(F)F)n(C)c2=O)cc1)NC(=O)c1c(Cl)cccc1Cl,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,Cl,val
US20080318968A1,COC(=O)c1cc(OCc2ccccc2)cc(O[C@@H](C)COC(F)F)c1>>COC(=O)c1cc(O)cc(O[C@@H](C)COC(F)F)c1,,CCO,,,,val
US20140350005A1,CN(C)CCOC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCN(C(=O)OC(C)(C)C)CC3)C2=O)c1>>CN(C)CCOC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCNCC3)C2=O)c1,,C1COCCO1,,Cl,,val
US20070293502A1,CCN(CC)C(=O)c1ccc(C(c2cccc(N)c2)N2CCN(C(=O)OC(C)(C)C)CC2)cc1.COC(=O)Cl>>CCN(CC)C(=O)c1ccc([C@@H](c2cccc(NC(=O)OC)c2)N2CCNCC2)cc1,[Zn],Cc1ccccc1,,,,val
US20080207654A1,CCCCc1nc(C)n(-c2ccc3c(c2)CCO3)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1F.O=C([O-])O.[NH3+]O>>CCCCc1nc(C)n(-c2ccc3c(c2)CCO3)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1F,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20060229309A1,CCCN(CCC)C(=O)c1cccc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2COCCN2C(c2ccccc2)c2ccccc2)c1>>CCCN(CCC)C(=O)c1cccc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2COCCN2)c1,[Pd],CO,,CC(=O)O,,val
US20130150326A1,CCOC(=O)c1cccc(Sc2c(C)n(C#N)c3c(F)c(Cl)ccc23)c1.NO>>CCOC(=O)c1cccc(Sc2c(C)n(C(=N)NO)c3c(F)c(Cl)ccc23)c1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20070249593A1,C[Si](C)(C)CCOCn1cc(C#N)nc1C(=O)Nc1ccc(C2CNC(=O)NC2)cc1C1=CCCCC1.O=C(O)C(F)(F)F>>N#Cc1c[nH]c(C(=O)Nc2ccc(C3CNC(=O)NC3)cc2C2=CCCCC2)n1.O=C(O)C(F)(F)F,,ClCCl,,CCO,,val
US20150038528A1,COC(=O)C[C@H](NC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)c1cccnc1>>N#Cc1nc(C(=O)N[C@@H](CC(=O)O)c2cccnc2)c(O)c2ccc(Oc3ccccc3)cc12,,CO,,C1CCOC1,[Na+].[OH-],val
US20150175602A1,CC(C)(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CNCC2.CN(C)C(=O)Cl.O=C(O)C(F)(F)F>>CN(C)C(=O)N1CCc2nc(NC(C)(C)C)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1.O=C(O)C(F)(F)F,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20140315888A1,CC1(NC(=O)OC(C)(C)C)CNC1.Clc1nc2cc(Br)cnc2nc1Cl>>CC1(NC(=O)OC(C)(C)C)CN(c2nc3ncc(Br)cc3nc2Cl)C1,,ClCCl,,Cl,,val
US05658935,CCOC(=O)CC(CCc1ccc(C=NN)cc1)(C(=O)OCC)C(=O)OCC.Cl>>CCOC(=O)C(CCc1ccc(C=NN)cc1)(CC(=O)O)C(=O)OCC.Cl,,Cl,,,,val
US20040082619A1,CCCCn1cc2c(c(C#N)c1=O)CCCC2=O>>CCCCn1cc2c(c(C#N)c1=O)CCCC2O,,C1CCOC1,,Cl,[BH4-].[Na+],val
US20120225854A1,COc1cccc(CC2CNCCN2)n1.O=S(=O)(Cl)c1cccs1>>COc1cccc(CC2CN(S(=O)(=O)c3cccs3)CCN2)n1,,O=C([O-])O,[Na+],CCN(CC)CC,ClCCl,val
US20070078184A1,BrCc1ccccc1.C[C@H](NC(=O)C(F)(F)F)[C@H](O)c1ccc(O)c([N+](=O)[O-])c1>>C[C@H](NC(=O)C(F)(F)F)[C@H](O)c1ccc(OCc2ccccc2)c([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05011825,CC(C)(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCNC(=N)N.CC(C)(C)SSC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.CCN1CCOCC1.CN(C)C=O>>CC(=O)O.CC(C)(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CSSC(C)(C)C)NC(=O)OCC1c2ccccc2-c2ccccc21,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20120101110A1,CO.ClCc1cccc(Cl)n1>>COCc1cccc(Cl)n1,,CO,,C[O-].[Na+],,val
US20070010670A1,Cc1ccc2c(c1)OCCN2.O=C(Cl)c1cc(Cl)c(O)c(Cl)c1>>Cc1ccc2c(c1)OCCN2C(=O)c1cc(Cl)c(O)c(Cl)c1,,CCOC(C)=O,,,,val
US20090105259A1,CC(C)C[C@H](N)C(=O)NCCCCNS(=O)(=O)c1ccc(F)cc1C(F)(F)F.NCC1CCCCC1.O=C=NC1CCCCC1>>CC(C)C[C@H](NC(=O)NCC1CCCCC1)C(=O)NCCCCNS(=O)(=O)c1ccc(F)cc1C(F)(F)F,,C1CCOC1,,CCN(CC)CC,,val
US20150274624A1,CC(C)(C)C(=O)OCCOc1ccc(/C(=C(/CCCl)c2ccccc2)c2ccccc2)cc1>>OCCOc1ccc(/C(=C(/CCCl)c2ccccc2)c2ccccc2)cc1,,Cc1ccccc1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080255162A1,CSc1nc(C)c2cc(Cl)c(=O)n(C3CCCC3)c2n1.O=C(OO)c1cccc(Cl)c1>>Cc1nc(S(C)=O)nc2c1cc(Cl)c(=O)n2C1CCCC1,,ClC(Cl)Cl,,,,val
US20100029650A1,CC(C)OC(=O)N1CCC(COc2ccc(Br)nc2)CC1.OCc1ccc(B(O)O)cc1>>CC(C)OC(=O)N1CCC(COc2ccc(-c3ccc(CO)cc3)nc2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20030139418A1,CCN.O=[N+]([O-])c1ccccc1CBr>>CCNCc1ccccc1[N+](=O)[O-],,C1CCOC1,,O,[Na+].[OH-],val
US20150087639A1,CC(=O)C=C=O.CCCCCCN(CCCCCC)c1ccc(N)cc1C#N>>CCCCCCN(CCCCCC)c1ccc(NC(=O)CC(C)=O)cc1C#N,,CCOC(C)=O,,,,val
US20070185111A1,CN.Fc1cc(-c2cnccc2Oc2ccc(Nc3nnc(-c4ccccc4)c4ccccc34)cc2)ccn1>>CNc1cc(-c2cnccc2Oc2ccc(Nc3nnc(-c4ccccc4)c4ccccc34)cc2)ccn1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20130096113A1,CCOC(=O)c1ccc2nc(Br)sc2c1>>OCc1ccc2nc(Br)sc2c1,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US05154851,C#Cc1ccc(-c2ccc(CCC)cc2)cc1.CC#Cc1ccc(I)cc1>>CC#Cc1ccc(C#Cc2ccc(-c3ccc(CCC)cc3)cc2)cc1,I[Cu]I,,,CCNCC,,val
US06034275,C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(N)c1.CS(=O)(=O)Cl>>C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(NS(C)(=O)=O)c1,,ClCCl,,CN(C)c1ccccn1,,val
US05079093,C=CC(=O)OCC1CO1.C=CN1CCCC1=O.C=COC(C)=O>>C=CC(=O)OCC1CO1.C=CN1CCCC1=O.C=COC(C)=O,,CCO,,,,val
US20060122212A1,CCOC(=O)c1cc2c(ccc(=O)n2-c2ccccc2)n1Cc1cccc(Cl)c1.NN>>NNC(=O)c1cc2c(ccc(=O)n2-c2ccccc2)n1Cc1cccc(Cl)c1,,CCOCCO,,O,,val
US20090197882A1,COC(=O)c1cc2c(Cc3cccc(C)c3)n[nH]c2cc1O>>Cc1cccc(Cc2n[nH]c3cc(O)c(C(=O)O)cc23)c1,,C1COCCO1,,[Na+].[OH-],,val
US06270948B1,COC.Cl[c-]1cccc1.Cl[c-]1cccc1.[Zr+2]>>C[c-]1cccc1.[Zr+2].c1cc[cH-]c1,,CCOCC,,,,val
US20100105607A1,CCCCCCO.O=C(O)CBr>>CCCCCCOCC(=O)O,,C1CCOC1,,[H-].[Na+],,val
US20080280900A1,COC(=O)c1sc2nc[nH]c(=O)c2c1C.O=C(CCl)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>COC(=O)c1sc2ncn(CC(=O)Nc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(=O)c2c1C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04766121,COc1ccc(Br)cn1.COc1ccc(OCc2ccccc2)cc1C=O>>COc1ccc(C(O)c2cc(OCc3ccccc3)ccc2OC)cn1,,C1CCOC1,CCCCCC,CCOCC,[Li]CCCC,val
US20050130997A1,COC(=O)C#CC(=O)OC.NCCc1ccccc1Cl.ON=C(Cl)c1cccs1>>O=C(O)c1nc(-c2cccs2)n(CCc2ccccc2Cl)c(=O)c1O,,ClC(Cl)Cl,,C1CCOC1,CCN(CC)CC,val
US20060264444A1,CC(C)(C)OC(=O)CBr.Cc1[nH]c2c(Br)ccc([N+](=O)[O-])c2c1Oc1ccc(Cl)cc1>>Cc1c(Oc2ccc(Cl)cc2)c2c([N+](=O)[O-])ccc(Br)c2n1CC(=O)OC(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US04317830,BrCC1CCCCCCC1.c1c[nH]cn1>>c1cn(CC2CCCCCCC2)cn1,,CCO,,[Na],,val
US20100216788A1,CC(C)(C)CS(=O)(=O)c1cccc(Oc2ccc(N)cc2Cl)c1.O=C(OCCn1ccc2ncnc(Cl)c21)c1ccccc1>>CC(C)(C)CS(=O)(=O)c1cccc(Oc2ccc(Nc3ncnc4ccn(CCO)c34)cc2Cl)c1,,CC(C)O,,[Na+].[OH-],,val
US07825256B2,CC(C)(C)OC(=O)N(CCCN(CC(=O)O)c1nc(-n2ccnc2)ns1)Cc1ccc2c(c1)OCO2>>O=C(O)CN(CCCNCc1ccc2c(c1)OCO2)c1nc(-n2ccnc2)ns1,,ClCCl,O=C(O)C(F)(F)F,,,val
US04309426,CNC(=S)NN.O=C(CCl)c1ccccc1F>>CNC1=NN=C(c2ccccc2F)CS1.Cl,,CO,,,,val
US04673684,COCCOCOc1c(OC)cc(C=CC(=O)N2CCSC2=S)cc1OC.c1ccc(C(OCCN2CCNCC2)c2ccccc2)cc1>>COCCOCOc1c(OC)cc(C=CC(=O)N2CCN(CCOC(c3ccccc3)c3ccccc3)CC2)cc1OC,,CN(C)C=O,,,,val
US20030125370A1,Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CC(=O)O.NCC(O)CNC1CC1>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CC(=O)NCC(O)CNC1CC1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20090298807A1,CC(C)(C)[Si](C)(C)Cl.CC(C)(CO)c1ccccc1F>>CC(C)(CO[Si](C)(C)C(C)(C)C)c1ccccc1F,,CN(C)C=O,,c1c[nH]cn1,,val
US20080287457A1,CC(C)(C)OC(=O)N1CCC(C(=O)NN)CC1.N#Cc1ncccn1>>CC(C)(C)OC(=O)N1CCC(c2n[nH]c(-c3ncccn3)n2)CC1,,CCCCO,,,,val
US20140200216A1,C=Cc1ccc2cc(NC(=O)OCc3ccccc3)c(C(=O)O)nc2c1>>CCc1ccc2cc(N)c(C(=O)O)nc2c1,[Pd],CO,,[H][H],,val
US20080015199A1,CC(C)(C)OC(=O)Nc1ccc(C(=N)NO)cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)Nc1ccc(-c2noc(C(F)(F)F)n2)cc1,,CCOC(C)=O,O,CCN(C(C)C)C(C)C,ClCCl,val
US04263207,COC(=O)c1ccc2c(c1)Sc1ccccc1NC2=O>>O=C(O)c1ccc2c(c1)Sc1ccccc1NC2=O,,C1CCOC1,,[Na+].[OH-],,val
US20110015232A1,COc1ccc([C@@H](C)N2CCC[C@H]2c2ccnc(-c3cn(C(=O)OC(C)(C)C)c4ccccc34)c2)cc1>>c1ccc2c(-c3cc([C@@H]4CCCN4)ccn3)c[nH]c2c1,,O=C(O)C(F)(F)F,,,,val
US20100292196A1,C=C1CCCC1.CCn1ncc2c(NC3CCCCC3)c(C=NO)cnc21>>CCn1ncc2c(NC3CCCCC3)c(C3=NOC4(CCCC4)C3)cnc21,,C1CCOC1,,[Na+].[O-]Cl,,val
US20040220169A1,C1CSCN1.O=C(NCc1nc2cc(Cl)ccc2[nH]1)c1ccc(C(=O)O)c(Cl)c1>>O=C(NCc1nc2cc(Cl)ccc2[nH]1)c1ccc(C(=O)N2CCSC2)c(Cl)c1,,CS(C)=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US04550981,CCCCCCC[C@@H]1CC[C@@H](C(=O)Oc2ccc(C(=O)Oc3ccc(C=O)cc3)c(Cl)c2)CC1.O=[Cr](=O)=O>>CCCCCCC[C@@H]1CC[C@@H](C(=O)Oc2ccc(C(=O)Oc3ccc(C(=O)O)cc3)c(Cl)c2)CC1,,CC(C)=O,,O=S(=O)(O)O,,val
US06372736B1,CC#N.ClCc1ccncc1.O=C(NC1CCNCC1)[C@@H]1CCCCN1c1nc2ccccc2o1>>N.O=C(NC1CCN(Cc2ccncc2)CC1)[C@@H]1CCCCN1c1nc2ccccc2o1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20130217680A1,C=CCc1ccc2c(c1)COC2=O.CO>>O=C1OCc2cc(CCO)ccc21,,C1CCOC1,,[BH4-].[Na+],,val
US20110142796A1,COC(=O)CNC1CCCC1.CSc1ncc(C=O)c(Cl)n1>>COC(=O)CN(c1nc(SC)ncc1C=O)C1CCCC1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20110071199A1,Fc1cc(CBr)c(F)cc1Br.NC(=O)[C@@H](CC1CC1)NS(=O)(=O)c1ccc(Cl)s1>>NC(=O)[C@@H](CC1CC1)N(Cc1cc(F)c(Br)cc1F)S(=O)(=O)c1ccc(Cl)s1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04771046,CC1C(Sc2ccccc2)=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)N2C(=O)[C@H]([C@@H](C)O)[C@@H]12.O=C(OO)c1cccc(Cl)c1>>CC1C(S(=O)c2ccccc2)=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)N2C(=O)[C@H]([C@@H](C)O)[C@@H]12,,ClCCl,,O=C([O-])O.[Na+],,val
US20150094297A1,CC(C)(C)OC(=O)c1ccc(B(O)O)cc1.Cc1sc(Br)nc1CO[Si](C)(C)C(C)(C)C>>Cc1sc(-c2ccc(C(=O)OC(C)(C)C)cc2)nc1CO[Si](C)(C)C(C)(C)C,,CCO,Cc1ccccc1,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20060111375A1,COc1cc2nccc(Oc3ccc(C)nc3I)c2cc1OC.OB(O)c1ccccc1Cl>>COc1cc2nccc(Oc3ccc(C)nc3-c3ccccc3Cl)c2cc1OC,,O,,Cc1ccccc1,O=C([O-])O.[Na+],val
US05208250,O=C1CNC(=S)N1.O=Cc1cc(Br)c(O)c(Br)c1>>O=C1NC(=S)NC1=Cc1cc(Br)c(O)c(Br)c1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20050209290A1,FC(F)Oc1ccc(C=Cc2nc(CCl)co2)cc1.Oc1ccc(COCCn2ccnn2)cc1>>FC(F)Oc1ccc(/C=C/c2nc(COc3ccc(COCCn4ccnn4)cc3)co2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US05849757,CCOC(=O)c1cn([C@@H]2C[C@@H]2F)c2c(C)c(F)c(F)c([N+](=O)[O-])c2c1=O>>CCOC(=O)c1cn([C@@H]2C[C@@H]2F)c2c(C)c(F)c(F)c(N)c2c1=O,[Ni],C1COCCO1,,CO,,val
US20080255160A1,Cc1ccc(S(=O)(=O)Cl)cc1.Cn1cnc2c(c(O)cc(=O)n2C)c1=O>>Cc1ccc(S(=O)(=O)Oc2cc(=O)n(C)c3ncn(C)c(=O)c23)cc1,,CC#N,,CCN(CC)CC,,val
US20030232828A1,CN(C)CCCl.c1ccc2[nH]ccc2c1>>CN(C)CCn1ccc2ccccc21,,CN(C)C=O,,Cl,[H-].[Na+],val
US20120270865A2,CCOC(=O)CCNC(=O)c1ccc(NC(c2oc3ccc(C#N)cc3c2C)C2CCCCC2)cc1>>Cc1c(C(Nc2ccc(C(=O)NCCC(=O)O)cc2)C2CCCCC2)oc2ccc(C#N)cc12,,CCO,,C1CCOC1,[Li+].[OH-],val
US20140179934A1,CCCC[Sn](Cl)(CCCC)CCCC.c1coc(-c2ccco2)c1>>CCCC[Sn](CCCC)(CCCC)C1(c2ccco2)CC=CO1,,C1CCOC1,,[Li]CCCC,,val
US20070213315A1,CC(=O)Cl.CC(C)(C)OC(=O)N1CCC2(CC[C@H](N)c3ccccc32)CC1>>CC(=O)N[C@H]1CCC2(CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21,,CC#N,,CCN(CC)CC,,val
US05955607,CC1(C)CC(=O)c2cc(F)ccc2O1.NO>>CC1(C)CC(=NO)c2cc(F)ccc2O1,,CO,c1ccncc1,Cl,,val
US20100112090A1,CCOC(=O)c1cc(C)c2[nH]c(=O)n(-c3cc(S(=O)(=O)N4CCCCc5ccccc54)ccc3Cl)c2n1>>Cc1cc(CO)nc2c1[nH]c(=O)n2-c1cc(S(=O)(=O)N2CCCCc3ccccc32)ccc1Cl,,C1CCOC1,,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US20040158067A1,CCOC(=O)Cl.N[C@H]1CCCc2ccccc21>>CCOC(=O)N[C@H]1CCCc2ccccc21,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US05157027,CC(C)=CCC[C@H](C)CCO.II>>CC(C)=CCC[C@H](C)CCI,,C1CCOC1,CCCCCC,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US07282500B2,NCCN1CCOCC1.O=C(O)c1nc(-c2ccc3c(c2)CCC3=O)c(-c2ccncc2)[nH]1.On1nnc2ccccc21>>O=C(NCCN1CCOCC1)c1nc(-c2ccc3c(c2)CCC3=NO)c(-c2ccncc2)[nH]1,,CN(C)C=O,ClCCl,,,val
US05541324,COC(=O)CCC(Nc1ccccc1[N+](=O)[O-])C(=O)OC>>O=C1Nc2ccccc2N2C(=O)CCC12,[Pd],CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110046171A1,C1CCC2(C1)CN=NC2.CSC(=NS(=O)(=O)c1ccc(C(O[SiH2]C(C)(C)C)(c2ccccc2)c2ccccc2)cc1)SC>>CSC(=NS(=O)(=O)c1ccc(C(O[SiH2]C(C)(C)C)(c2ccccc2)c2ccccc2)cc1)N1CC2(C=N1)CCCC2,,c1ccncc1,,,,val
US20140309231A1,CCO.CCOC(OCC)OCC.O=Cc1ccc(Br)nc1>>CCOC(OCC)c1ccc(Br)nc1,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04537621,CCS.O=[N+]([O-])c1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1SCl>>CCSSc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],,CCOCC,,CCN(CC)CC,,val
US20020035272A1,COCCOCOc1c(-c2ccccc2)cc(C(=O)OC)cc1-c1ccccc1>>COC(=O)c1cc(-c2ccccc2)c(O)c(-c2ccccc2)c1,,CCOCC,ClCCl,O=C(O)C(F)(F)F,,val
US05504237,CC#CN.CCCCCCCCC(=O)Cl>>CC#CNC(=O)CCCCCCCC,,CCN(CC)CC,,,,val
US20150329506A1,Cc1noc(C)c1[C@@H]1C[C@@](C)(c2cc(-c3cnc(F)nc3)c(F)cc2F)N=C(NC(=O)OC(C)(C)C)S1>>Cc1noc(C)c1[C@@H]1C[C@@](C)(c2cc(-c3cnc(F)nc3)c(F)cc2F)N=C(N)S1,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,[Na+].[OH-],val
US04259504,COC(OC)N(C)C.Nc1ccc(-c2ncnn2-c2ccc(F)cc2)cc1>>CN(C)C=Nc1ccc(-c2ncnn2-c2ccc(F)cc2)cc1,,CO,,,,val
US20130123512A1,Cc1cc(Br)ccn1.OB(O)c1ccc(F)c(C(F)(F)F)c1>>Cc1cc(-c2ccc(F)c(C(F)(F)F)c2)ccn1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20120214762A1,CC1(C)OCC(CO)O1.Nc1nccc(-n2c(C(Cl)(Cl)Cl)nc3ccc(Br)cc32)n1>>CC1(C)OCC(COc2nc3ccc(Br)cc3n2-c2ccnc(N)n2)O1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070173501A1,CC1(C)O/C(=C2/C(=O)Nc3ccc(F)cc32)C=C1Br.OB(O)c1ccc(F)nc1>>CC1(C)O/C(=C2/C(=O)Nc3ccc(F)cc32)C=C1c1ccc(F)nc1,,C1CCOC1,O,O=C([O-])[O-].[K+].[K+],,val
US20140288045A1,C=CC(=O)N1CCN(C(=O)c2cc(-c3ccccc3Cl)c(Cl)cc2OC)CC1>>C=CC(=O)N1CCN(C(=O)c2cc(-c3ccccc3Cl)c(Cl)cc2O)CC1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20080070920A1,COc1nc(Cl)c(C(C)C)c(OC)n1.Cc1cc(Br)cc(CC#N)c1>>COc1nc(OC)c(C(C)C)c(C(C#N)c2cc(C)cc(Br)c2)n1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20110306592A1,Cn1nc(NCC(=O)NC2CN(C3CCC(C(=O)O)CC3)C2)c2cc(C(F)(F)F)ccc21.N>>Cn1nc(NCC(=O)NC2CN(C3CCC(C(N)=O)CC3)C2)c2cc(C(F)(F)F)ccc21,,C1CCOC1,ClCCl,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20080139562A1,CC(CC1CCCC1)(C(=O)O)c1ccc(S(C)(=O)=O)cc1>>CS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)O)cc1,,CO,,[Na+].[OH-],,val
US05162334,CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(OCC=Cc4ccccc4)C(O)C3)C(C)CCC1=O)C(C)CC2OC>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(OCCCc4ccccc4)C(O)C3)C(C)CCC1=O)C(C)CC2OC,[Rh],,,[H][H],,val
US20050148627A1,CCOC(=O)C1=Cc2ccc(I)cc2OC1C(F)(F)F.OB(O)c1cccnc1.[C]=O>>CCOC(=O)C1=Cc2ccc(C(=O)c3cccnc3)cc2OC1C(F)(F)F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20100234395A1,COC(=O)Cn1c(C2CCN(C(=O)OC(C)(C)C)CC2)nc(-c2ccc(OC)cc2)c1-c1ccc(OC)cc1>>COC(=O)Cn1c(C2CCNCC2)nc(-c2ccc(OC)cc2)c1-c1ccc(OC)cc1,,CO,Cl,,,val
US20010014740A1,CCCCCCN1CCc2c(C)cc(C)c(N)c21.CCCCN=C=O>>CCCCCCN1CCc2c(C)cc(C)c(NC(=O)NCCCC)c21,,ClC(Cl)Cl,,O,,val
US20140057895A1,CC(C)(C)OC(=O)N1CCC(C(Cl)=NO)CC1.N#Cn1nc(Cl)c2ccccc21>>CC(C)(C)OC(=O)N1CCC(c2noc(-n3nc(Cl)c4ccccc43)n2)CC1,,Cc1ccccc1,,O,O=C([O-])O.[Na+],val
US20090275753A1,CC(=O)N(CC1C([N+](=O)[O-])=C(C)C(C)=C2OC(C)(C)CC21)c1ccc(-c2ccn(C3CCCCO3)n2)cc1>>CC(=O)N(CC1C(N)=C(C)C(C)=C2OC(C)(C)CC21)c1ccc(-c2ccn[nH]2)cc1,,CO,,Cl,[Na+].[OH-],val
US20130096135A1,C[C@@H](O)CCl.O=C(Nc1ccc(Oc2ccnc3cc(-c4ccc(CN5CCNCC5)cn4)sc23)c(F)c1)NC1CC1>>C[C@@H](O)CN1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc(NC(=O)NC6CC6)cc5F)c4s3)nc2)CC1,,CCOC(C)=O,CS(C)=O,CCN(C(C)C)C(C)C,,val
US04922022,NCCc1ccccc1.O=C(O)CCC1CCC(=O)O1>>O=C(CCC1CCC(=O)O1)NCCc1ccccc1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20060135773A1,BrCc1ccc(I)cc1.CC(C)(C)OC(=O)NCc1ccc(I)cc1>>CC(C)(C)OC(=O)N(Cc1ccc(I)cc1)Cc1ccc(I)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20070287751A1,N#Cc1cccc(COc2ccc(C=O)cc2)c1.OO>>NC(=O)c1cccc(COc2ccc(C=O)cc2)c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05488066,C=C(Cc1ccccc1)C(=O)[O-]>>C=C(Cc1ccccc1)C(=O)O,,CO,,[K+].[OH-],,val
US07820665B2,Brc1ccc2nccn2c1.CC1(C)OB(c2cnc(Cl)c(NS(=O)(=O)c3ccc(F)cc3)c2)OC1(C)C.COc1nc(N)nc2[nH]ccc12>>Nc1cn2cc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)ccc2n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CS(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20060205942A1,COc1ccccc1Br.O=S(=O)(O)Cl>>COc1ccc(S(=O)(=O)Cl)cc1Br,,ClC(Cl)Cl,,,,val
US20060199851A1,CC(C)(C)OC(=O)N[C@H](CO)Cc1ccccc1>>CC(C)(C)OC(=O)N1C[C@@H]1Cc1ccccc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130184280A1,Nc1ncncc1-c1nc(-c2cccc([N+](=O)[O-])c2)cs1>>Nc1cccc(-c2csc(-c3cncnc3N)n2)c1,[Pd],CO,,,,val
US20040077726A1,COC(=O)C=Cc1cccc(S(=O)(=O)N(C)c2ccccc2)c1>>CN(c1ccccc1)S(=O)(=O)c1cccc(C=CC(=O)O)c1,,CO,,[Na+].[OH-],,val
US07589127B2,C1N2CN3CN1CN(C2)C3.CC(C)(C)c1cc(O)c(CN)c(C(C)(C)C)c1>>CNCc1c(O)cc(C(C)(C)C)cc1C(C)(C)C,,CC(=O)O,O,Cl,Cl,val
US20090298836A1,CCOC(=O)Cc1cc(-c2nnc(CC[C@H](Cc3ccc(C(F)(F)F)nc3)NC(=O)OC(C)(C)C)s2)ccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)N[C@H](CCc1nnc(-c2ccc3c(c2)CC(=O)N3)s1)Cc1ccc(C(F)(F)F)nc1,[Fe],CCO,O,Cl,O=C([O-])O.[Na+],val
US04772600,CCOC(=O)CNc1nc(Cl)ccc1[N+](=O)[O-].O=C(Cl)c1ccc(Cl)cc1>>CCOC(=O)CNc1nc(Cl)ccc1NC(=O)c1ccc(Cl)cc1,O=[Pt]=O,C1CCOC1,,CCN(CC)CC,,val
US20160039879A1,CCC[C@H](CCSC(C)=O)C(=O)OCC>>CCC[C@H](CCS)C(=O)OCC,,CCO,,[Li+].[OH-],,val
US04221914,CC(=O)OC(C)=O.Cc1ccc(S(=O)(=O)n2cncc2CO)cc1>>CC(=O)OCc1cncn1S(=O)(=O)c1ccc(C)cc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20040242572A1,CC(=O)OC(C)=O.Nc1cc(-c2ccc(C(F)(F)F)cc2)ccc1C(=O)NCCc1ccc(CN2CCCC2)cc1>>Cc1nc2cc(-c3ccc(C(F)(F)F)cc3)ccc2c(=O)n1CCc1ccc(CN2CCCC2)cc1,,CC(=O)O,O,[Na+].[OH-],,val
US20120302540A1,CC(C)(C)OC(=O)N1CCCC2(C1)C(=O)NC2c1ccc(F)cc1.CI>>CN1C(=O)C2(CCCN(C(=O)OC(C)(C)C)C2)C1c1ccc(F)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20080318943A1,CCCC[Sn](Cl)(CCCC)CCCC.N#Cc1cc(F)ccc1Br>>CCCC[Sn](CCCC)(CCCC)c1cc(F)ccc1C#N,,CCOCC,,[Li]CCCC,[Cl-].[NH4+],val
US20160168100A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1cc(C)c(/C=C/C2NCCc3cc(OCc4ccccc4)c(OC)cc32)cc1OCc1ccccc1>>COc1cc(C)c(/C=C/C2c3cc(OC)c(OCc4ccccc4)cc3CCN2C(=O)OC(C)(C)C)cc1OCc1ccccc1,,ClCCl,,,,val
US03952001,C=CCN(CC=C)C(=O)Cl.CS(=O)(=O)c1nc[nH]n1>>C=CCN(CC=C)C(=O)n1cnc(S(C)(=O)=O)n1,,CCN(CC)CC,,C1CCOC1,,val
US20140249126A1,C1CCNC1.COc1ccc(COc2cn(C)c3ccc(C=O)cc3c2=O)cc1>>COc1ccc(COc2cn(C)c3ccc(CN4CCCC4)cc3c2=O)cc1,CC(=O)O,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04695575,Fc1ccc(Cn2c(Cl)nc3ccccc32)cc1.NC(N)=S>>Fc1ccc(Cn2c(S)nc3ccccc32)cc1,,CCO,,,,val
US20090326002A1,N#Cc1cc(F)cc(S(=O)(=O)c2sc3c(ccc[n+]3[O-])c2Br)c1.O=[N+]([O-])O>>N#Cc1cc(F)cc(S(=O)(=O)c2sc3c(cc([N+](=O)[O-])c[n+]3[O-])c2Br)c1,,CC(=O)O,,CCOCC,,val
US20100010053A1,CC(C)Oc1ccc(-c2nc(-c3cccc4c(CCC(=O)O)cn(C)c34)no2)cc1Cl>>CC(C)Oc1ccc(-c2nc(-c3cccc4c(CCCO)cn(C)c34)no2)cc1Cl,,C1CCOC1,,[BH4-].[Na+],,val
US20050054631A1,O=C1N(c2ccccc2)c2ncccc2C1(Br)Br>>O=C1Cc2cccnc2N1c1ccccc1,[Pd],CCO,,,,val
US05633262,C=CC#N.CCOC(=O)CN>>CCOC(=O)CNCCC#N,,O,,Cl,[K+].[OH-],val
US20040106615A1,Fc1cnc(Cl)nc1Cl.O=C(O)c1ccc(B(O)O)cc1>>O=C(O)c1ccc(-c2nc(Cl)ncc2F)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20080207598A1,NC(=S)c1cn(CC2CCOCC2)c2c(Cl)cccc12.O=C(CCl)CCl>>ClCc1csc(-c2cn(CC3CCOCC3)c3c(Cl)cccc23)n1,,Cc1ccccc1,,,,val
US05045558,CCCC(c1ccc(C=O)cc1)n1ccnc1.NO>>CCCC(c1ccc(C=NO)cc1)n1ccnc1,,c1ccncc1,,Cl,,val
US20100120741A1,O=P(Cl)(Cl)Cl.O=[N+]([O-])c1cnc2ccc(Cl)cc2c1O>>O=[N+]([O-])c1cnc2ccc(Cl)cc2c1Cl,,CC#N,,CCN(C(C)C)C(C)C,,val
US20110212939A1,CC(C)c1noc(N2CCC(CCCOS(C)(=O)=O)CC2)n1.Cc1nc(-c2ccc(O)cc2)no1>>Cc1nc(-c2ccc(OCCCC3CCN(c4nc(C(C)C)no4)CC3)cc2)no1,,CS(C)=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US04820834,CN1C(=O)C(N)N=C(c2ccccc2)c2ccccc21.O=C=NCc1ccccc1>>CN1C(=O)C(NC(=O)NCc2ccccc2)N=C(c2ccccc2)c2ccccc21,,C1CCOC1,,,,val
US20050182040A1,Cl.NC(=O)c1ccc(NC2CCN(Cc3ccccc3)CC2)cc1>>Cl.NC(=O)c1ccc(NC2CCN(Cc3ccccc3)CC2)cc1,,C1CCOC1,,CCOCC,,val
US05244890,CC(=O)Oc1cnc(C(=O)O)cc1OC(C)=O.ClP(Cl)(Cl)(Cl)Cl>>CC(=O)Oc1cnc(C(=O)Cl)cc1OC(C)=O.Cl,,ClCCl,,CC(C)OC(C)C,,val
US20090253736A1,C#CC(C)(C)C.OCCNc1cnc(Cl)cc1I>>CC(C)(C)C#Cc1cc(Cl)ncc1NCCO,[Cu]I,CCN(CC)CC,,,,val
US05273975,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)NC1Cc2cccc3[nH]c(=O)n(c23)C1>>N[C@@H](Cc1ccccc1)C(=O)NC1Cc2cccc3[nH]c(=O)n(c23)C1,,Cl,,,,val
US06211234B1,CCOC(=O)C(=O)CC(=O)c1ccc(OCc2ccsc2)cc1OC(C)c1ccccc1C>>Cc1ccccc1C(C)Oc1cc(OCc2ccsc2)ccc1C(=O)CC(=O)C(=O)O,,[K+],[OH-],,,val
US20050288354A1,COC(=O)CCc1c[nH]c2ccc(OC)cc12.COc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)CCc1cn(S(=O)(=O)c2ccc(OC)cc2)c2ccc(OC)cc12,,CN(C)C=O,,[H-].[Na+],,val
US20100267728A1,CC[C@H](CO)n1cnc2cc3c(=O)n([C@H](CC)Cn4ncnn4)cnc3cc2c1=O.COC(=O)c1nc[nH]n1>>CC[C@H](Cn1cnnc1)n1cnc2cc3c(=O)n([C@H](CC)Cn4ncnn4)cnc3cc2c1=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05547983,COC(=O)c1ccc2cc(-c3ccc(CO)c(C45CC6CC(CC(C6)C4)C5)c3)ccc2c1>>O=C(O)c1ccc2cc(-c3ccc(CO)c(C45CC6CC(CC(C6)C4)C5)c3)ccc2c1,,CO,,[Na+].[OH-],,val
US20030078271A1,Cc1ccc(Nc2cc(N(C)C)nc(NC(=O)Cc3ccccc3)n2)cc1>>Cc1ccc(Nc2cc(N(C)C)nc(NCCc3ccccc3)n2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090149501A1,CS(=O)(=O)Cl.OCCc1cccnc1>>CS(=O)(=O)OCCc1cccnc1,,C1CCOC1,,CCN(CC)CC,,val
US20080255133A1,CC(C)N=C(NC(C)C)OC(C)(C)C.O=C(O)c1nnc(Cl)cc1Nc1ccc(Br)cc1F>>CC(C)(C)OC(=O)c1nnc(Cl)cc1Nc1ccc(Br)cc1F,,C1CCOC1,CCOC(C)=O,,,val
US20050059651A1,COc1cc(N)ccc1OCCN1CCCC1.O=C(O)c1cc(Cl)ccc1[N+](=O)[O-]>>COc1cc(NC(=O)c2cc(Cl)ccc2[N+](=O)[O-])ccc1OCCN1CCCC1,CN(C)C=O,ClCCl,,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20040152704A1,CC(=O)C=O.Nc1ccc(Br)cc1N>>Cc1cnc2cc(Br)ccc2n1,,CC#N,,,,val
US20140329853A1,CCOC(=O)C1(c2nc3c(OC)cccn3n2)CC1.O=C1CCC(=O)N1Br>>CCOC(=O)C1(c2nc3c(OC)ccc(Br)n3n2)CC1,,CC#N,CCOC(C)=O,,,val
US20100160303A1,O=C(n1ccnc1)n1ccnc1.Oc1ccc(Br)cc1CNc1ccccc1>>O=C1Oc2ccc(Br)cc2CN1c1ccccc1,CN(C)c1ccncc1,ClCCl,,,,val
US20130178486A1,COc1ccc(CCl)cc1.Clc1cc2nc[nH]c2cn1>>COc1ccc(Cn2cnc3cc(Cl)ncc32)cc1,,C1CCOC1,,O,[H-].[Na+],val
US20120028938A1,CC(C)(C)S(N)(=O)=O.Cc1nn(Cc2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2)c(C)c1CC(=O)O>>Cc1nn(Cc2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2)c(C)c1CC(=O)NS(=O)(=O)C(C)(C)C,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150158847A1,CCOC(=O)Nc1nc2cc(-c3cnn(C)c3)cnc2n1Cc1ccc(OCc2ccc(OC)cc2)c(OC)c1>>CCOC(=O)Nc1nc2cc(-c3cnn(C)c3)cnc2n1Cc1ccc(O)c(OC)c1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20150274777A1,CCCCC(NC(=O)OC(C)(C)C)[C@H](O)C(=O)O.C[C@@H](N)c1ccccc1>>CCCC[C@H](NC(=O)OC(C)(C)C)C(O)C(=O)N[C@H](C)c1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04708953,O=C(NC(Cl)C(Cl)(Cl)Cl)c1ccccc1O.OCC(F)(F)F>>O=C(NC(OCC(F)(F)F)C(Cl)(Cl)Cl)c1ccccc1O,,Cc1ccccc1,,c1ccncc1,,val
US20110306587A1,Clc1ccc2ccccc2n1.Oc1ccccc1-c1nccnc1C1CNC1>>Oc1ccccc1-c1nccnc1C1CN(c2ccc3ccccc3n2)C1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US04840971,CCOc1ccc(C(CO)C(F)(F)F)cc1.Fc1ccc(CBr)cc1Oc1ccccc1>>CCOc1ccc(C(COCc2ccc(F)c(Oc3ccccc3)c2)C(F)(F)F)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100160322A1,CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(Cl)c([N+](=O)[O-])c4)c(Oc4cc5cc[nH]c5cc4F)c3)CC2)=C(c2ccc(Cl)cc2)C1.NC[C@@H]1CC[C@@H](O)CC1>>CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(NC[C@@H]5CC[C@@H](O)CC5)c([N+](=O)[O-])c4)c(Oc4cc5cc[nH]c5cc4F)c3)CC2)=C(c2ccc(Cl)cc2)C1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20010007675A1,CCCCCCCCCCCCNC(=O)n1ccnc1.NCC(O)CO>>CCCCCCCCCCCCNC(=O)NCC(O)CO,,CO,,,,val
US20100152160A1,CC(C)(C)OC(=O)N1CC(C(=O)N2CCC(C#N)(Cc3ccc(F)cc3)CC2)Oc2cc(O)c(Cl)cc21.FC(F)Cl>>CC(C)(C)OC(=O)N1CC(C(=O)N2CCC(C#N)(Cc3ccc(F)cc3)CC2)Oc2cc(OC(F)F)c(Cl)cc21,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20020052371A1,Nc1ccc(C(=O)c2ccccc2)cc1.O=C(Cl)Oc1ccccc1>>O=C(Nc1ccc(C(=O)c2ccccc2)cc1)Oc1ccccc1,,c1ccncc1,,O,,val
US20060100431A1,CC(C)C[C@H](NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(=O)N1[C@H]2[C@@H](CN1C(=O)OC(C)(C)C)N(C(=O)c1cccc(S(C)(=O)=O)c1)C[C@@H]2O>>CC(C)C[C@H](NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(=O)N1[C@@H]2C(=O)CN(C(=O)c3cccc(S(C)(=O)=O)c3)[C@@H]2CN1C(=O)OC(C)(C)C,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20120277229A1,O=C(Nc1ccc2c(c1)c(-c1nc3cc(N4CCOCC4)ccc3[nH]1)nn2C1CCCCO1)C1CCC(F)(F)CC1>>O=C(Nc1ccc2[nH]nc(-c3nc4cc(N5CCOCC5)ccc4[nH]3)c2c1)C1CCC(F)(F)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160060257A1,COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(S(=O)(=O)NC(=O)OCC4COC(C)(C)O4)CC3)cc12>>COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(S(=O)(=O)NC(=O)OCC(O)CO)CC3)cc12,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20110312954A1,CC(C)(C)OC(=O)N1C[C@H](N=[N+]=[N-])C[C@@H]1CO>>CC(C)(C)OC(=O)N1C[C@H](N)C[C@@H]1CO,[Pd],CO,,[H][H],,val
US20100130497A1,CCC(Br)CC.COc1cc(C=O)ccc1O>>CCC(CC)Oc1ccc(C=O)cc1OC,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20090069340A1,CCOC(=O)CC(C)=O.NNc1ccccc1>>Cc1cc(=O)n(-c2ccccc2)[nH]1,,Cc1ccccc1,,,,val
US04554012,CNc1cccc(OC)n1.O=C(Cl)Oc1ccc(C(F)(F)F)cc1>>COc1cccc(N(C)C(=O)Oc2ccc(C(F)(F)F)cc2)n1,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060041146A1,CCSc1csc(NC(=O)OC(C)(C)C)n1>>CCSc1csc(N)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100113502A1,CC1CCN(C(=O)c2ccc3c(c2)c2c(n3CC3CC3)CCN(C(=O)OC(C)(C)C)C2)CC1.Cl>>CC1CCN(C(=O)c2ccc3c(c2)c2c(n3CC3CC3)CCNC2)CC1.Cl,,CCOCC,CO,,,val
US09388155B1,CC(C)=CCBr.O=c1ccc2cc(O)ccc2o1>>CC(C)=CCOc1ccc2oc(=O)ccc2c1,,CN(C)C=O,,[H-].[Na+],,val
US05378720,CC(C)c1cc(O)cc2c1C(=O)NS2(=O)=O.ClCSc1ccccc1>>CC(C)c1cc(O)cc2c1C(=O)N(CSc1ccccc1)S2(=O)=O,,CO,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030225081A1,CC(C)(C)[Si](C)(C)OCCBr.O=C1C(c2cccc(O)c2)CC(c2ccccn2)=NN1c1ccccc1Br>>O=c1c(-c2cccc(OCCO)c2)cc(-c2ccccn2)nn1-c1ccccc1Br,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20150005245A1,CC(=O)SCCOCCOCCOCCOCCOCC[N-]C(=O)C(F)(F)F.Cl>>Cl.NCCOCCOCCOCCOCCOCCS,,O,,CO,C[O-].[Na+],val
US20130116233A1,CC(C)(C)N.O=C(O)c1ccccc1Cl>>CC(C)(C)NC(=O)c1ccccc1Cl,,C1CCOC1,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US06329338B1,CCN(CCCOS(=O)(=O)c1ccc(C)cc1)C(=O)OCc1ccccc1.[I-]>>CCN(CCCI)C(=O)OCc1ccccc1,,CC(C)=O,,CCOC(C)=O,O,val
US20130178460A1,Nc1ccc2ncccc2n1.O=C(O)c1csc2cnc(Cl)nc12>>O=C(Nc1ccc2ncccc2n1)c1csc2cnc(Cl)nc12,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080004271A1,CCOC(=O)CC#N.N=CN.O=Cc1cccc(NC(=O)Nc2ccc(C(F)(F)F)cc2)c1>>N#Cc1c(O)ncnc1-c1cccc(NC(=O)Nc2ccc(C(F)(F)F)cc2)c1,C1CCNCC1,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20150126490A1,CC(C)(C)OP(=O)(OC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)[C@@H](F)C3)cnc2N)cc1F)c1cc(F)cc(I)c1)OC(C)(C)C>>Nc1ncc([C@H]2CC[C@H](O)[C@@H](F)C2)nc1-c1ccc(C(=O)N[C@H](COP(=O)(O)O)c2cc(F)cc(I)c2)c(F)c1,,CO,,C1COCCO1,Cl,val
US20030092677A1,CC(C)(C)OC(=O)Nc1ccc(-c2cc(F)ccc2F)cc1NC(=O)CC(=O)c1cccc(C#N)c1>>N#Cc1cccc(C2=Nc3ccc(-c4cc(F)ccc4F)cc3NC(=O)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090298818A1,C1CCOC1.CCN(CC)CC.NCc1ccccc1>>c1ccc(CN2Cc3ccccc3C2)cc1,,CCN(CC)CC,,,,val
US20140194431A1,CCOC(C)=O.N#CC1(c2cccc3ccccc23)CCCC1>>O=CC1(c2cccc3ccccc23)CCCC1,,CCCCCC,ClCCl,CC(C)C[Al+]CC(C)C.[H-],,val
US20050020593A1,CC(C)(C)OC(=O)N1CCN(c2cccc(CO)c2)CC1.Cl>>Cl.OCc1cccc(N2CCNCC2)c1,,C1COCCO1,,,,val
US20080274517A1,CC(C)=CC(O)(C(=O)O)C(F)(F)F.Fc1ccc2c(c1)CCO2>>CC(C)(CC(O)(C(=O)O)C(F)(F)F)c1cc(F)cc2c1OCC2,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20060019965A1,COC(OC)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1>>O=Cc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090131433A1,C1CCNC1.O=Cc1c(F)cc(O)cc1Cl>>Oc1cc(F)c(CN2CCCC2)c(Cl)c1,,ClCCl,O,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04166852,CCN.CSc1c(Cl)nc(Cl)nc1Cl>>CCNc1nc(Cl)c(SC)c(Cl)n1,,CCC(C)=O,,[Na+].[OH-],,val
US20090233897A1,CCN(CC)S(F)(F)F.CN(c1cccnc1)c1ncccc1C(O)C(c1cccnc1)c1cccnc1>>CN(c1cccnc1)c1ncccc1C(F)C(c1cccnc1)c1cccnc1,,ClCCl,,,,val
US20100286152A1,CN(C)C=O.Cc1cc(F)cc(Br)c1>>Cc1cc(F)ccc1C=O,,C1CCOC1,,[Li]CCCC,,val
US20070191364A1,CC(C)(C)OC(=O)N1CCC(NC2CCCCC2)CC1.CCOC(=O)C=O>>CCOC(=O)CN(C1CCCCC1)C1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140315894A1,COc1ccc(C2=NN(c3ccccc3)C(=O)C2)cc1.COc1ccc(C=O)cc1.N#CCC#N>>COc1ccc(-c2nn(-c3ccccc3)c3c2C(c2ccc(OC)cc2)C(C#N)=C(N)O3)cc1,,CCO,,CCN(CC)CC,,val
US05847164,CCCc1cc(=O)oc2c(C(=O)CC)c(O)c3c(c12)OC(C)(C)C=C3.CCOC(C)OCC>>CCCc1cc(=O)oc2c3c(c4c(c12)OC(C)(C)C=C4)O[C@H](C)[C@@H](C)C3=O,,CCOC(C)=O,,O=C(O)C(F)(F)F,,val
US08703100B2,COCCOCCOCCOCCCNc1nc(C(=O)NCC2COC(C)(C)O2)c(NCCCOCCOCCOCCOC)nc1C(=O)NCC1COC(C)(C)O1>>COCCOCCOCCOCCCNc1nc(C(=O)NCC(O)CO)c(NCCCOCCOCCOCCOC)nc1C(=O)NCC(O)CO,,C1CCOC1,,Cl,,val
US05925152,NCc1ccco1.O=C(Cl)c1ccco1>>O=C(NCc1ccco1)c1ccco1,,CCCCCC,CCOC(C)=O,CCN(CC)CC,ClCCl,val
US20150266874A1,CC(C)N.C[Si](C)(C)CCOCn1cc(C(=O)O)c(-c2nc(-c3ccccc3)cs2)n1>>CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)nc1-c1nc(-c2ccccc2)cs1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05463125,CCC(=O)c1ccccc1.O.[C-]#N>>CCC(O)(C(N)=O)c1ccccc1,,CCOCC,,Cl,,val
US20120157430A1,COc1c(C(C)Nc2ncnc3[nH]cnc23)cc(Cl)c(C)c1C1CNC1.CS(=O)(=O)Cl.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F>>COc1c(C(C)Nc2ncnc3[nH]cnc23)cc(Cl)c(C)c1C1CN(S(C)(=O)=O)C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100216813A1,COC(=O)c1ccc(Cl)c(CN(c2ccc(C#N)c(Cl)c2)[C@H]2CCN(S(C)(=O)=O)C2)c1>>CS(=O)(=O)N1CC[C@H](N(Cc2cc(C(=O)O)ccc2Cl)c2ccc(C#N)c(Cl)c2)C1,,C1CCOC1,,[Na+].[OH-],,val
US20070225267A1,CC(C)CC(=O)CCC(=O)O.O=C(Cl)OCc1ccccc1>>CC(C)CC(=O)CCC(=O)OCc1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,[Cl-].[NH4+],val
US20100292208A1,COC(=O)c1cc2ccc(O)cc2[nH]1.Clc1nc2ccccc2s1>>COC(=O)c1cc2ccc(Oc3nc4ccccc4s3)cc2[nH]1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050277652A1,C1CCNC1.Nc1cc(Oc2ccc([N+](=O)[O-])cc2F)ncn1.O=C(Cl)Oc1ccccc1>>O=C(Nc1cc(Oc2ccc([N+](=O)[O-])cc2F)ncn1)N1CCCC1,,C1CCOC1,,CCN(CC)CC,,val
US20010004669A1,CN1CCN(c2cccc3ccc(N)cc23)CC1.O=[N+]([O-])c1cccnc1Cl>>CN1CCN(c2cccc3ccc(Nc4ncccc4[N+](=O)[O-])cc23)CC1,CN(C)c1ccncc1,CN(C)C=O,,,,val
US06197766B1,O=C1COC(c2cccc(C(F)(F)F)c2)=NN1C(=O)Nc1ccc(C(F)(F)F)cc1>>O=C(Nc1ccc(C(F)(F)F)cc1)N1N=C(c2cccc(C(F)(F)F)c2)OCC1O,,CO,ClCCl,[BH4-].[Na+],,val
US20150175572A1,CNc1ncc(-c2cc(OC(C)C)c(C)c3c2OCCN(Cc2c(C)cc(C)nc2OCc2ccccc2)C3=O)cn1>>CNc1ncc(-c2cc(OC(C)C)c(C)c3c2OCCN(Cc2c(C)cc(C)[nH]c2=O)C3=O)cn1,,C1COCCO1,ClCCl,Cl,,val
US20100298340A1,CCc1nc(NC(=N)N)sc1-c1ccc([N+](=O)[O-])cc1>>CCc1nc(NC(=N)N)sc1-c1ccc(N)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US20110028492A1,Cc1ncc(NCC2CCOCC2)nc1-c1cc(F)ncc1Cl.N[C@H]1CC[C@H](N)CC1>>Cc1ncc(NCC2CCOCC2)nc1-c1cc(N[C@@H]2CC[C@@H](N)CC2)ncc1Cl,,CS(C)=O,,,,val
US06194611B1,CCS(=O)(=O)N[C@H](C(=O)NCCc1ccc(OCc2ccccc2)c(OC)c1)C(C)C>>CCS(=O)(=O)N[C@H](C(=O)NCCc1ccc(O)c(OC)c1)C(C)C,[Pd],C1CCOC1,,[H][H],,val
US20110313002A1,COc1cccc2c1CC1=C(O2)C(=O)N([C@@H](CC2CCCCC2)C(=O)O)C1.Nc1ccc(Cl)cn1>>COc1cccc2c1CC1=C(O2)C(=O)N([C@@H](CC2CCCCC2)C(=O)Nc2ccc(Cl)cn2)C1,,ClCCl,O,O=C(Cl)C(=O)Cl,,val
US20120040949A1,CC(C)(C=O)c1cc(F)c2c(=O)[nH]ccc2c1>>CC(C)(CO)c1cc(F)c2c(=O)[nH]ccc2c1,,CO,,[BH4-].[Na+],,val
US20050026976A1,Cc1cccc(N=C=O)c1.Nc1ccc(-c2cccc3c2CNC3=O)cc1>>Cc1cccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2)c1,,C1CCOC1,,CN1CCOCC1,,val
US20100292208A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.[N-]=[N+]=NCc1coc2cc(Oc3nc4ncccc4s3)ccc12>>CC(C)(C)OC(=O)NCc1coc2cc(Oc3nc4ncccc4s3)ccc12,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06218376B1,Cn1cc(C2c3ccc(Cl)cc3C=Cc3sc(Cl)nc32)c(=O)[nH]c1=O.NCc1ccccc1>>Cn1cc(C2c3ccc(Cl)cc3C=Cc3sc(NCc4ccccc4)nc32)c(=O)[nH]c1=O,,C1COCCO1,,CS(C)=O,,val
US20030216379A1,CCOC(=O)c1n[nH]c2c1C(=O)CCC2>>O=C(O)c1n[nH]c2c1C(=O)CCC2,,CO,,[Na+].[OH-],,val
US20090318690A1,CN(C)Cc1c(COc2ccc(C#N)cc2)ccc2c(CCC3CCN(C(=O)OC(C)(C)C)CC3)noc12>>CN(C)Cc1c(COc2ccc(C#N)cc2)ccc2c(CCC3CCNCC3)noc12,,CO,,Cl,,val
US20060178532A1,CC(C)NNC(=O)c1ccccc1.O=C(O)COc1ccccc1Cc1ccccc1>>CC(C)N(NC(=O)c1ccccc1)C(=O)COc1ccccc1Cc1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US05539112,CC(=O)OC(C)=O.Cc1c(F)c(N)c2c(=O)cc(-c3ccc(N)c(F)c3)oc2c1F>>CC(=O)Nc1ccc(-c2cc(=O)c3c(N)c(F)c(C)c(F)c3o2)cc1F,,c1ccncc1,,,,val
US20150011548A1,CC(=O)Nc1cc(N)cc(-n2cccc2)c1.O=[N+]([O-])c1cc(I)ccc1F>>CC(=O)Nc1cc(Nc2ccc(I)cc2[N+](=O)[O-])cc(-n2cccc2)c1,,CN(C)C=O,,[F-].[K+],,val
US20050101587A9,COC(OC)N(C)C.Cc1ccc(Cl)cc1[N+](=O)[O-]>>COC(Cc1ccc(Cl)cc1N)OC,,CN(C)C=O,CO,C[Si](C)(C)Cl,,val
US20100190763A1,CCOC(=O)c1ccc(N2CCN(Cc3cnc4c(c3)NC(=O)[C@@H]3CCCN43)CC2)cc1>>O=C(O)c1ccc(N2CCN(Cc3cnc4c(c3)NC(=O)[C@@H]3CCCN43)CC2)cc1,,C1COCCO1,,[Li+].[OH-],,val
US20080070920A1,Cc1cc(C#N)cc(C(=O)c2nc(OCc3ccccc3)nc(OCc3ccccc3)c2C(C)(C)C)c1>>Cc1cc(C#N)cc(C(=O)c2[nH]c(=O)[nH]c(=O)c2C(C)(C)C)c1,[Pd],CCO,,,,val
US20120071489A1,COC(=O)C1CCN(C(=O)C(=O)N2CCN(c3ccccc3C(C)(C)C)CC2)C1>>CC(C)(C)c1ccccc1N1CCN(C(=O)C(=O)N2CCC(C(=O)O)C2)CC1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20150284391A1,CC[C@@H]1C[C@H](C)CCC=C[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2(C)CC2)NC(=O)[C@@H]2C[C@@H](Oc3ncc(OC)c4ccc(F)cc34)CN2C(=O)[C@H]1NC(=O)OC(C)(C)C.Cl>>CC[C@@H]1C[C@H](C)CCC=C[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2(C)CC2)NC(=O)[C@@H]2C[C@@H](Oc3ncc(OC)c4ccc(F)cc34)CN2C(=O)[C@H]1N.Cl,,C1COCCO1,,,,val
US04035363,C=O.COc1ccccc1O.NCCc1ccccc1>>COc1cccc(CNCCc2ccccc2)c1O,,C1COCCO1,,,,val
US20150112075A1,FC(F)(F)CCS.O=C(O)CCBr>>O=C(O)CCSCCC(F)(F)F,,CO,,Cl,[K+].[OH-],val
US20100105604A1,C=CCBr.COC(=O)c1ccc(OCCO)cc1O>>C=CCOc1cc(OCCO)ccc1C(=O)O,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160207930A1,C=CCC1(CC=C)C[C@H]2[C@@H](c3ccc(OC)cc3C)N(C(=O)OC(C)(C)C)CCN2C1=O>>C=CCC1(CC=C)C[C@H]2[C@H](c3ccc(OC)cc3C)NCCN2C1=O,,CO,,Cl,[Na+].[OH-],val
US06008230,O=C1CCC(=O)N1Br.O=c1cc[nH]c2c([N+](=O)[O-])cccc12>>O=c1c(Br)c[nH]c2c([N+](=O)[O-])cccc12,,CN(C)C=O,,O,,val
US20060205774A1,O=C(OCc1ccccc1)N1CC=C(c2ccc(OC3CCN(C4CCC4)CC3)cc2)CC1>>c1cc(C2CCNCC2)ccc1OC1CCN(C2CCC2)CC1,[Pd],CCO,,,,val
US20050245592A1,COc1c(NCC#N)cc(C(C)=O)cc1C(C)(C)C.O=C1CCC(=O)N1Br>>COc1c(NCC#N)cc(C(=O)CBr)cc1C(C)(C)C,,C1CCOC1,,CCN(CC)CC,CCOC(C)=O,val
US05411980,CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1>>CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1,,CO,,ClCCl,,val
US20060189663A1,COCCN1C(=O)C(Nc2ccc(OC)cc2)=C(c2ccccc2)C1=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COCCN1C(=O)C(c2ccccc2)=C(Nc2ccc(OC)cc2)C1=S,,Cc1ccccc1,,,,val
US20070213341A1,C[Si](C)(C)CCOCCl.O=C1Nc2cc(Cl)ccc2/C1=C/c1cccc(Cl)c1>>C[Si](C)(C)CCOCN1C(=O)/C(=C\c2cccc(Cl)c2)c2ccc(Cl)cc21,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20090156583A1,CC(C)N1CCC(O)CC1.O=C1NCCn2c1cc1cc(O)ccc12>>CC(C)N1CCC(Oc2ccc3c(c2)cc2n3CCNC2=O)CC1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20110301200A1,CCOC(=O)C(C)ON=Cc1cc(Br)c(Oc2ccc(O)c(C(=O)c3ccc(Cl)cc3)c2)c(Br)c1>>CCOC(=O)C(C)ON=Cc1cc(Br)c(Oc2ccc(O)c(C(O)c3ccc(Cl)cc3)c2)c(Br)c1,,CCOC(C)=O,CO,[BH4-].[Na+],,val
US20070105900A1,COC(=O)c1nn(C2CCCCO2)cc1N.O=C(Cl)OCc1ccccc1>>O=C(Nc1cn(C2CCCCO2)nc1C(=O)O)OCc1ccccc1,,C1COCCO1,,[Na+].[OH-],,val
US20120302533A1,COc1cc2c(cc1OC)-c1cc(=Nc3c(C)cc(C)cc3C)n(CCN)c(=O)n1CC2>>COc1cc2c(cc1OC)-c1cc(=Nc3ccccc3C)n(CCN)c(=O)n1CC2,,CCO,ClC(Cl)Cl,NN,O,val
US20110124914A1,CCCC(Br)CC[C@H](NC(C)=O)C(=O)OCC>>CCCC(Br)CCC(NC(C)=O)C(=O)O,,CCO,,[Na+].[OH-],,val
US20090186870A1,CCCC[Sn](CCCC)(CCCC)c1cncs1.COC(=O)c1cc(I)ccc1Cl>>COC(=O)c1cc(-c2cncs2)ccc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20060211678A1,Cl.O=c1ccc(N=C(c2ccccc2)c2ccccc2)cn1-c1ccccc1>>Cl.Nc1ccc(=O)n(-c2ccccc2)c1,,C1CCOC1,,,,val
US20070135452A1,CC(=O)O.CC(Cl)Cl.CCC=O.Cc1cc(C)c(Nc2nc3cccc(N)c3s2)c(C)c1>>CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)sc12,CC(=O)O,,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US06207853B1,COC(=O)C(CC(=O)O)=C(C)C>>COC(=O)[C@@H](CC(=O)O)C(C)C,,CO,,,,val
US06576656B1,CCN(CC)CCN1C(=O)C(O)(c2ccc3ccccc3c2)c2c1cc(C#CCN)cc2C(F)(F)F.CCN=C=O>>CCN(CC)CCN1C(=O)C(O)(c2ccc3ccccc3c2)c2c1cc(C#CCN(CC)C(N)=O)cc2C(F)(F)F,,C1CCOC1,,CCN(CC)CC,,val
US05292452,Fc1ccc(-c2ccc(CCl)cn2)cc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Fc1ccc(-c2ccc(C[P+](c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1F.[Cl-],,Cc1ccccc1C,,,,val
US20060106075A1,Clc1ccc(CO[C@@H]2CCC[C@H]2NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>N[C@@H]1CCC[C@H]1OCc1ccc(Cl)cc1,,CCO,ClCCl,Cl,,val
US20060111375A1,CC(=O)Cl.COc1ccc(O)cc1C(C)(C)C>>COc1cc(C(C)=O)c(O)cc1C(C)(C)C,,Cc1ccccc1,ClCCl,c1ccncc1,,val
US20070265249A1,ClCc1nc2cccnc2s1.c1cnc(N2CCNCC2)nc1>>c1cnc(N2CCN(Cc3nc4cccnc4s3)CC2)nc1,,CCOC(C)=O,,,,val
US20080275041A1,CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(Cl)nc2)CC1.Cl.N#Cc1ccc2c(c1)NC(=O)C2>>Cl.N#Cc1ccc2c(-c3ccc(S(=O)(=O)N4CCNCC4)cn3)c(O)[nH]c2c1,,CN1CCCC1=O,CO,CCOCC,[H-].[Na+],val
US20150166512A1,Cc1ccc(Cl)cc1-c1[nH]ccc1C#N.O=C1CCC(=O)N1Br>>Cc1ccc(Cl)cc1-c1[nH]c(Br)cc1C#N,,CC#N,,,,val
US20060148858A1,CCOc1nn(Cc2ccccc2)cc1CCCC=O>>CCOc1nn(Cc2ccccc2)cc1CCCCO,,CCO,,Cl,[BH4-].[Na+],val
US20050267146A1,OC1(c2nccs2)CCC2(CC1)OCCO2>>O=C1CCC(O)(c2nccs2)CC1,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US06002008,COc1ccc(OC)c2c(O)c(C#N)cnc12.O=P(Cl)(Cl)Cl>>COc1ccc(OC)c2c(Cl)c(C#N)cnc12,CN(C)C=O,,,,,val
US04760054,CC1(C)OCC(CO)O1.O=C(Cl)Cl>>CC1(C)OCC(COC(=O)Cl)O1,,ClCCl,c1ccccc1,,,val
US20080207654A1,CCCCc1nc(C)c(-c2ccc(OC(C)C)cc2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCCc1nc(C)c(-c2ccc(OC(C)C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US06380230B1,C=CC#N.O=C(OCc1ccccc1)c1cc2ccccc2[nH]1>>N#CCCn1c(C(=O)OCc2ccccc2)cc2ccccc21,,C1COCCO1,O,,,val
US20140155415A1,Br[Mg]c1ccccc1.Cc1c(C=NS(=O)(=O)c2ccc3c(c2)OCCCO3)oc2ccccc12>>Cc1c(C(NS(=O)(=O)c2ccc3c(c2)OCCCO3)c2ccccc2)oc2ccccc12,,CO,,C1CCOC1,,val
US20100168418A1,Cl.O=c1cnc2ccc(F)cc2n1CCN1CCC(NCc2ccc3ccccc3c2)CC1>>Cl.O=c1cnc2ccc(F)cc2n1CCN1CCC(NCc2ccc3ccccc3c2)CC1,,CCOC(C)=O,,ClC(Cl)Cl,,val
US20140336224A1,C=CC#N.O=C(Cc1ccc(Cl)cc1F)c1ccccc1F>>N#CCCC(C(=O)c1ccccc1F)c1ccc(Cl)cc1F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20080176829A1,CC1c2c(ccc3[nH]cc(Cl)c23)OCCN1C(=O)OC(C)(C)C.O=C(O)C(F)(F)F.O=S(=O)(Cl)c1ccccc1>>CC1NCCOc2ccc3c(c(Cl)cn3S(=O)(=O)c3ccccc3)c21.O=C(O)C(F)(F)F,,CN(C)C=O,,[H-].[Na+],,val
US20110218177A1,CC(C)(C)OC(=O)OC(=O)[O-].COc1cc(CN)ccc1O>>COc1cc(CNC(=O)OC(C)(C)C)ccc1O,,CC#N,,CCN(C(C)C)C(C)C,,val
US20030078426A1,Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccc(Oc3ccc4cccc(N)c4c3)cc21.O=C=NC12CC3CC(CC(C3)C1)C2>>Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccc(Oc3ccc4cccc(NC(=O)NC56CC7CC(CC(C7)C5)C6)c4c3)cc21,,CN(C)C=O,,,,val
US20160002228A1,C[Si](C)(C)CCOCCl.O=C1Cc2cc(Br)cnc2N1>>C[Si](C)(C)CCOCN1C(=O)Cc2cc(Br)cnc21,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US05719141,O=C(O)C1Cc2ccccc2N(C(=O)OCc2ccccc2)C1>>O=C(OCc1ccccc1)N1CC(CO)Cc2ccccc21,,C1CCOC1,CO,,,val
US20050026916A1,CSC1=N[C@@H](c2ccccc2)[C@@H](c2ccccc2)N1C(=O)OC(C)(C)C.NCC1CCCCC1>>CC(C)(C)OC(=O)N1C(NCC2CCCCC2)=N[C@@H](c2ccccc2)[C@H]1c1ccccc1,,CO,,,,val
US20150266881A1,Cc1cc(NC(=O)c2cccc([C@@H]3C[C@H]3N)c2)no1.Cl.O=C1CCC1>>Cc1cc(NC(=O)c2cccc([C@@H]3C[C@H]3NC3CCC3)c2)no1.Cl,,CC(=O)O,CO,Cl,O=C([O-])O.[Na+],val
US20050032786A1,COC(=O)c1ccccc1S.N#Cc1ccc(C(F)(F)F)cn1>>O=c1nc(-c2ccc(C(F)(F)F)cn2)sc2ccccc12,,Cc1ccccc1,,CCN(CC)CC,,val
US20050101647A1,Nc1nc(-c2ccccc2)ccc1[N+](=O)[O-]>>Nc1ccc(-c2ccccc2)nc1N,[Fe],CO,,Cl,[Na+].[OH-],val
US20120208815A1,CC(C)(C)OC(=O)NC1CCCN(c2ccncc2N)C1.Nc1ncc(Br)nc1C(=O)O>>CC(C)(C)OC(=O)NC1CCCN(c2ccncc2NC(=O)c2nc(Br)cnc2N)C1,,CCOC(C)=O,CN(C)C=O,ClCCCl,On1nnc2cccnc21,val
US20130079345A1,COc1ccccc1B(O)O.NS(=O)(=O)c1cccc(Nc2ncnc(Cl)n2)c1>>COc1ccccc1-c1ncnc(Nc2cccc(S(N)(=O)=O)c2)n1,,C1COCCO1,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20120214762A1,C#Cc1ccc2nc(OC3COC3)n(-c3ccnc(N)n3)c2c1.CC(=O)c1ncccn1>>CC(O)(C#Cc1ccc2nc(OC3COC3)n(-c3ccnc(N)n3)c2c1)c1ncccn1,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20080242677A1,CC(C)S(=O)(=O)Cl.COC(=O)C1CN1>>COC(=O)C1CN1S(=O)(=O)C(C)C,,ClCCl,,CCN(CC)CC,,val
US20140057900A1,N#Cc1ccc2[nH]c3ccccc3c2c1.O=C1CCC(=O)N1Br>>N#Cc1ccc2[nH]c3ccc(Br)cc3c2c1,,Cc1ccccc1,,CCOC(C)=O,,val
US20130137687A1,COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(F)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1.C[C@@H](O)C(F)(F)F>>COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(O[C@@H](C)C(F)(F)F)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040058903A1,C=Cc1ccccn1.Nc1ccc([N+](=O)[O-])cc1>>O=[N+]([O-])c1ccc(NCCc2ccccn2)cc1,,CC(C)O,,CCOC(C)=O,Cl,val
US20080004271A1,CC(C)N.CS(=O)c1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(C(N)=O)sc2n1>>CC(C)Nc1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(C(N)=O)sc2n1,,C1CCOC1,,,,val
US20090181956A1,CS(=O)(=O)c1ncccc1Cl.c1cc[nH]c1>>Clc1cccnc1-n1cccc1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20120245187A1,CC(C)(C)OC(=O)CN1CCc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cccc(C(F)(F)F)c3)c2)C1>>O=C(O)CN1CCc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cccc(C(F)(F)F)c3)c2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070032515A1,CCC(=O)C(C#N)c1ccc(OC)c(OC)c1.NN.O=C(O)C(F)(F)F.O=Cc1ccc(O)cc1>>CCc1n[nH]c2nc(-c3ccc(O)cc3)c3cc(OC)c(OC)cc3c12.O=C(O)C(F)(F)F,,CCO,,,,val
US20090291938A1,CN1CCC(N)CC1.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(C)(C)C(=O)N2C>>COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(C)(C)C(=O)N2C,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030176418A1,CCCOC1CCNCC1.Cc1ccc2c(c1)CCC(=O)N2CCCCl>>CCCOC1CCN(CCCN2C(=O)CCc3cc(C)ccc32)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05223498,CNCCCN.CSC(=N)Nc1ccccc1N1CCOCC1>>CN1CCCNC1=Nc1ccccc1N1CCOCC1,,CCO,,I,,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(C(=O)C2C(=O)OC(C)(C)OC2=O)CC1.Nc1n[nH]c2cccc(-c3ccccc3)c12>>CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4c(-c5ccccc5)cccc4nn23)CC1,,CC#N,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20130059834A1,CC(C)(C)NC(=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c2ncc(-c3nn(CCC4COC(C)(C)O4)c4cc(F)ccc34)nc12>>CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CCC(O)CO)c4cc(F)ccc34)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030040533A1,COC(=O)C(=Cc1ccc(OCCn2c(=O)sc3cc(C(=O)c4cccc(Cl)c4)ccc32)cc1)C(=O)OC.CON>>CON=C(c1cccc(Cl)c1)c1ccc2c(c1)sc(=O)n2CCOc1ccc(C=C(C(=O)OC)C(=O)OC)cc1,,CO,O,c1ccncc1,,val
US06169107A,CCOC(=O)c1cc2c(Cl)ccc(OCc3ccc(CNC(=O)OC(C)(C)C)cc3)c2n1C>>CCOC(=O)c1cc2c(Cl)ccc(OCc3ccc(CN)cc3)c2n1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120309738A1,CN(C)CC1CCCN1.Nc1cc(Cl)c(Cl)cc1[N+](=O)[O-]>>CN(C)CC1CCCN1c1cc(N)c([N+](=O)[O-])cc1Cl,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040176361A1,Cc1cccc(C(N)=O)c1N.O=C(Cl)C1CCN(C(=O)OCc2ccccc2)CC1>>Cc1cccc(C(N)=O)c1NC(=O)C1CCN(C(=O)OCc2ccccc2)CC1,,CN(C)C=O,ClC(Cl)Cl,CCN(CC)CC,O,val
US05236944,CC1(C)OC[C@H](CO)O1.O=S(=O)(Cl)c1ccc2ccccc2c1>>CC1(C)OC[C@H](COS(=O)(=O)c2ccc3ccccc3c2)O1,,O,,CCN(CC)CC,CCOC(C)=O,val
US20080306287A1,O=C(O)C1CCOCC1.O=S(Cl)Cl>>O=C(Cl)C1CCOCC1,,Cc1ccccc1,,,,val
US20110034468A1,Brc1nccs1.CC(C)(C)OC(=O)c1ccc(N)cc1>>O=C(O)c1ccc(Nc2nccs2)cc1,,CC(C)O,,C1COCCO1,Cl,val
US20050261268A1,CC(=O)N1C(C)CN(c2cc(-n3cnc(Nc4ccc(N)cc4)n3)ccn2)CC1C.ClCCOCCCl>>CC(=O)N1C(C)CN(c2cc(-n3cnc(Nc4ccc(N5CCOCC5)cc4)n3)ccn2)CC1C,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20040147543A1,CCCc1nc2c(N)nc3cc(Br)ccc3c2n1CCCCN.CS(=O)(=O)Cl>>CCCc1nc2c(N)nc3cc(Br)ccc3c2n1CCCCNS(C)(=O)=O,,ClC(Cl)Cl,,CCN(CC)CC,,val
US06518260B1,COC(=O)C(Cc1ccccc1)CP(=O)(O)C(Cc1ccccc1)NC(=O)OCc1ccccc1>>O=C(NC(Cc1ccccc1)P(=O)(O)CC(Cc1ccccc1)C(=O)O)OCc1ccccc1,,CO,,Cl,[Na+].[OH-],val
US20150232469A1,CC(C)Nc1nc(CO)c(CO)nc1N1CCC(Oc2ccc(F)cc2F)CC1>>CC(C)Nc1nc(C=O)c(C=O)nc1N1CCC(Oc2ccc(F)cc2F)CC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05268387,CCCCCCCCCC(O)C#CC(=O)OCC>>CCCCCCCCCC(O)C#CC(=O)O,,CCO,,[K+].[OH-],,val
US03947434,COc1ccc(OC(C)=O)cc1[N+](=O)[O-]>>COc1ccc(O)cc1[N+](=O)[O-],,O,,Cl,[Na+].[OH-],val
US20140274696A1,BrBr.COC(=O)c1nc(-c2ccc([Si](C)(C)C)cc2)c(C)c(N)c1Cl>>COC(=O)c1nc(-c2ccc(Br)cc2)c(C)c(N)c1Cl,,ClCCCl,,O=C([O-])[O-].[K+].[K+],,val
US20050153244A1,O=C1C2C3C=CC(C3)C2C(=O)N1O.O=S(=O)(Cl)CCCl>>O=C1C2C3C=CC(C3)C2C(=O)N1OS(=O)(=O)CCCl,,CCOC(C)=O,ClCCl,Cl,c1ccncc1,val
US05968985,COC(=O)c1cccc(C2=C(C=O)CCc3ccccc32)c1.NO>>COC(=O)c1cccc(C2=C(C=NO)CCc3ccccc32)c1,,CO,,Cl,C[O-].[Na+],val
US20090312309A1,Brc1ccc(N2CCNCC2)nc1.CCOC1(O[Si](C)(C)C)CC1>>Brc1ccc(N2CCN(C3CC3)CC2)nc1,,C1CCOC1,CC(=O)O,O,[BH3-]C#N.[Na+],val
US20160214934A1,CCOC(=O)C(C)Br.Cc1cc(OCCCc2c[nH]c3ccccc23)cc(C)c1Cl>>Cc1cc(OCCCc2cn(C(C)C(=O)O)c3ccccc23)cc(C)c1Cl,,CC#N,CN(C)C=O,O,[H-].[Na+],val
US20120245168A1,CCOC(OCC)C(=O)C#CC(C)(C)OC1CCCCO1.S=C1SCC(c2ccccc2)S1>>CCOC(OCC)C(=O)c1sc(=S)sc1C(C)(C)OC1CCCCO1,,ClCCl,,,,val
US20130345181A1,CN(C)C(=O)c1ccc(N)c(Cl)c1.O=C1CCC(=O)N1Cl>>CN(C)C(=O)c1cc(Cl)c(N)c(Cl)c1,,CC#N,,,,val
US05646165,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#CCSC[C@H](N)C(=O)O>>CC(C)(C)OC(=O)N[C@@H](CSCC#N)C(=O)O,,C1COCCO1,O,O=C([O-])O.[Na+],,val
US20070259886A1,C=C(C)c1cc(C(=O)N2Cc3cccc(OCCOCCOC)c3C2)c(OCc2ccccc2)cc1OCc1ccccc1>>COCCOCCOc1cccc2c1CN(C(=O)c1cc(C(C)C)c(O)cc1O)C2,[Pd],CO,,,,val
US20140288088A1,Cc1c([C@@H]2CO2)ccc2c1COC2=O.O=C1CNCCN1>>Cc1c([C@@H](O)CN2CCNC(=O)C2)ccc2c1COC2=O,,ClCCl,,,,val
US07452906B2,OCCN1CCC(c2cc(-c3ccncc3)c(-c3ccc4c(c3)CCC4=NO)o2)CC1>>O=C1CCc2cc(-c3oc(C4CCN(CCO)CC4)cc3-c3ccncc3)ccc21,,O,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20130165653A1,Cc1cc(C)cc(-c2ncc(Cl)nc2-c2cc(C)cc(C)c2)c1.Cc1cccc(C)c1B(O)O>>Cc1cc(C)cc(-c2ncc(-c3c(C)cccc3C)nc2-c2cc(C)cc(C)c2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,,O,O=C([O-])[O-].[Na+].[Na+],val
US20030225057A1,CC(C)Br.CC1CN(C(=O)C(F)(F)F)CCc2cc(O)c(Br)cc21>>CC(C)Oc1cc2c(cc1Br)C(C)CN(C(=O)C(F)(F)F)CC2,,CCOC(C)=O,ClCCl,C1CCC2=NCCCN2CC1,,val
US03975537,COC(=O)c1ccc(OC)c(Cl)c1.Cl>>COc1ccc(C(=O)Cl)cc1Cl,,O,,[Na+].[OH-],,val
US20160038486A1,COc1ccc(Cc2c(F)c(S(=O)(=O)Nc3ccncn3)cc(F)c2O[C@H]2CCC[C@@H]2c2ccnn2C)c(OC)c1>>Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(S(=O)(=O)Nc2ccncn2)cc1F,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20080207633A1,CN1CCC(CN2CCN(Cc3ccccc3)CC2)(c2ccccc2)CC1>>CN1CCC(CN2CCNCC2)(c2ccccc2)CC1,,CO,,,,val
US20150376208A1,CCOC(=O)CS.N#Cc1c(Br)ccc2ncccc12>>CCOC(=O)c1sc2ccc3ncccc3c2c1N,,CO,,C[O-].[Na+],,val
US05312904,COCC(O)(CBr)COC>>COCC1(COC)CO1,,O,,[Na+].[OH-],,val
US20070244095A1,Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]2CCCNc3cc4c(cc32)COC4)n1.O=Cc1ccc(C(=O)O)s1>>Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]2CCCN(Cc3ccc(C(=O)O)s3)c3cc4c(cc32)COC4)n1,,CC(Cl)Cl,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05945434,CCCCN1CCN(CCNC(=O)c2n[nH]c3ccccc23)CC1.OC1CCCC1>>CCCCN1CCN(CCNC(=O)c2nn(C3CCCC3)c3ccccc23)CC1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100279872A1,C#CC(C)(C)O.CCC(C)=O>>CCC(C)(O)C#CC(C)(C)O,,C1CCOC1,,[Li]CCCC,,val
US20090118467A1,NCCCC[C@H](NC(=O)CNOCc1ccccc1)C(=O)O>>NCCCC[C@H](NC(=O)CNO)C(=O)O,[Pd],OCC(F)(F)F,,,,val
US20030232808A1,C=O.Cl.O=C(c1nc2c(s1)CNCC2)N1CCN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CC1>>CC1Cc2nc(C(=O)N3CCN(S(=O)(=O)c4ccc5cc(Cl)ccc5c4)CC3)sc2CN1.Cl,,CC(=O)O,ClCCl,CCN(CC)CC,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05385919,Brc1ccccn1.COC(=O)c1cc2ccccc2[nH]1>>COC(=O)c1cc2ccccc2n1-c1ccccn1,O=[Cu],c1ccncc1,,O=C([O-])[O-].[K+].[K+],,val
US05952382,C=CCc1cc2ccc(-c3ccc(C(=O)OC)cc3)cc2cc1C12CC3CC(CC(C3)C1)C2.OO>>COC(=O)c1ccc(-c2ccc3cc(CCCO)c(C45CC6CC(CC(C6)C4)C5)cc3c2)cc1,,C1CCOC1,O,B1C2CCCC1CCC2,[Na+].[OH-],val
US20070027192A1,CC(C)(C)O.COC(=O)C1(C(=O)O)CC1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COC(=O)C1(NC(=O)OC(C)(C)C)CC1,,Cc1ccccc1,,CCN(CC)CC,,val
US20080293775A1,O=C(Cl)c1ccc(F)c(Cl)c1.c1ccccc1>>O=C(c1ccccc1)c1ccc(F)c(Cl)c1,,O,,,,val
US20080194629A1,COc1ccc(S(=O)(=O)N[C@@H]2C[C@H](C(=O)NCC3(CCCCO)c4ccccc4Oc4ccccc43)CN(C(=O)OCC3c4ccccc4-c4ccccc43)C2)cc1OC>>COc1ccc(S(=O)(=O)N[C@@H]2C[C@H](C(=O)NCC3(CCCC=O)c4ccccc4Oc4ccccc43)CN(C(=O)OCC3c4ccccc4-c4ccccc43)C2)cc1OC,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20110034454A1,Brc1ccc2[nH]ncc2c1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)n2ncc3cc(Br)ccc32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20080045521A1,c1cc(CCOC2CCCCO2)nc(NC2CCCC2)c1>>OCCc1cccc(NC2CCCC2)n1,,CO,,Cl,,val
US20150011720A1,C1=CC2C(C1)[C@@H]1C=C[C@H]2C1.OC[C@H]1O[C@@H](OC/C=C/c2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O>>C1=CC2C(C1)[C@@H]1C=C[C@H]2C1.OC[C@H]1O[C@@H](OC/C=C/c2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O,,Cc1ccccc1,,[K+].[OH-],,val
US20030166650A1,CC(N)c1cccc(N2CCO[C@H](CO)C2)c1.O=C(O)C=Cc1ccccc1>>C[C@H](NC(=O)C=Cc1ccccc1)c1cccc(N2CCOC(CO)C2)c1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,ClCCCl,val
US20060106048A1,CCSc1cc2c(c3c1OC(C)(C)C3)C(c1cccc(C(=O)NC(C)(C)C(N)=O)c1)=NC(C)(C)C2.CO>>CCS(=O)c1cc2c(c3c1OC(C)(C)C3)C(c1cccc(C(=O)NC(C)(C)C(N)=O)c1)=NC(C)(C)C2,,CO,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US05521179,CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)C(C(=O)OCc2ccccc2)c2ccccc2)c1=O)C(=O)C(F)(F)F>>CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)C(C(=O)O)c2ccccc2)c1=O)C(=O)C(F)(F)F,[Pd],CO,,,,val
US20090281092A1,C=CC1(F)CN(C2CCCC2)c2nc(Cl)ncc2N(C)C1=O.COc1cc(C(=O)O)ccc1N>>C=CC1(F)CN(C2CCCC2)c2nc(Nc3ccc(C(=O)O)cc3OC)ncc2N(C)C1=O,Cl,CC(C)O,,,,val
US07157487B2,CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1COCCC=O.COC(=O)CP(=O)(OC)OC>>COC(=O)/C=C/CCOC[C@@H]1C[C@H](F)CN1C(=O)OC(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20050234057A1,CC1(C)CN(c2cc(F)ccc2N2CCC(NC(=O)C3(NC(=O)c4ccco4)CCCCC3)C(O)C2)C1=O>>CC1(C)CN(c2cc(F)ccc2N2CCC(NC(=O)C3(NC(=O)c4ccco4)CCCCC3)C(=O)C2)C1=O,,CCOC(C)=O,CS(C)=O,CCN(CC)CC,,val
US20070043048A1,COC(=O)/C=C/c1ccc(-c2ccnc(SC)n2)s1.C[N+](=O)[O-]>>COC(=O)CC(C[N+](=O)[O-])c1ccc(-c2ccnc(SC)n2)s1,,CCOC(C)=O,,,,val
US05225402,CCOC(=O)CC(=O)OCC.O=Cc1ccccc1NC1CCN(Cc2ccccc2)CC1>>CCOC(=O)c1cc2ccccc2n(C2CCN(Cc3ccccc3)CC2)c1=O,,Cc1ccccc1,,C1CCNCC1,CC(=O)O,val
US05990133,Nc1cc(F)cc(-c2cccnc2)c1.O=C(Cl)Oc1ccccc1>>O=C(Nc1cc(F)cc(-c2cccnc2)c1)Oc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20150376160A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4sc(F)cc4NC(=O)OC(C)c4cc(F)ccc4C)cc3OC)cc2)CC1>>COc1cc(-c2sc(F)cc2NC(=O)OC(C)c2cc(F)ccc2C)ccc1-c1ccc(C2(C(=O)O)CC2)cc1,,CC(C)O,,Cl,[Na+].[OH-],val
US20070049633A1,O=[N+]([O-])c1ccc2c(-c3ccccc3Cl)n[nH]c2c1>>Nc1ccc2c(-c3ccccc3Cl)n[nH]c2c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20100029650A1,C1CCNC1.CC(C)OC(=O)N1CCC(COc2ccc(-c3ccc(C(=O)O)cc3)nc2)CC1>>CC(C)OC(=O)N1CCC(COc2ccc(-c3ccc(C(=O)N4CCCC4)cc3)nc2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040087577A1,CCOC(=O)c1c(O)c2sccc2n(N=Cc2ccccc2)c1=O.Nc1ccccc1S(N)(=O)=O>>Nn1c(=O)c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc21,,Cc1ccccc1,,Cl,[K+].[OH-],val
US04044049,CC(=O)OC(C)=O.O=C(O)c1cc(-c2ccc(F)cc2)ccc1O>>CC(=O)Oc1ccc(-c2ccc(F)cc2)cc1C(=O)O,,c1ccncc1,,,,val
US20060287362A1,CN1CCC(CO)CC1.COC(=O)C(O)(c1ccccc1)c1ccccc1>>CN1CCC(COC(=O)C(O)(c2ccccc2)c2ccccc2)CC1,,Cc1ccccc1,,[Na],,val
US20030125354A1,Cc1ccc(C(C)(C)C)cc1N.Nc1ccc(OCCN2CCOCC2)c2ccccc12.O=C(Cl)Cl>>Cc1ccc(C(C)(C)C)cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12,,ClCCl,,O=C([O-])O.[Na+],,val
US04900751,COc1cc2c(cc1OC)=NC(=S)N=2.COc1ccc([N+](=O)[O-])c(Cl)c1>>COc1ccc([N+](=O)[O-])c(Sc2nc3cc(OC)c(OC)cc3[nH]2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050261372A1,BrCCC=C(c1ccccc1)c1ccccc1>>BrCCCC(c1ccccc1)c1ccccc1,[Pd],CCO,,,,val
US20060111445A1,CCOC(=O)CCCBr.O=C1CCc2cc(I)c(O)cc21>>CCOC(=O)CCCOc1cc2c(cc1I)CCC2=O,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060229294A1,N[C@H](C(=O)NCCNc1nsc2ccccc12)c1ccccc1.O=S(=O)(Cl)c1ccccc1>>O=C(NCCNc1nsc2ccccc12)[C@@H](NS(=O)(=O)c1ccccc1)c1ccccc1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20130190289A1,COC(=O)c1sc(C#CC(C)(C)C)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)[C@@H](C)CC(=O)OC(C)(C)C>>COC(=O)c1sc(C#CC(C)(C)C)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)[C@@H](C)CC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04694080,COC(=O)c1ccccc1S(=O)(=O)NCC#N.COCCOCCl>>COCCOCN1C(C#N)=C(O)c2ccccc2S1(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20110039808A1,C1N2CN3CN1CN(C2)C3.CC1(C)OC(=O)c2ccc(CBr)cc2O1>>COC(=O)c1ccc(CN)cc1O,,ClC(Cl)Cl,,,,val
US06177440B1,COC(=O)COc1cccc2c1c1c(C(N)=O)cccc1n2Cc1ccccc1F>>NC(=O)c1cccc2c1c1c(OCC(=O)O)cccc1n2Cc1ccccc1F,,CCOC(C)=O,CO,Cl,[Na+].[OH-],val
US20060178418A1,O=C(Nc1ccncc1)c1ccc(OC(F)F)c2oc3ccccc3c12.O=C(OO)c1cccc(Cl)c1>>O=C(c1ccc(OC(F)F)c2oc3ccccc3c12)[NH+]([O-])c1ccncc1,,ClC(Cl)Cl,,,,val
US20130023541A1,CCN[C@@H]1CCN(c2ncccc2C(=O)OC(C)C)C1.O=Cc1ccc(CBr)cc1>>CCN(Cc1ccc(C=O)cc1)[C@@H]1CCN(c2ncccc2C(=O)OC(C)C)C1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160060233A1,CC(C)(C)OC(=O)NC1Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2C1.FC(F)(F)C(F)(F)Oc1ccc(-n2cnc(Br)n2)cc1>>CC(C)(C)OC(=O)NC1Cc2ccc(-c3ncn(-c4ccc(OC(F)(F)C(F)(F)F)cc4)n3)cc2C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,C1COCCO1,O=C([O-])O.[Na+],val
US20020042377A1,CC(C)(C)OC(=O)N1CCCC1C(=O)C(CCc1ccccc1)CCc1ccccc1.O=C([O-])C(=O)Cl>>O=C(O)C(=O)N1CCCC1C(=O)C(CCc1ccccc1)CCc1ccccc1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20050148627A1,CCOC(=O)C1=Cc2c(cc(C)c(Cl)c2C)OC1C(F)(F)F>>Cc1cc2c(c(C)c1Cl)C=C(C(=O)O)C(C(F)(F)F)O2,,CCO,O,Cl,[Na+].[OH-],val
US07994337B2,CCSc1nc(-c2cn(C)nc2-c2ccccc2F)ccc1[N+](=O)[O-]>>CCSc1nc(-c2cn(C)nc2-c2ccccc2F)ccc1N,,CCOC(C)=O,,Cl[Sn]Cl,,val
US20110144334A1,CC(=O)Cl.NC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1N>>CC(=O)Nc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(N)=O,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCCOC)cc1CC2CC>>CCC1Cc2cc(OCCCOC)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21,,CO,O,[Li]O,,val
US20100331326A1,Cc1cccc(NC(=O)NCCCl)c1>>Cc1cccc(N2CCNC2=O)c1,,C1CCOC1,CN(C)C=O,CCOC(C)=O,[H-].[Na+],val
US05021420,O=S1(=O)c2cccc3cccc(c23)N1CCCCl.c1ccc(N2CCNCC2)cc1>>O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccccc2)CC1,,Cc1ccccc1,,CCN(CC)CC,,val
US20090181950A1,COC(=O)Cc1ccc(O)cc1.OCCCN1CCCCCC1>>COC(=O)Cc1ccc(OCCCN2CCCCCC2)cc1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150218109A1,CN1C(=O)CC(=O)NC1=S.COc1cc(OC)c2ccccc2c1C=O>>COc1cc(OC)c2ccccc2c1C=C1C(=O)NC(=S)N(C)C1=O,,CCO,,,,val
US20080269210A1,CN(Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1)C(=O)CBr.OC1CCNCC1>>CN(Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1)C(=O)CN1CCC(O)CC1,,C1COCCO1,,CCN(CC)CC,,val
US05283252,CC(=O)CCl.NC(=S)C(c1ccc(OCc2ccc3ccccc3n2)cc1)C1CCCCCC1>>Cc1csc(C(c2ccc(OCc3ccc4ccccc4n3)cc2)C2CCCCCC2)n1,,O,,O=C([O-])O.[Na+],,val
US20100280030A1,CC(c1cccc([N+](=O)[O-])c1)n1c(=O)oc2cc(F)c(F)cc21>>CC(c1cccc(N)c1)n1c(=O)oc2cc(F)c(F)cc21,[Ni],C1CCOC1,,,,val
US20020198205A1,BrCc1ccccc1.Cc1ccncc1NC(=O)OC(C)(C)C>>Cc1cc[n+](Cc2ccccc2)cc1NC(=O)OC(C)(C)C.[Br-],,Cc1ccccc1,,,,val
US20150152063A1,COC[C@H](C)NC(=NC(=O)c1ccc(F)c(F)c1)Nc1n[nH]c2cc(C(F)(F)F)ccc12.O=S(=O)(O)O>>COC[C@H](C)NC(=NC(=O)c1ccc(F)c(F)c1)Nc1n[nH]c2cc(C(F)(F)F)ccc12.O=S(=O)(O)O,,CCOC(C)=O,,,,val
US20020119975A1,Cn1c(=O)[nH]c(=O)c2c(N)c([N+](=O)[O-])ccc21>>Cn1c(=O)[nH]c(=O)c2c(N)c(N)ccc21,[Pd],CO,,,,val
US20160031871A1,CC(=O)Nc1ncc(CCl)s1.Cc1ccc(CC2CCNCC2)cc1>>CC(=O)Nc1ncc(CN2CCC(Cc3ccc(C)cc3)CC2)s1,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20130210818A1,Brc1csc(Br)n1.OB(O)c1ccc(F)cc1>>Fc1ccc(-c2nc(Br)cs2)cc1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US05925638,CC(C)(C)OC(=O)N1CCN(C(COCc2ccccc2)c2ccc(F)cc2)CC1>>Fc1ccc(C(COCc2ccccc2)N2CCNCC2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US03998834,O=C(OCc1ccccc1)C1(Nc2ccccc2)CCN(CCc2ccccc2)CC1>>O=C(O)C1CCN(CCc2ccccc2)C(Nc2ccccc2)C1,[Pd],CO,,[NH4+].[OH-],,val
US20160176826A1,Clc1ncc(Cl)c(Cl)n1.NCC1CCCO1>>Clc1ncc(Cl)c(NCC2CCCO2)n1,,CO,,CCN(CC)CC,,val
US20060004017A1,COc1ccc2cc(F)c(Cl)nc2c1.C[Mg]Br>>COc1ccc2cc(F)c(C)nc2c1,[Cu]Br,C1CCOC1,,[Na+].[OH-],[Cl-].[NH4+],val
US20090198063A1,BrCC1OCCO1.COc1cnc2ccc(=O)[nH]c2n1>>COc1cnc2ccc(=O)n(CC3OCCO3)c2n1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US04851409,COC(=O)CCSC(SCCC(=O)OC)c1cccc(C=O)c1.Cc1ccc2ccc(Cl)cc2n1>>COC(=O)CCSC(SCCC(=O)OC)c1cccc(C=Cc2ccc3ccc(Cl)cc3n2)c1,,CC(=O)OC(C)=O,,,,val
US20040220191A1,Brc1ncccn1.CN[C@@H]1CCN(c2ccc(NC(=O)N3CCC(c4ccc(Cl)cc4)CC3)cc2)C1>>CN(c1ncccn1)[C@@H]1CCN(c2ccc(NC(=O)N3CCC(c4ccc(Cl)cc4)CC3)cc2)C1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20060247251A1,C#CCc1ccc(CO)cc1.N#Cc1ncc(Br)c(NCCC2CCCCC2)n1>>N#Cc1ncc2cc(Cc3ccc(CO)cc3)n(CCC3CCCCC3)c2n1,[Cu]I,CN(C)C=O,,CCN(CC)CC,[Cl-].[NH4+],val
US20120040957A1,COc1ccc2ncc(OCCCN3CCC(CN)CC3)nc2c1.O=Cc1ccc2c(n1)NC(=O)CO2>>COc1ccc2ncc(OCCCN3CCC(CNCc4ccc5c(n4)NC(=O)CO5)CC3)nc2c1,,CO,ClCCCl,CC(=O)O,[BH3-]C#N.[Na+],val
US20100112090A1,CCOC(=O)COc1cc(Cl)c(-n2c(=O)[nH]c3c(OC)nc(C(C)=O)nc32)cc1OCc1c(OC)ccc(F)c1F.CO.COC(OC)OC>>CCOC(=O)COc1cc(Cl)c(-n2c(=O)[nH]c3c(OC)nc(C(C)(OC)OC)nc32)cc1OCc1c(OC)ccc(F)c1F,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US05284837,CC(=O)Cl.CCOCC.OCCC(CO)COC(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(=O)OCCC(COC(C)=O)COC(c1ccccc1)(c1ccccc1)c1ccccc1,,CCOCC,CCOCC,CCN(CC)CC,O,val
US05144045,CCCCCCCCCCCCCCCCOCC(COC(c1ccccc1)(c1ccccc1)c1ccc(OC)cc1)OP(=O)(OC)OCCCCC>>CCCCCCCCCCCCCCCCOCC(CO)OP(=O)(OC)OCCCCC,,CO,ClC(Cl)Cl,,,val
US20130040975A1,C1COCCO1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=S(=O)(c1cc(Br)c(Cl)cc1O)N1CCCCc2ccccc21>>CC1(C)OC(c2cc(S(=O)(=O)N3CCCCc4ccccc43)c(O)cc2Cl)OC1(C)C,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20030125354A1,CC(C)(C)c1ccc(-c2cn[nH]c2)c([N+](=O)[O-])c1>>CC(C)(C)c1ccc(-c2cn[nH]c2)c(N)c1,[Pd],CCO,,,,val
US06881733B1,C1N2CN3CN1CN(C2)C3.O=C(O)C(F)(F)F.Oc1cc(Cl)c(F)cc1Br>>O=Cc1c(O)c(Br)cc(F)c1Cl,,O,,O=S(=O)(O)O,,val
US20100081641A1,CN(Cc1cnc(F)cc1-c1cccc2cc(-c3nc(Cl)ncc3F)sc12)C(=O)OC(C)(C)C.NCCn1cc[nH]c1=O>>CN(Cc1cnc(F)cc1-c1cccc2cc(-c3nc(NCCn4cc[nH]c4=O)ncc3F)sc12)C(=O)OC(C)(C)C,,CCCCO,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20150011527A1,CCCCCCCOc1ccc(C(=O)NN)cc1.COC(=O)[C@H](Cc1ccc(C(=O)O)cc1)NC(=O)c1ccc(C(C)(C)C)cc1>>CCCCCCCOc1ccc(C(=O)NNC(=O)c2ccc(C[C@H](NC(=O)c3ccc(C(C)(C)C)cc3)C(=O)OC)cc2)cc1,,C1CCOC1,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20130216498A1,CN(C)C(=O)Cl.N#Cc1ccc2ncc(-c3nccc(N[C@@H]4CCCNC4)n3)n2c1>>CN(C)C(=O)N1CCC[C@@H](Nc2ccnc(-c3cnc4ccc(C#N)cn34)n2)C1,,ClCCl,,CCN(CC)CC,,val
US05705522,CCOC(=O)[C@H](N)CC(=O)O.NO>>NC(CC(=O)NO)C(=O)O,,CO,,CCN(CC)CC,Cl,val
US20120184548A1,COC(=O)c1ccc(Cl)c(N)c1.COc1cc2c(cc1OC)NC(=O)C(C(=O)O)C2>>COC(=O)c1ccc(Cl)c(NC(=O)C2Cc3cc(OC)c(OC)cc3NC2=O)c1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05506267,CC(C)(C)OC(=O)CC[C@H](NC(=O)c1ccc(CNC(=O)CCSCC(COC(=O)CCCCCCCCCCCc2ccccc2)OC(=O)CCCCCCCCCCCc2ccccc2)cc1)C(=O)OC(C)(C)C>>O=C(O)CC[C@H](NC(=O)c1ccc(CNC(=O)CCSCC(COC(=O)CCCCCCCCCCCc2ccccc2)OC(=O)CCCCCCCCCCCc2ccccc2)cc1)C(=O)O,,O=C(O)C(F)(F)F,,,,val
US20090042931A1,CC(C)Cc1cc(-c2cccc(CBr)c2)c(S(=O)(=O)NC(C)(C)C)s1.c1c[nH]cn1>>CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(C)(C)C)s1,,C1COCCO1,,,,val
US20160159751A1,CS(=O)(=O)Nc1ccc(B(O)O)cc1.Clc1nc(NCC(c2ccccc2)c2ccccn2)c2ccccc2n1>>CS(=O)(=O)Nc1ccc(-c2nc(NCC(c3ccccc3)c3ccccn3)c3ccccc3n2)cc1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20020137672A1,COC(=O)CCCCCN.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COC(=O)CCCCCNC(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,Cl,val
US20080167287A1,COC(=O)c1ccc(-c2cnc(N)nc2)cc1Cl.O=CC(Cl)C1(c2ccc3ncccc3c2)CC1>>COC(=O)c1ccc(-c2cnc3ncc(C4(c5ccc6ncccc6c5)CC4)n3c2)cc1Cl,,CCO,,,,val
US20090214675A1,CC(=O)C(=Cc1cccc2c(=O)cc(C)oc12)C(=O)OCC1CCC1.CC(N)=CC#N>>CC1=C(C#N)C(c2cccc3c(=O)cc(C)oc23)C(C(=O)OCC2CCC2)=C(C)N1,,CCO,,,,val
US04383945,CC(C)(OC(=O)OCc1ccc([N+](=O)[O-])cc1)[C@H]1C(=O)N[C@@H]1CC(=O)CC(=O)OCc1ccc([N+](=O)[O-])cc1.Cc1ccc(S(=O)(=O)N=[N+]=[N-])cc1>>CC(C)(OC(=O)OCc1ccc([N+](=O)[O-])cc1)[C@H]1C(=O)N[C@@H]1CC(=O)C(=[N+]=[N-])C(=O)OCc1ccc([N+](=O)[O-])cc1,,CC#N,,CCN(CC)CC,,val
US20140329822A1,CC(C)(C)OC(=O)NCC1CCNCC1.Clc1ncnc(Cl)n1>>CC(C)(C)OC(=O)NCC1CCN(c2ncnc(Cl)n2)CC1,,CC#N,,CCN(C(C)C)C(C)C,O,val
US20150361059A1,C[C@@H](C(=O)NC1CS(=O)(=O)c2ccccc2N(Cc2ccccc2)C1=O)N(C)C(=O)OC(C)(C)C.Cl>>CN[C@@H](C)C(=O)NC1CS(=O)(=O)c2ccccc2N(Cc2ccccc2)C1=O.Cl,,CO,,CCOCC,,val
US05763474,CCCCOc1c(NC(C)C(C)(C)C)c(=O)c1=O.NCc1ccc(Cl)cc1Cl>>CC(Nc1c(NCc2ccc(Cl)cc2Cl)c(=O)c1=O)C(C)(C)C,,C1CCOC1,,,,val
US20060069140A1,CC(=O)c1c(C)nn(-c2ccc(Cl)nn2)c1O.COC(=O)c1ccc(C(=O)NN)cc1>>COC(=O)c1ccc(C(=O)NNC(C)=C2C(=O)N(c3ccc(Cl)nn3)N=C2C)cc1,,CS(C)=O,,,,val
US20060194782A1,CCc1cccc(C)c1CN.Nc1cc(Br)nc(Br)c1[N+](=O)[O-]>>CCc1cccc(C)c1CNc1nc(Br)cc(N)c1[N+](=O)[O-],,CC#N,,CCN(CC)CC,,val
US20050187228A1,Clc1nc(Cl)c2ncn(C3CCOC3)c2n1.NCc1cccc(I)c1>>Clc1nc(NCc2cccc(I)c2)c2ncn(C3CCOC3)c2n1,,CCCCO,,,,val
US20090227588A1,O=C(Nc1ccc([N+](=O)[O-])cn1)C1CCCCC1>>Nc1ccc(NC(=O)C2CCCCC2)nc1,[Pd],CO,,,,val
US20160222014A1,CN(c1ncccc1CO)S(C)(=O)=O.O=S(Cl)Cl>>CN(c1ncccc1CCl)S(C)(=O)=O,,ClCCl,,,,val
US20100168167A1,BrP(Br)Br.OCc1csc2ccccc12>>BrCc1csc2ccccc12,,CCOCC,,,,val
US20140256705A1,CCOC(=O)CC(C)=O.N#CC(N)c1ccccc1Oc1ccccc1>>CCOC(=O)/C=C(\C)NC(C#N)c1ccccc1Oc1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20100273764A1,CC(=O)Nc1ccc(Nc2ncccc2-c2ncnc3c2ncn3C2CCCCO2)cn1>>Nc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cn1,,Cl,,,,val
US20090054435A1,COCOc1ccccc1C(=O)c1ccc(O)cc1.Cc1oc(-c2ccccc2)nc1CCl>>COCOc1ccccc1C(=O)c1ccc(OCc2nc(-c3ccccc3)oc2C)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150353553A1,COc1ccc(Cn2cnc3nc(Cl)nc(Cl)c32)cc1.C[C@@H](N)C1CCC1>>COc1ccc(Cn2cnc3nc(Cl)nc(N[C@H](C)C4CCC4)c32)cc1,,CCO,,,,val
US20060074086A1,CCNC(=O)NCc1cccc(-c2ccc(C(C)(C)CCCNC(=O)C(C)(C)C)cc2O)c1>>CCNC(=O)NCc1cccc(-c2ccc(C(C)(C)CCCNCC(C)(C)C)cc2O)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140066426A1,Cc1ccc(S(=O)(=O)CC(I)c2ccc(Cl)cc2)cc1>>Cc1ccc(S(=O)(=O)/C=C/c2ccc(Cl)cc2)cc1,,CC#N,,CCN(CC)CC,,val
US20110130398A1,CCOC(=O)CNc1ccc(NC(=O)OC(C)(C)C)cc1>>CCOC(=O)CNc1ccc(N)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150210688A1,FC(F)(F)c1c[nH]c(COCc2ccccc2)n1.O=C1CCC(=O)N1I>>FC(F)(F)c1nc(COCc2ccccc2)[nH]c1I,,CC#N,O,,,val
US04737444,CCO.CCO[Si]([O-])([O-])[O-]>>CCO.CCO[Si](O)(O)O,,CCO,,Cl,,val
US20080300266A1,Clc1ccc(CN[C@H]2CCNC2)c(Cl)c1.N#Cc1ccc(Cl)nc1>>N#Cc1ccc(N2CC[C@H](NCc3ccc(Cl)cc3Cl)C2)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20080262042A1,CN(Cc1cn(S(=O)(=O)c2ccccc2)c(-c2cccnc2C(F)(F)F)c1F)C(=O)OC(C)(C)C.Cl>>CNCc1cn(S(=O)(=O)c2ccccc2)c(-c2cccnc2C(F)(F)F)c1F.Cl,,CCO,,CCOC(C)=O,,val
US20070287724A1,C=CS(C)(=O)=O.CCOCc1nc2cnc3ccccc3c2n1CC1(O)CCN(C(=O)OC(C)(C)C)CC1>>CCOCc1nc2cnc3ccccc3c2n1CC1(OCCS(C)(=O)=O)CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,[H-].[Na+],,val
US20060135597A1,CC(C)OB(OC(C)C)OC(C)C.CN(C)c1ncc(Br)cn1.Cl>>CN(C)c1ncc(OB(O)O)cn1.Cl,,C1CCOC1,,[Li]CCCC,,val
US20150329523A1,COc1cc(NC(=O)OC(C)(C)C)cc(OCCN2CCOCC2)c1.Cl>>COc1cc(N)cc(OCCN2CCOCC2)c1.Cl,,CC(C)O,,,,val
US20150266895A1,CCN1CCc2nc(NC(=O)N[C@H](C)c3ccccc3)cc3c2c1nn3C(c1ccccc1)(c1ccccc1)c1ccccc1>>CCN1CCc2nc(NC(=O)N[C@H](C)c3ccccc3)cc3[nH]nc1c23,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20150037280A1,Cc1c(C(=O)Nc2cc(F)c(O)cc2F)c(=O)n(-c2ccccc2)n1C.NC(=O)c1nccc(Cl)c1Cl>>Cc1c(C(=O)Nc2cc(F)c(Oc3ccnc(C(N)=O)c3Cl)cc2F)c(=O)n(-c2ccccc2)n1C,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20020107392A1,N#Cc1c(N)cccc1F.OCCN1CCOCC1>>N#Cc1c(N)cccc1OCCN1CCOCC1,,CN1CCCC1=O,,O,[H-].[Na+],val
US20130123277A1,CCC1c2[nH]c3ccc(C)cc3c2CCN1C.c1cc(C2CO2)ccn1>>CCC1c2c(c3cc(C)ccc3n2CC(O)c2ccncc2)CCN1C,,CN(C)C=O,,O,[H-].[Na+],val
US06492403B1,COC(=O)COc1cccc(-c2csc(-c3cc(C=NNC(=O)OC(C)(C)C)sc3C)n2)c1>>Cc1sc(C=NNC(=O)OC(C)(C)C)cc1-c1nc(-c2cccc(OCC(=O)O)c2)cs1,,C1CCOC1,,[Na+].[OH-],,val
US20080085886A1,ON=Cc1cncc(Cl)c1Cl>>N#Cc1cncc(Cl)c1Cl,,ClCCl,,O=C(c1ncc[nH]1)c1ncc[nH]1,,val
US20050096380A1,CCOc1cc2c(cc1C(C)=C(F)C=CC(C)=CC(=O)[O-])C(C(C)C)=CC(C)(C)O2>>CCOc1cc2c(cc1C(C)=C(F)C=CC(C)=CC(=O)O)C(C(C)C)=CC(C)(C)O2,,CCO,,C1CCOC1,[Na+].[OH-],val
US20150028265A1,CCCCC(CC)C[Mg]Br.CCCCC(CC)C[Si](Cl)(Cl)Cl>>CCCCC(CC)C[Si](Cl)(Cl)CC(CC)CCCC,,C1CCOC1,,,,val
US20130317066A1,O=[N+]([O-])c1cc(Cl)c(O)cc1F>>Nc1cc(Cl)c(O)cc1F,[Zn],C1CCOC1,CO,[Cl-].[NH4+],,val
US20090270402A1,CC1(C(=O)NNc2ccc(-c3c(-c4ccc(F)cc4F)nc4n3CCC4)nn2)CC1>>CC1(c2nnc3ccc(-c4c(-c5ccc(F)cc5F)nc5n4CCC5)nn23)CC1,,C1COCCO1,,O=S(Cl)Cl,,val
US20130150325A1,CC(C)(O)Cc1cccc(COS(C)(=O)=O)c1.Cc1cc(/C(F)=C/c2ccc(C(C)(C)C(F)(F)F)cc2)n[nH]1>>Cc1cc(/C(F)=C/c2ccc(C(C)(C)C(F)(F)F)cc2)nn1Cc1cccc(CC(C)(C)O)c1,,C1COCCO1,,CC(C)(C)[O-].[K+],,val
US06048868,CCOC(=O)C(CCC#N)C(=O)OCC.COc1ccc2[nH]cc(CCN)c2c1>>CCOC(=O)C1CCC2c3[nH]c4ccc(OC)cc4c3CCN2C1=O,[Pd],CC(=O)O,,,,val
US20130059834A1,CC(C)(CO)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-n3ncc4cc(F)ccc43)nc12>>CC(C)(CO)NC(=O)c1c[nH]c2ncc(-n3ncc4cc(F)ccc43)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090076046A1,O=S(=O)(c1ccccc1)n1cc(Cc2ccc(NCc3cncc(F)c3)nc2)c2cc(Cl)cnc21>>Fc1cncc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)c1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US05604237,O=[N+]([O-])c1ccc(OCCCBr)cc1.c1ccc2c(c1)CCNC2>>O=[N+]([O-])c1ccc(OCCCN2CCc3ccccc3C2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150299188A1,CC(=O)O.COc1cc(N)c(C=O)c(C2CC2)n1.Nc1cc2c(cc1Cl)CCC(c1ncccc1F)O2>>COc1cc2c(c(C3CC3)n1)CN(c1cc3c(cc1Cl)CCC(c1ncccc1F)O3)C(=O)N2,,CC(=O)O,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130274253A1,C[C@H]1Cc2ccccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1.O=C1CCC(=O)N1Cl>>C[C@H]1Cc2ccccc2N1C(=O)Cc1nc(N2CCOCC2)c(Cl)c(=O)[nH]1,,ClC(Cl)Cl,,ClCCl,O,val
US20070259881A1,CC(C)CNc1c(N)cnc2ccccc12.O=C(Cl)CCl>>CC(C)Cn1c(CCl)nc2cnc3ccccc3c21,,ClCCCl,,CCN(CC)CC,ClCCl,val
US05593989,NO.O=C1C2=C(C=C3OCCC13)CCCO2>>ON=C1C2=CCOC2=CC2=C1OCCC2,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20110275695A1,CN(C)CCOC1=Cc2ccccc2Sc2ccc(Cl)cc21.Cl>>CN(C)CCOC1=Cc2ccccc2Sc2ccc(Cl)cc21.Cl,,CCOCC,,,,val
US04477445,BrCCBr.CC(C)[Mg]Cl.C[Si](C)(C)Cl.Oc1ccc(Br)cc1>>C[Si](C)(C)Oc1ccc([Mg]Br)cc1,,C1CCOC1,,[Mg],,val
US20020082426A1,CC(C)C[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)N1CC(=O)C(OCC(=O)OC(C)(C)C)C1>>CC(C)C[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)N1CC(=O)C(OCC(=O)O)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04103086,CC(=O)O.CC(C)(C)OC(=O)N[C@H]1C(=O)N2C(C(=O)OCC(Cl)(Cl)Cl)=CSC[C@H]12>>CCCCOC(=O)N[C@H]1C(=O)N2C(C(=O)O)=CSC[C@H]12,[Zn],CN(C)C=O,O,Cl,,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(OC3CCCCO3)cc(OC)c21>>CCOC(=O)CC1OB(O)c2cc(O)cc(OC)c21,,C1CCOC1,,Cl,,val
US04022900,CN1CCc2c(N)cccc2C1.COc1cc(C(=O)Cl)cc(OC)c1OC>>COc1cc(C(=O)Nc2cccc3c2CCN(C)C3)cc(OC)c1OC,,c1ccccc1,,O=C([O-])O.[K+],,val
US20060223849A1,BrCc1ccccc1.COC(=O)c1cccc2[nH]c(N)nc12>>COC(=O)c1cccc2c1nc(N)n2Cc1ccccc1,,CS(C)=O,,,,val
US04882432,NC12CC3CC(CC(C3)C1)C2.NCCCN1CCN(c2cccc(Cl)c2)CC1.O=C(Cl)OC(Cl)(Cl)Cl>>O=C(NCCCN1CCN(c2cccc(Cl)c2)CC1)NC12CC3CC(CC(C3)C1)C2,,ClCCl,,CCN(CC)CC,Cl,val
US06037367,CCO.COc1ccc(C(C#Cc2ccccc2)CC(=O)O)cc1OC1CCCC1>>CCOC(=O)CC(C#Cc1ccccc1)c1ccc(OC)c(OC2CCCC2)c1,O=S(=O)(O)O,,,,,val
US04994452,BrCc1ccccc1.C1CCOC1.CCC1CNc2c3c(nc4cccc(c24)O1)CCCC3>>CCC1Oc2cccc3nc4c(c(c23)N(Cc2ccccc2)C1=O)CCCC4,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20130281490A1,CCOC(=O)CCl.c1ccc(CNCc2ccccc2)cc1>>CCOC(=O)CN(Cc1ccccc1)Cc1ccccc1,,CCO,,,,val
US20020006937A1,Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(C#CCO)sc21>>Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCCO)sc21,[Pd],CCO,,ClCCl,,val
US20080108648A1,CCCS(=O)(=O)Cl.COC(=O)c1cccc(-c2nc(C(=O)c3ccc(N)c(OC)c3)n3ccccc23)c1>>CCCS(=O)(=O)Nc1ccc(C(=O)c2nc(-c3cccc(C(=O)OC)c3)c3ccccn23)cc1OC,,ClCCl,c1ccncc1,,,val
US20090124666A1,O=Cc1ccc(Br)cn1.[C-]#[N+]C(C)S(=O)(=O)c1ccc(C)cc1>>Cc1ncoc1-c1ccc(Br)cn1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20050197350A1,COc1nc(N[C@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)ncc1C>>COc1nc(N[C@@H]2CC[C@H](N)CC2)ncc1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US05393814,CCCCCCCC/C=C\CCCCCCCCCCCCN.O=C1C=CC(=O)O1>>CCCCCCCC/C=C\CCCCCCCCCCCCNC(=O)/C=C\C(=O)O,,ClC(Cl)(Cl)Cl,,,,val
US04599357,CC(O)=S.CCOC(=O)C1Cc2ccccc2N1C(=O)C(C)Br>>CCOC(=O)C1Cc2ccccc2N1C(=O)C(C)SC(C)=O,,CCO,,[Na],,val
US05455238,O=CC(=O)O.Oc1cccc(F)c1O>>O=C(O)C(O)c1ccc(F)c(O)c1O,,O,,Cl,[Na+].[OH-],val
US20150087663A1,CCC(N)c1nc2cccc(C)c2c(=O)n1-c1ccccc1C.Cc1noc(-c2c(N)ncnc2Cl)n1>>CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(C)c2c(=O)n1-c1ccccc1C,,CCCCO,,CCN(C(C)C)C(C)C,,val
US05763489,CC(C)(C)[Si](Oc1cccc2c1CCCC2=O)(c1ccccc1)c1ccccc1.CCOC(=O)OCC>>CCOC(=O)C1CCc2c(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cccc2C1=O,,Cc1ccccc1,,[H-].[Na+],,val
US20160207928A1,COc1cc2c(cc1Br)CCS2.O=C(OO)c1cccc(Cl)c1>>COc1cc2c(cc1Br)CCS2(=O)=O,,ClC(Cl)Cl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US05380721,COc1cc2c(cc1OC)C(=O)OC2=O.Cl[Mg]c1ccccc1>>COc1cc(C(=O)O)c(C(=O)c2ccccc2)cc1OC,,C1CCOC1,,Cl,[Cl-].[NH4+],val
US05166170,CCCCCCCCOC(=O)Cl.Nc1ccccc1C1Cc2ccccc2N1>>CCCCCCCCOC(=O)Nc1ccccc1C1Cc2ccccc2N1,,ClCCl,,c1ccncc1,,val
US20150038528A1,COC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O.N[C@H](CC(=O)O)c1ccccc1>>N#Cc1nc(C(=O)N[C@H](CC(=O)O)c2ccccc2)c(O)c2ccc(Oc3ccccc3)cc12,,COCCO,,C[O-].[Na+],,val
US06184394B2,CCOC(=O)C1(Br)CCOC1OCC>>CCOC(=O)c1ccoc1,,Cc1ccccc1,,C,C[O-].[Na+],val
US20110311474A1,CCC1CC(=O)CC1c1nnc2cnc3c(ccn3COCC[Si](C)(C)C)n12.CS(=O)(=O)Cl>>CCC1CC(OS(C)(=O)=O)CC1c1nnc2cnc3c(ccn3COCC[Si](C)(C)C)n12,,ClCCl,,,,val
US20030236252A1,CC=O.CCC[C@@H](CSc1ccc(F)cc1)N[C@@H]1CC[C@@H](c2ccc3[nH]c(=O)oc3c2)CC1>>CCC[C@@H](CSc1ccc(F)cc1)N(CC)[C@@H]1CC[C@@H](c2ccc3[nH]c(=O)oc3c2)CC1,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20130165412A1,Brc1cnc(Br)cn1.NN>>NNc1cnc(Br)cn1,,CC(C)O,,O,,val
US05891871,COC(=O)C(C)c1ccc2c(c1)OCO2.O=C(O)c1ccc2c(c1)OCO2>>COC(=O)C(C)c1cc2c(cc1C(=O)c1ccc3c(c1)OCO3)OCO2,,ClCCCl,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20150018422A1,CCOC(=O)CCc1ccnc(COc2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)c2)c1>>COc1ccc(F)c(-c2ccc(OCc3cc(CCC(=O)O)ccn3)cc2CC(C)(C)C)c1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20090247577A1,OC/C=C/c1cc(F)cc(F)c1>>O=C/C=C/c1cc(F)cc(F)c1,O=[Mn]=O,ClCCl,,,,val
US20100048556A1,CC(C)c1ncc[nH]1.CCOC(=O)c1ccc(F)c([N+](=O)[O-])c1>>CCOC(=O)c1ccc(-n2ccnc2C(C)C)c([N+](=O)[O-])c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US05391571,CC1CCN(C(=O)Cl)CC1.COC(=O)c1cc(Oc2ccccc2)ccc1O>>COC(=O)c1cc(Oc2ccccc2)ccc1OC(=O)N1CCC(C)CC1,,c1ccccc1,,[H-].[Na+],,val
US20070232627A1,CC(C)c1ccc2c(Nc3cc(C(=O)Nc4ccc(C(F)(F)F)cn4)ccc3Oc3ccc(NC(=O)OC(C)(C)C)cc3)ncnc2n1>>CC(C)c1ccc2c(Nc3cc(C(=O)Nc4ccc(C(F)(F)F)cn4)ccc3Oc3ccc(N)cc3)ncnc2n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20090324581A1,COC(=O)c1ccc(C(F)(F)F)c(CC(C)C)c1>>CC(C)Cc1cc(CO)ccc1C(F)(F)F,,C1CCOC1,,Cl,[BH4-].[Li+],val
US20160272621A1,CB(O)O.O=[N+]([O-])c1cnc(Cl)cc1N1CCC(F)(F)CC1>>Cc1cc(N2CCC(F)(F)CC2)c([N+](=O)[O-])cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20140051692A1,C=CCN1CCOc2cc(C)c(B3OC(C)(C)C(C)(C)O3)cc21.COC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc(-c3cccc(Br)c3)nn2c1I>>C=CCN1CCOc2cc(C)c(-c3c([C@H](OC(C)(C)C)C(=O)OC)c(C)nc4cc(-c5cccc(Br)c5)nn34)cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,N#N,O=C([O-])[O-].[Na+].[Na+],val
US20160052912A1,CCOc1cc(F)c(Cn2nc(-c3nc(N)c(/N=N/c4ccccc4)c(N)n3)c3ccccc32)c(F)c1>>CCOc1cc(F)c(Cn2nc(-c3nc(N)c(N)c(N)n3)c3ccccc32)c(F)c1,[Pd],CN(C)C=O,,,,val
US20060052408A1,ClC(Cl)(Cl)Cl.OC[C@]1(c2ccccc2)C[C@H]1COCc1ccccc1>>ClC[C@]1(c2ccccc2)C[C@H]1COCc1ccccc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060148862A1,CC(C)(C)OC(=O)Nc1cccc(Br)n1.CI>>CN(C(=O)OC(C)(C)C)c1cccc(Br)n1,,CN(C)C=O,O,[H-].[Na+],,val
US20130019348A1,CC(C)C(=O)OCBr.COc1ccc(NC(N)=S)c(C)c1>>Br.COc1ccc(/N=C(\N)SCOC(=O)C(C)C)c(C)c1,,CC(C)=O,,,,val
US06323235B1,COC(=O)COc1cccc2c(CCSCCc3ccccc3)c(C)oc12.O=C1CCC(=O)N1Br>>COC(=O)COc1cccc2c(CCS(=O)CCc3ccccc3)c(C)oc12,,CO,,O,,val
US20110144105A1,CC(=O)c1ccc(C(=CC2CCCC2)c2cc3cccnc3[nH]2)cc1>>CC(O)c1ccc(C(CC2CCCC2)c2cc3cccnc3[nH]2)cc1,[Pd],CO,,,,val
US20120077799A1,Nc1nccnc1Cl.OB(O)c1ccc(Oc2ccccc2)cc1>>Nc1nccnc1-c1ccc(Oc2ccccc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20080176883A1,CC1CN(Cc2ccccc2)CCC1(O)c1ccc(F)cc1>>CC1CNCCC1c1ccc(F)cc1,,CCO,,Cl,,val
US20110201604A1,CNc1cc(C#N)ccc1N.Nc1nc2ccc(OC(F)(F)F)cc2s1.S=C(n1ccnc1)n1ccnc1>>Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2ccc(C#N)cc21,,ClCCCl,,,,val
US20090312338A1,NNC1CCCCC1.O=Cc1cnc2[nH]ccc2c1Cl>>c1cc2c(ncc3cnn(C4CCCCC4)c32)[nH]1,,CC(C)(C)O,,CCN(C(C)C)C(C)C,Cl,val
US20120122842A1,NOCc1ccccc1.O=Cc1ccc(NC(=O)N2Cc3ccccc3C2)cc1>>O=C(Nc1ccc(/C=N/OCc2ccccc2)cc1)N1Cc2ccccc2C1,,CO,O,Cl,CC(=O)[O-].[Na+],val
US20090163524A1,CC(C)(C)OC(=O)NC1(C(=O)O)CCN(c2ncnc3[nH]ccc23)CC1.C[C@H](N)c1ccc(Cl)cc1>>C[C@H](NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110076276A1,CC(C)I.Cc1cc(C#N)cc(C(=O)c2[nH]c(=O)[nH]c(=O)c2C(C)C)c1>>Cc1cc(C#N)cc(C(=O)c2c(C(C)C)c(=O)[nH]c(=O)n2C(C)C)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080312226A1,O=C(Nc1cccnc1)OCC(Cl)(Cl)Cl.c1ccc(-c2nsc(N3CCNCC3)n2)nc1>>O=C(Nc1cccnc1)N1CCN(c2nc(-c3ccccn3)ns2)CC1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US20080200448A1,CCOC(=O)CCCC(=O)CC(=O)OCC.COC(OC)N(C)C>>CCOC(=O)CCCC(=O)C(=CN(C)C)C(=O)OCC,,Cc1ccccc1,,,,val
US20110212918A1,CC(=O)O.N=C(NO)c1cc(NC(=O)C(F)(F)F)cnc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2>>Cc1nc(-c2cc(NC(=O)C(F)(F)F)cnc2S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)no1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20070244095A1,O=C1Nc2c(ccc3c2CCC3)C1=O.OO>>Nc1c(C(=O)O)ccc2c1CCC2,,O,,Cl,[Na+].[OH-],val
US20110039693A1,CNc1ccnc(OC)n1.Cc1cc(S(=O)(=O)Cl)ccc1Oc1ncc(C(F)(F)F)cc1Cl>>COc1nccc(CNS(=O)(=O)c2ccc(Oc3ncc(C(F)(F)F)cc3Cl)c(C)c2)n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100105700A1,CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C.C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O>>CC(C)[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]32)C1.CC(C)[Si](=O)C(C)C,,ClCCl,,Cc1cccc(C)n1,,val
US20070276000A1,COc1ccc(-c2c(C)cc3ccc(OC)cc3c2Oc2ccc(/C=C/C(=O)O)cc2)cc1>>Cc1cc2ccc(O)cc2c(Oc2ccc(/C=C/C(=O)O)cc2)c1-c1ccc(O)cc1,,CO,ClC(Cl)Cl,,,val
US20080214615A1,CNCc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O.Cc1ccc(N=C=O)cc1C>>Cc1ccc(NC(=O)N(C)Cc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)cc1C,,C1CCOC1,,CCN(CC)CC,Cl,val
US04053509,NCCc1ccc(O)c(O)c1.O=C(Cl)C1CC1>>O=C(NCCc1ccc(O)c(O)c1)C1CC1,,c1ccncc1,,Cl,,val
US04252802,CONC(=O)CON1C(=O)c2ccccc2C1=O.Cl>>CONC(=O)CON.Cl,,CO,,NN,,val
US20160264578A1,COc1ccc(-n2c(=O)c3c(CN(C)C)n(-c4ccc([N+](=O)[O-])cc4)nc3n(Cc3c(F)cccc3F)c2=O)nn1>>COc1ccc(-n2c(=O)c3c(CN(C)C)n(-c4ccc(N)cc4)nc3n(Cc3c(F)cccc3F)c2=O)nn1,[Pd],CO,,,,val
US06174884B1,CC(C)(C)OC(=O)NN.CCCCCCC(C)=O>>CCCCCCC(C)=NNC(=O)OC(C)(C)C,,C1CCCCC1,,,,val
US20050171180A1,CCC(CC)C(O)c1ccnn1S(=O)(=O)c1ccc(C)cc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCC(CC)C(N=[N+]=[N-])c1ccnn1S(=O)(=O)c1ccc(C)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130005574A1,C=C[Sn](CCCC)(CCCC)CCCC.COC(=O)c1nc(Br)cc(N)c1OC>>C=Cc1cc(N)c(OC)c(C(=O)OC)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,ClCCCl,,,,val
US20100267666A1,CN(C)CCO.COCOc1cc(-c2cnc3c(n2)c(C(=O)C(C)(C)C)cn3COCC[Si](C)(C)C)cc(N2CCC(C)(C)C2)c1>>CN(C)CCOc1cc(-c2cnc3c(n2)c(C(=O)C(C)(C)C)cn3COCC[Si](C)(C)C)cc(N2CCC(C)(C)C2)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070117854A1,N#CC(C#N)CCC(F)(F)F.O=[N+]([O-])c1ccn(CCl)c1>>N#CC(C#N)(CCC(F)(F)F)Cn1ccc([N+](=O)[O-])c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US07253161B2,CCOP(=O)(OCC)c1cccc(Oc2ccc3c(c2)S(=O)(=O)NC2CCCN32)c1>>O=P(O)(O)c1cccc(Oc2ccc3c(c2)S(=O)(=O)NC2CCCN32)c1,,CC#N,,C[Si](C)(C)Br,,val
US20090143372A1,CC(C)S(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(Br)cc23)CC1.CC1(C)OB(c2csc(C=O)c2)OC1(C)C>>CC(C)S(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4csc(C=O)c4)cc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06177419B1,CC(C)OB(OC(C)C)OC(C)C.COc1ccc(OC2CCCCO2)c(Br)c1>>COc1ccc(O)c(B(O)O)c1,,C1CCOC1,,[Li]CCCC,,val
US20100305122A1,CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(Cl)c([N+](=O)[O-])c4)c(Oc4cnc5[nH]ccc5c4)c3)CC2)=C(c2ccc(Cl)cc2)C1.COc1ccc(CN)cc1>>COc1ccc(CNc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CC(C)(C)CC5)CC4)cc3Oc3cnc4[nH]ccc4c3)cc2[N+](=O)[O-])cc1,,CO,CS(C)=O,CCN(C(C)C)C(C)C,,val
US20020156296A1,C=CCBr.CC(C)(C)C(=O)Oc1ccc(O)cc1C(C)(C)C>>C=CCOc1ccc(OC(=O)C(C)(C)C)c(C(C)(C)C)c1,,CN(C)C=O,,[H-].[Na+],,val
US20110044938A1,CCNC(=O)OC[C@H]1CCc2c(sc(NC(=O)/C=C/c3cccnc3)c2C#N)C1>>CCNC(=O)OC[C@H]1CCc2c(sc(NC(=O)CCc3cccnc3)c2C#N)C1,[Pd],CO,,,,val
US20110152248A1,NNc1ccc(F)cc1Br.O=C1CCN2CCC1CC2>>Fc1cc(Br)c2[nH]c3c(c2c1)CN1CCC3CC1,,CC(=O)O,Cl,,,val
US20160137696A1,CN(C)C(OC(C)(C)C)OC(C)(C)C.O=C(O)CCCCCCCCCCCCCCC(=O)O>>CC(C)(C)OC(=O)CCCCCCCCCCCCCCC(=O)O,,Cc1ccccc1,,,,val
US05256675,CC(=O)Nc1ncc(Cl)s1.Oc1ccc(S)cc1>>CC(=O)Nc1ncc(Sc2ccc(O)cc2)s1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020013316A1,COC(=O)c1nc(N)cnc1OC.N>>COc1ncc(N)nc1C(N)=O,,CO,,,,val
US07005440B1,CN.COCCOCOc1cccc(C=O)c1>>CNCc1cccc(OCOCCOC)c1,[Pd],C1CCOC1,,,,val
US05753663,CCOC(=O)Cl.COc1cc(N)cc(OC)c1OC>>CCOC(=O)Nc1cc(OC)c(OC)c(OC)c1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20100292238A1,CC1(C)OC(c2ccc(OCc3ccccc3)cc2)=C(c2ccncc2)C1=O>>CC1(C)OC=C(c2ccncc2)C1=O,,CO,,,,val
US20140135318A1,CCCCNCCCC.COC(=O)c1ccc(-c2ccnc(Cl)n2)c(C(=O)N2CCc3ccccc3C2)c1>>CCCCN(CCCC)c1nccc(-c2ccc(C(=O)O)cc2C(=O)N2CCc3ccccc3C2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04973592,Cl.O=C(OCCNc1ncccn1)C(O)(c1ccccc1)C1CCCCC1>>Cl.O=C(OCCNC1=NCCCN1)C(O)(c1ccccc1)C1CCCCC1,[Pd],O,,,,val
US04051253,CCCCc1ccccc1C(=O)NN.O=CC=Cc1ccc([N+](=O)[O-])o1>>CCCCc1ccccc1C(=O)NN=CC=Cc1ccc([N+](=O)[O-])o1,,ClCCl,,,,val
US05451601,COc1ccccc1[C@H](C)C(=O)O.F[C@@H]1CCC(c2ccccc2)(c2ccccc2)[C@@H]2CNC[C@H]12>>COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](F)CCC(c3ccccc3)(c3ccccc3)[C@@H]2C1,,CCN(CC)CC,ClCCl,Cl,O=C(n1ccnc1)n1ccnc1,val
US20150057271A1,COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(c2)OCCN3c2ccccc2-c2cncnc2)cc1>>O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCCN2c1ccccc1-c1cncnc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070232612A1,CCI.N#Cc1ccc(-c2ccc(N3CC[C@@H]4CNC[C@@H]43)cc2)cc1>>CCN1C[C@H]2CCN(c3ccc(-c4ccc(C#N)cc4)cc3)[C@H]2C1,,C1CCOC1,O,[H-].[Na+],,val
US04939261,COC(=O)CCCNC(=O)C(CCC(=O)OC)CCc1ccccc1>>O=C(O)CCCNC(=O)C(CCC(=O)O)CCc1ccccc1,,CO,,Cl,[Na+].[OH-],val
US20140249126A1,CCn1cc(C(=O)O)c(=O)c2ccc(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)c21.NCCN1CCCC1>>CCn1cc(C(=O)NCCN2CCCC2)c(=O)c2ccc(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)c21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080194618A1,BrCCCCOCc1ccccc1.OC(c1ccccc1)(c1ccccc1)C12CCN(CC1)C2>>OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCCOCc3ccccc3)(CC1)C2.[Br-],,CC#N,,,,val
US20070123515A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc3[nH]c(C(=O)N4CCC(F)(F)CC4)cc3c2)CC1>>O=C(c1cc2cc(OC3CCNCC3)ccc2[nH]1)N1CCC(F)(F)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04465508,CCOC(=O)c1cc(Cl)ccc1[N+](=O)[O-].Oc1cc(Cl)c(Cl)cc1Cl>>CCOC(=O)c1cc(Oc2cc(Cl)c(Cl)cc2Cl)ccc1[N+](=O)[O-],,CC(=O)N(C)C,,[H-].[Na+],,val
US04764519,CCOC(=O)C(CC#N)(C(=O)OCC)c1ncc([N+](=O)[O-])cc1C>>Cc1cc([N+](=O)[O-])cnc1CCC#N,,CO,,Cl,[Na+].[OH-],val
US04357282,COC(F)(F)C(F)(F)C(N)=O>>COC(F)(F)C(F)(F)C#N,,COCCOCCOC,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US04954164,CCOC=C(C(=O)OCC)C(=O)OCC.CNN>>CCOC(=O)c1cnn(C)c1O,,CCO,,,,val
US20110003839A1,N#Cc1ncc([N+](=O)[O-])cc1C(F)(F)F.S=C(Cl)Cl>>N#Cc1ncc(N=C=S)cc1C(F)(F)F,,O,,,,val
US20080132551A1,CCCC[Sn](CCCC)(CCCC)c1ccco1.CCOc1ccc(N)c(Br)c1>>CCOc1ccc(N)c(-c2ccco2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20080251169A1,Nc1nc[nH]n1.O=C(O)C(F)(F)F>>Nc1nc[nH+][nH]1.O=C([O-])C(F)(F)F,,O,,,,val
US20090197935A1,Cn1ncc(Br)c1-c1cc(N)ccc1OCC(C)(C)NC(=O)OC(C)(C)C.O=C(Cl)c1ccc(F)cc1>>Cn1ncc(Br)c1-c1cc(NC(=O)c2ccc(F)cc2)ccc1OCC(C)(C)N,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US06946478B2,CC(C)(C)OC(=O)NCCN1CCC(Nc2ccc(Cl)c(Cl)c2)CC1>>NCCN1CCC(Nc2ccc(Cl)c(Cl)c2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150087646A1,N#Cc1ccc(I)c(F)c1.OO>>NC(=O)c1ccc(I)c(F)c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090299060A1,CNC.O=C(Nc1ccc(Cl)cc1C(=O)c1ccccc1CBr)c1ccccc1>>CN(C)Cc1ccccc1C(=O)c1cc(Cl)ccc1N,,ClCCl,O,[K+].[OH-],,val
US20100286211A1,Brc1ccc(Br)nc1.c1cncc(-c2c[nH]cn2)c1>>Brc1ccc(-n2cnc(-c3cccnc3)c2)nc1,,CN1CCCC1=O,CO,O,,val
US20040092582A1,COc1cccc2ccoc12>>COc1cccc2c1OCC2,[Pd],CC(=O)O,,,,val
US04788130,COc1ccc(C=C2Cc3c(C)cc(C)c(O)c3C2=O)cc1>>COc1ccc(CC2Cc3c(C)cc(C)c(O)c3C2=O)cc1,[Pd],CC(=O)O,CCOC(C)=O,[H][H],,val
US04908386,CC(=O)Nc1ccc(CCOCCCCCCNCc2ccccc2)cc1.O=C(CBr)c1cccc(O)c1>>CC(=O)Nc1ccc(CCOCCCCCCN(CC(=O)c2cccc(O)c2)Cc2ccccc2)cc1,,ClCCl,O,,,val
US20070135441A1,COCCOCCBr.O=C(c1ccc(-c2ccc(O)nn2)cc1)N1CCN(S(=O)(=O)c2cc3cc(Cl)ccc3[nH]2)CC1>>COCCOCCn1nc(-c2ccc(C(=O)N3CCN(S(=O)(=O)c4cc5cc(Cl)ccc5[nH]4)CC3)cc2)ccc1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06489487B1,COc1n[nH]c(=O)[nH]1.O=Cc1cccc(CBr)c1>>COc1n[nH]c(=O)n1Cc1cccc(C=O)c1,,CC#N,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US04147872,Br[Mg]CCCc1ccccc1.CCCCCCC(C)(C)c1ccc(C2CN(Cc3ccccc3)CCC2=O)c(OCc2ccccc2)c1>>CCCCCCC(C)(C)c1ccc(C2CN(Cc3ccccc3)CCC2(O)CCCc2ccccc2)c(OCc2ccccc2)c1,,CCOCC,,C1CCOC1,[Cl-].[NH4+],val
US05763460,C[C@@H]1COS(=O)(=O)N1c1ccccn1.OC1(c2cccs2)CCNCC1>>C[C@H](CN1CC=C(c2cccs2)CC1)Nc1ccccn1,,CN(C)C=O,,,,val
US20120010235A1,CCOC(=O)CN=C=O.COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F>>CCOC(=O)CNC(=O)N1[C@@H](C(=O)Nc2ccc(C(=O)O)cc2OC)[C@H](c2cccc(Cl)c2F)[C@@](C#N)(c2ccc(Cl)cc2F)[C@@H]1CC(C)(C)C,,ClCCl,,O,,val
US06297255B1,CC(=O)OC1(C(=O)Nc2ccc(-c3sc4c(c3CN(C)Cc3ccccc3)c(=O)c(C(=O)c3ccccc3)cn4Cc3c(F)cccc3F)cc2)CC1>>CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)C3(O)CC3)cc2)sc2c1c(=O)c(C(=O)c1ccccc1)cn2Cc1c(F)cccc1F,,CCO,ClC(Cl)Cl,[Na+].[OH-],,val
US20070043072A1,COC(=O)CCc1cc(C)cc(NC(C)=O)n1>>CC(=O)Nc1cc(C)cc(CCC(=O)O)n1,,CO,O,[Na+].[OH-],,val
US20030105066A1,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.O=[N+]([O-])O>>CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.O=[N+]([O-])[O-],,CC#N,ClC(Cl)Cl,,,val
US03974144,Cc1ccc(-c2cc3cc(C)ccc3o2)cc1.O=Cc1ccc(C(=O)O)cc1>>Cc1ccc2oc(-c3ccc(C=Cc4ccc(C(=O)O)cc4)cc3)cc2c1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20160159809A1,Clc1nc(NCC(c2ccccc2)c2cccnc2)c2ccccc2n1.c1ccc(C(CNc2nc(-c3ccc4nccn4c3)nc3ccccc23)c2ccc[nH]2)cc1>>c1ccc(C(CNc2nc(-c3ccc4[nH]ccc4c3)nc3ccccc23)c2cccnc2)cc1,,CO,ClCCl,,,val
US20130116235A1,CC1(C)Cc2cc3n(c2C1)CCN(c1nccc(Cl)c1C=O)C3=O>>CC1(C)Cc2cc3n(c2C1)CCN(c1nccc(Cl)c1CO)C3=O,,ClCCl,,CO,[BH4-].[Na+],val
US20090253699A1,CC(C)c1ccc(C(N)=O)cc1.ClSC(Cl)(Cl)Cl.O>>CC(C)c1ccc(-c2nsc(=O)o2)cc1,,Cc1ccccc1,,,,val
US06200981B1,CCOP(=O)(Cl)OCC.Cc1cccc(Br)c1>>CCOP(=O)(OCC)c1cccc(C)c1,,C1CCOC1,CCCCC,[Li]C(C)(C)C,,val
US20100105678A1,CCOC(=O)C(=CNc1ccc(NC2Cc3ccccc3C2)nc1)C(=O)OCC>>CCOC(=O)c1c[nH]c2ccc(NC3Cc4ccccc4C3)nc2c1=O,,ClCCl,,c1ccc(Oc2ccccc2)cc1,,val
US20070135461A1,C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C(CC#N)C4CCC(CO)C4)c3)ncnc21>>N#CCC(C1CCC(CO)C1)n1cc(-c2ncnc3[nH]ccc23)cn1,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US20050245741A1,COc1cc(O)c(NC(C)=O)cc1Cl.O=[N+]([O-])c1cccc(S(=O)(=O)OC[C@@H]2CO2)c1>>COc1cc(OC[C@@H]2CO2)c(NC(C)=O)cc1Cl,,CN1CCCC1=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060189604A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C(N)=O)C[C@@H]1OC(=O)c1ccc([N+](=O)[O-])cc1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C(N)=O)C[C@@H]1O,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20100249119A1,CC(C)(C#N)c1cccc(C(=O)Cl)c1.Nc1ccc(C(F)(F)F)c(O)c1>>CC(C)(C#N)c1cccc(C(=O)Nc2ccc(C(F)(F)F)c(O)c2)c1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20070276000A1,CCCCc1cc2cc(OC)ccc2c(Oc2ccc(/C=C/C(=O)O)cc2)c1-c1ccccc1>>CCCCc1cc2cc(O)ccc2c(Oc2ccc(/C=C/C(=O)O)cc2)c1-c1ccccc1,,ClCCl,,BrB(Br)Br,,val
US20050096327A1,Cl.Fc1ccccc1-c1nc(N2CCNCC2)nc2ccccc12>>Cl.Fc1ccccc1-c1nc(N2CCNCC2)nc2ccccc12,,C1CCOC1,,CCOCC,,val
US04159340,C=CCN[C@@H]1CCC[C@H]1Nc1ccc(Cl)c(Cl)c1.O=C(Cl)OCC(Cl)(Cl)Cl>>C=CCN(C(=O)OCC(Cl)(Cl)Cl)[C@@H]1CCC[C@H]1Nc1ccc(Cl)c(Cl)c1.Cl,,CCOCC,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20160168156A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(O)/C=C/c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12>>CC(C)(C)OC(=O)N1CCN(C(=O)/C=C/c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)CC1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05440065,C=CC(CCC(=O)OCC)NC(=O)C(Cl)(Cl)Cl>>C=CC(N)CCC(=O)O,,Cl,,,,val
US04005217,CC(C)OC(=O)Cl.Nc1ccc(N)c([N+](=O)[O-])c1>>CC(C)OC(=O)Nc1ccc(N)c([N+](=O)[O-])c1,,O,,O=C([O-])O.[Na+],,val
US20160200695A1,C#CCOc1ccc2nc(NC(=O)c3ccc(C(=O)c4ccccc4)cc3)sc2c1>>CCCOc1ccc2nc(NC(=O)c3ccc(C(=O)c4ccccc4)cc3)sc2c1,[Pd],CCOC(C)=O,,[H][H],,val
US04582945,C#CC1(O)C2(C)CCCC1(C)CC2>>CCC1(O)C2(C)CCCC1(C)CC2,[Ni],,,[H][H],,val
US20100029611A1,COC(=O)C1CN(Cc2ccc(-c3nc4ccc(C5(c6ccccc6)CC=CC5)nc4s3)c(F)c2)C1>>COC(=O)C1CN(Cc2ccc(-c3nc4ccc(C5(c6ccccc6)CCCC5)nc4s3)c(F)c2)C1,[Pd],C1CCOC1,,CO,O,val
US20150028321A1,CC(C)(C)c1ccnc(Cl)c1.OB(O)c1cccc(Cl)c1>>CC(C)(C)c1ccnc(-c2cccc(Cl)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[K+].[K+],val
US20070043064A1,CN(C)/C=C/C(=O)c1cccs1.Nc1[nH]ncc1[N+](=O)[O-]>>O=[N+]([O-])c1cnn2c(-c3cccs3)ccnc12,,CC(=O)O,,CCOC(C)=O,,val
US20140228360A1,O=[N+]([O-])c1cccc(S(=O)(=O)OC[C@@H]2CO2)c1.c1ccc2c(c1)CNC2>>c1ccc2c(c1)CN(C[C@@H]1CO1)C2,,C1CCOC1,,[F-].[K+],,val
US20040063170A1,COC(=O)c1ccc(Cc2ccccc2O[C@@H]2O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)cc1>>COC(=O)c1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1,,CO,,C[O-].[Na+],,val
US07629358B2,CC(C)(Cc1cccc(CC(=O)O)c1)NC(=O)CCl.CO>>COC(=O)Cc1cccc(CC(C)(C)N)c1,,CO,,CC(=O)Cl,,val
US03965143,C#CCC(O)CCCC.COCCOC>>C#CCC(CCCC)OC,,CCCCCC,CCOCC,[Li]CCCC,,val
US20090005374A1,CCOC(=O)c1cccc(Nc2nc(-c3c(C)nc4ccccn34)cs2)c1.NO>>Cc1nc2ccccn2c1-c1csc(Nc2cccc(C(=O)NO)c2)n1,,CO,,ClCCl,[Na+].[OH-],val
US20120172333A1,O=c1[nH]c2ccn(-c3ccc(Br)cc3)c2c(O)c1-c1ccccc1.OB(O)c1ccccc1O>>O=c1[nH]c2ccn(-c3ccc(-c4ccccc4O)cc3)c2c(O)c1-c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160009712A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cn1c(=O)oc2cc(Br)cnc21>>Cn1c(=O)oc2cc(B3OC(C)(C)C(C)(C)O3)cnc21,,C1COCCO1,,ClCCl,CC(=O)[O-].[K+],val
US20150080438A1,CN.O=S(=O)(CCCCCl)CCCC(F)(F)F>>CNCCCCS(=O)(=O)CCCC(F)(F)F,,CCO,,,,val
US03962249,C[C@H]1[C@H](C)NCCN1CCCc1ccccc1.O=C(Cl)c1ccco1>>C[C@H]1[C@H](C)N(C(=O)c2ccco2)CCN1CCCc1ccccc1,,c1ccccc1,,,,val
US03940259,Cc1ccc(Cl)cc1N.ClCC1OCCO1>>Cc1ccc(Cl)cc1NCC1OCCO1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070015812A1,CC(C)(C)OC(=O)N1Cc2cccnc2CC1C(=O)Nc1ccc(-n2ccccc2=O)cc1F>>O=C(Nc1ccc(-n2ccccc2=O)cc1F)C1Cc2cccnc2CN1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20090042841A1,COCCO.Cc1cccc(C#CC=C2CCNCC2)n1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COCCOC(=O)N1CCC(=CC#Cc2cccc(C)n2)CC1,,ClCCl,,,,val
US20050234265A1,COc1cc(C(C)(C)C)cc(C(C)(C)C)c1Br.OB(O)c1ccc(Cl)cc1>>COc1cc(C(C)(C)C)cc(C(C)(C)C)c1-c1ccc(Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,[Na+].[OH-],,val
US05707991,O=C(NCC(=O)N1C(C(=O)N2CCCc3ccccc32)CC(S(=O)(=O)c2ccccc2)C1c1ccccc1F)Nc1cccc(CC(=O)OCc2ccccc2)c1>>O=C(O)Cc1cccc(NC(=O)NCC(=O)N2C(C(=O)N3CCCc4ccccc43)CC(S(=O)(=O)c3ccccc3)C2c2ccccc2F)c1,[Pd],CCO,,,,val
US20080194590A1,CCc1cc2c(N3CCN(C(=O)c4ccc(-c5ccccc5)cc4)CC3)nc(NCCC=O)nc2s1.O=C(OO)c1cccc(Cl)c1>>CCc1cc2c(N3CCN(C(=O)c4ccc(-c5ccccc5)cc4)CC3)nc(NCCC(=O)O)nc2s1,,ClCCl,,,,val
US20060084680A1,CCOC(=O)C[C@@H]1CCc2cc(OCCCNc3nc(-c4ccc(CC)cc4)ccc3C(F)(F)F)ccc21>>CCc1ccc(-c2ccc(C(F)(F)F)c(NCCCOc3ccc4c(c3)CC[C@H]4CC(=O)O)n2)cc1,,C1CCOC1,CO,O,[Li+].[OH-],val
US20080020010A1,ClCc1ccccc1.O=C1C(Br)=CN=CC1Cc1ccccc1>>O=c1c(Br)cn(Cc2ccccc2)cc1Cc1ccccc1,,CCO,,C,C[O-].[Na+],val
US04725600,COc1ccc(-c2cc(=Nc3c(C)cc(C)cc3C)n(C)c(Cl)n2)cc1OC.NNC=O>>COc1ccc(-c2cc(=Nc3c(C)cc(C)cc3C)n(C)c(NNC=O)n2)cc1OC,,ClC(Cl)Cl,,,,val
US20100317568A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.CC(C)(C)OC(=O)N1CCC[C@H]1c1nc(-c2ccc(C3CCC(c4ccc(N)cc4)N3c3ccc(C(C)(C)C)cc3)cc2)c[nH]1>>CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)Nc1ccc(C2CCC(c3ccc(-c4c[nH]c([C@@H]5CCCN5C(=O)OC(C)(C)C)n4)cc3)N2c2ccc(C(C)(C)C)cc2)cc1,,CS(C)=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140155391A1,CCOC(=O)c1ccc(OC(F)(F)F)c([N+](=O)[O-])c1>>COC(=O)c1ccc(OC(F)(F)F)c(N)c1,[Pd],CO,,,,val
US20070021473A1,CCCCNCCCOc1ccc(-c2ccc(C(=O)OCC)cc2)cc1-c1ccc2c(c1)C(C)(C)CCC2(C)C>>CCCCNCCCOc1ccc(-c2ccc(C(=O)O)cc2)cc1-c1ccc2c(c1)C(C)(C)CCC2(C)C,,C1CCOC1,,[Na+].[OH-],,val
US05834463,NCC1CC(=O)N(Cc2ccccc2)c2ccccc2N1.O=C(Cl)OCc1ccccc1>>NC(C(=O)OCc1ccccc1)C1CC(=O)N(Cc2ccccc2)c2ccccc2N1,,ClCCCl,,O=C([O-])O.[Na+],,val
US20150225412A1,CC(C)(C)OC(=O)N1CCC[C@@H]1Cn1c(NC(=O)c2ccc(C(F)F)s2)nc2cc(CO)ccc21>>O=C(Nc1nc2cc(CO)ccc2n1C[C@H]1CCCN1)c1ccc(C(F)F)s1,,C1COCCO1,ClCCl,Cl,,val
US20070093544A1,CCCCOC(=O)c1ccc2c(c1)CCC2N(c1nc2cc(O)ccc2n1C)[C@@H]1CC[C@@H](C(C)(C)C)CC1.CCCO>>CCCCOC(=O)c1ccc2c(c1)CCC2N(c1nc2cc(OCCC)ccc2n1C)[C@@H]1CC[C@@H](C(C)(C)C)CC1,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120270893A1,COC1c2nn(C(C)(C)C)cc2CC2(CCN(C(=O)OCc3ccccc3)CC2)C1Br>>CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)OCc3ccccc3)CC1)C2,,C1CCOC1,O,Cl,CC(C)(C)[O-].[K+],val
US20130065923A1,Cc1nc(N2CC[C@H](N3CCC[C@@H]3C)C2)ccc1N.O=C(Cl)c1cccc2ccccc12>>Cc1nc(N2CC[C@H](N3CCC[C@@H]3C)C2)ccc1NC(=O)c1cccc2ccccc12,,ClCCl,c1ccncc1,,,val
US04317914,CC1(C)N=C1c1ccccc1.Cc1cc(C=O)cc(C)c1N(C)C>>Cc1cc(C2OC(C)(C)N=C2c2ccccc2)cc(C)c1N(C)C,,C1COCCO1,,,,val
US20130096113A1,CC(=O)c1ccn2c(Cc3ccc4nc(N[C@@H]5CCCC[C@H]5O)sc4c3)cnc2c1.NO>>CC(=NO)c1ccn2c(Cc3ccc4nc(N[C@@H]5CCCC[C@H]5O)sc4c3)cnc2c1,,CCO,,Cl,c1ccncc1,val
US20150218150A1,CC(=O)OC(C)=O.O=S(=O)(c1ccccc1)n1ccc2cc(Br)ccc21>>CC(=O)c1cn(S(=O)(=O)c2ccccc2)c2ccc(Br)cc12,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05073641,CN(C)C(=O)CCl.Cc1cccc(Nc2ccccc2C(=O)O)c1C>>Cc1cccc(Nc2ccccc2C(=O)OCC(=O)N(C)C)c1C,,CN(C)C=O,O,CCN(CC)CC,[I-].[Na+],val
US05225402,O=C(c1ccccc1)N1CCC(n2c(=O)ccc3ccccc32)CC1>>O=c1ccc2ccccc2n1C1CCNCC1,,CCO,,[Na+].[OH-],,val
US20160221945A1,CC(C)OB(OC(C)C)OC(C)C.Fc1cc(Br)ccc1OC(F)(F)F>>OB(O)c1ccc(OC(F)(F)F)c(F)c1,,C1CCOC1,,[Li]CCCC,,val
US20120083513A1,Cn1nnc2c(C(=O)Nc3ccccc3N)ncn2c1=O>>Cn1nnc2c(-c3nc4ccccc4[nH]3)ncn2c1=O,,Cl,,,,val
US20110098296A1,CC(=O)N(C)C.CN(C)CCCNc1ccc(N)cc1F.O=C(Cc1ccnc(Cl)n1)c1cccc(NC(=O)c2cc(F)ccc2F)c1>>CN(C)CCCNc1ccc(Nc2nccc(CC(=O)c3cccc(N(C)C(=O)c4cc(F)ccc4F)c3)n2)cc1F,Cl,CC(=O)N(C)C,,CC(C)O,,val
US20040259873A1,CC(=O)OC=O.CCOc1cc([C@@H](CCNO)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC>>CCOc1cc([C@@H](CCN(O)C=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC,,ClCCl,,,,val
US20160168122A1,O=Cc1c(Cl)cccc1-n1ccc2cc(C3CC3)cc(F)c2c1=O>>O=c1c2c(F)cc(C3CC3)cc2ccn1-c1cccc(Cl)c1CO,,CC(C)O,ClCCl,O,[BH4-].[Na+],val
US04371736,Clc1cnc(Cl)nc1.Oc1ccccc1O>>Oc1ccccc1Oc1ncc(Cl)cn1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20020119992A1,CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)NCc1cc(Cl)ccc1CC(N)C(F)F)C1CCCCC1>>NC(Cc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)[C@H](N)C1CCCCC1)C(F)F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060241115A1,COc1cc2nccc(Cl)c2cc1OC.Cl.O=C(O)c1cccc2cc(O)ccc12>>COc1cc2nccc(Oc3ccc4c(C(=O)O)cccc4c3)c2cc1OC.Cl,,CS(C)=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US07820825B2,CCn1c(Cc2ccc(C(=O)N3CCC(N4CCCC4)C3)cc2)nc2ccccc21>>CCn1c(Cc2ccc(CN3CC[C@H](N4CCCC4)C3)cc2)nc2ccccc21,,C1CCOC1,,B,,val
US06211177B1,CCOC(=O)c1ccc2c(c1)nc(Cc1ccccc1)n2Cc1ccc(Cl)cc1Cl>>O=C(O)c1ccc2c(c1)nc(Cc1ccccc1)n2Cc1ccc(Cl)cc1Cl,,CCO,,Cl,[Na+].[OH-],val
US20130005689A1,O=C(Cl)OCCl.O=C(NCc1ccc(-c2cc[nH]c(=O)c2)cc1)c1c(Cl)cccc1Cl>>O=C(NCc1ccc(-c2ccn(CCl)c(=O)c2)cc1)c1c(Cl)cccc1Cl,,CCOC(C)=O,,CN(C)C=O,,val
US20130023541A1,CC(C)(C)OC(=O)N1CCC[C@H]1CO.CC(C)OC(=O)c1cccnc1O>>CC(C)OC(=O)c1cccnc1OC[C@@H]1CCCN1C(=O)OC(C)(C)C,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04188390,COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC.COc1ccc2c(c1)OCC(C(=O)Cl)O2.O=S(Cl)Cl>>COc1ccc2c(c1)OCC(C(=O)N1CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)CC1)O2.Cl.O,,ClCCl,ClCCl,,,val
US20090170849A1,FC(F)(F)C1CCCC([NH2+]Cc2ccccc2)C1.[Cl-]>>[Cl-].[NH3+]C1CCCC(C(F)(F)F)C1,[Pd],CO,,,,val
US20080139597A1,CCN(CC)C(=O)CCc1ccc(Nc2ncc(-c3ccc(OC)cc3)cn2)cc1>>CCN(CC)CCCc1ccc(Nc2ncc(-c3ccc(OC)cc3)cn2)cc1,,CO,,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US04335142,O=S(=O)(c1ccccc1)C(CCl)Sc1ccc(Br)cc1>>C=C(Sc1ccc(Br)cc1)S(=O)(=O)c1ccccc1,,C1CCOC1,CCOCC,CCN(CC)CC,,val
US20090036453A1,COc1ccc(Br)cc1O.ClCCBr>>COc1ccc(Br)cc1OCCCl,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20030220348A1,COc1cnc(CCl)c(OC)n1.c1c[nH]c(-c2nccs2)n1>>COc1cnc(Cn2ccnc2-c2nccs2)c(OC)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060281767A1,COC(=O)CC(=O)OC.Clc1cncnc1Cl>>COC(=O)C(C(=O)OC)c1ncncc1Cl,,C1CCOC1,,Cl,[H-].[Na+],val
US20020133023A1,COC(=O)/C=C/CBr.c1ccc(CN2CCNCC2)cc1>>COC(=O)C=CCN1CCN(Cc2ccccc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160244410A1,COc1ccc(Cn2c(=O)c3c(OS(=O)(=O)C(F)(F)F)cc(=O)n(C)c3n(-c3ccc(I)cc3F)c2=O)cc1.Cc1c(O)cccc1O>>COc1ccc(Cn2c(=O)c3c(Oc4cccc(O)c4C)cc(=O)n(C)c3n(-c3ccc(I)cc3F)c2=O)cc1,,C1CCOC1,,[H-].[Na+],,val
US20030004353A1,O=C(NCC#Cc1ccc(C#CCNC(=O)OCc2ccccc2)nc1)OCc1ccccc1>>NCCCc1ccc(CCCN)nc1,,CO,,[H][H],,val
US20080058335A1,COCCn1c(C)c(C)sc1=N.O=C(Cl)c1c(Cl)cccc1Cl>>COCCn1c(C)c(C)s/c1=N\C(=O)c1c(Cl)cccc1Cl,,C1CCOC1,,CCN(CC)CC,,val
US20070078156A1,CI.Cc1cccc(F)c1C(=O)O.O=[N+]([O-])O>>COC(=O)c1c(F)ccc(N)c1C,,O=S(=O)(O)O,,O,O=C([O-])[O-].[K+].[K+],val
US20100249085A1,CC(C)(F)c1ccc(C(N)=NO)cc1.Cc1cc(C(=O)O)n[nH]1>>Cc1cc(-c2nc(-c3ccc(C(C)(C)F)cc3)no2)n[nH]1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20080207635A1,CN1CCN(CCc2ccc(NC(=O)c3cccc([N+](=O)[O-])c3N)cc2)CC1>>CN1CCN(CCc2ccc(NC(=O)c3cccc(N)c3N)cc2)CC1,[Pd],CO,,,,val
US20060281772A1,CC(C)(C)OC(=O)N1CCC(c2ncnc3cc(F)ccc23)CC1.NCCNC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC(c2ncnc3cc(N4CCNC4=O)ccc23)CC1,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20160159815A1,COc1cc(C(=O)N2CC[C@@](O)(c3cccc(Br)n3)[C@H](O)C2)ccc1OCCOC(F)(F)F>>COc1cc(C(=O)N2CC[C@@](O)(c3ccccn3)[C@H](O)C2)ccc1OCCOC(F)(F)F,[Pd],CC(C)O,,,,val
US06555541B1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccc(CN2CCN(C(=O)OC(C)(C)C)CC2)cc1NC(=O)CN(C(=O)OC(C)(C)C)c1ccc(F)c(F)c1>>Cc1ccc(CN2CCN(C(=O)OC(C)(C)C)CC2)cc1NC(=S)CN(C(=O)OC(C)(C)C)c1ccc(F)c(F)c1,,Cc1ccccc1,,,,val
US20140256715A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@@]1(C(F)(F)F)OC[C@@](C)(c2nc(Br)ccc2F)N=C1N>>CC(C)(C)OC(=O)NC1=N[C@](C)(c2nc(Br)ccc2F)CO[C@@]1(C)C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06432993B1,COCCl.Cc1cc(OC(=O)C(C)(C)C)cc(C)c1O>>COCOc1c(C)cc(OC(=O)C(C)(C)C)cc1C,,O,,C1CCOC1,[H-].[Na+],val
US20120277220A1,CC(C)(C)OC(=O)NCCCn1c(N)c(C(N)=O)c(=O)c2cnc(Cl)nc21.Nc1ccc(N2CCOCC2)cc1>>CC(C)(C)OC(=O)NCCCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(N4CCOCC4)cc3)nc21,,CN1CCCC1=O,,O,O=C([O-])O.[Na+],val
US20050250766A1,Cn1c(C#N)ccc1-c1ccc2c(c1)C1(CCCCC1)C(=NC#N)N2>>Cn1c(C#N)ccc1-c1ccc2c(c1)C1(C=N2)CCCCC1,,C1CCOC1,,CCNCC,,val
US20060135530A1,C=CC(=O)OCC.Cc1ccc(-c2c(CNC(=O)OC(C)(C)C)c(CC(C)C)nc3ccc(OS(=O)(=O)C(F)(F)F)cc23)cc1>>CCOC(=O)/C=C/c1ccc2nc(CC(C)C)c(CNC(=O)OC(C)(C)C)c(-c3ccc(C)cc3)c2c1,,CN(C)C=O,,CCN(CC)CC,O,val
US04735959,CCOC(=O)c1ccc(CC#N)cc1.Cc1cccc(C(O)c2ccccc2N2CCCCC2)c1>>CCOC(=O)c1ccc(CC(=O)NC(c2cccc(C)c2)c2ccccc2N2CCCCC2)cc1,,Clc1ccccc1Cl,,O=S(=O)(O)O,,val
US20120184747A1,BrCc1ccccc1.CNc1ccc(CC(NS(=O)(=O)c2cccnc2)c2cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)cc1>>CN(Cc1ccccc1)c1ccc(CC(NS(=O)(=O)c2cccnc2)c2cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)cc1,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US06437138B1,CC(C)(C)OC(=O)N1CC[C@H]1COc1cnc(Cl)c(C(=O)c2ccccc2)c1>>O=C(c1ccccc1)c1cc(OC[C@@H]2CCN2)cnc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US05698554,CC(CCN1C(=O)c2ccccc2C1=O)Cc1ccccc1.O=C1CCC(=O)O1>>CC(CCN1C(=O)c2ccccc2C1=O)Cc1ccc(C(=O)CCC(=O)O)cc1,,CC(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20150232435A1,CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.CCN1CCNCC1.O=C(n1ccnc1)n1ccnc1>>CCN1CCN(C(=O)NCCCCN2CCN(c3cc(C(F)(F)F)nc(C(C)(C)C)n3)CC2)CC1,,CO,ClC(Cl)Cl,,,val
US06534135B1,C=CCCCBr.CC[C@H](C)COc1ccc(C=O)c(O)c1OC[C@@H](C)CC>>C=CCCCOc1c(C=O)ccc(OC[C@@H](C)CC)c1OC[C@@H](C)CC,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060154928A1,CCCCCCCCCCCCC=O.Cl.N=C(N)NC(=N)NCc1ccccc1>>CCCCCCCCCCCCC1N=C(N)NC(NCc2ccccc2)=N1.Cl,,CCO,,Cl,,val
US20030060466A1,N#CC1(c2ccccc2)CCNCC1.N#Cc1c(Cl)nc(NCCO)nc1NCCO>>N#Cc1c(NCCO)nc(NCCO)nc1N1CCC(C#N)(c2ccccc2)CC1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20080221197A1,CC(C)(C)c1ccccc1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12>>CC(C)(C)c1ccccc1-c1c[nH]c2ccccc12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050245524A1,CS(=O)(=O)Nc1cccc(B(O)O)c1.Cc1cc(Br)cc2nnc(N)nc12>>Cc1cc(-c2cccc(NS(C)(=O)=O)c2)cc2nnc(N)nc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20140038975A1,C[C@@](CCn1cc(C#Cc2cccc(C#N)c2)cn1)(C(=O)NOC1CCCCO1)S(C)(=O)=O>>C[C@@](CCn1cc(C#Cc2cccc(C#N)c2)cn1)(C(=O)NO)S(C)(=O)=O,,CCO,,Cl,,val
US20130085132A1,C[C@@H](O)C(F)(F)F.OB(O)c1cccc(CBr)c1>>C[C@@H](Oc1cccc(B(O)O)c1)C(F)(F)F,,CN(C)C=O,,O,[H-].[Na+],val
US20090298807A1,COc1ccc(CC(=O)O)c(F)c1F>>O=C(O)Cc1ccc(O)c(F)c1F,,ClCCl,,BrB(Br)Br,,val
US04840971,CCOc1ccc(C(CO)C(F)(F)F)cc1.Clc1ccc(Oc2cccc(CBr)c2)cc1>>CCOc1ccc(C(COCc2cccc(Oc3ccc(Cl)cc3)c2)C(F)(F)F)cc1,,C1CCOC1,,[H-].[Na+],,val
US20090048258A1,COCOc1ccc([Mg]Br)cc1.O=C1CCC(=O)O1>>COCOc1ccc(C(=O)CCC(=O)O)cc1,,C1CCOC1,,Cl,,val
US20060063739A1,Cc1cccc(C=NNc2cc(N3CCOCC3)nc(CCOS(C)(=O)=O)n2)c1.Sc1nnc(-c2ccncc2)[nH]1>>Cc1cccc(C=NNc2cc(N3CCOCC3)nc(CCSc3nnc(-c4ccncc4)[nH]3)n2)c1,,C1CCOC1,,[H-].[Na+],,val
US20110034455A1,N.O=C(O)CC1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2c(Br)cccc21>>NC(=O)CC1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2c(Br)cccc21,,C1COCCO1,,,,val
US20040220225A1,NCCCN1CCCC1.O=C=NC1CCCCC1>>O=C(NCCCN1CCCC1)NC1CCCCC1,,CC#N,,,,val
US20040127576A1,CN(C)C=O.COc1cccc(I)c1>>COc1ccc(C=O)c(I)c1,,ClCCl,,CCOCC,[Na+].[OH-],val
US05578620,CCC(=O)COc1ccc(CC2SC(=O)N(C(c3ccccc3)(c3ccccc3)c3ccccc3)C2=O)cc1>>CCC(=O)COc1ccc(CC2SC(=O)NC2=O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100305104A1,COCC1CCCN1.Cc1cc(C#N)cnc1F>>COCC1CCCN1c1ncc(C)cc1C#N,,CCCCO,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20100022550A1,COc1ccccc1Cn1c2c(c3cc(Cl)ccc31)CC(NC(=O)C(C)C)CC2>>CC(C)C(=O)NC1CCc2c(c3cc(Cl)ccc3n2Cc2ccccc2O)C1,,ClCCl,,BrB(Br)Br,,val
US20100105679A1,C[Si](C)(C)C(F)(F)F.O=Cc1cc(Br)ccc1F>>OC(c1cc(Br)ccc1F)C(F)(F)F,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080227770A1,CC(=O)O.CCOC(=O)CCC(=O)C(=NO)C(=O)OCC>>CCOC(=O)CCC(=O)C(NC(C)=O)C(=O)OCC,[Zn],CC(=O)O,,CC(=O)OC(C)=O,,val
US20110034441A1,CCC(N)CC.O=C(O)c1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1>>CCC(CC)NC(=O)c1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20110251190A1,CC(C)(C)COc1ccc2c(c1)C1(CC(F)(F)C(=S)N1)c1cc(-c3cncnc3)ccc1O2.N>>CC(C)(C)COc1ccc2c(c1)C1(CC(F)(F)C(N)=N1)c1cc(-c3cncnc3)ccc1O2,Cl[Hg]Cl,C1CCOC1,,,,val
US06288073B1,COc1cc2c(c3c1c(=O)c1cc4ccccc4cc1n3C)C=CC(C)(C)O2.O=[Mn](=O)(=O)[O-]>>COc1cc2c(c3c1c(=O)c1cc4ccccc4cc1n3C)C(=O)C(O)C(C)(C)O2,,CC(C)=O,,O,,val
US20040214852A1,COCCO[C@@H]1c2ccn3cc(C)nc3c2N(C(C)=O)[C@H](c2ccccc2)[C@H]1OC(=O)C(C)(C)C.O=C1CCC(=O)N1Cl>>COCCO[C@@H]1c2ccn3c(Cl)c(C)nc3c2N(C(C)=O)[C@H](c2ccccc2)[C@H]1OC(=O)C(C)(C)C,,CCO,,,,val
US20090176732A1,CCOC(=O)C(CO)(CO)C(=O)OCC.CCOC(C)(OCC)OCC>>CCOC(=O)C1(C(=O)OCC)COC(C)(OCC)OC1,,C1CCOC1,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US04294960,CCO.CON=C(C(=O)NC1C(=O)N2C(C(=O)[O-])=CCS[C@H]12)c1csc(N)n1.O.[Na+]>>CON=C(C(=O)NC1C(=O)N2C(C(=O)[O-])=CCS[C@H]12)c1csc(N)n1.O.O.[Na+],,O,,,,val
US20110021531A1,CC(=O)c1ccc(-c2nc(C3CC3)oc2Sc2ccc(Cl)cn2)cn1>>CC(O)c1ccc(-c2nc(C3CC3)oc2Sc2ccc(Cl)cn2)cn1,,CO,,[BH4-].[Na+],,val
US20080214529A1,COC(=O)C1CCCN1N=CCC(C)C>>COC(=O)C1CCCN1NCCC(C)C,CC(=O)O,CO,,[BH3-]C#N.[Na+],,val
US08431695B2,CC(C)(C)OC(=O)N1CCN2CC(c3cc(-c4ccc5cn(Cc6ccccc6)nc5c4)c4c(N)ncnn34)OCC2C1>>Nc1ncnn2c(C3CN4CCNCC4CO3)cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c12,,ClCCl,O=C(O)C(F)(F)F,,,val
US06100260,CC(c1ccc(-c2ccccc2)c(F)c1)c1cc(NC(N)=S)on1.CI>>CSC(=N)Nc1cc(C(C)c2ccc(-c3ccccc3)c(F)c2)no1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130116289A1,CC(C)(C)OC(=O)CNC(CO[Si](C)(C)C(C)(C)C)c1ccc(C#N)cc1.NO>>CC(C)(C)OC(=O)CNC(CO[Si](C)(C)C(C)(C)C)c1ccc(C(N)=NO)cc1,,CCO,,,,val
US06174901B1,CCOC(=O)CC(C(=O)c1ccc(F)cc1)c1ccncc1.NN>>O=C1CC(c2ccncc2)C(c2ccc(F)cc2)=NN1,,CCO,,O,,val
US20100298336A1,Cc1cc(O)nc(S)n1.FC(F)(F)c1ncccc1CBr>>Cc1cc(O)nc(SCc2cccnc2C(F)(F)F)n1,,CCO,,CCN(CC)CC,,val
US20150011579A1,COC(=O)c1cc(-c2cc(C(=O)O)c3c(-c4ccccc4)nn(C4CCCCO4)c3n2)ccc1F>>COC(=O)c1cc(-c2cc(C(=O)O)c3c(-c4ccccc4)n[nH]c3n2)ccc1F,,C1COCCO1,ClCCl,Cl,O,val
US20020107251A1,Nc1cccc(-n2c(=O)c(Cc3ccccc3)nc3cccnc32)c1.O=S(=O)(Cl)Cc1ccccc1>>O=c1c(Cc2ccccc2)nc2cccnc2n1-c1cccc(NS(=O)(=O)Cc2ccccc2)c1,,C1COCCO1,O,CCOC(C)=O,c1ccncc1,val
US20120064004A1,CCOC(=O)N1C(=O)c2ccccc2C1=O.NC(=O)CC[C@H](N)C(=O)O>>NC(=O)CC[C@@H](C(=O)O)N1C(=O)c2ccccc2C1=O,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20090233955A1,CC1(C)OB(c2ccc(CC(=O)O)cc2)OC1(C)C.CO>>COC(=O)Cc1ccc(B2OC(C)(C)C(C)(C)O2)cc1,Cl,,,,,val
US20090209571A1,Brc1cccc(Br)c1-c1nc2c3cccnc3c3ccccc3c2[nH]1.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1cccc2c3nc(-c4c(Br)cccc4Br)[nH]c3c3ccccc3c21,,ClCCl,,,,val
US20160115146A1,CCOC=C(C(=O)OCC)C(=O)OCC.O=C(Nc1cccc(O)c1)c1ccccc1>>O=C(Nc1ccc2cc(C(=O)O)c(=O)oc2c1)c1ccccc1,Cl[Ti](Cl)(Cl)Cl,C1CCOC1,,O,,val
US20140094474A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.COC(=O)c1cn(COCC[Si](C)(C)C)c(Br)n1>>C=C(OCC)c1nc(C(=O)OC)cn1COCC[Si](C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,,,val
US06399627B1,C/C(=C(\F)C(=O)Nc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1)c1cccc(C#N)c1.CC(=O)OCBr>>COC(=O)CN(C(=O)/C(F)=C(/C)c1cccc(C#N)c1)c1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04957917,BrC(Br)(Br)Br.C[Si](C)(C)c1cc(C=O)co1>>C[Si](C)(C)c1cc(C=C(Br)Br)co1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100120798A1,Cn1cc(-c2cccc(C3(CCCN)CCN(c4ncnc5c4ncn5C4CCCCO4)CC3)c2)cn1>>Cn1cc(-c2cccc(C3(CCCN)CCN(c4ncnc5[nH]cnc45)CC3)c2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05247042,Cc1ccc(S(=O)(=O)C(F)(F)F)cc1.O=C1CCC(=O)N1Br>>O=S(=O)(c1ccc(CBr)cc1)C(F)(F)F,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20150218096A1,Clc1cc2c(Br)c[nH]c2cn1.O=C(Cl)c1c(Cl)cccc1C(F)(F)F>>O=C(c1c(Cl)cccc1C(F)(F)F)n1cc(Br)c2cc(Cl)ncc21,,CN(C)C=O,,[H-].[Na+],,val
US20120015975A1,CI.Nc1ccc(OC(F)(F)F)cc1[N+](=O)[O-]>>CNc1ccc(OC(F)(F)F)cc1[N+](=O)[O-],,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20030166697A1,C=CCCCCBr.CCOC(=O)CC(=O)OCC>>C=CCCCCC(C(=O)OCC)C(=O)OCC,,C1CCOC1,,Cl,[H-].[Na+],val
US20030134854A1,COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(Br)c3)nc12.OC1CCCCC1>>COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(OC4CCCCC4)c3)nc12,,C1COCCO1,CN(C)C=O,[H-].[Na+],,val
US20080009490A1,CCOC(=O)C1C2C1N(C(=O)OCc1ccccc1)CC(=O)N2Cc1ccc(F)cc1>>CCOC(=O)CC1CNCC(=O)N1Cc1ccc(F)cc1,[Pd],CCO,,,,val
US20070149557A1,C=C[N+](=O)[O-].Fc1ccc2cc[nH]c2c1>>O=[N+]([O-])CCc1c[nH]c2cc(F)ccc12,,c1ccccc1,,,,val
USRE036256,CC(=O)C(=O)O.COc1ccc(N)cc1OC.O=Cc1cccs1>>COc1cc2cc(C(=O)O)c(-c3cccs3)nc2cc1OC,,CCO,,,,val
US06340749B1,Clc1nc[nH]c1Cl.N#CCCOP(Cl)N1CCCC1>>N#CCCOP(c1nc(Cl)c(Cl)[nH]1)N1CCCC1,,ClCCl,,CCN(CC)CC,,val
US20080188467A1,C=C[Sn](CCCC)(CCCC)CCCC.COCOc1ccc(C=O)cc1Br>>C=Cc1cc(C=O)ccc1OCOC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,Cc1ccccc1,[F-].[K+],,val
US20150005279A1,N#CCN.O=S(=O)(Cl)c1cccc(Br)c1>>N#CCNS(=O)(=O)c1cccc(Br)c1,,c1ccncc1,,Cl,,val
US20090270443A1,CCOCc1nc2c(N(Cc3ccccc3)Cc3ccccc3)nc(C)c(C)c2n1N=C(C)C>>CCOCc1nc2c(N(Cc3ccccc3)Cc3ccccc3)nc(C)c(C)c2n1NC(C)C,,CO,,[BH4-].[Na+],,val
US20130072519A1,COC(=O)Cc1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)c(C(=O)N(C)C)c1>>CN(C)C(=O)c1cc(CC(=O)O)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1,,C1CCOC1,CO,[Li+].[OH-],,val
US20150141644A1,C1COCCN1.COC(=O)c1cc2c(Cl)nc(-c3ccc([N+](=O)[O-])cc3)nn2c1>>COC(=O)c1cc2c(N3CCOCC3)nc(-c3ccc([N+](=O)[O-])cc3)nn2c1,,C1CCOC1,,,,val
US20100152160A1,CCOC(=O)C1(Cc2ccc(F)cc2)CCN(C(=O)C2CN(C(=O)OC(C)(C)C)c3cc(Cl)c(OC)cc3O2)CC1>>CCOC(=O)C1(Cc2ccc(F)cc2)CCN(C(=O)C2CNc3cc(Cl)c(OC)cc3O2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([C@H](O)c4cccc[n+]4[O-])cc2)CCN3)cc1.O=Cc1nccs1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([C@H](O)c4cccc[n+]4[O-])cc2)CCN3Cc2nccs2)cc1,,ClCCCl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120088766A1,CCOC(=O)c1cccc(-c2ccc([N+](=O)[O-])cn2)c1>>CCOC(=O)c1cccc(-c2ccc(N)cn2)c1,[Pd],CCO,,,,val
US03941785,CCC(C)Cc1nc(C)c2c(=O)[nH]c(N)nn12>>CCC(C)Cc1nc(C)c2n1N=C(N)NC2,,COCCOCCOC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150111885A1,CCS(=O)(=O)Cl.COc1cc(F)c(N)cc1Br>>CCS(=O)(=O)Nc1cc(Br)c(OC)cc1F,,ClCCl,,c1ccncc1,,val
US05286728,O=C(CCCl)Nc1ccc(C(=O)N2CCN(CCc3ccc(Cl)cc3)CC2)cc1>>C=CC(=O)Nc1ccc(C(=O)N2CCN(CCc3ccc(Cl)cc3)CC2)cc1,,ClCCl,,CCN(CC)CC,,val
US20090099195A1,CC(C)N1Cc2c(NCc3cnc4ccccc4c3)nc(N3CCNCC3)nc2C1=O.CS(=O)(=O)Cl>>CC(C)N1Cc2c(NCc3cnc4ccccc4c3)nc(N3CCN(S(C)(=O)=O)CC3)nc2C1=O,,ClCCl,,,,val
US04812164,C=CCBr.CCOc1nc(C(F)(F)F)cc(=O)n1-c1cc(O)c(Br)cc1F>>C=CCOc1cc(-n2c(OCC)nc(C(F)(F)F)cc2=O)c(F)cc1Br,,CN(C)C=O,,[H-].[Na+],,val
US20120283094A1,COCCOC.N#CCS(=O)(=O)CCSC(F)(F)F.O=S(=O)(OCCSC(F)(F)F)C(F)(F)F>>CC(C#N)(CCSC(F)(F)F)S(=O)(=O)CCSC(F)(F)F,,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US04147780,CC(C)C=NC(c1ccccc1)c1ccccc1.O=[PH2]O>>CC(C)C(NC(c1ccccc1)c1ccccc1)P(O)O,,CCO,,,,val
US03941782,CCCCCC(C)C(C)c1cc(O)c2c(c1)OC(C)(C)C1=C2CCC1.Cl.O=C(O)CCCN1CCCCC1>>CCCCCC(C)C(C)c1cc(OC(=O)CCCN2CCCCC2)c2c(c1)OC(C)(C)C1=C2CCC1.Cl,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130079335A1,CCOC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(O)ccc2-n2c(C)nnc21.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OS(=O)(=O)C(F)(F)F)ccc2-n2c(C)nnc21,,ClCCl,,c1ccncc1,,val
US05310935,COC(=O)CC1(C)C(=O)N(C)c2ccc(OC)cc21>>COc1ccc2c(c1)C(C)(CC(=O)O)C(=O)N2C,,CO,,[Na+].[OH-],,val
US20090221597A1,Cc1cc(O)nc(N)n1.O=C(Cl)C1(c2ccc3c(c2)OCO3)CC1>>Cc1cc(O)nc(NC(=O)C2(c3ccc4c(c3)OCO4)CC2)n1,,c1ccncc1,,,,val
US20160108046A1,Cc1nc(O)c(Br)cc1[N+](=O)[O-].O=P(Cl)(Cl)Cl>>Cc1nc(Cl)c(Br)cc1[N+](=O)[O-],,O=C([O-])O,[Na+],,,val
US20100240642A1,CCOC(=O)c1c(-c2ccc(OC)nc2)c2ccccc2n1Cc1cccc(-c2ccc(OCc3ccccc3)cc2)c1>>COc1ccc(-c2c(C(=O)O)n(Cc3cccc(-c4ccc(O)cc4)c3)c3ccccc23)cn1,,C1CCOC1,O,[Na+].[OH-],,val
US20040121965A1,CN.Cc1ccc(C(C)(C)C(=O)C(=O)O)cc1>>CN[C@H](C(=O)O)C(C)(C)c1ccc(C)cc1,,C1CCOC1,,,,val
US20150210688A1,COCc1nc(C)c(-c2cc(C(=O)OC)c(C)cc2C)[nH]1>>Cc1cc(C)c(-c2[nH]c(CO)nc2C)cc1C(=O)O,,Br,,,,val
US20110144345A1,CO.COC(OC)OC.O=Cc1ccc(Br)c(O)c1Cl>>COC(OC)c1ccc(Br)c(O)c1Cl,,CO,,Cl,,val
US20030195201A1,CI.O=C(/C=C/c1ccc(C(F)(F)F)cc1)Nc1ccc2c(c1)NCC(CO)C2>>CN1CC(CO)Cc2ccc(NC(=O)/C=C/c3ccc(C(F)(F)F)cc3)cc21,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20020035137A1,COC(=O)C(=Cc1ccc(N)c2ccccc12)NC(C)=O>>COC(=O)C(Cc1ccc(N)c2ccccc12)NC(C)=O,[Pd],CCOC(C)=O,CO,,,val
US05736487,CC(C)(O)c1nc2ccccc2s1.O=[N+]([O-])c1ccc(Cl)cc1>>CC(C)(Oc1ccc([N+](=O)[O-])cc1)c1nc2ccccc2s1,,CN(C)C=O,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20110098324A1,CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(Cc2ccccc2Cl)c1=O.NC1CC1>>O=C(O)CNC(=O)c1c(O)c(C(=O)NC2CC2)c(O)n(Cc2ccccc2Cl)c1=O,,ClC(Cl)Cl,,,,val
US05234925,Cc1ccc([N+](=O)[O-])c(C(N)=O)c1>>Cc1ccc(N)c(C(N)=O)c1,[Pd],CO,,[Br-].[K+],,val
US20090181965A1,COc1cc(NC(N)=S)ccc1-n1cnc(C)c1.O=C1C(Br)CCCC1c1ccccc1>>COc1cc(Nc2nc3c(s2)CCCC3c2ccccc2)ccc1-n1cnc(C)c1,,CCO,,,,val
US04469695,CC1CNCCN1.COc1cccccc1=O>>CC1CN(c2cccccc2=O)CCN1,,CO,,,,val
US20110098297A1,CC#CC(=O)OCC.COc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C(N)=S)[nH]c12>>CCOC(=O)CC1CN=C(c2cc3cc(Oc4ccc(S(C)(=O)=O)nc4)cc(OC)c3[nH]2)S1,,C1CCOC1,,CCCCP(CCCC)CCCC,,val
US20120295899A1,C=CCC1(C(C)C)CC(O)N(Cc2cc(C(F)(F)F)ccc2O[Si](C(C)C)(C(C)C)C(C)C)C1=O>>C=CCC1(C(C)C)CC2Oc3ccc(C(F)(F)F)cc3CN2C1=O,,C1CCOC1,CCOC(C)=O,O=C(O)C(F)(F)F,,val
US04622332,CCCCCCCCCCOC(=O)C(=Cc1cccc([N+](=O)[O-])c1)C(C)=O.CCOC(=O)CC(=N)N>>CCCCCCCCCCOC(=O)C1=C(C)NC(N)=C(C(=O)OCC)C1c1cccc([N+](=O)[O-])c1,,CCO,,Cl,[Na],val
US20060128685A1,COC(=O)[C@@H](N)COCCCl>>COC(=O)[C@@H]1COCCN1,,CO,,CCN(CC)CC,,val
US06265434B1,CC(C)(C)OC(=O)N1CCC(CCCc2ccccn2)CC1>>c1ccc(CCCC2CCNCC2)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04808597,C=C(C)CCOS(C)(=O)=O.Oc1ccccc1>>C=C(C)CCOc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150133428A1,CCOC(=O)CC1CCC(F)(F)CC1.CI>>CCOC(=O)C(C)C1CCC(F)(F)CC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US05093328,C=O.NC(=O)[C@@H]1C[C@@H](O)CN1>>CN1C[C@H](O)C[C@H]1C(N)=O,O=[Pt],CC(=O)O,O,[H][H],,val
US04647685,CCCCC/C=C\C/C=C\CCCCCCCC(COC(C)(C)C)OC>>CCCCC/C=C\C/C=C\CCCCCCCC(CO)OC,,CC(=O)OC(C)=O,,CCOCC,,val
US20080269208A1,CCOC(=O)C(C(=O)OCC)N1CCC[C@H]1CNC(=O)OCc1ccccc1>>CCOC(=O)C1C(=O)NC[C@@H]2CCCN12,[Pd],CCO,,,,val
US20090012074A1,C=CCN(C(=O)OC(C)(C)C)[C@H]1CCc2cc(N(C)S(=O)(=O)c3ccc(C(C)C)cc3)ccc2C1>>C=CCN[C@H]1CCc2cc(N(C)S(=O)(=O)c3ccc(C(C)C)cc3)ccc2C1,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,,val
US20100216810A1,CC(=O)Nc1nc2ccc(Oc3ccc(F)c(N)c3)c(C#N)c2s1.CC(C)(C#N)c1cccc(C(=O)O)c1>>CC(=O)Nc1nc2ccc(Oc3ccc(F)c(NC(=O)c4cccc(C(C)(C)C#N)c4)c3)c(C#N)c2s1,,C1CCOC1,CCOC(C)=O,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20070185155A1,BrCCCOc1ccc2ccccc2c1.OC(c1ccccc1)(c1ccccc1)C12CCN(CC1)CC2>>OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccc4ccccc4c3)(CC1)CC2.[Br-],,CC#N,,,,val
US20120077806A1,CCC[C@H](NC(=O)/C(C#N)=C/c1cccc(Br)n1)c1ccccc1.OCC(O)CS>>CCC[C@H](NC(=O)C(C#N)C(SCC(O)CO)c1cccc(Br)n1)c1ccccc1,,CC#N,,ClCCl,O,val
US20040116328A1,BrCc1ccccc1.OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)[C@H](O)[C@@H]1O>>O=c1[nH]cnc2ncn(Cc3ccccc3)c12,,CS(C)=O,,CCOC(C)=O,,val
US20030119842A1,CC(=O)Cl.Nc1cc(Cl)nc(N)n1.O=Cc1ccco1.[C-]#[N+]CC(=O)OC>>COC(=O)CNc1c(-c2ccco2)[n+](C(C)=O)c2nc(Cl)cc(N)n12.[Cl-],,[O-][Cl+3]([O-])([O-])O,,,,val
US20110288090A1,CC(C)(C)OC(=O)NCc1ccc(-c2nc3ccnc(C#CCO)c3cc2-c2ccccc2)cc1.[N-]=[N+]=[N-]>>CC(C)(C)OC(=O)NCc1ccc(-c2nc3ccnc(-c4[nH]nnc4CO)c3cc2-c2ccccc2)cc1,,CN(C)C=O,,O,,val
US20150299188A1,COC(OC)c1c(Cl)cnc(Br)c1N.Cc1nn(C)c(C)c1B1OC(C)(C)C(C)(C)O1>>COC(OC)c1c(Cl)cnc(-c2c(C)nn(C)c2C)c1N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20030105074A1,C#CC(C)(C)Cl.OC1CCNCC1>>C#CC(C)(C)N1CCC(O)CC1,[Cu],CCOCC,O,,,val
US20050070609A1,COC(=O)C1(CCCC=O)CCN(C(=O)OC(C)(C)C)CC1.O=[Cr](=O)=O>>COC(=O)C1(CCCC(=O)O)CCN(C(=O)OC(C)(C)C)CC1,,CC(C)=O,,O=S(=O)(O)O,,val
US20030166639A1,CCc1ccc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)c(C)cc3NC(=O)OC(C)(C)C)c2)cn1>>CCc1ccc(-c2cccc(C3=Nc4ccc(C(F)(F)F)cc4NC(=O)C3)c2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070004736A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)OCc1ncc2n1C(=O)N(C1CCNCC1)C2>>CC(C)(C)OC(=O)N1CCC(N2Cc3cnc(CO[Si](C)(C)C(C)(C)C)n3C2=O)CC1,,CCO,,,,val
US20160214997A1,CC(=O)NN.FC1(F)Oc2ccc3c(Cl)nc(Cl)nc3c2O1>>CC(=O)NNc1nc(Cl)nc2c3c(ccc12)OC(F)(F)O3,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20140128390A1,Cn1cc(-c2cc3c(N4CCC(NS(=O)(=O)c5ccc(OC(F)(F)F)cc5)CC4)ncnc3n2S(=O)(=O)c2ccccc2)cn1>>Cn1cc(-c2cc3c(N4CCC(NS(=O)(=O)c5ccc(OC(F)(F)F)cc5)CC4)ncnc3[nH]2)cn1,,O,,CO,[K+].[OH-],val
US20150133674A1,COC(CNS(=O)(=O)NC(=O)OC(C)(C)C)OC.Nc1nonc1-c1noc(=O)n1-c1ccc(F)c(Br)c1>>CC(C)(C)OC(=O)NS(=O)(=O)NCCNc1nonc1-c1noc(=O)n1-c1ccc(F)c(Br)c1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20070129341A1,C#CCBr.COC(=O)C(Cc1ccc(NC(=O)OC(C)(C)C)nc1)(C(=O)OC)c1c[nH]cn1>>C#CCn1cnc(C(Cc2ccc(NC(=O)OC(C)(C)C)nc2)(C(=O)OC)C(=O)OC)c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20120058988A1,COC(=O)c1cc(-c2ccc(OC)cc2)nc(-c2ccc(O)cc2)c1N=[N+]=[N-].COCCBr>>COCCOc1ccc(-c2nc(-c3ccc(OC)cc3)cc(C(=O)OC)c2N=[N+]=[N-])cc1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040266774A1,Cc1ncn(-c2cccc(N)c2)c1C.O=C(O)c1cccc2c1Cc1ccccc1-2>>Cc1ncn(-c2cccc(NC(=O)c3cccc4c3Cc3ccccc3-4)c2)c1C,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20050215797A1,Cc1c(C(F)(F)F)nn(C)c1O.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>Cc1c(C(F)(F)F)nn(C)c1OCC(F)(F)F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120288492A1,CCOC(=O)c1nc(-c2ccc(NC(=O)Oc3ccccc3)cc2)nc(N2CCOCC2)c1OCC.CN>>CCOC(=O)c1nc(-c2ccc(NC(=O)NC)cc2)nc(N2CCOCC2)c1OCC,,C1COCCO1,,,,val
US20060252931A1,CCOC(=O)c1cc(Cl)c(N)c(Br)c1>>Nc1c(Cl)cc(C(=O)O)cc1Br,,CCO,Cl,,,val
US20160122331A1,CC=CC(C)=O.C[Si](C)(C)OS(=O)(=O)C(F)(F)F>>C=C(/C=C/C)O[Si](C)(C)C,,ClCCl,,CCN(CC)CC,,val
US04079181,C1COCCN1.CC(OS(C)(=O)=O)=C(C(=O)OCC(Cl)(Cl)Cl)N1C(=O)C2N=C(COc3ccccc3)SC21>>CC(=C(C(=O)OCC(Cl)(Cl)Cl)N1C(=O)C2N=C(COc3ccccc3)SC21)N1CCOCC1,,c1ccccc1,,,,val
US20160228450A1,O=C(Br)C(=O)Br.O=C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)C(=O)C1>>O=C(OCc1ccccc1)N1CCC(N2CCC(Br)=CC2=O)CC1,,ClCCl,,CN(C)C=O,,val
US05859007,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1n[nH]c2ccccc12>>Cc1nn(C(=O)OC(C)(C)C)c2ccccc12,CN(C)c1ccncc1,CC#N,,CCN(CC)CC,,val
US20130022594A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1N>>COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1NC(=O)OC(C)(C)C,,Cc1ccccc1,,,,val
US20050288314A1,COCOCC(COc1cccc(F)c1C#N)c1ccc(Cl)cc1.N=C(N)N>>COCOCC(COc1cccc2nc(N)nc(N)c12)c1ccc(Cl)cc1,,CC(=O)N(C)C,,O=C(O)O,,val
US20090131458A1,CC1(C)CC(=CCCOCc2ccccc2)CCO1>>CC1(C)CC(CCCO)CCO1,[Pd],CCOC(C)=O,,,,val
US20080300232A1,CN(C(=O)CCl)C1CCN(Cc2ccccc2)CC1.Oc1cccc(Cl)c1>>CN(C(=O)COc1cccc(Cl)c1)C1CCN(Cc2ccccc2)CC1,,C1CCOC1,,O,CC(C)(C)[O-].[K+],val
US20060189601A1,COc1ccc2ncc(Cl)c(N3CCN(CCNC(=O)C(F)(F)F)CC3)c2c1>>COc1ccc2ncc(Cl)c(N3CCN(CCN)CC3)c2c1,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US04507498,CCCc1c(O)ccc(C(C)=O)c1O.CCCc1c(OCCCC(=O)OCC)ccc(C(C)=O)c1OCCCCOCCCCI>>CCCc1c(OCCCCOCCCCOc2c(C(C)=O)ccc(OCCCC(=O)OCC)c2CCC)ccc(C(C)=O)c1O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05556864,BrCC1CO1.CC(C)c1ccc(CCCCc2ccccc2O)cc1>>CC(C)c1ccc(CCCCc2ccccc2OCC2CO2)cc1,,CC(=O)N(C)C,,CC(C)(C)[O-].[K+],,val
US04933355,CC(C)Nc1nc(CO)cs1>>CC(C)Nc1nc(C=O)cs1,,CS(C)=O,,CCN(CC)CC,,val
US20140288040A1,CC[C@@H](N[S@](=O)C(C)(C)C)c1ccc(Cl)c(Oc2ccc(C=O)cc2)c1F.NO>>CC[C@@H](N[S@](=O)C(C)(C)C)c1ccc(Cl)c(Oc2ccc(C=NO)cc2)c1F,,O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20150258074A1,CI.ClC(c1ccccc1)(c1ccccc1)c1ccccc1.O=c1[nH][nH]c2cc(Cl)nc(Cl)c12>>COc1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c2cc(Cl)nc(Cl)c12,,CN(C)C=O,O,[H-].[Na+],O=C([O-])[O-].[K+].[K+],val
US20110136821A1,CC(C)(C)OC(=O)N1Cc2ccccc2C2(CCN(C(=O)/C=C/c3ccccc3C(F)(F)F)CC2)C1>>O=C(/C=C/c1ccccc1C(F)(F)F)N1CCC2(CC1)CNCc1ccccc12,,C1COCCO1,ClCCl,Cl,,val
US20160068559A1,CN(CCCN)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>CN(CCCNC(=O)Nc1ccc(Cl)c(C(F)(F)F)c1)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21,,ClCCl,,,,val
US20050107616A1,CC(C)(C)[C@H](O)c1nnc(-c2ccc(C(F)(F)F)cc2)o1.CCCC[C@H](N=C=O)C(=O)OC>>CCCC[C@H](NC(=O)O[C@H](c1nnc(-c2ccc(C(F)(F)F)cc2)o1)C(C)(C)C)C(=O)OC,,Cc1ccccc1,,,,val
US20110190246A1,CC(C)(O)C(=O)Nc1ccc2c(c1[N+](=O)[O-])CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12>>C[C@]12CC[C@@H]3c4ccc(N)c([N+](=O)[O-])c4CC[C@H]3[C@@H]1CCC2=O,,C1COCCO1,Cl,O,[Na],val
US20160122331A1,Br[Ga](Br)Br.C=CCCO.O=Cc1ccc2c(c1)OCO2>>BrC1CCOC(c2ccc3c(c2)OCO3)C1,,ClCCl,,,,val
US06245761B1,CN.Fc1ccc(Br)cc1COCC=CCBr>>CNC/C=C\COCc1cc(Br)ccc1F,,C1CCOC1,,,,val
US20040180878A1,COc1ccc(S(=O)(=O)Cl)c(OC)c1.O=C1Nc2ccc(Cl)cc2C1=O>>COc1ccc(S(=O)(=O)N2C(=O)C(=O)c3cc(Cl)ccc32)c(OC)c1,,CN(C)C=O,,[H-].[Na+],,val
US20150266878A1,Cc1n[nH]c2ccc(B3OC(C)(C)C(C)(C)O3)cc12.O=C(CO)NC[C@H](Nc1cncc(Br)c1)c1ccccc1>>Cc1n[nH]c2ccc(-c3cncc(N[C@@H](CNC(=O)CO)c4ccccc4)c3)cc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,N#N,O=C([O-])[O-].[K+].[K+],val
US20120142647A1,CCCNc1nc(NCCC)nc(N(C)OC(C)C)n1.O=S(=O)(O)O>>CCCNc1nc(NCCC)nc(N(C)OC(C)C)n1.O=S(=O)(O)O,,C1COCCO1,,,,val
US05998433,C=CCN(CCO)Cc1ccoc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>C=CCN(CCCl)Cc1ccoc1.Cc1ccc(S(=O)(=O)Cl)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20050192347A1,CC(C)(CCCN1C(=O)c2ccccc2C1=O)COC1CCCCO1>>CC(C)(CCCN)COC1CCCCO1,,CCO,ClCCl,NN,O,val
US20050277652A1,CNCCCN1CCN(C)CC1.Nc1cc(Oc2ccc([N+](=O)[O-])cc2F)ccn1.O=C(Cl)Oc1ccccc1>>CN1CCN(CCCN(C)C(=O)Nc2cc(Oc3ccc([N+](=O)[O-])cc3F)ccn2)CC1,,CN(C)C=O,,C1CCOC1,CCN(CC)CC,val
US05808112,CC(=O)O[C@@H]1CC[C@H](O)C1.CS(=O)(=O)Cl>>CC(=O)O[C@H]1CC[C@@H](OS(C)(=O)=O)C1,,COC(C)(C)C,,CCN(CC)CC,,val
US20020082260A1,II.OCC1CCCCCC1>>ICC1CCCCCC1,,ClCCl,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140057894A1,COC=Cc1c(-c2ccc(OC)cc2)nn2ccc(Br)cc12>>COc1ccc(-c2nn3ccc(Br)cc3c2CC=O)cc1,,C1CCOC1,,Cl,O,val
US20040224960A1,Nc1n[nH]c(CO)n1.O=CC(Cl)C=O>>OCc1nc2ncc(Cl)cn2n1,,CC(=O)O,,,,val
US20080070920A1,C=C(C)c1c(OCC[Si](C)(C)C)nc(OCC[Si](C)(C)C)nc1C(=O)c1cc(C)cc(C#N)c1>>C=C(C)c1c(C(=O)c2cc(C)cc(C#N)c2)[nH]c(=O)[nH]c1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04704462,C=CCc1cc2c(-c3cc(OC)c(OC)c(OC)c3)coc2cc1O>>CCCc1cc2c(cc1O)OCC2c1cc(OC)c(OC)c(OC)c1,[Pd],CC(=O)O,,,,val
US20070197537A1,COc1nccn(-c2ccc(F)cc2)c1=O.O=P(Cl)(Cl)Cl>>O=c1c(Cl)nccn1-c1ccc(F)cc1,,CN(C)C=O,,,,val
US20060241106A1,CCOC(=O)C(=O)CC(=O)c1cc(Br)c(OCc2ccccc2)cc1OCc1ccccc1.NO>>CCOC(=O)c1cc(-c2cc(Br)c(OCc3ccccc3)cc2OCc2ccccc2)on1,,CCO,,Cl,O,val
US20140154178A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1cc(CO[Si](C)(C)C(C)(C)C)ccc1NCc1ccc(NC(=O)OC(C)(C)C)cc1>>COc1cc(CO[Si](C)(C)C(C)(C)C)ccc1N(Cc1ccc(NC(=O)OC(C)(C)C)cc1)C(=O)OC(C)(C)C,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20060063779A1,Cc1nc(Cl)ccc1C(=O)Nc1ccc(Cl)c(-c2ccccn2)c1.NCCCn1ccnc1>>Cc1nc(NCCCn2ccnc2)ccc1C(=O)Nc1ccc(Cl)c(-c2ccccn2)c1,,CCCCO,,,,val
US20150291584A1,COC(=O)c1cccc2c1cnn2CC(C)C.O=C1CCC(=O)N1Cl>>COC(=O)c1cccc2c1c(Cl)nn2CC(C)C,,CC#N,,O,,val
US20120136014A1,Cc1cc(N)c(N)cc1C.N#Cc1ccc(C=O)cc1F>>Cc1cc2nc(-c3ccc(C#N)c(F)c3)[nH]c2cc1C,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20160002225A1,N#CCC(=O)N1CC[C@@H](Nc2n[nH]c3nccc(Oc4ccc(Oc5ccccc5)cc4)c23)C1.O=Cc1ccccn1>>N#C/C(=C\c1ccccn1)C(=O)N1CC[C@@H](Nc2n[nH]c3nccc(Oc4ccc(Oc5ccccc5)cc4)c23)C1,C1CCNCC1,CN(C)C=O,,,,val
US20110065736A1,COc1cc2c(Cl)ncnc2cc1OCC1CCN(C)CC1.Nc1c(F)cc(Br)cc1F>>COc1cc2c(Nc3c(F)cc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1,,CN(C)C=O,,[H-].[Na+],,val
US04694080,Cc1nnc(C2=C(O)c3ccccc3S(=O)(=O)N2C)o1.O=C(Cl)c1ccccc1>>Cc1nnc(C2=C(OC(=O)c3ccccc3)c3ccccc3S(=O)(=O)N2C)o1,,ClCCl,c1ccncc1,,,val
US20120088748A1,COC(=O)c1ccccc1OC[C@H]1CN(C(=O)OC(C)(C)C)CCO[C@H]1c1ccc(Cl)c(Cl)c1>>CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Cl)c(Cl)c2)[C@@H](COc2ccccc2C(=O)O)C1,,CO,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US04424213,CN=C=O.ON=C1SC2CCC1C2>>CNC(=O)ON=C1SC2CCC1C2,,ClCCl,,,,val
US20110136780A1,CC[C@@H](C)[C@@H](NCc1ccnc2c1c(C(=O)OC)cn2C(=O)OC(C)(C)C)C(=O)NC1CCCC1>>CC[C@@H](C)[C@@H](NCc1ccnc2[nH]cc(C(=O)O)c12)C(=O)NC1CCCC1,,CO,,[Na+].[OH-],,val
US20050222159A1,CC(C)n1nc(-c2nc(C#N)c(N=CN(C)C)nc2Cl)ccc1=O.OB(O)c1ccc(F)cc1>>CC(C)n1nc(-c2nc(C#N)c(N=CN(C)C)nc2-c2ccc(F)cc2)ccc1=O,,C1COCCO1,O,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20100317643A1,O=C(Cl)c1ccccc1.O=C(O)NC1CC(O)C1.c1ccncc1>>CC(C)(C)OC(=O)NC1CC(OC(=O)c2ccccc2)C1,,c1ccncc1,,,,val
US20080269200A1,NC(=O)c1cc(-c2ccccc2)cc2c(C3CCC(NCc4ccccc4)C3)c[nH]c12>>NC(=O)c1cc(-c2ccccc2)cc2c(C3CCC(N)C3)c[nH]c12,[Pd],CCO,,O=C[O-].[NH4+],,val
US20140275086A1,C=CS(=O)(=O)C=C.Cn1cnc(S(=O)(=O)N2C[C@H](N)[C@@H](c3ccc(F)cc3)C2)c1>>Cn1cnc(S(=O)(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N3CCS(=O)(=O)CC3)C2)c1,,C1CCOC1,,,,val
US20090298807A1,CCc1cc(C(=O)O)cs1.OCCc1cccc(CN2CCC3(CC2)CNCCO3)c1>>CCc1cc(C(=O)N2CCOC3(CCN(Cc4cccc(CCO)c4)CC3)C2)cs1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100168418A1,Cc1cc(=O)n(CCN2CCC(N(Cc3ccc4c(c3)OCCO4)C(=O)OC(C)(C)C)CC2)c2cc(-n3ccnc3)ccc12.Cl>>Cc1cc(=O)n(CCN2CCC(NCc3ccc4c(c3)OCCO4)CC2)c2cc(-n3ccnc3)ccc12.Cl,,CCOC(C)=O,,CO,,val
US20050245551A1,CCOC(OCC)OCC.CN1CCN(c2ccc(N)c(C(=O)Nc3cc(NC(=O)c4cc(F)cc(N5CCOCC5)c4)ccc3F)c2)CC1>>CN1CCN(c2ccc3ncn(-c4cc(NC(=O)c5cc(F)cc(N6CCOCC6)c5)ccc4F)c(=O)c3c2)CC1,,CCO,,CC(=O)O,,val
US20090105253A1,NCCN1CCCCC1.[N-]=[N+]=Nc1ccc(C(=O)O)cc1>>[N-]=[N+]=Nc1ccc(C(=O)NCCN2CCCCC2)cc1,,CC#N,CN(C)C=O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20110071197A1,CC(C)(C)OC(=O)Nc1cccc(O)c1.COC(=O)c1cc(F)ccc1[N+](=O)[O-]>>COC(=O)c1cc(Oc2cccc(NC(=O)OC(C)(C)C)c2)ccc1[N+](=O)[O-],,CN(C)C=O,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20090111811A1,CC(C)(C)OC(=O)NN.COC(=O)c1ccc(C(=O)O)cc1>>COC(=O)c1ccc(C(=O)NNC(=O)OC(C)(C)C)cc1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCN=C=NCCCN(C)C,,val
US05391566,BrC(Br)(Br)Br.CCCc1cc(CO)cc(Cl)c1OC(C(=O)OC)c1ccc2c(c1)OCO2>>CCCc1cc(CBr)cc(Cl)c1OC(C(=O)OC)c1ccc2c(c1)OCO2,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US03957782,CCI.CCn1ncc2nc(C(=O)O)c(C)nc21>>CCOC(=O)c1nc2cnn(CC)c2nc1C,,CCO,,[Na],,val
US20160039811A1,CC#N.COC(=O)C(C)(C)COCc1ccc(OC)cc1>>COc1ccc(COCC(C)(C)C(=O)CC#N)cc1,,C1CCOC1,,[H-].[Na+],,val
US20050215572A1,CN(C)CCN.CS(=O)(=O)c1nc2c(c(Nc3ccc(C(F)(F)F)cc3)n1)CCN(c1ncccc1Cl)C2>>CN(C)CCNc1nc2c(c(Nc3ccc(C(F)(F)F)cc3)n1)CCN(c1ncccc1Cl)C2,,CS(C)=O,,O,,val
US20090156642A1,Cl.Nc1cccc(F)c1F.O=N[O-]>>Cl.NNc1cccc(F)c1F,,Cl,O,Cl[Sn]Cl,,val
US20100056507A1,CC(C)(C)c1cc(-c2nnc(CCc3ccc(N)cc3)s2)cc(C(C)(C)C)c1.CCCN=C=O>>CCCNC(=O)Nc1ccc(CCc2nnc(-c3cc(C(C)(C)C)cc(C(C)(C)C)c3)s2)cc1,,C1CCOC1,,,,val
US20080293712A1,COC(=O)c1cncc(Oc2cc(NC(=O)OC(C)(C)C)c[n+]([O-])c2)c1>>COC(=O)c1cncc(Oc2cncc(NC(=O)OC(C)(C)C)c2)c1,[Pd],CO,,O=C[O-].[NH4+],,val
US20020107422A1,CC(=CCBr)CBr.O=C([O-])c1ccccc1>>CC(=CCOC(=O)c1ccccc1)CBr,,CN(C)C=O,,O,,val
US20040010007A1,CCc1nc2c(c(C)c(C)n3nnnc23)n1CCOCCNC(=O)OC(C)(C)C>>CCc1nc2c(c(C)c(C)n3nnnc23)n1CCOCCN,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100137313A1,COc1cc(C)cc(Nc2ncc(-c3cc(C(=O)O)c(=O)n(C)c3)c(-n3nc(C(F)(F)F)cc3C)n2)c1.CS(N)(=O)=O>>COc1cc(C)cc(Nc2ncc(-c3cc(C(=O)NS(C)(=O)=O)c(=O)n(C)c3)c(-n3nc(C(F)(F)F)cc3C)n2)c1,CN(C)c1ccncc1,ClCCl,ClCCl,CCN(CC)CC,C[n+]1ccccc1Cl.[I-],val
US20110053929A1,CC(=O)c1sc(S(C)(=O)=O)nc1N.CC(C)(C)OC(=O)N1CCCC(N)C1>>CC(=O)c1sc(NC2CCCN(C(=O)OC(C)(C)C)C2)nc1N,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US08642788B2,COc1cccc2cc(C(=O)O)c(=O)oc12.Nc1cccc(-c2ccccc2S(=O)(=O)N2CCOCC2)c1>>COc1cccc2cc(C(=O)Nc3cccc(-c4ccccc4S(=O)(=O)N4CCOCC4)c3)c(=O)oc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120040949A1,CC(C)(CO)c1cc(F)c2c(=O)[nH]ccc2c1.CCN(CC)S(F)(F)F>>CC(C)(CF)c1cc(F)c2c(=O)[nH]ccc2c1,,ClCCl,,O,,val
US20140051677A1,CC(C)(C)OC(=O)N1CC[C@H](OS(C)(=O)=O)C1.CC1(C)OB(c2ccc(O)cc2)OC1(C)C>>CC(C)(C)OC(=O)N1CC[C@@H](Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04496560,CC(C)(C)OC(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(c3cnc(NC(=O)c4ccccc4)s3)CSC12>>NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(c3cnc(NC(=O)c4ccccc4)s3)CSC12,,CC#N,,CS(=O)(=O)O,,val
US20090111859A1,CCC[C@H](CC(=O)OC)c1ccc(OCc2ccc(C(C)(C)C)c(-c3cc(OC)ccc3F)c2)c(C)c1>>CCC[C@H](CC(=O)O)c1ccc(OCc2ccc(C(C)(C)C)c(-c3cc(OC)ccc3F)c2)c(C)c1,,C1CCOC1,CO,[Li+].[OH-],,val
US20100331293A1,CC(C)c1c(-c2ccccn2)nc2cc(F)ccc2c1Cl.Nc1cc(N2CCOCC2)cnc1N1CCOCC1>>CC(C)c1c(-c2ccccn2)nc2cc(F)ccc2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1,,Cc1ccccc1,,,,val
US06589950B1,CCN.Clc1nc(Cl)c2[nH]cnc2n1>>CCNc1nc(Cl)nc2nc[nH]c12,,CCCCO,,,,val
US20140249139A1,CC(=O)N1CCNCC1.O=C(O)c1cncc(-c2ncnc3ccc(Br)cc23)c1>>CC(=O)N1CCN(C(=O)c2cncc(-c3ncnc4ccc(Br)cc34)c2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06326386B1,CC(C)(C)OC(=O)N(CCOc1cc(Cl)cc(C(=O)O)c1)c1ccncc1.CC1CCCCN1>>CC1CCCCN1C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US04029801,O=C(CCCN1CCC(NC(=O)c2ccccc2)CC1)c1ccccc1>>NC1CCN(CCCC(=O)c2ccccc2)CC1,,Cl,,,,val
US20050043309A1,COC(=O)C(C)(C)COS(C)(=O)=O.Oc1ccccc1Br>>COC(=O)C(C)(C)COc1ccccc1Br,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05070089,CSC(=S)N1CCN(Cc2cc(OC(C)=O)ccc2O)CC1.Cl>>CSC(=S)N1CCN(Cc2cc(O)ccc2O)CC1.Cl,,CCO,,,,val
US20080119518A1,Brc1cccc(Br)n1.COc1cccc(O)c1C=O>>COc1cccc(Oc2cccc(Br)n2)c1C=O,,CN1CCCC1=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20160184318A1,Cc1nn[nH]n1.N#Cc1ccc(Br)c(CBr)c1>>Cc1nnn(Cc2cc(C#N)ccc2Br)n1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20120010190A1,CON(C)C(=O)CC(c1ccc(Br)cc1)c1ccccc1C.COc1ccc(Br)cc1>>COc1ccc(C(=O)CC(c2ccc(Br)cc2)c2ccccc2C)cc1,,C1CCOC1,O,[Li]CCCC,[Cl-].[NH4+],val
US04788204,CC(Cc1nc(-c2ccccc2)nc2ccccc12)C(=O)O.CNC(C)C>>CC(Cc1nc(-c2ccccc2)nc2ccccc12)C(=O)N(C)C(C)C,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20110021454A1,C#C[C@]1(COC(c2ccccc2)(c2ccccc2)c2cccc(OC)c2OC)O[C@@H](n2cc(C)c(=O)[nH]c2=O)C[C@@H]1N=[N+]=[N-].O=C(O)C(F)(F)F>>C#C[C@]1(CO)O[C@@H](n2cc(C)c(=O)[nH]c2=O)C[C@@H]1F,,ClCCl,,[NH4+].[OH-],,val
US20110160180A1,CCN(CC(=O)O)C(=O)c1ccc2c(c1)c1c(n2C)CCC(C2CCOCC2)C1.COCCN>>CCN(CC(=O)NCCOC)C(=O)c1ccc2c(c1)c1c(n2C)CCC(C2CCOCC2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090131436A1,COc1cc2c(cc1[N+](=O)[O-])N(C)C(=O)CO2>>COc1cc2c(cc1N)N(C)C(=O)CO2,,CCOC(C)=O,,[Na+].[OH-],,val
US20150361096A1,Brc1scnc1OCC1CO1.CC(C)[Si](Cl)(C(C)C)C(C)C>>CC(C)[Si](c1nc2c(s1)C(CO)CO2)(C(C)C)C(C)C,,C1CCOC1,,[Li]CCCC,,val
US20150152046A1,CC(C)(C)NC(=O)c1ccc(N)cc1.CCOC(=O)[C@@H]1CSC2=C(Cl)CC(C)(C)CC2=N1>>CCOC(=O)C1CSC2=C(CC(C)(C)C/C2=N\c2ccc(C(=O)NC(C)(C)C)cc2)N1,,CCO,,,,val
US20140051679A1,COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1OC1CCN(C=O)CC1.O=C(NC(c1ccccn1)C1CC1)c1ccc2[nH]nc(I)c2c1>>COc1cc(-c2n[nH]c3ccc(C(=O)NC(c4ccccn4)C4CC4)cc23)ccc1OC1CCN(C=O)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20120225867A1,CC1(C)OB(c2ccnn2C2CCCCO2)OC1(C)C.Clc1ccc(Br)cc1Cl>>Clc1ccc(-c2ccnn2C2CCCCO2)cc1Cl,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US04000153,C=O.Cc1nncn1-c1ccccc1C(=O)c1ccccc1Cl>>Cc1nnc(CO)n1-c1ccccc1C(=O)c1ccccc1Cl,,Cc1ccccc1C,,,,val
US20150283114A1,C#CC(C)(C)Oc1ccc(Br)cc1C=O>>CC1(C)C=Cc2cc(Br)cc(C=O)c2O1,,CC#N,,,,val
US20110028450A1,COc1cc2c(cc1Br)-c1c(Br)c3c(n1CC2)C(=O)N(C(C)(C)C)CCCC3.OB(O)c1cccnc1>>COc1cc2c(cc1-c1cccnc1)-c1c(Br)c3c(n1CC2)C(=O)N(C(C)(C)C)CCCC3,,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20060025433A1,COC(=O)c1cccc(CNC2CCC(CNc3nc(NCc4ccccc4OC(F)(F)F)ncc3[N+](=O)[O-])CC2)c1>>O=C(O)c1cccc(CN[C@@H]2CC[C@@H](CNc3nc(NCc4ccccc4OC(F)(F)F)ncc3[N+](=O)[O-])CC2)c1,O,CO,,[Li+].[OH-],,val
US20080287396A1,CCOP(=O)(OCC)C(CC(=O)N1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2OC)CC1C)P(=O)(OCC)OCC>>COc1c(N2CCN(C(=O)CC(P(=O)(O)O)P(=O)(O)O)C(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,,ClCCl,,C[Si](C)(C)Br,,val
US20030195221A1,C[C@H](Nc1cc(-c2nc(N3C[C@H]4CC3CN4C(=O)OC(C)(C)C)n3cnnc3c2-c2cccc(C(F)(F)F)c2)ccn1)c1ccccc1>>C[C@H](Nc1cc(-c2nc(N3CC4CC3CN4)n3cnnc3c2-c2cccc(C(F)(F)F)c2)ccn1)c1ccccc1,,CCOC(C)=O,,,,val
US20120122947A1,CC(=O)OC1CCC(NC(=O)[C@H]2[C@H](c3cccc(Cl)c3F)[C@]3(C(=O)N(C(C)=O)c4cc(Cl)ccc43)[C@H](CC(C)(C)C)N2C(C)=O)CC1>>CC(=O)N1[C@@H](C(=O)N[C@@H]2CC[C@@H](O)CC2)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)[C@@H]1CC(C)(C)C,,CO,,O=C([O-])[O-].[K+].[K+],,val
US05011825,CC(C)(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OCC1c2ccccc2-c2ccccc21>>O=C(NCCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)OCc1ccccc1,,O=C(O)C(F)(F)F,,,,val
US06846827B1,C=CCNc1nccc(Nc2cc(NC(=O)c3ccnc(N4CCOCC4)c3)ccc2C)n1>>Cc1ccc(NC(=O)c2ccnc(N3CCOCC3)c2)cc1Nc1ccnc(N)n1,[Pd],CC(=O)N(C)C,,CS(=O)(=O)O,,val
US20140288090A1,COC(=O)[C@@H](C)O.Oc1cccc(CBr)c1>>COC(=O)[C@H](C)Oc1cccc(CBr)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120149691A1,CN[C@H]1CN(Cc2ccccc2)CC[C@H]1C.N#Cc1cnn2cccc2c1Cl>>C[C@@H]1CCN(Cc2ccccc2)C[C@@H]1N(C)c1c(C#N)cnn2cccc12,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20080015203A1,C[C@@H](CO[Si](C)(C)C(C)(C)C)Oc1cc(OCc2ccccc2)cc(C(=O)O)c1.Cc1cnc(N)s1>>Cc1cnc(NC(=O)c2cc(OCc3ccccc3)cc(O[C@@H](C)CO[Si](C)(C)C(C)(C)C)c2)s1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04414221,NC(=NO)c1ccccc1Cl.O=C(Cl)c1ccccc1Cl>>Clc1ccccc1-c1noc(-c2ccccc2Cl)n1,,C1COCCO1,ClCCl,CCOCC,FB(F)F,val
US04151179,CCc1oc2ccc(C(C)C(=O)OC)cc2c(=O)c1C>>CCc1oc2ccc(C(C)C(=O)O)cc2c(=O)c1C,,CCO,O,O=C([O-])O.[Na+],,val
US06028032,CC1=C(c2ccccc2)C(=O)N(C(C)(C)C(=O)Nc2cccc(Cl)c2)CO1.O=C1CCC(=O)N1Br>>CC(C)(C(=O)Nc1cccc(Cl)c1)N1COC(CBr)=C(c2ccccc2)C1=O,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US05229379,CCOC(OCC)P(=O)(CCCNCc1ccc(Cl)cc1)OCC>>CCOC(OCC)P(=O)(O)CCCNCc1ccc(Cl)cc1,,CCO,O,[Li+].[OH-],,val
US20040138249A1,CCOC(=O)c1c(-c2cc(C)c(O)c(C)c2)c(C)n2c1-c1cc(OC)c(OC)cc1CC2>>CCOC(=O)c1c(-c2cc(C)c(O)c(C)c2)c(C)n2c1-c1cc(O)c(OC)cc1CC2,,CCOC(C)=O,Cl,c1ccncc1,,val
US20160096827A1,N#Cc1ccc(F)c(C#N)c1.OC1CCOCC1>>N#Cc1ccc(OC2CCOCC2)c(C#N)c1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US05428044,CC(=O)Cl.CN(c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)c1ccn(-c2ccccc2)n1>>CC(=O)Oc1c(C(C)(C)C)cc(N(C)c2ccn(-c3ccccc3)n2)cc1C(C)(C)C,,C1CCOC1,,O,[Li]CCCC,val
US20060270706A1,COC(=O)Cn1cc(/C=C2\CN(C(c3ccccc3)(c3ccccc3)c3ccccc3)CCC2=O)nn1>>COC(=O)Cn1cc(/C=C2\CN(C(c3ccccc3)(c3ccccc3)c3ccccc3)CCC2O)nn1,,C1CCOC1,,[BH4-].[Na+],,val
US20070225267A1,CC(=O)N[C@@H](Cc1cc(O)cc(F)c1)[C@H](O)[C@H]1CO[C@@H](OCC(C)(C)C)[C@H](C)N1C(=O)OC(C)(C)C.CC(C)CBr>>CC(=O)N[C@@H](Cc1cc(F)cc(OCC(C)C)c1)[C@H](O)[C@H]1CO[C@@H](OCC(C)(C)C)[C@H](C)N1C(=O)OC(C)(C)C,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030055085A1,Cc1cncc(Cl)c1-c1nc(-c2ccccn2)no1.c1cncc(B2OCCCO2)c1>>Cc1cncc(-c2cccnc2)c1-c1nc(-c2ccccn2)no1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20120157459A1,Fc1ccc(C(F)(F)F)cc1Cl.OB(O)c1ccc(O)cc1>>OB(O)c1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US08378092B2,C1CN(C2CC2)CCN1.Cc1c(-c2cccnc2)cccc1S(=O)(=O)N[C@@H](CNC(=O)c1ccc(Cl)s1)C(=O)O.ClCCl>>Cc1c(-c2cccnc2)cccc1S(=O)(=O)N[C@@H](CNC(=O)c1ccc(Cl)s1)C(=O)N1CCN(C2CC2)CC1.Cl.Cl,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20070240609A1,CC(C)(O)C(=O)c1ccc(CO)cc1.COC(=O)Cl>>COC(=O)OCc1ccc(C(=O)C(C)(C)O)cc1,,C1CCOC1,,O,c1ccncc1,val
US20150051410A1,CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](OC2CCCCO2)[C@@H]1/C=C/[C@H](CCc1ccccc1)OC1CCCCO1>>CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCc1ccccc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20100069352A1,COc1cc(N2CCc3nc(-c4ccc(Cl)cc4)sc3C2=O)ccc1OC1CNC1.ClCCCl.OC1COC(O)CO1>>COc1cc(N2CCc3nc(-c4ccc(Cl)cc4)sc3C2=O)ccc1OC1CN(CCO)C1.Cl,,ClCCCl,,[Na+].[OH-],,val
US20090048238A1,C1CCN(C2CCNCC2)C1.Cc1c(Br)cccc1C(=O)O>>Cc1c(Br)cccc1C(=O)N1CCC(N2CCCC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030069246A1,COC(=O)CC(C)=O.COc1cc(Cl)c(-c2c(C)n[nH]c2N)c(Cl)c1>>COc1cc(Cl)c(-c2c(C)nn3c(=O)cc[nH]c23)c(Cl)c1,,CC(=O)O,CCOCC,,,val
US20070066624A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCC(N)CO>>CCCCC(CO)NC(=O)OC(C)(C)C,,ClCCl,,CC(C)NC(C)C,,val
US20080234260A1,COC(=O)CN1CCC(C(F)(F)F)CC1>>OCCN1CCC(C(F)(F)F)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070275907A1,CC(=O)[O-].CCc1ccc(Cc2cc3c(cc2Cl)CO[C@]32O[C@H](COS(=O)(=O)c3ccc(C)cc3)[C@@H](O)[C@H](O)[C@H]2O)cc1>>CCc1ccc(Cc2cc3c(cc2Cl)CO[C@]32O[C@H](COC(C)=O)[C@@H](O)[C@H](O)[C@H]2O)cc1,,CN(C)C=O,,O,,val
US20020090728A1,CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)O.Fc1nc(F)nc(F)n1>>CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)F,,ClCCl,,c1ccncc1,,val
US20120258952A1,CC(C)(C)OC(=O)N1CCNCC1.CCc1nn(Cc2cccc(C=O)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12>>CCc1nn(Cc2cccc(CN3CCN(C(=O)OC(C)(C)C)CC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12,,CO,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20060040965A1,CC[Si](CC)(CC)c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1.O=C1CCC(=O)N1I>>Ic1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1,,CN(C)C=O,,,,val
US20090247534A1,CCOC(=O)CC1CCC(c2ccccc2)CC1.O=C(Br)CBr>>CCOC(=O)CC1CCC(c2ccc(C(=O)CBr)cc2)CC1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04259510,N.O=C(Cl)c1cccc(F)c1>>NC(=O)c1cccc(F)c1,,c1ccccc1,,,,val
US04369139,COc1ccc(C(=O)Cl)cc1.NCCCC(=O)O>>COc1ccc(C(=O)NCCCC(=O)O)cc1,,O,,Cl,[Na+].[OH-],val
US06143764,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.O=C(O)C12CC3CC(CC(C3)C1)C2>>COc1cc2nccc(Oc3ccc(NC(=O)C45CC6CC(CC(C6)C4)C5)cc3)c2cc1OC,,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20020137961A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O.CC(C)(C)[Si](C)(C)Oc1ccc([C@@H]2CC[C@@H](O)CC2)c(O[Si](C)(C)C(C)(C)C)c1>>CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)O[C@@H]1CC[C@@H](c2ccc(O[Si](C)(C)C(C)(C)C)cc2O[Si](C)(C)C(C)(C)C)CC1,,ClCCl,,CC(C)N=C=NC(C)C,,val
US20050070580A1,CC(=O)NCC(CCl)OC(C)=O.O=C1C=CN(c2ccc(NC(=O)OCc3ccccc3)cc2)CC1>>CC(=O)NCC1CN(c2ccc(N3C=CC(=O)CC3)cc2)C(=O)O1,,CN(C)C=O,CO,C1CCOC1,,val
US20090247507A1,Cn1cnc(CN2CCN(C(=O)OC(C)(C)C)CC2)c1.Nc1ncc(Br)c(Cl)c1[N+](=O)[O-]>>Cn1cnc(CN2CCN(c3c(Br)cnc(N)c3[N+](=O)[O-])CC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090258885A1,CC(C)(C)C(c1ccccc1)c1cc(OCc2ccc3cc(F)ccc3n2)ccc1C(=O)CBr.[N-]=[N+]=[N-]>>CC(C)(C)C(c1ccccc1)c1cc(OCc2ccc3cc(F)ccc3n2)ccc1C(=O)CN=[N+]=[N-],,CN(C)C=O,,O,,val
US20050004207A1,CC(C)(C)[Si](C)(C)Cl.O=C1c2ccccc2C(=O)N1Cc1cccc(CO)c1>>CC(C)(C)[Si](C)(C)OCc1cccc(CN2C(=O)c3ccccc3C2=O)c1,,C1CCOC1,ClCCl,O,c1c[nH]cn1,val
US20140073658A1,N#Cc1ncc(Br)cc1[N+](=O)[O-].Oc1ccc(F)c(F)c1.Sc1ccccn1>>N#Cc1ncc(Sc2ccccn2)cc1Oc1ccc(F)c(F)c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],[Cl-].[NH4+],val
US20030171411A1,CCCCC(Oc1ccc(OC)cc1)C(=O)O.Nc1ccccn1>>CCCCC(Oc1ccc(OC)cc1)C(=O)Nc1ccccn1,,C1CCOC1,,,,val
US20070232645A1,CC(=O)Nc1ccc(O)cc1.O=[N+]([O-])c1cc(Cl)cc([N+](=O)[O-])c1>>CC(=O)Nc1ccc(Oc2cc(Cl)cc([N+](=O)[O-])c2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US05854179,CCSc1ccc(NC=O)cc1S(=O)(=O)NC(C)(C)C>>CCSc1ccc(NC=O)cc1S(N)(=O)=O,,O=C(O)C(F)(F)F,,,,val
US20090181942A1,COC(=O)C[C@H]1S[C@H](c2cccc(OC)c2OC)c2cc(Cl)ccc2-n2c1nnc2C(F)(F)F>>COc1cccc(C2SC(CC(=O)O)c3nnc(C(F)(F)F)n3-c3ccc(Cl)cc32)c1OC,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US06413974B1,Clc1nc(Cl)c2ncn(C3CCCC3)c2n1.NCC1CCCCO1>>Clc1nc(NCC2CCCCO2)c2ncn(C3CCCC3)c2n1,,CCN(CC)CC,,,,val
US20160016966A1,Cn1cc(Br)c2oc(C=O)cc2c1=O.O=S1(=O)CCNCC1>>Cn1cc(Br)c2oc(CN3CCS(=O)(=O)CC3)cc2c1=O,,CO,,[BH3-]C#N.[Na+],,val
US20150011773A1,CC(C)(C)OC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C.CC(C)(C)Oc1cc(CBr)ccc1OCCOCc1ccccc1>>CC(C)(C)OC(=O)N[C@@H](C[C@H](Cc1ccc(OCCOCc2ccccc2)c(OC(C)(C)C)c1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,,C1CCOC1,,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20050004162A1,CCOC(=O)Cc1coc2c(OC)cccc12>>COc1cccc2c(CCO)coc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110152290A1,Cc1cccc(C2(C#N)CC2)c1>>Cc1cccc(CC#N)c1,,CCOC(C)=O,,,,val
US05358950,CCCC(=O)C(Cc1ccc(-c2ccccc2C#N)cc1)C(=O)OCC.NC(N)=S>>CCCc1nc(S)nc(O)c1Cc1ccc(-c2ccccc2C#N)cc1,,CO,,[Na],,val
US20110201593A1,CC(C)NC(=O)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1>>CC(C)NC(=O)[C@@H]1CC[C@@H](N)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05498609,CN1CCNCC1.O=C(O)COc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCCc3cc(Cl)ccc32)cn1>>CON(C(=O)C1=CC=CC(=C=O)C1N1CCN(C)CC1)c1ccc(C(=O)N2CCCCc3cc(Cl)ccc32)cn1,,ClCCl,O,CCN(CC)CC,O=C1OCCN1P(=O)(Cl)N1CCOC1=O,val
US04052455,N=C(N)c1ccc(N)cc1>>N=C(N)c1ccc(N)cc1,,O,,Cl,[Na+].[OH-],val
US05668157,NCCF.O=[N+]([O-])c1ccc(Cl)nc1>>O=[N+]([O-])c1ccc(NCCF)nc1,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20040152742A1,CCN(CC)CCc1ccc([N+](=O)[O-])cc1Cl>>CCN(CC)CCc1ccc(N)cc1Cl,[Ni],C1CCOC1,,[H][H],,val
US06110933,CC(C)CCCCCCCCCCCBr.O=C=O>>CC(C)CCCCCCCCCCCC(=O)O,,C1CCOC1,CCOC(C)=O,Cl,[Mg],val
US20100120785A1,Cc1c(C=O)cnn1-c1ccccc1.Clc1nccnc1N1CCNCC1>>Cc1nn(-c2ccccc2)cc1CN1CCN(c2nccnc2Cl)CC1,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US06806230B1,CC(C)C(O)c1cncnc1C(F)(F)F.O=S(Cl)Cl>>CC(C)C(Cl)c1cncnc1C(F)(F)F,,ClC(Cl)Cl,,,,val
US20070299112A1,NC(=O)c1cc2ccsc2[nH]1.c1ccc(SSc2ccccn2)nc1>>NC(=O)c1[nH]c2sccc2c1Sc1ccccn1,,CN(C)C=O,O,[H-].[Na+],,val
US20100222379A1,NCc1ccc(C(=O)Nc2ccccc2N)cc1.O=C(O)C(=Cc1ccc(F)c(F)c1)c1ccc(F)cc1>>Nc1ccccc1NC(=O)c1ccc(CNC(=O)C(=Cc2ccc(F)c(F)c2)c2ccc(F)cc2)cc1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US04405810,Cc1ccc(S(=O)(=O)NN)cc1.O=C1CCCC(=O)C1Cc1ccccc1>>Cc1ccc(S(=O)(=O)NN=C2CCCC(=O)C2Cc2ccccc2)cc1,,CO,,Cl,,val
US20150011530A1,CC(C)(C)OC(=O)N1CC2(CCC(O)CC2)C1.Nc1ncnc2[nH]nc(-c3ccc(Oc4ccccc4)cc3)c12>>CC(C)(C)OC(=O)N1CC2(CCC(n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)C1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04618677,Cl.Cl.ClCCCN1CCN(CCCc2ccccc2)CC1.NC(N)=S>>Cl.Cl.SCCCN1CCN(CCCc2ccccc2)CC1,,CCO,O,CCN(CC)CC,[Na+].[OH-],val
US20050148624A1,CCC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(C#N)cc1.C[Sn](C)(C)N=[N+]=[N-]>>CCC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(-c2nnn[nH]2)cc1,,Cc1ccccc1,,CO,O,val
US20070054909A1,CC(C)(C)OC(=O)N1CC(F)(F)CC1CO>>CC(C)(C)OC(=O)N1CC(F)(F)CC1C=O,,ClCCl,,CCN(CC)CC,CS(C)=O,val
US07763657B2,ClI.N#Cc1ccc(N)c(C(F)(F)F)c1>>N#Cc1cc(I)c(N)c(C(F)(F)F)c1,,ClCCl,,,,val
US05444080,CCCCc1ncc(C(Cc2ccccc2)(C(=O)OCC)C(=O)OCC)n1Cc1ccccc1Cl>>O=C(O)C(Cc1ccccc1)C(=O)O,,CCO,O,[K+].[OH-],,val
US20050261310A1,CC1CN(C2(C)CCN(C(=O)OC(C)(C)C)CC2)CCN1C1CC(O)c2cc(C(F)(F)F)ccc21.CI>>COC1CC(N2CCN(C3(C)CCN(C(=O)OC(C)(C)C)CC3)C[C@@H]2C)c2ccc(C(F)(F)F)cc21,,C1CCOC1,,[H-].[Na+],,val
US20050085508A1,CCOC(=O)CP(=O)(OCC)OCC.O=C1CCCCCCC1>>CCOC(=O)C=C1CCCCCCC1,,C1CCOC1,O,Cl,[H-].[Na+],val
US20100029653A1,CCOC(=O)c1nc(Cc2ccccc2F)c(N)[nH]1.COC(CC(OC)OC)OC>>CCOC(=O)c1nc(Cc2ccccc2F)c2ncccn12,,CCO,CO,,,val
US20080214849A1,CC(=O)OC(C)=O.OCCCCCCBr>>CC(=O)OCCCCCCBr,CN(C)c1ccncc1,C1CCOC1,,CC(C)OC(C)C,,val
US20150133402A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=Cc1cccc(OCCCOCc2ccccc2)c1Br>>CC1(C)OB(c2c(C=O)cccc2OCCCOCc2ccccc2)OC1(C)C,,CN(C)C=O,,CC(=O)[O-].[K+],,val
US20150051416A1,CCOC(=O)C1=C(N)CCCC1.ClCc1ccccc1.O>>CCOC(=O)C1=C(NC(=O)c2ccccc2)CCCC1,,CC#N,,c1ccncc1,,val
US20080064676A1,CC1(C)COC(CSCC(=O)O)(c2ccccc2)OC1.O=C1N[C@@H](c2ccccc2)CO1>>CC1(C)COC(CSCC(=O)N2C(=O)OC[C@@H]2c2ccccc2)(c2ccccc2)OC1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05547972,C=O.CC(C)(NCCCn1ccnc1)c1ccc(Cl)cc1>>CN(CCCn1ccnc1)C(C)(C)c1ccc(Cl)cc1,,O=CO,,,,val
US04006145,Cl.OC1Cc2cc(Br)ccc2Sc2ccccc21>>ClC1Cc2cc(Br)ccc2Sc2ccccc21,,c1ccccc1,,[Ca+2].[Cl-].[Cl-],,val
US05914328,NN.O=[N+]([O-])c1cnc(Cl)c([N+](=O)[O-])c1>>NNc1ncc([N+](=O)[O-])cc1[N+](=O)[O-],,CO,,N,,val
US20030232825A1,CC(C)(C)OC(=O)N1CCN(c2cccc3c2OCCN3)CC1.CS(=O)(=O)c1cccc(S(=O)(=O)Cl)c1.Cl.O=C(O)C(F)(F)F>>CN1CCN(c2cc(Cl)cc3c2OCCN3S(=O)(=O)c2ccccc2F)CC1.Cl,,CCO,,,,val
US20140088079A1,CC1(C)OB(c2ccc3c(c2)CCC3)OC1(C)C.Clc1ccc([C@@H]2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)cc1CBr>>Clc1ccc([C@@H]2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)cc1Cc1ccc2c(c1)CCC2,,CCO,Cc1ccccc1,O=C([O-])[O-].[Cs+].[Cs+],,val
US05191092,CCOC(=O)CBr.O=C1CCCc2c(O)cc3c(c21)CCCC3>>CCOC(=O)COc1cc2c(c3c1CCCC3=O)CCCC2,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06350749B1,Cc1csc2c1C(=O)CC(c1ccccc1Cl)C2.Cl.N=C(N)NN>>Cc1csc2c1C(=NNC(=N)N)CC(c1ccccc1Cl)C2.Cl,,CCO,,Cl,O,val
US20090054425A1,C=Cc1cn(S(=O)(=O)c2ccc(C)cc2)c2nc(Cl)nc(Nc3ccc4cn[nH]c4c3)c12>>CCc1cn(S(=O)(=O)c2ccc(C)cc2)c2nc(Cl)nc(Nc3ccc4cn[nH]c4c3)c12,[Pd],CCOC(C)=O,,,,val
US20090275570A1,CN(c1ncc(C(N)=O)c2sc(Br)cc12)[C@H]1CCCN(C(=O)OC(C)(C)C)C1.OB(O)c1ccccc1OCc1ccccc1>>CN(c1ncc(C(N)=O)c2sc(-c3ccccc3OCc3ccccc3)cc12)[C@H]1CCCN(C(=O)OC(C)(C)C)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050090490A1,Cn1c(Cl)nc(-c2ccncc2)cc1=O.O=C(Nc1ccccc1)C1CCCNC1>>Cn1c(N2CCCC(C(=O)Nc3ccccc3)C2)nc(-c2ccncc2)cc1=O,,C1CCOC1,,CCN(CC)CC,Cl,val
US20120071467A1,CN(CCCC(=O)c1ccc(CO)cc1)C(=O)OC(C)(C)C.CS(=O)(=O)Cl>>CN(CCCC(=O)c1ccc(COS(C)(=O)=O)cc1)C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20100261698A1,CCS(=O)(=O)Cl.Cn1c(-c2cncc(N)c2)c(C#N)c2ccc(Cl)cc21>>CCS(=O)(=O)Nc1cncc(-c2c(C#N)c3ccc(Cl)cc3n2C)c1,,ClCCl,,CCN(CC)CC,,val
US05741785,CCOC(=O)c1nc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n2c1CBr.CN1CCNCC1>>CCOC(=O)c1nc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n2c1CN1CCN(C)CC1,,CC#N,,,,val
US20070078140A1,Nc1ccc(F)cc1F.O=C(O)c1nccnc1Cl>>O=C(Nc1ccc(F)cc1F)c1nccnc1Cl,,CN(C)C=O,ClCCl,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20110118245A1,CC(C)(F)c1cc(NC(=O)Oc2ccc(Cl)cc2)on1.COc1cc2c(Oc3cccc(N)c3)ncnc2cc1O>>COc1cc2c(Oc3cccc(NC(=O)Nc4cc(C(C)(C)F)no4)c3)ncnc2cc1O,,CN(C)C=O,,,,val
US20100022518A1,COC(=O)C(CCN1CCC2(CC2)[C@H](O)C1)N1CCN(c2cccc(C(F)(F)F)c2)C(C)C1=O>>CC1C(=O)N(C(CO)CCN2CCC3(CC3)[C@H](O)C2)CCN1c1cccc(C(F)(F)F)c1,,CCO,,[BH4-].[Na+],,val
US04634713,CI.O=C1NCCN1c1ccc([N+](=O)[O-])cc1>>CN1CCN(c2ccc([N+](=O)[O-])cc2)C1=O,,CN(C)C=O,,O,[H-].[Na+],val
US20050267095A1,CC(=O)Cl.CCNCC1(c2ccc(OCCCN3CCCC3)cc2)CCOCC1>>CCN(CC1(c2ccc(OCCCN3CCCC3)cc2)CCOCC1)C(C)=O,,C1CCOC1,,CCN(CC)CC,,val
US20130123268A1,CCN(CC)S(F)(F)F.O=C(c1csc(-c2cn[nH]c2)c1)N1C2CCC1CC(O)(c1nccs1)C2>>O=C(c1csc(-c2cn[nH]c2)c1)N1C2CCC1CC(F)(c1nccs1)C2,,ClCCl,,O=C([O-])O.[Na+],,val
US20150065519A1,CC1(C)OB(c2ccncc2NC2CCCC2)OC1(C)C.O=S(=O)(Nc1ccc(-c2csc(Br)n2)c(Cl)c1)C(F)(F)F>>O=S(=O)(Nc1ccc(-c2csc(-c3ccnc(NC4CCCC4)c3)n2)c(Cl)c1)C(F)(F)F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20100105744A1,Br[Mg]C1CC1.O=Cc1ccc(C(F)(F)F)cc1Cl>>OC(c1ccc(C(F)(F)F)cc1Cl)C1CC1,,C1CCOC1,CCOCC,CCOC(C)=O,O,val
US04559345,CCCCCCCCSc1nc(Cl)cc(Cl)n1.Cc1cccc(N)c1C>>CCCCCCCCSc1nc(Cl)cc(Nc2cccc(C)c2C)n1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20080214601A1,COC(=O)c1cc(F)cc2oc(C3CC3)nc12>>O=C(O)c1cc(F)cc2oc(C3CC3)nc12,,CO,,Cl,[Na+].[OH-],val
US20050043392A1,CC#C[C@H](O)[C@@H](N)CNC(=O)OCc1ccccc1.O=C(O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)N1CCC1>>CC#C[C@H](O)[C@H](CNC(=O)OCc1ccccc1)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)N1CCC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030166933A1,BrBr.CCCc1nc2ccccc2c(=O)n1Cc1ccccc1>>CCC(Br)c1nc2ccccc2c(=O)n1Cc1ccccc1,,CC(=O)O,,O,CC(=O)[O-].[Na+],val
US20080318935A1,CC(C)(C)[C@H](N)C(=O)O.CNC.CNC(=O)[C@H](CC(C)C)NC(=O)c1nc(Br)n2c1CN(C)CCC2>>CN1CCCn2c(Br)nc(C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C)c2C1,,C1CCOC1,,,,val
US05576321,ClCCCCOc1cccc2[nH]ccc12.Clc1ccc2c(C3=CCNCC3)c[nH]c2c1>>Clc1ccc2c(C3=CCN(CCCCOc4cccc5[nH]ccc45)CC3)c[nH]c2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090298823A1,CC(C)(C)OC(=O)N1CCC(Nc2nc(Nc3ccc4cn[nH]c4c3)nc3[nH]ccc23)CC1>>c1cc2c(NC3CCNCC3)nc(Nc3ccc4cn[nH]c4c3)nc2[nH]1,,O=C(O)C(F)(F)F,,,,val
US20040214868A1,CC(C)Oc1cc(OCc2cccs2)cc(C(=O)O)c1.CCOC(C)=O.Cc1ccnc(N)c1C>>COC(=O)c1ccc(NC(=O)c2cc(OCc3cccs3)cc(OC(C)C)c2)nc1,,CN(C)C=O,,CCN=C=NCCCN(C)C,,val
US20080188528A1,Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)c2ccc(Cc3ccccc3)cc2)C(=O)OC(C)(C)C)c(C)c2c1OC(C)(C)CC2.O=C(O)C(F)(F)F>>N=C(N)NCCC[C@H](NC(=O)c1ccc(Cc2ccccc2)cc1)C(=O)O.O=C(O)C(F)(F)F,,O,,CC[SiH](CC)CC,,val
US20090270363A1,CCN(C)c1ccc(C#N)cc1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CCN(C)c1ccc(C(N)=S)cc1,,CO,,,,val
US20040106604A1,Cc1ccccc1S(=O)(=O)Cl.OCCCSc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1>>ClCCCSc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1,,c1ccncc1,,O=C([O-])O.[Na+],,val
US20130012491A1,CCOC(=O)CCCc1cc(F)cc(-c2cnc(-c3ccc(OC(C)C)c(C(F)(F)F)c3)nc2)c1OC>>COc1c(CCCC(=O)O)cc(F)cc1-c1cnc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)nc1,,CC(C)O,O,[Na+].[OH-],,val
US06376530B1,Cc1cc(OC(F)(F)F)ccc1C(N)=O>>Cc1cc(OC(F)(F)F)ccc1C#N,,O=P(Cl)(Cl)Cl,,,,val
US20100183603A1,O=C1NC(=O)[C@H](c2c[nH]c3ccccc23)[C@@H]1c1cc2c3c(ccn3CCC2)c1>>O=C1NC(=O)[C@@H](c2c[nH]c3ccccc23)[C@@H]1c1cc2c3c(ccn3CCC2)c1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20110002952A1,CCOC(=O)c1nnc(N)s1.NC1CC1>>Nc1nnc(C(=O)NC2CC2)s1,,CO,,,,val
US20130059834A1,CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C4COC4)c4cc(F)ccc34)nc12>>CC(C)NC(=O)c1c[nH]c2ncc(-c3nn(C4COC4)c4cc(F)ccc34)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150045378A1,CCOC(=O)CC(c1cc(Cl)ncn1)C1CC1.COc1ccc(F)c(-c2ncc(CO)cc2OC2CCCCO2)c1>>CCOC(=O)CC(c1cc(OCc2cnc(-c3cc(OC)ccc3F)c(OC3CCCCO3)c2)ncn1)C1CC1,,C1CCOC1,,Cl,[H-].[Na+],val
US20050250751A1,CC[Mg]Br.COc1cccc2c1CCCC2=O>>Cc1cccc2c(O)cccc12,,CCOCC,,,,val
US20030162724A1,COC(=O)Cc1c(C)[nH]c2cc(C(F)(F)F)ccc12>>Cc1[nH]c2cc(C(F)(F)F)ccc2c1CC(=O)O,,O,,CO,[Na+].[OH-],val
US04859707,CSCC(=O)Nc1c(C)cccc1C.O=C(OO)c1cccc(Cl)c1>>Cc1cccc(C)c1NC(=O)CS(C)=O,,ClCCl,,,,val
US20120071535A1,CCOC(=O)/C=C/c1ccc(B(O)O)cc1.O=C1CCC(=O)N1I>>CCOC(=O)/C=C/c1ccc(I)cc1,,CC#N,CCOC(C)=O,,,val
US20070173519A1,CC(C)(C)[Si](C)(C)Cl.CCOc1ccc(N(C(=O)OC(C)(C)C)c2c(CC(O)CO)c(Cl)nc3ccnn23)cc1>>CCOc1ccc(N(C(=O)OC(C)(C)C)c2c(CC(O)CO[Si](C)(C)C(C)(C)C)c(Cl)nc3ccnn23)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20150218186A1,CSc1ncc2c(=O)[nH]cc(-c3cn(S(=O)(=O)c4ccc(C)cc4)c4cc(C(F)(F)F)ccc34)c2n1.N[C@H]1CCCC[C@H]1N>>Cc1ccc(S(=O)(=O)n2cc(-c3c[nH]c(=O)c4cnc(N[C@@H]5CCCC[C@@H]5N)nc34)c3ccc(C(F)(F)F)cc32)cc1,,O,,,,val
US20060167246A1,COC(=O)c1cc2[nH]ccc2s1.O=C1CCCCC1>>O=C(O)c1cc2[nH]cc(C3=CCCCC3)c2s1,,CO,,C[O-].[Na+],,val
US20040082798A1,COC(=O)c1ccc(C=O)cc1.Cc1ccc(OCc2ccc(Br)cc2)c(CCN)n1>>COC(=O)c1ccc(CNCCc2nc(C)ccc2OCc2ccc(Br)cc2)cc1,,CCO,,O,[BH4-].[Na+],val
US04678781,CO/N=C(\C(=O)NC1C(=O)N2C(C(=O)O)=C(CN=[N+]=[N-])CS[C@H]12)c1csc(N)n1.O=C(O)C(F)(F)F>>CO/N=C(\C(=O)NC1C(=O)N2C(C(=O)O)=C(CN)CS[C@H]12)c1csc(N)n1.O=C(O)C(F)(F)F,[Ni],CO,,,,val
US20160120850A1,O=P(Cl)(Cl)Cl.O=S(=O)(O)c1ccc(Br)c2ccncc12>>O=S(=O)(Cl)c1ccc(Br)c2ccncc12,,O=P(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20050009822A1,CCCCC(C(C)=O)C(=O)OC>>CCCCC(C(C)=O)C(=O)O,,C1COCCO1,,[K+].[OH-],,val
US20100048666A1,CCOC(=O)C(C)c1ccc(C(Cl)C2CCCS2(=O)=O)cc1>>CCOC(=O)C(C)c1ccc(C=C2CCCS2(=O)=O)cc1,,c1ccccc1,,C1CCC2=NCCCN2CC1,,val
US20040132727A1,COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccc(C(C)O)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)OC(C)c4ccc(C)cc4)c(C)c3C)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US20030078251A1,COC(=O)c1cc(NC(=O)C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)COC(C)=O)C2=O)cc2c1CCCC2>>COc1cccc([C@H]2O[C@H](CC(=O)Nc3cc4c(c(C(=O)O)c3)CCCC4)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,O,,CCO,[Na+].[OH-],val
US04736057,CCOC(=O)C[C@@H]1CCC(=O)C[C@@H]1c1ccccc1>>O=CC[C@@H]1CCC(=O)C[C@@H]1c1ccccc1,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20130303500A1,CC(=O)O[C@H]1CC[C@@]2(CO)C(=CCC3C4CCC(=O)[C@@]4(C)CCC32)C1>>CC(=O)O[C@H]1CC[C@@]2(CO)C(CCC3C4CCC(=O)[C@@]4(C)CCC32)C1,[Pd],CO,,[H][H],,val
US20060264460A1,Cc1nc2ccc(N)cc2c(Nc2ccc(F)c(Cl)c2)c1C#N.O=Cc1cccnc1>>Cc1nc2ccc(NCc3cccnc3)cc2c(Nc2ccc(F)c(Cl)c2)c1C#N,,CCO,,[BH3-]C#N.[Na+],,val
US20040058903A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1nc(CCNc2ccc([N+](=O)[O-])cc2)cs1>>Cc1nc(CCN(C(=O)OC(C)(C)C)c2ccc([N+](=O)[O-])cc2)cs1,CN(C)c1ccncc1,C1CCOC1,,,,val
US04018785,CCOC(=O)C(C)c1ccc(Nc2nccs2)c(Cl)c1.CI>>CCOC(=O)C(C)c1ccc(N=c2sccn2C)c(Cl)c1,,CCO,,,,val
US20150322002A1,CS(=O)OCc1cc(F)c(Br)cc1Cl.Oc1ccc(Cl)c(Cl)c1>>Fc1cc(COc2ccc(Cl)c(Cl)c2)c(Cl)cc1Br,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04410534,COC(=O)C1CCCCn2cccc21.O=C(Cl)c1ccccc1>>COC(=O)C1CCCCn2c(C(=O)c3ccccc3)ccc21,,Cc1ccccc1C,,,,val
US06124281,C#CC(=O)OCC.O=Cc1ccc(Cl)cc1[N+](=O)[O-]>>CCOC(=O)C#CC(O)c1ccc(Cl)cc1[N+](=O)[O-],,C1CCOC1,CCOCC,CC(=O)O,[Li]CCCC,val
US20060111347A1,CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)OC(C)(C)C>>CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2N,,CCOC(C)=O,Cl,,,val
US06300334B1,CCc1csc(N)c1C(=O)O.COC(C)(C)OC>>CCOC(=O)c1ccsc1NC(C)C,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20090181929A1,CCN(CC1CCCC1)c1ncc(Br)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1.N#C[Cu]>>CCN(CC1CCCC1)c1ncc(C#N)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1,,CN(C)C=O,,N,,val
US05281571,CO.Cn1nc(-c2cc([N+](=O)[O-])c(F)cc2F)c(Cl)c1C(F)(F)F>>COc1cc(F)c(-c2nn(C)c(C(F)(F)F)c2Cl)cc1[N+](=O)[O-],,O,,O=C([O-])[O-].[K+].[K+],,val
US20150368265A1,CNC(=O)c1c(-c2ccc(OC)nc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc4c(n3)-c3cc5c(F)cccc5n3CO4)cc12>>CNC(=O)c1c(-c2ccc(=O)[nH]c2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc4c(n3)-c3cc5c(F)cccc5n3CO4)cc12,,CC(=O)O,,Br,,val
US20040063954A1,COC1(OC)CCN(c2ccc(N3C[C@@H](CN=[N+]=[N-])OC3=O)cc2F)CC1F>>COC1(OC)CCN(c2ccc(N3C[C@H](CN)OC3=O)cc2F)CC1F,[Pd],CCOC(C)=O,,,,val
US20050026963A1,Fc1cccc(Cl)c1.c1ccc(-c2cc[nH]n2)nc1>>Clc1cccc(-n2ccc(-c3ccccn3)n2)c1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US05843983,CCOC(=O)N1C[C@H](O)C[C@H]1CCOc1ccc(OC)cc1CCc1ccccc1>>COc1ccc(OCC[C@@H]2C[C@@H](O)CN2C)c(CCc2ccccc2)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140094459A1,CC(C)(C)OC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4cc(F)ccc4F)cc3)c3c(N)ncnc32)C1>>Nc1ncnc2c1c(-c1ccc(Oc3cc(F)ccc3F)cc1)nn2[C@@H]1CCCNC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04879288,Nc1ccccc1Sc1ccccc1.O=C(Cl)Oc1ccccc1>>O=C(Nc1ccccc1Sc1ccccc1)Oc1ccccc1,,Cc1ccccc1,,[Na+].[OH-],,val
US20070213341A1,C=C(N=Cc1cc(F)ccc1C)O[Si](C)(C)C.O=C1Nc2cc(F)ccc2/C1=C/c1cccc(Cl)c1>>Cc1ccc(F)cc1C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(F)ccc12,,Cc1ccccc1,,,,val
US20020072528A1,CC(=O)O.Nc1cnc2ccccc2c1S>>Cc1nc2cnc3ccccc3c2s1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20020022605A1,CCCCOc1ccc(S(=O)(=O)N2CC(NCc3ccccc3)C2)cc1.C[C@@H]1OC1Oc1cccc2[nH]c3ccccc3c12>>CCCCOc1ccc(S(=O)(=O)N2CC(N(Cc3ccccc3)CC(O)COc3cccc4[nH]c5ccccc5c34)C2)cc1,,CO,,,,val
US05250678,CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(Oc4ccc5cc(O[Si](C)(C)C(C)(C)C)ccc5c4)C(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(Oc4cccc5ccc(O)cc45)C(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC,,CO,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100081690A1,NC(=O)[C@H]1CCCN(C(=O)OCc2ccccc2)C1.O=C(CBr)c1ccc(F)cc1>>O=C(OCc1ccccc1)N1CCC[C@H](c2nc(-c3ccc(F)cc3)co2)C1,,CN1CCCC1=O,,CCOC(C)=O,,val
US20040229869A1,CSc1ccc(C(=O)c2cccc3ccccc23)cc1>>CSc1ccc(C(O)c2cccc3ccccc23)cc1,,CO,,[BH4-].[Na+],,val
US20070032485A1,CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2cc(Cl)ncn2)C[C@H]1CC.FC(F)(F)c1cc(CBr)cc(C(F)(F)F)c1>>CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2cc(Cl)nc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC,,CC#N,,[H-].[Na+],,val
US05219871,CNCCc1ccc(Cl)cc1.N#CC(CCBr)(c1ccccc1)c1ccccc1>>CN(CCc1ccc(Cl)cc1)CCC(C#N)(c1ccccc1)c1ccccc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110288090A1,CC(=O)OCc1nc(Cl)ccc1NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)Nc1ccc(Cl)nc1CO,,C1COCCO1,O,[Na+].[OH-],,val
US20070004753A1,CS(=O)(=O)c1ccc(NC2(C#N)CCC2)cc1.N#Cc1ccc(N=C=S)cc1C(F)(F)F.O>>CS(=O)(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C23CCC3)cc1,,CN(C)C=O,O,CO,Cl,val
US20040006141A1,CCCCC(Cc1ccc(OCCNC(=O)c2ccc(-c3ccccc3O)cc2)cc1)C(=O)OCC.[Na]>>CCCCC(Cc1ccc(OCCNC(=O)c2ccc(-c3ccccc3O)cc2)cc1)C(=O)[O-].[Na+],,CO,ClCCl,[Na+].[OH-],,val
US20130072473A1,CC(=O)OC(C)=O.Nc1cc2c(c(-c3nc4ccccc4s3)c1)CCN(C(=O)C(F)(F)F)C2>>CC(=O)Nc1cc2c(c(-c3nc4ccccc4s3)c1)CCN(C(=O)C(F)(F)F)C2,,CC(=O)O,,,,val
US04824859,CCOC(C)=O.COc1ccc(NC2=NN(c3ccccc3)CC2)cc1>>COc1ccc(N(C(C)=O)C2=NN(c3ccccc3)CC2)cc1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20150005305A1,COc1cccc(C(CBr)OCCNS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1>>COc1cccc(C2CN(S(=O)(=O)c3ccc([N+](=O)[O-])cc3)CCO2)c1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20150291533A1,COC(=O)C1Cc2ccccc2N(C(=O)OC(C)(C)C)C[C@H]1C>>COC(=O)C1Cc2ccccc2NC[C@H]1C,,ClCCl,O,O=C(O)C(F)(F)F,[Na+].[OH-],val
US05872167,Nc1cccc(O)c1.O=C1C=CC(=O)O1>>O=C(O)/C=C\C(=O)Nc1cccc(O)c1,,Cc1ccccc1C,,,,val
US04349684,CCOC(=O)CCCCCCCl.O=c1[nH]cc(-c2ccccc2)n1-c1ccc(Cl)cc1>>CCOC(=O)CCCCCCn1cc(-c2ccccc2)n(-c2ccc(Cl)cc2)c1=O,,CN(C)C=O,,,,val
US04530930,CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)c(F)c21.c1c[nH]cn1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(-n3ccnc3)c(F)c21,,CN(C)C=O,,,,val
US20080261969A1,Cc1cc2[nH]c(S)nc2cc1Cl.O=Cc1ccc([N+](=O)[O-])o1>>Cc1cc2[nH]c(Sc3ccc(C=O)o3)nc2cc1Cl,,C1CCOC1,,[H-].[Na+],,val
US20140221310A1,O=C(O)Cc1ccc(CBr)cc1.Oc1c(C2CCC2)ccc(-c2cnc3c(c2)OCCN3)c1F>>O=C(O)Cc1ccc(COc2c(C3CCC3)ccc(-c3cnc4c(c3)OCCN4)c2F)cc1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20070161615A1,Cc1ncc(-c2nc(Nc3ccc(N4CCN(C(=O)CO)CC4)cc3)ncc2Cl)n1C(C)C>>Nc1ccc(N2CC(O)C2)cc1,[Pd],,,CCO,,val
US20110166137A1,COc1ccc2cc(-c3ccnc(N(C)C)n3)cc(NC3CCN(C(=O)OC(C)(C)C)CC3)c2c1.Cl>>COc1ccc2cc(-c3ccnc(N(C)C)n3)cc(NC3CCNCC3)c2c1.Cl,,C1COCCO1,,CCOCC,,val
US20140263164A1,C=CCOc1ccc([N+](=O)[O-])c(CO)c1.O=C(OO)c1cccc(Cl)c1>>O=[N+]([O-])c1ccc(OCC2CO2)cc1CO,,ClCCl,,,,val
US20110065681A1,Cc1ccc([C@@H](CO[Si](C)(C)C(C)(C)C)N=[N+]=[N-])cn1>>Cc1ccc([C@H](N)CO[Si](C)(C)C(C)(C)C)cn1,[Pd],CCOC(C)=O,,,,val
US04049813,CNC(=O)c1c(-c2ccccc2)noc1C.Cc1ccc(C=O)cc1>>CNC(=O)c1c(-c2ccccc2)noc1CC(O)c1ccc(C)cc1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US05849755,COc1ccc2c(c1)OC(C)(C)C(NC(=O)c1cc(F)ccc1OC)C2O>>COc1ccc2c(c1)OC(C)(C)C(NC(=O)c1cc(F)ccc1OC)C2,,CCOC(C)=O,ClCCl,,,val
US20140350080A1,CN(C)C=Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1OCCCN(C(=O)OC(C)(C)C)C(N)=NC(=O)OC(C)(C)C.COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1>>COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(N=CN(C)C)ncnc43)[C@H](OCCCN(C(=O)OC(C)(C)C)C(N)=NC(=O)OC(C)(C)C)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1,,ClCCl,c1ccncc1,,,val
US20100063066A1,CC(C)(C)OC(=O)n1ncc2c(N)cccc21.O=C1CCC(=O)N1Cl>>CC(C)(C)OC(=O)n1ncc2c(N)ccc(Cl)c21,,CC#N,,,,val
US20150119385A1,COCCO.N#Cc1cnc(N)cc1F>>COCCOc1cc(N)ncc1C#N,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20150072976A1,COC(=O)c1ccc(-c2nc(CS(=O)(=O)C3CCN(C(=O)OC(C)(C)C)CC3)c(C)o2)cc1>>Cc1oc(-c2ccc(C(=O)O)cc2)nc1CS(=O)(=O)C1CCN(C(=O)OC(C)(C)C)CC1,,CCO,,[Na+].[OH-],,val
US08653089B2,C[C@H](N)c1nc2ccc(F)cc2n1-c1ccccn1.N#Cc1cnc(N)nc1Cl>>C[C@H](Nc1nc(N)ncc1C#N)c1nc2ccc(F)cc2n1-c1ccccn1,,CC(C)O,CO,CCN(C(C)C)C(C)C,,val
US05556864,CNC.c1ccc(OCC2CO2)c(CCCCc2ccc3ccccc3c2)c1>>CN(C)CC(O)COc1ccccc1CCCCc1ccc2ccccc2c1,,C1CCOC1,,,,val
US20070259849A1,CN(C)CCN.Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1NC(=O)c1ccc(Cl)nc1>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1NC(=O)c1ccc(NCCN(C)C)nc1,,CCO,,CCN(CC)CC,,val
US20150344473A1,C[Si](C)(C)CCOCn1c(-c2ccc(N3CCOCC3)nc2)cc2c(-c3ccc(OC4CCOCC4)c(C#N)c3)ncnc21>>N#Cc1cc(-c2ncnc3[nH]c(-c4ccc(N5CCOCC5)nc4)cc23)ccc1OC1CCOCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140275085A1,COc1nc(N2CCC(F)(F)C2)ncc1-c1ccc(Oc2ccnc(-c3cnn(C)c3)c2)c(C)n1>>Cc1nc(-c2cnc(N3CCC(F)(F)C3)[nH]c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1,,CC(=O)O,,Br,,val
US20050250822A1,Cc1cc(C2(C(F)(F)F)C=NC(c3ccccc3)C2)ccc1NC(=O)OC(C)(C)C>>Cc1cc(C2(C(F)(F)F)C=NC(c3ccccc3)C2)ccc1N,,O=C(O)C(F)(F)F,,,,val
US04673692,CC(C)(C)c1cc(C(=O)c2ccccc2)cc(C(C)(C)C)c1O.NNc1ccccc1>>CC(C)(C)c1cc(C(=NNc2ccccc2)c2ccccc2)cc(C(C)(C)C)c1O,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20060009453A1,CNc1nccc(-c2cccnc2Oc2ccc(NC(=O)c3cccc(C#CCN(C)C)c3)cc2C)n1>>CNc1nccc(-c2cccnc2Oc2ccc(NC(=O)c3cccc(CCCN(C)C)c3)cc2C)n1,[Pd],CCO,CCO,[H][H],,val
US20060128756A1,CC(C)[Si](C(C)C)(C(C)C)n1cc(C2(O)CCNCC2)c(-c2ccccn2)c1-c1ccc(F)cc1>>OC1(c2c[nH]c(-c3ccc(F)cc3)c2-c2ccncc2)CCNCC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04725600,COc1ccc(-c2cc(N3CCNCC3)nc(C)n2)cc1OC.NS(=O)(=O)c1cc(C(=O)Cl)c(Cl)cc1Cl>>COc1ccc(-c2cc(N3CCN(C(=O)c4cc(S(N)(=O)=O)c(Cl)cc4Cl)CC3)nc(C)n2)cc1OC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US05712378,COc1ccc(C(O[C@H]2C[C@H](n3cc(C)c(=O)[nH]c3=O)OC2(CO)CO)(c2ccccc2)c2ccc(OC)cc2)cc1>>Cc1cn([C@H]2C[C@H](O)C(CO)(CO)O2)c(=O)[nH]c1=O,,CC(=O)O,O,,,val
US20030092677A1,CC(C)(C)OC(=O)Nc1ccc(-c2ccsc2)cc1NC(=O)CC(=O)c1cccc(C#N)c1>>N#Cc1cccc(C2=Nc3ccc(-c4ccsc4)cc3NC(=O)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05472933,CON=Cc1[nH]ccc1S(=O)(=O)NC(C)(C)C.ClCCl>>CON=Cc1c(S(N)(=O)=O)ccn1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090004185A1,CN.Cc1ccc2c(NCc3ccc(NC(=O)c4ccc(C)nc4)cc3)nc(Cl)nc2c1>>CNc1nc(NCc2ccc(NC(=O)c3ccc(C)nc3)cc2)c2ccc(C)cc2n1,,CC(C)O,,Cl,,val
US20140364413A1,N#Cc1ccc(-c2c(COc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1.[N-]=[N+]=[N-]>>c1ccc2nc(OCc3nc4c(N5CCOCC5)ccnn4c3-c3ccc(-c4nnn[nH]4)nc3)ccc2c1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US05162334,C=CCOC1CC(C=C(C)C2OC(=O)C3CCCCN3C(=O)C(=O)C3(O)OC(C(OC)CC(C)CC(C)=CC(CC)C(=O)CC(O[Si](C)(C)C(C)(C)C)C2C)C(OC)CC3C)CCC1N=[N+]=[N-]>>C=CCOC1CC(C=C(C)C2OC(=O)C3CCCCN3C(=O)C(=O)C3(O)OC(C(OC)CC(C)CC(C)=CC(CC)C(=O)CC(O)C2C)C(OC)CC3C)CCC1N=[N+]=[N-],,CC#N,CCOC(C)=O,,,val
US04533731,Cl.c1ccc2c(NCCCN3CCOCC3)n[nH]c2c1>>Cl.c1ccc2c(NCCCN3CCOCC3)n[nH]c2c1,,CCO,,CCOCC,,val
US20160222030A1,Cc1cnc2ccccc2n1.NC(=O)CCC(=O)NBr>>BrCc1cnc2ccccc2n1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20050070582A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(O)c1ccc(Cl)c(S(=O)(=O)Cl)c1>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2cc(C(=O)O)ccc2Cl)CC1,,ClCCl,,CCN(CC)CC,,val
US20100010053A1,CC(C)Oc1ccc(-c2nc(-c3cccc4c(CCC=O)c[nH]c34)no2)cc1Cl.CNCC(=O)O>>CC(C)Oc1ccc(-c2nc(-c3cccc4c(CCCN(C)CC(=O)O)c[nH]c34)no2)cc1Cl,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120058997A1,CC(C)(C)OC(=O)N1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1=O>>O=C1CC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140135360A1,BrBr.O=Cc1cccc(-c2ccc(Cl)c(Cl)c2)c1O>>O=Cc1cc(Br)cc(-c2ccc(Cl)c(Cl)c2)c1O,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20090233937A1,Cc1ccc(S(=O)(=O)O)cc1.OCCn1ccc2ncnc(Nc3ccc(Oc4cccc5sncc45)c(Cl)c3)c21>>Cc1ccc(S(=O)(=O)OCCn2ccc3ncnc(Nc4ccc(Oc5cccc6sncc56)c(Cl)c4)c32)cc1,,CCO,,CCOC(C)=O,O,val
US04381311,BrBr.Fc1ccc(-c2ccsc2-c2ccc(F)cc2)cc1>>Fc1ccc(-c2cc(Br)sc2-c2ccc(F)cc2)cc1,,CC(=O)O,ClCCl,,,val
US20130085151A1,Cc1cc2cc([C@H](C)N)c(-c3ccccn3)nc2s1.Clc1ncnc2nc[nH]c12>>Cc1cc2cc([C@H](C)Nc3ncnc4[nH]cnc34)c(-c3ccccn3)nc2s1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20110077252A1,CCOC(=O)CC(=O)C(F)(F)F.N=C(N)c1ccc(N)cn1>>Nc1ccc(-c2nc(O)cc(C(F)(F)F)n2)nc1,,CCO,O,O=C([O-])[O-].[Na+].[Na+],,val
US20050165063A1,CCCI.COC(=O)c1ccc(N)c(N)c1>>CCCNc1cc(C(=O)OC)ccc1N,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050282858A1,c1ccc(CN2CCC3(C2)OCc2ccccc23)cc1>>c1ccc2c(c1)COC21CCNC1,[Pd],CO,,,,val
US04921855,O=C(OCc1ccccc1)[C@H](Cc1ccccc1)OC(=O)N1CCSC1.O=C(OO)c1cccc(Cl)c1>>O=C(OCc1ccccc1)[C@H](Cc1ccccc1)OC(=O)N1CCS(=O)C1,,ClCCl,,O=S([O-])[O-].[Na+].[Na+],,val
US20040242875A1,CCN(CC)CCN.O=Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1>>CCN(CC)CCNCc1ccc(-c2ccc(C(F)(F)F)cc2)cc1,[Pd],Cc1ccccc1,,,,val
US20140275026A1,COc1nccc2c(-c3cc(C=O)ccc3F)cn(C)c12.Oc1ccc(F)cc1F>>COc1nccc2c(-c3cc(C=O)ccc3Oc3ccc(F)cc3F)cn(C)c12,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120196872A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1NC(c2ccc(F)cc2)CNC12COCCOC2>>CC(C)(C)OC(=O)N1CC(c2ccc(F)cc2)NC(=O)C12COCCOC2,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20110053932A1,CCOC(=O)c1cccc2c(O)ncnc12.CI>>CCOC(=O)c1cccc2c(OC)ncnc12,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20070208007A1,CCCN(CCC)CCCCNCc1ccc(CNC(=O)OC(C)(C)C)cc1.N#CCBr>>CCCN(CCC)CCCCN(CC#N)Cc1ccc(CNC(=O)OC(C)(C)C)cc1,,CN(C)C=O,,CCN(CC)CC,,val
US04740602,O=Cc1ccc2c(CCCCN3CCC4=C(CCc5ccccc54)C3)c[nH]c2c1>>OCc1ccc2c(CCCCN3CCC4=C(CCc5ccccc54)C3)c[nH]c2c1,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20090093454A1,C=O.CCNCC.CN1CCN(c2cccc3nc(CN4CCC[C@H]5CCc6cccnc6[C@H]54)cn23)CC1>>CCN(CC)Cc1c(CN2CCC[C@H]3CCc4cccnc4[C@H]32)nc2cccc(N3CCN(C)CC3)n12,,O,,CC(=O)O,,val
US20050197342A1,CC1(C)OC(=O)CC(=O)O1.COC(OC)OC.COc1cc(N)ccc1F>>COc1cc(NC=C2C(=O)OC(C)(C)OC2=O)ccc1F,,CC#N,,,,val
US20160159838A1,CC1CCC(C(C)C)C(OP(Cl)Cl)C1.COc1cc(C)cc(-c2cc(C(C)C)c(C)cc2O)c1O>>COc1cc(C)cc2c1op(OC1CC(C)CCC1C(C)C)oc1cc(C)c(C(C)C)cc12,,Cc1ccccc1,,CCN(CC)CC,,val
US05559230,CC(=O)OC(C)=O.NCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1>>CC(=O)NCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1,O=S(=O)(O)O,,,[Na+].[OH-],,val
US20070259910A1,Cc1ccc(-n2nc(C(C)(C)C)cc2N)cc1.NC(=O)c1[nH]c2ccccc2c1-c1ccc(N)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(-c3c(C(N)=O)[nH]c4ccccc34)cc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20070027163A1,Cc1[nH]c2ccccc2c1C(=O)N1CCC(O)(Cc2ccccc2)CC1.Clc1ccccc1CBr>>Cc1c(C(=O)N2CCC(O)(Cc3ccccc3)CC2)c2ccccc2n1Cc1ccccc1Cl,,CN(C)C=O,,[H-].[Na+],,val
US20150329497A1,COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4N)CC3)c2cc1OC.O=CCCl>>COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4NCCCl)CC3)c2cc1OC,CC(=O)O,CCOC(C)=O,CO,[BH3-]C#N.[Na+],,val
US20100075948A1,O=C(O)c1cc(F)c(Cl)cc1F>>OCc1cc(F)c(Cl)cc1F,,C1CCOC1,,B,Cl,val
US04591585,C[C@@H]1CC2=CC(=O)C[C@H](C)[C@]2(C)[C@H]2CC[C@]3(C)C(=O)CC[C@H]3[C@H]12>>CC1=CC(=O)C=C2C[C@@H](C)[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]3[C@@]12C,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20150087646A1,COC(=O)c1ccc(C(N)=O)cc1OC.O=C(Cl)C(=O)Cl>>COC(=O)c1ccc(C(=O)N=C=O)cc1OC,,ClCCCl,,,,val
US20150072969A1,CCOC(=O)CC1(c2ccc(OCc3cccc(Br)c3)cc2)COC1.CSc1ccc(B(O)O)cc1>>CCOC(=O)CC1(c2ccc(OCc3cccc(-c4ccc(SC)cc4)c3)cc2)COC1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20070032529A1,Cl.O=C(NCc1cccnc1)c1cc(NC(=O)c2cc(F)c(F)cc2Cl)[nH]n1>>Cl.O=C(NCc1cccnc1)c1cc(NC(=O)c2cc(F)c(F)cc2Cl)[nH]n1,,CO,,CCOC(C)=O,,val
US03965102,CN1CC=C(C=Cc2ccccc2)CC1.Cl>>CN1CC=C(C=Cc2ccccc2)CC1.Cl,,CCOCC,,CC(C)O,,val
US20130065923A1,Cc1nc(N2CC[C@H](N3CCC[C@@H]3C)C2)ccc1[N+](=O)[O-]>>Cc1nc(N2CC[C@H](N3CCC[C@@H]3C)C2)ccc1N,[Pd],CO,,,,val
US20110178060A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CC(C)(C)OC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CC#N,O,CCN(CC)CC,CN(C)c1ccccn1,val
US04330535,CC(C)(C)C(O)C(Oc1ccc(-c2ccccc2)cc1)n1cncn1.CC[Si](Cl)(CC)CC>>CC[Si](CC)(CC)OC(C(Oc1ccc(-c2ccccc2)cc1)n1cncn1)C(C)(C)C,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,,val
US04940710,O=C(O)c1cn(C2CC2)c2cc(Cl)c(F)cc2c1=O.c1cc(C2CNCCN2)co1>>O=C(O)c1cn(C2CC2)c2cc(N3CCNC(c4ccoc4)C3)c(F)cc2c1=O,,c1ccncc1,,,,val
US05455258,CCOC(=O)CNS(=O)(=O)c1ccc(OC)cc1.COc1ccc(CCl)cc1>>CCOC(=O)CN(Cc1ccc(OC)cc1)S(=O)(=O)c1ccc(OC)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20120202781A1,NC1CCc2cc(Cc3cc(CO)cc(C(F)(F)F)c3)ccc21.O=Cc1ncccc1C(F)(F)F>>OCc1cc(Cc2ccc3c(c2)CCC3NCc2ncccc2C(F)(F)F)cc(C(F)(F)F)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US20110039889A1,CC(C)(C)OC(=O)CCc1nccc2c(C(=N)NO)cccc12.O=C(Cl)c1ccc(OCC2CC2)c(Cl)c1>>CC(C)(C)OC(=O)CCc1nccc2c(-c3noc(-c4ccc(OCC5CC5)c(Cl)c4)n3)cccc12,,CN(C)C=O,,CCN(CC)CC,,val
US20120232056A1,COC(=O)c1ccc2nc(-c3cc(-c4ccccc4)co3)c(N(C)C(C)C)nc2c1>>CC(C)N(C)c1nc2cc(C(=O)O)ccc2nc1-c1cc(-c2ccccc2)co1,,CO,,O,[Na+].[OH-],val
US20090181956A1,COC(=O)NN.Cc1cc(Cl)cc2c(=O)oc(=O)[nH]c12>>COC(=O)NNC(=O)c1cc(Cl)cc(C)c1N,,O,,CO,,val
US20140235647A1,CC(=O)OO.N#Cc1nccc(-c2cncnc2)c1F>>N#Cc1nccc(-c2cncnc2O)c1F,,CC(C)=O,ClCCl,O=S(=O)(O)O,[Na+].[OH-],val
US06248755B1,Fc1ccc2c(c1)ncn2C1CCN(Cc2ccccc2)CC1>>Fc1ccc2c(c1)ncn2C1CCNCC1,[Pd],CO,,O=C[O-].[NH4+],,val
US20050096336A1,CCOC(=O)CCc1ccc(O)c2c1CCCC2.Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1CCl>>CCOC(=O)CCc1ccc(OCc2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)c2c1CCCC2,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05180728,CCc1c(CCNC(=O)n2ccnc2)[nH]c2ccccc12>>CCc1c2n(c3ccccc13)C(=O)NCC2,,Cc1ccccc1,,,,val
US20130096088A1,CCOC(=O)CN(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1)C1CN(C(=O)OC(C)(C)C)C1>>CCOC(=O)CN(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1)C1CNC1,,ClCCl,,C1COCCO1,Cl,val
US20160024065A1,COc1ccc(C)cc1NC(=S)NC(=O)c1ccccc1>>COc1ccc(C)cc1NC(N)=S,,CO,,C[O-].[Na+],,val
US05593983,CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](N5CCSC(C)(C)C5)C[C@]4(C)[C@H]3CC[C@]12C.CS(=O)(=O)O>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](N5CCSC(C)(C)C5)C[C@]4(C)[C@H]3CC[C@]12C.CS(=O)(=O)O,,CO,,,,val
US20040152743A1,N#CBr.NNC(=O)c1ccccc1[N+](=O)[O-]>>Nc1nnc(-c2ccccc2[N+](=O)[O-])o1,,CC#N,,,,val
US04413003,CCCCC(O)(CCl)c1ccc(Cl)cc1Cl.c1c[nH]cn1>>CCCCC(O)(Cn1ccnc1)c1ccc(Cl)cc1Cl,,CN(C)C=O,,O,,val
US20150051410A1,O=C1CCCC=CC[C@@H]2[C@@H](/C=C/[C@H](COc3cccc(C(F)(F)F)c3)OC3CCCCO3)[C@H](OC3CCCCO3)C[C@@H]2O1>>O=C1CCCC=CC[C@@H]2[C@@H](/C=C/[C@@H](O)COc3cccc(C(F)(F)F)c3)[C@H](O)C[C@@H]2O1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120225310A1,CCCCC(CC)COC(=O)C1CC=CCC1C(=O)OCC(CC)CCCC.O=S([O-])O.[Na+]>>CCCCC(CC)COC(=O)C1CCC(S(=O)(=O)[O-])CC1C(=O)OCC(CC)CCCC.[Na+],,CC(C)O,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20110065764A1,CCOC(=O)c1cc(-c2ccc(C(C)(C)C)cc2)on1.O=C1CCC(=O)N1Cl>>CCOC(=O)c1noc(-c2ccc(C(C)(C)C)cc2)c1Cl,,CC(=O)O,,,,val
US05102667,CN(C)c1cc(F)ccc1CC(=O)O.O=C1CCC(c2ccccc2)(c2ccccc2)C2CNCC12>>CN(C)c1cc(F)ccc1CC(=O)N1CC2C(=O)CCC(c3ccccc3)(c3ccccc3)C2C1,,ClCCl,,CCN(CC)CC,Cl,val
US04363816,CCOC(=O)c1c(Nc2ccccc2[N+](=O)[O-])c(C)cn1C>>CCOC(=O)c1c(Nc2ccccc2N)c(C)cn1C,[Ni],CCO,,NN,O,val
US20120178752A1,COC(=O)c1cccc([C@H]2CCCN2C(=O)Nc2cccc(C#N)c2)c1>>N#Cc1cccc(NC(=O)N2CCC[C@@H]2c2cccc(C(=O)O)c2)c1,,CO,,[Na+].[OH-],,val
US20150252044A1,O=C(O)c1ccc2cncc(Br)c2n1.OC1CCNC1>>O=C(c1ccc2cncc(Br)c2n1)N1CCC(O)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US03937738,CC(C)C=O.FC(F)(F)SCl>>CC(C)(C=O)SC(F)(F)F,,ClCCl,,CCO,,val
US20100249163A1,CO[C@]1(c2ccc(F)c(F)c2)CCN(C(=O)OC(C)(C)C)C[C@@H]1C(=O)N(Cc1cccc(Cl)c1Cl)C1CC1.ClCCl>>COCCc1ccc(Cl)c(CN(C(=O)C2CNCCC2(OC)c2ccc(F)c(F)c2)C2CC2)c1,,ClCCl,,Cl,,val
US20100081644A1,CCI.COC(=O)C(C)(C)CO>>CCOCC(C)(C)C(=O)OC,,CN(C)C=O,,[H-].[Na+],,val
US20120010193A1,CC1(C)CC(c2ccccc2)NC1=O.O=C1Nc2ncccc2[C@@]12Cc1cc3ccc(CO)nc3cc1C2>>CC1(C)CC(c2ccccc2)N(Cc2ccc3cc4c(cc3n2)C[C@]2(C4)C(=O)Nc3ncccc32)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20020058644A1,FC(F)(F)c1cccc(CBr)c1.c1ccc2[nH]nnc2c1>>FC(F)(F)c1cccc(Cn2nnc3ccccc32)c1,,CN(C)C=O,O,[Na+].[OH-],,val
US20110201604A1,CCOC(=O)c1ccc2nc(Nc3nc4ccc(Cl)cc4s3)n(C)c2c1>>Cn1c(Nc2nc3ccc(Cl)cc3s2)nc2ccc(C(=O)O)cc21,,C1CCOC1,CO,[Na+].[OH-],,val
US20090264650A1,NCc1c(Cl)cccc1Cl.O=C(O)C1CCN(C2CCCCC2)C1=O>>O=C(NCc1c(Cl)cccc1Cl)C1CCN(C2CCCCC2)C1=O,,CC#N,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US06846827B1,Cc1ccc(NC(=O)c2cccc(N3CCOCC3)c2)cc1Nc1cc(Cl)ncn1>>Cc1ccc(NC(=O)c2cccc(N3CCOCC3)c2)cc1Nc1ccncn1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20090137822A1,C1CCC2=NCCCN2CC1.C1CCOC1.OC1CSC(O)CS1>>O=C(c1ccccc1)c1ccsc1,,ClCCCl,,Cl,,val
US04154740,N#CO[K].NC1CCC(=O)c2ccsc21>>NC(=O)NC1CCC(=O)c2ccsc21,,O,,Cl,,val
US20110256550A1,CC1c2cc(Br)ccc2-c2ccc(Br)cc21.O=C1c2ccccc2C(=O)N1CCCCBr>>CC1(CCCCN2C(=O)c3ccccc3C2=O)c2cc(Br)ccc2-c2ccc(Br)cc21,,CS(C)=O,ClCCl,O,[K+].[OH-],val
US20060223797A1,C#CCCOS(=O)(=O)c1ccc(C)cc1.CN1CCNCC1>>C#CCCN1CCN(C)CC1,,ClCCCl,,O=C([O-])O.[Na+],,val
US20060148048A1,CCC(O)CC(=O)[O-].Sc1ccccc1>>CCC(O)CC(=O)Oc1cccs1,,ClCCl,,C[Al](C)C,Cl,val
US20030225283A1,CS(=O)(=O)c1ccc(C(CC2CCCC2OC2CCCCO2)C(=O)Nc2nccs2)cc1>>CS(=O)(=O)c1ccc(C(CC2CCCC2O)C(=O)Nc2nccs2)cc1,,CCO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20110275611A1,Cn1nccc1NC(=O)[C@H]1CCCN(c2cc(-c3ccc(C#N)c(F)c3)nc(N)n2)C1.NN>>Cn1nccc1NC(=O)[C@H]1CCCN(c2cc(-c3ccc4c(N)n[nH]c4c3)nc(N)n2)C1,,CCO,,CCN(C(C)C)C(C)C,,val
US03931268,CN(C(=O)OCc1ccccc1)N(Cc1ccc(C(=O)Cl)cc1)C(=O)OCc1ccccc1.NC1CC1>>CN(C(=O)OCc1ccccc1)N(Cc1ccc(C(=O)NC2CC2)cc1)C(=O)OCc1ccccc1,,c1ccccc1,,CCN(CC)CC,Cl,val
US05359066,COC(=O)C=CN(C)C.O=C(Cl)c1cc(F)c(F)c(F)c1F>>COC(=O)C(=CN(C)C)C(=O)c1cc(F)c(F)c(F)c1F,,CCN(CC)CC,,C1COCCO1,,val
US20150274718A1,COC(=O)C(OC(C)(C)C)c1c(C(F)(F)F)ccc(-c2ccccc2)c1-c1ccc2c(c1)CCCO2>>CC(C)(C)OC(C(=O)O)c1c(C(F)(F)F)ccc(-c2ccccc2)c1-c1ccc2c(c1)CCCO2,,C1CCOC1,CO,[Li+].[OH-],,val
US20080076794A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc(C2CCCc3cncn32)c1>>c1cc(C2CCCc3cncn32)c[nH]1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20080221062A1,CC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1.CC(O)C(N)(O)C(=O)OC(C)(C)C.Cl>>CC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1.Cl.NCC(O)CO,,ClCCl,,CCCCCC,CCOC(C)=O,val
US05118704,CCCN(CCCN1C(=O)c2ccccc2C1=O)C1CCc2c(cccc2OC)C1>>CCCN(CCCN1C(=O)c2ccccc2C1=O)C1CCc2c(O)cccc2C1,,[NH4+],[OH-],Cl,c1ccncc1,val
US20110053972A1,Cn1nccc1-c1cc(C(=O)NC(CNC(=O)OC(C)(C)C)Cc2ccccc2)c(-c2ccoc2)s1>>Cn1nccc1-c1cc(C(=O)NC(CN)Cc2ccccc2)c(-c2ccoc2)s1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20060135523A1,NC1CCC(F)(F)CC1.O=C(O)c1cnc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)n1>>O=C(NC1CCC(F)(F)CC1)c1cnc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)n1,,ClCCl,,,,val
US20030092739A1,ClCc1ccc(Cl)nc1.N#CN>>N#CNCc1ccc(Cl)nc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US03936464,Cl.OC1(c2ccc(C(F)(F)F)cc2)CCNCC1>>Cl.FC(F)(F)c1ccc(C2=CCNCC2)cc1,,CC(=O)O,,,,val
US20090029965A1,Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1/C=C/C(=O)OC(C)(C)C>>Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1/C=C/C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160221945A1,CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)ncc1C(N)=O>>CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)ncc1C#N,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20140221339A1,COCC(=O)Nc1cccc(C(=O)OC)c1N>>COCc1nc2c(C(=O)OC)cccc2[nH]1,,CC(=O)O,,,,val
US20040132721A1,CCOc1ccc(C2=NN(c3ccc(C(=O)N4CCN(c5ccccc5)CC4)cc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OCC.c1ccc(N2CCNCC2)nc1>>CCOc1ccc(C2=NN(c3ccc(C(=O)N4CCN(c5ccccn5)CC4)cc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OCC,,CCOCC,,Cl,,val
US20080194535A1,C=CC[C@@H](C(=O)OC)N(C)C(=O)CCCCC>>C=CC[C@@H](C(=O)O)N(C)C(=O)CCCCC,,C1CCOC1,,O,[Li+].[OH-],val
US20110054017A1,COC(=O)CCCCCCNC(=O)c1cc(-c2ccccc2)oc1C.O=C1CCC(=O)N1Br>>COC(=O)CCCCCCNC(=O)c1c(C)oc(-c2ccccc2)c1Br,,ClCCCl,,,,val
US05521192,CCCCCCCCCCC(=O)Nc1cc(-c2c(N)nc(N)nc2CC)ccc1Cl>>CCCCCCCCCCCNc1cc(-c2c(N)nc(N)nc2CC)ccc1Cl,,C1CCOC1,,Cl,[Na+].[OH-],val
US20050070441A1,COC(=O)CC(=O)c1ccc(Cl)cc1.NN>>Oc1cc(-c2ccc(Cl)cc2)[nH]n1,,CCO,,O,,val
US04643990,CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCCCCCC)CC(=O)N[C@H](C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O)C(C)C>>CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCCCCCC)CC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C,,CC(=O)O,,Br,,val
US20110108819A1,Oc1c(-c2nc3ccccc3s2)ccc2ccccc12.c1ccc(B(OB(c2ccccc2)c2ccccc2)c2ccccc2)cc1>>c1ccc(B(Oc2ccc3ccccc3c2-c2nc3ccccc3s2)c2ccccc2)cc1,,C1CCOC1,,,,val
US20120220589A1,COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCCc4cc(S(=O)(=O)N(C)C)ccc43)nc2c1>>CN(C)S(=O)(=O)c1ccc2c(c1)CCCN2c1nc2cc(C(=O)O)ccc2nc1-c1ccc(F)cc1,,CO,O,[Na+].[OH-],,val
US06355653B1,N#CC=Cc1ccncc1.O=S(=O)(Cc1n[nH]c(-c2ccccc2)n1)c1ccccc1>>Nc1cc(-c2ccncc2)cc2nc(-c3ccccc3)nn12,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20050004167A1,CCOc1cccc2cc(C(=O)NN)oc12.O=S(=O)(Cl)c1ccccc1>>CCOc1cccc2cc(C(=O)NNS(=O)(=O)c3ccccc3)oc12,CN(C)c1ccncc1,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20070161834A1,OCC#Cc1ccccc1>>OCCCc1ccccc1,,C1CCOC1,,[H][H],,val
US20070032551A1,CN(C)CC1CCCCC1c1cccc(O)c1.O=C(O)/C=C/C(=O)O>>CN(C)CC1CCCCC1c1cccc(O)c1.O=C(O)/C=C/C(=O)O,,CCOC(C)=O,,,,val
US20080113966A1,CC(=O)Cc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)OC(C)(C)C.C[Mg]Br>>CC(C)(O)Cc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)OC(C)(C)C,,C1CCOC1,,,,val
US05187192,COc1cccc(C2CC(N(OC(C)=O)C(C)=O)C2)c1>>COc1cccc(C2CC(N(O)C(C)=O)C2)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20030039838A1,CCCC1(CCC)c2ccccc2-c2ccc(-c3ccc4c(c3)C(CCC)(CCC)c3cc(-c5ccc6c(c5)C(CC(C)CC)(CC(C)CC)c5cc([Si](C)(C)C)ccc5-6)ccc3-4)cc21.ClI>>CCCC1(CCC)c2ccccc2-c2ccc(-c3ccc4c(c3)C(CCC)(CCC)c3cc(-c5ccc6c(c5)C(CC(C)CC)(CC(C)CC)c5cc(I)ccc5-6)ccc3-4)cc21,,ClC(Cl)(Cl)Cl,,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20110257137A1,Nc1ccc(Cl)cc1-c1ccc[nH]1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=c1[nH]c2ccc(Cl)cc2c2cccn12,,CO,ClCCl,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US20160075710A1,CC(c1cnn(-c2ccccc2)c(=O)c1-c1ccccc1)n1nc(I)c2c(N)ncnc21.OB(O)c1cc(O)cc(F)c1>>CC(c1cnn(-c2ccccc2)c(=O)c1-c1ccccc1)n1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20050256198A1,CCCCCCCN(Cc1ccc(F)cc1F)C(=O)CCc1ccc(OCc2ccccc2C(=O)OC)cc1>>CCCCCCCN(Cc1ccc(F)cc1F)C(=O)CCc1ccc(OCc2ccccc2C(=O)O)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US06943184B2,CO.COC(=O)C1(C(=O)O)CC1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COC(=O)NC1(C(=O)OC)CC1,,Cc1ccccc1,,CCN(CC)CC,,val
US20160108310A1,CI.c1ccc2[nH]nnc2c1>>Cn1nc2ccccc2n1,,CO,,O,C[O-].[Na+],val
US20070123535A1,CC(C)(C)COC(=O)CC(=O)[O-].O=Cc1c[nH]c2cccnc12>>COC(=O)C(=Cc1c[nH]c2cccnc12)C(=O)OC(C)(C)C,,CC#N,,C1CCNCC1,CC(=O)O,val
US05179111,CC(C)Br.CCOC(=O)c1cn(-c2cccc(O)c2)cn1>>CCOC(=O)c1cn(-c2cccc(OC(C)C)c2)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04195093,COC(=O)CBr.Oc1cccc2c1CCCC2>>COC(=O)COc1cccc2c1CCCC2,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100130495A1,CC(C)(C)OC(=O)N1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(NC[C@@H]3CCCO3)c2C1>>c1ncc(-c2ccc(Nc3nc4c(c(NC[C@@H]5CCCO5)n3)CNCC4)cc2)o1,,CO,,Cl,,val
US05453533,CC(=O)Nc1c(O)cc(C(=O)O)cc1[N+](=O)[O-].Cl>>CC(=O)Nc1ccc(C(=O)O)cc1N.Cl,[Pd],CCO,,NN,O,val
US20070066542A1,c1ccc(COc2ccc(Oc3ccc(-c4c[nH]c(COc5ccccc5)n4)cc3)cc2)cc1>>Oc1ccc(Oc2ccc(-c3c[nH]c(COc4ccccc4)n3)cc2)cc1,[Pd],CCO,,,,val
US04404137,Cn1cc(C#N)c(N)n1.O=[N+]([O-])c1cc(Cl)ccc1Cl>>Cn1cc(C#N)c(Nc2ccc(Cl)cc2[N+](=O)[O-])n1,,C1CCOC1,,O,[H-].[Na+],val
US04214094,CCOC(=O)C(C)(C)Oc1ccc(CN(Cc2ccccc2)c2ccc(Cl)cc2)cc1>>CC(C)(Oc1ccc(CN(Cc2ccccc2)c2ccc(Cl)cc2)cc1)C(=O)O,,CCO,,[Na+].[OH-],,val
US20030032671A1,Cc1ccc(NC(=O)CN(Cc2ccc(OC(C)(C)C(=O)OC(C)(C)C)cc2)Cc2ccco2)c(C)c1>>Cc1ccc(NC(=O)CN(Cc2ccc(OC(C)(C)C(=O)O)cc2)Cc2ccco2)c(C)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04978699,CC1(C)CC(N)CC(C)(C)N1.O=C1OC(=O)c2c(Cl)c(Cl)c(Cl)c(Cl)c21>>CC1(C)CC(NC(=O)c2c(Cl)c(Cl)c(Cl)c(Cl)c2C(=O)O)CC(C)(C)N1,,CC(=O)OC(C)=O,,CC(=O)O,,val
US20110237791A1,CC(C)CBr.OCCc1ccc(Br)cc1>>CC(C)COCCc1ccc(Br)cc1,,CS(C)=O,,O,[K+].[OH-],val
US20060205672A1,CC(C)(C)OC(=O)[C@@H]1CCC(=O)N1C(=O)OC(C)(C)C.CI>>CC1C[C@@H](C(=O)OC(C)(C)C)N(C(=O)OC(C)(C)C)C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100034773A1,Nc1ccc2c(c1)S(=O)(=O)N=C(C1=C(O)[C@@H]3[C@H]4CC[C@H](C4)[C@@H]3N(Cc3ccc(F)cc3)C1=O)N2.O=C=NS(=O)(=O)Cl.OCc1ccccc1>>O=C(NS(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(C1=C(O)[C@@H]3[C@H]4CC[C@H](C4)[C@@H]3N(Cc3ccc(F)cc3)C1=O)N2)OCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20150218124A1,COc1cc(C#N)c(Sc2ccc(C(=O)O)cc2)c(C#N)c1O>>N#Cc1cc(O)c(O)c(C#N)c1Sc1ccc(C(=O)O)cc1,,ClCCl,,BrB(Br)Br,CO,val
US20080280875A1,CCOC(=O)CCC(=O)OCC.Cc1cc(C=O)cs1>>CCOC(=O)C(=Cc1csc(C)c1)CC(=O)O,,CCO,,C,C[O-].[Na+],val
US20020099068A1,CC(C)c1ccc2c(c1)[nH]c1cnccc12.Cl>>CC(C)c1ccc2c(c1)[nH]c1cnccc12.Cl,,CCOCC,ClCCl,,,val
US20110092459A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1nc2c(CBr)cccc2s1.CCOC(OCC)[C@H](C)N>>CCOC(OCC)[C@H](C)NCc1cccc2sc(NC(=O)OC(C)(C)C)nc12,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090270351A1,C=CP(=O)(C(C)C)C(C)C.COc1ccc(CNC(=O)OC(C)(C)C)cc1>>COc1ccc(CN(CCP(=O)(C(C)C)C(C)C)C(=O)OC(C)(C)C)cc1,,C1CCOC1,,[H-].[Na+],,val
US04978665,CCCCOc1cc(CN)ccc1OC.CCOc1n[nH]c(=O)c(Cl)c1Cl>>CCCCOc1cc(CNc2c(OCC)n[nH]c(=O)c2Cl)ccc1OC,,O,,C1COCCO1,,val
US20040162331A1,CCOC(=O)CP(=O)(OCC)OCC.COCOc1cc(C=O)ccc1OC>>CCOC(=O)/C=C/c1ccc(OC)c(OCOC)c1,,CN(C)C=O,,C1CCOC1,[H-].[Na+],val
US04925865,O=C(C=Cc1ccc(Cl)cc1)C1(Sc2ccccc2)CC1>>O=C(CCc1ccc(Cl)cc1)C1(Sc2ccccc2)CC1,,Cc1ccccc1,,[H][H],,val
US20140148466A1,CC(C)(C)C(N)C(=O)c1ccc(C#N)cc1.Cc1cccc(N2CCNCC2)n1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cccc(N2CCN(C(=O)NC(C(=O)c3ccc(C#N)cc3)C(C)(C)C)CC2)n1,,ClCCl,,Cl,,val
US20050171132A1,CCc1nc(N)nc(N)c1-c1ccc(N)cc1.O=C(O)C1Cc2ccccc2C1>>CCc1nc(N)nc(N)c1-c1ccc(NC(=O)C2Cc3ccccc3C2)cc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US04006137,CC1N(C)C=C[NH+]1C.O=Cc1cccc2ccccc12.[I-]>>CN1C=C[NH+](C)C1C=Cc1cccc2ccccc12.[I-],,CO,,O,[K+].[OH-],val
US05646173,C[C@@H](O)CN.O=CCC1Cc2ccc(Br)cc2C1=O>>C[C@@H](O)Cn1ccc2c1-c1cc(Br)ccc1C2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20030087874A1,COc1ccc(Cn2c(=O)ccn([C@@H]3OC([C@H](O)[C@H](NCCCNC(=O)[C@H](Cc4ccccc4)NC(=O)OCc4ccccc4)C(=O)OC(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]3O[Si](C)(C)C(C)(C)C)c2=O)cc1>>COc1ccc(Cn2c(=O)ccn([C@@H]3OC([C@H](O)[C@H](NCCCNC(=O)[C@@H](N)Cc4ccccc4)C(=O)OC(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]3O[Si](C)(C)C(C)(C)C)c2=O)cc1,[Pd],CO,,,,val
US20110021489A1,C1CSCCN1.COC(=O)C1CC(c2ccc(CC(F)(F)F)cc2)CN(C(=O)Oc2ccc([N+](=O)[O-])cc2)C1>>COC(=O)C1CC(c2ccc(CC(F)(F)F)cc2)CN(C(=O)N2CCSCC2)C1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20130345218A1,CC(C)(C)OC(=O)N[C@@H]1CCC[C@H](Nc2nc(Cl)c(C#N)cc2F)C1.Cc1ccc(S(=O)(=O)n2cc(B3OC(C)(C)C(C)(C)O3)c3cc(F)cnc32)cc1>>Cc1ccc(S(=O)(=O)n2cc(-c3nc(N[C@H]4CCC[C@@H](NC(=O)OC(C)(C)C)C4)c(F)cc3C#N)c3cc(F)cnc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,O,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20080058356A1,CI.COC(=O)Cc1ccc(OC)c(OC)c1>>COC(=O)C(C)c1ccc(OC)c(OC)c1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20130072677A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C(C(=O)OCC)N(C)Cc1ccccc1>>CCOC(=O)C(C(=O)OCC)N(C)C(=O)OC(C)(C)C,[Pd],CCO,,[H][H],,val
US20110237784A1,CC(=O)c1cccc(O)c1.Cc1cccc([Mg]Cl)c1>>Cc1cccc(C(C)(O)c2cccc(O)c2)c1,,C1CCOC1,,,,val
US20140121200A1,CC(=O)[C@H]1CCN(C(=O)OC(C)(C)C)C1>>CC(O)[C@H]1CCN(C(=O)OC(C)(C)C)C1,,CO,,[BH4-].[Na+],,val
US20100092952A1,CC(C)(C)[Si](C)(C)Cl.Nc1ccn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1>>CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)C[C@@H]1O,,c1ccncc1,,,,val
US20140315911A1,C[C@H]1Nc2nc(Cl)ncc2NC1=O.N#Cc1cccc(B(O)O)c1>>C[C@H]1Nc2nc(Cl)ncc2N(c2cccc(C#N)c2)C1=O,,ClCCl,,CCN(CC)CC,,val
US20140206680A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1NCc2c(F)c(F)nc(Cl)c21>>CC(C)(C)OC(=O)N1Cc2c(F)c(F)nc(Cl)c2C1=O,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20140221393A1,CC/C=C/CCO.Cc1ccc(S(=O)(=O)Cl)cc1>>CC/C=C/CCOS(=O)(=O)c1ccc(C)cc1,CN(C)c1ccncc1,,,CCN(CC)CC,,val
US20080114006A1,CC(C)(C)OC(=O)NNC1CCCC1.COC(CC(OC)OC)OC>>c1cnn(C2CCCC2)c1,,O,,Cl,,val
US20160264562A1,CCOC(=O)[C@@H](C)OC(=O)C1=C(CN2CCOCC2)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br>>CCOC(=O)C1=C(CN2CCOCC2)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br,,CCO,,[Li],,val
US20080207666A1,CC1(C)CC(NC(=O)C(C)(C)C)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(C(=O)NN)cc3Cl)nc2O1.O=C(Cl)Cl>>CC1(C)CC(NC(=O)C(C)(C)C)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(-c4n[nH]c(=O)o4)cc3Cl)nc2O1,,ClCCl,,,,val
US06294569B2,CCCI.Nc1ccc2c(c1)C(=O)NC2=O>>CCCN1C(=O)c2ccc(N)cc2C1=O,,CN(C)C=O,,O,[H-].[Na+],val
US04665179,NCCN.O=C(O)CCS(=O)(=O)C1=CC([N+](=O)[O-])([N+](=O)[O-])CC=C1Cl>>NCCNc1ccc([N+](=O)[O-])cc1S(=O)(=O)CCC(=O)O,,CC(C)O,,,,val
US20110319594A1,O=C(CNC(=O)CNC(=O)OCc1ccccc1)NCC(=O)NCC(=O)OCc1ccccc1>>NCC(=O)NCC(=O)NCC(=O)NCC(=O)O,[Pd],CN(C)C=O,,,,val
US05643927,Cc1cc(=O)c2ccc(O)cc2o1.ClCCCBr>>Cc1cc(=O)c2ccc(OCCCCl)cc2o1,,CC(C)=O,CCOCC,O=C([O-])[O-].[K+].[K+],,val
US20070259881A1,CCOCc1nc2cnc3ccccc3c2n1CC1CCN(C)O1>>CCOCc1nc2cnc3ccccc3c2n1CC(O)CCNC,[Pd],CC(=O)O,CO,CC(C)O,,val
US20070082912A1,CC(=O)CCC(=O)c1cc(C)ccc1OCc1ccc(F)cc1.COC(=O)c1cc(N)cc(N)c1C>>COC(=O)c1cc(-n2c(C)ccc2-c2cc(C)ccc2OCc2ccc(F)cc2)cc(N)c1C,,CCOC(C)=O,CN1CCCC1=O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150197493A1,C=CC[Sn](CCCC)(CCCC)CCCC.COC(=O)c1ccc(Br)c(S(=O)(=O)N2CCCC(OCc3ccccc3)CC2)c1>>C=CCc1ccc(C(=O)OC)cc1S(=O)(=O)N1CCCC(OCc2ccccc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCOC(C)=O,O,val
US20070232583A1,C1CCNC1.Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(=O)(=O)Cl)c3)n2)n1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(=O)(=O)N4CCCC4)c3)n2)n1,,C1CCOC1,CCOC(C)=O,,,val
US20100152183A1,CC(C)[Si](Cl)(C(C)C)C(C)C.c1ccc(COc2ccc3cc[nH]c3c2)cc1>>CC(C)[Si](C(C)C)(C(C)C)n1ccc2ccc(O)cc21,,C1CCOC1,,[H-].[Na+],,val
US20140296203A1,Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc(N)ncc23)ccn1.F[Xe]F>>Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3c(F)c(N)ncc23)ccn1,,C1CCOC1,,,,val
US20120196872A1,CC(C)(C)OC(=O)N1CC(c2ccc(F)cc2)N(CC(=O)O)C(=O)C12COCCOC2.Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21>>O=C(CN1C(=O)C2(COCCOC2)NCC1c1ccc(F)cc1)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US09221804B2,COc1nc2ccc(Br)cc2c(Cl)c1Cc1ccc(F)cc1.Cc1ccc(C=O)c(C)n1>>COc1nc2ccc(C(O)c3ccc(C)nc3C)cc2c(Cl)c1Cc1ccc(F)cc1,,C1CCOC1,,[Li]CCCC,,val
US20060183780A1,COC(=O)c1ccsc1N.O=c1c2ccnn2c(=O)c2ccnn12>>COC(=O)c1ccsc1NC(=O)c1cc[nH]n1,,C1CCOC1,,O,[H-].[Na+],val
US20120232155A1,CCc1cc(OC)c(Oc2ccc(C(N)=O)cc2F)cc1F>>CCc1cc(O)c(Oc2ccc(C(N)=O)cc2F)cc1F,,ClCCl,,BrB(Br)Br,,val
US20160264570A1,Nc1cnc2ccc(Br)cc2c1Nc1cccc(C(F)(F)F)c1.O=C(Cl)OC(Cl)(Cl)Cl>>O=c1[nH]c2cnc3ccc(Br)cc3c2n1-c1cccc(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,,val
US04734406,CCCCCC.O=Cc1cccnc1>>c1ccc2ccccc2c1,,CCOCC,,Cl,[Li]CCCC,val
US06610705B1,CCCCN.COc1ccc(C(c2ccc(OCC3CO3)cc2)C2CCCc3ccccc32)cc1>>CCCCNCC(O)COc1ccc(C(c2ccc(OC)cc2)C2CCCc3ccccc32)cc1,,CCO,,,,val
US20080188528A1,COC(=O)[C@@H](N)CCCNC(=N)NS(=O)(=O)c1ccc(C)cc1.O=C(O)c1cccn(C(c2ccccc2)c2ccccc2)c1=O>>COC(=O)[C@H](CCCNC(=N)NS(=O)(=O)c1ccc(C)cc1)NC(=O)c1cccn(C(c2ccccc2)c2ccccc2)c1=O,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100137338A1,COC(=O)c1ccc(-c2cnnn2C)cc1>>Cn1nncc1-c1ccc(C(=O)O)cc1,,C1CCOC1,,[Na+].[OH-],,val
US04643758,CC(C)(C)c1coc(N)c1C#N.CC(CCCl)C(=O)Cl>>CC1CCN(c2occ(C(C)(C)C)c2C#N)C1=O,,Cc1ccccc1,,,,val
US20050203081A1,COC(=O)CS.COC(=O)c1cc(I)cnc1Cl>>COC(=O)c1sc2ncc(I)cc2c1O,,CN(C)C=O,,O,C[O-].[Na+],val
US05554607,CC(C)NCC(=O)O.CC(C)c1ccccc1N=C=S>>CC(C)c1ccccc1N1C(=O)CN(C(C)C)C1=S,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20100056530A1,COC(=O)CCc1csc(Nc2ncc(Br)cc2OCc2ccccc2)n1>>O=C(O)CCc1csc(Nc2ncc(Br)cc2OCc2ccccc2)n1,,C1CCOC1,O,[Na+].[OH-],,val
US20040259888A1,O=[N+]([O-])c1ccccc1OB(O)O.OC1CCN(c2ncnc3oc(-c4ccc(Br)cc4)c(-c4ccccc4)c23)CC1>>O=[N+]([O-])c1ccccc1-c1ccc(-c2oc3ncnc(N4CCC(O)CC4)c3c2-c2ccccc2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20160052884A1,CC1(C=O)COC1.COc1cn(CC(=O)OC(C)(C)C)c(=O)cc1-c1cc(Cl)ccc1C#N>>COc1cn(C(=CC2(C)COC2)C(=O)OC(C)(C)C)c(=O)cc1-c1cc(Cl)ccc1C#N,,CN(C)C=O,,[H-].[Na+],,val
US20090306066A1,CN1CCN(C(=O)OCc2ccccc2)[C@H]2CCCC[C@H]21>>CN1CCN[C@H]2CCCC[C@H]21,,CO,,,,val
US20160083379A1,CN1CCN(c2cccc(N(C)c3ccc(O)cc3)c2)CC1.Oc1nc(Cl)nc2cnccc12>>CN1CCN(c2cccc(N(C)c3ccc(Oc4nc(O)c5ccncc5n4)cc3)c2)CC1,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130289033A1,COc1ccccc1B(O)O.O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(I)cc1>>COc1ccccc1-c1ccc(C(=O)NCCc2c[nH]c3ccc(Cl)cc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20150175615A1,C=CCN(CC(=O)O)NC(=O)NCc1ccccc1.CCOC(CN(Cc1cccc(F)n1)C(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1)OCC>>C=CCN(CC(=O)N[C@@H](Cc1ccc(OC(C)(C)C)cc1)C(=O)N(Cc1cccc(F)n1)CC(OCC)OCC)NC(=O)NCc1ccccc1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050075357A1,Fc1cc(F)c(-c2c(Cl)nc(-n3ccnc3)nc2Cl)c(F)c1.NCC(F)(F)F>>Fc1cc(F)c(-c2c(Cl)nc(-n3ccnc3)nc2NCC(F)(F)F)c(F)c1,,CN(C)C=O,,[Cl-].[Na+],,val
US20110112103A1,CC(C)(C)OC(=O)c1nc(CCl)nc(O)c1OCc1ccccc1.COCCl>>COCOc1nc(CCl)nc(C(=O)OC(C)(C)C)c1OCc1ccccc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20140228348A1,N#CCC1(n2cc(C(N)=O)c(N)n2)CCC2(CC1)OCCO2>>N#CCC1(n2cc(C(N)=O)c(N)n2)CCC(=O)CC1,,C1CCOC1,CCOC(C)=O,Cl,O=C([O-])O.[Na+],val
US20110130409A1,CCOC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(OC(C)C)c(C#N)c3)cc21>>CC(C)Oc1ccc(COc2ccc3[nH]c4c(c3c2)CCC4CC(=O)O)cc1C#N,,C1COCCO1,,Cl,[Li+].[OH-],val
US20120309735A1,Cc1cc(Nc2nccc(O[C@@H]3CCN(C(=O)OC(C)(C)C)C3)n2)cc(-c2cnc(N3CCCNC(=O)C3)s2)c1>>Cc1cc(Nc2nccc(O[C@@H]3CCNC3)n2)cc(-c2cnc(N3CCCNC(=O)C3)s2)c1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20120316337A1,CCCC[Mg]Br.O=C(O)c1ccc2ccccc2c1F>>CCCCc1c(C(=O)O)ccc2ccccc12,,C1CCOC1,,Cl,O,val
US20120184539A1,CCN(CC)S(F)(F)F.O=C1COCC(CO)(c2cc(Br)cnc2Cl)N1>>O=C1COCC(CF)(c2cc(Br)cnc2Cl)N1,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20030225125A1,Nc1ccc(Cl)c(C(=O)O)c1.O=C=Nc1ccccc1Br>>O=C(Nc1ccc(Cl)c(C(=O)O)c1)Nc1ccccc1Br,,CN(C)C=O,,,,val
US20120202783A1,CC(C)(C)OC(=O)N1CC2CNCC21.O=C(O)c1ccccc1-c1ccccc1>>CC(C)(C)OC(=O)N1CC2CN(C(=O)c3ccccc3-c3ccccc3)CC21,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140051692A1,C=CCN1CCOc2ccc(-c3c([C@H](OC(C)(C)C)C(=O)OC)c(C)nc4cc(-c5cccc(Br)c5)nn34)c(Cl)c21.CC1(C)OB(c2ccccc2O)OC1(C)C>>C=CCN1CCOc2ccc(-c3c([C@H](OC(C)(C)C)C(=O)OC)c(C)nc4cc(-c5cccc(-c6ccccc6O)c5)nn34)c(Cl)c21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20160002248A1,ClI.O=C(O)c1cn(CCCCc2cc3cc(C4CC4)[nH]c3nn2)nn1>>O=C(O)c1cn(CCCCc2cc3c(I)c(C4CC4)[nH]c3nn2)nn1,,ClCCl,,,,val
US20150232454A1,CCOc1ncc(Br)cc1OC.OB(O)C1=CCCCC1>>O=c1[nH]cc(C2CCCCC2)cc1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20080009482A1,CN1CCC(N)CC1.Nc1ccc(C(=O)O)cc1F>>CN1CCC(NC(=O)c2ccc(N)c(F)c2)CC1,,CN(C)C=O,CO,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100267946A1,CCCC(Cl)OC(=O)NCC1(CC(=O)O)CCCCC1.OCc1ccccc1>>CCCC(Cl)OC(=O)NCC1(CC(=O)OCc2ccccc2)CCCCC1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05990160,O=C1OC(=O)c2c1cc(=O)c(O)c(O)c2O>>O=C(O)c1cc(O)c(O)c(O)c(=O)c1,,O,,,,val
US04070539,CC=C(C)C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl>>CC1C(=O)c2c(cc(OCC(=O)O)c(Cl)c2Cl)C1C,,O=S(=O)(O)O,,,,val
US20120035163A1,CS(=O)(=O)c1ccc(Br)nc1.O=[N+]([O-])c1ccc(O)cc1OC1CCOCC1>>CS(=O)(=O)c1ccc(Oc2ccc([N+](=O)[O-])c(OC3CCOCC3)c2)nc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050043351A1,CC(C)(C#N)c1ccc2c(c1)CCC2NC(=O)Nc1cccc2[nH]ncc12>>CC(C)(C#N)c1ccc2c(c1)CC[C@H]2NC(=O)Nc1cccc2[nH]ncc12,,CO,,,,val
US20070270422A1,C=O.O=C(c1ccc(Oc2ccc(NCc3ccc(C(F)(F)F)cc3)cn2)cc1)N1CCN(Cc2ccccc2)CC1>>CN(Cc1ccc(C(F)(F)F)cc1)c1ccc(Oc2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)cc2)nc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US05932599,CCCNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NCCC)n1.Cl>>CCCNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NCCC)n1.Cl,,CO,,,,val
US20110207773A1,Nc1cccc(F)n1.O=C(O)c1cc(-c2ccc(Cl)cc2)nc2ccccc12>>O=C(Nc1cccc(F)n1)c1cc(-c2ccc(Cl)cc2)nc2ccccc12,,ClCCl,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US20090029965A1,Cc1cc(C(=O)O)ccc1CCCC(=O)N1CCN(CCC(C)(C)C)CC1.Cn1ncc2c1Nc1ccccc1NC2>>Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CCCC(=O)N1CCN(CCC(C)(C)C)CC1,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US06114332,COC(=O)c1ccccc1I.Nc1cc(Br)ccc1C(=O)O>>COC(=O)c1ccccc1Nc1cc(Br)ccc1C(=O)O,,CO,O,,,val
US20110105509A1,COC(=O)CCC(=O)C(=O)OC.NNCc1ccc(C(F)(F)F)cc1>>COC(=O)C1=NN(Cc2ccc(C(F)(F)F)cc2)C(=O)CC1,Cl,CCO,,NN,,val
US20130244999A1,CC1Cc2ccc(C3=CCNCC3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1.N#Cc1ccnc(Cl)c1>>CC1Cc2ccc(C3=CCN(c4cc(C#N)ccn4)CC3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1,,CN(C)C=O,CO,CCN(C(C)C)C(C)C,,val
US20050154000A1,Cc1cccc(I)c1.N#CC1(N2CCC3(CC2)C(=O)NCC3c2ccccc2)CCCCC1>>Cc1cccc(C2(N3CCC4(CC3)C(=O)NCC4c3ccccc3)CCCCC2)c1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20030171396A1,CC(=O)OC(C)=O.CC(C)(C)NS(=O)(=O)CCCCO>>CC(=O)OCCCCS(=O)(=O)NC(C)(C)C,,c1ccncc1,,,,val
US20090054405A1,CC(=O)Nc1nc2ccc(-c3ccnc(Cl)n3)cc2s1.CC(C)(N)c1ccccc1>>CC(=O)Nc1nc2ccc(-c3ccnc(NC(C)(C)c4ccccc4)n3)cc2s1,,ClCCl,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060052599A1,OCc1ccc(NC2CCN(Cc3ccccc3)C2)nc1>>O=Cc1ccc(NC2CCN(Cc3ccccc3)C2)nc1,O=[Mn]=O,CCOC(C)=O,,,,val
US20150057276A1,CC(C)(C)C(=O)Nc1ccc(F)c(C(O)c2ccc3nccnc3c2)c1F>>CC(C)(C)C(=O)Nc1ccc(F)c(C(=O)c2ccc3nccnc3c2)c1F,O=[Mn]=O,ClCCl,,,,val
US20090181946A1,CC(C)(C)OC(=O)N[C@@H]1CCc2ccccc2NC1=O.O=C1CCC(=O)N1Cl>>CC(C)(C)OC(=O)N[C@@H]1CCc2cc(Cl)ccc2NC1=O,,CCOC(C)=O,,,,val
US20070249670A1,CC(C)(C)OC(=O)[C@@H](NC(=O)c1ccc(-c2ccccc2)cc1N)C1CCCCC1.O=C=Nc1c(Cl)cc(Cl)cc1Cl>>CC(C)(C)OC(=O)[C@@H](NC(=O)c1ccc(-c2ccccc2)cc1NC(=O)Nc1c(Cl)cc(Cl)cc1Cl)C1CCCCC1,,c1ccncc1,,,,val
US20110135668A1,Cc1c[nH]c2nc(Cl)nc(Cl)c12.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)n2cc(C)c3c(Cl)nc(Cl)nc32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20060084640A1,N=C(N)N1CCN(c2ncccc2C(F)(F)F)CC1.O=C(C(=O)c1ccc(C(F)(F)F)cc1)c1ccccc1>>FC(F)(F)c1ccc(-c2[nH]c(N3CCN(c4ncccc4C(F)(F)F)CC3)nc2-c2ccccc2)cc1,,CO,,CCN(C(C)C)C(C)C,,val
US20100022780A1,BrBr.CNC(=O)c1cccc(C)c1N>>CNC(=O)c1cc(Br)cc(C)c1N,,O,,CC(=O)O,[Na+].[OH-],val
US04179505,COCCN.COc1ccc(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1[N+](=O)[O-]>>COCCNc1ccc(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1[N+](=O)[O-],,O,,Cl,Cl,val
US20120209006A1,CCC=CN1CCCC1=O.COC(=O)c1cccnc1>>CCC=CN1CCC(C(=O)c2cccnc2)C1=O,,CN(C)C=O,,,,val
US20130172384A1,CC1(C)OB(c2ccc3[nH]ccc3c2)OC1(C)C.O=C(C1CC1)N1CC[C@@H](Cn2c(-c3ccc(Br)cc3F)n[nH]c2=O)C1>>O=C(C1CC1)N1CC[C@@H](Cn2c(-c3ccc(-c4ccc5[nH]ccc5c4)cc3F)n[nH]c2=O)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US20080194617A1,Cc1nn(C)c(-n2ccc3cc(Cl)ccc32)c1CCO.O=C1c2ccccc2C(=O)N1O>>Cc1nn(C)c(-n2ccc3cc(Cl)ccc32)c1CCON1C(=O)c2ccccc2C1=O,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050032786A1,CC(C)(C)OC(=O)NCCc1ccnc(C#N)c1.COC(=O)c1ccccc1S>>CC(C)(C)OC(=O)NCCc1ccnc(-c2nc(=O)c3ccccc3s2)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20140249126A1,C1CCNC1.CCn1cc(C=O)c(=O)c2ccc(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)c21>>CCn1cc(CN2CCCC2)c(=O)c2ccc(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)c21,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20020103229A1,Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1.O=C(Cl)c1ccccc1>>O=C(Nc1cccc(-c2n[nH]c3ccc(-c4nc[nH]n4)cc23)c1)c1ccccc1,,c1ccncc1,,O,,val
US20140031336A1,CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccccn2)C[C@@H]1C.NC(CO)CO>>CC(=O)N1c2ccc(-c3ccc(C(=O)NC(CO)CO)cc3)cc2[C@H](Nc2ccccn2)C[C@@H]1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04439225,C#N.CC1=CCCC(C)(COCc2ccccc2)O1>>CC1(C#N)CCCC(C)(COCc2ccccc2)O1,,c1ccncc1,,,,val
US06458779B1,Cc1ccc2cc(F)ccc2c1.O=C1CCC(=O)N1Br>>Fc1ccc2cc(CBr)ccc2c1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20100216780A1,NNC(=O)c1ccc(Br)o1.S=C=S>>Sc1nnc(-c2ccc(Br)o2)o1,,O,,CO,[K+].[OH-],val
US04223025,CCOP(=S)(Cl)OCC.Oc1nc(F)c(Cl)cc1Cl>>CCOP(=S)(OCC)Oc1nc(F)c(Cl)cc1Cl,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20080221110A1,C=CB1OB(C=C)OB(C=C)O1.OCC1COc2cc(Cl)nnc2O1>>C=Cc1cc2c(nn1)OC(CO)CO2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O,c1ccncc1,val
US04514416,COc1cc(C(=N)N)ccc1OS(C)(=O)=O.O=C(NCc1ccc(C(=O)O)cc1)OCc1ccccc1>>COc1cc(C(=N)N)ccc1OC(=O)c1ccc(CNC(=O)OCc2ccccc2)cc1,,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20050277791A1,CCC(=O)c1ccc(OCc2ccccc2)cc1.O=S(=O)(Cl)Cl>>CC(Cl)C(=O)c1ccc(OCc2ccccc2)cc1,,O,,ClCCl,,val
US20060229348A1,COC(=O)Cl.NC[C@@H]1CN(c2ccc3c(c2)CC(=O)N3CC2CC2)C(=O)O1>>COC(=O)NC[C@H]1CN(c2ccc3c(c2)CC(=O)N3CC2CC2)C(=O)O1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020040003A1,CCOC(=O)C(F)Br.CN(C(=O)OCc1ccccc1)c1cc(C[C@H](NS(=O)(=O)c2ccccc2)C(=O)NCCCCc2ccccc2)ccc1O>>CCOC(=O)C(F)Oc1ccc(C[C@H](NS(=O)(=O)c2ccccc2)C(=O)NCCCCc2ccccc2)cc1N(C)C(=O)OCc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US08138186B2,C1CCNCC1.Clc1ccc(-n2ccc(OCCOCCBr)n2)cc1Cl>>Clc1ccc(-n2ccc(OCCOCCN3CCCCC3)n2)cc1Cl,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US05698575,O=c1c(I)coc2ccccc12.c1ccc2[nH]cnc2c1>>O=c1cc(-c2nc3ccccc3[nH]2)oc2ccccc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050038056A1,NC(N)=O.NCc1c(F)cccc1C(F)(F)F>>NC(=O)NCc1c(F)cccc1C(F)(F)F,,O,,Cl,,val
US20050143381A1,COc1c(-c2ccc(Cl)cc2)cnn(Cc2ccccc2)c1=O.O=P(Cl)(Cl)Cl>>O=c1c(Cl)c(-c2ccc(Cl)cc2)cnn1Cc1ccccc1,,CO,,,,val
US20140294805A1,CC(=O)NCc1ccc(S(=O)(=O)c2cnn(C(C)C)c2)cc1.Cl>>CC(C)n1cc(S(=O)(=O)c2ccc(CN)cc2)cn1.Cl,,CC(C)O,,,,val
US20130131132A1,COc1ccc2c(c1)C(Cc1ccccc1)C(N)CC2>>NC1CCc2ccc(O)cc2C1Cc1ccccc1,,ClCCl,,BrB(Br)Br,,val
US20090175794A1,COC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)NCc1ccc(I)cc1>>COC(=O)CC[C@H](N)C(=O)NCc1ccc(I)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20070078164A1,CCOC(=O)N1CC[C@H](c2cccc(-c3ccccc3)c2)[C@@H](OCc2ccc(C)cc2OCCCOC)C1>>COCCCOc1cc(C)ccc1CO[C@H]1CNCC[C@@H]1c1cccc(-c2ccccc2)c1,,CCO,,[Na+].[OH-],,val
US05096700,N[C@@H](CC(=O)OCc1ccccc1)[C@@H](F)C(=O)NCC(=O)OCc1ccccc1>>C[C@H](N)[C@@H](F)C(=O)NCC(=O)O,[Pd],CO,,,,val
US20030109459A1,COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1(Cc2ccccc2)CCCC1>>COC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)C1(Cc2ccccc2)CCCC1,,CCO,,,,val
US20140349994A1,COc1ccc(Cn2ncc3c2N(Cc2ccc(N4CCOCC4)cn2)CCc2sc(Nc4ncc(F)cn4)nc2-3)cc1>>Fc1cnc(Nc2nc3c(s2)CCN(Cc2ccc(N4CCOCC4)cn2)c2n[nH]cc2-3)nc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US04936121,CC1=CC(=O)OC(C)(C)O1.COC(=O)C=C1CCCCCN1>>COC(=O)c1c2n(c(C)cc1=O)CCCCC2,,Cc1ccccc1C,,,,val
US20160002224A1,CCOC(=O)OC(C#Cc1cc(-c2ccc(OCc3ccccc3)cc2F)c(Cl)cc1NC(=O)C(F)(F)F)c1ccc(C)c(C(=O)OC)c1>>COC(=O)c1cc(Cc2cc3cc(-c4ccc(OCc5ccccc5)cc4F)c(Cl)cc3[nH]2)ccc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,CCOC(C)=O,CCN(CC)CC,O=CO,val
US05840917,CCOC(=O)c1ccoc1C>>Cc1occc1C(=O)O,,CCO,,[Na+].[OH-],,val
US20070066588A1,O=c1cccnn1-c1ccc2nc(C3CC(O)C3)sc2c1>>O=C1CC(c2nc3ccc(-n4ncccc4=O)cc3s2)C1,,ClCCl,O,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20020025959A1,CCOC=C(C(=O)OCC)C(=O)c1cc(I)cc(F)c1F.CN(N)C(=O)OC(C)(C)C>>CCOC(=O)C(=CNN(C)C(=O)OC(C)(C)C)C(=O)c1cc(I)cc(F)c1F,,CC(C)(C)O,,,,val
US20090263407A1,CCCCC/C=C\C/C=C\CCCCCCCCOS(C)(=O)=O.OCC(O)CN1CCCC1>>CCCCC/C=C\C/C=C\CCCCCCCCOCC(O)CN1CCCC1,,Cc1ccccc1,,[H-].[Na+],,val
US20090163524A1,O=C1c2ccccc2C(=O)N1C(Cc1nccn1C(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1>>NC(Cc1nccn1C(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1,,CO,,NN,O,val
US05436260,CCCCc1ncc(/C=C2\NC(=O)N(CCCC)C2=O)n1Cc1ccc(C(=O)OC)cc1.Cc1nc(CCl)cs1.Cl.Cl>>CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1.Cl.Cl,,CCOCC,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20160214956A1,COCCBr.O=Cc1ccc(O)cc1>>COCCOc1ccc(C=O)cc1,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130156732A1,COC(=O)N[C@H](C(=O)N1C[C@@H](C)C[C@H]1c1nc2ccc3cc4c(cc3c2[nH]1)OCc1cc(-c2cnc([C@@H]3C[C@H](C)CN3C(=O)OC(C)(C)C)[nH]2)ccc1-4)C(C)C>>COC(=O)N[C@H](C(=O)N1C[C@@H](C)C[C@H]1c1nc2ccc3cc4c(cc3c2[nH]1)OCc1cc(-c2cnc([C@@H]3C[C@H](C)CN3)[nH]2)ccc1-4)C(C)C,,CCO,,Cl,,val
US05620999,COc1ccc(-c2nc(C(F)(F)F)[nH]c2-c2ccc(SC)cc2)cc1F.O=S([O-])OO>>COc1ccc(-c2nc(C(F)(F)F)[nH]c2-c2ccc(S(C)(=O)=O)cc2)cc1F,,O,,CO,,val
US20090131467A1,CC(C(=O)c1c(O)c2cccnc2n(-c2cccc(OC(F)(F)F)c2)c1=O)c1ccccc1.NN>>CC(c1ccccc1)c1n[nH]c2c1c(=O)n(-c1cccc(OC(F)(F)F)c1)c1ncccc21,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20120046285A1,COC(=O)c1ccc(CCC(=O)O)cc1.COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CN)c3Cl)cccc2n1Cc1ccccn1>>COC(=O)c1ccc(CCC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(OC)n4Cc3ccccn3)c2Cl)cc1,,CCOC(C)=O,CN1CCCC1=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130261178A1,BrCc1ccccc1.CC(=O)c1ccc(O)c(C(N)=O)c1>>CC(=O)c1ccc(OCc2ccccc2)c(C(N)=O)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060217380A1,CNCCCN(C)C.O=[N+]([O-])c1cc(Cl)ccc1Cl>>CN(C)CCCN(C)c1ccc(Cl)cc1[N+](=O)[O-],,Cl,,,,val
US04329518,CC(=O)Cl.Cc1ccc([N+](=O)[O-])c(C)c1CO>>CC(=O)OCc1c(C)ccc([N+](=O)[O-])c1C,,Cc1ccccc1,,Cl,c1ccncc1,val
US20100105658A1,CCOC(=O)c1csc(C)n1.O=C1CCC(=O)N1Br>>CCOC(=O)c1nc(C)sc1Br,,CC#N,,O=C([O-])O.[Na+],,val
US20100152441A1,CC(C)(C)OC(=O)NC1CCNCC1.Fc1ccc(F)c(/C=C/CCl)c1>>CC(C)(C)OC(=O)NC1CCN(C/C=C/c2cc(F)ccc2F)CC1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20070173501A1,CC1(C)O/C(=C2/C(=O)Nc3cc(F)ccc32)C=C1c1ccnc(F)c1.OCCOCCN1CCNCC1>>CC1(C)O/C(=C2/C(=O)Nc3cc(F)ccc32)C=C1c1ccnc(N2CCN(CCOCCO)CC2)c1,,CS(C)=O,,O,,val
US05939439,COC(=O)c1ccc(C#N)c(OCCNC(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)NCCOc1cc(CO)ccc1C#N,,C1CCOC1,,[BH4-].[Li+],,val
US20160237090A1,Cc1noc(C2CN(c3cnn4c3CN(C(=O)OC(C)(C)C)[C@@H](C)C4)C(=O)O2)n1.O=C(Nc1cc(F)c(F)c(F)c1)Oc1ccccc1>>Cc1noc(C2CN(c3cnn4c3CN(C(=O)Nc3cc(F)c(F)c(F)c3)[C@@H](C)C4)C(=O)O2)n1,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US04273782,CN(C)Cc1c[nH]c2ccc(Cl)cc12.c1c[nH]cn1>>Clc1ccc2[nH]cc(Cc3ncc[nH]3)c2c1,,Cc1ccccc1C,,,,val
US20020183364A1,O=C1Cc2cc(Cl)ccc2N1.O=Cc1cc2ccccc2[nH]1>>O=C1Nc2ccc(Cl)cc2C1=Cc1cc2ccccc2[nH]1,,CCO,,C1CCNCC1,,val
US20130059833A1,Cc1ccc(-c2nc(CCN=[N+]=[N-])c(C)s2)cc1>>Cc1ccc(-c2nc(CCN)c(C)s2)cc1,O,,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05736487,O=[N+]([O-])c1ccc(OCc2nc3ccccc3s2)cc1>>Nc1ccc(OCc2nc3ccccc3s2)cc1,,CCO,,Cl,[Na+].[OH-],val
US20150353581A1,CC(N)(C#N)COc1ccc2c(c1OC(F)(F)F)B(O)OC2.O=C(O)c1ccc(OC(F)(F)F)cc1>>CC(C#N)(COc1ccc2c(c1OC(F)(F)F)B(O)OC2)NC(=O)c1ccc(OC(F)(F)F)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090131681A1,NCC(=O)O.O=C(Cl)OCC1c2ccccc2-c2ccccc21>>O=C(O)CNC(=O)OCC1c2ccccc2-c2ccccc21,,C1COCCO1,,O,,val
US20150203486A1,CC#CC(=O)OCC.COCN(Cc1ccccc1)C[Si](C)(C)C>>CCOC(=O)C1=C(C)CN(Cc2ccccc2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060287291A1,CN(C)CCNc1cc([N+](=O)[O-])cc2ccoc12>>CN(C)CCNc1cc(N)cc2ccoc12,[Ni],C1CCOC1,CCO,NN,,val
US20160108026A1,CCO.COC(=O)c1cccc2c1OCC(c1cncc(O)c1)O2>>CCOc1cncc(C2COc3c(cccc3C(=O)OC)O2)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020188122A1,Cc1ccccc1S.NC=O.O=Cc1ccc(F)cc1>>Cc1ccccc1SCN(C=O)c1ccc(F)cc1,,CCOC(C)=O,O,Cc1ccccc1,,val
US20090226940A1,CC(=O)OC(C)=O.Nc1ccc2c(N)c3ccccc3nc2c1>>CC(=O)Nc1ccc2c(N)c3ccccc3nc2c1,,ClCCl,,CCN(CC)CC,,val
US20060223995A1,CCCCCCOS(=O)(=O)CCCCCC.Cn1ccnc1>>CCCCCCS(=O)(=O)[O-].CCCCCCn1cc[n+](C)c1,,Cc1ccccc1,,,,val
US20140194431A1,CC(C)(C)[Si](C)(C)OCCNC1CC1.O=C(O)c1nc(CC2(c3ccccc3)CCCC2)nc(O)c1OCc1ccccc1>>CC(C)(C)[Si](C)(C)OCCN(C(=O)c1nc(CC2(c3ccccc3)CCCC2)nc(O)c1OCc1ccccc1)C1CC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04009175,CN(C)O.O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1Cl)=NCc1nnc(CCl)n1-2>>CN(C)Cc1nnc2n1-c1ccc([N+](=O)[O-])cc1C(c1ccccc1Cl)=NC2,,CN(C)C=O,,[H-].[Na+],,val
US20100280268A1,COC(=O)c1cc(Oc2ccc(CNS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cc2)ccc1NS(=O)(=O)c1ccc(C)cc1>>Cc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(CNS(=O)(=O)c4ccc([N+](=O)[O-])cc4)cc3)cc2C(=O)O)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20020013468A1,Brc1cnc2ccccc2c1.C#CCO>>OCC#Cc1cnc2ccccc2c1,[Cu]I,O=C([O-])O,[Na+],CCN(CC)CC,,val
US20150299194A1,CC(=O)Cl.CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)OCCN>>CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)OCCNC(C)=O,,ClCCl,,CCN(CC)CC,,val
US20070293490A1,CC(=O)Cl.COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C1(C(N)=O)CCNCC1>>COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C1(C(N)=O)CCN(C(C)=O)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US20130079412A1,CC(=O)C(C)C.COC(=O)CC(=O)OC>>COC(=O)C(C(=O)OC)=C(C)C(C)C,Cl[Ti](Cl)(Cl)Cl,ClC(Cl)Cl,,O,c1ccncc1,val
US07439242B2,CCOC(=O)c1cc(NS(=O)(=O)c2ccc(Cl)cc2)ccc1Oc1cncc(Cl)c1>>O=C(O)c1cc(NS(=O)(=O)c2ccc(Cl)cc2)ccc1Oc1cncc(Cl)c1,,CO,O,[Li+].[OH-],,val
US20150218181A1,Brc1nnc2n1CCNC2.COS(=O)(=O)OC>>CN1CCn2c(Br)nnc2C1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20100113528A1,CCOC(=O)C(C)(C)Cn1ncc2cc(-c3noc(-c4cnc(OC(C)C)c(Cl)c4)n3)ccc21>>CC(C)Oc1ncc(-c2nc(-c3ccc4c(cnn4CC(C)(C)C(=O)O)c3)no2)cc1Cl,,CCO,O,CC(=O)O,[Na+].[OH-],val
US04735949,NCC1CN(Cc2ccccc2)CC1c1ccccc1>>NCC1CNCC1c1ccccc1,[Pd],CO,,[H][H],,val
US20030130305A1,BrCCBr.COC(=O)c1cc(O)c(O)cn1>>COC(=O)c1cc2c(cn1)OCCO2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120232056A1,COC(=O)c1ccc2nc(-c3nc4ccccc4o3)c(N(C)C(C)C)nc2c1>>CC(C)N(C)c1nc2cc(C(=O)O)ccc2nc1-c1nc2ccccc2o1,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20040019210A1,CCOC(=O)C1CCC(O)CC1.COc1cc(OC)c(F)c(N2Cc3cnc(SC)nc3NC2=O)c1F>>CCOC(=O)C1CCC(N2C(=O)N(c3c(F)c(OC)cc(OC)c3F)Cc3cnc(SC)nc32)CC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160024027A1,Brc1ccc(-c2nc[nH]n2)cc1.FC(F)(F)Oc1ccc(I)cc1>>FC(F)(F)Oc1ccc(-n2cnc(-c3ccc(Br)cc3)n2)cc1,[Cu]I,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120141414A1,CC(C)(C)OC(=O)CCCCCBr.COC(=O)c1cccc(-c2cccc(O)c2)n1>>COC(=O)c1cccc(-c2cccc(OCCCCCC(=O)OC(C)(C)C)c2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04824839,COc1ccc2c(c1)CC(=O)NCC2.Cl>>COc1ccc2c(c1)CCNCC2.Cl,,C1CCOC1,,B,,val
US20060276433A1,NNc1ccc(-c2cnco2)cc1.O=Cc1ccc(CN2CCOCC2)cc1>>C(=NNc1ccc(-c2cnco2)cc1)c1ccc(CN2CCOCC2)cc1,,CCO,,,,val
US05268377,CCCc1nc2c(n1Cc1ccc(-c3ccccc3C(=O)OC(C)(C)C)cc1)C(C(=O)OCC)N(C(=O)CC(=O)OCC)CC2>>CCCc1nc2c(n1Cc1ccc(-c3ccccc3)c(C(=O)O)c1)C(C(=O)OCC)N(C(=O)CC(=O)OCC)CC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130324516A1,NCCN1CCCC1.Nc1ncnc2ccc(-c3cccc(C(=O)O)c3)nc12>>Nc1ncnc2ccc(-c3cccc(C(=O)NCCN4CCCC4)c3)nc12,,ClCCl,,O=S(Cl)Cl,,val
US20100311748A1,N#Cc1ccccc1OCc1ccc(C(=O)O)cc1.O=S(Cl)Cl>>N#Cc1ccccc1OCc1ccc(C(=O)Cl)cc1,CN(C)C=O,,,,,val
US20090088419A1,CCc1nc(CC(C)(C)C)c(C#N)c(-c2ccc(C)cc2)c1C(=O)OC>>CCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(=O)OC,[Ni],CO,,N,,val
US06184180B2,CCOC(=O)CCCCCCCCCCBr.CN(C)C=O.Oc1ccc(O)c(-c2ccccc2COCc2ccccc2-c2cc(O)ccc2O)c1>>CCOC(=O)CCCCCCCCCCOc1ccc(OCc2ccccc2)cc1,,CN(C)C=O,,[I-].[K+],,val
US20060040999A1,CO.O=C(O)C(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>COC(=O)C(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,c1ccccc1,,C[Si](C)(C)C=[N+]=[N-],,val
US20060276504A1,C1CC[C@H]2CCNC[C@@H]2C1.COc1ccc2oc(C(=O)C(C)(C)C)c(CC(=O)O)c2c1>>COc1ccc2oc(C(=O)C(C)(C)C)c(CC(=O)N3CC[C@@H]4CCCC[C@H]4C3)c2c1,,CN(C)C=O,ClCCCl,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US20060217387A1,CCOC(=O)CC(=O)c1ccc(Cl)cc1.Nc1ccn[nH]1>>Oc1cc(-c2ccc(Cl)cc2)nc2ccnn12,,CCOC(C)=O,,,,val
US20070259881A1,CNO.O=Cc1ccccc1>>C[N+]([O-])=Cc1ccccc1,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US05945436,CC(C)C(C#N)(CCc1ccccc1)c1cccnc1.S>>C#CCC(CCc1ccccc1)(C(N)=S)c1cccnc1,,Cc1ccccc1,,CCNCC,,val
US20070191364A1,O=C(c1ccncc1)N1CCC2(CC1)OCCO2>>O=C1CCN(C(=O)c2ccncc2)CC1,,Cl,,O=C([O-])[O-].[Na+].[Na+],,val
US05034417,CC(=O)c1ccc(NS(C)(=O)=O)c(Sc2ccc(Cl)cc2Cl)c1>>CC(O)c1ccc(NS(C)(=O)=O)c(Sc2ccc(Cl)cc2Cl)c1,,C1CCOC1,CO,CC(=O)O,[BH4-].[Na+],val
US20150031673A1,Brc1cnn(C2COC2)c1.CC(C)(C)[Si](C)(C)Oc1ccc(N)cc1>>CC(C)(C)[Si](C)(C)Oc1ccc(Nc2cnn(C3COC3)c2)cc1,,C1CCOC1,,,,val
US05032677,CN(C)C=O.CO.COc1cc(OCc2ccccc2)ccc1-c1cc(C(=O)O)nc(C(=O)O)c1>>COC(=O)c1cc(-c2ccc(OCc3ccccc3)cc2OC)cc(C(=O)OC)n1,CN(C)C=O,ClCCl,O,Cl,O=C(Cl)C(=O)Cl,val
US20090182007A1,CC1(C)NC(=O)c2ccccc2C1n1ccnc1.CI>>CN1C(=O)c2ccccc2C(n2ccnc2)C1(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20100286123A1,COc1cc(C(O)CBr)ncc1C#N>>COc1cc(C2CO2)ncc1C#N,,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US20080039426A1,CCOC(=O)C(C)(C(C)=O)c1ccc(N)c(NC)c1C#N.S=C=Nc1c(Cl)cccc1Cl>>CCOC(=O)C(C)(C(C)=O)c1ccc2nc(Nc3c(Cl)cccc3Cl)n(C)c2c1C#N,,C1CCOC1,,,,val
US20100317651A1,C[C@@H]1COCCN1c1cnc(C=O)c(Cl)n1.OCCNCc1ccccc1>>C[C@@H]1COCCN1c1cnc(CN(CCO)Cc2ccccc2)c(Cl)n1,,CC#N,CC(=O)O,O=C([O-])O.[Na+],,val
US05661155,CCOC(=O)CC[C@H](NC(=O)c1ccc(OCc2ccc3ccc4nc(C)[nH]c(=O)c4c3c2)cc1)C(=O)OCC>>Cc1nc2ccc3ccc(COc4ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc4)cc3c2c(=O)[nH]1,,CCO,,Cl,[Na+].[OH-],val
US20100063038A1,CCCCOC(=O)c1cc(-c2ccc(N)cc2)c2c(N)ncnn12.O=C(Nc1cccc(C(F)(F)F)n1)Oc1ccccc1>>CCCCOC(=O)c1cc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)n3)cc2)c2c(N)ncnn12,,CN(C)C=O,,CCN(CC)CC,,val
US20090239810A1,CC(=O)c1ccccc1OCc1ccccc1.CCOC(=O)C(=O)OCC>>CCOC(=O)C(=O)CC(=O)c1ccccc1OCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20150376176A1,C1CCNCC1.CC(C)(COc1cccc2c1C(N)=NS(=O)(=O)N2)NC(=O)c1ccnc(Br)c1>>CC(C)(COc1cccc2c1C(N)=NS(=O)(=O)N2)NC(=O)c1ccnc(N2CCCCC2)c1,,C1CCNCC1,,,,val
US20050026998A1,CC(=O)OC(C)=O.CN(C)c1ccncc1>>CC1CC(O)OC(C)O1,CN(C)c1ccncc1,,,c1ccncc1,,val
US20050148627A1,C1N2CN3CN1CN(C2)C3.Cc1cc(C(=O)O)ccc1O.O>>Cc1cc(C(=O)O)cc(C=O)c1O,,CS(=O)(=O)O,,,,val
US20110312936A1,CCC(O)C1CCC(=O)CC1.O=C(CNc1cnnc2ccc(C(F)(F)F)cc12)NC1CNC1>>CCC(O)C1CCC(N2CC(NC(=O)CNc3cnnc4ccc(C(F)(F)F)cc34)C2)CC1,,ClCCl,,CCN(CC)CC,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120068168A1,Brc1ccccc1I.c1ccc2c(c1)[nH]c1ccccc12>>Brc1ccccc1-n1c2ccccc2c2ccccc21,I[Cu]I,Cc1ccccc1C,,O=C([O-])[O-].[K+].[K+],,val
US20020019554A1,O=C(O)c1ccc([N+](=O)[O-])cc1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3.SCc1ccccc1>>O=[N+]([O-])c1ccc(C(=S)SCc2ccccc2)cc1,,Cc1ccccc1,,,,val
US20040133008A1,CC(N)c1ccccn1.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>CC(NC(=O)c1ccc([N+](=O)[O-])cc1)c1ccccn1,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20130225561A1,N#Cc1ccc2c(c1)CC[C@H](N1CCNCC1)C2.O=[N+]([O-])c1ccc(CCBr)cc1>>N#Cc1ccc2c(c1)CC[C@H](N1CCN(CCc3ccc([N+](=O)[O-])cc3)CC1)C2,,CN(C)C=O,,CCN(CC)CC,,val
US20110207777A1,CCO[C@@H]1CC[C@@H](N2CCC(Nc3cc(C)cc(F)c3[N+](=O)[O-])CC2)CC1>>CCO[C@@H]1CC[C@@H](N2CCC(Nc3cc(C)cc(F)c3N)CC2)CC1,[Ni],CCO,,NN,O,val
US20060004069A1,CCC(=O)CBr.NC(=S)Cc1ccc([N+](=O)[O-])cc1>>CCc1csc(Cc2ccc([N+](=O)[O-])cc2)n1,,CCO,,,,val
US06248770B1,Cc1nc2ccccc2[nH]1.O=[N+]([O-])c1cc(CCl)ccc1Cl>>Cc1nc2ccccc2n1Cc1ccc(Cl)c([N+](=O)[O-])c1,,CS(C)=O,,,,val
US20130096113A1,Cn1cc(-c2nccnc2Cl)cn1.O>>Cn1cc(-c2ncc[nH]c2=O)cn1,,CS(C)=O,,[K+].[OH-],,val
US20160096827A1,C[C@H]1CN(c2ccc([N+](=O)[O-])cc2)CCN1C(=O)OC(C)(C)C>>C[C@H]1CN(c2ccc([N+](=O)[O-])cc2)CCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160016948A1,C=CC1(OC)CCN(C(=O)OC(C)(C)C)CC1.OO>>COC1(CCO)CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,[Na+].[OH-],,val
US05882628,CC(=O)Nc1c(I)c(COC(C)=O)c(I)c(C(=O)NCC(COC(C)=O)OC(C)=O)c1I.OCC(O)CBr>>CC(=O)N(CC(O)CO)c1c(I)c(CO)c(I)c(C(=O)NCC(O)CO)c1I,,CO,O,Cl,[Na+].[OH-],val
US20130029962A1,Cc1nc(CO[Si](C)(C)C(C)(C)C)ccc1NC(=O)NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1>>Cc1nc(CO)ccc1NC(=O)NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1,,C1CCOC1,,Cl,,val
US20080090825A1,CC(C)C(O)(C(=O)OCc1ccccc1)C(C)C(=O)OCc1ccccc1>>CC(C)C(O)(C(=O)O)C(C)C(=O)O,[Pd],C1CCOC1,,,,val
US04259352,CC(O)C(=O)O.O=C(O)Cc1ccc(NCCC2CCCCC2)cc1>>CC(OC(=O)Cc1ccc(NCCC2CCCCC2)cc1)C(=O)O,,Cc1ccccc1,,Cc1ccccc1S(=O)(=O)O,,val
US04039544,CC(C)(C)O.CCCOc1ccc(S)cc1C(N)=O>>CCCOc1ccc(SC(C)(C)C)cc1C(N)=O,,O,,O=S(=O)(O)O,,val
US20110172187A1,CSCCc1cccc([N+](=O)[O-])c1>>CSCCc1cccc(N)c1,[Fe],CO,,Cl,,val
US20110003801A1,Cn1c(NCc2ccc(F)c(C(F)(F)F)c2)nc2ccccc21.O=S(=O)(Cl)c1ccccc1>>Cn1c(N(Cc2ccc(F)c(C(F)(F)F)c2)S(=O)(=O)c2ccccc2)nc2ccccc21,,CCOC(C)=O,c1ccncc1,,,val
US07375227B2,CCOC(=O)C1(Cc2ccccc2)CCN(CCNC(=O)OCc2ccccc2)CC1>>CCOC(=O)C1(Cc2ccccc2)CCN(CCN)CC1,[Pd],CO,,,,val
US20090221600A1,CS(=O)(=O)Cl.CSc1ncc2cc(-c3ccccc3C)c(=O)n([C@H]3CCNC3)c2n1>>CSc1ncc2cc(-c3ccccc3C)c(=O)n([C@H]3CCN(S(C)(=O)=O)C3)c2n1,,CCOC(C)=O,c1ccncc1,Cl,O=C([O-])O.[Na+],val
US20150336986A1,CNC.Cn1c(=O)c2c(-c3ccccc3)n([C@@H](COS(C)(=O)=O)CSC(c3ccccc3)(c3ccccc3)c3ccccc3)cc2n(C)c1=O>>CN(C)C[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)n1cc2c(c1-c1ccccc1)c(=O)n(C)c(=O)n2C,,CCOC(C)=O,CN(C)C=O,,,val
US20030027743A1,CCOC(=O)C(=O)C(C)C.NNc1ccccc1>>CCOC(=NNc1ccccc1)C(=O)C(C)C,,Cc1ccccc1,,,,val
US20050113379A1,Cc1c(Br)cnc(N)c1C.O=S(=O)(O)O>>Cc1c(Br)cnc(O)c1C,,O,O=S(=O)(O)O,O=N[O-].[Na+],,val
US20070167443A1,COC(=O)C(=CNc1cccc(C)n1)C(=O)c1ccc(C)c(C)c1>>Cc1ccc2c(=O)c(C(=O)c3ccc(C)c(C)c3)c[nH]c2n1,,c1ccc(Oc2ccccc2)cc1,,,,val
US20100174065A1,IC(I)I.Nc1ccc2c(c1)CCCNC2=O>>O=C1NCCCc2cc(I)ccc21,,C1CCOC1,,CC(C)(C)ON=O,,val
US20060194849A1,COc1cc(C)c(Cl)cn1.O=C1CCC(=O)N1Br>>COc1ncc(Cl)c(C)c1Br,,CN(C)C=O,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US04462943,CCOC(=O)C(=O)CCc1ccccc1.C[C@H](N)C(=O)N1C[C@@H](Sc2ccccc2)C[C@H]1C(=O)O>>CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1C[C@@H](Sc2ccccc2)C[C@H]1C(=O)O,,CCO,O,[BH3-]C#N.[Na+],,val
US20070105904A1,C#Cc1cccnc1N.CCCCOCc1ccc(CC(Cl)=NO)cc1>>CCCCOCc1ccc(Cc2cc(-c3cccnc3N)on2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20120065212A1,Clc1ccc(Cl)nn1.OCC1CC1>>Clc1ccc(OCC2CC2)nn1,,CS(C)=O,,[H-].[Na+],,val
US20050054633A1,CN1C(=O)[C@@H](NC(=O)C(C)(F)C(=O)NCCC(F)(F)C(F)(F)F)c2ccccc2-c2ccccc21>>CN1C(=O)[C@@H](NC(=O)[C@](C)(F)C(=O)NCCC(F)(F)C(F)(F)F)c2ccccc2-c2ccccc21,,CC(C)O,,CCCCCCC,,val
US20020132810A1,CC(C)(F)CCC(CC(O)C(Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN.N#CBr>>CC(C)(F)CCC(CC(O)C(Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)c1nnc(N)o1,,C1COCCO1,O,O=C([O-])O.[K+],,val
US05189045,C=CC(=O)OCC.CCC(=O)N(C)C1CCNCC1>>CCOC(=O)CCN1CCC(N(C)C(=O)CC)CC1,,CCO,,,,val
US20100168430A1,COCCO.Nc1ccc2c(O)cccc2c1>>COCCOc1cccc2cc(N)ccc12,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040152690A1,CC(C)=O.NCc1ccc(-c2cc(C(F)(F)F)cc3nc(N4CCN(c5ncccc5C(F)(F)F)CC4)[nH]c23)cc1>>CC(C)NCc1ccc(-c2cc(C(F)(F)F)cc3nc(N4CCN(c5ncccc5C(F)(F)F)CC4)[nH]c23)cc1,CC(=O)O,ClC(Cl)Cl,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090029905A1,Cn1ccc(NC(=O)c2cc(O)cc(OC3CCOCC3)c2)n1.O=C(c1cnc(Cl)cn1)N1CCC1>>Cn1ccc(NC(=O)c2cc(Oc3cnc(C(=O)N4CCC4)cn3)cc(OC3CCOCC3)c2)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130172342A1,CCOC(=O)COc1ccc(NC(=O)CC2CCCCN2)c([N+](=O)[O-])c1>>CCOC(=O)COc1ccc(NC(=O)CC2CCCCN2)c(N)c1,[Pd],CCO,,,,val
US20080085890A1,CO[C@@H]1CCN(C(=O)[O-])C1C(C)(C)C.O=[N+]([O-])c1ccc(CBr)cc1>>COC1CCN(Cc2ccc([N+](=O)[O-])cc2)C1,,Cl,,CCOCC,,val
US20110257151A1,COC(=O)c1ccc2c(c1)CC(C)(C)C(c1ccccc1NC(=O)c1ccccn1)N2>>CC1(C)Cc2cc(C(=O)O)ccc2NC1c1ccccc1NC(=O)c1ccccn1,,C1CCOC1,,[Na+].[OH-],,val
US20120208827A1,CC(C)(C)OC(=O)N1CC[C@@H](CNc2cc(F)ccc2[N+](=O)[O-])C1.Cl>>Cl.O=[N+]([O-])c1ccc(F)cc1NC[C@@H]1CCNC1,,CO,,C1COCCO1,,val
US20100249165A1,CCOC(=O)NC(=O)/C(C#N)=C\c1ccccc1>>COC(=O)NC(=O)/C(C#N)=C\c1ccccc1,,CO,,,,val
US20110218192A1,C[Si](C)(C)N=C=N[Si](C)(C)C.O=C1c2cc(Br)ccc2OC2(CCCOC2)C1F>>N#C/N=C1/c2cc(Br)ccc2OC2(CCCOC2)C1F,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20110098324A1,CCOC(=O)CN=C=O.NCC(=O)O.O=C(NC1CCCCC1)c1cn(C2CCCCC2)c(=O)cc1O>>O=C(O)CNC(=O)c1c(O)c(C(=O)NC2CCCCC2)cn(C2CCCCC2)c1=O,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20150094474A1,CC1(C)C(/C=C(\Cl)C(F)(F)F)C1C(=O)Cl.NCc1cccc(Oc2ccccc2)c1>>CC1(C)C(/C=C(\Cl)C(F)(F)F)C1C(=O)NCc1cccc(Oc2ccccc2)c1,,CCOC(C)=O,Cc1ccccc1,c1ccncc1,,val
US06713471B1,C=CC(=O)O.Fc1ccc2cc[nH]c2c1>>O=C(O)CCc1cc2ccc(F)cc2[nH]1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20150119373A1,C=C(C)[C@@H]1CC[C@]2(C(=O)Cl)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CC1(C)[C@H](N)C[C@@H]1C(=O)O>>C=C(C)[C@@H]1CC[C@]2(C(=O)N[C@@H]3C[C@H](C(=O)O)C3(C)C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,ClCCl,,CCN(CC)CC,,val
US04654350,Cn1cnc2c(Cl)nccc21.SCc1ccccc1Cl>>Cn1cnc2c(SCc3ccccc3Cl)nccc21,,CCO,,,,val
US20140206688A1,CC(C)(C)Sc1cc2c(Nc3ccc4scnc4c3)ncnc2cc1O.CC(C)I>>CC(C)Oc1cc2ncnc(Nc3ccc4scnc4c3)c2cc1SC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030125370A1,C1CNC[C@H](CNC2CC2)C1.Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CC(=O)O>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CC(=O)N1CCC[C@@H](CNC2CC2)C1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20160000929A1,CC(C)OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1.CCCCB(O)O>>CCCCB1O[C@H]2C[C@@H](O1)[C@H](CC[C@@H](O)CCc1ccccc1)[C@H]2C/C=C\CCCC(=O)OC(C)C,,ClCCl,,,,val
US20100035883A1,COC(=O)c1cccc2c1C(=O)C(c1nccn1Cc1ccccc1)C(c1ccccc1)N2.NN>>O=c1[nH]nc2c3c(cccc13)NC(c1ccccc1)C2c1nccn1Cc1ccccc1,,CO,,O,,val
US03957861,CC(=O)Cl.O=[N+]([O-])c1ccccc1-c1ccccc1>>CC(=O)c1ccc(-c2ccccc2[N+](=O)[O-])cc1,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20100298320A1,CC(C)(C)OC(=O)Nc1ccc(O)cc1.Nc1nccc(Cl)c1[N+](=O)[O-]>>CC(C)(C)OC(=O)Nc1ccc(Oc2ccnc(N)c2[N+](=O)[O-])cc1,,CCOC(C)=O,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US20090286974A1,Brc1cnc(Br)s1.CC1CNCC(C)N1>>CC1CN(c2ncc(Br)s2)CC(C)N1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100136136A1,CCCCC=O.CN(C)C=O.Cc1ccc(Br)cc1NC(=O)c1nc[nH]c1C(=O)Nc1nc2ccc(N3CCNCC3)cc2[nH]1>>CC(=O)O.CCCCCN1CCN(c2ccc3[nH]c(NC(=O)c4[nH]cnc4C(=O)Nc4cc(Br)ccc4C)nc3c2)CC1,,CN(C)C=O,,[Na],,val
US20080032982A1,CCOC(=O)[C@H](CCc1ccccc1)Oc1ccc(Br)cc1.OB(O)c1ccco1>>CCOC(=O)[C@H](CCc1ccccc1)Oc1ccc(-c2ccco2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US04465504,CCN(CC(F)(F)F)C(=O)COC(C)=O>>CCN(CC(F)(F)F)C(=O)CO,,CO,,[Na+].[OH-],,val
US20160046624A1,CC(C)c1ccccc1-c1cnc2c(c1C(O)c1ccc(Cl)cc1)c(=O)n(CCCO[Si](C)(C)C(C)(C)C)c(=O)n2C.O=CO>>CC(C)c1ccccc1-c1cnc2c(c1Cc1ccc(Cl)cc1)c(=O)n(CCCOC=O)c(=O)n2C,[Zn],,,,,val
US05043447,Cc1[nH]c(-c2ccccc2)nc1C(C)O.ClC(Cl)Cl.O=S(Cl)Cl>>Cc1[nH]c(-c2ccccc2)nc1C(C)Cl.Cl,,ClC(Cl)Cl,,,,val
US20100099681A1,Cc1ccccc1NN.N#CC=C(N)C(F)(F)F>>Cc1ccccc1-n1nc(C(F)(F)F)cc1N,,Cl,,[Na+].[OH-],,val
US20030187014A1,CCCN.Cc1nn(-c2ccccn2)c2nc3ccccc3c(Cl)c12>>CCCNc1c2ccccc2nc2c1c(C)nn2-c1ccccn1,,O,,,,val
US20130150342A1,CNC.O=C1C2CCC1CN(Cc1ccccc1)C2>>CN(C)C1C2CCC1CN(Cc1ccccc1)C2,,ClCCl,,,,val
US20020120146A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.FC(F)(CCC1CCNCC1)c1ccccc1>>CC(C)(C)OC(=O)N1CCC(CCC(F)(F)c2ccccc2)CC1,,ClCCl,,CCOC(C)=O,,val
US20100292208A1,O=S(Cl)Cl.OCc1cc2ncc(Oc3nc4ncccc4s3)cc2o1>>ClCc1cc2ncc(Oc3nc4ncccc4s3)cc2o1,,ClCCl,,,,val
US20100286171A1,O=C(Nc1cnc(CCOC2CCCCO2)cn1)[C@H](CC1CCOCC1)c1ccc(S(=O)(=O)C2CC2)c(C2CC2)c1>>O=C(Nc1cnc(CCO)cn1)[C@H](CC1CCOCC1)c1ccc(S(=O)(=O)C2CC2)c(C2CC2)c1,,C1CCOC1,,Cl,O,val
US20090176786A1,CI.Cc1cc(SC(F)(F)F)ccc1N(C)C(=O)NC(=O)c1c(F)cccc1F>>Cc1cc(SC(F)(F)F)ccc1N(C)C(=O)N(C)C(=O)c1c(F)cccc1F,,CN1CCCC1=O,O,[H-].[Na+],[Cl-].[NH4+],val
US20140031374A1,CS(=O)(=O)c1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2Cl)nc1.ClP(Cl)(Cl)(Cl)Cl>>CS(=O)(=O)c1ccc(C(Cl)=Nc2ccc(OC(F)(F)F)cc2Cl)nc1,,c1ccccc1,,,,val
US04345077,Clc1ccc(Cl)nn1.Nc1cccc(O)c1>>Nc1cccc(Oc2ccc(Cl)nn2)c1,,CS(C)=O,,[Na+].[OH-],,val
US20160185778A1,CC(C)(C)OC(=O)N1CCc2c(c(C3=CC(O)CC3)nn2COCC[Si](C)(C)C)C1>>CC(C)(C)OC(=O)N1CCc2c(c(C3CCC(O)C3)nn2COCC[Si](C)(C)C)C1,[Pd],CO,,,,val
US20140323475A1,CC(C)(C)/N=C/c1cc(Cl)ccc1F.CC(C)C(C)O>>CC(C)C(C)Oc1ccc(Cl)cc1/C=N/C(C)(C)C,,C1COCCO1,,[H-].[Na+],,val
US03944672,BrBr.COC(=O)c1sc2ccccc2c1-c1ccccc1>>COC(=O)c1sc2ccc(Br)cc2c1-c1ccccc1,,CC(=O)O,,O=S([O-])O.[Na+],,val
US04317674,C#CCOC(=O)Nc1cccc(OC(=O)Cl)c1.Cc1ccc(NCC(C)C)cc1>>C#CCOC(=O)Nc1cccc(OC(=O)N(CC(C)C)c2ccc(C)cc2)c1,,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090291945A1,CC[C@@H](CNc1ccc(OCC(=O)OCc2ccccc2)cc1OC)NC(=O)[C@H](CC(C)(C)F)N[C@@H](c1ccc(Br)cc1)C(F)(F)F>>CC[C@@H](CNc1ccc(OCC(=O)O)cc1OC)NC(=O)[C@H](CC(C)(C)F)N[C@@H](c1ccccc1)C(F)(F)F,[Pd],C1CCOC1,,,,val
US04533655,CCN(C(=O)OC(C)(C)C)[C@H](C)C(=O)NCCCc1ccccc1.N#N>>CCN[C@H](C)C(=O)NCCCc1ccccc1.N#N,,CCOC(C)=O,Cl,,,val
US20150175557A1,CC(C)(C)OC(=O)NCCc1cncc(Cl)c1.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)NCCc1cc(Cl)c[n+]([O-])c1,,ClCCl,,,,val
US20050043248A1,C1CO1.CCCCCC1CNC(C(=O)NC(C(C)C)C2OC(CCC)C(O)C(O)C2O)C1>>CCCCCC1CC(C(=O)NC(C(C)C)C2OC(CCC)C(O)C(O)C2O)N(CCO)C1,,CCOCC,CO,,,val
US20080096861A1,CC(C)(C)OC(=O)N1CCC(CCl)CC1.CC(C)(C)OC(=O)NCCCCO>>CC(C)(C)OC(=O)NCCCCCl,,ClC(Cl)(Cl)Cl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05519034,COCCBr.COc1cc2c(cc1OCc1ccccc1)C(C1(c3ccccc3Cl)CC1)NCC2>>COCCN1CCc2cc(OC)c(OCc3ccccc3)cc2C1C1(c2ccccc2Cl)CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060111375A1,CCC(O)c1cc(I)ccc1Oc1ccnc2cc(OC)c(OC)cc12>>CCC(=O)c1cc(I)ccc1Oc1ccnc2cc(OC)c(OC)cc12,,CS(C)=O,,O,,val
US20110142796A1,Nc1nccc(NCC2CC2)n1.O=C1CCC(=O)N1I>>Nc1ncc(I)c(NCC2CC2)n1,,CC(=O)O,,,,val
US06174881B1,NC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NC1.O=C(CCl)CCl>>OCc1cn2c(n1)CN=C(c1ccccc1)c1cc(Cl)ccc1-2,,C1COCCO1,,O=C([O-])O.[Na+],,val
US04298529,CCOC(=O)C(=NO)C(C)=O.OCCO>>CCOC(=O)C(=NO)C1(C)OCCO1,Cc1ccc(S(=O)(=O)O)cc1,c1ccccc1,,,,val
US20160222014A1,CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3ncc4cnn(S(=O)(=O)c5cccc6cccnc56)c4n3)cc2)CC1>>O=S(=O)(c1cccc2cccnc12)n1ncc2cnc(Nc3ccc(N4CCNCC4)cc3)nc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110130398A1,CC(C)(C)CC1NC(C(=O)OC(C)(C)C)C(c2cccc(Cl)c2F)C12C(=O)Nc1c2ccc(Cl)c1F.O=C(O)C(F)(F)F>>CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C12C(=O)Nc1c2ccc(Cl)c1F.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20140221344A1,CC1CCN(c2ccncc2[N+](=O)[O-])CC1NC(=O)OC(C)(C)C>>CC1CC(NC(=O)OC(C)(C)C)CN(c2ccncc2N)C1,[Pd],,,CCO,,val
US05962474,CCOC(=O)Cl.Nc1ccc2[nH]ccc2c1>>CCOC(=O)n1ccc2cc(N)ccc21,,C1CCOC1,Cl,CCN(CC)CC,,val
US20040220236A1,OC1(c2nc3ccccc3s2)CCC2(CC1)OCCO2>>O=C1CCC(O)(c2nc3ccccc3s2)CC1,,CC(=O)O,Cl,,,val
US20130029980A1,BrBr.CCOC(CO)Cc1ccc(Cl)cc1>>CCOC(CBr)Cc1ccc(Cl)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160075710A1,CC(N=[N+]=[N-])c1cc(=O)n(C(C)C)nc1-c1ccccc1>>CC(N)c1cc(=O)n(C(C)C)nc1-c1ccccc1,,O,,,,val
US20140364411A1,CN(C)[C@H]1C[C@@H](c2nnc3ccc(F)cn23)N(C)C1.N[C@H]1CC[C@@H](O)c2ccccc21>>CN(C)[C@H]1C[C@@H](c2nnc3ccc(O[C@@H]4CC[C@H](N)c5ccccc54)cn23)N(C)C1,,CN(C)C=O,,[H-].[Na+],,val
US20040048909A1,CCCCCN.O=[N+]([O-])c1ccccc1-c1ccc(CBr)cc1>>CCCCCNCc1ccc(-c2ccccc2[N+](=O)[O-])cc1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20040103487A1,CCCBr.O=[N+]([O-])c1c(Br)n[nH]c1Br>>CCCn1nc(Br)c([N+](=O)[O-])c1Br,,CN(C)C=O,,[H-].[Na+],,val
US20070010563A1,CCC(CC)(CO)CO.N#Cc1cc(C=O)ccc1F>>CCC1(CC)COC(c2ccc(F)c(C#N)c2)OC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US03980643,COc1ccc(C(=O)O)c(OC)c1OC.O=C(O)/C=C\C(=O)O.OCCN1CCCNCC1>>COc1ccc(C(=O)O)c(OC)c1OC.O=C(O)/C=C\C(=O)O.OCCN1CCCNCC1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20040186127A1,C1CC2CCC(C1)C21OCCO1.ClCCl.O=[O+][O-]>>O=C1C2CCC1CC1(C2)OCCO1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040009970A1,O=C1CNC(=O)c2ccc(F)cc2N1>>Fc1ccc2c(c1)NCCNC2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050143422A1,CCOC(=O)c1oc2cccc(CO)c2c1C.CI>>CCOC(=O)c1oc2cccc(COC)c2c1C,O=[Ag],ClC(Cl)Cl,,,,val
US20160244437A1,Cc1ccc(S(=O)(=O)N(C)C)cc1-c1cccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3c(=O)[nH][nH]c3c2)c1.Cl>>Cc1ccc(S(=O)(=O)N(C)C)cc1-c1cccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc3c(=O)[nH][nH]c3c2)c1.Cl,,C1COCCO1,,,,val
US20060173179A1,BrCc1ccccc1.O=[N+]([O-])c1nc(Cl)ccc1O>>O=[N+]([O-])c1nc(Cl)ccc1OCc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US05459260,C=CCOC(=O)C(=O)Cl.C=CCOC(=O)O[C@H](C)[C@H]1C(=O)N[C@@H]1[C@@H]1CCCC(CCO[Si](C)(C)C(C)(C)C)C1=O>>C=CCOC(=O)O[C@H](C)[C@H]1C(=O)N(C(=O)C(=O)OCC=C)[C@@H]1[C@@H]1CCCC(CCO[Si](C)(C)C(C)(C)C)C1=O,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20030100770A1,O=C(OCc1ccccc1)[C@H]1CC(F)(F)CN1C(=O)CCCCC(=O)N1CC(F)(F)C[C@@H]1C(=O)OCc1ccccc1>>O=C(O)[C@H]1CC(F)(F)CN1C(=O)CCCCC(=O)N1CC(F)(F)C[C@@H]1C(=O)O,[Pd],CCO,,,,val
US20130296551A1,CC[C@@H](NC(=O)N1CC(=O)NC[C@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(=O)O)c(N)c1>>CC[C@@H](NC(=O)N1CC(=O)NC[C@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(=O)O)c(N)c1,,CC(C)O,,Cl,,val
US20110301141A1,CNc1nc(Cl)ncc1Cl.COC(=O)c1ccc(N)c(OC(F)F)c1>>CNc1nc(Nc2ccc(C(=O)OC)cc2OC(F)F)ncc1Cl,,CCCCO,,C1COCCO1,Cl,val
US20010014689A1,BrBr.Fc1cccc2ccccc12>>Fc1ccc(Br)c2ccccc12,,ClC(Cl)(Cl)Cl,,Br,,val
US04450165,CNCc1ccccc1.O=C(CBr)c1ccco1>>CN(Cc1ccccc1)CC(O)c1ccco1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150353553A1,COC(=O)c1nc(N[C@H](CCCOS(C)(=O)=O)C2CCC2)c2c(n1)nc(-c1cccc(C)c1)n2Cc1ccc(C(F)(F)F)cc1>>COC(=O)c1nc(N2CCC[C@@H]2C2CCC2)c2c(n1)nc(-c1cccc(C)c1)n2Cc1ccc(C(F)(F)F)cc1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20090093456A1,Cl.N#CCc1ccsc1>>Cl.NCCc1ccsc1,,C1CCOC1,,CO,,val
US20150210682A1,CCOc1ccc(CCNC=CC(=O)OC)cc1OCC.O=C(Cl)CC(=O)Cl>>CCOc1ccc(CCN2C=C(C(=O)OC)C(=O)CC2=O)cc1OCC,,ClCCl,,,,val
US20140187553A1,CCO.COc1ccc(CNc2nnc(-c3ccc4c(c3)c(-c3cncc(Cl)n3)cn4S(=O)(=O)c3ccc(C)cc3)s2)cc1>>CCOc1cncc(-c2c[nH]c3ccc(-c4nnc(NCc5ccc(OC)cc5)s4)cc23)n1,,CCO,,C,C[O-].[Na+],val
US04994569,CC(C)(C)c1ccc(C2=NCC(O)C(c3ccccc3)O2)cc1.O=C=Nc1ccccc1>>CC(C)(C)c1ccc(C2=NCC(OC(=O)Nc3ccccc3)C(c3ccccc3)O2)cc1,,C1CCOC1,,,,val
US20120190672A1,O=C(NC1=N[C@@]2(c3cccc(F)c3F)CO[C@H](C(F)(F)F)[C@H]2CS1)c1ccccc1>>NC1=N[C@@]2(c3cccc(F)c3F)CO[C@H](C(F)(F)F)[C@H]2CS1,,CO,,C1CCC2=NCCCN2CC1,,val
US20100144714A1,CN1CCN(c2ccc(CN)cc2)CC1.COC(=O)C(CC(C)C)n1c(Cl)nc2ccccc2c1=O>>CC(C)CC1C(=O)N(Cc2ccc(N3CCN(C)CC3)cc2)c2nc3ccccc3c(=O)n21.Cl,,C1CCOC1,,,,val
US20150126734A1,CCN(CC)C(=O)Cl.O=C(O)Cc1ccccc1>>CCN(CC)C(=O)Cc1ccccc1,,O,,,,val
US20110189794A1,COC(=O)C1=CN2C(=NCC2(c2ccc(C)cc2)C(O)C(=O)O)C=C1>>COC(=O)C1=CN2C(=NCC2(CC(=O)O)c2ccc(C)cc2)C=C1,[Pd],O=CO,,,,val
US20040229872A1,CN(C)C1(Cc2ccccc2)CCC(=O)CC1.Nc1ccc2c(c1)CCC2>>CN(C)C1(Cc2ccccc2)CCC(Nc2ccc3c(c2)CCC3)CC1,,ClCCCl,,O=S(=O)([O-])[O-].[Na+].[Na+],,val
US05300687,CCOP(=O)(Cc1ccc(C(F)(F)F)cc1)OCC>>O=P(O)(O)Cc1ccc(C(F)(F)F)cc1,,CCO,Cl,,,val
US20100317850A1,CO[C@H]1C[C@@H](CO)[C@](N)(c2ccccc2F)C1.O=C(N=C=S)OCc1cccc2c1Cc1ccccc1-2>>CO[C@H]1C[C@@H](CO)[C@](NC(=S)NC(=O)OCC2c3ccccc3-c3ccccc32)(c2ccccc2F)C1,,ClCCl,,,,val
US20110142856A1,CCCN(CCC)CCCCNCc1ccc(C(=O)N(Cc2nccn2COCC[Si](C)(C)C)Cc2nccn2COCC[Si](C)(C)C)cc1>>CCCN(CCC)CCCCNCc1ccc(C(=O)N(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1,,CO,Cl,[Na+].[OH-],,val
US04830470,CCCCC[C@@H]1CC[C@@H](CCc2ccc(O)cc2)CC1.CC[C@H](C)CCCCCOc1ccc(C(=O)Cl)cc1>>CCCCC[C@@H]1CC[C@@H](CCc2ccc(OC(=O)c3ccc(OCCCCC[C@@H](C)CC)cc3)cc2)CC1,,Cc1ccccc1,c1ccncc1,,,val
US20140138627A1,Brc1ccc2[nH]c3ccccc3c2c1.Ic1ccccc1>>Brc1ccc2c(c1)c1ccccc1n2-c1ccccc1,[Cu],Clc1ccccc1Cl,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20040116699A1,COC(=O)C(Cc1ccc(Cl)cc1)NC(=O)C1Cc2ccccc2CN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1Cc2ccccc2CC1C(=O)NC(Cc1ccc(Cl)cc1)C(=O)O,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20050256140A1,C#CC1(N)CCCCC1.Cn1c(Br)nc(-c2ccccc2)c1-c1nc2c(N)ncnc2s1>>Cn1c(C#CC2(N)CCCCC2)nc(-c2ccccc2)c1-c1nc2c(N)ncnc2s1,[Cu]I,CN(C)C=O,,CCN(CC)CC,,val
US20060004017A1,COc1cc2c(Cl)ncnc2cc1OCCCN1CCCC1.Cc1cc2cc(O)ccc2[nH]1>>COc1cc2c(Oc3ccc4[nH]c(C)cc4c3)ncnc2cc1OCCCN1CCCC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080085898A1,N[C@@H]1CCCc2ccccc21.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(N[C@@H]1CCCc2ccccc21)C(F)(F)F,,ClCCl,,,,val
US20020161237A1,COC(=O)/C(=C/c1sc(C(C)C)nc1C)NC(=O)c1ccc(C(=O)NCc2cccc(O)c2)cc1Cl>>Cc1nc(C(C)C)sc1/C=C(\NC(=O)c1ccc(C(=O)NCc2cccc(O)c2)cc1Cl)C(=O)O,,C1CCOC1,CO,[Na+].[OH-],,val
US05380837,CC(C)NCC(O)c1ccc(O)c(O)c1>>CC(C)NCC(O)c1ccc(O)c(O)c1,,O,,Cl,,val
US20090004209A1,NC1CCC(=O)NC1=O.O=C(O)c1cccc(OCc2ccccc2)c1C(=O)O>>O=C1CCC(N2C(=O)c3cccc(OCc4ccccc4)c3C2=O)C(=O)N1,,c1ccncc1,,Cl,,val
US20070219210A1,CCc1ccc(C(=O)N(C)OC)nc1.[Li]C>>CCc1ccc(C(C)=O)nc1,,C1CCOC1,,CCOC(C)=O,O=C([O-])O.[Na+],val
US06211378B1,CC1(C)CC(O)CC(C)(C)N1O.Cc1ccc(C)cc1>>Cc1ccc(CON2C(C)(C)CC(O)CC2(C)C)cc1,,Clc1ccccc1,,,,val
US20080269192A1,C[C@@H](CNC(=O)OC(C)(C)C)Nc1c([N+](=O)[O-])cnc2ccccc12>>C[C@@H](CNC(=O)OC(C)(C)C)Nc1c(N)cnc2ccccc12,[Pt],CC#N,,,,val
US20040142955A1,Cc1cccc2c1C(CO)CCC2>>Cc1cccc2c1C(C=O)CCC2,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20060223801A1,CONC(=O)c1cc(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)nc(OCCN)n1.CS(=O)(=O)Cl>>CONC(=O)c1cc(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)nc(OCCNS(C)(=O)=O)n1,,CN(C)C=O,,,,val
US05891871,COC(=O)Cc1ccc2c(c1)OCO2.O=C(Cl)c1ccc(F)cc1>>COC(=O)Cc1cc2c(cc1C(=O)c1ccc(F)cc1)OCO2,,ClCCl,,Cl[Sn](Cl)(Cl)Cl,,val
US20160096827A1,CC(C)(C)OC(=O)N1CCC(O)C(F)C1.N#Cc1cc(Br)cc(F)c1O>>CC(C)(C)OC(=O)N1CC[C@H](Oc2c(F)cc(Br)cc2C#N)[C@H](F)C1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120028961A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(NCc1ccc(O)cc1)C(F)(F)F>>CC(C)(C)OC(=O)NCc1ccc(O)cc1,,CO,ClCCl,Cl,[Na+].[OH-],val
US20090088425A1,COc1cccc(NN)c1>>COc1cccc(NN)c1,,[Na+],[OH-],Cl,,val
US20150284387A1,CCOC(=O)CC(O)(C(=O)OCC)c1c(C)nn(Cc2ccc(Oc3ccccc3)cc2)c1N>>CCOC(=O)c1cc(O)nc2c1c(C)nn2Cc1ccc(Oc2ccccc2)cc1,,CC(=O)O,,,,val
US04614833,Br.O=C(c1ccc(F)cc1)c1ccc(Cl)nc1>>O=C(c1ccc(F)cc1)c1ccc(Br)nc1,,O,,[Na+].[OH-],,val
US20040110945A1,COC(=O)Cc1ccc(N)c(Cl)c1.O=C(O)c1cn(Cc2ccccc2)c2ccccc12>>COC(=O)Cc1ccc(NC(=O)c2cn(Cc3ccccc3)c3ccccc23)c(Cl)c1,,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20060199817A1,CC(C)(C)[Si](C)(C)Cl.OCc1ccc(Cl)cc1F>>CC(C)(C)[Si](C)(C)OCc1ccc(Cl)cc1F,,C1CCOC1,,c1c[nH]cn1,,val
US20090181943A1,COC(=O)C(c1ccccc1)C1CCN(C(=O)OCc2ccccc2)CC1>>COC(=O)C(c1ccccc1)C1CCNCC1,,CCO,,CO,,val
US20050070592A1,COC(=O)COc1ccc(-c2ccc3c(c2)c(Cc2ccccc2)c(-c2ccccc2)n3C)cc1>>Cn1c(-c2ccccc2)c(Cc2ccccc2)c2cc(-c3ccc(OCC(=O)O)cc3)ccc21,,C1CCOC1,CO,[K+].[OH-],,val
US20030215701A1,Nc1cccc([N+](=O)[O-])c1N.O=C(C(=O)c1ccccc1)c1ccccc1>>O=[N+]([O-])c1cccc2nc(-c3ccccc3)c(-c3ccccc3)nc12,,CC(=O)O,CO,,,val
US20100004447A1,Cc1nc2c(O)cccn2c(=O)c1CCO.O=S(Cl)Cl>>Cc1nc2c(O)cccn2c(=O)c1CCCl,,CN(C)C=O,,,,val
US04585789,BrCc1ccccc1.OCCCC=Cc1ccccc1>>C(=Cc1ccccc1)CCCOCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20090312347A1,CI.c1cncc(-c2noc(-c3ccc[nH]3)n2)c1>>Cn1cccc1-c1nc(-c2cccnc2)no1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20130053359A1,N#Cc1cc(F)c(N)cc1F.O=S(=O)(O)O.[OH-]>>Nc1cc(F)c(C(=O)O)cc1F,,C1COCCO1,,O,,val
US05256784,O=Cc1ccc(F)cc1.OCCOCCN1CCNCC1>>O=Cc1ccc(N2CCN(CCOCCO)CC2)cc1,,O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20040152775A1,O=C1c2ccccc2C(=O)N1C[C@H]1CO1.Sc1nc2ccccc2s1>>O=C1c2ccccc2C(=O)N1C[C@H](O)CSc1nc2ccccc2s1,,CCO,,,,val
US20110201593A1,NC1CCC(F)(F)CC1.O=[N+]([O-])c1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1Cl>>O=[N+]([O-])c1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1NC1CCC(F)(F)CC1,,CC(C)O,,CCN(C(C)C)C(C)C,Cl,val
US20090163488A1,CCc1nc(C(=O)O)c(C(F)(F)F)o1.Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)c1>>CCc1nc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)c(C(F)(F)F)o1,CN(C)C=O,CC(=O)N(C)C,,C1CCOC1,O=C(Cl)C(=O)Cl,val
US20130210844A1,CC(C)C(=O)NCc1cnc(C(F)F)c(C(=O)O)c1.Nc1cccc2c(Oc3ccc(F)c(C(F)(F)F)c3)ccnc12>>CC(C)C(=O)NCc1cnc(C(F)F)c(C(=O)Nc2cccc3c(Oc4ccc(F)c(C(F)(F)F)c4)ccnc23)c1,CN(C)C=O,ClCCl,,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20130264554A1,Cc1ccc(-c2cn(-c3ccc4c(c3)c3ccccc3n4C)c(I)n2)s1.Cc1ccc(B2OC(C)(C)C(C)(C)O2)s1>>Cc1ccc(-c2cn(-c3ccc4c(c3)c3ccccc3n4C)c(-c3ccc(C)s3)n2)s1,,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20150282482A1,COC(=O)CS.O=Cc1cc(Cl)ccc1F>>COC(=O)c1cc2cc(Cl)ccc2s1,,COC(C)(C)C,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05057524,CN(C)C(=O)CCCCl.O=C(O)C(=O)O.OC(c1ccc(F)cc1)(c1ccc(F)cc1)C1CCNCC1>>CN(C)C(=O)CCCN1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1.O=C(O)C(=O)O,,CN(C)C=O,O,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US04535172,CCN(CC)c1ccc(C(=O)c2ccccc2C(=O)O)c(C)c1.O=C/C(Cl)=C(/Cl)C(=O)O.c1ccncc1>>CCN(CC)c1ccc(C2(OC3OC(=O)C(Cl)=C3Cl)OC(=O)c3ccccc32)c(C)c1,,ClCCCl,,O=S(Cl)Cl,,val
US20030105078A1,CC(=O)OCCBr.Cc1cc(O)cc(C)c1Cc1ccc(OCc2ccccc2)c(S(=O)(=O)c2ccc(F)cc2)c1>>CCOC(=O)COc1cc(C)c(Cc2ccc(OCc3ccccc3)c(S(=O)(=O)c3ccc(F)cc3)c2)c(C)c1,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20070254917A1,CI.Cc1cc(-c2cccc(C#N)c2)c(O)c2c1NC(C)(C)CC2C>>COc1c(-c2cccc(C#N)c2)cc(C)c2c1C(C)CC(C)(C)N2,,CN(C)C=O,O,[Cs+].[F-],,val
US05559230,COC(=O)c1ccc(C(=O)N2CCCc3ccccc32)cc1>>O=C(O)c1ccc(C(=O)N2CCCc3ccccc32)cc1,,CO,,[Na+].[OH-],,val
US04207104,COS(=O)(=O)OC.O=[N+]([O-])O.Oc1cccnc1O>>COc1cc([N+](=O)[O-])c[nH]c1=O,,O=S(=O)(O)O,,[Na+].[OH-],,val
US03949085,O=[N+]([O-])c1ccc(CI)cc1.O=c1c(-c2ccccc2)coc2cc(O)ccc12>>O=c1c(-c2ccccc2)coc2cc(OCc3ccc([N+](=O)[O-])cc3)ccc12,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130317001A1,CS(N)(=O)=O.O=C(O)c1cc(Cl)c(OCC2CCCC(F)(F)C2)cc1F>>CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCC(F)(F)C2)cc1F,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130338173A1,C=O.CC1(C)O[C@@H]2[C@H](O1)[C@@H](CNCCCCc1nc3cc(C(F)(F)F)c(Cl)cc3n1COCC[Si](C)(C)C)C[C@H]2n1ccc2c(NC3CC3)ncnc21>>CN(CCCCc1nc2cc(C(F)(F)F)c(Cl)cc2n1COCC[Si](C)(C)C)C[C@H]1C[C@@H](n2ccc3c(NC4CC4)ncnc32)[C@@H]2OC(C)(C)O[C@H]12,,C1CCOC1,CO,[BH3-]C#N.[Na+],,val
US20070155721A1,CCOC(=O)CCl.Oc1cccc(F)c1>>CCOC(=O)COc1cccc(F)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20030158179A1,CCOC(=O)c1ccc2c(Cl)cc(C)nc2c1>>Cc1cc(Cl)c2ccc(CO)cc2n1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US06248740B1,CC(C)(C)[Si](OCCO)(c1ccccc1)c1ccccc1.Clc1ccc2ncnn2n1>>OCCOc1ccc2ncnn2n1,,CN(C)C=O,,[H-].[Na+],,val
US20080280875A1,C1CNC1.COC(=O)c1cnc(Oc2cc(C(=O)Nc3ccn(C)n3)cc3c2CC(C)(C)O3)cn1>>Cn1ccc(NC(=O)c2cc(Oc3cnc(C(=O)N4CCC4)cn3)c3c(c2)OC(C)(C)C3)n1,,CC(=O)O,,,,val
US20060148858A1,CCCC(=O)Cl.COC(=O)Cc1cccc(OC)c1OCCCc1cn(-c2ccc(N)cn2)nc1C(C)C>>CCCC(=O)Nc1ccc(-n2cc(CCCOc3c(CC(=O)O)cccc3OC)c(C(C)C)n2)nc1,,O,,CN(C)C=O,,val
US04242519,CI.COC(=O)C(SC)c1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1>>COC(=O)C(C)(SC)c1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20130079377A1,Cc1cccc(-c2nc(C(F)(F)F)ccc2C#N)c1>>Cc1cccc(-c2nc(C(F)(F)F)ccc2CN)c1,,N,,,,val
US04626602,C#CC(O)CCC.CCC1(C)CCCC(C)C1=O>>CCCC(O)C#CC1(O)C(C)CCCC1(C)CC,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20110053940A1,COC(=O)C=Cc1cc(CN(C(=O)OC(C)(C)C)C2CC2)c2ncccc2c1>>COC(=O)CCc1cc(CN(C(=O)OC(C)(C)C)C2CC2)c2ncccc2c1,[Pd],CCOC(C)=O,,,,val
US20160244815A1,C1CCOC1.CCCC[Sn](CCCC)(CCCC)c1ccc[c-]1C=O.CCO.[Fe+2].c1cc[cH-]c1>>CCCC[Sn](CCCC)(CCCC)c1ccc[c-]1COCCCO.[Fe+2].c1cc[cH-]c1,,CCO,CCOC(C)=O,O,[BH4-].[Na+],val
US20060189593A1,CN1C(=O)NC(=O)C12Cc1ccccc1C2.O=[N+]([O-])O>>CN1C(=O)NC(=O)C12Cc1ccc([N+](=O)[O-])cc1C2,,O,,,,val
US20160075663A1,N#Cc1ccc([N+](=O)[O-])c(F)c1.Nc1ccc(F)cc1>>N#Cc1ccc([N+](=O)[O-])c(Nc2ccc(F)cc2)c1,,Cl,,CCN(CC)CC,,val
US20130303492A1,NC(=O)c1c(Nc2cccc(Cl)c2)n[nH]c1N.O=Cc1ccc(O)cc1>>NC(=O)c1c(Nc2cccc(Cl)c2)n[nH]c1N=Cc1ccc(O)cc1,,CCO,,C1CCNCC1,,val
US20090042841A1,Cc1cccc(C#CC=C2CCNCC2)n1.O=C(O)c1ccccc1[N+](=O)[O-]>>Cc1cccc(C#CC=C2CCN(C(=O)c3ccccc3[N+](=O)[O-])CC2)n1,,CN(C)C=O,ClCCl,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20060264428A1,CCOC(=O)C1(C)CN(C(=O)OCc2ccccc2)CC1O.CI>>CCOC(=O)C1(C)CN(C(=O)OCc2ccccc2)CC1OC,,CN(C)C=O,,[H-].[Na+],,val
US20050256158A1,CC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2ccc(F)c(O)c2)c2ccccc21.COC(=O)C(C)(C)CCBr>>COC(=O)C(C)(C)CCOc1cc(C(=O)N2c3ccccc3[C@H](N(C(C)=O)c3ccc(Cl)cc3)C[C@@H]2C)ccc1F,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100105700A1,C[C@]12CCC(=O)N(C3CC3)C1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(OS(=O)(=O)C(F)(F)F)=CC[C@@H]12.OB(O)c1ccncc1>>C[C@]12CCC(=O)N(C3CC3)C1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3ccncc3)=CC[C@@H]12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,,,val
US06211215B1,Nc1ccc(Br)cn1.O=C(CCl)CCl>>ClCc1cn2cc(Br)ccc2n1,,COCCOC,,,,val
US20100137305A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.C[C@@H]1CC[C@@H](C)N1>>C[C@@H]1CC[C@@H](C)N1C1CCN(C(=O)OC(C)(C)C)CC1,,OCC(F)(F)F,,[BH3-]C#N.[Na+],,val
US20140135318A1,CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)NS(=O)(=O)c3ccc4ccccc4c3)cc2C(=O)N2Cc3ccccc3C[C@H]2COCCOCc2ccccc2)c(C)c1Cl>>CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)NS(=O)(=O)c3ccc4ccccc4c3)cc2C(=O)N2Cc3ccccc3C[C@H]2COCCO)c(C)c1Cl,,ClCCl,,ClB(Cl)Cl,,val
US20090275592A1,C#CCC[C@H](Cc1ccc(C(F)(F)F)nc1)NC(=O)OC(C)(C)C.[N-]=[N+]=Nc1ccc2[nH]ncc2c1>>CC(C)(C)OC(=O)N[C@H](CCc1cn(-c2ccc3[nH]ncc3c2)nn1)Cc1ccc(C(F)(F)F)nc1,,CC(C)(C)O,O,O=C(CO)O[CH][C@@H](O)CO,C[O-].[Na+],val
US05562859,CCCCCCCC(O)[SiH](C)C.CCCCCCCCc1ncc(-c2ccc(O)cc2)nc1F>>CCCCCCCCc1ncc(-c2ccc(OCCCC(CCCC)[SiH](C)C)cc2)nc1F,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150320044A1,C=CC(=O)Cl.NC(c1cccc(C(F)(F)F)c1)C(F)(F)F>>C=CC(=O)NC(c1cccc(C(F)(F)F)c1)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US04060636,CC(=O)NC(=S)Nc1cc(C(=O)c2ccccc2)ccc1N.COC(=O)N=C=S>>COC(=O)NC(=S)Nc1ccc(C(=O)c2ccccc2)cc1NC(=S)NC(C)=O,,CC(C)=O,,,,val
US06201004B1,CCOC(=O)c1sc2ccc(O)c(C=O)c2c1Cl.Cc1ccc(S(=O)(=O)OC[C@H]2CO2)cc1>>CCOC(=O)c1sc2ccc(OC[C@H]3CO3)c(C=O)c2c1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060258742A1,NC(=O)Oc1ccccc1.NCc1ccc(OC(F)(F)F)cc1>>NC(=O)NCc1ccc(OC(F)(F)F)cc1,,CS(C)=O,,CCOC(C)=O,O,val
US20070259910A1,CCOC(=O)c1[nH]c2ccccc2c1Br.O=[N+]([O-])c1ccc(B(O)O)cc1>>CCOC(=O)c1[nH]c2ccccc2c1-c1ccc([N+](=O)[O-])cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,[Cl-].[Na+],O=C([O-])[O-].[Li+],val
US05578592,COc1ccc(COC(=O)C2=C(OS(=O)(=O)C(F)(F)F)C[S@](=O)[C@@H]3[C@H](NC(=O)Cc4ccccc4)C(=O)N23)cc1.O=C(OO)c1cccc(Cl)c1>>COc1ccc(COC(=O)C2=C(OS(=O)(=O)C(F)(F)F)CS(=O)(=O)[C@@H]3[C@H](NC(=O)Cc4ccccc4)C(=O)N23)cc1,,ClC(Cl)Cl,,,,val
US20100278833A1,COC(=O)c1sc(-n2cnc3cnc(Cl)cc32)cc1OCc1ccccc1C(F)(F)F.N>>NC(=O)c1sc(-n2cnc3cnc(Cl)cc32)cc1OCc1ccccc1C(F)(F)F,,CO,,,,val
US05985873,CC1CCC(c2cccc(NC(=O)N3CCC(=O)CC3)c2)(N2CCN(c3ccccc3)CC2)CC1.CN>>CNC1CCN(C(=O)Nc2cccc(C3(N4CCN(c5ccccc5)CC4)CCC(C)CC3)c2)CC1,,C1CCOC1,CO,Cl,,val
US06255333B1,C=C[Sn](CCCC)(CCCC)CCCC.Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(C)c1I>>C=Cc1c(C)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US04816581,C[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1C(=O)N[C@@H]1Sc1ccc(Cl)cc1>>CC(O)C1C(=O)NC1Sc1ccc(Cl)cc1,,C1CCOC1,CO,,,val
US20130085151A1,C[C@@H](c1cc2ccsc2nc1Cl)N1C(=O)c2ccccc2C1=O.OB(O)c1cccc(F)c1>>C[C@H](NC(=O)c1ccccc1C(=O)O)c1cc2ccsc2nc1-c1cccc(F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US05250700,COC(=O)N1NC(=O)CC1c1ccc(OC)c(OC2CCCC2)c1>>COc1ccc(C2CC(=O)NN2C(=O)O)cc1OC1CCCC1,,CO,,[Na+].[OH-],,val
US20080139558A1,O=C(O)/C=C/c1ccco1>>O=C(O)CCc1ccco1,[Pd],CC(=O)O,,,,val
US20140249129A1,CC(C)(C)OC(=O)N(CC1=C(Nc2cccc(C(F)(F)F)c2)CCCC1=O)c1ccc(C#N)cc1Cl.Cl>>Cl.N#Cc1ccc(C(N)C2=C(Nc3cccc(C(F)(F)F)c3)CCCC2=O)c(Cl)c1,,C1COCCO1,,,,val
US20100249192A1,N#Cc1ccc(Oc2cc(Br)ccc2Cl)cc1.NO>>NC(=NO)c1ccc(Oc2cc(Br)ccc2Cl)cc1,,CCO,,CCN(CC)CC,Cl,val
US20140094465A1,COc1ccc(-c2ccc(-c3ccc(C(=O)O)cc3)s2)c(F)c1>>O=C(O)c1ccc(-c2ccc(-c3ccc(O)cc3F)s2)cc1,,ClCCl,,BrB(Br)Br,,val
US20110160255A1,Cn1ncc(Cl)c1-c1nc(C(=O)O)cs1.N[C@@H](Cc1cccc(F)c1)CN1C(=O)c2ccccc2C1=O>>Cn1ncc(Cl)c1-c1nc(C(=O)N[C@@H](Cc2cccc(F)c2)CN2C(=O)c3ccccc3C2=O)cs1,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20050148623A1,CC(C)(C)OC(=O)[C@@H](NCCNC(=O)OCc1ccccc1)C(C)(C)C>>CC(C)(C)[C@H](NCCNC(=O)OCc1ccccc1)C(=O)O,,C1COCCO1,Cl,,,val
US20090318405A1,N#CCC(C1CCCC1)n1cc(-c2ccnc(Nc3ccc([N+](=O)[O-])cc3)n2)cn1>>N#CCC(C1CCCC1)n1cc(-c2ccnc(Nc3ccc(N)cc3)n2)cn1,[Pd],CO,,,,val
US20090163586A1,Nc1ccc(Oc2ccccc2)cc1.O=C=NS(=O)(=O)Cl>>O=C1Nc2ccc(Oc3ccccc3)cc2S(=O)(=O)N1,,C[N+](=O)[O-],,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20090181942A1,CCOC(=O)[C@H](CC(C)C)NC(=O)C[C@H]1O[C@H](c2cccc(OC)c2Cl)c2cc(Cl)ccc2-n2c1nnc2C(F)(F)F.O>>COc1cccc([C@H]2O[C@H](CC(=O)O)c3nnc(C(F)(F)F)n3-c3ccc(Cl)cc32)c1Cl,,C1COCCO1,,CCOC(C)=O,Cl,val
US20090227566A1,COCOc1cc(C(C)N)ccc1C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1>>CC(N)c1ccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(Cl)cn2)c(O)c1,,ClCCl,,O,O=C(O)C(F)(F)F,val
US05219859,Cn1cc(C2(CN)CCCC2)c2ccccc21.O=C(Cl)c1ccccc1>>Cn1cc(C2(CNC(=O)c3ccccc3)CCCC2)c2ccccc21,,CCOCC,CCOCC,CCN(CC)CC,,val
US20070185126A1,COc1ccc(S(=O)(=O)N2C(=O)C(c3cccnc3OC)(N3C[C@H](O)C[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1>>COc1ccc(S(=O)(=O)N2C(=O)C(c3ccc[nH]c3=O)(N3C[C@H](O)C[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1,,CC(=O)O,CCOC(C)=O,[I-].[Na+],,val
US20100113422A1,CC(C)(C)OC(=O)N1CCc2nc(Cc3ccccc3)[nH]c(=O)c2CC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCc2nc(Cc3ccccc3)nc(OS(=O)(=O)C(F)(F)F)c2CC1,,ClCCl,,c1ccncc1,,val
US20150218169A1,COC(=O)C1CCN(c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cccc(F)c23)C(C)C1>>CC1CC(C(=O)O)CCN1c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cccc(F)c12,,C1COCCO1,O,Cl,[Li+].[OH-],val
US20150291539A1,CCOC(=O)OCC.OCC(O)CNc1ccccc1>>O=C1OC(CO)CN1c1ccccc1,,ClCCl,,CO,C[O-].[Na+],val
US20120190677A1,CC1(C)CC(c2cccc(N3CCOCC3)c2)Nc2ccc(C(=O)NS(=O)(=O)C3CC3)cc21.CN(C)C=O>>CN(C(=O)c1ccc2c(c1)C(C)(C)CC(c1cccc(N3CCOCC3)c1)N2)S(=O)(=O)C1CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100152450A1,CC(C)(C)OC(=O)N1CC[C@H]1COc1cncc(-c2cccc(CCCNC(=O)OCc3ccccc3)c2)c1>>CC(C)(C)OC(=O)N1CC[C@H]1COc1cncc(-c2cccc(CCCN)c2)c1,[Pd],CO,,N#N,,val
US05440044,CCCCCCCCC(O)/C=C/c1cccc(Oc2cccc(C(=O)OC)c2)n1>>CCCCCCCCC(O)/C=C/c1cccc(Oc2cccc(C(=O)O)c2)n1,,CO,,[Na+].[OH-],,val
US20160090387A1,CCCn1cnc2c(Cl)nc(Cl)nc21.NCCc1ccccc1>>CCCn1cnc2c(NCCc3ccccc3)nc(Cl)nc21,,CCCCO,,CCN(CC)CC,,val
US20050107400A1,CCOC(OCC)(OCC)c1ccc2c(-c3ccnc(NC4CCCC4)n3)c(-c3ccc(F)cc3)nn2c1>>CCOC(=O)c1ccc2c(-c3ccnc(NC4CCCC4)n3)c(-c3ccc(F)cc3)nn2c1,,CC(C)=O,O,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20150368238A1,CCOC(=O)CBr.COC(OC)N(C)C.Nc1ccc(N2CCCC2c2cc(F)ccc2O[C@@H]2CCOC2)cn1>>CCOC(=O)c1cnc2ccc(N3CCCC3c3cc(F)ccc3O[C@@H]3CCOC3)cn12,,Cc1ccccc1,,CO,,val
US20040092739A1,Cc1ccc(N)c(C#N)c1.N#CNC(=N)N>>Cc1ccc2nc(N)nc(N)c2c1,,Cl,,O,,val
US20100143341A1,O=[N+]([O-])c1ccccc1F.OC1CCOC1>>O=[N+]([O-])c1ccccc1OC1CCOC1,,C1CCOC1,C1CCOC1,O,[H-].[Na+],val
US04992435,CC1(C)Oc2ccsc2C(N2CCCCC2=O)C1O.O=[N+]([O-])O>>CC1(C)Oc2cc([N+](=O)[O-])sc2C(N2CCCCC2=O)C1O,,CC(=O)O,,[Br-].[K+],,val
US20060258671A1,Nc1ccc(I)cc1.O=S(=O)(Cl)N1CCOCC1>>O=S(=O)(Nc1ccc(I)cc1)N1CCOCC1,,CC#N,,CCN(CC)CC,,val
US20050227983A1,Cc1ccc(N)cc1F.Clc1nc(Cl)nc(Cl)n1>>Cc1ccc(Nc2nc(Cl)nc(Cl)n2)cc1F,,CC(C)=O,,[Na+].[OH-],,val
US20100022484A1,COc1ccc(C(=O)CC(C)=O)cc1.Cc1cc(=O)c2cccc(C=O)c2o1>>COc1ccc(C(=O)C(=Cc2cccc3c(=O)cc(C)oc23)C(C)=O)cc1,,ClCCl,,C1CCNCC1,CC(=O)O,val
US20130079328A1,Cc1cc(B(O)O)ccn1.NCc1ccc(Cl)nc1>>Cc1cc(-c2ccc(CN)cn2)ccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20110184188A1,Cc1c(CCl)cccc1[N+](=O)[O-].NN>>Cc1c(CNN)cccc1[N+](=O)[O-],,CCO,,O,,val
US20020128269A1,COc1ccc(S(=O)(=O)N2CCN(C(=O)OC(C)(C)C)C[C@H]2C(=O)NN2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1OC>>COc1ccc(S(=O)(=O)N2CCNC[C@H]2C(=O)NN2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1OC,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140100217A1,C/C=C/CO.NCC(=O)O.O=C(O)C(F)(F)F>>C/C=C/COC(=O)CNC(=O)C(F)(F)F,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US06878704B2,Cc1ccc(Cl)nn1.O=C1CCC(=O)N1Cl>>ClCc1ccc(Cl)nn1,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20110015240A1,CC(=O)Nc1nc(CCc2ccc(CS)s2)cs1.CC(C)(C)OC(=O)NN.O=C(n1ccnc1)n1ccnc1>>CC(=O)Nc1nc(CCc2ccc(CSC(=O)NNC(=O)OC(C)(C)C)s2)cs1,,C1CCOC1,,,,val
US20050032817A1,CCC(NCCN(C)C)c1nc2oc(Br)cc2c(=O)n1Cc1ccccc1>>CCC(NCCN(C)C)c1nc2occc2c(=O)n1Cc1ccccc1,[Pd],CCO,,,,val
US20090170894A1,CC(C)(C)OC(=O)N1C2C=C(OS(=O)(=O)C(F)(F)F)CC1CC2.Cl>>Cl.O=S(=O)(OC1=CC2CCC(C1)N2)C(F)(F)F,,C1COCCO1,,,,val
US20140378446A1,CI.Cc1ccc(NC(=O)OC(C)(C)C)cc1[N+](=O)[O-]>>Cc1ccc(N(C)C(=O)OC(C)(C)C)cc1[N+](=O)[O-],,C1CCOC1,,[H-].[Na+],,val
US20070249688A1,CCC(Oc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)c1ccc(C(=O)NCCC(=O)OC)cc1>>CCC(Oc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)c1ccc(C(=O)NCCC(=O)O)cc1,,CO,,[Na+].[OH-],,val
US20070010542A1,Cc1ncccc1C#C[Si](C)(C)C>>CCc1cccnc1C,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05869724,C=C[Si](C)(Cl)CCCCCCCCCCCCCCCCCC.CCCCCCCC[SiH](C)Cl>>CCCCCCCCCCCCCCCCCC[Si](C)(Cl)CC[Si](C)(Cl)CCCCCCCC,,CCOC(C)=O,,,,val
US20130065893A1,CC(C)(C)OO.N#Cc1ccc([C@@H]2CCc3cncn32)c(F)c1>>N#Cc1ccc([C@@H]2CC(=O)c3cncn32)c(F)c1,Cl[Fe](Cl)Cl,c1ccncc1,,O,,val
US05750531,Cc1cc(F)ccc1N.Cc1nc(N2CCc3ccccc3C2)nc(Cl)c1C>>Cc1cc(F)ccc1Nc1nc(N2CCc3ccccc3C2)nc(C)c1C.Cl,,CN(C)C=O,,,,val
US20140200227A1,CC(=O)OC1CCc2c1ncc([N+](=O)[O-])c2N1C[C@H](C(F)(F)F)C[C@H](NC(=O)OC(C)(C)C)C1>>CC(=O)OC1CCc2c1ncc(N)c2N1C[C@H](C(F)(F)F)C[C@H](NC(=O)OC(C)(C)C)C1,[Fe],CCOC(C)=O,,CC(=O)O,,val
US20120035196A1,CC(C)(C)O.N#CC=C1c2ccc(C(=O)O)cc2CC12CC2.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)Nc1ccc2c(c1)CC1(CC1)C2=CC#N,,Cc1ccccc1,O,CCN(CC)CC,,val
US20090264444A1,CCOC(=O)c1sc(N2CCNC2=O)nc1C.FC1(F)CC1CBr>>CCOC(=O)c1sc(N2CCN(CC3CC3(F)F)C2=O)nc1C,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20080194572A1,COC(=O)[C@H](C)N(Cc1ncc(C)c(OC)c1C)c1nc(N)ncc1[N+](=O)[O-]>>COc1c(C)cnc(CN2c3nc(N)ncc3NC(=O)[C@@H]2C)c1C,[Fe],CC(=O)O,,,,val
US20150376174A1,CC(C)COc1ccc(C#N)cc1-n1ccnc1.CC(O)=S>>CC(C)COc1ccc(C(N)=S)cc1-n1ccnc1,,CC(=O)O,,,,val
US20150126498A1,COc1ncc(NS(=O)(=O)c2ccccc2N)cc1C.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1ncc(N2C(=O)Nc3ccccc3S2(=O)=O)cc1C,,C1COCCO1,,,,val
US20150133428A1,CCOC(=O)C1CC(=O)C1.COc1ccc([Mg]Br)cc1>>CCOC(=O)C1CC(O)(c2ccc(OC)cc2)C1,,CCOCC,,,,val
US20100029782A1,CCOC(=O)CCc1ccc(Cl)c([C@H](O)CO)c1.Cc1ccc(S(=O)(=O)Cl)cc1>>CCOC(=O)CCc1ccc(Cl)c([C@H](O)COS(=O)(=O)c2ccc(C)cc2)c1,,c1ccncc1,,CCOCC,Cl,val
US20140243302A1,CCOC=C(C(=O)OCC)C(=O)OCC.COc1ccc(N)cc1F>>CCOC(=O)c1cnc2cc(F)c(OC)cc2c1O,,Cc1ccccc1,,c1ccc(Oc2ccccc2)cc1,,val
US20120196864A1,COc1cc(C=O)ccc1O.Fc1ccc(C(F)(F)F)cc1Cl>>COc1cc(C=O)ccc1Oc1ccc(C(F)(F)F)cc1Cl,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040127574A1,CCCCI.O=C(NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1ccc(O)cc1)c1cccc2c1C=CCCC2>>CCCCOc1ccc(C(O)C(Cc2cccc(OC(F)(F)C(F)F)c2)NC(=O)c2cccc3c2C=CCCC3)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20020068758A1,CCC(OC)c1c(OCc2ccccc2)c(=O)cc(C)n1C.Cl>>CCC(OC)c1c(O)c(=O)cc(C)n1C.Cl,[Pd],CO,O,,,val
US20040048857A1,CCCc1cc(-c2ccc(-c3ccc(CCC(COC(C)=O)(COC(C)=O)NC(C)=O)cc3)cc2)no1>>CCCc1cc(-c2ccc(-c3ccc(CCC(N)(CO)CO)cc3)cc2)no1,,C1CCOC1,O,[Li+].[OH-],,val
US20080027094A1,CCI.O=Cc1ccc(C=CC(=O)O)cc1>>CCOC(=O)/C=C/c1ccc(C=O)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US08778939B2,O=C(Nc1cccnc1)c1cc(Br)ccc1OCc1ccc(F)c(F)c1.OB(O)c1ccncc1>>O=C(Nc1cccnc1)c1cc(-c2ccncc2)ccc1OCc1ccc(F)c(F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20060074087A1,Cl.FC(F)(F)c1ccc2c(n1)CN(C(c1ccccc1)(c1ccccc1)c1ccccc1)CC2>>Cl.FC(F)(F)c1ccc2c(n1)CNCC2,,C1COCCO1,CO,,,val
US20100152158A1,COc1cc(C)c(S(=O)(=O)N2CCCCC2CCCS(=O)(=O)Cl)c(C)c1.c1cc(N2CCC3(CCNCC3)CC2)ccn1>>COc1cc(C)c(S(=O)(=O)N2CCCCC2CCCS(=O)(=O)N2CCC3(CCN(c4ccncc4)CC3)CC2)c(C)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140315928A1,CC(C)(C)OC(=O)N1CCC[C@@H](N)C1.Cc1ccc[n+]([O-])c1Cl>>Cc1ccc[n+]([O-])c1N[C@@H]1CCCN(C(=O)OC(C)(C)C)C1,CN(C)c1ccncc1,CCCCO,,CCN(C(C)C)C(C)C,O,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4cc(OC)ccc4OC)nc(Cl)c3n2)cc1.COc1ccc(N)cc1OC>>COc1ccc(OC)c(-c2nc(Nc3ccc(OC)c(OC)c3)c3[nH]ncc3n2)c1,C1COCCO1,CO,,Cl,,val
US20090062358A1,CC(C)(C)OC(=O)NN.Cc1ccc(C=O)cc1>>Cc1ccc(CN(N)C(=O)OC(C)(C)C)cc1,[Pd],CC(C)O,O,,,val
US20100150831A1,COc1cccc([N+](=O)[O-])c1N1CCCN(Cc2cnc(-c3ccccc3)s2)CC1>>COc1cccc(N)c1N1CCCN(Cc2cnc(-c3ccccc3)s2)CC1,[Pd],CCOC(C)=O,,[H][H],,val
US20100150831A1,CCOC(=O)C(=O)C=CN(C)C.NN>>CCOC(=O)c1cc[nH]n1,,CCO,,Cl,Cl,val
US20110230483A1,COc1ccc(CNC(C)(C#N)C(F)(F)F)cc1>>COc1ccc(CNC(C)(CN)C(F)(F)F)cc1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20070072893A1,Br[Mg]c1ccccc1.O=CCCCn1cnc2cnc3ccccc3c21>>OC(CCCn1cnc2cnc3ccccc3c21)c1ccccc1,,C1CCOC1,,,,val
US20020032210A1,CCCCOB(OCCCC)OCCCC.Cc1ccc(I)cc1>>Cc1ccc(B(O)O)cc1,,CCOCC,,[Li]CCCC,,val
US20120157436A1,CC(=O)CCl.CCOC(=O)C(N)=S>>CCOC(=O)c1nc(C)cs1,,CCO,,,,val
US04105789,COC(=O)CC(C)C(=O)N[C@@H](C)C(=O)OCc1ccccc1>>COC(=O)CC(C)C(=O)N[C@@H](C)C(=O)O,[Pd],CCO,,,,val
US20150018547A1,COC(=O)Cc1c(C)sc2cc(O)cc(Cl)c12.Cc1nc(C(F)(F)F)ccc1CO>>COC(=O)Cc1c(C)sc2cc(OCc3ccc(C(F)(F)F)nc3C)cc(Cl)c12,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20130331377A1,CCCc1cc(=O)[nH]c(=S)[nH]1.CI>>CCCc1cc(=O)[nH]c(SC)n1,,O,,[Na+].[OH-],,val
US20110028467A1,COc1ccc(C(=O)Cl)cc1Cl.c1cc2c(cn1)OCCN2>>COc1ccc(C(=O)N2CCOc3cnccc32)cc1Cl,,ClCCl,,CCN(CC)CC,Cl,val
US05136080,Cc1nc(N)nc(N)c1-c1cc([N+](=O)[O-])ccc1Cl>>Cc1nc(N)nc(N)c1-c1cc(N)ccc1Cl,O=[Pt]=O,CC(=O)O,,,,val
US20140205537A1,CC(C)I.O=[N+]([O-])c1cc(F)c(O)cc1F>>CC(C)Oc1cc(F)c([N+](=O)[O-])cc1F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100152445A1,O=C(Nc1ccc(C2CCNCC2)cc1)c1cc(-c2ccccc2)cs1.O=C(O)c1ccc(F)nc1>>O=C(O)c1ccc(N2CCC(c3ccc(NC(=O)c4cc(-c5ccccc5)cs4)cc3)CC2)nc1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20100204272A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.N#Cc1ccc(O)c(N)c1>>CC(C)(C)OC(=O)N1CCC(Nc2cc(C#N)ccc2O)CC1,,C1CCOC1,,CC(=O)O,[BH3-]C#N.[Na+],val
US20090156642A1,CCOC(=O)C#CC(=O)OCC.NNc1cccc(F)c1F>>CCOC(=O)c1cc(O)n(-c2cccc(F)c2F)n1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100179128A1,CCCCCn1c(=O)n(CCCOC2CCCCO2)c(=O)c2[nH]c(Cl)nc21>>CCCCCn1c(=O)n(CCCO)c(=O)c2[nH]c(Cl)nc21,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05723119,CC(C)=O.CO.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-]>>CC(C)=O.CO.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-],,CO,,,,val
US20140221339A1,CI.COC(=O)c1cccc2[nH]c(S)nc12>>COC(=O)c1cccc2[nH]c(SC)nc12,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20160264575A1,CC(C)(C)OC(=O)N1Cc2c(c3ccccc3n2Cc2ccc(F)cc2)CC1CO.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1Cc2c(c3ccccc3n2Cc2ccc(F)cc2)CC1COS(C)(=O)=O,,ClCCl,O,CCN(CC)CC,,val
US20150065507A1,Cc1cnc(N)c(C)c1.Cc1noc(C)c1COc1ccc(S(=O)(=O)Cl)cc1>>Cc1cnc(NS(=O)(=O)c2ccc(OCc3c(C)noc3C)cc2)c(C)c1,,ClCCl,,O,c1ccncc1,val
US20110172237A1,Nc1ccncc1F.O=C(Cl)CCl>>O=C(CCl)Nc1ccncc1F,,ClCCl,,CCN(CC)CC,,val
US06479531B1,COCC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1>>O=C(O)c1cccc(NC(=O)c2nc(C3(CO)CCCCC3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)c1,,ClCCl,,BrB(Br)Br,O,val
US20090156607A1,CCS.Cn1cnc(C#N)c1C(=O)O>>CCSC(=O)c1c(C#N)ncn1C,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20050075373A1,CCOC(C)=NC(=O)c1cc(OC)cc(OC)c1.NNc1ccc(S(N)(=O)=O)cn1>>COc1cc(OC)cc(-c2nc(C)nn2-c2ccc(S(N)(=O)=O)cn2)c1,,CO,ClCCl,O,,val
US20070219230A1,CC(=O)Cl.COc1ccc(CCN)cc1>>COc1ccc(CCNC(C)=O)cc1,,ClCCl,,[Na+].[OH-],,val
US20130129753A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@@H](N)Cc1ccc2ncccc2c1>>COC(=O)[C@H](Cc1ccc2ncccc2c1)NC(=O)OC(C)(C)C,,O,,CCN(CC)CC,CO,val
US20050038016A1,CN=Cc1cccc(OCSC)c1>>CNCc1cccc(OCSC)c1,,CCO,,[BH4-].[Na+],,val
US20100216806A1,COC(=O)c1ccc(Br)c(F)c1>>OCc1ccc(Br)c(F)c1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20120088755A1,Cc1nc2cc(N)cc(C)c2o1.Clc1cc(Cl)ncn1>>Cc1nc2cc(Nc3cc(Cl)ncn3)cc(C)c2o1,,CCCCO,,,,val
US20130158003A1,CN(C)S(=O)(=O)n1cc(-c2ccccc2)nc1CNC(=O)OCc1ccccc1>>CN(C)S(=O)(=O)n1cc(-c2ccccc2)nc1CN,[Pd],CN(C)C=O,,,,val
US20040180911A1,NC[C@@H]1C[C@@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1.O=C(Cl)CCl>>Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@@H]1C[C@@H](CNC(=O)CCl)C1,,CC#N,,CCN(CC)CC,,val
US20040209921A1,CC(C)(C)OC(=O)NCCc1c[nH]cn1.CI>>Cn1cnc(CCNC(=O)OC(C)(C)C)c1,,C1CCOC1,,[H-].[Na+],,val
US20120264737A1,CCc1cc(CC)c(C(=O)O)cc1I.COC(=O)Cl>>CCc1cc(CC)c(C(=O)OC)cc1C(=O)O,,C1CCOC1,C1CCOC1,[Li]CCCC,,val
US20100069328A1,CN1CCCC1CCC(C(=O)O)c1ccc(Br)cc1.CO>>COC(=O)C(CCC1CCCN1C)c1ccc(Br)cc1,,O=S(Cl)Cl,,,,val
US20020001591A1,N=C(N)NCCC[C@H](N)C(=O)O.O=C(Cl)C1CCCC1>>N=C(N)NCCC[C@H](NC(=O)C1CCCC1)C(=O)O,,[Na+],[OH-],Cl,,val
US20050272732A1,CCC(N)c1nnc(C2CCCO2)[nH]c1=O.O=C(Cl)C1CCCC1>>CCC(NC(=O)C1CCCC1)c1nnc(C2CCCO2)[nH]c1=O,,ClCCl,,CCN(CC)CC,,val
US20090054407A1,CCCNCC.COc1cc(-c2cc3cc(C=O)ccc3n2C(=O)OC(C)(C)C)c2c(c1OS(C)(=O)=O)CNC2=O>>CCCN(CC)Cc1ccc2c(c1)cc(-c1cc(OC)c(OS(C)(=O)=O)c3c1C(=O)NC3)n2C(=O)OC(C)(C)C,,CC#N,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20110144066A1,CCCCCCCCCCCCCCCCCCc1ccccc1.O=S(=O)(O)Cl>>CCCCCCCCCCCCCCCCCCc1ccc(S(=O)(=O)Cl)cc1,,ClC(Cl)Cl,,,,val
US20080090802A1,CC(C)(C)NC(=O)CNC(=O)c1cc(Br)ccc1N.O=Cc1cccc(Cl)c1>>CC(C)(C)NC(=O)CN1C(=O)c2cc(Br)ccc2NC1c1cccc(Cl)c1,CC(=O)O,CCO,,,,val
US20090012279A1,CN(C)c1cccc2c(S(=O)(=O)NCCC(=O)O)cccc12.O=C(Cl)C(=O)Cl>>CN(C)c1cccc2c(S(=O)(=O)NCCC(=O)Cl)cccc12,CN(C)C=O,ClCCl,,,,val
US20110301082A1,CCCCOC(=O)CCNC(=O)c1ccc(C(CCC)C(c2ccc(Cl)cc2)c2nn(C)c3c(Cl)cc(C(F)(F)F)cc23)cc1>>CCCC(c1ccc(C(=O)NCCC(=O)O)cc1)C(c1ccc(Cl)cc1)c1nn(C)c2c(Cl)cc(C(F)(F)F)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130143899A1,CCCS(=O)(=O)Nc1ncc(F)c(Nc2nccnc2-c2cc(SC)ncn2)c1F.CCN>>CCCS(=O)(=O)Nc1ncc(F)c(Nc2nccnc2-c2cc(NCC)ncn2)c1F,,CC(C)O,,,,val
US20020061897A1,COC(=O)CC(C)=O.Nc1cc(-c2ccccc2)n[nH]1>>Cc1cc(O)n2nc(-c3ccccc3)cc2n1,,CC(=O)O,,,,val
US20050277652A1,CN(C)CC1CCN(C(=O)Nc2cc(Oc3ccc(N)cc3F)ncn2)CC1.O=C(Cc1ccc(F)cc1)N=C=S>>CN(C)CC1CCN(C(=O)Nc2cc(Oc3ccc(NC(=S)NC(=O)Cc4ccc(F)cc4)cc3F)ncn2)CC1,,CCO,Cc1ccccc1,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US20100179128A1,C=CCn1c(Cl)nc2[nH]c(=O)[nH]c(=O)c21.FC(F)(F)CI>>C=CCn1c(Cl)nc2c1c(=O)[nH]c(=O)n2CC(F)(F)F,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20100004292A1,Cn1cc(C(=O)Nc2ccc(NCCO[Si](C)(C)C(C)(C)C)cc2)c(NC(=O)c2ccc(Cl)s2)n1.N#CBr>>Cn1cc(C(=O)Nc2ccc(N(C#N)CCO[Si](C)(C)C(C)(C)C)cc2)c(NC(=O)c2ccc(Cl)s2)n1,,CCOCC,,O=C([O-])O.[Na+],,val
US05492912,CN(CCNC(C1CC1)C1CC1)Cc1ccccc1>>CNCCNC(C1CC1)C1CC1,[Pd],CCO,,,,val
US20090286812A1,CC(C)c1noc([C@@H]2CC[C@@H](n3ncc4c(Cl)ncnc43)CC2)n1.CS(=O)(=O)c1ccc(O)c(F)c1>>CC(C)c1noc([C@@H]2CC[C@@H](n3ncc4c(Oc5ccc(S(C)(=O)=O)cc5F)ncnc43)CC2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100075948A1,CC(C)(C)OC(=O)CN.CCC(=O)CC>>CCC(CC)=NCC(=O)OC(C)(C)C,,CCO,,,,val
US20140045823A1,CCOC(=O)c1cc(-c2ccc(C#N)c(F)c2)on1>>N#Cc1ccc(-c2cc(C(=O)O)no2)cc1F,,C1CCOC1,,[Na+].[OH-],,val
US20080221192A1,O=C1Cc2ccc(NC(=O)Nc3cccc([N+](=O)[O-])c3)cc2N1>>Nc1cccc(NC(=O)Nc2ccc3c(c2)NC(=O)C3)c1,[Pd],CN(C)C=O,CO,,,val
US20080312226A1,Cn1cc(C(=O)O)c2ccccc21.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>Cn1cc(NC(=O)N2CCN(c3nc(-c4ccccc4)ns3)CC2)c2ccccc21,,Cc1ccccc1,O,CCN(CC)CC,,val
US20080045555A1,CCCCCNc1nc[nH]c1C#N.NNC(=O)c1ccccc1>>CCCCCNc1nc[nH]c1-c1nc(-c2ccccc2)n[nH]1,,CCCCO,O,O=C([O-])[O-].[K+].[K+],,val
US04409238,CC(C)C(C=C(Cl)Cl)C(=O)Cl.N#CC(O)c1cccc(Oc2ccccc2)c1>>CC(C)C(C=C(Cl)Cl)C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1,,CCOCC,c1ccccc1,c1ccncc1,,val
US20150057265A1,C=O.COC(=O)c1c(NC(=O)OC(C)(C)C)sc2cc(C3CNC3)cnc12>>COC(=O)c1c(NC(=O)OC(C)(C)C)sc2cc(C3CN(C)C3)cnc12,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080312282A1,O=C(O)CBr.OC1(c2ccc(Cl)c(F)c2)CCC1>>O=C(O)COC1(c2ccc(Cl)c(F)c2)CCC1,,CN(C)C=O,,[H-].[Na+],,val
US20050043388A1,NNC(=O)COc1ccc([N+](=O)[O-])cc1.O=C1Nc2ccc(I)cc2C1=O>>O=C(COc1ccc([N+](=O)[O-])cc1)NN=C1C(=O)Nc2ccc(I)cc21,,CC(=O)O,,,,val
US20070265278A1,Cc1ccc(Br)cc1.O=S(=O)(O)Cl>>Cc1ccc(Br)cc1S(=O)(=O)Cl,,ClCCl,,,,val
US20140057893A1,Cc1cc(OCc2ccccc2)ccc1CC(=O)OC(C)(C)C>>Cc1cc(OCc2ccccc2)ccc1CC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050032786A1,CS(=O)c1cc(CCC(=O)OC(C)(C)C)cc(-c2nc(=O)c3ccccc3s2)n1>>CS(=O)c1cc(CCC(=O)O)cc(-c2nc(=O)c3ccccc3s2)n1,,O=C(O)C(F)(F)F,,CC(C)OC(C)C,,val
US04012499,CN(C)CCCCl.O=C1c2ccccc2S(=O)(=O)c2cc(-c3nnn[nH]3)ccc21>>CN(C)CCCn1nnc(-c2ccc3c(c2)S(=O)(=O)c2ccccc2C3=O)n1,,CCO,,Cl,[Na],val
US20130184287A1,Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ccc2c(NC(=O)C3CC3)nn(COCC[Si](C)(C)C)c2c1.O=C(O)C(F)(F)F>>Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ccc2c(NC(=O)C3CC3)n[nH]c2c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20080227770A1,BrCc1ccccc1.CCOC(=O)Cc1cnc(C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)CO[Si](C)(C)C(C)(C)C)C2=O)s1>>CCOC(=O)C(Cc1ccccc1)c1cnc(C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)CO[Si](C)(C)C(C)(C)C)C2=O)s1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20070287842A1,CCOC(=O)c1c(N=Cc2cccs2)sc(N=Cc2cccs2)c1C(=O)OCC.O=Cc1ccc([N+](=O)[O-])s1>>CCOC(=O)c1c(N=Cc2cccs2)sc(N=Cc2ccc([N+](=O)[O-])s2)c1C(=O)OCC,Cl[Ti](Cl)(Cl)Cl,Cc1ccccc1,,C1CN2CCN1CC2,,val
US20160272632A1,CC(C)(C)OC(=O)N1CCC(N)CC1.O=S(=O)(Cl)c1ccc(Br)cc1CBr>>CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2ccc(Br)cc2CBr)CC1,,ClCCl,,CCN(CC)CC,,val
US20120142686A1,CN.O=C(O)c1c2cc(C3CC3)c([N+](=O)[O-])cc2nn1-c1ccc(Br)cc1>>CNC(=O)c1c2cc(C3CC3)c([N+](=O)[O-])cc2nn1-c1ccc(Br)cc1,,c1ccncc1,,O=P(Cl)(Cl)Cl,,val
US06169086A,COc1cnccn1.II>>COc1nccnc1I,,C1CCOC1,CCOC(C)=O,CC(C)NC(C)C,[Li]CCCC,val
US05993780,CC(=O)OCc1c(I)c(NC(=O)C2COC(C)(C)O2)c(I)c(C(=O)NCC(COC(C)=O)OC(C)=O)c1I>>O=C(NCC(O)CO)c1c(I)c(CO)c(I)c(NC(=O)C(O)CO)c1I,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20160221994A1,CC1(C)COCCN1.O=C(Cl)c1ccc(Br)cc1>>CC1(C)COCCN1C(=O)c1ccc(Br)cc1,,ClCCl,,CCN(CC)CC,,val
US20140275027A1,C=O.c1cc(NCC2CCOCC2)nc(-c2ccnc3[nH]c(C4CCNCC4)cc23)c1>>CN1CCC(c2cc3c(-c4cccc(NCC5CCOCC5)n4)ccnc3[nH]2)CC1,,CO,ClCCl,O,[BH3-]C#N.[Na+],val
US20120165345A1,CC1(C)OB(c2cnn(-c3cccnc3)c2)OC1(C)C.CS(=O)(=O)NC(=O)c1csc(Br)n1>>CS(=O)(=O)NC(=O)c1csc(-c2cnn(-c3cccnc3)c2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US04483868,COc1ccc(OC)c(C(=O)CC(O)C(=O)O)c1>>COc1ccc(OC)c(C(=O)C=CC(=O)O)c1,,CC(=O)O,,Cl,,val
US20050282863A1,ClCCCCCBr.c1ccc2c(c1)SCCc1c-2[nH]c2ccccc12>>ClCCCCCn1c2c(c3ccccc31)CCSc1ccccc1-2,,CN(C)C=O,,O,[H-].[Na+],val
US20050107364A1,CC(C)(C)OC(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(C1=C(O)c3ccccc3C(C)(CC3CC3)C1=O)N2>>CC1(CC2CC2)C(=O)C(C2=NS(=O)(=O)c3cc(N)ccc3N2)=C(O)c2ccccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080031852A1,CC(C)CCn1c(=O)oc(=O)c2cccn21.CCOC(=O)CC(=O)OCC>>CCOC(=O)c1c(O)c2cccn2n(CCC(C)C)c1=O,CO,CC(=O)N(C)C,,[H-].[Na+],,val
US20100105659A1,COc1cccc(S)c1.N#Cc1ncc(Br)cc1Oc1ccc(F)cc1Br>>COc1cccc(Sc2cnc(C#N)c(Oc3ccc(F)cc3Br)c2)c1,,CN(C)C=O,,[H-].[Na+],,val
US05399702,NC(CO)(CO)CO.O=C(Cc1ccccc1C(=O)O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1>>NC(CO)(CO)CO.O=C(Cc1ccccc1C(=O)O)Nc1cccc(C=Cc2nc(C3CCC3)cs2)c1,,CCO,,,,val
US20100298290A1,CC1(C)CCc2ncnc(N3CCOc4ccc(-c5cnc(N)c(N)c5)cc4C3)c2C1.COC(=O)N=C(NC(=O)OC)SC>>COC(=O)Nc1nc2ncc(-c3ccc4c(c3)CN(c3ncnc5c3CC(C)(C)CC5)CCO4)cc2[nH]1,,CC(=O)O,,,,val
US20120107959A1,C=CC(=O)NC(C)C.C=CS(=O)(=O)O>>C=CC(=O)NC(C)C.C=CS(=O)(=O)O,,O,,,,val
US06608059B1,CC(C)CNC(=O)c1cc2cc(OCc3c(Cl)cccc3Cl)ccc2n1CCCC#N.C[Si](C)(C)N=[N+]=[N-]>>CC(C)CNC(=O)c1cc2cc(OCc3c(Cl)cccc3Cl)ccc2n1CCCc1nnn[nH]1,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US20060148858A1,CCC(O)c1cn(-c2ccc(C(F)(F)F)cn2)nc1C.COC(=O)Cc1cc(O)nn1C>>Cc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1cc(CC(=O)O)n(C)n1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20080009530A1,BrC(Br)(Br)Br.OCc1ccc(C(F)(F)F)cc1Cl>>FC(F)(F)c1ccc(CBr)c(Cl)c1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130245049A1,Cc1ccc(C(=O)CBr)cc1.N#CN=C1CCCCN1>>Cc1ccc(C(=O)CN2CCCCC2=NC#N)cc1,,CC#N,,[K],,val
US20100035906A1,Cl.NCc1ccnc(-n2[nH]cc(-c3cccnc3)c2=O)c1.O=C(Cl)c1ccccc1>>Cl.O=C(NCc1ccnc(-n2[nH]cc(-c3cccnc3)c2=O)c1)c1ccccc1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US04436748,CC(O)c1cc2cc(O)c(Cl)c(Cl)c2s1.CCOC(=O)CBr>>CCOC(=O)COc1cc2cc(C(C)O)sc2c(Cl)c1Cl,,CCC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06521643B1,CC(=O)N(C)C.Cc1cc(OC(C)C)ccn1>>CC(=O)Cc1cc(OC(C)C)ccn1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20070112031A1,CCOC(=O)[C@@H]1C(=O)N(C)C(=O)C[C@H]1c1ccc(F)cc1>>CN1CC[C@@H](c2ccc(F)cc2)[C@H](CO)C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06326386B1,CC(C)(C)OC(=O)N(CCOc1cc(Cl)cc(C(=O)N(CCC#N)c2ccccc2Cl)c1)c1ccncc1.O=C(O)C(F)(F)F>>NC(=O)CCN(C(=O)c1cc(Cl)cc(OCCNc2ccncc2)c1)c1ccccc1Cl.O=C(O)C(F)(F)F,,ClCCl,,O,,val
US20100130558A1,[N-]=[N+]=N[C@@H]1CC[C@H]2CN(Cc3ccccc3)C[C@H]21>>N[C@@H]1CC[C@H]2CN(Cc3ccccc3)C[C@H]21,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080249101A1,C=CCOC(=O)c1ccc(NC2CCN(C(=O)OC(C)(C)C)CC2)c(N)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C=CCOC(=O)c1ccc2c(c1)[nH]c(=O)n2C1CCN(C(=O)OC(C)(C)C)CC1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US20140010783A1,CS/C(=N\C#N)Nc1cc(Cl)c(I)c(Cl)c1.NN>>Nc1nc(Nc2cc(Cl)c(I)c(Cl)c2)n[nH]1,,CCO,,,,val
US20120252815A1,CC(=O)OCCCCBr.CC1(C)CCC(C)(C)c2cc(-c3nc(C4CCNCC4)co3)ccc21>>CC1(C)CCC(C)(C)c2cc(-c3nc(C4CCN(CCCCO)CC4)co3)ccc21,,CO,,Cl,[Na+].[OH-],val
US07256196B1,CCNc1nc(Cl)ncc1[N+](=O)[O-].Oc1c(F)cccc1F>>CCNc1nc(Oc2c(F)cccc2F)ncc1[N+](=O)[O-],,CCN(C(C)C)C(C)C,,,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2cccc(C(=O)O)c2OC(C)=O)=C(C)C1=O.Nc1ccc(Cl)cc1Cl>>COC1=C(OC)C(=O)C(Cc2cccc(C(=O)Nc3ccc(Cl)cc3Cl)c2OC(C)=O)=C(C)C1=O,,ClCCl,,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US20100113450A1,CCOC(=O)CCCBr.CNC1CCCCC1>>CCOC(=O)CCCN(C)C1CCCCC1,,CCO,,,,val
US20090197871A1,CC1(C)C(=O)N(Br)C(=O)N1Br.Cc1cc(C)cc(Br)c1>>Cc1cc(Br)cc(CBr)c1,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20020165365A1,CC(C)(C)OC(=O)CN(CCNC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)Cn1cnc2c(NC(=O)OCc3ccccc3)nc(N)nc21>>Nc1nc(NC(=O)OCc2ccccc2)c2ncn(CC(=O)N(CCNC(=O)OCC3c4ccccc4-c4ccccc43)CC(=O)O)c2n1,,ClCCl,,CO,O=C(O)C(F)(F)F,val
US20060270686A1,CS(=O)(=O)Cl.Nc1cc(Br)cc(-c2nc3ccccc3o2)c1>>CS(=O)(=O)Nc1cc(Br)cc(-c2nc3ccccc3o2)c1,CN(C)c1ccncc1,c1ccncc1,,,,val
US04075346,O=C(c1ccccc1)C(CC(F)Br)[N+](=O)[O-].OC1(c2cccc(C(F)(F)F)c2)CCNCC1>>O=C(c1ccccc1)C(CC(F)N1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)[N+](=O)[O-],,Cc1ccccc1,O,[I-].[K+],,val
US04006148,CCC1=NC(C)(C)CO1.O=Cc1ccc(Cl)cc1Cl>>CC(=Cc1ccc(Cl)cc1Cl)C1=NC(C)(C)CO1,II,,,,,val
US20140061545A1,Brc1ccccc1-c1ccccc1.O=C1c2cc(Sc3ccccc3)ccc2-c2ccc(Sc3ccccc3)cc21>>c1ccc(Sc2ccc3c(c2)C2(c4ccccc4-c4ccccc42)c2cc(Sc4ccccc4)ccc2-3)cc1,,C1CCOC1,,O,[Li]CCCC,val
US20050090483A1,C=CCN.O=Cc1cccc2cc[nH]c12>>C=CCNCc1cccc2cc[nH]c12,,ClCCCl,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040235822A1,COc1cc(N)ccc1S.ClCc1cccnc1>>COc1cc(N)ccc1SCc1cccnc1,,CO,,Cl,[Na+].[OH-],val
US20140249196A1,CCOC(=O)[C@H](C)O.Cc1ccnc(F)c1>>CCOC(=O)[C@H](C)Oc1cc(C)ccn1,,CN(C)C=O,,[H-].[Na+],,val
US20050234109A1,COc1cccnc1Br.O=Cc1cc(F)ccc1F>>COc1cccnc1C(O)c1cc(F)ccc1F,,C1CCOC1,,CC(C)[Mg]Cl,[Cl-].[NH4+],val
US20110178041A1,CNc1cccn2cc(C(F)(F)F)nc12.O=C1CCC(=O)N1Br>>CNc1ccc(Br)n2cc(C(F)(F)F)nc12,,CN(C)C=O,,O,,val
US20110028444A1,C[C@@H]1Sc2c(C(=O)O)c(=O)c3cc(F)c(N4CCNCC4)cc3n21.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>C[C@@H]1Sc2c(C(=O)O)c(=O)c3cc(F)c(N4CCNCC4)cc3n21.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,,O,,,,val
US20140179667A1,Cc1cccc(F)c1C(=O)O.O=C1CCC(=O)N1Br>>Cc1c(Br)ccc(F)c1C(=O)O,,O=S(=O)(O)O,,,,val
US20110071141A1,COC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1COC(C)=O>>O=C1OCc2cc(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)ccc21,,CO,,C[O-].[Na+],,val
US20030171377A1,COC(=O)c1ccc2cc(O)ccc2c1.Cc1oc(-c2ccccc2)nc1CCO>>COC(=O)c1ccc2cc(OCCc3nc(-c4ccccc4)oc3C)ccc2c1,,C1CCOC1,CCOC(C)=O,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060111375A1,COc1cc2c(Cl)ccnc2cc1OCc1ccccc1.Cc1cc(O)c(-c2nc(C)c(C)s2)nc1C>>COc1cc2c(Oc3cc(C)c(C)nc3-c3nc(C)c(C)s3)ccnc2cc1OCc1ccccc1,CN(C)c1ccncc1,CS(C)=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04264467,CC1=C(CO)C=CCC1(C)C>>CC1C(CO)C=CCC1(C)C,[Ni],CCO,,,,val
US05994394,CCCC[Sn](Cl)(CCCC)CCCC.c1ccoc1>>CCCC[Sn](CCCC)(CCCC)c1ccco1,,C1CCOC1,,[Li]CCCC,,val
US20060223863A1,CCOP(=O)(Cl)OCC.CCOc1ccc2c(C#N)c(-c3ccc(N)cc3)n(CC)c2c1>>CCOc1ccc2c(C#N)c(-c3ccc(NP(=O)(OCC)OCC)cc3)n(CC)c2c1,,C1COCCO1,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US04753953,CC(=O)N(C)C1CNCC1C.O=C(O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O>>CC(=O)N(C)C1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)CC1C,,CC#N,,C1CCC2=NCCCN2CC1,,val
US04846875,COC(C)c1cc(NC(C)=O)c(F)cc1Cl>>COC(C)c1cc(N)c(F)cc1Cl,,O,,CO,[K+].[OH-],val
US04360464,COCOC1CN(C(C)C)C1.Oc1ccccc1>>COCOC(CNC(C)C)COc1ccccc1,,CCOCC,,[Na+].[OH-],,val
US05798054,CCOC(=O)/C=C/C(=O)OCC>>CCOC(=O)/C=C\C(=O)OCC,,Cc1ccc(C)cc1,,,,val
US04385176,CC1C=C(C(=O)O)N2C(=O)C(NC(=O)C(NOC(C)C3CC3)C3C=CC=CC3=C=O)[C@H]2S1>>CC1C=C(C(=O)O)N2C(=O)C(NC(=O)C(N)c3ccccc3)[C@H]2S1,,O=CO,,CCOCC,,val
US20120071450A1,CN1C(=O)c2c(nn(Cc3ccc(-c4ccccn4)cc3)c2Nc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12>>CN1Cc2c(nn(Cc3ccc(-c4ccccn4)cc3)c2Nc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12,,C1CCOC1,Cc1ccccc1,CC(C)C[AlH]CC(C)C,,val
US20050113413A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)NC1CCN(Cc2ccccc2)CC1>>CC(C)N(C(=O)OC(C)(C)C)C1CCN(Cc2ccccc2)CC1,,ClCCl,,,,val
US20120302566A1,COC(=O)C1CCOCC1.ClCCCI>>COC(=O)C1(CCCCl)CCOCC1,,C1CCOC1,CCOCC,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20110152286A1,CN1CCc2ccc(OCCCN3CCN(c4cccc5sccc45)CC3)cc2C1=O.CS(=O)(=O)O>>CN1CCc2ccc(OCCCN3CCN(c4cccc5sccc45)CC3)cc2C1=O.CS(=O)(=O)O,,CCO,,,,val
US20160096841A1,Nc1cccc(F)c1F.O=C1CCC(=O)N1Br>>Nc1ccc(Br)c(F)c1F,,CC#N,,O,,val
US20150225397A1,Cc1nc(-c2ccc(-c3cncnc3)cc2)c2c(n1)[C@@]1(c3ccccc3)CC(C#N)C(=O)[C@@H](C)[C@@H]1CC2>>Cc1nc(-c2ccc(-c3cncnc3)cc2)c2c(n1)[C@@]1(c3ccccc3)C=C(C#N)C(=O)[C@@H](C)[C@@H]1CC2,,C1CCOC1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20140378483A1,C=c1nc(-c2ccccc2)oc(=O)/c1=C/C(=C\C)C(=O)c1c(C)cc2ccccn12.O=C1CCC(=O)N1Br>>C=c1nc(-c2ccccc2)oc(=O)/c1=C/C(=C\C)C(=O)c1c(C)c(Br)c2ccccn12,,CN1CCCC1=O,ClCCl,,,val
US20110245250A1,CC(C)(C)OC(=O)CNC(=O)Cc1ccc([N+](=O)[O-])cc1>>CC(C)(C)OC(=O)CNC(=O)Cc1ccc(N)cc1,[Pd],CO,,,,val
US20070066583A1,COc1cc(N2CCN(C(=O)CCl)CC2)ccc1Cl.O=C1NC(c2ccccc2)CO1>>COc1cc(N2CCN(C(=O)CN3C(=O)OCC3c3ccccc3)CC2)ccc1Cl,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060194787A1,C=CCCC(C)=NCC=C>>C=CCCC(C)NCC=C,,CO,,[BH4-].[Na+],,val
US20160244437A1,Cc1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nnn[nH]3)cc2)cc1-c1cccc(C(=O)NC2CCN(C(C)C)CC2)c1.Cl>>Cc1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc(-c3nnn[nH]3)cc2)cc1-c1cccc(C(=O)NC2CCN(C(C)C)CC2)c1.Cl,,C1COCCO1,,CC#N,,val
US20080300239A1,Brc1ccc2nccc(-c3ccncc3)c2c1.CS(=O)(=O)c1cncc(B(O)O)c1>>CS(=O)(=O)c1cncc(-c2ccc3nccc(-c4ccncc4)c3c2)c1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20160060267A1,CC(C)n1cc(I)cn1.O=S(=O)(c1ccccc1)N(F)S(=O)(=O)c1ccccc1>>CC(C)n1ncc(I)c1F,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20110152318A1,CC(=O)c1cccc(B(O)O)c1.CC(NC(=O)c1coc(Cl)n1)c1cc(F)c(NS(C)(=O)=O)c(F)c1>>CC(=O)c1cccc(-c2nc(C(=O)NC(C)c3cc(F)c(NS(C)(=O)=O)c(F)c3)co2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04539319,COc1ccc(Br)c2c1CCCC2.N.c1ccncc1>>COC1(C#N)CC=CC2=C1CCCC2,,CN(C)P(=O)(N(C)C)N(C)C,,,,val
US20130190332A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4ccccn4c3-c3ccccc3)cc2)CCC1>>NC1(c2ccc(-c3nc4ccccn4c3-c3ccccc3)cc2)CCC1,,CO,ClCCl,C1COCCO1,Cl,val
US20080161294A1,CCOC(=O)c1ccc(F)c(Cl)c1.c1cn[nH]c1>>CCOC(=O)c1ccc(-n2cccn2)c(Cl)c1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20060205794A1,BrC1CCCCC1.Sc1cccc(Br)c1>>Brc1cccc(SC2CCCCC2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050137186A1,CCCN1CCc2ccc(CO)cc2CC1.CS(=O)(=O)Cl>>CCCN1CCc2ccc(CCl)cc2CC1,,ClCCl,,CCN(CC)CC,,val
US20060074111A1,CCOC(=O)COc1ccc(CBr)cc1C.COCCNc1cccc(-c2ccc(C(F)(F)F)cc2)c1>>CCOC(=O)COc1ccc(CN(CCOC)c2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1C,,CC#N,,CCN(C(C)C)C(C)C,,val
US20160009683A1,CCOC(=O)C(F)(F)c1cccc(C=O)c1.CN1CCNCC1>>CCOC(=O)C(F)(F)c1cccc(CN2CCN(C)CC2)c1,,CCO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20150336947A1,Cc1nc2ccccc2c2ccn(S(=O)(=O)c3ccccc3)c12>>Cc1nc2ccccc2c2cc[nH]c12,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20120283297A1,CC(C)Oc1ccc(-c2nc(-c3cccc4[nH]ncc34)no2)cc1Cl.COC(=O)C(C)CBr>>COC(=O)C(C)Cn1ncc2c(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)cccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050065178A1,C1CCC2=NCCCN2CC1.ClCCl.Clc1cc(-c2ccccc2)no1>>CN1CC2CN(c3cc(-c4ccccc4)no3)CC2C1,,ClCCl,,,,val
US20120258953A1,Cc1nc2ccc(-c3ccc4c(c3)CN(C(=O)N3CCCCC3c3ccccc3)CCO4)cc2[nH]1>>Cc1nc2ccc(-c3ccc4c(c3)CN(C(=O)N3CCCC[C@@H]3c3ccccc3)CCO4)cc2[nH]1,,CCO,CO,,,val
US04894386,CCCCNC(=O)Cc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C.Cc1ccccc1S(N)(=O)=O>>CCCCNC(=O)Cc1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20060264486A1,CC#N.CN1CCc2cc(Cl)c(O)cc2C(c2cccc(N=C=S)c2)C1.O.O=C(O)C(F)(F)F>>C[C@H](C(=O)O)n1ccc2cc(OCc3ccccc3)ccc21,,CC#N,O,,,val
US20030033089A1,C1CNCCN1.ClCc1nc(-c2ccc3c(c2)OCO3)c2cc3c(cc2n1)OCO3>>c1cc2c(cc1-c1nc(CN3CCNCC3)nc3cc4c(cc13)OCO4)OCO2,,CCO,,,,val
US20110313151A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CC=O)CC1.c1cc2sccc2c(N2CCNCC2)n1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4sccc34)CC2)CC1,,ClCCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US04968835,Nc1ccccc1Cl.O=S(=O)(O)O>>Nc1ccc(S(=O)(=O)O)cc1Cl,,Clc1ccccc1Cl,,,,val
US05356906,O=C1c2ccccc2C(=O)N1CC1CCN(CCc2ccccc2)CC1>>NCC1CCN(CCc2ccccc2)CC1,,CCO,,NN,,val
US20060270637A1,CC(=O)OC(C)=O.O=C1OC(CO)CN1c1cccc(F)c1>>CC(=O)OC[C@H]1CN(c2cccc(F)c2)C(=O)O1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20030186943A1,BrP(Br)Br.CCCOc1ccc(CO)cc1OC>>CCCOc1ccc(CBr)cc1OC,,CCOCC,,,,val
US20070244136A1,Cc1ccc(Oc2ccc(Nc3ncnc4cccc(O[C@H](C)CN)c34)cc2C)cn1.O=C=NCCCl>>Cc1ccc(Oc2ccc(Nc3ncnc4cccc(O[C@H](C)CNC(=O)NCCCl)c34)cc2C)cn1,,ClCCl,,,,val
US20120214769A1,CC(C)(C)c1ccc([C@H](Cc2ccc(C(=O)O)cc2)c2cc(-c3cccc(-c4ccc(Cl)cc4)c3)on2)cc1.NCCS(=O)(=O)O>>CC(C)(C)c1ccc([C@H](Cc2ccc(C(=O)NCCS(=O)(=O)O)cc2)c2cc(-c3cccc(-c4ccc(Cl)cc4)c3)on2)cc1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20140336198A1,CC(C)(C)OC(=O)N1CC(C(=O)c2ccc(OC(F)F)cc2)C1.NO>>CC(C)(C)OC(=O)N1CC(C(=NO)c2ccc(OC(F)F)cc2)C1,,CO,O,Cl,CC(=O)[O-].[Na+],val
US20110124665A1,COC(=O)CCCc1ccc(Nc2ncnc3oc(-c4ccccc4)c(-c4ccc(OC)cc4)c23)cc1>>COc1ccc(-c2c(-c3ccccc3)oc3ncnc(Nc4ccc(CCCC(=O)O)cc4)c23)cc1,,C1CCOC1,,[Na+].[OH-],,val
US20100152235A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1c(O)ccc2c1CCNC2>>Cc1c(O)ccc2c1CCN(C(=O)OC(C)(C)C)C2,,ClCCl,,CCN(CC)CC,,val
US20020035102A1,COc1ccc(C(=C2CN(C(c3ccccc3)c3ccccc3)C2)S(C)(=O)=O)cc1>>CS(=O)(=O)C(=C1CN(C(c2ccccc2)c2ccccc2)C1)c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,,val
US20120264734A1,Cc1[nH]c(=O)c(C#N)c(C)c1Br>>Cc1[nH]c(=O)c(CN)c(C)c1Br,,CO,,Cl,[BH4-].[Na+],val
US06538002B1,CC(=O)OC(C)=O.OC1(CCCc2ccccc2)CCN(CC2CC(NC3CCCCC3)CC2c2ccccc2)CC1>>CC(=O)N(C1CCCCC1)C1CC(CN2CCC(O)(CCCc3ccccc3)CC2)C(c2ccccc2)C1,,ClCCl,,c1ccncc1,,val
US20070037802A1,O=[N+]([O-])c1c(CS(=O)(=O)c2cccc3ccccc23)cc(F)cc1OCCCl>>Nc1c(CS(=O)(=O)c2cccc3ccccc23)cc(F)cc1OCCCl,[Pd],CCO,,NN,O,val
US20080045561A1,COc1cc2c(nc1OC)c(-c1cc3cccnc3n1S(=O)(=O)c1ccc(C)cc1)cn2CCN1CCN(C)CC1>>COc1cc2c(nc1OC)c(-c1cc3cccnc3[nH]1)cn2CCN1CCN(C)CC1,,[K+],[OH-],CO,,val
US20030236297A1,CCOC(=O)CP(=O)(OCC)OCC.O=Cc1ccc(F)cc1>>CCOC(=O)C=Cc1ccc(F)cc1,,C1CCOC1,,[H-].[Na+],,val
US20070149460A1,NCC(=O)N1C[C@H](NC(=O)c2ccccc2)C[C@H]1C(=O)O.O=CO>>O=CNCC(=O)N1C[C@H](NC(=O)c2ccccc2)C[C@H]1C(=O)O,,O=CO,,CC(=O)OC(C)=O,,val
US06045720,CCOCCCCCC(=O)C(F)(F)F>>CCOCCCCCC(O)C(F)(F)F,,CCO,,O,[BH4-].[Na+],val
US20110190490A1,CCCOc1nc(Cc2ccc(Cl)cc2)nc2oc(-c3cc(C)c(OCC(=O)OC(C)(C)C)c(C)c3)nc12>>CCCOc1nc(Cc2ccc(Cl)cc2)nc2oc(-c3cc(C)c(OCC(=O)O)c(C)c3)nc12,,O=C(O)C(F)(F)F,,O,,val
US20130150339A1,COC=C1C(=O)OC(C)(C)OC1=O.Nc1cc(Cl)nc(Cl)c1>>Oc1ccnc2cc(Cl)nc(Cl)c12,,CC(C)O,,,,val
US05614548,CCCCCCCCCCCCCCCCSCC(CO)OC.CS(=O)(=O)Cl>>CCCCCCCCCCCCCCCCSCC(COS(C)(=O)=O)OC,,ClCCl,,CCN(CC)CC,,val
US20150099719A1,COC(=O)[C@@H]1CC(=O)CC[C@H]1C(=O)OC.OCCO>>COC(=O)[C@@H]1CC2(CC[C@H]1C(=O)OC)OCCO2,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,,,val
US20040058965A1,COC(=O)Cc1ccccc1O.Cc1oc(-c2ccccc2)nc1COc1cccc(CCl)c1>>COC(=O)Cc1ccccc1OCc1cccc(OCc2nc(-c3ccccc3)oc2C)c1,,O,,CN(C)C=O,[H-].[Na+],val
US20100256097A1,Cn1cc(N)cn1.O=C(O)Cc1cccc(Br)n1>>Cn1cc(NC(=O)Cc2cccc(Br)n2)cn1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US05331005,CCOC=Nc1ccccc1.CNS(=O)(=O)Cc1ccc2[nH]cc(CCN)c2c1>>CNS(=O)(=O)Cc1ccc2[nH]cc(CCN=CNc3ccccc3)c2c1,,CC(C)=O,,,,val
US20160221945A1,COC(=O)c1cnc(-c2ccc(C(F)(F)F)nc2)cc1CNC(=O)[C@H]1C[C@H](F)CN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1C[C@@H](F)C[C@@H]1C(=O)NCc1cc(-c2ccc(C(F)(F)F)nc2)ncc1C(=O)O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20130022587A1,C[C@@H]1CCC(=O)N(C(=O)OCc2ccccc2)C1.C[C@@H]1CC[C@@H](n2cnc(C=O)c2)CC1>>C[C@@H]1CC[C@@H](n2cnc(/C=C3\C[C@@H](C)CNC3=O)c2)CC1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US04389403,Cc1ncc(C(=O)O)s1.Clc1cccc(Cl)c1NC1=NCCN1>>Cc1ncc(C(=O)N2CCN=C2Nc2c(Cl)cccc2Cl)s1,,C1CCOC1,CS(C)=O,,,val
US20060148858A1,CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCCO.CCOC(=O)CCc1cc(O)nn1C>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCCOc1cc(CCC(=O)O)n(C)n1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US03998879,CC(C)C1CC(=O)CC(=O)C1.O=C=NS(=O)(=O)c1ccc(Cl)cc1>>CC(C)C1CC(=O)C(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)C(=O)C1,,c1ccccc1,,,,val
US20050096306A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cn1ncc(NC(=O)[C@H](CCNC(=O)OC(C)(C)C)NC(=O)OCc2ccccc2)c1NC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cn1ncc(NC(=O)[C@H](CCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)c1NC(c1ccccc1)(c1ccccc1)c1ccccc1,[Pd],C1CCOC1,,,,val
US20150141406A1,O=S(=O)(OC1=CCN(Cc2ccccc2)CC1(F)F)C(F)(F)F.OB(O)c1ccc(O)cc1>>Oc1ccc(C2=CCN(Cc3ccccc3)CC2(F)F)cc1,,CC(=O)O,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],val
US20080021032A1,CN(C)CCCN.CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(Cc3ccc(C(=O)O)cc3)n2)cc1Cl>>CN(C)CCCNC(=O)c1ccc(Cn2ccc(NC(=O)[C@H](CC3CCCC3)c3ccc(S(C)(=O)=O)c(Cl)c3)n2)cc1,,ClCCl,,Cc1cccc(C)n1,O=C(Cl)C(=O)Cl,val
US08519070B2,COCCl.Oc1ccc2ccccc2c1>>COCOc1ccc2ccccc2c1,,CN(C)C=O,O,[H-].[Na+],,val
US20070105877A1,COC(=O)c1n[nH]c(C(=O)OC)c1[N+](=O)[O-].COS(=O)(=O)OC>>COC(=O)c1nn(C)c(C(=O)OC)c1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030220335A1,CCCC(=O)CC(=O)OCC.N.O=C1C=CC(=O)C=C1>>CCCc1[nH]c2ccc(O)cc2c1C(=O)OCC,,CO,,CC(=O)O,,val
US20060052374A1,[N-]=[N+]=NCc1cccnc1N1CCOCC1>>NCc1cccnc1N1CCOCC1,[Pd],CO,,,,val
US20100249094A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)ccc3C)cc12.NC1(c2cccnn2)CC1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5cccnn5)CC4)ccc3C)cc12,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20060040999A1,COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1C#N.O>>COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1C(N)=O,,CC(C)O,O,[K+].[OH-],,val
US20070135501A1,CCCCCCCOc1ccc(CC[C@](C)(C=O)NC(=O)OC(C)(C)C)cc1.CCOC(=O)CP(=O)(OCC)OCC>>CCCCCCCOc1ccc(CC[C@](C)(/C=C/C(=O)OCC)NC(=O)OC(C)(C)C)cc1,,C1CCOC1,CCOC(C)=O,[Li]CCCC,O=C([O-])O.[Na+],val
US20110312952A1,Brc1nnc(-c2nnn[nH]2)s1.CCOC(=O)CBr>>CCOC(=O)Cn1nnc(-c2nnc(Br)s2)n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140045823A1,N#Cc1ccc(C=NO)cc1F.O=C1CCC(=O)N1Cl>>N#Cc1ccc(C(Cl)=NO)cc1F,,CN(C)C=O,,,,val
US06844347B1,C1COCCN1.CC(C)c1cc(Cl)nc(-c2ccc(Cl)cc2)n1>>CC(C)c1cc(N2CCOCC2)nc(-c2ccc(Cl)cc2)n1,,O,,,,val
US20150210630A1,CCON=C(CNC(=O)c1ccccc1C(F)(F)F)c1ncc(Cl)cc1Cl>>CCO/N=C(/CNC(=O)c1ccccc1C(F)(F)F)c1ncc(Cl)cc1Cl,,CC#N,,,,val
US20100056491A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNC1CCN(c2c[nH]c3cccnc23)CC1>>CN(C(=O)OC(C)(C)C)C1CCN(c2c[nH]c3cccnc23)CC1,,ClCCl,,CCN(CC)CC,,val
US20150119362A1,COC(=O)c1ccc(Nc2cc(-c3cccc(Cl)c3)nc3c2CCC3)cc1>>OCc1ccc(Nc2cc(-c3cccc(Cl)c3)nc3c2CCC3)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130045942A1,CC(=O)C(O)[C@H]1O[C@@H](N2CN=C3C2=NC=NC3(N)Br)C[C@@]1(O)C(C)=O.NCc1ccccc1O>>CC(=O)C(O)[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4O)ncnc32)C[C@@]1(O)C(C)=O,,CCO,,CCN(CC)CC,Cl,val
US20060069255A1,O=C=Nc1cccc(Br)c1.Oc1n[nH]c2cc(Cl)ccc12.c1ccncc1>>O=C(Nc1ccc2ccccc2c1)n1nc(O)c2ccc(Cl)cc21,,CCOC(C)=O,c1ccncc1,,,val
US20130165440A1,CC(C)OB(OC(C)C)OC(C)C.Cc1cc(-c2ccc(Br)cc2)n[nH]1>>Cc1cc(-c2ccc(B(O)O)cc2)n[nH]1,,C1CCOC1,,[Li]CCCC,,val
US06207678B1,CS(=O)(=O)Cl.OCC(CC1OCCO1)c1ccc(Cl)c(Cl)c1>>CS(=O)(=O)OCC(CC1OCCO1)c1ccc(Cl)c(Cl)c1,,ClCCl,,CCN(CC)CC,,val
US20040214832A1,COc1ccccc1COCCCOc1ccc(N2C(=O)CN(C(=O)OC(C)(C)C)C[C@@H]2CO)cc1.Oc1ccc2ccccc2c1>>CC(C)(C)OC(=O)N1CC(=O)NC(COc2ccc3ccccc3c2)C1,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060173043A1,C=CCCN(Cc1ccc(OC)cc1OC)C(=O)C(=C)CCC(=O)OC>>COC(=O)CCC1=CCCCN(Cc2ccccc2)C1=O,[Ru],ClCCl,,,,val
US20070072853A1,CN(c1ccc(F)c([N+](=O)[O-])c1)S(=O)(=O)c1ccccc1.NCc1ccncc1>>CN(c1ccc(NCc2ccncc2)c([N+](=O)[O-])c1)S(=O)(=O)c1ccccc1,,CC#N,,,,val
US05296487,Cc1ccc(C2=CCNCC2)cc1.O=C1c2ccccc2C(=O)N1CCCCBr>>Cc1ccc(C2=CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)cc1,,CC#N,,CCN(CC)CC,Cl,val
US20130165422A1,CC(C)(C)OC(=O)N1CCC(CCN)CC1.NC(=O)c1cnc(Cl)cn1>>CC(C)(C)OC(=O)N1CCC(CCNc2cnc(C(N)=O)cn2)CC1,,CS(C)=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20030105078A1,O=Cc1ccc(OCc2ccccc2)c(Br)c1>>OCc1ccc(OCc2ccccc2)c(Br)c1,,C1CCOC1,,[BH4-].[Na+],[Cl-].[NH4+],val
US20060173018A1,CCCCC(O)C(=O)O.Oc1ccccc1-c1nc(N2CCNCC2)c2ccccc2n1>>CCC(C)(O)C(=O)N1CCN(c2nc(-c3ccccc3O)nc3ccccc23)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130085142A1,Clc1ccc(O[C@@H]2C[C@H]3CNCCN3C2)nc1.O=C(Cl)c1cccc(C(F)(F)F)c1>>O=C(c1cccc(C(F)(F)F)c1)N1CCN2C[C@H](Oc3ccc(Cl)cn3)C[C@H]2C1,,ClCCl,,CCN(CC)CC,,val
US06413974B1,Clc1nc(Cl)c2ncn(C3CCCC3)c2n1.NCCCCN>>NCCCCNc1nc(Cl)nc2c1ncn2C1CCCC1,,CCN(CC)CC,,,,val
US20120225888A1,COC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc(-c3cccc(Cl)c3)nn2c1C(C)C>>Cc1nc2cc(-c3cccc(Cl)c3)nn2c(C(C)C)c1[C@H](OC(C)(C)C)C(=O)O,,CO,,Cl,[Na+].[OH-],val
US08080566B1,CN(C)C=O.c1ccc(Cn2c3ccccc3c3ccccc32)cc1>>O=Cc1ccc2c(c1)c1ccccc1n2Cc1ccccc1,,CCOC(C)=O,,O=P(Cl)(Cl)Cl,,val
US20100041713A1,CC(C)(C)OC(=O)COc1c(F)c(Cl)cc2c1CCCC2NS(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C(O)COc1c(F)c(Cl)cc2c1CCCC2NS(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,C1CCOC1,,CO,[Li+].[OH-],val
US05807854,C[C@@H](n1cnc2cc(F)ccc2c1=O)[C@](O)(Cn1cncn1)c1ccc(F)cc1F.OCC(F)(F)C(F)F>>C[C@@H](n1cnc2cc(OCC(F)(F)C(F)F)ccc2c1=O)[C@](O)(Cn1cncn1)c1ccc(F)cc1F,,CCOC(C)=O,CN1CCCC1=O,O,[H-].[Na+],val
US20100144717A1,CO[C@H]1CN(CCn2c(=O)ccc3ccc(C#N)cc32)CC[C@H]1NC(=O)OC(C)(C)C>>CO[C@H]1CN(CCn2c(=O)ccc3ccc(C#N)cc32)CC[C@H]1N,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080132496A1,Cc1cc(C(=O)N[C@@H](CCNC(=O)NCCCl)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1>>Cc1cc(C(=O)N[C@@H](CCN2CCNC2=O)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20160237090A1,C[C@H](N)[C@H](C)n1cc(Br)cn1.O=Cc1ccccc1>>C[C@H](NCc1ccccc1)[C@H](C)n1cc(Br)cn1,,CO,,O,[BH4-].[Na+],val
US05459151,CCOC(=O)C(=O)N1CCC(c2ccc(OC)c(OC3CCCC3)c2)CC1.NO>>COc1ccc(C2CCN(C(=O)C(=O)NO)CC2)cc1OC1CCCC1,,CO,,Cl,[K+].[OH-],val
US20130017194A1,C#Cc1ccccc1CC(=O)OC.CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(Cl)n3)cc2)CC1>>COC(=O)Cc1ccccc1C#Cc1nc(Nc2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2)ncc1C(F)(F)F,[Cu]I,CN(C)C=O,,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130131017A1,CC1(C)OB(O)c2cc(/C=N/O)ccc21>>CC1(C)OB(O)c2cc(CN)ccc21,[Zn],CC(=O)O,,CO,,val
US06177587B1,COC(=O)c1cccc([N+](=O)[O-])c1N(Cc1ccc(-c2ccccc2C#N)cc1)C(=O)OC(C)(C)C>>COC(=O)c1cccc([N+](=O)[O-])c1NCc1ccc(-c2ccccc2C#N)cc1,,CO,,Cl,,val
US05202356,BrC(Br)(Br)Br.CCOC(=O)c1ccc(C=O)cc1>>CCOC(=O)c1ccc(C=C(Br)Br)cc1,,ClCCl,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100190747A1,CCI.O=c1c2cc[nH]c2[nH]c(=S)n1-c1ccc(OCC(F)F)cc1>>CCSc1nc2[nH]ccc2c(=O)n1-c1ccc(OCC(F)F)cc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US05840751,CC(C)c1ccccc1S.O=C(O)CCCCC1(c2ccccc2)CC(O)=C(Br)C(=O)O1>>CC(C)c1ccccc1SC1=C(O)CC(CCCCC(=O)O)(c2ccccc2)OC1=O,,ClCCl,,C1CCNCC1,,val
US20080132528A1,CSc1ncc2cc(-c3cc(C(N)=O)ccc3C)c(=O)n(C)c2n1>>CSc1ncc2cc(-c3cc(C#N)ccc3C)c(=O)n(C)c2n1,,O=S(Cl)Cl,,,,val
US20120202794A1,C=C[C@@H](CN[C@@H](CC(C)C)C(=O)OC)NC(=O)OCC1c2ccccc2-c2ccccc21>>C=C[C@H]1CN[C@@H](CC(C)C)C(=O)N1,,CCO,,CCNCC,,val
US06331553B1,CC(C)(C)OC(=O)N(Cc1cccc(N)c1)C(=O)OC(C)(C)C.O=C(O)c1ccc(Cl)nc1Cl>>CC(C)(C)OC(=O)NCc1cccc(Nc2nc(Cl)ccc2C(=O)O)c1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US04457943,NC(=O)c1ccccc1Cl.O=C=Nc1cc(Cl)c(F)c(Cl)c1F>>O=C(NC(=O)c1ccccc1Cl)Nc1cc(Cl)c(F)c(Cl)c1F,,Cc1ccccc1C,,,,val
US04886794,CN1CCC(CCCl)OC1=O.O=C([O-])C(=O)[O-].OC(c1ccc(F)cc1)(c1ccc(F)cc1)C1CCNCC1>>CN1CCC(CCN2CCC(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)CC2)OC1=O.O=C(O)C(=O)O,,CCCCO,,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20040180891A1,CCOS(=O)(=O)OCC.O=C1CC(c2ccccc2)=NN1CCO>>CCOc1cc(-c2ccccc2)nn1CCO,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090170921A1,C=Cc1c(Cc2ccccc2)cc(OC)c2c1nc(-c1ccc(C(C)C)cc1)n2CCOC>>CCc1c(Cc2ccccc2)cc(OC)c2c1nc(-c1ccc(C(C)C)cc1)n2CCOC,[Ni],CO,,,,val
US20090176794A1,CNc1cccnc1.O=C(Nn1ccc2ccccc21)Oc1ccccc1>>CN(C(=O)Nn1ccc2ccccc21)c1cccnc1,,Cc1ccccc1,,,,val
US20120316151A1,CC(C)(O)CCl.O=C(C1CC1)N1CC[C@@H](Cc2n[nH]c(=O)n2-c2ccc(-c3ccc4occc4c3)cc2)C1>>CC(C)(O)Cn1nc(C[C@@H]2CCN(C(=O)C3CC3)C2)n(-c2ccc(-c3ccc4occc4c3)cc2)c1=O,,CN(C)C=O,O,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20060094743A1,N.O=c1occ(-c2ccncc2)c2ccccc12>>O=c1[nH]cc(-c2ccncc2)c2ccccc12,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090111820A1,CO.O=C(O)c1cc[nH]c(=O)n1>>COC(=O)c1cc[nH]c(=O)n1,,CO,,C[Si](C)(C)Cl,,val
US20020022624A1,C=CC(=O)N1CCN(c2ccccc2OC)CC1.Fc1ccc(-c2cc3ccc(Cl)cc3[nH]2)cc1>>COc1ccccc1N1CCN(C(=O)CCn2c(-c3ccc(F)cc3)cc3ccc(Cl)cc32)CC1,,CN(C)C=O,O,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20060235037A1,COc1ccc(F)cc1-c1[nH]c2ccc(C3CCN(CCN(C)C(=O)OC(C)(C)C)CC3)cc2c1F>>CNCCN1CCC(c2ccc3[nH]c(-c4cc(F)ccc4OC)c(F)c3c2)CC1,,CC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20120101127A1,CC(C)(N)C(=O)O.COC(=O)c1cccc2c1NC(c1cccc(Br)c1)CC2(C)C>>CC(C)(Nc1cccc(C2CC(C)(C)c3cccc(C(=O)O)c3N2)c1)C(=O)O,[Cu]I,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120142647A1,CC(C)ONC(=O)OCc1ccccc1.CI>>CC(C)ON(C)C(=O)OCc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140213571A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N)c(-c3ccc4c(n3)-c3cc5c(F)cccc5n3CO4)cc12.CS(=O)(=O)Cl>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(NS(C)(=O)=O)c(-c3ccc4c(n3)-c3cc5c(F)cccc5n3CO4)cc12,,ClCCl,,c1ccncc1,,val
US05616537,CCOC(=O)c1c(C)[nH]c2ccc(Oc3nc(OC)cc(OC)n3)c(C(=O)OCc3ccccc3)c12.O=C(Cl)c1ccccc1>>CCOC(=O)c1c(C)n(C(=O)c2ccccc2)c2ccc(Oc3nc(OC)cc(OC)n3)c(C(=O)OCc3ccccc3)c12,,C1CCOC1,,[H-].[Na+],,val
US20120059037A1,O=C(Cl)Cc1cc(F)cc(F)c1.O=[N+]([O-])c1ccc(NCc2ccc(Cl)nc2)nc1N1CCCC1>>O=C(Cc1cc(F)cc(F)c1)Nc1ccc(NCc2ccc(Cl)nc2)nc1N1CCCC1,[Ni],C1CCOC1,,NN,,val
US04005099,Cc1nc(CN(C)C)n(-c2ccccc2C(=O)c2ccccc2Cl)c1CN1C(=O)c2ccccc2C1=O>>Cc1nc(CN(C)C)n2c1CN=C(c1ccccc1Cl)c1ccccc1-2,,CCO,,NN,O,val
US20090062223A1,C(=NC1CCCCC1)=NC1CCCCC1.CC(=O)O.CC1(O)C(OC(=O)CCN2CCOCC2)C(CO)OC1n1cc2c(N)cc3c(=O)[nH]ncc(n1)c23.CN(C)C=O>>CC(=O)OCC1OC(n2cc3c(N)cc4c(=O)[nH]ncc(n2)c34)C(C)(OC(C)=O)C1OC(=O)CCN1CCOCC1,CN(C)c1ccncc1,,,,,val
US20120010163A1,Br[Mg]c1ccccc1.COC(=O)c1c(C)cc2c(c1O)[C@]1(O)C(=O)c3cc4c(c(O)c3C(=O)[C@]1(OC)[C@H](O)C2)C(=O)C=C(N[C@H]1O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]1OC)C4=O>>COC(=O)c1c(C)cc2c(c1O)[C@]1(O)C(=O)c3cc4c(c(O)c3C(=O)[C@]1(OC)[C@H](O)C2)C(=O)C=C(N[C@H]1O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]1OC)C4(O)c1ccccc1,,C1CCOC1,,,,val
US20030087901A1,CS(=O)(=O)Cl.Oc1ccc2c(c1)CCN(c1ccc(F)cc1)C2Cc1ccc(OCCC2CCCCN2)cc1>>CS(=O)(=O)Oc1ccc2c(c1)CCN(c1ccc(F)cc1)C2Cc1ccc(OCCC2CCCCN2)cc1,,c1ccncc1,,,,val
US20070259879A1,C[C@@H]1CNCCN1.O=C(O)CSC(=S)c1ccccc1>>C[C@@H]1CN(C(=S)c2ccccc2)CCN1,,O,,[Na+].[OH-],,val
US04368205,OC1CCc2c(-c3cccs3)cccc21>>C1=Cc2cccc(-c3cccs3)c2C1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20040209873A1,Cc1cccc(CO[C@@H]2CCC[C@H](OCCNCCCc3ccccc3)C2)c1C(=O)O.O=C=Nc1ccccc1>>Cc1cccc(CO[C@@H]2CCC[C@H](OCCN(CCCc3ccccc3)C(=O)Nc3ccccc3)C2)c1C(=O)O,,CN(C)C=O,,,,val
US05312914,COC(=O)[C@@H]1[C@@H](C)OC(=O)[C@H]1NC(C)=O>>C[C@H]1OC(=O)[C@@H](N)[C@@H]1C(=O)O,,Cl,,,,val
US05625071,NS(=O)(=O)c1ncccc1F.OCCF>>NS(=O)(=O)c1ncccc1OCCF,,C1CCOC1,,[H-].[Na+],,val
US20120157428A1,Cc1noc2c1-c1ccccc1C(c1ccc(Cl)cc1)=NC2C#N.O=C(O)C(F)(F)F>>Cc1noc2c1-c1ccccc1C(c1ccc(Cl)cc1)=NC2C(N)=O,,O,,Cl,,val
US20040014776A1,Cc1ncc(C(=O)C=CN(C)C)[nH]1.N=C(N)Nc1cccc(Cl)c1>>Cc1ncc(-c2ccnc(Nc3cccc(Cl)c3)n2)[nH]1,,CCCCO,,[H-].[Na+],,val
US20070155839A1,C/C(=C\c1ccc(C(=C2CC(C)(C)OC(C)(C)C2)c2ccc(O)cc2)cc1)C(=O)OC(C)(C)C>>C/C(=C\c1ccc(C(=C2CC(C)(C)OC(C)(C)C2)c2ccc(O)cc2)cc1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020002190A1,COC(=O)Cc1ccc(N2CCOCC2)cc1.ICC1CCCC1>>COC(=O)C(CC1CCCC1)c1ccc(N2CCOCC2)cc1,,C1CCOC1,CN1CCCN(C)C1=O,CC(C)NC(C)C,[Li]CCCC,val
US20120214990A1,Cc1cc(=O)n(CC2OCCO2)c2cc(-n3ccnc3)ccc12>>Cc1cc(=O)n(CC=O)c2cc(-n3ccnc3)ccc12,,CCOC(C)=O,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US04666936,CCOC(=O)C(CC)Cc1ccc(N)cc1.O=C1OC(=O)c2ccccc21>>CCOC(=O)C(CC)Cc1ccc(N2C(=O)c3ccccc3C2=O)cc1,,O,,,,val
US20080194617A1,CC(C)(C)OC(=O)N1CCNC(=O)C1.Cc1nn(C)c(-n2ccc3cc(Cl)ccc32)c1CCOS(C)(=O)=O>>Cc1nn(C)c(-n2ccc3cc(Cl)ccc32)c1CCN1CCN(C(=O)OC(C)(C)C)CC1=O,,CN(C)C=O,,O,[H-].[Na+],val
US07179911B2,CC(=O)OCC#CCOc1ccccc1.O=S(=O)(O)Cl>>CC(=O)OCC#CCOc1ccc(S(=O)(=O)Cl)cc1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20110021491A1,CC(C)OC(=O)Cl.CS(=O)(=O)c1ccc2c(c1)CCN2c1cc(OC2CCNCC2)ncn1>>CC(C)OC(=O)N1CCC(Oc2cc(N3CCc4cc(S(C)(=O)=O)ccc43)ncn2)CC1,,ClCCl,,CCN(CC)CC,,val
US04749703,Cc1ccc2c(c1)C(NC(=O)CCCCl)c1ccccc1CS2(=O)=O.Fc1ccc(N2CCNCC2)cc1>>Cc1ccc2c(c1)C(NC(=O)CCCN1CCN(c3ccc(F)cc3)CC1)c1ccccc1CS2(=O)=O,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20060111375A1,COc1cc2c(Oc3cc4ccccc4nc3C)ccnc2cc1O.OCCBr>>COc1cc2c(Oc3cc4ccccc4nc3C)ccnc2cc1OCCO,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150126513A1,COc1ccc(C(=O)C2CCN(C3CCNC3=O)CC2)cc1.O=c1[nH]c(CCl)nc2ccsc12>>COc1ccc(C(=O)C2CCN(C3CCN(CC4=NC5C=CSC5C(=O)N4)C3=O)CC2)cc1,,C1CCOC1,CCOCC,[H-].[Na+],,val
US20040133008A1,COC(=O)c1ccc(C)cc1N1CCCC1>>Cc1ccc(C(=O)O)c(N2CCCC2)c1,,CO,O,[Na+].[OH-],,val
US20150274664A1,CC(C)(C)OC(=O)N1CCC([C@H]2C[C@@H]2COCc2ccc(S(C)(=O)=O)cn2)CC1.Cl>>CS(=O)(=O)c1ccc(COC[C@H]2C[C@@H]2C2CCNCC2)nc1.Cl,,ClCCl,,C1COCCO1,,val
US20150274750A1,CC(C)(C)OC(=O)N1CCC(C(CNS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c2ccc(C(F)(F)F)cc2)CC1>>O=[N+]([O-])c1ccc(S(=O)(=O)NCC(c2ccc(C(F)(F)F)cc2)C2CCNCC2)cc1,,C1COCCO1,CO,Cl,,val
US20150218141A1,CC(C)(C)OC(=O)OC(C)(C)C.Oc1cc(C2CCCNC2)ccc1F>>CC(C)(C)OC(=O)N1CCCC(c2ccc(F)c(O)c2)C1,,C1CCOC1,ClCCl,CCN(CC)CC,Cl,val
US20070066617A1,Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)NO.NCC(F)(F)F.O=C(c1ncc[nH]1)c1ncc[nH]1>>Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)NOC(=O)NCC(F)(F)F,,C1CCOC1,,,,val
US20050054024A1,COCCOCOc1cc2c(cc1F)C(O)(c1ccc(N(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)c(O)c1)c1cc(F)c(OCOCCOC)cc1O2.O=C(CBr)OCc1ccccc1>>COCCOCOc1cc2c(cc1F)C(O)(c1ccc(N(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)c(OCC(=O)OCc3ccccc3)c1)c1cc(F)c(OCOCCOC)cc1O2,,CN(C)C=O,,[H-].[Na+],,val
US20100305096A1,Cn1c(C=O)nc2c(N3CCOCC3)nc(Cl)nc21.O=S1(=O)CCN(C2CNC2)CC1>>Cn1c(CN2CC(N3CCS(=O)(=O)CC3)C2)nc2c(N3CCOCC3)nc(Cl)nc21,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080064696A1,Clc1ncc(Br)c(Cl)n1.O=S(=O)([O-])CCS>>CSc1nc(Cl)ncc1Br,,CC#N,,O,,val
US20080132496A1,COC(=O)Cc1nc2cc(Cl)ccc2[nH]1.Cl>>Cl.O=C(O)Cc1nc2cc(Cl)ccc2[nH]1,,Cl,,,,val
US20110028450A1,CCOC(=O)C(=O)N(CCCC#Cc1cccs1)C(C)(C)C>>CC(C)(C)N(CCCC#Cc1cccs1)C(=O)C(=O)O,,C1COCCO1,O,Cl,[K+].[OH-],val
US04013774,CC1(C)Cc2cccc(O)c2O1.O=C(Cl)Cl>>CC1(C)Cc2cccc(OC(=O)Cl)c2O1,,c1ccccc1,,c1ccncc1,,val
US20110015157A1,C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O.N#Cc1ccc(Br)nc1>>C[C@@H](c1ccc(-c2ccc(C#N)cn2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100249119A1,CC(C)(C)Oc1cccc(C(=O)O)c1.Cc1ccc(N)cc1Oc1ccc2nc(NC(=O)C3CC3)sc2n1>>Cc1ccc(NC(=O)c2cccc(OC(C)(C)C)c2)cc1Oc1ccc2nc(NC(=O)C3CC3)sc2n1,,c1ccncc1,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20150080412A1,NN.O=C(O)CCCc1ccc(Br)cc1>>NNC(=O)CCCc1ccc(Br)cc1,,C1CCOC1,,O,O=C(n1ccnc1)n1ccnc1,val
US20120202785A1,C[C@H](Nc1nc(N)nc(Cl)n1)c1nc2ccc(F)cc2n1-c1ccccc1.N>>C[C@H](Nc1nc(N)nc(N)n1)c1nc2ccc(F)cc2n1-c1ccccc1,,C1COCCO1,,,,val
US20150045339A1,CC(C)(C)OC(=O)NCCCNc1ncccc1[N+](=O)[O-].Cl>>Cl.NCCCNc1ncccc1[N+](=O)[O-],,C1COCCO1,O,CC(C)OC(C)C,,val
US06268391B1,CCOP(=O)(C#N)OCC.CN(C)C=O.O=C1Nc2ccc(C(=O)O)cc2C1=Cc1cc(Br)c(O)c(Br)c1>>O=C1Nc2ccc(C(=O)NCCO)cc2C1=Cc1cc(Br)c(O)c(Br)c1,,CN(C)C=O,,CCN(CC)CC,,val
US20090105219A1,CCOC(=O)CN1CC(CC(=O)OC)c2c1cccc2[N+](=O)[O-]>>CCOC(=O)CN1CC(CC(=O)OC)c2c(N)cccc21,[Pd],CCO,,,,val
US20050192232A1,CCCCCCCCCCC[C@H](CC(=O)N[C@H](CCCNC(=O)OCc1ccccc1)COC1CCCCO1)OCc1ccccc1>>CCCCCCCCCCC[C@H](CC(=O)N[C@H](CCCN)COC1CCCCO1)OCc1ccccc1,[Pd],CCO,,CCN(CC)CC,[H][H],val
US20150183824A1,O=C(O)CCl.OCc1ccccc1>>O=C(O)COCc1ccccc1,,C1CCOC1,COC(C)(C)C,O,[K+].[OH-],val
US20130053366A1,Cc1ccc2c(c1)c1c(n2CC2(c3cccnc3)CO2)CCN(C)C1.O=C(O)C(F)(F)F>>Cc1ccc2c(c1)c1c(n2CC(O)(CO)c2cccnc2)CCN(C)C1,,O=C(O)C(F)(F)F,,O=C([O-])O.[Na+],,val
US20070208166A1,O=C(NCC1COc2ccccc2O1)c1ccc(Nc2ccccc2C(=O)O)c([N+](=O)[O-])c1>>Nc1cc(C(=O)NCC2COc3ccccc3O2)ccc1Nc1ccccc1C(=O)O,[Pd],CO,,[BH4-].[Na+],,val
US08541595B2,BrCc1ccccc1.Brc1ccc(C2c3ccccc3-c3nccn32)cc1>>Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1,,C1CCCCC1,C1CCOC1,,,val
US05552427,COc1ccc(C=O)cc1.Cl.Cn1ccnc1N>>COc1ccc(C=Nc2nccn2C)cc1.Cl,,CCO,,C[O-].[Na+],,val
US20100056587A1,CS(=O)(=O)c1ccc(C(=O)O)s1>>CS(=O)(=O)c1ccc(CO)s1,,C1CCOC1,,B,,val
US20140134540A1,CC(CO)(CO)CO.COC(C)(C)OC>>CC1(CO)COC(C)(C)OC1,,CC(C)=O,,O=S(=O)(O)O,,val
US20100113782A1,Nc1ccc(Br)cc1F.OB(O)c1ccc(F)cc1F>>Nc1ccc(-c2ccc(F)cc2F)cc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US05420343,COC(=O)CS[C@@H]1CCC[C@H]1CCc1cc(C(C)(C)C)cc(C(C)(C)C)c1>>CC(C)(C)c1cc(CC[C@@H]2CCC[C@H]2SCC(=O)O)cc(C(C)(C)C)c1,,CO,,Cl,[Na+].[OH-],val
US20050256184A1,C=C(C)CO.Cc1ccc(S(=O)(=O)O)cc1.O=C1CCCC1.Sc1ccc(Cl)cc1>>CC1(CSc2ccc(Cl)cc2)COC2(CCCC2)OO1,,CC#N,ClCCl,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccco2)c1I.Oc1ccccc1>>Nc1nc(Oc2ccccc2)c(I)c(-c2ccco2)n1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20120149737A1,COC(=O)c1ccc(NC(=O)c2cc(Cl)c(OC(C)(C)C)c(OC(C)(C)C)c2)cc1>>CC(C)(C)Oc1cc(C(=O)Nc2ccc(C(=O)O)cc2)cc(Cl)c1OC(C)(C)C,,C1COCCO1,,,,val
US20090247567A1,COC(=O)Cl.Nc1ccc2c(c1)OCCc1cc(-c3nncn3-c3ccccc3Cl)sc1-2>>COC(=O)Nc1ccc2c(c1)OCCc1cc(-c3nncn3-c3ccccc3Cl)sc1-2,,ClCCl,,Cl,,val
US20080009530A1,BrCC1CCCO1.CCOC(=O)/C=C/c1ccc(OCCOC)cc1O>>CCOC(=O)/C=C/c1ccc(OCCOC)cc1OCC1CCCO1,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US05747517,O=C1CSC(=S)N1.O=Cc1ccc(OCc2ccccc2Cc2ccccc2)cc1>>O=C1NC(=S)SC1=Cc1ccc(OCc2ccccc2Cc2ccccc2)cc1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20100087448A1,N#Cc1cnc(Cl)s1.[Cl-].[NH4+]>>Cl.N=C(N)c1cnc(Cl)s1,,CO,,C[O-].[Na+],,val
US04824848,CCCn1c(=O)c2c(NC)n[nH]c2n(Cc2cccc(Cl)c2)c1=O.COC(=O)Cl>>CCCn1c(=O)c2c(NC)n(C(=O)OC)nc2n(Cc2cccc(Cl)c2)c1=O,,C1COCCO1,,CCN(CC)CC,,val
US04311696,CC(C)C(C(=O)OCc1ccccc1)c1ccc(N=[N+]=[N-])cc1>>CC(C)C(C(=O)O)c1ccc(N=[N+]=[N-])cc1,,O,,C1COCCO1,[Na+].[OH-],val
US20040044057A1,Nc1c(O[C@H](Cn2ccnc2)c2ccccc2)ccc2c1CCCC2=O.O=S(=O)(Cl)c1ccccc1>>O=C1CCCc2c1ccc(O[C@H](Cn1ccnc1)c1ccccc1)c2NS(=O)(=O)c1ccccc1,,ClCCl,,c1ccncc1,,val
US20140275548A1,CCOC(=O)Cc1cc2ccc(OCc3cccc(Cl)c3)cc2[nH]c1=O.O=C(Cl)C(=O)Cl>>CCOC(=O)Cc1cc2ccc(OCc3cccc(Cl)c3)cc2nc1Cl,,ClC(Cl)Cl,,CN(C)C=O,,val
US20080274892A1,CC1(C)OC(=O)N(Cc2ccccc2[N+](=O)[O-])C1O.CO>>COC1N(Cc2ccccc2[N+](=O)[O-])C(=O)OC1(C)C,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20060074119A1,COC(=O)C1(Cl)SC=CC1=O.c1ccc2[nH]cnc2c1>>COC(=O)c1sc(-n2cnc3ccccc32)cc1O,,ClC(Cl)Cl,O,CC(=O)O,,val
US20030078260A1,CC(C)(C)OC(=O)N(C[C@H]1CCc2cc([N+](=O)[O-])ccc2O1)C[C@H](O)c1cccnc1>>CC(C)(C)OC(=O)N(C[C@H]1CCc2cc(N)ccc2O1)C[C@H](O)c1cccnc1,[Pd],C1CCOC1,CCO,[BH4-].[Na+],,val
US20080058329A1,COc1ccc2c([C@@H]3C[C@@H](N=[N+]=[N-])c4ccccc43)c[nH]c2c1.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1ccc2c([C@@H]3C[C@@H](N=[N+]=[N-])c4ccccc43)cn(S(=O)(=O)c3ccc(C)cc3)c2c1,,C1CCOC1,CCOC(C)=O,O,[H-].[Na+],val
US20130059834A1,C[C@@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4c3CC(C)(C)CC4)nc12)C(=O)N1CC(C#N)C1>>C[C@@H](NC(=O)c1c[nH]c2ncc(-c3nn(C)c4c3CC(C)(C)CC4)nc12)C(=O)N1CC(C#N)C1,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US06187966B1,O=C(CCl)c1ccccc1>>O[C@H](CCl)c1ccccc1,,O,,Cl,,val
US04328244,Cc1ccc(C)c(CCl)c1.Nc1cccc(S(=O)(=O)O)c1>>Cc1ccc(C)c(CNc2cccc(S(=O)(=O)O)c2)c1,,CC#N,O,Cl,CC(=O)[O-].[Na+],val
US20080153883A1,CCCCN1CC(C)(C)SC1=N.COc1ccc(Cl)cc1C(=O)O>>CCCCN1CC(C)(C)S/C1=N\C(=O)c1cc(Cl)ccc1OC,CN(C)c1ccncc1,c1ccncc1,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20100249089A1,COc1ccc(/C(C#N)=C/c2ccc(N3CCC(OC(=O)CN4CCCCCCC4)CC3)s2)cc1OC.CS(=O)(=O)O>>COc1ccc(/C(C#N)=C/c2ccc(N3CCC(OC(=O)CN4CCCCCCC4)CC3)s2)cc1OC.CS(=O)(=O)O,,CO,,,,val
US06969731B1,C1=COCCC1.O=S(=O)(Cl)c1cccc(O)c1>>O=S(=O)(Cl)c1cccc(OC2CCCCO2)c1,,ClCCl,,CCOCC,,val
US20060293322A1,O=P(Cl)(Cl)Cl.O=c1[nH]cnc2sc3c(c12)CCC1(C3)OCCO1>>Clc1ncnc2sc3c(c12)CCC1(C3)OCCO1,,CCN(CC)CC,,,,val
US20100261755A1,CCOC(=O)CC(=O)[C@H]1CCN(C(=O)OC)[C@@H](Cc2cc(F)cc(C(F)(F)F)c2)C1.NO>>COC(=O)N1CC[C@H](c2cc(=O)[nH]o2)C[C@@H]1Cc1cc(F)cc(C(F)(F)F)c1,,CO,O,Cl,[Na+].[OH-],val
US20140288045A1,CC(C)(C)OC(=O)N1CCNCC1.COc1cc(Cl)c(-c2ccccc2Cl)cc1C(=O)O>>COc1cc(Cl)c(-c2ccccc2Cl)cc1C(=O)N1CCN(C(=O)OC(C)(C)C)CC1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20080306045A1,CC(C)(C)OC(=O)N1CCCc2cc(N3CC[C@H](N(CCO)S(=O)(=O)/C=C/c4ccc(Cl)s4)C3=O)ccc2C1.Cl>>Cl.O=C1[C@@H](N(CCO)S(=O)(=O)/C=C/c2ccc(Cl)s2)CCN1c1ccc2c(c1)CCCNC2,,C1COCCO1,Cl,,,val
US06051288,CCCCC[C@@H]1CC[C@@H](CCc2ccc(C(=O)O)c(F)c2)CC1.O=S(Cl)Cl>>CCCCC[C@@H]1CC[C@@H](CCc2ccc(C(=O)Cl)c(F)c2)CC1,,Cc1ccccc1,,c1ccncc1,,val
US20150307439A1,C#CC(C)(O)CCCC(C)CC.CC(=O)OC(C)=O>>C#CC(C)(CCCC(C)CC)OC(C)=O,,O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05120738,CC1(C)OCC(C)(C)C(C(=O)NCCC(=O)OCc2ccccc2)O1>>CC1(C)OCC(C)(C)C(C(=O)NCCC(=O)O)O1,,CO,,[Na+].[OH-],,val
US20090088457A1,Cc1cccc(CN(C(=O)C(C#N)Cc2cnc(OCCO[Si](C)(C)C(C)(C)C)s2)C2CC2)c1C>>Cc1cccc(CN(C(=O)C(CN)Cc2cnc(OCCO[Si](C)(C)C(C)(C)C)s2)C2CC2)c1C,,CO,,[BH4-].[Na+],,val
US20140163025A1,COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccc(C(=O)OCc6ccccc6)cc5)ccc(F)c43)ccc21>>COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccc(C(=O)O)cc5)ccc(F)c43)ccc21,[Pd],CCOC(C)=O,,,,val
US20040063944A1,CCO/C=C(/C(=O)Nc1ccc(C2(c3ccc(Cl)cc3)OCCO2)cc1)C(=O)OCC>>CCOC(=O)c1cnc2ccc(C3(c4ccc(Cl)cc4)OCCO3)cc2c1O,,c1ccc(Oc2ccccc2)cc1,,,,val
US05192789,CN1c2ccc(O)cc2C2CCC(N)C21.O=C(Cl)OCc1ccccc1>>CN1c2ccc(O)cc2C2CCC(NC(=O)OCc3ccccc3)C21,,ClCCl,,CCN(CC)CC,,val
US20050154042A1,CCCCN=Cc1ccccc1.O=[N+]([O-])Cc1ccc(F)cc1>>O=[N+]([O-])C(=Cc1ccccc1)c1ccc(F)cc1,,CC(=O)O,,,,val
US20100152450A1,CC(C)(C)OC(=O)N1CCC(CCO)CC1.COc1ccc(CBr)cc1>>COc1ccc(COCCC2CCNCC2)cc1,,C1CCOC1,,[H-].[Na+],,val
US20100010217A1,CC(C)(O)CN.O=[N+]([O-])c1c(Cl)nc2ccccc2c1Cl>>CC(C)(O)CNc1c([N+](=O)[O-])c(Cl)nc2ccccc12,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20080021032A1,Cc1cc([C@@H](C[C@H]2CCC(=O)C2)C(=O)Nc2ccn(CCO[Si](C)(C)C(C)(C)C)n2)ccc1S(C)(=O)=O>>Cc1cc([C@@H](C[C@H]2CCC(=O)C2)C(=O)Nc2ccn(CCO)n2)ccc1S(C)(=O)=O,Cl,CC#N,,CCO,,val
US20060025442A1,CC1(C)COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H]2C[C@H](O)C[C@H]2c2ccc(Cl)cc2)CC1.CNS(=O)(=O)c1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>CN([C@@H]1C[C@@H](C(=O)N2CCC(CN3C(=O)OCC3(C)C)(C3CCCCC3)CC2)[C@H](c2ccc(Cl)cc2)C1)S(=O)(=O)c1ccc([N+](=O)[O-])cc1[N+](=O)[O-],,c1ccccc1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110059954A1,Cc1cccc2c1OCC2.O=C(Cl)c1cc(Cl)ncn1>>Cc1cc(C(=O)c2cc(Cl)ncn2)cc2c1OCC2,,ClCCl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20090143371A1,Cc1onc(-c2cccc(Cl)c2)c1COc1ccc(C(=O)O)cn1.NCC(F)(F)F>>Cc1onc(-c2cccc(Cl)c2)c1COc1ccc(C(=O)NCC(F)(F)F)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20090264445A1,COC(=O)C(=CC1CC2CCC1C2)NC(=O)OCc1ccccc1>>COC(=O)C(N)CC1CC2CCC1C2,[Pd],CO,,[H][H],,val
US20090221702A1,CCCC(=O)Cl.Oc1ccc(CCCl)cc1>>CCCC(=O)Oc1ccc(CCCl)cc1,,ClCCl,,c1ccncc1,,val
US05840732,CCCCCCCCCC=O.O=C1COC(=O)N1CCCCSc1cccc2nccn12>>CCCCCCCCCC=C1OC(=O)N(CCCCSc2cccc3nccn23)C1=O,,CCO,,C1CCNC1,,val
US20100273755A1,C[C@H](Cc1cccc(CCNC(=O)Cc2ccc(CNC(=O)CCN3CCC(OC(=O)Nc4ccccc4-c4ccccc4)CC3)cc2)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12>>C[C@H](Cc1cccc(CCNC(=O)Cc2ccc(CNC(=O)CCN3CCC(OC(=O)Nc4ccccc4-c4ccccc4)CC3)cc2)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c2[nH]c(=O)ccc12,[Pd],CCO,,,,val
US20080096895A1,C1CNCCN1.Clc1ccc(-c2ccccc2)nn1>>c1ccc(-c2ccc(N3CCNCC3)nn2)cc1,,CC#N,,,,val
US05807887,Cc1c(F)cc2sccc2c1F.O=C1CCC(=O)N1Br>>Fc1cc2sccc2c(F)c1CBr,,ClC(Cl)(Cl)Cl,,,,val
US20120122857A1,COc1ccc(-n2nc(C(C)(C)C)cc2N)cc1.O.O=C(Cl)c1nccc2cc(Oc3cc(Cl)ncn3)ccc12.c1ccncc1>>COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)c2nccc3cc(Oc4cc(NC(C)=O)ncn4)ccc23)cc1,,ClCCl,,,,val
US20040097510A1,BrCCBr.CC(=O)c1cccc(O)c1O>>CC(=O)c1cccc2c1OCCO2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130338134A1,COc1cc(OC)c(F)c(N2Cc3cnc4c(cc(C=O)n4S(=O)(=O)c4ccccc4)c3N(C)C2=O)c1F>>COc1cc(OC)c(F)c(N2Cc3cnc4c(cc(CO)n4S(=O)(=O)c4ccccc4)c3N(C)C2=O)c1F,,C1CCOC1,,[BH4-].[Na+],,val
US20060241147A1,CC1CCC(C)N1.O=C(CCl)Nc1ccc(Oc2ccc3c(c2)CCC(c2ccccc2)O3)nc1>>CC1CCC(C)N1CC(=O)Nc1ccc(Oc2ccc3c(c2)CCC(c2ccccc2)O3)nc1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US09073882B2,CC(C)(C)OC(=O)C(C)(C(=O)[O-])c1ccc(C#N)c(F)c1Cl>>COC(=O)Cc1ccc(C#N)c(F)c1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040138277A1,CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccccc1.Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccc(-c4cccs4)cc3)oc2C)cc1>>Cc1oc(-c2ccc(-c3cccs3)cc2)nc1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1,,CCO,,,,val
US20070232583A1,CC(C)(C)O.Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(N)c3)n2)n1.O=C=NS(=O)(=O)Cl>>Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(NS(=O)(=O)NC(=O)OC(C)(C)C)c3)n2)n1,,ClCCl,ClCCl,CCN(CC)CC,,val
US20080261941A1,CC(C)(C)OC(=O)N1CCC(=Cc2cccc(Oc3ccc(C4CC4)cn3)c2)CC1.O=C(O)C(F)(F)F>>C(=C1CCNCC1)c1cccc(Oc2ccc(C3CC3)cn2)c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20150126490A1,COC(=O)Cl.Nc1ncc(C2CCNCC2)nc1Br>>COC(=O)N1CCC(c2cnc(N)c(Br)n2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05241064,C=C(C(=O)OCC)C(C)OC(C)=O>>C=C(C(=O)OCC)[C@@H](C)O,,O=P([O-])([O-])[O-],,,,val
US07612075B2,Cc1ccc(C#N)c(N)c1.N=C(c1ccccc1)c1ccccc1>>Cc1ccc(C#N)c(N=C(c2ccccc2)c2ccccc2)c1,,CC(Cl)Cl,,,,val
US20150355544A1,O=C1CCC(=O)N1Br.c1c(C2CCCCC2)cc(C2CCCCC2)cc1C1CCCCC1>>Brc1c(C2CCCCC2)cc(C2CCCCC2)cc1C1CCCCC1,,ClCCl,,CC#N,,val
US20110230459A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1NCC12CCN(Cc1ccccc1)CC2>>CC(C)(C)OC(=O)N1CC2(CCN(Cc3ccccc3)CC2)C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05521179,CC(C)C(NC(=O)Cn1c(-c2cccc(OC(C)(C)C)c2)ccc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F>>CC(C)C(NC(=O)Cn1c(-c2cccc(O)c2)ccc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110046108A1,Clc1ccnc(Cl)n1.Nc1cc(CO)cc2c1OCO2>>OCc1cc(Nc2ccnc(Cl)n2)c2c(c1)OCO2,,CCCCO,,CCN(C(C)C)C(C)C,,val
US04824468,CC(C)N=C=O.CCC1CNC(c2ccc(Cl)c(C(F)(F)F)c2)O1>>CCC1CN(C(=O)NC(C)C)C(c2ccc(Cl)c(C(F)(F)F)c2)O1,,CC(C)=O,,,,val
US04797401,CS(=O)(=O)Nc1ccc(CCOS(C)(=O)=O)cc1.Cc1cc(N2CCNCC2)ccc1NS(C)(=O)=O>>Cc1cc(N2CCN(CCc3ccc(NS(C)(=O)=O)cc3)CC2)ccc1NS(C)(=O)=O,,CCO,,,,val
US20030186969A1,COC(=O)c1cccc(CBr)c1.O=C1CN(C(=O)c2ccc(Cl)cc2)Cc2ccccc2N1>>COC(=O)c1cccc(CN2C(=O)CN(C(=O)c3ccc(Cl)cc3)Cc3ccccc32)c1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US06143764,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Nc1ccccc1O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4O)cc3)c2cc1OC,,CCN(CC)CC,Cc1ccccc1,O=C([O-])O.[Na+],,val
US20140194469A1,COC(=O)c1ccc(Br)cc1Cl.OB(O)C1CC1>>COC(=O)c1ccc(C2CC2)cc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,Cc1ccccc1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20070161648A1,CC(C)(C)OC(=O)n1c(-c2cccc3c2C(=O)NC3)cc2cc(OCc3ccccc3)ccc21>>CC(C)(C)OC(=O)n1c(-c2cccc3c2C(=O)NC3)cc2cc(O)ccc21,[Pd],C1CCOC1,CCOC(C)=O,,,val
US05312617,CCCCCCCCCCCCN.OCC1CO1>>CCCCCCCCCCCCNCC(O)CO,,CO,,,,val
US04254036,C#CCC(C)(O)CCCCl.C[Si](C)(C)Cl>>C#CCC(C)(CCCCl)O[Si](C)(C)C,,O,,CN(C)C=O,c1c[nH]cn1,val
US07723371B2,Cn1ccc(C(=O)O)c1C(F)(F)F.Nc1ccccc1C1CCC1C1CC1>>Cn1cc(C(=O)Nc2ccccc2C2CCC2C2CC2)c(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,CN(C)C=O,val
US20150329523A1,NC(=O)Oc1cccc([N+](=O)[O-])c1>>NC(=O)Oc1cccc(N)c1,[Pd],CCO,,[H][H],,val
US20010006969A1,C=CCNc1nc(Cl)nc2ccc([N+](=O)[O-])cc12.N>>C=CCNc1nc(N)nc2ccc([N+](=O)[O-])cc12,,C1CCOC1,CCO,O,,val
US20120316161A1,CCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1Cl.CN1CCc2cc(B3OC(C)(C)C(C)(C)O3)ccc21>>CCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc2c(c1)CCN2C,,COCCOC,O,CCN(C(C)C)C(C)C,,val
US20160198708A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#CCc1ncc(Br)cc1Cl>>CC(C)(C)OC(=O)NCCc1ncc(Br)cc1Cl,,CO,,[BH4-].[Na+],,val
US20090275606A1,CC1(C)OCC(CON)O1.O=C(O)c1c(Nc2ccc(I)cc2F)c(F)c(=O)n2c1CCC2>>CC1(C)OCC(CONC(=O)c2c(Nc3ccc(I)cc3F)c(F)c(=O)n3c2CCC3)O1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US05621010,CC(C)(C)c1cc(C=Cc2ccccc2[N+](=O)[O-])cc(C(C)(C)C)c1O>>CC(C)(C)c1cc(C=Cc2ccccc2N)cc(C(C)(C)C)c1O,[Fe],CO,,Cl,O,val
US05420115,Cl.Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F>>Cl.Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F,,CO,O,CC(C)O,,val
US05817774,COc1ccc(-c2cc(-c3ccccn3)nc(-c3cccc(C=O)n3)c2)cc1>>COc1ccc(-c2cc(-c3ccccn3)nc(-c3cccc(CO)n3)c2)cc1,,C1CCOC1,CCO,[BH4-].[Na+],,val
US04820719,CC(C)(C)OC(=O)CC(O)c1ccccc1CCCCCCCSc1cccc(C(F)(F)F)c1.O=C(O)CCS>>O=C(O)CCSC(CC(=O)O)c1ccccc1CCCCCCCSc1cccc(C(F)(F)F)c1,,O=C(O)C(F)(F)F,,,,val
US20120108582A1,BrC(Br)(Br)Br.C=C(CO)[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1C(=O)OC(C)(C)C>>C=C(CBr)[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1C(=O)OC(C)(C)C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150191463A1,CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CNOC.Cl.Cl>>CON(C)C(=O)c1ccc(Cl)nc1Cl,,CCOC(C)=O,,CCN(CC)CC,,val
US20120004203A1,CC(N)=O.CCOP(=O)(OCC)OCC.N#Cc1ccc(C=O)cc1.NC(=S)Nc1cccc(C(F)(F)F)c1>>CC1=C(C#N)C(c2ccc(C#N)cc2)NC(=S)N1c1cccc(C(F)(F)F)c1,,C1CCOC1,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20120028931A1,CC(C)(C)OC(=O)N1CCC(=CC(=O)Cl)CC1.NC(=NO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)N1CCC(=CC(=O)ON=C(N)c2cccc(Cl)c2)CC1,,ClC(Cl)Cl,,O,,val
US20140094462A1,CC(C)(C)OC(=O)C[C@@H]1CC=CCCC(=O)O[C@H](c2ccccc2)CNC1=O.CI>>CN1C[C@@H](c2ccccc2)OC(=O)CCC=CC[C@@H](CC(=O)OC(C)(C)C)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20060040954A1,CCOC(=O)COc1ccc(CCCCNC(=O)OCc2ccccc2)cc1>>CCOC(=O)COc1ccc(CCCCN)cc1,[Pd],CO,,[H][H],,val
US04891432,BrCCCCCBr.CC(C)(CCCCOc1ccc(O)cc1)C(N)=O>>CC(C)(CCCCOc1ccc(OCCCCCBr)cc1)C(N)=O,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US06403607B1,O=[N+]([O-])c1ccccc1F.Sc1ccc(Cl)cc1>>O=[N+]([O-])c1ccccc1Sc1ccc(Cl)cc1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US06018046,COc1cc2c3c(c1)c1cc(Br)ccc1n3CCC2=O.O=Cc1ccccn1>>COc1cc2c(=O)c(Cc3ccccn3)cn3c4ccc(Br)cc4c(c1)c23,,CCO,O,[Na+].[OH-],,val
US20140038990A1,COC(=O)C#CC(=O)OC.N#CCC1(c2ccccc2)CCCC1.NO>>COC(=O)c1nc(CC2(c3ccccc3)CCCC2)[nH]c(=O)c1O,,CO,,Cl,[K+].[OH-],val
US20160122323A1,CC(C)(C)OC(=O)Nc1ccc(C(=O)Nc2cccc(Nc3ccc(Cl)c(-c4cn(S(=O)(=O)c5ccccc5)c5ccccc45)n3)c2)cc1>>Nc1ccc(C(=O)Nc2cccc(Nc3ccc(Cl)c(-c4cn(S(=O)(=O)c5ccccc5)c5ccccc45)n3)c2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100273744A1,CCCCBr.O=C(Nc1ccn(Cc2cc(O)ccc2Cl)n1)c1c(F)cccc1F>>CCCCOc1ccc(Cl)c(Cn2ccc(NC(=O)c3c(F)cccc3F)n2)c1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20060160865A1,CC(C)(C)OC(=O)CBr.CN(C(=O)Oc1ccc(N)cn1)c1ccccc1>>CN(C(=O)Oc1ccc(NCC(=O)OC(C)(C)C)cn1)c1ccccc1,,Cc1ccccc1,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20100261762A1,CC(C)(C)OC(=O)N1CC[C@H](C(=O)C2CCC2)C1>>CC(C)(C)OC(=O)N1CC[C@H](C(O)C2CCC2)C1,,CO,,[Na],,val
US20140213580A1,CI.COCCC(=O)N1CCN(c2nc(C3CC3)c(Nc3ccnc(Cl)c3)cc2C#N)C[C@H]1C>>COCCC(=O)N1CCN(c2nc(C3CC3)c(N(C)c3ccnc(Cl)c3)cc2C#N)C[C@H]1C,,C1CCOC1,,[H-].[Na+],,val
US20100190763A1,Cc1cc(F)ccc1N.Cl.ClCCNCCCl>>Cc1cc(F)ccc1N1CCNCC1.Cl.Cl,,CC(C)O,,,,val
US20100249191A1,O=[N+]([O-])c1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1F.c1nc[nH]n1>>O=[N+]([O-])c1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1-n1cncn1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US05539112,CC(C)(C)C(=O)Cl.Nc1ccc(-c2cc(=O)c3c(N)c(F)cc(F)c3o2)cc1F>>CC(C)(C)C(=O)Nc1ccc(-c2cc(=O)c3c(N)c(F)cc(F)c3o2)cc1F,,c1ccncc1,,O,,val
US20070124152A1,CCOC(=O)c1ncc(Cc2ccc(F)cc2)cc1NC(=O)C(F)(F)F.O=S(=O)(CCCI)N1CCCC1>>CCOC(=O)c1ncc(Cc2ccc(F)cc2)cc1NCCCS(=O)(=O)N1CCCC1,,CN(C)C=O,Cc1ccccc1,O=C([O-])[O-].[Cs+].[Cs+],,val
US05912246,C=O.Clc1ccc(N2CCN(Cc3cn4cc(Cl)ccc4n3)CC2)c(Cl)c1>>OCc1c(CN2CCN(c3ccc(Cl)cc3Cl)CC2)nc2ccc(Cl)cn12,,O,,C1CCOC1,,val
US05304566,CN=C(C)NC#N.ClCc1ccc(Cl)nc1>>CN=C(C)N(C#N)Cc1ccc(Cl)nc1,,CN(C)C=O,,[H-].[Na+],,val
US20160145252A1,CC(C)N.CCOC(=O)c1cnc(Cl)nc1Cl>>CCOC(=O)c1cnc(Cl)nc1NC(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06218376B1,Cc1nc2c(=O)c3ccc(C(C)Br)cc3ccc2s1>>CCc1ccc2c(c1)C=Cc1sc(C)nc1C2O,,C1COCCO1,CS(C)=O,[BH4-].[Na+],,val
US04002620,Nc1ccc(Cl)cc1CO.S=C=S>>S=C1Nc2ccc(Cl)cc2CS1,,CCO,,[K+].[OH-],,val
US04704462,CCCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@@H]2C.CON>>CCCC1=C[C@@]2(OC)C(=CC1=NOC)O[C@H](c1ccc(OC)c(OC)c1)[C@@H]2C,,c1ccncc1,,Cl,,val
US20160046653A1,CC[SiH](CC)CC.CN1CCC(N(Cc2cccs2)c2ccccc2)CC1>>CC[Si](CC)(CC)c1ccc(CN(c2ccccc2)C2CCN(C)CC2)s1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US04166854,CC(C)(C)C(=O)CBr.Oc1cccc(Cl)n1>>CC(C)(C)C(=O)COc1cccc(Cl)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130029961A1,CNCCOC.O=[N+]([O-])c1ccc(Cl)nc1>>COCCN(C)c1ccc([N+](=O)[O-])cn1,,O,,,,val
US20150065482A1,NN.O=Cc1c(Cl)cc(Cl)nc1Cl>>Clc1cc2[nH]ncc2c(Cl)n1,,COCCOC,,O,,val
US05077409,CCCCCCCCCCCCCCOc1ccc(CC(=O)Cl)cc1.Nc1cccc(I)c1>>CCCCCCCCCCCCCCOc1ccc(CC(=O)Nc2cccc(I)c2)cc1,,C1CCOC1,,c1ccncc1,,val
US20100311799A1,COc1cc(Br)ccc1C(=O)O.O=S(Cl)Cl>>COc1cc(Br)ccc1C(=O)Cl,,ClC(Cl)Cl,,CN(C)C=O,,val
US20090156575A1,CC1(C)COc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccnc(C#N)c3)CC4)c2O1.O=C(O)C(F)(F)F.OO>>CC1(C)COc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccnc(C(N)=O)c3)CC4)c2O1.O=C(O)C(F)(F)F,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06437184B1,CCOC(COCCCCOc1c(CC)cc(OCC=C(Cl)Cl)cc1CC)OCC>>CCc1cc(OCC=C(Cl)Cl)cc(CC)c1OCCCCOCC=O,,O,,CC(=O)O,Cl,val
US03956310,CN=C=O.O=C1NC2(CCCCC2)NC12CCCCC2>>CNC(=O)N1C(=O)C2(CCCCC2)NC12CCCCC2,,c1ccccc1,,C1CN2CCN1CC2,,val
US20130157999A1,CCNc1nc(Cl)ncc1C(F)(F)F.CNC(=O)c1ccc(N)c2c1OCCO2>>CCNc1nc(Nc2ccc(C(=O)NC)c3c2OCCO3)ncc1C(F)(F)F,,CC(C)(C)O,,,,val
US20120083474A1,O=C1c2ccccc2C(=O)N1Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(Cl)n1.OB(O)c1cccnc1>>O=C1c2ccccc2C(=O)N1Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(-c2cccnc2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US05215982,CCO/C=C/n1ncc(C)c1N>>Cc1cnn2cc[nH]c12,,C1CCOC1,,CCOC(C)=O,Cl,val
US20140296225A1,COC(=O)CNCCN(C(=O)OC(C)(C)C)C1CCc2ccc(C#N)cc2C1>>N#Cc1ccc2c(c1)CC(N1CCNCC1=O)CC2,,ClCCl,O=C(O)C(F)(F)F,,,val
US20060004043A1,CCOC=CC(=O)Nc1ccc(Br)cc1>>O=c1ccc2cc(Br)ccc2[nH]1,,O=S(=O)(O)O,,,,val
US20070124152A1,CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN2CCCC2=O)c1=O.NC1CC1>>O=C(NC1CC1)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN2CCCC2=O)c1=O,,CCO,,,,val
US03968240,CCC(=O)OC(=O)CC.Cc1ccc(C(Cl)=NO)cc1>>CCC(=O)ON=C(Cl)c1ccc(C)cc1,,c1ccccc1,,,,val
US07202269B2,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCCC1.CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.NCCCN1CCCC1.On1nnc2ccccc21>>N#CNC(=Nc1ccc(-c2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCCC1,,CCOC(C)=O,CN(C)C=O,CN1CCOCC1,Cl,val
US20050080064A1,CCOC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)[C@H](CC)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C>>C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)[C@H](C)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C,,CCO,,Cl,[Na+].[OH-],val
US20110070161A1,CCNCC.COc1cccc2c1c1c(n2CCOCc2ccccc2)CCCC1C(=O)O>>CCNCC.COc1cccc2c1c1c(n2CCO)CCCC1C(=O)O,[Pd],CO,,[H][H],,val
US20110190257A1,CSc1ccc(N)c(F)c1.O=C(O)c1ccc2cnsc2c1F>>CSc1ccc(Nc2c(C(=O)O)ccc3cnsc23)c(F)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20040092533A1,CC[Si](CC)(CC)OC(C)(C)c1ccn2c(-c3ccnc(-c4ccncc4)n3)cnc2n1>>CC(C)(O)c1ccn2c(-c3ccnc(-c4ccncc4)n3)cnc2n1,Cl,,,,,val
US20130231328A1,CCC(O)C[C@H]1CCc2sc3ncnc(NC4CCC(NC(=O)OC(C)(C)C)CC4)c3c21>>CCC(O)C[C@H]1CCc2sc3ncnc(NC4CCC(N)CC4)c3c21,,ClCCl,,Cl,,val
US20030186987A1,CI.S=c1[nH]cnc2ccncc12>>CSc1ncnc2ccncc12,,CS(C)=O,,CCN(CC)CC,,val
US05364880,COC(=O)COc1ccccc1C=O>>COC(=O)c1cc2ccccc2o1,,O,,Cc1ccccc1,,val
US04921852,COC(OC)C(N)=S.CS(=O)(=O)O[C@@H]1C[C@@H](C(=O)CBr)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1>>COC(OC)c1nc([C@@H]2C[C@@H](OS(C)(=O)=O)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)cs1,,CC(=O)N(C)C,ClCCl,CCOC(C)=O,,val
US04956359,CNC.O=C(Cl)N1CC(Sc2ccc(Cl)cc2)C1>>CN(C)C(=O)N1CC(Sc2ccc(Cl)cc2)C1,,C1CCOC1,O,,,val
US20050124656A1,CCCCCCCCCCCc1noc(-c2ccc(CNCc3ccc(C(F)(F)F)cc3)cc2)n1.CCOC(=O)C(=O)Cl>>CCCCCCCCCCCc1noc(-c2ccc(CN(Cc3ccc(C(F)(F)F)cc3)C(=O)C(=O)OCC)cc2)n1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20100130506A1,CSC(=N)NC(=O)c1nc(Cl)c(N)nc1N.NC[C@@H]1CCCN1>>Nc1nc(N)c(C(=O)N=C2NCC3CCCN23)nc1Cl,,CC(C)O,,,,val
US20010041702A1,Cl.O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)O[C@H]1OCCN(Cc2ccccc2)[C@H]1c1ccc(F)cc1>>Cl.O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)O[C@H]1OCCN(Cc2ccccc2)[C@H]1c1ccc(F)cc1,,CCOCC,,,,val
US20030125332A1,N#Cc1c(-c2ccccc2)cnnc1Cl.NN>>Nc1n[nH]c2nncc(-c3ccccc3)c12,,CCO,,,,val
US20010051623A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc(N2CCNCC2)c2c1CC[C@@H](N)C2>>Cc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)c2c1CC[C@@H](N)C2,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20140336376A1,CC(=O)CSc1cc(F)c(F)cc1Br>>Cc1csc2c(Br)cc(F)c(F)c12,,Clc1ccccc1,,,,val
US20060160865A1,C1COCCN1.CN(C(=O)Oc1ccc(NC(=O)c2ccc(C=O)cc2)cn1)c1ccccc1>>CN(C(=O)Oc1ccc(NC(=O)c2ccc(CN3CCOCC3)cc2)cn1)c1ccccc1,,CO,,[BH3-]C#N.[Na+],,val
US20060257987A1,CCc1ccc(OC)c(C(=O)c2ccccn2)c1>>CCc1ccc(O)c(C(=O)c2ccccn2)c1,,CCOCC,ClCCl,,,val
US20100035895A1,CC(C)NC(C)C.C[Si](C)(C)C#N.ClCCl.O=C(Cl)c1ccccc1>>N#Cc1cccc(-c2ccccc2)n1,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US20100029650A1,COC(=O)c1nc(Br)ccc1OCC1CCN(C(=O)OC(C)C)CC1.CS(=O)(=O)c1ccc(B(O)O)cc1>>COC(=O)c1nc(-c2ccc(S(C)(=O)=O)cc2)ccc1OCC1CCN(C(=O)OC(C)C)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20130338196A1,COC(=O)OC.COc1ccc2c(c1)C(=O)CC2>>COC(=O)C1Cc2ccc(OC)cc2C1=O,,C1CCOC1,,[H-].[Na+],,val
US20030207887A1,CO.CO[Na].Clc1cccc(-c2nc(Cl)nc3ccc(Br)cc23)c1>>COc1cc(-c2cccc(Cl)c2)c2cc(Br)ccc2n1,,CO,,,,val
US20140343285A1,CCBr.C[C@@H](C=NNC=O)OCc1ccccc1>>CC[C@H](NNC=O)[C@H](C)OCc1ccccc1,,COC(C)(C)C,,II,,val
US20080207900A1,C[C@H](OC(=O)c1ccc([N+](=O)[O-])cc1)[C@H]1COC[C@@H](c2ccc(Cl)cc2)N1>>C[C@H](O)[C@H]1COC[C@@H](c2ccc(Cl)cc2)N1,,CO,,C[O-].[Na+],,val
US20120142717A1,CI.COC(=O)CCc1cc2ccccc2[nH]1>>COC(=O)CCc1cc2ccccc2n1C,,CN(C)C=O,,[H-].[Na+],,val
US20090137642A1,N#Cc1sc(N)nc1-c1ccccc1.NO>>N=C(NO)c1sc(N)nc1-c1ccccc1,,CCO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20140086837A1,O=C(O)CNC(=O)c1ccc([N+](=O)[O-])c(F)c1>>Nc1ccc(C(=O)NCC(=O)O)cc1F,[Fe],CC(=O)O,CCOC(C)=O,,,val
US20120142672A1,CC(=O)Cl.CCO.N#CC(CCCCl)c1ccc(Cl)c(Cl)c1>>CCOC(=N)C(CCCCl)c1ccc(Cl)c(Cl)c1.Cl,,CCO,,,,val
US20160068513A1,CC(C)c1cc(Nc2nc(Cl)nc3c2CCC3(C)C)[nH]n1.CO.O=C(O)[C@@H]1CCCN1>>COC(=O)C1CCCN1c1nc(Nc2cc(C(C)C)n[nH]2)c2c(n1)C(C)(C)CC2,,CO,,O=C(O)C(F)(F)F,,val
US04734437,CC(=O)CCc1ccc(OCc2ccccc2)cc1.Cl.N>>CC([NH3+])CCc1ccc(OCc2ccccc2)cc1.[Cl-],[Ni],CCO,,,,val
US20120264734A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.COC(=O)c1cc(Br)cc(N)c1C>>COC(=O)c1cc(Br)cc(NC2CCN(C(=O)OC(C)(C)C)CC2)c1C,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100093730A1,O=C1NCCC1(c1ccccc1)c1ccccc1.O=S(=O)(Cl)c1cccc(C(F)(F)F)c1>>O=C1N(S(=O)(=O)c2cccc(C(F)(F)F)c2)CCC1(c1ccccc1)c1ccccc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20090137637A1,CCOC(=O)C1CCCNC1.CS(=O)(=O)OCCCn1nnc(-c2cccc(I)c2)n1>>CCOC(=O)C1CCCN(CCCn2nnc(-c3cccc(I)c3)n2)C1,,C1CCOC1,,CCN(CC)CC,,val
US20050065118A1,FC(F)(F)Oc1cccc(CBr)c1.Oc1cccc(-c2nnc(Nc3ccc(Cl)c(Cl)c3)s2)c1>>FC(F)(F)Oc1cccc(COc2cccc(-c3nnc(Nc4ccc(Cl)c(Cl)c4)s3)c2)c1,,C1CCOC1,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US20110201604A1,Cn1c(Nc2nc3ccc(Cl)cc3s2)nc2cc(C(=O)O)ccc21.NCCSCCO>>Cn1c(Nc2nc3ccc(Cl)cc3s2)nc2cc(C(=O)NCCSCCO)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04559402,Cc1nn2ccccc2c1C(=O)C1=CNCCC1.O=C=Nc1ccc(Cl)cc1>>Cc1nn2ccccc2c1C(=O)C1=CN(C(=O)Nc2ccc(Cl)cc2)CCC1,,ClCCl,,,,val
US20070219266A1,C[C@@H]1CNC[C@H]1C(=O)c1ccc(F)cc1.O=C(Cl)c1ccc(F)cc1>>C[C@@H]1CN(C(=O)c2ccc(F)cc2)C[C@H]1C(=O)c1ccc(F)cc1,,ClCCl,,CCN(CC)CC,,val
US20100184767A1,O=C1c2ccccc2C(=O)N1C[C@H]1CN(c2ccc(N3CCOCC3=O)cc2F)C(=O)O1>>NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2F)C(=O)O1,,CCO,,CN,,val
US20080227724A1,CCCCCCCCCC(C)(C)CC(=O)O.ClCCl>>CCCCCCCCCC(C)(C)CC(=O)Cl,CN(C)C=O,,,,,val
US06448236B1,CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CN)nc32)[C@@H]2OC(C)(C)O[C@@H]21.O=S(=O)(Cl)c1ccc2ccccc2c1>>CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CNS(=O)(=O)c4ccc5ccccc5c4)nc32)[C@H](O)[C@@H]1O,,ClCCl,,CCN(CC)CC,,val
US20080108594A1,BrC(Br)(Br)Br.COc1ccc(CO)cc1OC>>COc1ccc(CBr)cc1OC,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150266916A1,COc1ccc(Cc2cc([C@]3(OC)O[C@](C=O)(CO)[C@@H](OCc4ccccc4)[C@H](OCc4ccccc4)[C@H]3OCc3ccccc3)ccc2Cl)c(F)c1F>>COc1ccc(Cc2cc([C@]3(OC)OC(CO)(CO)[C@@H](OCc4ccccc4)[C@H](OCc4ccccc4)[C@H]3OCc3ccccc3)ccc2Cl)c(F)c1F,,CO,,[BH4-].[Na+],,val
US20140057895A1,CC(C)(C)OC(=O)N1CCC[C@H]1C=O.CCc1nn(-c2noc(C3CCNCC3)n2)c2ccccc12>>CCc1nn(-c2noc(C3CCN(C[C@@H]4CCCN4C(=O)OC(C)(C)C)CC3)n2)c2ccccc12,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20100168418A1,CCOC(=O)COc1cccc2c1ccc(=O)n2CCN1CCC(N(Cc2ccc3c(c2)OCCO3)C(=O)OC(C)(C)C)CC1>>CCOC(=O)COc1cccc2c1ccc(=O)n2CCN1CCC(NCc2ccc3c(c2)OCCO3)CC1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20130225567A1,CC(C)=O.Cc1noc(C)c1-c1ccc(NC(=O)C(C)N)nc1C#Cc1ccccc1>>Cc1noc(C)c1-c1ccc(NC(=O)C(C)NC(C)C)nc1C#Cc1ccccc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20140018368A1,Brc1ccccn1.CC1(C)OB(c2cc(N)ccc2Cl)OC1(C)C>>Nc1ccc(Cl)c(-c2ccccn2)c1,,C1COCCO1,O,O=C([O-])O.[Na+],,val
US05607939,ICCC1(c2ccccc2)COCc2ccccc21.O=C1NC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1CCC1(c2ccccc2)COCc2ccccc21,,CN(C)C=O,,[K],,val
US20040127552A1,COc1ccccc1SC[C@@H](O)CO.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>COc1ccccc1SC[C@@H](O)COC(c1ccccc1)(c1ccccc1)c1ccccc1,,CC#N,,c1ccncc1,,val
US20020016336A1,COC(=O)C1CN(C(=O)OC(C)(C)C)CC1NC(=O)c1ccc2c(ccn2Cc2cc(C)nc3ccccc23)c1>>COC(=O)C1CNCC1NC(=O)c1ccc2c(ccn2Cc2cc(C)nc3ccccc23)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04560686,COc1cccc(C(=O)Cl)c1OC.COc1ccccc1N1CCNCC1.NCCBr>>COc1ccccc1N1CCN(CCNC(=O)c2cccc(OC)c2OC)CC1,,CCCCO,CCOC(C)=O,Br,CCN(CC)CC,val
US07074819B2,CC(C)(C)[Si](C)(C)Cl.OCCCCCCCBr>>CC(C)(C)[Si](C)(C)OCCCCCCCBr,,C1CCOC1,,O,c1c[nH]cn1,val
US20100152207A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)c1ccc(Cl)c(Br)c1>>COC(=O)c1ccc(Cl)c(B2OC(C)(C)C(C)(C)O2)c1,,CN(C)C=O,,CC(=O)[O-].[K+],,val
US07495007B2,CC(C)(CO)COc1ccc(Cl)cc1C=O.O=C1Cc2ccc(Cl)cc2N1>>CC(C)(CO)COc1ccc(Cl)cc1/C=C1\C(=O)Nc2cc(Cl)ccc21,,CO,,C1CCNC1,,val
US20090186912A1,C[Si](C)(C)C#N.O=C1CCc2cc(Br)ccc21>>C[Si](C)(C)OC1(C#N)CCc2cc(Br)ccc21,,ClCCl,,C[N+]1([O-])CCOCC1,,val
US05710166,CCOC(=O)CCNC(=O)c1cccc(NCc2ccc(C=NN)cc2)c1>>NN=Cc1ccc(CNc2cccc(C(=O)NCCC(=O)O)c2)cc1,,CO,,[Li+].[OH-],,val
US04406690,Nc1cccc(O)n1.O=C1OC(=O)C2=C1CCCC2>>O=C1C2=C(CCCC2)C(=O)N1c1cccc(O)n1,,ClC(Cl)Cl,,CC(=O)O,,val
US06500946B1,CC(=O)OC[C@@H]1C[C@@H](OC(C)=O)[C@H](n2cnc3c(O)ncnc32)O1.O=S(Cl)Cl>>CC(=O)OC[C@@H]1C[C@@H](OC(C)=O)[C@H](n2cnc3c(Cl)ncnc32)O1,,ClCCl,,CN(C)C=O,O,val
US20080132502A1,CC(=O)Nc1nc(C)c(-c2cnc(Cl)c(NS(=O)(=O)c3c(C)nn(C)c3Cl)c2)s1>>Cc1nc(N)sc1-c1cnc(Cl)c(NS(=O)(=O)c2c(C)nn(C)c2Cl)c1,,CCO,,Cl,,val
US07238716B2,COC(=O)Cc1cc(Br)ccc1O.Cc1oc(-c2ccccc2)nc1COc1ccc(CCl)cc1>>COC(=O)Cc1cc(Br)ccc1OCc1ccc(OCc2nc(-c3ccccc3)oc2C)cc1,,O,,CN(C)C=O,[H-].[Na+],val
US04263291,CON=C(C(=O)NC1(OC)C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CSc3nnnn3C)CS[C@@H]21)c1csnn1>>CON=C(C(=O)NC1(OC)C(=O)N2C(C(=O)O)=C(CSc3nnnn3C)CS[C@@H]21)c1csnn1,,ClCCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20090029965A1,COC(=O)c1ccc(CCC(=O)OC(C)(C)C)c(C)c1>>COC(=O)c1ccc(CCC(=O)O)c(C)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160145251A1,CC(C)(C)OC(=O)N1CC(CO)CC(F)(F)C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CC(COS(C)(=O)=O)CC(F)(F)C1,,ClCCl,,CCN(CC)CC,,val
US20110118245A1,CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3ncnc4cc(O)ccc34)c2)no1.COCCBr>>COCCOc1ccc2c(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C)on4)c3)ncnc2c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100184815A1,CC(C)(C)OC(=O)C(C)(C)Oc1ccc(C(=O)O)cc1.CCCCCCCn1c(CO)nn(Cc2ccc(C)cc2)c1=O>>CCCCCCCn1c(COC(=O)c2ccc(OC(C)(C)C(=O)O)cc2)nn(Cc2ccc(C)cc2)c1=O,CN(C)c1ccncc1,CN(C)C=O,,ClCCCl,,val
US05912261,CCOC(=O)CBr.O=c1cc[nH]c(=O)[nH]1>>CCOC(=O)Cn1ccc(=O)[nH]c1=O,,CS(C)=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US04001419,CC(=O)OC(C)=O.CN1CCC2(CC1)c1ccccc1Oc1c(O)cccc12.Cl>>CC(=O)Oc1cccc2c1Oc1ccccc1C21CCN(C)CC1.Cl,,c1ccncc1,,,,val
US20040162318A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N)c(OC(C)C)cc12.COS(=O)(=O)OC>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(NC)c(OC(C)C)cc12,,CCOCC,,CCN(CC)CC,O,val
US20070244095A1,Cc1cc2c(cc1C(F)(F)F)N(CCOCc1ccccc1)CCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1>>Cc1cc2c(cc1C(F)(F)F)N(CCO)CCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1,[Pd],CCO,,,,val
US20130237535A1,COc1cc(N)ccc1Br.Cl.O=S=O>>COc1cc(S(=O)(=O)Cl)ccc1Br,Cl[Cu],CC(=O)O,O,O=N[O-].[Na+],,val
US20120116075A1,CCN(CC)CC.Cc1ccc(C(=O)Nc2ccc(F)c(Cl)c2)cc1.O=C(Cl)C=Cc1cccnc1>>Cc1ccc(C(=O)Nc2ccc(F)c(Cl)c2)cc1NC(=O)C=Cc1cccnc1,,ClCCl,,Cl,O=C([O-])[O-].[K+].[K+],val
US06071935,C=C1C(CCC(=O)OCC)CC2CC1C2(C)C>>C=C1C(CCC(=O)O)CC2CC1C2(C)C,,CCO,,[Na+].[OH-],,val
US20120277244A1,CC(C)(C)OC(=O)N1CC(=O)NC(c2cc(Br)ccc2F)(C(F)F)C1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)(C)OC(=O)N1CC(=S)NC(c2cc(Br)ccc2F)(C(F)F)C1,,C1CCOC1,,,,val
US03998843,COS(=O)(=O)c1ccc(C)cc1.c1ccc([C@H]2CCCC[C@H]2N2CCCC2)cc1>>C[N+]1([C@@H]2CCCC[C@@H]2c2ccccc2)CCCC1.Cc1ccc(S(=O)(=O)[O-])cc1,,CCOC(C)=O,,,,val
US20120208788A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1c(OC(F)(F)F)cc(N)c(OCc2ccccc2)c1C(=O)Oc1ccccc1>>Cc1c(OC(F)(F)F)cc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(OCc2ccccc2)c1C(=O)Oc1ccccc1,CN(C)c1ccncc1,CN(C)C=O,,,,val
US06124453,CC[C@H]1C[C@H](C)[C@@]2(NC1=O)O[C@@H](C[C@H](O)[C@@H](C)CC/C=C/C=C(\C)[C@@H]1CC=CC=C[C@H](O)[C@H](C)[C@H]3O[C@](C)(OC)CC[C@H]3C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc3cccc(O)c3)C(=O)N3CCC[C@@H](N3)C(=O)O1)[C@H](C)[C@H](O)[C@@H]2C>>CC[C@H]1C[C@H](C)[C@@]2(NC1=O)O[C@@H](C[C@H](O)[C@@H](C)CC/C=C/C=C(\C)[C@@H]1CC=CC=C[C@H](O)[C@H](C)[C@@H](O)[C@@H](CCC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc3cccc(O)c3)C(=O)N3CCC[C@H](N3)C(=O)O1)[C@H](C)[C@H](O)[C@@H]2C,,C1CCOC1,O,O=S(=O)(O)O,,val
US20020082292A1,OCCCBr.Oc1ccc(Oc2ccccc2)cc1Cl>>OCCCOc1ccc(Oc2ccccc2)cc1Cl,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080274892A1,CCC1COC(=O)N1Cc1ccccc1[N+](=O)[O-]>>CCC1COC(=O)N1Cc1ccccc1N,[Fe],CCO,O,[Cl-].[NH4+],,val
US20070208054A1,CC(C)(C)[Si](C)(C)Cl.CC(CO)c1ccc(Br)cc1>>CC(CO[Si](C)(C)C(C)(C)C)c1ccc(Br)cc1,,CN(C)C=O,,c1c[nH]cn1,,val
US04886817,ClCC=Cc1ccccc1.O=C(NCCCl)Nc1cccnc1>>O=C1N(C/C=C/c2ccccc2)CCN1c1cccnc1,,CS(C)=O,O,[K+].[OH-],,val
US20130096144A1,CC(C)(C)OC(=O)N[C@@H](Cc1cccc(Br)c1)C(=O)O>>CC(C)(C)OC(=O)N[C@H](CO)Cc1cccc(Br)c1,,C1CCOC1,C1CCOC1,,,val
US20150126488A1,Cc1ccc(S(=O)(=O)n2ccc3c(-c4ccc(F)c(C(F)(F)F)c4)nc(C#N)nc32)cc1>>N#Cc1nc(-c2ccc(F)c(C(F)(F)F)c2)c2cc[nH]c2n1,,CC(=O)N(C)C,,,,val
US20070010537A1,NO.O=Cc1cccc2[nH]c(=O)n(-c3cccc(S(=O)(=O)N4CCCc5ccccc54)c3)c(=O)c12>>O=c1[nH]c2cccc(C=NO)c2c(=O)n1-c1cccc(S(=O)(=O)N2CCCc3ccccc32)c1,,CN1CCCC1=O,,Cl,,val
US20060154965A1,CN(CCNC1CCCc2cc(S(=O)(=O)c3ccccc3)ccc21)C(=O)OC(C)(C)C>>CNCCNC1CCCc2cc(S(=O)(=O)c3ccccc3)ccc21,,C1CCOC1,CCOCC,Cl,,val
US20130018033A1,CCCS(=O)(=O)Nc1ccc(F)c(NC(=O)c2cccc3c(Cl)ncnc23)c1Cl.N>>CCCS(=O)(=O)Nc1ccc(F)c(NC(=O)c2cccc3c(N)ncnc23)c1Cl,,CC(C)O,,,,val
US03981932,CCOC(=O)C(=O)c1ccc(C2CCCCC2)c(S)c1.COS(=O)(=O)OC>>CCOC(=O)C(=O)c1ccc(C2CCCCC2)c(SC)c1,,O,,[Na+].[OH-],,val
US05677459,CN1CCCC1c1cncc(-c2ccc(O[Si](C)(C)C(C)(C)C)cc2)c1>>CN1CCCC1c1cncc(-c2ccc(O)cc2)c1,,CO,,[Cs+].[F-],,val
US20060052392A1,COC(=O)c1cc(C)c(C)cc1C=O.Nc1cccc(F)c1>>COC(=O)c1cc(C)c(C)cc1C=Nc1cccc(F)c1,,CCO,,,,val
US20050282808A1,CC(C)(C)OC(=O)Nc1cccc2oc(C(=O)Nc3ccc(Cl)cn3)c(NC(=O)[C@@H]3CC[C@@H](N4CCCC4=O)CC3)c12>>Nc1cccc2oc(C(=O)Nc3ccc(Cl)cn3)c(NC(=O)[C@@H]3CC[C@@H](N4CCCC4=O)CC3)c12,,O=C(O)C(F)(F)F,,,,val
US20110046133A1,COC(=O)CNc1cc(C)c(-c2nc3cc(C(=O)Nc4ccc(C)c(C)c4)ccc3[nH]2)c(C)c1>>Cc1ccc(NC(=O)c2ccc3[nH]c(-c4c(C)cc(NCCO)cc4C)nc3c2)cc1C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110015157A1,CC1(C)C(=O)N(Br)C(=O)N1Br.CC[C@H](N)c1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC[C@H](NC(=O)C(F)(F)F)c1ccc(Br)cc1,,ClCCl,,,,val
US20110009402A1,C=C(C)CC1(c2ccccc2)CCNC(=O)O1.O=C(OO)c1cccc(Cl)c1>>CC1(CC2(c3ccccc3)CCNC(=O)O2)CO1,,COC(C)(C)C,,ClCCl,,val
US06002008,N#Cc1cccc(N)c1.N#Cc1cnc2ccc([N+](=O)[O-])cc2c1Cl>>N#Cc1cccc(Nc2c(C#N)cnc3ccc([N+](=O)[O-])cc23)c1,,CCO,,,,val
US20030162777A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc2cc(O)ccc2n1>>Cc1ccc2cc(OC(=O)OC(C)(C)C)ccc2n1,,C1CCOC1,,CN(C)c1ccccn1,,val
US20030199478A1,COc1cccc(-c2ccc3c(c2)NC(=O)C3=CO)c1.Nc1ccc(N2CCOCC2)cc1>>COc1cccc(-c2ccc3c(c2)NC(=O)C3=CNc2ccc(N3CCOCC3)cc2)c1,,C1CCOC1,,,,val
US20140127239A1,COc1cc(C(=O)N2CC(=O)C[C@H]2CO[Si](C)(C)C(C)(C)C)c([N+](=O)[O-])cc1O[Si](C(C)C)(C(C)C)C(C)C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1cc(C(=O)N2C=C(OS(=O)(=O)C(F)(F)F)C[C@H]2CO[Si](C)(C)C(C)(C)C)c([N+](=O)[O-])cc1O[Si](C(C)C)(C(C)C)C(C)C,,ClCCl,,Cc1cccc(C)n1,,val
US20040167119A1,C=O.CNC.COc1ccc2[nH]ccc2c1C>>COc1ccc2[nH]cc(CN(C)C)c2c1C,,CCO,,CC(=O)O,,val
US20150038438A1,COc1ccc(Cn2c3c(c(O)c(C(=O)O)c2=O)CCCCc2cc4c(cc2-3)cc(CO)n4C)c(OC)c1>>COc1ccc(Cn2c3c(c(O)c(C(=O)O)c2=O)CCCCc2cc4c(cc2-3)cc(C=O)n4C)c(OC)c1,O=[Mn]=O,ClCCl,,,,val
US06441017B1,CC(C)[Si](OC(=O)N(CCc1cncn1Cc1ccc(C#N)c(F)c1)[C@H]1CCN(C(=O)OC(C)(C)C)C1)(C(C)C)C(C)C>>CC(C)[Si](OC(=O)N(CCc1cncn1Cc1ccc(C#N)c(F)c1)[C@H]1CCNC1)(C(C)C)C(C)C,,ClCCl,O,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20110065708A1,C=C(OCC)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1>>CC(=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1,,CC(=O)O,,Cl,,val
US20030036542A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC(N)=S>>CC(C)(C)OC(=O)NC(=S)NC(=O)OC(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20120016125A1,ClC[C@@H]1CO1.Fc1cc(F)c(Br)cc1F>>O[C@H](CCl)Cc1cc(F)c(F)cc1F,I[Cu]I,C1CCOC1,,CC(C)[Mg]Cl,Cl,val
US20090149501A1,CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(C(=O)O)cc23)C1(C)C.CN>>CNC(=O)c1ccc2c(c1)c(C(=O)C1C(C)(C)C1(C)C)cn2CC1CCOCC1,,C1CCOC1,CCOC(C)=O,O=C(n1ccnc1)n1ccnc1,,val
US20140275087A1,Cn1cnc(S(=O)(=O)N2C[C@@H](c3ccc(F)cc3)[C@H](C=C(Br)Br)C2)c1>>C#C[C@H]1CN(S(=O)(=O)c2cn(C)cn2)C[C@@H]1c1ccc(F)cc1,,C1CCOC1,,[Li]CCCC,,val
US04816467,CCOC(=O)c1nn(-c2ccccc2)c2c1COc1ccccc1-2>>O=C(O)c1nn(-c2ccccc2)c2c1COc1ccccc1-2,,C1COCCO1,CCO,Cl,[K+].[OH-],val
US06071670,C=C(C)C(=O)O.C=C(C)C(=O)OC(C)(C)C.C=C(C)C(=O)OC12CC3CC(CC(C3)C1)C2>>C=C(C)C(=O)O.C=C(C)C(=O)OC(C)(C)C.C=C(C)C(=O)OC12CC3CC(CC(C3)C1)C2,,C1CCOC1,,,,val
US05068325,N#Cc1ccccc1C=CCBr.Nc1nc2c(s1)CCNCC2>>N#Cc1ccccc1C=CCN1CCc2nc(N)sc2CC1,,CN(C)C=O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US03952114,CNCCNC.Cc1ccc(C=O)cc1>>Cc1ccc(C2N(C)CCN2C)cc1,,c1ccccc1,,,,val
US20150191461A1,Ic1cn[nH]c1.O=C1NCCC(CBr)O1>>O=C1NCCC(Cn2cc(I)cn2)O1,,CN(C)C=O,O,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20070004736A1,CC(C)(C)OC(=O)N1CCC(N)CC1.COC(CBr)OC>>COC(CNC1CCN(C(=O)OC(C)(C)C)CC1)OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100113547A1,C=CCOCC1(c2cccc(C#N)c2)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)N1C>>CN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(CO)c1cccc(C#N)c1,,ClCCl,,,,val
US20070244173A1,Cc1nc2c(O)c(C(=O)[C@@H]3OC(C)(C)O[C@H]3c3ccccc3)ccc2n1C>>Cc1nc2c(O)c(C(=O)[C@H](O)[C@@H](O)c3ccccc3)ccc2n1C,,Cl,,[Na+].[OH-],,val
US20110195954A1,C#CC1CC(N2CCc3cc(OC)ccc3NC2=O)CCN1c1cc(C(=O)N2CCc3cc(F)ccc32)ncc1[Si](C)(C)C>>C#Cc1cnc(C(=O)N2CCc3cc(F)ccc32)cc1N1CCC(N2CCc3cc(OC)ccc3NC2=O)CC1,,C1CCOC1,,Cl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US04230715,CCOCCC(=O)O.NNC(=S)NN>>CCOCCc1nnc(S)n1N,,CCOCC,,,,val
US20070066573A1,CCOC(=O)CC(=O)c1ccc(Br)cc1.O=N[O-]>>CCOC(=O)C(NO)C(=O)c1ccc(Br)cc1,,C1CCOC1,O,CC(=O)O,,val
US20030171362A1,COc1ccc2c(c1)CC(=O)CC2.NC1CCN(Cc2ccccc2)CC1>>COc1ccc2c(c1)CC(NC1CCN(Cc3ccccc3)CC1)CC2,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110183973A1,CCOc1ccccc1C(=O)O.Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12>>CCOc1ccccc1C(=O)Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140323475A1,O=Cc1cc(Cl)ccc1OCCC1CCOCC1>>OCc1cc(Cl)ccc1OCCC1CCOCC1,,CCO,,[BH4-].[Na+],,val
US20150210659A1,CCOC(=O)CN1CCN(C(=O)c2ccc(C(F)(F)F)cc2)CC1.NN>>NNC(=O)CN1CCN(C(=O)c2ccc(C(F)(F)F)cc2)CC1,,CCO,,,,val
US20100216860A1,COc1cccc2c1c(N(S(=O)(=O)c1ccc(Cl)s1)S(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CNC(=O)OC(C)(C)C)cc1>>COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CNC(=O)OC(C)(C)C)cc1,,CO,,[Na+].[OH-],,val
US20120058988A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.NC(=O)c1cc(Br)cc2c1[nH]c1cc(I)ccc12>>CC(C)(C)OC(=O)N1CC=C(c2ccc3c(c2)[nH]c2c(C(N)=O)cc(Br)cc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US04251531,CCOC(=O)c1ccc(NC(=O)c2ccccc2OC)cc1.CCOC(N)=O>>COc1ccccc1-c1nc2ccc(C(=O)O)cc2c(=O)[nH]1,,Cc1ccccc1C,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20080021043A1,COC(=O)C1(c2ccnc(-c3ccc(C(F)(F)F)cc3)c2)CC=CC1>>COC(=O)C1([C@H]2CCN[C@@H](c3ccc(C(F)(F)F)cc3)C2)CCCC1,O=[Pt]=O,CO,,Cl,,val
US20160060248A1,CCOC(=O)CCN(C(=O)c1ccc(NC)c(N)c1)c1ccccn1.O=C(Cl)C(Cl)Cl>>CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(C(Cl)Cl)n2C)c1ccccn1,,CC#N,,,,val
US04012513,CC(=O)CCC(=O)O.NN(c1ccccc1)c1cc(Cl)nc(Cl)n1>>Cc1c(CC(=O)O)c2ccccc2n1-c1cc(Cl)nc(Cl)n1,,O,,Cl,,val
US20110257171A1,BrBr.Fc1ccc(-c2ccc3nccn3c2)cc1>>Fc1ccc(-c2ccc3ncc(Br)n3c2)cc1,,CCO,O,O=C([O-])O.[Na+],,val
US05104869,CCOC(=O)CCC(=O)OCC.COc1cc(C=O)cc(OC)c1OC>>COc1cc(C=C(CC(=O)O)C(=O)O)cc(OC)c1OC,,CCO,,[Na+].[OH-],,val
US20030195211A1,O=c1c2cc(F)c(F)cc2nc(CCl)n1-c1ccccc1Cl.Sc1ncnc2nc[nH]c12>>O=c1c2cc(F)c(F)cc2nc(CSc2ncnc3[nH]cnc23)n1-c1ccccc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20140031355A1,CC(NS(=O)C(C)(C)C)c1cnc2c(Cl)cccc2c1-c1ccccn1>>CC(N)c1cnc2c(Cl)cccc2c1-c1ccccn1,,C1CCOC1,,Cl,[Na+].[OH-],val
US03993679,CCCCN(C(=O)C(=O)OCC)c1cccc(NC(=O)C(=O)OCC)c1>>CCCCN(C(=O)C(=O)O)c1cccc(NC(=O)C(=O)O)c1,,[Na+],[OH-],,,val
US20130131016A1,C=C(c1cc(Cl)c(C(F)(F)F)c(Cl)c1)C(F)(F)F.CC1(C)OB(O)c2ccc(C(Cl)=NO)cc21>>CC1(C)OB(O)c2ccc(C3=NOC(c4cc(Cl)c(C(F)(F)F)c(Cl)c4)(C(F)(F)F)C3)cc21,,CN(C)C=O,,,,val
US04684652,CCC(C)NC.O=C(O)c1cc(-c2ccccc2)cc2ccccc12>>CCC(C)N(C)C(=O)c1cc(-c2ccccc2)cc2ccccc12,,c1ccncc1,,O=S(Cl)Cl,,val
US20050131052A1,CC(C)(C)OC(=O)N[C@@H]1c2ccccc2C[C@@H]1O.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N[C@@H]1c2ccccc2C[C@@H]1OS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20160002175A1,CC(N)Cc1c[nH]c2ccccc12.Cc1c(Cl)cccc1-c1cc(Cl)nc(N)n1>>Cc1c(Cl)cccc1-c1cc(NC(C)Cc2c[nH]c3ccccc23)nc(N)n1,,CO,,,,val
US20080114022A1,C1COCCN1.COC(=O)Cc1c(C)n(S(=O)(=O)c2ccc(F)c(C#N)c2)c2ncccc12>>COC(=O)Cc1c(C)n(S(=O)(=O)c2ccc(N3CCOCC3)c(C#N)c2)c2ncccc12,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100210635A1,O=C(O)CCc1ccccc1.c1ccc(C[C@@H]2CN(Cc3ccccc3)CCN2)cc1>>O=C(CCc1ccccc1)N1CCNC[C@H]1Cc1ccccc1,,CCOCC,ClCCl,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20120122764A1,BrCc1ccccc1.O=C(O)CCc1ccc(-c2ccccc2)cc1>>O=C(CCc1ccc(-c2ccccc2)cc1)OCc1ccccc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US03953465,O=C(NCC(Cl)Cl)C(Oc1cccc(C(F)(F)F)c1)c1ccc(Cl)cc1>>FC(F)(F)c1cccc(OC(c2ccc(Cl)cc2)c2ncco2)c1,,CCO,ClC(Cl)Cl,O,[Na],val
US20070249593A1,CC(=O)OCC(COC(C)=O)c1ccc(N)cc1.O=C1CCC(=O)N1Br>>CC(=O)OCC(COC(C)=O)c1ccc(N)c(Br)c1,,ClCCl,,,,val
US20080312270A1,COC(=O)Cc1ccc(Oc2cc3c(cc2N)C(=O)NC3=O)c(Cl)c1.O=S(=O)(Cl)c1ccc(Cl)cc1>>COC(=O)Cc1ccc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(Cl)cc2)C(=O)NC3=O)c(Cl)c1,,ClCCl,,Cc1cccc(C)n1,,val
US05608056,C=CCOC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1CN1CCN(C=O)CC1=O>>C=CCOC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1CN1CCNCC1=O,,CO,,Cl,[Na],val
US20100150827A1,CCn1c(=O)c(Br)cc2c(C)nc(Nc3ccc(-n4ccnc4)cc3)nc21.OB(O)c1cc[nH]n1>>CCn1c(=O)c(-c2ccn[nH]2)cc2c(C)nc(Nc3ccc(-n4ccnc4)cc3)nc21,,CC#N,O,,,val
US05550260,C=CCC1=C(C)C(O[SiH3])(C(C)(C)C)C(C)(C)C1=C>>C=CCC1=C(C)C(O)CC1=C,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040092582A1,CCOC(=O)C(C)(C)c1cccc(C=O)c1.NO>>CCOC(=O)C(C)(C)c1cccc(C#N)c1,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20080090851A1,CCOC(=O)C(C)(C)N1CCC(NCc2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.O=C(O)Cn1c(CCc2cccc(F)c2F)nc(=O)c2cccnc21>>CCOC(=O)C(C)(C)N1CCC(N(Cc2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)C(=O)Cn2c(CCc3cccc(F)c3F)nc(=O)c3ccccc32)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20090131458A1,BrCC1CCOCC1.CCCC(C)Oc1nc(N)c2nc(OC)[nH]c2n1>>CCCC(C)Oc1nc(N)c2nc(OC)n(CC3CCOCC3)c2n1,,CCOC(C)=O,CN(C)C=O,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20090325988A1,C#CC[C@](O)(CC(C)(C)c1ccc(F)cc1CO)C(F)(F)F>>C#CC[C@](O)(CC(C)(C)c1ccc(F)cc1C=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,CS(C)=O,val
US20160222033A1,NN.O=C(CC(=O)C(F)(F)F)C1CC1>>FC(F)(F)c1cc(C2CC2)n[nH]1,,CCO,,O,,val
US20140364433A1,C[C@@H]1CCCN[C@@H]1CN1C(=O)c2ccccc2C1=O.O=C(O)c1cc(F)ccc1I>>C[C@@H]1CCCN(C(=O)c2cc(F)ccc2I)[C@@H]1CN1C(=O)c2ccccc2C1=O,,CC(=O)N(C)C,CCOC(C)=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060194768A1,COC(=O)c1ccc(-c2csc(N)n2)cc1.O=S(=O)(Cl)c1ccccc1>>COC(=O)c1ccc(-c2csc(NS(=O)(=O)c3ccccc3)n2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US05212320,CCOC(=O)CCCBr.c1ccc2[nH]ccc2c1>>CCOC(=O)CCCn1ccc2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080293711A1,NCc1ccc(C(=O)NNc2ccccc2)cc1.O=Cc1ccccn1>>O=C(NNc1ccccc1)c1ccc(CNCc2ccccn2)cc1,,CO,,[BH4-].[Na+],,val
US20050026964A1,CCOC(=O)c1cnc(Cl)cc1Nc1ccc(I)cc1F.O>>CCOC(=O)c1c[nH]c(=O)cc1Nc1ccc(I)cc1F,,CC(=O)O,,,,val
US04885027,CCOC(=O)CNC.O=S(=O)(Cl)Cc1cccc(C(F)(F)F)c1>>CCOC(=O)CN(C)S(=O)(=O)Cc1cccc(C(F)(F)F)c1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20080261979A1,NC(=O)C1CCCCC1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>NC(=S)C1CCCCC1,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20090197877A1,COC(=O)c1cc(Br)cc([N+](=O)[O-])c1NC(=O)C(F)(F)F>>COC(=O)c1cc(Br)cc([N+](=O)[O-])c1N,,CO,,Cl,,val
US04655816,CCOC(=O)c1c(Cl)cc(C(F)(F)F)nc1C(F)(F)F.Sc1ccccc1>>CCOC(=O)c1c(Sc2ccccc2)cc(C(F)(F)F)nc1C(F)(F)F,,CCO,,C,C[O-].[Na+],val
US20110245205A1,Cc1cc(Nc2nccc(O)n2)cc(-c2cnc(C(C)(O)C(F)(F)F)s2)c1.O=P(Cl)(Cl)Cl>>Cc1cc(Nc2nccc(Cl)n2)cc(-c2cnc(C(C)(O)C(F)(F)F)s2)c1,,C1COCCO1,,,,val
US20110172230A1,CC(C)(C)OC(=O)N1CCN(Cc2cccc(OCc3ccccc3)c2)CC1.Cl>>Cl.c1ccc(COc2cccc(CN3CCNCC3)c2)cc1,,CCOC(C)=O,,,,val
US06949680B2,CCCCCCCCCCOCCCC1(c2ccc(C)cc2)OCCO1>>CCCCCCCCCCOCCCC(=O)c1ccc(C)cc1,,C1CCOC1,,Cl,,val
US20130035331A1,C1CCNC1.ClCc1cccc(I)c1>>Ic1cccc(CN2CCCC2)c1,,C1COCCO1,,,,val
US03932410,C=CCCN1CCC(O)N(c2nnc(OC)s2)C1=O.CCO>>C=CCCN1CCC(OCC)N(c2nnc(OC)s2)C1=O,,CCO,,Cc1ccccc1S(=O)(=O)O,,val
US20090270389A1,CSc1ncc(C#N)c(Cl)n1.N[C@H]1CC[C@H](O)C1>>CSc1ncc(C#N)c(N[C@H]2CC[C@H](O)C2)n1,,C1CCOC1,,,,val
US20090130455A1,COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.Cc1ccc(S(=O)(=O)OCC(O)CO)cc1>>COc1ccc(C(OCC(O)COS(=O)(=O)c2ccc(C)cc2)(c2ccccc2)c2ccc(OC)cc2)cc1,,c1ccncc1,,O=C([O-])O.[Na+],,val
US20040157883A1,N=C(N)NC(N)=S.O=C(CBr)c1ccccc1>>N=C(N)Nc1nc(-c2ccccc2)cs1,,CC(C)=O,,,,val
US20100286145A1,CNCc1nc(C)cs1.COC(=O)c1cc(CO)cc(C(=O)O)c1>>COC(=O)c1cc(CO)cc(C(=O)N(C)Cc2nc(C)cs2)c1,,ClC(Cl)Cl,ClCCl,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20120178736A1,C1CC(C2COC2)CCN1.Cn1c(C=O)nc2c(N3CCOCC3)nc(-n3c(CCO)nc4ccccc43)nc21>>CC(O)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C4COC4)CC3)n(C)c2n1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120052046A1,COC(=O)[C@@H](N)c1ccccc1.Cl.O=P(Cl)(Cl)Oc1cccc2ccccc12>>COC(=O)[C@@H](N=[P+]([O-])Oc1c(Cl)ccc2ccccc12)c1ccccc1,,ClCCl,,,,val
US20120270838A1,CNc1cc(C)c(CCS(=O)(=O)N2CCC3(CC2)N=C(C2CCC(C)CC2)NC3=O)c(C)c1.O=C(N=C=S)c1ccccc1>>Cc1cc(N(C)C(=S)NC(=O)c2ccccc2)cc(C)c1CCS(=O)(=O)N1CCC2(CC1)N=C(C1CCC(C)CC1)NC2=O,,CC(C)=O,,,,val
US20140066424A1,Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)n[nH]1.ClCc1cn2ccccc2n1>>Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1cn2ccccc2n1,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130210831A1,CC(C)(C)OC(=O)N[C@@H]1CCNC1.C[Si](C)(C)CCOCn1ccc2c(Cl)ncnc21>>CC(C)(C)OC(=O)N[C@@H]1CCN(c2ncnc3c2ccn3COCC[Si](C)(C)C)C1,,CCO,,CCN(C(C)C)C(C)C,,val
US20070037881A1,COc1cc(C#N)ccc1Oc1ccc(Cl)cc1Cl>>N#Cc1ccc(Oc2ccc(Cl)cc2Cl)c(O)c1,,ClCCl,,O,,val
US04006243,C=CCCl.Oc1ccccc1-n1ccnc1>>C=CCOc1ccccc1-n1ccnc1.Cl,,CN(C)C=O,,[H-].[Na+],,val
US20150038437A1,CCC(=O)N(C)OC.Cn1c(CO[Si](C)(C)C(C)(C)C)cc2cc(Br)ccc21>>CCC(=O)c1ccc2c(c1)cc(CO[Si](C)(C)C(C)(C)C)n2C,,C1CCOC1,,[Li]CCCC,,val
US20040054182A1,CC(C)(C)OC(=O)N1CCC(CCn2c(-c3ccccc3)nc3c(Cl)nc4ccccc4c32)CC1.NC(N)=S>>CC(C)(C)OC(=O)N1CCC(CCn2c(-c3ccccc3)nc3c(S)nc4ccccc4c32)CC1,,CCN(CC)CC,,CCO,,val
US20080139558A1,Cc1ccc2[nH]c(=O)c(C=O)cc2c1.NCc1ccccc1>>Cc1ccc2[nH]c(=O)c(CNCc3ccccc3)cc2c1,,C1CCOC1,,CC(=O)O,,val
US05623081,CC(C)(C)[Si](OC[C@@H]1CCC(O)S1)(c1ccccc1)c1ccccc1.CC(O)=S>>CC(=O)[SH]1C(O)CC[C@H]1CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,ClCCl,,Cc1ccccc1S(=O)(=O)O,,val
US20080188514A1,CCCS(=O)(=O)Nc1ccc(F)c(C=O)c1F.c1cc2cc(OC3CCCC3)cnc2[nH]1>>CCCS(=O)(=O)Nc1ccc(F)c(C(O)c2c[nH]c3ncc(OC4CCCC4)cc23)c1F,,CO,,O,[K+].[OH-],val
US05068325,COc1ccccc1C=CCCl.Nc1nc2c(s1)CCNCC2>>COc1ccccc1C=CCN1CCc2nc(N)sc2CC1,,ClC(Cl)Cl,,,,val
US20050049203A1,COCOc1cnccc1C(O)c1ccc(CCOC(=O)c2ccccc2)cc1>>O=C(OCCc1ccc(Cc2ccncc2O)cc1)c1ccccc1,,CCO,,Cl,,val
US06620837B1,COC(=O)CCCOc1ccc(-c2sc3ccccc3c2Cc2ccc(OCCN3CCCC3)cc2)cc1C(=O)OC.O=C(O)C(=O)O>>COC(=O)CCCOc1ccc(-c2sc3ccccc3c2Cc2ccc(OCCN3CCCC3)cc2)cc1C(=O)OC.O=C(O)C(=O)O,,CCOC(C)=O,,ClCCl,,val
US20050209323A1,N#CC(C#N)CCC(F)(F)F.O=[N+]([O-])c1ccc(CCl)c(Cl)c1>>N#CC(C#N)(CCC(F)(F)F)Cc1ccc([N+](=O)[O-])cc1Cl,,CN(C)C=O,,[H-].[Na+],,val
US20080146547A1,N#C[Cu].O=C(Nc1cccc(C(F)(F)F)c1)c1ccc2c(NCc3ccccc3)nnc(I)c2c1>>N#Cc1nnc(NCc2ccccc2)c2ccc(C(=O)Nc3cccc(C(F)(F)F)c3)cc12,,c1ccncc1,,,,val
US20020016337A1,CC(C)(C)OC(=O)N1CCCC(CNc2cccnc2)C1.CCC(=O)Cl>>CCC(=O)N(CC1CCCN(C(=O)OC(C)(C)C)C1)c1cccnc1,,ClCCl,,,,val
US20020016322A1,CC1(C)CS1.CCOC(=O)C1CCNCC1>>CCOC(=O)C1CCN(CC(C)(C)S)CC1,,c1ccccc1,,O,,val
US20130123509A1,CCOC(=O)CBr.O=C1CCC(NC(=O)OCc2ccccc2)N1>>CCOC(=O)CN1C(=O)CCC1NC(=O)OCc1ccccc1,,CC#N,,[H-].[Na+],,val
US04608374,Cc1cc(C)c(CCl)c(C)c1.c1ccc2c(c1)Cn1cccc1C(C1CCNCC1)O2>>Cc1cc(C)c(CN2CCC(C3Oc4ccccc4Cn4cccc43)CC2)c(C)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05508385,CCCCOC(OCCCC)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1.Cl>>CCCCOC(OCCCC)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccccc1.Cl,[Pd],CO,,[H][H],,val
US20100249229A1,COP(=O)(CC(=O)OC(C)(C)C)OC.O=C1CC2CC(C3CCCC3)=CC12>>CC(C)(C)OC(=O)C=C1C[C@@H]2CC(C3CCCC3)=C[C@H]12,,O,,C1CCOC1,[H-].[Na+],val
US04565425,BrC(Br)(Br)Br.O=CC1CCC(=O)CC1>>O=C1CCC(C=C(Br)Br)CC1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100160371A1,CC(C)(C)c1cc(C(N)=O)c(N)s1.Cc1ccc(N=C=O)cc1>>Cc1ccc(NC(=O)Nc2sc(C(C)(C)C)cc2C(N)=O)cc1,,Cc1ccccc1,,,,val
US20030119878A1,CNCCc1ccccn1.Cc1c(Br)c(=O)c(C=C=O)c(C)n1Cc1c(F)cccc1F>>Cc1c(Br)c(=O)c(CN(C)CCc2ccccn2)c(C)n1Cc1c(F)cccc1F,,ClCCl,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US06143764,CCc1ccc(N=C=O)cc1.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC>>CCc1ccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1,,Cc1ccccc1,,,,val
US20070015788A1,CN(C)C=NN=CN(C)C.NC1CCN(Cc2ccccc2)CC1>>c1ccc(CN2CCC(n3cnnc3)CC2)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05284847,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1c(C(C)C)csc1N>>CCOC(=O)c1c(C(C)C)csc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,CN(C)c1ccncc1,c1ccncc1,,,,val
US20080096877A1,CI.COCn1c(C(=O)NCC(SCc2ccccc2)C(OC)OC)cc2cccc(NS(=O)(=O)c3ccccn3)c21>>COCn1c(C(=O)NCC(SCc2ccccc2)C(OC)OC)cc2cccc(N(C)S(=O)(=O)c3ccccn3)c21,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20100022518A1,CC1C(=O)N(C(CO)CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CCN1c1cccc(C(F)(F)F)c1.CI>>COCC(CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)N1CCN(c2cccc(C(F)(F)F)c2)C(C)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20160159752A1,O=C(Nc1cccc(F)c1CC[C@@H](CO)NS(=O)(=O)c1ccccc1)C(OCc1ccccc1)C(c1ccccc1)c1ccccc1>>O=C(Nc1cccc(F)c1CCC1C[N@@]1S(=O)(=O)c1ccccc1)C(OCc1ccccc1)C(c1ccccc1)c1ccccc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05646172,CN1CCC2(CC1)NC(=O)N(c1ccc(C#N)c(C(F)(F)F)c1)C2=N.CO>>CN1CCC2(CC1)NC(=O)N(c1ccc(C#N)c(C(F)(F)F)c1)C2=O,,CCOC(C)=O,,[Na+].[OH-],[Cl-].[NH4+],val
US20150361079A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.Cc1ccc(S(=O)(=O)O)cc1.Nc1cc(Br)ccc1C(=O)Nc1ccc(Cl)cc1>>Cc1ccc(S(=O)(=O)O)cc1.O=C1c2ccc(Br)cc2NC2(CCNCC2)N1c1ccc(Cl)cc1,,Cc1ccccc1,,O,,val
US20040097555A1,Cc1cc(C)cc(-c2nc(N)sc2-c2ccncc2)c1.O=C(Cl)c1ccncc1>>Cc1cc(C)cc(-c2nc(NC(=O)c3ccncc3)sc2-c2ccncc2)c1,CN(C)c1ccncc1,CC(=O)N(C)C,,Cl,O=C([O-])O.[Na+],val
US20050176702A1,Brc1ccc2c(c1)CCN2.O=C(Cl)C=Cc1cccc(Cl)c1>>O=C(/C=C/c1cccc(Cl)c1)N1CCc2cc(Br)ccc21,,ClCCl,,CCN(CC)CC,O,val
US20120004221A1,CCNC(=O)Nc1nc2cc(Br)nc(Br)c2s1.CN(C)C=O.OB(O)c1cccnc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCNC(=O)Nc1nc2cc(-c3cccnc3)nc(-c3cccnc3)c2s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20100085531A1,C=CCC[C@@H](C)Oc1ccc(-c2ccc(O)cc2)cc1[N+](=O)[O-].CCCCCCCCCCCCc1ccc(C(=O)O)cc1>>C=CCC[C@@H](C)Oc1ccc(-c2ccc(OC(=O)c3ccc(OCCCCCCCCCCCC)cc3)cc2)cc1[N+](=O)[O-],CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US20120028989A1,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.O=C(OCc1ccccc1)N1CCNCC1>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCN(C(=O)OCc2ccccc2)CC1,,ClCCl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100261728A1,CI.O=C(Nc1ccccc1)N1CCc2ccccc2C1c1ccc(C(F)(F)F)cc1>>CN(C(=O)N1CCc2ccccc2C1c1ccc(C(F)(F)F)cc1)c1ccccc1,,C1CCOC1,,O,[H-].[Na+],val
US20030027862A1,CCOC(=O)C(=O)Nc1cc(C)c(Oc2ccc(O)c(CN(Cc3ccccc3)C(C)C)c2)c(C)c1>>Cc1cc(NC(=O)C(=O)O)cc(C)c1Oc1ccc(O)c(CN(Cc2ccccc2)C(C)C)c1,,C1COCCO1,O,[Na+].[OH-],,val
US20130288137A1,COc1cc2c(cc1OC)C(C)(C)CCC2(C)C>>CC1(C)CCC(C)(C)c2cc(O)c(O)cc21,,ClCCl,,BrB(Br)Br,,val
US20130344030A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@@H](N)c1ccc2ccc(Br)cc2n1>>C[C@@H](NC(=O)OC(C)(C)C)c1ccc2ccc(Br)cc2n1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,Cl,val
US04223143,Cc1ccc2nc[nH]c(=O)c2c1[N+](=O)[O-]>>Cc1ccc2nc[nH]c(=O)c2c1N,,CCO,CN(C)C=O,NN,,val
US20120329780A1,CN1CCN(c2ccc(N)cc2)CC1.COc1ccc(Cn2cc3nc(-c4cccc(S(F)(F)(F)(F)F)c4)nc(Cl)c3n2)cc1>>CN1CCN(c2ccc(Nc3nc(-c4cccc(S(F)(F)(F)(F)F)c4)nc4cn[nH]c34)cc2)CC1,C1COCCO1,CO,,Cl,,val
US04062952,CC(C)c1cccc([N+](=O)[O-])c1>>CC(C)c1cccc(N)c1,[Fe],CCO,,Cl,[Na+].[OH-],val
US20060128807A1,Cc1cc(-c2ccc(C(=O)O)cc2)cc(C)c1OCCN[C@@H](C)[C@H](O)c1ccc(O)cc1.Cl>>Cc1cc(-c2ccc(C(=O)O)cc2)cc(C)c1OCCN[C@@H](C)[C@H](O)c1ccc(O)cc1.Cl,,C1COCCO1,CCOCC,,,val
US20040248896A1,COc1cc(-c2oc(C(C)(C)C#N)cc2-c2ccncc2)ccc1Cl>>CC(C)(C#N)c1cc(-c2ccncc2)c(-c2ccc(Cl)c(O)c2)o1,,ClCCl,,BrB(Br)Br,,val
US20140228343A1,Nc1cccc(Br)c1.c1ccc2c(c1)CCN(CC1CO1)C2>>OC(CNc1cccc(Br)c1)CN1CCc2ccccc2C1,,CCO,,,,val
US20160176865A1,Brc1cnc2[nH]ccc2c1.CCCS(=O)(=O)Nc1cccc(C=O)c1F>>CCCS(=O)(=O)Nc1cccc(C(=O)c2c[nH]c3ncc(Br)cc23)c1F,,CO,,O,[K+].[OH-],val
US20120115840A1,CCc1cc(C(C)=NOCc2ccc(C3CCCCC3)c(C(F)(F)F)c2)ccc1C=O.O=C(O)C1CNC1>>CCc1cc(/C(C)=N/OCc2ccc(C3CCCCC3)c(C(F)(F)F)c2)ccc1CN1CC(C(=O)O)C1,,CO,,[Na+].[OH-],,val
US20110112127A1,COc1ccc(CN(C(=O)OC(C)(C)C)c2ncc(C(O)c3c[nH]c4ncc(C)cc34)cc2OC)cc1>>COc1cc(Cc2c[nH]c3ncc(C)cc23)cnc1N,,CC#N,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20120202785A1,Cc1ccc(F)c([N+](=O)[O-])c1.Nc1ccccc1>>Cc1ccc(Nc2ccccc2)c([N+](=O)[O-])c1,,CS(C)=O,,,,val
US20070082912A1,CC(=O)CCC(=O)c1cc(Cl)ccc1OCc1cccc(F)c1F.COC(=O)c1cc(N)ccc1NC(C)=O>>COC(=O)c1cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2cccc(F)c2F)ccc1NC(C)=O,,CC#N,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100113440A1,C=CC1CC1(NC(=O)C1CC(Oc2cc(C(C)(C)C)nc(OC)n2)CC1C(=O)OC(C)(C)C)C(=O)OCC>>C=CC1CC1(NC(=O)C1CC(Oc2cc(C(C)(C)C)nc(OC)n2)CC1C(=O)O)C(=O)OCC,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20150353563A1,CCOC(=O)/C([O-])=C/C(=O)C(C)C.Cc1cc(Cl)ccc1C=O.Nc1cccc(Cl)c1F>>Cc1cc(Cl)ccc1C1C(C(=O)C(C)C)=C(O)C(=O)N1c1cccc(Cl)c1F,,CC(=O)O,,,,val
US05521170,NO.O=C1CCNC(C(=O)c2ccc([N+](=O)[O-])cc2)c2ccccc21>>O=C(c1ccc([N+](=O)[O-])cc1)N1CCCC(=NO)c2ccccc21,,CCO,,Cl,c1ccncc1,val
US20090239845A1,Cc1cc(N(CC[Si](C)(C)C)C(=O)[O-])nn1Cc1cc(Cl)ccc1OCC(C)C>>Cc1cc(N)nn1Cc1cc(Cl)ccc1OCC(C)C,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20030065179A1,CC(C)(C)OC(=O)N1CCc2nc(-c3ccccc3)ncc2C1.Cl>>Cl.c1ccc(-c2ncc3c(n2)CCNC3)cc1,,CCOC(C)=O,,,,val
US20110201604A1,CNC(=O)c1ccc([N+](=O)[O-])c(NC)c1>>CNC(=O)c1ccc(N)c(NC)c1,[Pd],,,,,val
US20160024016A1,CNCCN(C)C(=O)OC(C)(C)C.Cn1cc(C=O)c(C2=CCC3(CC2)CC(C)(C)CO3)n1>>CN(CCN(C)C(=O)OC(C)(C)C)Cc1cn(C)nc1C1=CCC2(CC1)CC(C)(C)CO2,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20130225524A1,COC(=O)c1cccc(Nc2c(C(N)=O)cnc3cc(Cl)c(OC)cc23)c1.OB(O)c1ccncc1>>COC(=O)c1cccc(Nc2c(C(N)=O)cnc3cc(-c4ccncc4)c(OC)cc23)c1,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20150038438A1,C=CC(O)c1ccc(Br)cc1OCC(=C)C>>CC1=CC(O)c2ccc(Br)cc2OC1,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,ClCCl,,,,val
US20030225283A1,CS(=O)(=O)c1ccc(C(CC2CCCC2=O)C(=O)Nc2cnccn2)cc1Cl.NO>>CS(=O)(=O)c1ccc(C(CC2CCCC2=NO)C(=O)Nc2cnccn2)cc1Cl,,CO,c1ccncc1,Cl,,val
US06878700B1,COC(=O)C1CN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(C(F)(F)F)c2)CCN1C(=O)OC>>COC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(C(F)(F)F)c2)CC1C(=O)O,,O,,CCO,[Na+].[OH-],val
US20160263122A1,COc1ccc(N)cc1NC(=O)CN1CCOCC1.O=C(O)c1ccc(-c2ccccc2)[nH]1>>COc1ccc(NC(=O)c2ccc(-c3ccccc3)[nH]2)cc1NC(=O)CN1CCOCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04265990,CS(C)=O.Cc1cccc(I)c1.c1ccc(Nc2ccc(-c3ccc(Nc4ccccc4)cc3)cc2)cc1.c1ccccc1>>Cc1cccc(N(c2ccccc2)c2ccc(-c3ccc(N(c4ccccc4)c4cccc(C)c4)cc3)cc2)c1,[Cu],,,O=C([O-])[O-].[K+].[K+],,val
US20120040020A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ncc(Br)nc1-c1nnc(-c2ccccc2)o1.OC1CC[C@H]2CNC[C@@H]12>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ncc(N2C[C@@H]3CCC(O)[C@@H]3C2)nc1-c1nnc(-c2ccccc2)o1,,CN(C)C=O,,CCN(CC)CC,,val
US05312820,CCCCNCc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1.O=C(Cl)Cl>>CCCCN(Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1)C(=O)Cl,,Cc1ccccc1,,[Na+].[OH-],,val
US20160016948A1,C[C@@H](N)CC(F)(F)F.O=[N+]([O-])c1cnc(Cl)cc1Cl>>C[C@@H](Nc1cc(Cl)ncc1[N+](=O)[O-])C(F)(F)F,,C1CCOC1,O,CCN(CC)CC,,val
US20090054464A1,CCOC(=O)/C=C/c1cnc(N[C@@H]2CCCN(Cc3cccc(Cl)c3)C2)cn1>>O=C(O)/C=C/c1cnc(N[C@@H]2CCCN(Cc3cccc(Cl)c3)C2)cn1,,CCO,,Cl,[Na+].[OH-],val
US05075299,CN(C)C=O.COc1ccc(CCl)cc1.Cc1oc(O)cc(=O)c1O>>COc1ccc(COc2c(C)oc(CO)cc2=O)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100029621A1,C[C@H]1CNCCN1.OC(c1ccc(CBr)cc1)(C(F)(F)F)C(F)(F)F>>C[C@H]1CN(Cc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)CCN1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20010051631A1,Cc1nc2cccc3n(CCCCCCN)c(=O)c1n23.O=S(=O)(Cl)CC(F)(F)F>>Cc1nc2cccc3n(CCCCCCNS(=O)(=O)CC(F)(F)F)c(=O)c1n23,,ClCCl,,CCN(CC)CC,,val
US20100298336A1,Cc1cc(O)nc(S)n1.Cc1nc2ccccn2c1CBr>>Cc1cc(O)nc(SCc2c(C)nc3ccccn23)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140100231A1,CI.N#Cc1cc(Cl)cc(Oc2c(C(F)(F)F)ncn(Cc3cnc(O)cn3)c2=O)c1>>Cn1cc(Cn2cnc(C(F)(F)F)c(Oc3cc(Cl)cc(C#N)c3)c2=O)ncc1=O,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060046999A1,COc1ccc(C(=O)CC#N)cc1.Nc1ccccc1>>COc1ccc(C(=O)CC(=N)Nc2ccccc2)cc1,,CCO,,,,val
US06376701B1,CC1CCC(C(C)C)C(O)C1.COC(=O)CC(C)=O>>CC(=O)CC(=O)OC1CC(C)CCC1C(C)C,,Cc1ccccc1,,,,val
US20020016333A1,CCOS(=O)(=O)OCC.O=C(c1ccccc1Cl)c1c(O)nn(-c2c(Cl)cc(Cl)cc2Cl)c1N1C(=O)c2ccccc2C1=O>>CCOc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(N2C(=O)c3ccccc3C2=O)c1C(=O)c1ccccc1Cl,,CS(C)=O,,O,[H-].[Na+],val
US20090124624A1,CCCCCC.CON(C)C(=O)C1CCN(Cc2ccccc2)CC1.COc1ccc(Br)c(C(=O)O)c1>>CCOc1ccc(C(=O)C2CCN(Cc3ccccc3)CC2)c(C(=O)O)c1,,C1CCOC1,CCCCCC,O,[Li]CCCC,val
US20090121625A1,COB(OC)OC.COc1ccc2ccccc2c1>>COc1cc2ccccc2cc1B(O)O,,C1CCOC1,ClC(Cl)Cl,Cl,[Li]CCCC,val
US06110638,Cc1ccc(S(=O)(=O)Cl)cc1.Cc1ccc([C@@]2(O)CC3CCC2[C@H]3O)cc1>>Cc1ccc([C@@]2(O)CC3CCC2[C@H]3OS(=O)(=O)c2ccc(C)cc2)cc1,,c1ccncc1,,O=C([O-])O.[Na+],,val
US20110244481A1,CC(C)(C)[Si](C)(C)Oc1ccc(-c2cnc(N)c(-c3cc4sccc4s3)n2)cc1.CC(C)(C)[Si](C)(C)Oc1ccc(CC(=O)Cl)cc1>>CC(C)(C)[Si](C)(C)Oc1ccc(CC(=O)Nc2ncc(-c3ccc(O[Si](C)(C)C(C)(C)C)cc3)nc2-c2cc3sccc3s2)cc1,CN(C)c1ccncc1,c1ccncc1,,O,,val
US20130023541A1,CC(C)OC(=O)c1cccnc1N1CC[C@H](N)C1.Cc1cc(C=O)sc1C>>Cc1cc(CN[C@H]2CCN(c3ncccc3C(=O)OC(C)C)C2)sc1C,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110105544A1,CC(=O)OCBr.O=C(O)C(CCCc1ccccc1)CCc1ccc(OCc2ccccc2)cc1>>CC(=O)OCOC(=O)C(CCCc1ccccc1)CCc1ccc(OCc2ccccc2)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20020055507A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc(C(C)(C)C)cc1[N+](=O)[O-]>>Cc1ccc(C(C)(C)C)cc1NC(=O)OC(C)(C)C,[Pd],CN(C)C=O,,,,val
US04377634,CC(C)(C)CC(C)(C)C1=CC(=O)C=CC1=O.CCCCCc1nnc(S)n1-c1ccccc1>>CCCCCc1nnc(Sc2cc(O)c(C(C)(C)CC(C)(C)C)cc2O)n1-c1ccccc1,,CO,,,,val
US05663271,C[Si](C)(C)Cl.[Li][Si](C)(C)c1ccccc1.c1ccc([Si]2(c3ccccc3)[Si](c3ccccc3)(c3ccccc3)[Si](c3ccccc3)(c3ccccc3)[Si]2(c2ccccc2)c2ccccc2)cc1>>C[Si](C)(C)[Si](c1ccccc1)(c1ccccc1)[Si](c1ccccc1)(c1ccccc1)[Si](c1ccccc1)(c1ccccc1)[Si](c1ccccc1)(c1ccccc1)[Si](C)(C)c1ccccc1,,C1CCOC1,CCCCCC,O=C([O-])O.[Na+],,val
US20100240669A1,Cc1cccc(C(F)(F)F)c1N.N#Cc1ccc(F)cn1>>Cc1cccc(C(F)(F)F)c1Nc1ccc(CN)nc1,[Ni],,,,,val
US20020007071A1,CC(C)(C)OC(=O)N1CCCC(CCCOc2cccc3c2nc(COc2ccc(Cl)cc2)n3CCCC2CCCN(C(=O)OC(C)(C)C)C2)C1.Clc1ccc(OCc2nc3cccc(OCc4ccccc4)c3[nH]2)cc1>>CC(C)(C)OC(=O)N1CCCC(CCn2c(COc3ccc(Cl)cc3)nc3c(OCc4ccccc4)cccc32)C1,,CN(C)C=O,,[H-].[Na+],,val
US05026856,COC(=O)c1cccc2c1CN(Cc1ccccc1)C2>>O=C(O)c1cccc2c1CN(Cc1ccccc1)C2,,O,,[Na+].[OH-],,val
US20090093485A1,CC(=O)CC(C)=O.NNc1ccc(F)cc1>>Cc1cc(C)n(-c2ccc(F)cc2)n1,,CCO,,Cl,,val
US20030212111A1,CCNc1ccc(C#N)cc1NC(=S)NCc1ccccc1.CCOC(=O)CCl>>CCNc1ccc(C#N)cc1N=C1SCC(=O)N1Cc1ccccc1,,CCO,,C1CCC2=NCCCN2CC1,,val
US05536721,CC(=O)c1c(Cl)n(C)c2ccccc12.COC(=O)CS>>COC(=O)c1sc2c(c1C)c1ccccc1n2C,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US20060172983A1,CC(=O)Nc1ccc(OC(=O)COCc2ccccc2)cc1>>CC(=O)Nc1ccc(OC(=O)CO)cc1,[Pd],CO,,,,val
US20030119721A1,CCOC(=O)C(F)(F)Br.O=Cc1ccccc1[N+](=O)[O-]>>CCOC(=O)C(F)(F)C(O)c1ccccc1[N+](=O)[O-],[Zn],C1CCOC1,CCOC(C)=O,,,val
US20120232050A1,CC(=O)OC(C)=O.C[C@@H](c1ccc(C#CC2(N)CCCCC2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O>>CC(=O)NC1(C#Cc2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)CCCCC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05234946,O=Cc1cccc(S)c1.OCc1cccc(CBr)c1>>O=Cc1cccc(SCc2cccc(CO)c2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060154926A1,CCCCNC(=O)[C@H](C)C[C@H](O)[C@H](C[C@H](Cc1ccc(OC)c(OCc2ccccc2)c1)C(C)C)NC(=O)OC(C)(C)C>>CCCCNC(=O)[C@H](C)C[C@H](O)[C@H](C[C@H](Cc1ccc(OC)c(O)c1)C(C)C)NC(=O)OC(C)(C)C,[Pd],CO,,,,val
US20110105463A1,CC1(C)CC(C(=O)O)c2ccc(F)cc2O1.CO>>COC(=O)C1CC(C)(C)Oc2cc(F)ccc21,,CO,ClCCl,C[Si](C)(C)C=[N+]=[N-],,val
US20100216802A1,CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4C5CN(CC[C@H](NC(=O)OC(C)(C)C)C(=O)OC6CCCC6)CC54)cc3OC)nc2N1C1CCCC1>>CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4C5CN(CC[C@H](N)C(=O)OC6CCCC6)CC54)cc3OC)nc2N1C1CCCC1,,C1COCCO1,Cl,,,val
US20050197362A1,CI.O=c1[nH]c2cccc3c2n1CCC3>>Cn1c(=O)n2c3c(cccc31)CCC2,,CN(C)C=O,,O,[H-].[Na+],val
US20160031892A1,CC(C)(C)OC(=O)N1CC(=O)C1.C[Si](C)(C)C#N>>CC(C)(C)OC(=O)N1CC(C#N)(O[Si](C)(C)C)C1,,ClCCl,,CCN(CC)CC,,val
US20090069326A1,N[C@H]1CC[C@H](O)CC1.O=CC[C@@H](Cc1c(Cl)cc(OCc2ccccc2)cc1Cl)C(=O)N1C(=O)OC[C@H]1Cc1ccccc1>>O=C1[C@H](Cc2c(Cl)cc(OCc3ccccc3)cc2Cl)CCN1[C@@H]1CC[C@@H](O)CC1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140011800A1,CC1C(N)CC2CN(C(=O)OC(C)(C)C)CC21.NC(=O)c1cnn2cc(Br)cc2c1Cl>>C[C@H]1[C@H](Nc2c(C(N)=O)cnn3cc(Br)cc23)C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]12,,CCOC(C)=O,CN1CCCC1=O,CCN(C(C)C)C(C)C,,val
US20150126492A1,CC(C)(C)OC(=O)N[C@H](CC(=O)N1CCNCC1)c1ccc(F)cc1.COc1cc2nc(Cl)nc(N)c2c(F)c1OC>>COc1cc2nc(N3CCN(C(=O)C[C@@H](NC(=O)OC(C)(C)C)c4ccc(F)cc4)CC3)nc(N)c2c(F)c1OC,,CC(C)CCO,,CCN(CC)CC,,val
US06423689B1,CC(C)(C)OC(=O)[C@@H](N)Cc1ccc(O)cc1.O=C(OCC1c2ccccc2-c2ccccc21)ON1C(=O)CCC1=O>>CC(C)(C)OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21,,C1COCCO1,O,,,val
US20120122863A1,CCOC(=O)[C@H](c1ccc(Cl)cc1)n1c(=O)c2ccccc2n(Cc2nsc3cc(C)cc(C)c23)c1=O>>Cc1cc(C)c2c(Cn3c(=O)n([C@H](C(=O)O)c4ccc(Cl)cc4)c(=O)c4ccccc43)nsc2c1,,C1COCCO1,O,[Li+].[OH-],,val
US20110052674A1,CCCCc1nc(Cl)c(C(=O)N[C@@H](Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1.O=[N+]([O-])OC[C@@H](CCCCO)O[N+](=O)[O-]>>CCCCc1nc(Cl)c(C(=O)N[C@@H](Cc2ccccc2)C(=O)OCCCC[C@H](CO[N+](=O)[O-])O[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20080039444A1,Cc1ccc(S(=O)(=O)OCCCNC(=O)OC(C)(C)C)cc1.O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCNCC1>>CC(C)(C)OC(=O)NCCCN1CCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1,,CC(C)=O,,CCN(C(C)C)C(C)C,[I-].[Na+],val
US20160102083A1,COC(=O)c1ccc(N)s1.O=C1CCOCC1>>COC(=O)c1ccc(NC2CCOCC2)s1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04382142,CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.Nc1nncs1>>CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1nncs1,,ClC(Cl)Cl,,CCN(CC)CC,CCOC(=O)Cl,val
US20090324581A1,CC(O)=CC(O)(N1CCCC1)C(F)(F)F.NNc1ccccc1>>Cc1cc(C(F)(F)F)n(-c2ccccc2)n1,,C1CCOC1,,,,val
US20080085890A1,C/C(O)=C1/C(=O)NC(=O)CC1c1ccccc1.COc1ccc(CN)cc1O>>COc1ccc(CN/C(C)=C2\C(=O)NC(=O)CC2c2ccccc2)cc1O,,CCO,,CC(=O)[O-].[Na+],,val
US20150111870A1,COCCO.COc1nc2ccc(C(O)(c3ccc(C(F)(F)F)nc3)c3cncn3C)cc2c(Cl)c1O>>COCCOc1c(OC)nc2ccc(C(O)(c3ccc(C(F)(F)F)nc3)c3cncn3C)cc2c1Cl,,COCCO,,,,val
US20050187390A1,COc1cc(Br)c2oc(C(C)=O)cc2c1.O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4cc(Br)ccc4O)ccc3c1)n2C1CCCCC1>>COc1cc(Br)c2oc(-c3ccc4cc(-c5nc6cc(C(=O)O)ccc6n5C5CCCCC5)ccc4n3)cc2c1,,CCO,,[K+].[OH-],,val
US06204264B1,NCCCn1ccnc1.O=[N+]([O-])c1ccccc1Cl>>O=[N+]([O-])c1ccccc1NCCCn1ccnc1,,CCOC(C)=O,,,,val
US06525069B1,Cn1nnnc1-c1ccc(N)cc1.O=C(Cl)Oc1ccccc1>>Cn1nnnc1-c1ccc(NC(=O)Oc2ccccc2)cc1,,C1CCOC1,,CCN(CC)CC,CCOC(C)=O,val
US20100056434A1,C=CCOC(=O)C[C@H](O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)C[C@H](O)/C=C/CCSC(c1ccccc1)(c1ccccc1)c1ccccc1>>O=C(O)C[C@H](O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)C[C@H](O)/C=C/CCSC(c1ccccc1)(c1ccccc1)c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,ClCCl,C1COCCN1,,val
US05714496,CC(=O)Cl.NC(=NO)c1ccc(I)cc1>>Cc1nc(-c2ccc(I)cc2)no1,,c1ccncc1,,,,val
US20150259350A1,Clc1ncc(Br)cn1.Cn1cc(-c2cnc3nnn(C[C@@H]4CN(C(=O)OC(C)(C)C)CCO4)c3n2)cn1>>Cn1cc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(Br)cn5)CCO4)c3n2)cn1,,CCO,,CCN(C(C)C)C(C)C,,val
US20040132727A1,CC(C)N(CCN)C(C)C.COc1cc(Oc2ncnc3cc(OC)c(OC)cc23)ccc1N.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc(Oc2ncnc3cc(OC)c(OC)cc23)ccc1NC(=O)NCCN(C(C)C)C(C)C,,ClC(Cl)Cl,O,CCN(CC)CC,,val
US20060128664A1,BrCCCCCCCCCCBr.C1CCOC1.CN(C)C>>C[N+](C)(C)CCCCCCCCCCBr.[Br-],,C1CCOC1,,,,val
US20010051733A1,CC(=O)Cl.Cc1ccc(Cl)c2c1SCCC2(C)C>>CC(=O)c1cc(C)c2c(c1Cl)C(C)(C)CCS2,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20090233907A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(C3CCSC3)c2=O)CC1.Cl>>Cl.N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(C3CCSC3)c2=O)CC1,,C1COCCO1,,,,val
US20020115692A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@@H](N)Cc1c[nH]c2ccccc12>>COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C,,C1COCCO1,O,Cl,O=C([O-])O.[Na+],val
US06919328B1,Nc1ccc2c(c1)C(=O)Nc1ccccc1N2.O=C(N=C=S)c1ccccc1>>O=C(NC(=S)Nc1ccc2c(c1)C(=O)Nc1ccccc1N2)c1ccccc1,,C1CCOC1,,,,val
US20030153568A1,CCNC(=O)Nc1nc2ccc(C(=O)CCN)cc2s1.O=C(Cl)c1ccccc1>>CCNC(=O)Nc1nc2ccc(C(=O)CCNC(=O)c3ccccc3)cc2s1,,CN(C)C=O,,CCN(CC)CC,,val
US20080167307A1,CCCCCCCN(CCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1)c1ncc(C(N)=O)cc1Cl>>CCCCCCCN(CCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1)c1ncc(C#N)cc1Cl,,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20110098297A1,COCc1ccc(Oc2cc(OC)c3[nH]c(C(N)=O)cc3c2)cn1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COCc1ccc(Oc2cc(OC)c3[nH]c(C(N)=S)cc3c2)cn1,,C1CCOC1,,,,val
US20030045560A1,BrBr.CCCCc1oc2ccccc2c1C(=O)N(C)Cc1ccc2cc(O)ccc2c1>>CCCCc1oc2ccccc2c1C(=O)N(C)Cc1ccc2c(Br)c(O)ccc2c1,,CC(=O)O,,,,val
US20080064740A1,CCc1sc(C(=O)O)c2c1C1C(C2)C1(C)C.[Li]C>>CCc1sc(C(C)=O)c2c1[C@H]1[C@@H](C2)C1(C)C,,CCOCC,,,,val
US20010037030A1,O=C(Cl)OCc1ccccc1.O=C1CC[C@@H]2CN(Cc3ccccc3)C[C@H]12>>O=C1CC[C@@H]2CN(C(=O)OCc3ccccc3)C[C@H]12,,ClCCl,,,,val
US20130317001A1,O=C(NS(=O)(=O)N1CCC1)c1cc(Cl)c(F)cc1F.OCC1CC12CCCCC2>>O=C(NS(=O)(=O)N1CCC1)c1cc(Cl)c(OCC2CC23CCCCC3)cc1F,,CS(C)=O,,Cl,CC(C)(C)[O-].[K+],val
US20140364446A1,CC(C)OC(=O)[C@@H](C)N.O=P(Cl)(Cl)Oc1ccccc1.Oc1c(F)c(F)c(F)c(F)c1F>>CC(C)OC(=O)[C@@H](C)NP(=O)(Oc1ccccc1)Oc1c(F)c(F)c(F)c(F)c1F,,ClCCl,,CCN(CC)CC,Cl,val
US05106871,COC(=O)CBr.COCOc1c(OC)cc(CCC(=O)c2c(OC)cc(OC)c(CCC(C)C)c2O)cc1OC>>COCOc1c(OC)cc(CCC(=O)c2c(OC)cc(OC)c(CCC(C)C)c2OCC(=O)OC)cc1OC,,CN(C)C=O,,[H-].[Na+],,val
US04195021,CC(COC=O)=C(C(=O)OC(c1ccccc1)c1ccccc1)N1CC(NC(=O)COc2ccccc2)C1=O>>CC(CO)=C(C(=O)OC(c1ccccc1)c1ccccc1)N1CC(NC(=O)COc2ccccc2)C1=O,,C1CCOC1,,CCOC(C)=O,[Na+].[OH-],val
US05393734,CCCCOC=CC(=O)C(F)(F)F.CCOC(=O)CC(N)=O>>COC(=O)c1ccc(C(F)(F)F)[nH]c1=O,,CO,O,Cl,C[O-].[Na+],val
US20150197512A1,CI.OCc1ccc(Br)s1>>COCc1ccc(Br)s1,,C1CCOC1,,Cl,[H-].[Na+],val
US20050004142A1,COc1cccc(CC(=O)O)c1.NC1=c2ccoc2=NCN1c1ccc(N)cc1>>COc1cccc(CC(=O)Nc2ccc(N3CN=c4occc4=C3N)cc2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120130129A1,COc1ccc(/C=C/CCC(=O)O)c(OC)c1OC>>COc1ccc(CCCCC(=O)O)c(OC)c1OC,[Pd],CO,,,,val
US20100216814A1,C=CCBr.CN1CCc2[nH]c3ccc(Cl)cc3c2C1>>C=CCn1c2c(c3cc(Cl)ccc31)CN(C)CC2,,CN(C)C=O,,CO,[H-].[Na+],val
US20160052898A1,COc1ccc([N+](=O)[O-])cc1N.O=C(Cl)CCl>>COc1ccc([N+](=O)[O-])cc1NC(=O)CCl,,ClCCl,,c1ccncc1,,val
US05882543,CCOC(=O)CC(=O)c1ccccc1.C[Si](C)(C)N[Si](C)(C)C>>COC(=CC(=O)c1ccccc1)O[Si](C)(C)C,,CCOCC,,N,,val
US20150376208A1,CCOC(=O)C(CC)C(=O)OC.Nc1ccn[nH]1>>Cc1c(O)nc2ccnn2c1O,,CCO,,[Na],,val
US20160272621A1,COC(=O)c1ccnc(Nc2ccc(C(C)(C)C#N)cn2)c1>>CC(C)(C#N)c1ccc(Nc2cc(C(=O)O)ccn2)nc1,,C1CCOC1,CO,[Li+].[OH-],,val
US20140038975A1,CCOC(=O)[C@@](C)(CCn1cc(I)cn1)S(C)(=O)=O.OB(O)C1=CCCC1>>CCOC(=O)[C@@](C)(CCn1cc(C2=CCCC2)cn1)S(C)(=O)=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US04145546,COc1ccccc1Cc1cnc(SC)[nH]c1=O.Cc1[nH]cnc1CSCCN>>COc1ccccc1Cc1cnc(NCCSCc2nc[nH]c2C)[nH]c1=O,,CCO,,,,val
US06362177B1,CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2cc3c(cc2[N+](=O)[O-])OCO3)C1>>CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2cc3c(cc2N)OCO3)C1,[Pd],CO,,,,val
US20140296245A1,CCOC(=O)[C@@H]1CNCC[C@H]1c1ccc(Cl)cc1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CCOC(=O)[C@@H]1CN(CC(F)(F)F)CC[C@H]1c1ccc(Cl)cc1,,CC(C)=O,,CCN(CC)CC,,val
US20050187390A1,COC(=O)c1ccc(N)c(C=O)c1.O=C(O)c1ccc2nc(-c3cc(C(=O)N4CCCC4)ccc3-c3ccc(Cl)cc3)ccc2c1>>COc1ccc(-c2ccc(Cl)cc2)c(-c2ccc3cc(C(=O)O)ccc3n2)c1,,CCO,,[K+].[OH-],,val
US20080076924A1,Cc1ccccc1NC(=NC#N)N1CCNC(c2ccccc2)C1.ClCc1ccc(Cl)cc1>>Cc1ccccc1NC(=NC#N)N1CCN(Cc2ccc(Cl)cc2)C(c2ccccc2)C1,,CC#N,,CCN(CC)CC,,val
US20130217680A1,C=C(C)Cc1ccc2c(c1)COC2=O.O=[Os](=O)(=O)=O>>CC(=O)Cc1ccc2c(c1)COC2=O,O=[Os](=O)(=O)=O,C1CCOC1,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US06417183B1,CN1CCCNCC1.ClC1CCCc2cc(Br)ccc21>>CN1CCCN(C2CCCc3cc(Br)ccc32)CC1,,CN(C)C=O,,[I-].[K+],,val
US20160152599A1,CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3c(cc2-n2cc(C(=O)N(c4ccc(O[Si](C)(C)C(C)(C)C)cc4)c4ccc5c(ccn5C(=O)OC(C)(C)C)c4)c4ccccc42)OCO3)CC1>>CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3c(cc2-n2cc(C(=O)N(c4ccc(O)cc4)c4ccc5[nH]ccc5c4)c4ccccc42)OCO3)CC1,,CO,,[K+].[OH-],,val
US20010049441A1,O=S(=O)(Cl)c1ccccc1.c1cc2[nH]cc(C3CCN4CCCC4C3)c2cn1>>O=S(=O)(c1ccccc1)n1cc(C2CCN3CCCC3C2)c2cnccc21,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20070269494A1,CCCCCCNC(=O)c1cc(O)ccc1O.O=C1CCC(=O)O1>>CCCCCCNC(=O)c1cc(OC(=O)CCC(=O)O)ccc1O,,ClCCl,,,,val
US05366972,CCNc1ncccc1C(=O)N(C)c1ccc(OC)nc1Br>>CCN1c2ncccc2C(=O)N(C)c2ccc(OC)nc21,,Cc1ccccc1C,,[H-].[Na+],,val
US20160208027A1,CCN(CC)C(=O)OC(C)CC(C)O.O=C(Cl)c1ccccc1>>CCN(CC)C(=O)OC(C)CC(C)OC(=O)c1ccccc1,,C1CCOC1,,c1ccncc1,,val
US20130338066A1,CC1(C)OC(N[C@@H](CCO[Si](C)(C)C(C)(C)C)c2ccccc2)=NS(=O)(=O)C1c1cccc(OCc2ccccc2)c1>>CC1(C)OC(N[C@@H](CCO)c2ccccc2)=NS(=O)(=O)C1c1cccc(OCc2ccccc2)c1,,CO,,Cl,,val
US20080275043A1,CC1(N2CCC(Cc3ccc(Cl)cc3Cl)C2=O)CCC(O)CC1.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>CC1(N2CCC(Cc3ccc(Cl)cc3Cl)C2=O)CCC(OC(=O)c2ccc([N+](=O)[O-])cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20050148623A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](C[C@H](Cc1ccc(-c2cccnc2)cc1)NC(=O)OCc1ccccc1)O[Si](C)(C)C(C)(C)C>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccc(-c2cccnc2)cc1)NC(=O)OCc1ccccc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040210080A1,CCCCC12CCC(=O)C(C)=C1c1cc(F)c(N)cc1C2.O=C1CCC(=O)N1Br>>CCCCC12CCC(=O)C(C)=C1c1cc(F)c(N)c(Br)c1C2,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040209897A1,C=CCBr.O=C1NCCc2[nH]c(-c3ccnc(Cl)c3)cc21>>C=CC[n+]1ccc(-c2cc3c([nH]2)CCNC3=O)cc1Cl.[Br-],,CN(C)C=O,,,,val
US04814485,COC(=O)C[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c1ccccc1.ClCCl.O=C(O)C(F)(F)F.On1nnc2ccccc21>>CCCC[C@H](NC(=O)OC(C)(C)C)C(=O)NC(c1ccccc1)C(O)CC(=O)OC,,ClCCl,,,,val
US20110046147A1,COc1cccc(-c2cc(Br)cs2)c1.COc1cccc(B(O)O)c1>>COc1cccc(-c2csc(-c3cccc(OC)c3)c2)c1,,CCCCCC,CCOC(C)=O,,,val
US20050239814A1,CCOC(=O)C(C(=O)OCC)c1ccc([N+](=O)[O-])c(N)c1C(=O)OC>>CCOC(=O)C(C(=O)OCC)c1ccc(N)c(N)c1C(=O)OC,[Pd],CCOC(C)=O,CO,,,val
US06350749B1,COc1ccc(Cl)cc1C1CC(=O)c2c(C)ccnc2C1>>Cc1ccnc2c1C(=O)CC(c1cc(Cl)ccc1O)C2,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20100273764A1,CC(C)(C)OC(=O)Nc1cc(N=C(c2ccccc2)c2ccccc2)cnc1Cl>>CC(C)(C)OC(=O)Nc1cc(N)cnc1Cl,,C1CCOC1,,Cl,,val
US20090209607A1,N#CCC(=O)O.O=C(Cl)Cc1ccccc1>>N#CCC(=O)Cc1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20130096301A1,Brc1ccc(CN2CCOCC2)cc1.C=CB1OC(C)(C)C(C)(C)O1>>CC1(C)OB(/C=C/c2ccc(CN3CCOCC3)cc2)OC1(C)C,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,Cc1ccccc1,,CCN(CC)CC,,val
US05721230,CC(C)[C@H](NC(=O)OC(C)(C)C)[C@H]1CCn2c(cc3ccccc32)C1.O=C(Cl)C(=O)Cl.O=C(O)Cc1cn(-c2ccccc2)c2ccccc12>>CC(C)[C@H](NC(=O)OC(C)(C)C)[C@H]1CCn2c(c(C3=C(c4cn(-c5ccccc5)c5ccccc45)C(=O)OC3=O)c3ccccc32)C1,,CCOCC,ClCCl,CCN(CC)CC,,val
US20070259877A1,C[Sn](C)(C)c1ccc(S(=O)(=O)Oc2ccccc2)s1.Cc1cccc(Br)n1>>Cc1cccc(-c2ccc(S(=O)(=O)Oc3ccccc3)s2)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN1CCCC1=O,O,,,val
US20060135578A1,Cc1sc(N2CCOCC2)nc1CCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1sc(N2CCOCC2)nc1[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Cl-],,CC#N,,,,val
US05686424,CC[C@H](C)[C@H](N)C(=O)NCc1ccccc1.Cc1c(C(=O)CCl)sc2ccc(Cl)cc12.O=C(O)[C@@H]1CCCN1>>CC[C@H](C)[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)c1sc2ccc(Cl)cc2c1C,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US07618996B2,CC(C)(C)OC(=O)N(CCC1CC1)Cc1ccc(Oc2ccc3c(c2)OC(C)(C)OC3=O)c(F)c1.N>>CC(C)(C)OC(=O)N(CCC1CC1)Cc1ccc(Oc2ccc(C(N)=O)c(O)c2)c(F)c1,,CC(C)O,,,,val
US05057614,CS(=O)(=O)OCCCn1cc(C2=C(c3ccccc3[N+](=O)[O-])C(=O)NC2=O)c2ccccc21.NC(N)=S>>CS(=O)(=O)O.N=C(N)SCCCn1cc(C2=C(c3ccccc3[N+](=O)[O-])C(=O)NC2=O)c2ccccc21,,CCO,,,,val
US20090163524A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC(CCO)c1ccc(Cl)cc1>>CC(C)(C)OC(=O)NC(CCO)c1ccc(Cl)cc1,,ClCCl,,,,val
US20010028888A1,CCOC(=O)C(C#N)=C(c1ccccc1)c1ccccc1.OC1CCCCC1>>N#CC(C(=O)OC1CCCCC1)=C(c1ccccc1)c1ccccc1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20130143926A1,C#CCCO.C#CCN(CC#C)C(=O)c1cc(C(=C)C)c(OCc2ccccc2)cc1OCc1ccccc1>>C=C(C)c1cc(C(=O)N2Cc3ccc(CCO)cc3C2)c(OCc2ccccc2)cc1OCc1ccccc1,,CCOC(C)=O,,CCCCCCC,,val
US20150087639A1,CCN(CC)c1ccc(-c2nccs2)cc1.O=[N+]([O-])O>>CCN(CC)c1ccc(-c2ncc([N+](=O)[O-])s2)cc1,,O=S(=O)(O)O,,,,val
US20140275030A1,Cc1noc(C)c1-c1cc(F)c2nc(Cl)n3c2c1OCC3c1cccnc1.OC1CCNC1>>Cc1noc(C)c1-c1cc(F)c2nc(N3CCC(O)C3)n3c2c1OCC3c1cccnc1,,CN1CCCC1=O,CO,CCN(CC)CC,,val
US20100016371A1,CC(C)(C)OC(=O)n1cc(C(OC(=S)Oc2ccccc2)C(F)(F)F)c2ccc(Cl)cc21>>CC(C)(C)OC(=O)n1cc(CC(F)(F)F)c2ccc(Cl)cc21,,Cc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US20070099944A1,II.O=[N+]([O-])c1ccc2[nH]ncc2c1>>O=[N+]([O-])c1ccc2[nH]nc(I)c2c1,,CN(C)C=O,,[K+].[OH-],,val
US05665754,COC(=O)Cl.COc1ccc([C@@H]2CN(Cc3ccccc3)C[C@H]2C(C)=O)cc1OC1CCCC1>>COC(=O)N1C[C@@H](C(C)=O)[C@H](c2ccc(OC)c(OC3CCCC3)c2)C1,,CC(Cl)Cl,,,,val
US20120270938A1,CCOC(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1>>CCOC(=O)c1cc(N)cc(C(=O)O)c1,[Pd],CO,,,,val
US20090298744A1,CCCn1c(=O)[nH]c(N)c(N)c1=O.O=C(O)c1cnn(CC2CC(=O)N(c3cccc(C(F)(F)F)c3)C2)c1>>CCCn1c(=O)[nH]c(N)c(NC(=O)c2cnn(CC3CC(=O)N(c4cccc(C(F)(F)F)c4)C3)c2)c1=O,,CO,,CCN=C=NCCCN(C)C,,val
US20110082294A1,COC(=O)[C@H](C)N(CC=O)C(=O)OCc1ccccc1.N[C@H](CO)CCN1CCC2(CC2)[C@H](O)C1>>C[C@H]1C(=O)N2C(CN1C(=O)OCc1ccccc1)OC[C@@H]2CCN1CCC2(CC2)[C@H](O)C1,,Cc1ccccc1,,,,val
US20140134235A1,CCOC(=O)c1[nH]c2ccccc2c1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1>>Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2c(C(=O)O)[nH]c3ccccc23)n1,,CCO,,[Na+].[OH-],,val
US05952321,CCC[C@@H](NC(=O)N1C(=O)C(CC)(CC)[C@@H]1Oc1ccc([C@H](C)N(C)C(=O)COC)cc1)c1ccc(C)cc1>>CCC[C@@H](NC(=O)N1C(=O)C(CC)(CC)[C@@H]1Oc1ccc([C@H](C)N(C)CCOC)cc1)c1ccc(C)cc1,,C1CCOC1,,B,CSC,val
US20130261178A1,CC(C)(C)OC(=O)NCCCC(=O)O.Oc1ccccc1>>CC(C)(C)OC(=O)NCCCC(=O)Oc1ccccc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20030220325A1,Fc1cccc2ccccc12.O=S(=O)(O)Cl>>O=S(=O)(Cl)c1ccc(F)c2ccccc12,,ClC(Cl)Cl,,O,,val
US20090286790A1,CCC1CC(Nc2ncc(OCc3ccccc3)cn2)CC(CC)N1C(=O)OC(C)C.FC(F)(F)c1cc(Cl)cc(CBr)c1>>CCC1CC(N(Cc2cc(Cl)cc(C(F)(F)F)c2)c2ncc(OCc3ccccc3)cn2)CC(CC)N1C(=O)OC(C)C,,CN(C)C=O,,O,[H-].[Na+],val
US20050049249A1,C=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](C)C/C(C)=C\[C@H](C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](C)/C=C\C(=O)CC1CCCC1.O=C=NC(=O)C(Cl)(Cl)Cl>>C=CC=CC(C)C(OC(N)=O)C(C)C(O[Si](C)(C)C(C)(C)C)C(C)CC(C)=CC(C)C(O[Si](C)(C)C(C)(C)C)C(C)C=CC(=O)CC1CCCC1,,ClCCl,,,,val
US04769366,C=CCN1CCN(C2=NC3(C=CC(=O)C=C3)C(c3ccccc3)=C2)CC1>>C=CCN1CCN(c2cc(-c3ccccc3)c3ccc(=O)ccn23)CC1,,ClCCl,,CCOC(C)=O,,val
US20130005710A1,CI.COc1ccc(N2CCNC(=O)CC2)c(-c2ccc(N(C)C)cc2)n1>>COc1ccc(N2CCC(=O)N(C)CC2)c(-c2ccc(N(C)C)cc2)n1,,O,,CN(C)C=O,[H-].[Na+],val
US20090156612A1,COC(=O)N[C@H]1CCCC[C@@H]1n1cnc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2Cc2ccccc2Br)c1-c1ccccc1>>COC(=O)N[C@H]1CCCC[C@@H]1n1cnc(C(=O)N2CCNC[C@H]2Cc2ccccc2Br)c1-c1ccccc1,,ClCCCl,,CC(Cl)OC(=O)Cl,,val
US05342846,Cc1cn(C2CCN(c3c(F)cc4c(=O)c(C(=O)O)cn(C5CC5)c4c3F)C2)nn1.NCCO>>Cc1cn(C2CCN(c3c(F)cc4c(=O)c(C(=O)[O-])cn(C5CC5)c4c3F)C2)nn1.[NH3+]CCO,,CCO,,,,val
US05733913,CN(C)C=O.ClCCl.Nc1ncc2cc(-c3ccccc3)c(O)nc2n1>>CCCCNc1nc2nc(N)ncc2cc1-c1ccccc1,,CN(C)C=O,,O=S(Cl)Cl,,val
US20160052897A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.FC(F)(F)c1cc(Br)c2c(c1)NCCO2>>CC(C)(C)OC(=O)N1CCOc2c(Br)cc(C(F)(F)F)cc21,CN(C)c1ccncc1,C1CCOC1,,,,val
US20070208024A1,COC(=O)c1ccc(-c2ccc(N(C)S(C)(=O)=O)cc2)cc1F>>CN(c1ccc(-c2ccc(C(=O)O)c(F)c2)cc1)S(C)(=O)=O,,C1CCOC1,CO,[Na+].[OH-],,val
US20050004149A1,CCCI.Nc1ncc(-c2ccc(=O)[nH]c2)c(-c2ccco2)n1>>CCCn1cc(-c2cnc(N)nc2-c2ccco2)ccc1=O,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150057264A1,CCOC(=O)c1cc(F)c[nH]1.O=C(CBr)c1ccc(Br)cc1>>CCOC(=O)c1cc(F)cn1CC(=O)c1ccc(Br)cc1,,CC(C)=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20050171130A1,CC(C)C(C)O.CCC#CCO.Clc1cc(Cl)ncn1>>CCC#CCOc1cc(OC(C)C(C)C)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20140018533A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)CC(=O)OCCO>>CCOC(=O)CC(=O)OCCOC(=O)OC(C)(C)C,CN(C)c1ccncc1,C1CCOC1,O,CCN(CC)CC,,val
US20100087427A1,CC(C)c1cccc(C[C@H]2CN(Cc3ccccc3)C[C@@H]2C#N)c1>>CC(C)c1cccc(C[C@H]2CNC[C@@H]2C#N)c1,,ClCCCl,,CC(Cl)OC(=O)Cl,,val
US20080176926A1,CCc1sc(C(=O)O)c2c1CC(C)(C)CC2.[Li]C>>CCc1sc(C(C)=O)c2c1CC(C)(C)CC2,,CCOCC,,,,val
US20100113503A1,CNC1CCC2(CC1)OCCO2.O=S(=O)(Cl)c1ccc(F)cc1>>CN(C1CCC2(CC1)OCCO2)S(=O)(=O)c1ccc(F)cc1,,ClCCl,,CCN(CC)CC,,val
US20110288090A1,CCOC(=O)C(c1ccncc1)c1nccc2nc(-c3ccc(CNC(=O)OC(C)(C)C)cc3)c(-c3ccccc3)cc12.Cl>>CCOC(=O)C(c1ccncc1)c1nccc2nc(-c3ccc(C[NH3+])cc3)c(-c3ccccc3)cc12.[Cl-],,CO,,,,val
US20080070935A1,CC1(C)CC(=O)c2c(C(F)(F)F)n[nH]c2C1.Nc1ncc(Br)c2cc(F)ccc12>>CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc4c(N)ncc(Br)c4c3)c2C1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20120040957A1,CC(C)(C)OC(=O)NC1CCN(CCO)CC1.COc1ccc2ncc(Cl)nc2c1>>COc1ccc2ncc(OCCN3CCC(NC(=O)OC(C)(C)C)CC3)nc2c1,,CN(C)C=O,,[H-].[Na+],,val
US20090239810A1,CCOC(=O)CC(=O)Nc1nc(-c2ccccc2)ns1>>O=C(O)CC(=O)Nc1nc(-c2ccccc2)ns1,,CO,O,[Li]O,,val
US20090291978A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1ccc(CO)cc1>>CC(C)(C)OC(=O)NCc1ccc(C(=O)O)cc1,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20060247260A1,CCCC[Sn](CCCC)(CCCC)c1ccc(OCc2ccccc2)nc1.COC(=O)c1ccc(Br)cc1>>COC(=O)c1ccc(-c2ccc(OCc3ccccc3)nc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20120101124A1,CCOC(=O)CCc1ccc(C#N)c2c1ccn2S(=O)(=O)c1ccc(C)cc1>>CCOC(=O)CCc1ccc(C#N)c2[nH]ccc12,,C1CCOC1,,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US05116984,Cc1c(C=O)ncn1C(c1ccccc1)(c1ccccc1)c1ccccc1.O=C1CCCc2ccc3ccccc3c21>>Cc1c(C=C2CCc3ccc4ccccc4c3C2=O)ncn1C(c1ccccc1)(c1ccccc1)c1ccccc1,,CO,,[K+].[OH-],,val
US04163104,COC(CN)OC.CSC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NN1C>>COC(CNC1=NN=Cc2ccccc2N1)OC,,CCOCCO,,,,val
US20140315888A1,C[C@H]1CNCCN1C(=O)OC(C)(C)C.Clc1cnc2nc(Cl)c(Cl)nc2c1>>C[C@H]1CN(c2nc3ncc(Cl)cc3nc2Cl)CCN1C(=O)OC(C)(C)C,,ClCCl,,[Cl-].[NH4+],,val
US20070093548A1,COc1ccc2c(oc3ccc(C#N)cc32)c1C1CCCC1>>N#Cc1ccc2oc3c(C4CCCC4)c(O)ccc3c2c1,,ClCCl,,BrB(Br)Br,O,val
US20040138254A1,CC(C)(C)OC(=O)N1C[C@@H]2CC[C@H](Oc3cc(-n4cccn4)ccc3-c3nn[nH]n3)C[C@H]2C[C@H]1C(=O)O.Cl>>Cl.O=C(O)[C@@H]1C[C@@H]2C[C@@H](Oc3cc(-n4cccn4)ccc3-c3nn[nH]n3)CC[C@H]2CN1,,CCOCC,ClCCl,,,val
US05936109,COC(=O)/C(=C/c1ccc2ccccc2c1)NC(C)=O>>COC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O,,CO,,,,val
US20090227789A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N[C@@H]1CCC(O)C[C@@H]1NC(=O)OC(C)(C)C>>CC(=O)OC1CCC(NC(=O)OC(C)(C)C)C(NC(=O)OC(C)(C)C)C1,,c1ccncc1,,CCOC(C)=O,Cl,val
US20110118257A1,C#CCO.Nc1ncnc2c1c(I)nn2Cc1oc2ccccc2c(=O)c1-c1ccccc1>>Nc1ncnc2c1c(C#CCO)nn2Cc1oc2ccccc2c(=O)c1-c1ccccc1,[Cu]I,C1CCOC1,,ClCCl,,val
US20070287725A1,O=C1CCC(=O)N1Cl.O=C1c2ccccc2C(=O)N1CC=NO>>O=C1c2ccccc2C(=O)N1CC(Cl)=NO,,CCOC(C)=O,CN(C)C=O,,,val
US20060173018A1,CCOCC.Cc1ccc2c(N3CCC[C@@H](CNC(=O)[O-])C3)nc(-c3c(O)cccc3F)nc2c1.Cl>>COCCN(C[C@H]1CCCN(c2nc(-c3c(O)cccc3F)nc3cc(C)ccc23)C1)C(=O)O.Cl,,ClCCl,,,,val
US04288434,CC(=O)OCC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)C(=NO)c3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)[C@H]2SC1.CC(C)(C)OC(=O)CBr>>CC(=O)OCC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)C(=NOCC(=O)OC(C)(C)C)c3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)[C@H]2SC1,O=[Ag],CN(C)C=O,,,,val
US20070054902A1,COCCl.OCc1cc(-c2ccc(C(F)(F)F)cc2)on1>>COCOCc1cc(-c2ccc(C(F)(F)F)cc2)on1,,C1CCOC1,,[H-].[Na+],,val
US20070270398A1,NC(=O)C1CCNCC1.O=C1CN(C(c2ccccc2)c2ccccc2)C1>>NC(=O)C1CCN(C2CN(C(c3ccccc3)c3ccccc3)C2)CC1,,CC(=O)O,,CO,,val
US20150376181A1,COc1ccc(CN2C(=O)c3nccc(OC)c3C23CCCCC3)cc1>>COc1ccc(CN2C(=O)c3nccc(O)c3C23CCCCC3)cc1,,ClCCl,,BrB(Br)Br,,val
US20140309178A1,CC(=O)OO.COC(=O)CCCc1ccc(Cc2cc([C@@H]3O[C@H](SC)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)ccc2C)cc1>>COC(=O)CCCc1ccc(Cc2cc([C@@H]3O[C@H]([S@](C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)ccc2C)cc1,,CC#N,CC(=O)O,,,val
US20110294781A1,Cc1ccc(-c2cc3nc(NN)cc(N4CCOCC4)n3n2)cn1.Cc1cccc(C=O)c1>>Cc1cccc(C=NNc2cc(N3CCOCC3)n3nc(-c4ccc(C)nc4)cc3n2)c1,,CCO,,CC(=O)O,,val
US20160151362A1,N#Cc1cccnc1Cl.NC(N)=S>>N#Cc1cccnc1S,,CCCCO,,,,val
US20100105659A1,CCOC(=O)N1C2CCC1CC(c1nsc(Nc3ncc(C(F)(F)F)cc3Oc3cccnc3C)n1)C2>>Cc1ncccc1Oc1cc(C(F)(F)F)cnc1Nc1nc(C2CC3CCC(C2)N3)ns1,O,CC(C)O,,[K+].[OH-],,val
US20080227774A1,CCOC(=O)CC(=O)C(C)(CCC(C)C)n1cccc1C(=O)OC>>CCOC(=O)C1=C(O)c2cccn2C(C)(CCC(C)C)C1=O,,CCO,,C,C[O-].[Na+],val
US08389731B2,C=CCO[C@@H](CNCc1ccccc1)[C@H](Cc1cc(C)cc(-n2c(C)ccc2C)n1)C(=O)OC(C)C>>C=CCO[C@@H](CNCc1ccccc1)[C@@H](CO)Cc1cc(C)cc(-n2c(C)ccc2C)n1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04255587,CCOC(=O)C(C)Br.Cc1cccc(C)c1N>>CCOC(=O)C(C)Nc1c(C)cccc1C,,c1ccccc1,,,,val
US04224344,O=CC12CC(c3ccccc31)c1ccccc12>>OCC12CC(c3ccccc31)c1ccccc12,,CO,O,[BH4-].[Na+],,val
US20160052939A1,CC(C)(C)OC(=O)N1C[C@H]2C[C@@H](Nc3ccc(Cl)cn3)[C@@H]1C2>>Clc1ccc(N[C@@H]2C[C@@H]3CN[C@H]2C3)nc1,,C1COCCO1,CCOC(C)=O,Cl,,val
US20050054590A1,Brc1ccccc1.Nc1ncccn1>>Nc1nccc(-c2ccccc2)n1,,C1CCOC1,Cc1ccccc1,[Li]CCCC,,val
US20100173933A1,Cc1nc2ccc(Oc3ccccc3)cc2s1.O=C1CCC(=O)N1Br>>BrCc1nc2ccc(Oc3ccccc3)cc2s1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20080085890A1,COC(OC)OC.COc1ccc2c(c1)CC(=O)NC2=O>>COC=C1C(=O)NC(=O)c2ccc(OC)cc21,,CN(C)C=O,,CC(=O)OC(C)=O,,val
US20140350019A1,Cc1c(O)ccc(F)c1NC(=O)c1cc(-c2cccc(F)c2)ccc1F>>Cc1c(O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F,,C1CCOC1,,,,val
US20060281695A1,BrCc1ccccc1.O=S(=O)(Nc1ccc(Cl)cc1Oc1ccc(Cl)cc1Cl)C(F)(F)F>>O=S(=O)(N(Cc1ccccc1)c1ccc(Cl)cc1Oc1ccc(Cl)cc1Cl)C(F)(F)F,,CC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20100286110A1,CCOC(=O)CBr.CS(=O)(=O)c1ccc(-c2ccc(OC3CNC3)cc2)cn1>>CS(=O)(=O)c1ccc(-c2ccc(OC3CN(CC(=O)O)C3)cc2)cn1,,CN(C)C=O,,CCN(CC)CC,,val
US04792607,Nc1nc2ccccc2s1.[N-]=C=O>>NC(=O)C1N=CC=CN1,,ClC(Cl)Cl,,,,val
US20080009530A1,CCOC(=O)/C=C/c1ccc(OCCO[Si](C(C)C)(C(C)C)C(C)C)cc1Oc1ncc(C(F)(F)F)cc1Cl>>CC(C)[Si](OCCOc1ccc(/C=C/C(=O)O)c(Oc2ncc(C(F)(F)F)cc2Cl)c1)(C(C)C)C(C)C,,CCO,,C1CCOC1,[Na+].[OH-],val
US20140315889A1,C=C1CCc2c(c3cc(F)ccc3n2Cc2ccc(C(=O)OC)cc2)C1=O.CN1CCNCC1>>COC(=O)c1ccc(Cn2c3c(c4cc(F)ccc42)C(=O)C(CN2CCN(C)CC2)CC3)cc1,,Cc1ccccc1,,,,val
US20040164272A1,C=CC(=O)OCCCCO.Cc1cc(N=Nc2ccc(N=Nc3ccccc3)cc2)ccc1O>>C=CC(=O)OCCCCOc1ccc(N=Nc2ccc(N=Nc3ccccc3)cc2)cc1C,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04871721,CCOP([O-])OCC.FC(F)Cl>>CCOP(=O)(OCC)C(F)F,,C1CCOC1,CCCCCC,[H-].[Na+],,val
US20140135499A1,C[Si](C)(C)C#CC(=O)c1ccccc1[N+](=O)[O-]>>C[Si](C)(C)CCC(=O)c1ccccc1N,[Pd],CCOC(C)=O,Cc1ccccc1,Cl,,val
US05225423,CNC.CSC(=CC(=O)C(F)(F)F)NCc1ccc(Cl)nc1>>CN(C)C(=CC(=O)C(F)(F)F)NCc1ccc(Cl)nc1,,CCO,,,,val
US20120283273A1,CCN(CC)S(F)(F)F.Cc1c(Cl)ncnc1C(C)O>>Cc1c(Cl)ncnc1C(C)F,,ClCCl,,,,val
US20110098296A1,COC(=O)c1cccc(C(=O)Nc2c(F)cccc2F)c1.Cc1ccnc(Cl)n1>>O=C(Cc1ccnc(Cl)n1)c1cccc(C(=O)Nc2c(F)cccc2F)c1,,C1CCOC1,,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20050054701A1,CC(C)=NO.COC(=O)c1cc(C(C)=O)c(F)c(F)c1Nc1ccccc1Cl>>COC(=O)c1cc(C(C)=O)c(ON=C(C)C)c(F)c1Nc1ccccc1Cl,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20020032227A1,CON=C(c1noc(C)n1)c1cc(Cl)ccc1O.FC(F)(F)c1ccc(Cl)nc1>>CON=C(c1noc(C)n1)c1cc(Cl)ccc1Oc1ccc(C(F)(F)F)cn1,,CCOCC,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150191434A1,CCOC(=O)C1(C)CCC(=O)CC1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)C1(C)CC=C(OS(=O)(=O)C(F)(F)F)CC1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20150344459A1,CCC(C)n1cc(C)c2c(C(=O)OC)cc(-c3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)nc3)cc21>>CCC(C)n1cc(C)c2c(C(=O)O)cc(-c3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)nc3)cc21,,CCO,,[Na+].[OH-],,val
US05112988,C=COC(=O)N1CC2C(=O)C=CC(c3ccccc3)(c3ccccc3)C2C1.Cl>>Cl.O=C1C=CC(c2ccccc2)(c2ccccc2)C2CNCC12,,C1COCCO1,,,,val
US20070299258A1,CC(=O)O[C@@H](C)C(=O)N1CCC(CCn2c(Sc3nc4cccc(Cl)c4s3)nc3c(N)ncnc32)CC1>>C[C@H](O)C(=O)N1CCC(CCn2c(Sc3nc4cccc(Cl)c4s3)nc3c(N)ncnc32)CC1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20160159774A1,Nc1ccc(F)cc1.O=[N+]([O-])c1ccc(CBr)c(CBr)c1>>O=[N+]([O-])c1ccc2c(c1)CN(c1ccc(F)cc1)C2,,Cc1ccccc1,O,CCN(C(C)C)C(C)C,,val
US20040138211A1,COC(=O)CC(=O)OC.O=Cc1ccc(OCCOc2ccc3c(c2)CCCC3)cc1>>COC(=O)C(=Cc1ccc(OCCOc2ccc3c(c2)CCCC3)cc1)C(=O)OC,,Cc1ccccc1,,C1CC[NH2+]CC1.CC(=O)[O-],,val
US03959260,BrBr.CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](C)C[C@]4(C)[C@H]3C(=O)C[C@]12C>>C[C@@H]1C[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CBr)[C@@]4(C)CC(=O)[C@@H]32)C[C@@H]1O,,CO,,,,val
US20150282482A1,CSSC.Fc1ccc(Br)cc1C1OCCO1>>Cc1ccc(F)c(C=S)c1,,C1CCOC1,,Cl,[Li]CCCC,val
US04883914,CN=C=O.Cc1ccc(S(=O)(=O)NC(=O)C(C)(N)C(C)C)cc1>>CNC(=O)NC(C)(C(=O)NS(=O)(=O)c1ccc(C)cc1)C(C)C,,C1CCOC1,CN(C)C=O,Cl,,val
US20100322855A1,CC(C)(C)OC(=O)CN(CCO)Cc1ccccc1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)CN(CCBr)Cc1ccccc1,,CCOCC,ClCCl,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04270948,CC(Oc1ccc(O)cc1)C(N)=O.FC(F)(F)c1ccc(Cl)cc1>>CC(Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)C(N)=O,,CS(C)=O,,[K+].[OH-],,val
US09296736B2,C=CC[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N([C@H](CC)CO)C1=O.CI>>C=CC[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N([C@@H](CC)COC)C1=O,,C1CCOC1,,[H-].[Na+],,val
US20090306139A1,CCOC(=O)C1CC(c2ccc(CC)cc2)CN(C(=O)N2CCC(C#N)CC2)C1>>CCc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCC(C#N)CC3)C2)cc1,,C1COCCO1,O,[Li+].[OH-],,val
US20080269220A1,CC(C)(C)c1cc(CCc2ccccc2)[nH]n1.COC(=O)c1ccc(CBr)cc1>>COC(=O)c1ccc(Cn2nc(C(C)(C)C)cc2CCc2ccccc2)cc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20130029969A1,C=O.O=c1[nH]c(CNCc2ccccc2)nc2cc(Br)sc12>>O=c1c2sc(Br)cc2nc2n1CN(Cc1ccccc1)C2,,C1CCOC1,,,,val
US20150105393A1,C1CCOC1.C[O-].O=C(OCC(F)(F)F)c1ccc(OCC(F)(F)F)nc1Cl>>COC(=O)c1ccc(OCC(F)(F)F)nc1OC,,C1CCOC1,,[Cl-].[NH4+],,val
US20060105987A1,CC(O)=S.CCCCCCCCCCCCCCBr>>CCCCCCCCCCCCCCCC(O)=S,,CO,O,Cl,C[O-].[Na+],val
US20090105072A1,Cc1ccc(C#N)nc1Br.[Cl-].[NH4+]>>Cc1ccc(C(=N)N)nc1Br.Cl,,CO,,C[O-].[Na+],,val
US05714714,CCOC(=O)N[N+](=O)[O-].N>>CCOC(=O)N[N+](=O)[O-].[NH4+],,CO,,ClCCl,,val
US05306692,CCOC(=O)C(C)n1ncc2ccc(Oc3c(F)cc(C(F)(F)F)cc3Cl)cc21.N>>CC(C(N)=O)n1ncc2ccc(Oc3c(F)cc(C(F)(F)F)cc3Cl)cc21,,CO,,,,val
US20040014776A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NS(=O)(=O)c1ccc(I)cc1>>CC(C)(C)OC(=O)NS(=O)(=O)c1ccc(I)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20090275523A1,COC(=O)[C@@H](N)CC(F)(F)Cc1ccccc1.O=C(Cl)Cl>>COC(=O)[C@H](CC(F)(F)Cc1ccccc1)N=C=O,,Cc1ccccc1,ClCCl,c1ccncc1,,val
US20150210682A1,CCOC=O.COc1ccc(CC(C)N)cc1>>COc1ccc(CC(C)NC=O)cc1,,C1COCCO1,,,,val
US20080039444A1,COC(=O)c1ccncc1C(=O)Cc1ccc(Cl)cc1.NN>>O=c1[nH]nc(Cc2ccc(Cl)cc2)c2cnccc12,CC(=O)O,CCO,,O,,val
US20030050288A1,Fc1ccc(Br)cc1Cl.O=C1Nc2ccccc2C12CCCC2B(O)O>>O=C1Nc2ccc(-c3ccc(F)c(Cl)c3)cc2C12CCCC2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,[Na+].[OH-],,val
US20090005379A1,CC(C)(C)OC(=O)n1c(C(=O)N2CCC(F)(F)CC2)cc2cc(OCCCCl)cnc21>>O=C(c1cc2cc(OCCCCl)cnc2[nH]1)N1CCC(F)(F)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160060258A1,CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3ncc4c(=O)n(-c5c(Cl)cccc5Cl)cc(-c5cccnc5)c4n3)cc2)CC1>>O=c1c2cnc(Nc3ccc(N4CCNCC4)cc3)nc2c(-c2cccnc2)cn1-c1c(Cl)cccc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US05399574,N#CCCC=NNc1ccc(C[C@H]2COC(=O)N2)cc1>>N#CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12,,ClC(Cl)Cl,,,,val
US20040067935A1,CN(Cc1ccccc1)[C@@H]1CCN(CCc2ccc(F)cc2)C[C@H]1CN=[N+]=[N-]>>CN(Cc1ccccc1)[C@@H]1CCN(CCc2ccc(F)cc2)C[C@H]1CN,[Pd],CCO,,,,val
US04666916,CI.COc1cc(Br)c2c(c1)[C@H]1CN(C)CC[C@H]1CO2>>COc1cc(C)c2c(c1)[C@H]1CN(C)CC[C@H]1CO2,,C1CCOC1,CCOC(C)=O,O,[Li]CCCC,val
US05461158,C/C=C(\CBr)C(=O)OC.CC(C)(C=O)SCc1ccccc1>>C=C1C(=O)OC(C(C)(C)SCc2ccccc2)C1C,[Zn],C1CCOC1,,Cl,[Cl-].[NH4+],val
US20040006141A1,CCCC(Cc1ccc(OCc2ccccc2)cc1)C(=O)OCC>>CCCC(Cc1ccc(O)cc1)C(=O)OCC,[Pd],,,,,val
US20120277207A1,CCOC(=O)/C=C/c1cnc2c(c1)CC1(CCN(C)CC1)C(=O)N2.ClCCl>>Cl.O=C(O)/C=C/c1cnc2c(c1)CCC(=O)N2,,CCO,,[Na+].[OH-],,val
US20080287410A1,CC(C)(C)OC(=O)NC1CCC(CNc2nc(Cl)ncc2[N+](=O)[O-])CC1.NCc1cnccc1Cl>>N[C@@H]1CC[C@@H](CNc2nc(NCc3cnccc3Cl)ncc2[N+](=O)[O-])CC1,,ClCCl,,,,val
US20090270363A1,CO.O=[N+]([O-])c1cc(N2CCCC2)ccc1-c1nc2c(s1)C(O)CCC2>>COC1CCCc2nc(-c3ccc(N4CCCC4)cc3N)sc21,[Fe],CC(=O)O,,,,val
US20160244438A1,CC(C)(C)OC(=O)N1CCOC[C@H]1CO>>CC(C)(C)OC(=O)N1CCOC[C@H]1C=O,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20050070574A1,CCC(=O)c1ccccc1.O=C1Nc2cc(Cl)ccc2C1=O>>Cc1c(-c2ccccc2)nc2cc(Cl)ccc2c1C(=O)O,,CCO,,[K+].[OH-],,val
US20050070549A1,CC(C)(O)c1ccc2c(c1)C(=CCCNCCNc1ccc(Cl)cc1)c1cccnc1CO2.CC(Cl)Cl.CC=O>>CCN(CCC=C1c2cc(C(C)(C)O)ccc2OCc2ncccc21)CCN(CC)c1ccc(Cl)cc1,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20160000760A1,CC(C)(C)OC(=O)N1CC(S(=O)(=O)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)C1.Nc1nc(Nc2cc(Cl)c(Br)c(C(F)(F)F)c2)n[nH]1>>CC(C)(C)OC(=O)N1CC(S(=O)(=O)c2ccc(-c3c(Cl)cc(Nc4n[nH]c(N)n4)cc3C(F)(F)F)cc2)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,COCCOC,O=C([O-])[O-].[K+].[K+],val
US04115382,CN(C)CCCOc1ccccc1N.O=Cc1cccc(C(F)(F)F)c1>>CN(C)CCCOc1ccccc1N=Cc1cccc(C(F)(F)F)c1,,Cc1ccccc1C,,O,,val
US20120083475A1,CC1(C)OC(=O)C2(CC2)C(=O)O1.N#Cc1ccc(N)cc1>>N#Cc1ccc(N2CCC(C(=O)O)C2=O)cc1,,CCO,,,,val
US20060217372A1,N#Cc1ccc(Oc2ccc(C=O)cn2)c(Br)c1.OO>>NC(=O)c1ccc(Oc2ccc(C=O)cn2)c(Br)c1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20050054863A1,CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C.ClCCl>>O=C(Cl)c1ccccc1,,CCOC(C)=O,,CC(=O)O,,val
US20150283117A1,COC(=O)c1ccc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)cc1OC.C[Al](C)C.Cc1cc(N)c(N)c(C)c1C>>COc1cc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)ccc1-c1nc2cc(C)c(C)cc2n1C,,Cc1ccccc1,,,,val
US04416985,CC(C)(C)[Si](C)(C)O[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)C(=O)[C@H]5C[C@H]5[C@H]4[C@@H]3[C@H](Cl)[C@H]3O[C@]32C1.CCOCC.CO.O=S(=O)(O)O>>CC(C)OC(C)C.C[C@]12CC[C@H]3[C@@H]([C@H](Cl)[C@H]4O[C@]45C[C@@H](O)CC[C@]35C)[C@@H]1[C@@H]1C[C@@H]1C2=O,,C1CCOC1,CCOCC,,,val
US04355164,CC(C)CCON=O.COC(=O)CC(=O)c1sc2nc(C)ccc2c1N>>COC(=O)c1nnc2c(sc3nc(C)ccc32)c1O,,C1COCCO1,CC(=O)O,,,val
US20100324041A1,Clc1c(Br)cnc2[nH]ccc12.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(c1ccccc1)n1ccc2c(Cl)c(Br)cnc21,,CN(C)C=O,,O,[H-].[Na+],val
US20150274704A1,CC(C)(C)OC(=O)N1CCC2(CCC(Nc3ccnc(Cl)n3)CC2)C1.Cn1cc(N)cn1>>Cn1cc(Nc2nccc(NC3CCC4(CC3)CCN(C(=O)OC(C)(C)C)C4)n2)cn1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US05130309,CCN1CC(Oc2ccc([N+](=O)[O-])cc2)C1>>CCN1CC(Oc2ccc(N)cc2)C1,[Pd],CCO,,,,val
US20040010007A1,Cc1nc(Cl)c([N+](=O)[O-])c(NCCOCCCc2cccnc2)c1C.Oc1ccccc1>>Cc1nc(Oc2ccccc2)c([N+](=O)[O-])c(NCCOCCCc2cccnc2)c1C,,COCCOCCOC,,[H-].[Na+],,val
US04959364,C1COCCN1.C=CC(=O)Cl>>C=CC(=O)N1CCOCC1,,CCOCC,,CCN(CC)CC,,val
US20070203194A1,CCO.Nc1ccc(F)cc1.O=C([O-])CBr>>CCOC(=O)CNc1ccc(F)cc1,,CCO,,CC(=O)[O-].[Na+],,val
US03954789,Cn1c(C=O)cnc1[N+](=O)[O-]>>Cn1c(CO)cnc1[N+](=O)[O-],,CCO,,Cl,[BH4-].[Na+],val
US20040157886A1,Nc1cccc(O)c1.O=C(O)C(=O)N1CCC(Cc2ccccc2)CC1>>O=C(Nc1cccc(O)c1)C(=O)N1CCC(Cc2ccccc2)CC1,,O,,,,val
US20070244159A1,COC(=O)C1(c2ccc3[nH]ccc3c2)CC1>>O=C(O)C1(c2ccc3[nH]ccc3c2)CC1,,CO,O,Cl,[Li+].[OH-],val
US20150183797A1,CC1(C)C=Cc2cc(Br)ccc2O1.COc1ccc(C=O)cc1OC>>COc1ccc(C(O)c2ccc3c(c2)C=CC(C)(C)O3)cc1OC,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20150232428A1,Cc1cc(-c2ccccc2)cc([N+](=O)[O-])c1>>Cc1cc(N)cc(-c2ccccc2)c1,[Pd],CC(=O)O,CCOC(C)=O,ClCCl,,val
US20060041123A1,CC(C)(C)OC(=O)N1CCC(CO)(NC(=O)c2ccc3c(n2)NC(=O)CS3)CC1>>O=C1CSc2ccc(C(=O)NC3(CO)CCNCC3)nc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060223801A1,COC(=O)C1(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)C=CN=C(Cl)N1.NCCN1CCOCC1>>Cc1[nH]c(C(=O)NC2CCN(c3cc(C(=O)NCCN4CCOCC4)nc(Cl)n3)CC2)c(Cl)c1Cl,,CCOC(C)=O,O,CN(C)C=O,,val
US05204473,CCCCN.CON1C(C)(C)CC(=O)CC1(C)C>>CCCCNC1CC(C)(C)N(OC)C(C)(C)C1,[Pt],CO,,,,val
US20140051679A1,BrC1CC1.N#Cc1ccccc1F>>NC(c1ccccc1F)C1CC1,,CO,,C1CCOC1,[BH4-].[Na+],val
US20070219235A1,CC(C)(C)OC(=O)N1CCN(c2cc3[nH]c(Nc4ccccc4C(F)(F)F)nc3cc2C(=O)Nc2ccc3cn[nH]c3c2)CC1>>O=C(Nc1ccc2cn[nH]c2c1)c1cc2nc(Nc3ccccc3C(F)(F)F)[nH]c2cc1N1CCNCC1,,C1COCCO1,,Cl,,val
US20110112151A1,Cc1nnc(S)n1C.O=C(CBr)C12CC3CC(CC(C3)C1)C2>>Cc1nnc(SCC(=O)C23CC4CC(CC(C4)C2)C3)n1C,,CC#N,,CCN(CC)CC,,val
US20050171110A1,C[Si](C)(C)CCOCn1nc2c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)c(=O)[nH]n2c1=O.FC(F)(F)c1ccc(CBr)cc1>>C[Si](C)(C)CCOCn1nc2c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)c(=O)n(Cc3ccc(C(F)(F)F)cc3)n2c1=O,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20070015802A1,COC(=O)c1ccccc1OC.COc1cc(OC)c([C@@H]2CCN(C)[C@H]2CO)c(O)c1C(C)=O>>COc1ccccc1-c1cc(=O)c2c(OC)cc(OC)c([C@@H]3CCN(C)[C@H]3CO)c2o1,,CN(C)C=O,,[H-].[Na+],,val
US20120165298A1,O=Cc1ccccc1-c1ccc(Cl)cc1.O=S(=O)(Nc1nnc2n1CCN(C1CCCNCC1)C2)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(S(=O)(=O)C(F)(F)F)c1>>O=S(=O)(Nc1nnc2n1CCN(C1CCCN(Cc3ccccc3-c3ccc(Cl)cc3)CC1)C2)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(S(=O)(=O)C(F)(F)F)c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US04880838,Cc1cc(N)c(C)c(Cl)c1Oc1ccc(Cl)cc1Cl.O=C=NC(=O)c1c(F)cccc1F>>Cc1cc(NC(=O)NC(=O)c2c(F)cccc2F)c(C)c(Cl)c1Oc1ccc(Cl)cc1Cl,,Cc1ccccc1,,CCCCCC,,val
US20100069381A1,CS(=O)(=O)Cl.Cc1nnc(-c2ccc3ncn(C4CCNCC4)c3c2)o1>>Cc1nnc(-c2ccc3ncn(C4CCN(S(C)(=O)=O)CC4)c3c2)o1,,C1CCOC1,,CCN(CC)CC,,val
US06936602B1,CCC(=O)Cl.CCCOCCOc1ccc2c(c1)C=C(C(=O)OC)CCN2>>CCCOCCOc1ccc2c(c1)C=C(C(=O)OC)CCN2C(=O)CC,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130082209A1,CC(C)(C)c1ccc(C#N)c(Cl)n1.Nc1ccccc1N>>CC(C)(C)c1ccc(-c2nc3ccccc3[nH]2)c(Cl)n1,,CCO,Cl,Cc1ccc(S(=O)(=O)O)cc1,O,val
US05281603,CCCCc1nc(=O)c2cc(I)ccc2[nH]1.N#C[Cu]>>CCCCc1nc(=O)c2cc(C#N)ccc2[nH]1,,c1ccncc1,,O,,val
US20040077584A1,CCN.CCOC(=O)c1nc(NCC(c2ccccc2)c2ccccc2)c2ncn([C@@H]3O[C@H](C(=O)O)[C@H]4OC(C)(C)O[C@H]43)c2n1>>CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(C(=O)OCC)nc32)[C@@H]2OC(C)(C)O[C@@H]21,,C1CCOC1,,O,O=C(n1ccnc1)n1ccnc1,val
US20110152282A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.Cc1ccc(N2C(=O)c3ccccc3C2=O)nc1Br>>Cc1ccc(N2C(=O)c3ccccc3C2=O)nc1-c1ccccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,Cc1ccccc1,,val
US20060094743A1,CN(C)C=O.Cc1ccc(CC#N)c(C(=O)O)c1>>Cc1ccc(CC#N)c(C(N)=O)c1,,C1CCOC1,,O=C(Cl)C(=O)Cl,,val
US20090105306A1,CC(C)(C)c1nn(C[C@H]2CCCO2)c(=N)s1.CC1CCC(N)CC1.O=C(Cl)Nc1ccc([N+](=O)[O-])cc1>>CC1CCC(NC(=O)/N=c2\sc(C(C)(C)C)nn2C[C@H]2CCCO2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US05034417,CC1(c2ccc([N+](=O)[O-])c(Cl)c2)OCCO1.Nc1ccc(Cl)cc1Cl>>CC1(c2ccc([N+](=O)[O-])c(Nc3ccc(Cl)cc3Cl)c2)OCCO1,,CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120309755A1,CNc1nc(OCC(F)F)c(C(=O)O)cc1[N+](=O)[O-].FC(F)(F)C1CCNCC1>>CNc1nc(N2CCC(C(F)(F)F)CC2)c(C(=O)O)cc1[N+](=O)[O-],,CC#N,O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20090118263A1,COc1nc2c(N)nc(NCc3ccncc3)nc2n1Cc1ccc(CO)cc1.O=S(Cl)Cl>>Nc1nc(NCc2ccncc2)nc2c1[nH]c(=O)n2Cc1ccc(CCl)cc1,,ClC(Cl)Cl,,,,val
US20150094339A1,CC(=O)OCBr.COc1ccnc(C(=O)N[C@H]2COC[C@H](Cc3cccc4ccccc34)[C@@H](OC(=O)C(C)C)[C@H](C)OC2=O)c1O>>COc1ccnc(C(=O)N[C@H]2COC[C@H](Cc3cccc4ccccc34)[C@@H](OC(=O)C(C)C)[C@H](C)OC2=O)c1OCOC(C)=O,,CC(C)=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US05134142,CCOC(=O)c1cc(-c2ccc(S(C)(=O)=O)cc2)n(-c2ccc(OC)cc2)n1>>CS(=O)(=O)c1ccc(-c2cc(C(=O)O)nn2-c2ccc(O)cc2)cc1,,CC(=O)O,,I,,val
US04082781,CCCCCCCCCCCCCCCC(=O)Nc1cc([N+](=O)[O-])ccc1O.O=P(Cl)(Cl)CCBr>>CCCCCCCCCCCCCCCC(=O)NC1C=C([N+](=O)[O-])C=CC1=[P+]([O-])CCBr,,c1ccccc1,,O,[Na],val
US05858995,Cc1oc2c(NC(=O)c3c(Cl)cccc3Cl)ccc(CO)c2c1C1CCCCC1>>Cc1oc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1CC1CCCCC1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20100256156A1,CCOC(=O)CCN(C)C(=O)c1ccc(NC(CC(C)C)c2cc(-c3ccc(OC)nc3)oc2C)cn1>>COc1ccc(-c2cc(C(CC(C)C)Nc3ccc(C(=O)N(C)CCC(=O)O)nc3)c(C)o2)cn1,,CCO,,C1CCOC1,[Li+].[OH-],val
US20010056100A1,COC(=O)[C@@H](Cc1ccccc1)N=C=O.OCc1ccc(COc2ccccc2)cc1>>COC(=O)[C@@H](Cc1ccccc1)NC(=O)OCc1ccc(COc2ccccc2)cc1,CN(C)c1ccncc1,,,,,val
US20030153604A1,CC(C)(C)OC(=O)NCC(C)(C)c1ccc(C(=O)NCCc2ccc3[nH]cc(C#N)c3c2)cc1>>CC(C)(CN)c1ccc(C(=O)NCCc2ccc3[nH]cc(C#N)c3c2)cc1,,ClCCl,,O,O=C(O)C(F)(F)F,val
US20050272753A1,CCOC(=O)C1COCCN1.O=[N+]([O-])c1ccc(F)cc1>>CCOC(=O)C1COCCN1c1ccc(N)cc1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20030153556A1,CCc1cc2c(N3CCN(C(=O)OC(C)(C)C)CC3)nc(C(=O)O)nc2s1.N>>CCc1cc2c(N3CCN(C(=O)OC(C)(C)C)CC3)nc(C(N)=O)nc2s1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US05846990,COCCOCN(c1noc(C)c1C)S(=O)(=O)c1ccccc1-c1ccc(-c2ncco2)cc1C=O>>COCCOCN(c1noc(C)c1C)S(=O)(=O)c1ccccc1-c1ccc(-c2ncco2)cc1CO,,CO,,[BH4-].[Na+],,val
US20080004275A1,Cc1cc(Cl)ccc1NC(=O)Nc1cn(CC2CC2)c(C(=O)O)n1.NCCCN1CCOCC1>>Cc1cc(Cl)ccc1NC(=O)Nc1cn(CC2CC2)c(C(=O)NCCCN2CCOCC2)n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080269220A1,COC(=O)c1ccc(CBr)c(OC(C)C)c1.OC1CCNCC1>>COC(=O)c1ccc(CN2CCC(O)CC2)c(OC(C)C)c1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20040209892A1,CN.Clc1cc(Oc2ccc(OCc3ccccc3)cc2)ccn1>>CNc1cc(Oc2ccc(OCc3ccccc3)cc2)ccn1,,C1CCOC1,,CCN(C(C)C)C(C)C,CS(C)=O,val
US06444826B1,OCC(Cc1ccccc1)C(O)c1ccc(Br)cc1F>>O[C@H]1c2ccc(Br)cc2OC[C@@H]1Cc1ccccc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20020143020A1,BrCC1CC1.OCc1c(F)cc(O)cc1F>>OCc1c(F)cc(OCC2CC2)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US06281355B1,CCCCCCN(CCNCCCC(=O)OC(C)(C)C)C(=O)C1Sc2ccccc2-c2[nH]c3ccccc3c21>>CCCCCCN(CCNCCC)C(=O)C1Sc2ccccc2-c2[nH]c3ccccc3c21,,O=CO,,,,val
US07678801B2,CCN(CC)CCCN.Cc1ccc(C(=O)O)cc1-c1nc(S(C)=O)nc2c1ccc(=O)n2-c1c(F)cccc1F>>CCN(CC)CCCNc1nc(-c2cc(C(=O)O)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1,,ClCCl,,,,val
US20110105502A1,CCCS(=O)(=O)Cl.NCCOc1ccc2c(c1)CCN=C2C1(c2ccc(Cl)cc2)CCC1>>CCCS(=O)(=O)NCCOc1ccc2c(c1)CCN=C2C1(c2ccc(Cl)cc2)CCC1,CN(C)c1ccncc1,ClCCl,,O,,val
US06300514B1,CC(C)(C)OC(=O)CCSc1ccc(N)cc1.O=C(Cl)c1ccccc1>>CC(C)(C)OC(=O)CCSc1ccc(NC(=O)c2ccccc2)cc1,,CCN(CC)CC,,Cl,,val
US20160000929A1,C#CCC(CC#C)COC(=O)c1ccc(OC(C)=O)cc1>>C#CCC(CC#C)COC(=O)c1ccc(O)cc1,,CO,,CCOC(C)=O,O,val
US05773459,O=C(Nc1ccc(Cl)nc1)OCc1ccccc1.Oc1ccc(Cl)cc1Cl>>Nc1ccc(Oc2ccc(Cl)cc2Cl)nc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150191432A1,CCOC(=O)CBr.CI.O=C1COc2cccc(O)c2N1>>CCOC(=O)COc1cccc2c1N(C)C(=O)CO2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120208815A1,CC1(C(=O)O)CCCNC1.O=[N+]([O-])c1cnccc1Cl>>CC1(C(=O)O)CCCN(c2ccncc2[N+](=O)[O-])C1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20090076046A1,CC(=O)c1ccc(NCc2ccc(C(F)(F)F)cc2)nc1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(=O)c1ccc(N(Cc2ccc(C(F)(F)F)cc2)C(=O)OC(C)(C)C)nc1,CN(C)c1ccncc1,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20050277678A1,CSc1ccc(-c2c(-c3ccccc3)noc2O)cc1.O=P(Cl)(Cl)Cl>>CSc1ccc(-c2c(-c3ccccc3)noc2Cl)cc1,,CCN(CC)CC,,,,val
US20150353553A1,COC(=O)c1nc(N[C@H](C)C2CC2)c2c(n1)nc(-c1cc(C)ccc1OCCC(=O)NCCO)n2Cc1ccc(Cl)cc1>>Cc1ccc(OCCC(=O)NCCO)c(-c2nc3nc(C(=O)O)nc(N[C@H](C)C4CC4)c3n2Cc2ccc(Cl)cc2)c1,,C1CCOC1,,[Li+].[OH-],,val
US20110319394A1,Cn1c(Cl)nc2ccccc21.Oc1ccc(Br)cc1>>Cn1c(Oc2ccc(Br)cc2)nc2ccccc21,,CCN(CC)CC,,,,val
US20110224225A1,CC(=O)OC(C)=O.COC(=O)[C@@H]1CC[C@H](N)C1>>COC(=O)[C@@H]1CC[C@H](NC(C)=O)C1,,c1ccncc1,,,,val
US20090298807A1,CCOC(CBr)OCC.OCCc1cccc(O)c1>>CCOC(COc1cccc(CCO)c1)OCC,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110060009A1,CCN(CC)S(F)(F)F.Cc1nn(C)c(C)c1C[C@H]1C[C@H](O)CN1C(=O)OCc1ccccc1>>Cc1nn(C)c(C)c1C[C@H]1C[C@@H](F)CN1C(=O)OCc1ccccc1,,ClCCl,ClCCl,,,val
US06689806B1,Cc1[nH]c(C=O)c(C)c1CCCN(C)C.O=C1Cc2ccc(-c3cccs3)cc2N1>>Cc1[nH]c(C=C2C(=O)Nc3cc(-c4cccs4)ccc32)c(C)c1CCCN(C)C,C1CCNCC1,CCO,,,,val
US20030225288A1,C1CCNCC1.O=Cc1ccc(Cl)c([N+](=O)[O-])c1>>O=[N+]([O-])c1cc(CN2CCCCC2)ccc1Cl,,C1CCOC1,CC(=O)O,[Na+].[OH-],,val
US03947584,CCC(C)(Cc1c[nH]c2ccccc12)[N+](=O)[O-]>>CCC(C)(N)Cc1c[nH]c2ccccc12,[Pd],CCO,,[H][H],,val
US04017503,CCCCOCCOCCOC(=O)Cl.c1ccc2[nH]c(-c3cscn3)nc2c1>>CCCCOCCOCCOC(=O)n1c(-c2cscn2)nc2ccccc21,,c1ccncc1,,,,val
US20130123500A1,Cn1nccc1C(=O)O.NNC(=O)c1ccc(C(F)(F)F)cc1>>Cn1nccc1C(=O)NNC(=O)c1ccc(C(F)(F)F)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040087600A1,CI.Nc1ccc2c(c1)NC(=O)CS2>>CN1C(=O)CSc2ccc(N)cc21,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20120136151A1,CC(C)(Cc1ccccc1)OC(=O)C[C@H]1C[C@@H](CS(=O)(=O)c2nnnn2-c2ccccc2)OC(C)(C)O1.CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1C=O>>CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1/C=C/[C@@H]1C[C@H](CC(=O)OC(C)(C)Cc2ccccc2)OC(C)(C)O1,,C1CCOC1,CCOC(C)=O,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20030018024A1,COc1ccccc1-c1ccc(C(=O)O)cc1.c1ccc2c(c1)Cn1cccc1CN2>>COc1ccccc1-c1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1,,ClCCl,O=S(Cl)Cl,CCN(C(C)C)C(C)C,,val
US20090208485A1,Cc1cc(C(F)(F)F)cc(N2CCN(C(=O)[C@@]3(C(C)C)CC[C@@H](NC(=O)OC(C)(C)C)C3)CC2)n1>>Cc1cc(C(F)(F)F)cc(N2CCN(C(=O)[C@@]3(C(C)C)CC[C@@H](N)C3)CC2)n1,,Cl,ClCCl,C1COCCO1,,val
US20150031708A1,COc1ccc(B2OC(C)(C)C(C)(C)O2)c(C)n1.Cc1cc(Cl)nc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)c1>>COc1ccc(-c2cc(C)cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)n2)c(C)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20150087646A1,CC(C)c1nnc(-c2ccc(C(N)=O)cc2)o1.O=C(Cl)C(=O)Cl>>CC(C)c1nnc(-c2ccc(C(=O)N=C=O)cc2)o1,,ClCCCl,,,,val
US20110263559A1,O=c1[nH]n(-c2ccccc2)c2cc([N+](=O)[O-])ccc12.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>O=[N+]([O-])c1ccc2c(=S)[nH]n(-c3ccccc3)c2c1,,CCOC(C)=O,,Cc1ccccc1C,,val
US05256824,CC(C)(C)NC1CCC(c2ccccc2)(c2ccccc2)C1.CS(=O)(=O)O>>CC(C)(C)NC1CCC(c2ccccc2)(c2ccccc2)C1.CS(=O)(=O)O,,CO,ClC(Cl)Cl,,,val
US20040224960A1,CI.CN(C)C=O.N#CCc1ccc(Br)cc1F>>CC(C)(C#N)c1ccc(Br)cc1F,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US04973351,CCOC(=O)C(=N)SCC.Cc1c(N)cccc1F>>CCOC(=O)C(=N)Nc1cccc(F)c1C,,ClCCl,,CCCCCC,,val
US04761419,Cc1nc2ccc(Cl)cc2c(-c2ccc(F)cc2)c1CO>>Cc1nc2ccc(Cl)cc2c(-c2ccc(F)cc2)c1C=O,,CS(C)=O,ClCCl,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20150344431A1,CC1CC(C)(C)c2cccc(N)c21.Cl>>CC1CC(C)(C)c2cccc(N)c21.Cl,,Cc1ccccc1,,,,val
US20120022060A1,Clc1cnc2[nH]c3c(c2c1)CNCC3.N#Cc1ccc(S(=O)(=O)Cl)cc1>>N#Cc1ccc(S(=O)(=O)N2CCc3[nH]c4ncc(Cl)cc4c3C2)cc1,,c1ccncc1,,O,,val
US06559164B1,CCOC(C)=O.Cn1cc(C2=C(c3cn(C)c4cc([N+](=O)[O-])ccc34)C(=O)N(COC(=O)C3CCNCC3)C2=O)c2ccccc21>>CC(=O)O.Cn1cc(C2=C(c3cn(C)c4cc([N+](=O)[O-])ccc34)C(=O)N(COC(=O)C3CCNCC3)C2=O)c2ccccc21,,CCOC(C)=O,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US06927294B1,CC(=O)O[C@@H]1CN[C@H](c2ccco2)[C@H](OC(C)=O)[C@H]1OC(C)=O.O=C(Cl)OCc1ccccc1>>CC(=O)O[C@@H]1CN(C(=O)OCc2ccccc2)[C@H](c2ccco2)[C@H](OC(C)=O)[C@H]1OC(C)=O,,ClCCl,,CCN(CC)CC,,val
US20040102450A1,CC#N.N#Cc1ccc(CN2CCC(Cc3nc4ccc(Cl)cc4[nH]3)CC2=O)cc1N>>Cc1nc(N)c2ccc(CN3CCC(Cc4nc5ccc(Cl)cc5[nH]4)CC3=O)cc2n1,,C1COCCO1,,Cl,Cl,val
US20140309452A1,CCOC(C#CCCCCCCCl)OCC>>O=CC#CCCCCCCCl,Cc1ccc(S(=O)(=O)O)cc1,C1CCOC1,,O,,val
US20030027743A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.CCCCN>>CCCCNC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20040220235A1,O=[N+]([O-])c1ccc(C=C/C=C/c2ccc(Cl)c(Cl)c2)cc1>>Nc1ccc(CCCCc2ccc(Cl)c(Cl)c2)cc1,[Ni],C1CCOC1,,CO,,val
US20110230462A1,Cc1nc(-c2cnc3c(n2)c(C(=O)N[C@@H](C(=O)N2CC(C#N)C2)C2CC2)cn3COCC[Si](C)(C)C)cn1-c1ccccc1>>Cc1nc(-c2cnc3[nH]cc(C(=O)N[C@@H](C(=O)N4CC(C#N)C4)C4CC4)c3n2)cn1-c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160272617A1,CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](C(=O)N[C@@H](Cc2ccc(-c3ccc(C(=O)O)cc3Cl)cc2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)CC1.COCCOCCOCCOCCN>>COCCOCCOCCOCCNC(=O)c1ccc(-c2ccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CNC(=O)OC(C)(C)C)CC3)C(=O)Nc3ccc(-c4nn[nH]n4)cc3)cc2)c(Cl)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130116235A1,CC(C)(C)OC(=O)N1CCN(c2ccc(N)cn2)CC1.Cn1cc(Br)nc(Br)c1=O>>Cn1cc(Br)nc(Nc2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)nc2)c1=O,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20130225552A1,COC(=O)/C=C/c1cccnc1N>>Oc1ccc2cccnc2n1,,CCO,,C,C[O-].[Na+],val
US04590082,O=C(O)CCS.OC1CCCCC1>>O=C(CCS)OC1CCCCC1,,CCOCC,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccco2)c1Br.OCCCc1ccccc1>>Nc1nc(OCCCc2ccccc2)c(Br)c(-c2ccco2)n1,,C1COCCO1,,C1CCC2=NCCCN2CC1,,val
US20090325925A1,CCOC(=O)C1SC(N2CCOCC2)=C(C#N)C1c1ccc(OC)cc1>>CCOC(=O)c1sc(N2CCOCC2)c(C#N)c1-c1ccc(OC)cc1,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20130116285A1,COc1cc(Cl)ccc1Oc1ccc(C#N)cc1-c1cccnc1OC.OO>>COc1cc(Cl)ccc1Oc1ccc(C(N)=O)cc1-c1cccnc1OC,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130253029A1,CON=C(c1ccc(Cl)c(Cl)c1)C1C2CN(C(=O)OC(C)(C)C)CC21.Cl>>CON=C(c1ccc(Cl)c(Cl)c1)C1C2CNCC21.Cl,,ClCCl,,CCCCCC,,val
US20140371232A1,COC(=O)c1c(O)cc(OC)cc1/C=C/c1ccccc1.O=S(=O)(Cl)Cl>>COC(=O)c1c(O)cc(OC)c(Cl)c1/C=C/c1ccccc1,,CCOCC,,,,val
US20160272595A1,CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2cc(CN3CCNCC3)c(Br)cc2c1=O.CS(=O)(=O)Cl>>CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2cc(CN3CCN(S(C)(=O)=O)CC3)c(Br)cc2c1=O,,c1ccncc1,,CCOC(C)=O,[Cl-].[NH4+],val
US20030045558A1,CCO.Cc1cc(OCCc2nc(-c3ccccc3)oc2C)ccc1OC(C)(C)C(=O)O>>CCOC(=O)C(C)(C)Oc1ccc(O)cc1C,[Pd],,,[H][H],,val
US05142056,CC(C)(C)OC(=O)NC(Cc1ccccc1)C(O)C(N)Cc1ccccc1>>NC(Cc1ccccc1)C(O)C(N)Cc1ccccc1,,C1COCCO1,,Cl,,val
US04340765,CCOC(OCC)/C(C)=C/CBr.COc1cccc(O)c1>>CCOC(OCC)/C(C)=C/COc1cccc(OC)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20070060607A1,N#Cc1cccc(CBr)c1.Oc1cccc(O)c1>>N#Cc1cccc(COc2cccc(O)c2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100172867A1,Cc1ccc(S(=O)(=O)N2CCC(=NO)C(=O)c3ccccc32)cc1>>Cc1ccc(S(=O)(=O)N2CCC(N)C(O)c3ccccc32)cc1,,CO,,[H][H],,val
US20090233920A1,CC(C)(C)C(=O)Cl.COCCCn1cc(CN(C(=O)[C@@H]2C[C@H](NCC3CC3)CN(C(=O)OCC3c4ccccc4-c4ccccc43)C2)C2CC2)c2ccccc21>>COCCCn1cc(CN(C(=O)[C@H]2CNC[C@@H](N(CC3CC3)C(=O)C(C)(C)C)C2)C2CC2)c2ccccc21,,CC#N,,,,val
US20100137446A1,CC(=O)Cl.COc1ccc2cccc(C(F)CN)c2c1>>COc1ccc2cccc(C(F)CNC(C)=O)c2c1,,CCOC(C)=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20050256140A1,CC(=O)OCC(=O)Cl.Nc1c(S)ncnc1S>>OCc1nc2c(S)ncnc2s1,,c1ccncc1,,,,val
US05538966,CCOC(=O)C1=Cc2ccsc2S(=O)(=O)N1c1cccc(OC)c1>>COc1cccc(N2C(CO)=Cc3ccsc3S2(=O)=O)c1,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20100280048A1,COC(=O)c1ncc(C)n(-c2cccc(C(F)(F)F)c2)c1=O.O=C1CCC(=O)N1Br>>COC(=O)c1nc(Br)c(C)n(-c2cccc(C(F)(F)F)c2)c1=O,,CN(C)C=O,,O,,val
US06147063,CCc1ccc(Cl)c(NC#N)c1.CCc1cccc(N)c1.CS(=O)(=O)O>>CCc1cccc(NC(=N)Nc2cc(CC)ccc2Cl)c1.CS(=O)(=O)O,,Clc1ccccc1,,,,val
US05484917,CC(C)(C)NC(=O)CN1C(=O)C(N)CC(c2ccccc2)c2ccccc21.Cc1cccc(N=C=O)c1>>Cc1cccc(NC(=O)NC2CC(c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1,,ClCCl,,,,val
US20150133432A1,CCOC(=O)CN=C=O.COCOc1ccc(-c2cc(CN3CC(C)(C)NCC3(C)C)c3c(C)nn(C4CCCCO4)c3n2)cc1>>CCOC(=O)CNC(=O)N1CC(C)(C)N(Cc2cc(-c3ccc(OCOC)cc3)nc3c2c(C)nn3C2CCCCO2)CC1(C)C,,O,,C1CCOC1,CCN(C(C)C)C(C)C,val
US04000153,C=O.Cc1nncn1-c1ccc(C(F)(F)F)cc1C(=O)c1ccccc1Cl>>Cc1nnc(CO)n1-c1ccc(C(F)(F)F)cc1C(=O)c1ccccc1Cl,,Cc1ccccc1C,,,,val
US20150031733A1,CCOc1cccc(-n2nn[nH]c2=O)c1C.COS(=O)(=O)OC>>CCOc1cccc(-n2nnn(C)c2=O)c1C,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110172212A1,CCCN(CCCCNCc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1)CC(=O)OCC.CCOC(=O)CBr>>CCCN(CCCCN(CC(=O)OCC)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1)CC(=O)OCC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20100204472A1,CCOC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(C(N)=S)cc3OC)ccc21.CCOC(CBr)OCC>>CCOC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(-c4nccs4)cc3OC)ccc21,O,CCO,,,,val
US05300479,COC(=O)c1cc(NC(C)=O)c([N+](=O)[O-])cc1C(=O)OC.Cc1ccc(S(=O)(=O)O)cc1>>COC(=O)c1cc2nc(C)[nH]c2cc1C(=O)OC.Cc1ccc(S(=O)(=O)O)cc1,[Pt],Cc1ccccc1,,CO,,val
US05124330,Cc1cccc(CN2CCNCC2)c1.Clc1ccc(C(Cl)c2cccc(OCc3ccccc3)c2)cc1>>Cc1cccc(CN2CCN(C(c3ccc(Cl)cc3)c3cccc(OCc4ccccc4)c3)CC2)c1,,CCOCC,Cc1ccccc1,,,val
US06015818,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.COc1cc(C=O)ccc1C(=O)O>>COC(=O)C=Cc1ccc(C(=O)O)c(OC)c1,,C1CCOC1,,,,val
US20160176816A1,CN1CC[C@@H](COC(=O)Nc2ccccc2Br)C1.OCc1cccc(B(O)O)c1>>CN1CC[C@@H](COC(=O)Nc2ccccc2-c2cccc(CO)c2)C1,,CCO,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US04014904,CC(=O)Cl.CN(C)S(=O)(=O)Oc1ccc2c(c1)C(C)(C)C(O)O2>>CC(=O)OC1Oc2ccc(OS(=O)(=O)N(C)C)cc2C1(C)C,,CCOCC,,CCN(CC)CC,,val
US20110251181A1,C[C@@H]1CCc2ncnc(-c3ccc(C(=O)N(CCNC(=O)OC(C)(C)C)Cc4ccc(Cl)cc4)cc3)c21>>C[C@@H]1CCc2ncnc(-c3ccc(C(=O)N(CCN)Cc4ccc(Cl)cc4)cc3)c21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080176872A1,C[C@H](N)c1ccc(F)cc1.O=[N+]([O-])c1cc(F)c(F)c(F)c1Nc1cc(C2CC2)[nH]n1>>C[C@H](Nc1c(F)cc([N+](=O)[O-])c(Nc2cc(C3CC3)[nH]n2)c1F)c1ccc(F)cc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20090124598A1,CC1(C)CC2CC(C)(CN2C(=O)c2ccc(CN)cc2)C1.O=S(=O)(Cl)CCCCl>>CC1(C)CC2CC(C)(CN2C(=O)c2ccc(CN3CCCS3(=O)=O)cc2)C1,,ClCCl,,[H-].[Na+],,val
US20110172433A1,N=C1SCCN1Cc1cnc(Cl)s1.O=C(Cl)c1ccccc1>>O=C(N=C1SCCN1Cc1cnc(Cl)s1)c1ccccc1,,ClC(Cl)Cl,O,O=C([O-])[O-].[Na+].[Na+],,val
US06258854B1,CC(=O)[O-].COc1ccc(C(=O)CBr)cc1>>COc1ccc(C(=O)COC(C)=O)cc1,,CO,,O,,val
US20160052870A1,COC(=O)c1ccc(OC)c(NC(=O)C(C)C)c1>>COc1ccc(C(=O)O)cc1NC(=O)C(C)C,,O,,[Li+].[OH-],,val
US20030153752A1,CCOP(=O)(CC(=O)O)OCC.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2C1CCC(=O)CC1>>Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2C1CCC(=CC(=O)O)CC1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US04409229,CC(=O)Cl.c1ccc(C2SC3(CCNCC3)c3ccccc32)cc1>>CC(=O)N1CCC2(CC1)SC(c1ccccc1)c1ccccc12,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20040006119A1,Cc1cscc1N=C=S.Nc1cccc(C(=O)O)c1N>>Cc1cscc1NC(=S)Nc1cccc(C(=O)O)c1N,,C1CCOC1,,CO,ClCCl,val
US20070032515A1,COC(=O)c1cc([N+](=O)[O-])cc(OC(=O)c2ccccc2)c1OCCBr>>COC(=O)c1cc([N+](=O)[O-])cc2c1OCCO2,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20040198790A1,C=CCOC(=O)OCc1ccc(C#N)cc1C(=O)O.O=C(Cl)C(=O)Cl>>C=CCOC(=O)OCc1ccc(C#N)cc1C(=O)Cl,,Cc1ccccc1,ClCCl,CN(C)C=O,,val
US20110269738A1,CC(C)Oc1ncc(-c2nc(Br)ns2)cc1Cl.CCc1c(/C=C/OC)cccc1B1OC(C)(C)C(C)(C)O1>>CCc1c(/C=C/OC)cccc1-c1nsc(-c2cnc(OC(C)C)c(Cl)c2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20140081017A1,CCOC(=O)Cc1csc(C#CCCc2ccccc2)n1>>CCOC(=O)Cc1csc(CCCCc2ccccc2)n1,[Pd],CCO,,,,val
US20030149027A1,CC(C)(C)OC(=O)N1Cc2ccc(Nc3ccccc3[N+](=O)[O-])cc2C1>>CC(C)(C)OC(=O)N1Cc2ccc(Nc3ccccc3N)cc2C1,[Pd],CO,,,,val
US20150053938A1,Clc1ccc(-n2c3ccccc3c3ccc4c5ccccc5[nH]c4c32)cc1.Clc1nc(-c2ccccc2)nc(-c2ccccc2)n1>>Clc1ccc(-n2c3ccccc3c3ccc4c5ccccc5n(-c5nc(-c6ccccc6)nc(-c6ccccc6)n5)c4c32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US04824958,CN(C)C(=S)Cl.COC(=O)c1sc(C)c(Br)c1O>>COC(=O)c1sc(C)c(Br)c1OC(=S)N(C)C,,CN(C)C=O,,C1CN2CCN1CC2,,val
US20130317026A1,Cc1cc(C)c(CNC(=O)c2cc(Br)nc3c2cnn3C(C)C)c(=O)[nH]1.OCc1ccc(B(O)O)cc1>>Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(CO)cc3)nc3c2cnn3C(C)C)c(=O)[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20120115841A1,CS(=O)(=O)Cl.OCc1cnc(Br)s1>>CS(=O)(=O)OCc1cnc(Br)s1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,N#N,val
US20050090533A1,COc1cc(OC)cc(C(C)(C)C(=O)N(C)c2cnc(Cl)cc2-c2ccccc2C)c1>>Cc1ccccc1-c1cc(Cl)ncc1N(C)C(=O)C(C)(C)c1cc(O)cc(O)c1,,O,,ClCCl,,val
US20150284387A1,CCOC(=O)c1cc(Cl)nc2c1c(C)nn2Cc1ccc(Oc2ccccc2)cc1.NCc1ccco1>>CCOC(=O)c1cc(NCc2ccco2)nc2c1c(C)nn2Cc1ccc(Oc2ccccc2)cc1,,O,,CC(C)O,,val
US20020052512A1,COC(=O)[C@H](CNC(=O)c1ccccc1)NC(=O)c1ccc(CN=[N+]=[N-])cc1Cl>>COC(=O)[C@H](CNC(=O)c1ccccc1)NC(=O)c1ccc(CN)cc1Cl,[Pd],CCO,,,,val
US20090156612A1,Nc1ccc(OC(F)F)cc1.O=C(O)C[C@H]1NC(=O)CN(Cc2ccccc2)C1=O>>O=C(C[C@H]1NC(=O)CN(Cc2ccccc2)C1=O)Nc1ccc(OC(F)F)cc1,,c1ccncc1,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20120171245A1,Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(NCC4CCCCC4O)n3)c3cc(Cl)cnc32)cc1>>OC1CCCC[C@@H]1CNc1nc(-c2c[nH]c3ncc(Cl)cc23)ncc1F,,C1CCOC1,,[Li+].[OH-],,val
US20020042431A1,CN(C(=O)OCc1ccccc1)C1CCC(OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1c1ccccc1>>CNC1CCC(OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1c1ccccc1,[Pd],CO,,CCOC(C)=O,,val
US20140018365A1,CCOC(=O)c1nn(-c2ccc(F)cc2)cc1OC>>COc1cn(-c2ccc(F)cc2)nc1C(=O)O,,CC(=O)O,ClCCl,Cl,[K+].[OH-],val
US20050153231A1,CC(S)CC(=O)O.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=C([O-])O.OCCO>>CC(S)CC(=O)OCCOC(=O)CC(C)S,,Cc1ccccc1,,O,[Na],val
US20090209536A1,CC(C)(C)c1ccc(N)cc1.COc1cc2nc(Cl)nc(N3CCCC3)c2cc1OC>>COc1cc2nc(Nc3ccc(C(C)(C)C)cc3)nc(N3CCCC3)c2cc1OC,,CCO,,,,val
US20130114009A1,Fc1cc(F)cc(-c2ccc(Br)cc2F)c1.O=C=O>>O=C(O)c1ccc(-c2cc(F)cc(F)c2)c(F)c1,,Cl,,C1CCOC1,,val
US20070032530A1,Cc1cc(O)ccc1CCCCn1ccnn1.ClCc1cccc(-c2cccc(Cl)c2)n1>>Cc1cc(OCc2cccc(-c3cccc(Cl)c3)n2)ccc1CCCCn1ccnn1,,CN(C)C=O,,O,[H-].[Na+],val
US05488055,CCn1ncc2c(NCC3CCCCC3)c3cc(O)ccc3nc21.ClCCN1CCOCC1>>CCn1ncc2c(NCC3CCCCC3)c3cc(OCCN4CCOCC4)ccc3nc21,,CS(C)=O,,Cl,[K+].[OH-],val
US20070129346A1,CC(C)C(=O)N(C1CCCCC1)[C@@H]1CCN(NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)OC(C)(C)C)C1.O=C(O)C(F)(F)F>>CC(C)C(=O)N(C1CCCCC1)[C@@H]1CCN(NC(=O)[C@H](N)Cc2ccc(Cl)cc2)C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20150291530A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccnc(C(F)(F)F)c1>>O=S(=O)(Oc1ccnc(C(F)(F)F)c1)C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060025421A1,CN1CCN(c2ncccc2C=C2OCCN(c3ccc(C4CCOCC4)cc3)C2=O)CC1>>CN1CCN(c2ncccc2CC2OCCN(c3ccc(C4CCOCC4)cc3)C2=O)CC1,[Pd],CCO,,,,val
US20140194437A1,CC(C)(C)c1nc(CCO)cc(N2CCNCC2)n1.O=C(Cl)OCc1ccccc1>>CC(C)(C)c1nc(CCO)cc(N2CCN(C(=O)OCc3ccccc3)CC2)n1,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US06599917B1,O=C1CCC(=O)N1I.c1ccc(Cc2cccc(N3C[C@H]4OCCO[C@@H]4C3)n2)cc1>>Ic1ccc(N2C[C@H]3OCCO[C@@H]3C2)nc1Cc1ccccc1,,O,,CN(C)C=O,,val
US20050282812A1,CCC1CN(C(C#N)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2N1.CCOC(=O)Cl>>CCOC(=O)N1c2ccccc2N(C(C#N)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1CC,,ClCCl,,c1ccncc1,,val
US20100292225A1,CC1(C)OB(c2cncc(C=O)c2)OC1(C)C.COc1cc(Br)ccc1C#N>>COc1cc(-c2cncc(C=O)c2)ccc1C#N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US06740662B1,CCNc1nc(C(OC)OC)ccc1C(=O)c1cccc(Cl)c1.CCOC(=O)C(Cl)CCC(=O)[O-]>>CCn1c(=O)c(CCC(=O)OC)c(-c2cccc(Cl)c2)c2ccc(C=O)nc21,,CN(C)C=O,,[H-].[Na+],,val
US20020072528A1,CC(=O)OC(C)=O.Nc1cnc2ccccc2c1O>>Cc1nc2cnc3ccccc3c2o1,,O,,[Na+].[OH-],,val
US20140163035A1,CON=C1COc2c1ccnc2Cl>>NC1COc2c1ccnc2Cl,,C1CCOC1,,B,,val
US20110021351A1,CS(=O)(=O)Cl.Oc1nc2nccnc2c(O)c1-c1ncc(Cl)cc1Cl>>CS(=O)(=O)Oc1c(-c2ncc(Cl)cc2Cl)c(=O)[nH]c2nccnc12,,Cl,ClCCl,CCN(C(C)C)C(C)C,,val
US20120165519A1,COCCN(C)S(=O)(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.COc1cc2c(cc1N)CCN(CC(=O)N(C)C)CC2>>COCCN(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cc3c(cc2OC)CCN(CC(=O)N(C)C)CC3)ncc1Cl,,CC(=O)N(C)C,,,,val
US20040167123A1,CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(N)ccc3N2)c(O)c2cccnc21.NCc1ccco1.O=C=NS(=O)(=O)Cl>>CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(NS(=O)(=O)NC(=O)NCc4ccco4)ccc3N2)c(O)c2cccnc21,,ClCCl,,CCN(CC)CC,,val
US04395406,CN(C)CCCl.O=c1ncc(Cl)c[nH]1>>CN(C)CCn1cc(Cl)cnc1=O,,CN(C)C=O,,[K],,val
US20080234300A1,CC#N.COCCOc1cc(N=CN(C)C)c(C(=O)OC)cc1OC>>COCCOc1cc2ncc(C#N)c(O)c2cc1OC,,C1CCOC1,,CC(=O)O,[Li]CCCC,val
US20070232627A1,Nc1ccc(Br)cn1.O=C(Cl)c1ccc(Cl)c([N+](=O)[O-])c1>>O=C(Nc1ccc(Br)cn1)c1ccc(Cl)c([N+](=O)[O-])c1,,Cc1ccccc1,,Cl,,val
US20150307449A1,CCOC(=O)COc1cccc(S(=O)(=O)n2cc(CN(C)C(=O)OC(C)(C)C)cc2C2=CCCCC2)c1>>CN(Cc1cc(C2=CCCCC2)n(S(=O)(=O)c2cccc(OCC(=O)O)c2)c1)C(=O)OC(C)(C)C,,O,,C1CCOC1,[Li+].[OH-],val
US20080146606A1,CC(C)(N)CO.O=S(=O)(Cl)c1ccc(Br)cc1>>CC(C)(CO)NS(=O)(=O)c1ccc(Br)cc1,,ClCCl,,CCN(CC)CC,,val
US20160244449A1,CC(C)(C)OC(=O)N1CC(I)C1.CC1(C)OB(c2cn[nH]c2)OC1(C)C>>CC(C)(C)OC(=O)N1CC(n2cc(B3OC(C)(C)C(C)(C)O3)cn2)C1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080015199A1,COc1cc(COCCOC2CCCCO2)c(F)c(C(OC)OC)c1>>COc1cc(C=O)c(F)c(COCCO)c1,,C1CCOC1,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US05155196,C#CCCl.Oc1ccc(O)cc1>>C#CCOc1ccc(O)cc1,,CS(C)=O,,,,val
US20040043978A1,CCOC(=O)N1CCC(=O)CC1.COC(OC)N(C)C>>CCOC(=O)N1CCC(=O)C(=CN(C)C)C1,,O,,,,val
US20030232848A1,C1CCOC1.CC(=O)N(C)C.CC(C)c1ccc(S(=O)(=O)Nc2c(-c3ccc4c(c3)OCO4)c(OCCO)nn2C)nc1.CS(=O)(=O)c1cnc(Cl)nc1>>CC(=O)[O-].CC(C)c1ccc(S(=O)(=O)Nc2c(-c3ccc4c(c3)OCO4)c(OCCOc3ncc(S(C)(=O)=O)cn3)nn2C)nc1.[NH4+],,C1CCOC1,CC(=O)N(C)C,[H-].[Na+],,val
US05698584,CCOC(=O)COc1ccc(OC)c(Cl)c1>>COc1ccc(OCC(=O)O)cc1Cl,,C1CCOC1,CO,[Na+].[OH-],,val
US20120309966A1,CC(=O)OC(C)=O.O=C(NCc1nccnc1Cl)[C@@H]1CC[C@H](O)CC1>>CC(=O)O[C@H]1CC[C@@H](C(=O)NCc2nccnc2Cl)CC1,CN(C)c1ccncc1,c1ccncc1,,,,val
US05585394,CCOc1ccc2[nH]c(=O)n(C3CCCCC3)c2c1.COc1cc(C(=O)OCc2ccccc2)ccc1S(=O)(=O)Cl>>CCOc1ccc2c(c1)n(C1CCCCC1)c(=O)n2S(=O)(=O)c1ccc(C(=O)OCc2ccccc2)cc1OC,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20030158409A1,COc1cc(CO)ccn1.O=S(Cl)Cl>>COc1cc(CCl)ccn1,,ClC(Cl)Cl,,,,val
US20090325937A1,C=Cc1cc2c(nn1)Nc1ccccc1NC2=O>>CCc1cc2c(nn1)Nc1ccccc1NC2=O,[Pd],CO,,[H][H],,val
US20060229286A1,CC(C)(C)c1cc(N)n[nH]1.CCOC(=O)C(C(C)=O)C(C)=O>>Cc1nc2cc(C(C)(C)C)nn2c(C)c1C(=O)O,,CC(=O)O,,,,val
US04853389,CSc1ncc(S(=O)(=O)NC(=O)NC(C)C)c(Nc2cccc(C)c2)n1.O=C(OO)c1cccc(Cl)c1>>Cc1cccc(Nc2nc(S(C)=O)ncc2S(=O)(=O)NC(=O)NC(C)C)c1,,ClCCl,,,,val
US20070093488A1,NC1CCCC1.O=C(Nc1nc2ccc(OS(=O)(=O)c3ccc(F)cc3)cc2s1)C1CC1>>O=C(Nc1nc2ccc(OS(=O)(=O)c3ccc(NC4CCCC4)cc3)cc2s1)C1CC1,,CN1CCCC1=O,,,,val
US20100227990A1,Br[Mg]c1ccccc1.C=CCCOc1cc(-c2cccc(C=Nc3c(C(C)C)cccc3C(C)C)n2)c(C)cc1C>>C=CCCOc1cc(-c2cccc(C(Nc3c(C(C)C)cccc3C(C)C)c3ccccc3)n2)c(C)cc1C,,Cc1ccccc1,,,,val
US20050065188A1,C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)OC(C)(C)C)cc1>>C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060167107A1,CCOc1ccccc1C(=O)Cl.Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1>>CCOc1ccccc1C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,,val
US06177422B1,Cc1ccc(N2CCNCC2)cc1.O=CC1=CCC2NC(=O)COC2=C1>>Cc1ccc(N2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060142357A1,O=C(NC(=S)NC1CCCCCCC1)c1ccccc1>>NC(=S)NC1CCCCCCC1,,CO,O,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US04542142,CC1(C)[C@@H](/C=C\C(=O)O)[C@H]1C(=O)O[C@H](C#N)c1ccc(F)c(Oc2ccccc2)c1.O=S(Cl)Cl>>CC1(C)[C@@H](/C=C\C(=O)Cl)[C@H]1C(=O)O[C@H](C#N)c1ccc(F)c(Oc2ccccc2)c1,,ClCCl,,,,val
US20110257151A1,COC(=O)c1ccc2c(c1F)NC(c1cccc(Br)c1)C(C)(C)C2O>>COC(=O)c1ccc2c(c1F)NC(c1cccc(Br)c1)C(C)(C)C2,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20030176418A1,C[C@@H](CBr)CO[Si](C)(C)C(C)(C)C.O=C1CSc2ccccc2N1>>C[C@H](CO[Si](C)(C)C(C)(C)C)CN1C(=O)CSc2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05665718,COCCNCCOC.O=C1c2c(Cl)cccc2-n2cnc(-c3noc(CCl)n3)c2[C@@H]2CCN12>>COCCN(CCOC)Cc1nc(-c2ncn3c2[C@@H]2CCN2C(=O)c2c(Cl)cccc2-3)no1,,CN(C)C=O,,,,val
US20120053188A1,COC(=O)CCCCCCC(=O)Nc1cc(-c2ccccc2)ccc1[N+](=O)[O-]>>COC(=O)CCCCCCC(=O)Nc1cc(-c2ccccc2)ccc1N,[Pd],CO,,O=C[O-].[NH4+],,val
US20120101083A1,CCOC(C)=O.Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCNC2>>COCCN1CCc2c(ccc(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)c2C)C1,,CCOC(C)=O,CN(C)C=O,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US04316022,CC(=O)Cl.c1ccc2c(c1)NNc1nncn1-2>>CC(=O)N1Nc2nncn2-c2ccccc21,,Cc1ccccc1,,,,val
US20060205718A1,C1CCOC1.CCOc1cc(C(=O)OC)cc(N)c1Cl.O=[Mn]=O>>CCOc1cc(C=O)cc(NC(C)=O)c1Cl,O=[Mn]=O,,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140094604A1,CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(F)c(F)c2)c2nnn([C@@H]3C[C@H](OCC(=O)O)[C@H]4OC(C)(C)O[C@H]43)c2n1>>CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(F)c(F)c2)c2nnn([C@@H]3C[C@H](OCCO)[C@H]4OC(C)(C)O[C@H]43)c2n1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120277207A1,COC(=O)C1Cc2cc(/C=C/C(=O)OC(C)(C)C)cnc2NC1=O>>COC(=O)C1Cc2cc(/C=C/C(=O)O)cnc2NC1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04988686,NCc1ccco1.O=c1cc(CO)occ1OC(c1ccccc1)c1ccccc1>>O=c1cc(CO)n(Cc2ccco2)cc1OC(c1ccccc1)c1ccccc1,,CO,ClC(Cl)Cl,,,val
US20160159819A1,COC(C(=O)Cl)P(=O)(OC)OC.Cn1nc(N)cc1C(C)(C)C>>COC(C(=O)Nc1cc(C(C)(C)C)n(C)n1)P(=O)(OC)OC,,ClCCl,,CCN(CC)CC,O,val
US06150412,COc1ccc(CCCCCC(=O)O)cc1OC.O=[N+]([O-])O>>COc1cc(CCCCCC(=O)O)c([N+](=O)[O-])cc1OC,,CC(=O)O,,,,val
US05276048,BrCc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.CCCCc1nc(-n2cccc2)c(C#N)[nH]1>>CCCCc1nc(-n2cccc2)c(C#N)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20110124618A1,CNC.CS(=O)(=O)OCCCOc1cccc(-c2cc(C(=O)N3CNC(=O)C3)nn2-c2cccc(Cl)c2)c1>>CN(C)CCCOc1cccc(-c2cc(C(=O)N3CNC(=O)C3)nn2-c2cccc(Cl)c2)c1.O=CO,,CCO,,C1CCOC1,,val
US20130041150A1,CC(=O)O.C[C@@H](N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F)c1ccccc1.O=P(O)(O)O>>N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F.O.O=P(O)(O)O,[Pd],CO,,[H][H],,val
US20140256729A1,CC(C)(C)OC(=O)NC1CCC(N[C@@H]2C[C@H]2c2ccc(Nc3cccc(C#N)c3)nc2)CC1>>N#Cc1cccc(Nc2ccc([C@@H]3C[C@H]3NC3CCC(N)CC3)cn2)c1,,C1COCCO1,,Cl,,val
US20130345444A1,C[C@@H](N)c1ccccc1.O=C(O)Cc1coc2cc(O)ccc12>>C[C@@H](N)c1ccccc1.O=C(O)C[C@@H]1COc2cc(O)ccc21,,CO,,,,val
US20140288123A1,Cc1nc(C)c(C#N)c(O)n1>>Cc1nc(C)c(CN)c(O)n1,,O,,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20160016908A1,CNC.O=Cc1cccc(Br)n1>>CN(C)Cc1cccc(Br)n1,,ClCCl,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05189042,CCC1C=C(C)C(F)C(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(N=[N+]=[N-])C(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC>>CCC1C=C(C)C(F)C(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(N)C(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC,,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05936123,COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)C)cc1C(C)C.O=C(O)/C=C\C(=O)O>>COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)C)cc1C(C)C.O=C(O)/C=C\C(=O)O,,CC(C)O,,,,val
US20160130268A1,C[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H](C)N1.O=C(NCCBr)OCc1ccccc1>>C[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H](C)N1CCNC(=O)OCc1ccccc1,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20050020684A1,COCC(=O)OC.COc1cc(C=O)ccc1OCc1ccccc1>>COC(=O)C(OC)C(O)c1ccc(OCc2ccccc2)c(OC)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US05324709,CC(=O)Cl.O=C(COc1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1Cl)OC1COCC1O>>CC(=O)OC1COCC1OC(=O)COc1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1Cl,,c1ccccc1,,CCN(CC)CC,,val
US20080076740A1,CC(C)(C)[Si](C)(C)OCCNCc1ccc(F)cc1.COc1ccc(COc2nc(-c3ccc(C)cc3)nc(C(=O)O)c2OCc2ccc(OC)cc2)cc1>>COc1ccc(COc2nc(-c3ccc(C)cc3)nc(C(=O)N(CCO[Si](C)(C)C(C)(C)C)Cc3ccc(F)cc3)c2OCc2ccc(OC)cc2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100240656A1,CCCCn1c(Sc2ccc(C(F)(F)F)cc2)nc2c(=O)[nH]cnc21.COCCOCCl>>CCCCn1c(Sc2ccc(C(F)(F)F)cc2)nc2c(=O)n(COCCOC)cnc21,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20130040931A1,CC(C)(C)CCc1cccc(C(=O)N2CCCC2)c1-c1ccc2nc(N)c(N3CCOCC3)cc2c1.O=CO>>CC(C)(C)CC(=O)c1cccc(C(=O)N2CCCC2)c1-c1ccc2nc(N)c(N3CCOCC3)cc2c1,,ClCCl,,,,val
US20110152300A1,CC(C)C=NO.CS(=O)(=O)c1ncc(F)c(NCc2ccccc2F)n1>>CC(C)C=NOc1ncc(F)c(NCc2ccccc2F)n1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20140336177A1,CC(C)(C)C(=O)Nc1ccc(CC(=O)[O-])nn1.C[Si](C)(C)C=[N+]=[N-]>>COC(=O)Cc1ccc(N)nn1,,Cl,O,CCOCC,,val
US20120157432A1,CC(=O)c1ncccc1Cl>>CC(O)c1ncccc1Cl,,CO,,[BH4-].[Na+],,val
US20050070720A1,OCCCCn1c(S)nnc1C12CC3CC(CC(C3)C1)C2>>C1CCn2c(nnc2C23CC4CC(CC(C4)C2)C3)SC1,,Cl,,O=C([O-])[O-].[Na+].[Na+],,val
US20150361100A1,CC(c1cc2ccccn2c1N1CCCC1=O)n1nc(I)c2c(N)ncnc21.OB(O)c1cc(O)cc(F)c1>>CC(c1cc2ccccn2c1N1CCCC1=O)n1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US05200109,CCCCCCCCCCc1ccc(C(=O)OCC)cc1.NN>>CCCCCCCCCCc1ccc(C(=O)NN)cc1,,O,,CCO,,val
US06093716,CCOC(CC)(OCC)OCC.Nc1cc([N+](=O)[O-])ccc1O>>CCc1nc2cc([N+](=O)[O-])ccc2o1,Cc1ccc(S(=O)(=O)O)cc1,CCO,,,,val
US20090298807A1,CC(C)CC(N)=S.CCOC(=O)C(=O)CBr>>CCOC(=O)c1csc(CC(C)C)n1,,CCO,,,,val
US20150299156A1,CC#N.O.Oc1ccc(C(F)(F)F)cc1.Oc1cccc(Br)c1>>OCCCOc1ccc(C(F)(F)F)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050075334A1,N#Cc1c(Cl)ccc2[nH]c(S)nc12.O.[OH-]>>O=C(O)c1c(Cl)ccc2[nH]c(S)nc12,,O,,CCO,,val
US20060100194A1,COC(OC)N(C)C.O=C1CCC(=O)c2cc(I)ccc2N1>>CN(C)C=C1CC(=O)Nc2ccc(I)cc2C1=O,,C1CCOC1,,CCOCC,,val
US20110201663A1,CCOC(=O)Cc1cc(F)c(N2C(=O)c3c(c(OCC)c4ccccc4c3OCC)C2=O)c(F)c1>>CCOC(=O)Cc1cc(F)c(N2C(=O)c3c(c(OCC)c4ccccc4c3OCC)C2O)c(F)c1,,C1CCOC1,CO,[BH4-].[Na+],,val
US20100063101A1,COc1ccc(-c2nc3cc(F)c(F)cc3n2C(C(=O)N(Cc2ccccc2)N=O)C2CCCCC2)c(OC)n1.OO>>COc1ccc(-c2nc3cc(F)c(F)cc3n2C(C(=O)O)C2CCCCC2)c(OC)n1,,C1CCOC1,O,CC(=O)O,[Li+].[OH-],val
US20070093454A1,CC(C)COC(=O)N1CCNCC1.Clc1cc(Cl)ncn1>>CC(C)COC(=O)N1CCN(c2cc(Cl)ncn2)CC1,,O,,CCN(CC)CC,CN(C)C=O,val
US20120022109A1,COCc1cc(-c2nc(-c3ccc(CN(C)CC(=O)OC(C)(C)C)c(Cl)c3)no2)ccc1-c1ccccc1C>>COCc1cc(-c2nc(-c3ccc(CN(C)CC(=O)O)cc3Cl)no2)ccc1-c1ccccc1C,,C1COCCO1,,Cl,,val
US20120022077A1,COC(=O)/C=C/c1cccc(CO)n1>>COC(=O)CCc1cccc(CO)n1,,CC(C)O,,,,val
US20110201608A1,CCN=C=O.CN1CCN(c2ccc(-c3cc4ncccc4c(N(C)C4CCCN4)n3)cc2)CC1>>CCNC(=O)N1CCCC1CNc1nc(-c2ccc(N3CCN(C)CC3)cc2)cc2ncccc12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130072467A1,CC(C)[C@H](NC1=NC(=O)SC1)C(=O)N1CCOCC1.O=CC1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1>>CC(C)[C@H](NC1=NC(=O)S/C1=C\C1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1)C(=O)N1CCOCC1,,CC(C)O,,C1CC[NH2+]CC1.CC(=O)[O-],,val
US20070032517A1,COC(=O)CC(=O)N(C)c1nc(-c2ccc(Cl)cc2Cl)c(-c2ccc(Cl)cc2)cc1C#N>>COC(=O)c1c(N)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2n(C)c1=O,,C1CCOC1,CO,N,,val
US20110166164A1,Clc1ncnc2scnc12.NCCc1ccc(Oc2cnccc2C(F)(F)F)cc1>>FC(F)(F)c1ccncc1Oc1ccc(CCNc2ncnc3scnc23)cc1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120046278A1,CSc1nc2c(N3CCN(C(=O)COc4ccc(Cl)cc4)CC3)nc(N)nc2s1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc2c(N3CCN(C(=O)COc4ccc(Cl)cc4)CC3)nc(N)nc2s1,,ClCCl,,,,val
US06365592B1,Cc1ccc(C(F)(F)C(=O)OC(C)(C)C)cc1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)C(F)(F)c1ccc(CBr)cc1,,CCCCCC,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20100234429A1,CC(=O)CCl.Sc1ccccc1>>CC(=O)CSc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05597848,COC(=O)CCCc1ccc(C(O)Cc2ccccc2)cc1.O=S(Cl)Cl>>COC(=O)CCCc1ccc(C(Cl)Cc2ccccc2)cc1,,c1ccccc1,,,,val
US20050080271A1,CC(C)C(N)C(=O)N(CCN(C)C)Cc1ccccc1.O=C=Nc1ccc(OC(F)(F)F)cc1>>CC(C)[C@H](NC(=O)Nc1ccc(OC(F)(F)F)cc1)C(=O)N(CCN(C)C)Cc1ccccc1,,ClCCl,,,,val
US20070232627A1,CC(C)c1ccc2c(Nc3cc(C(=O)Nc4ccc(C(F)(F)F)cc4)ccc3Oc3ccc(NC(=O)OC(C)(C)C)cc3)ncnc2n1>>CC(C)c1ccc2c(Nc3cc(C(=O)Nc4ccc(C(F)(F)F)cc4)ccc3Oc3ccc(N)cc3)ncnc2n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US05318966,CCCN1CC[C@@H]2c3c(O)cccc3CC[C@@H]21.CN(C)C(=O)Cl.Cl>>CN(C)C(=O)Oc1cccc2c1[C@H]1CCN[C@H]1CC2.Cl,CN(C)c1ccncc1,Cc1ccccc1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20160002251A1,CC1(C)OB(c2cc(C(F)(F)F)ccc2N)OC1(C)C.FC(F)(F)c1ccc(Br)cn1>>Nc1ccc(C(F)(F)F)cc1-c1ccc(C(F)(F)F)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20140005191A1,Cc1ccc(S(=O)(=O)Cl)cc1.OC[C@H]1O[C@@H]2SC(N3CCC3)=N[C@@H]2[C@@H](O)[C@@H]1O>>Cc1ccc(S(=O)(=O)OC[C@H]2O[C@@H]3SC(N4CCC4)=N[C@@H]3[C@@H](O)[C@@H]2O)cc1,,CN(C)C=O,,CCN(CC)CC,,val
US20050107364A1,CC1(CC2CC2)C(=O)C(C2=NS(=O)(=O)c3cc(N)ccc3N2)=C(O)c2ccccc21.CS(=O)(=O)Cl>>CC1(CC2CC2)C(=O)C(C2=NS(=O)(=O)c3cc(NS(C)(=O)=O)ccc3N2)=C(O)c2ccccc21,,ClCCl,,c1ccncc1,,val
US20060281772A1,CC(C)Oc1ccc(NC(=O)Oc2ccc([N+](=O)[O-])cc2)cc1.Clc1ccc2c(C3CCNCC3)ncnc2c1>>CC(C)Oc1ccc(NC(=O)N2CCC(c3ncnc4cc(Cl)ccc34)CC2)cc1,,CO,,CCN(C(C)C)C(C)C,,val
US20030013715A1,CC(C)(Cc1ccccc1Cl)[N+](=O)[O-]>>CC(C)(N)Cc1ccccc1Cl,[Ni],CCO,,,,val
US20050032786A1,COC(=O)c1ccccc1S.N#Cc1cccc(-c2cccs2)n1>>O=c1nc(-c2cccc(-c3cccs3)n2)sc2ccccc12,,Cc1ccccc1,,CCN(CC)CC,,val
US20070275968A1,COC(OC)N(C)C.NN.O=C(Cc1ccc(F)c(Br)c1)c1ccccn1>>Fc1ccc(-c2c[nH]nc2-c2ccccn2)cc1Br,,C1CCOC1,CCO,O,,val
US20160083370A1,Cc1ccc(S(=O)(=O)OCCCCc2c[nH]c3ccc(F)cc23)cc1.Cc1nc(N2CCNCC2)sc1C(N)=O>>Cc1nc(N2CCN(CCCCc3c[nH]c4ccc(F)cc34)CC2)sc1C(N)=O,,CC#N,,[I-].[K+],,val
US20140163012A1,CC(C)(C)OC(=O)N1CCc2oc3cc(-n4ccc(OCc5ccc(C(F)(F)F)nn5)cc4=O)ccc3c2C1>>O=c1cc(OCc2ccc(C(F)(F)F)nn2)ccn1-c1ccc2c3c(oc2c1)CCNC3,,CCOCC,CO,Cl,,val
US20120071512A1,CN1C(=O)Cc2c1ccc(Br)c2C1CC1.OB(O)c1cccnc1>>CN1C(=O)Cc2c1ccc(-c1cccnc1)c2C1CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20110183985A1,CC(=O)c1cc(Cl)c2cccnc2c1-c1cccc(F)c1.[NH4+]>>CC(N)c1cc(Cl)c2cccnc2c1-c1cccc(F)c1,,CC#N,CO,[BH3-]C#N.[Na+],,val
US20150119366A1,O=C(c1ccccc1)N(CCCCCCO)C1CCCCC1>>O=CCCCCCN(C(=O)c1ccccc1)C1CCCCC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20020103371A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.O=c1[nH]c2ccc(O)cc2c(=O)o1>>CC(C)(C)[Si](Oc1ccc2[nH]c(=O)oc(=O)c2c1)(c1ccccc1)c1ccccc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20010027197A1,NC(=O)c1nc(Cl)ccc1[N+](=O)[O-]>>NC(=O)c1ncccc1N,[Pd],CCOC(C)=O,CO,,,val
US20070208005A1,CC(C)(C)OC(=O)N1CCc2ccc(Cc3ccc(C(=O)O)nc3)cc2CC1.CC(N)=NO>>Cc1noc(-c2ccc(Cc3ccc4c(c3)CCN(C(=O)OC(C)(C)C)CC4)cn2)n1,,ClCCl,,,,val
US20110105461A1,C1CCNCC1.Cc1ccc(S(=O)(=O)OCC2COc3ccc(S(C)(=O)=O)cc3O2)cc1>>CS(=O)(=O)c1ccc2c(c1)OC(CN1CCCCC1)CO2,,CC#N,,,,val
US20130210844A1,CC(C)(C)N.Cc1nc(Cl)c2cccc([N+](=O)[O-])c2n1>>Cc1nc(NC(C)(C)C)c2cccc([N+](=O)[O-])c2n1,,c1ccncc1,,,,val
US20090137572A1,Cc1nc(C)c(/C=C/C(=O)N(C)C)s1.N=C(N)Nc1ccc(N2CCSCC2)cc1>>Cc1nc(C)c(-c2ccnc(Nc3ccc(N4CCSCC4)cc3)n2)s1,,CC#N,,,,val
US20130178478A1,CCOC(=O)c1nnc(Cl)cc1Cl.CCc1cccc(N)n1>>CCOC(=O)c1nnc(Cl)cc1Nc1cccc(CC)n1,,CC#N,,,,val
US20100204196A1,CC(C)CI.COc1cc(N2CCNCC2)ccc1[N+](=O)[O-]>>COc1cc(N2CCN(CC(C)C)CC2)ccc1[N+](=O)[O-],,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040097522A1,CC(N)C(F)(F)F.FCCCBr>>CC(NCCCF)C(F)(F)F,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050261303A1,O=C(O)c1ccc(C(F)(F)F)nc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=NCc1ccc(C(F)(F)F)nc1,,CCN(CC)CC,,CCOC(C)=O,,val
US20120208814A1,CC(=O)N1c2ccc(-c3ccc(CN(C)C(=O)OCc4ccccc4)cc3)cc2[C@H](Nc2ccc(F)cn2)C[C@@H]1C.Cl>>CNCc1ccc(-c2ccc3c(c2)[C@H](Nc2ccc(F)cn2)C[C@H](C)N3C(C)=O)cc1.Cl,[Pd],CCO,CO,,,val
US05596001,CSc1cc(C)nc(SC)c1N=C=O.Nc1cnc2ccc(Cl)cc2c1-c1ccccc1Cl>>CSc1cc(C)nc(SC)c1NC(=O)Nc1cc(-c2ccccc2Cl)c2cc(Cl)ccc2n1,,CCOC(C)=O,,CN(C)C=O,,val
US20090239911A1,NC1CCC(F)(F)CC1.O=C(Cl)CCCCl>>O=C(CCCCl)NC1CCC(F)(F)CC1,,ClCCl,,CCN(CC)CC,,val
US20080194582A1,CC(=O)Cl.NN.O=C(C=C(CCCOC1CCCCO1)c1ccccc1)c1cc(Br)ccc1F>>CC(=O)N1N=C(c2cc(Br)ccc2F)CC1(CCCO)c1ccccc1,,c1ccncc1,,O,,val
US05633270,CC(C)(C)OC(=O)[C@@H]1CS[C@H](c2ccccc2-c2ccccc2)N1C(=O)CNC(=O)Nc1cccc(CC(=O)OCc2ccccc2)c1>>CC(C)(C)OC(=O)[C@@H]1CS[C@H](c2ccccc2-c2ccccc2)N1C(=O)CNC(=O)Nc1cccc(CC(=O)O)c1,[Pd],,,O=C[O-].[NH4+],,val
US20040180934A1,COC(=O)CC1CCn2c1c(Sc1ccc(Cl)cc1)c1c(C(C)C)cc(S(C)(=O)=O)cc12>>CC(C)c1cc(S(C)(=O)=O)cc2c1c(Sc1ccc(Cl)cc1)c1n2CCC1CC(=O)O,,C1CCOC1,CO,CC(=O)O,[Li+].[OH-],val
US20080188528A1,COC(=O)c1cccn(CC(=O)N(c2ccccc2)c2ccccc2)c1=O>>O=C(O)c1cccn(CC(=O)N(c2ccccc2)c2ccccc2)c1=O,,CO,,[Na+].[OH-],,val
US20120010191A1,CC(=O)OCc1c(Br)cccc1Br.CC1(C)Cc2cc3n(c2C1)CCNC3=O>>CC(=O)OCc1c(Br)cccc1N1CCn2c(cc3c2CC(C)(C)C3)C1=O,[Cu]I,COCCOC,,,,val
US20040057904A1,Cc1ccc(S(=O)(=O)Cl)cc1.N[C@@H]1CCCC[C@H]1N>>Cc1ccc(S(=O)(=O)N[C@@H]2CCCC[C@H]2N)cc1,,ClCCl,,,,val
US20150344481A1,C1CCNC1.CS(=O)(=O)c1ccc2nc(-c3ccc(F)cc3)c(-c3ccc4nc(NC(=O)c5ccncc5)cn4n3)n2n1>>O=C(Nc1cn2nc(-c3c(-c4ccc(F)cc4)nc4ccc(N5CCCC5)nn34)ccc2n1)c1ccncc1,,CN1CCCC1=O,,,,val
US20040063645A1,N=C(N)n1cccn1.NCC(=O)Nc1ccc2oc(C(=O)Nc3ccc4[nH]c(C(=O)O)cc4c3)cc2c1>>N=C(N)NCC(=O)Nc1ccc2oc(C(=O)Nc3ccc4[nH]c(C(=O)O)cc4c3)cc2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20040053973A1,Cc1cccc(C(=O)C(Br)c2ccnc(F)c2)c1.NC(=S)CCc1ccccc1>>CCc1nc(-c2cccc(C)c2)c(-c2ccnc(F)c2)s1,,CN(C)C=O,,Br,O=C([O-])O.[Na+],val
US20040102484A1,COc1ccc(C(=O)O)cc1.O=S(=O)(O)Cl>>COc1ccc(C(=O)O)cc1S(=O)(=O)Cl,,O,,,,val
US20110311474A1,CCOP(C)(=O)OCC.COC(=O)C12CCC(NS(=O)(=O)C3CC3)(CC1)CC2>>CCOP(=O)(CC12CCC(NS(=O)(=O)C3CC3)(CC1)CC2)OCC,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20090149454A1,CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.O=C([O-])c1cc(CO)on1>>CCOC(=O)c1cc(CO[Si](C)(C)C(C)(C)C)on1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20140274951A1,O=C(CCCC[Si]1(O)CCCCC1)OCc1ccccc1>>O=C(O)CCCC[Si]1(O)CCCCC1,[Pd],CCO,,,,val
US20090118275A1,CC(C)(O)c1nc2c(N3CCOCC3)nc(Cl)nc2s1.CI>>COC(C)(C)c1nc2c(N3CCOCC3)nc(Cl)nc2s1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20130172320A1,Cc1ccc(CCC2(C)CN(C)CCC2=O)cn1.Cc1ccc(NN)cc1>>Cc1ccc2[nH]c3c(c2c1)CN(C)CC3(C)CCc1ccc(C)nc1,,Cl,,,,val
US04996215,C=O.CS(=O)(=O)Nc1ccc(C(=O)C2CCNCC2)cc1.Cc1ccco1>>Cc1ccc(CN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)o1,,CC(=O)O,O,[Na+].[OH-],,val
US20050032873A1,NC(=O)c1cccc2c1CC(NCCCc1c[nH]c3ccc(F)cc13)CO2.O=CC1CC1>>NC(=O)c1cccc2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)CC1CC1)CO2,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US05530002,ClCCNCCCl.Nc1cccc2ccc(OCC3CC3)cc12>>c1cc(N2CCNCC2)c2cc(OCC3CC3)ccc2c1,,CCCCO,,Cl,[I-].[K+],val
US20040199024A1,CC(C)(C)Oc1nc(Cl)cc2ccccc12>>O=c1[nH]c(Cl)cc2ccccc12,,O,O=CO,,,val
US04898872,Cc1cc(-n2c(C)nc3ccccc32)ccc1[N+](=O)[O-]>>Cc1cc(-n2c(C)nc3ccccc32)ccc1N,,CCO,,[Na+].[OH-],,val
US20120028961A1,CS(=O)(=O)Cl.Cc1cccc([C@@H](C)O)n1>>Cc1cccc([C@@H](C)OS(C)(=O)=O)n1,,ClCCl,,CCN(CC)CC,,val
US20140051672A1,Oc1cc(-n2cccn2)ccc1-c1ccc(C2=CCNCC2)nn1>>Oc1cc(-n2cccn2)ccc1-c1ccc(C2CCNCC2)nn1,[Pd],CO,,,,val
US20090143372A1,CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(Br)cc23)CC1.OB(O)c1ccc(CNCC2CC2)s1>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccc(CNCC5CC5)s4)cc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20120214762A1,Cc1cc(Cl)nc(N)n1.Cc1n[nH]c2cc(Br)ccc12>>Cc1cc(-n2nc(C)c3ccc(Br)cc32)nc(N)n1,,CC#N,CN(C)C=O,[H-].[Na+],,val
US20130096030A1,COCCOCCOCCSC1=C(SCCOCCOCCOC)SC(=C2Sc3cn(S(=O)(=O)c4ccc(C)cc4)cc3S2)S1>>COCCOCCOCCSC1=C(SCCOCCOCCOC)SC(=C2Sc3c[nH]cc3S2)S1,,C1CCOC1,,CO,O,val
US20110245242A1,CCC1CC(C)C(=O)N1.Nc1cccc(I)c1>>CCC1CC(C)C(=O)N1c1cccc(N)c1,[Cu]I,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110183997A1,CC(C)[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O.Cc1cc2c(cn1)cc(-c1cc(N/C(N)=N/O)ccc1C)c(=O)n2C>>Cc1cc2c(cn1)cc(-c1cc(Nc3noc([C@H](O)C(C)C)n3)ccc1C)c(=O)n2C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030100770A1,O=C(OCc1ccccc1)[C@H]1CCCN1C(=O)COc1ccccc1OCC(=O)N1CCC[C@@H]1C(=O)OCc1ccccc1>>O=C(O)[C@H]1CCCN1C(=O)COc1ccccc1OCC(=O)N1CCC[C@@H]1C(=O)O,[Pd],CCO,,,,val
US20060211734A1,C[C@@H]1CN(Cc2ccccc2)CC[C@@H]1Oc1cccc(N)c1.O=C(Cl)c1ccc(F)cc1Cl>>CC1CN(Cc2ccccc2)CCC1Oc1cccc(NC(=O)c2ccc(F)cc2Cl)c1,,CO,,C1COCCO1,,val
US20160145218A1,COC(=O)c1sc(C)c(C)c1C=O.NN>>Cc1sc2c(=O)[nH]ncc2c1C,,CCO,,O,,val
US20090247514A1,O=C(O)c1ccc2c(c1)CC1(C2)C(=O)Nc2ccccc21.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Nc1ccc2c(c1)CC1(C2)C(=O)Nc2ccccc21,,CC(C)(C)O,,CCN(CC)CC,,val
US20150368267A1,CC(C)(CN)CNC(=O)c1ccc(Nc2nc(NCc3ccc(O)cc3)nc(OCC(F)(F)F)n2)cc1.COC(=O)C(=O)Cl>>COC(=O)C(=O)NCC(C)(C)CNC(=O)c1ccc(Nc2nc(NCc3ccc(O)cc3)nc(OCC(F)(F)F)n2)cc1,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US04789465,NS(=O)(=O)c1ncccc1Cl.OO>>NS(=O)(=O)c1c(Cl)ccc[n+]1[O-],,O=C(O)C(F)(F)F,,,,val
US20090062297A1,COC(=O)c1ccc(C(C)(O)C(=O)OC)cc1>>COC(=O)c1ccc(C(C)(O)C(=O)O)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20090298836A1,CC(C)(C)OC(=O)N[C@H](CNc1nnc(-c2cc3c(Cl)cncc3s2)s1)Cc1cccc(C(F)(F)F)c1>>N[C@H](CNc1nnc(-c2cc3c(Cl)cncc3s2)s1)Cc1cccc(C(F)(F)F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050026916A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1=N[C@@H](c2ccccc2)[C@@H](c2ccccc2)N1>>CC1=N[C@@H](c2ccccc2)[C@@H](c2ccccc2)N1C(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20090221586A1,CC(=O)Cl.COc1ccc(-c2nc(CCC(=O)c3ccccc3O)co2)cc1OC(C)C>>COc1ccc(-c2nc(CCC(=O)c3ccccc3OC(C)=O)co2)cc1OC(C)C,,ClCCl,,CCN(CC)CC,O,val
US20070293516A1,CCOc1cc(C(OC)=C(C#N)C#N)ccc1OC.NNCCO>>CCOc1cc(-c2nn(CCO)c(N)c2C#N)ccc1OC,,CCO,,CCN(CC)CC,O,val
US20130143870A1,CC(=O)OC(C)=O.NC1CC(Cc2ccccc2)N(C(=O)OCc2ccccc2)CCC1O>>CC(=O)NC1CCN(C(=O)OCc2ccccc2)CCC1O,,ClCCl,,O=C([O-])O.[Na+],,val
US20140163012A1,CN1CCCc2oc3cc(-n4ccc(OCc5cccc(C(F)(F)F)n5)cc4=O)ccc3c2C1.Cl>>CN1CCCc2oc3cc(-n4ccc(OCc5cccc(C(F)(F)F)n5)cc4=O)ccc3c2C1.Cl,,CO,,CCOCC,,val
US20030069297A1,CCN(CC)CCNC(=O)c1c(C)[nH]c(C=O)c1C.O=C1Cc2c(cccc2-c2ccc(Cl)cc2)N1>>CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3cccc(-c4ccc(Cl)cc4)c32)c1C,C1CCNCC1,CCO,,,,val
US20100190778A1,COc1ccc2c(c1OC)S(=O)(=O)NN=C2C>>COc1ccc2c(c1OC)S(=O)(=O)NNC2C,O=[Pt]=O,,,,,val
US20130336920A1,CC(=O)Cl.O=C(NCc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(N3CCCCC3)ccc2NC(=O)c2cccc(CN3CCCNCC3)n2)c1>>CC(=O)N1CCCN(Cc2cccc(C(=O)Nc3ccc(N4CCCCC4)cc3-c3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccn3)n2)CC1,,ClCCl,,CCN(CC)CC,,val
US20020120148A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccc2c(c1)CC(NC[C@H](O)COc1ccccc1)CCC2>>COC(=O)c1ccc2c(c1)CC(N(C[C@H](O)COc1ccccc1)C(=O)OC(C)(C)C)CCC2,,C1CCOC1,,Cl,,val
US20070060607A1,CCOC(=O)c1cnc(Cl)c2c(CBr)csc12.Cc1ccc(NC(=O)c2cccc(Cl)c2)cc1O>>CCOC(=O)c1cnc(Cl)c2c(COc3cc(NC(=O)c4cccc(Cl)c4)ccc3C)csc12,,C1CCOC1,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050020619A1,CC1(C)OB(c2ccc(N)cc2)OC1(C)C.Cn1c(C(=O)O)cc2ccccc21>>Cn1c(C(=O)Nc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)cc2ccccc21,CN(C)C=O,ClCCl,,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20090163524A1,N[C@@H](CC(=O)O)c1ccc(Cl)cc1>>N[C@@H](CCO)c1ccc(Cl)cc1,,C1CCOC1,,CO,,val
US20140094450A1,COC(=O)c1ccc(NC2CCCCC2C(F)(F)F)c(NC(=O)Cc2cccs2)c1>>O=C(O)c1ccc2c(c1)nc(Cc1cccs1)n2C1CCCCC1C(F)(F)F,,C1COCCO1,,Cl,O,val
US04826860,Nc1ccccc1.S=C=NCc1ccccc1>>S=C(NCc1ccccc1)Nc1ccccc1,,Cc1ccccc1,,,,val
US20100249142A1,Nc1ccccc1F.O=c1c2nccn2c(=O)c2nccn12>>O=C(Nc1ccccc1F)c1ncc[nH]1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20040224939A1,O=C1CCCc2ccc(Br)cc2C1.O=C1NCC(CO)O1>>O=C1CCCc2ccc(N3CC(CO)OC3=O)cc2C1,[Cu]I,CN(C)C=O,,N[C@@H]1CCCC[C@H]1N,O=C([O-])[O-].[K+].[K+],val
US20080319019A1,CCCS(=O)(=O)Cl.O=C(NN1CCCCC1)c1nc(-c2ccc(Cl)cc2Cl)n(-c2ccc(O)cc2)c1CO>>CCCS(=O)(=O)Oc1ccc(-n2c(-c3ccc(Cl)cc3Cl)nc(C(=O)NN3CCCCC3)c2CO)cc1,,ClCCl,,CCN(CC)CC,,val
US20100004292A1,COC(=O)c1cnc(C)nc1N.O=C(Cl)c1ccc(Cl)s1>>COC(=O)c1cnc(C)nc1NC(=O)c1ccc(Cl)s1,,ClCCl,,,,val
US04024187,CC(=O)c1cccc([N+](=O)[O-])c1>>CC(O)c1cccc(N)c1,[Ni],O,,[H][H],,val
US20090208449A1,CCOC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)oc2cc(N3CCNS3(=O)=O)c(C3CC3)cc12.CI>>CCOC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)oc2cc(N3CCN(C)S3(=O)=O)c(C3CC3)cc12,,CN(C)C=O,,[H-].[Na+],,val
US20070054942A1,CCNC(=O)c1ccc(C)c(B2OC(C)(C)C(C)(C)O2)c1.Fc1cc2c(-c3ccc(Cl)nc3)n[nH]c2cc1Br>>CCNC(=O)c1ccc(C)c(-c2cc3[nH]nc(-c4ccc(Cl)nc4)c3cc2F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(C)O,,O=C([O-])O.[Na+],,val
US06093732,CC(C)O.O=C(NCc1ccc(Cl)cc1)c1cnc2c(F)c(F)c(F)cc2c1O>>CC(C)Oc1c(F)cc2c(O)c(C(=O)NCc3ccc(Cl)cc3)cnc2c1F,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20070043064A1,C#CCN(c1cccc(C(=O)C=CN(C)C)c1)S(C)(=O)=O.Nc1[nH]ncc1[N+](=O)[O-]>>C#CCN(c1cccc(-c2ccnc3c([N+](=O)[O-])cnn23)c1)S(C)(=O)=O,,CC(=O)O,,CCOC(C)=O,,val
US20070249591A1,COC(=O)c1nc(-c2ccc(NC(=O)OC(C)(C)C)cc2)cn1C>>Cn1cc(-c2ccc(NC(=O)OC(C)(C)C)cc2)nc1C(=O)O,,CO,,[K+].[OH-],,val
US20130184286A1,O=S(Cl)Cl.O=c1c2ccccc2ncn1CCO>>O=c1c2ccccc2ncn1CCCl,,O,,,,val
US20030236288A1,CC1(C)CC(Oc2ccc(N)cc2)CC(C)(C)C1.Cl.O=N[O-]>>CC1(C)CC(Oc2ccc(NN)cc2)CC(C)(C)C1.Cl,,Cl,O,Cl[Sn]Cl,,val
US20160145247A1,C[C@@H](NC(=O)OC(C)(C)C)c1cccc(-c2cc(COc3ccccc3CC(=O)OC(C)(C)C)cc(OCC3(C)CC3)c2)c1F>>C[C@@H](N)c1cccc(-c2cc(COc3ccccc3CC(=O)O)cc(OCC3(C)CC3)c2)c1F,,C1COCCO1,ClCCl,Cl,,val
US20130324579A1,BrCCOc1ccccc1.O=[N+]([O-])c1cn[nH]c1>>O=[N+]([O-])c1cnn(CCOc2ccccc2)c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120295924A1,CC(=O)NC(=N)N.O=C(CBr)c1cccc(OC(F)(F)F)c1>>CC(=O)Nc1nc(-c2cccc(OC(F)(F)F)c2)c[nH]1,,CC#N,,,,val
US20130116243A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)N(CS(C)(=O)=O)C(=O)CO4)cc2)CCC1>>CS(=O)(=O)CN1C(=O)COc2nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)cc21,,O=C(O)C(F)(F)F,,,,val
US20040167158A1,CC(C)I.CCN(CC)CCc1ccc2cc[nH]c2c1>>CCN(CC)CCc1ccc2ccn(C(C)C)c2c1,,CN(C)C=O,Cc1ccccc1,[H-].[Na+],O=C([O-])[O-].[K+].[K+],val
US20090275537A1,CC1(C)OC[C@@H](CO)O1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC1(C)OCC(COS(=O)(=O)C(F)(F)F)O1,,ClCCl,,Cc1cccc(C)n1,,val
US20040077618A1,CC1CCCC(CC(=O)O)C1.NCC(N)=O>>CC1CCCC(CC(=O)NCC(N)=O)C1,,CCOC(C)=O,,Cl,O=C(n1ccnc1)n1ccnc1,val
US20060094719A1,C1CCNC1.ClCCCOc1ccc2c(c1)CCC(CN1CCCC1)C2>>Cl.c1cc2c(cc1OCCCN1CCCC1)CCC(CN1CCCC1)C2,,CCC(C)=O,,[I-].[K+],,val
US20060199829A1,COC(=O)Cl.c1ccc(CN2CCc3c(oc4ccccc34)C2)cc1>>COC(=O)N1CCc2c(oc3ccccc23)C1,,CC(Cl)Cl,,,,val
US20040224992A1,COc1ccc(F)cc1C(C)(C)CC(O)(C(=O)Nc1ccccc1)C(F)(F)F>>CC(C)(CC(O)(C(=O)Nc1ccccc1)C(F)(F)F)c1cc(F)ccc1O,,ClCCl,,BrB(Br)Br,,val
US20140336106A1,COc1ccc([C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)CN2CCOCC2)C(=O)OCc2ccccc2)cc1>>COc1ccc([C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)CN2CCOCC2)C(=O)O)cc1,[Pd],C1CCOC1,,,,val
US04444773,CCOC(=O)C(OC(C)=O)C(C)=O.Nc1ncc(Cl)s1>>Cc1nc2sc(Cl)cn2c(=O)c1O,,CC(=O)N(C)C,,Cl,,val
US20090233919A1,COc1ccc(-c2nc3c(s2)C(=O)N(c2ccc(OC(=O)C(C)(C)C)c(OC)c2)CC3)cc1>>COc1ccc(-c2nc3c(s2)C(=O)N(c2ccc(O)c(OC)c2)CC3)cc1,,CCO,,C[O-].[Na+],,val
US20130079313A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCc1ccc(OC)c([N+](=O)[O-])c1>>COc1ccc(CN(C)C(=O)OC(C)(C)C)cc1[N+](=O)[O-],CN(C)c1ccncc1,ClCCl,,,,val
US20150031668A1,CN.Cc1cc(C(=O)N[C@]2(c3ccc(OC(F)(F)F)c(F)c3)CCOc3cccnc32)ccc1C(=O)O>>CNC(=O)c1ccc(C(=O)N[C@]2(c3ccc(OC(F)(F)F)c(F)c3)CCOc3cccnc32)cc1C,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150299204A1,CC(C)(C)OC(=O)N1CCNCC1.CCCCc1nc(N)c2c(n1)c(CCCC=O)cn2COCc1ccccc1>>CCCCc1nc(N)c2c(n1)c(CCCCN1CCN(C(=O)OC(C)(C)C)CC1)cn2COCc1ccccc1,,ClCCl,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US06319702B1,CC[Si](CC)(CC)c1cccc(C[C@H]2C(=O)O[C@H](c3ccccc3)[C@H](c3ccccc3)N2C(=O)OC(C)(C)C)c1>>C[Si](C)(C)c1cccc(C[C@@H]2N[C@@H](c3ccccc3)[C@@H](c3ccccc3)OC2=O)c1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20160052939A1,CC(C)(C)OC(=O)N1C[C@H]2C[C@@H](Nc3ncc(C(F)(F)F)cc3F)[C@@H]1C2>>Fc1cc(C(F)(F)F)cnc1N[C@@H]1C[C@@H]2CN[C@H]1C2,,C1COCCO1,CCOC(C)=O,Cl,,val
US20120295884A1,CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1CO.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1COS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20070032537A1,CCOC(=O)c1cc(C=O)[nH]n1.NCc1ccccc1>>CCOC(=O)c1cc(CNCc2ccccc2)[nH]n1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100143830A1,O=C(Cl)C12CC3CC(CC(C3)C1)C2.O=S(=O)([O-])CCCO.c1ccc([S+](c2ccccc2)c2ccccc2)cc1>>O=C(OCCCS(=O)(=O)[O-])C12CC3CC(CC(C3)C1)C2.c1ccc([S+](c2ccccc2)c2ccccc2)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20120034250A1,C[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1n1ccc2cnc3c(c(Br)cn3COCC[Si](C)(C)C)c21.N#C[Zn]C#N>>C[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1n1ccc2cnc3c(c(C#N)cn3COCC[Si](C)(C)C)c21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])O.[Na+],,val
US04992544,CCC(O)(CC(=O)OC(C)C)C(=O)OC(C)C>>CCC(O)(CC(=O)O)C(=O)OC,,C1COCCO1,,[K+].[OH-],,val
US20090192162A1,CCOC(=O)COc1ccc(Sc2cc(C#CCN3CCOCC3)cc(Oc3ncccc3C(F)(F)F)c2)cc1C>>Cc1cc(Sc2cc(C#CCN3CCOCC3)cc(Oc3ncccc3C(F)(F)F)c2)ccc1OCC(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20080146625A1,Cn1ccc(N)n1.O=C(O)/C(=N/OC1CCCC1)c1ccc(Cl)c(Cl)c1>>Cn1ccc(NC(=O)/C(=N/OC2CCCC2)c2ccc(Cl)c(Cl)c2)n1,,ClC(Cl)Cl,ClCCl,CCN(C(C)C)C(C)C,,val
US20140378462A1,COC(=O)c1c(NC(=O)C(C)(C)C)ccc2c1OCC(=O)C2.NN.O=CC(=O)O>>COC(=O)c1c(NC(=O)C(C)(C)C)ccc2c1OCc1nnc(O)cc1-2,,C1CCOC1,CCO,O,O,val
US20050004370A1,CCCc1[nH]cnc1C(=O)OCC.Cl>>CCCc1[nH]cnc1C(=O)O.Cl,,O,,,,val
US20070232645A1,CC(=O)Nc1ccc(S)cc1.O=[N+]([O-])c1ccc(Cl)cc1Cl>>CC(=O)Nc1ccc(Sc2cc(Cl)ccc2[N+](=O)[O-])cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04550103,c1ccc(CN2CCC(CNC3CC3)C2)cc1>>C1CC(CNC2CC2)CN1,[Pd],CO,,[H][H],,val
US20070088018A1,CN(C)C(=O)Cl.O=C(c1ccc(S(=O)(=O)n2cc(-c3ccccc3)c3ccccc32)cc1)N1CC(O)C1>>CN(C)C(=O)OC1CN(C(=O)c2ccc(S(=O)(=O)n3cc(-c4ccccc4)c4ccccc43)cc2)C1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20040254205A1,COc1cc2ncnc3c2c(c1OC)CC(CI)N3c1ccc(Br)cc1F>>COc1cc2ncnc3c2c(c1OC)C=C(C)N3c1ccc(Br)cc1F,,Cc1ccccc1,ClC(Cl)Cl,C1CCC2=NCCCN2CC1,,val
US20080255352A1,O=C(O)[C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1.O=C1CCN(C2CCNCC2)C(=O)N1>>O=C1CCN(C2CCN(C(=O)[C@H](O)CS(=O)(=O)c3ccc4cc(Cl)ccc4c3)CC2)C(=O)N1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US04629495,CCN.N#Cc1cnn(-c2ccc(C(F)(F)F)cc2Cl)c1NCC(=O)Cl>>CCNC(=O)CNc1c(C#N)cnn1-c1ccc(C(F)(F)F)cc1Cl,,CCC(C)=O,,,,val
US20060074075A1,BrCc1ccccc1.CC(C)(C)c1ccc(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O>>CC(C)(C)c1ccc(NC(=O)c2cnc3ccccc3c2OCc2ccccc2)cc1O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04383113,CC(C)OC(=O)c1ccccc1S(=O)(=O)N=C=O.COc1nc(N)nc(OC)n1>>COc1nc(NC(=O)NS(=O)(=O)c2ccccc2C(=O)OC(C)C)nc(OC)n1,,ClCCl,,,,val
US20120309738A1,CC(C)(C)C(=O)NCc1ccc(Cl)c([N+](=O)[O-])c1>>CC(C)(C)C(=O)NCc1ccc(Cl)c(N)c1,[Ni],C1CCOC1,,,,val
US20140018313A1,COC[C@H]1C[C@@H](c2ncc(-c3cc4c5c(c3)OCc3cc(-c6cnc([C@@H]7C[C@H](C)CN7C(=O)[C@H](NC(=O)OC)c7ccccc7)[nH]6)cc(c3-5)OC4)[nH]2)N(C(=O)OC(C)(C)C)C1>>COC[C@@H]1CN[C@H](c2ncc(-c3cc4c5c(c3)OCc3cc(-c6cnc([C@@H]7C[C@H](C)CN7C(=O)[C@H](NC(=O)OC)c7ccccc7)[nH]6)cc(c3-5)OC4)[nH]2)C1,,CCO,,Cl,,val
US20100305093A1,CCCC[Sn](CCCC)(CCCC)c1ccc(C(=O)OC)c(C)c1.II>>COC(=O)c1ccc(I)cc1C,,ClC(Cl)Cl,,,,val
US20140179673A1,C[C@H](N)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1.Nc1ncnc(Cl)c1I>>C[C@H](Nc1ncnc(N)c1I)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1,,CC(C)O,,CCN(C(C)C)C(C)C,O,val
US20160244429A1,Cc1ccc(S(=O)(=O)OCCCc2c[nH]c3ccc(F)cc23)cc1.O=C1COCCN1c1ccc(N2CCNCC2)cc1>>O=C1COCCN1c1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)cc1,,CC#N,,[I-].[K+],,val
US20110251190A1,COc1nc(-c2cccnc2)cc2c1Oc1ccc(-c3cccnc3)cc1[C@@]21COC(N)=N1>>NC1=N[C@@]2(CO1)c1cc(-c3cccnc3)ccc1Oc1c2cc(-c2cccnc2)[nH]c1=O,,ClCCl,,BrB(Br)Br,,val
US20090247567A1,COC(=O)c1ccc2c(c1)OCCc1cc(C(=O)N(C)c3ccc(C(=O)N(C)C)cc3Cl)sc1-2>>CN(C)C(=O)c1ccc(N(C)C(=O)c2cc3c(s2)-c2ccc(C(=O)O)cc2OCC3)c(Cl)c1,,C1CCOC1,O,[Li]O,,val
US20140094459A1,CCN(C(=O)OC(C)(C)C)C(C)(C)C=O.N#CCC(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21>>CCN(C(=O)OC(C)(C)C)C(C)(C)C=C(C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21,CC(=O)O,C1COCCO1,,C1CCNCC1,,val
US20130079321A1,C=O.CO.Cn1ncc([N+](=O)[O-])c1N1CCC(N)CC(F)(F)C1>>CN(C)C1CCN(c2c([N+](=O)[O-])cnn2C)CC(F)(F)C1,,C1CCOC1,CO,[BH3-]C#N.[Na+],,val
US20030060473A1,CCOC(=O)Cl.O=C(NOC1CCCCO1)[C@H]1CNCCN1S(=O)(=O)c1ccc(-c2ccc(F)cc2)s1>>CCOC(=O)N1CCN(S(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)[C@@H](C(=O)NOC2CCCCO2)C1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US04873262,CCCCS(=O)(=O)Cl.CCCN(CCC)C1CCc2cccc(OCCN)c2C1>>CCCCS(=O)(=O)NCCOc1cccc2c1CC(N(CCC)CCC)CC2,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20060058259A1,CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)OCC(O)CBr.CCCCCCCCCCCCCCCCCC(=O)Cl>>CCCCCCCCCCCCCCCCCC(=O)OC(CBr)COC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C,,ClCCl,,c1ccncc1,O=C([O-])O.[Na+],val
US05834499,CCOP(=S)([S-])OCC.N#CCN1C(=O)c2ccccc2C1=O>>NC(=S)CN1C(=O)c2ccccc2C1=O,,CCOC(C)=O,Cl,,,val
US20130331379A1,Nc1cc(Cl)ccc1O.S=C(Cl)Cl>>Sc1nc2cc(Cl)ccc2o1,,CO,O,,,val
US04721711,N#CCCCBr.Nc1nnc(-c2ccccc2)cc1-c1ccccc1>>N#CCCCN1[NH2+]C(c2ccccc2)=CC(c2ccccc2)=C1N.[Br-],,CN(C)C=O,,,,val
US20090093472A1,CN(C)C=C(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)OC(C)(C)C.CNN>>Cn1cc(Cc2ccc(Cl)cc2)c([C@H]2CCCN2C(=O)OC(C)(C)C)n1,,CCO,,,,val
US20070249620A1,COC(C)(C)OC.O=[N+]([O-])c1ccc(OCC(O)CO)cc1C(F)(F)F>>CC1(C)OCC(COc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)O1,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120040948A1,Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)C(Cc2ccccc2)C(NCC(C)(C)CCl)C3)c1>>Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)C(Cc2ccccc2)C(N2CC(C)(C)C2)C3)c1,,CC#N,ClCCl,O=C([O-])O.[Na+],,val
US20050288340A1,CC(C)(C)c1ccccc1O.CCc1ccc(S(=O)(=O)NCCO)cc1C(=O)OC>>CCc1ccc(S(=O)(=O)NCCOc2ccc(C(C)(C)C)cc2)cc1C(=O)OC,,C1CCOC1,CCOC(C)=O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150376130A1,CCOC(=O)c1cc(F)cnc1Nc1ccc(C2CCCC2)nc1>>O=C(O)c1cc(F)cnc1Nc1ccc(C2CCCC2)nc1,,C1CCOC1,O,[Li+].[OH-],,val
US04670448,CN(C)Cc1cccc(OCCCNc2nc(CN)nn2C)c1.CS(=O)(=O)Cl>>CN(C)Cc1cccc(OCCCNc2nc(CNS(C)(=O)=O)nn2C)c1,,c1ccncc1,,,,val
US20070027182A1,COc1cccc(C23CCN(C)CC2(C)CCC(N)C3)c1.O=C1NC(=O)c2ccccc21>>COc1cccc(C23CCCCC2(C)C(N)NCC3)c1.O=C1NC(=O)c2ccccc21,,ClCCCl,,CC(Cl)OC(=O)Cl,,val
US20050222139A1,CC(C)(C)[Si](C)(C)Cl.O=C(NCCO)C1CNc2ccccc2O1>>CC(C)(C)[Si](C)(C)OCCC1(C(N)=O)CNc2ccccc2O1,,CCOC(C)=O,,CN(C)C=O,c1c[nH]cn1,val
US20120189547A1,CN1CC(=O)Nc2ccc(O)cc2C1=O.Cc1ccc(S(=O)(=O)OCCF)cc1>>CN1CC(=O)Nc2ccc(OCCF)cc2C1=O,,CN(C)C=O,CO,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],val
US20150376136A1,O=C(O)C1(c2ccccc2)CCC1>>O=C(O)C1(C2CCCCC2)CCC1,[Rh],CC(=O)O,,,,val
US20030161792A1,CCCCCCCCCCCCCC(=O)O.c1ccc(COCc2ccccc2)cc1>>CCCCCCCCCCCCCC(=O)OCc1ccccc1,,O,,OO,,val
US05580883,CC(Br)C(C)Br.CC(C)(C)OC(=O)N1CCC(COc2ccc(N)cc2)CC1.CN(C)C=O>>CC(C)(C)OC(=O)N1CCC(COc2ccc(N3CCCC3)cc2)CC1,,O,,O=C([O-])[O-].[K+].[K+],,val
US04794186,CCOC(=O)/C(=N\OC1CCNC1=O)c1csc(NC(C)=O)n1>>CC(=O)Nc1nc(/C(=N/OC2CCNC2=O)C(=O)O)cs1,,CO,,[Na+].[OH-],,val
US20090221555A1,Clc1ncc(Cl)c(Cl)n1.Nc1cccc(N2CCOCC2)c1>>Clc1ncc(Cl)c(Nc2cccc(N3CCOCC3)c2)n1,,C1CCOC1,ClCCl,O,O=C([O-])[O-].[K+].[K+],val
US05744478,CNC1C=CCC2CNCC21.Cc1csc2c(C(=O)O)c(=O)c3cc(F)c(F)c(F)c3n12>>CNC1C=CCC2CN(c3c(F)cc4c(=O)c(C(=O)O)c5scc(C)n5c4c3F)CC21,,CS(C)=O,,,,val
US20080139595A1,Nc1cc(F)c(Oc2ccnc3[nH]ccc23)c(F)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1cc(F)c(Oc2ccnc3[nH]ccc23)c(F)c1)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20120122780A1,CCOC(=O)CSc1snc(C)c1-c1cccc2ccccc12>>Cc1nsc(SCC(=O)O)c1-c1cccc2ccccc12,,CO,,[Na+].[OH-],,val
US20040259910A1,CCOC(=O)c1cnc(Cc2cccc(OC(C)C)c2)c2cc(OC)c(OC)cc12.O=[Se]=O>>CCOC(=O)c1cnc(C(=O)c2cccc(OC(C)C)c2)c2cc(OC)c(OC)cc12,,CCOC(C)=O,,,,val
US20110034507A1,COC(=O)c1cccc(C(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)c1cccc(C(=O)O)c1,,C1COCCO1,,[Li+].[OH-],,val
US05126362,Cc1cc(C(=O)O)n(C2CCC2)n1.O=S(Cl)Cl>>Cc1cc(C(=O)Cl)n(C2CCC2)n1,,c1ccccc1,,,,val
US20110207731A1,C[Si](C)(C)CCOCn1nc(SCc2ccccc2)c2cc(C3OCCO3)ccc21>>O=Cc1ccc2[nH]nc(SCc3ccccc3)c2c1,,CCO,,Cl,,val
US20140349972A1,CCOP(C)(=O)c1cccc([C@@H](N[S@@](=O)C(C)(C)C)c2ccccc2)c1>>CCOP(C)(=O)c1cccc([C@@H](N)c2ccccc2)c1,,C1COCCO1,Cl,,,val
US20150203515A1,COC(=O)C12CCC(NCc3ccc4cc(O[Si](C)(C)C(C)(C)C)ccc4n3)(CC1)CC2>>COC(=O)C12CCC(NCc3ccc4cc(O)ccc4n3)(CC1)CC2,,CO,,Cl,O=C([O-])O.[Na+],val
US20040167160A1,CC(=O)c1cc2c(-c3cc(C(C)(C)C)cc(C(C)(C)C)c3O)cccc2s1.FC(F)CBr>>CC(=O)c1cc2c(-c3cc(C(C)(C)C)cc(C(C)(C)C)c3OCC(F)F)cccc2s1,,CN(C)C=O,,[Cs+].[F-],,val
US20100022537A1,CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(SC)=NC1c1ccc(C#N)cc1>>COC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(SC)=NC1c1ccc(C#N)cc1,,CO,,C[O-].[Na+],,val
US06166064,CC(=O)c1cccc(Br)c1.C[Mg]Br>>CC(C)(O)c1cccc(Br)c1,,CCOCC,,Cl,O,val
US04155872,CCCCCCCCCCCCN=Cc1ccccc1>>CCCCCCCCCCCCNCc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060014797A1,CC(=O)OC(C)=O.CN(C)CCc1sc2ccccc2c1Br>>CC(=O)c1c(CCN(C)C)sc2ccccc12,,Cc1ccccc1,,CN(C)CCN(C)C,[Li]CCCC,val
US05534529,Br[Mg]CCCC1CCCCC1.O=CCOCc1ccccc1>>OC(CCCC1CCCCC1)COCc1ccccc1,,CCOCC,,[Cl-].[NH4+],,val
US20120225854A1,CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)CC2COCc2ccccc2)cc1)C(F)(F)F>>CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)CC2C=O)cc1)C(F)(F)F,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20150299163A1,CNC(=O)CCCCC[C@H](NC(=O)OCc1ccccc1)c1ncc(-c2ccc3cc(OC)ccc3c2)[nH]1>>CNC(=O)CCCCC[C@H](N)c1ncc(-c2ccc3cc(OC)ccc3c2)[nH]1,[Pd],CCOC(C)=O,CO,,,val
US03937840,CCOc1ccccc1N.Cc1ccccc1C(=O)Br>>CCOc1ccccc1NC(=O)c1ccccc1C,,CC(C)=O,,O=C([O-])O.[Na+],,val
US20070244118A1,O=C(O)C#CS(=O)(=O)c1ccc2cc(Cl)ccc2c1.O=C1CCCN1C1CCNCC1>>O=C(CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCCC2=O)CC1,,CCN(CC)CC,CN(C)C=O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US04468247,COc1cccc(OC)c1.FC(F)(F)c1ccc(Cl)c(Cl)c1>>c1ccc(OCOc2ccccc2)cc1,[Cu],,,CS(C)=O,[H-].[Na+],val
US05902813,CN(C)c1ncc(-c2cccc(Nc3ccc(-n4cccc4)cc3[N+](=O)[O-])c2)cn1>>CN(C)c1ncc(-c2cccc(Nc3ccc(-n4cccc4)cc3N)c2)cn1,[Pd],CCO,,[H][H],,val
US03948816,CCCCCCC=CC(=O)OC.S>>CCCCCCC(S)CC(=O)OC,,CO,,[Na],C[O-].[Na+],val
US20050131019A1,CNC.O=C(O)c1ccc(O)c(Cl)c1>>CN(C)C(=O)c1ccc(O)c(Cl)c1,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20090227570A1,CC(C)(C)OC(=O)N1CCC(NC(=O)Nc2ccc3nc(N[C@@H]4CCc5ccccc54)ccc3c2)CC1>>O=C(Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1)NC1CCNCC1,,ClCCl,O,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20020032191A1,NCc1ccccc1.O=C1CC(c2ccc(Br)cc2)CC(=O)O1>>Brc1ccc(C2CCN(Cc3ccccc3)CC2)cc1,,Cc1ccccc1,,,,val
US20100152455A1,Nc1ccccc1S.O=Cc1ccc(-c2ccccc2)cc1O>>Oc1cc(-c2ccccc2)ccc1-c1nc2ccccc2s1,,C1COCCO1,,,,val
US05466692,Cc1nc(CO)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nnnn3C(C)(C)C)cc1)C(=O)CC2>>Cc1nc(CO)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CC2,,Cc1ccccc1,,CS(=O)(=O)O,,val
US04260775,CCOC(=O)c1c[nH]nc1N.O=Cc1ccccc1>>CCOC(=O)c1c[nH]nc1NCc1ccccc1,,Cc1ccccc1,,,,val
US04107438,N#CCCCl.Sc1ccc(Cl)cc1>>N#CCCSc1ccc(Cl)cc1,,O,,[Na+].[OH-],,val
US03940434,O=C(O)C1=CCc2cc(C3CCCCCC3)c(Cl)cc21>>O=C(O)C1CCc2cc(C3CCCCCC3)c(Cl)cc21,[Ni],CCO,,[H][H],,val
US20090118200A1,O=C(Nc1ccccc1-n1cccc1)[C@@H]1CCCN1C(=O)CBr.Sc1nnnn1-c1ccccc1>>O=C(Nc1ccccc1-n1cccc1)[C@@H]1CCCN1C(=O)CSc1nnnn1-c1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05776699,C[Si](C)(C)C#Cc1ccc2c(c1)C(=O)CCS2>>C=Cc1ccc2c(c1)C(=O)CCS2,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20090197863A1,CC(C)(C)OC(=O)NCCCC(=O)c1ccc(Br)c(F)c1>>Fc1cc(C2=NCCC2)ccc1Br,,O=CO,,,,val
US05444074,Cc1cc(Cl)cc(C(C)(C)C)c1.O=C1CCC(=O)N1Br>>CC(C)(C)c1cc(Cl)cc(CBr)c1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20090099355A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COP(=O)(OC)c1ccc(Cl)cc1>>COP(=O)(OC)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1,,C1COCCO1,,C1CCC(P(C2CCCCC2)C2CCCCC2)CC1,CC(=O)[O-].[K+],val
US20140274696A1,COC(=O)c1nc(-c2ccc([Si](C)(C)C)c(F)c2F)nc(N)c1OC.ClI>>COC(=O)c1nc(-c2ccc(I)c(F)c2F)nc(N)c1OC,,CCOC(C)=O,ClCCCl,,,val
US20060025433A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CN)CC1.Clc1ncc(Cl)c(Cl)n1>>CC(C)(C)OC(=O)NC1CCC(CNc2nc(Cl)ncc2Cl)CC1,,CCO,,CCN(C(C)C)C(C)C,,val
US07109229B2,CC(C)(C)[Si](C)(C)OCCCBr.COc1ccc2cc[nH]c2c1>>COc1ccc2ccn(CCCO[Si](C)(C)C(C)(C)C)c2c1,,CN(C)C=O,,[H-].[Na+],,val
US20060052392A1,CCOC(=O)CC1c2cc(C)c(C)cc2C(=O)N1c1cccnc1>>Cc1cc2c(cc1C)C(CCO)N(c1cccnc1)C2=O,,CO,,[BH4-].[Na+],,val
US20080045591A1,COc1cc(CCC(=O)C(C)C(=O)c2ccc(O[Si](C)(C)C(C)(C)C)c(OC)c2)ccc1O[Si](C)(C)C(C)(C)C>>COc1cc(CCC(=O)C(C)C(=O)c2ccc(O)c(OC)c2)ccc1O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100009957A1,O=C(NC1CCCCN(C(=O)OCc2ccccc2)CC1)ON1C(=O)CCC1=O.O=C1[C@H]2NCC[C@H]2N1S(=O)(=O)O>>O=C(OCc1ccccc1)N1CCCCC(NC(=O)N2CC[C@@H]3[C@H]2C(=O)N3S(=O)(=O)O)CC1,,CC#N,O,O=C([O-])O.[Na+],,val
US06075036,CCCc1cc(OC)ccn1.COc1ccc(C(=O)CBr)cc1>>CCCc1cc(OC)cc[n+]1CC(=O)c1ccc(OC)cc1.[Br-],,CC(C)=O,,,,val
US20160229814A1,CCN.Nc1ncc(Br)nc1C(=O)O>>CCNC(=O)c1nc(Br)cnc1N,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020115826A1,BrP(Br)Br.O=C(CCCCCCCO)c1ccc2ccccc2c1>>O=C(CCCCCCCBr)c1ccc2ccccc2c1,,CCOCC,,O=C([O-])O.[Na+],,val
US08283365B2,NCc1ccc2[nH]c(C(F)(F)F)cc2c1.O=C(O)c1ccc(C(F)(F)F)nc1>>O=C(NCc1ccc2[nH]c(C(F)(F)F)cc2c1)c1ccc(C(F)(F)F)nc1,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20160083370A1,Cc1ccc(S(=O)(=O)OCCCc2c[nH]c3ccc(F)cc23)cc1.N#Cc1ccnc(N2CCNCC2)n1>>N#Cc1ccnc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)n1,,CC#N,,[I-].[K+],,val
US20080253965A1,COc1ccc(Cc2nc3nc(F)nc(N)c3[nH]2)cc1OC.O=C1CCC(=O)N1I>>COc1cc(I)c(Cc2nc3nc(F)nc(N)c3[nH]2)cc1OC,,CC#N,,O=C(O)C(F)(F)F,,val
US05276045,CNC(=S)C1(c2cccnc2)CCCCC1=O.Nc1ccccc1>>CNC(=S)C1(c2cccnc2)CCCCC1=Nc1ccccc1,Cl[Ti](Cl)(Cl)Cl,CC(Cl)Cl,O,O=C([O-])O.[Na+],,val
US05104960,O=[N+]([O-])c1ccc(-c2nc3ccccc3o2)cc1.Oc1ccccc1>>c1ccc(Oc2ccc(-c3nc4ccccc4o3)cc2)cc1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20090181928A1,C#CCBr.O=S1(=O)CCCC1>>C#CCC1CCCS1(=O)=O,,C1CCOC1,,[Li]CCCC,,val
US20160199330A1,CC(C)[Si](Cl)(C(C)C)C(C)C.Oc1ccc(F)cc1F>>CC(C)[Si](Oc1ccc(F)cc1F)(C(C)C)C(C)C,,CN(C)C=O,,O,c1c[nH]cn1,val
US04530793,C=CCOC(=O)N1C(=O)[C@](CC(=O)OC(C)[Si](C)(C)C)(C(C)O)[C@H]1[S-].C[Si](C)(C)C(C(N)=O)[Si](C)(C)C.[Ag+]>>C=CCOC(=O)N1C(=O)[C@](CC(=O)OC(C)[Si](C)(C)C)(C(C)O[Si](C)(C)C)[C@H]1[S-].[Ag+],,ClCCl,,,,val
US05015645,COC(=O)CC1CCCC(=O)C1.NCCn1cccc1>>O=C1CC2CCCC3(C2)c2cccn2CCN13,,Cc1ccccc1,,CC(=O)O,O,val
US20040242874A1,CON(C)C(=O)c1cc2n(n1)CCC2>>O=Cc1cc2n(n1)CCC2,,C1CCOC1,ClCCl,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090111808A1,C[C@H]1CCCN(CCCOc2ccc(-c3ccnc(Cl)c3)cc2)C1.OCCCN1CCCCC1>>C[C@H]1CCCN(CCCOc2ccc(-c3ccnc(OCCCN4CCCCC4)c3)cc2)C1,,ClCCl,,[Na],,val
US20060194783A1,O=C(NC1(Cc2ccc(OCc3ccccc3)cc2)CCCCN(Cc2ccccc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1>>O=C(NC1(Cc2ccc(O)cc2)CCCCN(Cc2ccccc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1,[Pd],CCO,,,,val
US20140294805A1,CC(=O)NCc1ccc(S(=O)(=O)c2cnc(N(C)C)cn2)cc1.Cl>>CN(C)c1cnc(S(=O)(=O)c2ccc(CN)cc2)cn1.Cl,,CC(C)O,,,,val
US04010202,COc1ccc2c(c1OC)CCC(N)C2=O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COc1ccc2c(c1OC)CCC(NC(=O)C(F)(F)F)C2=O,,CCCCCC,,CCOCC,Cl,val
US20150065482A1,CC1(C)CCC(=O)CC1.CCOC(=O)C(=O)OCC>>CCOC(=O)C(=O)C1CC(C)(C)CCC1=O,,CCO,,C,C[O-].[Na+],val
US20050222231A1,CCOC(=O)[C@H]1C2CCC(=O)C21>>O=C1CCC2C1[C@H]2C(=O)O,,CCO,,[Na+].[OH-],,val
US05347012,Cc1nccn1Cc1csc2ccc3ccccc3c2c1=O.Cl>>Cc1nccn1Cc1csc2ccc3ccccc3c2c1=O.Cl,,CO,,,,val
US20130137865A1,CN(C)C=O.Cn1ncc(C(=O)O)c1CCc1ccc(C(F)(F)F)cc1>>Cn1ncc(C(N)=O)c1CCc1ccc(C(F)(F)F)cc1,,ClC(Cl)Cl,,O=C(Cl)C(=O)Cl,,val
US20130315825A1,COc1ccc(N)c(O)c1.O=[N+]([O-])c1cnc(Cl)c([N+](=O)[O-])c1>>COc1ccc(Nc2ncc([N+](=O)[O-])cc2[N+](=O)[O-])c(O)c1,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20070088018A1,COC(=O)c1ccc(S(=O)(=O)n2nc(C3CCCC3)c3ccccc32)cc1>>O=C(O)c1ccc(S(=O)(=O)n2nc(C3CCCC3)c3ccccc32)cc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20030149107A1,CN(CCOc1ccc(C(=O)CCC(=O)OC(C)(C)C)cc1)Cc1ccccc1F>>CN(CCOc1ccc(C(=O)CCC(=O)O)cc1)Cc1ccccc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090156825A1,COC(=O)CCCCCCC(=O)Nc1ccc(CNC(=O)OC(C)(C)C)cc1.NO.O=C(O)C(F)(F)F>>NCc1ccc(NC(=O)CCCCCCC(=O)NO)cc1.O=C(O)C(F)(F)F,,CO,,[K+].[OH-],,val
US20070185153A1,C=CB1OB(C=C)OB(C=C)O1.O=S(=O)(Oc1cc2c(nn1)OCCC2)C(F)(F)F>>C=Cc1cc2c(nn1)OCCC2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[K+].[K+],val
US20090062345A1,CC1CN(Cc2ccccc2)CCC1=O.C[C@H](O)C[C@H](C)O>>C[C@H]1C[C@H](C)OC2(CCN(Cc3ccccc3)C[C@H]2C)O1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120142705A1,COC(=O)C(Br)CC(C)C.Cc1ccc2c(c1)C(=O)C(=O)N2>>COC(=O)C(CC(C)C)N1C(=O)C(=O)c2cc(C)ccc21,,CN(C)C=O,O,[H-].[Na+],,val
US20100168418A1,BrCCSc1ccccc1.CCOC(=O)C1(CCCn2c(=O)ccc3ccc(OC)cc32)CCNCC1>>CCOC(=O)C1(CCCn2c(=O)ccc3ccc(OC)cc32)CCN(CCSc2ccccc2)CC1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150038438A1,CCOC(=O)c1cc2c(n(Cc3ccccc3)c1=O)-c1ccc(Cl)cc1OC2C>>CC1Oc2cc(Cl)ccc2-c2c1cc(C(=O)O)c(=O)n2Cc1ccccc1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20110190263A1,CC(=O)Oc1cccc2c1CCNC2.CCc1cnc(Cl)nc1>>CCc1cnc(N2CCc3c(O)cccc3C2)nc1,,CC(=O)N(C)C,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US05109002,Br[Mg]c1ccccc1.O=C(CC1CCN(CC2CC2)CC1)c1ccc(F)cc1>>OC(CC1CCN(CC2CC2)CC1)(c1ccccc1)c1ccc(F)cc1,,C1CCOC1,,CCOCC,[Cl-].[NH4+],val
US20080114019A1,CC(=O)c1ccccc1.CCCc1nc2c(N)nc(C)c(C)c2n1CCCON>>CCCc1nc2c(N)nc(C)c(C)c2n1CCCO/N=C(\C)c1ccccc1,,CO,,Cl,c1ccncc1,val
US20160249617A1,Cc1cccc(C(=O)O)c1OCc1ccccc1.O=C(Cl)C(=O)Cl>>Cc1cccc(C(=O)Cl)c1OCc1ccccc1,,C1CCOC1,,CN(C)C=O,,val
US20050176689A1,Cc1ccc(CN(C)C2CC2)cc1C#C[Si](C)(C)C>>C#Cc1cc(CN(C)C2CC2)ccc1C,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20120295931A1,O=C(Cl)C(=O)Cl.O=C(O)c1ccnc(Cl)c1>>O=C(Cl)c1ccnc(Cl)c1,CN(C)C=O,ClCCl,,,,val
US20160115125A1,CI.COC(=O)c1[nH]ccc1Cl>>COC(=O)c1c(Cl)ccn1C,,CN(C)C=O,,[H-].[Na+],,val
US20140128392A1,COC(=O)c1ccc2nc(-c3ccccc3)c(Cl)nc2c1.OB(O)c1ccc(C(F)(F)F)cc1>>COC(=O)c1ccc2nc(-c3ccccc3)c(-c3ccc(C(F)(F)F)cc3)nc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20100120841A1,CI.O=c1[nH]c2ncccc2n1C1CCN([C@@H]2Cc3cccc4cccc2c34)CC1>>Cn1c(=O)n(C2CCN([C@@H]3Cc4cccc5cccc3c45)CC2)c2cccnc21,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20150152108A1,CC1(C)OC[C@H](CO)O1.Nc1cc(Cl)ccn1>>CC1(C)OC[C@H](COc2ccnc(N)c2)O1,,CO,,[Na],,val
US20130059834A1,COC[C@H](C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CCN(C)C)c4cc(Cl)ccc34)nc12>>COC[C@H](C)NC(=O)c1c[nH]c2ncc(-c3nn(CCN(C)C)c4cc(Cl)ccc34)nc12,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US20060063809A1,NC1CCC(C(=O)O)CC1.O=C(Cl)OCc1ccccc1>>O=C(NC1CCC(C(=O)O)CC1)OCc1ccccc1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20150057273A1,CC(C)(C)c1cc(N)n(-c2ccc(F)c(CN3CCOCC3)c2)n1.O=C(Cl)OCC(Cl)(Cl)Cl>>CC(C)(C)c1cc(NC(=O)OCC(Cl)(Cl)Cl)n(-c2ccc(F)c(CN3CCOCC3)c2)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US06248912B1,C[Si](C)(Cl)C1=Cc2ccccc2C1.[Li]C1([Si](C)(C)C)C=CC=C1>>C[Si](C)(C)C[Si](C)(C1=Cc2ccccc2C1)C1C=CC=C1,,C1CCOC1,,O,,val
US20100041684A1,CC(C)(C#N)c1ccc(N)cc1.Nc1ccc(Oc2ccnc(NCCCO)n2)cc1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C#N)c1ccc(NC(=O)Nc2ccc(Oc3ccnc(NCCCO)n3)cc2)cc1,,ClCCl,,,,val
US20050171179A1,C=Cc1ccccc1.CCOC(=O)C(Cl)=NNc1ccc(Cl)cc1>>CCOC(=O)C1=NN(c2ccc(Cl)cc2)C(c2ccccc2)C1,,c1ccccc1,,CCN(CC)CC,,val
US20140155407A1,Cc1ccc(-c2ccccc2)nc1.O=C1CCC(=O)N1Br>>BrCc1ccc(-c2ccccc2)nc1,,ClC(Cl)(Cl)Cl,,,,val
US20140187588A1,C=C(C)CO[C@H]1CCC[C@H](N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)O[C@@H](C)[C@@H]1Oc1ccccc1>>CC(C)CO[C@H]1CCC[C@H](N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)O[C@@H](C)[C@@H]1Oc1ccccc1,[Pd],CCOC(C)=O,,,,val
US20160068547A1,Nc1ccnc(-c2ccccn2)c1[N+](=O)[O-]>>Nc1ccnc(-c2ccccn2)c1N,[Pd],CO,,,,val
US20110311461A1,NC(=O)c1sccc1NC(C(=O)O)c1ccccc1.O[C@H]1CN2CCC1CC2>>NC(=O)c1sccc1NC(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20100267687A1,C[C@@H]1CCCN1CCCOc1ccc(-n2cc(C(=O)N(CCO)CCO)cn2)cc1>>C[C@@H]1CCCN1CCCOc1ccc(-n2cc(C(=O)N3CCOC(O)C3)cn2)cc1,,ClC(Cl)Cl,O,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US06251890B1,BrCc1cccc2cccc(CBr)c12.NC(=O)C(F)(F)F>>O=C(N1Cc2cccc3cccc(c23)C1)C(F)(F)F,,CN(C)C=O,,[H-].[Na+],,val
US05698554,CC(O)C#N.CC=CC(=O)c1ccc(CCCCNC(C)=O)cc1>>CC(=O)NCCCCc1ccc(C(=O)CC(C)C#N)cc1,,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US20160184318A1,CNC1CCN(C(=O)/C=C/c2ccc(C(F)(F)F)cc2Cn2nnc(C)n2)CC1.O=S(=O)(Cl)C1CC1>>Cc1nnn(Cc2cc(C(F)(F)F)ccc2/C=C/C(=O)N2CCC(N(C)S(=O)(=O)C3CC3)CC2)n1,,ClCCl,,CCN(CC)CC,Cl,val
US20160039834A1,Cc1cc(CO)no1.O=C(Cl)c1ccccc1>>Cc1cc(COC(=O)c2ccccc2)no1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20100240702A1,CCC[C@@H](CC(=O)OCC)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccccc21>>CCC[C@@H](CC(=O)O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccccc21,,C1COCCO1,O,[Li+].[OH-],,val
US20140155375A1,CC(=O)Oc1c(C)n(C(C)=O)c2cc(Br)c(F)cc12>>CC(=O)N1c2cc(Br)c(F)cc2C(=O)C1C,,CCO,O,O=S([O-])[O-].[Na+].[Na+],,val
US20050043388A1,COC(=O)c1ccc(OCC(=O)NN)cc1.O=C1Nc2ccc(Br)cc2C1=O>>COC(=O)c1ccc(OCC(=O)NN=C2C(=O)Nc3ccc(Br)cc32)cc1,,CC(=O)O,,,,val
US20030013751A1,C[C@@H](CS(=O)(=O)Cl)C(=O)OCc1ccccc1.N>>C[C@@H](CS(N)(=O)=O)C(=O)OCc1ccccc1,,CCOC(C)=O,ClCCl,,,val
US20090143229A1,CCOC(=S)[S-].Cc1nn(-c2cc(N)c(F)cc2Br)c(=O)n1C(F)F>>Cc1nn(-c2cc3nc(S)sc3cc2Br)c(=O)n1C(F)F,,CN(C)C=O,,Cl,,val
US06544985B2,CC(C)(C)OC(=O)CC(=O)c1cccc(-c2nc(COC3CCCCO3)co2)c1.CCCN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1Cl>>CCCN(C)c1cc2c(cc1Cl)NC(=O)CC(c1cccc(-c3nc(CO)co3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US04889855,Nc1cc(S(N)(=O)=O)c2ccccc2c1N.O=C(O)C(=O)O>>NS(=O)(=O)c1cc2nc(O)c(O)nc2c2ccccc12,,Cl,,O,O,val
US20060046980A1,Brc1ccccc1.COCOc1ccc(Cc2c(C)cc(O[Si](C(C)C)(C(C)C)C(C)C)cc2C)cc1C=O>>COCOc1ccc(Cc2c(C)cc(O[Si](C(C)C)(C(C)C)C(C)C)cc2C)cc1C(O)c1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20030069226A1,CN(C)C=O.COc1cccc(NS(C)(=O)=O)c1C>>COc1cccc(N(C)S(C)(=O)=O)c1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080108629A1,O=C(c1ccccc1C(F)(F)F)N1CCNCC1.S=C(n1ccnc1)n1ccnc1>>O=C(c1ccccc1C(F)(F)F)N1CCN(C(=S)n2ccnc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20040053908A1,ClCCBr.N#Cc1cc2c(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)ccnc2cc1O>>N#Cc1cc2c(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)ccnc2cc1OCCCl,,CCOC(C)=O,CN(C)C=O,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US03953429,CC(=O)OC(C)=O.CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)C3=CC[C@]12C>>CC(=O)O[C@@H]1CC[C@]2(C)C3=CC[C@]4(C)[C@@H](C(C)=O)CC[C@H]4[C@@H]3CC[C@H]2C1,,c1ccncc1,,O,,val
US20040002526A1,COC(=O)c1ccc(-c2ccc(C=O)o2)cc1>>O=Cc1ccc(-c2ccc(C(=O)O)cc2)o1,,CO,O,Cl,[Li+].[OH-],val
US20150141644A1,CC(C)(C)C(=O)Nc1cc(C(F)(F)F)c(Br)cn1.CN(C)C=O>>CC(C)(C)C(=O)Nc1cc(C(F)(F)F)c(C=O)cn1,,C1CCOC1,,Cl,[Li]CCCC,val
US20110183985A1,CC(=O)Cl.Oc1ccc(F)c(Br)c1>>CC(=O)Oc1ccc(F)c(Br)c1,,ClCCl,,CCN(CC)CC,,val
US05017724,CC(C)(C)NC(N)=O.Cc1ccc(O)c2c1C1CCCCC1C2=O>>Cc1cc(C(C)(C)C)c(O)c2c1C1CCCCC1C2=O,,O,,O=S(=O)(O)O,,val
US20090181964A1,CC(=N)NS(=O)(=O)c1cccc(C(=O)C(C(=O)c2cc(F)cc(F)c2)=C2Nc3ccc([N+](=O)[O-])cc3N2)c1>>CC(=N)NS(=O)(=O)c1cccc(C(=O)C(C(=O)c2cc(F)cc(F)c2)=C2Nc3ccc(N)cc3N2)c1,[Pd],CCOC(C)=O,,,,val
US20070259864A1,CC(C)(C)OC(=O)N1CC2CN(CCN(CCOc3ccc(C#N)cc3)C(N)=O)CC(C1)O2>>N#Cc1ccc(OCCN(CCN2CC3CNCC(C2)O3)C(N)=O)cc1,,C1COCCO1,,Cl,,val
US20130102586A1,CN1CCN(Cc2ccc(Br)cc2)CC1.COc1ccc(Cn2ccc3cc(B4OC(C)(C)C(C)(C)O4)cnc32)cc1>>COc1ccc(Cn2ccc3cc(-c4cccc(CN5CCN(C)CC5)c4)cnc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030191118A1,COC(=O)[C@H](Cc1ccc(-c2ccccc2C(=O)O)cc1)NC(=O)c1c(Cl)cccc1Cl.CS(N)(=O)=O>>COC(=O)[C@H](Cc1ccc(-c2ccccc2C(=O)NS(C)(=O)=O)cc1)NC(=O)c1c(Cl)cccc1Cl,,C1CCOC1,CCOC(C)=O,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20130261128A1,C[Si](C)(C)CCOCn1cc(C(F)(F)F)nc1-c1ccc(Br)nc1.OB(O)c1ccc(OCc2ccccc2)cc1>>C[Si](C)(C)CCOCn1cc(C(F)(F)F)nc1-c1ccc(-c2ccc(OCc3ccccc3)cc2)nc1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20080161187A1,COc1cnccc1C#N>>COc1cnccc1CN,[Pd],CCO,,N,,val
US20050256098A1,COc1ccc(CNc2cccnc2C#N)c(OC)c1>>COc1ccc(C=Nc2cccnc2CN)c(OC)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080076745A1,CC(C)(C)OC(=O)NCC[C@H](NC(=O)OCc1ccccc1)C(=O)NCC(O)CNC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NCC[C@H](N)C(=O)NCC(O)CNC(=O)OC(C)(C)C,[Pd],CO,,,,val
US20070027112A1,C=CCCCC(=O)c1ccc(-c2ccccc2)cc1>>C=CCCCC(O)c1ccc(-c2ccccc2)cc1,,CCOCC,,O,,val
US20060135578A1,CCOP(=O)(CP(=O)(OCC)OCC)OCC.COc1cc(COc2nn(-c3ccccc3)cc2C=O)ccc1OCc1nc(-c2cccc(C#N)c2)oc1C>>CCOP(=O)(/C=C/c1cn(-c2ccccc2)nc1OCc1ccc(OCc2nc(-c3cccc(C#N)c3)oc2C)c(OC)c1)OCC,,O,,CN(C)C=O,[H-].[Na+],val
US20080306124A1,CCc1cc(C#N)ccc1S(N)(=O)=O.NO>>CCc1cc(C(=N)NO)ccc1S(N)(=O)=O,,C1CCOC1,,,,val
US20110059954A1,Cc1nc(Cl)cc(C(=O)c2cc(C)c3c(c2)oc(=O)n3C)n1.O=c1[nH]c2ncccc2n1C1CCNCC1>>Cc1nc(C(=O)c2cc(C)c3c(c2)oc(=O)n3C)cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20080255133A1,COC(=O)c1cc2c(C)n(C)nc2c(F)c1Nc1ccccc1F.O=C1CCC(=O)N1I>>COC(=O)c1cc2c(C)n(C)nc2c(F)c1Nc1ccc(I)cc1F,,CCOC(C)=O,CN(C)C=O,O=C(O)C(F)(F)F,,val
US20110053953A1,Cc1cc(Br)cnc1Br.N#C[Cu]C#N>>Cc1cc(Br)cnc1C#N,,CN(C)C=O,,,,val
US20120232068A1,CC(C#N)c1cncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)c1.O.[OH-]>>CC(C(=O)O)c1cncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)c1,,CCO,O,Cl,,val
US20030114443A1,CC(C)C(=O)Cl.O=C(N1CCC(Cc2ccccc2)CC1)C(F)(F)F>>CC(C)C(=O)c1ccc(CC2CCN(C(=O)C(F)(F)F)CC2)cc1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20030040523A1,C[C@@H](N)CO.Nc1cc(Cl)nc(SCc2ccccc2F)n1>>C[C@H](CO)Nc1cc(N)nc(SCc2ccccc2F)n1,,CCN(CC)CC,,[Cl-].[NH4+],,val
US07192948B2,CCOC(=O)c1nc2n(c(=O)c1OCc1ccccc1)CC(=O)N2>>CCOC(=O)c1nc2n(c(=O)c1O)CC(=O)N2,,O=C(O)C(F)(F)F,,,,val
US20150183741A1,COC(=O)C1CC2CCC(C1)N2.C[C@H]1CC[C@@H](Oc2ccc3c(C=O)cccc3c2C(F)(F)F)CC1>>COC(=O)C1CC2CCC(C1)N2Cc1cccc2c(C(F)(F)F)c(O[C@@H]3CC[C@H](C)CC3)ccc12,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20140045846A1,O=c1[nH]c(-c2ccccc2)c(OCCCN2CCCCC2)c2ccc([N+](=O)[O-])cc12>>Nc1ccc2c(OCCCN3CCCCC3)c(-c3ccccc3)[nH]c(=O)c2c1,[Pd],C1COCCO1,,C1=CCCCC1,,val
US20100210704A1,CC(=O)NNc1cc(SCC(F)(F)F)c(C)cc1F.O=C(Cl)CC(=O)Cl>>CC(=O)N1C(=O)CC(=O)N1c1cc(SCC(F)(F)F)c(C)cc1F,,C1CCOC1,,,,val
US20030166639A1,CC(C)(C)OC(=O)Nc1ccc(F)cc1NC(=O)CC(=O)c1cccc(-c2ccncc2)c1>>O=C1CC(c2cccc(-c3ccncc3)c2)=Nc2ccc(F)cc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060004046A1,N[C@@H]1C[C@H]1c1ccccc1.O=C1CSC(=S)N1>>O=C1CSC(N[C@@H]2C[C@H]2c2ccccc2)=N1,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4nccs4)cc2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4nccs4)cc2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20050256125A1,Cc1ccc(S(=O)(=O)O)cc1.Nc1nc(=O)c2ncn(COCCO)c2[nH]1>>Nc1ccc2c(c1)NC(=O)C2,,CCO,,,,val
US20100292233A1,CC(C)(C)OC(=O)CC1CCn2c1cc1cc(-c3noc(-c4cc(Br)cc(OC(F)(F)F)c4)n3)ccc12.OB(O)c1cccnc1>>CC(C)(C)OC(=O)CC1CCn2c1cc1cc(-c3noc(-c4cc(OC(F)(F)F)cc(-c5cccnc5)c4)n3)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,c1ccccc1,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20100234485A1,CCCC[Sn](CCCC)(CCCC)OC.O=C(O)c1ccc(C(=O)c2ccccc2)cc1>>CCCC[Sn](CCCC)(CCCC)OC(=O)c1ccc(C(=O)c2ccccc2)cc1,,ClCCCl,,,,val
US20110070161A1,COc1ccc(Cl)c(N)c1.O=C(Cl)COCc1ccccc1>>COc1ccc(Cl)c(NC(=O)COCc2ccccc2)c1,,ClCCl,,CCN(CC)CC,Cl,val
US20100135999A1,CCCCOC(=O)N1CCN(C(=O)CNC(=O)c2cc(O)c3ccc(C)cc3n2)CC1.O=C(CBr)OCc1ccccc1>>CCCCOC(=O)N1CCN(C(=O)CNC(=O)c2nc3cc(C)ccc3c(C(=O)OCc3ccccc3)c2OC)CC1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US06177423B1,COc1cc2c3c(cccc3c1)C(=O)N(O)C2=O.O=C1CCC(=O)N1Br>>COc1cc2c3c(cccc3c1Br)C(=O)N(O)C2=O,,CC(=O)O,,,,val
US20130338134A1,CC=O.COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CC5CCNCC5)cc4c3N(C)C2=O)c1F>>CCN1CCC(Cc2cc3c4c(cnc3[nH]2)CN(c2c(F)c(OC)cc(OC)c2F)C(=O)N4C)CC1,,C1CCOC1,CO,[BH3-]C#N.[Na+],,val
US20110124637A1,CCOC(=O)c1ccc(NC(=O)OC(C)(C)C)cn1>>CC(C)(C)OC(=O)Nc1ccc(CO)nc1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04146715,Nc1nc2nc[nH]c2c(=O)[nH]1.O=C(OCCCOCCl)c1ccccc1>>Nc1nc2c(ncn2COCCCOC(=O)c2ccccc2)c(=O)[nH]1,,c1ccccc1,,CCN(CC)CC,,val
US20130324501A1,COC(=O)c1cccn1S(=O)(=O)c1ccccc1>>O=C(O)c1cccn1S(=O)(=O)c1ccccc1,,C1CCOC1,CO,[K+].[OH-],,val
US20140051672A1,COc1cc(-n2cccn2)ccc1-c1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)nn1>>COc1cc(-n2cccn2)ccc1-c1ccc(OC2CCNCC2)nn1,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20070254867A1,BrCCOC1CCCCO1.Oc1ccc(N2CCOCC2)cc1>>c1cc(N2CCOCC2)ccc1OCCOC1CCCCO1,,CN(C)C=O,,[H-].[Na+],,val
US20020094963A1,CC(=O)O[C@@H]1CO[C@H](n2c(Br)nc3cc(Cl)c(Cl)cc32)C[C@@H]1OC(C)=O>>O[C@@H]1CO[C@H](n2c(Br)nc3cc(Cl)c(Cl)cc32)C[C@@H]1O,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20020173646A1,COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1O.ClCCCBr>>COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCCCl,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20030130213A1,FF.N#Cc1nccnc1Cl>>N#Cc1nc(F)cnc1Cl,,CC#N,,,,val
US20160137649A1,Fc1cc(N2CCOCC2)ccc1CN1CC2CNCC2C1.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O>>O=C(ON1C(=O)CCC1=O)N1CC2CN(Cc3ccc(N4CCOCC4)cc3F)CC2C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05565463,N#CC=Cc1ccc(OCc2ccccc2)cc1>>N#CCCc1ccc(OCc2ccccc2)cc1,,CO,,[Mg],,val
US20150266824A1,CCOC(=O)[C@@H]1CC[C@@H](n2ncc(C(=O)N(CC(=O)c3c(Cl)cccc3OC)Cc3cc(F)cc(F)c3)c2C(F)(F)F)CC1>>CCOC(=O)[C@@H]1CC[C@@H](n2ncc(C(=O)N(CC(=O)c3c(O)cccc3Cl)Cc3cc(F)cc(F)c3)c2C(F)(F)F)CC1,,ClCCl,,BrB(Br)Br,,val
US06060479,C1CCOC1.CC(C)NC(C)C.COC(=O)c1ccccc1C#N.Cc1nc2ccc(F)cc2c(=O)n1-c1cccnc1Cl.[Li]CCCC>>COC(=O)c1ccccc1C#N.Cc1ncccc1-n1c(C=C(O)c2ccccc2C#N)nc2ccc(F)cc2c1=O,,C1CCOC1,,,,val
US20150266895A1,O=Cc1nc(Cl)cc2c1c(I)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1>>OCc1nc(Cl)cc2c1c(I)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1,,CO,ClCCl,[BH4-].[Na+],,val
US20140155415A1,O=S(=O)(N=Cc1ccccc1)c1ccc2c(c1)OCCCO2.c1cc2sccc2cn1>>O=S(=O)(NC(c1ccccc1)c1cc2cnccc2s1)c1ccc2c(c1)OCCCO2,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US05478855,CCOc1cc(C(C)(C)C)ccc1C(N)CO.O=C(Cl)c1c(F)cccc1F>>CCOc1cc(C(C)(C)C)ccc1C(CO)NC(=O)c1c(F)cccc1F,,C1CCOC1,,CCN(CC)CC,,val
US05075461,CC(=O)C(OC(=O)c1ccccc1)C(=O)C=CO>>Cc1occc(=O)c1OC(=O)c1ccccc1,,CC(=O)O,,,,val
US20040142981A1,CN(c1ccc(Cl)cc1)S(=O)(=O)c1cccc(C(=O)Cl)c1.Nc1ccc(Br)cc1-c1noc(=O)[nH]1>>CN(c1ccc(Cl)cc1)S(=O)(=O)c1cccc(C(=O)Nc2ccc(Br)cc2-c2noc(=O)[nH]2)c1,,ClCCl,c1ccncc1,,,val
US04195041,Cc1ccc([N+](=O)[O-])cc1>>Nc1ccc(C=O)cc1,,CN(C)C=O,,CCO,[Na+].[OH-],val
US04804661,COc1cc(OC)cc(C(=O)Cl)c1.Clc1ccc(CCN2CCNCC2)cc1>>COc1cc(OC)cc(C(=O)N2CCN(CCc3ccc(Cl)cc3)CC2)c1.Cl,,ClCCl,,CCOCC,,val
US20020161041A1,CC(C)(C)[Si](C)(C)Oc1ccc([C@@H]2CC[C@@H](O)CC2)c(O[Si](C)(C)C(C)(C)C)c1.CCN=C=O>>CCNC(=O)O[C@@H]1CC[C@@H](c2ccc(O[Si](C)(C)C(C)(C)C)cc2O[Si](C)(C)C(C)(C)C)CC1,,CC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20050187247A1,C1CCN(C2CCNCC2)CC1.COc1cc(Nc2c(C#N)cnc3cc(OCCCCl)c(OC)cc23)c(Cl)cc1Cl>>COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCC(N5CCCCC5)CC4)c(OC)cc23)c(Cl)cc1Cl,,COCCOC,,,,val
US05859007,C1CCOC1.C=CCC(COC)(C(=O)O)C(=O)O.CC(C)N(C(=O)CNc1ccccc1Nc1ccccc1)c1ccccc1.ClCCl>>C=CCC1(COC)C(=O)N(CC(=O)N(c2ccc(OC)cc2)C(C)C)c2ccccc2N(c2ccccc2)C1=O,,C1CCOC1,ClCCl,O=C(Cl)C(=O)Cl,,val
US06518268B1,CCCNCCC.O=Cc1cc([N+](=O)[O-])ccc1F>>CCCN(CCC)c1ccc([N+](=O)[O-])cc1C=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150329523A1,Cc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)cc1.Nc1cccc(OCCOCCOCCO)c1>>Cc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4cccc(OCCOCCOCCO)c4)n3)c3ccccc23)cc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20070105919A1,Nc1nc(-c2ccco2)c(C(=O)C2CCOCC2)s1.O=C(Cl)c1ccccc1OC(F)(F)F>>O=C(Nc1nc(-c2ccco2)c(C(=O)C2CCOCC2)s1)c1ccccc1OC(F)(F)F,CN(C)c1ccncc1,c1ccncc1,,O,,val
US06500817B1,CN.Cc1nc(Cl)sc1S(=O)(=O)Cl>>CNS(=O)(=O)c1sc(Cl)nc1C,,ClCCl,,CO,O,val
US04256757,CCCCCCC#CO.CCOCC.CS(=O)(=O)Cl.O.[Li]CCCC>>CS(=O)(=O)OCC#CCCCCCOC1CCCCO1,,CCCCCC,,,,val
US20070149562A1,CC(=N)NOC(=O)C1CCC(=O)CC1>>Cc1noc(C2CCC(=O)CC2)n1,,CCO,O,CC(=O)[O-].[Na+],,val
US05166204,CN(C)CCN1C(=O)c2ccc3[nH]c4ccccc4c3c2C1=O.Cl>>CN(C)CCN1C(=O)c2ccc3[nH]c4ccccc4c3c2C1=O.Cl,,ClC(Cl)Cl,,,,val
US20080027067A1,CC(C)(C)[Si](OC1CCN(c2ccccc2S(=O)(=O)Nc2nccs2)C1=O)(c1ccccc1)c1ccccc1>>O=C1C(O)CCN1c1ccccc1S(=O)(=O)Nc1nccs1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20070142411A1,CSc1ccc(-c2cc(C)cc(=O)[nH]2)cc1.O=S([O-])OO>>Cc1cc(-c2ccc(S(C)(=O)=O)cc2)[nH]c(=O)c1,,O,,CO,,val
US20080306069A1,O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(NC1CCN(C(=O)C(F)(F)F)CC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl,,C1CCOC1,,CCN(CC)CC,Cl,val
US20070219235A1,CN1CCNCC1.Nc1cc(F)c([N+](=O)[O-])cc1C(=O)Nc1ccc2cn[nH]c2c1.O=C(Nc1ccc2cn[nH]c2c1)c1cc([N+](=O)[O-])c(F)cc1Cl>>CN1CCN(c2cc(N)c([N+](=O)[O-])cc2C(=O)Nc2ccc3cn[nH]c3c2)CC1,,C1COCCO1,,[NH4+].[OH-],,val
US05059611,CCCCCCCCCCCC(=O)CP(=O)(OC)OC.C[Si](C)(C)c1cc(C=O)co1>>CCCCCCCCCCCC(=O)C=Cc1coc([Si](C)(C)C)c1,,C1CCOC1,,[H-].[Na+],,val
US20120214767A1,C=Cc1ccc2c(c1)OCCC2=O.CCCc1ccc(C(=O)F)cc1>>C=Cc1ccc2c(c1)OCC(C(=O)c1ccc(CCC)cc1)C2=O,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20130317026A1,C=Cc1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C(C)C)c2n1.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>Cc1cc(C)c(CNC(=O)c2cc(C(O)CO)nc3c2cnn3C(C)C)c(=O)[nH]1,O=[Os](=O)(=O)=O,ClCCl,,CO,O,val
US20080242655A1,C=COCCONC(=O)c1c(Nc2ccc(I)cc2F)c2cnccc2n1C>>Cn1c(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c2cnccc21,,CO,,Cl,O=C([O-])O.[Na+],val
US20130116430A1,O=S(Cl)Cl.O=[N+]([O-])c1cnc(O)c(-n2ccnn2)c1.O=[N+]([O-])c1cnc(O)c(-n2nccn2)c1>>O=[N+]([O-])c1cnc(Cl)c(-n2ccnn2)c1.O=[N+]([O-])c1cnc(Cl)c(-n2nccn2)c1,,CN(C)C=O,,,,val
US20060173048A1,CCBr.Cc1ccc(-c2[nH]c(-c3c(C)cc(C)cc3C)nc2-c2ccncc2)cc1>>CCn1c(-c2c(C)cc(C)cc2C)nc(-c2ccncc2)c1-c1ccc(C)cc1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20050014811A1,CC(C)(C)OC(=O)Nc1nc2ccc(OS(=O)(=O)c3ccc(F)cc3)cc2[nH]1.COc1ccc(CBr)cc1Cl>>COc1ccc(CN(C(=O)OC(C)(C)C)c2nc3ccc(OS(=O)(=O)c4ccc(F)cc4)cc3[nH]2)cc1Cl,,CN(C)C=O,,O,[H-].[Na+],val
US20130203758A1,COC(=O)C(NC(=O)c1ccc(Nc2nc(NC3(c4ccc(Cl)cc4)CC3)nc(OCC(F)(F)F)n2)cc1)C1CCCN(C(=O)OC(C)(C)C)C1>>COC(=O)C(NC(=O)c1ccc(Nc2nc(NC3(c4ccc(Cl)cc4)CC3)nc(OCC(F)(F)F)n2)cc1)C1CCCNC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04782162,CC=C(C(=O)OCC)c1csc(NC(C)=O)n1>>CC=C(C(=O)O)c1csc(N)n1,,O,,Cl,[K+].[OH-],val
US20050070556A1,C=O.CCNC(=O)OCC>>CCOC(=O)N(CC)CO,,O,,,,val
US20100137278A1,Clc1nc2ccccc2[nH]1.Nc1ccc(Oc2nccnc2C2CCOCC2)cc1>>c1ccc2[nH]c(Nc3ccc(Oc4nccnc4C4CCOCC4)cc3)nc2c1,,CC(C)O,,,,val
US20070191603A1,CC(C)(C)OC(=O)c1ccc(NC(=O)c2ccc3c(c2)N(S(=O)(=O)c2cccc(Cl)c2)CCS3=O)cc1>>O=C(O)c1ccc(NC(=O)c2ccc3c(c2)N(S(=O)(=O)c2cccc(Cl)c2)CCS3=O)cc1,,O=CO,,O,,val
US20010037033A1,CC(=O)Nc1ccc2ccccc2c1-c1c(P(=O)(c2ccccc2)c2ccccc2)ccc2ccccc12>>CCNc1ccc2ccccc2c1-c1c(P(c2ccccc2)c2ccccc2)ccc2ccccc12,,C1CCOC1,,,,val
US20080234276A1,[O-][n+]1nc(-c2cc[nH]n2)nc2ccccc21>>c1ccc2nc(-c3cc[nH]n3)nnc2c1,[Pd],CO,,,,val
US20140170110A1,COc1ncccc1Nc1ncc([N+](=O)[O-])c(SC#N)n1.NC1CCCOC1>>COc1ncccc1Nc1ncc([N+](=O)[O-])c(NC2CCCOC2)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20040242868A1,Cc1ccc(N)cc1-c1ccc(C(=O)NCC2CC2)cc1.O=C(O)c1ccc(-c2ccc(Cl)cc2)o1>>Cc1ccc(NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)cc1-c1ccc(C(=O)NCC2CC2)cc1,,C1CCOC1,,,,val
US20080027099A1,CI.COC(=O)c1ccc(OC)c(OC2CCCC2)c1NC(C)=O>>COC(=O)c1ccc(OC)c(OC2CCCC2)c1N(C)C(C)=O,,C1CCOC1,,[H-].[Na+],,val
US20100136142A1,COc1cc(C#N)ccc1C=O>>N#Cc1ccc(C=O)c(O)c1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20090275567A1,Cc1ncc(-c2nc(NC3CCN(S(=O)(=O)C4CCN(C(=O)OCc5ccccc5)CC4)CC3)ncc2F)n1C(C)C>>Cc1ncc(-c2nc(NC3CCN(S(=O)(=O)C4CCNCC4)CC3)ncc2F)n1C(C)C,[Pd],CO,,[H][H],,val
US20130109679A1,CC1OS(=O)(=O)N(C(=O)OC(C)(C)C)C1C.CCOC(=O)c1ccc2cc(C(=O)OCC)[nH]c2c1>>CCOC(=O)c1ccc2cc(C(=O)OCC)n(C(C)C(C)NC(=O)OC(C)(C)C)c2c1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20050059668A1,CS(=O)(=O)c1ccc(C2=CCCCCC2)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1>>CS(=O)(=O)c1ccc(C2CCCCCC2)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1,[Pd],CO,,,,val
US20090270379A1,CCOC(=O)c1cn(C2CC2)c2c(OC(F)F)c(C3=CC4CN(C(=O)OC(C)(C)C)CCN4C3)ccc2c1=O>>CCOC(=O)c1cn(C2CC2)c2c(OC(F)F)c(-c3cc4n(c3)CCN(C(=O)OC(C)(C)C)C4)ccc2c1=O,[Pd],CO,,,,val
US20090270460A1,CCOC(=O)C(=O)C(=CN(C)C)C1CC1.NNc1c(Cl)cccc1Cl>>CCOC(=O)c1c(C2CC2)cnn1-c1c(Cl)cccc1Cl,,CCO,,Cl,Cl,val
US20090318523A1,CCCOc1c2c(c(OCCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)OCC)cc1C)C2>>CCCOc1c2c(c(OCCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)cc1C)C2,,CCO,,[Na+].[OH-],,val
US20130252936A1,N#CC1CCCNC1.O=C(O)Cn1nc(-c2ccccc2)c2c(Cl)c(-c3ccccc3)nnc21>>N#CC1CCCN(C(=O)Cn2nc(-c3ccccc3)c3c(Cl)c(-c4ccccc4)nnc32)C1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130217732A1,N#Cc1ccc(N2C(=O)CC[C@@H]2COC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1C(F)(F)F>>N#Cc1ccc(N2C(=O)CC[C@@H]2CO)cc1C(F)(F)F,,C1COCCO1,O,Cl,,val
US20080275062A1,C=CCN.Clc1cc(Cl)ncn1>>C=CCNc1cc(Cl)ncn1,,C1CCOC1,,,,val
US05451687,Cc1ccc(C(=O)OC(=O)[C@H](O)[C@@H](O)C(=O)OC(=O)c2ccc(C)c(C)c2)cc1C.O>>Cc1ccc(C(=O)OC(=O)[C@@H](O)[C@H](O)C(=O)OC(=O)c2ccc(C)c(C)c2)cc1C.O,,Cc1ccccc1,,,,val
US20070270422A1,O=C(Nc1ccc(Oc2ccccc2)c(F)c1)c1ccc(Cl)c(Cl)c1.O=C1CCC(=O)O1>>O=C(O)CCC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2F)cc1,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20110065702A1,O=C1Cc2ccccc2N1.O=Cc1ccc2c(/C=C/c3ccccc3)n[nH]c2c1>>O=C1Nc2ccccc2/C1=C\c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1,,CO,,C1CCNCC1,,val
US05241107,Cc1ccccc1.O=C([O-])C1CCc2cccc3c2C1c1ccccc1-3>>COC(=O)c1ccc2cccc3c2c1-c1ccccc1-3,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20160068559A1,CC1(C)O[C@@H]2[C@@H](CN)O[C@@H](n3cnc4c(N)ncnc43)[C@@H]2O1.O=CCCN1C(=O)c2ccccc2C1=O>>CC1(C)O[C@@H]2[C@@H](CNCCCN3C(=O)c4ccccc4C3=O)O[C@@H](n3cnc4c(N)ncnc43)[C@@H]2O1,,ClCCCl,,O=C([O-])O.[Na+],,val
US20030181726A1,COc1ccc(C(CCNCc2ccccc2)c2ccc(OC)cc2)cc1.O=[N+]([O-])c1cc(OC[C@@H]2CO2)ccc1OCc1ccccc1>>COc1ccc(C(CCN(Cc2ccccc2)C[C@H](O)COc2ccc(OCc3ccccc3)c(N)c2)c2ccc(OC)cc2)cc1,[Fe],O,,CCO,[Cl-].[NH4+],val
US06720463B1,C=COCCCC.CC(C)COC(=O)[C@@H](C)O>>CCCCOC(C)O[C@H](C)C(=O)OCC(C)C,,CCOC(C)=O,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US03968168,CC(C)(C)c1ccccc1.O=CC(Cl)(Cl)Cl>>CC(C)(C)c1ccc(C(O)C(Cl)(Cl)Cl)cc1,,O,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20060166993A1,CC(=O)NC(C)c1nnc(-c2ccc(Br)cc2)[nH]c1=O>>Cc1nc(C)n2nc(-c3ccc(Br)cc3)[nH]c(=O)c12,,ClCCCl,,O=P(Cl)(Cl)Cl,,val
US20080207654A1,CCCCc1nc(C)n(Cc2nc3ccccc3[nH]2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CI>>CCCCc1nc(C)n(Cc2nc3ccccc3n2C)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20060052365A1,C=C[C@H](O)[C@H]1CO1.O=C1NC(=O)c2ccccc21>>C=C[C@H]([C@H]1CO1)N1C(=O)c2ccccc2C1=O,,Cc1ccccc1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080312226A1,CCc1sc(N2CCNCC2)nc1-c1ccccc1.Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C>>CCc1sc(N2CCN(C(=O)Nc3onc(C)c3C)CC2)nc1-c1ccccc1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US04521604,CC1NCCNC1=O.O=C(Cl)C(Cl)Cl>>CC1C(=O)NCCN1C(=O)C(Cl)Cl,,ClCCl,O,[Na+].[OH-],,val
US20040209892A1,CNC(=O)c1cccc(Oc2ccc(N)c([N+](=O)[O-])c2)c1>>CNC(=O)c1cccc(Oc2ccc(N)c(N)c2)c1,[Pd],CO,,,,val
US20110178053A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCCCC(=O)O>>CC(C)(C)OC(=O)CNCCCC(=O)O,,C1COCCO1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US05234946,O=S(Cl)Cl.OCc1cc(-c2ccsc2)cs1>>ClCc1cc(-c2ccsc2)cs1,,ClC(Cl)Cl,,CN(C)C=O,O=C([O-])O.[Na+],val
US20060276533A1,COC(=O)c1sc(C2=CCCCC2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C1CCN(C(=O)OC(C)(C)C)CC1>>COC(=O)c1sc(C2=CCCCC2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C1CCNCC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20110275762A1,CC1(C)OB(c2ccc(N3CCOCC3)nc2)OC1(C)C.Clc1nc(N2CCOCC2)nc(N2CCOCC2)n1>>c1cc(N2CCOCC2)ncc1-c1nc(N2CCOCC2)nc(N2CCOCC2)n1,,CCCCCC,CCOC(C)=O,,,val
US20110008259A1,O=C1CCC(=O)N1c1ccc([N+](=O)[O-])c(C(F)(F)F)c1>>O=[N+]([O-])c1ccc(N2CCCC2)cc1C(F)(F)F,,C1CCOC1,,,,val
US04030925,Nc1ccc(NNC=O)cc1.S=C=Nc1ccccc1>>O=CNNc1ccc(NC(=S)Nc2ccccc2)cc1,,CC#N,,,,val
US05821246,Nc1ccc([N+](=O)[O-])cc1Cl.O=S(=O)(Cl)c1ccccc1>>O=[N+]([O-])c1ccc(NS(=O)(=O)c2ccccc2)c(Cl)c1,,c1ccncc1,,,,val
US20150011580A1,CCCCCCCBr.Cc1cc(C)c2c(n1)N(C)CC2>>CCCCCCCCc1cc(C)c2c(n1)N(C)CC2,,C1CCOC1,,[Li]CCCC,,val
US20040138148A1,CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.NC(=O)c1ccc(Cc2ccccc2O)cc1>>NC(=O)c1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1,,Cc1ccccc1,,,,val
US20070099901A1,CCCCc1nc2cnc3cccnc3c2n1CCCC(=O)O.O=C(Cl)C(=O)Cl>>CCCCc1nc2cnc3cccnc3c2n1CCCC(=O)Cl,CN(C)C=O,ClCCl,,,,val
US20020169185A1,COC(=O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1>>COC(=O)c1cc(N)cc([N+](=O)[O-])c1,[Pd],CC#N,,CCN(CC)CC,O=CO,val
US20050171087A1,CNc1ccccc1.O=[N+]([O-])c1cc(Cl)ccc1F>>CN(c1ccccc1)c1ccc(Cl)cc1[N+](=O)[O-],,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20060241127A1,Clc1ccnc2[nH]ccc12.Nc1ccc(O)c(F)c1>>Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1,,O,,[K+].[OH-],,val
US20150011528A1,CCC(C(=O)OC)n1c(=NC(=O)c2ccc(C)cc2)sc2ccc(Br)cc21>>CCC(C(=O)O)n1c(=NC(=O)c2ccc(C)cc2)sc2ccc(Br)cc21,,CO,,C1CCOC1,[Na+].[OH-],val
US20140155389A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc2c(c1)CNCC2>>COc1ccc2c(c1)CN(C(=O)OC(C)(C)C)CC2,,ClCCl,,CCN(CC)CC,O,val
US20040024010A1,CN.O=C(O)CCc1c(C=C2C(=O)Nc3ccccc32)[nH]c2c1CCCC2>>CNC(=O)CCc1c(C=C2C(=O)Nc3ccccc32)[nH]c2c1CCCC2,,CN(C)C=O,,O,O=C(n1ccnc1)n1ccnc1,val
US20120035214A1,COC[C@H](C)COCc1ccc([C@@]2(O)CCN(C(=O)OC(C)(C)C)C[C@@H]2c2noc(-c3ccccc3CCNC(C)=O)c2Br)cc1>>COC[C@H](C)COCc1ccc([C@@]2(O)CCNC[C@@H]2c2noc(-c3ccccc3CCNC(C)=O)c2Br)cc1,,ClCCl,,C1COCCO1,Cl,val
US04113731,Cn1c(N)c(-c2ccccc2)c2ccccc21.N#CO[K]>>Cn1c2ccccc2c2c3ccccc3c(=O)[nH]c21,,CCCCCC,,Cl,,val
US20090170913A1,CN(CC1CCN(C(=O)OC(C)(C)C)C1)c1nc2ccc(NC(=O)c3ccc(-c4ccc(F)cc4)cc3)cc2s1>>CN(CC1CCNC1)c1nc2ccc(NC(=O)c3ccc(-c4ccc(F)cc4)cc3)cc2s1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140274696A1,COC(=O)c1nc(-c2ccc(OC(F)F)c(F)c2)c(F)c(N)c1Cl>>Nc1c(F)c(-c2ccc(OC(F)F)c(F)c2)nc(C(=O)O)c1Cl,,CO,,[Na+].[OH-],,val
US20070299258A1,CC(C)(C)OC(=O)NC(CCO)C1CCOCC1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)NC(CCOS(C)(=O)=O)C1CCOCC1,,ClCCl,,CCN(CC)CC,,val
US20090186879A1,O=[N+]([O-])c1cccc([N+](=O)[O-])c1NCCCO>>Nc1cccc(N)c1NCCCO,[Pd],C1CCOC1,,,,val
US20030149001A1,C=C(OCC)c1c(C)c2cnc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)C(C)(C)C4)cn3)nc2n(C2CCCC2)c1=O.Cl>>CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNC(C)(C)C4)cn3)nc2n(C2CCCC2)c1=O.Cl,,CCOC(C)=O,,,,val
US20110059948A1,C=CC(=O)OCC.CCOC(C)=O.O=Cc1ccccc1>>CCC=C(C(=O)OCC)C(O)c1ccccc1,,CCOC(C)=O,,C1CN2CCN1CC2,,val
US20100048453A1,COC(=O)C(C)(C)Br.Cc1cc(C=O)c(C)cc1O>>COC(=O)C(C)(C)Oc1cc(C)c(C=O)cc1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040078905A1,O=C(O)[C@@H]1C[C@@H](O)CN1.O=[N+]([O-])c1ccc(F)cc1>>Nc1ccc(N2CC(O)CC2C(=O)O)cc1,,O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20050113379A1,CC(C)(C)[Si](C)(C)Cl.N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1O>>CC(C)(C)[Si](C)(C)O[C@H]1CN(C(=O)OCc2ccccc2)C[C@H]1N,,ClCCl,,c1c[nH]cn1,,val
US20060148855A1,Cc1nc(-c2ccc(F)cc2)ccc1C(=O)O.Cc1nc2cc(N)ccc2s1>>Cc1nc2cc(NC(=O)c3ccc(-c4ccc(F)cc4)nc3C)ccc2s1,CN(C)c1ccncc1,ClCCl,,Cl,Cl,val
US20080227770A1,CCOC(=O)CCc1nnc(C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)COC(C)=O)C2=O)o1>>COc1cccc([C@H]2O[C@H](Cc3nnc(C(C)C(=O)O)o3)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,CCO,,[Na+].[OH-],,val
US20120115843A1,NCC(F)(F)F.O=C(Cl)c1cnc(Cl)nc1Cl>>O=C(NCC(F)(F)F)c1cnc(Cl)nc1Cl,,ClCCl,,CCN(CC)CC,,val
US20090156600A1,Cc1nc2c(Cl)ccc(O)c2c(C)c1Cc1ccc(Cl)cc1.N#CCBr>>Cc1nc2c(Cl)ccc(OCC#N)c2c(C)c1Cc1ccc(Cl)cc1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06616846B2,C=C(C)C(=O)[O-].C=C(C)C(=O)[O-].C=CC(=O)NCCNC(=O)C=C.[Zn+2]>>C=C(C)C(=O)[O-].C=C(C)C(=O)[O-].C=CC(=O)NCCNC(=O)C=C.[Zn+2],,CO,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20090233902A1,COC(=O)C(C)(N)Cc1c[nH]c2ccc(OC)cc12.O=Cc1cccc(O)c1>>COC(=O)C1(C)Cc2c([nH]c3ccc(OC)cc23)C(c2cccc(O)c2)N1,,CO,,ClCCl,,val
US20040157849A1,Cn1ncc2c(N)cccc21.O=C=NCc1ccc(Cl)c(Cl)c1>>Cn1ncc2c(NC(=O)NCc3ccc(Cl)c(Cl)c3)cccc21,,Cc1ccccc1,,,,val
US20110312969A1,CCOC(=O)c1cccc(O)c1.ClCCCBr>>CCOC(=O)c1cccc(OCCCCl)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080161573A1,CCOC(=O)C(=Cc1ccccc1Br)NC=O.O=C1CCC(=O)N1Br>>CCOC(=O)C(NC=O)=C(Br)c1ccccc1Br,,ClCCl,,CCN(CC)CC,,val
US20110172245A1,Cc1ccc(NC(=O)c2cccc(C3(C#N)CC3)c2)cc1Oc1ccc2nc(N)sc2c1.O=C(Cl)C1CC1>>Cc1ccc(NC(=O)c2cccc(C3(C#N)CC3)c2)cc1Oc1ccc2nc(NC(=O)C3CC3)sc2c1,CN(C)c1ccncc1,,,,,val
US04670434,CNC1CCCCC1.O=Cc1cc(OCCCC(=O)Cl)ccc1[N+](=O)[O-]>>CN(C(=O)CCCOc1ccc([N+](=O)[O-])c(C=O)c1)C1CCCCC1,,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20070238765A1,Cc1ccc(S(=O)(=O)CN=C=O)cc1.Cn1nc2c(-c3ccc(Cl)cc3Cl)cccc2c1C=O>>Cn1nc2c(-c3ccc(Cl)cc3Cl)cccc2c1-c1cnco1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20110294812A1,CCOC(=O)Cc1ccnc(NC(=O)OC(C)(C)C)c1.[Li]C>>CC(=O)Cc1ccnc(NC(=O)OC(C)(C)C)c1,,C1CCOC1,,CC(C)O,,val
US20160221946A1,CN(Cc1cn(S(=O)(=O)c2cccnc2)c2cc(Br)ccc12)C(=O)OC(C)(C)C>>CN(Cc1c[nH]c2cc(Br)ccc12)C(=O)OC(C)(C)C,,O,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20090124649A1,BrCc1ccccc1.CC(C)(C)OC(=O)N1CC=C(c2cccc(O)c2)CC1>>CC(C)(C)OC(=O)N1CC=C(c2cccc(OCc3ccccc3)c2)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20120053173A1,CON(C)C(=O)C1CCCCC1.COc1ccc2ncn(C)c2c1>>COc1ccc2nc(C(=O)C3CCCCC3)n(C)c2c1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20100130495A1,C=O.Cc1nccn1-c1ccc(Nc2nc3c(c(N(CCC#N)C4CC4)n2)CNCC3)cc1>>Cc1nccn1-c1ccc(Nc2nc3c(c(N(CCC#N)C4CC4)n2)CN(C)CC3)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20090042925A1,CCO.Cc1c(C)n2nnnc2c2nc(CON3C(=O)c4ccccc4C3=O)n(CCCCNC(=O)c3ccccc3)c12>>CC=NOCc1nc2c(c(C)c(C)n3nnnc23)n1CCCCNC(=O)c1ccccc1,,CCO,,NN,,val
US20110059940A1,CCNC(=O)c1ccc(CCl)cc1.NC(=O)C(NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1C(F)(F)F>>CCNC(=O)c1ccc(CN(C(C(N)=O)c2ccccc2C(F)(F)F)S(=O)(=O)c2ccc(Cl)cc2)cc1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110076292A1,O=C(O)Nc1nc(-c2cn3c(n2)-c2ccc(-c4ccc(Cl)cc4)cc2OCC3)n(-c2ccccc2Cl)n1>>Nc1nc(-c2cn3c(n2)-c2ccc(-c4ccc(Cl)cc4)cc2OCC3)n(-c2ccccc2Cl)n1,,CCOC(C)=O,,Cl,,val
US20110152310A1,COc1cc(CCN=C=S)cc(OC)c1>>COc1cc2c(c(OC)c1)C(=S)NCC2,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20050085508A1,COC(=O)c1ccccc1OCCC1(CCN2CCC(N(C(=O)c3ccco3)c3ccc(C)cc3)CC2)CCCCC1>>Cc1ccc(N(C(=O)c2ccco2)C2CCN(CCC3(CCOc4ccccc4C(=O)O)CCCCC3)CC2)cc1,,CO,O,Cl,[Na+].[OH-],val
US05811432,CCOC(=O)c1cccs1.O=C1Cc2cc(Sc3ccccc3)ncc2N1>>O=C1Nc2cnc(Sc3ccccc3)cc2C1C(=O)c1cccs1,,CCO,,Cl,[Na],val
US20090197871A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2cc(Cl)cc(-c3cccc(C=O)c3)c2)c1.O=C(O)C(F)(F)F>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2cc(Cl)cc(-c3cccc(CN4C[C@@H]5C[C@H]4CN5)c3)c2)c1.O=C(O)C(F)(F)F,,ClCCCl,,CC(=O)O,,val
US20030087957A1,CC(C)(C)NO.O=Cc1ccc(OCc2ccccc2)cc1>>CC(C)(C)[N+]([O-])=Cc1ccccc1OCc1ccccc1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20080039457A1,NNc1ncc(-c2ccc(Br)cc2)nn1.O=C(O)C1(c2ccc3ncsc3c2)CC1>>Brc1ccc(-c2cnc3nnc(C4(c5ccc6ncsc6c5)CC4)n3n2)cc1,,O=P(Cl)(Cl)Cl,,,,val
US20040082639A1,C1CCNC1.COc1cc2c(cc1OCC1CO1)CCC2=O>>COc1cc2c(cc1OCC(O)CN1CCCC1)CCC2=O,,COCCOC,,CCOC(C)=O,,val
US20160108037A1,COCc1nnc2c(C(=O)OC)ccc(C(F)(F)F)n12>>COCc1nnc2c(C(=O)O)ccc(C(F)(F)F)n12,,CCO,,Cl,[Na+].[OH-],val
US20150257385A1,N#CCc1ccc(Oc2ccc(Cl)cc2)nc1>>NCCc1ccc(Oc2ccc(Cl)cc2)nc1,[Ni],CCO,,N,[H][H],val
US20120022056A1,Cc1ccc2c(C3=CC(C)N(C(=O)OC(C)(C)C)CC3)cccc2n1>>Cc1ccc2c(C3CCN(C(=O)OC(C)(C)C)C(C)C3)cccc2n1,[Pd],CCO,,,,val
US20090239848A1,Clc1ccccn1.OCc1ccccc1>>c1ccc(COc2ccccn2)cc1,,Cc1ccccc1,,[K+].[OH-],,val
US20120289496A1,CC(C)C(=O)Cl.Nc1ccc(Br)cc1F>>CC(C)C(=O)Nc1ccc(Br)cc1F,,ClCCl,,CCN(CC)CC,,val
US04298537,CC(=O)O[C@@H]1CC[C@@]2(C)[C@H](CC[C@H]3[C@@H]4CC[C@H]([C@H](C)CCC(=O)O)[C@@]4(C)CC[C@@H]32)C1.O=S(Cl)Cl>>CC(=O)O[C@@H]1CC[C@@]2(C)[C@H](CC[C@H]3[C@@H]4CC[C@H]([C@H](C)CCCCl)[C@@]4(C)CC[C@@H]32)C1,,c1ccccc1,,,,val
US20040259910A1,C1COCCN1.CCOC(=O)c1cnc(C(=O)c2cccc(OCC(=O)O)c2)c2cc(OC)c(OC)cc12>>COc1cc2c(C(=O)O)cnc(C(=O)c3cccc(OCC(=O)N4CCOCC4)c3)c2cc1OC,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120046267A1,CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(C5=CCCC5)cc34)cn2)CC1>>CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(C5CCCC5)cc34)cn2)CC1,[Pd],C1CCOC1,,,,val
US20040132727A1,COc1cc2ncnc(Cl)c2cc1OC.Nc1ccc(O)cc1[N+](=O)[O-]>>COc1cc2ncnc(Oc3ccc(N)c([N+](=O)[O-])c3)c2cc1OC,,O,,CS(C)=O,[H-].[Na+],val
US20140274933A1,COc1ccc2c(-c3cccc(F)c3)nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1>>Cc1nc2ccc(N(C)C(=O)Cn3nc(-c4cccc(F)c4)c4ccc(O)cc4c3=O)cc2o1,,ClCCl,O,BrB(Br)Br,O=C([O-])O.[Na+],val
US20160255837A1,CC1Cc2c(Br)ccc(C(=O)O)c2S1(=O)=O.CNc1ncc(C(F)(F)F)cc1N>>CNc1ncc(C(F)(F)F)cc1NC(=O)c1ccc(Br)c2c1S(=O)(=O)C(C)C2,CN(C)C=O,ClCCl,ClCCl,CCN(CC)CC,,val
US03961056,CI.S=C(Nc1ccccc1)Nc1ccccc1>>CSC(=Nc1ccccc1)Nc1ccccc1.I,,CCO,,,,val
US20150315198A1,CCOC(=O)C=[N+]=[N-].O=C1CCCCC1>>CCOC(=O)c1n[nH]c2c1CCCC2,,CS(C)=O,O,C1CCNC1,,val
US20060116400A1,CN(C)C=O.O=C1O[C@@H](Cn2ccnn2)CN1c1ccc(-c2ccc(C3=NOC(CO)C3)[n+]([O-])c2)c(F)c1.c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd-4]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CN1CCC(O)(C2CC(c3ccc(-c4ccc(N5C[C@H](Cn6ccnn6)OC5=O)cc4F)cn3)=NO2)CC1,c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd-4]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100105665A1,C1CCNCC1.O=C(Br)c1cccc(CBr)c1>>O=C(c1cccc(CBr)c1)N1CCCCC1,,c1ccccc1,,,,val
US04137315,CCOc1ncc(C(=O)O)c2ccccc12.O=[N+]([O-])[O-]>>CCOc1ncc(C(=O)O)c2c([N+](=O)[O-])cccc12,,O=S(=O)(O)O,,O,,val
US20060154960A1,CC(=O)c1ccc(OC(F)F)c(O)c1.COC(OC)N(C)C>>COc1cc(C(=O)/C=C/N(C)C)ccc1OC(F)F,,O,,CN(C)C=O,,val
US04111933,CC(Br)(Br)CO.O=C(Cl)Cl>>CC(Br)(Br)COC(=O)Cl,,ClCCl,,c1ccncc1,,val
US05367081,C/C(N)=C\C#N.CC(=O)C(=Cc1cccc([N+](=O)[O-])c1)C(=O)NCC(=O)OC(C)(C)C>>CC1=C(C#N)C(c2cccc([N+](=O)[O-])c2)C(C(=O)NCC(=O)OC(C)(C)C)=C(C)N1,,Cc1ccccc1,,,,val
US20090088457A1,Cc1cc(Cl)c(O[C@H]2CCN(c3ccc(C=O)cn3)C2)c(Cl)c1.N#CCC(=O)O>>Cc1cc(Cl)c(O[C@H]2CCN(c3ccc(/C=C(\C#N)C(=O)O)cn3)C2)c(Cl)c1,,Cc1ccccc1,,C1CCNCC1,,val
US20110237565A1,CC(C)(C)OC(=O)N1CCN(c2ncc(Br)nc2N)CC1.CCOC(=O)C(=O)CBr>>Br.CCOC(=O)c1cn2c(Br)cnc(N3CCNCC3)c2n1,,CCO,,,,val
US20090023725A1,CC(C)(C)OC(=O)NN=C(c1ccc(N2CCOCC2)nc1)c1ccc(Br)cc1F>>Brc1ccc2c(-c3ccc(N4CCOCC4)nc3)n[nH]c2c1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2cc(Cl)c(O[C@@H]3CC[C@H](O)C[C@H]3c3ccnn3C)cc2F)c(OC)c1>>Cn1nccc1[C@@H]1C[C@@H](O)CC[C@H]1Oc1cc(F)c(S(=O)(=O)Nc2ccncn2)cc1Cl,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20110183938A1,CC(C)(C)OC(=O)N[C@H]1CCN(c2ccnc3c2c2cc(C#N)ncc2n3COCC[Si](C)(C)C)C1>>C[Si](C)(C)CCOCn1c2cnc(C#N)cc2c2c(N3CC[C@H](N)C3)ccnc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030225057A1,COc1cc2c(cc1Br)C(C)CN(C(=O)C(F)(F)F)CC2>>CC1CN(C(=O)C(F)(F)F)CCc2cc(O)c(Br)cc21,,ClCCl,ClCCl,BrB(Br)Br,,val
US04788206,CC(C)(N)CCCc1cccnc1.O=C(/C=C/C=C(c1cccc(F)c1)c1cccc(F)c1)Oc1ccc([N+](=O)[O-])cc1>>CC(C)(CCCc1cccnc1)NC(=O)/C=C/C=C(c1cccc(F)c1)c1cccc(F)c1,,C1CCOC1,,,,val
US20160194302A1,CC(=O)OC(C)=O.CNC1CCN(C(=O)CCc2nccn2C)CC1>>CC(=O)N(C)C1CCN(C(=O)CCc2nccn2C)CC1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20110021496A1,Clc1nc(N2CCOCC2)c2sc(CBr)cc2n1.O=C(N1CC2CCC(C1)N2)C(F)(F)F>>O=C(N1CC2CCC(C1)N2Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1)C(F)(F)F,,C1CCOC1,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20020169314A1,CCCCCSc1nc2ccc(S(=O)(=O)N(Cc3ccccc3)[C@H](C)C(=O)O)cc2s1.O=C(Cl)C(=O)Cl>>CSc1nc2ccc(S(=O)(=O)N[C@@H](C(=O)Cl)C(C)C)cc2s1,,ClCCl,,CN(C)C=O,,val
US20090181928A1,CC(=O)Cl.CC(C)(C)OC(=O)[C@@H](N)Cc1ccc(N2CC(=O)N(CC[Si](C)(C)C)S2(=O)=O)c(OCc2ccccc2)c1>>CC(=O)N[C@@H](Cc1ccc(N2CC(=O)N(CC[Si](C)(C)C)S2(=O)=O)c(OCc2ccccc2)c1)C(=O)OC(C)(C)C,,ClCCl,O,CCN(CC)CC,Cl,val
US20160039757A1,Br[Mg]C1CCCCC1.O=C1CCN(C(=O)OCc2ccccc2)C1>>OC1(C2CCCCC2)CCNC1,,C1CCOC1,,CC(=O)O,,val
US20160161817A1,BrP(Br)Br.OCc1ccc(OCc2ccccc2)c(F)c1F>>Fc1c(CBr)ccc(OCc2ccccc2)c1F,,ClCCl,,,,val
US05889002,CC[C@@H](C)N.O=S1(=O)N=C(Cl)Nc2cc(Cl)sc21>>CC[C@@H](C)NC1=NS(=O)(=O)c2sc(Cl)cc2N1,,O,,,,val
US20070173530A1,Nc1ccc2cnccc2c1.O=C=NCc1ccccc1>>O=C(NCc1ccccc1)Nc1ccc2cnccc2c1,CN(C)c1ccncc1,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20070105865A1,CN1Cc2cc(N)ccc2C(C)(C)C1.OC1(Cl)NC=Nc2cc(-c3ncccc3C(F)(F)F)ccc21>>CN1Cc2cc(Nc3ncnc4cc(-c5ncccc5C(F)(F)F)ccc34)ccc2C(C)(C)C1.Cl,,CC(C)O,,,,val
US20060167058A1,COC(=O)c1cccc(OCCCCN)c1.Clc1nc2ccccc2o1>>COC(=O)c1cccc(OCCCCNc2nc3ccccc3o2)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,O,val
US20050203091A1,NN.O=C(c1ccccc1Cl)c1ccc(Cl)nc1Cl>>Clc1ccc2c(-c3ccccc3Cl)n[nH]c2n1,,C1CCOC1,CCO,CCN(C(C)C)C(C)C,,val
US20130143843A1,CC(=O)c1ccc(C)cc1.CC(C)(C)[S@](=O)/N=C(\c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F>>Cc1ccc(C(=O)C[C@](N[S@@](=O)C(C)(C)C)(c2ccc(OCCCCCC(F)(F)F)cc2)C(F)(F)F)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20090312319A1,Cc1cccc2cc([C@H](C)N)n(C3CC3)c(=O)c12.Cc1cccc2cc([C@H](C)Nc3ncnc4c3ncn4C3CCCCO3)n(C3CC3)c(=O)c12.Clc1ncnc2c1ncn2C1CCCCO1>>Cc1cccc2cc([C@H](C)Nc3ncnc4[nH]cnc34)n(C3CC3)c(=O)c12.Cc1cccc2cc([C@H](C)Nc3ncnc4c3ncn4C3CCCCO3)n(C3CC3)c(=O)c12,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20090149439A1,C=O.Cc1cc(C(N)=O)ncc1C(c1c(F)ccc(F)c1F)S(=O)(=O)c1ccc(F)cc1>>Cc1cc(C(=O)NCO)ncc1C(c1c(F)ccc(F)c1F)S(=O)(=O)c1ccc(F)cc1,,COCCOC,,[Na+].[OH-],,val
US05070082,CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=CCS[C@H]12)c1csc(N)n1>>CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=CCS[C@H]12)c1csc(N)n1,,O,,CC(=O)O,,val
US20160075720A1,CC(C)(C)N.Nc1nc(F)cc(F)n1>>CC(C)(C)Nc1cc(F)nc(N)n1,,C1COCCO1,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20070010670A1,O=C(Cl)c1cc(Cl)c(OCc2ccccc2)c(Cl)c1.c1ccc2c(c1)NCCO2>>O=C(c1cc(Cl)c(OCc2ccccc2)c(Cl)c1)N1CCOc2ccccc21,,ClC(Cl)Cl,,CCN(CC)CC,,val
US09266853B2,CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCC(=O)CCCCCCC)[C@@](O)(CC(=O)[O-])C(=O)OC(C)(C)C)C(=O)OCC(=O)c2ccccc2)cc1.O=C(CBr)c1ccccc1>>CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCC(=O)CCCCCCC)[C@@](O)(CC(=O)OCC(=O)c2ccccc2)C(=O)OC(C)(C)C)C(=O)OCC(=O)c2ccccc2)cc1,,CCOC(C)=O,,CCN(CC)CC,,val
US05700796,O=C(Cl)c1ccc(NC(=O)c2ccccc2-c2ccccn2)cc1Br.c1ccc2c(c1)Cn1cccc1CN2>>O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Br)c1)c1ccccc1-c1ccccn1,,ClCCl,,CCN(CC)CC,O,val
US20040235905A1,O=C1c2ccc(O)cc2CCC1c1ccccc1>>Oc1ccc2c(c1)CCC(c1ccccc1)C2,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20070099956A1,Cc1cccc(Cl)c1C=O>>Cc1cccc(Cl)c1CO,,CO,,[BH4-].[Na+],,val
US05194617,CCCCCCC#CC(O)c1nc2ccc(F)cc2c(OC(C)=O)c1C>>CCCCCCC#CC(O)C1=Nc2ccc(F)cc2C(=O)C1C,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US20030040533A1,COC(=O)C(Cc1ccc(OCCn2c(=O)sc3ccccc32)cc1)C(=O)OC>>COC(=O)C(Cc1ccc(OCCn2c(=O)sc3ccccc32)cc1)C(=O)O,,CO,,[K+].[OH-],,val
US20140221311A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Nc1nnc(-c2ccc(Br)cc2F)s1>>CC1(C)OB(c2ccc(-c3nnc(N)s3)c(F)c2)OC1(C)C,,C1COCCO1,,ClCCl,CC(=O)[O-].[K+],val
US20100197655A1,CC(C)(C)OC(=O)N(c1cscn1)S(=O)(=O)c1ccc(F)c(C#N)c1.Oc1ccc(Cl)cc1I>>CC(C)(C)OC(=O)N(c1cscn1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2I)c(C#N)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20130023541A1,CCN(Cc1ccc(CBr)cc1)[C@@H]1CCN(C(=O)C(C)C)C1.CCN[C@@H]1CCN(c2ncccc2C(=O)OC(C)C)C1>>CCN(Cc1ccc(CN(CC)[C@@H]2CCN(c3ncccc3C(=O)OC(C)C)C2)cc1)[C@@H]1CCN(C(=O)C(C)C)C1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080287475A1,COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)n[nH]1.Cc1cc(Nc2nc(Cl)nc(N(C)S(C)(=O)=O)c2F)n[nH]1>>Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N(C)S(C)(=O)=O)c2F)n[nH]1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20090137548A1,CCc1sc(-c2ccc(C(=O)OC)cc2C)nc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C>>CCc1sc(-c2ccc(C(=O)O)cc2C)nc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C,,C1COCCO1,O,Cl,[Li+].[OH-],val
US20090143353A1,COc1c(N)c(C(=O)O)c(C)c(I)c1F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1c(F)c(I)c(C)c2c(=O)oc(=O)[nH]c12,,C1CCOC1,,,,val
US05362742,CC(C)(C)c1cc(C(=O)O)cc(C(C)(C)C)c1O.COc1ccc(-c2c(N)cnc3ccc(Cl)cc23)c(OC)c1OC>>COc1ccc(-c2c(NC(=O)c3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)cnc3ccc(Cl)cc23)c(OC)c1OC,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130096113A1,CSc1nc2ccc(Cn3cnc4cc(F)cnc43)cc2s1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc2ccc(Cn3cnc4cc(F)cnc43)cc2s1,,ClCCl,,O=C([O-])O.[Na+],,val
US08293729B2,CC(C)(C)OC(=O)N1CCC(ON=C2CCN(c3ccc(S(C)(=O)=O)cc3F)CC2)CC1>>CS(=O)(=O)c1ccc(N2CCC(=NOC3CCNCC3)CC2)c(F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140275047A1,Cc1ccc(C(C)C)c(N2C(=O)CS/C2=N\C(=O)Oc2ccc([N+](=O)[O-])cc2)c1.NC1CCCCC1c1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1>>Cc1ccc(C(C)C)c(N2C(=O)CS/C2=N\C(=O)NC2CCCCC2c2ccc(-c3ncn(-c4ccc(OC(F)(F)F)cc4)n3)cc2)c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140023611A1,CCN(CC)CCNC.O=C(O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1>>CCN(CC)CCN(C)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20140323475A1,COCCOCCl.O=Cc1cc(Cl)ccc1O>>COCCOCOc1ccc(Cl)cc1C=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05981572,C[N+]1([O-])CCOCC1.Clc1ccc(CBr)c2ccoc12>>O=Cc1ccc(Cl)c2occc12,,CC#N,,,,val
US20150299198A1,CO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1N.O=C(O)c1ccc(-n2cnnn2)nc1>>COC1CN(C(=O)OC(C)(C)C)CCC1NC(=O)c1ccc(-n2cnnn2)nc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20090264496A1,CCCCCCCCCCCCCCCCCCN=C=O.NCCc1c[nH]c2ccc(O)cc12>>CCCCCCCCCCCCCCCCCCNC(=O)NCCc1c[nH]c2ccc(O)cc12,,c1ccncc1,,Cl,O,val
US20020173527A1,COC(=O)c1ccc(OC)cc1O.O=[N+]([O-])O>>COC(=O)c1ccc(OC)c([N+](=O)[O-])c1O,,CC(=O)O,,O,,val
US20090298815A1,CC(C)c1nc(-c2ccc(F)c(NS(=O)(=O)c3cc(F)ccc3F)c2)c(-c2ccnc(Cl)n2)s1.CS(=O)(=O)N1CCC(N)CC1>>CC(C)c1nc(-c2ccc(F)c(NS(=O)(=O)c3cc(F)ccc3F)c2)c(-c2ccnc(NC3CCN(S(C)(=O)=O)CC3)n2)s1,,C1CCOC1,,,,val
US05212164,CC(C)=CCCC(C)=CCCC(C)=CCBr.O=C1NC(=O)c2ccccc21>>CC(C)=CCCC(C)=CCCC(C)=CCN1C(=O)c2ccccc2C1=O,,CN(C)C=O,,[K],,val
US20060052396A1,C1CNCCN1.CC(=O)Nc1ccc(S(=O)(=O)F)cc1F.CCN(CC)CC>>CC(=O)Nc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1F,,C1CCOC1,,,,val
US20150368210A1,COC(=O)Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.Nc1ncc(Br)nc1NCc1c(Cl)cccc1Cl>>Nc1ncc(-c2cnn(CC(=O)O)c2)nc1NCc1c(Cl)cccc1Cl,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20070208007A1,CCCN(CCC)CCCCNCc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1.N#CBr>>CCCN(CCC)CCCCN(C#N)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20050277685A1,C=CCOc1cc(OC)ccc1C(=O)OC>>C=CCOc1cc(OC)ccc1C(=O)O,,CCOC(C)=O,CO,[K+].[OH-],,val
US20120028961A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.[N-]=[N+]=NCc1ccc(Br)c(F)c1>>CC(C)(C)OC(=O)NCc1ccc(Br)c(F)c1,[Pd],CCO,,,,val
US20050070539A1,C1CNCCN1.NS(=O)(=O)c1ccc(F)c(F)c1>>NS(=O)(=O)c1ccc(N2CCNCC2)c(F)c1,,O,,,,val
US20040132727A1,CC(O)c1cc(F)c(F)cc1F.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)OC(C)c4cc(F)c(F)cc4F)c(C)c3C)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US20160194315A1,COC(=O)c1ccnc2cc(Cc3ccc(F)cc3)[nH]c12>>O=C(O)c1ccnc2cc(Cc3ccc(F)cc3)[nH]c12,,CC#N,O,,,val
US20140121200A1,C[Sn](C)(C)[Sn](C)(C)C.OC1CCN(c2ccc(Br)cc2)CC1>>C[Sn](C)(C)c1ccc(N2CCC(O)CC2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20140357666A1,CCCCN(CCCC)C(=O)c1cc(C)n(-c2ccc(N)cc2C(=O)N2Cc3ccccc3C[C@H]2CO[Si](C)(C)C(C)(C)C)n1.O=C=NCc1ccccc1>>CCCCN(CCCC)C(=O)c1cc(C)n(-c2ccc(NC(=O)NCc3ccccc3)cc2C(=O)N2Cc3ccccc3C[C@H]2CO[Si](C)(C)C(C)(C)C)n1,,ClCCl,O,CCN(CC)CC,,val
US04275077,Nc1ccc(Oc2cccc3ccccc23)cc1.O=C=NC(=O)c1ccccc1Cl>>O=C(NC(=O)c1ccccc1Cl)Nc1ccc(Oc2cccc3ccccc23)cc1,,Cc1ccccc1,,,,val
US20020147200A1,Clc1cncc(Cl)n1.OCCn1ccc2ccccc21>>Clc1cncc(OCCn2ccc3ccccc32)n1,,C1COCCO1,ClCCl,,,val
US20150232435A1,NCCCCN1CCN(c2ccnc3cc(Cl)ccc23)CC1.O=C(O)c1cn2ccccc2n1>>O=C(NCCCCN1CCN(c2ccnc3cc(Cl)ccc23)CC1)c1cn2ccccc2n1,,CO,ClC(Cl)Cl,,,val
US04113731,Nc1c(-c2ccccc2)c(O)nn1-c1ccccc1.O=C=Nc1ccccc1>>O=c1[nH]c2c(c(O)nn2-c2ccccc2)c2ccccc12,,CCOC(C)=O,,,,val
US04255434,CC(C)(CCl)C(=O)CBr.Oc1ccc(-c2ccc(Cl)cc2)cc1>>CC(C)(CCl)C(=O)COc1ccc(-c2ccc(Cl)cc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04853408,CC(=O)c1ccccc1OCCNC(C)(C)C.O=Cc1cccc2[nH]ccc12>>CC(C)(C)NCCOc1ccccc1C(=O)C=Cc1cccc2[nH]ccc12,,CCO,O,[Na+].[OH-],,val
US20040063754A1,C[C@@H](c1ccccc1)N1CC[C@H](C2(N(C)C(=O)OC(C)(C)C)CC2)C1=O>>C[C@@H](c1ccccc1)N1CC[C@@H](C2(N(C)C(=O)OC(C)(C)C)CC2)C1,,C1CCOC1,,O,O=C([O-])[O-].[K+].[K+],val
US20080269277A1,CCOC(=O)c1cc2cc(Cl)ncc2[nH]1>>O=C(O)c1cc2cc(Cl)ncc2[nH]1,,CCO,,[Na+].[OH-],,val
US04294606,Cc1cc(C)c(N2CCC2=O)cc1N.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(C)c(N2CCC2=O)cc1NS(=O)(=O)C(F)(F)F,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20020016368A1,O=C(O)CCc1ccc2c(c1)OCO2>>OCCCc1ccc2c(c1)OCO2,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US03962288,C=CCCC1C=CCC2=C1C(=O)c1ccccc1C2=O>>CCCCC1CCCC2=C1C(=O)c1ccccc1C2=O,[Pd],CCOC(C)=O,,[H][H],,val
US20160222005A1,CC(C)(C)OC(=O)N1CC=C(c2ccc([N+](=O)[O-])c(N)n2)CC1>>CC(C)(C)OC(=O)N1CCC(c2ccc(N)c(N)n2)CC1,[Pd],CCO,,CCOC(C)=O,,val
US05624935,Cn1c(CO)nc2cncnc21.O=C1SC(Cc2ccc(O)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1>>Cn1c(COc2ccc(CC3SC(=O)N(C(c4ccccc4)(c4ccccc4)c4ccccc4)C3=O)cc2)nc2cncnc21,,c1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20150175623A1,CC(C)[Si](OCCN1CCN(C(=O)C(F)(F)F)CC1)(C(C)C)C(C)C>>CC(C)[Si](OCCN1CCN(CC(F)(F)F)CC1)(C(C)C)C(C)C,,C1CCOC1,,CO,,val
US20080262040A1,NC(=O)c1cc(-c2ccccc2)cc2c1cnn2C1CCCNC1.O=S(=O)(Cl)c1ccc(F)cc1>>NC(=O)c1cc(-c2ccccc2)cc2c1cnn2C1CCCN(S(=O)(=O)c2ccc(F)cc2)C1,CN(C)c1ccncc1,,,CCN(CC)CC,,val
US20160221945A1,CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)c(C(=O)O)cn1.[NH4+]>>CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)c(C(N)=O)cn1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04282242,CCOC(=O)c1c[nH]c(C(=O)c2ccc(-c3ccccc3)cc2)c1>>O=C(O)c1c[nH]c(C(=O)c2ccc(-c3ccccc3)cc2)c1,,CO,,,,val
US20140275065A1,CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1[C@H](Nc1cnc(C(F)(F)F)cn1)C2>>FC(F)(F)c1cnc(N[C@@H]2C[C@H]3CC[C@@H]2N3)cn1,,C1COCCO1,CCOC(C)=O,Cl,,val
US04882083,CCCCCCCCc1ccc(C(=N)N)cc1.COC(=O)C(OC)C(=O)OC>>CCCCCCCCc1ccc(-c2nc(O)c(OC)c(O)n2)cc1,,CC(=O)O,,Cl,,val
US06586441B2,CS(=O)c1nc(N)nc(-c2ccco2)c1C#N.Cc1cccc(CN)c1>>Cc1cccc(CNc2nc(N)nc(-c3ccco3)c2C#N)c1,,COCCOC,,,,val
US20050070592A1,CCCCCc1c(-c2ccccc2)[nH]c2ccc(Br)cc12.CI>>CCCCCc1c(-c2ccccc2)n(C)c2ccc(Br)cc12,,CN(C)C=O,,,,val
US04279982,NNC(=O)c1cccc2ccccc12.O=C(C(Cl)(Cl)Cl)C(Cl)(Cl)Cl>>O=C(NNC(=O)C(Cl)(Cl)Cl)c1cccc2ccccc12,,CC#N,,,,val
US20160221994A1,CC(C)(C)OC(=O)Nc1ccc(CNC(=O)/C=C/C2Cc3cc(-c4cccc(S(=O)(=O)N5CCOCC5)c4)cc(Cl)c3O2)cn1>>Nc1ccc(CNC(=O)/C=C/C2Cc3cc(-c4cccc(S(=O)(=O)N5CCOCC5)c4)cc(Cl)c3O2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080300242A1,CCOc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)c(CC)cc1N.CCOc1ccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)cc1C(=O)Nc1c(F)cccc1F>>CCOc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)c(CC)cc1Nc1nccc(-c2c(-c3ccc(OCC)c(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1,,OCC(F)(F)F,,Cl,,val
US20140221349A1,COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CN3CCNCC3)ccc21.COC(=O)Cl>>COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CN3CCN(C(=O)OC)CC3)ccc21,,ClCCl,,CCN(CC)CC,,val
US20100136142A1,N#Cc1ccc(C=O)c(O)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>N#Cc1ccc(C=O)c(OS(=O)(=O)C(F)(F)F)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120329732A1,BrCCCc1ccccc1.O=C(O)c1cc(Br)ccc1Cl>>O=C(c1ccc(CCCBr)cc1)c1cc(Br)ccc1Cl,,ClCCl,ClCCl,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US03945998,CC1=NC(C)(COCc2ccccc2)CO1>>CC(N)(CO)COCc1ccccc1,,CCO,,O,[K+].[OH-],val
US20040067202A1,CCOC(=O)CBr.OCCOCCOCCOCCOCCOCCOCCOCCOCCOCC(F)(F)F>>O=C(O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCC(F)(F)F,,C1CCOC1,CCO,[Na+].[OH-],,val
US20140073651A1,C[Si](C)(C)CCOCCl.Oc1cccc(Cl)n1>>C[Si](C)(C)CCOCOc1cccc(Cl)n1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100190828A1,CN(N)c1ccc(C(F)(F)F)cn1.Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C=O)cs2)CC1>>Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C=NN(C)c3ccc(C(F)(F)F)cn3)cs2)CC1,,CCO,,,,val
US20080234237A1,O=C1CCc2cc([N+](=O)[O-])ccc2N1CCCN1CCCCC1>>Nc1ccc2c(c1)CCC(=O)N2CCCN1CCCCC1,[Ni],CO,,NN,O,val
US05929097,COC(=O)c1cc(C=CC(=O)OC(C)(C)C)cc(C)c1N(C)S(=O)(=O)c1ccc(OC)cc1>>COC(=O)c1cc(CCC(=O)OC(C)(C)C)cc(C)c1N(C)S(=O)(=O)c1ccc(OC)cc1,[Pd],CCO,,,,val
US20060100161A1,CC(C)(C)C(=O)Cl.Cc1ccc(Cl)cc1C(=O)NN=C(CCCN=[N+]=[N-])c1ccccc1>>Cc1ccc(Cl)cc1C1=NN(C(=O)C(C)(C)C)C(CCCN=[N+]=[N-])(c2ccccc2)O1,,c1ccncc1,,O,,val
US20070129341A1,CCOC(=O)C(Cc1ccc(N)nc1)c1c[nH]cn1.O=C1C(Br)CCN1c1ccccc1>>CCOC(=O)C(Cc1ccc(N)nc1)c1cn(C2CCN(c3ccccc3)C2=O)cn1,,CN(C)C=O,,O,[H-].[Na+],val
US20100137417A1,COC(=O)CCNC(=O)c1ccc(C(Oc2cc(C)c(-c3ccc(C(F)(F)F)cc3)c(C)c2)C(C)C)s1>>CCC(Oc1cc(C)c(-c2ccc(C(F)(F)F)cc2)c(C)c1)c1ccc(C(=O)NCCC(=O)O)s1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20160106842A1,COC(=O)CCCCOc1cc(C=O)cc(OCCCCC(=O)OC)c1>>O=Cc1cc(OCCCCC(=O)O)cc(OCCCCC(=O)O)c1,,CCO,CCOC(C)=O,O,[K+].[OH-],val
US20040157909A1,O=C1Cc2c(cccc2-c2cccc(F)c2)N1.O=Cc1cc2c([nH]1)CCCC2CCN1CCCC1>>O=C1Nc2cccc(-c3cccc(F)c3)c2/C1=C/c1cc2c([nH]1)CCCC2CCN1CCCC1,C1CCNCC1,CCO,,,,val
US20030037701A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=c1[nH]c2ccc3c(c2[nH]1)OC(CO)CC3>>Cc1ccc(S(=O)(=O)OCC2CCc3ccc4[nH]c(=O)[nH]c4c3O2)cc1,,c1ccncc1,,,,val
US20110306592A1,CC(C)(C)NC(=O)n1nc(N2C(=O)c3ccccc3C2=O)c2cc(C(F)(F)F)ccc21>>CC(C)(C)NC(=O)n1nc(N)c2cc(C(F)(F)F)ccc21,,C1CCOC1,,NN,,val
US20140018533A1,CCOC(=O)C1=C(N2CCS(=O)(=O)CC2)OCC1=O.O=Cc1c[nH]c2ncccc12>>CCOC(=O)C1=C(N2CCS(=O)(=O)CC2)OC(=Cc2c[nH]c3ncccc23)C1=O,,CCO,,C1CCNCC1,,val
US20060074075A1,O=[N+]([O-])c1ccc2c(c1)C(O)CCC2>>Nc1ccc2c(c1)C(O)CCC2,,CO,,,,val
US05599811,COC(=O)CNS(=O)(=O)c1cc(OC)c(OC)cc1C(=O)OC>>COC(=O)C1=C(O)c2cc(OC)c(OC)cc2S(=O)(=O)N1,,CN(C)C=O,Cl,C[O-].[Na+],,val
US20030018200A1,Cc1c(Br)ccc(N)c1C1=NOCC1.Cl.O=S=O>>Cc1c(Br)ccc(S(=O)(=O)Cl)c1C1=NOCC1,Cl[Cu]Cl,CC(=O)O,O,O=N[O-].[Na+],,val
US20120214762A1,CN(C)C(=O)c1nn(-c2ccnc(N)n2)c2cc(C#C[Si](C)(C)C)ccc12>>C#Cc1ccc2c(C(=O)N(C)C)nn(-c3ccnc(N)n3)c2c1,,CO,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20080312226A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(Nc1cccnc1)OCC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1CCN(C(=O)Nc2cccnc2)CC1,,O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20030096803A1,C=C[Sn](CCCC)(CCCC)CCCC.CCOC(=O)C1(C(=O)OCC)CCCN1c1ccc(Oc2ccc(Br)cc2)nc1>>C=Cc1ccc(Oc2ccc(N3CCCC3(C(=O)OCC)C(=O)OCC)cn2)cc1,,Cc1ccccc1,,,,val
US05292957,CCCCOC(C)=O.O=[N+]([O-])c1ccc(Cl)c(Cl)c1>>CC(C)Nc1ccc(Cl)c(Cl)c1,[Pt],,,,,val
US20130209400A1,C[C@H](N)c1ccc(F)cn1.Clc1ccnc(-c2cnn3ccncc23)n1>>C[C@H](Nc1ccnc(-c2cnn3ccncc23)n1)c1ccc(F)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US06310095B1,COC[C@@H](N)Cc1ccccc1>>COC[C@@H](N)CC1CCCCC1,O=[Pt],CCO,,Cl,Cl,val
US05837720,COCCl.O[C@H]1CCN(Cc2ccccc2)C1>>COCO[C@H]1CCNC1,,C1CCOC1,O,[Na+].[OH-],,val
US06013662,COC(=O)C12CN(Cc3ccccc3)CC1C(I)=CCC2c1ccccc1.OB(O)c1ccsc1>>COC(=O)C12CN(Cc3ccccc3)CC1C(c1ccsc1)=CCC2c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20050203078A1,CCOC(=O)[C@H](CCC#N)NC(=O)OCc1ccccc1.[N-]=[N+]=[N-]>>CCOC(=O)[C@H](CCc1nnn[nH]1)NC(=O)OCc1ccccc1,,Cc1ccccc1,,CCN(CC)CC,Cl,val
US05935990,CC1(C)COC(CCC(=O)c2ccc(S(C)(=O)=O)cc2)OC1.Nc1ccc(F)cc1>>CS(=O)(=O)c1ccc(-c2cccn2-c2ccc(F)cc2)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120053173A1,Br[Mg]C1CCCCC1.CCc1nn(-c2cccc(OC)c2)cc1C=O>>CCc1nn(-c2cccc(OC)c2)cc1C(O)C1CCCCC1,,C1CCOC1,,,,val
US06413974B1,Clc1nc(Cl)c2ncn(C3CCCC3)c2n1.NCc1ccccc1Cl>>Clc1nc(NCc2ccccc2Cl)c2ncn(C3CCCC3)c2n1,,CCN(CC)CC,,,,val
US20060025438A1,O=C1CCc2ccccc21.O=C1c2ccccc2C(=O)N1CBr>>O=C1c2ccccc2CC1CN1C(=O)c2ccccc2C1=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US04895865,CCCCCCl.CCOc1ccccc1CC#N>>CCCCCC(C#N)c1ccccc1OCC,,CCOCC,CS(C)=O,O,[Na+].[OH-],val
US20140179664A1,CN.COC(=O)Cn1cc([N+](=O)[O-])cn1>>CNC(=O)Cn1cc([N+](=O)[O-])cn1,,CCO,,,,val
US05686482,COc1cc(NC(=O)C2CC2)ccc1C(=O)O.O=[N+]([O-])O>>COc1cc(NC(=O)C2CC2)c([N+](=O)[O-])cc1C(=O)O,,CC(=O)O,CC(=O)OC(C)=O,,,val
US03971772,NCCOC1CCCCO1.[N-]=C=O>>NC(=O)NCCOC1CCCCO1,,O,,Cl,,val
US20150259367A1,Nc1ccc(Cl)cc1N.O=C(O)CO>>OCc1nc2cc(Cl)ccc2[nH]1,,Cc1ccccc1C,,Cl,N,val
US20030153568A1,CCNC(=O)Nc1nc2ccc(Br)c(O)c2s1.CI>>CCNC(=O)Nc1nc2ccc(Br)c(OC)c2s1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120116075A1,Cc1ccc(C(=O)Cl)cc1[N+](=O)[O-].Nc1ccc(F)c(Cl)c1>>Cc1ccc(C(=O)Nc2ccc(F)c(Cl)c2)cc1[N+](=O)[O-],,ClCCl,,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20130065906A1,Clc1nsc(Cl)n1.O=C(c1ccc(-c2cnco2)cc1)N(C1CCNCC1)C1CC1>>O=C(c1ccc(-c2cnco2)cc1)N(C1CC1)C1CCN(c2nc(Cl)ns2)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US20080221149A1,CC(C)(C)OC(=O)Nc1ncc(Br)cc1F.CI>>CN(C(=O)OC(C)(C)C)c1ncc(Br)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US20100048570A1,CC(C)(CCI)C(=O)[O-].CC(C)C(Oc1ccc(CNC(=O)C2SCCN2C(=O)C[C@@H](Cc2cc(F)c(F)cc2F)NC(=O)OC(C)(C)C)cc1)C(=O)O>>CC(C)C(Oc1ccc(CNC(=O)C2SCCN2C(=O)C[C@@H](Cc2cc(F)c(F)cc2F)NC(=O)OC(C)(C)C)cc1)C(=O)OCOC(=O)C(C)(C)C,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20100069381A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.COC(=O)c1ccc2ncc(I)n2c1>>COC(=O)c1ccc2ncc(-c3ccccn3)n2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,Cc1ccccc1,,val
US20020040028A1,CC(=O)Cl.c1cnc2c(c1)CNCC2>>CC(=O)N1CCc2ncccc2C1,,ClCCl,,CCN(CC)CC,,val
US20150197512A1,CC(C)(C)CCCl.O=Cc1ccc(O)cc1>>CC(C)(C)CCOc1ccc(C=O)cc1,,CN(C)C=O,,[I-].[Na+],O=C([O-])[O-].[Cs+].[Cs+],val
US20090023917A1,COc1ccc2c(Cc3ccc(OCCN4CCCCC4)cc3)c(OS(=O)(=O)C(F)(F)F)ccc2c1.OB(O)c1cccc(F)c1>>COc1ccc2c(Cc3ccc(OCCN4CCCCC4)cc3)c(-c3cccc(F)c3)ccc2c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,[Cs+].[F-],,val
US20150224104A1,C1COCCN1.OCc1ccc(CCBr)cc1>>OCc1ccc(CCN2CCOCC2)cc1,,CC#N,,[I-].[Na+],,val
US20130059834A1,CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CC4CN(Cc5ccccc5)CCO4)c4ccc(OC(F)F)cc34)nc12>>CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CC4CN(Cc5ccccc5)CCO4)c4ccc(OC(F)F)cc34)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060223801A1,COc1nc(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)sc1C#N>>Cc1[nH]c(C(=O)NC2CCN(c3nc(O)c(C#N)s3)CC2)c(Cl)c1Cl,,ClC(Cl)Cl,ClCCl,C[Si](C)(C)I,,val
US04108667,C1=[NH+]CCc2ccccc21.CC(C)=C1Cc2ccccc2C1=O.[O-][Cl+3]([O-])([O-])[O-]>>Cc1cc2[n+](c3c1Cc1ccccc1-3)CCc1ccccc1-2.[O-][Cl+3]([O-])([O-])[O-],,CO,,,,val
US20070249670A1,COC(=O)[C@@H](NC(=O)c1nc(-c2ccc(OC)cc2)sc1NC(=O)Nc1c(C)cc(C)cc1C)C1CCCCC1>>COc1ccc(-c2nc(C(=O)N[C@H](C(=O)O)C3CCCCC3)c(NC(=O)Nc3c(C)cc(C)cc3C)s2)cc1,,C1COCCO1,O,Cl,[Li+].[OH-],val
US06235754B1,CC(C)C=O.CCOc1ccc(Br)cc1>>CCOc1ccc(C(O)C(C)C)cc1,,C1CCOC1,CCCCCC,Cl,[Li]CCCC,val
US06350749B1,CCO.CS(=O)(=O)O.Cc1ccnc2c1C(=NNC(=N)N)CC(c1cc(Cl)sc1Cl)C2>>CS(=O)(=O)O.Cc1ccnc2c1C(=NNC(=N)N)CC(c1cc(Cl)sc1Cl)C2.O,,CCO,,,,val
US20110152318A1,COc1cccc(C2(O)CCC2)c1>>COc1cccc(C2CCC2)c1,[Pd],CCO,CCOC(C)=O,[H][H],,val
US05036059,CC(=O)CP1(=O)OCCCO1.O=Cc1cccc([N+](=O)[O-])c1>>CC(=O)C(=Cc1cccc([N+](=O)[O-])c1)P1(=O)OCCCO1,,Cc1ccccc1,O,C1CCNCC1,CC(=O)O,val
US20120238569A1,CCc1cc(C(=O)NCc2cccc(O)c2)sc1C(=O)N[C@@H](CNC(=O)OC(C)(C)C)C(=O)OC.O=C(O)C(F)(F)F>>CCc1cc(C(=O)NCc2cccc(O)c2)sc1C(=O)N[C@@H](CN)C(=O)OC.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20080188531A1,Cc1nc(NC(=O)CCC(=O)OC(C)(C)C)sc1-c1csc(CC#N)n1>>Cc1nc(NC(=O)CCC(=O)O)sc1-c1csc(CC#N)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020151715A1,CC(=O)O.CCOC(=O)C[N+](=O)[O-].CCOC(OCC)OCC.Nc1cc(F)cc(C(F)(F)F)c1>>O=C(O)c1cn(-c2cc(F)cc(C(F)(F)F)c2)cn1,[Fe],,,,,val
US04343804,CCOC(=O)c1cnc2c(OC)cccc2c1O.O=P(Cl)(Cl)Cl>>CCOC(=O)c1cnc2c(OC)cccc2c1Cl,,Cc1ccccc1,,,,val
US05207947,CCCCCCCCC(OC(=O)c1ccc(OCc2ccccc2)cc1)C(F)(F)F>>CCCCCCC(OC(=O)c1ccc(OCc2ccccc2)cc1)C(F)(F)F,[Pd],CO,,,,val
US20050245503A1,NNc1ncc(C(=O)O)cc1Cl.S=C=NC(Cc1ccccc1)c1ccccc1>>O=C(O)c1cnc(NNC(=S)NC(Cc2ccccc2)c2ccccc2)c(Cl)c1,,CC(=O)N(C)C,,,,val
US04786646,NCCCCc1cccnc1.O=C(CC[C@@H]1CC1(c1ccccc1)c1ccccc1)Oc1ccc([N+](=O)[O-])cc1>>O=C(CC[C@@H]1CC1(c1ccccc1)c1ccccc1)NCCCCc1cccnc1,,C1CCOC1,,,,val
US20100152188A1,CO.Nc1nc(CC(=O)O)cs1>>COC(=O)Cc1csc(N)n1,,CO,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20110306589A1,CCOC(=O)c1nnsc1NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)Nc1snnc1C(=O)O,,C1CCOC1,CCO,[Li+].[OH-],,val
US05677291,CC(C)(C)c1cc(S)cc(C(C)(C)C)c1O.CCCCCCCCCCCC[Si](C)(C)CCl>>CCCCCCCCCCCC[Si](C)(C)CSc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20110060009A1,Cc1[nH]c2ccccc2c1C[C@H]1C[C@H](N=[N+]=[N-])CN1C(=O)OC(C)(C)C>>Cc1[nH]c2ccccc2c1C[C@H]1C[C@H](N=[N+]=[N-])CN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030013875A1,CCCCCCN1CC2C(C1=O)C2(C)c1cccc(O)c1>>CCCCCCN1CC2C(C1)C2(C)c1cccc(O)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060223853A1,Cc1ccc(S(=O)(=O)OC[C@H]2CO2)cc1.Oc1cccc2ncccc12>>c1ccc2c(OC[C@H]3CO3)ccnc2c1,,CN(C)C=O,,[H-].[Na+],,val
US20130287730A1,CC(C)(C)OC(=O)N1CCC(N2CCNCC2)CC1.Nc1cc(OC(F)(F)F)c(Br)cc1Cl.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)N1CCC(N2CCN(C(=O)Nc3cc(OC(F)(F)F)c(Br)cc3Cl)CC2)CC1,,ClCCl,,,,val
US20140275523A1,CC(N)=NNC(C)C.O=C(O)c1cn2c(n1)-c1ccc(Br)cc1OCC2>>CC(=NC(=O)c1cn2c(n1)-c1ccc(Br)cc1OCC2)NNC(C)C,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20150329506A1,CC(=O)c1ccn[nH]1.CI>>CC(=O)c1ccnn1C,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20080214578A1,CC(C)(F)C[C@@H](N)CO.C[C@H](Sc1nc(Cl)c2sc(N)nc2n1)c1ccccc1F>>C[C@H](Sc1nc(N[C@@H](CO)CC(C)(C)F)c2sc(N)nc2n1)c1ccccc1F,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,O,val
US20100305085A1,CCOC(=O)C(=CN(C)C)n1ccnc1.NNc1cc(N2CCCCC2)ncn1>>O=c1c(-n2ccnc2)c[nH]n1-c1cc(N2CCCCC2)ncn1,,CCOC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090036489A1,CC(C)(C)OC(=O)NC1CCCNC1.COC(=O)COc1ccccc1I>>COC(=O)COc1ccccc1N1CCCC(NC(=O)OC(C)(C)C)C1,I[Cu]I,CS(C)=O,,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US20090082434A1,Cc1ccc(S(=O)(=O)OCC2Cc3c(F)ccc(Br)c3O2)cc1.OB(O)c1ccccc1>>Cc1ccc(S(=O)(=O)OCC2Cc3c(F)ccc(-c4ccccc4)c3O2)cc1,Cc1ccccc1[P](c1ccccc1C)(c1ccccc1C)[Pd](Cl)(Cl)[P](c1ccccc1C)(c1ccccc1C)c1ccccc1C,,,O=C([O-])[O-].[K+].[K+],,val
US20030162808A1,CC1(C)CCCNC1.CS(=O)(=O)C(=C1CN([C@@H](c2ccc(Cl)cc2)c2ccc(CCl)cc2)C1)c1cc(F)cc(F)c1>>CC1(C)CCCN(Cc2ccc([C@H](c3ccc(Cl)cc3)N3CC(=C(c4cc(F)cc(F)c4)S(C)(=O)=O)C3)cc2)C1,,ClCCl,,,,val
US20110312963A1,CC(C)(C)OC(=O)Nc1cc(Oc2ccc([N+](=O)[O-])cc2)ncn1>>Nc1cc(Oc2ccc([N+](=O)[O-])cc2)ncn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140243283A1,CC(=O)OC[C@H]1O[C@H](c2ccc(NC(=O)OC(C)(C)C)cc2)C=C[C@@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@H](c2ccc(N)cc2)C=C[C@@H]1OC(C)=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130059834A1,CCCC[Sn](Cl)(CCCC)CCCC.Cn1nc(I)c2cc(C#N)ccc21>>CCCC[Sn](CCCC)(CCCC)c1nn(C)c2ccc(C#N)cc12,,C1CCOC1,,CC(C)[Mg]Cl,,val
US04098600,CC(C)N(C(=O)CN)c1ccccc1.O=CO>>CC(C)N(C(=O)CNC=O)c1ccccc1,,Cc1ccccc1,,,,val
US20090054422A1,CS(=O)(=O)Cl.N#Cc1ccc(COCCO)cc1>>CS(=O)(=O)OCCOCc1ccc(C#N)cc1,,ClCCl,ClCCl,CCN(CC)CC,,val
US20150197511A1,CC(C)(C)OC(=O)N1CC(Oc2cc(NC(=O)Oc3ccccc3)cc(C(F)(F)F)c2)C1.Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1>>CC(C)(C)OC(=O)N1CC(Oc2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3)cc(C(F)(F)F)c2)C1,CN(C)c1ccncc1,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20150111894A1,COC(=O)Cc1oc(Br)cc1C(=O)OC.OB(O)c1ccc(Cl)cc1>>COC(=O)Cc1oc(-c2ccc(Cl)cc2)cc1C(=O)OC,,O,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20060135578A1,CCOP(=O)(CP(=O)(OCC)OCC)OCC.COc1cc(COc2nn(CCO)cc2C=O)ccc1OCc1nc(-c2ccco2)oc1C>>CCOP(=O)(/C=C/c1cn(CCO)nc1OCc1ccc(OCc2nc(-c3ccco3)oc2C)c(OC)c1)OCC,,O,,CN(C)C=O,[H-].[Na+],val
US20140371202A1,C1COCCN1.CC(C)(O)C#N.O=C1CCOCC1>>N#CC1(N2CCOCC2)CCOCC1,,CC(=O)N(C)C,,O=S(=O)([O-])[O-].[Mg+2],,val
US20070173646A1,C1CCOC1.CCOC(=O)C12CCN(CC1)CC2.[Li]c1ccccc1>>OC(c1ccccc1)(c1ccccc1)C12CCN(CC1)CC2,,C1CCOC1,,,,val
US20100184815A1,Cc1ccc(Cn2nncc2COC(=O)c2ccc(SC(C)(C)C(=O)OC(C)(C)C)cc2)cc1>>Cc1ccc(Cn2nncc2COC(=O)c2ccc(SC(C)(C)C(=O)O)cc2)cc1,,C1COCCO1,,Cl,,val
US06326369B1,COC(=O)c1ccc(OCCCC2Cc3c(c(OC)c(OC)c(OC)c3OC)C2)cc1>>COc1c2c(c(OC)c(OC)c1OC)CC(CCCOc1ccc(C(=O)O)cc1)C2,,CO,,[Na+].[OH-],,val
US20110257151A1,CC1(C)Cc2cc(C#N)ccc2NC1c1cccc(N)c1.COC(=O)C(C)(C)Br>>COC(=O)C(C)(C)Nc1cccc(C2Nc3ccc(C#N)cc3CC2(C)C)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160264536A1,N#Cc1cccs1.[Cl-].[NH4+]>>Cl.N=C(N)c1cccs1,,CO,,C[O-].[Na+],,val
US20110034461A1,O=C(O)c1cccc(S(F)(F)(F)(F)F)c1.O=[N+]([O-])[O-]>>Nc1cc(C(=O)O)cc(S(F)(F)(F)(F)F)c1,[Pd],,,[H][H],,val
US20100286148A1,Cc1cc(Cl)cc(C#N)n1.OCC(F)(F)F>>Cc1cc(OCC(F)(F)F)cc(C#N)n1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20040044012A1,C=CCN.CSc1ncc(C(=O)Cl)c(NC(C)C)n1>>C=CCNC(=O)c1cnc(SC)nc1NC(C)C,,C1CCOC1,CCOC(C)=O,,,val
US04115416,CCCCCCCC(Br)C(=O)OCC.Oc1ccc(C2=CCCCC2)cc1>>CCCCCCCC(Oc1ccc(C2CCCCC2)cc1)C(=O)OCC,,CCO,,[Na],,val
US20150232469A1,Cc1cccc(CN2CCNCC2)c1.Clc1nc2cccnc2nc1Cl>>Cc1cccc(CN2CCN(c3nc4ncccc4nc3Cl)CC2)c1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20030013741A1,N#Cc1cccc(N=C=O)c1.NC(Cc1ccccc1)C(O)CN1CCC(Cc2ccc(F)cc2)CC1>>N#Cc1cccc(NC(=O)NC(Cc2ccccc2)C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1,,C1CCOC1,,,,val
US06248740B1,CCOC(=O)C(C)(C)c1cn2nc(Cl)ccc2n1.NCCCN1CCC(OC2c3ccccc3CCc3ccccc32)CC1>>CCOC(=O)C(C)(C)c1cn2nc(NCCCN3CCC(OC4c5ccccc5CCc5ccccc54)CC3)ccc2n1,,CN1CCCC1=O,,O=C([O-])O.[Na+],,val
US04666907,CC(=O)O.COc1ccc2c(c1)Sc1c(cc(OC)c(O)c1Br)N2C(=O)OC(C)Cl>>COc1ccc2c(c1)Sc1c(cc(OC)c(O)c1Br)N2C(=O)OC(C)OC(C)=O,,CCOC(C)=O,,,,val
US20140329820A1,CC(C)(C)OC(=O)N1CC[C@@H](N)[C@H](O)C1.O=C(Cl)C1CC1>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)C2CC2)[C@H](O)C1,,C1CCOC1,,CCN(CC)CC,,val
US20090311217A1,ClCCI.O=Cc1c[nH]c2cccc(Br)c12>>O=Cc1cn(CCCl)c2cccc(Br)c12,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20100137278A1,O=C1CCCC(c2nccnc2F)C1.Oc1ccc(Nc2nc3ccccc3s2)cc1>>O=C1CCCC(c2nccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1,,CN1CCCC1=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04024151,C1=C(c2ccccc2)CCNC1.Cl.O.O=C1CCCC(=O)N1CCCCBr>>Cl.O=C(O)CCCC(=O)NCCCCN1CC=C(c2ccccc2)CC1,,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20100210651A1,COC(=O)c1cc(=O)[nH]o1.Cc1onc(-c2ccc(F)cc2)c1CO>>COC(=O)c1cc(OCc2c(-c3ccc(F)cc3)noc2C)no1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130096133A1,BrCc1ccc2ccccc2c1.C1CNCCN1>>c1ccc2cc(CN3CCNCC3)ccc2c1,,C1CCOC1,,,,val
US20150118601A1,C[N+](=O)[O-].O=C(/C=C/c1ccccc1)c1ccc(F)cc1>>O=C(CC(C[N+](=O)[O-])c1ccccc1)c1ccc(F)cc1,,CO,,CCNCC,,val
US20100261728A1,FC(F)(F)c1ccc([C@H]2NCCc3ccccc32)cc1.O=C(Cl)c1ccc2nonc2c1>>O=C(c1ccc2nonc2c1)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05591752,N#Cc1cccc2c1COc1ccc(OCc3ccc4ccc(Cl)cc4n3)cc1C2SCCC(=O)O.O>>NC(=O)c1cccc2c1COc1ccc(OCc3ccc4ccc(Cl)cc4n3)cc1C2SCCC(=O)O,,CCO,,[Na+].[OH-],,val
US20140140956A1,CN(C)C(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.COc1cc(OC)c2c(=O)[nH]c(-c3cccc(Br)n3)cc2c1>>COc1cc(OC)c2c(=O)[nH]c(-c3cccc(-c4ccc(C(=O)N(C)C)cc4)n3)cc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,O,CCO,O=C([O-])[O-].[K+].[K+],val
US20100261755A1,COC(=O)N1CC[C@H](c2cc(=O)[nH]o2)C[C@@H]1Cc1cc(C(C)(C)C)cc(C(C)(C)C)c1>>CC(C)(C)c1cc(C[C@H]2C[C@@H](c3cc(=O)[nH]o3)CCN2)cc(C(C)(C)C)c1,,Br,,CC(=O)O,,val
US20150175556A1,CC1=C(C(=O)OCc2ccccc2)C(c2ccccc2)NC(=O)N1>>CC1=C(C(=O)O)C(c2ccccc2)NC(=O)N1,[Pd],CO,,,,val
US20090227640A1,CC(C)(C)c1ccc(CBr)cc1.COC(=O)c1ccc(CC(/C=C/c2ccccc2O)CCCCC#N)cc1>>COC(=O)c1ccc(CC(/C=C/c2ccccc2OCc2ccc(C(C)(C)C)cc2)CCCCC#N)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20140296307A1,N#Cc1cc([N+](=O)[O-])ccc1F.Nc1ccccc1-c1ccccc1>>N#Cc1cc([N+](=O)[O-])ccc1Nc1ccccc1-c1ccccc1,,CS(C)=O,O,CC(C)(C)[O-].[K+],,val
US20140155381A1,CS(=O)(=O)Nc1cccc(C=O)c1.Cc1ccc(Br)c(C)c1>>Cc1ccc(C(O)c2cccc(NS(C)(=O)=O)c2)c(C)c1,,C1CCOC1,,O,[Li]CCCC,val
US04262004,CCNc1ccc2c(c1)N1CCN=C1S2.Cl>>CCNc1ccc2c(c1)N1CCN=C1S2.Cl,,CC(C)O,,CC(=O)O,,val
US05262385,CCOC(=O)C1CCCCC1=O.O=S(=O)(Cl)Cl>>CCOC(=O)C1(Cl)CCCCC1=O,,ClC(Cl)(Cl)Cl,,,,val
US04923869,CC(=O)Cl.CC1CC(=O)NN=C1c1ccc2nc(-c3ccc(N)o3)[nH]c2c1>>CC(=O)Nc1ccc(-c2nc3ccc(C4=NNC(=O)CC4C)cc3[nH]2)o1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20090048320A1,CCCCN.CN1C(=O)C(c2ccc(OC(F)F)cc2)(c2cccc(C=O)c2)N=C1N>>CCCCNCc1cccc(C2(c3ccc(OC(F)F)cc3)N=C(N)N(C)C2=O)c1,,CO,,[Na+].[OH-],,val
US20140010783A1,Nc1ccc(Br)c(Cl)c1.S=C(n1ccnc1)n1ccnc1>>S=C=Nc1ccc(Br)c(Cl)c1,,ClCCl,,,,val
US20100075948A1,CC(C)(C)OC(=O)CN.CC(C)CC=O>>CC(C)C/C=N/CC(=O)OC(C)(C)C,,ClCCl,,,,val
US20070032532A1,CI.COCOc1cc(CCO)cc(OCOC)c1>>COCCc1cc(OCOC)cc(OCOC)c1,,CN(C)C=O,O,[H-].[Na+],[Cl-].[NH4+],val
US04791133,C#CCC(O)c1ccc(Br)cc1.CC(C)(C)[Si](C)(C)Cl>>C#CCC(O[Si](C)(C)C(C)(C)C)c1ccc(Br)cc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20080103129A1,COc1ccc(B(O)O)cc1.O=C1[C@H](NS(=O)(=O)c2ccc(Br)s2)CC=CCN1OCc1ccccc1>>COc1ccc(-c2ccc(S(=O)(=O)N[C@@H]3CC=CCN(OCc4ccccc4)C3=O)s2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20100261755A1,COC(=O)c1ccnc(Br)c1.OB(O)c1cccc(C(F)(F)F)c1>>COC(=O)c1ccnc(-c2cccc(C(F)(F)F)c2)c1,Cl[Pd]Cl,CO,ClCCl,O,O=C([O-])[O-].[K+].[K+],val
US20060063828A1,BrBr.COc1cccc(OC)c1C=O>>COc1ccc(Br)c(OC)c1C=O,,ClCCl,,,,val
US20110086834A1,COCCOCCBr.Nc1ncc(Cl)c(-c2c[nH]c3ccc(C#CC4(O)CCCC4)cc23)n1>>COCCOCCn1cc(-c2nc(N)ncc2Cl)c2cc(C#CC3(O)CCCC3)ccc21,,CCOCC,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050080124A1,COc1ccc([N+](=O)[O-])cc1-c1c(Cl)c(C(F)(F)F)nn1C>>COc1ccc(N)cc1-c1c(Cl)c(C(F)(F)F)nn1C,,CCO,,,,val
US06235789B1,COc1ccc2c(c1)C(=CC#N)CCC2>>COc1ccc2c(c1)C(CCN)CCC2,[Ni],CCO,,N,,val
US20110245196A1,Br.CC(=O)OC[C@H]1O[C@H](O[C@@H]2[C@@H](COC(C)=O)OC(OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1O[C@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@H](O[C@@H]2[C@@H](COC(C)=O)O[C@H](Br)[C@H](OC(C)=O)[C@H]2OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1O[C@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O,,ClCCl,,CC(=O)O,,val
US20080009482A1,CC(C)=O.CCC(CC)(CN)C(=O)OC>>CCC(CC)(CNC(C)C)C(=O)OC,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20130324516A1,CC(C)I.Nc1ncnc2ccc(-c3cccc(F)c3)nc12>>CC(C)Nc1ncnc2ccc(-c3cccc(F)c3)nc12,,CN(C)C=O,,[H-].[Na+],,val
US05100893,CCC(=O)CBr.NC(=S)c1ccc(O)cc1>>Br.CCc1csc(-c2ccc(O)cc2)n1,,CCO,,,,val
US20120178751A1,Nc1cnc(Cl)cn1.O=C(CBr)c1ccc(C(F)(F)F)c([N+](=O)[O-])c1>>O=[N+]([O-])c1cc(-c2cn3cc(Cl)ncc3n2)ccc1C(F)(F)F,,CC#N,,,,val
US20080139639A1,CN(Cc1cc(Br)n(S(=O)(=O)c2ccccc2)c1)C(=O)OC(C)(C)C.OB(O)c1ccccc1>>CN(Cc1cc(-c2ccccc2)n(S(=O)(=O)c2ccccc2)c1)C(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20030171309A1,CON=C1C[C@@H](C(=O)Nc2ccccc2N)N(C(=O)OC(C)(C)C)C1>>CON=C1C[C@@H](c2nc3ccccc3[nH]2)N(C(=O)OC(C)(C)C)C1,,CC(=O)O,ClCCl,O=C([O-])O.[Na+],,val
US06207365B1,CC(=O)O.CCOC(=O)C(C)=Cc1ccc(OC)cc1OC>>CCOC(=O)C(C)=Cc1c(OC)cc(OC)cc1OC(C)=O,,c1ccncc1,,,,val
US06518273B1,CC(C)(C)OC(=O)N1CCN(c2cccc(O)c2)CC1.CCBr>>CCOc1cccc(N2CCNCC2)c1,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130225588A1,COC(=O)Cc1cc2ccc(Cl)cc2c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c1C>>Cc1c(CC(=O)O)cc2ccc(Cl)cc2c1-c1ccc(NC(=O)Nc2ccccc2)cc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20120077799A1,Clc1ccccn1.O=S1(=O)CCN2C=CC=C(c3ccc(O)cc3)C2=N1>>O=S1(=O)CCN2C=CC=C(c3ccc(Oc4ccccn4)cc3)C2=N1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04001336,C1CCOC1.C=C[Mg]Cl.CCC(C)C=O.O>>C=CC(O)C(C)CC.C=CCO,,C1CCOC1,,,,val
US20130331387A1,CC(C)(C)N.O=S(=O)(Cl)c1ccc(Br)c2c1CCCC2>>CC(C)(C)NS(=O)(=O)c1ccc(Br)c2c1CCCC2,,C1CCOC1,,O,,val
US05011849,CC(C)(C)OC(=O)NCCN.CCOC(=O)c1ncsc1-c1ccccc1>>CC(C)(C)OC(=O)NCCNC(=O)c1ncsc1-c1ccccc1,,CCO,,,,val
US20140228409A1,CC(CC(=O)O)CC(=O)Nc1ccc(C#N)cn1.CCn1c2ccccc2c2cc(N)ccc21>>CCn1c2ccccc2c2cc(NC(=O)CC(C)CC(=O)Nc3ccc(C#N)cn3)ccc21,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090082365A1,CC(C)C(=O)Cl.Nc1cc([N+](=O)[O-])ccc1C(=O)O>>CC(C)C(=O)Nc1cc([N+](=O)[O-])ccc1C(=O)O,,ClCCl,,,,val
US20140275049A1,COC(=O)c1ccc(-c2cc(-c3cc(C(C)(C)C)cc(C(C)(C)C)c3)n(-c3ccc(NS(C)(=O)=O)cc3)n2)cc1>>CC(C)(C)c1cc(-c2cc(-c3ccc(C(=O)O)cc3)nn2-c2ccc(NS(C)(=O)=O)cc2)cc(C(C)(C)C)c1,,C1CCOC1,CO,[Li+].[OH-],,val
US05436334,Cc1ccc(S(=O)(=O)OCCO[C@@H]2CN(C(=O)c3ccccc3)C[C@H]2Br)cc1.NCc1ccccc1>>O=C(c1ccccc1)N1C[C@H]2OCCN(Cc3ccccc3)[C@H]2C1,,Cc1ccccc1C,,,,val
US20110098297A1,CCOC(=O)c1cc2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O)c2[nH]1.CO>>CCOC(=O)c1cc2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(OC)c2[nH]1,,CCOC(C)=O,,C[Si](C)(C)C=[N+]=[N-],,val
US20110065702A1,COc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4ccccn4)n[nH]c3c1)C(=O)N2.O=C(OO)c1cccc(Cl)c1>>COc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4cccc[n+]4[O-])n[nH]c3c1)C(=O)N2,,ClCCl,,,,val
US20100104979A1,CO.O=C(O)C1CCCCC1(O)C(=O)c1ccccc1>>COC(=O)C1CCCCC1(O)C(=O)c1ccccc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20140323470A1,CS(=O)(=O)Cl.C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(CO)c4)c4ccccc43)cn12>>C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(COS(C)(=O)=O)c4)c4ccccc43)cn12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160194350A1,C=CC[Sn](CCCC)(CCCC)CCCC.CCC(OC(=O)c1ccccc1)[C@@H]1C[C@@H](OC(=S)Oc2ccccc2)[C@H](n2c(=O)sc3c(=O)[nH]c(N)nc32)O1>>C=CC[C@@H]1C[C@@H](C(CC)OC(=O)c2ccccc2)O[C@H]1n1c(=O)sc2c(=O)[nH]c(N)nc21,,Cc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20070254931A1,CCOC(=O)c1nc(NC(C)=O)sc1Cc1ccc(SC)cc1>>CSc1ccc(Cc2sc(NC(C)=O)nc2C=O)cc1,,C1CCOC1,,[BH4-].[Li+],,val
US07271266B2,COC(=O)c1cc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)nc1Oc1ccc(F)c(F)c1>>O=C(O)c1cc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)nc1Oc1ccc(F)c(F)c1,,CO,,[Na+].[OH-],,val
US20030176454A1,Cc1ncccc1Oc1ccc(NC(=S)NC(=O)c2ccccc2)cn1>>Cc1ncccc1Oc1ccc(NC(N)=S)cn1,,CO,,Cl,[Na+].[OH-],val
US20080171737A1,BrCCCBr.O=S1(=O)CCc2cc(Cl)ccc2N1c1ccccc1F>>O=S1(=O)C(CCCBr)Cc2cc(Cl)ccc2N1c1ccccc1F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20030055261A1,CC(C)(C)OC(=O)N[C@H](Cc1csc2ccccc12)C(=O)O.CI>>CN(C(=O)OC(C)(C)C)[C@H](Cc1csc2ccccc12)C(=O)O,,C1CCOC1,O,CCOC(C)=O,[H-].[Na+],val
US20040097507A1,C[Si](C)(C)I.Cc1onc2c1c(=O)n(C1CCCC(CNC(=O)OCc3ccccc3)C1)c1ccncc21>>Cc1onc2c1c(=O)n(C1CCCC(CN)C1)c1ccncc21.I,,ClCCl,,,,val
US20090030012A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.FC(F)(F)c1cc(-c2ccnc(Cl)n2)cc(C(F)(F)F)c1>>CC(C)(C)OC(=O)N1CC=C(c2nccc(-c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20120101136A1,CCOC(=O)CCCCOc1ccc(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)c(Cl)c1>>CC(C)Oc1ccc(-c2nc(-c3ccc(OCCCCC(=O)O)cc3Cl)no2)cc1C#N,,CC(C)O,O,[Na+].[OH-],,val
US20070191372A1,CN(CCNC(=O)C(F)(F)F)CCNc1n[n+]([O-])c2ccccc2[n+]1[O-].O=C(c1cccc2cc3ccccc3nc12)n1ccnc1>>CN(CCNC(=O)c1cccc2cc3ccccc3nc12)CCNc1n[n+]([O-])c2ccccc2[n+]1[O-],,CO,,N,,val
US20020183259A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cc1cc(CO[Si](C)(C)C(C)(C)C)cc(C)c1O>>Cc1cc(CO[Si](C)(C)C(C)(C)C)cc(C)c1OC(=O)C(C)NC(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20050014794A1,CC(C)COC(=O)Cl.NC1(C(=O)O)CCc2ccccc2C1>>CC(C)COC(=O)NC1(C(=O)O)CCc2ccccc2C1,,C1COCCO1,,Cl,[Na+].[OH-],val
US20140066614A1,O=C(O)C(F)(F)F.O=c1ccn2c(n1)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]12>>O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)[nH]1,,CN(C)C=O,,,,val
US20140256713A1,COC(=O)Cl.NCCn1c(=O)c(C(=O)NCCCN2CCOCC2)c(O)c2ncc(Cc3ccc(F)cc3)cc21>>COC(=O)NCCn1c(=O)c(C(=O)NCCCN2CCOCC2)c(O)c2ncc(Cc3ccc(F)cc3)cc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04448990,[N-]=[N+]=NC1CCc2c(ccc(OCc3ccccc3)c2C(N)=O)C1>>NC(=O)c1c(O)ccc2c1CCC(N)C2,[Pd],CCO,,,,val
US20130190290A1,COc1ccc(Cn2cc(-c3cc4n(-c5cc(NC(=O)c6cc(C#N)cc(S(F)(F)(F)(F)F)c6)ccc5C)ccn4n3)cn2)cc1>>Cc1ccc(NC(=O)c2cc(C#N)cc(S(F)(F)(F)(F)F)c2)cc1-n1ccn2nc(-c3cn[nH]c3)cc12,,O=C(O)C(F)(F)F,,,,val
US20050075392A1,CCOC(=O)C[C@H](CCOc1ccc(Cl)cc1)NC(=O)C1(C[C@@H](CCOC)C(=O)O)CCCC1>>COCC[C@H](CC1(C(=O)N[C@@H](CCOc2ccc(Cl)cc2)CC(=O)O)CCCC1)C(=O)O,,C1COCCO1,,[Na+].[OH-],,val
US20070265328A1,C=CC[C@]1(C(=O)OC)C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OC(C)(C)C>>C=CC[C@]1(C(=O)OC)C[C@@H](O)CN1C(=O)OC(C)(C)C,,C1CCOC1,,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US03934008,COC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1>>COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(N)=O,[Pd],CC(C)(C)O,O,,,val
US05618811,Cc1ccc(S(=O)(=O)Cl)cc1.Cc1ccccc1C1CCC(=NO)C(c2ccccc2)C1>>Cc1ccccc1C1CCC(=O)NC(c2ccccc2)C1,,c1ccncc1,,Cl,,val
US20010034352A1,COc1ncccc1[N+](=O)[O-].N#CCOc1ccc(Cl)cc1>>COc1nccc(CC#N)c1[N+](=O)[O-],,CN(C)C=O,,Cl,CC(C)(C)[O-].[K+],val
US05824699,CCc1cccc2c3c([nH]c12)C(CC)(CC(=O)OC)OCC3=NO>>CCc1cccc2c3c([nH]c12)C(CC)(CC(=O)O)OCC3=NO,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US20080188521A1,CCC(OC(=O)c1ccc([N+](=O)[O-])cc1)(c1cn(Cc2ccc3c(-c4ccc(F)cc4)cc(Cl)nc3c2)nn1)C(F)(F)F>>CC[C@](O)(c1cn(Cc2ccc3c(-c4ccc(F)cc4)cc(Cl)nc3c2)nn1)C(F)(F)F,,C1CCOC1,,O,[Li+].[OH-],val
US20150329593A1,C[C@@H](NC(=O)[C@@H]1CCCN1)C(=O)OCc1ccccc1.O=C(N[C@@H](Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)C(=O)O)OCC1c2ccccc2-c2ccccc21>>C[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)OCc1ccccc1,,CN(C)C=O,ClCCl,Cl,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120225062A1,CC(C)(O)c1cc(F)cc(F)c1.CI>>COC(C)(C)c1cc(F)cc(F)c1,,CN(C)C=O,,[H-].[Na+],,val
US20100113462A1,CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2cc(F)c(F)cc2C1>>Cc1cccc(C(=O)NC2(C(=O)O)Cc3cc(F)c(F)cc3C2)c1CC(C)C,[Pd],CC(=O)O,,,,val
US20120022043A1,Cc1ccccc1-c1nocc1NC(=O)OC(C)(C)C.O=C(Cl)c1cnn2ccc(Cl)nc12>>Cc1ccccc1-c1nocc1NC(=O)c1cnn2ccc(Cl)nc12,,C1COCCO1,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20150045377A1,FC(F)(F)CI.O=c1[nH]cnc2sccc12>>O=c1c2ccsc2ncn1CC(F)(F)F,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20090163586A1,C/C(=C\c1ccc(Cl)cc1)S(=O)(=O)Nc1ccccc1S(N)(=O)=O>>CC(Cc1ccc(Cl)cc1)S(=O)(=O)Nc1ccccc1S(N)(=O)=O,[Pd],CCOC(C)=O,,[H][H],,val
US20090270460A1,CC(C)c1cnn(-c2c(Cl)cccc2Cl)c1CO.CCCCCC.COC(=O)C=Cc1ccc(-c2ccc(O)cc2C)cc1>>CCOC(=O)C=Cc1ccc(-c2ccc(OCc3c(C(C)C)cnn3-c3c(Cl)cccc3Cl)cc2C)cc1,,CCCCCC,Cc1ccccc1,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20110003820A1,CC1c2ccc(C(=O)NC3CC3)n2CCN1C(=O)OC(C)(C)C>>CC1NCCn2c(C(=O)NC3CC3)ccc21,,CO,,Cl,,val
US20060111362A1,CCOc1ccncc1[N+](=O)[O-].CN>>CNc1ccncc1[N+](=O)[O-],,CO,,CCOC(C)=O,,val
US06239131B1,Cc1ccc2c(c1)N(CC(=O)c1cccs1)C(=O)C(NC(=O)OC(C)(C)C)CN2C(=O)C(C)(C)C>>Cc1ccc2c(c1)N(CC(=O)c1cccs1)C(=O)C(N)CN2C(=O)C(C)(C)C,,C1COCCO1,Cl,,,val
US20040260088A1,N#Cc1ccc(C(F)(F)F)cc1F.O=Cc1ccc(O)cc1Br>>N#Cc1ccc(C(F)(F)F)cc1Oc1ccc(Br)c(C=O)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080207902A1,CCc1cc2c(OC)cccn2n1.O=C1CCC(=O)N1Cl>>CCc1nn2cccc(OC)c2c1Cl,,CN(C)C=O,,O,,val
US20100105680A1,CC1(C)[C@@H](CCOCc2ccccc2)C[C@H]1CN1CCN(c2ccccc2)CC1.O=C(O)C(=O)O>>CC1(C)[C@@H](CCOCc2ccccc2)C[C@H]1CN1CCN(c2ccccc2)CC1.O=C(O)C(=O)O,,CCO,,O,O,val
US20030100554A1,CCc1n[nH]c(CCOCc2ccccc2)c1Oc1cc(C#N)cc(C#N)c1>>CCc1n[nH]c(CCO)c1Oc1cc(C#N)cc(C#N)c1,Cl[Fe](Cl)Cl,ClCCl,,,,val
US20050148627A1,BrBr.Cc1cccc(C=O)c1O>>Cc1cc(Br)cc(C=O)c1O,,CC(=O)O,O,,,val
US05703098,CCOc1cc(C(N)CC(=O)OC)ccc1OC>>CCOc1cc(C(N)CCO)ccc1OC,,CO,,[BH4-].[Na+],,val
US04262004,Nc1nc2ccccc2s1.O=C(CBr)c1ccc(Cl)cc1>>Br.N=c1sc2ccccc2n1CC(=O)c1ccc(Cl)cc1,,CC#N,,,,val
US20140256756A1,CS(=O)(=O)c1ccc(O[C@H]2CCN(C3CCNCC3)C2=O)c(F)c1.Clc1nc(Br)ns1>>CS(=O)(=O)c1ccc(O[C@H]2CCN(C3CCN(c4nc(Br)ns4)CC3)C2=O)c(F)c1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,Cl,val
US20100197673A1,CC(C)(C)OC(=O)c1ccc(-c2cc3cc(Cl)cc(NC4CCCC4)c3[nH]2)c(N)c1>>Nc1ccc(-c2cc3cc(Cl)cc(NC4CCCC4)c3[nH]2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090036443A1,CCOC(=O)c1cc2c(C3CCCCC3)c(-c3ccccc3)[nH]c2s1>>O=C(O)c1cc2c(C3CCCCC3)c(-c3ccccc3)[nH]c2s1,,C1CCOC1,CO,[Na+].[OH-],,val
US20080161294A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@H](CO)NCc1ccccc1NC(=O)c1ccc(N2CCCC2)cc1Cl>>C[C@H](CO)N(Cc1ccccc1NC(=O)c1ccc(N2CCCC2)cc1Cl)C(=O)OC(C)(C)C,,ClCCl,,,,val
US20030199440A1,CC(C)(C)OC(=O)[C@@H](N)CCC(N)=O.O=S(=O)(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>CC(C)(C)OC(=O)[C@H](CCC(N)=O)NS(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1,,ClCCl,,CCN(CC)CC,Cl,val
US20150005329A1,COc1cc(F)ccc1-c1nc(Cl)ncc1F.CSCc1cc(N)cc(Br)c1>>COc1cc(F)ccc1-c1nc(Nc2cc(Br)cc(CSC)c2)ncc1F,,CCCCO,CCOC(C)=O,C1COCCO1,Cl,val
US20080039458A1,CC1NCCc2ccc(F)cc21.O=C(O)c1cc2ncc(Br)cn2n1>>CC1c2cc(F)ccc2CCN1C(=O)c1cc2ncc(Br)cn2n1,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20120010163A1,CN.COC(=O)c1c(C)cc2c(c1O)[C@]1(O)C(=O)c3cc4c(c(O)c3C(=O)[C@]1(OC)[C@H](O)C2)C(=O)C=C(N[C@H]1O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]1OC)C4=O>>C/N=C1\C=C(N[C@H]2O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]2OC)C(=O)c2cc3c(c(O)c21)C(=O)[C@]1(OC)[C@H](O)Cc2cc(C)c(C(=O)OC)c(O)c2[C@]1(O)C3=O,,CO,,,,val
US05338739,COc1cccc(C2CCCN2)c1.O=C1c2ccccc2C(=O)N1CCBr>>COc1cccc(C2CCCN2CCN2C(=O)c3ccccc3C2=O)c1,,CC#N,,[I-].[K+],,val
US20140005382A1,CI.O=C1COc2c(cccc2[N+](=O)[O-])N1>>CN1C(=O)COc2c1cccc2[N+](=O)[O-],,CN(C)C=O,,O,[H-].[Na+],val
US20150065522A1,CCOC(=O)C(CC)C(C)=O.CCOC(=O)c1cn[nH]c1N>>CCOC(=O)c1cnn2c(=O)c(CC)c(C)[nH]c12,,CC(=O)O,,,,val
US05439917,Cc1c(-c2ccc(Br)cc2)[nH]c2ncccc12.O=C=O>>Cc1c(-c2ccc(C(=O)O)cc2)[nH]c2ncccc12,,C1CCOC1,,[Li]CCCC,,val
US04921939,CI.CS(N)(=O)=O.N#Cc1ccc(N=C=S)cc1>>CSC(=NS(C)(=O)=O)Nc1ccc(C#N)cc1,,CC(C)=O,O,CCO,[Na+].[OH-],val
US05534515,CN(C)C=O.Cc1c(Br)c2cnnc(OCc3ccccc3)c2n1Cc1ccccc1>>Cc1c(C=O)c2cnnc(OCc3ccccc3)c2n1Cc1ccccc1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20080153837A1,ON=C1c2ccccc2-c2c1cccc2-c1nc2cc(C(F)(F)F)ccc2[nH]1>>NC1c2ccccc2-c2c(-c3nc4cc(C(F)(F)F)ccc4[nH]3)cccc21,[Ni],C1CCOC1,CCO,[H][H],,val
US20070213359A1,Fc1ccc(OC2CCNCC2)cc1.O=C(NCc1cccc(Cl)c1)c1cn(CCCCl)c2ccccc12>>O=C(NCc1cccc(Cl)c1)c1cn(CCCN2CCC(Oc3ccc(F)cc3)CC2)c2ccccc12,,CC#N,CCOC(C)=O,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20120015930A1,NCC(=O)O.O=C(Cl)c1ccc(F)c(F)c1>>O=C(O)CNC(=O)c1ccc(F)c(F)c1,,C1CCOC1,CCOC(C)=O,Cl,[Na+].[OH-],val
US20140303164A1,CI.Cn1nc(NC(=O)C(F)(F)F)c2cccc(Br)c21>>CN(C(=O)C(F)(F)F)c1nn(C)c2c(Br)cccc12,,CCOC(C)=O,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US05449812,COC(=O)c1ccc(N)cc1S(=O)(=O)NC(C)(C)C.O=CO>>COC(=O)c1ccc(NC=O)cc1S(=O)(=O)NC(C)(C)C,,CN(C)C=O,,CC(=O)OC(C)=O,,val
US06302837B1,O=Cc1sc2cc3c(cc2c1Oc1ccc(Cl)cc1)OCO3>>OCc1sc2cc3c(cc2c1Oc1ccc(Cl)cc1)OCO3,,CO,,[BH4-].[Na+],,val
US20090192138A1,CSc1c(N2CCC[C@H](NC(=O)OC(C)(C)C)C2)n(Cc2ccccc2)c2c(=O)n(C)c(=O)n(C)c12>>CSc1c(N2CCC[C@H](N)C2)n(Cc2ccccc2)c2c(=O)n(C)c(=O)n(C)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US05079260,Cc1ccc2c(c1)Cc1cc(C)ccc1-2.O=C=O>>Cc1ccc2c(c1)C(C(=O)O)c1cc(C)ccc1-2,,C1CCOC1,O,[Li]CCCC,,val
US20040092498A1,CC(C)(C)OC(=O)CNCCSc1ccc(Cl)cc1>>O=C(O)CNCCSc1ccc(Cl)cc1,,C1COCCO1,Cl,,,val
US03991201,CS(=O)(=O)Cl.OCC(Cc1ccccc1)c1ccc(Cl)cc1Cl>>CS(=O)(=O)OCC(Cc1ccccc1)c1ccc(Cl)cc1Cl,,c1ccncc1,,CC(C)OC(C)C,,val
US20060052348A1,COc1ccc2cc(C(=O)CNC(=O)c3cn(C)c4ccccc34)ccc2c1>>COc1ccc2cc(-c3cnc(-c4cn(C)c5ccccc45)o3)ccc2c1,,O=P(Cl)(Cl)Cl,,,,val
US06090802,CC(C)(C)OC(=O)N1CC[C@H](NC(=O)CN)C1.O=C(N=C(NC(=O)OCc1ccc([N+](=O)[O-])cc1)n1cccn1)OCc1ccc([N+](=O)[O-])cc1>>CC(C)(C)OC(=O)N1CC[C@H](NC(=O)CNC(=NC(=O)OCc2ccc([N+](=O)[O-])cc2)NC(=O)OCc2ccc([N+](=O)[O-])cc2)C1,,C1CCOC1,,CCOC(C)=O,,val
US20070276011A1,COC(=O)CC(=O)c1ccc(O)cc1.NNc1cc(Cl)cc(Cl)c1>>O=C1CC(c2ccc(O)cc2)=NN1c1cc(Cl)cc(Cl)c1,,CCO,,,,val
US20120114696A1,COC(=O)Cc1cc(C(=O)c2ccc(C#Cc3ccccc3)c([N+](=O)[O-])c2)sc1Br>>COC(=O)Cc1cc(C(=O)c2ccc(C#Cc3ccccc3)c(N)c2)sc1Br,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US04640920,CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.CCN1CCCC1CN>>CCN1CCCC1CNS(=O)(=O)c1ccc(NC(C)=O)cc1,,ClC(Cl)Cl,,O=C([O-])[O-].[Na+].[Na+],,val
US20060135551A1,CCOC(=O)N1c2c(c(C)nn2C)C(N=Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1CC>>CCOC(=O)N1c2c(c(C)nn2C)C(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1CC,,CO,,O,[BH3-]C#N.[Na+],val
US20140051692A1,C=CC[C@@H](C)O.Cc1ccc(Br)cc1-c1c(O)cccc1Cl>>C=CC[C@H](C)Oc1cccc(Cl)c1-c1cc(Br)ccc1C,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070027112A1,CNOC.O=C(Cl)c1ccc(-c2ccccc2)cc1>>CON(C)C(=O)c1ccc(-c2ccccc2)cc1,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US03931247,CC(=O)c1ccc(-c2ccc([N+](=O)[O-])cc2)o1>>CC(O)c1ccc(-c2ccc([N+](=O)[O-])cc2)o1,,CO,,[BH4-].[Na+],,val
US20070117854A1,CC(C)(C)c1ccn(CO)n1.ClCCl.O=S(Cl)Cl>>CC(C)(C)c1ccn(CCl)n1.Cl,,ClCCl,,,,val
US20110081365A1,CCOC(=O)c1ccc(C#C[Si](CC)(CC)CC)c(C)c1>>C#Cc1ccc(C(=O)OCC)cc1C,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04559354,CSc1nnc(-c2ccc(OCC3CO3)cc2)n1C.NCCOc1ccc(O)c(C(N)=O)c1>>CSc1nnc(-c2ccc(OCC(O)CNCCOc3ccc(O)c(C(N)=O)c3)cc2)n1C,,CS(C)=O,,O,,val
US20040224939A1,CC(C)(C)OC(=O)N1CCOc2ccc(N3CC(CO)OC3=O)cc2C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCOc2ccc(N3CC(COS(C)(=O)=O)OC3=O)cc2C1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US05399578,CCCCC(=O)N(Cc1ccc(-c2ccccc2C#N)cc1)C1(C(=O)OCc2ccccc2)CCCCC1.CCCC[Sn](CCCC)(CCCC)N=[N+]=[N-]>>CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)C1(C(=O)OCc2ccccc2)CCCCC1,,Cc1ccccc1C,,,,val
US20160159752A1,C[Si](C)(C)CCOC(=O)NC1CC(F)(F)CC1CC[C@H]1CN(C(=O)OCc2ccccc2)CCN1S(=O)(=O)c1ccccc1>>NC1CC(F)(F)CC1CC[C@H]1CN(C(=O)OCc2ccccc2)CCN1S(=O)(=O)c1ccccc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05910498,CCOC(=O)c1cn(-c2cc(NC=O)c(F)cc2F)c2c(F)c(F)c(F)c(NCc3ccccc3)c2c1=O>>CCOC(=O)c1cn(-c2cc(NC=O)c(F)cc2F)c2c(F)c(F)c(F)c(N)c2c1=O,[Pd],CC(=O)O,,CCO,,val
US20100130487A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2C12COc1ccc(Br)cc12>>CC1(C)OB(c2ccc3c(c2)C2(CO3)C(=O)N(C(c3ccccc3)c3ccccc3)c3ccccc32)OC1(C)C,,CS(C)=O,O,CC(=O)[O-].[K+],,val
US20110144105A1,COCCS(=O)(=O)c1ccc(B(O)O)cc1.Cc1ccc(S(=O)(=O)OC(=CC(C)C)c2cc3cc(F)cnc3n2S(=O)(=O)c2ccccc2)cc1>>COCCS(=O)(=O)c1ccc(C(=CC(C)C)c2cc3cc(F)cnc3n2S(=O)(=O)c2ccccc2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20110028493A1,CI.COC(=O)c1ccc(Cc2nc(-c3cccc(C(F)(F)F)c3)cs2)cc1>>COC(=O)c1ccc(C(C)c2nc(-c3cccc(C(F)(F)F)c3)cs2)cc1,,C1CCOC1,,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20100152450A1,CC(C)(C)OC(=O)N1CCC[C@H]1COc1cncc(N2CCC(CCOc3ccc(OCc4ccccc4)cc3)CC2)c1>>CC(C)(C)OC(=O)N1CCC[C@H]1COc1cncc(N2CCC(CCOc3ccc(O)cc3)CC2)c1,[Pd],CO,ClCCl,,,val
US04959470,BrBr.O=Cc1cc(=O)c(OCc2ccccc2)c[nH]1>>O=Cc1[nH]cc(OCc2ccccc2)c(=O)c1Br,,CC(=O)O,,,,val
US20130296301A1,CC(C)(C)OC(=O)N(CCOCc1ccccc1)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1.CC(C)(C)[Si](C)(C)Cl>>CC(C)(C)OC(=O)N(CCOCc1ccccc1)C1=N[C@H]2[C@H](O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](O)[C@@H]2O)S1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20150315178A1,CCOC(=O)C(=O)NCc1ccc(Cl)c(C(F)(F)F)c1>>O=C(O)C(=O)NCc1ccc(Cl)c(C(F)(F)F)c1,,CCO,O,Cl,[Na+].[OH-],val
US20130090323A1,COc1ccc(B(O)O)cc1F.Nc1cc(Cl)ncc1Br>>COc1ccc(-c2cnc(Cl)cc2N)cc1F,,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090275588A1,CCN.ClCc1cscn1>>CCNCc1cscn1,,C1CCOC1,,,,val
US20160159740A1,O=Cc1cn(C(=O)OCc2ccccc2)c2ccccc12>>O=C(OCc1ccccc1)n1cc(CO)c2ccccc21,,CCO,,O,[BH4-].[Na+],val
US20040142985A1,C#Cc1ccccc1N.O=C(Cl)C(Cl)Cl>>C#Cc1ccccc1NC(=O)C(Cl)Cl,,ClCCl,,CCN(CC)CC,,val
US05272172,CCOC(C)O[C@@H]1OC=C(C(=O)OC)[C@H]2CC=C(CO)[C@H]21.CI>>CCOC(C)O[C@@H]1OC=C(C(=O)OC)[C@H]2CC=C(COC)[C@H]21,,CN(C)C=O,,[H-].[Na+],,val
US05776967,CCc1cccc2c3c([nH]c12)C(CC)(CC(=O)OC)OCC3=O.NO>>CCc1cccc2c3c([nH]c12)C(CC)(CC(=O)OC)OCC3=NO,,O,,Cl,c1ccncc1,val
US20150376129A1,CC(C)c1ccc(C(=O)O)cc1.O=[N+]([O-])O>>CC(C)c1ccc(C(=O)O)cc1[N+](=O)[O-],,O=S(=O)(O)O,,,,val
US20110028466A1,O=[N+]([O-])c1cn(CC(O)COc2ccc(OC(F)(F)F)cc2)c(Br)n1>>O=[N+]([O-])c1cn2c(n1)OC(COc1ccc(OC(F)(F)F)cc1)C2,,CN(C)C=O,,[H-].[Na+],,val
US20080214663A1,CC(=O)O[C@H](C)[C@@H](C)OC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)OC(C)(C)C.Cl>>CC(=O)O[C@H](C)[C@@H](C)OC(=O)[C@@H](N)Cc1ccc(O)c(O)c1.Cl,,C1COCCO1,,,,val
US20040038939A1,COC(=O)c1c(O)cc(C(F)(F)F)nc1C(F)(F)F.O=C(Cl)N(c1ccccc1)c1ccccc1>>COC(=O)c1c(OC(=O)N(c2ccccc2)c2ccccc2)cc(C(F)(F)F)nc1C(F)(F)F,,CC#N,,CCN(CC)CC,,val
US20090221655A1,Cc1noc2cc(N3C[C@H](COS(C)(=O)=O)OC3=O)ccc12.[N-]=[N+]=[N-]>>Cc1noc2cc(N3C[C@H](CN=[N+]=[N-])OC3=O)ccc12,,CN(C)C=O,,CCOC(C)=O,O,val
US20120015988A1,CC(C)(C)c1cc(C(=O)NNC(=O)C(C)(C)S(=O)(=O)c2ccc(F)cc2)on1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)(C)c1cc(-c2nnc(C(C)(C)S(=O)(=O)c3ccc(F)cc3)s2)on1,,Cc1ccccc1,,,,val
US04634705,N#CCOc1cccc2c1CCC=C2>>N#CCOc1cccc2c1CCCC2,,CCO,,[BH4-].[Na+],,val
US20150152127A1,C=C(C)OC.CN(C(=O)OC(C)(C)C)C1=N[C@H]2[C@H](O[C@H]([C@@H](OCc3ccc(F)cc3)C(F)(F)F)[C@@H](O)[C@@H]2O)S1>>CN(C(=O)OC(C)(C)C)C1=N[C@H]2[C@H](O[C@H]([C@H](OCc3ccc(F)cc3)C(F)(F)F)[C@H]3OC(C)(C)O[C@@H]32)S1,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050043309A1,O=C1CCc2ccc(C=CCCCN3CCN(c4cccc5c4CCCC5)CC3)nc2N1>>O=C1CCc2ccc(CCCCCN3CCN(c4cccc5c4CCCC5)CC3)nc2N1,[Ni],C1CCOC1,CCOCC,Cl,,val
US20070208054A1,CNCc1cccc([N+](=O)[O-])c1.O=C(OCc1ccccc1)ON1C(=O)CCC1=O>>CN(Cc1cccc([N+](=O)[O-])c1)C(=O)OCc1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160194304A1,CNc1ccc(OCc2ccccc2)cc1.O=C(O)c1ccn2c1CCCC2>>CN(C(=O)c1ccn2c1CCCC2)c1ccc(OCc2ccccc2)cc1,,Cc1ccccc1,ClCCl,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20020165229A1,CN(C)CC[O-].N#Cc1cnc2cnc(F)cc2c1Nc1ccc(Cl)cc1F>>CN(C)CCOc1cc2c(Nc3ccc(Cl)cc3F)c(C#N)cnc2cn1,,C1CCOC1,,O,,val
US20120053195A1,Br.Cc1cc(Nc2nc(C(O)c3ccc(F)cc3)nc3ccccc23)n[nH]1>>Br.Cc1cc(Nc2nc(C(O)c3ccc(F)cc3)nc3ccccc23)n[nH]1,,CCO,,,,val
US20060199783A1,CCN(CC)S(F)(F)F.CCOC(=O)[C@@](C)(O)[C@H](OC(=O)c1ccccc1)[C@H]1COC(C)(C)O1>>CCOC(=O)[C@](C)(F)[C@H](OC(=O)c1ccccc1)[C@H]1COC(C)(C)O1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US04409228,CC(=O)NC1CCN(c2cccc(Cl)n2)CC1>>NC1CCN(c2cccc(Cl)n2)CC1,,Cl,,,,val
US20080312248A1,COc1cc(NC(C)=O)c(Cl)c(C(F)(F)F)c1Cl>>COc1cc(N)c(Cl)c(C(F)(F)F)c1Cl,,CCO,O,[K+].[OH-],,val
US20160115125A1,CCOC(=O)c1[nH]ccc1F.CI>>CCOC(=O)c1c(F)ccn1C,,CN(C)C=O,,Cl,[H-].[Na+],val
US20080262021A1,BrBr.Nc1cc(F)ccc1C(=O)O>>Nc1cc(F)c(Br)cc1C(=O)O,,CO,,,,val
US04642308,COc1ccc(C(=O)O)cc1.Nc1ccc2ccc(Oc3ccccc3Cl)nc2n1>>COc1ccc(C(=O)Nc2ccc3ccc(Oc4ccccc4Cl)nc3n2)cc1,,O,,CCO,,val
US05093356,CC1Cc2ccccc2C1=O.CSc1ccc(CCl)cc1>>CSc1ccc(CC2c3ccccc3C(=O)C2C)cc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20070123505A1,CC(C)(F)[C@H](c1cc(F)cc(C(=O)NN)c1)C1CN([C@@H](c2ccc(Cl)cc2)c2cccc(C#N)c2)C1.CCOC(OCC)OCC>>CC(C)(F)[C@H](c1cc(F)cc(-c2nnco2)c1)C1CN([C@@H](c2ccc(Cl)cc2)c2cccc(C#N)c2)C1,,Cc1ccccc1C,,,,val
US05733913,N#Cc1cnc(Nc2ccccc2)nc1N.O=CO>>Nc1nc(Nc2ccccc2)ncc1C=O,[Ni],O,,,,val
US20030069434A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCCCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>Cc1ccc(S(=O)(=O)OCCCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc1,,c1ccncc1,,O,,val
US20110144084A1,COc1ccc(C=O)cc1.N[C@@H](CO)c1ccccc1>>COc1ccc(/C=N/[C@@H](CO)c2ccccc2)cc1,,Cc1ccccc1,,,,val
US20030229089A1,Brc1cncc(Br)c1.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1cc(Br)cc(Br)c1,,ClCCl,,,,val
US20130210801A1,Cc1ccc2c(Br)c(O)c(Cl)cc2n1.OB(O)c1ccc(Cl)cc1>>Cc1ccc2c(-c3ccc(Cl)cc3)c(O)c(Cl)cc2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20120245161A1,Cc1cccc2c(C(=O)C(F)(F)F)cn(CCN3CCOCC3)c12.[OH-]>>Cc1cccc2c(C(=O)O)cn(CCN3CCOCC3)c12,,O,,Cl,,val
US20100297020A1,CCOP(=O)(COc1c(-c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)oc2ccccc2c1=O)OCC>>CCOP(=O)(COc1c(-c2ccc(O)c(O)c2)oc2ccccc2c1=O)OCC,[Pd],CCO,,[H][H],,val
US20050043388A1,NNC(=O)COc1ccc(-c2nnn[nH]2)cc1.O=C1Nc2ccc(Br)cc2C1=O>>O=C(COc1ccc(-c2nnn[nH]2)cc1)NN=C1C(=O)Nc2ccc(Br)cc21,,CC(=O)O,,,,val
US20090270363A1,CN(C)c1ccc(C#N)cc1.S>>CN(C)c1ccc(C(N)=S)cc1,,c1ccncc1,,CCN(CC)CC,,val
US20070054935A1,Cc1cc(C)c([Mg]Br)c(C)c1.N#Cc1cccc(-c2ccncc2C=O)c1>>Cc1cc(C)c(C(O)c2cnccc2-c2cccc(C#N)c2)c(C)c1,,C1CCOC1,,,,val
US20080293940A1,Cc1oc(=O)oc1CCl.[Br-]>>Cc1oc(=O)oc1CBr,,CC(C)=O,,CN(C)C=O,,val
US04824830,C=C1C2=CC(=O)C[C@@H](C)[C@]2(C)[C@H]2CC[C@]3(C)C(=O)[C@H](F)C[C@H]3[C@@H]2[C@@H]1C>>C=C1C2=CC(=O)C=C(C)[C@]2(C)[C@H]2CC[C@]3(C)C(=O)[C@H](F)C[C@H]3[C@@H]2[C@@H]1C,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20040186091A1,C=O.c1ccc(N2CCC(c3nnc4n3-c3ccccc3CNC4)CC2)nc1>>CN1Cc2ccccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04205080,CCOC(=O)c1cc2cc(-c3ccccc3)ccc2o1>>O=C(O)c1cc2cc(-c3ccccc3)ccc2o1,,[K+],[OH-],,,val
US20110118257A1,CC(c1oc2ccccc2c(=O)c1-c1cccc(F)c1)n1nc(-c2ccc(CNC(=O)OC(C)(C)C)s2)c2c(N)ncnc21>>CC(c1oc2ccccc2c(=O)c1-c1cccc(F)c1)n1nc(-c2ccc(CN)s2)c2c(N)ncnc21,,ClCCl,O=C(O)C(F)(F)F,,,val
US20160272602A1,CCOC(=O)C(=O)c1cc(C(F)(F)F)ccc1CN1CCN(C(=O)OC(C)(C)C)CC1>>CC(C)(C)OC(=O)N1CCN(Cc2ccc(C(F)(F)F)cc2C(=O)C(=O)O)CC1,,O,,C1CCOC1,[Li+].[OH-],val
US20110245249A1,CC(=O)c1cccc(N)c1.Clc1ncc(Cl)c(NC2CC2)n1>>CC(=O)c1cccc(Nc2ncc(Cl)c(NC3CC3)n2)c1,,C1COCCO1,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20040242659A1,CC(C)(C)Oc1ccc(CCCCO)cc1.CS(=O)(=O)Cl>>CC(C)(C)Oc1ccc(CCCCOS(C)(=O)=O)cc1,,CCOC(C)=O,,CCN(CC)CC,O,val
US20150018332A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC1(F)CN(C(c2ccccc2)c2ccccc2)C1>>CC(C)(C)OC(=O)NCC1(F)CN(C(c2ccccc2)c2ccccc2)C1,,ClCCl,,,,val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Nc1ccc(N2CCCC2)cc1>>COc1ccc2nc(Nc3ccc(N4CCCC4)cc3)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US20120077828A1,N#Cc1cccc(CC(=O)O)c1.Nc1nccc2scc(-c3ccc4c(c3)CCN4)c12>>N#Cc1cccc(CC(=O)N2CCc3cc(-c4csc5ccnc(N)c45)ccc32)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040072692A1,Fc1cccc(F)n1.Oc1csc(C(F)(F)F)c1>>Fc1cccc(Oc2csc(C(F)(F)F)c2)n1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050154061A1,CC(C)(C)OC(=O)C(C)(C)Sc1ccc(Br)cc1.CN(C)C=O>>CC(C)(C)OC(=O)C(C)(C)Sc1ccc(C=O)cc1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20070185155A1,BrCCCCOCc1ccccc1.OC(c1ccccc1)(c1ccccc1)C12CCN(CC1)CC2>>OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCCOCc3ccccc3)(CC1)CC2.[Br-],,CC#N,,,,val
US04608375,CI.O=c1[nH]c(=O)n(CCCBr)c2ccccc12>>Cn1c(=O)c2ccccc2n(CCCBr)c1=O,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20140179666A1,Brc1ccc2cc[nH]c2c1.CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C>>CC(C)[Si](C(C)C)(C(C)C)n1ccc2ccc(Br)cc21,,C1CCOC1,,[H-].[Na+],,val
US20110172230A1,O=C(Nc1ccc(OCc2ccccc2)nn1)Oc1ccccc1.O=C(c1cccc(OCCC2CCCCC2)c1)N1CCNCC1>>O=C(Nc1ccc(OCc2ccccc2)nn1)N1CCN(C(=O)c2cccc(OCCC3CCCCC3)c2)CC1,,CC#N,,CCOC(C)=O,Cl,val
US20160052888A1,O=C1N[C@@]2(CC[C@H](c3ccc4c(c3)CCC(O)C4)C2)CO1>>N[C@]1(CO)CC[C@H](c2ccc3c(c2)CCC(O)C3)C1,,C1COCCO1,,[Na+].[OH-],,val
US20040242494A1,CC(=O)OC(C)=O.CC[C@@H](C(=O)OC(C)(C)C)n1cccc(N)c1=O>>CC[C@@H](C(=O)OC(C)(C)C)n1cccc(NC(C)=O)c1=O,,ClCCl,,CCN(CC)CC,,val
US20110294812A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCC(C)c3ccnc(NC(=O)OC(C)(C)C)c3)c3ccccc23)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCC(C)c3ccnc(N)c3)c3ccccc23)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160046624A1,COC(=O)CCC(=O)O.Nc1ncc(Br)cc1C(=O)O.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COC(=O)CCNC(=O)Nc1ncc(Br)cc1C(=O)O,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,,val
US20030013721A1,CC(=O)Cl.Cc1ccccc1NC(=O)CN1C[C@H](C)N(S(=O)(=O)c2cccc(N)c2)[C@H](C)C1>>CC(=O)Nc1cccc(S(=O)(=O)N2[C@@H](C)CN(CC(=O)Nc3ccccc3C)C[C@H]2C)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080167286A1,CC(C)(C)OC(=O)c1cccc(-c2nc(-c3cccnc3)no2)c1>>O=C(O)c1cccc(-c2nc(-c3cccnc3)no2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150110809A1,CCc1ccc[nH]1.Cc1ccccc1S(=O)(=O)Cl>>CCc1cccn1S(=O)(=O)c1ccccc1C,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20090298823A1,CCOC(=O)C1CCCNC1.Clc1nc(Cl)c2[nH]cnc2n1>>CCOC(=O)C1CCCN(c2nc(Cl)nc3[nH]cnc23)C1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080214641A1,COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)NC(=O)C(F)(F)F)c1>>C[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1cccc(O)c1,,Cc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05292887,CCC1(c2c[nH]cn2)Cc2ccccc2C1=O.ClCc1ccc(Cl)cc1>>CCC1(c2cn(Cc3ccc(Cl)cc3)cn2)Cc2ccccc2C1=O,,CCOC(C)=O,,,,val
US20100216779A1,CC(C)(C)C1CC(CCS(C)(=O)=O)CCN1C(=O)[O-].Cl>>CS(=O)(=O)CCC1CCNCC1.Cl,,CO,,,,val
US20050272797A1,Cc1ccc(S(=O)(=O)O)cc1.O=C(N[C@@H]1CNCC12CC2)OCc1ccccc1>>Cc1ccc(S(=O)(=O)O)cc1.O=C(N[C@@H]1CNCC12CC2)OCc1ccccc1,,Cc1ccccc1,,CCO,O,val
US20060148888A1,O=C(O)C(C(=O)O)(C(=O)O)C1CCOc2cc(S(=O)(=O)c3cccc(F)c3)ccc21>>O=C(O)CC1CCOc2cc(S(=O)(=O)c3cccc(F)c3)ccc21,,CC(=O)O,,,,val
US05594023,CCN(CC)C(=O)Nc1ccc(S(=O)(=O)Cl)cc1.NC1(c2ccccc2Cl)C(=O)Nc2ccc(Cl)cc21>>CCN(CC)C(=O)Nc1ccc(S(=O)(=O)N2C(=O)C(N)(c3ccccc3Cl)c3cc(Cl)ccc32)cc1,,CCCCCC,CCOC(C)=O,,,val
US20130109682A1,CC(=O)OC(C)=O.CC(C)(C)[Si](C)(C)O[C@H]1C(O)C[C@H](c2ccncc2[N+](=O)[O-])OC12CC2>>CC(=O)O[C@@H]1C[C@H](c2ccncc2[N+](=O)[O-])OC2(CC2)[C@H]1O[Si](C)(C)C(C)(C)C,,c1ccncc1,,,,val
US06080781,CCOc1ccc(C=O)cc1OC.O=c1ccoc2cc(O)ccc12>>CCOc1ccc(C=C2COc3cc(O)ccc3C2=O)cc1OC,,O,,CO,Cl,val
US20030225097A1,CC(C)(C)C(=O)Nc1ccc2sc3ccccc3c2c1.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)C(=O)Nc1ccc2c(c1)-c1ccccc1S2=O,,ClCCCl,,ClCCl,,val
US20110190280A1,CS(=O)(=O)CCN1CCN(c2ccc([N+](=O)[O-])cn2)CC1>>CS(=O)(=O)CCN1CCN(c2ccc(N)cn2)CC1,[Pt],CCO,,,,val
US04031232,CS(=O)(=O)c1ccc(O)cc1.Cn1c([N+](=O)[O-])cnc1CCl>>Cn1c([N+](=O)[O-])cnc1COc1ccc(S(C)(=O)=O)cc1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US05424435,CC(CO)CC(C)(C)C.[O-][n+]1c(Cl)cccc1Cl>>CC(COc1cccc(Cl)[n+]1[O-])CC(C)(C)C,,CS(C)=O,,[Na+].[OH-],,val
US20120040991A1,Cc1ccc(-c2nc(C)no2)c(C(=O)N2C[C@@H]3C[C@@H]3C[C@H]2CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)n1>>Cc1ccc(-c2nc(C)no2)c(C(=O)N2C[C@@H]3C[C@@H]3C[C@H]2CO)n1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100285957A1,CCN(C)C(OC)OC.Cc1cc(Oc2nc(C3(C)CC3)ns2)c(C)cc1N>>CCN(C)C=Nc1cc(C)c(Oc2nc(C3(C)CC3)ns2)cc1C,,CO,Cc1ccccc1,,,val
US20060166989A1,CC(C)(C)OC(=O)[C@@H](Cc1ccccc1)NC(=O)c1ccc2cc(OCc3ccccc3)ccc2c1>>O=C(N[C@H](Cc1ccccc1)C(=O)O)c1ccc2cc(OCc3ccccc3)ccc2c1,,C1COCCO1,Cl,,,val
US20030087908A1,Clc1ncnc(Cl)n1.FC(F)(F)c1ccc2c(c1)NCCC2>>FC(F)(F)c1ccc2c(c1)N(c1ncnc(Cl)n1)CCC2,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05859024,CON.O=C1C=CCCC=C1>>CON1C2CCC1CC(=O)C2,,CC(C)O,,CCN(C(C)C)C(C)C,Cl,val
US20080221197A1,CCI.CCNCC(C)(C)c1ccc([N+](=O)[O-])cc1>>CCN(CC)CC(C)(C)c1ccc([N+](=O)[O-])cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US09346797B1,CCOC(=O)C=CC(F)(F)[C@](N[S@](=O)C(C)(C)C)(c1ccccc1F)C(F)F>>CCOC(=O)CCC(F)(F)[C@](N[S@](=O)C(C)(C)C)(c1ccccc1F)C(F)F,[Pd],CCOC(C)=O,,,,val
US20060264415A1,CC(Cl)OC(=O)Cl.O=C(COCc1ccc(F)cc1)NCCC1CCN(Cc2ccccc2)CC1>>Cl.O=C(COCc1ccc(F)cc1)NCCC1CCNCC1,,ClCCl,,,,val
US20130059835A1,CCOc1c(C(C)n2ccc(=O)c3c(N)ncnc32)cc(Cl)c(C)c1C1CN(C(=O)OCc2ccccc2)C1>>CCOc1c(C(C)n2ccc(=O)c3c(N)ncnc32)cc(Cl)c(C)c1C1CNC1,[Pd],CO,,Cl,O,val
US20160102107A1,CC(=O)NNc1ncc(Br)cc1Br>>Cc1nnc2c(Br)cc(Br)cn12,,C1COCCO1,,CC(=O)O,,val
US20090029958A1,C1CC2(CCN1)OCCO2.O=CCCOCCc1ccccc1>>c1ccc(CCOCCCN2CCC3(CC2)OCCO3)cc1,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110009454A1,COc1ccccc1CCl.Nc1ncccc1C(=O)NCc1ccc(O)cc1>>COc1ccccc1COc1ccc(CNC(=O)c2cccnc2N)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20090111791A1,CC(C)(C)OC(=O)N1CCC(Oc2cccc(C#N)c2)CC1.Cl>>Cl.N#Cc1cccc(OC2CCNCC2)c1,,C1COCCO1,,,,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(F)c(OCCOC)cc1CC2C(C)C>>COCCOc1cc2c(cc1F)-c1cc(=O)c(C(=O)O)cn1C(C(C)C)C2,,CO,O,Cl,[Li+].[OH-],val
US20080090818A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=C1NS(=O)(=O)c2cc(Br)ccc21>>CC1(C)OB(c2ccc3c(c2)S(=O)(=O)NC3=O)OC1(C)C,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20150291554A1,COS(=O)(=O)OC.Cc1cc(Oc2ccc(C(=O)Cl)cc2)ccc1Cl.N#CCC#N>>COC(=C(C#N)C#N)c1ccc(Oc2ccc(Cl)c(C)c2)cc1,,C1CCOC1,,[H-].[Na+],,val
US06265434B1,COc1ccc(COC(=O)CC2CCCC2)cc1.O=S(=O)(c1ccccc1)C1ON1c1ccccc1>>COc1ccc(COC(=O)CC2CCCC2O)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20160194290A1,C=CC(C(C)(C)CCCO[Si](C)(C)C(C)(C)C)C(C)(C(=O)O)c1ccc(CCC(C)(C)C)c(Cl)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>C=CC(C(C)(C)CCCO[Si](C)(C)C(C)(C)C)C(C)(N=C=O)c1ccc(CCC(C)(C)C)c(Cl)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20060205731A1,CI.O=C1N[C@H](c2ncc(-c3cccc(Br)n3)s2)CO1>>CN1C(=O)OC[C@H]1c1ncc(-c2cccc(Br)n2)s1,,C1CCOC1,,CN(C)C=O,[H-].[Na+],val
US20080267884A1,CC(=O)Nc1c(I)c(N)c(I)c(C(=O)Cl)c1I.NCC(O)CO>>CC(=O)Nc1c(I)c(N)c(I)c(C(=O)NCC(O)CO)c1I,,C1CCOC1,,,,val
US08598161B2,CC(C)(C)OC(=O)NC1=N[C@@]2(c3cc(NC(=O)c4ccc(Br)cn4)ccc3F)OCC[C@H]2CS1>>NC(=O)c1ccc(Br)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080293767A1,CC(C)=NC(C)C.CCOC=C(C(=O)OCC)C(=O)OCC>>CCOC(=O)c1ccc(C)n(C(C)C)c1=O,,c1ccc(Oc2ccccc2)cc1,,,,val
US04304781,BrCc1ccccc1.c1ccc(CSc2ccccn2)cc1>>[Br-].c1ccc(CSc2cccc[n+]2Cc2ccccc2)cc1,,CCOCC,,,,val
US20130072487A1,CCOC(=O)c1c(O)n(Cc2ccc(OC)cc2OC)c(=O)n(Cc2ccccc2)c1=O>>CCOC(=O)c1c(O)[nH]c(=O)n(Cc2ccccc2)c1=O,,O,O=S(=O)(O)O,,,val
US05574044,C1CCOC1.CCOC(=O)N1CCC(Nc2ccc(C)cc2[N+](=O)[O-])CC1>>CCOC(=O)N1CCC(n2c(=O)[nH]c3cc(C)ccc32)CC1,[Pt],CCO,,,,val
US20090306066A1,Cc1nc(NNC(=O)[C@H](CC2CCCC2)CN(C=O)OC2CCCCO2)c(F)c(N2C[C@@H](O)C3(CC3)C2)n1>>Cc1nc(NNC(=O)[C@H](CC2CCCC2)CN(O)C=O)c(F)c(N2CC(O)C3(CC3)C2)n1,,CC(=O)O,O,,,val
US20120190701A1,O=C(O)c1cc(F)c(F)cc1Br>>OCc1cc(F)c(F)cc1Br,,CCOCC,,C1CCOC1,,val
US20060148858A1,CI.Cc1nccc(CC(=O)O)c1OCc1ccccc1>>COC(=O)Cc1ccnc(C)c1OCc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20100048909A1,CCC[C@H]1O[C@@H]1C(=O)OC.NC1CC1>>CCC[C@H]1O[C@@H]1C(=O)NC1CC1,,CCOC(C)=O,,CCO,,val
US20130237501A1,COC(=O)c1c(-c2ccc(F)cc2)oc2cc([N+](=O)[O-])c(OC(C)C)cc12>>COC(=O)c1c(-c2ccc(F)cc2)oc2cc([N+](=O)[O-])c(O)cc12,,ClCCl,,ClB(Cl)Cl,,val
US04548926,C1COCCO1.CC(C)CCON=O.CN(C)C=O.NNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1>>CN1CCOCC1.[N-]=[N+]=NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1,,C1COCCO1,,Cl,,val
US20160083362A1,CCN1CC[C@@H](NCCc2cccc(F)c2)C1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCN1CC[C@@H](N(CCc2cccc(F)c2)C(=O)C(F)(F)F)C1,,ClCCl,,CCN(CC)CC,,val
US20120149573A1,CCOC=C(C(=O)OCC)C(=O)OCC.N=C(NCc1ccccc1)c1ccccc1>>CCOC(=O)c1cnc(-c2ccccc2)n(Cc2ccccc2)c1=O,,CCO,,,,val
US20110118230A1,CC(C)(C)OC(=O)Nc1cnc(Cl)c(Br)c1I>>Nc1cnc(Cl)c(Br)c1I,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110034507A1,CCOC(=O)c1ccc(-c2cc3ccc(OC)cc3s2)cc1>>CCOC(=O)c1ccc(-c2cc3ccc(O)cc3s2)cc1,,ClCCl,,BrB(Br)Br,,val
US03937840,CCOc1ccccc1N.Cc1ccccc1C(=O)O>>CCOc1ccccc1NC(=O)c1ccccc1C,,CC(C)=O,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20090239854A1,C=Cc1cnc(C)cn1.CCc1ccc2[nH]c3c(c2c1)CN(C)CC3>>CCc1ccc2c(c1)c1c(n2CCc2cnc(C)cn2)CCN(C)C1,,CN1CCCC1=O,O,[K+].[OH-],,val
US04666899,CCC#C/C=C\C1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](NC(=O)/C(=N\OCC(=O)OC(C)(C)C)c3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)[C@H]2SC1.Cl>>CCC#C/C=C\C1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)/C(=N\OCC(=O)O)c3csc(N)n3)[C@H]2SC1.Cl,,O=CO,,,,val
US05049559,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1nnc2n1-c1sc3c(c1C(c1ccccc1Cl)=NC2)CCN(C(=O)CSC(C)C)C3>>Cc1nnc2n1-c1sc3c(c1C(c1ccccc1Cl)=NC2)CCN(C(=S)CSC(C)C)C3,,Cc1ccccc1,,,,val
US20150353553A1,CC(C)c1ccnc(CO)c1>>CC(C)c1ccnc(C=O)c1,O=[Mn]=O,C1CCOC1,,,,val
US20040209921A1,CC(C)(C)OC(=O)n1c(CCl)nc2ccccc21.CC(NCCCCNC(=O)OC(C)(C)C)c1ccccn1>>CC(c1ccccn1)N(CCCCNC(=O)OC(C)(C)C)Cc1nc2ccccc2n1C(=O)OC(C)(C)C,,CC#N,,CCN(C(C)C)C(C)C,,val
US20100009958A1,COC(OC)N(C)C.N#Cc1cc([N+](=O)[O-])ccc1N>>CN(C)C=Nc1ccc([N+](=O)[O-])cc1C#N,,C1COCCO1,,,,val
US20060235013A1,CCOC(=O)c1n[nH]c2c1CN(C(=O)Nc1c(CC)cccc1CC)C2>>CCc1cccc(CC)c1NC(=O)N1Cc2[nH]nc(C(=O)O)c2C1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20090197878A1,CCC/C(=C\C(N)=O)c1ccc2c(c1)C1(CCCCC1)OC(=O)N2>>CCC/C(=C\C#N)c1ccc2c(c1)C1(CCCCC1)OC(=O)N2,,C1COCCO1,,O=S(Cl)Cl,,val
US20060089349A1,CC1(C)CC2CC(C)(CN2C(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)C1.O=C(CCl)N1CCOCC1>>CC1(C)CC2CC(C)(CN2C(=O)c2ccc(NCC(=O)N3CCOCC3)cc2)C1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20040034046A1,COc1cc2c(Nc3c(Cl)ccc4c3OCO4)ncnc2cc1OCCCN1CCN(C(=O)OC(C)(C)C)CC1.ClCCl>>COc1cc2c(Nc3c(Cl)ccc4c3OCO4)ncnc2cc1OCCCN1CCNCC1.Cl.Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140044692A1,CCCCCC#CC=O>>CCCCCC#CCO,,CCO,O,,,val
US06797726B1,CC(C)(C)[O-].CCOC(C)=O.CN(C)C=O.OCCc1ccc2sccc2c1>>O=C(COCCc1ccc2sccc2c1)N1CCCCC1,,O,,Cl,,val
US20090099161A1,C1COCCN1.CCOCc1nc2c(N)nc3cc(CCCOS(C)(=O)=O)ccc3c2n1CC(C)(C)O>>CCOCc1nc2c(N)nc3cc(CCCN4CCOCC4)ccc3c2n1CC(C)(C)O,,CC#N,,,,val
US20110015435A1,CCOC(=O)C(CCCCCCCCCCBr)C(=O)[O-].NC(N)=S>>O=C(O)C(CCCCCCCCCCS)C(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20040006081A1,CC(C)(C)OC(=O)NC1CCN(CCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1>>CNC1CCN(CCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060258721A1,CCN(C(=O)OC(C)(C)C)C1CCC(c2c[nH]c3ccc(N)cc23)CC1.CSC(=N)c1cccs1>>CCN(C(=O)OC(C)(C)C)C1CCC(c2c[nH]c3ccc(NC(=N)c4cccs4)cc23)CC1,,CCO,,I,,val
US20160207915A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.COc1cc(S(C)(=O)=O)ccc1N(C(=O)OCCl)c1nc2ccc(Cl)cn2n1>>COc1cc(S(C)(=O)=O)ccc1N(C(=O)OCOC(=O)C1CCN(C(=O)OC(C)(C)C)CC1)c1nc2ccc(Cl)cn2n1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20060135578A1,CCOP(=O)(CP(=O)(OCC)OCC)OCC.COc1cc(COc2nn(-c3ccccc3)cc2C=O)ccc1OCc1nc(-c2ccccc2)oc1C>>CCOP(=O)(/C=C/c1cn(-c2ccccc2)nc1OCc1ccc(OCc2nc(-c3ccccc3)oc2C)c(OC)c1)OCC,,O,,CN(C)C=O,[H-].[Na+],val
US20160136172A1,COc1cnc(Br)cc1C(=O)NCc1ccc(F)cc1>>O=C(NCc1ccc(F)cc1)c1cc(Br)ncc1O,,ClCCl,,BrB(Br)Br,CO,val
US04035422,CCC(=O)OC(=O)CC.Cc1ccc(N)c(C)c1O>>CCC(=O)Nc1ccc(C)c(O)c1C,,CCOC(C)=O,,,,val
US04153719,Cc1ccc(C=Cc2ccccc2)cc1.O=C1CCC(=O)N1Br>>BrCc1ccc(C=Cc2ccccc2)cc1,,ClC(Cl)(Cl)Cl,,,,val
US20110009454A1,CCCCCCCI.Nc1ncccc1C(=O)NCc1cccc(O)c1>>CCCCCCCOc1cccc(CNC(=O)c2cccnc2N)c1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20140038999A1,COC(=O)[C@H](COC(C)C)NC(=O)OCc1ccccc1>>CC(C)OC[C@@H](CO)NC(=O)OCc1ccccc1,,CC(C)O,,[BH4-].[Na+],,val
US20090275753A1,CC(=O)c1ccc(O)cc1.CC1=C2OC(C)(C)CC2C(COS(C)(=O)=O)C([N+](=O)[O-])=C1C>>CC(=O)c1ccc(OCC2C([N+](=O)[O-])=C(C)C(C)=C3OC(C)(C)CC32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20150291595A1,CC(C)(C)OC(=O)N[C@@H](CCOCc1ccccc1)c1nn2cccc2c(=O)n1-c1ccccc1>>CC(C)(C)OC(=O)N[C@@H](CCO)c1nn2cccc2c(=O)n1-c1ccccc1,[Pd],CO,,,,val
US20050288273A1,CC(=O)NC[C@H]1CN(c2cc3c(cc2F)C(=O)C(=CN(C)C)CCC3)C(=O)O1.NN>>CC(=O)NC[C@H]1CN(c2cc3c(cc2F)-c2[nH]ncc2CCC3)C(=O)O1,,CCO,,O,,val
US20130158075A1,CCOC(=O)CC1CCC(C(=O)NCC(=O)c2ccc([N+](=O)[O-])cc2)CC1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)CC1CCC(c2ncc(-c3ccc([N+](=O)[O-])cc3)s2)CC1,,C1COCCO1,CO,O=C([O-])O.[Na+],,val
US20140093522A1,C1CCOC1.CCOC(=O)C(O)c1ccc(N)cc1.OC1C=CCCCCC1.On1nnc2ccccc21>>CCOC(=O)C(O)c1ccc(NC(=O)OC2C=CCCCCC2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20060024330A1,NCc1ccc(F)cc1.O=[N+]([O-])c1cccnc1F>>O=[N+]([O-])c1cccnc1NCc1ccc(F)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080090802A1,COc1cc(-c2nc3ccc(N4CC(C)NCC(C)(C)C4)cc3c(=O)n2CC(=O)OC(C)(C)C)ccc1F>>COc1cc(-c2nc3ccc(N4CC(C)NCC(C)(C)C4)cc3c(=O)n2CC(=O)O)ccc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(C=O)ccc21.CC1CCNCC1>>CC1CCN(Cc2ccc3c(c2)cc(-c2ccc(Cl)c4c2C(=O)NC4)n3C(=O)OC(C)(C)C)CC1,,CC#N,O,CC(=O)O,O=C([O-])O.[Na+],val
US20090118281A1,CC(C)(CO)C[C@H]1COC(C)(C)N1C(=O)OC(C)(C)C.CS(=O)(=O)Cl>>CC(C)(COS(C)(=O)=O)C[C@H]1COC(C)(C)N1C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US05314886,CCCCCN1C[C@@H](C(=O)OC(C)(C)C)[C@@H](NC(=O)Nc2ccc(Cl)c(Cl)c2)C1=O>>CCCCCN1C[C@@H](C(=O)O)[C@@H](NC(=O)Nc2ccc(Cl)c(Cl)c2)C1=O,,O=C(O)C(F)(F)F,,,,val
US20160272592A1,COCc1ccc(C2CCC2)c(CN)c1.Cc1c(OC[C@H]2COC(C)(C)O2)nn(-c2ccccc2)c1N.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COCc1ccc(C2CCC2)c(CNC(=O)Nc2c(C)c(OC[C@H]3COC(C)(C)O3)nn2-c2ccccc2)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150158865A1,CN(C/C=C/C(=O)O)C1CC1.O=C(Cl)C(=O)Cl>>CN(C/C=C/C(=O)Cl)C1CC1,,ClCCl,,CN(C)C=O,,val
US05912258,CC(C)CBr.Nc1nnc(S)s1>>CC(C)CSc1nnc(N)s1,,CO,,[K+].[OH-],,val
US20090131431A1,CCn1ncc2c(NC3CCOCC3)c(CN)c(C)nc21.COC(=O)c1ccccc1CBr>>CCn1ncc2c(NC3CCOCC3)c(CN3Cc4ccccc4C3=O)c(C)nc21,,CC#N,ClCCl,CCN(C(C)C)C(C)C,,val
US20100239520A1,Cc1nc(-c2cnc(/C=C/Cc3ccccc3)cn2)sc1C(=O)NCc1ccccc1>>Cc1nc(-c2cnc(CCCc3ccccc3)cn2)sc1C(=O)NCc1ccccc1,[Pd],CCOC(C)=O,,,,val
US20070054928A1,COc1cc2c(Oc3ccc(N)cc3F)ccnc2cc1OCC1CC2CN(C)CC2C1.O=C(Cc1ccccc1)N=C=S>>COc1cc2c(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)ccnc2cc1OCC1CC2CN(C)CC2C1,,CCO,,Cc1ccccc1,,val
US20060089392A1,CCOC(=O)C1CCN(c2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)c(C(=O)N(C)C)c2)CC1>>CN(C)C(=O)c1cc(N2CCC(C(=O)O)CC2)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1,,CO,,[Na+].[OH-],,val
US20090075938A1,CC(=O)Cl.Nc1ccc(-c2nc3cc(Cl)ccc3o2)cc1>>CC(=O)Nc1ccc(-c2nc3cc(Cl)ccc3o2)cc1,,c1ccncc1,,O,,val
US20070249670A1,CC(CC=O)CC(C)(C)C.COC(=O)C(NC(=O)OCc1ccccc1)P(=O)(OC)OC>>COC(=O)/C(=C\CC(C)CC(C)(C)C)NC(=O)OCc1ccccc1,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US20030092720A1,C1COCCN1.Cc1ccc(S(=O)(=O)Oc2nc3cc(/C=C/c4nc(C(C)C)cs4)ccn3c(=O)c2/C=C/C(=O)OC(C)(C)C)cc1>>CC(C)c1csc(/C=C/c2ccn3c(=O)c(/C=C/C(=O)OC(C)(C)C)c(N4CCOCC4)nc3c2)n1,,CN(C)C=O,,,,val
US20120172351A1,CCC(=O)Cl.COC(=O)C[C@@H]1COc2cc(N(C(=O)C(F)(F)F)[C@@H]3COc4c(Nc5cc(OC)ccc5N)cccc43)ccc21>>CCc1nc2ccc(OC)cc2n1-c1cccc2c1OC[C@H]2N(C(=O)C(F)(F)F)c1ccc2c(c1)OC[C@H]2CC(=O)OC,,CC(=O)N(C)C,,O=C([O-])O.[Na+],,val
US20160137584A1,BrCCCCBr.OCCCOC1CCCCO1>>BrCCCCOCCCOC1CCCCO1,,C1CCOC1,,O,[H-].[Na+],val
US20120277205A1,C=CC(=O)OCc1cccc(Nc2cc(C)c(C)cc2I)c1>>Cc1cc2[nH]cc(C(=O)OCc3ccccc3)c2cc1C,,CN(C)C=O,,C1CN2CCN1CC2,,val
US20080070912A1,CC(C)C(=NO)c1c(-c2ccc(F)cc2)nn2ccccc12.C[Si](C)(C)N=C=O>>CC(C)C(=NOC(N)=O)c1c(-c2ccc(F)cc2)nn2ccccc12,,C1CCOC1,,c1ccncc1,,val
US05137920,ClCCCCCCCc1ccccc1.O=C(Cl)c1ccc(Cl)cc1>>O=C(c1ccc(Cl)cc1)c1ccc(CCCCCCCCl)cc1,,O=[N+]([O-])c1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20070155805A1,CCCCC(CCOc1ccc(CC(=O)OCC)cc1)c1sc2cc(C(F)(F)F)ccc2c1C>>CCCCC(CCOc1ccc(CC(=O)O)cc1)c1sc2cc(C(F)(F)F)ccc2c1C,,C1CCOC1,CO,[Na+].[OH-],,val
US20090181956A1,CCOC(=O)NN.O=c1[nH]c2ccccc2c(=O)o1>>CCOC(=O)NNC(=O)c1ccccc1N,,CCOC(C)=O,,CCO,,val
US04046772,CC(=O)OC(C)=O.NC(=O)c1nc2n(n1)-c1ccc(Cl)cc1C(c1ccccc1)=NC2O>>CC(=O)OC1N=C(c2ccccc2)c2cc(Cl)ccc2-n2nc(C(N)=O)nc21,,O,,c1ccncc1,,val
US20100152230A1,CCCCCc1cc(Cl)c([N+](=O)[O-])c(Cl)n1.NCC1CCOCC1>>CCCCCc1cc(NCC2CCOCC2)c([N+](=O)[O-])c(Cl)n1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20040097498A1,CCC(N)C(=O)O.CCCC(=O)Cl>>CCCC(=O)NC(CC)C(=O)O,,ClCCl,,CCN(CC)CC,[Na+].[OH-],val
US20030229079A1,BrC(Br)(Br)Br.COC(=O)c1cc(CO)ccn1>>COC(=O)c1cc(CBr)ccn1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20140371201A1,COc1ccc(CN(c2ccon2)S(=O)(=O)c2ccc3c(ccc(=O)n3-c3cc(F)c(-n4ccc(C)cc4=O)cc3OC)c2)cc1>>COc1cc(-n2ccc(C)cc2=O)c(F)cc1-n1c(=O)ccc2cc(S(=O)(=O)Nc3ccon3)ccc21,,O=C(O)C(F)(F)F,,,,val
US20130281490A1,C1CCOC1.C[C@H](O)[C@@H](N)C(=O)O.Cc1c(-c2ccc(-c3ccc(C(F)(F)F)cc3)cc2)ccn(C(=O)[O-])c1=O.O=C([O-])OC(c1ccc(-c2ccc(C(F)(F)F)cc2)cc1)c1ccccn1>>COC(=O)N(c1ccc(-c2ccc(C(F)(F)F)cc2)cc1)[C@@H](C(=O)O)[C@H](C)O,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20040229927A1,CO.NC(=O)c1ccc(-c2cnc(-c3ccc([N+](=O)[O-])cc3)[nH]2)cc1>>COC(=O)c1ccc(-c2cnc(-c3ccc([N+](=O)[O-])cc3)[nH]2)cc1,,CO,ClCCl,Cl,,val
US20130072677A1,CNC(=O)[C@@H](NC)C(=O)OC.O=C(Cl)c1ccc(I)cc1>>CNC(=O)C(C(=O)OC)N(C)C(=O)c1ccc(I)cc1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,Cl,val
US06090805,COC(=O)Cc1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1OCC(F)(F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(CC(=O)O)c(OCC(F)(F)C(F)(F)F)c2)CC1,,CO,,[Na+].[OH-],,val
US20140011853A1,COC(=O)C1(NC(=O)Cc2cc(-c3ccc(Cl)cc3)ccc2C)CCC(F)(F)CC1>>Cc1ccc(-c2ccc(Cl)cc2)cc1C1=C(O)C2(CCC(F)(F)CC2)NC1=O,,CC(=O)N(C)C,,Cl,CC(C)(C)[O-].[K+],val
US20160137595A1,COc1ccc(-c2cnc(Oc3cccc4c3CCCC4)c([N+](=O)[O-])c2C)cc1C(=O)O>>COc1ccc(-c2cnc(Oc3cccc4c3CCCC4)c(N)c2C)cc1C(=O)O,[Zn],CCO,ClCCl,O,[Cl-].[NH4+],val
US20060128790A1,CC(=O)Oc1c(C)c(C)c(O)c(C(C)=O)c1C.O=C1CCC1>>CC(=O)Oc1c(C)c(C)c2c(c1C)C(=O)CC1(CCC1)O2,C1CCNCC1,CCOC(C)=O,,,,val
US20040259910A1,CCOc1cccc(C(=O)c2ncc(C=O)c3cc(OCCO)c(OC)cc23)c1.O>>CCOc1cccc(C(=O)c2ncc(C(=O)O)c3cc(OCCO)c(OC)cc23)c1,,CC(C)(C)O,O,CC=C(C)C,[Na+].[O-]Cl,val
US20090048228A1,CNCCN(C)C.O=S(=O)(Cl)Cl>>CN(CC[NH+](C)C)S(=O)(=O)Cl.[Cl-],,ClC(Cl)Cl,,,,val
US20080138912A1,CCCCCCCCCCCCBr.Oc1cc(Br)c(O)cc1Br>>CCCCCCCCCCCCOc1cc(Br)c(O)cc1Br,,CCO,,[Na+].[OH-],,val
US20090291965A1,C=C(C)C.COC(=O)Cc1ccc(C(=O)O)cc1>>COC(=O)Cc1ccc(C(=O)OC(C)(C)C)cc1,,ClCCl,,O=S(=O)(O)O,,val
US20100041041A1,CC(C)(C)C(OC(=O)C1CC2CC[C@]1(C)C2(C)C)c1ccc(I)cc1[N+](=O)[O-]>>CC(C)C(OC(=O)C1CC2CC[C@]1(C)C2(C)C)c1ccc(I)cc1[N+](=O)[O-],,CO,,,,val
US20050245563A1,COC(=O)c1cc(O[Si](C)(C)C(C)(C)C)ccc1NC(=O)CC(C)=O>>CC(=O)c1c(O)c2cc(O[Si](C)(C)C(C)(C)C)ccc2[nH]c1=O,,CO,,C[O-].[Na+],,val
US20150038528A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#CCc1ccccc1F>>CC(C)(C)OC(=O)C(C#N)c1ccccc1F,,C1CCCCC1,C1CCOC1,CC(C)[N-]C(C)C.[Li+],,val
US20060160857A1,CCOC(=O)c1nc(C)sc1N.NS(=O)(=O)c1cccc(Br)c1>>CCOC(=O)c1nc(C)sc1Nc1cccc(S(N)(=O)=O)c1,,C1CCOC1,C1COCCO1,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20080249091A1,CCOC(=O)C(=Cc1ccc(OCc2ccccc2)cc1)N=[N+]=[N-]>>CCOC(=O)c1cc2ccc(OCc3ccccc3)cc2[nH]1,,Cc1ccccc1C,,,,val
US04871730,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.[N-]=[N+]=NCCO>>[N-]=[N+]=NCCOS(=O)(=O)C(F)(F)F,,ClCCl,,Cc1cccc(C)n1,,val
US20150361100A1,O=C1CCCN1c1c(CO)cc2ccccn12>>O=Cc1cc2ccccn2c1N1CCCC1=O,O=[Mn]=O,,,,,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4cccc(SC)c4)nc(Cl)c3n2)cc1.Nc1ccc(N2CCOCC2)cc1>>CSc1cccc(-c2nc(Nc3ccc(N4CCOCC4)cc3)c3[nH]ncc3n2)c1,C1COCCO1,CO,,Cl,,val
US20090054392A1,OC1CCN(c2nccc(-c3ccc4ccccc4c3)n2)CC1>>O=C1CCN(c2nccc(-c3ccc4ccccc4c3)n2)CC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05114927,CC(C)(C)OC(=O)NCC(F)(F)C(O)C(Cc1ccccc1)NC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NCC(F)(F)C(O)C(N)Cc1ccccc1,[Pd],CCO,,[H][H],,val
US04684652,CCOC(=O)c1nc(-c2ccccc2)nc2ccccc12.OCC1CCCNC1>>O=C(c1nc(-c2ccccc2)nc2ccccc12)N1CCCC(CO)C1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20120010183A1,CS(N)(=O)=O.O=C(O)c1ccc(Nc2cnc(OC(C(F)(F)F)C(F)(F)F)c(Cl)c2)cc1>>CS(=O)(=O)NC(=O)c1ccc(Nc2cnc(OC(C(F)(F)F)C(F)(F)F)c(Cl)c2)cc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20100047367A1,COC(=O)c1cc(Cl)cn1N.O=Cc1ccc(F)cc1>>COC(=O)c1cc(Cl)cn1N=Cc1ccc(F)cc1,,CO,,,,val
US04822729,CCCCCCCCCCCCC(Oc1ccc([N+](=O)[O-])cc1)C(=O)Cl.Nc1cc(O)c(NC(=O)c2ccccc2)cc1Cl>>CCCCCCCCCCCCC(Oc1ccc([N+](=O)[O-])cc1)C(=O)Nc1cc(O)c(NC(=O)c2ccccc2)cc1Cl,,C1CCOC1,,,,val
US20130090333A1,Cc1cc(C(F)(F)F)ccc1B(O)O.Fc1cccc(F)c1C1COc2cc(Br)ccc2N1>>Cc1cc(C(F)(F)F)ccc1-c1ccc2c(c1)OCC(c1c(F)cccc1F)N2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20150080588A1,CO[C@H]1COCCC1(OC)OC>>CO[C@H]1COCCC1=O,,O,,C1CCOC1,Cl,val
US20100094013A1,Cl.O=C(Cc1ccccc1F)C1CC1>>O=C(CCCCl)Cc1ccccc1F,,ClCCl,,O,,val
US20050038035A1,CC(C)(C)OC(=O)Nc1cccc(CCN2CCN(c3ccc(NC(=O)C4=C(c5ccc(C(F)(F)F)cc5)CCCC4)cc3)CC2)n1>>Nc1cccc(CCN2CCN(c3ccc(NC(=O)C4=C(c5ccc(C(F)(F)F)cc5)CCCC4)cc3)CC2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100120764A1,CN(C(=O)c1ccc2nonc2c1)C1CCC(=O)CC1.NO>>CN(C(=O)c1ccc2nonc2c1)C1CCC(=NO)CC1,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US20060100237A1,CC(C)(C)OC(=O)N1C[C@@H]2CC[C@H](Oc3cc(-c4ccccc4F)ccc3C#N)C[C@H]2C[C@H]1C(=O)O.CCCC[Sn](CCCC)(CCCC)N=[N+]=[N-].ClCCl>>Cl.O=C(O)[C@@H]1C[C@@H]2C[C@@H](Oc3cc(-c4ccccc4F)ccc3-c3nn[nH]n3)CC[C@H]2CN1,,C1CCOC1,,,,val
US20110212918A1,Cc1nnc(-c2cc(N)cnc2S(=O)(=O)Cl)o1.Nc1ccc2c(c1)B(O)OC2>>Cc1nnc(-c2cc(N)cnc2S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)o1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100298491A1,Cc1ccc(S(=O)(=O)O)cc1.OC12CC3CC(C1)CC(O)(C3)C2.Oc1cccc(O)c1>>Oc1ccc(C23CC4CC(C2)CC(c2ccc(O)cc2O)(C4)C3)c(O)c1,,O,,COCCOC,,val
US20020091089A1,N[C@H](CCC(=O)OCc1ccccc1)C(=O)O.[Br-]>>O=C(CC[C@@H](Br)C(=O)O)OCc1ccccc1,,O=S(=O)(O)O,,O=N[O-].[Na+],,val
US20160272651A1,CCc1cc(Br)cc(C)c1N.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCc1cc(Br)cc(C)c1N=C=O,,C1CCOC1,,,,val
US20080227782A1,C1CCNC1.COC(OC)N(C)C.Cc1nc2ccc([N+](=O)[O-])cc2o1>>O=[N+]([O-])c1ccc2nc(C=CN3CCCC3)oc2c1,,CN(C)C=O,,,,val
US04353827,O=C(O)[C@@H]1C[C@@H](O)CN1.O=c1[nH]c2cccc(Cl)c2c(=O)o1>>O=C1Nc2cccc(Cl)c2C(=O)N2C[C@H](O)C[C@@H]12,,CS(C)=O,,,,val
US20020025301A1,CC(=O)c1ccccc1OC(=O)c1ccc(C)cc1>>Cc1ccc(C(=O)CC(=O)c2ccccc2O)cc1,,c1ccncc1,,CC(=O)O,[K+].[OH-],val
US20130217666A1,ON=C1c2cc(Br)ccc2C2CC1C2>>O=C1NC2CC(C2)c2ccc(Br)cc21,,C1COCCO1,,O=S(Cl)Cl,,val
US04659362,CC(C)=O.COc1nc(OC)c(C=O)c(OC)n1>>COc1nc(OC)c(C=CC(C)=O)c(OC)n1,,O,,[Na+].[OH-],,val
US20100105744A1,CSCc1cccc2c(C(CCC#N)c3ccc4sccc4c3)c[nH]c12.O=C(OO)c1cccc(Cl)c1>>CS(=O)Cc1cccc2c(C(CCC#N)c3ccc4sccc4c3)c[nH]c12,,CCOC(C)=O,,CO,ClCCl,val
US20130225552A1,CC(C)(C(=O)O)c1cccnc1Cl.CC(C)(C)OC(=O)N[C@H]1C[C@H](N)C1>>CC(C)(C)OC(=O)N[C@@H]1C[C@@H](NC(=O)C(C)(C)c2cccnc2Cl)C1,,ClCCl,O,CCN(CC)CC,Cl,val
US20060205755A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)N1CCC(=C2c3ccccc3C=C(Br)c3cc(Cl)ccc32)CC1>>CC(C)(C)OC(=O)N1CCC(=C2c3ccccc3C=C(Br)c3cc(Cl)ccc32)CC1,,ClCCl,,Cl,[Na+].[OH-],val
US20090163494A1,CO.COC(OC)OC.O=Cc1ccc[se]1>>COC(OC)c1ccc[se]1,,CO,,[Cl-].[NH4+],,val
US20080004274A1,CCCCCCCBr.COC1(OC)C(=O)Nc2ccc(I)cc21>>CCCCCCCN1C(=O)C(OC)(OC)c2cc(I)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20070049618A1,CCCN=C=O.NCc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O>>CCCNC(=O)NCc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,,CC#N,,Cl,,val
US20070185168A1,CC(Br)C(=O)c1ccc2c(c1)SCC(=O)N2.OC1(c2cccs2)CCNCC1>>CC(C(=O)c1ccc2c(c1)SCC(=O)N2)N1CCC(O)(c2cccs2)CC1,,CN(C)C=O,,CCN(CC)CC,O,val
US04006245,CCCc1ccccc1OCCCOc1cccc(O/C(=C\C(=O)O)C(=O)O)c1CC>>CCCc1ccccc1OCCCOc1ccc2c(=O)cc(C(=O)O)oc2c1CC,,O,,O=S(=O)(O)O,O=C([O-])[O-].[Na+].[Na+],val
US06420427B1,CCN(CC)CC.CCOC(=O)c1ccc(I)cc1.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)c1ccc(-c2cc3ccccc3o2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,Cl,,val
US20140323475A1,CC(=O)CCl.Oc1ccc(Cl)cc1C1OCCO1>>CC(=O)COc1ccc(Cl)cc1C1OCCO1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140206663A1,CC1C(=O)NN=C2COc3ccc(C=C4CN(C(=O)OC(C)(C)C)C4)cc3N21>>CC1C(=O)NN=C2COc3ccc(CC4CN(C(=O)OC(C)(C)C)C4)cc3N21,[Pd],CO,,,,val
US20130116235A1,CC(C)(C)OC(=O)N1CCn2nc([N+](=O)[O-])cc2C1>>CC(C)(C)OC(=O)N1CCn2nc(N)cc2C1,[Pd],CO,,,,val
US20090170885A1,CC(C)(C)CC(=O)Cl.CCN(CC)CC.Nc1c(Cl)cc(Br)cc1C(F)(F)F>>Cc1cc(Br)cc(C)c1NC(=O)CC(C)(C)C,,CC#N,,O,,val
US06087380,CCCN(CCC(=O)OCC)C(=O)c1ccc2c(c1)nc(CSc1ccc(C(=N)N)cc1)n2C.Cl>>CCCN(CCC(=O)O)C(=O)c1ccc2c(c1)nc(CSc1ccc(C(=N)N)cc1)n2C.Cl,,CCO,,O,[Na+].[OH-],val
US04576956,CNc1cc(C)on1.ClCl>>CNc1noc(C)c1Cl,,ClC(Cl)(Cl)Cl,ClCCl,,,val
US06555563B1,CSc1ccc(N2CC(O)(C(F)(F)F)N=C2c2nnc(SC)s2)cc1>>CSc1ccc(-n2cc(C(F)(F)F)nc2-c2nnc(SC)s2)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20050159407A1,CC(C)(C)OC(=O)C(N)CC(=O)OCc1ccccc1.COc1ccc(S(=O)(=O)Cl)cc1>>COc1ccc(S(=O)(=O)NC(CC(=O)OCc2ccccc2)C(=O)OC(C)(C)C)cc1,,ClCCl,,CCN(CC)CC,O,val
US20020045613A1,CC(C)OB(OC(C)C)OC(C)C.Clc1nccc2ccc(Br)cc12>>OB(O)c1ccc2ccnc(Cl)c2c1,,C1CCOC1,,[Li]CCCC,,val
US20140221374A1,CC(C)(C)C(N)=S.O=C(CBr)c1ccncc1>>CC(C)(C)c1nc(-c2ccncc2)cs1,,CCO,,Br,,val
US20140045862A1,BrCc1ccccc1.O[C@H]1CCC[C@@H]1c1ccnn1C1CCCCO1>>c1ccc(CO[C@H]2CCC[C@@H]2c2ccnn2C2CCCCO2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20130150343A1,CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C.CC1(O)CCN(c2nnc3ccc(F)cn23)CC1>>CC(C)[Si](OC1(C)CCN(c2nnc3ccc(F)cn23)CC1)(C(C)C)C(C)C,,ClCCl,,CCN(CC)CC,,val
US04956465,CCOC(=O)CC#N.CCOC(=O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O>>CCOC(=O)c1cn(C2CC2)c2c(F)c(C(C#N)C(=O)OCC)c(F)cc2c1=O,,C1COCCO1,O,Cl,[H-].[Na+],val
US20160108039A1,CC(Cl)C(=O)N(Cc1ccccc1)C(C)(C)CO>>CC1OCC(C)(C)N(Cc2ccccc2)C1=O,,CC(C)O,,CC(C)(C)[O-].[K+],,val
US05847122,COC(=O)[C@@H]1O[C@H]1c1ccc(OC)cc1.Nc1ccccc1>>COc1ccc([C@@H]2O[C@H]2C(=O)Nc2ccccc2)cc1,,CS(C)=O,,O,[H-].[Na+],val
US20130040935A1,COC(=O)C1(N)CCC2(CC1)OCCO2.Cc1ccc(Br)cc1CC(=O)Cl>>COC(=O)C1(NC(=O)Cc2cc(Br)ccc2C)CCC2(CC1)OCCO2,,ClCCl,,CCN(CC)CC,,val
US20110275608A1,CCOC(=O)Cl.CN1CCOCC1.NCC1CCN(Cc2cc(-c3ccccc3)no2)CC1.O=C(O)c1ccc(Cl)c(O)c1>>CCOC(=O)Oc1cc(C(=O)NCC2CCN(Cc3cc(-c4ccccc4)no3)CC2)ccc1Cl.N,,CCOC(C)=O,ClCCl,,,val
US20120258950A1,CC(C)(C)OC(=O)NC(C(=O)O)c1ccc(Cl)cc1.CC(C)n1cc(C(=O)c2cncc(N)c2)c2cncnc21>>CC(C)n1cc(C(=O)c2cncc(NC(=O)C(NC(=O)OC(C)(C)C)c3ccc(Cl)cc3)c2)c2cncnc21,,c1ccncc1,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20140329799A1,Sc1nc2cc(Cl)ccc2s1>>Clc1ccc2scnc2c1,[Fe],CC(=O)O,,,,val
US20160229814A1,CCOC(=O)CC1Oc2cc([N+](=O)[O-])ccc2N(CC)C1=O>>CCOC(=O)CC1Oc2cc(N)ccc2N(CC)C1=O,[Pd],CO,,[H][H],,val
US20040122244A1,C1CCNCC1.COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)O)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)N3CCCCC3)c2)=C(C)C1=O,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20130040929A1,CC(C)(C)OC(=O)N1CCC(c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1>>Clc1ccc(-c2cc(C3CCNCC3)[nH]n2)cc1,,ClCCl,,Cl,,val
US20120277229A1,O=C(Nc1ccc2c(c1)c(-c1nc3ccccc3[nH]1)nn2C1CCCCO1)Nc1ccc(F)cc1F>>O=C(Nc1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1)Nc1ccc(F)cc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US04897490,CCOC=O.Cn1nnnc1C=C(c1ccc(F)cc1)c1ccc(F)cc1>>Cn1nnnc1C(C=O)=C(c1ccc(F)cc1)c1ccc(F)cc1,,C1CCOC1,,Cl,[Li]CCCC,val
US05342846,CS(=O)(=O)OC1CN(C(c2ccccc2)c2ccccc2)C1.[c-]1nc[nH]n1>>c1ccc(C(c2ccccc2)N2CC(n3cncn3)C2)cc1,,CN(C)C=O,,O,[K],val
US20040023968A1,O=C(O)CCCC(=O)Nc1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F>>O=C1CCCC(=O)N1c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05811459,CCOC(=O)c1cnc(CCc2ccccc2OCc2ccccc2)n(C)c1=O>>COC(=O)c1cnc(CCc2ccccc2OCc2ccccc2)n(C)c1=O,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100130447A1,COC(=O)c1cccc(C(C)NC(=O)OC(C)(C)C)c1>>COC(=O)c1cccc(C(C)N)c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20050250857A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)ON1C(=O)CCC1=O.CCCCCCCCN>>CCCCCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C,,CCOC(C)=O,,CCN(CC)CC,,val
US20050228044A1,CCOC(=O)C(CC)=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccccc1F>>CCOC(=O)/C(=C/c1ccccc1F)CC,,C1CCOC1,,,,val
US20040058942A1,CCCCCCCCCCCCCCCc1cccc(OCC)c1C=O.COC(=O)CC(C)=O.NC(N)=O>>CCCCCCCCCCCCCCCc1cccc(OCC)c1C1NC(=O)NC(C)=C1C(=O)OC,,C1CCOC1,,Cl,,val
US20130136782A1,CN(C)S(=O)(=O)n1cnc2ccc(C=Cc3ccccc3)cc21>>C(=Cc1ccc2nc[nH]c2c1)c1ccccc1,,CO,,Cl,[K+].[OH-],val
US20140296239A1,O=C(Cl)C(=O)Cl.O=C(O)c1cc(F)cc(Br)c1>>O=C(Cl)c1cc(F)cc(Br)c1,,ClCCl,,CN(C)C=O,,val
US20040235818A1,COCCN1CCC(C(=O)NO)(S(=O)(=O)c2ccc(Oc3ccc(OC(F)(F)F)cc3)cc2)CC1.O=C(O)C(O)C(O)C(=O)O>>COCCN1CCC(C(=O)NO)(S(=O)(=O)c2ccc(Oc3ccc(OC(F)(F)F)cc3)cc2)CC1.O=C(O)[C@H](O)[C@@H](O)C(=O)O,,CCOC(C)=O,,,,val
US20040102484A1,Cc1ccc(S(=O)(=O)CCOC(=O)COc2cc(C)cc(C(C)C)c2)cc1.O=S(=O)(O)Cl>>Cc1ccc(S(=O)(=O)CCOC(=O)COc2cc(C)c(S(=O)(=O)Cl)c(C(C)C)c2)cc1,,ClCCl,,,,val
US20150166574A1,CCOC(=O)Cc1cn2cc(-c3ccccc3)sc2n1>>OCCc1cn2cc(-c3ccccc3)sc2n1,,ClCCl,O,CC(C)C[AlH]CC(C)C,,val
US20130210809A1,CCOC(=O)c1cn(COC)nc1CO.O=S(=O)(Cl)c1ccccc1>>CCOC(=O)c1cn(COC)nc1COS(=O)(=O)c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20050020605A1,CCON=C(c1ccc(Br)cc1)C1CCN(C2(C)CCNCC2)CC1.Cn1cc(C(=O)O)c2ccccc21>>CCON=C(c1ccc(Br)cc1)C1CCN(C2(C)CCN(C(=O)c3cn(C)c4ccccc34)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05726306,COC(=O)C(C)CC(Cl)C(=O)O.O=S(Cl)Cl>>COC(=O)CCC(Cl)C(=O)Cl,,Cc1ccccc1,,,,val
US20010046993A1,N#CC1(CN2CCN(Cc3ccccc3)CC2)CCCCC1>>N#CC1(CN2CCNCC2)CCCCC1,,CO,,,,val
US20160137636A1,COc1cc(-c2ccccc2)ccc1B(O)O.O=S(=O)(Oc1c(F)c(F)c(F)c(F)c1F)c1ccc2c(Cl)nccc2c1>>COc1cc(-c2ccccc2)ccc1-c1nccc2cc(S(=O)(=O)Oc3c(F)c(F)c(F)c(F)c3F)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20130303524A1,O=[N+]([O-])c1cccc(F)c1-c1ccc(F)cc1>>Fc1ccc2c(c1)[nH]c1cccc(F)c12,,Clc1ccccc1Cl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090143396A1,COC(=O)Cc1cc(S(=O)(=O)N2C(C)CN(Cc3ccc(OC(F)(F)F)cc3)CC2C)ccc1C>>Cc1ccc(S(=O)(=O)N2C(C)CN(Cc3ccc(OC(F)(F)F)cc3)CC2C)cc1CC(=O)O,,C1CCOC1,CO,[Li+].[OH-],,val
US20110263556A1,CC(C)(C)C(=O)NCc1ccc(C(F)(F)F)c(C(=O)O)c1.Nc1ccc(OCC(F)F)c(C(=O)Nc2ccc(Br)cc2)c1>>CC(C)(C)C(=O)NCc1ccc(C(F)(F)F)c(C(=O)Nc2ccc(OCC(F)F)c(C(=O)Nc3ccc(Br)cc3)c2)c1,,C1CCOC1,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US05650533,O=[N+]([O-])c1cc(C(F)(F)F)ccc1C1(O)CC=NO1>>O=[N+]([O-])c1cc(C(F)(F)F)ccc1-c1ccno1,,O,,O=S(=O)(O)O,,val
US05498619,C1CCOC1.ClC(Cl)Cl.O.c1ccc(-c2ccsn2)cc1>>CCCC(O)c1cc(-c2ccccc2)ns1,,C1CCOC1,,,,val
US20040063679A1,CC(C)C(C)(C)CCO>>CC(C)C(C)(C)CC=O,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20060122210A1,Nc1cccc(-c2ccc(C(=O)N3CC[C@@]4(C3)OC(=O)c3ccccc34)c(Cl)c2)c1.O=C(Cl)CCCBr>>O=C1O[C@]2(CCN(C(=O)c3ccc(-c4cccc(N5CCCC5=O)c4)cc3Cl)C2)c2ccccc21,CN(C)c1ccncc1,C1CCOC1,,[H-].[Na+],,val
US20060211693A1,CCOC(=O)c1cc(S(=O)(=O)N(C)C)c(F)cc1OCC.CNC>>CCOC(=O)c1cc(S(=O)(=O)N(C)C)c(N(C)C)cc1OCC,,CN(C)C=O,O,,,val
US20100256188A1,CN(C)CCN.O=C(Nc1ccc(Br)cc1)c1ccc(F)c([N+](=O)[O-])c1>>CN(C)CCNc1ccc(C(=O)Nc2ccc(Br)cc2)cc1[N+](=O)[O-],,CCO,,O=C([O-])O.[Na+],,val
US20050054626A1,CCN(C(C)C)[C@@H]1CC[C@H](NC(=O)CN)[C@H](COC)C1.Clc1ccc2nc(Cl)nc(Cl)c2c1>>CCN(C(C)C)[C@@H]1CC[C@H](NC(=O)CNc2nc(Cl)nc3ccc(Cl)cc23)[C@H](COC)C1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080027080A1,CC(=O)N[C@@H]1C[C@H](N(C)C)CC[C@@H]1N1CC[C@H](N)C1=O.FC(F)(F)c1ccc2ncnc(Cl)c2c1>>CC(=O)N[C@@H]1C[C@H](N(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(C(F)(F)F)cc23)C1=O,,CC(C)O,,CCN(CC)CC,,val
US20150225449A1,C[C@H](N=[N+]=[N-])[C@H](NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1>>C[C@H](N)[C@H](NC(=O)OC(C)(C)C)C(=O)O,,CO,,,,val
US05352654,NS(=O)(=O)c1ncccc1F.S>>NS(=O)(=O)c1ncccc1S,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20150336928A1,COC(=O)NCC1(O)C(=O)N(C2CCN(C3Cc4cccc5cccc3c45)CC2)c2ccccc21.O=S(Cl)Cl>>COC(=O)NCC1(Cl)C(=O)N(C2CCN(C3Cc4cccc5cccc3c45)CC2)c2ccccc21,,ClCCl,,,,val
US20140235689A1,CN.Cc1nn(C)c(C(Cl)c2ccc(F)cc2F)c1-c1c(F)cccc1F>>CNC(c1ccc(F)cc1F)c1c(-c2c(F)cccc2F)c(C)nn1C,,CO,,,,val
US20110021636A1,Cl.NC(CO)(CO)CCc1ccc(Sc2cccc(OCc3ccccc3)c2)cc1Cl>>Cl.NC(CO)(CO)CCc1ccc(Sc2cccc(OCc3ccccc3)c2)cc1Cl,,O,,CCO,,val
US20100048568A1,CC(=O)Cn1nc(C)oc1=O.CNN>>CC(=O)NN1CC(C)=NN(C)C1=O,,CC(C)O,O,O=C(O)C(=O)O,,val
US20040019058A1,CC(C)(C)OC(=O)NCC=O.CC(C)(C)OC(=O)n1c(CNC2CCCc3cccnc32)nc2ccccc21>>CC(C)(C)OC(=O)NCCN(Cc1nc2ccccc2n1C(=O)OC(C)(C)C)C1CCCc2cccnc21,,ClCCl,,O=C([O-])O.[Na+],,val
US20160264518A1,COC(=O)/C=C/c1ccccc1NC(=O)c1ccccc1Br.COc1cc(F)ccc1O>>COC(=O)/C=C/c1ccccc1NC(=O)c1ccccc1Oc1ccc(F)cc1OC,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20040132727A1,COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.NC1CCN(Cc2ccccc2)CC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)NC4CCN(Cc5ccccc5)CC4)cc3)c2cc1OC,,ClC(Cl)Cl,O,CCN(CC)CC,,val
US20120214848A1,CC(C)Oc1ccc(-c2noc(-c3ccc(C(C)(C)NCCC(=O)O)cc3)n2)cc1Cl.CCO>>CC(C)Oc1ccc(-c2noc(-c3ccc(C(C)(C)NCCC(=O)O)cc3)n2)cc1Cl.CCO,,CCO,,,,val
US20140288040A1,CC(C)(C)OC(=O)NCc1ccc(F)c(O)c1F.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)NCc1ccc(F)c(Oc2ccc([N+](=O)[O-])cc2)c1F,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140249126A1,CCOC(=O)C(=CN(C)C)C(=O)c1cc(F)c(F)cc1F.NC1CC1>>CCOC(=O)c1cn(C2CC2)c2cc(F)c(F)cc2c1=O,,CCO,O,CCOCC,O=C([O-])[O-].[K+].[K+],val
US20100317643A1,COC(=O)CC(=O)C(C)C.NC(N)=S>>CC(C)c1cc(O)nc(S)n1,,CO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20080015208A1,N#C[O-].NCC1CCCc2cc(NS(=O)(=O)c3cccc(F)c3)ccc21>>NC(=O)NCC1CCCc2cc(NS(=O)(=O)c3cccc(F)c3)ccc21,,O,,Cl,,val
US04894386,CC(=O)OC(C)=O.CCCNC(=O)C(CC)C(O)c1ccc2c(c1)c(Cc1ccc(C(=O)OC)cc1OC)cn2CCC>>CCCNC(=O)C(CC)C(OC(C)=O)c1ccc2c(c1)c(Cc1ccc(C(=O)OC)cc1OC)cn2CCC,,CCOC(C)=O,,CCN(CC)CC,ClCCl,val
US20100317657A1,CI.Cc1nn(C)cc1-n1c(=O)n(C)c2cnc3ccc(-c4cnc5[nH]ccc5c4)cc3c21>>Cc1nn(C)cc1-n1c(=O)n(C)c2cnc3ccc(-c4cnc5c(ccn5C)c4)cc3c21,CO,CN(C)C=O,,[H-].[Na+],,val
US20140275049A1,COC(=O)c1ccc(-c2cc(-c3cc(SC(C)C)cc(C(C)(C)C)c3)n(-c3ccc(C(=O)N4CCN(C)CC4)cc3)n2)cc1>>CC(C)Sc1cc(-c2cc(-c3ccc(C(=O)O)cc3)nn2-c2ccc(C(=O)N3CCN(C)CC3)cc2)cc(C(C)(C)C)c1,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US20150353553A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CC1=CCC(CO)CC1>>CC1=CCC(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC1,,O,,CN(C)C=O,c1c[nH]cn1,val
US20090093486A1,CNc1ccc(OC(F)(F)F)cc1.O=C=Nc1nc(OCC(F)(F)F)cc(OCC(F)(F)F)n1>>CN(C(=O)Nc1nc(OCC(F)(F)F)cc(OCC(F)(F)F)n1)c1ccc(OC(F)(F)F)cc1,,ClCCl,,,,val
US20120264735A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCC1CCCO1>>Cc1ccc(S(=O)(=O)OCC2CCCO2)cc1,,CCOCC,O,[K+].[OH-],,val
US20080182852A1,CC(C)N.O=c1[nH]c2ccccc2c(=O)o1>>CC(C)NC(=O)c1ccccc1N,,O,,,,val
US20090012075A1,CCOC(=O)c1cc2ccc(C(F)(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc2s1>>CCOC(=O)c1cc2ccc(C(F)C(=O)O)cc2s1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150344468A1,C/C(=N/NS(=O)(=O)c1ccc(C)cc1)c1csc(-c2ccc(CCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cn2)n1.COCn1c(=O)sc2cc(B(O)O)ccc21>>COCn1c(=O)sc2cc(C(C)c3csc(-c4ccc(CCO[Si](c5ccccc5)(c5ccccc5)C(C)(C)C)cn4)n3)ccc21,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20160264567A1,CC(C)(C)OC(=O)N1[C@H](C(=O)O)CCC12CC2.NCc1cc(-c2cnc(C(F)(F)F)nc2)ncn1>>CC(C)(C)OC(=O)N1[C@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)ncn2)CCC12CC2,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100204206A1,COC(OC)N(C)C.CSc1cccc(C(N)=O)c1>>CSc1cccc(C(=O)N=CN(C)C)c1,,CO,,,,val
US05183899,CCCCc1cc(C(=O)OCC)nn1Cc1ccc(-c2ccccc2C#N)cc1.[N-]=[N+]=[N-]>>CCCCc1cc(C(=O)OCC)nn1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20030045558A1,CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccc(Br)cc3)oc2C)cc1.OB(O)c1ccc(C(F)(F)F)cc1>>CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccc(-c4ccc(C(F)(F)F)cc4)cc3)oc2C)cc1,,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20020013460A1,CCOC(=O)c1cccnc1C.CN>>CNC(=O)c1cccnc1C,,CO,,,,val
US03931177,N#Cc1ccc(C(=O)CCC(=O)O)cc1OCc1ccccc1>>N#Cc1ccc(C(=O)CCC(=O)O)cc1O,,CC(=O)O,,Br,,val
US20070265265A1,O=C(Nc1nc(-c2cccc([N+](=O)[O-])c2)cs1)C1CCCN1C(=O)OCc1ccccc1>>Nc1cccc(-c2csc(NC(=O)[C@@H]3CCCN3C(=O)OCc3ccccc3)n2)c1,,CCO,CCOC(C)=O,Cl[Sn]Cl,,val
US20090270460A1,CC(C)[Si](Oc1ccc([N+](=O)[O-])c(F)c1)(C(C)C)C(C)C>>CC(C)[Si](Oc1ccc(N)c(F)c1)(C(C)C)C(C)C,,CCOC(C)=O,,,,val
US20030144297A1,O[C@H]1Cc2ccccc2[C@H]1Nc1nc(C2CC2)c(-c2ccc(Cl)cc2Cl)nc1C1CC1.[N-]=[N+]=N>>[N-]=[N+]=N[C@@H]1Cc2ccccc2[C@H]1Nc1nc(C2CC2)c(-c2ccc(Cl)cc2Cl)nc1C1CC1,,C1CCOC1,Cc1ccccc1,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06452039B1,CC(C)I.CCCCCCCCCC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCCCC(=O)O>>CCCCCCCCCC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCCCC(=O)OC(C)C,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20150307451A1,Br.Cc1ccc(C(=O)O)c(N)c1C>>Cc1c(Br)cc(C(=O)O)c(N)c1C,,CS(C)=O,,O,,val
US20120157439A1,CCCS(=O)(=O)N(c1cccc([N+](=O)[O-])c1Cl)S(=O)(=O)CCC>>CCCS(=O)(=O)Nc1cccc([N+](=O)[O-])c1Cl,,C1CCOC1,CO,[Na+].[OH-],,val
US20030069291A1,CN(C)c1cc(C#N)ccn1.NO>>CN(C)c1cc(C(N)=NO)ccn1,,CO,,Cl,[Na],val
US20120252830A1,CCOC(=O)C(C)C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)C(=O)NN.O=C(n1ccnc1)n1ccnc1>>CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)c1n[nH]c(=O)o1,,C1CCOC1,,,,val
US20120232051A1,COc1cc(F)c(F)cc1-c1ccncc1N(CCS(C)(=O)=O)C(=O)c1cc(C(F)(F)F)nc(C(F)(F)F)c1.COc1ncccc1B(O)O>>COc1ncccc1-c1ccncc1NCCS(C)(=O)=O,,CO,ClCCl,,,val
US20080045537A1,CN(Cc1nc2c(CCCO)cccc2[nH]1)C1CCCc2cccnc21>>CN(Cc1nc2c(CCC=O)cccc2[nH]1)C1CCCc2cccnc21,,ClCCl,,,,val
US20070161615A1,CCCc1ncc(C(C)=O)n1CC.CN(C)C=O>>CCCc1ncc(C(=O)C=CN(C)C)n1CC,,CN(C)C=O,,CC(=O)N(C)C,,val
US20160108039A1,CC(Cl)C(=O)N(Cc1ccccc1)C(CO)CCO>>CC1OCC(CCO)N(Cc2ccccc2)C1=O,,CC(C)O,,CC(C)(C)[O-].[K+],,val
US20100137612A1,CC(=O)c1ccc(C(=O)NCN2C=CC=CC2)c(C)c1.Cc1ccccc1.O=C(c1cc(Cl)cc(Cl)c1)C(F)(F)F>>Cc1cc(C(=O)CC(O)(c2cc(Cl)cc(Cl)c2)C(F)(F)F)ccc1C(=O)NCc1ccccn1,,Cc1ccccc1,,CCCCN(CCCC)CCCC,,val
US04337256,CCOC(=O)Cc1cccc2c(C(C)C)nccc12.CN>>CNC(=O)Cc1cccc2c(C(C)C)nccc12,,CCO,,,,val
US20030055263A1,COC(=O)c1ccc(C(=O)OC)c(NC(=O)c2nc(-c3ccc4ccccc4c3)cs2)c1>>O=C(O)c1ccc(C(=O)O)c(NC(=O)c2nc(-c3ccc4ccccc4c3)cs2)c1,,CO,,[K+].[OH-],,val
US20090124596A1,CN(C(=O)OC(C)(C)C)C1CCNCC1.O=Cc1ccc(-c2cccc(-n3c(=O)n([C@@H]4CC[C@H](NC(=O)c5cn6cc(F)ccc6n5)CC4)c(=O)c4cc(F)cnc43)c2)cc1>>CNC1CCN(Cc2ccc(-c3cccc(-n4c(=O)n([C@@H]5CC[C@H](NC(=O)c6cn7cc(F)ccc7n6)CC5)c(=O)c5cc(F)cnc54)c3)cc2)CC1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20130261107A1,O=C1c2sc(COc3ccccc3)nc2CCCN1Cc1ccccc1>>c1ccc(CN2CCCc3nc(COc4ccccc4)sc3C2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110118236A1,CCOC(=O)c1sc(SC)c(C(=O)OCC)c1CBr.CN>>CCOC(=O)c1sc(SC)c2c1CN(C)C2=O,,C1CCOC1,,CCO,O=C([O-])[O-].[K+].[K+],val
US20150232465A1,C[C@@H](O)CNCc1ccccc1.O=[N+]([O-])c1ccc(Br)nc1Br>>C[C@@H](O)CN(Cc1ccccc1)c1nc(Br)ccc1[N+](=O)[O-],,CCO,,CCN(CC)CC,,val
US20150344468A1,C=CC(C)(C)O.CC(c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(Br)cn2)n1>>CC(c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(CCC(C)(C)O)cn2)n1,,C1CCOC1,,B1C2CCCC1CCC2,[Na+].[OH-],val
US20090247579A1,CCn1c(=O)ccc2cc(O)ccc21.CI>>CCn1c(=O)ccc2cc(OC)ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140142081A1,COC(=O)Cc1ccc([N+](=O)[O-])cn1>>COC(=O)Cc1ccc(N)cn1,[Pd],CO,,,,val
US20080319005A1,CN1CCN(Cc2ccc(N)cc2C(F)(F)F)CC1.Cc1cc(-n2cnc3cccnc32)ccc1CC(=O)O>>Cc1cc(-n2cnc3cccnc32)ccc1CC(=O)Nc1ccc(CN2CCN(C)CC2)c(C(F)(F)F)c1,,CO,ClCCl,,,val
US06440957B1,CSC1=NCCN1N=Cc1ccccc1.Cl.N>>Cl.NC1=NCCN1N=Cc1ccccc1,,CO,,CC#N,,val
US20150087585A1,C[C@H]1CCN(c2ncc([N+](=O)[O-])c(N)n2)C[C@H]1C(=O)N1CCCC1>>C[C@H]1CCN(c2ncc(N)c(N)n2)C[C@H]1C(=O)N1CCCC1,[Pd],CCO,,[H][H],,val
US20080119466A1,C=C[Sn](CCCC)(CCCC)CCCC.Nc1ncnc2c1nc(I)n2-c1ccc(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1>>C=Cc1nc2c(N)ncnc2n1-c1ccc(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1,,CN(C)C=O,,,,val
US05424414,COC(=O)CC12CC3CC(CC(Br)(C3)C1)C2.O=C(O)CC12CC3CC(C1)CC(c1ccccc1)(C3)C2>>COC(=O)CC12CC3CC(C1)CC(c1ccccc1)(C3)C2,,c1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US06903118B1,O=C(C=Cc1cccnc1)NCCN1CCNCC1.O=S(=O)(Cl)c1ccc2ccccc2c1>>O=C(C=Cc1cccnc1)NCCN1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1,,ClCCl,,,,val
US04423058,CC(C)(C)n1cc(O)cn1.CCNC(=O)F>>CCNC(=O)Oc1cnn(C(C)(C)C)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050130973A1,CC1(C)OB(c2ccc(CBr)cc2)OC1(C)C.Oc1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12>>CC1(C)OB(c2ccc(COc3cc(C(F)(F)F)nc4c(C(F)(F)F)cccc34)cc2)OC1(C)C,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150150868A1,O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1.O=S(=O)(O)c1ccccc1>>O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1.O=S(=O)(O)c1ccccc1,,CCO,,ClCCl,,val
US05104990,CCOC(=O)C(C(=O)OCC)C(C)(C)C(C#N)(CCCN(C)C)c1cccc(OC)c1.Cl>>COc1cccc(C2(CCCN(C)C)C(=O)NC(=O)CC2(C)C)c1.Cl,,O,,O=S(=O)(O)O,,val
US05246948,CC(=O)Cl.c1ccc(CNCCCSc2ccncc2)cc1>>CC(=O)N(CCCSc1ccncc1)Cc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20070060754A1,CC(C)(C)OC(=O)N1CCC(O)CC1.CCCn1c(COCC)nc2cnc3cc(O)ccc3c21>>CCCn1c(COCC)nc2cnc3cc(OC4CCN(C(=O)OC(C)(C)C)CC4)ccc3c21,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090247507A1,CC(C)c1nc(CN2CCN(C(=O)OC(C)(C)C)CC2)co1.Nc1ncc(Br)c(Cl)c1[N+](=O)[O-]>>CC(C)c1nc(CN2CCN(c3c(Br)cnc(N)c3[N+](=O)[O-])CC2)co1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120202785A1,Cc1ccccc1B(O)O.O=Cc1sc2ccccc2c1Br>>Cc1ccccc1-c1c(C=O)sc2ccccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150344466A1,C#CCOC(C)c1ccccc1.CCOC(=O)C[N+](=O)[O-]>>CCOC(=O)c1cc(COC(C)c2ccccc2)on1,,ClC(Cl)Cl,,C1CN2CCN1CC2,,val
US20110076291A1,C[C@H]1CN(c2ccc3c(n2)-c2sc(-c4ncnn4-c4ccc(F)cc4F)cc2CCO3)C[C@@H](C)N1.FCCBr>>CCN1[C@@H](C)CN(c2ccc3c(n2)-c2sc(-c4ncnn4-c4ccc(F)cc4F)cc2CCO3)C[C@H]1C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060166990A1,CC(O)CC=O.Cc1ccc(N)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl>>Cc1ccc(NCCC(C)O)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl,,CO,,,,val
US20070208054A1,CCS(=O)(=O)c1ccc(NC(=O)CCCc2ccc(C(Nc3ccc(C#N)cc3)C(=O)O)cc2)cc1CNC(=O)OC(C)(C)C>>CCS(=O)(=O)c1ccc(NC(=O)CCCc2ccc(C(Nc3ccc(C#N)cc3)C(=O)O)cc2)cc1CN,,CCOC(C)=O,,Cl,,val
US06696110B1,CCC/C=C/C(=O)O.CCCCCc1nnc(-c2ccc(O)cc2)s1>>CCC/C=C/C(=O)Oc1ccc(-c2nnc(CCCCC)s2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20040157858A1,CNCc1cc(F)cc(F)c1.Cc1cc(F)ccc1[C@H]1CN(C(=O)OC(C)(C)C)CCN1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cc(F)ccc1[C@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)N(C)Cc1cc(F)cc(F)c1,,ClCCl,,Cl,,val
US04977165,Cc1cccc(CCO)n1.O=C1NC(=O)c2ccccc21>>Cc1cccc(CCN2C(=O)c3ccccc3C2=O)n1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040147543A1,CC1(C)OC(=O)CC(=O)O1.CCOC(OCC)OCC.CO.Nc1ccc(Cc2ccccc2)cc1.Nc1cccc(Cc2ccccc2)c1>>CC1(C)OC(=O)C(=CNc2ccc(Cc3ccccc3)cc2)C(=O)O1.CC1(C)OC(=O)C(=CNc2cccc(Cc3ccccc3)c2)C(=O)O1,,CO,,,,val
US08450319B2,CCOC(=O)c1c(B2OC(C)(C)C(C)(C)O2)cn(COCc2ccccc2)c1C=O.Fc1ccccc1CBr>>CCOC(=O)c1c(Cc2ccccc2F)cn(COCc2ccccc2)c1C=O,,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20140336388A1,O=c1oc(C2CCN(c3ccc(/N=C/c4ccc([N+](=O)[O-])o4)cc3F)CC2)nn1Cc1ccccc1>>O=c1oc(C2CCN(c3ccc(NCc4ccc([N+](=O)[O-])o4)cc3F)CC2)nn1Cc1ccccc1,CC(=O)O,CO,,[BH3-]C#N.[Na+],,val
US05885986,NC(=S)c1ncn2c1[C@@H]1CCCN1C(=O)c1c(Cl)cccc1-2.O=C(CCl)CCl>>O=C1c2c(Cl)cccc2-n2cnc(-c3nc(CCl)cs3)c2[C@@H]2CCCN12,,C1COCCO1,,,,val
US20120264923A1,CC(=CC(=O)OCC(O)CO)CCCC(C)CCCC(C)C.O>>CC(=CC(=O)OCC(O)CO)CCCC(C)CCCC(C)C.O,,O,,,,val
US20080146561A1,C[C@H](Nc1nc(Br)cnc1N)c1ccccc1.O=C(n1ccnc1)n1ccnc1>>C[C@@H](c1ccccc1)n1c(O)nc2ncc(Br)nc21,,C1CCOC1,,,,val
US04533731,Cl.Nc1n[nH]c2ccc(O)cc12>>Cl.Nc1n[nH]c2ccc(O)cc12,,CCO,,CCOCC,,val
US20140364432A1,CC(C)OC(=O)/N=N/C(=O)OC(C)C.O=C(c1ccccc1-c1ccccc1)N1C[C@H](O)C[C@H]1CO.O=C1NC(=O)c2ccccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1c2ccccc2C(=O)N1C[C@@H]1C[C@@H](O)CN1C(=O)c1ccccc1-c1ccccc1.O=P(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,,,val
US20150065464A1,CN(C)C=O.Nc1cccnn1>>CN(C)C=Nc1cccnn1,,CN(C)C=O,,CC(=O)N(C)C,,val
US20130096113A1,CCOC(=O)/C=C/c1ccc2c(c1)ncn2Cc1ccc2nc(N[C@@H]3CCCC[C@H]3O)sc2c1>>O=C(O)/C=C/c1ccc2c(c1)ncn2Cc1ccc2nc(N[C@@H]3CCCC[C@H]3O)sc2c1,,C1CCOC1,,[Li+].[OH-],,val
US20130131039A1,Clc1cc2nccn2c(-c2cn[nH]c2)n1.N#CC=CC1CC1>>N#CCC(C1CC1)n1cc(-c2nc(Cl)cc3nccn23)cn1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20020049240A1,CNCCO.Clc1nc2ccccc2s1>>CN(CCO)c1nc2ccccc2s1,,O,,,,val
US20140315839A1,Nc1ccccn1.O=C(O)C(F)(F)F>>O=C(N=c1cccc[nH]1)C(F)(F)F,,ClCCl,,CCN(CC)CC,O,val
US20120322785A1,[O-][n+]1cc2cc(Cl)ncc2c(I)c1-c1ccccc1Cl>>Clc1cc2cnc(-c3ccccc3Cl)c(I)c2cn1,,ClCCl,,ClP(Cl)Cl,,val
US20140249196A1,C/C(=N\[S@@](=O)C(C)(C)C)c1ccc(Br)cc1>>C[C@H](N[S@@](=O)C(C)(C)C)c1ccc(Br)cc1,,C1CCOC1,O,[BH4-].[Na+],,val
US05753664,CSc1nc2c(ccn2Cc2ccc(C(=O)c3ccc(Cl)cc3)cc2)c(=O)n1C>>Cn1cnc2c(ccn2Cc2ccc(C(=O)c3ccc(Cl)cc3)cc2)c1=O,[Ni],CCO,COCCOC,CC(=O)O,,val
US20130079372A1,CNC(=O)c1ccc(NC(C)(C)C(=O)O)cc1F.N#Cc1ccc(N)cc1C(F)(F)F>>CNC(=O)c1ccc(NC(C)(C)C(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)cc1F,,ClCCl,,O,,val
US05552550,CCOC(=O)c1cc(O)c2c(OC(C)C)ccc(Br)c2c1.COS(=O)(=O)OC>>CCOC(=O)c1cc(OC)c2c(OC(C)C)ccc(Br)c2c1,,N,,CC(C)=O,,val
US20050222225A1,C#Cc1ccccc1.O=Cc1ccc2occ(Br)c2c1>>O=Cc1ccc2occ(C#Cc3ccccc3)c2c1,[Cu]I,C1CCOC1,,,,val
US20050197340A1,CSc1nc(Cl)c(C(O)C2CCCC2)c(Cl)n1>>CSc1nc(Cl)c(C(=O)C2CCCC2)c(Cl)n1,,CC(C)=O,,,,val
US20120270838A1,CCOC(=O)C(C)(C)Br.Oc1ccc(Cl)cc1Cl>>CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1Cl,,CC(=O)N(C)C,O,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20070004705A1,CCOC(=O)n1nc(N)c2c1C(C)(C)N(C(=O)OC(C)(C)C)C2.O=C(Cl)c1ccc(F)cc1>>CCOC(=O)n1nc(NC(=O)c2ccc(F)cc2)c2c1C(C)(C)N(C(=O)OC(C)(C)C)C2,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US04312876,C=CC#N.Cl.Fc1ccc(O[C@@H]2CCNC[C@H]2c2ccccc2)cc1>>Cl.N#CCCN1CC[C@@H](Oc2ccc(F)cc2)[C@H](c2ccccc2)C1,,CCOCC,,,,val
US20110152273A1,Br.COc1ccc(CN2Cc3c(F)c(N[C@@H]4CCCC[C@@H]4NC(=O)OC(C)(C)C)nc(Cl)c3C2=O)c(OC)c1>>N[C@H]1CCCC[C@H]1Nc1nc(Br)c2c(c1F)CNC2=O,,CC(=O)O,,,,val
US04559354,CC(C)I.COc1ccc(-c2nc(C(F)(F)F)c[nH]2)cc1>>COc1ccc(-c2nc(C(F)(F)F)cn2C(C)C)cc1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20050101623A1,COc1ccc2[nH]cc(C3CCNC3)c2c1.O=CC(=O)O>>COc1ccc2[nH]c3c(c2c1)C1CCN(C1)C3C(=O)O,,CO,O,,,val
US20050234041A1,CCN1C(=O)C(C(=O)OC(C)(C)C)CCc2ccc(OC)cc21.O=C1CCC(=O)N1Br>>CCN1C(=O)C(C(=O)OC(C)(C)C)CCc2cc(Br)c(OC)cc21,,CC(=O)O,ClC(Cl)Cl,,,val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccccc23)cc1.NCc1cccs1>>c1csc(CNc2nc3ccccc3c3c[nH]nc23)c1,C1COCCO1,CO,,Cl,,val
US20130116245A1,CCOC(=O)c1ccc[nH]1.O=C1CCC(=O)O1>>CCOC(=O)c1cc(C(=O)CCC(=O)O)c[nH]1,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20060183939A1,Cc1ccccc1O.O=C=O>>Cc1cccc(C(=O)O)c1O,,O,,[Na],,val
US20080146606A1,CC(C)(C)OC(=O)Cc1cc2c(Br)ccnc2[nH]1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C(O)Cc1cc2c(Br)ccnc2[nH]1,,ClCCl,,,,val
US20100022555A1,Cc1ccc(C(=O)N2CCNC[C@@H]2C)cn1.O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>Cc1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)C[C@@H]2C)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20140088111A1,CS(=O)(=O)Cl.O[C@@H]1CC[C@@H]1Oc1ccccc1C(F)(F)F>>CS(=O)(=O)O[C@@H]1CC[C@@H]1Oc1ccccc1C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20070032485A1,CCOC(=O)N1c2ccc(OS(=O)(=O)C(F)(F)F)nc2[C@@H](Nc2ncc(N3CCOCC3)cc2Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@H]1CC.CN>>CCOC(=O)N1c2ccc(NC)nc2[C@@H](Nc2ncc(N3CCOCC3)cc2Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@H]1CC,,C1CCOC1,CS(C)=O,CCN(CC)CC,,val
US20100331315A1,NS(=O)(=O)c1ccc(-c2ccc(C=O)o2)cc1.O=C1CNC(=O)N1>>NS(=O)(=O)c1ccc(-c2ccc(C=C3NC(=O)NC3=O)o2)cc1,,CCO,,C1CCNCC1,,val
US20160113928A1,CN(Cc1ccc(F)cc1C(F)(F)F)C1CCN(C(=O)OC(C)(C)C)C1>>CN(Cc1ccc(F)cc1C(F)(F)F)C1CCNC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110034445A1,CCCCCC(=O)Cl.Cn1ncnc1C(=NOCc1cccc(N)n1)c1ccccc1>>CCCCCC(=O)Nc1cccc(CON=C(c2ccccc2)c2ncnn2C)n1,,ClCCl,,,,val
US20070299085A1,CCOC(=O)CC(=O)c1ccc([N+](=O)[O-])c(C)c1.NN>>Cc1cc(C2=NNC(=O)C2)ccc1[N+](=O)[O-],,CCO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20090099155A1,N[C@@H]1CCc2ccccc21.O=C(N1CCc2ccc(Cl)c(OS(=O)(=O)C(F)(F)F)c2CC1)C(F)(F)F>>O=C(N1CCc2ccc(Cl)c(NC3CCc4ccccc43)c2CC1)C(F)(F)F,,Cc1ccccc1,,,,val
US05889010,O=[N+]([O-])c1cc(F)ccc1NCCCO>>Nc1cc(F)ccc1NCCCO,[Pd],CO,,,,val
US05672588,C[C@H](CN)Oc1ccccc1.O=C(OC[C@H]1O[C@@H](n2cnc3c(Cl)nc(Cl)nc32)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1)c1ccccc1>>C[C@H](CNc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)Oc1ccccc1,,C1COCCO1,,CCN(CC)CC,,val
US20130137672A1,CC(C)(C)OC(=O)N1CC[C@@H]2CN(C(=O)c3cccc(F)c3-n3nccn3)[C@@H]2C1>>O=C(c1cccc(F)c1-n1nccn1)N1C[C@H]2CCNC[C@H]21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070135452A1,CCCN(CCC)C(=O)c1cc([N+](=O)[O-])cc2nc(Nc3c(C)cc(C)cc3C)sc12>>CCCN(CCC)C(=O)c1cc(N)cc2nc(Nc3c(C)cc(C)cc3C)sc12,[Pd],CCO,,,,val
US05223498,Nc1cc(F)ccc1N1CCOCC1.S=C(Cl)Cl>>Fc1ccc(N2CCOCC2)c(N=C=S)c1,,C1COCCO1,O,,,val
US06180627B2,NC(=O)[C@H]1CCCN1C1CCCCC1>>NC[C@H]1CCCN1C1CCCCC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130102776A1,CC(C)(C)OC(=O)N1CCN(Cc2c(O)c(-c3ccccc3)cc3c2O/C(=C\c2c[nH]c4ccccc24)C3=O)CC1.Cl.ClCCl>>Cl.Cl.O=C1/C(=C/c2c[nH]c3ccccc23)Oc2c1cc(-c1ccccc1)c(O)c2CN1CCNCC1,,C1COCCO1,ClCCl,,,val
US20140371278A1,O=C(O)c1cc2snnc2c(F)c1Nc1ccc(Br)cc1Cl.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>O=c1[nH]c2cc3snnc3c(F)c2n1-c1ccc(Br)cc1Cl,,CC(C)(C)O,,CCN(CC)CC,,val
US05344845,CCCCCNCCCCC.COc1cc(C=CC(=O)N[C@@H]2CC[C@@H](C)CC2)ccc1OCCCl>>CCCCCN(CCCCC)CCOc1ccc(C=CC(=O)N[C@@H]2CC[C@@H](C)CC2)cc1OC,,CC(=O)CC(C)C,,,,val
US05595992,CC(C)C=C1CCC(N)CC1.COCc1ncnc(Cl)c1OC>>COCc1ncnc(NC2CCC(=CC(C)C)CC2)c1OC,,Cc1ccccc1,O,CCN(CC)CC,,val
US20160009683A1,COCOc1cccc(C(F)(F)C(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1>>O=C1CCC(N2Cc3cc(CNC(=O)C(F)(F)c4cccc(O)c4)ccc3C2=O)C(=O)N1,,C1COCCO1,,Cl,O=C([O-])O.[Na+],val
US20090233955A1,CN.O=C(O)c1ccc(Br)cc1F>>CNc1cc(Br)ccc1C(=O)O,,C1CCOC1,,[Li]CCCC,,val
US20060063779A1,C1CCNC1.CS(=O)(=O)Cc1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)cc1OCCBr>>CS(=O)(=O)Cc1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)cc1OCCN1CCCC1,,CC#N,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04542142,CC(C)(C)OC(=O)[C@@H]1[C@H](/C=C\C(=O)Oc2ccccc2)C1(C)C>>CC1(C)[C@@H](/C=C\C(=O)Oc2ccccc2)[C@H]1C(=O)O,,Cc1ccccc1,,,,val
US20090137577A1,ClCc1ccc(Br)cc1.O=C1NCC(CCl)O1>>O=C1OC(CCl)CN1Cc1ccc(Br)cc1,,C1CCOC1,O,CN(C)C=O,[H-].[Na+],val
US20120214766A1,CCOC(=O)C1(NC(=O)c2nn(-c3ccc(F)cc3F)c3c2C[C@@H]2C[C@H]32)CCC1.N>>NC(=O)C1(NC(=O)C2NN(c3ccc(F)cc3F)C3=C2C[C@@H]2C[C@H]32)CCC1,,CO,,,,val
US20100068197A1,CC(C)(C)OC(=O)NCCN.COc1ccc(N(C)c2nc(Cl)nc3ccccc23)cc1OC>>COc1ccc(N(C)c2nc(NCCNC(=O)OC(C)(C)C)nc3ccccc23)cc1OC,,CC(C)O,,CCN(C(C)C)C(C)C,Cl,val
US20160176811A1,C=CCNC(=O)CCCBr.N[C@@H](CS)C(=O)O>>C=CCNC(=O)CCCSC[C@@H](N)C(=O)O,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20120129840A1,CCCC(Br)C(=O)OCC.CCOC(=O)CC(=O)OCC>>CCCC(C(=O)OCC)C(C(=O)OCC)C(=O)OCC,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20100233116A1,BrCc1ccccc1.CCOC(=O)c1sc(N2CCNC2=O)nc1C>>CCOC(=O)c1sc(N2CCN(Cc3ccccc3)C2=O)nc1C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04170704,C#CCOc1ccc(C)nc1.II>>Cc1ccc(OCC#CI)cn1,,O,,CO,[Na+].[OH-],val
US20140323477A1,CCn1c(=O)c(-c2ccc(S(=O)(=O)N(C)C)cc2C)cc2cnc(S(C)=O)nc21.CN1CCC(CCN)CC1>>CCn1c(=O)c(-c2ccc(S(=O)(=O)N(C)C)cc2C)cc2cnc(NCCC3CCN(C)CC3)nc21,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US06337305B1,COC(=O)CBr.Oc1ccc(Cc2ncc(C(F)(F)F)cc2Cl)c(Cl)c1Cl>>COC(=O)COc1ccc(Cc2ncc(C(F)(F)F)cc2Cl)c(Cl)c1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090247507A1,CC(C)(C)OC(=O)N1CCNCC1.Cc1nc(CCl)cs1>>Cc1nc(CN2CCN(C(=O)OC(C)(C)C)CC2)cs1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20060166955A1,CC(=O)OC(C)=O.C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)O[C@]12CC[C@@H](C)CO2>>CC(=O)C1=CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C,,CC(=O)O,CC(=O)OC(C)=O,,,val
US05622954,CC(C)(C=C(F)S(=O)(=O)c1ccccc1)c1ccc(Cl)cc1.CCCC[SnH](CCCC)CCCC>>CCCC[Sn](CCCC)(CCCC)C(F)=CC(C)(C)c1ccc(Cl)cc1,,C1CCCCC1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20030187014A1,CCOC(=O)CC(C)=O.Cc1cc(N)n(-c2ccccn2)n1>>Cc1cc(O)c2c(C)nn(-c3ccccn3)c2n1,,O,,[Na+].[OH-],,val
US20130029987A1,CC1(C)C=CC(=O)CC1>>CC1(C)C=CC(O)CC1,,CO,O,[BH4-].[Na+],,val
US06017919,CCCCCCC(C)(C)c1cc(-c2cccc(C=CC(=O)OC)c2)ccc1OC>>CCCCCCC(C)(C)c1cc(-c2cccc(C=CC(=O)O)c2)ccc1OC,,CO,,[Na+].[OH-],,val
US20090163464A1,C1CCN(C2CCNCC2)C1.Clc1nc2ccc(Br)cc2s1>>Brc1ccc2nc(N3CCC(N4CCCC4)CC3)sc2c1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US04018802,CCCCCC(CCCC(Br)CCCCCCC(=O)OCC)OC(C)=O.OCCS>>CCCCCC(CCCC(CCCCCCC(=O)OCC)SCCO)OC(C)=O,,CO,,[Na],,val
US20060205719A1,BrBr.CCOc1cnc2cccc(C(C)=O)c2c1>>COc1cnc2cccc(C(=O)CBr)c2c1,,CC(=O)O,O,Br,,val
US20120035214A1,CC(C)(C)OC(=O)N1CC[C@](O)(c2ccc(F)c(F)c2)[C@@H](c2onc(-c3cccc4ccccc34)c2Br)C1>>O[C@]1(c2ccc(F)c(F)c2)CCNC[C@@H]1c1onc(-c2cccc3ccccc23)c1Br,,ClCCl,,C1COCCO1,Cl,val
US20060247178A1,CC(C)(C)OC(=O)NCCCC1(c2cccc(O[Si](C)(C)C(C)(C)C)c2)SC(c2cc(F)ccc2F)=NN1C(=S)NN.COC(C)(OC)OC>>Cc1nnc(N2N=C(c3cc(F)ccc3F)SC2(CCCNC(=O)OC(C)(C)C)c2cccc(O[Si](C)(C)C(C)(C)C)c2)s1,Cc1ccc(S(=O)(=O)O)cc1,,,,,val
US05679678,CN(C)C(=O)CCl.Fc1ccc(-c2ccco2)cc1>>O=C(CCl)c1ccc(-c2ccc(F)cc2)o1,,C1CCOC1,,Cl,[Li]CCCC,val
US20080188528A1,CC(C)c1cccc(B(O)O)c1.OCc1ccccc1Br>>CC(C)c1cccc(-c2ccccc2CO)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20140163001A1,CCOC(=O)c1csc(-c2cnn(C(C)(C)C)c2-c2ccc(F)cc2)n1>>CC(C)(C)n1ncc(-c2nc(C(=O)O)cs2)c1-c1ccc(F)cc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20160016941A1,CC#N.Cc1ccc(N2CCNCC2)cc1.O=C1CCCO1.O=C1OC(CI)CC1(c1ccccc1)c1ccccc1.O=CO>>Cc1ccc(N2CCN(CCC3OC(=O)CC3(C)C)CC2)cc1.O=CO,,CC#N,,,,val
US20120202777A1,CCOC(=O)C(C)(CCc1ccc(O)cc1)S(C)(=O)=O.OC1CCCCC1>>CCOC(=O)C(C)(CCc1ccc(OCCC2CC2)cc1)S(C)(=O)=O,,C1CCOC1,O,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20160222011A1,O=C1CCC(=O)N1Cl.O=S(=O)(c1ccc(O)c2ncccc12)N1CCN(Cc2ccc(F)cc2)CC1>>O=S(=O)(c1cc(Cl)c(O)c2ncccc12)N1CCN(Cc2ccc(F)cc2)CC1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20120129842A1,CCOc1ccc(C(N)=O)cc1NC(N)=S.Cc1nc(N)sc1C(=O)CBr>>CCOc1ccc(C(N)=O)cc1Nc1nc(-c2sc(N)nc2C)cs1,,CCO,,,,val
US20150291597A1,O=C1c2ccccc2C(=O)N1Oc1ccc(F)cc1>>NOc1ccc(F)cc1,,CO,ClC(Cl)Cl,NN,O,val
US05545747,CCCCCC[C@@H](F)CO.Cc1ccc(S(=O)(=O)Cl)cc1>>CCCCCC[C@@H](F)COS(=O)(=O)c1ccc(C)cc1,,O,,c1ccncc1,,val
US20110230428A1,CON=C(CCC#N)c1ccc(Cl)c(Cl)c1.NO>>CON=C(CCC(=N)NO)c1ccc(Cl)c(Cl)c1,,CCO,,O=S(=O)(O)O,O=C([O-])[O-].[Na+].[Na+],val
US20040229900A1,CCN=C=O.c1ccc(CN2CC3CNCC(C3)C2)cc1>>CCNC(=O)N1CC2CC(CN(Cc3ccccc3)C2)C1,,ClCCl,,,,val
US20150018328A1,CC(C)(C)OC(=O)N1CCC(Nc2nc(NC3CCC(F)(F)C3)nc(-c3cccc(C(F)(F)F)n3)n2)C1>>FC1(F)CCC(Nc2nc(NC3CCNC3)nc(-c3cccc(C(F)(F)F)n3)n2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100197687A1,C1COCCN1.CCOC(=O)c1c(C=O)c2cc(-c3ccc(C(C)(C)C)cc3)ccc2n1-c1ccc(OC(C)C)cc1>>CCOC(=O)c1c(N2CCOCC2)c2c(C)c(-c3ccc(C(C)(C)C)cc3)ccc2n1-c1ccc(OC(C)C)cc1,,CO,O,CC(=O)O,[BH3-]C#N.[Na+],val
US05459138,Cc1cnc(O)c([N+](=O)[O-])c1.O=S(Cl)Cl>>Cc1cnc(Cl)c([N+](=O)[O-])c1,,CN(C)C=O,,,,val
US05763615,CC(C=O)n1nnc2ccc(Oc3cc(F)c(C(F)(F)F)c(Cl)c3)cc21.NNc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>CC(C=NNc1ccc([N+](=O)[O-])cc1[N+](=O)[O-])n1nnc2ccc(Oc3cc(F)c(C(F)(F)F)c(Cl)c3)cc21,,CCO,O,O=S(=O)(O)O,,val
US20120101086A1,Cc1c2c(nn1-c1nnc(-c3ccc(OC(C)C)c(Cl)c3)s1)CCN(CCC(=O)OC(C)(C)C)C2.O=C(O)C(F)(F)F>>Cc1c2c(nn1-c1nnc(-c3ccc(OC(C)C)c(Cl)c3)s1)CCN(CCC(=O)O)C2.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20100210635A1,CC(=O)NCc1ccccc1Oc1ccccc1CCC(=O)N1CCN(C(=O)OC(C)(C)C)C[C@H]1Cc1ccccc1>>CC(=O)NCc1ccccc1Oc1ccccc1CCC(=O)N1CCNC[C@H]1Cc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04897490,CCOC(=O)C(=C(c1ccc(F)cc1)c1ccc(F)cc1)c1nnn(C(C)(C)C)n1>>CC(C)(C)n1nnc(C(CO)=C(c2ccc(F)cc2)c2ccc(F)cc2)n1,,Cl,ClCCl,CC(C)C[Al+]CC(C)C.[H-],,val
US20140135393A1,CC(C)(C=NO)c1ccc2c(c1)OCO2>>CC(C)(C=NO)c1ccc(O)c(O)c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20110003836A1,BrCCC1CO1.Brc1ccc2[nH]c3ccc(Br)cc3c2c1>>Brc1ccc2c(c1)c1cc(Br)ccc1n2CCC1CO1,,CCOC(C)=O,CN(C)C=O,[K+].[OH-],,val
US04431564,Oc1ccc(-c2ccccc2)cc1>>O[C@@H]1CC[C@@H](c2ccccc2)CC1,[Ni],CCO,,[H][H],,val
US20140163009A1,CCOC(=O)[C@H]1[C@H](c2ccc(N)cc2)[C@H]1c1ccccc1.O=S(=O)(Cl)C1CC1>>CCOC(=O)[C@H]1[C@H](c2ccc(NS(=O)(=O)C3CC3)cc2)[C@H]1c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20090048251A1,ClCc1ccccn1.O=[N+]([O-])c1ccc2[nH]ncc2c1>>O=[N+]([O-])c1ccc2c(cnn2Cc2ccccn2)c1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20130310374A1,CC(C)(C#N)c1ccc(Nc2c([N+](=O)[O-])cnc3ccc(Br)cc23)cn1>>CC(C)(C#N)c1ccc(Nc2c(N)cnc3ccc(Br)cc23)cn1,[Ni],C1CCOC1,CO,[H][H],,val
US20090149488A1,CCOC(=O)Oc1c(OC)cc(Cl)c2c1CN1CCc3cc(OC)c(OCc4ccccc4)cc3C1C2>>CCOC(=O)Oc1c(OC)cc(Cl)c2c1CN1CCc3cc(OC)c(O)cc3C1C2,[Ni],,,,,val
US04996202,Cc1cc2c(cc1N)[C@@H](c1ccccc1)CN(C)CC2.O=C(O)/C=C\C(=O)O>>Cc1cc2c(cc1N)[C@@H](c1ccccc1)CN(C)CC2.O=C(O)/C=C\C(=O)O,,CC(C)O,,CN(C)C=O,,val
US03957805,CC(=O)C1CC1.COC(=O)c1ccncc1>>O=C(CC(=O)C1CC1)c1ccncc1,,c1ccccc1,,C[O-].[Na+],,val
US20090312338A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(C(O)C3CC[C@@H](N(Cc4ccccc4)Cc4ccccc4)C3)c(Cl)cnc21>>CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(C(=O)C3CC[C@@H](N(Cc4ccccc4)Cc4ccccc4)C3)c(Cl)cnc21,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20070072865A1,NCc1ccncc1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.O=C1OC(c2ccccc2)(c2ccccc2)C2CNCCN12>>O=C(NCc1ccncc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US04260761,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=C1COc2ccccc21>>O=C(O)Cc1cc2ccccc2o1,,Cc1ccccc1,,,,val
US20010053853A1,COc1ccc(CNc2cccc(CCCCC(=O)CP(=O)(OC)OC)n2)cc1.Cc1ncc(C=O)cn1>>COc1ccc(CNc2cccc(CCCCC(=O)C=Cc3cnc(C)nc3)n2)cc1,,C1CCOC1,,[Na+].[OH-],,val
US20060122399A1,CCI.Oc1cnc(Cl)cc1I>>CCOc1cnc(Cl)cc1I,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090186870A1,CC(C)(C)OC(=O)N1CC[C@H](OS(C)(=O)=O)C1.NC(=O)c1cc(O)ccc1Cl>>CC(C)(C)OC(=O)N1CC[C@H](Oc2ccc(Cl)c(C(N)=O)c2)C1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05049671,CCCCCO.Nc1nc(Cl)c2ncn([C@H]3C=C[C@@H](CO)C3)c2n1>>CCCCCOc1nc(N)nc2c1ncn2[C@H]1C=C[C@@H](CO)C1,,CCCCCO,,Cl,[H-].[Na+],val
US03978121,CCOCCC[Mg]Br.Clc1ccc2c(c1)C(Cl)c1ccccc1C=C2>>CCOCCCC1c2ccccc2C=Cc2ccc(Cl)cc21,,CCOCC,,Cl,,val
US20040058988A1,C=CCI.NS(=O)(=O)c1ccc(C(=O)O)cc1>>C=CCOC(=O)c1ccc(S(N)(=O)=O)cc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US06562809B1,Brc1ccc2[nH]ccc2c1.O=C(Cl)c1ccccc1>>O=C(c1ccccc1)c1ccc2[nH]ccc2c1,,C1CCOC1,,[Li]C(C)(C)C,,val
US20110077243A1,CCOC(=O)C(=O)CBr.Nc1ncc(Br)cc1Br>>Br.CCOC(=O)c1cn2cc(Br)cc(Br)c2n1,,C1CCOC1,,,,val
US20140113900A1,Fc1ccccc1Cc1nc(Br)c2cccnn12.N#C[Cu]>>N#Cc1nc(Cc2ccccc2F)n2ncccc12,,CS(C)=O,,,,val
US05763700,Brc1cccc(Oc2ccccc2)c1.CC(=O)OCC(F)=CC1(c2ccc3c(c2)OCO3)CC1>>FC(=CC1(c2ccc3c(c2)OCO3)CC1)Cc1cccc(Oc2ccccc2)c1,,C1CCOC1,,[Mg],,val
US20050070582A1,CN(C)C(=O)c1ccc(Oc2cc(Cl)cc(Cl)c2)c(S(=O)(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1.Cl>>CN(C)C(=O)c1ccc(Oc2cc(Cl)cc(Cl)c2)c(S(=O)(=O)N2CCNCC2)c1.Cl,,ClCCl,,C1COCCO1,,val
US20080125468A1,CC(C)C[Mg]Br.Cc1cc(C=O)cc(C)c1-c1ccc(C(F)(F)F)cc1>>Cc1cc(C(O)CC(C)C)cc(C)c1-c1ccc(C(F)(F)F)cc1,,C1CCOC1,,,,val
US20100222319A1,CCNc1cc(Cl)ccc1C(=O)O.NCCN1CCCCC1>>CCNc1cc(Cl)ccc1C(=O)NCCN1CCCCC1,,C1CCOC1,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20120059028A1,CCCC(C(=O)OC)c1c(C)nc2sc3c(c2c1-c1ccc(F)cc1)CCCC3>>CCCC(C(=O)O)c1c(C)nc2sc3c(c2c1-c1ccc(F)cc1)CCCC3,,CO,,[Na+].[OH-],,val
US20160016948A1,CC(C)(C)OC(=O)N1CC(F)C(O)C(F)C1>>OC1C(F)CNCC1F,,CO,Cl,,,val
US20060183790A1,COc1ccc(C(=O)CCC(=O)c2ccccc2)cc1.NCC(=O)O>>COc1ccc(-c2ccc(-c3ccccc3)n2CC(=O)O)cc1,,CC(=O)O,,,,val
US05977105,OB(O)c1ccc(F)cc1.O[C@H](CCc1cccnc1)COc1ccc(Br)cc1>>O[C@H](CCc1cccnc1)COc1ccc(-c2ccc(F)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20150038438A1,COC=C(C(=O)OC)C(=O)OC.COc1ccc(CN=C2CCCCc3cc(N(C)C)ccc32)c(OC)c1>>COC(=O)c1cc2c(n(Cc3ccc(OC)cc3OC)c1=O)-c1ccc(N(C)C)cc1CCC2,,c1ccc(Oc2ccccc2)cc1,,,,val
US20160244431A1,COC(=O)[C@@H]1N2C(=O)[C@@H](N)[C@@H]2SC1(C)C.ClCc1ccccn1.O=Cc1ccccn1>>COC(=O)[C@@H]1N2C(=O)[C@@H](N(Cc3ccccn3)Cc3ccccn3)[C@@H]2SC1(C)C,,CCO,,Cl,[BH4-].[Na+],val
US20040259912A1,COC(=O)c1cc(N)ccc1OC(c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1.COc1ccc(N=C=O)cc1OC>>COC(=O)c1cc(NC(=O)Nc2ccc(OC)c(OC)c2)ccc1OC(c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1,,C1CCOC1,,,,val
US20090264411A1,CC(C)(C)OC(=O)N1CC(=O)C1.C[N+](=O)[O-]>>CC(C)(C)OC(=O)N1CC(O)(C[N+](=O)[O-])C1,,CCO,,CCN(CC)CC,,val
US04415580,Cc1nccc2[nH]c(=O)c(C#N)cc12.O=S(=O)(O)O>>Cc1nccc2[nH]c(=O)c(C(N)=O)cc12,,CC(=O)O,,[NH4+].[OH-],,val
US20100216788A1,COc1cccc(-c2nc(C(C)(C)C)co2)c1>>CC(C)(C)c1coc(-c2cccc(O)c2)n1,,Br,,,,val
US04152455,CC(C)C(C(=O)Cl)c1ccc(Cl)cc1.OC(c1cccc(Oc2ccccc2)c1)C(F)(F)F>>CC(C)C(C(=O)OC(c1cccc(Oc2ccccc2)c1)C(F)(F)F)c1ccc(Cl)cc1,,Cc1ccccc1,,c1ccncc1,,val
US20150232445A1,CC1CCc2c(cccc2Oc2ccccc2)N1.O=C1CCC(=O)N1Br>>CC1CCc2c(ccc(Br)c2Oc2ccccc2)N1,,CC#N,,,,val
US06352993B1,CCOC(=O)CBr.c1ccc(CN2CCNCC2)cc1>>CCOC(=O)CN1CCN(Cc2ccccc2)CC1,,CCOCC,c1ccccc1,,,val
US20060194783A1,N[C@@H]1CC[C@@H](c2ccccc2)CN(CC2CC2)C1=O.O=C(Cl)N1CCC(N2Cc3ccccc3NC2=O)CC1>>O=C(N[C@@H]1CC[C@@H](c2ccccc2)CN(CC2CC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1,,ClCCCl,,CCN(C(C)C)C(C)C,,val
US05834506,CCOC(=O)C(Cc1ccc([N+](=O)[O-])cc1)C(=O)CCc1ccc([N+](=O)[O-])cc1>>O=C(CCc1ccc([N+](=O)[O-])cc1)CCc1ccc([N+](=O)[O-])cc1,,O,,C1CCOC1,Cl,val
US06936602B1,CCCOCCN(CC)c1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3C=O)cc1>>CCCOCCN(CC)c1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCN3C=O)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20080318944A1,CON(C)C(=O)C1CCCCN1C(=O)OC(C)(C)C.c1cnc2occc2c1>>CC(C)(C)OC(=O)N1CCCCC1C(=O)c1cc2cccnc2o1,,C1CCOC1,,[Cl-].[NH4+],,val
US04076709,O=C(O)c1cscc1Cl.O=S([O-])O>>O=C(O)c1cscc1S(=O)(=O)O,Cl[Cu],O,,[Na+].[OH-],,val
US20040215019A1,O=C(Nc1cccc2c1C(=O)NC2=O)c1ccc(Cl)s1.OCC1CCNCC1>>O=C(Nc1cccc2c1C(=O)N(CC1CCNCC1)C2=O)c1ccc(Cl)s1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090247559A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(O)C1CC(=O)N(C2CCN(Cc3ccccc3)CC2)C1>>CC(C)(C)OC(=O)N1CCC(N2CC(C(=O)O)CC2=O)CC1,[Pd],CO,,[H][H],,val
US05134111,CCOP(=O)(CC(=O)N1CCCCC1)OCC.CCc1cccc2c(C=O)cc(OC)c(OCOC)c12>>CCc1cccc2c(/C=C/C(=O)N3CCCCC3)cc(OC)c(OCOC)c12,,CN(C)C=O,,O,[H-].[Na+],val
US20110301161A1,CC1(C)OB(c2cnc(N)nc2)OC1(C)C.Cc1nc(-c2ccccc2-c2nc3cc(Br)ccc3n2C(C)(C)C)nn1C>>Cc1nc(-c2ccccc2-c2nc3cc(-c4cnc(N)nc4)ccc3n2C(C)(C)C)nn1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],,val
US20090099156A1,CC(C)(C)OC(=O)N1CCC[C@@H](CN2CCC(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1>>O=C(Nc1ccc(Cl)c(Cl)c1)C1CCN(C[C@@H]2CCCNC2)CC1,,C1COCCO1,CO,Cl,,val
US20150182507A1,COC(=O)CN(C)Cc1cn2ccccc2n1.O=C1CCC(=O)N1I>>COC(=O)CN(C)Cc1nc2ccccn2c1I,,CC#N,,O,,val
US04093631,CC1(C)C=C(c2cccc3ccccc23)c2ccc(OCC3CO3)cc2O1.CNC>>CN(C)CC(O)COc1ccc2c(c1)OC(C)(C)C=C2c1cccc2ccccc12,,CCO,,,,val
US20070128560A1,CCCCS.Nc1ncc(Br)s1>>CCCCSc1cnc(N)s1,,CCO,,Br,,val
US20090131413A1,CNCCO.O=[N+]([O-])c1ccc(F)c(F)c1>>CN(CCO)c1ccc([N+](=O)[O-])cc1F,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120213806A1,CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)OCOC(=O)[C@](C)(CO)C[C@H](N)Cc1ccc(-c2ccccc2)cc1.O=C(O)c1c[nH]nn1>>CC(C)[C@H](N)C(=O)OCOC(=O)[C@](C)(CO)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cnn[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050049254A1,CC(C)(C)OC(=O)N1CCNCC1.Cc1nc2cc(OCC3CO3)ccc2s1>>Cc1nc2cc(OCC(O)CN3CCN(C(=O)OC(C)(C)C)CC3)ccc2s1,,CCO,,,,val
US20130184463A1,COC(=O)c1ccc2c(cnn2Cc2cc(OCC(F)F)ccc2OCC(C)C)c1>>CC(C)COc1ccc(OCC(F)F)cc1Cn1ncc2cc(C(=O)O)ccc21,,C1CCOC1,O,CO,[Li+].[OH-],val
US20090312376A1,CI.CSc1ccc(CC(=O)O)cc1>>COC(=O)Cc1ccc(SC)cc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20090023800A1,C1CCNC1.Cc1c(Br)c2c(c(C)c1NC(=O)OC(C)(C)C)C(O)C(C)(C)O2>>Cc1c(Br)c2c(c(C)c1NC(=O)OC(C)(C)C)C(N1CCCC1)C(C)(C)O2,,CCCCCC,CCOC(C)=O,,,val
US20070299051A1,C1COCCN1.Cc1cc(C(=O)O)cc2c1Oc1c(Cl)cc(S(=O)(=O)Cl)cc1CS2(=O)=O>>Cc1cc(C(=O)O)cc2c1Oc1c(Cl)cc(S(=O)(=O)N3CCOCC3)cc1CS2(=O)=O,,CCOC(C)=O,,O,,val
US20100273753A1,BrCC#Cc1ccccc1.CC(C)Cn1c(=O)n(C)c(=O)c2c(Nc3ccccc3)[nH]nc21>>CC(C)Cn1c(=O)n(C)c(=O)c2c(Nc3ccccc3)n(CC#Cc3ccccc3)nc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05972965,CCOC(=O)COc1cccc2c1CCCC2NC(C)c1nc(-c2ccccc2)c(-c2ccccc2)o1.CI>>CCOC(=O)COc1cccc2c1CCCC2N(C)C(C)c1nc(-c2ccccc2)c(-c2ccccc2)o1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080194617A1,Cc1nn(C)c(-n2ccc3cc(Cl)ccc32)c1C=O>>Cc1nn(C)c(-n2ccc3cc(Cl)ccc32)c1CO,,C1CCOC1,CO,O,[BH4-].[Na+],val
US20160016928A1,c1ccc(C2CCc3cc(OC4CCC5(CC4)OCCO5)ccc3O2)cc1>>O=C1CCC(Oc2ccc3c(c2)CCC(c2ccccc2)O3)CC1,,C1CCOC1,CCOC(C)=O,Cl,,val
US04576749,CNC(C)C(=O)OCc1ccccc1.O=C(Cl)Cl.O=C(N[C@H]1CNC1=O)OCc1ccccc1>>C[C@@H](C(=O)OCc1ccccc1)N(C)C(=O)N1CC(NC(=O)OCc2ccccc2)C1=O,,Cc1ccccc1,ClCCl,CCN(CC)CC,CN(C)c1ccccn1,val
US20080027080A1,CC(C)(C)N[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3ccnc(C(C)(C)C)n3)C2=O)[C@H](N)C1.CCC(=O)OC(=O)CC.O=C(O)C(F)(F)F>>CCC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2ccnc(C(C)(C)C)n2)C1=O.O=C(O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20080096938A1,CC(C)(C)OC(=O)N1C(C)(C)OC[C@]1(C)c1ncc(-c2ccc(OCCCCCCc3ccccc3)c(C(F)(F)F)c2)s1>>C[C@](N)(CO)c1ncc(-c2ccc(OCCCCCCc3ccccc3)c(C(F)(F)F)c2)s1,,CC#N,O,,,val
US05516920,Cc1cc2c(c(C(C)(C)C)c1)OC(=O)C2O.O=S(Cl)Cl>>Cc1cc2c(c(C(C)(C)C)c1)OC(=O)C2Cl,CN(C)C=O,,,,,val
US20080132477A1,CC(=O)N1CCCCc2cc(ccc2O)C[C@@H]([C@H]2CN(Cc3cccc(C(C)C)c3)C(=O)O2)NC(=O)c2cc(Cl)nc1c2>>CC(C)c1cccc(CNC[C@@H](O)[C@@H]2Cc3ccc(O)c(c3)CCCCNc3cc(cc(Cl)n3)C(=O)N2)c1,,C1COCCO1,O,O=S(=O)(O)O,,val
US20150259298A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C1NC(=O)C2(CCCCC2)N1c1ccc(F)cc1>>O=C1NC(=S)N(c2ccc(F)cc2)C12CCCCC2,,Cc1ccccc1,,,,val
US04933453,COc1ccccc1N1CCNCC1.O=C1CSCN1CCCCBr>>COc1ccccc1N1CCN(CCCCN2CSCC2=O)CC1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US05925792,CC[C@H]1O[C@@H]1C(=O)O.NCc1ccccc1>>CC[C@@H](O)[C@@H](NCc1ccccc1)C(=O)O,,O,,[Na+].[OH-],,val
US20080045526A1,CCC1OC(=C2C(=O)Nc3ccccc32)c2cnc(Cl)c(Cl)c21.NCCN1CCOCC1>>CCC1OC(=C2C(=O)Nc3ccccc32)c2cnc(NCCN3CCOCC3)cc21,,C1COCCO1,,,,val
US20150018328A1,NNc1ccc(F)c(-c2nc(Nc3cc(F)cc(F)c3)nc(NC3CCC(F)(F)CC3)n2)n1>>Nc1ccc(F)c(-c2nc(Nc3cc(F)cc(F)c3)nc(NC3CCC(F)(F)CC3)n2)n1,[Ni],CO,,,,val
US04886814,COC(=O)COc1ccc(CC(C)NCC(O)c2csc(C(F)(F)F)n2)cc1.O=C(CBr)c1cccc(Cl)c1>>COC(=O)COc1ccc(CC(C)N2CC(c3csc(C(F)(F)F)n3)OC(O)(c3cccc(Cl)c3)C2)cc1,,CC(C)=O,,O=C([O-])O.[K+],,val
US20100160255A1,CCOC(=O)C1CCCN(C(=O)OCc2ccccc2)C1.COC(=O)SCl>>CCOC(=O)C1(SC(=O)OC)CCCN(C(=O)OCc2ccccc2)C1,,C1CCOC1,CCOC(C)=O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US04362728,N.O=C1c2ccccc2C(=O)N1CCSc1nccc(NC(=S)NCC(F)(F)F)n1>>NC(=NCC(F)(F)F)Nc1ccnc(SCCN2C(=O)c3ccccc3C2=O)n1,,CN(C)C=O,,,,val
US20080146607A1,CCCC1(C(O)c2ccc3c(ccn3C(=O)OC(C)(C)C)c2)CCCN1C(=O)OC(C)(C)C>>CCCC1(C(=O)c2ccc3c(ccn3C(=O)OC(C)(C)C)c2)CCCN1C(=O)OC(C)(C)C,,ClCCl,,,,val
US04546113,CC(=O)c1ccc(C#N)cc1.COC(=O)OC>>COC(=O)CC(=O)c1ccc(C#N)cc1,,C1COCCO1,,[H-].[Na+],,val
US20160158207A1,C1=COCC1.CC(=O)N1CCc2[nH]nc(N3CCCc4cc(-c5cnn(C)c5)ccc43)c2C1>>CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)ccc43)nn2C2CCCO2)C1,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20060058356A1,COC(=O)Cl.Cc1cc2c([N+](=O)[O-])c(Cl)ccc2[nH]1>>COC(=O)n1c(C)cc2c([N+](=O)[O-])c(Cl)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20040063940A1,COc1cccc(C2(O)CCCN(Cc3ccccc3)C2)c1.Oc1ccccc1>>COc1cccc(C2(c3ccc(O)cc3)CCCN(Cc3ccccc3)C2)c1,,[NH4+],[OH-],[Al+3].[Cl-].[Cl-].[Cl-],,val
US20040127574A1,CCOC(=O)C(Cc1ccc(Oc2ccccc2)cc1)C(O)c1ccc(F)cc1>>O=C(O)C(Cc1ccc(Oc2ccccc2)cc1)C(O)c1ccc(F)cc1,,CO,,Cl,[Na+].[OH-],val
US04466969,CCC#CCC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=C[C@H]1[C@H](OC(=O)c2ccccc2)C[C@@H]2OC(=O)C[C@@H]21>>CCC#CCC(=O)/C=C/[C@H]1[C@H](OC(=O)c2ccccc2)C[C@@H]2OC(=O)C[C@@H]21,,Cc1ccccc1,,,,val
US20150080364A1,C[C@H]1CN(Cc2ccc(N3CCOCC3)cc2F)CCN1C(=O)OC(C)(C)C>>C[C@H]1CN(Cc2ccc(N3CCOCC3)cc2F)CCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100222286A1,C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O[C@@H]6OC[C@H](O)[C@H](O)[C@H]6O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)[C@@](C)(CO)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@]43C)[C@@H]12,,O,,CO,Cl,val
US20030032626A1,CCCCCCC(O)c1ccc2cc(OC)ccc2c1>>CCCCCCC(=O)c1ccc2cc(OC)ccc2c1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US08901112B2,NCCNc1ccccn1.Nc1c(F)c(F)c2c3c1c(=O)c(C(=O)O)cn3C1(CCC1)CO2>>Nc1c(F)c(NCCNc2ccccn2)c2c3c1c(=O)c(C(=O)O)cn3C1(CCC1)CO2,,CS(C)=O,,CCN(CC)CC,,val
US04025635,O=C1c2ccccc2S(=O)(=O)c2cc(-c3nnn[nH]3)ccc21>>O=S1(=O)c2ccccc2Cc2ccc(-c3nnn[nH]3)cc21,[Zn],CC(=O)O,,Cl,,val
US20110165183A1,CN[C@H]1CN(C(=O)CC#N)CC[C@H]1C.ClC1=NC=CC2NC=CC12>>C[C@@H]1CCNC[C@@H]1N(C)c1nccc2[nH]ccc12,,C1COCCO1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20160046597A1,CC(C)(C)OC(=O)N1CC=C(c2c[nH]c3ccc([N+](=O)[O-])cc23)CC1.CI>>Cn1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)c2cc([N+](=O)[O-])ccc21,,C1CCOC1,CCCCCC,CCOC(C)=O,[H-].[Na+],val
US04810699,CCC1(CC(=O)OC)OCCc2c1[nH]c1c(OCC(F)(F)F)ccc(C)c21>>CCC1(CC(=O)O)OCCc2c1[nH]c1c(OCC(F)(F)F)ccc(C)c21,,CO,,O,,val
US20150094205A1,CSc1ncc(Cl)c(C(=O)O)n1.O=S(Cl)Cl>>CSc1ncc(Cl)c(C(=O)Cl)n1,CN(C)C=O,ClCCl,,,,val
US05451594,CCC(=O)Cl.Nc1cccc2oc(SCCC=C(F)F)nc12>>CCC(=O)Nc1cccc2oc(SCCC=C(F)F)nc12,,ClCCl,,CCN(CC)CC,,val
US20160176850A1,CC(C)(C)OC(=O)N1CC=C(c2nn(COCC[Si](C)(C)C)c3ncccc23)CC1>>CC(C)(C)OC(=O)N1CCC(c2nn(COCC[Si](C)(C)C)c3ncccc23)CC1,[Pd],CO,,,,val
US06313134B1,C=O.COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)NCC3>>COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3,,CO,,[BH4-].[Na+],,val
US20080287396A1,CCOP(=O)(OCC)C(N(C)Cc1ccccc1)P(=O)(OCC)OCC>>CCOP(=O)(OCC)C(NC)P(=O)(OCC)OCC,[Pd],CCO,,C1=CCCCC1,,val
US20060223799A1,CCOC(=O)C=O.Nc1ccc(Br)cc1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>CCOC(=O)c1cncn1-c1ccc(Br)cc1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20130225620A1,C1=COCCC1.FC(F)(F)c1cc(Br)c2cn[nH]c2c1>>FC(F)(F)c1cc(Br)c2cnn(C3CCCCO3)c2c1,,C1CCOC1,,,,val
US20120142700A1,CCOC(=O)c1csc(C2CCNCC2)n1.Cc1ccc(C)c(CC(=O)O)c1>>CCOC(=O)c1csc(C2CCN(C(=O)Cc3cc(C)ccc3C)CC2)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US04742052,COc1ccc(CC(Cc2ccc(OC)cc2)N2C(=O)C(C(C)=O)C2OC(C)=O)cc1>>COc1ccc(CC(Cc2ccc(OC)cc2)N2C(=O)C(C(C)O)C2OC(C)=O)cc1,,CC(C)O,O,[BH4-].[Na+],,val
US20090306048A1,CCOC(=O)C1CCNCC1.O=S(=O)(Cl)c1cccs1>>CCOC(=O)C1CCN(S(=O)(=O)c2cccs2)CC1,,c1ccncc1,,Cl,,val
US04483867,CC(OC(=O)[C@H]1CC[C@H](C#N)CC1)OC(=O)[C@H]1CC[C@H](C#N)CC1.ClC(Cl)Cl>>CC(OC(=O)[C@H]1CC[C@H](CN)CC1)OC(=O)[C@H]1CC[C@H](CN)CC1.Cl.Cl,O=[Pt],CCO,,,,val
US20030060474A1,CCOC(=O)N1CCN(C(=O)C(CCC(=O)O)NC(=O)c2cc(OC3(C(=O)OCC)CCC3)c3ccc(C)cc3n2)CC1>>CCOC(=O)N1CCN(C(=O)C(CCC(=O)O)NC(=O)c2cc(OC3(C(=O)O)CCC3)c3ccc(C)cc3n2)CC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20050215568A1,C=C1OCC1c1ccccc1.CC1(C)OO1>>c1ccc(C2COC23CO3)cc1,,ClCCl,,,,val
US05284840,CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC.[Li]C>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OC)C3)C(C)C(O)CC1(C)O)C(C)CC2OC,,C1CCOC1,,,,val
US20160159820A1,CCN1CCN(Cc2ccc(C(=O)O)cc2C)CC1.N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3[C@@H]12>>CCN1CCN(Cc2ccc(C(=O)N[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7c6CCC(=O)N7)cc5[C@@H]34)cc2C)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110288071A1,COc1cccc2c1C(=O)N(C)C2(C)C>>CN1C(=O)c2c(O)cccc2C1(C)C,,ClCCl,,BrB(Br)Br,,val
US20120010182A1,COc1ccc(CN(c2ccc(F)cn2)S(=O)(=O)c2cc(Cl)c(F)cc2F)c(OC)c1.Cn1nccc1-c1cc(-c2ccccc2)ccc1O>>Cn1nccc1-c1cc(-c2ccccc2)ccc1Oc1cc(F)c(S(=O)(=O)Nc2ccc(F)cn2)cc1Cl,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20160122336A1,C1CSCCN1.CC(C)(C)OC(=O)c1csc(C(=O)O)n1>>CC(C)(C)OC(=O)c1csc(C(=O)N2CCSCC2)n1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160106731A1,CCOC(=O)c1[nH]c2c(B3OC(C)(C)C(C)(C)O3)c(Cl)ccc2c1CCCOc1cc(C)c(Cl)c(C)c1.OO>>CCOC(=O)c1[nH]c2c(O)c(Cl)ccc2c1CCCOc1cc(C)c(Cl)c(C)c1,,C1CCOC1,,[Na+].[OH-],,val
US20100121048A1,CCOC(=O)c1ccn(Cc2ccccc2OC)c1-c1ccccc1>>COc1ccccc1Cn1ccc(C(=O)O)c1-c1ccccc1,,CCO,,[Li+].[OH-],,val
US20030229089A1,COc1nc(SC)nc(Cl)c1C(=O)Cl.NCc1ncccn1>>COc1nc(SC)nc(Cl)c1C(=O)NCc1ncccn1,,O,,CCN(CC)CC,ClCCl,val
US20140066369A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CS(=O)(=O)c1ccc(OCC2CCC(=O)CC2)c(F)c1>>CC(C)(C)[Si](C)(C)OC1=CCC(COc2ccc(S(C)(=O)=O)cc2F)CC1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20050143366A1,NC(=O)c1c(OCc2ccccc2)ccc([N+](=O)[O-])c1O>>NC(=O)c1c(OCc2ccccc2)ccc(N)c1O,,CO,,C,,val
US20120165331A1,COc1ccnc(N2CCC3(CCN(Cc4cn(S(=O)(=O)c5ccc(C)cc5)c5ccccc45)C3=O)C2)n1>>COc1ccnc(N2CCC3(CCN(Cc4c[nH]c5ccccc45)C3=O)C2)n1,,CO,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160016903A1,C=O.CN(C)C1(Cc2ccccc2)CCC2(CCNC2)CC1>>CN1CCC2(CCC(Cc3ccccc3)(N(C)C)CC2)C1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20060276533A1,COC(=O)c1sc(C2CCC(C)(C)CC2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C(CO[SiH](C(C)C)C(C)C)CO[Si](C(C)C)(C(C)C)C(C)C>>COC(=O)c1sc(C2CCC(C)(C)CC2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C(CO)CO,,C1CCOC1,CCOC(C)=O,c1ccncc1,O=C([O-])O.[Na+],val
US03987024,CC(C)(C)N=NC(C)(C#N)CCC(=O)Cl.CC(C)CC(C)(N=NC(C)(C)C)SCCO>>CC(C)CC(C)(N=NC(C)(C)C)SCCOC(=O)CCC(C)(C#N)N=NC(C)(C)C,,CCCCC,,O,c1ccncc1,val
US20140051679A1,CN1CCC(Oc2ccc(-c3n[nH]c4ccc(N)cc34)cc2)CC1.O=C(O)C(F)(F)F.O=C=Nc1ccccc1F>>CN1CCC(Oc2ccc(-c3n[nH]c4ccc(NC(=O)Nc5ccccc5F)cc34)cc2)CC1.O=C(O)C(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20160108039A1,CC1(C)OCC(CO[Si](C)(C)C(C)(C)C)N(Cc2ccccc2)C1=O>>CC1(C)OCC(CO)N(Cc2ccccc2)C1=O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100093814A1,C=CCBr.Cc1nc(N)sc1C>>Br.C=CCn1c(C)c(C)sc1=N,,CCOCC,Cc1ccccc1,,,val
US20070099990A1,Cc1c2c(c(C(C)(O)c3ccc(C(C)C)cc3)c(C)c1NC(=O)OC(C)(C)C)OCC2>>C=C(c1ccc(C(C)C)cc1)c1c(C)c(N)c(C)c2c1OCC2,,CCOC(C)=O,,Cl,O=C([O-])O.[Na+],val
US20090099155A1,CN(C)C(=O)CCCSc1c(Cl)ccc2c1CCN(C(=O)OC(C)(C)C)CC2.Cl>>CN(C)C(=O)CCCSc1c(Cl)ccc2c1CCNCC2.Cl,,ClCCl,,C1COCCO1,,val
US20090221575A1,COc1ccc2c(c1)CN(S(=O)(=O)CC(/C=C/c1ccco1)N(O)C=O)CC2>>COc1ccc2c(c1)CN(S(=O)(=O)CC(CCC1CCCO1)N(O)C=O)CC2,[Pd],CO,,[H][H],,val
US20100105664A1,Cc1[nH]c(-c2ccnc(Cl)c2)cc1C#N.OB(O)/C=C/c1ccc(F)cc1>>Cc1[nH]c(-c2ccnc(/C=C/c3ccc(F)cc3)c2)cc1C#N,,CCCO,,O=C([O-])[O-].[Na+].[Na+],,val
US07071175B1,CC(C)(C)OC(=O)Nc1ccc(CBr)cn1.CCC1C(=O)OC(C)(C)OC1=O>>CCC1(Cc2ccc(NC(=O)OC(C)(C)C)nc2)C(=O)OC(C)(C)OC1=O,,CS(C)=O,,CCN(CC)CC,O,val
US04059623,CN=C=O.CON=C(C)C(=NO)C(=O)N(C)C>>CNC(=O)ON=C(C(=O)N(C)C)C(C)=NOC,,ClCCl,,C1CN2CCN1CC2,,val
US20080188521A1,Cc1ccc2c(-c3ccccc3)cc(C#N)nc2c1.O=C1CCC(=O)N1Br>>N#Cc1cc(-c2ccccc2)c2ccc(CBr)cc2n1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20150126485A1,CN(C)C(=O)c1ccc(B(O)O)n1C(=O)OC(C)(C)C.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(Cl)c(I)c1>>CN(C)C(=O)c1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2Cl)[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US20100286129A1,BrBr.CCC(=O)c1ccc(NC(C)=O)c([N+](=O)[O-])c1>>CC(=O)Nc1ccc(C(=O)C(C)Br)cc1[N+](=O)[O-],,CC(=O)O,,O,,val
US05563169,CC(C)c1cccc(C(C)C)c1N.O=C(O)CC1c2ccccc2Oc2ccccc21>>CC(C)c1cccc(C(C)C)c1NC(=O)CC1c2ccccc2Oc2ccccc21,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20140364414A1,N#Cc1ccc(-c2cnc(N3CCOCC3)c3nc(COc4ccc5ccccc5n4)cn23)cn1.OO>>NC(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(COc4ccc5ccccc5n4)cn23)cn1,,CCO,CS(C)=O,Cl,[Na+].[OH-],val
US20080146526A1,CC(C)C(=O)O[C@H](OC(=O)ON1C(=O)[C@@H](OC(=O)c2ccccc2)[C@H](OC(=O)c2ccccc2)C1=O)C(C)C.NCCCP(=O)(O)CC1CCCCC1>>CC(C)C(=O)O[C@H](OC(=O)NCCCP(=O)(O)CC1CCCCC1)C(C)C,,O,,C1CCOC1,,val
US20100144825A1,CC1(C)COC(c2ccc(Cl)cc2I)=N1.CON(C)C(=O)CCN(C)C(=O)OC(C)(C)C>>CN(CCC(=O)c1cc(Cl)ccc1C1=NC(C)(C)CO1)C(=O)OC(C)(C)C,,C1CCOC1,,[Li]CCCC,,val
US20150218172A1,CC(C)n1cc(C(=O)c2ccnc(N)c2)c2cnc(N)nc21.O=C(O)Cc1ccc(Cl)cc1>>CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cnc(N)nc21,,C1CCOC1,CCOC(C)=O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US20050277689A1,COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12.O=C(O)c1ccccc1>>COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12.O=C([O-])c1ccccc1,,COC(C)(C)C,,CC(C)=O,,val
US05403843,CC(C)(C)OC(=O)NCCC[C@H](N)C(=O)O.CCOP(=O)(C#N)OCC.Nc1nc(N)c2c(CCc3ccc(C(=O)O)cc3)c[nH]c2n1>>COC(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)c1ccc(CCc2c[nH]c3nc(N)nc(N)c23)cc1,,CCN(CC)CC,,CN(C)C=O,,val
US20090209524A1,CCCCNc1nc(N)nc(C)c1Cc1ccc(CO)cc1OC.O=S(Cl)Cl>>CCCCNc1nc(N)nc(C)c1Cc1ccc(CCl)cc1OC,,ClCCl,,O=C([O-])O.[Na+],,val
US07439242B2,CCOC(=O)c1cc(N)ccc1Oc1cncc(Cl)c1.O=C(Cl)c1ccc(Cl)cc1Cl>>CCOC(=O)c1cc(NC(=O)c2ccc(Cl)cc2Cl)ccc1Oc1cncc(Cl)c1,,ClCCl,,c1ccncc1,,val
US20130116232A1,C[Si](C)(C)OC1(C(F)(F)F)c2cc(OC3CCCCO3)ccc2OC(c2ccc(I)cc2)C1c1ccc(OC2CCCCO2)cc1>>Oc1ccc(C2C(c3ccc(I)cc3)Oc3ccc(O)cc3C2(O)C(F)(F)F)cc1,,CO,Cl,,,val
US20040162276A1,C[Si](C)(C)CCOCCl.O=C(O)c1n[nH]c2c1C=CC(c1ccccc1)(c1ccccc1)C2>>C[Si](C)(C)CCOCn1nc(C(=O)O)c2c1CC(c1ccccc1)(c1ccccc1)C=C2,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20100168039A1,CC(C)(CO)CO.CCOC(=O)CSCC(=O)c1ccc2c(c1)OCO2>>CCOC(=O)CSCC1(c2ccc3c(c2)OCO3)OCC(C)(C)CO1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05001149,C/C=C(\C)C(=O)O[C@H]1C[C@@H](OC(C)=O)[C@@]2(C(=O)OC)CO[C@@H]3[C@@H]2[C@]12CO[C@](O)(C(=O)OC)[C@H]2[C@](C)([C@]12O[C@@]1(C)[C@H]1C[C@@H]2O[C@@H]2OC=C[C@]12O)[C@@H]3O>>CCC(C)C(=O)O[C@H]1C[C@@H](OC(C)=O)[C@@]2(C(=O)OC)CO[C@@H]3[C@@H]2[C@]12CO[C@](O)(C(=O)OC)[C@H]2[C@](C)([C@]12O[C@@]1(C)[C@H]1CC2O[C@@H]2OCC[C@]12O)[C@@H]3O,[Pd],CCO,,,,val
US04839377,CC(=O)Cl.N#CCc1c[nH]c2ccc(N)cc12>>CC(=O)Nc1ccc2[nH]cc(CC#N)c2c1,,CC#N,,O,c1ccncc1,val
US20060094767A1,C=C(C)CN(C(=O)[O-])c1ccc(Cl)cc1.O=C(OO)c1cccc(Cl)c1>>CC1(COC(=O)Nc2ccc(Cl)cc2)CO1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US04762848,CC(Br)C(=O)O.CCOC(=O)c1csc(S)n1>>O=C(O)CCSc1nc(C(=O)O)cs1,,O,,Cl,[Na+].[OH-],val
US20140194431A1,CS(=O)(=O)Cl.OCC1(c2cccc3ccccc23)CCCC1>>CS(=O)(=O)OCC1(c2cccc3ccccc23)CCCC1,,CCCCCC,ClCCl,CCN(CC)CC,CCOC(C)=O,val
US05763439,CCn1ncc(Br)c(C#N)c1=O.NCc1ccncc1>>CCn1ncc(NCc2ccncc2)c(C#N)c1=O,,CCO,,,,val
US20150307463A1,COc1ccccc1O.NC(=O)c1cc(-c2ccc(CBr)cc2)no1>>COc1ccccc1OCc1ccc(-c2cc(C(N)=O)on2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040198793A1,COC(=O)Cn1c(C(=O)NC(N)=S)cc2cc(OC)ccc21.COc1cc(C(=O)C(Br)CCC2CCCCC2)c(OC)cc1C>>COC(=O)Cn1c(C(=O)Nc2nc(-c3cc(OC)c(C)cc3OC)c(CCC3CCCCC3)s2)cc2cc(OC)ccc21,,CCO,,CCN(CC)CC,CN(C)C=O,val
US20100137281A1,CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1.COc1ccc(C(=O)CBr)c(OC)c1>>CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3OC)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US04141901,Cc1nnc(CNC(=O)CN2C(=O)c3ccccc3C2=O)n1-c1ccc(Cl)cc1C(=O)c1ccccc1.O>>Cc1nnc(CNC(=O)CN)n1-c1ccc(Cl)cc1C(=O)c1ccccc1.O,,CCO,,NN,,val
US20150087639A1,O=[N+]([O-])c1cnc(-c2ccc(N3CCOCC3)cc2)s1>>Nc1cnc(-c2ccc(N3CCOCC3)cc2)s1,[Pd],ClCCl,,,,val
US20040220403A1,CCOc1cccc(OCC)c1C(=O)OC.O=[N+]([O-])O>>CCOc1ccc([N+](=O)[O-])c(OCC)c1C(=O)OC,,ClCCl,,O,O=S(=O)(O)O,val
US05011849,COC(=O)c1cccc(I)c1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COC(=S)c1cccc(I)c1,,Cc1ccccc1C,,,,val
US20160039838A1,C#Cc1cccc(Nc2ncnc3cc(OCC)c(NC(=O)/C=C/CBr)cc23)c1.C1CO[C@H]2CNC[C@H]2O1>>C#Cc1cccc(Nc2ncnc3cc(OCC)c(NC(=O)/C=C/CN4C[C@H]5OCCO[C@H]5C4)cc23)c1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,O,val
US06365736B1,CC1Oc2ccc(CCN(Cc3cccc(Cl)c3)C(=O)OC(C)(C)C)cc2NC1=S.N>>CC1Oc2ccc(CCN(Cc3cccc(Cl)c3)C(=O)OC(C)(C)C)cc2N=C1N,,CO,,,,val
US04343803,CCOC(=O)CC(=O)CCl.N=C(N)C(Cl)(Cl)Cl>>Oc1cc(CCl)nc(C(Cl)(Cl)Cl)n1,,O,,O=C([O-])[O-].[K+].[K+],,val
US06255333B1,C#CCOC.N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1I>>COCC#Cc1c(C#N)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCN(CC)CC,,CN(C)C=O,,val
US20070078263A1,CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccc(Cc2ccc(-c3ccncc3)cc2)cc1.Cl>>Cl.c1cc(-c2ccc(Cc3ccc(OC[C@H]4CCCN4)cc3)cc2)ccn1,,C1COCCO1,,CCOCC,,val
US20100075964A1,CC(C)(O)c1cn(-c2ccc(Br)cc2)c(-c2ccccc2Cl)n1.COC(=O)c1cccc(B(O)O)c1>>COC(=O)c1cccc(-c2ccc(-n3cc(C(C)(C)O)nc3-c3ccccc3Cl)cc2)c1,,CCOC(C)=O,O,COCCOC,O=C([O-])[O-].[K+].[K+],val
US05266593,FC(F)(F)c1cccc(CBr)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>FC(F)(F)c1cccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1.[Br-],,Cc1ccccc1,,,,val
US20150126490A1,CC(=O)Cl.COC(=O)c1ccc(-c2nc(C3CCCNC3)cnc2N)cc1F>>COC(=O)c1ccc(-c2nc(C3CCCN(C(C)=O)C3)cnc2N)cc1F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20030158198A1,Cc1cc2c(N)cccc2c(C)n1.O=C=NCc1ccc(C(F)(F)F)c(F)c1>>Cc1cc2c(NC(=O)NCc3ccc(C(F)(F)F)c(F)c3)cccc2c(C)n1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US20120149662A1,CC(C)(C)C(=O)OCn1ccc2c(-c3cnn(C4CCCC4C#N)c3)cnnc21>>N#CC1CCCC1n1cc(-c2cnnc3[nH]ccc23)cn1,,CO,,[Na+].[OH-],,val
US20040259912A1,BrC(c1ccccc1)c1ccccc1.CC(C)(C)NC(=O)c1cc([N+](=O)[O-])ccc1O>>CC(C)(C)NC(=O)c1cc([N+](=O)[O-])ccc1OC(c1ccccc1)c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20140005175A1,COCCOCc1ccc([N+](=O)[O-])cc1>>COCCOCc1ccc(N)cc1,[Pt],CO,,,,val
US20070244132A1,CC(C)(C)OC(=O)NCCn1ccc2ncnc(Cl)c21.Cc1cc(N)ccc1Oc1cccc(C(F)(F)F)c1>>Cc1cc(Nc2ncnc3ccn(CCNC(=O)OC(C)(C)C)c23)ccc1Oc1cccc(C(F)(F)F)c1,,CCOC(C)=O,,CC(C)O,,val
US06627651B1,CN1CCCCC1.Cc1ccc(-c2ccc3c(c2)CN(C(=O)Cc2ccc(CBr)cc2)CC3)cc1>>Cc1ccc(-c2ccc3c(c2)CN(C(=O)Cc2ccc(C[N+]4(C)CCCCC4)cc2)CC3)cc1.[Br-],,CN(C)C=O,,,,val
US04006237,CC(=O)N(C1=C(C(=O)O)CCCC1)C(C)C>>CC(C)n1c2c(c(O)cc1=O)CCCC2,,C1COCCO1,,C[O-].[Na+],,val
US20160257678A1,CCc1cc2cc(C(=O)O)c3nc4ccccc4n3c2nc1N1CCCN(C)CC1>>CN1CCCN(c2ccc3cc(C(=O)O)c4nc5ccccc5n4c3n2)CC1,,C1COCCO1,O,[Na+].[OH-],,val
US20150119380A1,CS(=O)(=O)Cl.Cc1cn2cc(-c3cc4ccc(CCCO)cc4oc3=O)ccc2n1>>Cc1cn2cc(-c3cc4ccc(CCCOS(C)(=O)=O)cc4oc3=O)ccc2n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020123506A1,CCOC(=O)c1cn(Cc2c(F)cccc2F)c2cc(Br)c(CBr)cc2c1=O.CNCc1ccccc1>>CCOC(=O)c1cn(Cc2c(F)cccc2F)c2cc(Br)c(CN(C)Cc3ccccc3)cc2c1=O,,CCN(C(C)C)C(C)C,CN(C)C=O,CCOC(C)=O,O,val
US20160222005A1,Cc1cc(Br)cc([N+](=O)[O-])c1NC(=O)C(F)(F)F>>Cc1cc(Br)cc([N+](=O)[O-])c1N,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US20130289027A1,CNCC(=O)OC.Cc1ccc(C(=O)c2ccccc2C(=O)O)c(C)c1>>COC(=O)CN(C)C(=O)c1ccccc1C(=O)c1ccc(C)cc1C,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US20070179148A1,NCC(Cc1ccccc1)C(=O)N1CCN(c2ccc(Cl)c(Cl)c2)CC1.O=C(Cl)c1ccc(Cl)cc1>>O=C(NCC(Cc1ccccc1)C(=O)N1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccc(Cl)cc1,,C1CCOC1,,,,val
US20120270865A2,CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2nc3ccc(OC)cc3n2C)C2CCCCC2)cc1>>COc1ccc2nc(C(Nc3ccc(C(=O)N(C)CCC(=O)O)cc3)C3CCCCC3)n(C)c2c1,,CCO,,C1CCOC1,[Na+].[OH-],val
US20100233116A1,Cc1nc(-n2cnn(CCO)c2=O)sc1C(=O)NCc1cccnc1.Fc1ccc(CBr)cc1>>Cc1nc(-n2cnn(CCOCc3ccc(F)cc3)c2=O)sc1C(=O)NCc1cccnc1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20040082607A1,CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2ccccc2)c2cc(C=O)ccc2c1=O.CCOC(=O)CP(=O)(OCC)OCC>>CCOC(=O)/C=C/c1ccc2c(=O)n(CC(C)C)c(CNC(=O)OC(C)(C)C)c(-c3ccccc3)c2c1,,CN(C)C=O,,O,[H-].[Na+],val
US20160108056A1,CC(C)(c1cccc(CO)c1)c1cc(Br)cc([N+](=O)[O-])c1.CS(=O)(=O)Cl>>CC(C)(c1cccc(COS(C)(=O)=O)c1)c1cc(Br)cc([N+](=O)[O-])c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130040928A1,C1CNCCN1.CSc1nccnn1>>c1cnc(N2CCNCC2)nn1,,CCCCO,,CCN(CC)CC,CCOC(C)=O,val
US20160221945A1,COc1cnc(-c2cnc(C(F)(F)F)nc2)cc1CNC(=O)[C@@H]1C[C@@H](F)CN1.O=S(=O)(Cl)c1ccc(F)cc1>>COc1cnc(-c2cnc(C(F)(F)F)nc2)cc1CNC(=O)[C@@H]1C[C@@H](F)CN1S(=O)(=O)c1ccc(F)cc1,,ClCCl,O,,,val
US20090264402A1,CC(C)(C)OC(=O)N1CCN(C(=O)Oc2ccc(C=O)c(F)c2)CC1.Nc1ccc(F)cc1>>CC(C)(C)OC(=O)N1CCN(C(=O)Oc2ccc(/C=N/c3ccc(F)cc3)c(F)c2)CC1,,CCO,,CC(C)OC(C)C,,val
US20030018046A1,CC(C)(C)OC(=O)N(Cc1ccc(CNC2CCCc3cccnc32)cc1)Cc1ccccn1.O=C(c1ccccc1)c1ccc2nc(CCl)[nH]c2c1>>O=C(c1ccccc1)c1ccc2[nH]c(CN(Cc3ccc(CNCc4ccccn4)cc3)C3CCCc4cccnc43)nc2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20160251380A1,CC(C)(C)OC(=O)NCC1OB2OC(C)(C)C3=C2C(=C1Cl)C=COC3.Cl>>CC1(C)OB2OC(CN)C(Cl)=C3C=COCC1=C23.Cl,,C1COCCO1,,,,val
US20130274253A1,CN(C)C=O.O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2ccccc21>>Nn1c(CC(=O)N2CCc3ccccc32)nc(N2CCOCC2)cc1=O,,O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05420138,C#CCCCC.O=C(Cl)c1ccc(Br)cc1>>CCCCC#CC(=O)c1ccc(Br)cc1,,CCN(CC)CC,,,,val
US20160185777A1,CCOC(=O)c1n[nH]c2c1CN(C(=O)Nc1cccc(Cl)c1)CC2>>O=C(O)c1n[nH]c2c1CN(C(=O)Nc1cccc(Cl)c1)CC2,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20160102105A1,O=C(Cl)C(=O)Cl.O=C(O)c1ncc(Cl)cc1Cl>>O=C(Cl)c1ncc(Cl)cc1Cl,,ClCCl,,CN(C)C=O,,val
US20070010542A1,Cc1c(OCC2COC3(CCOCC3)OC2)ccnc1CSc1nc2ccccc2[nH]1.O=C(OO)c1cccc(Cl)c1>>Cc1c(OCC2COC3(CCOCC3)OC2)ccnc1CS(=O)c1nc2ccccc2[nH]1,,CO,Cc1ccccc1,O=C([O-])O.[Na+],,val
US20030017278A1,CCOC(=O)c1ccc(OCc2ccccc2)cc1>>O=C(O)c1ccc(OCc2ccccc2)cc1,,CO,,[K+].[OH-],,val
US20150175600A1,CC(C)(C)OC(=O)NC1CN(C(=O)OCc2ccccc2)CCC1O>>CC(C)(C)OC(=O)N[C@@H]1CNCC[C@@H]1O,[Pd],CO,,,,val
US20150087646A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccc(NN)cc1OC>>COC(=O)c1ccc(NNC(=O)OC(C)(C)C)cc1OC,,ClCCl,,,,val
US04612322,ClCBr.OC(c1ccc(Cl)cc1Cl)C(O)(Cn1cncn1)c1ccc(Cl)cc1>>Clc1ccc(C2(Cn3cncn3)OCOC2c2ccc(Cl)cc2Cl)cc1,,CN(C)C=O,,CCOCC,[H-].[Na+],val
US20040029902A1,CCCCCCOc1ccc(N)cc1.Fc1cnc(Cl)nc1Nc1ccc2c(c1)OCCO2>>CCCCCCOc1ccc(Nc2ncc(F)c(Nc3ccc4c(c3)OCCO4)n2)cc1,,OCCO,,CCN(C(C)C)C(C)C,,val
US20160159752A1,CC(C)(C)[Si](C)(C)OCCC[C@H]1CN(C(=O)OCc2ccccc2)CCN1S(=O)(=O)c1ccccc1>>O=C(OCc1ccccc1)N1CCN(S(=O)(=O)c2ccccc2)[C@@H](CCCO)C1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05726192,CN(C)C=O.ClCCCl.NNCC(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1.On1nnc2ccccc21>>Nc1cccc(CCC(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)O)n1,[Pd],CCO,,CCN(C(C)C)C(C)C,Cl,val
US20020055643A1,COc1cc2c(cc1O[Si](C)(C)C(C)(C)C)C(O)(c1cc(OC)c(OC)c(OC)c1)CCC2>>COc1cc2c(cc1O)C(c1cc(OC)c(OC)c(OC)c1)=CCC2,,O,,CC(=O)O,O=C([O-])O.[Na+],val
US20070099990A1,Cc1c(Cc2ccc(C(C)C)cc2)c2c(c(C)c1NC(=O)CC(C)(C)C)C(=O)C(C)(C)O2>>Cc1c(Cc2ccc(C(C)C)cc2)c2c(c(C)c1NC(=O)CC(C)(C)C)C(O)C(C)(C)O2,,C1CCOC1,CCCCCC,,,val
US20120059007A1,CCCCC(CC)CN.COc1cc(COC(=O)N2CCSC2=S)ccc1OC(C)=O>>CCCCC(CC)CNC(=O)OCc1ccc(OC(C)=O)c(OC)c1,,C1CCOC1,CCOCC,CCN(CC)CC,,val
US20140170207A1,CCCCCCCCCCCCOC(=O)C(C)N(C)C.CS(=O)(=O)O>>CCCCCCCCCCCCOC(=O)C(C)N(C)C.CS(=O)(=O)O,,CCOC(C)=O,,,,val
US20160137653A1,Cc1nccc(O[C@@H]2CC[C@@H](C(C)N)CC2)c1Cl.O=C(O)c1ccc(Cl)cc1>>Cc1nccc(O[C@@H]2CC[C@@H](C(C)NC(=O)c3ccc(Cl)cc3)CC2)c1Cl,,CN(C)C=O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20090048258A1,CCOC(=O)CCc1sc(N)cc1-c1ccccc1.CCOc1cc(C)c(C(=O)CCC(=O)O)cc1OCC>>CCOC(=O)CCc1sc(NC(=O)CCC(=O)c2ccc(OC)c(OC)c2)cc1-c1ccccc1,,CC#N,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US05545636,O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccc2c(c1)ccn2C1CCNCC1>>O=C(N1CCC(n2ccc3ccccc32)CC1)C(F)(F)F,,c1ccncc1,,,,val
US06265411B1,O=S(Cl)Cl.O=c1[nH]cnc2cc(OCCCN3CCOCC3)ccc12>>Clc1ncnc2cc(OCCCN3CCOCC3)ccc12,,CN(C)C=O,,,,val
US04518682,CCCCCCCCCCCCCCCCNC(=O)c1cc(Oc2ccccc2[N+](=O)[O-])c2ccccc2c1O>>CCCCCCCCCCCCCCCCNC(=O)c1cc(Oc2ccccc2N)c2ccccc2c1O.[OH-],[Fe],CC(C)O,,Cl,,val
US20140206681A1,COC(=O)[C@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)NCc1ccccc1>>CC(C)(C)[Si](OC[C@@H](CO)NCc1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,CO,[BH4-].[Li+],val
US20070149801A1,O=C(O)CCCO[N+](=O)[O-].O=S(Cl)Cl>>O=C(Cl)CCCO[N+](=O)[O-],CN(C)C=O,CCOCC,,,,val
US20090143361A1,CONC(=O)c1cccc(B(O)O)c1.COc1ccc2nc(C)c3c(C)nc(-c4cc(Cl)cc(Cl)c4)n3c2n1>>CONC(=O)c1cccc(-c2nc(C)c3c(C)nc4ccc(OC)nc4n23)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20080207900A1,C[C@@H](O)[C@H]1COC[C@@H](c2cc(F)c(F)c(F)c2)N1.O=C(Cl)OCc1ccccc1>>C[C@@H](O)[C@H]1COC[C@@H](c2cc(F)c(F)c(F)c2)N1C(=O)OCc1ccccc1,,CCOC(C)=O,O,C1CCOC1,O=C([O-])O.[Na+],val
US20070281918A1,CC1CN(C(=O)OC(C)(C)C)CCc2c(O)cc(=O)[nH]c21>>CC1CNCCc2c(O)cc(=O)[nH]c21,,CCOCC,,,,val
US20080153868A1,CCCCCC(=O)Cl.C[C@H]1NC(=O)O[C@H]1c1ccccc1>>CCCCCC(=O)N1C(=O)O[C@@H](c2ccccc2)[C@H]1C,,C1CCOC1,,[Li]CCCC,,val
US04351977,C1=C2CCC=C2CCCCCCCCC1>>C1CCCCCC2=C(CCCC1)CCC2,[Pd],Cc1ccccc1,,,,val
US04748087,C=CC(=O)O.CCCC[Sn](CCCC)(CCCC)O[Sn](CCCC)(CCCC)CCCC>>C=CC(=O)[O-].CCCC[Sn+](CCCC)CCCC,,c1ccccc1,,O,,val
US20040171881A1,CCCCc1nccc2ccc(C(=O)O)cc12.CCc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1>>CCCCc1nccc2ccc(C(=O)N[C@@H](Cc3cc(F)cc(F)c3)[C@H](O)CNCc3cccc(CC)c3)cc12,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110112067A1,Nc1ccc(Br)cc1CO.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C1Nc2ccc(Br)cc2CO1,,C1CCOC1,,,,val
US20120252801A1,CCN1CC(C)(C)OC(=O)C1CC(=O)OC(C)(C)C>>CCN1CC(C)(C)OC(=O)C1CC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080188528A1,COC(=O)c1cccn(CCC(c2ccccc2)c2ccccc2)c1=O>>O=C(O)c1cccn(CCC(c2ccccc2)c2ccccc2)c1=O,,C1CCOC1,CO,[Na+].[OH-],,val
US05532235,CCOC(=O)c1ccc(N)cc1.COc1cccc(OC)c1C(=O)Cl>>CCOC(=O)c1ccc(NC(=O)c2c(OC)cccc2OC)cc1,CN(C)c1ccncc1,ClCCl,O,CCN(CC)CC,,val
US20070088018A1,NCc1ccc(F)cc1.O=C(Cl)c1ccc(S(=O)(=O)Cl)cc1>>O=C(NCc1ccc(F)cc1)c1ccc(S(=O)(=O)Cl)cc1,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,N#N,val
US20140329794A1,CC(=O)N1CC(N)C1.O=C(NC[C@H](O)CN1CCc2ccccc2C1)c1cc(Cl)ncn1>>CC(=O)N1CC(Nc2cc(C(=O)NC[C@H](O)CN3CCc4ccccc4C3)ncn2)C1,,CC(C)O,,,,val
US20060025414A1,CN=C=S.Clc1cccc(-c2cc(C3CCCN3)no2)c1>>CNC(=S)N1CCCC1c1cc(-c2cccc(Cl)c2)on1,,ClCCl,,,,val
US20150210688A1,COC(=O)c1ccc(C)c(C(=O)CBr)c1.COCC(=N)N>>COCc1ncc(-c2cc(C(=O)OC)ccc2C)[nH]1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100064450A1,C1CCNC1.C=O.COc1cc(C=O)ccc1O>>COc1cc(C=O)cc(CN2CCCC2)c1O,,CCO,,,,val
US05095014,CN.O=C(Cl)N1CC(Oc2cc(C(F)(F)F)ccc2F)C1>>CNC(=O)N1CC(Oc2cc(C(F)(F)F)ccc2F)C1,,C1CCOC1,O,,,val
US20150232465A1,CC(=O)N1c2cc(N)c(-c3cnn(C4CC4)c3)cc2N(C(=O)OC(C)C)C[C@@H]1C.CNC(=O)Cl>>CNC(=O)Nc1cc2c(cc1-c1cnn(C3CC3)c1)N(C(=O)OC(C)C)C[C@H](C)N2C(C)=O,,ClCCl,,c1ccncc1,,val
US05712378,COc1ccc(C(OC[C@H]2O[C@@H](n3cc(C)c(=O)[nH]c3=O)C[C@@]23CO3)(c2ccccc2)c2ccc(OC)cc2)cc1>>COc1ccc(C(OC[C@H]2O[C@@H](n3cc(C)c(=O)[nH]c3=O)C[C@]2(C)O)(c2ccccc2)c2ccc(OC)cc2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130211075A1,CCOC(=O)c1cnn(-c2ccc(OC)cc2)c1C>>CCOC(=O)c1cnn(-c2ccc(O)cc2)c1C,,ClCCl,,O=C([O-])O.[Na+],,val
US20120225846A1,COC(=O)/C=C/c1cnc(-c2ccc(F)cc2)c(-c2ccc(F)cc2)n1>>O=C(O)/C=C/c1cnc(-c2ccc(F)cc2)c(-c2ccc(F)cc2)n1,,CO,O,[Na+].[OH-],,val
US20010034343A1,CCOCCn1c(N2CCCN(CCC3(c4ccccc4)CCNC3)CC2)nc2ccccc21.COc1ccc(C2C=NN=N2)cc1C(=O)O>>CCOCCn1c(N2CCCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(C5C=NN=N5)ccc4OC)C3)CC2)nc2ccccc21,,CCOC(C)=O,CO,Cl,,val
US04073795,CN(C)C=C(C=O)c1cc(OCc2ccccc2)ccc1[N+](=O)[O-].COC(=O)C[N+](=O)[O-]>>COC(=O)C(=CC(=CN(C)C)c1cc(OCc2ccccc2)ccc1[N+](=O)[O-])[N+](=O)[O-],,CC(=O)OC(C)=O,,,,val
US08673908B2,C1CCNC1.O=Cc1ccc(F)nc1>>O=Cc1ccc(N2CCCC2)nc1,,C1CCOC1,,,,val
US20160137659A1,Cc1c(-c2ccc(NC(=O)c3c(F)cccc3F)cc2)ccc2c1OC1(CCC1)CC2O>>Cc1c(-c2ccc(NC(=O)c3c(F)cccc3F)cc2)ccc2c1OC1(CCC1)CC2,,CCO,,[BH4-].[Na+],,val
US20150018367A1,C=C[Mg]Br.Cc1cc(F)c([N+](=O)[O-])cc1Br>>Cc1cc(F)c2[nH]ccc2c1Br,,C1CCOC1,,O,,val
US20140315888A1,CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc(Br)cc3nc2Cl)C1.NCCO>>CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc(Br)cc3nc2NCCO)C1,,CCO,,,,val
US06680338B2,COC(=O)C1(CSC(C)=O)CCOCC1.OCCCBr>>COC(=O)C1(CSCCCO)CCOCC1,,CO,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US05378690,CC(C)(C)C(=O)CBr.CCOC(=O)C(Cc1cccc2ccccc12)C(=O)OCC>>CCOC(=O)C(CC(=O)C(C)(C)C)(Cc1cccc2ccccc12)C(=O)OCC,,CN(C)C=O,,C[O-].[Na+],,val
US04064251,Cn1c(-c2ccccn2)cc2onc(-c3ccccc3)c2c1=O>>Cn1c(-c2ccccn2)cc(O)c(C(=N)c2ccccc2)c1=O,[Pd],CCO,,[H][H],,val
US20150080451A1,Nc1cccc(Cl)c1.O=S(=O)(Cl)/C=C/c1cccc(Cl)c1>>O=S(=O)(/C=C/c1cccc(Cl)c1)Nc1cccc(Cl)c1,,O,,C1CCOC1,O=C([O-])[O-].[Na+].[Na+],val
US20160137653A1,CCOC(=O)C(CC)C1CCC(=O)CC1>>CCOC(=O)C(CC)[C@@H]1CC[C@@H](O)CC1,,CCO,,[BH4-].[Na+],,val
US04528282,CCOC(=O)C(CCCC1(c2cccs2)OCCO1)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C>>C[C@H](NC(CCCC1(c2cccs2)OCCO1)C(=O)O)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C,,CCO,,,,val
US20160251306A1,CCOC(=O)c1cc(C)c(NC(=O)c2cc(-c3ccccc3)nc3ccccc23)c(C)c1>>Cc1cc(C(=O)O)cc(C)c1NC(=O)c1cc(-c2ccccc2)nc2ccccc12,,C1CCOC1,,Cl,[Na+].[OH-],val
US20070043072A1,N#CCCl.Nc1cc(Br)cnc1N>>ClCc1nc2cc(Br)cnc2[nH]1,,O,,C,,val
US20100035872A1,COC(=O)C(SC)c1ccccc1.NN>>CSC(C(=O)NN)c1ccccc1,,CCO,,O,,val
US20020147212A1,FC(F)(F)Oc1ccc(OCCCl)c(I)c1>>C=COc1ccc(OC(F)(F)F)cc1I,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20050026907A1,O=C(CCl)c1ccc2c(c1)OCCO2.O=C1CSC(=S)N1>>O=C1CSC(SCC(=O)c2ccc3c(c2)OCCO3)=N1,,CCO,O,[Na+].[OH-],,val
US20080021032A1,CC(C)(C)[Si](C)(C)OCCn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(Cl)c(Cl)c2)n1>>O=C(Nc1ccn(CCO)n1)[C@H](CC1CCCC1)c1ccc(Cl)c(Cl)c1,Cl,CCO,,,,val
US20020019526A1,C1CCNCC1.O=S(=O)(c1ccccc1)n1cc(Br)c2c(Cl)ncnc21>>O=S(=O)(c1ccccc1)n1cc(Br)c2c(N3CCCCC3)ncnc21,,CC(C)(C)O,,,,val
US20060205941A1,COC(=O)c1ccc(CBr)cc1.c1ccc2[nH]cnc2c1>>COC(=O)c1ccc(Cn2cnc3ccccc32)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150094297A1,CC(C)(C)OC(=O)N1CCC(c2nc(CO)cs2)CC1.COc1cc(O)c2cc(-c3cn4nc(OC)sc4n3)oc2c1>>COc1cc(OCc2csc(C3CCN(C(=O)OC(C)(C)C)CC3)n2)c2cc(-c3cn4nc(OC)sc4n3)oc2c1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20070281955A1,N#Cc1cccc(-c2nc3sccn3c2-c2ccnc(N[C@@H]3CCCNC3)n2)c1.O=S(=O)(Cl)c1ccc(Cl)cc1>>N#Cc1cccc(-c2nc3sccn3c2-c2ccnc(N[C@@H]3CCCN(S(=O)(=O)c4ccc(Cl)cc4)C3)n2)c1,,ClCCl,,CCN(CC)CC,Cl,val
US20150119412A1,CCOc1c(CN2CCC(n3ccc(C(=O)OC)c(C)c3=O)CC2)cc(C2CC2)c(-c2ccc(F)cc2)c1F>>CCOc1c(CN2CCC(n3ccc(C(=O)O)c(C)c3=O)CC2)cc(C2CC2)c(-c2ccc(F)cc2)c1F,,CCO,,[Na+].[OH-],,val
US20080255124A1,N#Cc1ccc(N(CCO)CC(F)(F)F)cc1C(F)(F)F.O=c1ccc(F)c[nH]1>>N#Cc1ccc(N(CCOc2ccc(F)cn2)CC(F)(F)F)cc1C(F)(F)F,,COCCOC,,,,val
US20150299224A1,CC(C)(C)[Si](C)(C)Cl.CO[C@@H]1[C@H](O)[C@@H](CO)C[C@H]1N1C(=O)c2ccccc2C1=O>>CO[C@@H]1[C@H](O)[C@@H](CO[Si](C)(C)C(C)(C)C)C[C@H]1N1C(=O)c2ccccc2C1=O,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20160168097A1,CCc1cc(C(F)(C(F)(F)F)C(F)(F)Cl)ccc1N.O=C1CCC(=O)N1Br>>CCc1cc(C(F)(C(F)(F)F)C(F)(F)Cl)cc(Br)c1N,,ClCCl,,[Na+].[OH-],,val
US20150087663A1,CCC(NC(=O)OC(C)(C)C)c1nc2cccc(C)c2c(=O)n1-c1ccccc1C>>CCC(N)c1nc2cccc(C)c2c(=O)n1-c1ccccc1C,,CCOC(C)=O,O,Cl,,val
US20080027070A1,Nc1cnc(N)nc1.O=C(Nc1ccc(Cl)c(C(=O)O)c1)c1cccc(C(F)(F)F)c1>>Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2Cl)cn1,,ClCCl,,CN1CCOCC1,,val
US04159981,CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(N)=O>>CC(C)[C@H](N)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(N)=O,[Pd],CO,,[H][H],,val
US20110257198A1,Cc1ccc(OCC2CC2)c(C(=O)N2CCCC[C@H]2Cc2nc3c(C)cccn3c2C)n1.Cl>>Cc1ccc(OCC2CC2)c(C(=O)N2CCCC[C@H]2Cc2nc3c(C)cccn3c2C)n1.Cl,,ClCCl,,CCOCC,,val
US20100298387A1,NS(=O)(=O)c1ccc(Cl)c(C(=O)O)c1.Nc1nnc(C2CCCCC2)s1>>NS(=O)(=O)c1ccc(Cl)c(C(=O)Nc2nnc(C3CCCCC3)s2)c1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US06506936B1,CCOC(=O)CCN(Cc1ccccc1)S(=O)(=O)c1ccc(OC)cc1.NO>>COc1ccc(S(=O)(=O)N(CCC(=O)NO)Cc2ccccc2)cc1,,CCOCC,,Cl,,val
US04692458,CC(=O)SCC(C)C(=O)O.CC(C)(C)OC(=O)[C@@H]1CCCN1>>CC(CS)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150210688A1,Cc1c[nH]c(CCC(N)=O)n1>>Cc1c[nH]c(CCC#N)n1,,Cc1ccccc1,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20020037885A1,C=CCC(Cc1ccccc1-c1noc2ccccc12)N=[N+]=[N-]>>C=CCC(N)Cc1ccccc1-c1noc2ccccc12,,C1CCOC1,CCOCC,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130116248A1,CC(C)(C#N)c1ccc([N+](=O)[O-])cn1>>CC(C)(C#N)c1ccc(N)cn1,[Ni],,,,,val
US04851418,CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)NC1CCN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C1>>NC(Cc1ccccc1)C(=O)NC1CCN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C1,,CCO,,Cl,,val
US20090069284A1,CC(C)(C)C(=C1CNC1)c1cc(F)cc(F)c1.N#Cc1cccc(C(Br)c2ccc(Cl)cc2)c1>>CC(C)(C)C(=C1CN(C(c2ccc(Cl)cc2)c2cccc(C#N)c2)C1)c1cc(F)cc(F)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20100311966A1,CCOC(=O)c1cnc(N2CC[C@H](N)[C@H](OC)C2)s1.O=C(O)c1nc(Cl)c(Cl)[nH]1>>CCOC(=O)c1cnc(N2CC[C@H](NC(=O)c3nc(Cl)c(Cl)[nH]3)[C@H](OC)C2)s1,CN(C)c1ccncc1,,,CCN=C=NCCCN(C)C,Cl,val
US04788206,COc1ccccc1C(=C/C=C/C(=O)O)c1ccccc1OC.O=[N+]([O-])c1ccc(O)cc1>>COc1ccccc1C(=C/C=C/C(=O)Oc1ccc([N+](=O)[O-])cc1)c1ccccc1OC,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20070249670A1,CCOC(=O)C(NC(=O)c1ccc(OC)cc1)C(=O)OCC>>CCOC(=O)c1nc(-c2ccc(OC)cc2)oc1OCC,,ClC(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US05338739,COc1ccc(C2CCC(=O)N2CCN2CCOCC2)cc1>>O=C1CCC(c2ccc(O)cc2)N1CCN1CCOCC1,,Br,,O=C([O-])O.[Na+],,val
US20140235620A1,CC(C)[C@H]1COC(=O)N1c1ccnc(Cl)n1.C[C@H](N)c1ccc(O)cc1>>CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(O)cc2)n1,,CCOC(C)=O,CS(C)=O,Cl,,val
US20070249589A1,CO.ClCc1cc(Cl)c(OCc2ccccc2)cn1>>COCc1cc(Cl)c(OCc2ccccc2)cn1,,CO,CS(C)=O,C[O-].[Na+],,val
US20020102224A1,CN(C)c1ccc(C=O)cc1.Cc1ccc(N)cc1O>>Cc1ccc(NCc2ccc(N(C)C)cc2)cc1O,,CO,,[BH3-]C#N.[Na+],,val
US04801593,O=C(O)C=Cc1ccc(Cl)cc1.Sc1ccccc1>>O=C(O)CC(Sc1ccccc1)c1ccc(Cl)cc1,,C1CCCCC1,,,,val
US03978067,COC(Cl)Cl.COc1cccc2c1CCN(C)C2>>COc1ccc(C=O)c2c1CCN(C)C2,Cl[Ti](Cl)(Cl)Cl,O,,ClCCl,[Na+].[OH-],val
US20100331326A1,CCC(=O)CN(C(=O)Nc1cnccc1C)c1ccc2ncsc2c1>>CCc1cn(-c2ccc3ncsc3c2)c(=O)n1-c1cnccc1C,,Cc1ccccc1,ClC(Cl)Cl,CO,,val
US20150057271A1,CC(C)(C)OC(=O)N1CC=C(c2cc(C(F)(F)F)ccc2N2CCOc3cc(S(=O)(=O)Nc4ncns4)ccc32)CC1>>O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1C1=CCNCC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20060263636A1,CC(N)CN.O=C(C(=O)c1ccc(F)cc1)c1ccc(F)cc1>>CC1CN=C(c2ccc(F)cc2)C(c2ccc(F)cc2)=N1,,CCO,,,,val
US20030207865A1,CN.Cc1cc([N+](=O)[O-])ccc1N=C1NC(CCl)CS1>>CNCC1CSC(=Nc2ccc([N+](=O)[O-])cc2C)N1,,CO,,,,val
US20090186870A1,COC(=O)c1cc(-n2cccn2)c(OC(C)C)cc1Cl.N>>CC(C)Oc1cc(Cl)c(C(N)=O)cc1-n1cccn1,,CO,,,,val
US20090291079A1,CC1(C)OB(c2ccc(N=C=O)cc2)OC1(C)C.CN>>CNC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)cc1,,C1CCOC1,,,,val
US04507498,CCCc1c(OCCOCCOc2c(C(C)=O)ccc(OCCCC(=O)OCC)c2CCC)ccc(C(C)=O)c1O>>CCCc1c(OCCOCCOc2c(C(C)=O)ccc(OCCCC(=O)O)c2CCC)ccc(C(C)=O)c1O,,CO,,[Na+].[OH-],,val
US20040009995A1,N#CCCCCBr.O=C1NC(=O)c2ccccc21>>N#CCCCCN1C(=O)c2ccccc2C1=O,,CN(C)C=O,,[K],,val
US20120077828A1,Nc1nccc2scc(-c3ccc4c(c3)CCN4C(=O)Cc3cc(F)ccc3F)c12.O=C1CCC(=O)N1I>>Nc1ncc(I)c2scc(-c3ccc4c(c3)CCN4C(=O)Cc3cc(F)ccc3F)c12,,CN(C)C=O,,O,,val
US05420164,CC(C)C1CCC(N=C=O)CC1.COc1cc(OC)c(N)c(OC)c1>>COc1cc(OC)c(NC(=O)NC2CCC(C(C)C)CC2)c(OC)c1,,ClC(Cl)Cl,,c1ccncc1,,val
US20060287522A1,O=C(Cl)Cc1ccc(Cl)cc1.O=C(NCc1cccnc1)c1ccc2n1Cc1ccccc1NC2>>O=C(NCc1cccnc1)c1ccc2n1Cc1ccccc1N(C(=O)Cc1ccc(Cl)cc1)C2,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20130116430A1,NCCN1CCCC1.O=[N+]([O-])c1ccc(Cl)nc1>>O=[N+]([O-])c1ccc(NCCN2CCCC2)nc1,,CCOC(C)=O,,CO,O,val
US05019575,CCOC=C(C(C)=O)C(C)=O.Nc1ccc(C2=NNC(=O)CC2)cc1>>CC(=O)C(=CNc1ccc(C2=NNC(=O)CC2)cc1)C(C)=O,,CCO,,,,val
US20130150343A1,CN1CCC[C@H](c2nnc3ccc(O[C@@H]4CC[C@H](N)c5ccccc54)cn23)C1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc([C@H]5CCCN(C)C5)n4c3)c3ccccc32)cc1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20060100201A1,CN1CCNCC1.O=[N+]([O-])c1ccc(Cl)cc1N1CCCCC1>>CN1CCN(c2ccc([N+](=O)[O-])c(N3CCCCC3)c2)CC1,,O,,,,val
US06011044,Cc1ccccc1N1CCc2c(Cl)nc3c(OC(F)(F)F)cccc3c21.NCCCCO>>Cc1ccccc1N1CCc2c(NCCCCO)nc3c(OC(F)(F)F)cccc3c21,,OCCOCCO,,,,val
US03960542,Cc1cc(C)c(C)c(CCl)c1.[O-][n+]1ccccc1S>>Cc1cc(C)c(CSc2cccc[n+]2[O-])c(C)c1,,CCO,,[Na],,val
US05030724,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)CON>>COC(=O)CONC(=O)OC(C)(C)C,,CC#N,,,,val
US20100029650A1,CC(C)c1noc(N2CCC(COS(C)(=O)=O)CC2)n1.CS(=O)(=O)c1ccc(-c2cnc(O)cn2)cc1>>CC(C)c1noc(N2CCC(COc3cnc(-c4ccc(S(C)(=O)=O)cc4)cn3)CC2)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080194549A1,CC(C)NC(=O)[C@@H]1CN(Cc2ccccc2)C[C@@H]1CO>>CC(C)NC[C@@H]1CN(Cc2ccccc2)C[C@@H]1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100240693A1,O=C1c2ccccc2C(=O)N1O.OCc1nc2cnc3cc(Br)ccc3c2s1>>O=C1c2ccccc2C(=O)N1OCc1nc2cnc3cc(Br)ccc3c2s1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04397786,CC(C)C[C@@H](C=O)NC(=O)OC(C)(C)C>>CC(C)C[C@@H](CO)NC(=O)OC(C)(C)C,,CO,,[BH4-].[Na+],,val
US20150274664A1,CC(C)(C)OC(=O)N1CCC([C@H]2C[C@@H]2CC=O)CC1.c1ccc(CNCc2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC([C@H]2C[C@@H]2CCN(Cc2ccccc2)Cc2ccccc2)CC1,,ClCCCl,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05393734,COC(=O)c1ccc(C(F)(F)F)[nH]c1=O.O=P(Br)(Br)Br>>COC(=O)c1ccc(C(F)(F)F)nc1Br,,O,,,,val
US20080306082A1,CC(C)(C)OC(=O)N1CCC(CCCN)CC1.O=C(NC1CC1)c1cccc2sc(-c3nc(Cl)ncc3F)cc12>>CC(C)(C)OC(=O)N1CCC(CCCNc2ncc(F)c(-c3cc4c(C(=O)NC5CC5)cccc4s3)n2)CC1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20160145247A1,CCOC[C@@H](NC(=O)OC(C)(C)C)c1cccc(Br)c1.COC(=O)Cc1ccccc1OCc1cccc(B2OC(C)(C)C(C)(C)O2)c1>>CCOC[C@@H](N)c1cccc(-c2cccc(COc3ccccc3CC(=O)O)c2)c1,,CN(C)C=O,,,,val
US20090088425A1,C=C(C(=O)c1ccc(=O)[nH]c1)c1ccc(Cl)cc1Cl>>CC(C(=O)c1ccc(=O)[nH]c1)c1ccc(Cl)cc1Cl,,CCOC(C)=O,,,,val
US20140179735A1,Cn1c(-c2ccccc2C(F)(F)F)c(C#CCNC(=O)OC(C)(C)C)c2cc(C(=O)O)c(O)cc21.O=C(O)C(F)(F)F>>Cn1c(-c2ccccc2C(F)(F)F)c(C(=O)CCN)c2cc(C(=O)O)c(O)cc21.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20130331374A1,CC(C)(C)[Si](C)(C)OCC1(CO[Si](C)(C)C(C)(C)C)Oc2ccc([N+](=O)[O-])cc2NC1=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)(C)[Si](C)(C)OCC1(CO[Si](C)(C)C(C)(C)C)Oc2ccc([N+](=O)[O-])cc2NC1=S,,Cc1ccccc1,,,,val
US20130072487A1,Br.CCOC(=O)CNC(=O)c1c(O)n(C2CCCN(C(=O)OCc3ccccc3)C2)c(=O)n(C2CCCCC2)c1=O>>Br.O=C(O)CNC(=O)c1c(O)n(C2CCCNC2)c(=O)n(C2CCCCC2)c1=O,,CC(=O)O,O,,,val
US20160046653A1,CC[SiH](CC)CC.c1ccc(-c2cccs2)nc1>>CC[Si](CC)(CC)c1ccc(-c2ccccn2)s1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20090099213A1,CC(C)(C)OC(=O)N1CCC(C(N)c2ccc(Cl)cc2)CC1.Cl>>Cl.NC(c1ccc(Cl)cc1)C1CCNCC1,,CO,,,,val
US20110190341A1,COc1ccc(C(NC(=O)OC(C)(C)C)C2CCC(=O)CC2)cc1>>COc1ccc(C(NC(=O)OC(C)(C)C)C2CCC(O)CC2)cc1,CO,C1CCOC1,,[BH4-].[Na+],,val
US20150152112A1,COC(=O)Nc1ccc(-c2cnc(C3CCc4nc(-c5cc(Cl)ccc5NC(=O)OC(C)(C)C)cc(=O)n43)[nH]2)cc1>>COC(=O)Nc1ccc(-c2cnc(C3CCc4nc(-c5cc(Cl)ccc5N)cc(=O)n43)[nH]2)cc1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20070111988A1,COC(=O)c1ccc2c(c1)OC(c1ccc(OCCN3CCCCC3)cc1)c1c-2ccc2cc(OC)ccc12>>COc1ccc2c3c(ccc2c1)-c1ccc(CO)cc1OC3c1ccc(OCCN2CCCCC2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040019072A1,CC(=O)c1cc2c(cc1O)C(C)(C)CCC2(C)C.O=C[O-]>>CC1(C)CCC(C)(C)c2cc3c(cc21)OC(O)CC3=O,,Cl,,[Na],,val
US20040266774A1,Cc1c(C(F)(F)F)[nH]c2c(C(=O)O)cccc12.Nc1cccc(-n2cncn2)c1>>Cc1c(C(F)(F)F)[nH]c2c(C(=O)Nc3cccc(-n4cncn4)c3)cccc12,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US04489073,CCOC(=O)NN=C(COC(C)=O)c1cc2ccccc2o1>>O=C1NN=C(c2cc3ccccc3o2)CO1,,CCO,O,CC(=O)O,[Na],val
US20060178401A1,Cc1c(C)c(OCC(=O)N(C)C2CCN(CC(=O)c3ccccc3)CC2)c(C)c(C)c1N>>Cc1c(C)c(OCC(=O)N(C)C2CCN(CC(O)c3ccccc3)CC2)c(C)c(C)c1N,,CO,,[BH4-].[Na+],,val
US20070032478A1,O=[N+]([O-])c1ccc(NCCN2CCOCC2)cc1>>Nc1ccc(NCCN2CCOCC2)cc1,[Ni],CCO,,NN,O,val
US20080027117A1,CI.O=C(Cn1cnc(-c2ccc(OCc3ccccc3)cc2)n1)c1ccc(F)cc1F>>CC(C(=O)c1ccc(F)cc1F)n1cnc(-c2ccc(OCc3ccccc3)cc2)n1,,CN(C)C=O,,O,[H-].[Na+],val
US20100069346A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OCCC1CNCCN1C1CN(C(c2ccccc2)c2ccccc2)C1>>CC(C)(C)OC(=O)N1CCN(C2CN(C(c3ccccc3)c3ccccc3)C2)C(CCO)C1,,ClCCl,,CCN(CC)CC,,val
US20060293340A1,Cc1ccc(N)cc1Nc1nccc(-c2cnccn2)n1.O=C(O)c1cccc(OC(F)(F)C(F)F)c1>>Cc1ccc(NC(=O)c2cccc(OC(F)(F)C(F)F)c2)cc1Nc1nccc(-c2cnccn2)n1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20090029976A1,Br[Mg]c1ccccc1.COc1cc(O)c(C=O)cc1Cl>>COc1cc(O)c(C(O)c2ccccc2)cc1Cl,,C1CCOC1,,,,val
US20030232848A1,CI.COc1ccccc1Oc1c(N)n(C)[nH]c1=O>>COc1ccccc1Oc1c(OC)nn(C)c1N,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050131014A1,CCOC(=O)c1cnc2c(C(F)(F)F)cccc2c1-c1ccccc1.OCc1cnc2c(C(F)(F)F)cccc2c1-c1ccccc1>>Cc1ccc(Cc2cnc3c(C(F)(F)F)cccc3c2-c2ccccc2)cc1,,C1CCOC1,,[BH4-].[Li+],,val
US04499295,CCCCCCCCCCCCCCCCCC(=O)Cl.CCOC(=O)c1ccccc1O>>CCCCCCCCCCCCCCCCCC(=O)Oc1ccccc1C(=O)OCC,,C1CCOC1,,CCN(CC)CC,,val
US20100227889A1,COCCn1c(-c2ccc(C(C)C)cc2)nc2cc(C(O)c3cccnc3SC)cc(OC)c21>>COCCn1c(-c2ccc(C(C)C)cc2)nc2cc(Cc3cccnc3SC)cc(OC)c21,[Zn],O=CO,,,,val
US20100125082A1,COc1cccc(C2(c3ccnc(C(F)(F)F)c3)N=C(N)c3c(F)cc(Cl)cc32)c1>>NC1=NC(c2cccc(O)c2)(c2ccnc(C(F)(F)F)c2)c2cc(Cl)cc(F)c21,,ClCCl,,BrB(Br)Br,,val
US20090069323A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1cc(F)cc(C#N)c1>>COC(=O)c1cc(F)cc(CNC(=O)OC(C)(C)C)c1,[Pd],CCOC(C)=O,,[H][H],,val
US20080015256A1,CC(=O)OCC(=O)NC[C@@H]1CCCc2cc(S(=O)(=O)c3cccc(F)c3)ccc21>>O=C(CO)NC[C@@H]1CCCc2cc(S(=O)(=O)c3cccc(F)c3)ccc21,,CO,,[Na+].[OH-],,val
US20110282069A1,CCOC(=O)c1sc(-c2ccc(OCC(C)C)c(C#N)c2)nc1C.[OH-]>>Cc1nc(-c2ccc(OCC(C)C)c(C(N)=O)c2)sc1C(=O)O,,C1CCOC1,,Cl,,val
US20020111367A1,CN1CCN(c2ccc(NC(=O)C(C)(C)C)c(C(=O)c3ccccc3)c2)CC1>>CN1CCN(c2ccc(N)c(C(=O)c3ccccc3)c2)CC1,,Cl,,,,val
US20090170908A1,C=CCCCC1=CC(O)CCC1(C)C>>CC1(C)CCC=CC12CCCC(O)C2,,O,,O=CO,,val
US20110275586A1,O=C(NCC[C@H](OC(=O)c1ccccc1)C(=O)Oc1c(F)c(F)c(F)c(F)c1F)OCc1ccccc1.[NH4+].[OH-]>>O=[N+]([O-])c1ccccc1O,,O,,O=C(O)C(F)(F)F,,val
US04831050,CC1(C)Oc2ccc(C#N)cc2[C@@H](N2CC(=O)CC2=O)[C@@H]1O>>CC1(C)Oc2ccc(C#N)cc2[C@@H](N2CC(O)CC2=O)[C@@H]1O,,CS(C)=O,,O,[BH4-].[Na+],val
US20110076292A1,C=Cc1ccc2c(c1)OCCn1cc(-c3nc(C)nn3C(C)C)nc1-2>>CCc1ccc2c(c1)OCCn1cc(-c3nc(C)nn3C(C)C)nc1-2,,CCO,,,,val
US20020045615A1,C1CCNC1.COc1ccc(-c2ccccc2)c2sc(NC(=O)c3ccc(Cl)nc3)nc12>>COc1ccc(-c2ccccc2)c2sc(NC(=O)c3ccc(N4CCCC4)nc3)nc12,,C1COCCO1,,,,val
US20120101103A1,COc1ccnc(-c2ccc(Cl)cc2)n1>>O=c1ccnc(-c2ccc(Cl)cc2)[nH]1,,O,,Cl,,val
US05576343,Cc1ccc2cc(C#N)ccc2c1.O=C1CCC(=O)N1Br>>N#Cc1ccc2cc(CBr)ccc2c1,,ClC(Cl)(Cl)Cl,,ClC(Cl)Cl,,val
US20060148858A1,CCCC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1C(=O)OCC>>CCCC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CO,,C1CCOC1,CCCCCC,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US06518273B1,CN1C(=O)CNC(=O)[C@@H]1Cc1ccccc1>>CN1CCNC[C@@H]1Cc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20150150999A1,CC(C)Cc1ccc(C(C)C(=O)Oc2ccc(C(=O)OC3COC(c4ccccc4)OC3)cc2)cc1>>CC(C)Cc1ccc(C(C)C(=O)Oc2ccc(C(=O)OC(CO)CO)cc2)cc1,,CC(=O)O,,,,val
US20060128713A1,CCOC(=O)c1cc2cc(OC(F)(F)F)ccc2[nH]1.N#CCCl>>CCOC(=O)c1cc2cc(OC(F)(F)F)ccc2n1CC#N,,CN(C)C=O,,O,[H-].[Na+],val
US05608056,CS(=O)(=O)O[C@@H]1C[C@@H](/C=C\c2cccnc2)N(C(=O)OCc2ccccc2)C1>>C=CCOC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1CCc1cccnc1,[Pd],CO,,Cl,[H][H],val
US20130190330A1,N.O=C(O)C(c1ccccc1Cl)n1cc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1>>NC(=O)C(c1ccccc1Cl)n1cc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20090286766A1,CCOC(=O)Cl.COC[C@H](C)N>>CCOC(=O)N[C@@H](C)COC,,C1CCOC1,,CCN(CC)CC,,val
US20070191395A1,BrCc1ccccc1.CCC(=O)CC(=O)OC>>CCC(=O)C(Cc1ccccc1)C(=O)OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120046469A1,C=CC(=O)O.COc1cc(N)c(Cl)cc1C=O>>C=CC(=O)Nc1cc(OC)c(C=O)cc1Cl,,CCOC(C)=O,O,CCN(CC)CC,Cl,val
US06420375B1,CCOC(=O)CBr.O=Cc1ccccc1O>>CCOC(=O)c1cc2ccccc2o1,,CCO,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20110021537A1,BrCc1ccccc1.CC(C)(C)OC(=O)N1CCC(C(=O)O)C1>>CC(C)(C)OC(=O)N1CCC(C(=O)OCc2ccccc2)C1,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,,val
US20130017194A1,C#Cc1ncccc1CC(=O)OC.CC(C)(C)OC(=O)N1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(Cl)n3)cc2)CC1.CCN(CC)CC>>NC(=O)Cc1cccnc1CCc1nc(Nc2ccc(C3CCNCC3)cc2)ncc1C(F)(F)F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,CN(C)C=O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100076029A1,CC(=O)SC1CCN(C(=O)OC(C)(C)C)CC1.CCOC(=O)C(C)(C)Br>>CCOC(=O)C(C)(C)SC1CCN(C(=O)OC(C)(C)C)CC1,,CCO,,[K+].[OH-],,val
US20090202652A1,CCOP(=O)(OCC)OC(C(=O)c1ccccc1)c1cccc(O[Si](C)(C)C(C)(C)C)c1.O=C1OCCO1.c1ccncc1>>O=C(c1ccccc1)C(OCCO)c1cccc(OCCO)c1,,C1CCOC1,,Cl,[K+].[OH-],val
US20160221972A1,COC(=O)c1ccc2c(c1)O[C@H](C)CNC2.COc1ccc(N=C=O)cc1>>COC(=O)c1ccc2c(c1)O[C@H](C)CN(C(=O)Nc1ccc(OC)cc1)C2,,ClCCl,,CCN(CC)CC,,val
US20070191603A1,COc1ccc(Cl)cc1S(=O)(=O)N1CCOc2ccc(C(=O)Nc3ccc(C#N)cc3)cc21.NO>>COc1ccc(Cl)cc1S(=O)(=O)N1CCOc2ccc(C(=O)Nc3ccc(C(=N)NO)cc3)cc21,,CS(C)=O,O,CCN(CC)CC,Cl,val
US20110263571A1,CI.Cc1cnc(N2CCN(C(=O)c3ccc(N4C(=O)OC[C@H]4CO)cc3)CC2)c(C)c1>>COC[C@@H]1COC(=O)N1c1ccc(C(=O)N2CCN(c3ncc(C)cc3C)CC2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20150232454A1,COc1cc(-c2ccc(C#N)cc2)c(-c2ccc(F)cc2)nc1OC>>N#Cc1ccc(-c2cc(O)c(=O)[nH]c2-c2ccc(F)cc2)cc1,,ClCCl,,BrB(Br)Br,,val
US20140205537A1,CCOC(=O)Cc1cc(F)ccc1[N+](=O)[O-].CC[O-]>>CCOC(=O)Cc1cc(OCC)ccc1[N+](=O)[O-],,CN(C)C=O,,O,,val
US20140148431A1,CC(C)(C)OC(=O)N1CC[C@@H](C(=O)NNC(=O)[C@H]2CC[C@@H]3CN2C(=O)N3OS(=O)(=O)O)C1>>O=C(NNC(=O)[C@@H]1CCNC1)[C@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050209338A1,CC(=O)O.Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc3c(c2)COC(C)(C)O3)cc(NC(N)=O)c1>>CC(=O)O.Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1,,O,,,,val
US20080188528A1,COC(=O)[C@@H](N)CCCNC(=O)OCc1ccccc1.O=C(O)c1cccn(C(c2ccccc2)c2ccccc2)c1=O>>COC(=O)[C@H](CCCNC(=O)OCc1ccccc1)NC(=O)c1cccn(C(c2ccccc2)c2ccccc2)c1=O,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080085886A1,CC(C)(C)[Si](C)(C)Cl.CC(O)COCc1ccccc1>>CC(COCc1ccccc1)O[Si](C)(C)C(C)(C)C,CN(C)c1ccncc1,ClCCl,,c1c[nH]cn1,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccc(N4CCOCC4)cc3)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3ccc(N4CCOCC4)cc3)c2)=C(C)C1=O,,CO,O,O=C([O-])O.[Na+],,val
US20160052871A1,Cc1cc(OCOc2ccc([N+](=O)[O-])c(C)c2)ccc1[N+](=O)[O-]>>Cc1cc(OCOc2ccc(N)c(C)c2)ccc1N,[Ni],C1COCCO1,,NN,O,val
US20160229839A1,COC(=O)Nc1ccc(-c2c[nH]c(C3C(c4ccccc4)CCCN3C(=O)OC(C)(C)C)n2)c(Br)c1>>COC(=O)Nc1ccc(-c2c[nH]c(C3NCCCC3c3ccccc3)n2)c(Br)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110071143A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC(CO)c1ccc(F)cc1>>CC(C)(C)OC(=O)NC(CO)c1ccc(F)cc1,,C1CCOC1,,,,val
US20090069340A1,CCOc1ccccc1N1CCNCC1.Cn1c(CBr)c(Cl)c(=O)n1C1CCCCC1>>CCOc1ccccc1N1CCN(Cc2c(Cl)c(=O)n(C3CCCCC3)n2C)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110281862A1,O=C(Br)CBr.c1ccc2c(c1)[nH]c1ncccc12>>O=C(CBr)c1ccc2[nH]c3ncccc3c2c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccco2)c1C#N.NCc1ncc(C(F)(F)F)cc1Cl>>N#Cc1c(NCc2ncc(C(F)(F)F)cc2Cl)nc(N)nc1-c1ccco1,,COCCOC,,C1CCC2=NCCCN2CC1,Cl,val
US20090227812A1,Nc1ccccc1.OC(c1ccc(I)cc1)(c1ccc(I)cc1)c1ccc(I)cc1>>Nc1ccc(C(c2ccc(I)cc2)(c2ccc(I)cc2)c2ccc(I)cc2)cc1,,CCO,,,,val
US04895860,Cc1cc2cc(Br)ccc2s1.O=C1CCC(=O)N1Br>>BrCc1cc2cc(Br)ccc2s1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20070213371A1,Cc1cc(Br)ccc1I.O=C1c2ccccc2C(=O)N1CO>>Cc1cc(Br)c(CN2C(=O)c3ccccc3C2=O)cc1I,,O=C(O)C(F)(F)F,,O,O=S(=O)(O)O,val
US06627629B2,CCOC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1N[C@H](C)c1ccccc1>>C[C@@H](N[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1C(=O)O)c1ccccc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20150336986A1,COC(=O)CC(=O)OC.Cn1c(=O)c2c(-c3cccc(F)c3)[nH]c(C(O)c3nc(Cl)cs3)c2n(C)c1=O>>COC(=O)C(C(=O)OC)C(c1nc(Cl)cs1)c1[nH]c(-c2cccc(F)c2)c2c(=O)n(C)c(=O)n(C)c12,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20160009665A1,O=C(O)c1ccc(-c2ncn(-c3ccc(OC(F)(F)C(F)(F)F)cc3)n2)cc1.O=S(Cl)Cl>>O=C(Cl)c1ccc(-c2ncn(-c3ccc(OC(F)(F)C(F)(F)F)cc3)n2)cc1,,ClCCl,,,,val
US20100069383A1,CC(C)Oc1ccc(N(C)c2nc(CCl)nc3ccccc23)cc1.CNc1ccc(OC(C)C)cc1.ClCc1nc(Cl)c2ccccc2n1>>CC(C)Oc1ccc(N(C)c2nc(CN)nc3ccccc23)cc1,Cl,,,,,val
US20080085905A1,Brc1cnc(N2CCCC2)c(OCC2CCCC2)n1.CO.[C]=O>>COC(=O)c1cnc(N2CCCC2)c(OCC2CCCC2)n1,,CO,,CCN(CC)CC,CCOC(C)=O,val
US20050137241A1,O=C(CCCBr)NC1(n2ccnc2)CC1>>O=C1CCCN1C1(n2ccnc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040157836A1,COC(=O)c1c2c(cc(/C=C/C(=O)O)c1NS(=O)(=O)c1ccccc1)CCCC2>>O=C(O)/C=C/c1cc2c(c(C(=O)O)c1NS(=O)(=O)c1ccccc1)CCCC2,,C1COCCO1,O,[Li+].[OH-],,val
US08076310B2,CC(C)OP(=O)(CO[C@H]1COC(O)(n2cnc3c(NC(=O)c4ccccc4)ncnc32)[C@@H]1OC(=O)c1ccccc1)OC(C)C>>CC(C)OP(=O)(CO[C@H]1COC(O)(n2cnc3c(N)ncnc32)[C@@H]1O)OC(C)C,,CO,,N,,val
US20120202688A1,Cc1cc(C)c(OC(=O)Cl)c(C)c1.NC1CC1c1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1>>Cc1cc(C)c(OC(=O)NC2CC2c2ccc(-c3ncn(-c4ccc(OC(F)(F)F)cc4)n3)cc2)c(C)c1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US04278686,CC(=O)NCCSC1=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)N2C(=O)[C@@H](C(C)O)[C@H]2C1.CS(=O)(=O)Cl>>CC(=O)NCCSC1=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)N2C(=O)[C@@H]([C@H](C)OS(C)(=O)=O)[C@H]2C1,,ClCCl,,CCN(CC)CC,,val
US20070299051A1,CC(C)N.COC(=O)c1cc(C)c2c(c1)S(=O)(=O)Cc1cc(NC(=O)CCl)cc(Cl)c1O2>>COC(=O)c1cc(C)c2c(c1)S(=O)(=O)Cc1cc(NC(=O)CNC(C)C)cc(Cl)c1O2,,CN(C)C=O,,,,val
US06130339,CCCC[Sn](CCCC)(CCCC)c1scc2c1OCCO2.O=[N+]([O-])c1ccc(Br)cc1>>O=[N+]([O-])c1ccc(-c2scc3c2OCCO3)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20130053364A1,C1CCOC1.COC(=O)c1c(CS(=O)(=O)c2ccccc2)ccc(-c2ccoc2)c1OS(=O)(=O)C(F)(F)F>>CCc1c(-c2ccoc2)ccc(CS(=O)(=O)c2ccccc2)c1C(=O)OC,,O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20060264486A1,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.COc1ccc2c(c1)N(C(C)=O)CC2=O>>COC(=O)Cc1cn(C(C)=O)c2cc(OC)ccc12,,Cc1ccccc1,,,,val
US20040077605A1,O=C(O)c1ccc2nonc2c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Nc1ccc2nonc2c1,,C1CCOC1,ClCCl,CCN(CC)CC,O=C([O-])[O-].[Na+].[Na+],val
US20110195954A1,O=C(O)c1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)ncn1.OCC1Cc2ccccc2N1>>O=C(c1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)ncn1)N1c2ccccc2CC1CO,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20090076070A1,C[C@H](Oc1ccc(-c2nc(-c3cccc4c3ccn4CC(=O)N3CCN(C(=O)OC(C)(C)C)CC3)no2)cc1C(F)(F)F)C(F)(F)F.Cl>>C[C@H](Oc1ccc(-c2nc(-c3cccc4c3ccn4CC(=O)N3CCNCC3)no2)cc1C(F)(F)F)C(F)(F)F.Cl,,ClCCl,,C1COCCO1,,val
US20030212071A1,COC(=O)C(Nc1ccc(C#N)cc1)c1cc(OC)c(OCc2ccccc2)cc1[N+](=O)[O-]>>COc1cc(C(CO)Nc2ccc(C#N)cc2)c([N+](=O)[O-])cc1OCc1ccccc1,,COCCOC,,[BH4-].[Li+],,val
US20070208054A1,CCC(=O)Cc1ccc(Br)cc1>>CCC(O)Cc1ccc(Br)cc1,,CCOC(C)=O,CO,[BH4-].[Na+],,val
US04988828,NCCCOc1cccc(CO)c1.O=C(CSCc1ccco1)Oc1ccc([N+](=O)[O-])cc1>>NC(=O)CSCc1ccco1,,C1CCOC1,,,,val
US20150191478A1,CCOC(OCC)c1cc2cncc(-c3ccc(OC)cc3)c2o1>>COc1ccc(-c2cncc3cc(C=O)oc23)cc1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US06251919B1,CC(C)(C)C#Cc1ccc(NC(=O)OC(C)(C)C)cc1>>CC(C)(C)CCc1ccc(NC(=O)OC(C)(C)C)cc1,[Pd],C1CCOC1,CO,,,val
US05763450,N#CCCNc1cccc(I)c1.O=C(Cl)C1CC1>>N#CCCN(C(=O)C1CC1)c1cccc(I)c1,,CCN(CC)CC,ClCCl,,,val
US20080021032A1,COCCn1ccc([N+](=O)[O-])n1>>COCCn1ccc(N)n1,[Pd],CCOC(C)=O,,CO,[H][H],val
US20100286148A1,O=C(OCCl)c1ccccc1Cl.O=c1nc(-c2cc(C(F)(F)F)ccn2)[nH]o1>>O=C(OCn1c(-c2cc(C(F)(F)F)ccn2)noc1=O)c1ccccc1Cl,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20100035883A1,CCOC(=O)c1cccc2c1C(=O)C(c1ccc(C)cc1)C(c1ccc(CN(CC)CC)cc1)N2.NN>>CCN(CC)Cc1ccc(C2Nc3cccc4c(=O)[nH]nc(c34)C2c2ccc(C)cc2)cc1,,CO,,O,,val
US20140065136A1,OC(COc1c(Cl)nc(Cl)nc1N1CCOCC1)C1CC1>>Clc1nc2c(c(N3CCOCC3)n1)OCC(C1CC1)O2,,C1CCOC1,,[H-].[Na+],,val
US20160214997A1,CCOC(=O)Cc1cccnc1Cl.NN>>NNC(=O)Cc1cccnc1Cl,,CO,,O,,val
US20100168136A1,Cc1cc(C(N)=O)ncc1C(SCCC1(CCOCc2ccccc2)OCCO1)c1c(F)ccc(F)c1F>>Cc1cc(C(N)=O)ncc1C(SCCC(=O)CCOCc1ccccc1)c1c(F)ccc(F)c1F,,C1COCCO1,,Cl,O,val
US20100105744A1,CCO.CSCc1cccc2c(C(c3ccc(Cl)cc3Cl)C3C(=O)OC(C)(C)OC3=O)c[nH]c12>>CCOC(=O)CC(c1ccc(Cl)cc1Cl)c1c[nH]c2c(CSC)cccc12,[Cu],CCO,c1ccncc1,,,val
US20040127432A1,CC(C)C[AlH]CC(C)C.CC(C)[N-]C(C)C.CN(C)c1ccncc1.[Li+]>>CC(C)NC(C)C.[Li]CCCC,CN(C)c1ccncc1,C1CCOC1,ClCCl,,,val
US20030125370A1,CCN=C=NCCCN(C)C.Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)O.NCNCC(F)(F)F>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)NCCNCC(F)(F)F,,CN(C)C=O,,On1nnc2ccccc21,,val
US20090130117A1,COc1ccc(C(C)C)cc1-c1cc(C(=O)O)c(OCc2ccccc2)cc1OCc1ccccc1.NCCc1ccccc1>>COc1ccc(C(C)C)cc1-c1cc(C(=O)NCCc2ccccc2)c(OCc2ccccc2)cc1OCc1ccccc1,,CN(C)C=O,O,O=C(n1ccnc1)n1ccnc1,,val
US20040254175A1,O=[N+]([O-])c1ccc(NS(=O)(=O)CCCCl)cc1>>O=[N+]([O-])c1ccc(N2CCCS2(=O)=O)cc1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030069299A1,O=[N+]([O-])c1ccc(CN2CCN(Cc3ccccc3)CC2)cc1>>Nc1ccc(CN2CCN(Cc3ccccc3)CC2)cc1,[Pd],,,,,val
US20010051631A1,CCOC(=O)c1cccc2ncc(C(=O)C(Cl)(Cl)Cl)n12.N>>O=c1[nH]c(=O)c2cnc3cccc1n32,,CC#N,,,,val
US04976874,Br.CCCCCCCCN(C)C>>Br.CCCCCCCCN(C)C,,O,,,,val
US20160052898A1,COc1ccc(N)cc1NC(=O)CN1CCOCC1.O=C(O)c1ccc(-c2cccc(Cl)c2)cc1>>COc1ccc(NC(=O)c2ccc(-c3cccc(Cl)c3)cc2)cc1NC(=O)CN1CCOCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20030105139A1,COc1cc2c(cc1C(F)(F)F)NCC2.Nc1ccc2c(ccn2Cc2cccnc2)c1.O=C(n1ccnc1)n1ccnc1>>COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc3c(ccn3Cc3cccnc3)c1)CC2,,CN(C)C=O,ClCCl,O,,val
US06387911B1,CCSc1ccccc1C(=O)OC>>CCSc1ccccc1CO,,C1CCOC1,CCOC(C)=O,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20130345120A1,C=CCOC(=O)N1CCC(C(=O)Nc2ncccn2)N1C(=O)[C@H](CC1CCCC1)CN(C=O)OC1CCCCO1>>O=CN(C[C@@H](CC1CCCC1)C(=O)N1NCC[C@H]1C(=O)Nc1ncccn1)OC1CCCCO1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,,C1COCCN1,,val
US09090628B2,CN1CCC(NN)CC1.Cc1cc2c(cc1C(=O)/C=C/N(C)C)OCCn1cc(-c3ncnn3C(C)C)nc1-2>>Cc1cc2c(cc1-c1ccnn1C1CCN(C)CC1)OCCn1cc(-c3ncnn3C(C)C)nc1-2,,CC(=O)O,,Cl,,val
US20100010053A1,CCOC(=O)CCc1c[nH]c2c(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)ccc(F)c12.CI>>CCOC(=O)CCc1cn(C)c2c(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)ccc(F)c12,,CS(C)=O,,[K+].[OH-],,val
US20100004245A1,Clc1ccc(Cl)nn1.OC1CNC1>>OC1CN(c2ccc(Cl)nn2)C1,,O,,Cl,[Na+].[OH-],val
US20130296301A1,C=CCN(C(=O)OC(C)(C)C)C1=N[C@H]2[C@H](O[C@H](C(C)=O)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)S1.C[Si](C)(C)C(F)(F)F>>C=CCN(C(=O)OC(C)(C)C)C1=N[C@H]2[C@H](O[C@H](C(C)(O)C(F)(F)F)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)S1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110224195A1,CN(C)/C=C1/CN(C(=O)OC(C)(C)C)CC1=O.NN>>CC(C)(C)OC(=O)N1Cc2cn[nH]c2C1,,CCO,,,,val
US20140094475A1,COc1cc(/C=C/C(=O)O)ccc1O.Nc1nc(NC2CC2)c2ncn([C@H]3C=C[C@@H](CO)C3)c2n1>>COc1cc(/C=C/C(=O)[O-])ccc1O.Nc1nc(NC2CC2)c2ncn([C@H]3C=C[C@@H](CO)C3)c2n1,,CO,,,,val
US20100190775A1,CI.O=C1NC(=O)c2cc(I)ccc21>>CN1C(=O)c2ccc(I)cc2C1=O,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US05182279,CCOC(=O)C(=O)Nc1sc2ccccc2c1NC(=O)C(=O)OCC>>O=c1[nH]c2sc3ccccc3c2[nH]c1=O,,Cl,,,,val
US20110212937A1,CCN(C)c1nc(Cl)nc2c1CCCC2c1ccccc1.COc1cc(N)ccc1-n1cnc(Cl)c1>>CCN(C)c1nc(Nc2ccc(-n3cnc(Cl)c3)c(OC)c2)nc2c1CCCC2c1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20160106842A1,CCCCCCCCC(CCCCCCCC)CC(=O)OCC>>CCCCCCCCC(CCCCCCCC)CC(=O)O,,CO,ClCCl,Cl,[Na+].[OH-],val
US04788195,CI.COc1ccc(Nc2nccc(-c3cccnc3)n2)cc1>>COc1ccc(N(C)c2nccc(-c3cccnc3)n2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100249151A1,COc1cc(OC)c2c(c1)C(=O)OC2O.Nc1ncccn1>>COc1cc(OC)c(C=Nc2ncccn2)c(C(=O)O)c1,,CCO,,CCCCCCC,,val
US04128650,CCOC(=O)CBr.Oc1c2c3c(ccnc3c3ccccc13)CCC2>>CCOC(=O)COc1c2c3c(ccnc3c3ccccc13)CCC2,,CN(C)C=O,,[H-].[Na+],,val
US20130131018A1,CCOC(CNCc1cccc(OC)c1OC)OCC.COc1cc(C=O)cc(OC)c1O.Cl>>COc1cc(Cc2cncc3c(OC)c(OC)ccc23)cc(OC)c1O.Cl,,CCO,,CO,,val
US20160002259A1,CCOC(OCC)OCC.Nc1cccc(Br)c1.[N-]=[N+]=[N-]>>Brc1cccc(-n2cnnn2)c1,,CC(=O)O,,O,,val
US20130343992A1,COC(OC)N(C)C.O=C(Cc1ccncc1)c1ccc(OCc2ccc3ncccc3n2)cc1>>CN(C)C=C(C(=O)c1ccc(OCc2ccc3ncccc3n2)cc1)c1ccncc1,,CCOC(C)=O,CO,,,val
US05994368,CC(=O)OC(C)=O.COc1cc(CO)ccc1N>>COc1cc(CO)ccc1NC(C)=O,,CO,,,,val
US20140005168A1,CC(C)(C)OC(=O)N1CCN(c2cccc(-n3ncc4cnc(-c5cn[nH]c5)cc43)n2)CC(O)C1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)CC(O)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US03979381,CCCNN.O=C1C(=Cc2ccccc2)CS(=O)CC1=Cc1ccccc1>>CCCN1N=C2C(=Cc3ccccc3)CS(=O)CC2C1c1ccccc1,,CO,,,,val
US20140275007A1,CC(C)(C)OC(=O)N[C@@H]1C(=O)N(O)C1(C)C>>CC1(C)[C@H](N)C(=O)N1O,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20090264445A1,CC(C)Oc1ccccc1O.CCOC(=O)C=C(C)Cl>>CCOC(=O)/C=C(\C)Oc1ccccc1OC(C)C,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20060217372A1,NC(=O)c1ccc(Oc2ccc(C=O)cc2)cn1.NCCc1ccc(F)cc1>>NC(=O)c1ccc(Oc2ccc(CNCCc3ccc(F)cc3)cc2)cn1,,CO,,[BH4-].[Na+],,val
US20100273764A1,O=[N+]([O-])c1cccc2c1cnn2C1CCCCO1>>Nc1cccc2c1cnn2C1CCCCO1,[Pd],CCOC(C)=O,,,,val
US20120190678A1,CC(=O)Oc1ccc(N2CCN(C)CC2)cc1Br>>CN1CCN(c2ccc(O)c(Br)c2)CC1,,CO,,CC(=O)O,[Na+].[OH-],val
US20090156572A1,CCOC(=O)C1CCN(C(=O)C2CC2)CC1>>O=C(O)C1CCN(C(=O)C2CC2)CC1,,CCO,,[Na+].[OH-],,val
US20050032873A1,CCOC(CBr)OCC.Fc1ccc(S)cc1>>CCOC(CSc1ccc(F)cc1)OCC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160244434A1,BrCCc1ccccc1.O=[N+]([O-])c1ccc(-c2ncc[nH]2)cc1>>O=[N+]([O-])c1ccc(-c2nccn2CCc2ccccc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100305067A1,CC(C)(C)OC(=O)N1CCC(n2ccc(B3OC(C)(C)C(C)(C)O3)cc2=O)C1.CCNC(=O)Nc1nc2cc(Br)c(F)cc2s1>>CCNC(=O)Nc1nc2cc(-c3ccn(C4CCN(C(=O)OC(C)(C)C)C4)c(=O)c3)c(F)cc2s1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20160075713A1,CCOC(=O)C(F)(F)c1ccc(C(F)F)cc1>>OCC(F)(F)c1ccc(C(F)F)cc1,,CCO,,[BH4-].[Na+],,val
US04665070,CCOc1nc2cc([N+](=O)[O-])ccc2c(=O)o1>>CCOc1nc2cc(N)ccc2c(=O)o1,[Pd],c1ccccc1,,C1=CCCCC1,,val
US04847386,COC(=O)C1SCC(=O)C1C(=O)OC.Cl.NO>>COC(=O)c1scc(N)c1C(=O)OC.Cl,,CCC#N,,CCOCC,,val
US06127379,COC(=O)c1cccc2c1SCC=C2>>COC(=O)c1cccc2c1SCCC2,,CCO,,,,val
US20150025068A1,CC(=O)c1cccc(S(=O)(=O)Nc2ccc(C(=O)O)c(O)c2)c1>>CC(O)c1cccc(S(=O)(=O)Nc2ccc(C(=O)O)c(O)c2)c1,,CO,,[BH4-].[Na+],,val
US20100063125A1,COc1cc(OC)c2[nH]ccc2c1C=C[N+](=O)[O-].C[N+](=O)[O-]>>COc1cc(OC)c2[nH]ccc2c1C(C[N+](=O)[O-])C[N+](=O)[O-],,C[N+](=O)[O-],,O=C([O-])O.[Na+],,val
US20040242554A1,CC(C)(C)OC(=O)N1CCN(c2nccnc2OCCOc2cccc(O)c2)CC1.COCCBr>>COCCOc1cccc(OCCOc2nccnc2N2CCN(C(=O)OC(C)(C)C)CC2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20080021028A1,COC(C)(C)OC.C[C@H](C(=O)O)[C@@H](O)C(=O)O>>C[C@H](C(=O)O)[C@H]1OC(C)(C)OC1=O,Cl[Cu]Cl,CC(C)=O,,,,val
US20090036492A1,COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.O=S(=O)(O)O>>COc1cc(O)c2c(c1C(=O)O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,,CC#N,,O=N[O-].[Na+],,val
US20090082434A1,Cc1ccc(S(=O)(=O)OCC2Cc3c(Br)cccc3O2)cc1.OB(O)c1ccccc1C(F)(F)F>>Cc1ccc(S(=O)(=O)OCC2Cc3c(cccc3-c3ccccc3C(F)(F)F)O2)cc1,Cc1ccccc1[P](c1ccccc1C)(c1ccccc1C)[Pd](Cl)(Cl)[P](c1ccccc1C)(c1ccccc1C)c1ccccc1C,,,O=C([O-])[O-].[K+].[K+],,val
US20160200695A1,COc1ccc2nc(NC(=O)c3ccc(Br)cc3)sc2c1.O=Cc1ccncc1>>COc1ccc2nc(NC(=O)c3ccc(C(O)c4ccncc4)cc3)sc2c1,,CO,ClCCl,,,val
US20040157890A1,BrC(Br)(Br)Br.CCOC(=O)/C=C/c1ccc(CO)cc1C>>CCOC(=O)/C=C/c1ccc(CBr)cc1C,,ClCCl,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050124616A1,CSc1nccc2c(-c3ccnc(NC4CCCC4)n3)c(-c3cccc(Cl)c3)nn12.NC1CCCC1>>Clc1cccc(-c2nn3c(NC4CCCC4)nccc3c2-c2ccnc(NC3CCCC3)n2)c1,,CCOC(C)=O,ClCCl,O=C(OO)c1cccc(Cl)c1,,val
US03971772,C=C(C)CO[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CCl.O=C(OO)c1cccc(Cl)c1>>CC1(CO[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O)C(=O)CCl)CO1,,ClCCl,,,,val
US06777432B1,C1CCOC1.COC(=O)CS.O=C(Nc1ccc(F)cc1)c1ccc(Cl)nc1>>CCOC(=O)CSc1ccc(C(=O)Nc2ccc(F)cc2)cn1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20140288123A1,CC(C)(C)OC(=O)c1ccc(C2=CCCC2)cc1>>CC(C)(C)OC(=O)c1ccc(C2CCCC2)cc1,[Pd],CO,,,,val
US20100331293A1,CCOC(=O)C(C)C(=O)Nc1cc(F)cc(F)c1>>CC(C(=O)O)C(=O)Nc1cc(F)cc(F)c1,,C1CCOC1,O,[Na+].[OH-],,val
US20070244095A1,Cc1cc2c(cc1C(F)(F)F)NCCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1.O=C1CCN(Cc2ccccc2)CC1>>Cc1cc2c(cc1C(F)(F)F)N(C1CCN(Cc3ccccc3)CC1)CCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1,,CC#N,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20090270433A1,COC(=O)N=C(SC)C(=Nc1ccc(C#N)c(CNC(=O)OC(C)(C)C)c1)c1cc2c(c(OC)c1)OCOC2.COC(=O)c1sccc1NN>>COC(=O)c1sccc1-n1nc(C(Nc2ccc(C#N)c(CNC(=O)OC(C)(C)C)c2)c2cc3c(c(OC)c2)OCOC3)[nH]c1=O,,CCN(CC)CC,,C1CCOC1,,val
US20040142982A1,COC(=O)[C@H](Cc1ccc(Nc2nc3ccncc3cc2C#N)cc1)NC(=O)OC(C)(C)C.Cl>>COC(=O)[C@@H](N)Cc1ccc(Nc2nc3ccncc3cc2C#N)cc1.Cl,,C1COCCO1,,,,val
US20090036453A1,BrCC1CC1.COCOc1cccc(Br)c1O>>COCOc1cccc(Br)c1OCC1CC1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050038031A1,O=[N+]([O-])c1cc(O)c(Cl)cc1Cl>>Nc1cc(O)c(Cl)cc1Cl,[Fe],CC(=O)O,,,,val
US20130310411A1,Clc1c2ccccc2nc2ccccc12.Sc1ccccc1Br>>Brc1ccccc1Sc1c2ccccc2nc2ccccc12,,CN(C)C=O,,[H-].[Na+],,val
US04997943,Cc1ccc(S(=O)(=O)OCC2CCN(C(=O)OC(C)(C)C)C2)cc1>>C=C1CCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,O,CC(C)(C)[O-].[K+],val
US20100227872A1,Cc1nocc1C(=O)Nc1cnc(Cl)c(N)n1.OB(O)c1cc(F)ccc1OC(F)(F)F>>Cc1nocc1C(=O)Nc1cnc(-c2cc(F)ccc2OC(F)(F)F)c(N)n1,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110275655A1,N.O=C(Cl)c1cnc(Cl)nc1Cl>>NC(=O)c1cnc(Cl)nc1Cl,,C1COCCO1,,CCOCC,,val
US04167570,CCN(CC)CCCl.Cc1ccc2c(n1)Nc1ccccc1N(C)C2=O>>CCN(CC)CCN1c2ccccc2N(C)C(=O)c2ccc(C)nc21,,CN(C)C=O,,[H-].[Na+],,val
US04014679,CCCC(CC(=O)Nc1ccccc1)(OC)OC>>CCCC(=CC(=O)Nc1ccccc1)OC,,CO,,CC(C)OC(C)C,,val
US20060084680A1,CC(=O)C(C)Br.CCCN(CCCOc1ccc2c(c1)CC[C@H]2CC(=O)OCC)c1ccc(C(N)=S)cn1>>CCCN(CCCOc1ccc2c(c1)CC[C@H]2CC(=O)OCC)c1ccc(-c2nc(C)c(C)s2)cn1,,CCO,,,,val
US20150239838A1,CC(C)(C)OC(=O)CBr.NC(=O)c1n[nH]cc1Br>>CC(C)(C)OC(=O)Cn1cc(Br)c(C(N)=O)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040242584A1,CC(N)=S.O=C(Cl)c1ccccc1C(=O)Cl>>CC(=S)N1C(=O)c2ccccc2C1=O,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20020187982A1,COC(C)(C)n1nnc(CC(=O)c2ccc(CNC3CCC(C(C)(C)C)CC3)cc2)n1.O=C=Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CC(C)(C)C1CCC(N(Cc2ccc(C(=O)Cc3nn[nH]n3)cc2)C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1,,C1CCOC1,,,,val
US04104382,CSC(=NCCSCc1[nH]cnc1C)NC#N.Cc1nc[nH]c1CSCCN>>CCNC(=NCCSCc1[nH]cnc1C)NC#N,,CCO,,,,val
US20150210688A1,Cc1cc(C)c(-c2c(C)c(Cl)nn2COCC[Si](C)(C)C)cc1C(=O)[O-]>>COC(=O)c1cc(-c2[nH]nc(Cl)c2C)c(C)cc1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110046130A1,CC(C)N1CCC(O)CC1.CN1CCc2nc(Cl)c(C#N)cc2C1>>CC(C)N1CCC(Oc2nc3c(cc2C#N)CN(C)CC3)CC1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20050227109A1,C#Cc1ccccc1.CCCC[SnH](CCCC)CCCC>>CCCC[Sn](/C=C/c1ccccc1)(CCCC)CCCC,CC(C)(C#N)N=NC(C)(C)C#N,,,,,val
US20110251204A1,CC[C@H](C)[C@@H](C=O)NC(=O)OC(C)(C)C.Nc1ccc2cc(Br)ccc2c1>>CC[C@H](C)[C@@H](CNc1ccc2cc(Br)ccc2c1)NC(=O)OC(C)(C)C,,ClCCCl,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060142360A1,N#Cc1ccc(N(CCCS(=O)(=O)c2ccc(OCc3ccccc3)cc2)n2cnnc2)cc1>>N#Cc1ccc(N(CCCS(=O)(=O)c2ccc(O)cc2)n2cnnc2)cc1,[Pd],C1CCOC1,CCO,,,val
US20130331351A1,Nc1ncnc2c1nc(Br)n2Cc1ccccc1.O=C(O)CS>>Nc1ncnc2c1nc(SCC(=O)O)n2Cc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20070032478A1,CCc1cc(C(=O)O)nn1C.Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3)c1>>CCc1cc(C(=O)Nc2cccc(C(=O)c3ccc4c(c3)NC(=O)C4)c2)nn1C,,C1CCOC1,,O=S(Cl)Cl,,val
US20140256729A1,C=Cc1ccccc1.CCO/C([O-])=C/[N+]#N>>CCOC(=O)[C@@H]1C[C@@H]1c1ccccc1,,ClC(Cl)Cl,,,,val
US20060270692A1,COc1cc2ncnc(Cl)c2cc1O.OCCCN1CCOCC1>>COc1cc2ncnc(Cl)c2cc1OCCCN1CCOCC1,,ClCCl,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130203592A1,CC(C)c1ccccc1NC(=S)N/N=C/c1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1.O=C(CBr)c1ccccc1C(F)(F)F>>CC(C)c1ccccc1N1/C(=N\N=C/c2ccc(-c3ncn(-c4ccc(OC(F)(F)F)cc4)n3)cc2)SCC1(O)c1ccccc1C(F)(F)F,,CCOC(C)=O,ClCCCl,,,val
US20120142735A1,COCCn1ccc2c(F)ccc(OC(F)(F)F)c21.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COCCn1cc(C(=O)C(F)(F)F)c2c(F)ccc(OC(F)(F)F)c21,,CN(C)C=O,,,,val
US05212187,CN(CCCCCN)CCC(c1ccc(Cl)cc1)c1ccccn1.NCCCOc1cccc(CN2CCCCC2)c1.O=C(n1ccnc1)n1ccnc1>>CN(CCCCCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1)CCC(c1ccc(Cl)cc1)c1ccccn1,,ClCCl,,,,val
US04929613,CCOC1=CC(=O)CC1.Fc1cc(Br)c(F)cc1Br>>O=C1C=C(c2cc(F)c(Br)cc2F)CC1,,CCOCC,,Cl,[Li]CCCC,val
US20120108582A1,C=CCCC12CN(Cc3ccccc3)CC1COC2=O.O=C(Cl)OCc1ccccc1>>C=CCCC12CN(C(=O)OCc3ccccc3)CC1COC2=O,,ClCCl,,,,val
US20040259907A1,Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2ccoc21.O=C1CCC(=O)N1Br>>Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(Br)oc21,,ClC(Cl)Cl,,,,val
US20100069629A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=[N+]([O-])c1cccc(NCCN2CCOCC2)c1>>CC(C)(C)OC(=O)N(CCN1CCOCC1)c1cccc([N+](=O)[O-])c1,CN(C)c1ccncc1,O,,CN(C)C=O,,val
US20100022541A1,COC(=O)CN(Cc1ccccn1)C(=O)c1nc(-c2cccc(N)c2)oc1C.O=C(Cl)C1CC1>>COC(=O)CN(Cc1ccccn1)C(=O)c1nc(-c2cccc(NC(=O)C3CC3)c2)oc1C,,ClCCl,,CCN(CC)CC,,val
US04789680,CC#CC(=O)O.CC(N=[N+]=[N-])c1c(F)cccc1F>>CC(c1c(F)cccc1F)n1cc(C(=O)O)nn1,,Cc1ccccc1,,,,val
US20080058369A1,CCOC(=O)c1c(CC)nc2c(cnn2CC)c1NC1CCOCC1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CO,,Cc1ccccc1,ClCCl,CC(C)C[Al+]CC(C)C.[H-],,val
US20040122057A1,CCOC(C(=O)NCc1ccc(C(=N)NC(=O)OCc2ccccc2)cc1)c1c(F)cc(O)cc1F.Cl>>CCOC(C(=O)NCc1ccc(C(=N)N)cc1)c1c(F)cc(O)cc1F.Cl,[Pd],CCO,,,,val
US04277486,Cc1ccc2cc(C(=O)Cn3ccnc3)ccc2c1>>Cc1ccc2cc(C(=O)Cn3ccnc3)ccc2c1,,CCOCC,,Cl,O=C([O-])[O-].[K+].[K+],val
US20070049534A1,CCCC(=O)Cl.CO.COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I.c1ccncc1>>CCCC(=O)Nc1ncc(Oc2cc(I)c(OC)cc2C(C)C)c(NC(=O)CCC)n1,,ClCCl,,C[Si](C)(C)Cl,,val
US20090054644A1,CC(Oc1ccc(C(F)(F)F)cc1)C1CNCC1c1ccc(Cl)c(Cl)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(Oc1ccc(C(F)(F)F)cc1)C1CN(C(=O)Cl)CC1c1ccc(Cl)c(Cl)c1,,ClCCl,,c1ccncc1,,val
US04956372,CC(=O)Cl.Nc1cc2c(c(C(=O)O)c1)NCCC2>>CC(=O)Nc1cc2c(c(C(=O)O)c1)NCCC2,,C1COCCO1,,[Na+].[OH-],,val
US20150104384A1,Nc1ccc(C(=O)O)cn1.O=CCCl>>Cl.O=C(O)c1ccc2nccn2c1,,CCO,,,,val
US20150126490A1,CC1(c2ccc(F)nc2)CCOCC1.COc1ccc(CN)c(OC)c1>>COc1ccc(CNc2ccc(C3(C)CCOCC3)cn2)c(OC)c1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,O=C([O-])[O-].[K+].[K+],val
US20110034450A1,CC(=O)c1ccccc1.NN.O=CC(=O)O>>O=c1ccc(-c2ccccc2)n[nH]1,,O,,N,,val
US20110263562A1,CC(=O)Oc1ccc(OC[C@H](C)NC(=O)OC(C)(C)C)cc1>>C[C@@H](COc1ccc(O)cc1)NC(=O)OC(C)(C)C,,CO,,O=C([O-])[O-].[K+].[K+],,val
US06358554B1,CC(=O)O.O=C(O)CC(O)C(=O)O>>O=C(O)CC(O)(CC(=O)O)C(=O)O,,CC(=O)O,,,,val
US20100204240A1,Cc1ncccc1Oc1cc(Sc2ccccn2)cnc1Nc1nc([C@]2(C)COC(C)(C)O2)ns1.Cl>>Cc1ncccc1Oc1cc(Sc2ccccn2)cnc1Nc1nc([C@@](C)(O)CO)ns1.Cl,,CCO,,,,val
US20140163002A1,CC(C)(C)OC(=O)CBr.COc1cccc(C=O)c1F>>COc1cccc(C(O)CC(=O)OC(C)(C)C)c1F,[Zn],C1CCOC1,,C[Si](C)(C)Cl,,val
US20090305998A1,COc1cccc(B2OCCN(c3ccccc3)CCO2)n1.Cc1nc(N)nc2c1C(NOC1CCCCO1)=N[C@@H](c1ccc(F)cc1Br)C2>>COc1cccc(-c2cc(F)ccc2[C@H]2Cc3nc(N)nc(C)c3C(NOC3CCCCO3)=N2)n1,,CC(=O)N(C)C,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20160248023A1,Brc1ccc2c(c1)c1ccccc1n2-c1ccccc1.OB(O)c1cccc2c1oc1ccccc12.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>c1ccc(-c2ccc3c(c2)c2cc(-c4cccc5c4oc4ccccc45)ccc2n3-c2ccccc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20100168418A1,CNC(=O)c1cc(=O)n(CCN2CCC(NCc3cc(-c4cccs4)on3)CC2)c2ccccc12.Cl>>CNC(=O)c1cc(=O)n(CCN2CCC(NCc3cc(-c4cccs4)on3)CC2)c2ccccc12.Cl,,CCOC(C)=O,,,,val
US20110105509A1,Fc1ccc(CBr)c(F)c1.NN>>NNCc1ccc(F)cc1F,,CO,,,,val
US20020061872A1,Cc1nc(NC(=O)OC(C)(C)C)ccc1CN.O=C(O)Cc1c(Cl)ccc(NCC(F)(F)c2ccccc2)c1F>>Cc1nc(NC(=O)OC(C)(C)C)ccc1CNC(=O)Cc1c(Cl)ccc(NCC(F)(F)c2ccccc2)c1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US06956050B2,CC(Br)C(=O)c1ccccc1.Nc1ccc(CCO)cc1>>CC(Nc1ccc(CCO)cc1)C(=O)c1ccccc1,,CN(C)C=O,,,,val
US20040092507A1,C1CNCCN1.NS(=O)(=O)c1ccccc1F>>NS(=O)(=O)c1ccccc1N1CCNCC1,,C1COCCO1,,,,val
US20110082135A1,CCC(=O)NNc1ccc2[nH]c(=O)c(-c3ccccc3)cc2n1>>CCc1nnc2ccc3[nH]c(=O)c(-c4ccccc4)cc3n12,,CC(=O)O,,,,val
US20050130941A1,C=C[C@@H](N)Cc1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>C=C[C@H](Cc1ccccc1)NC(=O)C(F)(F)F,,ClCCl,c1ccncc1,,,val
US04600758,CC(C)(C)N(C(=O)[O-])C1CCN(Cc2ccccc2)CC1.CC(C)(C)N(C(=O)[O-])C1CCNCC1>>CC(C)(C)OC(=O)NC1CCNCC1,[Pd],CCO,,CC(=O)O,,val
US20140349998A1,C=C(C)C(=O)Nc1cccc(-c2ncnc3c2c(Br)cn3COCC[Si](C)(C)C)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>C=C(C)C(=O)Nc1cccc(-c2ncnc3c2c(B2OC(C)(C)C(C)(C)O2)cn3COCC[Si](C)(C)C)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC(=O)N(C)C,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US03992384,CC(N)c1cccc2ccccc12.O=C(Cl)c1ccc(Cl)cc1>>CC(NC(=O)c1ccc(Cl)cc1)c1cccc2ccccc12,,c1ccccc1,,CCN(CC)CC,,val
US20080119476A1,COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN[C@@H](C)[C@H](N)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)N[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20110172245A1,CC(C)(C)OC(=O)Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)[nH]c3c2)c1>>Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)[nH]c3c2)c1,,O=C(O)C(F)(F)F,,,,val
US20160200704A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(N)nc(C)c1C#N>>Cc1cc(N)nc(C)c1CNC(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20120040954A1,C1CCNC1.Cc1cc(-c2nc3cc(OC(C)C)cc(OC(C)C)c3c(=O)[nH]2)cc(C)c1OCCBr>>Cc1cc(-c2nc3cc(OC(C)C)cc(OC(C)C)c3c(=O)[nH]2)cc(C)c1OCCN1CCCC1,,CN(C)C=O,,O,,val
US20130217668A1,C1CCNCC1.COC(=O)[C@H]1CC[C@@H](n2c(NC(=O)c3ccc(F)cc3)nc3ccc(CO)cc32)CC1>>COC(=O)[C@@H]1CC[C@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCCCC4)cc32)CC1,,CS(C)=O,ClCCl,O=S(Cl)Cl,,val
US06011174,CCN(CC)CC.COC(=O)c1ccc(CO)cc1C(=O)OC>>COC(=O)c1ccc(CC#N)cc1C(=O)OC,,CCOC(C)=O,,CS(=O)(=O)Cl,,val
US20080207685A1,COC(=O)C(C)N.O=C(Cl)c1ccc(C(F)(F)F)cc1>>COC(=O)C(C)NC(=O)c1ccc(C(F)(F)F)cc1,,ClCCl,O,CCN(CC)CC,Cl,val
US20130109667A1,COc1ccc(CN(c2ncc(F)cn2)S(=O)(=O)c2cc(Cl)c(F)cc2F)c(OC)c1.Nc1cc(-c2cc(C(F)(F)F)ccc2O)ccn1>>COc1ccc(CN(c2ncc(F)cn2)S(=O)(=O)c2cc(Cl)c(Oc3ccc(C(F)(F)F)cc3-c3ccnc(N)c3)cc2F)c(OC)c1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US06300363B1,CC(=O)Nc1c(C(=O)c2cccc(OCc3ccccc3)c2)[nH]c2cc(Cl)ccc12>>CC(=O)Nc1c(C(=O)c2cccc(O)c2)[nH]c2cc(Cl)ccc12,[Pd],CCO,CCOC(C)=O,,,val
US20090143372A1,CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(B4OC(C)(C)C(C)(C)O4)cc23)CC1.O=Cc1cnc(Br)s1>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ncc(C=O)s4)cc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20060122268A1,COC(=O)c1ccc(C=O)cc1.Cl[Mg]c1ccccc1>>COC(=O)c1ccc(C(O)c2ccccc2)cc1,,ClCCl,,C1CCOC1,,val
US20080176830A1,Nc1ccc(I)cc1F.OB(O)c1ccc(C(F)(F)F)cc1>>Nc1ccc(-c2ccc(C(F)(F)F)cc2)cc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05025036,CCCCCCI.CCCc1c(OCCCCCCc2cccc(O)c2O)ccc(C(=O)O)c1O>>CCCCCCOC(=O)c1ccc(OCCCCCCc2cccc(O)c2O)c(CCC)c1O,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US04550111,NCCNC(=O)c1nc(Cl)c(N)nc1N.O=C(O)C(=O)O.c1cc(OCC2CO2)c2cc[nH]c2c1>>Nc1nc(N)c(C(=O)NCCNCC(O)COc2cccc3[nH]ccc23)nc1Cl.O=C(O)C(=O)O,,CO,,CC(C)O,,val
US03947434,COc1ccc(OC(C)=O)cc1.O=[N+]([O-])O>>COc1ccc(OC(C)=O)cc1[N+](=O)[O-],,CC(=O)O,,,,val
US20080280875A1,COC(=O)c1ccc(Oc2cc(C(=O)Nc3ccn(C)n3)cc3c2CC(C)(C)O3)cn1>>Cn1ccc(NC(=O)c2cc(Oc3ccc(C(=O)O)nc3)c3c(c2)OC(C)(C)C3)n1,,C1CCOC1,,[Na+].[OH-],,val
US20090253684A1,CN(C)C(OC(C)(C)C)OC(C)(C)C.O=C(O)c1cc(OCc2ccccc2)cc(-c2cccc(F)c2)c1>>CC(C)(C)OC(=O)c1cc(OCc2ccccc2)cc(-c2cccc(F)c2)c1,,CCOC(C)=O,Cc1ccccc1,,,val
US06277862B1,CCOC(=O)Cl.CC[C@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1>>CCOC(=O)Oc1c(-c2ccccc2)nc2ccccc2c1C(=O)N[C@@H](CC)c1ccccc1,,c1ccncc1,,,,val
US20120277229A1,O=C(Nc1ccc2c(c1)c(-c1nc3ccccc3[nH]1)nn2C1CCCCO1)C1CC1>>O=C(Nc1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1)C1CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060074111A1,CCCCNCc1ccc(OCC(=O)OCC)c(C)c1.Cc1ccc(-c2cncc(Br)n2)cc1>>CCCCN(Cc1ccc(OCC(=O)OCC)c(C)c1)c1cncc(-c2ccc(C)cc2)n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150366977A1,NO.O=S(=O)(Cl)c1cccc(OC(F)(F)F)c1>>O=S(=O)(NO)c1cccc(OC(F)(F)F)c1,,C1CCOC1,,O,,val
US20090163488A1,CC(C)(C)OC(=O)Nc1cccc(O)c1.O=[N+]([O-])c1ccc(Br)cn1>>CC(C)(C)OC(=O)Nc1cccc(Oc2ccc([N+](=O)[O-])nc2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090258866A1,OC1(c2cccc(F)c2F)CCC=CCC1>>Fc1cccc(C2CCC=CCC2)c1F,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US06756373B1,CC(C)COc1ncccc1C(=O)O.NC(=O)CCC(=O)NI>>CC(C)COc1ncc(I)cc1C(=O)O,,O=C(O)C(F)(F)F,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20070049618A1,O=[N+]([O-])c1ccc(OCCN2CCOCC2)cc1F>>Nc1ccc(OCCN2CCOCC2)cc1F,[Pd],CCOC(C)=O,,[H][H],,val
US20090291971A1,Cc1noc(C)c1B(O)O.c1ccc2c(On3nnc4cccnc43)ncnc2c1>>Cc1noc(C)c1Oc1ncnc2ccccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120046307A1,CCOC(=O)CC(c1ccc(Cl)cc1)c1nc2ccc(Cl)cc2[nH]1.Cl>>Cl.O=C(O)CC(c1ccc(Cl)cc1)c1nc2ccc(Cl)cc2[nH]1,,CC(=O)O,Cl,,,val
US20150011528A1,COC(=O)C(Br)CO.O=C(Nc1nc2ccccc2s1)c1cccc(C(F)(F)F)c1>>COC(=O)C(CO)n1c(=NC(=O)c2cccc(C(F)(F)F)c2)sc2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110136764A1,C#CCNC.O=C(O)c1c(Cl)ncnc1Cl>>C#CCN(C)C(=O)c1c(Cl)ncnc1Cl,,CN(C)C=O,ClCCl,CCN(CC)CC,O=S(Cl)Cl,val
US20030216430A1,COc1cccc(C2(O)CCN(CC(=O)c3ccc4c(c3F)CCC(=O)N4)CC2)c1>>COc1cccc(C2(O)CCN(CC(O)c3ccc4c(c3F)CCC(=O)N4)CC2)c1,,CCO,,O,[BH4-].[Na+],val
US20100240634A1,CCOC(=O)COC1(C(F)(F)F)c2ccccc2-c2c(Cl)cc(F)cc21>>O=C(O)COC1(C(F)(F)F)c2ccccc2-c2c(Cl)cc(F)cc21,,CCO,,[Na+].[OH-],,val
US20140066422A1,COc1ccc(Oc2ncc(NCCNC(=O)OC(C)(C)C)c(Oc3ccc(OC)cc3)n2)cc1>>COc1ccc(Oc2ncc(NCCN)c(Oc3ccc(OC)cc3)n2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04978665,CCOc1cc(CNc2c(OC(C)CC)nn(COCC[Si](C)(C)C)c(=O)c2Cl)ccc1OC>>CCOc1cc(CNc2c(OC(C)CC)n[nH]c(=O)c2Cl)ccc1OC,,COCCOC,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04863503,COC(=O)Cc1cccn1C.COC=O>>COC(=O)C(=CO)c1cccn1C,,CN(C)C=O,,[H-].[Na+],O=C([O-])[O-].[K+].[K+],val
US20070135645A1,CN(C)[C+](Cl)N(C)C.CN(C)[Si](C)(C)C.O=P([O-])(C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)F>>CN(C)C(N(C)C)=[N+](C)C.O=P([O-])(C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)F,,ClC(Cl)Cl,,,,val
US20080312231A1,CCOC(=O)/C=C\C(=O)OCC.Nc1ccccc1N>>COC(=O)CC1Nc2ccccc2NC1=O,,CCCO,,,,val
US20120101147A1,C#Cc1ccc(NC(=O)OC(C)(C)C)c(NC(=O)/C=C/c2ccc(NC(C)=O)cc2)c1>>C#Cc1ccc(N)c(NC(=O)/C=C/c2ccc(NC(C)=O)cc2)c1,,C1COCCO1,,O=S(=O)(O)O,,val
US20150353553A1,Cc1cccc(C(=O)Nc2c(NCc3ccc(C(F)(F)F)cc3)c(=O)[nH]c(=O)n2C)c1>>Cc1cccc(-c2nc3c(c(=O)[nH]c(=O)n3C)n2Cc2ccc(C(F)(F)F)cc2)c1,,CCO,,[Na+].[OH-],,val
US20100121048A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2nnn(-c3cccc(O)c3)c2-c2ccccc2)[C@H](Cc2ccccc2)C1.O=S1(=O)CCN(CCO)CC1>>CC(C)(C)OC(=O)N1CCN(C(=O)c2nnn(-c3cccc(OCCN4CCS(=O)(=O)CC4)c3)c2-c2ccccc2)[C@H](Cc2ccccc2)C1,,Cc1ccccc1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070197581A1,C/C=C/C(=O)OC.O=S(=O)(Cc1c(F)ccc(F)c1F)c1ccc(Cl)cc1>>COC(=O)CC(C)C(c1c(F)ccc(F)c1F)S(=O)(=O)c1ccc(Cl)cc1,,C1CCOC1,CCOC(C)=O,O,CC(C)(C)[O-].[K+],val
US20040162321A1,O=Cc1cccc2c1OCO2.[Li]C>>CC(O)c1cccc2c1OCO2,,C1CCOC1,CCOCC,,,val
US20110313032A1,CO.O=C(O)[C@@]1(O)C[C@@H](O)[C@H](O)c2sccc21.O=C1O[C@@H]2C[C@@]1(O)c1cc(Cc3ccccc3)sc1[C@H]2O>>O=C(O)[C@@]1(O)C[C@@H](O)[C@H](O)C2=C1CC(Cc1ccccc1)(Cc1ccccc1)S2,,CO,,[Li+].[OH-],,val
US20110178308A1,Br.O=[N+]([O-])c1c[nH]c([N+](=O)[O-])n1>>O=[N+]([O-])c1c[nH]c(Br)n1,,Cc1ccc(C)cc1,,O=C([O-])O.[Na+],,val
US20110053936A1,CCO/C=C/B(/C=C/OCC)/C=C/OCC.Nc1cc(Cl)ncc1I>>CCO/C=C/c1cnc(Cl)cc1N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,O,[Na+].[OH-],val
US20100081643A1,COC(=O)c1cc(Oc2nc3cc(-c4ccc5ccccc5c4)c(Cl)cc3[nH]2)ccc1C>>Cc1ccc(Oc2nc3cc(-c4ccc5ccccc5c4)c(Cl)cc3[nH]2)cc1C(=O)O,,CO,,[Na+].[OH-],,val
US04900472,CCCCc1ccc(-c2cnc(-c3ccc(OCc4ccccc4)cc3)nc2)cc1>>CCCCc1ccc(-c2cnc(-c3ccc(O)cc3)nc2)cc1,[Pd],CCOC(C)=O,,CCN(CC)CC,CCO,val
US20030073710A1,Cc1cc(C)nc(NS(=O)(=O)c2ccc(NC(=O)c3c(Cl)cccc3Cl)cc2)n1>>Cc1cc(C)nc(NS(=O)(=O)c2ccc(NC(O)c3c(Cl)cccc3Cl)cc2)n1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100305122A1,CC(C)(C)OC(=O)N1CCC(O)(Cc2ccccc2O)CC1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCC(O)(Cc2ccccc2OS(=O)(=O)C(F)(F)F)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080058358A1,CC(C)N.Clc1ccnc(Cl)n1>>CC(C)Nc1ccnc(Cl)n1,,CC#N,,CCN(CC)CC,,val
US20060094767A1,CC(=O)CN1CCN(C(=O)OCc2ccccc2)CC1.C[S+](C)(C)=O>>CC1(CN2CCN(C(=O)OCc3ccccc3)CC2)CO1,,CS(C)=O,,[H-].[Na+],,val
US20040072820A1,COc1cccc(-c2ccc3cc(OC)ccc3c2OC(C)=O)c1>>COc1cccc(-c2ccc3cc(OC)ccc3c2O)c1,,CO,,Cl,,val
US20100120841A1,O=C1Cc2cccc3ccc(Cl)c1c23>>OC1Cc2cccc3ccc(Cl)c1c23,,CO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20120115846A1,CCOC(=O)c1cc(OCc2ccccc2)c(F)cc1NC1CCOCC1>>O=C(O)c1cc(OCc2ccccc2)c(F)cc1NC1CCOCC1,,CC(C)O,O,[K+].[OH-],,val
US20150368228A1,CC(C)S(=O)(=O)c1ccc(Br)cn1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(C)S(=O)(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cn1,,C1COCCO1,CCOC(C)=O,CC(=O)[O-].[K+],,val
US20060079505A1,OCC1=CCN(Cc2ccccc2)CC1.Oc1ccc(Cl)cc1I>>Clc1ccc(OCC2=CCN(Cc3ccccc3)CC2)c(I)c1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120083502A1,C[Mg]Br.Cc1cccc2nc(C=O)c(Br)c(=O)n12>>Cc1cccc2nc(C(C)O)c(Br)c(=O)n12,,C1CCOC1,,CCOCC,,val
US20130018064A1,CC(=Cc1cc2cc(-c3ccccc3C)ccc2nc1Cl)c1cncc(Br)c1.COc1ccc(CN)cc1>>COc1ccc(CNc2nc3ccc(-c4ccccc4C)cc3cc2C=C(C)c2cncc(Br)c2)cc1,,O,,CN1CCCC1=O,,val
US20100261702A1,CCN(CC)Cc1sc(-c2nc(-c3ccc(CN)cc3)no2)cc1C.CS(=O)(=O)Cl>>CCN(CC)Cc1sc(-c2nc(-c3ccc(CNS(C)(=O)=O)cc3)no2)cc1C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06291455B1,COc1cc2ncnc(Cl)c2cc1OC.Cl.Nc1cc(O)ccc1F>>COc1cc2ncnc(Nc3cc(O)ccc3F)c2cc1OC.Cl,,CC(C)O,,,,val
US20150299188A1,COCCBr.O=C1Nc2ccnc(Cl)c2CN1c1cc2c(cc1Cl)CCC(c1ncccc1F)O2>>COCCN1C(=O)N(c2cc3c(cc2Cl)CCC(c2ncccc2F)O3)Cc2c1ccnc2Cl,,CN(C)C=O,,O,[H-].[Na+],val
US20120027874A1,CN(Cc1ccc(C=NO)c(F)c1)C(=O)OC(C)(C)C.O=C1CCC(=O)N1Cl>>CN(Cc1ccc(C(Cl)=NO)c(F)c1)C(=O)OC(C)(C)C,,CN(C)C=O,,,,val
US20090312383A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccc(C(F)(F)F)c2[nH]c(=O)[nH]c12>>COC(=O)c1ccc(C(F)(F)F)c2c1[nH]c(=O)n2C(=O)OC(C)(C)C,,CN(C)C=O,,Cl,[H-].[Na+],val
US20130059849A1,C/C(N)=C/C#N.NNC1CCCC1>>Cc1cc(N)n(C2CCCC2)n1,,CCO,,Cl,,val
US20070185037A1,C=CCO[C@H]1[C@H](OC(=O)c2ccccc2)[C@@H](COC(=O)c2ccccc2)O[C@H](O[C@H]2[C@H](OC(=O)c3ccccc3)[C@@H](COC(=O)c3ccccc3)O[C@H](O[C@@H]3[C@@H](OCc4ccccc4)O[C@H](COCc4ccccc4)[C@@H](OCc4ccccc4)[C@@H]3OCc3ccccc3)[C@H]2OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1.CO>>O=C(OC[C@H]1O[C@H](O[C@@H]2[C@@H](OCc3ccccc3)O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)[C@@H](OC(=O)c2ccccc2)[C@@H](O[C@H]2O[C@H](COC(=O)c3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@H](O)[C@@H]2OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1)c1ccccc1,Cl[Pd]Cl,CO,ClCCCl,,,val
US20090082379A1,CC(C)(C)c1ccc(N2C(=O)N(Cc3ccn4oc(=S)nc4c3)C(C)(C)C2=O)cc1.CCCCN>>CCCCNC(=O)Nc1cc(CN2C(=O)N(c3ccc(C(C)(C)C)cc3)C(=O)C2(C)C)ccn1,,C1COCCO1,,,,val
US20090239848A1,CCC(C(=O)Cl)C(=O)Cl.Nc1nc(-c2ccccc2)cs1.O>>CCOC(=O)CC(=O)Nc1nc(-c2ccccc2)cs1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US05106871,CC(=O)OC(C)=O.COCOc1ccc(C=CC(=O)c2c(OCOC)cc(OCOC)c(CC=C(C)C)c2O)cc1>>COCOc1ccc(C=CC(=O)c2c(OCOC)cc(OCOC)c(CC=C(C)C)c2OC(C)=O)cc1,,c1ccncc1,,O=C([O-])O.[Na+],,val
US20020169317A1,CCNCC.ClCCCOc1cccc2c1c1cccc3c1n2C(c1ccccc1)CO3>>CCN(CC)CCCOc1cccc2c1c1cccc3c1n2C(c1ccccc1)CO3,,CN(C)C=O,,[I-].[Na+],,val
US06143779,COc1ccc(C=C2Oc3cc(O)ccc3C2=O)cc1C.O=C(Cl)c1ccccc1>>COc1ccc(C=C2Oc3cc(OC(=O)c4ccccc4)ccc3C2=O)cc1C,,c1ccncc1,,CCOC(C)=O,,val
US20080051405A1,CC(C)(C)OC(=O)N1CCCC[C@H]1COc1cccc(CO)n1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCCC[C@H]1COc1cccc(COS(C)(=O)=O)n1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20100179141A1,CS(=O)(=O)c1ccc(-n2cc(CN=[N+]=[N-])cn2)cc1>>CS(=O)(=O)c1ccc(-n2cc(CN)cn2)cc1,,C1COCCO1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100216860A1,CC(=O)OC(C)=O.NCc1cccc(Cn2nc(N(S(=O)(=O)c3ccc(Cl)s3)S(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1>>CC(=O)NCc1cccc(Cn2nc(N(S(=O)(=O)c3ccc(Cl)s3)S(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1,,ClCCl,,CCN(CC)CC,,val
US20070123535A1,C1N2CN3CN1CN(C2)C3.O.c1cnc2cc[nH]c2c1>>O=Cc1c[nH]c2cccnc12,,O,,CC(=O)O,,val
US20050009840A1,Nc1ncc(Br)cc1OCc1ccccc1Cl.O=C(O)c1ccc(B(O)O)cc1>>Nc1ncc(-c2ccc(C(=O)O)cc2)cc1OCc1ccccc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070167622A1,CC1CCCC(C)N1.O=C(O)c1csc(Br)n1>>CC1CCCC(C)N1C(=O)c1csc(Br)n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US08138168B1,CC(C)(C)OC(=O)N1CCCC(c2nc3ccccc3n2CCN2C(=O)c3ccccc3C2=O)C1>>O=C1c2ccccc2C(=O)N1CCn1c(C2CCCNC2)nc2ccccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160244475A1,CC1(C)O[C@@H]2[C@@H](C(=O)c3ccc(Cl)c(F)c3)O[C@@H](n3ccc4c(Cl)ncnc43)[C@@H]2O1.C[Mg]Br>>CC1(C)O[C@@H]2[C@@H]([C@](C)(O)c3ccc(Cl)c(F)c3)O[C@@H](n3ccc4c(Cl)ncnc43)[C@@H]2O1,,C1CCOC1,,[Cl-].[NH4+],,val
US20140315961A1,CCOC(=O)c1ncoc1-c1ccc(C#N)cc1>>N#Cc1ccc(-c2ocnc2C=O)cc1,,C1CCOC1,Cc1ccccc1,CC(C)C[AlH]CC(C)C,,val
US20060276496A1,C=C(C)C#N.CCOC(=O)CC(=O)OCC>>CCOC(=O)C(CC(C)C#N)C(=O)OCC,,CCO,O,CC(=O)O,[Na],val
US20130109682A1,CC(=O)OC(C)=O.O=[N+]([O-])c1cnccc1[C@H]1C[C@@H](O)[C@@]2(O)CCC[C@H]2O1>>CC(=O)O[C@@H]1C[C@H](c2ccncc2[N+](=O)[O-])O[C@@H]2CCC[C@]12O,,c1ccncc1,,,,val
US20110015240A1,CC(=O)Nc1nc(CCc2ccc(CO)cc2)cs1.CC(C)(C)OC(=O)NN.O=C(n1ccnc1)n1ccnc1>>CC(=O)Nc1nc(CCc2ccc(COC(=O)NNC(=O)OC(C)(C)C)cc2)cs1,,C1CCOC1,,,,val
US20060223760A1,O=C1NC(=O)C(c2cn3c4c(cccc24)CCC3)=C1c1c[nH]c2ccc(-c3ccccc3)cc12>>O=C1NC(=O)[C@@H](c2c[nH]c3ccc(-c4ccccc4)cc23)[C@@H]1c1cn2c3c(cccc13)CCC2,,CO,,,,val
US04299838,CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.NCCO>>CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.NCCO,,CCO,,,,val
US20100222303A1,C=CCC(CC(=O)NC(Cc1ccc(OC(C)(C)C)cc1)C(=O)N(Cc1cccc2cn[nH]c12)CC(OCC)OCC)NC(=O)NCc1ccccc1>>C=CCC1CC(=O)N2C(Cc3ccc(O)cc3)C(=O)N(Cc3cccc4cn[nH]c34)CC2N1C(=O)NCc1ccccc1,,O=CO,,,,val
US20110294793A1,COC(=O)c1cccc(CN(Cc2ccc(F)cc2)S(=O)(=O)c2cc(Cl)cc(Cl)c2O)n1>>O=C(O)c1cccc(CN(Cc2ccc(F)cc2)S(=O)(=O)c2cc(Cl)cc(Cl)c2O)n1,,CO,,C1CCOC1,[Na+].[OH-],val
US20110028390A1,CCI.CCOC(=O)c1cc(O)c2[nH]ncc2c1>>CCOC(=O)c1cc(OCC)c2[nH]ncc2c1,,CN(C)C=O,,[H-].[Na+],,val
US20060211734A1,CC1CC(Oc2cccc(N)n2)CCN1C(=O)OC(C)(C)C.O=C(Cl)c1c(F)cccc1Cl>>CC1CC(Oc2cccc(NC(=O)c3c(F)cccc3Cl)n2)CCN1C(=O)OC(C)(C)C,,C1COCCO1,,CCN(CC)CC,,val
US20150175602A1,CC1Cc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2CN1.O=C(O)C(F)(F)F.O=C(O)C1CC1>>CC1Cc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2CN1C(=O)C1CC1.O=C(O)C(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150094306A1,COc1cc(C(C)=O)cnc1Cl.OCC(F)(F)F>>COc1cc(C(C)=O)cnc1OCC(F)(F)F,,C1CCOC1,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US04602014,CCOC(=O)c1cnc2c(c1Cl)CCCC2.NNc1ccc(Cl)cc1>>Cl.O=c1c2c[nH]c3c(c-2nn1-c1ccc(Cl)cc1)CCCC3,,CCCCO,,,,val
US20160176868A1,CCOC(=O)C[C@@H](N)c1cccc(Cl)c1.CCn1c(=O)cc(Cl)[nH]c1=O>>CCOC(=O)C[C@@H](Nc1cc(=O)n(CC)c(=O)[nH]1)c1cccc(Cl)c1,,CN(C)C=O,ClCCl,,,val
US20020177613A1,CC(N)C(C)(C)C.CCOc1c(C(C(C)=O)c2ccc(C(F)(F)F)cc2)c(=O)c1=O>>CC(Nc1c(C(CC=O)c2ccc(C(F)(F)F)cc2)c(=O)c1=O)C(C)(C)C,,CCO,,CCOCC,,val
US20010020079A1,C=C(C)C(=O)Cl.Cl.NCCN>>C=C(C)C(=O)NCCN.Cl,,ClC(Cl)Cl,O,,,val
US20050038035A1,Cc1ccc(C)n1-c1cccc(CCCOc2ccc([N+](=O)[O-])cc2)n1>>Cc1ccc(C)n1-c1cccc(CCCOc2ccc(N)cc2)n1,[Pd],C1CCOC1,CO,[H][H],,val
US20020132812A1,FC(F)(F)c1cccc(C(=CC2=NCCN2)c2ccc3ccccc3n2)c1>>FC(F)(F)c1cccc(C(CC2=NCCN2)c2ccc3ccccc3n2)c1,[Pd],CCO,,,,val
US20100003305A1,COC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C>>CC(C)[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)O,,C1CCOC1,,Cl,[Li+].[OH-],val
US20150210687A1,Cc1cccc(Cl)c1CBr.Fc1cccc2[nH]nc(I)c12>>Cc1cccc(Cl)c1Cn1nc(I)c2c(F)cccc21,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160137584A1,BrCCCCBr.OCCCCCOC1CCCCO1>>BrCCCCOCCCCCOC1CCCCO1,,C1CCOC1,,O,[H-].[Na+],val
US05134111,CCCc1cccc2c(/C=C(\C)C(=O)OCC)cc(OC)c(OCOC)c12>>CCCc1cccc2c(/C=C(\C)C(=O)O)cc(OC)c(OCOC)c12,,CCO,,Cl,[Na+].[OH-],val
US20100297035A1,CCn1cc(C(O)C2CCN(C3CCC3)CC2)nc1-c1cccc2ccccc12.CI>>CCn1cc(C(OC)C2CCN(C3CCC3)CC2)nc1-c1cccc2ccccc12,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US05516774,Cc1ccccc1C(=O)Cl.Nc1ccc(C(=O)N2Cc3cccn3-c3ccccc32)cc1>>Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3-c3ccccc32)cc1,,ClCCl,,CCN(CC)CC,,val
US20060148858A1,CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.CCOC(=O)CCc1cccc(OC)c1O>>COc1cccc(CCC(=O)O)c1OCCCc1cn(-c2ccc(C(F)(F)F)cn2)nc1C(C)C,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20090093483A1,COC(=O)C1(c2ccccc2)CCOCC1>>O=C(O)C1(c2ccccc2)CCOCC1,,CCO,CCOCC,[K+].[OH-],,val
US20080042129A1,O=C1CCC(=O)N1Br.c1csc(-c2ccsc2-c2cccs2)c1>>Brc1ccsc1-c1sccc1-c1cccs1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US04539419,COC(=O)CBr.Oc1cc(O)c2ccccc2c1>>COC(=O)COc1cc(O)c2ccccc2c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120259123A1,CCCCC(C)(C)c1ccc(CNCc2cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)cc1.COc1ccc(S(=O)(=O)Cl)cc1>>CCCCC(C)(C)c1ccc(CNC(c2cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)S(=O)(=O)c2ccc(OC)cc2)cc1,,O,,CCN(CC)CC,ClCCl,val
US20140315917A1,Cc1cc(I)nc(C)c1O.Clc1ccnc(Cl)c1>>Cc1cc(I)nc(C)c1Oc1ccnc(Cl)c1,,CC(=O)N(C)C,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20090247519A1,NC(=O)[C@H](N)CC1CCCCC1>>NC[C@H](N)CC1CCCCC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160159837A1,CC(C)(C)c1ccc(O)c(C(C)(C)C)c1.ClP1OC(c2ccccc2)(c2ccccc2)C(c2ccccc2)(c2ccccc2)O1>>CC(C)(C)c1ccc(OP2OC(c3ccccc3)(c3ccccc3)C(c3ccccc3)(c3ccccc3)O2)c(C(C)(C)C)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US04939256,N[C@H]1CCNC1.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>N[C@H]1CCNC1.O=C(O)[C@H](O)[C@@H](O)C(=O)O,,O,,CO,,val
US20100261698A1,Cn1c(-c2cncc(C(N)(C(=O)OC(C)(C)C)S(C)(=O)=O)c2)cc2ccccc21.O=C=NS(=O)(=O)Cl>>Cn1c(-c2cncc(C(N)(C(=O)OC(C)(C)C)S(C)(=O)=O)c2)c(C#N)c2ccccc21,,ClCCl,,CN(C)C=O,,val
US20150094308A1,N.Oc1nc(-c2nn(Cc3ccccc3F)c3ncccc23)nnc1C1CCCC1>>Nc1nc(-c2nn(Cc3ccccc3F)c3ncccc23)nnc1C1CCCC1,,CC#N,,O=P(Cl)(Cl)Cl,,val
US20090137572A1,CNS(=O)(=O)c1cccc(NC(=N)N)c1.Cc1nc(N=CN(C)C)sc1C(=O)C=CN(C)C>>CNS(=O)(=O)c1cccc(Nc2nccc(-c3sc(N)nc3C)n2)c1,,CC#N,,,,val
US20140228343A1,CNC.Clc1ncc(Br)cn1>>CN(C)c1ncc(Br)cn1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20140350002A1,C[C@@H](CCN)c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C.O=C(O)c1ccon1>>C[C@H](CCNC(=O)c1ccon1)c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050176786A1,NC(=S)Nc1cc(-c2ccccc2Br)n[nH]1>>Nc1nc2[nH]nc(-c3ccccc3Br)c2s1,,CC(=O)O,,BrBr,,val
US05064861,CCC(C)c1cc(Cl)cc(Cl)c1OCC(=O)NCCCCNC(=O)OC(C)(C)C>>CCC(C)c1cc(Cl)cc(Cl)c1OCC(=O)NCCCCN,,CCO,,Cl,,val
US20070167622A1,CC1CCCCN1C(=O)c1csc(I)n1.COc1ccccc1B(O)O>>COc1ccccc1-c1nc(C(=O)N2CCCCC2C)cs1,,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20150284395A1,CCOC(=O)c1c(C)cnn1C>>Cc1cnn(C)c1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060004030A1,CNC.O=C(Cl)c1c(Cl)nc(Cl)nc1Cl>>CN(C)C(=O)c1c(Cl)nc(Cl)nc1Cl,,ClCCl,O,O=C([O-])O.[Na+],,val
US20070043072A1,CN(C)c1ccc(-c2cnc(N)c([N+](=O)[O-])c2)cc1>>CN(C)c1ccc(-c2cnc(N)c(N)c2)cc1,[Pd],CO,,[H][H],,val
US20050148624A1,CCI.COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(O)cc1>>CCOc1ccc(Cn2c(C(=O)OC)c(-c3ccccc3)c3cc(Br)ccc3c2=O)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050032873A1,NC(=O)c1ccc(F)c2c1CC(NCCC(=O)c1cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc13)CO2>>NC(=O)c1ccc(F)c2c1CC(NCCC(=O)c1c[nH]c3ccc(F)cc13)CO2,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US04683000,COC(=O)Nc1nc(C)cc(OC)n1.NS(=O)(=O)c1cccc2cc[nH]c12>>COc1cc(C)nc(NC(=O)NS(=O)(=O)c2cccc3cc[nH]c23)n1,,Cc1ccccc1,ClCCl,C[Al](C)C,Cl,val
US20040097524A1,Clc1nc(-c2ccco2)c2scc(Br)c2n1.NCCO>>OCCNc1nc(-c2ccco2)c2scc(Br)c2n1,,CN1CCCC1=O,,O,,val
US20160096827A1,N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)cc(F)c1O[C@H]1CCNC[C@H]1F.O=C1N[C@H](C(=O)O)CS1>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@H]1CCN(C(=O)[C@@H]2CSC(=O)N2)C[C@H]1F,,CN(C)C=O,ClCCl,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20100331315A1,O=C(Cl)C1CC1.O=C1NC(=O)/C(=C/c2ccc(F)c(-c3cncc(N4CCCNCC4)n3)c2)S1>>O=C1NC(=O)/C(=C/c2ccc(F)c(-c3cncc(N4CCCN(C(=O)C5CC5)CC4)n3)c2)S1,,ClCCl,,CCN(CC)CC,,val
US20020173646A1,CN1CCNCC1.COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCCC(=O)O>>COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCCC(=O)N1CCN(C)CC1,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US05486617,CCCCC(=N)OC.COC(=O)CN.COC(OC)N(C)C.O=P(Cl)(Cl)Cl>>CCCCc1nc(C=O)c(Cl)[nH]1,,CO,Cc1ccccc1,Cl,[Na+].[OH-],val
US20160016908A1,CC(=O)Cl.COC(=O)c1cc2c(cc1OC)NC(C1CC1)C(C)C2NC(=O)OCc1ccccc1>>COC(=O)c1cc2c(cc1OC)N(C(C)=O)C(C1CC1)C(C)C2NC(=O)OCc1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20070078098A1,C1CCOC1.CC(=O)OC(CC[C@H]1C(=O)N(c2ccc(CCCNS(C)(=O)=O)cc2)[C@@H]1c1ccc(CCC2(OC(C)=O)COC(C)(C)OC2)cc1)c1ccc(F)cc1>>CCS(=O)(=O)NCCCc1ccc(N2C(=O)[C@H](CC[C@H](OC(C)=O)c3ccc(F)cc3)[C@H]2c2ccc(CCC(CO)(CO)OC(C)=O)cc2)cc1,,C1CCOC1,O,Cc1ccccc1,O=C(O)C(F)(F)F,val
US04252954,N.O=[N+]([O-])c1cc(I)c(I)cc1[N+](=O)[O-]>>Nc1cc(I)c(I)cc1[N+](=O)[O-],,CCO,,,,val
US04435419,CCC(=O)Cl.Cl.c1ccc(C23CNCC2C3)cc1>>CCC(=O)c1ccc(C23CNCC2C3)cc1.Cl,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20120108582A1,COC(=O)C1CN(Cc2ccccc2)CC1[C@H](C)CO[Si](C)(C)C(C)(C)C.O=C(Cl)OCc1ccccc1>>COC(=O)C1CN(C(=O)OCc2ccccc2)CC1[C@H](C)CO[Si](C)(C)C(C)(C)C,,ClCCl,,O,O=C([O-])O.[Na+],val
US20150209445A1,CC#N.CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1.CCN(C(C)C)C(C)C.CN(C)C=O.O=C(O)C(F)(F)F.O=C(Oc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1>>CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)N(C)CCN(C)C(=O)OC(C)(C)C)cc1,,CC#N,O,,,val
US20120208827A1,N#Cc1cccc2c1nc(-c1ccc(Br)cc1)n2C[C@@H]1CCN(C(=O)C2CC2)C1.OB(O)c1ccc2cc[nH]c2c1>>N#Cc1cccc2c1nc(-c1ccc(-c3ccc4cc[nH]c4c3)cc1)n2C[C@@H]1CCN(C(=O)C2CC2)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20090318436A1,Fc1cc(-c2ccc(Cl)cn2)cnc1F.NN>>NNc1ncc(-c2ccc(Cl)cn2)cc1F,,CC(C)O,O,,,val
US20080153852A1,CN(C)Cc1ccc(Br)o1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccccc1B(O)O>>CN(C)CC1=CC=C(c2ccccc2C=O)C1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US05374646,CCN(CC)CC.CCO.CCOC(=O)C(N)C(C)=O>>CCCCCc1nc(C(=O)OCC)c(C)[nH]1,,CCO,,Cl,,val
US20100240671A1,CC(C)(C)OC(=O)NC1CCC(C(=O)O)CC1.CNC>>CN(C)C(=O)C1CCC(NC(=O)OC(C)(C)C)CC1,,ClCCl,O,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20100317568A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.COC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)Nc1ccc([C@@H]2CC[C@@H](c3ccc(NC(=O)[C@@H]4CCCN4C(=O)OC(C)(C)C)cc3)N2c2ccc(C(C)(C)C)cc2)cc1)C(C)C>>COC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)Nc1ccc([C@@H]2CC[C@@H](c3ccc(NC(=O)[C@@H]4CCCN4C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC)cc3)N2c2ccc(C(C)(C)C)cc2)cc1)C(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070219230A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNc1cc2c(C)c(C)[nH]c2c(N2CCc3ccccc3C2)n1>>Cc1[nH]c2c(N3CCc4ccccc4C3)nc(CNC(=O)OC(C)(C)C)cc2c1C,,C1CCOC1,,CN(C)c1ccccn1,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2ncnn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2F)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2ncnn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20070106082A1,COCOc1ccc(OCOC)c(C2=C(C(=O)OC)CC(C)C2)c1>>COCOc1ccc(OCOC)c(C2CC(C)CC2C(=O)OC)c1,[Pd],CO,,,,val
US04479942,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCCCN2C(=O)c3ccccc3C2=O)cc1)C(=O)O>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCCCN)cc1)C(=O)O,,CCO,,NN,O,val
US04207073,CC(O)COC(C)CO.NC(N)=O.OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO>>CC(O)COC(C)CO.NC(=O)O,[Ni],,,,,val
US20050090505A1,CCN(CC)CC.CSC(=N)NC(=O)c1nc(Cl)c(N)nc1N.NCCCCc1ccc(OCC(=O)Nc2ccccc2)cc1>>N=C(N)N(CCCCc1ccc(OCC(=O)Nc2ccccc2)cc1)C(=O)c1nc(Cl)c(N)nc1N,,CCO,,I,,val
US20160243100A1,CC(C)(C)OC(=O)N1CCC(CS(=O)(=O)c2ccc(O)nc2)CC1.O=C(O)C(F)(F)S(=O)(=O)F>>CC(C)(C)OC(=O)N1CCC(CS(=O)(=O)c2ccc(OC(F)F)nc2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04264599,O=C1CCCc2[nH]c(-c3ccccc3)cc21>>Oc1cccc2[nH]c(-c3ccccc3)cc12,[Pd],c1ccc(Oc2ccccc2)cc1,,,,val
US20090156600A1,CCOC(=O)C(Cc1ccc(Cl)cc1)C(=O)CC.COC(=O)COc1ccc(F)c(N)c1>>CCc1[nH]c2c(F)ccc(OCC(=O)OC)c2c(=O)c1Cc1ccc(Cl)cc1,,O,,,,val
US20140343285A1,COC(=O)C(C)OCc1ccccc1>>CC(OCc1ccccc1)C(=O)O,,O,,[Na+].[OH-],,val
US06211376B1,COc1cccc2c(Cl)cc(C(F)(F)F)nc12>>COc1cccc2ccc(C(F)(F)F)nc12,[Pd],CCO,,CCN(CC)CC,,val
US04306065,CCCCCl.OC1CCCN(c2nc(-c3ccccc3)nc3ccccc23)C1>>CCCCOC1CCCN(c2nc(-c3ccccc3)nc3ccccc23)C1,,CN(C)C=O,,,,val
US20160221990A1,C=Cc1ccc(N2CCN(C(C)=O)CC2)cc1.Clc1cc(Br)cc(-c2ccncc2)c1>>CC(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(-c4ccncc4)c3)cc2)CC1,,CC#N,,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160083391A1,NC(=O)c1ncn(C2CCCC2)c1NC(=O)CCl>>O=c1[nH]c(CCl)nc2c1ncn2C1CCCC1,,O,,O=C([O-])O.[Na+],,val
US20150158863A1,COCCC(Oc1ccc(OC(F)(F)F)cc1)C(=O)OC>>COCCC(Oc1ccc(OC(F)(F)F)cc1)C(=O)O,,C1CCOC1,,Cl,[Na+].[OH-],val
US20060160864A1,CCOC(=O)CP(=O)(OCC)OCC.O=Cc1cc(Br)ccc1N1CCOCC1>>CCOC(=O)/C=C/c1cc(Br)ccc1N1CCOCC1,,Cc1ccccc1,,O,[H-].[Na+],val
US20120040987A1,Clc1ccc2nnc(Cl)n2n1.NC1CCOCC1>>Clc1nnc2ccc(NC3CCOCC3)nn12,,CN(C)C=O,,CCN(CC)CC,O,val
US20130079365A1,CCC(=O)Cl.NC1CCCc2c(Br)cncc21>>CCC(=O)NC1CCCc2c(Br)cncc21,,ClCCl,,CCN(CC)CC,O,val
US20140256734A1,CC(C)(C)OC(=O)N1CC[C@H](Oc2cccc(-c3n[nH]c(=O)[nH]3)n2)C1>>O=c1[nH]nc(-c2cccc(O[C@H]3CCNC3)n2)[nH]1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100064450A1,C1CCNCC1.C=O.COc1cc(C=O)ccc1O>>COc1cc(C=O)cc(CN2CCCCC2)c1O,,CCO,,,,val
US06350907B1,COc1cccc(-c2ccc(N)cc2C)c1.II>>COc1cccc(-c2ccc(I)cc2C)c1,,Cc1ccccc1,,CC(C)CCON=O,,val
US20150232463A1,CC1(C)CCNCC1.CCOC(=O)C(=O)c1c(C)nc(C)c(Br)c1Cl>>CCOC(=O)C(=O)c1c(C)nc(C)c(Br)c1N1CCC(C)(C)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20060094708A1,CC(C)Oc1ccc(C(=O)N[C@@H](Cc2ccc(-c3cn4cccc(Br)c4n3)cc2)CN2C(=O)c3ccccc3C2=O)cc1Cl>>CC(C)Oc1ccc(C(=O)N[C@H](CN)Cc2ccc(-c3cn4cccc(Br)c4n3)cc2)cc1Cl,,CCO,,NN,O,val
US20050256158A1,CC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2ccc(O)cc2)c2ccccc21.CCOC(=O)CCCBr>>CCOC(=O)CCCOc1ccc(C(=O)N2c3ccccc3[C@H](N(C(C)=O)c3ccc(Cl)cc3)C[C@@H]2C)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04894386,C1CCNC1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.O=C(O)/C=C/c1ccc2c(/C=C/C(=O)O)c[nH]c2c1>>O=C(/C=C/c1ccc2c(/C=C/C(=O)N3CCCC3)c[nH]c2c1)N1CCCC1,CN(C)c1ccncc1,CN(C)C=O,,Cl,Cl,val
US20090131431A1,CCn1nccc1N.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCn1nccc1NC(=O)C(F)(F)F,,ClCCl,,,,val
US20120245161A1,[N-]=[N+]=NCc1cc(Br)c(F)cc1F>>NCc1cc(Br)c(F)cc1F,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20030166639A1,CC(C)c1cc(-c2cccc(C(=O)CC(=O)OC(C)(C)C)c2)ccn1.Nc1cc(Cl)c(Cl)cc1N>>CC(C)c1cc(-c2cccc(C3=Nc4cc(Cl)c(Cl)cc4NC(=O)C3)c2)ccn1,,Cc1ccccc1C,,,,val
US20130116243A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3[nH]c(=O)c(N)cc3-c3ccccc3)cc2)CCC1.O=S(=O)(Cl)CCl>>CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)NS(=O)(=O)CO4)cc2)CCC1,,c1ccncc1,,O=C([O-])[O-].[K+].[K+],,val
US20100256113A1,CCCCCCS(=O)(=O)Cl.Cc1c(CN)[nH]c2ccccc2c1=O>>CCCCCCS(=O)(=O)NCc1[nH]c2ccccc2c(=O)c1C,,CN(C)C=O,c1ccncc1,Cl,Cl,val
US20160145232A1,NC1CCCCC1.O=C1OCC(C(=O)Cl)O1>>O=C1OCC(C(=O)NC2CCCCC2)O1,,C1CCOC1,,CCN(CC)CC,,val
US07235662B2,CC1(C)Nc2ccc3c(c2NC1=O)c(=O)oc1cccc(O)c13.CI>>COc1cccc2oc(=O)c3c4c(ccc3c12)NC(C)(C)C(=O)N4,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20090156557A1,CCS(=O)(=O)c1cccc(-c2cnc(Cl)c3[nH]c4ncc(C)cc4c23)c1.CN(C)CCCO>>CCS(=O)(=O)c1cccc(-c2cnc(OCCCN(C)C)c3[nH]c4ncc(C)cc4c23)c1,,C1COCCO1,,[H-].[Na+],,val
US20090131461A1,COc1cc2nccc(Oc3ccc(NC(=O)c4ccccc4)cc3)c2cc1OCC[C@H](NC(=O)OC(C)(C)C)C(=O)OC1CCCC1>>COc1cc2nccc(Oc3ccc(NC(=O)c4ccccc4)cc3)c2cc1OCC[C@H](N)C(=O)OC1CCCC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20050267200A1,CNC.CS(=O)(=O)OCC#Cc1ccc2c(-c3ccc(Cl)cc3)nsc2c1>>CN(C)CC#Cc1ccc2c(-c3ccc(Cl)cc3)nsc2c1,,CCO,,,,val
US20090143410A1,CCOC(=O)c1cnc(C(OCC)OCC)nc1C.NO>>CCOC(=O)c1cnc(C=NO)nc1C,,O,,CCO,Cl,val
US20130116235A1,COCc1cc(Nc2cc(-c3ccnc(N4CCc5c(cc6n5CCCC6)C4=O)c3C=O)cn(C)c2=O)nn1C>>COCc1cc(Nc2cc(-c3ccnc(N4CCc5c(cc6n5CCCC6)C4=O)c3CO)cn(C)c2=O)nn1C,,CO,,[BH4-].[Na+],,val
US20140155419A1,Cc1ccc(C(NC(=O)Cc2ccc(O)c(C)c2)c2ccccc2)c(C)c1.Cc1ncccc1CCl>>Cc1ccc(C(NC(=O)Cc2ccc(OCc3cccnc3C)c(C)c2)c2ccccc2)c(C)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110046135A1,CC(C)(C)OC(=O)N1CCOC[C@H]1COC(=O)N1CCN(c2ccc(F)cc2)CC1>>O=C(OC[C@@H]1COCCN1)N1CCN(c2ccc(F)cc2)CC1,,CCCCCCC,ClCCl,O=C(O)C(F)(F)F,,val
US05120843,COc1c(C)cc(CCCCO)cc1C>>Cc1cc(CCCCO)cc(C)c1O,,ClCCl,,BrB(Br)Br,,val
US20090137609A1,CCC(CC)(c1ccc(C#CC2(O)CCSCC2)c(C)c1)c1ccc(-c2cncc(CC(=O)O)c2)c(C)c1>>CCC(CC)(c1ccc(CCC2(O)CCSCC2)c(C)c1)c1ccc(-c2cncc(CC(=O)O)c2)c(C)c1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20140255381A1,CCOC(=O)CC(=O)CCl.NC(=S)c1ccc(F)cc1>>CCOC(=O)Cc1csc(-c2ccc(F)cc2)n1,,CCO,,,,val
US20100160303A1,COc1cccc(-c2ccc(C(N)=O)c3[nH]c4cc(C(=O)N5CCN(C)CC5)ccc4c23)c1F>>CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(-c4cccc(O)c4F)c23)CC1,,ClCCl,,BrB(Br)Br,CO,val
US20040152690A1,CC(C)(C)OC(=O)N1CCN(c2ncc(C(=O)O)cc2Cl)CC1.CI>>COC(=O)c1cnc(N2CCN(C(=O)OC(C)(C)C)CC2)c(Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05468882,NCC1CCc2ccccc2O1.O=C(Cl)C1CCCCCC1>>O=C(NCC1CCc2ccccc2O1)C1CCCCCC1,,c1ccncc1,,Cl,,val
US20160145252A1,CCOC(=O)c1cnc(-c2cccc(-c3cnn(C)c3)c2)nc1NC(C)C.NN>>CC(C)Nc1nc(-c2cccc(-c3cnn(C)c3)c2)ncc1C(=O)NN,,CCO,,O,,val
US20080081029A1,C=C(C)C(=O)NCCCCCCCCCCC(=O)[O-].C=CC(=O)NC(C)(C)CS(=O)(=O)O.[Na+]>>C=C(C)C(=O)NCCCCCCCCCCC(=O)[O-].C=CC(=O)NC(C)(C)CS(=O)(=O)O.[Na+],CC(C)(C#N)N=NC(C)(C)C#N,CCOCC,O,CO,[Na+].[OH-],val
US20150119380A1,Cc1cnc(N)c(C)n1.O=C(CBr)c1cc2ccc(CO)cc2oc1=O>>Br.Cc1cn2cc(-c3cc4ccc(CO)cc4oc3=O)nc2c(C)n1,,CC#N,,,,val
US06861539B1,CC(C)(C)OC(=O)N(Cc1ccccc1)[C@H](C=O)Cc1ccccc1.ClCI>>CC(C)(C)OC(=O)N(Cc1ccccc1)[C@@H](Cc1ccccc1)[C@H]1CO1,,C1CCOC1,,[Li]CCCC,,val
US20100317657A1,COC(=O)Cn1cc(-n2c(=O)n(C)c3cnc4ccc(Br)cc4c32)c(C)n1>>Cc1nn(CCO)cc1-n1c(=O)n(C)c2cnc3ccc(Br)cc3c21,,C1CCOC1,,CO,[BH4-].[Na+],val
US04230644,BrBr.c1ccc(OP(Oc2ccccc2)Oc2ccccc2)cc1>>BrBr.c1ccc(OP(Oc2ccccc2)Oc2ccccc2)cc1,,ClCCl,,,,val
US20120178752A1,COC(=O)c1cccc(O[C@H](C)C(=O)O)c1.N#Cc1ccc(N)cc1>>COC(=O)c1cccc(O[C@H](C)C(=O)Nc2ccc(C#N)cc2)c1,,O,c1ccncc1,O=P(Cl)(Cl)Cl,,val
US20070167506A1,Cc1cccc(C=O)c1C.[Li]CC>>CCC(O)c1cccc(C)c1C,,C1CCOC1,,,,val
US20090247746A1,CCOC(=O)[C@@H](N)CS.N#Cc1cc2cccc(NS(=O)(=O)c3cccs3)c2[nH]1>>CCOC(=O)C1CSC(c2cc3cccc(NS(=O)(=O)c4cccs4)c3[nH]2)=N1,,O,,CCO,Cl,val
US05332744,CC(C)(C)OC(=O)c1ccccc1-c1ccc(CBr)cc1.CCCCc1nc2cnccc2[nH]1.CCOC(C)=O.CO>>CCCCC1(CCCC)Nc2ccncc2N1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1,,CCOC(C)=O,CO,[H-].[Na+],,val
US04631272,CCCCN.O=C(O)C(=O)O.O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>CCCCNCC(=O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(O)C(=O)O,,C1COCCO1,CCO,,,val
US04199420,COCCO.O=C(c1ccccc1)c1ccc(CCl)cc1>>COCCOCc1ccc(C(=O)c2ccccc2)cc1,,O,,[K+].[OH-],,val
US20130005707A1,CC(C)(C)[Si](C)(C)OCCBr.Cc1n[nH]c2cc(Br)ccc12>>Cc1nn(CCO[Si](C)(C)C(C)(C)C)c2cc(Br)ccc12,,CN(C)C=O,,O,[H-].[Na+],val
US20140275179A1,CO.Cc1ccc(-c2snc(Cl)c2C#N)c(F)c1>>COc1nsc(-c2ccc(C)cc2F)c1C#N,,CO,,CO[Na],,val
US04317922,CCC12CCC(=O)C=C1c1c(cc(OC)c(Cl)c1Cl)C2>>CCC12CCC(=O)C=C1c1c(cc(O)c(Cl)c1Cl)C2,,O,,Cl,c1ccncc1,val
US20130116248A1,COc1ncc(Br)cc1NS(=O)(=O)c1ccccc1.Cn1c(=NC#N)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(B(O)O)ccc3ncc21>>COc1ncc(-c2ccc3ncc4c(c3c2)n(-c2ccc(C(C)(C)C#N)cc2)c(=NC#N)n4C)cc1NS(=O)(=O)c1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20120094964A1,FC(F)(F)c1cccnc1NCc1ccccc1.O=C(O)c1ccc(S(=O)(=O)Cl)cc1>>O=C(O)c1ccc(S(=O)(=O)N(Cc2ccccc2)c2ncccc2C(F)(F)F)cc1,CN(C)c1ccncc1,CO,c1ccncc1,,,val
US20120157439A1,COC(=O)Cl.Cc1ccc(C)n1-c1ccc(F)cc1Cl>>COC(=O)c1c(F)ccc(-n2c(C)ccc2C)c1Cl,,C1CCOC1,,[Li]CCCC,,val
US20080306125A1,O=C(O)c1cc2c(Br)cccc2s1>>Brc1cccc2sccc12,[Cu],CO,,c1ccc2ncccc2c1,,val
US20120142752A1,CC(C)(C)OC(=O)N[C@@H]1CN(Cc2ccccc2)C[C@H]1N.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CC(C)(C)OC(=O)N[C@@H]1CN(Cc2ccccc2)C[C@H]1NS(=O)(=O)c1ccc([N+](=O)[O-])cc1,,ClCCl,,CCN(CC)CC,,val
US20040157866A1,CC(=O)c1ccc(-c2ccccc2C(=O)Nc2ccc3c(c2)CCN3C(=O)Cc2ccccn2)cc1>>CC(O)c1ccc(-c2ccccc2C(=O)Nc2ccc3c(c2)CCN3C(=O)Cc2ccccn2)cc1,,C1CCOC1,CO,[BH4-].[Na+],,val
US20120238549A1,COc1ccc2c(c1)CCCC1=CC(=O)CCC12Cc1ccccc1>>O=C1C=C2CCCc3cc(O)ccc3C2(Cc2ccccc2)CC1,,ClCCl,,CS(=O)(=O)O,,val
US04215003,O=S(=O)(Cl)c1ccccc1.Oc1cccnc1>>O=S(=O)(Oc1cccnc1)c1ccccc1,,O,,[Na+].[OH-],,val
US05162318,CCOC(=O)N(CCN(C)C)c1cc(Br)cc(Br)c1N>>CN(C)CCn1c(=O)[nH]c2c(Br)cc(Br)cc21,,CCO,Cl,,,val
US20090054425A1,C=C[Sn](C=C)(C=C)C=C.Cc1ccc(S(=O)(=O)n2cc(I)c3c(Nc4ccc5cn[nH]c5c4)nc(Cl)nc32)cc1>>C=Cc1cn(S(=O)(=O)c2ccc(C)cc2)c2nc(Cl)nc(Nc3ccc4cn[nH]c4c3)c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US05412137,CCCCC=Cc1cccc(CCCCCOCc2ccccc2)c1>>CCCCCCc1cccc(CCCCCO)c1,[Pd],CO,,,,val
US20080015199A1,COc1ccc(C=O)cc1OC.C[Si](C)(C)C#N.N#Cc1ccc(N)cc1F>>COc1ccc(C(C#N)Nc2ccc(C#N)c(F)c2)cc1OC,,C1CCOC1,,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US20140187542A1,COc1ccc2ncc(=O)n(CC[C@H](O)COS(=O)(=O)c3ccc(C)cc3)c2n1>>COc1ccc2ncc(=O)n(CC[C@H]3CO3)c2n1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20100168418A1,CCOC=CC(=O)Nc1cc(OC)cc(C(=O)OC)c1>>COC(=O)c1cc(OC)cc2[nH]c(=O)ccc12,,O,,O=S(=O)(O)O,,val
US20100105744A1,CSCc1cc(F)cc2c(C(CCC#N)c3ccc(Cl)cc3F)c[nH]c12.O=C(OO)c1cccc(Cl)c1>>CS(=O)Cc1cc(F)cc2c(C(CCC#N)c3ccc(Cl)cc3F)c[nH]c12,,CO,,ClCCl,,val
US20090264403A1,CCCCOc1ccc2c(c1)CCN(c1ccc(N3CCC4(C3)OCCO4)cc1)C2=O>>CCCCOc1ccc2c(c1)CCN(c1ccc(N3CCC(=O)C3)cc1)C2=O,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05196306,CCOC(=O)Cc1c(C)c2ccc([C@@]3(C(C)=O)O[C@H](CO)[C@@](O)(C(C)=O)[C@@](O)(C(C)=O)[C@]3(O)C(C)=O)cc2oc1=O>>Cc1c(CC(=O)O)c(=O)oc2cc([C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)ccc12,,CO,,Cl,[K+].[OH-],val
US20110034464A1,CN(C)S(=O)(=O)c1cccc(CN)c1.N#CC(C(N)=O)C1OC(=O)C(Cl)=C1Cl>>CN(C)S(=O)(=O)c1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1.Cl,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US05008456,CCCC1CCC(=O)CC1.Cc1ccccc1.O.Oc1ccccc1>>CCCC1CCC(c2ccc(O)cc2)(c2ccc(O)cc2)CC1,,Cc1ccccc1,,Cl,,val
US20050049253A1,CC(C)(C)c1ccc(-n2ncc3cccc(N)c3c2=O)cc1.O=Cc1c[nH]c2ncccc12>>CC(C)(C)c1ccc(-n2ncc3cccc(NCc4c[nH]c5ncccc45)c3c2=O)cc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110275608A1,COC(=O)c1oc(=O)c2ccc(Br)cc2c1-c1ccccc1.NCC1CCN(Cc2cc(-c3ccccc3)no2)CC1>>COC(=O)C1(O)C(c2ccccc2)c2cc(Br)ccc2C(=O)N1CC1CCN(Cc2cc(-c3ccccc3)no2)CC1,,CO,,C1CCOC1,CCN(C(C)C)C(C)C,val
US20150087639A1,Cc1c[nH]c(=O)c(C)c1.Fc1cc(I)ccc1CN1CCOCC1>>Cc1cc(C)c(=O)n(-c2ccc(CN3CCOCC3)c(F)c2)c1,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US08846694B2,Clc1ncnc2nc[nH]c12.c1ccc2c(OCC3CCCN3)cccc2c1>>c1ccc2c(OC[C@H]3CCCN3c3ncnc4[nH]cnc34)cccc2c1,,CCCCO,,CCN(CC)CC,,val
US20160176817A1,CCOC(=O)C(=O)c1cc(C(=O)O)n(C)c1.Nc1ccc(F)c(F)c1>>CCOC(=O)C(=O)c1cc(C(=O)Nc2ccc(F)c(F)c2)n(C)c1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160122353A1,CCNC(=O)c1cn(-c2cccnc2)nc1N.CCOC(OCC)OCC>>CCn1cnc2nn(-c3cccnc3)cc2c1=O,,CC(=O)N(C)C,,Cc1ccc(S(=O)(=O)O)cc1,,val
US06043254,Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1>>Nc1ccc(-c2csc(N)n2)cc1,,CN(C)C=O,,,,val
US20040058939A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=c1[nH]ccc2cc3cccnc3n12>>Cc1ccc(S(=O)(=O)n2ccc3cc4cccnc4n3c2=O)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20020032208A1,O=S(Cl)Cl.OCc1ccnc(Cl)c1>>Cl.ClCc1ccnc(Cl)c1,,Cc1ccccc1,,,,val
US20040110748A1,N#Cc1ccc(S(=O)(=O)N2CCc3ccc(OCCCN4CCCCC4)cc3C2)cc1.OO>>NC(=O)c1ccc(S(=O)(=O)N2CCc3ccc(OCCCN4CCCCC4)cc3C2)cc1,,CO,O,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US06025375,C1=C(c2nc(-c3ccccc3)c(-c3ccccc3)o2)CCCC1.CS(C)=O.O=C1CCC(=O)N1Br>>OC1(c2nc(-c3ccccc3)c(-c3ccccc3)o2)CCCCC1Br,,CS(C)=O,,O,,val
US20110039831A1,CN(C=O)c1ccccc1.Cn1ncc2c(F)cc(F)cc21>>Cn1ncc2c(F)c(C=O)c(F)cc21,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20080051405A1,CC(C)N1CCC(Oc2cccc(CN)c2)CC1.CO.COC(=O)c1sc(-c2ccc(Cl)cc2)cc1/N=C/N(C)C>>CC(=O)O.CC(C)N1CCC(Oc2cccc(Cn3cnc4cc(-c5ccc(Cl)cc5)sc4c3=O)c2)CC1,,CO,,,,val
US20110039840A1,CC(=O)OC(C)=O.Oc1cccc(Br)c1>>CC(=O)c1ccc(Br)cc1O,,O,c1ccncc1,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20160158207A1,CC(C)(C)OC(=O)N1CCc2[nH]nc(Br)c2C1.CCOC(=O)C(C)Br>>CCOC(=O)C(C)n1nc(Br)c2c1CCN(C(=O)OC(C)(C)C)C2,,C1COCCO1,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110257179A1,COc1ccc(Cn2cc(-c3nc(Nc4ccc(F)cn4)sc3F)cn2)cc1>>Fc1ccc(Nc2nc(-c3cn[nH]c3)c(F)s2)nc1,,O=C(O)C(F)(F)F,,O=C([O-])[O-].[Na+].[Na+],,val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2cc(F)c(O[C@H]3C[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]3c3ccnn3C)cc2F)c(OC)c1>>COc1ccc(CN(c2ccncn2)S(=O)(=O)c2cc(F)c(O[C@H]3C[C@H](O)C[C@@H]3c3ccnn3C)cc2F)c(OC)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05047404,CCCOc1ccccc1C(=O)Cl.NC(=O)c1ncccc1N>>CCCOc1ccccc1C(=O)Nc1cccnc1C(N)=O,,CC#N,,CCN(CC)CC,,val
US20080161330A1,C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.O=C(O)c1ccccc1>>CCCC(C)C.CCOC(C)=O,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120283094A1,N#CCS(=O)(=O)CCC(F)(F)C(F)(F)F.O=S(=O)(OCCSC(F)(F)F)C(F)(F)F>>N#CC(CCSC(F)(F)F)S(=O)(=O)CCC(F)(F)C(F)(F)F,,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US06376664B1,CI.Cc1cccc2nc(-c3ccccc3[N+](=O)[O-])[nH]c12>>Cc1cccc2c1nc(-c1ccccc1[N+](=O)[O-])n2C,,C1CCOC1,,[H-].[Na+],,val
US20140080825A1,Nc1ncc(Cc2ccccc2Cl)o1.O=C(O)C1(c2ccc3c(c2)OCO3)CC1>>O=C(Nc1ncc(Cc2ccccc2Cl)o1)C1(c2ccc3c(c2)OCO3)CC1,,CC#N,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20020120007A1,CC(C)(C)c1ccc(C(=O)Nc2ccc([N+](=O)[O-])cc2C(=O)O)cc1>>CC(C)(C)c1ccc(-c2nc3ccc([N+](=O)[O-])cc3c(=O)o2)cc1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US04871748,CC(C)(CO)C1CCN(CC#Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1.CS(=O)(=O)Cl>>CC(C)(COS(C)(=O)=O)C1CCN(CC#Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20070238726A1,COc1ccc(CCl)cc1.Cc1cc([N+](=O)[O-])c(Cl)cc1Oc1ccnc2[nH]nc(I)c12>>COc1ccc(Cn2nc(I)c3c(Oc4cc(Cl)c([N+](=O)[O-])cc4C)ccnc32)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20080293782A1,O=C1CN(c2cc(C#Cc3ccc(F)cc3)ccc2OCc2ccccc2)S(=O)(=O)N1>>O=C1CN(c2cc(C#Cc3ccc(F)cc3)ccc2O)S(=O)(=O)N1,,ClCCl,,BrB(Br)Br,,val
US20110172237A1,Cc1cc(N)ncn1.O=C(Cl)CCl>>Cc1cc(NC(=O)CCl)ncn1,,ClCCCl,,,,val
US03956500,O=C(O)Cc1cccs1.O=[N+]([O-])CCOCCl>>CC(=O)SCOCC[N+](=O)[O-],,c1ccncc1,,C1CCOC1,,val
US20060094759A1,CCOS(=O)(=O)OCC.CN1CC[C@H](c2ccc(Cl)c(Cl)c2)[C@H](CO)C1>>CCOC[C@@H]1CN(C)CC[C@@H]1c1ccc(Cl)c(Cl)c1,,C1CCOC1,,O,[H-].[Na+],val
US20150353559A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)C(O)C1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N1CC[C@H]2NC(=O)O[C@H]2C1,,Cc1ccccc1,,CCN(CC)CC,,val
US20050176733A1,CC(C)(C)OC(=O)NC(Cc1ccc(Cl)cc1)C(=O)NCCCOc1ccc(Cl)cc1NC(=O)Nc1ccc(C#N)cn1>>N#Cc1ccc(NC(=O)Nc2cc(Cl)ccc2OCCCNC(=O)C(N)Cc2ccc(Cl)cc2)nc1,,CO,,C1COCCO1,Cl,val
US20050009804A1,COC(=O)c1sc(-c2ccccc2)cc1N(C(=O)C1CCC(C)CC1O)C1CCOCC1>>CC1CCC(C(=O)N(c2cc(-c3ccccc3)sc2C(=O)O)C2CCOCC2)C(O)C1,,C1COCCO1,,O,[Li+].[OH-],val
US20060041164A1,COC(=O)c1cccc(OCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(c2ccccc2)c2ccccc2)c1.Cl>>Cl.O=C(O)c1cccc(OCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(c2ccccc2)c2ccccc2)c1,,CO,O,[Na+].[OH-],,val
US20150376130A1,C#CC(C)(C)NC(=O)c1cccc(F)c1N.CCC=O>>C#CC(C)(C)NC(=O)c1cccc(F)c1NCCC,,ClCCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US20080070866A1,CCCCCOC(C)O.O=C(O)c1ccc(F)c(C(F)(F)F)c1>>CCCCCOCCOc1ccc(C(=O)O)cc1C(F)(F)F,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20140051692A1,C=CCBr.Cc1cc2c(cc1B1OC(C)(C)C(C)(C)O1)NCCO2>>C=CCN1CCOc2cc(C)c(B3OC(C)(C)C(C)(C)O3)cc21,,CN(C)C=O,O,N#N,O=C([O-])[O-].[K+].[K+],val
US20110224191A1,CC(c1c(Cl)ccc(F)c1Cl)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12.C[Si](C)(C)N=C=O>>CC(c1c(Cl)ccc(F)c1Cl)c1c[nH]c2ncc(-c3cnn(C4CCN(C(N)=O)CC4)c3)cc12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160096827A1,N#Cc1cc(Br)ccc1O[C@H]1CCNC[C@H]1F.O=C(O)CO>>N#Cc1cc(Br)ccc1O[C@H]1CCN(C(=O)CO)C[C@H]1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040110817A1,CC(C)(C)OC(=O)N[C@H](C(=O)N1CCC(O)C1)C1CCCCC1.CCN(CC)S(F)(F)F>>CC(C)(C)OC(=O)N[C@H](C(=O)N1CCC(F)C1)C1CCCCC1,,ClCCl,,,,val
US20100063038A1,C=C(C)OC(=O)Nc1cc(C(F)(F)F)ccn1.O=C(OO)c1cccc(Cl)c1>>C=C(C)OC(=O)Nc1cc(C(F)(F)F)cc[n+]1[O-],,ClC(Cl)Cl,,,,val
US20070249593A1,CC(C)(C)OC(=O)Nc1ccc(C(CN=[N+]=[N-])CN=[N+]=[N-])cc1>>CC(C)(C)OC(=O)Nc1ccc(C(CN)CN)cc1,[Pd],,,,,val
US20110039880A1,C=C[Mg]Br.O=[N+]([O-])c1cccnc1Br>>Brc1nccc2cc[nH]c12,,C1CCOC1,,,,val
US20060205802A1,COC(=O)Cl.Nc1ccc(F)c([N+](=O)[O-])c1>>COC(=O)Nc1ccc(F)c([N+](=O)[O-])c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140228376A1,CC(OCc1ccccc1)(c1nnc(-c2nc(C(F)(F)F)c(C(F)(F)F)nc2N)o1)C(F)(F)F>>CC(O)(c1nnc(-c2nc(C(F)(F)F)c(C(F)(F)F)nc2N)o1)C(F)(F)F,[Pd],CCO,,,,val
US20110196002A1,C#CC(=O)OCC.O=[N+]([O-])c1ccc(C(Cl)=NO)cc1>>CCOC(=O)c1cc(-c2ccc([N+](=O)[O-])cc2)no1,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,,val
US04404018,CC(Oc1cc(Oc2ccc(Br)cc2C#N)ccc1Br)C(=O)Cl.CCCCNCc1ccco1>>CCCCN(Cc1ccco1)C(=O)C(C)Oc1cc(Oc2ccc(Br)cc2C#N)ccc1Br,,ClCCl,,,,val
US04749704,COC1CCc2c1nc(S)[nH]c2=O>>COC1CCc2c1nc[nH]c2=O,[Ni],O,,N,,val
US20090029979A1,COC(=O)Cn1c2c(c3ccccc31)CCN(C(=O)OC(C)(C)C)C2.Cl>>COC(=O)Cn1c2c(c3ccccc31)CCNC2.Cl,,C1COCCO1,,,,val
US20080188467A1,COc1cc(NC(=O)OC(C)(C)C)c(Br)c(OC)c1C.O=C1CCC(=O)N1Br>>COc1cc(NC(=O)OC(C)(C)C)c(Br)c(OC)c1CBr,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20070155727A1,COC(=O)c1ccc(CN(C)CCCN(C)CC(=O)Nc2ccc(Oc3ccc(-c4ncco4)cc3)cc2)cc1>>CN(CCCN(C)Cc1ccc(C(=O)O)cc1)CC(=O)Nc1ccc(Oc2ccc(-c3ncco3)cc2)cc1,,C1CCOC1,,[Li+].[OH-],,val
US20120190649A1,CC(C)(C)[C@@H]1CC[C@@H](Oc2ccc3cc(C#N)ccc3c2)CC1>>CC(C)(C)[C@@H]1CC[C@@H](Oc2ccc3cc(CN)ccc3c2)CC1,[Ni],CO,,[NH4+].[OH-],,val
US20090246169A1,CCC12Cc3c([nH]c4ccc(OC)cc34)C(c3ccccc3)N1C(=O)N(CCN(C)C)C2=O>>CCC12Cc3c([nH]c4ccc(OC)cc34)C(c3ccccc3)N1C(=O)N(CCN)C2=O,,CO,,N,,val
US05089507,CC1(C)CCNC(=O)C(Cl)(Cl)C1>>CC1(C)CCNC(=O)C(Cl)C1,[Pd],CC(=O)O,,[H][H],,val
US20050187390A1,CC(=O)c1cc(F)ccc1-c1ccc(Cl)cc1.CCOC(=O)c1ccc2c(c1)nc(-c1ccc(N)c(C=O)c1)n2C1CCCCC1>>O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4cc(F)ccc4-c4ccc(Cl)cc4)ccc3c1)n2C1CCCCC1,,CCO,,Cl,[K+].[OH-],val
US20140303378A1,N#CC(C#N)CC(=O)c1ccccc1.Sc1cccc(Br)c1>>N#Cc1cc(-c2ccccc2)[nH]c1Sc1cccc(Br)c1,,CO,,CCN(CC)CC,,val
US20120277224A1,CCOC(=O)CC(=O)c1ccc2c(c1)OCCO2.Cc1n[nH]c(N)c1-c1ccccc1>>Cc1nn2c(=O)cc(-c3ccc4c(c3)OCCO4)[nH]c2c1-c1ccccc1,,CC(=O)O,,,,val
US20110237588A1,CCOC(=O)c1ccc(Cl)s1.CSc1nccc(C)n1>>CSc1nccc(CC(=O)c2ccc(Cl)s2)n1,,C1CCOC1,,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20070004772A1,FC(F)(F)CCCBr.O=c1[nH]nc2c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)ccn12>>O=c1n(CCCC(F)(F)F)nc2c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)ccn12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06602889B1,CS(=O)(=O)Cl.OCc1ccc2c(ccn2-c2ccc(F)cc2)c1>>Fc1ccc(-n2ccc3cc(CCl)ccc32)cc1,,ClCCl,,CCN(CC)CC,O,val
US20020147198A1,CC(C)(C)OC(=O)N1CCCC1COc1cc([N+](=O)[O-])cc(C(F)(F)F)c1>>O=[N+]([O-])c1cc(OCC2CCCN2)cc(C(F)(F)F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130096133A1,CCOC(=O)CN1CCN(Cc2ccc(C(C)C)cc2)CC1.NN>>CC(C)c1ccc(CN2CCN(CC(=O)NN)CC2)cc1,,CCO,,,,val
US20130296377A1,Cc1ccc(S(=O)(=O)n2ccc3c(C=O)c(C)cc(C)c32)cc1.O=C1CCC(=O)N1Br>>Cc1ccc(S(=O)(=O)n2cc(Br)c3c(C=O)c(C)cc(C)c32)cc1,,CN(C)C=O,O,,,val
US04315939,CCOC(=O)c1[nH]c(C)c(C)c1OCC(O)CCl.OC1(c2ccccc2)CCNCC1>>CCOC(=O)c1[nH]c(C)c(C)c1OCC(O)CN1CCC(O)(c2ccccc2)CC1.Cl,,C1COCCO1,,,,val
US20090048258A1,NC(N)=S.O=C(c1ccccc1)C(Br)Cc1ccccc1>>Nc1nc(-c2ccccc2)c(Cc2ccccc2)s1,,CCO,,,,val
US04888043,CCC(=O)C1=C(O)CC(c2c(C)cc(C)c(NS(C)(=O)=O)c2C)CC1=O.CCON>>CCON=C(CC)C1=C(O)CC(c2c(C)cc(C)c(NS(C)(=O)=O)c2C)CC1=O,,CCO,ClCCl,Cl,CC(=O)[O-].[Na+],val
US20150148313A1,CCS(=O)(=O)c1ccc([N+](=O)[O-])cc1CN(C)C(=O)OC(C)(C)C>>CCS(=O)(=O)c1ccc(N)cc1CN(C)C(=O)OC(C)(C)C,[Pd],CCOC(C)=O,CO,,,val
US05859044,CCOC(=O)c1cc2cc(CC3(C)OCCO3)ccc2n1Cc1ccc(N)cc1.O=S(=O)(Cl)CC(F)(F)F>>CCOC(=O)c1cc2cc(CC3(C)OCCO3)ccc2n1Cc1ccc(NS(=O)(=O)CC(F)(F)F)cc1,,ClCCl,O,CCN(CC)CC,,val
US20100173933A1,COc1ccc(-c2nc(COc3ccc(F)c(C(N)=O)c3F)sc2Br)cc1>>COc1ccc(-c2csc(COc3ccc(F)c(C(N)=O)c3F)n2)cc1,[Zn],CC(=O)O,,O,[Na+].[OH-],val
US06861418B2,COc1ccc(-c2cccc3c2CC(=O)N3)cc1.Cc1cc(C(=O)NCCn2ccnn2)c(C=O)[nH]1>>COc1ccc(-c2cccc3c2C(=Cc2[nH]c(C)cc2C(=O)O)C(=O)N3)cc1,C1CCNCC1,,,CCO,,val
US20120010182A1,CC(C)(C)OC(=O)N1CC(NN)C1.COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3ccc(-c4ccc(C(F)(F)F)cc4)cc3C(=O)/C=C/N(C)C)cc2F)c(OC)c1>>COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3ccc(-c4ccc(C(F)(F)F)cc4)cc3-c3ccnn3C3CN(C(=O)OC(C)(C)C)C3)cc2F)c(OC)c1,,CC(=O)O,CCO,O=C([O-])O.[Na+],,val
US20070067921A1,CCCCCCC#CCCCOc1cccc(C(=O)OC)c1>>CCCCCCC#CCCCOc1cccc(C(=O)O)c1,,CO,,[Na+].[OH-],,val
US20140018319A1,C1COCCN1.COc1ccc(CN(c2nc(Nc3cc(C#N)cc(N4CC[C@@H](N)[C@H](O[Si](C)(C)C(C)(C)C)C4)c3Cl)nn3c(C#N)cnc23)C2CC2)cc1.O=C(n1ccnc1)n1ccnc1>>COc1ccc(CN(c2nc(Nc3cc(C#N)cc(N4CC[C@@H](NC(=O)N5CCOCC5)[C@H](O[Si](C)(C)C(C)(C)C)C4)c3Cl)nn3c(C#N)cnc23)C2CC2)cc1,,C1CCOC1,,,,val
US20060074075A1,CC(C)(C)c1ccc([N+](=O)[O-])cc1O.CCOCCBr>>CCOCCOc1cc(N)ccc1C(C)(C)C,,CC#N,,,,val
US20020156081A1,CN1CCN([C@H]2CC[C@@H](n3nc(-c4ccc(N)cc4)c4c(N)ncnc43)CC2)CC1.Cc1cccc(N=C=O)c1>>Cc1cccc(NC(=O)Nc2ccc(-c3nn([C@@H]4CC[C@H](N5CCN(C)CC5)CC4)c4ncnc(N)c34)cc2)c1,,c1ccncc1,,,,val
US20160207939A1,NCC[C@H]1CCCCN1C(=O)OCc1ccccc1>>NCC[C@H]1CCCCN1,[Pd],CO,,,,val
US20040224960A1,CC(=O)Cl.CCc1cc(Br)ccc1O>>CCc1cc(Br)ccc1OC(C)=O,,ClCCl,,CCN(CC)CC,,val
US05723410,COC(=O)c1ccn(C)c1S(N)(=O)=O.COc1nc(C)nc(NC(=O)Oc2ccccc2)n1>>COC(=O)c1ccn(C)c1S(=O)(=O)NC(=O)NC1=NC(OC)=CN(C)N1,,CC#N,O,C1CCC2=NCCCN2CC1,Cl,val
US20110136800A1,COC(=O)c1cccc2c1[C@H]1CCCN[C@H]1CC2.O=C(O)c1ccc2[nH]cnc2c1>>COC(=O)c1cccc2c1[C@H]1CCCN(C(=O)c3ccc4[nH]cnc4c3)[C@H]1CC2,,CO,ClCCl,,,val
US20150322022A1,CC(=O)O.COc1ccc(-c2ccc(F)cc2)cc1OC>>CCCCCC.CCOC(C)=O,,O,,BrBr,,val
US20050227983A1,Clc1nc(Cl)nc(Nc2ccc(OCc3ccccc3)c(Cl)c2)n1.NC1CCCCCC1>>Clc1nc(Nc2ccc(OCc3ccccc3)c(Cl)c2)nc(NC2CCCCCC2)n1,,CC(C)=O,,O,[Na+].[OH-],val
US04845105,COCC(Cl)c1nc2cc(Cl)ccc2c(O)c1C(=O)Nc1nccs1>>COCC1OC(=Nc2nccs2)c2c1nc1cc(Cl)ccc1c2O,,C1CCOC1,,,,val
US04497953,COC(=O)[C@@H]1CC(N2CCCCC2)CN1>>COC(=O)[C@@H]1C[C@H](N2CCCCC2)CN1,[Pd],CO,O,[H][H],,val
US20090197767A1,COCCCc1nc(C(F)F)ccc1C(=O)OC>>COCCCc1nc(C(F)F)ccc1C(=O)O,,CO,O,,,val
US20090111789A1,CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)NC1CCN(C(=O)OC(C)(C)C)CC1.NC(=O)CI>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)NC1CCN(CC(N)=O)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20060089344A1,CN.NC(=O)COC(=O)NCCC1CCN(c2cccc(C(F)(F)F)c2)CC1.O=C1COC(=O)N1CCC1CCN(c2ccc3ccccc3n2)CC1>>CNC(=O)COC(=O)NCCC1CCN(c2ccc3ccccc3n2)CC1,,C1CCOC1,,,,val
US20070173501A1,CC1(C)O/C(=C2/C(=O)Nc3cc(F)c(F)cc32)C=C1c1ccc(C(=O)O)cc1.CNCC(O)CO>>CN(CC(O)CO)C(=O)c1ccc(C2=C/C(=C3\C(=O)Nc4cc(F)c(F)cc43)OC2(C)C)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110070317A1,CC(C)(C)OC(=O)N1CCC2CN(c3c(Br)cnc4[nH]cc(NC(=O)c5cccnc5)c34)CC21.Cl>>Cl.O=C(Nc1c[nH]c2ncc(Br)c(N3CC4CCNC4C3)c12)c1cccnc1,,CCOCC,ClCCl,O=C(O)C(F)(F)F,,val
US20140005168A1,CCc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCC[C@H](NC(=O)OC(C)(C)C)C3)n2)c1>>CCc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCC[C@H](N)C3)n2)c1,,C1COCCO1,CO,Cl,,val
US20060004017A1,N#CCc1ccc(Cl)cc1.O=[N+]([O-])c1ccc(OCc2ccccc2)c(C(F)(F)F)c1>>N#CCc1cc(OCc2ccccc2)c(C(F)(F)F)cc1[N+](=O)[O-],,CN(C)C=O,,Cl,CC(C)(C)[O-].[K+],val
US05714487,COC(=O)[C@H]1C[C@H]2C(=O)NCCN2C1>>OC[C@H]1C[C@H]2CNCCN2C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04420437,CC1(C)COP(OCc2ccccc2)OC1.ICc1ccccc1>>CC1(C)COP(=O)(Cc2ccccc2)OC1,,Cc1ccccc1C,,,,val
US20140323485A1,Nc1n[nH]c2ncccc12.Nc1nc(C(F)(F)F)c(Br)nc1C(=O)O>>Nc1nc(C(F)(F)F)c(Br)nc1C(=O)Nc1n[nH]c2ncccc12,,CN(C)C=O,O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040142820A1,C=C(C)OC.CNN.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(C(F)(F)F)nn1C,,COC(C)(C)C,,c1ccncc1,,val
US20120264738A1,CC1(C)CCC2(CC1)N[C@@H](C(=O)O)[C@H](c1cccc(Cl)c1F)C21C(=O)Nc2cc(Cl)ccc21.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.On1nnc2ccccc21>>CC1(C)CCC2(CC1)N[C@@H](C(=O)N[C@@H]1CC[C@@H](N3CC(O)C3)CC1)[C@H](c1cccc(Cl)c1F)[C@]21C(=O)Nc2cc(Cl)ccc21,,CN(C)C=O,CO,CCN(CC)CC,Cl,val
US20040242596A1,CC(C)(C)OC(=O)NCCCN.CCC(Br)c1nc2snc(C)c2c(=O)n1Cc1ccccc1>>CCC(NCCCNC(=O)OC(C)(C)C)c1nc2snc(C)c2c(=O)n1Cc1ccccc1,,CCO,,,,val
US20090170873A1,COC(=O)c1cc(-c2ccc(C)cc2F)cc(-c2ccnn2C(C)C)c1>>Cc1ccc(-c2cc(C(=O)O)cc(-c3ccnn3C(C)C)c2)c(F)c1,,C1CCOC1,O,[Li]O,,val
US20100290991A1,C=CCBr.CC(C)(C)OC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>C=CC[C@@H](C[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20090124612A1,C#CC(C)(C)O.COc1ccc2c(OCc3nnc4ccc(Cl)nn34)ccnc2c1>>COc1ccc2c(OCc3nnc4ccc(C#CC(C)(C)O)nn34)ccnc2c1,[Cu]I,,,CC#N,CCN(CC)CC,val
US20090209524A1,CCOC(=O)CC(C)=O.COc1cc(OCc2ccccc2)ccc1C=O>>CCOC(=O)C(=Cc1ccc(OCc2ccccc2)cc1OC)C(C)=O,,Cc1ccccc1,,C1CCNCC1,CC(=O)O,val
US20160244431A1,CC1(C)S[C@@H]2[C@H](N)C(=O)N2[C@H]1C(=O)O.ClCc1ccccn1.O=Cc1ccccn1>>CC1(C)S[C@H]2[C@H](N(Cc3ccccn3)Cc3ccccn3)C(=O)N2[C@H]1C(=O)O,,CCO,,Cl,[BH4-].[Na+],val
US20160158207A1,CN1CCN(c2nn(C3CCOCC3)c3c2CNCC3)c2cc(C#N)c(-c3cnn(C)c3)cc21.CNC(=O)n1ccnc1>>CNC(=O)N1CCc2c(c(N3CCN(C)c4cc(-c5cnn(C)c5)c(C#N)cc43)nn2C2CCOCC2)C1,,ClCCl,,CCN(CC)CC,,val
US04560811,C=C(CO)CCCCCCCCCCCCCC.CC(C)(C)OO>>CCCCCCCCCCCCCC[C@]1(CO)CO1,,Cc1ccccc1,ClCCl,CCCCCC,CCOC(C)=O,val
US20150087639A1,ICI.N#Cc1cccc(O)c1.O=[N+]([O-])c1ccc2cc[nH]c2c1>>N#Cc1cccc(OCn2ccc3ccc([N+](=O)[O-])cc32)c1,,CN(C)C=O,,[H-].[Na+],,val
US20040058903A1,Nc1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1.O=Cc1nccs1>>O=C(Nc1ccc(N=Cc2nccs2)cc1)c1ccccc1-c1ccc(C(F)(F)F)cc1,,C1CCOC1,,O=S(=O)([O-])[O-].[Mg+2],,val
US20090105231A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O.Nc1ccc(Br)cc1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1ccc(Br)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130196971A1,CC(C)(C)OC(=O)N1CC[C@@H](CNC(=O)c2ccc(Br)cc2)C1.C[Si](C)(C)N=[N+]=[N-]>>CC(C)(C)OC(=O)N1CC[C@@H](Cn2nnnc2-c2ccc(Br)cc2)C1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100210704A1,C#CCBr.CC(=O)Nc1cc(OC(F)(F)C(F)OC(F)(F)C(F)(F)C(F)(F)F)nn1-c1cc(SCC(F)(F)F)c(C)cc1F>>C#CCNc1cc(OC(F)(F)C(F)OC(F)(F)C(F)(F)C(F)(F)F)nn1-c1cc(SCC(F)(F)F)c(C)cc1F,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20090264462A1,COc1ccc(C[C@]2(C)C(=O)O[C@@H](c3ccccc3)N2C(=O)c2ccccc2)cc1>>COc1ccc(C[C@@](C)(N)C(=O)O)cc1,,Cl,,,,val
US04772600,Clc1ccc(-c2nc3cccnc3[nH]2)cc1.NC(=O)CCl>>NC(=O)Cn1c(-c2ccc(Cl)cc2)nc2ncccc21,,O,,[H-].[Na+],,val
US20150057268A1,CC(C)CC1(c2ccccc2)OC(=O)C2=C1CNCC2.O=C=NCc1ccccc1>>CC(C)CC1(c2ccccc2)OC(=O)C2=C1CN(C(=O)NCc1ccccc1)CC2,,ClCCl,,,,val
US05143918,CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OC)C3)C(C)CCC1=O)C(C)CC2OC.CCN(CC)S(F)(F)F>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(F)C(OC)C3)C(C)CCC1=O)C(C)CC2OC,,C1CCOC1,,CC#N,,val
US20090082379A1,CC(C)(C)c1ccc(N=C=O)cc1.COC(=O)C(C)(C)N>>CC1(C)NC(=O)N(c2ccc(C(C)(C)C)cc2)C1=O,,Cc1ccccc1,,CCN(CC)CC,Cl,val
US20050131001A1,CSc1cc(C)nc(SC)c1N.O=C(Cl)CCCBr>>CSc1cc(C)nc(SC)c1NC(=O)CCCBr,,O,,C1CCOC1,CCN(CC)CC,val
US20090143439A1,CN.COC(=O)c1cc(SC)cc(N)n1>>CNC(=O)c1cc(SC)cc(N)n1,,C1CCOC1,,,,val
US20100029664A1,COc1cccc(OC)c1C(=O)Cl.Clc1ccc2nc(NCC3CCNC3)oc2c1>>COc1cccc(OC)c1C(=O)N1CCC(CNc2nc3ccc(Cl)cc3o2)C1,,ClCCl,,CCN(CC)CC,Cl,val
US04426388,CCCCCCCC(=O)Cl.NS(=O)(=O)c1nc2cc(O)ccc2s1>>CCCCCCCC(=O)Oc1ccc2sc(S(N)(=O)=O)nc2c1,CN(C)c1ccncc1,c1ccncc1,,Cl,,val
US05013741,Nc1c2c(nc3ccccc13)CCCC2.O=Cc1c(Cl)cccc1Cl>>Clc1cccc(Cl)c1C=Nc1c2c(nc3ccccc13)CCCC2,,Cc1ccccc1,,C1COCCN1,,val
US06235730B1,CC(C)(C)[Si](C)(C)Cl.NC(O)CCc1ccccc1>>CC(C)(C)[Si](C)(C)OCCNCc1ccccc1,,O,,CN(C)C=O,c1c[nH]cn1,val
US20100239520A1,BrCCOc1ccccc1.Cc1nc(-c2ccn[nH]2)sc1C(=O)NCc1ccc(F)cc1>>Cc1nc(-c2ccn(CCOc3ccccc3)n2)sc1C(=O)NCc1ccc(F)cc1,,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20080004300A1,CC1(C)CNc2cc(N3C(=O)N(Cc4ccncc4)C(C)(C)C3=O)ccc21.O=S(=O)(Cl)c1ccccn1>>CC1(C)CN(S(=O)(=O)c2ccccn2)c2cc(N3C(=O)N(Cc4ccncc4)C(C)(C)C3=O)ccc21,,c1ccncc1,,Cl,,val
US20090275578A1,CS(=O)(=O)Cl.Cc1cc(-c2cncc(CO)c2)cc2c1C(=O)N(Cc1ccc(OC(F)(F)F)cc1)C2>>Cc1cc(-c2cncc(COS(C)(=O)=O)c2)cc2c1C(=O)N(Cc1ccc(OC(F)(F)F)cc1)C2,,ClCCl,,CCN(CC)CC,,val
US05716964,CCOC(=O)c1cn2cc(CO)ccc2n1.O=S(Cl)Cl>>CCOC(=O)c1cn2cc(CCl)ccc2n1,,ClC(Cl)Cl,,,,val
US20070021510A1,BrC(c1ccccc1)c1ccccc1.NC(N)=S.O=C(O)CCl>>OC(=S)CC(c1ccccc1)c1ccccc1,,O,,[Na+].[OH-],,val
US20100197655A1,Cc1n[nH]cc1B1OC(C)(C)C(C)(C)O1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cc1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1B1OC(C)(C)C(C)(C)O1,,CN(C)C=O,,CCN(CC)CC,,val
US04645765,COC(OC)c1cc(OC(C)=O)c2c(c1)N1CC3C(N3C(=O)OCc3ccccc3)C(OC(C)=O)(O1)C2COC(N)=O>>COC(OC)c1cc(OC(C)=O)c2c(c1)N1CC3NC3C(OC(C)=O)(O1)C2COC(N)=O,[Pd],CO,,,,val
US20110046110A1,CCOC(=O)c1cccc(NC(=O)OC(C)(C)C)n1>>CC(C)(C)OC(=O)Nc1cccc(CO)n1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080207654A1,CCCc1nc(C)n(-c2ccc(OC3CCCC3)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCc1nc(C)n(-c2ccc(OC3CCCC3)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20110098288A1,Fc1cnc(Cl)nc1Cl.Nc1ccccc1N>>Nc1ccccc1Nc1nc(Cl)ncc1F,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20100144782A1,CCN.O=C(O)c1ccc(Cl)nc1Cl>>CCNc1nc(Cl)ccc1C(=O)O,,O,,,,val
US05475000,COC(=O)Cl.O=c1c(-c2nnn[nH]2)cnc2ccccn12>>COC(=O)n1nnnc1-c1cnc2ccccn2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140038957A1,COCC1CN(C(=O)OC(C)(C)C)CCC1N.O=C(Cl)c1ccccc1>>COCC1CN(C(=O)OC(C)(C)C)CCC1NC(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20070043042A1,COc1ccc(Cn2c(=O)c(C#N)c(-c3cccc(F)c3)c3cc(OC)ccc32)c(OC)c1>>COc1ccc2[nH]c(=O)c(C#N)c(-c3cccc(F)c3)c2c1,,ClCCl,O=C(O)C(F)(F)F,CSC,,val
US20080249154A1,BrCc1ccccc1.O=Cc1c[nH]c(-c2ccccc2)n1>>O=Cc1cn(Cc2ccccc2)c(-c2ccccc2)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100311748A1,Brc1ncc[nH]1.COc1cccc(COc2ccc(C(=O)Nc3cc(B(O)O)ccc3C)cc2)c1>>COc1cccc(COc2ccc(C(=O)Nc3cc(-c4ncc[nH]4)ccc3C)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20110230458A1,CCC[Mg]Br.CON(C)C(=O)Cc1ccc(OCc2ccccc2)cc1>>CCCC(=O)Cc1ccc(OCc2ccccc2)cc1,,C1CCOC1,,,,val
US20110144194A1,COS(=O)(=O)OC.COc1ccc(-c2oc3cc(OC)c(I)c(O)c3c(=O)c2OC)cc1OC>>COc1ccc(-c2oc3cc(OC)c(I)c(OC)c3c(=O)c2OC)cc1OC,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20130116234A1,COC(=O)CC(=O)C1CC1.Nc1ccc(Cl)cc1C(=O)c1ccccc1>>COC(=O)c1c(C2CC2)nc2ccc(Cl)cc2c1-c1ccccc1,,CCO,,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US04634710,CCO.Cc1c[n+]([O-])c(C)cc1[N+](=O)[O-]>>CCOc1cc(C)[n+]([O-])cc1C,,CCOC(C)=O,,Cl,[Na],val
US20120083488A1,CC1(C)OC[C@H](COc2ccc3c(c2)C(=O)c2c([nH]c4cc(Br)ccc24)C3(C)C)O1.N#C[Cu]C#N>>CC1(C)c2ccc(OC[C@H](O)CO)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21,,O,,CC(=O)N(C)C,,val
US20120214762A1,C#C[Si](C)(C)C.O=C1CCCOC1>>C[Si](C)(C)C#CC1(O)CCCOC1,,C1CCOC1,,[Li]CCCC,,val
US20120071478A1,C[C@@H](NC(=O)OC(C)(C)C)c1cccc(N2CCN(C)CC2)c1>>C[C@@H](N)c1cccc(N2CCN(C)CC2)c1,,C1COCCO1,,Cl,,val
US20120165298A1,CC(C)(C)OC(=O)N1CCc2c(O)ncnc2C1.ClC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1CCc2c(Cl)ncnc2C1,,ClCCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100041646A1,CC(C)(C)[Si](C)(C)OCCNc1ccc(N2C[C@H](CNC(=O)c3ccc(Cl)s3)OC2=O)cc1>>O=C(NC[C@H]1CN(c2ccc(NCCO)cc2)C(=O)O1)c1ccc(Cl)s1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05654299,CNC(=O)c1ccccc1.O=C1CCN(C(=O)OCc2ccccc2)CC1>>O=C1OC2(CCN(C(=O)OCc3ccccc3)CC2)c2ccccc21,,C1CCOC1,,[Li]C(C)(C)C,,val
US20030166701A1,O=C(O)[C@H](O)[C@@H](O)C(=O)O.c1cnc2cc3c(cc2n1)C1CNCC3C1>>O=C(O)[C@H](O)[C@@H](O)C(=O)O.c1cnc2cc3c(cc2n1)C1CNCC3C1,,CO,,,,val
US20090203677A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)CCC(=O)NCc1ccc(F)c(-c2cccc(C=O)c2)c1.C[C@H]1CNCCN1C(=O)OC(C)(C)C>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)CCC(=O)NCc1ccc(F)c(-c2cccc(CN3CCN[C@@H](C)C3)c2)c1,,CS(C)=O,,CC(=O)O,,val
US05403816,COC(=O)c1nc(N)ccc1Oc1nc(OC)cc(OC)n1.S=C(Cl)Cl>>COC(=O)c1nc(N=C=S)ccc1Oc1nc(OC)cc(OC)n1,,ClCCl,O,,,val
US20090029903A1,CCCCc1ccc(C#Cc2ccc(CN(Cc3ccc(OCC(=O)OC)cc3)S(=O)(=O)CC)cc2)cc1>>CCCCc1ccc(C#Cc2ccc(CN(Cc3ccc(OCC(=O)O)cc3)S(=O)(=O)CC)cc2)cc1,,CCO,,Cl,[Na+].[OH-],val
US20090209555A1,CCCC[Sn](CCCC)(CCCC)c1cnnn1-c1ccc(C#N)cc1.CNC(=O)c1nc(Br)c(C)n(-c2cccc(C(F)(F)F)c2)c1=O>>CNC(=O)c1nc(-c2cnnn2-c2ccc(C#N)cc2)c(C)n(-c2cccc(C(F)(F)F)c2)c1=O,,COCCOC,,,,val
US05209868,CCC[C@H]1CC[C@H](C=C[C@@H]2CC[C@@H](C(F)(F)F)CC2)CC1>>CCC[C@H]1CC[C@H](CC[C@@H]2CC[C@@H](C(F)(F)F)CC2)CC1,[Pd],CO,,,,val
US04507498,CCCc1c(OCCCBr)ccc(C(C)=O)c1O.COC(=O)CBr>>CCCc1c(OCCCBr)ccc(C(C)=O)c1OCC(=O)OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US03945997,C=C(C=[N+]=[N-])c1ccccc1.C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F>>C=C(CO[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO)c1ccccc1,,CO,,,,val
US20100311966A1,CCO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1NC(=O)c1nc(Cl)c(CC)[nH]1.Cl>>CCO[C@@H]1CNCC[C@@H]1NC(=O)c1nc(Cl)c(CC)[nH]1.Cl,,CCO,,C1COCCO1,,val
US20140155381A1,COC(=O)Cc1ccc2oc(Br)cc2c1.O=Cc1ccncc1>>COC(=O)Cc1ccc2oc(C(O)c3ccncc3)cc2c1,,C1CCOC1,,CC(C)[Mg]Cl,[Cl-].[NH4+],val
US20120184537A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OC[C@@H]1CNc2ccccc2CN1>>CC(C)(C)OC(=O)N1Cc2ccccc2NC[C@H]1CO,,CCOC(C)=O,,CCN(CC)CC,O,val
US07799814B2,Cc1nc(Nc2cnccn2)sc1C(=O)CBr.N#CCC(N)=S>>Cc1nc(Nc2cnccn2)sc1-c1csc(CC#N)n1,,CCO,,Br,CCN(CC)CC,val
US20070191370A1,Nc1nc(Cl)cc(Cl)n1.OC(c1ccccc1C(F)(F)F)C(F)(F)F>>Nc1nc(Cl)cc(OC(c2ccccc2C(F)(F)F)C(F)(F)F)n1,,C1CCOC1,CCOC(C)=O,O,[H-].[Na+],val
US20080255122A1,CCCCN1C(=O)C(Cl)=C(c2cccc(Cl)c2)S1(=O)=O.Nc1ccc(N2CCOCC2)cc1>>CCCCN1C(=O)C(Nc2ccc(N3CCOCC3)cc2)=C(c2cccc(Cl)c2)S1(=O)=O,,CN(C)C=O,,,,val
US20060178418A1,COc1ccc(NS(=O)(=O)c2ccc(OC)c3sc4ccc(S(=O)(=O)Cl)cc4c23)cc1.C[NH2+]C>>COc1ccc(NS(=O)(=O)c2ccc(OC)c3sc4ccc(S(=O)(=O)N(C)C)cc4c23)cc1,,CC(C)=O,O,Cl,c1ccncc1,val
US20090181942A1,CC(C)I.COc1ccc(CN2C(=O)C(C(=O)O)CC(c3cccc(OC)c3OC)c3cc(Cl)ccc32)c(OC)c1>>COc1ccc(CN2C(=O)C(C(=O)OC(C)C)CC(c3cccc(OC)c3OC)c3cc(Cl)ccc32)c(OC)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130158003A1,CCOC(=O)C(C)=O.Nc1ccccc1N>>Cc1nc2ccccc2[nH]c1=O,,CCO,,,,val
US04066772,C=C(C)n1c(=O)n(CCCCl)c2ccccc21>>O=c1[nH]c2ccccc2n1CCCCl,,CCO,,Cl,,val
US20030092720A1,CC(C)c1csc(COc2ccn3c(=O)cc(O)nc3c2)n1.CN(C)C=O>>CC(C)c1csc(COc2ccn3c(=O)c(C=O)c(O)nc3c2)n1,,CN(C)C=O,,O=P(Cl)(Cl)Cl,O=C([O-])O.[Na+],val
US20110301167A1,CCOC(=O)c1nn(Cc2ccc(Br)nc2)c2ccccc2c1=O.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>CCOC(=O)c1nn(Cc2ccc(-c3cnn(C)c3)nc2)c2ccccc2c1=O,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],O=C([O-])O.[Na+],val
US20160221998A1,CCCN.FC(F)(F)c1ccnc(Cl)c1>>CCCNc1cc(C(F)(F)F)ccn1,,O,,CN1CCCC1=O,,val
US04963568,COc1ccc2c(c1OC)CC(C1CCCCC1)C=C2CN.Cl>>COc1ccc2c(c1OC)C[C@@H](C1CCCCC1)C[C@H]2CN.Cl,[Pd],CCO,,[H][H],,val
US20140343032A1,CS(=O)(=O)N1CC2COCC(C1)N2C(=O)OCc1ccccc1>>CS(=O)(=O)N1CC2COCC(C1)N2,[Pd],CO,,[H][H],,val
US05244889,CCOC(=O)C1CCCCCCCCCCC(C(=O)OCC)C(=O)N1>>O=C(O)C1CCCCCCCCCCC(C(=O)O)C(=O)N1,,CCO,,Cl,[Na+].[OH-],val
US04474778,O=C(CN1CCCC[C@H](NCC(=O)C(Cc2ccccc2)NC(=O)c2ccccc2)C1=O)OCc1ccccc1>>O=C(CN1CCCC[C@H](NCC(O)C(Cc2ccccc2)NC(=O)c2ccccc2)C1=O)OCc1ccccc1,,C1CCOC1,O,[BH4-].[Na+],,val
US20100173880A1,CCOC(=O)C(OS(C)(=O)=O)c1cccs1.Nc1ccccc1>>CCOC(=O)C(Nc1ccccc1)c1cccs1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20030096826A1,CC(C)(C)OC(=O)C[C@@H](C#N)NS(=O)(=O)c1ccc(C(N)=O)cc1OCCc1cccc2ncccc12>>N#C[C@H](CC(=O)O)NS(=O)(=O)c1ccc(C(N)=O)cc1OCCc1cccc2ncccc12,,ClCCl,O=C(O)C(F)(F)F,Cc1ccccc1,,val
US20040110807A1,CCOC(=O)C(Cc1ccc(O)c(F)c1)OCC.Cc1nc(-c2ccc(C(C)(C)C)cc2)sc1CO>>CCOC(=O)C(Cc1ccc(OCc2sc(-c3ccc(C(C)(C)C)cc3)nc2C)c(F)c1)OCC,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04197241,CC(C)NC(C)C.CCCI.CN1CCC(c2cccc(O)c2)C1=O.[Li]CCCC>>CC(C)[N-]C(C)C.CCCC1(c2cccc(O)c2)CCN(C)C1=O.[Li+],,C1CCOC1,O,,,val
US20070135497A1,COB(OC)OC.FC(F)(F)c1ccc(Cl)cc1Cl>>OB(O)c1c(Cl)ccc(C(F)(F)F)c1Cl,,C1CCOC1,,[Li]CCCC,,val
US05554706,COC(=O)c1ccc(O)cc1.OCCCCCCCCCCCBr>>COC(=O)c1ccc(OCCCCCCCCCCCO)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150045378A1,BrCc1ccccc1.COC(=O)c1cc(O)cc(OC)c1>>COC(=O)c1cc(OC)cc(OCc2ccccc2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100120762A1,COc1ccnc(-n2cnc(C)c2)c1N.O=N[O-]>>COc1ccnc2c1nnc1c(C)ncn12,,CC(=O)O,,[Na+].[OH-],,val
US20050065118A1,NCC(=O)c1cccc([N+](=O)[O-])c1.S=C=Nc1cccc(Br)c1>>O=C(CNC(=S)Nc1cccc(Br)c1)c1cccc([N+](=O)[O-])c1,,CC(C)=O,O,Cl,O=C([O-])O.[Na+],val
US20040063761A1,Cc1ccnc(N)c1[N+](=O)[O-].Fc1cc(Br)ccc1CBr>>Cc1ccnc(NCc2ccc(Br)cc2F)c1[N+](=O)[O-],,CN(C)C=O,,[H-].[Na+],,val
US20100144717A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H]1CCN(C(=O)OCc2ccccc2)C[C@H]1O>>CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)OCc2ccccc2)C[C@H]1O,,CCOC(C)=O,O,O=C([O-])O.[Na+],,val
US04371536,CCOC(=O)C1Cc2c([nH]c3cccc(C)c23)CN1>>CCOC(=O)c1cc2c(cn1)[nH]c1cccc(C)c12,,CCOC(C)=O,Cc1ccccc1,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20150111885A1,COc1nccc2cc(C)oc12.O=C1CCC(=O)N1Br>>COc1ncc(Br)c2cc(C)oc12,,CC#N,,,,val
US05047540,CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)c1ccccc1)CC(C)OC(=O)c1ccccc1>>CCCCCCCCCCCCCCCCCCNC(=O)OCC(CO)CC(C)OC(=O)c1ccccc1,,C1CCOC1,CO,CCOC(C)=O,[Na+].[OH-],val
US20100317624A1,CN(C)CCn1cc(C(=O)O)c(=O)c2cc(I)ccc21.CNC>>CN(C)CCn1cc(C(=O)N(C)C)c(=O)c2cc(I)ccc21,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140142105A1,N=C(NO)c1ccc(C(=O)O)c(F)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(O)c1ccc(-c2noc(C(F)(F)F)n2)cc1F,,C1CCOC1,,,,val
US20100004221A1,BrCC1CC1.COC(=O)c1cccc2[nH]ccc12>>COC(=O)c1cccc2c1ccn2CC1CC1,,CN(C)C=O,,Cl,[H-].[Na+],val
US04927822,CC(=O)SCCC(=O)N1N=C(C2CCCCC2)SCC1C(=O)OCc1ccccc1>>O=C(O)C1CSC(C2CCCCC2)=NN1C(=O)CCS,,CO,O,CC(=O)O,[K+].[OH-],val
US20100075948A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1.CC1(C)OC[C@H](CCN)O1>>CC(C)(C)CC1NC(C(=O)NCC[C@H](O)CO)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050182273A1,CC(OC(C)(C)CO)C1CCCCC1.CCC(=O)OC(=O)CC>>CCC(=O)OCC(C)(C)OC(C)C1CCCCC1,CN(C)c1ccncc1,CCOCC,,CCN(CC)CC,,val
US20010051631A1,CC(C)(C)OC(=O)NCc1cccc2nccn12.O=C(Cl)C(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1Cc2cccc3ncc(n23)C1=O,CN(C)c1ccncc1,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20030018024A1,O=C(Cl)c1ccc(-c2ccccc2)cc1.c1ccc2c(c1)CNc1ccccc1N2>>O=C(c1ccc(-c2ccccc2)cc1)N1Cc2ccccc2Nc2ccccc21,,CN(C)C=O,,ClCCl,O,val
US20040044052A1,Cc1ccc(C)n1-c1cc(F)cc(F)c1.O=C1CCSCC1>>Cc1ccc(C)n1-c1cc(F)c(C2(O)CCSCC2)c(F)c1,,C1CCOC1,,[Li]CCCC,,val
US20140364432A1,COc1ccnc(Cl)n1.Cc1nc(C(=O)N2CCC[C@@H](C)[C@H]2CN)c(-c2ccc(F)cc2)s1>>COc1ccnc(NC[C@@H]2[C@H](C)CCCN2C(=O)c2nc(C)sc2-c2ccc(F)cc2)n1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US05045228,CCCCCC[C@@H]1CC[C@H](O)C(=O)O1.O=C(O)c1ccc(OCc2ccccc2)cc1>>CCCCCCC1CCC(OC(=O)c2ccc(OCc3ccccc3)cc2)C(=O)O1,,c1ccccc1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120178715A1,N[C@H](C(=O)O)C1CCCC1>>N[C@H](CO)C1CCCC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050171109A1,COc1ccc2c(c1F)C(C)(C)CC(O)(C(F)(F)F)C2Nc1cccc2c1CNC2=O>>CC1(C)CC(O)(C(F)(F)F)C(Nc2cccc3c2CNC3=O)c2ccc(O)c(F)c21,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20130210838A1,COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)c(C)s1.FC(F)(F)N1C=Cc2c(Br)cnn2C1>>COC(=O)c1cc(-c2cnn3c2C=CN(C(F)(F)F)C3)c(C)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20040127426A1,CCC(NC(=O)C(N)CS(=O)(=O)Cc1ccccc1)C(O)c1nc2ccccc2o1.NCC(F)(F)F.S=C(n1ccnc1)n1ccnc1>>CCC(NC(=O)C(CS(=O)(=O)Cc1ccccc1)NC(=S)NCC(F)(F)F)C(O)c1nc2ccccc2o1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20100056576A1,Nc1cc(F)c(Br)nc1C(=O)O.Nc1cnccc1C1CCCC(N2C(=O)c3ccccc3C2=O)C1>>Nc1cc(F)c(Br)nc1C(=O)Nc1cnccc1[C@@H]1CCC[C@H](N2C(=O)c3ccccc3C2=O)C1,,CCOC(C)=O,,,,val
US04954503,N#CN1CCN(c2n[nH]c3ccc(Cl)cc23)CC1>>Clc1ccc2[nH]nc(N3CCNCC3)c2c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070021426A1,CS(=O)(=O)Cl.OCCCC#Cc1cccc2ccccc12>>CS(=O)(=O)OCCCC#Cc1cccc2ccccc12,,ClCCl,,CCN(CC)CC,O,val
US20150344473A1,C[C@@H](O)C(=O)O.N#Cc1cc(-c2ncnc3[nH]c(-c4ccc(N5CCOCC5)cc4)nc23)ccc1O[C@@H]1CCNC1>>C[C@@H](O)C(=O)N1CC[C@@H](Oc2ccc(-c3ncnc4[nH]c(-c5ccc(N6CCOCC6)cc5)nc34)cc2C#N)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090093454A1,Fc1cccc2nc(CCl)cn12.c1cnc2c(c1)CCC[C@H]1CCCN[C@H]21>>Fc1cccc2nc(CN3CCC[C@@H]4CCCc5cccnc5[C@H]43)cn12,,CC#N,,[I-].[K+],,val
US20030187027A1,CO.COC(OC)OC.O=Cc1ccc(-c2ccccc2CNC(=O)OCC2c3ccccc3-c3ccccc32)cc1>>COC(OC)c1ccc(-c2ccccc2CNC(=O)OCC2c3ccccc3-c3ccccc32)cc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20130150343A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](OCC(=O)N3CCOCC3)c3ccccc32)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](OCCN3CCOCC3)c3ccccc32)cc1,,C1CCOC1,O,B,,val
US20100105747A1,CCOC(=O)[C@H]1CC[C@H](O)[C@@H](c2ccccc2C)[C@@H]1C(=O)OCC>>Cc1ccccc1[C@@H]1[C@@H](O)CC[C@H](CO)[C@H]1CO,,C1CCOC1,,[BH4-].[Li+],,val
US05545669,COC(=O)c1ccccc1Oc1cc(Cl)c(Cl)cc1N(S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C(O)c1ccccc1Oc1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CO,,[Na+].[OH-],,val
US20150099888A1,COc1cc(Nc2ncccc2C=O)cc(OC)c1OC.COc1ccc(C(C)=O)cc1OC>>COc1ccc(C(=O)/C=C/c2cccnc2Nc2cc(OC)c(OC)c(OC)c2)cc1OC,,CO,,Cl,,val
US20100249119A1,CN1CCNCC1.Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Oc1ccc2nc(NC(=O)CCl)sc2n1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Oc1ccc2nc(NC(=O)CN3CCN(C)CC3)sc2n1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US05608069,CCC=C(C=NO)c1ccccc1.CCOC(=O)[C@@H]1CCCN(CCBr)C1>>CCC=C(C=NOCCN1CCC[C@@H](C(=O)OCC)C1)c1ccccc1,,CC(C)=O,,Br,O=C([O-])[O-].[K+].[K+],val
US20120202802A1,O=C(O)CC1(O)CC[C@@H](C(=O)OCc2ccccc2)C1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>O=C1NCC2(CC[C@@H](C(=O)OCc3ccccc3)C2)O1,,C1CCOC1,Cc1ccccc1,CCN(CC)CC,,val
US20040102492A1,COc1c(NC(=O)c2ccc(C)c(-n3cc(C(=O)NCC4CCCN(C(=O)OC(C)(C)C)C4)nn3)c2)cc(C(C)(C)C)cc1NS(C)(=O)=O>>COc1c(NC(=O)c2ccc(C)c(-n3cc(C(=O)NCC4CCCNC4)nn3)c2)cc(C(C)(C)C)cc1NS(C)(=O)=O,CO,C1COCCO1,ClCCl,Cl,,val
US20100216694A1,Cc1c(I)ccc(F)c1CO.O=S(Cl)Cl>>Cc1c(I)ccc(F)c1CCl,,c1ccccc1,,,,val
US20130317066A1,CCC(=O)Nc1cc(Oc2cc(F)c(N)cc2F)ccn1.CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)O>>CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1cc(F)c(Oc2ccnc(NC(=O)CC)c2)cc1F,,ClCCl,O,O=S(Cl)Cl,c1ccncc1,val
US05102882,O=C(Cl)CCl.O=C1CCC(C(=O)N2CCNCC2)N1>>O=C1CCC(C(=O)N2CCN(C(=O)CCl)CC2)N1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20030216373A1,O=C1O[C@@H](CO)CN1c1ccc(C2=CCN(Cc3ccccc3)CC2)c(F)c1.O=c1[nH]cco1>>O=C1O[C@@H](Cn2ccoc2=O)CN1c1ccc(C2=CCN(Cc3ccccc3)CC2)c(F)c1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20040039064A1,CC(C)(C)OC(=O)NC[C@H](O)[C@H]1COC(C)(C)O1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)NC[C@H](OS(C)(=O)=O)[C@H]1COC(C)(C)O1,,ClCCl,,CCN(CC)CC,,val
US20160198708A1,CCOC(=O)CC#N.Clc1cc(Br)cnc1Cl>>CCOC(=O)C(C#N)c1ncc(Br)cc1Cl,,CN(C)C=O,O,[H-].[Na+],,val
US20040259912A1,COC(=O)c1cc([N+](=O)[O-])ccc1OC(c1ccc(F)cc1)c1ccc(C(F)(F)F)cc1>>COC(=O)c1cc(N)ccc1OC(c1ccc(F)cc1)c1ccc(C(F)(F)F)cc1,[Fe],CCO,O,[Ca+2].[Cl-].[Cl-],,val
US20110280804A1,O=C(O)c1ccccc1.O=c1[nH]c2ccc(CCCCl)cc2s1>>O=C(OCCCc1ccc2[nH]c(=O)sc2c1)c1ccccc1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20090047221A1,COc1cc(CC(C)=O)cc(OC)c1OC>>COc1cc(CC(C)O)cc(OC)c1OC,,CO,,[BH4-].[Na+],,val
US20100056521A1,CCOC(=O)c1ccc(-n2cc(C#N)c3ccc(O)cc32)cc1OCOC.O=C(NCCBr)OCc1ccccc1>>CCOC(=O)c1ccc(-n2cc(C#N)c3ccc(OCCNC(=O)OCc4ccccc4)cc32)cc1OCOC,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120094982A1,COc1ccc(CN2C(=O)C(Cc3ccccc3Cl)N=C(c3cnc4[nH]c(=O)n(C(=O)OC(C)(C)C)c4c3)c3cc(Cl)ccc32)cc1>>COc1ccc(CN2C(=O)C(Cc3ccccc3Cl)N=C(c3cnc4[nH]c(=O)[nH]c4c3)c3cc(Cl)ccc32)cc1,,C1COCCO1,Cl,,,val
US20130203703A1,CN(C(=O)c1c(O)c2ccccc2n(C)c1=O)c1ccccc1.Nc1ccc(F)cc1>>Cn1c(=O)c(C(=O)Nc2ccc(F)cc2)c(O)c2ccccc21,,Cc1ccccc1,,CCCCCCC,,val
US20090270417A1,COCCCOc1cc(C[C@@H](C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN(C(=O)[C@@H](O)C(C)C)C2CC2)C(C)C)ccc1OC>>COCCCOc1cc(C[C@@H](C[C@@H]2CNC[C@H]2CN(C(=O)[C@@H](O)C(C)C)C2CC2)C(C)C)ccc1OC,,Cl,,C1COCCO1,,val
US05420275,CCOC(=O)c1cc(-c2ccccc2)[nH]c(=O)c1C(=O)OCC.O=[N+]([O-])O>>CCOC(=O)c1c([N+](=O)[O-])c(-c2ccccc2)[nH]c(=O)c1C(=O)OCC,,CC(=O)OC(C)=O,,O,,val
US20050054631A1,O=Cc1c(Cl)[nH]c2ncccc12.OB(O)c1ccccc1>>O=Cc1c(Cl)n(-c2ccccc2)c2ncccc12,,ClCCl,,CCN(CC)CC,c1ccncc1,val
US04104472,COCc1nc[nH]c1C.Cl.Cl.NCCS>>Cc1[nH]cnc1CSCCN.Cl.Cl,,CC(=O)O,,,,val
US05969138,COCCN1CCN(C[C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>COCCN1CCN(C[C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1.O=C(O)[C@H](O)[C@@H](O)C(=O)O,,CCO,CCOC(C)=O,,,val
US20080269208A1,CCOC(=O)C1CN(C(=O)OC(C)(C)C)CCN1CCNC(=O)OC(C)(C)C>>O=C1NCCN2CCNCC12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090176847A1,Cl.N#CC1CCCN1C(=O)CNC1CC2CC(=O)CC2C1>>Cl.N#CC1CCCN1C(=O)CNC1CC2CC(=O)CC2C1,,CCOCC,,,,val
US20160095858A1,CC(C)(C)OC(=O)CNC(C)(C)c1ccccc1Br.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)CN(C(=O)OCc1ccccc1)C(C)(C)c1ccccc1Br,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06271225B1,Cc1ccc(NC(=O)c2c(Br)sc3c2CCCC3)c(O)c1>>Cc1ccc2c(c1)Oc1sc3c(c1C(=O)N2)CCCC3,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150291595A1,COc1cccc(CNC(=O)c2c(N)ncnc2N[C@@H](C)c2nn3ccc(C)c3c(=O)n2-c2ccccc2)c1>>Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3C(=O)NCc3cccc(O)c3)n(-c3ccccc3)c(=O)c12,,ClCCl,,BrB(Br)Br,,val
US20140128392A1,COC(=O)c1ccc2nc(-c3ccccc3)c(-c3cccc(C(=O)O)c3)nc2c1>>O=C(O)c1cccc(-c2nc3cc(C(=O)O)ccc3nc2-c2ccccc2)c1,,CO,O,[Na+].[OH-],,val
US20110224188A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1(c2ccc(I)cn2)CC1>>CC(C)(C)OC(=O)NC1(c2ccc(I)cn2)CC1,,C1CCOC1,O,CCN(CC)CC,,val
US20160200674A1,Cc1cccc(-c2ccc(N(CC(C)C)CC(C)C)c(N)c2)c1C(=O)O.O=C=Nc1ccc(OC(F)(F)F)cc1>>Cc1cccc(-c2ccc(N(CC(C)C)CC(C)C)c(NC(=O)Nc3ccc(OC(F)(F)F)cc3)c2)c1C(=O)O,,CN(C)C=O,,,,val
US06004724,CS(=O)(=O)Cl.Cc1ccc(C(C#N)=C2C=CC(=NO)C=C2)cc1C>>Cc1ccc(C(C#N)=C2C=CC(=NOS(C)(=O)=O)C=C2)cc1C,,C1CCOC1,,CCN(CC)CC,O,val
US20070032502A1,CC[C@@H](C)[C@H](Nc1nc(CCl)nc2ccccc12)C(N)=O.Clc1ccc(C(c2ccc(Cl)cc2)N2CCNCC2)cc1>>CC[C@@H](C)[C@H](Nc1nc(CN2CCN(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)CC2)nc2ccccc12)C(N)=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110105542A1,BrCc1ccccc1.CCc1cccc(CC)c1NC(=O)c1nn(C)c2c1CCc1cnc(NC3CCNCC3)nc1-2>>CCc1cccc(CC)c1NC(=O)c1nn(C)c2c1CCc1cnc(NC3CCN(Cc4ccccc4)CC3)nc1-2,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20100273779A1,COc1ccc(-c2cc(=O)n(C)nc2C)cc1>>Cc1nn(C)c(=O)cc1-c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,,val
US20050165003A1,CS(=O)(=O)Cl.OCCc1ccccn1>>CS(=O)(=O)CCc1ccccn1,,ClCCl,,CCN(CC)CC,O,val
US04678785,CCOC(=S)NN.O=C1CCc2cc(C(=O)CCl)ccc2N1>>O=C1CCc2cc(C3=NNC(=O)SC3)ccc2N1,,CC#N,,,,val
US05530119,C1CNCCN1.O=[N+]([O-])c1ccc(CBr)cc1>>Br.O=[N+]([O-])c1ccc(CN2CCNCC2)cc1,,CCO,,,,val
US06136823,CN.Cc1cc(F)c(N)cc1-n1cc(C(=O)O)c(=O)c2cc(F)c(F)c(Cl)c21>>CNc1c(F)cc2c(=O)c(C(=O)O)cn(-c3cc(N)c(F)cc3C)c2c1Cl,,c1ccncc1,,,,val
US20090281062A1,CC(=O)OCC(COC(C)=O)N(C)CC(=O)OC(C)(C)C>>CC(=O)OCC(COC(C)=O)N(C)CC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US07115608B2,Cc1cc(C)cc(Oc2c(CCl)c(C)[nH]c(=O)c2I)c1.NC(N)=S>>Cc1cc(C)cc(Oc2c(CS)c(C)[nH]c(=O)c2I)c1,,CS(C)=O,,Cl,[Na+].[OH-],val
US20160016946A1,CCCCOC(=O)Cl.NS(=O)(=O)c1ccc(OC(F)(F)F)cc1-c1ccc(Cn2ccnc2)cn1>>CCCCOC(=O)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1-c1ccc(Cn2ccnc2)cn1,CN(C)c1ccncc1,c1ccncc1,,,,val
US04734429,CC(=O)C1C(=O)CCCC1=O.CNN>>Cc1nn(C)c2c1C(=O)CCC2,,CO,,,,val
US20070213333A1,CCOC(=O)CCc1ccc(OCC2CCCC2)nc1.O=C1CCC(=O)N1Br>>CCOC(=O)CCc1cnc(OCC2CCCC2)c(Br)c1,,CC#N,,BrBr,,val
US20140163024A1,CC(C)CN(c1ccccc1C(F)(F)F)S(=O)(=O)c1ccc(N)cc1.CS(=O)(=O)N1CCC(C(=O)Cl)CC1>>CC(C)CN(c1ccccc1C(F)(F)F)S(=O)(=O)c1ccc(NC(=O)C2CCN(S(C)(=O)=O)CC2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090306082A1,COC(Cl)Cl.COc1cccc2cc(C)oc12>>COc1ccc(C=O)c2cc(C)oc12,,ClCCl,,,,val
US20110124665A1,CC(C)(C)OC(=O)NN1CCCC(Oc2ncnc3oc(-c4ccccc4)c(Br)c23)C1>>Brc1c(-c2ccccc2)oc2ncnc(OC3CCCNC3)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US05741926,Nc1ccccc1F.O=C(CBr)OCc1ccccc1>>O=C(CNc1ccccc1F)OCc1ccccc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20070105891A1,CC(=O)Cl.Nc1cnccc1O>>CC(=O)Nc1cnccc1O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100216836A1,OCCCBr.Oc1cccc([C@H]2CCCN(C[C@H]3COc4ccccc4O3)C2)c1>>OCCCOc1cccc([C@H]2CCCN(C[C@H]3COc4ccccc4O3)C2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04843100,Nc1ccc(S(=O)C(F)(F)C(F)F)cc1F.O=C=NC(=O)c1c(F)cccc1Cl>>O=C(NC(=O)c1c(F)cccc1Cl)Nc1ccc(S(=O)C(F)(F)C(F)F)cc1F,,Cc1ccccc1,,,,val
US20090286778A1,CC(C)(C)OC(=O)Nc1cccc(NC(=O)Cc2cccc(N)c2)c1.Clc1ncc(Cl)c(Cl)n1>>CC(C)(C)OC(=O)Nc1cccc(NC(=O)Cc2cccc(Nc3nc(Cl)ncc3Cl)c2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060046978A1,COC(=O)C(Cc1ccc(NC(=O)CCC(NC(=O)OC(C)(C)C)C(=O)N2CCCC2C#N)cc1)NC(=O)C(CSC(C)=O)Cc1ccccc1>>COC(=O)C(Cc1ccc(NC(=O)CCC(N)C(=O)N2CCCC2C#N)cc1)NC(=O)C(CSC(C)=O)Cc1ccccc1,,O=C(O)C(F)(F)F,,O,,val
US06627629B2,CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)OCc2ccccc2)[C@@H](C(=O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)C1>>CC(C)(C)OC(=O)N1CC[C@@H](N)[C@@H](C(=O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)C1,[Pd],CO,,,,val
US20040138277A1,CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccc(C)cc1.Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccc(-c4ccccc4)cc3)oc2C)cc1>>Cc1ccc(OC(C)(Cc2ccc(OCCc3nc(-c4ccc(-c5ccccc5)cc4)oc3C)cc2)C(=O)O)cc1,,CCO,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US09248117B2,CC(C)(CCS(=O)(=O)CCOCCOCCOC(C)(C)C)NC(=O)OCc1ccccc1>>CC(C)(N)CCS(=O)(=O)CCOCCOCCOC(C)(C)C,[Pd],CO,,,,val
US20040220222A1,CC(C)(C)OC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N1CCc2ccccc2C1>>NC(Cc1c[nH]c2ccccc12)C(=O)N1CCc2ccccc2C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080280869A1,COc1ccc(NN)cc1.O=CC(C=O)c1cccc(C(=O)O)n1>>COc1ccc(-n2cc(-c3cccc(C(=O)O)n3)cn2)cc1,,CC(=O)O,,Cl,CC(=O)[O-].[Na+],val
US20100160369A1,N.O=C(Cl)c1ccc(-c2noc(-c3cn4cc(C(F)(F)F)cc(Cl)c4n3)n2)c(Cl)c1>>NC(=O)c1ccc(-c2noc(-c3cn4cc(C(F)(F)F)cc(Cl)c4n3)n2)c(Cl)c1,,CCOC(C)=O,,,,val
US20050239841A1,COc1ccc([C@@]23CC[C@@H](N)C[C@@H]2N(C)CC3)cc1OC.O=C(O)c1ccnc2ccccc12.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COc1ccc([C@@]23CC[C@@H](NC(=O)Nc4ccnc5ccccc45)C[C@@H]2N(C)CC3)cc1OC,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US20070099911A1,BrBr.NCCc1c[nH]c2ccc3c(=O)[nH]ccc3c12>>NCCc1c(Br)[nH]c2ccc3c(=O)[nH]ccc3c12,,CN(C)C=O,,,,val
US20040019016A1,CCCCCCCCC(Br)CN(c1ccc(C#N)cc1)n1cnnc1.Oc1ccc(S)cc1>>N#Cc1ccc(N(CCCCCCCCCCSc2ccc(O)cc2)n2cnnc2)cc1,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20140343029A1,Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCNCC1.Nc1ncnc(Cl)c1Br>>Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2Br)CC1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US04219649,CCc1c(C)nc2ccc(Cl)cn2c1=O.Cl>>CCc1c(C)nc2ccc(Cl)cn2c1=O.Cl,,CCO,,,,val
US20090197864A1,C[C@H](OS(C)(=O)=O)c1c(Cl)ccc(F)c1Cl.O=[N+]([O-])c1ncc2ccoc2c1O>>C[C@@H](Oc1c([N+](=O)[O-])ncc2ccoc12)c1c(Cl)ccc(F)c1Cl,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US05321037,Cl.OC(COc1cc(-c2ccccc2)on1)CN1CCOCC1>>Cl.OC(COc1cc(-c2ccccc2)on1)CN1CCOCC1,,C1COCCO1,CCOC(C)=O,,,val
US04777181,CC(=O)N1CCNC1=O.NN1Cc2cccc(F)c2C1>>Fc1cccc2c1CN(NC1=NCCN1)C2,,O=P(Cl)(Cl)Cl,,Cl,,val
US05747000,COCCBr.O=C(O)CN1CCNCCN(CC(=O)O)CCN(CC(=O)O)CC1>>COCCN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05932599,CN.CNc1nc(Cl)cc(NS(=O)(=O)c2ccc(F)cc2)n1>>CNc1cc(NS(=O)(=O)c2ccc(F)cc2)nc(NC)n1,,CCO,,CCN(CC)CC,Cl,val
US20140371199A1,Cc1nnc(C2(C)CCNCC2)o1.N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)O)cc4)cn23)cc1>>Cc1nnc(C2(C)CCN(C(=O)c3ccc(-c4ccc5ncc(-c6ccc(C#N)cc6)n5c4)cc3)CC2)o1,,CCOC(C)=O,CN(C)C=O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05580866,O=CO.c1ccc2c(c1)CNCCS2>>O=CN1CCSc2ccccc2C1,,Cc1ccccc1,,,,val
US20100286148A1,N#CCBr.O=c1nc(-c2cc(C(F)(F)F)ccn2)[nH]o1>>N#CCn1c(-c2cc(C(F)(F)F)ccn2)noc1=O,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20090221555A1,CCOC(=O)C1Cc2ccc(OC)cc2CC(C(=O)OCC)C1=O>>COc1ccc2c(c1)CCC(=O)CC2,,CCO,,O,[K+].[OH-],val
US20060041129A1,Cc1ccc(C(=O)Cl)cc1.Cc1noc2nc(C(NCCCNC(=O)OC(C)(C)C)C(C)C)n(Cc3ccccc3)c(=O)c12>>Cc1ccc(C(=O)N(CCCNC(=O)OC(C)(C)C)C(c2nc3onc(C)c3c(=O)n2Cc2ccccc2)C(C)C)cc1,,ClCCl,,CCN(CC)CC,,val
US20060111336A1,C[C@@H](c1ccc(F)cc1)[C@H](N=[N+]=[N-])C(=O)N1C(=O)OC[C@@H]1c1ccccc1.OO>>C[C@@H](c1ccc(F)cc1)[C@H](N=[N+]=[N-])C(=O)O,,C1CCOC1,,O,[Li+].[OH-],val
US05843904,CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N(CC(=O)N[C@@H](CC(=O)OC(C)(C)C)C(=O)c1nc(-c2c(Cl)cccc2Cl)co1)Cc1ccccc1>>CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N(CC(=O)N[C@@H](CC(=O)O)C(=O)c1nc(-c2c(Cl)cccc2Cl)co1)Cc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140288326A1,C=C(C)C1CCCCC1=O.CC=NOC>>CON1C(=O)CCCCC=C(C)CC1C,,ClCCCl,,Cl[Sn](Cl)(Cl)Cl,,val
US05296492,CCOC(=O)CC(O)c1ccn(C2=CC(C)(C)Oc3ccc(C#N)cc32)c(=O)c1.S=C(Cl)Oc1ccccc1>>CCOC(=O)CC(OC(=S)Oc1ccccc1)c1ccn(C2=CC(C)(C)Oc3ccc(C#N)cc32)c(=O)c1,CN(C)c1ccncc1,CC#N,,O=C([O-])O.[Na+],,val
US20160145245A1,CC(C)(C)[Si](C)(C)OCCBr.COCCOCCOCCO[C@H]1CCN(C(=O)[C@@H](NC(=O)OC(C)(C)C)c2ccc(O)cc2)C1>>COCCOCCOCCO[C@H]1CCN(C(=O)[C@@H](NC(=O)OC(C)(C)C)c2ccc(OCCO[Si](C)(C)C(C)(C)C)cc2)C1,,CC(C)=O,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20150266890A1,N[C@@H]1CCOC1.O=C(O)c1cccc(S(=O)(=O)Cl)c1>>O=C(O)c1cccc(S(=O)(=O)N[C@@H]2CCOC2)c1,,C1CCOC1,O,,,val
US20100081643A1,COC(=O)c1cc(Oc2nc3cc(-c4ccc(C5(CO)CC5)cc4)c(Cl)cc3n2COCC[Si](C)(C)C)ccc1C>>Cc1ccc(Oc2nc3cc(-c4ccc(C5(CO)CC5)cc4)c(Cl)cc3[nH]2)cc1C(=O)O,,C1COCCO1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20070060754A1,CC(C)N=C=O.CCCn1c(CCOC)nc2c(N)nc3cc(OC4CCNCC4)ccc3c21>>CCCn1c(CCOC)nc2c(N)nc3cc(OC4CCN(C(=O)NC(C)C)CC4)ccc3c21,,ClC(Cl)Cl,,,,val
US20080027049A1,O=[N+]([O-])c1ccc(Cl)cc1.ON=C1CCCCC1>>O=[N+]([O-])c1ccc(ON=C2CCCCC2)cc1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20160039809A1,CC(C)(C)[O-].Cc1cc(-n2nnc3c2C=CN(C(=O)Oc2ccccc2)C3C)ncc1F>>Cc1cc(-n2nnc3c2C=CN(C(=O)OC(C)(C)C)C3C)ncc1F,,C1CCOC1,,O,,val
US20080261999A1,CC(C)(C)OC(=O)N1CC2C=C(c3cc(F)cc(Br)c3)CC(C2)C1.OB(O)c1ccncc1>>CC(C)(C)OC(=O)N1CC2C=C(c3cc(F)cc(-c4ccncc4)c3)CC(C2)C1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,O,[Na+].[OH-],,val
US20100016279A1,CC(C)(C)OC(=O)N1CCCNCC1.FC(F)(F)c1nnc2ccc(Cl)nn12>>CC(C)(C)OC(=O)N1CCCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1,,CCO,,CCN(C(C)C)C(C)C,,val
US20070032530A1,O=S(Cl)Cl.OCc1cncc(-c2cccc(Cl)c2)c1>>ClCc1cncc(-c2cccc(Cl)c2)c1,,ClCCl,,CN(C)C=O,,val
US20080269193A1,CC(=O)/C(C)=N/O.CC1(C)CC(=O)CC(=O)C1>>Cc1[nH]c2c(c1C)C(=O)CC(C)(C)C2,[Zn],CC(=O)O,O,,,val
US20070167476A1,CCOC(=N)CCl.Cc1nc(Oc2ccccc2)c(N)c(NCCNC(=O)OC(C)(C)C)c1C>>Cc1nc(Oc2ccccc2)c2nc(CCl)n(CCNC(=O)OC(C)(C)C)c2c1C,,ClC(Cl)Cl,,Cl,,val
US20080167305A1,CC(C)COC(=O)Cl.Cc1ccc2c(N3CC[C@@H](N)C3)nc(Cl)nc2c1>>Cc1ccc2c(N3CC[C@@H](NC(=O)OCC(C)C)C3)nc(Cl)nc2c1,,ClCCl,,CCN(CC)CC,,val
US20050101637A1,CC(=O)Cl.Cc1ccc(-c2nc(CO[C@@H]3CCC[C@H](CN[C@H](C(=O)OC(C)(C)C)C(C)C)C3)c(C)o2)cc1>>CC(=O)N(C[C@H]1CCC[C@@H](OCc2nc(-c3ccc(C)cc3)oc2C)C1)[C@H](C(=O)O)C(C)C,,ClCCl,O,c1ccncc1,,val
US20090029947A1,C#CCCCCCO.CI>>C#CCCCCCOC,,CN(C)C=O,O,CCOCC,[H-].[Na+],val
US06107291,COc1ccc(S(=O)(=O)N2CC=CCC(C(=O)OCc3ccccc3)C2C(=O)NOC(c2ccccc2)c2ccccc2)cc1>>COc1ccc(S(=O)(=O)N2CC=CCC3C(=O)N(OC(c4ccccc4)c4ccccc4)C(=O)C32)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20050020652A1,CCCN1C(=O)N(Cc2ccc(C)cc2)CC1CCOS(=O)(=O)c1ccc(C)cc1.CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccccc1>>CCCN1C(=O)N(Cc2ccc(C)cc2)CC1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)OCC)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04925649,CCCCCCCC(=O)OCC(O)CO.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCCCCC(=O)OCC(O)COC(c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20020103247A1,OCC#Cc1ccc2c(ccn2-c2ccc(F)cc2)c1>>OCCCc1ccc2c(ccn2-c2ccc(F)cc2)c1,O=[Pt]=O,CO,,,,val
US20040138286A1,CC(C)(C)C(=O)Cl.COCOc1ccc([N+](=O)[O-])cc1OC>>COCOc1ccc(NC(=O)C(C)(C)C)cc1OC,[Pd],CCOC(C)=O,O,c1ccncc1,O=C([O-])O.[Na+],val
US06787561B1,O=C1c2ccccc2C(=O)N1CCCCCBr.Sc1nc2ccc(Cl)cc2[nH]1>>NCCCCCSc1nc2ccc(Cl)cc2[nH]1,,CC#N,,CCN(CC)CC,O,val
US20070105838A1,COC(=O)c1ccc2c(c1)CN(C(=O)OC(C)(C)C)C2>>CC(C)(C)OC(=O)N1Cc2ccc(C(=O)O)cc2C1,,CO,,[Na+].[OH-],,val
US20130072467A1,CN(C)C(=O)[C@@H](N)CO.O=C1NC(=S)CS1>>CN(C)C(=O)[C@H](CO)NC1=NC(=O)SC1,,CCO,,,,val
US05576322,CN=C=O.Nc1nc(NCc2ccc3c(c2)OCO3)c2cc(Cl)ccc2n1>>CNC(=O)Nc1nc(NCc2ccc3c(c2)OCO3)c2cc(Cl)ccc2n1,,CS(C)=O,,,,val
US20110053916A1,CS(=O)c1nc(-c2ccc(S(=O)(=O)NC(C)(C)C)o2)ncc1Cl.Nc1cc(C2CC2)[nH]n1>>CC(C)(C)NS(=O)(=O)c1ccc(-c2ncc(Cl)c(Nc3cc(C4CC4)[nH]n3)n2)o1,,CCCCO,,,,val
US20150353553A1,CC1CCC(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC1O>>CC1CCC(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC1=O,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05616712,CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CC(OC(C)C)=N3)cc1>>CC(C)OC1=Nc2ccc(C#Cc3ccc(C(=O)O)cc3)cc2C(C)(C)C1,,C1CCOC1,CCO,[Li+].[OH-],,val
US20040152598A1,CSCC(C)(C)NC(=O)c1c(I)cccc1C(=O)Nc1ccc(C(C(F)(F)F)C(F)(F)F)cc1C.O=C(OO)c1cccc(Cl)c1>>Cc1cc(C(C(F)(F)F)C(F)(F)F)ccc1NC(=O)c1cccc(I)c1C(=O)NC(C)(C)CS(C)=O,,ClC(Cl)Cl,,,,val
US04447422,C=CCNc1ncc(C(=O)OCC)c(O)n1>>C=CCNc1ncc(C(=O)O)c(O)n1,,O,,[Na+].[OH-],,val
US20100267773A1,COc1ccc(N(C(=O)c2ccc(OC)c(F)c2)c2ccc(F)cc2)cc1>>O=C(c1ccc(O)c(F)c1)N(c1ccc(O)cc1)c1ccc(F)cc1,,ClCCl,,BrB(Br)Br,,val
US06972288B1,Nc1cccc(Cl)c1.O=[N+]([O-])c1cc2c(Cl)ncnc2cc1F>>O=[N+]([O-])c1cc2c(Nc3cccc(Cl)c3)ncnc2cc1F,,C1COCCO1,ClCCl,CCCCCC,,val
US20140349972A1,NO.O=C(c1ccccc1)c1ccc(Br)nc1>>ON=C(c1ccccc1)c1ccc(Br)nc1,,CCO,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20100069394A1,O=P(Cl)(Cl)Cl.O=c1cc(-c2ccc(F)cc2)c(C(F)(F)F)n[nH]1>>Fc1ccc(-c2cc(Cl)nnc2C(F)(F)F)cc1,,CC#N,,ClCCl,O=C([O-])O.[Na+],val
US20160046618A1,OCc1ncco1.Oc1cnc2c(Cl)ncc(F)c2c1>>Fc1cnc(Cl)c2ncc(OCc3ncco3)cc12,,C1CCOC1,O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040162285A1,Nn1c(=O)cc(O)c2ccccc21.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1n1c(=O)cc(O)c2ccccc21,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US05288896,CC(C)(C)c1cc(C(Br)c2ccccc2)cc(C(C)(C)C)c1O.CON.Cl>>CONC(c1ccccc1)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1.Cl,,C1CCOC1,,Cc1cccc(C)n1,,val
US05861529,CI.COC(=O)c1cccc2c(NC[C@H](CSC(c3ccccc3)(c3ccccc3)c3ccccc3)NC(=O)OC(C)(C)C)cccc12>>COC(=O)c1cccc2c(N(C)C[C@H](CSC(c3ccccc3)(c3ccccc3)c3ccccc3)NC(=O)OC(C)(C)C)cccc12,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20110262352A1,O=Cc1cc(F)ccc1N1CCN(C(=O)C2COc3ccccc3O2)CC1>>OCc1cc(F)ccc1N1CCN(CC2COc3ccccc3O2)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100022477A1,CCOP(=O)(Cc1ccc2cc(Br)c(C(F)(F)P(=O)(OCC)OCC)cc2c1)OCC.COC(=O)c1cccc(C=O)c1>>CCOP(=O)(OCC)C(F)(F)c1cc2cc(/C=C/c3cccc(C(=O)OC)c3)ccc2cc1Br,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20100087424A1,CC(C)(C)OC(=O)NC1CCN(C[C@H]2COc3c(F)cnc4ccc(=O)n2c34)CC1.Cl.ClCCl>>Cl.Cl.NC1CCN(C[C@H]2COc3c(F)cnc4ccc(=O)n2c34)CC1,,ClCCl,,C1COCCO1,,val
US20090131416A1,NCC(N)=O.O=CC(=O)c1ccco1>>Oc1cnc(-c2ccco2)cn1,,CO,O,Cl,[Na+].[OH-],val
US20030105333A1,Cc1ccc(CCC(O)C(C)C)cc1>>Cc1ccc2c(c1)C(C)(C)CCC2,,ClCCl,,,,val
US04354973,Fc1ccccc1C1=NCc2c[nH]cc2-c2ccc(Cl)cc21.O=C(Cl)C(Cl)(Cl)Cl>>O=C(c1[nH]cc2c1CN=C(c1ccccc1F)c1cc(Cl)ccc1-2)C(Cl)(Cl)Cl,,ClCCl,,,,val
US20080114016A1,C1=COCCC1.Cc1n[nH]cc1C(=O)O>>Cc1nn(C2CCCCO2)cc1C(=O)O,,CCOC(C)=O,CN(C)C=O,Cc1ccc(S(=O)(=O)O)cc1,,val
US05801201,Cc1ccc(S(=O)(=O)OC2CCC3(CC2)OCCO3)cc1.Oc1ccccc1>>c1ccc(OC2CCC3(CC2)OCCO3)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20060199787A1,COP(=O)(OC)C(=O)c1ccc(Cl)cc1>>O=C(c1ccc(Cl)cc1)P(=O)(O)O,,C1COCCO1,CO,[Na+].[OH-],,val
US20100216810A1,Nc1ccc(F)c([N+](=O)[O-])c1.O=C(Nc1cccc(C(F)(F)F)c1)c1cccc(O)c1>>Nc1ccc(Oc2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)c([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06051722,CCNc1ccc(Br)cc1.OCCCCCCBr>>CCN(CCCCCCO)c1ccc(Br)cc1,,O,,CCN(C(C)C)C(C)C,,val
US05206235,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCC[C@@H](N)C(=O)O>>CCC[C@@H](NC(=O)OC(C)(C)C)C(=O)O,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20120190649A1,C=CC(=O)OC.CC(C)(N)c1ccc2cc(O[C@@H]3CC[C@@H](C(C)(C)C)CC3)ccc2c1>>COC(=O)CCNC(C)(C)c1ccc2cc(O[C@@H]3CC[C@@H](C(C)(C)C)CC3)ccc2c1,,CO,,,,val
US20100324046A1,CCOC(=O)c1cn(C[Si](C)(C)C)nn1>>C[Si](C)(C)Cn1cc(CO)nn1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20020128255A1,COC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O,,CO,O,[Li+].[OH-],,val
US05618827,CS(=O)(=O)NCCBr.OCC1CCNCC1>>CS(=O)(=O)NCCN1CCC(CO)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US05070089,COc1cccc(CCl)c1.CSC(=S)N1CCNCC1>>COc1cccc(CN2CCN(C(=S)SC)CC2)c1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20040171881A1,CCCCn1ccc2ccc(C(=O)OC)cc21>>CCCCN1CCc2ccc(C(=O)OC)cc21,,CC(=O)O,,[BH3-]C#N.[Na+],,val
US05665768,ON=C1C=C(c2ccc(Sc3ccc(F)cc3)o2)CC1>>ONC1C=C(c2ccc(Sc3ccc(F)cc3)o2)CC1,,CC(=O)O,,[BH3-]C#N.[Na+],,val
US20030040533A1,COC(=O)C(Cc1ccc(OCCn2c(=O)sc3cc(C(=O)c4cccc5ccccc45)ccc32)cc1)C(=O)OC>>COC(=O)C(Cc1ccc(OCCn2c(=O)sc3cc(Cc4cccc5ccccc45)ccc32)cc1)C(=O)OC,,Cc1ccccc1,,,,val
US20020026060A1,CCCCCC(CO)c1ccc2c(c1)C(C)(C)CC(C)(C)O2.COC(=O)c1ccc(O)cc1>>CCCCCC(COc1ccc(C(=O)OC)cc1)c1ccc2c(c1)C(C)(C)CC(C)(C)O2,,C1CCOC1,CCOCC,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080287453A1,CC(C)(C)OC(=O)N1CCNCC1.Clc1ccc2[nH]c(Cl)nc2c1>>CC(C)(C)OC(=O)N1CCN(c2nc3cc(Cl)ccc3[nH]2)CC1,,CCN(CC)CC,,CCO,,val
US20140051672A1,COc1cc(-n2cccn2)ccc1-c1ccc(Cl)nn1.C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1CC(O)CC(C)(C)N1>>COc1cc(-n2cccn2)ccc1-c1ccc(OC2C[C@@H]([C@H](C)O[Si](C)(C)C(C)(C)C)NC(C)(C)C2)nn1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20070124152A1,CCOC(=O)c1c(O)c2ncc(Cc3ccccc3)cc2n(Cc2ccc(S(C)(=O)=O)cc2)c1=O.NCc1ccncc1>>CS(=O)(=O)c1ccc(Cn2c(=O)c(C(=O)NCc3ccncc3)c(O)c3ncc(Cc4ccccc4)cc32)cc1,,CCO,,,,val
US20130029983A1,CC(C)N.Nc1scc2c(C(=O)O)nn(-c3ccc(Cl)cc3)c(=O)c12>>CC(C)NC(=O)c1nn(-c2ccc(Cl)cc2)c(=O)c2c(N)scc12,,CS(C)=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20160039832A1,CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cn3)nc2n1C1CCCC1>>CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1,,Cc1ccccc1,,Cl,,val
US20090018132A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(OCC1(c2ccc(F)cc2)CCNCC1)c1cc(N(C)C)cc2c[nH]nc12>>CC(OCC1(c2ccc(F)cc2)CCN(C(=O)OC(C)(C)C)CC1)c1cc(N(C)C)cc2cn[nH]c12,,ClCCl,,,,val
US06107301,COc1cc(Br)c(-n2cc(C#N)c3c(C)cc(C)nc32)c(OC)c1>>COc1cc(Br)c(-n2ccc3c(C)cc(C)nc32)c(OC)c1,,O=S(=O)(O)O,,,,val
US20120053192A1,CS(=O)(=O)O.NC(N)=O>>CS(=O)(=O)O.NC(N)=O,,CCOCC,,CCO,,val
US20100010034A1,CCOC(=O)Cc1c(C)cn2cc(C#N)ccc12.CS(=O)(=O)c1ccc(C=O)cc1>>CCOC(=O)Cc1c(C)c(Cc2ccc(S(C)(=O)=O)cc2)n2cc(C#N)ccc12,,ClCCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20030007927A1,COC(=O)C(Cc1ccc(O)cc1)NC(=O)C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1>>CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)NC(Cc1ccc(O)cc1)C(=O)O,,C1CCOC1,O,[Li+].[OH-],,val
US04911747,COC(=O)c1ccccc1C1=NC(C)(C(C)C)C(=S)N1.Cl>>COC(=O)c1ccccc1C1=NC(C)(C(C)C)C(=S)N1.Cl,,CCOCC,,,,val
US20120316151A1,CC(C)(C)OC(=O)N1CC(CC(=O)NNC(=O)Nc2ccc(Br)cc2)C1.CCC(=O)Cl>>CCC(=O)N1CC(Cc2nn(C(=O)CC)c(=O)n2-c2ccc(Br)cc2)C1,,ClCCl,O,CCN(C(C)C)C(C)C,O=C([O-])[O-].[K+].[K+],val
US20100305133A1,CCOC(=O)CNC(=O)c1c(O)c(-c2cc3ccccc3n2C(=O)OC(C)(C)C)cc2nccnc12>>O=C(O)CNC(=O)c1c(O)c(-c2cc3ccccc3[nH]2)cc2nccnc12,,CCO,,[Na+].[OH-],,val
US20030073850A1,CS(=O)(=O)Cl.O=C1CCCc2c(NCc3ccccc3)ccc(F)c21>>CS(=O)(=O)N(Cc1ccccc1)c1ccc(F)c2c1CCCC2=O,,ClCCl,,O,c1ccncc1,val
US06093718,Cc1nccc(Cl)n1.O=C(C1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CCNCC1>>Cc1nccc(N2CCN(C(=O)C3CCN(S(=O)(=O)c4ccc(Cl)cc4)CC3)CC2)n1,,CCO,,CCN(CC)CC,Cl,val
US20090093454A1,Fc1cccc2nc(CCl)cn12.c1cnc2c(c1)CC[C@H]1CCCN[C@@H]21>>Fc1cccc2nc(CN3CCC[C@@H]4CCc5cccnc5[C@@H]43)cn12,,CC#N,,[I-].[K+],,val
US20130158041A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cn1cc(-n2ccc(=O)c(COc3ccc4ncccc4c3)n2)cn1>>Cn1cc(-n2ccc(=S)c(COc3ccc4ncccc4c3)n2)cn1,,C1COCCO1,,,,val
US20090264426A1,O=C(O)C1Cc2ccccc2N1.O=[N+]([O-])O>>O=C(O)C1Cc2ccc([N+](=O)[O-])cc2N1,,O,,O=S(=O)(O)O,,val
US20070135408A1,CC(C)(C)OC(=O)N1CC=C(CO)CC1.O=C(Nc1ccsc1I)C(F)(F)F>>CC(C)(C)OC(=O)N1CC=C(CN(C(=O)C(F)(F)F)c2ccsc2I)CC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05428162,Cc1ccc(O)cc1.O=C(O)C(O)c1ccc(OCCO)cc1>>Cc1ccc2c(c1)C(c1ccc(OCCO)cc1)C(=O)O2,,O,,,,val
US20150203483A1,COc1cc(CC(C)=O)c(C(=O)c2ccc(Br)cc2)cc1OC.NN>>COc1cc2c(cc1OC)C(c1ccc(Br)cc1)=NN=C(C)C2,,CCO,O,Cl,[Na+].[OH-],val
US20130252934A1,CS(=O)(=O)c1nccc(-c2ccn(C(c3ccc(Cl)c(F)c3)c3cnco3)c(=O)c2)n1.NC1CCOCC1>>O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(c1ccc(Cl)c(F)c1)c1cnco1,,CC(=O)N(C)C,CCOC(C)=O,,,val
US20040014962A1,CC(C)(C)[Si](OC1CN(c2nc(C(=O)N3CCSCC3)cs2)C1)(c1ccccc1)c1ccccc1>>O=C(c1csc(N2CC(O)C2)n1)N1CCSCC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160214940A1,CCOC(=O)c1cn(-c2ccc(F)cc2)c2ccc(C=O)cc2c1=O>>CCOC(=O)c1cn(-c2ccc(F)cc2)c2ccc(CO)cc2c1=O,,CCO,CCOC(C)=O,[BH4-].[Na+],,val
US20050085519A1,O=C(Nc1ccccc1[N+](=O)[O-])c1cc([N+](=O)[O-])ccc1Cl>>Nc1ccc(Cl)c(-c2nc3ccccc3[nH]2)c1,[Fe],CC(=O)O,Cc1ccccc1,,,val
US20110183976A1,COc1ccc(CC(=O)OCC(=O)c2ccc(OCc3ccccc3)cc2)cc1>>COc1ccc(C2=C(c3ccc(OCc4ccccc4)cc3)COC2=O)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20060111375A1,Cc1ccncc1C(=O)c1cc(C)c(C)o1.N>>Cc1ccncc1-c1nc(C)c(C)cc1O,,CO,,,,val
US20100331320A1,CC(C)C1(CCC(C)(C)O)CCN([C@@H](C)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)C(=O)O1.C[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CCC(CC(C)(C)O)(C2CC2)OC1=O.Cn1ccc(I)cc1=O>>CC(C)C1(CCC(C)(C)O)CCN([C@@H](C)c2ccc(-c3ccn(C)c(=O)c3)cc2)C(=O)O1.C[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CCC(CC(C)(C)O)(C2CC2)OC1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,COCCOC,O=C([O-])O.[Na+],,val
US20150152069A1,CC(=O)N1CCNCC1.CCCOc1cc(F)ccc1[N+](=O)[O-]>>CCCOc1cc(N2CCN(C(C)=O)CC2)ccc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050032672A1,CCCC[Sn]=O.Cc1ccccc1.O=C(O)c1ccccc1O>>CC1=CCC(COC(=O)c2ccccc2O)CC1,,Cc1ccccc1,,,,val
US20020177589A1,CS(=O)(=O)Cl.N#Cc1ccc(-c2ccc3oc(CCO)cc3c2)cc1>>CCCS(=O)(=O)c1cc2cc(-c3ccc(C#N)cc3)ccc2o1,,ClCCl,,CCN(CC)CC,,val
US20140135318A1,CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)NS(=O)(=O)c3ccc4ccccc4c3)cc2C(=O)O)c(C)c1Cl.COC(=O)[C@H]1Cc2ccccc2CN1>>CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)NS(=O)(=O)c3ccc4ccccc4c3)cc2C(=O)N2Cc3ccccc3C[C@@H]2C(=O)OC)c(C)c1Cl,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US05387677,Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O.N=C(N)N>>Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O.N=C(N)N,,O,,Cl,[Na+].[OH-],val
US20160116448A1,CCNCC.O=C(Cl)Cc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>CCN(CC)C(=O)Cc1ccc([N+](=O)[O-])cc1[N+](=O)[O-],,ClCCl,,,,val
US20060084680A1,CCOC(=O)Cc1nc(Cl)ccc1C.COc1ccc(B(O)O)cc1>>CCOC(=O)Cc1nc(-c2ccc(OC)cc2)ccc1C,,Cc1ccccc1,O,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20160102357A1,Cc1ccnc(-c2cc(CBr)ccn2)c1.O=c1[nH]cc(F)c(=O)[nH]1>>Cc1ccnc(-c2cc(Cn3cc(F)c(=O)[nH]c3=O)ccn2)c1,,CS(C)=O,,,,val
US05284863,BrBr.O=[N+]([O-])c1cc(SC(F)(F)F)[nH]c1-c1ccc(Cl)cc1>>O=[N+]([O-])c1c(-c2ccc(Cl)cc2)[nH]c(SC(F)(F)F)c1Br,,CC(=O)O,,O,CC(=O)[O-].[Na+],val
US06492416B1,BrBr.CS(=O)c1ccc(C2=CC(=O)C(C)(C)O2)cc1>>CS(=O)c1ccc(C2=C(Br)C(=O)C(C)(C)O2)cc1,,ClC(Cl)(Cl)Cl,,CC(=O)O,,val
US04455315,Nc1ccccc1OC(F)F.O=C1OC(=O)C(Cl)=C1Cl>>O=C1C(Cl)=C(Cl)C(=O)N1c1ccccc1OC(F)F,,C1COCCO1,,,,val
US04684648,CCOC=C(C(=O)OCC)C(=O)c1cc(F)c(F)c(F)c1F.COc1ccc(N)cc1>>CCOC(=O)c1cn(-c2ccc(OC)cc2)c2c(F)c(F)c(F)cc2c1=O,,CCO,,,,val
US20110160212A1,Cc1nnc(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)n(Cc2cc(F)ccc2Br)c1=O>>Cc1nnc(N2CCC[C@@H](N)C2)n(Cc2cccc(F)c2)c1=O,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US05254557,CC1(C)Oc2ccc(C#N)cc2C2OC21.O=c1ccnc[nH]1>>CC1(C)Oc2ccc(C#N)cc2[C@@H](n2cnccc2=O)[C@@H]1O,,CCOC(C)=O,CS(C)=O,O,CC(C)(C)[O-].[K+],val
US20010027196A1,CS(=O)c1nc(N)nc(-n2cccn2)c1C#N.NCc1ccccc1Cl>>N#Cc1c(NCc2ccccc2Cl)nc(N)nc1-n1cccn1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20050272778A1,CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccc(C2=CC(=O)NS2(=O)=O)cc1)c1nc2ccccc2[nH]1>>CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccc(C2CC(=O)NS2(=O)=O)cc1)c1nc2ccccc2[nH]1,[Pd],CO,,,,val
US20150126490A1,Nc1ccc(C2CCS(=O)(=O)CC2)cn1.O=C1CCC(=O)N1Br>>Nc1ncc(C2CCS(=O)(=O)CC2)cc1Br,,CCOC(C)=O,ClCCl,,,val
US05409943,Cc1ccccc1COc1cccnc1N.S=C=Nc1ccc(Cl)cc1>>Cc1ccccc1COc1cccnc1NC(=S)Nc1ccc(Cl)cc1,,CCOCC,,Cc1ccccc1,,val
US20150284395A1,CCOC(CBr)OCC.Cn1ncc2cc(-c3cc(=O)n4ncc(C(N)=O)c4[nH]3)ccc21>>Cn1ncc2cc(-c3cc(=O)n4ncc(-c5ncco5)c4[nH]3)ccc21,,CN1CCCC1=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US06143764,CC(C)(C)c1ccc(CN)cc1.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)NCc4ccc(C(C)(C)C)cc4)cc3)c2cc1OC,,CCN(CC)CC,Cc1ccccc1,O=C([O-])O.[Na+],,val
US20100087502A1,COc1cc(O)c2cnn(-c3ccc(OCc4ccccc4)c(F)c3)c2c1>>COc1cc(O)c2cnn(-c3ccc(O)c(F)c3)c2c1,[Pd],CCO,CCOC(C)=O,,,val
US20120122842A1,C=Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NCCC)cc1)C2.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>CCCNC(=O)c1ccc(NC(=O)N2Cc3ccc(C(O)CO)cc3C2)cc1,O=[Os](=O)(=O)=O,CC(C)O,,C1CCOC1,,val
US20100173909A1,COC(=O)c1sc(Cl)nc1-c1nccc(N2CCCCC2)n1.CO[C@H]1CNCC[C@H]1NC(=O)c1[nH]c(C)c(Cl)c1Cl>>COC(=O)c1sc(N2CC[C@@H](NC(=O)c3[nH]c(C)c(Cl)c3Cl)[C@@H](OC)C2)nc1-c1nccc(N2CCCCC2)n1,,CN1CCCC1=O,O,CCN(C(C)C)C(C)C,,val
US06239131B1,Cc1ccc2c(c1)N(CC(=O)C(C)(C)C)C(=O)C(N)CN2c1ccccc1.O=C(O)c1cccc(C(=O)OCc2ccccc2)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cc1ccc2c(c1)N(CC(=O)C(C)(C)C)C(=O)C(NC(=O)Nc1cccc(C(=O)OCc3ccccc3)c1)CN2c1ccccc1,,C1COCCO1,,CCN(CC)CC,,val
US05772990,CCNc1cc(Cl)nc(N)n1.O=C(OO)c1cccc(Cl)c1>>CCNc1cc(Cl)nc(N)[n+]1[O-],,CCO,,,,val
US20120088748A1,CC(C)(C)[Si](C)(C)OCC(CNCc1ccccc1)C(O)c1ccc(F)c(Cl)c1.O=C(Cl)CCl>>CC(C)(C)[Si](C)(C)OCC1CN(Cc2ccccc2)C(=O)COC1c1ccc(F)c(Cl)c1,,C1CCOC1,,CCN(CC)CC,,val
US20110275611A1,COc1ccc(N)cc1.N#Cc1ccc(-c2cc(N3CCC[C@H](C(=O)O)C3)nc(N)n2)cc1F>>COc1ccc(NC(=O)[C@H]2CCCN(c3cc(-c4ccc(C#N)c(F)c4)nc(N)n3)C2)cc1,,CCOC(C)=O,CN(C)C=O,ClCCCl,On1nnc2ccccc21,val
US20160122335A1,Nc1cccc2c1CCCO2.O=C1CCC(=O)N1Br>>Nc1ccc(Br)c2c1CCCO2,,ClCCl,,,,val
US05124322,CCOC(=O)Cl.COc1cccc(CN(C)C)c1SCc1ccccc1>>COc1cccc(CCl)c1SCc1ccccc1,,CCOCC,,,,val
US20020031834A1,BrBr.CCOC(=O)c1ccc2ccccn2c1=O>>CCOC(=O)c1cc(Br)c2ccccn2c1=O,,CC(=O)O,,CCOC(C)=O,,val
US20110021522A1,COc1ccc(OC)c(-c2cccc(N)c2)c1.O=C(O)c1cc2cccc(O)c2oc1=O>>COc1ccc(OC)c(-c2cccc(NC(=O)c3cc4cccc(O)c4oc3=O)c2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US07728014B2,C=CN1CCCC1.CCOC(=O)c1nnc(-c2ccc(CC)cc2)c(-c2ccccc2)n1>>CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccccc2)n1,,ClC(Cl)Cl,,,,val
US20160229869A1,COC(=O)C1=CC[C@@H]2CCC1N2C>>CN1C2CC[C@H]1CC=C2C(=O)O,,Cl,,[K+].[OH-],,val
US20120264748A1,Cc1ccc(S(=O)(=O)n2cc(CO)c3ccccc32)cc1.O=P(Cl)(Cl)Cl>>Cc1ccc(S(=O)(=O)n2cc(CCl)c3ccccc32)cc1,,C1CCOC1,,,,val
US05055585,C#CC(O)CC.ON=Cc1ccccc1>>CCC(O)c1cc(-c2ccccc2)no1,,ClCCl,,[Na+].[O-]Cl,,val
US06399612B1,COC(=O)CCC(=O)c1ccc(-c2ccc(Cl)s2)cc1>>O=C(O)CCC(=O)c1ccc(-c2ccc(Cl)s2)cc1,,CO,,C1CCOC1,[Na+].[OH-],val
US05866576,CC=CCCCOS(C)(=O)=O.Cn1cnc2c1c(=O)[nH]c(=O)n2C>>CC=CCCCn1c(=O)c2c(ncn2C)n(C)c1=O,,CS(C)=O,,O,[H-].[Na+],val
US20070249620A1,CC(C)(C)OC(=O)N1CCN(c2ccc(N)cn2)CC1.COc1ccc(C)cc1N=C=O>>COc1ccc(C)cc1NC(=O)Nc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1,,C1CCOC1,,CO,,val
US20110021537A1,COC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NCCF)n(-c2ccccc2)n1>>CC(C)(C)OC(=O)CC[C@H](NC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NCCF)n(-c2ccccc2)n1)C(=O)O,,C1CCOC1,,[Li+].[OH-],,val
US20090252679A1,Nc1ccc(Br)cn1.O=C(CBr)c1ccc(O)cc1>>Br.Oc1ccc(-c2cn3cc(Br)ccc3n2)cc1,,CC#N,,,,val
US05086070,CC(C)(C)NCCCOc1ccccc1C(=O)c1cccc2[nH]ccc12.O=C1CCC(=O)N1Cl>>CC(C)(C)NCCCOc1ccccc1C(=O)c1cccc2[nH]cc(Cl)c12,,CC(=O)O,,O=C([O-])[O-].[Na+].[Na+],,val
US05221685,Cc1ccccc1C(=O)N=C=O.N=C1NC(C(F)(F)F)(C(F)(F)F)C(=C(F)C(F)(F)F)S1>>Cc1ccccc1C(=O)NC(=O)NC1=NC(C(F)(F)F)(C(F)(F)F)C(=C(F)C(F)(F)F)S1,,Cc1ccccc1,,,,val
US20040132727A1,CC(O)c1ccc(OC(F)(F)F)cc1.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3cc(C)c(NC(=O)OC(C)c4cccc(OC(F)(F)F)c4)cc3C)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US20070287838A1,Nc1nccc(Oc2ccc(NC(=O)C(F)(F)F)c(F)c2)c1[N+](=O)[O-]>>Nc1nccc(Oc2ccc(NC(=O)C(F)(F)F)c(F)c2)c1N,[Pd],CCO,CCOC(C)=O,[H][H],,val
US20080045528A1,CNC(=O)c1cc(Cl)ccn1.Cc1cc(O)ccc1N>>CNC(=O)c1cc(Oc2ccc(N)c(C)c2)ccn1,,CN1CCCC1=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100197683A1,C=CCOC1CCC(n2c(=O)c(Cc3ccc(-c4ccccc4C#N)cc3)c(CCC)n3ncnc23)CC1.O=C([O-])O.[NH3+]O>>C=CCOC1CCC(n2c(=O)c(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c(CCC)n3ncnc23)CC1,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20100216798A1,N[C@H]1CC[C@H](O)CC1.O=[N+]([O-])c1cnc2ccc(Cl)nn12>>O=[N+]([O-])c1cnc2ccc(N[C@@H]3CC[C@@H](O)CC3)nn12,,CS(C)=O,,O,,val
US20120129875A1,CCCC[Sn](Cl)(CCCC)CCCC.Cc1ccc(Br)nc1-c1ccccc1>>CCCC[Sn](CCCC)(CCCC)c1ccc(C)c(-c2ccccc2)n1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20130259850A1,CCOC(=O)Cc1ccc(OC)c(O)c1.Cc1cccc(C)c1CO>>CCOC(=O)Cc1ccc(OC)c(OCc2c(C)cccc2C)c1,,C1CCOC1,CCOCC,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110152245A1,CC(C)(C)OC(=O)Nc1ccc(C2CC(=O)N(Cc3ccccc3)C2=O)cc1.CI>>CC(C)(C)OC(=O)Nc1ccc(C2(C)CC(=O)N(Cc3ccccc3)C2=O)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060069110A1,CC(Cc1cccc(CO)c1)Nc1nccc(N(C)c2cc(N)nc(-c3ccccc3)n2)n1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(Cc1cccc(CN=[N+]=[N-])c1)Nc1nccc(N(C)c2cc(N)nc(-c3ccccc3)n2)n1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20060004013A1,O=C1NC(=O)c2ccccc21.OCc1ccc(N2CCOCC2)nc1>>O=C1c2ccccc2C(=O)N1Cc1ccc(N2CCOCC2)nc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130225635A1,CC(C)(C)OC(=O)N1CC2CNCC2C1.O=C(Cl)c1ccccc1>>CC(C)(C)OC(=O)N1CC2CN(C(=O)c3ccccc3)CC2C1,,C1CCOC1,,CCN(CC)CC,,val
US20060258666A1,CC1(C)CC=C(c2cc(CC#N)ccc2N)CC1.C[Sn](C)(C)N=[N+]=[N-]>>CC1(C)CC=C(c2cc(Cc3nnnn3[Sn](C)(C)C)ccc2N)CC1,,Cc1ccccc1,,,,val
US20040249153A1,CC(C)(C)CN.ClCc1cnc(Cl)nc1Cl>>CC(C)(C)CNc1nc(Cl)ncc1CCl,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US05726172,COc1c(C(=O)O)cc(F)c(O)c1C.C[C@H](O)c1ccncc1>>COC(=O)c1cc(F)c(O[C@@H](C)c2ccncc2)cc1OC,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120213806A1,C[C@@](CO)(C[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)OCCN1CCCC1=O.O=C(O)c1c[nH]nn1>>C[C@@](CO)(C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cnn[nH]1)C(=O)OCCN1CCCC1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04225711,CO.CS(=O)CC(=O)c1[nH]c2cc(Br)c(Cl)cc2c1-c1ccccn1>>COC(SC)C(=O)c1[nH]c2cc(Br)c(Cl)cc2c1-c1ccccn1,,C1CCOC1,,Cl,O,val
US20040132727A1,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCCOc1ccccc1Cl>>COc1cc2nccc(Oc3ccc(NC(=O)OCCCOc4ccccc4Cl)cc3)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US20030069297A1,CNCC(O)CN1CCCC1.Cc1cc(C(=O)O)c(/C=C2\C(=O)Nc3cccc(-c4cccc(F)c4F)c32)[nH]1>>Cc1cc(C(=O)N(C)CC(O)CN2CCCC2)c(/C=C2\C(=O)Nc3cccc(-c4cccc(F)c4F)c32)[nH]1,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20090192195A1,Cc1ccc(S(=O)(=O)Cl)cc1.OC1CCC1>>Cc1ccc(S(=O)(=O)OC2CCC2)cc1,,c1ccncc1,,Cl,,val
US20100216746A1,Cc1nc(Cl)c(C(=O)O)[nH]1.NCc1ccc(Cl)c(Oc2ccccc2)c1F>>Cc1nc(Cl)c(C(=O)NCc2ccc(Cl)c(Oc3ccccc3)c2F)[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080085886A1,CI.O=C(O)[C@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1>>COC(=O)[C@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20120077979A1,CC1(C)OB(c2ccc3ccc(-c4ccncc4)nc3c2)OC1(C)C.Nc1nccn2c(C3CCC3)nc(Br)c12>>Nc1nccn2c(C3CCC3)nc(-c3ccc4ccc(-c5ccncc5)nc4c3)c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,N#N,O=C([O-])[O-].[Na+].[Na+],val
US20060069143A1,ClCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.Clc1cccc2[nH]ccc12>>Clc1cccc2c1ccn2Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,,CS(C)=O,O,[K+].[OH-],,val
US20050090498A1,CCOC(=O)Cc1ccc2ccccc2n1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>CCOC(=O)C(=C1C=Cc2ccccc2N1)c1nc(Cl)ncc1[N+](=O)[O-],,CC(=O)O,,,,val
US07122543B2,COC1=C(OC)C(=O)C(Cc2ccc(C(=O)O)c(-c3cccnc3)c2)=C(C)C1=O.COc1ccc(N)cc1>>COC1=C(OC)C(=O)C(Cc2ccc(C(=O)Nc3ccc(OC)cc3)c(-c3cccnc3)c2)=C(C)C1=O,,ClCCl,O,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US20020040146A1,CC(O)=S.O=S(=O)(c1ccc2ccccc2c1)N1C[C@H](O)C[C@H]1COCc1ccccc1>>CC(=O)S[C@H]1C[C@@H](COCc2ccccc2)N(S(=O)(=O)c2ccc3ccccc3c2)C1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04317830,ClCCC1CC=CCC1.c1c[nH]cn1>>C1=CCC(CCn2ccnc2)CC1,,CCCCO,,CC(C)(C)[O-].[K+],,val
US06177440B1,COC(=O)c1cccc2c1c1c(O)cccc1n2Cc1cccc(C(F)(F)F)c1.[NH4+]>>NC(=O)c1cccc2c1c1c(O)cccc1n2Cc1cccc(C(F)(F)F)c1,,C1CCOC1,CCOC(C)=O,Cl,,val
US20160096839A1,C#CC(=O)OCC.COc1cc(-c2cc(Cl)ccc2N)ncn1.C[Si](C)(C)N=[N+]=[N-]>>CCOC(=O)c1cn(-c2ccc(Cl)cc2-c2cc(OC)ncn2)nn1,,CC#N,ClCCl,CC(C)CCON=O,,val
US05773628,CC(=O)Cl.Oc1cccc(C2(OCC(F)(F)F)OOC23C2CC4CC(C2)CC3C4)c1>>CC(=O)Oc1cccc(C2(OCC(F)(F)F)OOC23C2CC4CC(C2)CC3C4)c1,,ClCCl,,c1ccncc1,,val
US20060183800A1,CC1CCOS1(=O)=O.C[C@H](N)c1ccc(F)cc1>>CC(CCN[C@@H](C)c1ccc(F)cc1)S(=O)(=O)O,,CC#N,,Cc1ccccc1,,val
US04436549,CCC(C)(CC)C1=NN=C(N)SC1.COc1cccc(OC)c1C(=O)Cl>>CCC(C)(CC)C1=NN=C(NC(=O)c2c(OC)cccc2OC)SC1,,ClCCl,c1ccncc1,O,,val
US20080255197A1,CC(NC1CCN(C(=O)OC(C)(C)C)CC1)c1ccccn1.Cc1cnc(C=O)c(C)c1>>Cc1cnc(CN(C2CCN(C(=O)OC(C)(C)C)CC2)C(C)c2ccccn2)c(C)c1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110237639A1,N#CCc1ccc([N+](=O)[O-])c(Cl)c1Br>>N#CCc1ccc(N)c(Cl)c1Br,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20120129840A1,CCCC(C(=O)OC)c1c(C)nc(N2CCCC(C(=O)NCC(C)C)C2)nc1-c1ccc(C)cc1>>CCCC(C(=O)O)c1c(C)nc(N2CCCC(C(=O)NCC(C)C)C2)nc1-c1ccc(C)cc1,,CO,,[Na+].[OH-],,val
US20070249593A1,CC(C)(C)OC(=O)Nc1ccc(C2CNC(=O)NC2)cc1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)Nc1ccc(C2CNC(=O)NC2)cc1Br,,CC#N,,,,val
US20130345192A1,Cc1ccc(S(=O)(=O)n2ccc3c(N[C@H]4CCCN(C(=O)CNc5cc(F)cc(Cl)c5)C4)ncnc32)cc1>>O=C(CNc1cc(F)cc(Cl)c1)N1CCC[C@H](Nc2ncnc3[nH]ccc23)C1,,CCOC(C)=O,CO,O,O=C([O-])[O-].[K+].[K+],val
US20140315917A1,O=C(NCCCl)NCC(F)(F)F>>O=C1NCCN1CC(F)(F)F,,C1CCOC1,,[H-].[Na+],,val
US05534515,Cc1c(C=O)c2cnnc(OCc3ccccc3)c2n1Cc1ccccc1>>Cc1c(CO)c2cnnc(OCc3ccccc3)c2n1Cc1ccccc1,,CCO,,[BH4-].[Na+],,val
US20110251173A1,CN(Cc1ccc(-c2ccc(N3CCOc4ncnc(N)c4C3=O)cc2)c(Cl)c1)C(=O)CCNC(=O)OC(C)(C)C>>CN(Cc1ccc(-c2ccc(N3CCOc4ncnc(N)c4C3=O)cc2)c(Cl)c1)C(=O)CCN,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050124586A1,Cc1ccc(CCl)cn1>>Cc1ccc(CCl)cn1,,ClCCl,,Cl,[Na+].[OH-],val
US05064832,N#Cc1cccc(-c2ccncc2)c1.OO>>N#Cc1cccc(-c2cc[n+]([O-])cc2)c1,,CC(=O)O,,,,val
US20030220364A1,Cc1cccc(C(=O)O)c1CNc1cccn2c(C)c(C)nc12.ClCCl>>Cc1cccc(CO)c1CNc1cccn2c(C)c(C)nc12.Cl,,Cc1ccccc1,,O,,val
US20090281142A1,CCOC(=O)/C(=C/C1CCCC1)c1ccc(S(=O)(=O)CC2CC2)cc1>>O=C(O)/C(=C/C1CCCC1)c1ccc(S(=O)(=O)CC2CC2)cc1,,CCO,,Cl,[K+].[OH-],val
US20070010511A1,Cc1cccc(C(C)(C)O)c1N.NC(N)=O>>Cc1cccc2c1NC(=O)OC2(C)C,,CCOCC,,,,val
US20070244120A1,CC(C)(C)OC(=O)n1nc(N)cc1C(C)(C)C.Nc1cccc(Sc2ccncc2)c1>>CC(C)(C)c1cc(NC(=O)Nc2cccc(Sc3ccncc3)c2)[nH]n1,,ClCCl,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US20100249139A1,CC(C=O)c1ccc(Oc2ccc(C#N)cc2)cc1Cl.Cc1cc(Br)ccn1>>Cc1cc(C(O)C(C)c2ccc(Oc3ccc(C#N)cc3)cc2Cl)ccn1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US06723722B1,C=O.O=C1CN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CCN1NC1CCN(c2ccncc2)CC1>>CN(C1CCN(c2ccncc2)CC1)N1CCN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CC1=O,,O=CO,,[Na+].[OH-],,val
US20050059702A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=Cc1ncc[nH]1>>Cc1ccc(S(=O)(=O)n2ccnc2C=O)cc1,,ClCCl,,CCN(CC)CC,,val
US20140349990A1,CCOC(=O)c1nn(Cc2ccc(OC)cc2)c(C)c1C(O)c1ccc(Cl)cc1.Cc1cc(N)cn(C)c1=O>>CCOC(=O)c1nn(Cc2ccc(OC)cc2)c(C)c1C(Nc1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1,,CO,ClCCl,,,val
US20150218141A1,CC(C)(C)OC(=O)N1CCCC(c2ccc(F)c(O)c2)C1.COCCBr>>COCCOc1cc(C2CCCN(C(=O)OC(C)(C)C)C2)ccc1F,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US03975531,CSC1C(=O)Nc2c(C(=O)c3ccc(Cl)cc3)cccc21>>O=C1Cc2cccc(C(=O)c3ccc(Cl)cc3)c2N1,,C1CCOC1,,,,val
US20090298829A1,CN(C)C(=O)[C@@H]1C[C@H](N(C(=O)C(C)(C)C#N)C2CCC(C)(C)CC2)CN1C(=O)OC(C)(C)C>>CN(C)C(=O)[C@@H]1C[C@H](N(C(=O)C(C)(C)CN)C2CCC(C)(C)CC2)CN1C(=O)OC(C)(C)C,[Pd],CO,,[H][H],,val
US20130022629A1,COC(=O)Cl.Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1>>COC(=O)Nc1ccc(S(=O)(=O)Nc2nnc(C)s2)cc1,,c1ccncc1,,,,val
US20110166147A1,Cc1cnc(Cl)c2ncc(Br)n12.NCc1ccc(S(N)(=O)=O)cc1>>Cc1cnc(NCc2ccc(S(N)(=O)=O)cc2)c2ncc(Br)n12,,CC(C)CO,,CCN(C(C)C)C(C)C,Cl,val
US04535183,CCOC(=O)c1ccc(CBr)cc1.COCOc1cccc(O)c1C=O>>CCOC(=O)c1ccc(COc2cccc(O)c2C=O)cc1,,CS(C)=O,,O,CC(C)(C)[O-].[K+],val
US20060160801A1,CC(=O)CC(=O)OCCC#N.N#Cc1ccc(C=O)cc1.NC(=O)Nc1cccc(C(F)(F)F)c1>>CC1=C(C(=O)OCCC#N)C(c2ccc(C#N)cc2)NC(=O)N1c1cccc(C(F)(F)F)c1,,C1CCOC1,,,,val
US20040180934A1,COC(=O)CC1CCn2c1c(Sc1ccc(Cl)cc1)c1c(S(C)(=O)=O)cc(OC)cc12>>COc1cc(S(C)(=O)=O)c2c(Sc3ccc(Cl)cc3)c3n(c2c1)CCC3CC(=O)O,CC(=O)O,C1CCOC1,CO,[Li+].[OH-],,val
US20150023913A1,C[C@]1(CO)CCCCCO1.O=[Cr](=O)=O>>C[C@]1(C(=O)O)CCCCCO1,,CC(C)=O,CCOC(C)=O,O=S(=O)(O)O,,val
US20060014768A1,O=C1CC(=O)N(C2CC2)C(=O)N1c1ccc(I)cc1F.O=P(Cl)(Cl)Cl>>O=c1cc(Cl)n(-c2ccc(I)cc2F)c(=O)n1C1CC1,,O,,CN(C)c1ccccc1,,val
US20110081365A1,COCCl.OCc1cnc(Cl)c(Cl)c1>>COCOCc1cnc(Cl)c(Cl)c1,,ClCCl,,CCN(CC)CC,,val
US20030139475A1,CN(C)S(=O)(=O)Nc1cc(C(O)CNCCOc2ccc3c(c2)[nH]c2ccccc23)ccc1OCc1ccccc1.Cl>>CN(C)S(=O)(=O)Nc1cc(C(O)CNCCOc2ccc3c(c2)[nH]c2ccccc23)ccc1O.Cl,[Pd],CO,,CCOC(C)=O,,val
US20100204159A1,C=CCCCCCBr.C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)NS(=O)(=O)c1ccccc1N>>C=CCCCCCNc1ccccc1S(=O)(=O)NC(=O)[C@@]1(NC(=O)OC(C)(C)C)C[C@H]1C=C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120053216A1,CCO[C@@H]1[C@@H](OC)[C@H](C)O[C@@H](ON=Cc2ccc(-c3ncn(-c4ccc(OC(F)(F)C(F)(F)F)cc4)n3)cc2)[C@@H]1OC>>CCO[C@@H]1[C@@H](OC)[C@H](C)O[C@@H](ONCc2ccc(-c3ncn(-c4ccc(OC(F)(F)C(F)(F)F)cc4)n3)cc2)[C@@H]1OC,,CCO,O,Cl,O=C([O-])O.[Na+],val
US20080167310A1,CC(C)(C)OC(=O)C=Cc1ccc(O)cc1C=O.NO>>CC(C)(C)OC(=O)C=Cc1ccc(O)cc1C=NO,,CCO,,Cl,c1ccncc1,val
US05707997,COC(=O)CC(=O)CCC1(C)OCCO1.Nc1cc[nH]n1>>CC1(CCc2cc(O)n3nccc3n2)OCCO1,,Cc1ccccc1,,,,val
US20060223829A1,COC(=O)C1CCNCC1.O=S(=O)(Cl)c1cccc2ccccc12>>COC(=O)C1CCN(S(=O)(=O)c2cccc3ccccc23)CC1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20160060273A1,CCOc1cc(CN2CC3(CC([C@@H]4CC[C@@H](C(=O)OC)CC4)=NO3)C2)cc(OCC)c1-c1ccc(F)cc1>>CCOc1cc(CN2CC3(CC([C@@H]4CC[C@@H](C(=O)O)CC4)=NO3)C2)cc(OCC)c1-c1ccc(F)cc1,,CCO,,C1CCOC1,[Na+].[OH-],val
US20060020000A1,CCC[C@H]1CC[C@H](CCC)N1.COc1ccc2c(C(=O)C(C)(C)C)nn(CC(=O)O)c2c1>>CCC[C@H]1CC[C@H](CCC)N1C(=O)Cn1nc(C(=O)C(C)(C)C)c2ccc(OC)cc21,,CN(C)C=O,ClCCCl,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US20130035320A1,CC(=O)OCC(=O)[C@@]12CN(c3ccc4ccccc4n3)C[C@@H]1C[C@H]1[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C>>C[C@]12C=CC(=O)C=C1[C@@H](F)C[C@H]1[C@@H]3C[C@H]4CN(c5ccc6ccccc6n5)C[C@@]4(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F,,CO,,,,val
US04746352,COS(=O)(=O)OC.Cc1[nH]c(=O)n(-c2cc(C(=O)OC(C)C)c(Cl)cc2F)c(=O)c1C#N>>Cc1c(C#N)c(=O)n(-c2cc(C(=O)OC(C)C)c(Cl)cc2F)c(=O)n1C,,CN(C)C=O,,,,val
US20110160198A1,BrCCCc1ccccc1.COC(=O)[C@H](Cc1ccc(-c2ccc(C#N)cc2)cc1)NC(=O)[C@@H]1Cc2cc3c(cc2CN1)O[C@@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)CO3>>CCC(c1ccccc1)N1Cc2cc3c(cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(-c2ccc(C#N)cc2)cc1)C(=O)OC)OC[C@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)O3,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US06008230,CON(C)C(=O)c1cnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C>>CC(C)(C)[Si](OCc1c(C=O)cnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc12)(c1ccccc1)c1ccccc1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20050187272A1,CNCc1nc(-c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cs1.O=[N+]([O-])c1ccc(CBr)cc1>>CN(Cc1ccc([N+](=O)[O-])cc1)Cc1nc(-c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cs1,,ClCCl,,CCN(CC)CC,O,val
US20040077654A1,COc1ccc(Br)c(OC)c1.O=C1CCN(C(=O)OCc2ccccc2)CC1>>COc1ccc(C2(O)CCN(C(=O)OCc3ccccc3)CC2)c(OC)c1,,C1CCOC1,CCOC(C)=O,O,[Li]CCCC,val
US05334576,C#CC(C)(C)O.COC(=O)c1cc(Br)cnc1C1=NC(C)(C(C)C)C(=O)N1>>COC(=O)c1cc(C#CC(C)(C)O)cnc1C1=NC(C)(C(C)C)C(=O)N1,,CCN(CC)CC,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050192302A1,C=CC(=O)OC.ON=C(Cl)c1cccc(C(F)(F)F)c1>>COC(=O)C1CC(c2cccc(C(F)(F)F)c2)=NO1,,ClCCl,,,,val
US04686227,CC(=O)C(Cl)C(C)=O.Nc1nccc2c(Cl)cccc12>>CC(=O)c1c(C)nc2c3cccc(Cl)c3ccn12,,ClC(Cl)Cl,,,,val
US20110034469A1,CCO[C@@H]1C[C@@H](C(=O)NCc2ccccc2)N(C(=O)OC(C)(C)C)C1>>CCO[C@H]1CN[C@H](C(=O)NCc2ccccc2)C1,,CCOC(C)=O,,Cl,,val
US20100190688A1,CC(C(=O)NC(CCCCN)C(=O)N1CSCC1C(=O)NC1CCCc2ccccc21)N(C)C(=O)OC(C)(C)C.O=C(O)c1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)ON2C(=O)CCC2=O)c1>>CC(C(=O)NC(CCCCNC(=O)c1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1)C(=O)N1CSCC1C(=O)NC1CCCc2ccccc21)N(C)C(=O)OC(C)(C)C,,ClCCl,,,,val
US20090143444A1,CCOC(=O)CC#N.O=C(CBr)c1c(F)cccc1F>>CCOC(=O)C(C#N)CC(=O)c1c(F)cccc1F,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20110014271A1,O=C(O)CN(CC(=O)O)c1cccc(Oc2ccccc2)c1>>O=C1CN(c2cccc(Oc3ccccc3)c2)CC(=O)O1,,CC(=O)OC(C)=O,,O=C([O-])O.[Na+],,val
US20120010228A1,CC(C)(C)OC(=O)n1c(=O)n(CCCCl)c2cc(Cl)ccc21>>O=c1[nH]c2ccc(Cl)cc2n1CCCCl,,C1COCCO1,Cl,,,val
US05464831,NNS(=O)(=O)c1sccc1C1OCCCO1>>O=S1(=O)NN=Cc2ccsc21,,CC(C)=O,CCOC(C)=O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090221597A1,Nc1ccc(Br)nc1.O=C(O)C1(c2ccc3c(c2)OCO3)CC1>>O=C(Nc1ccc(Br)nc1)C1(c2ccc3c(c2)OCO3)CC1,CN(C)C=O,c1ccncc1,,O=S(Cl)Cl,,val
US20100135999A1,CCOC(=O)N1CCN(C(=O)CN(C)C(=O)OCc2ccccc2)CC1>>CCOC(=O)N1CCN(C(=O)CNC)CC1,[Pd],CCO,,,,val
US20100298336A1,BrCc1ccsc1.Cc1cc(O)nc(S)n1>>Cc1cc(O)nc(SCc2ccsc2)n1,,CCO,,CCN(CC)CC,,val
US05990105,C1CCNC1.Nc1ccc(S(=O)(=O)c2cc(Cl)nc(Cl)c2)cc1>>Nc1ccc(S(=O)(=O)c2cc(Cl)nc(N3CCCC3)c2)cc1,,C1COCCO1,,,,val
US20090156593A1,CC[Si](CC)(CC)c1[nH]c2cnccc2c1CCO>>OCCc1c[nH]c2cnccc12,O,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20020025957A1,CSC(SC)=C(C#N)C(=O)c1ccccc1Cl.Cc1cc2cc(N)ccc2o1.N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O>>Cc1cc2cc(NC(N[C@H]3CCCCN(CC(=O)N4CCCC4)C3=O)=C(C#N)C(=O)c3ccccc3Cl)ccc2o1,,CC#N,,CCN(CC)CC,Cl,val
US04471116,BrCCCOc1ccc(OCc2ccccc2)cc1.O=C1NC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1CCCOc1ccc(OCc2ccccc2)cc1,,CN(C)C=O,,[K],,val
US20090186900A1,CCOC(=O)CC1Cc2cc(-c3ccc(OCc4ccccc4)c(F)c3)ccc2C1=O>>CCOC(=O)CC1Cc2cc(-c3ccc(O)c(F)c3)ccc2C1=O,,ClCCl,,BrB(Br)Br,O,val
US20110178063A1,Brc1cncc2[nH]ccc12.CC(C)n1nccc1C(=O)Nc1cc(B2OC(C)(C)CC(C)(C)O2)cc2nn(C3CCCCO3)cc12>>CC(C)n1nccc1C(=O)Nc1cc(-c2cncc3[nH]ccc23)cc2[nH]ncc12,,C1COCCO1,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20050075483A1,CC(=O)C(=O)[C@H](O)[C@](O)(C(C)=O)[C@@](O)(C(C)=O)[C@H](O)C(O)C(C)=O.[N-]=[N+]=NCCCC(=O)Cl>>CC(=O)C(=O)[C@@](O)(C(=O)CCCN=[N+]=[N-])[C@](O)(C(C)=O)[C@@](O)(C(C)=O)[C@H](O)C(O)C(C)=O,,ClCCl,,c1ccncc1,O=C([O-])O.[Na+],val
US20060172973A1,CC(=O)c1cn(Cc2ccccc2)c(=O)[nH]c1=O.Fc1ccc(CBr)cc1>>CC(=O)c1cn(Cc2ccccc2)c(=O)n(Cc2ccc(F)cc2)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06825200B1,CC1CN(C(=O)OC(C)(C)C)CCN1c1ccc([N+](=O)[O-])cc1>>CC1CN(C(=O)OC(C)(C)C)CCN1c1ccc(N)cc1,[Fe],CCO,,[Cl-].[NH4+],,val
US04916148,Cc1ccc2ccc3c(c2c1)C(C)(C)C(=O)O3.O=C1CCC(=O)N1Br>>CC1(C)C(=O)Oc2ccc3ccc(CBr)cc3c21,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20030181456A1,CO[C@@H]1CNCC[C@@H]1CNC(=O)c1cc(Cl)cc2c1OCCO2.O=C(O)C(=O)O>>CO[C@@H]1CNCC[C@@H]1CNC(=O)c1cc(Cl)cc2c1OCCO2.O=C(O)C(=O)O,,CC(C)O,,,,val
US04006252,CC(C)(C)c1cc(C(Br)c2cc(C(C)(C)C)cc(C(C)(C)C)c2O)c(O)c(C(C)(C)C)c1>>CC(C)(C)C1=CC(=Cc2cc(C(C)(C)C)cc(C(C)(C)C)c2O)C(=O)C(C(C)(C)C)=C1,,CCO,,CC(=O)O,[Na+].[OH-],val
US20080090863A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@H](NC(=O)OCc2ccccc2)C1.Cl>>Cl.N[C@@H]1CC[C@H](NC(=O)OCc2ccccc2)C1,,CCOC(C)=O,,,,val
US20130331378A1,COC(=O)c1cccc(Cc2c(N3CCCCC3)nn3c([Si](C)(C)C)c(Cl)ccc23)n1>>COC(=O)c1cccc(Cc2c(N3CCCCC3)nn3cc(Cl)ccc23)n1,,C1CCOC1,,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20130109665A1,CNC(=O)[C@@H](N)C(C)(C)C.O=C(O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1>>CNC(=O)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140303153A1,COC(=O)c1c(CCl)cn(Cc2ccc(OC)cc2)c(=O)c1Cl.NCCc1ccc2ccccc2n1>>COc1ccc(Cn2cc3c(c(Cl)c2=O)C(=O)N(CCc2ccc4ccccc4n2)C3)cc1,,CCO,,,,val
US20030171581A1,C1COCCN1.N#Cc1ccc(S(=O)(=O)C(F)(F)F)cc1>>N#Cc1ccc(N2CCOCC2)cc1,,O,,,,val
US20130158003A1,C=CC(=O)OCC.Cc1cnc(C)c(Br)c1N>>CCOC(=O)/C=C/c1c(C)ncc(C)c1N,CC(=O)O[Pd]OC(C)=O,CN(C)C=O,O,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05395934,C1CNCCN1.Cn1ncc(Cl)c(Cl)c1=O>>Cn1ncc(N2CCNCC2)c(Cl)c1=O,,CCO,,,,val
US20020035110A1,Brc1cccc2c1C[C@@H]1CNCCN21.C=O.O=C1NCCO1>>O=C1OCCN1CN1CCN2c3cccc(Br)c3C[C@@H]2C1,,ClCCl,O,,,val
US20120270937A1,CCOC(=O)c1ccc(CBr)cc1CBr.O=S(=O)(O)O>>O=C1OCc2cc(CO)ccc21,,ClCCl,,C1COCCO1,,val
US20090023779A1,c1cc(OC2CCCCO2)ccc1Cc1noc2cc(OC3CCCCO3)ccc12>>Oc1ccc(Cc2noc3cc(O)ccc23)cc1,,CO,,O=C([O-])O.[Na+],,val
US04675324,CCC(=O)N1CCC(=O)c2cc(Cl)ccc21.CCOC=O>>CCC(=O)N1CC(=CO)C(=O)c2cc(Cl)ccc21,,O,,,,val
US20030166646A1,C=C(NC(C)=O)C(=O)OC.CN1CCNCC1>>COC(=O)C(CN1CCN(C)CC1)NC(C)=O,Cl[Fe](Cl)Cl,ClCCl,,O=S(=O)([O-])[O-].[Na+].[Na+],,val
US06103905,CC(C)(C)OC(=O)n1cc(-c2cc(C(=O)O)c3ccccc3n2)c2ccccc21>>O=C(O)c1cc(-c2c[nH]c3ccccc23)nc2ccccc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020137750A1,Cc1c(CO)cccc1NC(=N)c1cccs1.O=S(Cl)Cl>>Cc1c(CCl)cccc1NC(=N)c1cccs1.Cl,,ClCCl,,CCOCC,,val
US05002962,C=Cc1c(C)c2cc3nc(c4c5[nH]c(cc6nc(cc1[nH]2)C(C)=C6CC)c(C)c5C(=O)C4C(=O)OC)C(CCC(=O)OC)C3C.O>>C=Cc1c(C)c2cc3nc(c(CC(=O)O)c4[nH]c(cc5nc(cc1[nH]2)C(C)=C5CC)c(C)c4C(=O)O)[C@@H](CCC(=O)O)[C@@H]3C,,C1CCOC1,CO,[Na],C[O-].[Na+],val
US20080242654A1,CC(C)(C)c1cn(CC2(O)CCCCC2)c(=N)s1.COc1ccc(Cl)cc1C(=O)O>>COc1ccc(Cl)cc1C(=O)/N=c1\sc(C(C)(C)C)cn1CC1(O)CCCCC1,,C1CCOC1,,CCN(CC)CC,O=S(Cl)Cl,val
US20080287517A1,C=CCOc1c(NC(=O)c2nn(-c3ccc(Cl)cc3Cl)c(-c3ccc(O)cc3)c2C)ccc(F)c1F.O=S(=O)(Cl)CCC(F)(F)F>>C=CCOc1c(NC(=O)c2nn(-c3ccc(Cl)cc3Cl)c(-c3ccc(OS(=O)(=O)CCC(F)(F)F)cc3)c2C)ccc(F)c1F,,ClCCl,,O,,val
US20030139285A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccccc1Br>>O=S(=O)(Oc1ccccc1Br)C(F)(F)F,,ClCCl,,Cl,c1ccncc1,val
US20130143860A1,CCOC(=O)c1cccc(CBr)c1F.Oc1cnc(N2CCOCC2)nc1>>CCOC(=O)c1cccc(COc2cnc(N3CCOCC3)nc2)c1F,,C1CCOC1,CN(C)C=O,CC#N,O=C([O-])[O-].[K+].[K+],val
US20110212968A1,COc1ccc(C2OCC(C)(C)CO2)cc1SC>>COc1ccc(C=O)cc1SC,,CC(C)=O,,Cl,,val
US05877193,NC(N)=S.O=C(CBr)c1cccc(OCc2ccccc2)c1>>Br.Nc1nc(-c2cccc(OCc3ccccc3)c2)cs1,,CO,,,,val
US04788197,COc1ccc(C=O)cc1.c1ccc(C2=NCCN=C2c2ccccc2)cc1>>COc1ccc(Cc2cnc(-c3ccccc3)c(-c3ccccc3)n2)cc1,,CO,O,,,val
US04122179,CC[C@]12CCCN3CCc4c(n(c5ccccc45)[C@@](O)(C(=O)OC)C1)[C@@H]32.Oc1ccc(O)cc1>>CC[C@]12CCCN3CCc4c(n(c5ccccc45)[C@@](O)(C(=O)OC)C1)[C@@H]32.Oc1ccc(O)cc1,,O,,,,val
US20030125370A1,CN(C[C@@H]1CCCN1)C1CC1.Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)O>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@H]1CN(C)C1CC1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20030109527A1,CCNS(=O)(=O)c1c(Cl)ccc([N+](=O)[O-])c1O>>CCNS(=O)(=O)c1c(Cl)ccc(N)c1O,[Pd],,,[H][H],,val
US06320051B1,COc1ccc(CO)cc1.Clc1cc(Cl)c2ccccc2n1>>COc1ccc(COc2cc(Cl)nc3ccccc23)cc1,,C1CCOC1,,C1COCCOCCOCCOCCO1,[H-].[Na+],val
US20050090559A1,COc1c(F)cccc1C(C)(C)CC(O)(C=Nc1c(Cl)ccc2[nH]ncc12)C(F)(F)F>>COc1c(F)cccc1C(C)(C)CC(O)(CNc1c(Cl)ccc2[nH]ncc12)C(F)(F)F,,CO,,CC(=O)O,[BH4-].[Na+],val
US20070111998A1,COc1ccc(CN)c(OC)c1.c1ccc2c(c1)[nH]c1cccc(OC[C@@H]3CO3)c12>>COc1ccc(CNC[C@H](O)COc2cccc3[nH]c4ccccc4c23)c(OC)c1,,CC(C)O,CCOC(C)=O,,,val
US20120010212A1,CCOC(=O)C1(C)CN(Cc2ccccc2)CC1c1ccc(Cl)cc1>>CC1(CO)CN(Cc2ccccc2)CC1c1ccc(Cl)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160200725A1,CC(C)(O)CN.COc1cc(OC)c(Cl)c(-c2cc3cnc(S(C)(=O)=O)nc3n(CCOC3CCN(C(=O)OC(C)(C)C)CC3)c2=O)c1Cl>>COc1cc(OC)c(Cl)c(-c2cc3cnc(NCC(C)(C)O)nc3n(CCOC3CCN(C(=O)OC(C)(C)C)CC3)c2=O)c1Cl,,CC(C)(C)O,,,,val
US20120245344A1,CC(C)(C)OC(=O)N1C=CC(c2ccc(CO)nc2)=CC1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCC(c2ccc(COS(C)(=O)=O)nc2)CC1,,ClCCl,,CCN(CC)CC,O,val
US20110039836A1,COc1ccc2ccc(F)c(C(CO)CN3CCC(NC(=O)OC(C)(C)C)CC3)c2n1>>COc1ccc2ccc(F)c(C(CO)CN3CCC(N)CC3)c2n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20020068758A1,Cc1cc(=O)c(OCc2ccccc2)c(CO)o1>>Cc1cc(=O)c(OCc2ccccc2)c(C=O)o1,,ClC(Cl)Cl,,CCN(CC)CC,CS(C)=O,val
US04126689,COCC1(Nc2ccccc2)CCN(C(C)C)CC1.O=C(Cl)Cc1ccccc1>>COCC1(N(C(=O)Cc2ccccc2)c2ccccc2)CCN(C(C)C)CC1.Cl,,c1ccccc1,,,,val
US04072680,Nc1ccn[nH]1.O=C(Cl)c1cccnc1Cl>>O=C(Nc1ccn[nH]1)c1cccnc1Cl,,C1COCCO1,,CCN(CC)CC,,val
US20110028466A1,Brc1cnc(Br)cn1.CC1(CO)Cn2cc([N+](=O)[O-])nc2O1>>CC1(COc2cnc(Br)cn2)Cn2cc([N+](=O)[O-])nc2O1,,CN(C)C=O,,[H-].[Na+],,val
US20060211734A1,CC1CN(Cc2ccccc2)CCC1Oc1cccc(NC(=O)c2ccc(F)cc2Cl)c1.ClCCCl>>CC1CNCCC1Oc1cccc(NC(=O)c2ccc(F)cc2Cl)c1.Cl,,ClCCCl,,CC(Cl)OC(=O)Cl,,val
US20100113514A1,CC(C)(C)OC(=O)CBr.COc1cc2c(cc1-c1ccc(Cl)cc1)CCC(=O)N2>>COc1cc2c(cc1-c1ccc(Cl)cc1)CCC(=O)N2CC(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20090264445A1,CCOC(=O)/C=C(\CBr)Oc1cccc(F)c1.COC(=O)[C@@H](N)CC1CCCCC1>>COC(=O)[C@H](CC1CCCCC1)N1CC(Oc2cccc(F)c2)=CC1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20070072897A1,O=C1CCC(=O)N1Cl.OC[C@@H](O)[C@H](c1ccccc1)N1CCc2cccc(F)c21>>O[C@H](CCl)[C@H](c1ccccc1)N1CCc2cccc(F)c21,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040102634A1,CCOC(=O)C(Cc1ccc(OC)c(O)c1)OC(C)C.Cc1nc(-c2ccc(S(=O)(=O)Cl)s2)cs1>>COc1ccc(CC(OC(C)C)C(=O)O)cc1OS(=O)(=O)c1ccc(-c2csc(C)n2)s1,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US05484804,COc1ccccc1C1(O)C(O)CC(c2ccccc2)(c2ccccc2)C2CNCC21.COc1ccccc1CC(=O)Cl>>COc1ccccc1CC(=O)C1NCC2C1C(c1ccccc1)(c1ccccc1)CC(O)C2(O)c1ccccc1OC,,ClCCl,,CCN(CC)CC,Cl,val
US20110070317A1,Nc1c[nH]c2ncc(F)c(F)c12.O=C(Cl)c1cccnc1>>O=C(Nc1c[nH]c2ncc(F)c(F)c12)c1cccnc1,,c1ccncc1,,Cl,,val
US20130289027A1,COC(=O)C(OC(C)(C)C)c1c(-c2ccc(C)c(C)c2)c2ccc(C#N)cc2c(=O)n1C>>COC(=O)C(OC(C)(C)C)c1c(-c2ccc(C)c(C)c2)c2ccc(CN)cc2c(=O)n1C,[Ni],CCO,,N,,val
US20040186102A1,Cc1cc(Nc2cccc(-c3ccccc3C=O)c2)c2ccccc2n1.c1ccc2c(c1)CCNC2>>Cc1cc(Nc2cccc(-c3ccccc3CN3CCc4ccccc4C3)c2)c2ccccc2n1,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130072677A1,C#Cc1ccc(C=O)cc1.C1CNCCOC1>>C#Cc1ccc(CN2CCCOCC2)cc1,,CC(=O)O,ClC(Cl)Cl,Cl,O=C([O-])O.[Na+],val
US20040009995A1,CC(=O)N[C@H](C(=O)O)C(C)(C)S.CS(C)=O.CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2NC(=O)CBr)c1.O=C(O)C(F)(F)F>>CSc1sc(C(=N)N)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2NC(=O)[SH](C)C(C)(C)C(NC(C)=O)C(=O)O)c1.O=C(O)C(F)(F)F,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20050049236A1,COc1cc(OC)c(/C=C/C(=O)c2ccc(S(N)(=O)=O)cc2)cc1C#Cc1ccccc1N>>COc1cc(OC)c(-c2cc3ccccc3[nH]2)cc1/C=C/C(=O)c1ccc(S(N)(=O)=O)cc1,Cl[Pd]Cl,CC#N,,,,val
US20160009744A1,O=C1CCC(=O)N1Cl.OCc1cc(Br)cs1>>OCc1cc(Br)c(Cl)s1,,CN(C)C=O,,,,val
US05623005,Oc1cc(N2CCOCC2)c2ccccc2c1Cl>>Oc1cc(N2CCOCC2)c2ccccc2c1,[Pd],[K+],[OH-],[H][H],,val
US20110087032A1,CCOC(OCC)OCC.Cc1cc(C)c(N)c(C)c1.Nc1c(F)cccc1F>>Cc1cc(C)c(N=CNc2c(F)cccc2F)c(C)c1,CC(=O)O,,,,,val
US20090036469A1,CCOC(=O)C(C)(C)C1CCCN(C(=O)OCc2ccccc2)C1>>CC(C)(C(=O)O)C1CCCNC1,[Pd],CC(=O)O,,CO,,val
US04673746,COc1ccc(C(=O)c2ccc(Cl)cc2)c(O)c1.NO>>COc1ccc(/C(=N/O)c2ccc(Cl)cc2)c(O)c1,,c1ccncc1,,Cl,,val
US20100256156A1,Br[Mg]C1CCCCC1.CCc1sc(C2CCOCC2)cc1C=O>>CCc1sc(C2CCOCC2)cc1C(O)C1CCCCC1,,C1CCOC1,,[Cl-].[NH4+],,val
US20080161370A1,CCCCCCCN=C=O.O=c1[nH]c2ccccc2s1>>CCCCC(CC)C(N)=O.O=c1[nH]c2ccccc2s1,,C1COCCO1,,,,val
US04649146,CCOC(=O)c1nc(N)sc1-c1ccncc1>>Nc1nc(C(=O)O)c(-c2ccncc2)s1,,CO,O,[Na+].[OH-],,val
US20070112016A1,BrCCOC1CCCCO1.CC(C)(C)OC(=O)N1CCC(C(=O)Nc2ccccc2Br)CC1>>CC(C)(C)OC(=O)N1CCC(C(=O)N(CCOC2CCCCO2)c2ccccc2Br)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20100048564A1,Cc1ccc(F)c(Oc2ccc([N+](=O)[O-])c(CNC(=O)OC(C)(C)C)c2)c1>>Cc1ccc(F)c(Oc2ccc(N)c(CNC(=O)OC(C)(C)C)c2)c1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20100261728A1,FC(F)(F)c1ccc([C@H]2NCCc3ccccc32)cc1.O=C(Nc1ccccn1)Oc1ccc([N+](=O)[O-])cc1>>O=C(Nc1ccccn1)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1,,CC#N,,,,val
US05064953,O=C(Cl)c1ccco1.O=C(O)/C(=N\O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>O=C(O)/C(=N\OC(=O)c1ccco1)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,ClCCl,,CCN(CC)CC,Cl,val
US20140011800A1,C[C@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1O.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)O[C@H]2CN(C(=O)OCc3ccccc3)C[C@@H]2C)cc1,,c1ccncc1,,,,val
US20030207888A1,C1CCNC1.CC1CN(C(=O)OC(C)(C)C)CC2Cc3ccc(CO)nc3N12.CO.ClCCl.O.O=C(c1ncc[nH]1)c1ncc[nH]1>>CC(=O)[O-].C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(COC(=O)N4CCCC4)nc3N21.[NH4+],,CO,O,,,val
US20020111492A1,COC(=O)C1(CCC(O)c2c(Cl)cnc3ccc(OC)cc23)CCNCC1.Fc1cc(F)cc(OCCBr)c1>>COc1ccc2ncc(Cl)c(C3CCC4(CCN(CCOc5cc(F)cc(F)c5)CC4)C(=O)O3)c2c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060074087A1,CC1C(=O)C(C(O)/C=C/c2ccccc2)CCN1C(=O)OC(C)(C)C.O=[O+][O-]>>CC1C(=O)C(C(O)C=O)CCN1C(=O)OC(C)(C)C,,CO,ClCCl,,,val
US20110166139A1,CNC.Cn1cc([N+](=O)[O-])c(C(=O)O)n1>>CN(C)C(=O)c1nn(C)cc1[N+](=O)[O-],,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US05081304,CC(=O)OC(C)=O.CNC12CCCCC1Oc1ccccc12>>CC(=O)N(C)C12CCCCC1Oc1ccccc12,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US04456752,CC1CCC(Br)(Br)c2ncc(C(=O)O)c(=O)n21.NNc1ccccc1>>CC1CCC(=NNc2ccccc2)c2ncc(C(=O)O)c(=O)n21,,CS(C)=O,,CN(C)c1ccccc1,,val
US20040235867A1,Cn1c(=O)[nH]c2c(N)nccc21.N#Cc1cnc(Cl)s1>>Cn1c(=O)[nH]c2c(Nc3ncc(C#N)s3)nccc21,,C1CCOC1,,O,[H-].[Na+],val
US20080064676A1,CCOC(=O)CSCC1(c2ccc(Cl)cc2)OCC(C)(C)CO1>>CC1(C)COC(CSCC(=O)O)(c2ccc(Cl)cc2)OC1,,C1CCOC1,O,[Li+].[OH-],,val
US20020177723A1,COc1cc(C(O)CCC(O)c2cc(OC)c(OC)c(OC)c2)cc(I)c1OCCO>>COc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(I)c1OCCO,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20100234485A1,CCCC[Sn](CCCC)(CCCC)OC.O=C(c1ccccc1)c1ccc(CO)cc1>>CCCC[Sn](CCCC)(CCCC)OCc1ccc(C(=O)c2ccccc2)cc1,,ClCCCl,,,,val
US20120015962A1,COc1cc2nc(NCCO)ccc2cc1[N+](=O)[O-]>>COc1cc2nc(NCCO)ccc2cc1N,[Fe],CCO,CN(C)C=O,[Cl-].[NH4+],,val
US20130184253A1,CC(=O)N1CCN(C(=O)OC(C)(C)C)[C@H](C)C1.O=C(O)C(F)(F)F>>CC(=O)N1CCN[C@H](C)C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20060089350A1,NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl.c1ccc(CNCc2ccccc2)cc1>>NS(=O)(=O)c1cc(C(=O)N(Cc2ccccc2)Cc2ccccc2)c(NCc2ccco2)cc1Cl,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20120053166A1,O=S(=O)(c1ccccc1)n1ncc2c(-c3nnc(CCl)o3)cc(-c3cccc4[nH]ccc34)cc21.OCC1CCCCC1>>OCc1nnc(-c2cc(-c3cccc4[nH]ccc34)cc3[nH]ncc23)o1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20140329794A1,Nc1cccc(C(=O)NC[C@H](O)CN2CCc3ccccc3C2)c1.O=C1CCOCC1>>O=C(NC[C@H](O)CN1CCc2ccccc2C1)c1cccc(NC2CCOCC2)c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20150290339A1,C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N[N+](=O)[O-])NC(=O)CNC(=O)OC(C)(C)C)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)OCc1ccccc1>>C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N[N+](=O)[O-])NC(=O)CNC(=O)OC(C)(C)C)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O,,CO,,Cl,[Na+].[OH-],val
US20130274243A1,COC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C(=O)OCc1ccccc1>>CC(C(=O)OCc1ccccc1)[C@H](NC(=O)OC(C)(C)C)C(=O)O,,C1CCOC1,O,[Li+].[OH-],,val
US20060004069A1,CI.O=C1NC(=O)C(=Cc2ccc([N+](=O)[O-])cc2)S1>>CN1C(=O)SC(=Cc2ccc([N+](=O)[O-])cc2)C1=O,,O,,CN(C)C=O,[H-].[Na+],val
US20100004299A1,Cc1c(C#N)sc2nc(-c3ccc(F)cc3)cn12.NO>>Cc1c(C(=N)NO)sc2nc(-c3ccc(F)cc3)cn12,,CC(C)O,,CCN(CC)CC,Cl,val
US20120095022A1,CI.O=C1c2cccc([N+](=O)[O-])c2C2CC(O)CCN12>>COC1CCN2C(=O)c3cccc([N+](=O)[O-])c3C2C1,,C1CCOC1,,,,val
US20120252778A1,CCOC(OCC)c1cn(-c2ccc(Cc3c(CC)nn4c(C)cc(C)nc34)cc2)nn1>>CCc1nn2c(C)cc(C)nc2c1Cc1ccc(-n2cc(C=O)nn2)cc1,,C1COCCO1,,Cl,,val
US06329381B1,BrBr.CSc1nc(N)c2ncn(Cc3ccccc3)c2n1>>CSc1nc(N)c2nc(Br)n(Cc3ccccc3)c2n1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20150141471A1,Cc1nc(-c2ccc(C(F)(F)F)cc2)c(-c2ccc(Cl)cc2Cl)cc1C(=O)O>>Cc1nc(-c2ccc(C(F)(F)F)cc2)c(-c2ccc(Cl)cc2Cl)cc1CO,,C1CCOC1,,B,CO,val
US20050032871A1,Cc1[nH]c(C=O)c(CCC(=O)N(C)C)c1S(=O)(=O)c1cccc(C(=O)O)c1.O=C1Cc2ccccc2N1>>Cc1[nH]c(/C=C2\C(=O)Nc3ccccc32)c(CCC(=O)N(C)C)c1S(=O)(=O)c1cccc(C(=O)O)c1,,CCO,,C1CCNCC1,,val
US20110053943A1,Cc1ccccc1C1(CC(=O)O)CCNCC1.O=C(Cl)OC1C2CC3CC(C2)CC1C3>>Cc1ccccc1C1(CC(=O)O)CCN(C(=O)OC2C3CC4CC(C3)CC2C4)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US05102895,O=C(OO)c1cccc(Cl)c1.OCC=CCOCc1ccccc1>>OCC1OC1COCc1ccccc1,,ClCCl,,,,val
US20040254215A1,CCCCOC(=O)c1nc(O)c2cc(Br)ccc2c1O.O=P(Cl)(Cl)Cl>>CCCCOC(=O)c1nc(Cl)c2cc(Br)ccc2c1O,,CC#N,,,,val
US20030186978A1,N#Cc1ccc(Cn2c(N)nc(=O)c3c2ncn3Cc2ccc3ccccc3c2)cc1.[N-]=[N+]=[N-]>>Nc1nc(=O)c2c(ncn2Cc2ccc3ccccc3c2)n1Cc1ccc(-c2nnn[nH]2)cc1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20020025960A1,COC(=O)c1cc(I)ccc1N.CS(=O)(=O)Cl>>COC(=O)c1cc(I)ccc1NS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20070281934A1,COC(=O)c1ccc2c(C(C)=O)c[nH]c2c1>>CCc1c[nH]c2cc(C(=O)OC)ccc12,,C1CCOC1,,B,,val
US06703421B1,CC(C)(C)OC(=O)NC1Cc2ccc(C(=O)O)cc2C1.Nc1ccccc1>>CC(C)(C)OC(=O)NC1Cc2ccc(C(=O)Nc3ccccc3)cc2C1,,ClCCl,,CCN(CC)CC,CN(C)c1ccccn1,val
US05939448,O=C(CCl)c1ccc(F)cc1F.SCCOCc1ccccc1>>O=C(CSCCOCc1ccccc1)c1ccc(F)cc1F,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20090318456A1,CSc1nc(NCC(F)(F)F)c2nc(-c3ccc(F)cc3)cnc2n1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc(NCC(F)(F)F)c2nc(-c3ccc(F)cc3)cnc2n1,,ClCCl,,,,val
US20140128372A1,CC(C)(C)OC(=O)N1CCCC[C@H]1CN.Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)O)n2c1>>Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NC[C@@H]3CCCCN3)n2c1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160115158A1,COc1nc(Cl)ncc1NS(=O)(=O)Cc1cc(Cl)cc(Cl)c1>>O=S(=O)(Cc1cc(Cl)cc(Cl)c1)Nc1cnc(Cl)nc1O,,CO,ClCCl,BrB(Br)Br,,val
US20150158851A1,CCOC(=O)C(Cl)c1ccccc1.O=[N+]([O-])c1cn[nH]c1>>CCOC(=O)C(c1ccccc1)n1cc([N+](=O)[O-])cn1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05166206,CCCCc1nc(C)nc(C(=O)OC)c1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1>>CCCCc1nc(C)nc(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,CO,,CC(=O)O,[Na+].[OH-],val
US20020022616A1,CC1(C)C=Cc2c(ccc3[nH]c4c(c23)CCN(Cc2ccccc2)CC4)O1.Cl>>CC1(C)CCc2c(ccc3[nH]c4c(c23)CCNCC4)O1.Cl,[Pd],CCO,,,,val
US04146631,Nc1ccc(O)c(C(=O)O)c1.O=C(Cl)OCc1ccccc1>>O=C(Nc1ccc(O)c(C(=O)O)c1)OCc1ccccc1,,c1ccncc1,,Cl,,val
US20030055265A1,BrCc1ccccc1.Oc1cccc2occc12>>c1ccc(COc2cccc3occc23)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04916149,COC(=O)c1ccc2c(c1)nc(SCc1ccccc1)n2NC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1>>NS(=O)(=O)c1cc(C(=O)Nn2c(SCc3ccccc3)nc3cc(C(=O)O)ccc32)ccc1Cl,,[Na+],[OH-],,,val
US20140296203A1,C[C@@H](NC(=O)Nc1cc2c(cn1)cnn2C(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccc(F)cc1>>C[C@@H](NC(=O)Nc1cc2[nH]ncc2cn1)c1ccc(F)cc1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20040167194A1,Cc1c([N+](=O)[O-])cc(C(=O)O)c2nc[nH]c12.NS(N)(=O)=O>>Cc1c([N+](=O)[O-])cc(C#N)c2nc[nH]c12,,O=S1(=O)CCCC1,,O=P(Cl)(Cl)Cl,,val
US20030171428A1,CON(C)C(=O)c1cc(O)cc2cc(-c3ccc(O)cc3)oc12>>O=Cc1cc(O)cc2cc(-c3ccc(O)cc3)oc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030032665A1,Brc1ccc2c(c1)oc1ccccc12.O=S(=O)(O)Cl>>O=S(=O)(Cl)c1ccc2oc3cc(Br)ccc3c2c1,,ClC(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20130004423A1,CC(C)(C)OC(=O)CN1CCNCCN(CC(=O)OC(C)(C)C)CCN(CCc2ccc([N+](=O)[O-])cc2)CC1>>CC(C)(C)OC(=O)CN1CCNCCN(CC(=O)OC(C)(C)C)CCN(CCc2ccc(N)cc2)CC1,[Pd],CCO,,CCOCC,,val
US20060035897A1,Brc1ccc2cnncc2c1.Cc1ccc(C(=O)Nc2ccc(CN3CCCC3)c(C(F)(F)F)c2)cc1Br>>Cc1ccc(C(=O)Nc2ccc(CN3CCCC3)c(C(F)(F)F)c2)cc1-c1ccc2cnncc2c1,,CO,ClCCl,N,,val
US20040176388A1,COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)NCC2.Cc1cccc(-c2ccc(C(=O)O)c3ccccc23)n1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1ccc(-c3cccc(C)n3)c3ccccc13)CC2,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US04663329,CCOC(=O)c1cn(CC)c2sc(C=NO)cc2c1=O>>CCn1cc(C(=O)O)c(=O)c2cc(C=NO)sc21,,CN(C)C=O,,[Na+].[OH-],,val
US04935413,C=C(C)C(=O)N=C=O.O=C(c1ccccc1)c1ccc(O)cc1>>C=C(C)C(=O)NC(=O)Oc1ccc(C(=O)c2ccccc2)cc1,,ClCCCl,,ClC(Cl)Cl,,val
US20140135316A1,CC(=O)NN.COc1ccc2c(n1)NCC(C)C(=S)N2>>COc1ccc2c(n1)NCC(C)c1nnc(C)n1-2,,CCCCO,,,,val
US20010046993A1,O=C1CCC(=O)N1.OCCCN1CCN(Cc2ccccc2)CC1>>O=C1CCC(=O)N1CCCN1CCN(Cc2ccccc2)CC1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050192310A1,O=S(Cl)Cl.OCc1cnc(Cl)cc1Cl>>ClCc1cnc(Cl)cc1Cl,,ClCCl,,,,val
US20120258947A1,CCOC(=O)c1c(C)cc(N2CCOCC2)nc1N(C)CC.NCc1ccc(F)cc1>>CCN(C)c1nc(N2CCOCC2)cc(C)c1C(=O)NCc1ccc(F)cc1,,Cc1ccccc1,O,CCOC(C)=O,[Na+].[OH-],val
US05712225,C=O.NN(CCO)C(=S)Nc1ccc(Cl)cc1Cl>>S=C(Nc1ccc(Cl)cc1Cl)N1CCOCN1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060116383A1,CCOC(=O)CC(c1ccccc1)n1cnc2ccc(N)cc21.O=C(Cl)c1ccccc1[N+](=O)[O-]>>CCOC(=O)CC(c1ccccc1)n1cnc2ccc(NC(=O)c3ccccc3[N+](=O)[O-])cc21,,ClCCl,,CCN(CC)CC,,val
US20010041674A1,COc1cc(CCl)cc(OC)c1.S[C@@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1>>COc1cc(CS[C@@H]2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)cc(OC)c1,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20070105890A1,CCOC(=O)c1ccc2c3nc(N4CCC[C@@H](N)C4)n(Cc4ccccc4Cl)c3c(=O)n(C)c2c1OC.Cl>>Cl.Cn1c(=O)c2c(nc(N3CCC[C@@H](N)C3)n2Cc2ccccc2Cl)c2ccc(C(=O)O)c(O)c21,,Cl,,,,val
US04226775,COC(=O)[C@@H]1CCCN1.O=C(O)CCC(=O)c1ccccc1>>COC(=O)[C@@H]1CCCN1C(=O)CCC(=O)c1ccccc1,,C1CCOC1,,Cl,O=C(n1ccnc1)n1ccnc1,val
US20100298316A1,C1CCC(N2CCNCC2)C1.Clc1nc2ccc(Br)cc2s1>>Brc1ccc2nc(N3CCN(C4CCCC4)CC3)sc2c1,,CCO,,CCN(CC)CC,,val
US20080125468A1,C1CCOC1.CON(C)C(=O)c1cnc(-c2ccc(C(F)(F)F)cc2)nc1>>CCCCCCC(=O)c1cnc(-c2ccc(C(F)(F)F)cc2)nc1,,C1CCOC1,,,,val
US20120238599A1,C=COCCONC(=O)c1c(OC)c(C)c(=O)n(C)c1Nc1ccc(I)cc1F>>COc1c(C(=O)NOCCO)c(Nc2ccc(I)cc2F)n(C)c(=O)c1C,,CO,,Cl,,val
US20160200695A1,Nc1nc2ccccc2[nH]1.O=C(O)c1ccc(C(=O)c2ccccc2)cc1>>O=C(Nc1nc2ccccc2[nH]1)c1ccc(C(=O)c2ccccc2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120258952A1,CCc1nn(Cc2cnn(CCO[Si](C)(C)C(C)(C)C)c2)c2cccc(NC(=O)c3cnc4ccccn34)c12>>CCc1nn(Cc2cnn(CCO)c2)c2cccc(NC(=O)c3cnc4ccccn34)c12,Cl,CO,,,,val
US20070060607A1,CCOC(=O)c1cnc(Cl)c2c(COc3cc(NC(=O)c4ccccc4)ccc3C)csc12.N>>CCOC(=O)c1cnc(N)c2c(COc3cc(NC(=O)c4ccccc4)ccc3C)csc12,,CC(C)O,,,,val
US20140221356A1,N#Cc1ccc(F)cc1OC1CC1>>NCc1ccc(F)cc1OC1CC1,,CCOCC,,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US04152432,CC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOC(C)C)c3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)[C@H]2SC1.O>>OC(c1ccccc1)(c1ccccc1)c1ccccc1,,O,,O=CO,,val
US20110098320A1,C[C@@H](c1ccc(Br)cc1)N1CC[C@](CCCO)(c2ccc(F)cc2)CC1=O.O=[Cr](=O)=O>>C[C@@H](c1ccc(Br)cc1)N1CC[C@](CCC(=O)O)(c2ccc(F)cc2)CC1=O,,CC(C)=O,CCOC(C)=O,O=S(=O)(O)O,,val
US20070179164A1,COc1cccc(C=O)c1O.COc1cccc(OC)c1-n1c(C)nc2ccccc2c1=O>>COc1cccc(/C=C/c2nc3ccccc3c(=O)n2-c2c(OC)cccc2OC)c1O,,CC(=O)O,,,,val
US04908394,CC(C)CO.O=C(O)c1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>CC(C)COC(=O)c1ccc(N)cc1N,,Cc1ccccc1,,O=S(=O)(O)O,,val
US20120295903A1,CCCCCCN.Cc1cc(Br)c([N+](=O)[O-])cc1C>>CCCCCCNc1cc(C)c(C)cc1[N+](=O)[O-],,ClCCl,,,,val
US20140128390A1,COc1cccc([C@H](C)N=C=O)c1.Cc1nn(C)cc1-c1cc2ncnc(C3=CCNCC3)c2s1>>COc1cccc([C@H](C)NC(=O)N2CC=C(c3ncnc4cc(-c5cn(C)nc5C)sc34)CC2)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20100087471A1,Cl.NNc1ccc(Br)cc1.O=C1CCN2CCC1CC2>>Brc1ccc2[nH]c3c(c2c1)CN1CCC3CC1.Cl,,CC(=O)O,,Cl,,val
US20130345258A1,CCOC(=O)c1[nH]nc(Nc2ccnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cc23)c1C>>COc1cc2nccc(Nc3n[nH]c(CO)c3C)c2cc1S(=O)(=O)C(C)(C)C,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20130190377A1,C=C(C)C(=O)OC1(C)C(c2ccccc2)CC(=O)N1C(=O)C(=C)C>>C=C(C)C(=O)N1C(=C)C(c2ccccc2)CC1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060199800A1,CC#CCOc1ncnc(Cl)c1F.CC1CCCCN1>>CC#CCOc1ncnc(N2CCCCC2C)c1F,,CCO,,,,val
US20120083475A1,CC1(C)OC(=O)C2(CC2)C(=O)O1.Cn1ccc(N)n1>>Cn1ccc(N2CCC(C(=O)O)C2=O)n1,,CCO,,,,val
US20060235029A1,CCN(CC)CCCNc1nc(-c2cccc(C(=O)O)c2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1.NC1CC1>>CCN(CC)CCCNc1nc(-c2cccc(C(=O)NC3CC3)c2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070259924A1,NCCO.O=C(NCc1cn(-c2ccc(-n3ccccc3=O)cc2F)cn1)c1ccc(Cl)s1>>O=C(NCc1cn(-c2ccc(-n3ccccc3=O)cc2NCCO)cn1)c1ccc(Cl)s1,,CS(C)=O,,,,val
US20040147543A1,CS(=O)(=O)NCCNc1c([N+](=O)[O-])cnc2cc(Br)ccc12>>CS(=O)(=O)NCCNc1c(N)cnc2cc(Br)ccc12,[Pt],CC#N,,,,val
US04223033,BrP(Br)Br.OCc1cccc(Oc2ccccc2)n1>>BrCc1cccc(Oc2ccccc2)n1,,CCOCC,,,,val
US07087644B1,CCOC(=O)CCCCN(CCc1ccccc1OCc1ccc(Br)cc1)COC(=O)c1ccccc1.COCCOC.OB(O)c1ccc(Cl)cc1>>CCOC(=O)CCCCN(CCc1ccccc1OCc1ccc(-c2ccc(Cl)cc2)cc1)Cc1ccc(C(=O)OC)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20110144081A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN[C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccc(Cl)c(Cl)c1>>CN(C(=O)OC(C)(C)C)[C@H]1CN(Cc2ccccc2)C[C@@H]1c1ccc(Cl)c(Cl)c1,CN(C)c1ccncc1,ClCCl,O,CCN(CC)CC,,val
US20160176848A1,C=CCBr.COC(=O)c1cc(-c2cc3c(cc2C(=O)N2Cc4ccccc4C[C@H]2C)OCO3)n2c1CC(O)CC2>>C=CCOC1CCn2c(-c3cc4c(cc3C(=O)N3Cc5ccccc5C[C@H]3C)OCO4)cc(C(=O)OC)c2C1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20140199263A1,Nc1cccc(F)c1N.O=C(O)c1ccnc(Cl)c1>>Fc1cccc2nc(-c3ccnc(Cl)c3)[nH]c12,,O,,[Na+].[OH-],,val
US20040122016A1,CNc1ccccc1.O=C(CCl)Nc1nc(-c2ccncc2)cs1>>CN(CC(=O)Nc1nc(-c2ccncc2)cs1)c1ccccc1,,CC(=O)N(C)C,,,,val
US20040010007A1,COc1ccc(CNCc2ccc(OC)cc2)cc1.Cc1c(Cl)nc(OS(=O)(=O)C(F)(F)F)c([N+](=O)[O-])c1NCCOCCNC(=O)OC(C)(C)C>>COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(Cl)c(C)c(NCCOCCNC(=O)OC(C)(C)C)c2[N+](=O)[O-])cc1,,Cc1ccccc1,,CCN(CC)CC,CCOCC,val
US20060063767A1,N#Cc1ccnc(C=C2OC(=O)c3ccccc32)c1.NN>>N#Cc1ccnc(Cc2n[nH]c(=O)c3ccccc23)c1,,O,,,,val
US20040048885A1,CCOC(=O)C(Cl)C(C)=O.Nc1ncccc1OCC1(c2ccccc2)CC1>>CCOC(=O)c1c(C)nc2c(OCC3(c4ccccc4)CC3)cccn12,,CCOC(C)=O,CO,,,val
US03950528,CCOC(=O)C=C(N)OCC.Cc1ccccc1CNN>>Cc1ccccc1Cn1[nH]c(N)cc1=O,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20040023945A1,CC1(C)OC[C@@H](C(=O)Cl)O1.COc1ccc(C2CNCC2(C)C(C)O)cc1O>>COc1ccc([C@@H]2CN(C(=O)[C@H]3COC(C)(C)O3)C[C@@]2(C)[C@@H](C)O)cc1O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05006522,C#CCN1c2ccccc2C(=O)Nc2cccnc21.C1CCNC1.C=O>>O=C1Nc2cccnc2N(CC#CCN2CCCC2)c2ccccc21,Cl[Cu],C1COCCO1,,C,,val
US20100317865A1,CC(C)(C)OC(=O)C(C)(C)NCCc1ccc(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)cc1>>CC(C)(NCCc1ccc(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)cc1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04367089,CC(C)(C)C(O)C(Oc1ccc(Cl)cc1)n1cncn1.O=C(Cl)Cl>>CC(C)(C)C(OC(=O)Cl)C(Oc1ccc(Cl)cc1)N1CN=CN1,,C1CCOC1,,c1ccncc1,,val
US20050209229A1,COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1.CS(C)=O>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1.CS(C)=O,,CCOC(C)=O,,,,val
US05668291,CC(C)CC(NC(=O)c1cc(F)ccc1SSc1ccc(F)cc1C(=O)NC(CC(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>CC(C)CC(NC(=O)c1cc(F)ccc1SSc1ccc(F)cc1C(=O)NC(CC(C)C)C(=O)O)C(=O)O,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US05593969,CCCCCCCCCCCCBr.[O-]P(OCc1ccccc1)OCc1ccccc1>>CCCCCCCCCCCCP(=O)(OCc1ccccc1)OCc1ccccc1,,C1CCOC1,CN(C)C=O,Cl,CC(C)(C)[O-].[K+],val
US20090291938A1,C=CCC1CN(C2CCCC2)c2nc(Cl)ncc2N(C)C1=O.COc1cc(C(=O)O)ccc1N>>C#CCC1CN(C2CCCC2)c2nc(Nc3ccc(C(=O)O)cc3OC)ncc2N(C)C1=O,,C1COCCO1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20150119362A1,O=[N+]([O-])c1ccc(Cn2cc(Cl)cn2)cc1>>Nc1ccc(Cn2cc(Cl)cn2)cc1,[Pt],CCOC(C)=O,,,,val
US20100120764A1,CN(C(=O)c1ccc2nonc2c1)C1CCNCC1.CS(=O)(=O)Cl>>CN(C(=O)c1ccc2nonc2c1)C1CCN(S(C)(=O)=O)CC1,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US20160122318A1,CC(C)C1NC(=O)c2cc(Cl)ccc21.FC(F)(F)c1ccc(CBr)cc1>>CC(C)C1c2ccc(Cl)cc2C(=O)N1Cc1ccc(C(F)(F)F)cc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20120165310A1,O=C(NC1CC(CN2CCS(=O)(=O)CC2)C1)OCc1ccccc1>>N[C@H]1C[C@@H](CN2CCS(=O)(=O)CC2)C1,[Pd],CCO,,,,val
US20160221945A1,CC(C)(C)OC(=O)N1CC[C@H](F)[C@H]1C(=O)Nc1cc(F)cc(-c2cnc(C(F)(F)F)cn2)c1.Cl>>Cl.O=C(Nc1cc(F)cc(-c2cnc(C(F)(F)F)cn2)c1)[C@H]1NCC[C@@H]1F,,C1COCCO1,,,,val
US20120083513A1,C#CCN.Cn1nnc2c(C(=N)SCC(=O)C(=O)O)ncn2c1=O>>C#CCNC(=O)c1csc(-c2ncn3c(=O)n(C)nnc23)n1,,C1CCOC1,,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20080139631A1,O=C(Cl)c1cc(F)ccc1F.[H]/N=C(/Cn1c(CCC)cc2c(C(F)(F)F)c(C#N)ccc21)NO>>CCCc1cc2c(C(F)(F)F)c(C#N)ccc2n1Cc1noc(-c2cc(F)ccc2F)n1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20160046597A1,Cn1cc(C2CCCNC2)c2cc(NC(=O)c3cc(C#N)ccn3)ccc21.O=C(O)c1cc[nH]n1>>Cn1cc(C2CCCN(C(=O)c3cn[nH]c3)C2)c2cc(NC(=O)c3cc(C#N)ccn3)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060183754A1,Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1NC(=O)CCCc1ccc(OC(C)(C)C(=O)OC(C)(C)C)cc1>>Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1NC(=O)CCCc1ccc(OC(C)(C)C(=O)O)cc1,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20100279969A1,CC(C)C(=O)Nc1nc2c(ncn2[C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]1.O=C(OC(=O)c1ccccc1)c1ccccc1>>CC(C)C(=O)Nc1nc2c(ncn2[C@H]2C[C@H](O)[C@@H](COC(=O)c3ccccc3)O2)c(=O)[nH]1,CN(C)c1ccncc1,CN(C)C=O,,CCN(CC)CC,,val
US20030087925A1,CC(C)(CC(=O)O)NCc1ccccc1>>CC(C)(CCO)NCc1ccccc1,,C1CCOC1,,B,,val
US05254558,CC(C)C(NC(=O)Cn1c(-c2ccc(F)cc2)ncc(NC(=O)OCc2ccncc2)c1=O)C(O[Si](C)(C)C(C)(C)C)C(F)(F)F>>CC(C)C(NC(=O)Cn1c(-c2ccc(F)cc2)ncc(NC(=O)OCc2ccncc2)c1=O)C(O)C(F)(F)F,,ClCCl,,CO,,val
US20030008849A1,CC#CCOc1ccc(S(=O)(=O)N[C@@H](C(=O)OC)c2ccc(OCCN)cc2)cc1.CC(=O)OC(C)=O>>CC#CCOc1ccc(S(=O)(=O)N[C@@H](C(=O)OC)c2ccc(OCCNC(C)=O)cc2)cc1,,c1ccncc1,,,,val
US20150336901A1,CO[C@H]1CCC[C@@H](Nc2nc(SC)ncc2C(=O)O)C1.[NH4+]>>CO[C@H]1CCC[C@@H](Nc2nc(SC)ncc2C(N)=O)C1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cc1cc(N2CCN(C)CC2)ccc1N>>COc1ccc2nc(Nc3ccc(N4CCN(C)CC4)cc3C)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US20150152118A1,CC(C)(C)OC(=O)N1CCN(c2ccc(F)cc2)C(=O)C1.Cl>>Cl.O=C1CNCCN1c1ccc(F)cc1,,ClCCl,,C1COCCO1,,val
US20100069629A1,C1CCOC1.CN1CCN(c2cc(N)ccn2)CC1.COc1cccc(-c2nc(N3CCOCC3)nc(Cl)c2CCCl)c1>>COc1cccc(-c2nc(N3CCOCC3)nc3c2CCN3c2ccnc(OCCN(C)C)c2)c1,,C1CCOC1,,[H-].[Na+],,val
US20090118499A1,Cc1cc(-c2ccccc2)nc2cc(B3OC(C)(C)C(C)(C)O3)ccc12.Nc1nccn2c(C3CCC(CO)CC3)nc(I)c12>>Cc1cc(-c2ccccc2)nc2cc(-c3nc([C@@H]4CC[C@@H](CO)CC4)n4ccnc(N)c34)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050165014A1,CC(=O)CC(C)=O.CCOC(=O)/C=C(\C)Nc1cccc(C)c1.N#Cc1ccc(C=O)cc1>>CCOC(=O)C1=C(C)N(c2cccc(C)c2)C(C)=C(C(C)=O)C1c1ccc(C#N)cc1,,CC(C)OC(C)C,,O=C(O)C(F)(F)F,,val
US20090075979A1,CCOC(=O)C[C@@H]1CC[C@@H](C(=O)O)CC1>>CCOC(=O)C[C@@H]1CC[C@@H](CO)CC1,,C1CCOC1,,,,val
US20110212918A1,COc1ccc(S(=O)(=O)O)c(C(=O)O)c1>>COc1ccc2c(c1)C(=O)OS2(=O)=O,,c1ccccc1,,O=S(Cl)Cl,,val
US20080242663A1,BrC(Br)(Br)Br.O=[N+]([O-])c1cc(CO)cc(N2CCOCC2)c1>>O=[N+]([O-])c1cc(CBr)cc(N2CCOCC2)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040143115A1,CC(C)(C)OC(=O)N1CCCC[C@H]1CNc1cnc2cc(F)c(F)cc2n1>>Fc1cc2ncc(NC[C@@H]3CCCCN3)nc2cc1F,,O=C(O)C(F)(F)F,,,,val
US20060089367A1,Fc1cc2nc(COc3ccccc3)n(Cc3ccc(Cl)cc3)c2cc1N1CCNCC1.O=C(Cl)c1ccccc1>>O=C(c1ccccc1)N1CCN(c2cc3c(cc2F)nc(COc2ccccc2)n3Cc2ccc(Cl)cc2)CC1,,ClCCl,,,,val
US05872118,O=C(O)CC(CC(=O)O)c1cc(F)cc(F)c1>>O=C(O)CC1CC(=O)c2c(F)cc(F)cc21,,CO,ClCCl,,,val
US20110152322A1,CCC1CC1N.N#CC=C(Cl)c1cccnc1Cl>>CCC1CC1NC(=CC#N)c1cccnc1Cl,,CC#N,,CCN(CC)CC,Cl,val
US20100216860A1,COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2C(=O)OC(C)(C)C>>COc1cccc2[nH]nc(NS(=O)(=O)c3ccc(Cl)s3)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120190665A1,COc1ncc(Cl)cc1-c1c(NC(=O)OC(C)(C)C)cnn1COCC[Si](C)(C)C>>COc1ncc(Cl)cc1-c1[nH]ncc1N,,CCOC(C)=O,,Cl[Sn](Cl)(Cl)Cl,,val
US05580872,C1CC(C2CCNCC2)CCN1.CCOC(=O)c1cc(C2CC2)c2c(C)c(Cl)c(F)cn2c1=O.O=C(O)C(F)(F)F>>Cc1c(N2CCC(N3CCCCC3)CC2)c(F)cn2c(=O)c(C(=O)O)cc(C3CC3)c12.O=C(O)C(F)(F)F,,CC#N,,,,val
US20160244410A1,COc1ccc(Cn2c(=O)c3c(OS(=O)(=O)C(F)(F)F)cc(=O)n(C)c3n(-c3ccc(I)cc3F)c2=O)cc1.Cc1ccncc1O>>COc1ccc(Cn2c(=O)c3c(Oc4cnccc4C)cc(=O)n(C)c3n(-c3ccc(I)cc3F)c2=O)cc1,,C1CCOC1,,[H-].[Na+],,val
US20150038438A1,C=C(C)COc1cc2c(cc1Br)cc(CO[Si](C)(C)C(C)(C)C)n2C.CN(C)C=O>>C=C(C)COc1cc2c(cc1C=O)cc(CO[Si](C)(C)C(C)(C)C)n2C,,C1CCOC1,,[Li]CCCC,,val
US20090137580A1,Cn1ccc2ncnc(Cl)c21.O=C(O)c1cccc(O)c1>>Cn1ccc2ncnc(Oc3cccc(C(=O)O)c3)c21,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050159605A1,O=C1Nc2cccc(CCN3C(=O)c4ccccc4C3=O)c2C1Cl>>O=C1Cc2c(CCN3C(=O)c4ccccc4C3=O)cccc2N1,[Pd],CN(C)C=O,,CCN(CC)CC,,val
US20110105491A1,COC(=O)c1nc(N(C)C)sc1-c1cccc(C)c1>>Cc1cccc(-c2sc(N(C)C)nc2C(=O)O)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20110183960A1,CC(C)(C)OC(=O)N1CCC(N)(C(N)=O)CC1.O=CCC(F)(F)F>>CC(C)(C)OC(=O)N1CCC(NCCC(F)(F)F)(C(N)=O)CC1,,ClCCl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060106029A1,C[Si](C)(C)CCOCn1ccc(Nc2cncc(CN3CCN(C(=O)c4cccc(C(F)(F)F)c4F)CC3)n2)n1>>O=C(c1cccc(C(F)(F)F)c1F)N1CCN(Cc2cncc(Nc3cc[nH]n3)n2)CC1,,O=C(O)C(F)(F)F,,O,,val
US20080085886A1,CCN(C(C)C)C(C)C.NOCCC1CCOCC1.O=C(O)c1oc2ccncc2c1Nc1ccc(I)cc1F>>O=C(NOCCN1CCOCC1)c1oc2ccncc2c1Nc1ccc(I)cc1F,,C1CCOC1,,On1nnc2ccccc21,,val
US05182263,Brc1ccc(-c2nn[nH]n2)cc1.CC(C)(C)O>>CC(C)(C)n1nnc(-c2ccc(Br)cc2)n1,,O=C(O)C(F)(F)F,,O=S(=O)(O)O,,val
US20040023973A1,CN(C)CCCl.O=c1c(-c2ccccc2Cl)cc(-c2ccccn2)cn1-c1ccc(O)cc1>>CN(C)CCOc1ccc(-n2cc(-c3ccccn3)cc(-c3ccccc3Cl)c2=O)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04155996,CCOP(=S)(Cl)OCC.COC(=O)c1cc(O)c(C(=O)OC)s1>>CCOP(=S)(OCC)Oc1cc(C(=O)OC)sc1C(=O)OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05959107,Nc1ccc(F)c([N+](=O)[O-])c1.Sc1cccc2cnccc12>>Nc1ccc(Sc2cccc3cnccc23)c([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110306599A1,O=C(CBr)OCc1ccccc1.O=C1CCCCN1>>O=C(CN1CCCCC1=O)OCc1ccccc1,,CN(C)C=O,O,CCOC(C)=O,[H-].[Na+],val
US20110021490A1,COC(=O)c1ccccc1C(=O)OC>>COC(=O)c1ccccc1C(=O)O,,CCO,,[Na+].[OH-],,val
US20010047001A1,Cc1ccc(CO)cc1.Cc1cccc(C)c1NC(=O)CN1CCN(CC(O)COC2Cc3ccccc3C2)CC1>>Cc1ccc(COCC(O)CN2CCN(CC(=O)Nc3c(C)cccc3C)CC2)cc1,,CC(C)O,,,,val
US20100144760A1,Cc1ccc(-c2ncccn2)nc1.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(-c2ncccn2)[n+]([O-])c1,,ClCCl,,,,val
US20090253875A1,CC[Si](Cl)(Cl)CC.COc1c(Br)cc(C)cc1C(C)(C)C>>COc1c(C(C)(C)C)cc(C)cc1[Si](C)(C)Cl,,CCOCC,,CCCCCC,[Li]CCCC,val
US04868177,C1CCNC1.Nc1c2c(nc3ccccc13)CCCC2O>>Nc1c2c(nc3ccccc13)CCCC2N1CCCC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20030139435A1,CNC(=O)c1ccc(C)c(Nc2cc(F)nc(N[C@@H]3CCN(C(=O)OC(C)(C)C)C3)n2)c1.CNCC(C)(C)C>>CNC(=O)c1ccc(C)c(Nc2cc(N(C)CC(C)(C)C)nc(N[C@@H]3CCN(C(=O)OC(C)(C)C)C3)n2)c1,,C1COCCO1,,CCN(C(C)C)C(C)C,Cl,val
US20060041128A1,BrCc1ccccc1.Cc1noc2nc(CC(C)C)[nH]c(=O)c12>>Cc1noc2nc(CC(C)C)n(Cc3ccccc3)c(=O)c12,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090042852A1,CCc1cnc(-c2cc(Cl)c(N3CCC(C(=O)OC)CC3)nc2N=[N+]=[N-])o1>>CCc1cnc(-c2cc(Cl)c(N3CCC(C(=O)O)CC3)nc2N=[N+]=[N-])o1,,CO,,Cl,[Na+].[OH-],val
US20130345191A1,Clc1nnc(Cl)c(Cl)n1.NCc1cccc(F)c1F>>Fc1cccc(CNc2nc(Cl)nnc2Cl)c1F,,CCOC(C)=O,CN1CCCC1=O,CCN(C(C)C)C(C)C,,val
US05302592,CC(=O)/C=C\SC#N.Cn1nnnc1S>>CC(=O)/C=C\N1NN=C(S)N1C,,CCO,,O,[Na],val
US20140171408A1,CCOC(=O)c1csc(-c2c(F)cccc2Cl)n1>>OCc1csc(-c2c(F)cccc2Cl)n1,,CO,,[BH4-].[Li+],,val
US04753953,CCn1cc(C(=O)O)c(=O)c2cc(F)c(Cl)cc21.C[C@H]1CNC[C@H]1NC(=O)OC(C)(C)C>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3C[C@@H](N)[C@@H](C)C3)cc21,,CC#N,,C1CCC2=NCCCN2CC1,,val
US08389527B2,N[C@@H]1CC[C@@H](Nc2cc(Nc3cccc(Br)n3)c3ncc(C(=O)Nc4ccncc4F)n3n2)CC1.N[C@H]1CC[C@H](O)CC1>>N[C@@H]1CC[C@@H](Nc2cc(Nc3cccc(N[C@@H]4CC[C@@H](O)CC4)n3)c3ncc(C(=O)Nc4ccncc4F)n3n2)CC1,,CN1CCCC1=O,,CO,,val
US20060166990A1,Cc1ccc(OCC2COC(C)(C)O2)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1[N+](=O)[O-]>>Cc1ccc(OCC(O)CO)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1[N+](=O)[O-],,O,O=C(O)C(F)(F)F,,,val
US20130225679A1,CC(C)(C)C(=O)Cl.CN(C)CC1CCC2CC2C1(O)c1cc(O)cc(F)c1>>CN(C)CC1CCC2CC2C1(O)c1cc(F)cc(OC(=O)C(C)(C)C)c1,,ClCCl,,CCN(CC)CC,,val
US20080306082A1,CC(C)(C)OC(=O)N1CCN(CCCN)CC1.Cc1cnc(Cl)nc1-c1cc2ccccc2s1>>Cc1cnc(C(N)CCN2CCN(C(=O)OC(C)(C)C)CC2)nc1-c1cc2ccccc2s1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US04272441,CN.O=C(Cl)Cl.Oc1cccc2ccccc12>>CNC(=O)Oc1cccc2ccccc12,,Cc1ccccc1,,,,val
US20090018103A1,COCCCO[C@@H](c1ccccc1)[C@@H]1CCCN(C(=O)Cl)C1.C[Si](C)(C)CCOC(=O)NC[C@@H](N)CC1CCCCC1>>COCCCO[C@@H](c1ccccc1)[C@@H]1CCCN(C(=O)N[C@H](CNC(=O)OCC[Si](C)(C)C)CC2CCCCC2)C1,,ClCCl,,CCN(CC)CC,,val
US20150239866A1,C=C(C)Cn1cc(-c2cc(C)cc(Nc3nccc(C)n3)c2)nn1.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>Cc1cc(Nc2nccc(C)n2)cc(-c2cn(CC(C)(O)CO)nn2)c1,O=[Os](=O)(=O)=O,,,C1CCOC1,O,val
US20150225422A1,CCc1cc(N)ncc1Br.O=[N+]([O-])O>>CCc1c(Br)cnc(N)c1[N+](=O)[O-],,O=S(=O)(O)O,,O,[Na+].[OH-],val
US20160137637A1,Nc1nnc(N2CCOCC2)s1.O=C(O)c1csc(-c2ccc3c(c2)CCO3)n1>>O=C(Nc1nnc(N2CCOCC2)s1)c1csc(-c2ccc3c(c2)CCO3)n1,,c1ccncc1,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US04556655,C=[N+]=[N-].CC(C)(C)OC(=O)NCC#CC[C@H](N)C(=O)O>>COC(=O)[C@@H](N)CC#CCNC(=O)OC(C)(C)C,,CCO,CCOCC,,,val
US20090318442A1,C=[N+](C)C.O=c1[nH]c2scnc2c2c(O)cccc12.[Cl-]>>CN(C)Cc1nc2c([nH]c(=O)c3cccc(O)c32)s1.Cl,,CC#N,CN(C)C=O,,,val
US20100125062A1,O=C1C=C(c2cccnc2F)CCC1>>O[C@H]1CCC[C@H](c2cccnc2F)C1,,C1CCOC1,,,,val
US20090176823A1,CC(C)(C)[SiH2]OC(C)(C)c1cc(C=O)ccc1Cl.CC1(C)OC(=O)CC(=O)O1>>O=C(O)CCc1ccc(Cl)c(CO)c1,,CN(C)C=O,O,CCN(CC)CC,O=CO,val
US20090018103A1,COCCCC[C@@](O)(c1cccc2ccoc12)[C@@H]1CCCN(C(=O)N[C@@H](CC2CCCC2)CN(C)C(=O)OCc2ccccc2)C1>>CNC[C@H](CC1CCCC1)NC(=O)N1CCC[C@@H]([C@@](O)(CCCCOC)c2cccc3c2OCC3)C1,Cl[Pd]Cl,CCOC(C)=O,,,,val
US20040006141A1,CCCCC(Cc1ccc(OCCO)cc1)C(=O)OCC.CS(=O)(=O)Cl>>CCCCC(Cc1ccc(OCCOS(C)(=O)=O)cc1)C(=O)OCC,,CCN(CC)CC,,,,val
US04873236,CCN(CC)CCCC1CCN(CCN)CC1.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>CCN(CC)CCCC1CCN(CCNC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1,,CCOC(C)=O,,,,val
US20150299165A1,CC(C)(C)OC(=O)N1CCC2(CC(O)CO2)C1.Cl>>Cl.OC1COC2(CCNC2)C1,,C1COCCO1,,,,val
US20090275606A1,Nc1ccc(I)cc1F.O=C(O)c1c(Cl)cc(=O)n2c1CCC2>>O=C(O)c1c(Nc2ccc(I)cc2F)cc(=O)n2c1CCC2,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20130289033A1,Cc1cccc(C)c1B(O)O.O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(I)cc1>>Cc1cccc(C)c1-c1ccc(C(=O)NCCc2c[nH]c3ccc(Cl)cc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20130172354A1,CC(C)(C)OC(=O)N(CC1CCOC(C)(C)C1)c1ccc(Cl)c(-c2cc(F)ncc2Cl)n1.N[C@H]1CC[C@H](N)CC1>>CC1(C)CC(CNc2cc([C@@H]3CC[C@@H](N)CC3)c(Cl)c(-c3cc(N)ncc3Cl)n2)CCO1,,CS(C)=O,O,CCN(C(C)C)C(C)C,,val
US20160243100A1,Cn1ccc(C(F)F)n1.II>>Cn1nc(C(F)F)cc1I,,C1CCOC1,,[Li]CCCC,,val
US20160024050A1,CC(C)(C)OC(=O)NC1CCNCC1.CN1CCC(=O)CC1>>CN1CCC(N2CCC(NC(=O)OC(C)(C)C)CC2)CC1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US07199105B2,CCCCCC1CNC(C(=O)NC(C(C)C)C2OC(SC)C(O)C(O)C2O)C1.OCCCBr>>CCCCCC1CC(C(=O)NC(C(C)C)C2OC(SC)C(O)C(O)C2O)N(CCCO)C1,,CC#N,,CCN(CC)CC,,val
US20050171109A1,CC(C)(CC(O)(C=Nc1cccc2[nH]ncc12)C(F)(F)F)c1ccccc1>>CC1(C)CC(O)(C(F)(F)F)C(Nc2cccc3[nH]ncc23)c2ccccc21,Cl[Ti](Cl)(Cl)Cl,ClCCl,,O=C([O-])O.[Na+],,val
US04889867,FC(F)(F)c1ccc(-c2nccs2)cc1.ICCI>>FC(F)(F)c1ccc(-c2ncc(I)s2)cc1,,CCCCCC,CCOCC,[Li]CCCC,,val
US20130336920A1,CCN(CC)c1ccc(NC(=O)c2cccc(C#CCOCCOCCOCCOCCO)c2)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1>>CCN(CC)c1ccc(NC(=O)c2cccc(CCCOCCOCCOCCOCCO)c2)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1,[Pd],CO,,,,val
US20050165063A1,CCCN(CCC)CCN1CCNCC1.O=C(O)c1ccc(CN(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1>>CCCN(CCC)CCN1CCNCC1C(=O)c1ccc(CN(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20120172391A1,C=Cc1cnc(C=C)c(C(=O)OC)c1.COc1ccc(CN)cc1>>C=Cc1cnc2c(c1)C(=O)N(Cc1ccc(OC)cc1)CC2,,CC(=O)N(C)C,,,,val
US20070249607A1,Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCN(C(=O)OC(C)(C)C)CC2)cc(C(F)(F)F)c1>>Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1,,CCOC(C)=O,,Cl,,val
US20050143579A1,CC(C)(C)OC(=O)N1CCN(CC(c2cccc(C#C[Si](C)(C)C)c2)C2(O)CCCCC2)CC1>>C#Cc1cccc(C(CN2CCN(C(=O)OC(C)(C)C)CC2)C2(O)CCCCC2)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20110034416A1,O=[N+]([O-])c1ccc(F)c(F)c1.O=c1cc[nH]c(N=C(c2ccccc2)c2ccccc2)c1Cl>>O=[N+]([O-])c1ccc(Oc2ccnc(N=C(c3ccccc3)c3ccccc3)c2Cl)c(F)c1,,CCO,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20140349990A1,CCOC(=O)c1nn(C2CC2)c(C(F)(F)F)c1C(O)c1ccc(Cl)cc1.Cc1cc(N)cn(C)c1=O>>CCOC(=O)c1nn(C2CC2)c(C(F)(F)F)c1C(Nc1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1,,CO,ClCCl,,,val
US20160068515A1,C1COCCN1.C=O.O=c1[nH]ncn1-c1ccc(Br)cc1F>>O=c1n(-c2ccc(Br)cc2F)cnn1CN1CCOCC1,,CCO,,,,val
US20070219192A1,CC(C)Oc1ccc(C(=O)O)cc1Cl>>CC(C)Oc1ccc(CO)cc1Cl,,C1CCOC1,,B,,val
US04493730,O=[N+]([O-])c1ccc(Cl)nc1.Oc1ccc(C(F)(F)F)cc1Cl>>O=[N+]([O-])c1ccc(Oc2ccc(C(F)(F)F)cc2Cl)nc1,,CS(C)=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US05541229,CCCCc1nc2cc(C(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCCc1nc2cc(C(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04268673,C=CC1(O)c2cc(OC)ccc2CC(N(C)S(=O)(=O)c2ccc(C)cc2)C1(C)C>>COc1ccc2c(c1)C(=CCO)C(C)(C)C(N(C)S(=O)(=O)c1ccc(C)cc1)C2,,C1COCCO1,,O=S(=O)(O)O,,val
US20120028919A1,C[C@H](O)CN1CCN(c2ccc([N+](=O)[O-])cc2F)CC1>>C[C@H](O)CN1CCN(c2ccc(N)cc2F)CC1,[Pd],,,CO,,val
US05274116,Nn1cccc1.O=C(NC(CO)C(=O)O)OCc1ccccc1>>O=C(NC(CO)C(=O)Nn1cccc1)OCc1ccccc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20070259877A1,O=[N+]([O-])c1cc(I)ccc1Cl>>Nc1cc(I)ccc1Cl,[Fe],CO,O,[Cl-].[NH4+],,val
US20100179216A1,Cc1ccc(C=CCOc2ccc(CCC3(NC(=O)OC(C)(C)C)COC(C)(C)OC3)cc2C(F)(F)F)cc1.Cl>>Cc1ccc(C=CCOc2ccc(CCC(N)(CO)CO)cc2C(F)(F)F)cc1.Cl,,CCO,,,,val
US20050137162A1,BrBr.Oc1ccc(C(F)(F)F)cc1O>>Oc1cc(C(F)(F)F)cc(Br)c1O,,ClC(Cl)(Cl)Cl,,,,val
US20140024646A1,COC(=O)[C@H]1C=C[C@@H](NC(=O)OC(C)(C)C)C1>>COC(=O)C1=CC[C@@H](NC(=O)OC(C)(C)C)C1,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US20070249670A1,COC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1N)[C@@H](C)OC1(C)CCCC1.Cc1cc(C)c(N=C=O)c(C)c1>>COC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C)[C@@H](C)OC1(C)CCCC1,,c1ccncc1,,,,val
US20120220635A1,CCCN1CCCC1Cc1ccccc1.O=[N+]([O-])O>>CCCN1CCCC1Cc1ccc([N+](=O)[O-])cc1,,C[N+](=O)[O-],,O,O=S(=O)(O)O,val
US05153226,CC(C)c1cccc(C(C)C)c1N.Cc1ccc(S(=O)(=O)Cl)cc1.N[C@@H](Cc1ccccc1)C(=O)O>>Cc1ccc(S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)Nc2c(C(C)C)cccc2C(C)C)cc1,,ClCCl,,CCN(CC)CC,,val
US20080027076A1,CC#Cc1cccc(NC(=O)Nc2cc(C(C)(C)C)nn2C)c1.Clc1ncncc1I>>Cn1nc(C(C)(C)C)cc1NC(=O)Nc1cccc(C#Cc2cncnc2Cl)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,CCN(CC)CC,,val
US20100029710A1,CCc1nc2c(C)cc(CC3CCCC3=O)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnnn3C(c3ccccc3)(c3ccccc3)c3ccccc3)ccc21>>CCc1nc2c(C)cc(CC3CCCC3O)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20010023249A1,CC(C)CCN(c1ccc(O)cc1)C1CCN(C(=O)OC(C)(C)C)CC1.CS(=O)(=O)OCc1ccc(F)cc1>>CC(C)CCN(c1ccc(OCc2ccc(F)cc2)cc1)C1CCN(C(=O)OC(C)(C)C)CC1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20100087429A1,CC(C)(C)CI.CC(C)(C)NC1=NC2(CS1)c1cc(O)ccc1Oc1ccc(-c3cncnc3)cc12>>CC(C)(C)COc1ccc2c(c1)C1(CSC(NC(C)(C)C)=N1)c1cc(-c3cncnc3)ccc1O2,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110118221A1,CCOC(=O)C1=C(CBr)N(c2ccc(F)c(C(F)(F)F)c2)C(=O)NC1c1ccc(C#N)cc1.CNN>>CN1CC2=C(C(=O)N1)C(c1ccc(C#N)cc1)NC(=O)N2c1ccc(F)c(C(F)(F)F)c1,,C1COCCO1,,,,val
US04960884,COC(=O)c1ccc(OCCF)cc1>>OCc1ccc(OCCF)cc1,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20100099688A1,COC(=O)c1ccc(OC)c2c1OCC1(COCOC1)CO2.Cc1c(Cl)cncc1Cl>>COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2c1OCC1(COCOC1)CO2,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05668161,CSc1ccc(C(Br)C(=O)c2ccc(F)cc2)cc1.Cc1nc(C(N)=S)cs1>>CSc1ccc(-c2sc(-c3csc(C)n3)nc2-c2ccc(F)cc2)cc1,,CC#N,CCO,,,val
US20100152441A1,CC(C)(C)OC(=O)NC1CCN(CCn2c(=O)cnc3cc(C#N)ccc32)CC1>>N#Cc1ccc2c(c1)ncc(=O)n2CCN1CCC(N)CC1,,ClC(Cl)Cl,ClCCl,O=C(O)C(F)(F)F,,val
US20050222118A1,NCCCN1CC(Oc2ccc(F)cc2)C1.O=C(Cl)Oc1ccccc1>>NC(=O)Oc1ccccc1,,ClCCl,,CN(C)c1ccccn1,,val
US20120142659A1,CN[C@H](CN1CC(O)C1)C1CC1.Cc1cc(C(=O)O)ccc1F>>Cc1cc(C(=O)N(C)[C@H](CN2CC(O)C2)C2CC2)ccc1F,,CN(C)C=O,ClCCl,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20110130445A1,CC(C)(C)OC(=O)CCc1ccc(Cl)c(N)c1.CO>>COC(=O)CCc1ccc(Cl)c(N)c1,,CO,ClCCl,O,O=S(Cl)Cl,val
US20130065905A1,O=[N+]([O-])c1ccc2nc(OC(c3cccnc3)C(F)(F)F)c(Cl)nc2c1>>Nc1ccc2nc(OC(c3cccnc3)C(F)(F)F)c(Cl)nc2c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20040138498A1,NC1CCCCC1.O=C(O)C[C@@]1(C[N+](=O)[O-])C[C@H]2CCC[C@H]21>>NC1CCCCC1.O=C(O)C[C@@]1(C[N+](=O)[O-])C[C@H]2CCC[C@H]21,,CCOC(C)=O,,,,val
US20130324557A1,O=C(Cl)CBr.c1ccc(NCc2cccs2)cc1>>O=C(CBr)N(Cc1cccs1)c1ccccc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US04876261,Cl.O=CNc1c(O)ccc2c1CN(Cc1ccccc1)CC2c1ccc(O)c(O)c1>>Cl.O=CNc1c(O)ccc2c1CNCC2c1ccc(O)c(O)c1,,CCO,,,,val
US20090111800A1,O=C1[C@H](Cc2c(Cl)cc(OS(=O)(=O)C(F)(F)F)cc2Cl)CCN1[C@H]1CCc2nn(S(=O)(=O)C(F)(F)F)cc2C1.c1ccc(C2CCNCC2)cc1>>O=C1[C@H](Cc2c(Cl)cc(N3CCC(c4ccccc4)CC3)cc2Cl)CCN1[C@H]1CCc2n[nH]cc2C1,,CCOC(C)=O,,[Li+].[OH-],,val
US20040152690A1,Clc1cc(CBr)cnc1Cl.O=C1NC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1Cc1cnc(Cl)c(Cl)c1,,CN(C)C=O,,O,[K],val
US20050043401A1,Nc1cccc(S(F)(F)(F)(F)F)c1.O=N[O-]>>Oc1cccc(S(F)(F)(F)(F)F)c1,,O,,O=S(=O)(O)O,,val
US06313292B1,CC(C)(C)OC(=O)Nc1cnc(F)cc1C(=O)O>>Nc1cnc(F)cc1C(=O)O,,ClCCl,,O,O=C(O)C(F)(F)F,val
US20130259850A1,CCOC(=O)Cc1cccc(OCc2cc(C)cc(C)c2)c1>>Cc1cc(C)cc(COc2cccc(CC(=O)O)c2)c1,,CCO,,[Na+].[OH-],,val
US20140288105A1,C1=COCCC1.CCOC(=O)c1c[nH]nc1I>>CCOC(=O)c1cn(C2CCCCO2)nc1I,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20040048882A1,CC(C)OC(=O)c1ccc(C(O)(c2ccc3c(c2)c(-c2cccc(Cl)c2)cc(=O)n3C)c2cncn2C)cc1>>Cn1cncc1C(O)(c1ccc(C(=O)O)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2C,,C1CCOC1,O,[Li+].[OH-],,val
US20160158207A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)OCc1cccc2c1CCN2>>CC(C)(C)OC(=O)N1CCc2c(CO[Si](C)(C)C(C)(C)C)cccc21,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US05254576,COc1cccc(-c2ocnc2C(N)=O)c1>>NC(=O)c1ncoc1-c1cccc(O)c1,,ClCCl,,BrB(Br)Br,CO,val
US20070244159A1,O=[N+]([O-])c1ccc2[nH]c(C3CC3)cc2c1>>Nc1ccc2[nH]c(C3CC3)cc2c1,[Ni],CO,,,,val
US20090054407A1,CC(C)(N)c1ccccc1.O=C(Cl)c1ccc(F)c(Cl)c1>>CC(C)(NC(=O)c1ccc(F)c(Cl)c1)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20040248918A1,CS(=O)(=O)O.Cc1ccc(Nc2nccc(-c3cccnc3)n2)cc1NC(=O)c1ccc(CNN2CCN(C)CC2)cc1>>CS(=O)(=O)O.Cc1ccc(Nc2nccc(-c3cccnc3)n2)cc1NC(=O)c1ccc(CNN2CCN(C)CC2)cc1,,CCO,,,,val
US20120122840A1,Clc1nc(Cl)c2ncn(C3CCCCO3)c2n1.N[C@@H]1CC[C@@H](CO)CC1>>OCC1CCC(Nc2nc(Cl)nc3c2ncn3C2CCCCO2)CC1,,CC(C)O,,CCN(CC)CC,,val
US20030195176A1,CC(=O)SCC1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C.CCC(CC)(CCCBr)O[Si](CC)(CC)CC>>CCC(CC)(CCCSCC1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C)O[Si](CC)(CC)CC,,C1CCOC1,,CO,[K+].[OH-],val
US20060257987A1,COC(=O)CCc1ccc(OCC[C@H](C)Oc2ccc(Cl)cc2-c2ccccn2)cc1C>>Cc1cc(OCC[C@H](C)Oc2ccc(Cl)cc2-c2ccccn2)ccc1CCC(=O)O,,CO,,Cl,[Na+].[OH-],val
US20100286136A1,Cc1cccc(N)c1.O=C(Cl)C=Cc1ccccc1>>Cc1cccc(NC(=O)C=Cc2ccccc2)c1,,ClCCl,,c1ccncc1,,val
US04927926,CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CC(C)(NC(=O)C(F)(F)F)C3)c(F)c21>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CC(C)(N)C3)c(F)c21,,O,,CCO,[Na+].[OH-],val
US20150073011A1,C=CCON.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>C=CCONS(=O)(=O)c1ccccc1[N+](=O)[O-],,ClCCl,,Cl,c1ccncc1,val
US06492416B1,CCC(C)(O)C#CC(O)c1ccc(SC)cc1>>CCC(C)(O)C#CC(=O)c1ccc(SC)cc1,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20090082440A1,CC(C)(COS(=O)(=O)CCCCl)[C@@H](OCc1ccccc1)C(=O)O.CC(C)CO>>CC(C)COC(=O)[C@H](OCc1ccccc1)C(C)(C)COS(=O)(=O)CCCCl,,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20090012134A1,N#Cc1ccccc1S(=O)(=O)c1ccc([N+](=O)[O-])cc1>>N#Cc1ccccc1S(=O)(=O)c1ccc(N)cc1,[Fe],CCO,,Cl,,val
US20050261268A1,CC(=O)N1C(C)CN(c2cc(-n3cnc(Nc4ccc(N)cc4)n3)ccn2)CC1C.O=C(Cl)c1ccco1>>CC(=O)N1C(C)CN(c2cc(-n3cnc(Nc4ccc(NC(=O)c5ccco5)cc4)n3)ccn2)CC1C,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,ClCCl,val
US20110136763A1,CC1(C)OB(c2cc(OC3CCCCO3)cc(F)c2C=O)OC1(C)C.CCOC(=O)CBr>>CCOC(=O)CC1OB(O)c2cc(OC3CCCCO3)cc(F)c21,[Zn],C1CCOC1,,C[Si](C)(C)Cl,,val
US20060079685A1,CCOC(=O)c1cccnc1Cl>>OCc1cccnc1Cl,,CCO,,[BH4-].[Na+],,val
US04874775,CS(=O)(=O)Cl.c1ccc(NCc2cccnc2)cc1>>CS(=O)(=O)N(Cc1cccnc1)c1ccccc1,,ClCCl,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20150291599A1,Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1.N[C@H]1CCCC[C@@H]1O>>O[C@H]1CCCC[C@@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20150210688A1,COc1c[nH]nc1C#N.O=C1CCC(=O)N1I>>COc1c(C#N)n[nH]c1I,,CN(C)C=O,,,,val
US20030078439A1,CN(C)CC(=O)Cl.COc1cc(NS(=O)(=O)c2ccc3c(ccn3C)c2)cc(OC)c1OC>>COc1cc(N(C(=O)CN(C)C)S(=O)(=O)c2ccc3c(ccn3C)c2)cc(OC)c1OC,CN(C)c1ccncc1,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20090227628A1,COC(=O)CCCc1cccc2nc(NCc3ccc(C)o3)ccc12>>Cc1ccc(CNc2ccc3c(CCCCO)cccc3n2)o1,,C1CCOC1,,[BH4-].[Li+],,val
US04747869,CC(C)(C(=O)CCl)C1OCCO1.c1c[nH]cn1>>CC(C)(C(=O)Cn1ccnc1)C1OCCO1,,CC#N,,,,val
US20100004331A1,CCOC(=O)Cc1ccc(OC)c(Oc2ccc(N)cc2CSCC(F)(F)F)c1.O=C(Cl)c1ccc(Cl)cc1>>CCOC(=O)Cc1ccc(OC)c(Oc2ccc(NC(=O)c3ccc(Cl)cc3)cc2CSCC(F)(F)F)c1,,ClCCl,,CCN(CC)CC,,val
US20100217001A1,CCc1nn2c(-c3c(OC)cc(COC4CCCCO4)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1>>CCc1nn2c(-c3c(OC)cc(CO)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1,,Cc1ccccc1,,Cl,,val
US20140242028A1,COc1ccc(Sc2c(Cl)cc(N)cc2C(F)(F)F)cc1.S=C(n1ccnc1)n1ccnc1>>COc1ccc(Sc2c(Cl)cc(N=C=S)cc2C(F)(F)F)cc1,,ClCCl,,,,val
US20060128790A1,CCOC(=O)C1(CO)CCC1>>CCOC(=O)C1(C=O)CCC1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20090156582A1,COC(=O)c1n[nH]cc1N.O=C(O)c1ccccn1>>COC(=O)c1n[nH]cc1NC(=O)c1ccccn1,,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20040058907A1,O=C(OCc1ccccc1)N1CCOC(CNC(=O)C(F)(F)F)C1>>NCC1CN(C(=O)OCc2ccccc2)CCO1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20110183985A1,CC(=O)c1ccc2ccccc2c1O.O=C1CCC(=O)N1Cl>>CC(=O)c1cc(Cl)c2ccccc2c1O,,CC(=O)O,,,,val
US20040132727A1,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCCOc1ccc(Cl)cc1>>COc1cc2nccc(Oc3ccc(NC(=O)OCCCOc4ccc(Cl)cc4)cc3)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US04366153,CC(C)(C)OC(=O)NCCCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nnnn3CCNC(=O)OC(C)(C)C)CS[C@H]12)c1csc(NC=O)n1>>NCCCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nnnn3CCN)CS[C@H]12)c1csc(N)n1,,CO,,Cl,,val
US20080255128A1,CC1C(=O)N(c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C(=O)N1CCO.CS(=O)(=O)Cl>>CC1C(=O)N(c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C(=O)N1CCOS(C)(=O)=O,,ClCCl,O,CCN(CC)CC,,val
US20060276465A1,Cc1nc2cc(C3=CCC(C(C)(C)C)CC3)c([N+](=O)[O-])cc2s1>>Cc1nc2cc(C3=CCC(C(C)(C)C)CC3)c(N)cc2s1,[Pd],CO,,,,val
US20090247516A1,NCc1ccc2c(c1)OCO2.O=C(O)CSC(=S)SCC(=O)O>>O=C1CSC(=S)N1Cc1ccc2c(c1)OCO2,,[Na+],[OH-],,,val
US20090227541A1,CC(CO)CO.COC(C)(C)OC>>CC1(C)OCC(CO)CO1,,C1CCOC1,,,,val
US20050049310A1,COC(=O)[C@H](Cc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1)NC(=O)c1ccccc1OCc1ccc(-c2ccccc2)cc1>>O=C(N[C@@H](Cc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1)C(=O)O)c1ccccc1OCc1ccc(-c2ccccc2)cc1,,C1CCOC1,CO,[Li+].[OH-],,val
US20130040931A1,Cc1cccc(C(Cl)c2ccccc2)c1-c1ccc2nc(N)c(N3CCOCC3)cc2c1.c1c[nH]cn1>>Cc1cccc(C(c2ccccc2)n2ccnc2)c1-c1ccc2nc(N)c(N3CCOCC3)cc2c1,,CC#N,,Cl,,val
US20110207714A1,CCOC(=O)c1cc(C)oc1C(F)(F)F.O=C1CCC(=O)N1Br>>CCOC(=O)c1cc(CBr)oc1C(F)(F)F,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,ClCCl,O=C([O-])O.[Na+],val
US20050148624A1,CCC(O)CNCc1ccc(SC)cc1.O=C(O)c1ccc(Br)cc1C(=O)c1ccccc1>>CCC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(SC)cc1,,CCN(CC)CC,CN(C)C=O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20160002225A1,Cc1cnc(Br)s1.OB(O)c1cccc(O)c1>>Cc1cnc(-c2cccc(O)c2)s1,,C1COCCO1,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20110275673A1,COC(=O)c1ccc(CO[Si](C)(C)C(C)(C)C)cc1.NN>>CC(C)(C)[Si](C)(C)OCc1ccc(C(=O)NN)cc1,,CCO,O,[C-]#N.[Na+],,val
US20090203753A1,O=C(CCOCCc1ccccc1)NCCO>>OCCNCCCOCCc1ccccc1,,C1CCOC1,CO,,,val
US20080161278A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(O)[C@@H]1CCN1>>CC(C)(C)OC(=O)N1CCC1C(=O)O,,O,,C1COCCO1,,val
US20040229844A1,CCOC(=O)CC1CCCn2c1c(Sc1ccc(Cl)cc1)c1c(S(C)(=O)=O)ccnc12>>CS(=O)(=O)c1ccnc2c1c(Sc1ccc(Cl)cc1)c1n2CCCC1CC(=O)O,,C1CCOC1,CO,[Na+].[OH-],,val
US20120028931A1,C(=C1CCNCC1)c1cc2ccccc2s1.Cc1ccc([N+](=O)[O-])c(Cl)n1>>Cc1ccc([N+](=O)[O-])c(N2CCC(=Cc3cc4ccccc4s3)CC2)n1,,CC(=O)N(C)C,,CCN(CC)CC,O,val
US20040132727A1,CCN(CC)CC(C)N.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.S=C(Cl)Cl>>CCN(CC)CCCNC(=S)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(C)c1C,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20140256926A1,C=O.CCCC[P+](CCCC)(CCCC)CCCNC(=O)c1ccc(CC)c([N+](=O)[O-])c1.[Br-]>>CCCC[P+](CCCC)(CCCC)CCCNC(=O)c1ccc(C(C)CO)c([N+](=O)[O-])c1.[Br-],,CO,CS(C)=O,Cl,CC(C)(C)[O-].[K+],val
US20050014840A1,O.O=S(Cl)Cl.c1ccc(COc2ccccc2)cc1>>O=S(=O)(Cl)c1ccc(OCc2ccccc2)cc1,,ClCCCl,,CCOC(C)=O,,val
US20110212998A1,CCC(CC)c1cc(C(=O)OC)cc(OC)n1>>CCC(CC)c1cc(C(=O)O)cc(OC)n1,,Cl,,,,val
US20120289474A1,COCc1noc(CCl)n1.COc1cc(F)ccc1-c1cc2[nH]c(=O)n(C3CCN(C(=O)OC(C)(C)C)CC3)c(=O)c2s1>>COCc1noc(Cn2c(=O)n(C3CCN(C(=O)OC(C)(C)C)CC3)c(=O)c3sc(-c4ccc(F)cc4OC)cc32)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160166560A1,COc1ccc(F)c(CN2CCC(N(C)C(=O)n3cnc(-c4cccc(C(N)=O)c4)c3)CC2)c1.Cl>>COc1ccc(F)c(CN2CCC(N(C)C(=O)n3cnc(-c4cccc(C(N)=O)c4)c3)CC2)c1.Cl,,CO,,CCOCC,,val
US20080167287A1,CC(C)(C)OC(=O)[C@@H](NC(=O)c1ccc(-c2cnc3ncc(C4(c5ccc6ncccc6c5)CC4)n3c2)cc1F)C(C)(C)C.Cl>>CC(C)(C)[C@H](NC(=O)c1ccc(-c2cnc3ncc(C4(c5ccc6ncccc6c5)CC4)n3c2)cc1F)C(=O)O.Cl,,C1COCCO1,,,,val
US20070232594A1,NCCN1Cc2ccccc2N(C(=O)c2ccc(N3CCCC3)cc2Cl)CC1=O.O=C(Cl)c1ccccc1>>O=C(NCCN1Cc2ccccc2N(C(=O)c2ccc(N3CCCC3)cc2Cl)CC1=O)c1ccccc1,,ClCCl,,CCN(CC)CC,O,val
US04886814,O=C1COC(c2csc(C(F)(F)F)n2)CN1>>FC(F)(F)c1nc(C2CNCCO2)cs1,,C1CCOC1,,CC(=O)O,[BH4-].[Na+],val
US20130172339A1,CC(=O)CSc1ccc(C)cc1>>Cc1ccc2scc(C)c2c1,,Clc1ccccc1,,,,val
US20110312930A1,O=S(Cl)Cl.OCc1ccc(CN2CCCC2)cc1>>Cl.ClCc1ccc(CN2CCCC2)cc1,,ClCCl,,,,val
US20060030613A1,N#CC1(c2ccc(CN(CCc3cccc(C(F)(F)F)c3)C(=O)C(F)(F)F)cc2)CC1>>N#CC1(c2ccc(CNCCc3cccc(C(F)(F)F)c3)cc2)CC1,,CCO,,O,[BH4-].[Na+],val
US20070003539A1,CC(=O)Nc1cc2cc([N+](=O)[O-])ccc2c(Br)n1>>CC(=O)Nc1cc2cc(N)ccc2cn1,[Pd],CCO,,CO,Cl,val
US20140171432A1,CCCBr.O=[N+]([O-])c1c[nH]c2ccc(F)cc12>>CCCn1cc([N+](=O)[O-])c2cc(F)ccc21,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120041009A1,CC(C)c1nc(C#N)cc(C(F)(F)F)n1.NO>>CC(C)c1nc(C(N)=NO)cc(C(F)(F)F)n1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20130190289A1,COC(=O)[C@H](COCCN(C)C(=O)OC(C)(C)C)NC(=O)OCc1ccccc1>>CNCCOC[C@H](NC(=O)OCc1ccccc1)C(=O)OC,,ClCCl,O=C(O)C(F)(F)F,,,val
US20150252030A1,Cc1cc([N+](=O)[O-])cc(C)c1OCC(=O)N/N=C/c1cccc2[nH]ccc12>>Cc1cc(N)cc(C)c1OCC(=O)N/N=C/c1cccc2[nH]ccc12,[Zn],CC(=O)O,,,,val
US20110111046A1,COC(=O)c1cc(Br)c2[nH]c(=O)[nH]c2c1>>O=C(O)c1cc(Br)c2[nH]c(=O)[nH]c2c1,,CO,,[Na+].[OH-],,val
US20120065214A1,COC(=O)c1ccc(C)c(-n2ccnc(NC3(c4ccccc4O)CC3)c2=O)c1.ClCCBr>>COC(=O)c1ccc(C)c(-n2ccnc(NC3(c4ccccc4OCCCl)CC3)c2=O)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04510086,CC(=O)SC1=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)N2C(=O)CC2S1>>O=C(OCc1ccc([N+](=O)[O-])cc1)C1C(=S)SC2CC(=O)N21,,C1COCCO1,O,c1c[nH]cn1,,val
US20020151547A1,CS(=O)(=O)Cl.Cc1ccc(C2CN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CCC2N2CCN(C(=O)C(F)(F)F)CC2)cc1>>Cc1ccc(C2CN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CCC2N2CCN(S(C)(=O)=O)CC2)cc1,,ClC(Cl)Cl,,,,val
US20110301155A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1n[nH]c2ccc(-c3ncccc3Cl)cc12>>CC(C)(C)OC(=O)n1nc(N)c2cc(-c3ncccc3Cl)ccc21,CN(C)c1ccncc1,CCOC(C)=O,,C1CCOC1,CCN(CC)CC,val
US20070244159A1,CC(C)(C)c1cc2cc([N+](=O)[O-])cc(CO)c2[nH]1>>CC(C)(C)c1cc2cc(N)cc(CO)c2[nH]1,[Ni],CO,,,,val
US20140163026A1,CC(C)(C)OC(=O)N1CC=C(c2ccc(N)cc2)CC1.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)N1CC=C(c2ccc(NC(=O)OCc3ccccc3)cc2)CC1,,Cc1ccccc1,O,[Na+].[OH-],,val
US04695567,CC1(C)C(=O)Nc2cc(NC(=O)c3ccco3)c(N)cc21>>CC1(C)C(=O)Nc2cc3[nH]c(-c4ccco4)nc3cc21,,CCO,,Cl,,val
US20110136792A1,COC(=O)c1cncc(COc2ccc(-c3cc(F)c(F)cc3OC)cc2)c1>>COc1cc(F)c(F)cc1-c1ccc(OCc2cncc(CO)c2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05658902,CCN1CCCC(N)C1.Clc1nc(C(Cl)(Cl)Cl)nc2ccc(I)cc12>>CCN1CCCC(Nc2nc(C(Cl)(Cl)Cl)nc3ccc(I)cc23)C1.Cl,,CCOCC,,,,val
US06846833B2,COC(=O)CC(=O)CC(=O)OC.Nc1ccccc1CO>>COC(=O)CC(CC(=O)OC)Nc1ccccc1CO,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05043466,COc1ccc(C(C(=S)N(C)C)C2(O)CCCCC2)cc1>>COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1,[Ni],C1COCCO1,CC(=O)O,,,val
US20030207877A1,CC(=O)c1ccccn1.CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C>>C=C(O[Si](C(C)C)(C(C)C)C(C)C)c1ccccn1,,CCOCC,,CCN(C(C)C)C(C)C,ClCCl,val
US20150353499A1,C#Cc1ccc2ccccc2c1CO.CS(=O)(=O)Cl>>C#Cc1ccc2ccccc2c1COS(C)(=O)=O,,ClCCl,,,,val
US20060041003A1,CCCCC12CCCC(=O)C(C)=C1c1ccc(OCOC)cc1C2>>CCCCC12CCCC(=O)C(C)=C1c1ccc(O)cc1C2,,CO,ClCCl,Cl,O=C([O-])O.[Na+],val
US20140088101A1,COC(=O)c1ncc2c(=O)n(Cc3ccc(OC)cc3OC)ccc2c1O.COCCN>>COCCNC(=O)c1ncc2c(=O)n(Cc3ccc(OC)cc3OC)ccc2c1O,,CCO,,CC(=O)O,O,val
US20100256163A1,OCCI.Oc1c(OC(F)(F)F)cccc1C1CCNCC1>>OCCN1CCC(c2cccc(OC(F)(F)F)c2O)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040054182A1,CC(C)(C)OC(=O)N1CCC(CCN)CC1.O=[N+]([O-])c1c(C(F)(F)F)nc2ccccc2c1Cl>>CC(C)(C)OC(=O)N1CCC(CCNc2c([N+](=O)[O-])c(C(F)(F)F)nc3ccccc23)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070244132A1,CC(C)(C)OC(=O)NCCn1ccc2ncnc(Cl)c21.Nc1ccc(Oc2cccc(OC(F)(F)F)c2)c(Cl)c1>>CC(C)(C)OC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(OC(F)(F)F)c4)c(Cl)c3)c21,,CC(C)O,,O=C([O-])O.[Na+],,val
US20050222201A1,CC(=O)O.Cc1c(-c2ccnc3cc(Cl)ccc23)c2cc(Cl)ccc2n1CC(=O)O>>CC(=O)OCc1c(-c2ccnc3cc(Cl)ccc23)c2cc(Cl)ccc2n1CC(=O)O,,ClCCCl,,O=C1CCC(=O)N1Br,,val
US20080214620A1,BrCc1ccccc1.Sc1nnc(-c2ccc3nc[nH]c3c2)o1>>c1ccc(CSc2nnc(-c3ccc4[nH]cnc4c3)o2)cc1,,CCO,,,,val
US20060035956A1,CCOC(=O)Cn1ccc2cccc(O)c21.CS(=O)(=O)OCCCC#Cc1ccc(OC(F)(F)F)cc1>>CCOC(=O)Cn1ccc2cccc(OCCCC#Cc3ccc(OC(F)(F)F)cc3)c21,,CC#N,,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20100227859A1,COC(=O)CNS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3nccs3)cc12>>O=C(O)CNS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3nccs3)cc12,,C1CCOC1,O,[Li+].[OH-],,val
US20150376181A1,COC(=O)CC1(CC(=O)OC)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n21>>O=C1NC(CCO)(CCO)n2c1c(Cl)cc(Nc1ccncn1)c2=O,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090137595A1,CC(=O)Nc1cn2nc(I)ccc2n1.Nc1cc(O)ccc1F>>CC(=O)Nc1cn2nc(Oc3ccc(F)c(N)c3)ccc2n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040147748A1,C=CCc1cnc(N)cn1.CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)O)cc1Cl>>C=CCc1cnc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)cn1,CN(C)C=O,CCOC(C)=O,ClCCl,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20020045628A1,Cc1[nH]c2ccccc2c1C1=CCC2(CC1)OCCO2>>Cc1[nH]c2ccccc2c1C1CCC2(CC1)OCCO2,[Pd],CCO,,,,val
US20020099212A1,COC(=O)c1ccc2nccc(Br)c2c1>>O=C(O)c1ccc2nccc(Br)c2c1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US03962255,CC(C)CC(=O)NCC(C)(C)N.CCOC(=O)Cl>>CCOC(=O)N(CC(C)(C)N)C(=O)CC(C)C,,Cc1ccccc1,,,,val
US20120238549A1,Cc1ncccc1NC(=O)c1ccc2c(c1)CCC[C@@H]1CC(=O)CC[C@]21Cc1ccccc1.Cc1ncccc1NC(=O)c1ccc2c(c1)CCC[C@H]1CC(=O)CC[C@@]21Cc1ccccc1>>Cc1ncccc1NC(=O)c1ccc2c(c1)CCC[C@@H]1C[C@H](O)CC[C@]21Cc1ccccc1.Cc1ncccc1NC(=O)c1ccc2c(c1)CCC[C@H]1C[C@@H](O)CC[C@@]21Cc1ccccc1,,CCO,,[BH4-].[Na+],,val
US04772600,CN.O=C(O)Cn1c(-c2ccc([N+](=O)[O-])cc2)nc2cccnc21>>CNC(=O)Cn1c(-c2ccc([N+](=O)[O-])cc2)nc2cccnc21,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US06265411B1,COc1cc2c(Cl)ncnc2cc1OCCCN1CCOCC1.O=C1Cc2cccc(OCc3ccccc3)c2N1>>COc1cc2c(C3C(=O)Nc4c(OCc5ccccc5)cccc43)ncnc2cc1OCCCN1CCOCC1,,C1CCOC1,,CN(C)C=O,[H-].[Na+],val
US20050113397A1,COC(=O)CO.O=C(Cl)c1ccccc1>>COC(=O)COC(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20150152068A1,CC#CC(=O)N(C)[C@@H](C)COc1c(-c2cc(F)cc(N(C(=O)OC(C)(C)C)C(=O)c3ccc(C4CC4)cc3)c2C)ncnc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CC#CC(=O)N(C)[C@@H](C)COc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C,O,ClCCl,,,,val
US06099593,Cl.O=[N+]([O-])c1cnn2c(O)ccnc12>>Cl.Nc1cnn2c(O)ccnc12,[Pd],CC(=O)O,,C1=CCCCC1,,val
US04145347,CC(O)C#N.CN1CCNCC1>>CC(C#N)N1CCN(C)CC1,,O,,c1ccccc1,,val
US20150315141A1,CC(C)(C)OC(=O)NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)c1ccc(C(F)(F)F)[nH]1>>NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)c1ccc(C(F)(F)F)[nH]1,,ClCCl,O,O=C(O)C(F)(F)F,,val
US20060111402A1,FC(F)(F)Cc1nc2cc(Cl)c(Cl)cc2[nH]1.O=C(CBr)c1ccc(F)cc1>>O=C(Cn1c(CC(F)(F)F)nc2cc(Cl)c(Cl)cc21)c1ccc(F)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20110288065A1,C[C@H](Nc1nc(Cl)cc(-c2cncnc2)n1)c1ccc(F)cc1.Nc1cnccn1>>C[C@H](Nc1nc(Nc2cnccn2)cc(-c2cncnc2)n1)c1ccc(F)cc1,,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20120157436A1,Cc1ccc(C(=O)O)c(C(F)(F)F)c1.O=C(Cl)C(=O)Cl>>Cc1ccc(C(=O)Cl)c(C(F)(F)F)c1,CN(C)C=O,ClCCl,,,,val
US20040121964A1,CC1(NC(=O)OCc2ccccc2)CCN(c2cncc(C#N)c2)CC1>>CC1(N)CCN(c2cncc(C#N)c2)CC1,[Pd],CC(C)O,,O=C[O-].[NH4+],,val
US20100160309A1,CCCCO.Cc1cc(N)cc(Cl)n1>>CCCCOc1cc(N)cc(C)n1,,CCCCO,O,[Na+].[OH-],,val
US07550484B2,Cc1cccnc1C1CCCC(c2ncccc2C)N1Cc1cccc(C#N)c1.NO>>Cc1cccnc1C1CCCC(c2ncccc2C)N1Cc1cccc(C(=N)NO)c1,,CO,O,CCN(CC)CC,,val
US20140335080A1,CC(C)(c1ccc(O)cc1)c1ccc(O)cc1.CC1(C)OC[C@H](CCl)O1>>CC1(C)OC[C@H](COc2ccc(C(C)(C)c3ccc(O)cc3)cc2)O1,,CN(C)C=O,,[H-].[Na+],,val
US20090247514A1,C1CCOC1.CC(=O)O.ClC(Cl)Cl.Nc1ccc2c(c1)CC1(C2)C(=O)Nc2ncccc21>>O=Cc1cnc2cc3c(cc2c1)CC1(C3)C(=O)Nc2ncccc21,,CC(=O)O,ClC(Cl)Cl,Cl,O=C([O-])O.[Na+],val
US04855291,CCOC(=O)c1cnc2cc(CC)ccc2c1O.CI>>CCOC(=O)c1cn(C)c2cc(CC)ccc2c1=O,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090118501A1,CC(=O)Nc1ncc(S(=O)(=O)Cl)s1.CN>>CNS(=O)(=O)c1cnc(N)s1,,C1CCOC1,,,,val
US06608059B1,CCOC(=O)c1cc2cc(OCc3c(Cl)cccc3Cl)ccc2[nH]1.N#CCCCBr>>CCOC(=O)c1cc2cc(OCc3c(Cl)cccc3Cl)ccc2n1CCCC#N,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20150337004A1,CC(C)(C)OC(=O)N1CCC[C@@H]1c1ncc(-c2ccccc2)[nH]1>>c1ccc(-c2cnc([C@@H]3CCCN3)[nH]2)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100317647A1,N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(F)cc3C(F)(F)F)C[C@H]2C(=O)N2CC(F)(F)C2)CC1.OC1COC1>>N#CC1(NC(=O)C2CC(S(=O)(=O)c3ccc(OC4COC4)cc3C(F)(F)F)CC2C(=O)N2CC(F)(F)C2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140221361A1,C=C(CNCCO)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC(C)(C)C)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(CNCCO)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050234265A1,CC(=O)NC(C)OC(C)C.CC(C)(C)c1cc(O)cc(C(C)(C)C)c1>>CC(=O)NC(C)c1c(O)cc(C(C)(C)C)cc1C(C)(C)C,,O=C(O)C(F)(F)F,,,,val
US20150376179A1,CC(=O)Cl.CCOC(=O)N1CCCC(N2CCC(n3nccc3CN)CC2)CC1>>CCOC(=O)N1CCCC(N2CCC(n3nccc3CNC(C)=O)CC2)CC1,,ClCCl,,,,val
US20130190288A1,CC(C)CBr.O=S(=O)(Cc1ccccc1)NCc1ccc(Br)cc1>>CC(C)CN(Cc1ccc(Br)cc1)S(=O)(=O)Cc1ccccc1,,CC(=O)N(C)C,CCOC(C)=O,O,[H-].[Na+],val
US20140128392A1,COC(=O)c1ccc2nc(-c3ccccc3)c(=O)[nH]c2c1.ClP(Cl)(Cl)(Cl)Cl>>COC(=O)c1ccc2nc(-c3ccccc3)c(Cl)nc2c1,,CC#N,,,,val
US04863921,COC(=O)c1cc(Cl)c(NC(C)=O)c2c1OC1CCCCC21>>COC(=O)c1cc(Cl)c(NC(C)=O)c2c3c(oc12)CCCC3,,c1ccccc1,,,,val
US20160176871A1,CC(=O)Nc1cc(C#Cc2nccc(C)c2NC(=O)C(F)(F)F)ccn1.FC(F)(F)c1csc(Br)n1>>CC(=O)Nc1cc(-c2[nH]c3c(C)ccnc3c2-c2nc(C(F)(F)F)cs2)ccn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070142407A1,Cc1nc2c(c(C)c(C)n2-c2c(C)cc(C)c3nsnc23)c(=O)[nH]1.O=P(Cl)(Cl)Cl>>Cc1nc(Cl)c2c(C)c(C)n(-c3c(C)cc(C)c4nsnc34)c2n1,,CCOC(C)=O,,,,val
US20120258950A1,CCOC(=O)CC(=O)OCC.Fc1cnc(F)c(F)c1>>CCOC(=O)C(C(=O)OCC)c1ncc(F)cc1F,,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05312924,CC(C)C[C@H](N)c1ccccc1N1CCCCC1.CCOC(=O)c1ccc(CC(=O)O)cc1OCC>>CCOC(=O)c1ccc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)cc1OCC,,Cc1ccccc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20020183337A1,CC(C)Cn1c(=O)n(C)c(=O)c2cc(Cc3ccc([N+](=O)[O-])cc3)sc21>>CC(C)Cn1c(=O)n(C)c(=O)c2cc(Cc3ccc(N)cc3)sc21,[Fe],CCO,O,[Cl-].[NH4+],,val
US20080008708A1,CCOC(=O)c1c(S(=O)(=O)NCCN)c2cc(Br)ccc2n1S(=O)(=O)c1ccccc1.O=S(=O)(Cl)c1ccc(Br)cc1>>CCOC(=O)c1c(S(=O)(=O)NCCNS(=O)(=O)c2ccc(Br)cc2)c2cc(Br)ccc2n1S(=O)(=O)c1ccccc1,,CCN(CC)CC,,Cl,,val
US20110059957A1,CC(C)(C)OC(=O)N1CCNCC1.Clc1cc(Cl)ncn1>>CC(C)(C)OC(=O)N1CCN(c2nccc(Cl)n2)CC1,,CC(C)O,,CCN(CC)CC,,val
US20100311747A1,CN(C)C(=O)N1CC2CC(C#N)CC2C1.ClCc1ccccc1>>CN(C)C(=O)N1CC2CC(C#N)(Cc3ccccc3)CC2C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20110003862A1,C/C=C/C#N.NNc1ccccn1>>CC1CC(N)=NN1c1ccccn1,,CCO,,[Na],,val
US20110105436A1,C1COCCN1.Cc1cccc(Nc2nc(-c3ccncc3)c(CO)s2)c1>>Cc1cccc(Nc2nc(-c3ccncc3)c(CN3CCOCC3)s2)c1,,ClCCl,,CCN(C(C)C)C(C)C,CS(=O)(=O)Cl,val
US20140213586A1,CN(C)CCO.CS(=O)(=O)Cl>>CN(C)CCOS(C)(=O)=O.Cl,,CCOCC,,,,val
US20070078164A1,COCCCOc1cc(C)ccc1CO.C[Si](C)(C)Br>>COCCCOc1ccccc1CBr,,ClC(Cl)Cl,,,,val
US05225601,CC1(C)CCC(C)(C)c2cc(OCc3ccc(C#N)cc3)ccc21.O.[OH-]>>CC1(C)CCC(C)(C)c2cc(OCc3ccc(C(=O)O)cc3)ccc21,,CCO,,Cl,,val
US20110034507A1,O=C1CCC(=O)N1Cl.ON=Cc1ccccc1OC(F)(F)F>>ON=C(Cl)c1ccccc1OC(F)(F)F,,CN(C)C=O,,O,,val
US20080114022A1,Cc1cc2cccnc2[nH]1.O=C(OO)c1cccc(Cl)c1>>Cc1cc2ccc[n+]([O-])c2[nH]1,,COCCOC,,O,O=C([O-])[O-].[K+].[K+],val
US20130109669A1,O=C(OC1CCCCC1)c1cc(OC2CCCCC2)nc(Cl)n1>>O=C(OC1CCCCC1)c1cc(OC2CCCCC2)ncn1,[Pd],O,,O=C[O-].[NH4+],,val
US04130654,C1CCNCC1.O=CCCC(=O)O>>C1CC[NH2+]CC1.O=CCCC(=O)[O-],,c1ccccc1,,,,val
US05194442,O=[N+]([O-])c1ccc2c(c1)C(O)CCCO2>>O=[N+]([O-])c1ccc2c(c1)C=CCCO2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20130137661A1,Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)C(=O)C2)c(=O)n(C[C@H](NC(=O)OC(C)(C)C)c2ccccc2)c(=O)n1Cc1c(F)cccc1F.O=C(O)C(F)(F)F>>Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)C(=O)C2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F,,ClCCl,,O=C([O-])O.[Na+],,val
US20100022484A1,C=C1CC(=O)O1.CC(O)C(F)(F)F>>CC(=O)CC(=O)OC(C)C(F)(F)F,,C1CCOC1,,CCN(CC)CC,,val
US20070004704A1,CCCI.COC(=O)c1c(C)cc(O)cc1O>>CCCOc1cc(C)c(C(=O)OC)c(O)c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20140309244A1,C/C(=N\O)c1cccc(C)n1.CO/N=C(\C)c1cccc(C#CCOS(C)(=O)=O)n1>>CO/N=C(\C)c1cccc(C#CCO/N=C(\C)c2cccc(C)n2)n1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20100323994A1,COc1ccc(CN)cc1.O=C(Nc1ccncc1F)c1cnc2c(Br)cc(Cl)nn12>>COc1ccc(CNc2cc(Cl)nn3c(C(=O)Nc4ccncc4F)cnc23)cc1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,O,val
US05616601,Cc1ccc(C2=NC(O)(C(F)(F)F)CN2c2ccc(S(C)(=O)=O)cc2)nc1>>Cc1ccc(-c2nc(C(F)(F)F)cn2-c2ccc(S(C)(=O)=O)cc2)nc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120149910A1,CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1ccc(F)c([N+](=O)[O-])c1.c1nc[nH]n1>>CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1ccc(-n2cncn2)c([N+](=O)[O-])c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120123113A1,Br.BrCCCCCCCc1cccnc1.OCCCCCCO>>BrCCCCCCCc1cccnc1.OCCCCCCBr,,CO,Cc1ccccc1,,,val
US20080027036A1,CO.O=C(O)C1(O)CN(C(c2ccccc2)c2ccccc2)C1>>COC(=O)C1(O)CN(C(c2ccccc2)c2ccccc2)C1,,CCOC(C)=O,,O=S(=O)(O)O,,val
US20050033005A1,CCCCS(=O)(=O)Cl.Nc1ccccc1>>CCCCS(=O)(=O)Nc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20160222028A1,CC1(C(=O)Cl)CCC1.COC(=O)c1ccc2c(c1)OCC(C)(C)NC2>>COC(=O)c1ccc2c(c1)OCC(C)(C)N(C(=O)C1(C)CCC1)C2,,C1CCOC1,,c1ccncc1,,val
US20070244105A1,CNC.Cl.O=S(=O)(c1cccc2ccccc12)c1nn2c3c(cccc13)OC(CCl)C2>>CN(C)CC1Cn2nc(S(=O)(=O)c3cccc4ccccc34)c3cccc(c32)O1.Cl,,CS(C)=O,O,CCOCC,,val
US20030229051A1,COc1ccc(CN)cc1.Fc1cc2c(Nc3cccc(Br)c3)ncnc2cn1>>COc1ccc(CNc2cc3c(Nc4cccc(Br)c4)ncnc3cn2)cc1,,CCO,,,,val
US20080021043A1,CC(C)CC[C@H](c1ccc(C(=O)c2ccccc2)cc1)N1CC[C@@H](C(C)C(=O)[O-])C[C@H]1c1ccc(C(F)(F)F)cc1>>CC(C)CC[C@H](c1ccc(C(=O)c2ccccc2)cc1)N1CC[C@@H](CC(=O)O)C[C@H]1c1ccc(C(F)(F)F)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20050043388A1,CC(C)(C)c1ccc(C(=O)NN)cc1.O=C1Nc2ccc(I)cc2C1=O>>CC(C)(C)c1ccc(C(=O)NN=C2C(=O)Nc3ccc(I)cc32)cc1,,CC(=O)O,,,,val
US20160168139A1,COc1ccc(COc2cc(N3CCOCC3)cc(-c3cccc4c3Sc3ccccc3S4)n2)cc1>>O=c1cc(N2CCOCC2)cc(-c2cccc3c2Sc2ccccc2S3)[nH]1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US07179823B1,CCOC(=O)CCc1cn(Cc2ccc(O)cc2)cc1-c1ccccc1.ClCc1cccc(-c2cnccn2)c1>>CCOC(=O)CCc1cn(Cc2ccc(OCc3cccc(-c4cnccn4)c3)cc2)cc1-c1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US20080292588A1,CCC(N)CC(=O)OC.O=Cc1ccc(F)cc1>>CCC(CC(=O)OC)NCc1ccc(F)cc1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20150344497A1,CC(C)O.C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CC#N)OC1>>C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CC#N)OC1.O,,CC(C)O,,,,val
US20100240717A1,C1CCOC1.CC(C)C#N.CC(C)CCBr>>CC(C)CCC(=O)C(C)C,,C1CCOC1,,CCOCC,Cl,val
US05616774,C1CCNCC1.CC(C)(C)c1cccc(C(C)(C)C)c1O.N#Cc1ccc(C=O)cc1>>CC(C)(C)c1cc(C(c2ccc(C#N)cc2)N2CCCCC2)cc(C(C)(C)C)c1O,,Cc1ccccc1C,,,,val
US04367226,CC(=O)OC[C@H]1O[C@@H](N2C(=O)C(=Cc3ccccc3)SC2=S)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.NCc1ccccc1>>OC[C@H]1O[C@@H](NC(=S)NCc2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O,,CO,,,,val
US05272252,CC(C)(C)c1cc(S)cc(C(C)(C)C)c1O.CCOC(=O)/N=N/C(=O)OCC>>CC(C)(C)c1cc(S)cc(C(C)(C)C)c1O.CCOC(=O)N=NC(=O)OCC,,C1COCCO1,,,,val
US07091199B1,NCc1cccc(F)c1.OCCCl>>OCCNCc1cccc(F)c1,,O,,[Na+].[OH-],,val
US20130158067A1,C=CC#N.O=Cc1cc(F)ccc1O>>N#CC1=Cc2cc(F)ccc2OC1,,[Na+],[OH-],C1CN2CCN1CC2,,val
US05516774,Cc1ccccc1C(=O)N(C)c1ccc(C(=O)Cl)cc1.c1ccc2c(c1)Cn1cccc1CN2>>Cc1ccccc1C(=O)N(C)c1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1,,ClCCl,O,C1CCOC1,CCN(CC)CC,val
US20150045560A1,CCCCC#Cc1cc2c(C)c(O)c(C#CCCCC)cc2c(C)c1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCCCC#Cc1cc2c(C)c(OS(=O)(=O)C(F)(F)F)c(C#CCCCC)cc2c(C)c1OS(=O)(=O)C(F)(F)F,,ClCCl,O,Cl,c1ccncc1,val
US20140213571A1,COc1ccc(Br)cc1C(=O)CBr.Nc1ccccn1>>COc1ccc(Br)cc1-c1cn2ccccc2n1,,CCO,,,,val
US04806549,CCCCCC(=O)C(=CNc1ccccc1OC)C(=O)OCC>>CCCCCC(=O)c1c[nH]c2c(OC)cccc2c1=O,,c1ccc(Oc2ccccc2)cc1,,,,val
US05424435,CC(CCO)CC(C)(C)C.[O-][n+]1c(Cl)cccc1Cl>>CC(CCOc1cccc(Cl)[n+]1[O-])CC(C)(C)C,,CS(C)=O,,[Na+].[OH-],,val
US20100093698A1,Brc1cccc(-c2cnc[nH]2)c1.C[Si](C)(C)CCOCCl>>C[Si](C)(C)CCOCn1cncc1-c1cccc(Br)c1,,CN(C)C=O,,[H-].[Na+],,val
US20150166465A1,CCC(C(=O)O)N(C)C.CCCCC/C=C\C/C=C\CCCCCCCCC(O)CCCCCCCC/C=C\C/C=C\CCCCC>>CCCCC/C=C\C/C=C\CCCCCCCCC(CCCCCCCC/C=C\C/C=C\CCCCC)OC(=O)CCCN(C)C,CN(C)c1ccncc1,ClCCl,ClCCl,CCN(C(C)C)C(C)C,CO,val
US05719145,O=C1CCCc2ccc([N+](=O)[O-])cc21.O=CC(=O)O>>O=C(O)C=C1CCc2ccc([N+](=O)[O-])cc2C1=O,,C1COCCO1,,O=S(=O)(O)O,,val
US20110053923A1,CCS(=O)(=O)C1(c2cc(N3CCOC[C@H]3C)nc(Cl)n2)CC1.OB(O)c1cccc2[nH]ccc12>>CCS(=O)(=O)C1(c2cc(N3CCOC[C@H]3C)nc(-c3cccc4[nH]ccc34)n2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20140323501A1,CC(N)=O.CCCC(=O)OCC(=O)c1ccc(Sc2ccc(C(=O)CC(NC(C)=O)(C(=O)OCC)C(=O)OCC)cc2)cc1>>CCCc1nc(-c2ccc(Sc3ccc(C(=O)CC(NC(C)=O)(C(=O)OCC)C(=O)OCC)cc3)cc2)co1,,Cc1ccccc1C,,CCOCC,FB(F)F,val
US06130228,COc1ccc(NN)cc1.O=C1C(=CO)Cc2ccccc21>>COc1ccc(-n2ncc3c2-c2ccccc2C3)cc1,,CCO,,Cl,Cl,val
US06329405B1,COc1c(OC)c(=O)c1=O.COc1ccc(C(NCC(c2ccccc2)c2ccccc2)c2cccc(N)c2)cc1>>COc1ccc(C(NCC(c2ccccc2)c2ccccc2)c2cccc(Nc3c(OC)c(=O)c3=O)c2)cc1,,CO,,,,val
US04783467,CCOC(=O)CN.Cc1cc(I)cc(C=O)c1N>>CCOC(=O)CNCc1cc(I)cc(C)c1N,,ClC(Cl)Cl,,,,val
US20080051387A1,O=CC1CCCCC1.c1nc(N2CCN(C3CCC3)CC2)nc2c1CCNCC2>>c1nc(N2CCN(C3CCC3)CC2)nc2c1CCN(CC1CCCCC1)CC2,,CC(=O)O,ClCCl,O=C([O-])[O-].[Na+].[Na+],,val
US20140221668A1,Cl.Fc1cc(F)c2c(c1)C[C@@H](n1c(CCNCc3ccccc3)c[nH]c1=S)CO2>>Cl.Fc1cc(F)c2c(c1)C[C@@H](n1c(CCNCc3ccccc3)c[nH]c1=S)CO2,,CO,,Cc1ccccc1,,val
US20100298290A1,C1CCNCC1.CCOC(=O)CC(C)Br>>CCOC(=O)CCCN1CCCCC1,,CCOC(C)=O,CN(C)C=O,,,val
US20150313864A1,CC1(C)OC(=O)/C(=C/C(=O)Cl)O1.CN>>CNC(=O)/C=C1\OC(C)(C)OC1=O,,ClCCl,,CCN(CC)CC,Cl,val
US20100029687A1,COC(=O)c1cc(F)c(N2CC[C@@H](CO)[C@H](c3ccccc3)C2)nc1Cl>>COC(=O)c1cnc(N2CC[C@@H](CO)[C@H](c3ccccc3)C2)c(F)c1,[Pd],CO,O,O=C[O-].[NH4+],,val
US05683623,CCCCCC(O)c1cccc(F)c1F>>CCCCCCc1cccc(F)c1F,[Pd],,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US08778939B2,Nc1cccnc1.O=C(O)c1cc(F)ccc1OCc1ccccc1>>O=C(Nc1cccnc1)c1cc(F)ccc1OCc1ccccc1,,CN(C)C=O,O,ClCCCl,On1nnc2ccccc21,val
US04120856,CCN(CC)S(F)(F)F.CN1C(=O)C(O)N=C(c2ccccc2F)c2cc(Cl)ccc21>>CN1C(=O)C(F)N=C(c2ccccc2F)c2cc(Cl)ccc21,,ClCCl,,,,val
US20140178336A1,CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1[C@@H](C)CC[C@H]1c1ncc(-c2ccc3c(c2)COc2cc4c(ccc5nc([C@@H]6CC[C@H](C)N6C(=O)OC(C)(C)C)[nH]c54)cc2-3)[nH]1.COC(=O)N[C@H](C(=O)O)C1C[C@@H](C)O[C@H](C)C1>>CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1[C@@H](C)CC[C@H]1c1ncc(-c2ccc3c(c2)COc2cc4c(ccc5nc([C@@H]6CC[C@H](C)N6C(=O)[C@@H](NC(=O)OC)C6C[C@@H](C)O[C@H](C)C6)[nH]c54)cc2-3)[nH]1,Cl,CO,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20010053788A1,N=C(N)N1CC(c2ccccc2)C(c2ccc(Cl)cc2)=N1.O=C(Cl)c1cccc2ccccc12>>N=C(NC(=O)c1cccc2ccccc12)N1CC(c2ccccc2)C(c2ccc(Cl)cc2)=N1,,CC#N,CCOC(C)=O,CCN(CC)CC,[Na+].[OH-],val
US04024248,C1COCCO1.C1COCCO1.CCN1CCOCC1.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO.CN(C)C=O.NNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)CCC(=O)O>>CC(=O)CC(=O)O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)CCC(=O)O,,C1COCCO1,CN(C)C=O,Cl,Cl,val
US20120214767A1,COC(=O)c1snc(-c2ccccc2)c1I.N#C[Cu]C#N>>COC(=O)c1snc(-c2ccccc2)c1C#N,,CCOC(C)=O,CN1CCCC1=O,,,val
US04018930,C1=Cc2cccc3ccn(c23)-c2ccccc21.CC1(CCCCl)OCCO1.CCN(CC)CC.CN(C)C=O>>CC(=O)CCCC1CCC2C(C=CC3=CCCc4c3n2c2ccncc42)C1,,CN(C)C=O,O,[I-].[K+],,val
US20060178381A1,COC(=O)c1cc(F)c(C(F)(F)F)cc1C(=O)OC>>OCc1cc(F)c(C(F)(F)F)cc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030065170A1,NS(=O)(=O)c1c(Cl)cccc1Cl.O=[N+]([O-])O>>NS(=O)(=O)c1c(Cl)ccc([N+](=O)[O-])c1Cl,,O=S(=O)(O)O,,O,,val
US20050107347A1,COC(=O)C(O)Cc1cc(Br)c(Oc2cc(/C=C/c3ccncc3)c(O)c(C(C)C)c2)c(Br)c1>>COC(=O)C(O)Cc1cc(Br)c(Oc2cc(CCc3ccncc3)c(O)c(C(C)C)c2)c(Br)c1,O=[Pt]=O,CO,,,,val
US20070232669A1,O=C(O)c1ccc2c(c1)nnn2-c1ccc(OCc2ccccc2)cc1>>O=C(O)c1ccc2c(c1)nnn2-c1ccc(O)cc1,,C1CCOC1,,O,,val
US20150094439A1,C=C(C)C(=O)Cl.NCCc1ccc([N+](=O)[O-])cc1>>C=C(C)C(=O)NCCc1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,O,Cl,O=C([O-])O.[Na+],val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cc1c(C)n(C)c2ccc(N)cc12>>COc1ccc2nc(Nc3ccc4c(c3)c(C)c(C)n4C)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US20070185089A1,O=C(OCc1ccccc1)N1CC=C(c2ccc3c(c2)CCN(C2CCC2)CC3)CC1>>c1cc2c(cc1C1CCNCC1)CCN(C1CCC1)CC2,[Pd],CCO,,,,val
US20130281640A1,CC(C)C(c1ccc(O)cc1)c1ccc(O)cc1.CCN(CC)CC.ClCCl.N#CCl>>CC(C)C(c1ccc(OC#N)cc1)c1ccc(OC#N)cc1,,C1CCOC1,ClCCl,,,val
US20120214837A1,CCCNc1nc2ccc(OC)cc2cc1C=O>>CCCNc1nc2ccc(OC)cc2cc1CO,,C1CCOC1,,,,val
US20030130517A1,COc1ccc(-c2c(Cl)c(CN)nc3sc4c(c23)CCS(=O)C4)cc1>>COc1ccc(-c2c(Cl)c(CN)nc3sc4c(c23)CC[S@](=O)C4)cc1,,CO,,,,val
US20150087626A1,CC1(C)C[C@H](C(=O)OCc2ccccc2)N(C(=O)OC(C)(C)C)C1>>CC1(C)C[C@H](C(=O)O)N(C(=O)OC(C)(C)C)C1,,C1COCCO1,O,[Li]O,,val
US06218579B1,CS(=O)(=O)c1ccc(C(=O)n2cncn2)c([N+](=O)[O-])c1.O=C1CCCC(=O)C1>>CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c([N+](=O)[O-])c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040014776A1,NCCCN1CCOCC1.O=S(=O)(Cl)c1ccc(I)cc1>>O=S(=O)(NCCCN1CCOCC1)c1ccc(I)cc1,,ClCCl,,CCN(CC)CC,O,val
US20010056094A1,COC(=O)CC(=O)OC.COc1ccccc1-c1ccc(F)c([N+](=O)[O-])c1>>COC(=O)C(C(=O)OC)c1ccc(-c2ccccc2OC)cc1[N+](=O)[O-],,CS(C)=O,,[H-].[Na+],,val
US20150087644A1,COc1c(C)cnc(/C=C/c2cccc(N3CCCC3)n2)c1C>>COc1c(C)cnc(CCc2cccc(N3CCCC3)n2)c1C,[Pd],CCO,,,,val
US20090118357A1,COC(=O)c1cc([N+](=O)[O-])ccc1OC.NO>>COc1ccc([N+](=O)[O-])cc1C(=O)NO,,CO,,Cl,[K+].[OH-],val
US20110136834A1,CC(=O)OC[C@H]1O[C@@H](n2cnc3c(Br)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21.CCCC[Sn](CCCC)(CCCC)c1ccco1>>CC(=O)OC[C@H]1O[C@@H](n2cnc3c(-c4ccco4)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US20110257151A1,COC(=O)c1ccc2c(c1)CC(C)(C)C(c1cccc(S(=O)(=O)NC(C)C)c1)N2>>CC(C)NS(=O)(=O)c1cccc(C2Nc3ccc(C(=O)O)cc3CC2(C)C)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20110312969A1,CC(C)(C)OC(=O)N1CCNCC1.O=Cc1ccccc1-c1ccccc1>>CC(C)(C)OC(=O)N1CCN(Cc2ccccc2-c2ccccc2)CC1,,ClCCl,,CC(=O)O,[Na+].[OH-],val
US20050043544A1,CCOC(C)=O.Cc1c(C=O)ncn1C(c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)CC(O)c1ncn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c1C,,C1CCOC1,C1CCOC1,Cl,,val
US05447957,COC(=O)c1ccc(OC)cc1O.O=[N+]([O-])c1cc(C(F)(F)F)ccc1Cl>>COC(=O)c1ccc(OC)cc1Oc1ccc(C(F)(F)F)cc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050009799A1,C=C(C(=C)c1ccc(OC)cc1)c1ccc(OC)cc1.O=C1C=CC(=O)O1>>COc1ccc(C2=C(c3ccc(OC)cc3)CC3C(=O)OC(=O)C3C2)cc1,,CCOC(C)=O,Cc1ccccc1,,,val
US20140364432A1,C[C@@H]1CCCN[C@@H]1CO.Cc1ccc(-n2nccn2)c(C(=O)O)c1>>Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CO)c1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20010021718A1,C1COCCN1.CCOC(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1>>CC(C)(C)OC(=O)C[C@@H](CCCC1CCCCC1)c1nc(C(=O)N2CCOCC2)no1,,CCO,,,,val
US20100173933A1,COc1cccc(-c2ccc3sc(COc4ccc(F)c(C(N)=O)c4F)nc3c2)c1>>NC(=O)c1c(F)ccc(OCc2nc3cc(-c4cccc(O)c4)ccc3s2)c1F,,ClCCl,,BrB(Br)Br,O,val
US20130281431A1,CC(CN)c1ccnc2c1OCC2.Clc1cc(Cl)ncn1>>CC(CNc1cc(Cl)ncn1)c1ccnc2c1OCC2,,CC(C)O,,CCN(CC)CC,CCOC(C)=O,val
US20090163520A1,CC(C)(C)OC(=O)NN.N#Cc1ccc(I)cc1>>CC(C)(C)OC(=O)N(N)c1ccc(C#N)cc1,I[Cu]I,CN(C)C=O,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US04009208,O=C(NCC/C=C/CCCNC(=O)c1ccc(OC(F)(F)F)cc1)c1ccc(OC(F)(F)F)cc1.O=C(OO)c1cccc(Cl)c1>>O=C(N/C=C/C1OC1CCCNC(=O)c1ccc(OC(F)(F)F)cc1)c1ccc(OC(F)(F)F)cc1,,ClC(Cl)Cl,,,,val
US20090137595A1,Cc1cc(C(=O)O)nn1-c1ccccc1.Nc1cccc(Sc2ccc3nc(NC(=O)C4CC4)cn3n2)c1>>Cc1cc(C(=O)Nc2cccc(Sc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)nn1-c1ccccc1,,C1CCOC1,CC(=O)N(C)C,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20100249118A1,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)O)c1F.O=S(Cl)Cl>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Cl)c1F,,Cc1ccccc1,,,,val
US20070027155A1,COCc1nc(Cl)cc(N2CCN(c3ncccc3C(F)(F)F)CC2)n1.OB(O)c1cccc(Cl)c1>>COCc1nc(-c2cccc(Cl)c2)cc(N2CCN(c3ncccc3C(F)(F)F)CC2)n1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20140148454A1,CI.O=C(O)c1ncc(Cl)nc1Cl>>COC(=O)c1ncc(Cl)nc1Cl,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100137361A1,COC1=Cc2c(cccc2[N+](=O)[O-])N(C)C1>>CN1CC(=O)Cc2c1cccc2[N+](=O)[O-],,C1CCOC1,,Cl,[Na],val
US05578636,CCCCCCCCCCCCCCCC(=O)Cl.OCCC#Cc1ccc(-c2cccs2)s1>>CCCCCCCCCCCCCCCCOCCC#Cc1ccc(-c2cccs2)s1,,c1ccncc1,,,,val
US20130096303A1,CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1CO.CS(=O)(=O)Cl>>CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1CCl,,O,,CCN(CC)CC,ClCCl,val
US20030176450A1,NCc1cccs1.O=C(O)c1cc2nc(-c3ccc(Br)cc3)cc(C(F)(F)F)n2n1>>O=C(NCc1cccs1)c1cc2nc(-c3ccc(Br)cc3)cc(C(F)(F)F)n2n1,,C1CCOC1,CCOCC,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20140275003A1,O=[N+]([O-])c1cc(Cl)nc(Cl)c1.OCc1ccccc1>>Clc1cc(OCc2ccccc2)cc(Cl)n1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20020165365A1,CC(C)(C)OC(=O)N1CCN(CCCN)CCN(C(=O)OC(C)(C)C)CCN(C(=O)OC(C)(C)C)CC1.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21>>CC(C)(C)OC(=O)N1CCN(CCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@@H]32)CCN(C(=O)OC(C)(C)C)CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150291632A1,Fc1ccc(CCC2(c3ccc(Oc4ccc(Cl)cn4)cn3)CO2)c(F)c1.c1nnn[nH]1>>OC(CCc1ccc(F)cc1F)(Cn1cnnn1)c1ccc(Oc2ccc(Cl)cn2)cn1,,CS(C)=O,,CC(C)NC(C)C,,val
US04413006,COc1cc(NC(C)=O)ccc1OCCCN1CCN(c2ccccc2)CC1>>COc1cc(N)ccc1OCCCN1CCN(c2ccccc2)CC1,,Cl,,[Na+].[OH-],,val
US20120294835A1,COc1ccc(Nc2cc(Cl)ncn2)cc1.NCC(=O)O>>COc1ccc(Nc2cc(NCC(=O)O)ncn2)cc1,,Cl,,CCN(C(C)C)C(C)C,,val
US20160039821A1,CCOC(=O)c1cc2c(Br)cnc(OC)c2n1Cc1ccccc1>>CCOC(=O)c1cc2c(Br)c[nH]c(=O)c2n1Cc1ccccc1,,C1COCCO1,,Cl,,val
US05405989,C#CCO.O=C(Cl)CCCCCCCc1ccccc1>>C#CCOC(=O)CCCCCCCc1ccccc1,,Cc1ccccc1,,c1ccncc1,,val
US05110812,CCS[C@H]1[C@H](CCCNC(=NC(=O)OCc2ccccc2)NC(=O)OCc2ccccc2)C(=O)N1C(C)=O.Cl>>CCS[C@H]1[C@H](CCCNC(=N)N)C(=O)N1C(C)=O.Cl,[Pd],CCOC(C)=O,CO,,,val
US20040235839A1,Cc1cncc2[nH]c3ccccc3c12.O=C1CCC(=O)N1Cl>>Cc1cncc2[nH]c3ccc(Cl)cc3c12,,Cl,,O=C([O-])O.[Na+],,val
US20110294807A1,CC(C)(C)[Si](C)(C)OCCBr.CCC(C)c1ccc(-n2c(-c3cc(C)c(O)c(C)c3)nc3ccccc3c2=O)cc1>>CCC(C)c1ccc(-n2c(-c3cc(C)c(OCCO[Si](C)(C)C(C)(C)C)c(C)c3)nc3ccccc3c2=O)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120178913A1,C=CCCl.COC(=O)[C@H](CS)NC(=O)OC(C)(C)C>>C=CCSC[C@H](NC(=O)OC(C)(C)C)C(=O)OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080058384A1,COC(=O)C1=C(C)N(C)C(=O)CC1c1ccc(C(F)(F)F)cc1F>>CC1=C(C(=O)O)C(c2ccc(C(F)(F)F)cc2F)CC(=O)N1C,,C1CCOC1,,,,val
US06362177B1,Cc1ccc(CN2CCC(CNC(=O)CNC(=O)c3cc(F)c(F)cc3N)CC2)cc1[N+](=O)[O-]>>Cc1ccc(CN2CCC(CNC(=O)CNC(=O)c3cc(F)c(F)cc3N)CC2)cc1N,[Pd],CO,,,,val
US20110082138A1,Brc1cnc2[nH]ccc2c1I.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c(I)c(Br)cnc32)cc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US05290788,ClCc1ccc2ccccc2n1.Oc1ccc2[nH]ccc2c1>>c1ccc2nc(COc3ccc4[nH]ccc4c3)ccc2c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120220552A1,CC(C)(C)OC(=O)CCN1CCOC(c2ccc(OCc3c(Cl)cccc3Cl)cc2)C1.Cl>>Cl.O=C(O)CCN1CCOC(c2ccc(OCc3c(Cl)cccc3Cl)cc2)C1,,Cl,,C1COCCO1,,val
US20040082542A1,O=[N+]([O-])c1ccc(Oc2ccc(F)c(C(F)(F)F)c2)cc1>>Nc1ccc(Oc2ccc(F)c(C(F)(F)F)c2)cc1,[Pd],CO,,,,val
US20040067998A1,COC(=O)c1cccc2[nH]ccc12.Fc1ccc(CCl)cc1>>COC(=O)c1cccc2c1ccn2Cc1ccc(F)cc1,,CN(C)C=O,,[H][H],[H-].[Na+],val
US20100234367A1,Brc1cccnc1.CCOC1=CC(=O)CCC1>>O=C1C=C(c2cccnc2)CCC1,,CCOCC,,Cl,[Li]CCCC,val
US20080171769A1,CCN1CCC(N2C(=O)c3cc4nc(-c5c(Cl)cc[nH]c5=O)[nH]c4cc3C2=O)CC1.Cc1ccc(OC[C@H](O)CN)c(C)c1>>CCN1CCC(N2C(=O)c3cc4nc(-c5c(NC[C@@H](O)COc6ccc(C)cc6C)cc[nH]c5=O)[nH]c4cc3C2=O)CC1,,CCO,,CCN(CC)CC,,val
US20070032531A1,Nc1nc2cc(Cl)ccc2o1.O=C(Cl)c1ccccc1[N+](=O)[O-]>>O=C(Nc1nc2cc(Cl)ccc2o1)c1ccccc1[N+](=O)[O-],,c1ccccc1,,,,val
US20150232481A1,C=CC[C@@H](C)O.O=Cc1cc(F)c(F)cc1O>>C=CC[C@H](C)Oc1cc(F)c(F)cc1C=O,,C1CCOC1,CCOCC,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030149001A1,CCOC(=O)c1cc2cnc(SC)nc2n(C2CCCC2)c1=O.O=S(=O)(c1ccccc1)N1OC1c1ccccc1>>CCOC(=O)c1cc2cnc(S(C)=O)nc2n(C2CCCC2)c1=O,,ClCCl,,,,val
US04161611,COS(=O)(=O)OC.O=C(O)c1c(Cl)ccc(Cl)c1O>>COc1c(Cl)ccc(Cl)c1C(=O)O,,O,,Cl,[K+].[OH-],val
US06399629B1,COC(=O)[C@@H]1C[C@H](OS(C)(=O)=O)CN1C(=O)CN(C)C(=O)OC(C)(C)C.[N-]=[N+]=[N-]>>COC(=O)[C@@H]1C[C@@H](N=[N+]=[N-])CN1C(=O)CN(C)C(=O)OC(C)(C)C,,CN(C)C=O,,O,,val
US20050282827A1,NCC1CC1.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1>>O=[N+]([O-])c1cccc(S(=O)(=O)NCC2CC2)c1,,C1COCCO1,,CCN(CC)CC,O,val
US08129361B2,N#Cc1cccc(CCCO)c1.O=C1CCC(=O)N1Br>>N#Cc1cccc(CCCBr)c1,,ClCCl,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080125468A1,CCCC[Mg]Br.O=Cc1ccc(-c2ccc(C(F)(F)F)cn2)cc1>>CCCCC(O)c1ccc(-c2ccc(C(F)(F)F)cn2)cc1,,C1CCOC1,,,,val
US20080167305A1,CCOC(=O)N[C@@H]1CCN(c2nc(-c3ccccc3O)nc3cc(C)ccc23)C1.Cl>>CCOC(=O)N[C@@H]1CCN(c2nc(-c3ccccc3O)nc3cc(C)ccc23)C1.Cl,,ClCCl,,CCOCC,,val
US20040077669A1,CC#CCO.Clc1cc(Cc2ccccc2Br)ncn1>>CC#CCOc1cc(Cc2ccccc2Br)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US06133253,Cc1ccc(S(=O)(=O)OC[C@H]2CCN2C(=O)OC(C)(C)C)cc1.Oc1cncc(Cl)c1>>CC(C)(C)OC(=O)N1CC[C@@H]1COc1cncc(Cl)c1,,CN(C)C=O,,[K+].[OH-],,val
US20150119362A1,CN(C(N)=O)c1ccc(N)cc1.Clc1cccc(-c2cc(Cl)c3c(n2)CCC3)c1>>CNc1ccc(Nc2cc(-c3cccc(Cl)c3)nc3c2CCC3)cc1,Cl,CN1CCCC1=O,O,O=C([O-])O.[Na+],,val
US20120101079A1,CC(C)[Mg]Cl.Cc1cc(N2CCOCC2)nc(Cl)c1C(=O)NCc1cccc(F)c1>>Cc1cc(N2CCOCC2)nc(C(C)C)c1C(=O)NCc1cccc(F)c1,,C1CCOC1,CN1CCCC1=O,[Cl-].[NH4+],,val
US20150329557A1,CCOC(=O)C1Cc2cc(Br)ccc2C1=O>>CCOC(=O)C1Cc2ccc(Br)cc2C1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20070185152A1,Cc1n[nH]c2ccc(B3OC(C)(C)C(C)(C)O3)cc12.Oc1cnc(Cl)c(Br)c1>>Cc1n[nH]c2ccc(-c3cc(O)cnc3Cl)cc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20020120142A1,C1COCCO1.Cc1ccccc1S(=O)(=O)OCCCOS(=O)(=O)c1ccccc1C.Nc1cccc(O)c1>>Oc1ccc2c3c1CCCN3CCC2,,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20050215577A1,CCOC(=O)CBr.Sc1cccc(Cl)c1>>COC(=O)CSc1cccc(Cl)c1,,CN(C)C=O,,[H-].[Na+],,val
US20090163508A1,CC(C)(C)OC(=O)N1CCN(c2cc(Cl)ncn2)CC1.OB(O)Oc1cccc(F)c1>>CC(C)(C)OC(=O)N1CCN(c2cc(-c3cccc(F)c3)ncn2)CC1,,O,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20040152743A1,Cc1nnc(-c2ccccc2[N+](=O)[O-])n1-c1ccccc1C(=O)O>>Cc1nnc(-c2ccccc2N)n1-c1ccccc1C(=O)O,[Pd],C1CCOC1,,,,val
US20130165436A1,Brc1ccc(Br)nc1.CC[S-]>>CCSc1ccc(Br)cn1,,CS(C)=O,,O,,val
US20070072862A1,CNc1ncc([N+](=O)[O-])c(N)n1>>CNc1ncc(N)c(N)n1,[Pd],CO,,[H][H],,val
US20110212918A1,Nc1cc2c(cc1F)COB2O.Nc1ccc(S(=O)(=O)Cl)cn1>>Nc1ccc(S(=O)(=O)Nc2cc3c(cc2F)COB3O)cn1,,CC#N,,c1ccncc1,,val
US20100152463A1,O=C(O)C(F)(F)F.O=S(c1ccccc1)N(CCF)Cc1ccccc1>>FCCNCc1ccccc1.O=C(O)C(F)(F)F,,CO,,,,val
US03983107,C1CCNCC1.CC(=Cc1ccccc1)S(=O)(=O)NC(=O)N(c1ccccc1)c1ccccc1>>CC(=Cc1ccccc1)S(=O)(=O)NC(=O)N1CCCCC1,,CCOCC,,CN(C)C=O,,val
US20140349993A1,CCOC(=O)c1cnc2c(C)cc(-c3ccccc3C(F)(F)F)nn12>>Cc1cc(-c2ccccc2C(F)(F)F)nn2c(C(=O)O)cnc12,,C1CCOC1,O,[Na+].[OH-],,val
US20070093484A1,CCOC(=O)c1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)nc1Cn1ncnn1.NN1CCCCC1>>O=C(NN1CCCCC1)c1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)nc1Cn1ncnn1,,ClCCl,,C[Al](C)C,Cl,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n([C@@H]2CC[C@@H](OC(C)C(C)(C)O)CC2)c2nc(C)nn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2F)c(=O)n([C@@H]2CC[C@@H](OC(C)C(C)(C)O)CC2)c2nc(C)nn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20150087646A1,CC(C)(C)OC(=O)NNc1cc(CNC(=O)C(F)(F)F)c(F)cc1Cl.O=C=NC(=O)c1ccc(I)cc1>>O=C(NCc1cc(-n2nc(-c3ccc(I)cc3)[nH]c2=O)c(Cl)cc1F)C(F)(F)F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100286118A1,CC(C)(C)OC(=O)NC1(C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)[nH]c4c3)cc2)CCOCC1>>N#C[C@H](Cc1ccc(-c2ccc3oc(=O)[nH]c3c2)cc1)NC(=O)C1(N)CCOCC1,,O,O=CO,N,,val
US20130116243A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)NC(=S)CO4)cc2)CCC1.NN>>CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)NC(=NN)CO4)cc2)CCC1,,C1CCOC1,,O,,val
US20130101841A1,BrCc1ccccc1.C1=CN2CCCNC2CCC1>>c1ccc(CN2CCCN3CCCCCC32)cc1,,Cc1ccccc1,,,,val
US20130150343A1,CC(C)(C)OC(=O)N1CC[C@@H](C(=O)O)C1.NNc1ccc(F)cn1>>CC(C)(C)OC(=O)N1CC[C@@H](C(=O)N(N)c2ccc(F)cn2)C1,,ClCCl,O,ClCCCl,On1nnc2ccccc21,val
US04006145,N#Cc1cc(C(F)(F)F)ccc1Sc1ccccc1.O.[OH-]>>O=C(O)c1cc(C(F)(F)F)ccc1Sc1ccccc1,,O,,CCO,,val
US20060014816A1,C#CCBr.Nc1ncccn1>>C#CCNc1ncccn1,,CCO,,,,val
US20100298336A1,CCI.Cc1nc[nH]c1C=O>>CCn1cnc(C)c1C=O,,C1CCOC1,,O,,val
US20050004150A1,CC(=O)O.CC(=O)c1nc(CBr)cs1>>CC(=O)OCc1csc(C(C)=O)n1,,CCOC(C)=O,,CC(=O)[O-].[K+],,val
US20040138277A1,CCOC(=O)C(C)Br.Cc1ccc(O)cc1>>CCOC(=O)C(C)Oc1ccc(C)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100121052A1,C#Cc1ccc2nc(Nc3cc(O[C@H]4CCNC4)cc(-c4cnn(C)c4)c3)ncc2c1.OCCBr>>C#Cc1ccc2nc(Nc3cc(O[C@H]4CCN(CCO)C4)cc(-c4cnn(C)c4)c3)ncc2c1,,CN(C)C=O,,CCN(CC)CC,,val
US20140329807A1,CCOC(C)=O.COC(=O)[C@@H]1CC[C@@H](CN)CC1.C[Mg]Br>>CC(C)(O)[C@@H]1CC[C@@H](CN)CC1,,C1CCOC1,,,,val
US20090131458A1,CCC(C)COc1nc(N)c2nc(Br)n(C3CCCCO3)c2n1.CO>>CCC(C)COc1nc(N)c2nc(OC)n(C3CCCCO3)c2n1,,CO,,C[O-].[Na+],,val
US20040024261A1,CCOC(=O)C[C@H](O)COC(c1ccccc1)(c1ccccc1)c1ccccc1>>OCC[C@H](O)COC(c1ccccc1)(c1ccccc1)c1ccccc1,,CCO,O,CC(=O)O,[BH4-].[Na+],val
US20140141034A1,C#CCOCC(CNC(=O)OC(C)(C)C)OCC#C>>C#CCOCC(CN)OCC#C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110015431A1,CCOC(=O)CCCC(F)(F)C(F)(F)Br>>CCOC(=O)CCCC(F)(F)C(F)F,,C1CCOC1,,CO,[BH4-].[Na+],val
US20130225602A1,CCn1cc(N2CCN(C(=O)OC(C)(C)C)CC2=O)c2ccc(OCc3ccccn3)nc21>>CCn1cc(N2CCNCC2=O)c2ccc(OCc3ccccn3)nc21,,CO,ClCCl,O=C(O)C(F)(F)F,,val
US05708008,Nc1ccc2[nH]ccc2c1.O=C(Cl)c1ccco1>>O=C(Nc1ccc2[nH]ccc2c1)c1ccco1,,C1CCOC1,,CCN(CC)CC,,val
US06177440B1,COC(=O)COc1cccc2c1c1c(C(N)=O)cccc1n2Cc1c(Cl)cccc1Cl>>NC(=O)c1cccc2c1c1c(OCC(=O)O)cccc1n2Cc1c(Cl)cccc1Cl,,CCO,,[Na+].[OH-],,val
US05235063,Nc1ccc(OCc2ccccc2)cc1.OC[C@@H]1CO1>>OCC(O)CNc1ccc(OCc2ccccc2)cc1,,CCO,,CO,,val
US20160039811A1,CCOC(=O)c1c(Br)nn(C)c1N1CC[C@H](O)C1.CI>>CCOC(=O)c1c(Br)nn(C)c1N1CC[C@H](OC)C1,,O,,CN(C)C=O,[H-].[Na+],val
US20070276152A1,CCOCC.CO.ClCCl.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1>>CC(C)=CCCC1(C)CC1C=O,,ClCCl,,,,val
US20160016908A1,CC(=O)N1c2ccc(C(N)=O)cc2[C@H](Nc2ccccc2N2CCN(C(=O)OC(C)(C)C)CC2)[C@@H](C)[C@@H]1C1CC1>>CC(=O)N1c2ccc(C(N)=O)cc2[C@H](Nc2ccccc2N2CCNCC2)[C@@H](C)[C@@H]1C1CC1,,C1COCCO1,,Cl,,val
US20050010048A1,COCCOCOc1c(Br)cc(C)c2cccnc12.CON(C)C(=O)c1cccc(Cc2ccccc2)c1>>COCCOCOc1c(C(=O)c2cccc(Cc3ccccc3)c2)cc(C)c2cccnc12,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20090264650A1,COc1cc(Cl)cc(Cl)c1C(O)C1CCN(C2CCCCC2)C1=O>>COc1cc(Cl)cc(Cl)c1CC1CCN(C2CCCCC2)C1=O,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20100331293A1,Cc1c(Cl)nc2cc(F)cc(F)c2c1Cl.OB(O)c1ccc(C(F)(F)F)cc1C(F)(F)F>>Cc1c(-c2ccc(C(F)(F)F)cc2C(F)(F)F)nc2cc(F)cc(F)c2c1Cl,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20070105831A1,COc1ccc(Cl)c(OC2CN(C(C)(C)CCC(C(N)=O)(c3ccccc3)c3ccccc3)C2)c1>>CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cc(O)ccc2Cl)C1,,ClCCl,,BrB(Br)Br,,val
US20110053916A1,CC(=O)OC(C)=O.CCOC(=O)c1cnc(Br)nc1Nc1cc(C2CC2)[nH]n1>>CCOC(=O)c1cnc(Br)nc1Nc1cc(C2CC2)n(C(C)=O)n1,,C1CCOC1,O,,,val
US05162308,CCI.N#Cc1c(Br)[nH]c(Br)c1Br>>CCn1c(Br)c(Br)c(C#N)c1Br,,C1CCOC1,O,CC(C)(C)[O-].[K+],,val
US05232940,CC(=O)Cl.Nc1cc(Br)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl>>CC(=O)Nc1cc(Br)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl,,ClC(Cl)Cl,,c1ccncc1,,val
US20060211693A1,CCOc1cc(Cl)c(S(=O)(=O)NC)cc1C1=N[C@@H](c2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)N1C(=O)On1nnc2ccccc21.O=C(CN1CCNCC1)N1CCOCC1>>CCOc1cc(Cl)c(S(=O)(=O)NC)cc1C1=N[C@@H](c2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)N1C(=O)N1CCN(CC(=O)N2CCOCC2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04405518,C#CCBr.Cc1[nH]cc2c1-c1ccc(Cl)cc1C(c1ccccc1F)=NC2>>C#CCc1[nH]c(C)c2c1CN=C(c1ccccc1F)c1cc(Cl)ccc1-2,,C1CCOC1,Cc1ccccc1,O,CC(C)[N-]C(C)C.[Li+],val
US04443451,Cc1nc2scc(C)n2c(=O)c1CCCl.c1ccc2c(C3CCNCC3)c[nH]c2c1>>Cc1nc2scc(C)n2c(=O)c1CCN1CCC(c2c[nH]c3ccccc23)CC1,,CC(=O)CC(C)C,O,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US04175131,CCCCCCN=C=O.CCCCNc1nc(C)co1>>CCCCCCNC(=O)N(CCCC)c1nc(C)co1,,c1ccccc1,,,,val
US20010044445A1,CCO.Nc1nnn[nH]1.O=[N+]([O-])c1ccc(NN=C(Cl)C(F)(F)F)cc1>>Nc1cc(C(F)(F)F)nn1-c1ccc([N+](=O)[O-])cc1,,CCO,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20150045575A1,CC(C)C[C@H](NF)C(=O)O.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>CC(C)C[C@H](NF)C(=O)O.O=C(O)[C@H](O)[C@@H](O)C(=O)O,,CCO,,COC(C)(C)C,,val
US20060094708A1,CC(C)I.COC(=O)c1ccc(O)c(C#N)c1>>COC(=O)c1ccc(OC(C)C)c(C#N)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130053407A1,CCOC(=O)CCNC(=O)Nc1cc(Cl)n(-c2ccc(-c3cccc(OC)c3O)cc2)c1C(=O)OCC>>COc1cccc(-c2ccc(-n3c(Cl)cc4[nH]c(=O)n(CCC(=O)O)c(=O)c43)cc2)c1O,,CCO,,[Na],,val
US20110003807A1,COC(=O)C(Cl)C(=O)OC.Cc1nn2ccc(OCc3ccccc3)cc2c1C(N)=S>>COC(=O)c1sc(-c2c(C)nn3ccc(OCc4ccccc4)cc23)nc1O,,CN(C)C=O,,Cl,O,val
US20040214855A1,CCOC(=O)c1nc(-c2ccc(Cl)cc2)n(-c2ccccc2F)c1C=O.NC1CCCC1>>CCOC(=O)c1nc(-c2ccc(Cl)cc2)n(-c2ccccc2F)c1CNC1CCCC1,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160130278A1,CCn1cc(B2OC(C)(C)C(C)(C)O2)cn1.O=C(NC(c1cccc(Br)c1)C1(O)CCC(F)(F)CC1)c1nccc(C(F)(F)F)c1Cl>>CCn1cc(-c2cccc(C(NC(=O)c3nccc(C(F)(F)F)c3Cl)C3(O)CCC(F)(F)CC3)c2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US04179505,CC(=O)Cl.Cn1c(N)nc2cc(CN3CCN(C(c4ccccc4)c4ccccc4)CC3)ccc21>>CC(=O)Nc1nc2cc(CN3CCN(C(c4ccccc4)c4ccccc4)CC3)ccc2n1C,,c1ccncc1,,[NH4+].[OH-],,val
US20090298807A1,CC(C)(C)[Si](C)(C)OCCCCCCBr.CCOC(=O)C(C)C>>CCOC(=O)C(C)(C)CCCCCCO[Si](C)(C)C(C)(C)C,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20030096826A1,CCOC(=O)C(C(=O)OCC)c1ccnc2ccccc12>>CCOC(=O)Cc1ccnc2ccccc12,,CS(C)=O,,O,[Cl-].[Na+],val
US20080234250A1,COC(=O)c1cccc(F)c1NC(=O)OC(C)(C)C.O=C(NCCBr)OCc1ccccc1>>CC(C)(C)OC(=O)N(CCNC(=O)OCc1ccccc1)c1c(F)cccc1C(=O)O,,CN(C)C=O,,[H-].[Na+],,val
US06018052,CC(N=C=S)(C(=O)[O-])c1ccccc1.NNc1ccccc1>>CC1(c2ccccc2)NC(=S)N(c2ccccc2)C1=O,,Cc1ccccc1C,,CCOCC,,val
US06323235B1,BrCc1ccccc1.Oc1cccc2[nH]ccc12>>c1ccc(COc2cccc3[nH]ccc23)cc1,,CN(C)C=O,,[K+].[OH-],,val
US20060100246A1,CC(C)(C)OC(=O)N1CCCC(c2cc(-c3ccccc3OCc3ccccc3)nc(Br)c2C#N)C1.NCc1ccccc1>>CC(C)(C)OC(=O)N1CCCC(c2cc(-c3ccccc3OCc3ccccc3)nc(NCc3ccccc3)c2C#N)C1,,CS(C)=O,,CCN(CC)CC,,val
US20050107449A1,CCOC(=O)CC(=O)C(Br)CC.NC(=S)c1ccc(C(F)(F)F)cc1>>CCOC(=O)Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CC,,CCO,,,,val
US20020137946A1,CC(=O)Nc1cc(NS(=O)(=O)CCl)c(Cl)cc1F>>Nc1cc(NS(=O)(=O)CCl)c(Cl)cc1F,,Cl,,[Na+].[OH-],,val
US20130190316A1,COc1cc(C=O)c(OCc2cncc(C(=O)[O-])c2)cn1>>COc1cc(C=O)c(OCc2cncc(C(=O)O)c2)cn1,,C1CCOC1,CO,[Na+].[OH-],,val
US20090306016A1,CCCCCCC(C)(C)c1cc(OCOC)cc(OCOC)c1.COB(OC)OC>>CCCCCCC(C)(C)c1cc(OCOC)c(B(O)O)c(OCOC)c1,,C1CCOC1,O,Cl,[Li]CCCC,val
US20100210690A1,COC(=O)c1cc(OCCc2ccsc2)cc(OC(C)C)c1>>CC(C)Oc1cc(OCCc2ccsc2)cc(C(=O)O)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20040242659A1,CC(C)(C)Oc1ccc(CCCCn2ccnc2CCO)cc1.CS(=O)(=O)Cl>>CC(C)(C)Oc1ccc(CCCCn2ccnc2CCOS(C)(=O)=O)cc1,,CCOC(C)=O,,CCN(CC)CC,O,val
US20050075352A1,N#Cc1c(NCc2ccccc2)cccc1-c1ccccc1>>NCc1c(NCc2ccccc2)cccc1-c1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US04755535,O=C1NCCCCC1(Br)Br>>O=C1NCCCCC1Br,[Pd],CC(=O)O,,CC(=O)[O-].[Na+],,val
US20110059545A1,CC(=O)O.CC(=O)OCc1c2ccccc2c(COC(C)=O)c2ccccc12>>O=Cc1ccccc1O,,ClC(Cl)Cl,ClCCl,,,val
US20090023759A1,ClCc1ccccn1.Fc1cccc2ncnc(Nc3ccc4[nH]ccc4c3)c12>>Fc1cccc2ncnc(Nc3ccc4c(ccn4Cc4ccccn4)c3)c12,,CN(C)C=O,,Cl,[H-].[Na+],val
US20070032489A1,CCc1cc(-c2ccc(C=O)s2)c(C)[nH]c1=O>>CCc1cc(-c2ccc(CO)s2)c(C)[nH]c1=O,,CO,,[BH4-].[Na+],,val
US20030171578A1,C=C1CCN(c2ccc(Cl)cc2)C1=O.COCCN1CCNCC1>>COCCN1CCN(CC2CCN(c3ccc(Cl)cc3)C2=O)CC1,,CC#N,,,,val
US20100152163A1,CC(C)NC(=O)CCl.CN1CCc2[nH]c3ccc(Cl)cc3c2CC1>>CC(C)NC(=O)Cn1c2c(c3cc(Cl)ccc31)CCN(C)CC2,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20110028501A1,COc1ccc(C(C=O)C=O)cc1.NO>>COc1ccc(-c2cnoc2)cc1,,CCO,,Cl,,val
US20060276465A1,CCCCN1CCN(c2ccc(CN3CCOCC3)cc2C2CC(C)(C)CC(C)(C)C2)CC1.Cl.ClCCl>>CCCCN1CCN(c2ccc(CN3CCOCC3)cc2C2CC(C)(C)CC(C)(C)C2)CC1.Cl.Cl,,CCOC(C)=O,ClCCl,,,val
US20090163572A1,N#Cc1ccc(C=O)cc1.OCc1ccccc1S>>N#Cc1ccc(C2OCc3ccccc3S2)cc1,,ClCCl,,Cl,,val
US20120264735A1,CC(c1cccc([N+](=O)[O-])c1)c1nn(-c2cnn(C)c2)ccc1=O>>CC(c1cccc(N)c1)c1nn(-c2cnn(C)c2)ccc1=O,,CO,,,,val
US20130079383A1,COC(=O)C1(CCN=[N+]=[N-])CCCC1>>[N-]=[N+]=NCCC1(C(=O)O)CCCC1,,C1CCOC1,O,CO,,val
US09012412B2,CI.Cc1c(Cc2cc3ccccc3s2)cc(C2OC(CO)CC(O)C2O)c(O)c1C>>COc1c(C2OC(CO)CC(O)C2O)cc(Cc2cc3ccccc3s2)c(C)c1C,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04367238,C=CCBr.Cc1ccccc1Sc1ccccc1O>>C=CCc1cccc(Sc2ccccc2C)c1O,,CC(=O)CC(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20050267093A1,CCOC(=O)/C=C/c1ccc(Br)cc1.OB(O)Oc1ccc(Cl)cc1>>CCOC(=O)/C=C/c1ccc(-c2ccc(Cl)cc2)cc1,,C1COCCO1,CO,O=C([O-])[O-].[Na+].[Na+],,val
US20020022631A1,CCOC(=O)C(Cc1cncs1)NC(C)=O>>CC(=O)NC(CO)Cc1cncs1,,CCO,,[BH4-].[Na+],,val
US20120238540A1,COc1cc(N)cc(Nc2nccc(-c3ccc(OC)c(C#N)c3)n2)c1.O=C=NC1CCCC1>>COc1cc(NC(=O)NC2CCCC2)cc(Nc2nccc(-c3ccc(OC)c(C#N)c3)n2)c1,,C1CCOC1,CN(C)C=O,CCN(CC)CC,,val
US20070078121A1,C=O.NC(Cc1cccc(O)c1)C(=O)O>>O=C(O)C1Cc2cc(O)ccc2CN1,,Cl,,,,val
US20120157487A1,CCCI.O=Cc1c[nH]cn1>>CCCn1cnc(C=O)c1,,C1CCOC1,,[H-].[Na+],,val
US20140073627A1,CC1(C)CO1.COc1cc(C)c(S(=O)(=O)N(C)Cc2nnc(C(=O)N3CCN(CC4CCNCC4)CC3)o2)c(C)c1>>COc1cc(C)c(S(=O)(=O)N(C)Cc2nnc(C(=O)N3CCN(CC4CCN(CC(C)(C)O)CC4)CC3)o2)c(C)c1,,CN(C)C=O,,,,val
US20090306171A1,COC(=O)C(F)(Oc1cccc2c1cc(C)n2Cc1ccccc1)C(F)(F)Br>>Cc1cc2c(OC(F)(C(=O)O)C(F)(F)Br)cccc2n1Cc1ccccc1,,C1CCOC1,O,[Li+].[OH-],,val
US20040229891A1,Cc1cc(C)c(Nc2nc(C)ncc2S(=O)(=O)c2ccc(O)cc2)c(C)c1.O=S(=O)(Cl)C(F)(F)F>>Cc1cc(C)c(Nc2nc(C)ncc2S(=O)(=O)c2ccc(OS(=O)(=O)C(F)(F)F)cc2)c(C)c1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20090093454A1,O=C1NC(=O)c2c(CCCBr)cccc21.c1cnc2c(c1)CC[C@H]1CCCN(Cc3nc4ccccc4[nH]3)[C@@H]21>>NCCCn1c(CN2CCC[C@@H]3CCc4cccnc4[C@@H]32)nc2ccccc21,,CN(C)C=O,O,CCN(C(C)C)C(C)C,[I-].[K+],val
US20140012000A1,C#Cc1ccccc1.O=C=O>>O=C(O)C#Cc1ccccc1,,O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130210804A1,NC(=NOC(=O)[C@@H]1CC[C@H]2CCc3cc(F)ncc3C(=O)N2C1)c1cc(Cl)c[nH]1>>O=C1c2cnc(F)cc2CC[C@@H]2CC[C@@H](c3nc(-c4cc(Cl)c[nH]4)no3)CN12,,CC(=O)N(C)C,O,,,val
US04343945,Cc1ccc(C(=O)Cl)cc1.Nc1nc(C(Cl)(Cl)Cl)ns1>>Cc1ccc(C(=O)Nc2nc(C(Cl)(Cl)Cl)ns2)cc1,,Cc1ccccc1,,,,val
US03970454,CC(=O)N(C)C.COS(=O)(=O)[O-].Oc1cccc2cccnc12>>COS(=O)(=O)[O-].C[n+]1cccc2cccc(O)c21,,CC(=O)N(C)C,,,,val
US20140243526A1,CC(=O)CCCCC=O>>CC(=O)CCCCCO,,Cc1ccccc1,,,,val
US20080015202A1,CC(=O)Nc1nc(CCc2ccc(CCN)cc2)cs1.C[Si](C)(C)N=C=O>>CC(=O)Nc1nc(CCc2ccc(CCNC(N)=O)cc2)cs1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US05081248,O=C1c2ccccc2C(=O)N1OCc1cc(=O)c(OC(c2ccccc2)c2ccccc2)cn1OC(c1ccccc1)c1ccccc1>>NOCc1cc(=O)c(O)cn1O,,CC(=O)O,,Cl,,val
US07829584B2,II.OCC(F)(F)c1ncccn1>>FC(F)(CI)c1ncccn1,,CC#N,Cc1ccccc1,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100093707A1,CCOCC.Cc1c(Br)ccc2c1OC(F)(F)C(F)(F)O2.O.[Li]CCCC>>Cc1c(C(O)C(C)C)ccc2c1OC(F)(F)C(F)(F)O2,,O,,Cl,,val
US20120208827A1,CN.COc1ccc(-c2ccc(-c3nc4ccc(C(=O)O)cc4n3C[C@@H]3CCN(C(=O)C4CC4)C3)cc2)cc1>>CNC(=O)c1ccc2nc(-c3ccc(-c4ccc(OC)cc4)cc3)n(C[C@@H]3CCN(C(=O)C4CC4)C3)c2c1,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20040224970A1,C1CCC2OC2C1.COc1ccc(-c2cc3c(n2-c2ccccc2Cl)CCNC3)cc1>>COc1ccc(-c2cc3c(n2-c2ccccc2Cl)CCN([C@@H]2CCCC[C@H]2O)C3)cc1,,CCO,,CCN(CC)CC,,val
US20030199440A1,CC(C)[C@H](N)C(=O)OC(C)(C)C.O=S(=O)(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>CC(C)[C@H](NS(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1)C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20080153837A1,ON=C1c2ccccc2-c2c1cccc2-c1nc2ccccc2[nH]1>>NC1c2ccccc2-c2c(-c3nc4ccccc4[nH]3)cccc21,[Ni],C1CCOC1,CCO,,,val
US05302718,COC(=O)c1cc(C=Cc2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O>>O=C(O)c1cc(C=Cc2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O,,[K+],[OH-],Cl,,val
US04698345,CCCc1c(O)c(C(C)=O)cc2c(C)cc(C(=O)OCC)nc12.CCOC(=O)C(=O)OCC>>CCCc1c2nc(C(=O)OCC)cc(C)c2cc2c(=O)cc(C(=O)OCC)oc12,,CCO,,Cl,[Na],val
US20080153837A1,ON=C1c2ccccc2-c2c1cccc2-c1nc2cccnc2[nH]1>>NC1c2ccccc2-c2c(-c3nc4cccnc4[nH]3)cccc21,[Ni],C1CCOC1,CCO,,,val
US05047411,Cc1ccn2cc(C=Cc3ccc([N+](=O)[O-])cc3)nc2c1>>Cc1ccn2cc(CCc3ccc(N)cc3)nc2c1,[Pd],C1CCOC1,,CO,[H][H],val
US20140031368A1,COC(=O)c1ccc(C(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1>>COC(=O)c1ccc(C(C(=O)O)C(=O)O)cc1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20040248903A1,COC(=O)c1occc1C.Cc1cccc(Cl)n1>>Cc1ccoc1C(=O)Cc1cccc(Cl)n1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US04665174,C=CCC1C(=O)C=CC1(C)O.CN>>C=CCC1=C(C)C(NC)CC1=O,,O,,,,val
US20140066369A1,O=C(n1ccnc1)n1ccnc1.OC1(C(F)(F)F)CCC1>>O=C(OC1(C(F)(F)F)CCC1)n1ccnc1,,C1CCOC1,,,,val
US05840732,CCCC=C1SC(=O)N(CCCOc2cccn3ccnc23)C1=O.Cl>>CCCC=C1SC(=O)N(CCCOc2cccn3ccnc23)C1=O.Cl,,CO,,,,val
US04348527,CC1CN(c2ccc(Cl)c(Cl)c2)N=C1NC=O>>CC1CN(c2ccc(Cl)cc2)N=C1NC=O,,O,,O=CO,,val
US20120184586A1,CC(C)I.COCCOCCOc1ccc(C2=N[C@@](C)(C(=O)O)CS2)c(O)c1>>COCCOCCOc1ccc(C2=N[C@@](C)(C(=O)OC(C)C)CS2)c(O)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20090143444A1,O=Cc1c[nH]c(Br)c1.OB(O)c1ccccc1Br>>O=Cc1c[nH]c(-c2ccccc2Br)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20100076080A1,CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1C#N.OO>>CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1C(N)=O,,CS(C)=O,O,[Na+].[OH-],,val
US20120208817A1,Br[Mg]c1ccccc1.CON(C)C(=O)Cc1ccc(Cl)c(Cl)c1>>O=C(Cc1ccc(Cl)c(Cl)c1)c1ccccc1,,C1CCOC1,,,,val
US20050215513A1,CCOP(=O)(CC=CCC(CC(C)=CCc1c(O)c2c(c(C)c1OC)COC2=O)C(=O)OC)OCC>>CCOP(=O)(O)CC=CCC(CC(C)=CCc1c(O)c2c(c(C)c1OC)COC2=O)C(=O)O,,CO,O,[Li+].[OH-],,val
US06063908,O=C(Cl)c1ccc(-c2ccc(C(=O)Cl)cc2)cc1.O=C1CCC(=O)N1O>>O=C(Cl)c1ccc(-c2ccc(C(=O)ON3C(=O)CCC3=O)cc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20110028487A1,CC1CC(C)CN(C(=O)CBr)C1.COC(=O)c1nc2[nH]ccn2c(=O)c1OC(C)=O>>COC(=O)c1nc2n(CC(=O)N3CC(C)CC(C)C3)ccn2c(=O)c1OC(C)=O,,CC#N,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20010027196A1,CS(=O)(=O)c1nc(N)nc(-c2ccco2)c1C#N.OCCCc1ccccc1>>N#Cc1c(OCCCc2ccccc2)nc(N)nc1-c1ccco1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20080200468A1,COC(=O)c1cscc1NC(=O)CCc1ccc(-c2ccccc2)nn1>>O=C(CCc1ccc(-c2ccccc2)nn1)Nc1cscc1C(=O)O,,C1CCOC1,CO,[Na+].[OH-],,val
US04214094,CCOC(=O)C(C)Oc1ccc(C=O)cc1.Nc1ccc(Cl)cc1>>CCOC(=O)C(C)Oc1ccc(C=Nc2ccc(Cl)cc2)cc1,,c1ccccc1,,,,val
US20040192767A1,Cc1oc(S(N)(=O)=O)cc1COc1ccc(-c2ccccc2)cc1.O=C(O)c1ccccc1>>Cc1oc(S(=O)(=O)NC(=O)c2ccccc2)cc1COc1ccc(-c2ccccc2)cc1,CN(C)c1ccncc1,C1CCOC1,CN(C)C=O,CCN=C=NCCCN(C)C,Cl,val
US20100087429A1,CC1(C)OB(C2=CCOCC2)OC1(C)C.NC1=N[C@@]2(CO1)c1cc(-c3cncnc3)ccc1Oc1ncc(Br)cc12>>NC1=N[C@@]2(CO1)c1cc(-c3cncnc3)ccc1Oc1ncc(C3=CCOCC3)cc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US04071519,CC(C)N=C=O.O=c1[nH]cc(F)c(=O)[nH]1>>CC(C)NC(=O)n1cc(F)c(=O)[nH]c1=O,,CS(C)=O,,O,,val
US20100056527A1,O=S(Cl)Cl.OCc1cc(Cl)cc2cc(-c3ccc(F)cc3F)oc12>>Fc1ccc(-c2cc3cc(Cl)cc(CCl)c3o2)c(F)c1,,ClCCl,,,,val
US05696231,CN(CC(=O)O)C(=O)OC(C)(C)C.ClCCl.OCC1c2ccccc2-c2ccccc21>>CNCC(=O)OCc1cccc2c1Cc1ccccc1-2.Cl,,CCOC(C)=O,,O=C(c1ncc[nH]1)c1ncc[nH]1,,val
US20040110832A1,COC(=O)Cc1ccc(O)cc1.O=[N+]([O-])c1ccc(F)cc1O>>O=C(O)Cc1ccc(Oc2ccc([N+](=O)[O-])c(O)c2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US08324226B2,CC(C)(C)OC(=O)N1CC[C@H](N)C1.Oc1ccccc1-c1cc(Cl)c2ccccc2n1>>CC(C)(C)OC(=O)N1CC[C@H](Nc2cc(-c3ccccc3O)nc3ccccc23)C1,,CS(C)=O,,O,,val
US20020120146A1,CCNN.O=C1CCCCC1C(=O)C1CCN(Cc2ccccc2)CC1>>CCn1nc2c(c1C1CCN(Cc3ccccc3)CC1)CCCC2,,O,,CC#N,,val
US20020035137A1,CC(=O)OC(C)=O.O=C(O)c1ccc2ccccc2c1.O=[N+]([O-])O>>CCOC(=O)c1ccc2cccc([N+](=O)[O-])c2c1,,O=S(=O)(O)O,,,,val
US20160096834A1,Cc1ccc(-n2ccn(-c3cccc(B4OC(C)(C)C(C)(C)O4)c3CO[Si](C)(C)C(C)(C)C)c2=O)cc1.Nc1nccc(Cl)c1[N+](=O)[O-]>>Cc1ccc(-n2ccn(-c3cccc(-c4ccnc(N)c4[N+](=O)[O-])c3CO[Si](C)(C)C(C)(C)C)c2=O)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,CC(=O)[O-].[K+],,val
US20100048564A1,COC(=O)c1cccc(OCc2nc3ccc(Oc4ccccc4)nc3n2C)c1.Cl.Cl>>Cl.Cl.Cn1c(COc2cccc(C(=O)O)c2)nc2ccc(Oc3ccccc3)nc21,,C1COCCO1,,Cl,[Na+].[OH-],val
US20090233929A1,O=C(CCl)c1cn(-c2cccc(Br)c2)cn1.Oc1cccnc1>>O=C(COc1cccnc1)c1cn(-c2cccc(Br)c2)cn1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150336893A1,CC(=O)c1cccc([N+](=O)[O-])c1.O=C(NC1CCCCC1)C1CCNCC1>>CC(c1cccc([N+](=O)[O-])c1)N1CCC(C(=O)NC2CCCCC2)CC1,,CO,,[BH4-].[Na+],,val
US20050026964A1,CCOC(=O)c1cnc(Cl)cc1Cl.Nc1ccc2ccccc2c1>>CCOC(=O)c1cnc(Cl)cc1Nc1ccc2ccccc2c1,,CCO,,Cl,,val
US20060094707A1,COC(=O)C[C@H](Cc1ccc2[nH]ncc2c1CO)C(=O)OC.O=S(Cl)Cl>>COC(=O)C[C@H](Cc1ccc2[nH]ncc2c1CCl)C(=O)OC.Cl,,ClCCl,,,,val
US20120065396A1,COC(=O)CCCCCN.COC(=O)c1cccc(Br)c1CBr>>COC(=O)CCCCCN1Cc2c(Br)cccc2C1=O,,C1CCOC1,,CCN(CC)CC,Cl,val
US20030087952A1,CN1C(=O)C[C@@H](c2ccccc2F)[C@H]1C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1>>CN1C(=O)C[C@@H](c2ccccc2F)[C@H]1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20090324963A1,CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].Cc1ccccc1.O=C(O)c1ccc(O)c(O)c1.[Ti+4]>>O=C(O)c1cccc([O-])c1[O-].O=C(O)c1cccc([O-])c1[O-].[Ti+4],,Cc1ccccc1,,,,val
US20090099184A1,CS(=O)(=O)c1ccc(CNC(=O)c2ccc(F)nc2)c(Cl)c1.Oc1ccc(F)cc1>>CS(=O)(=O)c1ccc(CNC(=O)c2ccc(Oc3ccc(F)cc3)nc2)c(Cl)c1,,CC(=O)N(C)C,,[H-].[Na+],,val
US04053476,CCOC(OCC)OCC.N#CC(C(N)=O)C1=CC(=O)CCC1>>N#Cc1c2c(c[nH]c1=O)C(=O)CCC2,,CCOC(C)=O,,CN(C)C=O,,val
US20060069077A1,C1COCCO1.COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OC1COCCN1C(=O)[O-]>>COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCC1CNCCO1,,C1COCCO1,CO,CCOCC,Cl,val
US20040029932A1,CCOC(=O)C(O)(CC(C)(C)c1cc(F)ccc1OC)C(F)(F)F.COCCl>>CCOC(=O)C(CC(C)(C)c1cc(F)ccc1OC)(OCOC)C(F)(F)F,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20140031575A1,C[Si](C)(C)C(CC(=O)OCc1ccccc1)C[N+](=O)[O-]>>C[Si](C)(C)C(CN)CC(=O)O,[Pd],CO,,O=C[O-].[NH4+],,val
US06936602B1,CCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3C(=O)OC(C)(C)C)cc1F>>CCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3)cc1F,,CCOC(C)=O,,Cl,[Na+].[OH-],val
US20110105461A1,CC(=O)Oc1cc(Br)cc(Cl)c1OCC1CO1>>OCC1COc2c(Cl)cc(Br)cc2O1,,C1COCCO1,,O,[K+].[OH-],val
US20130310411A1,COC(=O)c1cccc(S)c1.COc1ccc2c(Cl)c3c(Br)cccc3nc2c1>>COC(=O)c1cccc(Sc2c3ccc(OC)cc3nc3cccc(Br)c23)c1,,CN(C)C=O,,[H-].[Na+],,val
US20090281141A1,COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCN(C)C(=O)N4C3)nccc2c1Br.NS(=O)(=O)C1CC1>>COc1ccc2c(OC3CC4C(=O)NC5(C(=O)NS(=O)(=O)C6CC6)CC5C=CCCCCN(C)C(=O)N4C3)nccc2c1Br,,C1CCOC1,,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20040138230A1,CC1(C)CC(=O)Nc2ccc(CCCCl)cc21.c1ccc2c(N3CCNCC3)nsc2c1>>CC1(C)CC(=O)Nc2ccc(CCCN3CCN(c4nsc5ccccc45)CC3)cc21,,CCOC(C)=O,O,CC#N,O=C([O-])[O-].[Na+].[Na+],val
US20090036478A1,CC(C)(C)C(=O)OC1CC(O[Si](C)(C)C(C)(C)C)C1>>CC(C)(C)[Si](C)(C)OC1CC(O)C1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20140194536A1,CC(=CCCCO)CCCC(C)CCCC(C)C.CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(=O)OC[C@H]1OC(OCCCC=C(C)CCCC(C)CCCC(C)C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,CC#N,CCOC(C)=O,CCN(CC)CC,,val
US20090143371A1,Cc1nc(OCc2c(-c3ccccc3)noc2C)c(Br)cc1C(=O)NC1CCOCC1>>Cc1nc(OCc2c(-c3ccccc3)noc2C)ccc1C(=O)NC1CCOCC1,[Pd],C1CCOC1,CO,O=C[O-].[NH4+],,val
US20070032478A1,Cc1cc(C(=O)Nc2ccc(C(=O)c3ccc4c(c3)NC(=O)C4=CO)cc2)n(C(C)(C)C)n1.Nc1cccc(O)c1>>Cc1cc(C(=O)Nc2ccc(C(=O)c3ccc4c(c3)NC(=O)C4=CNc3cccc(O)c3)cc2)n(C(C)(C)C)n1,,C1CCOC1,,,,val
US04002640,CC(=O)Nc1ccc(O)cc1[N+](=O)[O-].CSCCl>>CSCOc1ccc(NC(C)=O)c([N+](=O)[O-])c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150274663A1,CCCCCCCCO.Oc1ccc(Br)cc1>>CCCCCCCCOc1ccc(Br)cc1,,Cc1ccccc1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120264749A1,CC(=O)CNC(=O)C1CN(Cc2ccccc2)CC2(CCN(C(=O)c3ccc(OC(C)C)c(C)c3)CC2)O1>>Cc1cc(C=O)ccc1OC(C)C,,C1CCOC1,,,,val
US20090076282A1,CCOC(O)C(F)(F)F.Cc1cc(F)c(NN)cc1SCC(F)(F)F>>Cc1cc(F)c(NN=CC(F)(F)F)cc1SCC(F)(F)F,,CCO,,CS(=O)(=O)O,,val
US03984412,CCCCNc1c(C(=O)OCC)c(C)nc(Cl)c1[N+](=O)[O-].N>>CCCCNc1c(C(=O)OCC)c(C)nc(N)c1[N+](=O)[O-],,CO,,,,val
US20050065150A1,COCOc1c(C)c(C)c2c(c1C)CCC(C)(C=O)O2.ClC(Cl)(Cl)Cl>>COCOc1c(C)c(C)c2c(c1C)CCC(C)(C=C(Cl)Cl)O2,[Zn],ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04663453,Cc1ccc(N2CCc3cc(Br)ccc32)c([N+](=O)[O-])c1.ClCCl>>Cc1ccc(N2CCc3cc(Br)ccc32)c(N)c1.Cl,[Pt],CCO,,,,val
US20020052355A1,Nc1c(Cl)cccc1C(=O)O.O=C=NCCCCl>>O=c1c2cccc(Cl)c2nc2n1CCCO2,,O,,,,val
US20150376136A1,COc1ccc(CCl)cc1.O=C1NC(=O)C(Cc2ccccc2Cl)N1>>COc1ccc(CN2C(=O)NC(Cc3ccccc3Cl)C2=O)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04271160,CCBr.CN1CC(C(Oc2ccccc2O)c2ccccc2)OCC1=O>>CCOc1ccccc1OC(c1ccccc1)C1CN(C)C(=O)CO1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05854272,CN1C[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1COCc1ccccc1.Cl>>CN1C[C@@H](O)[C@H](O)[C@H]1CO.Cl,[Pd],CCO,,,,val
US04440766,CCC(C)(C)OC(=O)Nc1nc(C(=O)C(=O)O)cs1.NC1C(=O)N2C(C(=O)O)=C(CSc3nncs3)CS[C@H]12>>CCC(C)(C)OC(=O)Nc1nc(C(=O)C(=O)NC2C(=O)N3C(C(=O)O)=C(CSc4nncs4)CS[C@H]23)cs1,,CCOC(C)=O,CN(C)C=O,O=P(Cl)(Cl)Cl,O=C([O-])O.[Na+],val
US20070249587A1,CC(C)(C)OC(=O)N1CCC(CO)(CO)CC1.Cl>>Cl.OCC1(CO)CCNCC1,,CO,,C1COCCO1,,val
US04607031,Cc1ccc(-c2nc3cc(F)ccc3s2)cc1.O=C1CCC(=O)N1Br>>Fc1ccc2sc(-c3ccc(CBr)cc3)nc2c1,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US06476053B1,CC1=CC(=O)OC1=O.CCCCCCCCN>>CCCCCCCCN1C(=O)C=C(C)C1=O,,c1ccncc1,,,,val
US20040225125A1,COc1ccc(CN)cc1.Clc1nc(Cl)nc(Cl)n1>>COc1ccc(CNc2nc(Cl)nc(Cl)n2)cc1,,C1CCOC1,,,,val
US20130030019A1,O=C(CN1CC[C@@H](c2cc(-c3ccc(Cl)cc3)n[nH]2)[C@H](c2ccc(F)cc2)C1)c1ccccc1>>OC(CN1CC[C@@H](c2cc(-c3ccc(Cl)cc3)n[nH]2)[C@H](c2ccc(F)cc2)C1)c1ccccc1,,CCO,,[BH4-].[Na+],,val
US04992432,COc1ccc([C@H]2SC=C(c3ccccc3)N(CCN(C)C)C(=O)[C@H]2OC(C)=O)cc1>>COc1ccc([C@H]2SC=C(c3ccccc3)N(CCN(C)C)C(=O)[C@H]2OC(C)=O)cc1,,O,,Cl,[NH4+].[OH-],val
US20050014812A1,COc1cc(-c2ccccc2)ccc1CO.CS(=O)(=O)Cl>>COc1cc(-c2ccccc2)ccc1CCl,,Cc1ccccc1,,CCN(CC)CC,,val
US20110086854A1,CC(C)(C)CC1NCC(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.CCOC(=O)c1ccc(N=C=O)cc1>>CCOC(=O)c1ccc(NC(=O)N2C[C@H](c3cccc(Cl)c3F)[C@@](C#N)(c3ccc(Cl)cc3F)[C@@H]2CC(C)(C)C)cc1,,ClCCl,,CCN(CC)CC,O,val
US20080045554A1,CCCCCN1c2nc(C(F)(F)F)[nH]c2C(=O)NC1SC.NN>>CCCCCn1/c(=N/N)[nH]c(=O)c2[nH]c(C(F)(F)F)nc21,,O,,,,val
US20150295179A1,CCCCCCCCCCCCC(CBr)CCCCCCCCCC.O=C1Nc2cc(Br)ccc2C1=O>>CCCCCCCCCCCCC(CCCCCCCCCC)CN1C(=O)C(=O)c2ccc(Br)cc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070167497A1,COC(=O)c1ccccc1SCc1cccnc1>>O=C(O)c1ccccc1SCc1cccnc1,,CO,O,[Li+].[OH-],,val
US20070185079A1,C1=CCC=C1.C=CC(=O)O[C@@H]1CC(=O)N(C)C1=O>>CN1C(=O)C[C@@H](OC(=O)[C@H]2C[C@H]3C=C[C@@H]2C3)C1=O,Cl[Ti](Cl)(Cl)Cl,CCCCCC,,ClCCl,,val
US04672064,COc1ccc2c(c1)SC(CCCCl)C(=O)CO2>>COc1ccc2c(c1)SC(CCCCl)C(O)CO2,,C1CCOC1,CO,[BH4-].[Na+],,val
US06156758,COc1ccc2[nH]c(N3CCC(Nc4ccc(C(=O)OC(C)(C)C)cc4)CC3)nc2c1>>COc1ccc2[nH]c(N3CCC(Nc4ccc(C(=O)O)cc4)CC3)nc2c1,,O=C(O)C(F)(F)F,,,,val
US20020037888A1,C=CCc1c(Br)cncc1Br.N#Cc1ccc(C=O)cc1F>>C=CCc1c(Br)cncc1C(O)c1ccc(C#N)c(F)c1,,C1CCOC1,,[Li]CCCC,,val
US04409017,CCOC(=O)C(C)(C)Br.CN(c1ccc(O)cc1)c1cc2ccc(Cl)cc2c(Cl)n1>>CCOC(=O)C(C)(C)Oc1ccc(N(C)c2cc3ccc(Cl)cc3c(Cl)n2)cc1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20120004228A1,COC(=O)c1cc(I)cc(C(=O)c2ccc(N(C)c3ccc(Cl)cc3)cn2)c1.C[Sn](C)(C)[Sn](C)(C)C>>COC(=O)c1cc(C(=O)c2ccc(N(C)c3ccc(Cl)cc3)cn2)cc([Sn](C)(C)C)c1,,Cc1ccccc1,,,,val
US20110076276A1,COc1ccc(Cn2c(=O)c(C(C)C)c(C(=O)c3cc(C)cc(C#N)c3)n(CCOC(C)=O)c2=O)cc1>>COc1ccc(Cn2c(=O)c(C(C)C)c(C(=O)c3cc(C)cc(C#N)c3)n(CCO)c2=O)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20100249099A1,C1CCNC1.C=CS(=O)(=O)N1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4c(OC)cccc43)n2)CC1>>COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(S(=O)(=O)CCN3CCCC3)CC2)n1,,C1COCCO1,,,,val
US20100305104A1,CNC.COc1ccc(F)cc1-c1noc(-c2ccc(-c3ccccc3C)c(CO)c2)n1>>COc1ccc(F)cc1-c1noc(-c2ccc(-c3ccccc3C)c(CN(C)C)c2)n1,,ClCCl,O,CCN(C(C)C)C(C)C,CS(=O)(=O)Cl,val
US20150108402A1,CCOc1ccc(-c2ccc(CCCO)cc2)c(F)c1F.CS(=O)(=O)Cl>>CCOc1ccc(-c2ccc(CCCOS(C)(=O)=O)cc2)c(F)c1F,,ClCCl,,CCN(CC)CC,,val
US20120142717A1,CCc1c[nH]c(OCCc2cc(F)c(Oc3cnc(C(F)(F)F)nc3)c(F)c2)nc1=O.CI>>CCc1cn(C)c(OCCc2cc(F)c(Oc3cnc(C(F)(F)F)nc3)c(F)c2)nc1=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060166955A1,CC(=O)OC(C)=O.C[C@@H]1CC[C@@]2(OC1)O[C@H]1C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4C[C@@H](O)[C@]3(C)[C@H]1[C@@H]2C>>CC(=O)C1=CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3C[C@@H](O)[C@]12C,,CC(=O)OC(C)=O,,CC(=O)O,,val
US20130115190A1,COc1ccc2c(=O)[nH]ccc2c1.O=C1CCC(=O)N1Br>>COc1ccc2c(=O)[nH]cc(Br)c2c1,,CC#N,,,,val
US20020128321A1,Nc1ccc([N+](=O)[O-])cc1N.O=S(=O)(Cl)c1ccccc1>>Nc1ccc([N+](=O)[O-])cc1NS(=O)(=O)c1ccccc1,,CN(C)C=O,,CCN(CC)CC,,val
US20120184531A1,[N-]=[N+]=NCCc1cc2cc(Br)cc(Cl)c2o1>>NCCc1cc2cc(Br)cc(Cl)c2o1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090163488A1,Cn1nc(C(=O)O)c2ccccc21.Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)c1>>Cn1nc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)c2ccccc21,CN(C)C=O,CC(=O)N(C)C,,C1CCOC1,O=C(Cl)C(=O)Cl,val
US07141598B2,Brc1cccc(Br)c1.OB(O)c1ccc(F)cc1>>Fc1ccc(-c2cccc(Br)c2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20080090856A1,CC(C)(C)OC(=O)N1CCc2cc(-n3nc(C(C)(C)C)cc3N)ccc2C1.O=C(Cl)OCC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1CCc2cc(-n3nc(C(C)(C)C)cc3C(=O)OCC(Cl)(Cl)Cl)ccc2C1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US06184225B2,BrCCBr.COc1cc2c(Oc3ccccc3)ncnc2cc1O>>COc1cc2c(Oc3ccccc3)ncnc2cc1OCCBr,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020119983A1,CC(CC=O)c1cc(-c2cccs2)no1.c1ccc(CN2CCNCC2)cc1>>c1ccc(CN2CCN(CCCCc3cc(-c4cccs4)no3)CC2)cc1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100311750A1,CC[C@@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@H](Cc2ccccc2)N1C(=O)OC(C)(C)C>>CC[C@@H]1C[C@H](O)[C@H](Cc2ccccc2)N1C(=O)OC(C)(C)C,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20060194788A1,CCOC(=O)C1CCCc2sc(NC(=N)N)nc21>>N=C(N)Nc1nc2c(s1)CCCC2C(=O)O,,CO,O,Cl,[Na+].[OH-],val
US04267180,CC(=O)OC(C)=O.CC(C)(N)C(=O)O>>CC(=O)NC(C)(C)C(=O)O,,O,,c1ccncc1,,val
US06150373,CSc1ncc(CNc2c(C)cccc2Cl)c(Nc2cccc(CCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)c2)n1.O=C(Cl)Cl>>CSc1ncc2c(n1)N(c1cccc(CCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)c1)C(=O)N(c1c(C)cccc1Cl)C2,,C1CCOC1,,CCN(CC)CC,,val
US20090054431A1,COc1cc(C=O)ccc1F.Nc1ccc(O)cc1[N+](=O)[O-]>>COc1cc(C=O)ccc1Oc1ccc(N)c([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150353499A1,COc1ccc2cc(F)ccc2c1CN1C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)CCc2ccccc21.Cl>>CN[C@@H](C)C(=O)N[C@H]1CCc2ccccc2N(Cc2c(OC)ccc3cc(F)ccc23)C1=O.Cl,,CO,,CCOCC,,val
US20100113511A1,CCCCc1ccc(CCCCBr)cc1.Cc1cccnc1>>CCCCc1ccc(CCCC[n+]2cccc(C)c2)cc1.[Br-],,CC#N,,,,val
US20020037878A1,CC(=O)OC(C)N1C(=O)/C(=C\c2[nH]c(C)cc2C)c2ccccc21>>Cc1cc(C)c(/C=C2\C(=O)N(C(C)O)c3ccccc32)[nH]1,,O=CO,,CC#N,,val
US20160002255A1,COC(=O)[C@@H](C)[C@H](c1ccc(I)c(O[C@@H](CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c2ccc(-c3cc(OC)ccc3F)nc2C(F)(F)F)c1)C1CC1>>COC(=O)[C@@H](C)[C@H](c1ccc(I)c(O[C@@H](CO)c2ccc(-c3cc(OC)ccc3F)nc2C(F)(F)F)c1)C1CC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04070366,CC(C)C=O.CCOC(=O)c1cc(C)c(C)[nH]1>>CCOC(=O)c1[nH]c(C)c(C)c1CC(C)C,,O,,,,val
US20090023763A1,CS(=O)(=O)c1nccc(-c2cc3cn[nH]c3nc2-c2ccco2)n1.NC1CC1>>c1coc(-c2nc3[nH]ncc3cc2-c2ccnc(NC3CC3)n2)c1,,CC#N,,CCN(CC)CC,,val
US05420126,CC1(C)Oc2ccc([N+](=O)[O-])cc2NC1=O.CCOC(=O)CBr>>CCOC(=O)CN1C(=O)C(C)(C)Oc2ccc([N+](=O)[O-])cc21,,CN(C)C=O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20090163508A1,CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccc(F)cc3F)ncn2)CC1>>Fc1ccc(-c2cc(N3CCNCC3)ncn2)c(F)c1,,CCOC(C)=O,,Cl,,val
US05576335,CN(C)c1ccc(NC(=O)c2ccccc2N)cc1>>CN(C)c1ccc(NCc2ccccc2N)cc1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20090137548A1,COC(=O)c1ccc(-c2ccc(Cl)c(-c3ccc(C(F)(F)F)cc3CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)c2)c(C)c1>>Cc1cc(C(=O)O)ccc1-c1ccc(Cl)c(-c2ccc(C(F)(F)F)cc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)c1,,CCO,,[K+].[OH-],,val
US20060173004A1,COC(=O)/C=C/c1ccc(Cl)cc1NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)O,,CO,,O,[Na+].[OH-],val
US20060025423A1,COc1nc(Br)c(C)nc1N>>COc1ncc(C)nc1N,[Pd],CO,,O=C[O-].[NH4+],,val
US05849757,CCOC(=O)C1(NC(=O)OC(C)(C)C)CCC1>>CC(C)(C)OC(=O)NC1(C(=O)O)CCC1,,CO,,[Na+].[OH-],,val
US20100120859A1,COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@@H]2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)cc(OC[C@@H]2C[C@H]2C(=O)O)c1.O=[N+]([O-])OC[C@@H](CCCCO)O[N+](=O)[O-]>>COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@@H]2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)cc(OC[C@@H]2C[C@H]2C(=O)OCCCC[C@H](CO[N+](=O)[O-])O[N+](=O)[O-])c1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20060148858A1,CCOC(=O)C(C=O)CC.CCOC(=O)CNN>>CCOC(=O)Cn1ncc(CC)c1O,,CCO,,Cl,[Na+].[OH-],val
US20110112104A1,CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2cc3c(cn2)N2CCN(Cc4ccccc4-c4ccc(Cl)cc4)CC2C3)cc1[N+](=O)[O-].Cl.ClCCl>>CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2cc3c(cn2)N2CCN(Cc4ccccc4-c4ccc(Cl)cc4)CC2C3)cc1[N+](=O)[O-].Cl.Cl.Cl,,ClCCl,,,,val
US20070066607A1,NC1(CO)Cc2ccccc2C1.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1C1(CO)Cc2ccccc2C1,,O,,,,val
US05399568,CC(=O)OC(c1cccnc1)C1CCN(CC23CC(c4ccccc42)c2ccccc23)CC1>>c1cncc(CC2CCN(CC34CC(c5ccccc53)c3ccccc34)CC2)c1,[Pd],CO,,O=C[O-].[NH4+],,val
US04092150,CC(C)(C#N)Nc1nc(Cl)c(C#N)c(Cl)n1.CCN>>CCNc1nc(NC(C)(C)C#N)nc(Cl)c1C#N,,CC(C)=O,,O,,val
US20040006099A1,CCOC(=O)C1(CC(=O)O)CCN(C(=O)OC(C)(C)C)CC1.OCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCOC(=O)C1(CNC(=O)OCc2ccccc2)CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,O,CCN(CC)CC,,val
US20110130371A1,C[C@]12C[C@H](F)[C@@]3(Br)[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1[C@@H]1C[C@@H]1C2=O>>C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](F)C[C@]2(C)C(=O)[C@H]3C[C@H]3[C@@H]12,,c1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US20120035122A1,CC(=O)OC(C)=O.FC1(c2ccc(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)cc2)CNC1>>CC(=O)N1CC(F)(c2ccc(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)cc2)C1,,ClCCl,O,CCN(CC)CC,,val
US20050065151A1,O=[N+]([O-])c1ccnc(C2=CCOCC2)c1>>Nc1ccnc(C2CCOCC2)c1,[Pd],C1CCOC1,CC(=O)O,,,val
US05356558,CCCCCc1ccc(C#CC(C)(C)O)cc1>>C#Cc1ccc(CCCCC)cc1,,Cc1ccccc1,,O,[H-].[Na+],val
US20080064715A1,CC(=O)c1cc2ccncc2[nH]1.Cl.Cl.N=C(N)NN>>CC(=NNC(=N)N)c1cc2ccncc2[nH]1.Cl.Cl,,CCO,Cl,,,val
US20090286778A1,O=C(Nc1ccc2cc1CCc1cccc(c1)Nc1ncc(Cl)c(n1)N2)C1CCNCC1.O=C(O)C(F)(F)F.O=S(=O)(Cl)c1ccccc1>>O=C(Nc1ccc2cc1CCc1cccc(c1)Nc1ncc(Cl)c(n1)N2)C1CCN(S(=O)(=O)c2ccccc2)CC1.O=C(O)C(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20110105461A1,C1COCCN1.Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1>>CS(=O)(=O)c1cc(F)c2c(c1)O[C@@H](CN1CCOCC1)CO2,,CC#N,,,,val
US20120202776A1,CP(C)(=O)c1ccc(N)cc1.Cc1nc(Cl)cc(Cl)n1>>Cc1nc(Cl)cc(Nc2ccc(P(C)(C)=O)cc2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05952362,CS(=O)(=O)n1ccc2ccc([N+](=O)[O-])cc21>>CS(=O)(=O)n1ccc2ccc(N)cc21,O=[Pt],CO,,,,val
US20130210796A1,CC(C)(C)OC(=O)N1CCN(Cc2nnnn2-c2cccc(C(F)(F)F)c2)CC1(C)C>>CC1(C)CN(Cc2nnnn2-c2cccc(C(F)(F)F)c2)CCN1,,CO,,C1COCCO1,Cl,val
US20130116246A1,CN1CCc2nc(Nc3cc(-c4ccnc(-n5ncc6cc(C(C)(C)C)cc(F)c6c5=O)c4C=O)cn(C)c3=O)sc2C1>>CN1CCc2nc(Nc3cc(-c4ccnc(-n5ncc6cc(C(C)(C)C)cc(F)c6c5=O)c4CO)cn(C)c3=O)sc2C1,,CO,,[BH4-].[Na+],,val
US20110227049A1,Brc1ccnc(Br)c1.OB(O)c1ccccc1>>Brc1ccnc(-c2ccccc2)c1,,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20090186296A1,O=C(Cl)C12CC3CC(CC(C3)C1)C2.OCC(F)(F)Br>>O=C(OCC(F)(F)Br)C12CC3CC(CC(C3)C1)C2,,C1CCOC1,,CCN(CC)CC,,val
US20030073712A1,COCOc1ccc(C=Cc2ccc(C3=NN(c4ccccc4)C(=O)C3)cc2)cc1OCOC>>O=C1CC(c2ccc(C=Cc3ccc(O)c(O)c3)cc2)=NN1c1ccccc1,,CO,,Cl,,val
US05231223,Nc1ccc(S(=O)(=O)O)cc1.Nc1ccccc1S(=O)(=O)O>>C=Cc1ccc(S(=O)(=O)O)cc1,,CC(C)O,,CO,,val
US20150197511A1,Cc1ccccc1S(=O)(=O)Cl.OCCF>>Cc1ccc(S(=O)(=O)OCCF)cc1,,ClCCl,,CCN(CC)CC,,val
US20030191115A1,CC(C)N=C=NC(C)C.CN(C)C=O.N#Cc1cc(-n2nc(C(N)=O)cc2C(=O)O)ccc1F.c1ccncc1>>N#Cc1cc(-n2nc(C(N)=O)cc2C(=O)N2CCc3ccc(N4CCCCCC4=O)cc32)ccc1F,,CN(C)C=O,,Cl,,val
US04990517,CCOC(=O)c1cn(C2CC2)c2cc(Cl)c(F)c(Cl)c2c1=O>>O=C(O)c1cn(C2CC2)c2cc(Cl)c(F)c(Cl)c2c1=O,,CC(=O)O,,O,O=S(=O)(O)O,val
US20130203731A1,C1COCCN1.Cc1cc2nc(NC(=O)c3ccc(C(F)(F)F)nc3)cc(Cl)n2n1>>Cc1cc2nc(NC(=O)c3ccc(C(F)(F)F)nc3)cc(N3CCOCC3)n2n1,,CN(C)C=O,,,,val
US20100204196A1,CN.COc1cc2c(cc1Nc1nc3c(ccn3S(=O)(=O)c3ccc(C)cc3)c3nc4ccc(F)c(F)c4c(=O)n13)N(C(=O)CN(C)C)CCC2>>CNC(=O)c1c(Nc2nc(Nc3cc4c(cc3OC)CCCN4C(=O)CN(C)C)nc3c2ccn3S(=O)(=O)c2ccc(C)cc2)ccc(F)c1F,,C1CCOC1,CCOC(C)=O,,,val
US20130065880A1,Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)NCCCNC(=O)OC(C)(C)C)c[nH]4)c3)cc2F)c1>>Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)NCCCN)c[nH]4)c3)cc2F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150133457A1,COCCOc1ccc(Nc2nc(Oc3cccc([N+](=O)[O-])c3)c3cc[nH]c3n2)cc1F>>COCCOc1ccc(Nc2nc(Oc3cccc(N)c3)c3cc[nH]c3n2)cc1F,O=[Pt]=O,C1CCOC1,,[H][H],,val
US20160052884A1,CCOC(=O)c1ccc(NC(=O)C(CC(F)(F)F)n2cc(OC)c(-c3cc(Cl)ccc3C#N)cc2=O)cc1>>COc1cn(C(CC(F)(F)F)C(=O)Nc2ccc(C(=O)O)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N,,CO,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120232051A1,CNc1cnccc1-c1ccccc1C.O=C(O)c1cc(Cl)cc(OC(F)(F)F)c1>>Cc1ccccc1-c1ccncc1N(C)C(=O)c1cc(Cl)cc(OC(F)(F)F)c1,,CCCCCCC,CCOC(C)=O,,,val
US20050288524A1,C=CCCC(=O)c1ccccc1.Cl[Mg]C1C=CC=C1>>C=CCCC(=C1C=CC=C1)c1ccccc1,,C1CCOC1,O,Cl,[Cl-].[NH4+],val
US20130065902A1,NNc1ccc(F)cc1.O=C1CCC(NC(=O)OCc2ccccc2)CC1>>O=C(NC1CCc2[nH]c3ccc(F)cc3c2C1)OCc1ccccc1,,CC(=O)O,CCOC(C)=O,Cl,,val
US20090298744A1,CCCn1c(=O)c2c(nc(-c3ccc(O)cc3)n2COCC[Si](C)(C)C)n(CCC)c1=O.FC(F)(F)Oc1ccc(C#CCBr)cc1>>CCCn1c(=O)c2c(nc(-c3ccc(OCC#Cc4ccc(OC(F)(F)F)cc4)cc3)n2COCC[Si](C)(C)C)n(CCC)c1=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050131042A1,CCOC(CN)OCC.Cc1nc(CCl)cs1>>CCOC(CNCc1csc(C)n1)OCC,,C1CCOC1,,,,val
US04237056,CC(O)C(C)O.COC(CN(C)C(=O)CCl)OC>>CC1OC(N(C)C(=O)CCl)OC1C,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100121052A1,COc1cc2nc(Cl)ncc2cc1Br.Nc1cccc(CN2CCOCC2)c1>>COc1cc2nc(Nc3cccc(CN4CCOCC4)c3)ncc2cc1Br,,CC(C)O,CCOC(C)=O,C1COCCO1,Cl,val
US04992435,CC1(C)CC(=O)c2sccc2O1>>CC1(C)CC(O)c2sccc2O1,,CCO,,O,[BH4-].[Na+],val
US20070249722A1,COC(=O)[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)C(CC(F)(F)F)CC(F)(F)F>>O=S(=O)(N[C@H](CO)C(CC(F)(F)F)CC(F)(F)F)c1ccc(Cl)cc1,,C1CCOC1,,[BH4-].[Li+],,val
US20020099215A1,CC(C)(C)OC(=O)N1CCC(C(=O)N[C@@H](Cc2cccnc2)C(=O)NC(CCCc2ccccc2)CCCc2ccccc2)CC1>>O=C(N[C@@H](Cc1cccnc1)C(=O)NC(CCCc1ccccc1)CCCc1ccccc1)C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090074738A1,COC(=O)c1ccc(CBr)cc1.Cc1cccc2c([C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc4ccccc4)[C@H](OCc4ccccc4)[C@H]3OCc3ccccc3)c[nH]c12>>COC(=O)c1ccc(Cn2cc([C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc4ccccc4)[C@H](OCc4ccccc4)[C@H]3OCc3ccccc3)c3cccc(C)c32)cc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20020032208A1,COc1cc2c(Cl)ncnc2cc1OCc1ccncc1.Cc1cc(F)c(N)cc1O.Cl>>COc1cc2c(Nc3cc(O)c(C)cc3F)ncnc2cc1OCc1ccncc1.Cl,,CC(C)O,,,,val
US05852038,CCN(CC)C(=O)C1CN2CCC1C(=O)C2.O=Cc1ccccc1>>CCN(CC)C(=O)C1CN2CCC1C(=O)C2=Cc1ccccc1,,CCO,,[Na+].[OH-],,val
US06201006B1,CCOC(=O)CN(CC(=O)N1CCC[C@H]1CCc1cc2ccc(C(=N)N)cc2n1CC)C1CC1>>CCn1c(CC[C@@H]2CCCN2C(=O)CN(CC(=O)O)C2CC2)cc2ccc(C(=N)N)cc21,,CCO,,[Na+].[OH-],,val
US20130237525A1,CC(C)(C)S(N)=O.CCOC(=O)C=O>>CCOC(=O)C=NS(=O)C(C)(C)C,,ClCCl,,,,val
US20010053779A1,CC(C)(C)OC(=O)CCCCl.CCOC(=O)c1ccccc1O>>CCOC(=O)c1ccccc1OCCCC(=O)OC(C)(C)C,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070244095A1,COC(=O)c1cc(CN2CCC[C@H](N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnn(C)n3)c3cc(C)c(C(F)(F)F)cc32)ccc1O>>Cc1cc2c(cc1C(F)(F)F)N(Cc1ccc(O)c(C(=O)O)c1)CCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1,,CO,,Cl,[Na+].[OH-],val
US20120238574A1,CC(C)(C)OC(=O)N1CCC(n2ncc3cc([N+](=O)[O-])ccc32)CC1>>CC(C)(C)OC(=O)N1CCC(n2ncc3cc(N)ccc32)CC1,[Pd],CCO,,[H][H],,val
US20130045964A1,Cc1nnc(CN)[nH]1.O=C(O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1>>Cc1nnc(CNC(=O)C(O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)[nH]1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030078271A1,Nc1cccc(C(F)(F)F)c1.O=C1Nc2ccc(Br)cc2C1=O>>O=C1Nc2ccc(Br)cc2/C1=N/c1cccc(C(F)(F)F)c1,,CO,,CC(=O)O,,val
US20140221330A1,O=C(C=P(c1ccccc1)(c1ccccc1)c1ccccc1)OCc1ccccc1.O=C1CCC2(CC1)OCCO2>>O=C(C=C1CCC2(CC1)OCCO2)OCc1ccccc1,,Cc1ccccc1,,,,val
US20050187266A1,Brc1cccc(Br)n1.Cc1oc(-c2ccccc2)nc1CCO>>Cc1oc(-c2ccccc2)nc1CCOc1cccc(Br)n1,,C1COCCO1,,[H-].[Na+],,val
US20110183919A1,CC(C)C(NC(=O)OC(C)(C)C)C(=O)O.CC(N)C(=O)NC(CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F>>CC(NC(=O)C(NC(=O)OC(C)(C)C)C(C)C)C(=O)NC(CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F,,ClCCl,,,,val
US20140243322A1,Cc1ccc(-c2c(C)noc2C)cc1.O=S(=O)(O)Cl>>Cc1ccc(-c2c(C)noc2C)cc1S(=O)(=O)Cl,,ClCCl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20080230743A1,CC(CN(CCC#N)CCC#N)N(CCC#N)CCC#N>>CC(CN(CCCN)CCCN)N(CCCN)CCCN,,C1COCCO1,,[H][H],,val
US20070185153A1,CC(C)(C)OC(=O)NC1CCNCC1.Cc1ccc(S(=O)(=O)OCC2(O)Cn3c(=O)c(F)cc4ncc(F)c2c43)cc1>>CC(C)(C)OC(=O)NC1CCN(CC2(O)Cn3c(=O)c(F)cc4ncc(F)c2c43)CC1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20040043960A1,BrC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.CC1(C)O[C@@H]2[C@@H](O1)[C@H](n1cnc3c(Cl)ncnc31)O[C@@H]2C=O>>C#C[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20100003710A1,O=C(CCCCCCCCCCS)NC[c-]1cccc1.[Fe+2].c1cc[cH-]c1.c1ccc(SSc2ccccn2)nc1>>O=C(CCCCCCCCCCSSc1ccccn1)NC[c-]1cccc1.[Fe+2].c1cc[cH-]c1,,CO,ClCCl,CCN(CC)CC,,val
US20080176900A1,CC1(N)CCC(=O)NC1=O.O=C1OC(=O)c2cscc21>>CC1(N2C(=O)c3cscc3C2=O)CCC(=O)NC1=O,CN(C)c1ccncc1,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20020037888A1,CC(=O)OC(c1ccc(C#N)c(F)c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.COS(=O)(=O)OC>>CC(=O)OC(c1ccc(C#N)c(F)c1)c1cncn1C,,CCOC(C)=O,,,,val
US20150315188A1,CN1CCc2[nH]c3c(Cl)ccc(Cl)c3c2C1.c1cncc(C2CO2)c1>>CN1CCc2c(c3c(Cl)ccc(Cl)c3n2CC(O)c2cccnc2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20090306066A1,C[C@H]1CNCCN1C(=O)OCc1ccccc1.O=CCOCc1ccccc1>>C[C@H]1CN(CCOCc2ccccc2)CCN1C(=O)OCc1ccccc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100240658A1,COCc1cc(-c2nc(-c3ccc(C(=O)NCCC(=O)OC)c(F)c3)no2)ccc1-c1ccccc1C>>COCc1cc(-c2nc(-c3ccc(C(=O)NCCC(=O)O)c(F)c3)no2)ccc1-c1ccccc1C,,CO,O,CCOC(C)=O,[Na+].[OH-],val
US20110301181A1,CCOC(=O)c1sc(C(F)(F)C(F)(F)F)nc1C(F)(F)F>>O=C(O)c1sc(C(F)(F)C(F)(F)F)nc1C(F)(F)F,,CO,O,Cl,[Na+].[OH-],val
US20120190548A1,C=C[Sn](CCCC)(CCCC)CCCC.COC(=O)c1nc(Cl)cc(Cl)c1I>>C=Cc1c(Cl)cc(Cl)nc1C(=O)OC,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,ClCCCl,,,,val
US06300363B1,CC(=O)OCc1ccoc1C(=O)CBr.CCOC(=O)Nc1cc(Cl)ccc1C#N>>CCOC(=O)n1c(C(=O)c2occc2CO)c(N)c2ccc(Cl)cc21,,CN(C)C=O,,O,[H-].[Na+],val
US07078414B2,COC(=O)c1c[nH]cc1C.Clc1nccc2ccccc12>>COC(=O)c1cn(-c2nccc3ccccc23)cc1C,,CN(C)C=O,,O,[H-].[Na+],val
US06034239,N#C/C=C1\CCc2cc(Br)c3c(c21)CCO3>>Br.NCCC1CCc2ccc3c(c21)CCO3,[Ni],CCO,,N,[H][H],val
US20120046307A1,ClCCl.Nc1ccc(Cl)cc1N.O=C1C=C(c2ccc(Cl)cc2)C(=O)O1>>Cl.O=C(O)C(Cc1nc2ccc(Cl)cc2[nH]1)c1ccc(Cl)cc1,,ClCCl,,,,val
US04654343,CC(=O)Nc1cccc(-c2ccc3nncn3n2)c1.CCI>>CCN(C(C)=O)c1cccc(-c2ccc3nncn3n2)c1,,CN(C)C=O,,[H-].[Na+],,val
US06096811,CCC(C)C(N)C(=O)O.O=C1OC(=O)C2C3C=CC(C3)C12>>CCC(C)C(C(=O)O)N1C(=O)C2C3C=CC(C3)C2C1=O,,Cc1ccccc1,,CCN(CC)CC,,val
US20150011543A1,CCOC(=O)c1c(N)[nH]c2cc(C(=O)OC)ccc12.NC=O>>COC(=O)c1ccc2c(c1)[nH]c1ncnc(O)c12,,O,,O=C[O-].[NH4+],,val
US20050130941A1,C=C[C@@H](N)Cc1ccc(F)cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>C=C[C@H](Cc1ccc(F)cc1)NC(=O)C(F)(F)F,,ClCCl,c1ccncc1,CCCCCC,,val
US20080167310A1,CC(C)(C)OC(=O)CCc1ccc(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cc1CBr.Oc1ccc(C(F)(F)F)cc1>>CC(C)(C)OC(=O)CCc1ccc(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cc1COc1ccc(C(F)(F)F)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04528368,N#CCCl.Nc1nnc(S)s1>>N#CCc1nnc(N)s1,,CCO,,,,val
US20150225381A1,CC(C)(C)[Si](C)(C)Cl.COC(=O)C1(O)CC1>>COC(=O)C1(O[Si](C)(C)C(C)(C)C)CC1,,ClCCl,,c1c[nH]cn1,,val
US20020086890A1,CCOC(=O)C1(S(=O)(=O)c2ccc(OCC#CCN3CCCCC3)cc2)CCN(Cc2ccc(Br)cc2)CC1>>O=C(O)C1(S(=O)(=O)c2ccc(OCC#CCN3CCCCC3)cc2)CCN(Cc2ccc(Br)cc2)CC1,,C1CCOC1,,CO,[Na+].[OH-],val
US20050119305A1,COCOC(CCCCSC(C)=O)c1ccc(-c2ccc(Cl)cc2)cc1>>CC(=O)SCCCCC(O)c1ccc(-c2ccc(Cl)cc2)cc1,,C1COCCO1,Cl,,,val
US20130231480A1,CCOC(=O)CN(CCNC(=O)OC(C)(C)C)C(=O)Cn1cnc2c(N)nc(N)nc21.O=C(NCCCBr)OCc1ccccc1>>CCOC(=O)CN(CCNC(=O)OC(C)(C)C)C(=O)Cn1cnc2c(NCCCNC(=O)OCc3ccccc3)nc(N)nc21,,CN(C)C=O,,CCN(CC)CC,,val
US05134142,CS(=O)(=O)Cl.CS(=O)(=O)c1ccc(-c2cc(C(N)=O)nn2-c2ccc(O)cc2)cc1>>CS(=O)(=O)Oc1ccc(-n2nc(C#N)cc2-c2ccc(S(C)(=O)=O)cc2)cc1,,c1ccncc1,,,,val
US20110275656A1,COC(=O)c1cc(N)c(N)cn1.S=C=Nc1c(Cl)cccc1Cl>>COC(=O)c1cc(NC(=S)Nc2c(Cl)cccc2Cl)c(N)cn1,,C1CCOC1,CO,,,val
US04496560,COC(=O)Nc1ncc(C2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)C(NC(=O)Cc4cccs4)C3SC2)s1>>COC(=O)Nc1ncc(C2=C(C(=O)O)N3C(=O)C(NC(=O)Cc4cccs4)C3SC2)s1,,O=CO,,,,val
US20140080808A1,Cc1ccnc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO[Si](C)(C)C(C)(C)C)C5)CC3)cc2)c1>>Cc1ccnc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO)C5)CC3)cc2)c1,,CO,,Cl,,val
US20120208812A1,COc1cc(N2CC3CNCC3C2)nc(N(C)C)n1.O=C(O)c1ccccc1-n1nccn1>>COc1cc(N2CC3CN(C(=O)c4ccccc4-n4nccn4)CC3C2)nc(N(C)C)n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060074056A1,CS(=O)(=O)c1ccc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)cc1>>CS(=O)(=O)c1ccc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)cc1,Cl[Ni]Cl,C1CCOC1,CO,[BH4-].[Na+],,val
US20100029643A1,NN.O=C1C=C(Cl)C(=O)O1>>O=c1cc(Cl)c(=O)[nH][nH]1,,CCO,,O,,val
US20080306122A1,C=CCNCc1ccccc1.CC(C)(C)OC(=O)N(CC(=O)O)Cc1ccccc1>>C=CCN(Cc1ccccc1)C(=O)CN(Cc1ccccc1)C(=O)OC(C)(C)C,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20140271543A1,C[C@H](Nc1nc(Cl)ncc1C(=O)O)c1ccc(F)cn1.N.On1nnc2ccccc21>>C[C@H](Nc1nc(On2nnc3ccccc32)ncc1C(N)=O)c1ccc(F)cn1,,C1COCCO1,CN(C)C=O,CCN=C=NCCCN(C)C,Cl,val
US20090306105A1,O=C(OCc1ccccc1)c1cc(O[C@H]2CCOC2)c(OCc2ccccc2)cc1[N+](=O)[O-]>>Nc1cc(OCc2ccccc2)c(O[C@H]2CCOC2)cc1C(=O)OCc1ccccc1,[Ni],,,,,val
US04536504,CCOC(=O)C1(F)C(=O)NC(=O)NC1OC(C)=O.O/N=C/c1ccco1>>CCOC(=O)C1(F)C(=O)NC(=O)NC1O/N=C/c1ccco1,,c1ccncc1,,CCN(CC)CC,O,val
US20120172599A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCCCN(CCCC)c1ccc(C=O)c(O)c1>>CCCCN(CCCC)c1ccc(C=O)c(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c1,,CCOC(C)=O,CN(C)C=O,O,c1c[nH]cn1,val
US20090306016A1,Clc1ccc(OCCCCBr)cc1.O=C1NS(=O)(=O)c2ccccc21>>O=C1c2ccccc2S(=O)(=O)N1CCCCOc1ccc(Cl)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20050049262A1,C[C@H](O)CCCCn1c(=O)c2c(ncn2Cc2ccccc2)n(C)c1=O>>C[C@H](O)CCCCn1c(=O)c2[nH]cnc2n(C)c1=O,[Pd],CO,,CC(=O)O,[H][H],val
US20040014962A1,COC(=O)C(CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)N=C=S.OC1CNC1>>COC(=O)[C@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)NC(=S)N1CC(O)C1,,C1CCOC1,O,,,val
US20040063704A1,COC(=O)c1cc([N+](=O)[O-])c(O)c(F)c1F>>COC(=O)c1cc(N)c(O)c(F)c1F,[Pd],CO,,,,val
US20030144285A1,CN1CCNCC1.N#CCCCBr>>CN1CCN(CCCC#N)CC1,,CC#N,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US20120129814A1,CC(C)Oc1ccc(C(=O)O)cc1C(F)(F)F.NC(=NO)c1ccc(CO)cc1>>CC(C)Oc1ccc(-c2nc(-c3ccc(CO)cc3)no2)cc1C(F)(F)F,,C1CCOC1,,,,val
US20080261979A1,Cc1nc(Br)sc1COc1ccc(C#N)c(Cl)c1.NO>>Cc1nc(Br)sc1COc1ccc(C(=N)NO)c(Cl)c1,,C1CCOC1,CO,CCN(CC)CC,Cl,val
US20110112103A1,COC(=O)c1cncc(OCc2ccccc2)c1>>O=C(O)c1cncc(OCc2ccccc2)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US05300647,CC1(C)CC(OC(=O)c2ccccc2)CC(C)(C)N1O.CCCCN=C=O>>CCCCNC(=O)ON1C(C)(C)CC(OC(=O)c2ccccc2)CC1(C)C,,Cc1ccccc1,,,,val
US04608374,CC1CCC(C(C)C)C(S(=O)(=O)OCCc2cccc(C(F)(F)F)c2)C1.c1ccc2c(c1)Cn1cccc1C(C1CCNCC1)O2>>FC(F)(F)c1cccc(CCN2CCC(C3Oc4ccccc4Cn4cccc43)CC2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100160388A1,CC(C)(C)[Si](C)(C)OCCBr.Nc1cc(O)c(Cl)cc1Br>>CC(C)(C)[Si](C)(C)OCCOc1cc(N)c(Br)cc1Cl,,CN1CCCC1=O,O,[I-].[Na+],O=C([O-])[O-].[Cs+].[Cs+],val
US20090291988A1,CC(C)(O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.N#CC1(c2ccc(Br)c(F)c2)CC1>>CC(C)(O)c1ccc(-c2ccc(C3(C#N)CC3)cc2F)cc1,,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20020156081A1,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1C[C@H](O)C1.O=C(O)c1ccc([N+](=O)[O-])cc1>>Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1C[C@@H](OC(=O)c2ccc([N+](=O)[O-])cc2)C1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110245255A1,Cc1nc(Cl)c(N)c(Cl)n1.NCCO>>Cc1nc(Cl)c(N)c(NCCO)n1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20130029961A1,CC(C)(C)C(=O)Nc1ccncc1.CN(C)C=O>>CC(C)(C)C(=O)Nc1ccncc1C=O,,C1CCOC1,CCCCCC,Cl,O=C([O-])[O-].[K+].[K+],val
US20070225292A1,CS(=O)(=O)Cl.O=C(NCC1CCC1)c1ncccc1NC(=O)c1ccc(CO)c2ccccc12>>CS(=O)(=O)OCc1ccc(C(=O)Nc2cccnc2C(=O)NCC2CCC2)c2ccccc12,,ClCCl,,CCN(CC)CC,,val
US20090202480A1,C=C[C@@H]1C[C@]1(N)C(=O)OCC.O=C(n1ccnc1)n1ccnc1>>C=C[C@@H]1C[C@]1(NC(=O)n1ccnc1)C(=O)OCC,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050267170A1,COC(=O)c1cc(F)cnc1C.O=C(OO)c1cccc(Cl)c1>>COC(=O)c1cc(F)c[n+]([O-])c1C,,ClCCl,,,,val
US20130168656A1,CCNCC.O=C(Cl)c1cccc(Br)c1>>CCN(CC)C(=O)c1cccc(Br)c1,,C1CCOC1,CCOC(C)=O,,,val
US20140134193A1,CC(C)(C)OC(=O)NCc1ccc(NC(=O)CNC(=O)CCCCCNC(=O)OCC2c3ccccc3-c3ccccc32)cc1.O=C(O)C(F)(F)F>>NCc1ccc(NC(=O)CNC(=O)CCCCCNC(=O)OCC2c3ccccc3-c3ccccc32)cc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20040209905A1,CCCNCC.COc1cc2ncnc(Oc3ccc(N)c(Cl)c3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCN(CC)C(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl,,CCN(CC)CC,ClC(Cl)Cl,CO,,val
US20100041721A1,CCOC(=O)c1ccc(OCc2ccc(OC)cc2)cc1.NN>>COc1ccc(COc2ccc(C(=O)NN)cc2)cc1,,CCO,,O,,val
US20130183269A1,CCOC(=O)C1(NCCO)CC1.O=C(n1ccnc1)n1ccnc1>>CCOC(=O)C1(N2CCOC2=O)CC1,,C1CCOC1,,,,val
US07179823B1,CCOC(=O)CCc1c[nH]nc1OCC.ClCc1ccc(OCc2cccnc2)cc1>>CCOC(=O)CCc1cn(Cc2ccc(OCc3cccnc3)cc2)nc1OCC,,O,,CN(C)C=O,[H-].[Na+],val
US04196127,CCOC(=O)CC(=O)OCC.CCOc1ccc(OCC)c(C=O)c1>>CCOC(=O)C(=Cc1cc(OCC)ccc1OCC)C(=O)OCC,,O,c1ccccc1,C1CCNCC1,CC(=O)O,val
US20040209857A1,C=CCBr.COc1cc(CC(=O)OCc2ccccc2)c(S(=O)(=O)N2CCOCC2)cc1OC>>C=CCC(C(=O)OCc1ccccc1)c1cc(OC)c(OC)cc1S(=O)(=O)N1CCOCC1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20020099007A1,Cn1cncc1C(N)(CCCNCCc1cccc(O)c1)c1ccc(C#N)c(F)c1>>Cn1cncc1C1(N)CCCNCCc2cccc(c2)Oc2cc1ccc2C#N,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04654162,CCC[C@@H]1CC[C@@H](c2ccc(O)cc2)CC1.OCCBr>>CCC[C@@H]1CC[C@@H](c2ccc(OCCO)cc2)CC1,,CCO,O,[K+].[OH-],,val
US20160228450A1,CC(C)(C)c1ccc(C(=O)N[C@@H](Cc2ccc(-c3ncc(Br)cn3)cc2)C(=O)O)s1.OB(O)c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1>>CC(C)(C)c1ccc(C(=O)N[C@@H](Cc2ccc(-c3ncc(-c4ccc(-c5ccc(OC(F)(F)F)cc5)cc4)cn3)cc2)C(=O)O)s1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20100234285A1,CCOC(=O)c1cc(O)c2cc(C)oc2c1.CN(C)C(=O)c1cnc(Cl)cn1>>CCOC(=O)c1cc(Oc2cnc(C(=O)N(C)C)cn2)c2cc(C)oc2c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04665075,CCOC(=O)Nc1ccc(OCc2ccccc2)cc1C(=O)NCCN1CCC(C(=O)c2ccc(F)cc2)CC1>>O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3ccc(OCc4ccccc4)cc3c2=O)CC1,,O,,[K+].[OH-],,val
US04248620,CN1C(=O)C(=NC(Cl)CCl)N(c2ccccc2F)C1=O.Nc1ccccc1Cl>>CN1C(=O)C(=NC(CCl)Nc2ccccc2Cl)N(c2ccccc2F)C1=O,,CC#N,CCOCC,CCN(CC)CC,Cl,val
US20060293300A1,CC(NC(=O)c1ccc(Cl)s1)C(=O)O.CCN(C(C)C)C(C)C.CCN1CCN(C(=O)c2ccc(N)cc2)CC1>>CCN1CCN(C(=O)c2ccc(NC(=O)C(C)NC(=O)c3ccc(Cl)s3)cc2C)CC1,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20100056524A1,CC(O)c1cccc([N+](=O)[O-])c1.O=S(Cl)Cl>>CC(Cl)c1cccc([N+](=O)[O-])c1,,ClCCl,,,,val
US20110077273A1,COC(=O)c1ccc(COc2ncccc2-c2nc3cc(F)c(F)cc3n2CC2CCCCC2)cc1>>O=C(O)c1ccc(COc2ncccc2-c2nc3cc(F)c(F)cc3n2CC2CCCCC2)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20150266881A1,Cl.N[C@@H]1C[C@H]1c1cccc(C(=O)NC2CCOCC2)c1.O=C1CCC(F)(F)CC1>>Cl.O=C(NC1CCOCC1)c1cccc([C@@H]2C[C@H]2NC2CCC(F)(F)CC2)c1,,CC(=O)O,CO,O=C([O-])O.[Na+],,val
US20030096812A1,CC1CN(Cc2ccccc2)CC(C)C1=O.CCOC(=O)Cl>>CCOC(=O)N1CC(C)C(=O)C(C)C1,,c1ccccc1,,,,val
US04472305,CSCC[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(N)=O>>CSCC[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1)C(N)=O,,CC(=O)O,,Cl,,val
US04762844,CO.Cc1c(Cl)cc(C(=O)O)c(Cl)c1N>>COC(=O)c1cc(Cl)c(C)c(N)c1Cl,,O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20160222028A1,COC(=O)c1ccc(CBr)c(Br)c1.C[C@@H](N)CO>>COC(=O)c1ccc(CN[C@H](C)CO)c(Br)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130231328A1,CC(C)(C)OC(=O)NC1CCC(Oc2ncnc3sc4c(c23)C[C@H](CCO[Si](C)(C)C(C)(C)C)CC4)CC1>>CC(C)(C)OC(=O)NC1CCC(Oc2ncnc3sc4c(c23)C[C@H](CCO)CC4)CC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05631257,CI.CN1CCN(c2nc3ccccc3o2)CC1>>C[N+]1(C)CCN(c2nc3ccccc3o2)CC1.[I-],,CN(C)C=O,,,,val
US20160251339A1,COc1ccc(S(=O)(=O)n2cc(C(=O)C(F)(F)F)c3ccc(F)cc32)cc1N1CCN(C(=O)C(F)(F)F)CC1>>COc1ccc(S(=O)(=O)n2cc(C(O)C(F)(F)F)c3ccc(F)cc32)cc1N1CCNCC1,,CCO,,O,[BH4-].[Na+],val
US20100173901A1,CN.Cc1cc(Br)ccc1C(=O)O>>CNC(=O)c1ccc(Br)cc1C,,CN(C)C=O,ClCCl,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20110190263A1,CCc1cnc(Cl)nc1.OCC1CCNCC1>>CCc1cnc(N2CCC(CO)CC2)nc1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100093731A1,COc1cc(Nc2nc(Cl)nc(N(C)C)n2)ccc1-n1cnc(C)c1.Oc1ccccc1C(F)(F)F>>COc1cc(Nc2nc(Oc3ccccc3C(F)(F)F)nc(N(C)C)n2)ccc1-n1cnc(C)c1,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20130197178A1,BrBr.O=C(O)/C=C/c1c(F)cccc1F>>Fc1cccc(F)c1/C=C\Br,,ClCCl,,,,val
US20100113270A1,CCc1ccc(Br)cc1[N+](=O)[O-]>>CCc1ccc(Br)cc1N,[Zn],CO,O,[Cl-].[NH4+],,val
US20020128301A1,CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O.COc1ccc(COC(=O)C(C)O)cc1>>COc1ccc(COC(=O)C(C)OC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05859007,COc1ccc(N(C(=O)CN2C(=O)CC(=O)Nc3ccccc32)C(C)C)cc1.Fc1cccc(Br)c1>>COc1ccc(N(C(=O)CN2C(=O)CC(=O)N(c3cccc(F)c3)c3ccccc32)C(C)C)cc1,,CN(C)C=O,,ClCCl,CC(=O)[O-].[K+],val
US20120328569A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cccc(C#C[Si](C)(C)C)c3)cc12>>C#Cc1cccc(-c2cc3c(C(=O)NC)c(-c4ccc(F)cc4)oc3cc2N(C)S(C)(=O)=O)c1,,CO,O,[F-].[K+],,val
US20120238545A1,C1COCCN1.CCOC(=O)c1nn(-c2cccc(CO)c2)c2c1CS(=O)(=O)c1ccccc1-2>>O=C(c1nn(-c2cccc(CO)c2)c2c1CS(=O)(=O)c1ccccc1-2)N1CCOCC1,,C1CCOC1,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20150158847A1,COc1ccc(COc2cc(F)c(CNc3ccc(I)cc3N)cc2OC)cn1>>Ic1ccc2[nH]cnc2c1,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US06147097,CN(C)C=O.Cc1cc(C)cc(Sc2c(C(C)C)ncn2C)c1>>Cc1cc(C)cc(Sc2c(C(C)C)nc(C=O)n2C)c1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US04362546,CCCCNC.O=C1C2=CC(CCC2)C(=O)N1c1ccc(Cl)cc1>>CCCCN(C)C(=O)C1=C(C(=O)Nc2ccc(Cl)cc2)CCCC1,,CC(C)=O,,CCOCC,FB(F)F,val
US20060160857A1,Nc1c(F)cccc1F.S=C(Cl)Cl>>Fc1cccc(F)c1N=C=S,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160009714A1,C[C@H]1CN(c2ccncc2NC(=O)c2ccc3ccc(C4=CCOCC4)cc3n2)C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C>>C[C@H]1CN(c2ccncc2NC(=O)c2ccc3ccc(C4CCOCC4)cc3n2)C[C@@H](N)[C@@H]1O,[Pd],CO,,C1COCCO1,Cl,val
US04806685,COCOc1ccc(C(=C(c2ccc(OCOC)cc2)C(F)(F)F)c2ccc(OCCN(C)C)cc2)cc1.Cl>>CN(C)CCOc1ccc(C(=C(c2ccc(O)cc2)C(F)(F)F)c2ccc(O)cc2)cc1.Cl,,CO,,,,val
US20020137205A1,NCCO.O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1>>O=[N+]([O-])c1ccc(NCCO)c([N+](=O)[O-])c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080039462A1,O=S(=O)(O)O.c1ccc(N2CCCC2)cc1>>O=S(=O)(O)c1ccc(N2CCCC2)cc1,,CCOCC,,,,val
US20160244431A1,CC(C)(C)OC(=O)NCCc1ccc(NC(=O)CCl)cc1.c1ccc(CNCc2ccccc2)cc1>>CC(C)(C)OC(=O)NCCc1ccc(NC(=O)CN(Cc2ccccc2)Cc2ccccc2)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US04186019,Nc1ccccn1.O=S(=O)(O)Cl.c1ccccc1>>O=S(=O)(Nc1ccccn1)c1ccccc1,,C1CCOC1,,O,,val
US20080234371A1,CC(=O)[O-].CC(=O)[O-].C[N+](C)(C)C[C@H](O)CC(=O)[O-].[Ca+2]>>CC(=O)[O-].CC(=O)[O-].C[N+](C)(C)C[C@H](O)CC(=O)[O-].[Ca+2],,O,,,,val
US20080039459A1,CN(C)S(=O)(=O)CCCN.O=Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1>>CN(C)S(=O)(=O)CCCNCc1cc2nc(Cl)nc(N3CCOCC3)c2s1,[Pd],CCO,CO,,,val
US20120108574A1,O=C1CCC(=O)N1Br.c1ccc(CCc2cn3c(n2)-c2ccccc2Nc2ncccc2-3)cc1>>Brc1c(CCc2ccccc2)nc2n1-c1cccnc1Nc1ccccc1-2,,C1CCOC1,,,,val
US20080255122A1,CC(C)(C)OC(=O)Nc1ccc(CBr)cn1.CN(C)C=O.Nc1ccc(N2CCNCC2)cc1.O=C1NS(=O)(=O)C(c2ccccc2)=C1Cl>>CC(C)(C)OC(=O)Nc1ccc(CN2C(=O)C(Nc3ccc(N4CCOCC4)cc3)=C(c3ccccc3)S2(=O)=O)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040076580A1,CC(=O)SCC(=O)Oc1c(F)c(F)c(F)c(F)c1F.NCC(=O)NCC(=O)NCC(=O)O>>CC(=O)SCC(=O)NCC(=O)NCC(=O)NCC(=O)O,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20140171422A1,CN.Cc1nc2c(Br)cccc2c(=O)o1>>Cc1nc2c(Br)cccc2c(=O)n1C,,C1CCOC1,,,,val
US20040097509A1,CSc1ccc(S)cc1.O=Cc1ccncc1Cl>>CSc1ccc(Sc2cnccc2C=O)cc1,,CN(C)C=O,,,,val
US20080312208A1,CCOC(=O)c1cc(Cl)c(Cl)nc1C.O=C(NS(=O)(=O)Cc1ccccc1)C1CNC1>>CCOC(=O)c1cc(Cl)c(N2CC(C(=O)NS(=O)(=O)Cc3ccccc3)C2)nc1C,,CCO,ClCCl,CC#N,O,val
US05426119,COC(=O)CCCC=C(c1cccnc1)c1ccc2c(c1)CC(NS(=O)(=O)c1ccc(Br)cc1)C2>>O=C(O)CCCC=C(c1cccnc1)c1ccc2c(c1)CC(NS(=O)(=O)c1ccc(Br)cc1)C2,,CCO,,,,val
US20090137603A1,O=C(NCc1cccc(OCCOc2ncn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)c1)c1nc2ccc(F)c(F)c2c(=O)[nH]1>>O=C(NCc1cccc(OCCOc2nc[nH]n2)c1)c1nc2ccc(F)c(F)c2c(=O)[nH]1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20150210722A1,O=[N+]([O-])c1ccc(Oc2ccnc(Cl)n2)c2cccnc12>>Nc1ccc(Oc2ccnc(Cl)n2)c2cccnc12,[Fe],CC(C)O,O,[Cl-].[NH4+],,val
US07939537B2,COC(=O)C#CC(=O)OC.Nc1cccc[n+]1[O-]>>COC(=O)/C=C(\Nc1cccc[n+]1[O-])C(=O)OC,,ClC(Cl)Cl,,,,val
US20140378459A1,CC(C)(C)OC(=O)CBr.CC(C)(C)OC(=O)c1ccc(CCNC(=O)OCc2ccccc2)cc1>>CC(C)(C)OC(=O)CN(CCc1ccc(C(=O)OC(C)(C)C)cc1)C(=O)OCc1ccccc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20080207608A1,CCOC(=O)C(=O)Nc1ccc(C(=O)C=Cc2cnc3ccccc3n2)cc1.NCCN1CCOCC1>>O=C(NCCN1CCOCC1)C(=O)Nc1ccc(C(=O)C=Cc2cnc3ccccc3n2)cc1,,Cc1ccccc1C,,,,val
US20160052898A1,CCI.O=C(CN1CCOCC1)Nc1cc(C(=O)Nc2ccc(-c3ccccc3)cc2)ccc1O>>CCOc1ccc(C(=O)Nc2ccc(-c3ccccc3)cc2)cc1NC(=O)CN1CCOCC1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US06555694B1,Nc1ccc(Br)cc1.O=C(O)C1(C(=O)O)CC1>>O=C(O)C1CCN(c2ccc(Br)cc2)C1=O,,CC#N,,,,val
US05210218,CC(C)(C)N.CC1(C=O)C(c2ccccc2)C1(Cl)Cl>>C=NC(C)(C)C.CC1C(c2ccccc2)C1(Cl)Cl,,c1ccccc1,,O=S(=O)([O-])[O-].[Na+].[Na+],,val
US04772600,CNC.COc1ccc(-c2nc3cccnc3n2CC(=O)O)cc1>>COc1ccc(-c2nc3cccnc3n2CC(=O)N(C)C)cc1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20140349991A1,CCN1CCC[C@@H]1c1oc2c(C)c(OC(C)=O)ccc2c(=O)c1C>>CCN1CCC[C@@H]1c1oc2c(C)c(O)ccc2c(=O)c1C,,CO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20140275071A1,CC(O)CCn1c(=O)c2c(nc(Oc3cccc(OC(F)(F)F)c3)n2COCC[Si](C)(C)C)n(C)c1=O>>CC(O)CCn1c(=O)c2[nH]c(Oc3cccc(OC(F)(F)F)c3)nc2n(C)c1=O,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150218139A1,CNC(=S)N(C)C(=O)OC.O=C(Nc1cc2c(cc1F)OC(F)(F)C(=O)N2)Oc1ccccc1>>Cn1c(=S)n(C)c(=O)n(-c2cc3c(cc2F)OC(F)(F)C(=O)N3)c1=O,,CN(C)C=O,,CC(=O)[O-].[Na+],,val
US20070244131A1,CCC(CC)(C(=O)[O-])C(=O)[O-].CCO.COCC(=N)N>>COCc1nc(O)cc(O)n1,,CCO,,Cl,[H-].[Na+],val
US20150252034A1,COc1ccc(CN(c2cccc(F)n2)S(=O)(=O)c2cc3oc(=O)[nH]c3cc2F)c(OC)c1.C[C@H](O)c1ccccc1I>>C[C@H](c1ccccc1I)n1c(=O)oc2cc(S(=O)(=O)Nc3cccc(F)n3)c(F)cc21,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040152714A1,COc1cc(CNc2nc(C)nc(C)c2Cl)ccc1OCc1ccccc1>>COc1cc(CNc2nc(C)nc(C)c2Cl)ccc1O,,CCO,,Cl,,val
US20130217671A1,CC(=O)c1cnc2ccc(Br)cc2c1N[C@@H]1CC[C@@H](N(C)C)CC1.CC1(C)OB(c2cc(Cl)c(O)c(Cl)c2)OC1(C)C.Cl>>CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)cc2c1N[C@@H]1CC[C@@H](N(C)C)CC1.Cl,,CO,ClCCl,,,val
US20020049243A1,CI.CN(CC(=O)N(C)c1ccc(CO)cc1)C(=O)OCc1ccccc1>>COCc1ccc(N(C)C(=O)CN(C)C(=O)OCc2ccccc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20130303533A1,CCOC(=O)CC#N.COS(=O)(=O)OC.NC(N)=S>>CSc1nc(N)cc(O)n1,,CCO,O,[Na],,val
US20080015199A1,CCOC(=O)c1c(NNC(=O)OC(C)(C)C)ncn1Cc1ccccc1>>CCOC(=O)c1c(NN)ncn1Cc1ccccc1,,Cc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,val
US05886033,N#CC(C(=O)Nc1ccc(C#N)cc1)=C(O)C1CC1.NCCCC[C@H](N)C(=O)O>>N#CC(C(=O)Nc1ccc(C#N)cc1)=C(O)C1CC1.NCCCC[C@H](N)C(=O)O,,O,,CCO,,val
US20110230463A1,COC(=O)c1cnc(Cl)c(Cl)c1.OC(CF)CF>>COC(=O)c1cnc(OC(CF)CF)c(Cl)c1,,C1CCOC1,,[H-].[Na+],,val
US20050119326A1,COC(=O)c1ccc(OCCCON)cc1O.O=Cc1cc2ccccc2n1Cc1ccccc1>>COC(=O)c1ccc(OCCCO/N=C/c2cc3ccccc3n2Cc2ccccc2)cc1O,,ClCCl,,O=S(=O)([O-])[O-].[Mg+2],,val
US20080275032A1,CC(C)(C)C[Mg]Cl.CCOC(=O)C(=O)OCC>>CCOC(=O)C(=O)CC(C)(C)C,,C1CCOC1,,,,val
US20100197725A1,CCCC(CCC)N1CCc2c(C(=O)N[C@@H](Cc3cc(F)cc(F)c3)[C@H](O)CNC3(c4cccc(C(F)(F)F)c4)CC3)cc(NS(C)(=O)=O)cc2C1=O.Cl>>CCCC(CCC)N1CCc2c(C(=O)N[C@@H](Cc3cc(F)cc(F)c3)[C@H](O)CNC3(c4cccc(C(F)(F)F)c4)CC3)cc(NS(C)(=O)=O)cc2C1=O.Cl,,C1COCCO1,CCOCC,,,val
US20080194561A1,NCCO.O=C(CCl)Nc1ccc([N+](=O)[O-])cc1>>O=C(CNCCO)Nc1ccc([N+](=O)[O-])cc1,,CO,,,,val
US05140031,CC1(C)Oc2ccc(C#N)cc2C2OC21.NCCN>>CC1(C)Oc2ccc(C#N)cc2[C@@H](NCCN)[C@@H]1O,,CCO,,,,val
US04564694,CC(CCCC1CCCCC1)c1ccc(CCC(=O)O)cc1>>CC(CCCC1CCCCC1)c1ccc(CCCO)cc1,,CCOCC,,,,val
US03992535,CCOC(=O)CCl.O=C1NS(=O)(=O)c2c1ccc1ccccc21>>CCOC(=O)CN1C(=O)c2ccc3ccccc3c2S1(=O)=O,,CCO,,[Na],,val
US20080206548A1,CC12CC3CC(C)(C1)CC(Br)(C3)C2.Oc1ccccc1>>CC12CC3CC(C)(C1)CC(C1(O)C=CC=CC1)(C3)C2,,O,,[Na+].[OH-],,val
US20150232445A1,Brc1csc(Br)n1.CC(C)(C)OC(=O)N1CC(=O)C1>>CC(C)(C)OC(=O)N1CC(O)(c2nc(Br)cs2)C1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20030176454A1,Cc1ccc(N)cc1-c1cncnc1.Clc1nccc2c(-n3cccc3)cccc12>>Cc1ccc(Nc2nccc3c(-n4cccc4)cccc23)cc1-c1cncnc1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20040242884A1,CNCC(O)c1ncccn1.Cc1c(CCl)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12>>Cc1c(CN(C)CC(O)c2ncccn2)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20070027145A1,C1O[C@@H]2CNC[C@@H]2O1.OCCBr>>OCCN1C[C@H]2OCO[C@H]2C1,,CC#N,CO,Cl,O=C([O-])[O-].[K+].[K+],val
US20080089932A1,CCOC(=O)C(C)(C)C(=O)O.NCCN1CCOCC1>>CCOC(=O)C(C)(C)C(=O)NCCN1CCOCC1,,C1CCOC1,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20050245581A1,CC(=O)Oc1ccc(Cl)nc1.CCCC[Sn](CCCC)(CCCC)c1cc(-c2ccccc2C#N)c(=O)n(-c2ccccc2)c1>>CC(=O)Oc1ccc(-c2cc(-c3ccccc3C#N)c(=O)n(-c3ccccc3)c2)nc1,,CCCCCC,CCOC(C)=O,Cc1ccccc1C,,val
US20050215801A1,O=C(NC[C@H](O)CBr)c1ccccc1>>O=C(NC[C@H]1CO1)c1ccccc1,,CO,,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US05239075,C=CC(C)=O.CC(=O)O.CC1=C(NC(C)c2ccccc2)CCc2cc(Cl)ccc21>>CC1(O)CC[C@]2(C)C(=O)C1Cc1cc(Cl)ccc12,,C1CCOC1,,,,val
US20040087798A1,Brc1cncnc1.COc1ccccc1B(O)O>>COc1ccccc1-c1cncnc1,[Pd],CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US05272163,CC(O)(C(=O)O)C(F)(F)F.N#Cc1cc(N)ccc1Sc1ccccc1>>CC(O)(C(=O)Nc1ccc(Sc2ccccc2)c(C#N)c1)C(F)(F)F,,CC(=O)N(C)C,,O,O=S(Cl)Cl,val
US20050256140A1,CN(C)C(=O)OC(c1ccccc1)c1nc(-c2ccccc2)c(-c2nc3c(N)ncnc3s2)n1C>>Cn1c(C(O)c2ccccc2)nc(-c2ccccc2)c1-c1nc2c(N)ncnc2s1,,C1CCOC1,CCOC(C)=O,O,O=C(O)C(F)(F)F,val
US20140088075A1,CCOC(=O)Cc1cc([N+](=O)[O-])c(F)cc1Br>>CCOC(=O)Cc1cc(N)c(F)cc1Br,[Fe],CCO,,[Cl-].[NH4+],,val
US06235786B1,CC1CO1.CS(=O)(=O)c1ccc(Oc2ccccc2)cc1>>CC(O)CCS(=O)(=O)c1ccc(Oc2ccccc2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20100227859A1,CC(C)(C)C(=O)OC(=O)C(C)(C)C.N=C(NO)c1ccc2oc3cc([N+](=O)[O-])ccc3c2c1>>CC(C)(C)c1nc(-c2ccc3oc4cc([N+](=O)[O-])ccc4c3c2)no1,,ClCCl,,,,val
US20050054670A1,CC(C)(C)c1ccc(N2Cc3cccc(C=Cc4ccncc4)c3C2=O)cc1>>CC(C)(C)c1ccc(N2Cc3cccc(CCc4ccncc4)c3C2=O)cc1,[Pd],CCO,,,,val
US20110071115A1,CSc1nc(Cl)n2nccc2n1.NC1CC1>>CSc1nc(NC2CC2)n2nccc2n1,,CN1CCCC1=O,,O,,val
US20140275071A1,C=CCn1cnc2c1c(=O)[nH]c(=O)n2CC.O=C1CCC(=O)N1Cl>>C=CCn1c(Cl)nc2c1c(=O)[nH]c(=O)n2CC,,CN(C)C=O,,,,val
US05948793,C=CCBr.O=C1CC[C@@H](COc2cccnc2)N1>>C=CCN1C(=O)CC[C@H]1COc1cccnc1,,C1CCOC1,,[H-].[Na+],,val
US20140094453A1,CC(C)(C)OC(=O)N1CCC[C@H](COc2cccc([N+](=O)[O-])c2C#N)C1.Cl>>Cl.N#Cc1c(OC[C@H]2CCCNC2)cccc1[N+](=O)[O-],,C1COCCO1,,,,val
US04284426,CCOC(=O)c1sc(Cl)nc1-c1ccc(Cl)cc1>>OCc1sc(Cl)nc1-c1ccc(Cl)cc1,,CCO,,[BH4-].[Na+],,val
US04962103,COc1ccc(COC(=O)[C@@H]2C[C@@H](O)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)cc1.O=C(Cl)c1ccccc1>>COc1ccc(COC(=O)[C@@H]2C[C@@H](OC(=O)c3ccccc3)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)cc1,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,,val
US20160009744A1,COc1ccc(CS)cc1.Clc1ccc(CBr)c(Br)c1>>COc1ccc(CSCc2ccc(Cl)cc2Br)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110190272A1,CC(=O)OC(C)=O.COc1cc2nnc(C(N)=O)c(Nc3ccc(C)cc3F)c2cc1N1C[C@H](C)N[C@H](C)C1>>COc1cc2nnc(C(N)=O)c(Nc3ccc(C)cc3F)c2cc1N1C[C@H](C)N(C(C)=O)[C@H](C)C1,,CN(C)C=O,,CCN(CC)CC,,val
US05708187,CCOC(=O)C=[N+]=[N-].NC1CCC(=O)CC1>>CCOC(=O)C1CCC(N)CCC1=O,,CCOCC,,FB(F)F,,val
US05721248,Cc1ccnc2ccc(-c3ccccc3)cc12.O=[Se]=O>>O=Cc1ccnc2ccc(-c3ccccc3)cc12,,C1COCCO1,,O,,val
US20070298104A1,COC(=O)c1ncc2cccc(Oc3ccccc3)c2c1O.O=C1CCC(=O)N1Br>>COC(=O)c1nc(Br)c2cccc(Oc3ccccc3)c2c1O,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20100152163A1,CN1CCc2c(n(CC(OS(C)(=O)=O)c3ccccc3F)c3ccc(Cl)cc23)CC1>>CN1CCc2c(n(CCc3ccccc3F)c3ccccc23)CC1,[Pd],CO,,O,,val
US20080194624A1,CCOc1cc([N+](=O)[O-])c(C=C(C#N)C(CCC(=O)NCCC(C)(C)C)C2CCOCC2)cc1Oc1ccccc1.Cl>>CCOc1cc2nc(N)c(C(CCC(=O)NCCC(C)(C)C)C3CCOCC3)cc2cc1Oc1ccccc1.Cl,[Zn],CO,,[Cl-].[NH4+],,val
US20110217311A1,COC(=O)c1sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCCC[C@@H]3OC)c2c1C>>CO[C@H]1CCCC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)O)c(C)c12,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20120122842A1,O=C(Nc1ccc(-c2n[nH]c(=O)c3cccn23)cc1)Oc1ccccc1.c1ccc2c(c1)CNC2>>O=C(Nc1ccc(-c2n[nH]c(=O)c3cccn23)cc1)N1Cc2ccccc2C1,,CCOC(C)=O,CS(C)=O,,,val
US20080176857A1,CCc1cc2c(N3CCNCC3)nc(SCC(=O)OC)nc2s1.Cc1cccc(C(=O)Cl)c1>>CCc1cc2c(N3CCN(C(=O)c4cccc(C)c4)CC3)nc(SCC(=O)OC)nc2s1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US06242443B1,CCC(CC)N=C=S.Nc1cc(Cl)ccc1S(N)(=O)=O>>CCC(CC)NC1=NS(=O)(=O)c2ccc(Cl)cc2N1,,CCOC(C)=O,,,,val
US05547983,CN(C)C(=O)c1ccc(-c2ccc3cc(C(=O)OCc4ccccc4)ccc3c2)cc1C12CC3CC(CC(C3)C1)C2>>CN(C)C(=O)c1ccc(-c2ccc3cc(C(=O)O)ccc3c2)cc1C12CC3CC(CC(C3)C1)C2,,CO,,[Na+].[OH-],,val
US20120071514A1,CC(O)c1ccncc1Br.CI>>COC(C)c1ccncc1Br,,CN(C)C=O,,[H-].[Na+],,val
US08119627B2,O=C(Cl)C1CCCC1.O=C(NC1CCNCC1)c1ccccc1Oc1ccc(Cl)cc1Cl>>CC(C)CC(=O)N1CCC(NC(=O)c2ccccc2Oc2ccc(Cl)cc2Cl)CC1,,ClCCl,,CCN(CC)CC,,val
US06114334,C=CCn1c(-c2cccnc2)n[nH]c1=O.ClCCCCBr>>C=CCn1c(-c2cccnc2)nn(CCCCCl)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20120190654A1,COc1ccc(CN2Cc3c(Cl)ccnc3NC2=O)cc1.Cn1nc(N)c2ccc(O)cc21>>COc1ccc(CN2Cc3c(Oc4ccc5c(N)nn(C)c5c4)ccnc3NC2=O)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120309754A1,CCOC(=O)CC(=O)Nc1cc(-c2nc3ccccc3nc2C)n[nH]1.CN(C)c1ccncc1>>CN(C)c1ccncc1.Cc1nc2ccccc2nc1-c1cc2nc(O)cc(O)n2n1,CN(C)c1ccncc1,O,,CCOC(C)=O,CO,val
US20100105747A1,Cc1ccccc1[C@H]1[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CC[C@@H]1O[C@H](COC(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>Cc1ccccc1[C@H]1[C@@H]2CNC[C@H]2CC[C@@H]1O[C@H](COC(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,C1COCCO1,,Cl,,val
US20080015199A1,CC(=O)O.COCCOc1cc(OC)cc(C(Nc2ccc(-c3noc(C(F)(F)F)n3)cc2)c2nn(-c3ncccc3[N+](=O)[O-])c(=O)[nH]2)c1F>>CC(=O)O.COCCOc1cc(OC)cc(C(Nc2ccc(C(=N)N)cc2)c2nn(-c3ncccc3N)c(=O)[nH]2)c1F,[Fe],CC(=O)O,,CO,O,val
US20050250782A1,Cc1c(Nc2ccc(Br)cc2F)c(C(=O)NN)cn(C)c1=O.O=C(n1ccnc1)n1ccnc1>>Cc1c(Nc2ccc(Br)cc2F)c(-c2n[nH]c(=O)o2)cn(C)c1=O,,CCOC(C)=O,CN(C)C=O,,,val
US20140011798A1,CN(C)C=O.Cc1cc(C#N)ccc1Br>>Cc1cc(C#N)ccc1C=O,,C1CCOC1,,,,val
US20030207865A1,CCCc1ccccc1N.II>>CCCc1cc(I)ccc1N,,CO,O,O=C([O-])O.[Na+],,val
US20090029903A1,CCCCCCNc1ccc(F)c(C(=O)OC)c1.CCCCc1ccc(C#Cc2ccc(C(=O)Cl)cc2)cc1>>CCCCCCN(C(=O)c1ccc(C#Cc2ccc(CCCC)cc2)cc1)c1ccc(F)c(C(=O)OC)c1,CN(C)c1ccncc1,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,,val
US05451582,CC(C)(C)C(=O)c1ccccc1[N+](=O)[O-]>>CC(C)(C)C(=O)c1ccccc1N,[Pd],CCO,Cl,,,val
US20140302987A1,CCc1ccc(C(c2ccc(CC)o2)c2ccc(OC)cc2C(=O)O)o1.N>>COc1cccc(C(N)=O)c1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060167065A1,O=C(NCCCl)Nc1ccc(C(F)(F)F)cc1>>O=C1NCCN1c1ccc(C(F)(F)F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050154045A1,Cl.O=C(Nc1ccc(Br)cc1)C1CN2CCC1CC2.OCc1ccc(B(O)O)cc1>>Cl.O=C(Nc1ccc(-c2ccc(CO)cc2)cc1)C1CN2CCC1CC2,,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(O)cc(C)c21.N#Cc1cncc(Cl)n1>>CCOC(=O)CC1OB(O)c2cc(Oc3cncc(C#N)n3)cc(C)c21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080064720A1,NC(=O)C(Cc1ccc2nc(-c3c(Cl)cccc3Cl)ccc2c1)NC(=O)c1c(Cl)cccc1Cl>>N#CC(Cc1ccc2nc(-c3c(Cl)cccc3Cl)ccc2c1)NC(=O)c1c(Cl)cccc1Cl,,c1ccncc1,,Cc1ccc(S(=O)(=O)Cl)cc1,,val
US05602121,ClP(Cl)(Cl)(Cl)Cl.O=C1Nc2cc(Cl)ccc2Oc2ccccc21>>ClC1=Nc2cc(Cl)ccc2Oc2ccccc21,,Cc1ccccc1,,,,val
US04154834,CCOC(=O)C=Cc1nccs1>>CCOC(=O)CCc1nccs1,[Pd],CCO,,,,val
US20120040998A1,C[C@H]1CC[C@@H](C(N)=NO)CN1C(=O)OC(C)(C)C.O=C(Cl)c1ccc(F)cc1>>C[C@H]1CC[C@@H](C(N)=NOC(=O)c2ccc(F)cc2)CN1C(=O)OC(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160100579A1,COC(c1ccc(Cl)cc1)C(C)N.O=C(Cl)c1c(F)cccc1F>>COC(c1ccc(Cl)cc1)C(C)NC(=O)c1c(F)cccc1F,,ClCCl,,CCN(CC)CC,Cl,val
US20090042892A1,BrC(Br)(Br)Br.O=S(=O)(Oc1cc2c(cc1CO)CCCC2)C(F)(F)F>>O=S(=O)(Oc1cc2c(cc1CBr)CCCC2)C(F)(F)F,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050070584A1,C1CCOC1.CO.COC(=O)c1ccc(OCCCO/N=C/c2ccc(C(F)(F)F)cc2)cc1NC(=O)c1ccc(OC(F)(F)F)cc1>>O=C(Nc1cc(OCCCO/N=C/c2ccc(-c3ccccc3)cc2)ccc1C(=O)O)c1ccc(OC(F)(F)F)cc1,,C1CCOC1,,[Li+].[OH-],,val
US04246405,Cc1ccc(S(=O)(=O)OC2=C(C(=O)OCc3ccc([N+](=O)[O-])cc3)N3C(=O)C(NC(=O)Cc4ccccc4)[C@H]3SC2)cc1>>O=C(Cc1ccccc1)NC1C(=O)N2C(C(=O)O)=CCS[C@H]12,[Zn],O=CO,,,,val
US20140288123A1,CC(C)(C)OC(=O)c1ccc(CCc2ccccc2)cc1>>O=C(O)c1ccc(CCc2ccccc2)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20140275070A1,COc1cc2[nH]c(C#N)cc2cc1CN1CCC(Nc2ncnc3sc(CC(F)(F)F)cc23)CC1>>N#Cc1cc2cc(CN3CCC(Nc4ncnc5sc(CC(F)(F)F)cc45)CC3)c(O)cc2[nH]1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20130172341A1,COC(=O)C1C(OS(C)(=O)=O)CC2CCC1N2C(=O)OC(C)(C)C>>COC(=O)C1=CCC2CCC1N2C(=O)OC(C)(C)C,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US04695571,CCN1C(=O)Cc2ccc(O)cc21.O=C(CCl)OC(=O)CCl>>CCN1C(=O)Cc2ccc(OC(=O)CCl)cc21,CN(C)c1ccncc1,ClCCl,,,,val
US04766246,CC1CCC(C)(C)C1OC(=O)[C@@H](CO)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(Cc1ccccc1)C(=O)O>>CC1CCC(C)(C)C1OC(=O)[C@@H](CO)NC(=O)[C@@H](N)CC(=O)O,[Pd],CO,,,,val
US20010011101A1,CN(C)CCS(=O)(=O)CC(Cc1ccccc1)C(=O)OCc1ccccc1>>CN(C)CCS(=O)(=O)CC(Cc1ccccc1)C(=O)O,[Pd],CCO,,,,val
US20090239848A1,CCOC(=O)C(C)C(=O)OCC.CO>>COC(=O)C(C)C(=O)O,,CO,,[K+].[OH-],,val
US20110190489A1,C[Si](C)(C)CCOCn1ccc2c(NC3CCCCC3)c(C(=O)O)cnc21.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>C[Si](C)(C)CCOCn1ccc2c1ncc1[nH]c(=O)n(C3CCCCC3)c12,,C1COCCO1,,ClCCl,O=C([O-])O.[Na+],val
US20130281412A1,COc1ccc(C(=O)Nc2ccc(Cl)cc2F)c(O)c1.Fc1ccc(CBr)c(F)c1>>COc1ccc(C(=O)Nc2ccc(Cl)cc2F)c(OCc2ccc(F)cc2F)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20020077337A1,CC(C)CI.O=C(O)c1cccc(S(=O)(=O)O)c1>>CC(C)CS(=O)(=O)c1cccc(C(=O)O)c1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20110294807A1,CC(=O)Oc1c(C)cc(C(=O)Cl)cc1C.Nc1ccncc1C(=O)O>>CC(=O)Oc1c(C)cc(-c2nc3ccncc3c(=O)o2)cc1C,,ClCCl,,c1ccncc1,,val
US20050261348A1,Clc1cc(N2CC3CNC3C2)cnc1Cl.O=C(O)/C=C\C(=O)O>>Clc1cc(N2C[C@@H]3CN[C@@H]3C2)cnc1Cl.O=C(O)/C=C\C(=O)O,,C1CCOC1,CO,N,O,val
US20040266826A1,CCOC(CSc1cccc(F)c1)OCC>>Fc1ccc2ccsc2c1,,Clc1ccccc1,,,,val
US04851406,CC(=O)Cc1ccccc1.NNc1ccc(C2=NNC(=O)CC2)cc1>>Cc1[nH]c2ccc(C3=NNC(=O)CC3)cc2c1-c1ccccc1,,CCO,,Cl,Cl,val
US04826866,CCO.CCOC(=O)C(Cl)C(C)=O.CN(C(=S)NN)C1CCCC1>>CC(C)OC(C)C.CCC(C)=O,,CCO,,Cl,,val
US20070003680A1,CC(C)CNC(=O)C(C)(C)c1ccc(-c2ccccc2C=O)cc1>>CC(C)CNC(=O)C(C)(C)c1ccc(-c2ccccc2CO)cc1,,CO,,[BH4-].[Na+],,val
US04132746,COC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C.NN>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NN,,CO,,,,val
US20120316200A1,CO.O=C(O)c1ccc2cc(Br)ccc2n1>>COC(=O)c1ccc2cc(Br)ccc2n1,,Cl,,,,val
US20040143001A1,CCCCCCCCBr.Oc1ccc(-c2c3nc(c(-c4ccc(O)cc4)c4ccc([nH]4)c(-c4ccc(O)cc4)c4nc(c(-c5ccc(O)cc5)c5ccc2[nH]5)C=C4)C=C3)cc1>>CCCCCCCCOc1ccc(-c2c3nc(c(-c4ccc(O)cc4)c4ccc([nH]4)c(-c4ccc(O)cc4)c4nc(c(-c5ccc(O)cc5)c5ccc2[nH]5)C=C4)C=C3)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110144105A1,CCO.COCCS(=O)(=O)c1ccc(C(=CC2CCOCC2)c2cc3cc(F)cnc3n2S(=O)(=O)c2ccccc2)cc1>>CCOCCS(=O)(=O)c1ccc(C(=CC2CCOCC2)c2cc3cc(F)cnc3[nH]2)cc1,,C1CCOC1,ClCCl,[Na+].[OH-],,val
US05063228,CN1CC(CCCl)c2nc3ccccc3n2C1=O.c1ccc(N2CCNCC2)cc1>>CN1CC(CCN2CCN(c3ccccc3)CC2)c2nc3ccccc3n2C1=O,,Cc1ccccc1,,,,val
US04743601,Clc1ccc2c(Cl)ccnc2c1.NCC1(O)CCCCC1>>OC1(CNc2ccnc3cc(Cl)ccc23)CCCCC1,,CCOCCO,,CCN(CC)CC,Cl,val
US05891909,COc1cc(CCCC2OCCCO2)cc(OS(=O)(=O)c2ccccc2Cl)c1>>COc1cc(CCCC=O)cc(OS(=O)(=O)c2ccccc2Cl)c1,,C1CCOC1,O,Cl,,val
US20120208797A1,C=O.Cn1c(OC2CCN(c3ccc(CN4CCNCC4)cc3)CC2)nc(-c2ccncn2)cc1=O>>CN1CCN(Cc2ccc(N3CCC(Oc4nc(-c5ccncn5)cc(=O)n4C)CC3)cc2)CC1,CC(=O)O,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090156604A1,COC(=O)c1ccc(-c2nc3sccn3c2-c2ccccc2)cc1>>OCc1ccc(-c2nc3sccn3c2-c2ccccc2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110213062A1,CCCCOP(=O)(CC)C(CC=O)c1ccccc1>>CCP(=O)(O)C(CCO)c1ccccc1,,CCCCO,O,,,val
US03958006,CN=C=O.O=CNc1ccc(O)c2c1CCCC2>>CNC(=O)Oc1ccc(NC=O)c2c1CCCC2,CCN(CC)CC,CC(C)=O,,,,val
US20130072467A1,C#CCNC1=NC(=O)S/C1=C\C1CCN(Cc2ccccc2)CC1.O=C(O)/C=C/C(=O)O>>C#CCNC1=NC(=O)S/C1=C\C1CCN(Cc2ccccc2)CC1.O=C(O)/C=C/C(=O)O,,CCO,,,,val
US20070105890A1,CC(C)(C)OC(=O)c1cc([N+](=O)[O-])ccc1F>>CC(C)(C)OC(=O)c1cc(N)ccc1F,[Pd],C1CCOC1,,O,,val
US20150344466A1,C[Si](C)(C)C#Cc1c(C(=O)NCC2CCOC2)noc1COCc1ccccc1F>>C#Cc1c(C(=O)NCC2CCOC2)noc1COCc1ccccc1F,,CO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20110311474A1,COS(=O)(=O)C(F)(F)F.O=S(=O)(N1CC(F)(F)C1)n1ccnc1>>C[n+]1ccn(S(=O)(=O)N2CC(F)(F)C2)c1.O=S(=O)([O-])C(F)(F)F,,ClCCl,,,,val
US20150111870A1,COc1nc2ccc(Br)cc2c(Cl)c1CN1CCC(C(F)(F)F)CC1.Cn1nncc1C(=O)C1CN(C(=O)OC(C)(C)C)C1>>COc1nc2ccc(C(O)(c3cnnn3C)C3CN(C(=O)OC(C)(C)C)C3)cc2c(Cl)c1CN1CCC(C(F)(F)F)CC1,,C1CCOC1,,[Li]CCCC,,val
US20060211720A1,CCc1cc(O[Si](C)(C)C(C)(C)C)c(F)c(N(Cc2nc(-c3ccccc3)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c2ccc(C#N)cc2)c1>>CCc1cc(O)c(F)c(N(Cc2nc(-c3ccccc3)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c2ccc(C#N)cc2)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080076771A1,COC(=O)c1ccc(Nc2cc(Cl)ncn2)cc1>>COC(=O)c1ccc(Nc2ccncn2)cc1,[Pd],CO,,,,val
US20100209378A1,CC(O)C1CCCC(C)(C)C1.O=C(O)CCl>>CC(OCC(=O)O)C1CCCC(C)(C)C1,,Cc1ccccc1,,Cl,[H-].[Na+],val
US20120094993A1,Nc1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1.O=C(O)C1CCOC1>>O=C(Nc1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1)C1CCOC1,,CO,,,,val
US20110245310A1,CC(C)c1nc2c(n1Cc1ccc(Cl)cc1)C(=O)CCC2>>CC(C)c1nc2c(n1Cc1ccc(Cl)cc1)C(O)CCC2,,CO,ClCCl,[BH4-].[Na+],,val
US20140187556A1,CC(O)c1cccc(-c2ccc(OC(F)F)c(N)c2)c1.O=Cc1ccccc1>>CC(O)c1cccc(-c2ccc(OC(F)F)c(NCc3ccccc3)c2)c1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140350019A1,Cc1cc(-c2cccc(F)c2)cc(C(=O)Nc2c(F)ccc(O)c2F)c1F>>Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(O)c2F)c1F,,C1CCOC1,,,,val
US20120225844A1,O=C1CCC(=O)N1Cl.O=C1NCCn2nc(COc3ccccc3)cc21>>O=C1NCCn2nc(COc3ccc(Cl)cc3)cc21,,ClC(Cl)Cl,,,,val
US20070142357A1,CC1CN(C(=O)C(F)(F)F)CCc2ccc(Cl)c(F)c21>>CC1CNCCc2ccc(Cl)c(F)c21,,CO,,[Na+].[OH-],,val
US20150376181A1,CC1(c2cccc(F)c2)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21.COc1ccc(COc2cc(C)c3n(c2=O)C2(CCCCC2)NC3=O)cc1>>Cc1cc(C(=O)c2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1,,C1CCOC1,,[Li]CCCC,,val
US20100227859A1,COC(=O)[C@@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3noc(C)n3)cc12)C(C)C>>Cc1nc(-c2ccc3oc4cc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)ccc4c3c2)no1,,CC(=O)O,Cl,O,,val
US20100331335A1,CCCC[Sn](CCCC)(CCCC)c1ncco1.O=[N+]([O-])c1scc(Br)c1Br>>O=[N+]([O-])c1scc(Br)c1-c1ncco1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20110152245A1,COc1ccc(CN2CCC(c3ccc([N+](=O)[O-])cn3)C2)cc1>>COc1ccc(CN2CCC(c3ccc(N)cn3)C2)cc1,[Pd],CO,,,,val
US20020099212A1,CN(C)C=O.Cc1nc2ccc(Br)nc2n1Cc1ccc(C(=O)O)cc1Cl.ClCCl.O=C(Cl)C(=O)Cl>>Cc1nc2ccc(Br)nc2n1Cc1ccc(C(=O)OC2CCCCC2)cc1Cl,,ClCCl,,,,val
US20120101086A1,Cc1c2c(nn1-c1nnc(-c3ccc(OC(C)C)c(C#N)c3)s1)CCNC2.OCCBr>>Cc1c2c(nn1-c1nnc(-c3ccc(OC(C)C)c(C#N)c3)s1)CCN(CCO)C2,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150175557A1,CC(F)(F)COc1ncncc1CN.C[C@@]1(O)CCC[C@H](Nc2nc(S(C)(=O)=O)ncc2C#N)C1>>CC(F)(F)COc1ncncc1CNc1ncc(C#N)c(N[C@H]2CCC[C@@](C)(O)C2)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080176947A1,O=C(Cl)C(=O)Cl.O=C(O)C1CC12CCOCC2>>O=C(Cl)C1CC12CCOCC2,CN(C)C=O,ClCCl,,,,val
US20020187994A1,Brc1cnc2c(c1)CC1(CN3CCC1CC3)O2.OB(O)c1ccccc1>>c1ccc(-c2cnc3c(c2)CC2(CN4CCC2CC4)O3)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20110142916A1,CC(C)(C)C(=O)Cl.OCCCCCCCCCCBr>>CC(C)(C)C(=O)OCCCCCCCCCCBr,CN(C)c1ccncc1,c1ccncc1,,,,val
US20120046461A1,C#CCBr.COC(=O)c1ccc(O)c(OC)c1>>C#CCOc1ccc(C(=O)OC)cc1OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20070213323A1,O=c1cc(OCc2cccc(F)c2)ccn1Cc1cccc(F)c1>>O=c1cc(O)ccn1Cc1cccc(F)c1,[Pd],CO,,,,val
US20100324028A1,COc1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)cc(C(=O)N2CCc3cc(F)ccc32)n1>>O=C(c1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)cc(=O)[nH]1)N1CCc2cc(F)ccc21,,CN(C)C=O,,Cl,c1ccncc1,val
US04426385,CC1(C)Cc2cccc(O)c2O1.O=[N+]([O-])c1ccc(Cl)c(Cl)c1>>CC1(C)Cc2cccc(Oc3ccc([N+](=O)[O-])cc3Cl)c2O1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04873262,CCCN(CCC)C1CCc2cccc(CN)c2C1.CN=C=O>>CCCN(CCC)C1CCc2cccc(CNC(=O)NC)c2C1,,Cc1ccccc1,,,,val
US20060020146A1,COc1cc(C(=O)O)cc(OC)c1OC(C)=O.O=S(Cl)Cl>>COc1cc(C(=O)Cl)cc(OC)c1OC(C)=O,,COCCOC,,,,val
US06169188A,CC(C)(C)CI.CC1(C)OC(=O)C(O)=C1c1ccc(S(C)(=O)=O)cc1>>CC(C)(C)COC1=C(c2ccc(S(C)(=O)=O)cc2)C(C)(C)OC1=O,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20130065914A1,CN[C@@H]1CC[C@@H](Oc2ncccc2Nc2ncnc3sc(Cl)c(C)c23)CC1.CS(=O)(=O)Cl>>Cc1c(Cl)sc2ncnc(Nc3cccnc3O[C@@H]3CC[C@@H](N(C)S(C)(=O)=O)CC3)c12,,ClCCl,O,CCN(CC)CC,,val
US04294960,C=[N+]=[N-].O=C(CBr)C(=NO)C(=O)NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=CCS[C@H]12>>CON=C(C(=O)CBr)C(=O)NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=CCS[C@H]12,,C1CCOC1,CCOCC,,,val
US20070078120A1,COc1cccc(C2(CN)CCN(c3ccccc3OC)CC2)c1.O=Cc1ccccc1>>COc1cccc(C2(CNCc3ccccc3)CCN(c3ccccc3OC)CC2)c1,,CC(Cl)Cl,,CC(=O)O,O=C([O-])O.[Na+],val
US20110017986A1,C=CCc1ccc(-c2cccs2)s1.Cl[SiH](Cl)Cl>>Cl[Si](Cl)(Cl)CCCc1ccc(-c2cccs2)s1,[Pt],Cc1ccccc1,,,,val
US05753664,CI.O=C(c1ccc(Cl)cc1)c1ccc(Cn2ccc3c(Cl)n[nH]c(=O)c32)cc1>>Cn1nc(Cl)c2ccn(Cc3ccc(C(=O)c4ccc(Cl)cc4)cc3)c2c1=O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090221555A1,COc1cc2c(cc1N)CCN(C[C@H](O)C(F)(F)F)CC2.NC(=O)[C@H]1[C@@H]2C=C[C@@H](C2)[C@H]1Nc1nc(Cl)ncc1Cl>>COc1cc2c(cc1Nc1ncc(Cl)c(N[C@@H]3[C@H]4C=C[C@H](C4)[C@@H]3C(N)=O)n1)CCN(C[C@H](O)C(F)(F)F)CC2,,COCCO,,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US20150099777A1,CCI.COC(=O)c1ccc(I)cc1O>>CCOc1cc(I)ccc1C(=O)OC,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20080280877A1,COc1ccc2cc(OCC3(C(N)=O)CN(C(=O)c4ccc(F)cc4)C3)ccc2c1.CS(=O)(=O)Cl>>COc1ccc2cc(OCC3(C(=O)NS(C)(=O)=O)CN(C(=O)c4ccc(F)cc4)C3)ccc2c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20070185160A1,Nc1ccc2cc(-c3ccccc3C(F)(F)F)[nH]c(=O)c2c1.OC1COC(O)CO1>>O=c1[nH]c(-c2ccccc2C(F)(F)F)cc2ccc(NCCO)cc12,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20050043315A1,CC(C)n1nc(-c2c(-c3ccccc3)nc(N)nc2S(C)(=O)=O)ccc1=O.OCc1ccccn1>>CC(C)n1nc(-c2c(OCc3ccccn3)nc(N)nc2-c2ccccc2)ccc1=O,,CC(=O)N(C)C,,O,[H-].[Na+],val
US05736534,COc1cc2ncnc(Cl)c2cc1OC.Cc1c(O)cc2c(c1C)NCC2.Cl>>COc1cc2ncnc(N3CCc4cc(O)c(C)c(C)c43)c2cc1OC.Cl,,CN1CCCC1=O,,,,val
US20090124596A1,NC1CCC(NC(=O)c2cn3cc(F)ccc3n2)CC1.O=C(O)c1cc(F)cnc1NCCc1ccccc1>>O=C(N[C@@H]1CC[C@H](NC(=O)c2cc(F)cnc2NCCc2ccccc2)CC1)c1cn2cc(F)ccc2n1,,CC#N,,,,val
US20040106606A1,CC(C)C1(CCc2ccccc2CO)CC(O)=CC(=O)O1.Cc1ccc(S(=O)(=O)Sc2sc3ccccc3c2C(C)(C)C)cc1>>CC(C)C1(CCc2ccccc2CO)CC(O)=C(Sc2sc3ccccc3c2C(C)(C)C)C(=O)O1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090124596A1,NC1CCC(n2c(=O)c3cc(F)cnc3n(Cc3ccc(F)cc3)c2=O)CC1.O=C(O)c1cn2ccccc2n1>>O=C(NC1CCC(n2c(=O)c3cc(F)cnc3n(Cc3ccc(F)cc3)c2=O)CC1)c1cn2ccccc2n1,,ClC(Cl)Cl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100029686A1,C=CC(=O)OCC.COC(=O)CNC(=O)OC(C)(C)C>>CCOC(=O)C1CN(C(=O)OC(C)(C)C)CC1=O,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20060063841A1,CC(C)(C)OCl.O=[N+]([O-])c1ccc(Cl)cc1C=NO>>O=[N+]([O-])c1ccc(Cl)cc1C(Cl)=NO,,ClCCCl,,,,val
US20150140493A1,C=COCCCl.COc1ccc(C(=O)c2ccc(O)cc2)c(OC)c1>>C=COCCOc1ccc(C(=O)c2ccc(OC)cc2OC)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040058941A1,CCOC(=N)/C=C/c1ccc(F)cc1.Cl.N>>Cl.N=C(N)/C=C/c1ccc(F)cc1,,CO,,,,val
US20080090840A1,O=C(C[C@@H](c1ccc(OCCOc2ccc(C(F)(F)F)cc2)cc1)c1ccon1)N1C(=O)OC[C@@H]1Cc1ccccc1.OO>>O=C(O)C[C@@H](c1ccc(OCCOc2ccc(C(F)(F)F)cc2)cc1)c1ccon1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20130237501A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3cccc(Br)c3)S(C)(=O)=O)c(C3CC3)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3cccc(B4OC(C)(C)C(C)(C)O4)c3)S(C)(=O)=O)c(C3CC3)cc12,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20130023541A1,CCNCc1ccc(CN2CCN(c3ncccc3C(=O)OC(C)C)CC2)cc1.O=Cc1c(F)cccc1F>>CCN(Cc1ccc(CN2CCN(c3ncccc3C(=O)OC(C)C)CC2)cc1)Cc1c(F)cccc1F,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20090270359A1,CN.Cc1nn(Cc2ccc(C(=O)Cl)cc2)c(C)c1-c1ccc(C#N)c(Cl)c1>>CNC(=O)c1ccc(Cn2nc(C)c(-c3ccc(C#N)c(Cl)c3)c2C)cc1,,C1CCOC1,,O,,val
US05308857,COC(=O)c1ccc(-c2csc(N=C(N)N)n2)o1.NN>>NNC(=O)c1ccc(-c2csc(N=C(N)N)n2)o1,,CCO,,O,,val
US20070276138A1,BrC(Br)(Br)Br.COC(=O)C(Cc1cccc(C#CCCCO)c1)OC>>COC(=O)C(Cc1cccc(C#CCCCBr)c1)OC,,ClCCl,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06649643B1,CC[C@](O)(c1ccc2cc(C(=O)NC)ccc2c1)c1c[nH]cn1.O=C(O)/C=C/C(=O)O>>CC[C@](O)(c1ccc2cc(C(=O)NC)ccc2c1)c1c[nH]cn1.O=C(O)/C=C/C(=O)O,,CCO,,,,val
US06586431B1,Brc1ccc(Br)nc1.COc1cccc(CC#N)c1>>COc1cccc(C(C#N)c2ccc(Br)cn2)c1,,CCOCC,CN(C)C=O,CCCCCC,[H-].[Na+],val
US20150353553A1,Cc1cccc(Br)n1.O=C(OO)c1cccc(Cl)c1>>Cc1cccc(Br)[n+]1[O-],,ClCCl,ClCCl,,,val
US05880147,CCOC(=O)/C=C/c1ccc(C(C)(C)C)c([N+](=O)[O-])c1>>CC(C)(C)c1ccc(/C=C/CO)cc1[N+](=O)[O-],,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US04746352,BrBr.Cc1cc(=O)n(-c2cc(C(=O)OC(C)C)c(Cl)cc2F)c(=O)[nH]1>>Cc1[nH]c(=O)n(-c2cc(C(=O)OC(C)C)c(Cl)cc2F)c(=O)c1Br,,CC(=O)O,,,,val
US20130172384A1,O=C(NC[C@@H]1CCN(C(=O)C2CC2)C1)NNC(=O)c1ccc(Br)cc1F>>O=C(C1CC1)N1CC[C@@H](Cn2c(-c3ccc(Br)cc3F)n[nH]c2=O)C1,,O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20040043146A1,CCCCCCCCCCCCCCCCC1CC(=O)OC1=O.NO>>CCCCCCCCCCCCCCCC(CC(=O)NO)C(=O)O,,CC#N,,Cl,c1ccncc1,val
US05538987,CC(N)=S.CCOC(=O)C(Br)C(=O)c1ccc(C)cc1>>CCOC(=O)c1sc(C)nc1-c1ccc(C)cc1,,CCO,,,,val
US20100216788A1,CS(=O)(=O)c1cccc(Oc2ccc(N)cc2Cl)c1.O=C(OCCOCCn1ccc2ncnc(Cl)c21)c1ccccc1>>CS(=O)(=O)c1cccc(Oc2ccc(Nc3ncnc4ccn(CCOCCO)c34)cc2Cl)c1,,CC(C)O,,[Na+].[OH-],,val
US20140018533A1,CCOC(=O)C1=C(Nc2cccc(Cl)c2)OC(=Cc2c[nH]c3ncccc23)C1=O>>O=C1C=C(Nc2cccc(Cl)c2)OC1=Cc1c[nH]c2ncccc12,,CN(C)C=O,,,,val
US05378844,CCCn1c(=O)c2[nH]c(C3(N)CCCC3)nc2n(CCC)c1=O.CCOC(C)=O>>CCCn1c(=O)c2[nH]c(C3(NC(=O)OCC)CCCC3)nc2n(CCC)c1=O,,C1CCOC1,,Cl,c1ccncc1,val
US20050250822A1,Cc1cc(C(=O)C(F)(F)F)ccc1NC(=O)OC(C)(C)C.OC(CCl)c1ccc(Cl)cc1>>Cc1cc(C2(C(F)(F)F)OCC(c3ccc(Cl)cc3)O2)ccc1NC(=O)OC(C)(C)C,,O,,CS(C)=O,[H-].[Na+],val
US20100068301A1,CCOC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCc3ccc(C)cn3)ccc2n1Cc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.OCc1ccc(Cl)nc1>>CCOC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCc3ccc(C)cn3)ccc2n1Cc1ccc(-c2ccc(CO)cn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,O=C([O-])[O-].[K+].[K+],,val
US04894451,COc1ccc(OC)c2c1C(=O)c1ccccc1C2=O.NCCCN>>COc1ccc(NCCCN)c2c1C(=O)c1ccccc1C2=O,,ClCCl,,,,val
US03931180,CCCOS(=O)(=O)c1ccc(C)cc1.CN(C)c1nc(O)cc(O)n1>>CCCOc1cc(O)nc(N(C)C)n1,,CC(=O)O,,[Na+].[OH-],,val
US05391552,NCCc1ccccc1.c1ccc(C(c2ccccc2)N2CCN(CC3CO3)CC2)cc1>>OC(CNCCc1ccccc1)CN1CCN(C(c2ccccc2)c2ccccc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120172345A1,CC1(C)OC(=O)CC(=O)O1.O=C(Cl)Cc1ccc(Cl)cc1>>CC1(C)OC(=O)C(=C(O)Cc2ccc(Cl)cc2)C(=O)O1,,ClCCl,,Cl,c1ccncc1,val
US20100286175A1,Cc1cccnc1-c1ccccc1.O=C(OO)c1cccc(Cl)c1>>Cc1ccc[n+]([O-])c1-c1ccccc1,,ClCCl,,,,val
US04123529,O=[N+]([O-])c1ccc(N2CCN(Cc3ncc(-c4ccccc4)o3)CC2)cc1>>Nc1ccc(N2CCN(Cc3ncc(-c4ccccc4)o3)CC2)cc1,[Pd],CC(=O)O,,[H][H],,val
US20110263544A1,Fc1cccc(OC(F)(F)F)c1.O=[N+]([O-])O>>O=[N+]([O-])c1ccc(F)cc1OC(F)(F)F,,O=S(=O)(O)O,,,,val
US04499088,CC(C)(C)OC(=O)CON=C(C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CCl)CS(=O)[C@H]12)c1cscn1.Cc1ccc(S)nn1>>Cc1ccc(SCC2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)C(NC(=O)C(=NOCC(=O)OC(C)(C)C)c4cscn4)[C@H]3S(=O)C2)nn1,,CN(C)C=O,O,CCN(CC)CC,CCOC(C)=O,val
US20120108583A1,CC(F)(F)c1cccc(N)c1.CC1(C)Cc2c(c(C(=O)O)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1>>CC1(C)Cc2c(c(C(=O)Nc3cccc(C(C)(F)F)c3)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1,,C1CCOC1,,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US20160176916A1,CC(C)(C)OC(=O)NCCCOCCOCCOCCCNC(=O)CCl.COC(=O)c1cccc(O)c1C(=O)OC>>COC(=O)c1cccc(OCC(=O)NCCCOCCOCCOCCCNC(=O)OC(C)(C)C)c1C(=O)OC,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120088748A1,CC1(C)OCC(C(CNCc2ccccc2)c2ccc(Cl)c(Cl)c2)O1>>OCC(O)C(CNCc1ccccc1)c1ccc(Cl)c(Cl)c1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20090018150A1,CC(=O)Nc1nc(-c2cccc3ccc(Br)cc23)c[nH]1>>Nc1nc(-c2cccc3ccc(Br)cc23)c[nH]1,,Cl,,,,val
US04132796,C1CO1.O=S(c1ccc2c(c1)C(=C1CCNCC1)c1ccccc1C=C2)C(F)(F)F>>CC(O)N1CCC(=C2c3ccccc3C=Cc3ccc(S(=O)C(F)(F)F)cc32)CC1,,CO,ClC(Cl)Cl,O=C=O,,val
US06124280,CC(CCC(=O)N(Cc1ccccc1)Cc1ccccc1)(c1ccc(O)cc1)c1ccc(O)cc1>>CC(CCCN(Cc1ccccc1)Cc1ccccc1)(c1ccc(O)cc1)c1ccc(O)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100136136A1,Cc1ccc(Cl)cc1NC(=O)c1nc[nH]c1C(=O)Nc1nc2cc(OC3CCNCC3)ccc2[nH]1>>Cc1ccc(Cl)cc1NC(=O)c1nc[nH]c1C(=O)Nc1nc2cc(OC3CCNCC3)ccc2[nH]1,,C1COCCO1,,Cl,Cl,val
US04299831,O=C(O)c1c(C(F)(F)F)nc2cc(C(F)(F)F)ccc2c1O.O=S(Cl)Cl>>O=C(Cl)c1c(C(F)(F)F)nc2cc(C(F)(F)F)ccc2c1O,,c1ccccc1,,,,val
US09096550B2,C=C1C[C@H](/C=C/C(C)(C)[C@]2(OC)O[C@H](C[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](C)OCOCc3ccccc3)C/C(=C\C(=O)OC)[C@@H]2OC(=O)CCCCCCC)O[C@H](C[C@H]2C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H](C[C@H](CC(=O)O)OCc3ccc(OC)cc3)O2)C1>>C=C1C[C@H](/C=C/C(C)(C)[C@]2(OC)O[C@H](C[C@@H](O)[C@@H](C)OCOCc3ccccc3)C/C(=C\C(=O)OC)[C@@H]2OC(=O)CCCCCCC)O[C@H](C[C@H]2C[C@@H](O)C[C@@H](C[C@H](CC(=O)O)OCc3ccc(OC)cc3)O2)C1,,C1CCOC1,c1ccncc1,,,val
US20090186879A1,O=[N+]([O-])c1cc(F)cc([N+](=O)[O-])c1NCCCO>>Nc1cc(F)cc(N)c1NCCCO,[Pd],C1CCOC1,,,,val
US20070078136A1,Cc1c(Cl)nn2ccnc2c1Nc1cccc(O)c1.N[C@H]1CC[C@H](N)CC1>>Cc1c(N[C@@H]2CC[C@@H](N)CC2)nn2ccnc2c1Nc1cccc(O)c1,,CO,O,,,val
US20080153852A1,Clc1cc(Cl)ncn1.OC(c1ccccc1-c1ccoc1)C(F)(F)F>>FC(F)(F)C(Oc1cc(Cl)ncn1)c1ccccc1-c1ccoc1,,C1CCOC1,,O,[H-].[Na+],val
US20110190269A1,CN(C)/C=C/C(=O)c1ccncc1.COc1cc(Nc2nnc(N)[nH]2)ccc1-n1cnc(C)c1>>COc1cc(Nc2nc3nccc(-c4ccncc4)n3n2)ccc1-n1cnc(C)c1,,CC(=O)O,,,,val
US04556711,Cc1nccnc1Cl.O.O=C(OCc1ccccc1)N(O)c1ccccc1>>Cc1nc(-c2ccc(NC(=O)OCc3ccccc3)cc2)c[nH]c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20130018034A1,COC(=O)c1ccc(N2CC(CC#N)(n3cc(-c4ncnc5c4ccn5COCC[Si](C)(C)C)cn3)C2)c(F)c1>>C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CN(c5ccc(C(=O)O)cc5F)C4)c3)ncnc21,,CO,O,Cl,[Li+].[OH-],val
US20090182140A1,CCOC(=O)C1(CCN2CCCC2)CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3sccc3n2)CC1>>O=C(O)C1(CCN2CCCC2)CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3sccc3n2)CC1,,CCO,,Cl,[Na+].[OH-],val
US20150299120A1,CNC1(C#N)CCCC1OCOC.C[N+]1([O-])CCOCC1.C[Si](C)(C)C#N>>COCOC1CCCC1(C#N)O[Si](C)(C)C,,ClCCl,O,,,val
US20100130446A1,C=C[Mg]Br.CON(C)C(=O)C(CC1CCCC1)c1ccc(SC)cn1>>C=CC(=O)C(CC1CCCC1)c1ccc(SC)cn1,,C1CCOC1,,Cl,,val
US20050059729A1,CCOC(=O)CCN(C)c1ccc2cccc(CCNC(=O)Cc3ccccc3)c2c1>>CN(CCC(=O)O)c1ccc2cccc(CCNC(=O)Cc3ccccc3)c2c1,,CO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20050267095A1,BrCCCBr.N#CC1(c2ccc(O)cc2)CCCCC1>>N#CC1(c2ccc(OCCCBr)cc2)CCCCC1,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060229294A1,COc1ccc(-c2ccc(C=O)cc2)cc1.NCCCNc1nsc2ccc(Br)cc12>>COc1ccc(-c2ccc(CNCCCNc3nsc4ccc(Br)cc34)cc2)cc1,CC(=O)O,CCOC(C)=O,ClCCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05580751,COc1ccc(CNC(=O)c2ccccc2)c(OC)c1>>O=C(NCc1ccccc1)c1ccccc1,,O=C(O)C(F)(F)F,,,,val
US05571775,CO.COc1cc(Cl)cc2nc(S(=O)(=O)Nc3c(Cl)cccc3Cl)nn12>>COc1cc(OC)n2nc(S(=O)(=O)Nc3c(Cl)cccc3Cl)nc2c1,,CS(C)=O,ClCCl,CC(=O)O,C[O-].[Na+],val
US20140221387A1,Cc1ccc(B(O)O)o1.O=C(Nc1cccnc1)c1cc(Cl)nc2ccc(-c3ccccc3)cc12>>Cc1ccc(-c2cc(C(=O)Nc3cccnc3)c3cc(-c4ccccc4)ccc3n2)o1,,C1COCCO1,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US20070015234A1,O=C(O)c1ccc(-c2ccccc2)cc1.O=C(OI(OC(=O)C(F)(F)F)c1ccccc1)C(F)(F)F>>O=C(O)c1ccc(-c2ccc(I)cc2)cc1,,ClC(Cl)(Cl)Cl,,,,val
US20020147188A1,CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NC1CCCN(C(=O)OCc2ccccc2)CC1O>>CC(C)C[C@H](N)C(=O)NC1CCCN(C(=O)OCc2ccccc2)CC1O,,C1COCCO1,CO,Cl,,val
US20120295884A1,COCCN(C)Cc1cc(Cl)c(F)c(CNC(=O)OC(C)(C)C)c1>>COCCN(C)Cc1cc(Cl)c(F)c(CN)c1,,C1COCCO1,,Cl,,val
US20100087434A1,CC(C)(C)OC(=O)N1CCC(COCc2cc(-c3nnn[nH]3)cc(C(F)(F)F)c2)(c2ccccc2)CC1.Cn1nnc(-c2cc(COCC3(c4ccccc4)CCN(C(=O)OC(C)(C)C)CC3)cc(C(F)(F)F)c2)n1.O=C([O-])N1CCC(c2ccccc2)CC1>>Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCN(C(=O)OC(C)(C)C)CC2)cc(C(F)(F)F)c1.O=C([O-])N1CCC(c2ccccc2)CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160272628A1,CCc1cc(Br)ccc1S(=O)(=O)NC1CNC(=O)C1.O=C1CCC(=O)N1Br>>CC(Br)c1cc(Br)ccc1S(=O)(=O)NC1CNC(=O)C1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20090318385A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNc1ccc(C=O)c2cc(C(F)(F)F)nn12>>CN(C(=O)OC(C)(C)C)c1ccc(C=O)c2cc(C(F)(F)F)nn12,CN(C)c1ccccn1,CC#N,O,,,val
US20130196974A1,C#C[Sn](CCCC)(CCCC)CCCC.O=S1(=O)CCN(c2cc(Cl)c3cc(OC(F)(F)F)ccc3n2)Cc2ccccc21>>C#Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(Cl)c2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US04230703,CCOC(=O)Cc1ccc2c(c1)C(=O)c1ccccc1CN2>>O=C(O)Cc1ccc2c(c1)C(=O)c1ccccc1CN2,,O,,CO,,val
US20050059713A1,COC(=O)c1cnc(C)cn1.O=C1CCC(=O)N1Br>>COC(=O)c1cnc(CBr)cn1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20090137595A1,CC(C)(C#N)c1cccc(C(=O)O)c1.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c(Cl)cc1F>>CC(C)(C#N)c1cccc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c(Cl)cc2F)c1,CN(C)C=O,CN1CCCC1=O,,C1CCOC1,O=C(Cl)C(=O)Cl,val
US20070027133A1,CCCCC([Sn])=C(CCCC)CCCC.CCOC(=O)c1nn(-c2ccccc2Cl)c(-c2ccc(Cl)cc2)c1Br.CN(C)C=O>>C=Cc1c(C(=O)OCC)nn(-c2ccccc2Cl)c1-c1ccc(Cl)cc1,,CN(C)C=O,,,,val
US20090105212A1,CCCCOc1nc(N)c2nc(OC)n(Cc3ccc(OCCCl)nc3)c2n1.COC(=O)C1CCNCC1>>CCCCOc1nc(N)c2nc(OC)n(Cc3ccc(OCCN4CCC(C(=O)OC)CC4)nc3)c2n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080269208A1,CCOC(=O)C(Br)C(=O)OCC.O=C(NC[C@@H]1CCCN1)OCc1ccccc1>>CCOC(=O)C(C(=O)OCC)N1CCC[C@H]1CNC(=O)OCc1ccccc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US03980681,CC(=O)Oc1ccc2c(c1)CC[C@H]1[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@H]21.CS(=O)(=O)Cl>>CC(=O)Oc1ccc2c(c1)CC[C@H]1[C@@H]3CC[C@H](OS(C)(=O)=O)[C@@]3(C)CC[C@H]21,,O,c1ccncc1,,,val
US04873248,CO.Cc1cccc(C#N)n1>>COC(=N)c1cccc(C)n1,,CO,,CC(=O)O,C[O-].[Na+],val
US20070066820A1,CCOC(=O)c1ccc(Oc2ccc(I)cc2)cc1.OB(O)c1ccsc1>>CCOC(=O)c1ccc(Oc2ccc(-c3ccsc3)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20130338159A1,CC(C)C(N)O.CSc1ncc(-c2ccnc(Nc3ccc(C#N)cc3)n2)c(C(C)C)n1>>CC(C)c1nc(NCC(C)(C)O)ncc1-c1ccnc(Nc2ccc(C#N)cc2)n1,,CN1CCCC1=O,,C1CCOC1,,val
US20040138065A1,FCCBr.N#CC(C#N)Cc1ccc(Br)cc1>>N#CC(C#N)(CCF)Cc1ccc(Br)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100009986A1,CNc1ccccc1N.O=C(O)CCc1c[nH]c2ccccc12>>Cn1c(CCc2c[nH]c3ccccc23)nc2ccccc21,,ClC(Cl)Cl,,,,val
US20140066659A1,O=S(=O)(C(CC(S(=O)(=O)C(F)(F)F)S(=O)(=O)C(F)(F)F)S(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1c(-c2ccccc2)cccc1-c1ccccc1>>O=S(=O)(C(Cc1ccc(-c2ccccc2)c(O)c1-c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F,,CC#N,,,,val
US20160016948A1,CO[C@H]1CCN(c2nccc(Nc3cc4c(cn3)c(-c3[nH]ncc3C)cn4C(C)C)n2)C[C@H]1F.OCCBr>>CO[C@H]1CCN(c2nccc(Nc3cc4c(cn3)c(-c3nn(CCO)cc3C)cn4C(C)C)n2)C[C@H]1F,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110130398A1,COc1cc([N+](=O)[O-])ccc1NC(=O)C1NC(CC(C)(C)C)C2(C(=O)Nc3cc(Cl)ccc32)C1c1cccc(Cl)c1F>>COc1cc(N)ccc1NC(=O)C1NC(CC(C)(C)C)C2(C(=O)Nc3cc(Cl)ccc32)C1c1cccc(Cl)c1F,[Zn],CO,,[Cl-].[NH4+],,val
US20080039459A1,CC(=O)SCc1cc2nc(C)nc(N3CCOCC3)c2s1.COCCCOS(=O)(=O)c1ccc(C)cc1>>COCCCSCc1cc2nc(C)nc(N3CCOCC3)c2s1,,CO,,C[O-].[Na+],,val
US05308854,CCCCc1cc([N+](=O)[O-])c(=O)[nH]c1C>>CCCCc1cc(N)c(=O)[nH]c1C,[Pd],C1CCOC1,CO,,,val
US20040059100A1,CC(=O)c1c(O)cccc1O.O=C(Cl)c1ccc(Cl)cc1>>O=c1cc(-c2ccc(Cl)cc2)oc2cccc(O)c12,,C1CCOC1,,Cl,[Li+].[OH-],val
US20090226398A1,CCCOc1ccc(B(O)O)c(C(F)(F)F)c1.OCc1ccc(Br)cn1>>CCCOc1ccc(-c2ccc(CO)nc2)c(C(F)(F)F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US04585768,CCC(=O)Cl.COc1ccc([C@@H]2Sc3cc(Cl)ccc3N(CCN(C)C(=O)OCc3ccccc3)C(=O)[C@@H]2O)cc1>>CCC(=O)O[C@H]1C(=O)N(CCN(C)C(=O)OCc2ccccc2)c2ccc(Cl)cc2S[C@H]1c1ccc(OC)cc1,,c1ccncc1,,,,val
US20120258946A1,COC(=O)C(C(=O)OC)c1ccc([N+](=O)[O-])cc1F>>COC(=O)Cc1ccc([N+](=O)[O-])cc1F,,CS(C)=O,O,[Cl-].[Na+],,val
US20130035318A1,C=C(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CC(C)(C)OC(=O)NC1(C(=O)O)CC1>>C=C(C)[C@@H]1CC[C@]2(NC(=O)C3(NC(=O)OC(C)(C)C)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090203657A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)O)n1.CN1CCC(Cc2cccc(-c3cccc(CN)c3)c2)CC1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2cccc(-c3cccc(CC4CCN(C)CC4)c3)c2)n1,,CS(C)=O,ClCCl,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04845097,CCN.Cc1cc(CCBr)ccc1OCCNc1ncnc(C)c1Cl>>CCNCCc1ccc(OCCNc2ncnc(C)c2Cl)c(C)c1,,CCO,,,,val
US20130336920A1,CC1(C)OB(c2cc(N3CCCCC3)ccc2[N+](=O)[O-])OC1(C)C.COC(=O)c1ccnc(Br)c1>>COC(=O)c1ccnc(-c2cc(N3CCCCC3)ccc2[N+](=O)[O-])c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20070232529A1,CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)OC(C)(C)C)C(=O)O.COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314>>CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)CN)C(=O)O.COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314,,C1COCCO1,,Cl,,val
US20070015774A1,COC(=O)[C@@H](N)C(C)C.ClCc1nc(Cl)c2ccccc2n1>>COC(=O)[C@@H](Nc1nc(CCl)nc2ccccc12)C(C)C,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120184542A1,CC(C)(C)OC(=O)NCCC(N)c1ccccc1.COc1ncc2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1>>COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CCNC(=O)OC(C)(C)C)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020143046A1,CCOC(=O)/C=C(/C)N.COC(=O)C(=Cc1ccccc1Cl)C(=O)COCCN1C(=O)c2ccccc2C1=O>>CCOC(=O)C1=C(C)NC(COCCN2C(=O)c3ccccc3C2=O)=C(C(=O)OC)C1c1ccccc1Cl,,CC(C)O,,,,val
US20110237573A1,CC(=O)N1CCN(c2ccc(NC(=O)Cc3cnc(Cl)c(F)c3)nc2)CC1.Cc1cc(B2OC(C)(C)C(C)(C)O2)ccn1>>CC(=O)N1CCN(c2ccc(NC(=O)Cc3cnc(-c4ccnc(C)c4)c(F)c3)nc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20090143372A1,CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(Br)cc23)CC1.COc1ccc(B2OC(C)(C)C(C)(C)O2)cc1C=O>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccc(OC)c(C=O)c4)cc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20110212918A1,COC(=O)Nc1cnc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(CN)c1>>NCc1cc(N)cnc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2,,CCO,O,Cl,[K+].[OH-],val
US20120309739A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3oc4nc(S(C)(=O)=O)nc(N5CCOCC5)c4c3-c3ccccc3)cc2)CCC1.NCCO>>CC(C)(C)OC(=O)NC1(c2ccc(-c3oc4nc(NCCO)nc(N5CCOCC5)c4c3-c3ccccc3)cc2)CCC1,,CN(C)C=O,Cc1ccccc1,,,val
US06218392B1,CCOC(=O)C1CCN(c2nnc(NCc3ccc(OC)c(Cl)c3)c3cc(Cl)ccc23)CC1>>COc1ccc(CNc2nnc(N3CCC(C(=O)O)CC3)c3ccc(Cl)cc23)cc1Cl,,C1CCOC1,,CO,[Na+].[OH-],val
US20110315933A1,Nc1ccc2ccccc2c1-c1cccc(C(=O)O)c1>>Nc1ccc2ccccc2c1-c1cccc(CO)c1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20100249093A1,C1CCNC1.CC[C@H]1CO1>>CC[C@H](O)CN1CCCC1,,O,,,,val
US20060217380A1,NCCN1CCOCC1.O=C(O)c1cc([N+](=O)[O-])cc(C(F)(F)F)c1>>O=C(NCCN1CCOCC1)c1cc([N+](=O)[O-])cc(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20140343278A1,ClCCl.Cn1c(=O)ccc2cc(OCCCCCNCCc3cccnc3)ccc21.O=S(=O)(Cl)c1ccccc1>>Cl.Cn1c(=O)ccc2cc(OCCCCCN(CCc3cccnc3)S(=O)(=O)c3ccccc3)ccc21,,ClCCl,O,CCN(CC)CC,,val
US20090186884A1,CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)[C@H]1CO1.N#Cc1ccc(CN)cc1>>CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)[C@H](O)CNCc1ccc(C#N)cc1,,CC#N,,,,val
US20120115850A1,CC(N)c1cc(Cl)cc(Cl)c1.O=[N+]([O-])c1ccc(F)cc1F>>CC(Nc1cc(F)ccc1[N+](=O)[O-])c1cc(Cl)cc(Cl)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20110207701A1,NS(=O)(=O)C1CC1.O=C(O)CCc1cccc2c1B(O)OC2>>O=C(CCc1cccc2c1B(O)OC2)NS(=O)(=O)C1CC1,,C1CCOC1,,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20140288326A1,C=CC(C)CCC(C(=C)C)C(C)=O.CC=O>>C=CC(C)CCC=C(C)CC(C)OC(C)=O,,ClCCCl,,CCOCC,FB(F)F,val
US20040242581A1,C1COCCN1.O=C(Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1)c1ccc(Cl)nc1>>O=C(Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1)c1ccc(N2CCOCC2)nc1,,CCOC(C)=O,CS(C)=O,,,val
US20100099680A1,CC(C)(C)OC(=O)Nc1cc(C(=O)CCC2CC2)cc(S(C)(=O)=O)c1.NN>>CC(C)(C)OC(=O)Nc1cc(-c2cc(C3CC3)[nH]n2)cc(S(C)(=O)=O)c1,,CCO,,O,,val
US20060058391A1,CCOC(=O)CCc1cccc(O)c1.O=S(=O)(Cl)Cl>>CCOC(=O)CCc1cc(O)ccc1Cl,,CCOCC,,,,val
US20100331306A1,CC(NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2c(Cl)c1-c1ccccn1.CNC>>CC(NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2c(N(C)C)c1-c1ccccn1,,C1CCOC1,CO,,,val
US20090012093A1,N#CCCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1.[N-]=[N+]=[N-]>>c1ccc(Oc2cccc(COc3ccc(CCc4nnn[nH]4)cc3)c2)cc1,,CCOC(C)=O,CN(C)C=O,[Cl-].[NH4+],,val
US20040092737A1,CCOC(=O)c1ccc2c(c1)Sc1nccnc1N2COC>>COCN1c2ccc(CO)cc2Sc2nccnc21,,CCOC(C)=O,ClCCl,CC(C)C[Al+]CC(C)C.[H-],,val
US20070254873A1,C=CS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)CC1.CN>>CNCCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)CC1,,CC#N,,,,val
US20040132727A1,CCN(CC)CCN.COc1cc2nccc(Oc3ccc(N)cc3C)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCN(CC)CCNC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(C)c1,,ClC(Cl)Cl,O,CCN(CC)CC,,val
US04184039,Nc1cc(Cl)ccc1S(N)(=O)=O.O=CC1CC=CCC1>>O=S1(=O)NC(C2=CCCCC2)Nc2cc(Cl)ccc21,,CC#N,,,,val
US04113968,CCOC(=O)CC(C)(C)C(Cl)C=C(Cl)Cl>>COC(=O)C1C(C=C(Cl)Cl)C1(C)C,,CO,,Cl,[Na],val
US20100256156A1,Cc1oc(Br)cc1C=O.OB(O)c1ccnc(Cl)c1>>Cc1oc(-c2ccnc(Cl)c2)cc1C=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20090124671A1,Clc1cccnc1Br.O=C1CCC2(CC1)OCCO2>>OC1(c2ncccc2Cl)CCC2(CC1)OCCO2,,CCOCC,,[Li]CCCC,,val
US04929269,CC(C)(C)N.COc1c([N+](=O)[O-])cc(C(C)(C)C)cc1S(=O)(=O)Cl>>COc1c([N+](=O)[O-])cc(C(C)(C)C)cc1S(=O)(=O)NC(C)(C)C,,CC#N,,,,val
US05280125,C[C@H]1NC(=O)O[C@H]1c1ccccc1.O=C(Cl)CCC(F)(F)F>>C[C@@H]1[C@H](c2ccccc2)OC(=O)N1C(=O)CCC(F)(F)F,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20100249146A1,CCOC(COc1cnc(Cl)c(Cl)c1)OCC.Oc1ccc2ncnc(Nc3cnccn3)c2c1>>CCOC(COc1cnc(Oc2ccc3ncnc(Nc4cnccn4)c3c2)c(Cl)c1)OCC,,CC(=O)N(C)C,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20110218201A1,COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.O=C(O)c1cc2ccccc2[nH]1>>COc1ccc(C2=NN(C3CCN(C(=O)c4cc5ccccc5[nH]4)CC3)C(=O)C2(C)C)cc1OC,,CN(C)C=O,,Cl,,val
US04284641,CCCCn1ccnc1.O=C(O)C(=O)O>>CCCCn1ccnc1.O=C(O)C(=O)O,,CO,,,,val
US20160023991A1,CCOC(=O)CCCCCOc1ccccc1CNC(C)C.O=C(O)c1ccc(Br)cc1>>CCOC(=O)CCCCCOc1ccccc1CN(C(=O)c1ccc(Br)cc1)C(C)C,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04277485,CSC(=C[N+](=O)[O-])NCCSCc1[nH]cnc1C.NCCSCn1nccn1>>Cc1nc[nH]c1CSCCNC(=C[N+](=O)[O-])NCCSCc1nccs1,,CC#N,,,,val
US04511568,CCCN.CCOC(=O)CBr>>CCCNCC(=O)OCC,,ClCCl,,,,val
US05196534,CN(N)c1ccccc1.O=C1CCNC(=O)C1>>CN(NC1=CC(=O)NCC1)c1ccccc1,,O,,,,val
US20070072928A1,Nc1ccccc1F.O=[N+]([O-])c1c(F)cccc1F>>O=[N+]([O-])c1c(F)cccc1Nc1ccccc1F,,CN(C)C=O,,[H-].[Na+],,val
US20120202785A1,BrCc1ccccc1.CC(C)(C)OC(=O)N[C@@H]1C[C@H](O)C1>>CC(C)(C)OC(=O)N[C@@H]1C[C@H](OCc2ccccc2)C1,,C1CCOC1,,[H-].[Na+],,val
US20100041713A1,COc1c(F)c(Cl)cc2c1CCCC2=O>>O=C1CCCc2c1cc(Cl)c(F)c2O,,Cc1ccccc1C,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100160315A1,Nn1c(N2CCCC2)nc2ccccc2c1=O.O=C(O)Cc1cc(F)cc(F)c1>>O=C(Cc1cc(F)cc(F)c1)Nn1c(N2CCCC2)nc2ccccc2c1=O,CN(C)C=O,CCOC(C)=O,ClCCl,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20120114739A1,CC(C)(C)OC(=O)C1CCC(c2cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3ncc(-c4cnc5ccccc5c4)c3n2)CN1C(=O)OC(C)(C)C.CO>>COC(=O)C1CCC(c2cc(N)n3ncc(-c4cnc5ccccc5c4)c3n2)CN1,,C1COCCO1,CO,Cl,,val
US05026707,COc1ccc(OC)c2c1CCC(O)C2>>COc1ccc(OC)c2c1CCC(=O)C2,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20130150339A1,CC(C)(O)c1ccccc1B(O)O.COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(Cl)nccc3c2)cc1>>CC(C)(O)c1ccccc1-c1nccc2cc(S(=O)(=O)Nc3nccs3)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20020019434A1,CCOC(=O)C(O)=CC(=O)c1c[nH]c2ccc(Cl)cc12.O=S(=O)(Cl)c1ccccc1>>CCOC(=O)C(O)=CC(=O)c1cn(S(=O)(=O)c2ccccc2)c2ccc(Cl)cc12,,C1CCOC1,,CN(C)C=O,[H-].[Na+],val
US20090306123A1,CC(C)(C)[Si](C)(C)Cl.OCCOCc1nccs1>>CC(C)(C)[Si](C)(C)OCCOCc1nccs1,,C1CCOC1,,c1c[nH]cn1,,val
US20080064715A1,Cc1ccc([Mg]Br)cc1.O=Cc1cc2ccncc2[nH]1>>Cc1ccc(C(O)c2cc3ccncc3[nH]2)cc1,,C1CCOC1,,,,val
US05599930,C1CNCCN1.CC(C)Nc1c(Cl)cncc1Cl>>CC(C)Nc1c(Cl)cncc1N1CCNCC1,,Cc1ccccc1C,,Cl,,val
US04291039,NCC(C(=O)O)c1c[nH]c2ccccc12.O=CC(=O)O>>O=C(O)C1CNC(C(=O)O)c2[nH]c3ccccc3c21,,O,,O=C([O-])[O-].[K+].[K+],,val
US20050107388A1,N#Cc1ccc(C(F)(F)F)cc1[N+](=O)[O-].OCCN1CCOCC1>>N#Cc1ccc(C(F)(F)F)cc1OCCN1CCOCC1,,CN(C)C=O,O,[K+].[OH-],,val
US06235900B1,Cc1cc[nH]n1.Cc1ccc(F)cc1C(=O)N1Cc2cccnc2Nc2ccccc21>>Cc1ccn(-c2ccc(C)c(C(=O)N3Cc4cccnc4Nc4ccccc43)c2)n1,,CCCCCC,,[H-].[Na+],,val
US04517130,C#N.CC(C)C=O.Nc1ccc(C(F)(F)F)cc1>>CC(C)C(C#N)Nc1ccc(C(F)(F)F)cc1,,O,,,,val
US20050148623A1,COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCN(Cc2ccccc2)C1=O)C(C)(C)C)C(C)(C)C.C[C@H](NC(=O)OC(C)(C)C)C(=O)O>>COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](OC(=O)[C@H](C)NC(=O)OC(C)(C)C)[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCN(Cc2ccccc2)C1=O)C(C)(C)C)C(C)(C)C,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20120065396A1,Cc1c(Br)cccc1C(=O)NCc1ccc(C(=O)Nc2ccccc2N)cc1.OB(O)c1ccccc1>>Cc1c(C(=O)NCc2ccc(C(=O)Nc3ccccc3N)cc2)cccc1-c1ccccc1,,C1COCCO1,O,CCOC(C)=O,O=C([O-])O.[Na+],val
US20040063757A1,N#C/C(=C\c1ccccc1)C(N)=O>>NCC(Cc1ccccc1)C(N)=O,[Pd],CCO,,Cl,,val
US20060122263A1,C=CCO[C@@H](CC=C)C(c1ccccc1)c1ccccc1>>C1=CC[C@@H](C(c2ccccc2)c2ccccc2)OC1,,c1ccccc1,,,,val
US20150203515A1,COC(=O)C1CC2CCCC(C1)N2C(C)c1ccc2c(C(F)(F)F)c(OC3CCC(C(F)(F)F)CC3)ccc2c1>>COC(=O)C1CC2CCCC(C1)N2[C@@H](C)c1ccc2c(C(F)(F)F)c(O[C@H]3CC[C@@H](C(F)(F)F)CC3)ccc2c1,,CO,,O=C=O,,val
US05945564,CO.O=C1CCC(=O)NC1.OCCO>>COC1(OC)CCC(=O)NC1,,OCCO,,CCO,,val
US20160075720A1,C[C@@H]1CN(C(=O)OC(C)(C)C)c2c(sc3ccc4c(ccc[n+]4[O-])c23)C(=O)N1C(=O)OC(C)(C)C.O=P(Br)(Br)Br>>C[C@@H]1CN(C(=O)OC(C)(C)C)c2c(sc3ccc4nc(Br)ccc4c23)C(=O)N1C(=O)OC(C)(C)C,,CN(C)C=O,O,,,val
US20050049250A1,CCOC(=O)C1CCN(S(=O)(=O)c2ccc(OCC)c(-c3nn4c(C5CCCC5)nc(C)c4c(=O)[nH]3)c2)CC1>>CCOc1ccc(S(=O)(=O)N2CCC(C(=O)O)CC2)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1,,CO,O,[Na+].[OH-],,val
US20040092582A1,CN.N#Cc1cccc(C(=O)O)c1>>CNC(=O)c1cccc(C#N)c1,,C1CCOC1,,CO,,val
US20030078251A1,COC(=O)C(Oc1ccc([N+](=O)[O-])cc1)C(C)=O>>COC(=O)c1oc2ccc([N+](=O)[O-])cc2c1C,,O=S(=O)(O)O,,,,val
US20050080074A1,CC(C)(C)OC(=O)N1CCN2C(=O)c3c(cc(-c4ccco4)cc3C(F)(F)F)[C@@H]2C1.Cl>>Cl.O=C1c2c(cc(-c3ccco3)cc2C(F)(F)F)[C@@H]2CNCCN12,,CCOCC,,,,val
US20120245144A1,CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(-c3ccccc3S(=O)(=O)NC(C)(C)C)cc1OCC2>>CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(-c3ccccc3S(N)(=O)=O)cc1OCC2,,O=C(O)C(F)(F)F,,,,val
US05175301,CN.CSC(=C[N+](=O)[O-])NCc1cccnc1>>CNC(=C[N+](=O)[O-])NCc1cccnc1,,CCO,,,,val
US20060135578A1,CC(=O)C(C)=NO.CCOC(=O)C=CC=O.Cl>>CCOC(=O)/C=C/c1nc(CCl)c(C)o1,,CCCCCC,CCOC(C)=O,CCOCC,,val
US20090176765A1,CC(C)c1cc(Cl)nnc1Cl.N#CCc1ccc(F)c(C#N)c1>>CC(C)c1cc(C(C#N)c2ccc(F)c(C#N)c2)nnc1Cl,,C1CCOC1,,[H-].[Na+],,val
US20030166637A1,C1CNCCN1.Cn1c(Cl)nc2ccccc21>>Cn1c(N2CCNCC2)nc2ccccc21,,O,,Cl,,val
US20110112103A1,O=Cc1ccc(Br)cc1.c1ccc2c(c1)CCCN2>>Brc1ccc(CN2CCCc3ccccc32)cc1,,ClCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US20120040953A1,CC(C)(C)OC(=O)N[C@H]1CNC[C@@H]1c1cc(F)ccc1F.CC(C)OC(=O)N1CCC(O[C@H](C)c2noc(-c3cnc(Cl)nc3)n2)C1>>CC(C)OC(=O)N1CC[C@@H](O[C@H](C)c2noc(-c3cnc(N4C[C@H](NC(=O)OC(C)(C)C)[C@@H](c5cc(F)ccc5F)C4)nc3)n2)C1,,CC(C)(C)O,,CCN(C(C)C)C(C)C,,val
US20040077670A1,CO.COc1ccccc1Oc1c(Cl)nc(-c2ccncc2)nc1NS(=O)(=O)Nc1ccc(C(C)C)cc1>>COc1ccccc1Oc1c(NS(=O)(=O)Nc2ccc(C(C)C)cc2)nc(-c2ccncc2)nc1OC,,CN(C)C=O,,C1CCOC1,[H-].[Na+],val
US08247401B2,CC(C)(C)OC(=O)c1cc(Br)cc(C(N)C(F)(F)F)c1.Cc1ccc([Zn]Br)nc1>>Cc1ccc(-c2cc(C(=O)OC(C)(C)C)cc(C(N)C(F)(F)F)c2)nc1,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,C1COCCO1,,,,val
US05929085,CN1CCNCc2cc([N+](=O)[O-])ccc21.Cl>>CN1CCNCc2cc(N)ccc21.Cl,,CO,,,,val
US05106871,COCOc1cc(CCC(=O)c2c(OC)cc(OC)c(CCC(C)C)c2OCC(=O)OC)ccc1OC>>COC(=O)COc1c(CCC(C)C)c(OC)cc(OC)c1C(=O)CCc1ccc(OC)c(O)c1,,CO,,Cl,,val
US20110046097A1,O=C1CCC(=O)N1Cl.O=C1Nc2cc(Br)ccc2C12CCCC2>>O=C1Nc2cc(Br)c(Cl)cc2C12CCCC2,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US05608056,C=CCOC(=O)C1=C(S[C@H]2C[C@@H](CCCn3ccnc3)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12.CI>>C=CCOC(=O)C1=C(S[C@H]2C[C@@H](CCC[n+]3ccn(C)c3)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12.[I-],,CC(C)=O,,,,val
US20130252944A1,C=CC(=O)c1cn(Cc2ccc(OC)cc2)nc1C(O)C(F)(F)F>>COc1ccc(Cn2cc3c(n2)C(C(F)(F)F)OCCC3=O)cc1,,ClCCl,,CCOCC,FB(F)F,val
US20130338134A1,CCN1CCNCC1.COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCC=O)cc4c3N(C)C2=O)c1F>>CCN1CCN(CCCc2cc3c4c(cnc3[nH]2)CN(c2c(F)c(OC)cc(OC)c2F)C(=O)N4C)CC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20050277652A1,C1CCNC1.Nc1cc(Oc2ccc(N)c(F)c2)ccn1.O=C(Cl)Oc1ccccc1>>Nc1ccc(Oc2ccnc(NC(=O)N3CCCC3)c2)cc1F,,C1CCOC1,CN(C)C=O,CCN(CC)CC,,val
US06432993B1,CN(C(=O)OC(C)(C)C)c1cc(Oc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)ccc1N.O=C(O)COc1ccc(CC2SC(=O)NC2=O)cc1>>CN(C(=O)OC(C)(C)C)c1cc(Oc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)ccc1NC(=O)COc1ccc(CC2SC(=O)NC2=O)cc1,,C1CCOC1,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US04492692,FC(F)(F)CN=C=S.NCCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)n1>>Fc1nc(CCCNC(=S)NCC(F)(F)F)cn1C(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,,,val
US20070088071A1,CC(C)(C)c1ccc(CBr)cc1.CCOC(=O)c1cc2cc(Cl)ccc2[nH]1>>CCOC(=O)c1cc2cc(Cl)ccc2n1Cc1ccc(C(C)(C)C)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20040023961A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccncc3)c3ccccc23)cc1.NNC1CCCCC1>>CC(C)(C)c1cc(NC(=O)Nc2ccc(OCc3ccncc3)c3ccccc23)n(C2CCCCC2)n1,,CCCCCC,CCOC(C)=O,,,val
US06235731B1,CC1(C)OCc2ccc(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc2CO1>>CC(C)(C)[Si](OCc1ccc(CO)c(CO)c1)(c1ccccc1)c1ccccc1,,C1CCOC1,O,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20030008361A1,CCOC(=O)C(OC(C)C)P(=O)(OCC)OCC.O=Cc1ccc(OCc2ccccc2)cc1>>CCOC(=O)C(Cc1ccc(O)cc1)OC(C)C,[Pd],,,,,val
US20140163024A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(Cl)nc2)CC1>>Clc1ccc(OC2CCNCC2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04950763,CC(=O)O.COC(=O)c1cccnc1>>CC(=O)c1cccnc1,,O,,,,val
US20130296354A1,CC(C)OC(=O)Cl.CS(=O)(=O)N1CC=C(c2cc3c(cn2)OC2(C3)CC3(CCNCC3)C2)CC1>>CC(C)OC(=O)N1CCC2(CC1)CC1(Cc3cc(C4=CCN(S(C)(=O)=O)CC4)ncc3O1)C2,,ClCCl,,CCN(CC)CC,,val
US04808595,Cc1cc2oc(S(=O)(=O)N=CN(C)C)cc2c[n+]1[O-]>>CN(C)C=NS(=O)(=O)c1cc2cnc(CO)cc2o1,,CC(=O)OC(C)=O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20080166359A1,CC(C)N.O=CCC1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1>>CC(C)NCCC1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110230518A1,N#Cc1ccc2[nH]cnc2c1.NO>>NC(=NO)c1ccc2[nH]cnc2c1,,CCO,,,,val
US20110046169A1,O=C(Nc1ccc(O)c(F)c1)OCc1ccccc1.O=[N+]([O-])c1ccc(Cl)cn1>>O=C(Nc1ccc(Oc2ccc([N+](=O)[O-])nc2)c(F)c1)OCc1ccccc1,,CS(C)=O,O,O=C([O-])[O-].[Cs+].[Cs+],O=C([O-])O.[Na+],val
US20050209241A1,CC(C)(C)OC(=O)N1CCNCC1.FC(F)(F)c1cnnc(Cl)c1>>CC(C)(C)OC(=O)N1CCN(c2cc(C(F)(F)F)cnn2)CC1,,CC(=O)N(C)C,CCOC(C)=O,,,val
US20090036450A1,CCOC(=O)c1nc(C)c(C(=O)OC(C)(C)C)s1>>CCOC(=O)c1nc(C)c(C(=O)O)s1,,Cc1ccccc1,,O=C(O)C(F)(F)F,,val
US05273975,BrBr.COC(=O)CC(=O)OCc1ccccc1>>COC(=O)C(Br)C(=O)OCc1ccccc1,,ClC(Cl)(Cl)Cl,,,,val
US20150329538A1,CCOC(=O)c1cc(-c2c(F)ccc3nc(C)c(NC4CC4)nc23)[nH]c1C1(NC(=O)OC(C)(C)C)CC1.Cl>>Cc1nc2ccc(F)c(-c3cc(C(=O)O)c(C4(N)CC4)[nH]3)c2nc1NC1CC1.Cl,,C1COCCO1,,O,[Na+].[OH-],val
US20130158034A1,CC(C)(C)[S@](=O)/N=C/c1ncccc1C(F)(F)F.Clc1ccc([Mg]Br)cc1Cl>>CC(C)(C)[S@](=O)N[C@@H](c1ccc(Cl)c(Cl)c1)c1ncccc1C(F)(F)F,,C1CCOC1,CCOC(C)=O,O,[Cl-].[NH4+],val
US20070197512A1,CC(C)(Br)C(=O)Br.Cc1cc(C)c(O)c(N)c1>>Cc1cc(C)c(O)c(NC(=O)C(C)(C)Br)c1,,O,,CCOC(C)=O,O=C([O-])O.[Na+],val
US20070249670A1,CC(C)(C)OC(=O)c1cc(Br)sc1N.O=C=Nc1c(Cl)cc(OC(F)(F)F)cc1Cl>>CC(C)(C)OC(=O)c1cc(Br)sc1NC(=O)Nc1c(Cl)cc(OC(F)(F)F)cc1Cl,,CN(C)C=O,,CCN(CC)CC,,val
US20050277772A1,C=Cc1ccccc1.[B]1Oc2ccccc2O1>>C[C@H](O)c1ccccc1,[Rh],ClCCl,,Cc1ccccc1,,val
US20040209905A1,COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.O=C=Nc1ccc(F)cc1F>>COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC,,ClC(Cl)Cl,,,,val
US20160264553A1,Cc1cccc(-c2ncccc2-c2ccc3ncc(C(=O)O)n3c2)n1.NCC(F)F>>Cc1cccc(-c2ncccc2-c2ccc3ncc(C(=O)NCC(F)F)n3c2)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04006155,O=C1C=CC(=O)N1Sc1ccccc1.Sc1ccccc1>>c1ccc(SSc2ccccc2)cc1,,c1ccccc1,,,,val
US20110319618A1,Cc1ncnc(Cl)c1C#Cc1ccc(C(F)(F)F)cc1.N>>Cc1ncnc(N)c1C#Cc1ccc(C(F)(F)F)cc1,,CCO,,,,val
US20110150834A1,CC(=O)Cl.CCOC(=O)Cn1c(C)cc(Cc2ccccc2S(=O)(=O)c2ccccc2)c1C>>CCOC(=O)Cn1c(C)c(Cc2ccccc2S(=O)(=O)c2ccccc2)c(C(C)=O)c1C,,CC#N,,ClCCl,O=C([O-])O.[Na+],val
US20100004249A1,CC(C)(C)OC(=O)N1CCNC(CO)C1.O=C=Nc1cccnc1>>CC(C)(C)OC(=O)N1CCN(C(=O)Nc2cccnc2)C(CO)C1,,C1CCOC1,,,,val
US20100081643A1,COC(=O)c1cc(O)ccc1C.Cn1ccc2cc(-c3c(F)cc4c(nc(S(C)(=O)=O)n4Cc4ccc(-c5ccccc5)cc4)c3F)ccc21>>COC(=O)c1cc(Oc2nc3c(F)c(-c4ccc5c(ccn5C)c4)c(F)cc3n2Cc2ccc(-c3ccccc3)cc2)ccc1C,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20110021520A1,NC(CO)(CO)c1cc(Br)ccc1F.O=C(Cl)CCl>>O=C(CCl)NC(CO)(CO)c1cc(Br)ccc1F,,CC#N,,CO,O=C([O-])[O-].[K+].[K+],val
US20070015761A1,Brc1cccnc1.CC1(C)CC(O)C(N)c2ccccc21.CCN(CC)C(=O)c1ccccc1O>>CC1(C)CC(O)C(Nc2cncnc2)c2ccccc21,I[Cu]I,,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20080146547A1,CN(C)C=O.Clc1nncc2cc(Br)ccc12>>CN(C)c1nncc2cc(Br)ccc12,,CCOC(C)=O,,,,val
US04186135,CN1CCN(N)CC1.O=C(Cl)c1cc([N+](=O)[O-])cc2c1OCCO2>>CN1CCN(NC(=O)c2cc([N+](=O)[O-])cc3c2OCCO3)CC1,,CCC(C)=O,,O,,val
US05756504,COc1cc(OC2CCNCC2)ccc1CC(=O)N1CCN(c2ccccc2C)CC1C(N)=O.O=C(O)Cc1c[nH]cn1>>COc1cc(OC2CCN(C(=O)Cc3c[nH]cn3)CC2)ccc1CC(=O)N1CCN(c2ccccc2C)CC1C(N)=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20150011533A1,CCOP(=O)(N[C@H]1CN(C(=O)OCc2ccccc2)CC[C@@H]1C1CC1)OCC>>CCOP(=O)(N[C@H]1CNCC[C@@H]1C1CC1)OCC,[Pd],CO,,N#N,,val
US20120289493A1,Cc1noc(CCl)n1.O=c1[nH]ncc2ccc(-c3ccc(OC(F)(F)F)cc3)cc12>>Cc1noc(Cn2ncc3ccc(-c4ccc(OC(F)(F)F)cc4)cc3c2=O)n1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04036843,CC1(C)COC(c2ccccc2)=N1.Cl.O>>CC(C)(N)COC(=O)c1ccccc1.Cl,,C1CCOC1,Cl,,,val
US20110230493A1,Cn1nnnc1N.O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCC2(CC1)C[C@H](c1cccc(-c3ccc(F)cc3)c1)CO2>>Cn1nnnc1NC(=O)N1CCC2(CC1)C[C@H](c1cccc(-c3ccc(F)cc3)c1)CO2,,CC(=O)N(C)C,CCOC(C)=O,[H-].[Na+],,val
US20050250810A1,CC(=O)Cl.Nc1ncc(Br)cn1>>CC(=O)Nc1ncc(Br)cn1,,ClCCl,,Cc1cccc(C)n1,,val
US20150259323A1,CC(C)(C)OC(=O)N1CCC[C@H](O)C1.CCOc1ccccc1O>>CCOc1ccccc1O[C@@H]1CCCN(C(=O)OC(C)(C)C)C1,,Cc1ccccc1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04238487,CCOC(=O)c1ccc2cc(CCCCN3C(=O)c4ccccc4C3=O)oc2c1>>CCOC(=O)c1ccc2cc(CCCCN)oc2c1,,CCO,,NN,O,val
US20090239845A1,Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCc1ccccc1.O=C(Cl)C(=O)Cl>>Cc1cc(C(=O)Cl)nn1Cc1cc(Cl)ccc1OCc1ccccc1,CN(C)C=O,ClCCl,,,,val
US05254677,N#Cc1ccccc1O.O=[N+]([O-])O>>N#Cc1cc([N+](=O)[O-])ccc1O,,CCOC(C)=O,,O,O=S(=O)(O)O,val
US20130085132A1,C[C@@H](O)C(F)(F)F.Clc1cccc(CBr)c1>>C[C@@H](OCc1cccc(Cl)c1)C(F)(F)F,,CN(C)C=O,,O,[H-].[Na+],val
US20120046292A1,CCOC(=O)c1ccc(C2CC2)c(Cl)c1>>O=C(O)c1ccc(C2CC2)c(Cl)c1,,CCO,,C1CCOC1,[Na+].[OH-],val
US20110112151A1,O=C(CBr)C12CC3CC(CC(C3)C1)C2.Sc1ccncc1>>O=C(CSc1ccncc1)C12CC3CC(CC(C3)C1)C2,,CC#N,,CCN(CC)CC,,val
US04960776,NCCN1CCOCC1.O=C(n1ccnc1)n1ccnc1.c1ccc(N2CCNCC2)cc1>>O=C(NCCN1CCOCC1)N1CCN(c2ccccc2)CC1,,C1CCOC1,,,,val
US20070259965A1,CN(C[C@H]1CO1)S(=O)(=O)c1ccccc1[N+](=O)[O-].[N-]=[N+]=[N-]>>CN(C[C@H](O)CN=[N+]=[N-])S(=O)(=O)c1ccccc1[N+](=O)[O-],,CO,O,[Cl-].[NH4+],,val
US20070259869A1,O=C(Nc1ccc(SC(=O)c2ccccc2Cl)cc1)c1ccccc1Cl>>O=C(Nc1ccc(S)cc1)c1ccccc1Cl,,O,,CCOC(C)=O,[Na+].[OH-],val
US20100152192A1,Nc1nc(C(F)(F)F)cs1.O=C(O)c1c(/C=C/c2cccc(OC(F)F)c2OC2CCCC2)nc2sccn12>>O=C(Nc1nc(C(F)(F)F)cs1)c1c(/C=C/c2cccc(OC(F)F)c2OC2CCCC2)nc2sccn12,CN(C)c1ccncc1,C1CCOC1,CN(C)C=O,CCN=C=NCCCN(C)C,Cl,val
US05395815,CCCCCCCCCCCCCCCCCCN=C=O.Nc1ccc(O)cc1>>CCCCCCCCCCCCCCCCCCNC(=O)Nc1ccc(O)cc1,,CCC(C)=O,,,,val
US20090209607A1,COC(=O)c1scc(Br)c1C.Cn1nccc1B1OC(C)(C)C(C)(C)O1>>C=C(c1csc(C(=O)OC)c1C)N(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20100015053A1,COC(=O)c1ccc(S(=O)(=O)Nc2sc3ccccc3c2C)cc1.Fc1ccc(CBr)cc1C(F)(F)F>>COC(=O)c1ccc(S(=O)(=O)N(Cc2ccc(F)c(C(F)(F)F)c2)c2sc3ccccc3c2C)cc1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05204357,CCOC(=O)C(Cc1ccccc1)CS(=O)(=O)C1CCCCC1>>O=C(O)C(Cc1ccccc1)CS(=O)(=O)C1CCCCC1,,Cl,,,,val
US20090258854A1,BrCCOc1ccc(Oc2nc3ncccc3s2)cc1.c1cnc(OC2CCNCC2)nc1>>c1cnc(OC2CCN(CCOc3ccc(Oc4nc5ncccc5s4)cc3)CC2)nc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20140011676A1,CON1CCC2(CC1)C(=O)C(c1cc(C)c(C)cc1Cl)C(=O)N2C.O=S(=O)(Cl)Cl>>CON1CCC2(CC1)C(=O)C(Cl)(c1cc(C)c(C)cc1Cl)C(=O)N2C,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US06432993B1,COCCl.Cc1cc(OC(=O)C(C)(C)C)c(Cl)c(C)c1O>>COCOc1c(C)cc(O)c(Cl)c1C,,C1CCOC1,,[H-].[Na+],,val
US20160257651A1,Cc1cc(=O)n(C2CC2)c2cc(Br)c(F)cc12.O=[Se]=O>>O=Cc1cc(=O)n(C2CC2)c2cc(Br)c(F)cc12,,Cc1ccccc1C,,O,,val
US20150087639A1,CCN(CC)c1ccc(-c2ncc([N+](=O)[O-])s2)cc1>>CCN(CC)c1ccc(-c2ncc(N)s2)cc1,[Pd],CO,,,,val
US04624954,CCC1(CC)CCn2c(c(C)c3ccccc32)C1=O>>CCC1(CC)CCn2c(c(C)c3ccccc32)C1O,,CO,,[BH4-].[Na+],,val
US20110160206A1,CC(=O)OCc1nc(Cl)cc(N2CCCC2)n1>>OCc1nc(Cl)cc(N2CCCC2)n1,,C1CCOC1,CO,O,[Na+].[OH-],val
US20130317001A1,CS(=O)(=O)NC(=O)c1cc(Cl)c(F)cc1F.OCC1CN(C(c2ccccc2)c2ccccc2)C1>>CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CN(C(c3ccccc3)c3ccccc3)C2)cc1F,,CCOC(C)=O,CS(C)=O,C1CCOC1,CC(C)(C)[O-].[K+],val
US20140356322A1,C=CCOC(=O)[C@@H]1C[C@@H](OC(C)(C)C)CN1C(=O)Cc1cc(C)no1>>Cc1cc(CC(=O)N2C[C@H](OC(C)(C)C)C[C@H]2C(=O)O)on1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,C1COCCN1,,val
US20110118245A1,CC(C)(C#N)c1cccc(NC(=O)Oc2ccccc2)c1.COc1cc2ncnc(Sc3cccc(N)c3)c2cc1OC>>COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cccc(C(C)(C)C#N)c4)c3)c2cc1OC,CN(C)c1ccncc1,C1CCOC1,,,,val
US20080207645A1,CC1(C)Cc2c(C#N)c(S)nc(N3CCCC3)c2CO1.NC(=O)CCl>>CC1(C)Cc2c(c(N3CCCC3)nc3sc(C(N)=O)c(N)c23)CO1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US06962934B2,CC(C)CNC(=O)[C@@H](NC(=O)[C@H](C)NC[C@H](Cc1cc(F)cc(F)c1)NC(=O)OC(C)(C)C)C(C)C>>CC(C)CNC(=O)[C@@H](NC(=O)[C@H](C)NC[C@@H](N)Cc1cc(F)cc(F)c1)C(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090011994A1,CC(C)(O)COc1ccc(Br)cc1.O=c1[nH]ccnc1OCCc1ccc(Cl)cc1>>CC(C)(O)COc1ccc(-n2ccnc(OCCc3ccc(Cl)cc3)c2=O)cc1,[Cu]I,C1COCCO1,,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20060052371A1,COC(=O)c1ccccc1S.N#Cc1ccc(C#N)cc1>>N#Cc1ccc(-c2nc(=O)c3ccccc3s2)cc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20110183985A1,CC(=O)c1cc(Cl)c(C)c([N+](=O)[O-])c1-c1cccc(F)c1>>CC(=O)c1cc(Cl)c(C)c(N)c1-c1cccc(F)c1,[Pt],CO,,[H][H],,val
US20090170855A1,NCCN1CCCC1.O=c1c2ccccc2c2nc3ccc(Br)cn3c2n1-c1ccc([N+](=O)[O-])cc1>>O=c1c2ccccc2c2nc3ccc(NCCN4CCCC4)cn3c2n1-c1ccc([N+](=O)[O-])cc1,,C1COCCO1,,c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1,O=C([O-])[O-].[Cs+].[Cs+],val
US20080045521A1,COC(=O)[C@H](Cc1ccc(OCCc2ccc3c(n2)NCCN3C)cc1)NC(=O)c1c(Cl)cccc1Cl>>CN1CCNc2nc(CCOc3ccc(C[C@H](NC(=O)c4c(Cl)cccc4Cl)C(=O)O)cc3)ccc21,,CC(=O)N(C)C,O,[Li+].[OH-],,val
US20160031934A1,O=C(O)[C@H]1CCCN1.OC(O)C(Cl)(Cl)Cl>>O=C1OC(C(Cl)(Cl)Cl)N2CCC[C@H]12,,ClC(Cl)Cl,,O=S(=O)([O-])[O-].[Mg+2],,val
US05023275,O=c1ccsn1Cc1ccccc1>>O=c1ccsn1Cc1ccccc1,,O,,Cl,,val
US20140315861A1,CC(C)(O)C(C)(C)O.Cl.O=[N+]([O-])c1cccc(CS(=O)(=O)NCB(O)O)c1>>CC(C)(O)C(C)(C)O.Cl.Nc1cccc(CS(=O)(=O)NCB(O)O)c1,[Pd],CCOC(C)=O,,,,val
US06566394B1,COC1(OC)C(NC(=O)c2ccccc2O)=CC(=O)C2OC21>>O=C(NC1=CC(=O)C2OC2C1=O)c1ccccc1O,,ClCCl,,CCOC(C)=O,,val
US20120010191A1,Cl.Cn1cc(Br)cc(Nc2ccc(OC3CN(C(=O)OC(C)(C)C)C3)cn2)c1=O>>Cl.Cn1cc(Br)cc(Nc2ccc(OC3CNC3)cn2)c1=O,,CO,,C1COCCO1,,val
US20080200507A1,BrP(Br)Br.COc1cccc(C2CCc3cc(OC)ccc3C2=O)c1>>COc1cccc(C2=C(Br)c3ccc(OC)cc3CC2)c1,,Cc1ccccc1,,,,val
US04323691,CCO.O=C(O)COc1ccc(C(=O)c2ccc(O)cc2)c(Cl)c1Cl>>CCOC(=O)COc1ccc(C(=O)c2ccc(O)cc2)c(Cl)c1Cl,,ClCCCl,,O=S(=O)(O)O,,val
US20030055265A1,CCOC(=O)C(Cc1ccc(O)c2ccccc12)OCC.Cc1oc(-c2ccccc2)nc1CCl>>CCOC(=O)C(Cc1ccc(OCc2nc(-c3ccccc3)oc2C)c2ccccc12)OCC,,CN(C)C=O,,[H-].[Na+],,val
US20140121198A1,N#CC[C@H]1CC[C@H](N)C[C@H]1NC(=O)OCc1ccccc1.O=[N+]([O-])c1cnc2ccsc2c1Cl>>N#CC[C@H]1CC[C@H](Nc2c([N+](=O)[O-])cnc3ccsc23)C[C@H]1NC(=O)OCc1ccccc1,,CC(C)O,,CCN(CC)CC,,val
US20040138450A1,COC(=O)/C=N/Nc1ccccc1Cl.O=C1CCC(=O)N1Br>>COC(=O)/C(Br)=N/Nc1ccccc1Cl,,C1CCOC1,,,,val
US20140057899A1,CS(=O)(=O)OC1CCc2c(-c3cnc4ccccc4c3)c3c(N)ncnc3n2C1.[N-]=[N+]=[N-]>>[N-]=[N+]=NC1CCc2c(-c3cnc4ccccc4c3)c3c(N)ncnc3n2C1,,CN(C)C=O,,O,,val
US20080096874A1,CCOC(=O)C(C)[C@@H]1CC[C@@H](c2ccc(N)cc2)CC1.COC(=O)C(=O)Cl>>CCOC(=O)C(C)[C@@H]1CC[C@@H](c2ccc(NC(=O)C(=O)OC)cc2)CC1,,ClCCl,,c1ccncc1,,val
US20020045615A1,COc1cccc2sc(N)nc12.Cc1ccc(C(=O)Cl)s1>>COc1cccc2sc(NC(=O)c3ccc(C)s3)nc12,,c1ccncc1,,,,val
US20070191395A1,CC(C)c1c[nH]c(COCc2ccccc2)n1>>CC(C)c1c[nH]c(CO)n1,[Pd],CCO,,Cl,,val
US20110152240A1,CC(C)(C)OC(=O)N(c1nc(-c2cccc(OC(F)(F)F)c2)nc2ccnn12)C1CC1.O=C(O)C(F)(F)F>>O=Cc1cnn2c(NC3CC3)nc(-c3cccc(OC(F)(F)F)c3)nc12,,ClCCl,,,,val
US04780452,OC[C@H]1O[C@@H](n2cnc3c(Nc4ccccc4)cc(Cl)nc32)[C@H](O)[C@@H]1O>>OC[C@H]1O[C@@H](n2cnc3c(Nc4ccccc4)ccnc32)[C@H](O)[C@@H]1O,[Pd],O,,,,val
US05637579,C[C@@]1(/C=C/CO)S[C@@H]2CC(=O)N2[C@H]1C(=O)OC(c1ccccc1)c1ccccc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>C[C@@]1(C=CC[n+]2ccccc2)S[C@@H]2CC(=O)N2[C@H]1C(=O)OC(c1ccccc1)c1ccccc1.O=S(=O)([O-])C(F)(F)F,,ClCCl,,,,val
US20030144274A1,BrBr.CC(C)(C)OC(=O)c1ccc(CNS(=O)(=O)c2ccccc2N)cc1>>CC(C)(C)OC(=O)c1ccc(CNS(=O)(=O)c2cc(Br)ccc2N)cc1,,CC(=O)O,,,,val
US20100278833A1,COC(=O)c1cc2[nH]cnc2cn1>>OCc1cc2[nH]cnc2cn1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050256218A1,CCOC(=O)CC(C(C)=O)C(C)=O.CI>>CCOC(=O)CC(C)(C(C)=O)C(C)=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05952321,C=CC[C@@H](NC(=O)N1C(=O)C(CC)(CC)[C@@H]1Oc1ccc(C(C)=O)cc1)c1ccc(C)cc1>>CCC[C@@H](NC(=O)N1C(=O)C(CC)(CC)[C@@H]1Oc1ccc(C(C)=O)cc1)c1ccc(C)cc1,[Pd],CCO,,,,val
US07094789B2,CC(C)(C)OC(=O)N1CCC(Nc2cccc3cncc(Br)c23)CC1.CO>>COc1cncc2cccc(NC3CCN(C(=O)OC(C)(C)C)CC3)c12,[Cu]I,CO,c1ccncc1,O,C[O-].[Na+],val
US20070208062A1,CC1(C)OB(c2ccc(N3C[C@H](Cn4ccnn4)OC3=O)cc2F)OC1(C)C.OCCOC[C@@H]1CC(c2ccc(Br)cn2)=NO1>>O=C1O[C@H](Cn2ccnn2)CN1c1ccc(-c2ccc(C3=NO[C@@H](CCCO)C3)nc2)c(F)c1,c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd-4]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20120202785A1,CC(C)(C)OC(=O)N[C@@H]1CCCN(CCOC(=O)C(C)(C)C)C1>>CC(C)(C)C(=O)OCCN1CCC[C@@H](N)C1,,ClCCl,,Cc1ccccc1,O=C(O)C(F)(F)F,val
US04933350,CCOC(=O)CC(=O)CC(O)/C=C/c1c(-c2ccccc2)c2c3ccccc3ccn2c1C(C)C>>CCOC(=O)CC(=O)CC(O)CCc1c(-c2ccccc2)c2c3ccccc3ccn2c1C(C)C,[Pd],CCO,,,,val
US20160243100A1,COc1ccc(S(=O)(=O)C(C)(F)C2CCNCC2)cn1.O=C(Nc1ccnnc1)Oc1ccccc1>>COc1ccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3ccnnc3)CC2)cn1,,CS(C)=O,,CCN(CC)CC,Cl,val
US20070208007A1,CCc1ccc(C)nc1.O=C(OO)c1cccc(Cl)c1>>CCc1ccc(C=O)nc1,,ClCCl,,[Na+].[OH-],,val
US05514680,CCOC(=O)C(=O)OCC.N#Cc1ccc(N)c(N)c1>>N#Cc1ccc2[nH]c(=O)c(=O)[nH]c2c1,,CC(=O)O,,,,val
US20100093803A1,CCOC(=O)C(=CN(C)C)c1cccnc1.N#Cc1ccnc(NN)c1>>N#Cc1ccnc(-n2[nH]cc(-c3cccnc3)c2=O)c1,,CC(=O)O,,,,val
US05602277,CCOC(=O)Cc1cc(C(=O)OC)ccc1NC(C)=O>>COC(=O)c1ccc(NC(C)=O)c(CC(=O)O)c1,,CO,,[Na+].[OH-],,val
US20150005279A1,CN(c1ccc(C(N)=O)c2[nH]c(I)cc12)C1CN(C(=O)OC(C)(C)C)C1.OC/C=C\CO>>CN(c1ccc(C(N)=O)c2[nH]c(C3C=COC3)cc12)C1CN(C(=O)OC(C)(C)C)C1,Cl[Pd]Cl,CN1CCCC1=O,,O=C([O-])O.[Na+],,val
US20050261496A1,CCCI.NC(=O)c1[nH]c2ccc(O)cc2c1S(=O)(=O)N1CCOCC1>>CCCOc1ccc2[nH]c(C(N)=O)c(S(=O)(=O)N3CCOCC3)c2c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20040248897A1,Cc1ccc(NS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-]>>Cc1ccc(NS(=O)(=O)c2ccccc2)cc1N,[Pd],CO,,[H][H],,val
US06455532B1,C[Si](C)(C)C#N.Cc1cc[n+]([O-])cc1F>>Cc1ccnc(C#N)c1F,,CC#N,,CCN(CC)CC,,val
US20100113441A1,CCOC(=O)NC(=CC#N)c1ccc(C(F)(F)F)cc1.NNC(=O)CN1CCOCC1>>Oc1nc(-c2ccc(C(F)(F)F)cc2)cc2nc(CN3CCOCC3)nn12,,CN1CCCC1=O,,CCOC(C)=O,O,val
US20040082607A1,CC(=O)Cl.CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2ccccc2)c2cc(-c3nc(N)cs3)ccc2c1=O>>CC(=O)Nc1csc(-c2ccc3c(=O)n(CC(C)C)c(CNC(=O)OC(C)(C)C)c(-c4ccccc4)c3c2)n1,,CC(=O)N(C)C,,O,,val
US06723722B1,CC(C)(C)OC(=O)CNS(=O)(=O)c1ccc2cc(Cl)ccc2c1.COC(=O)/C=C/CBr>>COC(=O)C=CCN(CC(=O)OC(C)(C)C)S(=O)(=O)c1ccc2cc(Cl)ccc2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050113580A1,COC(=O)c1cccc(O)c1.OCCCN(Cc1cccc(C(F)(F)F)c1Cl)CC(c1ccccc1)c1ccccc1>>COC(=O)c1cccc(OCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(c2ccccc2)c2ccccc2)c1,,C1CCOC1,O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070191431A1,COP(=O)(OC)C(=[N+]=[N-])C(C)=O.O=CC1CCN(C(=O)c2ccccc2)CC1>>C#CC1CCN(C(=O)c2ccccc2)CC1,,CCOCC,CO,O=C([O-])[O-].[K+].[K+],,val
US20080176830A1,O=C1CCC(=O)N1Br.O=C1NCCc2ccccc2N1>>O=C1NCCc2cc(Br)ccc2N1,,CN(C)C=O,,,,val
US20050153970A1,CC(C)(C)C(=O)Cl.CCCN(CCCc1ccc(F)cc1)C[C@@H]1C[C@H](N)CC[C@H]1NC(=O)OCc1ccccc1>>CCCN(CCCc1ccc(F)cc1)C[C@@H]1C[C@H](NC(=O)C(C)(C)C)CC[C@H]1NC(=O)OCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20100298288A1,CC(C)(C)OC(=O)NCC1CCCNC1.O=C(Cl)c1cccc(C(F)(F)F)c1>>CC(C)(C)OC(=O)NCC1CCCN(C(=O)c2cccc(C(F)(F)F)c2)C1,,ClCCl,,CCN(CC)CC,,val
US20160264567A1,C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)ncc2F)N1C(=O)OC(C)(C)C>>C[C@@H]1N[C@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)ncc2F)C[C@H]1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120172351A1,COC(=O)C[C@@H]1COc2cc(O)ccc21.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)C[C@@H]1COc2cc(OS(=O)(=O)C(F)(F)F)ccc21,,c1ccncc1,,,,val
US20080171740A1,CC(C)(C)OC(=O)NCCCCN(Cc1cn2c(N3CCCC3)cccc2n1)C1CCCc2cccnc21>>NCCCCN(Cc1cn2c(N3CCCC3)cccc2n1)C1CCCc2cccnc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040192670A1,CCOC(=O)C[C@H](NCCNCCCc1ccc2c(n1)NCCC2)c1ccc(OC)nc1.N#CN=C(Oc1ccccc1)Oc1ccccc1>>CCOC(=O)C[C@@H](c1ccc(OC)nc1)N1CCN(CCCc2ccc3c(n2)NCCC3)C1=NC#N,,CCOC(C)=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20050026964A1,O=C(OCC1c2ccccc2-c2ccccc21)n1ccc2cc([N+](=O)[O-])ccc21>>Nc1ccc2c(ccn2C(=O)OCC2c3ccccc3-c3ccccc32)c1,[Ni],C1CCOC1,,,,val
US20100305131A1,CCOC(=O)C(=O)CBr.CCOC(=O)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(N)=O>>CCOC(=O)C[C@@H](Cc1ccc(-c2ccccc2)cc1)Nc1nc(C(=O)OCC)co1,,CCO,,,,val
US20100041663A1,Cc1c(Cl)nnc(Cl)c1C.FC(F)(F)c1ccc(N2CCNCC2)nc1>>Cc1c(Cl)nnc(N2CCN(c3ccc(C(F)(F)F)cn3)CC2)c1C,,CN1CCCC1=O,,CCN(CC)CC,,val
US20110251418A1,CC(C)(C)OC(=O)N[C@@H](CO)C(=O)OC(C)(C)C.Cc1c(Cl)cc(N)cc1S(=O)(=O)O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1c(Cl)cc(NC(=O)OC[C@H](N)C(=O)O)cc1S(=O)(=O)O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110263612A1,COc1ccc2c(c1)CCC2.O=C1CCC(=O)N1Br>>COc1cc2c(cc1Br)CCC2,,CC#N,O,,,val
US20080070953A1,COC(=O)[C@@H]1CC(Oc2ccccc2)CN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C>>CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N1CC(Oc2ccccc2)C[C@H]1C(=O)O)C(C)C,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20150259358A1,CC(C)(C)OC(=O)c1ccc(NC=O)cc1>>[C-]#[N+]c1ccc(C(=O)OC(C)(C)C)cc1,,C1CCOC1,,O=P(Cl)(Cl)Cl,,val
US20070032486A1,COC(=O)c1cc(Cl)c(OC)c2c1OCCO2>>COc1c(Cl)cc(C(=O)O)c2c1OCCO2,,[Na+],[OH-],,,val
US05348962,COC(=O)c1ccc(Cl)cc1N.COc1cccc(CC(=O)Cl)c1>>COC(=O)c1ccc(Cl)cc1NC(=O)Cc1cccc(OC)c1,,ClCCl,,,,val
US06010981,BrBr.CSc1cccc(Cl)c1-c1ccccc1>>CSc1ccc(Br)c(Cl)c1-c1ccccc1,,ClCCCl,,O=S([O-])O.[Na+],,val
US20080045521A1,Cc1cc(CC(=O)OC(C)(C)C)nc2c1CCCN2C(=O)OC(C)(C)C>>Cc1cc(CCO)nc2c1CCCN2C(=O)OC(C)(C)C,,C1CCOC1,,[BH4-].[Li+],,val
US20040116469A1,CC[C@H](NC(=O)c1c(N2CCC[C@H]2C(=O)OC)c(-c2ccccc2)nc2ccccc12)c1ccccc1>>CC[C@H](NC(=O)c1c(N2CCC[C@H]2CO)c(-c2ccccc2)nc2ccccc12)c1ccccc1,,CC(C)(C)O,,CO,[BH4-].[Na+],val
US06534496B1,O=CO.c1ccc2c(c1)CCCNC2>>O=CN1CCCc2ccccc2C1,,CCOC(C)=O,,CC(=O)OC(C)=O,,val
US04675332,CC(C)Br.COC(=O)c1c(O)c2cc(OC)ccc2n1-c1ccccc1>>COC(=O)c1c(OC(C)C)c2cc(OC)ccc2n1-c1ccccc1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US04105790,COC(=O)COc1ccc(-c2ocnc2C(=O)OC)cc1.Cl>>COC(=O)COc1ccc(C(=O)C(N)C(=O)OC)cc1.Cl,,CO,,,,val
US20060030613A1,CC(C)(C)c1ccc(CN(CC(O)C(F)(F)F)C(=O)C(F)(F)F)cc1>>CC(C)(C)c1ccc(CNCC(O)C(F)(F)F)cc1,,CCO,CCOCC,Cl,[Na+].[OH-],val
US05036064,Cc1cc(SCC2=C(C(=O)O)N3C(=O)[C@@H](N)[C@H]3SC2)nc2ccnn12>>O=C(O)C1=CCSC2CC(=O)N12,,CC#N,,CCN(CC)CC,O,val
US20050250797A1,C#CC(C)(C)O.Nc1c(Cl)cc(I)c2c1OCO2>>CC(C)(O)C#Cc1cc(Cl)c(N)c2c1OCO2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,,CC(C)NC(C)C,,val
US20130109679A1,CC(C)OC(=O)N=NC(=O)OC(C)C.CC(CO)CNC(=O)OC(C)(C)C.CCOC(=O)c1ccc2cc(C(=O)OCC)[nH]c2c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1ccc2cc(C(=O)OCC)[nH]c2c1.CCOC(=O)c1ccc2cc(C(=O)OCC)n(CC(C)CNC(=O)OC(C)(C)C)c2c1,,C1CCOC1,,,,val
US20070185165A1,Cc1nonc1C(=O)Nc1cccc(C#N)c1.NO>>Cc1nonc1C(=NO)Nc1cccc(C#N)c1,,c1ccccc1,,ClP(Cl)(Cl)(Cl)Cl,,val
US20100298340A1,CC(C)(C)OC(=O)NC(=N)Nc1nc(C(=O)O)cs1.Nc1cccc2cc3ccccc3cc12>>N=C(N)Nc1nc(C(=O)Nc2cccc3cc4ccccc4cc23)cs1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20160272637A1,Nc1ccc([N+](=O)[O-])cn1.O=C(CBr)c1ccc(F)cc1>>O=[N+]([O-])c1ccc2nc(-c3ccc(F)cc3)cn2c1,,O,,C1CN2CCN1CC2,,val
US20130338139A1,COCOCc1cnc2c(c1)c1ncnn1c(=O)n2Cc1ccc(OC)cc1>>COc1ccc(Cn2c(=O)n3ncnc3c3cc(CO)cnc32)cc1,,CO,,Cl,,val
US20070275987A1,N#Cc1cccnc1N.O=C(Cl)COCCc1ccccc1>>N#Cc1cccnc1NC(=O)COCCc1ccccc1,CN(C)c1ccncc1,ClCCl,c1ccncc1,,,val
US20040209886A1,CCOC(=O)c1ccccc1C(=O)Nn1cc(C(=O)OCC)c(O)c1C(=O)OCC.COS(=O)(=O)OC>>CCOC(=O)c1cn(N2C(=O)c3ccccc3C2=O)c(C(=O)OCC)c1OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05571843,BrBr.O=C1CC(=O)c2cc(O)ccc21>>O=C1c2ccc(O)cc2C(=O)C1Br,,ClC(Cl)Cl,,,,val
US20090048213A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)c1cc(F)c(F)c(F)c1>>C[C@@H](O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)[C@H](NC(=O)OC(C)(C)C)c1cc(F)c(F)c(F)c1,,CCOC(C)=O,O,CN(C)C=O,c1c[nH]cn1,val
US20060094761A1,CCCc1nc(C)c(OC(C)=O)c(C)c1CO>>CCCc1nc(C)c(O)c(C)c1CO,,Cl,,,,val
US04550107,C1CN[C@H](CN2CCOCC2)C1.O=C1Nc2cccnc2N(C(=O)CCl)c2ccccc21>>O=C1Nc2cccnc2N(C(=O)CN2CCC[C@H]2CN2CCOCC2)c2ccccc21,,CCO,,CCOC(C)=O,CO,val
US03952013,C=CCBr.CCOC(=O)c1cc(=O)c2cc(O)ccc2s1>>C=CCOc1ccc2sc(C(=O)OCC)cc(=O)c2c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04139545,CC1=C(C)C(=O)C(CCCCCC(=O)O)=C(C)C1=O.CCO>>CCOC(=O)CCCCCC1=C(C)C(=O)C(C)=C(C)C1=O,O=S(=O)(O)O,,,O,,val
US05135953,Cc1ccc(Oc2c(C)cc(N)c(C)c2Cl)c(C)c1.O=C=NC(=O)c1c(F)cccc1F>>Cc1ccc(Oc2c(C)cc(NC(=O)NC(=O)c3c(F)cccc3F)c(C)c2Cl)c(C)c1,,CCCCCC,Cc1ccccc1,,,val
US20160145219A1,C=C(OC)[Sn](CCCC)(CCCC)CCCC.O=C1OCCN1Cc1cc(Br)ccc1Cl>>CC(=O)c1ccc(Cl)c(CN2CCOC2=O)c1,,Cl,,C1COCCO1,,val
US20110190227A1,CCOC(=O)Cc1cccc(Oc2ccc(Br)cc2CBr)c1.Sc1ccccc1>>CCOC(=O)Cc1cccc(Oc2ccc(Br)cc2CSc2ccccc2)c1,,C1COCCO1,,[H-].[Na+],,val
US20060264429A1,O=C(CCl)c1cc(Cl)c(O)cc1F>>Oc1cc(F)c(CCCl)cc1Cl,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20100184739A1,Cc1ccc(N)cc1N.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1ccc(NC(=O)C(F)(F)F)cc1NC(=O)C(F)(F)F,,c1ccncc1,,,,val
US20110166163A1,COC(=O)CCCCCNc1ncnc2oc(Br)c(-c3ccc(OC)cc3)c12.OB(O)c1cccnc1>>COC(=O)CCCCCNc1ncnc2oc(-c3cccnc3)c(-c3ccc(OC)cc3)c12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CS(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20160145247A1,CC(C)(C)OC(=O)NCc1cccc(-c2cccc(N)c2)c1.COC(=O)Cc1ccccc1C=O>>COC(=O)Cc1ccccc1CNc1cccc(-c2cccc(CNC(=O)OC(C)(C)C)c2)c1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05665718,CCNCC.CN1Cc2c(-c3noc(CCl)n3)ncn2-c2ccccc2C1=O>>CCN(CC)Cc1nc(-c2ncn3c2CN(C)C(=O)c2ccccc2-3)no1,,CN(C)C=O,,,,val
US20050148652A1,Nc1ccc(S(F)(F)(F)(F)F)cc1.O=N[O-]>>Oc1ccc(S(F)(F)(F)(F)F)cc1,,O,,O=S(=O)(O)O,,val
US04960776,CN(C)CCN.CN(C)CCNC(=O)N1CCN(c2ccc(F)cc2)CC1.NC(=O)c1ccc(N2CCNCC2)cc1>>CN(C)CCNC(=O)N1CCN(c2ccc(C(N)=O)cc2)CC1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US06083952,O=C1C=CN(C(=O)c2c(Cl)cccc2Br)CC1>>O=C1CCN2C(=O)c3c(Cl)cccc3C2C1,,CN(C)C=O,,CCN(CC)CC,O=CO,val
US05928999,Cn1nc(-c2ccc(Cl)c(S(=O)(=O)Cl)c2)c(Cl)c1OC(F)F.NC1CC1>>Cn1nc(-c2ccc(Cl)c(S(=O)(=O)NC3CC3)c2)c(Cl)c1OC(F)F,,C1CCOC1,,,,val
US20080032998A1,COc1ccncc1.C[Mg]Cl.O=C(Cl)Oc1ccccc1>>CC1CC(=O)C=CN1C(=O)Oc1ccccc1,,C1CCOC1,,Cl,,val
US20080176829A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=S(=O)(c1ccccc1)n1ccc2c3c(ccc21)OCCNC3>>CC(C)(C)OC(=O)N1CCOc2ccc3c(ccn3S(=O)(=O)c3ccccc3)c2C1,,ClCCl,,,,val
US06376657B1,CC(=O)O[C@@H]1C[C@H]2[C@@H](CC=C3C[C@@H](O)CC[C@@]32C)C2=CC[C@H](C3(C)OCCO3)[C@]21C.Cc1ccc(S(=O)(=O)Cl)cc1>>CC(=O)O[C@@H]1C[C@H]2[C@@H](CC=C3C[C@@H](OS(=O)(=O)c4ccc(C)cc4)CC[C@@]32C)C2=CC[C@H](C3(C)OCCO3)[C@]21C,,c1ccncc1,,O,,val
US20100331312A1,C1CCNCC1.CC(=O)OCC(=O)N1CCc2cc(-c3ccc(CCOS(=O)(=O)c4ccc(C)cc4)cc3)ccc2C1>>CC(=O)OCC(=O)N1CCc2cc(-c3ccc(CCN4CCCCC4)cc3)ccc2C1,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20050153970A1,[N-]=[N+]=NCCCc1ccc(F)cc1>>NCCCc1ccc(F)cc1,[Pd],CO,,,,val
US04060615,CCNC(=O)N1CCN(C(=O)C2CCCC2)CC1.COc1cc(N)c(C#N)cc1OC>>COc1cc2cncnc2cc1OC,,O,,Cl,[H-].[Na+],val
US06387940B1,BrCc1ccccc1.Ic1n[nH]c2ccccc12>>Ic1nn(Cc2ccccc2)c2ccccc12,,C1CCOC1,O,CCOCC,[H-].[Na+],val
US04140775,O=[N+]([O-])c1ccc(CCl)cc1.c1ccc(N2CCNCC2)cc1>>O=[N+]([O-])c1ccc(CN2CCN(c3ccccc3)CC2)cc1,,CCN(CC)CC,,Cl,Cl,val
US20030065176A1,C=CC(O)c1ccc(C#N)cc1.ClCCCl>>N#Cc1ccc(C=CCCl)cc1,,ClCCCl,,O=S(Cl)Cl,,val
US20010027197A1,CNC.Fc1cc2ncnc(Nc3cccc(Br)c3)c2cn1>>CN(C)c1cc2ncnc(Nc3cccc(Br)c3)c2cn1,,CC(C)O,,CCN(CC)CC,Cl,val
US20090270405A1,COc1ccc(CNc2cnc3cc(C)ccc3n2)c(OC)c1.O=C(O)C(F)(F)F>>Cc1ccc2nc(N)cnc2c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20060287287A1,O=C1c2ccccc2C(=O)N1Cc1cc(Cl)cc(Br)c1>>NCc1cc(Cl)cc(Br)c1,,CCO,,NN,O,val
US20160102059A1,CCOP(C)(=O)c1ccc(Nc2cc(Oc3ccc(NC(=O)OC(C)(C)C)c4ccccc34)ccn2)cc1N(C)C>>CCOP(C)(=O)c1ccc(Nc2cc(Oc3ccc(N)c4ccccc34)ccn2)cc1N(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US05117000,C=O.CC(C)c1ccc(C(N)=O)cc1.c1ccsc1>>CC(C)c1ccc(C(=O)NCc2cccs2)cc1,,O=CO,,,,val
US20070142413A1,Clc1ncc(Cl)c(Cl)n1.Nc1cc(Cc2ccccc2)n[nH]1>>Clc1ncc(Cl)c(Nc2cc(Cc3ccccc3)n[nH]2)n1,,CCO,,CCN(CC)CC,,val
US20090192203A1,COC(=O)COc1cc(Br)c(O)cc1C.N#CCCl>>COC(=O)COc1cc(Br)c(OCC#N)cc1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05378840,CCOC(=O)C(F)(F)C(O)c1ccccn1.NN>>NNC(=O)C(F)(F)C(O)c1ccccn1,,CCO,,O,O,val
US20080058378A1,Cl.O=C1CCOCC1.O=c1[nH]c2c(F)cc(C3CC3)cc2n1C1CCNCC1>>Cl.O=c1[nH]c2c(F)cc(C3CC3)cc2n1C1CCN(C2CCOCC2)CC1,,ClCCCl,,CCN(CC)CC,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20030195200A1,CCOC(=O)[C@H](Cc1ccc(O)cc1)OCC.OC/C=C/c1ccc2ccccc2c1>>CCOC(=O)[C@H](Cc1ccc(OC/C=C/c2ccc3ccccc3c2)cc1)OCC,,c1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20040138277A1,CCOC(=O)C(C)(Cc1ccc(OCc2ccccc2)cc1)Oc1ccc(OC(F)(F)F)cc1>>CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccc(OC(F)(F)F)cc1,[Pd],CCOC(C)=O,,,,val
US20070249688A1,COC(=O)c1ccc(C(CC(C)C)Oc2ccc(-c3ccc(C(C)(C)C)cc3)cc2)cc1>>CC(C)CC(Oc1ccc(-c2ccc(C(C)(C)C)cc2)cc1)c1ccc(C(=O)O)cc1,,CCO,,[Na+].[OH-],,val
US20120010191A1,C=O.Cn1cc(Br)cc(Nc2cc(C3CNC3)[nH]n2)c1=O>>CN1CC(c2cc(Nc3cc(Br)cn(C)c3=O)n[nH]2)C1,,CC(=O)O,CO,[Na+].[OH-],,val
US20160046648A1,CC(C)(C)OC(=O)N1C[C@H](O)C[C@@H]1C(=O)N1CCC(c2ccccc2C(C)(C)C)CC1>>CC(C)(C)c1ccccc1C1CCN(C(=O)[C@H]2C[C@@H](O)CN2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04360674,CCCCN.COc1c([N+](=O)[O-])cc(Br)c2ccccc12>>CCCCNc1c([N+](=O)[O-])cc(Br)c2ccccc12,,CO,,,,val
US20060160876A1,CCOC(=O)CCc1cc(C(C)C)c2[nH]c3c(c2c1)CCOC3(CC)CCO>>CCC1(CCO)OCCc2c1[nH]c1c(C(C)C)cc(CCCO)cc21,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050032790A1,COc1cc2c(ccn2S(C)(=O)=O)cc1F>>CS(=O)(=O)n1ccc2cc(F)c(O)cc21,,ClCCl,,BrB(Br)Br,,val
US06410556B1,CCOC(=O)c1c(CBr)cccc1O[Si](C)(C)C(C)(C)C.COc1ccc(CN2Cc3sc(N)c(C(=O)OC(C)(C)C)c3CC2CN)cc1>>COc1ccc(CN2Cc3sc(N)c(C(=O)OC(C)(C)C)c3CC2CN2Cc3cccc(O[Si](C)(C)C(C)(C)C)c3C2=O)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20040171606A1,CC(=O)N1CCc2ccccc2CC1.O=S(=O)(O)Cl>>CC(=O)N1CCc2ccc(S(=O)(=O)Cl)cc2CC1,,ClCCl,,,,val
US08399481B2,CCN1CC(C)(C)c2ccc([N+](=O)[O-])cc2C1=O>>CCN1CC(C)(C)c2ccc(N)cc2C1=O,[Pd],CN(C)C=O,,O=C[O-].[NH4+],,val
US20070275968A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(Br)c2)n1>>Cc1cccc(-c2nc(C(C)C)[nH]c2-c2cccc(B3OC(C)(C)C(C)(C)O3)c2)n1,,CCOC(C)=O,CN(C)C=O,CC(=O)[O-].[K+],,val
US20080255150A1,COC(=O)CCc1ccc(Cl)cc1CO.CS(=O)(=O)Cl>>COC(=O)CCc1ccc(Cl)cc1CCl,,ClCCl,,CCN(CC)CC,O,val
US20150284395A1,CCOC(=O)CC(=O)c1ccc(Cl)c(OCC)c1.Cc1cnc(-c2cn[nH]c2N)o1>>CCOc1cc(-c2cc(=O)n3ncc(-c4ncc(C)o4)c3[nH]2)ccc1Cl,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20040077605A1,C[Mg]Br.Cc1cc([N+](=O)[O-])cnc1C#N>>Cc1c([N+](=O)[O-])cnc(C#N)c1C,,C1CCOC1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20120010228A1,CC(C)(C)OC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCNCC3)C2=O)c1.O=C(CCCCl)c1ccccc1>>CC(C)(C)OC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCN(CCCC(=O)c4ccccc4)CC3)C2=O)c1,,CCC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20120258982A1,COS(=O)(=O)OC.Cc1ccc(C(=O)O)cc1F>>COC(=O)c1ccc(C)c(F)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20030195230A1,Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1.O=C(O)c1cccnc1Nc1ccc2cn[nH]c2c1>>O=C(Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1)c1cccnc1Nc1ccc2cn[nH]c2c1,,CN(C)C=O,ClCCl,ClCCCl,On1nnc2ccccc21,val
US05688815,CC(=O)OCCn1ccc(=O)c(OCc2ccccc2)c1CC(OC(C)=O)c1ccccc1>>CC(=O)OCCn1ccc(=O)c(O)c1Cc1ccccc1,[Pd],C1CCOC1,,,,val
US20020052376A1,CC(C)(C)[Si](OCc1nccn1CC(=O)c1ccc(F)cc1)(c1ccccc1)c1ccccc1>>CC(C)(C)[Si](OCc1nccn1CC(O)c1ccc(F)cc1)(c1ccccc1)c1ccccc1,,CO,,Cl,[BH4-].[Na+],val
US05665718,BrCc1ccccc1CBr.NCc1noc(-c2ncn3c2[C@@H]2CCN2C(=O)c2c(Cl)cccc2-3)n1>>O=C1c2c(Cl)cccc2-n2cnc(-c3nc(CN4Cc5ccccc5C4)no3)c2[C@@H]2CCN12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04526891,CS(=O)(=O)OCCc1ccc2c(c1)C(=O)c1ccccc1CO2.OC1(c2ccc(Cl)cc2)CCNCC1>>O=C1c2ccccc2COc2ccc(CCN3CCC(O)(c4ccc(Cl)cc4)CC3)cc21,,CCO,CCOCC,CO,O=C([O-])[O-].[K+].[K+],val
US06200981B1,CSc1nc(=S)n(Cc2cccc(C(=O)OC(C)(C)C)c2)cc1C1c2ccccc2C=Cc2ccccc21.O=C(O)C(F)(F)F>>O=C(O)c1cccc(Cn2cc(C3c4ccccc4C=Cc4ccccc43)c(=O)[nH]c2=S)c1,,ClCCl,,,,val
US20100168113A1,COc1cc(-c2ccnc(-c3cccnc3C(F)(F)F)n2)cc([N+](=O)[O-])c1OC>>O=[N+]([O-])c1cc(-c2ccnc(-c3cccnc3C(F)(F)F)n2)cc(O)c1O,,Br,,,,val
US20080139639A1,CN(Cc1cc(Br)n(S(=O)(=O)c2cccnc2)c1)C(=O)OC(C)(C)C.OB(O)c1ccc(F)cc1F>>CN(Cc1c[nH]c(-c2ccc(F)cc2F)c1)C(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20060229254A1,CCN(CC)CC.COC(=O)[C@@H]1CC[C@H](C(C)(C)C)N1.O=C=NCc1ccccc1>>CC(C)(C)[C@H]1CC[C@@H](C(=O)N2CCCC2)N1C(=O)NCc1ccccc1,,CN(C)C=O,,O=C(O)C(F)(F)F,,val
US20030203852A1,CCCCCCCCCCC[C@H](CC(=O)N[C@@H](CO)CCCNC(=O)OCc1ccccc1)OCc1ccccc1.ClCOCc1ccccc1>>CCCCCCCCCCC[C@H](CC(=O)N[C@H](CCCN)COCOCc1ccccc1)OCc1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05352381,C=C(Cl)c1ccc(CCC)cc1>>C#Cc1ccc(CCC)cc1,,O,,CC(C)(C)O,CC(C)(C)[O-].[K+],val
US20090209536A1,CCNCC.CN1CCN(c2nc(-c3ccccc3Cl)nc3ccc(C(=O)O)cc23)CC1>>CCN(CC)C(=O)c1ccc2nc(-c3ccccc3Cl)nc(N3CCN(C)CC3)c2c1,,CN(C)C=O,,On1nnc2ccccc21,,val
US20040254372A1,O=c1ncn2c3ccccc3c(=O)c3cccc1c32>>O=C1NCn2c3ccccc3c(=O)c3cccc1c32,,O,,,,val
US20070155839A1,COC(=O)c1ccc(C(=O)Cl)cc1.COc1ccccc1F>>COC(=O)c1ccc(C(=O)c2ccc(OC)c(F)c2)cc1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20160222033A1,CI.Cc1sc2nc(Cn3nc(C(F)(F)F)cc3C3CC3)cc(=O)n2c1C1CC1CO[Si](C)(C)C(C)(C)C>>Cc1sc2nc(C(C)n3nc(C(F)(F)F)cc3C3CC3)cc(=O)n2c1[C@@H]1C[C@H]1CO[Si](C)(C)C(C)(C)C,,C1CCOC1,,[Li]CCCC,,val
US20060089394A1,CNOC.O=C(O)c1cccc(Br)n1>>CON(C)C(=O)c1cccc(Br)n1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20120149677A1,O=[N+]([O-])c1ccc2c(c1)nnn2CC1CCC1>>Nc1ccc2c(c1)nnn2CC1CCC1,[Pd],CCO,,,,val
US20080039462A1,O=Cc1c[nH]c2ncccc12.O=S(=O)(Cl)c1ccccc1>>O=Cc1cn(S(=O)(=O)c2ccccc2)c2ncccc12,,C1CCOC1,,[H-].[Na+],,val
US20070161673A1,CNN.Cc1c(F)cc(C(=O)Nc2ccnn2C)cc1-c1cc(Cl)c(C(=O)c2ccc(F)cc2)cn1>>Cc1c(F)cc(C(=O)Nc2ccnn2C)cc1-c1cc2c(cn1)c(-c1ccc(F)cc1)nn2C,,C1CCOC1,O,,,val
US20090192153A1,COC(=O)CC1CCN(C(=O)OC(C)(C)C)CC1.Cl>>COC(=O)CC1CCNCC1.Cl,,C1COCCO1,Cl,,,val
US20100137313A1,COc1cc(Nc2ncc(-c3cnc(OC)c(/C(N)=N\O)c3)c(-n3nc(C(F)(F)F)cc3C)n2)cc(OC)c1.O=C(n1ccnc1)n1ccnc1>>COc1cc(Nc2ncc(-c3cnc(OC)c(-c4noc(=O)[nH]4)c3)c(-n3nc(C(F)(F)F)cc3C)n2)cc(OC)c1,,C1COCCO1,,C1CCC2=NCCCN2CC1,,val
US20130274229A1,C=CCOC(=O)c1cc(NC(=O)OC(C)(C)C)ccc1OCC=C>>C=CCOc1ccc(NC(=O)OC(C)(C)C)cc1C(=O)O,,CO,,[Na+].[OH-],,val
US20020193596A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccc(C#N)cc1-c1ccccc1C>>COC(=O)c1ccc(CNC(=O)OC(C)(C)C)cc1-c1ccccc1C,[Pd],C1CCOC1,,,,val
US20150210677A1,NC1=C(O)C(=O)C(c2ccc(Cl)cc2)O1.O=S(=O)(Cl)Cc1ccccc1>>NC1=C(OS(=O)(=O)Cc2ccccc2)C(=O)C(c2ccc(Cl)cc2)O1,,C1CCOC1,,,,val
US04123464,CC(C)=CCOC(C=C(C)C)OCC=C(C)C>>CC(C)=CCCC(C)=CC=O,,Cc1ccccc1,,,,val
US20060137207A1,COc1cc(C=CC(=O)c2ccc(I)cc2O)cc(OC)c1OCc1ccccc1.OO>>COc1cc(-c2oc3cc(I)ccc3c(=O)c2O)cc(OC)c1OCc1ccccc1,,CO,,Cl,[Na+].[OH-],val
US20150284395A1,CS(C)=O.Cc1nn2c(=O)cc(-c3ccc4c(c3)OCO4)[nH]c2c1C#N>>Cc1nn2c(=O)cc(-c3ccc4c(c3)OCO4)[nH]c2c1C(N)=O,,CS(C)=O,,O,[Na+].[OH-],val
US05298520,CC(=O)CCl.Sc1ccc(Br)cc1>>CC(=O)CSc1ccc(Br)cc1,,O,,[Na+].[OH-],,val
US20110046121A1,Cc1nc(N)cc(Cl)n1.OB(O)c1cncnc1>>Cc1nc(N)cc(-c2cncnc2)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US05446137,CCOC(=O)C(F)(F)F.COc1ccc(C(OC[C@@]2(C=CCCCCCN=[N+]=[N-])O[C@@H](n3cc(C)c(=O)[nH]c3=O)C[C@@H]2O[SiH2]C(C)(C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1>>COc1ccc(C(OC[C@@]2(C=CCCCCCNC(=O)C(F)(F)F)O[C@@H](n3cc(C)c(=O)[nH]c3=O)C[C@@H]2O[SiH2]C(C)(C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1,,CO,ClCCl,CCN(CC)CC,,val
US04207234,N#CCCl.O=C(Cc1ccccc1)NC1CNC1=O>>N#CCN1CC(NC(=O)Cc2ccccc2)C1=O,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US04642316,NCCN.O=C1N=C([O-])NC1(c1ccccc1)c1ccccc1.[Na+]>>NCCN.O=C1N=C([O-])NC1(c1ccccc1)c1ccccc1.[Na+],,O,,,,val
US20150057312A1,N#Cc1cc2cc([N+](=O)[O-])ccc2nc1Cl.Nc1ccc(Oc2ccccc2)cc1>>N#Cc1cnc2ccc([N+](=O)[O-])cc2c1Nc1ccc(Oc2ccccc2)cc1,,CCO,,O,,val
US20100022598A1,CC(C)(Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(CC(O)(c2ccc(-c3ccc(F)cn3)cc2)C(F)F)n1)C(O)CO>>CC(C)(C=O)Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(CC(O)(c2ccc(-c3ccc(F)cn3)cc2)C(F)F)n1,,C1CCOC1,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20150290194A1,CC(C)(C)[Si](C)(C)Cl.COC(=O)c1cnc(Cl)nc1NCCOCCO>>COC(=O)c1cnc(Cl)nc1NCCOCCO[Si](C)(C)C(C)(C)C,,CN(C)C=O,O,c1c[nH]cn1,,val
US09090628B2,Cc1nc(-c2cn3c(n2)-c2ccc(-c4ccnn4C4CCCN(Cc5ccccc5)C4)cc2OCC3)n(C(C)C)n1>>Cc1nc(-c2cn3c(n2)-c2ccc(-c4ccnn4C4CCCNC4)cc2OCC3)n(C(C)C)n1,[Pd],CO,,C1COCCO1,Cl,val
US20040044057A1,c1c[nH]cn1.c1ccc([C@@H]2CO2)cc1>>O[C@H](Cc1ncc[nH]1)c1ccccc1,,CCO,,c1ccncc1,,val
US05552426,CN1CCNCC1.Cc1cccc(-c2nc3ccc(OCCCl)cc3n2Cc2ccccc2)c1>>Cc1cccc(-c2nc3ccc(OCCN4CCN(C)CC4)cc3n2Cc2ccccc2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20140066426A1,CCOC(=O)c1c(Br)c(C)c(C(F)(F)F)n1Cc1ccccc1>>Cc1c(Br)c(C(=O)O)n(Cc2ccccc2)c1C(F)(F)F,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20090163524A1,CC(C)(C)OC(=O)NC(CCO)c1ccc(Cl)cc1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)NC(CCOS(C)(=O)=O)c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20120083501A1,CN1C(=O)C2(N=C1N)c1cc(Br)ccc1OC1CC(F)CCC12.OB(O)c1cncc(Cl)c1>>CN1C(=O)C2(N=C1N)c1cc(-c3cncc(Cl)c3)ccc1OC1CC(F)CCC12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20150087639A1,CCBr.Oc1ccc(-c2nccs2)cc1>>CCOc1ccc(-c2nccs2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120165318A1,COC(=O)c1ccc2nc(-c3ccccc3)c(N3CCC[C@@H]3C(F)(F)F)nc2c1>>O=C(O)c1ccc2nc(-c3ccccc3)c(N3CCC[C@@H]3C(F)(F)F)nc2c1,,O,,CO,[Na+].[OH-],val
US20040157838A1,CCOC(=O)CC(C)=O.Nc1cc(-c2ccccc2Cl)n[nH]1>>Cc1cc(O)n2nc(-c3ccccc3Cl)cc2n1,,CC(=O)O,,,,val
US20050085483A1,CC(C)N1CC2N(C(=O)C(NC(=O)C3CCCN3C(=O)OCC3c4ccccc4-c4ccccc43)CN2S(=O)(=O)c2ccc(Cl)cc2Cl)C(Cc2ccc(Cl)cc2)C1=O>>CC(C)N1CC2N(C(=O)C(NC(=O)C3CCCN3)CN2S(=O)(=O)c2ccc(Cl)cc2Cl)C(Cc2ccc(Cl)cc2)C1=O,,ClCCl,,CCNCC,,val
US20080293742A1,COc1nccnc1N.O=S(=O)(Cl)c1cccc(Cl)c1F>>COc1nccnc1NS(=O)(=O)c1cccc(Cl)c1F,,CCOC(C)=O,,,,val
US06288061B1,COc1ccc(-c2[nH]c(-c3ccc([N+](=O)[O-])cc3)nc2C(=O)Nc2nccs2)cc1>>O=C(Nc1nccs1)c1nc(-c2ccc([N+](=O)[O-])cc2)[nH]c1-c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,O,val
US05378720,CCI.CCc1cc(OC)ccc1C(=O)N(CC)CC>>CCC(C)c1cc(OC)ccc1C(=O)N(CC)CC,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20070259898A1,CC(c1ccccc1)N(Cc1ccccc1)C(CC(=O)OC(C)(C)C)C1CCCCC1>>CC(c1ccccc1)N(Cc1ccccc1)C(CC(=O)O)C1CCCCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040127514A1,CC(Br)C(=O)C(C)(C)C.Cc1cn2c(N)c(Cl)cc(C(=O)NCC3CCN(C[C@@H](C)CO)CC3)c2n1>>Cc1cn2c(N)c(Cl)cc(C(=O)NCC3CCN(C(C)C(=O)C(C)(C)C)CC3)c2n1,,CN(C)C=O,,[I-].[K+],,val
US20090137580A1,CNc1c(C#CCOC)ncnc1Oc1ccc(N)c(Cl)c1>>COCc1cc2ncnc(Oc3ccc(N)c(Cl)c3)c2n1C,I[Cu]I,CN(C)C=O,,O,,val
US20140378455A1,COc1ccc2[nH]nc(C(=O)NCC3CCN(C(=O)OC(C)(C)C)CC3)c2c1.Cl>>COc1ccc2[nH]nc(C(=O)NCC3CCNCC3)c2c1.Cl,,CCOCC,CO,,,val
US20100298325A1,COCCOc1cccc(N)c1.Fc1ccc(Oc2ccc(Cl)nc2)cc1F>>COCCOc1cccc(Nc2ccc(Oc3ccc(F)c(F)c3)cn2)c1,,C1COCCO1,CCOC(C)=O,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20110294777A1,CN(C)c1cc(N)ccn1.O=C(O)[C@@H]1CC[C@@H]2CN1C(=O)N2OCc1ccccc1>>CN(C)c1cc(NC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)ccn1,,ClCCl,,CCN(CC)CC,C[n+]1ccccc1Cl.[I-],val
US05192775,NCC1CCN(c2nc3ccccc3s2)CC1>>NCC1CCN(c2nc3ccccc3s2)CC1,,[Na+],[OH-],Cl,,val
US20090099213A1,CC(C)(C)OC(=O)N1CCC(c2ccc(Cl)cc2)(c2ccc(Br)cc2)CC1.CC(C)OB(OC(C)C)OC(C)C>>OB(O)c1ccc(C2(c3ccc(Cl)cc3)CCNCC2)cc1,,C1CCOC1,,[Li]CCCC,,val
US05360811,C#CCCCCCCCCCC.CC(C)(C#N)N=NC(C)(C)C#N.CCCC[SnH](CCCC)CCCC>>CCCCCCCCCCC=C[Sn](CCCC)(CCCC)CCCC,CC(C)(C#N)N=NC(C)(C)C#N,,,,,val
US05952362,Cc1cn(S(C)(=O)=O)c2cc([N+](=O)[O-])ccc12>>Cc1cn(S(C)(=O)=O)c2cc(N)ccc12,O=[Pt],CCO,,,,val
US20120071489A1,COC(=O)COc1ccc(C(=O)N2CCN(c3ccc(Cl)cc3C(C)(C)C)CC2)nc1>>CC(C)(C)c1cc(Cl)ccc1N1CCN(C(=O)c2ccc(OCC(=O)O)cn2)CC1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20020019526A1,CNC1CCCCC1.Cc1cc2c(Cl)ncnc2[nH]1>>Cc1cc2c(N(C)C3CCCCC3)ncnc2[nH]1,,CCOC(C)=O,,,,val
US20070232615A1,CN1CCN(c2cccc3nc(C=O)cn23)CC1.COc1ccc([C@H](C)N[C@H]2CCCc3cccnc32)cc1>>COc1ccc([C@H](C)N(Cc2cn3c(N4CCN(C)CC4)cccc3n2)[C@H]2CCCc3cccnc32)cc1,,CC(Cl)Cl,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20110312941A1,COc1cccnc1N1CCC(C(=O)O)CC1.Cc1ccc2c(c1)-c1[nH]c(N3CCOCC3)nc1CCN2>>COc1cccnc1N1CCC(C(=O)N2CCc3nc(N4CCOCC4)[nH]c3-c3cc(C)ccc32)CC1,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20060135782A1,COc1cc2ncnc(Nc3nc4ccc(N)cc4s3)c2cc1OC.O=C=Nc1cccc(F)c1>>COc1cc2ncnc(Nc3nc4ccc(NC(=O)Nc5cccc(F)c5)cc4s3)c2cc1OC,,O,,,,val
US20100029707A1,CC(=O)Cl.CCc1nn2ccc3oc(C)cc3c2c1CCN>>CCc1nn2ccc3oc(C)cc3c2c1CCNC(C)=O,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US04456757,CN1CCNCC1.O=S(=O)(Cl)c1cccc2cnccc12>>CN1CCN(S(=O)(=O)c2cccc3cnccc23)CC1,,ClC(Cl)Cl,,O=C([O-])[O-].[K+].[K+],,val
US20080027099A1,CC(=O)OC(C)=O.COC(=O)c1ccc(OC)c(OC2CCCC2)c1N>>COC(=O)c1ccc(OC)c(OC2CCCC2)c1NC(C)=O,,O,,C1COCCO1,,val
US20070066820A1,COC(=O)CCN1CCC[C@H]1COc1ccc(Cc2ccccc2)cc1.Cl>>Cl.O=C(O)CCN1CCC[C@H]1COc1ccc(Cc2ccccc2)cc1,,C1COCCO1,,,,val
US20100160308A1,CCOC(=O)c1sc(-n2cnc3ccc(CN4CCN(C)CC4)cc32)nc1-c1cccc(Cl)c1>>CN1CCN(Cc2ccc3ncn(-c4nc(-c5cccc(Cl)c5)c(C(=O)O)s4)c3c2)CC1,,C1CCOC1,O,[Li+].[OH-],,val
US20060079687A1,COC(OC)c1cc(Oc2cccc(N)c2)ccc1[N+](=O)[O-].O=C(Cl)OCc1ccccc1>>COC(OC)c1cc(Oc2cccc(NC(=O)OCc3ccccc3)c2)ccc1[N+](=O)[O-],,ClCCl,,CC(C)OC(C)C,,val
US04283539,Cc1c(CC(=O)O)c2ccccc2c(=O)n1O>>Cc1[nH]c(=O)c2ccccc2c1CC(=O)O,,CCOC(C)=O,,ClP(Cl)Cl,,val
US20040127555A1,Nc1ccc2c(c1)OCO2.O=C=Nc1ccc2c(c1)OCO2>>O=C(Nc1ccc2c(c1)OCO2)Nc1ccc2c(c1)OCO2,,c1ccccc1,,,,val
US20120316151A1,N#CCCl.O=C(C1CC1)N1CC[C@@H](Cc2n[nH]c(=O)n2-c2ccc(-c3ccc4occc4c3)cc2)C1>>N#CCn1nc(C[C@@H]2CCN(C(=O)C3CC3)C2)n(-c2ccc(-c3ccc4occc4c3)cc2)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100254916A1,CI.Cc1noc(C)c1Cn1cc(N2C(=O)CNC2=O)cn1>>Cc1noc(C)c1Cn1cc(N2C(=O)CN(C)C2=O)cn1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04792628,Cc1ccc(O)c2c1CCC2N.Cl.O=[N+]([O-])O>>Cc1cc([N+](=O)[O-])c(O)c2c1CCC2N.Cl,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20160052898A1,Nc1cc([N+](=O)[O-])ccc1Br.O=C(Cl)CCl>>O=C(CCl)Nc1cc([N+](=O)[O-])ccc1Br,,ClCCl,,c1ccncc1,,val
US20100216814A1,CN1CCc2[nH]c3ccc(Cl)cc3c2C1.Cc1cc(C2(C)CO2)cc(C)n1>>Cc1cc(C(C)(O)Cn2c3c(c4cc(Cl)ccc42)CN(C)CC3)cc(C)n1,,CN(C)C=O,,[H-].[Na+],,val
US20010046975A1,CCN(C)C(=O)c1ccccc1NC(C)(C)C.CI>>CCN(C)C(=O)c1ccccc1N(C)C(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080306082A1,C=O.OCCCC1CCNCC1>>CN1CCC(CCCO)CC1,,CC#N,,CC(=O)O,[BH3-]C#N.[Na+],val
US05260451,CCCCCCc1cc(-c2ccccc2)c2n1CCC2.O=C1CCCC(=O)O1>>CCCCCCc1c(C(=O)CCCC(=O)O)c(-c2ccccc2)c2n1CCC2,,ClCCl,,,,val
US05364865,COc1ccc(C#N)cc1.NO>>COc1ccc(C(N)=NO)cc1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20050171087A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.O=C(N[C@@H]1CCCN2c3cc(Br)ccc3Oc3ccccc3[C@H]12)C(F)(F)F>>CC(=O)c1ccc2c(c1)N1CCC[C@@H](NC(=O)C(F)(F)F)[C@H]1c1ccccc1O2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,,Cl,,val
US20120142665A1,CC(C)(C)OC(=O)Nc1ccn2nc(Br)nc2c1>>Nc1ccn2nc(Br)nc2c1,,ClCCl,,Cl,,val
US20050143381A1,CC1OC1(C)C.O=c1[nH]nc2c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)cnn12>>CC(n1nc2c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)cnn2c1=O)C(C)(C)O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06218376B1,CCc1ccc2c(c1)C=Cc1sc(C)nc1C2c1cn(C)c(=O)[nH]c1=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCc1ccc2c(c1)C=Cc1sc(C)nc1C2c1cn(C)c(=O)[nH]c1=S,,C1COCCO1,,,,val
US04889858,O=S(Cl)Cl.OC1c2ccccc2COc2cc(F)ccc21>>Fc1ccc2c(c1)OCc1ccccc1C2Cl,,ClCCl,,,,val
US20070037840A1,CC(C)(C)C(=O)Cl.Cc1nc2c3c(ccc2n1C)C(=O)[C@H](O)[C@@H](c1ccccc1)N3>>Cc1nc2c3c(ccc2n1C)C(=O)[C@H](OC(=O)C(C)(C)C)[C@@H](c1ccccc1)N3,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040162279A1,CC1CN(c2ccc(Br)cc2C2OCCO2)CC(C)O1.CON(C)C(C)=O>>CC(=O)c1ccc(N2CC(C)OC(C)C2)c(C=O)c1,,C1CCOC1,,[Li]C(C)(C)C,,val
US20100234351A1,CC(C)(C)OC(=O)NOCCS(C)(=O)=O.Cl>>CS(=O)(=O)CCON.Cl,,CCO,,,,val
US20030119902A1,CCOP(=O)(CC(=O)NCc1ccccc1Nc1ccc(C(=O)c2ccccc2C)c(Cl)c1)OCC>>Cc1ccccc1C(=O)c1ccc(Nc2ccccc2CNC(=O)CP(=O)(O)O)cc1Cl,,ClCCl,,C[Si](C)(C)Br,,val
US20150087639A1,NCCN1CCOCC1.O=[N+]([O-])c1ccc(F)c(F)c1>>O=[N+]([O-])c1ccc(NCCN2CCOCC2)c(F)c1,,CCOC(C)=O,,CCN(CC)CC,,val
US05185352,CCCCCCCCCCCCCCCCCCBr.O=c1cc(CO)occ1O>>CCCCCCCCCCCCCCCCCCOc1coc(CO)cc1=O,,CN(C)C=O,O,[I-].[K+],,val
US20160046590A1,C=CCCC(=O)N[C@@H](CN(C)C(=O)[C@@H](CC=C)CC(=O)Cc1ccc(Cl)cc1)c1ccccc1>>CN1C[C@@H](c2ccccc2)NC(=O)CCC=CC[C@@H](CC(=O)Cc2ccc(Cl)cc2)C1=O,,CCOC(C)=O,Cc1ccccc1,,,val
US20150038574A1,CC1=C(CO)C(C)(C)CCC1.Cc1cccc(O)c1>>CC1=C(COc2cccc(C)c2)C(C)(C)CCC1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04296239,COC(=O)c1cc(Cl)ccc1-n1c(C)nnc1CCl.N>>Cc1nnc2n1-c1ccc(Cl)cc1C(=O)NC2,,C1CCOC1,CO,[I-].[K+],,val
US20100137354A1,CC1CC(C)CN(S(=O)(=O)c2ccc3c(c2)c(=S)c2cc(S(=O)(=O)N4CC(C)CC(C)C4)ccc2n3C)C1.NO>>CC1CC(C)CN(S(=O)(=O)c2ccc3c(c2)c(=NO)c2cc(S(=O)(=O)N4CC(C)CC(C)C4)ccc2n3C)C1,,c1ccncc1,,Cl,,val
US05646310,CCOC(=O)C1=CC(CF)(CF)Oc2ccc(C(F)(F)F)cc21>>O=C(O)C1=CC(CF)(CF)Oc2ccc(C(F)(F)F)cc21,,CCO,,Cl,[K+].[OH-],val
US05120831,C1CCOC1.CC(=O)O.NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1.NCCCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(N)=O>>CC(=O)CC(=O)CC(=O)O,[Pd],C1CCOC1,O,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20090163488A1,CCn1cc(C)c(C(=O)O)n1.Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)c1>>CCn1cc(C)c(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)n1,CN(C)C=O,CC(=O)N(C)C,,C1CCOC1,O=C(Cl)C(=O)Cl,val
US20160272621A1,C[Mg]Br.O=Cc1cc(F)ncc1Br>>CC(O)c1cc(F)ncc1Br,,C1CCOC1,,,,val
US20040048915A1,CCc1ccc2c(C(=O)C(=O)OC)c[nH]c2c1.Cn1ccc2cccc(CC(N)=O)c21>>CCc1ccc2c(C3=C(c4cccc5ccn(C)c45)C(=O)NC3=O)c[nH]c2c1,,CN(C)C=O,,C1CCOC1,CC(C)(C)[O-].[K+],val
US20120142714A1,CC(F)(F)CCO.CS(=O)(=O)Cl>>CC(F)(F)CCOS(C)(=O)=O,,C1CCOC1,,CCN(CC)CC,O,val
US20130005760A1,Cc1noc(C)c1-c1ccc2c(=O)cc(CO)n(-c3cc(NC(=O)OC(C)(C)C)c(F)cc3F)c2n1>>Cc1noc(C)c1-c1ccc2c(=O)cc(CO)n(-c3cc(N)c(F)cc3F)c2n1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20080021027A1,CC(C)CC(C(=O)NC1CCCCC1)N(C(=O)c1ccc(Cl)cc1)c1ccccc1NC(=O)OC(C)(C)C>>CC(C)CC(C(=O)NC1CCCCC1)n1c(-c2ccc(Cl)cc2)nc2ccccc21,,CO,,Cl,,val
US20140296183A1,CCOC(=O)C(CC(=O)c1ccc(OC)c(C(F)(F)F)c1)(NC(C)=O)C(=O)OCC>>CCOC(=O)C(CCc1ccc(OC)c(C(F)(F)F)c1)(NC(C)=O)C(=O)OCC,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20150307493A1,CN(C)S(=O)(=O)c1cc(Br)c(O)c([N+](=O)[O-])c1>>CN(C)S(=O)(=O)c1cc(N)c(O)c(Br)c1,[Ni],CCO,,,,val
US04933339,N#CCc1ccccc1.O=S(=O)([O-])CCCc1ccc(Cl)cc1>>N#CC(CCc1ccc(Cl)cc1)c1ccccc1,,CS(C)=O,O,Cc1ccccc1,[Na+].[OH-],val
US04594419,Nc1[nH]c(=O)[nH]c(=O)c1Br.Nc1ccccc1S>>Nc1ccccc1Sc1c(N)[nH]c(=O)[nH]c1=O,,OCCO,,O=C([O-])[O-].[K+].[K+],,val
US20080214549A1,CCOC(=O)c1c(O)c(C(C)C)nn(Cc2ccccc2[N+](=O)[O-])c1=O.CCOC(C)=O.O=[N+]([O-])c1ccccc1CBr>>CC(C)c1nn(Cc2ccccc2[N+](=O)[O-])c(=O)c(C(=O)NCC(=O)O)c1O,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20140235640A1,N#Cc1cc(C=O)cc([N+](=O)[O-])c1O.NC(N)=O.O=C(Cc1ccccc1)c1ccccc1>>N#Cc1cc(C2NC(=O)NC(c3ccccc3)=C2c2ccccc2)cc([N+](=O)[O-])c1O,,CCO,,Cl,,val
US20160185752A1,CN.COc1cc(C(F)(F)F)ccc1C1CCCN(C(=O)c2cnnc(Cl)c2)C1>>CNc1cc(C(=O)N2CCCC(c3ccc(C(F)(F)F)cc3OC)C2)cnn1,,C1CCOC1,,,,val
US20060211727A1,CC(C)(C)OC(=O)CCc1c(-c2ccccc2Cl)cc(Cl)nc1Cl>>COC(=O)CCc1c(-c2ccccc2Cl)cc(Cl)nc1Cl,,COc1ccccc1,,O=C(O)C(F)(F)F,,val
US20130172328A1,O=[N+]([O-])c1ccc(N2CCn3c2nc2cccnc23)cc1>>Nc1ccc(N2CCn3c2nc2cccnc23)cc1,[Pd],CO,,,,val
US04014919,CCC#CCC1C(=O)CCC1CC(=O)O.c1ccncc1>>CC/C=C\C[C@H]1C(=O)CC[C@@H]1CC(=O)OC,[Pd],,,,,val
US20080027067A1,Cc1cc(S(=O)(=O)Nc2nccs2)ccc1NC(=O)C(F)(F)F>>Cc1cc(S(=O)(=O)Nc2nccs2)ccc1N,,O,,Cl,[Na+].[OH-],val
US20110098325A1,II.Nc1ccc(Br)cn1>>Nc1ncc(Br)cc1I,,CS(C)=O,,,,val
US05552533,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)[C@@]3(O[C@]1(C)[C@H](O)[C@H]3C)O2.O=S(=O)(c1ccccc1)N(F)S(=O)(=O)c1ccccc1>>CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@](C)(F)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,,CC(=O)O,O,ClCCl,[Na+].[OH-],val
US05032577,O=C(O)CCCCC1C(=O)OCN1C(=O)OCc1ccccc1>>COC(=O)C(CCCCC(=O)O)NC(=O)OCc1ccccc1,,CO,,C[O-].[Na+],,val
US20120134934A1,CN1CC[C@@H](OC(=O)C(NC(=O)OC(C)(C)C)c2ccccc2)C1.O=C(CBr)c1ccccc1>>CC(C)(C)OC(=O)NC(C(=O)O[C@@H]1CC[N+](C)(CC(=O)c2ccccc2)C1)c1ccccc1.[Br-],,CC#N,CN(C)C=O,,,val
US20050288308A1,C=C(Cl)C#N.N=C(N)C1CC1>>Nc1ccnc(C2CC2)n1,,CCO,,CCN(CC)CC,Cl,val
US04044015,BrCc1ccccc1.c1ccn2ccnc2c1>>[Br-].c1ccc(C[n+]2ccn3ccccc32)cc1,,CC#N,,,,val
US20110039892A1,CC(O)c1cccc(S(C)(=O)=O)c1.O=C1NC(=O)c2ccccc21>>CC(c1cccc(S(C)(=O)=O)c1)N1C(=O)c2ccccc2C1=O,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150011548A1,C#Cc1cnc2c(c1)ncn2-c1cc(NC(C)=O)cc(-c2ccc(F)cc2F)c1.[N-]=[N+]=NC1CCOCC1>>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)cnc32)c1,I[Cu]I,CN(C)C=O,,,,val
US04966905,CC1=CC(=O)C(C)(C)O1.O=Cc1ccc(Cl)cc1Cl>>CC1(C)OC(C=Cc2ccc(Cl)cc2Cl)=CC1=O,,CCO,,[Na+].[OH-],,val
US20070010670A1,C1CCNC1.COc1ccc(S(=O)(=O)Cl)cc1[N+](=O)[O-]>>COc1ccc(S(=O)(=O)N2CCCC2)cc1[N+](=O)[O-],,c1ccncc1,,,,val
US20120245144A1,CC(C)=O.Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C)c4C4CCCNC4)cc2OCC3)n(C(C)C)n1>>Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C)c4C4CCCN(C(C)C)C4)cc2OCC3)n(C(C)C)n1,,CCO,,[BH3-]C#N.[Na+],,val
US20080015278A1,O=C1OC(=O)[C@@H]2C3C=CC(C3)[C@H]12.O=C1O[C@H]([C@@H](O)CO)C(O)=C1O>>O=C1O[C@H]([C@@H](O)COC(=O)C2C3C=CC(C3)C2C(=O)O)C(O)=C1O,CN(C)c1ccncc1,CC(C)=O,,O,,val
US20030144282A1,CC(C)O.COC(=O)c1ccc(OC(C)=O)cc1O>>COC(=O)c1ccc(OC(C)=O)cc1OC(C)C,,ClCCl,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120071461A1,Brc1ccncc1.CN(C(=O)OCc1ccccc1)C1CCCNC1>>CN(C(=O)OCc1ccccc1)C1CCCN(c2ccncc2)C1,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20030069297A1,Cc1cc(C(=O)NCCn2ccnn2)c(C=O)[nH]1.O=C1Cc2c(cccc2-c2ccc(F)c(Cl)c2)N1>>Cc1cc(C(=O)NCCn2ccnn2)c(C=C2C(=O)Nc3cccc(-c4ccc(F)c(Cl)c4)c32)[nH]1,C1CCNCC1,CCO,,,,val
US04640929,CCOC(=O)CC(=O)OCC.CN(C)C(CSS(=O)(=O)c1ccccc1)CSS(=O)(=O)c1ccccc1>>CCOC(=O)C1(C(=O)OCC)SCC(N(C)C)CS1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20060014746A1,CC(C)(O)CCO.CCc1c(Cn2ccnc2-c2nccs2)nc2ccc(Cl)nn12>>CCc1c(Cn2ccnc2-c2nccs2)nc2ccc(OCCC(C)(C)O)nn12,,C1CCOC1,,CC(C)(C)O[K],,val
US06992094B1,CCOC(=O)CCCBr.CCOC(=O)c1ccc([Se]c2cc3c(cc2O)C(C)(C)CCC3(C)C)cc1>>CCOC(=O)CCCOc1cc2c(cc1[Se]c1ccc(C(=O)OCC)cc1)C(C)(C)CCC2(C)C,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20070027248A1,O.Oc1cccc(O)c1.Oc1ccccc1>>Oc1cc(O)cc(O)c1.Oc1ccccc1,,O,,,,val
US05292760,CNC(Cc1ccccc1NC(=O)C(C)(C)C)c1cccnc1>>CNC(Cc1ccccc1N)c1cccnc1,,Cl,,,,val
US20150284395A1,CCc1noc2cc(C(=O)OC)ccc12>>CCc1noc2cc(C(=O)O)ccc12,,CO,O,[Na+].[OH-],,val
US04665080,CCCCCOCC(=O)CP(=O)(OC)OC.O=Cc1ccc(Cc2ncc[nH]2)cc1>>CCCCCOCC(=O)/C=C/c1ccc(Cc2ncc[nH]2)cc1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20070003680A1,CC(C)CNC(=O)C(C)(C)c1ccc(-c2cncc(CO)n2)cc1.CI>>COCc1cncc(-c2ccc(C(C)(C)C(=O)NCC(C)C)cc2)n1,,CS(C)=O,,[K+].[OH-],,val
US20030220324A1,CC(C)(C)OC(=O)N1CCN(c2ccccc2[N+](=O)[O-])CC1>>CC(C)(C)OC(=O)N1CCN(c2ccccc2N)CC1,[Pd],CCO,,,,val
US05216007,Clc1ccc(C(c2ccc(Cl)cc2)C(Cl)Cl)cc1>>ClC=C(c1ccc(Cl)cc1)c1ccc(Cl)cc1,,CS(C)=O,,[Na+].[OH-],,val
US06677473B1,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1cc(I)c(O)c(I)c1>>COC(=O)C=Cc1cc(I)c(O)c(I)c1,,c1ccccc1,,,,val
US20110003790A1,CC(C)(C)OC(=O)c1c(Cl)nc(Cl)c(C(=O)O)c1N>>Nc1c(C(=O)O)c(Cl)nc(Cl)c1C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120245161A1,COCCBr.Clc1cccc2[nH]ccc12>>COCCn1ccc2c(Cl)cccc21,,CN(C)C=O,,[H-].[Na+],,val
US20100331397A1,CC(C)(C)[Si](C)(C)Cl.CO[C@@H]1[C@@H](CO)O[C@@H](n2cnc3c(N)ncnc32)[C@@H]1O>>CO[C@@H]1[C@@H](CO[Si](C)(C)C(C)(C)C)O[C@@H](n2cnc3c(N)ncnc32)[C@@H]1O,,CO,c1ccncc1,,,val
US20060116364A1,COc1ccc(-c2ccc3cc(OC)ccc3c2)c([N+](=O)[O-])c1>>COc1ccc(-c2ccc3cc(OC)ccc3c2)c(N)c1,[Pd],C1CCOC1,CO,,,val
US20040106653A1,C[C@H](Cc1ccc(S(=O)(=O)c2ccc(F)cc2C(=O)O)cc1)N(C[C@H](O[Si](C)(C)C(C)(C)C)c1cccc(Cl)c1)C(=O)OC(C)(C)C.C[S-]>>CSc1ccc(S(=O)(=O)c2ccc(C[C@@H](C)N(C[C@H](O)c3cccc(Cl)c3)C(=O)OC(C)(C)C)cc2)c(C(=O)O)c1,,CN(C)C=O,,Cl,,val
US06011077,CC(C)(O)C(=O)c1ccc(O)cc1.COC(CCl)OC>>COC(COc1ccc(C(=O)C(C)(C)O)cc1)OC,,CO,,[Na+].[OH-],,val
US20110201625A1,BrC(Br)(Br)Br.COC(=O)COc1ccc(CCCO)cc1>>COC(=O)COc1ccc(CCCBr)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20140221333A1,CC1(C)OB(c2ccc(C#N)cc2F)OC1(C)C.COc1ccc(CNc2nccn3c([C@@H]4CCCN(C(=O)OCc5ccccc5)C4)nc(Br)c23)c(OC)c1>>COc1ccc(CNc2nccn3c([C@@H]4CCCN(C(=O)OCc5ccccc5)C4)nc(-c4ccc(C#N)cc4F)c23)c(OC)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20140194431A1,CC(C)(C)[Si](C)(C)OCCNC1CCOCC1.O=C(O)c1nc(CC2(c3ccccc3)CCCC2)nc(O)c1OCc1ccccc1>>CC(C)(C)[Si](C)(C)OCCN(C(=O)c1nc(CC2(c3ccccc3)CCCC2)nc(O)c1OCc1ccccc1)C1CCOCC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140031360A1,CC(C)Oc1cncc(-c2ccc3[nH]cc(-c4cncc(N[C@@H]5CCCN(C(=O)OC(C)(C)C)C5)n4)c3c2)n1>>CC(C)Oc1cncc(-c2ccc3[nH]cc(-c4cncc(N[C@@H]5CCCNC5)n4)c3c2)n1,,CCOC(C)=O,,Cl,,val
US20080318947A1,C=Cc1cc2c(nc(-c3nonc3N)n2CC)c(Cl)n1.O=[O+][O-]>>CCn1c(-c2nonc2N)nc2c(Cl)nc(CO)cc21,,ClCCl,,[BH4-].[Na+],,val
US05591881,CCC(CC)(O[PH](=O)[O-])Sc1ccc(C)cc1.C[C@H](C=O)O[Si](C)(C)C(C)(C)C>>Cc1ccc(S/C=C/[C@@H](C)O[Si](C)(C)C(C)(C)C)cc1,,C1CCOC1,,[Li]CCCC,,val
US20050009841A1,Clc1cccnc1Br.O=C(O)C1=CCNCC1>>O=C(O)C1=CCN(c2ncccc2Cl)CC1,,CS(C)=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20060160865A1,CN(C(=O)Oc1ccc(N)cn1)c1ccccc1.N#Cc1ccc(C(=O)Cl)cc1>>CN(C(=O)Oc1ccc(NC(=O)c2ccc(C#N)cc2)cn1)c1ccccc1,,CC#N,,CCN(CC)CC,ClCCl,val
US20130172316A1,CC(=O)OC(C)=O.CC(N)Cc1ccc(Br)cc1>>CC(=O)NC(C)Cc1ccc(Br)cc1,,CC(=O)O,,,,val
US20100317608A1,O=C(O)CCCC[C@@H]1CCSS1.O=C1CCC(=O)N1O>>NC(=O)CCCC[C@@H]1CCSS1,,CCOC(C)=O,ClCCl,ClCCCl,,val
US20090163714A1,N#CN1CCCCC1.NO>>N=C(NO)N1CCCCC1,,CO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US05618821,C#CCO.CC(=O)c1cccc(Br)n1>>CC(=O)c1cccc(CC#CO)n1,[Cu]I,CCN(CC)CC,O,,,val
US20090275570A1,BrCc1nc2ccccc2s1.CC1(C)OB(c2cn[nH]c2)OC1(C)C>>CC1(C)OB(c2cnn(Cc3nc4ccccc4s3)c2)OC1(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20100240139A1,COC(=O)c1ccccc1CON1C(C)(C)CCCC1(C)C>>CC1(C)CCCC(C)(C)N1OCc1ccccc1C(=O)O,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20010027196A1,C=Cc1c(SC)nc(N)nc1-c1ccco1>>CCc1c(SC)nc(N)nc1-c1ccco1,[Pd],CCO,,[H][H],,val
US20100144756A1,Cc1nn(C(=O)OC(C)(C)C)cc1C#N.NO>>Cc1nn(C(=O)OC(C)(C)C)cc1C(N)=NO,,CCO,,O,,val
US20050187236A1,CC(C)(O)C(=O)N1CCN(NC(=O)OCc2ccccc2)CC1>>CC(C)(O)C(=O)N1CCNCC1,[Pd],CO,,,,val
US04589905,CNC(=O)c1cnn(-c2ccccc2)c1C#N.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CNC(=S)c1cnn(-c2ccccc2)c1C#N,,Cc1ccccc1,,,,val
US20150274657A1,CC1(C(=O)O)CCNC1.O=Cc1csc(-c2ccccc2)n1>>CC1(C(=O)O)CCN(Cc2csc(-c3ccccc3)n2)C1,,ClCCCl,ClCCl,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04198348,CCCCCCCCC(N)=O.ClCl>>CCCCCCCCC(=O)NCl,,O,,,,val
US04874775,CS(=O)(=O)Cl.N#Cc1ccc(NCc2cccnc2)cc1>>CS(=O)(=O)N(Cc1cccnc1)c1ccc(C#N)cc1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US05869485,Cc1cc(-c2cn(-c3cccc(OCCCl)c3)c3ncnc(N)c23)ccc1OCc1ccccc1.[Na]c1ncc[nH]1>>Cc1cc(-c2cn(-c3cccc(OCCn4ccnc4)c3)c3ncnc(N)c23)ccc1OCc1ccccc1,,CN(C)C=O,,,,val
US20030187261A1,Clc1ncnc2nc[nH]c12.NC(CO)c1ccccc1>>OCC(Nc1ncnc2nc[nH]c12)c1ccccc1,,CCCCO,,CCN(CC)CC,,val
US20040248854A1,CC(C)I.O=C(O)CCCC#CCN1C(=O)CCC[C@@H]1/C=C/C(O)Cc1ccccc1>>CC(C)OC(=O)CCCC#CCN1C(=O)CCC[C@@H]1/C=C/C(O)Cc1ccccc1,,CC(C)=O,CCOC(C)=O,C1CCC2=NCCCN2CC1,,val
US07271262B2,CC(C)(C)OC(=O)N1CCC(n2cc(C(=O)c3cccc(N)c3)c3c(N)ncnc32)CC1.O=S(=O)(Cl)c1cc(Cl)cc(Cl)c1>>CC(C)(C)OC(=O)N1CCC(n2cc(C(=O)c3cccc(NS(=O)(=O)c4cc(Cl)cc(Cl)c4)c3)c3c(N)ncnc32)CC1,,c1ccncc1,,,,val
US20090215759A1,CCOC(C)=O.COc1cc(Nc2nc(C)cc(N(C)CC(=O)OCc3ccccc3)n2)ccc1-n1cnc(C)c1.C[Mg]Cl>>COc1cc(Nc2nc(C)cc(N(C)CC(C)(C)O)n2)ccc1-n1cnc(C)c1,,C1CCOC1,,,,val
US20160222033A1,COc1cnc(N2C(=O)c3ccccc3C2=O)s1.O=C1CCC(=O)N1Cl>>COc1sc(N2C(=O)c3ccccc3C2=O)nc1Cl,,CC#N,,,,val
US20040110807A1,CN(C)C=O.Fc1cc(OCc2ccccc2)ccc1Br>>O=Cc1ccc(OCc2ccccc2)cc1F,,C1CCOC1,,[Li]CCCC,,val
US20050267104A1,CC(C)(C)C(=O)OCOC(=O)Cl.NC[C@H]1CN(c2ccc(C3CCS(=O)(=O)CC3)c(F)c2)C(=O)O1>>CC(C)(C)C(=O)OCOC(=O)NC[C@H]1CN(c2ccc(C3CCS(=O)(=O)CC3)c(F)c2)C(=O)O1,,ClCCl,,,,val
US20110092547A1,CCOC(=O)C1(C)CCC(Oc2ccc(NC(=O)C(=O)NN)cn2)CC1.Fc1ccc(N=C=S)cc1F>>CCOC(=O)C1(C)CCC(Oc2ccc(NC(=O)c3nnc(Nc4ccc(F)c(F)c4)o3)cn2)CC1,,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20100124550A1,CC(C)[C@H](C/C=C/CBr)C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1.COCCCOc1cc(C(=O)CC(C)C)ccc1OC>>COCCCOc1cc(C(=O)C(C/C=C/C[C@H](C(=O)N2C(=O)OC[C@@H]2Cc2ccccc2)C(C)C)C(C)C)ccc1OC,,C1CCOC1,CCOC(C)=O,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20110009417A1,O=P(Br)(Br)Br.O=c1c(O)nc2cccnc2n1CC1CC1>>O=c1c(Br)nc2cccnc2n1CC1CC1,,CC(Cl)Cl,,O=C([O-])[O-].[Na+].[Na+],,val
US04421927,COc1ccc(C(C)=O)cc1C=CC(=O)O.O=Cc1ccccc1>>COc1ccc(C(=O)C=Cc2ccccc2)cc1C=CC(=O)O,,[Na+],[OH-],,,val
US20080090883A1,N#Cc1ccc(N2C[C@H]3[C@H]4C=C[C@H](C4)[C@@]3(COCc3ccccc3)S2(=O)=O)cc1C(F)(F)F>>N#Cc1ccc(N2C[C@H]3[C@H]4CC[C@H](C4)[C@@]3(CO)S2(=O)=O)cc1C(F)(F)F,[Pd],CCOC(C)=O,CO,[H][H],,val
US20130216498A1,N#Cc1ccc(Cl)nc1.N#Cc1ccc2ncc(-c3nccc(N[C@@H]4CCCNC4)n3)n2c1>>N#Cc1ccc(N2CCC[C@@H](Nc3ccnc(-c4cnc5ccc(C#N)cn45)n3)C2)nc1,,Cl,ClCCl,CCN(CC)CC,,val
US04672137,CCOC(=O)NC(C)CC(NC(=O)OCC)NC(=O)OCC>>CCOC(=O)NCCC(C)NC(=O)OCC,[Ni],CCO,,[H][H],,val
US20080280875A1,C=CCOc1cc(C(=O)OC)cc(C(=O)OC)c1>>C=CCc1c(O)cc(C(=O)OC)cc1C(=O)OC,,CCOC(C)=O,,CN(C)c1ccccc1,,val
US20110124601A1,CC(NC(=O)C(Cc1ccc(Br)cc1)CP(=O)(O)C(C)NC(=O)OCc1ccccc1)C(=O)OC(C)(C)C>>CC(NC(=O)C(Cc1ccc(Br)cc1)CP(=O)(O)C(C)N)C(=O)O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20110136763A1,CCc1cc(OC2CCCCO2)cc(O)c1C=O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCc1cc(OC2CCCCO2)cc(OS(=O)(=O)C(F)(F)F)c1C=O,,ClCCl,O,CCN(CC)CC,,val
US20080161559A1,N#Cc1c(O)cccc1F.O=C1c2ccccc2C(=O)N1CCCBr>>N#Cc1c(F)cccc1OCCCN1C(=O)c2ccccc2C1=O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20080293775A1,CCOC(=O)Cc1ccc(Cl)c(Oc2ccc(S(C)(=O)=O)cc2Cl)c1>>CS(=O)(=O)c1ccc(Oc2cc(CC(=O)O)ccc2Cl)c(Cl)c1,,C1CCOC1,O,[Na+].[OH-],,val
US20070219187A1,N#Cc1ccc(F)cc1F.NO>>N=C(NO)c1ccc(F)cc1F,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20060148858A1,CCc1cnc(Cl)nc1.COCOCCCc1c[nH]nc1C(C)C>>CCc1cnc(-n2cc(CCCO)c(C(C)C)n2)nc1,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US20040197358A1,CCCCCCBr.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-],,Cc1ccccc1,,,,val
US20150126523A1,NO.O=Cc1ccc(Br)c(CC(F)(F)F)c1>>ON=Cc1ccc(Br)c(CC(F)(F)F)c1,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20080070976A1,COC(=O)c1ccc(C(=O)NC(C)c2ccc([N+](=O)[O-])cc2)s1>>COC(=O)c1ccc(C(=O)NC(C)c2ccc(N)cc2)s1,[Pd],C1CCOC1,,CO,,val
US08076310B2,CC(=O)Nc1ccn(C2(O)OC[C@H](OCP(=O)(OC(C)C)OC(C)C)[C@H]2OC(=O)c2ccccc2)c(=O)n1>>CC(C)OP(=O)(CO[C@H]1COC(O)(n2ccc(N)nc2=O)[C@@H]1O)OC(C)C,,CO,,N,,val
US20150329538A1,CC(C)(C)N.Cc1nc2ccnc(Cl)c2nc1Cl>>Cc1nc2ccnc(Cl)c2nc1NC(C)(C)C,,CN1CCCC1=O,O,,,val
US05348958,COCc1c(C(=O)OC(C)C)ncc2[nH]c3ccc(Oc4nccc5ccccc45)cc3c12>>COCc1c(C=O)ncc2[nH]c3ccc(Oc4nccc5ccccc45)cc3c12,,Cc1ccccc1,,CCN(CC)CC,C[Si](C)(C)Cl,val
US06777406B2,CCOC(=O)[C@@]12CN(Cc3ccccc3)C[C@@H]1c1cccc3c1N(CCCO3)C2=O>>O=C1[C@@H]2CN(Cc3ccccc3)C[C@@H]2c2cccc3c2N1CCCO3,,C1COCCO1,,Cl,,val
US20020147214A1,CCCC[Sn](Cl)(CCCC)CCCC.CN(C)CCCn1ccnc1>>CCCC[Sn](CCCC)(CCCC)c1cncn1CCCN(C)C,,CCCCCC,,CN(C)CCN(C)C,[Li]CCCC,val
US20040053908A1,COCCOc1cc2nccc(Oc3ccc(N)cc3)c2cc1C#N.Cc1cc(NC(=O)Oc2ccccc2)no1>>COCCOc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)cc3)c2cc1C#N,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US20130281433A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccnc(-c4ccc5[nH]ncc5c4)c3)sc2c1-c1ccc(Cl)cc1.COC(=O)C(F)(F)Cl>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccnc(-c4ccc5c(cnn5C(F)F)c4)c3)sc2c1-c1ccc(Cl)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060172973A1,CCOC(=CC(=O)C(=O)OC)c1ncnc2c1ncn2Cc1ccccc1>>COC(=O)C(O)=CC(=O)c1ncnc2c1ncn2Cc1ccccc1,,ClCCl,,,,val
US04367238,COS(=O)(=O)OC.Cc1cccc(Oc2ccccc2F)c1O>>COc1c(C)cccc1Oc1ccccc1F,,[K+],[OH-],,,val
US20060287343A1,CN=C=O.O=C(Cc1ccccc1)NC(=S)Nc1ccc(Oc2ccnc3cc(-c4ccc(CN5CCNCC5)cc4)sc23)c(F)c1>>CNC(=O)N1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc(NC(=S)NC(=O)Cc6ccccc6)cc5F)c4s3)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20040106657A1,CCOC(=O)C(Cc1cccc2[nH]ccc12)OCC.Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1CCl>>CCOC(=O)C(Cc1cccc2c1ccn2Cc1nc(-c2ccc(C(F)(F)F)cc2)oc1C)OCC,,CN(C)C=O,,[H-].[Na+],,val
US20090291079A1,Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1.Nc1ccncc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US05656644,N#Cc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1.NO>>NC(=NO)c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1,,CCO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20060040957A1,ClCc1ccc(Cl)cc1.O=c1cc2sccn2c(=O)[nH]1>>O=c1cc2sccn2c(=O)n1Cc1ccc(Cl)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05474994,CCOC(=O)c1cccc2c(=O)cc(-c3ccccc3)oc12.COc1ccc(P2SP(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)c1cccc2c(=S)cc(-c3ccccc3)oc12,,Cc1ccccc1,,,,val
US20100113440A1,COC(=O)C1CC(O)CC1C(=O)OC>>O=C(O)C1CC2CC1C(=O)O2,,CO,,Cl,[Na+].[OH-],val
US05530141,C=CCBr.COc1cc([C@@H]2SC[C@@H](c3cc(OC)c(OC)c(OC)c3)S2)cc([N+](=O)[O-])c1O>>C=CCOc1c(OC)cc([C@@H]2SC[C@@H](c3cc(OC)c(OC)c(OC)c3)S2)cc1[N+](=O)[O-],,CN(C)C=O,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US07875735B2,COc1ccc(C2=Cc3ccc(OCc4ccccc4)cc3OC2)cc1>>COc1ccc(C2=Cc3ccc(O)cc3OC2)cc1,,ClCCl,,ClB(Cl)Cl,,val
US20050261294A1,CCOC(=O)c1cccc(C)n1.O=C1CCC(=O)N1Br>>CCOC(=O)c1cccc(CBr)n1,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US05239075,C=CC(N)=O.CC1C(=O)CCc2cc(F)ccc21>>CC12CCC(=O)NC1=CCc1cc(F)ccc12,,CCOC(C)=O,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080004295A1,Cc1ccc(S(=O)(=O)Cl)cc1.Nc1nc(Cl)c2ccnc-2[nH]1>>Cc1ccc(S(=O)(=O)n2ccc3c(Cl)nc(N)nc32)cc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US06544976B1,O=C(Cl)C(=O)Cl.O=C(O)[C@@H]1CCN1C(=O)OCc1ccccc1>>O=C(Cl)[C@@H]1CCN1C(=O)OCc1ccccc1,,ClCCl,,CN(C)C=O,,val
US06180615B2,C#CCBr.Oc1ccccc1-c1ccccc1>>C#CCOc1ccccc1-c1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20020103371A1,COc1ccc(CNCC(=O)O)c(OC)c1.O=c1[nH]c2ccc(Br)cc2c(=O)o1>>COc1ccc(CN2CC(=O)Nc3ccc(Br)cc3C2=O)c(OC)c1,,Cc1ccc(C)cc1,,,,val
US07034039B2,CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)(C)C)c(=O)c2ccc(CC(N)=O)cc12.Cl>>CCCCOc1c(CN)n(CC(C)(C)C)c(=O)c2ccc(CC(N)=O)cc12.Cl,,CCOC(C)=O,,,,val
US20120283264A1,COc1cccc([C@@H](O)[C@H](NC(=O)OC(C)(C)C)c2cncc(Br)c2)c1>>COc1cccc([C@H]2OC(=O)N[C@@H]2c2cncc(Br)c2)c1,,O=C(O)C(F)(F)F,,O=C(n1ccnc1)n1ccnc1,,val
US20040106653A1,C[C@H](Cc1ccc(S(=O)(=O)c2ccc(O)c(C(=O)[O-])c2)cc1)N(C[C@H](O)c1ccccc1)C(=O)OC(C)(C)C>>C[C@H](Cc1ccc(S(=O)(=O)c2ccc(O)c(C(=O)O)c2)cc1)N(C[C@H](O)c1ccccc1)C(=O)OC(C)(C)C,,CCO,,Cl,[Na+].[OH-],val
US20060111357A1,CCN1CCN(c2cc(C)c3cc([N+](=O)[O-])ccc3n2)CC1>>CCN1CCN(c2cc(C)c3cc(N)ccc3n2)CC1,[Pd],C1CCOC1,,[H][H],,val
US20160263122A1,O=C(CN1CCOCC1)Nc1cc(NC(=O)c2ccc(Cl)nc2)ccc1OC(F)(F)F.OB(O)c1cc(F)cc(F)c1>>O=C(CN1CCOCC1)Nc1cc(NC(=O)c2ccc(-c3cc(F)cc(F)c3)nc2)ccc1OC(F)(F)F,,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20070123527A1,C=C[Mg]Br.COc1ccc([N+](=O)[O-])cc1Br>>COc1ccc2[nH]ccc2c1Br,,C1CCOC1,,,,val
US20090105250A1,Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1[N+](=O)[O-].O=C(O)c1cnc(Br)s1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)c1cnc(Br)s1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04452789,CCOC(=O)c1cocc1C(=O)OCC>>CCOC(=O)c1cocc1C(=O)O,,CCO,,[K+].[OH-],,val
US20110190297A1,NC(=O)C1CCN(c2c(Cl)cncc2Cl)CC1.OO>>NC(=O)C1CCN(c2c(Cl)c[n+]([O-])cc2Cl)CC1,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US05861395,N#CN=C(Oc1ccccc1)Oc1ccccc1.O=C(CC1CCNCC1)N1CCN(C2c3ccc(Cl)cc3CCc3cc(Br)cnc32)CC1>>N#CN=C(Oc1ccccc1)N1CCC(CC(=O)N2CCN(C3c4ccc(Cl)cc4CCc4cc(Br)cnc43)CC2)CC1,,CC(C)O,,,,val
US20120328569A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(OC)c(-c4nc5ccc(N)cc5o4)c3)cc12.II>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(OC)c(-c4nc5ccc(I)cc5o4)c3)cc12,[Cu]I,C1CCOC1,ClCCl,,,val
US05486534,CSc1ccc(C(=O)Cc2ccc(F)cc2)cc1.O=C(n1ccnc1)C(F)(F)F>>CSc1ccc(-c2n[nH]c(C(F)(F)F)c2-c2ccc(F)cc2)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20110053940A1,NC1CC1.O=C(O)c1cc(Br)cc(Br)c1>>O=C(NC1CC1)c1cc(Br)cc(Br)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05807880,CC(O)c1ccc2c(c1)Cc1ccccc1-2.O=S(Cl)Cl>>CC(Cl)c1ccc2c(c1)Cc1ccccc1-2,,ClCCl,,CN(C)C=O,,val
US20110269773A1,CC1OCc2ncnc(Cl)c21.C[C@H]1CN(C(=O)OC(C)(C)C)CCN1>>CC1OCc2ncnc(N3CCN(C(=O)OC(C)(C)C)C[C@@H]3C)c21,,CCOC(C)=O,O,CN1CCCC1=O,,val
US20090069288A1,CCOC(=O)C(=O)CC(=O)c1ccc(CC(C)C)cc1.NO>>CCOC(=O)c1cc(-c2ccc(CC(C)C)cc2)on1,,CCO,,Cl,O,val
US20150057265A1,CC(C)(C)OC(=O)N[C@@H]1CNC[C@H](C(F)(F)F)C1.O=[N+]([O-])c1cnsc1Br>>CC(C)(C)OC(=O)N[C@H]1C[C@@H](C(F)(F)F)CN(c2sncc2[N+](=O)[O-])C1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20150284411A1,O=C[C@@]1(O)CO[C@@H]2[C@H](Oc3nc4nc(-c5ccc(-c6ccccc6)cc5)c(Cl)cc4[nH]3)CO[C@@H]21>>OC[C@@]1(O)CO[C@@H]2[C@H](Oc3nc4nc(-c5ccc(-c6ccccc6)cc5)c(Cl)cc4[nH]3)CO[C@@H]21,,CO,,[BH4-].[Na+],,val
US20090036444A1,CC(=O)N(C)c1ccc(N2CCOCC2)c(CO)c1.O=S(Cl)Cl>>CC(=O)N(C)c1ccc(N2CCOCC2)c(CCl)c1,,ClC(Cl)Cl,,CCN(CC)CC,CCOC(C)=O,val
US20140349990A1,Cc1c(C(Nc2cc(Cl)c(=O)n(C)c2)c2ccc(Cl)cc2)c(C(=O)O)nn1C1CC1>>Cc1c2c(nn1C1CC1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1,,CO,ClCCl,,,val
US20100239576A1,COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)OC(=O)[C@H](C)N)n(-c5ccccc5)c4=O)cc3F)c2cc1OC.Cl>>COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)OC(=O)[C@H](C)N)n(-c5ccccc5)c4=O)cc3F)c2cc1OC.Cl,,CCOC(C)=O,,,,val
US20130053382A1,C[Si](C)(C)CCOCn1ncc2cc(-c3cccc(CN4CCCCC4)c3)c(NC(=O)c3csc(-c4cc(C(F)(F)F)nn4C4CCCCO4)n3)cc21.ClCCl>>Cl.O=C(Nc1cc2[nH]ncc2cc1-c1cccc(CN2CCCCC2)c1)c1csc(-c2cc(C(F)(F)F)n[nH]2)n1,O,,,O=C(O)C(F)(F)F,,val
US04406829,CC1(C)[C@@H](C=C2CCCC2)[C@H]1C(=O)O.CCOC(=NC(C)C)NC(C)C>>CCOC(=O)[C@@H]1[C@H](C=C2CCCC2)C1(C)C,,CCOC(C)=O,,,,val
US20070225271A1,CCOc1cc(C=O)ccc1OC.CCc1cnc(NC2CCNCC2)nc1>>CCOc1cc(CN2CCC(Nc3ncc(CC)cn3)CC2)ccc1OC,,CCO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20110112063A1,Clc1ncc(Cl)c(Cl)n1.Nc1cc(C(F)(F)F)[nH]n1>>FC(F)(F)c1cc(Nc2nc(Cl)ncc2Cl)n[nH]1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20060211714A1,CC(C)(C)OC(=O)N1CCC[C@@H]1COc1cc(OCc2ccccc2)cc2ncnc(Nc3ccc(F)c(Cl)c3)c12>>CC(C)(C)OC(=O)N1CCC[C@@H]1COc1cc(O)cc2ncnc(Nc3ccc(F)c(Cl)c3)c12,[Pd],CCO,,,,val
US20160207893A1,COC(=O)c1ccc(C=O)cc1OC.COc1ccc2c(n1)CNCCS2>>COC(=O)c1ccc(CN2CCSc3ccc(OC)nc3C2)cc1OC,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140179680A1,C[C@@H]1CC[C@@H](Cn2c(C(=O)c3ncccc3F)nc3cc(Cl)nc(-c4cncc(Cl)c4)c32)CC1.C[Mg]Br>>C[C@@H]1CC[C@@H](Cn2c(C(C)(O)c3ncccc3F)nc3cc(Cl)nc(-c4cncc(Cl)c4)c32)CC1,,C1CCOC1,,,,val
US20100120730A1,COc1ccc(Cc2nc3c(c4c2[nH]c2ccccc24)C(=O)CC(C)(C)C3)cc1>>COc1ccc(Cc2nc3c(c4c2[nH]c2ccccc24)C(O)CC(C)(C)C3)cc1,,CO,,[BH4-].[Na+],,val
US20130143906A1,Cc1cc(CCl)c(F)cc1F.Cc1ccc(-c2ccnc(C(C)(C)O)n2)cc1-n1c(C)nc(O)c(Cl)c1=O>>Cc1cc(COc2nc(C)n(-c3cc(-c4ccnc(C(C)(C)O)n4)ccc3C)c(=O)c2Cl)c(F)cc1F,,CN(C)C=O,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20100009956A1,CC1CCC(N(NC(=O)OC(C)(C)C)c2nc(C#N)ncc2Br)C1>>CC1CCC(N(N)c2nc(C#N)ncc2Br)C1,,CC#N,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05219871,CN(CCCC(C#N)(c1ccccc1)c1ccccc1)Cc1ccccc1.O=S(=O)(O)O>>CN(CCCC(C(N)=O)(c1ccccc1)c1ccccc1)Cc1ccccc1,,O=S(=O)(O)O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20110046157A1,CO.COC(=O)c1cc2ccncc2s1>>COC(=O)c1cc2c(s1)CN(C)CC2,O=[Pt]=O,CO,,CC#N,,val
US20090048306A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.FC(F)Oc1ccccc1Br>>CC1(C)OB(c2ccccc2OC(F)F)OC1(C)C,,CN(C)C=O,,CC(=O)[O-].[K+],,val
US03968234,OCC=Cc1ccccc1.Oc1ccc2c(c1)OCO2>>Oc1cc2c(cc1C=CCc1ccccc1)OCO2,,O=CO,,,,val
US05599832,BrBr.O=S(=O)(c1cc2cc(Cl)c(Cl)cc2[nH]1)C(F)(F)C(F)Cl>>O=S(=O)(c1[nH]c2cc(Cl)c(Cl)cc2c1Br)C(F)(F)C(F)Cl,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20050032846A1,C=CCBr.CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N>>C=CCNc1c(NC(CC)CC)cc(C)nc1Oc1c(C)cc(C)cc1C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20150038437A1,CCCC(=O)c1ccc2c(c1)cc(C1CCN(C(=O)OC(C)(C)C)C1)n2C.COc1ccc(CN)c(OC)c1>>CCCC(=NCc1ccc(OC)cc1OC)c1ccc2c(c1)cc(C1CCN(C(=O)OC(C)(C)C)C1)n2C,Cl[Ti](Cl)(Cl)Cl,ClCCl,,CCN(CC)CC,,val
US04608442,CCCCCC1C(=O)C=CC1(C)OC(C)=O>>CCCCCC1=C(C)C(O)CC1=O,,C1CCOC1,,O=S(=O)(O)O,,val
US20160122358A1,CC(C)(C)OC(=O)N1Cc2c(C(N)=O)c(I)nn2CC1C(F)(F)F.OB(O)c1ccc(F)c(Cl)c1>>CC(C)(C)OC(=O)N1Cc2c(C(N)=O)c(-c3ccc(F)c(Cl)c3)nn2CC1C(F)(F)F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US04247559,Nc1ccc(S(=O)(=O)C(I)I)cc1.O=C1C=CC(=O)O1>>O=C1C=CC(=O)N1c1ccc(S(=O)(=O)C(I)I)cc1,,CC(=O)O,,,,val
US20090291983A1,CCOC(=O)C1c2ccccc2C(=O)N1Cc1ccc(F)cc1OC>>COc1cc(F)ccc1CN1C(=O)c2ccccc2C1C(=O)O,,CO,,Cl,,val
US20080312192A1,O=C(c1cc([N+](=O)[O-])cc(C(F)(F)F)c1)N1CCC1>>Nc1cc(C(=O)N2CCC2)cc(C(F)(F)F)c1,[Ni],CCO,,,,val
US06194410B1,CSc1nn2c(Cl)cc(C)nc2c1S(=O)(=O)c1ccc(Br)cc1.N>>CSc1nn2c(N)cc(C)nc2c1S(=O)(=O)c1ccc(Br)cc1,,CO,,,,val
US20030144266A1,CN1CCN(S(=O)(=O)c2ccc(N)cc2)CC1.O=C(Cl)OC(Cl)(Cl)Cl>>CN1CCN(S(=O)(=O)c2ccc(N=C=O)cc2)CC1,,c1ccccc1,,,,val
US20140235591A1,COC(=O)[C@@]1(N)CC[C@@H](c2ccc(Br)cc2)C1>>N[C@]1(CO)CC[C@@H](c2ccc(Br)cc2)C1,,CO,,[BH4-].[Na+],,val
US20040073025A1,COC(=O)[C@@H](CC1CC1)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@H](CC1CC1)C(=O)O,,CO,,[Na+].[OH-],,val
US20100266714A1,C[C@@H](NS(=O)C(C)(C)C)c1ccc(F)cn1>>C[C@@H](N)c1ccc(F)cn1,,CO,,Cl,,val
US20130310405A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c5c(-c6ccc(C#N)cc6)cccc5nn4cc3-c3ccccc3)cc2)CCC1>>N#Cc1ccc(-c2cccc3nn4cc(-c5ccccc5)c(-c5ccc(C6(N)CCC6)cc5)nc4c23)cc1,,C1COCCO1,Cl,,,val
US08138168B1,COCCCn1c([C@@H]2CCCN(C(=O)OC(C)(C)C)C2)nc2cccc(Cl)c21>>COCCCn1c([C@@H]2CCCNC2)nc2cccc(Cl)c21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100125085A1,Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.Cl>>Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.Cl,,CO,,,,val
US20070082939A1,CCCN.O=C1OC(=O)C2(c3ccc(Cl)c(Cl)c3)CC12>>CCCNC(=O)C1(c2ccc(Cl)c(Cl)c2)CC1C(=O)O,,C1CCOC1,,CCOC(C)=O,,val
US06410556B1,CC(C)(C)OC(=O)c1c(N)sc2c1C[C@@H](CO)N(C(=O)OC(C)(C)C)C2.O=C1NC(=O)c2ccccc21>>CC(C)(C)OC(=O)c1c(N)sc2c1C[C@@H](CN1C(=O)c3ccccc3C1=O)N(C(=O)OC(C)(C)C)C2,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110257241A1,CC(C)(C)OC(=O)N1CCC(O)(c2cc(F)cc(Cl)c2)C1.CI>>COC1(c2cc(F)cc(Cl)c2)CCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,[H-].[Na+],,val
US20080139631A1,CCCc1cc2c(C(F)(F)F)c(C#N)ccc2n1CC(=N)NO.O=C(Cl)c1cc(Cl)ccc1Br>>CCCc1cc2c(C(F)(F)F)c(C#N)ccc2n1Cc1noc(-c2cc(Cl)ccc2Br)n1,,CC#N,,CCN(CC)CC,,val
US20060257987A1,CCCC(CCOc1ccc(OC(C)(C)C(=O)OCC)cc1)Oc1ccc2c(-c3ccccc3)coc2c1>>CCCC(CCOc1ccc(OC(C)(C)C(=O)O)cc1)Oc1ccc2c(-c3ccccc3)coc2c1,,CCO,O,Cl,[Na+].[OH-],val
US20120129840A1,CCCC(C(=O)OC)c1c(C)nc(-c2ccccc2)nc1-c1ccc2c(c1)OCCCO2>>CCCC(C(=O)O)c1c(C)nc(-c2ccccc2)nc1-c1ccc2c(c1)OCCCO2,,CO,,[Na+].[OH-],,val
US20020028836A1,N#CN.S=C=Nc1cccnc1>>N#CNC(=S)Nc1cccnc1,,C1CCOC1,,[H-].[Na+],,val
US20160102067A1,CC(=O)OC(C)=O.CCCCCCCCCC(O)C(C)[N+](=O)[O-]>>CCCCCCCCCC(OC(C)=O)C(C)[N+](=O)[O-],O=S(=O)(O)O,O,,,,val
US20060069110A1,CN(c1ccnc(F)n1)c1ccnc(-c2ccccc2)n1.[N-]=[N+]=NC[C@H](N)Cc1ccccc1>>CN(c1ccnc(N[C@@H](CN=[N+]=[N-])Cc2ccccc2)n1)c1ccnc(-c2ccccc2)n1,,CN1CCCC1=O,,,,val
US20040048908A1,CCOC(=O)CC(=O)OCC.Cc1onc(-c2ccc(Cl)cc2)c1CCl>>Cc1onc(-c2ccc(Cl)cc2)c1CCC(=O)O,,C1CCOC1,,Cl,[H-].[Na+],val
US20050095528A1,CCCCCCCCCCCCBr.O=c1c2ccccc2sc2c(O)ccc(Cl)c12>>CCCCCCCCCCCCOc1ccc(Cl)c2c(=O)c3ccccc3sc12,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04061498,CCCCCCCCCCCCCC(=O)Nc1ccc(Cl)c(Nc2cc(=O)n(-c3c(Cl)cc(Cl)cc3Cl)n2C(=O)OCC)c1.O=S(=O)(Cl)Cl>>CCCCCCCCCCCCCC(=O)Nc1ccc(Cl)c(Nc2c(Cl)c(=O)n(-c3c(Cl)cc(Cl)cc3Cl)n2C(=O)OCC)c1,,ClCCl,,,,val
US20140080808A1,Cn1cc(-c2ccc(C3(c4nnc5n4CCS[C@](C)(CO[Si](C)(C)C(C)(C)C)C5)CC3)cc2)cn1>>Cn1cc(-c2ccc(C3(c4nnc5n4CCS[C@](C)(CO)C5)CC3)cc2)cn1,,C1COCCO1,CO,Cl,,val
US03976786,CC(=O)OC(C)=O.Nc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1>>CC(=O)Nc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1,,CCOCC,,O=S(=O)(O)O,,val
US20160185784A1,CI.O=C1N[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]2CC[C@@H](c3cc(C(F)(F)F)ccc3Cl)N12>>CN1C(=O)N2[C@@H](CC[C@H]2c2cc(C(F)(F)F)ccc2Cl)[C@H]1c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CN(C)C=O,,[H-].[Na+],,val
US20150225397A1,CC1c2oncc2CC2(Cc3ccccc3)c3nn(C)c(-c4ccccc4)c3CCC12>>CC1C(=O)C(C#N)CC2(Cc3ccccc3)c3nn(C)c(-c4ccccc4)c3CCC12,,C1CCOC1,CO,C[O-].[Na+],,val
US20120214767A1,NO.O=Cc1noc(-c2ccccc2)c1C(F)(F)F>>ON=Cc1noc(-c2ccccc2)c1C(F)(F)F,,CO,,Cl,CC(=O)[O-].[Na+],val
US20090264416A1,C[C@@H]1CNCCN1Cc1cccc(C(=O)NC(C)(C)C)c1.Nc1ccc(C(=O)O)cc1F>>C[C@@H]1CN(C(=O)c2ccc(N)c(F)c2)CCN1Cc1cccc(C(=O)NC(C)(C)C)c1,,ClCCl,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US20120258946A1,Nc1cccc(Cl)c1Cl.O=N[O-]>>NNc1cccc(Cl)c1Cl,,Cl,O,Cl[Sn]Cl,,val
US20110053911A1,CI.N#Cc1ccc(-n2cc3c(C(=O)O)cccc3n2)cc1>>COC(=O)c1cccc2nn(-c3ccc(C#N)cc3)cc12,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120053171A1,Nc1ccccc1C(F)(F)F.O=C(Cl)Oc1ccccc1>>O=C(Nc1ccccc1C(F)(F)F)Oc1ccccc1,,C1CCOC1,,O,c1ccncc1,val
US20070213330A1,CC1(c2cc(CO)no2)OCCO1>>CC(=O)c1cc(CO)no1,,CO,,[Na+].[OH-],,val
US04229449,COc1ccccc1OC(c1ccccc1)C(O)CNNCc1ccccc1.O=C(Cl)CCl>>COc1ccccc1OC(c1ccccc1)C(O)CN(Cc1ccccc1)C(=O)CCl,,ClCCl,,O,[Na+].[OH-],val
US05753664,CCn1c(SC)nc2c(ccn2Cc2ccc(C(=O)c3ccc(Cl)cc3)cc2)c1=O>>CCn1cnc2c(ccn2Cc2ccc(C(=O)c3ccc(Cl)cc3)cc2)c1=O,[Ni],CCO,COCCOC,CC(=O)O,,val
US05081254,CCOC(=O)C(=CNC1CC1)C(=O)c1cc(F)c(C2CCC3(C2)OCCO3)cc1F>>CCOC(=O)c1cn(C2CC2)c2cc(C3CCC4(C3)OCCO4)c(F)cc2c1=O,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20120046267A1,CC(C)(C)Sc1c(Br)cc(F)cc1C=O.NO>>CC(C)(C)Sc1c(Br)cc(F)cc1C=NO,,CC(C)O,O,Cl,,val
US20080194659A1,COC(=O)/C=C/c1ccc2[nH]ccc2c1>>O=C(O)/C=C/c1ccc2[nH]ccc2c1,,CO,O,Cl,[Li+].[OH-],val
US20130190332A1,Cc1cc(-c2ccc3nc(-c4ccc(C5(NC(=O)OC(C)(C)C)CCC5)cc4)c(-c4ccccc4)n3c2)n(C(=O)OC(C)(C)C)n1>>Cc1cc(-c2ccc3nc(-c4ccc(C5(N)CCC5)cc4)c(-c4ccccc4)n3c2)[nH]n1,,CO,ClCCl,Cl,[Na+].[OH-],val
US20110059941A1,CC(C)Oc1cc(OCc2ccccc2)cc(C(=O)O)c1.Nc1cccnc1N>>CC(C)Oc1cc(OCc2ccccc2)cc(C(=O)Nc2cccnc2N)c1,CN(C)c1ccncc1,CN(C)C=O,,,,val
US20100130557A1,Cn1ccc2ccc(NS(=O)(=O)c3cc(Cl)cc(Cl)c3)cc21.O=C(Cl)C(=O)Cl>>Cn1cc(C(=O)C(=O)Cl)c2ccc(NS(=O)(=O)c3cc(Cl)cc(Cl)c3)cc21,,CCOCC,,,,val
US05633276,CCOC(CBr)OCC.Nc1cccc2c1CCCO2>>CCOC(CNc1cccc2c1CCCO2)OCC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04507498,CCCC1(OCCCCCBr)CC(OCC(=O)OCC)=CC=C1C(C)=O.CCCc1c(O)c(Cl)cc(C(C)=O)c1O>>CCCc1c(O)c(C(C)=O)cc(Cl)c1OCCCCCOc1c(C(C)=O)ccc(OCC(=O)OCC)c1CCC,,CN(C)C=O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20140135322A1,COC(=O)Cc1ccsc1-c1ccc(-c2sccc2CC(=O)OC)cc1.O=C1CCC(=O)N1Br>>COC(=O)Cc1ccsc1-c1ccc(-c2sc(Br)cc2CC(=O)OC)cc1,,ClC(Cl)Cl,ClCCl,CC(=O)O,,val
US20020065271A1,CC(C)(C)OC(=O)[C@H](CNC(=O)c1ccc(CCC(=O)NC2=NCCCN2)cc1)NS(=O)(=O)c1ccccc1C(=O)NC1=NCCCN1>>O=C(CCc1ccc(C(=O)NC[C@H](NS(=O)(=O)c2ccccc2C(=O)NC2=NCCCN2)C(=O)O)cc1)NC1=NCCCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090264434A1,CC(C)CC(C(=O)Nc1ccn(C[C@@H]2COC(C)(C)O2)n1)n1ncc(Nc2ccccc2Cl)cc1=O>>CC(C)CC(C(=O)Nc1ccn(C[C@@H](O)CO)n1)n1ncc(Nc2ccccc2Cl)cc1=O,,C1CCOC1,,Cl,,val
US20150336953A1,C#CCN.CSc1nc(Cl)cc(Cl)n1>>C#CCNc1cc(Cl)nc(SC)n1,,CC#N,,O,,val
US20050239841A1,CCc1ccc(C(=O)O)nc1.COc1ccc([C@@]23CC[C@@H](N)C[C@@H]2N(C)CC3)cc1OC.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCc1ccc(NC(=O)N[C@@H]2CC[C@@]3(c4ccc(OC)c(OC)c4)CCN(C)[C@H]3C2)nc1,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US20110118246A1,Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12.O=C(O)c1ncccc1F>>O=C(Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12)c1ncccc1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150005279A1,COC(=O)c1cncc2ccn(S(=O)(=O)c3ccc(C)cc3)c12.O=C(OO)c1cccc(Cl)c1>>COC(=O)c1c[n+]([O-])cc2ccn(S(=O)(=O)c3ccc(C)cc3)c12,,CCOC(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US04163058,CN(C)CC(=O)O.O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1CO>>CN(C)CC(=O)OCN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O,,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150291573A1,CS(=O)(=O)Cl.OC1CCOC(c2ccc(Br)cc2F)C1>>CS(=O)(=O)OC1CCOC(c2ccc(Br)cc2F)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20050101637A1,Cc1ccc(-c2nc(CO[C@@H]3CCC[C@H](COC(C)(C)C(=O)OC(C)(C)C)C3)c(C)o2)cc1>>Cc1ccc(-c2nc(CO[C@@H]3CCC[C@H](COC(C)(C)C(=O)O)C3)c(C)o2)cc1,,O=C(O)C(F)(F)F,,,,val
US20030022887A1,COc1cc(-c2cc(CN3CCNCC3)ccn2)cc(OC)c1OC.COc1cc(-c2ccc(C(=O)Cl)cc2)cc(OC)c1OC>>COc1cc(-c2ccc(C(=O)N3CCN(Cc4ccnc(-c5cc(OC)c(OC)c(OC)c5)c4)CC3)cc2)cc(OC)c1OC,,ClCCl,,O,O=C([O-])O.[Na+],val
US20110237629A1,CC1(C)OC[C@H](COc2ccc(-c3c(C#N)c(N)nc(SCc4coc(-c5ccc(Cl)cc5)n4)c3C#N)cc2)O1>>N#Cc1c(N)nc(SCc2coc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1ccc(OC[C@H](O)CO)cc1,,CCO,,Cl,,val
US20080045528A1,CC(C)(C)OC(=O)NN.O=C(O)c1cc(Oc2ccc3nc(NCC4CCCCC4)oc3c2)ccn1>>NNC(=O)c1cc(Oc2ccc3nc(NCC4CCCCC4)oc3c2)ccn1,,CCN(CC)CC,,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,,val
US04572908,CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl.CSC(=NC#N)SC>>CCOC(=O)C1=C(COCCNC(=NC#N)SC)NC(C)=C(C(=O)OC)C1c1ccccc1Cl,,CC(C)O,,CCOCC,,val
US20140303186A1,COC(=O)Cc1nn(Cc2ccc(N)cc2)c2ncccc12.O=C(Cl)c1ccc2ccccc2c1>>COC(=O)Cc1nn(Cc2ccc(NC(=O)c3ccc4ccccc4c3)cc2)c2ncccc12,,ClCCl,,CCN(CC)CC,,val
US20110118236A1,CCOC(=O)c1cc2n(n1)CCC(C(=O)OCC)C2=O>>O=C(O)c1cc2n(n1)CCCC2=O,,O,,Cl,,val
US20130237490A2,COC(=O)c1c(C)cc2c(c1O)[C@]1(O)C(=O)c3cc4c(c(O)c3C(=O)[C@]1(OC)[C@H](O)C2)C(=O)C=C(N[C@H]1O[C@@H](C)[C@H](OC)[C@@H](O[C@H]2O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)[C@H]1OC)C4=O>>COC(=O)c1c(C)cc2c(c1O)[C@]1(O)C(=O)c3cc4c(c(O)c3C(=O)[C@]1(OC)[C@H](O)C2)C(=O)C=C(N[C@H]1O[C@@H](C)[C@H](OC)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1OC)C4=O,,CO,,O=C([O-])[O-].[K+].[K+],,val
US04514409,CC(C)(C=C(Cl)Cl)CCCl>>C=CC(C)(C)C=C(Cl)Cl,,c1ccc2ncccc2c1,,,,val
US20110319378A1,COC(=O)[C@H](CO)[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N([C@H](CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C2CC2)C1=O.CS(=O)(=O)Cl>>COC(=O)[C@H](COS(C)(=O)=O)[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N([C@H](CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C2CC2)C1=O,,ClCCl,,CCN(CC)CC,,val
US20150218169A1,COC(=O)C1CCN(Cc2ccccc2)CC1O>>COC(=O)C1CCNCC1O,[Pd],CO,,,,val
US04396618,CC(=O)SCC1=C(C(=O)O)N2C(=O)C(N)[C@H]2SC1.CON=C(C(=O)O)c1csc(NC(=O)CCl)n1>>CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSC(C)=O)CS[C@H]12)c1csc(NC(=O)CCl)n1,,CCN(CC)CC,ClCCl,O=S(Cl)Cl,,val
US20100130497A1,CCC#CCBr.COc1cc(C=O)ccc1O>>CCC#CCOc1cc(C=O)ccc1OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100029617A1,CCCCOC(=O)C=Cc1cc(F)c(C)c(F)c1>>CCCCOC(=O)CCc1cc(F)c(C)c(F)c1,[Pd],CO,,C,,val
US20150329548A1,C[C@@H]1CC[C@@H](Cn2c(C(F)c3ccccc3F)cc3nc(C#N)nc(-c4cncc(Cl)c4)c32)CC1.NO>>C[C@@H]1CC[C@@H](Cn2c(C(F)c3ccccc3F)cc3nc(C(N)=NO)nc(-c4cncc(Cl)c4)c32)CC1,,CCO,O,Cl,O=C([O-])O.[Na+],val
US20150038528A1,CCOC(=O)c1ncc2cc(Oc3ccc(F)cc3Cl)ccc2c1O.O=C1CCC(=O)N1Br>>CCOC(=O)c1nc(Br)c2cc(Oc3ccc(F)cc3Cl)ccc2c1O,,ClCCl,,,,val
US20150344466A1,CC(=O)CCCc1ccc(Cl)c(Cl)c1.CCOC(=O)C(=O)OCC>>CCOC(=O)C(=O)CC(=O)CCCc1ccc(Cl)c(Cl)c1,,CCO,,C,C[O-].[Na+],val
US20120245161A1,COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)OC(C)(C)C)ccc3OCC(=O)N(C)C)CC2)c2cccc(C)c21.Cl>>COCCn1cc(C(=O)N2CCC(c3cc(CN)ccc3OCC(=O)N(C)C)CC2)c2cccc(C)c21.Cl,,C1COCCO1,,,,val
US20160264567A1,O=C1c2ccccc2C(=O)N1Cc1cc(B(O)O)c(F)cn1.OO>>O=C1c2ccccc2C(=O)N1Cc1cc(O)c(F)cn1,,CC(C)=O,,,,val
US20050137203A1,Nc1ccc(-c2ccc(NC3CN4CCC3CC4)cc2)cc1.O=C(O)/C=C/C(=O)O>>Nc1ccc(-c2ccc(NC3CN4CCC3CC4)cc2)cc1.O=C(O)/C=C/C(=O)O,,CCOC(C)=O,CO,,,val
US20160046592A1,NCc1cnco1.O=C(CBr)OCc1ccccc1>>O=C(CNCc1cnco1)OCc1ccccc1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US05350762,CS(=O)(=O)Cl.Cn1c2c(c3cc(OCc4ccccc4)ccc31)CC(CO)C2>>Cn1c2c(c3cc(COc4ccccc4)ccc31)CC(COS(C)(=O)=O)C2,,ClCCl,,CCN(CC)CC,O,val
US20150283094A1,CO.COC(OC)OC.COc1cc(OCCCN=[N+]=[N-])ccc1C=O>>COc1cc(OCCCN=[N+]=[N-])ccc1C(OC)OC,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20040147523A1,COc1cccc2c(C3=CCN(C(=O)OC(C)(C)C)CC3)coc12>>COc1cccc2c(C3=CCNCC3)coc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US04076818,COc1ccc(CBr)cc1.O=c1[nH]c2ccccc2c2cc(CO)nn12>>COc1ccc(Cn2c(=O)n3nc(CO)cc3c3ccccc32)cc1,,CO,,[I-].[K+],,val
US04742069,CCN1C(C)=CC(=O)CS1(=O)=O.N>>CCNS(=O)(=O)CC(=O)C=C(C)N,,CO,,,,val
US20050043537A1,CCOC(OCC)OCC.COCCOc1ccc(N)cc1I.COc1cc(NC(=O)CC#N)c(Cl)cc1Cl>>COCCOc1ccc(NC=C(C#N)C(=O)Nc2cc(OC)c(Cl)cc2Cl)cc1I,,CC(C)O,,,,val
US20080182852A1,CCOC(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.CN1CCN(c2cccc(N)c2)CC1>>CCOC(=O)c1ccccc1Nc1nc(Nc2cccc(N3CCN(C)CC3)c2)ncc1Cl,,CCO,,Cl,,val
US20120088767A1,COC(=O)c1cc(N2CCOCC2)cc2nc(C)[nH]c12.Cc1cccc(CBr)c1F>>COC(=O)c1cc(N2CCOCC2)cc2c1nc(C)n2Cc1cccc(C)c1F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20030162787A1,Cc1ccc[nH]c1=O.O=[N+]([O-])c1ccc(I)cc1>>Cc1cccn(-c2ccc([N+](=O)[O-])cc2)c1=O,[Cu]I,C1COCCO1,CCOC(C)=O,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20080167307A1,CCCCCCCN(CCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1)C(=O)Nc1ccc(F)cc1F>>CCCCCCCN(CCc1csc(SC(C)(C)C(=O)O)n1)C(=O)Nc1ccc(F)cc1F,,O,,O=CO,,val
US20090197926A1,CCOC(=O)C1CCC(Oc2ccc(N)c([N+](=O)[O-])c2)CC1.COC(=O)C(=O)Cl>>CCOC(=O)[C@@H]1CC[C@H](Oc2ccc(NC(=O)C(=O)OC)c([N+](=O)[O-])c2)CC1,,ClCCl,,c1ccncc1,,val
US20030166644A1,CN(C(=O)Cl)c1ccccc1.O=C1CCC(=O)N1c1ccc(O)nc1>>CN(C(=O)Oc1ccc(N2C(=O)CCC2=O)cn1)c1ccccc1,,C1CCOC1,,C1CN2CCN1CC2,,val
US20140206875A1,N.O=C1C2CC3CC1CC(C(=O)O)(C3)C2>>NC1C2CC3CC1CC(C(=O)O)(C3)C2,[Pd],CO,,O,,val
US20130096118A1,COCCOc1ccc2c(c1)[nH]c1c(C(N)=O)ncc(-c3cccc(-n4cnc5ccccc5c4=O)c3C)c12>>Cc1c(-c2cnc(C(N)=O)c3[nH]c4cc(OCCO)ccc4c23)cccc1-n1cnc2ccccc2c1=O,,ClCCl,,BrB(Br)Br,,val
US20110237628A1,CS(=O)(=O)Cl.OCC(c1c2c(nn1-c1ccc(Cl)cc1)CCC2)C1CCCCC1>>CS(=O)(=O)OCC(c1c2c(nn1-c1ccc(Cl)cc1)CCC2)C1CCCCC1,,ClCCl,O,CCN(CC)CC,,val
US20110288066A1,CS(=O)(=O)Cl.Cc1ccc(N)cc1Br>>Cc1ccc(NS(C)(=O)=O)cc1Br,,c1ccncc1,,CCOC(C)=O,,val
US03933794,CC(=O)O.Cc1cnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=[N+]([O-])C2>>CC(=O)O.Cc1cnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2O,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20090312328A1,COC(=O)c1cc(C#N)ccn1.N>>NCc1ccnc(C(N)=O)c1,[Ni],CCO,,,,val
US20140051679A1,CCNc1ccccc1.Nc1ccc2c(c1)c(-c1ccc(N3CCOCC3)cc1)nn2C1CCCCO1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCN(C(=O)Nc1ccc2[nH]nc(-c3ccc(N4CCOCC4)cc3)c2c1)c1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06288061B1,CC(C)(C)OC(=O)C(=NO)C(=O)c1cnccn1.NCc1ccccc1>>CC(C)(C)OC(=O)c1nc(-c2ccccc2)[nH]c1-c1cnccn1,,CC#N,,,,val
US20030134862A1,N#CCc1n[nH]c(N)c1C#N.O=Cc1cccs1>>N#CC(=Cc1cccs1)c1n[nH]c(N)c1C#N,,CCO,,C1CCNCC1,,val
US20040023973A1,N#Cc1ccccc1-c1cc(-c2ccccn2)cn(-c2cccc(C=O)c2)c1=O>>N#Cc1ccccc1-c1cc(-c2ccccn2)cn(-c2cccc(CO)c2)c1=O,,CCOC(C)=O,CO,[BH4-].[Na+],,val
US20120149676A1,Cn1c(Nc2c(Cl)ccc(CNC(=O)OC(C)(C)C)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21>>Cn1c(Nc2c(Cl)ccc(CN)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21,,C1CCOC1,,Cl,,val
US20060041129A1,CCCC(=O)Nc1snc(C)c1C#N.OO>>CCCC(=O)Nc1snc(C)c1C(N)=O,,[NH4+],[OH-],,,val
US20090042896A1,CC(=O)/C=C/c1ccc(F)cc1F.COCN(Cc1ccccc1)C[Si](C)(C)C>>CC(=O)C1CN(Cc2ccccc2)CC1c1ccc(F)cc1F,O=C(O)C(F)(F)F,ClCCl,,,,val
US20050261291A1,CC1(C)CC(c2ccccc2N2CCN(C[C@@H]3C[C@H]3CO)CC2)CC(C)(C)C1.CCN(CC)S(F)(F)F>>CC1(C)CC(c2ccccc2N2CCN(C[C@@H]3C[C@H]3CF)CC2)CC(C)(C)C1,,ClCCl,O,CCOC(C)=O,O=C([O-])O.[Na+],val
US20080021032A1,COCCn1ccc(N)n1.Cc1cc([C@@H](CC2CCCC2)C(=O)Cl)ccc1S(C)(=O)=O>>COCCn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(C)c2)n1,,ClCCl,,Cc1cccc(C)n1,,val
US20140045819A1,O=C1CCC(=O)N1Br.O=C1CCc2ccc(Cl)cc2N1>>O=C1CCc2cc(Br)c(Cl)cc2N1,,CN(C)C=O,O,,,val
US20080051409A1,NOc1ccc([N+](=O)[O-])cc1[N+](=O)[O-].OCc1ccncc1>>N[n+]1ccc(CO)cc1.O=[N+]([O-])c1ccc([O-])c([N+](=O)[O-])c1,,ClCCl,,CCOCC,,val
US05885984,CCOCC.Cl.O=C(Cl)Cc1ccc([N+](=O)[O-])cc1.O=C(O)Cc1ccc([N+](=O)[O-])cc1>>Cl.O=C(O)C(c1ccc([N+](=O)[O-])cc1)[C@@H]1CCCC[C@H]1N1CCOCC1,,ClC(Cl)Cl,,,,val
US20150210687A1,O=Cc1c(Cl)cccc1C1CC1>>OCc1c(Cl)cccc1C1CC1,,CO,,,,val
US20160229837A1,CN(C(=O)OC(C)(C)C)C1CCNCC1.N#Cc1ccc(Cl)nc1>>CN(C(=O)OC(C)(C)C)C1CCN(c2ccc(C#N)cn2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06433225B1,COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1.O=C(O)/C=C\C(=O)O>>COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1.O=C(O)/C=C\C(=O)O,,O,,,,val
US20150329538A1,CC(N)c1ccccn1.Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1F>>Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)c1ccccn1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20110105460A1,Cn1c(-c2ccccc2C(F)(F)F)nnc1C(C)(C)Oc1ccc(Cl)cc1C(=O)NCC1COC(C)(C)O1>>Cn1c(-c2ccccc2C(F)(F)F)nnc1C(C)(C)Oc1ccc(Cl)cc1C(=O)NCC(O)CO,,C1CCOC1,,Cl,O,val
US20150232435A1,CCOC(=O)C(=O)CBr.Nc1cccc(CO)n1>>CCOC(=O)c1cn2c(CO)cccc2n1,,CCO,,,,val
US20100311748A1,CNC.Cc1ccc(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2cccc(Br)n2)cc1>>Cc1ccc(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2cccc(N(C)C)n2)cc1,,CN(C)C=O,,,,val
US09346812B2,CNC(=O)c1ccc(-c2cn(COCC[Si](C)(C)C)c3nc(Cl)nc(OC4CCC4)c23)cc1.CNC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.C[Si](C)(C)CCOCn1cc(I)c2c(OC3CCC3)nc(Cl)nc21>>CNC(=O)c1ccc(-c2c[nH]c3nc(Nc4ccc(C(=O)NC5COC5)cc4OC)nc(OC4CCC4)c23)cc1,,O,,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US05506190,CCOC(=O)N1CCC(N)CC1.O=C1C2=C(CCCC2)C(=O)N1c1cc(OC2CCCC2)c(Cl)cc1F>>CCOC(=O)N1CCC(NC(=O)C2=C(C(=O)Nc3cc(OC4CCCC4)c(Cl)cc3F)CCCC2)CC1,,c1ccccc1,,CCN(CC)CC,,val
US20160185780A1,CN1CCC(N(C)C(=O)c2ccc(Nc3nc4c(N5CCC(C=O)(c6ccc(Cl)cc6)CC5)cccn4n3)cc2)CC1.C[Mg]Br>>CC(O)C1(c2ccc(Cl)cc2)CCN(c2cccn3nc(Nc4ccc(C(=O)N(C)C5CCN(C)CC5)cc4)nc23)CC1,,C1CCOC1,,CC#N,O,val
US20090137601A1,COC(=O)[C@@H](N)Cc1ccc(C2=CCNCC2)cc1.O=C(O)c1ccccn1>>COC(=O)[C@@H](N)Cc1ccc(C2=CCN(C(=O)c3ccccn3)CC2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05177077,Fc1ccc(C(Cl)c2ccsc2)cc1.OCCN1CCN(CCCc2ccccc2)CC1>>Fc1ccc(C(OCCN2CCN(CCCc3ccccc3)CC2)c2ccsc2)cc1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20020007071A1,CCOC(=O)C(C)CCBr.Cc1cccc2nc(COc3ccc(Cl)cc3)[nH]c12>>CCOC(=O)C(C)CCn1c(COc2ccc(Cl)cc2)nc2c(C)cccc21,,CN(C)C=O,,O,[H-].[Na+],val
US20100029707A1,C[Si](C)(C)C#CCCOc1ncccn1>>C[Si](C)(C)c1ccnc2c1CCO2,,O=[N+]([O-])c1ccccc1,,,,val
US20050130954A1,CC(C)(C=O)c1ccc(Cl)cc1.Cc1ccc([S@@](N)=O)cc1>>Cc1ccc([S@@](=O)N=CC(C)(C)c2ccc(Cl)cc2)cc1,,ClCCl,,,,val
US20090318546A1,CCCc1c(OCCF)ccc2cc(C(=O)OCC)c(=O)oc12>>CCCc1c(OCCF)ccc2cc(C(=O)O)c(=O)oc12,,C1CCOC1,,[Li+].[OH-],,val
US20040038970A1,CCCCC(=O)CCCC.N[C@H](Cc1c[nH]c2ccccc12)c1nc(-c2ccccc2)cs1>>CCCCC1(CCCC)N[C@@H](c2nc(-c3ccccc3)cs2)Cc2c1[nH]c1ccccc21,,CCCCO,,Cl,,val
US20090018103A1,CC(C)(C)OC(=O)N1CCC[C@@H]([C@@](O)(CCCN)c2cccc(Cl)c2)C1.ClCCl.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CNC(=O)NCCC[C@@](O)(c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20040122001A1,C[C@@H]1CN(c2ccc(F)c3cc(F)ccc23)CCN1C(=O)[O-]>>C[C@@H]1CN(c2ccc(F)c3cc(F)ccc23)CCN1,[Pd],CO,,C,,val
US04327102,Cl.ClCc1ccccn1.Fc1ccc(S)cc1>>Cl.Fc1ccc(SCc2ccccn2)cc1,,CCO,,[Na+].[OH-],,val
US04670560,CCOC(=O)CCCCBr.COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccsc3c2=O)CC1>>CCOC(=O)CCCCn1c(=O)n(CCN2CCN(c3ccccc3OC)CC2)c(=O)c2sccc21,,CN(C)C=O,,,,val
US20110053922A1,C[Si](C)(C)Cl.Cc1cc(F)ccc1[C@H]1C[C@@]2(CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC[C@@](C)(CO)N2>>Cc1cc(F)ccc1[C@H]1C[C@@]2(CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC[C@@](C)(CO[Si](C)(C)C)N2,,ClCCl,,O,,val
US20150284375A1,CC(C)(C)OC(=O)NCc1ccc(CO)cc1.Oc1ccccc1>>CC(C)(C)OC(=O)NCc1ccc(COc2ccccc2)cc1,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05556858,CC(=O)Cl.NCCN1CCC(c2noc3cc(F)ccc23)CC1.O=C(O)/C=C/C(=O)O>>CC(CC(N)=O)N1CCC(c2noc3cc(F)ccc23)CC1.O=C(O)/C=C/C(=O)O,,CCO,ClCCl,CCN(CC)CC,,val
US04281019,CCCCCCCCCC=CCCCNc1ccc(C(=O)Cl)cc1.CCOC(=O)CC(=O)OCC>>CCCCCCCCCC=CCCCNc1ccc(C(=O)C(C(=O)OCC)C(=O)OCC)cc1,,COCCOC,,Cl,[H-].[Na+],val
US20040235822A1,COc1cc([N+](=O)[O-])ccc1S>>COc1cc(N)ccc1S,,CC(=O)O,,,,val
US20060058287A1,CC1(C)OC(=O)CC(=O)O1.COC(OC)OC.N#Cc1ccc(N)cc1>>CC1(C)OC(=O)C(=CNc2ccc(C#N)cc2)C(=O)O1,,CCO,,,,val
US05491132,CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CC(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CC(C1CCCCC1)C1CCCCC1,O=[Pt],CC(=O)O,,[H][H],,val
US04474963,C=CCOCC1CO1.O>>C=CCOCC(O)CO,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20150239842A1,CC(C)O.COC(=O)c1cc(-c2cnn(C)c2)cc(F)c1Cl>>CC(C)Oc1cc(-c2cnn(C)c2)cc(C(=O)O)c1Cl,,CC(C)O,,CC(C)(C)[O-].[K+],,val
US20020032208A1,COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1O.ClCCCOc1ccncc1>>COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCCOc1ccncc1,,CN1CCCC1=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20020052392A1,COc1ccc(/C(C=O)=C/O)cc1.NO>>COc1ccc(-c2cnoc2)cc1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US05574178,CC(C)(C)c1cc2occc2c(C(C)(C)C)c1O>>CC(C)(C)c1cc2c(c(C(C)(C)C)c1O)CCO2,[Pd],CC(=O)O,,,,val
US06075036,CCc1c(-c2ccc(OC)cc2)cn2ccc(OC)cc12.COC(=O)C#CC(=O)OC>>CCc1c(-c2ccc(OC)cc2)c2c(C(=O)OC)c(C(=O)OC)c3cc(OC)cc1n32,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20110301155A1,Cc1ccc(S(=O)(=O)OCCS(C)(=O)=O)cc1.O=[N+]([O-])c1cc[nH]n1>>CS(=O)(=O)CCn1ccc([N+](=O)[O-])n1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04049807,Cl.NC(N)=S.O=C(CCCl)c1ccccc1>>Cl.NC1N=C(c2ccccc2)C=CS1,,CCO,Cl,O,,val
US20100324068A1,CCOC(=O)C(C(=O)OCC)c1cc(Cl)c(OC)cc1Cl>>COc1cc(Cl)c(CC(=O)O)cc1Cl,,C1CCOC1,CCO,[Na+].[OH-],,val
US20030114437A1,CCC=O.C[C@@H]1CC[C@H](NC(=O)[C@H](CC2CCCCC2)NC(=O)OC(C)(C)C)[C@@H](O)CN1>>CCCN1C[C@H](O)[C@@H](NC(=O)[C@H](CC2CCCCC2)NC(=O)OC(C)(C)C)CC[C@H]1C,,ClCCl,,[BH4-].[Na+],,val
US20120208828A1,ClCc1nnc(-c2ccc(Cl)cc2Cl)o1.Sc1nnc(-c2ccncc2)n1-c1ccccc1Cl>>Clc1ccc(-c2nnc(CSc3nnc(-c4ccncc4)n3-c3ccccc3Cl)o2)c(Cl)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US07479536B1,CC(C)(C)OC(=O)N=[N+]=[N-].NCCO>>CC(C)(C)OC(=O)NCCO,,C1COCCO1,O,[Na+].[OH-],,val
US20110257100A1,O=C(Nc1ccc(Oc2ccnc3cc(-c4ccc(CN5CCNCC5)cn4)sc23)c(F)c1)NC1CC1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>O=C(Nc1ccc(Oc2ccnc3cc(-c4ccc(CN5CCN(CC(F)(F)F)CC5)cn4)sc23)c(F)c1)NC1CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US04275198,C=CC(=O)OC.CC(C)C=O.C[C@H](N)[C@H](O)c1ccccc1>>COC(=O)CCN1C(C)C(c2ccccc2)OC1C(C)C,,Cc1ccccc1,,,,val
US20080090845A1,COC(=O)CCCC(F)F>>O=C(O)CCCC(F)F,,CO,O,[K+].[OH-],,val
US20090062322A1,CC(C)(C)OC(=O)N1CCC(=O)C(F)C1.Fc1ccc(Cl)cc1CBr>>CC(C)(C)OC(=O)N1CCC(O)(Cc2cc(Cl)ccc2F)C(F)C1,,CCOCC,CCOCC,[Mg],,val
US20100280013A1,BrCc1ccccc1.COC(=O)c1ccc(N2CCN(CCO)CC2)c(Br)c1>>COC(=O)c1ccc(N2CCN(CCOCc3ccccc3)CC2)c(Br)c1,,CN(C)C=O,,O,[H-].[Na+],val
US20100010035A1,Br.Nc1ccc(C(=O)O)cc1O>>O=C(O)c1ccc(Br)c(O)c1,Br[Cu]Br,O,,O=N[O-].[Na+],,val
US20040019035A1,COC(=O)c1ccc(OC)cc1Oc1ccccc1[N+](=O)[O-]>>COC(=O)c1ccc(OC)cc1Oc1ccccc1N,[Pd],CCO,CO,,,val
US20110269738A1,CC(C)O.Fc1ccc(Br)cc1C(F)(F)F>>CC(C)Oc1ccc(Br)cc1C(F)(F)F,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20020103192A1,CNC(=O)C(=O)CCCCCCC(=O)OCc1ccccc1>>CNC(=O)C(=O)CCCCCCC(=O)O,[Pd],CO,,,,val
US20090311217A1,CCCC[Sn](CO)(CCCC)CCCC.COc1ccc2c(c1)c(/C=C1\Oc3cc(Br)ccc3C1=O)cn2CCCN(C)C>>COc1ccc2c(c1)c(/C=C1\Oc3cc(CO)ccc3C1=O)cn2CCCN(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,C1COCCO1,,val
US20150072969A1,CCOC(=O)CC1(c2ccc(OCc3cccc(-c4ccc(OCC5(C)COC5)cc4Cl)c3)cc2)COC1>>CC1(COc2ccc(-c3cccc(COc4ccc(C5(CC(=O)O)COC5)cc4)c3)c(Cl)c2)COC1,,C1CCOC1,CO,O,[Li+].[OH-],val
US20150023913A1,CI.O=C1CCCOC1C(=O)OCc1ccccc1>>CC1(C(=O)OCc2ccccc2)OCCCC1=O,,CCOCC,O,CN(C)C=O,[H-].[Na+],val
US20110245274A1,FC(F)(F)C1(c2cc(Cl)cc(Cl)c2)CC(c2ccc(-c3cn[nH]c3)c3ccccc23)=NO1.FC(F)(F)CI>>FC(F)(F)Cn1cc(-c2ccc(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)c3ccccc23)cn1,,CN(C)C=O,,O,[H-].[Na+],val
US20160251339A1,C=O.COc1c(N2CCNCC2)cc(S(=O)(=O)n2cc(C(F)F)c3ccc(Cl)cc32)c2ccccc12>>COc1c(N2CCN(C)CC2)cc(S(=O)(=O)n2cc(C(F)F)c3ccc(Cl)cc32)c2ccccc12,,CO,,[BH3-]C#N.[Na+],,val
US20110152282A1,Brc1cccc2c1CCNC2.C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O>>CC1(C)OC[C@H](CN2CCc3c(Br)cccc3C2)O1,,CCOC(C)=O,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100280067A1,CN(C)C=O.FC(F)(F)Oc1cc(Br)ccc1OCC1CC1>>O=Cc1ccc(OCC2CC2)c(OC(F)(F)F)c1,,C1CCOC1,,[Li]CCCC,,val
US20090143355A1,CS(=O)(=O)NCCOc1cc([N+](=O)[O-])cc(C(F)(F)F)c1>>CS(=O)(=O)NCCOc1cc(N)cc(C(F)(F)F)c1,[Pd],CO,,,,val
US20040063768A1,CNC.O=C[C@H]1CCC[C@@H]1c1c[nH]c2ccc(I)cc12>>CN(C)C[C@@H]1CCC[C@H]1c1c[nH]c2ccc(I)cc12,,C1CCOC1,CO,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20090163485A1,CC(C)(C)c1ccc(N)c(N)c1.CCOC(=O)C=O>>CC(C)(C)c1ccc2nc(O)cnc2c1,,CCO,,,,val
US20110092505A1,Brc1cccc(Br)n1.CC(C)(C)OC(=O)NC1CCNCC1>>CC(C)(C)OC(=O)NC1CCN(c2cccc(Br)n2)CC1,,ClCCl,,,,val
US04939172,CI.Cc1c(F)c(F)c(C=O)c(F)c1F>>CC(O)c1c(F)c(F)cc(F)c1F,,CCOCC,,[Mg],[Cl-].[NH4+],val
US20140094445A1,COC(=O)c1cnc(Cl)c(Br)c1.NN>>NNC(=O)c1cnc(Cl)c(Br)c1,,CO,,,,val
US20110027718A1,CC(C)(C)OC(=O)N1CCC(O)CC1.COCCOCCl>>COCCOCOC1CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20090202480A1,C=C[C@@H]1C[C@]1(NC(=O)n1ccnc1)C(=O)OCC.CI>>C=C[C@@H]1C[C@]1(NC(=O)n1cc[n+](C)c1)C(=O)OCC.[I-],,CC#N,,,,val
US20020119992A1,CCOC(=O)/C=C/c1cccc(C(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)c1cccc(/C=C/C(=O)O)c1,,CCO,,[Na+].[OH-],,val
US20050222410A1,CC(C)(C)OC(=O)N1CCN(c2ccc(C(=O)O)s2)CC1.CC(C)(C)OC(=O)Nc1ccccc1N>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)s1,,ClCCl,,CCN(CC)CC,,val
US06252070B1,CCc1cc(Br)cc(C=O)c1O.OO>>OCCc1cc(O)cc(Br)c1,,C1CCOC1,,[Na+].[OH-],,val
US04357471,C1=NCCCC12CCCCC2>>C1CCC2(CC1)CCCNC2,[Ni],CCO,,[H][H],,val
US20090143372A1,CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(Br)cc23)CC1.OB(O)c1cccc(-n2cccn2)c1>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(-n5cccn5)c4)cc23)CC1,,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20080262063A1,COc1ccc(N=C=O)cc1OC.Nc1ccc2[nH]cnc2c1>>COc1ccc(NC(=O)Nc2ccc3[nH]cnc3c2)cc1OC,,C1CCOC1,,,,val
US20070249639A1,O=[N+]([O-])c1ccc2nc(OCCN3CCOCC3)sc2c1>>Nc1ccc2nc(OCCN3CCOCC3)sc2c1,,CCO,,,,val
US05066680,CCN.O=C(NCC#CCCl)C(O)(c1ccccc1)c1ccccc1>>CCNCC#CCNC(=O)C(O)(c1ccccc1)c1ccccc1,,CO,,,,val
US20120028961A1,Cc1ccccc1.N#Cc1ccc(C(=O)Cl)cc1>>Cc1ccc(C(=O)c2ccc(C#N)cc2)cc1,,CCOCC,Cc1ccccc1,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20040002488A1,C=O.c1ccc2sccc2c1>>OCc1cc2ccccc2s1,,C1CCOC1,,Cl,[Li]CCCC,val
US04820705,CCOC(=O)C1C=C(c2ccc3c(c2)CC(NS(=O)(=O)c2ccc(C)cc2)C3)NNC1=O>>Cc1ccc(S(=O)(=O)NC2Cc3ccc(C4=NNC(=O)CC4)cc3C2)cc1,,CCO,O,[Na+].[OH-],,val
US20090170926A1,CC1(C)CCc2c(ccc3c2C(=O)C(Cl)=CC3=O)O1.ClCl>>CC1(C)CCc2c(ccc3c2C(=O)C(Cl)=C(Cl)C3=O)O1,Cl,CC(=O)O,,,,val
US20140308282A1,CC(C)CCn1c(CNc2ccccc2C(=O)NC2(C(=O)O)CC2)nc2ccccc21>>CC(C)CCn1c(CN2C(=O)C3(CC3)NC(=O)c3ccccc32)nc2ccccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20160039812A1,CI.N#Cc1ccc(C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)NCC3)c(C(F)(F)F)c1>>CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)NCC2)C1c1ccc(C#N)cc1C(F)(F)F,,CC#N,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04360680,C=CC#N.Cc1ccc(NN)cc1>>Cc1ccc(N2CCC(N)=N2)cc1,,CCO,,Cl,[Na],val
US20100190778A1,COc1cccc2c1S(=O)(=O)NN=C2C>>COc1cccc2c1S(=O)(=O)NNC2C,O=[Pt]=O,,,,,val
US20160220572A1,COc1ccc(F)c(-c2nc(NC(C)C)nc(NC(C)(C)C#N)n2)c1>>CC(C)Nc1nc(NC(C)(C)C#N)nc(-c2cc(O)ccc2F)n1,,ClCCl,,BrB(Br)Br,,val
US20110092485A1,CCCN(CCCO[Si](C)(C)C(C)(C)C)C(=O)C1=Cc2ccc(-c3ccc(CC(=O)OCCF)cc3)cc2N=C(NC(=O)OC(C)(C)C)C1>>CCCN(CCCO)C(=O)C1=Cc2ccc(-c3ccc(CC(=O)OCCF)cc3)cc2N=C(N)C1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100305096A1,CC(C)(C)OC(=O)N1CC[C@H](C(=O)N2CCCC2)C1>>O=C([C@H]1CCNC1)N1CCCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120010182A1,O=C1CCC(=O)N1I.Oc1ccc(Cl)c(-c2cccc(F)c2)c1>>Oc1cc(-c2cccc(F)c2)c(Cl)cc1I,,CC(=O)O,ClCCl,O=S(=O)(O)O,,val
US20100189773A1,C[C@@H](NC(=O)OC(C)(C)C)[C@H]1CC[C@H](N)CC1.C[C@@H](O)C(=O)O>>C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1CC[C@@H](NC(=O)[C@@H](C)O)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20060211717A1,CC(O)c1ccccc1F.COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)OC(C)c4ccccc4F)cc3)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US05665718,CC1(C)CCCNC1.CN1Cc2c(-c3noc(CCl)n3)ncn2-c2ccccc2C1=O>>CN1Cc2c(-c3noc(CN4CCCC(C)(C)C4)n3)ncn2-c2ccccc2C1=O,,CN(C)C=O,,,,val
US06177423B1,CC(=O)O.Nc1cc(Cl)c2c(Cl)ccc3c2c1CC3>>CC(=O)Nc1cc(Cl)c2c(Cl)ccc3c2c1CC3,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20160130268A1,O=C(O)Cc1ccc([N+](=O)[O-])c(F)c1>>O=[N+]([O-])c1ccc(CCO)cc1F,,C1CCOC1,,B,CSC,val
US20060089359A1,CN.O=C(O)c1ccc(-n2nc(Br)c3ccccc3c2=O)cc1>>CNC(=O)c1ccc(-n2nc(Br)c3ccccc3c2=O)cc1,,C1CCOC1,CN(C)C=O,O=C(n1ccnc1)n1ccnc1,,val
US20090306066A1,COC(=O)C1C(=O)C(=O)N(Cc2ccccc2)C1(C)C>>CC1(C)CC(=O)C(=O)N1Cc1ccccc1,,CC(=O)O,O,,,val
US20100048568A1,C#C[Si](C)(C)C.Nc1ncc(F)cc1I>>C[Si](C)(C)C#Cc1cc(F)cnc1N,[Cu]I,C1CCOC1,,CCN(CC)CC,,val
US20070287711A1,CN(C)C(=O)c1cc(-c2cnc3c(c2)c(Cc2cccc(Cl)c2)nn3COC(=O)C(C)(C)C)ccc1N.O=C(Cl)N1CCOCC1>>CN(C)C(=O)c1cc(-c2cnc3c(c2)c(Cc2cccc(Cl)c2)nn3COC(=O)C(C)(C)C)ccc1NC(=O)N1CCOCC1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20160096834A1,CC[Mg]Br.N#Cc1ccc(Br)cc1F>>NC1(c2ccc(Br)cc2F)CC1,,CCOCC,,FB(F)F,,val
US20080227812A1,C=O.CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(NCC6CC6)CC5)c(OC)cc34)ccc12>>CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(N(C)CC6CC6)CC5)c(OC)cc34)ccc12,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080167378A1,CCO.CCOC(=O)CCc1ccc(OCc2c(C)cc(C)cc2C)c(F)c1>>CCCCCC.CCOC(C)=O,,CCO,,Cl,[Na+].[OH-],val
US20130096138A1,CC(C)(C)c1ccc(CN)cc1.Nc1cccc2c(O)cccc12.S=C(Cl)Cl>>CC(C)(C)c1ccc(CNC(=S)Nc2cccc3c(O)cccc23)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20100168094A1,COc1cc([N+](=O)[O-])c(Br)cc1C1CCCC1>>COc1cc(N)c(Br)cc1C1CCCC1,[Zn],CC(=O)O,CCOC(C)=O,O,,val
US20050032838A1,CSc1ccc(O)cc1.O=C(N[C@@H]1CC[C@@H](O)CC1)c1cc(F)cnc1Cl>>CSc1ccc(Oc2ncc(F)cc2C(=O)N[C@@H]2CC[C@@H](O)CC2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150353540A1,COC(=O)c1cc2cc(NCc3cc(NC(=O)c4ccc(CN5CCN(C)CC5)c(C(F)(F)F)c4)ccc3C)cnc2[nH]1>>Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1CNc1cnc2[nH]c(C(=O)O)cc2c1,,CO,O,[K+].[OH-],,val
US20080227782A1,CCOC(=O)C(=CN(C)C)C(C)=O.N=C(N)c1ccc(F)cc1>>CCOC(=O)c1cnc(-c2ccc(F)cc2)nc1C,,CCO,,Cl,[Na],val
US20110112110A1,Brc1ccc(I)nc1.C[Sn](C)(C)c1nccs1>>Brc1ccc(-c2nccs2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20030171418A1,C[C@@H](Cn1ncc2ccc3c(c21)C(N=[N+]=[N-])C(Br)CO3)NC(=O)OCc1ccccc1>>C[C@H](N)Cn1ncc2ccc3c(c21)C(N)C(O)CO3,[Pd],,,CO,,val
US04962203,Cc1ccc2ccccc2n1.O=Cc1cccc([N+](=O)[O-])c1>>O=[N+]([O-])c1cccc(C=Cc2ccc3ccccc3n2)c1,,CC(=O)OC(C)=O,,,,val
US20090093456A1,BrBr.COc1ccccc1N1CCNCC1>>COc1cc(Br)ccc1N1CCNCC1,,ClCCl,,,,val
US20080021022A1,COc1ccccc1-c1oncc1C(=O)O.c1ccc(C2CCNC2)cc1>>COc1ccccc1-c1oncc1C(=O)N1CCC(c2ccccc2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20020049234A1,COc1ccc(C(=O)Nc2cnccc2NC(=O)OC(C)(C)C)cc1>>COc1ccc(C(=O)Nc2cnccc2N)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05068320,CCCCCCC(=O)Cl.OC[C@@H]1CC[C@H](n2cnc3c(NCC4CC4)ncnc32)O1>>CCCCCCC(=O)OC[C@@H]1CC[C@H](n2cnc3c(NCC4CC4)ncnc32)O1,CN(C)c1ccncc1,CC#N,,CCN(CC)CC,,val
US20160168090A1,NC(=O)Cn1cc(C(=O)O)c2c(Cl)ccnc21.NCC1CCC(F)(F)CC1>>NC(=O)Cn1cc(C(=O)NCC2CCC(F)(F)CC2)c2c(Cl)ccnc21,,C1CCOC1,,ClCCCl,On1nnc2ccccc21,val
US20040152893A1,Cc1cccc(O)c1.N#Cc1c(Cl)cccc1Cl>>Cc1cccc(Oc2cccc(Cl)c2C#N)c1,,CS(C)=O,,O,[H-].[Na+],val
US20080058356A1,CI.Nc1cc(-c2ccco2)nc(S)n1>>CSc1nc(N)cc(-c2ccco2)n1,,[Na+],[OH-],,,val
US20130245064A1,O=Cc1ccc(C(=O)O)cc1.O=S([O-])O.[Na+]>>O=C(O)c1ccc(C(O)S(=O)(=O)[O-])cc1.[Na+],,CCO,O,,,val
US20120309739A1,C1COCCN1.COc1nc(S(C)(=O)=O)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c12>>COc1nc(N2CCOCC2)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c12,,Cc1ccccc1,,,,val
US20090181928A1,CC1(C)OB(c2coc3ccccc23)OC1(C)C.O=C1CN(c2ccc(I)cc2OCc2ccccc2)S(=O)(=O)N1>>O=C1CN(c2cccc(-c3coc4cccc-4c3)c2OCc2ccccc2)S(=O)(=O)N1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160251340A1,Cc1cc(Oc2ccc(NC(=O)[C@@H](C)NC(=O)OC(C)(C)C)cc2)c2c(C)noc2c1>>Cc1cc(Oc2ccc(NC(=O)[C@@H](C)N)cc2)c2c(C)noc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04210753,C#CCOc1ccc(O)c2c1NC(=O)CC2.ClCC1CO1>>C#CCOc1ccc(OCC2CO2)c2c1NC(=O)CC2,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20070219186A1,CCOC(=O)c1cnn2c(-c3cccc(NC(=O)c4cc(NC(=O)CCl)cc(C(F)(F)F)c4)c3)ccnc12.CN1CCNCC1>>CCOC(=O)c1cnn2c(-c3cccc(NC(=O)c4cc(NC(=O)CN5CCN(C)CC5)cc(C(F)(F)F)c4)c3)ccnc12,,CN(C)C=O,,CCN(CC)CC,O,val
US04713486,CI.O=C(O)CCc1ccccc1Br>>COC(=O)CCc1ccccc1Br,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070208046A1,Ic1ccc(OC2CCCCO2)cc1.O=c1cc(OCc2ccccc2)cc[nH]1>>O=c1cc(OCc2ccccc2)ccn1-c1ccc(OC2CCCCO2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05885986,C=CCN(CC=C)Cc1csc(-c2ncn3c2CN(C)C(=O)c2cc(F)ccc2-3)n1.Cl>>C=CCN(CC=C)Cc1csc(-c2ncn3c2CN(C)C(=O)c2cc(F)ccc2-3)n1.Cl,,CCO,,,,val
US04935431,CCOC(=O)c1cnc2c(OC)csc2c1Cl.Cc1cc(O)ccc1N>>CCOC(=O)c1cnc2c(OC)csc2c1Nc1ccc(O)cc1C.Cl,,COc1ccccc1,,,,val
US20060292079A1,COCCn1ccc(C(=O)NC(CCCCNC(=O)OC(C)(C)C)C(=O)OC)c(OCc2ccccc2)c1=O>>COCCn1ccc(C(=O)NC(CCCCNC(=O)OC(C)(C)C)C(=O)O)c(OCc2ccccc2)c1=O,,CO,,Cl,[Na+].[OH-],val
US20060084640A1,CC(C)(C)OC(=O)N1CC=C(c2nc(Cl)c(-c3ccc(F)cc3)[nH]2)CC1>>Fc1ccc(-c2[nH]c(C3=CCNCC3)nc2Cl)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US04795483,CC(Sc1nc(SCc2ccccc2)n[nH]1)C(=O)O>>CC1Sc2nc(SCc3ccccc3)nn2C1=O,,CCOC(C)=O,,,,val
US20040260088A1,Br.COc1cccc(CN(C)C)c1SC>>Br.CSc1c(O)cccc1CN(C)C,,CCOCC,,CC(=O)O,,val
US20130053376A1,C[C@H](N)Cc1cc(F)ccc1Br.O=C1c2cc3[nH]c(-c4c(Cl)cc[nH]c4=O)nc3cc2CN1CCN1CCCC1>>C[C@@H](Cc1cc(F)ccc1Br)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(=O)N(CCN1CCCC1)C3,,CCO,,CCN(C(C)C)C(C)C,,val
US20140051692A1,COC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc3nn2c1N1CCC(C)(CC1)OCC=CC[C@H](C)Oc1ccc(C(F)(F)F)cc1-c1cccc-3c1>>COC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc3nn2c1N1CCC(C)(CC1)OCCCC[C@H](C)Oc1ccc(C(F)(F)F)cc1-c1cccc-3c1,[Pd],CO,,,,val
US05017568,COC(=O)C1=CC2CC[C@@H]3[C@H](CC[C@]4(C)[C@@H](C(=O)O)CC[C@@H]34)[C@@]2(C)CC1>>COC(=O)C1=CC2CC[C@H]3[C@@H]4CCC[C@@]4(C)CC[C@@H]3[C@@]2(C)CC1,,Cc1ccccc1,,O=C(Cl)C(=O)Cl,,val
US20070010548A1,CC1(C)CC(=O)CC(=O)C1.Cc1ccc(-n2nc(C(C)(C)C)cc2N)cc1.Cc1ccc(C=O)cc1>>Cc1ccc(C2C3=C(CC(C)(C)CC3=O)Nc3c2c(C(C)(C)C)nn3-c2ccc(C)cc2)cc1,,CCO,,,,val
US20080058321A1,CCOC(=O)c1ccc(S[C@@H](CCCc2ccc(OC)cc2)C(=O)N2C(=O)OC[C@H]2Cc2ccccc2)c([N+](=O)[O-])c1>>CCOC(=O)c1ccc2c(c1)NC(=O)[C@H](CCCc1ccc(OC)cc1)S2,[Pd],CC(=O)O,,CCO,,val
US04772600,CN(C)C(=O)Cn1c(-c2ccc(Cl)cc2)nc2cccnc21.O=C(OO)c1cccc(Cl)c1>>CN(C)C(=O)Cn1c(-c2ccc(Cl)cc2)nc2ccc[n+]([O-])c21,,O,,CC(=O)O,,val
US20020188120A1,CCOC(=O)C1(S(=O)(=O)c2ccc(OCCC(C)C)cc2)CCN(Cc2ccccc2)CC1>>CC(C)CCOc1ccc(S(=O)(=O)C2(C(=O)O)CCN(Cc3ccccc3)CC2)cc1,,C1CCOC1,,CO,[Na+].[OH-],val
US20110301150A1,O=C(n1ccnc1)n1ccnc1.OCc1cc(-c2ccc(OCc3ccccc3)cc2)no1>>O=C(OCc1cc(-c2ccc(OCc3ccccc3)cc2)no1)n1ccnc1,,C1CCOC1,,,,val
US20010037028A1,O=C(O)C(Cl)(Cl)Cl.O=C1C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F>>OC1(C(Cl)(Cl)Cl)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F,,CN(C)P(=O)(N(C)C)N(C)C,,,,val
US20150210644A1,CC(=O)Nc1ccc2ccc(CBr)cc2n1.NCCc1cccc(F)c1>>CC(=O)Nc1ccc2ccc(CNCCc3cccc(F)c3)cc2n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110218197A1,Cn1nc(C(C)(C)C)cc1C(=O)Cl.Nc1cc(Br)ncc1[N+](=O)[O-]>>Cn1nc(C(C)(C)C)cc1C(=O)Nc1cc(Br)ncc1[N+](=O)[O-],,C1CCOC1,,[H-].[Na+],,val
US20090197877A1,CCNC(=O)Nc1nc2cc(OS(=O)(=O)C(F)(F)F)cc(-c3ccc(C#N)cn3)c2s1.OB(O)c1cccnc1>>CCNC(=O)Nc1nc2cc(-c3cccnc3)cc(-c3ccc(C#N)cn3)c2s1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US05596002,C1CCNC1.C=O.CC(C)[N+](=O)[O-]>>CC(C)(CN1CCCC1)[N+](=O)[O-],,C1COCCO1,,[Na+].[OH-],,val
US20050119282A1,CC(=O)c1c(Cl)nc(N)nc1Cl.NN>>Cc1n[nH]c2nc(N)nc(Cl)c12,,ClCCl,,,,val
US20150266879A1,CC(C)[C@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(=O)N1c2ncccc2C[C@@H]1C(=O)Nc1ccccc1C(=O)c1ccccc1>>CN[C@@H](C)C(=O)N[C@H](C(=O)N1c2ncccc2C[C@@H]1C(=O)Nc1ccccc1C(=O)c1ccccc1)C(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090156610A1,O=Cc1cc(Br)ccc1F.Oc1ccc(C(F)(F)F)cc1>>O=Cc1cc(Br)ccc1Oc1ccc(C(F)(F)F)cc1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20150329538A1,Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1CCCN(C(=O)OC(C)(C)C)C1>>Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1CCCNC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04506103,Oc1ccccc1.c1ccc(COCc2ccccc2)cc1>>Oc1ccccc1Cc1ccccc1,,Cc1ccccc1,,O,,val
US20080262042A1,CN(Cc1cn(S(=O)(=O)c2cnn(C)c2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C.Cl>>CNCc1cn(S(=O)(=O)c2cnn(C)c2)c(-c2cccnc2F)c1F.Cl,,CC(C)O,,CCOC(C)=O,,val
US20080033002A1,CN(C)C(=O)C1=CCC2(CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21>>CN(C)C(=O)C1=CCC2(CCNCC2)c2ccccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US05747490,CC(C)(C)NC(=O)[C@@H]1CNCCN1C(=O)OCc1ccccc1.COc1cc2nc(Cl)nc(N)c2cc1OC>>COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC,,CC(C)O,,,,val
US20140288045A1,C=CC(=O)Cl.COc1cc(Cl)c(-c2ccccc2Cl)cc1NCC(=O)N1CCNCC1>>C=CC(=O)N1CCN(C(=O)CNc2cc(-c3ccccc3Cl)c(Cl)cc2OC)CC1,,ClCCl,,CCN(CC)CC,,val
US06441017B1,OC(c1cccc(Cl)c1)c1cccc(OCc2ccccc2)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=NC(c1cccc(Cl)c1)c1cccc(OCc2ccccc2)c1,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,,val
US20050009821A1,CC(CN)c1nsc(NC(=O)OC(C)(C)C)n1.CCCC(=O)Cl>>CCCC(=O)NCC(C)c1nsc(NC(=O)OC(C)(C)C)n1,,ClCCl,,CCN(CC)CC,,val
US20090221555A1,CC1(C)CCCNc2cc([N+](=O)[O-])ccc21.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CC1(C)CCCN(C(=O)Oc2ccc([N+](=O)[O-])cc2)c2cc([N+](=O)[O-])ccc21,CN(C)c1ccncc1,ClCCCl,,c1ccncc1,,val
US20150210722A1,CCP(=O)(CC)Cc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)c1.Cc1cc(N)cc2cn[nH]c12>>CCP(=O)(CC)Cc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(C)c5[nH]ncc5c4)n3)c3ccccc23)c1,,C1CCOC1,CN(C)C=O,Cl,,val
US05891909,COc1ccc(C)cc1S(=O)(=O)Oc1cc(C)cc(O)c1.OCCCO>>COc1ccc(C)cc1S(=O)(=O)Oc1cc(C)cc(OCCCO)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04319026,CN(N)c1nc(-c2ccccc2)cs1.O=C1OC(=O)c2ccccc21>>CN(NC(=O)c1ccccc1C(=O)O)c1nc(-c2ccccc2)cs1,,O,,CN(C)C=O,,val
US20130281490A1,C[C@H](O)[C@@H](NC(=O)OCCOCCc1ccccc1)C(=O)O>>C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCOCCc1ccccc1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20090023746A1,Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(CC3CC3)cc(C(=O)O)c2c1.N[C@@H]1CCNC1>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(CC3CC3)cc(C(=O)N3CC[C@@H](N)C3)c2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US07179823B1,CCOC(=O)c1cn(Cc2ccc(Oc3ccccc3)cc2)nc1O.Cc1oc(-c2ccccc2)nc1CCl>>CCOC(=O)c1cn(Cc2ccc(Oc3ccccc3)cc2)nc1OCc1nc(-c2ccccc2)oc1C,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100234441A1,CCNCC(O)(CNC(=O)c1cnn(-c2ccc(F)cc2)c1N)C(F)(F)F.O=C(Cl)c1c(F)cccc1Cl>>CCN(CC(O)(CNC(=O)c1cnn(-c2ccc(F)cc2)c1N)C(F)(F)F)C(=O)c1c(F)cccc1Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150031674A1,CSc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(CC3CO3)c2n1.[N-]=[N+]=[N-]>>CSc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(CC(O)CN=[N+]=[N-])c2n1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20050014758A1,O=C(Cl)C(=O)Cl.O=C(O)c1cn(-c2ccc3ccccc3n2)c2ncccc12>>Cl.O=C(Cl)c1cn(-c2ccc3ccccc3n2)c2ncccc12,,ClCCl,,,,val
US20140228405A1,CC(C)(C)OC(=O)N(CC1CC1)[C@@H]1C[C@H]1c1ccc(N)cc1.O=C1OC(=O)c2ccccc21>>CC(C)(C)OC(=O)N(CC1CC1)[C@@H]1C[C@H]1c1ccc(N2C(=O)c3ccccc3C2=O)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20130309200A1,COc1ncccc1Nc1nc(N[C@@H](C)c2ccc(F)cn2)ccc1N.N=CN>>COc1ncccc1-n1cnc2ccc(N[C@@H](C)c3ccc(F)cn3)nc21,,CCO,CCOC(C)=O,CC(=O)O,,val
US05284849,C=C[C@H]1OC(C)(C)O[C@H]1CC(C)C.O=[O+][O-]>>CC(C)C[C@@H]1OC(C)(C)O[C@H]1C=O,,ClCCl,,,,val
US20050153408A1,COc1ccc2c(c1)C[C@H](OS(=O)(=O)c1cccc([N+](=O)[O-])c1)CC2.N>>COc1ccc2c(c1)C[C@@H](N)CC2,,CO,,,,val
US05525742,CCC(C)(C)N.N#CN=C(Nc1cc(I)cc(N=[N+]=[N-])c1)Oc1ccccc1>>CCC(C)(C)N=C(NC#N)Nc1cc(I)cc(N=[N+]=[N-])c1,,CC(C)O,,,,val
US20110319378A1,CCC(CC)N1C(=O)[C@@](C)(CC(N)=NO)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1.O=C(n1ccnc1)n1ccnc1>>CCC(CC)N1C(=O)[C@@](C)(Cc2noc(=O)[nH]2)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1,,C1COCCO1,,C1CCC2=NCCCN2CC1,,val
US04587238,CC(C)(C)OC(=O)CI.O=C1NCCCCCCC1Br>>CC(C)(C)OC(=O)CN1CCCCCCC(Br)C1=O,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20100304149A1,CN(C)c1ccc(C(=O)O)cc1.OCCCl>>CN(C)c1ccc(C(=O)OCCO)cc1,,CC(=O)N(C)C,,[H-].[Na+],,val
US04898871,CC(C)CNC(=O)CO.O=C1c2ccccc2C(Cl)N1c1ccc2ccc(Cl)nc2n1>>CC(C)CNC(=O)COC1c2ccccc2C(=O)N1c1ccc2ccc(Cl)nc2n1,,C1CCOC1,,[H-].[Na+],,val
US05990156,CCCN(CCC)C(=O)[C@@H]1OC(C(=O)OC)=C[C@@H](N=[N+]=[N-])[C@H]1NC(C)=O>>CCCN(CCC)C(=O)[C@@H]1OC(C(=O)O)=C[C@@H](N)[C@H]1NC(C)=O,,C1CCOC1,O,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120208819A1,COC(=O)c1cccc(I)c1CBr.N>>O=C1NCc2c(I)cccc21,,CO,,,,val
US20130090340A1,CC(C)(C)OC(=O)N1CCn2c(C#N)c(-c3cccc(F)c3)c(C(=O)n3ccnc3)c2C1>>CC(C)(C)OC(=O)N1CCn2c(C#N)c(-c3cccc(F)c3)c(C(N)=O)c2C1,,O,,N,,val
US20070203159A1,COc1ccc(Cn2cnc3c(-c4ccco4)nc([N+](=O)[O-])nc32)cc1.Oc1ccccc1>>COc1ccc(Cn2cnc3c(-c4ccco4)nc(Oc4ccccc4)nc32)cc1,,ClCCl,,[F-].[K+],,val
US04927822,CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1N=C(c2ccc(SC)cc2)S[C@H]1C(=O)O.S>>CSc1ccc(C(=S)SCC(=O)O)cc1,,CO,,,,val
US20160038504A1,O=C([O-])c1ccnc(C(F)F)c1>>O=C(O)c1ccnc(C(F)F)c1,,C1CCOC1,,[Li+].[OH-],,val
US20030149019A1,C1CNCCN1.CCNc1cc(F)ccc1[N+](=O)[O-]>>CCNc1cc(N2CCNCC2)ccc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150126539A1,CCOC(CN(CC)CC)OCC.O=S([O-])O.[Na+]>>CCN(CC)CC(O)S(=O)(=O)[O-].[Na+],,O,,CCO,Cl,val
US20150259323A1,CCOc1ccccc1O[C@@H]1CCCN(c2ncc(C(=O)OC)cc2F)C1>>CCOc1ccccc1O[C@@H]1CCCN(c2ncc(C(=O)O)cc2F)C1,,C1CCOC1,O,[Li+].[OH-],,val
US20050014749A1,CC(C)(C)[Si](C)(C)OCCn1ncc2c1CCCC2=O>>CC(C)(C)[Si](C)(C)OCCn1ncc2c1CCCC2O,,CO,,[BH4-].[Na+],,val
US20160016948A1,C1=COCCC1.C[C@H](n1c(CO)nc2cnc(Cl)cc21)C(F)(F)F>>C[C@H](n1c(COC2CCCCO2)nc2cnc(Cl)cc21)C(F)(F)F,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100298267A1,CCc1ncccc1C(=O)Nc1c(Cl)ncnc1NC1CC1.OB(O)c1ccc(Cl)cc1Cl>>CCc1ncccc1C(=O)Nc1c(NC2CC2)ncnc1-c1ccc(Cl)cc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20100317068A1,CSCCC(N)C(=O)O.O=C(Cl)c1ccccc1>>CSCC[C@H](NC(=O)c1ccccc1)C(=O)O,,O,,[Na+].[OH-],,val
US20100197651A1,CN(C)C=CC(=O)c1nn(-c2ccccc2N2CCOCC2)ccc1=O.NNc1ccccc1>>O=c1ccn(-c2ccccc2N2CCOCC2)nc1-c1ccnn1-c1ccccc1,,CO,,,,val
US20080009638A1,CCOC(=O)CCCN[C@@H](CC)C(N)=O>>CC[C@@H](C(N)=O)N1CCCC1=O,,Cc1ccccc1,,,,val
US20020151503A1,CP(=O)(CC(CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1)OCc1ccccc1>>CP(=O)(O)CC(CCC(=O)O)C(=O)O,[Pd],O,,,,val
US20050175682A1,CCCCCCCCCCCCCCOCC(COS(C)(=O)=O)OCCCCCCCCCCCCCC.O=C1NC(=O)c2ccccc21>>CCCCCCCCCCCCCCOCC(CN1C(=O)c2ccccc2C1=O)OCCCCCCCCCCCCCC,,CN(C)C=O,,[K],,val
US05117057,BrCc1ccccc1.CC(C)(C)N(NC(=O)c1ccccc1)C(=O)c1ccccc1>>CC(C)(C)N(C(=O)c1ccccc1)N(Cc1ccccc1)C(=O)c1ccccc1,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20070066624A1,Cc1nc(Oc2ccc(C(=O)OC(C)(C)C)cc2)ccc1CN1CCC(N2C(=O)N(C3CCCC3)C[C@H]2CC(C)C)CC1>>Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCCC3)C[C@H]2CC(C)C)CC1,,C1CCOC1,,Cl,,val
US20090163709A1,Brc1ccc2cc(OCc3ccccc3)ccc2c1.COc1ccc(CN)cc1>>COc1ccc(CNc2ccc3cc(OCc4ccccc4)ccc3c2)cc1,,CS(C)=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20150322089A1,COc1ncc2nc(N=C(SC)SC)sc2n1.NCC1(N)CN2CCC1CC2>>COc1ncc2nc(NC3=NC4(CN3)CN3CCC4CC3)sc2n1,,CN(C)C=O,,,,val
US20160176817A1,C[C@@H](N)C(F)(F)F.Cc1cc(NC(=O)c2cc(C(=O)C(=O)O)cn2C)ccc1F>>Cc1cc(NC(=O)c2cc(C(=O)C(=O)N[C@H](C)C(F)(F)F)cn2C)ccc1F,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090124618A1,C[C@H](c1ccccc1)N1CCO[C@@H](c2ccc(C(=O)O)cc2)C1.NCCO>>C[C@H](c1ccccc1)N1CCO[C@@H](c2ccc(C(=O)NCCO)cc2)C1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20120034270A1,O=[N+]([O-])/C=C/c1ccc(OCc2cccc(F)c2)cc1>>NCCc1ccc(OCc2cccc(F)c2)cc1,[Pd],CCO,,Cl,,val
US20100174065A1,COC(=O)c1cc(Br)ccc1OCCNC(=O)OC(C)(C)C>>O=C1NCCOc2ccc(Br)cc21,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US04012513,COc1ccc2c(c1)C(CC(=O)O)C(C)N2c1ccnc2cc(Cl)ccc12>>COc1ccc2c(c1)c(CC(=O)O)c(C)n2-c1ccnc2cc(Cl)ccc12,,Cc1ccccc1C,,,,val
US20150252030A1,COC(=O)COc1cccc(-c2ccco2)c1.NN>>NNC(=O)COc1cccc(-c2ccco2)c1,,CCO,,,,val
US20030134867A1,O=C(Cl)C(=O)Cl.O=C(O)c1ccnc(Oc2ccccc2)n1>>O=C(Cl)c1ccnc(Oc2ccccc2)n1,CN(C)C=O,ClCCl,,,,val
US05633276,CC(=O)NCCN1CCc2ccc3c(c21)CCO3.Cl>>CC(=O)NCCN1CCc2ccc3c(c21)CCO3.Cl,,CCOC(C)=O,,,,val
US06127414,O=C(NCCC[C@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CO)c1ccccc1)OCc1ccccc1>>NCCC[C@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CO)c1ccccc1,[Pd],CO,Cl,,,val
US20070078120A1,CCOC(=O)C(Br)CCC(Br)C(=O)OCC.COc1ccccc1N>>CCOC(=O)[C@H]1CC[C@@H](C(=O)OCC)N1c1ccccc1OC,,Cc1ccccc1,,,,val
US20130079341A1,COC(=O)c1cc([N+](=O)[O-])c(Cl)s1.COc1ccc(CN)c(OC)c1>>COC(=O)c1cc([N+](=O)[O-])c(NCc2ccc(OC)cc2OC)s1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US06177452B1,O=C(O)CCc1oc(Cl)nc1-c1ccc(Cl)cc1.Oc1ccccc1>>O=C(O)CCc1oc(Oc2ccccc2)nc1-c1ccc(Cl)cc1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US05530019,CCCCCCC(=O)Cl.c1ccc2[nH]ccc2c1>>CCCCCCC(=O)c1c[nH]c2ccccc12,,CCOC(C)=O,ClCCl,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20060004011A1,CC(C)(C)OC(=O)n1ccc2cc(OCc3ccccc3)ccc21>>CC(C)(C)OC(=O)n1ccc2cc(O)ccc21,[Pd],CCO,,O=C[O-].[NH4+],,val
US20060276450A1,C=CCN.COc1ccc2c(Cl)nc(C#N)c(-c3ccccc3)c2c1>>C=CCNc1nc(C#N)c(-c2ccccc2)c2cc(OC)ccc12,,CCCCO,,,,val
US05521147,CC1(C)Oc2c(N)ccc(Cl)c2C1=S.O=C(Cl)OC(Cl)(Cl)Cl>>CC1(C)Oc2c(N=C=O)ccc(Cl)c2C1=S,,Cc1ccccc1,,,,val
US20140128372A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC(O)COc1ccc(F)cc1>>CC(C)(C)OC(=O)NCC(O)COc1ccc(F)cc1,,ClCCl,,CCN(CC)CC,,val
US20150011541A1,CCOC(=O)C1CCCCN1.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1>>CCOC(=O)C1CCCCN1S(=O)(=O)c1cccc([N+](=O)[O-])c1,,CN(C)C=O,,CCN(CC)CC,,val
US20140275120A1,CI.O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(ncnc2-c2ccn[nH]2)C1>>Cn1ccc(-c2ncnc3c2CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)C3)n1,,CN(C)C=O,O,[H-].[Na+],,val
US20040044041A1,N#Cc1ccc(-c2ccccc2C(F)F)cc1>>NCc1ccc(-c2ccccc2C(F)F)cc1,[Ni],CO,N,,,val
US20120264749A1,COC(=O)c1ccc(S(=O)(=O)C2CCOC2)cc1>>O=C(O)c1ccc(S(=O)(=O)C2CCOC2)cc1,,C1COCCO1,,[Na+].[OH-],,val
US20030149051A1,COC(=O)CC(C)=O.ON=C(Cl)c1ccccc1>>COC(=O)c1c(-c2ccccc2)noc1C,,CCO,ClCCl,CCN(CC)CC,CCOC(C)=O,val
US20140066488A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCC[C@H](O)[C@H](N=[N+]=[N-])C(=O)OCC>>CCC[C@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)OCC,[Pd],CCO,,,,val
US20120220589A1,COC(=O)c1ccc2[nH]c(=O)c(Cl)nc2c1.Fc1cccc2c1CCCN2>>COC(=O)c1ccc2[nH]c(=O)c(N3CCCc4c(F)cccc43)nc2c1,,CN1CCCC1=O,,,,val
US07074819B2,COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2CCCCOCCCCN=[N+]=[N-])cc1>>COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2CCCCOCCCCN)cc1,[Pd],,,,,val
US07375227B2,Cc1cc(NC(=O)N[C@H](C(=O)N2CCC(Cc3ccccc3)CC2)C(C)C)c2ccccc2n1>>Cc1cc(NC(=O)N[C@H](CN2CCC(Cc3ccccc3)CC2)C(C)C)c2ccccc2n1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05130119,COC(=O)c1ccc(S(=O)(=O)Nc2c(F)cc(F)cc2F)cc1>>O=C(O)c1ccc(S(=O)(=O)Nc2c(F)cc(F)cc2F)cc1,,C1COCCO1,,[Na+].[OH-],,val
US20080085273A1,C/C=C(/C(=O)[O-])P(=O)(O)O.O=Cc1ccncc1.[Li]CCCC>>CCOC(=O)C=CC=Cc1ccncc1,,C1CCOC1,,CC(C)NC(C)C,,val
US20100305093A1,CCc1c(C(=O)O)ccc(S(C)(=O)=O)c1F.COC(=O)c1ccc2c(c1)CNCCO2>>CCc1c(C(=O)N2CCOc3ccc(C(=O)OC)cc3C2)ccc(S(C)(=O)=O)c1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120309738A1,CNc1cc(N2CCC(c3ccccc3)CC2)c(Cl)cc1N.O=C(NCc1ccc(Cl)c(N=C=S)c1)C1(C(F)(F)F)CC1>>Cn1c(Nc2cc(CNC(=O)C3(C(F)(F)F)CC3)ccc2Cl)nc2cc(Cl)c(N3CCC(c4ccccc4)CC3)cc21,,CN(C)C=O,O,CC(C)N=C=NC(C)C,,val
US05194619,C1=CCC=C1.CC(C)(C)C(=O)CCC(=O)C(C)(C)C>>CC(C)(C)c1ccc(C(C)(C)C)c2c1C=CC2,,CO,,C[O-].[Na+],,val
US20110152240A1,C1CCNC1.O=Cc1cnn2c(NC3CC3)cc(-c3csc(CBr)c3)nc12>>O=Cc1cnn2c(NC3CC3)cc(-c3csc(CN4CCCC4)c3)nc12,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20020173518A1,O=C(Nc1ccccc1[N+](=O)[O-])OCC1CCN(c2ccncc2)CC1>>Nc1ccccc1NC(=O)OCC1CCN(c2ccncc2)CC1,[Pd],CCO,,,,val
US06130239,COP(=O)(OC)C(=[N+]=[N-])C(C)=O.C[C@H]1OC(C)(C)N(C(=O)OC(C)(C)C)[C@@H]1C=O>>C#C[C@@H]1[C@@H](C)OC(C)(C)N1C(=O)OC(C)(C)C,,CCOC(C)=O,CO,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20090311217A1,COc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cn1cc(C=O)c2c(Br)cccc21>>COc1ccc(-c2cccc3c2c(C=O)cn3C)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20130109676A1,COC(=O)c1ccc(N2CCCCC2)c(C(F)(F)F)c1>>O=C(O)c1ccc(N2CCCCC2)c(C(F)(F)F)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20110112080A1,CC(C)(C)OC(=O)N1[C@@H](/C=C/c2ccc(I)cc2)COC1(C)C.O=C1NCCc2c1ccc(Cl)c2Cl>>CC(C)(C)OC(=O)N1[C@@H](/C=C/c2ccc(N3CCc4c(ccc(Cl)c4Cl)C3=O)cc2)COC1(C)C,[Cu]I,Cc1ccccc1,,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US04440929,CCOC(=O)c1ncn2c1c(=O)[nH]c1ccccc12.CI>>CCOC(=O)c1ncn2c1c(=O)n(C)c1ccccc12,O=[Ag],CN(C)C=O,,,,val
US20020103242A1,CCOC(=O)C1CCc2ccc(OCCCOc3ccc(OCC(F)(F)F)cc3Cl)cc2O1>>O=C(O)C1CCc2ccc(OCCCOc3ccc(OCC(F)(F)F)cc3Cl)cc2O1,,CC(C)O,,[Na+].[OH-],,val
US20150246063A1,COC(=O)c1ccc2cc(N[C@H]3CC[C@@H](C(F)(F)F)CC3)ccc2c1>>OCc1ccc2cc(N[C@H]3CC[C@@H](C(F)(F)F)CC3)ccc2c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080045521A1,COC(=O)[C@H](Cc1ccc(OCCCN(C(=O)OC(C)(C)C)c2ccc(OC)cn2)cc1)NC(=O)c1c(Cl)cccc1Cl>>COC(=O)[C@H](Cc1ccc(OCCCNc2ccc(OC)cn2)cc1)NC(=O)c1c(Cl)cccc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040254183A1,CC(C)Cn1c(NN)cc(=O)n(C)c1=O.O=Cc1ccccc1F.O=Cc1csc2ccccc12>>CC(C)Cn1c(=O)n(C)c(=O)c2c(-c3ccccc3F)n(Cc3csc4ccccc34)nc21,,CN(C)C=O,,C1CCNCC1,,val
US20060008671A1,CC(CN)c1ccccc1.O=C(Cl)c1ccccc1>>CC(CNC(=O)c1ccccc1)c1ccccc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US05256675,Nc1ccc(SCc2csc(N)n2)cc1.O=C(OO)c1cccc(Cl)c1>>Nc1ccc(S(=O)Cc2csc(N)n2)cc1,,CN(C)C=O,ClCCl,,,val
US20100016279A1,FC(F)(F)c1nnc2ccc(N3CC4CNCC4C3)nn12.O=C=Nc1ccc(F)cc1>>O=C(Nc1ccc(F)cc1)N1CC2CN(c3ccc4nnc(C(F)(F)F)n4n3)CC2C1,,Cc1ccccc1,,,,val
US03950522,C=CCNC(=S)Cc1ccccn1.Cl>>C=CCNC(=S)Cc1ccccn1.Cl,,CCOCC,,,,val
US20020161237A1,COC(=O)C(NC(=O)c1ccc(C(O)CCc2cccc(O)c2)cc1Cl)P(=O)(OC)OC.Cc1nc(C)c(C=O)s1>>COC(=O)/C(=C/c1sc(C)nc1C)NC(=O)c1ccc(C(O)CCc2cccc(O)c2)cc1Cl,,C1CCOC1,,CN(C)C(=N)N(C)C,,val
US20100256092A1,COCCl.OCC(c1ccccc1)c1ccccc1Br>>COCOCC(c1ccccc1)c1ccccc1Br,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06756388B1,Cc1cc(OCCCl)ccc1C(=O)O>>O=C(O)c1ccc(OCCCl)cc1,,CO,,[K+].[OH-],,val
US20120077828A1,Nc1nccc2occ(-c3ccc4c(c3F)CCN4)c12.O=C(O)Cc1cc(F)ccc1F>>Nc1nccc2occ(-c3ccc4c(c3F)CCN4C(=O)Cc3cc(F)ccc3F)c12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140336190A1,COc1ccc(C(O)(c2ccccn2)c2cc(-c3c(C)noc3C)cc3[nH]c(C4CC4)nc23)cn1>>Cc1noc(C)c1-c1cc(C(O)(c2ccc(O)nc2)c2ccccn2)c2nc(C3CC3)[nH]c2c1,,C1CCOC1,,Cl,,val
US20150299188A1,CC(C)(C)C(=O)Nc1ccnc(Cl)c1CNc1cc2c(cc1Cl)CCC(c1ncccc1F)O2>>O=C1Nc2ccnc(Cl)c2CN1c1cc2c(cc1Cl)CCC(c1ncccc1F)O2,,Cl,,[Na+].[OH-],,val
US20060247210A1,Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)Cl)cc2s1.NCCc1ccccc1>>Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)NCCc3ccccc3)cc2s1,,CO,,CN1CCOCC1,,val
US20020016339A1,CCOC(C)=O.CN(C)c1cccc2cccc(N(C)C)c12.O=C(Cl)OCc1ccccc1>>CC(=O)OCC1=CCCN(C(=O)OCc2ccccc2)C1,,ClCCl,,,,val
US20150038528A1,CC(C)(C)OC(=O)C(CNC(=O)c1ncc2cc(Oc3ccccc3)ccc2c1O)c1ccccc1>>O=C(NCC(C(=O)O)c1ccccc1)c1ncc2cc(Oc3ccccc3)ccc2c1O,,ClCCl,,O,O=C(O)C(F)(F)F,val
US20160108046A1,CC(C)(C)OC(=O)N1CC[C@H](CBr)C1.Cc1ccc(-c2nc3cc[nH]c3cc2-c2ccc(C#N)cc2)cc1>>Cc1ccc(-c2nc3ccn(C[C@H]4CCN(C(=O)OC(C)(C)C)C4)c3cc2-c2ccc(C#N)cc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020006944A1,CCOC(=O)CBr.O=C1CCCc2c(O)cccc21>>CCOC(=O)COc1cccc2c1CCCC2=O,,CN(C)C=O,O,[H-].[Na+],,val
US20060094750A1,CC(C)S(=O)(=O)c1cnc(Cl)c([N+](=O)[O-])c1.NCC1(O)CCOCC1>>CC(C)S(=O)(=O)c1cnc(NCC2CCOCC2)c([N+](=O)[O-])c1,,CCN(CC)CC,,Cl,,val
US05849911,COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(C(=O)OC(C)(C)C)C(N)c1ccc(-c2ccccn2)cc1)C(C)(C)C.Cl>>COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(N)Cc1ccc(-c2ccccn2)cc1)C(C)(C)C.Cl,,C1COCCO1,,CN(C)C=O,,val
US20140094459A1,CC(C)(C)OC(=O)N1CCC[C@@H](n2cc(I)c3c(N)ncnc32)C1.OB(O)c1ccc(Oc2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC[C@@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20150210697A1,CC(C)(C)OC(=O)N1CC(=O)C1.COc1ccc(CN(c2nc(Nc3cc(C#N)cc(N4CCNCC4)c3Cl)nn3c(C#N)cnc23)C2CC2)cc1>>COc1ccc(CN(c2nc(Nc3cc(C#N)cc(N4CCN(C5CN(C(=O)OC(C)(C)C)C5)CC4)c3Cl)nn3c(C#N)cnc23)C2CC2)cc1,,C1CCOC1,CO,CC(=O)O,[BH3-]C#N.[Na+],val
US06005000,Br[Mg]c1ccccc1.CC1(c2ccccc2)OC(=O)C(O)=C1O.CCOC(=O)C(=O)c1ccc(CC(C)C)cc1>>CC(C)Cc1ccc(C2(c3ccccc3)OC(=O)C(OCc3ccccc3)=C2O)cc1,,C1CCOC1,,,,val
US05789440,O=C(Cl)CCc1ccccc1.O=C1C=C(O)CC(CCc2ccccc2)(c2ccccc2)O1>>O=C1OC(CCc2ccccc2)(c2ccccc2)CC(O)=C1CCc1ccccc1,CN(C)c1ccncc1,Cc1ccccc1,,C1CCOC1,CCN(CC)CC,val
US20080293770A1,CC(C)(C)OC(=O)N1CCC(n2c(=O)[nH]c3cc(C(F)(F)F)c(Cl)cc32)CC1.Cl>>Cl.O=c1[nH]c2cc(C(F)(F)F)c(Cl)cc2n1C1CCNCC1,,ClCCl,,,,val
US20130053386A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.OCCn1nc(-c2cccc(Br)c2)cc1Oc1ccc(C(F)(F)F)cc1>>CC(C)(C)[Si](C)(C)OCCn1nc(-c2cccc(Br)c2)cc1Oc1ccc(C(F)(F)F)cc1,,ClCCl,,Cc1cccc(C)n1,,val
US20140088075A1,CN1CCN(Cc2cc([N+](=O)[O-])ccc2F)CC1>>CN1CCN(Cc2cc(N)ccc2F)CC1,[Fe],CCO,,[Cl-].[NH4+],,val
US20130023541A1,CC(C)OC(=O)c1cccnc1N1CCNCC1.O=Cc1cccc(CO)c1>>CC(C)OC(=O)c1cccnc1N1CCN(Cc2cccc(CO)c2)CC1,,C1CCOC1,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100099729A1,O=C(O)[C@@H]1C[C@@H]2CCC[C@@H]2N1C(=O)OCC1c2ccccc2-c2ccccc21.OCCCCCl>>O=C(OCCCCCl)[C@@H]1C[C@@H]2CCC[C@@H]2N1C(=O)OCC1c2ccccc2-c2ccccc21,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20130102776A1,COc1ccc2c(c1C#CCN1CCN(C(=O)OC(C)(C)C)CC1)OCC2=O.O=Cc1n[nH]c2ccccc12>>COc1ccc2c(c1C#CCN1CCN(C(=O)OC(C)(C)C)CC1)O/C(=C\c1n[nH]c3ccccc13)C2=O,,CO,,C1CCNCC1,,val
US20090082358A1,FC(F)(F)c1ccc(Br)cc1.O=Cc1ccncc1Br>>OC(c1ccc(C(F)(F)F)cc1)c1ccncc1Br,,C1CCOC1,,II,[Mg],val
US05436229,COC(=O)[C@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1.Oc1ccc2ccccc2c1>>COC(=O)[C@H]1C[C@H](Oc2ccc3ccccc3c2)CN1C(=O)OCc1ccccc1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090099207A1,CC(C)(C)c1cccc(C2(N[C@H]3CS(=O)(=O)C[C@@H](Cc4ccc(N)cc4)[C@@H]3O)CC2)c1.Cl.Clc1cc(Cl)ncn1>>CC(C)(C)c1cccc(C2(N[C@H]3CS(=O)(=O)C[C@@H](Cc4ccc(Nc5cc(Cl)ncn5)cc4)[C@@H]3O)CC2)c1.Cl.Cl,,CC(C)O,,,,val
US20050261350A1,CC(=O)Nc1cc2c(cc1[N+](=O)[O-])NC(=O)C2(C)C.Fc1ccc(CBr)cc1>>CC1(C)C(=O)N(Cc2ccc(F)cc2)c2cc([N+](=O)[O-])c(N)cc21,,Cl,,O=C([O-])[O-].[K+].[K+],,val
US20160060256A1,CC1(C)CC(O)(c2nccs2)CCC1C(=O)[O-]>>CC1(C)CC(O)(c2nccs2)CCC1C(=O)O,,CO,,Cl,[Na+].[OH-],val
US20100069395A1,O=C(O)c1cnc2ccnn2c1.O=S(Cl)Cl>>O=C(Cl)c1cnc2ccnn2c1,,O=S(Cl)Cl,,ClCCl,,val
US20110183985A1,CC(=O)c1cc(Cl)c(C)c(C#N)c1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(=O)c1cc(Cl)c(C)c(C#N)c1OS(=O)(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20040249096A1,Cc1cc[c-](C)c1.[Cl-].[Cl-].[Zr+3]C1C=Cc2ccccc21>>CC1=CC(C)([Zr+2]C2C=Cc3ccccc32)C=C1.[Cl-].[Cl-],,CCOCC,,[Cl-].[Li+],,val
US20100240656A1,C=C(C)c1ccc2c(c1)OCO2>>CC(C)c1ccc2c(c1)OCO2,[Pd],CCOC(C)=O,,,,val
US20050261294A1,CC(C)c1ccc(C(=O)CBr)cc1.NC(N)=S>>CC(C)c1ccc(-c2csc(N)n2)cc1,,CO,,,,val
US20130327251A1,BrP(Br)Br.CCCCCCCCCCCCCCCCCCOc1cc(CO)cc(OCCCCCCCCCCCCCCCCCC)c1OCCCCCCCCCCCCCCCCCC>>CCCCCCCCCCCCCCCCCCOc1cc(CBr)cc(OCCCCCCCCCCCCCCCCCC)c1OCCCCCCCCCCCCCCCCCC,,ClCCl,,,,val
US20090142297A1,CCCCC(=O)Cl.NCc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O>>CCCCC(=O)NCc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20140274930A1,CC(=O)OC[C@H]1O[C@H](Oc2ccc(Br)cc2C)[C@@H](F)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>Cc1cc(Br)ccc1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1F,,CO,,C[O-].[Na+],,val
US20150336986A1,COC(=O)CCCn1cc2c(c1-c1cccc(C#N)c1)c(=O)n(C)c(=O)n2C>>Cn1c(=O)c2c(-c3cccc(C#N)c3)n(CCCC(=O)O)cc2n(C)c1=O,,C1CCOC1,,O,[Li+].[OH-],val
US20140018345A1,CN(C)CC(=O)O.Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(N)nc2c1-c1cccc(C(F)(F)F)c1>>Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(NC(=O)CN(C)C)nc2c1-c1cccc(C(F)(F)F)c1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04824468,CC(C)CC(=O)Cl.CCC1CNC(c2cccc(Cl)c2)O1>>CCC1CN(C(=O)CC(C)C)C(c2cccc(Cl)c2)O1,,ClCCl,,c1ccncc1,,val
US20030166639A1,CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)cc1NC(=O)CC(=O)c1cccc(-c2ccccn2)c1>>O=C1CC(c2cccc(-c3ccccn3)c2)=Nc2ccc(C(F)(F)F)cc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110294776A1,C1CCNC1.Nc1ncnn2c(-c3cccc(CCl)c3)cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c12>>Nc1ncnn2c(-c3cccc(CN4CCCC4)c3)cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c12,,CN(C)C=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20060183694A1,CCC1CC1(C(=O)O)C(=O)OC(C)(C)C.C[Si](C)(C)CCO.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC[C@H]1C[C@@]1(NC(=O)OCC[Si](C)(C)C)C(=O)OC(C)(C)C,,c1ccccc1,,CCN(CC)CC,,val
US20060084651A1,CCn1c(-c2nc(Br)cnc2N)nc2cnccc21.OB(O)c1cccc(-c2ccccc2)c1>>CCn1c(-c2nc(-c3cccc(-c4ccccc4)c3)cnc2N)nc2cnccc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070213345A1,CCOC(=O)C(C)(C)C(=O)c1ccco1.CN1C(C)(C)CC(NC(=O)c2ccc(NN)cc2)CC1(C)C>>CN1C(C)(C)CC(NC(=O)c2ccc(N3N=C(c4ccco4)C(C)(C)C3=O)cc2)CC1(C)C,,CC(=O)O,,,,val
US20140323470A1,CC(C)(C)c1cc(NC(=O)OCC(Cl)(Cl)Cl)n(-c2cccc(CO)c2)n1.C[C@H]1CCC[C@@H](C)N1c1nnc2ccc(O[C@@H]3CC[C@H](N)c4ccccc43)cn12>>C[C@H]1CCC[C@@H](C)N1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(CO)c4)c4ccccc43)cn12,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20100261698A1,CC(C)(C)OC(=O)c1ccc(C(=O)n2c(-c3cccnc3)cc3cc(C#N)ccc32)cc1>>N#Cc1ccc2c(c1)cc(-c1cccnc1)n2C(=O)c1ccc(C(=O)O)cc1,,O=C(O)C(F)(F)F,,,,val
US20160060273A1,CC(C)C(=O)Cl.COC(=O)c1cc(N)n(-c2ccc(F)cc2)n1>>COC(=O)c1cc(NC(=O)C(C)C)n(-c2ccc(F)cc2)n1,,CCOC(C)=O,ClCCl,CCN(CC)CC,O,val
US20060252782A1,N=S(=O)(CCCCNc1nc(Cl)ncc1I)c1cccc([N+](=O)[O-])c1>>N=S(=O)(CCCCNc1nc(Cl)ncc1I)c1cccc(N)c1,,C1CCOC1,Cl,[Na+].[OH-],,val
US20080090773A1,CCOC(=O)C=CN(C)C.O=C(Cl)c1cc(F)ccc1F>>CCOC(=O)C(=CN(C)C)C(=O)c1cc(F)ccc1F,,Cc1ccccc1,,CCN(CC)CC,,val
US20040006082A1,CC(C)OC(=S)CC(=O)c1ccco1.CI>>CS/C(=C\C(=O)c1ccco1)OC(C)C,,CCOC(C)=O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20120142714A1,CCOC(C)=O.CCOc1ccc2cn(-c3ccc(OC[C@H](C)NC(=O)OC(C)(C)C)cc3F)nc2c1>>CCOc1ccc2cn(-c3ccc(OC[C@H](C)NC(C)=O)cc3F)nc2c1.O,,CCOC(C)=O,,Cl,,val
US20110183938A1,COC(=O)c1c(CBr)n(S(=O)(=O)c2ccccc2)c2ncc(Cl)cc12.Cc1ccc(S(=O)(=O)NCC#N)cc1>>COC(=O)c1c(CN(CC#N)S(=O)(=O)c2ccc(C)cc2)n(S(=O)(=O)c2ccccc2)c2ncc(Cl)cc12,,CN(C)C=O,,Cl,[H-].[Na+],val
US06008372,COC(=O)C(Cc1cccc2c1CCCC2)(Cc1cccc2c1CCCC2)C(=O)OC>>O=C(O)C(Cc1cccc2c1CCCC2)Cc1cccc2c1CCCC2,,CCCCO,O,[K+].[OH-],,val
US20150376130A1,CCC=O.CCOC(=O)c1ccc(C(F)(F)F)nc1N>>CCCNc1nc(C(F)(F)F)ccc1C(=O)OCC,,CO,ClCCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120214837A1,CCc1nc(O)cc2cc(OC)c(OC)cc12.COc1ccc2nc(NC(C)C)c(CCl)cc2c1.Cl.ClCCl>>CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NC(C)C)c2cc(OC)c(OC)cc12.Cl.Cl,,C1CCOC1,ClCCl,[Li+].[OH-],,val
US20090209522A1,COc1ccc(C)c(N)c1.O=S(=O)(O)O>>COc1ccc(C)c(O)c1,,O,O=S(=O)(O)O,O=N[O-].[Na+],,val
US20110319394A1,CCOC(=O)CNc1ncccc1[N+](=O)[O-]>>CCOC(=O)CNc1ncccc1N,[Pd],CCOC(C)=O,,,,val
US20130142757A1,CC(C)c1cc(N)n(C)n1.O=C1CCCCC1>>CC(C)c1nn(C)c(N)c1C1=CCCCC1,,CC(=O)O,,,,val
US20040180925A1,CC1CC(NC(=O)OC(C)(C)C)CCN1c1ccncn1>>CC1(N)CCN(c2ccncn2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150376208A1,C[C@@H]1CN(C(=O)OC(C)(C)C)c2c(sc3ccc4c(ccc[n+]4[O-])c23)C(=O)N1C(=O)OC(C)(C)C.O=C(Cl)C(=O)Cl>>C[C@@H]1CN(C(=O)OC(C)(C)C)c2c(sc3ccc4nc(Cl)ccc4c23)C(=O)N1C(=O)OC(C)(C)C,,CN(C)C=O,,,,val
US20160096839A1,C[C@@H]1C=CC[C@H](NC(=O)OC(C)(C)C)c2cccc(c2)-c2ncccc2NC1=O>>C[C@@H]1CCC[C@H](NC(=O)OC(C)(C)C)c2cccc(c2)-c2ncccc2NC1=O,O=[Pt]=O,CCO,,,,val
US20030181496A1,CC(=O)C=O.Nc1cccc([N+](=O)[O-])c1N>>Cc1cnc2c([N+](=O)[O-])cccc2n1,,CCO,,O,[K+].[OH-],val
US20050038035A1,CC(C)(C)OC(=O)Nc1nc(CCNc2ccc([N+](=O)[O-])cn2)cs1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)Nc1nc(CCN(C(=O)OC(C)(C)C)c2ccc([N+](=O)[O-])cn2)cs1,,C1CCOC1,,,,val
US04125724,O=C=Nc1ccccc1>>O=CNc1ccccc1,C1COCCO1,CCN(CC)CC,,[H][H],,val
US20050124816A1,NC(=S)SCCC(F)=C(F)F.O=CCCl>>FC(F)=C(F)CCSc1nccs1,,C1COCCO1,,Cl,,val
US20050070441A1,CC(C)(C)N=C=O.Cc1cc(Oc2ccc(C(F)(F)F)cc2[N+](=O)[O-])n[nH]1>>Cc1cc(Oc2ccc(C(F)(F)F)cc2[N+](=O)[O-])nn1C(=O)NC(C)(C)C,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US04207320,Cc1ccc2ccccc2n1.Fc1ccc2ncccc2c1.II>>Fc1ccc2c(ccc3n4c(ccc5ccccc54)c[n+]23)c1.[I-],,Clc1ccccc1,,,,val
US20050277640A1,CS(=O)(=O)Cl.NCc1cc(Oc2ccc(Nc3cc(-c4ccccc4)nc(N)n3)cc2)ccn1>>CS(=O)(=O)NCc1cc(Oc2ccc(Nc3cc(-c4ccccc4)nc(N)n3)cc2)ccn1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20130040930A1,CC(=O)Cl.Cc1ccc(N2CCN(C(=O)c3ccc(N4CCCS4(=O)=O)cc3N)CC2)c(C)c1>>CC(=O)Nc1cc(N2CCCS2(=O)=O)ccc1C(=O)N1CCN(c2ccc(C)cc2C)CC1,,ClCCl,,CCN(CC)CC,O,val
US05466823,CCOC(=O)C(F)(F)F.O=C1CCCc2ccccc21>>O=C1CC(C(=O)C(F)(F)F)Cc2ccccc21,,CCOCC,Cl,CO,C[O-].[Na+],val
US20080269219A1,Cc1ccccc1OCCCc1oc(Cl)nc1-c1ccc(Cl)cc1.c1ccc(-c2ncc[nH]2)cc1>>Cc1ccccc1OCCCc1oc(-n2ccnc2-c2ccccc2)nc1-c1ccc(Cl)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04670421,CCOC(=O)c1ccc(N)cc1.C[Si](C)(C)CCCBr>>CCOC(=O)c1ccc(NCCC[Si](C)(C)C)cc1,,CN(C)P(=O)(N(C)C)N(C)C,,,,val
US20130345216A1,Cc1cccc2cc([C@H](C)N)n(-c3ccccc3)c(=O)c12.N#Cc1c[nH]c2ncnc(Cl)c12>>Cc1cccc2cc([C@H](C)Nc3ncnc4[nH]cc(C#N)c34)n(-c3ccccc3)c(=O)c12,,CCCCO,,CCN(CC)CC,,val
US20160158207A1,C=Cc1cc2c(cc1-c1cnn(C)c1)CCCN2c1nn(C2CCOCC2)c2c1CN(C(=O)NC)CC2>>CCc1cc2c(cc1-c1cnn(C)c1)CCCN2c1nn(C2CCOCC2)c2c1CN(C(=O)NC)CC2,[Pd],CO,,,,val
US05644024,COc1cccc2c1C[C@@](NC(=O)c1ccccc1)(C(=O)N[C@@H](Cc1ccccc1)C(=O)NC1CCCCC1)CC2.O=S(=O)(O)C(F)(F)F>>N[C@@H](Cc1ccccc1)C(=O)NC1CCCCC1.O=S(=O)(O)C(F)(F)F,,CO,,N#N,,val
US04734419,CCOC(=O)Cn1c(=O)[nH]c(=O)c2cc(Cl)c(Cl)cc21.Fc1cc(Br)ccc1CBr>>CCOC(=O)Cn1c(=O)n(Cc2ccc(Br)cc2F)c(=O)c2cc(Cl)c(Cl)cc21,,CN(C)C=O,,O,[H-].[Na+],val
US20160130262A1,CC1(C)OB(c2ccc(O)cc2)OC1(C)C.COc1ccc(-c2onc(-c3ccccc3Cl)c2Br)cc1>>COc1ccc(-c2onc(-c3ccccc3Cl)c2-c2ccc(O)cc2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O,,val
US20120077799A1,Nc1ncccc1C1CCC(c2ccccc2)CC1.O=S(=O)(Cl)CCCl>>O=S1(=O)CCN2C=CC=C(C3CCC(c4ccccc4)CC3)C2=N1,,C1CCOC1,,[H-].[Na+],,val
US20090062358A1,CCCN(N)Cc1ccc(Cl)c(Cl)c1.CCOC(=O)C(C)(C)Oc1ccc(CCCC(=O)O)cc1.O=C(Cl)C(=O)Cl.c1ccncc1>>CCCNC(=O)N(Cc1ccc(Cl)c(Cl)c1)NC(=O)CCCc1ccc(OC(C)(C)C(=O)OCC)cc1,,CCOC(C)=O,CN(C)C=O,CS(=O)(=O)O,,val
US20050026976A1,CI.O=C1NCc2c(Br)ccc(O)c21>>COc1ccc(Br)c2c1C(=O)NC2,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070043068A1,CC(C)O.COc1ccccc1-c1cn(S(=O)(=O)c2ccc(C)cc2)c2ncc(-c3ccc(N=C=O)c(C(=O)N(C)C)c3)cc12>>COc1ccccc1-c1c[nH]c2ncc(-c3ccc(NC(=O)OC(C)C)c(C(=O)N(C)C)c3)cc12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080242655A1,CCOC(=O)c1c(Nc2ccc([Si](C)(C)C)cc2F)c2cnccc2n1C.ClI>>CCOC(=O)c1c(Nc2ccc(I)cc2F)c2cnccc2n1C,,ClCCl,,,,val
US20120225866A1,CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCI)ccc21.O=c1[nH]c2ccccc2c(Cl)c1-c1ccccc1>>CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCn3c(=O)c(-c4ccccc4)c(Cl)c4ccccc43)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US04399143,CC(=O)C(C)(C)CO.FC(F)(F)c1ccc(Cl)nc1>>CC(=O)C(C)(C)COc1ccc(C(F)(F)F)cn1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04882348,CCC=O.Cl.Cl.NCCSc1nccn1Cc1cc(F)cc(F)c1>>CCCNCCSc1nccn1Cc1cc(F)cc(F)c1.Cl.Cl,,CO,,[BH3-]C#N.[Na+],,val
US20080227791A1,CNC1CCN(Cc2ccc(F)c(F)c2)CC1.FC(F)(F)c1ccc(Cl)nn1>>CN(c1ccc(C(F)(F)F)nn1)C1CCN(Cc2ccc(F)c(F)c2)CC1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20070276025A1,CC(=O)Oc1c[nH]c2ccccc12.O=C1Nc2cc(Br)ccc2C1=O>>O=C1Nc2cc(Br)ccc2/C1=C1/Nc2ccccc2C1=O,,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US04429140,CCCCCCCCCCCCc1ccccc1S(=O)(=O)O.CCc1ccc(C=O)cc1.CN(C)C=O.O=[N+]([O-])c1ccccc1.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO>>CCc1ccc(C=C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=Cc2ccc(CC)cc2)cc1,,CN(C)C=O,,,,val
US04927958,COc1cc(/C=C/C(C)=O)cc(OC)c1OC.O=CC(=O)O>>COc1cc(/C=C/C(=O)/C=C/C(=O)O)cc(OC)c1OC,,CC(=O)O,O,,,val
US20160016948A1,CC(C)n1cc(I)c2cnc(Br)cc21.CCOC(=O)Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>CCOC(=O)Cn1cc(-c2cn(C(C)C)c3cc(Br)ncc23)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CC#N,O=C([O-])[O-].[Na+].[Na+],val
US20060025416A1,BrCc1ccc(-c2ccccc2)cc1.O=[N+]([O-])c1cccc(O)c1>>O=[N+]([O-])c1cccc(OCc2ccc(-c3ccccc3)cc2)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20020115853A1,C[C@H](N)C(=O)O.O=[N+]([O-])c1ccc(Br)cc1F>>C[C@H](Nc1cc(Br)ccc1[N+](=O)[O-])C(=O)O,,CCO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20120184542A1,COC(=O)CC(=O)Nc1cc(C(=O)NC(CCNC(=O)OC(C)(C)C)c2cccc(Cl)c2)c(F)cc1Cl.Nc1nc(N2CCOCC2)ncc1C=O>>CC(C)(C)OC(=O)NCCC(NC(=O)c1cc(NC(=O)c2cc3cnc(N4CCOCC4)nc3[nH]c2=O)c(Cl)cc1F)c1cccc(Cl)c1,,CO,,C1CCNCC1,,val
US20090318467A1,Cc1cc(-c2cccc(C(F)(F)F)c2)c(C#C[Si](C)(C)C)nc1C(=O)N1CCC(N2CCCC2)CC1>>C#Cc1nc(C(=O)N2CCC(N3CCCC3)CC2)c(C)cc1-c1cccc(C(F)(F)F)c1,,C1CCOC1,CCO,Cl,O=C([O-])[O-].[K+].[K+],val
US20130041007A1,CI.Cc1ccc(S(=O)(=O)n2c3c(c4c(Cl)c(Cl)ccc42)CCCC3=O)cc1>>Cc1ccc(S(=O)(=O)n2c3c(c4c(Cl)c(Cl)ccc42)CCC(C)C3=O)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05358949,Cc1cccc2cc(N)c(=O)[nH]c12.O=C(Cl)CCl>>Cc1cccc2cc(NC(=O)CCl)c(=O)[nH]c12,,CC(C)=O,ClCCl,CCN(CC)CC,,val
US20150299121A1,Cc1ccc(C(=O)Nc2cc(F)cc(CN3CCN[C@@H](C)C3)c2C)cn1.O=C(O)C(F)C1CC1>>Cc1ccc(C(=O)Nc2cc(F)cc(CN3CCN(C(=O)C(F)C4CC4)[C@@H](C)C3)c2C)cn1,,O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05677466,COC(=O)C[C@@H]1C[C@@H](CO)NC1=O.CS(=O)(=O)Cl>>COC(=O)C[C@@H]1C[C@@H](COS(C)(=O)=O)NC1=O,,ClCCl,,CCN(CC)CC,O,val
US20130034504A1,O=CCCCCCCCCBr.OCCO>>BrCCCCCCCCC1OCCO1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070049577A1,COC(=O)[C@@H](Cc1cc(C)c2[nH]ncc2c1)NC(=O)N1CCC(c2cc3ccccc3[nH]c2=O)CC1>>Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)O)cc2cn[nH]c12,,C1CCOC1,O,[Li+].[OH-],,val
US20100137313A1,COc1cc(C)cc(Nc2ncc(-c3cnc(OC)c(C(=O)NN)c3)c(-n3nc(C(F)(F)F)cc3C)n2)c1.O=C(n1ccnc1)n1ccnc1>>COc1cc(C)cc(Nc2ncc(-c3cnc(OC)c(-c4n[nH]c(=O)o4)c3)c(-n3nc(C(F)(F)F)cc3C)n2)c1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20050043325A1,CN(C)C=O.O=C(O)c1[nH]ncc1[N+](=O)[O-]>>NC(=O)c1[nH]ncc1[N+](=O)[O-],,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20080234262A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Clc1nc(N2CCOCC2)c2cn[nH]c2n1>>CC(C)(C)OC(=O)n1ncc2c(N3CCOCC3)nc(Cl)nc21,,C1CCOC1,CCN(CC)CC,,,val
US20100152168A1,CCOC(=O)n1c(=O)[nH]c2ccccc21.ClI>>CCOC(=O)n1c(=O)[nH]c2ccc(I)cc21,,CC(=O)O,,,,val
US04336379,CCc1noc(C)c1-c1[nH]c2ccccc2c1C(=O)C(=O)N(C)C>>CCc1noc(C)c1-c1[nH]c2ccccc2c1C(O)CN(C)C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110294809A1,CC(C)(C)OC(=O)N1C2C=C(OS(=O)(=O)C(F)(F)F)CC1CC2.CC1(C)OB(c2ccc(N3CCN(S(C)(=O)=O)CC3)cc2)OC1(C)C>>CC(C)(C)OC(=O)N1C2C=C(c3ccc(N4CCN(S(C)(=O)=O)CC4)cc3)CC1CC2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20090137804A1,CNc1cc(Nc2cccc(C(F)(F)F)c2)ncn1.O=C=Nc1c(Cl)cccc1Cl>>CN(C(=O)Nc1c(Cl)cccc1Cl)c1cc(Nc2cccc(C(F)(F)F)c2)ncn1,,C1COCCO1,,,,val
US20090099169A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12.Cl>>Cc1cc(C(=O)NC2CCNCC2)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12.Cl,,CCOCC,Cl,,,val
US20070244125A1,CC(C)Br.CN(C)C1CCN(C(=O)c2ccc3[nH]c(C(=O)N4CCC(F)(F)CC4)cc3c2)C1>>CC(C)n1c(C(=O)N2CCC(F)(F)CC2)cc2cc(C(=O)N3CCC(N(C)C)C3)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20120088741A1,CC(C)(C)OC(=O)N1CCC(Cc2ccc3c(c2)OC(F)(F)O3)C1.Cl>>Cl.FC1(F)Oc2ccc(CC3CCNC3)cc2O1,,ClCCl,,,,val
US06248755B1,O=C[C@H]1CN([C@H](CC2CCC2)C(=O)OCc2ccccc2)C[C@@H]1c1cccc(F)c1.c1ccc2c(c1)ncn2C1CCNCC1>>O=C(OCc1ccccc1)[C@@H](CC1CCC1)N1C[C@H](c2cccc(F)c2)[C@@H](CN2CCC(n3cnc4ccccc43)CC2)C1,,C1CCOC1,CN(C)C=O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05965591,CC(C)(C)OC(=O)NCCOc1noc2ccccc12.O=C=O>>CC(C)(C)OC(=O)NCCOc1noc2cccc(C(=O)O)c12,,C1CCOC1,,[Li]CCCC,,val
US20140005188A1,CN1CCN(C(=O)OC(C)(C)C)C[C@H]1CN.Clc1cc2nccnc2c(Cl)n1>>CN1CCN(C(=O)OC(C)(C)C)C[C@H]1CNc1nc(Cl)cc2nccnc12,,CN1CCCC1=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20100041698A1,COc1cccc(OC)c1CNCc1ccccc1[N+](=O)[O-]>>COc1cccc(OC)c1CNCc1ccccc1N,,CO,,NN,O,val
US05495046,CCCNCCC.ClCCCc1cc(Cl)ccc1OCCc1ccccc1>>CCCN(CCC)CCCc1cc(Cl)ccc1OCCc1ccccc1,,ClCCl,,,,val
US20040122028A1,CC(C)Cn1c(=O)n(C)c(=O)c2c(C(=O)O)c(Cc3ccccc3C(F)(F)F)sc21.O=C(Cl)C(=O)Cl>>CC(C)Cn1c(=O)n(C)c(=O)c2c(C(=O)CCl)c(Cc3ccccc3C(F)(F)F)sc21,CN(C)C=O,ClCCl,,,,val
US20020016328A1,CCC(CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(N)=O>>CCC(C=O)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(N)=O,,CS(C)=O,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20020137776A1,CC(C)(C)OC(=O)CBr.O=C1SC(Cc2ccc(O)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)COc1ccc(CC2SC(=O)N(C(c3ccccc3)(c3ccccc3)c3ccccc3)C2=O)cc1,,CC#N,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150099893A1,C=C(C)C(=O)OC(=O)C(=C)C.COc1cc(OC)c(C(C)CCO)c(OC)c1>>C=C(C)C(=O)OCCC(C)c1c(OC)cc(OC)cc1OC,,C1CCOC1,,CCN(CC)CC,O,val
US05807846,CC(C)c1cc(C(C)C)c(CN2C(=O)c3ccccc3C2=O)c(C(C)C)c1>>CC(C)c1cc(C(C)C)c(CN)c(C(C)C)c1,,CO,,NN,O,val
US20100267696A1,O=C(c1csc(C2CCOCC2)c1)N1CCCCCC1.O=C1CCC(=O)N1Cl>>O=C(c1cc(C2CCOCC2)sc1Cl)N1CCCCCC1,,CC(=O)O,O,,,val
US04495187,CCCc1nnc2c(Cl)nc3ccccc3n12.CCNCC>>CCCc1nnc2c(N(CC)CC)nc3ccccc3n12,,CN(C)C=O,,,,val
US20090023917A1,COc1ccc2c(Cc3ccc(OCCN4CCCCC4)cc3)c(OS(=O)(=O)C(F)(F)F)ccc2c1.OB(O)c1ccc(F)cc1F>>COc1ccc2c(Cc3ccc(OCCN4CCCCC4)cc3)c(-c3ccc(F)cc3F)ccc2c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,,[Cs+].[F-],,val
US20090209607A1,C1COCCO1.COC(=O)c1cc(-c2c(Br)cnn2C)c(C)s1>>C=Cc1cnn(C)c1-c1cc(C(=O)OC)sc1C,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,O,,O=C([O-])[O-].[K+].[K+],,val
US20160102105A1,Cc1cc(Cl)cnc1C(=O)O.O=C(Cl)C(=O)Cl>>Cc1cc(Cl)cnc1C(=O)Cl,,ClCCl,,CN(C)C=O,,val
US20090186879A1,NCCCCN.O=[N+]([O-])c1ccc(Cl)c(N=C(Cl)Cl)c1>>O=[N+]([O-])c1ccc(Cl)c(N=C2NCCCCN2)c1,,C1CCOC1,,,,val
US20080114019A1,CCOCc1nc2cnc3cc(Br)cnc3c2n1CCCO.O=C1c2ccccc2C(=O)N1O>>CCOCc1nc2cnc3cc(Br)cnc3c2n1CCCON1C(=O)c2ccccc2C1=O,,CCOC(C)=O,CN(C)C=O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05780437,Cc1cc(C)cc(-c2[nH]c3ccc(N)cc3c2CCN(CCCCc2cccnc2)Cc2ccccc2)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cc(C)cc(-c2[nH]c3ccc(N=C=O)cc3c2CCN(CCCCc2cccnc2)Cc2ccccc2)c1,,c1ccncc1,,,,val
US20140051676A1,COCCN(c1ccccc1)c1nc(N)nc(-c2noc(-c3ccc(CO)nc3)n2)n1.CS(=O)(=O)Cl>>COCCN(c1ccccc1)c1nc(N)nc(-c2noc(-c3ccc(COS(C)(=O)=O)nc3)n2)n1,,ClCCl,,CCN(CC)CC,,val
US20100063038A1,C1COCCN1.Nc1ncnn2c(CCCBr)cc(Br)c12>>Nc1ncnn2c(CCCN3CCOCC3)cc(Br)c12,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,[I-].[Na+],val
US20090137580A1,Cn1ccc2ncnc(OCc3cccc(N)c3)c21.O=C=Nc1ccccc1>>Cn1ccc2ncnc(OCc3cccc(NC(=O)Nc4ccccc4)c3)c21,,C1CCOC1,,CCN(CC)CC,,val
US20110245224A1,C[C@H]1CNC[C@@H](C)O1.O=Cc1cc2c(Cl)noc2c(F)c1F>>C[C@H]1CN(c2c(C=O)cc3c(Cl)noc3c2F)C[C@@H](C)O1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20030119869A1,N#Cc1ccc(NC2CCN(CCC(c3ccccc3)c3ccccc3)CC2)c([N+](=O)[O-])c1>>N#Cc1ccc(NC2CCN(CCC(c3ccccc3)c3ccccc3)CC2)c(N)c1,,CO,,Cl,,val
US20090286995A1,CCCCOB(CCCCCC#N)OCCCC.O=S(=O)(O)O>>NC(=O)CCCCCB(O)O,,O,,[K+].[OH-],,val
US20080227985A1,CCCOS(=O)(=O)c1ccc(C)cc1.Nc1nc2c(s1)C[C@H](N)CC2>>CCCN[C@@H]1CCc2nc(N)sc2C1.Cc1ccc(S(=O)(=O)O)cc1,,CN(C)C=O,,,,val
US04143039,CC1(C)S[C@@H]2C(N)C(=O)N2C1c1nnn[nH]1.[N-]=[N+]=NCc1ccsc1CC(=O)O>>CC1(C)S[C@@H]2C(NC(=O)Cc3sccc3CN=[N+]=[N-])C(=O)N2C1c1nnn[nH]1,,C1CCOC1,O,CCN=C=NCCCN(C)C,Cl,val
US05886008,CN1CCC[C@@H]1Cc1c[nH]c2ccc(N)cc12.O=[N+]([O-])c1cc(-c2ccccc2)ccc1Br>>CN1CCCC1Cc1c[nH]c2ccc(Nc3ccc(-c4ccccc4)cc3[N+](=O)[O-])cc12,,CN(C)C=O,,CCN(CC)CC,,val
US20150353535A1,C=C1CCC(C(=O)OCC)CC1.O=C(Cl)C(Cl)(Cl)Cl>>CCOC(=O)C1CCC2(CC1)CC(=O)C2(Cl)Cl,,CCOCC,,,,val
US20150218181A1,COC(=O)C(F)(F)Cl.COC1CN(C(=O)c2ccc([N+](=O)[O-])c(O)c2)C1>>COC1CN(C(=O)c2ccc([N+](=O)[O-])c(OC(F)F)c2)C1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20060052403A1,CO.O=C(Cl)c1cccc(CBr)c1>>COC(=O)c1cccc(CBr)c1,,CO,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20120178752A1,CC(C)(C)OC(=O)N1CCCC1c1cccc(C(=O)Nc2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)c1.Cl>>Cl.O=C(Nc1ccc2c(c1)CN(C(=O)OCc1ccccc1)CC2)c1cccc(C2CCCN2)c1,,ClCCl,,C1COCCO1,,val
US20120122905A1,CC(C)c1noc(C2CCN(c3ncnc(Oc4ccc(C5COC(C)(C)OC5)cc4)c3[N+](=O)[O-])CC2)n1>>CC(C)c1noc(C2CCN(c3ncnc(Oc4ccc(C(CO)CO)cc4)c3[N+](=O)[O-])CC2)n1,,CC(C)=O,,Cl,,val
US20140031360A1,CC(C)(C)OC(=O)NC1CCNCC1.COc1cc(Cl)nc(Cl)n1>>COc1cc(Cl)nc(N2CCC(NC(=O)OC(C)(C)C)CC2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020082265A1,CC(C)[N+](=O)[O-].CC1(C)CCC(C)(C)c2cc(CBr)c(Br)cc21>>CC1(C)CCC(C)(C)c2cc(C=O)c(Br)cc21,,CCO,,[Na],,val
US20090197884A1,O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C(=O)OCc2ccccc2)CC1OCc1ccccc1>>NC(=O)c1ccccc1,,ClCCl,,C[Si](C)(C)I,,val
US20080032998A1,C1=C(c2ccccc2)CCNC1.O=C(O)c1cc2ncc(Br)cn2n1>>O=C(c1cc2ncc(Br)cn2n1)N1CC=C(c2ccccc2)CC1,,CC#N,O,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20110230483A1,CC(O)(CN)C(F)(F)F.O=C(OCc1ccccc1)ON1C(=O)CCC1=O>>CC(O)(CNC(=O)OCc1ccccc1)C(F)(F)F,,ClCCl,O,Cl,,val
US20110288067A1,CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Oc3ccccc3)nc12>>CC(C)NC(=O)c1c[nH]c2ncc(Oc3ccccc3)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160214972A1,CC1(C)C(=O)N(c2cnc(C#N)c(C(F)(F)F)c2)C(=S)N1c1ccc(O)cc1.Cc1ccc(S(=O)(=O)OCCCCCOCCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)cc1>>Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCCOc2ccc(N3C(=S)N(c4cnc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2)C(C)(C)C)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160207939A1,CC(C)(C)OC(=O)N1CCCC[C@@H]1CN.Cl>>Cl.NC[C@H]1CCCCN1,,C1CCOC1,,,,val
US05753664,COc1ccc(C(=O)c2ccc(CBr)cc2)cc1.Cc1[nH]c2cnn(C)c(=O)c2c1C>>COc1ccc(C(=O)c2ccc(Cn3c(C)c(C)c4c(=O)n(C)ncc43)cc2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20080114022A1,BrP(Br)Br.CS(=O)(=O)c1ccc(CO)cc1F>>CS(=O)(=O)c1ccc(CBr)cc1F,,CCOCC,O,,,val
US04694076,CCCCCCCCCCCCCCOC[C@H](CO[C@H]1O[C@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)OCCCCCCCCCCCCCC>>CCCCCCCCCCCCCCOC[C@H](CO[C@H]1O[C@H](CO)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)OCCCCCCCCCCCCCC,,CC(=O)O,,,,val
US20150210682A1,CC(C)(C)[Si](C)(C)OCCCOCCN(Cc1ccccc1)Cc1ccccc1>>OCCCOCCN(Cc1ccccc1)Cc1ccccc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05144045,CC=C(O)CO.CCCCCCCCCCCCCCCCBr>>C=CC(O)COCCCCCCCCCCCCCCCC,,CN(C)C=O,,O,[H-].[Na+],val
US20080096861A1,CC(C)(C)OC(=O)N1CCC(CCl)CC1.CC(C)(C)OC(=O)N1CCOC(CO)C1>>CC(C)(C)OC(=O)N1CCOC(CCl)C1,,ClC(Cl)(Cl)Cl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160272651A1,CCOC(=O)CBr.CCc1cc(Br)cc(C)c1N1CCNC1=O>>CCOC(=O)CN1CCN(c2c(C)cc(Br)cc2CC)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20080153812A1,COC(=O)c1cnc(N2CCN3CCCC3C2)nc1.COc1cc(CCc2cc(N)[nH]n2)cc(OC)c1>>COc1cc(CCc2cc(NC(=O)c3cnc(N4CCN5CCCC5C4)nc3)[nH]n2)cc(OC)c1,,Cc1ccccc1,,C[Al](C)C,,val
US20080096848A1,Nc1ccccc1-n1cccn1.O=C(Cl)c1cccc2c1C(=O)c1ccccc1-2>>O=C(Nc1ccccc1-n1cccn1)c1cccc2c1C(=O)c1ccccc1-2,,C1CCOC1,,[H-].[Na+],,val
US20060189663A1,CCN1C(=O)C(Nc2ccc(OC)cc2)=C(c2ccccc2)C1=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCN1C(=O)C(c2ccccc2)=C(Nc2ccc(OC)cc2)C1=S,,Cc1ccccc1,,,,val
US20100137361A1,CN1CC(O)Cc2c(N)cccc21.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>CN1CC(O)Cc2c(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cccc21,,C1CCOC1,,,,val
US20120022119A1,BrP(Br)Br.CC(C)(C)SCc1cc(NC(=O)C(C)(C)C)ccc1CO>>CC(C)(C)SCc1cc(NC(=O)C(C)(C)C)ccc1CBr,,COCCOC,,,,val
US20020099202A1,NC(N)=O.OCC1OC(c2nc(Cl)c(O)nc2O)CC1O>>Nc1nc(N)c(C2CC(O)C(CO)O2)nc1Cl,,CC(=O)O,,O=N[O-].[Na+],,val
US04638005,COC(=O)CCc1c[n+](C)ccn1.[I-]>>C[n+]1ccnc(CCC(=O)O)c1.[I-],,Cl,,,,val
US20160257682A1,CC(C)I.CC1CCC(C)N1c1n[nH]c2cc(Cl)ncc12>>CC1CCC(C)N1c1nn(C(C)C)c2cc(Cl)ncc12,,CN(C)C=O,,[H-].[Na+],,val
US20050267095A1,CC(C)(C)OC(=O)N1CCN(CCCCl)CC1.N#CC1(c2ccc(OCCCN3CCCC3)cc2)CCOCC1>>CC(C)(C)OC(=O)N1CCN(CCCOc2ccc(C3(C#N)CCOCC3)cc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130059834A1,CC(C)N.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2cc(OC(F)F)ccc21>>CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4ccc(OC(F)F)cc34)nc12,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20120142705A1,O=C(Nc1cnccn1)C(CC1CCCC1)N1C(=O)Cc2ccc(Cl)cc21>>Cn1ccc(NC(=O)C(CC2CCCC2)N2C(=O)Cc3ccc(Cl)cc32)n1,,c1ccccc1,,O=S(Cl)Cl,,val
US20150376208A1,C=CC(=O)Cl.Nc1ccc2oc(-c3ccc4cc5n(c4c3)C3(CCC3)CNC5=O)nc2c1>>C=CC(=O)Nc1ccc2oc(-c3ccc4cc5n(c4c3)C3(CCC3)CNC5=O)nc2c1,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,,val
US04446133,CCN(CC)C(=O)Cl.COc1ccc(N2CCNCC2)cc1>>CCN(CC)C(=O)N1CCN(c2ccc(OC)cc2)CC1,,ClC(Cl)Cl,,,,val
US20050203112A1,COC(=O)C(Cc1ccc(Cl)cc1Cl)c1ccc(Cl)cc1>>OCC(Cc1ccc(Cl)cc1Cl)c1ccc(Cl)cc1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100130446A1,C=C[Mg]Br.CON(C)C(=O)C(C)(CC1CCOCC1)c1ccc(SC)cn1>>C=CC(=O)C(C)(CC1CCOCC1)c1ccc(SC)cn1,,C1CCOC1,,Cl,,val
US20100035875A1,CI.CS(=O)(=O)c1cccc(-c2cccc3nc(Nc4ccc(CO)cc4)nn23)c1>>COCc1ccc(Nc2nc3cccc(-c4cccc(S(C)(=O)=O)c4)n3n2)cc1,,CS(C)=O,,[K+].[OH-],,val
US20110046132A1,O=C(NC(=S)Nc1c(Br)cc(F)cc1Br)c1ccccc1>>NC(=S)Nc1c(Br)cc(F)cc1Br,,CO,,C[O-].[Na+],,val
US20040215009A1,CCN(CC)CC.CCO.OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O>>OC[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O,,CCO,,,,val
US20060041123A1,C=Cc1c(F)cnc2ccc(F)cc12.CC(C)(C)OC(=O)NC1CCNCC1>>CC(C)(C)OC(=O)NC1CCN(CCc2c(F)cnc3ccc(F)cc23)CC1,,CN(C)C=O,,,,val
US04369312,CC1=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(N)[C@H]2SC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC1=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(=O)[C@H]2SC1,,CCN(CC)CC,,Cl,,val
US20160024021A1,COC(=O)c1cc(CCc2cnc(Nc3ccc(N4CCN(CCO)CC4)cc3)nc2)cc(OC)c1>>COc1cc(CCc2cnc(Nc3ccc(N4CCN(CCO)CC4)cc3)nc2)cc(C(=O)O)c1,,CO,,[Na+].[OH-],,val
US20090291937A1,CC(C)(C)OC(=O)NCCCc1cc(Br)cc(C2(C#N)CC2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(C)(C)OC(=O)NCCCc1cc(B2OC(C)(C)C(C)(C)O2)cc(C2(C#N)CC2)c1,,C1COCCO1,CCOC(C)=O,ClCCl,CC(=O)[O-].[K+],val
US20120190677A1,CC1(C)CC(c2cccc(N3CCOCC3)c2)Nc2c(C(=O)O)cccc21.CS(N)(=O)=O>>CC1(C)CC(c2cccc(N3CCOCC3)c2)Nc2c(C(=O)NS(C)(=O)=O)cccc21,,CN(C)C=O,O,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20110224079A1,CCOC(=O)OC1=C(c2c(C)cc(C)cc2C)C(=O)N(OCOC)C12CCN(OC)CC2>>CCOC(=O)OC1=C(c2c(C)cc(C)cc2C)C(=O)N(O)C12CCN(OC)CC2,,ClCCl,,C[Si](C)(C)Br,,val
US20130331420A1,COc1cccc(N)c1-c1nnnn1Cc1ccccc1.O=S(=O)(Cl)c1ccccc1>>COc1cccc(NS(=O)(=O)c2ccccc2)c1-c1nnnn1Cc1ccccc1,,ClCCl,c1ccncc1,,,val
US20120071503A1,COC(=O)N(CCc1cccc(OC)c1)C1CCCC1>>COc1ccc2c(c1)CCN(C1CCCC1)C2=O,,O=P(Cl)(Cl)Cl,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20020006934A1,CC(=O)c1ccc(O)cc1C.ClCCCBr>>CC(=O)c1ccc(OCCCCl)cc1C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130116245A1,C[C@@H]1CNCCN1C(=O)OC(C)(C)C.O=[N+]([O-])c1ccc(Br)cn1>>C[C@@H]1CN(c2ccc([N+](=O)[O-])nc2)CCN1C(=O)OC(C)(C)C,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05326838,CC(C)O.Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1>>C=CC=C.C=Cc1ccccc1,,CC(C)O,,,,val
US20120309739A1,COC(=O)c1cn(C)c(=O)c2c(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)oc12>>Cn1cc(C(=O)O)c2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c1=O,,C1COCCO1,Cl,[Na+].[OH-],,val
US20040176308A1,CC(=O)OC[C@H]1O[C@H](Br)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.O=c1[nH][nH]c(C(F)(F)C(F)(F)F)c1Cc1ccccc1OCc1ccccc1>>CC(=O)OC[C@H]1O[C@@H](Oc2n[nH]c(C(F)(F)C(F)(F)F)c2Cc2ccccc2OCc2ccccc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060069145A1,CCN1C(=O)C(C)(C)c2cc([N+](=O)[O-])c(NC(C)=O)cc21>>CCN1C(=O)C(C)(C)c2cc([N+](=O)[O-])c(N)cc21,,CCO,,Cl,,val
US20140323470A1,CC(C)N(C(=O)Cl)C(C)C.NNc1ccc(F)cn1>>CC(C)N(C(=O)NNc1ccc(F)cn1)C(C)C,,ClCCl,,CCN(CC)CC,O,val
US04238494,CCCCC(=O)CN.CSC(=C[N+](=O)[O-])S(C)=O>>CCCCc1c[nH]c(SC)c1[N+](=O)[O-],,CO,,Cl,C[O-].[Na+],val
US20150284331A1,CC(C)(C)OC(=O)N1CCC(F)(C=O)CC1.COc1cc2c(cc1OC)C(=O)CC2>>COc1cc2c(cc1OC)C(=O)C(=CC1(F)CCN(C(=O)OC(C)(C)C)CC1)C2,,C1CCOC1,,[Na+].[OH-],,val
US20100286103A1,C=NCS(=O)(=O)c1ccc(C)cc1.Cc1sc(C=O)cc1Br>>Cc1sc(-c2cnco2)cc1Br,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20060189604A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C(N)=O)C[C@H]1O.O=C(O)c1ccc([N+](=O)[O-])cc1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C(N)=O)C[C@@H]1OC(=O)c1ccc([N+](=O)[O-])cc1,,C1CCOC1,CN(C)C=O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140080825A1,COc1ccc(C2(C(=O)O)CC2)cc1.Nc1nc(-c2ccccc2)cs1>>COc1ccc(C2(C(=O)Nc3nc(-c4ccccc4)cs3)CC2)cc1,,CC#N,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20160200725A1,COc1cc(OC)c(Cl)c(-c2cc3cnc(SC)nc3n(CCCN3CCN(C(=O)OC(C)(C)C)CC3)c2=O)c1.O=C(OO)c1cccc(Cl)c1>>COc1cc(OC)c(Cl)c(-c2cc3cnc(S(C)=O)nc3n(CCCN3CCN(C(=O)OC(C)(C)C)CC3)c2=O)c1,,ClCCl,,,,val
US04774266,CCCCCCBr.c1ccc(-c2nnn[nH]2)cc1>>CCCCCCn1nnnc1-c1ccccc1,,CCO,,C[O-].[Na+],,val
US04420418,C=C.Cc1ccccc1>>CCc1ccccc1C,,CC(=O)O,,,,val
US20050143381A1,FC(F)(F)c1ccc(CBr)cc1.O=c1[nH]nc2c(Cl)c(-c3ccc(Cl)cc3)cnn12>>O=c1n(Cc2ccc(C(F)(F)F)cc2)nc2c(Cl)c(-c3ccc(Cl)cc3)cnn12,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20110065691A1,BrBr.Oc1ccccc1OC1CCCC1>>Oc1ccc(Br)cc1OC1CCCC1,,ClCCl,,,,val
US04430346,CCC(=O)OC(=O)CC.Cl.N=C(N)NCCCC[C@H](O)CC(N)=O>>CCC(=O)O[C@@H](CCCCNC(=N)N)CC(N)=O.Cl,,c1ccncc1,,,,val
US20090298829A1,CC1(C)CCC(N(C(=O)C(C)(C)C)[C@H]2C[C@@H](CN)N(C(=O)OC(C)(C)C)C2)CC1.O=C(Cl)OCc1ccccc1>>CC1(C)CCC(N(C(=O)C(C)(C)C)[C@H]2C[C@@H](CNC(=O)OCc3ccccc3)N(C(=O)OC(C)(C)C)C2)CC1,,ClCCl,,,,val
US20080261920A1,CC/C(=C\[C@H](N)CO)c1ccccc1>>CCC(C[C@H](N)CO)c1ccccc1,[Pd],CO,,,,val
US20020065309A1,CN(C)c1ccc([C@@H]2C[C@@H]3CN(Cc4ccc(OCc5ccccc5)c(OCc5ccccc5)c4)CC34C(=O)N(CCN3CCOCC3)C(=O)N24)c2ccccc12>>CN(C)c1ccc([C@@H]2C[C@@H]3CN(Cc4ccc(O)c(O)c4)CC34C(=O)N(CCN3CCOCC3)C(=O)N24)c2ccccc12,,C1CCOC1,,,,val
US20130065914A1,CC(CCNC(=O)OC(C)(C)C)Oc1ncccc1[N+](=O)[O-]>>CC(CCNC(=O)OC(C)(C)C)Oc1ncccc1N,[Ni],CO,,,,val
US20150011533A1,CC(C)(C)OC(=O)N[C@@H]1CCCNC1.O=C(Nc1c[nH]c2ncc(Cl)c(F)c12)c1cnn(Cc2ccccc2)c1>>N[C@@H]1CCCN(c2c(Cl)cnc3[nH]cc(NC(=O)c4cnn(Cc5ccccc5)c4)c23)C1,,CCCCO,,,,val
US20140194418A1,COc1c(Nc2nc(Cc3c(Cl)cccc3Cl)c3ncn(COCC[Si](C)(C)C)c3c2C#N)ccc(N2CCN(C(=O)OC(C)(C)C)CC2)c1F>>COc1c(Nc2nc(Cc3c(Cl)cccc3Cl)c3nc[nH]c3c2C(N)=O)ccc(N2CCNCC2)c1F,O,O=S(=O)(O)O,,O=C([O-])O.[Na+],,val
US20130289275A1,COC(CNCc1ccccc1)OC.O=C(CCl)NCCc1ccccc1>>COC(CN(CC(=O)NCCc1ccccc1)Cc1ccccc1)OC,,O,,,,val
US20120142717A1,CN(Cc1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1)C(=N)N.COC(=O)/C(=C\O)Cc1cnc(OC)nc1>>COc1ncc(Cc2c[nH]c(N(C)Cc3ccc(Oc4ccc(Cl)c(C(F)(F)F)c4)cc3)nc2=O)cn1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20120065233A1,CC(C)I.O=C1NC(=O)c2cc([N+](=O)[O-])c(Cl)cc21>>CC(C)N1C(=O)c2cc(Cl)c([N+](=O)[O-])cc2C1=O,,CN(C)C=O,,O,[H-].[Na+],val
US20130274523A1,CCCCC/C=C\C/C=C\CCCCCCCCOC[C@H](O)CCCCCCCCC.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCCCC/C=C\C/C=C\CCCCCCCCOC[C@H](CCCCCCCCC)N=[N+]=[N-],,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140243336A1,CC(C)(C)OC(=O)NC1(C#N)CCS(=O)(=O)CC1>>CC(C)(C)OC(=O)NC1(CN)CCS(=O)(=O)CC1,[Ni],,,,,val
US04332745,CCOC(=O)CC(C)(C)C(C#N)C(=O)O.ClCl>>CCOC(=O)CC(C)(C)C(Cl)C#N,,O,,Cl,CC(=O)[O-].[Na+],val
US20110046132A1,Nc1cc(Cl)c(OC(F)(F)F)cc1[N+](=O)[O-]>>Nc1cc(Cl)c(OC(F)(F)F)cc1N,[Pt],CN(C)C=O,,,,val
US20070173506A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNc1n[nH]c2ccc(Br)cc12>>CC(C)(C)OC(=O)c1nn(C(=O)OC(C)(C)C)c2ccc(Br)cc12,CN(C)c1ccncc1,CC#N,,,,val
US20160031901A1,COc1ccc(Cn2c(=O)n3ncnc3c3c(C)csc32)cc1.O=C1CCC(=O)N1Br>>COc1ccc(Cn2c(=O)n3ncnc3c3c(C)c(Br)sc32)cc1,,CC#N,,,,val
US04808723,CCS(=O)(=O)c1ccc(Cl)c([N+](=O)[O-])c1.NC(N)=S>>CCS(=O)(=O)c1ccc2sc(N)nc2c1,,O=S1(=O)CCCC1,,O,,val
US20030162777A1,COC(=O)C1CCc2cc(Br)ccc2N1>>OCC1CCc2cc(Br)ccc2N1,,C1CCOC1,O,[BH4-].[Li+],,val
US20050277690A1,CN(C)c1ccc(CNC(=O)[C@H](N)Cc2ccccc2)cc1.O=C1CCC(=O)O1>>CN(C)c1ccc(CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CCC(=O)O)cc1,,C1CCOC1,CS(C)=O,,,val
US20070197636A1,Cc1cc2c(-c3cccc(/C=C/C(=O)O)c3)c(CC(=O)Nc3ccc(F)cc3C(F)(F)F)c(=O)oc2cc1Cl.OCCNCCO>>Cc1cc2c(-c3cccc(/C=C/C(=O)O)c3)c(CC(=O)Nc3ccc(F)cc3C(F)(F)F)c(=O)oc2cc1Cl.OCCNCCO,,C1CCOC1,CCO,,,val
US20160151362A1,CC(C)(C)OC(=O)N1CCN(C(=O)Cn2sc3cc(Br)ccc3c2=O)CC1>>O=C(Cn1sc2cc(Br)ccc2c1=O)N1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05830903,Clc1ccc2ccccc2n1.c1nc[nH]n1>>c1ccc2nc(-n3cncn3)ccc2c1,,CN(C)C=O,,[Na],,val
US20150197511A1,Nc1ccc(F)c(C2CC2)c1.O=C(Cl)Oc1ccccc1>>O=C(Nc1ccc(F)c(C2CC2)c1)Oc1ccccc1,,ClCCl,,O,c1ccncc1,val
US04824834,O=S(Cl)Cl.OCc1ccc(Sc2ccccc2)cc1>>ClCc1ccc(Sc2ccccc2)cc1,,ClCCl,,,,val
US07094798B1,COc1ccc2c(c1)c1c3c(c(-c4ccccc4Cl)cc1n2CCC(=O)NS(=O)(=O)CCN(C)C)C(=O)NC3=O>>CN(C)CCS(=O)(=O)NC(=O)CCn1c2ccc(O)cc2c2c3c(c(-c4ccccc4Cl)cc21)C(=O)NC3=O,,O=C([O-])O,[Na+],,,val
US06100258,C=C(C)COc1ccc(Br)cc1CN(CC)c1ccc(C(=O)NN)nn1.S=C(Cl)Cl>>C=C(C)COc1ccc(Br)cc1CN(CC)c1ccc(-c2n[nH]c(=S)o2)nn1,,C1CCOC1,,CCN(CC)CC,,val
US20100305067A1,O=C(Nc1nc2cc(Br)cnc2s1)c1ccccc1>>Nc1nc2cc(Br)cnc2s1,,O=S(=O)(O)O,,[Na+].[OH-],,val
US20070142438A1,Cc1ncoc1-c1nnc(SCCCCl)n1C.Fc1cc(C(F)(F)F)ccc1[C@@]12CNC[C@@H]1C2>>Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3F)C2)n1C.Cl,,CCOC(C)=O,CN(C)C=O,[I-].[K+],O=C([O-])O.[Na+],val
US20090105275A1,CCOC(=O)C(CC(C)C)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCCC(C(F)(F)F)N2Cc2ccc(C(F)(F)F)cc2)c1>>CC(C)CC(C(=O)O)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCCC(C(F)(F)F)N2Cc2ccc(C(F)(F)F)cc2)c1,,CCO,,[K+].[OH-],,val
US20020040014A1,C[Si](C)(C)CCO.O=C(O)c1sccc1Br>>C[Si](C)(C)CCOC(=O)c1sccc1Br,,CC(Cl)Cl,,CCN(CC)CC,O=S(Cl)Cl,val
US05763489,O=C1c2ccccc2C(=O)N1CC1CCc2c(O)cccc2C1>>NCC1CCc2c(O)cccc2C1,,CCO,,NN,O,val
US20100004280A1,C=CC(C)(Cc1cn(S(=O)(=O)N(C)C)c(C(C)(O)Cc2ccc(-c3ccc(F)cn3)cc2)n1)C(F)(F)F>>C=CC(C)(Cc1c[nH]c(C(C)(O)Cc2ccc(-c3ccc(F)cn3)cc2)n1)C(F)(F)F,,CO,,Cl,,val
US20120136023A1,C=CCBr.CC(=O)c1ccc(C)cc1O>>C=CCOc1cc(C)ccc1C(C)=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04657911,CN(Cc1ccccc1)C1CN2CCC1CC2>>CNC1CN2CCC1CC2,[Pd],CCO,,,,val
US20090247577A1,O=[N+]([O-])c1ccccc1S(=O)(=O)N(C[C@@H]1CN(Cc2ccccc2)C[C@H]1Cc1ccccc1Br)C1CC1>>O=[N+]([O-])c1ccccc1S(=O)(=O)N(C[C@@H]1CNC[C@H]1Cc1ccccc1Br)C1CC1,,ClCCCl,,,,val
US20150025207A1,Br[Mg]C1CC1.Clc1cccc2c1CC(Br)=C2>>Clc1cccc2c1CC(C1CC1)=C2,,C1CCOC1,,[Cl-].[NH4+],,val
US20130023494A1,FC1(F)CNC1.O=S(=O)(Cl)c1ccc(F)cc1>>O=S(=O)(c1ccc(F)cc1)N1CC(F)(F)C1,,ClCCl,,CCN(CC)CC,Cl,val
US20110152273A1,CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.COC(=O)c1c(C)nc(Cl)nc1-c1cnn(C)c1>>COC(=O)c1c(C)nc(N[C@@H]2CCCC[C@@H]2NC(=O)OC(C)(C)C)nc1-c1cnn(C)c1,,CC(=O)N(C)C,,CCN(CC)CC,,val
US20150119380A1,Nc1ccc(Cl)nn1.O=C(CBr)c1cc2ccc(F)cc2oc1=O>>Br.O=c1oc2cc(F)ccc2cc1-c1cn2nc(Cl)ccc2n1,,CCO,O,,,val
US20120165347A1,CC1=NC2(CC(C3CCOC(C)(C)C3)Oc3ccc(Br)cc32)NC1=S.N>>CC1=NC2(CC(C3CCOC(C)(C)C3)Oc3ccc(Br)cc32)N=C1N,,CN(C)C=O,,CO,,val
US20040138232A1,CCOC(=O)CCC(=O)N1C(=O)Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc21>>CCOC(=O)CCC(=O)N1C(=O)Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc21,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US20100029710A1,CCc1nc2c(C)cc(CC(C)=O)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnnn3C(c3ccccc3)(c3ccccc3)c3ccccc3)ccc21>>CCc1nc2c(C)cc(CC(C)=O)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21,,CO,,,,val
US20120040954A1,CC(C)N1CCNCC1.O=Cc1ccc(F)cc1>>CC(C)N1CCN(c2ccc(C=O)cc2)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20100093718A1,N#Cc1ccn2ccnc2c1.[N-]=[N+]=[N-].[NH4+]>>c1cn2ccc(-c3nn[nH]n3)cc2n1,,CCOCC,CN(C)C=O,[Cl-].[Na+],,val
US20120269738A1,CN(C)C=O.COCCOCCn1c2ccccc2c2cc(Br)ccc21>>COCCOCCn1c2ccccc2c2cc(C=O)ccc21,,C1CCOC1,,[Li]CCCC,,val
US20040110804A1,CO.CON(Cc1ccccc1F)C(=O)C=C1OC(C)(C)OC1=O>>COC(=O)C(O)=CC(=O)N(Cc1ccccc1F)OC,,CO,,,,val
US04845233,C=O.Cn1cc[nH]c1=O>>Cn1ccn(CO)c1=O,,CC(C)=O,,CO,[Na+].[OH-],val
US20050009845A1,C#Cc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2s1.Ic1ccccn1>>Fc1cccc(COc2ccc(Nc3ncnc4cc(C#Cc5ccccn5)sc34)cc2Cl)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,,C1CCOC1,CCN(CC)CC,val
US05037714,N#CC(C#N)=Cc1ccc(O)cc1.O=S(=O)(Cl)c1cc(Cl)c(Cl)cc1Cl>>N#CC(C#N)=Cc1ccc(OS(=O)(=O)c2cc(Cl)c(Cl)cc2Cl)cc1,,c1ccncc1,,,,val
US04565882,CCCc1c(OCCCCCOc2ccc3c(=O)cc(C(=O)OCC)oc3c2CCC)ccc(C(C)=O)c1O>>CCCc1c(OCCCCCOc2ccc3c(c2CCC)OC(C(=O)OCC)CC3O)ccc(C(C)=O)c1O,[Ni],C1CCOC1,,CCO,,val
US05624937,Brc1cccc2ccccc12.O=[N+]([O-])c1ccc(S)cc1>>O=[N+]([O-])c1ccc(Sc2cccc3ccccc23)cc1,[Cu],c1ccncc1,,O=C([O-])[O-].[K+].[K+],,val
US20080261921A1,CNC.COc1ccccc1-c1nn(CCOCC[Si](C)(C)C)c2ncc(-c3nc(CC(=O)O)ccc3O)cc12>>COc1ccccc1-c1n[nH]c2ncc(-c3cccc(C(O)C(=O)N(C)C)n3)cc12,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070087346A1,CC(=O)Nc1cc2c(cc1Br)C(=O)CC2.O=[N+]([O-])O>>CC(=O)Nc1c(Br)cc2c(c1[N+](=O)[O-])CCC2=O,,O,,,,val
US20140161736A1,O=C(N[C@@H](c1ccccc1)c1cccc(OCc2ccc(C(=O)OCc3cccc(C4OCCO4)c3)cc2)c1)O[C@H]1CN2CCC1CC2>>O=Cc1cccc(COC(=O)c2ccc(COc3cccc([C@@H](NC(=O)O[C@H]4CN5CCC4CC5)c4ccccc4)c3)cc2)c1,,C1CCOC1,CCOC(C)=O,Cl,,val
US20110306589A1,COC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)ccc(C)c1C>>Cc1ccc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c(C(=O)O)c1C,,c1ccncc1,,[I-].[Li+],,val
US04108872,C=CC#N.CN(C)c1cccc(O)c1>>CN(C)c1cccc(OCCC#N)c1,,CC(=O)O,,[Na],,val
US07495007B2,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1Nc2cc(Cl)ccc2/C1=C/c1cc(Cl)ccc1O>>CC(C)(C)OC(=O)Oc1ccc(Cl)cc1C=C1C(=O)N(C(=O)OC(C)(C)C)c2cc(Cl)ccc21,CN(C)c1ccncc1,ClCCl,,,,val
US06136823,CCOC(=O)c1cn(-c2cc(NC(=O)OC(C)(C)C)c(F)cc2F)c2c(C)c([N+](=O)[O-])c(OC)cc2c1=O>>CCOC(=O)c1cn(-c2cc(NC(=O)OC(C)(C)C)c(F)cc2F)c2c(C)c(N)c(OC)cc2c1=O,[Fe],CC(=O)O,,,,val
US20100152213A1,Fc1cccc(F)c1N=C=S.Nc1ccc(Br)cc1C(=O)O>>O=c1c2cc(Br)ccc2[nH]c(=S)n1-c1c(F)cccc1F,,CCO,,,,val
US20100120798A1,CC(C)(C)OC(=O)N1CCC(C#N)(C(=O)O)CC1.Cc1ccc(N)nc1>>Cc1ccc(NC(=O)C2(C#N)CCN(C(=O)OC(C)(C)C)CC2)nc1,,CC(=O)N(C)C,CCOC(C)=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US07863310B2,CC(C)(C)n1cc(C(=O)O)c(-c2ccc(F)cc2)n1.CCOC(C)=O>>CCOC(=O)c1cn(C(C)(C)C)nc1-c1ccc(F)cc1,,CCOC(C)=O,CN(C)C=O,O=C1CCC(=O)N1Br,,val
US06921763B2,COc1cc(-c2nn(C3CCN(C4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1N.O=C(Cl)CCc1ccccc1>>COc1cc(-c2nn(C3CCN(C4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)CCc1ccccc1,,c1ccncc1,,,,val
US20070032531A1,CN(C)c1ccc(CN)cc1.O=C(O)c1nc(-c2ccc(Cl)cc2)cs1>>CN(C)c1ccc(CNC(=O)c2nc(-c3ccc(Cl)cc3)cs2)cc1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20140275085A1,COc1nc(NC2CC2)ncc1-c1ccc(Oc2ccnc(-c3cnn(C)c3)c2)c(C)n1>>Cc1nc(-c2cnc(NC3CC3)[nH]c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1,,CC(=O)O,,Br,,val
US20160016948A1,CC(C)n1cnc2cnc(Nc3ccnc(Cl)n3)cc21.O=C1NCC2(CCNCC2)O1>>CC(C)n1cnc2cnc(Nc3ccnc(N4CCC5(CC4)CNC(=O)O5)n3)cc21,,CC(C)O,O,CCN(CC)CC,,val
US20120149718A1,BrCc1ccccc1.CS(=O)(=O)c1ccc(CC(=O)Nc2nc3ccccc3o2)cc1>>CS(=O)(=O)c1ccc(C(Cc2ccccc2)C(=O)Nc2nc3ccccc3o2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20120134959A1,C1CC2COCC1N2.Clc1cc(Cl)nc(Cl)n1>>Clc1cc(N2C3CCC2COC3)nc(Cl)n1,,CCO,,CCN(CC)CC,Cl,val
US06071903,COC(=O)C1CN(C(=O)c2cc(F)ccc2C)c2ccccc2CN1S(=O)(=O)c1ccc(OC)cc1>>COc1ccc(S(=O)(=O)N2Cc3ccccc3N(C(=O)c3cc(F)ccc3C)CC2C(=O)O)cc1,,C1CCOC1,,[Na+].[OH-],,val
US20100158818A1,CCCCCCCCCCCCN(C)CCC(C)(C)N.O=C(OCc1ccccc1)ON1C(=O)CCC1=O>>CCCCCCCCCCCCN(C)CCC(C)(C)NC(=O)OCc1ccccc1,,C1CCOC1,,,,val
US20110046133A1,CCOP(=O)(CCc1cc(C)c(-c2nc3ccc(C(=O)Nc4ccc5ccccc5n4)cc3[nH]2)c(C)c1)OCC>>Cc1cc(CCP(=O)(O)O)cc(C)c1-c1nc2ccc(C(=O)Nc3ccc4ccccc4n3)cc2[nH]1,,ClCCl,,C[Si](C)(C)Br,,val
US20110263648A1,COc1cccc(NC(=O)CCCN(C)C(=O)OCc2ccccc2)c1N>>COc1cccc2[nH]c(CCCN(C)C(=O)OCc3ccccc3)nc12,CN(C)C=O,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US06562823B1,C1CNCCN1.ClCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>c1ccc(C(c2ccccc2)(c2ccccc2)n2cnc(CCN3CCNCC3)c2)cc1,,CCO,,,,val
US09060515B2,CCOC(=O)c1cnc(Cl)cc1Cl.Cc1cccc(N)c1>>CCOC(=O)c1cnc(Cl)cc1Nc1cccc(C)c1,Cl,CCO,,,,val
US20120094972A1,Cc1c(-c2ccccn2)nc2cccc(F)c2c1Cl.Clc1cnc2c(c1)NCCS2>>Cc1c(-c2ccccn2)nc2cccc(F)c2c1N1CCSc2ncc(Cl)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20020183259A1,CC(C)(C)[Si](C)(C)Cl.Cc1cc(CO)cc(C)c1O>>Cc1cc(CO[Si](C)(C)C(C)(C)C)cc(C)c1O,,ClCCl,,CCN(CC)CC,,val
US20070099990A1,Cc1ccc(C(=O)COc2cc(C)cc(C)c2C)cc1>>Cc1ccc(-c2coc3c(C)c(C)cc(C)c23)cc1,,O,,,,val
US20120225844A1,C[Si](C)(C)Cl.O=C1N[C@H](CO)Cn2nc(COc3ccccc3)cc21>>C[Si](C)(C)OC[C@@H]1Cn2nc(COc3ccccc3)cc2C(=O)N1,,CC#N,,Cl,,val
US20090048306A1,BrC1CCOC1.Oc1ccc(F)cc1Br>>Fc1ccc(OC2CCOC2)c(Br)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080318947A1,CCn1c(-c2nonc2N)nc2c(Cl)nc(OCCNC(=O)OC(C)(C)C)cc21.OB(O)c1ccoc1>>CCn1c(-c2nonc2N)nc2c(-c3ccoc3)nc(OCCNC(=O)OC(C)(C)C)cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20100331306A1,CC(c1nc2ccc(F)cc2cc1-c1cncc(F)c1)n1nc(I)c2c(N)ncnc21.CC1(C)OB(c2cscn2)OC1(C)C>>CC(c1nc2ccc(F)cc2cc1-c1cncc(F)c1)n1nc(-c2cscn2)c2c(N)ncnc21,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,CCOCC,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],,val
US06028033,CC1C=C(c2cccc(C(F)(F)F)c2)OC(=O)C1.CCOC(=O)NN>>CCOC(=O)NN1C(=O)CC(C)C=C1c1cccc(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,,val
US20120252777A1,COC(=O)c1ccc(CCc2cccc(B3OC(C)(C)C(C)(C)O3)c2)cc1.COc1ccc(Nc2nc(Cl)nc3scnc23)cc1OC>>COC(=O)c1ccc(CCc2cccc(-c3nc(Nc4ccc(OC)c(OC)c4)c4ncsc4n3)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20050143381A1,O=c1c(-c2ccncc2)c(-c2ccc(F)cc2)cnn1Cc1ccccc1>>O=c1[nH]ncc(-c2ccc(F)cc2)c1-c1ccncc1,,Cc1ccccc1,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20110118245A1,CC(C)(C)C(=O)CC#N.Cl.NNC1CCCCC1>>CC(C)(C)c1cc(N)n(C2CCCCC2)n1.Cl,,CCO,,,,val
US20050043309A1,COC1=CCc2cccc(N3CCN(CCCCOc4ccc5ccc(=O)[nH]c5n4)CC3)c2C1>>O=C1CCc2cccc(N3CCN(CCCCOc4ccc5ccc(=O)[nH]c5n4)CC3)c2C1,,C1CCOC1,CCO,Cl,,val
US20070105890A1,CCOC(=O)c1c(F)cc2c3nc(N4CCC[C@@H](N)C4)n(Cc4ccccc4Cl)c3c(=O)n(C)c2c1F.Cl>>Cl.Cn1c(=O)c2c(nc(N3CCC[C@@H](N)C3)n2Cc2ccccc2Cl)c2cc(F)c(C(=O)O)c(F)c21,,Cl,,,,val
US20040209905A1,CCCN.COc1cc2ncnc(Oc3ccc(N)c([N+](=O)[O-])c3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCNC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1[N+](=O)[O-],,CCN(CC)CC,ClC(Cl)Cl,CO,,val
US20070161680A1,CNc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1N.FC(F)(F)c1ccc(N=C=S)cc1>>Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21,,CC#N,O,CCN(CC)CC,C[n+]1ccccc1Cl.[I-],val
US20040077877A1,Fc1ccc(-c2n[nH]c3ccc(/C=C/c4ccccn4)cc23)cc1>>Fc1ccc(-c2n[nH]c3ccc(CCc4ccccn4)cc23)cc1,,CO,,,,val
US05175291,CCCBr.Nc1cc(=O)[nH]c(=O)n1Cc1ccccc1>>CCCn1c(=O)cc(N)n(Cc2ccccc2)c1=O,,CCO,,[Na+].[OH-],,val
US20080221136A1,CC(C)(C)[Si](C)(C)Cl.COC(=O)C(O)c1ccc(OC)cc1>>COC(=O)C(O[Si](C)(C)C(C)(C)C)c1ccc(OC)cc1,,CN(C)C=O,,O,c1c[nH]cn1,val
US20100331320A1,C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2F)OC1=O.Cn1cc(Br)ccc1=O>>C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2F)OC1=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05405865,C#CCc1cc(COC2CCCCO2)c(C(F)(F)F)o1>>C#CCc1cc(CO)c(C(F)(F)F)o1,,CO,,Cc1ccccc1S(=O)(=O)O,,val
US20060116515A1,CCOC(=O)C(=O)CBr.Cc1cc(C2C(C(N)=S)CCN2C(=O)OC(C)(C)C)nc(-n2ccnc2)n1>>CCOC(=O)c1csc(C2CCN(C(=O)OC(C)(C)C)C2c2cc(C)nc(-n3ccnc3)n2)n1,,ClCCl,,O=C([O-])O.[Na+],,val
US05559230,NCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1.O=C(Cl)c1ccccc1>>O=C(NCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US04968829,CC(C)=CCOc1ccc(O)cc1.CC(Cl)C#N>>CC(C)=CCOc1ccc(OC(C)C#N)cc1,,CN(C)C=O,,[H-].[Na+],,val
US04213993,CCCC(=O)c1cc2nc(C(=O)[O-])n(C)c2cc1C.CCOC(=O)OC(=O)OCC>>CCCC(=O)c1cc2nc(C(=O)OCC)n(C)c2cc1C,,CCOC(C)=O,,CC#N,CCN(CC)CC,val
US05216165,CCN(CC)C(=O)c1ccc(CN2CCC(N)CC2)cc1.Cl.O=Cc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1>>CCN(CC)C(=O)c1ccc(CN2CCC(NCc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)CC2)cc1.Cl,,Cc1ccccc1,,O,[BH4-].[Na+],val
US20090318410A1,CC(=O)Cc1ccc(S(C)(=O)=O)cc1.O=S(=O)(Cl)Cl>>CC(=O)C(Cl)c1ccc(S(C)(=O)=O)cc1,,ClCCl,,,,val
US20060205715A1,CC(C)(C)OC(=O)NCC1CCc2cc(O)ccc21.NC(=O)c1ccc(Cl)nc1>>CC(C)(C)OC(=O)NCC1CCc2cc(Oc3ccc(C(N)=O)cn3)ccc21,,CS(C)=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20090325952A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(NC(=O)CCCCCCCBr)c1.CNCCO>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(NC(=O)CCCCCCCN(C)CCO)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US03962227,BrP(Br)Br.O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=CC(O)S[C@H]12>>O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(Br)CS[C@H]12,,CN(C)C=O,,CCOC(C)=O,O,val
US20140206875A1,CI.COC(=O)C(C)(C)NS(=O)(=O)c1cccc2cccnc12>>COC(=O)C(C)(C)N(C)S(=O)(=O)c1cccc2cccnc12,,CN(C)C=O,,O,,val
US20050222213A1,CCC(=O)Cl.OCC(Oc1ccc(C(F)(F)F)cc1)c1cccc(C(F)(F)F)c1>>CCC(=O)OCC(Oc1ccc(C(F)(F)F)cc1)c1cccc(C(F)(F)F)c1,,c1ccncc1,,CCOCC,O,val
US20120129840A1,CC1(C)OB(c2ccc3c4c(cccc24)CC3)OC1(C)C.CCCC(C(=O)OC)c1c(C)nc(N2CCCCC2)nc1Cl>>CCCC(C(=O)OC)c1c(C)nc(N2CCCCC2)nc1-c1ccc2c3c(cccc13)CC2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,CCN(C(C)C)C(C)C,,val
US20020183371A1,COC(OC)c1ccc(N2C[C@H](CNC(C)=O)OC2=O)cc1F>>CC(=O)NC[C@H]1CN(c2ccc(C=O)c(F)c2)C(=O)O1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20130303492A1,CC(=O)c1ccc(N)cc1.CSC(SC)=C(C#N)C(N)=O.NN>>CC(=O)c1ccc(Nc2n[nH]c(N)c2C(N)=O)cc1,,CCO,,O,,val
US20140275175A1,CN1C(=O)Cc2c1ccc(B1OC(C)(C)C(C)(C)O1)c2Cl.OCc1c(Cl)cncc1Br>>CN1C(=O)Cc2c1ccc(-c1cc(Cl)cnc1CO)c2Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US05576343,CCOC(=O)Cc1ccc(OC)cc1.CCOC(=O)OCC>>CCOC(=O)C(C(=O)OCC)c1ccc(OC)cc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20130059834A1,CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3n[nH]c4ccc(OC(F)F)cc34)nc12.CNC(=O)CCl>>CNC(=O)Cn1nc(-c2cnc3c(n2)c(C(=O)NC(C)(C)C)cn3COCC[Si](C)(C)C)c2cc(OC(F)F)ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020165245A1,Cc1ccc(S(=O)(=O)OC[C@H]2COc3cc(F)ccc3O2)cc1.O=[N+]([O-])O>>Cc1ccc(S(=O)(=O)OCC2COc3cc(F)c([N+](=O)[O-])cc3O2)cc1,,ClCCCl,,,,val
US20120149737A1,COC(=O)c1ccc(N=C=O)cc1.COc1cc(I)cc(OC(C)C)c1Cl>>COC(=O)c1ccc(NC(=O)c2cc(OC)c(Cl)c(OC(C)C)c2)cc1,,C1CCOC1,,[Li]CCCC,,val
US06319924B1,Clc1nn2c(-c3ccccc3)nnc2cc1N1CC=CCC1.Cn1ncnc1CO>>Cn1ncnc1COc1nn2c(-c3ccccc3)nnc2cc1N1CC=CCC1,,CN(C)C=O,,O,[H-].[Na+],val
US20060211709A1,COC(=O)C1C(N)=NC=C(c2cccc(CO)c2)N1C.O=S(Cl)Cl>>COC(=O)C1C(N)=NC=C(c2cccc(CCl)c2)N1C,,C1CCOC1,,c1ccncc1,,val
US04122183,CCCCN(C(=O)C(C)C)c1nc(C)co1.O=C(OO)c1cccc(Cl)c1>>CCCCN(C(=O)C(C)C)c1nc(C)c(O)o1,,ClCCl,,,,val
US20030153570A1,CI.COC(=O)c1cc(Cl)ccc1N>>CNc1ccc(Cl)cc1C(=O)OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130196974A1,O=S1(=O)CCN(c2cc(Cl)c3cc(O)ccc3n2)Cc2ccccc21.OCCBr>>O=S1(=O)CCN(c2cc(Cl)c3cc(OCCO)ccc3n2)Cc2ccccc21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05162322,CCC(Cl)CC1CN(C)C(=O)O1.CCOc1ccccc1N1CCNCC1.Cl>>CCOc1ccccc1N1CCN(CCCCC2CN(C)C(=O)O2)CC1.Cl.Cl,,CCCCO,,[I-].[K+],,val
US20070117985A1,C[C@H](NC1=NC(=O)C(C)(c2ccc(C#N)cc2)S1)c1ccccc1C(F)(F)F.[OH-]>>C[C@H](NC1=NC(=O)C(C)(c2ccc(C(N)=O)cc2)S1)c1ccccc1C(F)(F)F,,CC(C)(C)O,,Cl,,val
US20120208788A1,CCOC(=O)c1c(OCc2ccccc2)ccc(C#N)c1C>>Cc1c(C#N)ccc(OCc2ccccc2)c1C(=O)O,,C1CCOC1,CO,[Na+].[OH-],,val
US04342771,CO.O=C(O)c1cccnc1Cl>>COc1ncccc1C(=O)O,,CO,,C[O-].[Na+],,val
US20120077799A1,O=S1(=O)CCN2C=CC=C(Br)C2=N1.OB(O)c1ccc(Oc2ccccc2)cc1>>O=S1(=O)CCN2C=CC=C(c3ccc(Oc4ccccc4)cc3)C2=N1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100197679A1,Brc1ccc2c(c1)CCC(NCc1cc3c(cn1)OCCO3)C2.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCc2cc(Br)ccc2C1,,CO,,O=C([O-])O.[Na+],,val
US20100273776A1,CC#N.CCOC(=O)c1ccc(C)cc1>>Cc1ccc(C(=O)CC#N)cc1,,Cc1ccccc1,,[H-].[Na+],,val
US20100216810A1,CC(=O)Nc1nc2ccc(Oc3cccc(N)c3)c(C#N)c2s1.CC(C)(C#N)c1cc(C(=O)O)ccc1Cl>>CC(=O)Nc1nc2ccc(Oc3cccc(NC(=O)c4ccc(Cl)c(C(C)(C)C#N)c4)c3)c(C#N)c2s1,,C1CCOC1,CCOC(C)=O,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20060040918A1,Clc1cnc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cn1.O=C1CCCN1>>O=C1CCCN1c1cnc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cn1,[Cu]I,C1COCCO1,CO,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US20040142286A1,FC(F)(Cl)COC(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>FC(F)=COC(F)(F)C(F)(F)C(F)(F)C(F)(F)F,,CS(C)=O,,[K+].[OH-],,val
US20010021718A1,NO.O=C(O)C[C@@H](CCCC1CCCCC1)c1nc(CS(=O)(=O)c2ccccc2)no1.O=C(n1ccnc1)n1ccnc1>>N.O=C(C[C@@H](CCCC1CCCCC1)c1nc(CS(=O)(=O)c2ccccc2)no1)NO,,C1CCOC1,,Cl,,val
US04379167,CCC(O)C(Cl)Oc1ccccc1Cl.c1ccc(N2CCNCC2)cc1>>OC(CCN1CCN(c2ccccc2)CC1)COc1ccccc1Cl,,CC(C)O,,Cl,[Na+].[OH-],val
US20120135999A1,Cc1cc2c(ccn2C2CCC2)cn1.O=C=NS(=O)(=O)Cl>>Cc1cc2c(cn1)c(C#N)cn2C1CCC1,,CN(C)C=O,,CC#N,O=C([O-])[O-].[Na+].[Na+],val
US20100168418A1,CNC(=O)c1cc(=O)n(CCN2CCC(NCc3ccc(C)c(F)c3)CC2)c2cc(OC)ccc12.Cl>>CNC(=O)c1cc(=O)n(CCN2CCC(NCc3ccc(C)c(F)c3)CC2)c2cc(OC)ccc12.Cl,,CO,,CCOC(C)=O,,val
US20100130496A1,CS(=O)(=O)c1nc(-c2cc(F)cc3[nH]ccc23)cc(N2CCOCC2)n1.NCCc1cccnc1>>Fc1cc(-c2cc(N3CCOCC3)nc(NCCc3cccnc3)n2)c2cc[nH]c2c1,,C1COCCO1,,,,val
US20130143859A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CC(N)=S>>CC(=S)NC(=O)C1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100240638A1,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@]2(CN1C(=O)OC(C)(C)C)CC2(C)C)C(=O)NS(=O)(=O)c1ccccc1NCCCCCCC[C@H](NC(=O)OC1CCCC1)C(=O)O>>C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@]2(CN1)CC2(C)C)C(=O)NS(=O)(=O)c1ccccc1NCCCCCCC[C@H](NC(=O)OC1CCCC1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070021482A1,CNC.FC(F)(F)c1cc(-c2cccc(CCl)c2)c2c(c1)ncn2-c1ccccc1>>CN(C)Cc1cccc(-c2cc(C(F)(F)F)cc3ncn(-c4ccccc4)c23)c1,,CN1CCCC1=O,,,,val
US20040181064A1,CC(C)(C)[Si](C)(C)Cl.COC(=O)[C@@H]1[C@H](O)CCCN1C(=O)OC(C)(C)C>>COC(=O)[C@@H]1[C@H](O[Si](C)(C)C(C)(C)C)CCCN1C(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US05945382,CC(C)(C)OC(=O)CCl.Clc1cc(Cl)cc(-c2n[nH]cc2Cl)c1>>CC(C)(C)OC(=O)Cn1cc(Cl)c(-c2cc(Cl)cc(Cl)c2)n1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20020132842A1,NN.O=[N+]([O-])c1c(F)cccc1F>>NNc1cccc(F)c1[N+](=O)[O-],,C1CCOC1,,O,,val
US04338326,Cc1cccc(Oc2ccccc2)n1.O=C(OO)c1cccc(Cl)c1>>Cc1cccc(Oc2ccccc2)[n+]1[O-],,ClCCl,,,,val
US20090215778A1,COc1ccc(-c2nc3c(C(=O)O)cnn3c(C(F)(F)F)c2C)cc1.C[C@@H]1CN([C@@H](C)c2cc(F)cc(F)c2)CCN1>>COc1ccc(-c2nc3c(C(=O)N4CCN([C@@H](C)c5cc(F)cc(F)c5)C[C@H]4C)cnn3c(C(F)(F)F)c2C)cc1,,CC#N,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070185153A1,CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCNCC1.Cc1ccc(S(=O)(=O)OCC2(O)Cn3c(=O)ccc4ncc(F)c2c43)cc1>>CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCN(CC2(O)Cn3c(=O)ccc4ncc(F)c2c43)CC1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20110183989A1,Nc1ccnn1-c1ccccc1.O=C(Cl)Oc1ccccc1>>O=C(Nc1ccnn1-c1ccccc1)Oc1ccccc1,,ClCCCl,ClCCl,,,val
US20120270866A1,CCn1c(=O)c(-c2ccc(C(=O)OC)cc2Cl)cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc21.NN>>CCn1c(=O)c(-c2ccc(C(=O)NN)cc2Cl)cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc21,,CCO,,O,,val
US05001125,CS(=O)(=O)c1ccc(Cl)nn1.Cc1cccc(N2CCNCC2)c1>>Cc1cccc(N2CCN(c3ccc(S(C)(=O)=O)nn3)CC2)c1,,c1ccccc1,,CCN(CC)CC,,val
US20060113247A1,OCCCl.SCCOCCS>>OCCSCCOCCS,,CCO,,[Na+].[OH-],,val
US20100029722A1,C#CCCCc1ccccc1.CCOC(=O)c1sc(N=[N+]=[N-])nc1C>>CCOC(=O)c1sc(-n2cc(CCCc3ccccc3)nn2)nc1C,[Cu]I,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20060183921A1,CCOC(=O)c1c(C2(c3cccc(Cl)c3)SCCCS2)csc1N.O=C1OC(=O)c2ccccc21>>CCOC(=O)c1c(C2(c3cccc(Cl)c3)SCCCS2)csc1N1C(=O)c2ccccc2C1=O,,CC(=O)O,,,,val
US20070112005A1,CCN(C(C)C)C(C)C.CO.Nc1nccn2c(C3CCC3)nc(I)c12.O>>COC(=O)c1nc(C2CCC2)n2ccnc(N)c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20150126449A1,Cc1ccc(Cl)c(C#N)c1F.NN>>Cc1ccc(Cl)c2c(N)n[nH]c12,,CCO,,O,,val
US20130040930A1,Cc1cc(C)c(N2CCN(C(=O)c3ccc(N4CCNC4=O)cc3C#N)CC2)nc1C.O=S(=O)(O)O>>Cc1cc(C)c(N2CCN(C(=O)c3ccc(N4CCNC4=O)cc3C(N)=O)CC2)nc1C,,O,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20130231367A1,COCc1cc2c(cc1COC)CC(NC(=O)C(F)(F)F)C2>>COCc1cc2c(cc1COC)CC(N)C2,,CO,O,[K+].[OH-],,val
US06191124B1,OCc1cnc2sc3cc(F)ccc3n12>>O=Cc1cnc2sc3cc(F)ccc3n12,O=[Mn]=O,CN(C)C=O,Cc1ccccc1,,,val
US20110257198A1,CC(C)(C)OC(=O)N1CCCC[C@H]1CC(=O)CBr.Cc1cnc(N)c(C)c1>>Cc1cc(C)c2nc(C[C@@H]3CCCCN3C(=O)OC(C)(C)C)cn2c1,,CN(C)C=O,,,,val
US20110262352A1,BrCC1COc2ccccc2O1.COCc1cccnc1N1CCNCC1>>COCc1cccnc1N1CCN(CC2COc3ccccc3O2)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100261699A1,Cn1ccc(N)n1.O=C(O)c1nc(Cl)ccc1Cl>>Cn1ccc(NC(=O)c2nc(Cl)ccc2Cl)n1,,c1ccncc1,,CCN=C=NCCCN(C)C,Cl,val
US20120115856A1,Nc1cc(-c2nc3ccccc3o2)ccc1NC1CCOCC1.O=N[O-]>>c1ccc2oc(-c3ccc4c(c3)nnn4C3CCOCC3)nc2c1,,Cl,,[Na+].[OH-],,val
US20060014945A1,COCC(=O)O.N=C(NO)c1ccc(CN(C2CCCCNC2=O)S(=O)(=O)c2ccc(Cl)cc2)cc1>>COCc1nc(-c2ccc(CN(C3CCCCNC3=O)S(=O)(=O)c3ccc(Cl)cc3)cc2)no1,,CN(C)C=O,,O,O=C(n1ccnc1)n1ccnc1,val
US20100029637A1,COC(=O)CCCBr.S=C1N=C2C=CC=CN2C1Cc1csc2ccc(Cl)cc12>>COC(=O)CCCSc1nc2ccccn2c1Cc1csc2ccc(Cl)cc12,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20160244409A1,CC(C)CN1C=CC(C)(C)C(C(=O)CCCCCBr)C1.COc1ccc(C(=O)CC(=O)c2ccc(C(C)(C)C)cc2)cc1>>COc1ccc(C(=O)C(CCCCCC(=O)C2CN(CC(C)C)C=CC2(C)C)C(=O)c2ccc(C(C)(C)C)cc2)cc1,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04167569,C=CC(=O)OC.Cc1cc2nc(N)[nH]c2cc1C>>Cc1cc2nc3n(c2cc1C)CCC(=O)N3,,CCO,,,,val
US06630578B2,COC(=O)c1cc(SC(=O)N(C)C)cc(SC(=O)N(C)C)c1>>COC(=O)c1cc(S)cc(S)c1,,CO,,Cl,C[O-].[Na+],val
US20050192347A1,CC(C)(CCCCBr)COC1CCCCO1.O=C1NC(=O)c2ccccc21>>CC(CCC(C)(C)COC1CCCCO1)N1C(=O)c2ccccc2C1=O,,CN(C)C=O,,[K],,val
US04866086,Cc1ccc(C#N)c[n+]1[O-].O=P(Cl)(Cl)Cl>>N#Cc1ccc(CCl)nc1,,ClCCl,,CCN(CC)CC,,val
US20110257151A1,CNS(=O)(=O)c1cccc(C2Nc3ccc(C(=O)OC)cc3CC2(C)C)c1>>CNS(=O)(=O)c1cccc(C2Nc3ccc(C(=O)O)cc3CC2(C)C)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20060252768A1,CC(C)(C)OC(=O)N1CCC(c2ccc(N3CCCC3)cc2)CC1>>c1cc(N2CCCC2)ccc1C1CCNCC1,,CCOC(C)=O,,Cl,,val
US20140296226A1,[N-]=[N+]=Nc1ccc2c(c1)[C@@]1(CCOC(N)=N1)c1cc(Cl)nc(F)c1O2>>NC1=N[C@@]2(CCO1)c1cc(N)ccc1Oc1c2cc(Cl)nc1F,,CO,,O,[BH4-].[Na+],val
US20090149437A1,CC(C)(C)OC(=O)NCC1CN(C(=O)c2c(Nc3ccc(I)cc3F)sc3ncccc23)C1>>NCC1CN(C(=O)c2c(Nc3ccc(I)cc3F)sc3ncccc23)C1,,ClCCl,O,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20030069434A1,CCCCCN.C[C@]12C[C@H](F)[C@@H]3c4ccc(OCc5ccccc5)cc4C[C@@H](CCCCCl)[C@H]3[C@@H]1CCC2=O>>CCCCCNCCCC[C@@H]1Cc2cc(OCc3ccccc3)ccc2[C@H]2[C@@H](F)C[C@]3(C)C(=O)CC[C@H]3[C@@H]21,,CN(C)C=O,,[I-].[Na+],,val
US05317017,COc1ccc(C2Cc3ccccc3NC(=O)C2N=[N+]=[N-])cc1>>COc1ccc(C2Cc3ccccc3NC(=O)C2N)cc1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20080153852A1,Cc1cc[nH]n1.OC(c1ccc(Cl)cc1I)C(F)(F)F>>Cc1ccn(-c2cc(Cl)ccc2C(O)C(F)(F)F)n1,[Cu]I,CCOC(C)=O,Cc1ccccc1,CN[C@@H]1CCCC[C@H]1NC,O=C([O-])[O-].[K+].[K+],val
US20100305111A1,NC(=NO)C1CC1.O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCSCC2)C1>>O=C(N1CCSCC1)N1CC(c2ccc(OC(F)(F)F)cc2)CC(c2nc(C3CC3)no2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100144772A1,CCOC(=O)C(C)(C)Oc1cccc(NCCc2ccc(C(F)(F)F)cc2)c1>>CC(C)(Oc1cccc(NCCc2ccc(C(F)(F)F)cc2)c1)C(=O)O,,C1CCOC1,O,[Li+].[OH-],,val
US05200422,BrBr.O=c1[nH]c2cc(C(F)(F)F)ccc2n1-c1cc(Cl)ccc1O>>O=c1[nH]c2cc(C(F)(F)F)ccc2n1-c1cc(Cl)cc(Br)c1O,,CC(=O)O,,O,,val
US04812164,CC(C)OC(=O)c1cc(-n2c(Cl)nc(C(F)(F)F)c(F)c2=O)c(F)cc1Cl.CCO>>CCOc1nc(C(F)(F)F)c(F)c(=O)n1-c1cc(C(=O)OC(C)C)c(Cl)cc1F,,CCO,,C,C[O-].[Na+],val
US20100113782A1,CC(C)(C)OC(=O)N1CCN(c2ccc(C(=O)Nc3ccc(C(C)(C)C)cc3)cn2)CC1>>CC(C)(C)c1ccc(NC(=O)c2ccc(N3CCNCC3)nc2)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20020115674A1,O=C(NOCc1ccccc1)c1cc(F)c(N2CCCC2)nc1NC1CC1.O=C(n1ccnc1)n1ccnc1>>O=c1c2cc(F)c(N3CCCC3)nc2n(C2CC2)c(=O)n1OCc1ccccc1,,ClC(Cl)Cl,,,,val
US20040235839A1,CC(C)(C)OC(=O)N1CC(C)(C)OCC1C(=O)Nc1cc(Cl)cc2c1[nH]c1cnccc12>>CC1(C)CNC(C(=O)Nc2cc(Cl)cc3c2[nH]c2cnccc23)CO1,,C1COCCO1,CO,CCOCC,Cl,val
US20090018103A1,Fc1cccc(Br)c1.II>>Fc1cccc(Br)c1I,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US20140329799A1,COc1nc(N2CCOCC2)nc(N[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)c1-c1ncc(F)cn1>>O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1ncc(F)cn1,,CC#N,,C[Si](C)(C)Cl,[I-].[Na+],val
US20070197588A1,CN.O=C1CCc2ccccc2C1c1ccc(Cl)c(Cl)c1>>CNC1CCc2ccccc2C1c1ccc(Cl)c(Cl)c1,,C1CCOC1,CO,Cl,[BH3-]C#N.[Na+],val
US20040059132A1,CI.COc1ccc(CN2C(=O)C(C)(c3cc(CO)ccc3Cl)c3cc(Cl)ccc32)c(OC)c1>>COCc1ccc(Cl)c(C2(C)C(=O)N(Cc3ccc(OC)cc3OC)c3ccc(Cl)cc32)c1,,C1CCOC1,,[H-].[Na+],,val
US20070060607A1,CCOC(=O)c1cnc(N)c2c(COc3cccc(CNc4ccccc4)c3)csc12.NCCO>>Nc1ncc(C(=O)NCCO)c2scc(COc3cccc(CNc4ccccc4)c3)c12,,CS(C)=O,,,,val
US20130045942A1,Nc1cccc2c1Cc1ccccc1-2.Nc1cccc2c1Cc1ccccc1-2.OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O>>OC[C@H]1O[C@@H](n2cnc3c(NC4c5ccccc5-c5ccccc54)ncnc32)[C@H](O)[C@@H]1O,,CCCO,,CCN(CC)CC,Cl,val
US20090093518A1,CC(C)(C)OC(=O)N1CCC(Oc2cc3ccnc(OCc4ccccc4)c3cc2Cl)CC1>>O=c1[nH]ccc2cc(OC3CCNCC3)c(Cl)cc12,,CO,,,,val
US20080004285A1,COc1ccc(-c2ccc3nc(N)[nH]c(=O)c3n2)cc1OC.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>COc1ccc(-c2ccc3nc(N)[nH]c(=S)c3n2)cc1OC,,c1ccncc1,,,,val
US20060160790A1,O=C(NC1=CCC(=NN2CCCC2)C=C1)C(NC(=S)Nc1ccc(Br)cc1)c1ccccc1.c1c[nH]cn1>>O=C(NC1=CCC(=NN2CCCC2)C=C1)C(NC(=S)Nc1ccc(Br)cn1)c1ccccc1,,C1CCOC1,,,,val
US20050124623A1,CCOC(=O)c1c[nH]c2c(Cl)ncnc12>>O=C(O)c1c[nH]c2c(Cl)ncnc12,,C1CCOC1,O,[Li]O,,val
US20130217664A1,CC(C)(C)OC(=O)N1CC(N)C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CC(NS(C)(=O)=O)C1,,ClCCl,,CCN(CC)CC,O,val
US04699905,CC(C)(C)OC(=O)CN1C(=O)[C@@H](N)CSC[C@H]1c1cccs1.CCCCOC(=O)C(Br)CCc1ccccc1>>CCCCOC(=O)C(CCc1ccccc1)N[C@H]1CSC[C@@H](c2cccs2)N(CC(=O)OC(C)(C)C)C1=O,,CCOC(C)=O,ClCCl,,,val
US05416236,CCOC(=O)/C=C(\N)C(F)(F)F.CCOC(=O)Nc1cc(NS(=O)(=O)CC)c(Cl)cc1F>>CCS(=O)(=O)Nc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(F)cc1Cl,,CN(C)C=O,,C[O-].[Na+],,val
US20060094843A1,CCCCCCC1(C(=O)OCC)CCCC1O.Cc1cccc(C(=O)Cl)c1>>CCCCCCC1(C(=O)OCC)CCCC1OC(=O)c1cccc(C)c1,,ClCCl,,c1ccncc1,,val
US20080058327A1,CC(C)N(CC(C(=O)N1CCN(c2ncnc3c2[C@H](C)CC3)CC1)c1ccc(Cl)cc1)C(=O)OC(C)(C)C.Cl.ClCCl>>CC(C)NCC(C(=O)N1CCN(c2ncnc3c2[C@H](C)CC3)CC1)c1ccc(Cl)cc1.Cl.Cl,,ClCCl,,,,val
US20090143358A1,C=C(CC(=O)OC)C(=O)OC.N>>COC(=O)C1CNC(=O)C1,,CO,,,,val
US04946862,[C-]#[N+]C(CC)(CCCc1cc(OC)c(OC)c(OC)c1)c1cccs1>>CCC(CCCc1cc(OC)c(OC)c(OC)c1)(NC)c1cccs1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150126490A1,CI.O=C(NCc1ncccn1)c1ccc(Br)cc1F>>CN(Cc1ncccn1)C(=O)c1ccc(Br)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US20140031345A1,N#Cc1cncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)c1>>NCc1cncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)c1,[Ni],CO,N,,,val
US20120059002A1,CC(=O)Cl.COc1cc(OC)c2c(=O)[nH]c(-c3ccc(OCCN)c(C)c3)nc2c1>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(OCCNC(C)=O)c(C)c3)nc2c1,,ClCCl,,CCN(CC)CC,,val
US20060270609A1,CCOC(=O)c1ccc(CO)cc1.O=C(O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2>>CCOC(=O)c1ccc(COC(=O)CCCNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US05308854,CCc1cc(C=CN2C(=O)c3ccccc3C2=O)c(=O)[nH]c1C>>CCc1cc(CCN2C(=O)c3ccccc3C2=O)c(=O)[nH]c1C,[Pd],C1CCOC1,CO,,,val
US20090137595A1,O=C(Nc1cn2nc(I)ccc2n1)C1CC1.Oc1cncc(Br)c1>>O=C(Nc1cn2nc(Oc3cncc(Br)c3)ccc2n1)C1CC1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20050142225A1,CCc1ccc(=O)c2cc3c([nH]c1-2)-c1cc2c(c(=O)n1C3)COC(=O)[C@]2(O)CC>>CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1,,CCO,,,,val
US04996358,BrBr.O=C1CCCCCCCCCCCN1>>O=C1CC(Br)CCCCCCCCCN1,II,ClC(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US04110447,CC(CCN)c1ccccc1-c1ccccc1.O=CO>>CC(CCNC=O)c1ccccc1-c1ccccc1,,O=CO,,CC(=O)OC(C)=O,,val
US20130225552A1,CC(C)(C(=O)O)c1nccnc1Cl.CC(C)(C)OC(=O)N1CCC(N)CC1>>CC(C)(C)OC(=O)N1CCC(NC(=O)C(C)(C)c2nccnc2Cl)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20020173665A1,CON.O=Cc1cccc(CN(C(=O)c2cc(C(=O)O)c(C(=O)O)cc2C(=O)O)[C@H]2CCCc3ccccc32)c1>>CON=Cc1cccc(CN(C(=O)c2cc(C(=O)O)c(C(=O)O)cc2C(=O)O)[C@H]2CCCc3ccccc32)c1,,c1ccncc1,,Cl,,val
US05411974,O=C(c1ccccc1)N1CCC[C@H]1CO>>O=C[C@@H]1CCCN1C(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,O,val
US20150203515A1,COC(=O)c1ccc2c(C(F)(F)F)c(O[C@H]3CC[C@@H](C(F)(F)F)CC3)ccc2c1>>O=C(O)c1ccc2c(C(F)(F)F)c(O[C@H]3CC[C@@H](C(F)(F)F)CC3)ccc2c1,,CO,,[Na+].[OH-],,val
US20070032522A1,CNC.COc1cc2c(=O)c(C(=O)c3ccc(Cl)nc3)cn(Cc3ccc(S(C)(=O)=O)cc3)c2cc1OC>>COc1cc2c(=O)c(C(=O)c3ccc(N(C)C)nc3)cn(Cc3ccc(S(C)(=O)=O)cc3)c2cc1OC,,O,,c1ccncc1,,val
US20020035115A1,Cc1c(Cl)nc(NCCc2ccccc2)c(=O)n1CC(=O)O>>Cc1cnc(NCCc2ccccc2)c(=O)n1CC(=O)O,,O,,[K+].[OH-],,val
US20120129840A1,C1CCNCC1.COC(=O)Cc1c(C)nc(Cl)nc1-c1ccc(C)cc1>>COC(=O)Cc1c(C)nc(N2CCCCC2)nc1-c1ccc(C)cc1,,CC1CCCO1,,CCN(CC)CC,,val
US07001917B2,Cc1nn(-c2ccc(CCCl)cc2)c(C)c1-c1cccc(C#N)c1.O=S(=O)(O)O>>Cc1nn(-c2ccc(CCCl)cc2)c(C)c1-c1cccc(C(N)=O)c1,,O=S(=O)(O)O,,[Na+].[OH-],,val
US20130090323A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1ncc(Cl)cc1F>>COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1F,,C1COCCO1,,ClCCl,CC(=O)[O-].[K+],val
US20140323558A1,COC(=O)c1ccc(CBr)cc1.O=C1CCc2c1cccc2-c1cccc(Cl)c1>>COC(=O)c1ccc(CC2Cc3c(cccc3-c3cccc(Cl)c3)C2=O)cc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20080312226A1,CC(=O)N(C)c1ccc(N)cn1.O=C(Cl)OCC(Cl)(Cl)Cl>>CC(=O)N(C)c1ccc(NC(=O)OCC(Cl)(Cl)Cl)cn1,,C1CCOC1,,c1ccncc1,,val
US20050209165A1,O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(OS(=O)(=O)C(F)(F)F)cc2)N1c1ccc(F)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20120027874A1,NO.O=Cc1cccc(CBr)c1>>ON=Cc1cccc(CBr)c1,,CCO,,,,val
US20140275178A1,Nc1ccccc1.O=C(O)c1sc(-c2ccccc2)nc1-c1ccccc1>>O=C(Nc1ccccc1)c1sc(-c2ccccc2)nc1-c1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04657898,NCCC(c1ccccc1)c1ccccc1.OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O>>OC[C@H]1O[C@@H](n2cnc3c(NCCC(c4ccccc4)c4ccccc4)ncnc32)[C@H](O)[C@@H]1O,,CCO,,,,val
US20100120798A1,CCCCO.CCN(CC)CC.NC1(C(=O)Nc2cccc(-c3nc4ccccc4o3)c2)CCNCC1.O=c1[nH]c2ncnc(Cl)c2[nH]1>>CO.N.NC1(C(=O)Nc2cccc(-c3nc4ccccc4o3)c2)CCN(c2ncnc3[nH]c(=O)[nH]c23)CC1,,CCCCO,,,,val
US20030087925A1,C=Cc1nc([N+](=O)[O-])ccc1OC.CO>>COc1ccc([N+](=O)[O-])nc1C=O,,ClCCl,,,,val
US08597803B2,C=CCBr.CC(=O)CC(C)=O>>C=CCC(C(C)=O)C(C)=O,,CO,,[Na+].[OH-],,val
US20130017194A1,C#Cc1ncccc1CC(=O)OC.CC(C)(C)OC(=O)N1CCCC(c2ccc(Nc3ncc(C(F)(F)F)c(Cl)n3)cc2)C1>>COC(=O)Cc1cccnc1C#Cc1nc(Nc2ccc(C3CCCN(C(=O)OC(C)(C)C)C3)cc2)ncc1C(F)(F)F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,CN(C)C=O,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100060154A1,O=C(Nc1ccccc1O)c1ccc(I)cc1>>Ic1ccc(-c2nc3ccccc3o2)cc1,,O,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US06204264B1,CN(C)CCN.CNC(=O)c1ccc(Cl)c([N+](=O)[O-])c1>>CNC(=O)c1ccc(NCCN(C)C)c([N+](=O)[O-])c1,,CCOC(C)=O,,,,val
US20030109579A1,C/C(C#Cc1ccc(C#C/C(C)=C/CO)cc1)=C\CO.C1CCOC1.CCOC(=O)N=NC(=O)OCC.CCOC(=O)[C@H](Cc1ccc(O)cc1)OCC.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)[C@H](Cc1ccc(OC/C=C(\C)C#Cc2ccc(C#C/C(C)=C/COc3ccc(C[C@H](OCC)C(=O)OCC)cc3)cc2)cc1)OCC,,C1CCOC1,O,,,val
US06133279,CC(=O)Oc1c(C(C)(C)C)cc2c(c1C(C)(C)C)CC(C)(CI)O2.O=[N+]([O-])c1ccc(O)cc1>>CC(=O)Oc1c(C(C)(C)C)cc2c(c1C(C)(C)C)CC(C)(COc1ccc([N+](=O)[O-])cc1)O2,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20160016937A1,CNCCO.O=C(O)c1ccc2c(c1)N(c1ncc(Br)cn1)CC21CC1>>CN(CCO)C(=O)c1ccc2c(c1)N(c1ncc(Br)cn1)CC21CC1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US05753673,COC1CCC(OC)O1.NCCN1CCOCC1.O=C(O)CC(=O)CC(=O)O>>O=C1CC2CCC(C1)N2CCN1CCOCC1,,O,,Cl,[Na+].[OH-],val
US20110312936A1,Nc1nccc2ccc(C(F)(F)F)cc12.O=C(Cl)OCc1ccccc1>>O=C(Nc1nccc2ccc(C(F)(F)F)cc12)OCc1ccccc1,,ClCCl,,CN1CCOCC1,,val
US20040067964A1,C#CC1CCCO1.CS(=O)(=O)c1ccc(NS(=O)(=O)c2ccccc2)c(I)c1>>CS(=O)(=O)c1ccc2c(c1)cc(C1CCCO1)n2S(=O)(=O)c1ccccc1,,C1COCCO1,,CCN(CC)CC,O,val
US20150025075A1,CO.O=C(O)c1coc2ncccc12>>COC(=O)c1coc2ncccc12,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20090181928A1,COC(=O)CN(c1ccc(OCC(=O)OCC[Si](C)(C)C)cc1OCc1ccccc1)S(=O)(=O)NC(=O)OC(C)(C)C>>COC(=O)CN(c1ccc(OCC(=O)OCC[Si](C)(C)C)cc1OCc1ccccc1)S(N)(=O)=O,,C1COCCO1,Cl,,,val
US20110009406A1,CC(C)(C)OC(=O)CNC(=O)c1c(O)c2c(n(Cc3ccccc3C#N)c1=O)CN(C(=O)c1cscn1)C2>>N#Cc1ccccc1Cn1c2c(c(O)c(C(=O)NCC(=O)O)c1=O)CN(C(=O)c1cscn1)C2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110190489A1,COc1ccc2c(c1)c([Sn](C)(C)C)nn2C.Cc1ccc(S(=O)(=O)n2c(I)cc3c4c(cnc32)cnn4C)cc1>>COc1ccc2c(c1)c(-c1cc3c4c(cnc3n1S(=O)(=O)c1ccc(C)cc1)cnn4C)nn2C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20090054508A1,CCN=C=O.Nc1ccccc1/C=C/c1n[nH]c2ccccc12>>CCNC(=O)Nc1ccccc1/C=C/c1n[nH]c2ccccc12,,C1CCOC1,O,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20150266895A1,CC(C)N1CCc2nc(NC(=O)N[C@H](C)c3ccccc3)cc3c2c1nn3C(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(C)N1CCc2nc(NC(=O)N[C@H](C)c3ccccc3)cc3[nH]nc1c23,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20140088053A1,C[C@]12CC[C@@H]3c4ccc(C(N)=O)cc4CC[C@H]3[C@@H]1C/C(=C\c1cccc(C(N)=O)c1)C2=O>>C[C@]12CC[C@@H]3c4ccc(C(N)=O)cc4CC[C@H]3[C@@H]1C/C(=C\c1cccc(C(N)=O)c1)[C@@H]2O,,CO,ClCCl,[BH4-].[Na+],,val
US06831106B1,CCC1(c2ccc(Br)c(C)c2)OCCO1.O=Cc1cccc(B(O)O)c1>>CCC1(c2ccc(-c3cccc(C=O)c3)c(C)c2)OCCO1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20150291595A1,COc1cccc(S)c1.C[Si](C)(C)CCOCn1cc(Br)c2c(Cl)ncnc21>>COc1cccc(Sc2cn(COCC[Si](C)(C)C)c3ncnc(Cl)c23)c1,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130281412A1,COC(=O)Cl.O=C(Nc1ccc(F)cc1F)c1ccccc1O>>O=c1oc2ccccc2c(=O)n1-c1ccc(F)cc1F,,c1ccncc1,,Cl,,val
US20070155805A1,BrC(Br)(Br)Br.Cc1c(/C=C/CO)sc2ccc(C(F)(F)F)cc12>>Cc1c(/C=C/CBr)sc2ccc(C(F)(F)F)cc12,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060030595A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C(c1ccccc1)C1CCCN1>>COC(=O)C(c1ccccc1)C1CCCN1C(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20140088080A1,Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@H](CC(=O)OC(C)(C)C)CC(C)C>>Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@H](CC(=O)O)CC(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100081825A1,COCCBr.COc1cccc(C(=O)NC2CCN(Cc3ccc4ccc(O)cc4c3)CC2)c1>>COCCOc1ccc2ccc(CN3CCC(NC(=O)c4cccc(OC)c4)CC3)cc2c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20030004161A1,CCC(=O)Nc1ccc(Sc2nc(Nc3cc(C)n[nH]3)cc(C(=O)OC)n2)cc1>>CCC(=O)Nc1ccc(Sc2nc(CO)cc(Nc3cc(C)n[nH]3)n2)cc1,,C1CCOC1,,[BH4-].[Li+],,val
US20090181971A1,NO.O=C(O)CCCCCCC(=O)c1ccc2ccccc2c1>>O=C(CCCCCCC(=O)c1ccc2ccccc2c1)NO,,CCN(CC)CC,,Cl,,val
US20040229868A1,BrCC1CCCCC1.c1cn[nH]c1>>c1cnn(CC2CCCCC2)c1,,CN(C)C=O,,[H-].[Na+],,val
US04383113,CCCCC(C)O.COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(C)nc(OC)n1>>CCCCC(C)OC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(C)nc(OC)n1,,Cc1ccccc1,,C[Al](C)C,,val
US20140194415A1,N#CCc1ccc(-c2ccc3cccnc3c2)cc1.O=C1CCC(=O)N1Br>>N#CC(Br)c1ccc(-c2ccc3cccnc3c2)cc1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US06235739B1,COc1ccc(C=O)cc1O.OCCc1ccccc1>>CCOc1cccc(Oc2cc(OC)ccc2C=O)c1,,C1CCOC1,CCOCC,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110028520A1,CC(C)(N)c1cccc(C#N)n1>>CC(C)(N)c1cccc(C#N)n1,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US20120101080A1,CC(C)CC(=O)Cl.c1ccc(C2CNCCO2)cc1>>CC(C)CC(=O)N1CCOC(c2ccccc2)C1,,ClCCl,,CCN(CC)CC,,val
US20100286114A1,Nc1ccccc1NC(=O)c1cc(Br)ccc1F>>Fc1ccc(Br)cc1-c1nc2ccccc2[nH]1,,CC(=O)O,,,,val
US20130096118A1,COC(=O)c1ccc2c(c1)[nH]c1c(C#N)c[nH]c(=O)c12.O=P(Cl)(Cl)Cl>>COC(=O)c1ccc2c(c1)[nH]c1c(C#N)cnc(Cl)c12,,C1COCCO1,,,,val
US06166006,Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CCl)cc2)CCO3)cc1.Nc1ccccc1>>Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CNc4ccccc4)cc2)CCO3)cc1,,CN(C)C=O,,,,val
US04709093,Cc1ccccc1NC(=O)C(C)(C)C.NC=Cc1ccccc1>>CNC(Cc1ccccc1NC(=O)C(C)(C)C)c1ccccc1,,C1CCOC1,CCOCC,CCCCCC,[Li]CCCC,val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(C=O)ccc21.CC(N)CO>>CC(CO)NCc1ccc2c(c1)cc(-c1ccc(Cl)c3c1C(=O)NC3)n2C(=O)OC(C)(C)C,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140206618A1,CC(C)(C)OC(=O)N1CCN(CC(O)c2ccc(F)c(C#N)c2F)[C@H](CO)C1>>CC(C)(C)OC(=O)N1CCN2CC(c3ccc(F)c(C#N)c3F)OC[C@@H]2C1,,c1ccccc1,,CCCCP(=CC#N)(CCCC)CCCC,,val
US05516774,CC(C)CC(=O)Cl.COc1cc(C(=O)N2Cc3cccn3Cc3ccccc32)ccc1N>>CC(C)CC(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1,,ClCCl,,CCN(CC)CC,,val
US05604253,CCOC(=O)CC(C)c1c(C)n(Cc2ccc(Br)cc2)c2ccc(OC)cc12>>COc1ccc2c(c1)c(C(C)CC(=O)O)c(C)n2Cc1ccc(Br)cc1,,CCO,,O,[K+].[OH-],val
US20100311761A1,O=C(Cc1ccc(Cl)c(Cl)c1)N1CCNC2CCCC(N3CCCC3)C21.O=Cc1cnc[nH]1>>O=C(Cc1ccc(Cl)c(Cl)c1)N1CCN(Cc2cnc[nH]2)C2CCCC(N3CCCC3)C21,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150218156A1,CO.O=c1[nH]c(=O)n(CCc2ccccc2)nc1O>>COc1cccc(CCn2nc(O)c(=O)[nH]c2=O)c1,,CCOC(C)=O,,,,val
US20020160996A1,CC(=Cc1ccc(C(C)C)cc1)CBr.Cc1cc(O)c(C)c(C)c1NC=O>>CC(=Cc1ccc(C(C)C)cc1)COc1cc(C)c(NC=O)c(C)c1C,,CN(C)C=O,,O,[H-].[Na+],val
US20090099187A1,C=O.CO.COc1ccc(Cl)cc1NS(=O)(=O)c1ccc(OC)c2c1OC[C@H](N)C2>>COc1ccc(Cl)cc1NS(=O)(=O)c1ccc(OC)c2c1OC[C@H](N(C)C)C2,CC(=O)O,CO,,[BH3-]C#N.[Na+],,val
US05750764,COC(=O)C(C)=O.COc1ccc2ccccc2c1>>COC(=O)C(C)(O)c1ccc2cc(OC)ccc2c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20160002204A1,CC(=O)Nc1ccn(CCCCc2nnc(NC(=O)Cc3ccccc3)s2)c(=O)n1>>Nc1ccn(CCCCc2nnc(NC(=O)Cc3ccccc3)s2)c(=O)n1,,CO,N,,,val
US20110021537A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(Cl)Oc1ccccc1>>CC(C)(C)OC(=O)N1CCN(C(=O)Oc2ccccc2)CC1,,ClCCl,,CCN(CC)CC,O,val
US20160046635A1,CCCNc1nc(NC)c2nc(Cl)nc(NC)c2n1.CNCCO>>CCCNc1nc(NC)c2nc(N(C)CCO)nc(NC)c2n1,,CCCCO,,O=C([O-])O.[Na+],,val
US20080275097A1,CC(C)(C)OC(=O)Cn1nnc2c(Oc3cc(Cl)cc(C#N)c3)c(Cl)ccc21>>N#Cc1cc(Cl)cc(Oc2c(Cl)ccc3c2nnn3CC(=O)O)c1,,O=C(O)C(F)(F)F,,,,val
US20100267707A1,Cn1cc(S(=O)(=O)Cl)cn1.Fc1ccc2[nH]cc(-c3ccnc(Nc4ccc(N5CCNCC5)cc4)n3)c2c1>>Cn1cc(S(=O)(=O)N2CCN(c3ccc(Nc4nccc(-c5c[nH]c6ccc(F)cc56)n4)cc3)CC2)cn1,CN(C)c1ccncc1,CN(C)C=O,,CCN(CC)CC,,val
US04584290,CCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(C=CSc3ccccn3)CS[C@H]12)c1nsc(N)n1.CI>>CCON=C(C(=O)NC1C(=O)N2C(C(=O)[O-])=C(C=CS[CH2+]3C=CC=CN3C)CS[C@H]12)c1nsc(N)n1.I,,CCOC(C)=O,,CN(C)C=O,,val
US20040116518A1,CC(C)(C)OC(=O)CBr.CC(C)(C)OC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c([N+](=O)[O-])c2)CC1>>O=C(O)CN1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c([N+](=O)[O-])c2)CC1,,CC#N,ClCCl,O=C(O)C(F)(F)F,,val
US20110319394A1,O=[N+]([O-])c1cccnc1Nc1ccc(Nc2nc3ccccc3o2)cc1>>Nc1cccnc1Nc1ccc(Nc2nc3ccccc3o2)cc1,[Pd],CO,,,,val
US20120046255A1,COc1ccc(C(C)=O)cc1F.NOCc1cccc(F)c1>>COc1ccc(C(C)=NOCc2cccc(F)c2)cc1F,,CCO,,Cl,c1ccncc1,val
US20150376160A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4sc(Cl)cc4NC(=O)O[C@H](C)c4ccc(F)cc4F)cc3)cc2)CC1>>C[C@@H](OC(=O)Nc1cc(Cl)sc1-c1ccc(-c2ccc(C3(C(=O)O)CC3)cc2)cc1)c1ccc(F)cc1F,,CC(C)O,,CCOC(C)=O,[Na+].[OH-],val
US20100267712A1,CCOC(=O)c1cc(OC)ccc1CBr.Cn1ccc2cc(N)ncc21>>COc1ccc2c(c1)C(=O)N(c1cc3ccn(C)c3cn1)C2,,CCO,,CCN(C(C)C)C(C)C,,val
US20150031674A1,CC(C)(C)OC(=O)N1CCO[C@@H](CO)C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCO[C@@H](COS(C)(=O)=O)C1,,CCOC(C)=O,ClCCl,,,val
US20010051632A1,COc1ccc(-c2cc3c(C)cccn3c2)cc1>>Cc1cccn2cc(-c3ccc(O)cc3)cc12,,CC(=O)O,,Br,,val
US20080085890A1,CN(CCO)c1ccc(N)cc1.CO/C=C1/C(=O)NC(=O)c2ccc(Br)cc21>>CN(CCO)c1ccc(N/C=C2\C(=O)NC(=O)c3ccc(Br)cc32)cc1,,CN(C)C=O,,CCN(CC)CC,,val
US20120101100A1,CC(=O)O.CCCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2cc(C(=O)O)cnc2OCCN(C(C)C)C(C)C)cn1.NN>>CCCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2cc(-c3nnc(C)o3)cnc2OCCN(C(C)C)C(C)C)cn1,,O=P(Cl)(Cl)Cl,,,,val
US04886835,CCOC(=O)C(O)=CC=C(Sc1ccc2ccccc2c1)C(=O)OCC>>CCOC(=O)C(=CC=C(O)C(=O)O)Sc1ccc2ccccc2c1,,CCO,,[Na+].[OH-],,val
US20050014812A1,CC(=O)Nc1ccc(OC(C)=O)cc1N.Clc1cc(-c2ccccc2)ccc1CBr>>CC(=O)Nc1ccc(OC(C)=O)cc1NCc1ccc(-c2ccccc2)cc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160060257A1,CC(C)(C)OC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=C1CCC(=O)CC1>>CC(C)(C)OC(=O)C=C1CCC(=O)CC1,,Cc1ccccc1,,,,val
US20060014945A1,COC(=O)c1ccc(CN([C@@H]2CC(C)(C)CCNC2=O)S(=O)(=O)c2ccc(Cl)cc2)c(F)c1>>CC1(C)CCNC(=O)[C@H](N(Cc2ccc(C(=O)O)cc2F)S(=O)(=O)c2ccc(Cl)cc2)C1,,C1CCOC1,,[Na+].[OH-],,val
US20150210697A1,COc1ccc(CN(c2nc(Nc3cc(C#N)cc(-c4c(C)nn(C)c4C)c3Cl)nn3c(C#N)cnc23)C2CC2)cc1>>Cc1nn(C)c(C)c1-c1cc(C#N)cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20130150339A1,COc1ccc(CNc2nccs2)cc1.Cc1cc2c(Cl)ccnc2cc1S(=O)(=O)Cl>>COc1ccc(CN(c2nccs2)S(=O)(=O)c2cc3nccc(Cl)c3cc2C)cc1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20090221611A1,CO.O=C(O)c1cnc(O)cn1.O=S(Cl)Cl>>COC(=O)c1cnc(Cl)cn1,,Cc1ccccc1,,CN(C)C=O,,val
US05362742,CC(=O)Oc1c(C(C)C)cc(C(=O)Nc2cnc3c(C)cc(C)cc3c2-c2ccccc2Cl)cc1C(C)C>>Cc1cc(C)c2ncc(NC(=O)c3cc(C(C)C)c(O)c(C(C)C)c3)c(-c3ccccc3Cl)c2c1,,CO,,[Na+].[OH-],,val
US20060166899A1,BrCc1ccccc1.Cc1cc(OCCC(=O)O)ccc1C=O>>Cc1cc(OCCC(=O)OCc2ccccc2)ccc1C=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.O=Cc1c(O)ccc2ccccc12>>COc1cc2nccc(Oc3ccc4ccccc4c3C=O)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,O,,val
US20030055087A1,COC(=O)c1cc(=O)c2cc([N+](=O)[O-])ccc2[nH]1.O=C=NS(=O)(=O)Cl>>COC(=O)c1cc(N)c2cc([N+](=O)[O-])ccc2n1,,CC#N,,CO,,val
US20060241115A1,O=S(=O)(c1ccccc1)N(F)S(=O)(=O)c1ccccc1.Oc1ccc2cc(Br)ccc2c1>>Oc1ccc2cc(Br)ccc2c1F,,CN(C)C=O,,,,val
US20120295924A1,CCN=C=NCCCN(C)C.Cc1scc2c1c(=O)n(C)c(=O)n2C.Nc1cc(-c2ccc(Cl)cc2)no1.On1nnc2ccccc21>>Cn1c(=O)c2c(CC(=O)Nc3cc(-c4ccc(Cl)cc4)no3)csc2n(C)c1=O,CN(C)c1ccncc1,ClCCCl,,Cl,,val
US20090111789A1,CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(C(=O)OC)CC1>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(C(=O)O)CC1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20040132694A1,COc1ccccc1N.NC(=O)c1c(Cl)ccc(Nc2c(Cl)c(=O)c2=O)c1O>>COc1ccccc1Nc1c(Nc2ccc(Cl)c(C(N)=O)c2O)c(=O)c1=O,,CS(C)=O,,,,val
US20120264731A1,COC(=O)c1cc(C2CCCN2C(=O)OC(C)(C)C)c2oc(N3CCOCC3)cc(=O)c2c1>>COC(=O)c1cc(C2CCCN2)c2oc(N3CCOCC3)cc(=O)c2c1,,C1COCCO1,,Cl,ClCCl,val
US20100004245A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)Cc1cncc(Br)c1>>COC(=O)Cc1cncc(B2OC(C)(C)C(C)(C)O2)c1,Cl[Pd]Cl,CN(C)C=O,,CC(=O)[O-].[K+],,val
US20130310375A1,CC(C)(C)OC(=O)Cc1cnc(-c2ccnc(F)c2)c(F)c1>>O=C(O)Cc1cnc(-c2ccnc(F)c2)c(F)c1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccc(F)cc4F)nc(Cl)c3n2)cc1.COc1ccc(N)cc1OC>>COc1ccc(Nc2nc(-c3ccc(F)cc3F)nc3cn[nH]c23)cc1OC,C1COCCO1,CO,,Cl,,val
US20150307451A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)c1cc(Br)c(C)c(C)c1O>>COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)c(C)c(C)c1O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,,O,CC(=O)[O-].[K+],val
US20030114311A1,O=Cc1cc(Cl)c(Cl)c(Cl)n1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>Clc1cc(-c2cnco2)nc(Cl)c1Cl,,CO,,O=C([O-])[O-].[K+].[K+],,val
US05385902,C#CC(O)I.O=C(O)C(=O)c1ccccc1>>O=C(OCC#CI)C(=O)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20090209607A1,CCn1ncc(Cl)c1-c1csc(C(=O)O)c1.N[C@@H](Cc1ccccc1C(F)(F)F)CN1C(=O)c2ccccc2C1=O>>CCn1ncc(Cl)c1-c1csc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)c1,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US04478849,COC(=O)c1ccc(CC(C)NCC(O)c2ccc(OCc3ccccc3)c(CS(C)(=O)=O)c2)cc1>>COC(=O)c1ccc(CC(C)NCC(O)c2ccc(O)c(CS(C)(=O)=O)c2)cc1,[Pd],CCO,,,,val
US20100016319A1,C1COCCN1.CC(C)(C)c1cc(NC(=O)NCc2ccccc2Oc2ccnc(Cl)n2)n(-c2cccnc2)n1>>CC(C)(C)c1cc(NC(=O)NCc2ccccc2Oc2ccnc(N3CCOCC3)n2)n(-c2cccnc2)n1,,CCO,,,,val
US20150126490A1,CCOC(=O)c1cnc(N)c(-c2ccc(C(=O)OC(C)(C)C)c(F)c2)n1.O=C(O)C(F)(F)F>>CCOC(=O)c1cnc(N)c(-c2ccc(C(=O)O)c(F)c2)n1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20050043248A1,CCCCCC1CNC(C(=O)NC(C(C)C)C2OC(SC)C(O)C(O)C2O)C1.CCOC=N>>CCCCCC1CC(C(=O)NC(C(C)C)C2OC(SC)C(O)C(O)C2O)N(C=N)C1,,C1COCCO1,,[Na+].[OH-],,val
US20100216860A1,COc1ccc(F)c2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1>>NC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)ccc(F)c32)c1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US04302238,CC(C)(C(=O)Cl)C(=O)Cl.ONCc1cc(Cl)ccc1Cl>>CC1(C)C(=O)ON(Cc2cc(Cl)ccc2Cl)C1=O,,Cc1ccccc1,,c1ccncc1,,val
US20100190764A1,Cl.O=C(O)C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1>>Cl.O=C(O)C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1,,C1CCOC1,,,,val
US04597902,C1CCOC1.CC(C)NCCCCS(=O)(=O)c1ccccc1.CCN(CC)CCN.O=C(n1ccnc1)n1ccnc1>>CC(C)N(CCCCS(=O)(=O)c1ccccc1)C(=O)NCCN(C)C.O,,C1CCOC1,ClC(Cl)Cl,,,val
US20070225303A1,C=Cc1cccc(C(=O)O)c1.CI>>C=Cc1cccc(C(=O)OC)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150105373A1,CC(C)(C)OC(=O)NC(CN)c1ccc(OC(F)(F)F)cc1.O=C1OC(=O)c2ccccc21>>CC(C)(C)OC(=O)NC(CN1C(=O)c2ccccc2C1=O)c1ccc(OC(F)(F)F)cc1,,Cc1ccccc1,,,,val
US20130261089A1,COCCl.Oc1ccc(C2CC2)cc1>>COCOc1ccc(C2CC2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20090042929A1,C#CCCl.Sc1cc(Cl)ccc1Cl>>C#CCSc1cc(Cl)ccc1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160176825A1,COc1cc(N2CCN(C)CC2)ccc1NC(=O)OC(C)(C)C.Clc1cc(Cl)ncn1>>COc1cc(N2CCN(C)CC2)ccc1N(C(=O)OC(C)(C)C)c1cc(Cl)ncn1,,C1CCOC1,,[H-].[Na+],,val
US20070278941A1,COC(=O)c1ccc(C(=O)OC)c(-c2ccc(N(c3ccccc3)c3ccccc3)cc2)c1Nc1ccccc1>>OCc1ccc(CO)c(-c2ccc(N(c3ccccc3)c3ccccc3)cc2)c1Nc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05849911,COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2nnn(C(C)(C)c3ccccc3)n2)cc1)NC(=O)OC(C)(C)C)C(C)(C)C.Cl>>COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(N)Cc1ccc(-c2nnn(C(C)(C)c3ccccc3)n2)cc1)C(C)(C)C.Cl,,CC#N,,,,val
US06004959,COc1cc(OC(C)C)ccc1-c1c(OC(C)C)cccc1C1=[N+](C)C(C)(C)CO1.[OH-]>>COc1cc(OC(C)C)ccc1-c1c(OC(C)C)cccc1C(=O)O,,CO,,[I-].[Na+],,val
US20160237081A1,NNc1nccc(OCC2(c3ccccc3)CCCCC2)c1C(F)(F)F.O=C(Cl)CC1CC1>>O=C(CC1CC1)NNc1nccc(OCC2(c3ccccc3)CCCCC2)c1C(F)(F)F,,ClCCl,O,CCN(CC)CC,,val
US06495645B1,CCC(N)C(=O)O.Cc1ccc(S(=O)(=O)O)cc1.OCc1ccccc1.c1ccccc1>>CC(N)CC(=O)OCc1ccccc1.Cc1ccc(S(=O)(=O)O)cc1,,c1ccccc1,,O,,val
US20140235608A1,CCOC(=O)C1=C(O)C(=O)NCC1>>CCOC(=O)c1cc[nH]c(=O)c1O,[Pd],Cc1ccccc1C,,,,val
US20160060257A1,COC(=O)CBr.O=[N+]([O-])c1cn[nH]c1>>COC(=O)Cn1cc([N+](=O)[O-])cn1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130045954A1,C=C(C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CCO.C[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2[C@H]1C>>COc1cc(C=O)ccc1O,,CCO,,O,,val
US06218431B1,Cc1ccccc1/C=C/c1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccc(F)cc1>>Cc1ccccc1CCc1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccc(F)cc1,,CCCCCC,CCOC(C)=O,,,val
US20130317023A1,Cn1cc(S(=O)(=O)Cl)cn1.Nc1ccc(F)c(Nc2ncccc2-c2ncnc3c2ncn3C2CCCCO2)c1F>>Cn1cc(S(=O)(=O)Nc2ccc(F)c(Nc3ncccc3-c3ncnc4c3ncn4C3CCCCO3)c2F)cn1,,ClCCl,,c1ccncc1,,val
US05387585,CC#N.Cc1cccc(N)c1C#N>>Cc1nc(N)c2c(C)cccc2n1,,C1COCCO1,,Cl,,val
US20080312226A1,O=C(Nc1ccc(NC(=O)C(F)(F)F)cc1)OCC(Cl)(Cl)Cl.c1ccc(-c2csc(N3CCNCC3)n2)cc1>>O=C(Nc1ccc(NC(=O)C(F)(F)F)cc1)N1CCN(c2nc(-c3ccccc3)cs2)CC1,,O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20100125062A1,Fc1ncccc1C1CCC2(CC1)OCCO2>>O=C1CCC(c2cccnc2F)CC1,,CC(C)=O,,Cl,,val
US06337351B1,C=O.Nc1cccc(Br)c1.[BH3-]C#N>>CN(C)c1cccc(Br)c1,,CC#N,CCOCC,CC(=O)O,,val
US20100075994A1,CN1C(C)(C)C=C(c2ccc(O)cc2)CC1(C)C>>CN1C(C)(C)CC(c2ccc(O)cc2)CC1(C)C,[Pd],CO,,,,val
US20100179168A1,COc1ccc(N)cc1NS(=O)(=O)c1ccc(Br)cc1Cl.C[C@@H](C(=O)O)N(C)C(=O)OC(C)(C)C>>COc1ccc(NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)cc1NS(=O)(=O)c1ccccc1Cl,,CN(C)C=O,,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US04731358,CSc1cc2c(cn1)[nH]c1ccc([N+](=O)[O-])cc12>>Nc1ccc2[nH]c3cnccc3c2c1,[Ni],CN1CCCC1=O,,,,val
US20150018363A1,Cc1c(C2CC2)nc2ccc(-n3ccc(O)cc3=O)cn12.OCc1csc(Cl)c1>>Cc1c(C2CC2)nc2ccc(-n3ccc(OCc4csc(Cl)c4)cc3=O)cn12,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US04723006,CNC.Nc1nc(Cl)cc(CCl)n1>>CN(C)c1cc(CCl)nc(N)n1,,CO,,Cl,[Na],val
US20160060258A1,CC(C)(C)OC(=O)NCc1cccc(Nc2ncc3c(=O)n(-c4c(Cl)cccc4Cl)ccc3n2)c1>>NCc1cccc(Nc2ncc3c(=O)n(-c4c(Cl)cccc4Cl)ccc3n2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150240295A1,CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)C(=O)CCC(=O)O.COS(=O)(=O)OC>>CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)C(=O)CCC(=O)OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120321559A1,C1CCNCC1.CCCCO.COc1ccc2c(c1)C1CCCN1C(=O)C2c1ccc(SC)cc1>>CSc1ccc(C2C(=O)N3CCCC3c3cc(OCCCN4CCCCC4)ccc32)cc1,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US20070167444A1,COC(=O)c1ccc(C(O)C(C)C(=O)OC)c(N)c1>>COC(=O)c1ccc2cc(C)c(=O)[nH]c2c1,,C1COCCO1,,Cl,,val
US20150376136A1,CC1(C2CCC2)NC(=O)N(CC(=O)c2ccccc2)C1=O.CI>>CN1C(=O)N(CC(=O)c2ccccc2)C(=O)C1(C)C1CCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04010177,C#CCNCc1nnc2n1-c1ccc(Cl)cc1C(c1c(F)cccc1F)=NC2.C=O>>O=C(c1ccccc1)c1ccccc1,,O=CO,,,,val
US20130059834A1,CC(NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CCN4CCOCC4)c4cc(Cl)ccc34)nc12)c1cccnc1>>CC(NC(=O)c1c[nH]c2ncc(-c3nn(CCN4CCOCC4)c4cc(Cl)ccc34)nc12)c1cccnc1,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US04006009,C=CCCN1CCC(O)N(c2nnc(OC)s2)C1=O.O=C(OC(=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1>>C=CCCN1CCC(OC(=O)c2ccc(Cl)cc2)N(c2nnc(OC)s2)C1=O,,c1ccccc1,,Cc1ccccc1S(=O)(=O)O,,val
US20140038999A1,CI.Cc1nccc2c1c(=O)n(C)c1cc(OC[C@H](CC(C)C)NC(=O)OC(C)(C)C)ccc21>>Cc1nccc2c1c(=O)n(C)c1cc(OC[C@H](CC(C)C)N(C)C(=O)OC(C)(C)C)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20130211079A1,CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C=O.NCc1ccc(Cl)cc1.[C-]#[N+]C(c1ccccc1)S(=O)(=O)c1ccc(C)cc1>>CCOC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(-c2ccccc2)ncn1Cc1ccc(Cl)cc1,,CCO,,CCN(CC)CC,,val
US20130336921A1,NC(N)=S.O=C(CBr)c1cccc(C(F)(F)F)c1>>Nc1ncc(-c2cccc(C(F)(F)F)c2)s1,,CO,,,,val
US20120309739A1,CC(C)(C)OC(=O)N1CC(=O)C1.CC(C)(C)S(N)=O>>CC(C)(C)OC(=O)N1CC(=NS(=O)C(C)(C)C)C1,,ClCCCl,ClCCl,O=C([O-])O.[Na+],,val
US04059583,II.NC(N)=S.c1ccc2[nH]ccc2c1>>I.N=C(N)Sc1c[nH]c2ccccc12,,CO,,[I-].[K+],,val
US05256675,Nc1ccc(S(=O)Cc2csc(N)n2)cc1.O=C(OO)c1cccc(Cl)c1>>Nc1ccc(S(=O)(=O)Cc2csc(N)n2)cc1,,CN(C)C=O,,,,val
US20080214503A1,CCOC(=O)CC(=O)Cl.CCOC(=O)c1ncc(Cc2ccc(F)cc2)cc1N>>CCOC(=O)CC(=O)Nc1cc(Cc2ccc(F)cc2)cnc1C(=O)OCC,,ClCCCl,,,,val
US05616586,COC(=O)C1Cc2ccccc2N1.N>>NC(=O)C1Cc2ccccc2N1,,CO,,,,val
US20090291973A1,CCOC(=O)C(CC)c1ccc(Cl)cc1.NN>>CCC(C(=O)NN)c1ccc(Cl)cc1,,CCO,,O,,val
US20140066424A1,CC(=N)N.NNC(=O)c1ncc(-c2ccc(OC(F)(F)F)cc2)o1>>Cc1nc(-c2ncc(-c3ccc(OC(F)(F)F)cc3)o2)n[nH]1,,C1CCOC1,,Cl,[Na+].[OH-],val
US04492692,C=CCn1ccnc1NC1C(=O)N2C(C(=O)O)=C(COC(C)=O)CS[C@H]12.Sc1nncs1>>C=CCn1ccnc1NC1C(=O)N2C(C(=O)O)=C(CSc3nncs3)CS[C@H]12,,CC#N,,CCOCC,FB(F)F,val
US20070032515A1,CC(C)(C)OC(=O)N1CCC(COS(C)(=O)=O)CC1.COc1c(O)cc(F)c2c(-c3ccc(OCc4ccccc4)c(C)c3)nc3c(c(C)nn3C(C)(C)C)c12>>COc1c(OCC2CCN(C(=O)OC(C)(C)C)CC2)cc(F)c2c(-c3ccc(OCc4ccccc4)c(C)c3)nc3c(c(C)nn3C(C)(C)C)c12,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20100222318A1,CC(C)S(=O)(=O)c1ccc(B(O)O)cc1.Cc1ccsc1-c1nnc(-c2nc(Br)cnc2N)o1>>Cc1ccsc1-c1nnc(-c2nc(-c3ccc(S(=O)(=O)C(C)C)cc3)cnc2N)o1,[Pd],CN(C)C=O,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])[O-].[Na+].[Na+],val
US20060252768A1,CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)C(c2ccc(-c3ncon3)cc2)C1.Cl.ClCCl>>Cl.Cl.c1nc(-c2ccc(C3CNCCN3)cc2)no1,,CCOC(C)=O,ClCCl,,,val
US20080103142A1,CSc1nccc(Cl)n1.c1ccc2[nH]nnc2c1>>CSc1nccc(-n2nnc3ccccc32)n1,,O,,CN(C)C=O,[H-].[Na+],val
US20160137696A1,CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCNC(=O)OCC1c2ccccc2-c2ccccc21>>O=C(O)CCCCCCCCCCCCCCCCNC(=O)OCC1c2ccccc2-c2ccccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070203201A1,COC(=O)c1ccccc1-n1nc(C(F)(F)F)cc1C(=O)Nc1c(C)cccc1C(=O)NC(C)C>>Cc1cccc(C(=O)NC(C)C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ccccc1CO,,C1CCOC1,,[BH4-].[Li+],,val
US20020156075A1,CC1(C(=O)Cl)CCCCC1.COc1ccccc1N1CCN(C[C@H](N)CC2CCCCC2)CC1>>COc1ccccc1N1CCN(C[C@@H](CC2CCCCC2)NC(=O)C2(C)CCCCC2)CC1,,ClCCl,,CCN(CC)CC,,val
US20140296316A1,C=O.CCOC(=O)C(C)n1cc(-c2cc(F)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1>>CC(CO)(C(=O)O)n1cc(-c2cc(F)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1,,CN(C)C=O,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20110251173A1,O=C(c1c(Cl)ncnc1Cl)N(CCO)c1ccc(Br)cc1>>O=C1c2c(Cl)ncnc2OCCN1c1ccc(Br)cc1,,CC#N,,CCN(CC)CC,,val
US20070265318A1,O=C1C(C(F)(F)F)=C2c3ccc4[nH]nnc4c3CC23CCC1C3>>O=C1C(C(F)(F)F)=C2c3ccc4[nH]nnc4c3C[C@@]23CC[C@@H]1C3,,CCO,CO,,,val
US20120214803A1,COc1ccc([N+](=O)[O-])c(S(=O)(=O)O)c1.O=S(Cl)Cl>>COc1ccc([N+](=O)[O-])c(S(=O)(=O)Cl)c1,,CN(C)C=O,,,,val
US20100099755A1,COC(Cl)Cl.Oc1ccc(C2OCCO2)cc1Br>>COCOc1ccc(C2OCCO2)cc1Br,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080207616A1,Cc1cc(C(=O)Cl)n(C(C)(C)C)n1.Cc1ccc(N)cc1NC(=O)c1ccc2nccnc2c1>>Cc1cc(C(=O)Nc2ccc(C)c(NC(=O)c3ccc4nccnc4c3)c2)n(C(C)(C)C)n1,,ClCCl,,CCN(CC)CC,Cl,val
US04496572,COC(=O)c1ccc2c(C)csc2c1.O=C1CCC(=O)N1Br>>COC(=O)c1ccc2c(CBr)csc2c1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US04648898,CCNc1nc(Cl)nc(NCC)n1.NC(N)=S>>CCNc1ncnc(S)n1,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20090181965A1,NC(=S)Nc1ccc(-n2cncn2)cc1.O=C1C(Br)CCCC1c1ccccc1>>c1ccc(C2CCCc3sc(Nc4ccc(-n5cncn5)cc4)nc32)cc1,,CCO,,,,val
US05686445,Nc1ccc(C(=O)N2Cc3ccccc3Cc3ccccc32)cc1.O=C(Cl)c1cc(Cl)ccc1Cl>>O=C(Nc1ccc(C(=O)N2Cc3ccccc3Cc3ccccc32)cc1)c1cc(Cl)ccc1Cl,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20030092749A1,Cc1cccc(C(Br)C(=O)c2ccc3c(c2)n(C)c(=O)n3C(C)C)c1.N=C(N)c1cnccn1>>Cc1cccc(-c2[nH]c(-c3cnccn3)nc2-c2ccc3c(c2)n(C)c(=O)n3C(C)C)c1,,O,,CN(C)C=O,Cl,val
US20090264406A1,CC(=O)Cl.Fc1cc2ncccc2cc1Cc1cnc2ccc(-c3cnn(C4CCNCC4)c3)nn12>>CC(=O)N1CCC(n2cc(-c3ccc4ncc(Cc5cc6cccnc6cc5F)n4n3)cn2)CC1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20090253669A1,COC(=O)NC1(c2cccnc2)CCC2(CC1)OCCO2>>CNC1(c2cccnc2)CCC2(CC1)OCCO2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070032525A1,O=C1Nc2ccc(F)cc2S(=O)(=O)N1>>Nc1ccc(F)cc1S(N)(=O)=O,,O=S(=O)(O)O,,[Na+].[OH-],,val
US04628057,CCC[C@@H]1N[C@H](C(=O)O)Cc2c1[nH]c1ccccc21.CI.S=C=S>>CCC[C@H]1c2[nH]c3ccccc3c2C[C@@H](C(=O)O)N1C(=S)SC,,CO,,CCN(CC)CC,,val
US20120046278A1,Nc1nc(N2CCNCC2)c2nc(-c3ccc(F)cc3)sc2n1.O=C(Cl)COc1ccc(Cl)cc1>>Nc1nc(N2CCN(C(=O)COc3ccc(Cl)cc3)CC2)c2nc(-c3ccc(F)cc3)sc2n1,,CN(C)C=O,,c1ccncc1,,val
US20150376169A1,Cc1cccc(B(O)O)c1.O.O=C1CCCc2cc(Br)ccc21>>Cc1cccc(-c2ccc3c(c2)OCCC3=O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US04820715,CC(=O)OC(C)=O.CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCCN>>CC(=O)NCCOc1cc(N)c(Cl)cc1C(=O)NCCN(C)C,,ClCCl,,,,val
US20080249104A1,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1.O=S(=O)(O)c1ccccc1>>Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1.O=S(=O)([O-])c1ccccc1,,Cc1ccccc1,,,,val
US20010051633A1,C/C=C/C(=O)OCC.c1ccc(CC2CCNCC2)cc1>>CCOC(=O)CC(C)N1CCC(Cc2ccccc2)CC1,,CC(C)O,,,,val
US20130274268A1,CS(=O)(=O)c1ccc(B(O)O)cc1.Cn1cc(Br)c2ncnc(OC3CCN(C(=O)OC(C)(C)C)CC3)c21>>Cn1cc(-c2ccc(S(C)(=O)=O)cc2)c2ncnc(OC3CCN(C(=O)OC(C)(C)C)CC3)c21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20110245353A1,CCOC(=O)c1c(C)nc2cccc(OCC3CCCC3)c2c1N>>Cc1nc2cccc(OCC3CCCC3)c2c(N)c1C(=O)O,,CCO,,[Na+].[OH-],,val
US20070213336A1,CCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)OC)cc2O)c1.CCCCI>>CCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)OC)cc2OCCCC)c1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150133400A1,FC1(F)CCC(Cn2ccc3ncc(Br)cc32)CC1.O=C1CCC(=O)N1I>>FC1(F)CCC(Cn2cc(I)c3ncc(Br)cc32)CC1,,CN(C)C=O,,,,val
US20140336106A1,C=C(C)C(=O)[C@H](CC1=CCCC1)NC(=O)OC(C)(C)C.O>>CC(C)(C)OC(=O)N[C@@H](CC1=CCCC1)C(=O)[C@@]1(C)CO1,,CN(C)C=O,,,,val
US20030149107A1,BrP(Br)Br.CCOC(=O)CCC(O)c1cccc(OCc2c(C)cccc2C)c1>>CCOC(=O)CCC(Br)c1cccc(OCc2c(C)cccc2C)c1,,C1COCCO1,,,,val
US20060128702A1,C1COCCN1.FC(F)(F)c1ccn(-c2cc(Cl)nc3ccccc23)n1>>FC(F)(F)c1ccn(-c2cc(N3CCOCC3)nc3ccccc23)n1,,CC(C)O,,,,val
US20060287522A1,COc1ccccc1B(O)O.O=C(NCc1cccnc1)c1ccc2n1Cc1ccccc1N(S(=O)(=O)c1ccc(Br)cc1)C2>>COc1ccccc1-c1ccc(S(=O)(=O)N2Cc3ccc(C(=O)NCc4cccnc4)n3Cc3ccccc32)cc1,,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US05599814,CO.Cc1cc(C)c2c(=O)oc(=O)[nH]c2c1>>COC(=O)c1c(C)cc(C)cc1N,,CO,,[Na+].[OH-],,val
US20160137636A1,COc1cc(-c2cccc(F)c2)ccc1C1c2ccc(S(=O)(=O)Oc3c(F)c(F)c(F)c(F)c3F)cc2CCN1C(C)=O.Nc1ccon1>>COc1cc(-c2cccc(F)c2)ccc1[C@@H]1c2ccc(S(=O)(=O)Nc3ccon3)cc2CCN1C(C)=O,,CO,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US04663373,C[Si](C)(C)N(C(=O)C(F)(F)F)[Si](C)(C)C.ON(Cc1ccccc1)Cc1ccccc1>>C[Si](C)(C)ON(Cc1ccccc1)Cc1ccccc1,,CC#N,,,,val
US20160096827A1,N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5CCOCC5)CC4)c(F)c3)n2)ccc1O[C@H]1CCNC[C@H]1F.O=C(O)CO>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5CCOCC5)CC4)c(F)c3)n2)ccc1O[C@H]1CCN(C(=O)CO)C[C@H]1F,,ClCCl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04894219,BrCc1ccccc1.OCc1ccc(O)c2ncccc12>>OCc1ccc(OCc2ccccc2)c2ncccc12,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US20090143444A1,CSc1ccccc1-c1cc(C=O)c[nH]1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ccccc1-c1cc(C=O)c[nH]1,,CCOC(C)=O,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20130217680A1,CCN(CC)C(=O)c1ccc(Br)cc1C.CON(C)C(=O)C(F)(F)F>>CCN(CC)C(=O)c1ccc(Br)cc1C(=O)C(F)(F)F,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20150133512A1,CC#CC(=O)OC.[N-]=[N+]=Nc1ccc(Br)cc1>>COC(=O)c1c(C)nnn1-c1ccc(Br)cc1,,Cc1ccccc1,,,,val
US20080035883A1,COC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.[NH4+]>>NC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,,C1CCOC1,,N,,val
US03953293,NC[C@H]1O[C@H](O[C@H]2[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H]3O)[C@@H](O)[C@H](N)C[C@@H]2N)[C@H](N)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](N)C[C@@H]2N)[C@H](N)[C@@H](O)[C@@H]1O,,CO,,Cl,,val
US20160176850A1,FC1(F)C[C@@H]1COc1nc(Cl)nc(N2CCC(c3n[nH]c4ncccc34)CC2)n1.N#CCC#N>>N#CC(C#N)c1nc(OC[C@H]2CC2(F)F)nc(N2CCC(c3n[nH]c4ncccc34)CC2)n1,,CC#N,CO,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20110152318A1,CC(NC(=O)c1csc(Cl)n1)c1cc(F)c(NS(C)(=O)=O)c(F)c1.OB(O)c1cccc(C(F)(F)F)c1>>CC(NC(=O)c1csc(-c2cccc(C(F)(F)F)c2)n1)c1cc(F)c(NS(C)(=O)=O)c(F)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05356885,C#CCN1CC[C@H](O[Si](C)(C)C(C)(C)C)C1=O.C=O.CCNCC>>CCN(CC)CC#CCN1CC[C@H](O[Si](C)(C)C(C)(C)C)C1=O,,CC(=O)O,,,,val
US20020193361A1,C=CC[C@H](C)[C@@H](CC(=O)C(C)(C)[C@@H](O)CC(=O)OC(C)(C)C)OC(=O)OCC(Cl)(Cl)Cl.CC[Si](Cl)(CC)CC>>C=CC[C@H](C)[C@@H](CC(=O)C(C)(C)[C@H](CC(=O)OC(C)(C)C)O[Si](CC)(CC)CC)OC(=O)OCC(Cl)(Cl)Cl,,CN(C)C=O,,O,c1c[nH]cn1,val
US20100256097A1,COc1ccc(C=N[C@@H](C)CO)cc1>>COc1ccc(CN[C@@H](C)CO)cc1,,CO,,[BH4-].[Na+],,val
US20080287458A1,CC(C)(O)CNS(=O)(=O)c1ccc(C=CC(=O)c2ccc(Cl)cc2Nc2ccccc2)cc1>>CC(C)(O)CNS(=O)(=O)c1ccc(CCC(=O)c2ccc(Cl)cc2Nc2ccccc2)cc1,,CCO,CCOC(C)=O,,,val
US20120010228A1,CC(C)(C)OC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCNCC3)C2=O)c1.O=C1COc2ccccc2N1CCCCl>>CC(C)(C)OC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCN(CCCN4C(=O)COc5ccccc54)CC3)C2=O)c1,,CCC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20100137305A1,Nc1ccc(I)cc1F.O=C(Cl)C1CC1>>O=C(Nc1ccc(I)cc1F)C1CC1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US06156758,CC(C)(C)OC(=O)c1ccc(NC2CCNCC2)c([N+](=O)[O-])c1.COc1cc2nc(Cl)nc(N)c2cc1OC>>COc1cc2nc(N3CCC(Nc4ccc(C(=O)OC(C)(C)C)cc4[N+](=O)[O-])CC3)nc(N)c2cc1OC,,CCCCCO,,,,val
US20140371269A1,CC(C)(C)C1CCN(Cc2ccc([C@H](NS(C)(=O)=O)C(F)(F)F)cc2)CC1.O=P(O)(O)O>>CC(C)(C)C1CCN(Cc2ccc([C@H](NS(C)(=O)=O)C(F)(F)F)cc2)CC1.O=P(O)(O)O,,CC(C)=O,,,,val
US20120157425A1,Nc1cnc(Cl)nc1O.O=C(O)c1ccncc1>>O=C(Nc1cnc(Cl)nc1O)c1ccncc1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20090156610A1,C=C(N=Cc1cc(Cl)ccc1OC1CCC2(CC1)OCCO2)O[Si](C)(C)C.CC(C)(C)OC(=O)N1C(=O)/C(=C\c2cccc(Cl)c2)c2ccc(Cl)cc21>>O=C1CC(c2cccc(Cl)c2)C2(C(=O)Nc3cc(Cl)ccc32)C(c2cc(Cl)ccc2OC2CCC3(CC2)OCCO3)N1,,Cc1ccccc1,,,,val
US20120094917A1,COC(=O)C1CNC2CCN(C(=O)C(NC(=O)OC(C)(C)C)C3CCCCC3)C21.CS(=O)(=O)Cl>>COC(=O)C1CN(S(C)(=O)=O)C2CCN(C(=O)C(NC(=O)OC(C)(C)C)C3CCCCC3)C12,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090156572A1,CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(S(=O)(=O)C2CCN(C(=O)OCc3ccccc3)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1>>CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(S(=O)(=O)C2CCNCC2)C[C@H]1c1ccc(Cl)c(Cl)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20020156069A1,COc1ccc(CNC(=O)c2ccc3c(c2)S(=O)(=O)NC(=O)N3C)cc1.O=[N+]([O-])c1ccc(CBr)cc1>>COc1ccc(CNC(=O)c2ccc3c(c2)S(=O)(=O)N(Cc2ccc([N+](=O)[O-])cc2)C(=O)N3C)cc1,,CN(C)C=O,Cl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050070549A1,COC(=O)C1(C)CN(C(=O)OC(C)(C)C)CCC1=O.Clc1ccc([Mg]Br)cc1>>COC(=O)C1(C)CN(C(=O)OC(C)(C)C)CCC1(O)c1ccc(Cl)cc1,,C1CCOC1,,,,val
US20160002177A1,COc1cc(Br)c(C(F)(F)F)c2c(=O)[nH]cnc12>>O=c1[nH]cnc2c(O)cc(Br)c(C(F)(F)F)c12,,ClCCl,,BrB(Br)Br,,val
US20100267697A1,CCI.CCOC(=O)c1ccc(NC2CC2)nc1>>CCOC(=O)c1ccc(N(CC)C2CC2)nc1,,C1CCOC1,,CN(C)C=O,[H-].[Na+],val
US20130150326A1,CC(=O)COc1cccc(Br)c1.NNc1cccc(Cl)c1>>Cc1[nH]c2cc(Cl)ccc2c1Oc1cccc(Br)c1,,CC#N,,Cl,,val
US20090098086A1,NNC1CCC2(CC1)OCCO2.O=Cc1c(Cl)nc(Cl)nc1Cl>>Clc1nc(Cl)c2cnn(C3CCC4(CC3)OCCO4)c2n1,,O,,CCN(CC)CC,CCO,val
US20090181942A1,COc1cccc(C(=O)c2c(N)cccc2Cl)c1OC>>COc1cccc(C(O)c2c(N)cccc2Cl)c1OC,,CO,,[BH4-].[Na+],,val
US20120157439A1,COc1ccc(CCCCS(=O)(=O)Nc2ccc(F)c(NC(=O)c3c[nH]c4c(Cl)ncnc34)c2F)cc1.N>>CCCS(=O)(=O)Nc1ccc(F)c(NC(=O)c2c[nH]c3c(N)ncnc23)c1F,,CC(C)O,,,,val
US06034127,CC(C)(C)OC(=O)N1CCC(CO)CC1.Cc1cc(O)cc(OS(=O)(=O)c2cccc(Cl)c2)c1>>Cc1cc(OCC2CCN(C(=O)OC(C)(C)C)CC2)cc(OS(=O)(=O)c2cccc(Cl)c2)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US08828401B2,CC[C@H](C)[C@@H]([C@@H](CC(=O)O)OC)N(C)C(=O)[C@@H](NC(=O)C(C)(C)N(C)C(=O)OCC1c2ccccc2-c2ccccc21)C(C)C.O=C(CC(F)(F)F)Oc1c(F)c(F)c(F)c(F)c1F>>CC[C@H](C)[C@@H]([C@@H](CC(=O)Oc1c(F)c(F)c(F)c(F)c1F)OC)N(C)C(=O)[C@@H](NC(=O)C(C)(C)N(C)C(=O)OCC1c2ccccc2-c2ccccc21)C(C)C,,ClCCl,,c1ccncc1,,val
US20120214809A1,CI.CN1CCCC1CCN(c1ccccc1)C1Cc2ccccc2C1>>C[N+]1(C)CCCC1CCN(c1ccccc1)C1Cc2ccccc2C1.[I-],,ClCCCl,,,,val
US20050070609A1,COC(=O)C1CCC2(CCN(C(=O)OC(C)(C)C)CC2)C1=O.NN>>CC(C)(C)OC(=O)N1CCC2(CCc3c2[nH][nH]c3=O)CC1,,Cc1ccccc1,,,,val
US20130210831A1,CN(c1ccc(N)c(N)n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1.O=C(n1ccnc1)n1ccnc1>>CN(c1ccc2[nH]c(=O)[nH]c2n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1,,C1CCOC1,,,,val
US05254575,BrBr.COc1cc(C(C)=O)cc(Cl)c1OC>>COc1cc(C(=O)CBr)cc(Cl)c1OC,,ClC(Cl)Cl,,O=C([O-])O.[K+],,val
US20030144282A1,COC(=O)c1ccc(S(=O)(=O)CCc2c(CCNS(=O)(=O)Cc3ccccc3F)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1>>O=C(O)c1ccc(S(=O)(=O)CCc2c(CCNS(=O)(=O)Cc3ccccc3F)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1,,CO,,C1CCOC1,[Na+].[OH-],val
US05792766,CC(=O)Cl.COc1ccc(-c2ncc3n2CNc2ccccc2-3)cc1>>COc1ccc(-c2ncc3n2CN(C(C)=O)c2ccccc2-3)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20110092505A1,BrBr.CC(C)(C)OC(=O)N1CCN(c2cccc(-c3ccnc(Cl)c3)n2)CC1>>CC(C)(C)OC(=O)N1CCN(c2ccc(Br)c(-c3ccnc(Cl)c3)n2)CC1,,ClCCl,,,,val
US20020022628A1,O=C(CCc1cncc(Cl)c1)CS(=O)(=O)N1CCN(c2ccc(Cl)cc2)CC1>>O=S(=O)(CC(O)CCc1cncc(Cl)c1)N1CCN(c2ccc(Cl)cc2)CC1,,CO,ClCCl,[BH4-].[Na+],,val
US05599816,CC(C)(C)OC(=O)N1CCC[C@H]1[C@H](CCO)C[N+](=O)[O-]>>CC(C)(C)OC(=O)N1CCC[C@H]1[C@@H]1CCNC1,[Pd],CO,,,,val
US20130336920A1,CCN(CC)CCN(C)Cc1cccc(C(=O)O)c1.Nc1ccc(Cl)cc1-c1cc(NCc2cccc(C(F)(F)F)c2)ncn1>>CCN(CC)CCN(C)Cc1cccc(C(=O)Nc2ccc(Cl)cc2-c2cc(NCc3cccc(C(F)(F)F)c3)ncn2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070232583A1,CCCC(=O)OC(=O)CCC.Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(N)(=O)=O)c3)n2)n1>>CCCC(=O)NS(=O)(=O)c1cccc(-c2cccc(-c3cc(-c4ccc(C(F)(F)F)cc4)cc(C)n3)n2)c1,,CCCCCCC,,,,val
US20070275952A1,Fc1nc(F)c(F)c(F)c1F.NCc1ccccc1N1CCN(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1>>O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(c2ccccc2CNc2c(F)c(F)nc(F)c2F)CC1,,CC#N,CO,CCN(CC)CC,,val
US20060084663A1,COC(=O)CCc1ccc(OCCc2nc(-c3ccc(Cl)nc3)oc2C)cc1C.OB(O)c1ccccc1>>COC(=O)CCc1ccc(OCCc2nc(-c3ccc(-c4ccccc4)nc3)oc2C)cc1C,,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20060025472A1,Cc1nc(N)ccc1Cl.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1c(Cl)ccc(N)[n+]1[O-].Cl,,ClCCl,,O=S([O-])O.[Na+],,val
US20140343032A1,CC(C)(C)OC(=O)N1C(CO)CCC1(CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCC2CCC(CO[Si](C)(C)C(C)(C)C)(CO[Si](C)(C)C(C)(C)C)N2C(=O)OC(C)(C)C)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20050182052A1,C[C@@H]1CN(Cc2ccccc2)C[C@H]1C(=O)O.NC1CC1>>C[C@@H]1CN(Cc2ccccc2)C[C@H]1C(=O)NC1CC1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US06462036B1,Cl.ClCCCl.NCCCn1ccnc1.O=Cc1ccc(-c2n[nH]c3c2sc2ccccc23)cc1>>Cl.Cl.Cl.c1ccc2c(c1)sc1c(-c3ccc(CNCCCn4ccnc4)cc3)n[nH]c12,Cl,CCO,,CC(=O)O,O=C([O-])O.[Na+],val
US05883134,CCSC(=C[N+](=O)[O-])CC.OO>>CCC(=C[N+](=O)[O-])S(=O)CC,,O=CO,,,,val
US20130137679A1,CC(C)(C)OC(=O)N1CCCN(c2cccc(Cl)c2Cl)CC1.Cl>>Cl.Clc1cccc(N2CCCNCC2)c1Cl,,CCOC(C)=O,,,,val
US04508921,N[C@@H](Cc1ccccc1)C(=O)O.O=Cc1ccc(Cl)cc1Cl.[Na+]>>O=C([O-])C(Cc1ccccc1)N=Cc1ccc(Cl)cc1Cl.[Na+],,CCO,,O,,val
US20160122327A1,CO/N=C(\C)c1ccc(O)cc1.COC(=O)NNc1cc(CO)ccc1Cl>>CO/N=C(\C)c1ccc(OCc2ccc(Cl)c(NNC(=O)OC)c2)cc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05041573,CCOC(=O)CBr.N[C@H](c1ccccc1)[C@@H](O)c1ccccc1>>CCOC(=O)CN[C@H](c1ccccc1)[C@@H](O)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20130035354A1,COc1ccc(S(=O)(=O)Cl)cc1.N#Cc1ccc(-c2cncc(N)c2)cc1Cl>>COc1ccc(S(=O)(=O)Nc2cncc(-c3ccc(C#N)c(Cl)c3)c2)cc1,,c1ccncc1,,,,val
US20070082912A1,CC(=O)CCC(=O)c1cc(Br)ccc1OCc1ccc(F)cc1.COC(=O)c1cc(N)cc(C(F)(F)F)c1>>COC(=O)c1cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2)cc(C(F)(F)F)c1,,CCOC(C)=O,CN1CCCC1=O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20130203727A1,CC(CC(=O)O)Cc1cccc(Br)c1>>CC1CC(=O)c2ccc(Br)cc2C1,,ClC(Cl)Cl,ClCCl,O=S(=O)(O)C(F)(F)F,,val
US05521271,CCC(N)CC.O=C1c2ccccc2C(=O)c2c(Cl)cccc21>>CCC(CC)Nc1cccc2c1C(=O)c1ccccc1C2=O,[Cu],O,,CC(=O)[O-].[K+],,val
US20120094972A1,CSc1ccccc1B(O)O.Cc1c(Cl)nc2cc(F)cc(F)c2c1Cl>>CSc1ccccc1-c1nc2cc(F)cc(F)c2c(Cl)c1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CC#N,O=C([O-])[O-].[Na+].[Na+],val
US20110306591A1,CCOC(=S)[S-].Nc1cc(F)ccc1F>>Fc1ccc2sc(S)nc2c1,,CN(C)C=O,,Cl,,val
US20150183802A1,CC1(C)OC(=O)C(=CNc2ccc(F)c(Br)c2)C(=O)O1>>Oc1ccnc2cc(Br)c(F)cc12,,c1ccc(Oc2ccccc2)cc1,,,,val
US05141994,C=CC.C=CC1CCCCC1>>C=CC.C=CC1CCCCC1,,CCCCCCC,,[H][H],,val
US20100029710A1,Cc1ccnc([N+](=O)[O-])c1N>>Cc1ccnc(N)c1N,[Ni],CO,,,,val
US20110201555A1,CCO.Cc1noc(C)c1-c1c(C=O)c2ccccc2n1-c1ccc(O)cc1.NO>>CON=Cc1c(-c2c(C)noc2C)n(-c2ccc(O)cc2)c2ccccc12,,CCO,,c1ccncc1,,val
US20070066617A1,CC(=O)OCc1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1F>>OCc1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1F,,CCO,O,Cl,[Na+].[OH-],val
US20160214935A1,O=C(Br)CBr.O=C1NCC2(CCNCC2)O1>>O=C1NCC2(CCN(C(=O)CBr)CC2)O1,,ClC(Cl)Cl,O,c1ccncc1,,val
US20080318963A1,CCOC(=O)Nc1nc2cc(Cl)c(Cl)cc2nc1OC.COc1cccc(N2CCNCC2)c1>>COc1cccc(N2CCN(C(=O)Nc3nc4cc(Cl)c(Cl)cc4nc3OC)CC2)c1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20160235721A1,COC(=O)c1cc2snnc2c(F)c1Nc1ccc(Br)cc1Cl>>O=C(O)c1cc2snnc2c(F)c1Nc1ccc(Br)cc1Cl,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US20070225372A1,COc1ccc(Br)c2c1CN(C(=O)OC(C)(C)C)[C@@H](CO)C2>>COc1ccc(Br)c2c1CN(C(=O)OC(C)(C)C)[C@@H](C=O)C2,,CS(C)=O,,CCN(CC)CC,,val
US04166735,CC(C)Br.Cc1ccccc1O>>Cc1ccccc1OC(C)C,,CS(C)=O,,[Na+].[OH-],,val
US20120232135A1,OC/C=C/c1ccc(OCc2ccccc2)c(OCc2ccccc2)c1.Oc1cc(OCc2ccccc2)cc(OCc2ccccc2)c1Cc1ccccc1>>Oc1c(C/C=C/c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)c(OCc2ccccc2)cc(OCc2ccccc2)c1Cc1ccccc1,,ClCCl,,,,val
US20040053908A1,COc1cc2nccc(OCCCN)c2cc1OC.O=C=Nc1ccc(F)cc1>>COc1cc2nccc(OCCCNC(=O)Nc3ccc(F)cc3)c2cc1OC,,CCOC(C)=O,,,,val
US20120322837A1,CC(C)(C)CC1CC(C=C(Br)Br)C1.COCNC(=O)C(CCCOCc1ccccc1)CC(=O)OC(C)(C)C>>CC(C)(C)CC1CC(C#CC(=O)C(CCCOCc2ccccc2)CC(=O)OC(C)(C)C)C1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US05641784,CCCn1c(=O)c2[nH]c(C3CCC(C(=O)O)C3)nc2n(CCC)c1=O.N#CCCCCCN>>CCCn1c(=O)c2[nH]c(C3CCC(C(=O)NCCCCCC#N)C3)nc2n(CCC)c1=O,,C1CCOC1,ClCCl,O=C(n1ccnc1)n1ccnc1,,val
US20060235029A1,Cc1ccc(NC(=O)c2ccsc2)cc1-c1nc(NC2CC(C)(C)NC(C)(C)C2)nc2c1ccc(=O)n2-c1c(F)cccc1F.Cl>>Cc1ccc(NC(=O)c2ccsc2)cc1-c1nc(NC2CC(C)(C)NC(C)(C)C2)nc2c1ccc(=O)n2-c1c(F)cccc1F.Cl,,CC(C)O,,,,val
US06110937,COc1cccc(B(O)O)c1.Cc1cc(Br)cc(C)c1OCC1CCCN(C)C1>>COc1cccc(-c2cc(C)c(OCC3CCCN(C)C3)c(C)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20150166575A1,CC(C)(C)OC(=O)N1CCCN(c2ccc(C=O)c(O)n2)CC1.CCOC(=O)CC(C)=O>>CC(=O)c1cc2ccc(N3CCCN(C(=O)OC(C)(C)C)CC3)nc2oc1=O,,CCO,,C1CCNCC1,CC(=O)O,val
US20080280887A1,CCOC(=O)c1ccc(N2CCNCC2)cc1.Nc1c(Cl)cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc1C(F)(F)F>>CCOC(=O)c1ccc(N2CCN(C(=O)[C@@H](Cc3cc(Cl)c(N)c(C(F)(F)F)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)cc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US03939266,CS(=O)(=O)CC(=O)O.NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=CCS[C@H]12>>CS(=O)(=O)CC(=O)NC1C(=O)N2C(C(=O)O)=CCS[C@H]12,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100004331A1,CCOC(=O)Cc1ccc(OC)c(Oc2ccc(NC(=O)OCCCl)cc2CSCC(F)(F)F)c1>>COc1ccc(CC(=O)O)cc1Oc1ccc(N2CCOC2=O)cc1CSCC(F)(F)F,,CCO,,C,C[O-].[Na+],val
US20130116245A1,CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])nc2)C(C)(C)C1>>CC(C)(C)OC(=O)N1CCN(c2ccc(N)nc2)C(C)(C)C1,[Pd],CO,,,,val
US04639441,COCC(=O)Cl.COS(=O)(=O)F.O=C(CNC=S)OCc1ccc([N+](=O)[O-])cc1>>COC1C(=O)N(CC(=O)OCc2ccc([N+](=O)[O-])cc2)C1SC,,CCN(CC)CC,,,,val
US04699647,NNC(=O)c1ccccc1SCc1ccccc1.O=C(Cl)OC(Cl)(Cl)Cl>>O=c1[nH]nc(-c2ccccc2SCc2ccccc2)o1,,C1COCCO1,,,,val
US20150291554A1,COC(=O)c1ccc(Oc2ccc(Cl)cc2)cc1>>O=C(O)c1ccc(Oc2ccc(Cl)cc2)cc1,,CO,O,[Na+].[OH-],,val
US04105773,CC(=O)Nc1csc(Br)n1.COS(=O)(=O)c1ccc(C)cc1>>CC(=O)N(C)c1csc(Br)n1,,CC#N,,[H-].[Na+],,val
US04281019,C=CCNc1ccc(CC(=O)O)cc1.CI>>C=CCNc1ccc(CC(=O)OC)cc1,,CN(C)P(=O)(N(C)C)N(C)C,,[H-].[Na+],,val
US20110136780A1,CCC1(N2Cc3c[nH]c4nccc(c34)C2=O)CCNCC1.N#CCC(=O)ON1C(=O)CCC1=O>>CCC1(N2Cc3c[nH]c4nccc(c34)C2=O)CCN(C(=O)CC#N)CC1,,CCO,,CCN(CC)CC,,val
US20110166133A1,N#Cc1cccc(Nc2nc(Cl)ccc2N)c1.N=CN>>N#Cc1cccc(-n2cnc3ccc(Cl)nc32)c1,,CCO,,CC(=O)O,,val
US08937077B2,COC(=O)c1ccc(CN)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.c1nc(N2CC[C@H]3NCCC[C@H]32)c2cc[nH]c2n1>>COC(=O)c1ccc(CNC(=O)N2CCC[C@@H]3[C@H]2CCN3c2ncnc3[nH]ccc23)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110034451A1,CCN.COC(=O)c1nn2c(N)nnc2c(C)c1C>>CCNC(=O)c1nn2c(N)nnc2c(C)c1C,,CO,,Cl,,val
US20120208833A1,CSCCN.O=Cc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1>>CSCCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1,,CO,ClCCl,CCN(CC)CC,Cl,val
US20030125317A1,COC(=O)C=Cc1ccc(OC)cc1CN(CC(F)(F)F)C(=O)OC(C)(C)C>>COC(=O)CCc1ccc(OC)cc1CN(CC(F)(F)F)C(=O)OC(C)(C)C,[Pd],CO,,,,val
US20050187272A1,N[C@@H](CS)C(=O)O.O=Cc1ccc([N+](=O)[O-])cc1>>O=C(O)[C@@H]1CSC(c2ccc([N+](=O)[O-])cc2)N1,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US04017633,CC(=O)c1c(O)oc(=O)c(C(C)=O)c1O.Nc1ccccc1>>CC(=O)C1=C(O)C(=C(C)Nc2ccccc2)C(=O)OC1=O,,c1ccccc1,,,,val
US20090124625A1,BrBr.OCCCC#Cc1ccccn1>>BrCCCC#Cc1ccccn1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06887881B1,CC(C)OC(=O)N1CC2CC(CN(CC(N=[N+]=[N-])c3ccc(C#N)cc3)C2)C1>>CC(C)OC(=O)N1CC2CC(CN(CC(N)c3ccc(C#N)cc3)C2)C1,[Pd],CCO,,,,val
US20130040930A1,COc1ccc(CN2CC(C)NC2=O)cc1.O=C(Cl)c1ccccc1>>COc1ccc(CN2CC(C)N(C(=O)c3ccccc3)C2=O)cc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US05656629,CC(=O)n1ccnc1.CCc1[nH]n(C2CCCC2)c2nc(COS(C)(=O)=O)nc(=O)c1-2>>CCc1[nH]n(C2CCCC2)c2nc(Cc3ncc[nH]3)nc(=O)c1-2,,CC#N,,O=C([O-])O.[Na+],,val
US20050209274A1,O=C(NC1CCNCC1)c1cc(=O)c2ccc(F)cc2o1.O=Cc1ccc2occc2c1>>O=C(NC1CCN(Cc2ccc3occc3c2)CC1)c1cc(=O)c2ccc(F)cc2o1,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04894386,NCC1CCCC1.O=C(O)Cc1ccc2cc[nH]c2c1>>O=C(Cc1ccc2cc[nH]c2c1)NCC1CCCC1,,CN(C)C=O,ClCCl,O=C(n1ccnc1)n1ccnc1,,val
US20100331326A1,Cc1ccc(S(=O)(=O)n2cc(N3CCN(c4cnccc4C)C3=O)c3ccccc32)cc1>>Cc1ccncc1N1CCN(c2c[nH]c3ccccc23)C1=O,,CCO,ClC(Cl)Cl,CO,[Na+].[OH-],val
US20070167488A1,Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1.O=S(=O)(Cl)Cl>>Cc1[nH]c(C=C2C(=O)Nc3ccccc32)c(C)c1Cl,,ClCCl,,,,val
US04065572,CCOC(=O)C(Cc1ccc(C#N)cc1)(NC(C)=O)C(=O)OCC.S>>CCOC(=O)C(Cc1ccc(C(N)=S)cc1)(NC(C)=O)C(=O)OCC,,c1ccncc1,,CCN(CC)CC,,val
US20120171616A1,C=C(C)C(=O)OCCC(F)(F)C(F)(F)S(=O)(=O)[O-].c1ccc(-c2cccc3[sH+]c4ccccc4c23)cc1>>C=C(C)C(=O)OCCC(F)(F)C(F)(F)S(=O)(=O)[O-].c1ccc(-c2cccc3[sH+]c4ccccc4c23)cc1,,ClCCl,,[Br-].[K+],,val
US20140364413A1,CCOC(=O)CC1(c2ccc(O)cc2)COC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)CC1(c2ccc(OS(=O)(=O)C(F)(F)F)cc2)COC1,,ClCCl,,,,val
US20080207666A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1(C)CC(N)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Br)cc3Cl)nc2O1>>CC(C)(C)OC(=O)NC1CC(C)(C)Oc2nc(-c3ccc(Br)cc3Cl)c(-c3ccc(Cl)cc3)cc21,,ClCCl,,CCN(CC)CC,,val
US20080319080A1,C#CCOc1ccc(C(=O)O)cc1OC.O=S(Cl)Cl>>C#CCOc1ccc(C(=O)Cl)cc1OC,CN(C)C=O,Cc1ccccc1,,,,val
US20070265286A1,COc1cc2c(Nc3c(F)cc(Cl)cc3F)ncnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1>>COc1cc2c(Nc3c(F)cc(Cl)cc3F)ncnc2cc1OCC1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090275606A1,Cc1c(Nc2ccc(I)cc2F)c(C(=O)NOCCOC(C)(C)C)c2n(c1=O)CCC2>>Cc1c(Nc2ccc(I)cc2F)c(C(=O)NOCCO)c2n(c1=O)CCC2,,ClCCl,,CO,O=C(O)C(F)(F)F,val
US20110184029A1,CC(=O)OCc1cc(C#N)cc(C#N)c1>>N#Cc1cc(C#N)cc(CO)c1,,CO,,[NH4+].[OH-],,val
US20040248941A1,CC(Cl)OC(=O)c1ccccc1.Cc1c(OCC(F)(F)F)ccnc1CSc1nc2ccccc2[nH]1>>Cc1c(OCC(F)(F)F)ccnc1CSc1nc2ccccc2n1C(C)OC(=O)c1ccccc1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20090042876A1,CCC(=O)[O-].O=c1[nH]c2ccccc2c2cc[nH]c12>>O=C(O)c1c[nH]c2c(=O)[nH]c3ccccc3c12,,CCO,O,[Li+].[OH-],,val
US05292732,CC(=O)NCCN.COc1ccc(C(=O)CCC2OCCO2)cc1OC>>COc1ccc(-c2cccn2CCNC(C)=O)cc1OC,,CC(=O)O,,,,val
US04416890,NS(=O)(=O)c1nc2ccc(O)cc2s1.O=C(Cl)C=Cc1ccccc1>>NS(=O)(=O)c1nc2ccc(OC(=O)C=Cc3ccccc3)cc2s1,CN(C)c1ccncc1,CN(C)C=O,,CCN(CC)CC,Cl,val
US05234931,CN1C2CCC1CC(c1n[nH]c3cc(F)ccc13)C2.N#CBr>>N#CN1C2CCC1CC(c1n[nH]c3cc(F)ccc13)C2,,C1CCOC1,O,O=C([O-])[O-].[K+].[K+],,val
US20160152543A1,CCOC(=O)C(OC(C)(C)C)c1c(OCc2ccccc2)c(C2CC2)cc2ncccc12>>CCOC(=O)C(OC(C)(C)C)c1c(O)c(C2CC2)cc2ncccc12,[Pd],CCO,ClCCl,,,val
US20010018423A1,CCS(=O)(=O)N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1>>CCS(=O)(=O)N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O,[Pd],CCOC(C)=O,,,,val
US20050096343A1,CC(=O)NC[C@H]1CN(c2ccc(NC3CCN(C(=O)OCc4ccccc4)CC3)c(F)c2)C(=O)O1>>CC(=O)NC[C@H]1CN(c2ccc(NC3CCNCC3)c(F)c2)C(=O)O1,[Pd],ClCCl,O=C(O)C(F)(F)F,,,val
US20090176786A1,CI.CN(C(=O)NC(=O)c1c(F)cccc1F)c1ccc(SC(F)(F)C(F)(F)F)cc1F>>CN(C(=O)c1c(F)cccc1F)C(=O)N(C)c1ccc(SC(F)(F)C(F)(F)F)cc1F,,CCOC(C)=O,,[H-].[Na+],[Cl-].[NH4+],val
US20160264567A1,CCOC(=O)c1cc(-c2cnc(C(F)(F)F)nc2)cnc1C(F)(F)F>>OCc1cc(-c2cnc(C(F)(F)F)nc2)cnc1C(F)(F)F,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US20130023568A1,CC(=O)O.Nc1ccc2[nH]ncc2c1>>CC(=O)Nc1ccc2[nH]ncc2c1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20020193596A1,COC(=O)[C@H](CCSC)NC(=O)c1ccc(C(=O)[C@H](Cc2c[nH]cn2)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1-c1ccccc1>>COC(=O)[C@H](CCSC)NC(=O)c1ccc(C(=O)[C@@H](N)Cc2c[nH]cn2)cc1-c1ccccc1,,C1COCCO1,Cl,CCOCC,,val
US20080139539A1,COc1ccc2nccc(N3CCN(CCN)C(=O)C3)c2n1.O=Cc1ccc2c(n1)NC(=O)CS2>>COc1ccc2nccc(N3CCN(CCNCc4ccc5c(n4)NC(=O)CS5)C(=O)C3)c2n1,,CCO,ClCCl,O=C([O-])O.[Na+],,val
US06884868B1,CC(=O)SC1CCN(c2ccc([N+](=O)[O-])cc2)CC1.CCCI>>CCCSC1CCN(c2ccc(N)cc2)CC1,,C1CCOC1,CO,C[O-].[Na+],,val
US20070265284A1,CC(C)=CCn1c(Br)nc2c1c(=O)[nH]c(=O)n2C.O=C(CBr)c1ccccc1>>CC(C)=CCn1c(Br)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05574042,BrCc1ccccc1.CNc1cc(Cl)cc(Cl)c1>>CN(Cc1ccccc1)c1cc(Cl)cc(Cl)c1,,CC#N,,CCN(CC)CC,,val
US20140323435A1,CC(C)(C)OC(=O)NCCN.Clc1nc(Cl)c2c3c(sc2n1)CCCC3>>CC(C)(C)OC(=O)NCCNc1nc(Cl)nc2sc3c(c12)CCCC3,,CC(=O)N(C)C,,CCN(CC)CC,,val
US20110213157A1,CC12CC=Cc3cccc(c31)CCC2>>CC12CCCc3cccc(c31)CCC2,[Pd],CCO,,,,val
US20020013310A1,Cc1ccc(C#N)c(N)c1.O=Cc1ccccc1>>Cc1ccc(C#N)c(N=Cc2ccccc2)c1,,CCCCCCC,,CCOC(C)=O,,val
US20160130237A1,CC(C)N1CCN(C(=O)OC(C)(C)C)CC1>>CC(C)N1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US08951997B2,CC(C)(C)OC(=O)N[C@H]1CCN(S(=O)(=O)c2ccc3cnccc3c2)C1.CCCCI>>CCCCN(C(=O)OC(C)(C)C)[C@H]1CCN(S(=O)(=O)c2ccc3cnccc3c2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20120220576A1,C1COCCN1.CCN(C(C)C)C(C)C.CCOC(C)=O.Clc1nc(Cl)c2cc[nH]c2n1>>c1cc2c(N3CCOCC3)nc(N3CCOCC3)nc2[nH]1,,CCOC(C)=O,,CN1CCCC1=O,,val
US05244911,C1CCOC1.CCCN(CCC)C1Cc2c(C#N)ccc3c2C(C1)CN3C(c1ccccc1)(c1ccccc1)c1ccccc1.C[Mg]Br>>CCCN(CCC)[C@H]1Cc2c(C(C)=O)ccc3c2[C@@H](CN3)C1,,CCOCC,,[Cl-].[NH4+],,val
US20140038957A1,Cc1c[nH]c2ncnc(N3CCC(N)CC3)c12.Cc1ccccc1C(=O)Cl>>Cc1ccccc1C(=O)NC1CCN(c2ncnc3[nH]cc(C)c23)CC1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US04001227,Nc1c(Cl)cccc1CO.S=C=S>>S=C1Nc2c(Cl)cccc2CS1,,CCO,,Cl,[K+].[OH-],val
US20140005172A1,CC(C)(C)OC(=O)N1CCOc2ccc(B(O)O)cc2C1.Nc1ncc(Br)cc1S(N)(=O)=O>>CC(C)(C)OC(=O)N1CCOc2ccc(-c3cnc(N)c(S(N)(=O)=O)c3)cc2C1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20080119518A1,CNC1CCN(C(=O)OC(C)(C)C)CC1.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC(NCC(=O)OCc2ccccc2)CC1,,ClC(Cl)Cl,O,CCN(CC)CC,ClCCl,val
US20080113923A1,CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)OCC(CO)(CO)CO.O>>CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)OCC(CO)(CO)CO.O,,O,,,,val
US20150094296A1,CC(C)(CO)n1cc(N)cn1.N#C[C@@]1(C2CC2)CCN(c2ccnc(Cl)n2)C1=O>>CC(C)(CO)n1cc(Nc2nccc(N3CC[C@@](C#N)(C4CC4)C3=O)n2)cn1,,CCO,,CC(=O)O,,val
US20130131042A1,COc1ccc2c(C=O)c[nH]c2c1.OB(O)C1CC1>>COc1ccc2c(C=O)cn(C3CC3)c2c1,,ClCCl,,,,val
US20080207654A1,CCCc1nc(CC)c(CN2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCc1nc(CC)c(CN2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,O,,CS(C)=O,[Cl-].[Na+],val
US20150210688A1,COC(=O)Cl.Cc1ccc(C(=O)N2CC(c3ccc(C#N)cc3)C2)cc1-c1[nH]c(C2CNC2)nc1C>>COC(=O)N1CC(c2nc(C)c(-c3cc(C(=O)N4CC(c5ccc(C#N)cc5)C4)ccc3C)[nH]2)C1,,CC#N,CN(C)C=O,CCN(CC)CC,O,val
US20110189118A1,Cc1cc(=O)nc(NC(=O)NCCCCN)[nH]1.Clc1nc(Cl)nc(Cl)n1>>Cc1cc(=O)nc(NC(=O)NCCCCNc2nc(Cl)nc(Cl)n2)[nH]1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20040127536A1,COCC(=O)Cl.Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4nnn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1>>COCC(=O)Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4nnn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1,,C1CCOC1,,CCN(CC)CC,,val
US20070099936A1,CCOC(=O)CBr.NC1c2ccccc2C(=O)N1Cc1ccccc1>>CCOC(C)=O.NC1c2ccccc2C(=O)N1Cc1ccccc1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20150315198A1,Clc1nccc2[nH]ncc12.O=c1ccccn1Cc1ccc(CBr)cc1>>O=c1ccccn1Cc1ccc(Cn2cc3c(Cl)nccc3n2)cc1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20080319074A1,CCCCCCC(=COC)c1ccc(C(=O)OC)cc1>>CCCCCCC(C=O)c1ccc(C(=O)OC)cc1,,C1CCOC1,,Cl,,val
US04182711,COCCOCC(=O)Cl.S>>COCCOCC(O)=S,,ClCCl,,CCN(CC)CC,,val
US20080058309A1,Nc1c(Cl)ccc2nc(N3CCOCC3)ccc12.O=C(Cl)CCl>>O=C(CCl)Nc1c(Cl)ccc2nc(N3CCOCC3)ccc12,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20030149016A1,CC(C)(C)[Si](C)(C)Cl.NS(=O)(=O)c1ncn2ccsc12>>CC(C)(C)[Si](C)(C)NS(=O)(=O)c1ncn2ccsc12,,CN(C)C=O,,CCN(CC)CC,CCOC(C)=O,val
US05217961,Nc1ccc(F)cc1.O=C(CCl)Nc1ccccc1C(=O)O>>O=C(CNc1ccc(F)cc1)Nc1ccccc1C(=O)O,,CN(C)C=O,,,,val
US04638068,CC(C)C(C)(NC(=O)c1ccc2ccccc2n1)C(N)=O>>CC(C)C1(C)NC(c2ccc3ccccc3n2)=NC1=O,,Cc1ccccc1C,,O,[H-].[Na+],val
US20130079346A1,COC(=O)c1cc(-c2nc(-c3ccc(F)c(Cl)c3)cs2)ccc1-c1ccccc1[N+](=O)[O-]>>O=C(O)c1cc(-c2nc(-c3ccc(F)c(Cl)c3)cs2)ccc1-c1ccccc1[N+](=O)[O-],,C1COCCO1,O,[Na+].[OH-],,val
US06313122B1,CC(C)(C)c1ccc(C(=O)Cl)cc1.Nc1ccccc1C(=O)O>>CC(C)(C)c1ccc(-c2nc3ccccc3c(=O)o2)cc1,,c1ccncc1,,Cl,,val
US20090324581A1,CC(C)(C)OC(=O)CCN(CC(=O)N1CCc2cc(O)ccc21)C(=O)OC(C)(C)C.FC(F)(F)c1ccc(CBr)c(C(F)(F)F)c1>>CC(C)(C)OC(=O)CCN(CC(=O)N1CCc2cc(OCc3ccc(C(F)(F)F)cc3C(F)(F)F)ccc21)C(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120122817A1,CCn1cc(C(=O)OCCO)c(=O)c2cc(Br)cnc21.O=P(O)(OCc1ccccc1)OCc1ccccc1>>CCn1cc(C(=O)OCCOP(=O)(OCc2ccccc2)OCc2ccccc2)c(=O)c2cc(Br)cnc21,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040162314A1,CC(C)c1cc(-c2cccc(C(O)c3ccc(Cl)cc3)c2)c2ncccc2c1.O=S(Cl)Cl>>CC(C)c1cc(-c2cccc(C(Cl)c3ccc(Cl)cc3)c2)c2ncccc2c1,,c1ccccc1,,,,val
US20140275092A1,CC(C)(C)O[K].CCOC(=O)CC(=O)CCCOC>>CCOC(=O)C(CC)C(=O)CCCOC,,C1CCOC1,,,,val
US20140357664A1,C[C@@H]1N[C@@H](CO[Si](C)(C)C(C)(C)C)Cc2c(/C=C/C(C)(C)O)cccc21>>C[C@@H]1N[C@@H](CO[Si](C)(C)C(C)(C)C)Cc2c(CCC(C)(C)O)cccc21,[Pd],CCO,CCOC(C)=O,,,val
US05369018,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O.CC(C)C[C@H](N)C(N)=O>>CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(N)=O,,CS(C)=O,,,,val
US05935972,Cc1cc([N+](=O)[O-])cc2c1OCC2>>Cc1cc(N)cc2c1OCC2,[Pd],CCO,,,,val
US20150018547A1,CCOC(=O)CS.CCOC(=O)c1ccc(OCc2ccc(Cl)cc2Cl)cc1F>>CCOC(=O)c1sc2cc(OCc3ccc(Cl)cc3Cl)ccc2c1O,,CN(C)C=O,O,[Li+].[OH-],,val
US20070219181A1,COC(=O)c1nc(/C=C/c2ccc(-n3cnc(C)c3)c(OC)c2)[nH]c1-c1ccc(F)cc1>>COc1cc(/C=C/c2nc(C(=O)O)c(-c3ccc(F)cc3)[nH]2)ccc1-n1cnc(C)c1,,CO,,Cl,[Na+].[OH-],val
US20050049290A1,COC(=O)c1ccc(NCCCN(C)CCc2ccccn2)c(N)c1.COc1cc(N=C=S)cc(OC)c1>>COC(=O)c1ccc2c(c1)nc(Nc1cc(OC)cc(OC)c1)n2CCCN(C)CCc1ccccn1,,C1CCOC1,,CC(C)N=C=NC(C)C,,val
US20150232460A1,COc1cccc(OC)c1C(=O)N[C@H]1CCC[C@@H]1N.Fc1cccc(C(F)(F)F)n1>>COc1cccc(OC)c1C(=O)N[C@H]1CCC[C@@H]1Nc1cccc(C(F)(F)F)n1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,Cl,val
US20100075948A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.CC(C)(C)OC(=O)c1ccccc1N>>CC(C)(C)C[C@@H]1N[C@@H](C(=O)Nc2ccccc2C(=O)OC(C)(C)C)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040235867A1,CCN(CC)C(=O)CCl.Clc1ncnc2[nH]ccc12>>CCN(CC)C(=O)Cn1ccc2c(Cl)ncnc21,,CN(C)C=O,,[H-].[Na+],,val
US20010039285A1,COc1ccc2c(c1)CCNC2C1CCCCC1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COc1ccc2c(c1)CCN(C(=O)C(F)(F)F)C2C1CCCCC1,,ClCCl,,CCN(CC)CC,,val
US20120172601A1,CCCCO.O=C(O)CCc1ccccc1>>CCCCOC(=O)CCc1ccccc1,[Zn],,,CC(C)OC(C)C,,val
US03954776,ClCC1CO1.Oc1cccc(Cc2ccccn2)c1>>c1ccc(Cc2cccc(OCC3CO3)c2)nc1,,CO,,[Na+].[OH-],,val
US04101667,CCO.O=C(O)c1cccc2c1CCc1cc(O)ccc1S2>>CCOC(=O)c1cccc2c1CCc1cc(O)ccc1S2,,CCOC(C)=O,c1ccccc1,Cl,,val
US20080300242A1,COc1cc(Cl)ccc1[N+](=O)[O-].OB(O)c1ccncc1>>COc1cc(-c2ccncc2)ccc1[N+](=O)[O-],Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20140163000A1,O=[N+]([O-])c1cnccc1-n1cccn1>>Nc1cnccc1-n1cccn1,[Pd],CO,,,,val
US20120225867A1,NCC(Sc1ccccc1)c1ccc(Br)o1.O=C(O)c1ccccn1>>O=C(NCC(Sc1ccccc1)c1ccc(Br)o1)c1ccccn1,,C1CCOC1,,CCN=C=NCCCN(C)C,,val
US06159904,CCOC(=O)c1ccc2c(c1C)C(O)C(C)(C)CS2(=O)=O.CS(=O)(=O)Cl>>CCOC(=O)c1ccc2c(c1C)C(OS(C)(=O)=O)C(C)(C)CS2(=O)=O,,c1ccncc1,,,,val
US20160207885A1,COc1ccc(CBr)cc1.Ic1ccn[nH]1>>COc1ccc(Cn2nccc2I)cc1,,CC(=O)N(C)C,,[H-].[Na+],,val
US20130210844A1,Nc1cccc(C(F)(F)F)c1.O=[N+]([O-])c1cccc2c(Cl)nccc12>>O=[N+]([O-])c1cccc2c(Nc3cccc(C(F)(F)F)c3)nccc12,,CN1CCCC1=O,O,,,val
US20090270361A1,Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1C(O)c1ccc(Br)nc1.N#C[Cu]>>Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1C(O)c1ccc(C#N)nc1,,CN1CCCC1=O,,O=C([O-])O.[Na+],,val
US03953430,CN1c2ccccc2NC(=O)c2cscc21.ClCCN1CCCCC1>>CN1c2cscc2C(=O)N(CCN2CCCCC2)c2ccccc21,,CN(C)C=O,,Cl,[H-].[Na+],val
US20120094997A1,CCNCC.COC(=O)c1ccc2ccn(Cc3cccc(CBr)c3)c(=O)c2c1>>CCN(CC)Cc1cccc(Cn2ccc3ccc(C(=O)OC)cc3c2=O)c1,,C1CCOC1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060235029A1,CNCCN.Cc1ccc(C(=O)Nc2ccc(F)cc2)cc1-c1nc(S(C)=O)nc2c1ccc(=O)n2-c1c(F)cccc1F>>Cc1ccc(C(=O)Nc2ccc(F)cc2)cc1-c1nc(N(C)CCN)nc2c1ccc(=O)n2-c1c(F)cccc1F,,C1CCOC1,,,,val
US20020028832A1,CC(C)(C)[Si](Oc1ccc(OCC2CO2)cc1)(c1ccccc1)c1ccccc1.CCCCCCCCNC(=O)N1CCC(Nc2ccc(OCCN)cc2)CC1>>CCCCCCCCNC(=O)N1CCC(Nc2ccc(OCCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1,,CO,ClC(Cl)Cl,O=CO,,val
US20120269738A1,COCCOCCn1c2ccccc2c2cc(C=O)ccc21.Cc1cc[n+](CCO)c2ccccc12.[Cl-]>>COCCOCCn1c2ccccc2c2cc(/C=C/c3cc[n+](CCO)c4ccccc34)ccc21.[Cl-],,CCO,,C1CCNCC1,,val
US20070185155A1,BrCCCOc1ccc(OCc2ccccc2)cc1.OC(c1ccccc1)(c1ccccc1)C12CCN(CC1)CC2>>OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccc(OCc4ccccc4)cc3)(CC1)CC2.[Br-],,CC#N,,,,val
US04962103,CC(=O)O.N#CC[C@@H]1C[C@@H](OC(=O)c2ccccc2)CN1C(=O)OCc1ccc([N+](=O)[O-])cc1>>O=C(O)C[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccc([N+](=O)[O-])cc1,,Cl,,,,val
US20040259912A1,CC(C)(C)c1ccc(CCl)cc1.CCC(=O)c1cc([N+](=O)[O-])ccc1O>>CCC(=O)c1cc([N+](=O)[O-])ccc1OCc1ccc(C(C)(C)C)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06121285,C[C@@H](c1ccccc1)N1C[C@H](C2(NC(=O)OC(C)(C)C)CC2)[C@H](F)C1=O>>C[C@@H](c1ccccc1)N1C[C@H](C2(NC(=O)OC(C)(C)C)CC2)[C@H](F)C1,,C1CCOC1,,,,val
US20060025383A1,CS(=O)(=O)O[C@@H]1CC[C@H](n2nc(I)c3c(N)ncnc32)CC1.c1cn[nH]c1>>Nc1ncnc2c1c(I)nn2[C@@H]1CC[C@@H](n2cccn2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US05109010,CCOC(=O)CN(C(=O)Cc1ccc(OCc2ccccc2)cc1)c1ccc(SC)cc1.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)CN(C(=O)Cc1ccc(OCc2ccccc2)cc1)c1ccc(S(C)=O)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20140140956A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C(=O)c1ccc(Br)c(Cl)c1>>CN(C)C(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)c(Cl)c1,,C1COCCO1,,O,CC(=O)[O-].[K+],val
US20080021022A1,Cc1ccc(-c2oncc2C(=O)O)cc1.OCC1CNCC1c1ccccc1>>Cc1ccc(-c2oncc2C(=O)N2CC(CO)[C@H](c3ccccc3)C2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20090105259A1,Cc1ccc(S(=O)(=O)OC[C@H]2OC(C)(C)O[C@@H]2COS(=O)(=O)c2ccc(C)cc2)cc1>>Cc1ccc(S(=O)(=O)OC[C@@H](O)[C@H](O)COS(=O)(=O)c2ccc(C)cc2)cc1,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20160206616A1,CC(C)(C)OC(=O)N1CC(F)(F)C[C@@H]1CCC=O.CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)C=CCC[C@H]1CC(F)(F)CN1C(=O)OC(C)(C)C,,ClCCl,,,,val
US06060608,CCOC(=O)c1cc(OCc2ccccc2)c2ccc(Br)cc2c1.N#C[Cu]>>CCOC(=O)c1cc(OCc2ccccc2)c2ccc(C#N)cc2c1,,CN(C)C=O,,O,,val
US05352701,COC(=O)CCc1cc(C(=O)c2cccc(C(=O)OC)n2)ccc1OC>>COC(=O)CCc1cc(C(=O)c2cccc(C(=O)OC)n2)ccc1O,,Br,,,,val
US20130267510A1,O=[N+]([O-])c1ccc(Oc2cccc3c2COC3)cc1>>Nc1ccc(Oc2cccc3c2COC3)cc1,[Pd],CCO,,NN,O,val
US03953457,N#CBr.NNc1ccc2ccccc2n1>>Br.Nc1nnc2ccc3ccccc3n12,,CO,,,,val
US20090291951A1,CC(=O)Nc1nccc(CO)n1.O=S(Cl)Cl>>CC(=O)Nc1nccc(CCl)n1,,ClCCl,,,,val
US20030022881A1,CSc1c2sc(C3=C(C(=O)OCc4ccc([N+](=O)[O-])cc4)N4C(=O)[C@H]([C@@H](C)O)[C@H]4C3)c[n+]2cn1C.O=C(OO)c1cccc(Cl)c1.O=S(=O)([O-])C(F)(F)F>>C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(c3c[n+]4cn(C)c(S(C)=O)c4s3)C[C@H]12.O=S(=O)([O-])C(F)(F)F,,ClCCl,,CO,,val
US06251829B1,C=C(C)C(OC(=O)c1cc([N+](=O)[O-])c(F)cc1Cl)C(=O)OCC>>C=C(C)C(OC(=O)c1cc(N)c(F)cc1Cl)C(=O)OCC,[Zn],C1CCOC1,,[Cl-].[NH4+],,val
US20130267493A1,BrCCCOc1ccc(Br)cc1.O=C1COCCN1>>O=C1COCCN1CCCOc1ccc(Br)cc1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20060199838A1,COc1cc(C(=O)Nc2ccc3c(c2)OCO3)ccc1NS(C)(=O)=O>>CS(=O)(=O)Nc1ccc(C(=O)Nc2ccc(O)c(O)c2)cc1O,,ClCCl,,BrB(Br)Br,CO,val
US20040102450A1,CC(C)(C)OC(=O)N1CCC(CBr)CC1.O=C1CN(C(=O)OCc2ccccc2)CCN1>>CC(C)(C)OC(=O)N1CCC(CN2CCN(C(=O)OCc3ccccc3)CC2=O)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20040122007A1,COc1ccc2ccc([C@H](CO)NC(=O)OC(C)(C)C)cc2c1>>COc1ccc2ccc([C@@H](N)CO)cc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100093757A1,CCOC(=O)[C@H](CCN(C)C)O[Si](C)(C)C(C)(C)C.Cc1ccc(N)nc1>>Cc1ccc(NC(=O)[C@H](CCN(C)C)O[Si](C)(C)C(C)(C)C)nc1,,C1CCOC1,CCOC(C)=O,O,[Li]CCCC,val
US20150352090A1,O=C(O)c1cccc(S(=O)(=O)Cl)c1.O=C(O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1)[C@H]1NCCS1>>O=C(O)c1cccc(S(=O)(=O)N2CCS[C@H]2C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)c1,,c1ccncc1,,Cl,,val
US20120004240A1,Cc1cc2ncc3cc(-c4ccccc4)c(=O)[nH]c3n2n1.[Li]C>>Cc1cc2nc(C)c3cc(-c4ccccc4)c(=O)[nH]c3n2n1,O=[Mn]=O,C1CCOC1,,CCOC(C)=O,,val
US05530157,Brc1ccccc1OCc1ccccc1.C=CC(=O)OC>>COC(=O)C=Cc1ccccc1OCc1ccccc1,,CN(C)C=O,,CCN(CC)CC,,val
US20100298356A1,CCOC(CSc1cc(Cl)cc(OC)c1)OCC>>COc1cc(Cl)c2ccsc2c1,,ClCCl,,CCOCC,FB(F)F,val
US20080039499A1,NC1CCN(Cc2ccccc2)CC1.O=C(Nc1nc(C(=O)O)cs1)c1ccc(F)c(Cl)c1>>O=C(Nc1nc(C(=O)NC2CCN(Cc3ccccc3)CC2)cs1)c1ccc(F)c(Cl)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110118245A1,COc1cc2ncnc(Cl)c2cc1OC.O=C(Nc1ccc(F)c(O)c1)Nc1cc(C(F)(F)F)nn1-c1ccccc1>>COc1cc2ncnc(Oc3cc(NC(=O)Nc4cc(C(F)(F)F)nn4-c4ccccc4)ccc3F)c2cc1OC,,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05346910,C#CCN.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>C#CCNC(=O)C(F)(F)F,,ClCCl,,O,,val
US20050239827A1,CC(C)(C)OC(=O)NC[C@@H]1C[C@H](NC(=O)OC(C)(C)C)CN1C(=O)C(F)(F)F>>CC(C)(C)OC(=O)NC[C@@H]1C[C@H](NC(=O)OC(C)(C)C)CN1,,C1COCCO1,,O,[Li]O,val
US20100216788A1,CC(C)(C)OC(=O)NCCn1ccc2ncnc(Cl)c21.Nc1ccc2c(ccn2Cc2cccc(F)c2)c1>>CC(C)(C)OC(=O)NCCn1ccc2ncnc(Nc3ccc4c(ccn4Cc4cccc(F)c4)c3)c21,,CC(C)O,,O=C([O-])O.[Na+],,val
US05476933,COc1cc(=O)c2c([nH]c1=O)CC(C)C(C)C2>>CC1Cc2[nH]c(=O)c(O)cc(=O)c2CC1C,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US04107423,COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1>>COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1,,CO,,Cl,,val
US20150087663A1,COc1ncnc(OC)c1-c1ncnn1C>>Cn1ncnc1-c1c(O)ncnc1O,,CC(=O)O,,Cl,,val
US20050171154A1,Cl.N=C1CCCN1c1ccc([N+](=O)[O-])cc1>>Cl.N=C1CCCN1c1ccc(N)cc1,,CO,,O,,val
US04096143,NNCc1ccccc1.O=C(O)c1ccccc1C(Br)Br>>O=c1c2ccccc2cnn1Cc1ccccc1,,CCN(CC)CC,,Cl,Cl,val
US20130225561A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1ccc2c(c1)CCC(N)C2>>CC(C)(C)OC(=O)NC1CCc2cc(C#N)ccc2C1,,ClCCl,,,,val
US05472933,COC(=O)Cl.Cn1cccc1S(=O)(=O)NC(C)(C)C>>COC(=O)c1ccn(C)c1S(=O)(=O)NC(C)(C)C,,C1CCOC1,CCOC(C)=O,[Li]CCCC,,val
US20070021405A1,CNC(=O)COC(=O)N1CCC(CC#Cc2ccc(Cl)cc2)CC1>>CNC(=O)COC(=O)N1CCC(CCCc2ccc(Cl)cc2)CC1,O=[Pt]=O,CCO,,,,val
US20110003787A1,COC[C@H](C)Oc1cc(Oc2cnc(S(C)(=O)=O)cn2)cc(-c2ccc(C3=N[C@H](C)[C@H](C)O3)[nH]2)c1>>C[C@@H](CO)Oc1cc(Oc2cnc(S(C)(=O)=O)cn2)cc(-c2ccc(C3=N[C@H](C)[C@H](C)O3)[nH]2)c1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20100093724A1,CS(=O)(=O)NC1(NS(C)(=O)=O)C=C(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)C=CN1>>CS(=O)(=O)Nc1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US06248739B1,O=C(NCc1ccc(Cl)cc1)c1cnc2ccc(C#CCO)cc2c1O.OCCOCCCl>>O=C(NCc1ccc(Cl)cc1)c1cn(CCOCCO)c2ccc(C#CCO)cc2c1=O,,CN(C)C=O,O,[I-].[K+],,val
US20140066453A1,CC[C@@H](N[S@@](=O)C(C)(C)C)c1ccc(OC)c(F)c1.Cl>>CC[C@@H](N)c1ccc(OC)c(F)c1.Cl,,CCOCC,,CO,,val
US20050070521A1,O=C(O)C(=O)O.O=C([O-])[O-]>>O=C(O)C(=O)O.O=C(O)O,,CCOC(C)=O,,,,val
US20060287300A1,CC(C)CCC12C(=CC(=O)c3ccccc31)OC(C(C)C)N2OCc1ccccc1>>CC(C)CCC1(NOCc2ccccc2)C(O)=CC(=O)c2ccccc21,,C1CCOC1,Cl,,,val
US20070043013A1,CC(C)(C)OC(=O)NC1(CCN2CC(Oc3ccc(Cl)cc3)C2)CCC1>>NC1(CCN2CC(Oc3ccc(Cl)cc3)C2)CCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110015230A1,CCCNc1cc(C(F)(F)F)ccc1C=O.COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCNc1cc(C(F)(F)F)ccc1C=CC(=O)OC,,Cc1ccccc1,,,,val
US20110136819A1,CN1CCN(CCCO)CC1.Cl.O=C(Cl)OC(Cl)(Cl)Cl>>CN1CCN(CCCOC(=O)Cl)CC1.Cl.Cl,,CC#N,,,,val
US20090215803A1,CC(=O)c1ccc(O)c(C)c1.O=Cc1cccc(Cl)c1Cl>>Cc1cc(C(=O)/C=C/c2cccc(Cl)c2Cl)ccc1O,,CCO,O,Cl,[Na+].[OH-],val
US20100273782A1,N#Cc1ccc(Cl)c([N+](=O)[O-])c1.Oc1cc(Cl)ccc1Cl>>N#Cc1ccc(Oc2cc(Cl)ccc2Cl)c([N+](=O)[O-])c1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20100120881A1,COCC(O)C#N.CS(=O)(=O)Cl>>COCC(C#N)OS(C)(=O)=O,,O,,CCN(CC)CC,ClCCl,val
US20030176454A1,CC(=O)O.COC1CCC(OC)O1.Nc1cccc2c(Cl)nccc12>>Clc1nccc2c(-n3cccc3)cccc12,,CC(=O)O,,,,val
US20160096832A1,COc1ccc(COc2nccc(C)c2N2CCc3nc(N)ncc3C2)cc1>>Cc1cc[nH]c(=O)c1N1CCc2nc(N)ncc2C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020019436A1,CCNCC.Cn1cc(C(=O)c2ccc3ccccc3c2)cc1C(=O)CCl>>CCN(CC)CC(=O)c1cc(C(=O)c2ccc3ccccc3c2)cn1C,,CCO,,,,val
US20160272628A1,CC1c2cc(-c3cn(C(=O)OC(C)(C)C)c4cc(F)ccc34)ccc2S(=O)(=O)N1CCN1CCOC1=O>>CC1c2cc(-c3c[nH]c4cc(F)ccc34)ccc2S(=O)(=O)N1CCN1CCOC1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04337267,CCOC(=O)C1(CCCCCOc2ccc(Cl)cc2)CO1>>O=C(O)C1(CCCCCOc2ccc(Cl)cc2)CO1,,C1CCOC1,,[Na+].[OH-],,val
US20150148536A1,O=C(Nc1ccccc1-c1ccccc1)c1ccc(CCl)cc1>>ClCc1ccc(-c2nc3ccccc3c3ccccc23)cc1,,Cc1ccccc1,,O=P(Cl)(Cl)Cl,,val
US20060111411A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1cc(N)nn1CC(=O)OC(C)(C)C>>COC(=O)c1cc(NC(=O)OC(C)(C)C)nn1CC(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20140206682A1,COc1ccc2ncc(C(=O)O)n2c1.Nc1cc(C(=O)N[C@@H]2c3ccccc3C[C@@H]2O)ccc1F>>COc1ccc2ncc(C(=O)Nc3cc(C(=O)N[C@@H]4c5ccccc5C[C@@H]4O)ccc3F)n2c1,,ClCCl,c1ccncc1,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20160176825A1,C=CC(=O)Cl.COc1cc2ncnc(N(C)C(=O)NCc3ccccc3)c2cc1NC(=O)[C@@H]1CCCN1>>C=CC(=O)N1CCC[C@H]1C(=O)Nc1cc2c(N(C)C(=O)NCc3ccccc3)ncnc2cc1OC,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05238962,NCCO.O=C(Cl)c1ccc(Cl)cc1>>O=C(NCCO)c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20090181967A1,CC(C)(C)OC(=O)N1CCOCC1CO.O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCN(c2ccc(F)cc2F)CC1>>CC(C)(C)OC(=O)N1CCOCC1COC(=O)N1CCN(c2ccc(F)cc2F)CC1,,C1CCOC1,,[H-].[Na+],,val
US20060211712A1,CCOC(=O)c1ccc(Nc2ccccc2[N+](=O)[O-])cc1>>CCOC(=O)c1ccc(Nc2ccccc2N)cc1,[Pd],CCO,,,,val
US04863948,BrCCBr.Cc1n[nH]c(=O)c2ccccc12>>Cc1nn(CCBr)c(=O)c2ccccc12,,CN(C)C=O,,[H][H],[H-].[Na+],val
US20120309739A1,CC(C)(C)OC(=O)NC1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CCC1.Ic1oc2ncncc2c1-c1ccccc1>>CC(C)(C)OC(=O)NC1(c2ccc(-c3oc4ncncc4c3-c3ccccc3)cc2)CCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20120108583A1,COC(=O)c1cc2nc(Nc3c(Cl)cncc3Cl)n(C)c2c2c1OC(C)(C)C2.Nc1cc(C2CC2)ccc1F>>Cn1c(Nc2c(Cl)cncc2Cl)nc2cc(C(=O)Nc3cc(C4CC4)ccc3F)c3c(c21)CC(C)(C)O3,,Cc1ccccc1,,C[Al](C)C,,val
US05179100,CCOC(=O)CBr.Nc1c2c(nc3ccccc13)CCc1cn[nH]c1-2>>CCOC(=O)Cn1cc2c(n1)-c1c(nc3ccccc3c1N)CC2,,CN(C)C=O,,[H-].[Na+],,val
US20160185778A1,C=C[Mg]Br.CON(C)C(=O)C1CCCO1>>C=CC(=O)C1CCCO1,,C1CCOC1,,N#N,,val
US20100204265A1,O=C(O)c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1Cl.[C-]#N>>N#Cc1c(-c2ccoc2)cc(C(F)F)c2nc(C(=O)O)c(Cl)n12,,CN(C)C=O,,O,,val
US06313137B1,CC(=O)C(C)Br.CCOC(=O)c1cnc(N)c(N)c1>>CCOC(=O)c1cc(N)c2nc(C)c(C)n2c1,,COCCOC,,,,val
US20100298340A1,Cc1nc(N=C(N)N)sc1-c1ccc(N)cc1.O=C(O)c1cc2cc(F)ccc2[nH]1>>Cc1nc(NC(=N)N)sc1-c1ccc(NC(=O)c2cc3cc(F)ccc3[nH]2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070167430A1,CC(C)(C)OC(=O)N1CCC(c2nnc(COCc3cc(Cl)ccc3N)o2)CC1>>CC(C)(C)OC(=O)N1CCC(c2nnc3n2-c2ccc(Cl)cc2COC3)CC1,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080045526A1,O=C1Cc2cc(F)ccc2N1.O=C1OCc2ncccc21>>O=C1Nc2ccc(F)cc2C1=C1OCc2ncccc21,,C1CCOC1,,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20120277224A1,CCOC(=O)CC(=O)c1ccc2occ(C)c2c1.Nc1n[nH]c(N)c1-c1ccccn1>>Cc1coc2ccc(-c3cc(=O)n4nc(N)c(-c5ccccn5)c4[nH]3)cc12,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150274747A1,COC1COC2C(OCc3ccccc3)COC12>>COC1COC2C(O)COC12,[Pd],CCO,,,,val
US20150105373A1,CC(C)(C)OC(=O)NC(CO)c1ccc(OC(F)(F)F)cc1.O=C(O)C(F)(F)S(=O)(=O)F>>CC(C)(C)OC(=O)NC(COC(F)F)c1ccc(OC(F)(F)F)cc1,[Cu]I,CC#N,,[Cl-].[NH4+],,val
US20130252984A1,NCCN1CCCC1.O=C(O)c1cccc(CS(=O)(=O)c2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)c1>>O=C(NCCN1CCCC1)c1cccc(CS(=O)(=O)c2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)c1,CN(C)c1ccncc1,CN(C)C=O,,ClCCCl,,val
US20040167123A1,C1CCOC1.CC(C)C=Nn1c(=O)c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc21.CO>>O=c1c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc2n1NCCc1ccccc1,,C1CCOC1,O,Cl,[BH4-].[Li+],val
US20020040017A1,CCCC[Sn](CCCC)(CCCC)c1cccn1C.C[Si](C)(C)OS(=O)(=O)Cl.O=C([O-])O.[Na+]>>Cn1ccc(S(=O)(=O)[O-])c1.O.[Na+],,ClC(Cl)(Cl)Cl,,,,val
US20090275578A1,COC(=O)c1c(I)cccc1CBr.NCc1ccc(Cl)cc1>>O=C1c2c(I)cccc2CN1Cc1ccc(Cl)cc1,,CCCCCC,Cc1ccccc1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20110190342A1,N[C@H](Cc1c[nH]c2ccccc12)C(=O)O.O=C(O)c1cc2cc(Cl)ccc2nc1Cl>>O=C(O)c1cc2cc(Cl)ccc2nc1N[C@H](Cc1c[nH]c2ccccc12)C(=O)O,,O,,CC#N,,val
US04596872,O=C(c1ccc(Cl)cc1)C1CC1.c1c[nH]cn1>>Clc1ccc(C2=CCCn3ccnc32)cc1,,ClCCl,,,,val
US05935972,CCCC[Sn](CO)(CCCC)CCCC.O=Cc1cc(Br)cc2ccoc12>>O=Cc1cc(CO)cc2ccoc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20050148623A1,COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCN(Cc2ccccc2)C1=O)C(C)(C)C)C(C)(C)C.O=C(Cl)OCCl>>COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](OC(=O)OCCl)[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCN(Cc2ccccc2)C1=O)C(C)(C)C)C(C)(C)C,,CCOC(C)=O,c1ccncc1,,,val
US04643849,CSC(=C[N+](=O)[O-])S(C)=O.NCCCl>>CSC(=C[N+](=O)[O-])NCCCl,,CCN(CC)CC,,CCO,Cl,val
US20100216758A1,CC(C)(C)[Si](C)(C)OCCN1CCCC1c1ccc(CCn2ccc(OCc3ccc(F)cc3)cc2=O)cc1.CI>>COCCN1CCCC1c1ccc(CCn2ccc(OCc3ccc(F)cc3)cc2=O)cc1,,C1CCOC1,,[H-].[Na+],,val
US20050059678A1,CCOc1cc2ncc(C#N)c(Cl)c2cc1NC(C)=O.Nc1ccc(OCc2ccccc2)c(Cl)c1>>CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccc4)c(Cl)c3)c2cc1NC(C)=O,,CC(C)O,,Cl,c1ccncc1,val
US20110152273A1,CI.Cc1cccc(Nc2nc(Cl)nc(Cl)c2C(=O)O)c1>>COC(=O)c1c(Cl)nc(Cl)nc1Nc1cccc(C)c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20060269473A1,CN(C(=O)OC(C)(C)C)c1ccc(C=Cc2ccc(OCCOCCF)cc2)cc1>>CNc1ccc(C=Cc2ccc(OCCOCCF)cc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150166480A1,COC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1c(F)cccc1-c1ccc(OCC2CCN(CC(C)(C)F)CC2)cc1>>CC(C)(F)CN1CCC(COc2ccc(-c3cccc(F)c3C(=O)N3C[C@H](O)C[C@H]3C(=O)O)cc2)CC1,,C1CCOC1,,O,[Li]O,val
US20070213333A1,CC(C)OB(OC(C)C)OC(C)C.CCCCCC.O=S(=O)(O)O.[Li]CCCC>>OB(O)c1ccc2ccc(O)cc2c1,,C1CCOC1,O,[H-].[Na+],,val
US20160102059A1,N#Cc1cc([N+](=O)[O-])ccc1OCCCN1CCOCC1>>N#Cc1cc(N)ccc1OCCCN1CCOCC1,[Fe],CCO,O,[Cl-].[NH4+],,val
US05859007,CC(C)(C)OC(=O)n1nc(CBr)c2ccccc21.CC(C)N(C(=O)CN1C(=O)CC(=O)N(c2ccccc2)c2ccccc21)c1ccc2c(c1)OCO2>>CC(C)N(C(=O)CN1C(=O)C(Cc2nn(C(=O)OC(C)(C)C)c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc2c(c1)OCO2,,CN(C)C=O,,O,[H-].[Na+],val
US20050187230A1,CSc1ncc(C=O)c(N)n1.N#CCc1c(Cl)ccc(N)c1Cl>>CSc1ncc2cc(-c3c(Cl)ccc(N)c3Cl)c(N)nc2n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120059028A1,CCCC(C(=O)OC)c1c(-c2ccccc2)nc2sc3c(c2c1-c1ccc(C)cc1)CCC3>>CCCC(C(=O)O)c1c(-c2ccccc2)nc2sc3c(c2c1-c1ccc(C)cc1)CCC3,,CO,,[Na+].[OH-],,val
US20090124618A1,CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(O)cc2)C1.OCCCBr>>CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(OCCCBr)cc2)C1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080287434A1,CC(c1ccc(Cl)c(Cl)c1)N(C)CCC#N>>CC(c1ccc(Cl)c(Cl)c1)N(C)CCCN,[Ni],CO,,,,val
US20130210838A1,CC(C)(C)OC(=O)N[C@@H]1CCCC(F)(F)[C@@H]1N.CCc1sc(C(=O)O)cc1Br>>CCc1sc(C(=O)N[C@@H]2[C@H](NC(=O)OC(C)(C)C)CCCC2(F)F)cc1Br,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20130172331A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.COC(=O)c1ncc(Br)cc1Cl>>C=C(OCC)c1cnc(C(=O)OC)c(Cl)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20080009530A1,CCOC(=O)/C=C/c1ccc(OCCOC)cc1OCC1CC1>>COCCOc1ccc(/C=C/C(=O)O)c(OCC2CC2)c1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20110086834A1,COc1ccc(CN2CC3(CN(C)C3)c3ccc(OCc4ccccc4)cc32)cc1.Cl>>CN1CC2(CNc3cc(O)ccc32)C1.Cl,[Pd],CCO,,O,,val
US20080004302A1,Clc1nccc(Nc2cc(CCc3ccccc3)n[nH]2)n1.NCc1cc(C(N)=O)no1>>NC(=O)c1cc(CNc2nccc(Nc3cc(CCc4ccccc4)n[nH]3)n2)on1,,COCCO,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20150141406A1,COc1nccc(I)c1C(=O)NNc1ccccc1>>COc1nccc2c1c(=O)[nH]n2-c1ccccc1,[Cu]I,CS(C)=O,,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US20130023526A1,COc1cc(CNC(=O)c2cc(C3=NOC(C4CCNCC4)C3)nc(C)n2)ccc1F.O=C([O-])C(F)(c1c(F)c(F)c(F)c(F)c1F)S(=O)(=O)C(F)(F)F>>COc1cc(CNC(=O)c2cc(C3=NOC(C4CCN(C(=O)CS(C)(=O)=O)CC4)C3)nc(C)n2)ccc1F,,ClCCl,,Cl,,val
US20110028494A1,Clc1nccc2ccc(Br)cc12.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1ccc2ccc(Br)cc2c1Cl,,ClCCl,,,,val
US20140194431A1,O=C1c2c(OCc3ccccc3)c(=O)nc(CC3(c4ccc(Cl)cc4)CCCC3)n2CCN1C1CC1>>O=C1c2c(O)c(=O)nc(CC3(c4ccc(Cl)cc4)CCCC3)n2CCN1C1CC1,,CC(=O)O,,O=S(=O)(O)O,,val
US20150361029A1,COC(Cl)Cl.Cc1cc(O[C@@H]2CC[C@@H](C(C)(C)C)CC2)cc2ccccc12>>Cc1cc(O[C@@H]2CC[C@@H](C(C)(C)C)CC2)c(C=O)c2ccccc12,,ClCCl,,Cl[Sn](Cl)(Cl)Cl,,val
US20120040980A1,CI.O=C(O)c1c(Cl)cc(Cl)c(O)c1[N+](=O)[O-]>>COc1c(Cl)cc(Cl)c(C(=O)O)c1[N+](=O)[O-],,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US04230707,CC(C)c1cc2c(=O)n3cc(C(N)=O)ccc3nc2s1>>CC(C)c1cc2c(=O)n3cc(C#N)ccc3nc2s1,,O=P(Cl)(Cl)Cl,,ClC(Cl)Cl,,val
US04058550,CCCCCCCCCCCCCCCCNc1ccc(C(=O)O)cc1.OCC(O)CCl>>CCCCCCCCCCCCCCCCNc1ccc(C(=O)OCC(O)CO)cc1,,CN(C)P(=O)(N(C)C)N(C)C,,[H-].[Na+],,val
US20040266845A1,FC(F)(F)Oc1ccc(Nc2nc3ccccc3s2)cc1.O=C(Cl)c1ccccc1Cl>>O=C(c1ccccc1Cl)N(c1ccc(OC(F)(F)F)cc1)c1nc2ccccc2s1,,C1CCOC1,,O,,val
US05939439,COC(=O)c1ccc(-c2ccccc2)c(C#N)c1>>N#Cc1cc(CO)ccc1-c1ccccc1,,C1CCOC1,,[BH4-].[Li+],,val
US20110071150A1,Cc1c(-c2c(F)cccc2F)n(Br)c2ccccc12.Cn1nc(C(F)(F)F)cc1B(O)O>>Cc1cc(-c2ccc3[nH]c(-c4c(F)cccc4F)c(C)c3c2)n(C)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20060094716A1,Cc1cc(C(=O)O)cc(C=Cc2ccccc2)n1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cc1cc(C(=O)N=[N+]=[N-])cc(C=Cc2ccccc2)n1,,CN(C)C=O,,,,val
US20100029621A1,CC(C)(O)CNC(=O)Nc1ccc(C(=O)N2CCN(Cc3ccc(C(O[Si](C)(C)C(C)(C)C)(C(F)(F)F)C(F)(F)F)cc3)CC2)cc1Cl>>CC(C)(O)CNC(=O)Nc1ccc(C(=O)N2CCN(Cc3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)cc1Cl,,C1CCOC1,,[F-].[K+],,val
US20150133424A1,N.O=C(NC1(C(=O)O)CC1)c1cccc([N+](=O)[O-])c1>>NC(=O)C1(NC(=O)c2cccc([N+](=O)[O-])c2)CC1,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US04714492,CCOC(=O)c1c(-c2ccccc2)n(C)c(CC)cc1=O>>CCc1cc(=O)c(C(=O)O)c(-c2ccccc2)n1C,,[Na+],[OH-],Cl,,val
US20150259346A1,O=C1CC(C(F)(F)F)c2ccccc2N1>>FC(F)(F)C1CCNc2ccccc21,,C1CCOC1,,B,CSC,val
US03970754,C1CCNCC1.COS(=O)(=O)[O-].Cn1c(Cl)cc(-c2ccccc2)[n+]1C>>COS(=O)(=O)[O-].Cn1c(-c2ccccc2)cc(N2CCCCC2)[n+]1C,,CCO,,,,val
US04394515,CC(=O)O.N#Cc1ccc2c(c1)Sc1ccccc1C=C2.O>>O=C(O)c1ccc2c(c1)Sc1ccccc1C=C2,,O,,Cl,,val
US04262128,CCOC(=O)CCCCCCC(N)C(=O)OCC.CI.O=Cc1ccccc1>>CCOC(=O)CCCCCCC(C)(N=Cc1ccccc1)C(=O)OCC,,c1ccccc1,,,,val
US20050261501A1,CCOC(=O)CCC1(CCC(=O)OCC)CCC1>>CCOC(=O)C1CC2(CCC2)CCC1=O,,C1CCOC1,,CC(=O)O,[H-].[Na+],val
US20130090334A1,Cc1cc(Br)ncc1Br.Nc1ncc(B(O)O)cn1>>Cc1cc(-c2cnc(N)nc2)ncc1Br,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20040009979A1,CC(=O)Nc1ccc(S(=O)(=O)c2ccc([N+](=O)[O-])c(Cl)c2)cc1>>CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2Cl)cc1,[Fe],CCO,,Cl,O,val
US05134152,CC(OS(C)(=O)=O)C(C)(C)C(O)(Cn1cncn1)c1ccc(F)cc1F>>CC1OC(Cn2cncn2)(c2ccc(F)cc2F)C1(C)C,,C1CCOC1,O,CO,[H-].[Na+],val
US05777113,C1CO1.CCCCN(C(C)=O)C1CC(C)(C)NC(C)(C)C1>>CCCCN(C(C)=O)C1CC(C)(C)N(CCO)C(C)(C)C1,,CCO,O,CCN(CC)CC,CCOC(C)=O,val
US20160052898A1,CC(C)(C)c1ccc(N)cc1NC(=O)CN1CCOCC1.O=C(O)c1ccc(-c2ccccc2)cc1>>CC(C)(C)c1ccc(NC(=O)c2ccc(-c3ccccc3)cc2)cc1NC(=O)CN1CCOCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US06291616B1,C[Si](C)(C)CCO.O=C(O)COCCOCCOCc1ccccc1>>C[Si](C)(C)CCOC(=O)COCCOCCOCc1ccccc1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20060135552A1,CC(=O)CC(=O)C1CC1.COC(=O)c1ccc(C(=O)c2c(N)sc3c2CCCC3)cc1>>COC(=O)c1ccc(-c2c(C(=O)C3CC3)c(C)nc3sc4c(c23)CCCC4)cc1,O=S(=O)(O)O,CC(=O)O,,,,val
US20090118333A1,COC(=O)c1ccc(C(C)(C)C)cc1O.Fc1cccc(C(F)(F)F)n1>>COC(=O)c1ccc(C(C)(C)C)cc1Oc1cccc(C(F)(F)F)n1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05234946,C=O.CCN(C/C=C/C#CC(C)(C)C)Cc1cccc(NCc2cccc(-c3ccsc3)c2)c1>>CCN(C/C=C/C#CC(C)(C)C)Cc1cccc(N(C)Cc2cccc(-c3ccsc3)c2)c1,,CC#N,,[BH3-]C#N.[Na+],,val
US06169107A,COC(=O)c1cc2ccccc2n1O.Cl.N=C(N)N>>Cl.NC(=NC(=O)c1cc2ccccc2[nH]1)NO,,CO,,C[O-].[Na+],,val
US04343811,CCOC(=O)CCCCBr.CCOC(=O)c1[nH]c2ccc(OCc3ccccc3)cc2c1-c1ccccc1>>CCOC(=O)CCCCn1c(C(=O)OCC)c(-c2ccccc2)c2cc(OCc3ccccc3)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20080167307A1,CC(C)(C)OC(=O)C(C)(C)Sc1nc(CC(=O)O)cs1.Nc1cc(-c2ccc(Cl)cc2)n[nH]1>>CC(C)(Sc1nc(CCNc2cc(-c3ccc(Cl)cc3)n[nH]2)cs1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060100431A1,CC(C)(C)OC(=O)N1C[C@H](O)[C@@H]2[C@H]1CCN2C(=O)OCC1c2ccccc2-c2ccccc21>>CC(C)(C)OC(=O)N1CC(=O)[C@@H]2[C@H]1CCN2C(=O)OCC1c2ccccc2-c2ccccc21,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20020103253A1,COC(=O)c1oc(C(C)(C)C)cc1N.Cc1ccc(N)cc1.O=C(Cl)Cl>>COC(=O)c1oc(C(C)(C)C)cc1NC(=O)Nc1ccc(C)cc1,,CCOC(C)=O,Cc1ccccc1,c1ccncc1,,val
US20040053786A1,CNC(=O)c1cccc2cccc(C(=O)O)c12>>CN=C1OC(=O)c2cccc3cccc1c23,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US04408077,COc1ccc2c(C)cccc2c1C(F)(F)F.O=C1CCC(=O)N1Br>>COc1ccc2c(CBr)cccc2c1C(F)(F)F,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US03974161,CCOC(=O)c1nc2nc3cc(OC)c(OC)cc3cc2c(=O)[nH]1.NO>>COc1cc2cc3c(=O)[nH]c(C(=O)NO)nc3nc2cc1OC,,CCO,,CCN(CC)CC,Cl,val
US20030216444A1,CC=O.COc1cc(C)c(C(O)c2c(C(F)(F)F)cc(Cl)nc2Cl)c(OC)c1OC>>COc1cc(C)c(C(O)c2c(Cl)nc(Cl)c(C(C)O)c2C(F)(F)F)c(OC)c1OC,,C1CCOC1,O,CC(C)NC(C)C,[Li]CCCC,val
US20070149546A1,C1COCCOCCOCCOCCO1.CC(=O)N(C)C.CN(C)CCO.Cc1cc(Nc2ncnc3cccc(F)c23)ccc1O>>Cc1cc(Nc2ncnc3cccc(OCCN(C)C)c23)ccc1OCc1ccccn1,,CC(=O)N(C)C,,[H-].[Na+],,val
US05066658,C=CCCCCCCCCC(O)CC(=O)OCC>>C=CCCCCCCCCC(O)CC(=O)O,,C1COCCO1,O,[Na+].[OH-],,val
US20130261151A1,CC(C)CCn1c(Cn2c(=O)n(C3CC3)c3ccncc32)nc2cc(Br)cnc21.N#C[Zn]C#N>>CC(C)CCn1c(Cn2c(=O)n(C3CC3)c3ccncc32)nc2cc(C#N)cnc21,,C1COCCO1,,CCN(CC)CC,,val
US20070287715A1,O=[N+]([O-])c1cc(Br)ccc1O.OC1CCCC1>>O=[N+]([O-])c1cc(Br)ccc1OC1CCCC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050187387A1,CCOC(=O)c1cc(=O)c2cc(C#N)c(Cl)cc2o1>>N#Cc1cc2c(=O)cc(C(=O)O)oc2cc1Cl,,CC(=O)O,,Cl,,val
US20140323518A1,CC(C)(C)[Si](C)(C)Cl.Cc1noc(C)c1-c1c(C=O)cc(C(F)(F)F)cc1-c1ccc(O)cc1>>Cc1noc(C)c1-c1c(C=O)cc(C(F)(F)F)cc1-c1ccc(O[Si](C)(C)C(C)(C)C)cc1,,ClCCl,,CCN(CC)CC,,val
US20140162985A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Fc1ccc(-n2ncc3ccc(Br)cc32)cc1>>CC1(C)OB(c2ccc3cnn(-c4ccc(F)cc4)c3c2)OC1(C)C,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20140213586A1,COc1cccc(N)c1.O=Cc1cccnn1>>COc1cccc(N=Cc2cccnn2)c1,,CCO,,,,val
US20080108608A1,Cn1nc(C2CC2)cc1NC(=O)Oc1ccccc1.Nc1cccc(C#Cc2cnc(N)nc2)c1>>Cn1nc(C2CC2)cc1NC(=O)Nc1cccc(C#Cc2cnc(N)nc2)c1,,C1CCOC1,,CCN(CC)CC,,val
US20040063768A1,CCOC(=O)C1=C(c2c[nH]c3ccc(C#N)cc23)CCC1>>CCOC(=O)[C@@H]1CCC[C@@H]1c1c[nH]c2ccc(C#N)cc12,[Pd],CO,,,,val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.COc1cccc(N)c1OC>>COc1ccc2nc(Nc3cccc(OC)c3OC)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US05877204,O=C(O)/C=C\C(=O)NCCCCCCOc1ccc(C(=O)c2ccccc2)cc1>>O=C(c1ccccc1)c1ccc(OCCCCCCN2C(=O)C=CC2=O)cc1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20030229113A1,COc1ccc(S(=O)(=O)N2Cc3nccnc3CC2C(=O)NOCc2ccccc2)cc1>>COc1ccc(S(=O)(=O)N2Cc3nccnc3CC2C(=O)NO)cc1,[Pd],C1CCOC1,CO,,,val
US20090048239A1,COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc(OCc4ccccn4)cc3OC[C@@H]3CO3)[nH]c2c1>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)C[C@H](O)COc1cc(OCc2ccccn2)ccc1-3,,CCOCC,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130059834A1,CC(NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12)C1CNC1.CS(=O)(=O)Cl>>CC(NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12)C1CN(S(C)(=O)=O)C1,,ClCCl,,CCN(CC)CC,Cl,val
US20110065702A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1n[nH]c2ccc(C=O)cc12>>CC(C)(C)OC(=O)Nc1n[nH]c2ccc(C=O)cc12,,CN(C)C=O,,CCN(CC)CC,,val
US20120010183A1,O=Cc1ccc(F)cc1.Oc1cnc(C(F)(F)F)c(Cl)c1>>O=Cc1ccc(Oc2cnc(C(F)(F)F)c(Cl)c2)cc1,,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20050222228A1,FC(F)(F)c1ccc(C=Cc2nc(COc3ccc(C#CCCn4ccnn4)nn3)co2)cc1>>FC(F)(F)c1ccc(C=Cc2nc(COc3ccc(C=CCCn4ccnn4)nn3)co2)cc1,[Pd],CCOC(C)=O,,,,val
US20100004208A1,COc1cc(C(=O)c2c([Si](C)(C)C(C)(C)C)oc3c(OC(C)C)c(OC)ccc23)cc(OC)c1OC>>COc1cc(C(=O)c2coc3c(OC(C)C)c(OC)ccc23)cc(OC)c1OC,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05985902,COc1ccc(-c2noc(C)c2-c2ccc(SC)cc2)cc1F.O=C=O>>COc1ccc(C(=O)Cc2ccc(SC)cc2)cc1F,,CCOCC,O,C1CCOC1,[Li]CCCC,val
US20050107305A1,COC(=O)[C@@H](N)CCCNC(=N)N.COc1ccc(N=NC(=O)N[C@@H](Cc2ccccc2)C(=O)O)cc1>>COc1ccc(N=NC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)cc1,,CO,O,[Na+].[OH-],,val
US20080214580A1,COC(OC)OC.Nc1ccc(F)cc1Nc1nc(Cl)c2[nH]c(=O)n([C@@H]3CCOc4c(F)cccc43)c2n1>>O=c1[nH]c2c(Cl)nc(-n3cnc4ccc(F)cc43)nc2n1[C@@H]1CCOc2c(F)cccc21,,CO,,CS(=O)(=O)O,,val
US20160122341A1,CCCC[C@H](CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cc(Cl)cn12.O=S(Cl)Cl>>CCCC[C@H](CCl)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cc(Cl)cn12.Cl,,ClCCl,,,,val
US05146002,C1CCOC1.CC(=O)C(C)(C)C.COC(=O)c1cccc(C(=O)OC)c1>>CC(C)(C)C(=O)CC(=O)c1cccc(C(=O)CC(=O)C(C)(C)C)c1,,C1CCOC1,,Cl,[H-].[Na+],val
US20050222142A1,Cc1c(C(=O)O)[nH]c2ccc(F)cc12>>Cc1c[nH]c2ccc(F)cc12,[Cu],c1ccc2ncccc2c1,,,,val
US20060074096A1,CC(C)=Cc1ncc(-c2ccnc(Nc3ccccc3)n2)n1C>>CC(C)Cc1ncc(-c2ccnc(Nc3ccccc3)n2)n1C,[Pd],CCO,,,,val
US20050119320A1,CC(=O)Cl.Cc1csc(N)n1>>CC(=O)Nc1nc(C)cs1,,c1ccncc1,,O,,val
US20140303164A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Fc1c(Br)cnc2[nH]ccc12>>OB(O)c1cnc2[nH]ccc2c1F,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20050245741A1,CC(C)(C)OC(=O)N1CCOC(CO)C1.O=C(O)C(F)(F)F>>O=C(OCC1CNCCO1)C(F)(F)F,,ClCCl,,,,val
US20030216432A1,COc1ccc(C=O)c(F)c1.OCCO>>COc1ccc(C2OCCO2)c(F)c1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20040152702A1,COc1ccc(N)c2oc(N)nc12.ICCOCCI>>COc1ccc(N2CCOCC2)c2oc(N)nc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130059845A1,CI.O=c1[nH]nc(-c2c(-c3cc(Cl)ccc3Cl)nc3ccccn23)n1-c1ccc(Cl)cc1>>COc1nnc(-c2c(-c3cc(Cl)ccc3Cl)nc3ccccn23)n1-c1ccc(Cl)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20110070317A1,CC(C)(C)OC(=O)N[C@@H]1CCCNC1.O=C(CC1CC1)Nc1c[nH]c2ncc(Br)c(F)c12>>CC(C)(C)OC(=O)N[C@@H]1CCCN(c2c(Br)cnc3[nH]cc(NC(=O)CC4CC4)c23)C1,,CCCCO,,CCN(CC)CC,,val
US20040146462A1,CCCCCCCCCCCCCCCCO.CN(C)CC(=O)O.Cl>>CCCCCCCCCCCCCCCCOC(=O)CN(C)C.Cl,,C1COCCO1,Cl,,,val
US20060111351A1,Cc1noc(C)c1B(O)O.O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Br)cc1>>Cc1noc(C)c1-c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US06887881B1,CC(C)(C)OC(=O)N1CC2CNCC(C2)C1.N#Cc1ccc(OCC2CN2C(=O)OCc2ccccc2)cc1>>CC(C)(C)OC(=O)N1CC2CC(CN(CC(COc3ccc(C#N)cc3)NC(=O)OCc3ccccc3)C2)C1,,CC(C)O,,,,val
US20110150864A1,O=C1CCC(=O)N1Cl.O=Cc1ccc2[nH]ncc2c1>>O=Cc1ccc2[nH]nc(Cl)c2c1,,CC#N,,,,val
US03957922,CC1CO1.O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl.c1ccc(OP(Oc2ccccc2)Oc2ccccc2)cc1>>CC1CO1.O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl.c1ccc(OP(Oc2ccccc2)Oc2ccccc2)cc1,[Fe],CCN(CC)CC,,[Al],,val
US20060020039A1,CCOC(=O)c1cc(C)n[nH]1.Nc1ccc(Br)cn1>>Cc1cc(C(=O)Nc2ccc(Br)cn2)[nH]n1,,ClCCl,,C[Al](C)C,,val
US20130012518A1,Cc1ccc([N+](=O)[O-])cc1N1CCC2(CC1)OCCO2>>Cc1ccc(N)cc1N1CCC2(CC1)OCCO2,[Pd],CO,,C1CCOC1,,val
US20130274255A1,C[Si](C)(C)CCOCn1nc(-c2ccc(N3CCOCC3)cc2)c2c1-c1cc(-c3ccc(N)nc3)sc1C2.Cl>>Cl.Nc1ccc(-c2cc3c(s2)Cc2c(-c4ccc(N5CCOCC5)cc4)n[nH]c2-3)cn1,,CO,,,,val
US20080051418A1,CCOC(=O)c1nc(C(C)C)sc1Cc1ccc(Cl)cc1Cl>>CC(C)c1nc(C=O)c(Cc2ccc(Cl)cc2Cl)s1,,C1CCOC1,Cc1ccccc1,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US20070249722A1,COC(=O)C(N)C(C(F)(F)F)C(F)(F)F.O=S(=O)(Cl)c1ccc(Cl)cc1>>COC(=O)C(NS(=O)(=O)c1ccc(Cl)cc1)C(C(F)(F)F)C(F)(F)F,,ClCCl,,CCOC(C)=O,c1ccncc1,val
US20120252777A1,CC1(C)OB(c2ccc(C(=O)NCCc3cc[nH]c(=O)c3)cc2)OC1(C)C.COc1ccc(Nc2nc(Cl)nc3scnc23)cc1OC>>COc1ccc(Nc2nc(-c3ccc(C(=O)NCCc4cc[nH]c(=O)c4)cc3)nc3scnc23)cc1OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US04362744,CC1(C)[C@H](C=C(Cl)C(F)(F)F)[C@@H]1C(=O)Cl.O[C@@H]1C[C@@H](Cc2cccc(F)c2)c2ccccc21>>CC1(C)[C@H](C=C(Cl)C(F)(F)F)[C@@H]1C(=O)O[C@@H]1C[C@@H](Cc2cccc(F)c2)c2ccccc21,,Cc1ccccc1,,c1ccncc1,,val
US06107329,NCC(=O)N1CCSC1.O=C(O)c1cc2cc(Cl)ccc2[nH]1>>O=C(NCC(=O)N1CCSC1)c1cc2cc(Cl)ccc2[nH]1,,CCOC(C)=O,,Cl,Cl,val
US04505739,CC(C)(C)c1cc(N)n[nH]1.O=C(Cl)C1CCC1>>CC(C)(C)c1cc(NC(=O)C2CCC2)n[nH]1,,ClC(Cl)(Cl)Cl,ClCCl,CCN(CC)CC,O,val
US05739354,C=CCC(F)(F)C(=O)O.O=C(Cl)C(=O)Cl>>C=CCC(F)(F)C(=O)Cl,CN(C)C=O,,,,,val
US20050124662A1,COCOc1ccc(-c2ccc3cnn(S(=O)(=O)c4c(C)cc(C)cc4C)c3c2)cc1OC>>COCOc1ccc(-c2ccc3cn[nH]c3c2)cc1OC,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20130096121A1,Cc1ccnn1C.O=C1CCCCC1>>Cc1ccnn1CC1(O)CCCCC1,,C1CCOC1,,[Li]CCCC,,val
US20160122336A1,CCN(CC)S(F)(F)F.C[C@H]1C[C@H](O)CCN1C(=O)OC(C)(C)C>>C[C@H]1C[C@@H](F)CCN1C(=O)OC(C)(C)C,,ClCCl,,,,val
US20150232476A1,CCN1CCc2c(sc(N)c2C(N)=O)C1.O=C(O)C1(c2ccc(Cl)cc2)CC1>>CCN1CCc2c(sc(NC(=O)C3(c4ccc(Cl)cc4)CC3)c2C(N)=O)C1,CN(C)C=O,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20060135540A1,COC(=O)CCn1cc(S(=O)(=O)c2ccc(C)cc2)c2ccc(OC)cc21>>COc1ccc2c(S(=O)(=O)c3ccc(C)cc3)cn(CCC(=O)O)c2c1,,C1CCOC1,,[K+].[OH-],,val
US05739162,N#Cc1cccc(N)c1.NCC(=O)Nc1ccccc1C(=O)c1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>N#Cc1cccc(NC(=O)NCC(=O)Nc2ccccc2C(=O)c2ccccc2)c1,,C1CCOC1,,Br,CCN(CC)CC,val
US20110003845A1,O=Cc1ccc(O)cc1.OC[C@H](O)CCl.[CH2-]C(C)=O>>CC1(C)OC[C@@H](COc2ccc(C=O)cc2)O1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080096922A1,COc1cccc(CC#N)c1.COc1ccccc1N(CCCCl)C(=O)CCl>>COc1cccc(C2(C#N)CCCN(c3ccccc3OC)CC2)c1,,CS(C)=O,,[H-].[Na+],[Cl-].[NH4+],val
US05624943,COC(=O)/C=C/c1nc(C(=O)CCCC(=O)OC)ccc1OC>>COC(=O)CCCC(O)c1ccc(OC)c(CCC(=O)OC)n1,[Pd],C1CCOC1,CO,,,val
US20140127240A1,CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@]1(C(=O)N2CCCCO2)C[C@@H]1c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C.O=CCCNC(=O)OCc1ccccc1>>CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@]1(C(=O)N2CCCCO2)C[C@@H]1c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCCN)C(C)C,[Pd],CCO,,O=C(O)C(F)(F)F,,val
US20090048236A1,CCCC[Sn](CCCC)(CCCC)N=[N+]=[N-].COC(=O)c1c(Cl)cc(C#N)cc1Cl>>COC(=O)c1c(Cl)cc(-c2nnn[nH]2)cc1Cl,,Cc1ccccc1,,,,val
US20120058984A1,C1COCCN1.ClCc1cncc(Br)c1>>Brc1cncc(CN2CCOCC2)c1,,CO,,Cl,,val
US20120040020A1,CC(C)(C)OC(=O)N1CC=C(c2cnc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(-c3nnc(-c4ccccc4)o3)n2)CC1>>Nc1ncc(C2=CCNCC2)nc1-c1nnc(-c2ccccc2)o1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150080438A1,CC(=O)SCCC(F)(F)C(F)(F)F.ClCCCBr>>FC(F)(F)C(F)(F)CCSCCCCl,,CO,,,,val
US20120149691A1,COc1ccc(C(C)(C)Nc2c(C#N)cnn3cccc23)cc1OC.OO>>COc1ccc(C(C)(C)Nc2c(C(N)=O)cnn3cccc23)cc1OC,,CCO,,[NH4+].[OH-],,val
US04338333,COC(=O)COc1ccc(CC(C)NCC(O)c2ccccc2)cc1.N>>CC(Cc1ccc(OCC(N)=O)cc1)NCC(O)c1ccccc1,,CO,,,,val
US20060046980A1,COc1ccc(Oc2c(C)cc(C=O)cc2C)cc1C(C)C.O=C(OO)c1cccc(Cl)c1>>COc1ccc(Oc2c(C)cc(O)cc2C)cc1C(C)C,,CCOC(C)=O,ClCCl,Cl,[Na+].[OH-],val
US20060241302A1,Fc1ccc(F)c(C(Sc2ccc(Cl)cc2)c2cc(Cl)ncc2Cl)c1.NCCc1ccncc1>>Fc1ccc(F)c(C(Sc2ccc(Cl)cc2)c2cc(NCCc3ccncc3)ncc2Cl)c1,,CO,,C1COCCO1,,val
US20120101127A1,CC1(C)CC(c2cccc(N)c2)Nc2ccc(Cl)cc21.CS(=O)(=O)Cl>>CC1(C)CC(c2cccc(NS(C)(=O)=O)c2)Nc2ccc(Cl)cc21,,c1ccncc1,,,,val
US20090286842A1,C=C(c1nc[nH]c1C)c1cccc2ccccc12>>Cc1[nH]cnc1C(C)c1cccc2ccccc12,[Pd],CCO,,,,val
US20140010783A1,CC(=O)Nc1ccc(C#N)c(S(=O)(=O)C(F)(F)F)c1>>N#Cc1ccc(N)cc1S(=O)(=O)C(F)(F)F,,CCO,,Cl,,val
US20150329548A1,C[C@@H]1CC[C@@H](Cn2ccc3nc(C#N)nc(-c4cccc(Cl)c4)c32)CC1.NO>>C[C@@H]1CC[C@@H](Cn2ccc3nc(C(N)=NO)nc(-c4cccc(Cl)c4)c32)CC1,,CCO,O,Cl,O=C([O-])O.[Na+],val
US20030065191A1,CN1COCN(Cc2cnc(SC3CCCCC3)s2)C1=N[N+](=O)[O-].ClCl>>CN1COCN(Cc2cnc(Cl)s2)C1=N[N+](=O)[O-],,Clc1ccccc1,,Cl,,val
US04990517,CCOC=C(C(=O)OCC)C(=O)c1c(F)cc(Cl)c(F)c1Cl.NC1CC1>>CCOC(=O)C(=CNC1CC1)C(=O)c1c(F)cc(Cl)c(F)c1Cl,,CCO,,O,,val
US20100074842A1,COC(=O)c1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(C(=O)OC)c1C(=O)OC>>OCc1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(CO)c1CO,,C1CCOC1,CCOCC,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050059650A1,CS(=O)(=O)c1ccc(-n2ncc3c(Cl)ncnc32)cc1.O=C(c1cccc(F)c1)N1CCC(O)CC1>>CS(=O)(=O)c1ccc(-n2ncc3c(OC4CCN(C(=O)c5cccc(F)c5)CC4)ncnc32)cc1,,C1CCOC1,,[H-].[Na+],,val
US20150182507A1,CS(=O)(=O)Cl.Nc1cccc(O)c1>>CS(=O)(=O)Nc1cccc(O)c1,,c1ccncc1,,,,val
US20100240702A1,COC(=O)CCn1c(=O)n(Cc2cccc3ccccc23)c2ccccc21>>O=C(O)CCn1c(=O)n(Cc2cccc3ccccc23)c2ccccc21,,CO,O,Cl,[Li+].[OH-],val
US20140045872A1,Cc1ccncc1I.O=C1NCCc2ccc(C(F)(F)F)c(F)c21>>Cc1ccncc1N1CCc2ccc(C(F)(F)F)c(F)c2C1=O,[Cu]I,C1COCCO1,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US05948792,C/C(=C/CCOS(=O)(=O)c1ccc(C)cc1)C(F)(F)F.O=C(NC1CCNCC1)C(c1ccccc1)C1CCCC1>>C/C(=C/CCN1CCC(NC(=O)C(O)(c2ccccc2)C2CCCC2)CC1)C(F)(F)F,,CCOCC,CN(C)C=O,[I-].[K+],,val
US20120232051A1,CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1Br.OB(O)c1ccc(F)cc1OCc1ccccc1>>CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1-c1ccc(F)cc1OCc1ccccc1,,CN(C)C=O,,,,val
US20030176478A1,CC(C)[Si](Cl)(C(C)C)C(C)C.Oc1cccc(Br)c1>>CC(C)[Si](Oc1cccc(Br)c1)(C(C)C)C(C)C,,CN(C)C=O,,c1c[nH]cn1,,val
US20060264415A1,CC(C)(C)OC(=O)N1CCC(CCCCO)C1.II>>CC(C)(C)OC(=O)N1CCC(CCCCI)C1,,ClCCl,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110065691A1,CCOC(=O)CC(=O)N1CCN(c2ccc(OC)c(OC3CCCC3)c2)C[C@@H]1Cc1ccccc1>>COc1ccc(N2CCN(CCC(=O)O)[C@@H](Cc3ccccc3)C2)cc1OC1CCCC1,,C1CCOC1,O,[Li+].[OH-],,val
US07399759B2,CC(O)[Si](C)(C)C.O=C(O)CCCCc1ccccn1>>C[Si](C)(C)CCOC(=O)CCCCc1ccccn1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20130137865A1,Cn1ncc(-c2nc(-c3ccc(S(=O)(=O)OCC(C)(C)C)cc3)no2)c1CCc1ccc(C(F)(F)F)cc1>>Cn1ncc(-c2nc(-c3ccc(S(=O)(=O)O)cc3)no2)c1CCc1ccc(C(F)(F)F)cc1,,C1CCOC1,,Br,CC(=O)O,val
US20040171845A1,CC(C)(C)OC(=O)N1CCC[C@H]1CI>>C[C@@H]1CCCN1C(=O)OC(C)(C)C,[Pd],CO,,CCN(CC)CC,[H][H],val
US20150126522A1,CCC(C)I.COC(=O)c1cc(Cl)cc(N)c1Cl>>CCC(C)Nc1cc(Cl)cc(C(=O)OC)c1Cl,,CCOC(C)=O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20080167356A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1CO.COC(=O)c1cccc2cc(-c3ccc(O)cc3Cl)ccc12>>COC(=O)c1cccc2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)cc3Cl)ccc12,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130281438A1,CCI.COc1c([N+](=O)[O-])ccc2c1CCCC(=O)N2>>CCN1C(=O)CCCc2c1ccc([N+](=O)[O-])c2OC,,CN(C)C=O,,[H-].[Na+],,val
US20050222201A1,Cc1ccc2[nH]c(C)cc2c1.N#Cc1cccc2c(Cl)ccnc12>>Cc1ccc2[nH]c(C)c(-c3ccc4cccc(C#N)c4n3)c2c1,,C1COCCO1,,Cl,,val
US20070032530A1,Cc1nc(-c2cccc(C(F)(F)F)c2)ccc1CCl.Oc1ccc(CCCCn2ccnn2)cc1>>Cc1nc(-c2cccc(C(F)(F)F)c2)ccc1COc1ccc(CCCCn2ccnn2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20100216814A1,CC1(c2ccncc2)CO1.CN1CCc2[nH]c3c(Cl)cccc3c2C1>>CN1CCc2c(c3cccc(Cl)c3n2CC(C)(O)c2ccncc2)C1,,CN(C)C=O,,[H-].[Na+],,val
US06046227,CC(C)(N)CCc1ccc(O)cc1.Cl.N#Cc1ccc(F)cc1>>CC(C)(N)CCc1ccc(Oc2ccc(C#N)cc2)cc1.Cl,,CC(=O)N(C)C,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20070281917A1,ClCCOCCl.N#CC1CCN(C(=O)OCc2ccccc2)CC1>>N#CC1(COCCCl)CCN(C(=O)OCc2ccccc2)CC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20070167443A1,COc1ccc(C(=O)c2c[nH]c3ccc(C)nc3c2=O)cc1C.ClCc1cccc(Cl)c1>>COc1ccc(C(=O)c2cn(Cc3cccc(Cl)c3)c3ccc(C)nc3c2=O)cc1C,,CN(C)C=O,,,,val
US20110076292A1,Cc1nc(-c2ccc3c(c2)OCCn2cc(-c4ncnn4C(C)C)nc2-3)cn1CC(C)(C)O[Si](C)(C)C(C)(C)C>>Cc1nc(-c2ccc3c(c2)OCCn2cc(-c4ncnn4C(C)C)nc2-3)cn1CC(C)(C)O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110009381A1,Nc1ccccc1-c1nc2cccnc2s1.O=C(Cl)c1cc(Cl)nc(-c2ccccc2)n1>>O=C(Nc1ccccc1-c1nc2cccnc2s1)c1cc(Cl)nc(-c2ccccc2)n1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20140155407A1,CC(N)CN.O=CC(=O)c1ccccc1>>Cc1cnc(-c2ccccc2)cn1,,CCO,,O,[K+].[OH-],val
US20100197668A1,CCCC(CCC)NCCn1cccc1C(=O)OCC>>CCCC(CCC)N1CCn2cccc2C1=O,,Cc1ccccc1,,C[Al](C)C,,val
US20090005436A1,BrCc1ccccc1.CN(C)C(=O)Cc1cc(=O)oc2cc(O)ccc12>>CN(C)C(=O)Cc1cc(=O)oc2cc(OCc3ccccc3)ccc12,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20110207736A1,C=CC(=O)Cl.COc1cc(N2CCN(C)CC2)ccc1Nc1nc(Oc2cccc(N)c2)c2ccccc2n1>>C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc3ccccc23)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130040930A1,CCOC(=O)c1ccc(NC(=O)NCCCCl)cc1>>CCOC(=O)c1ccc(N2CCCNC2=O)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20130157998A1,Cc1nnc(Cc2cccc(CC(=O)O)c2)o1.Nc1ccc(CCCCc2nnc(NC(=O)Cc3ccccc3)s2)nn1>>Cc1nnc(Cc2cccc(CC(=O)Nc3ccc(CCCCc4nnc(NC(=O)Cc5ccccc5)s4)nn3)c2)o1,,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20120083513A1,C#CCn1nnc2c(-c3ncc(-c4cccs4)[nH]3)ncn2c1=O.CI>>C#CCn1nnc2c(-c3nc(-c4cccs4)cn3C)ncn2c1=O,,CN(C)C=O,,[H-].[Na+],,val
US04365066,CCCCCCCCCCCCCCCCOc1ccc(-c2nc(CC(=O)OCC)c(OCC)o2)cc1>>CCCCCCCCCCCCCCCCOc1ccc(-c2nc(CC(=O)O)c(OCC)o2)cc1,,CO,O,[Na+].[OH-],,val
US20150336935A1,COc1cc(OC)cc(C(=O)[C@H]2[C@H](C)[C@H](NC(=O)N3CCN(C)CC3)C[C@H]3C(C)(C)CCC[C@]23C)c1>>C[C@@H]1[C@H](NC(=O)N2CCN(C)CC2)C[C@H]2C(C)(C)CCC[C@]2(C)[C@H]1C(=O)c1cc(O)cc(O)c1,,ClCCl,,BrB(Br)Br,CO,val
US20150087646A1,COC(=O)c1ccc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)cc1OC.Nc1nc2ccccc2[nH]1>>COc1cc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)ccc1C(=O)Nc1nc2ccccc2[nH]1,,Cc1ccccc1,,C[Al](C)C,,val
US20060173006A1,CCOC(CN)OCC.Cc1ccc(C(=O)O)cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1>>CCOC(CNC(=O)c1ccc(C)c(-c2ccc(NC(=O)c3c(F)cccc3F)cc2)c1)OCC,,CN(C)C=O,O,CCN=C=NCCCN(C)C,,val
US20090311318A1,CC(=O)OC(C)=O.O=C(O)C(O)c1ccccc1>>CC(=O)O[C@H](C(=O)O)c1ccccc1,CN(C)c1ccncc1,CCOC(C)=O,,CCOCC,,val
US20160218303A1,Cc1cc(N)cc(C)c1C.N#Cc1cccc(F)c1[N+](=O)[O-]>>Cc1cc(Nc2cccc(C#N)c2[N+](=O)[O-])cc(C)c1C,,O,,C1CCOC1,[H-].[Na+],val
US20160009744A1,CNCc1ccc(Cl)cc1C(O)c1csc(CO[Si](C)(C)C(C)(C)C)c1>>CN1Cc2ccc(Cl)cc2C1c1csc(CO[Si](C)(C)C(C)(C)C)c1,,ClCCl,,CCN(C(C)C)C(C)C,CS(=O)(=O)Cl,val
US20120022045A1,OC1CCC(COCc2ccccc2)OC1>>O=C1CCC(COCc2ccccc2)OC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20100249418A1,CC(C)(C)[Si](OCCBr)(c1ccccc1)c1ccccc1.Cc1c(-c2ccc(O)cc2)nc2ccc(I)cn12>>Cc1c(-c2ccc(OCCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc2)nc2ccc(I)cn12,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20070225272A1,COc1ccc(CNc2ncccc2C#N)c(OC)c1>>COc1ccc(C=Nc2ncccc2CN)c(OC)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140256700A1,C1COCCN1.Cc1noc(C)c1-c1cc(C#N)c2c3ccc(C(=O)O)cc3n(Cc3ccccc3)c2c1>>Cc1noc(C)c1-c1cc(C#N)c2c3ccc(C(=O)N4CCOCC4)cc3n(Cc3ccccc3)c2c1,,CN(C)C=O,O,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20130023541A1,Brc1ccccc1.O=Cc1cccc(Br)c1>>OC(c1ccccc1)c1cccc(Br)c1,II,C1CCOC1,,,,val
US06316467B1,CNC.O=C1CCC(c2ccccc2)O1>>CN(C)C(=O)CCC(O)c1ccccc1,,C1CCOC1,,,,val
US20110201593A1,N[C@@H]1CCC[C@@H](O)C1.O=[N+]([O-])c1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1Cl>>O=[N+]([O-])c1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1N[C@@H]1CCC[C@@H](O)C1,,CC(C)O,,,,val
US06329381B1,BrCC1OCCO1.Nc1nc(S)nc2c1nc(O)n2Cc1ccccc1>>Nc1nc(SCC2OCCO2)nc2c1nc(O)n2Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100041642A1,CC(C)(C)c1nc(C(=O)O)c(N)s1.O=C(Cl)OCC(Cl)(Cl)Cl>>CC(C)(C)c1nc(C(=O)O)c(NC(=O)OCC(Cl)(Cl)Cl)s1,,C1CCOC1,,,,val
US20100009969A1,C[C@@H]1CCCN1CCCOc1ccc(-c2nc3c(s2)CNCC3)cc1.NC(=O)CBr>>C[C@@H]1CCCN1CCCOc1ccc(-c2nc3c(s2)CN(CC(N)=O)CC3)cc1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20070054916A1,Cc1ccc(N)cc1-c1ccc2nc(N)ncc2c1.O=C=NCc1ccccc1>>Cc1ccc(NC(=O)NCc2ccccc2)cc1-c1ccc2nc(N)ncc2c1,,c1ccccc1,,,,val
US20140206663A1,COC(=O)CS.Nc1cc([N+](=O)[O-])ccc1Cl>>O=C1CSc2ccc([N+](=O)[O-])cc2N1,,CCO,O,[Na+].[OH-],,val
US20140179680A1,CCI.C[C@@H]1CC[C@@H](Cn2c(C(O)C3CCCC3)nc3cc(C#N)nc(-c4cncc(Cl)c4)c32)CC1>>CCOC(c1nc2cc(C#N)nc(-c3cncc(Cl)c3)c2n1C[C@@H]1CC[C@@H](C)CC1)C1CCCC1,,C1CCOC1,,[H-].[Na+],,val
US20060004043A1,O=P(Cl)(Cl)Cl.O=c1ccc2cc(Br)ccc2[nH]1>>Clc1ccc2cc(Br)ccc2n1,,CN(C)C=O,,,,val
US20130225619A1,CN(C)C=O.c1cnc(OCC2CCCCC2)nc1>>O=Cc1ccnc(OCC2CCCCC2)n1,,C1CCOC1,,,,val
US20080234237A1,O=C(CCCl)Nc1ccccc1F.O=[N+]([O-])O>>O=C1CCc2cc([N+](=O)[O-])cc(F)c2N1,,O,O=S(=O)(O)O,,,val
US20080085901A1,CC(=O)c1ncsc1C(F)(F)F.Nc1nccc(Cl)c1C=O>>FC(F)(F)c1scnc1-c1ccc2c(Cl)ccnc2n1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20140171422A1,CC(C)(C)[Si](C)(C)Cl.CCOC(=O)c1cnc(SC)nc1N1C[C@H](O)C[C@H]1CNS(=O)(=O)c1ccccc1[N+](=O)[O-]>>CCOC(=O)c1cnc(SC)nc1N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]1CNS(=O)(=O)c1ccccc1[N+](=O)[O-],,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US04464387,CC(C)(C)N=C=O.O=C(O)CNc1ccccc1>>CC(C)(C)N1C(=O)CN(c2ccccc2)C1=O,,Cc1ccccc1,,,,val
US20020115826A1,Brc1cccnc1.C[Sn](C)(C)Cl>>C[Sn](C)(C)c1cccnc1,,CCOCC,,[Li]CCCC,,val
US20120196864A1,O=C1CSC(=O)N1.O=Cc1ccc(OCc2ccc(C(F)(F)F)cc2C(F)(F)F)c(Cl)c1>>O=C1NC(=O)/C(=C/c2ccc(OCc3ccc(C(F)(F)F)cc3C(F)(F)F)c(Cl)c2)S1,,CCO,,C1CCNCC1,,val
US20030166639A1,CC(C)(C)OC(=O)Nc1ccc(Cl)cc1NC(=O)CC(=O)c1cccc(-c2cccnc2)c1>>O=C1CC(c2cccc(-c3cccnc3)c2)=Nc2ccc(Cl)cc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100048636A1,CCOC(=O)CO[C@@](C)(c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)N[C@@H](CC2CCCCC2)CN(C)C(=O)OCC[Si](C)(C)C)C1.CN>>CNC(=O)CO[C@@](C)(c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)N[C@@H](CC2CCCCC2)CN(C)C(=O)OCC[Si](C)(C)C)C1,,CCO,,,,val
US20120316147A1,NN1CCC(O)C1.O=C(N[C@@H](CC1CC1)C(=O)O)c1ccc(C2CC2)c(OCC2CC2)n1>>O=C(N[C@@H](CC1CC1)C(=O)NN1CCC(O)C1)c1ccc(C2CC2)c(OCC2CC2)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20100317663A1,CNC(=O)c1ccccc1Nc1cc(Cl)ncc1C(F)(F)F.Nc1ccc(N2CCOCC2)cc1>>CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2)ncc1C(F)(F)F,,C1COCCO1,,Cl,,val
US20040116460A1,Cc1onc2c1c(=O)n(C1CC(C(=O)O)CN(C(=O)OC(C)(C)C)C1)c1cccc(Cl)c21>>Cc1onc2c1c(=O)n(C1CC(CO)CN(C(=O)OC(C)(C)C)C1)c1cccc(Cl)c21,,C1CCOC1,,CSC,,val
US20070043072A1,Cc1cc(CCC(=O)O)nc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)c1.Nc1cc(I)cnc1N>>Cc1cc(CCC(=O)Nc2cc(I)cnc2N)nc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)c1,,c1ccncc1,,CCN(C(C)C)C(C)C,,val
US20150119405A1,NC(N)=O.Nc1c(Cl)cc(Br)cc1C=O>>Oc1ncc2cc(Br)cc(Cl)c2n1,,O,,,,val
US05420293,CC1(C(F)(F)F)CCC(=O)N1.COc1ccc(C(=O)Cl)cc1>>COc1ccc(C(=O)N2C(=O)CCC2(C)C(F)(F)F)cc1,,C1COCCO1,,CCN(CC)CC,,val
US20020072624A1,BrC(Br)(Br)Br.CC(C)(C)[Si](C)(C)OCCOCCO>>CC(C)(C)[Si](C)(C)OCCOCCBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20110257126A1,COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O.NCCCC[C@H](N)C(=O)O>>COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O.NCCCC[C@H](N)C(=O)O,,CO,O,,,val
US20060166987A1,NC(=O)c1ccc(Oc2ccc(C=O)cc2)s1.NCCC1CCOCC1>>NC(=O)c1ccc(Oc2ccc(CNCCC3CCOCC3)cc2)s1,,CO,,[BH4-].[Na+],,val
US20070123505A1,CCOC(=O)c1cc(F)cc(C(C2CNC2)C(C)(C)F)c1.N#Cc1cccc(C(Br)c2ccc(Cl)cc2)c1>>CCOC(=O)c1cc(F)cc(C(C2CN(C(c3ccc(Cl)cc3)c3cccc(C#N)c3)C2)C(C)(C)F)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US03963734,Nc1ncc(Cl)cc1[N+](=O)[O-].O=C(OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>On1c(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)nc2ncc(Cl)cc21,,c1ccncc1,,,,val
US20090176823A1,CC(C)(C)OC(=O)N(Cc1ccc(Cl)c(CO)c1)CC(F)F>>CC(C)(C)OC(=O)N(Cc1ccc(Cl)c(C=O)c1)CC(F)F,O=[Mn]=O,CC#N,,,,val
US20120264748A1,Cc1ccc(-n2nccn2)c(CO)c1.O=S(Cl)Cl>>Cc1ccc(-n2nccn2)c(CCl)c1,,ClC(Cl)Cl,,,,val
US06124283,CN1CCN(c2cccc3c2C[C@H](N)CC3)CC1.O=C(O)c1ccc(C2CCCCC2)cc1>>CN1CCN(c2cccc3c2C[C@H](NC(=O)c2ccc(C4CCCCC4)cc2)CC3)CC1,,ClCCl,O=S(Cl)Cl,CCN(CC)CC,,val
US06413974B1,Clc1nc(Cl)c2ncn(C3CCCC3)c2n1.NCC1CCCCC1>>Clc1nc(NCC2CCCCC2)c2ncn(C3CCCC3)c2n1,,CCN(CC)CC,,,,val
US20150291572A1,COC(=O)c1cc(=O)cco1>>COC(=O)C1CC(O)CCO1,[Pd],CO,,,,val
US20070249580A1,COC(=O)c1cccc(N2CCCC(NC(=O)OC(C)(C)C)C2)c1>>COC(=O)c1cccc(N2CCCC(N)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US03997536,CCOC(CC#N)OCC.CCOC=O.[Na]>>CCOC(OCC)C(C#N)=CO.[Na],,CCOCC,,,,val
US04254141,CSC(=NO)C(=O)N(C)C.CSC(C)=NOC(=O)N(C)SN(C)C(=O)ON=C(C)C(C)=NOC(=O)N(C)SN(C)C(=O)F>>CSC(C)=NOC(=O)N(C)SN(C)C(=O)ON=C(C)C(C)=NOC(=O)N(C)SN(C)C(=O)ON=C(SC)C(=O)N(C)C,,ClCCl,,CCN(CC)CC,,val
US20050182025A1,CCOC=NC#N.CSc1cc(OCCC[Si](C)(C)C)c(Cl)cc1N>>CSc1cc(OCCC[Si](C)(C)C)c(Cl)cc1NC=NC#N,,CCO,,,,val
US20060276450A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.COc1ccc2c(=O)[nH]c(C)c(-c3ccccc3)c2c1>>COc1ccc2c(=S)[nH]c(C)c(-c3ccccc3)c2c1,,Cc1ccccc1,,CO,ClCCl,val
US20030130506A1,C=CC(C)(C)C(NC(=O)OC(C)(C)C)C(=O)OC>>C=CC(C)(C)C(N)C(=O)OC,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070244159A1,CC(C)(C)C1Cc2cc(NC(=O)C3(c4ccc5c(c4)OCO5)CC3)c(F)cc2N1.O=CC1CCCOC1>>CC(C)(C)C1Cc2cc(NC(=O)C3(c4ccc5c(c4)OCO5)CC3)c(F)cc2N1CC1CCCOC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20030078248A1,CC(=O)Cl.Cc1ccsc1C>>CC(=O)c1cc(C)c(C)s1,,c1ccccc1,,Cl[Sn](Cl)(Cl)Cl,,val
US20070032470A1,CC(=O)c1cc(S(C)(=O)=O)cc(C(=O)O)c1C.COc1cccc(CN(C[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)C(=O)OC(C)(C)C)c1>>COc1cccc(CN(C[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(C(C)=O)cc(S(C)(=O)=O)c2)C(=O)OC(C)(C)C)c1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100305133A1,CCOC(=O)CNC(=O)c1c(O)ccc2nc(-c3ccccc3)c(-c3ccccc3)nc12>>O=C(O)CNC(=O)c1c(O)ccc2nc(-c3ccccc3)c(-c3ccccc3)nc12,,C1CCOC1,CO,[Na+].[OH-],,val
US20070082853A1,O=C(OCc1ccccc1)C(Cc1ccccc1)ON1C(=O)c2ccccc2C1=O>>NOC(Cc1ccccc1)C(=O)OCc1ccccc1,,CCO,CCOC(C)=O,NN,O,val
US20050070585A1,CCc1oc2ccccc2c1C(=O)c1ccccc1>>CCc1oc2ccccc2c1C(O)c1ccccc1,,CCO,,[BH4-].[Na+],,val
US20050085508A1,Cc1ccc(N(C(=O)c2ccco2)C2CCN(CCC3(CCNC(=O)OC(C)(C)C)CCCCC3)CC2)cc1>>Cc1ccc(N(C(=O)c2ccco2)C2CCN(CCC3(CCN)CCCCC3)CC2)cc1,,CO,,C1COCCO1,Cl,val
US04496572,Cc1cc2cc(C#N)ccc2o1.O=S(=O)(Cl)Cl>>Cc1oc2ccc(C#N)cc2c1Cl,,ClC(Cl)Cl,,,,val
US20100331293A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.Cc1c(Cl)nc2c(Cl)c(F)ccc2c1Cl>>Cc1c(-c2ccccn2)nc2c(Cl)c(F)ccc2c1Cl,,Cc1ccccc1,,,,val
US20110071126A1,O=C1c2cc(Br)ccc2OC12CCc1ccccc1CC2.OB(O)c1cc(F)cc(Cl)c1>>O=C1c2cc(-c3cc(F)cc(Cl)c3)ccc2OC12CCc1ccccc1CC2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,ClCCl,O,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US20050239865A1,CC(C)C=O.CCC(CC)C(=O)Nc1sc2c(c1C#N)CCCN2>>CCC(CC)C(=O)Nc1sc2c(c1C#N)CCCN2CC(C)C,,ClCCl,,CC(=O)O,[Na],val
US20090181964A1,CC(=O)OC(C)=O.NS(=O)(=O)c1cccc(C(=O)C(C(=O)c2cc(F)cc(F)c2)=C2Nc3ccccc3N2)c1>>CC(=O)NS(=O)(=O)c1cccc(C(=O)C(C(=O)c2cc(F)cc(F)c2)=C2Nc3ccccc3N2)c1,,CN(C)C=O,,c1ccncc1,,val
US20120295874A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1ccc(CNC(=O)N2CCN(C(=O)CNC(=O)OCc3ccccc3)CC2)cc1>>CC(C)(C)OC(=O)NCc1ccc(CNC(=O)N2CCN(C(=O)CNC(=O)OCc3ccccc3)CC2)cc1,,ClCCl,,CCN(CC)CC,,val
US20150353553A1,COC(=O)c1nc(N[C@H](C)C2CC2)c2c(n1)nc(-c1cccc(C)c1)n2Cc1ccc(F)c(C(F)(F)F)c1>>Cc1cccc(-c2nc3nc(C(=O)O)nc(N[C@H](C)C4CC4)c3n2Cc2ccc(F)c(C(F)(F)F)c2)c1,,C1CCOC1,,[Li+].[OH-],,val
US20150291563A1,CC(C)(C)OC(=O)N1CC=C(c2ccc(C3CC(C(O)(C(F)(F)F)C(F)(F)F)=NN3c3ccccc3Cl)cn2)CC1.Cl>>Cl.OC(C1=NN(c2ccccc2Cl)C(c2ccc(C3=CCNCC3)nc2)C1)(C(F)(F)F)C(F)(F)F,,CCOC(C)=O,,,,val
US04124639,CCc1ccc([N+](=O)[O-])cc1CCl>>CCc1ccc(N)cc1C,[Pd],CC(=O)O,,[H][H],,val
US05436361,C#CCCCCC#C.C1CCOC1.C=O>>OCC#CCCCCC#CCO,,CCOCC,,Cl,[Li]CCCC,val
US20090012093A1,CC(C)(C)OC(=O)CCc1ccc(OCc2cccc(-c3ccccc3C=O)c2)cc1>>CC(C)(C)OC(=O)CCc1ccc(OCc2cccc(-c3ccccc3CO)c2)cc1,,C1CCOC1,CO,[BH4-].[Na+],,val
US20030092911A1,ClCCl.O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1>>Cl.Cl.O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1,,ClCCl,,,,val
US20010034352A1,CC(C)(C)OC(=O)NC1CCNCC1.O=CCc1coc2ccccc12>>CC(C)(C)OC(=O)NC1CCN(CCc2coc3ccccc23)CC1,,CC(=O)O,ClCCl,[Na+].[OH-],,val
US20120115856A1,CC(C)(C)CN.O=[N+]([O-])c1cc(-c2nc3ccccc3o2)ccc1F>>CC(C)(C)CNc1ccc(-c2nc3ccccc3o2)cc1[N+](=O)[O-],,CCO,,O,O=C([O-])[O-].[K+].[K+],val
US20070208020A1,CSc1nc(N)nc(SCC(=O)Nc2cc(C(F)(F)F)ccc2N)c1C#N>>CSc1nc(N)nc(SCc2nc3ccc(C(F)(F)F)cc3[nH]2)c1C#N,,CC(=O)O,,,,val
US20100048561A1,CC(C)(C)OC(=O)N1CCC(O)CC1.CCSc1ncc2ccc(O)cc2n1>>CCSc1ncc2ccc(OC3CCN(C(=O)OC(C)(C)C)CC3)cc2n1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150353581A1,Cc1cc(OCC(C)(N)C#N)c(Cl)c2c1COB2O.O=C(O)c1ccc(OC(F)(F)F)cc1>>Cc1cc(OCC(C)(C#N)NC(=O)c2ccc(OC(F)(F)F)cc2)c(Cl)c2c1COB2O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05025031,O=C=NS(=O)(=O)Cl.Oc1ccc(C(F)(F)F)cc1>>NS(=O)(=O)Oc1ccc(C(F)(F)F)cc1,,c1ccccc1,,Cc1ccccc1,,val
US04045467,CCCCC(C)C(O)C=CC1CC(OC2CCCCO2)C(O)C1CCCCCCC(=O)O>>CCCCC(C)C(O)C=CC1CC(O)C(O)C1CCCCCCC(=O)O,,O,,CC(=O)O,,val
US08889854B2,C=C(C)[C@@H]1CC[C@]2(NCCN3C[C@@H]4C[C@H]3CS4(=O)=O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(=O)CC(C)(C)C(=O)OC(C)(C)C)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(NCCN3C[C@@H]4C[C@H]3CS4(=O)=O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(=O)CC(C)(C)C(=O)O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,ClCCCl,ClCCl,CO,O=C(O)C(F)(F)F,val
US20080085904A1,COc1cc(OC)c(-c2ccnn2-c2ccccc2Cl)cc1C=Cc1ccncc1>>COc1cc(OC)c(-c2ccnn2-c2ccccc2Cl)cc1CCc1ccncc1,[Pt],CCOCC,,,,val
US20080125413A1,O=C1CCC(=O)N1Br.O=C1CN=C(c2ccccc2)c2ccccc2N1CC(F)(F)F>>O=C1C(O)N=C(c2ccccc2)c2ccccc2N1CC(F)(F)F,,ClC(Cl)(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20150051410A1,CC(C)I.O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1>>CC(C)OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20160074852A1,CC(C)(C)[Si](C)(C)OCCCC[C@]1(C)CCCC(=O)C1>>C[C@]1(CCCCO)CCCC(=O)C1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20160068510A1,CCOP(=O)(OCC)C(F)(F)C(C)(O)c1ccnc(O[C@@H]2CC[C@@H](C)N(C(=O)c3ccccc3-n3nccn3)C2)c1>>C[C@@H]1CC[C@@H](Oc2cc(C(C)(O)C(F)F)ccn2)CN1C(=O)c1ccccc1-n1nccn1,,C1CCOC1,,CO,C[O-].[Na+],val
US20120202785A1,NC1CCOCC1.O=[N+]([O-])c1ccccc1F>>O=[N+]([O-])c1ccccc1NC1CCOCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070185184A1,CC(=O)c1cn(-c2ccc(N)cc2Cl)c2cc(Cl)ccc12.N#C[O-]>>CC(=O)c1cn(-c2ccc(NC(N)=O)cc2Cl)c2cc(Cl)ccc12,,O,,CC(=O)O,,val
US20020169317A1,ClCCBr.Oc1cccc2c1c1cccc3c1n2[C@H](c1ccccc1)CO3>>ClCCOc1cccc2c1c1cccc3c1n2[C@H](c1ccccc1)CO3,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04622405,COc1ccc2c(c1OC)CC1C(=O)N(Cc3ccccc3)C(=O)C21.Cl>>COc1ccc2c(c1OC)CC1CN(Cc3ccccc3)CC21.Cl,,C1CCOC1,,O,,val
US20110207701A1,O=[N+]([O-])c1cccc2c1B(O)OC2>>Nc1cccc2c1B(O)OC2,[Pd],CO,,,,val
US20120202785A1,C[C@H](NC(=O)OC(C)(C)C)c1nc2cccc(F)c2n1-c1ccccc1>>C[C@H](N)c1nc2cccc(F)c2n1-c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160159816A1,CC(C)OC(=O)Cl.NCC1CCc2c(sc3ncnc(Nc4ccc5[nH]ncc5c4)c23)C1>>CC(C)OC(=O)NCC1CCc2c(sc3ncnc(Nc4ccc5[nH]ncc5c4)c23)C1,,O,,C1CCOC1,CCN(CC)CC,val
US04159979,CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)OC(C)(C)C>>CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)OC(C)(C)C,[Pd],CCO,,,,val
US04491585,CC1(C)[C@@H](C(=O)Cl)[C@@H]1/C=C(\Cl)c1ccc(Cl)cc1.OCc1cccc(Oc2ccccc2)n1>>CC1(C)[C@@H](C(=O)OCc2cccc(Oc3ccccc3)n2)[C@@H]1/C=C(\Cl)c1ccc(Cl)cc1,,Cc1ccccc1,,O,c1ccncc1,val
US05998433,CS(=O)(=O)OCCc1ccoc1.O=C1NC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1CCc1ccoc1,,CN(C)C=O,,O,[K],val
US06420397B1,CON(C)C(=O)[C@H](CCONC=NNC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1>>CON(C)C(=O)[C@@H](N)CCONC=NNC(=O)OC(C)(C)C,[Pd],CO,,ClC(Cl)Cl,,val
US20090118275A1,CS(=O)(=O)N1CCNCC1.CS(=O)(=O)c1nc2nc(Cl)nc(N3CCOCC3)c2s1>>CS(=O)(=O)N1CCN(c2nc3nc(Cl)nc(N4CCOCC4)c3s2)CC1,,ClCCCl,,CC(=O)[O-].[Na+],,val
US20150105366A1,COc1nc2ccc(Br)cc2c(Cl)c1Cc1ccc(-n2cccn2)cc1.Cc1ncc(C=O)n1C>>COc1nc2ccc(C(O)c3cnc(C)n3C)cc2c(Cl)c1Cc1ccc(-n2cccn2)cc1,,C1CCOC1,,O,[Li]CCCC,val
US20090298836A1,CC(C)(C)OC(=O)N[C@H](CN(C(=O)OC(C)(C)C)c1nnc(-c2ccc([N+](=O)[O-])c(F)c2)s1)[C@@H](O[Si](C)(C)C(C)(C)C)c1ccc(C(F)(F)F)cc1.CCOC(=O)CC(=O)OCC>>CCOC(=O)C(C(=O)OCC)c1cc(-c2nnc(N(C[C@@H](NC(=O)OC(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)c3ccc(C(F)(F)F)cc3)C(=O)OC(C)(C)C)s2)ccc1[N+](=O)[O-],,C1COCCO1,,[H-].[Na+],,val
US20020146684A1,CCC(C)N.CCOC(=O)CBr>>CCOC(=O)CNC(C)CC,,C1CCOC1,C1CCOC1,,,val
US20060106029A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(O)c1cccc(Cl)c1F>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cccc(Cl)c2F)CC1,,ClC(Cl)Cl,,On1nnc2ccccc21,,val
US20060135491A1,COC(=O)C1=C(O)CC2(C=CCCC2)CC1>>O=C1CCCC2(C=CCCC2)C1,,CS(C)=O,,O,[Cl-].[Na+],val
US20110183954A1,CCn1cncc1N.Clc1nc(Cl)nc(Cl)n1>>CCn1cnc(Nc2nc(Cl)nc(Cl)n2)c1,,CCO,,CCN(CC)CC,,val
US20110212103A1,CC(C)(C)OC(=O)NCCCN.COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C(=O)O)c2c1C>>COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C(=O)NCCCNC(=O)OC(C)(C)C)c2c1C,,CC#N,O,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20070219203A1,FC(F)(F)c1cccnc1-c1ccc2c(Cl)nc(CCl)nc2c1.NCCc1ccccc1>>FC(F)(F)c1cccnc1-c1ccc2c(NCCc3ccccc3)nc(CCl)nc2c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20130324516A1,CN1CCC(CN)CC1.Nc1ncnc2ccc(-c3cccc(C(=O)O)c3)nc12>>CN1CCC(CNC(=O)c2cccc(-c3ccc4ncnc(N)c4n3)c2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060122394A1,CCOC(=O)c1cnc(Cl)c(Cl)c1.C[C@@H]1CNCCN1>>CCOC(=O)c1cnc(N2CCN[C@H](C)C2)c(Cl)c1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20080280917A1,COc1ccc2c(OCCn3nc(-c4ccc(C(=O)NCCN)c(Cl)c4)ccc3=O)ccnc2c1>>COc1ccc2c(OCCn3nc(-c4ccc(C5=NCCN5)c(Cl)c4)ccc3=O)ccnc2c1,,ClCCl,,C[Si](C)(C)Cl,[I-].[Na+],val
US20110071141A1,FC(F)(F)C1(c2cc(Cl)cc(Cl)c2)CC(c2ccc3c(c2)CCC3N2Cc3ccccc3C2)=NO1>>NC1CCc2cc(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)ccc21,,CCO,,NN,O,val
US06534546B1,Cc1cc(CC#N)ccc1NC(=O)OC(C)(C)C>>Cc1cc(CC#N)ccc1N,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US06133294,CC(C)(C)C(=O)Cl.CSc1ncc(C(=N)NO)cc1Cl>>CSc1ncc(-c2noc(C(C)(C)C)n2)cc1Cl,,Cc1ccccc1,,,,val
US07465808B2,Cc1ccccc1.O=C(O)CCc1cc(-c2ccc(Cl)c(Cl)c2)n(-c2ccc(Cl)cc2Cl)n1>>CC(C)(C)OC(=O)CCc1cc(-c2ccc(Cl)c(Cl)c2)n(-c2ccc(Cl)cc2Cl)n1,,Cc1ccccc1,,,,val
US20070238737A1,Cc1ccc(B(O)O)o1.O=S(=O)(Nc1ccnc(Cl)c1)c1ccc(Br)cc1>>Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(Cl)c3)cc2)o1,,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20080255083A1,CS(=O)(=O)OCc1ccco1.O=c1cc(O)ccn1CCc1ccc(CO)cc1>>O=c1cc(OCc2ccco2)ccn1CCc1ccc(CO)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150344466A1,CCOC(=O)c1cc(Cc2ccccc2OC)on1>>COc1ccccc1Cc1cc(C(=O)O)no1,,O,,CCO,[Na+].[OH-],val
US20080200463A1,CC(=O)Nc1nc(C)c(-c2ccc(S(=O)(=O)Cl)s2)s1.NCCO>>CC(=O)Nc1nc(C)c(-c2ccc(S(=O)(=O)NCCO)s2)s1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130018034A1,CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(-c3ccnc4[nH]ccc34)cn2)C1.O=C(O)C(F)(F)F>>N#CCC1(n2cc(-c3ccnc4[nH]ccc34)cn2)CNC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20130011352A1,COC(=O)Cl.COc1cc(C)ccc1O>>COC(=O)Oc1ccc(C)cc1OC,CN(C)c1ccncc1,ClCCl,,Cl,c1ccncc1,val
US20120165310A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1(C)SCCNC1=O>>CC(C)(C)OC(=O)N1CCSC(C)(C)C1,,C1CCOC1,,B,CSC,val
US20160031838A1,CCOC(=O)/C=C/c1ccccn1>>CCOC(=O)CCc1ccccn1,[Pd],CCO,,CCOC(C)=O,,val
US20080021032A1,CN(C)C(=O)CCn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)n1.CO.O>>COc1cc([C@@H](CC2CCCC2)C(=O)O)ccc1S(C)(=O)=O,,CS(C)=O,,[Na],,val
US20080214448A1,CCO.CCOC(=O)CCCCCCC#N>>CCOC(=N)CCCCCCC(=O)OCC,,CCOCC,,Cl,,val
US08383644B2,COC(=O)[C@H](Cc1ccc(-c2ccnc(C)c2C)cc1)NC(=O)[C@@H]1Cc2cc3c(cc2CN1)O[C@@H](c1cccc(OCc2ccc(Cl)c(Cl)c2)c1)CO3.C[C@@H](N=C=O)c1ccccc1>>Cc1nccc(-c2ccc(C[C@H](NC(=O)[C@@H]3Cc4cc5c(cc4CN3C(=O)N[C@H](C)c3ccccc3)O[C@@H](c3cccc(OCc4ccc(Cl)c(Cl)c4)c3)CO5)C(=O)O)cc2)c1C,,ClCCl,,CO,,val
US20140323468A1,CC(C)(C)OC(=O)N1CCCc2cc(-c3cncc(C=CCS(C)(=O)=O)c3)cnc21>>CC(C)(C)OC(=O)N1CCCc2cc(-c3cncc(CCCS(C)(=O)=O)c3)cnc21,[Pd],CO,,,,val
US04309435,COc1c(NCCSCc2csc(NC(=N)N)n2)c(=O)c1=O.NCc1ccncc1>>N=C(N)Nc1nc(CSCCNc2c(NCc3ccncc3)c(=O)c2=O)cs1,,CN(C)C=O,,CO,,val
US04594343,N#CC(c1ccccc1)(c1ccccc1)C1CCN(Cc2ccccc2)C1.O=S(=O)(O)O>>NC(=O)C(c1ccccc1)(c1ccccc1)C1CCN(Cc2ccccc2)C1,,ClC(Cl)Cl,,[Na+].[OH-],,val
US20050245563A1,CC(C)CC(=O)Cl.Cc1n[nH]c2c1c(=O)n(CCCN)c1ccccc21>>Cc1[nH]nc2c1c(=O)n(CCCNC(=O)CC(C)C)c1ccccc21,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US05594081,COC(=O)C(Cc1ccccc1Br)C(=O)OC>>COC(=O)CCc1ccccc1Br,,CS(C)=O,O,[Cl-].[Li+],,val
US05084083,BrBr.O=C(O)Cc1csc(-c2ccc(Cl)cc2)n1>>O=C(O)Cc1nc(-c2ccc(Cl)cc2)sc1Br,,CC(=O)O,,,,val
US20070219210A1,CCCC[Sn](C#N)(CCCC)CCCC.CCOC(=O)c1cc(-c2ccc(OS(=O)(=O)C(F)(F)F)cn2)n(-c2ccc(C)nc2)n1>>CCOC(=O)c1cc(-c2ccc(C#N)cn2)n(-c2ccc(C)nc2)n1,,ClCCCl,,O=C([O-])O.[Na+],,val
US20120184542A1,CCOC(=O)CC(=O)OCC.COc1nc(C)c(C=O)c(N)n1>>CCOC(=O)c1cc2c(C)nc(OC)nc2[nH]c1=O,,CN(C)C=O,,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20100056502A1,CC(C)(C)OC(=O)N[C@H]1CCN(C(=O)OCc2ccccc2)C[C@H]1O>>N[C@H]1CCN(C(=O)OCc2ccccc2)C[C@H]1O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120322785A1,C[C@@H](N)c1ccccc1.O=C(O)C1CC1(F)Cl>>C[C@@H](NC(=O)C1CC1(F)Cl)c1ccccc1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20130150355A1,COC(=O)CBr.Cc1cc(-c2c[nH]c(C3CCCCC3)n2)ccc1F>>Cc1cc(-c2cn(CC(=O)O)c(C3CCCCC3)n2)ccc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120295924A1,C=CCc1c(C(=O)OCC)sc2c1c(=O)n(C)c(=O)n2C>>C=CCc1c(C(=O)O)sc2c1c(=O)n(C)c(=O)n2C,,CCO,,[K+].[OH-],,val
US20150353581A1,CCOc1c(OCC(C)(N)C#N)ccc2c1B(O)OC2.O=C(O)c1ccc(OC(F)(F)F)cc1>>CCOc1c(OCC(C)(C#N)NC(=O)c2ccc(OC(F)(F)F)cc2)ccc2c1B(O)OC2,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020193436A1,CCOC(=O)CC/C=C/CCc1ccc(-c2ccccc2)cc1>>O=C(O)CC/C=C/CCc1ccc(-c2ccccc2)cc1,,[Na+],[OH-],,,val
US20080287663A1,CC(=O)OC[C@H]1O[C@@H](c2ccc(-c3ccc([C@@H]4[C@@H](CC[C@H](O)c5ccc(F)cc5)C(=O)N4c4ccccc4)c(OCc4ccccc4)c3)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(-c3ccc([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cc3)cc2OCc2ccccc2)N1c1ccccc1,,CO,,[NH4+].[OH-],,val
US20030097010A1,CCc1ccc(C(=O)c2cc(C(=O)c3ccc(CC)cc3)c(C(=O)O)cc2C(=O)O)cc1>>Cc1ccc(Cc2cc(Cc3ccc(C)cc3)c(C(=O)O)cc2C(=O)O)cc1,[Pd],CC(=O)O,,[H][H],,val
US20080119518A1,COc1ccc(OC)c(C(=O)CN2CCC(n3ccc4ccc(C(N)=O)cc43)CC2)c1>>COc1ccc(OC)c(C(O)CN2CCC(n3ccc4ccc(C(N)=O)cc43)CC2)c1,,CO,ClCCl,[BH4-].[Na+],,val
US06200976B1,BrBr.O=[N+]([O-])c1cccnc1O>>Br.O=[N+]([O-])c1cc(Br)cnc1O,,ClC(Cl)(Cl)Cl,,,,val
US20040023989A1,CCCCc1[nH]nc(C(=O)O)c1[N+](=O)[O-].CN(C)C=O>>CCCCc1[nH]nc(C(N)=O)c1[N+](=O)[O-],,ClCCl,,O=C(Cl)C(=O)Cl,,val
US04886814,BrBr.CC(=O)c1nc(C)oc1C>>Cc1nc(C(=O)CBr)c(C)o1,,CC(=O)O,,Br,,val
US20120149718A1,CS(=O)(=O)c1ccc(C(Cc2ccc(F)cc2)C(=O)O)cc1.Cc1cnc(N)cn1>>Cc1cnc(NC(=O)C(Cc2ccc(F)cc2)c2ccc(S(C)(=O)=O)cc2)cn1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US05350761,NO.O=CCOc1ccc2c(c1)CCN(Cc1ccc(-c3ccc(F)cc3)cc1)C2>>O=C1c2ccc(OCC=NO)cc2CCN1Cc1ccc(-c2ccc(F)cc2)cc1,,c1ccncc1,,CCO,Cl,val
US05326773,CC(C)(C)OC(=O)N[C@H]1CCC(C)(C)OC1=O.Cl>>CC1(C)CC[C@H](N)C(=O)O1.Cl,,CCOC(C)=O,,,,val
US20100010035A1,CCOc1cc(=O)n(Cc2ccc(-c3cc(C)sc3S(=O)(=O)N(COCCOC)c3noc(C)c3C)c(C)c2)c2cc(CC)nc(CC)c12>>CCOc1cc(=O)n(Cc2ccc(-c3cc(C)sc3S(=O)(=O)Nc3noc(C)c3C)c(C)c2)c2cc(CC)nc(CC)c12,,CCO,,Cl,,val
US20100260709A1,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@]2(CN1C(=O)[C@@H](N)C(C)(C)C)C(C)(C)C21CCC1)C(=O)NS(=O)(=O)N1CCCC1.CC(C)(C)OC(=O)N[C@H](C(=O)O)C1(C)CCCCC1>>C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@]2(CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C1(C)CCCCC1)C(C)(C)C)C(C)(C)C21CCC1)C(=O)NS(=O)(=O)N1CCCC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130065861A1,CC(C)(C)OC(=O)[C@H](CS)NC(=O)OCC1c2ccccc2-c2ccccc21.CCCCCCCCCCCCOC[C@@H]1CO1>>CCCCCCCCCCCCOC[C@@H](O)CSC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)OC(C)(C)C,,CC(C)(C)O,,O=C([O-])[O-].[K+].[K+],,val
US20050010052A1,CC(C)(C)OC(=O)NCCCN.O=C(NCC12CC3CC(CC(C3)C1)C2)c1ccnc(Cl)c1Cl>>CC(C)(C)OC(=O)NCCCNc1nccc(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1Cl,,CS(C)=O,,CCOC(C)=O,,val
US06956050B2,CS(=O)(=O)Cl.OCCc1ccc(-n2cc(-c3ccccc3)nc2C(F)(F)F)cc1>>CS(=O)(=O)OCCc1ccc(-n2cc(-c3ccccc3)nc2C(F)(F)F)cc1,,ClCCl,,CCN(CC)CC,,val
US20130225552A1,CC(C)(C)OC(=O)N[C@@H]1C[C@@H](N2C(=O)C(F)(F)c3cc(F)cnc32)C1.Cl>>Cl.N[C@H]1C[C@H](N2C(=O)C(F)(F)c3cc(F)cnc32)C1,,C1COCCO1,,,,val
US05102877,C=CCOC(=O)Cl.CCOC(=O)[C@@H]1COCCN1>>C=CCOC(=O)N1CCOC[C@H]1C(=O)OCC,,C1CCOC1,O,[Na+].[OH-],,val
US20060252837A1,CCOC(=O)C(=O)CBr.NC(=O)C=Cc1ccccc1>>CCOC(=O)c1coc(/C=C/c2ccccc2)n1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20160222028A1,CC(=O)Cl.COC(=O)c1ccc2c(c1)O[C@H](C)CNC2>>COC(=O)c1ccc2c(c1)O[C@H](C)CN(C(C)=O)C2,,ClCCl,,CCN(CC)CC,,val
US20020183337A1,CC(C)Cn1c(=O)n(C)c(=O)c2c(Sc3ccc([N+](=O)[O-])cc3)c(Cc3cccc4ccccc34)sc21>>CC(C)Cn1c(=O)n(C)c(=O)c2c(Sc3ccc(N)cc3)c(Cc3cccc4ccccc34)sc21,[Fe],CCO,O,[Na+].[OH-],[Cl-].[NH4+],val
US20150299165A1,COC(=O)c1ccc(N2CC(F)(F)C2)c(OCCF)n1>>O=C(O)c1ccc(N2CC(F)(F)C2)c(OCCF)n1,,C1CCOC1,O,[Li+].[OH-],,val
US20020137689A1,CCCCCCCC(I)I.O=C1C(CCC(O)c2ccc(F)cc2)C(c2ccc(O)cc2)N1c1ccc(F)cc1>>O=C1C(CCC(O)c2ccc(F)cc2)C(c2ccc(OCCCCCCCCI)cc2)N1c1ccc(F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04532240,CCc1nc(N)nc(N)c1N1CCNCC1.N#Cc1ccc(F)cc1>>CCc1nc(N)nc(N)c1N1CCN(c2ccc(C#N)cc2)CC1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05859007,COc1ccc(N(C(=O)CN2C(=O)CC(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1.ClCOCc1ccccc1>>COc1ccc(N(C(=O)CN2C(=O)C(COCc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1,,C1CCOC1,CN(C)C=O,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20110319430A1,Cc1nn(C)c(O)c1-c1c(F)cc(F)cc1F.O=[N+]([O-])c1cc(F)c(F)c(F)c1>>Cc1nn(C)c(Oc2c(F)cc([N+](=O)[O-])cc2F)c1-c1c(F)cc(F)cc1F,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120088755A1,Cc1nc2c(Cl)c(O)ccc2[nH]1.Clc1cc(Cl)ncn1>>Cc1nc2c(Cl)c(Oc3cc(Cl)ncn3)ccc2[nH]1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20140179666A1,CCCC(F)(F)c1cnc2c(c1)NCC2(C)C.C[C@@H]1COCCN1C[C@H]1CN(C(=O)OC(C)(C)C)[C@H](C)CN1CC(=O)O>>CCCC(F)(F)c1cnc2c(c1)N(C(=O)CN1C[C@@H](C)N(C(=O)OC(C)(C)C)C[C@@H]1CN1CCOC[C@H]1C)CC2(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04150137,CC(C)Cc1ccc(C(C)C(=O)Cl)cc1.OCc1cccc(F)c1>>CC(C)Cc1ccc(C(C)C(=O)OCc2cccc(F)c2)cc1,,C1CCOC1,,CCN(CC)CC,O,val
US20160068489A1,Cc1nc(NC(=O)CCCCl)c(C)c(C)c1OCc1ccccc1>>Cc1nc(NC(=O)CCCCl)c(C)c(C)c1O,[Pd],,,CO,,val
US06699865B2,CN(C)C=C(C(=O)c1c[nH]c(C(=O)NCc2ccccc2)c1)c1ccccc1.NN>>O=C(NCc1ccccc1)c1cc(-c2n[nH]cc2-c2ccccc2)c[nH]1,,CCO,,O,,val
US20070032515A1,COCCOc1cccc(CO)c1OC.O=S(Cl)Cl>>COCCOc1cccc(CCl)c1OC,,C1CCOC1,,O,c1ccncc1,val
US20110144090A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.CCn1ccc2c(OCc3ccccc3)cc(F)cc21>>CCn1cc(C2=CCNCC2)c2c(OCc3ccccc3)cc(F)cc21,,CC(=O)O,,O=C(O)C(F)(F)F,,val
US20120202785A1,Cc1cccc(-n2c([C@H](C)N)nc3cccnc32)c1.Clc1ncnc2c1ncn2C1CCCCO1>>Cc1cccc(-n2c([C@H](C)Nc3ncnc4[nH]cnc34)nc3cccnc32)c1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20120101124A1,CC(C)Oc1ncc(-c2nc(-c3ccc(O)c4occc34)no2)cc1Cl.CCOC(=O)CBr>>CCOC(=O)COc1ccc(-c2noc(-c3cnc(OC(C)C)c(Cl)c3)n2)c2ccoc12,,C1CCOC1,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US06057369,CC(C)(C)OC(=O)CC(CCCCc1ccccc1)Sc1ccccc1>>O=C(O)CC(CCCCc1ccccc1)Sc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130217666A1,CCOC(=O)c1nc2c(s1)C(C)(O)COc1ccc(Br)cc1-2>>CCOC(=O)c1nc2c(s1)C(C)COc1ccc(Br)cc1-2,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20080132551A1,COc1ccc(N)c(-c2ncco2)c1.O=C(Cl)Oc1ccccc1>>COc1ccc(NC(=O)Oc2ccccc2)c(-c2ncco2)c1,,ClCCl,,c1ccncc1,,val
US20070232649A1,COc1cc(O)c(C=O)c(OC)c1.COc1ccc(CS(=O)(=O)CC(=O)O)cc1[N+](=O)[O-]>>COc1cc(OC)c2cc(S(=O)(=O)Cc3ccc(OC)c([N+](=O)[O-])c3)c(=O)oc2c1,,CC(=O)O,,,,val
US20070244125A1,CC(C)Br.O=C(c1ccc2[nH]c(C(=O)N3CCS(=O)(=O)CC3)cc2c1)N1CCN(C2CCC2)CC1>>CC(C)n1c(C(=O)N2CCS(=O)(=O)CC2)cc2cc(C(=O)N3CCN(C4CCC4)CC3)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20160145212A1,COc1cccc2c(-c3ccccc3)cc(-c3ccc(O)cc3)nc12.NC(=O)CCl>>COc1cccc2c(-c3ccccc3)cc(-c3ccc(OCC(N)=O)cc3)nc12,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110257151A1,CC1(C)Cc2cc(C(=O)O)ccc2NC1c1cccc(C(=O)Nc2ccccc2)c1.CS(N)(=O)=O>>CC1(C)Cc2cc(C(=O)NS(C)(=O)=O)ccc2NC1c1cccc(C(=O)Nc2ccccc2)c1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20120232051A1,CNc1cnccc1-c1ccccc1C.O=C(Cl)c1cccc(Cl)c1>>Cc1ccccc1-c1ccncc1N(C)C(=O)c1cccc(Cl)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100272680A1,CCOC(OCC)OCC.COC(=O)NN>>CCO/C=N/NC(=O)OC,,CCOC(C)=O,,,,val
US20090214444A1,CC(C)(C)OC(=O)NCCCOc1ccc2cc(CCCCN)ccc2c1.CSC(=N)NC(=O)c1nc(Cl)c(N)nc1N>>CC(C)(C)OC(=O)NCCCOc1ccc2cc(CCCCNC(=N)NC(=O)c3nc(Cl)c(N)nc3N)ccc2c1,,CCO,,CCN(C(C)C)C(C)C,,val
US20030229066A1,NCCCn1ccnc1.NC[C@@H]1C[C@H]1CN1CCN(c2csc3cc(C(F)(F)F)ccc23)CC1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>O=C(NCCCn1ccnc1)NC[C@@H]1C[C@H]1CN1CCN(c2csc3cc(C(F)(F)F)ccc23)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20070208054A1,C[C@H](NC(=O)OCc1ccccc1)c1cccc([N+](=O)[O-])c1>>C[C@H](NC(=O)OCc1ccccc1)c1cccc(N)c1,[Fe],CC(=O)O,,CCO,O,val
US20040009983A1,CC(=O)Cl.NCCCn1cc(-c2cc3nccnc3[nH]2)c2ccccc21>>CC(=O)NCCCn1cc(-c2cc3nccnc3[nH]2)c2ccccc21,,ClCCl,,CCN(CC)CC,,val
US05344843,BrCCCOc1ccccc1.COC(=O)C(=O)c1ccc(O)cc1>>COC(=O)C(=O)c1ccc(OCCCOc2ccccc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05719152,CCOC(=O)C(CCc1cc(CNC(=O)OC(C)(C)C)ccc1[N+](=O)[O-])C(=O)OCC>>CCOC(=O)C(CCc1cc(CNC(=O)OC(C)(C)C)ccc1N)C(=O)OCC,[Pd],CCOC(C)=O,,[H][H],,val
US20100331326A1,CC(C)(CCl)N=C=O.Cc1ccncc1N>>Cc1ccncc1NC(=O)NC(C)(C)CCl,,Cc1ccccc1,ClC(Cl)Cl,CO,,val
US20160185778A1,CI.COC(=O)C1CCCC1>>COC(=O)C1(C)CCCC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20140045817A1,CC(C)(C)OC(=O)N1CCC2(CC1)CO2.Cc1ccn2c(-c3ccc4cccc(O)c4n3)nnc2c1>>Cc1ccn2c(-c3ccc4cccc(OCC5(O)CCN(C(=O)OC(C)(C)C)CC5)c4n3)nnc2c1,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140213586A1,CCS(=O)(=O)Cl.O=C(c1c[nH]c2ccccc12)C(Cl)c1ccccc1>>CCS(=O)(=O)n1cc(C(=O)C(Cl)c2ccccc2)c2ccccc21,CN(C)c1ccncc1,CN(C)C=O,,O,[H-].[Na+],val
US20100278833A1,COC(=O)c1sc(-n2cnc3cnc(CO[Si](C)(C)C(C)(C)C)cc32)cc1O.C[C@H](O)c1ccccc1F>>COC(=O)c1sc(-n2cnc3cnc(CO[Si](C)(C)C(C)(C)C)cc32)cc1O[C@H](C)c1ccccc1F,,ClCCl,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110009380A1,C=Cc1cccc2cc(S(=O)(=O)c3ccccc3)cnc12.COCN(Cc1ccccc1)C[Si](C)(C)C>>O=S(=O)(c1ccccc1)c1cnc2c(C3CCN(Cc4ccccc4)C3)cccc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110218177A1,BrCCCOC1CCCCO1.[O-]P(OCc1ccccc1)OCc1ccccc1>>O=P(CCCOC1CCCCO1)(OCc1ccccc1)OCc1ccccc1,,CN(C)C=O,O,[H-].[Na+],,val
US20140243283A1,CC(=O)OC[C@H]1O[C@H](C#Cc2ccc3c(c2)C(C)(C)c2cc(C#C[C@H]4O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]4OC(C)=O)ccc2-3)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CC1(C)c2cc(C#C[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)ccc2-c2ccc(C#C[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)cc21,,CO,,CO[Na],,val
US20110112122A1,Cn1c2c(c3c(C(=O)OC(C)(C)C)c(S(=O)(=O)c4ccc([N+](=O)[O-])cc4)ccc31)C1CCC(C2)N1>>Cn1c2c(c3c(C(=O)OC(C)(C)C)c(S(=O)(=O)c4ccc(N)cc4)ccc31)C1CCC(C2)N1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20160083368A1,C#CC(C)(C)OC(C)=O.Cc1ncc[nH]1>>C#CC(C)(C)n1ccnc1C,Cl[Cu],CN(C)C=O,,CCN(CC)CC,,val
US04299821,CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O.Cl>>CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(N)=O.Cl,[Pd],CO,,,,val
US20070078164A1,CCOC(=O)N1CC[C@](O)(c2cccc(-c3ccccc3)c2)[C@@H](O)C1>>CCOC(=O)N1CC[C@H](c2cccc(-c3ccccc3)c2)[C@@H](O)C1,[Ni],CCO,,,,val
US20080194660A1,C=CCC(C)(C)CC=O>>C=CCC(C)(C)CCO,,CCO,O,[BH4-].[Na+],[Cl-].[NH4+],val
US20070135383A1,CCOC(=O)CBr.CN(C)C=O.Cc1cc2c(=O)[nH]ccc2n1Cc1ccccc1>>CCOC(=O)COc1cccc2c1cc(C)n2Cc1ccccc1,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US03967952,CCN(C=Cc1ccccc1)CC.O=C(Cl)C(=O)c1ccccc1>>CCN(C=C(C(=O)C(=O)c1ccccc1)c1ccccc1)CC,,CCOCC,,CCN(CC)CC,,val
US20150080326A1,CC(C)(C)OC(=O)Nc1ccc(C(=N)NO)cc1.O=Cc1ccc(OC(F)(F)F)cc1>>CC(C)(C)OC(=O)Nc1ccc(-c2noc(-c3ccc(OC(F)(F)F)cc3)n2)cc1,,CC(=O)O,ClC(Cl)Cl,,,val
US20120295883A1,CC(C)I.COc1nccc2c1c(-c1cc(C(=O)O)n(C(C)C)c1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1>>COc1nccc2c1c(-c1cc(C(=O)OC(C)C)n(C(C)C)c1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,O,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150299218A1,O=Cc1ccc(F)c(Cl)c1.OCCc1c[nH]c2ccccc12>>Fc1ccc(C2OCCc3c2[nH]c2ccccc32)cc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080193700A1,CCOP(OCC)OCC.Cc1nc2cc(Br)ccc2s1>>CCOP(=O)(OCC)c1ccc2sc(C)nc2c1,Cl[Pd]Cl,CN(C)C=O,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090306042A1,CC(C)(C)OC(=O)N[C@H](C#N)Cc1ccc(I)cc1.N#Cc1ccc(B(O)O)cc1F>>CC(C)(C)OC(=O)N[C@H](C#N)Cc1ccc(-c2ccc(C#N)c(F)c2)cc1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20130190249A1,N[C@@H](CCO)C(=O)O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C1N[C@H](C(=O)O)CCO1,,C1COCCO1,,[Na+].[OH-],,val
US20070287698A1,C=Cc1ccccc1Cl.O=C(Cl)Cc1ccc(Cl)cc1>>O=C1Cc2ccc(Cl)cc2C(c2ccccc2Cl)C1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04339612,CC(C)(C)C(=O)COc1ccc(Cl)cc1.O=S(=O)(Cl)Cl>>CC(C)(C)C(=O)C(Cl)Oc1ccc(Cl)cc1,,ClC(Cl)(Cl)Cl,,,,val
US04096253,CCC(=O)OC(=O)CC.COc1cc(O)c2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12>>CCC(=O)Oc1cc(OC)cc2c1[C@H]1CC[C@]3(C)C(=O)CC[C@H]3[C@@H]1CC2,,c1ccncc1,,,,val
US20080038242A1,COc1cc(C=O)ccc1-c1ccccc1>>O=Cc1ccc(-c2ccccc2)c(O)c1,,ClCCl,,BrB(Br)Br,O,val
US20100056524A1,C1COCCN1.O=[N+]([O-])c1cnc(Cl)nc1>>O=[N+]([O-])c1cnc(N2CCOCC2)nc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US04447441,N.NC(=O)CCCCn1ccc(NC(=S)NCC(F)(F)F)n1>>NC(=O)CCCCn1ccc(NC(N)=NCC(F)(F)F)n1,,CCO,,,,val
US20160168090A1,CC(C)(C)OC(=O)N1CCCC(CO)C1.O=C(NCC1CCC(F)(F)CC1)c1c[nH]c2cccc(Cl)c12>>O=C(NCC1CCC(F)(F)CC1)c1cn(CC2CCCNC2)c2cccc(Cl)c12,,Cc1ccccc1,,CCCCP(=CC#N)(CCCC)CCCC,,val
US05266568,Clc1ccc2ccc(COc3cccc(CBr)c3)nc2c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Clc1ccc2ccc(COc3cccc(C[P+](c4ccccc4)(c4ccccc4)c4ccccc4)c3)nc2c1.[Br-],,CC#N,,CCOCC,,val
US06329381B1,N#CCCCl.Nc1nc(S)nc2c1nc(O)n2Cc1ccccc1>>N#CCCSc1nc(N)c2nc(O)n(Cc3ccccc3)c2n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070265242A1,CC(C)(C)C(=O)OCI.C[C@@H](O)[C@H]1C(=O)N2C(C(=O)[O-])=C(c3ccc4c(c3)oc(=O)n4C)C[C@H]12>>C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCOC(=O)C(C)(C)C)=C(c3ccc4c(c3)oc(=O)n4C)C[C@H]12,,CN(C)C=O,,CCOC(C)=O,,val
US08080566B1,CC(C)(C)OC(=O)N1CCCC(c2cn[nH]c2)C1.Cl>>Cl.c1n[nH]cc1C1CCCNC1,,C1COCCO1,,,,val
US20050164960A1,CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2ccc3c(N)ncnc32)[C@](C)(O)[C@@H]1O.COc1ccc(C(Cl)(c2ccccc2)c2ccccc2)cc1>>COc1ccc(N(c2ncnc3c2ccn3[C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](O)[C@@]2(C)O)C(c2ccccc2)c2ccccc2)cc1,CN(C)c1ccncc1,c1ccncc1,,CCOC(C)=O,,val
US04071625,C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@@]43CO[Si](C)(C)C)[C@@H]1CC[C@@H]2O>>C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@@]43CO[Si](C)(C)C)[C@@H]1CCC2=O,,CC(C)=O,,O=S(=O)(O)O,O=[Cr](=O)=O,val
US20080214448A1,CCOC(=O)CCCCc1cc(-c2cc(Cl)ccc2O)on1>>O=C(O)CCCCc1cc(-c2cc(Cl)ccc2O)on1,,C1COCCO1,O,Cl,[Li]O,val
US05326760,C(=NC1CCCCC1)=NC1CCCCC1.CC(C)C[C@H](N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(=O)OC(C)(C)C)C(=O)O.CN(C)C=O.Oc1cccc2[nH]nnc12>>CC(C)C[C@H](N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(=O)OC(C)(C)C)C(=O)NCc1nn[nH]n1,,O,,,,val
US06005107,CCO[PH](=O)[C@H]1CC[C@H](CBr)O1.Cc1c[nH]c(=O)[nH]c1=O>>CCn1cc(C)c(=O)[nH]c1=O,,CN(C)C=O,,[H-].[Na+],,val
US05221676,c1ccc(CN2CCC(c3ccccn3)C2)cc1>>c1ccc(C2CCNC2)nc1,[Pd],CO,O,O=C[O-].[NH4+],,val
US20070066624A1,CC(C)(C)OC(=O)N1CCC(N[C@@H](CN2C(=O)c3ccccc3C2=O)c2ccccc2)CC1>>CC(C)(C)OC(=O)N1CCC(N[C@@H](CN)c2ccccc2)CC1,,CCO,,NN,O,val
US06172234B2,COC(=O)C1CCCN1[C@@H](C)c1ccccc1.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>COC(=O)[C@@H]1CCCN1[C@@H](C)c1ccccc1.O=C(O)[C@H](O)[C@@H](O)C(=O)O,,Cc1ccccc1,,CO,,val
US20050070582A1,N.O=C(O)c1ccc(Oc2cc(Cl)cc(Cl)c2)c([N+](=O)[O-])c1>>NC(=O)c1ccc(Oc2cc(Cl)cc(Cl)c2)c([N+](=O)[O-])c1,,C1CCOC1,O,O=C(n1ccnc1)n1ccnc1,,val
US20100298336A1,Cc1cc(O)nc(S)n1.Cn1cc(Cl)c(CBr)n1>>Cc1cc(O)nc(SCc2nn(C)cc2Cl)n1,,CCO,,CCN(CC)CC,,val
US05608056,C=CCOC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1CCn1ccnc1CO[Si](C)(C)C(C)(C)C>>C=CCOC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1CCn1ccnc1CO,,CO,,Cl,,val
US06017919,CCCCCOc1c(CO)cccc1OC>>CCCCCOc1c(C=O)cccc1OC,,O,,CCN(CC)CC,CS(C)=O,val
US20150266878A1,O=C(CO)NC[C@H](Nc1cncc(-c2ccc3[nH]nc(F)c3c2)c1)c1ccccc1>>OCCNC[C@H](Nc1cncc(-c2ccc3[nH]nc(F)c3c2)c1)c1ccccc1,,C1CCOC1,,,,val
US05750764,CC(=O)OC(C)=O.CCOC(=O)C(C)(O)c1ccc2cc(OC)ccc2c1.Cc1ccccc1>>CCOC(=O)C(C)c1ccc2cc(OC)ccc2c1.COc1ccc2ccccc2c1,[Pd],Cc1ccccc1,,,,val
US20140364414A1,N#Cc1ccc(-c2cnc(N3CCOCC3)c3nc(C=O)cn23)cn1>>N#Cc1ccc(-c2cnc(N3CCOCC3)c3nc(CO)cn23)cn1,,CO,O,[BH4-].[Na+],,val
US20160046618A1,CC(C)(C)OC(=O)N(COCC[Si](C)(C)C)C1=N[C@](CF)(c2cc(Br)ccc2F)C=C(CO)S1.CC1=CC(=O)OC(C)(C)O1>>CC(=O)CC(=O)OCC1=C[C@@](CF)(c2cc(Br)ccc2F)N=C(N(COCC[Si](C)(C)C)C(=O)OC(C)(C)C)S1,,Cc1ccccc1C,,,,val
US03954753,Br[Mg]c1ccccc1.Nc1ncc(Cl)nc1C(=O)N1CCCC1>>Nc1ncc(Cl)nc1C(=O)c1ccccc1,,O,,C1CCOC1,,val
US05296484,CC(O)c1ccc(C(C)(C)C)cc1.Clc1ncnc2ccccc12>>CC(Oc1ncnc2ccccc12)c1ccc(C(C)(C)C)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20040048858A1,COc1ccc(C(=O)NNC(=S)NCC(C)C)c(OC)c1>>COc1ccc(-c2nnc(S)n2CC(C)C)c(OC)c1,,CCO,,[Na+].[OH-],,val
US06410566B1,O=C(CNC(=O)OCC1c2ccccc2-c2ccccc21)NCC1CCNCC1.O=C(Nc1ccccc1)c1ccc(CCl)cc1>>NCC(=O)NCC1CCN(Cc2ccc(C(=O)Nc3ccccc3)cc2)CC1,,CC#N,,CCN(CC)CC,,val
US20150291563A1,CS(=O)(=O)Cl.FC(F)(F)C(F)(F)C1=NN(c2ccccc2Cl)C(c2cccc(C3=CCNCC3)c2)C1>>CS(=O)(=O)N1CC=C(c2cccc(C3CC(C(F)(F)C(F)(F)F)=NN3c3ccccc3Cl)c2)CC1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US05591884,CCOC(=O)CBr.COc1ccc2c(c1OC)CC(c1ccccc1)CC2=O>>CCOC(=O)CC1C(=O)c2ccc(OC)c(OC)c2CC1c1ccccc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20110172245A1,CC(=O)Cl.N#CC1(c2cccc(C(=O)Nc3cccc(Oc4ccc5nc(N)sc5c4)c3)c2)CC1>>CC(=O)Nc1nc2ccc(Oc3cccc(NC(=O)c4cccc(C5(C#N)CC5)c4)c3)cc2s1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,O,val
US04198532,C#CC(=C)C.CC(=O)CC(C)C>>C=C(C)C#CC(C)(O)CC(C)C,,Cc1ccccc1,,[K+].[OH-],,val
US20020143034A1,OC[C@H](Cc1ccc(O)cc1)NCc1ccccc1.c1ccc(OC[C@@H]2CO2)cc1>>OC[C@H](Cc1ccc(O)cc1)N(Cc1ccccc1)C[C@H](O)COc1ccccc1,,CCO,,,,val
US20100105655A1,COc1cc(N2CCNCC2)ccc1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1.O=C(O)CO>>COc1cc(N2CCN(C(=O)CO)CC2)ccc1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1,,CC(=O)N(C)C,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080004323A1,C#CC(=Nc1ccccc1)N(C)c1ccccc1.Sc1ccc(Cl)cc1>>CN(C(C=CSc1ccc(Cl)cc1)=Nc1ccccc1)c1ccccc1,,ClC(Cl)Cl,,,,val
US20140038926A1,Cn1ccnc1Br.O=C[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(C(F)(F)F)cc1)C2>>Cn1ccnc1C(O)[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(C(F)(F)F)cc1)C2,,CCOCC,,O,[Li]CCCC,val
US20050043379A1,C[Si](C)(C)N=[N+]=[N-].N#CCCNC(=O)C1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1>>N#CCCn1nnnc1C1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1,,CC#N,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150344425A1,CC(=O)c1cc(C(=O)NCC2(O)CCC(F)(F)CC2)c(Cl)c2cc[nH]c12.C[Mg]Br>>CC(C)(O)c1cc(C(=O)NCC2(O)CCC(F)(F)CC2)c(Cl)c2cc[nH]c12,,C1CCOC1,,CCOCC,,val
US20120129811A1,CC(C)Oc1ccc(S(N)(=O)=O)cc1N.S=C(Cl)Cl>>CC(C)Oc1ccc(S(N)(=O)=O)cc1N=C=S,,ClC(Cl)Cl,O,O=C([O-])O.[Na+],,val
US20080287475A1,CSC(=CC#N)N(C)C.NN>>CN(C)c1cc(N)n[nH]1,,CCO,,O,,val
US03958974,Nc1ccc(C(F)(F)F)cc1.O=C(Cl)CCCl>>O=C(CCCl)Nc1ccc(C(F)(F)F)cc1,,c1ccccc1,,,,val
US20050026964A1,Cn1cc(C(=O)O)c(Nc2ccc(F)cc2F)cc1=O.NCCCO>>Cn1cc(C(=O)NCCCO)c(Nc2ccc(F)cc2F)cc1=O,,C1CCOC1,CN(C)C=O,O=C(n1ccnc1)n1ccnc1,,val
US20090149463A1,Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(O)cc1.O=S(=O)(Cl)c1ccc(Cl)s1>>Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(OS(=O)(=O)c2ccc(Cl)s2)cc1,,ClCCl,,CCN(CC)CC,,val
US20070149570A1,COc1ccc(-c2ccc(C#N)cc2)cc1C=O.C[Mg]Br>>COc1ccc(-c2ccc(C#N)cc2)cc1C(C)O,,C1CCOC1,,CCOCC,O,val
US04483861,CC(=O)Oc1ccccc1C1N[C@H](C(=O)O)CS1.Cc1ccc(C(=O)SCCC(=O)Cl)cc1>>CC(=O)Oc1ccccc1C1SC[C@@H](C(=O)O)N1C(=O)CCSC(=O)c1ccc(C)cc1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20090264437A1,CC(C)(C)c1nc(C2CCC2)cc(N2CCN(CCCCN)CC2)n1.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>CC(C)(C)c1nc(C2CCC2)cc(N2CCN(CCCCNC(=O)c3ccc([N+](=O)[O-])cc3)CC2)n1,,C1CCOC1,,CCN(CC)CC,,val
US20040138277A1,CCOC(=O)C(C)(Cc1ccc(OCCc2nc(-c3cccc(-c4ccc(F)cc4)c3)oc2C)cc1)Oc1ccccc1>>Cc1oc(-c2cccc(-c3ccc(F)cc3)c2)nc1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1,,CO,,[Na+].[OH-],,val
US20140057916A1,CCc1ccc(C#N)cn1.O=C1CCC(=O)N1Br>>CC(Br)c1ccc(C#N)cn1,,ClC(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20150119373A1,C=C(C)[C@@H]1CC[C@]2(C(=O)N3CCN(CC)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(=O)[C@H]6[C@@H](CC(=O)OC)C6(C)C)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(C(=O)N3CCN(CC)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(=O)[C@H]6[C@@H](CC(=O)O)C6(C)C)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1COCCO1,ClCCl,[Na+].[OH-],,val
US20130178460A1,Cn1ccc(NC(=O)c2csc3cnc(N[C@@H]4CCOC[C@@H]4NC(=O)OC(C)(C)C)nc23)n1>>Cn1ccc(NC(=O)c2csc3cncnc23)n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20070208054A1,C[C@@H](C(=O)O)c1ccc(Br)cc1>>C[C@@H](CO)c1ccc(Br)cc1,,C1CCOC1,,CCOC(C)=O,,val
US20040082570A1,C=CCn1c(Cl)nc2c1c(=O)n(C)c(=O)n2C.CC(C)(C)OC(=O)N1CCNCC1>>C=CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2c1c(=O)n(C)c(=O)n2C,,CN1CCCC1=O,,C1CCC2=NCCCN2CC1,,val
US06479512B1,CCOC(=O)c1cc2ccc(Cl)cc2[nH]c1=O.Nc1ccccc1N>>O=c1[nH]c2cc(Cl)ccc2cc1-c1nc2ccccc2[nH]1,,,,O=C([O-])O.[Na+],,val
US03933830,COc1ncccc1CCl.NCCc1ccncc1.O>>COc1ncccc1C(=O)NCCc1ccncc1,,ClCCl,O,O=C([O-])[O-].[Na+].[Na+],,val
US20150094281A1,C=C[C@H](CCC(C)C)[C@@H](O)[C@H](C)OCc1ccc(OC)cc1.Cc1ccc(S(=O)(=O)OCC(C)C)cc1>>C=C[C@H](CCC(C)C)[C@@H](OCC(C)C)[C@H](C)OCc1ccc(OC)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05990261,O=[N+]([O-])c1cc(Oc2cccc(Oc3cc([N+](=O)[O-])cc(C(F)(F)F)c3)c2)cc(C(F)(F)F)c1>>Nc1cc(Oc2cccc(Oc3cc(N)cc(C(F)(F)F)c3)c2)cc(C(F)(F)F)c1,[Pd],CC(C)O,,Cl,[H][H],val
US07199105B2,C1CO1.CCCCCC1CNC(C(=O)NC(C(C)C)C2OC(SC)C(O)C(O)C2O)C1>>CCCCCC1CC(C(=O)NC(C(C)C)C2OC(SC)C(O)C(O)C2O)N(CCO)C1,,CO,,CCN(C(C)C)C(C)C,,val
US20100249229A1,CCC1=C[C@H]2[C@@H](C1)C[C@]2(CC(=O)OC(C)(C)C)C[N+](=O)[O-]>>CCC1=C[C@H]2[C@@H](C1)C[C@@]2(CN)CC(=O)O,[Fe],CCO,O,[Cl-].[NH4+],,val
US20060160802A1,COC(=O)C1(C=O)CCCCCC1.NOCc1ccccc1>>COC(=O)C1(C=NOCc2ccccc2)CCCCCC1,,CO,,Cl,CC(=O)[O-].[Na+],val
US20080085887A1,COc1nccc2nc(-c3ccccc3OCc3ccccc3)n(CCc3ccccc3)c(=O)c12>>COc1nccc2nc(-c3ccccc3O)n(CCc3ccccc3)c(=O)c12,[Pd],CO,,,,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)n3nc4cc(Br)ccc4c3[nH]2)CC1.Cl>>Cl.O=c1cc(C2CCNCC2)n2nc3cc(Br)ccc3c2[nH]1,,C1COCCO1,CO,,,val
US05286734,Cl.FC(F)(F)c1cccc(C2=CCN(CCc3ccc4ccccc4c3)CC2)c1>>Cl.FC(F)(F)c1cccc(C2CCN(CCc3ccc4ccccc4c3)CC2)c1,[Pd],CCO,,,,val
US20040006141A1,CCCCC(Cc1ccc(OCc2ccccc2)cc1)C(=O)OCC>>CCCCC(Cc1ccc(O)cc1)C(=O)OCC,[Pd],,,,,val
US20120004218A1,CC(C)CCI.CCC1(C)CC(c2ccc(F)c(Cl)c2)Nc2ccc(C(=O)OC)nc21>>CCC1(C)CC(c2ccc(F)c(Cl)c2)N(CCC(C)C)c2ccc(C(=O)OC)nc21,,CN(C)C=O,,[H-].[Na+],,val
US20020103186A1,C1CNCCNC1.O=[N+]([O-])c1ccc(F)c(F)c1>>O=[N+]([O-])c1ccc(N2CCCNCC2)c(F)c1,,CC#N,,,,val
US20100286148A1,N#Cc1ncc(Cl)c(Cl)c1Cl.OCC(F)(F)F>>N#Cc1ncc(Cl)c(OCC(F)(F)F)c1Cl,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20120053052A1,CC(=O)Nc1cc(S)c(C)cc1F>>Cc1cc(F)c(N)cc1S,,O,,Cl,[K+].[OH-],val
US20100075973A1,CC(C)(C)OC(=O)NC1CCN(C2CCN(CC3CC3)CC2)CC1.Cl>>Cl.NC1CCN(C2CCN(CC3CC3)CC2)CC1,,CO,,,,val
US20070179165A1,CC(C)(C)C(=O)Cl.Cn1ccc2c(=O)[nH]c(N)nc21>>Cn1ccc2c(=O)[nH]c(NC(=O)C(C)(C)C)nc21,,O,c1ccncc1,,,val
US04814332,COc1ccc(-c2nccn2N=Cc2ccc(N(C)C)cc2)cc1.O=C(CBr)c1ccc(Cl)cc1>>COc1ccc(-c2n(N=Cc3ccc(N(C)C)cc3)cc[n+]2CC(=O)c2ccc(Cl)cc2)cc1.[Br-],,CC#N,,,,val
US20050282891A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1)C(=O)O.O=C(NCCO)c1ccccc1OCc1ccccc1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1)C(=O)OCCNC(=O)c1ccccc1OCc1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20090048258A1,CCOC(=O)c1cc(-c2ccccc2)n(-c2ccc(OC(F)(F)F)cc2)c1C>>Cc1c(C(=O)O)cc(-c2ccccc2)n1-c1ccc(OC(F)(F)F)cc1,,CCO,,Cl,[Na+].[OH-],val
US20120035143A1,C#CCC.Nc1ccc(F)cc1I>>CCC#Cc1cc(F)ccc1N,I[Cu]I,CCN(CC)CC,,C1CCOC1,,val
US20110003867A1,CCc1nc(NCc2ccc(F)cc2)cc(NC)c1[N+](=O)[O-]>>CCc1nc(NCc2ccc(F)cc2)cc(NC)c1N,[Ni],CCO,O,,,val
US20080108659A1,CC(C)(C)OC(=O)N1CCC(N)CC1.COC(=O)c1c(C#N)cccc1CBr>>CC(C)(C)OC(=O)N1CCC(N2Cc3cccc(C#N)c3C2=O)CC1,,C1CCOC1,CN(C)C=O,,,val
US20110118246A1,C=C(C)B(O)O.O=C(Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12)c1ncccc1Br>>C=C(C)c1cccnc1C(=O)Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20110207754A1,C=C1CC(C=O)C1.CCOP(=O)(CC#N)OCC>>C=C1CC(C=CC#N)C1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US04409229,CN1CCC2(CC1)SC(c1ccccc1Cl)c1ccccc12.O=C(Cl)Oc1ccccc1>>O=C(Oc1ccccc1)N1CCC2(CC1)SC(c1ccccc1Cl)c1ccccc12,,ClCCl,,,,val
US20110281854A1,C[C@@H]1CN[C@H](c2ccc(F)cc2F)CO1.O=C1COc2ccc(Br)nc2N1>>C[C@@H]1CN(c2ccc3c(n2)NC(=O)CO3)[C@H](c2ccc(F)cc2F)CO1,,CS(C)=O,,,,val
US20160222005A1,CCS(=O)(=O)Cl.c1ccc(COc2ccc(-c3nc4ccc(C5CCNCC5)nc4[nH]3)cc2)cc1>>CCS(=O)(=O)N1CCC(c2ccc3nc(-c4ccc(OCc5ccccc5)cc4)[nH]c3n2)CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,O,val
US04048317,CC(C)N[C@@H]1c2cc([N+](=O)[O-])ccc2OC(C)(C)[C@H]1O.O=S(=O)(O)O>>CC(C)N[C@@H]1c2cc(N)ccc2OC(C)(C)[C@H]1OS(=O)(=O)O,,CCO,Cl,CCOCC,,val
US20020049220A1,C[C@H](Nc1nccc(-n2cc(Br)nc2-c2ccc(F)cc2)n1)c1ccccc1.OB(O)c1ccsc1>>C[C@H](Nc1nccc(-n2cc(-c3ccsc3)nc2-c2ccc(F)cc2)n1)c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US04971967,CN.Fc1ccc(-n2c(CCl)csc2=S)c(F)c1F>>CN1Cc2csc(=S)n2-c2ccc(F)c(F)c21,,CC#N,CO,,,val
US20150197493A1,O=C(Nc1ccc(F)c(Cl)c1)c1ccc(CCF)c(S(=O)(=O)N2CCCC(OCc3ccccc3)CC2)c1>>O=C(Nc1ccc(F)c(Cl)c1)c1ccc(CCF)c(S(=O)(=O)N2CCCC(O)CC2)c1,[Pd],CO,,,,val
US04680287,CCCCCCCCCCCCCCCCCCN.C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C=O>>CCCCCCCCCCCCCCCCCCNC1O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]1O,,CCO,,,,val
US20110021771A1,CCOC(=O)CC(=O)c1ccccc1.O=C(CBr)c1ccccc1>>CCOC(=O)C(CC(=O)c1ccccc1)C(=O)c1ccccc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US04876249,CCCCCCCCCC(=O)NC(C)(C#N)C(C)(C)C.CCO>>CCCCCCCCCCCC1=NC(C)(C(C)(C)C)CN1,[Ni],[NH4+],[OH-],,,val
US20060173018A1,Cc1ccc2c(N3CCC[C@H](CNC(=O)OCc4ccccc4)C3)nc(-c3ccccc3O)nc2c1>>Cc1ccc2c(N3CCC[C@H](CN)C3)nc(-c3ccccc3O)nc2c1,[Pd],CCO,,,,val
US20080167377A1,Cc1ccc(OCc2cccc(Cl)c2)cc1C(=O)O.O=C(Cl)C(=O)Cl>>Cc1ccc(OCc2cccc(Cl)c2)cc1C(=O)Cl,CN(C)C=O,ClCCl,,,,val
US20100152450A1,CC(C)(C)OC(=O)N1CCC[C@H]1COc1cncc(N2CC[C@@H](COCCCc3ccccc3)C2)c1>>c1ccc(CCCOC[C@@H]2CCN(c3cncc(OC[C@@H]4CCCN4)c3)C2)cc1,,ClCCl,,O,O=C(O)C(F)(F)F,val
US20160168139A1,CI.COC(=O)c1ccnc(CO)c1>>COCc1cc(C(=O)OC)ccn1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20110263559A1,CCc1nn(-c2ccccc2)c(N)c1C(N)=O.NC(N)=O>>CCc1nn(-c2ccccc2)c2[nH]c(=O)[nH]c(=O)c12,,[Na+],[OH-],CC(=O)O,,val
US20140066457A1,CC[Si](CC)(CC)c1[nH]c2ncc(Cl)cc2c1CCN.O=C(O)c1cc(Cc2cc(F)ccc2F)on1>>NC(=O)c1cc(Cc2cc(F)ccc2F)on1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120101064A1,CN(C)C1CCN(c2ccc([N+](=O)[O-])c(N)c2)CC1>>CN(C)C1CCN(c2ccc(N)c(N)c2)CC1,[Pd],CCO,,,,val
US20150148340A1,NC(N)=O.NC1CCc2c1cccc2C(F)(F)F>>NC(=O)NC1CCc2c1cccc2C(F)(F)F,,O,,Cl,,val
US20080176830A1,NCc1ccccc1.O=c1cc(O)c2cc(Br)ccc2[nH]1>>O=c1cc(NCc2ccccc2)c2cc(Br)ccc2[nH]1,,Cl,,,,val
US20140371283A1,Cc1cc(C=O)ccc1OC(F)F.Fc1cccc(C2SCCCS2)c1>>Cc1cc(C(O)C2(c3cccc(F)c3)SCCCS2)ccc1OC(F)F,,C1CCOC1,,[Li]CCCC,,val
US20100298324A1,COC(=O)c1ccc2c(=O)n(-c3ncc(OC)cc3OC)c(=S)[nH]c2c1>>COc1cnc(-n2c(=S)[nH]c3cc(C(=O)O)ccc3c2=O)c(OC)c1,,CO,,[Na+].[OH-],,val
US20100120739A1,COC(=O)Cc1cc2cc(Br)cnc2cc1F>>O=C(O)Cc1cc2cc(Br)cnc2cc1F,,[Na+],[OH-],,,val
US20010051651A1,CCOC(=O)Cc1cccn1C.N#Cc1ccc(C(=O)Cl)cc1>>CCOC(=O)Cc1ccc(C(=O)c2ccc(C#N)cc2)n1C,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20130082209A1,CC(C)(C)c1cc(N)c(Br)cn1.Cl.Cl.Nc1c(F)c(N)c(F)c(F)c1F>>CC(C)(C)c1cc(N)c(N)cn1.Cl.Cl,,CCO,,Cl,,val
US20090306123A1,CC(C(=O)NO)C(=O)C(F)(F)F>>Cc1c(O)noc1C(F)(F)F,,O=S(=O)(O)O,,O,,val
US20140080808A1,Cn1cc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO[Si](C)(C)C(C)(C)C)C5)CC3)cc2F)cn1>>Cn1cc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO)C5)CC3)cc2F)cn1,,CO,,Cl,,val
US05849757,CCOC(=O)C1(C2CN(C(=O)OCc3ccccc3)C2)CC1>>O=C(OCc1ccccc1)N1CC(C2(C(=O)O)CC2)C1,,CCO,,[Na+].[OH-],,val
US20120035206A1,O=C(Cl)CCl.O=C1C(=CO)CSc2ccc(F)cc21>>O=C1/C(=C/Cl)CSc2ccc(F)cc21,,ClCCl,,,,val
US04382929,COC(=O)c1csc(CN(C)C)c1>>CN(C)Cc1cc(CO)cs1,,CCOCC,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20070249670A1,Cc1cc(C)c(NC(=O)Nc2cc3ccccc3cc2C(=O)O)c(C)c1.NCC1CCCCC1>>Cc1cc(C)c(NC(=O)Nc2cc3ccccc3cc2C(=O)NCC2CCCCC2)c(C)c1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04978386,N#CCC(C(=O)Cc1cccc(C(F)(F)F)c1)c1ccccc1>>NC1=C(c2cccc(C(F)(F)F)c2)C(=O)C(c2ccccc2)C1,,CO,,[Na],,val
US20120208798A1,CC(=O)N1c2ccc(Br)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.CCCC[Sn](CCCC)(CCCC)c1cncn1C>>CC(=O)N1c2ccc(-c3cncn3C)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCCCCC,CCOC(C)=O,,,val
US20050288346A1,Cc1c(O)ccc(C(=O)CC2CCCC2)c1O.N#Cc1ccc(OCCCCBr)cc1>>Cc1c(OCCCCOc2ccc(C#N)cc2)ccc(C(=O)CC2CCCC2)c1O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04217453,ClP(Cl)Cl.[N-]=[N+]=NC1C(=O)N2C(C(=O)OCc3ccccc3)C(=O)CC12>>[N-]=[N+]=NC1C(=O)N2C(C(=O)OCc3ccccc3)=C(Cl)CC12,,CN(C)C=O,Cc1ccccc1,,,val
US20100298324A1,COc1ncnc(OC)c1-n1c(=S)[nH]c2cc(C(=O)O)ccc2c1=O.NCc1ccc(Cl)cc1>>COc1ncnc(OC)c1-n1c(=O)c2ccc(C(N)=O)cc2n(Cc2ccc(Cl)cc2)c1=S,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120039849A1,COc1cncc(Br)c1.ClCCl>>CCOc1cncc(Br)c1,,ClCCl,,O=C(OO)c1cccc(Cl)c1,,val
US20040132727A1,COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.NC1CCN(Cc2ccccc2Cl)C1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)NC4CCN(Cc5ccccc5Cl)C4)cc3)c2cc1OC,,CCN(CC)CC,ClC(Cl)Cl,O=C([O-])O.[Na+],,val
US20080004271A1,CCOC(=O)c1sc2nc(SC)nc(-c3ccc(F)c(C)c3)c2c1N>>CSc1nc(-c2ccc(F)c(C)c2)c2c(N)c(C(=O)O)sc2n1,,C1CCOC1,O,[Li+].[OH-],,val
US20120035163A1,COCc1ccc(Oc2cc(OC3CCOCC3)c3[nH]c(C(N)=O)cc3c2)cn1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COCc1ccc(Oc2cc(OC3CCOCC3)c3[nH]c(C(N)=S)cc3c2)cn1,,C1CCOC1,,CCCCCC,CCOC(C)=O,val
US04952690,C=C(C)C(C(=O)OC)N1C(=O)[C@H](OC)[C@H]1SSc1nc2ccccc2s1>>COC(=O)C(=C(C)C)N1C(=O)[C@H](OC)[C@H]1SSc1nc2ccccc2s1,,ClCCl,,CCN(CC)CC,,val
US20060173018A1,Cc1ccc2c(N3CCCC(CNC(=O)OCc4ccccc4)C3)nc(-c3ccccc3O)nc2c1>>Cc1ccc2c(N3CCCC(CN)C3)nc(-c3ccccc3O)nc2c1,[Pd],CCO,CCOC(C)=O,N#N,,val
US20120202775A1,O=[N+]([O-])c1cc2ccccc2[nH]1.[NH-]C(=O)C=O>>Nc1cc2ccccc2[nH]1.[NH-]C(=O)C=O,[Pd],CCO,,,,val
US20130274241A1,CC(=O)Cl.NCc1ccc(-n2cc(-c3n[nH]c4ccccc34)nn2)cc1>>CC(=O)NCc1ccc(-n2cc(-c3n[nH]c4ccccc34)nn2)cc1,,CN(C)C=O,ClCCl,,,val
US20070032485A1,CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(C(=O)NC(CO)C(=O)OC)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC>>CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(C(=O)NC(CO)C(=O)O)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC,,CO,,[Na+].[OH-],,val
US20070179138A1,C1COCCN1.CCOc1ccc(-c2cc3c(ncn3CCBr)c(C#N)n2)cc1C(F)(F)F>>CCOc1ccc(-c2cc3c(ncn3CCN3CCOCC3)c(C#N)n2)cc1C(F)(F)F,,CN(C)C=O,CO,,,val
US20160072082A1,Cc1cccc2c1c1ccccc1c1nccn21.O=C1CCC(=O)N1Br>>Cc1cccc2c1c1ccccc1c1ncc(Br)n21,,ClCCl,,O,,val
US04402970,Cc1c(C(=O)c2ccccc2)c(NC(=O)CI)cn1C.NO>>Cc1c(C(=O)c2ccccc2)c(NC(=O)CNO)cn1C,,CCO,O,Cl,[Na+].[OH-],val
US20090247474A1,Br[Mg]c1ccccc1.CC(C)(C)OC(=O)N[C@@H]1CCN(C2CC3CCC(C2)C3=O)C1>>CC(C)(C)OC(=O)N[C@@H]1CCN(C2CC3CCC(C2)C3(O)c2ccccc2)C1,,C1CCOC1,,,,val
US20110015157A1,C[C@@H](c1ccc(OC(F)F)cc1)N1CC[C@](CCC(=O)O)(c2ccc(F)cc2)OC1=O.N>>C[C@@H](c1ccc(OC(F)F)cc1)N1CC[C@](CCC(N)=O)(c2ccc(F)cc2)OC1=O,,C1CCOC1,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04159984,COC(=O)C(=C(C)C)N1C(=O)C2NC(C(=O)OCc3ccccc3)OC21.O=C(Cl)Cc1ccccc1>>COC(=O)C(=C(C)C)N1C(=O)C2(C(=O)Cc3ccccc3)NC(C(=O)OCc3ccccc3)OC12,,C1CCOC1,,CCN(CC)CC,O,val
US20150315198A1,[N-]=[N+]=NCc1cc(-c2ccc(Cl)s2)on1>>NCc1cc(-c2ccc(Cl)s2)on1,,O,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090131470A1,Cc1cc2nc(-c3n[nH]c(C)c3C(=O)O)[nH]c2cc1C.NC1CCCN(C(=O)OCc2ccccc2)C1>>Cc1cc2nc(-c3n[nH]c(C)c3C(=O)NC3CCCNC3)[nH]c2cc1C,,CCOC(C)=O,CN(C)C=O,ClCCCl,On1nnc2ccccc21,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC(=O)CC2)c2nc(C)nn12>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC(O)CC2)c2nc(C)nn12,,C1CCOC1,,CO,[BH4-].[Na+],val
US06281357B1,CNS(=O)(=O)CC#N.ClCOCc1ccccc1>>CN(COCc1ccccc1)S(=O)(=O)CC#N,,C1CCOC1,,[H-].[Na+],,val
US20030149250A1,BrCc1ccc(I)cc1.CCOP(OCC)OCC>>CCOP(=O)(Cc1ccc(I)cc1)OCC,,CCOC(C)=O,,,,val
US20100093668A1,CCOP(=O)(CCBr)OCC.NC1CCN(Cc2ccccc2)CC1>>CCOP(=O)(CCNC1CCN(Cc2ccccc2)CC1)OCC,,CCO,,,,val
US20120295875A1,CCC(=O)C(C)Br.OB1OCc2ccc(O)cc21>>CCC(=O)C(C)Oc1ccc2c(c1)B(O)OC2,,CN(C)C=O,,Cl,[H-].[Na+],val
US20050245593A1,CCOC(=O)Cc1c(C)[nH]c2ccc(F)cc12>>Cc1[nH]c2ccc(F)cc2c1CC(=O)O,,CO,O,[K+].[OH-],,val
US20140148451A1,CS(=O)(=O)Cl.O=C(NCCCCO)OCc1ccccc1>>CS(=O)(=O)OCCCCNC(=O)OCc1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US04816464,C1CC2(CCN1)OCCO2.CCCCCCCCI>>CCCCCCCCN1CCC2(CC1)OCCO2,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20100298342A1,CC1CC(=O)CCN1Cc1ccccc1.C[Si](C)(C)C#N.Nc1cccc(F)c1>>CC1CC(C#N)(Nc2cccc(F)c2)CCN1Cc1ccccc1,,CC(=O)O,,[NH4+].[OH-],,val
US20130184253A1,CC(=O)OC(C)=O.C[C@@H]1CNCCN1C(=O)OC(C)(C)C>>CC(=O)N1CCN(C(=O)OC(C)(C)C)[C@H](C)C1,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US20090306066A1,CC[C@@H]1CN(Cc2ccccc2)[C@H](C)CN1C>>CC[C@@H]1CN[C@H](C)CN1C,,CO,,,,val
US20020086858A1,Cc1cc(N2CCCC2)nc(/C=C/c2cccc([N+](=O)[O-])c2)n1>>Cc1cc(N2CCCC2)nc(/C=C/c2cccc(N)c2)n1,,CCO,,Cl,[Na+].[OH-],val
US04892875,CC(=O)CC(=O)OCCN1CCN(c2cccc(C(F)(F)F)c2)CC1.COC(=O)/C=C(/C)N.O=Cc1cccc([N+](=O)[O-])c1>>COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C1c1cccc([N+](=O)[O-])c1,,CC(C)O,,,,val
US03960892,O=C(O)CC(=O)c1ccccc1.O=C1CSC(=S)N1>>CC(=C1SC(=S)NC1=O)c1ccccc1C(=O)O,,O,,CC(=O)O,CC(=O)[O-].[Na+],val
US20150232463A1,Cc1nc(C)c([C@H](OC(C)(C)C)C(=O)OC(C)C)c(N2CCC(c3nc(C(C)C)no3)CC2)c1-c1ccc(OCCc2ccc(F)cc2)cc1>>Cc1nc(C)c([C@H](OC(C)(C)C)C(=O)O)c(N2CCC(c3nc(C(C)C)no3)CC2)c1-c1ccc(OCCc2ccc(F)cc2)cc1,,CCO,,Cl,[K+].[OH-],val
US04572805,C=CC(=O)Cl.N#Cc1c(F)c(F)c(O)c(F)c1F>>C=CC(=O)Oc1c(F)c(F)c(C#N)c(F)c1F,,ClC(Cl)(Cl)Cl,,,,val
US20050261291A1,Cc1ccc(C2=CCN(C(=O)OC(C)(C)C)CC2)c(C2CC(C)(C)CC(C)(C)C2)c1>>Cc1ccc(C2=CCNCC2)c(C2CC(C)(C)CC(C)(C)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130281505A1,CON.O=C1CCCCc2ccc(I)cc21>>CON=C1CCCCc2ccc(I)cc21,,CO,,Cl,c1ccncc1,val
US20130116234A1,CCOC(=O)CC(=O)Nc1ccc(Cl)cc1C#Cc1ccccc1Cl>>CCOC(=O)c1c(O)nc2ccc(Cl)cc2c1Cc1ccccc1Cl,,CCOC(C)=O,CS(C)=O,[H-].[Na+],,val
US20090099213A1,CCOC(Cc1c(N)nc(S)nc1O)OCC>>CCOC(Cc1c(N)ncnc1O)OCC,[Ni],O,,,,val
US05455351,CC(C)C(N)=S.O=C(CCl)CCl>>CC(C)c1nc(CCl)cs1.Cl,,CC(C)=O,,O=S(=O)([O-])[O-].[Mg+2],,val
US20040010007A1,COC(C)(OC)OC.Cc1nc(Oc2ccccc2)c(N)c(NCCCCCCl)c1C>>Cc1nc(Oc2ccccc2)c2nc(C)n(CCCCCCl)c2c1C,,C1CCOC1,CCOC(C)=O,Cl,c1ccncc1,val
US20120214762A1,CN(C)C(=O)c1n[nH]c2cc(I)ccc12.CNc1cc(Cl)nc(N)n1>>CNc1cc(-n2nc(C(=O)N(C)C)c3ccc(I)cc32)nc(N)n1,,CN(C)C=O,,[H-].[Na+],,val
US03995052,CC(N)=O.OCCC1=CCc2ccccc21.c1ccccc1>>CC(=O)NCCCC1(C)OCCC2=C1Cc1ccccc12,,c1ccccc1,,,,val
US20050227987A1,Cc1ccc2cc(N)ccc2n1.O=S(=O)(Cl)c1cc(Cl)ccc1Cl>>Cc1ccc2cc(NS(=O)(=O)c3cc(Cl)ccc3Cl)ccc2n1,,ClCCl,,c1ccncc1,O=C([O-])O.[Na+],val
US20010051733A1,Cc1ccc(C)c(CCC(=O)CCSCCC(=O)CCc2cc(C)ccc2C)c1>>Cc1ccc(C)c(CCC(O)CCSCCC(O)CCc2cc(C)ccc2C)c1,,CCO,,Cl,[BH4-].[Na+],val
US20040204427A1,CC(C)(C)[Si](C)(C)O[C@H]1CC[C@H](N=[N+]=[N-])C1>>CC(C)(C)[Si](C)(C)O[C@H]1CC[C@H](N)C1,O=[Pt],CCO,,[H][H],,val
US20110257174A1,O=C(CC(=O)c1cccc([N+](=O)[O-])c1O)c1cccnc1C(F)(F)F>>O=c1cc(-c2cccnc2C(F)(F)F)oc2c([N+](=O)[O-])cccc12,,CC(=O)O,,Cl,,val
US05922737,CCOC(=O)N1CCC(Nc2nc3ccccc3n2Cc2ccc(F)cc2)CC1>>Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc32)cc1,,Br,,,,val
US20090186870A1,Cc1ccc(Cl)c(C(N)=O)c1.O=C1CCC(=O)N1Br>>NC(=O)c1cc(CBr)ccc1Cl,,CC#N,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20090186886A1,NCCCCN1CCOCC1.[O-][n+]1nc(Cl)nc2cc3c(cc21)CCC3>>[O-][n+]1nc(NCCCCN2CCOCC2)nc2cc3c(cc21)CCC3,,COCCOC,,CCN(CC)CC,,val
US20100160309A1,CCCCOc1nccc2nc(C(C)=O)c3ccc(F)cc3c12.C[Mg]Br>>CCCCOc1nccc2nc(C(C)(C)O)c3ccc(F)cc3c12,,C1CCOC1,,,,val
US20020082260A1,CC(C)(C)OC(=O)C(CC1CCCCCC1)N=C(c1ccccc1)c1ccccc1>>NC(CC1CCCCCC1)C(=O)O,,CO,,Cl,,val
US20120196894A1,O[C@]12CCCC[C@@H]1N(Cc1ccccc1)CCC2Nc1ccccc1>>O[C@]12CCCC[C@@H]1NCCC2Nc1ccccc1,[Pd],CO,,,,val
US20120156793A1,Cc1c2ccccc2cc2ccccc12.O=C(Cl)C(=O)Cl>>Cc1c2ccccc2c2c3c(cccc13)C(=O)C2=O,,S=C=S,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20100093711A1,CC1(C)C(=O)Nc2ccccc2C1O>>CC1(C)C(=O)Nc2ccccc2C1=O,O=[Mn]=O,CN(C)C=O,ClCCl,,,val
US20020123499A1,O=C(O)C1(c2ccc(Cl)cc2)CCCC1.OCC1CCCNC1>>O=C(N1CCCC(CO)C1)C1(c2ccc(Cl)cc2)CCCC1,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20050288367A1,CNC(=O)COc1ccc(OCc2ccccc2)cc1>>CNC(=O)COc1ccc(O)cc1,[Pd],C1CCOC1,,,,val
US20090192147A1,CN.Nc1ccc2c(c1)C(=O)CO2.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CNC(=O)Nc1ccc2c(c1)C(=O)CO2,,ClCCl,,C1CCOC1,CCN(CC)CC,val
US20120172333A1,CCOC(=O)c1c(NC(=O)CC#N)cc(Cl)n1-c1ccc(C(C)=O)cc1>>CC(=O)c1ccc(-n2c(Cl)cc3[nH]c(=O)c(C#N)c(O)c32)cc1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20160214971A1,CS(N)(=O)=O.O=C(O)c1ccc(I)c(Br)c1>>CS(=O)(=O)NC(=O)c1ccc(I)c(Br)c1,CN(C)c1ccncc1,,,CCN=C=NCCCN(C)C,Cl,val
US20040242584A1,Fc1cccc(F)n1.[Li]c1ccccc1>>Fc1cccc(-c2ccccc2)n1,,C1CCOC1,,,,val
US20050065210A1,CI.COC(=O)[C@@H]1CC[C@@H](CNS(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1>>COC(=O)[C@@H]1CC[C@@H](CN(C)S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1,,CN(C)C=O,CO,[Na],,val
US20060223801A1,COC(=O)C(=O)NNC(=O)N1CCC(NC(=O)OC(C)(C)C)CC1>>COC(=O)c1nnc(N2CCC(NC(=O)OC(C)(C)C)CC2)o1,,ClCCl,,Cc1ccc(S(=O)(=O)Cl)cc1,,val
US20020026060A1,CC1(C)CC(C)(C)c2cc(CC(=O)O)ccc2O1.CCCCCI>>CCCCCC(C(=O)O)c1ccc2c(c1)C(C)(C)CC(C)(C)O2,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20040254178A1,CSc1nccc(C(C(=O)c2cccc(C(F)(F)F)c2)C(C)C(=O)C2CCN(C(=O)OCc3ccccc3)CC2)n1.NN>>CSc1nccc(-c2c(-c3cccc(C(F)(F)F)c3)nnc(C3CCN(C(=O)OCc4ccccc4)CC3)c2C)n1,,CCO,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US05763196,COC(=O)N1C(=O)C=CC1=O.NCCO>>O=C1C=CC(=O)N1CCO,,O=C([O-])O,[Na+],O=S(=O)(O)O,,val
US20080319188A1,CC(C)(C)O.O=C(Nc1ccc(Oc2ccnc(C(=O)O)c2)c(F)c1)OCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)Nc1cc(Oc2ccc(NC(=O)OCc3ccccc3)cc2F)ccn1,,CCCCCC,CCOCC,CCN(CC)CC,,val
US20120142717A1,C=Cc1ccc(Oc2ccc(C)c(F)c2)cc1.OO>>Cc1ccc(Oc2ccc(CCO)cc2)cc1F,,C1CCOC1,,B1C2CCCC1CCC2,[Na+].[OH-],val
US20060030613A1,CC(C)(C)c1ccc(CNCCc2cc(F)cc(C(F)(F)F)c2)cc1.O=C(O)c1cc(Cl)cc2cc[nH]c12>>CC(C)(C)c1ccc(CN(CCc2cc(F)cc(C(F)(F)F)c2)C(=O)c2cc(Cl)cc3cc[nH]c23)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20030225081A1,CC(=O)c1ccccn1.COc1cccc(C=O)c1>>COc1cccc(C=CC(=O)c2ccccn2)c1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20060252796A1,COc1ccccc1CN1CC(C)(C)C(Oc2ccc(C#N)c(C(F)(F)F)c2)C1=O>>CC1(C)CN(Cc2ccccc2O)C(=O)C1Oc1ccc(C#N)c(C(F)(F)F)c1,,O,,,,val
US20020165275A1,COC(=O)c1cc(O)cc(C(=O)OC)c1.OB(O)c1cccc2ccccc12>>COC(=O)c1cc(Oc2ccc3ccccc3c2)cc(C(=O)OC)c1,,ClCCl,,CCN(CC)CC,,val
US04329347,Cc1cc(C(C)(C)C)ccc1SCCCCOc1ccc2c(c1)CCC(=O)N2.OO>>Cc1cc(C(C)(C)C)ccc1S(=O)CCCCOc1ccc2c(c1)CCC(=O)N2,,CO,ClCCCl,,,val
US20140194349A1,CC(C)(C)OC(=O)[C@@H](N1CCN(Cc2ccc(F)cc2)C1=O)C(C)(C)C>>CC(C)(C)[C@@H](C(=O)O)N1CCN(Cc2ccc(F)cc2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130046013A1,CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CC)C(=O)NCCOC(=O)Nc1ccc(O)c(C(=O)OC)c1>>CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CC)C(=O)NCCOC(=O)Nc1ccc(O)c(C(=O)O)c1,,CO,,Cl,[Li+].[OH-],val
US20080242665A1,CC1(C)OB(c2ccc(N)nc2)OC1(C)C.O=Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1.OCCN1CCNCC1>>Nc1ccc(-c2nc(N3CCOCC3)c3sc(CN4CCN(CCO)CC4)cc3n2)cn1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140309208A1,CCOc1c(Nc2cccc(C(=O)N3CC[C@@H](O)C3)c2O)c(=O)c1=O.Cc1ccc(C(N)C2(C)COC2)o1>>Cc1ccc(C(Nc2c(Nc3cccc(C(=O)N4CC[C@@H](O)C4)c3O)c(=O)c2=O)C2(C)COC2)o1,,CO,,,,val
US20080058333A1,CN=C=O.C[C@@H](NC(=O)C(O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1ccccc1>>CNC(=O)NCCCC[C@H](NC(=O)OC(C)(C)C)C(O)C(=O)N[C@H](C)c1ccccc1,,C1CCOC1,,,,val
US20110183938A1,CCOC(=O)C(Cc1c[nH]c2nccc(Cl)c12)(NC(C)=O)C(=O)OCC.Cl>>Cl.NC(Cc1c[nH]c2nccc(Cl)c12)C(=O)O,,Cl,,,,val
US20160068559A1,CN(CCCN)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21.O=C=Nc1ccc(Cl)cc1>>CN(CCCNC(=O)Nc1ccc(Cl)cc1)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21,CCN(CC)CC,ClCCl,,,,val
US20110312935A1,CCOC(=O)c1cc([N+](=O)[O-])c(N)cc1F>>CCOC(=O)c1cc(N)c(N)cc1F,[Pd],CO,,,,val
US05556977,COC(=O)COc1ccccc1.O=C(Cl)CCCl>>COC(=O)COc1ccc(C(=O)CCCl)cc1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20110257196A1,COc1cc(C(=O)Cl)cc(OC)c1OC.O=S(=O)(c1ccccc1)n1ccnc1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12>>COc1cc(C(=O)c2cn(S(=O)(=O)c3ccccc3)c(-c3cn(S(=O)(=O)c4ccccc4)c4ccccc34)n2)cc(OC)c1OC,,C1CCOC1,,CCCCC,[Li]C(C)(C)C,val
US20130029969A1,C1CCNC1.O=c1[nH]c(CCl)nc2cc(Br)sc12>>O=c1[nH]c(CN2CCCC2)nc2cc(Br)sc12,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20070197577A1,CC(C)(C)OC(=O)NC(C(=O)NCc1ccccc1)c1ccc(-c2ccccc2)cc1.Cl>>Cl.NC(C(=O)NCc1ccccc1)c1ccc(-c2ccccc2)cc1,,C1COCCO1,,,,val
US20100240669A1,N#Cc1cc(F)ccc1Nc1cnc(CN)c(F)c1.O=C(NC1(C(=O)O)CC1)c1cncnc1>>N#Cc1cc(F)ccc1Nc1cnc(CNC(=O)C2(NC(=O)c3cncnc3)CC2)c(F)c1,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US05089507,CC1(C)CCC(Cl)(Cl)C(=O)NC1>>CC1(C)CCC(Cl)C(=O)NC1,[Pd],CC(=O)O,,[H][H],,val
US20110263526A1,CC(Cl)OC(=O)Cl.COc1ccc2cc(C(C)C(=O)OCC(=O)OCCCO)ccc2c1>>COc1ccc2cc([C@H](C)C(=O)OCC(=O)OCCCOC(=O)OC(C)Cl)ccc2c1,,ClCCl,,c1ccncc1,,val
US20110136764A1,CCOC(=O)Cn1cc(C)c(=O)c2c([N+](=O)[O-])cccc21>>CCOC(=O)Cn1cc(C)c(=O)c2c(N)cccc21,[Pd],CCO,ClCCl,,,val
US20090270351A1,COP(=O)(OC)C(F)c1ccc(C(=O)OCc2ccccc2)cc1>>COP(=O)(OC)C(F)c1ccc(C(=O)O)cc1,[Pd],CO,,,,val
US20050023507A1,CCCCN(CCCC)c1ccc(/C=C/C=C/c2sccc2O[Si](C)(C)C(C)(C)C)cc1.CN(C)C=O>>CCCCN(CCCC)c1ccc(/C=C/C=C/c2sc(C=O)cc2O[Si](C)(C)C(C)(C)C)cc1,,C1CCOC1,,O,[Li]CCCC,val
US20030207865A1,BrC1CCCC1.Cc1cc([N+](=O)[O-])ccc1N=C1NC2(CCCC2)CS1>>Cc1cc([N+](=O)[O-])ccc1N=C1SCC2(CCCC2)N1C1CCCC1,,CN(C)C=O,O,Cl,[Na+].[OH-],val
US05162546,C#C[Si](C)(C)C.CC1CC(C)(C)c2cc(Br)ccc2S1>>CC#CC1CC(C)(C)c2cc([Si](C)(C)C)ccc2S1,Cl[Pd]Cl,,,CCN(CC)CC,,val
US20080193481A1,CC(=O)S.CCCC=CO[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]1O[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O>>CCCCC(O[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]1O[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O)C(C)=S,,ClCCl,,,,val
US20140178771A1,Nc1c(Br)cc(Br)cc1[N+](=O)[O-]>>Nc1cc(Br)cc(Br)c1N,,CCO,,O,,val
US20150038488A1,CN(CCO)c1ccc(Br)cc1N=O>>CN(CCO)c1ccc(Br)cc1N,,C1CCOC1,,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US04578462,CCN(CC)C/C=C(\C)C(OC)OC>>CCN(/C=C/[C@H](C)C(OC)OC)CC,,C1CCOC1,,,,val
US04235904,COc1ccccc1N1CCN(CCC(O)C(=O)c2ccc(F)cc2)CC1.ClC(Cl)Cl.O=C(Cl)Cl>>COc1ccccc1N1CCN(CCc2oc(=O)oc2-c2ccc(F)cc2)CC1.Cl.Cl,,Cc1ccccc1,ClC(Cl)Cl,,,val
US20090136448A1,Nc1ccccc1O.O=C(Cl)c1cc(Br)co1>>Brc1coc(-c2nc3ccccc3o2)c1,,C1COCCO1,,[Na+].[OH-],,val
US20070117854A1,C=O.CC(C)(C)c1cc[nH]n1>>CC(C)(C)c1ccn(CO)n1,,CC(C)=O,,CCN(CC)CC,,val
US20100311693A1,Br[Cu]Br.Nc1nc2c(Br)cccn2n1>>Brc1nc2c(Br)cccn2n1,Br[Cu]Br,,,Br,,val
US04772613,Nc1ccccc1.O=C(Cl)Cc1ccc(Cl)cc1Cl>>O=C(Cc1ccc(Cl)cc1Cl)Nc1ccccc1,,CCOCC,,CCN(CC)CC,O,val
US20100168418A1,COc1cc(-c2ccncc2)c2ncc(=O)n(CCN3CCC(NC(=O)OC(C)(C)C)CC3)c2c1>>COc1cc(-c2ccncc2)c2ncc(=O)n(CCN3CCC(N)CC3)c2c1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US03960892,COc1ccc(C=O)c(C(=O)O)c1.O=C1CSC(=S)N1>>COc1ccc(C=C2SC(=S)NC2=O)c(C(=O)O)c1,,O,,CC(=O)O,CC(=O)[O-].[Na+],val
US05830869,C=CCBr.COC(=O)C[C@](C)(CC(C)C)NC(=O)OCc1ccccc1>>C=CC[C@H](C(=O)OC)[C@](C)(CC(C)C)NC(=O)OCc1ccccc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20160108039A1,CCC1C(=O)N2CCC2CN1C(=O)OCc1ccccc1>>CCC1NCC2CCN2C1=O,[Pd],CO,,,,val
US20040132746A1,CC(=O)Cl.Cc1cc(C)c(C#N)[nH]1>>CC(=O)c1c(C)[nH]c(C#N)c1C,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20120196884A1,CN(c1ccc(NC(=O)Nc2ccccc2)cc1)S(=O)(=O)c1ccc(Br)s1.Cn1nccc1B1OC(C)(C)C(C)(C)O1>>CN(c1ccc(NC(=O)Nc2ccccc2)cc1)S(=O)(=O)c1ccc(-c2ccnn2C)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US06258508B1,C[C@H](CCC(=O)OC(C)(C)C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](OC(=O)C5CC6C=CC5C6)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C.O=C1C=CC(=O)O1>>C[C@H](CCC(=O)OC(C)(C)C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](OC(=O)C5CC6C=CC5C6)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C.O=C1C=CC(=O)O1,,Cc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US05134128,CCCCCCCCCCCC(=O)Cl.OCc1ccoc1>>CCCCCCCCCCCC(=O)OCc1ccoc1,,C1CCOC1,,c1ccncc1,,val
US20060079533A1,CC(C)(C)OC(=O)N1CCC(c2ncc(OCCCOCc3ccccc3)cn2)C(OCc2ccc3ccccc3c2)C1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.c1ccc(COCCCOc2cnc(C3CCNCC3OCc3ccc4ccccc4c3)nc2)cc1,,ClCCl,,,,val
US20070249589A1,CI.COc1ccc(COc2ccc(C)nc2CO)cc1>>COCc1nc(C)ccc1OCc1ccc(OC)cc1,,C1CCOC1,,[H-].[Na+],,val
US05434186,CC(=O)c1ccc(O)c(CCCc2ccccc2)c1O.COC(=O)CCCCCOc1cccc(CCCCCCOS(C)(=O)=O)c1CCC(=O)OC>>COC(=O)CCCCCOc1cccc(CCCCCCOc2ccc(C(C)=O)c(O)c2CCCc2ccccc2)c1CCC(=O)OC,,CC#N,CCOCC,[I-].[K+],O=C([O-])O.[Na+],val
US20090176823A1,CNC(=O)OCc1ccc(Cl)c(CN(C(=O)OC(C)(C)C)C2CC2)c1>>CNC(=O)OCc1ccc(Cl)c(CNC2CC2)c1,,ClCCl,,Cl,,val
US20090156610A1,Cc1ccc(S(=O)(=O)OC2CCN(C(=O)OC(C)(C)C)CC2)cc1.O=Cc1c(O)ccc(Cl)c1F>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(Cl)c(F)c2C=O)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110184015A1,COC(=O)c1cccc2c1-n1cccc1C2=O>>O=C(O)c1cccc2c1-n1cccc1C2=O,,CO,O,[Li+].[OH-],,val
US05977105,CC(=O)OC(C)=O.Oc1cccc(-c2ccc(OC[C@H](O)CCc3cccnc3)cc2)c1>>CC(=O)Oc1cccc(-c2ccc(OC[C@H](O)CCc3cccnc3)cc2)c1,,ClCCl,,CCN(CC)CC,O,val
US20070093521A1,CCOC(=O)c1ccc2nc(NC3CCN(Cc4cc(OCC)c(F)c(OCC)c4)CC3)sc2c1.CCOc1cc(C=O)cc(OCC)c1Cl>>CCOC(=O)c1ccc2nc(NC3CCN(Cc4cc(OCC)c(Cl)c(OCC)c4)CC3)sc2c1,,CC(=O)O,CCO,CCN(C(C)C)C(C)C,[BH3-]C#N.[Na+],val
US20110207711A1,CCC(=O)/C(=C/N(C)C)C(=O)OC.NNc1ccccc1>>CCc1c(C(=O)OC)cnn1-c1ccccc1,,CCO,,,,val
US20110319392A1,COC(=O)c1ccnc(N)c1.O=S(=O)(Cl)c1c(F)cccc1F>>COC(=O)c1ccnc(NS(=O)(=O)c2c(F)cccc2F)c1,,c1ccncc1,,O,,val
US20080146557A1,Fc1ccccn1.O=C1OC2(CCN(C(=O)c3c[nH]c4cc(Cl)ccc34)CC2)c2ccc(F)cc21>>O=C1OC2(CCN(C(=O)c3cn(-c4ccccn4)c4cc(Cl)ccc34)CC2)c2ccc(F)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20110015207A1,COc1ccc(N2CCNCC2)cc1C(F)(F)F.COc1ccc(NC(=O)CBr)c([N+](=O)[O-])c1>>COc1ccc(NC(=O)CN2CCN(c3ccc(OC)c(C(F)(F)F)c3)CC2)c([N+](=O)[O-])c1,,CCO,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US05196454,CC(=O)Nc1cccc2c1CCC(=O)C2.C[C@@H](N)c1ccccc1>>CC(=O)Nc1cccc2c1CCC(NC(C)c1ccccc1)C2,,CO,,Cl,[BH3-]C#N.[Na+],val
US20160158207A1,O=[N+]([O-])c1cc(C(F)(F)F)c(Br)cc1OCCCl>>Nc1cc(C(F)(F)F)c(Br)cc1OCCCl,[Fe],CC(=O)O,,,,val
US20150353553A1,C[C@H]1CC[C@H](Cn2c(-c3nccs3)nc3nc(C#N)nc(N[C@H](C)C4CCC4)c32)CC1.O.[OH-]>>C[C@H]1CC[C@H](Cn2c(-c3nccs3)nc3nc(C(=O)O)nc(N[C@H](C)C4CCC4)c32)CC1,,O,,CCO,,val
US04367238,CCCC(C(=O)O)c1cccc(Oc2ccccc2C)c1OC>>CCCC1C(=O)Oc2c(Oc3ccccc3C)cccc21,,CC(=O)OC(C)=O,,I,,val
US20050165006A1,C=C[Sn](CCCC)(CCCC)CCCC.O=CN1CCN(c2cc(Br)c3cc([N+](=O)[O-])ccc3n2)CC1>>C=Cc1cc(N2CCNCC2)nc2ccc([N+](=O)[O-])cc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20100168094A1,CCOC(=O)Cl.COC(=O)C1CNc2cc(C#N)ccc2O1>>CCOC(=O)N1CC(C(=O)OC)Oc2ccc(C#N)cc21,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20030050458A1,c1ccc(C(SCCCSCCCSCCOCCOCCSCCCSCCCSC(c2ccccc2)(c2ccccc2)c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>SCCCSCCCSCCOCCOCCSCCCSCCCS,,ClCCl,O=C(O)C(F)(F)F,,,val
US20110263598A1,C=CB1OC(C)(C)C(C)(C)O1.O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(I)n[nH]c2c1>>C=Cc1n[nH]c2cc([C@@H]3C[C@@]34C(=O)Nc3ccccc34)ccc12,,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20050277668A1,C1CCOC1.CCN(C(C)C)C(C)C.CCOc1ccc(NC2CCN([C@H](C)CC#N)CC2)cc1.Cl.O=C(Cl)c1cccnc1>>CCOc1ccc(N(C(=O)c2cccnc2)C2CCN([C@H](C)CC#N)CC2)cc1.ClCc1cccnc1,,C1CCOC1,,,,val
US20070244088A1,C1CNCCN1.CCOC(=O)c1cnc(Cl)c(Br)c1>>CCOC(=O)c1cnc(N2CCNCC2)c(Br)c1,,CCO,CCOC(C)=O,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20030199440A1,CC(C)(N)C(N)=O.O=S(=O)(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>CC(C)(NS(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1)C(N)=O,,ClCCl,,CCN(CC)CC,,val
US20100331334A1,COC(=O)c1cc2c(C)ncnc2c(F)c1Nc1ccc(I)cc1F>>Cc1ncnc2c(F)c(Nc3ccc(I)cc3F)c(C(=O)O)cc12,,C1CCOC1,O,[Li+].[OH-],,val
US06596750B2,NC(=O)c1cc(Cl)ccc1O.O=C(O)c1cc(Cl)ccc1O>>O=c1nc(-c2cc(Cl)ccc2O)oc2ccc(Cl)cc12,,Cc1ccccc1C,,O=S(Cl)Cl,c1ccncc1,val
US20140255344A1,COC(=O)N[C@H]1CCC(=O)N2CCC[C@@H](c3ncc(-c4ccc(B5OC(C)(C)C(C)(C)O5)cc4)[nH]3)N2C1=O.Clc1cnc2cc(Br)ccc2n1>>COC(=O)N[C@H]1CCC(=O)N2CCC[C@@H](c3ncc(-c4ccc(-c5cnc6cc(Br)ccc6n5)cc4)[nH]3)N2C1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US06329421B1,CS(=O)(=O)c1ccc(-c2c(-c3ccc(F)cc3)sc(C(=O)O)c2CO)cc1>>CS(=O)(=O)c1ccc(-c2c(-c3ccc(F)cc3)sc3c2COC3=O)cc1,,ClCCl,,,,val
US20060270632A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.OCCC1(CCO)CCCCC1>>CC(C)(C)[Si](OCCC1(CCO)CCCCC1)(c1ccccc1)c1ccccc1,,ClCCl,,[Cl-].[NH4+],,val
US20070293516A1,CCOc1cc(C(O)=C(C#N)C#N)ccc1OC.COS(=O)(=O)OC>>CCOc1cc(C(OC)=C(C#N)C#N)ccc1OC,,O,,C1COCCO1,O=C([O-])O.[Na+],val
US20070054884A1,N#Cc1cc(Cl)ccc1Oc1ccc(F)cc1O.NC(=O)CCC(=O)NBr>>N#Cc1cc(Cl)ccc1Oc1cc(Br)c(F)cc1O,,ClCCl,,,,val
US20070232645A1,COC(=O)c1ccc(-c2ccccc2)c([N+](=O)[O-])c1>>COC(=O)c1ccc(-c2ccccc2)c(N)c1,,CCO,,,,val
US20120184531A1,Brc1ccc2c3c(oc2c1)CCCNC3.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCCc2oc3cc(Br)ccc3c2C1,,ClCCl,,CCN(CC)CC,,val
US04474977,CC(=O)OC(C)=O.CCCCCCCCNC(CC)C(O)c1ccc(SC(C)C)cc1.Cl>>CCCCCCCCNC(CC)C(OC(C)=O)c1ccc(SC(C)C)cc1.Cl,,CC#N,,,,val
US20060178532A1,CC(C)N(NC(=O)c1ccccc1)C(=O)COc1ccc(F)cc1Br.COc1ccc(B(O)O)cc1>>COc1ccc(-c2cc(F)ccc2OCC(=O)N(NC(=O)c2ccccc2)C(C)C)cc1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20080021217A1,COC(=O)c1cc(-c2ccncc2)n[nH]1>>OCc1cc(-c2ccncc2)n[nH]1,,CO,ClCCl,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20080125441A1,NCCSCCO.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1CCSCCO,,Cc1ccccc1,,,,val
US04962110,CSc1nccc(=O)[nH]1.C[C@@H]1CC(=O)NN=C1c1ccc(N)cc1>>C[C@@H]1CC(=O)NN=C1c1ccc(Nc2nc(=O)cc[nH]2)cc1,,c1ccncc1,,,,val
US20140256700A1,CCOC(=O)c1ccc2c(c1)c1c(C(=O)OC(C)(C)C)cc(-c3c(C)noc3C)cc1n2Cc1ccc(F)cc1>>Cc1noc(C)c1-c1cc(C(=O)OC(C)(C)C)c2c3cc(C(=O)O)ccc3n(Cc3ccc(F)cc3)c2c1,,CO,,C1CCOC1,[Na+].[OH-],val
US20040006067A1,Cn1ccn(-c2ccccc2C2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@@H]3Cc4ccccc4CN3C(=O)OC(C)(C)C)CC2)c1=O>>Cn1ccn(-c2ccccc2C2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@@H]3Cc4ccccc4CN3)CC2)c1=O,,CCOC(C)=O,,Cl,,val
US20090286985A1,Brc1c2ccccc2c(-c2ccc(-c3nc4ccccc4o3)cc2)c2ccccc12.OB(O)c1ccc2ccccc2c1>>c1ccc2cc(-c3c4ccccc4c(-c4ccc(-c5nc6ccccc6o5)cc4)c4ccccc34)ccc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20060173018A1,CC(C)(C)OC(=O)N[C@@H]1CCNC1.Cc1ccc2c(Cl)nc(-c3c(O)cccc3F)nc2c1>>Cc1ccc2c(N3CC[C@@H](NC(=O)OC(C)(C)C)C3)nc(-c3c(O)cccc3F)nc2c1,,ClCCl,,CCN(CC)CC,,val
US20050137171A1,CC(C)(C)OC(=O)n1nc(-c2cc3ccccc3n2C(=O)OC(C)(C)C)c2cc(OCc3ccccc3)ccc21>>CC(C)(C)OC(=O)N1c2ccccc2CC1c1nn(C(=O)OC(C)(C)C)c2ccc(O)cc12,[Pd],CCO,,O=C[O-].[NH4+],,val
US20150299230A1,CCS(=O)(=O)c1cc([N+](=O)[O-])c(C(=O)N(C)CCOP(=O)(OC(C)(C)C)OC(C)(C)C)cc1N(CCBr)CCBr>>CCS(=O)(=O)c1cc([N+](=O)[O-])c(C(=O)N(C)CCOP(=O)(O)O)cc1N(CCBr)CCBr,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120010241A1,O=S(=O)(Oc1cccc2c1c(C(F)(F)F)nn2S(=O)(=O)C(F)(F)F)C(F)(F)F.OB(O)c1cnc2ccccc2c1>>FC(F)(F)c1n[nH]c2cccc(-c3cnc4ccccc4c3)c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20100069388A1,C[C@@H](Nc1ncc(/C=C/C(=O)NOC2CCCCO2)cc1Cl)C(=O)NCC1CCCCC1>>C[C@@H](Nc1ncc(/C=C/C(=O)NO)cc1Cl)C(=O)NCC1CCCCC1,,CCO,,Cl,,val
US20090281060A1,CS(=O)(=O)Cl.OCc1nc(-c2ccncc2)no1>>CS(=O)(=O)OCc1nc(-c2ccncc2)no1,,ClCCl,,CCN(CC)CC,O,val
US20130096124A1,CCC(=O)Cl.Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)sc1C(C)N>>CCC(=O)NC(C)c1sc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150175601A1,COc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1N.Clc1ncc2cccc(Br)c2n1>>COc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1ncc2cccc(Br)c2n1,,CCCCO,,O=C(O)C(F)(F)F,,val
US20020102590A1,C#C[Si](CC)(CC)CC.Oc1ccc(I)cc1>>CC[Si](C#Cc1ccc(O)cc1)(CC)CC,[Cu]I,CN(C)C=O,,CCN(CC)CC,,val
US20130090386A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H]1C[C@H]1c1ccc(OCc2ccccc2)cc1>>CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(OCc2ccccc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20160145192A1,O=C(OCCCCO)c1ccc([N+](=O)[O-])cc1.O=[N+]([O-])O>>O=C(OCCCCO[N+](=O)[O-])c1ccc([N+](=O)[O-])cc1,,CC(=O)OC(C)=O,,,,val
US20050038101A1,CC(C)(C)CC(=O)Cl.CCOC(=O)c1cc2cc(N)ccc2[nH]1>>CCOC(=O)c1cc2cc(NC(=O)CC(C)(C)C)ccc2[nH]1,,C1CCOC1,,CCN(CC)CC,O,val
US20140350005A1,CC(C)(C)OC(=O)c1ccccc1CN1CN(c2ccc(F)cc2)C2(CCN(CCCn3c(=O)n(C4CC4)c4ccccc43)CC2)C1=O>>O=C(O)c1ccccc1CN1CN(c2ccc(F)cc2)C2(CCN(CCCn3c(=O)n(C4CC4)c4ccccc43)CC2)C1=O,,C1COCCO1,Cl,,,val
US20100324106A1,Oc1cc(F)cc2c1ccn2-c1ccc(OCc2ccccc2)cc1>>Oc1ccc(-n2ccc3c(O)cc(F)cc32)cc1,[Pd],CCO,,,,val
US20050070585A1,CC/C(=C/CN(OC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1ccc2c(Cc3ccccc3)c(CC)oc2c1>>CC/C(=C/CNO)c1ccc2c(Cc3ccccc3)c(CC)oc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110105462A1,C=CCN.Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(F)cc3O2)cc1>>C=CCNCC1COc2c(F)cc(F)cc2O1,,CC#N,,,,val
US20110306604A1,CCOC(=O)C(C)(C)CC[C@H](NCc1cnc2cc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21)c1cc(F)cc(F)c1>>CC1(C)CC[C@@H](c2cc(F)cc(F)c2)N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C1=O,,ClC(Cl)Cl,,,,val
US20060252931A1,C1CN(C2CCOCC2)CCN1.Cc1cc(C[C@@H](OC(=O)N2CCC(n3nc(-c4ccccc4)[nH]c3=O)CC2)C(=O)O)cc(C)c1O>>Cc1cc(C[C@@H](OC(=O)N2CCC(n3nc(-c4ccccc4)[nH]c3=O)CC2)C(=O)N2CCN(C3CCOCC3)CC2)cc(C)c1O,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20090253687A1,Cc1ccccc1CC(=O)O.O=C(Cl)C(=O)Cl>>Cc1ccccc1CC(=O)Cl,CN(C)C=O,C1CCOC1,,,,val
US20090226398A1,COc1ccc(-c2ccc(C)nn2)c(C(F)(F)F)c1.O=c1n(Cl)c(=O)n(Cl)c(=O)n1Cl>>COc1ccc(-c2ccc(CCl)nn2)c(C(F)(F)F)c1,,ClCCCl,,,,val
US20090253669A1,N#CC1(c2cccnc2)CCC(=O)CC1.OCCO>>N#CC1(c2cccnc2)CCC2(CC1)OCCO2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20110034507A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1CO.COC(=O)c1cccc(-c2nc3ccc(O)cc3s2)c1>>COC(=O)c1cccc(-c2nc3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)cc3s2)c1,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160046624A1,CC(C)CC=O.CC(C)Oc1cnc2c(c1)c(=O)n(CCCOC1CCCCO1)c(=O)n2C>>CC(C)CC(O)c1c(OC(C)C)cnc2c1c(=O)n(CCCOC1CCCCO1)c(=O)n2C,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20040039038A1,NCCc1ccccc1.O=C1NC(=O)C(=Cc2ccc(-c3cccc(C(=O)O)c3)cc2)S1>>CN(Cc1ccccc1)C(=O)c1cccc(-c2ccc(C=C3SC(=O)NC3=O)cc2)c1,,CN(C)C=O,O,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20060281755A1,CC(C)Oc1ccc(NC(=O)N2CCN(c3ncnc(N)c3C=O)CC2)cc1.NOCCN1CCOCC1>>CC(C)Oc1ccc(NC(=O)N2CCN(c3ncnc(N)c3C=NOCCN3CCOCC3)CC2)cc1,,CO,,Cl,Cl,val
US20050277662A1,COC(=O)c1cc2c(COCCN3CCCC3=O)cn(Cc3ccc(F)cc3)c2cn1>>O=C(O)c1cc2c(COCCN3CCCC3=O)cn(Cc3ccc(F)cc3)c2cn1,,CO,,Cl,[Li+].[OH-],val
US20130023541A1,CCc1cccc(C=O)c1.CN[C@H]1CCN(c2ncccc2C(=O)OC(C)C)C1>>CCc1cccc(CN(C)[C@H]2CCN(c3ncccc3C(=O)OC(C)C)C2)c1,,C1CCOC1,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US06025496,CI.O=P(CCCl)(c1ccccc1)c1ccccc1.c1c[nH]cn1>>C[n+]1ccn(CCP(=O)(c2ccccc2)c2ccccc2)c1.[I-],,CCO,Cc1ccccc1,CCN(CC)CC,,val
US05171851,Cc1cn(-c2ccc(N)c(C)c2)cn1.ClI>>Cc1cn(-c2cc(C)c(N)c(I)c2)cn1,,CC(=O)O,,O=C([O-])O.[Na+],,val
US20110275762A1,NC(=O)C1Oc2ccccc2C1N.O=C(Cl)C(=O)Cl>>O=c1[nH]c(=O)c2oc3ccccc3c2[nH]1,,Cc1ccccc1,,,,val
US05767131,CCCC(=O)CC(=O)OCCC#N.COC(=O)/C=C(/C)N.O=Cc1ccc(Cl)cc1>>CCCC1=C(C(=O)O)C(c2ccc(Cl)cc2)C(C(=O)OC)=C(C)N1,,CC(C)O,,,,val
US20120202785A1,C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)c(Br)c2n1C.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)c(-c3cnn(C)c3)c2n1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US07022825B2,C[C@H](C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1)[C@@H](O)C#C[Si](C)(C)C>>C#C[C@H](O)[C@H](C)C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20120264737A1,Cc1cc(C)c(-c2nc3c([nH]2)CN(C(=O)OC(C)(C)C)CC3)cc1C(=O)N1CCC(c2ccc(C#N)cc2)CC1>>Cc1cc(C)c(-c2nc3c([nH]2)CNCC3)cc1C(=O)N1CCC(c2ccc(C#N)cc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US03995050,CN=C=O.Cc1cnc(Nc2ccccc2)n1-c1ccccc1>>CNC(=O)N(c1ccccc1)c1ncc(C)n1-c1ccccc1,,c1ccccc1,,,,val
US20130131034A1,CC(C)(C)OC(=O)N[C@@H]1CCCN([C@H]2c3cccnc3C[C@@H]2O)C1.N#Cc1ccc(O)c(Cl)c1>>N#Cc1ccc(O[C@@H]2c3cccnc3C[C@H]2N2CCC[C@@H](N)C2)c(Cl)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150361081A1,COc1ccc(CN2CCn3nc(CO)cc3C2=O)cc1.CS(=O)(=O)Cl>>COc1ccc(CN2CCn3nc(COS(C)(=O)=O)cc3C2=O)cc1,,ClCCl,O,CCN(CC)CC,,val
US20090264445A1,COC(=O)[C@H](CC1CCCCC1)N1CC(Oc2ccccc2)=CC1=O>>O=C(O)[C@H](CC1CCCCC1)N1CC(Oc2ccccc2)=CC1=O,,C1CCOC1,O,[Li+].[OH-],,val
US20100324068A1,CCOC(=O)Cc1cc(Cl)c(O)cc1C.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)Cc1cc(Cl)c(OS(=O)(=O)C(F)(F)F)cc1C,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20070197531A1,N[C@@H]1CC[C@@H](CCN2CCC(C(=O)c3ccc(F)cc3)CC2)CC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.c1ccc2c(c1)CCN2>>O=C(c1ccc(F)cc1)C1CCN(CCC2CCC(NC(=O)N3CCc4ccccc43)CC2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120202785A1,C[C@H](Nc1ncnc2c1ncn2C1CCCCO1)c1nc2ccc(F)c(C3CC3)c2n1-c1ccccn1>>C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)c(C3CC3)c2n1-c1ccccn1,,CO,Cl,,,val
US20130331419A1,CCOC(=O)c1noc(C(CC)(c2ccc(Cl)cc2)n2ncc3c(NS(C)(=O)=O)cccc32)n1.N>>CCC(c1ccc(Cl)cc1)(c1nc(C(N)=O)no1)n1ncc2c(NS(C)(=O)=O)cccc21,,CO,,,,val
US20120115862A1,CC(=O)Nc1cccc(OCc2cc([N+](=O)[O-])ccc2C(=O)O)c1>>CC(=O)Nc1ccc2c(c1)OCc1cc([N+](=O)[O-])ccc1C2=O,,O=S1(=O)CCCC1,,,,val
US20100029650A1,OCC1CCN(c2ncc(F)cn2)CC1>>O=CC1CCN(c2ncc(F)cn2)CC1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20150344423A1,CCOC(=O)c1cc(-c2ccc(S(=O)(=O)NC(C)(C)C)c(Cl)c2Cl)n(CC2CCCCC2)n1.O=C1CCC(=O)N1Cl>>CCOC(=O)c1nn(CC2CCCCC2)c(-c2ccc(S(=O)(=O)NC(C)(C)C)c(Cl)c2Cl)c1Cl,,CC#N,,,,val
US20030144333A1,CCOC(=O)C(=O)c1sc(Cl)c(Cl)c1Cl>>O=C(O)C(=O)c1sc(Cl)c(Cl)c1Cl,,CC(C)=O,O,Cl,,val
US20160262395A1,CC(C)(N)C#N.O=C(Cl)c1ccc(Cl)nn1>>CC(C)(C#N)NC(=O)c1ccc(Cl)nn1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US05304560,Br.COc1ccc2c(=O)[nH]c(=O)n(CCCCN3CC=C(c4ccccc4)CC3)c2c1>>Br.O=c1[nH]c(=O)n(CCCCN2CC=C(c3ccccc3)CC2)c2cc(O)ccc12,,CC(=O)O,,,,val
US20090253725A1,CC(=O)NCC1=NC2(CCN(C(=O)OC(C)(C)C)CC2)C(=O)N1.O=C(O)C(F)(F)F>>CC(=O)NCC1=NC2(CCNCC2)C(=O)N1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20130150401A1,CS(=O)(=O)OCC1(C(F)(F)F)CC1.CS(=O)(=O)c1ccc(-c2cc3c(cn2)OC(C2CCNCC2)C3)cc1>>CS(=O)(=O)c1ccc(-c2cc3c(cn2)OC(C2CCN(CC4(C(F)(F)F)CC4)CC2)C3)cc1,,CN1CCCC1=O,,[I-].[K+],,val
US20110059957A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCN(c2ccc(CCc3ccc(CO)cc3)nc2)CC1>>CC(=O)N1CCN(c2ccc(CCc3ccc(CO)cc3)nc2)CC1,,C1CCOC1,ClCCl,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20090197935A1,Cn1ncc(Br)c1-c1cc(N)ccc1OCC(C)(C)[N+](=O)[O-].O=C(Cl)c1cccc(Br)c1>>Cn1ncc(Br)c1-c1cc(NC(=O)c2cccc(Br)c2)ccc1OCC(C)(C)N,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160096827A1,O=[N+]([O-])c1ccc(N2CCN(C3COC3)CC2)c(OC(F)F)c1>>Nc1ccc(N2CCN(C3COC3)CC2)c(OC(F)F)c1,[Pd],CCO,CCOC(C)=O,,,val
US20100305096A1,O=Cc1nc2c(N3CCOCC3)nc(Cl)nc2s1.O=S1(=O)CCN(C2CNC2)CC1>>O=S1(=O)CCN(C2CN(Cc3nc4c(N5CCOCC5)nc(Cl)nc4s3)C2)CC1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120190677A1,CC1(C)CC(c2cccc(N3CCOCC3)c2)Nc2ccc(C(=O)O)nc21.CS(N)(=O)=O>>CC1(C)CC(c2cccc(N3CCOCC3)c2)Nc2ccc(C(=O)NS(C)(=O)=O)nc21,,CN(C)C=O,O,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20140283218A1,CC(=O)c1cnc(-c2cccnc2)s1.NO>>CC(=NO)c1cnc(-c2cccnc2)s1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20050130954A1,Clc1ccnc2[nH]ccc12.c1ccc(CN2CCNCC2)cc1>>c1ccc(CN2CCN(c3ccnc4[nH]ccc34)CC2)cc1,,[Na+],[OH-],,,val
US04827004,CC(C)=CCC/C(C)=C\CC/C(C)=C\COC1CCCCO1.O>>C=C(C)C(O)CC/C(C)=C\CC/C(C)=C\COC1CCCCO1,,COCCOC,,O=C1CCC(=O)N1Br,,val
US05658907,NCCc1ccccc1Cl.S=C(Nc1ccccn1)n1ccnc1>>S=C(NCCc1ccccc1Cl)Nc1ccccn1,,CN(C)C=O,,CCOC(C)=O,,val
US20090203750A1,CCOC(=O)[C@@H]1C[C@H]1c1cccc(Br)c1>>O=C(O)[C@@H]1C[C@H]1c1cccc(Br)c1,,CO,,O,[K+].[OH-],val
US20060205794A1,O=S(=O)(O)c1ccc(Cl)cc1.O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)C1CCCC1>>O=S(=O)([O-])c1ccc(Cl)cc1.O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)C1CCCC1,,CC(C)O,,,,val
US20160158377A1,CC(C)(C)OC(=O)N1CCc2c(O)cccc2C1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCc2c(O)ccc(Br)c2C1,,CN(C)C=O,,,,val
US20150376189A1,COc1nccc2oc(-c3cnc4ccc(Cl)nn34)cc12.C[C@@H](O)C(N)=O>>COc1nccc2oc(-c3cnc4ccc(NC(=O)[C@@H](C)O)nn34)cc12,,CN(C)C=O,,[H-].[Na+],,val
US20100256113A1,Cc1c(/C=C/C2CCN(C(=O)OCc3ccccc3)CC2)nc2ccccc2c1OCc1ccccc1>>Cc1c(CCC2CCNCC2)[nH]c2ccccc2c1=O,[Pd],CCO,,C1CCOC1,,val
US20080214601A1,Cl.O=C(N[C@@H]1CN2CCC1CC2)c1cccc2oc(C3CCC3)nc12>>Cl.O=C(N[C@@H]1CN2CCC1CC2)c1cccc2oc(C3CCC3)nc12,,CCOCC,CO,,,val
US20070135452A1,O=P(Cl)(Cl)Cl.O=[N+]([O-])c1cc(F)cc([N+](=O)[O-])c1O>>O=[N+]([O-])c1cc(F)cc([N+](=O)[O-])c1Cl,,CN(C)C=O,,,,val
US20130079321A1,Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ncc2N)c1N1CCC(NC(=O)OC(C)(C)C)CC(F)(F)C1>>Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ncc2N)c1N1CCC(N)CC(F)(F)C1,,C1COCCO1,,Cl,,val
US06307056B1,COc1cc[nH]c1/C=C1\C(=O)Nc2ccc([N+](=O)[O-])c(-c3ccc(O)cc3)c21>>COc1cc[nH]c1/C=C1\C(=O)Nc2ccc(N)c(-c3ccc(O)cc3)c21,[Zn],CO,O,[Cl-].[NH4+],,val
US05194442,N#Cc1ccc2c(c1)C(O)CCCO2>>N#Cc1ccc2c(c1)C=CCCO2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20070043065A1,Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(OCCN3CCCCC3)cc2c1=O.Cc1ccc(S(=O)(=O)O)cc1>>Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(OCCN3CCCCC3)cc2c1=O.Cc1ccc(S(=O)(=O)O)cc1,,CCOC(C)=O,,,,val
US20100273770A1,COC(=O)c1cc(Br)ccc1OCC(CO)NC(=O)OC(C)(C)C>>O=C1NC(CO)COc2ccc(Br)cc21,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US06204264B1,CN(C)CCCN.Cc1ccc(Cl)c([N+](=O)[O-])c1>>Cc1ccc(NCCCN(C)C)c([N+](=O)[O-])c1,,Cc1ccccc1,,,,val
US20040087582A1,COC(=O)C(Nc1cccc(C#N)c1)c1ccccc1>>N#Cc1cccc(NC(C(=O)O)c2ccccc2)c1,,CO,,[Na+].[OH-],,val
US20160016935A1,COc1ccc(CO)cc1.Fc1ccnc(F)c1>>COc1ccc(COc2ccnc(F)c2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20080020987A1,C1CCNC1.COc1ccc(C=O)c(F)c1.Cc1cc(=O)[nH]n1C(C)C>>COc1ccc(C(c2c(C)n(C(C)C)[nH]c2=O)N2CCCC2)c(F)c1,,CC#N,,CC(=O)O,,val
US20150291553A1,CC1(C)OB(c2ccnc(Cl)c2)OC1(C)C.COC(=O)c1cccnc1Br>>COC(=O)c1cccnc1-c1ccnc(Cl)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20140288185A1,CI.CN[C@]12CCC[C@@]1(C)[C@@H]1CC[C@H]2C1.Cl>>CN(C)[C@]12CCC[C@@]1(C)[C@@H]1CC[C@H]2C1.Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120245161A1,COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)OC(C)(C)C)ccc3OCC(=O)N(C)C)CC2)c2cccc(OC(F)(F)F)c21.Cl>>COCCn1cc(C(=O)N2CCC(c3cc(CN)ccc3OCC(=O)N(C)C)CC2)c2cccc(OC(F)(F)F)c21.Cl,,C1COCCO1,,,,val
US20100009969A1,CC1CCCN1CCCOc1ccc(-c2nc3c(s2)CCNCC3)cc1.O=C(Cl)N1CCOCC1>>CC1CCCN1CCCOc1ccc(-c2nc3c(s2)CCN(C(=O)N2CCOCC2)CC3)cc1,,ClCCl,,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US06255323B1,OC(c1ccccc1)c1ccccc1.OCC1CCNCC1>>c1ccc(C(OCC2CCNCC2)c2ccccc2)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20160143870A1,CC(C)CN(CC(C)C)c1ccc(Br)cc1N.CC1(C)COB(B2OCC(C)(C)CO2)OC1>>CC(C)CN(CC(C)C)c1ccc(B2OCC(C)(C)CO2)cc1N,,CS(C)=O,,CC(=O)[O-].[K+],,val
US20110294793A1,N#Cc1ccc(S(=O)(=O)Cl)cc1.NCc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cc(Cl)cc(Cl)c2O)c1>>N#Cc1ccc(S(=O)(=O)NCc2cccc(CN(Cc3ccc(-c4ccccc4)cc3)S(=O)(=O)c3cc(Cl)cc(Cl)c3O)c2)cc1,,ClCCl,,CCN(CC)CC,,val
US20110092497A1,CC1(C)OB(c2ccc(C(N)=O)cc2)OC1(C)C.CN1CCN(c2ccc(Nc3ncc(Br)n4ccnc34)cc2F)CC1>>CN1CCN(c2ccc(Nc3ncc(-c4ccc(C(N)=O)cc4)n4ccnc34)cc2F)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US05714487,CS(=O)(=O)O[C@@H]1C[C@H]2CN(c3ncc(F)cn3)CCN2C1.OCc1ccc(F)cc1>>Fc1ccc(CO[C@H]2C[C@H]3CN(c4ncc(F)cn4)CCN3C2)cc1,,CN(C)C=O,O,[H-].[Na+],,val
US20120245172A1,Clc1cc(C2CO2)ccc1Br.NCCO>>OCCNCC(O)c1ccc(Br)c(Cl)c1,,C1CCOC1,,CCOC(C)=O,,val
US20160068532A1,Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc(N)c(CN)cc23)ccn1.Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc(N)c(CNCc4ccccc4)cc23)ccn1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc4c(cc23)CN(Cc2ccccc2)C(=O)N4)ccn1.Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc4c(cc23)CNC(=O)N4)ccn1,,C1COCCO1,ClCCl,,,val
US20140336185A1,COc1ccc(CC(=O)Nc2ccc(C(=O)N(CC(=O)OC(C)(C)C)Cc3ccc(-c4nc(-c5ccc(-c6ccc(C)cc6)cc5)no4)cc3)cc2)c(C(F)(F)F)c1>>COc1ccc(CC(=O)Nc2ccc(C(=O)N(CC(=O)O)Cc3ccc(-c4nc(-c5ccc(-c6ccc(C)cc6)cc5)no4)cc3)cc2)c(C(F)(F)F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020193411A1,N#Cc1cc(N)n(-c2c(Cl)cc(-c3ccc(C(F)(F)F)cc3)cc2Cl)n1.O=C1CCC(=O)N1Br>>N#Cc1nn(-c2c(Cl)cc(-c3ccc(C(F)(F)F)cc3)cc2Cl)c(N)c1Br,,CC#N,,,,val
US20120165305A1,COC(=O)c1cccc(-c2cnnc(N)c2)c1.O=CCCl>>COC(=O)c1cccc(-c2cnn3ccnc3c2)c1,,CC(C)O,O,,,val
US20150238601A1,Clc1ccnc(Cl)n1.Nc1cn[nH]c1>>Clc1nccc(Nc2cn[nH]c2)n1,,CC(C)O,,,,val
US20030008884A1,Cc1cc(Oc2cccc(C(C)(C)C)c2)c(C)cc1N.S=C(Cl)Cl>>Cc1cc(Oc2cccc(C(C)(C)C)c2)c(C)cc1N=C=S,,Cc1ccccc1,O,O=C([O-])O.[Na+],,val
US20070197537A1,CCOC(=O)C(=O)Nc1ccc(Oc2ccnc3ccsc23)c(F)c1.NCCN1CCOCC1>>O=C(NCCN1CCOCC1)C(=O)Nc1ccc(Oc2ccnc3ccsc23)c(F)c1,,CCOCC,,,,val
US05075311,CCCCn1c2c(c(=O)[nH]c1=O)C(c1ccc(F)cc1)C(C(=O)OCC)=C(C(C)C)N2>>CCCCn1c(=O)[nH]c(=O)c2c(-c3ccc(F)cc3)c(C(=O)OCC)c(C(C)C)nc21,,ClCCl,,,,val
US20050065191A1,CCNC1=CC(=O)CC1.COC(=O)Cl>>CCN(C(=O)OC)C1=CC(=O)CC1,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20040209905A1,CCCNCCC.COc1cc2ncnc(Oc3ccc(N)c(Cl)c3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCN(CCC)C(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl,,CCN(CC)CC,ClC(Cl)Cl,CO,,val
US20040087577A1,Nn1c(=O)c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc21.O=Cc1cccnc1>>O=c1c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc2n1N=Cc1cccnc1,,CC(=O)N(C)C,,,,val
US06489351B1,CCc1nc2c(s1)CCc1c(C(=O)O)sc(SC)c1-2.CN(C)C=O>>CCc1nc2c(s1)CCc1c(C(N)=O)sc(SC)c1-2,,C1CCOC1,,O=C(Cl)C(=O)Cl,,val
US20020099013A1,Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1.O=C1CCC(=O)N1O>>Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1.O=C1CCC(=O)N1,,C1COCCO1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20110287937A1,O=C(Cl)C(=O)Cl.O=C(O)c1cc2cccnc2n(Cc2ccccc2)c1=O>>O=C(Cl)c1cc2cccnc2n(Cc2ccccc2)c1=O,,ClCCl,,CN(C)C=O,,val
US20120058985A1,CC(C)(F)C(=O)O.Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1>>CC(C)(F)C(=O)Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04983612,COC=O.O=C(Nc1ccccc1)c1ccccn1>>O=C1c2ncccc2C(O)N1c1ccccc1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20020156081A1,COc1cc(-c2nn(-c3ccc(C=O)cc3)c3ncnc(N)c23)ccc1NC(=O)c1ccc(C(F)(F)F)cc1F.OCCN1CCNCC1>>COc1cc(-c2nn(-c3ccc(CN4CCN(CCO)CC4)cc3)c3ncnc(N)c23)ccc1NC(=O)c1ccc(C(F)(F)F)cc1F,,CC(Cl)Cl,,[Na+].[OH-],,val
US20080188528A1,CC(C)(C)OC(=O)NCCC[C@H](NC(=O)c1cccn(Cc2cccc(I)c2)c1=O)C(=O)O.O=C(O)C(F)(F)F>>NCCC[C@H](NC(=O)c1cccn(Cc2cccc(I)c2)c1=O)C(=O)O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20050107307A1,CC(C)C[C@@H](B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1)N([Si](C)(C)C)[Si](C)(C)C.Cl>>CC(C)C[C@H](N)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1.Cl,,C1COCCO1,CCOCC,,,val
US20140031344A1,CCCCCC.CN(C)CCN(C)C.NC(=O)c1cccnc1.[Li]CCCC>>O=C1Cc2ccncc2Nc2ncccc21,,C1CCOC1,,CC(C)NC(C)C,,val
US20110028478A1,O=C(OO)c1cccc(Cl)c1.O=S(C1=NOCC1)c1ccccc1>>O=S(=O)(C1=NOCC1)c1ccccc1,,ClCCl,,O,,val
US20140275019A1,CC(C)(C)OC(=O)N1CCC2(CC1)Cc1cc(/C=C/C(=O)N3CC=C(Cc4nccs4)CC3)cnc1NC2=O.O=C(O)C(F)(F)F>>O=C(/C=C/c1cnc2c(c1)CC1(CCNCC1)C(=O)N2)N1CC=C(Cc2nccs2)CC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20030149001A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(N4CCOCC4)cn3)ncc12.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>C=C(OCC)c1c(C)c2cnc(Nc3ccc(N4CCCCC4)cn3)nc2n(C2CCCC2)c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,Cc1ccccc1,,val
US20030232832A1,O=S(Cl)Cl.O=c1c2c(Cl)ccn2nc(C(O)C2CC2)n1Cc1ccccc1>>O=c1c2c(Cl)ccn2nc(C(Cl)C2CC2)n1Cc1ccccc1,,ClCCl,,c1ccncc1,,val
US20070191627A1,CCOP(=O)(Cc1ccc(OC)cc1)OCC.COc1cc(C=O)cc(OC)c1>>COc1cccc(C=Cc2cc(OC)cc(OC)c2)c1,,CN(C)C=O,,C[O-].[Na+],,val
US20090137588A1,Nc1cccc(Nc2cc(Cl)ncn2)n1.Oc1ccc2c(c1)OCCO2>>Nc1cccc(Nc2cc(Oc3ccc4c(c3)OCCO4)ncn2)n1,[Cu]I,CN1CCCC1=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150073011A1,CC(C)(C)OC(=O)N1[C@@H](C(O)C2CC2)COC1(C)C>>CC(C)(C)OC(=O)N1[C@@H](C(=O)C2CC2)COC1(C)C,,CCOC(C)=O,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090137613A1,CC(C)[C@H](N)C(=O)OCCOCn1cnc2c(=O)nc(N)[nH]c21.O=C(O)/C=C/C(=O)O>>CC(C)[C@H](N)C(=O)OCCOCn1cnc2c(=O)nc(N)[nH]c21.O=C([O-])/C=C/C(=O)[O-],,CCO,,,,val
US20050043388A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NNC(=O)c1ccc(O)cc1>>CC(C)(C)OC(=O)NNC(=O)c1ccc(O)cc1,,C1CCOC1,,CCOCC,,val
US20050096353A1,CCOC(=O)Cn1ccc2ccc(OCc3ccc(-c4ccc(C(F)(F)F)cc4)nc3C)cc21>>CCOC(=O)CN1CCc2ccc(OCc3ccc(-c4ccc(C(F)(F)F)cc4)nc3C)cc21,,CC(=O)O,,[BH3-]C#N.[Na+],,val
US20030069297A1,Cc1[nH]c(C=O)c(C)c1C(=O)NCCn1ccnn1.O=C1Cc2c(cccc2-c2ccc(Br)cc2)N1>>Cc1[nH]c(C=C2C(=O)Nc3cccc(-c4ccc(Br)cc4)c32)c(C)c1C(=O)NCCn1ccnn1,C1CCNCC1,CCO,,,,val
US20160046581A1,O=C(CNC(=O)C(Cc1ccc(F)cc1)n1ccc(-c2cc(Cl)ccc2[N+](=O)[O-])cc1=O)c1ccc(F)cc1>>O=c1cc(-c2cc(Cl)ccc2[N+](=O)[O-])ccn1C(Cc1ccc(F)cc1)c1ncc(-c2ccc(F)cc2)o1,,C1CCOC1,,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US20030187020A1,CC(C)(C)OC(=O)N(Cc1cccc(C2CCN(C(=O)c3cccc(C#Cc4ccccc4)c3)CC2)c1)C(=O)OC(C)(C)C.Cl>>Cl.NCc1cccc(C2CCN(C(=O)c3cccc(C#Cc4ccccc4)c3)CC2)c1,,CO,,,,val
US04801705,CC(=O)Oc1ccc(C(=O)Cl)cc1OC(C)=O.NC(=O)N1CCN(N)C1=O>>CC(=O)Oc1ccc(C(=O)N2CCN(C(N)=O)C2=O)cc1OC(C)=O,,ClCCl,,CCN(CC)CC,Cl,val
US20130157996A1,COC(=O)c1c[nH]c(=O)c(F)c1>>O=C(O)c1c[nH]c(=O)c(F)c1,,CO,O,[Li+].[OH-],,val
US20010023257A1,O=C1NC(=O)c2ccccc21.OC1CC2CC1C1CCCC21>>O=C1c2ccccc2C(=O)N1C1CC2CC1C1CCCC21,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150210688A1,COC(=O)c1ccc(C)c(-c2cnc(C#N)[nH]2)c1.O=C1CCC(=O)N1Cl>>COC(=O)c1ccc(C)c(-c2[nH]c(C#N)nc2Cl)c1,,ClC(Cl)Cl,,CN(C)C=O,,val
US05223525,FC(F)(F)SCl.Nc1cncn1-c1c(Cl)cc(C(F)(F)F)cc1Cl>>Nc1c(SC(F)(F)F)ncn1-c1c(Cl)cc(C(F)(F)F)cc1Cl,,ClCCl,,O,,val
US20070072813A1,CCOC(=O)C(Cc1ccc(OC)c(F)c1F)C(C)=O.NN>>COc1ccc(Cc2c(O)n[nH]c2C)c(F)c1F,,CCO,,O,,val
US20110224129A1,Brc1ccc(Br)s1.Cc1ccc(B(O)OC(=O)O)cc1>>COC(=O)c1ccc(-c2ccc(Br)s2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,CCO,O=C([O-])[O-].[K+].[K+],val
US20090111840A1,CC(C)(C)OC(=O)N1CCCC2(CCN(Cc3ccccc3)C2)C1COS(C)(=O)=O.[N-]=[N+]=[N-]>>CC(C)(C)OC(=O)N1CCCC2(CCN(Cc3ccccc3)C2)C1N=[N+]=[N-],,CN(C)C=O,,O,,val
US20090062267A1,COC(=O)[C@H](Cc1ccc(CCCc2ccc3cccnc3n2)nc1)NC(=O)OC(C)(C)C>>COC(=O)[C@H](Cc1ccc(CCCc2ccc3c(n2)NCCC3)nc1)NC(=O)OC(C)(C)C,[Pd],CCO,,,,val
US05166347,COC(=NC#N)c1ccccn1.Nc1ccccc1>>N#CNC(=Nc1ccccc1)c1ccccn1,,CO,,,,val
US20100056531A1,CCOC(=O)CCl.Nc1c[nH]c2cccnc12>>CCOC(=O)CNc1c[nH]c2cccnc12,,CO,,,,val
US20070142411A1,CS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)ccn2)cc1.O=C(OO)c1cccc(Cl)c1>>CS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)cc[n+]2[O-])cc1,,ClCCl,,,,val
US04983597,CC[C@@H]1C(=O)N(S(=O)(=O)c2ccccc2C)[C@@H]1CO.COc1ccc(CC(=O)O)cc1>>CC[C@@H]1C(=O)N(S(=O)(=O)c2ccccc2C)[C@@H]1COC(=O)Cc1ccc(OC)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20120108574A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3c(Cl)nc4n3-c3cccnc3Nc3ccccc3-4)cc2)CCC1.Cl.ClCCl>>Cl.Cl.Cl.NC1(c2ccc(-c3c(Cl)nc4n3-c3cccnc3Nc3ccccc3-4)cc2)CCC1,,ClCCl,,C1COCCO1,,val
US06166006,Nc1ccccn1.O=Cc1ccc([N+](=O)[O-])cc1>>O=[N+]([O-])c1ccc(CNc2ccccn2)cc1,,ClCCCl,,CC(=O)O,,val
US06034275,O=C(c1ccc(Br)cc1)c1ccc(OCC=CCN(C(=O)C(F)(F)F)C2CC2)cc1>>O=C(c1ccc(Br)cc1)c1ccc(OCC=CCNC2CC2)cc1,,C1CCOC1,CO,[K+].[OH-],,val
US05177069,COC(=O)CCC(CS(=O)(=O)c1ccc2ccccc2c1)C(=O)N(CCC1CCCCC1)CCC1CCCCC1>>O=C(O)CCC(CS(=O)(=O)c1ccc2ccccc2c1)C(=O)N(CCC1CCCCC1)CCC1CCCCC1,,CCO,,[Na+].[OH-],,val
US20120142735A1,CCOC(=O)Nc1ccc(F)c(F)c1.II>>CCOC(=O)Nc1ccc(F)c(F)c1I,,C1CCOC1,,[Li]C(C)CC,,val
US05290908,C#CCN.CN(C)C=O.O=C1OC(=O)c2ccc3c4c(ccc1c24)C(=O)OC3=O>>C#CCN=C(O)c1ccc(C(O)=NCC#C)c2c(C(=O)O)ccc(C(=O)O)c12,,CN(C)C=O,,,,val
US20020147338A1,CCc1cc(N)n[nH]1.CSC(C)=NC(=O)c1ccc(Cl)cc1Cl>>CCc1cc2nc(C)nc(-c3ccc(Cl)cc3Cl)n2n1,,C1COCCO1,,,,val
US20090306089A1,C=Cc1ncc(CO[Si](C)(C)C(C)(C)C)cc1Cl>>C=Cc1ncc(CO)cc1Cl,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140349990A1,CCOC(=O)c1nn(Cc2ccc(OC)cc2)cc1C(O)c1ccc(Cl)cc1.Cn1cc(N)cc(Cl)c1=O>>CCOC(=O)c1nn(Cc2ccc(OC)cc2)cc1C(Nc1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1,,CO,ClCCl,,,val
US20140088124A1,COC(=O)C[C@H]1CC[C@@H](OC2CCN(C(=O)OCc3ccccc3)CC2)CC1>>COC(=O)C[C@@H]1CC[C@H](OC2CCNCC2)CC1,[Pd],CO,,,,val
US20050038071A1,CCCCC[Mg]Br.Clc1ccncc1.O=C(Cl)Oc1ccccc1>>CCCCCC1C=C(Cl)C=CN1C(=O)Oc1ccccc1,,C1CCOC1,,Cl,,val
US20150148534A1,O=C1CN[C@@H](c2ccccc2)CO1>>O=C1CN[C@@H](c2ccccc2)CO1,,CCOC(C)=O,,Cl,O=C([O-])O.[Na+],val
US04808597,Cc1ccc2c(c1)C(C)(C)CCO2.O=C1CCC(=O)N1Br>>CC1(C)CCOc2ccc(CBr)cc21,,ClC(Cl)(Cl)Cl,,,,val
US04675276,CCOC(=O)c1ccc(NN)cc1.CN=C=S>>CCOC(=O)c1ccc(NNC(=S)NC)cc1,,c1ccccc1,,,,val
US20160096835A1,N.O=S(=O)(c1ccc(Cl)nc1)N1CCCCC1>>Nc1ccc(S(=O)(=O)N2CCCCC2)cn1,,O,,,,val
US20020040146A1,CC(C)(C)OC(=O)N1C[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CO.Fc1cc(F)c(CBr)cc1F>>CC(C)(C)OC(=O)N1C[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1COCc1cc(F)c(F)cc1F,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20140163015A1,Fc1ccc(Br)cc1[C@]12CO[C@@H](C3CC3)C[C@H]1CON2>>N[C@@]1(c2cc(Br)ccc2F)CO[C@@H](C2CC2)C[C@H]1CO,[Zn],CC(=O)O,,,,val
US20120202785A1,Cc1cccc(Nc2ncccc2NC(=O)[C@H](C)NC(=O)OC(C)(C)C)c1>>Cc1cccc(-n2c([C@H](C)NC(=O)OC(C)(C)C)nc3cccnc32)c1,,CC(=O)O,,,,val
US20110251188A1,N#CC1=C2C(=NC1=O)c1cccc3cccc2c13.Nc1ccc(S)cc1>>N#CC1=C2C(=NC1=O)c1c(Sc3ccc(N)cc3)ccc3cccc2c13,,CC#N,,,,val
US05665718,CCOC(=O)c1ncn2c1CN(C)C(=O)c1c-2ccc(F)c1Cl.NN>>CN1Cc2c(C(=O)NN)ncn2-c2ccc(F)c(Cl)c2C1=O,,CCO,,O,,val
US20040180940A1,CCOC(=O)CC(=O)Nc1cc(Br)c(Oc2cc(CC)c(O)c(C(C)C)c2)c(Br)c1C>>CCc1cc(Oc2c(Br)cc(NC(=O)CC(=O)O)c(C)c2Br)cc(C(C)C)c1O,,C1CCOC1,,Cl,[Li+].[OH-],val
US20070247585A1,CC=CC1CCC2c3ccc(OCC)c(F)c3OC2C1>>CCCC1CCC2c3ccc(OCC)c(F)c3OC2C1,[Pd],C1CCOC1,,[H][H],,val
US20120101136A1,CCOC(=O)CCCCBr.CCc1cc(O)ccc1-c1noc(-c2ccc(OC(C)C)c(Cl)c2)n1>>CCOC(=O)CCCCOc1ccc(-c2noc(-c3ccc(OC(C)C)c(Cl)c3)n2)c(CC)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20120115846A1,COc1ccc(Cn2c(=O)c3cc(OCc4ccccc4)ccc3n(C3CCS(=O)(=O)CC3)c2=O)cc1OC>>COc1ccc(Cn2c(=O)c3cc(O)ccc3n(C3CCS(=O)(=O)CC3)c2=O)cc1OC,,O=CO,,,,val
US20110319394A1,Cn1c(Oc2ccc(Nc3ncncc3N)cc2)nc2ccccc21.O=C(n1ccnc1)n1ccnc1>>Cn1c(Oc2ccc(-n3c(=O)[nH]c4cncnc43)cc2)nc2ccccc21,,C1CCOC1,,,,val
US20130274255A1,CC1(C)OB(c2cccc(N)c2)OC1(C)C.COc1ccc(-c2nn(COCC[Si](C)(C)C)c3c2Cc2sc(Br)cc2-3)cc1>>COc1ccc(-c2nn(COCC[Si](C)(C)C)c3c2Cc2sc(-c4cccc(N)c4)cc2-3)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20160207905A1,CC(C)(C)OC(=O)N1CCCC(N)C1.Clc1ncc(Cl)c(Cl)n1>>CC(C)(C)OC(=O)N1CCCC(Nc2nc(Cl)ncc2Cl)C1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20070021454A1,C=CCI.COC(=O)c1cccc(O)c1>>C=CCOc1cccc(C(=O)OC)c1,,CN(C)C=O,,[H-].[Na+],,val
US20150210682A1,Cc1ccc(C(=O)[O-])cc1OCc1ccccc1>>Cc1ccc(CO)cc1OCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20140171408A1,Fc1c(N=C(Cl)c2c(Cl)cccc2Cl)ccnc1Cl.NC(N)=S>>Clc1cccc(Cl)c1-c1nc2ccnc(Cl)c2s1,,CC(C)O,,CCN(CC)CC,c1ccncc1,val
US20090042811A1,CCCCCCCCCCCCCCCCOC[C@H](O)CO.C[Si](C)(C)N=[N+]=[N-]>>CCCCCCCCCCCCCCCCOC[C@H](CO)N=[N+]=[N-],,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130324506A1,CC(C)(C)C(=O)Cl.CN1CCC(OC2c3ccccc3CCn3cc(-c4ccc(N)cc4)nc32)CC1>>CN1CCC(OC2c3ccccc3CCn3cc(-c4ccc(NC(=O)C(C)(C)C)cc4)nc32)CC1,,ClCCl,,CCN(CC)CC,,val
US20090088425A1,Cc1cnc(C(O)(C(C)c2ccc(OCCNC(=O)OC(C)(C)C)cc2Cl)C(F)(F)F)cn1>>Cc1cnc(C(O)(C(C)c2ccc(OCCN)cc2Cl)C(F)(F)F)cn1,,ClCCl,O,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20140004243A1,NCCc1ccccc1O.S=C(n1ccnc1)n1ccnc1>>Oc1ccccc1CCN=C=S,,CN(C)C=O,,CCN(CC)CC,,val
US20040181067A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(Nc1ncc(Cl)s1)C(CC1CCOCC1)c1ccc(S(=O)(=O)Cl)cc1>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(C(CC3CCOCC3)C(=O)Nc3ncc(Cl)s3)cc2)CC1,,CC(=O)N(C)C,,CCN(CC)CC,,val
US04000153,Cc1nnc(CBr)n1-c1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1Cl.N>>Cc1nnc2n1-c1ccc([N+](=O)[O-])cc1C(c1ccccc1Cl)=NC2,,CO,,,,val
US20120142681A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.CC(c1ccc2c(cnn2C)c1)c1cnc2ccc(Cl)nn12>>C=C(OCC)c1ccc2ncc(C(C)c3ccc4c(cnn4C)c3)n2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20080233127A1,Clc1nc(N2CCOCC2)c2ncn(C3CCN(Cc4ccccc4)CC3)c2n1.NC1(B(O)O)N=CC=CN1>>Nc1ncc(-c2nc(N3CCOCC3)c3ncn(C4CCN(Cc5ccccc5)CC4)c3n2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])O.[Na+],,val
US20150299120A1,COCCl.OC1CCCC1O>>COCOC1CCCC1O,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US20050009829A1,COC(=O)c1ccc(NCc2cc(-c3ccc(Cl)s3)on2)c([N+](=O)[O-])c1>>COC(=O)c1ccc(NCc2cc(-c3ccc(Cl)s3)on2)c(N)c1,,CO,ClCCl,[BH4-].[Na+],,val
US20080132556A1,CCOC(O)C(=O)c1ccc(OCc2ccccc2)c(C(=O)OC)c1.CCc1nc(-c2ccc(OC)cc2)nn1CCC(C)(C)N>>CCc1nc(-c2ccc(OC)cc2)nn1CCC(C)(C)NCC(O)c1ccc(O)c(CO)c1,[Ni],CCO,,,,val
US20100087471A1,CN1C2CCC1CC(=O)C2.NNc1ccccc1>>CN1C2CCC1c1c([nH]c3ccccc13)C2,,CCO,,Cl,,val
US20070135477A1,Nc1c[nH]nc1-c1nc2ccccc2[nH]1.O=C(O)c1ccccc1>>O=C(Nc1c[nH]nc1-c1nc2ccccc2[nH]1)c1ccccc1,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US06166080,CC(NNC=NN)C(=O)O>>CC(NNC=NN)C(=O)O,[Pd],O,,Cl,[H][H],val
US20110046133A1,CC(=O)OC(C)=O.Cc1cc(N)cc(C)c1Br>>CC(=O)Nc1cc(C)c(Br)c(C)c1,,ClCCl,,,,val
US20090111800A1,COc1cc(Cl)c(CC2CCN(C3CCc4n[nH]cc4C3)C2=O)c(Cl)c1>>O=C1C(Cc2c(Cl)cc(O)cc2Cl)CCN1C1CCc2n[nH]cc2C1,,ClCCl,,BrB(Br)Br,CO,val
US20030186967A1,CC1(C)CC(=O)C(=CCNC[C@H](NC(=O)OCc2cccc3c2Cc2ccccc2-3)C(=O)O)C(=O)C1>>CC1(C)CC(=O)C(=CCNCC(N)C(=O)O)C(=O)C1,,CN(C)C=O,,C1CCNCC1,,val
US20140114068A1,CC(C)c1ccc2c(c1)OC1(N)c3ccccc3C(=O)C21O.O=C(O)c1cnnc2ccccc12>>CC(C)c1ccc2c(c1)OC1(O)c3ccccc3C(=O)C21NC(=O)c1cnnc2ccccc12,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4nc(C)cc(C)n4)cc2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4nc(C)cc(C)n4)cc2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US05639780,COc1ccc2c(c1)c(CC(C)CC(=O)N1C(=O)OC[C@H]1C(C)C)c(C)n2Cc1ccc(Br)cc1.OO>>COc1ccc2c(c1)c(CC(C)CC(=O)O)c(C)n2Cc1ccc(Br)cc1,,C1CCOC1,,[Li+].[OH-],,val
US04804750,CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]([C@H](O)[C@H](C=O)NC(C)=O)[C@H](O)CO.CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@H]([C@H](O)CO)[C@H](O)[C@H](C=O)NC(C)=O)[C@H](NC(C)=O)[C@H]1O.CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O>>CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](O[C@H]2[C@H](O)[C@@H](NC(C)=O)[C@H](O[C@H]3[C@H](O)[C@@H](NC(C)=O)[C@H](O[C@@H]4[C@@H](CO)O[C@@H](O[C@H]([C@H](O)CO)[C@H](O)[C@H](C=O)NC(C)=O)[C@H](NC(C)=O)[C@H]4O)O[C@@H]3CO)O[C@@H]2CO)O[C@@H]1CO,,O,,,,val
US05514773,COc1ccccc1C[C@@H]1COC(C)(C)O1>>COc1ccccc1C[C@@H](O)CO,,CCO,,,,val
US20100158818A1,CC(C)(N)CCN1CCC(F)(F)CC1.O=C(OCc1ccccc1)ON1C(=O)CCC1=O>>CC(C)(CCN1CCC(F)(F)CC1)NC(=O)OCc1ccccc1,,C1CCOC1,,,,val
US07037911B2,C[C@@]1(NC(=O)OCc2ccccc2)C[C@@H](C(=O)NCc2ccc(C(=N)NC(=O)OCc3ccccc3)cc2)n2c1c(Cl)nc(NCc1cccc(C(F)(F)F)c1)c2=O>>C[C@@]1(N)C[C@@H](C(=O)NCc2ccc(C(=N)N)cc2)n2c1c(Cl)nc(NCc1cccc(C(F)(F)F)c1)c2=O,[Pd],CO,,[H][H],,val
US20120165318A1,COC(=O)C(N)c1ccccc1.COC(=O)c1ccc(F)c([N+](=O)[O-])c1>>COC(=O)c1ccc(NC(C(=O)OC)c2ccccc2)c([N+](=O)[O-])c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20070232583A1,CC(C)(C)NS(=O)(=O)c1cccc(-c2cc(-c3nc(-c4ccc(C(F)(F)F)cc4F)cc(C(F)(F)F)n3)ccn2)c1>>NS(=O)(=O)c1cccc(-c2cc(-c3nc(-c4ccc(C(F)(F)F)cc4F)cc(C(F)(F)F)n3)ccn2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130018030A1,CC(C)(C)OC(=O)N1CCC(c2cc3cc(-c4ccc(S(C)(=O)=O)cc4)ncc3o2)CC1>>CC(C)(C)OC(=O)N1CCC(C2Cc3cc(-c4ccc(S(C)(=O)=O)cc4)ncc3O2)CC1,[Pd],CO,,CC(=O)O,,val
US06048861,CC(=O)CCCNC(=O)OC(C)(C)C.Nc1ncccc1C=O>>CC(C)(C)OC(=O)NCCCc1ccc2cccnc2n1,,CCO,,[K+].[OH-],,val
US20060281772A1,CC(C)(C)OC(=O)N1CCC(c2ncnc3cc(F)ccc23)CC1.O=C(Nc1ccc(N2CCCC2)cc1)Oc1ccc([N+](=O)[O-])cc1.OCC1CCOCC1>>O=C(Nc1ccc(N2CCCC2)cc1)N1CCC(c2ncnc3cc(OCC4CCOCC4)ccc23)CC1,,CS(C)=O,O,Cl,CC(C)(C)[O-].[K+],val
US20140275133A1,CCOC(=O)C(O)(Cc1ccccc1)C(=O)O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.NC(=O)CCC(=O)NO>>CCOC(=O)C(O)(Cc1ccccc1)C(=O)NN,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20100113462A1,BrC1CCC1.COC(=O)c1cc(Cl)cc(C)c1O>>COC(=O)c1cc(Cl)cc(C)c1OC1CCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120071489A1,CCOC(=O)CC(=O)N1CCN(c2ccc(Br)cc2C(C)(C)C)CC1>>CC(C)(C)c1cc(Br)ccc1N1CCN(C(=O)CC(=O)O)CC1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20020183364A1,Cc1c(C=O)[nH]c2ccccc12.O=C1Cc2cc(C(=O)O)ccc2N1>>Cc1c(C=C2C(=O)Nc3ccc(C(=O)O)cc32)[nH]c2ccccc12,,CCO,,C1CCNCC1,,val
US20130137661A1,CCOC(=O)CCCBr.Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F>>CCOC(=O)CCCN[C@@H](Cn1c(=O)c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(C)n(Cc2c(F)cccc2C(F)(F)F)c1=O)c1ccccc1,,CC#N,ClCCl,CCN(C(C)C)C(C)C,,val
US20060276493A1,Cc1cc(O[Si](C)(C)C)ccc1C(=O)[O-]>>Cc1cc(O)ccc1C(=O)O,,CO,O,Cl,[Li+].[OH-],val
US20100273775A1,Fc1ccc(C#Cc2ccnc(Cl)n2)c(F)c1.Oc1on[n+]2c1CSC2>>Fc1ccc(-c2nn3c(c2-c2ccnc(Cl)n2)CSC3)c(F)c1,,Cc1cc(C)cc(C)c1,,,,val
US04275209,Cc1ccc2sc3cc(F)ccc3c(=O)c2c1.Cc1cccc2sc3ccc(C(F)(F)F)cc3c(=O)c12>>Cc1ccc2c(=O)c3cc(C(F)(F)F)ccc3sc2c1,,CC(C)=O,,O=S(=O)(O)O,,val
US20040116435A1,BrB(Br)Br.COc1ccc(NC(C)=O)c(OC[C@@H](O)CN2CCC(n3c(=O)[nH]c4cc(F)ccc43)CC2)c1>>COc1cc(OC[C@@H](O)CN2CCC(n3c(=O)[nH]c4cc(F)ccc43)CC2)c(NC(C)=O)cc1Br,,ClCCl,ClCCl,CN(C)C=O,,val
US20100121052A1,BrBr.Nc1c(F)cccc1C(=O)O>>Nc1c(F)cc(Br)cc1C(=O)O,,ClC(Cl)Cl,,Br,,val
US05919748,CC(C)O.CCCCCCCCCCCCCCCCCCOCC1CO1.Cl.N=C(N)NCCC[C@H](N)C(=O)O>>CCCCCCCCCCCCCCCC(OCCCN[C@@H](CCCNC(=N)N)C(=O)O)C(C)O.Cl,,O,,,,val
US20040198975A1,CC(O)c1ccccc1.FC(F)(F)c1ccccc1>>CC(F)c1ccccc1,,ClCCl,,,,val
US06391520B1,O=C(O)C12CC3(O)CC(O)(CC(O)(C3)C1)C2>>OCC12CC3(O)CC(O)(CC(O)(C3)C1)C2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080207654A1,CCCCc1nc(C)n(Cc2csc3ccc(Cl)cc23)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCCc1nc(C)n(Cc2csc3ccc(Cl)cc23)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US04904674,CC1(C)OCC(CO)O1.O=C(Cl)c1ccc(C=Cc2csc3ccccc23)s1>>O=C(O)c1ccc(C=Cc2csc3ccccc23)s1,,c1ccncc1,,,,val
US20140309272A1,CC(C)(C)OC(=O)NCC(N)c1c[nH]c2ccc(Cl)cc12.O=C(O)c1c[nH]c2ccc(Cl)cc12>>CC(C)(C)OC(=O)NCC(NC(=O)c1c[nH]c2ccc(Cl)cc12)c1c[nH]c2ccc(Cl)cc12,,ClCCl,,CCN=C=NCCCN(C)C,,val
US20020195585A1,CCC/C=C/CCO.Oc1ccc(-c2ncc(OCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cn2)cc1>>CCC/C=C/CCOc1ccc(-c2ncc(OCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cn2)cc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05912353,CCc1nnc(NC(=O)C(F)(F)F)s1.N#Cc1ccccc1-c1ccc(CBr)cc1>>CCc1nn(Cc2ccc(-c3ccccc3C#N)cc2)c(=NC(=O)C(F)(F)F)s1,,CN(C)C=O,,[H][H],[H-].[Na+],val
US06596738B1,CC(C)(C)[Si](C)(C)OC[C@@H](CCn1ccc2ccc(O)cc21)n1cnc(C(N)=O)c1.CCCCI>>CCCCOc1ccc2ccn(CC[C@H](CO[Si](C)(C)C(C)(C)C)n3cnc(C(N)=O)c3)c2c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060128755A1,CCOC(=O)CCCN(CC)c1cccc(C)c1>>CCN(CCCC(=O)O)c1cccc(C)c1,,C1COCCO1,O,Cl,,val
US20130072679A1,COC(=O)CBr.Cc1ccc(S(=O)(=O)Cc2nc(Br)ccc2[N+](=O)[O-])cc1>>COC(=O)CC(c1nc(Br)ccc1[N+](=O)[O-])S(=O)(=O)c1ccc(C)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110237517A1,CC(C)(C)OC(=O)N1CCC2C1C(c1c[nH]c3cc(F)ccc13)CN2C1CCCC1>>Fc1ccc2c(C3CN(C4CCCC4)C4CCNC34)c[nH]c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150094297A1,COC(=O)c1nc(N2CCOCC2)sc1C(F)(F)F>>OCc1nc(N2CCOCC2)sc1C(F)(F)F,,C1CCOC1,,CO,[BH4-].[Li+],val
US20100035926A1,Cc1ccc(S(=O)(=O)Cl)cc1.Nc1c(C(=O)NCC(O)(CO)C(F)(F)F)cnn1-c1ccc(F)cc1>>Cc1ccc(S(=O)(=O)OCC(O)(CNC(=O)c2cnn(-c3ccc(F)cc3)c2N)C(F)(F)F)cc1,,ClCCl,c1ccncc1,,,val
US05128448,CCOC(=O)CCc1cc2ccccc2s1>>O=C(O)CCc1cc2ccccc2s1,,CO,,O,[K+].[OH-],val
US20040167183A1,Cc1ccc(S(=O)(=O)NCCc2ccc([N+](=O)[O-])cc2)cc1>>Cc1ccc(S(=O)(=O)NCCc2ccc(N)cc2)cc1,[Pd],CCOC(C)=O,CO,,,val
US20160002218A1,CC(C)(C)OC(=O)N1CCCC2(COC2)C1.O=C(O)C(F)(F)F>>C1CNCC2(C1)COC2.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20150065704A1,NC(=O)N1c2ccccc2CC(=O)c2ccccc21>>NC(=O)N1c2ccccc2CC(O)c2ccccc21,,CO,O,Cl,[BH4-].[Na+],val
US20160175284A1,COc1ccc(OC)c(C(=O)Cc2ccc(F)cc2)c1F>>O=C(Cc1ccc(F)cc1)c1c(O)ccc(O)c1F,,ClCCl,O,BrB(Br)Br,CO,val
US05532267,CC(C)(C)OC(=O)C=Cc1ccc(C(=O)NCc2ccc(C(=O)Oc3ccc4cc(C(=N)N)ccc4c3)o2)cc1.Cl>>Cl.N=C(N)c1ccc2cc(OC(=O)c3ccc(CNC(=O)c4ccc(C=CC(=O)O)cc4)o3)ccc2c1,,CC(=O)O,,,,val
US20130053386A1,CCn1[nH]c(=O)cc1-c1cccc(C#N)c1.O=[N+]([O-])c1cc(F)ccc1F>>CCn1nc(Oc2ccc(F)cc2[N+](=O)[O-])cc1-c1cccc(C#N)c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090105474A1,CC(C)(C)OC(=O)c1ccc(Br)cc1Nc1ccc(F)cc1.CC1(C)OB(c2cncc3ccccc23)OC1(C)C>>CC(C)(C)OC(=O)c1ccc(-c2cncc3ccccc23)cc1Nc1ccc(F)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])O.[Na+],val
US04661438,C=CCOS(=O)(=O)C(F)(F)F.Cc1nc2ccccc2[te]1>>C=CC[n+]1c(C)[te]c2ccccc21.O=S(=O)([O-])C(F)(F)F,,ClC(Cl)(Cl)Cl,ClCCl,,,val
US20120187392A1,Brc1ccc(I)cc1.OB(O)c1ccc2c3c(cccc13)-c1c-2c(-c2ccccc2)c2ccccc2c1-c1ccccc1>>Brc1ccc(-c2ccc3c4c(cccc24)-c2c-3c(-c3ccccc3)c3ccccc3c2-c2ccccc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20130045964A1,CNC(=O)C(N)C#N.O=C(O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1>>CNC(=O)C(C#N)NC(=O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05117057,BrCc1ccccc1.CC(C)(C)NNC(=O)c1ccco1>>CC(C)(C)N(Cc1ccccc1)NC(=O)c1ccco1,,CCOCC,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20070281933A1,Cc1nc(S(=O)(=O)Cl)cn1C.NC(=O)c1cc(-c2cn[nH]c2)cc2c(C3CCNCC3)n[nH]c12>>Cc1nc(S(=O)(=O)N2CCC(c3n[nH]c4c(C(N)=O)cc(-c5cn[nH]c5)cc34)CC2)cn1C,CN(C)c1ccncc1,,,CCN(C(C)C)C(C)C,,val
US20050107377A1,C1CCNCC1.Fc1ccc2c(-c3ccc(OC[C@H]4CO4)cc3)noc2c1>>O[C@@H](COc1ccc(-c2noc3cc(F)ccc23)cc1)CN1CCCCC1,,CCO,CN(C)C=O,,,val
US20090247559A1,C#CCO.O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1oc1ccc(Br)cc12>>O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1oc1ccc(CCCO)cc12,[Pd],CC(C)(C)O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160106842A1,C=COCCCCOS(C)(=O)=O.CC(C)(C)[Si](C)(C)OCC(O)CO[Si](C)(C)C(C)(C)C>>C=COCCCCOC(CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US06872515B2,CCCCC(CC)COC(=O)/C(=C\C(=O)[O-])CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F.O=S([O-])O.[Na+]>>CCCCC(CC)COC(=O)C(CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(CC(=O)[O-])S(=O)(=O)O.[Na+],,CCOC(C)=O,,CCO,O,val
US07375227B2,Cc1cc(N=C=O)c2ccccc2n1.NCC(c1ccccc1)N1CCC(O)(Cc2ccccc2)CC1>>Cc1cc(NC(=O)NCC(c2ccccc2)N2CCC(O)(Cc3ccccc3)CC2)c2ccccc2n1,,Cc1ccccc1,ClCCl,,,val
US20120101103A1,CNC.O=Cc1ccc(C(F)(F)F)nc1Cl>>CN(C)c1nc(C(F)(F)F)ccc1C=O,,C1CCOC1,,,,val
US20030027847A1,CC(=O)Cl.NCc1cccc(-c2ccccc2)c1>>CC(=O)NCc1cccc(-c2ccccc2)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US20090291940A1,CNC.Cc1cc2nc(Cl)nc(Cl)c2s1>>Cc1cc2nc(Cl)nc(N(C)C)c2s1,,CCO,,CCN(CC)CC,,val
US20050119492A1,CCOC(=O)C(CC)CN[C@@H](C)C(=O)O.O=C(Cl)OCc1ccccc1>>CCOC(=O)C(CC)CN(C(=O)OCc1ccccc1)[C@@H](C)C(=O)O,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US04267176,CCCCCC.Cc1cccc(N([Si](C)(C)C)[Si](C)(C)C)n1.O=C=O>>CCOC(=O)Cc1cccc(N)n1,,C1CCOC1,,[Li]CCCC,,val
US20030013708A1,COC(=O)c1cc(=O)c2cc(OC)cc(Br)c2[nH]1.C[Si](C)(C)CCOCCl>>COC(=O)c1cc(OCOCC[Si](C)(C)C)c2cc(OC)cc(Br)c2n1,,CN1CCCC1=O,,O,[H-].[Na+],val
US04598077,CN.COC(=N)c1ccc(C=Cc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)cc1.Cl>>CNC(=N)c1ccc(C=Cc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)cc1.Cl,,CCOCC,,CO,ClC(Cl)Cl,val
US20110178132A1,COc1ccc(-c2ccnc(C#N)c2)c(C(F)(F)F)c1.NO>>COc1ccc(-c2ccnc(C(N)=NO)c2)c(C(F)(F)F)c1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20050239780A1,Cc1nc2c(c(C)c1CCC(=O)O)c1ccccc1n2Cc1ccc([C@@H](C(=O)NCc2ccccc2)C2CCOCC2)cc1>>Cc1nc2c(c(C)c1CCCO)c1ccccc1n2Cc1ccc([C@@H](C(=O)NCc2ccccc2)C2CCOCC2)cc1,,C1CCOC1,,O,O=C([O-])[O-].[K+].[K+],val
US20140221344A1,CC(C)(C)[Si](C)(C)O[C@@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ccccc4Cl)nn23)C1>>O[C@@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ccccc4Cl)nn23)C1,,C1CCOC1,CO,Cl,,val
US20130216498A1,C[C@H](Nc1ccnc(-c2cnc3ccc(C#N)cn23)n1)c1ccccc1.OCCO.[OH-]>>C[C@H](Nc1ccnc(-c2cnc3ccc(C(=O)O)cn23)n1)c1ccccc1,,OCCO,,O,,val
US20110059934A1,CC(C)(N)C(=O)N1CCn2c(nc(-c3ccc(F)cc3)c2Nc2ccc(F)c(F)c2)C1>>CC1(C)NC2c3nc(-c4ccc(F)cc4)c(Nc4ccc(F)c(F)c4)n3CCN2C1=O,O=[Mn]=O,,,,,val
US20030171309A1,CON=C1C[C@@H](C(=O)NC[C@@H](O)c2ccccc2)N(C(=O)OC(C)(C)C)C1>>CON=C1CN[C@H](C(=O)NC[C@@H](O)c2ccccc2)C1,,ClCCl,,,,val
US20150005313A1,Clc1ncccc1I.OB(O)C1CC1>>Clc1ncccc1C1CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20070225372A1,CC(C)(C)OC(=O)N1C[C@H](OCc2ccccc2)CC[C@@H]1C=O.O=[N+]([O-])CCc1cc(F)cc(F)c1>>CC(C)(C)OC(=O)N1C[C@H](OCc2ccccc2)CC[C@@H]1C(O)C(Cc1cc(F)cc(F)c1)[N+](=O)[O-],,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20060287291A1,NCCNCc1ccccc1.O=CC(=O)C(F)(F)F>>FC(F)(F)C1CN(Cc2ccccc2)CCN1,,CN(C)C=O,,[Na+].[OH-],,val
US20090233955A1,CC(C)(C)OC(=O)NCCC(=O)Nc1ccc(-c2cnc3[nH]cc(Br)c3c2)cn1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NCCC(=O)Nc1ccc(-c2cnc3c(c2)c(Br)cn3C(=O)OC(C)(C)C)cn1,CN(C)c1ccncc1,C1CCOC1,CCOCC,,,val
US20070299087A1,NCCCN.S=C1NC(c2ccoc2)(c2cccc(Br)c2)C(=S)S1>>S=C1NC(c2ccoc2)(c2cccc(Br)c2)C2=NCCCN12,,CCO,,,,val
US20160213648A1,Cc1nc2ccccc2c(=O)n1-c1cccc(-n2nn[nH]c2=O)c1.N#Cc1ccc(C=O)cc1>>N#Cc1ccc(/C=C/c2nc3ccccc3c(=O)n2-c2cccc(-n3nn[nH]c3=O)c2)cc1,,CC(=O)O,,,,val
US20100113417A1,COC(=O)CC1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1>>O=C(O)CC1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20130190330A1,BrC(Br)(Br)Br.OCc1cn(-c2ccccc2Cl)cn1>>Clc1ccccc1-n1cnc(CBr)c1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20080262042A1,CC(C)O.CCOC(C)=O.CCOC(C)=O.CN(Cc1cn(S(=O)(=O)c2cccc(CO)c2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C>>CNCc1cn(S(=O)(=O)c2cccc(COC(C)=O)c2)c(-c2cccnc2F)c1F.O=C(O)/C=C/C(=O)O,,CC(C)O,,Cl,,val
US20120149737A1,CCO.O=[N+]([O-])c1cc(C(F)(F)F)c(Cl)c(C(F)(F)F)c1>>CCOc1c(C(F)(F)F)cc([N+](=O)[O-])cc1C(F)(F)F,,CS(C)=O,,[K+].[OH-],,val
US06180637B2,CSc1ccc2c(c1)c(O)nn2Cc1ccc(Cl)c(Cl)c1.O.O=[N+]([O-])c1ccc(O)c(CCl)c1>>CSc1ccc2c(c1)c(=O)n(Cc1cc([N+](=O)[O-])ccc1O)n2Cc1ccc(Cl)c(Cl)c1.O,,CS(C)=O,,[H-].[Na+],,val
US20150166543A1,CC/C=C/c1cc(OC)cc(OC)c1>>CCCCc1cc(OC)cc(OC)c1,[Pd],CCO,,,,val
US20040122001A1,CCOC(=O)CC1CCCc2cc(C#N)ccc21>>N#Cc1ccc2c(c1)CCCC2CCO,,C1CCOC1,CCOC(C)=O,[BH4-].[Li+],,val
US20080312226A1,Fc1ccc(-c2csc(N3CCCCC3)n2)cc1>>Fc1ccc(-c2csc(N3CCCCC3)n2)cc1,,O,,Cl,[Na+].[OH-],val
US20050032786A1,CCOCCOc1ccc(C#N)cn1.COC(=O)c1ccccc1S>>CCOCCOc1ccc(-c2nc(=O)c3ccccc3s2)cn1,,Cc1ccccc1,,CCN(CC)CC,,val
US20140275245A1,NC12CC(C(=O)O)(C1)C2.[Li]C>>CC(=O)C12CC(N)(C1)C2,,C1CCOC1,,CCOC(C)=O,[Cl-].[NH4+],val
US20060058308A1,CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4)nc(Cl)n3)cccc2s1.CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1>>CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4)nc(C4=CCN(C(=O)OC(C)(C)C)CC4)n3)cccc2s1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20040072690A1,CCCCCCCNCCOc1ccc(CC(OCC)C(=O)OCC)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCC(F)(F)F>>CCCCCCCN(CCOc1ccc(CC(OCC)C(=O)OCC)cc1)C(=O)OCC(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20110118262A1,CC(C)(C)OC(=O)N1CC=C(c2ccc(C(=O)O)cc2C(F)(F)F)C1>>CC(C)(C)OC(=O)N1CCC(c2ccc(C(=O)O)cc2C(F)(F)F)C1,[Pd],CO,,[H][H],,val
US20110086854A1,CC(C)(C)CC1CNC(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.CC(C)(O)Cn1ccc(N)n1.O=C(Cl)Cl>>CC(C)(C)CC1CN(C(=O)Nc2ccn(CC(C)(C)O)n2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(CC)CC,,val
US20120184542A1,COC(=O)c1ccc(Cl)c(N)c1.COc1nc(C)c2cc(C(=O)O)c(=O)[nH]c2n1>>COC(=O)c1ccc(Cl)c(NC(=O)c2cc3c(C)nc(OC)nc3[nH]c2=O)c1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080287446A1,CC(C)(C)OC(=O)N[C@@H]1CCOC1=O.Sc1ccccn1>>CC(C)(C)OC(=O)N[C@@H](CCSc1ccccn1)C(=O)O,,CO,,[Na],,val
US08399464B2,C=CCOc1cc(OCC=C)c(C(=S)Nc2ccc(CN3CCOCC3)cc2)cc1CC#CC.NN>>C=CCOc1cc(OCC=C)c(C(=NN)Nc2ccc(N3CCOCC3)cc2)cc1CC#CC,,CCO,,O,,val
US04940710,CC(=O)c1ccco1.O=[Se]=O>>O=CC(=O)c1ccco1,,C1COCCO1,,O,,val
US20160122341A1,CCOC(=O)c1cncc(B2OC(C)(C)C(C)(C)O2)c1.Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(Br)n2c1.O=C(O)C(F)(F)F>>CCOC(=O)c1cncc(-c2c(C)nc3c(OCc4c(F)cccc4F)cc(C)cn23)c1.O=C(O)C(F)(F)F,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20120295903A1,CCOC(=O)CNS(=O)(=O)NC(=O)OC(C)(C)C.O=C(NCCO)OCc1ccccc1>>CCOC(=O)CNS(=O)(=O)N(CCNC(=O)OCc1ccccc1)C(=O)OC(C)(C)C,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090082440A1,CC(C)(COS(=O)(=O)CCCCl)[C@@H](OCc1ccccc1)C(=O)O.CO>>COC(=O)[C@H](OCc1ccccc1)C(C)(C)COS(=O)(=O)CCCCl,,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US05298660,C[C@@H](N)c1ccc(Br)cc1.O=Cc1ccc(O)cc1>>CC(N=Cc1ccc(O)cc1)c1ccc(Br)cc1,,CCO,,,,val
US20100273764A1,CC(=O)Nc1ccc(N)cc1F.COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(CN4CCN(S(C)(=O)=O)CC4)cnc3F)n2)cc1>>COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(CN4CCN(S(C)(=O)=O)CC4)cnc3Nc3ccc(NC(C)=O)c(F)c3)n2)cc1,,C1CCOC1,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20160031817A1,Cc1ccc(S(=O)(=O)N2CC=CC(=O)[C@@H]2c2ccccc2)cc1>>Cc1ccc(S(=O)(=O)N2CCCC(=O)[C@@H]2c2ccccc2)cc1,[Pd],CCOC(C)=O,,,,val
US20150018363A1,Cn1c(C2CC2C(C)(C)O)nc2ccc(Br)cc21.O=c1cc(OCc2ccc(Cl)cc2)cc[nH]1>>Cn1c(C2CC2C(C)(C)O)nc2ccc(-n3ccc(OCc4ccc(Cl)cc4)cc3=O)cc21,I[Cu]I,CS(C)=O,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US20130131040A1,Cc1cc(Nc2nc(N[C@H](CC3CC3)C(N)=O)cnc2C#N)sn1.OO>>Cc1cc(Nc2nc(N[C@H](CC3CC3)C(N)=O)cnc2C(N)=O)sn1,,CCO,CS(C)=O,CC(=O)O,[Na+].[OH-],val
US20140011827A1,CN1CC(=O)NC1=O.COc1ccc(CCl)cc1>>COc1ccc(CN2C(=O)CN(C)C2=O)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020107278A1,Cc1csc(NC(=O)Cn2c3c(c4c(Br)cccc42)CCN(C(=O)OC(C)(C)C)CC3)n1>>Cc1csc(NC(=O)Cn2c3c(c4c(Br)cccc42)CCNCC3)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04757080,CC(=O)C(=Cc1cccc([N+](=O)[O-])c1)C(=O)OCCCCCCCCN1C(=O)c2ccccc2C1=O.COC(=O)/C=C(/C)N>>COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCCCCCCN2C(=O)c3ccccc3C2=O)C1c1cccc([N+](=O)[O-])c1,,CC(C)O,,,,val
US20100249099A1,COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCC(N)CC2)n1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCC(NS(=O)(=O)C(F)(F)F)CC2)n1,,ClCCl,,CCN(CC)CC,O,val
US20140005164A1,COc1ccc2c(c1)n(C[C@@H]1CC[C@@H](C(=O)CC(=O)c3ccncc3)CC1)c(=O)n2C.NN>>COc1ccc2c(c1)n(C[C@@H]1CC[C@@H](c3cc(-c4ccncc4)n[nH]3)CC1)c(=O)n2C,,CCO,,O,,val
US20040010141A1,CCOC(=O)C1(C(=O)OCC)CCCN1c1ccc(Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)nc1.NC(N)=O>>O=C1NC(=O)C2(CCCN2c2ccc(Oc3ccc4c(cnn4-c4ccc(F)cc4)c3)nc2)C(=O)N1,,CCO,,[Na],,val
US20110166359A1,CCOC(=N)c1ccccc1.CCOC(=O)[C@@H](N)[C@H](O)c1ccc(S(C)(=O)=O)cc1>>CCOC(=O)[C@H]1N=C(c2ccccc2)O[C@@H]1c1ccc(S(C)(=O)=O)cc1,,O,,CCN(CC)CC,Cl,val
US20080114007A1,CS(=O)(=O)OCCc1cccc([N+](=O)[O-])c1.O=S1(=O)CCNCC1>>Nc1cccc(CCN2CCS(=O)(=O)CC2)c1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110053916A1,NCCN.O=S(=O)(Cl)c1ccc(Br)s1>>NCCNS(=O)(=O)c1ccc(Br)s1,,ClCCl,,O,,val
US20150252038A1,CC(C)(C)OC(=O)c1cc(C2CC2)c(OCC2=CN(C(c3ccccc3)c3ccccc3)C2)cc1F>>O=C(O)c1cc(C2CC2)c(OCC2CN(C(c3ccccc3)c3ccccc3)C2)cc1F,,CS(C)=O,,[K+].[OH-],,val
US20040122002A1,COC(=O)C#Cc1ccccc1.O=C(O)C1CCCN1C(=O)c1ccc(F)cc1>>COC(=O)c1c(-c2ccccc2)c(-c2ccc(F)cc2)n2c1CCC2,,CC(=O)OC(C)=O,,CC(C)OC(C)C,,val
US05387585,CN(C)C=O.ClCc1nc2ccsc2c2nncn12>>O=C1Cn2ncnc2-c2sccc2N1,,C1COCCO1,,[Na+].[OH-],,val
US20040082643A1,Cc1c(C(=O)OCc2ccccc2)cc(Br)cc1[N+](=O)[O-]>>Cc1c(N)cc(Br)cc1C(=O)OCc1ccccc1,[Fe],CCOC(C)=O,,O,[Cl-].[NH4+],val
US20030092677A1,CC(C)(C)OC(=O)Nc1ccc(C2CC2)cc1NC(=O)CC(=O)c1cccc(-n2ccnc2)c1>>O=C1CC(c2cccc(-n3ccnc3)c2)=Nc2ccc(C3CC3)cc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccc(C(=O)OC(C)(C)C)cc3)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccc(C(=O)O)cc3)c2)=C(C)C1=O,,O=CO,,,,val
US20140148574A1,CCC[C@H](N)[C@H](O)C(=O)OC.Cl.NC1CC1>>CCC[C@H](N)[C@H](O)C(=O)[N-]C1CC1.Cl,,C1CCOC1,,,,val
US20130053382A1,CC(C)(C)OC(=O)NCc1cccc(-c2cc3cnn(COCC[Si](C)(C)C)c3cc2NC(=O)c2csc(Br)n2)c1.CCCC[Sn](CCCC)(CCCC)c1cc(-c2ccccc2)nn1C1CCCCO1>>CC(C)(C)OC(=O)NCc1cccc(-c2cc3cnn(COCC[Si](C)(C)C)c3cc2NC(=O)c2csc(-c3cc(-c4ccccc4)nn3C3CCCCO3)n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,,,val
US05760050,BrCCc1ccccc1.COc1ccc2c3c(c(=O)oc2c1)CNCC3>>COc1ccc2c3c(c(=O)oc2c1)CN(CCc1ccccc1)CC3,,CCOCC,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20020055631A1,CCOC(=O)c1ccc(N2CCN(C(=O)OCC(C)C)CC2)cc1>>CC(C)COC(=O)N1CCN(c2ccc(C(=O)O)cc2)CC1,,C1CCOC1,CO,[Na+].[OH-],,val
US20120053173A1,Cc1c(C(=O)C2CCCCC2)oc2cccc(F)c12>>Cc1c(C(O)C2CCCCC2)oc2cccc(F)c12,,C1CCOC1,CO,[BH4-].[Na+],,val
US20020016466A1,CC(C(=O)c1ccc(OCc2ccccc2)cc1)N1CCC(O)(c2ccccc2)CC1.O=C(O)[C@](O)(C(=O)c1ccccc1)[C@](O)(C(=O)O)C(=O)c1ccccc1>>C[C@@H](C(=O)c1ccc(OCc2ccccc2)cc1)N1CCC(O)(c2ccccc2)CC1.O=C(O)[C@](O)(C(=O)c1ccccc1)[C@](O)(C(=O)O)C(=O)c1ccccc1,,CC(C)=O,,,,val
US20070149533A1,COc1ccc(CN(C)c2cc(Oc3ccc4c(c3)CC(C(=O)Nc3cccc(C(C)(C)C)c3)CC4)ccn2)cc1>>CNc1cc(Oc2ccc3c(c2)CC(C(=O)Nc2cccc(C(C)(C)C)c2)CC3)ccn1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20110288116A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(O)C1Cc1c[nH]c2ncccc12>>CC(=O)OC1CCN(C(=O)OC(C)(C)C)C1Cc1c[nH]c2ncccc12,CN(C)c1ccncc1,ClCCl,,,,val
US20100278733A1,O=C(C=Cc1ccc(Br)s1)c1ccc([N+](=O)[O-])cc1>>Nc1ccc(C(=O)C=Cc2ccc(Br)s2)cc1,,CCO,,Cl[Sn]Cl,,val
US20100087429A1,CC(C)(O)C#Cc1cnc2c(c1)[C@]1(COC(N)=N1)c1cc(OS(=O)(=O)C(F)(F)F)ccc1O2.OB(O)c1ccccc1>>CC(C)(O)C#Cc1cnc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3ccccc3)ccc1O2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20070219370A1,Cc1cccc(Cl)c1N.O=C(Cl)CCl>>Cc1cccc(Cl)c1NC(=O)CCl,,ClCCl,,Cl,c1ccncc1,val
US20060040972A1,COc1ccc(Cc2n[nH]c3c2c(=O)n(-c2ccccc2)c2ncccc32)cc1>>O=c1c2c(Cc3ccc(O)cc3)n[nH]c2c2cccnc2n1-c1ccccc1,,CC(=O)O,,Br,O,val
US20030114683A1,C1CCOC1.CCOCC.COc1ccccc1Br.O=C1Nc2ccc(Cl)cc2C1=O.[Mg]>>COc1ccccc1C1(O)C(=O)Nc2ccc(Cl)cc21.COc1ccccc1[Mg]Br,,C1CCOC1,,[Cl-].[NH4+],,val
US20080139539A1,COc1ccc2ncc(F)c(N3CCN(CCNC(=O)OC(C)(C)C)CC3)c2n1>>COc1ccc2ncc(F)c(N3CCN(CCN)CC3)c2n1,,CO,,C1COCCO1,Cl,val
US20090062251A1,Clc1ccccc1C(c1ccccc1)c1ccccc1.O=C1CC[C@@H](CO)N1>>O=C1CC[C@@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)N1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US05521170,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3CCC(=O)N(CC(=O)N4CCN(C)CC4)c4ccccc43)cc2)cc1>>Cc1ccc(-c2ccccc2C(=O)N(C(=O)OC(C)(C)C)c2ccc(C(=O)N3CCC(=O)N(CC(=O)N4CCN(C)CC4)c4ccccc43)cc2)cc1,CN(C)c1ccncc1,CC(C)=O,,CCN(CC)CC,,val
US20090118259A1,COC(=O)c1ccc(F)c([N+](=O)[O-])c1.NCCO>>COC(=O)c1ccc(NCCO)c([N+](=O)[O-])c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20100181527A1,C#CCBr.CC1(C)NC(C)(C)C(=O)NC1=O>>C#CCN1C(=O)C(C)(C)NC(C)(C)C1=O,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US20050245503A1,CN1CC[C@@H](NC(=O)c2cnc(NN)c(Cl)c2)C1=O.NC1c2cccnc2CCc2c(F)cccc21.O=C(n1ccnc1)n1ccnc1>>CN1CC[C@@H](NC(=O)c2cnc(NNC(=O)NC3c4cccnc4CCc4c(F)cccc43)c(Cl)c2)C1=O,,CN(C)C=O,,,,val
US06075018,CC(=O)OC(C)=O.COc1cc2c(cc1OC)C(C=Cc1ccc(N)cc1)=NNC(C)C2>>COc1cc2c(cc1OC)C(C=Cc1ccc(NC(C)=O)cc1)=NN(C(C)=O)C(C)C2,,CC(=O)OC(C)=O,,,,val
US20140329798A1,CCOc1cnc(N2CCC([C@H]3C[C@H]3CCO)CC2)nc1.Oc1cc(F)c(Br)c(F)c1>>CCOc1cnc(N2CCC([C@H]3C[C@H]3CCOc3cc(F)c(Br)c(F)c3)CC2)nc1,,ClCCl,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110224202A1,COc1cc(OC=O)cc(OC)c1C>>COc1cc(O)cc(OC)c1C,,CO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20040092737A1,COCN1c2cc(-c3nnn[nH]3)ccc2Sc2nccnc21>>c1cnc2c(n1)Nc1cc(-c3nnn[nH]3)ccc1S2,,CC(=O)O,,,,val
US20050054701A1,CC(C)N=C(NC(C)C)OC(C)(C)C.O=C(O)c1cnc(Cl)cc1Nc1ccc(Br)cc1Cl>>CC(C)(C)OC(=O)c1cnc(Cl)cc1Nc1ccc(Br)cc1Cl,,C1CCOC1,CCOC(C)=O,Cl,,val
US20120010182A1,CC(C)(C)OC(=O)N1CC(OS(C)(=O)=O)C1.NN>>CC(C)(C)OC(=O)N1CC(NN)C1,,O,,,,val
US20100152098A1,CC(C)(C)OC(=O)N[C@@H](CC1CCN(C(=O)OC(C)(C)C)CC1)C(=O)O.Nc1cnc2ccccc2c1>>CC(C)(C)OC(=O)N[C@@H](CC1CCN(C(=O)OC(C)(C)C)CC1)C(=O)Nc1cnc2ccccc2c1,,ClCCl,,COc1nc(OC)nc([N+]2(C)CCOCC2)n1.[Cl-],,val
US04017621,O=C1COC(CN2c3ccccc3CCc3ccccc32)CN1Cc1ccccc1>>c1ccc(CN2CCOC(CN3c4ccccc4CCc4ccccc43)C2)cc1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20090137603A1,N#Cc1ccnc(Cl)c1.OCCSc1nc[nH]n1>>N#Cc1ccnc(OCCSc2nc[nH]n2)c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US05561118,C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.O=C1c2ccccc2C(=O)N1O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(OCc1ccccc1)N1CCCC(ON2C(=O)c3ccccc3C2=O)C1,,C1CCOC1,,,,val
US20060074237A1,Cc1cccc(N)n1.O=S(=O)(Cl)c1ccc2ccccc2c1>>Cc1cccc(NS(=O)(=O)c2ccc3ccccc3c2)n1,,c1ccncc1,,,,val
US20140336377A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCC(O)c1ccc(OCC(F)(F)F)nc1>>Cc1ccc(S(=O)(=O)OCC(O)c2ccc(OCC(F)(F)F)nc2)cc1,,ClCCl,,O,c1ccncc1,val
US20130079321A1,CC(=O)NC1(C)CCCN(c2c([N+](=O)[O-])cnn2C)CC1>>CC(=O)NC1(C)CCCN(c2c(N)cnn2C)CC1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20100069307A1,CC(C)(C)OCC(C(=O)OC(C)(C)C)n1cnc2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2c1=O>>O=C(O)C(CO)n1cnc2ccc(N3CCNCC3)cc2c1=O,,COc1ccccc1,,O=C(O)C(F)(F)F,,val
US20140249104A1,C=Cc1ncc(OCc2ccc(OC)cc2)cc1C>>C=Cc1ncc(O)cc1C,,COc1ccccc1,,O=C(O)C(F)(F)F,,val
US20060235222A1,CC(O)(c1cc2ncccc2o1)C1CC1.CS(=O)(=O)Nc1cccc2cc[nH]c12>>CC(c1cc2ncccc2o1)(c1c[nH]c2c(NS(C)(=O)=O)cccc12)C1CC1,,CCOCC,ClCCl,O=C(O)C(F)(F)F,,val
US20150299203A1,COc1ccc(CN(CC2CCOCC2)c2nc(N(C)C)nc3c(-c4ccc(C(=O)NC5CC5)c(C)c4)cnn23)cc1>>Cc1cc(-c2cnn3c(NCC4CCOCC4)nc(N(C)C)nc23)ccc1C(=O)NC1CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100190764A1,COC(=O)C1(O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1>>O=C(O)C1(O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1,,CO,O,[Li+].[OH-],,val
US20150152127A1,CN(C(=O)OC(C)(C)C)C1=N[C@H]2[C@H](O[C@H](C=O)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)S1.C[Si](C)(C)C(F)(F)F>>CN(C(=O)OC(C)(C)C)C1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(F)(F)F)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)S1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050032772A1,CCOC(=O)N1CCC(C#N)(NC(=O)C(CC2CCCCC2)NC(=O)C2CCN(C(=O)OC(C)(C)C)CC2)CC1>>CCOC(=O)N1CCC(C#N)(NC(=O)C(CC2CCCCC2)NC(=O)C2CCNCC2)CC1,,C1COCCO1,Cl,,,val
US20130059834A1,CONC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12>>CONC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(F)ccc34)nc12,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US07101892B2,CC(C)(CC=O)CS(=O)(=O)c1ccccc1.FC(F)(F)C1CCNCC1>>CC(C)(CCN1CCC(C(F)(F)F)CC1)CS(=O)(=O)c1ccccc1,,CO,,[BH3-]C#N.[Na+],,val
US05484928,CC(C)(O/N=C(\C(=O)O)c1csc(N)n1)C(=O)OC(c1ccccc1)c1ccccc1.c1ccc2sc(SSc3nc4ccccc4s3)nc2c1>>CC(C)(O/N=C(\C(=O)Sc1nc2ccccc2s1)c1csc(N)n1)C(=O)OC(c1ccccc1)c1ccccc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160185778A1,BrCCCCBr.CC(C)(C)OC(=O)N1CCc2[nH]nc(N)c2C1>>CC(C)(C)OC(=O)N1CCc2[nH]nc(N3CCCC3)c2C1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110288116A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(c1c[nH]c2cc(F)ccc12)C1CC(O)CN1C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N1CC(O)CC1C(=O)c1c[nH]c2cc(F)ccc12,[Pd],CO,,[H][H],,val
US20140288066A1,CC(=O)O.CCSc1nc2c(c(=O)[nH]1)C(C)SC2>>CC1SCc2[nH]c(=O)[nH]c(=O)c21,,Cl,,,,val
US05444084,CCOC(=O)CP(=O)(OCC)OCC.COC(C)(C)C#C/C=C/CBr>>CCOC(=O)C(C/C=C/C#CC(C)(C)OC)P(=O)(OCC)OCC,,CCO,,CC(=O)O,[H-].[Na+],val
US20010021708A1,CC(C)(C)OC(=O)N1CCC2(CC1)NC(=O)NC2=O.COC(=O)[C@H](CO)NC(c1ccccc1)(c1ccccc1)c1ccccc1>>COC(=O)[C@H](CN1C(=O)NC2(CCN(C(=O)OC(C)(C)C)CC2)C1=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090131659A1,CC(=O)c1csc(-c2ccc(Cl)c(Cl)c2)c1O.NNC(=O)c1ccc(C(=O)NCCN2CCCC2)s1>>CC(=NNC(=O)c1ccc(C(=O)NCCN2CCCC2)s1)c1csc(-c2ccc(Cl)c(Cl)c2)c1O,,CS(C)=O,,,,val
US20090062274A1,C=CC(=O)OCC.Cc1nc(N)nc(NCc2ccccc2)c1I>>CCOC(=O)/C=C/c1c(C)nc(N)nc1NCc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,CCN(CC)CC,,val
US04609669,O=S(=O)(OCC(F)(F)F)c1ccccc1.Oc1c(Cl)cc(S)cc1Cl>>Oc1c(Cl)cc(SCC(F)(F)F)cc1Cl,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20110306618A1,CSc1nccc(-c2cnc3c(C(C)(C)O)cccn23)n1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nccc(-c2cnc3c(C(C)(C)O)cccn23)n1,,ClCCl,,,,val
US20050113413A1,COc1ccncc1CN1CCC(N(C(=O)OC(C)(C)C)C(C)C)CC1>>COc1ccncc1CN1CCC(NC(C)C)CC1,,C1COCCO1,,Cl,,val
US04749712,COc1ccc(-c2cc(C3(O)CCCCC3)sc2-c2ccc(OC)cc2)cc1>>COc1ccc(-c2cc(C3CCCCC3)sc2-c2ccc(OC)cc2)cc1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20070265225A1,CC1(C)CC[C@@H](c2cc(F)cc(F)c2)N(CC(=O)O)C1=O.C[Si](C)(C)CCOCN1C(=O)[C@@]2(Cc3ccc(N)cc3C2)c2cccnc21>>CC1(C)CC[C@@H](c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)N(COCC[Si](C)(C)C)c3ncccc32)C1=O,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US05559106,CCOP(=O)(Cc1nnc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n12)OCC>>O=c1[nH]c2cc(C(F)(F)F)ccc2n2c(CP(=O)(O)O)nnc12,,CC#N,,C[Si](C)(C)Br,,val
US04333730,CC(=O)Nc1cc([N+](=O)[O-])ccc1OCCCN1C(=O)c2ccccc2C1=O>>CC(=O)Nc1cc([N+](=O)[O-])ccc1OCCCN,,CCCO,,NN,O,val
US20150336986A1,CS(=O)(=O)Cl.Cn1c(=O)c2c(-c3ccccc3)n([C@@H](CO)CSC(c3ccccc3)(c3ccccc3)c3ccccc3)cc2n(C)c1=O>>Cn1c(=O)c2c(-c3ccccc3)n([C@@H](COS(C)(=O)=O)CSC(c3ccccc3)(c3ccccc3)c3ccccc3)cc2n(C)c1=O,,ClCCl,,CCN(CC)CC,,val
US20110190336A1,CCOC(=O)CN.O=[N+]([O-])c1cnccc1Cl>>CCOC(=O)CNc1ccncc1[N+](=O)[O-],,CC#N,,CCN(C(C)C)C(C)C,,val
US20020132820A1,C=CCNC(N)=O.CCOC(=O)CC(C)=O>>C=CCn1c(=O)cc(C)[nH]c1=O,Cl,CCO,CO,[K+].[OH-],,val
US20140206663A1,CCOC(=O)C(C)N1C(=O)COc2ccc(OC(C)=O)cc21>>CCOC(=O)C(C)N1C(=O)COc2ccc(O)cc21,,C1CCOC1,CCOC(C)=O,C1COCCN1,,val
US20010027196A1,CC#N.COC(=O)c1ccc(Br)o1>>N#CCC(=O)c1ccc(Br)o1,,C1CCOC1,,Cl,[H-].[Na+],val
US20020143009A1,CC(=O)NC[C@H]1CN(c2ccc3c(c2)CC(C)N3)C(=O)O1.CC(=O)OCC(=O)Cl>>CC(=O)NC[C@H]1CN(c2ccc3c(c2)CC(C)N3C(=O)CO)C(=O)O1,,CO,ClCCl,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20120046267A1,CC(C)(C)Sc1c(C=NO)ccc(I)c1Br>>Brc1c(I)ccc2cnsc12,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120114739A1,C[Si](C)(C)CCOCn1cc(C2CCC3(CC2)OCCO3)cn1>>C[Si](C)(C)CCOCn1cc(C2CCC(=O)CC2)cn1,,C1COCCO1,CCO,Cl,O,val
US20140088100A1,COc1cc(OC)c(Cl)c(-c2cc3cnc(S(C)(=O)=O)nc3n(C)c2=O)c1Cl.Cc1cccc([N+](=O)[O-])c1N>>COc1cc(OC)c(Cl)c(-c2cc3cnc(Nc4c(C)cccc4N)nc3n(C)c2=O)c1Cl,,CCOC(C)=O,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US05175301,ClCCl.ClCc1ccc(Cl)nc1Cl.ClCc1cnc(Cl)s1>>CNCc1cnc(Cl)s1,,ClCCl,,,,val
US03984465,CC1c2cc(O)c(Cl)c(Cl)c2C(=O)C1(C)C.O=C(O)CI>>CC1c2cc(OCC(=O)O)c(Cl)c(Cl)c2C(=O)C1(C)C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06001913,C=C(C)C(=O)Cl.CCC=CCCCCCCCCCCCO>>C=C(C)C(=O)OCCCCCCCCCCCC=CCC,,ClCCl,,CCN(CC)CC,,val
US20070213323A1,COc1ccc(-c2ccc(=O)n(Cc3ccc(C#C[Si](C)(C)C)nc3)c2)cc1>>C#Cc1ccc(Cn2cc(-c3ccc(OC)cc3)ccc2=O)cn1,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110275610A1,O=C(O)C1CNC1.O=Cc1ccc(-c2noc(-c3cnn(-c4ccccc4)c3C(F)(F)F)n2)cc1>>O=C(O)C1CN(Cc2ccc(-c3noc(-c4cnn(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1,,CO,ClCCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150087663A1,C[C@H](N)c1nc2cccc(Cl)c2c(=O)n1C1CC1.Cc1noc(-c2c(N)ncnc2Cl)n1>>Cc1noc(-c2c(N)ncnc2N[C@@H](C)c2nc3cccc(Cl)c3c(=O)n2C2CC2)n1,,CCCCO,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US04239901,CCOC(=O)C(C)c1ccc(-n2cccn2)c(Cl)c1.ClCl>>CCOC(=O)C(C)c1ccc(-n2cc(Cl)cn2)c(Cl)c1,,ClCCl,,,,val
US20120225866A1,CC(C)(C)O.CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(C=O)ccc21>>CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(C(=O)O)ccc21,,CC(C)(C)O,O,CC=C(C)C,[Na+].[O-]Cl,val
US20120264923A1,COC(=O)CCC=C(C)CCCC(C)CCCC(C)CCCC(C)C.O=C1O[C@H]([C@@H](O)CO)C(O)=C1O>>CC(=CCCC(=O)OC1=C(O)[C@@H]([C@@H](O)CO)OC1=O)CCCC(C)CCCC(C)CCCC(C)C,,O=S(=O)(O)O,,O,,val
US20150133457A1,COCCOc1c(F)cc(Nc2nc(Oc3cccc([N+](=O)[O-])c3)c3ccn(COC(=O)C(C)(C)C)c3n2)cc1F>>COCCOc1c(F)cc(Nc2nc(Oc3cccc([N+](=O)[O-])c3)c3cc[nH]c3n2)cc1F,,O,,CO,[Na+].[OH-],val
US20060058553A1,CCOC(=O)c1cc(N)cc(-c2ccc(C(N)=O)cc2)c1.O=C(Cl)c1ccccc1>>CCOC(=O)c1cc(NC(=O)c2ccccc2)cc(-c2ccc(C(N)=O)cc2)c1,,ClCCl,,CC(=O)N(C)C,,val
US05214156,COc1cccc2c1CC[C@H](NCC1CC1)[C@@H]2C.O=C(Cl)C1CC1>>COc1cccc2c1CC[C@H](N(CC1CC1)CC1CC1)[C@@H]2C.Cl,,CCOCC,,CCN(CC)CC,,val
US20110105475A1,BrBr.COc1cccc(C)c1C=O>>COc1ccc(Br)c(C)c1C=O,[Fe],ClC(Cl)(Cl)Cl,,O,,val
US20130157996A1,CC(C)(C)S(=O)N=Cc1ccc(I)cc1.FC(F)(F)c1cccnc1Br>>CC(C)(C)S(=O)NC(c1ccc(I)cc1)c1ncccc1C(F)(F)F,,C1CCOC1,,[Li]CCCC,,val
US05464865,O=Cc1ccc(O)cc1.OCCCCCCOc1ccc2ccccc2c1>>O=Cc1ccc(OCCCCCCOc2ccc3ccccc3c2)cc1,,C1CCOC1,CCCCCC,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090136448A1,COC(=O)c1sc(I)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C(C)C>>CC1CCC(C(=O)N(c2cc(I)sc2C(=O)O)C(C)C)CC1,,CO,,C1CCOC1,[Na+].[OH-],val
US20090270359A1,CI.N#Cc1cc(Br)c[nH]c1=O>>Cn1cc(Br)cc(C#N)c1=O,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20080287394A1,BrBr.CCOC(=O)c1c(OCc2ccccc2)c2n(c1C(C)=O)CCN(C)C2=O>>CCOC(=O)c1c(OCc2ccccc2)c2n(c1C(=O)CBr)CCN(C)C2=O,CC(=O)O,ClC(Cl)Cl,,Br,O=C([O-])O.[Na+],val
US20160211456A1,COc1ccc2c(c1)c1ccccc1c1cc3c(cc21)=C1C(=CC(B2OC(C)(C)C(C)(C)O2)=CC12c1ccccc1-c1ccccc12)C=3.Clc1nc(-c2ccccc2)nc(-c2ccccc2)n1>>COc1ccc2c(c1)c1ccccc1c1cc3c(cc21)=C1C(=CC(c2nc(-c4ccccc4)nc(-c4ccccc4)n2)=CC12c1ccccc1-c1ccccc12)C=3,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20070099990A1,Cc1cc2c(c(C)c1NCc1ccccc1)C(c1ccccc1)CO2>>Cc1cc2c(c(C)c1N)C(c1ccccc1)CO2,,CCCCCC,CCOC(C)=O,,,val
US20120277217A1,NC1CCOCC1.Nc1ccc(CCOc2ccccc2-c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(Nc1ccc(CCOc2ccccc2-c2c[nH]cn2)cc1)NC1CCOCC1,,CCN(CC)CC,ClCCl,O=C([O-])O.[Na+],,val
US06569888B1,COC(=O)c1cc2c(OC(C)=O)c(OC)ccc2[nH]1.Clc1ccc(CBr)cc1Cl>>COC(=O)c1cc2c(OC(C)=O)c(OC)ccc2n1Cc1ccc(Cl)c(Cl)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080269208A1,CC(C)(C)OC(=O)N1CCC[C@@H]1CN.O=C(Cl)CCl>>CC(C)(C)OC(=O)N1CCC[C@@H]1CNC(=O)CCl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140131663A1,COc1ccc(Cl)cc1B(O)O.Nc1cccnc1Br>>COc1ccc(Cl)cc1-c1ncccc1N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,,,val
US20140228348A1,CCOP(=O)(OCC)C(F)(F)Br.OCc1cc(Br)ccc1S>>OCc1cc(Br)ccc1SC(F)F,,CC#N,,O,[K+].[OH-],val
US20120258950A1,C[Si](C)(C)CCOCCl.Ic1c[nH]c2ncncc12>>C[Si](C)(C)CCOCn1cc(I)c2cncnc21,,CN(C)C=O,,O,[H-].[Na+],val
US05278316,COC(=O)C(Cc1c[nH]c2ccccc12)NCOC(C)[Si](C)(C)C.O=C(Cl)OC1C2CC3CC(C2)CC1C3>>COC(=O)C(Cc1c[nH]c2ccccc12)N(COC(C)[Si](C)(C)C)C(=O)OC1C2CC3CC(C2)CC1C3,,C1CCOC1,O,CCN(C(C)C)C(C)C,,val
US20120070505A1,C#CCO.CCCCCCCCCCCCCCCCCCBr>>C#CCOCCCCCCCCCCCCCCCCCC,,CN(C)C=O,ClCCl,CO,[H-].[Na+],val
US20030069297A1,CN(C)CCN.Cc1c(C(=O)N2CCOCC2)c[nH]c1/C=C1\C(=O)Nc2cccc(-c3cccc(CC(=O)O)c3)c21>>Cc1c(C(=O)N2CCOCC2)c[nH]c1/C=C1\C(=O)Nc2cccc(-c3cccc(CC(=O)NCCN(C)C)c3)c21,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20130150343A1,CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C.O[C@H]1CCCN(c2nnc3ccc(F)cn23)C1>>CC(C)[Si](O[C@H]1CCCN(c2nnc3ccc(F)cn23)C1)(C(C)C)C(C)C,,ClCCl,,CCN(CC)CC,,val
US05484942,O=C(Cl)Cc1ccccc1.O=S1(=O)CCC(c2ccccc2)(c2ccccc2)C2CNCC21>>O=C(Cc1ccccc1)N1CC2C(C1)S(=O)(=O)CCC2(c1ccccc1)c1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US20120115817A1,COC(=O)c1ccccc1O.NN>>NNC(=O)c1ccccc1O,,CO,,ClCCl,O,val
US20090291959A1,Cc1nccc2ccccc12.O=C1CCC(=O)N1Br>>BrCc1nccc2ccccc12,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,,,val
US06809097B1,COc1ccc(NC=C2C(=O)OC(C)(C)OC2=O)cc1OCCCN1CCOCC1>>COc1cc2c(=O)cc[nH]c2cc1OCCCN1CCOCC1,,c1ccc(Oc2ccccc2)cc1,,,,val
US20160083422A1,CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)N1c2ccccc2C[C@H]1C(=O)O.NCc1cn[nH]n1>>CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)N1c2ccccc2C[C@H]1C(=O)NCc1c[nH]nn1,,CN(C)C=O,,Cl,,val
US20050245530A1,CN(C)CCCNc1cc(C(O)c2ccc(NC(=O)OC(C)(C)C)cc2)ccn1>>CN(C)CCCNc1cc(C(O)c2ccc(N)cc2)ccn1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20040259894A1,CI.CNc1nc(C)c(C(C)=O)s1>>CC(=O)c1sc(N(C)C)nc1C,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20140171429A1,CCOC(=O)C1=C(C)NC(Cc2c(Cl)cccc2Cl)CC1=O>>CCOC(=O)c1c(C)[nH]c(Cc2c(Cl)cccc2Cl)cc1=O,,C1CCOC1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20100222349A1,C=CC(=O)OC.CCCCc1cc(O[C@@H]2CCNC2)c2ncccc2c1>>CCCCc1cc(O[C@@H]2CCN(CCC(=O)OC)C2)c2ncccc2c1,,C1CCOC1,,,,val
US04611056,CC(=O)Cl.Oc1cc2c(c3ccccc13)Nc1ccccc1S2>>CC(=O)N1c2ccccc2Sc2cc(O)c3ccccc3c21,,CN(C)C=O,,CCOCC,,val
US20050267199A1,CC(C)c1cccc(C2(NC[C@@H](O)[C@H](Cc3cc(F)cc(F)c3)NC(=O)OC(C)(C)C)CCCCC2)c1.Cl.ClCCl>>CC(C)c1cccc(C2(NC[C@@H](O)[C@@H](N)Cc3cc(F)cc(F)c3)CCCCC2)c1.Cl.Cl,,CCOCC,ClCCl,O=C(O)C(F)(F)F,,val
US20110021489A1,COC(=O)C1CNCC(c2ccc(OC(F)(F)F)cc2)C1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>COC(=O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)Oc2ccc([N+](=O)[O-])cc2)C1,,ClCCl,,CCN(CC)CC,,val
US20140294898A1,COC(=O)[C@H](CO)NC(c1ccccc1)(c1ccccc1)c1ccccc1.Cc1cccc(O)c1>>COC(=O)[C@H](COc1cccc(C)c1)NC(c1ccccc1)(c1ccccc1)c1ccccc1,,Cc1ccccc1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100298342A1,CN.C[C@H]1C[C@]2(CCN1C(=O)OCc1ccccc1)C(N)=NC(=O)N2c1cccc(F)c1>>CNC1=NC(=O)N(c2cccc(F)c2)[C@@]12CCN(C(=O)OCc1ccccc1)[C@@H](C)C2,,O=C([O-])O,[Na+],,,val
US20030153568A1,CCNC(=O)Nc1nc2ccc(-c3cccc(N)c3)cc2s1.O=C=Nc1ccccc1>>CCNC(=O)Nc1nc2ccc(-c3cccc(NC(=O)Nc4ccccc4)c3)cc2s1,,Cc1ccccc1,,CCN(CC)CC,,val
US20060148888A1,O=C1CCOc2cc(S(=O)(=O)c3cccc(F)c3)ccc21>>O=S(=O)(c1cccc(F)c1)c1ccc2c(c1)OCCC2O,,C1CCOC1,,[BH4-].[Na+],,val
US05962744,CC(C)(C)[Si](C)(C)Cl.O=CCCCC1CCCC(O)O1>>CC(C)(C)[Si](C)(C)OC1CCCC(CCCC=O)O1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20140163008A1,COc1nc2cc(C(F)(F)F)ccn2c1C(=O)c1ccc2c(c1)COc1cc(F)ccc1/C2=C(\C)C#N>>COc1nc2cc(C(F)(F)F)ccn2c1C(O)c1ccc2c(c1)COc1cc(F)ccc1/C2=C(\C)C#N,,C1CCOC1,CCO,O,[BH4-].[Li+],val
US07655670B2,CC(=O)OC(C)=O.CC(C)(C)OC(=O)c1ccc2c(c1)C1(CCNCC1)C(=O)N2CCOC1CCCCO1>>CC(=O)OCCN1C(=O)C2(CCNCC2)c2cc(C(=O)OC(C)(C)C)ccc21,,CO,ClCCl,CCN(CC)CC,Cl,val
US20140256739A1,COc1nc(NC(=O)OC(C)(C)C)cc(C)c1CNC(=O)c1cc(Br)cc2c1c(C)cn2C(C)C>>Cc1cc(N)[nH]c(=O)c1CNC(=O)c1cc(Br)cc2c1c(C)cn2C(C)C,,CC#N,,C[Si](C)(C)I,,val
US20130190340A1,COC(=O)CBr.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1O>>COC(=O)COc1c(OC)cc(Cc2cnc(N)nc2N)cc1OC,,CN(C)C=O,,[H-].[Na+],,val
US20090004209A1,NC1CCC(=O)NC1=O.O=C(O)c1cccc(OCc2cccc(F)c2)c1C(=O)O>>O=C1CCC(N2C(=O)c3cccc(OCc4cccc(F)c4)c3C2=O)C(=O)N1,,c1ccncc1,,Cl,,val
US20100311966A1,CCOC(=O)c1sc(N2CC(CNC(=O)OCc3ccccc3)C2)nc1C>>CCOC(=O)c1sc(N2CC(CN)C2)nc1C,,CC(=O)O,,Br,[Na+].[OH-],val
US20100137281A1,CCCOc1cc(=O)n(CC(=O)c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1F.O=C([O-])O.[NH3+]O>>CCCOc1cc(=O)n(CC(=O)c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1F,,ClC(Cl)Cl,,CS(C)=O,[Cl-].[Na+],val
US20110294781A1,C1COCCN1.Clc1cc(Cl)n2nc(-c3ccccn3)cc2n1>>Clc1cc(N2CCOCC2)n2nc(-c3ccccn3)cc2n1,,C1COCCO1,O,,,val
US20160194316A1,CCN(c1cc(Cl)cc(C(=O)OC)c1C)C1CCN(C(=O)OC(C)(C)C)CC1>>CCN(c1cc(Cl)cc(C(=O)OC)c1C)C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20130281434A1,COc1cncc(-c2cc(-c3nc4cc(C)c([C@@H](COC(=O)C(C)(C)C)OC(C)(C)C)c(-c5ccc(Cl)cc5)c4s3)ccn2)c1>>COc1cncc(-c2cc(-c3nc4cc(C)c([C@@H](CO)OC(C)(C)C)c(-c5ccc(Cl)cc5)c4s3)ccn2)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20140163066A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.O=C(O)[C@@H]1CC[C@@H](CO)CC1>>CC(C)(C)[Si](C)(C)OC[C@@H]1CC[C@@H](C(=O)O)CC1,,ClCCl,,Cc1cccc(C)n1,,val
US20150158815A1,COc1cc(B(O)O)ccn1.NC(=O)C(Nc1cncc(Br)c1)c1ccccc1>>COc1cc(-c2cncc(NC(C(N)=O)c3ccccc3)c2)ccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20140314669A1,CC(C)(C)OC(=O)N1CCC(CCC(=O)N2CCC[C@@H](C(=O)O)C2)CC1.O=C1CCC(=O)N1O>>CC(C)(C)OC(=O)N1CCC(CCC(=O)N2CCC[C@@H](C(=O)ON3C(=O)CCC3=O)C2)CC1,,COCCOC,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20090259048A1,COc1ccc(C(=O)CC(=O)c2cccc(OC)c2OC)cc1>>O=c1cc(-c2ccc(O)cc2)oc2c(O)cccc12,,CC(=O)O,O,,,val
US03952006,CCc1cc2c(s1)NC(=S)CN=C2c1ccccc1Cl.NN>>CCc1cc2c(s1)N=C(NN)CN=C2c1ccccc1Cl,,CCO,,O,,val
US05250528,O=C(Cl)c1cccs1.O=NN1CCNCC1>>O=NN1CCN(C(=O)c2cccs2)CC1,,C1COCCO1,O,CCOC(C)=O,c1ccncc1,val
US20040082796A1,CCOC(=O)[C@@H](N)CS.COc1ccc(C#N)c(OC)c1>>CCOC(=O)[C@@H]1CSC(c2ccc(OC)cc2OC)=N1,,CCO,,CCN(CC)CC,,val
US06239131B1,CC(C)(CCl)C(=O)Cl.CCOC(=O)c1cccc(NC(=O)NC2CNc3ccc(C)cc3N(CC(=O)c3ccccc3C)C2=O)c1>>CCOC(=O)c1cccc(NC(=O)NC2CN(C(=O)C(C)(C)CCl)c3ccc(C)cc3N(CC(=O)c3ccccc3C)C2=O)c1,,ClCCCl,,c1ccncc1,,val
US20140329798A1,CCOCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)OC)c(F)c3)CC2)nc1>>CCOCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)O)c(F)c3)CC2)nc1,,C1CCOC1,,CO,[Li+].[OH-],val
US04840965,BrCc1ccccc1.Oc1cccc2c1OCO2>>c1ccc(COc2cccc3c2OCO3)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04540699,CCCCn1ccc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)cc1=O.Cc1[nH]cnc1CSCCN>>CCCCn1ccc(Cc2cnc(NCCSCc3nc[nH]c3C)[nH]c2=O)cc1=O,,c1ccncc1,,,,val
US20090176823A1,CC(C)(C)OC(=O)N(Cc1cc(CC(=O)NC2CC2)ccc1Cl)C1CC1>>O=C(Cc1ccc(Cl)c(CNC2CC2)c1)NC1CC1,,ClCCl,,Cl,[Na+].[OH-],val
US20130324579A1,BrCCc1c[nH]c2ccccc12.CI>>Cn1cc(CCBr)c2ccccc21,,C1CCOC1,,[H-].[Na+],,val
US05866724,C=O.CC(=O)O.Cc1cc(Cc2cc(C)c(C)c(Cc3cc(C)c(O)cc3C)c2O)c(C)cc1O.O>>Cc1cc(Cc2cc(C)c(O)c(CO)c2C)c(O)c(Cc2cc(C)c(O)c(CO)c2C)c1C,,C1CCOC1,,[Na+].[OH-],,val
US04225315,COC(OC)N(C)C.Cc1cccc(C)c1NC(=O)NC(=N)NCc1ccccn1>>Cc1cccc(C)c1-n1cnc(NCc2ccccn2)nc1=O,,CC#N,,,,val
US20130109685A1,Fc1ccc(OCc2ccccc2)c(C2c3ccccc3CN2Cc2ccccc2)c1>>Oc1ccc(F)cc1C1NCc2ccccc21,[Pd],CCO,,,,val
US20120028953A1,CC(Cl)OC(=O)Cl.c1ccc(-c2ccc(OC3CN(C(c4ccccc4)c4ccccc4)C3)cc2)cc1>>Cl.c1ccc(-c2ccc(OC3CNC3)cc2)cc1,,ClCCl,,,,val
US20090042856A1,Cc1ccccc1-n1nc(-c2c(-c3ccc(F)cc3F)nn3c2NCC(CN(C)C)C3)ccc1=O>>Cc1ccccc1N1N=C(c2c(-c3ccc(F)cc3F)nn3c2NCC(CN(C)C)C3)CCC1=O,[Zn],CC(=O)O,,O=C([O-])O.[Na+],,val
US20060217387A1,Nc1ncc(-c2ccc(C(F)(F)F)cc2)cc1C(F)(F)F.O=CCCl>>FC(F)(F)c1ccc(-c2cc(C(F)(F)F)c3nccn3c2)cc1,,CCO,,O,O=C([O-])O.[Na+],val
US20150087639A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.NC(=O)c1ccc(N2CCOCC2)cc1>>NC(=S)c1ccc(N2CCOCC2)cc1,,C1CCOC1,,,,val
US20140371269A1,CC(C)(C)OC(=O)N1CC=C(c2cccc(OCc3ccccc3)n2)CC1>>CC(C)(C)OC(=O)N1CCC(c2cccc(O)n2)CC1,[Pd],CO,,,,val
US20030186924A1,CCCCCCCCCCCCCCCCCC(=O)Cl.OCC(O)CO>>CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO,,CN(C)C=O,,c1ccncc1,O=C([O-])O.[Na+],val
US06350892B1,Clc1ccc(C(OCCBr)c2ccc(Cl)cc2)cc1.OCCS>>OCCSCCOC(c1ccc(Cl)cc1)c1ccc(Cl)cc1,,CN(C)C=O,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US05340831,Cc1cccc(CCBr)c1.NC(=O)C(c1ccccc1)(c1ccccc1)C1CCNC1>>Cc1cccc(CCN2CCC(C(C(N)=O)(c3ccccc3)c3ccccc3)C2)c1,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20080160344A1,C1CCOC1.CCCCC(CC)COc1ccc2c(Br)c3cc(OCC(CC)CCCC)ccc3c(Br)c2c1.Cc1ccccc1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCC(CC)COc1ccc2c(-c3ccc(C=C(c4ccccc4)c4ccccc4)cc3)c3cc(OCC(CC)CCCC)ccc3c(-c3ccc(C=C(c4ccccc4)c4ccccc4)cc3)c2c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20090234001A1,CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1ccc2cc(C(=O)Cl)ccc2c1.CNC>>CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1ccc2cc(C(=O)N(C)C)ccc2c1,,O,,CCN(CC)CC,Cl,val
US20100184601A1,Brc1ccc(Br)c2n[se]nc12.O=[N+]([O-])O>>O=[N+]([O-])c1ccc(Br)c2n[se]nc12,,O,,,,val
US20080227773A1,Nc1ccc(N2CCN3CCC2CC3)cc1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1ccc(N2CCN3CCC2CC3)cc1,,CO,,,,val
US05527918,CCCCn1cc(C(=O)O)c2ccccc21>>O=C(O)c1c[nH]c2ccccc12,[Pd],,,,,val
US20160039825A1,CC(C)(C)OC(=O)N1CC=C(c2cc3n(n2)CCCN(C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3)CC1>>O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCn2nc(C3=CCNCC3)cc2C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05037829,CC(=O)Cl.COC(OC)c1cc(C(=O)c2ccccc2)ccc1N>>COC(OC)c1cc(C(=O)c2ccccc2)ccc1NC(C)=O,,O,,c1ccncc1,,val
US20060135504A1,CCI.Cc1ccc(-c2nnn[nH]2)cc1>>CCn1nnc(-c2ccc(C)cc2)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20070179175A1,N.O=C(O)c1ccc(Br)nc1>>NC(=O)c1ccc(Br)nc1,,CS(C)=O,,O,O=C(n1ccnc1)n1ccnc1,val
US20130196002A1,Br.Cn1c(-c2ccnc(Cl)c2)ncc(OCc2ccccc2)c1=O>>Cn1c(-c2ccnc(Br)c2)ncc(O)c1=O,,CC(=O)O,,,,val
US04638067,CC(=O)COc1c([N+](=O)[O-])ccc(F)c1C(C)=O>>CC(=O)c1c(F)ccc2c1OCC(C)N2,[Ni],CCO,,[H][H],,val
US20100113444A1,CCOC(=O)CNC(=O)c1c(O)[nH]c(=O)n(Cc2ccccc2)c1=O.CI>>Cn1c(O)c(C(=O)NCC(=O)O)c(=O)n(Cc2ccccc2)c1=O,,CN(C)C=O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20140343079A1,CCOC(=O)/C=C/c1ccc(C)c(-c2cc3c(cc2C)C(C)(C)CCC3(C)C)c1>>Cc1ccc(/C=C/C(=O)O)cc1-c1cc2c(cc1C)C(C)(C)CCC2(C)C,,CO,O,Cl,[K+].[OH-],val
US06534496B1,CC(=O)N1CCC(CCC(=O)c2ccc3c(c2)CN(C=O)CCO3)CC1>>CC(=O)N1CCC(CCC(=O)c2ccc3c(c2)CNCCO3)CC1,,CO,Cl,,,val
US20070087346A1,CCCC[Sn](CCCC)(CCCC)c1ccc(OCOC)cc1.Cc1ccc(S(=O)(=O)n2ncc3c4c(ccc32)C2=C(Br)C(=O)CCC2(Cc2ccccc2)C4)cc1>>COCOc1ccc(C2=C3c4ccc5c(cnn5S(=O)(=O)c5ccc(C)cc5)c4CC3(Cc3ccccc3)CCC2=O)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20090099156A1,COCCOc1ccc(C=O)cn1.O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCNC2)CC1>>COCCOc1ccc(CN2CCC[C@@H](CN3CCN(C(=O)Nc4ccc(Cl)c(Cl)c4)CC3)C2)cn1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100298298A1,COc1ccc(CNC(=O)c2cc(OCc3ccccc3)ccc2N(C(=O)OCC(C)C)C2CCN(C(=O)OC(C)(C)C)CC2)cc1OC>>COc1ccc(Cn2c(=O)c3cc(OCc4ccccc4)ccc3n(C3CCN(C(=O)OC(C)(C)C)CC3)c2=O)cc1OC,,ClCCCl,ClCCl,[Na+].[OH-],,val
US20160108030A1,CCOC(=O)c1nn(CC(=O)OC)c2c1[C@H]1C[C@H]1C2OCOC>>CCOC(=O)c1nn(CC(=O)OC)c2c1[C@H]1C[C@H]1C2O,,CC(=O)O,,O,,val
US20150232481A1,COc1ccc(F)c(F)c1CCO>>OCCc1c(O)ccc(F)c1F,,ClCCl,,O,,val
US05039333,CC(O)CC(=O)O.COC(=O)c1cc(C=O)cnc1C1=NC(C)(C(C)C)C(=O)N1>>COC(=O)c1cc(C2OC(=O)CC(C)O2)cnc1C1=NC(C)(C(C)C)C(=O)N1,,ClC(Cl)Cl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20010051622A1,O=C(O)[C@@H]1CN(C(=O)OCc2ccccc2)CCN1c1cc(Cl)c(Cl)cc1[N+](=O)[O-]>>O=C1Nc2cc(Cl)c(Cl)cc2N2CCNC[C@@H]12,[Fe],CC(=O)O,,,,val
US20140256546A1,Cc1cccc(-c2c(C(F)(F)F)cc[nH]c2=O)c1.Cn1ncc(Cl)c(Cl)c1=O>>Cc1cccc(-c2c(C(F)(F)F)ccn(-c3cnn(C)c(=O)c3Cl)c2=O)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20070207175A1,CCCCCCCC(=O)N(C)Cc1cccc(-c2ccc(/C=C/C(=O)OC)cc2OCCCC)c1>>CCCCCCCC(=O)N(C)Cc1cccc(-c2ccc(CCC(=O)OC)cc2OCCCC)c1,[Pd],CO,,,,val
US05958957,CSc1nnc(-c2ccc3ccccc3c2)s1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nnc(-c2ccc3ccccc3c2)s1,,ClCCl,,,,val
US20080009530A1,CC(C)Oc1cc(CCC(=O)O)n(Cc2ccc(Cl)cc2Cl)n1.NS(=O)(=O)c1ccc(C(F)(F)F)cc1>>CC(C)Oc1cc(CCC(=O)NS(=O)(=O)c2ccc(C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2Cl)n1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20060116364A1,ClCCN1CCCCC1.Oc1ccc(Br)c2ccccc12>>Brc1ccc(OCCN2CCCCC2)c2ccccc12,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080255152A1,CC(C)(C)CCBr.NC(=O)c1ccc(Oc2ccc3c(c2)CCCNC3)nc1>>CC(C)(C)CCN1CCCc2cc(Oc3ccc(C(N)=O)cn3)ccc2C1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20090054405A1,CN(C)c1cc(-c2ccc3nc(N)sc3c2)cnc1Cl.NCCN1CCOCC1.O=C(n1ccnc1)n1ccnc1>>CN(C)c1cc(-c2ccc3nc(NC(=O)NCCN4CCOCC4)sc3c2)cnc1Cl,,CN(C)C=O,ClCCl,,,val
US05488055,OC1CCC(CNCc2ccccc2)CC1>>NCC1CCC(O)CC1,[Pd],CO,,O=C[O-].[NH4+],,val
US20150239900A1,O=C(Cl)C(=O)Cl.O=C(O)c1ccc(Cl)cc1[N+](=O)[O-]>>O=C(Cl)c1ccc(Cl)cc1[N+](=O)[O-],CN(C)C=O,C1CCOC1,,,,val
US20070105919A1,COCCC(=O)c1sc(NC(=O)OC(C)(C)C)nc1-c1ccco1>>COCCC(=O)c1sc(N)nc1-c1ccco1,,O=C(O)C(F)(F)F,,,,val
US20060149061A1,Cc1ccc([N+](=O)[O-])cc1N.Clc1nccc(-c2cccnc2)n1>>Cc1ccc([N+](=O)[O-])cc1Nc1nccc(-c2cccnc2)n1,Cl,CCCCO,,[Na+].[OH-],,val
US20030018197A1,BrCc1ccccc1.Cc1nn(-c2ccccc2)c(Sc2cc(Cl)cc(Cl)c2)c1CO>>Cc1nn(-c2ccccc2)c(Sc2cc(Cl)cc(Cl)c2)c1COCc1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US04731471,CC(=O)OCCC1Cc2cc(O)c(Cl)c(Cl)c2C1=O.COC(=O)CBr>>COC(=O)COc1cc2c(c(Cl)c1Cl)C(=O)C(CCOC(C)=O)C2,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20130210811A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.Fc1ccc(Br)cc1>>CC(C)(C)OC(=O)N1CC=C(c2ccc(F)cc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O,O=C([O-])[O-].[K+].[K+],val
US20140336259A1,CCOC(=O)C(c1ccc(OCc2ccccc2)c(OC)c1)C(c1ccc(OCc2ccccc2)c(OC)c1)c1ccc(OCc2ccccc2)c(OC)c1>>COc1cc(C(CO)C(c2ccc(OCc3ccccc3)c(OC)c2)c2ccc(OCc3ccccc3)c(OC)c2)ccc1OCc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080039462A1,NO.O=Cc1ccccc1O>>O/N=C/c1ccccc1O,,CCO,,CCN(CC)CC,Cl,val
US06498251B1,CC(C)(C)OC(=O)NCC1CSc2ccccc2N1.O=C(Cl)CCl>>CC(C)(C)OC(=O)NCC1CSc2ccccc2N1C(=O)CCl,,ClCCl,,CCN(CC)CC,,val
US20040082603A1,COc1ccc2c(c1)C(=O)NC2>>O=C1NCc2ccc(O)cc21,,ClCCl,,BrB(Br)Br,CO,val
US20150322051A1,C1CCOC1.CCCC[C@H]([C@H](C=O)Cc1ccccc1)[C@H](C)O[Si](C)(C)C>>C=C[C@H](Cc1ccccc1)[C@@H](CCCC)[C@H](C)O,,C1CCOC1,,[Li]CCCC,,val
US20160218293A1,CC1(C)c2ccccc2-c2ccc(-c3cc(Br)ccc3-c3ccccc3)cc21>>CC1(C)C=CC=C2C=c3cc4c5ccccc5c5cc(Br)ccc5c4cc3=C21,Cl[Fe](Cl)Cl,ClCCl,,,,val
US06060475,COc1nc(C)cnc1N(C(=O)OCC(C)C)S(=O)(=O)c1cccnc1-c1ccc(C)cc1.O=C1CCC(=O)N1Br>>COc1nc(C)cnc1N(C(=O)OCC(C)C)S(=O)(=O)c1cccnc1-c1ccc(CBr)cc1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20100111900A1,CCOC(=O)[C@H]1CCC(=O)N1Cc1cc(OC)c(C(C)(C)C)cc1Br.OB(O)c1cccnc1OCc1ccccc1>>CCOC(=O)[C@H]1CCC(=O)N1Cc1cc(OC)c(C(C)(C)C)cc1-c1cccnc1OCc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,ClCCl,O=C([O-])[O-].[Na+].[Na+],,val
US20080221134A1,CCn1c(=O)[nH]c(=O)c2[nH]c(C#Cc3ccc(OC)c(OC)c3)nc21.COS(=O)(=O)OC>>CCn1c(=O)[nH]c(=O)c2c1nc(C#Cc1ccc(OC)c(OC)c1)n2C,,CN(C)C=O,,CCN(CC)CC,,val
US20090131431A1,CCOC(=O)c1ccoc1CCl.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CN>>CCOC(=O)c1ccoc1CNCc1c(CC)nc2c(cnn2CC)c1NC1CCOCC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US04663453,NC(=O)c1ccccc1N1CCc2cc(Cl)cc(N)c21>>O=C1Nc2cc(Cl)cc3c2N(CC3)c2ccccc21,,CO,ClCCl,,,val
US20020028814A1,CC(C)COC(=O)Cl.CCC(C)(C)C(=O)C(=O)C1CCCNN1.CCN(CC)CC.ClCCl>>CCC(C)(C)C(=O)C(=O)C1CCCNN1C(=O)CCCCCc1ccccc1,,ClCCl,,,,val
US20100323994A1,COC(=O)CBr.COc1ccc(CN(c2cc(N[C@@H]3CC[C@@H](N)CC3)nn3c(C(=O)Nc4ccncc4F)cnc23)C2CC2)cc1>>COC(=O)CN[C@@H]1CC[C@@H](Nc2cc(NC3CC3)c3ncc(C(=O)Nc4ccnc(F)c4)n3n2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20070027071A1,C=CCCC(C)(C)C(=O)OCC>>C=CCCC(C)(C)CO,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04397847,CC(=O)OC(C)=O.CC(C)(O)C(F)(F)CCO>>CC(=O)OCCC(F)(F)C(C)(C)O,,CO,,c1ccncc1,,val
US20080188565A1,Cc1cc(O[C@H](C/C=C\COCc2ccccc2)C(=O)N2C(=O)OC[C@@H]2C(C)C)ccc1F>>Cc1cc(O[C@H](CCCCO)C(=O)N2C(=O)OC[C@@H]2C(C)C)ccc1F,[Pd],CCO,,,,val
US20070249670A1,COC(=O)[C@H](CCC(C)(C)C)NC(=O)c1cc2ccccc2cc1N.Cc1cc(C)c(N=C=O)c(C)c1>>COC(=O)[C@H](CCC(C)(C)C)NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C,,c1ccncc1,,,,val
US20130324579A1,COC(Cn1cc([N+](=O)[O-])cn1)OC>>O=CCn1cc([N+](=O)[O-])cn1,,C1CCOC1,,Cl,,val
US20110166146A1,CCOC(=O)C(=O)Cl.NC(Cc1c(-c2ccc(Cl)cc2)nc2ccccn12)=NO>>CCOC(=O)c1nc(Cc2c(-c3ccc(Cl)cc3)nc3ccccn23)no1,,ClC(Cl)Cl,,,,val
US20150151022A1,Brc1ccc(CCOCc2ccccc2)cc1.Oc1ccc(Oc2ccccc2)cc1>>OCCc1ccc(Oc2ccc(Oc3ccccc3)cc2)cc1,,O,c1ccncc1,C1CCOC1,[Na+].[OH-],val
US20160002205A1,BrBr.OCc1ccc(Cl)c(F)c1>>Fc1cc(CBr)ccc1Cl,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US03962341,C1CCOC1.CC(C)=CC=O.Cc1ccc(S(=O)(=O)O)cc1>>CC1=CC(=O)C(=C(C)C)CC1,,C1CCOC1,,,,val
US03932452,O=C1NCCN1.O=[N+]([O-])c1ccc(O)c(CBr)c1>>O=C1NCCN1Cc1cc([N+](=O)[O-])ccc1O,,CS(C)=O,O,Cl,[I-].[K+],val
US20090035323A1,CCOCc1nc2c(N)nc3ccccc3c2n1OCCN.O=C(CCSC(c1ccccc1)(c1ccccc1)c1ccccc1)ON1C(=O)CCC1=O>>CCOCc1nc2c(N)nc3ccccc3c2n1OCCNC(=O)CCS,,ClCCl,,CO,,val
US04711898,CI.COC(=O)c1ccc2c(c1)C(=O)CC(c1ccccc1)=N2>>COC(=O)c1ccc2c(c1)c(=O)cc(-c1ccccc1)n2C,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20080004302A1,COC(=O)C=Cc1cncc(OC)c1>>COC(=O)CCc1cncc(OC)c1,[Pd],CCO,,[H][H],,val
US04665203,CCCc1c(O)ccc(C(C)=O)c1O.CCOC(=O)CCC(C)=O>>CCCc1c(O)ccc2c1OC(C)(CCC(=O)OCC)CC2=O,,Cc1ccccc1,,C1CCNC1,,val
US05389682,NC(c1ccccc1)C(NC(=O)Nc1ccc([N+](=O)[O-])cc1)c1ccccc1.O=C=NC1CCCCC1>>O=C(Nc1ccc([N+](=O)[O-])cc1)NC(c1ccccc1)C(NC(=O)NC1CCCCC1)c1ccccc1,,ClCCl,,,,val
US20060100123A1,CC(C)=O.CCOC(=O)c1ccccn1>>CC(=O)CC(=O)c1ccccn1,,C1CCOC1,,C,C[O-].[Na+],val
US03991066,CC1=C2CCNCC2c2ccccc21.COC(=O)CBr>>COC(=O)CN1CCC2=C(C)c3ccccc3C2C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120172382A1,CC1(C)OB(c2cn[nH]c2)OC1(C)C.CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1cc(F)c(Oc2ccncc2Br)cc1F>>CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1cc(F)c(Oc2ccncc2-c2cn[nH]c2)cc1F,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20040053908A1,CCNCC.CNC(=O)Nc1ccc(Oc2ccnc3cc(OC[C@H]4CO4)c(C#N)cc23)cc1Cl>>CCN(CC)C[C@@H](O)COc1cc2nccc(Oc3ccc(NC(=O)NC)c(Cl)c3)c2cc1C#N,,C1CCOC1,,,,val
US20060020038A1,CC(C)(Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1.CCOC(=O)CI>>CCOC(=O)COc1c(C(C)(C)C)cc(SC(C)(C)Sc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1C(C)(C)C,,CCOCC,CN(C)C=O,[F-].[K+],,val
US20130190307A1,NNc1cnc2ccc(Br)cc2n1.O=C(Cl)OC(Cl)(Cl)Cl>>O=c1[nH]nc2cnc3ccc(Br)cc3n12,,ClCCl,,CCN(CC)CC,,val
US20100048539A1,Cc1ccc([N+](=O)[O-])cc1Nc1nccc(-c2cncc3ccccc23)n1>>Cc1ccc(N)cc1Nc1nccc(-c2cncc3ccccc23)n1,[Pd],CO,,[H][H],,val
US20110082138A1,CCB(CC)CC.Cc1ccc(S(=O)(=O)n2ccc3c(I)c(Br)cnc32)cc1>>CCc1c(Br)cnc2c1ccn2S(=O)(=O)c1ccc(C)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030144329A1,CC1(C)CCC(C)(C)c2cc([N+](=O)[O-])ccc21>>CC1(C)CCC(C)(C)c2cc(N)ccc21,[Pd],ClCCl,,[H][H],,val
US20010047026A1,Cl.NNc1ccccc1C(=O)O.O=C1COc2ccc(Br)cc21>>O=C(O)c1cccc2c1[nH]c1c3cc(Cl)ccc3oc21,,CCO,O,,,val
US05143920,CCCC(=O)c1cnc2c(OC)cccc2c1Cl.Cc1cc(O)ccc1N>>CCCC(=O)c1cnc2c(OC)cccc2c1Nc1ccc(O)cc1C,,C1COCCO1,,,,val
US04871872,CCOC(=O)Cl.NC(Cc1ccccc1)c1ccccc1>>CCOC(=O)NC(Cc1ccccc1)c1ccccc1,,ClCCl,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100022598A1,CC(C)(C)Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(CC(C)(O)c2ccc(-c3ccns3)cc2)n1>>CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-c3ccns3)cc2)n1,,CO,,Cl,,val
US06197737B1,CCCCOc1ccc(C(=O)Cl)cc1.O=C1CCCCCN1>>CCCCOc1ccc(C(=O)C2CCCCNC2=O)cc1,,C1COCCO1,,CCN(CC)CC,,val
US20090088430A1,COC(=O)c1ccc(-c2cc(Cl)c(C[C@@H]3CCN(C4CCN(C(=O)OC(C)(C)C)CC4)C3=O)c(Cl)c2)cc1>>CC(C)(C)OC(=O)N1CCC(N2CC[C@@H](Cc3c(Cl)cc(-c4ccc(C(=O)O)cc4)cc3Cl)C2=O)CC1,,C1CCOC1,,[Li+].[OH-],,val
US20140206618A1,C=Cc1ccc(F)c(C#N)c1F.O=C(OO)c1cccc(Cl)c1>>N#Cc1c(F)ccc(C2CO2)c1F,,ClCCl,,,,val
US20150166587A1,CCOC(=O)OCC.O=S(=O)([N-]S(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O=S(=O)([N-]S(=O)(=O)C(F)(F)F)C(F)(F)F,,CO,,N#N,,val
US20100056577A1,CN(Cc1c[nH]c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C.O=S(=O)(Cl)c1cncc(F)c1>>CN(Cc1cn(S(=O)(=O)c2cncc(F)c2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C,,C1CCOC1,O,C1COCCOCCOCCOCCO1,[H-].[Na+],val
US20120277244A1,CC(C)(C)OC(=O)NC(CN(CC#N)C(=O)OCC(Cl)(Cl)Cl)(c1ccccc1F)C(F)F>>NC1=NC(c2ccccc2F)(C(F)F)CN(C(=O)OCC(Cl)(Cl)Cl)C1,,C1COCCO1,ClCCl,Cl,,val
US20120295884A1,COC(=O)[C@@H]1C[C@H](N(C)C(=O)OCC(Cl)(Cl)Cl)CN1C(=O)OC(C)(C)C>>CN(C(=O)OCC(Cl)(Cl)Cl)[C@H]1C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C1,,CO,,[Na+].[OH-],,val
US20110070193A1,CC(C)(C)OC(=O)Nc1ccc(O)cc1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)Nc1ccc(OS(C)(=O)=O)cc1,,ClCCl,,CCN(CC)CC,,val
US20050222141A1,COC(=O)c1ccc(C(=O)O)cc1[N+](=O)[O-]>>COC(=O)c1ccc(CO)cc1[N+](=O)[O-],,CO,,C1CCOC1,Cl,val
US20070032485A1,CCOC(=O)Cl.CC[C@H]1C[C@@H](NC(=O)O[C@@H](C)c2ccccc2)c2nc(OC)ccc2N1>>CCOC(=O)N1c2ccc(OC)nc2[C@H](NC(=O)O[C@@H](C)c2ccccc2)C[C@@H]1CC,,ClCCl,,c1ccncc1,,val
US20060128702A1,Clc1nc(-c2ccccc2)nc2ccccc12.Oc1cccc(O)c1>>Oc1ccc(-c2nc(-c3ccccc3)nc3ccccc23)c(O)c1,,CC(Cl)Cl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20070010670A1,O=C(Cl)c1cc(Cl)c(OCc2ccccc2)c(Cl)c1.c1ccc2c(c1)CCCN2>>O=C(c1cc(Cl)c(OCc2ccccc2)c(Cl)c1)N1CCCc2ccccc21,,ClC(Cl)Cl,,CCN(CC)CC,,val
US05646172,CN1CCC(N)(C#N)CC1.N#Cc1ccc(N2C(=O)N(CCCC(=O)O)C3(CCOCC3)C2=O)cc1C(F)(F)F>>CN1CCC2(CC1)NC(=O)N(c1ccc(C#N)c(C(F)(F)F)c1)C2=N,,CCN(CC)CC,,ClCCCl,,val
US20070142446A1,CC(=O)C(=O)CCl.COc1cccc2c(C(N)=S)cn(CC3CCCCC3)c12>>COc1cccc2c(-c3nc(C(C)=O)cs3)cn(CC3CCCCC3)c12,,CCO,,,,val
US20120040954A1,COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCC(N(C(C)=O)C(C)C)CC4)cc3)nc2c1>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCC(NC(C)C)CC4)cc3)nc2c1,,Cl,,[Na+].[OH-],,val
US20100105714A1,CC(C)(C)OC(=O)N1CCC2(CC1)OC(c1ccncc1)=C(Br)C2=O.OB(O)c1ccc2c(c1)OCO2>>CC(C)(C)OC(=O)N1CCC2(CC1)OC(c1ccncc1)=C(c1ccc3c(c1)OCO3)C2=O,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US04381303,Cn1ncc([N+](=O)[O-])c1C(=O)Nc1cccnc1Cl>>Cn1ncc(N)c1C(=O)Nc1cccnc1Cl,[Pd],C1COCCO1,,,,val
US20110312905A1,O=[N+]([O-])c1ccc(S(=O)(=O)Cl)c([N+](=O)[O-])c1.[O-][n+]1ccccc1O>>O=c1ccccn1OS(=O)(=O)c1ccc([N+](=O)[O-])cc1[N+](=O)[O-],,c1ccncc1,,,,val
US20090069577A1,C1=COCCC1.OCc1ccccc1Br>>Brc1ccccc1COC1CCCCO1,Cl,CCOCC,,O=C([O-])O.[Na+],,val
US20140024576A1,OC[C@@H](O)[C@H]1O[C@H](Sc2ccccc2)[C@@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1>>OC[C@@H](O)[C@H]1OC[C@@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1,,CCO,,,,val
US04443443,C=CCN1CCN(CCCN2C(=O)c3ccccc3C2=O)CC1>>C=CCN1CCN(CCCN)CC1,,CCO,,NN,O,val
US20090176836A1,O=C1OCCC1(Cc1ccccc1)N=C(c1ccccc1)c1ccccc1>>NC1(Cc2ccccc2)CCOC1=O,,C1CCOC1,CO,Cl,,val
US20060128715A1,CON(C(C)=O)C(C)=O.Cc1ncc2c(n1)CCC(NCC(O)C(N)Cc1cc(F)cc(F)c1)(c1cccc(C(C)(C)C)c1)C2>>CC(=O)NC(Cc1cc(F)cc(F)c1)C(O)CNC1(c2cccc(C(C)(C)C)c2)CCc2nc(C)ncc2C1,,ClCCl,,,,val
US20140206673A1,CC1(C)CC(=O)C(C(=O)C2CC2)CO1.N#CCC(N)=O>>CC1(C)Cc2c(C#N)c(O)nc(C3CC3)c2CO1,,CCO,,CCNCC,,val
US06262040B1,CCc1nn(C2CCCC2)c2cc(Br)ccc12.OB(O)c1cccs1>>CCc1nn(C2CCCC2)c2cc(-c3cccs3)ccc12,,CCOC(C)=O,CO,O=C([O-])[O-].[Na+].[Na+],,val
US20080214833A1,COc1ccccc1OCCN.O=C(O)C(=O)O.c1ccc2c(c1)[nH]c1cccc(OCC3CO3)c12>>COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12.O=C([O-])C(=O)[O-],,CC(C)O,,,,val
US04910218,CC(=O)O.COCC(CO)(COC)NCc1ccccc1>>COCC(N)(COC)COC(C)=O,[Pd],CCO,,,,val
US20120101127A1,Cc1ccc2c(c1)C(C)(C)CC(c1cccc(N)c1)N2.O=S(=O)(Cl)c1ccc(F)cc1>>Cc1ccc2c(c1)C(C)(C)CC(c1cccc(NS(=O)(=O)c3ccc(F)cc3)c1)N2,,ClCCl,,c1ccncc1,,val
US20150236274A1,Fc1cccc(Br)c1.Oc1ccccc1>>Brc1cccc(Oc2ccccc2)c1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20070120112A1,Nc1cccc(N)c1N.O=C1C(=O)c2ccccc2-c2ccccc21>>Nc1cccc2nc3c4ccccc4c4ccccc4c3nc12,,CO,,CC(=O)O,,val
US20150266819A1,Fc1ccc(CCCl)cc1.SCc1ccc(Cl)cc1>>Fc1ccc(CCSCc2ccc(Cl)cc2)cc1,,CO,,[Na+].[OH-],,val
US20100273806A1,CCN(CC)c1cc(C(F)(F)F)cc(C(=O)O)n1.O=C(Cl)C(=O)Cl>>CCN(CC)c1cc(C(F)(F)F)cc(C(=O)Cl)n1,CN(C)C=O,ClCCl,,,,val
US20080207720A1,CCOC(=O)c1ccc(CC(=N)SCc2ccccc2)o1.N#CC(N)C(N)=O>>CCOC(=O)c1ccc(Cc2nc(C(N)=O)c(N)[nH]2)o1,,CO,,O=C([O-])O.[Na+],,val
US06589967B1,CC(=NO)c1cc(C)cc(C)n1.COc1cccc(F)c1CCl>>COc1cccc(F)c1CON=C(C)c1cc(C)cc(C)n1,,CN(C)C=O,,[H-].[Na+],,val
US20080197325A1,O=C1OC(=O)c2cc(-c3ccc4c(c3)C(=O)OC4=O)ccc21>>OCc1ccc(-c2ccc(CO)c(CO)c2)cc1CO,,C1COCCO1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090137572A1,CC(C)NC(=O)CN1CCN(c2ccc(NC(=N)N)cc2)CC1.Cc1nc(C)c(/C=C/C(=O)N(C)C)s1>>Cc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(CC(=O)NC(C)C)CC4)cc3)n2)s1,,CC#N,,,,val
US20080280917A1,COc1ccc2c(Cl)ccnc2c1.O=c1ccc(Br)cn1CCO>>COc1ccc2c(OCCn3cc(Br)ccc3=O)ccnc2c1,,CN(C)C=O,,[H-].[Na+],,val
US20060270857A1,COC(=O)[C@]1(C)CSC(C)=N1>>CC1=N[C@](C)(C(=O)O)CS1,,CCO,,CC(=O)O,[Na+].[OH-],val
US03954892,O=[N+]([O-])O.Oc1ccccc1>>O=[N+]([O-])c1ccc(O)cc1,,c1ccccc1,,,,val
US20060040925A1,CC1(C)OC(=O)CC(=O)O1.COC(OC)OC.Nc1ccc(F)cc1>>CC1(C)OC(=O)C(=CNc2ccc(F)cc2)C(=O)O1,,CCO,,,,val
US20090149456A1,CN1CCc2ccc(N)cc2C1.COc1ccc(-c2nn3ccccc3c2-c2ccnc(Cl)n2)cc1NC(=O)Cc1cccs1>>COc1ccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc4c(c3)CN(C)CC4)n2)cc1NC(=O)Cc1cccs1,,CC(C)O,,Cl,,val
US20030013733A1,Cc1ccc(S(=O)(=O)CCCC2CCCCN2C(C#N)c2ccc(Br)cc2)cc1>>N#CC1(c2ccc(Br)cc2)CCCC2CCCCN21,,CN(C)C=O,,O,[H-].[Na+],val
US20050065118A1,OC(c1cccc(C2OCCO2)c1)c1cccc(C(F)(F)F)c1>>O=Cc1cccc(C(O)c2cccc(C(F)(F)F)c2)c1,,CC(C)=O,O,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US05571813,CCc1cc(Cl)n2nccc2n1.NC(N)=S>>CCc1cc(S)n2nccc2n1,,CCO,,,,val
US20100331293A1,C1COCCN1.Cc1c(-c2ccccn2)nc2c(F)ccc(F)c2c1Nc1cc(Br)cnc1N1CCOCC1>>Cc1c(-c2ccccn2)nc2c(F)ccc(F)c2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1,,Cc1ccccc1,,,,val
US20010041300A1,C#Cc1ccc(O)cc1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.c1ccncc1>>C=Cc1ccc(O)cc1.C=Cc1ccc(OC(=O)OC(C)(C)C)cc1,,c1ccncc1,,Cl,O,val
US20080146531A1,C1=COCCC1.CCCCCC(O)Br>>BrCCCCCCOC1CCCCO1,,COC(C)(C)C,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20160264554A1,CNC.Nc1ccc(C(=O)N[C@@H]2C[C@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC(F)(F)C2)cc1.O=C(Cl)/C=C/CBr>>CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N[C@@H]2C[C@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC(F)(F)C2)cc1,,C1CCOC1,CN1CCCC1=O,CCN(C(C)C)C(C)C,ClCCl,val
US20090076074A1,CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(C(=O)OC)cc34)cc2)cn1>>CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(C(=O)O)cc34)cc2)cn1,,CO,,Cl,[Li+].[OH-],val
US20130225561A1,CC(C)(C)OC(=O)N1CCN(C2CCc3ccc(N4C(=O)c5ccccc5C4=O)cc3C2)CC1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C1c2ccccc2C(=O)N1c1ccc2c(c1)CC(N1CCN(C(=O)C(F)(F)F)CC1)CC2,,c1ccncc1,,O=C(O)C(F)(F)F,,val
US20040214817A1,CC(C)(C)OC(=O)NN.Ic1cccc(N2CCOCC2)c1>>CC(C)(C)OC(=O)N(N)c1cccc(N2CCOCC2)c1,[Cu]I,CN(C)C=O,O,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US20090023702A1,CCc1cnc(N2CCC(Oc3cc[nH]c(=O)c3)CC2)nc1.CS(=O)(=O)c1ccc(F)c(F)c1>>CCc1cnc(N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)cc4F)c(=O)c3)CC2)nc1,,CN(C)C=O,,[H-].[Na+],,val
US20160143870A1,CC(C)CN(CC(C)C)c1ccc(Br)cc1N.Cc1ccc(CC(=O)O)cc1>>Cc1ccc(CC(=O)Nc2cc(Br)ccc2N(CC(C)C)CC(C)C)cc1,,CCOCC,CN(C)C=O,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20110166121A1,CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(C(=O)O)nc2s1.OC1CCNC1>>CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(C(=O)N3CCC(O)C3)nc2s1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110092505A1,COC(=O)c1cc(Cl)nc(N2CCNC(C)(C)C2)c1.C[Sn](C)(C)c1ccnc(NC2CCCCC2)c1>>COC(=O)c1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCNC(C)(C)C2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,,N#N,,val
US20160159718A1,CC(C)(C)c1cc(C(C)(C)C)c2op(Cl)oc3c(C(C)(C)C)cc(C(C)(C)C)cc3c2c1.Oc1c2ccccc2cc2ccccc12>>CC(C)(C)c1cc(C(C)(C)C)c2op(Oc3c4ccccc4cc4ccccc34)oc3c(C(C)(C)C)cc(C(C)(C)C)cc3c2c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20140088117A1,CC(C)OB1OC(C)(C)C(C)(C)O1.CC(O)c1cc(F)cc(F)c1>>CC(O)c1cc(F)c(B2OC(C)(C)C(C)(C)O2)c(F)c1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20130102791A1,C1CCC2OC2C1.NCc1ccccc1>>O[C@@H]1CCCC[C@H]1NCc1ccccc1,,O,,,,val
US20130060041A1,CCNC(=S)N1CC(CC)C=N1.CI>>CCN=C(SC)N1CC(CC)C=N1,,CO,,,,val
US20050020838A1,BrCCBr.Cc1cc(I)ccc1O>>Cc1cc(I)ccc1OCCBr,,ClCCl,,CCO,[Na+].[OH-],val
US05284847,CC(C)(C)OC(=O)Nc1scc(C#N)c1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.CCOC(=O)C(=O)OCC>>N#Cc1csc2[nH]c(=O)c(=O)[nH]c12,,CC(=O)O,,,,val
US20150031679A1,N#CCCc1ccccc1Br>>NCCCc1ccccc1Br,,C1CCOC1,,B,,val
US05037829,CC(=O)Nc1ccc(C(c2ccccc2)n2ccnc2)cc1C=O.N>>Cc1ncc2cc(C(c3ccccc3)n3ccnc3)ccc2n1,,CO,,,,val
US20150344919A1,CC(C)CC(C#N)CC#N.O=C([O-])O>>CC(C)CC(C#N)CC(=O)O,,O,,Cl,,val
US04424213,CNc1ccc(C(=O)O)cc1>>CNC1CCC(C(=O)O)CC1,[Rh],O,,[H][H],,val
US20150175557A1,CC1(C)C[C@H](Nc2nc(S(C)(=O)=O)ncc2C#N)CC[C@@H]1O.NCCc1cc(Cl)c[n+]([O-])c1>>CC1(C)C[C@H](Nc2nc(NCCc3cc(Cl)c[n+]([O-])c3)ncc2C#N)CC[C@@H]1O,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20100317651A1,CCCN(C)c1cnc(C=O)c(Cl)n1.OCCNCc1ccccc1>>CCCN(C)c1cnc(CN(CCO)Cc2ccccc2)c(Cl)n1,,CC#N,CC(=O)O,O=C([O-])O.[Na+],,val
US20080207654A1,CCCc1nc(C)n(-c2ccc(OC(C)(C)CO)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCc1nc(C)n(-c2ccc(OC(C)(C)CO)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20060100436A1,O=C(Cl)C(=O)Cl.O=C(O)c1cc(Br)c(F)c(Cl)c1F>>O=C(Cl)c1cc(Br)c(F)c(Cl)c1F,CN(C)C=O,ClCCl,,,,val
US06136852,CCOC(=O)CCCCc1ccc2c(c1)C[C@@H](NC(=O)OC(C)(C)C)CC2>>CCOC(=O)CCCCc1ccc2c(c1)C[C@@H](N)CC2,,CCO,,Cl,,val
US20110288076A1,O=C(Cc1c[nH]cn1)N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ncc(Br)s2)cc1>>O=C(Cc1c[nH]cn1)N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2nccs2)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US20130018034A1,Brc1ccnc2[nH]ccc12.CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(B3OC(C)(C)C(C)(C)O3)cn2)C1>>CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(-c3ccnc4[nH]ccc34)cn2)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20130324528A1,CS(=O)(=O)Cl.Cc1ccc(F)c(-c2cc(Nc3ccnc4cn(C5CCNCC5)nc34)ccn2)c1>>Cc1ccc(F)c(-c2cc(Nc3ccnc4cn(C5CCN(S(C)(=O)=O)CC5)nc34)ccn2)c1,,ClCCl,,CCN(CC)CC,,val
US20080234237A1,CN1CCC(N2C(=O)CCc3ccccc32)CC1.O=[N+]([O-])O>>CN1CCC(N2C(=O)CCc3cc([N+](=O)[O-])ccc32)CC1,,O=S(=O)(O)O,,,,val
US20150148332A1,Cc1nc(C)c2nc(/C=C/c3nc(N4CCCC4)nn3C)nn2c1C>>Cc1nc(C)c2nc(CCc3nc(N4CCCC4)nn3C)nn2c1C,[Pd],CC(=O)O,,,,val
US20120202856A1,CCOC(=O)c1c(C(F)(F)F)c(C(C)(C)C)nn1C>>Cn1nc(C(C)(C)C)c(C(F)(F)F)c1C(=O)O,,C1CCOC1,CO,[Na+].[OH-],,val
US20070161653A1,C#CC(=O)c1c(-c2ccco2)nn2c(Cl)cccc12.N=C(N)NC1CCCC1>>Clc1cccc2c(-c3ccnc(NC4CCCC4)n3)c(-c3ccco3)nn12,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100234285A1,CNC.O=C(Cl)c1ncc(Br)cn1>>CN(C)C(=O)c1ncc(Br)cn1,,C1CCOC1,CCOC(C)=O,,,val
US20040044052A1,COC(=O)[C@H]1CN(c2cc(F)c3c(c2)oc(=O)n3C)C(=O)O1.N>>Cn1c(=O)oc2cc(N3C[C@H](C(N)=O)OC3=O)cc(F)c21,,CO,,,,val
US20040236084A1,CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3ncc(C#N)c(NC4CCCC4)n3)nc2)CC1>>N#Cc1cnc(Nc2ccc(N3CCNCC3)cn2)nc1NC1CCCC1,,CCOC(C)=O,,Cl,,val
US20120059017A1,COC(=O)C(C1CCN(C(=O)OC(C)(C)C)CC1)C(O)c1ccccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)N1CCC(C2C(=O)Nc3ccccc3C2O)CC1,[Fe],CCOC(C)=O,,CC(=O)O,,val
US04300942,CCN(CC)CC.CCOC(=O)CN(CP(=O)(Cl)Cl)C(=O)SCc1ccccc1.CCOCC.Cc1cccc(O)c1>>CCOC(=O)CN(CP(=O)(Oc1cccc(C)c1)Oc1cccc(C)c1)C(=O)SCc1ccccc1,,CCOCC,,,,val
US04117167,Nc1cc(Cl)ccc1Cl.O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(C(F)(F)F)c1>>O=[N+]([O-])c1cc([N+](=O)[O-])c(Nc2cc(Cl)ccc2Cl)c(C(F)(F)F)c1,,CN(C)C=O,O,Cl,[K+].[OH-],val
US20160009691A1,CCOc1ncc(CCl)cc1Br.Cc1nn[nH]n1>>CCOc1ncc(Cn2nnnc2C)cc1Br,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20120157428A1,CON(C)C(=O)c1csc(C)c1C.Clc1ccc([Mg]Br)cc1>>Cc1scc(C(=O)c2ccc(Cl)cc2)c1C,,C1CCOC1,CCOCC,Cl,,val
US20070149533A1,CNC(=O)c1cc(Oc2ccc3c(c2)CC(C(=O)Nc2cc(CN)cc(C(F)(F)F)c2)CC3)ccn1.OCCBr>>CNC(=O)c1cc(Oc2ccc3c(c2)CC(C(=O)Nc2cc(CNCCO)cc(C(F)(F)F)c2)CC3)ccn1,,CN(C)C=O,O,,,val
US20100261679A1,O=[N+]([O-])c1ccccc1F.OCCO>>O=[N+]([O-])c1ccccc1OCCO,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110160198A1,BrP(Br)Br.Cc1c[n+]([O-])c(C)cc1[N+](=O)[O-]>>Cc1cc(Br)c(C)cn1,,CCOC(C)=O,,[Na+].[OH-],,val
US20110160198A1,Cc1nc(C(=O)O)co1.O=C(Cl)C(=O)Cl>>Cc1nc(C(=O)Cl)co1,,ClCCl,,,,val
US04398029,CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)c(F)c21.OCCBr>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(CCO)CC3)c(F)c21,,CN(C)C=O,,CCN(CC)CC,Cl,val
US03959322,C=CCBr.CC[C@]12CC[C@@H]3c4ccc(OC)cc4CC[C@H]3[C@@H]1CC[C@@H]2O>>C=C(C)OC1CC[C@H]2[C@@H]3CCc4cc(OC)ccc4[C@H]3CC[C@]12CC,,Cc1ccccc1C,,Cl,[H-].[Na+],val
US20050148572A1,COC(=O)[C@H](CC(C)C)N[C@@H](C(=O)Nc1ccccc1OCc1ccccc1)c1ccc2occc2c1>>COC(=O)[C@H](CC(C)C)N[C@@H](C(=O)Nc1ccccc1O)c1ccc2occc2c1,[Pd],CCOC(C)=O,,,,val
US05057524,CCOC(=O)CCCCCCCBr.OC(c1ccc(F)cc1)(c1ccc(F)cc1)C1CCNCC1>>CCOC(=O)CCCCCCCN1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1,,CN(C)C=O,,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20090186870A1,CN1CCNCC1.CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4ccnn4)ccc3Cl)sc2c1.NC(=O)c1cc(-c2ccccn2)ccc1Cl>>CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-c5ccccn5)ccc4Cl)sc3c2)CC1,,C1CCOC1,,O=C(Cl)C(=O)Cl,,val
US20140179715A1,CN1CCn2c1cc(Cl)nc2=O.N#Cc1ccc(Oc2ccc(CO)cc2C#N)cc1F>>CN1CCn2c1cc(OCc1ccc(Oc3ccc(C#N)c(F)c3)c(C#N)c1)nc2=O,,C1CCOC1,,[H-].[Na+],,val
US20070004725A1,CN(C)C(=O)C(NC(=O)OC(C)(C)C)c1ccc(Oc2ccc(CCC(=O)O)cc2)cc1>>CN(C)C(=O)C(N)c1ccc(Oc2ccc(CCC(=O)O)cc2)cc1,,ClCCl,,,,val
US06329380B1,[N-]=[N+]=NCC1CCCN(C(=O)OCc2ccccc2)C1>>NCC1CCCN(C(=O)OCc2ccccc2)C1,,C1CCOC1,Cl,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060293394A1,COc1cc(Br)cc(OC)c1OC.COc1ccc2c(c1)CCCCC2=O>>COc1ccc2c(c1)CCCCC2(O)c1cc(OC)c(OC)c(OC)c1,,CCOCC,,O,[Li]CCCC,val
US04966900,COC(=O)c1ccc(O)c(O)c1.NN>>NNC(=O)c1ccc(O)c(O)c1,,O,,CO,,val
US04730008,ClCCOCCCl.Nc1ccc(CCCCO)cc1>>OCCCCc1ccc(N2CCOCC2)cc1,,CN(C)C=O,,[I-].[K+],,val
US20060276465A1,CC1(C)CC=C(OS(=O)(=O)C(F)(F)F)CC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC1(C)CC=C(B2OC(C)(C)C(C)(C)O2)CC1,,C1COCCO1,,CC(=O)[O-].[K+],,val
US04960758,CN(C)C(=S)Cl.N#Cc1ccc(C(=O)c2ccccc2O)cc1>>CN(C)C(=S)Oc1ccccc1C(=O)c1ccc(C#N)cc1,,CC(C)=O,O,[K+].[OH-],,val
US20090181942A1,CC(=O)O.COC1CCC(OC)O1.Nc1ccc(Cl)cc1Br>>Clc1ccc(-n2cccc2)c(Br)c1,,CC(=O)O,,,,val
US05958821,C1=CCCCCCC1.CC#N.O=C1c2ccccc2C(=O)N1O>>O=C1C=CCCCCC1.OC1C=CCCCCC1,,CC#N,,O=O,,val
US20130338152A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Fc1c(Br)cccc1OC[C@@H]1CCCO1>>CC1(C)OB(c2cccc(OC[C@@H]3CCCO3)c2F)OC1(C)C,,CN(C)C=O,,CC(=O)[O-].[K+],,val
US04607006,COc1ccc(C2=NN(c3ccccc3)C(c3ccc([N+](=O)[O-])cc3)C2)cc1>>COc1ccc(C2=NN(c3ccccc3)C(c3ccc(N)cc3)C2)cc1,[Fe],CC(=O)O,,O,[Cl-].[NH4+],val
US05053409,CCCc1ccc(N)cc1.[N-]=C=O>>CCCc1ccc(NC(N)=O)cc1,,CC(=O)O,,O,,val
US20030078261A1,CCCCc1ccc(CN(CCCCCCC(=O)OC)S(=O)(=O)c2cccnc2)cc1>>CCCCc1ccc(CN(CCCCCCC(=O)O)S(=O)(=O)c2cccnc2)cc1,,CO,,[Na+].[OH-],,val
US20070112034A1,O=C(Cn1cnc2ccccc21)Nc1ccc(Br)cc1.OB(O)c1ccccc1Cl>>O=C(Cn1cnc2ccccc21)Nc1ccc(-c2ccccc2Cl)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,CCO,O=C([O-])[O-].[K+].[K+],val
US20150299203A1,Clc1cc(Cl)n2ncc(Br)c2n1.NCC1CCOCC1>>Clc1cc(NCC2CCOCC2)n2ncc(Br)c2n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060223805A1,NCc1ccc(-c2ccccc2)cc1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.OCC(F)(F)F>>O=C(NCc1ccc(-c2ccccc2)cc1)OCC(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150368228A1,O=[N+]([O-])c1cc(Cl)c(-n2cccn2)c(Cl)c1>>Nc1cc(Cl)c(-n2cccn2)c(Cl)c1,[Fe],O,,CO,[Cl-].[NH4+],val
US20040157885A1,CCOC(=O)c1cc([C@H]2CCCN(C(=O)OCc3ccc(C(F)(F)F)cc3)C2)ccc1C>>Cc1ccc([C@H]2CCCN(C(=O)OCc3ccc(C(F)(F)F)cc3)C2)cc1C(=O)O,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US20070249597A1,CC#N.COC(=O)C1CCN(C(=O)OCc2ccccc2)C1>>N#CCC(=O)C1CCN(C(=O)OCc2ccccc2)C1,,C1CCOC1,O,Cl,[Li]CCCC,val
US20130345120A1,CCc1cccc(NC(=O)C2CC=NN2C(=O)[C@@H](CC(=O)OC(C)(C)C)CC2CCCC2)n1>>CCc1cccc(NC(=O)C2CC=NN2C(=O)[C@@H](CC(=O)O)CC2CCCC2)n1,,C1COCCO1,,Cl,,val
US20110237584A1,Clc1nc2ccccc2nc1Cl.NS(=O)(=O)c1cccc(Cl)c1Cl>>O=S(=O)(Nc1nc2ccccc2nc1Cl)c1cccc(Cl)c1Cl,,CS(C)=O,,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US20050131014A1,CCOC(=O)Cc1ccc(CBr)cc1.Oc1cccc(-c2c(-c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1>>CCOC(=O)Cc1ccc(COc2cccc(-c3nc4c(C(F)(F)F)cccc4cc3-c3ccccc3)c2)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100292208A1,CC(=O)NC1CCNCC1.CC(=O)Oc1ccc2c(CCl)coc2c1>>CC(=O)NC1CCN(Cc2coc3cc(O)ccc23)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100216760A1,CC(C)Cn1cc(C(C)(C)C)s/c1=N\C(=O)c1cc(C(F)(F)F)ccc1OC[C@@H]1CCN1C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)O)cc1>>CC(C)Cn1cc(C(C)(C)C)s/c1=N\C(=O)c1cc(C(F)(F)F)ccc1OC[C@@H]1CCN1.Cc1ccc(S(=O)(=O)O)cc1,,CCOC(C)=O,ClCCl,O,O=C(O)C(F)(F)F,val
US20070010558A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(C(N)=O)cn2)CC1.Cl>>Cl.NC(=O)c1ccc(OC2CCNCC2)nc1,,C1CCOC1,,,,val
US20090048251A1,CC(=O)NCCO.Fc1cccc2ncnc(Nc3ccc4c(cnn4Cc4ccccn4)c3)c12>>Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4ccccn4)c3)c12,,CC(=O)N(C)C,,[H-].[Na+],,val
US20070027178A1,Cl.Nc1cc(Cl)ccc1Sc1ccc(Cl)cc1.O=N[O-]>>Cl.NNc1cc(Cl)ccc1Sc1ccc(Cl)cc1,,O,,Cl[Sn]Cl,,val
US20020151554A1,CC(C)N1CCN(c2ccc(N)cc2)CC1.S=C(n1ccnc1)n1ccnc1>>CC(C)N1CCN(c2ccc(N=C=S)cc2)CC1,,CN(C)C=O,,,,val
US20160058894A1,ClCc1nc2ccccc2o1.Oc1ccc(-c2nn(CCF)cc2-c2ccncc2)cc1>>FCCn1cc(-c2ccncc2)c(-c2ccc(OCc3nc4ccccc4o3)cc2)n1,,C1CCOC1,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05789440,CC(C)CCC1(c2ccccc2)CC(O)=CC(=O)O1.Cc1ccc(S(=O)(O)=S)cc1.Cc1ccccc1-c1ccccc1>>CC(C)CCC1(c2ccccc2)CC(O)=C(SCc2ccccc2-c2ccccc2)C(=O)O1,,CCO,CCOCC,CCN(CC)CC,O=C([O-])O.[Na+],val
US20160031899A1,CC(C)(C)C(=O)OC[C@H]1C[C@@H](OC(=O)C(C)(C)C)CC[C@]1(C)[C@H]1CC[C@]2(C)c3ncccc3C[C@H]2[C@@H]1CO.CS(=O)(=O)Cl>>CC(C)(C)C(=O)OC[C@H]1C[C@@H](OC(=O)C(C)(C)C)CC[C@]1(C)[C@H]1CC[C@]2(C)c3ncccc3C[C@H]2[C@@H]1COS(C)(=O)=O,,ClCCl,,,,val
US20070197570A1,CC(C)(C)OC(=O)N1CCC(O)CC1.CC(C)(C)[Si](C)(C)OCCBr>>CC(C)(C)OC(=O)N1CCC(OCCO[Si](C)(C)C(C)(C)C)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US20070123535A1,CC(C)(C)[Si](C)(C)Cl.Clc1ccnc2[nH]ccc12>>CC(C)(C)[Si](C)(C)n1ccc2c(Cl)ccnc21,,C1CCOC1,,[Li]CCCC,,val
US20090176847A1,CC(=O)OC1CC2CC(NCC(=O)N3CCCC3C#N)CC2C1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(=O)OC1CC2CC(N(CC(=O)N3CCCC3C#N)C(=O)OC(C)(C)C)CC2C1,,ClCCl,,O,O=C([O-])[O-].[K+].[K+],val
US20100297113A1,CCOC(=O)/C(C)=C/c1c(SC)c(OC)c2ccccc2c1OC.COc1cc(/C=C(\C)C(=O)O)c(OC)c2ccccc12>>COc1c(/C=C(\C)C(=O)O)c(SC)c(OC)c2ccccc12,,CCOC(C)=O,,,,val
US20160122364A1,Brc1cnc2c(Br)snc2c1.C1CCNC1>>Brc1cnc2c(N3CCCC3)snc2c1,,CCO,,,,val
US04309426,CNC(=S)NN.O=C(CCl)c1ccc(Cl)cc1Cl>>CNC1=NN=C(c2ccc(Cl)cc2Cl)CS1.Cl,,CO,,,,val
US20150252032A1,Cc1cccc(C=O)c1C.NO>>Cc1cccc(C=NO)c1C,,CO,,Cl,CC(=O)[O-].[Na+],val
US05411980,CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1.O=C(Cl)N1CCOCC1>>CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)N2CCOCC2)cc1,,C1CCOC1,,[H-].[Na+],,val
US20040067935A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCCc1ccc(C(F)(F)F)cc1>>Cc1ccc(S(=O)(=O)OCCc2ccc(C(F)(F)F)cc2)cc1,,c1ccncc1,,,,val
US05859009,CCC(CC)(CO)CO.O=C1CCC(=O)CC1>>CCC1(CC)COC2(CCC(=O)CC2)OC1,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,O,,val
US20120295915A1,Nc1cnccc1NCC1CCN(C(=O)C2CC2)C1.O=Cc1ccc(-c2ccc3[nH]ncc3c2)cc1>>O=C(C1CC1)N1CCC(Cn2c(-c3ccc(-c4ccc5[nH]ncc5c4)cc3)nc3cnccc32)C1,,CCCCO,,,,val
US06689909B1,CCS(=O)(=O)c1ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c(Cl)c1SC.O=C(OO)c1cccc(Cl)c1>>CCS(=O)(=O)c1ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c(Cl)c1S(C)=O,,ClCCl,,O=C([O-])O.[Na+],,val
US20100292206A1,CS(=O)(=O)Cl.O=C(c1ccccc1)N1CC(O)C1>>CS(=O)(=O)OC1CN(C(=O)c2ccccc2)C1,,C1CCOC1,,CCN(CC)CC,,val
US06096930,CCCC(=O)OC(=O)CCC.CN(C)c1ccccn1.Cc1c(C)c(C2CC(=O)CC(=O)C2)c(C)c2c1CC(C)(C)C2>>C=CCON=C(CC)C1=C(O)CC(c2c(C)c(C)c3c(c2C)CC(C)(C)C3)CC1=O,,Cc1ccccc1,,,,val
US05539112,CC(C)(C)C(=O)Nc1ccc(-c2cc(=O)c3c(NCCCO)c(F)cc(F)c3o2)cc1F.CS(=O)(=O)Cl>>CC(C)(C)C(=O)Nc1ccc(-c2cc(=O)c3c(NCCCOS(C)(=O)=O)c(F)cc(F)c3o2)cc1F,,c1ccncc1,,O,,val
US20130096138A1,CC(C)(C)c1ccc(CN)cc1.Nc1cccc2c(O)cccc12.O=C(Cl)Cl>>CC(C)(C)c1ccc(CNC(=O)Nc2cccc3c(O)cccc23)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20090239810A1,O=C(NCC(=O)N1CCC(Nc2ccccc2Cl)CC1)c1cc(-c2ccccc2OCc2ccccc2)[nH]n1>>O=C(NCC(=O)N1CCC(Nc2ccccc2Cl)CC1)c1cc(-c2ccccc2O)[nH]n1,[Pd],CO,,,,val
US20150232481A1,C#CCO.C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OCC)c(C)nc3cc(CN=[N+]=[N-])nn23)CC1>>C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OCC)c(C)nc3cc(Cn4cc(CO)nn4)nn23)CC1,[Cu]I,C1CCOC1,CCOCC,CCN(C(C)C)C(C)C,,val
US06610717B2,C/C(N)=C/C(=O)OCCC#N.O=C(COCCC1CCCCC1)CC(=O)OCc1ccccc1.O=Cc1cccc(Cl)c1>>CC1=C(C(=O)OCCC#N)C(c2cccc(Cl)c2)C(C(=O)OCc2ccccc2)=C(COCCC2CCCCC2)N1,,CC(C)O,,,,val
US20120309728A1,CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@H](O)C[C@]12C>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3[C@H](O)C[C@]12C,[Pd],C1COCCO1,,c1ccncc1,,val
US06136825,NCC1CCN(C[C@H]2COc3ccc(Cl)cc3O2)CC1.O=S(=O)(Cl)c1ccc(F)cc1>>O=S(=O)(NCC1CCN(C[C@H]2COc3ccc(Cl)cc3O2)CC1)c1ccc(F)cc1,,ClCCl,,CCN(CC)CC,,val
US20040110802A1,CC(=O)Cl.CC(C)(C)OC(=O)c1cc(C#N)ccc1NC(=O)c1noc2ccc(N)cc12>>CC(=O)Nc1ccc2onc(C(=O)Nc3ccc(C#N)cc3C(=O)O)c2c1,,ClC(Cl)Cl,,c1ccncc1,,val
US20130096113A1,CSc1nc2ccc(C=O)cc2s1.Nc1ccc(Br)cc1[N+](=O)[O-]>>CSc1nc2ccc(CNc3ccc(Br)cc3[N+](=O)[O-])cc2s1,,ClCCl,O=C(O)C(F)(F)F,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120001123A1,CCCc1ccc(-c2cc(F)c(B(O)O)c(F)c2)cc1.Cc1ccc(Br)s1>>CCCc1ccc(-c2cc(F)c(-c3ccc(C)s3)c(F)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20150133422A1,CC(C)(C)OC(=O)N1CCC(n2cc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)cn2)CC1.Cl>>Cl.O=S(=O)(c1ccccc1)n1cc(-c2cnn(C3CCNCC3)c2)c2ccc(F)cc21,,C1COCCO1,,,,val
US04737313,CCCCCCCCO.O=Cc1ccc(C(=O)Cl)cc1>>CCCCCCCCOC(=O)c1ccc(C=O)cc1,,Cc1ccccc1,c1ccncc1,Cl,,val
US20050288398A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)Oc1ccc(C[C@H](N)C(=O)O)cc1O[Si](C)(C)C(C)(C)C>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O[Si](C)(C)C(C)(C)C)c(O[Si](C)(C)C(C)(C)C)c1)C(=O)O,,C1CCOC1,,O,O=C([O-])O.[Na+],val
US04309559,CCCS(=O)(=O)Cl.Cc1cccc(C)c1N>>CCCS(=O)(=O)Nc1c(C)cccc1C,,Cc1ccccc1,,,,val
US20150342185A1,CI.Cc1cc(Br)cc(C)c1C1C(=O)CC(CC2CCOCC2)CC1=O>>COC1=C(c2c(C)cc(Br)cc2C)C(=O)CC(CC2CCOCC2)C1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080096861A1,CC(C)(C)OC(=O)N1CCC(CCl)CC1.CC(C)(C)OC(=O)N1CCC(CO)C1>>CC(C)(C)OC(=O)N1CCC(CCl)C1,,ClC(Cl)(Cl)Cl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04994486,CCOC(=O)CC(Cc1ccccc1OC)c1ccccc1>>COc1ccccc1CC(CC(=O)O)c1ccccc1,,CO,,[Na+].[OH-],,val
US05292766,CCCN(CCC)C1Cc2c(C#N)ccc3c2C(C1)CN3C(=O)c1ccccc1>>CCCN(CCC)[C@@H]1Cc2c(C#N)ccc3c2[C@H](CN3)C1,,C1CCOC1,CCCCCC,Cl,[Li]CCCC,val
US20080207654A1,CCCc1nc(C)c(Oc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCc1nc(C)c(Oc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20030176405A1,COc1ccc2c(c1)CC[C@]1(C)C2=CC[C@@]2(C)[C@H]1CC[C@@H]2O>>COc1ccc2c(c1)CC[C@@]1(C)[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@H]21,[Pd],CO,,C1CCOC1,,val
US20100120798A1,Clc1ncnc2[nH]ccc12.NCC1(C(=O)NCc2cc(Br)no2)CCNCC1>>NCC1(C(=O)NCc2cc(Br)no2)CCN(c2ncnc3[nH]ccc23)CC1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20110112077A1,CC(C)(C)OC(=O)N1CCN(c2ccc3oc(C(N)=O)cc3c2)CC1>>CC(C)(C)OC(=O)N1CCN(c2ccc3oc(C#N)cc3c2)CC1,,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20160009644A1,c1ccc(C(SCCN2CCNCC2)c2ccccc2)cc1.c1ccc(CC2CO2)cc1>>OC(Cc1ccccc1)CN1CCN(CCSC(c2ccccc2)c2ccccc2)CC1,,CC(C)O,,,,val
US20090209532A1,O=C(c1sc2cc(O)c(O)cc2c1Cl)N1CCOCC1.O=[N+]([O-])O>>O=C(c1sc2c([N+](=O)[O-])c(O)c(O)cc2c1Cl)N1CCOCC1,,CCOC(C)=O,ClCCl,,,val
US05569664,Cc1ccc(-n2cnn(C)c2=O)cc1.O=C1CCC(=O)N1Br>>Cn1ncn(-c2ccc(CBr)cc2)c1=O,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20110257151A1,CCOC(=O)c1ccc(N)cc1.O=Cc1cccc(Br)c1>>CCOC(=O)c1ccc(N=Cc2cccc(Br)c2)cc1,,CCO,,,,val
US20130143907A1,CC(C)(C)OC(=O)NNC1COCC1O.Cl>>Cl.NNC1COCC1O,,CO,,C1COCCO1,,val
US20140206680A1,CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1nc(Cl)c2c(c1F)CN(C(=O)OC(C)(C)C)C2=O.CCCC[Sn](CCCC)(CCCC)c1ccns1>>CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1nc(-c2ccns2)c2c(c1F)CN(C(=O)OC(C)(C)C)C2=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O,,val
US20120101110A1,Cc1cnc(-c2cccc(C(=O)O)c2)o1>>Cc1cnc(-c2cccc(CO)c2)o1,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US04337198,COC(=O)c1nccnc1Nc1ccc(Cl)cc1.O=[N+]([O-])O>>COC(=O)c1nccnc1Nc1ccc(Cl)cc1[N+](=O)[O-],,C[N+](=O)[O-],,,,val
US20100130559A1,Clc1ccc(I)cn1.OCc1ccccc1Oc1ccccc1>>Ic1ccc(OCc2ccccc2Oc2ccccc2)nc1,,CC(=O)N(C)C,,,,val
US20150126751A1,CCCCCCCCCCCCCCc1cccs1.C[Sn](C)(C)Cl>>CCCCCCCCCCCCCCc1ccc([Sn](C)(C)C)s1,,C1CCOC1,,[Li]CCCC,,val
US06248736B1,CI.O=C(NCc1ccc(Cl)cc1)c1cnc2c(F)cc(CN3CCOCC3)cc2c1O>>Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN3CCOCC3)cc(F)c21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04229448,Cc1ccc(O)cn1.FC(F)(F)c1ccc(Br)cc1>>Cc1ccc(Oc2ccc(C(F)(F)F)cc2)cn1,[Cu],CN(C)C=O,CO,[K],,val
US20060094748A1,Cc1ncc(CNc2ccc(-c3ccccc3S(=O)(=O)NC(C)(C)C)cc2)c(CO)c1O.N#Cc1cccc(CBr)c1>>Cc1ncc(CNc2ccc(-c3ccccc3S(=O)(=O)NC(C)(C)C)cc2)c(CO)c1OCc1cccc(C#N)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04548818,Nc1c(N=O)c(=O)[nH]c(=O)n1C1CC1>>Nc1c(N)n(C2CC2)c(=O)[nH]c1=O,O=[Pt]=O,CN(C)C=O,,,,val
US20090036431A1,BrC(Br)(Br)Br.COc1cc(CO)cc(CO)c1>>COc1cc(CO)cc(CBr)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160130229A1,COC(=O)C(Sc1nc(-c2cccs2)cc(-c2ccc(OC)cc2)c1C#N)c1ccccc1.NO>>COc1ccc(-c2cc(-c3cccs3)nc(SC(C(=O)NO)c3ccccc3)c2C#N)cc1,,C1CCOC1,O,[Na+].[OH-],,val
US20050267149A1,CCCCCCCN.COc1ccccc1CC(=O)O>>CCCCCCCNC(=O)Cc1ccccc1OC,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20140323303A1,Cc1cc(Br)cc(C)c1C1C(=O)C=CC1=O>>Cc1cc(Br)cc(C)c1C1C(=O)CCC1=O,[Zn],CC(=O)O,,,,val
US20070027177A1,CCOC=O.CNC(=O)c1ccc(OC)cc1Cc1ccccc1>>CNC(=O)c1ccc(OC)cc1C(C=O)c1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20080300242A1,COc1cc(C2=CCN(CCF)CC2)ccc1[N+](=O)[O-]>>COc1cc(C2CCN(CCF)CC2)ccc1N,[Pd],CCOC(C)=O,,,,val
US05179125,CN(C)C(=O)Cl.Cc1c(NC(=O)C(CS)Cc2ccccc2)cccc1C(=O)O>>Cc1c(NC(=O)C(CSC(=O)N(C)C)Cc2ccccc2)cccc1C(=O)O,,c1ccncc1,,CCOC(C)=O,,val
US20090093454A1,CNC1CCN(C)CC1.Fc1cccc2nc(CN3CCC[C@H]4CCc5cccnc5[C@H]43)cn12>>CN1CCC(N(C)c2cccc3nc(CN4CCC[C@H]5CCc6cccnc6[C@H]54)cn23)CC1,,CS(C)=O,,,,val
US20140275071A1,Cn1c(=O)n(CCCOC2CCCCO2)c(=O)c2c1nc(OCCOc1cccc(OC(F)(F)F)c1)n2Cc1ccc(Cl)cn1>>Cn1c(=O)n(CCCO)c(=O)c2c1nc(OCCOc1cccc(OC(F)(F)F)c1)n2Cc1ccc(Cl)cn1,,CCO,,CC(=O)Cl,,val
US20120071462A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=S1(=O)NCCOc2ccc(Br)cc21>>CC(C)(C)OC(=O)N1CCOc2ccc(Br)cc2S1(=O)=O,CN(C)c1ccncc1,CCCCCCC,ClCCl,,,val
US05948786,CCO.Nc1nc(C2CCN(C(=O)c3ccccc3)CC2)c2ccccc2n1>>CC(=O)N1CCC(c2nc(N)nc3ccccc23)CC1,,CCO,,[Na+].[OH-],,val
US20040102460A1,CCc1nc(C(F)(F)F)nc2c1ncn2-c1ccc(OCc2ccccc2)cc1>>CCc1nc(C(F)(F)F)nc2c1ncn2-c1ccc(O)cc1,[Pd],CC(=O)O,,CO,[H][H],val
US04093717,CI.COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3ccnc(c13)C2=O>>COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3cc[n+](C)c(c13)C2=O.[I-],,CC(C)=O,,,,val
US20150322024A1,C1CCNCC1.O=C1c2ccccc2C(=O)N1CCCBr>>O=C1c2ccccc2C(=O)N1CCCN1CCCCC1,,Cc1ccccc1,,,,val
US20080119442A1,O=S(=O)(Cl)c1ccc2ccc(Br)cc2c1.c1ccc(CNCc2ccccc2)cc1>>O=S(=O)(c1ccc2ccc(Br)cc2c1)N(Cc1ccccc1)Cc1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20090264406A1,Clc1ccc2ncc(Br)n2n1.Cn1cnc2ccc(C=O)cc21>>Cn1cnc2ccc(C(O)c3cnc4ccc(Cl)nn34)cc21,,C1CCOC1,,CC[Mg]Br,,val
US20050124616A1,CCOC(=O)NC(=S)Nc1cc(-c2ccccc2)n[nH]1>>O=c1[nH]c(=S)[nH]c2cc(-c3ccccc3)nn12,,[Na+],[OH-],O=S(=O)(O)O,,val
US04166178,CCOC(=O)NC(=O)c1ccccc1C(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)OC(C)(C)C)[C@H]2SC1>>CCOC(=O)NC(=O)c1ccccc1C(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1,,O=C(O)C(F)(F)F,,,,val
US20140323486A1,CCNC(=O)Nc1cc(NCc2cccnc2)c(C(=O)OCC)cn1>>CCNC(=O)Nc1cc(NCc2cccnc2)c(C(=O)O)cn1,,CCO,O,Cl,[Li+].[OH-],val
US20160009744A1,CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](CO)C[C@@H](Nc2ncncc2C(=O)c2ccc(Cc3cccc(Cl)c3)s2)[C@H]1F.NS(=O)(=O)Cl>>NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ncncc2C(=O)c2ccc(Cc3cccc(Cl)c3)s2)[C@@H](F)[C@@H]1O,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20090264445A1,COC(=O)[C@H](CC1CCCCC1)N1CC(Oc2cccc(OC(F)(F)F)c2)=CC1=O>>O=C(O)[C@H](CC1CCCCC1)N1CC(Oc2cccc(OC(F)(F)F)c2)=CC1=O,,C1CCOC1,O,[Li+].[OH-],,val
US04810806,COC(=O)C(F)(F)F.OCCCl>>COC1(C(F)(F)F)OCCO1,,O,,CS(C)=O,[H-].[Na+],val
US20150299149A1,CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@@H]4N)no2)cc1C#N.COC(=O)[C@@H](C)OS(C)(=O)=O>>CCC(=O)ON[C@H]1CCc2c(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)cccc21,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110212945A1,COc1ncc([N+](=O)[O-])cc1-c1ccccc1>>COc1ncc(N)cc1-c1ccccc1,[Pd],CCO,,,,val
US20090318439A1,COC(=O)CBr.O=c1c2cc(Br)oc2ccn1-c1ccc2[nH]ncc2c1>>COC(=O)Cn1ncc2cc(-n3ccc4oc(Br)cc4c3=O)ccc21,,CS(C)=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060025433A1,CC[Al](C#N)CC.O=C1C=CCCC1>>N#CC1CCCC(=O)C1,,Cc1ccccc1,,,,val
US20050065118A1,COC(=O)CCc1cccc(OC)c1.O=Cc1cccc(Br)c1>>COC(=O)CCc1cccc(Oc2cccc(C=O)c2)c1,O=[Cu],c1ccncc1,,O=C([O-])[O-].[K+].[K+],,val
US20080021011A1,CC(O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CC(=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,O=[Mn]=O,C1COCCO1,,,,val
US20030176643A1,CC(C)(C)Cl.Cc1ccc(F)cc1>>Cc1ccc(F)c(C(C)(C)C)c1,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20140249129A1,Cn1ncc2c1CNC2.N#Cc1ccc(C2C3=C(CCCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)O)cc1>>Cn1ncc2c1CN(C(=O)CN1C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CCC3)C1c1ccc(C#N)cc1)C2,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20060019965A1,CCc1ccc(-c2nc3cccc(N4CCNCC4)c3[nH]2)cc1.O=[N+]([O-])c1cc(CBr)ccc1F>>CCc1ccc(-c2nc3cccc(N4CCN(Cc5ccc(F)c([N+](=O)[O-])c5)CC4)c3[nH]2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20110207729A1,CC(C)(C)OC(=O)N1CCNCC1.COC(=O)c1ccc2c(c1)C(Cl)CCC2>>COC(=O)c1ccc2c(c1)C(N1CCN(C(=O)OC(C)(C)C)CC1)CCC2,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20070021454A1,CC(C)Oc1cccc(C#N)c1>>CC(C)Oc1cccc(CN)c1,[Ni],CCO,,,,val
US04556669,CC1=C(C(=O)Nc2ccccc2Cl)SC2=NCCN21>>CC1=C(C(=O)Nc2ccccc2Cl)SC2=NCCN21,,O,,Cl,,val
US20140356322A1,COCOc1ccc2c(c1)C[C@@H](CCCCOCCOCCOCCOCC(=O)OC(C)(C)C)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](OCOC)CC[C@@H]12>>C[C@]12CC[C@@H]3c4ccc(O)cc4C[C@@H](CCCCOCCOCCOCCOCC(=O)O)[C@H]3[C@@H]1CC[C@@H]2O,,C1CCOC1,,Cl,,val
US20070129410A1,CC[C@@]12C[C@@](C)(O)[C@@](O)(c3nccs3)C[C@H]1CCc1cc(O)ccc12.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCC12CC(C)(O)C(O)(c3nccs3)CC1CCc1cc(OS(C)(=O)=O)ccc12,,C1CCOC1,,[H-].[Na+],,val
US20050203078A1,CC[C@H](N)c1nc2cc(Cl)ccc2[nH]1.Cc1cc(C(=O)O)ccc1N1CCOCC1=O>>CC[C@H](NC(=O)c1ccc(N2CCOCC2=O)c(C)c1)c1nc2cc(Cl)ccc2[nH]1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20090209607A1,C=Cc1cnn(C)c1-c1cc(C(=O)OC)sc1C>>CCc1cnn(C)c1-c1cc(C(=O)OC)sc1C,[Pd],CO,,,,val
US20090291981A1,C=C(Cl)CCl.CCOC(=O)C(C)C>>C=C(Cl)CC(C)(C)C(=O)OCC,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20150344437A1,CC(=O)c1ccc(S(=O)(=O)Cl)cc1.CNOC>>CON(C)S(=O)(=O)c1ccc(C(C)=O)cc1,,ClCCl,,c1ccncc1,,val
US20120028939A1,COc1cc(-c2cc3ncccc3c(O)n2)cc(OC)c1OC.COc1ccc([C@H](C)N2C[C@H]([C@H](C)O)CC2=O)cc1>>COc1ccc([C@H](C)N2C[C@H]([C@@H](C)Oc3nc(-c4cc(OC)c(OC)c(OC)c4)cc4ncccc34)CC2=O)cc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140221335A1,N.N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)O)cc1>>N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(N)=O)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20150376136A1,CN1CC(C)(C2=CCCCC2)C(=O)NC1=O.O=C(CBr)c1ccccc1>>CN1CC(C)(C2=CCCCC2)C(=O)N(CC(=O)c2ccccc2)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US04000142,Cc1cnc2c(c1)CCCC2.S=C=N[Si](N=C=S)(N=C=S)N=C=S>>Cc1cnc2c(c1)CCCC2C(N)=S,,O,c1ccccc1,Cl,[Li]CCCC,val
US20110274638A1,CCCCOC1(c2ccccc2C)CN(C(=O)C(Cc2ccc(OC)cc2O)NC(=O)OC(C)(C)C)C1.O=C(O)C(F)(F)F>>CCCCOC1(c2ccccc2C)CN(C(=O)C(N)Cc2ccc(OC)cc2O)C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20020160996A1,COc1ccc(CCC(=O)Cl)cc1.Cc1c(C)c2c(c(C)c1N)C(c1ccc(C(C)C)cc1)C(C)(C)O2>>COc1ccc(CCC(=O)Nc2c(C)c(C)c3c(c2C)C(c2ccc(C(C)C)cc2)C(C)(C)O3)cc1,,CCCCCC,CCOC(C)=O,,,val
US20030069238A1,NC(=S)Nc1cccc(Br)n1.O=CCCl>>Brc1cccc(Nc2nccs2)n1,,CCO,O,,,val
US20100125062A1,O=C1CCC(c2cccnc2F)CC1.Oc1ccc(Nc2nc3ccccc3s2)cc1>>O=C1CCC(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1,,CN1CCCC1=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040097485A1,BrP(Br)Br.OCc1ccc(Br)c(O)c1>>Oc1cc(CBr)ccc1Br,,ClC(Cl)Cl,,,,val
US05703075,CC(=O)c1cccc(O)c1O.COC(=O)CN1CCOCC1>>O=C1CC(=CN2CCOCC2)Oc2c(O)cccc21,,C1CCOC1,O,CC(C)(C)[O-].[K+],,val
US20080306059A1,CC(C)(Br)C(=O)Br.COC(=O)CC12CCCC(c3ccccc3)(CC1)CC2>>COC(=O)CC12CCCC(c3ccc(C(=O)C(C)(C)Br)cc3)(CC1)CC2,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20050038035A1,Cc1ccc(C(=O)Nc2ccc(C(=O)CCc3ccccn3)cc2)c(-c2ccc(C(F)(F)F)cc2)c1>>Cc1ccc(C(=O)Nc2ccc(C(O)CCc3ccccn3)cc2)c(-c2ccc(C(F)(F)F)cc2)c1,,CO,,[BH4-].[Na+],,val
US20160214945A1,CC(C)(C)[Si](C)(C)OCC(Br)c1c(F)cccc1F.N#CCc1ccc(F)cc1>>CC(C)(C)[Si](C)(C)OCC(c1c(F)cccc1F)C(C#N)c1ccc(F)cc1,,C1CCOC1,,O,CC(C)(C)[O-].[K+],val
US20110076291A1,CN(C(=O)c1cc2c(s1)-c1ccc(Br)cc1OCC2)c1cc(C(=O)O)ccc1Cl.CN1CCNCC1>>CN1CCN(C(=O)c2ccc(Cl)c(N(C)C(=O)c3cc4c(s3)-c3ccc(Br)cc3OCC4)c2)CC1,,C1CCOC1,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130336965A1,CON.C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](NC(=O)OC(C)(C)C)C1=O>>CO/N=C1\[C@@H](C)C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@H]1N,,CCO,c1ccncc1,Cl,,val
US20110275673A1,CCCCCCO.O=[N+]([O-])c1ccc(CBr)cc1>>CCCCCCOCc1ccc([N+](=O)[O-])cc1,O=[Ag-],ClCCl,,,,val
US20130190307A1,O=P(Cl)(Cl)Cl.O=[N+]([O-])c1cnc2ccc(Cl)nc2c1O>>O=[N+]([O-])c1cnc2ccc(Cl)nc2c1Cl,,CN(C)C=O,,,,val
US20030229119A1,Clc1ccc2c(Cl)ccnc2c1.NC1CCC(N)CC1>>N[C@@H]1CC[C@H](Nc2ccnc3cc(Cl)ccc23)CC1,,CCO,,,,val
US04276364,CN(C)C(=S)Cl.Nc1ccc(NNC=O)cc1>>CN(C)C(=S)Nc1ccc(NNC=O)cc1,,CC#N,,CCN(CC)CC,,val
US20020013230A1,COc1ncc(OC)c(Cl)n1.NN>>COc1ncc(OC)c(NN)n1,,CO,,,,val
US20060106016A1,C=C1CC(NC(=O)OC(C)(C)C)C(C(=O)OC)C1>>C=C1CC(NC(=O)OC(C)(C)C)C(C(=O)O)C1,,CO,O,[Li]O,,val
US20060135530A1,CON(C)C(=O)c1cc(O[Si](C)(C)C(C)(C)C)ccc1N.Cc1cccc([Mg]Br)c1>>Cc1cccc(C(=O)c2cc(O[Si](C)(C)C(C)(C)C)ccc2N)c1,,CCOCC,,C1CCOC1,,val
US20140194411A1,CI.O=C(OCc1ccccc1)N1CCc2ccc3c(c2CC1)C(O)C(F)(F)C3>>COC1c2c(ccc3c2CCN(C(=O)OCc2ccccc2)CC3)CC1(F)F,,C1CCOC1,O,[BH4-].[Na+],,val
US20050070583A1,CCOC(=O)COc1ccc(S)cc1C(F)(F)F.OCC=C(c1ccco1)c1ccco1>>CCOC(=O)COc1ccc(SCC=C(c2ccco2)c2ccco2)cc1C(F)(F)F,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090318385A1,CN.O=Cc1ccc(I)n2nc(C(F)(F)F)cc12>>CNc1ccc(C=O)c2cc(C(F)(F)F)nn12,,C1CCOC1,,,,val
US20150141406A1,N#CCc1ccc(-c2nn(-c3c(F)cccc3F)c3c(Cl)c[nH]c(=O)c23)cc1.OO>>NC(=O)Cc1ccc(-c2nn(-c3c(F)cccc3F)c3c(Cl)c[nH]c(=O)c23)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US05866576,Br.CC(=O)O.Cn1cnc2c1c(=O)n(CCCC(O)CO)c(=O)n2C>>CC(=O)OC(CBr)CCCn1c(=O)c2c(ncn2C)n(C)c1=O,,CC(=O)O,,ClCCl,O=C([O-])O.[Na+],val
US04435403,CC(=O)c1cc2c(cn1)[nH]c1ccccc12.ONCl>>CC(=NO)c1cc2c(cn1)[nH]c1ccccc12,,CO,,[K+].[OH-],,val
US05001144,Cc1cc(C2=C(/C=C/[C@H]3C[C@H](O[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)CC(=O)O3)C(C)(C)CC(N3C(=O)c4ccccc4C3=O)C2)ccc1F>>Cc1cc(C2=C(/C=C/[C@H]3C[C@H](O)CC(=O)O3)C(C)(C)CC(N3C(=O)c4ccccc4C3=O)C2)ccc1F,,CC(=O)O,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080096874A1,CCOC(=O)[C@@H]1CC[C@@H](Oc2ccc(NC(=O)C(=O)OC)cc2)CC1.NN>>CCOC(=O)[C@@H]1CC[C@@H](Oc2ccc(NC(=O)C(=O)NN)cc2)CC1,,CCO,,CCOCC,O,val
US04479000,COc1cc([N+](=O)[O-])ccc1N.O=C(Cl)OCc1ccccc1>>COc1cc([N+](=O)[O-])ccc1NC(=O)OCc1ccccc1,,CC(C)=O,,CN(C)C=O,,val
US20130296333A1,O=[N+]([O-])c1ccc(Cl)c(-c2ncc(-c3ccccc3)[nH]2)c1>>Nc1ccc(Cl)c(-c2ncc(-c3ccccc3)[nH]2)c1,,CCO,,,,val
US20120184542A1,CSc1ncc2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1.NC(CO)c1ccccc1>>CSc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CO)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05563137,CCN(CC)CCN1c2cc(Cl)ccc2S[C@H]2[C@@H](O)[C@H](O)[C@@H](CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)O[C@H]21.CN(C)C=O.COCCl>>CCN(CC)CCN1c2cc(Cl)ccc2S[C@H]2[C@@H](OCOC)[C@H](OCOC)[C@@H](CO)O[C@H]21,,O,,C1CCOC1,[H-].[Na+],val
US20120040954A1,CO.COCCOc1cc(F)cc2nc(-c3cc(C)nc(C)c3)[nH]c(=O)c12>>COCCOc1cc(OC)cc2nc(-c3cc(C)nc(C)c3)[nH]c(=O)c12,,CN(C)C=O,O,CC(=O)O,C[O-].[Na+],val
US20100298336A1,CCOC(=O)c1c(F)cncc1CC>>CCc1cncc(F)c1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050032786A1,CC(C)(C)OC(=O)N1CCCC1c1ccnc(-c2nc(=O)c3ccccc3s2)c1.Cl>>Cl.O=c1nc(-c2cc(C3CCCN3)ccn2)sc2ccccc12,,CCOC(C)=O,,,,val
US20100216788A1,O=[N+]([O-])c1ccc(F)c(Cl)c1.Oc1cccc(Oc2ccccc2)c1>>O=[N+]([O-])c1ccc(Oc2cccc(Oc3ccccc3)c2)c(Cl)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04010177,CNCC1CC1.ClCc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2>>CN(Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2)CC1CC1,,C1CCOC1,,[I-].[K+],,val
US04946771,CC(=O)NC1=NN(c2c(Cl)cc(Cl)cc2Cl)C(=O)C1Br.c1cn[nH]c1>>CC(=O)NC1=NN(c2c(Cl)cc(Cl)cc2Cl)C(=O)C1c1cc[nH]n1,,CCOC(C)=O,,,,val
US20050004182A1,COc1ccc(CNC(=O)c2ccc(CNC(=O)Cc3cccc(CC(C)NC[C@H](O)c4ccc(-n5c(C)ccc5C)nc4)c3)cc2)cc1OC.NO>>COc1ccc(CNC(=O)c2ccc(CNC(=O)Cc3cccc(CC(C)NC[C@H](O)c4ccc(N)nc4)c3)cc2)cc1OC.N,,CCO,,Cl,,val
US20140228348A1,CC(CO[Si](C)(C)C(C)(C)C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1>>CC(CO)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1,,C1CCOC1,ClCCl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US08691865B2,NC1CC[C@H]2CN(Cc3ccccc3)C[C@@H]12.O=C(O)C1(c2ccccc2)CCCC1>>O=C(N[C@@H]1CC[C@H]2CN(Cc3ccccc3)C[C@H]21)C1(c2ccccc2)CCCC1,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US08318760B2,C=C(Br)CCO.OB(O)c1cccc(Cl)c1>>C=C(CCO)c1cccc(Cl)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20070259851A1,CC(C)[Si](Cl)(C(C)C)C(C)C.COc1ccc2[nH]ccc2n1>>COc1ccc2c(ccn2[Si](C(C)C)(C(C)C)C(C)C)n1,,C1CCOC1,,[H-].[Na+],,val
US20100029772A1,C=CCOC(=O)C(Cc1ccc(C(=O)OC)cc1)C(=O)OCC=C.COC(=O)c1ccc(CCBr)cc1>>C=CCOC(=O)C(CCc1ccc(C(=O)OC)cc1)(Cc1ccc(C(=O)OC)cc1)C(=O)OCC=C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090298807A1,Cc1nc(C(=O)N2CCOC3(CCNCC3)C2)cs1.OCCc1ccc(CBr)cc1>>Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(CCO)cc4)CC3)C2)cs1,,CC#N,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20050154039A1,NNC(=O)Cc1ccccc1.S=C=Nc1ccccc1>>O=C(Cc1ccccc1)NNC(=S)Nc1ccccc1,,ClCCl,,,,val
US20010012848A1,CC(=O)O[C@@H]1CCc2ccc(NC(=O)N3CCCC3)cc2[C@H]1NC(=O)c1ccc(Cl)c(Cl)c1>>O=C(N[C@@H]1c2cc(NC(=O)N3CCCC3)ccc2CC[C@H]1O)c1ccc(Cl)c(Cl)c1,,CO,,C[O-].[Na+],,val
US20150353533A1,CC(C)(C)OC(=O)N[C@H]1CCc2cc(B3OC(C)(C)C(C)(C)O3)ccc2NC1=O>>CC1(C)OB(c2ccc3c(c2)CC[C@H](N)C(=O)N3)OC1(C)C,,ClCCl,,Cl,,val
US20060074084A1,CC(=O)NCCN.CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3[nH]c(C(=O)O)c(-c4cccc(F)c4)c3c2)cc1>>CC(=O)NCCNC(=O)c1[nH]c2ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc2c1-c1cccc(F)c1,,CO,ClCCl,,,val
US20140171645A1,CSc1ccccc1.O=C1CCC(=O)N1Br>>CS(=O)c1ccccc1,,ClCCl,,CO,O,val
US20030078251A1,CCOC(=O)c1cc2cccc(NC(=O)C[C@H]3O[C@H](c4cccc(OC)c4OC)c4cc(Cl)ccc4N(CC(C)(C)COC(C)=O)C3=O)c2[nH]1>>COc1cccc([C@H]2O[C@H](CC(=O)Nc3cccc4cc(C(=O)O)[nH]c34)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,O,,CCO,[Na+].[OH-],val
US20150232462A1,COCCO.N#Cc1ccc(F)cc1CBr>>COCCOCc1cc(F)ccc1C#N,,C1CCOC1,,[H-].[Na+],,val
US20140275029A1,Cn1ccc(COc2ccc([N+](=O)[O-])c(NCc3ccc(OC(F)(F)F)cc3F)c2)n1>>Cn1ccc(COc2ccc(N)c(NCc3ccc(OC(F)(F)F)cc3F)c2)n1,[Pt],CCOC(C)=O,,N#N,,val
US20160024063A1,CC(C)(C)OC(=O)N1CC=C(OS(=O)(=O)C(F)(F)F)CC1.CS(=O)(=O)c1ccc(B(O)O)cc1>>CC(C)(C)OC(=O)N1CC=C(c2ccc(S(C)(=O)=O)cc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05185358,CC(C)c1cccc(C(C)C)c1N=C=O.CCCCCCCCCCCCCc1nnc(N)o1>>CCCCCCCCCCCCCc1nnc(NC(=O)Nc2c(C(C)C)cccc2C(C)C)o1,,CC#N,,CCN(CC)CC,,val
US04374138,CCN=C=O.Nc1ccc2[nH]cc(C(=O)O)c(=O)c2c1>>CCNC(=O)Nc1ccc2[nH]cc(C(=O)O)c(=O)c2c1,,CN(C)C=O,,CCN(CC)CC,,val
US03950320,CC(=O)OC(C)=O.CCC(C(=O)C(C)C(O)C(C)CCc1c(N)cc(C)c(O)c1C(=O)O)C1OC(CC)(C2CCC(O)(CC)C(C)O2)CC1C>>CCC(C(=O)C(C)C(O)C(C)CCc1c(NC(C)=O)cc(C)c(O)c1C(=O)O)C1OC(CC)(C2CCC(O)(CC)C(C)O2)CC1C,,CC(=O)O,,O=C([O-])[O-].[Na+].[Na+],,val
US20030013704A1,CC(C)(C)OC(=O)NC1(CN(CCO)Cc2ccc(Cl)c(C(=O)NCC34CC5CC(CC(C5)C3)C4)c2)CC1>>NC1(CN(CCO)Cc2ccc(Cl)c(C(=O)NCC34CC5CC(CC(C5)C3)C4)c2)CC1,,C1COCCO1,CO,Cl,N,val
US20100204265A1,CC(C)(C)OC(=O)N1CC=C(c2cc(C(F)(F)F)c3nc(C(=O)N4CC=C(c5nccs5)C4)c(Cl)n3c2)CC1>>O=C(c1nc2c(C(F)(F)F)cc(C3=CCNCC3)cn2c1Cl)N1CC=C(c2nccs2)C1,,C1CCOC1,,C1COCCO1,Cl,val
US03939115,CNC(=O)c1ccc(C(=O)OC)cc1.COC(=O)c1ccc(C(=O)NN)cc1>>COC(=O)c1ccc(-c2nnc(-c3ccc(C(=O)OC)cc3)n2C)cc1,,ClC(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20070003680A1,CC(C)(C(=O)O)c1ccc(Br)cc1.CC(C)OB(OC(C)C)OC(C)C>>CC(C)(C(=O)O)c1ccc(B(O)O)cc1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20090062366A1,COc1cc(C(=O)O)ccc1NC(=O)N1C[C@H](c2ccccc2)[C@@H](CN(C(=O)OC(C)(C)C)[C@H](C)c2cccc3ccccc23)C1.Cl>>COc1cc(C(=O)O)ccc1NC(=O)N1C[C@H](c2ccccc2)[C@@H](CN[C@H](C)c2cccc3ccccc23)C1.Cl,,C1COCCO1,,,,val
US05627270,O[C@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1.c1ccc(SSc2ccccc2)cc1>>c1ccc(COC[C@H]2OC(Sc3ccccc3)[C@H](OCc3ccccc3)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)cc1,,ClCCl,,CCCCP(CCCC)CCCC,,val
US20110263571A1,CC(C)(C)OC(=O)N1CCNCC1.Cc1ccc(Br)c(C)n1>>Cc1ccc(N2CCNCC2)c(C)n1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20060116515A1,CCOC(=N)C1CCCN1C(=O)OCc1ccccc1.S>>CCOC(=S)C1CCCN1C(=O)OCc1ccccc1,,C1CCOC1,,Cl,c1ccncc1,val
US20160009688A1,CC(C)N.Cc1ccc(C(=O)N2CCC(c3ccc(-n4ccnc4)cc3)CC2)cc1NC(=O)c1ccc(Cl)nc1>>Cc1ccc(C(=O)N2CCC(c3ccc(-n4ccnc4)cc3)CC2)cc1NC(=O)c1ccc(NC(C)C)nc1,,C1COCCO1,ClCCl,,,val
US20120289702A1,CC(=O)c1ccccc1Oc1cnc2ccccc2c1.NO>>CC(=NO)c1ccccc1Oc1cnc2ccccc2c1,,c1ccncc1,,Cl,Cl,val
US20120283297A1,COC(=O)C(C)Cn1ncc2c(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)cccc21>>CC(C)Oc1ccc(-c2nc(-c3cccc4c3cnn4CC(C)C(=O)O)no2)cc1Cl,,CCO,,Cl,[Na+].[OH-],val
US04410716,COC(=O)Cc1ccc2c(c1)C(OC)=Cc1ccccc1C2>>COC(=O)Cc1ccc2c(c1)C(=O)Cc1ccccc1C2,,O,,Br,,val
US20120295934A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1C2CN(Cc3ccccc3)CC2CCN1c1ccc(OC(F)(F)F)cc1>>CC(C)(C)OC(=O)N1CC2CCN(c3ccc(OC(F)(F)F)cc3)C(=O)C2C1,[Pd],CO,,,,val
US05395939,CCOCCl.Oc1cccc(Cl)n1>>CCOCOc1cccc(Cl)n1,,ClCCl,,[H-].[Na+],,val
US20090298812A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(NCC1(N2CCN(C3CC3)CC2)CCNCC1)C(F)(F)F>>CC(C)(C)OC(=O)N1CCC(CNC(=O)C(F)(F)F)(N2CCN(C3CC3)CC2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150361059A1,CC(C)(C)OC(=O)N[C@@H](COc1c(F)cccc1[N+](=O)[O-])C(=O)O>>CC(C)(C)OC(=O)N[C@@H](COc1c(N)cccc1F)C(=O)O,[Pd],CO,,,,val
US20080318943A1,COC(=O)/C=C(\CCl)OC.COc1ccc(CN)cc1>>COC1=CC(=O)N(Cc2ccc(OC)cc2)C1,,CC#N,,CCN(CC)CC,,val
US20130116289A1,Cc1ccccc1-c1ccc(-c2nc(-c3ccc(C(CO[Si](C)(C)C(C)(C)C)N[C@H](C)C(=O)OC(C)(C)C)cc3)no2)cc1C(F)(F)F>>Cc1ccccc1-c1ccc(-c2nc(-c3ccc(C(CO)N[C@H](C)C(=O)OC(C)(C)C)cc3)no2)cc1C(F)(F)F,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05424333,CC(C)(C)NN.O=C(Cl)Cc1ccccc1.O=C(Cl)c1ccccc1>>CC(C)(C)N(NC(=O)Cc1ccccc1)C(=O)c1ccccc1,,CCCCCC,Cc1ccccc1,Cl,[Na+].[OH-],val
US20150065519A1,Cc1noc(C)c1B1OC(C)(C)C(C)(C)O1.O=S(=O)(Nc1ccc(-c2csc(Br)n2)c(Cl)c1)C(F)(F)F>>Cc1noc(C)c1-c1nc(-c2ccc(NS(=O)(=O)C(F)(F)F)cc2Cl)cs1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20140249147A1,Cn1ccc(C(=O)Cl)n1.Nc1ccc2ncc(-c3ccccc3F)n2n1>>Cn1ccc(C(=O)Nc2ccc3ncc(-c4ccccc4F)n3n2)n1,,ClCCl,,CCN(CC)CC,,val
US20080146523A1,CC(C)(C)C(=Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)c1ccccc1>>CC(C)(C)C(Cc1c[nH]cn1)c1ccccc1,[Pd],CO,,ClCCl,,val
US20040082639A1,COc1cc2c(cc1O)CCC2=O.ClCC1CO1>>COc1cc2c(cc1OCC1CO1)CCC2=O,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20110118230A1,CC1(C)OB(c2cnc3c(c2)c2cc(C#N)ncc2n3COCC[Si](C)(C)C)OC1(C)C.C[N+]1([O-])CCOCC1>>C[Si](C)(C)CCOCn1c2cnc(C#N)cc2c2cc(O)cnc21,,C1CCOC1,,,,val
US06303593B1,CCOC(OCC)OCC.COC(=O)c1cccc(O)c1N>>COC(=O)c1cccc2ncoc12,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20100004222A1,CC(C)(C)C(=O)Cl.Cc1cc(/C=C/C(F)(F)F)ccc1C(=O)Nc1ccc2c(c1)NCC2>>Cc1cc(/C=C/C(F)(F)F)ccc1C(=O)Nc1ccc2c(c1)N(C(=O)C(C)(C)C)CC2,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05026715,O=C(Cl)CCl.O=Cc1ccc[nH]1>>O=Cc1cc(C(=O)CCl)c[nH]1,,CC(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20040023974A1,COc1ccc(CN2C(=O)CN(Cc3ccc(C(=O)OCc4ccccc4)cc3)S2(=O)=O)c(OC)c1>>COc1ccc(CN2C(=O)CN(Cc3ccc(C(=O)O)cc3)S2(=O)=O)c(OC)c1,[Pd],CCO,CCOC(C)=O,[H][H],,val
US20110172429A1,NNC(N)=S.O=C(O)c1ccoc1>>NC(=S)NNC(=O)c1ccoc1,,C1CCOC1,ClCCl,O=S(Cl)Cl,O=C([O-])O.[Na+],val
US20070299068A1,CCOc1ccc2cc(-c3ccc([N+](=O)[O-])cc3)n(C(=O)OC(C)(C)C)c2c1>>CCOc1ccc2cc(-c3ccc([N+](=O)[O-])cc3)[nH]c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160168139A1,O=[N+]([O-])c1ccc(F)c(S(=O)O)c1.Sc1ccccc1Br>>O=[N+]([O-])c1ccc(Sc2ccccc2Br)c(S(=O)O)c1,,O,,Cl,[Na+].[OH-],val
US20090239845A1,COC(=O)c1ccc(C(=O)CCCNC(=O)OC(C)(C)C)cc1>>O=C(O)c1ccc(C2=NCCC2)cc1,,C1CCOC1,,CCO,Cl,val
US20150087663A1,C[C@@H](CCl)NC(=O)c1c(N)ncnc1Cl>>C[C@H]1COC(c2c(N)ncnc2Cl)=N1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20050171109A1,CC(C)(CC(O)(C=O)C(F)(F)F)c1cccc2c1OCO2.Nc1cccc2c1CNC2=O>>CC1(C)CC(O)(C(F)(F)F)C(Nc2cccc3c2CNC3=O)c2ccc3c(c21)OCO3,,CC(=O)O,,,,val
US07067540B2,COC(=O)c1cccc(-n2c(C)cc(OCc3ccc(F)cc3F)cc2=O)c1>>COC(=O)c1cccc(-n2c(C)cc(O)cc2=O)c1,,CC#N,,O=C1CCC(=O)N1Br,,val
US20150284411A1,C=C[Mg]Br.O=C1CO[C@@H]2[C@H](Oc3nc4nc(-c5ccc(-c6ccccc6)cc5)c(Cl)cc4[nH]3)CO[C@H]12>>C=C[C@@]1(O)CO[C@@H]2[C@H](Oc3nc4nc(-c5ccc(-c6ccccc6)cc5)c(Cl)cc4[nH]3)CO[C@@H]21,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20130158042A1,CC1CNCCN1C(=O)OC(C)(C)C.Cc1cccc(-n2cnc(C(=O)O)n2)c1>>Cc1cccc(-n2cnc(C(=O)N3CCN(C(=O)OC(C)(C)C)C(C)C3)n2)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US09248117B2,CC(C)(C)OCl.COCCOCCOCC[N+](C)(C)CCN1CC(C)(C)NC1=O.Cc1ccc(S(=O)(=O)[O-])cc1>>COCCOCCOCC[N+](C)(C)CCN1CC(C)(C)N(Cl)C1=O.Cc1ccc(S(=O)(=O)[O-])cc1,,CO,,,,val
US20090163508A1,CC(C)(C)OC(=O)N1CCN(c2cc(Cl)ncn2)CC1.OB(O)Oc1ccccc1F>>CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccccc3F)ncn2)CC1,,O,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20080234262A1,CC1CN(c2nc(Cl)nc3c2cnn3C2CCN(Cc3ccccc3)CC2)CCO1.COC(=O)Cl>>COC(=O)N1CCC(n2ncc3c(N4CCOC(C)C4)nc(Cl)nc32)CC1,,ClCCCl,,O=C([O-])[O-].[K+].[K+],,val
US20130240784A1,CCCC1CCC(O)(c2ccc(Br)cc2F)CC1>>CCCC1CC=C(c2ccc(Br)cc2F)CC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2ccc(O)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21.O=S(=O)(Cl)CCCCl>>CC(C)(C)OC(=O)n1c(-c2ccc(OS(=O)(=O)CCCCl)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21,,CC#N,,CCN(CC)CC,,val
US20040002524A1,COc1ccc(-n2c(-c3ccc[nH]3)nc3ccccc32)cc1>>Oc1ccc(-n2c(-c3ccc[nH]3)nc3ccccc32)cc1,,ClCCl,,BrB(Br)Br,,val
US05308857,NC(N)=Nc1nc(-c2ccc(CNC(=S)NC(=O)c3ccccc3)o2)cs1>>NC(=S)NCc1ccc(-c2csc(N=C(N)N)n2)o1,,CO,,[Na+].[OH-],,val
US20040054172A1,CN(CCON)C(=O)OC(C)(C)C.Cc1cc(I)ccc1Nc1c(C(=O)Oc2c(F)c(F)c(F)c(F)c2F)ccc(F)c1F>>Cc1cc(I)ccc1Nc1c(C(=O)NOCCN(C)C(=O)OC(C)(C)C)ccc(F)c1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20110112074A1,COC1=N[C@H](C(C)C)C(OC)=N[C@H]1Cc1cc(-c2ccc(Cl)s2)on1.O=C(O)C(F)(F)F>>COC(=O)[C@@H](N)Cc1cc(-c2ccc(Cl)s2)on1,,CC#N,,O=C([O-])O.[Na+],,val
US20080287396A1,CCCC(=O)Oc1ccc(P(=O)(CP(=O)(OCC)OCC)OCC)cc1C(C)(C)CC(=O)OCc1ccccc1>>CCOP(=O)(CP(=O)(OCC)c1ccc(OC(=O)C(C)C)c(C(C)(C)CC(=O)O)c1)OCC,[Pd],,,CO,,val
US20030144138A1,Brc1ccccc1P(c1cccc2ccccc12)c1cccc2ccccc12.CCOP(Cl)OCC>>CCOP(OCC)c1ccccc1P(c1cccc2ccccc12)c1cccc2ccccc12,,C1CCOC1,,,,val
US20100317863A1,Brc1ccc2c(c1)CCCN2.CCC1C[N@@]1S(=O)(=O)c1c(C)cc(C)cc1C>>CC[C@@H](CN1CCCc2cc(Br)ccc21)NS(=O)(=O)c1c(C)cc(C)cc1C,,CO,,,,val
US20110195954A1,O=C(c1cc(Cl)ncn1)N1CCc2cc(Cl)ccc21.O=c1[nH]c2ncccc2n1C1CCNCC1>>O=C(c1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)ncn1)N1CCc2cc(Cl)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130289058A1,CCOC(=O)C1(C(=O)OCC)CCC(=O)CC1.O=S(=O)(N(c1ccc(Cl)cn1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)C1(C(=O)OCC)CC=C(OS(=O)(=O)C(F)(F)F)CC1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20070167423A1,CC(=O)Nc1cccc(C(=O)CN2CCN(c3cccc4nc(C)ccc34)CC2)c1>>CC(=O)Nc1cccc(C(O)CN2CCN(c3cccc4nc(C)ccc34)CC2)c1,,ClCCl,,[BH4-].[Na+],,val
US20150119362A1,SC1CCCC1.[O-][n+]1c(Cl)cc(Cl)c2c1CCC2>>[O-][n+]1c(SC2CCCC2)cc(Cl)c2c1CCC2,,C1COCCO1,ClCCl,CC(C)(C)[O-].[K+],,val
US20140080806A1,C1CNC1.Cn1ncc(C(=O)c2c(Cl)ncnc2Cl)c1Br>>Cn1ncc(C(=O)c2c(Cl)ncnc2N2CCC2)c1Br,,CC#N,,CCN(C(C)C)C(C)C,,val
US20120122838A1,CB(O)O.COc1ccc(Cn2cnc3c(N[C@@H](C)c4cc5cccc(Cl)c5c(Cl)n4)ncnc32)cc1>>COc1ccc(Cn2cnc3c(N[C@@H](C)c4cc5cccc(Cl)c5c(C)n4)ncnc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100075952A1,Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCOCC1)CCC2.O=C1Cc2cc(S(=O)(=O)Cc3ccc(F)cc3)ccc2N1>>Cc1c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4ccc(F)cc4)cc32)[nH]c2c1C(=O)N(CCN1CCOCC1)CCC2,,CCO,,C1CCNCC1,,val
US04237308,CC/C=C\CC1(C(=O)OC)C(=O)C=CC1CC(=O)OC>>CC/C=C\CC1C(=O)C=CC1CC(=O)OC,,CS(C)=O,O,[Cl-].[Na+],,val
US20090105474A1,CC(C)(C)OC(=O)c1ccc(CCc2ccccc2)cc1Nc1ccc(N2CCOCC2)cc1>>O=C(O)c1ccc(CCc2ccccc2)cc1Nc1ccc(N2CCOCC2)cc1,,O=C(O)C(F)(F)F,,,,val
US04931444,COc1ccc(N2CCN(c3ccc(-n4cn[nH]c4=O)cc3)CC2)cc1.O=S(=O)(OCC(F)(F)F)c1ccc2ccccc2c1>>COc1ccc(N2CCN(c3ccc(-n4cnn(CC(F)(F)F)c4=O)cc3)CC2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20040157804A1,Fc1ccc(CCBr)cc1.O=C1CCC(=O)N1>>O=C1CCC(=O)N1CCc1ccc(F)cc1,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20110183976A1,Cc1cccc(CO)n1.Cl>>Cc1cccc(CCl)n1,,O=S(Cl)Cl,,,,val
US20100135999A1,CCOC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)c2ccc(C)cc2n1>>Cc1ccc2c(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)cc(C(=O)O)nc2c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20090280230A1,CCOC(=O)C(=O)Cl.COc1ccc(CN)c(OC)c1>>CCOC(=O)C(=O)NCc1ccc(OC)cc1OC,,C1CCOC1,,CCN(CC)CC,,val
US20070179151A1,CC(C)O.COc1cc2cc(Nc3cc(C4CC4)[nH]n3)nc(Cl)c2cc1F>>COc1cc2cc(Nc3cc(C4CC4)[nH]n3)nc(OC(C)C)c2cc1F,,CC(C)O,,,,val
US05459137,CC(=O)N1N=C(c2ccc(NC(=O)CCl)cc2)c2cc3c(cc2CC1C)OCO3.CN>>CNCC(=O)Nc1ccc(C2=NN(C(C)=O)C(C)Cc3cc4c(cc32)OCO4)cc1,,CCO,,CCN(CC)CC,Cl,val
US20100152180A1,CO.O=C(O)c1ccc(F)c([N+](=O)[O-])c1>>COC(=O)c1ccc([N+](=O)[O-])c(F)c1,,CN(C)C=O,ClCCl,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20130281392A1,Nc1cc(Br)cnc1N.O=C(O)C(F)(F)F>>FC(F)(F)c1nc2ncc(Br)cc2[nH]1,,Cl,,,,val
US20140343083A1,CC(Br)C1CC1(F)F.Oc1ccc(Br)nc1>>FC1(F)CC1COc1ccc(Br)nc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150045349A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cn1ccc(Br)n1>>Cn1ccc(B2OC(C)(C)C(C)(C)O2)n1,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20120245136A1,COc1cc(C(=O)N2CCC3(C=Cc4ccccc4O3)CC2)ccc1OC(C)C.O=C(OO)c1cccc(Cl)c1>>COc1cc(C(=O)N2CCC3(CC2)Oc2ccccc2C2OC23)ccc1OC(C)C,,ClCCl,,,,val
US20080161371A1,CC(C)[C@H]1CC[C@H](C)C[C@@H]1OC(=O)Cl.O=C(Nc1ncc(C(c2ccccc2Cl)N2CC[C@@H](O)C2)s1)C1(c2ccc3c(c2)OCO3)CC1>>CC(C)[C@H]1CC[C@H](C)C[C@@H]1OC(=O)O[C@@H]1CCN(C(c2cnc(NC(=O)C3(c4ccc5c(c4)OCO5)CC3)s2)c2ccccc2Cl)C1,CN(C)c1ccncc1,CO,ClCCl,,,val
US20060281773A1,C1CCNC1.O=S(=O)(Cl)c1cc(Cl)ccc1O>>O=S(=O)(c1cc(Cl)ccc1O)N1CCCC1,,ClC(Cl)Cl,,,,val
US20100093726A1,O=C(c1ccc(CN2CCCC2)cc1)c1cccc(Cl)c1.O=C(c1ccc(Cl)cc1)c1ccc(CBr)c(F)c1>>O=C(c1ccc(Cl)cc1)c1ccc(CN2CCCC2)c(F)c1,,CO,ClC(Cl)Cl,C1CCNC1,,val
US20100069473A1,CC(C)(C)OC(=O)N[C@@H](CC#Cc1ccc(Br)cc1)C(=O)OC1CCCC1>>CC(C)(C)OC(=O)N[C@@H](C/C=C\c1ccc(Br)cc1)C(=O)OC1CCCC1,[Pd],,,c1ccc2ncccc2c1,,val
US20160068515A1,CC(C)(C)OC(=O)N1CCN(c2nn[nH]n2)CC1.O=C(O)C(F)(F)F>>CC(C)(C)OC(=O)N1CCN(c2nnc(C(F)(F)F)o2)CC1,,CC#N,,,,val
US04670536,CC(=O)c1ccc(N)cc1.O=C1C=CC(=O)O1>>CC(=O)c1ccc(N2C(=O)C=CC2=O)cc1,,CC(=O)N(C)C,,CO,,val
US04292234,CCNCC.CO[Si](CCCS)(OC)OC.O=S(=O)(Cl)Cl>>CCN(CC)SSCCC[Si](OC)(OC)OC,,CCCCC,,,,val
US20120122773A1,C=C(C)Cl.O=C(O)O.O=[N+]([O-])c1ccc(O)cc1>>C=C(C)OC(=O)Oc1ccc([N+](=O)[O-])cc1,,c1ccncc1,,ClC(Cl)Cl,,val
US20080076752A1,CC(C)(C)OC(=O)N[C@@H]1C(=O)Nc2ccccc2O[C@@H]1c1ccccc1.CC(C)I>>CC(C)N1C(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](c2ccccc2)Oc2ccccc21,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110311461A1,COc1ccc(NC(C(=O)O)c2ccsc2)cc1.O[C@H]1CN2CCC1CC2>>COc1ccc(NC(C(=O)O[C@H]2CN3CCC2CC3)c2ccsc2)cc1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20100016401A1,CC(=O)CCl.CCOC(=O)c1c[nH]c(=S)[nH]1>>CCOC(=O)c1cn2c(C)csc2n1,,CCO,,O=P(Cl)(Cl)Cl,,val
US05359068,CC(C)(C)OC(=O)N1CCNCC1.O=CCc1cc(Cl)c([N+](=O)[O-])cc1Cl>>CC(C)(C)OC(=O)N1CCN(CCc2cc(Cl)c([N+](=O)[O-])cc2Cl)CC1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140018313A1,CC1(C)OB(c2ccc3cc(-c4cnc([C@@H]5CCCN5)[nH]4)ccc3c2)OC1(C)C.COC(=O)N[C@H](C(=O)O)[C@@H](C)OC(F)F>>COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3cc(B4OC(C)(C)C(C)(C)O4)ccc3c2)[nH]1)[C@@H](C)OC(F)F,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080234306A1,CC1C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)[C@@H](O5)C1=O.O=C(OO)c1cccc(Cl)c1>>CC1C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CC[N+]3([O-])CC2CC2)[C@@H](O5)C1=O,,CO,ClCCl,,,val
US20080269211A1,CCOC(=O)Cc1ccc(NC(=O)OC(C)(C)C)cn1>>CCOC(=O)C[C@H]1CC[C@@H](NC(=O)OC(C)(C)C)CN1,O=[Pt],CC(=O)O,CCO,,,val
US20160251339A1,CCc1cn(S(=O)(=O)c2ccc(OC)c(N3CCN(C(=O)C(Cl)(Cl)Cl)CC3)c2)c2cc(Br)ccc12>>CCc1cn(S(=O)(=O)c2ccc(OC)c(N3CCNCC3)c2)c2cc(Br)ccc12,,C1CCOC1,,[K+].[OH-],,val
US20120302608A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1cc(CN)cnc1C(F)F>>CCOC(=O)c1cc(CNC(=O)OC(C)(C)C)cnc1C(F)F,,C1CCOC1,,CCN(CC)CC,Cl,val
US20070179151A1,CN1CCNCC1.Cc1cc(Nc2cc3cc(OS(=O)(=O)C(F)(F)F)ccc3c(OC(C)C)n2)n[nH]1>>Cc1cc(Nc2cc3cc(N4CCN(C)CC4)ccc3c(OC(C)C)n2)n[nH]1,,CN1CCCC1=O,,,,val
US20160039808A1,OCc1cccc2ccccc12.Oc1nc(Cl)nc2cnccc12>>Oc1nc(OCc2cccc3ccccc23)nc2cnccc12,,C1COCCO1,,[H-].[Na+],,val
US20100305092A1,N#Cc1ccc(C(N)=O)cc1.NO>>NC(=O)c1ccc(C(N)=NO)cc1,,CCO,,,,val
US20100119479A1,Nc1ccc2c(c1)CNC2.O=C(Cl)CBr>>O=C(CBr)Nc1ccc2c(c1)CNC2,,C1CCOC1,,c1ccncc1,,val
US20150210869A1,CCC(C)=O.CCOC(=O)CBr.ClCCl.O=C([O-])[O-]>>O=C1Cc2ccccc2OC1=O,,ClCCl,,O,,val
US20080045546A1,Nc1ccc(Cl)c(C(F)(F)F)c1.O=C(CBr)Nc1cccc2c1CC(O)CC2>>O=C(CNc1ccc(Cl)c(C(F)(F)F)c1)Nc1cccc2c1CC(O)CC2,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090170828A1,CC(C)(C)OC(=O)N1CC(O)C1.Oc1ccccc1Br>>CC(C)(C)OC(=O)N1CC(Oc2ccccc2Br)C1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20140343052A1,CCl.Fc1cccc(Br)n1.O=C(O)[C@H]1CCCN1>>COC(=O)[C@H]1CCCN1c1cccc(Br)n1,,C1COCCO1,,CCN(CC)CC,O,val
US20150252036A1,COc1c(F)cc(F)cc1CN(CC(OC)OC)S(=O)(=O)c1ccc(C)cc1>>Oc1c(F)cc(F)c2ccncc12,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100105658A1,CCOC(=O)C1(Cl)OC1c1c(F)cccc1F.NC(N)=S>>CCOC(=O)c1nc(N)sc1-c1c(F)cccc1F,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20040014971A1,O=C(Nc1ccc(N2CCN(Cc3ccccc3)CC2)cc1)c1ccccc1-c1ccccc1>>O=C(Nc1ccc(N2CCNCC2)cc1)c1ccccc1-c1ccccc1,[Pd],CO,,[H][H],,val
US20110230486A1,CC(=O)c1c(C)cc(I)cc1C.Cc1ccc(S)cc1>>CC(=O)c1c(C)cc(Sc2ccc(C)cc2)cc1C,O=[Cu-],CN(C)C=O,O,[K+].[OH-],,val
US08895313B2,CC(=O)Oc1ccc(C(=O)O)cc1[N+](=O)[O-].COc1ccc2nc(-c3ccc(N)cc3)sc2c1>>COc1ccc2nc(-c3ccc(NC(=O)c4ccc(OC(C)=O)c([N+](=O)[O-])c4)cc3)sc2c1,,C1CCOC1,,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US06124278,O=C1c2ccccc2C(=O)N1CO.Oc1ccc2c(c1)OCO2>>O=C1c2ccccc2C(=O)N1Cc1cc2c(cc1O)OCO2,,ClC(Cl)Cl,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,O,val
US06288100B1,CCCc1nc2cc(C(=O)c3ccccc3)ccc2[nH]1.Clc1ccc(CBr)cc1Cl>>CCCc1nc2cc(C(=O)c3ccccc3)ccc2n1Cc1ccc(Cl)c(Cl)c1,,CN(C)C=O,,[H-].[Na+],,val
US20040024034A1,CCOCC.Cc1oc(-c2ccccc2)nc1C=O>>CCOC(=O)C=Cc1nc(-c2ccccc2)oc1C,,C1CCOC1,CCOCC,[Li+].[OH-],,val
US20110183953A1,Brc1nccs1.N#Cc1cc(B(O)O)ccc1F>>N#Cc1cc(-c2nccs2)ccc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,N#N,O=C([O-])[O-].[K+].[K+],val
US20140206690A1,CCN(CC)CC(C)N.O=S(=O)(Cl)c1cccc(Br)c1>>CCN(CC)CCCNS(=O)(=O)c1cccc(Br)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060281759A1,CC1(C)NCCNC1=O.CI>>CN1CCNC(=O)C1(C)C,,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20040106622A1,COC(=O)[C@H](CNC(=O)C1CCN(c2cccc(NC3=NCCCN3)c2)CC1)NC(=O)OCc1ccccc1>>O=C(N[C@@H](CNC(=O)C1CCN(c2cccc(NC3=NCCCN3)c2)CC1)C(=O)O)OCc1ccccc1,,CO,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20020193367A1,CC(C)(C)OC(=O)CC(=O)c1cccc(-c2nnc(COC3CCCCO3)o2)c1.CN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F>>CN(C)c1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3nnc(CO)o3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060040999A1,COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN[C@@H](C)[C@H](N)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.NS(N)(=O)=O>>COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN1[C@@H](C)[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)NS1(=O)=O,,c1ccncc1,,,,val
US20100298336A1,Cn1cc(Cl)c(CBr)n1.Oc1cc(C(F)(F)F)nc(S)n1>>Cn1cc(Cl)c(CSc2nc(O)cc(C(F)(F)F)n2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05405861,Fc1ccc(C2(Cn3cncn3)CO2)c(F)c1.O=C(O)CCS>>OC(CS)(Cn1cncn1)c1ccc(F)cc1F,,CN(C)C=O,,Cl,[H-].[Na+],val
US03959312,CCOC(=O)C(=O)OC(C)(C)C.[Li]C#CC(C)C>>CC(C)C#CC(=O)C(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20150191419A1,Br.CC(C)(C)OC(=O)NCC(=O)CCC(=O)OC(C(=O)OC(C)(C)C)c1ccccc1>>Br.NCC(=O)CCC(=O)OC(C(=O)O)c1ccccc1,,CC(=O)O,,,,val
US20110224083A1,COC(=O)CCNC(=O)C(C)(C)Br.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(O)c(Cl)cc2F)c1=O>>COC(=O)CCNC(=O)C(C)(C)Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20060030735A1,C=CC(=O)OCC.CCOC(=O)C[S+](C)C>>CCOC(=O)[C@@H]1C[C@H]1C(=O)OCC,,ClC(Cl)Cl,,,,val
US20090186891A1,COc1ncccc1N.NNC(=O)c1ccc2nc(-c3c(Cl)cccc3Cl)[nH]c2c1.S=C(n1ccnc1)n1ccnc1>>COc1ncccc1Nc1nnc(-c2ccc3nc(-c4c(Cl)cccc4Cl)[nH]c3c2)o1,,CCOC(C)=O,CN(C)C=O,CCN=C=NCCCN(C)C,,val
US20020061865A1,CCNc1nc(SC)nnc1C=O.COc1cc(CC#N)cc(OC)c1>>CCn1c(=N)c(-c2cc(OC)cc(OC)c2)cc2nnc(SC)nc21,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20030144308A1,Br.BrBr.CCOc1cc2ncnc(Nc3cccc(C(C)=O)c3)c2cc1OCC>>Br.CCOc1cc2ncnc(Nc3cccc(C(=O)CBr)c3)c2cc1OCC,,Br,CC(=O)O,Cl,,val
US06680338B2,CC(C)(C)OC(=O)N1CCC(O)CC1.O=C(O)Cc1cccs1>>CC(=O)SC1CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,CCOC(C)=O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030171377A1,CCOC(=O)CCBr.c1ccc(COc2ccc3[nH]ccc3c2)cc1>>O=C(O)CCn1ccc2cc(OCc3ccccc3)ccc21,,CS(C)=O,O,Cl,[K+].[OH-],val
US20150353533A1,O=C(N[C@H]1CCc2ccccc2NC1=O)c1nnc(Cc2ccccc2)[nH]1.O=C1CCC(=O)N1Cl>>O=C(N[C@H]1CCc2cc(Cl)ccc2NC1=O)c1nnc(Cc2ccccc2)[nH]1,,CC(=O)N(C)C,,,,val
US06057369,COc1ccc(S(=O)(=O)[C@H](CCCCc2ccccc2)[C@H](CCOc2ccccc2)C(=O)O)cc1.C[Si](C)(C)ON>>COc1ccc(S(=O)(=O)C(CCCCc2ccccc2)C(CCOc2ccccc2)C(=O)NO)cc1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20090143366A1,O=C(c1cccc([N+](=O)[O-])c1)c1cc(I)ccc1F.OB(O)c1ccncc1>>O=C(c1cccc([N+](=O)[O-])c1)c1cc(-c2ccncc2)ccc1F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20100120669A1,NNC(N)=S.O=C(O)COc1ccccc1Cl>>NC(=S)NNC(=O)COc1ccccc1Cl,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040077605A1,O=[N+]([O-])c1cnc(Cl)c(I)c1>>Nc1cnc(Cl)c(I)c1,[Fe],,,,,val
US20070259951A1,COC(=O)c1cc(NS(C)(=O)=O)ccc1-c1ccc(C(F)(F)F)cc1>>CS(=O)(=O)Nc1ccc(-c2ccc(C(F)(F)F)cc2)c(CO)c1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100010053A1,CCOC(=O)CNC(=O)CCc1c[nH]c2c(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)cccc12>>CC(C)Oc1ccc(-c2nc(-c3cccc4c(CCC(=O)NCC(=O)O)c[nH]c34)no2)cc1Cl,,C1CCOC1,,Cl,[Na+].[OH-],val
US20150353553A1,COC(=O)c1nc(N[C@H](CCCO)C2CCC2)c2c(n1)nc(-c1cccc(C)c1)n2Cc1ccc(C(F)(F)F)cc1>>Cc1cccc(-c2nc3nc(C(=O)O)nc(N[C@H](CCCO)C4CCC4)c3n2Cc2ccc(C(F)(F)F)cc2)c1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US04264614,CN(C)Cc1cccc(OCCCN)c1.S=C=S>>CN(C)Cc1cccc(OCCCN=C=S)c1,,CC(C)=O,,CCN(CC)CC,,val
US20030100770A1,COc1cc(OCC(=O)N2CCC[C@@H]2C(=O)OC(C)(C)C)ccc1OCC(=O)N1CCC[C@@H]1C(=O)OC(C)(C)C>>COc1cc(OCC(=O)N2CCC[C@@H]2C(=O)O)ccc1OCC(=O)N1CCC[C@@H]1C(=O)O,,O=C(O)C(F)(F)F,,,,val
US20060172358A1,CCc1cc2c(=O)c(-c3nc(C)cs3)c(C(=O)[O-])oc2cc1O.Oc1ccccc1>>CCc1cc2c(=O)c(-c3nc(C)cs3)c(C(=O)Oc3ccccc3)oc2cc1O,,CCOC(C)=O,ClCCl,,,val
US20050033006A1,CCCCS(=O)(=O)Cl.Nc1ccncc1>>CCCCS(=O)(=O)Nc1ccncc1,,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20150111935A1,CCCCCCC/C=C/C=C/CN=[N+]=[N-]>>CCCCCCC/C=C/C=C/CN,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040204449A1,COc1ccc2c(c1)C(CO)CN(C(=O)OC(C)(C)C)C2.CS(=O)(=O)Cl>>COc1ccc2c(c1)C(COS(C)(=O)=O)CN(C(=O)OC(C)(C)C)C2,,ClCCl,,CCN(CC)CC,O,val
US20080306086A1,COC(=O)C1CC(N(Cc2ccc(F)cc2F)C(=O)OCC(Cl)(Cl)Cl)CN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CC(N(Cc2ccc(F)cc2F)C(=O)OCC(Cl)(Cl)Cl)CC1C(=O)O,,CO,,[Li+].[OH-],,val
US20100035871A1,CCOC(=O)C1CN(C(=O)OC(C)(C)C)c2cccc(Br)c2O1>>CC(C)(C)OC(=O)N1CC(CO)Oc2c(Br)cccc21,,C1CCOC1,,O,[BH4-].[Li+],val
US20160052940A1,C1O[C@@H]2CN[C@H]1C2.CS(=O)(=O)c1cc(-c2cnc([NH2+][O-])c(OC(F)F)c2)nc(C2CC2(F)F)n1>>[O-][NH2+]c1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3(F)F)n2)cc1OC(F)F,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060217374A1,CCOC(=O)CC(=O)CCl.COc1cccc(S)c1>>CCOC(=O)CC(=O)CSc1cccc(OC)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060270635A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC=Cc1ccc(N)cc1>>CC=Cc1ccc(NC(=O)OC(C)(C)C)cc1,,C1COCCO1,O,CCN(CC)CC,,val
US05641788,COc1ccc(C(=O)c2cc(OC)c(OC)cc2N)cc1OC.O=C(CCl)CCl>>COc1ccc(-c2c(Cl)c(CCl)nc3cc(OC)c(OC)cc23)cc1OC,,CC(=O)O,,O=S(=O)(O)O,,val
US20140336185A1,COc1ccc(OC)c(CC(=O)Nc2ccc(C(=O)N(CC(=O)OC(C)(C)C)Cc3ccc(-c4nc(-c5ccc(-c6ccc(C)cc6)cc5)no4)cc3)cc2)c1>>COc1ccc(OC)c(CC(=O)Nc2ccc(C(=O)N(CC(=O)O)Cc3ccc(-c4nc(-c5ccc(-c6ccc(C)cc6)cc5)no4)cc3)cc2)c1,,C1CCOC1,,CO,[Li+].[OH-],val
US20160002175A1,Cc1ccc(Cl)cc1B(O)O.Nc1nc(Cl)cc(Cl)n1>>Cc1ccc(Cl)cc1-c1cc(Cl)nc(N)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20020013460A1,CCN1CCN(c2nc(-c3ccc(OCOC)cc3)cc3cscc23)CC1>>CCN1CCN(c2nc(-c3ccc(O)cc3)cc3cscc23)CC1,,CCO,,Cl,[Na+].[OH-],val
US20140155381A1,COC(=O)Cc1ccc2oc(Br)cc2c1.Cc1noc(C)c1C=O>>COC(=O)Cc1ccc2oc(C(O)c3c(C)noc3C)cc2c1,,C1CCOC1,,CC(C)[Mg]Cl,[Cl-].[NH4+],val
US06136823,CCOC(=O)c1cn(-c2ccc(F)c(OC)c2)c2c(Cl)c(F)c(F)cc2c1=O>>COc1cc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)c(Cl)c32)ccc1F,,CC(=O)O,,Cl,,val
US20020103209A1,ClC(Cl)Cl.Clc1nc2ccccc2[nH]1.Cn1c2c(c3ccccc31)CN(CCCN)CC2>>Cl.Cl.Cn1c2c(c3ccccc31)CN(CCCNc1nc3ccccc3[nH]1)CC2,[Cu],ClC(Cl)Cl,,,,val
US07148221B2,CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4N)ncn3)cccc2s1.CC(=O)OC(C)=O>>CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4NC(C)=O)ncn3)cccc2s1,,Cc1ccccc1,,,,val
US05594081,CC(=O)c1ccc(C)cc1.Cc1ccc(C=O)cc1>>Cc1ccc(C=CC(=O)c2ccc(C)cc2)cc1,,CCO,O,[Na+].[OH-],,val
US20130210844A1,O=[N+]([O-])c1cccc2c(Oc3ccc(F)c(C(F)(F)F)c3)ccnc12>>Nc1cccc2c(Oc3ccc(F)c(C(F)(F)F)c3)ccnc12,[Fe],CCO,O,[Cl-].[NH4+],,val
US20110124613A1,C[C@@]1(COS(=O)(=O)c2cccc([N+](=O)[O-])c2)CO1.OCc1ccc(F)cc1O>>OCc1ccc(F)cc1OC[C@@H]1CO1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20130085151A1,C[Mg]Cl.O=Cc1cc2cc(Cl)sc2nc1Cl>>CC(O)c1cc2cc(Cl)sc2nc1Cl,,C1CCOC1,C1CCOC1,,,val
US20020198380A1,CC(=O)Cl.Fc1ccc(Nc2nc(Cl)nc3c2N=C(Cl)NC3)cc1Cl>>CC(=O)N1Cc2nc(Cl)nc(Nc3ccc(F)c(Cl)c3)c2N=C1Cl,,CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US20050227987A1,Nc1ccc2c(c1)CCCC2=O.O=C(Cl)c1ccc(-c2ccccc2)cc1>>O=C(Nc1ccc2c(c1)CCCC2=O)c1ccc(-c2ccccc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US05861414,CC(C)(C)OC(=O)N1CCC(CCBr)CC1>>C=CC1CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20110301109A1,CC(=O)CCC(C)=O.CCCOc1ccc(N)cc1-c1nc(CC)c(CC)c(=O)[nH]1>>CCCOc1ccc(-n2c(C)ccc2C)cc1-c1nc(CC)c(CC)c(=O)[nH]1,,CCO,,CC(=O)O,,val
US20100069473A1,C#CC[C@H](NC(=O)OC(C)(C)C)C(=O)O.OC1CCCC1>>C#CC[C@H](NC(=O)OC(C)(C)C)C(=O)OC1CCCC1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US05532267,CS(=O)(=O)O.N=C(N)c1ccc2cc(OC(=O)c3ccc(CNC(=O)CCCC(=O)O)o3)ccc2c1>>CS(=O)(=O)O.N=C(N)c1ccc2cc(OC(=O)c3ccc(CNC(=O)CCCC(=O)O)o3)ccc2c1,,CC(C)=O,,CN(C)C=O,Cl,val
US20120009151A1,CCc1cccc(N)c1.Cc1ccc(CN)o1.Clc1nc(Cl)nc(Cl)n1>>CCc1cccc(Nc2nc(Cl)nc(NCc3ccc(C)o3)n2)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20060287341A1,COc1ncnc(OC)c1Br.OB(O)c1ccncc1>>COc1ncnc(OC)c1-c1ccncc1,,C1CCOC1,CCO,O=C([O-])[O-].[K+].[K+],,val
US04112095,CCCC(=O)NN.FC(F)(F)c1ccc(-c2ccc(Cl)nn2)cc1>>CCCc1nnc2ccc(-c3ccc(C(F)(F)F)cc3)nn12,,CCCCO,,,,val
US06040338,CN(NS(C)(=O)=O)S(C)(=O)=O.COC(=O)Cl>>COC(=O)N(N(C)S(C)(=O)=O)S(C)(=O)=O,,CC(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US06350749B1,CC(=O)CCl.O=C1CC(=O)CC(c2ccccc2C(F)(F)F)C1>>Cc1coc2c1C(=O)CC(c1ccccc1C(F)(F)F)C2,,CN(C)C=O,,[H-].[Na+],,val
US20110178132A1,NC(=NO)c1cc(-c2ccccc2)ccn1.O=C(n1ccnc1)n1ccnc1>>O=c1nc(-c2cc(-c3ccccc3)ccn2)[nH]o1,,C1CCOC1,O,C1CCC2=NCCCN2CC1,Cl,val
US20040106604A1,CN1CCNCC1.O=C(Cl)COc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1>>CN1CCN(C(=O)COc2ccc3c(-c4c(-c5ccccn5)nn5c4CCC5)ccnc3c2)CC1,,ClCCl,,,,val
US06018056,Brc1ccc(OCCN2CCCCC2)cc1.COc1ccc(-c2sc3cc(OC)ccc3c2C#N)cc1>>COc1ccc(C2Sc3cc(OC)ccc3C2(C=N)c2ccc(OCCN3CCCCC3)cc2)cc1,,C1CCOC1,,[Li]C(C)CC,,val
US20120263670A1,CCN1Cc2c(Cl)cc(Cl)cc2C(c2cccc(S(=O)(=O)Cl)c2)C1.[N-]=[N+]=NCCOCCOCCOCCN>>CCN1Cc2c(Cl)cc(Cl)cc2C(c2cccc(S(=O)(=O)NCCOCCOCCOCCN=[N+]=[N-])c2)C1,,ClCCl,,,,val
US20040242884A1,CNC[C@@H](O)c1cnccn1.Cc1c(CCl)sc2c(=O)c(C(=O)NCc3ccc(F)cc3)cn(C)c12>>Cc1c(CN(C)C[C@@H](O)c2cnccn2)sc2c(=O)c(C(=O)NCc3ccc(F)cc3)cn(C)c12,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20130331571A1,CC(C)[C@H]1CN(c2ccc(Br)nc2)C(=O)N1CC(=O)Nc1cccc(C(F)(F)F)c1.CCO.CN(C)C=O>>COC(=O)c1ccc(N2C[C@H](C(C)C)N(CC(=O)Nc3cccc(C(F)(F)F)c3)C2=O)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,CN(C)C=O,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20140275071A1,BrCCCOC1CCCCO1.Cn1c(=O)[nH]c(=O)c2c1nc(Br)n2Cc1ccc(Cl)cc1>>Cn1c(=O)n(CCCOC2CCCCO2)c(=O)c2c1nc(Br)n2Cc1ccc(Cl)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100113502A1,CC1CCN(C(=O)c2ccc3c(c2)c2c(n3S(=O)(=O)C3CC3)CCN(C(=O)OC(C)(C)C)C2)CC1>>CC1CCN(C(=O)c2ccc3c(c2)c2c(n3S(=O)(=O)C3CC3)CCNC2)CC1,,C1COCCO1,,Cl,,val
US20020049243A1,COC(=O)c1ccc(N(C)C(=O)CN(C)C(=O)OCc2ccccc2)cc1>>CN(CC(=O)N(C)c1ccc(CO)cc1)C(=O)OCc1ccccc1,,C1CCOC1,,CO,,val
US20120322785A1,CN1CCNCC1.Cc1ccc(F)cc1-c1ccc2cc(NC(=O)Oc3ccc([N+](=O)[O-])cc3)ncc2c1>>Cc1ccc(F)cc1-c1ccc2cc(NC(=O)N3CCN(C)CC3)ncc2c1,,ClCCl,,CN(C)C=O,,val
US20120122863A1,COC(=O)[C@@H](C1CCCCC1)n1c(=O)c2ccccc2n(Cc2cn(C)c3cccc(C)c23)c1=O>>Cc1cccc2c1c(Cn1c(=O)n([C@@H](C(=O)O)C3CCCCC3)c(=O)c3ccccc31)cn2C,,C1COCCO1,O,,,val
US20150307491A1,CC(C)(C)OC(=O)N1CCO[C@H](COc2nc(-c3ccc(N4CCOCC4)cc3)cc3nccnc23)C1>>c1cnc2c(OC[C@@H]3CNCCO3)nc(-c3ccc(N4CCOCC4)cc3)cc2n1,,CCOC(C)=O,Cl,,,val
US20040259874A1,CCC(=O)NCC(O)c1ccc(OCc2ccccc2)cc1>>CCCNCC(O)c1ccc(OCc2ccccc2)cc1,,C1CCOC1,,,,val
US06043065,CO.O=C(O)C(O)c1ccccc1[N+](=O)[O-]>>COC(=O)C(O)c1ccccc1[N+](=O)[O-],O=S(=O)(O)O,,,,,val
US20070281933A1,CCS(=O)(=O)Cl.NC(=O)c1cc(-c2ccsc2)cc2c(C3CCNCC3)n[nH]c12>>CCS(=O)(=O)N1CCC(c2n[nH]c3c(C(N)=O)cc(-c4ccsc4)cc23)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US20040034189A1,C#Cc1cc([Si](C)(C)C)ccc1C>>C#Cc1ccc(C)cc1,,O,,CO,[K+].[OH-],val
US20130190297A1,CI.Nc1nc(N2CCN(C(=O)COc3ccc(Cl)cc3)CC2)c2nc(-c3ccc(F)cc3)[nH]c2n1>>Cn1c(-c2ccc(F)cc2)nc2c(N3CCN(C(=O)COc4ccc(Cl)cc4)CC3)nc(N)nc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130203727A1,Cc1cc2cc(-c3ccncc3)ccc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O.Cc1ccc2c(c1)CC(C)CC2=O>>Cc1ccc2c(-c3ccc(Cl)cc3)c(C(OC(C)(C)C)C(=O)O)c(C)cc2c1,,CCO,,[BH4-].[Na+],,val
US20070010671A1,CN(C)c1nc(N[C@H]2CC[C@@H](C(=O)O)CC2)nc2ccccc12.NC(=O)c1cccc([N+](=O)[O-])c1>>CN(C)c1nc(N[C@H]2CC[C@@H](C(=O)NCc3cccc(N)c3)CC2)nc2ccccc12,[Pd],CCO,,,,val
US20060063779A1,N#Cc1ccc(S(=O)(=O)CCCO)cc1.O=C1CCC(=O)N1Br>>N#Cc1ccc(S(=O)(=O)CCCBr)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050043323A1,Nc1nccc(-c2cc3c([nH]2)CCNC3=O)n1.O=CC1CCCCC1>>O=C1NCCc2[nH]c(-c3ccnc(NCC4CCCCC4)n3)cc21,,CN(C)C=O,,O=C(O)C(F)(F)F,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20030078258A1,c1ccc(CNCc2ccccc2)cc1.c1ccc(OC[C@@H]2CO2)cc1>>O[C@H](COc1ccccc1)CN(Cc1ccccc1)Cc1ccccc1,,CO,,,,val
US06187769B1,BrCCCCCBr.CC1=COc2ccc(C)cc2C(=O)N1>>CC1=COc2ccc(C)cc2C(=O)N1CCCCCBr,,CN(C)C=O,,[H-].[Na+],,val
US20090036492A1,COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.Cc1ccc2cc(F)ccc2c1C=O>>COc1cc(O)c2c(c1C(=O)NCc1c(C)ccc3cc(F)ccc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,,CC#N,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20090264445A1,CC(C)(O)Cn1ccc(N)n1.COc1cccc(OC2=CC(=O)N([C@@H](CC3CCCC3)C(=O)O)C2)c1Cl>>COc1cccc(OC2=CC(=O)N([C@@H](CC3CCCC3)C(=O)Nc3ccn(CC(C)(C)O)n3)C2)c1Cl,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US04698337,C=CCn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCC(F)(F)F)c3csc(NC=O)n3)[C@H]2SC1>>C=CCn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCC(F)(F)F)c3csc(N)n3)[C@H]2SC1,,CO,,Cl,,val
US20150368238A1,CCOC(=O)CNC(=O)c1cnc2ccc(N3CCC[C@H]3c3cc(F)ccc3F)cn12>>O=C(O)CNC(=O)c1cnc2ccc(N3CCC[C@H]3c3cc(F)ccc3F)cn12,,CCO,,[Li+].[OH-],,val
US04814344,CI.Cc1[nH]c2ccccc2c1C(=O)CCn1ccnc1>>Cc1c(C(=O)CCn2ccnc2)c2ccccc2n1C,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US04261997,COc1ccc2c(c1)c(=O)n1nc(C(N)=O)cc1n2C>>COc1ccc2c(c1)c(=O)n1nc(C#N)cc1n2C,,CN(C)C=O,,O=S(Cl)Cl,,val
US20040006114A1,CCN(CC)S(F)(F)F.CCS(=O)(=O)N(Cc1cccnc1)c1cccc(C(O)c2ccccc2)c1>>CCS(=O)(=O)N(Cc1cccnc1)c1cccc(C(F)c2ccccc2)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US20080027053A1,CC(=O)N(C[C@H]1CN(c2ccc(N3Cc4cn(C)nc4C3)c(F)c2)C(=O)O1)C(=O)OCOC(=O)c1ccc(COP(=O)(OCc2ccccc2)OCc2ccccc2)cc1>>CC(=O)N(C[C@H]1CN(c2ccc(N3Cc4cn(C)nc4C3)c(F)c2)C(=O)O1)C(=O)OCOC(=O)c1ccc(COP(=O)(O)O)cc1,[Pd],CO,,,,val
US20010000513A1,COC(=O)CCC(=O)Cl.Fc1ccc(-c2ccccc2)cc1>>COC(=O)CCC(=O)c1ccc(-c2ccc(F)cc2)cc1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100324041A1,CC(C)(C)OC(=O)N1CCN(c2c(Br)cnc3[nH]ccc23)CC1.OB(O)c1ccc(F)cc1>>CC(C)(C)OC(=O)N1CCN(c2c(-c3ccc(F)cc3)cnc3[nH]ccc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20120277224A1,CC(=O)n1nc(C)c2cc(C(=O)C3C(=O)OC(C)(C)OC3=O)ccc21.CCO>>CCOC(=O)CC(=O)c1ccc2c(c1)c(C)nn2C(C)=O,,CCO,,,,val
US20090093483A1,CCOC(=O)C1(c2ccccc2C#C[Si](CC)(CC)CC)CCN(Cc2ccccc2)CC1>>C#Cc1ccccc1C1(C(=O)OCC)CCN(Cc2ccccc2)CC1,,CO,,CC(C)(C)[O-].[K+],,val
US20120208798A1,C#Cc1ccc2c(c1)[C@H](NC(=O)OC(C)C)C[C@H](C)N2C(C)=O.C[Si](C)(C)N=[N+]=[N-]>>CC(=O)N1c2ccc(-c3c[nH]nn3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C,[Cu]I,CO,,CN(C)C=O,,val
US20110105544A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=S(=O)(NCc1ccccc1)c1cccc(Br)c1>>CC(C)(C)OC(=O)N(Cc1ccccc1)S(=O)(=O)c1cccc(Br)c1,CN(C)c1ccncc1,CC#N,,CCN(C(C)C)C(C)C,O,val
US20140187529A1,CC1(C)OB(c2ccc(N)nc2)OC1(C)C.Nc1ncc(Br)nc1Br.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Nc1ccc(-c2nc(Br)cnc2N)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20160108047A1,CC1(C)OB(C2=CCOC2)OC1(C)C.Cc1cc(N2C(=O)c3nc(Br)n(C(C)C)c3C2c2ccc(Cl)cc2)cn2c(CF)nnc12>>Cc1cc(N2C(=O)c3nc(C4=CCOC4)n(C(C)C)c3C2c2ccc(Cl)cc2)cn2c(CF)nnc12,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US05519133,COc1ccc(Br)c(C(=O)O)c1>>O=C(O)c1cc(O)ccc1Br,,ClCCl,,BrB(Br)Br,O,val
US20070197628A1,NCc1ccc(F)c(F)c1.O=CC=Cc1ccc(Cl)cc1>>Fc1ccc(CNCC=Cc2ccc(Cl)cc2)cc1F,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160009667A1,CS(=O)(=O)Cl.Nc1noc2cc(OCC3CCCCC3)c(C3CC3)cc12>>CS(=O)(=O)Nc1noc2cc(OCC3CCCCC3)c(C3CC3)cc12,,ClCCl,,CCN(CC)CC,,val
US04528282,COC(=O)C(Br)C(=O)OC.C[C@H](N)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C>>COC(=O)C(N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C)C(=O)OC,,ClCCl,,,,val
US20070173506A1,CC(C)(C)OC(=O)Nc1ccc2cnccc2n1>>Nc1ccc2cnccc2n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US05059689,CC1(C)CCCC(C)(C)N1c1nc(Cl)nc(Cl)n1.CCN>>CCNc1nc(Cl)nc(N2C(C)(C)CCCC2(C)C)n1,,CCO,,O,,val
US20130059853A1,COc1ccc(-c2cccc3c2CCC3=O)c(O)c1OC(F)F.CS(=O)(=O)c1ccc(CBr)cc1>>COc1ccc(-c2cccc3c2CCC3=O)c(OCc2ccc(S(C)(=O)=O)cc2)c1OC(F)F,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130102586A1,COc1ccc(Cn2nc(C)c3cc(Nc4ccc(CN5CCN(C)CC5)cc4)cnc32)cc1>>Cc1n[nH]c2ncc(Nc3ccc(CN4CCN(C)CC4)cc3)cc12,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20080221161A1,CCOC(=O)c1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1>>O=C(O)c1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1,,C1CCOC1,,Cl,[Li+].[OH-],val
US04639451,CC(=O)SC(C)C(=O)Nc1ccc(C2=NNC(=O)CC2C)cc1>>CC(S)C(=O)Nc1ccc(C2=NNC(=O)CC2C)cc1,,CO,,Cl,[Na+].[OH-],val
US05807883,C=CC#N.COc1ccc2c(c1)C(N)C(=O)N2c1ccc(F)cc1>>COc1ccc2c(c1)C(N)(CCC#N)C(=O)N2c1ccc(F)cc1,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120264737A1,CCc1cc(C2CCC2)c(C(=O)NN)cc1C(=O)N1CCC(c2ccc(C#N)cc2)CC1.N#CBr>>CCc1cc(C2CCC2)c(-c2nnc(N)o2)cc1C(=O)N1CCC(c2ccc(C#N)cc2)CC1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20020082276A1,COc1ccc(C=O)cc1.COc1ccc2nc(SC)ccc2c1Br>>COc1ccc(C(O)c2c(OC)ccc3nc(SC)ccc23)cc1,,C1CCOC1,CCCCC,[Li]C(C)(C)C,,val
US20110046171A1,CCNC(=NS(=O)(=O)c1ccc(OC)cc1)N1CC(CC)C=N1>>CCNC(=NS(=O)(=O)c1ccc(O)cc1)N1CC(CC)C=N1,,ClCCl,,BrB(Br)Br,,val
US04115568,COC(=O)c1cc(-c2ccccc2)sc1N.O=[N+]([O-])c1cc(F)ccc1F>>COC(=O)c1cc(-c2ccccc2)sc1Nc1ccc(F)cc1[N+](=O)[O-],,ClCCl,,,,val
US20030099900A1,C=C(C)C(=O)OC1(CC)C2CC3CC(C2)CC1C3.C=Cc1ccc(OC(C)=O)cc1>>C=C(C)C(=O)OC1(CC)C2CC3CC(C2)CC1C3.C=Cc1ccc(OC(C)=O)cc1,,CO,,,,val
US20050059710A1,C#Cc1ccc(Nc2c(C(=O)N(C)OC)ccc(F)c2F)c(F)c1>>CCc1ccc(Nc2c(C(=O)N(C)OC)ccc(F)c2F)c(F)c1,[Pd],C1CCOC1,,[H][H],,val
US20060100229A1,CC(=O)Cl.CC(C)Cc1c2c(nn1C)c(N)nc1ccccc12>>CC(=O)Nc1nc2ccccc2c2c(CC(C)C)n(C)nc12,,ClCCl,,CCN(CC)CC,,val
US20100286115A1,Cc1onc(-c2ccccc2)c1C=C(Br)Br>>C#Cc1c(-c2ccccc2)noc1C,,C1CCOC1,,CC(C)[Mg]Cl,[Cl-].[NH4+],val
US20040002508A1,O=[N+]([O-])c1ccc2c(ccn2-c2ccncc2)c1>>Nc1ccc2c(ccn2-c2ccncc2)c1,[Pd],CCO,CCOC(C)=O,,,val
US20150361067A1,CC(=O)c1cc(Cl)c2c(c1Cl)C(=O)N(Cc1c(C)cc(C)nc1OCc1ccccc1)CC2>>Cc1cc(C)c(CN2CCc3c(Cl)cc(C(C)O)c(Cl)c3C2=O)c(OCc2ccccc2)n1,,CO,,[BH4-].[Na+],,val
US20100041642A1,CN1CCN(C(=O)OC(C)(C)C)C(C)(C)C1=O.Cl>>CN1CCNC(C)(C)C1=O.Cl,,CC(C)O,,COC(C)(C)C,,val
US20130210824A1,Cc1ncc2c(I)n[nH]c2n1.Fc1cccc(CBr)c1F>>Cc1ncc2c(I)nn(Cc3cccc(F)c3F)c2n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090069222A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1,,CN(C)C=O,ClCCl,ClCCCl,On1nnc2ccccc21,val
US20130225620A1,C1=COCCC1.COc1c(Br)ccc2nc[nH]c12>>COc1c(Br)ccc2c1ncn2C1CCCCO1,,CCOC(C)=O,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US05998433,C=O.CNC.O=C(c1ccc(-c2ccccc2)cc1)N1CCc2occc2C1>>CN(C)Cc1cc2c(o1)CCN(C(=O)c1ccc(-c3ccccc3)cc1)C2,,CC(=O)O,,,,val
US20160016951A1,COCCNc1ccc2cncc(Cl)c2c1.Cn1cc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)cn1>>COCCNc1ccc2cncc(-c3ccc(-c4cnn(C)c4)cc3)c2c1,,O,,CC#N,O=C([O-])[O-].[Na+].[Na+],val
US05998433,C=O.CNC.O=C(CCCCCc1ccccc1)N1CCc2ccsc2C1>>CN(C)Cc1cc2c(s1)CN(C(=O)CCCCCc1ccccc1)CC2,,CC(=O)O,,,,val
US05284661,BrCc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.CCOC(=O)c1cnc2sc(CC)cc2c1O>>CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnnn3C(c3ccccc3)(c3ccccc3)c3ccccc3)cc2)c2sc(CC)cc2c1=O,,CN(C)C=O,,O,[H-].[Na+],val
US04714774,CC(=O)OC(C)=O.CCCc1c(OCCCOc2ccc(C(=O)O)cc2F)ccc(C(C)=O)c1O>>CCCc1c(OCCCOc2ccc(C(=O)O)cc2F)ccc(C(C)=O)c1OC(C)=O,CN(C)c1ccncc1,CO,,CCN(CC)CC,ClCCl,val
US20030083238A1,CCOC(=O)c1ccc(F)cc1.C[C@H]1CC[C@@H](N2CCNCC2)CC1>>CCOC(=O)c1ccc(N2CCN([C@@H]3CC[C@H](C)CC3)CC2)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US04749813,Cc1ccc([N+](=O)[O-])c(C(F)(F)F)c1>>Cc1ccc(N)c(C(F)(F)F)c1,[Fe],O,,C1COCCO1,Cl,val
US04009200,O=C1C=CC(=O)C2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl>>O=C1CCC(=O)C2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl,[Zn],ClC(Cl)Cl,,CC(=O)O,O,val
US20150158815A1,NC(=O)C(Nc1cncc(Br)c1)c1cccc(Cl)c1.OB(O)c1cc(Cl)ccc1F>>NC(=O)C(Nc1cncc(-c2cc(Cl)ccc2F)c1)c1cccc(Cl)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US05300524,COC1CCC(OC)O1.O=S(O)c1ccccc1>>COC1CCC(S(=O)(=O)c2ccccc2)O1,,ClCCl,,[Ca+2].[Cl-].[Cl-],,val
US20150158847A1,CC1(C=O)CCCN(C(=O)OC(C)(C)C)C1.COP(=O)(OC)C(=[N+]=[N-])C(C)=O>>C#CC1(C)CCCN(C(=O)OC(C)(C)C)C1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20040209901A1,CCN.Cc1cc(F)ccc1-c1nc(S(C)(=O)=O)nc2c1ccc(=O)n2-c1ccccc1F>>CCNc1nc(-c2ccc(F)cc2C)c2ccc(=O)n(-c3ccccc3F)c2n1,,C1CCOC1,,,,val
US20140121187A1,COc1cc(C(C)C)ccc1C1(N)C(=O)c2ccccc2C1=O.O=C(Cl)C1CC1>>COc1cc(C(C)C)ccc1C1(NC(=O)C2CC2)C(=O)c2ccccc2C1=O,,ClCCl,,CCN(CC)CC,,val
US20040077669A1,C[C@@H]1CCC[C@H]1O.Clc1cc(Cl)ncn1>>C[C@@H]1CCC[C@H]1Oc1cc(Cl)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20100298325A1,COc1cccc(N)c1.Clc1ccc(Oc2cccc(N3CCOCC3)c2)cn1>>COc1cccc(Nc2ccc(Oc3cccc(N4CCOCC4)c3)cn2)c1,,C1COCCO1,CCOC(C)=O,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20140213580A1,N#Cc1cc(Nc2ccnc(Cl)c2)c(C2CC2)nc1N1CCN[C@H](C2CC2)C1.O=C(O)C[C@H]1CCO1>>N#Cc1cc(Nc2ccnc(Cl)c2)c(C2CC2)nc1N1CCN(C(=O)C[C@H]2CCO2)[C@H](C2CC2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150336986A1,CC1(C)OCC(CO)O1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC1(C)OCC(COS(=O)(=O)C(F)(F)F)O1,,ClCCl,O,Cc1cccc(C)n1,,val
US20090203750A1,N[C@@H]1C[C@H]1c1ccccc1.O=Cc1ccccc1>>c1ccc(CN[C@@H]2C[C@H]2c2ccccc2)cc1,,CO,,Cl,[BH3-]C#N.[Na+],val
US05135932,CC(=O)NCCNc1ccc(C2=NNC(=O)CC2)cc1N.O=C(n1ccnc1)n1ccnc1>>CC(=O)NCCn1c(O)nc2cc(C3=NNC(=O)CC3)ccc21,,CN(C)C=O,,,,val
US04801722,COC(=O)C(Cc1cccc(C(=O)c2cc(CN(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)c(OC(C)=O)c(CN(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)c2)c1)c1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1>>COC(=O)C(Cc1cccc(C(=O)c2cc(CN(CC(=O)O)CC(=O)O)c(O)c(CN(CC(=O)O)CC(=O)O)c2)c1)c1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1,,O,O=C(O)C(F)(F)F,,,val
US20030162795A1,Cc1cc2cc(Nc3ccnc4cc(-c5cccn5C(=O)OC(C)(C)C)sc34)ccc2[nH]1>>Cc1cc2cc(Nc3ccnc4cc(-c5ccc[nH]5)sc34)ccc2[nH]1,,ClCCl,O,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20110301370A1,CCCCCCCCCC(=O)/C=C(C(=O)OC)/C(=C/C(=O)OC)C(=O)OC>>CCCCCCCCCC(O)C/C(C(=O)OC)=C(\CC(=O)OC)C(=O)OC,,CO,ClCCl,[BH4-].[Na+],[Cl-].[NH4+],val
US20160194316A1,CCN(c1cc(Cl)cc(C(=O)NCc2c(OC)nn(C)c2C)c1C)C1CCN(CCOC)CC1>>CCN(c1cc(Cl)cc(C(=O)NCc2c(C)n(C)[nH]c2=O)c1C)C1CCN(CCOC)CC1,,Cl,,O=C([O-])O.[Na+],,val
US20050227959A1,CI.CN(CC(O)c1ccc(F)cc1)S(=O)(=O)c1ccc(Br)s1>>COC(CN(C)S(=O)(=O)c1ccc(Br)s1)c1ccc(F)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20050113450A1,CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(C(=O)O)cc1.COC(=O)c1cc(Br)ccc1N>>CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(C(=O)Nc2ccc(Br)cc2C(=O)O)cc1,,ClCCl,c1ccncc1,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20040242554A1,Clc1nccnc1N1CCNCC1.O=C1CCC(=O)N1Cl>>Clc1cnc(N2CCNCC2)c(Cl)n1,,ClC(Cl)Cl,,,,val
US06559177B2,COc1cc(F)cc(OC)c1.O=C(Cl)CCl>>COc1cc(F)c(C(=O)CCl)c(OC)c1,,CC(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100239525A1,CCCCNC.CS(=O)(=O)OCCc1ccc(Nc2ncc3c(n2)-c2ccccc2C(c2cccc(Br)c2)C3)cc1>>CCCCN(C)CCc1ccc(Nc2ncc3c(n2)-c2ccccc2C(c2cccc(Br)c2)C3)cc1,,CCN(CC)CC,,,,val
US20100150831A1,COc1ccc2cccnc2c1N1CCCN(C(CC(=O)O)C2CCN(C(=O)OC(C)(C)C)CC2)CC1.NCCN1CCCC1>>COc1ccc2cccnc2c1N1CCCN(C(CC(=O)NCCN2CCCC2)C2CCN(C(=O)OC(C)(C)C)CC2)CC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04034088,CCOC(=O)Cn1ccnc1SC>>CSc1nccn1CC(=O)O,,O=S(=O)(O)O,,,,val
US20130053366A1,CN1CCc2[nH]c3cc(C(F)(F)F)ccc3c2C1.c1cc(C2CO2)ccn1>>CN1CCc2c(c3ccc(C(F)(F)F)cc3n2CC(O)c2ccncc2)C1,,CN(C)C=O,,[H-].[Na+],,val
US04261996,COc1cccc2c(=O)n3nc(C(N)=O)cc3[nH]c12>>COc1cccc2c(=O)n3nc(C#N)cc3[nH]c12,,O=P(Cl)(Cl)Cl,,,,val
US04859231,CC(=O)n1nc(S(=O)(=O)Cl)nc1N.Nc1c(Cl)cccc1Cl>>CC(=O)n1nc(S(=O)(=O)Nc2c(Cl)cccc2Cl)nc1N,,c1ccncc1,,,,val
US20080261969A1,CC(C)(C)[Si](C)(C)Oc1ccc(N)c(N)c1.S=C(n1ccnc1)n1ccnc1>>CC(C)(C)[Si](C)(C)Oc1ccc2nc(S)[nH]c2c1,,C1CCOC1,,,,val
US06458781B1,C=O.CC(C)C[C@H](NC(C)C)C(=O)O>>CC(C)CC(C(=O)O)N(C)C(C)C,[Pd],CCO,,[H][H],,val
US20060205718A1,CCOC(=O)c1cc(OCC)c(NC(C)=O)c(OCC)c1.O=[Mn]=O>>CCOc1cc(C=O)cc(OCC)c1-n1c(=O)c1=O,O=[Mn]=O,,,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20060211693A1,CCOc1cc(S(=O)(=O)Cl)ccc1C(=O)OC.CNC>>CCOc1cc(S(=O)(=O)N(C)C)ccc1C(=O)OC,,ClCCl,,,,val
US20070099909A1,Cc1ccc(O)cc1[N+](=O)[O-].OB(O)c1ccccc1>>Cc1ccc(Oc2ccccc2)cc1[N+](=O)[O-],,ClCCl,,CCN(CC)CC,,val
US04239901,CCOC(=O)C(C)C(=O)OCC.O=[N+]([O-])c1cc(Cl)c(Cl)cc1Cl>>CCOC(=O)C(Cc1cc(Cl)c([N+](=O)[O-])cc1Cl)C(=O)OCC,,CN(C)C=O,,[H][H],[H-].[Na+],val
US20040102450A1,CCOC(=O)COc1cccs1.O=C1CCC(=O)N1Cl>>O=C(O)COc1ccc(Cl)s1,,CC(=O)O,,,,val
US05939432,O=C(OCc1ccccc1)N1CCC2(CC1)OCCO2>>O=C1CCN(C(=O)OCc2ccccc2)CC1,,C1CCOC1,,Cl,,val
US04788206,CCCCC/C(=C\C=O)c1ccc(OC)cc1.COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCC/C(=C\C=C\C(=O)OC)c1ccc(OC)cc1,,ClC(Cl)(Cl)Cl,,,,val
US20050158804A1,CC(=O)Oc1ccc2c(c1)OC1=CC(OC(C)=O)C=CC1=C2c1ccc(C(=O)O)cc1C(=O)O.NCC(=O)SCc1ccccc1>>O=C(CNC(=O)c1ccc(C2=C3C=CC(O)C=C3Oc3cc(O)ccc32)c(C(=O)O)c1)SCc1ccccc1,,C1CCOC1,CN(C)C=O,ClCCCl,On1nnc2ccccc21,val
US20080113073A1,COc1cc(CC(=O)O)ccc1O.COc1cccc(O)c1>>COc1ccc(C(=O)Cc2ccc(O)c(OC)c2)c(O)c1,,CCOCC,,CC(=O)[O-].[Na+],,val
US20100093781A1,CCOC(=O)c1cccn2cc(C(C)(C)C)nc12>>CC(C)(C)c1cn2cccc(CO)c2n1,,ClC(Cl)(Cl)Cl,,,,val
US20060241100A1,CC(C)(C)OC(=O)N1C2=C(CNCCC2=O)C(c2ccc(C(F)(F)F)cc2)N1c1ccccc1Cl.[NH4+]>>CC(C)(C)OC(=O)N1CCC(N)c2nn(-c3ccccc3Cl)c(-c3ccc(C(F)(F)F)cc3)c2C1,,CO,,[BH3-]C#N.[Na+],,val
US20080051395A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc4c(c3)OCCO4)n2)c1)c1ccccc1>>S=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc4c(c3)OCCO4)n2)c1)c1ccccc1,,C1COCCO1,,,,val
US05028601,BrC(c1ccccc1)c1ccccc1.COc1ccc(COc2cn(O)c(CO)cc2=O)cc1>>COc1ccc(COc2cn(OC(c3ccccc3)c3ccccc3)c(CO)cc2=O)cc1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US04230850,COc1cc(C(=O)Cl)cc(OC)c1OC.O=c1oc2ccccc2c(OCC(O)CN2CCOCC2)c1-c1ccccc1>>COc1cc(C(=O)OC(COc2c(-c3ccccc3)c(=O)oc3ccccc23)CN2CCOCC2)cc(OC)c1OC,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US20050209274A1,CI.O=C1CCN(Cc2ccc3c(c2)OCO3)CC1>>CC1CN(Cc2ccc3c(c2)OCO3)CCC1=O,,C1CCOC1,ClCCl,CC(C)[N-]C(C)C.[Li+],,val
US04882351,COC(=O)c1ccc2c(c1)C(SCCN)c1ccccc1CO2.O=C=Nc1ccccc1>>COC(=O)c1ccc2c(c1)C(SCCNC(=O)Nc1ccccc1)c1ccccc1CO2,,ClCCl,,,,val
US20130261133A1,C=C[C@@H](C#CC#C[C@H](N)CCCCCCCCC)OC(C)=O.CS(=O)(=O)Cl>>C=C[C@@H](C#CC#C[C@@H](CCCCCCCCC)NS(C)(=O)=O)OC(C)=O,,ClCCl,,CCN(CC)CC,,val
US20090240052A1,CC(C)(C)OC(=O)c1ccc(CCc2ccccc2)cc1N.O=C(Cl)c1ccco1>>CC(C)(C)OC(=O)c1ccc(CCc2ccccc2)cc1NC(=O)c1ccco1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20030027840A1,CCCCC12Cc3cc(OCOC)ccc3C1=C(C)C(=O)C(CC(=O)CO)C2>>CCCCC12Cc3cc(O)ccc3C1=C(C)C(=O)C(CC(=O)CO)C2,,CO,,Cl,,val
US20120202856A1,CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2C(F)(F)F)cc1NC(=O)OC(C)(C)C>>Nc1ccc(-c2ccccc2C(F)(F)F)cc1N,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120302610A1,CC(C)(C)OC(=O)CCNC(=O)c1ccc(-c2ccccc2C=O)cn1.Nc1ccc(-c2ccc(Cl)cc2)cc1>>CC(C)(C)OC(=O)CCNC(=O)c1ccc(-c2ccccc2CNc2ccc(-c3ccc(Cl)cc3)cc2)cn1,,C1CCOC1,CCOC(C)=O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150175628A1,Cc1ncc2oc(-c3ccc(N=C=S)cc3)nn12.N>>Cc1ncc2oc(-c3ccc(NC(N)=S)cc3)nn12,,CO,,,,val
US20080188454A1,CC1(C)COC2(CCCC(=O)CCC2)OC1.Cn1cc([N+](=O)[O-])cc([N+](=O)[O-])c1=O>>CC1(C)COC2(CCCc3ncc([N+](=O)[O-])cc3CC2)OC1,,CO,,N,,val
US20150291558A1,COc1c(I)ccnc1F.C[C@@H]1CC[C@@H](O)CN1C(=O)OC(C)(C)C>>COc1c(I)ccnc1O[C@@H]1CC[C@@H](C)N(C(=O)OC(C)(C)C)C1,,CS(C)=O,,[H-].[Na+],,val
US05968954,NO.O=C1CCN(c2cccc3c2OCCC3)CC1>>ON=C1CCN(c2cccc3c2OCCC3)CC1,,CCO,,Cl,CC(=O)[O-].[Na+],val
US05366982,CC(C)=O.CCOC(=O)CCCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1>>CCOC(=O)CCCCCOc1cc(-c2ccc(NC(C)C)cc2)cc(-c2ccccc2)n1,,CC(=O)O,O,[BH4-].[Na+],,val
US06162824,CCCc1ccsc1C1(O)c2ccccc2-c2ccccc21.COC(=O)[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)[C@@H](C)O>>CCCc1ccsc1C1(O[C@H](C)[C@H](N)C(=O)O)c2ccccc2-c2ccccc21,O=C(O)C(F)(F)F,,,O=S(=O)(O)O,,val
US03932407,BrBr.O=C1CN2Cc3c(Cl)cccc3N=C2N1>>O=C1CN2Cc3c(ccc(Br)c3Cl)N=C2N1,,C[N+](=O)[O-],,,,val
US20160108039A1,CC1(CC=O)OCC(C)(C)N(Cc2ccccc2)C1=O>>CC1(CCO)OCC(C)(C)N(Cc2ccccc2)C1=O,,CO,,O,[BH4-].[Na+],val
US20100048543A1,Nc1cccc(C#Cc2cnc(N)nc2)c1.O=C(Cl)Oc1ccccc1>>Nc1ncc(C#Cc2cccc(NC(=O)Oc3ccccc3)c2)cn1,,C1CCOC1,,c1ccncc1,,val
US20070225372A1,Brc1ccccn1.O=C[C@H](Cc1ccccc1)N(Cc1ccccc1)Cc1ccccc1>>O[C@H](c1ccccn1)[C@H](Cc1ccccc1)N(Cc1ccccc1)Cc1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20100310512A1,CC(C)(C)OC(=O)N1CC(C#N)CC1C(=O)NCC(=O)c1ccc(Br)cc1.N>>CC(C)(C)OC(=O)N1CC(C#N)CC1c1ncc(-c2ccc(Br)cc2)[nH]1,,Cc1ccccc1C,,CC(=O)O,,val
US04775674,COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1>>O=C(O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1,,CO,,Cl,,val
US20080261977A1,FC(F)(F)c1nc(Nc2cccc(Cl)c2)ncc1CBr.N>>NCc1cnc(Nc2cccc(Cl)c2)nc1C(F)(F)F,,C1CCOC1,,,,val
US20090275567A1,Cc1ncc(-c2ccnc(NC3CCN(C(=O)C4CN(C(=O)OC(C)(C)C)CCO4)CC3)n2)n1C(C)C>>Cc1ncc(-c2ccnc(NC3CCN(C(=O)C4CNCCO4)CC3)n2)n1C(C)C,,C1COCCO1,ClCCl,Cl,[Na+].[OH-],val
US20080194633A1,CCc1ccc(N=C=O)cc1.Cc1c(F)cccc1CNC(=O)C1(CO)CCN(C(=O)CNC(=O)OC(C)(C)C)CC1>>CCc1ccc(NC(=O)OCC2(C(=O)NCc3cccc(F)c3C)CCN(C(=O)CNC(=O)OC(C)(C)C)CC2)cc1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20120184542A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCC(O)C1CCCCC1>>CC(C)(C)OC(=O)NCCC(O)C1CCCCC1,,C1CCOC1,,,,val
US20060178532A1,CC(C)N(NC(=O)c1ccccc1)C(=O)COc1ccc(F)cc1Br.Cc1cccc(B(O)O)c1C>>Cc1cccc(-c2cc(F)ccc2OCC(=O)N(NC(=O)c2ccccc2)C(C)C)c1C,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20060229348A1,CC(C)(C)OC(=O)NC[C@H](O)CNc1ccc2c(c1)CC(=O)N2C1CC1.O=C(Cl)Cl>>CC(C)(C)OC(=O)NC[C@H]1CN(c2ccc3c(c2)CC(=O)N3C2CC2)C(=O)O1,,ClCCl,,CCN(CC)CC,,val
US04001336,CCC(C)C=CCC(C)C=CCC(C)C=O>>CCC(C)CCCC(C)CCCC(C)C=O,[Pd],C1CCOC1,,,,val
US20040122063A1,CC(C)(C)OC(=O)N[C@H]1CC[C@@H](C(=O)OCc2ccccc2)C[C@H]1N=[N+]=[N-]>>CC(C)(C)OC(=O)N[C@H]1CC[C@@H](C(=O)O)C[C@H]1N=[N+]=[N-],,C1CCOC1,O,[Li+].[OH-],,val
US04963448,CCCCCCc1ccc(N=Nc2ccc(O)cc2)cc1.O=C(CCCCCBr)OC1CCCCO1>>CCCCCCc1ccc(N=Nc2ccc(OCCCCCC(=O)O)cc2)cc1,,CC(=O)N(C)C,O,[Na],C[O-].[Na+],val
US04814425,CC(C)(C#N)N=NC(C)(C)C#N.CC(C)=O.O=C1C=CC(=O)O1.O=C1CCCCC1>>C=C(C)CCOC.COCC=C(C)C,,CC(C)=O,,,,val
US20020095036A1,CNC(=O)n1cnc(C(=O)NC(C)(C)C)c1N>>CC(C)(C)NC(=O)c1nc[nH]c1N,,CCN(CC)CC,,CO,,val
US20040171881A1,CCCCn1ccc2c(C#N)cc(C(=O)O)cc21.CCc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1>>CCCCn1ccc2c(C#N)cc(C(=O)N[C@@H](Cc3cc(F)cc(F)c3)[C@H](O)CNCc3cccc(CC)c3)cc21,,ClCCl,,CCN(CC)CC,,val
US04147872,C1CCOC1.CC(C)(C#N)c1cccc(OCc2ccccc2)c1>>CC(C)(C=O)c1cccc(OCc2ccccc2)c1,,CCCCCC,,CC(C)C[Al+]CC(C)C.[H-],,val
US20060094707A1,CC(C)(C)OC(=O)N1CCC(C2(O)CC(c3ccccc3)=NO2)CC1>>CC(C)(C)OC(=O)N1CCC(c2cc(-c3ccccc3)no2)CC1,,CO,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100130469A1,CC(=O)Cl.CC(C)(N)CNc1nc(-c2ccncc2)cc2cnccc12>>CC(=O)NC(C)(C)CNc1nc(-c2ccncc2)cc2cnccc12,,ClCCl,,c1ccncc1,,val
US20120041030A1,CCCCCS.Cc1c[n+]([O-])ccc1Cl>>CCCCCSc1cc[n+]([O-])cc1C,,CCO,,[Na+].[OH-],,val
US20020107272A1,CC(C)N=C=O.CNCC(=O)O>>CC(C)NC(=O)N(C)CC(=O)O,,O,,[Na+].[OH-],,val
US05728829,C[Si](C)(C)CCOCn1nccc1C(=O)c1ccccc1[N+](=O)[O-]>>C[Si](C)(C)CCOCn1nccc1C(=O)c1ccccc1N,,C1CCOC1,,,,val
US05162316,CCCOc1ccccc1-c1nc2nc(SC)ncc2c(=O)[nH]1.NN>>CCCOc1ccccc1-c1nc2nc(NN)ncc2c(=O)[nH]1,,CCO,,O,,val
US20050250836A1,COCCCn1ccc2c1CC(c1ccccc1Cl)C1C(=O)NC(=O)C21>>COCCCn1ccc2c3c(c(-c4ccccc4Cl)cc21)C(=O)NC3=O,O=[Mn]=O,C1COCCO1,,,,val
US20120238549A1,CC[C@@]12CCC(=O)C[C@@H]1CCCc1cc(O)ccc12.CC[C@]12CCC(=O)C[C@H]1CCCc1cc(O)ccc12.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC[C@@]12CCC(=O)C[C@@H]1CCCc1cc(OS(=O)(=O)C(F)(F)F)ccc12.CC[C@]12CCC(=O)C[C@H]1CCCc1cc(OS(=O)(=O)C(F)(F)F)ccc12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05990107,CCC(Oc1ccc([N+](=O)[O-])cc1OC)C(=O)O>>CCC(Oc1ccc(N)cc1OC)C(=O)O,[Pd],CCO,,,,val
US20110028467A1,Cc1ccc([N+](=O)[O-])c(O)n1>>Cc1ccc(N)c(O)n1,[Pd],CO,ClCCl,[H][H],,val
US20020002182A1,COC(=O)[C@H]1C[C@H]1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)[C@H]1C[C@H]1C(=O)O,,CO,,[K+].[OH-],,val
US20130005759A1,CCOC(=O)Cl.c1ccc2c(c1)CCCN2>>COC(=O)N1CCCc2ccccc21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20070010573A1,CC(C)C(C)N.O=S1(=O)CCCO1>>CC(C)C(C)NCCCS(=O)(=O)O,,C1CCOC1,C1CCOC1,,,val
US05302720,N#CNc1ccccc1-c1cccc(F)c1.OC1CCNCC1>>N=C(Nc1ccccc1-c1cccc(F)c1)N1CCC(O)CC1,,COCCOC,,,,val
US20100168154A1,Cc1cccc(CC#N)c1C(=O)c1ccccc1.Cl>>Cc1cccc2c1C(C1CCCCC1)=NCC2.Cl,O=[Pt],CCO,,CCOC(C)=O,,val
US20150225439A1,Cc1ccc(S(=O)(=O)OCCOCCNC(=O)OC(C)(C)C)cc1.NCCOCCO>>CC(C)(C)OC(=O)NCCOCCNCCOCCO,,CC#N,,,,val
US03947466,O=C(c1ccccc1Cl)c1cc(F)ccc1-n1c(CN2C(=O)c3ccccc3C2=O)nnc1CN1C(=O)c2ccccc2C1=O>>NCc1nnc2n1-c1ccc(F)cc1C(c1ccccc1Cl)=NC2,,CCO,,NN,O,val
US20080261920A1,CC[C@@H](CI)c1ccccc1.COC1=N[C@H](C(C)C)C(OC)=NC1C>>CC[C@@H](C[C@@H]1N=C(OC)[C@@H](C(C)C)N=C1OC)c1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20070219186A1,CSC(=CC#N)N1CCN(C)CC1.NN>>CN1CCN(c2cc(N)[nH]n2)CC1,,CCO,,,,val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.Cc1ccc(O)c(C)c1>>COc1cc2nccc(Oc3ccc(C)cc3C)c2cc1OC,,COCCOCCOC,,[Na+].[OH-],,val
US20140093453A1,CCN(CCO)CCN1C(=O)c2ccccc2C1=O.O=[N+]([O-])c1ncccc1O>>CCN(CCOc1cccnc1[N+](=O)[O-])CCN1C(=O)c2ccccc2C1=O,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070173508A1,COC(C)(OC)OC.NNc1cc(-c2ccccc2)c2ccc(I)cc2n1>>Cc1nnc2cc(-c3ccccc3)c3ccc(I)cc3n12,,CCO,,,,val
US20140045746A1,CCOC(=O)CBr.Oc1cc(C(F)(F)F)ccn1>>CCOC(=O)COc1cc(C(F)(F)F)ccn1,,Cc1ccccc1,,,,val
US20150232465A1,CC(=O)N1c2ccc(B3OC(C)(C)C(C)(C)O3)cc2NC[C@@H]1C.O=C(Cl)c1ccco1>>CC(=O)N1c2ccc(B3OC(C)(C)C(C)(C)O3)cc2N(C(=O)c2ccco2)C[C@@H]1C,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20110160187A1,CCO.COc1ccc(Cl)nn1.Cc1ccccc1>>COc1ccc(-c2c(C)cccc2C)nn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20120071460A1,CCC(=O)CC(=O)OC.NC(=NO)c1cc(F)ccc1F>>CCC(=O)Cc1nc(-c2cc(F)ccc2F)no1,,CC#N,Cc1ccccc1,ClCCl,O,val
US20050235428A1,CC(C)c1cccc(C(=O)O)c1O.NC(=O)c1ccccc1O>>CC(C)c1cccc2c(=O)nc(-c3ccccc3O)oc12,,Cc1ccccc1C,,O=S(Cl)Cl,c1ccncc1,val
US04060633,CC(O)(CCC#N)c1ccc(Oc2ccccc2)cc1.ClCl>>CC(O)(CCC#N)c1ccc(Oc2ccc(Cl)cc2)cc1,,CC(=O)O,,,,val
US20160083400A1,O=c1[nH]c(NC(CCO)c2cccc(Cl)c2)nc2c(C3CCCC3)onc12>>O=C1c2noc(C3CCCC3)c2NC2=NC(c3cccc(Cl)c3)CCN12,,ClCCl,,CS(=O)(=O)Cl,,val
US04814343,CCCC[Mg]Br.O=Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CCCCC(O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,,C1CCOC1,,O,[Cl-].[NH4+],val
US20090062342A1,CS(=O)(=O)OCCOc1ccc(Br)cc1.Cc1cc(Cl)c(O)c(Cl)c1>>Cc1cc(Cl)c(OCCOc2ccc(Br)cc2)c(Cl)c1,,CCCO,O,O=C([O-])[O-].[K+].[K+],,val
US20090312338A1,CC1CCN(C(=O)OC(C)(C)C)CC1C(=O)O.O=C(OCC1c2ccccc2-c2ccccc21)ON1C(=O)CCC1=O>>CC1CCN(C(=O)OCC2c3ccccc3-c3ccccc32)CC1C(=O)O,,C1COCCO1,O,Cl,O=C([O-])O.[Na+],val
US20040147543A1,CCOCc1nc2c(N)nc3cc(-c4cccnc4)ccc3c2n1CC1COC(C)(C)O1>>CCOCc1nc2c(N)nc3cc(-c4cccnc4)ccc3c2n1CC(O)CO,,C1CCOC1,,Cl,,val
US20090124624A1,CN1CCC(O)CC1.O=Cc1ccc(O)cc1>>CN1CCC(Oc2ccc(C=O)cc2)CC1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20010056179A1,NC1(C(=O)O)CCc2c(Cl)cccc2C1.O=C(OCC1c2ccccc2-c2ccccc21)ON1C(=O)CCC1=O>>NC1(C(=O)O)CCc2c(Cl)cccc2C1C(=O)OCC1c2ccccc2-c2ccccc21,,CC#N,O,CCN(CC)CC,,val
US20160102107A1,Cc1cc([N+](=O)[O-])cn2c(C(F)F)nnc12>>Cc1cc(N)cn2c(C(F)F)nnc12,[Pd],CO,,,,val
US20060173043A1,C=CCN(Cc1ccccc1)C(=O)C(=C)CC(=O)OC>>COC(=O)CC1=CCN(Cc2ccccc2)C1=O,[Ru],ClCCl,,,,val
US20070066607A1,NC1(Cc2ccccc2)Cc2ccccc2C1=O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(NC1(Cc2ccccc2)Cc2ccccc2C1=O)C(F)(F)F,,C1CCOC1,,CCN(CC)CC,Cl,val
US20130274268A1,CI.Clc1ncnc2c(Br)c[nH]c12>>Cn1cc(Br)c2ncnc(Cl)c21,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20050043346A1,CC(O)c1ccncc1F>>CC(=O)c1ccncc1F,O=[Mn]=O,Cc1ccccc1,,,,val
US05891893,CCOC(=O)Cl.Cc1ccc(C(N)=NO)c(C)c1>>Cc1ccc(-c2noc(Cl)n2)c(C)c1,,Cc1ccccc1,,c1ccncc1,,val
US20130237502A1,CC1(C)O[C@H](c2ccc(-c3ccc(COS(C)(=O)=O)nc3)cc2)[C@@H](CF)N1C(=O)C(F)F.NCCCF>>CC1(C)O[C@H](c2ccc(-c3ccc(CNCCCF)nc3)cc2)[C@@H](CF)N1C(=O)C(F)F,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20010021714A1,CC(=O)OCCc1cc2c(cc1[N+](=O)[O-])OCO2>>CC(=O)OCCc1cc2c(cc1N)OCO2,[Pd],CCOC(C)=O,,,,val
US05189054,CCOC(=O)c1[nH]c2cc(Cl)c(Cl)cc2c1N.ClCCl.O=C(Cl)c1ccccc1>>CCOC(=O)c1[nH]c2cc(Cl)c(Cl)cc2c1NCC(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20060040918A1,CC(C)(C)OC(=O)N1CCc2ccc(Oc3cnc(C(=O)O)cn3)cc2CC1.CN>>CNC(=O)c1cnc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)CC3)cn1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20050119429A1,CC(C)C=O.Cc1cc(C)c(N)c(C)c1>>Cc1cc(C)c(N=CC(C)C)c(C)c1,,O=CO,,CO,,val
US05696272,CCCCC(=N)NCC(=O)O.CN(C)C=O.O=P(Cl)(Cl)Cl>>CCCCc1nc(C=O)c(Cl)[nH]1,,CCOC(C)=O,O,Cc1ccccc1,[Na+].[OH-],val
US20100249120A1,COc1ccc(Cn2nc(-c3cccc(N)c3)c3c4c(cnc32)C(=O)N(CCc2ccccc2)C4=O)cc1.O=C(Cl)c1ccccc1>>COc1ccc(Cn2nc(-c3cccc(NC(=O)c4ccccc4)c3)c3c4c(cnc32)C(=O)N(CCc2ccccc2)C4=O)cc1,,ClCCl,,CCN(CC)CC,,val
US20050070508A1,Clc1ccnc(Cl)n1.O=C(NCCN1CCOCC1)c1cccc2cc(O)ccc12>>O=C(NCCN1CCOCC1)c1cccc2cc(Oc3ccnc(Cl)n3)ccc12,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20110207729A1,CI.COC(=O)c1ccc2sc(CO)cc2c1>>COCc1cc2cc(C(=O)OC)ccc2s1,,Cl,,C1CCOC1,[H-].[Na+],val
US20160024097A1,CSC(=CC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)SC.N#CCC(N)=O>>CSC1=CC(c2ccc(NC(=O)OC(C)(C)C)cc2)=NC(=O)C1C#N,,CC(C)O,O,Cl,[H-].[Na+],val
US20080085890A1,COCOc1cc(C#N)ccc1I.OB(O)c1ccoc1>>COCOc1cc(C#N)ccc1-c1ccoc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130237525A1,BrC(Br)(Br)Br.OCc1ccnc(OC(F)F)c1>>FC(F)Oc1cc(CBr)ccn1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20020037888A1,N#Cc1ccc(Cn2ccnc2)cc1F.O=C1CCCCN1c1ccccc1O>>N#Cc1ccc(Cn2ccnc2)cc1Oc1ccccc1N1CCCCC1=O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060111370A1,CC(C)(C)OC(=O)N1S(=O)OCC1(C)c1cccc(Br)c1.O>>CC(C)(C)OC(=O)N1C(C)(c2cccc(Br)c2)COS1(=O)=O,,CC#N,,,,val
US20070106080A1,FC(F)(F)C(Cl)=Nc1ccccc1.[N-]=[N+]=[N-]>>FC(F)(F)c1nnnn1-c1ccccc1,,Cc1ccccc1,,CCN(CC)CC,Cl,val
US04897401,CN=C=O.Cc1ccc(Cn2c(NC3CCN(CCN)CC3)nc3ccccc32)o1>>CNC(=O)NCCN1CCC(Nc2nc3ccccc3n2Cc2ccc(C)o2)CC1,,C1CCOC1,,,,val
US20040039061A1,COc1c(C)c(Cc2cccc(C(=O)O)c2-c2ccncc2)c(OC)c(OC)c1OC.Nc1ccc(C(F)(F)F)cc1>>COc1c(C)c(Cc2cccc(C(=O)Nc3ccc(C(F)(F)F)cc3)c2-c2ccncc2)c(OC)c(OC)c1OC,,ClCCl,,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US04076913,O=C(C=Cc1ccccc1)N(c1ccccc1)c1ccccc1.O=S(=O)(O)O>>O=C(O)C=Cc1ccccc1,,O,,CC(=O)O,,val
US20020143017A1,Clc1ccc(OCc2ccccc2)nn1.NC(N)=S>>Sc1ccc(OCc2ccccc2)nn1,,CCC(C)=O,,,,val
US20080096918A1,COc1ccc(CC2COS(=O)(=O)N2C(C(=O)OC(C)(C)C)C(C)C)cc1.NCc1ccccc1>>COc1ccc(CC(CNCc2ccccc2)NC(C(=O)OC(C)(C)C)C(C)C)cc1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100029650A1,CC(C)c1noc(C(Cl)(Cl)Cl)n1.C[C@@H](O)C1CCNCC1>>CC(C)c1noc(N2CCC([C@@H](C)O)CC2)n1,,CO,,[Na+].[OH-],,val
US03940259,Cc1cccc(C)c1N.ClCC1OCCO1>>Cc1cccc(C)c1NCC1OCCO1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030216356A1,CI.N#Cc1c(N)[nH]c2ccc(OCc3ccccc3)cc12>>Cn1c(N)c(C#N)c2cc(OCc3ccccc3)ccc21,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20120309735A1,Brc1nccs1.CCOC(=O)C1CCNCC1>>CCOC(=O)C1CCN(c2nccs2)CC1,,ClCCl,,,,val
US20110144106A1,O=C(OCN1C(=O)C2(CC2c2ccc(Cl)cc2)c2ccccc21)c1ccccc1>>O=C(O)c1cccc(CN2C(=O)[C@]3(C[C@@H]3c3ccc(Cl)cc3)c3ccccc32)c1,,CO,,O,[Li+].[OH-],val
US20040142981A1,Nc1ccc(Br)cc1-c1noc(=O)[nH]1.O=C(O)c1cccc(SCc2ccccc2)c1>>O=C(Nc1ccc(Br)cc1-c1noc(=O)[nH]1)c1cccc(SCc2ccccc2)c1,,ClCCl,c1ccncc1,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20080227797A1,CC(C)(C)OC(=O)N1CCC(NC(=O)c2cc(F)cnc2Nc2ccc(F)c(F)c2)CC1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)N1CCC(n2c(=O)c3cc(F)cnc3n(-c3ccc(F)c(F)c3)c2=O)CC1,,CN1CCCC1=O,,O,[H-].[Na+],val
US06252084B1,CCCCCCCCn1c(C)c(CC(=O)NN)c2cc(OC)ccc21>>CCCCCCCCn1c(C)c(CC(N)=O)c2cc(OC)ccc21,[Ni],CCO,,,,val
US05741795,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)[Si](O[C@@H]1C=C2NC[C@H]3[C@@H]4CC(=O)C[C@@]4(C)CC[C@@H]3[C@@]2(C)CC1)(C(C)C)C(C)C>>CC(C)[Si](O[C@@H]1C=C2N(C(=O)OC(C)(C)C)C[C@H]3[C@@H]4CC(=O)C[C@@]4(C)CC[C@@H]3[C@@]2(C)CC1)(C(C)C)C(C)C,,c1ccncc1,,N#N,,val
US04499296,C#CCBr.CC(=O)CCC1CC1>>C#CCC(C)(O)CCC1CC1,,C1CCOC1,CCOCC,Cl,[Mg],val
US20060194809A1,CC(=O)O.COc1ccc(Cc2c(C)[nH][nH]c2=O)cc1F>>COc1ccc(Cc2c(O)nn(C(C)=O)c2C)cc1F,,CC(=O)O,,CC(=O)OC(C)=O,,val
US04302464,CCNc1cc(C(CN)(OCC)OCC)ccn1.CCOC(=N)CC>>CCNc1cc(-c2c[nH]c(CC)n2)ccn1,,CCO,,Cl,,val
US04229461,CCC1(C(=O)OC)NCCS1.O=C=Nc1cc(Cl)cc(Cl)c1>>CCC1(C(=O)OC)SCCN1C(=O)Nc1cc(Cl)cc(Cl)c1,,Cc1ccccc1,,,,val
US20050187236A1,CC(C)(O)C1CCN(C(=O)OCc2ccccc2)CC1>>CC(C)(O)C1CCNCC1,[Pd],CO,,,,val
US20150111892A1,O=C=NCC(c1ccccc1)c1ccccc1.O=c1cc[nH]c(=O)[nH]1>>O=C(NCC(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O,,ClCCl,,,,val
US20100317620A1,NO.O=Cc1ccc2nc(C(=O)Nc3ccccc3)cn2c1>>O=C(Nc1ccccc1)c1cn2cc(/C=N/O)ccc2n1,,c1ccncc1,,Cl,,val
US20150111889A1,CCOC(=O)OCC.N=C(NO)C1Oc2ccc(Cl)cc2C(C2CCCCC2)(C2CCCCC2)O1>>O=c1[nH]c(C2Oc3ccc(Cl)cc3C(C3CCCCC3)(C3CCCCC3)O2)no1,,CCO,,C[O-].[Na+],,val
US04402960,COc1ccc(-c2nc(Sc3nccs3)[nH]c2-c2ccc(OC)cc2)cc1.O=C(OO)c1cccc(Cl)c1>>COc1ccc(-c2nc(S(=O)c3nccs3)[nH]c2-c2ccc(OC)cc2)cc1,,ClCCl,,,,val
US20070265332A1,Fc1ccc(C(F)(F)F)cc1Cl.O=C1CCc2ccc(O)cc21>>O=C1CCc2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc21,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070275952A1,CC(C)(C)OC(=O)N1CCNCC1.ClC1C=NC=CN1Cl>>CC(C)(C)OC(=O)N1CCN(c2nccnc2Cl)CC1,,O,,CN(C)C=O,,val
US20140088124A1,COC(=O)CC1C[C@H]2CC3(C[C@H]2C1)OCCO3>>COC(=O)CC1C[C@@H]2CC(=O)C[C@@H]2C1,,C1CCOC1,,Cl,,val
US20130225679A1,CN(C)CC1C2CCC(C2)CC1(O)c1cc(O)ccc1F.C[Si](C)(C)Cl>>CN(C)CC1C2CCC(C2)CC1(O)c1cc(O)ccc1F.Cl,,CCC(C)=O,,O,,val
US20060258740A1,CC(C)N(NC(=O)c1ccccc1)C(=O)CCc1ccccc1Br.Cc1cc(F)ccc1B(O)O>>Cc1cc(F)ccc1-c1ccccc1CCC(=O)N(NC(=O)c1ccccc1)C(C)C,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20060079685A1,C=CCOc1ccc([N+](=O)[O-])c(C(=O)c2ccc(C(C)C)cc2)c1>>C=CCOc1ccc(N)c(C(=O)c2ccc(C(C)C)cc2)c1,[Fe],CC(=O)O,,,,val
US20070249609A1,CCOC(CN)OCC.Cc1c(C(=O)O)ccc2c1nc(C(F)(F)F)n2-c1cnc(NC(=O)c2c(F)cccc2F)cn1>>CCOC(CNC(=O)c1ccc2c(c1)nc(C(F)(F)F)n2-c1cnc(NC(=O)c2c(F)cccc2F)cn1)OCC,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20100029650A1,C[C@@H](O)C1CCNCC1.N#CBr>>C[C@@H](O)C1CCN(C#N)CC1,,CO,ClCCl,CC(=O)O,CC(=O)[O-].[Na+],val
US04954160,C=CCON=C(CC)C1=C(O)C(c2cccc(Cl)c2)C(C)(C)CC1=O.O=C(Cl)c1ccccc1>>C=CCON=C(CC)C1=C(OC(=O)c2ccccc2)C(c2cccc(Cl)c2)C(C)(C)CC1=O,,CC(C)=O,,[Na+].[OH-],,val
US20090186831A1,Cc1ccc(S(=O)(=O)O[C@H]2CN(C(=O)OCc3ccccc3)[C@@H]3[C@@H](O)CO[C@H]23)cc1>>Cc1ccc(S(=O)(=O)O[C@H]2CN[C@@H]3[C@@H](O)CO[C@H]23)cc1,[Pd],CCO,,[H][H],,val
US20120046269A1,COCCBr.NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cccc(O)c4)c3)ncnc12>>COCCOc1cccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20030144283A1,NCCCCn1cnc2c(N)nc3ccccc3c21.O=C(Cl)c1ccccc1>>Nc1nc2ccccc2c2c1ncn2CCCCNC(=O)c1ccccc1,,c1ccncc1,,,,val
US20150218092A1,Cc1cc([N+](=O)[O-])ccc1O.ClCCN1CCCC1>>Cc1cc([N+](=O)[O-])ccc1OCCN1CCCC1,,CC#N,,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20140357858A1,Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=S(=O)(Cl)C1CCCCC1>>O=C1CC(=O)N(c2ccc(NS(=O)(=O)C3CCCCC3)cc2)c2ccc3ccccc3c2N1,,c1ccncc1,,,,val
US20110076292A1,CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(C3CN(C(C)(C)C#N)C3)cc1OCC2.O=S(=O)(O)O>>CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(C3CN(C(C)(C)C(N)=O)C3)cc1OCC2,,O=S(=O)(O)O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20130178540A1,CCCCCCCCN.CSCCC(OC(C)=O)C(=O)O>>CCCCCCCCNC(=O)C(CCSC)OC(C)=O,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20120053173A1,CC(=O)c1oc2ccc(OCc3ccccc3)cc2c1C>>Cc1c(C(C)O)oc2ccc(OCc3ccccc3)cc12,,C1CCOC1,CO,[BH4-].[Na+],,val
US05693658,CCc1cnc(C2=NC(C)(C(C)C)C(=O)N2)c(C(=O)NCCCCCC(=O)OC)c1>>CCc1cnc(C2=NC(C)(C(C)C)C(=O)N2)c(C(=O)NCCCCCC(=O)O)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20120010205A1,Cc1cnc2c(C(F)(F)F)cccc2c1Br.O=C(O)c1cccc(B(O)O)c1>>Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(C(=O)O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20040006062A1,Nc1ccc(I)cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1ccc(I)cc1)C(F)(F)F,,ClCCl,,O,c1ccncc1,val
US20150329523A1,COc1cc(N)cc(SCCN2CCOCC2)c1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)cc1>>COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(C)cc4)c4ccccc34)n2)cc(SCCN2CCOCC2)c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20120208806A1,CC(C)(C)N.CC(C)(C)NCCn1c(Cc2cc3c(cc2I)OCCO3)nc2c(N)nc(F)nc21>>CC(C)CNCCn1c(Cc2cc3c(cc2I)OCCO3)nc2c(N)nc(F)nc21,,CN(C)C=O,,,,val
US20130274243A1,CC(C(=O)OCc1ccccc1)[C@H](NC(=O)OC(C)(C)C)C(=O)O.N#Cc1ccc(-c2ccc(N)c(N)c2)cc1F>>C[C@@H](C(=O)OCc1ccccc1)[C@H](NC(=O)OC(C)(C)C)c1nc2cc(-c3ccc(C#N)c(F)c3)ccc2[nH]1,,CN(C)C=O,O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140080816A1,C=O.NCCN1CC2CCCN2C2=C(F)C=CCC21.O=C(O)C(F)(F)F>>Fc1ccc2c3c1N1CCCC1CN3CCNC2.O=C(O)C(F)(F)F,,CCO,,,,val
US20070010520A1,C#CNC.Cc1ccc(Cl)c(C=O)c1F>>C#CN(C)Cc1c(Cl)ccc(C)c1F,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20110312903A1,CC(C)(C)OC(=O)n1ccc2cc(B3OC(C)(C)C(C)(C)O3)ccc21>>CC(C)(C)OC(=O)n1ccc2cc(B(O)O)ccc21,,CC(C)=O,O,,,val
US20120270863A1,COC(=O)c1cccc2oc(C)nc12.COc1ccc(C=O)cc1OC>>COC(=O)c1cccc2oc(/C=C/c3ccc(OC)c(OC)c3)nc12,,C1CCOC1,CC(C)(C)O,CC(C)(C)[O-].[K+],,val
US05719163,CC(Cc1nc(-c2ccc(F)cc2)c(-c2ccc(S(C)(=O)=O)cc2)o1)C(=O)O.N>>CS(=O)(=O)c1ccc(-c2oc(CCC(N)=O)nc2-c2ccc(F)cc2)cc1,,CO,,,,val
US20110237791A1,COc1nc(C(=O)c2ccc(O[Si](C)(C)C(C)(C)C)cc2)ccc1Cl.O=C1CC[C@H](CS(=O)(=O)c2nc3ccccc3s2)N1>>COc1nc(/C(=C/[C@H]2CCC(=O)N2)c2ccc(O[Si](C)(C)C(C)(C)C)cc2)ccc1Cl,,C1CCOC1,,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20120245161A1,CN1CCCCC1CCCl.COC(=O)c1c[nH]c2ccccc12>>COC(=O)c1cn(CCC2CCCCN2C)c2ccccc12,,CN(C)C=O,,Cl,,val
US20090131458A1,O=C(O)CCC1CCOC1>>OCCCC1CCOC1,,C1CCOC1,,,,val
US04059641,CC(C)=CCCC(C)=CCCC(C=O)=CCCC(C)=CCOC1CCCCO1>>CC(C)=CCC/C(C)=C/CC/C(C=O)=C\CC/C(C)=C/CO,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20120083488A1,CC1(C)c2cc(N3CCC(N4CCOCC4)CC3)ncc2C(=O)c2c1[nH]c1cc(C(N)=O)ccc21>>CC1(C)c2cc(N3CCC(N4CCOCC4)CC3)ncc2C(=O)c2c1[nH]c1cc(C#N)ccc21,,CN(C)C=O,O,O=S(Cl)Cl,,val
US20060094767A1,COCOC[C@](C)(O)Cn1cc([N+](=O)[O-])nc1Cl>>COCOC[C@@]1(C)Cn2cc([N+](=O)[O-])nc2O1,,CN(C)C=O,,[H-].[Na+],,val
US05994378,CNC.COC(=O)Cc1cn(Cc2ccc3oc(-c4nc(C(C)(C)C)cs4)cc3c2)c2ccc(OCC(=O)O)cc12>>COC(=O)Cc1cn(Cc2ccc3oc(-c4nc(C(C)(C)C)cs4)cc3c2)c2ccc(OCC(=O)N(C)C)cc12,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20070021443A1,NCc1cccnc1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>O=[N+]([O-])c1cnc(Cl)nc1NCc1cccnc1,,ClCCl,,,,val
US20160031876A1,COC(=O)[C@@]1(c2cccc(F)c2C)CC[C@@H](O)C1>>COC(=O)[C@]1(c2cccc(F)c2C)CCC(=O)C1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20120094982A1,CC(=O)OC(C)=O.CN1C(=O)C(Cc2ccc3ccccc3c2)N=C(N2CCC(N)CC2)c2cc(Cl)ccc21>>CC(=O)NC1CCN(C2=NC(Cc3ccc4ccccc4c3)C(=O)N(C)c3ccc(Cl)cc32)CC1,,CCOC(C)=O,ClCCl,CCN(CC)CC,CO,val
US20140057906A1,C#CC1(C)CC1.Nc1ccc([N+](=O)[O-])cc1Br>>CC1(C#Cc2cc([N+](=O)[O-])ccc2N)CC1,[Cu]I,CCN(CC)CC,,,,val
US05006520,NCCO.O=C(O)COc1cccc(-n2nc(-c3ccc(F)cc3)c3cccnc32)c1>>O=C(COc1cccc(-n2nc(-c3ccc(F)cc3)c3cccnc32)c1)NCCO,,ClC(Cl)Cl,,CCN(CC)CC,CCOC(=O)Cl,val
US20040034005A1,BrC(Br)(Br)Br.O=[N+]([O-])c1cc(Cl)ccc1CCO>>O=[N+]([O-])c1cc(Cl)ccc1CCBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060211724A1,NCCc1ccccc1.O=C1CCC(=O)O1>>O=C1CCC(=O)N1CCc1ccccc1,CN(C)c1ccncc1,CC(=O)O,,,,val
US20060058248A1,COC(=O)c1ccc(Cl)nc1.c1cn[nH]c1>>COC(=O)c1ccc(-n2cccn2)nc1,,CS(C)=O,,[H-].[Na+],[Cl-].[NH4+],val
US20100093706A1,C[C@@H]1CC[C@@H](COc2ccc(C(F)(F)F)cc2)CN1C(=O)OC(C)(C)C>>C[C@@H]1CC[C@@H](COc2ccc(C(F)(F)F)cc2)CN1,,CO,,CCOCC,Cl,val
US20120184508A1,CC(C)(C)OC(=O)NCC(Nc1nccc(-c2n[nH]c3nc(NC4CCC(NC(=O)OC(C)(C)C)CC4)ncc23)n1)c1cccc(Cl)c1>>NCC(Nc1nccc(-c2n[nH]c3nc(NC4CCC(N)CC4)ncc23)n1)c1cccc(Cl)c1,,CO,Cl,,,val
US04851519,CCCC(=O)Cl.CCc1cn([C@H]2C[C@H](O)[C@@H](CNC(=O)Cc3c(Cl)cccc3Cl)O2)c(=O)[nH]c1=O>>CCCC(=O)O[C@H]1C[C@H](n2cc(CC)c(=O)[nH]c2=O)O[C@@H]1CNC(=O)Cc1c(Cl)cccc1Cl,CN(C)c1ccncc1,c1ccncc1,,,,val
US20100016315A1,BrBr.NC(=O)c1cc(Cl)cc(CO)c1>>NC(=O)c1cc(Cl)cc(CBr)c1,,CC#N,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160046635A1,CCCNc1nc(NC)c2nc(Cl)nc(NC)c2n1.OB(O)c1ccc(F)cc1>>CCCNc1nc(NC)c2nc(-c3ccc(F)cc3)nc(NC)c2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US20110130423A1,Cc1cc(NC2CCN(C(=O)OC(C)(C)C)CC2)c(O)cc1F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cc2c(cc1F)oc(=O)n2C1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090247547A1,COC(=O)/C=C/c1ccc([C@H]2CCCN2C(=O)OC(C)(C)C)cc1>>COC(=O)CCc1ccc([C@H]2CCCN2C(=O)OC(C)(C)C)cc1,[Pd],CCO,,,,val
US20110281895A1,C(=C/[C@H]1CCNC1)\c1cncnc1.O=C(O)C(=O)O>>C(=C/[C@H]1CCNC1)\c1cncnc1.O=C(O)C(=O)O,,CCO,,,,val
US05155122,CC(C)(C)c1cc(C(=O)NN)cc(C(C)(C)C)c1O.S=C=S>>CC(C)(C)c1cc(-c2n[nH]c(=S)o2)cc(C(C)(C)C)c1O,,CCO,,[K+].[OH-],,val
US20100087417A1,CCc1cc(-c2noc(-c3cc(C)nc(N(CC)CC)c3)n2)cc(C)c1OCCOS(C)(=O)=O.CN>>CCc1cc(-c2noc(-c3cc(C)nc(N(CC)CC)c3)n2)cc(C)c1OCCNC,,CO,,,,val
US04092311,CC(C)(C)OC(=O)NN.Cc1cc(Cl)nnc1-c1cccc([N+](=O)[O-])c1>>Cc1cc(NNC(=O)OC(C)(C)C)nnc1-c1cccc([N+](=O)[O-])c1,,CCCCO,,,,val
US20120277224A1,C1CCNC1.COc1ccc(Cn2ncc(-c3ccc(F)nc3)c2N)cc1>>COc1ccc(Cn2ncc(-c3ccc(N4CCCC4)nc3)c2N)cc1,,CCCCO,,,,val
US20080064872A1,CCOC=O.O=C(Cc1ccccc1)c1ccccc1>>O=C/C(=C(\O)c1ccccc1)c1ccccc1,,CCO,,C,C[O-].[Na+],val
US06242449B1,CCOC(=O)CCCn1cc(C(=O)c2ccc(N)c(OCCCN3CCN(c4ccccc4OC)CC3)c2)c2ccccc21.ClC(c1ccccc1)c1ccccc1>>CCOC(=O)CCCn1cc(C(=O)c2ccc(NC(c3ccccc3)c3ccccc3)c(OCCCN3CCN(c4ccccc4OC)CC3)c2)c2ccccc21,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US06734193B1,CCN1CCC(C)(C)c2cc(C(C)C)cc(C=O)c21.C[Mg]Br>>CCCN1CCC(C)(C)c2cc(C(C)C)cc(C=O)c21,,C1CCOC1,,,,val
US20160176850A1,CCN.COC(=O)c1cc(N2CCC(c3cnc4ccc(-c5cnn(C)c5)cc4n3)CC2)nc(Cl)n1>>CCNC(=O)c1cc(N2CCC(c3cnc4ccc(-c5cnn(C)c5)cc4n3)CC2)nc(Cl)n1,,CO,,CCN(C(C)C)C(C)C,,val
US20040198980A1,CC(C)Br.Oc1ccc(Br)c2ccccc12>>CC(C)Oc1ccc(Br)c2ccccc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130267510A1,Cc1noc2cccc(Oc3ccc(NC(=O)[C@@H](C)N(C(=O)[O-])C(C)(C)C)cc3)c12>>Cc1noc2cccc(Oc3ccc(NC(=O)[C@@H](C)N)cc3)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US06031111,CCOC(CN1C(=O)C(CC(=O)Nc2ccc(C(=O)OC)cc2)(NC(=O)Nc2ccc(C)cc2)c2ccccc21)OCC>>CCOC(CN1C(=O)C(CC(=O)Nc2ccc(C(=O)O)cc2)(NC(=O)Nc2ccc(C)cc2)c2ccccc21)OCC,,CO,,[K+].[OH-],,val
US20110071314A1,CC(=O)O.O=c1c2cc3c(=O)n(O)c(=O)c3cc2c(=O)n1O>>Cc1ccc(C)c(C)c1,,CC(=O)O,,,,val
US20150183809A1,CC(C)(C)OC(=O)C(O)C(O)C(=O)OC(C)(C)C.CCOP(=O)(Cl)OCC>>CCOP(=O)(OCC)O[C@@H](C(=O)OC(C)(C)C)[C@@H](O)C(=O)OC(C)(C)C,,O,,CCN(CC)CC,ClCCl,val
US04767760,CN1CCNCC1.O=C(Cl)C(c1ccc(Cl)cc1)c1c(Cl)cc(-n2ncc(=O)[nH]c2=O)cc1Cl>>CN1CCN(C(=O)C(c2ccc(Cl)cc2)c2c(Cl)cc(-n3ncc(=O)[nH]c3=O)cc2Cl)CC1,,C1CCOC1,,,,val
US20140045872A1,COc1ccc2c(c1)C(=O)NCC2.Cc1ccncc1I>>COc1ccc2c(c1)C(=O)N(c1cnccc1C)CC2,I[Cu]I,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20090137561A1,COC(=O)c1ccc(-c2cc(OC)ccc2F)c(C2=CCOCC2)c1>>COc1ccc(F)c(-c2ccc(CO)cc2C2=CCOCC2)c1,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20110059943A1,CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(N)nc21.CS(=O)c1nc2cc(F)ccc2s1>>CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3nc4cc(F)ccc4s3)nc21,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20090124609A1,Cn1cc(-c2cc(F)c3nnc(C(F)(F)c4ccc5ncc(OCc6ccccc6)cc5c4)n3c2)cn1>>Cn1cc(-c2cc(F)c3nnc(C(F)(F)c4ccc5ncc(O)cc5c4)n3c2)cn1,,CO,,ClCCl,O=C(O)C(F)(F)F,val
US20120149684A1,Nc1ncnc(Cl)c1CNCC(F)(F)F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C1Nc2ncnc(Cl)c2CN1CC(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20100273764A1,CN(C)C(=O)Cl.COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(C(C)N4CCNCC4)cnc3Nc3ccc4scnc4c3)n2)cc1>>Cc1nc(N)nc(-c2cc(C(C)N3CCN(C(=O)N(C)C)CC3)cnc2Nc2ccc3scnc3c2)n1,,ClCCl,,CCN(CC)CC,,val
US20160235734A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccc(CNC[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(OCc3ccccc3)c3[nH]c(=O)ccc23)cc1>>COC(=O)c1ccc(CN(C[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(OCc3ccccc3)c3[nH]c(=O)ccc23)C(=O)OC(C)(C)C)cc1,,ClCCl,,,,val
US20070027155A1,COc1ncc(Cl)c(N2CCN[C@H](C)C2)n1.Fc1ccc(-c2cc(Cl)nc(Cl)n2)cc1>>C[C@@H]1CN(c2nc(Cl)ncc2Cl)CCN1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040019051A1,Clc1ncccc1OCC1CO1.OCc1ccccc1>>C=C/C=C\CCOCC(O)COc1cccnc1Cl,,O,,C1CCOC1,[Na+].[OH-],val
US20040058904A1,Cc1ccccc1NC(=O)Nc1ccc(CNC(=O)OC(C)(C)C)cc1>>Cc1ccccc1NC(=O)Nc1ccc(CN)cc1,,ClCCl,,,,val
US20080021027A1,CCNCC.O=C(NC1CCCCC1)C(C1CCCCC1)n1c(-c2ccc(Cl)nc2)nc2ccccc21>>CCN(CC)c1ccc(-c2nc3ccccc3n2C(C(=O)NC2CCCCC2)C2CCCCC2)cn1,,CN(C)C=O,,,,val
US04526719,C1COCCN1.C=O.COc1c(O)cc(C)c(O)c1OC>>COc1c(O)c(C)c(CN2CCOCC2)c(O)c1OC,,C1COCCO1,,,,val
US05969139,CC1(C)CC(=O)C2=C(C1)NC1=C(C(=O)CC(C)(C)C1)C2c1cccc([N+](=O)[O-])c1>>CC1(C)CC(=O)C2=C(C1)NC1=C(C(=O)CC(C)(C)C1)C2c1cccc(N)c1,[Pd],CCO,Cl,[H][H],,val
US20060161001A1,Fc1nccc(N2CCCc3ccc(-c4ccccc4)nc32)n1.NCCc1cccnc1>>c1ccc(-c2ccc3c(n2)N(c2ccnc(NCCc4cccnc4)n2)CCC3)cc1,,CN1CCCC1=O,,,,val
US05665754,COC(=O)Cl.COc1ccc(C2CN(Cc3ccccc3)CC2C#N)cc1OC1CCCC1>>COC(=O)N1C[C@@H](c2ccc(OC)c(OC3CCCC3)c2)[C@H](C#N)C1,,CC#N,,,,val
US20120058999A1,CCOC(=O)C1=NCCn2cccc21>>CCOC(=O)C1NCCn2cccc21,,O,,CO,[BH4-].[Na+],val
US20100179168A1,COc1ccc(NC(=O)[C@@H](C)NC(=O)OC(C)(C)C)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1.Cl>>COc1ccc(NC(=O)[C@@H](C)N)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1.Cl,,C1COCCO1,,,,val
US20010027196A1,Cc1ccn(-c2nc(N)nc(S(C)=O)c2C#N)n1.SCCc1ccccn1>>Cc1ccn(-c2nc(N)nc(SCCc3ccccn3)c2C#N)n1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20070054935A1,COc1ccc(F)cc1[Mg]Br.N#Cc1cccc(-c2ccncc2C=O)c1>>COc1ccc(F)cc1C(O)c1cnccc1-c1cccc(C#N)c1,,C1CCOC1,,,,val
US20040157891A1,COc1ccc(-c2nc(C(=O)C3CC3)oc2-c2ccc(OCCO)cc2)cn1.NO>>COc1ccc(-c2nc(/C(=N/O)C3CC3)oc2-c2ccc(OCCO)cc2)cn1,,c1ccncc1,,Cl,,val
US20040082496A1,COC(=O)[C@@H](N)Cc1cn(Cc2cc(Cl)cc(Cl)c2)c2ccccc12>>c1ccc2[nH]ccc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(Oc3ccccc3)cc(C)c21>>Cc1cc(Oc2ccccc2)cc2c1C(CC(=O)O)OB2O,,CO,,Cl,[Li+].[OH-],val
US20030027847A1,CC1(C)OC(=O)/C(=C/C(=O)O[Si](C)(C)C(C)(C)C)O1>>CC1(C)OC(=O)/C(=C/C(=O)O)O1,,C1CCOC1,CCOC(C)=O,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20140171390A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)CC1CCC(NCCNS(C)(=O)=O)CC1>>CCOC(=O)CC1CCC(N(CCNS(C)(=O)=O)C(=O)OC(C)(C)C)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070218560A1,CN(CCN)C(=O)OC(C)(C)C.O=C1CCC(=O)O1>>CN(CCNC(=O)CCC(=O)O)C(=O)OC(C)(C)C,,ClCCl,,,,val
US20110301161A1,CC(C)(C)n1c(-c2ccccc2C(=N)NO)nc2cc(Br)ccc21.CN.O=C(Cl)C(=O)Cl>>CNC(=O)c1nc(-c2ccccc2-c2nc3cc(Br)ccc3n2C(C)(C)C)no1,,C1CCOC1,c1ccncc1,,,val
US05545636,CC(=N)O.CCN(CC)CC.Cc1ccc(S(=O)(=O)O)cc1.FC(F)(F)C(F)(F)C(F)(F)CN1CCC(n2ccc3ccccc32)CC1.O=C(Cl)C(=O)Cl>>Cn1cc(C2=C(c3cn(C4CCN(CC(F)(F)C(F)(F)C(F)(F)F)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21,,CCOCC,ClCCl,Cl,O,val
US06060469,C=CCc1cc([N+](=O)[O-])cc(Br)c1O.CO>>O=[N+]([O-])c1cc(Br)c(O)c(CCO)c1,,ClCCl,,,,val
US20160184285A1,Brc1ccc(CNc2ccccc2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C(c1ccc(Br)cc1)C1CCNCC1>>O=C(c1ccc(Br)cc1)C1CCN(C(=O)NCc2ccc(Br)cc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110039889A1,CCOc1c(F)cc(C(=O)O)cc1F.N=C(NO)c1cccc2cnccc12>>CCOc1c(F)cc(-c2nc(-c3cccc4cnccc34)no2)cc1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060183736A1,COc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3cc(F)c(S(C)(=O)=O)c(F)c3)ccc2c1.Cl>>CS(=O)(=O)c1c(F)cc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1F.Cl,,CCOC(C)=O,CCOCC,BrB(Br)Br,,val
US20030055085A1,N#Cc1cc(F)cc(C(=O)O)c1.O=C(Cl)C(=O)Cl>>N#Cc1cc(F)cc(C(=O)Cl)c1,,CN(C)C=O,,,,val
US20050137193A1,CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.Cn1cc(C(=O)c2cc(Cl)ccc2N)nn1>>Cn1cc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nn1,,c1ccncc1,,,,val
US20100009956A1,CC(C)(C)OC(=O)NN(c1nc(C#N)ncc1Br)C1CCCC1>>N#Cc1ncc(Br)c(N(N)C2CCCC2)n1,,CC#N,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060241302A1,COc1ccc(CNc2cc(C(Sc3ccc(Cl)cc3)c3cc(F)ccc3F)c(Cl)cn2)cc1OC>>Nc1cc(C(Sc2ccc(Cl)cc2)c2cc(F)ccc2F)c(Cl)cn1,,CCCCCC,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US05879894,O=C(C=CCBr)OCc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(CC=C[PH](c1ccccc1)(c1ccccc1)c1ccccc1)OCc1ccccc1.[Br-],,c1ccccc1,,,,val
US20050176689A1,CCOC(=O)C(C)=Cc1ccc(C#Cc2cccc(CN(C)C3CC3)c2)cc1>>CC(=Cc1ccc(C#Cc2cccc(CN(C)C3CC3)c2)cc1)C(=O)O,,C1CCOC1,CCO,[K+].[OH-],,val
US20040186140A1,C=O.CC(C)N[C@@H]1CC[C@H](N2CCC(c3cccc(C(F)(F)F)c3)=CC2=O)[C@H](CS(=O)(=O)c2ccccc2)C1>>CC(C)N(C)[C@@H]1CC[C@H](N2CCC(c3cccc(C(F)(F)F)c3)=CC2=O)[C@H](CS(=O)(=O)c2ccccc2)C1,,CO,,O,[BH3-]C#N.[Na+],val
US20040053908A1,Nc1ccc(Oc2ccnc3[nH]ccc23)cc1.O=C=Nc1ccc(F)cc1>>O=C(Nc1ccc(F)cc1)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1,,CCOC(C)=O,,,,val
US20110082181A1,CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1C(O)CCCc1ccccc1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4C(O)CCCc4ccccc4)cc3)cc2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,,,val
US05158952,CCCCCCCCCC(=O)Cl.Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O.ClCCl>>CCCCCCCCCC(=O)OC1CCCn2c1nc(C)c(CCN1CCC(c3noc4cc(F)ccc34)CC1)c2=O.Cl.Cl,,ClCCl,O,[Na+].[OH-],,val
US05071865,CCC(=O)OC(=O)CC.CNc1nc(Cl)c([N+](=O)[O-])s1>>CCC(=O)N(C)c1nc(Cl)c([N+](=O)[O-])s1,,CCOC(C)=O,Cc1ccccc1,,,val
US20090143424A1,OCCCC#Cc1cc(C#CCCCO)c(C#CCCCO)cc1C#CCCCO>>OCCCCCc1cc(CCCCCO)c(CCCCCO)cc1CCCCCO,[Pd],CO,,,,val
US09150557B1,O=C(O)CCCC[C@@H]1CCSS1.OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCl>>O=C(CCCC[C@@H]1CCSS1)OCCCN1CC(O)C(O)[C@H](O)C1CO,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130184476A1,CCCCC(F)(F)C(O)CC[C@H]1[C@H](OC2CCCCO2)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)OCc1ccccc1>>CCCCC(F)(F)C(=O)CC[C@H]1[C@H](OC2CCCCO2)CC(=O)[C@@H]1C/C=C\CCCC(=O)OCc1ccccc1,,CS(C)=O,,CCN(C(C)C)C(C)C,ClCCl,val
US05776718,CC(C)(C)OC(=O)N[C@@H](CCc1ccccc1)COS(C)(=O)=O.C[Si](C)(C)CCS>>CC(C)(C)OC(=O)N[C@@H](CCc1ccccc1)CSCC[Si](C)(C)C,,C1CCOC1,,CCOC(C)=O,[H-].[Na+],val
US20100210704A1,Cc1sc(F)c(NN)c1C.N#CCC(=O)Cl>>Cc1sc(F)c(-n2nc(O)cc2N)c1C,,C1CCOC1,,,,val
US20160137653A1,COc1ccc(C2CCC(CC(=O)O)CC2)cc1.Nc1ccc(Cl)cc1>>COc1ccc([C@@H]2CC[C@H](CC(=O)Nc3ccc(Cl)cc3)CC2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150080365A1,Cc1nc(N2CCNCC2)no1.O=C(O)/C=C/C(F)(F)C(F)F>>Cc1nc(N2CCN(C(=O)/C=C/C(C)(F)F)CC2)no1,CN(C)C=O,ClCCl,,Cl,O=C(Cl)C(=O)Cl,val
US05250679,Nc1ccc(I)cc1C(=O)O.O=C(Cl)Cl>>O=c1[nH]c2ccc(I)cc2c(=O)o1,,Cc1ccccc1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20050004162A1,CCOC(=O)Cc1coc2cc(Cl)ccc12>>OCCc1coc2cc(Cl)ccc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060276433A1,O=CC=Cc1ccc([N+](=O)[O-])cc1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>O=[N+]([O-])c1ccc(/C=C/c2cnco2)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US04927832,C1CCNC1.ClC1CCCCc2cccnc21>>c1cnc2c(c1)CCCCC2N1CCCC1,,O,,Cl,,val
US04886806,COc1cc(-c2oc3ccccc3c(=O)c2C(=O)O)cc(OC)c1OC.c1ccc(CN2CCNCC2)cc1>>COc1cc(-c2oc3ccccc3c(=O)c2C(=O)N2CCN(Cc3ccccc3)CC2)cc(OC)c1OC,CN(C)c1ccncc1,ClCCl,,CS(=O)(=O)Cl,,val
US20100324023A1,COC(=O)C(Cc1cc(Cl)c2[nH]ncc2c1CCl)NC(=O)OCc1ccccc1.COc1ccc(CN)cc1>>COC(=O)C(Cc1cc(Cl)c2[nH]ncc2c1CNCc1ccc(OC)cc1)NC(=O)OCc1ccccc1,,CC#N,,O=C([O-])O.[Na+],,val
US20100135999A1,CCOC(=O)N1CCN(C(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)c2cc(O)c3ccc(C)cc3n2)CC1.C[C@@H](O)C(=O)OCc1ccccc1>>CCOC(=O)N1CCN(C(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)c2cc(O[C@@H](C)C(=O)OCc3ccccc3)c3ccc(C)cc3n2)CC1,,C1CCOC1,O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130165483A1,CC(=O)Nc1cc(-c2cc(-c3ccccc3C)c(-c3nnc[nH]3)n2COCC[Si](C)(C)C)ccn1>>CC(=O)Nc1cc(-c2cc(-c3ccccc3C)c(-c3nnc[nH]3)[nH]2)ccn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100305084A1,COCc1cc2ccccc2[nH]1.Cn1c(CN2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(Cl)nc21>>COCc1cc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C(C)(C)O)CC3)n(C)c2n1,,CN(C)C=O,O,[H-].[Na+],,val
US04301284,CC(CBr)Cc1ccc(C(C)(C)C)cc1Cl.C[C@H]1CNC[C@@H](C)O1>>CC(Cc1ccc(C(C)(C)C)cc1Cl)CN1C[C@H](C)O[C@H](C)C1,,CC#N,ClCCl,,,val
US20160221959A1,C#C[Si](C)(C)C.O=C1CSC1>>C[Si](C)(C)C#CC1(O)CSC1,,C1CCOC1,,[Li]CCCC,,val
US20100298287A1,COC(=O)c1ccc(Cl)c(N)c1NCCCCO.COc1ccc(N=C=S)c(Cl)c1>>COC(=O)c1ccc(Cl)c(NC(=S)Nc2ccc(OC)cc2Cl)c1NCCCCO,,C1CCOC1,,,,val
US20090054445A1,CS(=O)(=O)Cl.O=C(NC(c1ccccc1)c1ccccn1)c1c(O)c(-c2ccccc2)nc2ccccc12>>CS(=O)(=O)Oc1c(-c2ccccc2)nc2ccccc2c1C(=O)NC(c1ccccc1)c1ccccn1,,ClCCl,,,,val
US20150191478A1,COC(=O)c1ccc(-c2cncc3cc(/C=C4\SC(=O)NC4=O)oc23)cc1>>O=C1NC(=O)/C(=C/c2cc3cncc(-c4ccc(C(=O)O)cc4)c3o2)S1,,C1CCOC1,CO,[Na+].[OH-],,val
US20090306066A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)N(C(=O)OC(C)(C)C)c1nc(Cl)nc(NC2CCC2)c1F>>NN=c1nc(Cl)[nH]c(NC2CCC2)c1F,,C1COCCO1,CO,Cl,,val
US20070004725A1,C1COCCN1.COC(=O)CCc1ccc(Oc2ccc(CC(NC(=O)OC(C)(C)C)C(=O)O)cc2)cc1>>COC(=O)CCc1ccc(Oc2ccc(CC(NC(=O)OC(C)(C)C)C(=O)N3CCOCC3)cc2)cc1,,ClCCl,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20020040020A1,CC(=O)N1CCc2[nH]nc(-c3ccc(Cl)cc3)c2C1.ClCCCBr>>CC(=O)N1CCc2c(c(-c3ccc(Cl)cc3)nn2CCCCl)C1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20080293775A1,CCS(=O)(=O)c1ccc(F)c(Cl)c1.COc1ccc(F)cc1S>>CCS(=O)(=O)c1ccc(Sc2cc(F)ccc2OC)c(Cl)c1,,O,,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US20160009760A1,C1COCCO1.CC(C)(C)C([O-])([O-])[O-].CC(C)(C)OC(=O)NCCCNc1ccc(C(=O)O)cc1N>>Cc1nc2cc(C(=O)O)ccc2n1CCCNC(=O)OC(C)(C)C,,C1COCCO1,,,,val
US20120022107A1,CC(N)c1ccccc1.CCOC(=O)N1CCC(=O)C(OCC2CC2)C1>>CCOC(=O)N1CC[C@H](NC(C)c2ccccc2)[C@H](OCC2CC2)C1,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100113417A1,Br[Mg]c1ccccc1.CC(C)(C)OC(=O)N1CCC2(CC1)CCC(C#N)(N1CC(F)(F)C1)CC2>>CC(C)(C)OC(=O)N1CCC2(CC1)CCC(c1ccccc1)(N1CC(F)(F)C1)CC2,,C1CCOC1,,,,val
US20120208819A1,N#Cc1cnc(F)c(-c2ncco2)c1.NCc1ccc(-c2cn(S(=O)(=O)c3ccccc3)c3ncnc(N)c23)cc1>>N#Cc1cnc(NCc2ccc(-c3cn(S(=O)(=O)c4ccccc4)c4ncnc(N)c34)cc2)c(-c2ncco2)c1,,CS(C)=O,,CCN(CC)CC,O,val
US20070207994A1,Cn1nccc1-c1cc(N)ccc1OCCN1CCCC1.O=C(O)C(O)c1ccc(Cl)cc1>>Cn1nccc1-c1cc(NC(=O)C(O)c2ccc(Cl)cc2)ccc1OCCN1CCCC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070093462A1,CCCCCCCCCC[N+](C)(C)CCCCCCCCCC.O=C([O-])c1ccccc1>>CCCCCCCCCC[N+](C)(C)CCCCCCCCCC.O=C([O-])c1ccccc1,,O,,[Cl-].[Na+],,val
US04707499,CC(C)N.CCC(C#N)(CC1CO1)c1ccccc1>>CCC1(c2ccccc2)CC(CNC(C)C)OC1=N,,CCO,,,,val
US20030225283A1,CS(=O)(=O)c1ccc(C(CC2CCC(=O)C2)C(=O)O)cc1Cl.Nc1cnc(Br)cn1>>CS(=O)(=O)c1ccc(C(CC2CCC(=O)C2)C(=O)Nc2cnc(Br)cn2)cc1Cl,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20080255202A1,CC(C)(C)OC(=O)C(C)(C)Sc1ccc(CN(Cc2ccco2)Cc2cc(-c3ccc(C(F)(F)F)cc3C(F)(F)F)no2)cc1>>CC(C)(Sc1ccc(CN(Cc2ccco2)Cc2cc(-c3ccc(C(F)(F)F)cc3C(F)(F)F)no2)cc1)C(=O)O,,C1COCCO1,Cl,,,val
US20100022502A1,CC(C)(C)OC(=O)N1CC(c2cc(Cl)nc(-c3ccccc3Cl)n2)C1.Cc1cc(N)n[nH]1>>Cc1cc(Nc2cc(C3CNC3)nc(-c3ccccc3Cl)n2)n[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,[I-].[Na+],val
US20060173018A1,O=C(O)CC1CCOCC1.Oc1ccccc1-c1nc(N2CCNCC2)c2cc(F)ccc2n1>>O=C(CC1CCOCC1)N1CCN(c2nc(-c3ccccc3O)nc3ccc(F)cc23)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05266567,C1CCNC1.CCCCCCCCCCCCCCBr>>CCCCCCCCCCCCCCN1CCCC1,,CC#N,,,,val
US07074817B2,Brc1ccc2c(ccn2Cc2ccccc2)c1.OB(O)c1ccc(OC(F)(F)F)cc1>>FC(F)(F)Oc1ccc(-c2ccc3c(ccn3Cc3ccccc3)c2)cc1,,C1COCCO1,O,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20160068489A1,Cc1nc(NC(=O)c2ccc3c(c2)OCO3)c(C)c(C)c1OCc1ccccc1>>Cc1nc(NC(=O)c2ccc3c(c2)OCO3)c(C)c(C)c1O,[Pd],,,CO,,val
US20050049245A1,CN.OC(CCl)c1ccc[nH]1>>CNCC(O)c1ccc[nH]1,,CO,O,[BH4-].[Na+],,val
US20110230461A1,O[C@H]1CCc2cc(Br)ccc21.[N-]=[N+]=NP(=O)(Oc1ccccc1)Oc1ccccc1>>[N-]=[N+]=N[C@@H]1CCc2cc(Br)ccc21,,CCOC(C)=O,Cc1ccccc1,C1CCC2=NCCCN2CC1,,val
US20090081165A1,CCOC(=O)c1ccc2c(c1)nc(-c1ccc(N)c(C=O)c1)n2C1CCCCC1.O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4cc(Br)ccc4O)ccc3c1)n2C1CCCCC1>>O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4cccc5ccccc45)ccc3c1)n2C1CCCCC1,,CCO,,[K+].[OH-],,val
US04761420,COC(=O)C1=C(C)NC(C)=C(C(=O)O)C1c1cccc([N+](=O)[O-])c1.OCCCBr>>COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCBr)C1c1cccc([N+](=O)[O-])c1,,CN(C)C=O,ClCCl,O=S(Cl)Cl,,val
US20160214940A1,C[C@H]1CNC[C@@H](C)O1.NC(=O)c1cn(-c2ccc(F)cc2)c2ccc(C=O)cc2c1=O>>C[C@H]1CN(Cc2ccc3c(c2)c(=O)c(C(N)=O)cn3-c2ccc(F)cc2)C[C@@H](C)O1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20090264445A1,COC(=O)[C@H](CC(C)C)N1CC(Oc2ccc(C[C@H]3COC(C)(C)O3)cc2)=CC1=O>>CC(C)C[C@@H](C(=O)O)N1CC(Oc2ccc(C[C@H]3COC(C)(C)O3)cc2)=CC1=O,,C1CCOC1,O,[Li+].[OH-],,val
US04110465,O=C1N=c2c([N+](=O)[O-])cccc2=C1c1ccccc1>>Nc1cccc2c1=NC(=O)C=2c1ccccc1,[Pd],C1CCOC1,,[H][H],,val
US20150196672A1,O=C(O)c1ccc(-c2ccc(F)cc2)cc1>>OCc1ccc(-c2ccc(F)cc2)cc1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20100197675A1,Oc1ccc(C(O)CNCC23CC4CC(CC(C4)C2)C3)cc1>>OC1CCC(C(O)CNCC23CC4CC(CC(C4)C2)C3)CC1,O=[Pt]=O,CO,,,,val
US04220795,CCC1CC(C)(C(=O)/C=C/Cl)C1.[I-]>>CCC1CC(C)(C(=O)/C=C/I)C1,,CC(C)=O,,O=S(=O)(O)O,,val
US03952031,CO[C@H]1C[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC(C)=C(C(C)=O)[C@@]4(C)CC(=O)[C@@H]32)C[C@@H]1O>>CO[C@H]1C[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4C[C@H](C)[C@H](C(C)=O)[C@@]4(C)CC(=O)[C@@H]32)C[C@@H]1O,[Pd],CCOC(C)=O,,[H][H],,val
US20070299039A1,CNC.O=C(Cl)c1cc(Cl)ccn1>>CN(C)C(=O)c1cc(Cl)ccn1,,ClCCl,,CCN(CC)CC,,val
US20150152112A1,N#Cc1ccc(-c2cnc(C3CCc4cc(-c5cc(Cl)ccc5-n5cnnn5)cc(=O)n43)[nH]2)cc1F.NN>>Nc1n[nH]c2cc(-c3cnc(C4CCc5cc(-c6cc(Cl)ccc6-n6cnnn6)cc(=O)n54)[nH]3)ccc12,,O,,CO,,val
US20090093524A1,CCOC(=O)c1c(C(F)(F)F)nnn1-c1c(Cl)cccc1Cl>>OCc1c(C(F)(F)F)nnn1-c1c(Cl)cccc1Cl,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20070010670A1,O=C(Cl)c1ccc(Cl)c(O)c1.c1ccc2c(c1)NCCO2>>O=C(c1ccc(Cl)c(O)c1)N1CCOc2ccccc21,,CCOC(C)=O,,,,val
US20090264401A1,COC(=O)CC(=O)C1CCC1.COC(OC)N(C)C>>COC(=O)/C(=C\N(C)C)C(=O)C1CCC1,,C1COCCO1,,,,val
US20100305096A1,CC(C)(C)OC(=O)N1CC(C(=O)O)C1.O[C@H]1CCNC1>>CC(C)(C)OC(=O)N1CC(C(=O)N2CC[C@H](O)C2)C1,,ClCCl,ClCCl,CCN=C=NCCCN(C)C,Cl,val
US20160272604A1,C1=COCCC1.OCCOCCOCCBr>>BrCCOCCOCCC1CCCCO1,,CCOCC,,O=C([O-])O.[Na+],,val
US06221604B1,COc1cc2ccccc2c(OC)c1Br.OB(O)c1cccnc1>>COc1cc2ccccc2c(OC)c1-c1cccnc1,,CCOC(C)=O,O,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20090137580A1,COCCOCCn1ccc2ncnc(Oc3ccc(N)c(Cl)c3)c21.O=C=Nc1cccc(C(F)(F)F)c1>>COCCOCCn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(Cl)c3)c21,,C1CCOC1,,CCN(CC)CC,,val
US20140031342A1,FC(F)(F)Oc1ccc(COc2ccc(CC3CCNCC3)cc2)cc1.Oc1ccc2nc(Cl)sc2c1>>Oc1ccc2nc(N3CCC(Cc4ccc(OCc5ccc(OC(F)(F)F)cc5)cc4)CC3)sc2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130261178A1,CC(C)(C)OC(=O)NCCNC(=O)Nc1ccc(OCCF)cc1.Cl>>Cl.NCCNC(=O)Nc1ccc(OCCF)cc1,CO,ClCCl,,C1COCCO1,,val
US20140378447A1,COC(=O)C1CCn2nc(Br)nc2C1>>O=C(O)C1CCn2nc(Br)nc2C1,,O,,CO,[Na+].[OH-],val
US20130059834A1,CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C4CCN(C(=O)OC(C)(C)C)CC4)c4cc(F)ccc34)nc12>>CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(C4CCNCC4)c4cc(F)ccc34)nc12,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US20120065214A1,Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(NC2(c3cc(F)ccc3O)CC2)c1=O.ClCCBr>>Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(NC2(c3cc(F)ccc3OCCCl)CC2)c1=O,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04316900,COC1CCC(OC)O1.NCc1ccccc1[N+](=O)[O-]>>O=[N+]([O-])c1ccccc1Cn1cccc1,,O,,CC(=O)O,,val
US05134238,CC1CC=CC(=O)C1.CCOCC.CN[C@H](CN1CCCCC1)c1ccccc1.[Li]CCCC>>CCCC[C@@H]1CC(=O)C[C@@H](C)C1.C[C@@H]1CC=CC(=O)C1,[Cu]I,CCOCC,CCOCC,,,val
US20150166480A1,CC1(C)CO1.Clc1ccc(OCC2CCNCC2)nn1>>CC(C)(O)CN1CCC(COc2ccc(Cl)nn2)CC1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20080221100A1,N#Cc1ccc(C(=O)O)cc1.O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCNCC1>>N#Cc1ccc(C(=O)N2CCC(NC(=O)Nc3ccc(C(F)(F)F)cc3)CC2)cc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US05194442,C[Si](C)(C)Oc1ccc(Cl)cn1.c1ccc2c(c1)OCCC1OC21>>O=c1ccc(Cl)cn1[C@@H]1c2ccccc2OCC[C@H]1O,,O,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150038488A1,COCCC(=O)[C@@H]1CC(=O)N([C@H](C)c2ccc(OC)cc2)C1>>CCC(O)[C@@H]1CC(=O)N([C@H](C)c2ccc(OC)cc2)C1,,CCO,,[BH4-].[Na+],,val
US20080096877A1,CCN=C=NCCCN(C)C.O=C(O)CC1CN=C(c2cc3cc(OC(F)(F)F)cc(NS(=O)(=O)c4cccs4)c3[nH]2)S1>>NC(=O)CC1CN=C(c2cc3cc(OC(F)(F)F)cc(NS(=O)(=O)c4cccs4)c3[nH]2)S1,,O,,CN(C)C=O,Cl,val
US20100137294A1,CCCCCCCCCCN.O=C1OC(=O)C2C3CCC(O3)C12>>CCCCCCCCCCN1C(=O)C2C3CCC(O3)C2C1=O,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,,val
US20040266774A1,COC(=O)c1cccc(-c2cccs2)c1>>O=C(O)c1cccc(-c2cccs2)c1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US04371391,CNc1nc(OC)nc(OC)n1.CS(=O)(=O)c1ccccc1S(=O)(=O)N=C=O>>COc1nc(OC)nc(N(C)C(=O)NS(=O)(=O)c2ccccc2S(C)(=O)=O)n1,,ClCCl,,,,val
US20050187230A1,CI.O=c1[nH]c2ccncc2cc1-c1c(Cl)ccc([N+](=O)[O-])c1Cl>>Cn1c(=O)c(-c2c(Cl)ccc([N+](=O)[O-])c2Cl)cc2cnccc21,,CCOC(C)=O,CN(C)C=O,,,val
US20120208814A1,CC(=O)N1c2ccc(Br)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.CCOC(=O)c1ccc(B(O)O)cc1>>CCOC(=O)c1ccc(-c2ccc3c(c2)[C@H](NC(=O)OC(C)C)C[C@H](C)N3C(C)=O)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US04440566,CC1(C)CC(=O)CC(=O)C1.CCCC(=O)Cl>>CCCC(=O)OC1=CC(=O)CC(C)(C)C1,,ClCCl,,c1ccncc1,,val
US20160096839A1,COc1cc(-c2c(C(C)(F)F)ccc(Cl)c2F)ncn1>>CC(F)(F)c1ccc(Cl)c(F)c1-c1cc(O)ncn1,,Cc1ccccc1,,Br,CC(=O)O,val
US04925849,NNC(N)=O.O=Cc1c(-c2ccccc2)nn2ccccc12>>NC(=O)NN=Cc1c(-c2ccccc2)nn2ccccc12,,CCO,,Cl,,val
US20150376136A1,CN1C(=O)NC(=O)C1(C)C1CCCCC1.O=C(CBr)c1cccc(Cl)c1>>CN1C(=O)N(CC(=O)c2cccc(Cl)c2)C(=O)C1(C)C1CCCCC1,,CN(C)C=O,,[H-].[Na+],,val
US20020013460A1,C#Cc1ccc(OC)cc1.N#Cc1cnccc1Cl>>COc1ccc(C#Cc2ccncc2C#N)cc1,,CN(C)C=O,,CCN(CC)CC,O,val
US20050261358A1,CN(C)C1(c2ccccc2)CCC(CCNC(=S)NCCc2c[nH]c3ccccc23)CC1.Cl>>CN(C)C1(c2ccccc2)CCC(CCNC(=S)NCCc2c[nH]c3ccccc23)CC1.Cl,,CCC(C)=O,,C[Si](C)(C)Cl,,val
US06300363B1,CC(=O)O[C@@H](C)C(=O)Cl.Nc1c(C(=O)c2ccccc2)[nH]c2cc(Cl)ccc12>>CC(=O)O[C@@H](C)C(=O)Nc1c(C(=O)c2ccccc2)[nH]c2cc(Cl)ccc12,,CO,,,,val
US20060106027A1,O=[N+]([O-])c1ccc(Cl)cc1.OCCN1CCOCC1>>O=[N+]([O-])c1ccc(OCCN2CCOCC2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20090023763A1,CSc1nccc(-c2cc([N+](=O)[O-])c(N)nc2-c2ccco2)n1>>CSc1nccc(-c2cc(N)c(N)nc2-c2ccco2)n1,[Fe],CCO,,Cl,,val
US20110172237A1,Br[Mg]c1ccccc1.N#CC1CCCCCC1.O=S(=O)(O)O>>O=C(c1ccccc1)C1CCCCCC1,,CCOCC,,Cl,,val
US20050214568A1,Cc1ccc(C2(c3ccccc3)c3cc(Br)ccc3-c3ccc(Br)cc32)cc1.O=C1CCC(=O)N1Br>>BrCc1ccc(C2(c3ccccc3)c3cc(Br)ccc3-c3ccc(Br)cc32)cc1,,ClC(Cl)(Cl)Cl,,,,val
US20020082254A1,CC1Cc2ccccc2CN1N.O=C(Cl)Oc1ccc(Cl)cc1>>CC1Cc2ccccc2CN1NC(=O)Oc1ccc(Cl)cc1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US05714508,CCCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)N=CN(C)C)cc1)C(=O)C(F)CS2>>CCCCc1nc2c(n1Cc1ccc(-c3ccccc3S(N)(=O)=O)cc1)C(=O)C(F)CS2,,CCO,,Cl,,val
US20090203690A1,CC1(C)OB(c2cnn(Cc3ccccc3)c2)OC1(C)C.N#Cc1cc(Br)ccc1F>>N#Cc1cc(-c2cnn(Cc3ccccc3)c2)ccc1F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,ClCCl,O,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US04489078,CI.O=C1c2[nH]c(=S)[nH]c2N(Cc2ccc(Cl)cc2)C2=NCCN12>>CSc1nc2c([nH]1)N(Cc1ccc(Cl)cc1)C1NCCN1C2=O,,[Na+],[OH-],O,,val
US20130096113A1,CSc1nc2ccc(Cn3cnc4cccnc43)cc2o1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc2ccc(Cn3cnc4cccnc43)cc2o1,,ClCCl,,O=C([O-])O.[Na+],,val
US20060167020A1,Clc1ncnc2c1cnn2-c1ccncc1.NN>>NNc1ncnc2c1cnn2-c1ccncc1,,CCO,,,,val
US20160115268A1,CCP(CC)CC.OCCCCCCCCCCCCBr>>CC[P+](CC)(CC)CCCCCCCCCCCCO.[Br-],,CC#N,,,,val
US20060257987A1,COC(=O)CCc1ccc(OCC[C@H](C)Oc2ncc(Cl)cc2-c2cccnc2)cc1C>>Cc1cc(OCC[C@H](C)Oc2ncc(Cl)cc2-c2cccnc2)ccc1CCC(=O)O,,CO,,Cl,[Na+].[OH-],val
US20090286812A1,BrCc1ccccc1.CC(C)(C)OC(=O)N1CCC(n2ncc3c(Nc4ccc(S(C)(=O)=O)cc4F)ncnc32)CC1>>CS(=O)(=O)c1ccc(Nc2ncnc3c2cnn3C2CCN(Cc3ccccc3)CC2)c(F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150231143A1,CCN(CC)CC.CN(C)C=O.ClCCl.NS(=O)(=O)c1ccc(-c2cc(-c3ccc(Cl)cc3)sc2C(=O)O)cc1.O=C(Cl)C(=O)Cl>>CON(C)C(=O)c1sc(-c2ccc(Cl)cc2)cc1-c1ccc(S(=O)(=O)N=CN(C)C)cc1,,ClCCl,ClCCl,,,val
US20130303515A1,CCOC(=O)CCCBr.Nc1cccc(C(F)(F)F)c1>>CCOC(=O)CCCNc1cccc(C(F)(F)F)c1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US05098918,COc1ccccc1.O=C(Cl)Cc1cccs1>>COc1ccc(C(=O)Cc2cccs2)cc1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20020032132A1,O=Cc1ccccc1C(=O)O.OCCc1ccccc1>>O=Cc1ccccc1C(=O)OCCc1ccccc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20020006927A1,O=C(CCl)Nc1ccc2[nH]c(=O)c3ccccc3c2c1.c1ccc2c(c1)CNC2>>O=C(CN1Cc2ccccc2C1)Nc1ccc2[nH]c(=O)c3ccccc3c2c1,,CN(C)C=O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US04013678,CN(CCS)C(N)=S.Cc1[nH]cnc1CCl>>Cc1[nH]cnc1CSCCN(C)C(N)=S,,CCO,,Cl,[Na],val
US04839353,CC(=O)c1cccc2ccccc12.Cc1cnc(C=O)cc1N1CCCCC1>>Cc1cnc(C=CC(=O)c2cccc3ccccc23)cc1N1CCCCC1,,CO,,[Na+].[OH-],,val
US05616637,CC(=O)OC1CC(C)(C)N(OC2CCCCC2)C(C)(C)C1>>CC1(C)CC(O)CC(C)(C)N1OC1CCCCC1,,CO,,[K+].[OH-],,val
US20030176418A1,CCCCC1CCNCC1.C[C@@H](CI)CN1C(=O)COc2ccccc21>>CCCCC1CCN(C[C@H](C)CN2C(=O)COc3ccccc32)CC1,,CC#N,,,,val
US20090318493A1,CC(C)(C)CCC1(C(O)c2csc3ccc(F)cc23)CCN(C(=O)OC(C)(C)C)C1>>CC(C)(C)CCC1(C(=O)c2csc3ccc(F)cc23)CCN(C(=O)OC(C)(C)C)C1,O=[Mn]=O,,,,,val
US20110065702A1,CN(C)S(=O)(=O)Cl.Nc1ccc2c(c1)CC(=O)N2>>CN(C)S(=O)(=O)Nc1ccc2c(c1)CC(=O)N2,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,,,val
US20060116356A1,CCOP(=O)(CO)OCC.Cc1ccc(S(=O)(=O)Cl)cc1>>CCOP(=O)(COS(=O)(=O)c1ccc(C)cc1)OCC,,ClCCl,,,,val
US20060258722A1,COC(=O)Cc1coc2cc(O)ccc12>>COC(=O)CC1COc2cc(O)ccc21,[Pd],CO,,,,val
US20150353553A1,CC(=O)c1nc(N[C@H](C)C2CCC2)c2c(n1)nc(-c1cc(C(C)C)ccn1)n2C[C@H]1CC[C@H](C)CC1>>CC(C)c1ccnc(-c2nc3nc(C(C)O)nc(N[C@H](C)C4CCC4)c3n2C[C@H]2CC[C@H](C)CC2)c1,,C1CCOC1,CO,[BH4-].[Na+],,val
US20060173214A1,COc1ccc(CC(C)=NO)cc1S(N)(=O)=O>>COc1ccc(CC(C)N)cc1S(N)(=O)=O,[Ni],CO,,,,val
US20120015962A1,CC(C)(C)OC(=O)NCC1CCNCC1.O=[N+]([O-])c1cc2cccnc2cc1Cl>>CC(C)(C)OC(=O)NCC1CCN(c2cc3ncccc3cc2[N+](=O)[O-])CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140275080A1,CC(C)c1ncc(-c2cc(Oc3ccc([N+](=O)[O-])nc3)ccn2)[nH]1>>CC(C)c1ncc(-c2cc(Oc3ccc(N)nc3)ccn2)[nH]1,[Pd],CO,,,,val
US20160090381A1,Cc1c([N+](=O)[O-])cnc2c1c(C1=CCN(C(=O)OC(C)(C)C)C(C)(C)C1)cn2C>>Cc1c([N+](=O)[O-])cnc2c1c(C1=CCNC(C)(C)C1)cn2C,,C1COCCO1,,Cl,,val
US04405552,Nc1ncc(-c2ccc(Cl)cc2)cc1C(=O)O>>Nc1ccc(-c2ccc(Cl)cc2)cn1,[Cu],c1ccc2ncccc2c1,,,,val
US20120077814A1,CC1(C)O[C@H]2C(c3c[nH]c4c(N[C@H]5CCc6ccccc65)ncnc34)O[C@H](CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)[C@H]2O1>>CC1(C)O[C@H]2[C@@H](O1)[C@H](c1c[nH]c3c(N[C@H]4CCc5ccccc54)ncnc13)O[C@@H]2CO,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20060040999A1,COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN(C(=O)OC(C)(C)C)[C@@H](C)[C@H](N=[N+]=[N-])c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN[C@@H](C)[C@H](N=[N+]=[N-])c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06498174B1,CCC(=O)CC(=O)c1ccccc1.COc1ccc(C(C)=O)cc1>>COc1ccc(C(=O)CC(C)=O)cc1,,CCOC(C)=O,,,,val
US06599917B1,Clc1ncc(Br)c(Cc2ccccc2)n1.OCc1ccco1>>Brc1cnc(OCc2ccco2)nc1Cc1ccccc1,,CCOCC,,O,[H-].[Na+],val
US20020156081A1,C1COCCN1.Nc1ncnc2c1c(I)nn2CCCBr>>Nc1ncnc2c1c(I)nn2CCCN1CCOCC1,,CN(C)C=O,,CCN(CC)CC,,val
US20140221392A1,CCCN(C(=O)[C@@H]1CC[C@@H](Oc2ccc(F)cn2)CC1)c1ccc(CN2CCN(C(=O)OC(C)(C)C)CC2)c(C)c1>>CCCN(C(=O)[C@@H]1CC[C@@H](Oc2ccc(F)cn2)CC1)c1ccc(CN2CCNCC2)c(C)c1,,ClCCl,,Cc1ccccc1,O=C(O)C(F)(F)F,val
US20140045831A1,C[C@@H](C(=O)O)N(C)C(=O)OC(C)(C)C>>CNC(=O)OC(C)(C)C,,CN(C)C=O,,,,val
US20060235222A1,CCC(O)(CC)c1ccc(F)cc1.Cn1ccc2cccc([N+](=O)[O-])c21>>CCC(CC)(c1ccc(F)cc1)c1cn(C)c2c([N+](=O)[O-])cccc12,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20060241302A1,CC(C)(C)OC(=O)NCCNC(=S)c1ccc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)nc1>>NCCNC(=S)c1ccc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)nc1,,CCO,,Cl,,val
US20040152699A1,CCNC(=S)NN.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCn1c(S)nnc1C(F)(F)F,,C1CCOC1,,CCN(CC)CC,,val
US20080306060A1,CC(C)(C)OC(=O)N[C@@H](Cc1cccc(Br)c1)C(=O)O>>N[C@@H](Cc1cccc(Br)c1)C(=O)O,,C1COCCO1,Cl,,,val
US20160083400A1,CCOC(=O)c1noc(C(C)C)c1N>>CC(C)c1onc(C(=O)O)c1N,,C1CCOC1,,Cl,[Na+].[OH-],val
US20140378446A1,COCCOc1ccc(-n2c(=O)n(-c3ccc(C)c(OC)c3)c3c(N)ncnc32)cc1N(C)C(=O)OC(C)(C)C>>CNc1cc(-n2c(=O)n(-c3ccc(C)c(OC)c3)c3c(N)ncnc32)ccc1OCCOC,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140275528A1,Brc1ccccn1.COc1cccc(Cn2c(Oc3ccc(B4OC(C)(C)C(C)(C)O4)cc3)nc3c2c(=O)n(C)c(=O)n3C)c1>>COc1cccc(Cn2c(Oc3ccc(-c4ccccn4)cc3)nc3c2c(=O)n(C)c(=O)n3C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100216746A1,Fc1c(CBr)ccc(Cl)c1Oc1cccc2ccccc12.N>>NCc1ccc(Cl)c(Oc2cccc3ccccc23)c1F,,ClCCl,,CO,,val
US20110257241A1,CC(C)(C)OC(=O)N1CCC(O)(c2ccc(F)c(Cl)c2)C1.CI>>COC1(c2ccc(F)c(Cl)c2)CCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,[H-].[Na+],,val
US20090286778A1,CC(C)(C)OC(=O)Nc1cccc(CCSCc2cccc([N+](=O)[O-])c2)c1>>Nc1cccc(CCSCc2cccc([N+](=O)[O-])c2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06492421B1,COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(C)cc1>>COC(=O)[C@@H](N)Cc1ccc(O)cc1,,CCC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20030153568A1,CCNC(=O)Nc1nc2ccc(C(=O)CCN)cc2s1.O=C(Cl)c1ccc(F)cc1>>CCNC(=O)Nc1nc2ccc(C(=O)CCNC(=O)c3ccc(F)cc3)cc2s1,,CN(C)C=O,,CCN(CC)CC,,val
US20060122168A1,O=C1Nc2cc(F)ccc2O[C@H](C(F)(F)F)[C@@H]1N(Cc1ccccc1)Cc1ccccc1>>N[C@@H]1C(=O)Nc2cc(F)ccc2O[C@@H]1C(F)(F)F,[Pd],CO,,,,val
US20030144250A1,O=P(OCc1ccccc1)(OCc1ccccc1)OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F>>O=P(O)(O)OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F,[Pd],O,,O=S(=O)(O)O,[Na+].[OH-],val
US20120202785A1,CO[C@@H]1C[C@@H](n2c([C@H](C)N)nc3ccc(F)cc32)C1.Clc1ncnc2c1ncn2C1CCCCO1>>COC1CC(n2c([C@H](C)Nc3ncnc4[nH]cnc34)nc3ccc(F)cc32)C1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20100016330A1,C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1>>C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1S(=O)(=O)c1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US04489093,CCOC(=O)/C(Cl)=C/[C@H]1[C@@H](C(=O)O)C1(C)C.N#C[C@@H](O)c1cccc(Oc2ccccc2)c1>>CCOC(=O)/C(Cl)=C/[C@H]1[C@@H](C(=O)O[C@H](C#N)c2cccc(Oc3ccccc3)c2)C1(C)C,,ClC(Cl)Cl,,,,val
US20140094459A1,CC(C)(C=O)N1CCOCC1.N#CCC(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21>>CC(C)(C=C(C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21)N1CCOCC1,,CCO,,C1CCNCC1,,val
US20080234237A1,CCN(C)CC(=O)N1CCCc2cc(Br)ccc21>>CCN(C)CCN1CCCc2cc(Br)ccc21,,C1CCOC1,CO,,,val
US20110257151A1,CCOC(=O)c1ccc(N)cc1.O=Cc1ccc(Br)cc1>>CCOC(=O)c1ccc(N=Cc2ccc(Br)cc2)cc1,,CCO,,,,val
US04873244,Cn1c(=O)c2c(Cl)cccc2n2cnc(-c3noc(C4CC4)n3)c12.Oc1cccc(Cl)c1>>Cn1c(=O)c2c(Oc3cccc(Cl)c3)cccc2n2cnc(-c3noc(C4CC4)n3)c12,,CCOCC,CN(C)C=O,O,[H-].[Na+],val
US20020165241A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC1CCN(C(=O)OCc2ccccc2)CC1>>CC(C)(C)OC(=O)NCC1CCN(C(=O)OCc2ccccc2)CC1,,ClCCl,,,,val
US20030060631A1,CC(=O)Nc1c(F)c(F)c(C)c2c1c(=O)c(C(=O)O)cn2[C@@H]1C[C@@H]1F.CC(C)(C)OC(=O)NC1([C@H]2CNC[C@H]2F)CC1>>CC(=O)Nc1c(F)c(N2C[C@H](C3(NC(=O)OC(C)(C)C)CC3)[C@H](F)C2)c(C)c2c1c(=O)c(C(=O)O)cn2[C@@H]1C[C@@H]1F,,CS(C)=O,,,,val
US20080161254A1,CC(=O)O.O=C[C@H](CC1CCC1)NC(=O)OCC1c2ccccc2-c2ccccc21.[C-]#[N+]C1CC1>>CC(=O)OC(C(=O)NC1CC1)[C@H](CC1CCC1)NC(=O)OCC1c2ccccc2-c2ccccc21,,ClCCl,,CCOC(C)=O,,val
US20140155389A1,COc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1nc(Nc2ccccc2Cl)cc2cn[nH]c(=O)c12>>COc1cc(N2CCNCC2)ccc1Nc1nc(Nc2ccccc2Cl)cc2cn[nH]c(=O)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US04044140,N#Cc1ccc(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.O>>NC(=O)c1ccc(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,,CO,,[K+].[OH-],,val
US20050113387A1,COc1ccc(-c2nc(C#N)c(N)nc2Cl)cn1.OB(O)c1ccccc1>>COc1ccc(-c2nc(C#N)c(N)nc2-c2ccccc2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20120142714A1,CCOc1ccc(C#Cc2ccc(OC[C@H](C)NC(=O)OC(C)(C)C)cc2)nc1.Cc1cc(C)c(S(=O)(=O)ON)c(C)c1>>CCOc1ccc2cc(-c3ccc(OC[C@H](C)NC(=O)OC(C)(C)C)cc3)nn2c1,,C1CCOC1,,,,val
US20110275797A1,COC(=O)c1ccc(-c2ccccc2)cc1NC(=O)c1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1O.Cl>>COC(=O)c1ccc(-c2ccccc2)cc1NC(=O)c1ccc(OC2CCNCC2)cc1O.Cl,,CCOC(C)=O,,C1COCCO1,,val
US20070010511A1,COC(=O)CCc1ccccc1OCCOC1CNCCC1c1ccc(OCCCOCc2ccccc2OC)cc1.O=C(Cl)OCc1ccccc1>>COC(=O)CCc1ccccc1OCCOC1CN(C(=O)OCc2ccccc2)CCC1c1ccc(OCCCOCc2ccccc2OC)cc1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20130168656A1,COc1ccc(B(O)O)cc1.O=[N+]([O-])c1ccccc1I>>COc1ccc(-c2ccccc2[N+](=O)[O-])cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20070123512A1,CN(C)CCOc1ccc(OCc2ccccc2)cc1>>CN(C)CCOc1ccc(O)cc1,,CCO,,Cl,,val
US20100261728A1,NCCc1ccccc1F.O=C(Cl)c1ccc(C(F)(F)F)cc1>>O=C(NCCc1ccccc1F)c1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150376130A1,COC(=O)c1cc(Cl)cnc1Nc1cccnc1>>O=C(O)c1cc(Cl)cnc1Nc1cccnc1,,C1CCOC1,O,[Li+].[OH-],,val
US20080108648A1,COc1cc(C(=O)Cl)ccc1[N+](=O)[O-].c1ccn2cncc2c1>>COc1cc(C(=O)c2ncc3ccccn23)ccc1[N+](=O)[O-],,ClCCCl,,CCN(CC)CC,,val
US04474786,N#Cc1cc2c([nH]c1=O)OCc1ccccc1-2.S>>NC(=S)c1cc2c([nH]c1=O)OCc1ccccc1-2,,CCN(CC)CC,,c1ccncc1,,val
US05192775,Clc1nc2ccccc2s1.OCC1CCNCC1>>OCC1CCN(c2nc3ccccc3s2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20030078426A1,CC(C)c1cccc(C(C)C)c1N=C=O.Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccc(Oc3ccc4cccc(N)c4c3)cc21>>CC(C)c1cccc(C(C)C)c1NC(=O)Nc1cccc2ccc(Oc3ccc4nc(COc5ccc(CC6SC(=O)NC6=O)cc5)n(C)c4c3)cc12,,CN(C)C=O,,,,val
US04608383,Cc1cccc(C)c1NCCCN.c1ccc(COc2ccc(OCC3CO3)cc2)cc1>>Cc1cccc(C)c1NCCCNCC(O)COc1ccc(OCc2ccccc2)cc1,,CC(C)O,,,,val
US20010031876A1,O=C(OCCS(=O)(=O)CCCOCCc1ccccc1)c1ccccc1>>C=CS(=O)(=O)CCCOCCc1ccccc1,,CCOC(C)=O,,C1CCC2=NCCCN2CC1,,val
US20100311729A1,CN(C)C=O.O=C(C1CCNCC1)N1CCCCC1.OB(O)c1ccccc1>>O=C(C1CCN(Cc2ccc(B(O)O)cc2)CC1)N1CCCCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04413002,BrBr.CCOC(=O)C(CCCCCCCOC1CCCCO1)C(C)=O>>CCOC(=O)C(Br)(CCCCCCCOC1CCCCO1)C(C)=O,,C1CCOC1,ClCCl,[H-].[Na+],,val
US05124470,CCOc1ccc(Br)cc1.C[Mg]Cl.[SiH3]C(Cl)Cl>>CCOc1ccc([SiH](C)C)cc1,,C1CCOC1,O,[Mg],,val
US20060014739A1,Br[Mg]CCC1OCCCO1.N#Cc1ccc(N2C3CCC2CC(=O)C3)c2ccccc12>>N#Cc1ccc(N2C3CCC2CC(O)(CCC2OCCCO2)C3)c2ccccc12,,C1CCOC1,,,,val
US20060263816A1,CC(=O)CCCC(=O)O.O=C(Oc1c(F)c(F)c(F)c(F)c1F)C(F)(F)F>>CC(=O)CCCC(=O)Oc1c(F)c(F)c(F)c(F)c1F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05885999,COC(=O)C1(c2ccccc2)CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1>>O=C([C@H](COCc1ccc(Cl)c(Cl)c1)NCc1ccccc1)N1CCC(CO)(c2ccccc2)CC1,,C1CCOC1,Cc1ccccc1,[BH4-].[Li+],,val
US20160207930A1,CC(C)(C)OC(=O)N1CCN2C(=O)CC[C@H]2C1=O.Cc1c(Cl)cccc1Br>>Cc1c(Cl)cccc1C(=O)[C@@H]1CCC(=O)N1CCNC(=O)OC(C)(C)C,,C1CCOC1,,[Li]CCCC,,val
US04380546,CC(C)(C)C(=O)C(CCOc1ccccc1)n1cncn1.C[Mg]Br>>CC(C)(C)C(C)(O)C(CCOc1ccccc1)n1cncn1,,C1CCOC1,,[Cl-].[NH4+],,val
US20020183361A1,CCC(CCO)C(C)CO.CCN(CC)CC.O=S(=O)(Cl)c1ccc(Cl)s1>>CCC(CCO)C(CO)NS(=O)(=O)c1ccc(Cl)s1,,ClCCl,,CCCCCC,CCOC(C)=O,val
US20110294830A1,COC(C)CC(=O)NC1CCc2cc(C(/C=C(/c3cc(Cl)cc(Cl)c3)C(F)(F)F)=NO)ccc21.COCCl>>COCON=C(/C=C(/c1cc(Cl)cc(Cl)c1)C(F)(F)F)c1ccc2c(c1)CCC2NC(=O)CC(C)OC,,C1CCOC1,,[H-].[Na+],,val
US20010051651A1,CCOC(=O)Cc1cccn1C.O=C(Cl)c1ccc(Cl)cc1>>CCOC(=O)Cc1ccc(C(=O)c2ccc(Cl)cc2)n1C,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130116250A1,COC(=O)c1cc(C(=O)c2nc(Br)c3ccccn23)ccc1NC(=O)NCCOc1ccc(F)cc1>>O=C(c1ccc2[nH]c(=O)n(CCOc3ccc(F)cc3)c(=O)c2c1)c1nc(Br)c2ccccn12,,CO,O,Cl,[Na+].[OH-],val
US20110034452A1,BrCC1CCCCC1.CC(=O)c1cc(O)cc(O)c1.CCBr>>CCOc1cc(OCC2CCCCC2)cc(C(C)=O)c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20100286126A1,CCC(=O)N[C@H]1C[C@@H](n2cnc3c(NC(c4ccc(OC)cc4)c4ccc(OC)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O.NN>>CCC(=O)N[C@H]1C[C@@H](n2cnc3c(NC(c4ccc(OC)cc4)c4ccc(OC)cc4)nc(NN)nc32)[C@H](O)[C@@H]1O,,O,,CC(C)O,,val
US20100069328A1,COC(=O)C(CC1CCN(C)CC1)c1ccc(/C=C/C(=O)Nc2ccccc2NC(=O)OC(C)(C)C)cc1>>CN1CCC(CC(C(=O)O)c2ccc(/C=C/C(=O)Nc3ccccc3NC(=O)OC(C)(C)C)cc2)CC1,,CO,O,Cl,[Li+].[OH-],val
US20100068197A1,CC(=O)Cl.COc1ccc(N(C)c2nc(NCCN)nc3ccccc23)cc1OC>>COc1ccc(N(C)c2nc(NCCNC(C)=O)nc3ccccc23)cc1OC,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080300270A1,C/C(N)=C\C#N.CCCC1CC(=O)CC(=O)C1.O=Cc1cc(Br)c(O)c([N+](=O)[O-])c1>>CCCC1CC(=O)C2=C(C1)NC(C)=C(C#N)C2c1cc(Br)c(O)c([N+](=O)[O-])c1,,CCO,,,,val
US20070213371A1,CC(C)[Si](Cl)(C(C)C)C(C)C.OCc1cc(C(F)(F)F)ccc1Br>>CC(C)[Si](OCc1cc(C(F)(F)F)ccc1Br)(C(C)C)C(C)C,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20130123304A1,C=CCC1CCC(OCC)=CC1=O>>C=CCC1C=CC(=O)CC1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070270422A1,CI.COC(=O)Cc1ccc(Oc2ccc([N+](=O)[O-])cn2)cc1>>COC(=O)C(C)c1ccc(Oc2ccc([N+](=O)[O-])cn2)cc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20100075946A1,CN.Cc1cc(CCC(=O)c2cc(-c3ccccc3)c(C)s2)cc(C)c1OCC1CO1>>CNCC(O)COc1c(C)cc(CCC(=O)c2cc(-c3ccccc3)c(C)s2)cc1C,,CO,,,,val
US04508716,COc1ccc2c(c1)N1CCOCC1CN=C2c1ccco1.O=C(OO)c1cccc(Cl)c1>>COc1ccc2c(c1)N1CCOCC1C[N+]([O-])=C2c1ccco1,,ClCCl,,[Na+].[OH-],,val
US20110092547A1,O=C(Cl)C1CC(OCc2ccccc2)C1.OCCc1ccccc1>>O=C(OCCc1ccccc1)C1CC(OCc2ccccc2)C1,,CCOCC,ClCCl,c1ccncc1,,val
US20130331374A1,Cc1ccc(S(=O)(=O)Cl)cc1.Cn1nc2n(c1=O)-c1cc([N+](=O)[O-])ccc1OC2(CO)CO>>Cc1ccc(S(=O)(=O)OCC2(CO)Oc3ccc([N+](=O)[O-])cc3-n3c2nn(C)c3=O)cc1,,ClCCl,,CCN(CC)CC,c1ccncc1,val
US06696437B1,NC(=O)c1cccc(N)c1N.O=C(O)c1cn[nH]c1>>NC(=O)c1cccc2nc(-c3cn[nH]c3)[nH]c12,,CN(C)C=O,c1ccncc1,O=C(n1ccnc1)n1ccnc1,,val
US04820698,C=O.CCCCCCOP(=O)(CP(=O)(OCCCCCC)OCCCCCC)OCCCCCC>>C=C(P(=O)(OCCCCCC)OCCCCCC)P(=O)(OCCCCCC)OCCCCCC,,CO,,CCNCC,,val
US20120040998A1,CC(=O)c1ccc(F)cn1.O=[N+]([O-])c1ccc(S(=O)(=O)OI(O)c2ccccc2)c([N+](=O)[O-])c1>>O=C(COS(=O)(=O)c1ccc([N+](=O)[O-])cc1[N+](=O)[O-])c1ccc(F)cn1,,CC#N,,,,val
US20130017194A1,C#Cc1ccccc1CC(=O)OC.CC(C)(C)OC(=O)N1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(Cl)n3)cc2)CC1>>COC(=O)Cc1ccccc1C#Cc1nc(Nc2ccc(C3CCN(C(=O)OC(C)(C)C)CC3)cc2)ncc1C(F)(F)F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050176706A1,COC(=O)c1ccc(I)c(N)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1ccc(I)c(NC(=O)C(F)(F)F)c1,,ClCCl,,,,val
US20070264341A1,C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O>>C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O,,CC(=O)O,,,,val
US04746353,COc1cc(OC)nc(NC(=O)Oc2ccccc2)n1.Cc1nnnn1-c1ccccc1S(N)(=O)=O>>COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ccccc2-n2nnnc2C)n1,,CC#N,,C1CCC2=NCCCN2CC1,Cl,val
US20100216836A1,O=C(O)[C@H]1COc2ccccc2O1>>OC[C@H]1COc2ccccc2O1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05668088,BrP(Br)Br.Cc1c(-c2cc(CO)c(Cl)cc2F)nn(C)c1C(F)(F)F>>Cc1c(-c2cc(CBr)c(Cl)cc2F)nn(C)c1C(F)(F)F,,CCOCC,,,,val
US20070185089A1,CN.O=C(Cl)c1cnc(N2CCC(c3ccc4c(c3)CCN(C3CCC3)CC4)CC2)cn1>>CNC(=O)c1cnc(N2CCC(c3ccc4c(c3)CCN(C3CCC3)CC4)CC2)cn1,,ClCCl,,C1CCOC1,,val
US20130289012A1,Nc1nc([C@@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)no1>>Nc1nc([C@@H]2CC[C@@H]3CN2C(=O)N3O)no1,,ClCCl,,ClB(Cl)Cl,,val
US04083948,Oc1ccc(-c2onc3ccc(Cl)cc23)cc1>>Nc1ccc(Cl)cc1C(=O)c1ccc(O)cc1,[Fe],CC(=O)O,,O,,val
US20040010141A1,Cn1ncc2cc(Oc3ccc([N+](=O)[O-])cn3)ccc21>>Cn1ncc2cc(Oc3ccc(N)cn3)ccc21,O=[Pt]=O,CO,,CCOC(C)=O,,val
US06235730B1,Nc1ccccc1C(=O)O.O=CO>>O=CNc1ccccc1C(=O)O,,CCCCCC,,Cc1ccccc1,,val
US20120302541A1,CC(C)(C)OC(=O)N1CCC[C@H]1C=O.N#Cc1ccc(Oc2cc(-c3ccccc3)ccc2N)cc1>>CC(C)(C)OC(=O)N1CCC[C@H]1CNc1ccc(-c2ccccc2)cc1Oc1ccc(C#N)cc1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20050176775A1,COC(=O)c1ccc2c(c1)CN(C(=O)OCC(Cl)(Cl)Cl)C2>>O=C(OCC(Cl)(Cl)Cl)N1Cc2ccc(CO)cc2C1,,C1CCOC1,Cc1ccccc1,CC(C)C[AlH]CC(C)C,,val
US20050239751A1,C#Cc1cccc(NC(=O)C(Cl)(Cl)C(=O)OC)c1.ON=C(Cl)c1c(Cl)cccc1Cl>>COC(=O)C(Cl)(Cl)C(=O)Nc1cccc(-c2cc(-c3c(Cl)cccc3Cl)no2)c1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US04084001,CNC(=C[N+](=O)[O-])SC.NCCCCCCO>>CNC(=C[N+](=O)[O-])CCCCCCO,,CCO,,,,val
US05151420,CCC(=O)c1ccc(O)cc1O.Nc1ccc(C2=NNC(=O)CC2)cc1>>CCC(=Nc1ccc(C2=NNC(=O)CC2)cc1)c1ccc(O)cc1O,,CC(=O)N(C)C,,,,val
US05847159,OC1c2cccc(F)c2CCC1CCN1CCCC1>>Fc1cccc2c1CCC(CCN1CCCC1)=C2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20050272036A1,O=C(CCl)c1ccc(Cl)cc1Cl.c1ccc2[nH]cnc2c1>>O=C(Cn1cnc2ccccc21)c1ccc(Cl)cc1Cl,,CN(C)C=O,,O,[H-].[Na+],val
US20020147334A1,CCOC(=O)CC(Cc1ccc(C(=O)NCCNc2ccccn2)cc1)c1ccccc1>>O=C(O)CC(Cc1ccc(C(=O)NCCNc2ccccn2)cc1)c1ccccc1,,C1CCOC1,O,[Li+].[OH-],,val
US20100144710A1,CCCCBr.N#Cc1cccnc1N1CCN(C(=O)Cc2ccc(N)cc2)CC1>>CCCCNc1ccc(CC(=O)N2CCN(c3ncccc3C#N)CC2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US05985281,N[C@@H](CC(=O)O)C(=O)O.O=C(O)CNC(=O)c1ccccc1>>O=C(O)C[C@H](NC(=O)CNC(=O)c1ccccc1)C(=O)O,,CN(C)C=O,,CCN(CC)CC,O,val
US20120184735A1,COc1c(C=O)cc(C(C)(C)C)cc1[N+](=O)[O-].C[Si](C)(C)C(F)(F)F>>COc1c(C(O)C(F)(F)F)cc(C(C)(C)C)cc1[N+](=O)[O-],,C1CCOC1,,Cl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20130336921A1,C1CCNCC1.O=C(Nc1nc(-c2cccc(C(F)(F)F)c2)n[nH]1)c1cc(Cl)ccc1[N+](=O)[O-]>>O=C(Nc1nc(-c2cccc(C(F)(F)F)c2)n[nH]1)c1cc(N2CCCCC2)ccc1[N+](=O)[O-],,CCOC(C)=O,CN(C)C=O,,,val
US20090286811A1,COc1ccc(-c2c(C)nc3sccn3c2=O)cc1.COc1cccc(C=O)c1OCC1CC1>>COc1ccc(-c2c(/C=C/c3cccc(OC)c3OCC3CC3)nc3sccn3c2=O)cc1,,CCO,,C,C[O-].[Na+],val
US05385929,CC(C)c1c(C(=O)Nc2ccc(OCc3ccccc3)cc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H]1C[C@@H](O)CC(=O)O1>>CC(C)c1c(C(=O)Nc2ccc(O)cc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H]1C[C@@H](O)CC(=O)O1,[Pd],CCOC(C)=O,,,,val
US20110086858A1,COC(=O)c1ccc(Nc2nc(Cl)nc(OCC(F)(F)F)n2)cc1.NCc1ccc(O)cc1>>COC(=O)c1ccc(Nc2nc(NCc3ccc(O)cc3)nc(OCC(F)(F)F)n2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20110257207A1,CN(C)CCN.COn1c(=O)c(-c2cc([N+](=O)[O-])ccc2Cl)cc2cnc(S(C)(=O)=O)nc21>>COn1c(=O)c(-c2cc([N+](=O)[O-])ccc2Cl)cc2cnc(NCCN(C)C)nc21,,CC(C)O,,Cl,,val
US20120101124A1,CCOC(COc1cc(Br)ccc1OC)OCC>>COc1ccc(Br)c2ccoc12,,Clc1ccccc1,,[Na+].[OH-],,val
US20090137607A1,BrP(Br)Br.CC(O)c1ccc(-c2nc3nccn3cc2-c2ccccc2)cc1>>CC(Br)c1ccc(-c2nc3nccn3cc2-c2ccccc2)cc1,,ClCCl,,,,val
US20130102776A1,C=O.CC(C)(C)OC(=O)N1CCNCC1.O=C1/C(=C/c2c[nH]c3ccccc23)Cc2cc(O)ccc21>>CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2C/C(=C\c2c[nH]c4ccccc24)C3=O)CC1,,CCO,,,,val
US20090264401A1,CCOC(=O)c1cnc(N2CCOCC2)nc1C1CC1>>O=C(O)c1cnc(N2CCOCC2)nc1C1CC1,,CO,,[Na+].[OH-],,val
US20040236114A1,Cn1c(C=Cc2ccccc2)cc2cc(OCc3ccccc3)ccc21>>Cn1c(CCc2ccccc2)cc2cc(O)ccc21,[Pd],C1CCOC1,CCO,,,val
US20080167361A1,COc1cc(S(=O)(=O)c2ccccc2C#N)ccc1C1CCN(C(=O)OC(C)(C)C)C1>>COc1cc(S(=O)(=O)c2ccccc2C#N)ccc1C1CCNC1,,C1COCCO1,,Cl,,val
US20120171125A1,BrBr.Nc1cc(CO)ccn1>>Br.Nc1cc(CBr)ccn1,,CC#N,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100056791A1,COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(C=O)nn12.C[Mg]Br>>COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(C(C)O)nn12,,C1CCOC1,,[Cl-].[NH4+],,val
US04040812,CN1CCC(O)N(c2nnc(C(F)(F)F)s2)C1=O.COc1ccccc1OC(=O)Cl>>COc1ccccc1OC(=O)OC1CCN(C)C(=O)N1c1nnc(C(F)(F)F)s1,,c1ccncc1,,,,val
US04241079,CCCSc1ccc(C(=N)CC)c(NC(=S)NC(=O)OC)c1.CI>>CCCSc1ccc(C(=N)CC)c(NC(=NC(=O)OC)SC)c1,,CC(C)=O,O,[Na+].[OH-],,val
US20070155714A1,CC(=O)NC[C@H]1CN(c2ccc(OC3CNC3)c(F)c2)C(=O)O1.O=C(O)c1cn(C2CC2)c2nc(Cl)c(F)cc2c1=O>>CC(=O)NCC1CN(c2ccc(OC3CN(c4nc5c(cc4F)c(=O)c(C(=O)O)cn5C4CC4)C3)c(F)c2)C(=O)O1,,CN1CCCC1=O,,CCN(CC)CC,C[Si](C)(C)Cl,val
US20120142922A1,CC(C)Nc1ccc(Br)cc1N.COC(=O)c1ccc(N=C=S)cc1>>COC(=O)c1ccc(Nc2nc3cc(Br)ccc3n2C(C)C)cc1,,C1CCOC1,CCOC(C)=O,CCN=C=NCCCN(C)C,,val
US20030225051A1,BrCc1ccccc1.C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O>>C[C@]12CC[C@@H]3c4ccc(OCc5ccccc5)cc4CC[C@H]3[C@@H]1CCC2=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150266824A1,C[Si](C)(C)OC(C=O)c1c(Cl)cccc1Cl.NCC1(C(F)(F)F)CC1>>C[Si](C)(C)OC(CNCC1(C(F)(F)F)CC1)c1c(Cl)cccc1Cl,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20150025113A1,CC(C)c1ccc(C=CC(=O)OCCN2C(=O)C3C4C=C(C(O)(c5ccccc5)c5ccccn5)C(C4=C(c4ccccc4)c4ccccn4)C3C2=O)cc1.CCN=C=NCCCN(C)C.COc1ccc(C=CC(=O)O)cc1>>COc1ccc(C=CC(=O)NCCN2C(=O)C3C4C=C(C(O)(c5ccccc5)c5ccccn5)C(C4=C(c4ccccc4)c4ccccn4)C3C2=O)cc1,,ClCCl,,CCN(CC)CC,CN(C)c1ccccn1,val
US04429152,CCOC(=O)CBr.N#Cc1c(Cl)cc(Cl)c(O)c1Cl>>COC(=O)COc1c(Cl)cc(Cl)c(C#N)c1Cl,,CO,,[Na],,val
US20050026935A1,CCOC(=O)c1c(-c2ccccc2)csc1N.N#CCCl>>O=c1[nH]c(CCl)nc2scc(-c3ccccc3)c12,,C1COCCO1,O,Cl,O=C([O-])O.[Na+],val
US20030087902A1,CCOC(=O)c1c(-c2cccc(OCC3CC3)c2)c2cc(OCC=O)ccc2n1Cc1cccc(OC)c1>>CCOC(=O)c1c(-c2cccc(OCC3CC3)c2)c2cc(OCCO)ccc2n1Cc1cccc(OC)c1,,CO,,[BH4-].[Na+],,val
US20040220186A1,CC(C)c1n[nH]c2c(=O)[nH]c(C[C@@H]3CCCC[C@H]3N=[N+]=[N-])nc12>>CC(C)c1n[nH]c2c(=O)[nH]c(C[C@@H]3CCCC[C@H]3N)nc12,[Pd],CCO,,Cl,[H][H],val
US20090197863A1,CCOC(=O)c1cccc(N)c1O.O=C(Cl)C1CCCN1C(=O)OCc1ccccc1>>COC(=O)c1cccc(NC(=O)C2CCCN2C(=O)OCc2ccccc2)c1O,,ClCCl,,c1ccncc1,,val
US20140121187A1,CC(=O)c1cccc(O)c1.O=C1c2ccccc2C(=O)C1(O)O>>CC(=O)c1ccc(C2(O)C(=O)c3ccccc3C2=O)c(O)c1,,CC(=O)O,ClCCl,,,val
US06200933B1,COc1cc(C#N)nc(Oc2cccc(OC(F)(F)F)c2)c1.O.O>>COc1cc(Oc2cccc(OC(F)(F)F)c2)nc(C(=O)O)c1,,Cl,,CCOC(C)=O,,val
US20050277674A1,CN(C)C1(c2ccc(F)cc2)CCC(=CC(=O)N2CCC(c3c[nH]c4ccccc34)C2)CC1.C[Si](C)(C)Cl>>CN(C)C1(c2ccc(F)cc2)CCC(=CC(=O)N2CCC(c3c[nH]c4ccccc34)C2)CC1.Cl,,CCC(C)=O,,,,val
US08735584B2,O=C(Cl)c1ccc(F)cc1C(F)(F)F.O=c1[nH]c2nccc(Oc3ccc4c(c3)OCCN4)c2c2ccccc12>>O=C(c1ccc(F)cc1C(F)(F)F)N1CCOc2cc(Oc3ccnc4[nH]c(=O)c5ccccc5c34)ccc21,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20100324106A1,Fc1c(OCc2ccccc2)ccc(-n2ccc3c(OCc4ccccc4)cccc32)c1F>>Oc1ccc(-n2ccc3c(O)cccc32)c(F)c1F,[Pd],CCOC(C)=O,,,,val
US20080108624A1,CC(C)(C)OC(=O)N1CCC(CC2CCNCC2)CC1.N#CC(O)C1CC1>>CC(C)(C)OC(=O)N1CCC(CC2CCN(CC3CC3)CC2)CC1,,ClCCl,,CCN(CC)CC,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05883102,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.N#Cc1ccc(C(=O)N2CCC3(CC2)OCCO3)cc1>>N#Cc1ccc(C(=S)N2CCC3(CC2)OCCO3)cc1,,C1COCCO1,,,,val
US20090036684A1,COc1cc(OC)c(C(=O)O)cc1Cc1cccc(Cl)c1F.O=S(Cl)Cl>>COc1cc(OC)c(C(=O)Cl)cc1Cc1cccc(Cl)c1F,,CN(C)C=O,Cc1ccccc1,,,val
US04036913,NS(N)(=O)=O.O=Cc1ccccc1.c1ccc(OP(Oc2ccccc2)Oc2ccccc2)cc1>>NS(=O)(=O)NC(c1ccccc1)P(=O)(Oc1ccccc1)Oc1ccccc1,,Clc1ccccc1,,,,val
US20060235029A1,CC1(C)OB(c2ccc(C(=O)O)cc2)OC1(C)C.CCN(CC)CCCNc1nc(Cl)c2ccc(=O)n(-c3c(F)cccc3F)c2n1>>CCN(CC)CCCNc1nc(-c2ccc(C(=O)O)cc2)c2ccc(=O)n(-c3c(F)cccc3F)c2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20150045359A1,C#Cc1ccc([C@H]2CN(C(=O)OC(C)(C)C)CCO2)cc1.[N-]=[N+]=Nc1ccc(F)cc1>>CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(-c3cn(-c4ccc(F)cc4)nn3)cc2)C1,[Cu]I,CCN(C(C)C)C(C)C,,,,val
US05236931,NC1CN2CCC1CC2.Nc1cc(OCc2cccc(Cl)c2)c(C(=O)O)cc1Cl>>Nc1cc(OCc2cccc(Cl)c2)c(C(=O)NC2CN3CCC2CC3)cc1Cl,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US04956462,CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1.OCc1cc(S)n2nc(CO)nc2n1>>NC1C(=O)N2C(C(=O)O)=C(CSc3cc(CO)nc4nc(CO)nn34)CS[C@H]12,,CC#N,,N,O,val
US20100120739A1,CO.O=C(O)Cc1cc2cccnc2cc1F>>COC(=O)Cc1cc2cccnc2cc1F,,CCOC(C)=O,,O=S(=O)(O)O,,val
US06300353B1,Cc1cc(C=O)cc(C)c1OC(=O)CNCC(=O)OC(C)(C)C>>Cc1cc(CO)cc(C)c1OC(=O)CNCC(=O)OC(C)(C)C,,C1CCOC1,CCOC(C)=O,[BH4-].[Na+],,val
US20150322008A1,CC(C)CB(O)O.COC(=O)c1cc(I)c(N)cc1Cl>>COC(=O)c1cc(CC(C)C)c(N)cc1Cl,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,O,,,val
US20100234378A1,C#CC(C)(C)NS(=O)(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1.ClCCN1CCOCC1>>C#CC(C)(C)N(CCN1CCOCC1)S(=O)(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20020114770A1,CC(C)(C)[Si](C)(C)Oc1ccc([C@H]2CC[C@@H](NCc3ccccc3)CC2)c(O[Si](C)(C)C(C)(C)C)c1>>CC(C)(C)[Si](C)(C)Oc1ccc([C@@H]2CC[C@H](N)CC2)c(O[Si](C)(C)C(C)(C)C)c1,[Pd],CCO,,,,val
US04387101,CCOC(=O)C(Cl)c1ccc(C)c(C)c1.NC(N)=S.O>>Cc1ccc(C2SC(=O)NC2=O)cc1C,,CCOCCO,,Cl,,val
US20120295884A1,CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1C(=O)N[C@H](CO)c1cccc(Cl)c1F.CI>>COC[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)OC(C)(C)C)c1cccc(Cl)c1F,,C1CCOC1,ClCCl,[H-].[Na+],,val
US20120101127A1,Cc1ccc2c(c1)C(C)(C)CC(c1ccccc1N)N2.O=S(=O)(Cl)c1ccccc1>>Cc1ccc2c(c1)C(C)(C)CC(c1ccccc1NS(=O)(=O)c1ccccc1)N2,,ClCCl,O,c1ccncc1,,val
US20050096380A1,CCOC(=O)/C=C(C)/C=C/C(F)=C(/CC)c1cc2c(cc1OCC)C(C)(C)CC=C2CC>>CCOc1cc2c(cc1/C(CC)=C(F)\C=C\C(C)=C\C(=O)O)C(CC)=CCC2(C)C,,CCO,,[Na+].[OH-],,val
US04326087,O=C(F)c1ccc(F)c(Br)c1>>OCc1ccc(F)c(Br)c1,,CC(C)O,,Cl,[BH4-].[Na+],val
US20150210739A1,CC(C)(C)OC(=O)N[C@H](C(=O)O)C1CCCCC1.O=C(Nc1c(F)cccc1F)[C@H]1NCc2ccccc21>>CC(C)(C)OC(=O)N[C@H](C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F)C1CCCCC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130116246A1,Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2C=O)cc(Nc2cc3n(n2)CCOC3)c1=O>>Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(Nc2cc3n(n2)CCOC3)c1=O,,CO,,[BH4-].[Na+],,val
US20040242668A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(N)Cc1c[nH]c2c(OCc3ccccc3)cccc12>>CC(C)(Cc1c[nH]c2c(OCc3ccccc3)cccc12)NC(=O)OC(C)(C)C,,O,,CCN(CC)CC,ClCCl,val
US20090247519A1,CC(C)(C)OC(=O)NCCNc1nc(-c2ccccc2O)nc2cc(Cl)ccc12.OB(O)c1ccccc1>>NCCNc1nc(-c2ccccc2O)nc2cc(-c3ccccc3)ccc12,,CCCCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20030163876A1,Nc1nc(Cl)ccc1[N+](=O)[O-].OC1CCNC1>>Nc1nc(N2CCC(O)C2)ccc1[N+](=O)[O-],,O,,C1COCCO1,,val
US20010034343A1,COC(=O)c1ccc(O)cc1OC.COCCCl>>COCCOc1ccc(OC)c(C(=O)OC)c1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04543360,COc1cc(Cl)c(-c2cc3c(Cl)cc(OC)cc3n2C)c(Cl)c1>>Cn1c(-c2c(Cl)cc(O)cc2Cl)cc2c(Cl)cc(O)cc21,,O,,BrB(Br)Br,,val
US20120184553A1,Cn1cc(-c2ccc(OCc3ccc(F)cc3)c(C(=O)OCc3ccc(F)cc3)c2)cn1>>Cn1cc(-c2ccc(OCc3ccc(F)cc3)c(C(=O)O)c2)cn1,,C1CCOC1,O,[Li+].[OH-],,val
US20050272669A1,CC(=O)OC[C@H]1O[C@@H](Oc2n[nH]c(C(C)C)c2Cc2ccc(OCCCOS(C)(=O)=O)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.CC(C)(N)C(=O)NCCO>>CC(=O)OC[C@H]1O[C@@H](Oc2n[nH]c(C(C)C)c2Cc2ccc(OCCCNC(C)(C)C(=O)NCCO)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,CC#N,CCO,[I-].[Na+],,val
US04342780,COc1ccc(CC(=O)CF)cc1OC.N.[C-]#N>>COc1ccc(CC(N)(C#N)CF)cc1OC,,N,,[Cl-].[NH4+],,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4cncn4C)cc2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4cncn4C)cc2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20070004710A1,COc1ccc2nccc(-c3ccc(CC#N)cn3)c2n1>>COc1ccc2nccc(-c3ccc(CCN)cn3)c2n1,,C1CCOC1,,B,,val
US20130150359A1,COc1cc2ncc([N+](=O)[O-])c(C(=O)c3ccc(C#N)cc3)c2cc1OCc1ccccc1>>COc1cc2ncc(N)c(C(=O)c3ccc(C#N)cc3)c2cc1OCc1ccccc1,[Fe],CCOC(C)=O,CO,Cl,,val
US20110136763A1,CC(C)(C)OC(=O)c1cnc(Cl)s1.CCOC(=O)CC1OB(O)c2cc(O)cc(C)c21>>CCOC(=O)CC1OB(O)c2cc(Oc3ncc(C(=O)OC(C)(C)C)s3)cc(C)c21,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20030060474A1,CCOC(=O)N1CCN(C(=O)C(CCC(=O)OCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)OC(C)(C)C)c3ccccc3n2)CC1>>CCOC(=O)N1CCN(C(=O)C(CCC(=O)OCC(=O)O)NC(=O)c2cc(OCC(=O)O)c3ccccc3n2)CC1,,ClCCl,O,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US05733913,CN1CCN(CCCNc2ncc3cc(-c4c(Cl)cccc4Cl)c(N)nc3n2)CC1.COc1cccc(N=C=O)c1>>COc1cccc(NC(=O)Nc2nc3nc(NCCCN4CCN(C)CC4)ncc3cc2-c2c(Cl)cccc2Cl)c1,,CC#N,CO,,,val
US20060241128A1,CC(C)N.Fc1cc(F)c(F)c(-c2c(Cl)nc3ncnn3c2Cl)c1>>CC(C)Nc1c(-c2cc(F)cc(F)c2F)c(Cl)nc2ncnn12,,ClCCl,,CCN(CC)CC,,val
US04994465,O=C=Nc1ccc(F)cc1F.c1ccc(CNCC(c2ccccc2)c2ccccc2)cc1>>O=C(Nc1ccc(F)cc1F)N(Cc1ccccc1)CC(c1ccccc1)c1ccccc1,,CCOC(C)=O,,,,val
US07030242B2,CC(NCCO)C(NS(=O)(=O)c1ccc(OCc2ccccc2)cc1)C12OCC(C)(CO1)CO2>>CC1NCCN(S(=O)(=O)c2ccc(OCc3ccccc3)cc2)C1C12OCC(C)(CO1)CO2,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04771050,COC(=O)[C@H](C)OC(=O)CN1C(=S)[C@H](C(C)C)Oc2c(C(C)C)cccc21>>CC(C)c1cccc2c1O[C@@H](C(C)C)C(=S)N2CC(=O)O,,CO,,,,val
US20090023724A1,CCO.C[C@@H](Nc1cc(-c2cccc3ncccc23)ncc1N)c1ccccc1.C[C@@H](Nc1cc(-c2cccc3ncccc23)ncc1[N+](=O)[O-])c1ccccc1>>C[C@H](c1ccccc1)n1c(=O)[nH]c2cnc(-c3cccc4ncccc34)cc21,[Pd],,,[H][H],,val
US20060173018A1,CC(C)COC(=O)Cl.Cc1ccc2c(N3CC[C@@H](CN)C3)nc(-c3ccccc3O)nc2c1>>Cc1ccc2c(N3CC[C@@H](CNC(=O)OCC(C)C)C3)nc(-c3ccccc3O)nc2c1,,ClCCl,,C1CCOC1,CCN(CC)CC,val
US20150175619A1,CC(C)NN.CCOC(=O)C(=O)CC(=O)C1C2CC(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)CC21>>CCOC(=O)c1cc(C2C3CC(O[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)CC32)n(C(C)C)n1,,CCO,,CCN(CC)CC,Cl,val
US20120214822A1,CN(C)CCCN.COC(=O)c1ccc(C)c(-n2cc(Cl)nc(Cl)c2=O)c1.NC1CC1>>Cc1ccc(C(=O)NC2CC2)cc1-n1cc(Cl)nc(NCCCN(C)C)c1=O,,C1CCOC1,,CC(C)[Mg]Cl,[Cl-].[NH4+],val
US20110009441A1,COc1ccnc(N)c1C#N.O=CCCl>>N#Cc1c(O)ccn2ccnc12,,CCO,,CCOCC,,val
US05162318,CN(C)CCn1c(=O)[nH]c2ccccc21.Cl>>CN(C)CCn1c(=O)[nH]c2ccccc21.Cl,,C1COCCO1,CCOCC,,,val
US20110071126A1,CON(C)C(=O)c1cccnn1.N#C[Cu]>>CC(O)c1cccnn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,,val
US20160207887A1,Cc1ccc(S(=O)(=O)OCCC(C)(O)C(F)(F)S(=O)(=O)c2ccccc2)cc1.Oc1ccc(Br)cc1>>CC(O)(CCOc1ccc(Br)cc1)C(F)(F)S(=O)(=O)c1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04145433,COC(=O)N=C(NC(=O)OC)SC.Nc1ccc(S(=O)Cc2ccccc2)cc1N>>COC(=O)Nc1nc2cc(S(=O)Cc3ccccc3)ccc2[nH]1,,CC(=O)O,CO,,,val
US04030908,CC1=CCC(C(C)CC=O)CC1.CNC>>CC1=CCC(C(C)CCN(C)C)CC1,O=[Pt],CCO,,[H][H],,val
US20070105832A1,CC(C)[Si](S)(C(C)C)C(C)C.CCOC(=O)[C@@H]1[C@H](OS(=O)(=O)C(F)(F)F)C(=O)N1c1ccc(OC)cc1>>CCOC(=O)[C@@H]1[C@@H](S)C(=O)N1c1ccc(OC)cc1,,C1CCOC1,,[H-].[Na+],,val
US20050256107A1,COC(=O)C(C)N.O=C(O)c1ccc(Cl)s1>>COC(=O)C(C)NC(=O)c1ccc(Cl)s1,,C1CCOC1,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US04622318,C#Cc1cccnc1.SC(c1ccccc1)(c1ccccc1)c1ccccc1>>C(=C\c1cccnc1)\SC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20020022729A1,CN.O=C(Cl)c1cc(Cl)sc1Cl>>CNC(=O)c1cc(Cl)sc1Cl,,ClCCl,,,,val
US20130184284A1,OC1CCCN(c2ccc(I)cc2)C1.c1nc[nH]n1>>OC1CCCN(c2ccc(-n3cncn3)cc2)C1,[Cu]I,CN(C)C=O,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20160108039A1,CC1(CO)COC(C)(C)CN1.COc1cc(C(=O)O)cn2nc(NCc3cccc(Cl)c3)nc12>>COc1cc(C(=O)N2CC(C)(C)OCC2(C)CO)cn2nc(NCc3cccc(Cl)c3)nc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050192347A1,CC(CO)(CCCCBr)c1ccccc1.O=C1NC(=O)c2ccccc21>>CC(CO)(CCCCN1C(=O)c2ccccc2C1=O)c1ccccc1,,CN(C)C=O,O,[K],,val
US20090062317A1,CC(C)(C)OC(=O)N1CCN(CCCNc2nc(-c3ccc(Cl)cc3)c3ccccc3n2)CC1>>Clc1ccc(-c2nc(NCCCN3CCNCC3)nc3ccccc23)cc1,,ClCCl,,,,val
US20160009712A1,CC(C)Nc1ncc(Br)cc1N.O=N[O-]>>CC(C)n1nnc2cc(Br)cnc21,,Cl,O,[Na+].[OH-],,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4cncc(Br)c4nn23)CC1.Cl>>Cl.O=c1cc(C2CCNCC2)n2nc3c(Br)cncc3c2[nH]1,,C1COCCO1,CO,,,val
US07250410B2,CCN1C(=O)CN=C(c2ccc(-c3ccccc3)cc2)c2cc(OC)c(OC)cc21.CO.ClCCl>>CCN1C(=O)CN=C(c2ccc(CCc3ccccc3)cc2)c2cc(OC)c(OC)cc21,[Pd],CO,ClCCl,,,val
US20100216860A1,CC(C)(C)N(Cc1ccc(CO)cc1)C(=O)[O-].COc1cccc2[nH]nc(N(S(=O)(=O)c3ccc(Cl)s3)S(=O)(=O)c3ccc(Cl)s3)c12>>COc1cccc2c1c(N(S(=O)(=O)c1ccc(Cl)s1)S(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CNC(=O)OC(C)(C)C)cc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030092695A1,CC(C)(C)[Si](C)(C)OCCCCCCBr.CCCCCC>>C#CCCCCCCO[Si](C)(C)C(C)(C)C,,C1CCOC1,CS(C)=O,CCOC(C)=O,,val
US20080027076A1,Nc1cccc(C#Cc2c(N)ncnc2N)c1.O=C=Nc1ccccc1>>Nc1ncnc(N)c1C#Cc1cccc(NC(=O)Nc2ccccc2)c1,,C1CCOC1,,,,val
US20070032485A1,CCOC(=O)N1c2ccc(OC)nc2[C@H](N)C[C@@H]1CC.Clc1ncc(Br)cn1>>CCOC(=O)N1c2ccc(OC)nc2[C@H](Nc2ncc(Br)cn2)C[C@@H]1CC,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US05096890,NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(CCc2ccc3occc3c2)C1>>NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(CCc2ccc3c(c2)CCO3)C1,[Pd],CC(=O)O,,,,val
US20020002283A1,CNN.COC(=O)C1(Cc2ccccc2)CN(C(=O)OC(C)(C)C)CCC1=O>>CN1N=C2CCN(C(=O)OC(C)(C)C)CC2(Cc2ccccc2)C1=O,,COC(C)(C)C,O,CC(=O)O,O=C([O-])O.[Na+],val
US20030087926A1,C=Cc1cccc(Br)c1.CCC(=O)C(=O)[O-].Nc1cc(Cl)cc(Cl)c1>>CCOC(=O)C1CC(c2cccc(Br)c2)c2c(Cl)cc(Cl)cc2N1,,CC#N,,O=C(O)C(F)(F)F,,val
US20150232429A1,C[Si](C)(C)C#CN1CCOCC1.[N-]=[N+]=Nc1ccc([N+](=O)[O-])cc1>>C[Si](C)(C)c1nnn(-c2ccc([N+](=O)[O-])cc2)c1N1CCOCC1,,Cc1ccccc1,,,,val
US20150307497A1,CO.O=C(O)c1c(I)ccnc1F>>COC(=O)c1c(I)ccnc1F,,CCOCC,,C[Si](C)(C)C=[N+]=[N-],,val
US20160152561A1,NS(=O)(=O)c1cccc(NC(=O)c2cc(Br)c(Cl)cc2F)c1.Oc1ccc(F)cc1>>NS(=O)(=O)c1cccc(NC(=O)c2cc(Br)c(Cl)cc2Oc2ccc(F)cc2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090312314A1,Cn1c(=O)n(C)c2cc([N+](=O)[O-])ccc21.N#CCc1ccc(C(F)(F)F)nc1>>Cn1c(=O)n(C)c2cc(NCCc3ccc(C(F)(F)F)nc3)ccc21,[Pd],CO,,,,val
US20090197859A1,Cc1ccccc1C1CCN(S(=O)(=O)c2cccc(N3CCN(C)CC3)n2)CC1.Cl>>Cc1ccccc1C1CCN(S(=O)(=O)c2cccc(N3CCN(C)CC3)n2)CC1.Cl,,CCOCC,ClCCl,,,val
US20130210844A1,CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)O)c1F.CC1(C)CCC(Oc2nccc3c(N)cccc23)CC1>>CC1(C)CCC(Oc2nccc3c(NC(=O)c4c(Cl)ccc(CNC(=O)C(C)(C)C)c4F)cccc23)CC1,CN(C)C=O,ClCCl,,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20090042852A1,CCOC(=O)c1cc(C#N)c(Cl)nc1C.O=C(NS(=O)(=O)c1ccc(Cl)s1)C1CCNCC1>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)c3ccc(Cl)s3)CC2)nc1C,,CC(=O)N(C)C,CCOC(C)=O,CCN(C(C)C)C(C)C,Cl,val
US04885297,CC(=O)OC(C)=O.O=C(Cn1c(=O)sc2ncc(Cl)cc21)N1CCN(CCO)CC1>>CC(=O)OCCN1CCN(C(=O)Cn2c(=O)sc3ncc(Cl)cc32)CC1,,c1ccncc1,,,,val
US20100099695A1,C=CC[C@@H]1CCCC[C@H]1O.COC(=O)[C@@H]1C[C@@H](N)CN1C(=O)OC(C)(C)C.O=C(n1ccnc1)n1ccnc1>>C=CCC1CCCCC1OC(=O)N[C@@H]1C[C@@H](C(=O)OC)N(C(=O)OC(C)(C)C)C1,,CN(C)C=O,,,,val
US05506235,COc1ccc2nccc(Cl)c2c1>>Oc1ccc2nccc(Cl)c2c1,,O,,Br,[Na+].[OH-],val
US20090118327A1,CNC1=NCC(c2ccc([N+](=O)[O-])cc2)c2cc(Cl)ccc21>>CNC1=NCC(c2ccc(N)cc2)c2cc(Cl)ccc21,[Fe],CC(=O)O,,Cl,,val
US05149773,O=c1cnc2ccccc2[nH]1>>c1ccc2c(c1)NCCN2,,C1CCOC1,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20080293951A1,CCCN(CCC)CCCCNCc1ccc(CN)cc1>>CCCN(CCC)CCCCNCc1ccc(CN)cc1,,O,,Cl,[Na+].[OH-],val
US20070043010A1,Oc1ncnc2cc(OCc3ccccc3)ccc12>>Oc1ccc2c(O)ncnc2c1,[Pd],CN(C)C=O,O,O=C[O-].[NH4+],,val
US20100081690A1,O=C(OCc1ccccc1)N1CCC[C@H](c2nc(-c3cc(F)c[nH]3)co2)C1>>Fc1c[nH]c(-c2coc([C@H]3CCCNC3)n2)c1,[Pd],CO,,O=C[O-].[NH4+],,val
US20110269956A1,C#C[Si](C)(C)C.CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1ncc(I)[nH]1>>CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1ncc(C#C[Si](C)(C)C)[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,CCN(CC)CC,,val
US20160039838A1,O=[N+]([O-])c1cc2c(Nc3ccc(OCc4ccccn4)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1>>Nc1cc2c(Nc3ccc(OCc4ccccn4)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1,[Fe],CCO,,Cl,[Na+].[OH-],val
US20120108619A1,CC(C)(C)OC(=O)N1[C@H]2CC[C@@H]1CC(C(=O)O)C2.CI>>COC(=O)C1C[C@@H]2CC[C@H](C1)N2C(=O)OC(C)(C)C,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20080039459A1,BrP(Br)Br.O=Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1>>Clc1nc(N2CCOCC2)c2sc(CBr)cc2n1,,Cc1ccccc1,ClCCl,,,val
US20070117800A1,OCc1cccc(Nc2nccc(-c3ccc(Br)s3)n2)c1>>O=Cc1cccc(Nc2nccc(-c3ccc(Br)s3)n2)c1,O=[Mn]=O,,,,,val
US04866091,CS(=O)(=O)Nc1ccc(C(=O)O)cc1Oc1ccc(F)cc1F.ClP(Cl)(Cl)(Cl)Cl>>CS(=O)(=O)Nc1ccc(C(=O)Cl)cc1Oc1ccc(F)cc1F,,c1ccccc1,,,,val
US20050014782A1,Fc1ccc(SCCCBr)cc1.Fc1ccc2c(c1)nc(C1CC1)n2C1CC2CCC(C1)N2>>Fc1ccc(SCCCN2C3CCC2CC(n2c(C4CC4)nc4cc(F)ccc42)C3)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20150252057A1,CC(C)(CO)CCCN1CC2CN(C(=O)OC(C)(C)C)CCN2C1=O>>CC(C)(CO)CCCN1CC2CNCCN2C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150252030A1,COC(=O)COc1c(C)cc(C)cc1-c1cccs1.NN>>Cc1cc(C)c(OCC(=O)NN)c(-c2cccs2)c1,,CCO,,,,val
US04686230,CO.Cc1ccc(O)cn1>>COc1ccc(C)nc1,,CS(C)=O,,[K+].[OH-],,val
US20090298807A1,CCCCc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(CCO[Si](C)(C)C(C)(C)C)c4F)CC3)C2)cs1>>CCCCc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(CCO)c4F)CC3)C2)cs1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100280009A1,Br[Mg]c1ccccc1.O=C1CCN(C(=O)OCc2ccccc2)C(c2ccccc2)C1>>O=C(OCc1ccccc1)N1CCC(O)(c2ccccc2)CC1c1ccccc1,,C1CCOC1,,,,val
US04150240,CC(C)(S)[C@@H](N)C(=O)O>>CC(C)(S)[C@@H](N)C(=O)O,,CCO,,Cl,,val
US20080015199A1,COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(OC)c2c(c1F)CCCO2.NNc1ncccn1>>COc1cc(C(Nc2ccc(-c3noc(C)n3)cc2)c2nn(-c3ncccn3)c(=O)[nH]2)c(F)c2c1OCCC2,,CN(C)C=O,,CCN(CC)CC,,val
US20050267049A1,CC(C)(C)[Si](C)(C)Oc1ccc([C@@H]2[C@@H](CC[C@H](O)c3ccc(F)cc3)C(=O)N2c2ccc(C#CCNS(C)(=O)=O)cc2)cc1>>CS(=O)(=O)NCC#Cc1ccc(N2C(=O)[C@H](CC[C@H](O)c3ccc(F)cc3)[C@H]2c2ccc(O)cc2)cc1,,C1CCOC1,,Cl,,val
US20050215772A1,CC1(O)OC(=O)C=C1c1ccccc1.Nc1ccccc1>>CC1(Nc2ccccc2)OC(=O)C=C1c1ccccc1,,Cc1ccccc1,,,,val
US20130109708A1,COc1cc(C(=O)[O-])ccc1COc1cnc(OCC(C)C)c(Cl)c1>>COc1cc(C(=O)O)ccc1COc1cnc(OCC(C)C)c(Cl)c1,,CO,,[Li+].[OH-],,val
US04698337,Cl.NC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCCOC=O)c3csc(NC=O)n3)[C@H]2SC1>>Cl.NC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCCO)c3csc(N)n3)[C@H]2SC1,,CO,,C1CCOC1,,val
US20140018533A1,Cc1cc(CN(C)C)ccc1[N+](=O)[O-]>>Cc1cc(CN(C)C)ccc1N,[Pd],CCO,,,,val
US20110224208A1,COCCCN1C(=O)c2ccccc2C(C(=O)O)C1c1cccs1.COc1cccc(N)c1>>COCCCN1C(=O)c2ccccc2C(C(=O)Nc2cccc(OC)c2)C1c1cccs1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130005705A1,N#Cc1ccc(B(O)O)s1.O=C1c2c(Br)cccc2CN1CCc1ccc2ccccc2n1>>N#Cc1ccc(-c2cccc3c2C(=O)N(CCc2ccc4ccccc4n2)C3)s1,,C1COCCO1,,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],val
US20150152088A1,CN1CCN(Cc2ccc(N)cc2C(F)(F)F)CC1.Cc1ccc(N)cc1I.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1ccc(NC(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1I,,ClCCCl,,CCN(CC)CC,,val
US20030186969A1,CC(C)=O.O=C(O)C(F)(F)F.O=C(c1ccc(Cl)cc1)N1CC(=O)N(CC2CCNCC2)c2ccccc2C1>>CC(C)N1CCC(CN2C(=O)CN(C(=O)c3ccc(Cl)cc3)Cc3ccccc32)CC1.O=C(O)C(F)(F)F,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04788197,COc1cccc(C=O)c1.c1ccc(C2=NCCN=C2c2ccccc2)cc1>>COc1cccc(Cc2cnc(-c3ccccc3)c(-c3ccccc3)n2)c1,,CO,O,,,val
US20120258946A1,COc1c(Cl)cccc1-n1nc(C(F)(F)F)cc1I.N#C[Cu]>>COc1c(Cl)cccc1-n1nc(C(F)(F)F)cc1C#N,,CN1CCCC1=O,,,,val
US04025652,CN=C(NC(N)=O)Nc1c(C)cccc1C>>CN=C(NC(N)=O)Nc1c(C)cccc1C,,[Na+],[OH-],Cl,,val
US04544655,COC(=O)CNS(=O)(=O)c1cc(C(F)(F)F)sc1C(=O)OC>>COC(=O)C1=C(O)c2sc(C(F)(F)F)cc2S(=O)(=O)N1,,C1CCOC1,,,,val
US20160168100A1,COc1ccc(CCNC(=O)/C=C/c2cc(OCc3ccccc3)c(OC)cc2C(C)(C)C)cc1OCc1ccccc1>>COc1cc(C(C)(C)C)c(/C=C/C2=NCCc3cc(OCc4ccccc4)c(OC)cc32)cc1OCc1ccccc1,,CC#N,,O=P(Cl)(Cl)Cl,,val
US20080207654A1,CC(C)OC(=O)N=NC(=O)OC(C)C.CC1(C)CC(O)CCO1.CCCc1nc(C)n(-c2ccc(O)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1>>CCCc1nc(C)n(-c2ccc(OC3CCOC(C)(C)C3)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04038396,Nc1ccc[nH]c1=O.O=C(Cl)c1ccccc1F>>O=C(Nc1ccc[nH]c1=O)c1ccccc1F,,c1ccncc1,,,,val
US20160083387A1,CC(=O)OC[C@H]1C[C@@H](OC(C)=O)CC[C@]1(C)[C@H]1CCC2=C(C[C@@H](O)C2(C)C)[C@@H]1CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C>>CC(=O)OC[C@H]1C[C@@H](OC(C)=O)CC[C@]1(C)[C@H]1CCC2=C(C[C@@H](O)C2(C)C)[C@@H]1CO,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090137609A1,CCC(CC)(c1ccc(/C=C/C(O)(C(F)(F)F)C(F)(F)F)c(C)c1)c1ccc(B2OC(C)(C)C(C)(C)O2)c(C)c1.CCOC(=O)Cc1csc(Br)n1>>CCOC(=O)Cc1csc(-c2ccc(C(CC)(CC)c3ccc(/C=C/C(O)(C(F)(F)F)C(F)(F)F)c(C)c3)cc2C)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20080188527A1,CC(=O)CCl.NC(=S)c1cccnc1>>Cc1csc(-c2cccnc2)n1,,CCO,,,,val
US20120190695A1,C[C@H](NS(=O)C(C)(C)C)c1cccc(-c2noc(C(C)(C)O)n2)c1.Cl>>C[C@H](N)c1cccc(-c2noc(C(C)(C)O)n2)c1.Cl,,C1COCCO1,CO,CCOCC,,val
US20030166664A1,Cc1ccc([N+](=O)[O-])cc1CC(=O)N1CCC(c2c[nH]c3c(Cl)cccc23)CC1>>Cc1ccc(N)cc1CC(=O)N1CCC(c2c[nH]c3c(Cl)cccc23)CC1,[Fe],CCO,,Cl,,val
US20120309796A1,CI.CSc1cccc(-c2ccc(S(=O)(=O)NC3CCCCc4c(OCC(=O)OC(C)(C)C)cccc43)cc2)c1>>CSc1cccc(-c2ccc(S(=O)(=O)N(C)C3CCCCc4c(OCC(=O)OC(C)(C)C)cccc43)cc2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060004017A1,COc1cc2c(Cl)ncnc2cc1OCCCN1CCCCC1.Oc1ccc2cc(F)cnc2c1>>COc1cc2c(Oc3ccc4cc(F)cnc4c3)ncnc2cc1OCCCN1CCCCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050203081A1,CC(C)(C)OC(=O)CBr.CCOC(=O)c1sc2nc(OCc3ccccc3)ccc2c1O>>CCOC(=O)c1sc2nc(OCc3ccccc3)ccc2c1OCC(=O)OC(C)(C)C,,CN(C)C=O,O,[H-].[Na+],,val
US20100292222A1,CS(=O)(=O)OCCOc1ccc(C2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1.O=C1CNCCN1C1CC1>>O=C1CN(CCOc2ccc(C3CCN(c4ccc5nnc(C(F)(F)F)n5n4)CC3)cc2)CCN1C1CC1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US06043357,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O.CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)NCCCBr>>CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)NCCCBr,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080019915A1,Cc1ccc(N)nc1Cl.O=C(Cl)C1(c2ccc3c(c2)OC(F)(F)O3)CC1>>Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1Cl,,ClCCl,,CCN(CC)CC,,val
US20100305122A1,COCCOCCS.NS(=O)(=O)c1ccc(F)c(Cl)c1>>COCCOCCSc1ccc(S(N)(=O)=O)cc1Cl,,C1CCOC1,,O,[H-].[Na+],val
US20050038071A1,CCCCCCC1C=C(Cl)C=CN1C(=O)OC(C)(C)C.CI>>CCCCCCC1C=C(Cl)C=C(C)N1C(=O)OC(C)(C)C,,C1CCOC1,CCOCC,O,[Li]CCCC,val
US20120142671A1,N#Cc1cc(F)c(F)cc1Br.NC(=O)C(N)CC(F)(F)F>>N#Cc1cc(F)c(NC(CC(F)(F)F)C(N)=O)cc1Br,,CCOC(C)=O,CS(C)=O,CCN(C(C)C)C(C)C,O,val
US20110136762A1,COc1cncc(C2=C(c3c(F)cc(F)cc3F)C(=O)OC2(O)c2ccccc2F)c1.NN>>COc1cncc(-c2c(-c3ccccc3F)n[nH]c(=O)c2-c2c(F)cc(F)cc2F)c1,,CCO,,O,,val
US20110230403A1,CCOc1ccc(Cc2cc([C@@H]3O[C@H](COc4cccc([N+](=O)[O-])c4)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1>>CCOc1ccc(Cc2cc(C3OC(COc4cccc(N)c4)C(O)C(O)C3O)ccc2Cl)cc1,[Pd],,,,,val
US04061761,C=[N+]=[N-].CCCCN(CCCC)S(=O)(=O)c1cc(C(=O)Cl)ccc1Cl.Cl>>CCCCN(CCCC)S(=O)(=O)c1cc(C(=O)CCl)ccc1Cl,,COCCOCCOC,,CCOCC,,val
US08506655B1,CCN1c2cc(P(=O)(O)c3ccc4c(c3)N(CC)C(C)(C)C=C4C)ccc2C(C)=CC1(C)C>>CCN1c2cc(P(=O)(O)c3ccc4c(c3)N(CC)C(C)(C)CC4C)ccc2C(C)CC1(C)C,[Pt],CO,,,,val
US05342846,C[C@H]1COc2c(F)c(F)cc3c(=O)c(C(=O)O)cn1c23.c1ncn(C2CCNC2)n1>>C[C@H]1COc2c(N3CCC(n4cncn4)C3)c(F)cc3c(=O)c(C(=O)O)cn1c23,,CC#N,,C1CCC2=NCCCN2CC1,Cl,val
US20050107364A1,CC(C)(C)OC(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(C1=C(O)c3ccccc3C(C)(CCCC3CCCCC3)C1=O)N2.Cl>>CC1(CCCC2CCCCC2)C(=O)C(C2=NS(=O)(=O)c3cc(N)ccc3N2)=C(O)c2ccccc21.Cl,,C1COCCO1,,,,val
US20100099715A1,Cc1cc(Br)cc(C)n1.Oc1ccc(Br)cc1F>>Cc1cc(Oc2ccc(Br)cc2F)cc(C)n1,,CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120108627A1,CC(C)(C#N)c1ccc(-n2c(=O)[nH]c3cnc4ccc(Br)cc4c32)cc1.Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)Cl>>Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)n1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(Br)ccc3ncc21,,ClCCl,,CCN(CC)CC,O,val
US20100179154A1,CC(C)(C)OC(=O)N1CCN(c2ccc3nc(-c4ccc(F)cc4)c(-c4ccnc(N=C(c5ccccc5)c5ccccc5)c4)n3n2)CC1>>Nc1cc(-c2c(-c3ccc(F)cc3)nc3ccc(N4CCNCC4)nn23)ccn1,,Cl,,,,val
US20030087905A1,Nc1cccc(Oc2ccccc2)c1.O=Cc1cccc(OCC(F)(F)F)c1>>FC(F)(F)COc1cccc(CNc2cccc(Oc3ccccc3)c2)c1,,C1CCCCC1,,[BH4-].[Na+],,val
US20150368245A1,CNC[C@@H]1CC[C@@H](N2CN(C)C(=O)c3cnc4c(ccn4COCC[Si](C)(C)C)c32)CC1.CS(=O)(=O)Cl>>CN1CN([C@@H]2CC[C@@H](CN(C)S(C)(=O)=O)CC2)c2c(cnc3c2ccn3COCC[Si](C)(C)C)C1=O,,ClCCl,,CCN(C(C)C)C(C)C,[Cl-].[NH4+],val
US04122260,CC(=O)OCC1=C(C(=O)O)N2C(=O)C(N)C2SC1.O=Cc1cccn1C(C(=O)Cl)S(=O)(=O)O>>CC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(n3cccc3C=O)S(=O)(=O)O)C2SC1,,CCOCC,O,O=C([O-])O.[Na+],,val
US20150274704A1,CC(C)(C)OC(=O)N1CCCC2(CCC(O)C2)C1>>CC(C)(C)OC(=O)N1CCCC2(CCC(=O)C2)C1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20080312208A1,CCc1cnc(-c2cnc(N3CCC(C(=O)OC)CC3)c(Cl)c2SC)o1.O=C(OO)c1cccc(Cl)c1>>CCc1cnc(-c2cnc(N3CCC(C(=O)OC)CC3)c(Cl)c2S(C)=O)o1,,CN(C)C=O,ClCCl,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20090306103A1,COc1cc2nccc(Oc3ccc(N)c(F)c3)c2cc1OC.O=C(Cl)c1cccn(-c2ccc(F)cc2)c1=O>>COc1cc2nccc(Oc3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)c(F)c3)c2cc1OC,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,,val
US20130064770A1,O=C1c2ccccc2C(=O)N1CCCBr.c1ccc(CN2CCNCC2)cc1>>O=C1c2ccccc2C(=O)N1CCCN1CCN(Cc2ccccc2)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US06103725,ClCCCCBr.c1ccc(Nc2nc3ccccc3s2)cc1>>ClCCCCN(c1ccccc1)c1nc2ccccc2s1,,C1CCOC1,,[H-].[Na+],,val
US20080319005A1,Cc1cc(-n2cnc3cccnc32)ccc1CC(=O)O.Nc1cccc(C(F)(F)F)c1>>Cc1cc(-n2cnc3cccnc32)ccc1CC(=O)Nc1cccc(C(F)(F)F)c1,,CO,ClCCl,,,val
US20040110945A1,COC(=O)Cc1ccc2nc(Nc3cc(Cl)ccc3C)oc2c1F>>Cc1ccc(Cl)cc1Nc1nc2ccc(CC(=O)O)c(F)c2o1,,C1CCOC1,CO,[Na+].[OH-],,val
US05405870,C1COCCO1.CCO.CCOC(=O)OCC.O=C1C[C@H]2C=C(CCCCCOCc3ccccc3)C[C@H]2C1>>CC=CCCCCC.CCC=CCCCC,,C1COCCO1,CC(=O)O,[H-].[Na+],,val
US20090137603A1,Cc1ccc([N+](=O)[O-])c(C(=O)O)c1.N>>Cc1ccc([N+](=O)[O-])c(C(N)=O)c1,,C1CCOC1,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20150119362A1,COC(=O)CCCc1ccc(Nc2cc(-c3cccc(Cl)c3)nc3c2CCC3)cc1>>O=C(O)CCCc1ccc(Nc2cc(-c3cccc(Cl)c3)nc3c2CCC3)cc1,,O,,Cl,[Li+].[OH-],val
US20060074087A1,CCC1c2nccnc2CCN1C(=O)C[C@@H](Cc1cc(F)c(F)cc1F)NC(=O)OC(C)(C)C>>CCC1c2nccnc2CCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F,,CO,,Cl,O=C([O-])O.[Na+],val
US20090270359A1,Cc1n[nH]c(C)c1-c1ccc(C#N)cc1.Fc1ccc(CBr)cc1>>Cc1nn(Cc2ccc(F)cc2)c(C)c1-c1ccc(C#N)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20080090854A1,COc1cccc2c(F)cccc12>>Oc1cccc2c(F)cccc12,,ClCCl,,BrB(Br)Br,O,val
US05344843,CCCc1c(OCCCBr)ccc(C(C)=O)c1OC.CCOC(=O)C(=O)c1ccc(O)cc1>>CCCc1c(OCCCOc2ccc(C(=O)C(=O)OCC)cc2)ccc(C(C)=O)c1OC,,CN(C)C=O,,[H-].[Na+],,val
US20020183320A1,Nc1nccs1.O=Cc1ccncc1.[C-]#[N+]c1c(C)cccc1C>>Cc1cccc(C)c1Nc1c(-c2ccncc2)nc2sccn12,,[O-][Cl+3]([O-])([O-])O,,,,val
US20090036441A1,CC(C)N.CCOC(=O)c1c2c(n(C)c1CBr)C(=O)C(=O)c1ccc(Br)cc1-2>>CCOC(=O)c1c2c(n(C)c1CNC(C)C)C(=O)C(=O)c1ccc(Br)cc1-2,,Cc1ccccc1,,,,val
US06420403B1,COc1cc(NC(=O)Nc2cccc([N+](=O)[O-])c2)ccc1-c1cnco1>>COc1cc(NC(=O)Nc2cccc(N)c2)ccc1-c1cnco1,[Pd],C1COCCO1,CO,,,val
US20130210824A1,Cc1ncc2c(I)n[nH]c2n1.Fc1ccccc1CBr>>Cc1ncc2c(I)nn(Cc3ccccc3F)c2n1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04278806,C[Si](C)(C)C#C[Si](C)(C)C.O=C(Cl)CCCCl>>C[Si](C)(C)C#CC(=O)CCCCl,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130059853A1,COc1c(OC(F)F)ccc(-c2cccc3c2CCC3=O)c1O.OCC1(CBr)COC1>>COc1c(OC(F)F)ccc(-c2cccc3c2CCC3=O)c1OCC1(CO)COC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20030092720A1,CC(C)(C)c1csc(NC(=O)c2ccnc(N)c2)n1.O=C([O-])CC(=O)Oc1ccc(Cl)c(Cl)c1Cl>>CC(C)(C)c1csc(NC(=O)C2=CC3=NC(=O)CC(=O)N3C=C2)n1,,Cc1ccccc1C,,,,val
US20100234395A1,COc1ccc(-c2nc(C3(C(=O)OCc4ccccc4)CCN(C(=O)N(C)O)CC3)sc2-c2ccc(OC)cc2)cc1>>COc1ccc(-c2nc(C3(CO)CCN(C(=O)N(C)O)CC3)sc2-c2ccc(OC)cc2)cc1,,C1CCOC1,,O,[BH4-].[Li+],val
US20150239895A1,CC(=O)c1cn(CC(=O)OC(C)(C)C)c2ccc(N3CCN(C(C)=O)CC3)cc12>>CC(=O)c1cn(CC(=O)O)c2ccc(N3CCN(C(C)=O)CC3)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090264429A1,CSc1ccc(C(O)CN=[N+]=[N-])cc1>>CSc1ccc(C(O)CN)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US04595535,Cc1nc(Cc2ccccc2N=C=S)n[nH]1.N#CBr>>Cc1nc2n(n1)C(SC#N)=Nc1ccccc1C2,,C1CCOC1,,O,[H-].[Na+],val
US20100093694A1,COC(=O)c1ccc(N)cc1OC.O=S(=O)(O)O>>COC(=O)c1ccc(O)cc1OC,,ClCCl,,O=N[O-].[Na+],,val
US20020010182A1,Cc1ccc(C[C@@H]2CNCCN2C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1C.Cl.ClCc1ccccn1>>Cc1ccc(C[C@@H]2CN(Cc3ccccn3)CCN2C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1C.Cl.Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05677455,COC(=O)C[C@@H](CC(=O)CP(=O)(OC)OC)O[Si](C)(C)C(C)(C)C.O=Cc1cccnc1>>COC(=O)C[C@@H](CC(=O)/C=C/c1cccnc1)O[Si](C)(C)C(C)(C)C,,CC(C)O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20080096895A1,C1CNCCN1.Clc1ccc(-c2ccccn2)nn1>>c1ccc(-c2ccc(N3CCNCC3)nn2)nc1,,CC#N,,,,val
US05705516,CCN(CC)S(=O)(=O)c1sc(NC(C)=O)nc1C>>CCN(CC)S(=O)(=O)c1sc(N)nc1C,,CO,O,C[O-].[Na+],,val
US20090137609A1,CC(C)(C)C(O)c1cccc(Br)c1.C[Si](C)(C)n1ccnc1>>CC(C)(C)C(O[Si](C)(C)C)c1cccc(Br)c1,,C1CCOC1,,,,val
US04324768,CCCCCCCCCCCCCCCCCC(=O)O.N>>CCCCCCCCCCCCCCCCCC(=O)O.N,,O,,,,val
US05278313,CC(=O)OC[C@@H]1C[C@H](CC(=O)OC(C)(C)C)OC(C)(C)O1>>CC(C)(C)OC(=O)C[C@H]1C[C@@H](CO)OC(C)(C)O1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US04668701,CC1(C)[C@@H](C=C(Br)Br)[C@H]1C(=O)[O-].OCc1ccc(C/C=C\Cl)cc1>>CC1(C)[C@@H](C=C(Br)Br)[C@H]1C(=O)OCc1ccc(C/C=C\Cl)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US03976778,CCN(CC)C(=O)Cl.O=C1NCCN1>>CCN(CC)C(=O)N1CCNC1=O,,CC(C)=O,,,,val
US20130150353A1,C=C1CCC(C(=O)OCC)CC1.CC#N>>C=C1CCC(C(=O)CC#N)CC1,,C1CCOC1,,[Li]CCCC,,val
US20140213586A1,COc1cccc(N)c1.O=C(c1c[nH]c2cc(F)ccc12)C(Cl)c1ccccc1>>COc1cccc(NC(C(=O)c2c[nH]c3cc(F)ccc23)c2ccccc2)c1,,C1COCCO1,CN(C)C=O,CCN(C(C)C)C(C)C,[I-].[Na+],val
US04981850,CC(=N)N.CCOC(=O)c1sc(=S)n(C)c1N>>Cc1nc2c(sc(=S)n2C)c(=O)[nH]1,,CCO,CO,Cl,C[O-].[Na+],val
US20060229280A1,COc1cc(C=O)cc2c1OCO2.C[N+](=O)[O-]>>COc1cc(C=C[N+](=O)[O-])cc2c1OCO2,,CC(=O)O,,C,O=C[O-].[NH4+],val
US05244908,CS(=O)(=O)N1CCC(O)CC1.O=[N+]([O-])c1cnc2cccc(Cl)n12>>CS(=O)(=O)N1CCC(Oc2cccc3ncc([N+](=O)[O-])n23)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US20050054627A1,CCC[C@@H]1C[C@H](NC(=O)OC(C)(C)C)CC[C@@H]1N1CC[C@H](N)C1=O.Clc1ccc2ncnc(Cl)c2c1>>CCC[C@@H]1C[C@H](NC(=O)OC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(Cl)cc23)C1=O,,CCO,,CCN(CC)CC,,val
US20040132710A1,COc1ccccc1[Mg]Br.O=C1CN(C(c2ccccc2)c2ccccc2)C1>>COc1ccccc1C1(O)CN(C(c2ccccc2)c2ccccc2)C1,,C1CCOC1,,,,val
US20110294858A1,COC(=O)c1ccc(CBr)nc1.Oc1ccccc1>>COC(=O)c1ccc(COc2ccccc2)nc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040106667A1,CC(C)(C)OC(=O)n1nc(I)c2cc(NS(=O)(=O)c3ccccc3S(C)(=O)=O)ccc21.OB(O)c1ccc2ccccc2c1>>CS(=O)(=O)c1ccccc1S(=O)(=O)Nc1ccc2[nH]nc(-c3ccc4ccccc4c3)c2c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20070270587A1,O=S(=O)(c1ccc2c(c1)C1(OCCCO1)C1=NCCCN12)N1CCC[C@H]1COc1ccccc1>>O=C1C2=NCCCN2c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21,,C1COCCO1,,Cl,[NH4+].[OH-],val
US20080132600A1,CN=C(Cl)c1ccccc1.O=C1c2ccccc2C(=O)N1O>>CN=C(ON1C(=O)c2ccccc2C1=O)c1ccccc1,,CN(C)C=O,,O,[Na],val
US20150266870A1,Nc1ncc(CCO)s1.O=S(Cl)Cl>>Nc1ncc(CCCl)s1,,ClC(Cl)Cl,,,,val
US20070208007A1,CCCN(CCC)Cc1cccc(C(=O)Nc2cc(C(=O)OC)ccc2N)c1.CI>>CCCN(CCC)Cc1cccc(C(=O)N(C)c2cc(C(=O)OC)ccc2N)c1,,CN(C)C=O,,[H-].[Na+],,val
US20070197558A1,Nc1cc([N+](=O)[O-])ccc1Cl.Oc1ccc(S)cc1>>Nc1cc([N+](=O)[O-])ccc1Sc1ccc(O)cc1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US05206229,C1=COCCC1.Cc1ccc(S(=O)(=O)OCCC2(O)CC2)cc1>>Cc1ccc(S(=O)(=O)OCCC2(OC3CCCCO3)CC2)cc1,,CCOCC,ClCCl,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US04163859,CC(=O)c1ccccc1.CCOC(=O)C(C)(C)Oc1ccc(C=O)cc1>>CCOC(=O)C(C)(C)Oc1ccc(C=CC(=O)c2ccccc2)cc1,,CCO,,,,val
US20150005279A1,C=CC(=O)Cl.NC(=O)c1cc2c(c3cc[nH]c13)NCC2>>C=CC(=O)N1CCc2cc(C(N)=O)c3[nH]ccc3c21,,ClCCl,,CCN(CC)CC,,val
US05849921,Cc1cccc(Br)c1.Cc1ncoc1C=O>>Cc1cccc(C(O)c2ocnc2C)c1,,C1CCOC1,,[Li]CCCC,O=C([O-])O.[Na+],val
US05541324,[N-]=[N+]=NCc1nc2ccccc2o1>>NCc1nc2ccccc2o1,[Pd],CCO,,,,val
US20100099718A1,CN1CCCC1=O.N#Cc1ccc(N)nc1N.[N-]=[N+]=[N-]>>N.Nc1ccc(-c2nn[nH]n2)c(N)n1,,CN1CCCC1=O,,CCN(CC)CC,Cl,val
US20160194350A1,CCC(OC(C)=O)[C@@H]1C[C@@H](O)[C@H](n2c(=O)sc3c(=O)[nH]c(N)nc32)O1>>CCC(OC(C)=O)[C@@H]1CC(=O)[C@H](n2c(=O)sc3c(=O)[nH]c(N)nc32)O1,,C1CCOC1,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090093473A1,O=C(O)c1cc(O)cc(O)c1>>O=C1C=C(O)CC(C(=O)O)C1,[Ni],[Na+],[OH-],[H][H],,val
US20020165264A1,CCOc1c(OCC)c(=O)c1=O.COc1ncccc1N>>CCOc1c(Nc2cccnc2OC)c(=O)c1=O,,CCO,,,,val
US20100036111A1,Cc1ccccc1C(=O)OC[C@H]1O[C@@H](n2cnc3c(-c4cccs4)ccnc32)C[C@@H]1OC(=O)c1ccccc1C>>OC[C@H]1O[C@@H](n2cnc3c(-c4cccs4)ccnc32)C[C@@H]1O,,N,,,,val
US05922724,CN(C)C=CC(=O)c1ccc2c(c1)ncn2-c1cccc(-c2ccncn2)c1>>c1cc(-c2ccncn2)cc(-n2cnc3cc(-c4ccno4)ccc32)c1,,CO,,O,,val
US20100010034A1,CC(=O)CBr.CCOC(=O)CCc1ccc(F)cn1>>CCOC(=O)Cc1c(C)cn2cc(F)ccc12,,CC#N,,c1ccncc1,,val
US20150175604A1,BrCc1ccccc1.Clc1ccc2[nH]ccc2n1>>Clc1ccc2c(ccn2Cc2ccccc2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150291595A1,CC1(C)OB(c2cc(NS(C)(=O)=O)cc3[nH]ccc23)OC1(C)C.Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(Br)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12>>Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cc(NS(C)(=O)=O)cc5[nH]ccc35)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12,,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090170921A1,COCCn1c(-c2ccc(C(C)C)cc2)nc2cc(C=O)cc(OC)c21.C[Mg]I>>COCCn1c(-c2ccc(C(C)C)cc2)nc2cc(C(C)O)cc(OC)c21,,C1CCOC1,,,,val
US20070167443A1,Brc1cnc(I)nc1.CON(C)C(=O)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O>>O=C(c1ncc(Br)cn1)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O,,C1CCOC1,,CC(C)[Mg]Cl,,val
US04128723,CC(C)(N)C#N.O=C(Cl)Sc1ccccc1>>CC(C)(C#N)NC(=O)Sc1ccccc1,,C1COCCO1,,,,val
US20100210704A1,CC(=O)Nc1cc(OCC(F)(F)C(F)(F)F)nn1-c1cc(SCC(F)(F)F)c(C)cc1F.O=C(OO)c1cccc(Cl)c1>>CC(=O)Nc1cc(OCC(F)(F)C(F)(F)F)nn1-c1cc(S(=O)CC(F)(F)F)c(C)cc1F,,ClC(Cl)Cl,,,,val
US20130216498A1,CI.N#C[C@@H]1C[C@H](F)CN1C(=O)n1ccnc1>>C[n+]1ccn(C(=O)N2C[C@@H](F)C[C@H]2C#N)c1.[I-],,CC#N,,,,val
US20130079333A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C1COCc2cc(Cl)ccc2N1>>S=C1COCc2cc(Cl)ccc2N1,,C1CCOC1,,,,val
US20030130340A1,CCCCCI.Oc1ccc2c(-c3cccnc3)csc2c1>>CCCCCOc1ccc2c(-c3cccnc3)csc2c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20030166644A1,CC(C)(C)[Si](C)(C)OC1CCN(C(=O)Oc2ccc(NC(=O)c3ccccc3)cn2)CC1.CC1(C)CC(=O)N(c2ccc(O)nc2)C(=O)C1>>CC1(C)CC(=O)N(c2ccc(OC(=O)N3CCC(O)CC3)nc2)C(=O)C1,,CN(C)C=O,Cl,CCN(CC)CC,CCOC(C)=O,val
US04570002,CC(C)C(=O)c1ccccc1.COC(=O)NN>>COC(=O)NN=C(c1ccccc1)C(C)C,,CO,,CC(=O)O,,val
US20060287315A1,Nc1ccc(Cl)cn1.O=C1OC(=O)c2nccnc21>>O=C(O)c1nccnc1C(=O)Nc1ccc(Cl)cn1,,C1CCOC1,,,,val
US20020052376A1,COC(=O)c1ncccc1C=Cc1ccc(F)cc1>>COC(=O)c1ncccc1CCc1ccc(F)cc1,[Pd],CCOC(C)=O,,,,val
US05719182,CCOC(=O)C1=C(c2ccc3c(c2)OCO3)c2ccccc2C1c1ccccc1OC>>CCOC(=O)C1C(c2ccc3c(c2)OCO3)c2ccccc2C1c1ccccc1OC,[Pd],CCO,,,,val
US20110130400A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)(C)C>>CC(C)(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1C[C@@H]2C[C@H]1CN2,,ClCCl,O=C(O)C(F)(F)F,[Na+].[OH-],,val
US20090197863A1,COC(=O)c1cccc2nc(-c3ccc(C)cc3)oc12.O=C1CCC(=O)N1Br>>COC(=O)c1cccc2nc(-c3ccc(CBr)cc3)oc12,,ClC(Cl)(Cl)Cl,,,,val
US20030199510A1,COc1ccc2c(c1)C(=O)CC2.O=C1Cc2ccccc2N1>>COc1ccc2c(c1)C(=C1C(=O)Nc3ccccc31)CC2,,CN(C)C=O,,C1CCNCC1,Cl,val
US20150166535A1,CC#C[C@@H](CC(=O)OCC)c1ccc(OCc2ccc3nc(Br)nn3c2)cc1.OB(O)c1ccc(O)cc1>>CC#C[C@@H](CC(=O)OCC)c1ccc(OCc2ccc3nc(-c4ccc(O)cc4)nn3c2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20160060233A1,Cc1ccc(C(C)C)c(N2CC(C)CSC2=N)c1.O=C=NC1Cc2ccc(-c3ncn(-c4ccc(OC(F)(F)F)cc4)n3)cc2C1>>Cc1ccc(C(C)C)c(N2CC(C)CS/C2=N\C(=O)NC2Cc3ccc(-c4ncn(-c5ccc(OC(F)(F)F)cc5)n4)cc3C2)c1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080015202A1,COC(=O)CCc1ccc(CCc2csc(NC(C)=O)n2)s1>>CC(=O)Nc1nc(CCc2ccc(CCC(=O)O)s2)cs1,,C1COCCO1,,[Na+].[OH-],,val
US04960909,CC1(C)[C@H]2C[C@H](O)[C@@H](CCOC3CCCCO3)[C@@H]1C2>>CC1(C)C2CCCC1C2,,CCOCC,ClCCl,CCN(CC)CC,CS(=O)(=O)Cl,val
US05084085,Cc1nn(-c2cc(O)c(Cl)cc2Cl)c(=O)n1C(F)F.O=[N+]([O-])c1ccc(Cl)cc1>>Cc1nn(-c2cc(Oc3ccc([N+](=O)[O-])cc3)c(Cl)cc2Cl)c(=O)n1C(F)F,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20110237797A1,CCN.O=C(O)Cc1cc2c3c(c1)C(c1ccccc1)CCN3CCC2c1ccccc1>>CCNC(=O)Cc1cc2c3c(c1)C(c1ccccc1)CCN3CCC2c1ccccc1,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20100022590A1,CC(C)(O)[C@H]1CCCNC1.O=C(O)c1conc1-c1ccccc1Cl>>CC(C)(O)[C@H]1CCCN(C(=O)c2conc2-c2ccccc2Cl)C1,,ClCCl,O=S(Cl)Cl,CCN(CC)CC,Cl,val
US04775692,C=[N+]=[N-].O=C(O)CCC1CCCCC1>>COC(=O)CCC1CCCCC1,,CCOCC,,,,val
US04699915,CN(C)/C=C/C(=O)c1ccc([N+](=O)[O-])cc1.NN>>O=[N+]([O-])c1ccc(-c2cc[nH]n2)cc1,,CCO,,O,,val
US20080249151A1,CO[Na].Fc1cc(Br)cc(Br)c1>>COc1cc(Br)cc(Br)c1,,CN(C)C=O,,,,val
US20130252937A1,CC(C)(O)C(=O)O.Cc1cc(C(=N)NO)cc(C)c1Br>>Cc1cc(-c2noc(C(C)(C)O)n2)cc(C)c1Br,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20110257151A1,COC(=O)c1ccc2c(c1)CC(C)(C)C(c1ccc(Cl)c([N+](=O)[O-])c1)N2>>COC(=O)c1ccc2c(c1)CC(C)(C)C(c1ccc(Cl)c(N)c1)N2,[Fe],CCO,O,Cl,,val
US05552427,CCOC(=O)Cl.Cn1ccnc1N>>CCOC(=O)Nc1nccn1C,,c1ccncc1,,Cl,,val
US20020193382A1,COC(=O)CS(=O)(=O)Cl.O=C1CNCCN1Cc1ccc(-n2ccnc2)cc1>>COC(=O)CS(=O)(=O)N1CCN(Cc2ccc(-n3ccnc3)cc2)C(=O)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080039459A1,CN(C)C=O.Clc1nc(N2CCOCC2)c2occc2n1>>O=Cc1cc2nc(Cl)nc(N3CCOCC3)c2o1,,C1CCOC1,,[Li]CCCC,,val
US20090312328A1,COc1ccc(CNC(=O)CBr)cc1.Cc1c(N)cccc1Cl>>COc1ccc(CNC(=O)CNc2cccc(Cl)c2C)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06063803,C=CC(=O)Cl.Nc1cc(F)ccc1C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-]>>C=CC(=O)Nc1cc(F)ccc1C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-],,ClCCl,,c1ccncc1,,val
US20010036945A1,CCCNCC1CC1.Cc1cc(C)c(C2(Cl)NN=Cc3ccccc32)c(C)c1>>CCCN(CC1CC1)c1nnc(-c2c(C)cc(C)cc2C)c2ccccc12,,Cc1ccccc1,,,,val
US06172045B2,COC(=O)CCCCCN(C)C(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21>>CN(CCCCCC(=O)O)C(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21,,CO,,[Na+].[OH-],,val
US04328247,CC(C)c1cc(Br)cc(C(C)C)c1N.Oc1ccccc1>>CC(C)c1cc(Oc2ccccc2)cc(C(C)C)c1N,Cl[Cu]Cl,Cc1ccccc1C,,[K+].[OH-],,val
US20080255118A1,CSc1nc(Cc2cccc(C)c2)[nH]c(=O)c1C#N.NC1CCCC1>>Cc1cccc(Cc2nc(NC3CCCC3)c(C#N)c(=O)[nH]2)c1,,CC#N,,,,val
US20040058919A1,CC#CN1CC[C@@H](CCC(=O)c2ccnc3ccc(OC)cc23)[C@@H](C(=O)OC)C1.Fc1cc(F)c(F)c(Br)c1>>COC(=O)[C@H]1CN(CC#Cc2cc(F)cc(F)c2F)CC[C@H]1CCC(=O)c1ccnc2ccc(OC)cc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCN(CC)CC,O,,,val
US20080234260A1,CNC.S=C(n1ccnc1)n1ccnc1>>CN(C)C(=S)n1ccnc1,,C1CCOC1,,,,val
US20090036678A1,CC(C)[Si](OC[C@@H]1C[C@@H](NC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@@H]1O)(C(C)C)C(C)C>>OC[C@@H]1C[C@@H](NC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@@H]1O,,CCCCCCC,CCOC(C)=O,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20050288273A1,CC(=O)NC[C@H]1CN(c2cc(F)c3c(c2)CCCCC3=O)C(=O)O1>>CC(=O)NC[C@H]1CN(c2cc(F)c3c(c2)CCCCC3O)C(=O)O1,,CO,,[BH4-].[Na+],,val
US03987091,CCCCCC(CCCCl)OC1CCCCO1.O=C1NC(=O)c2ccccc21>>CCCCCC(CCCN1C(=O)c2ccccc2C1=O)OC1CCCCO1,,CN(C)C=O,,,,val
US20100004271A1,COc1ccc2nn(C)cc2c1.O=C1CCC(=O)N1Br>>COc1ccc2nn(C)c(Br)c2c1,,CC(=O)O,,,,val
US20090075979A1,CCOC(=O)C[C@@H]1CC[C@@H](CN(CC)c2cccnc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC1.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)C[C@@H]1CC[C@@H](CN(CC)c2ccc[n+]([O-])c2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC1,,ClCCl,,,,val
US20080021026A1,CO.Cc1c(-c2ccnc(N)n2)sc2ccc(C#N)cc12.[Li]c1ccccc1>>Cc1c(-c2ccnc(N)n2)sc2ccc(C(=O)c3ccccc3)cc12,,CO,,C1CCOC1,,val
US20030109538A1,CS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)nc(S(C)(=O)=O)n2)cc1.NCc1cccnc1>>CS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)nc(NCc3cccnc3)n2)cc1,,CC#N,,,,val
US20120010228A1,CC(C)(C)OC(=O)N1CCC2(CC1)C(=O)N(CCCCCC(=O)OCc1ccccc1)CN2c1ccccc1>>O=C(CCCCCN1CN(c2ccccc2)C2(CCNCC2)C1=O)OCc1ccccc1,,C1COCCO1,,Cl,,val
US20060116406A1,CC(=O)c1ccc(F)cc1O.CCOC(=O)OCC>>O=c1cc(O)c2ccc(F)cc2o1,,CCOC(C)=O,Cc1ccccc1,Cl,[H-].[Na+],val
US20120053173A1,COC(=O)c1ccc(NC(c2oc3cccnc3c2C)C2CCCCC2)cc1>>Cc1c(C(Nc2ccc(C(=O)O)cc2)C2CCCCC2)oc2cccnc12,,CCO,,C1CCOC1,[Na+].[OH-],val
US20100216746A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1nc(C=O)c[nH]1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1nc(Br)c(C=O)[nH]1,,CCOC(C)=O,CN(C)C=O,,,val
US20050176789A1,CCC(C(=O)O)c1ccccc1.Nc1nc2c(s1)C(=O)CCC2>>CCC(C(=O)Nc1nc2c(s1)C(=O)CCC2)c1ccccc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160207905A1,O=C1C=CCC1.O=[N+]([O-])c1cn[nH]c1>>O=C1CCC(n2cc([N+](=O)[O-])cn2)C1,,ClC(Cl)Cl,,O,,val
US05616610,COc1ccc(F)c2c1C[C@@H](N(Cc1ccccc1)Cc1ccccc1)CO2>>COc1ccc(F)c2c1C[C@@H](N)CO2,[Pd],C1CCOC1,CO,O=C[O-].[NH4+],,val
US20150133446A1,O=C(Cl)C(=O)Cl.O=C(O)c1cn2nc(Br)sc2n1>>O=C(Cl)c1cn2nc(Br)sc2n1,CN(C)C=O,ClCCl,,,,val
US20040077622A1,CCOC(=O)c1cc2n(n1)CCO2>>OCc1cc2n(n1)CCO2,,C1CCOC1,,CO,[BH4-].[Li+],val
US20140336198A1,CON(C)C(=O)C1CN(C(=O)OC(C)(C)C)C1.Fc1ccc(Br)cc1>>CC(C)(C)OC(=O)N1CC(C(=O)c2ccc(F)cc2)C1,,C1CCOC1,,[Li]CCCC,,val
US20090042874A1,CC(C)(C)OC(=O)N1CC[C@H](O)C1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CC[C@H](OS(=O)(=O)c2ccccc2[N+](=O)[O-])C1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20130240784A1,CCCC1CC=C(c2ccc(Br)cc2F)CC1>>CCCC1CCC(c2ccc(Br)cc2F)CC1,[Pd],CC(C)O,,Cc1ccccc1,,val
US20150133400A1,CCOC(=O)c1ccc(-n2cc(CC3CCC(F)(F)CC3)c3cc(-c4c(C)noc4C)cnc32)nc1>>Cc1noc(C)c1-c1cnc2c(c1)c(CC1CCC(F)(F)CC1)cn2-c1ccc(C(=O)O)cn1,,C1CCOC1,,O,[Li+].[OH-],val
US20120046267A1,CC(C)(C)S.O=Cc1cc([N+](=O)[O-])cc(Br)c1F>>CC(C)(C)Sc1c(Br)cc([N+](=O)[O-])cc1C=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20030065031A1,COC(=O)CCNC(=O)c1ccc(C=O)cc1.Nc1ccc(C2CCCCC2)cc1>>COC(=O)CCNC(=O)c1ccc(CNc2ccc(C3CCCCC3)cc2)cc1,,CO,,[BH3-]C#N.[Na+],,val
US20120129856A1,CC(C)(CCCCC(c1ccccc1Cl)N1CCc2[nH]ccc2C1)C(=O)O.Cl>>CC(C)(CCCCC(c1ccccc1Cl)N1CCc2[nH]ccc2C1)C(=O)O.Cl,,CCOCC,,,,val
US20050101587A9,CCOC(=O)C=Cc1cc(Cl)ccc1NC1CCN(C(=O)OC(C)(C)C)CC1>>CCOC(=O)CCc1cc(Cl)ccc1NC1CCN(C(=O)OC(C)(C)C)CC1,O=[Pt]=O,CCOC(C)=O,,,,val
US20120149681A1,CI.OCc1cc(Cl)nc(C(F)(F)F)c1>>COCc1cc(Cl)nc(C(F)(F)F)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070259888A1,C=CCOCC1CCCNC1.CC(C)(C)OC(=O)N[C@@H]1CCCC[C@H]1C=O>>C=CCOCC1CCCN(C[C@@H]2CCCC[C@H]2NC(=O)OC(C)(C)C)C1,,ClCCl,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100317515A1,CSSC.Fc1ccc([C@@]2(Cn3cncn3)O[C@@H]2c2ccccc2C(F)(F)F)cc1F>>CSc1ncnn1C[C@]1(c2ccc(F)c(F)c2)O[C@@H]1c1ccccc1C(F)(F)F,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US06180378B2,CCCCC/C=C\C/C=C\CCCCCCCC(=O)O.[O-]O>>CCCCC/C=C\C/C=C\CCCCCCCC(=O)OO,,ClCCl,,,,val
US20080132563A1,CON(C)C(=O)c1cc(Br)ccc1Cl>>O=Cc1cc(Br)ccc1Cl,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20070060607A1,Clc1cccc(CBr)c1.Oc1cccc(O)c1>>Oc1cccc(OCc2cccc(Cl)c2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160168139A1,ICCOCCI.N[C@H]1COC[C@H]1Nc1ccc2c(c1)Sc1cccc(-c3cc(N4CCOCC4)cc(=O)[nH]3)c1S2>>O=c1cc(N2CCOCC2)cc(-c2cccc3c2Sc2ccc(N[C@@H]4COC[C@@H]4N4CCOCC4)cc2S3)[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20080306082A1,CN1CCN(CCCNc2nccc(-c3cc4ccc(CNC(=O)OC(C)(C)C)cc4s3)n2)CC1>>CN1CCN(CCCNc2nccc(-c3cc4ccc(CN)cc4s3)n2)CC1,,ClCCl,,CO,O=C(O)C(F)(F)F,val
US03950528,CCOC(=O)C=C(N)OCC.NNCc1ccc(Br)c(Cl)c1>>Nc1cc(=O)n(Cc2ccc(Br)c(Cl)c2)[nH]1,,CCO,,Cc1ccccc1S(=O)(=O)O,,val
US20050288273A1,CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCCC3=O)C(=O)O1.CCN(CC)CCOc1ccc(C=O)cc1>>CCN(CC)CCOc1ccc(C=C2CCCc3cc(N4C[C@H](CNC(C)=O)OC4=O)ccc3C2=O)cc1,,CC(=O)O,,C1CCNCC1,,val
US20160264547A1,COC(=O)[C@@H](C)O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)[C@@H](C)OS(=O)(=O)C(F)(F)F,,ClCCl,,Cc1cccc(C)n1,,val
US20110207704A1,CC(C)Oc1ccc(C#N)cc1Cl.Nc1ccc(C(=O)O)cc1.O=C(O)c1ccncc1>>CC(C)Oc1ccc(-c2noc(-c3ccc(N)cc3)n2)cc1Cl,CN(C)C=O,,,O=S(Cl)Cl,,val
US04880790,N#CCC#N.O=S(=O)(CCCl)CCCl>>N#CC1(C#N)CCSCC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040048908A1,CCOC(=O)CC(=O)OCC.Cc1ccc(-c2oncc2CCl)cc1>>Cc1ccc(-c2oncc2CCC(=O)O)cc1,,C1CCOC1,,Cl,[H-].[Na+],val
US20110105509A1,Cc1[nH]c2ccc(Cl)cc2c1CC(=O)c1ccccc1C(=O)O.NN>>Cc1[nH]c2ccc(Cl)cc2c1Cc1n[nH]c(=O)c2ccccc12,,CC(C)O,,,,val
US20150011546A1,CCc1ccc(F)cc1.O=C1CCC(=O)N1Br>>CC(Br)c1ccc(F)cc1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20080234335A1,CCOC(=O)c1cc(Cl)ccn1.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)c1cc(Cl)cc[n+]1[O-],,ClCCl,,,,val
US20100285145A1,CC(C)OC(=O)N1CCC(Oc2cc(N3CCc4cc(S(=O)(=O)CCO[Si](C)(C)C(C)(C)C)ccc43)ncn2)CC1>>CC(C)OC(=O)N1CCC(Oc2cc(N3CCc4cc(S(=O)(=O)CCO)ccc43)ncn2)CC1,,C1COCCO1,,Cl,,val
US20150307488A1,Cc1nc([C@H]2C[C@@H]2c2cn3ccccc3n2)cc(-n2nc(C)nc2C)n1.II>>Cc1nc([C@@H]2C[C@H]2c2nc3ccccn3c2I)cc(-n2nc(C)nc2C)n1,,ClCCl,,,,val
US20090298924A1,CC(C)(C)OC(=O)N[C@@H](CCO)C(=O)OC1CCCC1.O=[N+]([O-])c1ccccc1O>>CC(C)(C)OC(=O)N[C@@H](CCOc1ccc([N+](=O)[O-])cc1)C(=O)OC1CCCC1,,ClCCl,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080064729A1,CC(C#N)c1cccc(C(=O)O)c1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(CNC(=O)OC(C)(C)C)c1cccc(C(=O)O)c1,,C1CCOC1,,,,val
US20050256191A1,CC1(C)OCC(CNC(=O)c2cc([N+](=O)[O-])cc([N+](=O)[O-])c2N(CCOS(C)(=O)=O)CCOS(C)(=O)=O)O1>>CS(=O)(=O)OCCN(CCOS(C)(=O)=O)c1c(C(=O)NCC(O)CO)cc([N+](=O)[O-])cc1[N+](=O)[O-],,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05972965,O=C(c1cccc(OCc2ccccc2)c1)N1CCCCC1c1nc(-c2ccccc2)c(-c2ccccc2)o1>>O=C(c1cccc(O)c1)N1CCCCC1c1nc(-c2ccccc2)c(-c2ccccc2)o1,[Pd],CCOC(C)=O,,,,val
US05721234,CC(=O)Nc1c(Br)cc2c(c1[N+](=O)[O-])CC(NC(C)=O)C2>>CC(=O)NC1Cc2cc(Br)c(N)c([N+](=O)[O-])c2C1,,O,,O=S(=O)(O)O,,val
US04997943,CCOC(=O)CC(=O)c1cc(F)c(F)c(OC)c1F.CCOC([O-])[O-].NC1CC1>>CCOC(=O)C(=CNC1CC1)C(=O)c1cc(F)c(F)c(OC)c1F,,ClCCl,,CC(=O)OC(C)=O,,val
US20030018034A1,Cc1ccc(C(C)(C)C#N)cc1.OCCOCCO.[OH-]>>Cc1ccc(C(C)(C)C(=O)O)cc1,,O,,Cl,,val
US20040058965A1,COC(=O)Cc1cccc(O)c1.COc1ccc(CCl)cc1OCc1nc(-c2ccccc2)oc1C>>COC(=O)Cc1cccc(OCc2ccc(OC)c(OCc3nc(-c4ccccc4)oc3C)c2)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090192169A1,Cc1cccc2nc(CC3CCN(C(=O)OC(C)(C)C)CC3)n(C)c12>>Cc1cccc2nc(CC3CCNCC3)n(C)c12,,ClC(Cl)Cl,ClCCl,O=C(O)C(F)(F)F,,val
US20070149542A1,CS(=O)(=O)c1cccc(C2CCNCC2)c1F.FC(F)(F)CCI>>CS(=O)(=O)c1cccc(C2CCN(CCC(F)(F)F)CC2)c1F,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20030199571A1,CC(C)(C)[Si](C)(C)ON.O=C(O)[C@H](NS(=O)(=O)Cc1ccc2sccc2c1)c1ccccc1>>O=C(NO)[C@H](NS(=O)(=O)Cc1ccc2sccc2c1)c1ccccc1,,ClCCl,,CCOC(C)=O,O=C([O-])O.[Na+],val
US06080870,Cc1ccc(-c2ccccc2C(F)(F)F)cc1C#N.O=C1CCC(=O)N1Br>>N#Cc1cc(-c2ccccc2C(F)(F)F)ccc1CBr,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20060234997A1,COc1ccc(CCN)c(N)c1.O=C(n1ccnc1)n1ccnc1>>COc1ccc2c(c1)NC(=O)NCC2,,C1CCOC1,CCOC(C)=O,Cl,,val
US06987119B2,O=C(Cl)C(=O)Cl.O=C(O)c1nc(-c2ccncc2)c(-c2ccc(Cl)c(O)c2)[nH]1>>O=C(Cl)c1nc(-c2ccncc2)c(-c2ccc(Cl)c(O)c2)[nH]1,CN(C)C=O,ClCCl,,,,val
US05250527,C1COCCN1.OCc1nccc(Cl)c1Cl>>OCc1nccc(N2CCOCC2)c1Cl,,CCO,,,,val
US20050070441A1,COC(=O)C#CC(=O)OC.NN>>COC(=O)c1cc(O)n[nH]1,,Cc1ccccc1,,O,,val
US05223498,COCCN(CCOC)c1ccccc1N=C=S.N>>COCCN(CCOC)c1ccccc1NC(N)=S,,CCO,,,,val
US20080021081A1,CCOC(=O)/C=C/c1ccc(Br)cc1>>OCC=Cc1ccc(Br)cc1,,ClCCl,,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US06413972B1,Cc1c(Cc2ccccc2)c(=O)n2c(CN(C)Cc3ccccc3)c(-c3ccc(NC(=O)OC(C)(C)C)cc3)nc2n1Cc1c(F)cccc1F>>Cc1c(Cc2ccccc2)c(=O)n2c(CN(C)Cc3ccccc3)c(-c3ccc(N)cc3)nc2n1Cc1c(F)cccc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050209338A1,CC(=O)O.N.O=C1CNC(=O)N1c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1>>NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1.O=CO,,CO,,,,val
US20120329848A1,CC(C)[Si](Cl)(C(C)C)C(C)C.Cc1cc(O)ccc1N>>Cc1cc(O[Si](C(C)C)(C(C)C)C(C)C)ccc1N,,C1CCOC1,COC(C)(C)C,c1c[nH]cn1,,val
US20080076924A1,COCCOCCl.OCC1CN(Cc2ccccc2)CCN1Cc1ccccc1>>COCCOCOCC1CN(Cc2ccccc2)CCN1Cc1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US04152432,CCON=C(C(=O)OCC)c1csc(N)n1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCON=C(C(=O)OCC)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,CCN(CC)CC,ClCCl,CN(C)C=O,Cl,val
US20080312226A1,CCc1sc(N2CCNCC2)nc1-c1ccccc1.O=C(Nc1cccnc1)OCC(Cl)(Cl)Cl>>CCc1sc(N2CCN(C(=O)Nc3cccnc3)CC2)nc1-c1ccccc1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US04140785,CC(=O)OC(C)=O.Cc1ccc2c(c1)sc1c(N)nn(C)c12>>CC(=O)Nc1nn(C)c2c1sc1cc(C)ccc12,,C1CCOC1,,,,val
US20100003191A1,CC(=O)O.O=C(O)COc1ccc(Br)cc1C(=O)O>>CC(=O)Oc1coc2ccc(Br)cc12,,CC(=O)O,CC(=O)OC(C)=O,CC(=O)[O-].[Na+],,val
US20010012857A1,CC(C)(C)c1ccc(O)cc1.CCOC(=O)CN(C)CC[C@H](O)c1ccccc1>>CCOC(=O)CN(C)CC[C@@H](Oc1ccc(C(C)(C)C)cc1)c1ccccc1,,ClC(Cl)Cl,,,,val
US20140031563A1,CCOC(=O)C(=O)OCC.O=C(Cc1ccccc1)Nc1ccccc1Cl>>O=C1C(O)=C(c2ccccc2)C(=O)N1c1ccccc1Cl,,O,,CC(C)(C)[O-].[K+],,val
US05925630,CC(C)C(=O)Cl.CO[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C>>CO[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](OC(=O)C(C)C)CC[C@]4(C)[C@H]3CC[C@]12C,,ClCCl,c1ccncc1,,,val
US05055223,CCCCCOc1ccc(C#Cc2ccc(S(F)(F)(F)(F)F)cc2)cc1>>CCCCC[C@@H]1CC[C@@H](CCc2ccc(S(F)(F)(F)(F)F)cc2)CC1,[Pd],,,Cc1ccccc1,,val
US20100286206A1,O=c1c(C(F)(F)F)c(OCc2ccccc2)ccn1CC1CC1>>O=c1c(C(F)(F)F)c(O)ccn1CC1CC1,[Pd],CCO,,,,val
US05486611,C[Si](C)(C)N=C=O.Cc1ccccc1N1CCC[C@H]2c3c(Br)cccc3CC[C@@H]21>>Cc1ccccc1N1CCC[C@H]2c3c(cccc3C(N)=O)CC[C@@H]21,,C1CCOC1,CCCCC,,,val
US20070142434A1,COc1ccc(B(O)O)cc1.c1ccc2[nH]ncc2c1>>COc1ccc(-n2ncc3ccccc32)cc1,,ClCCl,O,CCN(CC)CC,,val
US20040097546A1,COC(=O)/C=C/c1ccc(F)cc1.COCN(C[Si](C)(C)C)C(C)(C)C>>COC(=O)[C@@H]1CN(C(C)(C)C)C[C@H]1c1ccc(F)cc1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20110021780A1,CCOC(=O)Cl.Nc1cccnc1>>CCOC(=O)NC1CCCNC1,,O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20080153836A1,CCC(=O)c1cc(C(=O)OC)c(C)cc1C(F)(F)F.CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)NN>>CCC(=O)c1cc2c(=O)n(NS(C)(=O)=O)c(=O)[nH]c2cc1C(F)(F)F,,C1CCOC1,CCOC(C)=O,Cl,[Na+].[OH-],val
US20150368249A1,FC(F)(F)CI.O=C1c2ccccc2C(=O)N1c1cc(O)n[nH]1>>O=C1c2ccccc2C(=O)N1c1cc(OCC(F)(F)F)n[nH]1,,CN(C)C=O,O,[H-].[Na+],,val
US20140243336A1,C[Mg]Cl.O=C1CCCc2nc(Cl)ccc21>>CC1(O)CCCc2nc(Cl)ccc21,,C1CCOC1,,,,val
US20140187529A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Nc1ccc(-c2nc(Br)cnc2N)cc1>>CC1(C)OB(c2cnc(N)c(-c3ccc(N)cc3)n2)OC1(C)C,,C1COCCO1,,ClCCl,CC(=O)[O-].[K+],val
US20060004018A1,C1CNCCN1.Cc1cc(C(F)(F)F)cc(Cl)n1>>Cc1cc(C(F)(F)F)cc(N2CCNCC2)n1,,C1COCCO1,O,CCN(CC)CC,,val
US20060217372A1,C1CCNCC1.O=Cc1ccc(Oc2ccc(C(=O)O)cn2)cc1>>O=Cc1ccc(Oc2ccc(C(=O)N3CCCCC3)cn2)cc1,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US20050119305A1,CC(=O)SCCCCC(O)c1ccc(-c2ccc(Cl)cc2)cc1>>OC(CCCCS)c1ccc(-c2ccc(Cl)cc2)cc1,,CO,,Cl,[Na+].[OH-],val
US20060094843A1,CCCCC1(C(=O)OCC)CCCC1O.O=C(Cl)c1ccccc1>>CCCCC1(C(=O)OCC)CCCC1OC(=O)c1ccccc1,,ClCCl,,c1ccncc1,,val
US20070219229A1,CCOC(=O)Cc1c(C(=O)OCC)ccn1Cc1ccc(OC)cc1.CCOC=O>>CCOC(=O)C(=CO)c1c(C(=O)OCC)ccn1Cc1ccc(OC)cc1,,C1CCOC1,,[H-].[Na+],,val
US20160046614A1,BrC(Br)(Br)Br.CC(C)(C)OC(=O)NCCCCCCO>>CC(C)(C)OC(=O)NCCCCCCBr,,Cc1ccccc1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20110311474A1,CCOC(OCC)OCC.Cc1ccc(S(=O)(=O)n2ccc3nc(NN)cnc32)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c2ncc2nncn23)cc1,,CN(C)C=O,,,,val
US20130022587A1,CCOC(=O)C(CCCNC(=O)OC(C)(C)C)Cc1cn(C2CCCC(C)(C)C2)cn1>>CC1(C)CCCC(n2cnc(CC(CCCN)C(=O)O)c2)C1,,Cl,,,,val
US20160046635A1,C1CC2(CCN1)OCCO2.CCCNc1nc(NC)c2nc(Cl)nc(NC)c2n1>>CCCNc1nc(NC)c2nc(N3CCC4(CC3)OCCO4)nc(NC)c2n1,,CCCCO,,O=C([O-])O.[Na+],,val
US20160090374A1,CC(C)(C)OC(=O)N[C@H]1CCN(c2nc(Cl)nc3cccnc23)C1.CCCBr>>CCCN(C(=O)OC(C)(C)C)[C@H]1CCN(c2nc(Cl)nc3cccnc23)C1,,O,,CN(C)C=O,[H-].[Na+],val
US20070082912A1,CC(=O)CCC(=O)c1cc(Cl)ccc1OCc1ccc(Br)cc1F.COC(=O)c1cc(N)ccc1NC(C)=O>>COC(=O)c1cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(Br)cc2F)ccc1NC(C)=O,,CC#N,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120214803A1,Nc1ccc(C(F)(F)F)c2cccnc12.O=S(=O)(Cl)c1ccc(C(F)(F)F)nc1>>O=S(=O)(Nc1ccc(C(F)(F)F)c2cccnc12)c1ccc(C(F)(F)F)nc1,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20140364432A1,Cc1nc(C(=O)N2CCC[C@@H](C)[C@H]2CN2C(=O)c3ccccc3C2=O)c(-c2ccc(F)cc2)s1>>Cc1nc(C(=O)N2CCC[C@@H](C)[C@H]2CN)c(-c2ccc(F)cc2)s1,,CO,,NN,O,val
US20090105218A1,Nc1ccccc1C(=O)O.O=C(Cl)c1cccc([N+](=O)[O-])c1>>O=C(Nc1ccccc1C(=O)O)c1cccc([N+](=O)[O-])c1,,ClCCl,,CCN(CC)CC,Cl,val
US20130053341A1,NC(=O)c1ccccc1N.O=C(O)c1ccnnc1>>NC(=O)c1ccccc1NC(=O)c1ccnnc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060084663A1,CCOC(=O)COc1ccc(OCc2sc(-c3ccc(C(F)(F)F)cc3)nc2CC)c(C)c1>>CCc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc(OCC(=O)O)cc1C,,C1CCOC1,,Cl,[Li+].[OH-],val
US20100121052A1,C[C@H](CO)NC(=O)OC(C)(C)C.Cn1cc(-c2cc(O)cc([N+](=O)[O-])c2)cn1>>C[C@H](COc1cc(-c2cnn(C)c2)cc([N+](=O)[O-])c1)NC(=O)OC(C)(C)C,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120077781A1,Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCN(Cc3ccc(Cl)cc3)C(=O)OC(C)(C)C)c2cc1OC1CCCC1>>Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCNCc3ccc(Cl)cc3)c2cc1OC1CCCC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20150252038A1,ClC[C@H]1CO1.Clc1ccc(Br)cc1Cl>>O[C@@H](CCl)Cc1ccc(Cl)c(Cl)c1,I[Cu]I,CCOCC,,[Mg],,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(Oc3nc(Cl)ns3)cc(C)c21>>Cc1cc(Oc2nc(Cl)ns2)cc2c1C(CC(=O)O)OB2O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20050070441A1,CCN=C=O.COC(=O)c1cc(Oc2c(Cl)cc(C(F)(F)F)cc2Cl)n[nH]1>>CCNC(=O)n1nc(Oc2c(Cl)cc(C(F)(F)F)cc2Cl)cc1C(=O)OC,,CCOC(C)=O,,CCN(CC)CC,Cl,val
US20150111877A1,C=CCN(c1cc(C(=O)OC)cnc1C=C)S(=O)(=O)c1cccc(C)c1>>COC(=O)c1cnc2c(c1)N(S(=O)(=O)c1cccc(C)c1)CC=C2,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,ClCCCl,,,,val
US20080027093A1,C[C@@H](C1CCC(NC(=O)c2ccc(OC(F)(F)F)cc2)CC1)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CC[C@H](F)C1.O=C(O)C(F)(F)F>>C[C@@H](C1CCC(NC(=O)c2ccc(OC(F)(F)F)cc2)CC1)[C@H]([NH3+])C(=O)N1CC[C@H](F)C1.O=C([O-])C(F)(F)F,,ClCCl,,,,val
US20040049042A1,C[C@]12CCC(=O)NC1=CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C(=O)O)CC[C@@H]12>>C[C@]12CCC(=O)N[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C(=O)O)CC[C@@H]12,,CC(=O)O,,C,O=C[O-].[NH4+],val
US20120329649A1,Cc1cc(/C=C/C(c2cc(Cl)cc(Cl)c2)C(F)(F)F)ccc1C(=O)NCC(=O)NNC(=O)C1CC1>>Cc1cc(/C=C/C(c2cc(Cl)cc(Cl)c2)C(F)(F)F)ccc1C(=O)NCc1nnc(C2CC2)o1,,O=P(Cl)(Cl)Cl,,,,val
US20150239884A1,COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2c(-c3cnn(C4CCN(C(=O)OC(C)(C)C)CC4)c3)cccc2cn1>>COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2c(-c3cnn(C4CCNCC4)c3)cccc2cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04277498,CC(CC1CCCCC1)NC(=O)CN1C(=O)c2ccccc2C1=O>>CC(N)CC1CCCCC1,,CCO,,NN,O,val
US04126635,CSC1(C)C(=O)Nc2c(C(=O)c3ccccc3)cccc21>>CC1C(=O)Nc2c(C(=O)c3ccccc3)cccc21,,C1CCOC1,,,,val
US20130079346A1,COC(=O)c1cc(C(N)=S)ccc1Br.O=C(CBr)c1ccc(Cl)c(Cl)c1>>COC(=O)c1cc(-c2nc(-c3ccc(Cl)c(Cl)c3)cs2)ccc1Br,,CCO,,,,val
US20160096842A1,CCC(CC)O[C@@H]1C=C(C(=O)OC[C@@H]2[C@H]3OC(C)(C)O[C@H]3[C@H](c3c[nH]c4c(N=[N+]=[N-])ncnc34)N2C(=O)OC(C)(C)C)C[C@H](NC(=O)OC(C)C)[C@H]1NC(C)=O.CP(C)C>>CCC(CC)O[C@@H]1C=C(C(=O)OC[C@@H]2[C@H]3OC(C)(C)O[C@H]3[C@H](c3c[nH]c4c(N)ncnc34)N2C(=O)OC(C)(C)C)C[C@H](NC(=O)OC(C)(C)C)[C@H]1NC(C)=O,,C1CCOC1,O,,,val
US20130190306A1,CNC.O=Cc1ccc(C2Nc3cccc4c(=O)[nH]nc(c34)C2c2ccc(C(=O)N3CCN(C(=O)C4CC4)CC3)cc2)cc1>>CN(C)Cc1ccc(C2Nc3cccc4c(=O)[nH]nc(c34)C2c2ccc(C(=O)N3CCN(C(=O)C4CC4)CC3)cc2)cc1,,CO,,[BH4-].[Na+],,val
US20160276592A1,BrCCCCCCCCBr.CC(=O)/C=C/c1ccc(O)cc1>>CC(=O)/C=C/c1ccc(OCCCCCCCCBr)cc1,,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],,val
US04855323,C=CCc1cccc(C2CCCC2)c1O.ClCc1ccccc1>>C=CCc1cccc(C2CCCC2)c1OCc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160214956A1,CCOC(=O)c1cnn(-c2cccc(-c3ccccc3CCc3ccc(O)cc3C)n2)c1C(F)(F)F.FC(F)(F)CCCBr>>CCOC(=O)c1cnn(-c2cccc(-c3ccccc3CCc3ccc(OCCCC(F)(F)F)cc3C)n2)c1C(F)(F)F,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100298336A1,Cc1ncsc1CBr.Oc1cc(C(F)(F)F)nc(S)n1>>Cc1ncsc1CSc1nc(O)cc(C(F)(F)F)n1,,CCO,,Br,CCN(CC)CC,val
US20110118354A1,COC(=O)C1=C(C)CC(C)CC1=O.Clc1ccc([Mg]Br)cc1Cl>>COC(=O)C1=C(C)CC(C)CC1(O)c1ccc(Cl)c(Cl)c1,,C1CCOC1,,[Cl-].[NH4+],,val
US20120178622A1,CN(C)C=O.NC(=O)c1ccc(Cl)cc1.O=C(O)c1c(I)cc(C(F)(F)F)c(F)c1F>>O=c1[nH]c(-c2ccc(Cl)cc2)nc2cc(C(F)(F)F)c(F)c(F)c12,[Cu]I,CCOC(C)=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20130175510A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1cccc(-c2cccc(-c3ccc4c5ccccc5c5ccccc5c4c3)c2)c1>>O=S(=O)(Oc1cccc(-c2cccc(-c3ccc4c5ccccc5c5ccccc5c4c3)c2)c1)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US20060229349A1,NC1CC1.O=C(O)Cc1cc([N+](=O)[O-])cc(F)c1F>>O=C1Cc2cc([N+](=O)[O-])cc(F)c2N1C1CC1,,CS(C)=O,,Cl,,val
US20020028832A1,COC(=O)c1ccc(C(=O)N2CCC(Nc3ccc(CCNC[C@H](O)c4ccc(O)c(NS(C)(=O)=O)c4)cc3)CC2)cc1>>CS(=O)(=O)Nc1cc([C@@H](O)CNCCc2ccc(NC3CCN(C(=O)c4ccc(C(=O)O)cc4)CC3)cc2)ccc1O,,CO,,[Na+].[OH-],,val
US20150225397A1,CO.COc1nc(Cl)nc2c1CC[C@H]1[C@H](C)C(=O)C(C#N)=C[C@]21c1ccccc1>>COc1nc(OC)c2c(n1)[C@@]1(c3ccccc3)C=C(C#N)C(=O)[C@@H](C)[C@@H]1CC2,,O,,C[O-].[Na+],,val
US20130225620A1,Fc1cc2c(cc1CNc1nccc(Nc3cc(C4CC4)[nH]n3)n1)ncn2C1CCCCO1>>Fc1cc2[nH]cnc2cc1CNc1nccc(Nc2cc(C3CC3)[nH]n2)n1,,CO,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140088075A1,CNc1cc2c(cn1)cc(-c1cc(NC(=O)Nc3cccc(F)c3)c(F)cc1Cl)c(=O)n2C(C)C.Cl>>CNc1cc2c(cn1)cc(-c1cc(NC(=O)Nc3cccc(F)c3)c(F)cc1Cl)c(=O)n2C(C)C.Cl,,CC#N,,,,val
US04269834,Cc1cccc(-c2cc3ccccc3c(=O)[nH]2)n1.O=C(Cl)c1ccccc1>>O=C(NC(Cc1ccccc1)c1ccccn1)c1ccccc1,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US20150148340A1,CI.CN(C)C=O.O=C1Cc2cc(Br)ccc2N1>>CN1C(=O)C(C)(C)c2cc(Br)ccc21,,C1CCOC1,,Cl,[H-].[Na+],val
US05155268,CCCCCCCN(CC)C(=O)Cc1ccc([N+](=O)[O-])cc1>>CCCCCCCN(CC)C(=O)Cc1ccc(N)cc1,[Pd],CO,,[H][H],,val
US20110009407A1,O=C(Nc1ccncc1)c1ccc[nH]c1=O.O=C1CCc2c1cccc2[N+](=O)[O-]>>O=C(Nc1ccncc1)c1cccn(C2CCc3c2cccc3[N+](=O)[O-])c1=O,,CN(C)C=O,O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100249229A1,CC12CC=CC1C(=O)C2.COP(=O)(CC(=O)OC(C)(C)C)OC>>CC(C)(C)OC(=O)C=C1C[C@]2(C)CC=C[C@@H]12,,O,,C1CCOC1,[H-].[Na+],val
US20020111492A1,CCOC(=O)C1(CCCc2c(F)cnc3ccc(OC)cc23)CCN(CCSc2cc(F)ccc2F)CC1>>COc1ccc2ncc(F)c(CCCC3(C(=O)O)CCN(CCSc4cc(F)ccc4F)CC3)c2c1,,C1COCCO1,CO,[Na+].[OH-],,val
US05076835,CSC1C(=O)Nc2ccc(Oc3ccc(C(F)(F)F)c(Cl)c3)cc21>>O=C1Cc2cc(Oc3ccc(C(F)(F)F)c(Cl)c3)ccc2N1,[Ni],CN(C)C=O,,CO,,val
US20140330009A1,C1COCCN1.CC(=O)N1CCC(=O)CC1>>CC(=O)N1CC=C(N2CCOCC2)CC1,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,,,val
US20070066624A1,CC(C)(C)OC(=O)CBr.Cc1nc(Oc2ccc(O)cc2)ccc1CN1CCC(N2C(=O)OC[C@H]2c2ccccc2)CC1>>Cc1nc(Oc2ccc(OCC(=O)OC(C)(C)C)cc2)ccc1CN1CCC(N2C(=O)OC[C@H]2c2ccccc2)CC1,,C1CCOC1,,[H-].[Na+],,val
US20130102587A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.c1cc2cc[nH]c2cn1>>CC(C)(C)OC(=O)N1CC=C(c2c[nH]c3cnccc23)CC1,,CO,,[K+].[OH-],,val
US20070185175A1,Fc1ccc(-c2ncoc2-c2ccc3nc(Br)sc3c2)cc1.NCCN1CCOCC1>>Fc1ccc(-c2ncoc2-c2ccc3nc(NCCN4CCOCC4)sc3c2)cc1,,C1CCOC1,,,,val
US20140296225A1,CC(C)(C)OC(=O)N1CCN(C2CCc3cc(C#N)ccc3C2)C(=O)C1>>N#Cc1ccc2c(c1)CC[C@H](N1CCNCC1=O)C2,,CCCCCCC,,CCO,,val
US05350748,CC(C)Oc1c(C(=O)O)oc2ccc(Cl)cc12.NCc1ccccc1>>CC(C)Oc1c(C(=O)NCc2ccccc2)oc2ccc(Cl)cc12,,C1CCOC1,CCOC(C)=O,O=C(n1ccnc1)n1ccnc1,,val
US20070185149A1,COc1cc2c(cc1OC)C1CC(OC(C)=O)CCC1N=C2c1ccc(C(=O)O)cc1.NCCN1CCOCC1>>COc1cc2c(cc1OC)C1CC(OC(C)=O)CCC1N=C2c1ccc(C(=O)NCCN2CCOCC2)cc1,CN(C)c1ccncc1,,,CCN=C=NCCCN(C)C,Cl,val
US20080312226A1,CC(C)(C)OC(=O)N1CCNCC1.COc1cccc(-c2csc(Br)n2)c1>>COc1cccc(-c2csc(N3CCN(C(=O)OC(C)(C)C)CC3)n2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090275037A1,CCc1nc(=O)c2ccccc2n1-c1ccccc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCc1nc(=S)c2ccccc2n1-c1ccccc1,,Cc1ccccc1,,,,val
US20090312306A1,CCI.COc1ccc2c(n1)CCN(Cc1ccccc1)CC2>>CCC1CNCCc2ccc(OC)nc21,,Cc1ccccc1,,[Li]CCCC,,val
US08350090B1,O=C(Cc1cccc(OCc2ccccc2)c1)c1ccco1>>OC(Cc1cccc(OCc2ccccc2)c1)c1ccco1,,CO,,[BH4-].[Na+],,val
US20040209917A1,COc1ccc(S)cc1.Cc1ccc(I)c(=O)[nH]1>>COc1ccc(Sc2ccc(C)[nH]c2=O)cc1,[Cu]I,CN(C)C=O,,[H-].[Na+],,val
US20160264598A1,CCCCO.O=C(CCc1cncs1)N[C@H]1Cc2cccc(C(=O)O)c2OB1O>>CCCCOC(=O)c1cccc2c1OB(O)C(NC(=O)CCc1cncs1)C2,,CCCCO,,,,val
US20140148601A1,CCCCCCOC(=O)n1ccnc1.CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C)c1ccccn1>>CCCCCCOC(=O)/N=C(\N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20090030006A1,O=C(O)c1ccc(C(=O)O)c(Br)c1>>OCc1ccc(CO)c(Br)c1,,C1CCOC1,,O,,val
US20040029874A1,CC(=O)C1CC1.Cc1ccc(NCC2CCNCC2)c(C(=O)Nc2ccc(Cl)cn2)c1>>Cc1ccc(NCC2CCN(C(C)C3CC3)CC2)c(C(=O)Nc2ccc(Cl)cn2)c1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20060189661A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.N#Cc1cc(Br)cc(-c2nc(-c3ccccn3)no2)c1>>N#Cc1cc(-c2ccccn2)cc(-c2nc(-c3ccccn3)no2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,,,val
US05436247,CCOC(=O)c1c(Cn2cncn2)nc2cc(OC)c(OC)cc2c1-c1ccc(OC)c(OC)c1>>COc1ccc(-c2c(C(=O)O)c(Cn3cncn3)nc3cc(OC)c(OC)cc23)cc1OC,,CCO,,Cl,[Na+].[OH-],val
US20030144283A1,CC(C)O.Cl.Nc1nc2ccccc2c2c1ncn2CCCCNC(=O)c1ccccc1>>Cl.Nc1nc2ccccc2c2c1ncn2CCCCNC(=O)c1ccccc1.O,,CC(C)O,,,,val
US20110152537A1,CCCC[N+](CCCC)(CCCC)CCCC.CCNCC.O=S(=O)([O-])CCCCCl>>CCCC[N+](CCCC)(CCCC)CCCC.CCN(CC)CCCCS(=O)(=O)[O-],,C1CCOC1,,,,val
US20110281865A1,O=C(NC1CC1)c1ccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1F.O=C(OO)c1cccc(Cl)c1>>O=C(NC1CC1)c1ccc(-c2ccc3nnn(Cc4ccc5c(ccc[n+]5[O-])c4)c3n2)cc1F,,ClCCl,,,,val
US08592463B2,CC(C)(C)OC(=O)N1CCN(C(=O)C2CCN(c3ccc(Cl)c(-c4nc5ccccc5[nH]4)c3)CC2)CC1>>O=C(C1CCN(c2ccc(Cl)c(-c3nc4ccccc4[nH]3)c2)CC1)N1CCNCC1,,CC(C)O,,CC(=O)Cl,,val
US20130274255A1,C[Si](C)(C)CCOCn1nc(-c2ccc(Br)cc2)c2c1-c1ccsc1C2.N#Cc1ccc(B(O)O)cc1>>C[Si](C)(C)CCOCn1nc(-c2ccc(-c3ccc(C#N)cc3)cc2)c2c1-c1ccsc1C2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20130317057A1,CC(C)(C)[Si](C)(C)OCCN.O=[N+]([O-])c1cc(F)c(F)cc1F>>CCNc1cc(F)c(F)cc1[N+](=O)[O-],,CC#N,,CCN(C(C)C)C(C)C,,val
US20100152168A1,CC(C)(C)OC(=O)C(Br)c1ccccc1.CC(C)(C)OC(=O)n1c(=O)[nH]c2cc(Cl)ccc21>>CC(C)(C)OC(=O)C(c1ccccc1)n1c(=O)n(C(=O)OC(C)(C)C)c2ccc(Cl)cc21,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],[Cl-].[NH4+],val
US06664380B1,C=O.OCCc1ccccc1>>c1ccc2c(c1)CCOC2,,CC(=O)O,ClCCl,,,val
US20090137557A1,CCC(C(=O)O)C1(C)OCCO1.NCCc1cccs1>>CCC(C(=O)NCCc1cccs1)C1(C)OCCO1,,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20070185185A1,Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)O)cc3c2CCO)c1.Oc1c(F)c(F)c(F)c(F)c1F>>Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)Oc4c(F)c(F)c(F)c(F)c4F)cc3c2CCO)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020091148A1,NNC(=O)c1[nH]c2ccccc2c1-c1ccsc1.O=Cc1cccnc1>>O=C(NN=Cc1cccnc1)c1[nH]c2ccccc2c1-c1ccsc1,,CCO,,,,val
US20130053397A1,COC(=O)c1cc(Br)cc2c1c(Cl)cn2C(C)C>>CC(C)n1cc(Cl)c2c(C(=O)O)cc(Br)cc21,,C1CCOC1,CO,[Na+].[OH-],,val
US04743685,NCc1cc(=O)c(OCc2ccccc2)cn1Cc1ccccc1.O=C=NCCCl>>O=C(NCCCl)NCC1(Cc2ccccc2)CC(=O)C(OCc2ccccc2)=CN1,,CCOC(C)=O,,,,val
US20070244131A1,CC(C)OB(OC(C)C)OC(C)C.O=C(O)Cc1c[nH]c2ccc(Br)cc12>>O=C(O)Cc1c[nH]c2ccc(B(O)O)cc12,,C1CCOC1,,[Li]C(C)(C)C,,val
US20030092677A1,CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2F)cc1NC(=O)CC(=O)c1cc(C#N)ccc1F>>N#Cc1ccc(F)c(C2=Nc3ccc(-c4ccccc4F)cc3NC(=O)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04929273,CCC(Oc1ccc(F)c(C(F)(F)F)c1)C(=O)Cl.NCc1ccccc1>>CCC(Oc1ccc(F)c(C(F)(F)F)c1)C(=O)NCc1ccccc1,,Cc1ccccc1,,c1ccncc1,,val
US20130029995A1,Nc1cncc2ccccc12.O=C(Cl)Oc1ccccc1>>O=C(Nc1cncc2ccccc12)Oc1ccccc1,,CC#N,O,c1ccncc1,,val
US20140323390A1,CCCCCCCCCCCC(=O)OC[C@H](CSC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)NCCCCCNC(=O)OCC1c2ccccc2-c2ccccc21)OC(=O)CCCCCCCCCCC>>CCCCCCCCCCCC(=O)OC[C@H](CSC[C@H](N)C(=O)NCCCCCN)OC(=O)CCCCCCCCCCC,,CC#N,,C1CCNCC1,,val
US20080096860A1,C1CC2(CCN1)OCCO2.NS(N)(=O)=O>>NS(=O)(=O)N1CCC2(CC1)OCCO2,,C1COCCO1,,,,val
US20130324579A1,COC(CCn1cc([N+](=O)[O-])cn1)OC>>O=CCCn1cc([N+](=O)[O-])cn1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20130102576A1,CC(C)(C)OC(=O)CN1C(=O)c2ccc(N)cc2C1=O.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)CN1C(=O)c2ccc(NS(C)(=O)=O)cc2C1=O,,C1CCOC1,,c1ccncc1,,val
US04939261,CC(C)(C)C(=O)OCOC(=O)[C@@H](Cc1ccccc1)C[C@H](Cc1ccccc1)C(=O)Cl.NCCC(=O)OCc1ccccc1>>CC(C)(C)C(=O)OCOC(=O)[C@@H](Cc1ccccc1)C[C@H](Cc1ccccc1)C(=O)NCCC(=O)OCc1ccccc1,,ClCCl,,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US06066641,CC(C)c1nc2c([nH]1)c(=O)[nH]c(=O)n2Cc1ccncc1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CC(C)c1nc2c([nH]1)c(=S)[nH]c(=O)n2Cc1ccncc1,,c1ccncc1,,[Na+].[OH-],,val
US20140073628A1,CC(N)=O.CC1(C)CCc2nc(CCl)nc(N3CCOc4ccc(Br)cc4C3)c2C1>>CC(=O)NCc1nc2c(c(N3CCOc4ccc(Br)cc4C3)n1)CC(C)(C)CC2,,CN(C)C=O,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20050239767A1,CC(C)(C)C(O)Cn1c(-c2ccccc2[N+](=O)[O-])nc2ccccc21>>CC(C)(C)C1Cn2c(nc3ccccc32)-c2ccccc2O1,,CN(C)C=O,,[H-].[Na+],,val
US20140163219A1,COC(=O)Cc1ccc(Cl)cc1C(=O)OC.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Cl)ccc1C(Br)C(=O)OC,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20090054425A1,Cc1ccc(S(=O)(=O)n2ccc3c(Nc4ccc5cn[nH]c5c4)nc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)cc1>>CN1CCN(c2ccc(Nc3nc(Nc4ccc5cn[nH]c5c4)c4cc[nH]c4n3)cc2)CC1,,CO,,[K+].[OH-],,val
US05212324,CCCCC(F)(F)C(=O)CC[C@H]1[C@H](OC2CCCCO2)CC(=O)[C@@H]1CCCCCCCCC(=O)OC(C)C>>CCCCC(F)(F)C(=O)CC[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCCCC(=O)OC(C)C,,C1CCOC1,,CC(=O)O,O,val
US20110124634A1,Cc1nc(CN2C(=O)Cc3c(Cl)nc(N)nc32)sc1C.O=Cc1cc(C(=O)O)c[nH]1>>Cc1nc(CN2C(=O)/C(=C\c3cc(C(=O)O)c[nH]3)c3c(Cl)nc(N)nc32)sc1C,,CCO,,C1CCNCC1,,val
US20160229816A1,CCOC(=O)c1csc(Nc2ccc(Cl)cc2)n1.CI>>CCOC(=O)c1csc(N(C)c2ccc(Cl)cc2)n1,,CN(C)C=O,,O,[H-].[Na+],val
US20080090822A1,C1CNCCN1.CC(=O)c1ccc(F)cc1C(F)(F)F>>CC(=O)c1ccc(N2CCNCC2)cc1C(F)(F)F,,CC#N,,,,val
US05462941,O=P(Cl)(Cl)Cl.O=c1[nH]nc(-c2cccs2)c2sccc12>>Clc1nnc(-c2cccs2)c2sccc12,,CC(Cl)Cl,,,,val
US05414002,COCc1c(C(=O)OC(C)C)ncc2[nH]c3ccc(OCc4ccccc4)cc3c12>>COCc1c(C(=O)OC(C)C)ncc2[nH]c3ccc(O)cc3c12,[Pd],CCO,,[H][H],,val
US20050256154A1,CCOC(=O)c1cnc(N)c2c(COc3ccc(OC)cc3Cl)csc12.NCCO>>COc1ccc(OCc2csc3c(C(=O)NCCO)cnc(N)c23)c(Cl)c1,,CS(C)=O,,O,,val
US20140234254A1,Clc1ccn2nccc2n1.O=C1CCC(=O)N1I>>Clc1ccn2ncc(I)c2n1,,CCOC(C)=O,CN(C)C=O,,,val
US20140296225A1,Cc1c(Br)ccc(F)c1C#N.O=C1CCC(=O)N1Br>>Cc1c(C(=O)CBr)ccc(F)c1C#N,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,C1COCCO1,,val
US20160145304A1,CC(C)O.O=[N+]([O-])c1cc(Br)c2c(c1O)OC(c1ccccc1)OC2>>CC(C)Oc1c([N+](=O)[O-])cc(Br)c2c1OC(c1ccccc1)OC2,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040142996A1,CC(C)(C)OC(=O)NCCC(O)CO[Si](C)(C)C(C)(C)C>>CC(C)(C)OC(=O)NCCC(=O)CO[Si](C)(C)C(C)(C)C,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20100310493A1,CCOC(=O)C(Br)c1ccc(S(=O)(=O)C2CC2)cc1.Oc1ccc(F)cc1F>>CCOC(=O)C(Oc1ccc(F)cc1F)c1ccc(S(=O)(=O)C2CC2)cc1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20100256357A1,Cc1nc(CCl)n(-c2ccc(S(N)(=O)=O)cc2F)n1.NCc1ccc(F)cc1>>Cc1nc(CNCc2ccc(F)cc2)n(-c2ccc(S(N)(=O)=O)cc2)n1,,CC#N,,,,val
US20010056100A1,COC(=O)[C@@H](Cc1ccccc1)NC(=O)OCc1ccc(COc2ccccc2)cc1>>O=C(N[C@H](Cc1ccccc1)C(=O)O)OCc1ccc(COc2ccccc2)cc1,,CO,O,[Li+].[OH-],,val
US20090093454A1,C[C@H]1CN[C@H](C)CN1.Fc1cccc2nc(CN3CCC[C@H]4CCc5cccnc5[C@H]43)cn12>>C[C@H]1CN(c2cccc3nc(CN4CCC[C@H]5CCc6cccnc6[C@H]54)cn23)[C@H](C)CN1,,CS(C)=O,,,,val
US20140275152A1,O=Cc1c(O)cccc1O.OC[C@@H]1CCCN1c1ccccc1>>O=Cc1c(O)cccc1OC[C@@H]1CCCN1c1ccccc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030199440A1,Brc1cccc(Br)n1.OCCOCc1ccccc1>>Brc1cccc(OCCOCc2ccccc2)n1,,Cc1ccccc1,O,[H-].[Na+],,val
US20160264567A1,CCOC(=O)c1c[nH]nc1N.FC(F)(F)c1ncc(Br)s1>>CCOC(=O)c1cn(-c2cnc(C(F)(F)F)s2)nc1N,[Cu]I,CS(C)=O,,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US06187805B1,CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(OCc3ccccc3)cc12>>CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12,[Pd],CCO,,Cl,,val
US04203988,CCOC(=O)Cl.Nc1ccc(Cl)c(N)n1>>CCOC(=O)Nc1ccc(Cl)c(N)n1,,O,,C1CCOC1,O=C([O-])O.[Na+],val
US20080146614A1,CNC.COC(=O)c1nn(-c2ccc(Cl)cc2Cl)c(-c2ccc(OC)cc2)c1CBr>>COC(=O)c1nn(-c2ccc(Cl)cc2Cl)c(-c2ccc(OC)cc2)c1CN(C)C,,CN(C)C=O,,,,val
US04496567,COc1ccccc1CSCCN.CSc1ncc(Cc2cccnc2)c(=O)[nH]1>>COc1ccccc1CSCCNc1ncc(Cc2cccnc2)c(=O)[nH]1,,O,,,,val
US20050203081A1,COC(=O)c1sc2ncccc2c1O.NC(=O)CBr>>COC(=O)c1sc2ncccc2c1OCC(N)=O,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20030125334A1,Clc1cncc(Cl)n1.N#Cc1cccc(CO)c1>>N#Cc1cccc(COc2cncc(Cl)n2)c1,,C1CCOC1,,Cl,[H-].[Na+],val
US04410528,CC(=O)Br.O=[N+]([O-])c1ccccc1NC1CCN(Cc2ccccc2)CC1>>Br.CC(=O)N(c1ccccc1[N+](=O)[O-])C1CCN(Cc2ccccc2)CC1,,C1COCCO1,,Cl,,val
US20120015962A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)CC1.Cl>>Cl.O=C(Nc1cc(Cl)ccc1OC1CCNCC1)c1cnn2cccnc12,,ClCCl,,,,val
US20110105436A1,CNC.Cc1cccc(Nc2nc(-c3ccnc(Br)c3)cs2)c1>>Cc1cccc(Nc2nc(-c3ccnc(N(C)C)c3)cs2)c1,,O,,,,val
US20060009493A1,COC(=O)Cc1ccc(OC)c(C#N)c1.NN>>COc1ccc(CC(=O)NN)cc1C#N,,CO,,CCOC(C)=O,O,val
US20150133451A1,Cn1cc(NC(=O)OC(C)(C)C)c(N2CC(CO)C(C)(C)C2=O)n1>>Cn1cc(NC(=O)OC(C)(C)C)c(N2CC(C=O)C(C)(C)C2=O)n1,,CC#N,CCOC(C)=O,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20080032985A1,CC(O)I.CCOC(=O)C(CCCc1c(F)cnc2ccc(OC)cc12)CNC/C=C/c1cc(F)ccc1F>>CCOC(=O)C(CCCc1c(F)cnc2ccc(OC)cc12)CN(C/C=C/c1cc(F)ccc1F)CCO,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060135530A1,CCOC(=O)C(=O)Cl.Cc1ccc(-c2c(CNC(=O)OC(C)(C)C)c(CC(C)C)nc3ccc(NCCNC(=O)OC(C)(C)C)cc23)cc1>>CCOC(=O)C(=O)N(CCNC(=O)OC(C)(C)C)c1ccc2nc(CC(C)C)c(CNC(=O)OC(C)(C)C)c(-c3ccc(C)cc3)c2c1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20070099990A1,Cc1cc2c(c(C)c1NCc1ccccc1)CCO2>>Cc1cc2c(c(C)c1N)CCO2,,CCCCCC,CCOC(C)=O,,,val
US20160024021A1,CNC(=O)c1cc(CCc2cnc(Nc3cnn(C4CCN(C(=O)OC(C)(C)C)CC4)c3)nc2)c(Cl)c(OC)c1>>CNC(=O)c1cc(CCc2cnc(Nc3cnn(C4CCNCC4)c3)nc2)c(Cl)c(OC)c1,Cl,CO,,,,val
US20050107449A1,COC(=O)C(NC(=O)c1ccc(C(F)(F)F)cc1)C(C)C>>CC(C)C1N=C(c2ccc(C(F)(F)F)cc2)OC1=O,,CC(=O)OC(C)=O,,,,val
US20110059942A1,CS(=O)(=O)OC1CN(Cc2ccc(C(F)(F)F)cc2)C1.Oc1ccc(Br)nc1>>FC(F)(F)c1ccc(CN2CC(Oc3ccc(Br)nc3)C2)cc1,,CS(C)=O,,O,CC(C)(C)[O-].[K+],val
US20040014766A1,CC=O.Nc1ccc(Cc2nc3c([nH]2)c(=O)n(Cc2ccccc2F)c(=O)n3CC2CC2)cc1>>CCNc1ccc(Cc2nc3c([nH]2)c(=O)n(Cc2ccccc2F)c(=O)n3CC2CC2)cc1,[Pd],C1CCOC1,,,,val
US20090198070A1,CC(C)[C@H](N)CO.O=C(CCc1ccccc1)OCc1ccccc1>>CC(C)[C@H]1COC(CCc2ccccc2)=N1,,Clc1ccccc1,,,,val
US20130236434A1,CCOC(=O)C[C@H](N)c1ccccc1>>COC(=O)C[C@H](N)c1ccccc1,,CO,,Cl,O=C([O-])O.[Na+],val
US20060217372A1,Cl.NC(=O)c1ccc(Oc2ccc(C3=CCCN(Cc4ccccc4)C3)cc2)nc1>>Cl.NC(=O)c1ccc(Oc2ccc(C3CCCNC3)cc2)nc1,[Pd],CO,,,,val
US20120093767A1,CC(C)(C)OC(=O)NCCCCCCCCN.COC(=O)c1ccc(Nc2nc(Cl)nc(OCC(F)(F)F)n2)cc1OCCCCl>>COC(=O)c1ccc(Nc2nc(NCCCCCCCCNC(=O)OC(C)(C)C)nc(OCC(F)(F)F)n2)cc1OCCCCl,,C1CCOC1,ClCCl,,,val
US20120270866A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCn1c(=O)c(Br)cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc21>>CCn1c(=O)c(B(O)O)cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,,CC(=O)[O-].[K+],,val
US20100160280A1,Clc1ccccn1.Nc1ccc(Oc2ncccc2Br)cc1>>Brc1cccnc1Oc1ccc(Nc2ccccn2)cc1.Cl,,CCOCC,,,,val
US20140080808A1,CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(C3(c4ccc(-c5nccs5)cc4)CC3)n2CCS1>>CC1(CO)Cc2nnc(C3(c4ccc(-c5nccs5)cc4)CC3)n2CCS1,,CO,,Cl,,val
US20120258982A1,COC(=O)c1ccc(/C=C/C(=O)c2ccc(C(F)(F)F)nc2Nc2ccccc2)cc1>>COC(=O)c1ccc(CCC(=O)c2ccc(C(F)(F)F)nc2Nc2ccccc2)cc1,[Pd],CC(C)=O,,[H][H],,val
US06277872B1,CN(C)CCOc1ccccc1C(=O)O.N=C=N.Oc1cccc2[nH]nnc12>>CN(C)CCOc1ccccc1-c1nc(-c2ccc(O)cc2)no1,,CN(C)C=O,,Cl,,val
US20100029650A1,CC(C)(C)OC(=O)N1CCC(COc2ccc(-c3ccc(S(C)(=O)=O)cc3)nc2)CC1.O=C(Cl)OCCF>>CS(=O)(=O)c1ccc(-c2ccc(OCC3CCN(C(=O)OCCF)CC3)cn2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20130225580A1,CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.Cc1cc(N)n(-c2cncc3ccccc23)n1>>Cc1cc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)n(-c2cncc3ccccc23)n1,,c1ccncc1,,,,val
US20120295874A1,CCOC(=O)COc1ccc(CNC(=O)c2ccc(CNC(=O)OC(C)(C)C)cc2)cc1>>CC(C)(C)OC(=O)NCc1ccc(C(=O)NCc2ccc(OCC(=O)O)cc2)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20100311750A1,COC[C@@H]1C[C@H](Nc2ncc(Br)cn2)CN1C(=O)OC(C)(C)C.FC(F)(F)c1cc(CBr)cc(C(F)(F)F)c1>>COC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(Br)cn2)CN1C(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20050153977A1,CCN(CC)CC.COC(=O)Cl.O=Cc1ccc(C(=O)Nc2nc(-c3ccc(F)cc3)c(N3CCN(C4CCCCC4)CC3)s2)cc1>>COC(=O)NCc1ccc(C(=O)Nc2nc(-c3ccc(F)cc3)c(N3CCN(C4CCCCC4)CC3)s2)cc1,,C1CCOC1,,,,val
US20080194557A1,Clc1nccc2ccccc12.Nc1cccc(Cl)c1>>Clc1cccc(Nc2nccc3ccccc23)c1,Cl,CC(C)O,,,,val
US07015218B1,CC(C)(C)COc1ccc(N)cc1C#N.Cn1nc(-c2ccccc2)cc1C(=O)O>>Cn1nc(-c2ccccc2)cc1C(=O)Nc1ccc(OCC(C)(C)C)c(C#N)c1,,CN(C)C=O,O,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US04431808,ClCCCN1CCCCC1.O=S1(=O)Cc2cc(Cl)ccc2Oc2ccccc21>>O=S1(=O)c2ccccc2Oc2ccc(Cl)cc2C1CCCN1CCCCC1,,CN(C)C=O,O,CCO,[H-].[Na+],val
US04360680,COc1ccc(NN)cc1.N#CC=Cc1ccccc1>>COc1ccc(N2N=C(N)CC2c2ccccc2)cc1,,CCO,,Cl,[Na],val
US20110201643A1,O=C(NOC1CCCCO1)c1ccc2c(c1)CNCC2.O=C(O)Cc1ccccn1>>O=C(NOC1CCCCO1)c1ccc2c(c1)CN(C(=O)Cc1ccccn1)CC2,,CCN(CC)CC,CN(C)C=O,ClCCCl,On1nnc2ccccc21,val
US20040077726A1,COC(=O)C=Cc1cccc(S(=O)(=O)Cl)c1.COc1cccc(N)c1>>COC(=O)C=Cc1cccc(S(=O)(=O)Nc2cccc(OC)c2)c1,,C1COCCO1,O,O=C([O-])O.[Na+],,val
US04666907,COc1ccc2c(c1Cl)Sc1ccccc1N2C.OO>>COc1ccc2c(c1Cl)S(=O)c1ccccc1N2C,,CC(=O)O,,,,val
US20160185768A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.C[C@@H]1CC[C@@H](C(N)=O)CN1C(=O)OCC1c2ccccc2-c2ccccc21>>C[C@@H]1CC[C@@H](C(N)=S)CN1C(=O)OCC1c2ccccc2-c2ccccc21,,C1CCOC1,,,,val
US04288244,CC(C)(C)C(Br)C(=O)Cl.NC1(c2ccccc2)CC1>>CC(C)(C)C(Br)C(=O)NC1(c2ccccc2)CC1,,CCN(CC)CC,,c1ccccc1,,val
US04918200,C=CCOCC=C.C[SiH](C)Cl.Cc1cc(=O)oc2cc(O)ccc12>>Cc1cc(=O)oc2cc(OCCC[Si](C)(C)Cl)ccc12,,C1CCOC1,,Cc1ccccc1,,val
US20070112000A1,CC(C)(C)OC(=O)N1CCCC(C(=O)O)C1.CNOC>>CON(C)C(=O)C1CCCN(C(=O)OC(C)(C)C)C1,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US04165372,Brc1c2c(cc3c1OCO3)C(c1ccccc1)CNCC2.CN(C=O)c1ccccc1>>O=Cc1c2c(cc3c1OCO3)C(c1ccccc1)CNCC2,,CCOCC,Cc1ccccc1,[Li]CCCC,,val
US20050032816A1,O=C(Nc1cc2ccccc2cn1)c1ccccc1NCc1ccncc1.O=C(OO)c1cccc(Cl)c1>>O=C(c1ccccc1NCc1ccncc1)[NH+]([O-])c1cc2ccccc2cn1,,ClCCl,,,,val
US20130053409A1,C=CC(=O)Cl.COc1cc(N2CCN(C)CC2)c(N)cc1Nc1ncc(C#N)c(-c2cnn3ccccc23)n1>>C=CC(=O)Nc1cc(Nc2ncc(C#N)c(-c3cnn4ccccc34)n2)c(OC)cc1N1CCN(C)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110294829A1,Cc1nsnc1C(=O)c1ccccc1.NO>>Cc1nsnc1C(=NO)c1ccccc1,,c1ccncc1,,Cl,,val
US20160251311A1,Cc1ccc(S(=O)(=O)N[C@@H](C)C(=O)O)cc1>>Cc1ccc(S(=O)(=O)N[C@@H](C)C(=O)O)cc1,,O,,Cl,,val
US20120157494A1,CC(C)(C)OC(=O)NCc1cncs1.O=C1OC(=O)c2c(F)cccc21>>O=C1c2cccc(F)c2C(=O)N1Cc1cncs1,,CC(=O)O,,,,val
US20040116509A1,COC(=O)c1sc(-c2ccccc2)cc1N.O=C(Cl)c1ccc(Cl)cc1Cl>>COC(=O)c1sc(-c2ccccc2)cc1NC(=O)c1ccc(Cl)cc1Cl,,ClCCl,,CCN(CC)CC,,val
US20010051631A1,CC(C)(C)OC(=O)N(CCCNS(=O)(=O)C(F)(F)F)Cc1cccc2ncc(C(=O)C(Cl)(Cl)Cl)n12.CO>>COC(=O)c1cnc2cccc(CN(CCCNS(=O)(=O)C(F)(F)F)C(=O)OC(C)(C)C)n12,,Cl,,C[O-].[Na+],,val
US20090181942A1,COc1cccc(C=O)c1F.Clc1ccc(-n2cccc2)c(Br)c1>>COc1cccc(C(O)c2cc(Cl)ccc2-n2cccc2)c1F,,CCOC(C)=O,CCOCC,[Li]CCCC,[Cl-].[NH4+],val
US20110053893A1,CCOP(=O)(OCC)C(F)P(=O)(OCC)OCC.COc1ccc(CCc2cnc3c(N)nc4cc(C=O)ccc4c3c2)c(C)c1>>CCOP(=O)(OCC)/C(F)=C/c1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OC)cc3C)cc12,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20070213336A1,CCCCCCCNC(=O)N(C)c1ccc(C)c(-c2ccc(/C=C/C(=O)OCC)cc2)c1>>CCCCCCCNC(=O)N(C)c1ccc(C)c(-c2ccc(CCC(=O)OCC)cc2)c1,[Pd],CO,,,,val
US20090036444A1,CCO.COC(=O)c1cc([N+](=O)[O-])c(C)s1.O=Cc1ccc(OCc2ccccc2)cc1>>CCOC(=O)c1cc([N+](=O)[O-])c(/C=C/c2ccc(OCc3ccccc3)cc2)s1,,CCO,,C1CCNC1,,val
US20020055504A1,O=C(CCl)NCc1cccc2c3c([nH]c12)CCC3>>O=C1Cn2c3c(c4cccc(c42)CN1)CCC3,,CN(C)C=O,,O,[H-].[Na+],val
US20070191414A1,CCOc1cc2c(cc1OC)C(c1cccc(NC(=O)COC)c1)=NC1CCC(OC(C)=O)CC21>>CCOc1cc2c(cc1OC)C(c1cccc(NC(=O)COC)c1)=NC1CCC(O)CC21,,CO,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140179667A1,CCOc1ccc(O)c(C(=O)N(CCO)Cc2c(C)cc(C)nc2OCc2ccccc2)c1C>>CCOc1ccc2c(c1C)C(=O)N(Cc1c(C)cc(C)nc1OCc1ccccc1)CCO2,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100286120A1,O=C1c2ccc(F)nc2OCCN1Cc1ccccc1.Oc1ccc(Cl)cc1>>O=C1c2ccc(Oc3ccc(Cl)cc3)nc2OCCN1Cc1ccccc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05340820,CCC(=O)C(=CS(=O)(=O)c1ccc(OS(=O)(=O)c2ccc(C)cc2)cc1)N(C)C.CNN>>CCc1c(S(=O)(=O)c2ccc(O)cc2)cnn1C,,CO,,O,,val
US04888345,CN(C)C=CC(=O)c1cccc(Cl)c1.NC(=O)c1[nH]cnc1N>>NC(=O)c1ncn2c(-c3cccc(Cl)c3)ccnc12,,CC(=O)O,,Cl,O=C([O-])O.[Na+],val
US20060111311A1,COC1O[C@H](COCc2ccc(Cl)cc2Cl)[C@@H](OCc2ccc(Cl)cc2Cl)[C@H]1OCc1ccc(Cl)cc1Cl>>COC1O[C@H](COCc2ccc(Cl)cc2Cl)[C@@H](OCc2ccc(Cl)cc2Cl)[C@H]1O,,ClCCl,,,,val
US03931226,BrCCCCBr.NC1=Nc2ccccc2C1(O)c1cccc(Cl)c1>>OC1(c2cccc(Cl)c2)C2=NCCCCN2c2ccccc21,,CCO,,Cl,,val
US20030087901A1,COc1ccc2c(c1)CCNC2Cc1ccc(OCc2ccccc2)cc1.Clc1ccnc(Cl)n1>>COc1ccc2c(c1)CCN(c1ccnc(Cl)n1)C2Cc1ccc(OCc2ccccc2)cc1,,CCO,,O=C([O-])O.[Na+],,val
US20150191486A1,COCCCCN(C(=O)OC(C)(C)C)c1cccc(OC)c1[N+](=O)[O-]>>COCCCCNc1cccc(OC)c1[N+](=O)[O-],,CCOC(C)=O,,Cl,,val
US20140235628A1,N#Cc1cc(CCC2(O)CCNCC2)ccc1F.O=C1OCc2cc(CCBr)ccc21>>N#Cc1cc(CCC2(O)CCN(CCc3ccc4c(c3)COC4=O)CC2)ccc1F,,CCO,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US04638067,CCNCC1CCNC1.CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)c(F)c21>>CCNCC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(CC)c3c2F)C1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20090324581A1,CS(=O)(=O)Cl.OCCCc1ccc(F)cc1F>>CS(=O)(=O)OCCCc1ccc(F)cc1F,,ClCCl,,,,val
US05182288,COC(=O)c1ccccc1Cc1ccc(CN)cc1>>NCc1ccc(Cc2ccccc2C(=O)O)cc1,,CO,,[K+].[OH-],,val
US04657915,Cc1c[nH]cn1.Cc1cc2[nH]c(=O)ccc2c(Br)n1>>Cc1cn(-c2nc(C)cc3[nH]c(=O)ccc23)cn1,,O,,CN1CCCC1=O,,val
US20150329542A1,CC(C)=O.CI.CN(c1ccccc1CN)S(C)(=O)=O>>CC(=O)c1ccccc1N(C)S(C)(=O)=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140296225A1,N#Cc1ccc2c(c1)CCC(N1CCNCC1=O)C2.O=C(O)Cc1ccc(-n2cnnn2)cc1>>N#Cc1ccc2c(c1)CCC(N1CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC1=O)C2,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US05051361,Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)n(CCCN)c1=O>>Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O,,CO,,CCN(CC)CC,,val
US20030008882A1,COc1ccc(-c2ccc(-c3ccc(CCC#N)cc3CC(C)C)cc2CC(C)C)cc1Cc1cccc2ccccc12>>CC(C)Cc1cc(CCC#N)ccc1-c1ccc(-c2ccc(O)c(Cc3cccc4ccccc34)c2)c(CC(C)C)c1,,ClCCl,,BrB(Br)Br,O,val
US20070149585A1,NC1COc2ccc3c(c2C1)C(=O)NC3.O=CCCCc1c[nH]c2ccc(F)cc12>>O=C1NCc2ccc3c(c21)CC(NCCCCc1c[nH]c2ccc(F)cc12)CO3,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20020156054A1,CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(c2ccc(C(F)(F)F)cc2)=CCC3(C)C)cc1>>CC1(C)CC=C(c2ccc(C(F)(F)F)cc2)c2cc(C#Cc3ccc(C(=O)O)cc3)ccc21,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20150376130A1,COC(=O)c1cccnc1NC1CC(F)(F)C1>>O=C(O)c1cccnc1NC1CC(F)(F)C1,,CO,O,[K+].[OH-],,val
US20140073620A1,CC(C)n1cc(N)cn1.NC(=O)C1(c2ccccc2CCc2nc(Cl)ncc2Cl)CC1>>CC(C)n1cc(Nc2ncc(Cl)c(CCc3ccccc3C3(C(N)=O)CC3)n2)cn1,,C1COCCO1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US05736548,CCCOc1ccccc1-c1nc2n(C(C)(C)C)[nH]cc-2c(=O)n1>>CCCOc1ccccc1C1=NC(=O)C2=CN=NC2=N1,,O=C(O)C(F)(F)F,,,,val
US20040142981A1,O=C(O)c1ccc(S(=O)(=O)Cl)cc1.c1ccc2c(c1)CCN2>>O=C(O)c1ccc(S(=O)(=O)N2CCc3ccccc32)cc1,,CO,,CCN(CC)CC,,val
US04036965,COC(=O)c1ccc([N+](=O)[O-])c(C)n1.FC(F)(F)c1cccc(CS)c1>>COC(=O)c1ccc(SCc2cccc(C(F)(F)F)c2)c(C)n1,,CN(C)C=O,,CC(=O)O,[H-].[Na+],val
US20070032485A1,CC[C@@H]1C[C@H](Nc2ncc(O)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)c2nc(OC)ccc2N1C(=O)OCC(C)(C)C(=O)OC.COCCO>>CC[C@@H]1C[C@H](Nc2ncc(OCCOC)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)c2nc(OC)ccc2N1C(=O)OCC(C)(C)C(=O)OC,,C1CCOC1,Cc1ccccc1,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150307497A1,Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.N#Cc1ccc(Br)nc1>>Cn1cc(-c2ccc(C#N)cn2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US20160215070A1,O=C(N[C@@H](Cc1ccccc1)C(=O)O)OCc1ccccc1.O=S(Cl)Cl>>O=C(N[C@@H](Cc1ccccc1)C(=O)Cl)OCc1ccccc1,,ClCCl,,,,val
US20050043336A1,CS(=O)(=O)Cl.Cc1nc(CO)co1>>Cc1nc(COS(C)(=O)=O)co1,,ClCCl,,CCN(CC)CC,,val
US20060276626A1,CC(=O)[O-].CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O>>CC(=O)O.CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O,,CC#N,,,,val
US06403602B1,CC(=O)OC(C)=O.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5>>CC(=O)Oc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341,,O=C([O-])O,[Na+],,,val
US06162808,O=C(O)c1ccc(Br)cc1C=Cc1cccc(Br)c1>>O=C(O)c1ccc(Br)cc1CCc1cccc(Br)c1,O=[Pt]=O,Cc1ccccc1,,[H][H],,val
US20150291595A1,CB1OB(C)OB(C)O1.CC(C)(C)OC(=O)N[C@@H](CCOCc1ccccc1)c1nn2ccc(Br)c2c(=O)n1-c1ccccc1>>Cc1ccn2nc([C@H](CCOCc3ccccc3)NC(=O)OC(C)(C)C)n(-c3ccccc3)c(=O)c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160264578A1,CCN=C=O.COc1cccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(N)cc4)cn3n(Cc3c(F)cccc3F)c2=O)c1F>>CCNC(=O)Nc1ccc(-c2cn3c(c2CN(C)C)c(=O)n(-c2cccc(OC)c2F)c(=O)n3Cc2c(F)cccc2F)cc1,,C1CCOC1,,,,val
US20140142083A1,CI.COC(=O)c1cccc(NC2CCCC2)c1Br>>COC(=O)c1cccc(N(C)C2CCCC2)c1Br,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04873236,CC(C)N(CCCC1CCN(CCN)CC1)C(C)C.Cc1ccc2c(c1)N(C(=O)Cl)c1ncccc1NC2=O>>Cc1ccc2c(c1)N(C(=O)NCCN1CCC(CCCN(C(C)C)C(C)C)CC1)c1ncccc1NC2=O,,CCOC(C)=O,,,,val
US05250526,C1CNCCN1.O=C(NCCCCCCCCCCCO)c1ccc(Cl)nc1>>O=C(NCCCCCCCCCCCO)c1ccc(N2CCNCC2)nc1,,Cc1ccccc1,,,,val
US20120046292A1,BrCc1ccccc1.O=C(O)c1ccc(O)c(F)c1>>O=C(OCc1ccccc1)c1ccc(O)c(F)c1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05514680,Nc1ccc(C(F)(F)F)c(C(F)(F)F)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1ccc(C(F)(F)F)c(C(F)(F)F)c1)C(F)(F)F,,C1COCCO1,,O,,val
US20130116243A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)N(CCO)C(=O)CO4)cc2)CCC1>>NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)N(CCO)C(=O)CO4)cc2)CCC1,,ClCCl,,Cl,,val
US05466692,CC(C)(C)n1nnnc1-c1ccccc1B(O)O.CC1Cc2cnc(CO)nc2N(Cc2ccc(Br)cc2)C1=O>>Cc1nc(CO)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nnnn2C(C)(C)C)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,ClCCl,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20110183988A1,Nc1cccc(C(=O)c2c[nH]c3ncc(Br)cc23)c1F.O=S(=O)(Cl)c1ccccc1F>>O=C(c1cccc(NS(=O)(=O)c2ccccc2F)c1F)c1c[nH]c2ncc(Br)cc12,,C1CCOC1,,Cl,c1ccncc1,val
US20120165347A1,CC(=O)C(N)=S.N=C1CC2(CCCOC2)Oc2ccc(Br)cc21>>CC1=NC2(CC3(CCCOC3)Oc3ccc(Br)cc32)NC1=S,,CC#N,,,,val
US03980795,Cc1cc(=O)[nH][nH]1.Fc1ccc(-c2ccc(Br)cc2)cc1>>CC1(c2ccc(-c3ccc(F)cc3)cc2)CC(=O)NN1,,C1CCOC1,CCOCC,Cl,[Mg],val
US20060293354A1,CCN(CC)CC.NCC1CCOCC1.O=C(Cl)c1cnc(Cl)nc1C(F)(F)F>>CCCC(C)C.O=C(NCC1CCOCC1)c1cnc(Cl)nc1C(F)(F)F,,ClCCl,,,,val
US20130310377A1,NN.O=C(/C=C(\O)C(F)F)C1CC1>>FC(F)c1cc(C2CC2)[nH]n1,,CCO,,Cl,O,val
US06743800B1,CC(C)(C)OC(=O)[C@H](Cn1cnc2c(Cl)ncnc21)NC(=O)OCc1ccccc1.c1cc2c(nc1C1CCNCC1)NCCC2>>CC(C)(C)OC(=O)[C@H](Cn1cnc2c(N3CCC(c4ccc5c(n4)NCCC5)CC3)ncnc21)NC(=O)OCc1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20030004360A1,CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CCl>>CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H]1CO1,,CCO,,O,[K+].[OH-],val
US04933355,C=CCNC(N)=S.CCOC(=O)C(=O)CBr>>C=CCNc1nc(C(=O)OCC)cs1,,CCO,,,,val
US20150258074A1,CI.COc1ccc(CN(Cc2ccc(OC)cc2)[C@@H](c2ccccc2)C(C)(C)O)cc1>>COc1ccc(CN(Cc2ccc(OC)cc2)[C@@H](c2ccccc2)C(C)(C)OC)cc1,,C1CCOC1,,[H-].[Na+],,val
US20140249120A1,C=C1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](OC)C[C@]4(C)[C@H]3CC[C@]12C.COCCl>>C=C1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](OCOC)[C@@H](OC)C[C@]4(C)[C@H]3CC[C@]12C,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US04562294,C=CC=C.Cc1cc(CN(C)C)cc(C)c1O>>CC1=CC2(C=C(C)C1=O)CC=CCC2,,Cc1ccccc1,,,,val
US20040077701A1,CCc1c(-c2ccc(O)cc2)nn(C2CCC2)c1-c1ccc(O)cc1.COS(=O)(=O)OC>>CCc1c(-c2ccc(O)cc2)nn(C2CCC2)c1-c1ccc(OC)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04125729,O=C(O)Cc1ccc(I)cc1.Sc1ccc(Cl)cc1>>O=C(O)Cc1ccc(Sc2ccc(Cl)cc2)cc1,[Cu],O,,[K+].[OH-],,val
US20090062280A1,CCOC(=O)C(=O)C(C)C.COc1ccc(N)c(N)c1>>COc1ccc2nc(C(C)C)c(=O)[nH]c2c1,,CC(=O)O,,,,val
US20090253677A1,CN(C(=O)OCc1ccccc1)C(C#N)C1CCC(CO)C1.NO>>CN(C(=O)OCc1ccccc1)C(C(N)=NO)C1CCC(CO)C1,,CCO,,,,val
US20020111358A1,CCOC(=O)c1cc2c(OCc3ccccc3)cccc2[nH]1>>O=C(O)c1cc2c(OCc3ccccc3)cccc2[nH]1,,C1COCCO1,O,Cl,[K+].[OH-],val
US20140179698A1,CO.Cc1ccc(CCl)cc1[N+](=O)[O-]>>COCc1ccc(C)c([N+](=O)[O-])c1,,CO,,O,C[O-].[Na+],val
US20110190266A1,Cn1ncnc1CC1(O)OC(=O)C2=C1C(N)CCC2.O=C(O)[C@@H]1CCCN1.O=Cc1ccc(F)cc1>>Cn1ncnc1C1C(=O)C2=C(C(=O)O)CCCC2NC1c1ccc(F)cc1,,CO,ClCCl,,,val
US20040053942A1,COc1ccn2nc(-c3ccc(F)cc3)c(-c3ccncc3)c2c1>>Oc1ccn2nc(-c3ccc(F)cc3)c(-c3ccncc3)c2c1,,ClCCl,,BrB(Br)Br,,val
US20070149561A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCn1cc(Br)c(-c2ccc([N+](=O)[O-])cc2)n1>>CCn1cc(B2OC(C)(C)C(C)(C)O2)c(-c2ccc([N+](=O)[O-])cc2)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,CC(=O)[O-].[K+],,val
US20040204618A1,Cc1ccc(S(=O)(=O)OC(C)COCc2ccccc2)cc1.OCCCCO>>CC(COCc1ccccc1)OCCCCO,,C1COCCO1,,O,[K+].[OH-],val
US20040106615A1,COB(O)c1ccc(C(=O)O)cc1.Fc1cnc(Cl)nc1Cl>>COC(=O)c1ccc(-c2nc(Cl)ncc2F)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20070225261A1,CC(=O)OC(C)=O.COc1c(C)c(C)c(OC)c(C/C=C(\C)CCCCO)c1C>>COc1c(C)c(C)c(OC)c(C/C=C(\C)CCCCOC(C)=O)c1C,,c1ccncc1,,,,val
US20040127555A1,CC(=O)c1ccc2c(c1)OCO2.O=Cc1ccc2c(c1)OCO2>>O=C(C=Cc1ccc2c(c1)OCO2)c1ccc2c(c1)OCO2,,CCO,,[Na+].[OH-],,val
US20160176850A1,CCOC(C)=O.Nc1ncccc1O>>CCOC(=O)Nc1ncccc1O,CN(C)c1ccncc1,ClCCl,,CCCCCC,,val
US04687863,CC1(C)C=CC[C@]2(C)OC(=O)C[C@H]12>>CC1(C)CCC[C@]2(C)OC(=O)C[C@H]12,O=[Pt],CC(=O)O,,,,val
US04859692,COC(=O)c1ccc(CBr)c(OC)c1.O=[N+]([O-])c1ccc2c(c1)NCCO2>>COC(=O)c1ccc(CN2CCOc3ccc([N+](=O)[O-])cc32)c(OC)c1,,CC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20120015962A1,CC(C)(C)OC(=O)N1CCC(C=O)C1.C[Mg]I>>CC(O)C1CCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,,,val
US04073898,N#C[O-].NCCS(=O)CC(O)CO>>NC(=O)NCCS(=O)CC(O)CO,,O,,Cl,,val
US20040102437A1,Nc1ccncc1.O=C=Nc1ccc(Cl)cc1Cl>>O=C(Nc1ccncc1)Nc1ccc(Cl)cc1Cl,,Cc1ccccc1,,,,val
US08906953B2,CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4cccc(Cl)c4Cl)oc23)[C@@H]1CO.Cl>>CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4cccc(Cl)c4Cl)oc23)[C@@H]1CO.Cl,,CO,,,,val
US06576766B1,COC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O.O=C1CCC(=O)N1Br>>COC(=O)C(Cc1ccc(O)c(Br)c1)NC(C)=O,O=S(=O)(O)O,C1CCOC1,,,,val
US05041448,COc1ccc(CCCl)cc1.c1ccc(Cn2c(NC3CCNCC3)nc3cncnc32)nc1>>COc1ccc(CCN2CCC(Nc3nc4cncnc4n3Cc3ccccn3)CC2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20090005535A1,C=CCOC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)OC(C)(C)C>>CC(C)C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)OC(C)(C)C)C(=O)O,,CCO,O,[Na+].[OH-],,val
US20060148811A1,COc1ccc(CN2CCNCC2)cc1.COc1ccc2cc(C(=O)C(C)Cl)ccc2c1Cl.Cl.Cl>>COc1ccc(CN2CCN(C(C)C(=O)c3ccc4c(Cl)c(OC)ccc4c3)CC2)cc1.Cl.Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040242884A1,CCOC(=O)c1cn(C)c2c(C)c(CO)sc2c1=O.NCc1ccc(Cl)cc1>>Cc1c(CO)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12,,CO,,C[O-].[Na+],,val
US03987047,CC(=O)N1CCCc2nc3ccccc3c(C)c2C1.OO>>CC(=O)N1CCCc2c(c(C)c3ccccc3[n+]2[O-])C1,,CC(=O)O,,,,val
US20090062552A1,CC(C)C(=O)C(C)c1ccccc1[N+](=O)[O-]>>CC(C)C(O)C(C)c1ccccc1[N+](=O)[O-],,CO,,Cl,[BH4-].[Na+],val
US20140296246A1,Cc1noc(C)c1-c1cc(N)c(N)c(S(=O)(=O)NC2CCCC2)c1.O=C(n1ccnc1)n1ccnc1>>Cc1noc(C)c1-c1cc(S(=O)(=O)NC2CCCC2)c2[nH]c(=O)[nH]c2c1,,CN(C)C=O,,,,val
US04152441,COCn1ccnc1C(O)(c1ccc(Cl)cc1Cl)c1ccc(Cl)cc1Cl>>OC(c1ncc[nH]1)(c1ccc(Cl)cc1Cl)c1ccc(Cl)cc1Cl,,O,,CC(=O)O,Cl,val
US20090163524A1,CC(C)(C)OC(=O)NC(CCCO)c1ccc(Cl)cc1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)NC(CCCOS(C)(=O)=O)c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20050222308A1,CCCCC(CC)(CO)CO.CCCCCCCCCC1CCC(O)CC1.ClP(Cl)Cl>>CCCCCCCCCC1CCC(OP2OCC(CC)(CCCC)CO2)CC1,,Cc1ccccc1,,CCN(CC)CC,,val
US20020099068A1,CC(=O)OC(C)=O.Clc1ccc2c(c1)[nH]c1cnccc12>>CC(=O)c1nccc2c1[nH]c1cc(Cl)ccc12,,CN(C)C=O,,O,[H-].[Na+],val
US20040097508A1,CCOC(=O)c1csc(N)n1.O=C(Cl)c1ccc2ccccc2c1>>CCOC(=O)c1csc(NC(=O)c2ccc3ccccc3c2)n1,,C1CCOC1,,CCN(CC)CC,O,val
US20150182531A1,CNCCC(NC(=O)OC(C)(C)C)c1ccc(Cl)cc1>>CNCCC(N)c1ccc(Cl)cc1,,CO,ClCCl,Cl,,val
US20130331409A1,Nc1nc2cccnc2n1-c1ccc(OCc2ccccc2)cc1.O=CCCl>>c1ccc(COc2ccc(-n3c4ncccc4n4ccnc34)cc2)cc1,,CC(=O)N(C)C,,O,,val
US20150175624A1,CC(C)OB(OC(C)C)OC(C)C.O=P(O)(O)O.c1cc2ccsc2cn1>>O=P(O)(O)O.OB(O)c1cc2ccncc2s1,,O,,[Li]CCCC,,val
US20140010783A1,CI.CS/C(=N\C#N)Nc1cc(Cl)c(Cl)c(Cl)c1>>CS/C(=N\C#N)N(C)c1cc(Cl)c(Cl)c(Cl)c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20020028832A1,CC(C)(C)[Si](Oc1ccc(OCC2CO2)cc1)(c1ccccc1)c1ccccc1.CN(C)C(=O)Oc1ccc(CCNC(=O)N2CCC(Nc3ccc(CCN)cc3)CC2)cc1>>CN(C)C(=O)Oc1ccc(CCNC(=O)N2CCC(Nc3ccc(CCNC[C@H](O)COc4ccc(O)cc4)cc3)CC2)cc1,,CO,ClC(Cl)Cl,O=CO,,val
US05393761,Cc1ccc2c(c1)c(-c1ccc(F)cc1)c(C)n2C1=CCN(CCN2CCNC2=O)CC1>>Cc1ccc2c(c1)c(-c1ccc(F)cc1)c(C)n2C1CCN(CCN2CCNC2=O)CC1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20150141406A1,Cl.O=c1[nH]cc(Cl)c2c1c(-c1ccc(N3CCOCC3)cc1)nn2-c1c(F)cccc1F>>Cl.O=c1[nH]cc(Cl)c2c1c(-c1ccc(N3CCOCC3)cc1)nn2-c1c(F)cccc1F,,CCO,,,,val
US04125729,COC(=O)C(Br)c1ccc(Oc2ccccc2)cc1.Oc1ccc(Cl)cc1>>COC(=O)C(Oc1ccc(Cl)cc1)c1ccc(Oc2ccccc2)cc1,,CO,,,,val
US20080280872A1,CNC.COC[C@H](C)Oc1cc(Oc2ccc(C(=O)O)cc2)cc(C(=O)Nc2cc[nH]n2)c1>>COC[C@H](C)Oc1cc(Oc2ccc(C(=O)N(C)C)cc2)cc(C(=O)Nc2cc[nH]n2)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110034440A1,CC(C)(C)OC(=O)NCCN(CC(F)(F)F)C(=O)C(F)(F)F.Cl>>Cl.NCCN(CC(F)(F)F)C(=O)C(F)(F)F,,CCOC(C)=O,,,,val
US04593033,COC(=O)/C=C(/C)N.COC(=O)CC(C)=O.O=Cc1cc(Cl)ccc1COCc1ccccc1>>COC(=O)C1=C(C)NC(C)C(C(=O)OC)=C1c1cc(Cl)ccc1COCc1ccccc1,,CC(C)O,,,,val
US20110039840A1,NOC1CCCCO1.Nc1ccc(CCN2CCC3(CC2)CC(=O)c2cc(/C=C/C(=O)O)ccc2O3)cc1>>Nc1ccc(CCN2CCC3(CC2)CC(=O)c2cc(/C=C/C(=O)NOC4CCCCO4)ccc2O3)cc1,,ClCCl,,,,val
US20100010035A1,COCCOCN(c1noc(C)c1C)S(=O)(=O)c1sc(C)cc1-c1ccc(CO)cc1.CS(=O)(=O)Cl>>COCCOCN(c1noc(C)c1C)S(=O)(=O)c1sc(C)cc1-c1ccc(S(C)(=O)=O)cc1C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130150343A1,CN(C)C1(C(=O)O)CCCC1.NNc1ccc(F)cn1>>CN(C)C1(C(=O)NNc2ccc(F)cn2)CCCC1,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20030027807A1,CCOC(=O)CCCN1CCn2nc(C(=O)OCc3ccccc3)cc2C1=O>>CCOC(=O)CCCN1CCn2nc(C(=O)O)cc2C1=O,[Pd],CCO,,CO,ClCCl,val
US20010011143A1,O=S(=O)(Oc1ccc(F)cc1)c1ccc(Oc2ccc(F)cc2)cc1>>O=S(=O)(O)c1ccc(Oc2ccc(F)cc2)cc1,,CCO,,[Na+].[OH-],,val
US20100137299A1,CCOC(=O)c1cccnc1CBr.O=C1Nc2ccccc2C12COc1cc3c(cc12)OCCO3>>CCOC(=O)c1cccnc1CN1C(=O)C2(COc3cc4c(cc32)OCCO4)c2ccccc21,,CN(C)C=O,,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20090069340A1,CCOC(=O)C(CC)C(C)=O.NNc1ccccc1>>CCc1c(C)[nH]n(-c2ccccc2)c1=O,,Cc1ccccc1,,,,val
US05342846,Cc1c(F)c(F)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1.c1cn(C2CCNCC2)nn1>>Cc1c(F)c(N2CCC(n3ccnn3)CC2)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1,,CC#N,,C1CCC2=NCCCN2CC1,Cl,val
US20130035292A1,CC(=O)OC(C)=O.CC(O)C(NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1>>CC(=O)OC(C)C(NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US04623649,CCOC(=O)c1ncc2[nH]c3ccc(C4CC=CCC4)cc3c2c1C>>CCOC(=O)c1ncc2[nH]c3ccc(C4CCCCC4)cc3c2c1C,[Ni],CCO,,,,val
US20120022044A1,Clc1ccncn1.O=C1C(n2cc(C3CCNCC3)nn2)CCc2c(F)cccc2N1CC(F)(F)F>>O=C1C(n2cc(C3CCN(c4ccncn4)CC3)nn2)CCc2c(F)cccc2N1CC(F)(F)F,,CC(C)O,,CCN(C(C)C)C(C)C,Cl,val
US08653089B2,Fc1ccc2nc([C@H](COCc3ccccc3)Nc3ncnc4nc[nH]c34)n(-c3ccccn3)c2c1>>OC[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2n1-c1ccccn1,,ClCCl,,BrB(Br)Br,CO,val
US20140256756A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.CS(=O)(=O)c1cc(F)c(O[C@H]2CCN(C3CCN(C(=O)CNC(=O)C(F)(F)F)CC3)C2=O)cc1F>>CS(=O)(=O)c1cc(F)c(O[C@H]2CCN(C3CCN(c4cnc(C(F)(F)F)s4)CC3)C2=O)cc1F,,Cc1ccccc1,O,,,val
US20120264749A1,C#CCOC.COC(=O)c1ccc(Br)c(F)c1>>COCC#Cc1ccc(C(=O)OC)cc1F,[Cu]I,CCOC(C)=O,,CCN(CC)CC,CN(C)C=O,val
US20140235628A1,CC(C)(C)OC(=O)N1CCC(/C=C/c2ccc3c(c2F)COC3=O)CC1>>CC(C)(C)OC(=O)N1CCC(CCc2ccc3c(c2F)COC3=O)CC1,[Pd],CCO,,CC(=O)O,,val
US20070185165A1,CC(C)[Si](OCc1nonc1C(=S)Nc1ccc(F)c(Cl)c1)(C(C)C)C(C)C.COS(=O)(=O)C(F)(F)F>>CSC(=Nc1ccc(F)c(Cl)c1)c1nonc1CO[Si](C(C)C)(C(C)C)C(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140206700A1,C[C@@H](O)CC(=O)O.Cn1nc(C2CCNCC2)nc1-c1cnc(N)c(-c2nnc(C(C)(C)C)o2)n1>>C[C@@H](O)CC(=O)N1CCC(c2nc(-c3cnc(N)c(-c4nnc(C(C)(C)C)o4)n3)n(C)n2)CC1,,CC#N,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20080108648A1,COc1cc(C(=O)c2nc(Br)c3ccccn23)ccc1[N+](=O)[O-].COc1ccc(B(O)O)cc1>>COc1ccc(-c2nc(C(=O)c3ccc([N+](=O)[O-])c(OC)c3)n3ccccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US04126624,CC(=O)c1occc1Br>>CC(O)c1occc1Br,,CCO,,,,val
US20080171772A1,CC(C)c1cc2ccc([N+](=O)[O-])cc2[nH]1.CN(C)C=O>>CC(C)c1[nH]c2cc([N+](=O)[O-])ccc2c1C=O,,CCOC(C)=O,,O=P(Cl)(Cl)Cl,,val
US20160168156A1,O=C([O-])c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12>>O=C(O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12,,CCO,O,[Li+].[OH-],,val
US20130225554A1,CC(C)(C)OC(=O)NCCONC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)OC(=O)N1CC[C@H](ONC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3O)C1,,ClCCl,,,,val
US20090131461A1,CC(C)(C)OC(=O)Nc1ccc(NC(=O)c2ccccc2)cc1>>Nc1ccc(NC(=O)c2ccccc2)cc1,,ClCCl,O,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20090239854A1,C=Cc1cncnc1.CN1CCc2[nH]c3ccc(Cl)cc3c2C1>>CN1CCc2c(c3cc(Cl)ccc3n2CCc2cncnc2)C1,,CN1CCCC1=O,O,[K+].[OH-],,val
US20050014750A1,C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1.N#Cc1ccc2c(c1)CCOC2CC=O>>C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CCC1OCCc2cc(C#N)ccc21,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20110086882A1,C1COCCO1.CC[Zn]CC.COCc1cc(OC)c(-c2c(Br)sc3c(NC(=O)OC(C)(C)C)c(OC)nn23)c(OC)c1>>CCc1sc2c(NC(=O)OC(C)(C)C)c(COC)nn2c1-c1c(OC)cc(COC)cc1OC,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,CCCCCCC,CCOC(C)=O,,,val
US20040072770A1,COc1ccc(-c2ccnc(NCc3ccc(C(=O)O)cc3)n2)cc1OC.Nc1ccccc1N>>COc1ccc(-c2ccnc(NCc3ccc(C(=O)Nc4ccccc4N)cc3)n2)cc1OC,,CN(C)C=O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US05650422,COCCOCCOc1ccc2c(c1)S(=O)(=O)N(CSc1ccccc1)C2=O.O=S(=O)(Cl)Cl>>COCCOCCOc1ccc2c(c1)S(=O)(=O)N(CCl)C2=O,,ClCCl,,CCCCCC,,val
US20020026060A1,CCCCCC(CO)c1ccc2c(c1)C(C)(C)CCS2.COC(=O)c1ccc(O)cc1>>CCCCCC(COc1ccc(C(=O)OC)cc1)c1ccc2c(c1)C(C)(C)CCS2,,C1CCOC1,CCOCC,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070027199A1,COc1ccc(CCl)c(C)c1C.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c(C)c1C.[Cl-],,CCCCCC,Cc1ccccc1,,,val
US07144885B2,COc1cccc(C(=O)CBr)c1.N#Cc1cc2c(cc1O)OCCC2>>COc1cccc(C(=O)c2oc3cc4c(cc3c2N)CCCO4)c1,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20140094474A1,CCOC(=O)c1cc(-c2cn(Cc3ccccc3)cn2)n[nH]1>>CCOC(=O)c1cc(-c2c[nH]cn2)n[nH]1,[Pd],CC(=O)O,CCO,[H][H],,val
US20070072888A1,CN(C)CCN.CN1CN(c2ccccc2)C2(CCN(C(=O)c3cn(CC(=O)O)c4cc(Cl)ccc34)CC2)C1=O>>CN(C)CCNC(=O)Cn1cc(C(=O)N2CCC3(CC2)C(=O)N(C)CN3c2ccccc2)c2ccc(Cl)cc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04987132,CC(C)(CCN1CCN(C(=O)C2CSC(c3cccnc3)N2)CC1)c1ccccc1.O=C(O)/C=C/C(=O)O>>CC(C)(CCN1CCN(C(=O)C2CSC(c3cccnc3)N2)CC1)c1ccccc1.O=C(O)/C=C/C(=O)O,,CCO,,,,val
US20080233127A1,CC1(C)OB(c2cncc(C=O)c2)OC1(C)C.Clc1nc(N2CCOCC2)c2ncn(C3CCN(Cc4ccccc4)CC3)c2n1>>O=Cc1cncc(-c2nc(N3CCOCC3)c3ncn(C4CCN(Cc5ccccc5)CC4)c3n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20140275179A1,C=CC(=O)OCC.Oc1ccc(Br)c(C(F)(F)F)c1>>CCOC(=O)/C=C/c1ccc(O)cc1C(F)(F)F,Cl[Pd]Cl,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20150031685A1,CN(C(=O)OCc1ccccc1)[C@H](CN1CC[C@H](O[Si](C)(C)C(C)(C)C)C1)c1cccc(-c2nccs2)c1>>CN[C@H](CN1CC[C@H](O)C1)c1cccc(-c2nccs2)c1,,CO,Cl,,,val
US20150246911A1,CNc1ncc(SC(F)(F)F)cc1N.O=CO>>Cn1cnc2cc(SC(F)(F)F)cnc21,,O,,,,val
US20090281103A1,COCCCc1cc(CN(C(=O)C(CNC(=O)OC(C)(C)C)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)cc(OCCN2CCCC2)c1>>COCCCc1cc(CN(C(=O)C(CN)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)cc(OCCN2CCCC2)c1,,ClCCl,,Cl,,val
US20040152893A1,CCN(CC)C(=O)CCc1cc(N)ccc1Cl>>CCN(CC)CCCc1cc(N)ccc1Cl,,C1CCOC1,,B,Cl,val
US20100256092A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc3c(c2)B(O)OC3)CC1>>OB1OCc2ccc(OC3CCNCC3)cc21,,CO,,CCOCC,Cl,val
US20060142247A1,CCN1C(=O)C(C)(C)c2cc3nc(-c4n[nH]c5ccc(C(=O)O)cc45)[nH]c3cc21.Nc1ccccc1>>CCN1C(=O)C(C)(C)c2cc3nc(-c4n[nH]c5ccc(C(=O)Nc6ccccc6)cc45)[nH]c3cc21,,C1CCOC1,CN(C)C=O,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20150133510A1,Cc1ccc(NC(=O)Nc2ccc(CN(Cc3ccccc3)Cc3ccc(NC(=O)Nc4ccc(C)cc4)cc3)cc2)cc1.Cl>>Cc1ccc(NC(=O)Nc2ccc(C[NH+](Cc3ccccc3)Cc3ccc(NC(=O)Nc4ccc(C)cc4)cc3)cc2)cc1.[Cl-],,CCOCC,,,,val
US04686213,CCC1(CC(=O)OC)OCC(Cc2ccccc2)c2c1[nH]c1ccccc21>>CCC1(CC(=O)O)OCC(Cc2ccccc2)c2c1[nH]c1ccccc21,,CCO,,[Na+].[OH-],,val
US20060106013A1,C1COCCN1.CC(=O)Nc1nc2c(s1)-c1c(cnn1-c1ccc(C(=O)O)cc1)CC2>>CC(=O)Nc1nc2c(s1)-c1c(cnn1-c1ccc(C(=O)N3CCOCC3)cc1)CC2,,CN(C)C=O,,CCN(CC)CC,,val
US20150246934A1,CCOP(=O)(O)O[C@H](C)c1ncc(Oc2nc(N3C[C@H]4C[C@@H]3C[C@H]4NC(=O)OC(C)(C)C)c3c(n2)[nH]c2c(N(C)C(=O)OC(C)(C)C)cc(F)cc23)cn1>>CCOP(=O)(O)O[C@H](C)c1ncc(Oc2nc(N3C[C@H]4C[C@@H]3C[C@H]4N)c3c(n2)[nH]c2c(NC)cc(F)cc23)cn1,,O=C(O)C(F)(F)F,,,,val
US20150191472A1,COc1ncnc2c([C@H]3[C@@H]4OC(C)(C)O[C@@H]4[C@@H](CO[Si](C)(C)C(C)(C)C)N3C(=O)OC(C)(C)C)c[nH]c12.Cl>>Cl.O=c1[nH]cnc2c([C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)c[nH]c12,,CO,,,,val
US20140275172A1,C#CCBr.COC(=O)c1cccc(O)c1>>C#CCOc1cccc(C(=O)OC)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120122780A1,CCOC(=O)C(C)(C)Oc1ccnn1-c1cccc2ccccc12>>CC(C)(Oc1ccnn1-c1cccc2ccccc12)C(=O)O,,CO,,[Na+].[OH-],,val
US04762835,O=Cc1c(F)c(F)c(Br)c(F)c1F>>OCc1c(F)c(F)c(Br)c(F)c1F,,CO,,O,[BH4-].[Na+],val
US04673682,Brc1cnc(-c2ccccc2)c2ccccc12.N#C[Cu]C#N>>N#Cc1cnc(-c2ccccc2)c2ccccc12,,CN(C)C=O,,,,val
US20090291978A1,CC(C)(C)OC(=O)NCC1CCC(CN[C@H](C(=O)OC2CCCC2)c2ccccc2)CC1>>NCC1CCC(CN[C@H](C(=O)OC2CCCC2)c2ccccc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05122523,O=C/C=C\COCc1ccccc1>>OC/C=C/COCc1ccccc1,,CCO,,[BH4-].[Na+],,val
US20020082426A1,CC(C)(C)OC(=O)N1CC(O)C(OCc2ccccc2)C1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.OC1CNCC1OCc1ccccc1,,ClCCl,,,,val
US20110124618A1,C1CCNC1.CCOC(=O)c1cc(-c2cccc(OCCCCl)c2)n(-c2cccc(Cl)c2)n1>>CCOC(=O)c1cc(-c2cccc(OCCCN3CCCC3)c2)n(-c2cccc(Cl)c2)n1,,CCO,,,,val
US20140057915A1,CC(C)C(=O)CC#N.Cc1ccc(NN)cc1C>>Cc1ccc(-n2nc(C(C)C)cc2N)cc1C,,CCO,,Cl,Cl,val
US20120238540A1,CC#N.N#Cc1cc(-c2ccnc(Nc3ccc(C=O)cc3)n2)ccc1OC1CCOCC1.N#Cc1cc(-c2ccnc(Nc3ccc(CO)cc3)n2)ccc1OC1CCOCC1>>COCCNCc1ccc(Nc2nccc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)cc1,O=[Mn]=O,,,,,val
US20140031360A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Fc1cccc(F)c1-c1ccc2[nH]cc(I)c2c1>>CC(C)(C)OC(=O)n1cc(I)c2cc(-c3c(F)cccc3F)ccc21,,CN(C)C=O,ClCCl,CC(C)(C)[O-].[K+],,val
US20060122064A1,C#CCBr.CCOC(=O)CCc1cc(F)c(O)c(OC)c1>>C#CCOc1c(F)cc(CCC(=O)O)cc1OC,,CCOC(C)=O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20030119836A1,CS(=O)(=O)c1ccc(NN)nc1.CSC(SC)=C(C#N)C(=O)c1ccccc1>>CSc1nn(-c2ccc(S(C)(=O)=O)cn2)c(-c2ccccc2)c1C#N,,CCO,O,,,val
US20090258877A1,Clc1ccc(-c2nc(Cl)c3nncn3n2)c(Cl)c1.N#Cc1ccc(NC2CCCNC2)nc1>>N#Cc1ccc(NC2CCCN(c3nc(-c4ccc(Cl)cc4Cl)nn4cnnc34)C2)nc1,,CS(C)=O,,CCN(C(C)C)C(C)C,Cl,val
US05364875,CCOC(=O)CCCCn1c(C(C)C)nc2ccccc21>>CC(C)c1nc2ccccc2n1CCCCCO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150105396A1,CC1(N=CNc2c(Cl)cnnc2Cl)CC1>>CC1(n2cnc3c(Cl)cnnc32)CC1,[Cu]Br,CN(C)C=O,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US06417183B1,CC(C)=O.c1ccc2c(c1)CCCC2N1CCCNCC1>>CC(C)N1CCCN(C2CCCc3ccccc32)CC1,,C1CCOC1,CO,CC(=O)O,[BH3-]C#N.[Na+],val
US20070088041A1,COc1nnc(-c2ccncc2)cc1-c1cc2ccc(C(C)O)cc2n1C(=O)OC(C)(C)C>>COc1nnc(-c2ccncc2)cc1-c1cc2ccc(C(C)=O)cc2n1C(=O)OC(C)(C)C,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20100292225A1,CC(C)S(=O)(=O)NC(c1cncc(Br)c1)C1CC1.CC1(C)OB(c2ccc(C#N)c(Cl)c2)OC1(C)C>>CC(C)S(=O)(=O)NC(c1cncc(-c2ccc(C#N)c(Cl)c2)c1)C1CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20120237591A1,CC(C)(C)[Si](C)(C)Cl.CN(C)CC(O)CO>>CN(C)CC(O)CO[Si](C)(C)C(C)(C)C,,ClCCl,,O,c1c[nH]cn1,val
US20040162303A1,C1CCNC1.COc1ccc(F)cc1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCCl)CC2)nc1N>>COc1ccc(F)cc1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCN3CCCC3)CC2)nc1N,,C1COCCO1,,[I-].[K+],,val
US20050197346A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(NCCBr)c1ccc(C(F)(F)F)cc1>>CC(C)(C)OC(=O)N1CCN(CCNC(=O)c2ccc(C(F)(F)F)cc2)CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040209948A1,Nc1cccc2c(S(=O)(=O)O)cccc12.O=C(Cl)c1ccccc1>>O=C(Nc1cccc2c(S(=O)(=O)O)cccc12)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20150210630A1,BrCC1CC1.O=C1c2ccccc2C(=O)N1CC(=NO)c1ncc(C(F)(F)F)cc1Cl>>O=C1c2ccccc2C(=O)N1C/C(=N\OCC1CC1)c1ncc(C(F)(F)F)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100305096A1,CC(=O)OC(C)(C)C(=O)Cl.CC(C)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CNC3)n(C)c2n1>>CC(=O)OC(C)(C)C(=O)N1CC(Cc2nc3c(N4CCOCC4)nc(-n4c(C)nc5ccccc54)nc3n2C)C1,,C1CCOC1,,CCN(CC)CC,,val
US20040132727A1,CC(O)c1cccc(N(C)C)c1.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)OC(C)c4cccc(N(C)C)c4)c(C)c3C)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US20030220350A1,CC(C)(C)c1ccc(N(Cc2ccc(C(=O)Nc3nn[nH]n3)cc2)C(=O)Nc2cccc(C(=O)O)c2)cc1.O=C(Oc1c(F)c(F)c(F)c(F)c1F)C(F)(F)F>>CC(C)(C)c1ccc(N(Cc2ccc(C(=O)Nc3nn[nH]n3)cc2)C(=O)Nc2cccc(C(=O)Oc3c(F)c(F)c(F)c(F)c3F)c2)cc1,,CN(C)C=O,,c1ccncc1,,val
US03931176,CCC(O)CNN.O=C(O)[C@@H]1CC[C@H]1C(=O)c1ccc(Cl)cc1>>CCC(O)CN1N=C(c2ccc(Cl)cc2)C2CCC2C1=O,,O,,Cc1ccccc1,,val
US20100093757A1,COC(=O)[C@@H](O)COCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.Cc1ccc(C)c(-n2ncc3c(Cl)ncnc32)c1>>COC(=O)[C@H](COCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)Oc1ncnc2c1cnn2-c1cc(C)ccc1C,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20160024110A1,C=CCOC(=O)CC(=O)CCl.COC(OC)OC>>C=CCOC(=O)/C=C(\CCl)OC,O=S(=O)(O)O,ClC(Cl)Cl,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20160159774A1,NO.O=C1CCCc2cc(Br)ccc21>>O/N=C1\CCCc2cc(Br)ccc21,,CCO,,O,CC(=O)[O-].[Na+],val
US20160002205A1,CC(C)(C)OC(=O)N1CCC(n2cc(-c3cnc(N)c(CO)c3)cn2)CC1.Oc1cccc(F)c1>>CC(C)(C)OC(=O)N1CCC(n2cc(-c3cnc(N)c(COc4cccc(F)c4)c3)cn2)CC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090069300A1,N#Cc1ccc(Cl)nc1.O=C1NCCc2cc(O)ccc21>>N#Cc1ccc(Oc2ccc3c(c2)CCNC3=O)nc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120083469A1,CC(C)(C)OC(=O)C(CCCCB1OC(C)(C)C(C)(C)O1)(N=C(c1ccccc1)c1ccccc1)C(=O)c1ccccc1>>NC(CCCCB(O)O)C(=O)c1ccccc1,,Cl,O,,,val
US20060281799A1,CC(C)(C)OC(=O)NC1CCc2cccc(Nc3ncc(-c4ccc(C(F)(F)F)cc4F)o3)c2C1>>NC1CCc2cccc(Nc3ncc(-c4ccc(C(F)(F)F)cc4F)o3)c2C1,,ClCCl,,C[Si](C)(C)I,,val
US20160200719A1,Brc1ccc2nncc(N3CCN(Cc4ccccc4)CC3)c2c1.O=C(c1ccc(Cl)cc1)c1ccc(Cl)cc1>>OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc2nncc(N3CCN(Cc4ccccc4)CC3)c2c1,,C1CCOC1,,[Li]CCCC,,val
US05807873,Cc1ccc(/C(=C(/CO)CCO)c2ccc(S(=O)(=O)NC(C)(C)C)cc2)cc1F>>Cc1ccc(/C(=C2\CCOC2)c2ccc(S(N)(=O)=O)cc2)cc1F,,O=C(O)C(F)(F)F,,,,val
US20110152318A1,CS(=O)(=O)Nc1c(F)cc(CNC(=O)c2ccc(Br)s2)cc1F.OB(O)c1ccc(C(F)(F)F)cc1>>CS(=O)(=O)Nc1c(F)cc(CNC(=O)c2ccc(-c3ccc(C(F)(F)F)cc3)s2)cc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,Cc1ccccc1,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20140323464A1,CC(C)(C)OC(=O)N1CCCC(Nc2nc(Nc3ccccc3)ncc2F)C1>>Fc1cnc(Nc2ccccc2)nc1NC1CCCNC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05399580,BrCc1ccccc1.CC(=O)OC[C@@H]1C[C@H](n2c(=S)[nH]c3cc(Cl)c(Cl)cc32)[C@@H](OC(C)=O)[C@H]1OC(C)=O>>OC[C@@H]1C[C@H](n2c(SCc3ccccc3)nc3cc(Cl)c(Cl)cc32)[C@@H](O)[C@H]1O,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US06627651B1,CCOCCOc1ccccc1COc1ccc2c(c1)C=C(C(=O)OC)CCS2(=O)=O>>CCOCCOc1ccccc1COc1ccc2c(c1)C=C(C(=O)O)CCS2(=O)=O,,C1CCOC1,CO,O=C([O-])[O-].[K+].[K+],,val
US20110028469A1,COC(=O)c1sccc1N.Cc1ccc(S(=O)(=O)Cl)c(C)c1>>COC(=O)c1sccc1NS(=O)(=O)c1ccc(C)cc1C,,ClCCl,,c1ccncc1,,val
US05208228,CC1CO1.CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(N)C(OC)C3)C(C)CCC1=O)C(C)CC2OC>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(NCC(C)O)C(O)C3)C(C)CCC1=O)C(C)CC2OC,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060223826A1,CCOc1ccc(CCl)cc1[N+](=O)[O-].CNC>>CCOc1ccc(CN(C)C)cc1[N+](=O)[O-],,C1CCOC1,,,,val
US20100113796A1,CCOC(=O)CCn1cc(Cl)c2cc(C(=N)NO)ccc21.COc1ccc(C(=O)O)cc1Br>>CCOC(=O)CCn1cc(Cl)c2cc(-c3noc(-c4ccc(OC)c(Br)c4)n3)ccc21,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20050137193A1,CC1(c2ccccc2)CCOCC1.O=S(=O)(O)Cl>>CC1(c2ccc(S(=O)(=O)Cl)cc2)CCOCC1,,ClCCl,,,,val
US20040102636A1,Cc1ccc(Oc2ccc([N+](=O)[O-])cc2)cn1>>Cc1ccc(Oc2ccc(N)cc2)cn1,[Pd],CCOC(C)=O,,,,val
US20080249130A1,CC(C)(C)c1csc(Br)n1.COC(=O)c1ccccc1B(O)O>>COC(=O)c1ccccc1-c1nc(C(C)(C)C)cs1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US06350749B1,Cc1cn(C)c2c1C(=O)CC(c1ccccc1)C2.Cl.N=C(N)NN>>Cc1cn(C)c2c1C(=NNC(=N)N)CC(c1ccccc1)C2.Cl,,CCO,,Cl,O,val
US04352795,CSc1nc(Cl)c2cc[nH]c2n1.Cl[C@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1>>CSc1nc(Cl)c2ccn([C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc4ccccc4)[C@@H]3OCc3ccccc3)c2n1,,CN(C)C=O,,[H-].[Na+],,val
US20030069297A1,Cc1[nH]c(C=O)c(C)c1C(=O)NCCn1ccnn1.O=C1Cc2c(cccc2-c2cccc(Br)c2)N1>>Cc1[nH]c(C=C2C(=O)Nc3cccc(-c4cccc(Br)c4)c32)c(C)c1C(=O)NCCn1ccnn1,C1CCNCC1,CCO,,,,val
US20160222014A1,CCC1CN(c2ccc([N+](=O)[O-])cc2)CCN1C(=O)OC(C)(C)C>>CCC1CN(c2ccc(N)cc2)CCN1C(=O)OC(C)(C)C,[Pd],CO,,,,val
US20150307451A1,COC(=O)c1cc(Cc2ccc(-n3cccn3)cc2)c(C)cc1C=O.NC1CCOCC1>>Cc1cc2c(cc1Cc1ccc(-n3cccn3)cc1)C(=O)N(C1CCOCC1)C2,,C1CCOC1,,O=S(=O)([O-])[O-].[Mg+2],,val
US04880775,CC1OC(C)OC(C)O1.Cc1c(C(C)(C)C)cc(C(C)C)c(O)c1CO>>Cc1c(C(C)(C)C)cc(C(C)C)c2c1COC(C)O2,,C1COCCO1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20130267546A1,C=O.CCCCCc1nc(N)nc(C)c1OCc1ccccc1.CO>>CCCCCc1nc(N(C)C)nc(C)c1OCc1ccccc1,,CO,,[BH3-]C#N.[Na+],,val
US20060281666A1,COc1ccc(-c2cc(C(=O)N[C@H]3CCCCN(C(=O)OC(C)(C)C)C3)c(NC(N)=O)s2)cc1>>COc1ccc(-c2cc(C(=O)N[C@H]3CCCCNC3)c(NC(N)=O)s2)cc1,,C1COCCO1,,Cl,,val
US20120142966A1,C#CCN[C@@H]1CCc2ccccc21.N[C@@H](CC(=O)O)C(=O)O>>C#CCN[C@@H]1CCc2ccccc21.N[C@@H](CC(=O)[O-])C(=O)[O-],,CC(C)O,O,,,val
US05292732,C=O.NCCn1cccc1-c1ccccc1.O=C(O)/C=C/C(=O)O>>O=C(O)/C=C/C(=O)O.c1ccc(-c2ccc3n2CCNC3)cc1,,CC(=O)O,CCO,,,val
US04987132,NO.O=Cc1ccc(OCCCc2ccccc2)cc1>>ON=Cc1ccc(OCCCc2ccccc2)cc1,,CO,,Cl,[Na+].[OH-],val
US20140303164A1,Cn1cnc(S(=O)(=O)Cl)c1.Cn1nc(N)c2cccc(-c3ccc(C#CC(C)(C)O)nc3[C@H](Cc3cc(F)cc(F)c3)NC(=O)Cn3nc(C(F)(F)F)c4c3C(F)(F)[C@@H]3C[C@H]43)c21>>Cn1cnc(S(=O)(=O)Nc2nn(C)c3c(-c4ccc(C#CC(C)(C)O)nc4[C@H](Cc4cc(F)cc(F)c4)NC(=O)Cn4nc(C(F)(F)F)c5c4C(F)(F)[C@@H]4C[C@H]54)cccc23)c1,,ClCCl,,c1ccncc1,,val
US20120136190A1,C=CC(C)C.CC(C)CCO>>CC(C)CCOCCC(C)C,,O,,,,val
US20050032786A1,N#Cc1ccccn1.O=C(O)c1ccc(C(=O)O)c(S)c1>>O=C(O)c1ccc2c(=O)nc(-c3ccccn3)sc2c1,,c1ccncc1,,,,val
US06462036B1,CCOC(=O)COc1cccc(-c2n[nH]c3c2Cc2ccccc2-3)c1>>O=C(O)COc1cccc(-c2n[nH]c3c2Cc2ccccc2-3)c1,,CCO,,[Na+].[OH-],,val
US20090186868A1,COc1ccc(N2C(=O)[C@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]2[C@H]2COC(C)(C)O2)cc1>>COc1ccc(N2C(=O)[C@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]2[C@H](O)CO)cc1,,C1CCOC1,O,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20080230743A1,N#CCCN(CCC#N)CCCCCCN(CCC#N)CCC#N>>NCCCN(CCCN)CCCCCCN(CCCN)CCCN,,C1COCCO1,,[H][H],,val
US05051524,Cl.NCCCP(=O)(O)c1ccccc1>>Cl.NCCCP(=O)(O)C1CCCCC1,,O,,[H][H],,val
US20100121052A1,NC(N)=O.Nc1c(Br)cc(C(F)(F)F)cc1C=O>>OC1=NC(O)c2cc(C(F)(F)F)cc(Br)c2N1,,O,,,,val
US06143751,N#Cc1cncc(Br)c1.OB(O)c1ccc(OC[C@H](O)CCc2cccnc2)cc1>>N#Cc1cncc(-c2ccc(OC[C@H](O)CCc3cccnc3)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20040072832A1,Cc1c(OCCCS(C)(=O)=O)cn2ncnc(Oc3ccccc3)c12>>Cc1c(OCCCS(C)(=O)=O)cn2ncnc(O)c12,,CCO,,Cl,,val
US20120214767A1,C=Cc1ccc2c(c1)CCc1c-2noc1-c1noc(CC(C)C)c1C(F)(F)F.O=[O+][O-]>>CC(C)Cc1onc(-c2onc3c2CCc2cc(C=O)ccc2-3)c1C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20040009979A1,CC(=O)Cl.C[C@@](O)(C(=O)O)C(F)(F)F.O=C(Cl)C(=O)Cl>>CC(=O)O[C@](C)(C(=O)Cl)C(F)(F)F,CN(C)C=O,Cc1ccccc1,ClCCl,,,val
US20130210831A1,CN[C@@H]1CCN(c2ncnc3c2ccn3COCC[Si](C)(C)C)C1.Cc1cc(Cl)ncc1[N+](=O)[O-]>>Cc1cc(N(C)[C@@H]2CCN(c3ncnc4c3ccn4COCC[Si](C)(C)C)C2)ncc1[N+](=O)[O-],,CN1CCCC1=O,,CCN(C(C)C)C(C)C,O,val
US20130184273A1,Cc1cn2cc(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)nc2n1>>Cc1cn2cc(-c3ccccc3)c(-c3ccc(C4(N)CCC4)cc3)nc2n1,,C1COCCO1,,Cl,,val
US05554607,CCOC(=O)CNc1ccccc1.Cc1c(Cl)cccc1N=C=S>>Cc1c(Cl)cccc1N1C(=O)CN(c2ccccc2)C1=S,,ClC(Cl)Cl,,,,val
US20040092556A1,CC(C)(C)OC(=O)N(Cc1ccccn1)Cc1ccc(C(=O)N[C@@H](CCCN[C@H]2CCCc3cccnc32)C(=O)NCc2cccc3ccccc23)c2ccccc12.Cl>>Cl.O=C(N[C@@H](CCCN[C@H]1CCCc2cccnc21)C(=O)NCc1cccc2ccccc12)c1ccc(CNCc2ccccn2)c2ccccc12,,CO,,C1COCCO1,,val
US06825191B2,CNC.O=C(O)C(F)(F)F.O=C(O)c1ccc2c(c1)N(Cc1ccc(OC3CCNCC3)cc1)C(=O)CN(C(=O)c1ccc(Cl)cc1)C2>>CN(C)C(=O)c1ccc2c(c1)N(Cc1ccc(OC3CCNCC3)cc1)C(=O)CN(C(=O)c1ccc(Cl)cc1)C2.O=C(O)C(F)(F)F,,ClCCl,,CCN(CC)CC,Cl,val
US20080076803A1,CCCCCCCCn1sccc1=O>>CCCCCCCCN1CC=CS1=O,,CO,,[Na+].[OH-],,val
US20150031685A1,CN(C(=O)OCc1ccccc1)[C@H](CN1CC[C@H](O[Si](C)(C)C(C)(C)C)C1)c1cccc(-c2nccn2CC2CC2)c1>>CN[C@H](CN1CC[C@H](O)C1)c1cccc(-c2nccn2CC2CC2)c1,,Cl,,,,val
US20120245176A1,C1CNCCN1.O=[N+]([O-])c1cnc(Cl)c(Cl)c1>>O=[N+]([O-])c1cnc(N2CCNCC2)c(Cl)c1,,CN(C)C=O,,O,,val
US20130150342A1,CC(C)(C#N)c1ccc(Nc2nc(Cl)ncc2C#CCO)cc1>>CC(C)(C#N)c1ccc(-n2c(CO)cc3cnc(Cl)nc32)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100152216A1,CC(C)I.CC1(c2ccccc2)NC(=O)NC1=O>>CC(C)N1C(=O)NC(C)(c2ccccc2)C1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060128814A1,COc1cc(C(C)=O)ccc1OCC(=O)OC(C)(C)C.O=[N+]([O-])O>>COc1cc(C(C)=O)c([N+](=O)[O-])cc1OCC(=O)O,,CC(=O)OC(C)=O,,,,val
US04591548,CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)N1C(=O)COc2cc(N)c(O)cc21.O=C=Nc1ccc(C(F)(F)F)cc1>>CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)N1C(=O)COc2cc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c(O)cc21,,C1CCOC1,,,,val
US05840732,Cc1cccc2nccn12.ClCCCCBr>>ClCCCCCc1cccc2nccn12,,C1CCOC1,,O,CC(C)[N-]C(C)C.[Li+],val
US20090088425A1,COc1ccc(C(C)C(O)(c2cnc3ccccc3c2)C(F)(F)F)c(Cl)c1>>CC(c1ccc(O)cc1Cl)C(O)(c1cnc2ccccc2c1)C(F)(F)F,,Br,,O=C([O-])[O-].[Na+].[Na+],,val
US20070185103A1,CI.COC(=O)c1c[nH]c(=O)c(Br)c1>>COC(=O)c1cc(Br)c(=O)n(C)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)O)c2)=C(C)C1=O.Nc1ccc(S(=O)(=O)C(F)(F)F)cc1>>COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)c2)=C(C)C1=O,,ClCCl,,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US20130190249A1,O=[N+]([O-])c1cccc(OCCO)c1>>Nc1cccc(OCCO)c1,[Fe],CCO,,[Cl-].[NH4+],,val
US20150126498A1,COc1cc(N)cnc1CNC(=O)OC(C)(C)C.O=S(=O)(Cl)c1cccnc1Cl>>COc1cc(NS(=O)(=O)c2cccnc2Cl)cnc1CNC(=O)OC(C)(C)C,,ClCCl,,c1ccncc1,,val
US20050261277A1,CS(=O)(=O)Oc1ccc2c(C(=O)c3ccc(OCCN4CCCCC4)cc3)c(OS(=O)(=O)C(F)(F)F)ccc2c1.OB1OCc2cc(F)ccc21>>CS(=O)(=O)Oc1ccc2c(C(=O)c3ccc(OCCN4CCCCC4)cc3)c(-c3ccc(F)cc3CO)ccc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20060211697A1,Cc1ccc(Oc2ccccc2NN)c(O)c1.c1ncncn1>>Cc1ccc(Oc2ccccc2-n2cncn2)c(O)c1,,CCO,,,,val
US05440044,CCCCCCCCC(O)/C=C/c1cccc(OCC(=O)OC)n1>>CCCCCCCCC(O)/C=C/c1cccc(OCC(=O)O)n1,,CO,,[Na+].[OH-],,val
US05045552,Cc1c(OCCN2C(=O)CCC2=O)ccnc1CCl.Sc1nc2ccccc2[nH]1>>Cc1c(OCCN2C(=O)CCC2=O)ccnc1CSc1nc2ccccc2[nH]1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040082475A1,Cn1nc(C(F)(F)F)cc1Oc1cccc(F)n1.FC(F)(F)c1cn[nH]c1>>Cn1nc(C(F)(F)F)cc1Oc1cccc(-n2cc(C(F)(F)F)cn2)n1,,CC(=O)N(C)C,,O,[H-].[Na+],val
US20130096120A1,BrCC12CC3CC(CC(C3)C1)C2.O=c1ccc(Br)c[nH]1>>O=c1ccc(Br)cn1CC12CC3CC(CC(C3)C1)C2,,CN(C)C=O,,[H-].[Na+],,val
US20130225646A1,CS(=O)(=O)Cl.NC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1C(F)(F)F>>CS(=O)(=O)NC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1C(F)(F)F,,c1ccncc1,,Cl,,val
US20100113528A1,NC(=O)c1ccc(C2=CCCCC2)c(C(F)(F)F)c1>>NC(=O)c1ccc(C2CCCCC2)c(C(F)(F)F)c1,[Pd],CO,,,,val
US20100298384A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC[C@H]1CN(c2ccc(C(N)=O)c(F)c2)C(=O)O1>>CC(C)(C)OC(=O)NC[C@H]1CN(c2ccc(C(N)=O)c(F)c2)C(=O)O1,,C1CCOC1,CO,CCN(CC)CC,,val
US20130150407A1,COC(=O)Cc1cc2ccc(F)cc2c(C2CCN(S(=O)(=O)N3CCCC3)CC2)c1C>>Cc1c(CC(=O)O)cc2ccc(F)cc2c1C1CCN(S(=O)(=O)N2CCCC2)CC1,,C1CCOC1,O,[Li+].[OH-],,val
US20140066424A1,BrC1COC1.Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1cccc(O)c1>>Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1cccc(OC2COC2)c1,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20100130468A1,COC(=O)c1cc(Br)cc2c(C3CCS(=O)(=O)C3)cn(C(=O)OC(C)(C)C)c12>>O=C(O)c1cc(Br)cc2c(C3CCS(=O)(=O)C3)c[nH]c12,,O,,CO,[Li+].[OH-],val
US20110251186A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.COc1ccc2c(c1)[C@@]1(COCC(=O)N1)c1cc(Br)cc(F)c1O2>>COc1ccc2c(c1)[C@@]1(COCC(=S)N1)c1cc(Br)cc(F)c1O2,,Cc1ccccc1,,,,val
US20130137865A1,Cn1ncc(C=O)c1Cl.OCc1ccc(C(F)(F)F)cc1>>Cn1ncc(C=O)c1OCc1ccc(C(F)(F)F)cc1,,ClC(Cl)Cl,,C1CCOC1,CC(C)(C)[O-].[K+],val
US06043248,BrCc1ccccc1.Oc1ccc(I)nc1Cl>>Clc1nc(I)ccc1OCc1ccccc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20110118231A1,CC(C)(C)OC(=O)N1C[C@H]2CCNc3ccccc3[C@@H]2C1.O=C1CCC(=O)N1Cl>>CC(C)(C)OC(=O)N1C[C@H]2CCNc3c(Cl)cccc3[C@@H]2C1,,CN(C)C=O,,,,val
US20140142307A1,BrCc1ccc2ccccc2c1.Clc1nc[nH]c1Cl>>Clc1ncn(Cc2ccc3ccccc3c2)c1Cl,,CC#N,,[K+].[OH-],,val
US20050038035A1,CS(=O)(=O)OCc1ncn(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1.O=C(Nc1ccc(N2CCNCC2)cc1)C1=C(c2ccc(C(F)(F)F)cc2)CCCC1>>O=C(Nc1ccc(N2CCN(Cc3ncn(C(c4ccccc4)(c4ccccc4)c4ccccc4)n3)CC2)cc1)C1=C(c2ccc(C(F)(F)F)cc2)CCCC1,,C1CCOC1,,CCN(CC)CC,O,val
US04159331,CN(C)S(=O)(=O)Cl.O=S(=O)(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCNCC1>>CN(C)S(=O)(=O)N1CCN(S(=O)(=O)c2ccc(Nc3ccnc4cc(C(F)(F)F)ccc34)cc2)CC1,,CN(C)C=O,,CCN(CC)CC,,val
US03962224,CCCCOP(=O)(CN=Cc1ccccc1)OCCCC.O=C(Cl)OCC(=O)c1ccc(Br)cc1>>CCCCOP(=O)(OCCCC)C(N=Cc1ccccc1)C(=O)OCC(=O)c1ccc(Br)cc1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20100261755A1,CCOC(=O)CC(=O)[C@@H]1CCN(C(=O)OC)[C@@H](c2cccc(C(F)(F)F)c2)C1.NO>>COC(=O)N1CC[C@@H](c2cc(=O)[nH]o2)C[C@@H]1c1cccc(C(F)(F)F)c1,,CO,O,Cl,[Na+].[OH-],val
US05208247,Cc1ccc(S(=O)(=O)Cl)cc1.NCc1ccccn1>>Cc1ccc(S(=O)(=O)NCc2ccccn2)cc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20100266509A1,CCOC(=O)COCc1cc2c(C(=O)NCC34CC5CC(CC(C5)C3)C4)cccn2n1>>O=C(O)COCc1cc2c(C(=O)NCC34CC5CC(CC(C5)C3)C4)cccn2n1,,CCO,,[K+].[OH-],,val
US20140171403A1,CC(C)(C)OC(=O)NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1>>NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1,,ClCCl,,C1COCCO1,Cl,val
US20080221136A1,CCCCNc1cc[nH]c1C(=O)OCC.CCOC(=O)N=C=S>>CCCCn1c(=O)[nH]c(=S)c2[nH]ccc21,,Cc1ccccc1,O,Cl,[K+].[OH-],val
US20030187002A1,COC(=O)Cc1cnc(NC(=O)OC(C)(C)C)s1.O=[Se]=O>>COC(=O)C(=O)c1cnc(NC(=O)OC(C)(C)C)s1,,C1COCCO1,,CO,ClCCl,val
US04140696,CC(=O)c1c(C)[nH]c(-c2ccccc2)c1N(C)C.ClCc1ccccc1Cl>>CC(=O)c1c(N(C)C)c(-c2ccccc2)n(Cc2ccccc2Cl)c1C,,CC(C)O,,,,val
US20100261708A1,FC(F)(F)c1ccc2oc(N3CCCNCC3)nc2c1.O=C(O)C1CCC(F)(F)CC1>>O=C(C1CCC(F)(F)CC1)N1CCCN(c2nc3cc(C(F)(F)F)ccc3o2)CC1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04090862,COCNC(=O)Oc1cccc(Cl)c1.O=S(Cl)Cl>>O=C(NCCl)Oc1cccc(Cl)c1,,ClC(Cl)(Cl)Cl,,,,val
US05760041,Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1.O=C(O)C#Cc1ccccc1>>O=C(C#Cc1ccccc1)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1,,C1CCOC1,c1ccncc1,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20050054645A1,COC(=O)C(C(=O)OC)C(OCc1ccccc1)=C(C)O.N=CN>>COC(=O)c1ncnc(O)c1OCc1ccccc1,,CO,,Cl,C[O-].[Na+],val
US20040077584A1,CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(C(=O)NCCNC(=O)NCc4ccc(C(=O)OCc5ccccc5)cc4)nc32)[C@H](O)[C@@H]1O>>CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(C(=O)NCCNC(=O)NCc4ccc(C(=O)O)cc4)nc32)[C@H](O)[C@@H]1O,[Pd],CCO,,,,val
US20150018341A1,CCC(=C(c1ccc(OC)cc1)c1ccc(OCCCl)cc1)c1ccc2oc(Cl)cc2c1.CN>>CC/C(=C(\c1ccc(OC)cc1)c1ccc(OCCNC)cc1)c1ccc2oc(Cl)cc2c1,,CO,,,,val
US20060122168A1,CC[C@H]1Oc2ccc(F)cc2NC(=O)[C@H]1N(Cc1ccccc1)Cc1ccccc1>>CC[C@H]1Oc2ccc(F)cc2NC(=O)[C@H]1N,[Pd],CO,,,,val
US20050131015A1,CC1(C)OCC(COS(C)(=O)=O)O1.NC1Cc2ccccc2NC1=O>>CC1(C)OCC(CN2C(=O)C(N)Cc3ccccc32)O1,,CN(C)C=O,,Cl,[H-].[Na+],val
US04124707,CC(=O)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C,,CC(=O)O,,I,,val
US05859007,BrBr.OCc1nn(Cc2ccccc2)c2ccccc12>>BrCc1nn(Cc2ccccc2)c2ccccc12,,CC#N,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160009744A1,Br.Nc1c(CCO)ccc(Cl)c1F>>OCCc1ccc(Cl)c(F)c1Br,[Cu]Br,O,,O=N[O-].[Na+],,val
US20010056203A1,O=C(OCc1ccccc1)c1ccc(Oc2ccc([N+](=O)[O-])c(OCc3ccccc3)c2)cc1>>Nc1ccc(Oc2ccc(C(=O)O)cc2)cc1O,[Pd],C1CCOC1,CCOC(C)=O,[H][H],,val
US05665696,C=CCCl.CC1(C)C2CCC(CC=O)C1C2>>C=CCC(C=O)C1CCC2CC1C2(C)C,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20100256126A1,CCOC(=O)C1(CC2CC2)CCN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CC1>>O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(CC2CC2)(C(=O)O)CC1,,CCO,,Cl,[Na+].[OH-],val
US20100183551A1,CC[N+](=O)[O-].O=Cc1ccccc1[N+](=O)[O-]>>CC(=Cc1ccccc1[N+](=O)[O-])[N+](=O)[O-],,CC(=O)O,CCOC(C)=O,C,O=C[O-].[NH4+],val
US04978665,CCCOc1cc(CN)ccc1OC.CCn1nc(O)c(Cl)c(Cl)c1=O>>CCCOc1cc(CNc2c(O)nn(CC)c(=O)c2Cl)ccc1OC,,O,,C1COCCO1,,val
US20150099777A1,CCOC(=O)c1cc(O)c(-c2ccc(F)cc2)c(OCC)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)c1cc(OCC)c(-c2ccc(F)cc2)c(OS(=O)(=O)C(F)(F)F)c1,,c1ccncc1,,,,val
US04450173,COC(=O)CCc1ccc(O)cc1.ClCC1CO1>>COC(=O)CCc1ccc(OCC2CO2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050153962A1,CCOC(=O)c1csc(N(C(=O)c2ccccc2Cl)c2ccc(Cl)cc2)n1>>O=C(O)c1csc(N(C(=O)c2ccccc2Cl)c2ccc(Cl)cc2)n1,,C1COCCO1,,CC(=O)O,Cl,val
US04416683,CCC(C)(CC)c1nnc(N)s1.CCc1cccc(CC)c1C(=O)Cl>>CCc1cccc(CC)c1C(=O)Nc1nnc(C(C)(CC)CC)s1,,Cc1ccccc1,,,,val
US20040122057A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)C(OCC)c1c(F)cc(OS(=O)(=O)C(F)(F)F)cc1F>>CCOC(=O)C(OCC)c1c(F)cc(B2OC(C)(C)C(C)(C)O2)cc1F,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US05139687,C#CC(C)(O)CC(C)C.OC[C@H]1O[C@@H]2O[C@@H]3[C@@H](CO)O[C@H](O[C@@H]4[C@@H](CO)O[C@H](O[C@@H]5[C@@H](CO)O[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@@H]7[C@@H](CO)O[C@H](O[C@@H]8[C@@H](CO)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)O[C@@H]6CO)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O>>C#CC(C)(O)CC(C)C.OC[C@H]1O[C@@H]2O[C@@H]3[C@@H](CO)O[C@H](O[C@@H]4[C@@H](CO)O[C@H](O[C@@H]5[C@@H](CO)O[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@@H]7[C@@H](CO)O[C@H](O[C@@H]8[C@@H](CO)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)O[C@@H]6CO)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O,,O,,,,val
US20150232463A1,Cc1nc(C)c([C@H](OC(C)(C)C)C(=O)OC(C)C)c(N2CC(F)(F)C2)c1-c1ccc(OCCc2ccc(F)cc2)cc1>>Cc1nc(C)c([C@H](OC(C)(C)C)C(=O)O)c(N2CC(F)(F)C2)c1-c1ccc(OCCc2ccc(F)cc2)cc1,,CCO,,Cl,[Na+].[OH-],val
US20100256124A1,C=CCc1c(OC)ccc2ccc(=O)n(C)c12.O=[Os](=O)(=O)=O>>COc1ccc2ccc(=O)n(C)c2c1CC=O,O=[Os](=O)(=O)=O,C1COCCO1,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US04169855,CN.CSC(=C[N+](=O)[O-])SC>>CNC(C[N+](=O)[O-])SC,,ClCCCl,,CCO,,val
US20020107278A1,CCO.Fc1ccc2cc[nH]c2c1.O=C(Cl)C(=O)Cl>>CCOC(=O)C(=O)c1c[nH]c2cc(F)ccc12,,C1CCOC1,,O=C([O-])O.[Na+],,val
US08053463B2,COC(=O)/C=C/c1c[nH]c2ccc(Cl)cc12>>COC(=O)CCc1c[nH]c2ccc(Cl)cc12,[Pd],CCOC(C)=O,,[H][H],,val
US20030225141A1,CC(N)=NC(=S)NCCCNC(=O)OC(C)(C)C.CCc1ccccc1C(=O)CBr>>CCc1ccccc1C(=O)c1sc(NCCCNC(=O)OC(C)(C)C)nc1C,,CN(C)C=O,ClCCl,CCN(CC)CC,,val
US20140142097A1,CNCCOC.Nc1ncc(-c2ccc(C(=O)O)cc2)cc1C(=O)Nc1ccncc1>>COCCN(C)C(=O)c1ccc(-c2cnc(N)c(C(=O)Nc3ccncc3)c2)cc1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05071468,C=CCBr.O=[N+]([O-])c1c(O)cccc1Cl>>C=CCOc1cccc(Cl)c1[N+](=O)[O-],,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150073011A1,C=CCON1C(=O)N2C[C@H]1C(C)=C[C@H]2C(=O)OC>>C=CCON1C(=O)N2C[C@H]1C(C)=C[C@@H]2C(=O)O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20160122318A1,CCSc1ccc([C@H](CCO[Si](C)(C)C(C)(C)C)N[S@](=O)C(C)(C)C)nc1>>CCSc1ccc([C@@H](N)CCO)nc1,,ClCCl,,C1COCCO1,Cl,val
US20150307493A1,COC(=O)C(C)(C)N.O=[N+]([O-])c1cccc(Br)c1F>>COC(=O)C(C)(C)Nc1c(Br)cccc1[N+](=O)[O-],,CN1CCCC1=O,,Cl,O=C([O-])O.[Na+],val
US20040127576A1,CC12CCC(=O)C=C1CCc1cc(O)ccc12>>CC12CCCC=C1CCc1cc(O)ccc12,,CC#N,,,,val
US20090240052A1,CC(=O)Oc1ccc(/C=C/C(=O)Nc2cc(Oc3ccccc3)ccc2C(=O)OC(C)(C)C)cc1>>CC(=O)Oc1ccc(/C=C/C(=O)Nc2cc(Oc3ccccc3)ccc2C(=O)O)cc1,,O=C(O)C(F)(F)F,,,,val
US20080119518A1,CCN(CC)S(F)(F)F.COc1ccc(OC)c(C(O)CN2CCC(n3ccc4ccc(C(N)=O)cc43)CC2)c1>>COc1ccc(OC)c(C(F)CN2CCC(n3ccc4ccc(C(N)=O)cc43)CC2)c1,,ClCCl,,O,O=C([O-])O.[Na+],val
US20110009380A1,CC(C)(C)OC(=O)N1CC(c2cccc3cc(S(=O)(=O)c4ccccc4)cnc23)C1.Cl>>Cl.O=S(=O)(c1ccccc1)c1cnc2c(C3CNC3)cccc2c1,,ClCCl,,,,val
US20080125468A1,CCC(=COC)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1>>CCC(C=O)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1,,C1CCOC1,,Cl,,val
US20050187223A1,CC(Cc1cccc(CN=[N+]=[N-])c1)Nc1nccc(N2CCCn3c2nc(-c2ccccc2)c([N+](=O)[O-])c3=O)n1>>CC(Cc1cccc(CN)c1)Nc1nccc(N2CCCn3c2nc(-c2ccccc2)c(N)c3=O)n1,[Pd],CO,,[H][H],,val
US20090118312A1,CI.Cc1c(O)ccc(C#N)c1N>>COc1ccc(C#N)c(N)c1C,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20150203511A1,CCOC(=O)C(=O)C(C)C(=O)c1ccc(OCc2c(C)cccc2-n2nnn(C)c2=O)c(C)c1.NN>>CCOC(=O)c1[nH]nc(-c2ccc(OCc3c(C)cccc3-n3nnn(C)c3=O)c(C)c2)c1C,,C1CCOC1,,,,val
US20090197863A1,CC1(C(=O)Cl)CCCN1C(=O)OCc1ccccc1.COC(=O)c1cccc(N)c1O>>COC(=O)c1cccc(NC(=O)C2(C)CCCN2C(=O)OCc2ccccc2)c1O,,ClCCl,,c1ccncc1,,val
US20130261125A1,CC(C)(C)OC(=O)NC1CCCC(F)(Cc2ccccc2F)C1>>NC1CCCC(F)(Cc2ccccc2F)C1,,C1COCCO1,,Cl,,val
US20030087905A1,Nc1cccc(Oc2ccccc2)c1.O=Cc1cccc(C2CCCC2)c1>>c1ccc(Oc2cccc(NCc3cccc(C4CCCC4)c3)c2)cc1,,ClCCCl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100331293A1,Cc1nc2c(Cl)cccc2c(Cl)c1C.Nc1cc(Br)ccc1N1CCOCC1>>Cc1nc2c(Cl)cccc2c(Nc2cc(Br)ccc2N2CCOCC2)c1C,,CO,,C1COCCO1,Cl,val
US20140213616A1,COc1cc(NC(=O)c2cc(C(F)(F)F)ccc2F)ccn1>>O=C(Nc1cc[nH]c(=O)c1)c1cc(C(F)(F)F)ccc1F,,CC#N,,C[Si](C)(C)I,,val
US05374625,CC(C)(C)[Si](OC[C@@H]1[C@@H](CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC[C@H]1n1cnc2c(N)ncnc21)(c1ccccc1)c1ccccc1>>Nc1ncnc2c1ncn2[C@@H]1CC[C@H](CO)[C@H]1CO,,CO,,C1COCCO1,Cl,val
US20080081810A1,COC(=O)C(CCCC(N)NC(=O)OC(C)(C)C)NC(=O)CNC(=O)c1ccc(Br)cc1NC1(Cc2cccc(Cl)c2)C(=O)Nc2cc(Cl)ccc21>>COC(=O)C(CCCCN)NC(=O)CNC(=O)c1ccc(Br)cc1NC1(Cc2cccc(Cl)c2)C(=O)Nc2cc(Cl)ccc21,,O=C(O)C(F)(F)F,,,,val
US20080293712A1,COc1cc2c(Cl)c(C#N)cnc2cc1OCc1ccccc1.C[Mg]Br>>COc1cc2c(C)c(C#N)cnc2cc1OCc1ccccc1,Cl[Cu],,,,,val
US20060247227A1,C1CC(N2CCC(OC3CCNCC3)CC2)C1.N#Cc1cc(F)c(F)cc1F>>N#Cc1cc(F)c(N2CCC(OC3CCN(C4CCC4)CC3)CC2)cc1F,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140336224A1,CCI.N#CC(c1ccc(Cl)cc1)c1n[nH]c2c([N+](=O)[O-])cccc12>>CCC(C#N)(c1ccc(Cl)cc1)c1n[nH]c2c([N+](=O)[O-])cccc12,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US07176310B1,Nc1ccc([N+](=O)[O-])cc1.O=C(O)COc1ncc(C(=O)Nc2ccc(F)cc2)cn1>>O=C(COc1ncc(C(=O)Nc2ccc(F)cc2)cn1)Nc1ccc([N+](=O)[O-])cc1,,CO,ClCCl,,,val
US20080027070A1,Nc1ccc(Cl)c(C(=O)O)c1.O=C(Cl)c1cccc(Cl)c1>>O=C(Nc1ccc(Cl)c(C(=O)O)c1)c1cccc(Cl)c1,,C1CCOC1,,,,val
US20050215789A1,COC(=N)N.O=C1OC(Cc2ccccc2)=NC1=CO>>COc1ncc(NC(=O)Cc2ccccc2)c(=O)[nH]1,,CC#N,,Cl,[Na],val
US20040157866A1,COC(=O)C1CCCCCC1=O.O=S(=O)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>COC(=O)C1=C(OS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)CCCCC1,,CCOC(C)=O,CN(C)C=O,Cl,[H-].[Na+],val
US20080004269A1,CCCc1nc(Cl)cnc1Cc1ccnn1-c1ncccc1C#N>>CCCc1nccnc1Cc1ccnn1-c1ncccc1C#N,[Pd],CCO,,,,val
US05175162,CCc1cc2c(s1)SCCc1cc(=O)[nH]nc1-2.CI>>CCc1cc2c(s1)SCCc1cc(=O)n(C)nc1-2,,CN(C)C=O,,[H-].[Na+],,val
US05223498,CC1CCN(Cc2ccccc2)C1=O.Nc1ccccc1N1CCOCC1>>CC1CCN(Cc2ccccc2)C1=Nc1ccccc1N1CCOCC1,,c1ccccc1,,O=P(Cl)(Cl)Cl,,val
US05472984,Brc1ccc2c(c1)CCC2OC1CCCCO1.CN(C)C=O>>O=Cc1ccc2c(c1)CCC2OC1CCCCO1,,C1CCOC1,,CCOCC,[Cl-].[NH4+],val
US20110009398A1,CN(C)C(=O)Oc1cc2oc(=O)c(Cc3cccc(NS(=O)(=O)NOC(=O)OC(C)(C)C)c3)c(CF)c2cc1Cl>>CN(C)C(=O)Oc1cc2oc(=O)c(Cc3cccc(NS(N)(=O)=O)c3)c(CF)c2cc1Cl,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20140303164A1,CN1CCN(S(=O)(=O)Nc2nn(C)c3c(-c4ccc(C#CC(C)(C)O)nc4[C@@H](N)Cc4cc(F)cc(F)c4)cccc23)CC1.O=C(Cn1nc(C(F)(F)F)c2c1C(F)(F)[C@@H]1C[C@H]21)ON1C(=O)CCC1=O>>CN1CCN(S(=O)(=O)Nc2nn(C)c3c(-c4ccc(C#CC(C)(C)O)nc4[C@H](Cc4cc(F)cc(F)c4)NC(=O)Cn4nc(C(F)(F)F)c5c4C(F)(F)[C@@H]4C[C@H]54)cccc23)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4nncn4CCC)c(C)c2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4nncn4CCC)c(C)c2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20070203136A1,CCOC(=O)C(F)(F)c1ccc2occc2c1.NN>>NNC(=O)C(F)(F)c1ccc2occc2c1,,CO,,,,val
US20150051410A1,O=C1C[C@@H]2[C@@H](/C=C/[C@H](COc3cccc(C(F)(F)F)c3)OC3CCCCO3)[C@H](OC3CCCCO3)C[C@@H]2O1>>OC1C[C@@H]2[C@@H](/C=C/[C@H](COc3cccc(C(F)(F)F)c3)OC3CCCCO3)[C@H](OC3CCCCO3)C[C@@H]2O1,,Cc1ccccc1,,CC(C)C[AlH]CC(C)C,,val
US20120208844A1,BrC(Br)(Br)Br.COC(=O)C[C@H]1CC[C@@H](O)C1>>COC(=O)C[C@H]1CC[C@H](Br)C1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160176864A1,Cc1nnn(C)c1-c1cnc2c(c1)[nH]c1cccc(S(C)(=O)=O)c12.O[C@@H](c1ccc(F)cc1)C1CCOCC1>>Cc1nnn(C)c1-c1cnc2c3c(S(C)(=O)=O)cccc3n([C@H](c3ccc(F)cc3)C3CCOCC3)c2c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080076745A1,CC(C)(C)OC(=O)NCCC[C@@H](CC(=O)O)NC(=O)OCc1ccccc1.CC(C)(C)OC(=O)NCCC[C@@H](CN)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NCCC[C@@H](CNC(=O)C[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20090275593A1,CCOC(=O)c1cnn2c(N)c(-c3ccc([N+](=O)[O-])cc3)cnc12>>CCOC(=O)c1cnn2c(N)c(-c3ccc(N)cc3)cnc12,[Pd],C1CCOC1,CCO,,,val
US04246274,OC(CCl)(Cc1ccc(Cl)cc1Cl)c1ccc(C2CCCCC2)cc1.c1c[nH]cn1>>OC(Cc1ccc(Cl)cc1Cl)(Cn1ccnc1)c1ccc(C2CCCCC2)cc1,,CC#N,,[H-].[Na+],,val
US20110070317A1,CC(C)(C)OC(=O)N[C@@H]1CN(Cc2ccccc2)CC[C@H]1C1CC1>>CC(C)(C)OC(=O)N[C@@H]1CNCC[C@H]1C1CC1,[Pd],CO,,[H][H],,val
US20140194620A1,CC(C)(C)c1cn(COc2ccc3ccccc3c2)nn1.COS(=O)(=O)C(F)(F)F>>Cn1n[n+](COc2ccc3ccccc3c2)cc1C(C)(C)C.O=S(=O)([O-])C(F)(F)F,,CC#N,,,,val
US20050059663A1,CCOC(=O)C1CCNCC1.O=C(O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F>>O=C(O)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1,,CC(=O)N(C)C,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04628057,CC[C@@H]1N[C@H](C(=O)O)Cc2c1[nH]c1ccccc21.CI.S=C=S>>CC[C@H]1c2[nH]c3ccccc3c2C[C@@H](C(=O)O)N1C(=S)SC,,CO,O,CCN(CC)CC,,val
US20130310380A1,C[C@H]1CN(c2cccc(Cl)c2)C[C@@H](C)O1.Cc1occc1B1OC(C)(C)C(C)(C)O1>>Cc1occc1-c1cccc(N2C[C@H](C)O[C@H](C)C2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20120289496A1,NCCO.O=[N+]([O-])c1ccc(F)c(F)c1>>O=[N+]([O-])c1ccc(NCCO)c(F)c1,,CC#N,,,,val
US20110237607A1,CC(=O)CC(C)=O.Cn1cnc2c(NC3Cc4ccccc4C3)nc(NN)nc21>>Cc1cc(C)n(-c2nc(NC3Cc4ccccc4C3)c3ncn(C)c3n2)n1,,CCO,,,,val
US20130079328A1,Cc1cc(-c2ncc(CN)cc2C)ccn1.O=C(O)c1ccc(-c2cnccn2)cn1>>Cc1cc(-c2ncc(CNC(=O)c3ccc(-c4cnccn4)cn3)cc2C)ccn1,,CN(C)C=O,CS(C)=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050054626A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@H](NC(=O)OCc2ccccc2)[C@H](C(N)=S)C1.CCC(=O)CCl>>CCc1csc([C@@H]2C[C@H](NC(=O)OC(C)(C)C)CC[C@@H]2NC(=O)OCc2ccccc2)n1,,c1ccccc1,,,,val
US20130336921A1,CC(C)(C)OC(=O)CCSCc1cccc(C(=O)O)c1.Cc1ccc(-n2ccc(NC(=O)c3cc(N4CCCCC4)ccc3N)n2)cc1C>>Cc1ccc(-n2ccc(NC(=O)c3cc(N4CCCCC4)ccc3NC(=O)c3cccc(CSCCC(=O)OC(C)(C)C)c3)n2)cc1C,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20120190701A1,COC(=O)c1cc(Br)nc2ccccc12.COC/C=C/B1OC(C)(C)C(C)(C)O1>>COC/C=C/c1cc(C(=O)OC)c2ccccc2n1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20160052884A1,Br[Mg]CC1CC1.CCOC(=O)C=O>>CCOC(=O)C(O)CC1CC1,,C1CCOC1,CCOC(C)=O,,,val
US20030199440A1,COC(=O)c1ccc(OC)c(NS(=O)(=O)c2ccc3c(Cl)cnc(NC(=N)N)c3c2)c1.Cl>>COc1ccc(C(=O)O)cc1NS(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1.Cl,,C1COCCO1,,[Na+].[OH-],,val
US04115431,CC=CC(=O)CC.COC(=O)CC#N>>CC1C(=O)CC(C)C(C#N)C1=O,,CO,,C[O-].[Na+],,val
US20080275097A1,COc1ccc(CN)cc1.COc1ccc(Cn2nc(C(=O)OC(C)(C)C)c3ccc(F)nc32)cc1>>COc1ccc(CNc2ccc3c(C(=O)OC(C)(C)C)nn(Cc4ccc(OC)cc4)c3n2)cc1,,CN1CCCC1=O,O,,,val
US20060205726A1,CN(C)C(=O)c1cc(OCc2ccccc2)ccc1N.O=C(Cl)c1ccccc1-c1ccc(C(F)(F)F)cc1>>CN(C)C(=O)c1cc(OCc2ccccc2)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1,,CCOC(C)=O,,CCN(CC)CC,,val
US20110105470A1,CC(C)(C)OC(=O)N1CCC(O)(CSC2=CC(=O)C(=O)c3ccccc32)CC1.Cl.ClCCl>>O=C1C(=O)c2ccccc2C2=C1SCC1(CC[NH2+]CC1)O2.[Cl-],,C1COCCO1,ClCCl,O=C(O)C(F)(F)F,,val
US20050277655A1,CC(=O)c1cnc(Cl)nc1Cl.NN>>Cc1n[nH]c2nc(Cl)ncc12,,C1CCOC1,,,,val
US20130310380A1,COCN.Cc1occc1C(=O)Cl>>CON(C)C(=O)c1ccoc1C,,ClCCl,O,CCN(CC)CC,Cl,val
US20090036469A1,COc1nc(Cl)cc(NCCc2ccc(OC(F)(F)F)cc2)n1.O=C(O)C1CCCNC1>>COc1nc(NCCc2ccc(OC(F)(F)F)cc2)cc(N2CCCC(C(=O)O)C2)n1,,CN1CCCC1=O,O,O=C([O-])[O-].[K+].[K+],,val
US20130210824A1,COC(=O)C(=O)C(C)(C)C(=O)OC.Cc1ncc2c(C(=N)NN)nn(Cc3cccc(F)c3F)c2n1>>COC(=O)C(C)(C)c1nnc(-c2nn(Cc3cccc(F)c3F)c3nc(C)ncc23)nc1O,,CCO,,,,val
US07005440B1,CCOC(=O)c1c(C)cc(OCc2ccccc2)cc1OCc1cccc(OCc2ccc3ccccc3n2)c1>>Cc1cc(OCc2ccccc2)cc(OCc2cccc(OCc3ccc4ccccc4n3)c2)c1C(=O)O,,CCO,,[Na+].[OH-],,val
US20030125370A1,C1CN(C2CC2)CCN1.CN(C)C=O.Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)O>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCN(CC2CC2)CC1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20060247289A1,CC(C)Oc1ccc(C(=O)O)cc1C#N.NN>>CC(C)Oc1ccc(C(=O)NN)cc1C#N,,C1CCOC1,,O,O=C(n1ccnc1)n1ccnc1,val
US04077982,O=Cc1ccccc1F.OCC(O)CO>>OC1COC(c2ccccc2F)OC1,,CCOCC,,O=S(=O)(O)O,,val
US05041462,CC(=O)OCC(=O)Cl.N#Cc1c(N)cccc1[N+](=O)[O-]>>CC(=O)OCC(=O)Nc1cccc([N+](=O)[O-])c1C#N,,c1ccncc1,,,,val
US20140051676A1,Cc1cccc(N(C)c2nc(N)nc(C(=N)NO)n2)c1.O=C(OC(=O)C(Cl)(Cl)Cl)C(Cl)(Cl)Cl>>CN(c1ccccc1)c1nc(N)nc(-c2noc(C(Cl)(Cl)Cl)n2)n1,,CCOC(C)=O,Cc1ccccc1,c1ccncc1,,val
US05206240,CC(O)CCCCCO.CS(=O)(=O)Cl>>CC(O)CCCCCOS(C)(=O)=O,,ClCCl,,c1ccncc1,,val
US20100009969A1,O=C(O)C1Cc2nc(-c3ccc(OCCCCl)cc3)sc2C1.OCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>O=C(NC1Cc2nc(-c3ccc(OCCCCl)cc3)sc2C1)OCc1ccccc1,,Cc1ccccc1,,CCN(CC)CC,,val
US05563141,Cc1ccc(S(=O)(=O)NCc2ccc(C(=O)CBr)cc2)cc1.c1cc(N2CCNCC2)ccn1>>Cc1ccc(S(=O)(=O)NCc2ccc(C(=O)CN3CCN(c4ccncc4)CC3)cc2)cc1,,CC#N,,,,val
US20070066820A1,COc1ccc(Oc2ccc(C)cc2)cc1>>Cc1ccc(Oc2ccc(O)cc2)cc1,,ClCCl,,BrB(Br)Br,,val
US05275950,CC(=O)CC(=O)O.CC(=O)OC(C)=O.c1ccc(CC2CCCCC2)cc1>>CC(=O)O[C@H]1C=CC=C(CC2CCCCC2)[C@H]1OC(C)=O,,c1ccncc1,,,,val
US20160108035A1,CCOC(=O)C1(Br)CCC1.FC(F)(F)c1ccc2nccc(S)c2c1>>CCOC(=O)C1(Sc2ccnc3ccc(C(F)(F)F)cc23)CCC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070219235A1,O=[N+]([O-])c1ccc(F)cc1Cl.Oc1ccc2cn[nH]c2c1>>O=[N+]([O-])c1ccc(Oc2ccc3cn[nH]c3c2)cc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05116862,C#CCC/C=C/C(=O)OCC>>C#CCC/C=C/C(=O)O,,CO,,,,val
US20100093757A1,Cc1ccc(NC(=O)[C@H](COCCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)Oc2ncnc3c2nnn3-c2ccccc2Cl)nc1>>Cc1ccc(NC(=O)[C@H](COCCO)Oc2ncnc3c2nnn3-c2ccccc2Cl)nc1,,CO,,Cl,,val
US20120276018A1,O=C(CBr)c1ccccc1.O=C(OC(c1cccc(F)c1)c1cccc(F)c1)C1CN2CCC1CC2>>O=C(C[N+]12CCC(CC1)C(C(=O)OC(c1cccc(F)c1)c1cccc(F)c1)C2)c1ccccc1.[Br-],,CC#N,,,,val
US20130102611A1,CC1CCc2cc(-c3ccccc3)c(-c3ccccc3)nc2N1.CCOC(=O)CCCCCCBr>>CCOC(=O)CCCCCCN1c2nc(-c3ccccc3)c(-c3ccccc3)cc2CCC1C,,CN1CCCC1=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110306599A1,CC1(C)CCc2c(-c3cc4ccc(NC(=O)OCc5ccccc5)cc4n3COCC[Si](C)(C)C)nn(COCC[Si](C)(C)C)c2C1.CI>>CN(C(=O)OCc1ccccc1)c1ccc2cc(-c3nn(COCC[Si](C)(C)C)c4c3CCC(C)(C)C4)n(COCC[Si](C)(C)C)c2c1,,CN(C)C=O,O,CCOC(C)=O,[H-].[Na+],val
US20160168139A1,C1CCNC1.C=C(OCC)c1ncc(COS(C)(=O)=O)cn1>>CC(=O)c1ncc(CN2CCCC2)cn1,,CN(C)C=O,,,,val
US20060094767A1,CC1(CSc2nnnn2-c2ccccc2)CO1.O=[N+]([O-])c1c[nH]c(Cl)n1>>CC(O)(CSc1nnnn1-c1ccccc1)Cn1cc([N+](=O)[O-])nc1Cl,,CCO,,CC(=O)[O-].[Na+],,val
US20110281870A1,N[C@H]1CC[C@@H]2CN(c3cccc(C(F)(F)F)n3)C[C@H]12.O=C=Nc1ccc(F)cc1>>O=C(Nc1ccc(F)cc1)N[C@H]1CC[C@@H]2CN(c3cccc(C(F)(F)F)n3)C[C@H]12,,CCOCC,ClCCl,,,val
US20070172385A1,Nc1ccc2c(c1)S(=O)(=O)CC2.[I-]>>O=S1(=O)CCc2ccc(I)cc21,,O,,O=N[O-].[Na+],,val
US20110245257A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ncccc1Nc1ccccn1>>CC(NC(=O)OC(C)(C)C)c1nc2ncccc2n1-c1ccccn1,,CC(=O)O,,,,val
US20150361100A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.COC(=O)c1cc2cccnn2c1Br>>COC(=O)c1cc2cccnn2c1-c1ccccn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,,,val
US20090082390A1,CC(C)(C)OC(=O)N1CCCCC1Cc1nnc(-c2ccccc2)o1>>c1ccc(-c2nnc(CC3CCCCN3)o2)cc1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US04031107,C1CCNCC1.COn1c(C(F)(F)F)nc2c([N+](=O)[O-])cc([N+](=O)[O-])cc21>>O=[N+]([O-])c1cc([N+](=O)[O-])c2[nH]c(C(F)(F)F)nc2c1N1CCCCC1,,CO,,ClC(Cl)Cl,,val
US20040014802A1,Nc1n[nH]c2cc(Cl)ccc12.O=C(Cl)c1cccs1>>O=C(Nc1n[nH]c2cc(Cl)ccc12)c1cccs1,,c1ccncc1,,,,val
US05025015,CNc1ccc(Cl)cc1Cc1ccccc1.O=C(Br)CBr>>CN(C(=O)CBr)c1ccc(Cl)cc1Cc1ccccc1,,CCOC(C)=O,,,,val
US20080009492A1,COCCOc1cccc(C#Cc2cc([N+](=O)[O-])cnc2N)c1>>COCCOc1cccc(-c2cc3cc([N+](=O)[O-])cnc3[nH]2)c1,,CN(C)C=O,,C1CCOC1,CC(C)(C)[O-].[K+],val
US20040236109A1,CC(=O)N1c2ccc(N)cc2C(C)(c2ccccc2)CC1(C)C.CC(=O)Nc1ccc(Br)cc1C(=O)O>>CC(=O)Nc1ccc(Br)cc1C(=O)Nc1ccc2c(c1)C(C)(c1ccccc1)CC(C)(C)N2C(C)=O,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090054425A1,Cc1ccc(S(=O)(=O)n2cc(I)c3c(Cl)nc(Cl)nc32)cc1.Nc1ccc2cn[nH]c2c1>>Cc1ccc(S(=O)(=O)n2cc(I)c3c(Nc4ccc5cn[nH]c5c4)nc(Cl)nc32)cc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20140364433A1,Cc1cccnc1C(N)=O>>C[C@H]1CCCN[C@H]1C(N)=O,O=[Pt]=O,CC(=O)O,,,,val
US20060270609A1,O=C1c2ccccc2C(=O)N1[C@@H]1CC[C@@H](O)CC1.Oc1ccc(F)cc1>>O=C1c2ccccc2C(=O)N1[C@@H]1CC[C@H](Oc2ccc(F)cc2)CC1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100330064A1,NCCC[C@@]1(C(=O)O)CCC[C@@H]1S.O=P(O)(O)O>>NCCC[C@@]1(C(=O)O)CCC[C@@H]1S.O=P(O)(O)O,,O,,,,val
US20020133026A1,NCCC(=O)N1CCOCC1.O=C(O)Cc1ccccc1>>NCCC(=O)N1CCOCC1.O=C(O)Cc1ccccc1,,CO,,Cl,C[O-].[Na+],val
US20100099713A1,Cc1ncccc1Oc1cc(Nc2nc(C3CCN(C(=O)OC(C)(C)C)CC3)cs2)ncc1Sc1ccnc2ccsc12.Cl.ClCCl>>Cc1ncccc1Oc1cc(Nc2nc(C3CCNCC3)cs2)ncc1Sc1ccnc2ccsc12.Cl.Cl,,ClCCl,,,,val
US20110152243A1,CCOC(=O)Cc1cn(C(=O)OC(C)(C)C)c2sccc12.O=[Se]=O>>CCOC(=O)C(=O)c1cn(C(=O)OC(C)(C)C)c2sccc12,,O,,C1CCOC1,,val
US04474700,CCN(CC)CC.CCOCC.COC(=O)C(F)(F)C(F)(F)N=[N+]=[N-]>>CC[N+](C)(CC)CC.[N-]=[N+]=NC(F)(F)C(F)(F)C(=O)[O-],,CCOCC,,,,val
US05424320,CC1=CC(=O)CC(COCc2ccccc2)O1>>CC12CC(=O)CC(CO1)O2,[Pd],CCOC(C)=O,,,,val
US20020120139A1,BrCCCCCCCBr.Sc1ccc(Cl)cc1>>Clc1ccc(SCCCCCCCBr)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080171772A1,CC(C)Oc1ccc2c(C(=O)NCc3ccc(F)c(F)c3)c(C(=O)NCCO)n(Cc3ccccn3)c2c1>>CC(C)Oc1ccc2c(C(=O)NCc3ccc(F)c(F)c3)c(C3=NCCO3)n(Cc3ccccn3)c2c1,,CCOC(C)=O,ClCCl,CCN(CC)CC,CS(=O)(=O)Cl,val
US20070149506A1,CCI.Sc1cc(Cl)cc(Cl)c1>>CCSc1cc(Cl)cc(Cl)c1,,O,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20030225038A1,CCCn1c(=O)c2[nH]c(C3CC4CCC(O)C3C4)nc2n(CCC)c1=O>>CCCn1c(=O)c2[nH]c(C3CC4CCC(=O)C3C4)nc2n(CCC)c1=O,,CCOCC,ClCCl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US04329518,CCc1c(C(=O)O)cccc1-c1ccccc1>>CCc1c(CO)cccc1-c1ccccc1,,C1CCOC1,ClCCl,O,,val
US20080207654A1,CCCCc1nn(CC2CCCCO2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCCc1nn(CC2CCCCO2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20060100229A1,CCCCc1c2c(nn1C(C)(C)C)c(N)nc1ccccc12.Cl>>CCCCc1[nH]nc2c(N)nc3ccccc3c12.Cl,,O,,,,val
US20130230542A1,BrCCCCBr.Oc1ccc(O)cc1>>Oc1ccc(OCCCCBr)cc1,,CO,,[K+].[OH-],,val
US20140073627A1,CNCc1ccc(CN2CCC(OC)C2)cc1.COC(=O)c1nnc(CN(C)S(=O)(=O)c2c(C)cc(OC)cc2C)o1>>COc1cc(C)c(S(=O)(=O)N(C)Cc2nnc(C(=O)N(C)Cc3ccc(CN4CCC(OC)C4)cc3)o2)c(C)c1,,ClCCCl,,C[Al](C)C,,val
US20100004301A1,CC(C)Oc1ccc(-c2ccc(O)c([N+](=O)[O-])c2)cc1>>CC(C)Oc1ccc(-c2ccc(O)c(N)c2)cc1,[Pd],CCO,CCOC(C)=O,,,val
US03947449,CC1(C)CC(=O)c2c(n(O)c3ccc(Cl)cc3c2=O)C1>>CC1(C)CC(=O)c2c([nH]c3ccc(Cl)cc3c2=O)C1,,ClC(Cl)Cl,,ClP(Cl)Cl,,val
US20050209226A1,CCCCC1CCNCC1.Cc1cccc2c1ccc(=O)n2CCCCl>>CCCCC1CCN(CCCn2c(=O)ccc3c(C)cccc32)CC1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20150111935A1,CCOC(=O)/C=C/C=C/CCc1ccccc1>>O=C(O)/C=C/C=C/CCc1ccccc1,,CO,,Cl,[Na+].[OH-],val
US20040138286A1,Cc1c(O[C@@H]2CCC[C@H](Nc3ccccc3)C2)ccc2c1cnn2C1CCCCO1>>Cc1c(O[C@@H]2CCC[C@H](Nc3ccccc3)C2)ccc2[nH]ncc12,,CC(C)O,,C1COCCO1,Cl,val
US20080306096A1,COc1cc2ncnc(Cl)c2cc1OC.Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1N>>COc1cc2ncnc(Nc3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3C)c2cc1OC,,CCO,,,,val
US04375547,CNCc1nc(CSCCN)cs1.CSC1C([N+](=O)[O-])N1C>>CNCc1nc(CSCCNC(=C[N+](=O)[O-])NC)cs1,,O,,,,val
US05753679,Clc1cccc(CBr)c1.OC1CCNCC1>>OC1CCN(Cc2cccc(Cl)c2)CC1,,CN(C)C=O,,,,val
US20060264438A1,COC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1C(=O)OCc1ccccc1>>COC(=O)[C@@H]1CNCC[C@H]1C(=O)OCc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160272655A1,CCc1nc(C)ccc1OCC(=O)OC(C)(C)C>>CCc1nc(C)ccc1OCC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US06476038B1,Cc1cc(NCCN(C(=O)OC(C)(C)C)C2CCCC2)n2nc(C)c(I)c2n1.OB(O)c1cccc(Cl)c1Cl>>Cc1cc(NCCN(C(=O)OC(C)(C)C)C2CCCC2)n2nc(C)c(-c3cccc(Cl)c3Cl)c2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20050101614A1,Cc1cc(C)c(-c2cccc3c(C(C)O)n(C)nc23)c(C)c1>>C=Cc1c2cccc(-c3c(C)cc(C)cc3C)c2nn1C,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20060142265A1,CN.Cn1ccc2cc(C=O)ccc21>>CNCc1ccc2c(ccn2C)c1,,CO,,O,[BH4-].[Na+],val
US20090258866A1,C=CCCC(O)(CCC=C)c1cccc(F)c1F>>OC1(c2cccc(F)c2F)CCC=CCC1,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,ClCCl,,,,val
US20100249099A1,CS(=O)(=O)Cl.FC(F)c1nc2ccccc2n1-c1nc(N2CCNCC2)nc(N2CCOCC2)n1>>CS(=O)(=O)N1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1,,C1CCOC1,,CCN(CC)CC,O,val
US20070213331A1,CCCN(C)C(=O)c1cc(C(=O)OCC)cc(C(=O)N2CCCC2C)c1>>CCCN(C)C(=O)c1cc(C(=O)O)cc(C(=O)N2CCCC2C)c1,,O,,C1CCOC1,[Li+].[OH-],val
US04388463,CC(=O)OC(C)=O.CN1CC[C@]23CC(=O)CC[C@H]2[C@H]1Cc1cccc(O)c13>>CC(=O)Oc1cccc2c1[C@]13CCN(C)[C@H](C2)[C@@H]1CCC(=O)C3,,c1ccncc1,,,,val
US07012074B2,O=C(O)[C@H]1CC[C@@H](C(=O)O)N1Cc1ccccc1>>O=C1OC(=O)C2CCC1N2Cc1ccccc1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150152047A1,CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@H](C(=O)O)C2)c(C(F)(F)F)c1.CNC>>CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@H](C(=O)N(C)C)C2)c(C(F)(F)F)c1,,CC#N,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04235776,CC(=O)NC1CCc2cn(C(C)=O)cc2C1>>NC1CCc2c[nH]cc2C1,,O,,CCO,[Na+].[OH-],val
US20030180662A1,C=CC(=O)Cl.OC12CCCC1(O)C1CCC2C1>>C=CC(=O)OC12CCCC1(O)C1CCC2C1,,C1COCCO1,,CCN(CC)CC,,val
US20140363454A1,CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)Oc1c(F)c(F)c(F)c(F)c1F.CCOC(=O)[C@@H](C)C[C@H](Cc1ccccc1)NC(=O)c1csc([C@H](O)C[C@H](C(C)C)N(C)C(=O)[C@@H](N)[C@@H](C)CC)n1>>CCOC(=O)[C@@H](C)C[C@H](Cc1ccccc1)NC(=O)c1csc([C@H](O)C[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H]2CCCCN2C(=O)OC(C)(C)C)[C@@H](C)CC)n1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20070072835A1,C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CC(C)(C)OC(=O)NCC(=O)O>>C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CC(C)(C)OC(=O)NCC(=O)O,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20130281438A1,CCOC(=O)[C@@H](C)C(C(=O)OCc1ccccc1)C(=O)OCc1ccccc1>>CCOC(=O)[C@@H](C)C(C(=O)O)C(=O)O,[Pd],CO,,,,val
US20100204240A1,COCC1OC2(CCCCC2)OC1C=NO.O=C1CCC(=O)N1Cl>>COC[C@@H]1OC2(CCCCC2)O[C@H]1C(Cl)=NO,,CN(C)C=O,,,,val
US20160176850A1,Clc1nc(Cl)nc(Cl)n1.OCC1CC1>>Clc1nc(Cl)nc(OCC2CC2)n1,,C1CCOC1,,[H-].[Na+],,val
US20160158207A1,CC1CN(c2nn(C3CCOCC3)c3c2CNCC3)c2cc(C(F)(F)F)c(-c3cnn(C)c3)cc2N1C.CNC(=O)n1ccnc1>>CNC(=O)N1CCc2c(c(N3CC(C)N(C)c4cc(-c5cnn(C)c5)c(C(F)(F)F)cc43)nn2C2CCOCC2)C1,,ClCCl,,CCN(CC)CC,,val
US20020156311A1,Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2ccc(OCCCC(=O)N[C@@H](CO)C(=O)OC(C)(C)C)cc2)cc1>>Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2ccc(OCCCC(=O)N[C@@H](CO)C(=O)O)cc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140142089A1,C1CCNC1.Clc1ccc2nc(-c3ccccc3)oc2n1>>c1ccc(-c2nc3ccc(N4CCCC4)nc3o2)cc1,,CN(C)C=O,,,,val
US20160009677A1,COc1cc(C)cc(CCO)c1>>COc1cc(C)cc(CC=O)c1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20040077696A1,CCOC(=O)c1ccc(N)nc1.O=C(N=C=S)c1ccccc1>>CCOC(=O)c1ccc(NC(N)=S)nc1,,C1CCOC1,CCO,C,C[O-].[Na+],val
US20080249138A1,COC(=O)c1cc(Cl)cc(CO)n1.O=S(Cl)Cl>>COC(=O)c1cc(Cl)cc(CCl)n1,,ClCCl,,Cc1ccccc1,,val
US20130317074A1,CC(=O)Oc1ccc([N+](=O)[O-])c(O)c1>>CC(=O)Oc1ccc(N)c(O)c1,[Pd],CCOC(C)=O,,,,val
US20090137557A1,Cc1nc(-c2cccc(OCc3ccccc3)c2F)n(CCc2ccccc2)c(=O)c1N=C(c1ccccc1)c1ccccc1>>Cc1nc(-c2cccc(OCc3ccccc3)c2F)n(CCc2ccccc2)c(=O)c1N,,C1CCOC1,,Cl,,val
US20090318411A1,CC(C)=O.Clc1nc(N2CCOCC2)c2ncn(C3CCCCO3)c2n1>>CC(C)(O)c1nc2c(N3CCOCC3)nc(Cl)nc2[nH]1,,C1CCOC1,,[Li]CCCC,,val
US20150166569A1,CC1(C)OB(c2cc[nH]n2)OC1(C)C.NC(=O)c1nc2n(c1I)CCOc1cc(F)c(Br)cc1-2>>NC(=O)c1nc2n(c1-c1cc[nH]n1)CCOc1cc(F)c(Br)cc1-2,,CO,,O,,val
US20020049194A1,CC1(C)COC(c2ccc(Br)cc2)=N1.Cc1ccccc1C=O>>Cc1ccccc1C(O)c1ccc(C2=NC(C)(C)CO2)cc1,,C1CCOC1,,[Mg],,val
US20030232875A1,Cc1ccc(S(=O)(=O)OCCCl)cc1.O=C(NCCc1ccccc1O)OCc1ccccc1>>O=C(NCCc1ccccc1OCCCl)OCc1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110098297A1,CCOC(=O)CC1CN=C(c2cc3cc(Oc4ccc(S(C)(=O)=O)nc4)cc(OC)c3[nH]2)S1>>COc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C3=NCC(CC(=O)O)S3)[nH]c12,,C1CCOC1,CCO,[Na+].[OH-],,val
US20120101137A1,CC(C)(C)OC(=O)CCNCC(=O)O.ClCc1ccccc1>>CCNCC(=O)OCc1ccccc1.Cl,,CC(C)=O,CCOC(C)=O,[I-].[K+],O=C([O-])O.[Na+],val
US07119203B2,CC(C)(C)OC(=O)C1(S(=O)(=O)N2CCC(CC=O)CC2)CCOCC1>>CC(C)(C)OC(=O)C1(S(=O)(=O)N2CCC(CCO)CC2)CCOCC1,,CO,,[BH4-].[Na+],,val
US20050137201A1,CN(C)C(OC(C)(C)C)N(C)C.NO.O=C(Cc1cccc(F)c1F)c1c[nH]c2ncc(C3CCC(NCc4ccccc4)CC3)cc12>>Fc1cccc(-c2cnoc2-c2c[nH]c3ncc(C4=CCC(NCc5ccccc5)CC4)cc23)c1F,,C1CCOC1,,Cl,CC(=O)[O-].[Na+],val
US20030073841A1,COc1cc2c(c3c1c(=O)c1cc4ccccc4c([N+](=O)[O-])c1n3C)C=CC(C)(C)O2>>COc1cc2c(c3c1c(=O)c1cc4ccccc4c(N)c1n3C)C=CC(C)(C)O2,[Zn],CC(=O)O,,O,,val
US20070078121A1,O=C(N1CCc2cc([N+](=O)[O-])ccc21)C(F)(F)F>>Nc1ccc2c(c1)CCN2C(=O)C(F)(F)F,[Pd],CO,,,,val
US20110269769A1,CCCC[Sn](CCCC)(CCCC)c1nccs1.Cn1c(-c2ccccn2)nc(-c2ccc(Br)cc2)c1Sc1ccc(Cl)cc1>>Cn1c(-c2ccccn2)nc(-c2ccc(-c3nccs3)cc2)c1Sc1ccc(Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20160046618A1,C#C[C@H](C)Oc1cnc(C(=O)OC(C)(C)C)c(C)n1>>C#C[C@H](C)Oc1cnc(C(=O)O)c(C)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070010556A1,CC(C)(C)OC(=O)N1CCCC[C@H](NC(=O)c2cc(-c3ccccc3)sc2NC(=O)NC(=O)C(Cl)(Cl)Cl)C1>>CC(C)(C)OC(=O)N1CCCC[C@H](NC(=O)c2cc(-c3ccccc3)sc2NC(N)=O)C1,,CO,,N,,val
US05530015,ClCc1ccccc1.Oc1ccc(Br)cc1C(F)(F)F>>FC(F)(F)c1cc(Br)ccc1OCc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070244131A1,CCC(=O)OB(O)c1ccccc1.COc1nc(Cl)cc(NCCc2ccc(Cl)cc2Cl)n1>>CCOC(=O)c1cccc(-c2cc(NCCc3ccc(Cl)cc3Cl)nc(OC)n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[Cs+].[Cs+],val
US20160000760A1,N#CN=C(Oc1ccccc1)Oc1ccccc1.Nc1ccc(-c2ccccc2)cc1>>N#C/N=C(/Nc1ccc(-c2ccccc2)cc1)Oc1ccccc1,,CC#N,,,,val
US20110021597A1,CCOC[C@H](O)[C@H]1CCN(C(=O)OC(C)(C)C)C1.Fc1ccc(Cl)cc1Cl>>CCOC[C@H](Oc1ccc(Cl)cc1Cl)[C@H]1CCNC1,,CN(C)C=O,Cl,CCO,[H-].[Na+],val
US20140221393A1,COc1ccc(N2CCN(c3ccc(-n4cnn(CCCCCCc5ccccc5)c4=O)cc3)CC2)cc1>>O=c1n(-c2ccc(N3CCN(c4ccc(O)cc4)CC3)cc2)cnn1CCCCCCc1ccccc1,,Br,,,,val
US07238716B2,COC(=O)Cc1ccccc1O.COc1cc(OCc2nc(-c3ccccc3)oc2C)ccc1CCl>>COc1cc(COc2ccccc2CC(=O)O)ccc1OCc1nc(-c2ccccc2)oc1C,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20080090825A1,COC(=O)/C(Cc1ccc(OCCNC(=O)OC(C)(C)C)cc1)=C(\C(=O)OC)C(C)C>>COC(=O)/C(Cc1ccc(OCCN)cc1)=C(\C(=O)OC)C(C)C,,CO,,Cl,ClCCl,val
US05024777,CCCCCCCCCCCCCCN(C)C.O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O.OO>>CCCCCCCCCCCCCC[N+](C)(C)[O-].O.O,,CCOC(C)=O,,,,val
US20140350043A1,CN(C)C=O.COc1cc(Br)cnc1OC>>COc1cc(C=O)cnc1OC,,C1CCOC1,,[Li]CCCC,,val
US20140349998A1,CNC.COC(=O)/C(C)=C/CBr>>COC(=O)/C(C)=C/CN(C)C,,C1CCOC1,,,,val
US20090018103A1,CCOC(=O)C1CCCN(S(=O)(=O)CC[Si](C)(C)C)C1>>C[Si](C)(C)CCS(=O)(=O)N1CCCC(CO)C1,,C1CCOC1,,[BH4-].[Li+],,val
US20040092737A1,Cl.NCc1ccc2c(c1)Nc1nccnc1S2>>Cl.NCc1ccc2c(c1)Nc1nccnc1S2,,CCOC(C)=O,,CO,,val
US20020035085A1,CC(=O)O[C@@H]1[C@@H](n2cnc3c(N)ncnc32)O[C@@H](COC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1>>Nc1ncnc2c1ncn2[C@H]1O[C@@H](COC(=O)c2ccccc2)[C@@H](OC(=O)c2ccccc2)[C@@H]1O,,c1ccncc1,,NN,O,val
US20150011532A1,CC(C)Nc1cc(Cl)ncc1C(=O)NN.O=C(n1ccnc1)n1ccnc1>>CC(C)Nc1cc(Cl)ncc1-c1n[nH]c(=O)o1,,CN(C)C=O,,,,val
US20060009456A1,CCOC(=O)C(CCC(=O)c1ccc(OC)c(C)c1C)N=C(c1ccccc1)c1ccccc1>>CCOC(=O)[C@H]1CC[C@@H](c2ccc(OC)c(C)c2C)N1,[Pd],CCO,,,,val
US20100267775A1,Cc1[nH]c(=O)ccc1Br.Cc1ccc(S(=O)(=O)OCCC(C)(C)O)cc1>>Cc1nc(OCCC(C)(C)O)ccc1Br,,CN(C)C=O,O,[H-].[Na+],[Cl-].[NH4+],val
US20100152163A1,CC(=CBr)c1ccc(Cl)cc1Cl.CN1CCc2[nH]c3ccc(Cl)cc3c2CC1>>C/C(=C\n1c2c(c3cc(Cl)ccc31)CCN(C)CC2)c1ccc(Cl)cc1Cl,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20050209291A1,Nc1nc2ccc(NC(=S)NC(=O)c3ccccc3)cc2s1>>NC(=S)Nc1ccc2nc(N)sc2c1,,C1CCOC1,,[Na+].[OH-],,val
US20060148858A1,CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.CCn1cc(CC(=O)OC)c(O)n1>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1nn(CC)cc1CC(=O)O,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20050282880A1,Fc1cccc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3ccc(CCl)cc23)c1.O[C@H]1CCOC1>>Fc1cccc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3ccc(CO[C@H]4CCOC4)cc23)c1,,C1CCOC1,O,[H-].[Na+],,val
US20090318408A1,CCOC(=O)C(F)(F)CN(c1nc(Cl)ncc1[N+](=O)[O-])C1CCC1>>O=C1Nc2cnc(Cl)nc2N(C2CCC2)CC1(F)F,[Fe],CC(=O)O,,,,val
US20120214785A1,CC(=O)Cl.CCCOc1ccc(C#Cc2ccc(C(C)CN)cc2)cc1>>CCCOc1ccc(C#Cc2ccc(C(C)CNC(C)=O)cc2)cc1,,ClCCl,,,,val
US20130210801A1,Cc1cc2[nH]c(=O)ccc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cc2nc(OS(=O)(=O)C(F)(F)F)ccc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C,,ClCCl,c1ccncc1,,,val
US20150023913A1,O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O.OC1CCOC1>>O=C(OC1CCOC1)ON1C(=O)CCC1=O,,CC#N,,,,val
US20130296377A1,COc1cc(C)c2c(ccn2C(=O)OC(C)(C)C)c1C(NCCO)(c1nc2cc(C#N)ccc2[nH]1)C(F)(F)F>>COc1cc(C)c2[nH]ccc2c1C(NCCO)(c1nc2cc(C#N)ccc2[nH]1)C(F)(F)F,,CO,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080269192A1,CC(C)(C)[Si](C)(C)OC[C@H](O)C1CCOCC1.CS(=O)(=O)Cl>>CC(C)(C)[Si](C)(C)OC[C@H](OS(C)(=O)=O)C1CCOCC1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20160207915A1,CN(CC(=O)O)C(=O)OC(C)(C)C.O=C1CCC(=O)N1O>>CN(CC(=O)ON1C(=O)CCC1=O)C(=O)OC(C)(C)C,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20140171403A1,CC1CC(CNC(=O)OC(C)(C)C)CCN1.O=C(Cl)OCc1cc(Cl)cc(Cl)c1>>CC1CC(CNC(=O)OC(C)(C)C)CCN1C(=O)OCc1cc(Cl)cc(Cl)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US20030004180A1,Cn1ncnc1CCl.O=c1[nH]c2c(cnn2-c2ccccc2)cc1Br>>Cn1ncnc1COc1nc2c(cnn2-c2ccccc2)cc1Br,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20090062297A1,CC(=O)OC(C)=O.CNC(=O)C(O)c1ccc(C(=O)Nc2cc(-c3cccs3)ccc2NC(=O)OC(C)(C)C)cc1>>CNC(=O)C(OC(C)=O)c1ccc(C(=O)Nc2cc(-c3cccs3)ccc2NC(=O)OC(C)(C)C)cc1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,c1ccncc1,,val
US20130041007A1,Cc1ccc(S(=O)(=O)n2c3c(c4cc(C#N)ccc42)CCCC3(O[Si](C)(C)C)C(F)(F)C(F)(F)F)cc1>>N#Cc1ccc2[nH]c3c(c2c1)CCCC3(O)C(F)(F)C(F)(F)F,,C1CCOC1,O,[K+].[OH-],,val
US20110269956A1,CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1nc(-c2ccc3cc(-c4ccc5[nH]c([C@@H]6C[C@H]7C[C@H]7N6C(=O)OC(C)(C)C)nc5c4)ccc3c2)c(Cl)[nH]1>>Clc1nc([C@@H]2C[C@H]3C[C@H]3N2)[nH]c1-c1ccc2cc(-c3ccc4[nH]c([C@@H]5C[C@H]6C[C@H]6N5)nc4c3)ccc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140364433A1,COc1ccc(CN2CCC[C@H](C)[C@@H]2C(N)=O)cc1>>COc1ccc(CN2CCC[C@H](C)[C@@H]2CN)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150210688A1,CI.Cc1nc(C2(O)COC2)n(COCC[Si](C)(C)C)c1I>>COC1(c2nc(C)c(I)n2COCC[Si](C)(C)C)COC1,,C1CCOC1,,[H-].[Na+],,val
US20150376192A1,CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cn[nH]c2n1.Fc1ccc(CCl)c(Cl)c1>>CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccc(F)cc3Cl)c2n1,,CC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20090181963A1,CC(C)(C)OC(=O)N1CC(n2nnc3c(N4CCOCC4)nc(-c4ccc(N)cc4)nc32)C1.Nc1cccnc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1CC(n2nnc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5ccncc5)cc4)nc32)C1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20090227575A1,Cn1ccc2c([N+](=O)[O-])cccc21>>Cn1ccc2c(N)cccc21,[Pd],CCO,,,,val
US05332717,CC(=O)Cl.COc1cc(OC)nc(Oc2cccc3c2C(=O)OC3O)n1>>COc1cc(OC)nc(Oc2cccc3c2C(=O)OC3OC(C)=O)n1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20140274958A1,COc1ccc(CC2SC3[C@H](/N=C\c4ccccc4O)C(=O)N3C(C(=O)[O-])=C2/C=C2\CCN([C@@H]3CCN(C(=O)OC(C)(C)C)C3)C2=O)cc1.COc1ccc(CO/N=C(\C(=O)OS(C)(=O)=O)c2nsc(N)n2)cc1>>Nc1nc(/C(=N/O)C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(/C=C4\CCN([C@@H]5CCNC5)C4=O)CS[C@H]23)ns1,,COC(C)(C)C,,ClCCl,O,val
US20160096839A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COCCn1ncc2cc(Cl)cc(Br)c21>>COCCn1ncc2cc(Cl)cc(B3OC(C)(C)C(C)(C)O3)c21,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20110046161A1,COC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)O[C@@H]1CCC[C@H]1CCCCCn1c(cccc1=O)O2.O=C1CCC(=O)N1Br>>COC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)O[C@@H]1CCC[C@H]1CCCCCn1c(ccc(Br)c1=O)O2,,CC#N,,,,val
US20100256097A1,CCOC(=O)CBr.OCCc1cccc(Br)n1>>CCOC(=O)COCCc1cccc(Br)n1,,C1CCOC1,CCOC(C)=O,O,[H-].[Na+],val
US20050176775A1,Cc1cc(O)cc(=O)o1.Cc1nc2cc(C)c(N)cc2s1>>Cc1nc2cc(C)c(-n3c(C)cc(O)cc3=O)cc2s1,,OCC(F)(F)F,,,,val
US20110098323A1,COC(=O)CS.Fc1cccc(N=C=S)c1>>O=C1CSC(=S)N1c1cccc(F)c1,,ClCCl,,CCN(CC)CC,,val
US20100120760A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(O)cc12.O=C1OCCC1Br>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(OC3CCOC3=O)cc12,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120115844A1,CCOC(=O)C#Cc1ccc(F)cc1.C[Si](C)(C)CN=[N+]=[N-]>>CCOC(=O)c1c(-c2ccc(F)cc2)nnn1C[Si](C)(C)C,,c1ccccc1,,,,val
US20150284411A1,CC1(C)OB(c2ccc(C3CCN(CC(F)(F)F)C3)cc2)OC1(C)C.C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@@H]3[C@H](O)CO[C@H]23)nc2nc(I)c(Cl)cc21>>C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@@H]3[C@H](O)CO[C@H]23)nc2nc(-c3ccc(C4CCN(CC(F)(F)F)C4)cc3)c(Cl)cc21,,C1COCCO1,ClCCl,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20110144081A1,CCOC(=O)Cl.CN[C@@H]1CN(C(=O)C2CCN(c3ccc(C#N)cn3)CC2)C[C@H]1c1ccc(Cl)cc1>>CCOC(=O)N(C)[C@@H]1CN(C(=O)C2CCN(c3ccc(C#N)cn3)CC2)C[C@H]1c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US05149699,O=C(O)c1ccc(Br)nc1>>OCc1ccc(Br)nc1,,C1CCOC1,,O,O=C([O-])[O-].[K+].[K+],val
US04416884,CN1CCNCC1.O=C(O)c1cn2c3c(c(Cl)ccc3c1=O)CCC2>>CN1CCN(c2ccc3c(=O)c(C(=O)O)cn4c3c2CCC4)CC1,,CS(C)=O,,Cl,,val
US20150158863A1,CCOC(=O)CN.Cc1cnc(Cl)c([N+](=O)[O-])c1>>CCOC(=O)CNc1ncc(C)cc1[N+](=O)[O-],,CCO,,CCN(CC)CC,Cl,val
US20160168090A1,CC(C)(C)OC(=O)N1CC(n2cc(C(=O)NCC3(O)CCC(F)(F)CC3)c3c(Cl)cccc32)C1>>O=C(NCC1(O)CCC(F)(F)CC1)c1cn(C2CNC2)c2cccc(Cl)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120202785A1,C[C@H](NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2n1-c1ccc(F)cn1>>C[C@H](N)c1nc2ccc(F)cc2n1-c1ccc(F)cn1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20070185324A1,CNc1ncc2cc(B3OC(C)(C)C(C)(C)O3)ccc2n1.Cc1ccc2c(Oc3cccc(C(F)(F)F)c3)nccc2c1I>>CNc1ncc2cc(-c3c(C)ccc4c(Oc5cccc(C(F)(F)F)c5)nccc34)ccc2n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20080306068A1,Cn1nc(C(C)(C)C)cc1NC(=O)Nc1cc(F)cc(OC2CCNCC2)c1.NC(=O)Oc1ccccc1>>Cn1nc(C(C)(C)C)cc1NC(=O)Nc1cc(F)cc(OC2CCN(C(N)=O)CC2)c1,,CCOC(C)=O,CS(C)=O,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20110144100A1,COCCOc1ccnc(Cl)c1.NN>>COCCOc1ccnc(NN)c1,,c1ccncc1,,,,val
US20150045378A1,CCOC(=O)CCc1cc(OCc2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)n2)ccc1C>>COc1ccc(F)c(-c2ccc(COc3ccc(C)c(CCC(=O)O)c3)nc2CC(C)(C)C)c1,,CO,,Cl,[Na+].[OH-],val
US20070244154A1,CC(=O)O[C@H]1C(=O)C2=C(N[C@@H]1c1ccccc1)c1nc(C)n(C)c1CC2C(=O)N(C)C>>CC(=O)O[C@H]1C(=O)c2c(C(=O)N(C)C)cc3c(nc(C)n3C)c2N[C@@H]1c1ccccc1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20020193402A1,COC[C@H](O[C@@H]1CC[C@H]2[C@H](C3=NNN(C)N3)C[C@]1(c1ccccc1)N2Cc1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>COC[C@H](O[C@@H]1CC[C@@H]2N[C@@]1(c1ccccc1)C[C@H]2C1=NNN(C)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,[Pd],CC(=O)O,,,,val
US20110034460A1,CCOC(=S)NN.O=C(CBr)c1ccc(Cl)cc1>>O=C1NN=C(c2ccc(Cl)cc2)CS1,,CC#N,,,,val
US20040147555A1,C=O.CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])cc2Cl)CC1>>CN1CCC(Oc2ccc([N+](=O)[O-])cc2Cl)CC1,,O=CO,,O=C([O-])[O-].[K+].[K+],,val
US20030186983A1,N#CC1CCN(Cc2ccn3ncnc(Nc4ccc5c(cnn5Cc5cccc(F)c5)c4)c23)CC1.[N-]=[N+]=[N-].[NH4+]>>Fc1cccc(Cn2ncc3cc(Nc4ncnn5ccc(CN6CCC(c7nnn[nH]7)CC6)c45)ccc32)c1,,CN(C)C=O,ClCCl,[Cl-].[Na+],,val
US20100240669A1,N#Cc1ccc(F)cc1.Nc1ccccc1Cl>>NCc1ccc(Nc2ccccc2Cl)cc1,[Ni],,,,,val
US20140163000A1,Cl.Nc1nn2cc(F)cnc2c1C(=O)Nc1cncc(F)c1N1CCC(C(=O)O)CC1>>Cl.Nc1nn2cc(F)cnc2c1C(=O)Nc1cncc(F)c1N1CCC(C(=O)O)CC1,,CN1CCCC1=O,,,,val
US20110288076A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(F)ccc1C[C@H]1CN[C@H](C(=O)O)C1>>Cc1cc(F)ccc1C[C@@H]1C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C1,,C1COCCO1,CC#N,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20100210662A1,CCOP(=O)(CC#N)OCC.CN1CCC(=O)CC1>>CN1CCC(=CC#N)CC1,,C1CCOC1,,O,O=C([O-])[O-].[K+].[K+],val
US20150203492A1,C=CC[C@H](NC(=O)OC(C)(C)C)c1cc(-c2ccccc2NC(=O)[C@H](C)C=C)ccn1>>C[C@@H]1C=CC[C@H](NC(=O)OC(C)(C)C)c2cc(ccn2)-c2ccccc2NC1=O,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US03959478,CCOC(=O)Cl.NC(=O)N(O)c1ccc(F)c(F)c1>>O=c1[nH]c(=O)n(-c2ccc(F)c(F)c2)o1,,[Na+],[OH-],O,,val
US20160108436A1,CCCCCC.CCCCCCCCCCC=O>>CCCC/C=C\CCCCCCCCCC,,Cc1ccccc1,,,,val
US20100286152A1,CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)C(C)(CO)C1>>CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)C(C)(C=O)C1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US07776875B2,CS(N)(=O)=O.Cc1ccc(F)cc1[C@@H]1NC(=O)C[C@H](c2cc(Cl)ccc2OC(C)(C)CO)[C@@]12C(=O)Nc1cc(Cl)ccc12>>Cc1ccc(F)cc1[C@@H]1NC(=O)C[C@H](c2cc(Cl)ccc2OC(C)(C)C(=O)NS(C)(=O)=O)[C@@]12C(=O)Nc1cc(Cl)ccc12,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20110237588A1,COC(=O)c1sccc1Cl.Cc1ccncc1>>O=C(Cc1ccncc1)c1sccc1Cl,,C1CCOC1,,[Li]CCCC,,val
US20060137207A1,COc1cc(C=CC(=O)c2ccc(I)cc2O)cc(OC)c1OC.OO>>COc1cc(-c2oc3cc(I)ccc3c(=O)c2O)cc(OC)c1OC,,CO,,[Na+].[OH-],,val
US06534546B1,BrC(Br)(Br)Br.Cc1cc(CO)ccc1NC(=O)OC(C)(C)C>>Cc1cc(CBr)ccc1NC(=O)OC(C)(C)C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060040961A1,CCN1CCNCC1.O=C(Cl)c1ccc(I)cc1>>CCN1CCN(C(=O)c2ccc(I)cc2)CC1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US04070539,CCC1Cc2cc(O)c(Cl)c(Cl)c2C1=O.CCOC(=O)CBr>>CCOC(=O)COc1cc2c(c(Cl)c1Cl)C(=O)C(CC)C2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040077859A1,CCOc1nc(N)nc(N)c1N=O>>CCOc1nc(N)nc(N)c1N,,O,,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20110105463A1,COC(=O)C1CCOc2cc(Oc3ccc(C(=O)O)cc3)c(C#N)cc21.NC1CC1c1ccccc1>>COC(=O)C1CCOc2cc(Oc3ccc(C(=O)NC4CC4c4ccccc4)cc3)c(C#N)cc21,,CN(C)C=O,ClCCl,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20050101623A1,O=CC(=O)O.c1ccc(COc2ccc3[nH]cc(C4CCNC4)c3c2)cc1>>O=C(O)C1c2[nH]c3ccc(OCc4ccccc4)cc3c2C2CCN1C2,,O,,,,val
US20090215759A1,C[Zn]C.Clc1cc(Cc2ccccc2)nc(Cl)n1>>Cc1cc(Cc2ccccc2)nc(Cl)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,CCOC(C)=O,O,val
US20040009968A1,C#C[Si](C)(C)C.CC(C)(C)OC(=O)n1nc(Br)c2cc([N+](=O)[O-])ccc21>>CC(C)(C)OC(=O)n1nc(C#C[Si](C)(C)C)c2cc([N+](=O)[O-])ccc21,I[Cu]I,CN(C)C=O,,CCN(CC)CC,,val
US20100261698A1,Cn1c(-c2cncc(NS(=O)(=O)CCOCc3ccccc3)c2)cc2ccccc21>>Cn1c(-c2cncc(NS(=O)(=O)CCO)c2)cc2ccccc21,[Pd],CO,,,,val
US20140256677A1,CC(=O)Cl.CCN(CC)CC.Nc1cc(-c2c(-c3ccccc3)nn3cccnc23)ccn1.O>>CC(=O)N(C(C)=O)c1cc(-c2c(-c3ccccc3)nn3cccnc23)ccn1,,C1CCOC1,,,,val
US20050233253A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=S(c1ccccc1)c1ccccc1.O=c1c2ccccc2sc2ccccc12>>O=S(=O)([O-])C(F)(F)F.O=c1c2ccccc2sc2ccc([S+](c3ccccc3)c3ccccc3)cc12,,ClCCl,,,,val
US04589910,CNC.O=C=Nc1ccc(Oc2ccc3sncc3c2)c(Cl)c1>>CN(C)C(=O)Nc1ccc(Oc2ccc3sncc3c2)c(Cl)c1,,CCOCC,,,,val
US06884868B1,CCCBr.OC1CCC(C2CCCCC2)CC1>>CCCC1CCC(C2CCC(O)CC2)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US20160229814A1,CC(CC(=O)O)CC(=O)Nc1ccc(C#N)c(Cl)c1.CCn1c(=O)c2cc(N)ccc2n(C[Si](C)(C)C)c1=O>>CCn1c(=O)c2cc(NC(=O)CC(C)CC(=O)Nc3ccc(C#N)c(Cl)c3)ccc2n(C[Si](C)(C)C)c1=O,,CCOC(C)=O,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20100234365A1,CCOC(=O)[C@H]1[C@H](c2ccccc2)N(c2ccc(Oc3ccc(Cl)cc3)cc2)C(=O)N1S(=O)(=O)c1ccc(C)cc1>>COC(=O)[C@@H]1NC(=O)N(c2ccc(Oc3ccc(Cl)cc3)cc2)[C@H]1c1ccccc1,,CO,,[Mg],,val
US20160200686A1,COc1ccc(C(C)(C)C(NC(=O)OC(C)(C)C)c2nc3ccccc3[nH]2)cc1.Cl.ClCCl>>COc1ccc(C(C)(C)C(N)c2nc3ccccc3[nH]2)cc1.Cl.Cl,,C1COCCO1,ClCCl,N#N,,val
US20100292225A1,CC1(C)OB(c2cncc(C=O)c2)OC1(C)C.N#Cc1ccc(Br)cc1Cl>>N#Cc1ccc(-c2cncc(C=O)c2)cc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20090035215A1,BrCCCOC1CCCCO1.Cc1cc(O)ccc1Br>>Cc1cc(OCCCOC2CCCCO2)ccc1Br,,CS(C)=O,ClCCl,O,[K+].[OH-],val
US20150005279A1,O=[N+]([O-])c1cc(OCc2nccs2)ccc1Br>>Nc1cc(OCc2nccs2)ccc1Br,[Fe],CCO,O,[Cl-].[NH4+],,val
US05167855,COc1ccc(C(=O)O)cc1>>O=C(O)c1ccc(O)cc1,,CC(=O)O,,Br,,val
US04524071,CCCCc1c[nH]c(=S)[nH]c1=O.CI>>CCCCc1cnc(SC)[nH]c1=O,,CCO,O,[Na+].[OH-],,val
US05049564,CCOC(=O)C(=O)OCC.CCOC(=O)CCc1cc(OC)ccc1Br>>CCOC(=O)C(=O)C(Cc1cc(OC)ccc1Br)C(=O)OCC,,CCOCC,,O,CC(C)(C)[O-].[K+],val
US20140329812A1,C#CN(C(=O)OC(C)(C)C)c1ccc(N2CCOCC2)cc1.CC(C)c1cc(N=[N+]=[N-])c(OCc2ccccc2)cc1OCc1ccccc1>>CC(C)c1cc(-n2nncc2N(C(=O)OC(C)(C)C)c2ccc(N3CCOCC3)cc2)c(OCc2ccccc2)cc1OCc1ccccc1,,CN(C)C=O,,CCOC(C)=O,O,val
US06756373B1,CCCc1c2nc(-c3cc(C#N)cnc3OCC(C)C)[nH]c(=O)c2nn1C.C[Si](C)(C)N=[N+]=[N-]>>CCCc1c2nc(-c3cc(-c4nnn[nH]4)cnc3OCC(C)C)[nH]c(=O)c2nn1C,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US20110021627A1,C#CC1=CCC(CC(C#N)(C#N)CCC(F)(F)F)CC1.O=C(OO)c1cccc(Cl)c1>>C#CC12CCC(CC(C#N)(C#N)CCC(F)(F)F)CC1O2,,ClC(Cl)Cl,,O=S([O-])[O-].[Na+].[Na+],,val
US20120316161A1,CCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc2sccc2c1>>CCCC(C(=O)O)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc2sccc2c1,,CO,O,[Na+].[OH-],,val
US20140088079A1,C=CCBr.C=Cc1c(C2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)cc(Cc2ccc(CC)cc2)c(Cl)c1O>>C=CCOc1c(Cl)c(Cc2ccc(CC)cc2)cc(C2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)c1C=C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050070587A1,CCCCC(=O)Cl.CCOC(=O)COc1ccc2cc(-c3cc4ccccc4s3)ccc2c1Cl>>CCCCC(=O)c1c(-c2ccc3c(Cl)c(OCC(=O)OCC)ccc3c2)sc2ccccc12,,ClC(Cl)Cl,,Cl[Sn](Cl)(Cl)Cl,,val
US20100137587A1,CCOC(=O)CN=[N+]=[N-].COc1ccccc1/C=C/C=O>>COC(=O)/C(=C/C=C/c1ccccc1OC)N=[N+]=[N-],,CO,,O,,val
US20010000177A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccc(C(=O)NNC(=O)c2cccc([N+](=O)[O-])c2)cc1>>Cc1ccc(-c2nnc(-c3cccc([N+](=O)[O-])c3)s2)cc1,,c1ccccc1,,,,val
US20010031777A1,COc1cccc(C=O)c1OCC=O>>COc1cccc2cc(C=O)oc12,,CC(=O)O,,,,val
US20040198833A1,CC(C)C(=O)Cl.CC(CNS(=O)(=O)C(C)C)c1ccc(C#CCCCCN)cc1>>CC(C)C(=O)NCCCCC#Cc1ccc(C(C)CNS(=O)(=O)C(C)C)cc1,,ClCCl,,CCN(CC)CC,,val
US20100099729A1,CC(C)(C)OC(=N)C(Cl)(Cl)Cl.O=C(N[C@@H](CO)C(=O)O)OCC1c2ccccc2-c2ccccc21>>CC(C)(C)OC(=O)C(CO)NC(=O)OCC1c2ccccc2-c2ccccc21,,C1CCCCC1,CCOC(C)=O,,,val
US20040176356A1,Cc1cccc(C)c1NC(=O)CN1CCN(CC(O)CNC(=O)OCc2ccccc2)CC1>>Cc1cccc(C)c1NC(=O)CN1CCN(CC(O)CN)CC1,,CO,,,,val
US20010051620A1,N#Cc1c[nH]c2cc3ccccc3cc2c1=O.O=P(Cl)(Cl)Cl>>N#Cc1cnc2cc3ccccc3cc2c1Cl,CN(C)C=O,,,,,val
US20090186879A1,CCOC(=O)CCCn1c(Nc2ccc(Cl)cc2)nc2c(Cl)ccc(C(CC)CC)c21>>CCC(CC)c1ccc(Cl)c2nc(Nc3ccc(Cl)cc3)n(CCCCO)c12,,C1CCOC1,,O,[BH4-].[Li+],val
US20130281708A1,COC(=O)c1cnc(N)s1.O=C(Cl)OCc1ccccc1>>COC(=O)c1cnc(NC(=O)OCc2ccccc2)s1,,CO,O,C1CCOC1,CCN(C(C)C)C(C)C,val
US20160096839A1,COc1cc(-c2c(-n3cc(C4CC4)nn3)ccc(Cl)c2F)ncn1>>Oc1cc(-c2c(-n3cc(C4CC4)nn3)ccc(Cl)c2F)ncn1,,CC(=O)O,,Br,,val
US20110144066A1,CC(C)(C)c1nnc(NS(=O)(=O)c2ccc(N)cc2)s1.CCCCCCCCCC(=O)Cl>>CCCCCCCCCC(=O)Nc1ccc(S(=O)(=O)Nc2nnc(C(C)(C)C)s2)cc1,,c1ccncc1,,Cl,,val
US20140045872A1,C[N+](=O)[O-].O=Cc1ccc(Cl)c(Cl)c1>>O=[N+]([O-])/C=C/c1ccc(Cl)c(Cl)c1,,CCO,,[Na+].[OH-],,val
US04329367,CC(N)Cc1ccc(OCc2ccccc2)cc1.O=C(CC(c1ccccc1)c1ccccc1)OC(=O)CC(c1ccccc1)c1ccccc1>>CC(Cc1ccc(OCc2ccccc2)cc1)NC(=O)CC(c1ccccc1)c1ccccc1,O=S(=O)(O)O,c1ccccc1,,,,val
US20060079697A1,O=[N+]([O-])c1cccc(Cl)c1Cl.Sc1ncc[nH]1>>O=[N+]([O-])c1cccc(Cl)c1Sc1ncc[nH]1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20010039344A1,COC(=O)C(CC1CCCC1)c1ccc(Cl)c([N+](=O)[O-])c1>>O=C(O)C(CC1CCCC1)c1ccc(Cl)c([N+](=O)[O-])c1,,C1CCOC1,,[Li+].[OH-],,val
US20120253035A1,CC1(C)COB(c2cc([C@@]3(C)NC(=O)COC(C)(C)C3(F)F)c(F)cc2F)OC1.Clc1ccc2oc(Cl)nc2c1>>CC1(C)OCC(=O)N[C@](C)(c2cc(-c3nc4cc(Cl)ccc4o3)c(F)cc2F)C1(F)F,[Pd],,,,,val
US20150152108A1,NC1CCOC1.O=C(O)c1ccc2c(n1)N(C(=O)Nc1ccccn1)[C@H]1CCN2C1>>O=C(NC1CCOC1)c1ccc2c(n1)N(C(=O)Nc1ccccn1)[C@H]1CCN2C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04563210,CCOC=C(C(=O)OCC)C(=O)C(F)(F)F.NNc1ccc(Cl)cc1Cl>>CCOC(=O)c1cnn(-c2ccc(Cl)cc2Cl)c1C(F)(F)F,,CCO,,CCN(CC)CC,Cl,val
US05075301,CS(=O)(=O)Cl.O=C(c1ccc(CN2CCC(O)CC2)o1)N1CCCCC1>>CS(=O)(=O)OC1CCN(Cc2ccc(C(=O)N3CCCCC3)o2)CC1,,c1ccncc1,,CO,,val
US20020016322A1,CCOC(=O)C(F)(F)F.NCCNCCO>>O=C(NCCNCCO)C(F)(F)F,,CCOCC,,,,val
US20130109679A1,CCOC(=O)c1ccc2cc3n(c2c1)CC1(CC1)CNC3=O>>O=C(O)c1ccc2cc3n(c2c1)CC1(CC1)CNC3=O,,CCO,O,CC(=O)O,[Na+].[OH-],val
US20060128790A1,COc1cc2c(c(C)c1C)NCC1(CCC1)C2=O>>COc1cc2c(c(C)c1C)NCC1(CCC1)C2O,,C1CCOC1,CO,[BH4-].[Na+],,val
US20140206681A1,CC1(C)OB(c2ccc(C(=O)O)cc2)OC1(C)C.Nc1cc2ccccc2cn1>>CC1(C)OB(c2ccc(C(=O)Nc3cc4ccccc4cn3)cc2)OC1(C)C,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20010027196A1,COCCN.CS(=O)c1nc(N)nc(-c2ccco2)c1Cl>>COCCNc1nc(N)nc(-c2ccco2)c1Cl,,COCCOC,,,,val
US20100273739A1,CC(C)(C)OC(=O)NC1CCc2ccc(CN)cc2C1Cc1ccc(Cl)c(Cl)c1.CCCS(=O)(=O)Cl>>CCCS(=O)(=O)NCc1ccc2c(c1)C(Cc1ccc(Cl)c(Cl)c1)C(NC(=O)OC(C)(C)C)CC2,CN(C)c1ccncc1,ClCCl,,,,val
US05817678,CCOC(=O)[C@H]1CCCN(CC(O)(c2ccccc2)c2ccccn2)C1>>O=C(O)[C@H]1CCCN(CC(O)(c2ccccc2)c2ccccn2)C1,,CCO,,O,[Na+].[OH-],val
US20100234378A1,C#CC(C)(C)NS(=O)(=O)c1ccc(I)cc1.CC(C)Oc1ccc(B(O)O)cc1>>C#CC(C)(C)NS(=O)(=O)c1ccc(-c2ccc(OC(C)C)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20150111857A1,CCOC(=O)C(=O)c1ccc([N+](=O)[O-])cc1>>O=[N+]([O-])c1ccc(C(O)CO)cc1,,CCO,,[BH4-].[Na+],,val
US05037819,CC(=O)OC1C(CCCNC(=NC(=O)OCc2ccccc2)NC(=O)OCc2ccccc2)C(=O)N1C(C)=O.Cl>>CC(=O)OC1C(CCCNC(=N)N)C(=O)N1C(C)=O.Cl,[Pd],CCOC(C)=O,CO,[H][H],,val
US20050032786A1,COC(=O)c1ccccc1S.N#Cc1cccc(-n2cccn2)n1>>O=c1nc(-c2cccc(-n3cccn3)n2)sc2ccccc12,,Cc1ccccc1,,CCN(CC)CC,,val
US20030203966A1,Cc1cc(N)cc(C)c1S(=O)(=O)C[N+](=O)[O-].Cc1ccccc1S(=O)(=O)N=C=O>>Cc1ccccc1S(=O)(=O)NC(=O)Nc1cc(C)c(S(=O)(=O)C[N+](=O)[O-])c(C)c1,,ClCCl,,,,val
US20100298287A1,Br[Mg]C1CC1.O=Cc1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1C(F)(F)F>>OC(c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1C(F)(F)F)C1CC1,,C1CCOC1,,,,val
US20140094462A1,C=CCCC(=O)N[C@@H]1c2ccccc2C[C@H]1O.C=CC[C@@H](C)C(=O)O>>C=CCCC(=O)N[C@@H]1c2ccccc2C[C@H]1OC(=O)[C@H](C)CC=C,,CN(C)C=O,,CCCCCC,CCOC(C)=O,val
US20150218124A1,CCc1ccc(C=O)cc1.N#Cc1cc(O)c(O)c(C#N)c1N>>CCc1ccc(/C=N/c2c(C#N)cc(O)c(O)c2C#N)cc1,,CCO,,,,val
US20050038076A1,NC(=O)COc1ccccc1OCC(N)=O.O=S(=O)(O)Cl>>NC(=O)COc1ccc(S(=O)(=O)Cl)cc1OCC(N)=O,,O,,ClCCl,,val
US20100022535A1,Cc1cccc(-c2[nH]c(Cc3ccc(F)c([N+](=O)[O-])c3)nc2-c2ccc3ncccc3c2)n1>>Cc1cccc(-c2[nH]c(Cc3ccc(F)c(N)c3)nc2-c2ccc3ncccc3c2)n1,[Pd],CO,,O=C[O-].[NH4+],,val
US20090074738A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.OCCc1ccc(Br)cc1>>CC(C)(C)[Si](OCCc1ccc(Br)cc1)(c1ccccc1)c1ccccc1,,CN(C)C=O,,O,c1c[nH]cn1,val
US20090163499A1,CCc1ncc[nH]1.COC(=O)c1cc(I)cc(-c2ccc(C)cc2)c1>>CCc1nccn1-c1cc(C(=O)OC)cc(-c2ccc(C)cc2)c1,[Cu]I,CS(C)=O,,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US20090253740A1,CC(=O)c1ccc2[nH]ncc2c1.NO>>CC(=NO)c1ccc2[nH]ncc2c1,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20160137649A1,CON(C)C(=O)c1cc(C(C)C)nn1C1CCCCC1>>CC(C)c1cc(C=O)n(C2CCCCC2)n1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20090258867A1,N#CC1(NC(=O)c2cnn3c(-c4ccc(Cl)cc4)c(-c4ccccc4Cl)cnc23)CCCCC1.[N-]=[N+]=[N-]>>O=C(NC1(c2nnn[nH]2)CCCCC1)c1cnn2c(-c3ccc(Cl)cc3)c(-c3ccccc3Cl)cnc12,,CN(C)C=O,Cc1ccccc1,CCN(CC)CC,Cl,val
US20100292212A1,CN.O=C1N(c2ccc(OC(F)(F)F)cc2)CCC12CCN(S(=O)(=O)c1cccnc1Cl)CC2>>CNc1ncccc1S(=O)(=O)N1CCC2(CCN(c3ccc(OC(F)(F)F)cc3)C2=O)CC1,,CCOC(C)=O,,CCO,,val
US04775677,CCCCCCCCNC(=S)NCCCCCCCC.O=C(O)C#CC(=O)O>>CCCCCCCCN=C1SC(=CC(=O)O)C(=O)N1CCCCCCCC,,CO,,,,val
US20150344429A1,CCOC(=O)C(C)c1noc(C)n1.NOP(=O)(c1ccccc1)c1ccccc1>>CCOC(=O)C(C)(N)c1noc(C)n1,,CN(C)C=O,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20100004235A1,CC(C)COC(=O)Cl.NC(=NO)c1nn(Cc2cc(F)ccc2F)c2ncccc12>>O=c1[nH]c(-c2nn(Cc3cc(F)ccc3F)c3ncccc23)no1,,CN(C)C=O,,O,c1ccncc1,val
US20120115882A1,Cc1cccc(NCC2CC3(CCCC3)CCN2C(=O)OC(C)(C)C)n1>>Cc1cccc(NCC2CC3(CCCC3)CCN2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05298527,BrB(Br)Br.CC=C(C(=O)OC)c1ccccc1COC>>CC=C(C(=O)OC)c1ccccc1CBr,,ClCCl,,CO,O,val
US20030096841A1,NCc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O.O=C(Cl)C1CC1>>O=C1CCC(N2Cc3c(CNC(=O)C4CC4)cccc3C2=O)C(=O)N1,,CC#N,,C1CCC2=NCCCN2CC1,Cl,val
US20080004302A1,Clc1ccnc(NCc2cc(C3CC3)no2)n1.Nc1cc(C2CCCC2)n[nH]1>>c1cc(Nc2cc(C3CCCC3)n[nH]2)nc(NCc2cc(C3CC3)no2)n1,,CCO,,,,val
US20090042929A1,N=C(Cc1cccs1)NO.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>c1csc(Cc2noc(C34CC5CC(CC(C5)C3)C4)n2)c1,,Cc1ccccc1,,c1ccncc1,,val
US06432982B1,COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(O)c(F)c2)cc1.ClCCN1CCCCC1>>COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)c(F)c2)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20090162307A1,CC(C)c1cc(C(=O)CCl)cc(C(C)C)c1O.Cc1ccc([O-])cc1>>Cc1ccc(OCC(=O)c2cc(C(C)C)c(O)c(C(C)C)c2)cc1,,CN(C)C=O,,Cl,,val
US06881736B1,C=CC(=O)Cl.CC1C(c2ccccc2)NC(=O)N1C>>C=CC(=O)N1C(=O)N(C)C(C)C1c1ccccc1,Cl[Cu],ClCCl,,CCN(C(C)C)C(C)C,,val
US06461997B1,CCN(CC)C(=O)n1cnc(S(=O)(=O)C(F)(F)Br)n1>>O=S(=O)(c1nc[nH]n1)C(F)(F)Br,,CO,,C[O-].[Na+],,val
US05252575,CCOCCCl.OCCCO>>CCOCOCCCO,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US05374772,COC(=O)c1ccccc1OCCOc1cccc2ccccc12>>O=C(O)c1ccccc1OCCOc1cccc2ccccc12,,C1COCCO1,CO,[Na+].[OH-],,val
US20110172233A1,C=CCCC(=O)O[C@@H](CNC(=O)[C@@H](CC=C)CC(=O)OC(C)(C)C)c1ccccc1>>CC(C)(C)OC(=O)C[C@@H]1CC=CCCC(=O)O[C@H](c2ccccc2)CNC1=O,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,Cc1ccccc1,ClCCl,,,val
US04383945,CC(C)=O.O=C(Cl)OCc1ccccc1.[C-]#[N+][C@H]1C(=O)N(C(C(=O)OC)=C(C)C)[C@@H]1CC=C>>[C-]#[N+][C@]1(C(C)(C)OC(=O)OCc2ccccc2)C(=O)N(C(C(=O)OC)=C(C)C)[C@@H]1CC=C,,C1CCOC1,CC(=O)O,[Li]CCCC,,val
US20100093730A1,O=C(O)CN1CCCC(c2ccccc2)(c2ccccc2)C1=O.[H]/N=C(\NO)c1ccc(C(F)(F)F)nc1>>O=C1N(Cc2nc(-c3ccc(C(F)(F)F)nc3)no2)CCCC1(c1ccccc1)c1ccccc1,,CC(Cl)Cl,,CCN=C=NCCCN(C)C,Cl,val
US20030008849A1,CCOC(=O)C1CN(C)CCN1S(=O)(=O)c1ccc(F)cc1>>CN1CCN(S(=O)(=O)c2ccc(F)cc2)C(C(=O)O)C1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20030092677A1,CCOC(C)=N.NNC(=O)c1cccc(C2=Nc3ccc(-c4ccc(F)cc4)cc3NC(=O)C2)c1>>Cc1nnc(-c2cccc(C3=Nc4ccc(-c5ccc(F)cc5)cc4NC(=O)C3)c2)o1,,O,c1ccncc1,Cl,,val
US05849735,CCOC(=O)CCCNc1ccccc1C(=O)OC.Cc1ccccc1S(=O)(=O)Cl>>CCOC(=O)CCCN(c1ccccc1C(=O)OC)S(=O)(=O)c1ccccc1C,,c1ccncc1,,,,val
US20160244444A1,Cn1nccc1CCOS(C)(=O)=O.[N-]=[N+]=[N-]>>Cn1nccc1CCN,,CN(C)C=O,,O,,val
US20100240702A1,CCOC(=O)C[C@H](CCc1ccccc1)n1c(=O)[nH]c2ccc(C)cc21.Cc1cccc2scc(CO)c12>>CCOC(=O)C[C@H](CCc1ccccc1)n1c(=O)n(Cc2csc3cccc(C)c23)c2ccc(C)cc21,,CCOC(C)=O,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100069367A1,Nc1ccc(Br)cc1.O=C(Cl)c1cc(C(F)(F)F)nn1-c1ccccc1Cl>>O=C(Nc1ccc(Br)cc1)c1cc(C(F)(F)F)nn1-c1ccccc1Cl,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060089367A1,CC(C)(C)OC(=O)N1CCN(c2cc3c(cc2F)nc(COc2ccccc2)n3Cc2ccc(Cl)cc2)CC1>>O=C(C1CC1)N1CCN(c2cc3c(cc2F)nc(COc2ccccc2)n3Cc2ccc(Cl)cc2)CC1,,O,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20120010190A1,COC(=O)CCCBr.Cc1cc(Cl)ccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(O)c(F)c1>>COC(=O)CCCOc1ccc(C(CC(=O)c2ccc(=O)n(C)c2)c2ccc(Cl)cc2C)cc1F,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030069297A1,Cc1cc(C(=O)NCCN2CCCC2)c(C=O)[nH]1.O=C1Cc2c(cccc2-c2ccc(OC(F)(F)F)cc2)N1>>Cc1cc(C(=O)NCCN2CCCC2)c(C=C2C(=O)Nc3cccc(-c4ccc(OC(F)(F)F)cc4)c32)[nH]1,C1CCNCC1,CCO,,,,val
US20100160397A1,CCOC(=O)C(=O)CBr.NC(=O)Nc1cc(F)c(F)cc1F>>CCOC(=O)c1coc(Nc2cc(F)c(F)cc2F)n1,,CN1CCCC1=O,,O,,val
US04570007,CC1(C)OCC(C(O)CN=[N+]=[N-])O1>>CC1(C)OCC(C(O)CN)O1,[Pd],CO,,,,val
US20030064962A1,CC(C)(C)OC(=O)C[C@@]1(C)C[C@@H](C(=O)Nc2ccccc2)n2c1ncc(NCc1cccc(C(F)(F)F)c1)c2=O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)C[C@@]1(C)C[C@@H](C(=O)N(C(=O)OC(C)(C)C)c2ccccc2)n2c1ncc(NCc1cccc(C(F)(F)F)c1)c2=O,CN(C)c1ccncc1,CC#N,CCOC(C)=O,,,val
US20130116235A1,Cn1nc(-c2ccnc(N3CCn4c5c(c(F)c4C3=O)CCCC5)c2C=O)cc(Nc2ccncn2)c1=O>>Cn1nc(-c2ccnc(N3CCn4c5c(c(F)c4C3=O)CCCC5)c2CO)cc(Nc2ccncn2)c1=O,,O,,CO,[BH4-].[Na+],val
US20150368231A1,Cc1ccc(N)nc1.O=C1OC(=O)c2cc(Br)ccc21>>Cc1ccc(NC(=O)c2ccc(Br)cc2C(=O)O)nc1,,CC(C)=O,,,,val
US20140142083A1,CC(C)(C)OC(=O)N1CCCCC1=O.COC(=O)c1cc(Cl)cc(N)c1C>>COC(=O)c1cc(Cl)cc(NC2CCN(C(=O)OC(C)(C)C)CC2)c1C,,ClCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US05824802,CCC1CN(c2c(S(C)(=O)=O)ccc(C(=O)c3cnn(CC)c3O)c2Cl)CC(O)O1.CO>>CCC1CN(c2c(S(C)(=O)=O)ccc(C(=O)c3cnn(CC)c3O)c2Cl)CC(OC)O1,,CO,ClCCl,CC(=O)Cl,,val
US20070299051A1,COC(=O)c1cc(C)c2c(c1)S(=O)(=O)Cc1cc(N(CCCl)C(=O)CCl)cc(Cl)c1O2.NC1CC1>>COC(=O)c1cc(C)c2c(c1)S(=O)(=O)Cc1cc(N3CCN(C4CC4)CC3=O)cc(Cl)c1O2,,CN(C)C=O,,,,val
US04291047,CC(C)(C)C(=O)CCl.c1nc[nH]n1>>CC(C)(C)C(=O)Cn1cncn1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080003290A1,CC1(C)OCc2cc([C@@H]3CN(CCCCCCOCCOCc4cccc(N)c4)C(=O)O3)ccc2O1.O=C=Nc1cccc(I)c1>>CC1(C)OCc2cc([C@@H]3CN(CCCCCCOCCOCc4cccc(NC(=O)Nc5cccc(I)c5)c4)C(=O)O3)ccc2O1,,ClCCl,,CC(C)O,,val
US20050267149A1,COC(=O)c1ccccc1COc1ccc(CCO)cc1.CS(=O)(=O)Cl>>COC(=O)c1ccccc1COc1ccc(CCOS(C)(=O)=O)cc1,,ClCCl,,CCN(CC)CC,,val
US20120208796A1,CNC(=O)c1cc(Br)ccc1C.N#Cc1cccc(Cl)c1>>O=c1[nH]c(-c2cccc(Cl)c2)cc2ccc(Br)cc12,,C1CCOC1,C1CCOC1,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20120129902A1,CC(C)(C)OC(=O)N[C@]1(C(=O)OC(C)(C)C)[C@H]2[C@@H](C(=O)[C@H]1CSc1ccc(F)c(F)c1)[C@@H]2C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@]1(C(=O)OC(C)(C)C)[C@H]2[C@H]([C@@H]2C(=O)OC(C)(C)C)[C@H](O)[C@H]1CSc1ccc(F)c(F)c1,,CCOCC,CCOCC,B,CSC,val
US20110312936A1,CCC(N)C1CCC2(CC1)OCCO2.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCC(NS(=O)(=O)C(F)(F)F)C1CCC2(CC1)OCCO2,,ClCCl,,Cl,,val
US20110039843A1,BrC1CCCC1.Oc1cnccc1-c1nc2cc(C(F)(F)F)ccc2o1>>FC(F)(F)c1ccc2oc(-c3ccncc3OC3CCCC3)nc2c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150315198A1,O=S(Cl)Cl.OCc1ccc(CC2CCOC2)nc1>>ClCc1ccc(CC2CCOC2)nc1,,ClCCl,,,,val
US20060167009A1,CC(C)(C)OC(=O)N1CCN(c2ncc(C=O)s2)CC1.FC(F)(Br)Br>>CC(C)(C)OC(=O)N1CCN(c2ncc(C=C(F)F)s2)CC1,[Zn],CN(C)C=O,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20020103253A1,COC(=O)c1sc(C(C)(C)C)cc1NC(=O)Nc1ccccc1[N+](=O)[O-]>>COC(=O)c1sc(C(C)(C)C)cc1NC(=O)Nc1ccccc1N,[Pd],CO,,,,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(Cl)c(OCCOC)cc1CC2C(C)C>>COCCOc1cc2c(cc1Cl)-c1cc(=O)c(C(=O)O)cn1C(C(C)C)C2,,CO,O,Cl,[Li+].[OH-],val
US20130274244A1,CCO.O=C(O)c1cccc(Cl)n1>>CCOC(=O)c1cccc(Cl)n1,,Cc1ccccc1,,O=S(=O)(O)O,,val
US20050059702A1,C=CCBr.Cc1cccnc1C1CCCC(c2ncccc2C)N1CCc1cnc[nH]1>>C=CCn1cnc(CCN2C(c3ncccc3C)CCCC2c2ncccc2C)c1,,C1CCOC1,,[H-].[Na+],,val
US20050085470A1,CC1(C)OC(=O)Nc2ccc(OS(=O)(=O)c3cccc(Cl)c3Cl)cc21.CI>>CN1C(=O)OC(C)(C)c2cc(OS(=O)(=O)c3cccc(Cl)c3Cl)ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060014777A1,CCc1cc(C)c2c(c1)[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1NC2=O.COC(=O)CBr>>CCc1cc(C)c2c(c1)[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1N(CC(=O)OC)C2=O,,C1CCOC1,,[H-].[Na+],,val
US20140018319A1,CN(C)C=O.CN1C(C)(C)CC(O)CC1(C)C.N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(F)cc1F>>CN1C(C)(C)CC(Oc2cc(F)c(C#N)cc2Nc2nc(NC3CC3)c3ncc(C#N)n3n2)CC1(C)C.N,,CN(C)C=O,,[H-].[Na+],,val
US20080015222A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.COC(=O)Cn1cnc2cccc(Br)c21>>COC(=O)Cn1cnc2cccc(-c3ccccn3)c21,O=[Cu],CN(C)C=O,,,,val
US20090069368A1,COC(=O)c1cc(C(=O)c2c(C)c(OCc3cccc(OCC(=O)OC(C)(C)C)c3)c3ccccn23)ccc1N>>COC(=O)c1cc(C(=O)c2c(C)c(OCc3cccc(OCC(=O)O)c3)c3ccccn23)ccc1N,,ClCCl,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],,val
US20120101079A1,C1COCCN1.COC(=O)c1c(C)cc(Cl)nc1OC>>COC(=O)c1c(C)cc(N2CCOCC2)nc1OC,,CN1CCCC1=O,,CCN(CC)CC,CCOC(C)=O,val
US20100075948A1,COC(=O)c1cccc(CNC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(c3ccc(Cl)cc3F)[C@H]2c2cccc(Cl)c2F)c1>>CC(C)(C)C[C@@H]1N[C@@H](C(=O)NCc2cccc(C(=O)O)c2)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F,,CO,,[Na+].[OH-],,val
US20110009405A1,COS(=O)(=O)OC.O=[N+]([O-])c1cn[nH]c1>>Cn1cc([N+](=O)[O-])cn1,,[Na+],[OH-],,,val
US20160052897A1,CC(C)[Si](c1ncc(B2OC(C)(C)C(C)(C)O2)o1)(C(C)C)C(C)C.O=C(N1CCc2c(Br)cc(C(F)(F)F)cc21)N1CC2CC1CO2>>FC(F)(F)c1cc(-c2cnco2)nc(N2C[C@@H]3C[C@H]2CO3)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20070111998A1,O=C(O)c1ccc([N+](=O)[O-])o1.OC(CNC1CCNCC1)COc1cccc2[nH]c3ccccc3c12>>O=C(c1ccc([N+](=O)[O-])o1)N1CCC(NCC(O)COc2cccc3[nH]c4ccccc4c23)CC1,,CN(C)C=O,ClCCl,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20060287386A1,COC(=O)c1cc(C)ccc1S.O=C1CCC(=O)N1Cl>>COC(=O)c1ccc(Cl)cc1S,,ClCCCl,,,,val
US20110039874A1,CO.O=S(=O)(Cl)CCCCCCCc1ccc(OCc2ccccc2)cc1>>COS(=O)(=O)CCCCCCCc1ccc(OCc2ccccc2)cc1,,CCOCC,,,,val
US20020143034A1,COC(=O)c1ccc(Oc2ccc(C[C@@H](CO)NC[C@H](O)c3cccc(Cl)c3)cc2)nc1.Cl.Cl>>Cl.Cl.O=C(O)c1ccc(Oc2ccc(C[C@@H](CO)NC[C@H](O)c3cccc(Cl)c3)cc2)nc1,,CO,,Cl,[Na+].[OH-],val
US20110294854A1,O[C@@H]1CC[C@@H]2CN(c3cccc(C(F)(F)F)n3)C[C@H]12.Oc1cccc(F)c1>>Fc1cccc(O[C@H]2CC[C@@H]3CN(c4cccc(C(F)(F)F)n4)C[C@H]23)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070244103A1,CCCN.COc1ccc2nccc(Cl)c2c1>>COc1ccc2nccc(N)c2c1,,c1ccncc1,,Cl,,val
US05648352,CC1(C)C2CCC1(CS(=O)(=O)Cl)C(=O)C2.Cc1ccccc1N1CCN(C(=O)OC(C)(C)C)CC1=O>>Cc1ccccc1N1CCN(S(=O)(=O)CC23CCC(CC2=O)C3(C)C)CC1=O,,ClC(Cl)Cl,ClCCl,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20030083357A1,COc1cc(O)c(C=O)cc1Br.Cc1cc2c(cc1B(O)O)C(C)(C)CCC2(C)C>>COc1cc(O)c(C=O)cc1-c1cc2c(cc1C)C(C)(C)CCC2(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[K+].[K+],val
US06610692B1,C=C[Sn](CCCC)(CCCC)CCCC.O=[N+]([O-])c1cccnc1Cl>>C=Cc1ncccc1[N+](=O)[O-],Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,[Cl-].[Li+],,val
US05336778,CC(C)(C)OC(=O)c1ccccc1-c1ccc(CN)cc1.CI.S=C=S>>CSC(=S)NCc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1,,CO,,CCN(CC)CC,,val
US20040006245A1,CCc1ccc(Nc2c(C(=O)NOC3COC(C)(C)OC3)ccc(F)c2F)c(F)c1>>CCc1ccc(Nc2c(C(=O)NOC(CO)CO)ccc(F)c2F)c(F)c1,,CCO,,Cl,,val
US20150218093A1,COc1cc([N+](=O)[O-])ccc1O.OCCSC(c1ccccc1)(c1ccccc1)c1ccccc1>>COc1cc([N+](=O)[O-])ccc1OCCSC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,CCOC(C)=O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20010051620A1,COc1cc(Nc2c(C#N)cnc3c2sc2ccc([N+](=O)[O-])cc23)c(C)cc1Cl>>COc1cc(Nc2c(C#N)cnc3c2sc2ccc(N)cc23)c(C)cc1Cl,[Fe],CO,,[Cl-].[NH4+],,val
US20140275030A1,N#CC1(c2ccccn2)COc2cccc([N+](=O)[O-])c2N1>>NCC1(c2ccccn2)COc2cccc([N+](=O)[O-])c2N1,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US06143779,Cc1cc(C=O)ccc1O.O=C1COc2cc(O)ccc21>>Cc1cc(C=C2Oc3cc(O)ccc3C2=O)ccc1O,,CO,,Cl,O,val
US20040058965A1,C1CCOC1.Cc1ccc(OCc2nc(-c3ccccc3)oc2C)cn1.O=C(OO)c1cccc(Cl)c1>>CC(=O)OCc1ccc(OCc2nc(-c3ccccc3)oc2C)cn1,,C1CCOC1,,,,val
US20140309185A1,CC(C)(C)OC(=O)CBr.Sc1n[nH]c(-c2cccc(Br)c2)n1>>O=C(O)CSc1n[nH]c(-c2cccc(Br)c2)n1,,CC(C)=O,,,,val
US20040010007A1,CCCCc1nc2c(Cl)nc(C)c(C)c2n1CCOc1ccccc1.Oc1ccccc1>>CCCCc1nc2c(Oc3ccccc3)nc(C)c(C)c2n1CCOc1ccccc1,,COCCOCCOC,,[H][H],[H-].[Na+],val
US20090233879A1,CC(=O)OC1(C)[C@@H](COC(=O)c2ccccc2)OC(n2cnc3c(NC4CCCCC4)ncnc32)[C@]1(C)F>>CC1(O)[C@@H](CO)OC(n2cnc3c(NC4CCCCC4)ncnc32)[C@]1(C)F,,N,,CO,,val
US06288261B1,O=C(OCc1ccccc1)c1c(CCCOC2=CCCCO2)ccc2ccccc12>>O=C(OCc1ccccc1)c1c(CCCO)ccc2ccccc12,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140094465A1,Brc1csc(Br)n1.OB(O)c1ccc(O)cc1>>Oc1ccc(-c2nc(Br)cs2)cc1,,O,,,,val
US06008230,CCc1cnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1CCO.O=C1CCC(=O)N1Br>>CCc1cnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1CCBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100310500A1,CC(C)(Br)C(=O)OCc1ccccc1.FC(F)(F)c1ccc(N2CCNCC2)nc1>>CC(C)(C(=O)OCc1ccccc1)N1CCN(c2ccc(C(F)(F)F)cn2)CC1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US05578636,CC(C)CC(=O)Cl.OCCC#Cc1ccc(-c2cccs2)s1>>CC(C)CC(=O)OCCC#Cc1ccc(-c2cccs2)s1,,c1ccncc1,,,,val
US05387610,C1CCOC1.CC(C)COC(=O)Cl.CCN(CC)CC>>CCCCCC.CCOC(C)=O,,ClC(Cl)Cl,,N,,val
US20080234255A1,CC(C)N(CCC(=O)OC(C)(C)C)c1nc(Cl)ncc1[N+](=O)[O-]>>CC(C)N(CCC(=O)OC(C)(C)C)c1nc(Cl)ncc1N,[Pd],CCOC(C)=O,,[H][H],,val
US20090149425A1,CC(C)(C)n1cc(CO)cn1.ClCCl.O=S(Cl)Cl>>CC(C)(C)n1cc(CCl)cn1.Cl,,ClCCl,,,,val
US20060199829A1,COC(=O)c1cnc(N2CCc3[nH]c4cc(Br)ccc4c3C2)nc1.O=Cc1cccc(B(O)O)c1>>COC(=O)c1cnc(N2CCc3[nH]c4cc(-c5cccc(C=O)c5)ccc4c3C2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120220779A1,CCOc1ccc(-c2ccc(CO)cc2)cn1.Clc1nc(Cl)nc(Cl)n1>>CCOc1ccc(-c2ccc(CCl)cc2)cn1,,C1CCOC1,,CS(C)=O,,val
US05364896,C[Si](C)(C)O.Cl[Si](Cl)(c1ccccc1)c1ccccc1>>C[Si](C)(C)O[Si](Cl)(c1ccccc1)c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20120264734A1,Cc1cc(C)c(CNC(=O)c2cc(Br)cc(N(C)C3CCCC3)c2C)c(=O)[nH]1.Cn1cc(B(O)O)cn1>>Cc1cc(C)c(CNC(=O)c2cc(-c3cnn(C)c3)cc(N(C)C3CCCC3)c2C)c(=O)[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20080119468A1,Cc1ccc(N)cc1-c1ccc2c(O[C@H](C)C(F)(F)F)nncc2c1.[I-]>>Cc1ccc(I)cc1-c1ccc2c(O[C@H](C)C(F)(F)F)nncc2c1,,Cl,O,O=N[O-].[Na+],,val
US20090124605A1,CN1CCN(c2ccc([N+](=O)[O-])cc2CO)CC1.CO>>COC(=O)c1cc([N+](=O)[O-])ccc1N1CCN(C)CC1,[Fe],,,O,[Cl-].[NH4+],val
US03947520,COc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCC2CO2)cc1.O=C1CCC(=O)N1>>COc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCC(O)CN2C(=O)CCC2=O)cc1,C1CCNCC1,CCO,,,,val
US07491737B2,CC(C)C1(C(=O)Cl)CCC(=O)C1.NCc1cc(F)cc(C(F)(F)F)c1>>CCC(=O)CC(Cc1cc(F)cc(C(F)(F)F)c1)(C(N)=O)C(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020019436A1,CCN(CC)CC(=O)c1c[nH]c(C(=O)c2ccccc2Cl)c1.CSCCCl>>CCSCn1cc(C(=O)CN(CC)CC)cc1C(=O)c1ccccc1Cl,,CCCCCC,CN(C)C=O,O,[H-].[Na+],val
US05399695,CN(C)c1ccccc1.COc1ccc(CO)cc1.F[Sb-](F)(F)(F)(F)F>>COc1ccc(C[N+](C)(C)c2ccccc2)cc1.F[Sb-](F)(F)(F)(F)F,,C[N+](=O)[O-],,O=S(=O)([O-])[O-].[Mg+2],,val
US20090047244A1,CC(C)c1cc[nH]n1.COc1ccc(COc2cc(Cl)nc3c(Cl)c(OC)ccc23)cc1>>COc1ccc2c(O)cc(-n3ccc(C(C)C)n3)nc2c1Cl,,CN1CCCC1=O,,O,,val
US20080261941A1,Cc1cccc(Oc2cccc(CO)c2)n1.O=S(Cl)Cl>>Cc1cccc(Oc2cccc(CCl)c2)n1,,ClCCl,,O=C([O-])O.[Na+],,val
US20100317657A1,Cc1nn(C)cc1Nc1c([N+](=O)[O-])cnc2ccc(Br)cc12>>Cc1nn(C)cc1Nc1c(N)cnc2ccc(Br)cc12,[Ni],C1CCOC1,CO,,,val
US20150291636A1,COP(=O)(/C=C/[C@@H](OCc1ccccc1)[C@H](OCc1ccccc1)[C@@H](CN(C=O)OCc1ccccc1)OCc1ccccc1)OC>>COP(=O)(CC[C@@H](OCc1ccccc1)[C@H](OCc1ccccc1)[C@@H](CN(C=O)OCc1ccccc1)OCc1ccccc1)OC,[Pt],CCOC(C)=O,,,,val
US20040106650A1,CN.O=C(O)C1CC(=O)N(c2ccc(/C=C/c3cccc(F)c3)cc2)C1>>CNC(=O)C1CC(=O)N(c2ccc(/C=C/c3cccc(F)c3)cc2)C1,,CCO,ClCCl,O,O=S(Cl)Cl,val
US20160046618A1,CCOC(=O)[C@]12C[C@H]1[C@@](C)(c1cc(Nc3nccc4cc(Cl)cnc34)cc(F)c1F)N=C(N)S2>>C[C@]1(c2cc(Nc3nccc4cc(Cl)cnc34)cc(F)c2F)N=C(N)S[C@@]2(CO)C[C@H]21,,C1CCOC1,,CO,[BH4-].[Li+],val
US20160264575A1,CC(C)(C)OC(=O)CCN1C(=O)N2Cc3c(c4ccccc4n3Cc3ccc(F)cc3)C[C@H]2C1=S>>O=C(O)CCN1C(=O)N2Cc3c(c4ccccc4n3Cc3ccc(F)cc3)C[C@H]2C1=S,,CCOC(C)=O,,,,val
US20120088755A1,O=C(Nc1c(Cl)cc(O)cc1[N+](=O)[O-])C1CCOC1>>Nc1cc(O)cc(Cl)c1NC(=O)C1CCOC1,[Ni],CCOC(C)=O,,[H][H],,val
US20150291655A1,CS(=O)(=O)Cl.O=S1(=O)CCC(CCO)CC1>>CS(=O)(=O)OCCC1CCS(=O)(=O)CC1,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US20060142575A1,CN(C)CCCl.N#Cc1nc(NC2CCCC2)c2cc(O)ccc2n1>>CN(C)CCOc1ccc2nc(C#N)nc(NC3CCCC3)c2c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20060003944A1,CCOC(=O)CN=C(c1ccccc1)c1ccccc1.Fc1cc(CBr)cc(F)c1F>>CCOC(=O)C(Cc1cc(F)c(F)c(F)c1)N=C(c1ccccc1)c1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140213554A1,CC(C)(C)OC(=O)Nc1cnc2[nH]c(-n3cccn3)cc2c1.Cl>>Cl.Nc1cnc2[nH]c(-n3cccn3)cc2c1,,C1COCCO1,ClCCl,,,val
US09273057B2,CC(C)(C)OC(=O)Nc1cc(C#N)cc(CCC(=O)CO)c1Cl.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCC(O)CCc2cc(C#N)cc(NC(=O)OC(C)(C)C)c2Cl)cc1,,ClCCl,,CO,[BH4-].[Na+],val
US20110065706A1,CC1(O)COC1.O=C(Cl)Oc1ccc(F)cc1>>CC1(OC(=O)Oc2ccc(F)cc2)COC1,,ClCCl,,,,val
US20050197338A1,NC(=O)Nc1cn(-c2ccc(I)c(Cl)c2)nc1C(N)=O.OB(O)c1cccc(O)c1>>NC(=O)Nc1cn(-c2ccc(-c3cccc(O)c3)c(Cl)c2)nc1C(N)=O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050085482A1,COc1ccc([N+](=O)[O-])c(C=O)c1.OCCO>>COc1ccc([N+](=O)[O-])c(C2OCCO2)c1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20110294807A1,CCC(C)c1ccc(-n2c(-c3ccc(OCCO[Si](C)(C)C(C)(C)C)c(C)c3)nc3ccccc3c2=O)cc1>>CCC(C)c1ccc(-n2c(-c3ccc(OCCO)c(C)c3)nc3ccccc3c2=O)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20070082912A1,CCN(CC)CC.Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(S(N)(=O)=O)c1.O=C(Cl)c1ccccc1>>CCc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(S(=O)(=O)NC(=O)c2ccccc2)c1,CN(C)c1ccncc1,ClCCl,,,,val
US20130210844A1,O=[N+]([O-])c1cccc2c(Oc3cc(C(F)(F)F)ccc3F)ccnc12>>Nc1cccc2c(Oc3cc(C(F)(F)F)ccc3F)ccnc12,[Fe],CCO,O,[Cl-].[NH4+],,val
US06472386B1,COc1cc(-c2ccc(C=O)s2)cc(OC)c1OC>>COc1cc(-c2ccc(CO)s2)cc(OC)c1OC,,CO,,[BH4-].[Na+],,val
US20120258982A1,CC(=O)c1cccnc1Nc1ccccc1.COC(=O)c1ccc(C=O)cc1>>COC(=O)c1ccc(/C=C/C(=O)c2cccnc2Nc2ccccc2)cc1,,CO,O,Cl,C[O-].[Na+],val
US20090042892A1,C[C@@H]1NC(=O)O[C@@H]1c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Clc1ccc(Br)c(CBr)n1>>C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(Cl)ccc1Br,,C1CCOC1,,[H-].[Na+],,val
US20140155367A1,N#Cc1ccc(Br)nc1.NC1COC1>>N#Cc1ccc(NC2COC2)nc1,,CC(C)O,,CCN(CC)CC,,val
US05344830,CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)C(C(=O)N(C)CCN(CC(N)=O)C(=O)OCc2ccccc2)C1>>CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCNCC(N)=O)C1,[Pd],CCO,,,,val
US20110021521A1,COCC(F)(F)C(=O)OC.NNc1ccc(Br)cn1>>COCC(F)(F)C(=O)NNc1ccc(Br)cn1,,Cc1ccccc1,,,,val
US06423716B1,COc1cc2ncnc(N3CCN(C(=C[N+](=O)[O-])SC)CC3)c2cc1OC.NCc1ccncc1>>COc1cc2ncnc(N3CCN(C(=C[N+](=O)[O-])NCc4ccncc4)CC3)c2cc1OC,,c1ccncc1,,,,val
US06100260,CC(c1ccc(-c2ccccc2)c(F)c1)c1cc(CN=C(NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)no1>>CC(c1ccc(-c2ccccc2)c(F)c1)c1cc(CNC(=N)N)no1,,O=C(O)C(F)(F)F,,,,val
US20100056576A1,C[C@@H](CN=[N+]=[N-])[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1COC(C)(C)O1>>C[C@@H](CN=[N+]=[N-])[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)CO,,CO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20040102634A1,CCOC(=O)COC(C)C.O=Cc1cccc(OCc2ccccc2)c1>>CCOC(=O)C(OC(C)C)C(O)c1cccc(OCc2ccccc2)c1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20140121200A1,CC(C)(C)OC(=O)N1CCCC(F)(CN)C1.Clc1cc2nccnc2c(Cl)n1>>CC(C)(C)OC(=O)N1CCCC(F)(CNc2nc(Cl)cc3nccnc23)C1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20120101127A1,CC1(C)CC(c2ccccc2N)Nc2ccc(Cl)cc21.CCS(=O)(=O)Cl>>CCS(=O)(=O)Nc1ccccc1C1CC(C)(C)c2cc(Cl)ccc2N1,,ClCCl,,c1ccncc1,,val
US20140018393A1,COC(=O)c1ccc(CN2CCC(C=O)CC2)cc1.N[C@@H]1C[C@H]1c1ccc(I)cc1>>COC(=O)c1ccc(CN2CCC(CN[C@@H]3C[C@H]3c3ccc(I)cc3)CC2)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20070142372A1,Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2[nH]ncc2c1.ClCC1CN(Cc2ccccc2)CCO1>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(cnn2CC2CN(Cc3ccccc3)CCO2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20100216788A1,CC(C)(C)OC(=O)NCCn1ccc2ncnc(Cl)c21.Cc1cc(N)ccc1Oc1cccc(OCCC(C)C)c1>>Cc1cc(Nc2ncnc3ccn(CCNC(=O)OC(C)(C)C)c23)ccc1Oc1cccc(OCCC(C)C)c1,,CC(C)O,,,,val
US20090318412A1,CC(C)(C)OC(=O)N1CCN2C(=O)c3c(Br)cccc3OCC2C1.OB(O)C1CC1>>CC(C)(C)OC(=O)N1CCN2C(=O)c3c(cccc3C3CC3)OCC2C1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20060122065A1,BrCc1ccccc1.COc1cc(CCC(=O)NCc2ccc(Cl)cc2)ccc1O>>COc1cc(CCC(=O)NCc2ccc(Cl)cc2)ccc1OCc1ccccc1,,CCOC(C)=O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US04983755,CNN=C(c1ccc(Cl)cc1)C(C)(C)C.COC(=O)Cl>>COC(=O)N(C)N=C(c1ccc(Cl)cc1)C(C)(C)C,,ClCCl,,CCN(CC)CC,O,val
US20100331326A1,Cc1ccncc1N1CCNC1=O.N#Cc1cccc(Br)c1>>Cc1ccncc1N1CCN(c2cccc(C#N)c2)C1=O,I[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20070249670A1,CC(C)(C)OC(=O)[C@@H](NC(=O)c1ccc(Cl)cc1N)C1CCCCC1.Cc1cc(C)c(N=C=O)c(C)c1>>Cc1cc(C)c(NC(=O)Nc2cc(Cl)ccc2C(=O)N[C@H](C(=O)OC(C)(C)C)C2CCCCC2)c(C)c1,,c1ccncc1,,CCCCCC,CCOC(C)=O,val
US04315016,CC(=O)Cl.O=Cc1ccc(Cl)cc1.c1nc[nH]n1>>CCOC(c1ccc(Cl)cc1)n1cncn1,[Cu],,,,,val
US20020143017A1,COc1ccc(S(=O)(=O)F)nn1.c1cc[nH]c1>>COc1ccc(S(=O)(=O)n2cccc2)nn1,,CN(C)C=O,,[H-].[Na+],,val
US04599361,CCOC(=O)C(C)=C(CC(C)C)C(=O)OCc1ccccc1>>CCOC(=O)C(C)C(CC(C)C)C(=O)O,[Pd],CO,,,,val
US03984413,CC(C)(Oc1ccc(Cl)cc1)C(=O)O.Cn1c(=O)c2c(ncn2CCO)n(C)c1=O>>Cn1c(=O)c2c(ncn2CCOC(=O)C(C)(C)Oc2ccc(Cl)cc2)n(C)c1=O,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1C,,O,O=C([O-])O.[Na+],val
US20150274696A1,CCOC(=O)c1cnn2ccc(NC(=O)OC(C)(C)C)cc12>>Nc1ccn2nccc2c1,,O=S(=O)(O)O,,,,val
US04889553,CC(=O)n1nc(S(=O)(=O)Cl)nc1N.Nc1c(Cl)cccc1Cl.c1ccncc1>>CC(=O)n1nc(S(=O)(=O)Nc2c(Cl)cccc2Cl)nc1N.c1cc[nH+]cc1,,c1ccncc1,,,,val
US04536402,N/C(=C1/Sc2ccccc2C1=O)c1ccccc1.O=C1CCC(=O)N1Br>>N/C(=C1\C(=O)c2ccccc2S1=O)c1ccccc1,,CO,O,,,val
US20070265225A1,COC(=O)CBr.O=C1CCCC(c2ccccc2)N1>>O=C(O)CN1C(=O)CCCC1c1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20140155391A1,COc1ccc(C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)cc1NC(=O)CN1C[C@@H](C)N(C(=O)OC(C)(C)C)C[C@@H]1C>>COc1ccc(C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)cc1NC(=O)CN1C[C@@H](C)NC[C@@H]1C,,C1COCCO1,Cl,,,val
US20060135556A1,Cc1ccc(-n2c(C)nnc2S)c2c1CCCC2.O=C(CCl)Nc1cccnc1Cl>>Cc1ccc(-n2c(C)nnc2SCC(=O)Nc2cccnc2Cl)c2c1CCCC2,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060229337A1,CCOC(=N)c1ccc(Nc2nc(-c3cccc(NC(=O)c4ccc(C(C)(C)C)cc4)c3C)cn3ccnc23)cc1.NCCN>>Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn2ccnc2c(Nc2ccc(C3=NCCN3)cc2)n1,,CO,,Cl,,val
US20020094989A1,CC(C)(C)OC(=O)N1CCC(CO)CC1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCC(OS(C)(=O)=O)CC1,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20130079377A1,CS(=O)(=O)Cl.Cc1cccc(-c2nc(C(F)(F)F)ccc2CNC(=O)C(C)c2cccc(CN)c2)c1>>Cc1cccc(-c2nc(C(F)(F)F)ccc2CNC(=O)C(C)c2cccc(CNS(C)(=O)=O)c2)c1,,ClCCl,,CCN(CC)CC,,val
US20050277674A1,CN(C)C1(c2ccccc2)CCC(N2CC=C(c3c[nH]c4ccccc34)CC2)CC1.C[Si](C)(C)Cl.Cl>>CN(C)C1(c2ccccc2)CCC(N2CC=C(c3c[nH]c4ccccc34)CC2)CC1.Cl.Cl,,CCC(C)=O,,,,val
US20060281794A1,Nc1cc(Cl)ccc1C(=O)O.O=C=Nc1ccccc1F>>O=C(Nc1ccccc1F)Nc1cc(Cl)ccc1C(=O)O,,Cc1ccccc1,,CCN(CC)CC,,val
US20120172376A1,FCCBr.O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2ccc(C3CCNCC3)cc12>>O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2ccc(C3CCN(CCF)CC3)cc12,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],O=C([O-])O.[Na+],val
US20160244410A1,CCS(=O)(=O)Nc1cccc(Oc2cc(=O)n(C)c(Nc3ccc(I)cc3F)c2C(N)=O)c1C.O=C1CCC(=O)N1Cl>>CCS(=O)(=O)Nc1cccc(Oc2c(C(N)=O)c(Nc3ccc(I)cc3F)n(C)c(=O)c2Cl)c1C,,ClCCl,,,,val
US20080207666A1,CC1(C)CC(NC(=O)NC(=O)CCl)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1>>CC1(C)CC(N2CC(=O)NC2=O)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1,,CCOC(C)=O,CS(C)=O,[H-].[Na+],,val
US04654363,CCC1(C(C)C(=O)[O-])C=CC(Cl)=CC1C.O=C1CCC(=O)O1>>CCOC(=O)CCc1cc(C(=O)CCC(=O)O)c(Cl)cc1C,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20050004083A1,CCO[PH](=O)CCCCC1=CC(O[Si](C)(C)C(C)(C)C)CC1>>CCO[PH](=O)CCCC[C@H]1CC[C@@H](O[Si](C)(C)C(C)(C)C)C1,[Pd],CCO,,,,val
US20100168062A1,COCCCl.Fc1cc(-c2cccc3ncc(-c4cnn(C5CCNCC5)c4)nc23)cc(F)c1CN1CCOCC1>>CC(=O)N1CCC(n2cc(-c3cnc4cccc(-c5cc(F)c(CN6CCOCC6)c(F)c5)c4n3)cn2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060172319A1,NCc1ccc(N)cc1.O=C(CI)ON1C(=O)CCC1=O>>Nc1ccc(CNC(=O)CI)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04803215,NN.O=S(=O)(c1cnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1Br)C(F)(F)F>>NNc1c(S(=O)(=O)C(F)(F)F)cnn1-c1c(Cl)cc(C(F)(F)F)cc1Cl,,C1COCCO1,,O,,val
US20140275071A1,Cc1cccc(CO)c1.Cn1c(=O)n(CCOCCOC2CCCCO2)c(=O)c2c1nc(Br)n2Cc1ccc(Cl)cc1>>Cc1cccc(COc2nc3c(c(=O)n(CCOCCOC4CCCCO4)c(=O)n3C)n2Cc2ccc(Cl)cc2)c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20120157433A1,CC(C)(C)OC(=O)Nc1cccc(-c2cc(F)ncc2Cl)c1.Cc1ccc(S(=O)(=O)OCC2CCOCC2)cc1>>CC(C)(C)OC(=O)N(CC1CCOCC1)c1cccc(-c2cc(F)ncc2Cl)c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20140155413A1,BrCCCc1ccccc1.COC(=O)c1cc2c(-c3cccc(OC)c3)nccc2[nH]1>>COC(=O)c1cc2c(-c3cccc(OC)c3)nccc2n1CCCc1ccccc1,,CCOC(C)=O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US04612376,CC(C)Br.COc1ccc(-c2cc(=O)n(C)c(=O)[nH]2)cc1OC>>COc1ccc(-c2cc(=O)n(C)c(OC(C)C)n2)cc1OC,,CN(C)C=O,,O,[H-].[Na+],val
US05891889,CCOC(=O)C1(Cc2cc(C)ccn2)CCN(C(=O)OC(C)(C)C)CC1>>Cc1ccnc(CC2(CO)CCN(C(=O)OC(C)(C)C)CC2)c1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120122900A1,CC(=O)Cc1ccc(Cl)cc1.COC(=O)[C@H](CI)NC(=O)OC(C)(C)C>>COC(=O)C(CC(C(C)=O)c1ccc(Cl)cc1)NC(=O)OC(C)(C)C,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150353533A1,CCOC(=O)c1cc(C(=O)c2ccccc2)on1>>O=C(O)c1cc(C(O)c2ccccc2)on1,,CO,,[BH4-].[Na+],,val
US04689346,CC(=O)OC(C)=O.Nc1ccc(S(=O)(=O)O)c2ccccc12.c1ccncc1>>CC(=O)Nc1ccc(S(=O)(=O)O)c2ccccc12.c1ccncc1,,CCO,,,,val
US20020026060A1,CCCCCC(C(=O)O)c1ccc2c(c1)C(C)(C)CC(C)(C)O2>>CCCCCC(CO)c1ccc2c(c1)C(C)(C)CC(C)(C)O2,,C1CCOC1,,B,,val
US05138069,CCCCc1nc(Cl)c(C=O)[nH]1.O=[N+]([O-])c1ccc(F)cc1>>CCCCc1nc(Cl)c(C=O)n1-c1ccc([N+](=O)[O-])cc1,,CO,,C[O-].[Na+],,val
US05047545,COC(=O)CCC(C#N)(CCC(=O)O)c1ccncc1>>COC(=O)CCC(CCC(=O)O)c1ccncc1,,Cl,,,,val
US04683234,CCC(=O)Cl.CCOC(=O)C1=C(C)NC(C)N=C1c1ccccc1[N+](=O)[O-]>>CCOC(=O)C1=C(C)N=C(C)N(C(=O)CC)C1c1ccccc1[N+](=O)[O-],,ClC(Cl)Cl,,CCN(CC)CC,,val
US20120053146A1,CCOC(=O)C1(CO)CC1.CCOC(=O)C1(COS(C)(=O)=O)CC1>>CSCC1(C(=O)O)CC1,,ClCCl,O,CCN(CC)CC,CS(=O)(=O)Cl,val
US20110152240A1,O=C(Cl)C1CC1.O=C1NC(=O)C(=Cc2cnn3c(NC4CCNCC4)cc(Nc4cccc(Cl)c4)nc23)N1>>O=C1NC(=O)C(=Cc2cnn3c(NC4CCN(C(=O)C5CC5)CC4)cc(Nc4cccc(Cl)c4)nc23)N1,,C1CCOC1,,,,val
US20100075948A1,C=CC(C)(C)CC1NC(C(=O)NCC[C@H]2COC(C)(C)O2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F>>CCC(C)(C)CC1NC(C(=O)NCC[C@H]2COC(C)(C)O2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F,O=[Pt]=O,CCOC(C)=O,,,,val
US20040002526A1,COC(=O)c1ccc(-c2ccc(C=O)o2)cc1.O=C1CSC(=S)N1CCCN1CCOCC1>>COC(=O)c1ccc(-c2ccc(C=C3SC(=S)N(CCCN4CCOCC4)C3=O)o2)cc1,C1CCNCC1,CCO,,,,val
US20160207905A1,Cc1ccc(S(=O)(=O)OC2CCOC2)cc1.O=[N+]([O-])c1cn[nH]c1>>O=[N+]([O-])c1cnn(C2CCOC2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020004518A1,CCOC(=O)c1ccc(C(=O)c2ccccc2)cc1.NNCc1ccccc1>>CCOC(=O)c1ccc(-c2nn(Cc3ccccc3)c3ccccc23)cc1,,CC(=O)O,,,,val
US20070021454A1,C#CC(C)(C)Cl.COC(=O)c1ccccc1N>>C#CC(C)(C)Nc1ccccc1C(=O)OC,[Cu],C1CCOC1,O,CCN(CC)CC,,val
US20060063811A1,CCOC(=O)c1cc(C)nc(Cl)c1>>Cc1cc(CO)cc(Cl)n1,,CC(C)(C)O,,CO,[BH4-].[Na+],val
US20040142931A1,CCc1c(C(=O)OC)cn2nc[nH]c(=O)c12.O=P(Cl)(Cl)Cl>>CCc1c(C(=O)OC)cn2ncnc(Cl)c12,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US20080058358A1,CC(C)N.Clc1ncc(Br)c(Cl)n1>>CC(C)Nc1nc(Cl)ncc1Br,,CC#N,,CCN(CC)CC,,val
US20080058321A1,COc1ccc(CCCC(=O)C(=O)O)cc1>>COc1ccc(CCCC(O)C(=O)O)cc1,,O,,Cl,[Na+].[OH-],val
US20040082780A1,CC(=O)OC(C)=O.Nc1cc(C(F)(F)F)ccc1-c1cc(Oc2ccc3cccnc3c2)ncn1>>CC(=O)Nc1cc(C(F)(F)F)ccc1-c1cc(Oc2ccc3cccnc3c2)ncn1,,ClCCCl,,O,O=C([O-])O.[Na+],val
US20110301161A1,Cc1nnc(Br)s1.O=Cc1ccccc1B(O)O>>Cc1nnc(-c2ccccc2C=O)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],val
US20070185133A1,NC(=S)Nc1ccc(F)cc1.O=CCCl>>Fc1ccc(Nc2nccs2)cc1,,CCO,,CCOC(C)=O,,val
US20090318456A1,CCOC(=O)c1ccc(C(=O)C=NO)cc1.CSc1nc(N)c(N)c(O)n1>>CCOC(=O)c1ccc(-c2cnc3nc(SC)nc(O)c3n2)cc1,,CO,,Cl,Cl,val
US20150284395A1,CCOC(=O)CC(=O)c1ccc2[nH]nnc2c1.CCOC(O)C1CNNC1N>>CCOC(=O)c1cnn2c(=O)cc(-c3ccc4[nH]nnc4c3)[nH]c12,Cc1ccc(S(=O)(=O)O)cc1,CCCCO,,,,val
US20080139548A1,CCOC(=O)c1cc2cc(Cl)cc(CC#N)c2n1C(=O)OC(C)(C)C>>CCOC(=O)c1cc2cc(Cl)cc(CC#N)c2[nH]1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04704399,COC(=O)CCCCCCC=O.Cc1ccccc1CC(=O)O>>COC(=O)CCCCCCC(O)C(C(=O)O)c1ccccc1C,,C1CCOC1,CCCCCC,CC(=O)O,[Li]CCCC,val
US20090181948A1,C1CCNC1.N#CC(C#N)=C1N(CCBr)CCN1CCCO>>N#CC(C#N)=C1N(CCCO)CCN1CCN1CCCC1,,C1COCCO1,,O,,val
US20120157469A1,OCc1cc2ccc(Br)cc2[nH]1>>O=Cc1cc2ccc(Br)cc2[nH]1,O=[Mn]=O,C1CCOC1,,,,val
US04501697,COC(=O)COC[C@@H]1[C@H](N=[N+]=[N-])C(=O)N1c1ccc(OC)cc1>>COC(=O)COC[C@H]1NC(=O)[C@H]1N=[N+]=[N-],,CC#N,O,,,val
US20010000177A1,NC(=S)c1ccc(F)cc1.O=C(CBr)c1ccc(Br)cc1>>Fc1ccc(-c2nc(-c3ccc(Br)cc3)cs2)cc1,,CCO,,,,val
US20130131039A1,CC(C)(C)OC(=O)N1CCC(=O)C1.CCOP(=O)(CC#N)OCC>>CC(C)(C)OC(=O)N1CCC(=CC#N)C1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US05281748,BrCCCOc1ccccc1.CCOP(=O)(OCC)C(N)P(=O)(OCC)OCC>>CCOP(=O)(OCC)C(NCCCOc1ccccc1)P(=O)(OCC)OCC,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20120202785A1,CC(N=[N+]=[N-])c1oc2ccccc2c1-c1ccccc1>>CC(N)c1oc2ccccc2c1-c1ccccc1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05856334,Cl.OC1CCn2c(CCc3ccccc3)nc3cccc1c32>>Cl.OC1CCn2c(CCc3ccccc3)nc3cccc1c32,,CCOCC,ClCCl,CO,,val
US20100130474A1,O=C(O)CCCN1CCCC1.O=C(n1ccnc1)n1ccnc1.[NH3+]c1[nH]nc(-c2ccc3ncccc3c2)c1F>>O=C(CCCN1CCCC1)Nc1[nH]nc(-c2ccc3ncccc3c2)c1F.O=CO,,ClCCCl,,Cl,,val
US05922724,CC(=O)Nc1ccc(-c2ccoc2)cc1[N+](=O)[O-].O=C(O)c1cccc(I)c1>>O=C(O)c1cccc(Nc2ccc(-c3ccoc3)cc2[N+](=O)[O-])c1,,CN1CCCC1=O,,O,O=C([O-])[O-].[K+].[K+],val
US04859692,CCC(C(=O)O)c1ccccc1.COC(=O)c1ccc(Cn2cnc3ccc(N)cc32)c(OC)c1>>CCC(C(=O)Nc1ccc2ncn(Cc3ccc(C(=O)OC)cc3OC)c2c1)c1ccccc1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20050214287A1,CN1CCCC1CCN.O=Cc1cc2ccccc2o1>>CN1CCCC1CCNCc1cc2ccccc2o1,,ClCCl,,[Na],,val
US20130072467A1,C#CCNC1=NC(=O)S/C1=C\C1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)C1.O=C(O)/C=C\C(=O)O>>C#CCNC1=NC(=O)S/C1=C\C1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)C1.O=C(O)/C=C\C(=O)O,,CCO,,,,val
US20150274664A1,BrCc1ccc(Br)cn1.CC(C)(C)OC(=O)N1CCC([C@H]2C[C@@H]2CO)CC1>>CC(C)(C)OC(=O)N1CCC([C@H]2C[C@@H]2COCc2ccc(Br)cn2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US04005099,CN(C)Cc1ncc(CN2C(=O)c3ccccc3C2=O)n1-c1ccc(Br)cc1C(=O)c1ccccn1>>CN(C)Cc1ncc2n1-c1ccc(Br)cc1C(c1ccccn1)=NC2,,CCO,,NN,O,val
US04315861,CC(C)=O.CCN(CC)CC.COC(=O)Nc1cccc(O)c1>>COC(=O)Nc1cccc(-c2ccccc2OC(N)=O)c1,,CC(C)=O,,O,,val
US20030171394A1,COC(=O)Cl.Cn1[nH]c(=O)c2c1NC1=C(C(=O)CC1)C2c1ccc(F)c(Br)c1>>COC(=O)n1c(=O)c2c(n1C)NC1=C(C(=O)CC1)C2c1ccc(F)c(Br)c1,,ClCCl,,c1ccncc1,,val
US05807863,CNC.COC(=O)Cc1c(Cl)nc(C)nc1Cl.O=c1ccn(-c2ccccc2)[nH]1>>COC(=O)Cc1c(Oc2ccn(-c3ccccc3)n2)nc(C)nc1N(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070185089A1,Nc1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.c1cc2c(cc1N1CCNCC1)CCN(C1CCC1)CC2>>O=C(Nc1ccccc1)N1CCN(c2ccc3c(c2)CCN(C2CCC2)CC3)CC1,,C1CCOC1,CC(=O)O,CCN(C(C)C)C(C)C,,val
US20030199440A1,CC(C)(NS(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1)C(N)=O.Cl.N=C(N)N>>CC(C)(NS(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1)C(N)=O.Cl,,CS(C)=O,,[H-].[Na+],,val
US20080119518A1,CNC(=O)c1ccc2ccn(C3CCNCC3)c2c1.COc1ccc(C(=O)N(C)C)cc1CC=O>>CNC(=O)c1ccc2ccn(C3CCN(CCc4cc(C(=O)N(C)C)ccc4OC)CC3)c2c1,,CC(=O)O,ClCCl,O=C([O-])O.[Na+],,val
US20160198713A1,O=C(Cl)C(=O)Cl.O=C(O)CC(=O)OCc1ccccc1>>O=C(Cl)CC(=O)OCc1ccccc1,,ClCCl,,CN(C)C=O,,val
US20040014108A1,C[C@@]1(O)[C@H](OCc2ccc(Cl)cc2Cl)[C@@H](COCc2ccc(Cl)cc2Cl)O[C@H]1n1ccc2c(Cl)ncnc21>>C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1ccc2c(Cl)ncnc21,,ClCCl,,ClB(Cl)Cl,,val
US20050171110A1,O=c1c(Cl)c(Cl)c(OCc2ccccc2)nn1Cc1ccccc1.OB(O)c1ccc(Cl)cc1>>O=c1c(-c2ccc(Cl)cc2)c(Cl)c(OCc2ccccc2)nn1Cc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20100240623A1,CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(Cc3cccc(CC(=O)OC)c3)C(=O)CN)c2n1.CS(=O)(=O)OS(C)(=O)=O>>CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(Cc3cccc(CC(=O)OC)c3)C(=O)CNS(C)(=O)=O)c2n1,,CN1CCCC1=O,,c1ccncc1,,val
US04303655,CCC(C)(C)OC(=O)Cl.CCOC(=O)Cc1csc(=N)[nH]1>>CCOC(=O)Cc1csc(NC(=O)OC(C)(C)CC)n1,,ClCCl,c1ccncc1,CCOCC,O,val
US20090012129A1,CCCCCN.CCOC(=O)/C(=C/c1ccc(-c2cccc(N(C)C(=O)Oc3ccc([N+](=O)[O-])cc3)n2)cc1)OCC>>CCCCCNC(=O)N(C)c1cccc(-c2ccc(/C=C(\OCC)C(=O)OCC)cc2)n1,,CN(C)C=O,,CCOC(C)=O,O,val
US20050143385A1,Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1.O=C(O)C=Cc1ccc(S(=O)(=O)Cl)cc1>>O=C(O)/C=C/c1ccc(S(=O)(=O)N2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1,,C1COCCO1,O,Cl,O=C([O-])O.[Na+],val
US20060025433A1,COC(=O)CCCNC1CCC(CNc2nc(NCc3ccccc3OC(F)(F)F)ncc2[N+](=O)[O-])CC1>>O=C(O)CCCN[C@@H]1CC[C@@H](CNc2nc(NCc3ccccc3OC(F)(F)F)ncc2[N+](=O)[O-])CC1,,CO,,O,[Li+].[OH-],val
US05461067,CN1CCOCC1.COC(=O)[C@](N)(N=C=O)C(C)C.c1ccncc1>>COC(=O)[C@@H](NC(=O)N(C)Cc1ccccn1)C(C)C,,ClCCl,,Cl,Cl,val
US06627651B1,COC(=O)C1=Cc2cc(OCc3ccc(F)cc3)ccc2S(=O)(=O)CC1>>O=C(O)C1=Cc2cc(OCc3ccc(F)cc3)ccc2S(=O)(=O)CC1,,C1CCOC1,CO,Cl,O=C([O-])[O-].[K+].[K+],val
US20100099673A1,O=C(OCc1ccccc1)N1CCC(O)(c2ccccc2)[C@@H]2CCCC[C@@H]21>>OC1(c2ccccc2)CCN[C@H]2CCCC[C@H]21,[Pd],CCO,,,,val
US20070208013A1,Nc1ncnn2cc(CO)c(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12>>Nc1ncnn2cc(C=O)c(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12,,C1CCOC1,CCOC(C)=O,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090018160A1,C#CCCCCCCC.CCCCC#Cc1c[nH]nc1C1=CCCN(C)C1.CCOCC.O=S(=O)(c1ccccc1)n1cc(I)c(-c2cccnc2)n1>>CCCCCCCC#Cc1c[nH]nc1-c1cccnc1.CCCCCCCC#Cc1cn(S(=O)(=O)c2ccccc2)nc1-c1cccnc1,,CCOCC,,,,val
US20050075373A1,CCOC(C)=NC(=O)c1cccc(Cl)c1.NNc1ccc(S(N)(=O)=O)cn1>>Cc1nc(-c2cccc(Cl)c2)n(-c2ccc(S(N)(=O)=O)cn2)n1,,CO,ClCCl,O,,val
US20040072839A1,CC(=O)Cl.COc1ccccc1N1CCN(CCC(c2ccccc2F)C(O)C2CCCCC2)CC1>>COc1ccccc1N1CCN(CCC(c2ccccc2F)C(OC(C)=O)C2CCCCC2)CC1,,ClCCl,,,,val
US20100120798A1,CC(C)(C)OC(=O)N1CCC(CN=C(c2ccccc2)c2ccccc2)(C(=O)Nc2cc(C(F)(F)F)ccn2)CC1>>O=C(Nc1cc(C(F)(F)F)ccn1)C1(CN=C(c2ccccc2)c2ccccc2)CCNCC1,,C1COCCO1,CO,Cl,,val
US20070135477A1,O=C(Nc1c[nH]nc1-c1nc2c(CO)cccc2[nH]1)c1c(F)cccc1F>>O=Cc1cccc2[nH]c(-c3n[nH]cc3NC(=O)c3c(F)cccc3F)nc12,O=[Mn]=O,CO,ClCCl,,,val
US20120172345A1,C1COCCN1.NS(=O)(=O)c1sc(Br)nc1Br>>NS(=O)(=O)c1sc(N2CCOCC2)nc1Br,,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100048568A1,CS(=O)(=O)c1ccc2cc[nH]c2c1.NCl>>CS(=O)(=O)c1ccc2ccn(N)c2c1,,CCOCC,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US20060160829A1,COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(CC(=O)C(C)(C)C)c(=O)n2Cc1c(F)cccc1F>>COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(CC(O)C(C)(C)C)c(=O)n2Cc1c(F)cccc1F,,C1CCOC1,CO,[BH4-].[Na+],,val
US04563472,CCOC(=O)c1c[nH]c(Cl)c1Cl.Cc1ccc(S(=O)(=O)OCC(I)=C(I)I)cc1>>CCOC(=O)c1cn(CC(I)=C(I)I)c(Cl)c1Cl,,CN(C)C=O,,CCN(CC)CC,O,val
US20110112065A1,CCCN.Fc1cc2c(cc1Br)OC(CBr)OC2>>CCCNCC1OCc2cc(F)c(Br)cc2O1,,CCO,,,,val
US06028096,C#C[Si](C)(C)C.N#Cc1nn(-c2c(Cl)cc(OC(F)(F)F)cc2Cl)c(N)c1I>>C[Si](C)(C)C#Cc1c(C#N)nn(-c2c(Cl)cc(OC(F)(F)F)cc2Cl)c1N,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,O,CCN(CC)CC,,val
US20130190487A1,O=C(Cl)CC[C@H]1C(=O)N(c2ccc(F)cc2)[C@@H]1c1ccc(OCc2ccc(Br)cc2)cc1.c1ccc2[nH]nnc2c1>>O=C1[C@H](CCC(=O)n2nnc3ccccc32)[C@@H](c2ccc(OCc3ccccc3)cc2)N1c1ccc(F)cc1,,ClCCl,,,,val
US20050131012A1,Fc1cccc(SSc2cccc(F)c2)c1.NC(=O)c1cc2ncccc2[nH]1>>NC(=O)c1[nH]c2cccnc2c1Sc1cccc(F)c1,,CN(C)C=O,,,,val
US20140329799A1,COc1nc(S(C)(=O)=O)nc(N[C@@H]2C[C@H](CO)[C@H]3OC(C)(C)O[C@@H]23)c1-c1nc2ccccc2s1.NC1CCC1>>CC1(C)O[C@H]2[C@H](Nc3nc(NC4CCC4)[nH]c(=O)c3-c3nc4ccccc4s3)C[C@H](CO)[C@H]2O1,,CC#N,,,,val
US20110124696A1,CC(C)(C)c1cc(N)no1.CC1(S(=O)(=O)c2ccc(Cl)cc2)CCOC1=O>>CC(C)(C)c1cc(NC(=O)C(C)(CCO)S(=O)(=O)c2ccc(Cl)cc2)no1,,Cc1ccccc1,ClCCl,C[Al](C)C,,val
US20100105642A1,Cn1cc(-c2cccc(CCOCCC(=O)N(CCN(CCc3ccc(OC(=O)OC(C)(C)C)c4c3OCC(=O)N4)C(=O)OC(C)(C)C)C3CCCCCC3)c2)nn1.O=C(O)C(F)(F)F>>Cn1cc(-c2cccc(CCOCCC(=O)N(CCNCCc3ccc(O)c4c3OCC(=O)N4)C3CCCCCC3)c2)nn1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20060252812A1,CCOC(=O)CN1C(=O)C(O)(c2cc(F)c(F)cc2O)c2c(Br)cccc21>>CCOC(=O)CN1C(=O)C(c2cc(F)c(F)cc2O)c2c(Br)cccc21,,CCOC(C)=O,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20160083321A1,CC(C)(C=O)CO.CCC(CO)(CO)CO>>CCC1(CO)COC(C(C)(C)CO)OC1,,c1ccccc1,,O,,val
US20080188566A1,C=CC[C@@H](Cc1cc(C)c(F)c(C)c1)C(=O)N1C(=O)OC[C@H]1Cc1ccccc1.CNCCCc1ccc(F)cc1>>Cc1cc(C[C@@H](CCN(C)CCCc2ccc(F)cc2)C(=O)N2C(=O)OC[C@H]2Cc2ccccc2)cc(C)c1F,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100041748A1,COC(=O)c1cc(NC(=O)CNC(=O)OC(C)(C)C)ccc1O>>COC(=O)c1cc(NC(=O)CN)ccc1O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080269196A1,ClCc1ccc(Cl)nc1.SC1CCCC1>>Clc1ccc(CSC2CCCC2)cn1,,CO,,[K+].[OH-],,val
US20090306066A1,CNCc1csc(N)n1.Cc1nc(Cl)c(F)c(Cl)n1>>Cc1nc(Cl)c(F)c(NCc2csc(N)n2)n1,,C1CCOC1,,CCN(CC)CC,,val
US07825160B2,CCCI.O=C(O)Cc1cc(OCc2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)c1>>CCCC(C(=O)O)c1cc(OCc2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120245163A1,CC(=O)CCl.CC(C)(C)OC(=O)N[C@H]1CC[C@@H](C(N)=O)C1>>Cc1coc([C@@H]2CC[C@H](N)C2)n1.Cl,,CCO,,,,val
US04061761,CN(C)S(=O)(=O)c1cc(C2(O)SN=C3NCN=C32)ccc1Cl>>CN(C)S(=O)(=O)c1cc(C2(O)SN=C3NCN=C32)ccc1Cl,,O,,Br,O=C([O-])O.[Na+],val
US20070072873A1,COC(=O)c1cscc1N.O=C(O)COc1ccc(Br)cn1>>COC(=O)c1cscc1NC(=O)COc1ccc(Br)cn1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040171641A1,NO.O=S(=O)(/C=C/c1ccccc1)N1CCN(c2ccc(F)cc2)CC1>>O=S(=O)(CC(NO)c1ccccc1)N1CCN(c2ccc(F)cc2)CC1,,C1CCOC1,,,,val
US20030114666A1,BrCC1CC1.COn1c(=O)[nH]c2cc(F)c(F)cc2c1=O>>COC1CC1(C)n1c(=O)[nH]c(=O)c2cc(F)c(F)cc21,,ClC(Cl)Cl,,CN(C)C=O,[H-].[Na+],val
US04649146,COc1ccc(CCN)cc1OC.Cc1nc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)sc1C(=O)O>>COc1ccc(CCNC(=O)c2sc(NC(c3ccccc3)(c3ccccc3)c3ccccc3)nc2C)cc1OC,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20090181928A1,CN(C)C=O.c1ccc(COCn2cccn2)cc1>>O=Cc1ccnn1COCc1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20080269271A1,C=C1CCN(Cc2ccccc2)C1.ON=CC1(Cl)C=CC=CC1>>c1ccc(CN2CCC3(CC(c4ccccc4)=NO3)C2)cc1,,O,,CCN(CC)CC,ClCCl,val
US20040209865A1,ClCCN1CCCC1.Oc1ccc(Br)cc1Cl>>Clc1cc(Br)ccc1OCCN1CCCC1,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20050256099A1,COC(=O)[C@@H](Cc1cc(C)c2[nH]cnc2c1)OC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc2nc[nH]c12,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20150353559A1,O=Cc1ccc(O)cc1F.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>O=Cc1ccc(OCC(F)(F)F)cc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160002217A1,CC(C)(C)OC(=O)Nc1cccc(CON=C(C#N)c2cccnc2)n1.NO>>CC(C)(C)OC(=O)Nc1cccc(CON=C(C(N)=NO)c2cccnc2)n1,,CC(C)O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20120178752A1,COC(=O)c1cccc([C@H]2CCCN2C(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)N1CCC[C@@H]1c1cccc(C(=O)O)c1,,CO,O,[Na+].[OH-],,val
US20120035364A1,OC1C2=C(C3C=CC2CC3)C(O)c2cc3sc(=S)sc3cc21>>S=c1sc2cc3cc4c(cc3cc2s1)C1C=CC4CC1,,c1ccncc1,,O,,val
US20110207926A1,CC(C)=O.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.CCCCCCCCCNC(=N)NC(=NCc1ccccc1)NC.CCO>>CC(=O)O.CCCCCCCCCNC1=NC(C)(C)NC(N(C)Cc2ccccc2)=N1,,CC(C)=O,,Cl,Cl,val
US20150336935A1,COc1cc(OC)cc(C(=O)[C@H]2[C@H](C)[C@@H](CN=[N+]=[N-])C[C@H]3C(C)(C)CCC[C@]23C)c1>>COc1cc(OC)cc(C(=O)[C@H]2[C@H](C)[C@@H](CN)C[C@H]3C(C)(C)CCC[C@]23C)c1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140235628A1,O=C(O)Cc1ccc(-n2cnnn2)cc1.OCC1C2CNCC12>>O=C(Cc1ccc(-n2cnnn2)cc1)N1CC2C(CO)C2C1,,ClCCl,O,CCN(CC)CC,ClCCCl,val
US20080009530A1,CCCCCOC(=O)Cl.CCCCOc1cc(CCS(N)(=O)=O)n(Cc2ccc(Cl)cc2Cl)n1>>CCCCCOC(=O)NS(=O)(=O)CCc1cc(OCCCC)nn1Cc1ccc(Cl)cc1Cl,CN(C)c1ccncc1,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20110105463A1,CCOC(=O)C1CCOc2c1cc(Cl)c(Oc1ccc(C(=O)O)cc1)c2Cl.NCCc1ccc(Cl)cc1>>CCOC(=O)C1CCOc2c1cc(Cl)c(Oc1ccc(C(=O)NCCc3ccc(Cl)cc3)cc1)c2Cl,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20150087646A1,CC(C)(C)OC(=O)NNc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1F.O=C=NC(=O)c1ccc(C(F)(F)F)cc1>>CC(C)(C)C(=O)NCc1ccc(Cl)c(-n2nc(-c3ccc(C(F)(F)F)cc3)[nH]c2=O)c1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090054392A1,CC(=O)OC(C)=O.CNCCN(C)[C@@H]1CCN(c2nccc(-c3ccc4ccccc4c3)n2)C1>>CC(=O)N(C)CCN(C)[C@@H]1CCN(c2nccc(-c3ccc4ccccc4c3)n2)C1,,CO,O,CCN(C(C)C)C(C)C,,val
US20090124668A1,CC(C)S(=O)(=O)C[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(C(F)(F)F)c2)C1=O>>CC(C)S(=O)(=O)C[C@@H]1CNCC[C@@H]1N1CC[C@H](NC(=O)c2cccc(C(F)(F)F)c2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20070185111A1,CNC(=O)c1ccccc1C(=O)Cc1ccc(OC)cc1.NN>>COc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1,,CCO,,,,val
US20100222321A1,Cc1nnc2c3cc(-c4ccccc4)c(-c4ccc(C5OCCO5)cc4)nc3ccn12>>Cc1nnc2c3cc(-c4ccccc4)c(-c4ccc(C=O)cc4)nc3ccn12,,C1COCCO1,Cl,,,val
US20090069384A1,CCOC(=O)c1c(I)c2sc(Br)cc2n1CCCc1ccccc1>>O=C(O)c1c(I)c2sc(Br)cc2n1CCCc1ccccc1,,CC#N,,Cl,[Na+].[OH-],val
US20140051679A1,CN1CCC(Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.O=C(NC(c1ccccc1Cl)C1CC1)c1ccc2[nH]nc(I)c2c1>>CN1CCC(Oc2ccc(-c3n[nH]c4ccc(C(=O)NC(c5ccccc5Cl)C5CC5)cc34)cc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20060058367A1,CN(C)C(=O)CC1(O)C(=O)N(Cc2ccccc2)c2ccccc21>>CN(C)C(=O)CC1C(=O)N(Cc2ccccc2)c2ccccc21,[Zn],CC(=O)O,,CC(=O)OC(C)=O,,val
US20150376160A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4sccc4NC(=O)OC(C)c4ccccc4Cl)cc3)cc2)CC1.O=C1CCC(=O)N1Br>>CCOC(=O)C1(c2ccc(-c3ccc(-c4sc(Br)cc4NC(=O)OC(C)c4ccccc4Cl)cc3)cc2)CC1,,CN(C)C=O,,Cc1ccccc1,O=C([O-])O.[Na+],val
US05484462,C1COCCN1.C=CC#N>>NCCCN1CCOCC1,CCN(CC)CC,,,,,val
US20090233919A1,O=C1COCCN1CCOCc1ccccc1>>O=C1COCCN1CCO,[Pd],CCO,,,,val
US20060223814A1,CCOC(=O)CCC(Cc1ccccc1)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NC(CCC(=O)O)Cc1ccccc1,,CO,O,Cl,[Na+].[OH-],val
US20110224219A1,C[C@H]1CC[C@@H](N(C(=O)[C@@H]2CCCO2)[C@H]2C[C@@H](C(=O)N3CCN(C)CC3)N(C(=O)[C@@H]3CN(C(=O)OC(C)(C)C)C[C@H]3c3ccc(Cl)cc3)C2)CC1>>C[C@H]1CC[C@@H](N(C(=O)[C@@H]2CCCO2)[C@H]2C[C@@H](C(=O)N3CCN(C)CC3)N(C(=O)[C@@H]3CNC[C@H]3c3ccc(Cl)cc3)C2)CC1,,ClCCl,,Cl,,val
US20090247573A1,CCCCC1(N(C)C)CCC(c2[nH]c3ccccc3c2C)(c2[nH]c3ccccc3c2CCN)CC1.O=S(=O)(Cl)C1CCCC1>>CCCCC1(N(C)C)CCC(c2[nH]c3ccccc3c2C)(c2[nH]c3ccccc3c2CCNS(=O)(=O)C2CCCC2)CC1,,ClCCl,,CCN(CC)CC,[Na+].[OH-],val
US06653334B1,CCOC(=O)C(C)(C)Br.O=Cc1cccc(O)c1>>CCOC(=O)C(C)(C)Oc1cccc(C=O)c1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20110009454A1,COc1cccc(Oc2ccc(CN)cc2)c1.Nc1nc(F)ccc1C(=O)O>>COc1cccc(Oc2ccc(CNC(=O)c3ccc(F)nc3N)cc2)c1,,CN(C)C=O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20020055519A1,NCc1ccccc1F.O=C(O)C1CCC(Cc2nc3ncccc3[nH]2)CC1>>O=C(NCc1ccccc1F)[C@@H]1CC[C@H](Cc2nc3ncccc3[nH]2)CC1,,CN(C)C=O,,ClCCCl,On1nnc2cccnc21,val
US20070060592A1,CCO.O=C(O)c1cccc2c1CC(=CCCN1CCC(O)(c3ccc(Cl)cc3)CC1)c1cccnc1O2.[N-]=[N+]=NP(=O)(Oc1ccccc1)Oc1ccccc1>>CCOC(=O)Nc1cccc2c1CC(=CCCN1CCC(O)(c3ccc(Cl)cc3)CC1)c1cccnc1O2,,CCOC(C)=O,,CCN(CC)CC,,val
US20100184761A1,CCNCCOc1ccc(-c2cc3c(ncn3C)c(C#N)n2)cc1C(F)(F)F.CN1CCC[C@H]1C(=O)O>>CCN(CCOc1ccc(-c2cc3c(ncn3C)c(C#N)n2)cc1C(F)(F)F)C(=O)[C@@H]1CCCN1C,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040209865A1,CS(=O)(=O)OCCn1ccc2cc(C#Cc3ccc(-c4ccc(Cl)cc4)cn3)ccc21.NCC1CC1>>Clc1ccc(-c2ccc(C#Cc3ccc4c(ccn4CCNCC4CC4)c3)nc2)cc1,,CN(C)C=O,,,,val
US20160251339A1,COc1c(N2CCN(C(=O)C(Cl)(Cl)Cl)CC2)cc(S(=O)(=O)Cl)c2ccccc12.O=Cc1c[nH]c2cc(F)ccc12>>COc1c(N2CCN(C(=O)C(Cl)(Cl)Cl)CC2)cc(S(=O)(=O)n2cc(C=O)c3ccc(F)cc32)c2ccccc12,,C1CCOC1,,[H-].[Na+],,val
US20150152050A1,COC1CCN(C(C(=O)Nc2cc(CC3(C(=O)OC(C)(C)C)CC3)ccc2F)C2CCCC2)CC1.O=C(O)C(F)(F)F>>COC1CCN(C(C(=O)Nc2cc(CC3(C(=O)O)CC3)ccc2F)C2CCCC2)CC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05935990,Cc1ccc(-c2ccc(S(C)(=O)=O)cc2)n1-c1ccc(F)cc1.O=C(Cl)c1ccccc1>>Cc1c(C(=O)c2ccccc2)cc(-c2ccc(S(C)(=O)=O)cc2)n1-c1ccc(F)cc1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20040138211A1,COC(=O)C(Cc1ccc(OCCOc2ccc3c(c2)C(C)(C)CCC3(C)C)cc1)C(=O)O.N>>COC(=O)C(Cc1ccc(OCCOc2ccc3c(c2)C(C)(C)CCC3(C)C)cc1)C(N)=O,,CCOC(C)=O,c1ccccc1,O=S(Cl)Cl,,val
US20030069297A1,Cc1cc(C(=O)NCCn2ccnn2)c(C=O)[nH]1.O=C1Cc2c(cccc2-c2ccc(OC(F)(F)F)cc2)N1>>Cc1cc(C(=O)NCCn2ccnn2)c(C=C2C(=O)Nc3cccc(-c4ccc(OC(F)(F)F)cc4)c32)[nH]1,C1CCNCC1,CCO,,,,val
US20090270454A1,COC(=O)c1ccc(S(=O)(=O)N2CCC(Sc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)CC2)n1C.OCCCBr>>COC(=O)c1ccc(S(=O)(=O)N2CCC(Sc3cc(C(C)(C)C)c(OCCCO)c(C(C)(C)C)c3)CC2)n1C,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20090099213A1,CC(C)(C)OC(=O)N(CC1CCNCC1)c1ccccc1.Clc1ncnc2[nH]ccc12>>CC(C)(C)OC(=O)NC(c1ccccc1)C1CCN(c2ncnc3[nH]ccc23)CC1,,CCCCO,,CCN(CC)CC,,val
US20130035318A1,COC(=O)c1ccc([C@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC[C@@H]3[C@H]5[C@H](C(C)C)CC[C@]5(NCCN5CCS(=O)(=O)CC5)CC[C@]34C)C2(C)C)cc1>>CC(C)[C@@H]1CC[C@]2(NCCN3CCS(=O)(=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](c6ccc(C(=O)O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1COCCO1,,[Na+].[OH-],,val
US20160024009A1,CI.COC(=O)[C@H](CO)NS(=O)(=O)c1ccc(F)cc1>>COC(=O)[C@H](CO)N(C)S(=O)(=O)c1ccc(F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05744466,N#C[O-].c1ccc(CC2CO2)cc1>>O=C1NCC(Cc2ccccc2)O1,,CN(C)C=O,,O,,val
US05157041,CC(C)(C)NC(=O)C1CN(C(=O)OC(C)(C)C)CCN1.O=C(N[C@@H](Cc1ccccc1)[C@H]1CO1)OCc1ccccc1>>NC(=O)N1CCNCC1,,CC(C)O,,,,val
US20160229815A1,COC(=O)c1ccc2nc(-c3ccccc3)c(Br)nc2c1.NC1CCCCC1>>COC(=O)c1ccc2nc(-c3ccccc3)c(NC3CCCCC3)nc2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070185175A1,CCC(C)Nc1nc2ccc(C=O)nc2s1.[C-]#[N+]C(c1ccccc1F)S(=O)(=O)c1ccc(C)cc1>>CCC(C)Nc1nc2ccc(-c3ocnc3-c3ccccc3F)nc2s1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20120214782A1,CCCO.Cc1cc(F)ccc1I>>CCCOc1ccc(I)c(C)c1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20090239810A1,CC(C)(C)OC(=O)N1CCC(OS(C)(=O)=O)CC1.FC(F)(F)c1ccccc1S>>CC(C)(C)OC(=O)N1CCC(Sc2ccccc2C(F)(F)F)CC1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120172291A1,CN(C)C(OC(C)(C)C)OC(C)(C)C.Cc1cc(C(=O)N[C@H]2CCCCCC=C[C@@H]3C[C@@]3(C(=O)O)NC(=O)[C@@H]3C[C@@H](Oc4nc5ccccc5c5ccccc45)CN3C2=O)no1>>Cc1cc(C(=O)N[C@H]2CCCCCC=C[C@@H]3C[C@@]3(C(=O)OC(C)(C)C)NC(=O)[C@@H]3C[C@@H](Oc4nc5ccccc5c5ccccc45)CN3C2=O)no1,,Cc1ccccc1,,,,val
US20070099929A1,COC(=O)c1cc(Br)sc1NC(=O)OC(C)(C)C.OB(O)c1ccc(F)cc1>>COC(=O)c1cc(-c2ccc(F)cc2)sc1NC(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20080311232A1,CC1(C)[C@@H]2CC[C@@]1(C)[C@@H](OC(=O)CCC(=O)O)C2.OC(CNc1ccccn1)c1ccccc1>>CC1CC(OC(=O)CCC(=O)OCc2ccccc2)C2CC1C2(C)C,,COC(C)(C)C,,CCN(CC)CC,Cl,val
US20090143361A1,COc1ccc([N+](=O)[O-])c(Cl)n1.Cc1c[nH]cn1>>COc1ccc([N+](=O)[O-])c(-n2cnc(C)c2)n1,,CN(C)C=O,,[K+].[OH-],,val
US20100125062A1,OC1CCC(c2cccnc2F)C1.Oc1ccc(Nc2nc3ccccc3s2)cc1>>OC1CCC(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1,,CCOC(C)=O,CN1CCCC1=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05478858,Cc1cc(NC(=S)NCCN)c(C)c2[nH]cnc12>>Cc1cc(NN2C=NCC2)c(C)c2[nH]cnc12,,CO,,Cl,,val
US20020187978A1,Brc1nccs1.CC1(C)OB(c2cccc3[nH]ccc23)OC1(C)C>>c1cc(-c2nccs2)c2cc[nH]c2c1,[Pd],C1CCOC1,,[Na+].[OH-],,val
US20090324581A1,CC(C)(C)OC(=O)N1CCc2c1ccc(O)c2F.FC(F)(F)c1sc(CCl)cc1-c1ccccc1>>CC(C)(C)OC(=O)N1CCc2c1ccc(OCc1cc(-c3ccccc3)c(C(F)(F)F)s1)c2F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06339096B1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.OC1CCNCC1>>OC1CCN(C(c2ccccc2)(c2ccccc2)c2ccccc2)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20050043388A1,COC(=O)c1ccc(C(=O)Nc2ccc(C(=O)O)cc2)cc1.NN>>NNC(=O)c1ccc(C(=O)Nc2ccc(C(=O)O)cc2)cc1,,CCO,O,CC(=O)O,,val
US04748239,COC(=O)C(C(=O)OC)C(Cc1cc(Cl)ccc1N)c1ccc(OC)cc1>>COC(=O)C1C(=O)Nc2ccc(Cl)cc2CC1c1ccc(OC)cc1,,CO,,Cl,C[O-].[Na+],val
US20080119473A1,CC(C)(C)OC(=O)c1cccc(C(=N)N)c1.CN(C)C=CC(=O)c1ccc(F)cc1>>O=C(O)c1cccc(-c2nccc(-c3ccc(F)cc3)n2)c1,,CCO,,[H-].[Na+],,val
US20100273770A1,CC(C)Oc1ccc(-c2nc(-c3ccc4c(c3)CN(C(=O)OC(C)(C)C)C(CCC(=O)O)CO4)no2)cc1Cl.Cl>>CC(C)Oc1ccc(-c2nc(-c3ccc4c(c3)CNC(CCC(=O)O)CO4)no2)cc1Cl.Cl,,Cl,,C1COCCO1,,val
US20150299188A1,COC(=O)c1cc(N)c(C)c([N+](=O)[O-])c1.Cl[Cu]>>COC(=O)c1cc(Cl)c(C)c([N+](=O)[O-])c1,Cl[Cu],C1COCCO1,CC(=O)O,Cl,O=N[O-].[Na+],val
US04920119,NC(=O)c1ccnc(-c2ccccc2)c1N.O=N[O-]>>O=c1[nH]nnc2c(-c3ccccc3)nccc12,,Cl,O,O=C([O-])O.[Na+],,val
US20060160876A1,CCOC(=O)C(=O)c1c[nH]c2c(CC)cc(Br)cc12>>CCc1cc(Br)cc2c(CCO)c[nH]c12,,C1CCOC1,,[BH4-].[Li+],,val
US04229448,Cc1ccc(Br)cc1.Cc1ccc(O)cn1>>Cc1ccc(Oc2ccc(C)nc2)cc1,[Cu],CN(C)C=O,CO,[K],,val
US05585394,CCN(CC)C(=O)Nc1ccc(S(=O)(=O)Cl)cc1.O=c1[nH]c2ccc(Cl)cc2n1-c1ccccc1Cl>>CCN(CC)C(=O)Nc1ccc(S(=O)(=O)n2c(=O)n(-c3ccccc3Cl)c3cc(Cl)ccc32)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20090291079A1,Nc1ccc(-c2nc(N3CCOCC3)nc(N3CC4CCC(C3)O4)n2)cc1.O=C=Nc1ccc(F)cc1>>O=C(Nc1ccc(F)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CC4CCC(C3)O4)n2)cc1,CN(C)c1ccncc1,,,,,val
US06486153B1,C1CCNCC1.CC(=O)Cc1c[nH]c2ccccc12>>CC(Cc1c[nH]c2ccccc12)N1CCCCC1,,ClCCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US20060270652A1,CC(C)c1nc2c(C(=O)NCC3CCN(C(=O)OC(C)(C)C)CC3)cccc2[nH]1>>CC(C)c1nc2c(C(=O)NCC3CCNCC3)cccc2[nH]1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070105852A1,CCOC(=O)c1sc(SC)c(C#N)c1-c1ccc(I)cc1>>CCOC(=O)c1scc(C#N)c1-c1ccc(I)cc1,,CCO,,[BH4-].[Na+],,val
US20080227782A1,CS(=O)(=O)Cl.N#Cc1ccnc(N)c1>>CS(=O)(=O)Nc1cc(C#N)ccn1,,c1ccncc1,,,,val
US20080269219A1,CCOC(=O)CCCc1[nH]c(=O)oc1-c1ccc(F)c2ccccc12.O=P(Cl)(Cl)Cl>>CCOC(=O)CCCc1nc(Cl)oc1-c1ccc(F)c2ccccc12,,c1ccncc1,,,,val
US05981546,CCOC(=O)C[C@H](NC(=O)CN1CC[C@H](CCc2ccc3c(n2)NCCC3)C1=O)c1ccc2c(c1)OCC2>>O=C(O)C[C@H](NC(=O)CN1CC[C@H](CCc2ccc3c(n2)NCCC3)C1=O)c1ccc2c(c1)OCC2,,CCO,O,[Li+].[OH-],,val
US20140162985A1,NC[C@@]12CC[C@](OCc3ccccc3)(C(F)(F)F)C[C@H]1CCCc1cc3c(cnn3-c3ccc(F)cc3)cc12.O=S(=O)(Cl)CCCCl>>O=S1(=O)CCCN1C[C@@]12CC[C@](OCc3ccccc3)(C(F)(F)F)C[C@H]1CCCc1cc3c(cnn3-c3ccc(F)cc3)cc12,,CN(C)C=O,ClCCl,[H-].[Na+],,val
US20020035115A1,CCNCC(=O)O.CCOC(=O)C(=O)Cl>>CCOC(=O)C(=O)NC(CC)C(=O)O,,ClCCCl,,CCN(CC)CC,Cl,val
US04943574,CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]>>CCCCNc1ccc(C(=O)O)cc1N,[Ni],CO,,[H][H],,val
US08658646B2,CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CCC4CN(C(=O)OC(C)(C)C)C4)c4cc(F)ccc34)nc12>>CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CCC4CNC4)c4cc(F)ccc34)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040097413A1,O=C1CC[C@@H](C(=O)N2CCC[C@H]2C(=O)OCc2ccccc2)N1>>O=C1CC[C@@H](C(=O)N2CCC[C@H]2C(=O)O)N1,[Pd],CO,,,,val
US20110207728A1,COc1ccc(C23Cn4cc(C#N)cc4C(=O)N2CCN3C(=O)c2conc2C)cc1>>COc1ccc(C23Cn4cc(CN)cc4C(=O)N2CCN3C(=O)c2conc2C)cc1,[Pd],CO,,Cl,,val
US20060135578A1,COC(=O)c1cccc(-c2nc(COc3ccc(CO)cc3)c(C)o2)c1.O=Cc1cn(-c2ccccc2)nc1O>>COC(=O)c1cccc(-c2nc(COc3ccc(COc4nn(-c5ccccc5)cc4C=O)cc3)c(C)o2)c1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US04199595,CC(C)C(C(=O)Cl)c1ccc(OC(F)(F)C(F)F)cc1.OCc1cccc(Oc2ccccc2)c1>>CC(C)C(C(=O)OCc1cccc(Oc2ccccc2)c1)c1ccc(OC(F)(F)C(F)F)cc1,,CCOCC,,ClCCl,c1ccncc1,val
US05744482,COc1ccccc1CCC(=O)NC[C@@H](Cc1c[nH]c2ccccc12)NC(c1ccccc1)(c1ccccc1)c1ccccc1>>COc1ccccc1CCC(=O)NC[C@H](N)Cc1c[nH]c2ccccc12,,ClCCl,,O=CO,,val
US20140112945A1,COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](Cc4ccccc4Cl)NC(=O)OC(C)(C)C)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl>>COc1ccc(C2=NN(C3CCN(C(=O)[C@H](N)Cc4ccccc4Cl)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl,,C1CCOC1,,,,val
US20050245563A1,COC(=O)c1cc(Cl)ccc1NC(=O)CC(=O)N(C)OC>>CON(C)C(=O)c1c(O)c2cc(Cl)ccc2[nH]c1=O,,CO,,Cl,C[O-].[Na+],val
US20100035883A1,Nc1cccc2c1COC2=O.O=Cc1ccc(C2CCCN2C(=O)OCc2ccccc2)cc1>>O=C1OCc2c(/N=C/c3ccc(C4CCCN4C(=O)OCc4ccccc4)cc3)cccc21,,CC#N,,O=S(=O)([O-])[O-].[Mg+2],,val
US20150065482A1,C#CC(O)(CCO[Si](C)(C)C(C)(C)C)C(=O)OC>>C#CC1(O)CCOC1=O,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100240702A1,CCC[C@@H](C(=O)OC(C)(C)C)n1c(=O)[nH]c2ccccc21.Cc1cccc2scc(C[N+](C)(C)C)c12>>CCC[C@@H](C(=O)OC(C)(C)C)n1c(=O)n(Cc2csc3cccc(C)c23)c2ccccc21,,CCOC(C)=O,CN(C)C=O,[I-].[K+],,val
US20130116285A1,COc1ncccc1B(O)O.N#Cc1ccc(Oc2cnc(C3CC3)c(Cl)c2)c(Br)c1>>COc1ncccc1-c1cc(C#N)ccc1Oc1cnc(C2CC2)c(Cl)c1,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05910504,C#CC(=O)OC.CC(=O)NC[C@H]1CN(c2ccc(N=[N+]=[N-])c(F)c2)C(=O)O1>>COC(=O)c1cn(-c2ccc(N3C[C@H](CNC(C)=O)OC3=O)cc2F)nn1,,c1ccccc1,,,,val
US20110212998A1,Cc1cc(C(=O)OC(C)C)cnc1NC(C)C>>Cc1cc(C(=O)O)cnc1NC(C)C,,Cl,,,,val
US20130310358A1,CC(=O)Cl.COc1ccc(Oc2nc(-c3cncnc3)ncc2NC[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1>>COc1ccc(Oc2nc(-c3cncnc3)ncc2N(C[C@@H]2CCCN2C(=O)OC(C)(C)C)C(C)=O)cc1,,ClCCl,,c1ccncc1,,val
US20150191461A1,CI.COC(=O)C1CC(=O)N(Cc2ccc(OC)cc2OC)C1>>COC(=O)C1(C)CC(=O)N(Cc2ccc(OC)cc2OC)C1,,C1CCOC1,O,[H-].[Na+],,val
US20110144085A1,CI.Cc1ccn2c(-c3ccc4cccc(OCC5(O)CCN(C(=O)OC(C)(C)C)CC5)c4n3)nnc2c1>>COC1(COc2cccc3ccc(-c4nnc5cc(C)ccn45)nc23)CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,[H-].[Na+],,val
US06627651B1,CCOc1ccc(CO)cc1.COC(=O)C1=Cc2cc(O)ccc2S(=O)(=O)CC1>>CCOc1ccc(COc2ccc3c(c2)C=C(C(=O)OC)CCS3(=O)=O)cc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140371219A1,CC(C)(C)OC(=O)N1CCNCC1.O=Cc1cc([N+](=O)[O-])ccc1Cl>>CC(C)(C)OC(=O)N1CCN(Cc2cc([N+](=O)[O-])ccc2Cl)CC1,,ClCCl,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04125732,CC(Br)C(=O)O.Oc1ccc(F)cc1>>CC(Oc1ccc(F)cc1)C(=O)O,,COCCOC,,[H-].[Na+],,val
US20160016908A1,CC(=O)N1c2ccc(C#N)cc2[C@H](Nc2ccc(F)cn2)[C@@H](C)[C@@H]1C1CC1.OO>>CC(=O)N1c2ccc(C(N)=O)cc2[C@H](Nc2ccc(F)cn2)[C@@H](C)[C@@H]1C1CC1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040053986A1,CC(C)(C)OC(=O)N1C[C@@H]2CN(Cc3ccccc3)C[C@@H]2C1.Cl>>CC(C)(C)OC(=O)N1CC2CNCC2C1.Cl,[Pd],CCOC(C)=O,CO,N#N,,val
US20040204586A1,Fc1ccc(CBr)cc1.O=c1[nH]c2ccc(F)cc2c(=O)o1>>O=c1oc(=O)n(Cc2ccc(F)cc2)c2ccc(F)cc12,,CN(C)C=O,,[H-].[Na+],,val
US20150038574A1,CC1(C)CCCCC=C1CO.Oc1cccc(F)c1>>CC1(C)CCCCC=C1COc1cccc(F)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070173519A1,COCCOc1ccc(N(C(=O)OC(C)(C)C)c2c(CCO[Si](C)(C)C(C)(C)C)c(N[C@H]3CCCN(C(=O)OC(C)(C)C)C3)nc3ccnn23)cc1>>COCCOc1ccc(N(C(=O)OC(C)(C)C)c2c(CCO)c(N[C@H]3CCCN(C(=O)OC(C)(C)C)C3)nc3ccnn23)cc1,,C1CCOC1,,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20070249670A1,CC(C)(C)OC(=O)c1cc(Br)sc1NC(=O)Nc1c(Cl)cccc1Cl.OB(O)c1ccc(F)cc1>>CC(C)(C)OC(=O)c1cc(-c2ccc(F)cc2)sc1NC(=O)Nc1c(Cl)cccc1Cl,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20070213341A1,C=C(N=Cc1cc(F)ccc1C)O[Si](C)(C)C.COc1ccc2c(c1)NC(=O)/C2=C\c1cccc(Cl)c1>>COc1ccc2c(c1)NC(=O)C21C(c2cccc(Cl)c2)CC(=O)NC1c1cc(F)ccc1C,,Cc1ccccc1,,,,val
US20110053943A1,Cc1ccc(C2CCN(C(=O)OC(C)(C)C)C2)nc1>>Cc1ccc(C2CCNC2)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070032519A1,COC(=O)c1ccc(F)nc1F.NCc1ccc(Cl)cc1>>COC(=O)c1ccc(NCc2ccc(Cl)cc2)nc1F,,CN(C)C=O,,O,,val
US20090233910A1,COc1cc([N+](=O)[O-])ccc1Cl.Cc1ccc(O)cc1>>COc1cc([N+](=O)[O-])ccc1Oc1ccc(C)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04734407,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC(C(=O)O)c1ccc2csnc2c1>>CC(C)(C)OC(=O)NC(C(=O)O)c1ccc2csnc2c1,,C1COCCO1,O,O=C([O-])O.[Na+],,val
US20150191478A1,CC(C)S(=O)(=O)Cl.CCOC(OCC)c1cc2cncc(N3CCNCC3)c2o1>>CCOC(OCC)c1cc2cncc(N3CCN(S(=O)(=O)C(C)C)CC3)c2o1,,CN(C)C=O,,CCN(CC)CC,,val
US04490369,COc1cc2c(cc1OC)CC(=O)N(CCCCl)CC2>>O=C1Cc2cc(O)c(O)cc2CCN1CCCCl,,ClCCl,,BrB(Br)Br,,val
US20020058635A1,O=C(OC[C@@H]1O[C@H](n2ncc3c(=O)[nH]cnc32)[C@](O)(C(=O)c2ccccc2)[C@]1(O)C(=O)c1ccccc1)c1ccccc1>>O=c1[nH]cnc2c1cnn2[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O,,CO,N,,,val
US20060045953A1,Cc1cccc2c1C(=O)OC2=O.N>>Cc1cccc2c1C(=O)NC2=O,,O,,,,val
US20090281149A1,NC1CCCCC1.O=C(Cl)c1cccc(Br)c1>>O=C(NC1CCCCC1)c1cccc(Br)c1,,ClCCl,,CCN(CC)CC,,val
US20080280889A1,CN(C)c1cc(-c2ccccc2)c(Cl)nn1.O=Cc1ccc(B(O)O)cc1>>CN(C)c1cc(-c2ccccc2)c(-c2ccc(C=O)cc2)nn1,,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090054413A1,Cc1nn(C2CCCC2)c(N)c1C(=O)O.On1nnc2cccnc21>>Cc1nn(C2CCCC2)c(N)c1C(=O)On1nnc2cccnc21,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150133512A1,CCc1nnn(-c2ccc(Br)cc2)c1C(=O)O.C[C@@H](O)c1cccc(C(F)(F)F)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCc1nnn(-c2ccc(Br)cc2)c1NC(=O)O[C@H](C)c1cccc(C(F)(F)F)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20090286765A1,Cn1c(SCC2CC2)nnc1C(N)CC1CC1.O=C(Cl)c1ccc(Cl)cc1Cl>>Cn1c(SCC2CC2)nnc1C(CC1CC1)NC(=O)c1ccc(Cl)cc1Cl,,ClCCl,,CCN(CC)CC,,val
US04870074,ClCC1CN(Cc2ccccc2)CCO1.[N-]=[N+]=[N-]>>[N-]=[N+]=NCC1CN(Cc2ccccc2)CCO1,,O,,CN(C)C=O,,val
US05004843,C=CC1CO1.[Li]CCCC>>CCCCCC=CCO,,CCCCCC,,CCCCO,,val
US04596806,C1CCNCC1.N#Cc1cc(Cl)ccc1[N+](=O)[O-]>>N#Cc1cc(N2CCCCC2)ccc1[N+](=O)[O-],,CN(C)C=O,,O,,val
US20120165343A1,CCCC=O.N#Cc1cc(I)ccc1Br>>CCCC(O)c1ccc(Br)c(C#N)c1,,C1CCOC1,,[Cl-].[NH4+],,val
US20090312388A1,O=C(O)Cc1ccc(N2C(=O)c3c(c(OCC(F)(F)F)c4ccccc4c3OCC(F)(F)F)C2O)c(Cl)c1>>O=C(O)Cc1ccc(N2Cc3c(c(OCC(F)(F)F)c4ccccc4c3OCC(F)(F)F)C2=O)c(Cl)c1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20130116243A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)-n3c(n[nH]c3=O)CO4)cc2)CCC1.N#CCBr>>CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)-n3c(nn(CC#N)c3=O)CO4)cc2)CCC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04166127,CCOc1ccc2c(c1)C(=O)Cc1c(Cl)cccc1S2>>CCOc1ccc2c(c1)C(O)Cc1c(Cl)cccc1S2,,CO,ClC(Cl)Cl,O,,val
US04638067,CC1COc2c(F)c(F)cc3c(=O)c(C(=O)O)cn1c23.CNCC1CCNC1>>CNCC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2OCC4C)C1,,CC#N,,,,val
US20130217664A1,CCB(CC)CC.N#Cc1cc(F)c(N)c(I)c1>>CCc1cc(C#N)cc(F)c1N,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120258952A1,C=O.CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(C(=O)N5CCNCC5)ccn34)c12.Cl.Cl>>CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(C(=O)N5CCN(C)CC5)ccn34)c12.Cl.Cl,,CO,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20060135578A1,COc1cc(C=O)ccc1O.ClCc1csc(N2CCOCC2)n1>>COc1cc(C=O)ccc1OCc1csc(N2CCOCC2)n1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050032873A1,CC=O.NC(=O)c1cccc2c1CC(NCCCc1c[nH]c3ccc(F)cc13)CO2>>CCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2cccc(C(N)=O)c2C1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20140200227A1,CC(C)(C)OC(=O)N[C@H]1CCCN(c2c([N+](=O)[O-])cnc3c2CCCN3)C1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@H]1CCCN(c2c([N+](=O)[O-])cnc3c2CCCN3C(=O)OC(C)(C)C)C1,CN(C)c1ccncc1,CC#N,,,,val
US20140315917A1,COC[C@H](C)NC(=O)NCCCl>>COC[C@@H](C)N1CCNC1=O,,C1CCOC1,,CCOC(C)=O,[H-].[Na+],val
US20150148332A1,Cc1ncc(C)n2nc(/C=C/c3nc(N4CCCC4C)nn3C)nc12>>Cc1ncc(C)n2nc(CCc3nc(N4CCCC4C)nn3C)nc12,[Pd],CO,,,,val
US20090270443A1,CCOC(CCNC(=O)O)OCC.CCOCc1nc2c(Cl)nc(C)c(C)c2n1N.CCOCc1nc2c(Cl)nc(C)c(C)c2n1NC(C)(C)C>>CCOCc1nc2c(Cl)nc(C)c(C)c2n1N=CCCNC(=O)OC(C)(C)C,,CC#N,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20030144175A1,CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)NC1CCCNCC1O.O=S(=O)(Cl)c1cccnc1>>CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)NC1CCCN(S(=O)(=O)c2cccnc2)CC1=O,,CCOC(C)=O,ClCCl,CCN(CC)CC,CO,val
US04628115,CCCc1c(O)ccc(C(C)=O)c1O.ClCCCC#CCOC1CCCCO1>>CCCc1c(OCCCC#CCO)ccc(C(C)=O)c1O,,CC(C)=O,CN(C)C=O,[I-].[K+],,val
US04160829,C=[N+]=[N-].Cc1noc(CC(=O)O)n1>>COC(=O)Cc1nc(C)no1,,CCOCC,O,,,val
US05206240,CN.CSC(=NCc1ccc(CCO)cc1)NC#N>>CNC(=NCc1ccc(CCO)cc1)NC#N,,CO,,,,val
US20130261104A1,C[Si](C)(C)CCOCn1c2cnc(C#N)cc2c2cc(-c3ccc(CN4C5CCC4CC(OC(=S)n4ccnc4)C5)cc3)cnc21>>C[Si](C)(C)CCOCn1c2cnc(C#N)cc2c2ccc(-c3ccc(CN4C5CCCC4CC5)cc3)nc21,,Cc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US20080119442A1,N#Cc1ccc2c([N+](=O)[O-])cc3c(c2c1)C(CCl)CN3.O=S(=O)(O)O>>NC(=O)c1ccc2c([N+](=O)[O-])cc3c(c2c1)C(CCl)CN3,,O,,Cl,N,val
US20140051679A1,BrC1CCCC1.CCOC(=O)Cc1ccccc1F>>O=C(O)C(c1ccccc1F)C1CCCC1,,CN(C)C=O,,[H-].[Na+],,val
US06211199B1,CCN(C(C)C)C(C)C.CCOCCn1c(NC2CCN(CCC3(c4ccccc4)CCNC3)CC2)nc2ccccc21.COc1ccc(Cn2ccnn2)cc1C(=O)Cl>>CCOCCn1c(NC2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(Cn5cnnn5)ccc4OC)C3)CC2)nc2ccccc21,,C1CCOC1,CCOC(C)=O,,,val
US03947434,CSc1cccc(N)c1.Cc1cc(Nc2ccccc2)c2c(ccc3nc[nH]c32)n1.Cl>>CSc1cccc(Nc2cc(C)nc3ccc4nc[nH]c4c23)c1.Cl,,CN(C)C=O,,,,val
US20140194431A1,CS(=O)(=O)Cl.OCC1(c2ccccn2)CCCC1>>CS(=O)(=O)OCC1(c2ccccn2)CCCC1,,CCCCCC,ClCCl,CCN(CC)CC,CCOC(C)=O,val
US04032661,CC1CCC(C)C(SC(C)C)C1.OO>>CC1CCC(C)C(S(=O)C(C)C)C1,,CC(=O)O,,,,val
US20040142947A1,Cc1ccc(S(=O)(=O)n2ccc3c(-c4cccnc4)ncnc32)cc1.II>>Cc1ccc(S(=O)(=O)n2c(I)cc3c(-c4cccnc4)ncnc32)cc1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US05284837,C=C(CC(=O)OC)C(=O)OC.Nc1ncnc2nc[nH]c12>>COC(=O)CC(Cn1cnc2c(N)ncnc21)C(=O)OC,,CN(C)C=O,,[H-].[Na+],,val
US09441008B2,CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](OS(=O)(=O)C(F)(F)F)[C@H](n2c(=O)sc3c(OS(=O)(=O)C(F)(F)F)nc(N)nc32)O1.[C-]#N>>CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](C#N)[C@H](n2c(=O)sc3c(=O)[nH]c(N)nc32)O1,,CN(C)C=O,,CCOC(C)=O,,val
US20080300256A1,CCOC(=O)CN1CCCCC1=NC#N>>CCOC(=O)c1c(N)nc2n1CCCC2,,CCO,,C,C[O-].[Na+],val
US06235740B1,CC(=O)O.COc1cc(N)cc(OC)c1>>COc1cc(NC(C)=O)cc(OC)c1,,CC(=O)O,O,CC(=O)OC(C)=O,,val
US20100311748A1,COC(=O)c1ccc(C#Cc2ccccn2)cc1>>O=C(O)c1ccc(C#Cc2ccccn2)cc1,,CO,,O,[Li+].[OH-],val
US06924384B2,Cl[SiH](Cl)Cl.Fc1c(F)c(F)c([Mg]Br)c(F)c1F>>Cl[SiH](Cl)Cl.Fc1c(F)c(F)c([Mg]Br)c(F)c1F,,CCOCC,,,,val
US20020045759A1,COc1cccc(S)c1.O=C1c2ccccc2C(=O)N1CCCBr>>COc1cccc(SCCCN2C(=O)c3ccccc3C2=O)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US03947417,NCCO.O=C(O)c1nc(CCl)n(-c2ccc(Cl)cc2C(=O)c2ccccc2)n1>>O=C(NCCO)c1nc(CCl)n(-c2ccc(Cl)cc2C(=O)c2ccccc2)n1,,C1CCOC1,,CCN(CC)CC,CCOC(=O)Cl,val
US20160168090A1,C=O.O=C(NCC1(O)CCC(F)(F)CC1)c1cn(C2CNC2)c2cccc(Cl)c12>>CN1CC(n2cc(C(=O)NCC3(O)CCC(F)(F)CC3)c3c(Cl)cccc32)C1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04931574,COC(=O)C1CCc2cc(C(C)=O)c(OCCCCCO)cc2O1.CS(=O)(=O)Cl>>COC(=O)C1CCc2cc(C(C)=O)c(OCCCCCOS(C)(=O)=O)cc2O1,,CCCCCC,CCOC(C)=O,CCN(CC)CC,,val
US20110201635A1,CC(C)(C)CC1CNC(c2cccc(Cl)c2F)C12C(=O)Nc1cc(Cl)ccc12.COC(=O)c1ccc(CO)cc1.O=C(Cl)Cl>>COC(=O)c1ccc(COC(=O)N2CC(CC(C)(C)C)C3(C(=O)Nc4cc(Cl)ccc43)C2c2cccc(Cl)c2F)cc1,,C1CCOC1,Cc1ccccc1,CCN(CC)CC,,val
US20040102324A1,CCOC(=O)c1cncc(C)c1N=[N+]=[N-]>>CCOC(=O)c1cncc(C)c1N,[Pd],CCO,,[H][H],,val
US04551460,O=S(Cl)Cl.OCCCCCCc1cnc2ccccc2c1>>ClCCCCCCc1cnc2ccccc2c1,,ClCCl,,,,val
US05439917,Cc1c(Cl)[nH]c2ncccc12.O=C(CCl)c1ccc(F)cc1>>Cc1c2cccn(CC(=O)c3ccc(F)cc3)c-2nc1Cl.Cl,,CC#N,,,,val
US04193921,C1=COCCC1.CCOCC.COC(=O)C[C@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)C[C@H](O)[C@]4(C)[C@H]3CC[C@]12C.c1ccccc1>>COC(=O)C[C@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC5CCCCO5)C[C@H](OC5CCCCO5)[C@]4(C)[C@H]3CC[C@]12C,,CCOCC,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20130244999A1,CC1Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1.CCOC(=O)c1cnc(Br)s1>>CC1Cc2ccc(-c3ncc(C(=O)O)s3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1,,C1COCCO1,O,ClCCl,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20140296313A1,CCC(c1nc(-c2ccc(OC(F)(F)F)cc2)c[nH]1)C1(NS(=O)C(C)(C)C)COC1>>CCC(c1nc(-c2ccc(OC(F)(F)F)cc2)c[nH]1)C1(N)COC1,,C1COCCO1,CO,Cl,O=C([O-])O.[Na+],val
US04371536,CCOC(=O)C1NCc2[nH]c3ccccc3c2C1C>>CCOC(=O)c1ncc2[nH]c3ccccc3c2c1C,,Cc1ccccc1C,,,,val
US20100152190A1,COC(=O)CCc1ccc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(c3ccc(Cl)cc3F)[C@H]2c2cccc(Cl)c2F)cc1>>CC(C)(C)C[C@@H]1N[C@@H](C(=O)Nc2ccc(CCC(=O)O)cc2)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F,,C1CCOC1,O,Cl,[Li+].[OH-],val
US05084463,CN(CCCOc1ccc([N+](=O)[O-])cc1)Cc1cnc2ccccc2n1>>CN(CCCOc1ccc(N)cc1)Cc1cnc2ccccc2n1,O=[Pt]=O,CCO,,,,val
US05726306,CC(=O)OC(C)=O.O=C(O)CNC[C@H]1O[C@H](c2ccccc2Cl)c2cc(Cl)ccc2N(Cc2ccccc2)C1=O>>CC(=O)N(CC(=O)O)C[C@H]1O[C@H](c2ccccc2Cl)c2cc(Cl)ccc2N(Cc2ccccc2)C1=O,,CO,,CCN(CC)CC,,val
US20070072862A1,Cc1ccc(C(=O)Cl)cc1I.Nc1cc(C(F)(F)F)ccc1F>>Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccc2F)cc1I,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040248888A1,CC(C)c1nc(I)cn1-c1ccc(F)cc1.C[Si](C)(C)C#Cc1ccnc(Cl)c1.O=C(O)/C=C/C(=O)O>>CC(C)c1nc(C#Cc2ccnc(Cl)c2)cn1-c1ccc(F)cc1.O=C(O)/C=C/C(=O)O,,CO,,,,val
US20080021217A1,COC(=O)CCC1(c2ccc(OC)cc2)OCCO1.NN>>COc1ccc(C2(CCC(=O)NN)OCCO2)cc1,,CO,,O,,val
US20040019051A1,NCCCNC1(CO)CCN(Cc2ccccc2)CC1.O=C(n1ccnc1)n1ccnc1>>O=C1NCCCN1C1(CO)CCN(Cc2ccccc2)CC1,,C1CCOC1,,,,val
US20140371247A1,CC(C)(C)OC(=O)N1CCC2(CC1)CO2.Oc1ncnc2ccccc12>>CC(C)(C)OC(=O)N1CCC(O)(Cn2cnc3ccccc3c2=O)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050014727A1,COc1ccc(C(=O)Cl)cc1.COc1ccccc1OC>>COc1ccc(C(=O)c2ccc(OC)c(OC)c2)cc1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04189485,CNc1ncnc2nc[nH]c12.Fc1cccc(Cl)c1CCl>>CNc1ncnc2c1ncn2Cc1c(F)cccc1Cl,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20120142717A1,COC(=O)CCn1ccc2ccccc21.COC=O>>COC(=O)/C(=C\O)Cn1ccc2ccccc21,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20130196965A1,C=CCCBr.COC(=O)[C@@H]1C[C@H](F)CN1>>C=CCCN1C[C@@H](F)C[C@H]1C(=O)OC,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20150232464A1,Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(C#N)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.[N-]=[N+]=[N-].[NH4+]>>Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1nn[nH]n1,,CCOC(C)=O,CN(C)C=O,O,[Cl-].[Na+],val
US20150133432A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2cc(-c3ccc(O)cc3)nc3c2c(C2CC2)nn3C2CCCCO2)CC1>>CC(C)(C)OC(=O)N1CCN(Cc2cc(-c3ccc(O)cc3)nc3c2c(C2CC2)nn3C2CCCCO2)CC1,,C1CCOC1,,B,CSC,val
US20030119890A1,CC(C)(C)CNC(=S)Nc1ccc(F)cc1.CCOC(=O)C(=O)Cl>>CC(C)(C)CN1C(=O)C(=O)N(c2ccc(F)cc2)C1=S,,ClCCl,,,,val
US20090137773A1,CN(C)CCCNS(=O)(=O)CCC(CC(F)(C(F)(F)F)C(F)(F)F)CC(F)(C(F)(F)F)C(F)(F)F.OO>>CN(C)CCC[NH+]([O-])S(=O)(=O)CCC(CC(F)(C(F)(F)F)C(F)(F)F)CC(F)(C(F)(F)F)C(F)(F)F,,O,,CCO,,val
US04797399,Nc1cc(Cl)cnc1S.O=C(Cl)Cl>>O=c1[nH]c2cc(Cl)cnc2s1,,Cc1ccccc1,,Cl,[Na+].[OH-],val
US20050222045A1,CC(=O)Cl.CC(=O)c1ccc2c(c1)Nc1ccccc1S2>>CC(=O)c1ccc2c(c1)N(C(C)=O)c1ccccc1S2,,Cc1ccccc1,,,,val
US04039316,CCCCOC(=O)Cl.CO/C(C)=C\C(=O)Nc1cccc(N)c1>>CCCCOC(=O)Nc1cccc(NC(=O)/C=C(/C)OC)c1,,CCN(CC)CC,,C1CCOC1,,val
US04421693,CC(C)OC(=O)CNCC(=O)[O-].ClSCl.c1ccncc1>>CC(C)OC(=O)CN(CC(=O)OC(C)C)SCl,,ClC(Cl)(Cl)Cl,,,,val
US05268389,CC1=C(C(=O)O)SCCO1.CCOC(=O)c1cccc(N)c1>>CCOC(=O)c1cccc(NC(=O)C2=C(C)OCCS2)c1,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20090247746A1,CN(c1cccc2cc(-c3nccs3)[nH]c12)S(=O)(=O)c1ccsc1CO>>CN(c1cccc2cc(-c3nccs3)[nH]c12)S(=O)(=O)c1ccsc1C=O,,CC#N,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20050244332A1,CI.Cc1c(S)oc2ccccc2c1=O>>CSc1oc2ccccc2c(=O)c1C,,CC(C)=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20060276655A1,N#CC1CCC(SCC2CC2)CC1.O=CC1CC1>>N#CC1(C(O)C2CC2)CCC(SCC2CC2)CC1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20080293749A1,NCc1ccc(F)cc1N.O=C1C=CC(=O)N1>>Nc1cc(F)ccc1CNC1CC(=O)NC1=O,,CCOC(C)=O,,,,val
US20160108035A1,CI.OCc1ccc2nccc(Cl)c2c1>>COCc1ccc2nccc(Cl)c2c1,,C1CCOC1,,[H-].[Na+],,val
US20090264437A1,CC(C)(C)c1nc(O)cc(C2CC2)n1.O=P(Cl)(Cl)Cl>>CC(C)(C)c1nc(Cl)cc(C2CC2)n1,,CN(C)C=O,Cc1ccccc1,,,val
US20120053173A1,Cc1c(C(=O)C2CCCCC2)oc2ccc(OCc3ccccc3)cc12>>Cc1c(C(=O)C2CCCCC2)oc2ccc(O)cc12,,C1CCOC1,CCO,,,val
US05756528,CC(C)(C)OC(=O)N[C@@H](CCS(C)(=O)=O)CNCc1cccc(Cl)c1.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)N[C@@H](CCS(C)(=O)=O)CN(Cc1cccc(Cl)c1)C(=O)OCc1ccccc1,,CCOC(C)=O,ClCCl,CCN(CC)CC,[Cl-].[NH4+],val
US20090286778A1,CC(C)(C)OC(=O)Nc1cccc(CCc2cccc(N)c2)n1.Fc1cnc(Cl)nc1Cl>>CC(C)(C)OC(=O)Nc1cccc(CCc2cccc(Nc3nc(Cl)ncc3F)c2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060025430A1,COCC(=O)Cl.Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1>>COCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20140242028A1,O=[N+]([O-])c1cc(Cl)c(Sc2ccccc2C(F)(F)F)c(Cl)c1>>Nc1cc(Cl)c(Sc2ccccc2C(F)(F)F)c(Cl)c1,[Fe],O,,CO,[Cl-].[NH4+],val
US20060178386A1,CC(C)(C)OC(=O)NCC=O.NC(=O)c1c(Cl)cccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)NCC1NC(=O)c2c(Cl)cccc2N1,[Fe],CC(=O)O,,,,val
US20070060607A1,CCOC(=O)c1cnc(Cl)c2c(COc3cccc(NS(=O)(=O)c4ccc(Cl)cc4)c3)csc12.N>>CCOC(=O)c1cnc(N)c2c(COc3cccc(NS(=O)(=O)c4ccc(Cl)cc4)c3)csc12,,CC(C)O,,,,val
US20120258952A1,CCc1nn(Cc2ccccc2)c2ccc(Cl)c(N)c12.COCCOc1ccn2c(C(=O)O)cnc2c1>>CCc1nn(Cc2ccccc2)c2ccc(Cl)c(NC(=O)c3cnc4cc(OCCOC)ccn34)c12,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US04016184,CCCCC[C@H](O)/C=C/[C@H]1C(=O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O>>CCCCC[C@H](O)/C=C/[C@H]1C(=O)C[C@H](O)[C@@H]1CCCCCCC(=O)O,[Pd],CCOC(C)=O,,[H][H],,val
US20160007602A1,COC(=O)[C@@H](CCC(C)C)[C@H](C)O>>CC(C)CC[C@H](CO)[C@H](C)O,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120214786A1,Nc1cc(OCC(F)F)c(C(=O)N[C@@H]2CC[C@@H](C(F)(F)F)CC2)cc1[N+](=O)[O-]>>Nc1cc(OCC(F)F)c(C(=O)N[C@@H]2CC[C@@H](C(F)(F)F)CC2)cc1N,[Pd],,,,,val
US20100190761A1,BrC(Br)(Br)Br.CC(C)C(C)(c1ccc(OCc2ccccn2)cc1)c1ccc(-c2noc(CO)n2)cc1>>CC(C)C(C)(c1ccc(OCc2ccccn2)cc1)c1ccc(-c2noc(CBr)n2)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090048326A1,CCC(=O)N1C[C@@H]2C[C@@H](c3ccc(NS(=O)(=O)c4ccc(OC(F)(F)F)cc4)cc3)[C@@H]2C1>>O=S(=O)(Nc1ccc(C2CC3CNCC32)cc1)c1ccc(OC(F)(F)F)cc1,,CCCCO,,Cl,,val
US20070219183A1,CC#CCBr.O=C(Nc1cccc(C2=CCNc3ccnn32)c1)c1cccc(C(F)(F)F)c1>>CC#CCN1CC=C(c2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)n2nccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20030013720A1,CC(C)(C)OC(=O)N(CC=O)c1ccc(F)c(F)c1.CN1CCC(CN)(c2ccc(I)cc2)CC1>>CN1CCC(CNCCN(C(=O)OC(C)(C)C)c2ccc(F)c(F)c2)(c2ccc(I)cc2)CC1,,CO,,[BH4-].[Na+],,val
US20070287699A1,CC(c1ccc(C(F)(F)F)cc1)n1cc(C#N)c(=O)c2cc(F)c(N3CCOCC3)cc21.NO>>CC(c1ccc(C(F)(F)F)cc1)n1cc(C(=N)NO)c(=O)c2cc(F)c(N3CCOCC3)cc21,,CO,O,,,val
US20120322841A1,Cc1cc(C#N)ccc1C1CCC(C)(C)C(=O)/C1=C\N(C)C.Cl.NN>>Cc1cc(C#N)ccc1C1CCC(C)(C)c2n[nH]cc21.Cl,CC(=O)O,CCO,,,,val
US05837702,CC1(C)Oc2ccc(C#N)cc2[C@H]2O[C@H]21.CCOC(=O)CN(c1ccccc1)[C@H]1c2cc(C#N)ccc2OC(C)(C)[C@@H]1O.CO>>CC1(C)Oc2ccc(C#N)cc2[C@H](N(Cc2ccco2)c2ccccc2)[C@H]1O,,CO,,,,val
US20060135578A1,COC(=O)c1cccc(-c2nc(COc3ccc(CCl)cc3OC)c(C)o2)c1.O=Cc1cn(-c2ccccc2)nc1O>>COC(=O)c1cccc(-c2nc(COc3ccc(CON4CC(C=O)=CN4c4ccccc4)cc3OC)c(C)o2)c1,,O,,CN(C)C=O,[H-].[Na+],val
US06667303B1,FC(F)(F)CCCI.O=C1Nc2ccc(Br)c3cccc1c23>>O=C1c2cccc3c(Br)ccc(c23)N1CCCC(F)(F)F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05081131,CC(CCN)n1ccnc1.CN(C)S(=O)(=O)c1ccc2c3c(cccc13)C(=S)N2>>CC(CCNC1=Nc2ccc(S(=O)(=O)N(C)C)c3cccc1c23)n1ccnc1,,CCO,,,,val
US20140194403A1,CC(C)(C)[Si](C)(C)O[C@H]1CN=C(c2cccc(F)c2)C1>>O[C@H]1CN[C@@H](c2cccc(F)c2)C1,,CO,,CC(=O)O,[BH4-].[Na+],val
US04994485,CI.CSc1sc(C#N)c(O)c1C#N>>COc1c(C#N)sc(SC)c1C#N,,CC#N,,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US05344830,CC(C)(C)OC(=O)NCCN.NC(=O)CI.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)NCCN(CC(N)=O)C(=O)OCc1ccccc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20070203099A1,CCOC(=O)C(Oc1cccc2c1ccn2C(=O)OCc1ccccc1)C(=O)OCC>>CCOC(=O)C(Oc1cccc2[nH]ccc12)C(=O)OCC,[Pd],CCO,,[H][H],,val
US20100331326A1,Nc1cccnc1.O=C=NCCCl>>O=C(NCCCl)Nc1cccnc1,,Cc1ccccc1,,CCOC(C)=O,,val
US20130274268A1,CC(C)(C)OC(=O)N1CCC(O)CC1.Cn1cc(Br)c2ncnc(Cl)c21>>Cn1cc(Br)c2ncnc(OC3CCN(C(=O)OC(C)(C)C)CC3)c21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050222410A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(-c2cccnc2)cn1>>Nc1ccccc1NC(=O)c1ccc(-c2cccnc2)cn1,,C1COCCO1,,Cl,,val
US04231784,CNc1nc(N)nc(OC)n1.O=C=NS(=O)(=O)c1ccccc1Cl>>CNc1nc(NC(=O)NS(=O)(=O)c2ccccc2Cl)nc(OC)n1,,CC#N,,,,val
US20110172193A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1c(N2CCCC(=C(F)CN)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12>>COc1c(N2CCCC(=C(F)CNC(=O)OC(C)(C)C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,,ClCCl,,CCN(CC)CC,,val
US04584008,CC(C)(C)OC(=O)CBr.c1nc[nH]n1>>CC(C)(C)OC(=O)Cn1cncn1,,CCO,,C,C[O-].[Na+],val
US20070167443A1,CON(C)C(=O)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O.Clc1ccc([Mg]Br)s1>>O=C(c1ccc(Cl)s1)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O,,C1CCOC1,,,,val
US04329347,O=C1CCc2c(cccc2OCCCCS(=O)(=O)c2ccccc2)N1>>O=c1ccc2c(OCCCCS(=O)(=O)c3ccccc3)cccc2[nH]1,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20060089392A1,COC(=O)c1ccc(O)c(F)c1.O=C1CCC(=O)N1Br>>COC(=O)c1cc(F)c(O)c(Br)c1,,C1CCOC1,CCOC(C)=O,,,val
US20100121048A1,CC(C)(C)OC(=O)N1CCCCC1Cn1cnc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2Cc2ccccc2)c1-c1ccccc1>>O=C(c1ncn(CC2CCCCN2)c1-c1ccccc1)N1CCN(Cc2ccccc2)C[C@H]1Cc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120295845A1,Cc1c(Cl)ncnc1O[C@H]1CCN(C(=O)OC(C)(C)C)C[C@H]1F.c1cc2n(n1)CCN2>>Cc1c(O[C@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2F)ncnc1N1CCn2nccc21,,CN1CCCC1=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06093732,CCOC(=O)c1cnc2c(F)cc(SCc3ccccc3)cc2c1O.NCc1ccc(Cl)cc1>>O=C(NCc1ccc(Cl)cc1)c1cnc2c(F)cc(SCc3ccccc3)cc2c1O,,CO,ClC(Cl)Cl,,,val
US20110251173A1,C[C@H](CNc1ccc(OCc2ccccc2)c(F)c1)O[Si](C)(C)C(C)(C)C.O=C(Cl)c1c(Cl)ncnc1Cl>>C[C@H](CN(C(=O)c1c(Cl)ncnc1Cl)c1ccc(OCc2ccccc2)c(F)c1)O[Si](C)(C)C(C)(C)C,,C1CCOC1,,CCN(CC)CC,,val
US20040220169A1,CC1CCC(C)N1.O=C(NCc1nc2cc(Cl)ccc2[nH]1)c1ccc(C(=O)O)c(Cl)c1>>CC1CCC(C)N1C(=O)c1ccc(C(=O)NCc2nc3cc(Cl)ccc3[nH]2)cc1Cl,,CS(C)=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20020006948A1,CC(C)(C)OC(=O)CCOCCOc1ccc2nc(-c3ccccc3)n(-c3ccccc3)c2c1>>O=C(O)CCOCCOc1ccc2nc(-c3ccccc3)n(-c3ccccc3)c2c1,,O,O=C(O)C(F)(F)F,,,val
US20080139539A1,NC(=O)CC1(O)CCN(Cc2ccccc2)CC1>>NCCC1(O)CCN(Cc2ccccc2)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150299121A1,CCN(CC)S(F)(F)F.O=C(OCc1ccccc1)C1CCC(O)C1>>O=C(OCc1ccccc1)C1CCC(F)C1,,ClCCl,,,,val
US05665737,COc1ccc(CC(=O)Nc2c(O)cccc2O)cc1OC1CCCC1>>COc1ccc(Cc2nc3c(O)cccc3o2)cc1OC1CCCC1,,Cc1ccccc1C,O,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US04973592,NCCNC(c1ccccc1)(c1ccccc1)c1ccccc1.OC(CCCl)(c1ccccc1)C1CCCCC1>>OC(CCNCCNC(c1ccccc1)(c1ccccc1)c1ccccc1)(c1ccccc1)C1CCCCC1,,CCCCO,O,O=C([O-])[O-].[Na+].[Na+],,val
US05246965,CCO.N#Cc1ccc(O)cc1>>CCOC(=N)c1ccc(O)cc1,,ClCCl,,Cl,,val
US20150252036A1,CCOC(=O)Cc1ccc(O)c(Br)c1.O=S(=O)(OCC(F)F)C(F)(F)F>>CCOC(=O)Cc1ccc(OCC(F)F)c(Br)c1,,C1CCOC1,,[H-].[Na+],,val
US20080096877A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.NC(=O)c1cc2ccc(Cl)c(NS(=O)(=O)c3cccs3)c2[nH]1>>NC(=S)c1cc2ccc(Cl)c(NS(=O)(=O)c3cccs3)c2[nH]1,,C1CCOC1,,,,val
US20120190700A1,COC(OC)N(C)C.O=C1Cc2cc(F)ccc2N1>>CN(C)/C=C1/C(=O)Nc2ccc(F)cc21,,C1CCOC1,,O,,val
US20160068551A1,Brc1cncc(CNCc2ccccc2)c1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N(Cc1ccccc1)Cc1cncc(Br)c1,,ClCCl,,,,val
US20160009744A1,CC(C)[Si](O[C@H]1C[C@H](Nc2ncncc2C(=O)c2cc(CCc3ccccc3)cs2)C[C@@H]1CO)(C(C)C)C(C)C.NS(=O)(=O)Cl>>NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ncncc2C(=O)c2cc(CCc3ccccc3)cs2)C[C@@H]1O,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20090198070A1,CC(C)(C)[C@H](N)CO.N#Cc1ccc(C(=O)O)cc1>>CC(C)(C)[C@H]1COC(c2ccc(C#N)cc2)=N1,,Clc1ccccc1,,,,val
US20090036542A1,BrCc1ccccc1.OCCCCCCCCCCCCBr>>BrCCCCCCCCCCCCOCc1ccccc1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20130023526A1,COc1cc(CNC(=O)c2cc(C3=NOC(c4ccc(C(=O)O)cc4)C3)nc(C)n2)ccc1F.N>>COc1cc(CNC(=O)c2cc(C3=NOC(c4ccc(C(N)=O)cc4)C3)nc(C)n2)ccc1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US03943141,Cc1ccc2c(=O)c(C(=O)Nc3nnn[nH]3)cn(CCOC=O)c2n1>>Cc1ccc2c(=O)c(C(=O)Nc3nnn[nH]3)cn(CCO)c2n1,,[Na+],[OH-],Cl,,val
US20070232627A1,Cc1ccc(N)cc1.O=C(Cl)c1ccc(F)c([N+](=O)[O-])c1>>Cc1ccc(NC(=O)c2ccc(F)c([N+](=O)[O-])c2)cc1,,C1CCOC1,O,CCN(C(C)C)C(C)C,,val
US20050026944A1,CCN(CC)CC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12>>CCN(CC)CCCc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12,[Pd],CO,,,,val
US06127361,COc1ccc(CCN2CCC[C@@H](Cl)C2)cc1.c1ccc2c(c1)COc1ccccc1N2>>COc1ccc(CCN2CCC[C@H]2CN2c3ccccc3COc3ccccc32)cc1,,CS(C)=O,,[H-].[Na+],,val
US20090170836A1,C1CNCCNC1.O=[N+]([O-])c1ccc(F)cc1>>O=[N+]([O-])c1ccc(N2CCCNCC2)cc1,,ClCCl,,,,val
US20030134847A1,CCOC(=O)CCP(=O)(OCC)OCC.COc1ccc2c(n1)c(C=O)c1n2Cc2ccccc2-1>>CCOC(=O)CC=Cc1c2n(c3ccc(OC)nc13)Cc1ccccc1-2,,C1CCOC1,,[H-].[Na+],,val
US20150232460A1,COC(=O)C1CCCC1(C)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NC1(C)CCCC1C(=O)O,,C1CCOC1,O,[Li+].[OH-],,val
US07855292B2,COC(=O)c1cc(Cl)c(Cl)cc1N>>Nc1cc(Cl)c(Cl)cc1C(=O)O,,C1CCOC1,,O,[Li+].[OH-],val
US20060030584A1,COC(=O)c1ccc2cccnc2n1>>COC(=O)C1CCc2cnccc2N1,[Pd],CO,,,,val
US06110962,COC(=O)CBr.Oc1c(Br)cc(-c2c3ccccc3c(Br)c3sc4ccccc4c23)cc1Br>>COC(=O)COc1c(Br)cc(-c2c3ccccc3c(Br)c3sc4ccccc4c23)cc1Br,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130150326A1,Brc1cn[nH]c1.FC(F)(F)CI>>FC(F)(F)Cn1cc(Br)cn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130317065A1,COC(=O)c1cccc(Cc2c(-c3ccccc3)[nH]c3cc(OC)ccc23)n1>>COc1ccc2c(Cc3cccc(CO)n3)c(-c3ccccc3)[nH]c2c1,,C1CCOC1,CO,[BH4-].[Na+],[Cl-].[NH4+],val
US20040127574A1,CCOC(=O)c1c(-c2ccccc2)oc(C)c1-c1ccc(F)cc1.O=C1CCC(=O)N1Br>>CCOC(=O)c1c(-c2ccccc2)oc(CBr)c1-c1ccc(F)cc1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20110251190A1,COc1ccc(Br)c(C(=O)O)c1F.Oc1ccc(Br)cc1F>>COc1ccc(Oc2ccc(Br)cc2F)c(C(=O)O)c1F,,Cc1ccccc1,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US03998879,CC(=O)CC(=O)Cc1ccccc1.Cc1ccc(S(=O)(=O)N=C=O)cc1>>CC(=O)C(C(=O)Cc1ccccc1)C(=O)NS(=O)(=O)c1ccc(C)cc1,,c1ccccc1,,,,val
US20100305131A1,CCOC(=O)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)OC(C)(C)C.O=C1CCC(=O)O1>>CCOC(=O)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US05834463,O=C(Br)CBr.O=C1[C@H]2CCC[C@H]2Nc2ccccc2N1Cc1ccccc1F>>O=C1[C@H]2CCC[C@H]2N(C(=O)CBr)c2ccccc2N1Cc1ccccc1F,,CCCCCC,CCOC(C)=O,,,val
US20120220572A1,CC1(C)CNCc2cc([N+](=O)[O-])ccc21.CCBr>>CCN1Cc2cc([N+](=O)[O-])ccc2C(C)(C)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150274673A1,Cc1c(B2OC(C)(C)C(C)(C)O2)cc(Cl)c2c1CCCO2>>Cc1c(B2OC(C)(C)C(C)(C)O2)ccc2c1CCCO2,[Pd],CO,,O=C[O-].[NH4+],,val
US05387727,Fc1cc(F)c(F)c(F)c1F.[Li]C(C)(C)C>>[Li]c1c(F)c(F)c(F)c(F)c1F,,CCCCC,,CCOCC,,val
US20060247238A1,CCOC(=O)CN1CC[C@@H](N)C1.O=S(=O)(Cl)c1ccc(Cl)s1>>CCOC(=O)CN1CC[C@@H](NS(=O)(=O)c2ccc(Cl)s2)C1,,C1CCOC1,CCOC(C)=O,Cl,Cl,val
US20130184271A1,COc1ccc2[nH]c3ccccc3c2c1.O=C1CCC(=O)N1Br>>COc1ccc2[nH]c3ccc(Br)cc3c2c1,,CN(C)C=O,,O,,val
US20070249670A1,CC(C)(C)OC(=O)[C@@H](NC(=O)c1ccc(-c2ccccc2)cc1N)C1CCCCC1.O=C=Nc1c(Cl)cc(OC(F)(F)F)cc1Cl>>CC(C)(C)OC(=O)[C@@H](NC(=O)c1ccc(-c2ccccc2)cc1NC(=O)Nc1c(Cl)cc(OC(F)(F)F)cc1Cl)C1CCCCC1,,c1ccncc1,,CCCCCC,CCOC(C)=O,val
US06057350,COC1(c2ccccc2)CCC(NCCN)C(=C=O)C1.O=C1OCC(c2ccc(F)c(F)c2)N1C(=O)Oc1ccc([N+](=O)[O-])cc1>>COC(=O)C1(c2ccccc2)CCC(NCCNC(=O)N2C(=O)OCC2c2ccc(F)c(F)c2)CC1,,ClCCl,,,,val
US20150336986A1,Cn1c(=O)c2c(-c3cccc(F)c3)n3c(c2n(C)c1=O)C(c1nc(Cl)cs1)=CC(CO)C3>>Cn1c(=O)c2c(-c3cccc(F)c3)n3c(c2n(C)c1=O)C(c1nc(Cl)cs1)CC(CO)C3,[Pt],C1CCOC1,CCO,,,val
US20130096121A1,CC(C)(C)OC(=O)c1nc(N2CCc3cccc(C(=O)Nc4nc5cc(F)c(F)cc5s4)c3C2)ccc1-c1cnn(Cc2ccccc2)c1>>O=C(Nc1nc2cc(F)c(F)cc2s1)c1cccc2c1CN(c1ccc(-c3cnn(Cc4ccccc4)c3)c(C(=O)O)n1)CC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US06355642B1,CN1C(=O)C2(CCCCBr)CCCc3cccc1c32.OC1(c2ccccc2)CCNCC1>>CN1C(=O)C2(CCCCN3CCC(O)(c4ccccc4)CC3)CCCc3cccc1c32,,CCO,,O=C([O-])O.[Na+],,val
US04476311,COc1cccc(C=O)c1.Nc1ccccc1>>COc1cccc(C=Nc2ccccc2)c1,,CCOCC,,,,val
US20060211734A1,CC(=O)Cl.CN1CCC(Oc2cccc(N)n2)CC1>>CC(=O)Nc1cccc(OC2CCN(C)CC2)n1,,C1CCOC1,,CCN(CC)CC,,val
US20100016282A1,C[C@@H]1NCCN(CCCCN2CCC3(CC3)[C@H](O)C2)C1=O.O=C(Nc1cccc(-c2ccccc2)c1)Oc1ccccc1>>C[C@H]1C(=O)N(CCCCN2CCC3(CC3)[C@H](O)C2)CCN1C(=O)Nc1cccc(-c2ccccc2)c1,,CC#N,,,,val
US20110288090A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4ccnc(Cl)c4cc3-c3ccccc3)cc2)CCC1.C[Mg]Br>>Cc1nccc2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc12,,C1CCOC1,,,,val
US20060100244A1,COCOCc1ccc(CO)cn1.FS(F)(F)N1CCOCC1>>COCOCc1ccc(CF)cn1,,ClCCl,ClCCl,O=C([O-])O.[Na+],,val
US20130196974A1,[N-]=[N+]=NCC(=O)Nc1cc(N2CCCc3ccccc3C2)nc2ccccc12>>NCC(=O)Nc1cc(N2CCCc3ccccc3C2)nc2ccccc12,[Pd],CO,,,,val
US20050267177A1,COC(=O)c1c(C)cccc1CO[C@H]1CCC[C@@H](OCc2coc(-c3ccc(F)cc3)n2)C1.OCC1(CO)COCOC1>>OCC1(COCc2coc(-c3ccc(F)cc3)n2)COCOC1,,CN(C)C=O,,[H-].[Na+],,val
US20070179175A1,CC(C)N1CCC(O)CC1.Clc1ccc2c(n1)CCN(Cc1ccccc1)C2>>CC(C)N1CCC(Oc2ccc3c(n2)CCN(Cc2ccccc2)C3)CC1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US06762180B1,C1CCNCC1.O=[N+]([O-])c1ccc(CBr)cc1>>O=[N+]([O-])c1ccc(CN2CCCCC2)cc1,,ClCCl,,CCN(CC)CC,,val
US20070054902A1,CN(C)C=O.COCOCc1cc(-c2ccc(C(F)(F)F)cc2)on1>>COCOCc1noc(-c2ccc(C(F)(F)F)cc2)c1C=O,,CN(C)C=O,,C1CCOC1,[Li]CCCC,val
US20160214963A1,C=CC(=O)NCc1cccc([N+](=O)[O-])c1>>C=CC(=O)NCc1cccc(N)c1,,CCO,,Cl[Sn]Cl,,val
US20080261918A1,CC(C)(C)OC(=O)NCCOCc1ccccc1.Cc1ccc(S(=O)(=O)O)cc1>>Cc1ccc(S(=O)(=O)O)cc1.NCCOCc1ccccc1,,CC#N,,,,val
US20070260026A1,CC(C)(C)c1cc(Br)c(O)c(C(C)(C)C)c1.O=C1c2ccccc2-c2ccccc21>>CC(C)(C)c1cc(O)c(C2c3ccccc3-c3cccc(O)c32)c(C(C)(C)C)c1,,C1CCOC1,CCOCC,O,[Li]CCCC,val
US20140275087A1,CCCCNC(=O)O[C@@H]1CNC[C@H]1c1ccc(F)cc1.Cn1cnc(S(=O)(=O)Cl)c1>>CCCCNC(=O)O[C@@H]1CN(S(=O)(=O)c2cn(C)cn2)C[C@H]1c1ccc(F)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20060115425A1,COC(=O)C(C)(C)Oc1ccc(C#N)cn1>>CC(C)(Oc1ccc(C#N)cn1)C(=O)O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20150266837A1,CC=O.NNC(=O)OCc1ccccc1>>C/C=N/NC(=O)OCc1ccccc1,,ClC(Cl)Cl,,O=S(=O)([O-])[O-].[Mg+2],,val
US20100305131A1,CCOC(=O)C[C@@H](Cc1ccc(Br)cc1)NC(=O)CCC(=O)O.OB(O)c1ccc(F)cc1>>CCOC(=O)C[C@@H](Cc1ccc(-c2ccc(F)cc2)cc1)NC(=O)CCC(=O)O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20090275611A1,C=O.O[C@H](CNCc1ccc(Br)cc1)c1ccccc1>>CN(Cc1ccc(Br)cc1)C[C@@H](O)c1ccccc1,,C1CCOC1,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140088111A1,Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1>>C[C@H](N)[C@@H]1CC[C@H](c2ccc(C(F)(F)F)cc2)O1,,C1CCOC1,,,,val
US05536718,Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Cl)cn1.c1ccc2c(c1)NCc1cccn1-2>>Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3-c3ccccc32)cn1,,ClCCl,O,CCN(CC)CC,,val
US08367684B2,Cc1nc(N2CCc3ccccc3C2)nc(C)c1N(C(=O)CC(C)(C)C)C(=O)CC(C)(C)C>>Cc1nc(N2CCc3ccccc3C2)nc(C)c1NC(=O)CC(C)(C)C,,CO,,[NH4+].[OH-],,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccc(OC)cc4)nc(Cl)c3n2)cc1.Nc1ccc2c(c1)NC(=O)CC2>>COc1ccc(-c2nc(Nc3ccc4c(c3)NC(=O)CC4)c3[nH]ncc3n2)cc1,C1COCCO1,CO,,Cl,,val
US20120088764A1,COC(=O)/C=C/c1cccc([N+](=O)[O-])c1>>COC(=O)/C=C/c1cccc(N)c1,[Fe],CCO,,Cl,,val
US20100056498A1,C[Si](C)(C)CCOCN1C(=O)C2(Cc3cc([N+](=O)[O-])cnc3C2)c2cccnc21>>C[Si](C)(C)CCOCN1CC2(Cc3cc(N)c(=O)[nH]c3C2)c2cccnc21,[Pd],,,CO,,val
US20090286779A1,COc1ccc(-c2cnn3ccc(Cl)nc23)cc1OC.N[C@H]1CCCC[C@H]1O>>COc1ccc(-c2cnn3ccc(N[C@@H]4CCCC[C@@H]4O)nc23)cc1OC,,CN1CCCC1=O,,Cl,O,val
US04963530,N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1.O=C=Nc1ccc(C(F)(F)F)cc1>>O=C(Nc1ccc(C(F)(F)F)cc1)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1,,C1CCOC1,,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US20090263322A1,ClCCCCBr.Oc1ccc(C2CCCC3CCCN32)cc1>>ClCCCCOc1ccc(C2CCCC3CCCN32)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20020165241A1,Cc1ccc(COC(=O)N2CCC(CN)CC2)cc1.Fc1cnc(Cl)nc1>>Cc1ccc(COC(=O)N2CCC(CNc3ncc(F)cn3)CC2)cc1,,CN(C)C=O,,CCN(CC)CC,,val
US06482827B1,COc1ccc(CCCO)cc1.CS(=O)(=O)Cl>>COc1ccc(CCCOS(C)(=O)=O)cc1,,ClCCl,,CCN(CC)CC,,val
US20110070317A1,CC(=O)OC(C)=O.Nc1c[nH]c2ncc(Br)c(F)c12>>CC(=O)Nc1c[nH]c2ncc(Br)c(F)c12,,C1CCOC1,,,,val
US20060106041A1,O=S(=O)(c1ccccc1)n1cc(I)c2ccccc21.OB(O)c1cccs1.c1ccc(Cn2c(-c3ccoc3)cc3ccccc32)cc1>>O=S(=O)(c1ccccc1)n1c(-c2ccsc2)cc2ccccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20150328228A1,O=S(=O)(c1ccccc1)n1cc(-c2cnn(CC3CCNCC3)c2)c2cc(F)c(F)cc21.OCCBr>>O=S(=O)(c1ccccc1)n1cc(-c2cnn(CCO)c2)c2ccc(F)cc21,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130281452A1,C1COCCN1.CCS(=O)(=O)c1cc(Cl)cc(C)c1C#N>>CCS(=O)(=O)c1cc(N2CCOCC2)cc(C)c1C#N,,CN1CCCC1=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040082575A1,NOCc1ccccc1.O=C(O)/C=C/c1ccc(CC2c3ccc(OCc4ccccc4)cc3CCN2c2ccc(F)cc2)cc1>>O=C(/C=C/c1ccc(CC2c3ccc(OCc4ccccc4)cc3CCN2c2ccc(F)cc2)cc1)NOCc1ccccc1,CN(C)c1ccncc1,,,Cl,,val
US20110212918A1,COc1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(C)c1>>Cc1cc(O)ccc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2,,ClCCl,,BrB(Br)Br,O,val
US20090105214A1,CC(C)(C)OC(=O)n1ccc(N)n1.CN1CCOc2c(ccc(Oc3cc(O[C@H]4CCOC4)cc(C(=O)O)c3)c2Cl)C1=O>>CN1CCOc2c(ccc(Oc3cc(O[C@H]4CCOC4)cc(C(=O)Nc4ccn(C(=O)OC(C)(C)C)n4)c3)c2Cl)C1=O,,ClCCl,,c1ccncc1,,val
US20150119390A1,COC(=O)c1ccnc(-c2ccnc(F)c2)n1>>OCc1ccnc(-c2ccnc(F)c2)n1,,C1CCOC1,,CO,[BH4-].[Na+],val
US20120202867A1,CON=C(C)[C@@H]1C[C@H]1c1ccc(Cl)s1>>CONC(C)[C@@H]1C[C@H]1c1ccc(Cl)s1,,CC(=O)O,,[BH3-]C#N.[Na+],,val
US20080207654A1,CCCCc1nc(C)cc(=O)[nH]1.N#Cc1ccccc1-c1ccc(CBr)c(F)c1>>CCCCc1nc(C)cc(=O)n1Cc1ccc(-c2ccccc2C#N)cc1F,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110009432A1,Cc1ccc(N2CCc3ncnc(Cl)c3C2)nc1.Cc1ccc([C@H](N)CCO)cn1>>Cc1ccc(N2CCc3ncnc(N[C@H](CCO)c4ccc(C)nc4)c3C2)nc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20020156081A1,COc1cc(-c2nn([C@@H]3CC[C@@H](N4CCN(C)CC4)CC3)c3ncnc(N)c23)c(F)cc1N.O=C(Cl)[C@@H]1C[C@H]1c1ccccc1>>COc1cc(-c2nn(C3CCC(N4CCN(C)CC4)CC3)c3ncnc(N)c23)c(F)cc1NC(=O)[C@@H]1C[C@H]1c1ccccc1,,ClCCl,c1ccncc1,,,val
US20020019387A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.[O-][n+]1ccccc1NCCCO>>CC(C)(C)OC(=O)N(CCCO)c1cccc[n+]1[O-],,CC(C)(C)O,,,,val
US05576322,CSc1ccc2ncnc(Cl)c2c1.NCc1ccc2c(c1)OCO2>>CSc1ccc2ncnc(NCc3ccc4c(c3)OCO4)c2c1,,CC(C)O,,O=C([O-])[O-].[Na+].[Na+],,val
US06514968B1,N#CCOc1cccc2c1c1cccc(F)c1n2Cc1ccccc1>>NCCOc1cccc2c1c1cccc(F)c1n2Cc1ccccc1,,C1CCOC1,,B,CSC,val
US05714479,CCOC(=O)c1cncnc1C(=O)c1ccc(OC)cc1>>COc1ccc(C(=O)c2ncncc2C(=O)O)cc1,,O,,CO,[Na+].[OH-],val
US05925792,CCCCCCCCCCCCCCCC(=O)Cl.COC(=O)CC(C)=O>>CCCCCCCCCCCCCCCC(=O)CC(=O)OC,,C1CCOC1,,[H-].[Na+],,val
US20060183909A1,COC(=O)c1cc(O)c2cccc(OCc3ccccc3)c2n1>>O=C(O)c1cc(O)c2cccc(OCc3ccccc3)c2n1,,C1CCOC1,O,[Li+].[OH-],,val
US20040157890A1,CCCC[Sn](CCCC)(CCCC)c1cc(C)c(C2OCCO2)s1>>CCCC[Sn](CCCC)(CCCC)c1cc(C)c(C=O)s1,,C1CCOC1,,Cl,,val
US04436921,CCCCCCN1CCNC(=O)C1=O.O=[N+]([O-])c1ccc(CBr)cc1>>CCCCCCN1CCN(Cc2ccc([N+](=O)[O-])cc2)C(=O)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20100035863A1,CN1CCN(c2cc(NC3CCNCC3)nc(N)n2)CC1.COc1cccc(C(=O)Cl)c1>>COc1cccc(C(=O)N2CCC(Nc3cc(N4CCN(C)CC4)nc(N)n3)CC2)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04859229,C#CC(=O)O.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(O)c(Cl)cc2F)c1=O>>C#CC(=O)Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060276433A1,NNc1ccc(-c2cnco2)cc1.O=Cc1ccc(C(=O)O)cc1>>O=C(O)c1ccc(C=NNc2ccc(-c3cnco3)cc2)cc1,,CCO,,,,val
US20120208788A1,COc1cc(Br)c(OCc2ccccc2)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)c4onc(OCc5ccccc5)c4C(=O)[C@@]3(O[Si](C)(C)C(C)(C)C)C(O)=C1C2=O.O=O>>COc1cc(O)c(OCc2ccccc2)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)c4onc(OCc5ccccc5)c4C(=O)[C@@]3(O[Si](C)(C)C(C)(C)C)C(O)=C1C2=O,,C1CCOC1,,,,val
US20120214803A1,COc1ccc(CN)cc1.Clc1ccnc2cccnc12>>COc1ccc(CNc2ccnc3cccnc23)cc1,,CCCCO,,,,val
US20050131015A1,COCCN1C(=O)C(NC(=O)c2cc3cc(Cl)sc3[nH]2)Cc2ccccc21.Cl.ClCCl>>Cl.Cl.NC1Cc2ncccc2NC1=O,,C1COCCO1,ClCCl,,,val
US20120196869A1,CN1CCn2cccc2C12CCN(C(=O)OC(C)(C)C)CC2.FC(F)(F)I>>CN1CCn2c(C(F)(F)F)ccc2C12CCN(C(=O)OC(C)(C)C)CC2,,CS(C)=O,,OO,,val
US20140107194A1,CCOC(=O)c1ccc(C[C@@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@H]2O)cc1.Nc1ccc(O)c(C(=O)O)c1>>O=C(Nc1ccc(O)c(C(=O)O)c1)c1ccc(C[C@@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@H]2O)cc1,,C1CCOC1,,C[Al](C)C,,val
US04101667,COc1ccc2c(c1)CCc1c(C#N)cccc1S2.OCCOCCO.[OH-]>>O=C(O)c1cccc2c1CCc1cc(O)ccc1S2,,OCCOCCO,,O,,val
US20160175284A1,CC1=C(Br)C(O)Oc2ccc(OC3CCCCO3)cc21.FCC1CN(CCOc2ccc(Br)cc2)C1>>CC(=C(Br)C(O)c1ccc(OCCN2CC(CF)C2)cc1)c1cc(OC2CCCCO2)ccc1O,,C1CCOC1,,[Li]CCCC,,val
US04859700,CCOC(=O)CBr.O=C1Oc2ccc(Cl)cc2C1c1ccccc1>>CCOC(=O)CC1(c2ccccc2)C(=O)Oc2ccc(Cl)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20150322090A1,CCOC(=O)C1CC1C=O.CC[Mg]Br>>CCOC(=O)C1CC1C(O)CC,,C1CCOC1,,,,val
US20160176868A1,CC(C)N1C(=O)CC(=O)NC1=O.O=C(CBr)c1ccccc1>>CC(C)N1C(=O)NC(=O)C(CC(=O)c2ccccc2)C1=O,,C1CCOC1,O,[H-].[Na+],,val
US06162937,CC(=O)OCC1c2ccccc2-c2ccccc21>>C=C1c2ccccc2-c2ccccc21,,CCOCC,,Cl,CC(C)(C)[O-].[K+],val
US20040019063A1,N#Cc1ncc([N+](=O)[O-])cc1Cl>>N#Cc1ncc(N)cc1Cl,[Fe],CCO,,[Ca+2].[Cl-].[Cl-],,val
US20030207939A1,CC(=O)Nc1ccc(C(C)C)cc1.CCCCBr>>CCCCNc1ccc(C(C)C)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20150291563A1,COC(=O)C(=O)C=Cc1ccccc1Cl.NNc1cccc(Br)c1>>COC(=O)C1=NN(c2cccc(Br)c2)C(c2ccccc2Cl)C1,,CC(=O)O,,Cl,,val
US05530107,Br.CC(=O)OC[C@H]1O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1O[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@H](Br)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1O[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O,,CC(=O)O,,,,val
US20030149003A1,CC(C)(C)[Si](C)(C)Cl.COc1ccc(C=O)c(O)c1Br>>COc1ccc(C=O)c([Si](C)(C)C(C)(C)C)c1Br,,CN(C)C=O,,,,val
US20150225397A1,COc1cccc(C23CCC(=O)C(C)=C2CCCC3O)c1>>COc1cccc(C23CCC(=O)C(C)C2CCCC3O)c1,[Pd],CCOC(C)=O,,,,val
US20130116243A1,CSc1[nH]nc2c1CCc1nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc1-2>>CSc1[nH]nc2c1CCc1nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)cc1-2,,O=C(O)C(F)(F)F,,,,val
US05331006,COC(=O)c1nn(S(=O)(=O)c2ccc(C)cc2)c2ccccc12>>Cc1ccc(S(=O)(=O)n2nc(CO)c3ccccc32)cc1,,C1CCOC1,Cc1ccccc1,[Na+].[OH-],,val
US20140243336A1,Cc1cc(C)nc(Nc2cc(N)cnc2C#N)c1.O=C(Cl)CNC(=O)OCC1c2ccccc2-c2ccccc21>>Cc1cc(C)nc(Nc2cc(NC(=O)CNC(=O)OCC3c4ccccc4-c4ccccc43)cnc2C#N)c1,,CCOC(C)=O,CN(C)C=O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US05410054,CCOC(=O)CC(=O)c1ccccc1.COc1cccc(N)c1>>COc1cccc(NC(=O)CC(=O)c2ccccc2)c1,c1ccncc1,Cc1ccccc1C,,,,val
US20090030041A1,CC(=O)OC(C)=O.COC(=O)C1(N(C(=O)c2ccco2)c2cccc(N)c2)CCN(CC(C(=O)OCc2ccccc2)c2ccccc2)CC1>>COC(=O)C1(N(C(=O)c2ccco2)c2cccc(NC(C)=O)c2)CCN(CC(C(=O)OCc2ccccc2)c2ccccc2)CC1,,Cc1ccccc1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20120115861A1,NCCc1ccc(N)c([N+](=O)[O-])c1.O=C(Cl)c1ccc(F)c(F)c1>>Nc1ccc(CCNC(=O)c2ccc(F)c(F)c2)cc1[N+](=O)[O-],,C1COCCO1,,CCN(CC)CC,CCOC(C)=O,val
US20070275987A1,CCc1cnc(Cl)c(C(=O)NC(=N)COCCc2cc(F)ccc2F)c1>>CCc1cnc2nc(COCCc3cc(F)ccc3F)[nH]c(=O)c2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080255113A1,CC(C)n1c(=O)c(C(=O)O)cc2c(Cl)cccc21.NCC1CCN(CC2(O)CCOCC2)CC1>>CC(C)n1c(=O)c(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)cc2c(Cl)cccc21,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20060235031A1,NC(c1ccc2ccc(-c3ccccc3)nc2c1)c1nccnc1Cl.O=C(Cl)C1CCN(C(=O)OCc2ccccc2)CC1>>O=C(NC(c1ccc2ccc(-c3ccccc3)nc2c1)c1nccnc1Cl)C1CCN(C(=O)OCc2ccccc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20050009895A1,COc1cc(C(=O)NCc2ccc(-c3noc(C)n3)cc2N)cc(OC)c1C.O=C(Cl)Oc1ccccc1>>COc1cc(C(=O)NCc2ccc(-c3noc(C)n3)cc2NC(=O)Oc2ccccc2)cc(OC)c1C,,ClCCCl,,O=C([O-])[O-].[K+].[K+],,val
US20060074102A1,CCNC(=O)NNC(=O)c1cc2c(Nc3ccc(-c4ccccc4)cc3)cncc2s1>>CCn1c(-c2cc3c(Nc4ccc(-c5ccccc5)cc4)cncc3s2)n[nH]c1=O,,O,,O=C([O-])[O-].[K+].[K+],,val
US20130310384A1,CC(=O)OC(C)=O.O=S(=O)(N[C@@H](CO)c1ccccc1)c1ccc(Cl)cc1>>CC(=O)OC[C@H](NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1,,CCOC(C)=O,,,,val
US20140008570A1,COC(=O)CCc1cc(-c2ccc(O)cc2)cc(-c2ccc(O)cc2)c1>>OCCCc1cc(-c2ccc(O)cc2)cc(-c2ccc(O)cc2)c1,,C1CCOC1,Cc1ccccc1,CC(C)C[AlH]CC(C)C,,val
US20130005964A1,CNS(C)(=O)=O.Cc1ccnc(Cl)c1C#N>>Cc1ccnc(N(C)S(C)(=O)=O)c1C#N,,CC#N,,,,val
US20120309757A1,CS(N)(=O)=O.Cc1c(C)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)c2ccc(C(=O)N[C@@H](C)c3cccc(C(C)C)c3)cc12>>Cc1c(C)n(Cc2ccc(-c3ccccc3C(=O)NS(C)(=O)=O)cc2)c2ccc(C(=O)N[C@@H](C)c3cccc(C(C)C)c3)cc12,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,,val
US20070043090A1,CCCC1(C(O)CC=CCN(CCCCCCC(=O)OCC)S(C)(=O)=O)CCC1>>CCCC1(C(O)CC=CCN(CCCCCCC(=O)O)S(C)(=O)=O)CCC1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US05416236,CCS(=O)(=O)Nc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(F)cc1Cl.COS(=O)(=O)OC>>CCS(=O)(=O)Nc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160096827A1,CN1CCC(c2ccc(N)cc2)CC1.N#Cc1cc(-c2ncnc(Cl)n2)ccc1OC1CCOCC1>>CN1CCC(c2ccc(Nc3ncnc(-c4ccc(OC5CCOCC5)c(C#N)c4)n3)cc2)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20020128287A1,Cc1ccc(F)c(I)c1.O=C1CCC(=O)N1Br>>Fc1ccc(CBr)cc1I,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,,,val
US05180742,CCOC(=O)C(C)(C)CCCCC(c1ccccc1)c1c(C)c(OC)c(C)c(C)c1OC>>COc1c(C)c(C)c(OC)c(C(CCCCC(C)(C)C(=O)O)c2ccccc2)c1C,,CCO,,[Na+].[OH-],,val
US20090023707A1,COC(=O)c1nc(-c2ccc(Cn3cnc4ccccc43)cc2)oc1C>>Cc1oc(-c2ccc(Cn3cnc4ccccc43)cc2)nc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05123951,CCOC(=O)C1(C(=O)Cl)CCC1.Cc1cc(Br)ccc1N>>CCOC(=O)C1(C(=O)Nc2ccc(Br)cc2C)CCC1,,C1CCOC1,,CCN(CC)CC,,val
US03941796,COc1ccc(C(=O)c2cccc(C)n2)cc1OC.OCCCO>>COc1ccc(C2(c3cccc(C)n3)OCCCO2)cc1OC,,Cc1ccccc1,O,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20020035137A1,C1CCNCC1.COCCl.O=[N+]([O-])c1cc(O)ccc1Cl>>COCOc1ccc(N2CCCCC2)c([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090324581A1,CC(C)(C)OC(=O)CCN(CC(=O)N1CCc2cc(OCc3cnn(-c4ccccc4)c3C(F)(F)F)ccc21)C(=O)OC(C)(C)C>>O=C(O)CCNCC(=O)N1CCc2cc(OCc3cnn(-c4ccccc4)c3C(F)(F)F)ccc21,,ClCCl,O=C(O)C(F)(F)F,,,val
US20110245429A1,COc1ccc2cc(-c3ccc(-n4c5ccccc5c5ccccc54)cc3)ccc2c1>>Oc1ccc2cc(-c3ccc(-n4c5ccccc5c5ccccc54)cc3)ccc2c1,,ClCCl,,BrB(Br)Br,,val
US04565425,CCC/C=C/[C@@H]1CC[C@@H](C(=O)O)CC1.CCOc1ccc(O)cc1>>CCC/C=C/[C@@H]1CC[C@@H](C(=O)Oc2ccc(OCC)cc2)CC1,CN(C)c1ccncc1,CCOCC,ClCCl,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20070167433A1,COCCCN1CCOc2ccc(CC[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)C[C@@H](OC[C@H]4CO4)[C@@H]3c3ccc(COCCOC)cc3)cc21>>COCCCN1CCOc2ccc(CC[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)C[C@@H](OC[C@@H](C)O)[C@@H]3c3ccc(COCCOC)cc3)cc21,,C1CCOC1,CCO,[BH4-].[Na+],[Cl-].[NH4+],val
US20110021520A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1=NC(c2cc(Br)ccc2F)(C(F)F)COC1>>CC(C)(C)OC(=O)NC1=NC(c2cc(Br)ccc2F)(C(F)F)COC1,,C1CCOC1,COC(C)(C)C,CCN(C(C)C)C(C)C,,val
US20160090357A1,C=CC(OCC)OCC.Cc1ccc(NC(=O)CC(=O)c2ccc([N+](=O)[O-])cc2)cc1C(F)(F)F.N[C@@H](CO)c1ccccc1>>Cc1ccc(NC(=O)C2=C(c3ccc([N+](=O)[O-])cc3)N3C(CC2)OC[C@H]3c2ccccc2)cc1C(F)(F)F,,C1COCCO1,ClCCl,O=CO,,val
US20140081017A1,CC#N.COP(=O)(CC(C)=O)OC.Cc1ccc(S(=O)(=O)N=[N+]=[N-])cc1>>C#CCCC1CCCCC1,,CC#N,CO,O=C([O-])[O-].[K+].[K+],,val
US04704459,CCOC(=O)C(=CN(C)C)C(=O)c1cc(F)c(N2CCC(NC(C)=O)C2)nc1Nc1ccc(F)cc1F.Cl>>Cl.NC1CCN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccc(F)cc2F)C1,,CCO,,,,val
US20110009444A1,CC(Br)C(=O)c1ccccc1.Nc1cc(NC(=O)c2cc3cc(F)ccc3n2Cc2cccc(F)c2)ccn1>>Cc1nc2cc(NC(=O)c3cc4cc(F)ccc4n3Cc3cccc(F)c3)ccn2c1-c1ccccc1,,CC#N,,,,val
US20100063080A1,Fc1cccc(CBr)c1F.NC(N)=S>>Br.N=C(N)SCc1cccc(F)c1F,,CCO,,,,val
US04440929,CCOC(=O)c1nc[nH]c1C(=O)OCC.O=[N+]([O-])c1ccccc1F>>CCOC(=O)c1ncn(-c2ccccc2[N+](=O)[O-])c1C(=O)OCC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070043064A1,CCN(c1cccc(C(=O)C=CN(C)C)c1)S(C)(=O)=O.Nc1[nH]ncc1[N+](=O)[O-]>>CCN(c1cccc(-c2ccnc3c([N+](=O)[O-])cnn23)c1)S(C)(=O)=O,,CC(=O)O,,CCOC(C)=O,,val
US20100261755A1,COC(=O)c1ccnc(Cc2ccc(C(F)(F)F)c(F)c2)c1>>COC(=O)C1CCNC(Cc2ccc(C(F)(F)F)c(F)c2)C1,O=[Pt]=O,CC(=O)O,,,,val
US20090163586A1,NS(=O)(=O)c1cc(C(=O)O)ccc1NS(=O)(=O)CCc1ccc(Br)cc1>>NS(=O)(=O)c1cc(CO)ccc1NS(=O)(=O)CCc1ccc(Br)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100016279A1,O=C([O-])N1CCN(C(=O)c2ccc3[nH]cc(C4CCN(c5ccc6nnc(C(F)(F)F)n6n5)CC4)c3c2)CC1>>O=C(c1ccc2[nH]cc(C3CCN(c4ccc5nnc(C(F)(F)F)n5n4)CC3)c2c1)N1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060100262A1,COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCN(C(=O)Cn1ccnc1)Cc1cc(F)ccc1-3>>O=C(O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCN(C(=O)Cn1ccnc1)Cc1cc(F)ccc1-3,,C1COCCO1,O,[K+].[OH-],,val
US20100298287A1,CC(C)[Mg]Cl.O=Cc1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl>>CC(C)C(O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl,,C1CCOC1,,,,val
US05208345,COC(=O)[C@H](C)O.O=S(=O)(Cl)c1ccccc1>>COC(=O)[C@H](C)OS(=O)(=O)c1ccccc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20090227590A1,CN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1.O=C(CBr)Nc1ncncn1>>C[N+]1(CC(=O)Nc2ncncn2)CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1.[Br-],,CC#N,ClC(Cl)Cl,,,val
US20050288273A1,CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCCC3=O)C(=O)O1.O=C(Cl)c1nc2ccccc2s1>>CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCC(C(=O)c2nc4ccccc4s2)C3=O)C(=O)O1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20050143427A1,C=O.COC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1>>COC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C,,CC#N,,CC(=O)[O-].[Na+],,val
US04595780,CN(C)S(=O)(=O)Nc1ccc(C(=O)Nc2ccc(Cl)cc2)cc1.COS(=O)(=O)OC>>CN(C)S(=O)(=O)N(C)c1ccc(C(=O)Nc2ccc(Cl)cc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080262230A1,NCC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1.O=C(Cl)c1ccc(F)cc1>>O=C(NCC(COCc1ccc(C(F)(F)F)c(C(F)(F)F)c1)c1ccccc1)c1ccc(F)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20030013718A1,CC(C)(C)C1CCC(N)CC1.Clc1nnc(Cc2ccncc2)c2ccccc12>>CC(C)(C)[C@@H]1CC[C@H](Nc2nnc(Cc3ccncc3)c3ccccc23)CC1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20070105908A1,COC(=O)c1ccccc1S(=O)(=O)/N=c1\sc(CNC(=O)OC(C)(C)C)cn1Cc1cccc2ccccc12>>COC(=O)c1ccccc1S(=O)(=O)/N=c1\sc(CN)cn1Cc1cccc2ccccc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100004459A1,CC(C)(C)COc1ccc(Br)cc1C(F)(F)F.CC(C)OB(OC(C)C)OC(C)C>>CC(C)(C)COc1ccc(B(O)O)cc1C(F)(F)F,,C1CCOC1,O,Cl,[Li]CCCC,val
US20150274733A1,COC(=O)C1c2nc(S(C)(=O)=O)ncc2C(C)(C)N1C(=O)OCc1ccccc1>>CSc1ncc2c(n1)CN(C(=O)OCc1ccccc1)C2(C)C,,C1COCCO1,,[Na+].[OH-],[Cl-].[NH4+],val
US20120088748A1,CC(=O)Cl.CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Cl)c(Cl)c2)[C@H](CN)C1>>CC(=O)NC[C@@H]1CN(C(=O)OC(C)(C)C)CCO[C@H]1c1ccc(Cl)c(Cl)c1,,C1CCOC1,,CCN(CC)CC,,val
US20020086891A1,Cc1sc2cc(OCCOS(C)(=O)=O)ccc2c1-c1ccc(C(F)(F)F)cc1.c1c[nH]cn1>>Cc1sc2cc(OCCn3ccnc3)ccc2c1-c1ccc(C(F)(F)F)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20090036440A1,COc1ccc(C)c(N)c1.Clc1ccnc(Cl)n1>>COc1ccc(C)c(Nc2ccnc(Cl)n2)c1,,CCO,,CCN(CC)CC,,val
US20060264631A1,CCI.Cc1[nH]cnc1C=O>>CCn1cnc(C=O)c1C,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20100197697A1,CCOC(=O)C1CCN(C(=O)OC(C)(C)C)CC1c1ccc(F)c(F)c1>>COC(=O)C1CCN(C(=O)OC(C)(C)C)CC1c1ccc(F)c(F)c1,,CO,,C[O-].[Na+],,val
US05843983,CCOC(=O)N1C[C@H](O)C[C@H]1CCOc1ccc(F)cc1CCc1ccc(F)c(OC)c1>>COc1cc(CCc2cc(F)ccc2OCC[C@@H]2C[C@@H](O)CN2C)ccc1F,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070060573A1,CCC(=O)c1ccc(OC)c(OC)c1.COc1ccc2c(c1)C(=O)C(=O)N2>>COc1ccc2nc(-c3ccc(OC)c(OC)c3)c(C)c(C(=O)O)c2c1,,O,,[K+].[OH-],,val
US20100298343A1,CCOC(=O)C(Cc1ccccc1)c1[nH]c2ccc(O)cc2c1SC(C)(C)C.ClCc1ccccn1>>CCOC(=O)C(Cc1ccccc1)c1[nH]c2ccc(OCc3ccccn3)cc2c1SC(C)(C)C,,CC#N,O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20150291563A1,CS(=O)(=O)Cl.Fc1ccc(N2N=C(C(F)(F)C(F)(F)F)CC2c2cc(C3=CCNCC3)ccn2)c(F)c1>>CS(=O)(=O)N1CC=C(c2ccnc(C3CC(C(F)(F)C(F)(F)F)=NN3c3ccc(F)cc3F)c2)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US20070009597A1,CN1CC=C(c2cn(S(=O)(=O)C3CCCCC3)c3ccc([N+](=O)[O-])cc23)CC1>>CN1CC=C(c2cn(S(=O)(=O)C3CCCCC3)c3ccc(N)cc23)CC1,[Pd],CCO,,,,val
US20120184542A1,COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CNC(=O)OC(C)(C)C)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1>>COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05861401,COc1nc(C)cnc1N(C(=O)OCC(C)C)S(=O)(=O)c1ccccc1-c1ccc(C)cc1>>COc1nc(C)cnc1NS(=O)(=O)c1ccccc1-c1ccc(C)cc1,,CO,COCCOC,[Na+].[OH-],,val
US20160221998A1,CC1=C(I)C(=O)OC(C)(C)O1.OB(O)c1cccnc1F>>CC1=C(c2cccnc2F)C(=O)OC(C)(C)O1,,O,,C1CCOC1,O=C([O-])[O-].[Na+].[Na+],val
US20090054483A1,CCC(O)(CC)c1nnc(N)s1.N#Cc1cc(-c2ccccc2)c2ccc(C=O)cc2n1>>CCC(O)(CC)c1nnc(NCc2ccc3c(-c4ccccc4)cc(C#N)nc3c2)s1,,C1CCOC1,Cc1ccccc1,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040167123A1,O=C(NS(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(c1c(O)c3ccccc3n(NC3CCC3)c1=O)N2)OCc1ccccc1>>NS(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(c1c(O)c3ccccc3n(NC3CCC3)c1=O)N2,[Pd],C1CCOC1,CO,,,val
US20020119973A1,Clc1ccc(C2CCN(CCC=C3Cc4cc(Br)ccc4Oc4ncccc43)CC2)cc1.O=C=O>>O=C(O)c1ccc2c(c1)CC(=CCCN1CCC(c3ccc(Cl)cc3)CC1)c1cccnc1O2,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20110218189A1,CC(C)(C)OC(=O)N1CCC[C@H](CNc2nc(Cl)ncc2C#Cc2ccccc2Cl)C1>>CC(C)(C)OC(=O)N1CCC[C@H](Cn2c(-c3ccccc3Cl)cc3cnc(Cl)nc32)C1,,CCOC(C)=O,CN1CCCC1=O,CC(C)(C)[O-].[K+],,val
US20080292588A1,CC[C@H](N)CC(=O)OC.O=Cc1ccc(F)cc1>>CC[C@@H](CC(=O)OC)NCc1ccc(F)cc1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US05547949,C1CC2(CCN1)OCCO2.Clc1cc(Cl)nc(N2CCC3(CC2)OCCO3)n1>>Clc1cc(N2CCC3(CC2)OCCO3)nc(N2CCC3(CC2)OCCO3)n1,,CCCCO,,,,val
US20140243310A1,BrCC1CC1.COC(=O)c1ccc(O)c(Cl)c1>>O=C(O)c1ccc(OCC2CC2)c(Cl)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20150141650A1,COC12CC3CC(C1)N(C(=O)OC(C)(C)C)C(C3)C2>>COC12CC3CC(C1)NC(C3)C2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130225552A1,Clc1nc2ccccc2s1.N[C@H]1C[C@H](n2ccc3cccnc32)C1>>c1cnc2c(c1)ccn2[C@@H]1C[C@@H](Nc2nc3ccccc3s2)C1,CN(C)c1ccncc1,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20080292548A1,CNC.COC(=O)c1ccc(F)cc1C(F)(F)F>>COC(=O)c1ccc(N(C)C)cc1C(F)(F)F,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20050090498A1,CCCI.Cc1cc(Br)c([N+](=O)[O-])cc1C(=O)O>>CCCOC(=O)c1cc([N+](=O)[O-])c(Br)cc1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050107377A1,Fc1ccc2c(-c3ccc(OC[C@H]4CO4)cc3)noc2c1.NCc1ccc(F)c(F)c1>>O[C@H](CNCc1ccc(F)c(F)c1)COc1ccc(-c2noc3cc(F)ccc23)cc1,,CCO,,,,val
US20090069562A1,CNCCC#N.COc1cc2nc(Cl)nc(N)c2cc1OC>>COc1cc2nc(CNCCC#N)nc(N)c2cc1OC,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060004069A1,COC(=O)C(O)Cc1ccc(NC(=O)/C=C/c2cnn(C)c2-c2ccc(F)cc2)cc1>>Cn1ncc(/C=C/C(=O)Nc2ccc(CC(O)C(=O)O)cc2)c1-c1ccc(F)cc1,,CO,,Cl,[Na+].[OH-],val
US20080153828A1,CI.Fc1ccc2[nH]ccc2c1>>Cn1ccc2cc(F)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20110046169A1,COC(=O)c1cccc(-c2ccccc2)n1.O=C(OO)c1cccc(Cl)c1>>COC(=O)c1cccc(-c2ccccc2)[n+]1[O-],,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20030236282A1,CCOC(=O)C(N)Cc1cc(Cl)c(N)c(C(F)(F)F)c1.CN(C)C=O.O=C1Nc2ccccc2CCN1C1CCNCC1>>CCOC(=O)C(Cc1cc(Cl)c(N)c(C(F)(F)F)c1)NC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1,,O,,CCN(CC)CC,,val
US20030092720A1,COc1ccc(Cn2nnnc2-c2c(N3CCOCC3)nc3cc(CCc4nc(C(C)C)cs4)ccn3c2=O)cc1>>CC(C)c1csc(CCc2ccn3c(=O)c(-c4nnn[nH]4)c(N4CCOCC4)nc3c2)n1,,O=C(O)C(F)(F)F,,COc1ccccc1,,val
US20040062798A1,O=C([O-])[O-].O=C([O-])[O-].O=S([O-])[O-].OO.OO.OO.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]>>O=C([O-])[O-].O=C([O-])[O-].O=S([O-])[O-].OO.OO.OO.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+],,O,,OO,,val
US04933355,O=C1CSC(=O)N1.O=Cc1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>O=C1NC(=O)C(=Cc2csc(NC(c3ccccc3)(c3ccccc3)c3ccccc3)n2)S1,,CCO,,C1CCNCC1,,val
US05525742,O=[N+]([O-])c1cc(I)cc([N+](=O)[O-])c1>>Nc1cc(N)cc(I)c1,,CCO,,[Na+].[OH-],,val
US20140057909A1,CC(C)(C)OC(=O)n1cc(/C=C/C(=O)O)c2ccccc21.CC(C)NNC(=O)c1ccc(O)cc1>>CC(C)N(NC(=O)c1ccc(O)cc1)C(=O)/C=C/c1cn(C(=O)OC(C)(C)C)c2ccccc12,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030105132A1,CCC(C#N)(CC)O[PH](=O)[O-].O=Cc1ccc(Cl)c(F)c1>>N#CC=Cc1ccc(Cl)c(F)c1,,C1CCOC1,,O,[H-].[Na+],val
US20040082619A1,CCCCn1cc(I)cc(C(=O)NCc2ccccc2)c1=O.OB(O)Oc1ccccc1>>CCCCn1cc(-c2ccccc2)cc(C(=O)NCc2ccccc2)c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CN(C)C=O,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20040058903A1,CC(C)(C)OC(=O)N(CCc1ccccn1)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1>>O=C(Nc1ccc(NCCc2ccccn2)cc1)c1ccccc1-c1ccc(C(F)(F)F)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120046267A1,Nc1nccc2cc(Cl)oc12.O=C1CCC(=O)N1I>>Nc1ncc(I)c2cc(Cl)oc12,,CC#N,,,,val
US20100113439A1,CC(C)NC(=O)c1nc[nH]n1.CN[C@@](C)(CO[C@H]1[C@H](OC(C)=O)C[C@@]23COC[C@]1(C)[C@@H]2CC[C@H]1C3=CC(=O)[C@@]2(C)[C@H](C(=O)O)[C@@](C)([C@H](C)C(C)C)CC[C@]12C)C(C)C>>CN[C@@](C)(CO[C@H]1[C@H](n2ncnc2C(=O)NC(C)C)C[C@@]23COC[C@]1(C)[C@@H]2CC[C@H]1C3=CC(=O)[C@@]2(C)[C@H](C(=O)O)[C@@](C)([C@H](C)C(C)C)CC[C@]12C)C(C)C,,ClCCCl,,,,val
US05849796,COC(=O)c1cc(S(C)(=O)=O)c(Cl)cc1C>>Cc1cc(Cl)c(S(C)(=O)=O)cc1C(=O)O,,CO,,Cl,,val
US20120245366A1,CC1(C)[C@@H]2CC[C@@]1(C)C=C2OS(=O)(=O)C(F)(F)F.CCCCCCC(C)(C)c1cc(OC)c(C2=C[C@@H]3CC[C@@]2(C(=O)OC)C3(C)C)c(OC)c1>>CCCCCCC(C)(C)c1cc(OC)c(C2=C[C@]3(C)CC[C@H]2C3(C)C)c(OC)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20100249187A1,CC(C)(C)C(=O)COC(=O)C1(C(=O)OCc2ccccc2)CCCN(C(=O)OCC(Cl)(Cl)Cl)C1>>CC(C)(C)C(=O)COC(=O)C1(C(=O)OCc2ccccc2)CCCNC1,[Zn],C1CCOC1,,C,O=C[O-].[NH4+],val
US20050187390A1,CCOC(=O)c1ccc2[nH]c(-c3ccccc3)cc(=O)c2c1>>O=C(O)c1ccc2[nH]c(-c3ccccc3)cc(=O)c2c1,,CCO,,[Na+].[OH-],,val
US20120309796A1,CC(C)(C)OC(=O)CBr.O=C1CCCCc2c(O)cccc21>>CC(C)(C)OC(=O)COc1cccc2c1CCCCC2=O,,CC#N,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US05296495,CCOC(=O)C(Cc1ccc2oc(-c3nc(C(C)(C)C)cs3)cc2c1)C(=O)OCC>>CC(C)(C)c1csc(-c2cc3cc(CC(C(=O)O)C(=O)O)ccc3o2)n1,,Cl,,,,val
US20130029953A1,C[C@]12C[C@H](c3ccc(C(O)C4CC4)cc3)C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@]2(O)C(F)(F)C(F)(F)F>>C[C@]12C[C@H](c3ccc(C(=O)C4CC4)cc3)C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@]2(O)C(F)(F)C(F)(F)F,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20120065195A1,CC1(CO)Cc2ccc(Br)cc2C2(COC(N)=N2)C1.OB(O)c1cncc(Cl)c1>>C[C@@]1(CO)Cc2ccc(-c3cncc(Cl)c3)cc2[C@]2(COC(N)=N2)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20110237584A1,C[Si](C)(C)C(F)(F)F.O=Cc1cncn1CC1CC1>>OC(c1cncn1CC1CC1)C(F)(F)F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080194633A1,CC(C)(CCO)C(=O)NCc1ccccc1Cl.CCc1ccc(N=C=O)cc1>>CCc1ccc(NC(=O)OCCC(C)(C)C(=O)NCc2ccccc2Cl)cc1,CN(C)c1ccncc1,C1CCOC1,,,,val
US04242515,CC(=O)NN.FC(F)(F)c1cccc(-c2ccc(Cl)nc2)c1>>Cc1nnc2ccc(-c3cccc(C(F)(F)F)c3)cn12,,CCCCO,,,,val
US20120070374A1,COc1ccc2nc(N)sc2c1.O=C(CBr)c1ccc([N+](=O)[O-])cc1>>COc1ccc2c(c1)sc1nc(-c3ccc(N)cc3)cn12,,CCO,,Cl[Sn]Cl,,val
US04341698,CC(C)(C)OC(=O)N1CCNC(=O)C1.c1ccc(SSc2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCNC(=O)C1Sc1ccccc1,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US20110213028A1,CC#N.CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O>>CCC=CCC=CCC=CCC=CCC=CCC=CCCC(N)=O,,CC#N,CCOC(C)=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04029638,NCCO.O=S1(=O)CCCO1>>O=S(=O)(O)CCCNCCO,,CO,,,,val
US07612075B2,CCOP(=O)(OCC)C(N(C)C)P(=O)(OCC)OCC.O=Cc1ccc(Cl)s1>>CCOP(=O)(OCC)C(=Cc1ccc(Cl)s1)N(C)C,,C1CCOC1,,[H-].[Na+],,val
US04380645,COC(=O)c1cc(COc2cccc(C)c2)c(C(=O)OC)n1C>>Cc1cccc(OCc2cc(C(=O)O)n(C)c2C(=O)O)c1,,CO,O,[Na+].[OH-],,val
US20030105087A1,Brc1cnc2[nH]ccc2c1.CO>>COc1cnc2[nH]ccc2c1,[Cu]Br,CN(C)C=O,CO,C[O-].[Na+],,val
US04728658,Nc1ccc(Cl)c(C(F)(F)F)c1.O=C(O)c1cc[n+]([O-])cc1>>O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)c1cc[n+]([O-])cc1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20110046169A1,Cc1cc(N)ccc1Oc1ccc2nc(NC(=O)C3CC3)cn2c1.Cc1ccc(C(=O)O)c(=O)n1-c1ccc(F)cc1>>Cc1cc(NC(=O)c2ccc(C)n(-c3ccc(F)cc3)c2=O)ccc1Oc1ccc2nc(NC(=O)C3CC3)cn2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160222014A1,COCCN(c1ccccc1Cn1ccc2cnc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cc3)nc21)S(C)(=O)=O>>COCCN(c1ccccc1Cn1ccc2cnc(Nc3ccc(N4CCNCC4)cc3)nc21)S(C)(=O)=O,,ClCCl,O,CO,O=C(O)C(F)(F)F,val
US20100204226A1,CCOC(=O)c1cnn(-c2nc3ccc(N)cc3c(=O)n2COCC[Si](C)(C)C)c1.O=S(=O)(Cl)c1ccccc1>>CCOC(=O)c1cnn(-c2nc3ccc(NS(=O)(=O)c4ccccc4)cc3c(=O)n2COCC[Si](C)(C)C)c1,,c1ccncc1,,,,val
US20030073731A1,COc1cc2cc(C(=O)Nc3cc(OCc4ccccc4)c4ccccc4c3CCOC(C)=O)[nH]c2c(OC)c1OC>>COc1cc2cc(C(=O)Nc3cc(OCc4ccccc4)c4ccccc4c3CCO)[nH]c2c(OC)c1OC,,CCOC(C)=O,CO,O=C([O-])[O-].[K+].[K+],,val
US20090192322A1,Cc1ccc(S(=O)(=O)O[C@H](CO)[C@@H]2C=CCO2)cc1.N>>NC[C@H](O)[C@@H]1C=CCO1,,[NH4+],[OH-],CC(C)O,,val
US20100204226A1,CCOC(=O)c1cnn(-c2nc3ccc([N+](=O)[O-])cc3c(=O)n2COCC[Si](C)(C)C)c1>>CCOC(=O)c1cnn(-c2nc3ccc(N)cc3c(=O)n2COCC[Si](C)(C)C)c1,[Zn],CC(C)=O,,O,[Cl-].[NH4+],val
US05413794,CCCCCCCCCCCC(=O)Cl.NCC(=O)O>>CCCCCCCCCCCC(=O)NCC(=O)O,,CCOCC,,Cl,[Na+].[OH-],val
US20140288066A1,CCSc1nc2c(c(=O)[nH]1)CSC2.O>>O=c1[nH]c2c(c(=O)[nH]1)CSC2,,O,,CC(=O)O,Cl,val
US20050171109A1,CCOC(=O)C(=O)CC1(c2cccc(F)c2OC)CC1.C[Si](C)(C)C(F)(F)F>>CCOC(=O)C(O)(CC1(c2cccc(F)c2OC)CC1)C(F)(F)F,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20090227603A1,CS(=O)(=O)c1cc(I)cc([N+](=O)[O-])c1.O/N=C\c1ccccc1>>CS(=O)(=O)c1cc(O)cc(I)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100273786A1,CC(C)(C)OC(=O)N[C@@H](CC(=O)N1CCn2c(C(F)(F)F)nc(C(=O)N3CCCC3)c2C1)Cc1cc(F)c(F)cc1F.Cl>>Cl.N[C@@H](CC(=O)N1CCn2c(C(F)(F)F)nc(C(=O)N3CCCC3)c2C1)Cc1cc(F)c(F)cc1F,,CCOC(C)=O,,,,val
US20100204257A1,COC(=O)C(C)(C)Br.O=Cc1cc(Cl)cnc1O>>COC(=O)C(C)(C)Oc1ncc(Cl)cc1C=O,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20090137624A1,C[C@H](Nc1nc(F)c(F)cc1[N+](=O)[O-])c1ccc(F)cc1.Cc1cc(N)n[nH]1>>Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)c([N+](=O)[O-])cc2F)n[nH]1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20100120763A1,COc1cc(C(F)(F)F)cc2c1nnc1c(C)ncn12.NC(=O)CCC(=O)NBr>>COc1cc(C(F)(F)F)cc2c1nnc1c(C)nc(Br)n12,,CC#N,,,,val
US20060278848A1,C=CCCCCCCCCBr.OCc1ccc(O)cc1>>C=CCCCCCCCCOC(O)c1ccccc1,,CCO,,[Na+].[OH-],,val
US20090233897A1,C[Si](C)(C)C#CCBr.c1cncc(Cc2cccnc2)c1>>C[Si](C)(C)C#CCC(c1cccnc1)c1cccnc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20140128372A1,CC(C)(C)OC(=O)N1CCC[C@H]1CN.Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)O)n2c1.O=C(O)C(F)(F)F>>Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NC[C@@H]3CCCN3C(=O)OC(C)(C)C)n2c1.O=C(O)C(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US05395849,CC(C)(C)[Si](C)(C)OC12C#CC=CC#CC(OC(=O)COc3ccccc3)C(=CCC1)C2=O>>O=C(COc1ccccc1)OC1C#CC=CC#CC2(O)CCC=C1C2=O,,CC#N,ClC(Cl)Cl,,,val
US20030229066A1,COC(=O)c1sc2cc(C(F)(F)F)ccc2c1C1CCN(C(=O)OC)CC1>>COC(=O)N1CCC(c2c(C(=O)O)sc3cc(C(F)(F)F)ccc23)CC1,,C1CCOC1,O,[Na+].[OH-],,val
US07160887B1,C[C@H](NC(=O)OC(C)(C)C)c1cccc(O)c1.O=[N+]([O-])c1ccc(Cl)cc1F>>C[C@H](NC(=O)OC(C)(C)C)c1cccc(Oc2cc(Cl)ccc2[N+](=O)[O-])c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090163472A1,CC(C)(C)OC(=O)N1CC[C@@H](N)[C@H](O)C1.O=[N+]([O-])c1cc(Br)ccc1F>>CC(C)(C)OC(=O)N1CC[C@@H](Nc2ccc(Br)cc2[N+](=O)[O-])[C@H](O)C1,,CCOC(C)=O,,CCN(CC)CC,,val
US20070197526A1,CC(C)(C)OC(=O)N1CCC(O)CC1.Cc1cc(C(=O)NC2CCCCC2)n(-c2ccc(O)cc2)n1>>Cc1cc(C(=O)NC2CCCCC2)n(-c2ccc(OC3CCN(C(=O)OC(C)(C)C)CC3)cc2)n1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150376189A1,Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1.O=C(O)c1cc(=O)[nH]c(=O)[nH]1>>O=C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cc(=O)[nH]c(=O)[nH]1,,CCOC(C)=O,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20040034034A1,COc1ccc(Cl)cc1S(=O)(=O)Cl.N>>COc1ccc(Cl)cc1S(N)(=O)=O,,C1CCOC1,,,,val
US20070219278A1,CC(=O)OCC(=O)N(CCO)Cc1ccccc1>>CC(=O)OCC(=O)N(CC=O)Cc1ccccc1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US03974141,CCOC(=O)NC(=N)N.CN=C=O>>CCOC(=O)NC(=N)NC(=O)NC,,C1COCCO1,,,,val
US20090186879A1,NCCCO.O=[N+]([O-])c1cccc([N+](=O)[O-])c1Cl>>O=[N+]([O-])c1cccc([N+](=O)[O-])c1NCCCO,,CCOC(C)=O,,C1CCOC1,CCN(CC)CC,val
US20110306618A1,CCOC(=O)C1CCC(N)CC1.CS(=O)c1nccc(-c2cnc3c(C(C)(C)O)cccn23)n1>>CCOC(=O)C1CCC(Nc2nccc(-c3cnc4c(C(C)(C)O)cccn34)n2)CC1,,CN1CCCC1=O,O,,,val
US20150126522A1,CCC(C)Nc1cc(Br)cc(C(=O)OC)c1C>>CCC(C)Nc1cc(Br)cc(C(=O)O)c1C,,C1CCOC1,O,[Li+].[OH-],,val
US20120202785A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(F)cc1N[C@@H]1CC[C@@H](C#N)CC1>>C[C@H](N)c1nc2ccc(F)cc2n1[C@@H]1CC[C@@H](C#N)CC1,,CC(=O)O,,,,val
US20100256092A1,CCOC(=O)CC1OB(O)c2cc(O)ccc21.Clc1ccnc(Cl)n1>>CCOC(=O)CC1OB(O)c2cc(Oc3ccnc(Cl)n3)ccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140005164A1,COC(=O)[C@@H]1CC[C@@H](CN)CC1.O=[N+]([O-])c1ccc(OC2CCCCO2)cc1F>>COC(=O)[C@@H]1CC[C@@H](CNc2cc(OC3CCCCO3)ccc2[N+](=O)[O-])CC1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090274655A1,COC(=O)c1sc(B(O)O)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C(C)C.Cc1cc(Br)cnc1N>>COC(=O)c1sc(-c2cnc(N)c(C)c2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20110269652A1,CCCCCCCCCCCCCCOCC(COCCCCCCCCCCCCCC)(CC(=O)N(C)C)CC(=O)N(C)C>>CCCCCCCCCCCCCCOCC(CCN(C)C)(CCN(C)C)COCCCCCCCCCCCCCC,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100249139A1,CCOC(=O)c1ccc(Cl)nc1C(F)(F)F.Cc1cc(C(O)(C(C)c2ccc(O)cc2Cl)C(F)(F)F)cn(C)c1=O>>Cc1cc(C(O)(C(C)c2ccc(Oc3ccc(C(=O)O)c(C(F)(F)F)n3)cc2Cl)C(F)(F)F)cn(C)c1=O,,CC(=O)N(C)C,,Cl,[Li+].[OH-],val
US05217976,CCOC(=O)c1cc2c(CC)nc(CC)cc2n(Cc2ccc(-c3ccccc3-c3nnn(C(c4ccccc4)(c4ccccc4)c4ccccc4)n3)cc2)c1=O.Cl>>CCOC(=O)c1cc2c(CC)nc(CC)cc2n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1=O.Cl,,ClCCl,,CO,,val
US20040106653A1,CCOC(=O)CBr.COC(=O)c1cc(S(=O)(=O)c2ccc(CCNC(=O)OC(C)(C)C)cc2)ccc1O>>CCOC(=O)COc1ccc(S(=O)(=O)c2ccc(CCNC(=O)OC(C)(C)C)cc2)cc1C(=O)OC,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120252792A1,NCC1CCN(c2ccc(Cl)cc2)C1=O.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C(NCC1CCN(c2ccc(Cl)cc2)C1=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,,val
US20100280071A1,CO[C@@H]1CC[C@@H](N2CCC(Nc3cc(C)ccc3N)CC2)CC1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CO[C@@H]1CC[C@@H](N2CCC(n3c(=O)[nH]c4ccc(C)cc43)CC2)CC1.Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140350019A1,COc1c(C)cc(-c2cccc(F)c2)cc1C(=O)Nc1c(C)ccc(O)c1C>>COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(C)ccc(O)c1C,,C1CCOC1,,,,val
US20030045560A1,COC(=O)C(Cc1ccccc1)Oc1ccc2cc(C[NH3+])ccc2c1Br.O=C(Cl)c1ccc(Oc2cc(Cl)cc(Cl)c2)o1>>COC(=O)C(Cc1ccccc1)Oc1ccc2cc(CNC(=O)c3ccc(Oc4cc(Cl)cc(Cl)c4)o3)ccc2c1Br,,ClCCl,,CCN(CC)CC,,val
US05506239,O=S(=O)(Cl)CCCCl.O=c1ccc2cc(OCCCCNCc3ccccc3)ccc2[nH]1>>O=c1ccc2cc(OCCCCN(Cc3ccccc3)S(=O)(=O)CCCCl)ccc2[nH]1,,CCN(CC)CC,,ClCCl,,val
US05965563,c1cnc2ncnc(Nc3ccc4c(c3)CCC4)c2c1>>c1cnc2ncnc(Nc3ccc4c(c3)CCC4)c2c1,,CO,,Cl,O=C([O-])[O-].[K+].[K+],val
US04622318,N#C/C=C/Cl.SC(c1ccccc1)(c1ccccc1)c1ccccc1>>N#C/C=C/SC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20120252805A1,CC1(C)OB(c2cnoc2)OC1(C)C.COc1cccc(-c2c(Br)sc3nc(C)cc(NS(=O)(=O)c4cccc(Cl)c4)c23)c1>>COc1cccc(-c2c(-c3cnoc3)sc3nc(C)cc(NS(=O)(=O)c4cccc(Cl)c4)c23)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20090186871A1,CC(C)I.NC(=O)c1[nH]c2ccc(O)cc2c1S(=O)(=O)N1CCOCC1>>CC(C)Oc1ccc2[nH]c(C(N)=O)c(S(=O)(=O)N3CCOCC3)c2c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20010021714A1,Cc1noc(NS(=O)(=O)c2ccsc2C(N)=O)c1Br.O=C(O)c1ccc2c(c1)OCO2>>Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NC(=O)c2ccc3c(c2)OCO3)c1Br,,C1CCOC1,O,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US06133253,CC(=O)Oc1cnc(F)c(C)c1>>Cc1cc(O)cnc1F,,[Na+],[OH-],,,val
US20040110787A1,CC(=O)c1cccnn1.CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C>>C=C(O[Si](C(C)C)(C(C)C)C(C)C)c1cccnn1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04496542,C[C@H](NC(=O)OCc1ccccc1)C(=O)N(CC(=O)O)c1ccsc1>>C[C@H](N)C(=O)N(CC(=O)O)c1ccsc1,,CC(=O)O,,Br,,val
US20120258952A1,CCOC(=O)C(Cl)C=O.N#Cc1ccc(N)nc1>>CCOC(=O)c1cnc2ccc(C#N)cn12,,CCO,,,,val
US20090247519A1,CC(C)(C)OC(=O)NCCNc1ccnc(Cl)n1.OB(O)c1ccccc1O>>NCCNc1ccnc(-c2ccccc2O)n1,,CCCCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US04367234,CCI.O=Cc1c(O)ccc2ccccc12>>CCOc1ccc2ccccc2c1C=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160096835A1,CCN(c1cccnc1)S(=O)(=O)c1ccc(NN)nc1.C[C@@H](N=C=S)c1ccccc1>>CCN(c1cccnc1)S(=O)(=O)c1ccc(NNC(=S)N[C@H](C)c2ccccc2)nc1,,C1CCOC1,O,CCN(CC)CC,,val
US07030085B2,C/C=C(/NC(=O)c1csc(-c2csc(-c3ccc4c(n3)-c3csc(n3)C(C(C)O)NC(=O)c3csc(n3)C(C(C)(C)O)NC(=O)c3csc(n3)/C(=C\C)NC(=O)C(C(C)O)NC(=O)c3csc-4n3)n2)n1)C(=O)NCC(C)O.CO>>C/C=C(/NC(=O)c1csc(-c2csc(-c3ccc4c(n3)-c3csc(n3)C(C(C)OC)NC(=O)c3csc(n3)C(C(C)(C)O)NC(=O)c3csc(n3)/C(=C\C)NC(=O)C(C(C)O)NC(=O)c3csc-4n3)n2)n1)C(=O)NCC(C)O,,CO,,CC(C)=O,,val
US20100016338A1,COCC(O)(C(Nc1cc(F)cc2[nH]c(=O)ccc12)c1ccc(OC)c(F)c1Cl)C(F)(F)F.COc1ncc(B(O)O)cn1.c1ccncc1>>CCOCC(O)(C(Nc1cc(F)cc2c1ccc(=O)n2-c1cnc(OC)nc1)c1ccc(OC)c(F)c1Cl)C(F)(F)F,,ClCCl,,O,,val
US20140142083A1,C=O.Cc1cc(C)c(CNC(=O)c2cc(N3CCNCC3)cc(N(C)C3CCCC3)c2C)c(=O)[nH]1>>Cc1cc(C)c(CNC(=O)c2cc(N3CCN(C)CC3)cc(N(C)C3CCCC3)c2C)c(=O)[nH]1,,CO,,[BH3-]C#N.[Na+],,val
US20150152108A1,C1CCNCC1.Cc1cc(-c2ccc3c(n2)N[C@H]2CCN3C2)ccn1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cc(-c2ccc3c(n2)N(C(=O)N2CCCCC2)[C@H]2CCN3C2)ccn1,,C1CCOC1,,CCN(CC)CC,,val
US05866567,O=C(Cl)CN1C(=O)c2ccccc2C1=O.O=C(Nc1cccc(CN2C(=O)[C@H]3CCC[C@H]3Nc3ccccc32)c1)OCc1ccccc1>>O=C(Nc1cccc(CN2C(=O)[C@H]3CCC[C@H]3N(C(=O)CN3C(=O)c4ccccc4C3=O)c3ccccc32)c1)OCc1ccccc1,,ClCCCl,O,O=C([O-])O.[Na+],,val
US20030153566A1,CNc1ccc(OC)cc1.COCCBr>>COCCN(C)c1ccc(OC)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20150351401A1,Br[Mg]C1CC1.O=CCc1ccc(Oc2ccc(Cl)cc2)cc1Cl>>OC(Cc1ccc(Oc2ccc(Cl)cc2)cc1Cl)C1CC1,,C1CCOC1,,,,val
US20050187266A1,Brc1ccc(Br)nc1.Cc1oc(-c2ccccc2)nc1CCO>>Cc1oc(-c2ccccc2)nc1CCOc1ccc(Br)cn1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20140235628A1,CC(C)(C)OC(=O)N1CCC(CBr)CC1.N#Cc1ccc(S)nc1>>CC(C)(C)OC(=O)N1CCC(CSc2ccc(C#N)cn2)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20040186132A1,CC(C)(C)OC(=O)N1CCC(=O)c2ccccc21.CI>>CC1CN(C(=O)OC(C)(C)C)c2ccccc2C1=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20110144179A1,CC(=O)O[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1N=[N+]=[N-]>>CC(C)(C)OC(=O)N1C[C@@H](N=[N+]=[N-])[C@H](O)C1,,C1CCOC1,CO,[Li+].[OH-],,val
US04140790,COc1ccccc1N1CCN(CCCO)CC1.Cl.O=C(Cl)C1c2ccccc2Oc2ccccc21>>COc1ccccc1N1CCN(CCCOC(=O)C2c3ccccc3Oc3ccccc32)CC1.Cl,,CC(C)=O,,,,val
US04668739,Br.C=CCc1cccc(C)c1OC(C)=O>>CC(=O)Oc1c(C)cccc1CCCBr,,CCCCCC,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20080167269A1,C1CNCCN1.C[Si](C)(C)CC[Si](C)(C)CCCOCC1CO1>>C[Si](C)(C)CC[Si](C)(C)CCCOCC(O)CN1CCNCC1,,CCO,,,,val
US04098812,CCOC(=O)c1cc(Cl)ccc1CBr.CO>>COCc1ccc(Cl)cc1C(=O)OC,,CO,,C[O-].[Na+],,val
US20090318517A1,CC(C)(C)OC(=O)N1OCC[C@H]1C(=O)NCc1cc(Cl)ccc1-n1cnnn1.Cl>>Cl.O=C(NCc1cc(Cl)ccc1-n1cnnn1)[C@@H]1CCON1,,CO,,,,val
US04377522,CN1C(=O)C(C)(C)N=C(c2ccccc2F)c2c1ccc(N)c2Cl.O=C(Cl)Cl>>CN1C(=O)C(C)(C)N=C(c2ccccc2F)c2c1ccc(N=C=O)c2Cl,,ClCCCl,,CCN(CC)CC,,val
US20130248765A1,CC(=O)/C=C(/C)[O-].CC(=O)/C=C(/C)[O-].CN(C)C=O.Oc1cccc2cccnc12.[Zn+2]>>[O-]c1cccc2cccnc12.[O-]c1cccc2cccnc12.[Zn+2],,CN(C)C=O,,,,val
US05380718,O=C(O)C(Cc1cccc(F)c1)c1ccc(F)cc1>>O=C1c2ccc(F)cc2CC1c1ccc(F)cc1,,CCCCCC,,O,,val
US04795748,CC(C)(C)[Si](OC(=O)c1cccc(O)c1)(c1ccccc1)c1ccccc1.S=C(Cl)Cl>>CC(C)(C)[Si](OC(=O)c1cccc(OC(=S)Cl)c1)(c1ccccc1)c1ccccc1,,CCOCC,,CCN(CC)CC,,val
US20150376192A1,CC(C)(C)c1nc(N2CC[C@H](O[Si](C)(C)C(C)(C)C)C2)c2cn[nH]c2n1.Cc1nonc1CCl>>Cc1nonc1Cn1ncc2c(N3CC[C@H](O[Si](C)(C)C(C)(C)C)C3)nc(C(C)(C)C)nc21,,CC(=O)N(C)C,,CC(C)(C)[O-].[K+],,val
US20090275570A1,BrCc1ccccc1.COC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)OC>>COC(=O)C(Cc1ccccc1)C[C@H](NC(=O)OC(C)(C)C)C(=O)OC,,C1CCOC1,,,,val
US20040266840A1,NO.O=Cc1c(Cl)cccc1-c1ccncc1>>ON=Cc1c(Cl)cccc1-c1ccncc1,,c1ccncc1,,Cl,,val
US20070219239A1,BrBr.CC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)cc([N+](=O)[O-])c1>>C[C@@H](NC(=O)c1cc(C(=O)CBr)cc([N+](=O)[O-])c1)c1ccc(F)cc1,,C1COCCO1,ClCCl,,,val
US20100261728A1,O=C(OCc1ccccc1)N1CCc2ccccc2C1c1ccc(C(F)(F)F)nc1>>FC(F)(F)c1ccc(C2NCCc3ccccc32)cn1,[Pd],CO,,,,val
US20110098310A1,Clc1cncc(Nc2ccc3[nH]ccc3c2)n1.OB(O)c1ccnc(F)c1>>Fc1cc(-c2cncc(Nc3ccc4[nH]ccc4c3)n2)ccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20150291595A1,COc1cc(N)cc(F)c1.O=C(Cl)c1c(Cl)ncnc1Cl>>COc1cc(F)cc(NC(=O)c2c(Cl)ncnc2Cl)c1,,ClCCl,,,,val
US20080275038A1,COC(=O)c1ccc(-c2nc3cc(-c4ccncc4F)c(-c4cccnc4)nc3[nH]2)cc1>>O=C(O)c1ccc(-c2nc3cc(-c4ccncc4F)c(-c4cccnc4)nc3[nH]2)cc1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20090118201A1,C=COC(C)=O.OCCc1ccc(Cc2cc(Br)ccc2Cl)cc1>>C=COCCc1ccc(Cc2cc(Br)ccc2Cl)cc1,,CCOC(C)=O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20050075363A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=c1[nH]sc2c1c(=O)c1cc(F)c(Br)cc1n2C1CC1>>CC(C)(C)OC(=O)n1sc2c(c(=O)c3cc(F)c(Br)cc3n2C2CC2)c1=O,CN(C)c1ccncc1,CN(C)C=O,,O,,val
US04339583,N#Cc1ccc(CBr)cc1.Oc1cccnc1Cc1ncc[nH]1>>N#Cc1ccc(COc2cccnc2Cc2ncc[nH]2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20160002209A1,COC(OC)N(C)C.COCC(=O)C(=NNc1ccc(-n2cccn2)cc1F)c1ccnn1-c1ccccc1>>COc1cn(-c2ccc(-n3cccn3)cc2F)nc(-c2ccnn2-c2ccccc2)c1=O,,CC(=O)N(C)C,,O,,val
US05536717,C#CCBr.O=C1Nc2ccccc2N2CCc3cccc1c32>>C#CCN1C(=O)c2cccc3c2N(CC3)c2ccccc21,,CN(C)C=O,,[Na+].[OH-],,val
US20100009975A1,CN(CCN1CCSc2cc(N)ccc21)C(=O)OC(C)(C)C.N=C(SCc1ccccc1)c1ccco1>>CN(CCN1CCSc2cc(NC(=N)c3ccco3)ccc21)C(=O)OC(C)(C)C,,CCO,,Br,,val
US20060178514A1,CCN(CC1CCCC1)c1nc2c(cc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c(C)nn2C.COC(=O)Cl>>CCN(CC1CCCC1)c1nc2c(cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)OC)c(C)nn2C,,C1CCOC1,,O,O=C([O-])[O-].[K+].[K+],val
US20060142265A1,CCCc1c(C=O)oc2ccccc12.CN>>CCCc1c(CNC)oc2ccccc12,,CO,,[BH4-].[Na+],,val
US20060063759A1,CC1(C)OB(c2ccc3[nH]c(=O)[nH]c3c2)OC1(C)C.Clc1ccc2c(c1)OCc1ccccc1C2=CBr>>O=c1[nH]c2ccc(C=C3c4ccccc4COc4cc(Cl)ccc43)cc2[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20100305133A1,CCCC[Sn](CCCC)(CCCC)c1cccs1.COC(=O)c1c(OC)c(Br)cc2[nH]c(=O)cnc12>>COC(=O)c1c(OC)c(-c2cccs2)cc2[nH]c(=O)cnc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20050256116A1,CCOC(=O)[C@H](Cc1ccc(-c2cccc(C=O)c2)cc1)NC(=O)OC(C)(C)C.CN>>CCOC(=O)[C@H](Cc1ccc(-c2cccc(CNC)c2)cc1)NC(=O)OC(C)(C)C,,CO,,Cl,[BH3-]C#N.[Na+],val
US20130072467A1,CC(C)(CO)CNC1=NC(=O)S/C1=C\C1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1.O=C(O)/C=C/C(=O)O>>CC(C)(CO)CNC1=NC(=O)S/C1=C\C1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1.O=C(O)/C=C/C(=O)O,,CCO,,,,val
US20040009995A1,COC(=O)CCCCC(=O)Nc1cccc(C)c1-c1cccc(S(=O)(=O)c2cc(C(=N)NC(=O)OC(C)(C)C)sc2SC)c1>>CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2NC(=O)CCCCC(=O)O)c1,,CCOC(C)=O,,CO,[Li+].[OH-],val
US20140148466A1,CC(C)(C)C(N)C(=O)c1ccc(C#N)cc1.Cc1cccc(N2CCNCC2)n1.O=C(n1ccnc1)n1ccnc1>>Cc1cccc(N2CCN(C(=O)NC(C(=O)c3ccc(C#N)cc3)C(C)(C)C)CC2)n1,,CC#N,,Cl,,val
US20090018103A1,CNC[C@H](CC(C)(C)OC)NC(=O)OC(C)(C)C.C[Si](C)(C)CCOC(=O)ON1C(=O)CCC1=O>>COC(C)(C)C[C@@H](CN(C)C(=O)OCC[Si](C)(C)C)NC(=O)OC(C)(C)C,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20110046110A1,COC(=O)c1cccc(CN)c1N.O=Cc1cccnc1>>COC(=O)c1cccc2c1NC(c1cccnc1)NC2,,C1COCCO1,,CC(=O)O,,val
US20100160325A1,COc1cc(Nc2nc(Cl)ncc2Br)n[nH]1.C[C@H](N)c1ncc(F)cn1>>COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Br)n[nH]1,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20140038969A1,C=C[Mg]Br.O=Cc1c(F)ccc(Cl)c1F>>C=CC(O)c1c(F)ccc(Cl)c1F,,C1CCOC1,,,,val
US04146625,CCOC(=O)c1cn(CC(F)(F)F)c2c(C)cc(F)cc2c1=O>>Cc1cc(F)cc2c(=O)c(C(=O)O)cn(CC(F)(F)F)c12,,Cl,,,,val
US20080312226A1,COc1ncccc1C(=O)O.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>COc1ncccc1NC(=O)N1CCN(c2nc(-c3ccccc3)ns2)CC1,,Cc1ccccc1,O,CCN(CC)CC,,val
US20090082372A1,COc1ccccc1C#CC1(OC(C)C)C=C(C(=O)O)C=CC1.NC(CO)Cc1c[nH]c2ncccc12>>COc1ccccc1C#Cc1ccc(OC(C)C)c(C(=O)NC(CO)Cc2c[nH]c3ncccc23)c1,,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US06172076B2,CCOC(=O)C1(Nc2cccc(C)c2)CCN(Cc2ccccc2)CC1>>Cc1cccc(NC2(CO)CCN(Cc3ccccc3)CC2)c1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110288299A1,CCBr.CCOC(=O)c1cnc(Nc2cc3c4c(c2)CCCC4(C)CCC3)nc1>>CCN(c1cc2c3c(c1)CCCC3(C)CCC2)c1ncc(C(=O)O)cn1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20040152742A1,C1CCNC1.O=[N+]([O-])c1ccc(CBr)c(Cl)c1>>O=[N+]([O-])c1ccc(CN2CCCC2)c(Cl)c1,,CC#N,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20080262042A1,O=C(Cl)c1cccc(S(=O)(=O)Cl)c1.OCc1ccccc1>>O=C(OCc1ccccc1)c1cccc(S(=O)(=O)Cl)c1,,C1CCOC1,O,c1ccncc1,,val
US20090054525A1,Cc1cc(NC(=O)[C@@](C)(O)CBr)ccc1C#N>>Cc1cc(NC(=O)[C@@]2(C)CO2)ccc1C#N,,Cc1ccccc1,,[Na+].[OH-],,val
US20100048604A1,CC(O)C#Cc1ccc2cc(N(C)C)ccc2c1.CO.Oc1ccccc1>>CC(=O)c1cc(=O)oc2cc3c(cc12)CCCN3,,ClC(Cl)Cl,,,,val
US03989707,Fc1ccc(C(CCCCl)c2ccc(F)cc2)cc1.O=c1[nH]c2cc(Br)ccc2n1C1CCNCC1>>O=c1[nH]c2cc(Br)ccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,,CC(=O)CC(C)C,O,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20070004772A1,Clc1nccc(I)c1Br.OB(O)c1ccc(Cl)cc1>>Clc1ccc(-c2ccnc(Cl)c2Br)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20070293470A1,COC(=O)c1ccc2c(c1)CCC1(CCN(Cc3ccc(OC)cc3)C1=O)C2>>COC(=O)c1ccc2c(c1)CCC1(CCNC1=O)C2,,CC#N,O,,,val
US20030114432A1,CCOC(=O)c1nn(-c2ccc(F)cc2)c2c1CN(C(C)=O)c1ccc([N+](=O)[O-])cc1-2>>CCOC(=O)c1nn(-c2ccc(F)cc2)c2c1CNc1ccc([N+](=O)[O-])cc1-2,,CCO,Cl,,,val
US05055464,CC(C)C1Sc2ccccc2N(CC(N)=O)C(=O)C1N.O=C(ON1C(=O)CCC1=O)c1cc2ccccc2[nH]1>>CC(C)C1Sc2ccccc2N(CC(N)=O)C(=O)C1NC(=O)c1cc2ccccc2[nH]1,,CN(C)C=O,,,,val
US20140323474A1,O=C(NC1=N[C@@]2(c3cc(CNCC(F)(F)F)c(F)cc3F)CO[C@@H](CF)C[C@H]2CS1)c1ccccc1>>NC1=N[C@@]2(c3cc(CNCC(F)(F)F)c(F)cc3F)CO[C@@H](CF)C[C@H]2CS1,,CO,,C1CCC2=NCCCN2CC1,,val
US20120184531A1,CC(C)(C)OC(=O)N1CCc2oc3ccc(S(=O)(=O)c4ccc([N+](=O)[O-])cc4)cc3c2C1>>CC(C)(C)OC(=O)N1CCc2oc3ccc(S(=O)(=O)c4ccc(N)cc4)cc3c2C1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20130267499A1,C=CCN.COc1ccc(Cn2cc(C(C)=O)c(Cl)n2)cc1>>C=CCNc1nn(Cc2ccc(OC)cc2)cc1C(C)=O,,CCOC(C)=O,O,,,val
US04346087,CC(C)CCCCCCCCCCCCCCC(=O)O.CCOC(=O)CC(C)=O.NCCNCCN>>CC1=NCCN(CCNC(=O)CCCCCCCCCCCCCCC(C)C)C(=O)C1,,CCO,,O,,val
US20090028787A1,C1CCNC1.COc1ccc2nc(-c3ccc(F)nc3)sc2c1>>COc1ccc2nc(-c3ccc(N4CCCC4)nc3)sc2c1,,O,,,,val
US04812483,CC(C)(C=O)COCc1cccc(Oc2ccccc2)c1.ClC(Cl)(Cl)Cl>>CC(C)(C=C(Cl)Cl)COCc1cccc(Oc2ccccc2)c1,[Zn],,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060025597A1,CC(=O)OCC(=O)Cl.Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O>>CC(=O)OCC(=O)Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,,C1CCOC1,,,,val
US05681842,O=[N+]([O-])c1ccc(N(S(=O)(=O)C(F)(F)F)S(=O)(=O)C(F)(F)F)c(Oc2ccc3ccccc3c2)c1>>O=[N+]([O-])c1ccc(NS(=O)(=O)C(F)(F)F)c(Oc2ccc3ccccc3c2)c1,,C1CCOC1,,[Na+].[OH-],,val
US04464300,NN.O=S1(=O)CCC(=S)Nc2ccc(Cl)cc2C1c1ccccc1F>>NNC1=Nc2ccc(Cl)cc2C(c2ccccc2F)S(=O)(=O)CC1,,C1CCOC1,,O,,val
US20040235867A1,C1CO1.CC(C)(C)OC(=O)Nc1ccnc(Cl)c1>>CC(C)(C)OC(=O)Nc1ccnc(Cl)c1CCO,,C1CCOC1,,[Li]C(C)(C)C,,val
US20140142122A1,Cc1cc(C)n2nc(S(C)(=O)=O)nc2n1.OCCOc1ccc(Cl)cc1>>Cc1cc(C)n2nc(OCCOc3ccc(Cl)cc3)nc2n1,,C1CCOC1,,[H-].[Na+],,val
US04341756,CC1(C)OCC=CCO1.O=C(OO)c1cccc(Cl)c1>>CC1(C)OCC2OC2CO1,,ClCCl,,,,val
US20020082265A1,CC1(C)CCC(C)(C)c2cc(C=O)c(Br)cc21.OCCO>>CC1(C)CCC(C)(C)c2cc(C3OCCO3)c(Br)cc21,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20100267561A1,Cc1c[nH]nc1I.Fc1ccc(C(F)(F)F)cc1>>Cc1cn(-c2ccc(C(F)(F)F)cc2)nc1I,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110112076A1,CC(=O)Oc1ccc2cc(S(=O)(=O)N(CCC(C)C)[C@@H](C(=O)OC(C)(C)C)C(C)C)ccc2c1>>CC(C)CCN([C@@H](C(=O)OC(C)(C)C)C(C)C)S(=O)(=O)c1ccc2cc(O)ccc2c1,,CCO,O,O=C([O-])[O-].[K+].[K+],,val
US05856274,CSc1c(F)cccc1Cl.O=C=O>>CSc1c(Cl)ccc(C(=O)O)c1F,,C1CCOC1,CCCCCC,,,val
US20140336177A1,CC(C)(C)OC(=O)Cc1ccnc(N)c1.CCOC(OCC)OCC.[N-]=[N+]=[N-]>>CC(C)(C)OC(=O)Cc1ccnc(-n2cnnn2)c1,,CC(=O)O,O,O=C([O-])O.[Na+],,val
US20110294793A1,CC(C)C=O.NCc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cc(Cl)cc(Cl)c2O)c1>>CC(C)CNCc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cc(Cl)cc(Cl)c2O)c1,,CO,,[BH4-].[Na+],,val
US20040209865A1,OCC#Cc1ccc(-c2ccc(Cl)cc2)cn1.Oc1ccc(CN2CCCC2)cc1>>Clc1ccc(-c2ccc(C#CCOc3ccc(CN4CCCC4)cc3)nc2)cc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05942546,Cc1ccc(S(=O)(=O)Cl)cc1.N>>Cc1ccc(S(N)(=O)=O)cc1,,ClCCl,,,,val
US20070043023A1,Cc1nccnc1C.OO>>Cc1ncc[n+]([O-])c1C,,CC(=O)O,,,,val
US20130018033A1,N.Nc1c(F)ccc(NS(=O)(=O)c2ccco2)c1F.O=C(Cl)c1cccc2c(Cl)ncnc12>>Nc1ncnc2c(C(=O)Nc3c(F)ccc(NS(=O)(=O)c4ccco4)c3F)cccc12,,C1COCCO1,ClC(Cl)Cl,,,val
US20110105761A1,CCCBr.O=[N+]([O-])c1ccc(-n2ccnc2)cc1>>CCCn1cc[n+](-c2ccc([N+](=O)[O-])cc2)c1.[Br-],,C1CCOC1,,,,val
US20020055631A1,CC(C)(C)[Si](C)(C)Cl.COC(=O)c1ccc(-c2ccc(CO)cc2OC)cc1>>COC(=O)c1ccc(-c2ccc(CO[Si](C)(C)C(C)(C)C)cc2OC)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040044052A1,CCn1c(=O)oc2cc([N+](=O)[O-])cc(F)c21>>CCn1c(=O)oc2cc(N)cc(F)c21,[Fe],CCO,O,[Cl-].[NH4+],,val
US05112966,C=C(C(=O)OCc1ccccc1)[C@@H]1[C@@H]([C@@H](C)OC(=O)OCc2ccccc2)C(=O)N1C(Cc1ccc(OC)cc1)Cc1ccc(OC)cc1>>COc1ccc(CC(Cc2ccc(OC)cc2)N2C(=O)[C@H]([C@@H](C)OC(=O)OCc3ccccc3)[C@H]2C(C)C(=O)OCc2ccccc2)cc1,Cl[Ni]Cl,CCOC(C)=O,CO,[BH4-].[Na+],,val
US04730069,Cc1ccc(S(=O)(=O)OCC(CO)(CN=[N+]=[N-])CN=[N+]=[N-])cc1>>[N-]=[N+]=NCC1(CN=[N+]=[N-])COC1,,C1COCCO1,,,,val
US20030181690A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CO[C@@H]1O[C@H](COCc2ccc(Cl)cc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1O>>CO[C@@H]1O[C@H](COCc2ccc(Cl)cc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1O[Si](C)(C)C(C)(C)C,,ClCCl,,Cc1cccc(C)n1,,val
US20110076291A1,CC(C)NN.CCOC(=O)/N=C(/C)OCC>>Cc1nn(C(C)C)c(=O)[nH]1,,Cc1ccccc1,,CCN(CC)CC,Cl,val
US20090318690A1,CC(C)(C)[Si](C)(C)Cl.Cc1noc2c(CO)c(I)ccc12>>Cc1noc2c(CO[Si](C)(C)C(C)(C)C)c(I)ccc12,,CCOC(C)=O,CN(C)C=O,O,c1c[nH]cn1,val
US20020128252A1,CCCCC1(CC)CS(=O)(=O)c2ccc(N(C)C)cc2C(c2cccc(NC(=O)CCCCBr)c2)C1O.COc1ccc(C2C(CCC(O)c3ccccc3)C(=O)N2c2ccc(CN)cc2)cc1>>CCCCC1(CC)CS(=O)(=O)c2ccc(N(C)C)cc2C(c2cccc(NC(=O)CCCCNCc3ccc(N4C(=O)C(CCC(O)c5ccccc5)C4c4ccc(OC)cc4)cc3)c2)C1O,,CN(C)C=O,,,,val
US20100261736A1,CC(O)CCCCC(=O)OC(C)(C)C.CCc1ccc(-c2c(-c3ccccc3)oc3nccc(Cl)c23)cc1>>CCc1ccc(-c2c(-c3ccccc3)oc3nccc(O[C@H](C)CCCCC(=O)OC(C)(C)C)c23)cc1,,CCCCCC,CN(C)C=O,Cl,O,val
US20050113580A1,FC(F)(F)c1cccc(CNCC(c2ccccc2)c2ccccc2)c1Cl.OCCCBr>>OCCCN(Cc1cccc(C(F)(F)F)c1Cl)CC(c1ccccc1)c1ccccc1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20160031892A1,Cc1ccc(CN)cc1.O=C(O)C1CN(c2ncnn3cc(Br)cc23)C1>>Cc1ccc(CNC(=O)C2CN(c3ncnn4cc(Br)cc34)C2)cc1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130072467A1,CN(C)C(=O)[C@@H]1CCCN1.O=C1NC(=S)CS1>>CN(C)C(=O)[C@@H]1CCCN1C1=NC(=O)SC1,,CCO,,CCN(CC)CC,Cl,val
US05025031,O=C=NS(=O)(=O)Cl.Oc1cccc(C(F)(F)F)c1>>NS(=O)(=O)Oc1cccc(C(F)(F)F)c1,,Cc1ccccc1,,,,val
US20110269740A1,COC(=O)c1cc(C(N)=O)n(N)c1.O=C1OC(=O)C(c2ccc(F)cc2)O1>>COC(=O)c1cc(C(N)=O)n(NC(=O)C(O)c2ccccc2)c1,,C1CCOC1,,,,val
US20050288273A1,CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCC(C(=O)c2cc4ccccc4o2)C3=O)C(=O)O1.NN>>CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCc2cnn(-c4cc5ccccc5o4)c2-3)C(=O)O1,,CCO,,O,,val
US20140179743A1,C=O.CCOc1ccc(/C=C2\SC(=O)N(CCN)C2=O)cc1.ClCCCl>>CCOc1ccc(/C=C2\SC(=O)N(CCN(C)C)C2=O)cc1,,ClCCCl,,CCN(CC)CC,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060229286A1,CC(=O)N1CCc2cc(C(=O)O)ccc21>>CC(=O)n1ccc2cc(C(=O)O)ccc21,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20130310379A1,CC1(C)CC(N)CC(C)(C)N1.CN(c1ccccc1)c1ccc(C(=O)O)cc1>>CN(c1ccccc1)c1ccc(C(=O)NC2CC(C)(C)NC(C)(C)C2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100249124A1,CC(c1ccc(O)cc1Cl)C(O)(c1ccc2c(c1)N(C)C(=O)CO2)C(F)(F)F.COC(=O)c1ccc(Cl)nc1>>COC(=O)c1ccc(Oc2ccc(C(C)C(O)(c3ccc4c(c3)N(C)C(=O)CO4)C(F)(F)F)c(Cl)c2)nc1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20110217311A1,COC1CCCCC1O.O=[N+]([O-])c1ccc(F)cc1O>>CO[C@H]1CCCC[C@H]1Oc1cc(F)ccc1[N+](=O)[O-],,C1CCOC1,ClCCl,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080064699A1,C1COCCN1.CS(=O)(=O)OCCn1ccs/c1=N\C(=O)C12CC3CC(CC(C3)C1)C2>>O=C(/N=c1\sccn1CCN1CCOCC1)C12CC3CC(CC(C3)C1)C2,,CC#N,ClCCl,[I-].[K+],,val
US20110053940A1,OCc1cc(Br)cc(I)c1>>O=Cc1cc(Br)cc(I)c1,,CCOCC,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20150045349A1,CC1(C)OB(c2cn(-c3ccccc3Cl)c(=O)c3c(N)n[nH]c23)OC1(C)C.Clc1ncccn1>>Nc1n[nH]c2c(-c3ncccn3)cn(-c3ccccc3Cl)c(=O)c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20120101039A1,COC(=O)COc1ccc(C#CCN[C@H](C)c2cccc3ccccc23)cc1>>C[C@@H](NCCCc1ccc(OCC(=O)O)cc1)c1cccc2ccccc12,,CO,,[Na+].[OH-],,val
US20140155391A1,COC(=O)c1ccc(F)c(N(CCN2CCOCC2)S(C)(=O)=O)c1.Cl>>CS(=O)(=O)N(CCN1CCOCC1)c1cc(C(=O)O)ccc1F.Cl,,C1COCCO1,,,,val
US20120309751A1,O=C1NC(=O)[C@H]2CC=CC[C@@H]12>>O=C1NC(=O)C2CCCCC12,[Pd],CO,,,,val
US20110150864A1,CSC1=NC(=O)CS1.O=C(O)C1CCNCC1>>O=C1CSC(N2CCC(C(=O)O)CC2)=N1,,CO,,,,val
US20100190766A1,CC(C)(C)[Si](C)(C)OCc1ccc(C#C[Si](C)(C)C)cc1>>C#Cc1ccc(CO[Si](C)(C)C(C)(C)C)cc1,,CO,,CC(=O)O,[K+].[OH-],val
US20130165423A1,Brc1ccc2cn[nH]c2c1.C[C@H](Cl)c1ccc(Cl)cc1Cl>>C[C@H](c1ccc(Cl)cc1Cl)n1ncc2ccc(Br)cc21,,CCOC(C)=O,CN1CCCC1=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160009704A1,CC(C)(C)OC(=O)c1cn(CC(F)CCc2nnc(C(=O)NCc3cc(C(F)(F)F)ccn3)s2)nn1>>O=C(O)c1cn(CC(F)CCc2nnc(C(=O)NCc3cc(C(F)(F)F)ccn3)s2)nn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020193402A1,O=C1C[C@@]2(c3ccccc3)[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC[C@@H]1N2Cc1ccccc1>>O=C1C[C@]2(c3ccccc3)N[C@H]1CC[C@H]2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1,[Pd],,,,,val
US20060074115A1,CCOC(=O)CCc1cccc(OCCCOc2cccc(C(OCc3ccc(OC)cc3)(C(F)(F)F)C(F)(F)F)c2)c1>>CCOC(=O)CCc1cccc(OCCCOc2cccc(C(O)(C(F)(F)F)C(F)(F)F)c2)c1,[Pd],CCOC(C)=O,,,,val
US20110152240A1,C1CCNC1.O=Cc1cnn2c(NC3CC3)cc(-c3ccc(CBr)s3)nc12>>O=Cc1cnn2c(NC3CC3)cc(-c3ccc(CN4CCCC4)s3)nc12,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060173019A1,COCN(c1cc(Cl)cnc1C(=O)c1ccccc1Br)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>O=C(c1ccccc1Br)c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1,,C1COCCO1,Cl,O,,val
US20160264552A1,COC(=O)C1CC(NC(=O)OCc2ccccc2)CN(C(=O)OC(C)(C)C)C1>>COC(=O)C1CC(N)CN(C(=O)OC(C)(C)C)C1,[Pd],CO,,,,val
US05856503,COc1ccc2c(-c3ccc(Br)cc3)coc2c1>>Oc1ccc2c(-c3ccc(Br)cc3)coc2c1,,ClCCl,,BrB(Br)Br,,val
US20120142647A1,CCCNc1nc(NCCC)nc(N(C)OC)n1.O=S(=O)(O)O>>CCCNc1nc(NCCC)nc(N(C)OC)n1.O=S(=O)(O)O,,C1COCCO1,,,,val
US20110105502A1,CCCS(=O)(=O)NCCOc1ccc2c(c1)C(C1(c3ccc(Cl)cc3)CCC1)[NH2+]CC2.[Cl-]>>CCCS(=O)(=O)NCCOc1ccc2c(c1)C(C1(c3ccccc3)CCC1)[NH2+]CC2.[Cl-],[Pd],CO,,CCN(CC)CC,[H][H],val
US20080085926A1,COc1ccc(CCl)cc1.O=C(O)Cc1cccc(Br)c1>>COc1ccc(COC(=O)Cc2cccc(Br)c2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160185779A1,CNc1cccc(Cl)c1.C[C@H]1Cc2[nH]nc(-c3cccs3)c2CN1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C[C@H]1Cc2[nH]nc(-c3cccs3)c2CN1C(=O)N(C)c1cccc(Cl)c1,,ClCCl,,O,,val
US20120264748A1,Cc1ccc(S(=O)(=O)n2ccc3c(CN4C(=O)CCCC45CCNCC5)cccc32)cc1.Clc1nc2ccccc2o1>>Cc1ccc(S(=O)(=O)n2ccc3c(CN4C(=O)CCCC45CCN(c4nc6ccccc6o4)CC5)cccc32)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04959092,CON(C)C(=O)Nc1cccc(O)c1.Cc1ccc(S(=O)(=O)OCCc2ccc3c(c2)CC(C)O3)cc1>>CON(C)C(=O)Nc1ccccc1OCCc1ccc2c(c1)CC(C)O2,,O,,CN(C)C=O,[H-].[Na+],val
US20020013460A1,CNC(=O)c1cccnc1C=C(O)c1ccc(OC)cc1>>COc1ccc(-c2cc3ncccc3c(=O)[nH]2)cc1,,C1COCCO1,,N,,val
US04411898,C#CCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nnnn3CCC(=O)O)CS[C@H]12)c1csc(NC(=O)C(F)(F)F)n1>>C#CCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nnnn3CCC(=O)O)CS[C@H]12)c1csc(N)n1,,O,,Cl,CC(=O)[O-].[Na+],val
US20160237075A1,CC(C)(C)OC(=O)N1CCCC(c2nc(-c3ccc(Oc4ccccc4)cc3)c(C(=O)O)s2)C1.CN(C)C(On1nnc2cccnc21)=[N+](C)C>>CC(C)(C)OC(=O)N1CCCC(c2nc(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)s2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20040122063A1,COC1C[C@@H](N)[C@H](N)C1.O=C(Oc1ccc([N+](=O)[O-])cc1)c1cc2cc(Cl)ccc2[nH]1>>COC1C[C@@H](N)[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)C1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20100280011A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)OCc1ccc(C(CN)C(=O)Nc2ccc3cnccc3c2)s1>>CC(C)(C)OC(=O)NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(CO[Si](C)(C)C(C)(C)C)s1,,ClCCl,,,,val
US20100168188A1,Cc1ccc(S(=O)(=O)n2cc3c4c(ccc3n2)C2=C(Cl)C(=O)[C@@H]3CC[C@@]2(C4)C3)cc1.Cc1ccc(S(=O)(=O)n2ncc3c4c(ccc32)C2=C(Cl)C(=O)[C@@H]3CC[C@@]2(C4)C3)cc1>>Cc1ccc(S(=O)(=O)n2cc3c4c(ccc3n2)C2=C(Cl)[C@H](O)[C@@H]3CC[C@@]2(C4)C3)cc1.Cc1ccc(S(=O)(=O)n2ncc3c4c(ccc32)C2=C(Cl)[C@H](O)[C@@H]3CC[C@@]2(C4)C3)cc1,,CCO,,[BH4-].[Na+],,val
US20060183754A1,CC(C)(C)O.CCOC(=O)C(C)(C)Oc1ccc(C(C)C=O)cc1C>>CCOC(=O)C(C)(C)Oc1ccc(C(C)C(=O)O)cc1C,,CC(C)(C)O,O,CC=C(C)C,[Na+].[O-]Cl,val
US20060122250A1,COC(=O)[C@H](N)Cc1cc(C)c2[nH]ncc2c1.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O.O=C1Nc2ccccc2CN1C1CCNCC1>>COC(=O)[C@@H](Cc1cc(C)c2[nH]ncc2c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20090253758A1,CC(=O)Nc1ccc(-c2nnc([C@H](Nc3ccc(C#N)c(Cl)c3C)[C@H](C)O[Si](C)(C)C(C)(C)C)o2)cc1>>CC(=O)Nc1ccc(-c2nnc([C@H](Nc3ccc(C#N)c(Cl)c3C)[C@H](C)O)o2)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04549019,CCOCCOC(=O)CC=NC(=O)OC.N=C(N)N>>COC(=O)Nc1cc(=O)[nH]c(N)n1,,CO,,Cl,[Na],val
US20110009454A1,NCc1ccc(Oc2cccc(C(F)(F)F)c2)cc1.Nc1nc(F)ccc1C(=O)O>>Nc1nc(F)ccc1C(=O)NCc1ccc(Oc2cccc(C(F)(F)F)c2)cc1,,CN(C)C=O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US05872118,O=C(O)CC(CC(=O)O)c1cccc(F)c1>>O=C(O)CC1CC(=O)c2ccc(F)cc21,,O,,,,val
US05840732,O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCCl)CCS2(=O)=O.Sc1cccc2nccn12>>O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCSc1cccc3nccn13)CCS2(=O)=O,,CN(C)C=O,O,[H-].[Na+],,val
US20070072847A1,CCOC(=O)CCC1CCN(C2CCNCC2)CC1.Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc(C)c1O>>CCOC(=O)CCC1CCN(C2CCN(C(=O)[C@@H](Cc3cc(C)c(O)c(C)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20130178625A1,CCCC[Sn](CCCC)(CCCC)N=[N+]=[N-].N#Cc1cccc(-n2c(=O)c(=O)[nH]c3c4ccccc4ccc32)c1>>O=c1[nH]c2c3ccccc3ccc2n(-c2cccc(-c3nnn[nH]3)c2)c1=O,,Cc1ccccc1,,[Na+].[OH-],,val
US20140073627A1,CCc1cc(Br)ccc1S(=O)(=O)N(C)Cc1cc(C(=O)O)co1.NCc1cccc(CN2CCCC2)c1>>CCc1cc(Br)ccc1S(=O)(=O)N(C)Cc1cc(C(=O)NCc2cccc(CN3CCCC3)c2)co1,,ClCCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20140350030A1,CC(C)(C)OC(=O)NC12CC3CC(CC(C#Cc4cnccn4)(C3)C1)C2>>NC12CC3CC(C1)CC(C#Cc1cnccn1)(C3)C2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20010034343A1,COc1ccc(-n2cnnn2)cc1C(=O)N1CC[C@](CCOS(C)(=O)=O)(c2ccccc2)C1.c1ccc2c(c1)nc(N1CCCNCC1)n2CCOCC1CC1>>COc1ccc(-n2cnnn2)cc1C(=O)N1CC[C@](CCN2CCCN(c3nc4ccccc4n3CCOCC3CC3)CC2)(c2ccccc2)C1,,CC#N,,CCN(CC)CC,[I-].[Na+],val
US05091295,NNc1ccccc1.O=Cc1ccccc1S(=O)(=O)[O-].[Na+]>>O=S(=O)([O-])C1C=CC=CC1=NNc1ccccc1.[Na+],,CO,,,,val
US20140128374A1,Cc1cc(O)ccc1-c1c(C)ncnc1C.O=C(OO)c1cccc(Cl)c1>>Cc1cc(O)ccc1-c1c(C)nc[n+]([O-])c1C,,ClCCl,,,,val
US03985730,CCN1c2ccccc2CC(C#N)(CCCN(C)C)c2ccccc21.Cl>>CCN1c2ccccc2CC(C#N)(CCCN(C)C)c2ccccc21.Cl,,CC(C)O,,,,val
US20120214840A1,C#CC(O)(CC)C(F)(F)F.CCOC(=O)c1cn2cc(CN=[N+]=[N-])ccc2c1-c1ccc(F)cc1>>CCOC(=O)c1cn2cc(Cn3cc(C(O)(CC)C(F)(F)F)nn3)ccc2c1-c1ccc(F)cc1,I[Cu]I,C1CCOC1,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20110009454A1,N#Cc1cccc(F)c1.Oc1ccc(OC(F)(F)F)cc1>>N#Cc1cccc(Oc2ccc(OC(F)(F)F)cc2)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
USH0001142,CCOC(=O)[C@@H]1CC(OCC)(OCC)[C@H]1C(=O)OCC>>CCOC1(OCC)C[C@@H](C(=O)O)[C@@H]1C(=O)O,,C1CCOC1,,CO,[K+].[OH-],val
US20090054422A1,BrCCCBr.N#Cc1ccc(O)c(C#N)c1>>N#Cc1cccc(C#N)c1OCCCBr,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110178132A1,N#Cc1cc(-c2cc(C(F)(F)F)ccc2Cl)ccn1.NO>>NC(=NO)c1cc(-c2cc(C(F)(F)F)ccc2Cl)ccn1,,CCO,,Cl,O=C([O-])O.[Na+],val
US06831106B1,CCOC(=O)c1ccc(I)cc1.COCOc1cccc(B(O)O)c1C>>COC(=O)c1ccc(-c2cccc(O)c2C)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150246902A1,CN(C)C=Cc1ncc(Br)cc1[N+](=O)[O-]>>Brc1cnc2cc[nH]c2c1,[Fe],CC(=O)O,,CCOC(C)=O,,val
US05102890,CC(=O)N(C)CCCC(=O)O.O=C1c2ccccc2C(Cl)N1c1ccc2ccc(Cl)nc2n1>>CC(=O)N(C)CCCC(=O)OC1c2ccccc2C(=O)N1c1ccc2ccc(Cl)nc2n1,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US04191694,C=[N+]=[N-].CC(C)=CCC(C)(C)[C@H](O)/C=C/[C@@H]1[C@H]2C[C@@H](CCCCC(=O)O)O[C@H]2C[C@H]1O>>COC(=O)CCCC[C@@H]1C[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)C(C)(C)CC=C(C)C)O1,,ClCCl,,,,val
US20150344473A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.N#Cc1cc(Br)ccc1OC1CCCOC1>>CC1(C)OB(c2ccc(OC3CCCOC3)c(C#N)c2)OC1(C)C,,C1COCCO1,,ClCCl,CC(=O)[O-].[K+],val
US20140275040A1,CN1CCNCC1.O=C(O)c1ccc(I)cc1>>CN1CCN(C(=O)c2ccc(I)cc2)CC1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20100016311A1,CCOC(=O)c1cc(C=O)cn1C.O=P([O-])([O-])Cc1cnc2ccccc2c1>>CCOC(=O)c1cc(/C=C/c2cnc3ccccc3c2)cn1C,,C1CCOC1,,O,[H-].[Na+],val
US20120028919A1,Cc1ccc2oc(=O)[nH]c2c1.O=[N+]([O-])O>>Cc1cc2[nH]c(=O)oc2cc1N,[Pd],CO,,,,val
US20040059100A1,CC(=O)c1c(O)cccc1O.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>O=c1cc(-c2ccc([N+](=O)[O-])cc2)oc2cccc(O)c12,,C1CCOC1,,Cl,[Li+].[OH-],val
US20080167330A1,CS(C)(=N)=O.O=C(Cl)c1cccc([N+](=O)[O-])c1>>CS(C)(=O)=NC(=O)c1cccc([N+](=O)[O-])c1,,ClCCl,,CCN(CC)CC,,val
US20110319429A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=[N+]([O-])c1ccc(NCc2ccccn2)cc1>>CC(C)(C)OC(=O)N(Cc1ccccn1)c1ccc([N+](=O)[O-])cc1,CN(C)c1ccncc1,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20150225389A1,C[C@@H](N)c1ccc2c(c1)OC(F)(F)O2.O=C(Cl)Oc1ccccc1>>C[C@@H](NC(=O)Oc1ccccc1)c1ccc2c(c1)OC(F)(F)O2,,ClCCl,,CCN(CC)CC,Cl,val
US20060173041A1,NO.O=S(=O)(/C=C\CCCc1ncccn1)N1CCC(Oc2ccc(C(F)(F)F)cc2Cl)CC1>>O=S(=O)(CC(CCCc1ncccn1)NO)N1CCC(Oc2ccc(C(F)(F)F)cc2Cl)CC1,,C1CCOC1,,,,val
US20140309192A1,C1CNCCN1.O=[N+]([O-])c1cc(Cl)c(Cl)cc1F>>O=[N+]([O-])c1cc(Cl)c(Cl)cc1N1CCNCC1,,CC(C)O,,,,val
US20110250135A1,Brc1cnc(N2CCNCC2)nc1.Nc1ccc(OCc2ccccc2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(Nc1ccc(OCc2ccccc2)cc1)N1CCN(c2ncc(Br)cn2)CC1,,ClCCl,,Cl,,val
US20120059028A1,CCCI.CCc1ccc(-c2c(CC(=O)OC)c(C)nc3sc4c(c23)CCCC4)cc1>>CCCC(C(=O)OC)c1c(C)nc2sc3c(c2c1-c1ccc(CC)cc1)CCCC3,,CN(C)C=O,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20020188015A1,Cc1cc(C)c(S(=O)(=O)ON)c(C)c1.Nc1ncccn1>>Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1.NC1[NH+]=CC=CN1N,,ClCCl,,CCOCC,,val
US20150152118A1,CCOC(=O)C1=C(N)CCCC1.O=C(O)[C@@H]1CC[C@H](N2CCN(c3ccc(Cl)cc3)CC2)C1.c1ccncc1>>CCOC(=O)C1=C(NC(=O)[C@@H]2CC[C@H](N3CCN(c4ccc(Cl)cc4)CC3)C2)CCC2(CC2)C1,,ClC(Cl)Cl,,ClP(Cl)Cl,,val
US04226866,CC(=O)OCC(=O)CCl.CS(C)=O>>C=C(CCl)COC(C)=O,,CCCCCC,,[H-].[Na+],,val
US20160083400A1,CCOC(=O)c1noc(C2CCCC2)c1[N+](=O)[O-]>>CCOC(=O)c1noc(C2CCCC2)c1N,[Ni],CO,,,,val
US20140221333A1,CCN=C=O.Nc1nccn2c([C@@H]3CCCNC3)nc(-c3ccc(C(=O)Nc4ccccn4)cc3)c12>>CCNC(=O)N1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4ccccn4)cc3)c3c(N)nccn23)C1,,C1CCOC1,,,,val
US20160194284A1,CN(C(=O)Nc1cccc(-c2cccc(N3CCCC3)n2)c1)c1ccc(Cl)cc1.Cc1cc(Cl)ccc1O>>Cc1cc(Cl)ccc1OC(=O)Nc1cccc(-c2cccc(N3CCCC3)n2)c1,,ClCCl,,,,val
US03963675,C=C(C)C1CCC(C)=C1CCC=O.O=[Cr](=O)=O>>C=C(C)C1CCC(C)=C1CCC(=O)O,,CC(C)=O,,O=S(=O)(O)O,,val
US20100029633A1,CC(C)(C)OC(=O)N1CCOC(COS(C)(=O)=O)C1.COCCOc1ccn2c(-c3ccc4cccc(O)c4n3)cnc2c1>>COCCOc1ccn2c(-c3ccc4cccc(OCC5CN(C(=O)OC(C)(C)C)CCO5)c4n3)cnc2c1,,CC(=O)N(C)C,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20010039293A1,COC(=O)c1c(F)cc(N)cc1F.COCOc1cc2c(cc1C(=O)O)C(C)(C)CCC2(C)C>>COCOc1cc2c(cc1C(=O)Nc1cc(F)c(C(=O)OC)c(F)c1)C(C)(C)CCC2(C)C,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20030186984A1,CN(c1ncc(Br)cn1)[C@@H]1CC[C@@H](CCCOS(C)(=O)=O)CC1.CNC>>CN(C)CCC[C@@H]1CC[C@@H](N(C)c2ncc(Br)cn2)CC1,,CO,,,,val
US20150175599A1,O=S(Cl)Cl.OCc1ncc(Cl)cc1Cl>>ClCc1ncc(Cl)cc1Cl,,ClCCl,,,,val
US20090069296A1,CCOC(=O)C(F)(F)F.COc1cc2c(cc1OC)[C@@H](CN)C2>>COc1cc2c(cc1OC)[C@@H](CNC(=O)C(F)(F)F)C2,,CO,,CCN(CC)CC,,val
US20150087825A1,CC(CC1=CCCCC1)(N[S@](=O)C(C)(C)C)c1cc(Br)ccc1F>>CC(N)(CC1=CCCCC1)c1cc(Br)ccc1F,,CO,,Cl,,val
US20090088459A1,CCOC(=O)CN(Cc1ccccc1)S(=O)(=O)c1ccccc1C(F)(F)F.NN>>NNC(=O)CN(Cc1ccccc1)S(=O)(=O)c1ccccc1C(F)(F)F,,CCO,,O,,val
US20100190814A1,CCC(CC)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)Nc1cc(Cl)ccc12)C(=O)NS(C)(=O)=O.CCCCCCOC(=O)Cl>>CCCCCCOC(=O)N1C(=O)C2(c3ccc(Cl)cc31)C(c1cc(Cl)ccc1OC(CC)(CC)C(=O)NS(C)(=O)=O)CC(=O)NC2c1cc(F)ccc1C,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,,,val
US05681907,CCC(COCC1CO1)(COCC1CO1)COCC1CO1>>CCC(CO)(CO)CO,,CO,,,,val
US20100203007A1,COC(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)c4cc(NC(=O)OC(C)(C)C)cn4C)cn3C)cn2C)cn1C>>Cn1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)c4cc(NC(=O)OC(C)(C)C)cn4C)cn3C)cn2C)cc1C(=O)O,,CC(=O)N(C)C,O,[Li+].[OH-],,val
US05412144,CC(C)(C)OC(=O)C1=CCC(=C[C@H](C#N)CCCCCc2ccc(O)cc2)C=C1.COC(=O)Cl>>COC(=O)Oc1ccc(-c2ccc(C(=O)O)cc2)cc1,,CCO,O,Cl,[Na+].[OH-],val
US04369139,C=[N+]=[N-].O=C1CCCN1C(=O)c1ccc(O)cc1>>COc1ccc(C(=O)N2CCCC2=O)cc1,,C1CCOC1,,,,val
US20100009982A1,COC(=O)c1ccc(OCc2ccccc2)c(C(N)=O)c1>>COC(=O)c1ccc(O)c(C(N)=O)c1,[Pd],CO,,[H][H],,val
US20120022056A1,CC(=O)N(C)C.CC(=O)c1ncn2c1COc1c(CCN3CCC(c4cccc5nc(C)ccc45)CC3)cccc1-2>>C/C(=C/C(=O)c1ncn2c1COc1c(CCN3CCC(c4cccc5nc(C)ccc45)CC3)cccc1-2)N(C)C,,CC(=O)N(C)C,,,,val
US05145972,C1COCCN1.CC(C)=CC=O>>C=C(C)C=CN1CCOCC1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20080194616A1,BrBr.CCOC(=O)CC(=O)C(F)(F)F.Nc1ccccn1>>Br.O=c1c(Br)c(C(F)(F)F)nc2ccccn12,,CC(=O)O,,,,val
US20120301458A1,O=C(Cl)C(=O)Cl.O=C(O)/C=C/c1ccc(F)c(F)c1>>O=C(Cl)C=Cc1ccc(F)c(F)c1,,ClCCl,,CN(C)C=O,,val
US04086235,CCNCC.O=C(Cl)c1ccc([N+](=O)[O-])c([N+](=O)[O-])c1>>CCN(CC)C(=O)c1ccc([N+](=O)[O-])c([N+](=O)[O-])c1,,ClCCl,,,,val
US20100029619A1,CC1(C)OCC(CNC(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(Cl)ccc4n3)cc2)O1>>CC(C)(C(=O)NCC(O)CO)c1ccc(C(=O)Nc2cn3cc(Cl)ccc3n2)cc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20030212068A1,COCCN.Cc1ccc(NC(=O)c2ccc(C#N)cc2)cc1NC(=O)c1ccc(CCl)cc1>>COCCNCc1ccc(C(=O)Nc2cc(NC(=O)c3ccc(C#N)cc3)ccc2C)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20070155805A1,CCCC[Mg]Cl.CON(C)C(=O)c1cc2ccc(C(F)(F)F)cc2s1>>CCCCC(=O)c1cc2ccc(C(F)(F)F)cc2s1,,[Cl-],[NH4+],,,val
US07005440B1,CC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1O.CCOC(=O)COc1c(C)cccc1CBr>>CCOC(=O)COc1c(C)cccc1COc1cc(OCc2ccc3ccccc3n2)ccc1C(C)=O,,CC#N,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US06211234B1,N#Cc1ccc(O)cc1F.OCc1cnsc1>>N#Cc1ccc(OCc2cnsc2)cc1F,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080200523A1,CC(=O)Oc1ccc(CN2CCOCC2)cc1>>Oc1ccc(CN2CCOCC2)cc1,,CO,O,[Li]O,,val
US20110301161A1,COc1ccc(-n2cccn2)c(-c2nc3cc(-c4cnc(N)nc4)ccc3n2C(C)(C)C)c1>>CC(C)(C)n1c(-c2cc(O)ccc2-n2cccn2)nc2cc(-c3cnc(N)nc3)ccc21,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20020111358A1,Cc1ccc(S(=O)(=O)O)cc1.O=C1OCCC1=Cc1ccccc1OC[C@@H]1CO1.c1ccc2c(C3CCNCC3)cccc2c1>>Cc1ccc(S(=O)(=O)O)cc1.O=C1OCCC1=Cc1ccccc1OC[C@@H](O)CN1CCC(c2cccc3ccccc23)CC1,,CO,,CCOC(C)=O,,val
US20150225394A1,C=CCOC(=O)N(CC1CCNCC1)[C@@H]1C[C@H]1c1ccccc1.CC(C)(C)OC(=O)C=C1CN(C(=O)OC(C)(C)C)C1>>C=CCOC(=O)N(CC1CCN(C2(CC(=O)OC(C)(C)C)CN(C(=O)OC(C)(C)C)C2)CC1)[C@@H]1C[C@H]1c1ccccc1,,CC#N,ClCCl,C1CCC2=NCCCN2CC1,,val
US20090137580A1,CCOC(=O)Cc1ccc(Oc2ncnc3ccn(C)c23)cc1>>Cn1ccc2ncnc(Oc3ccc(CC(=O)O)cc3)c21,,CO,,Cl,[Na+].[OH-],val
US20130165412A1,CC(C)(C)[Si](C)(C)Cl.OC[C@H](O)c1ccncc1>>CC(C)(C)[Si](C)(C)OC[C@H](O)c1ccncc1,,CN(C)C=O,,O,c1c[nH]cn1,val
US05948932,CCC(=O)C(C)=NOC.CCCCON=O>>CON=C(C)C(=O)C(C)=NO,,CO,,Cl,C[O-].[Na+],val
US20050209336A1,CCCCC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc([C@H]2CCC(=O)[C@@H]2C(=O)O[C@@H]2[C@H](N(c3cc(C)cc(C)c3)S(=O)(=O)c3ccccc3)[C@H]3CC[C@]2(C)C3(C)C)cc1.CO>>CCCCC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc([C@H]2CCC(=O)[C@@H]2C(=O)OC)cc1,,CO,,,,val
US20080021043A1,CC(C)c1ccc(N)cc1.O=Cc1ccc(C(F)(F)F)cc1>>CC(C)c1ccc(/N=C/c2ccc(C(F)(F)F)cc2)cc1,,O,,ClCCl,,val
US20140275080A1,Clc1ccnc(Cl)c1.Nc1ccc(O)c(C(F)(F)F)n1>>Nc1ccc(Oc2ccnc(Cl)c2)c(C(F)(F)F)n1,,CC(=O)N(C)C,,CC(C)(C)[O-].[K+],,val
US20160031811A1,CC(=O)OCc1c2ccccc2c(COC(C)=O)c2ccccc12.CCCCCCC.CCOC(C)=O>>CCOC(=O)[C@@H](C)CCCc1ccccc1,,ClC(Cl)Cl,,,,val
US20090066231A1,CCN(CC)CC.N=C([O-])c1ccc(Br)cc1.O=C(Cl)c1ccc(Br)cc1>>CCO/C(=N\C(=O)c1ccc(Br)cc1)c1ccc(Br)cc1,,Cc1ccccc1,,,,val
US06239131B1,CCOC(=O)c1cccc(NC(=O)NC2CN(C3CCCCC3)c3ccc(C)cc3N(CC(=O)C(C)(C)C)C2=O)c1>>Cc1ccc2c(c1)N(CC(=O)C(C)(C)C)C(=O)C(NC(=O)Nc1cccc(C(=O)O)c1)CN2C1CCCCC1,,CO,,O,[Li+].[OH-],val
US20120016119A1,CC(C)OC(=O)N1CCC(n2cc(F)c3c(Nc4ccc(C(=O)N(C)C)cc4F)ncnc32)CC1.CCc1cnc(Cl)nc1>>CCc1cnc(N2CCC(n3cc(F)c4c(Nc5ccc(C(=O)N(C)C)cc5F)ncnc43)CC2)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20090118263A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.CNCCOc1cccc(CC(=O)OC)c1>>COC(=O)Cc1cccc(OCCN(C)C2CCN(C(=O)OC(C)(C)C)CC2)c1,,CC(=O)O,ClC(Cl)Cl,O=C([O-])O.[Na+],,val
US05221750,CC(C)(C)c1cc(O)no1.O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1>>CC(C)(C)c1cc(=O)n(-c2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090170920A1,CC(C)(C)OCCOc1ccc([C@@H](NC(=O)OC(C)(C)C)C(=O)O)cc1.C[C@@H](c1ccccc1)[C@H](N)c1nc(Cl)c(-c2ccc(I)cc2F)[nH]1>>C[C@@H](c1ccccc1)[C@H](NC(=O)[C@H](NC(=O)OC(C)(C)C)c1ccc(OCCOC(C)(C)C)cc1)c1nc(Cl)c(-c2ccc(I)cc2F)[nH]1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US20050130949A1,CCCCCCCCCCCC=CC(=O)OCC.NCCCNCCCCNCCCN>>CCCCCCCCCCCC(CC(=O)OCC)NCCCNCCCCNCCCN,,CCO,,,,val
US20130053375A1,CC(C)(C)OC(=O)N1CCC(S(=O)(=O)c2ccc3nccc(Nc4ccc5scnc5c4)c3c2)CC1>>O=S(=O)(c1ccc2nccc(Nc3ccc4scnc4c3)c2c1)C1CCNCC1,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US20090030082A1,BrCc1cccc(I)c1.COC(=O)Cc1cccc(OCCCNCC(c2ccccc2)c2ccccc2)c1>>COC(=O)Cc1cccc(OCCCN(Cc2cccc(I)c2)CC(c2ccccc2)c2ccccc2)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04053623,CN1CCN(C(=O)Oc2ccccc2)C1=C(C(=O)Oc1ccccc1)[N+](=O)[O-]>>CN1CCNC1=C(C(=O)Oc1ccccc1)[N+](=O)[O-],,CS(C)=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US04921852,CC(C)(C)[Si](C)(C)O[C@@H]1C[C@@H](C2=NCCN2C(=O)OCc2ccc([N+](=O)[O-])cc2)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1>>O=C(OCc1ccc([N+](=O)[O-])cc1)N1CCN=C1[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccc([N+](=O)[O-])cc1,,CO,,Cl,O=C([O-])O.[Na+],val
US05292739,Clc1cnn(CCCCBr)c1.c1ccc(N2CCNCC2)cc1>>Clc1cnn(CCCCN2CCN(c3ccccc3)CC2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100168161A1,COc1ccccc1C(F)(F)COc1ccc(CC#N)cc1>>COc1ccccc1C(F)(F)COc1ccc(CCN)cc1,O=[Pt]=O,C1CCOC1,CO,Cl,,val
US20090111809A1,CC(C)[Si](OC1CCN(N2CC[C@@H](Cc3c(Cl)cc(-c4ccc(S(C)(=O)=O)cc4)cc3Cl)C2=O)CC1)(C(C)C)C(C)C>>CS(=O)(=O)c1ccc(-c2cc(Cl)c(C[C@@H]3CCN(N4CCC(O)CC4)C3=O)c(Cl)c2)cc1,,C1CCOC1,CCOC(C)=O,O,O=C(O)C(F)(F)F,val
US20070060583A1,CC(C)(C)OC(=O)N1CCCC[C@@H]1CN.CCN(CC)C(=O)c1ccc(F)c([N+](=O)[O-])c1>>CCN(CC)C(=O)c1ccc(NC[C@H]2CCCCN2C(=O)OC(C)(C)C)c([N+](=O)[O-])c1,,CCO,,,,val
US20080009482A1,BrCCCCBr.COC(=O)CC#N>>COC(=O)C1(C#N)CCCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080027090A1,O=N[O-].c1ccc2c(c1)CCN2>>O=[N+]([O-])N1CCc2ccccc21,,CCOCC,O,Cl,,val
US05591762,CCCc1nc2c(C)cc(-c3cn(CC4CCCCC4)cn3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCc1nc2c(C)cc(-c3cn(CC4CCCCC4)cn3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US03988300,Clc1ccccc1.O=C(O)c1ccc([N+](=O)[O-])cc1Cl>>O=C(c1ccc(Cl)cc1)c1ccc([N+](=O)[O-])cc1Cl,,c1ccccc1,,,,val
US20160009744A1,Brc1csc(C2OCCO2)c1.O=C(CCCSC(c1ccccc1)(c1ccccc1)c1ccccc1)c1cccc(Cl)c1>>OC(CCCSC(c1ccccc1)(c1ccccc1)c1ccccc1)(c1cccc(Cl)c1)c1csc(C2OCCO2)c1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20060183745A1,CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4C#CC4CCCCN4CC(C)C)ncn3)cccc2s1>>CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4CCC4CCCCN4CC(C)C)ncn3)cccc2s1,,C1COCCO1,,Cl,,val
US20030018067A1,CCCCC(=O)c1c(-c2ccc3cc(OCC(=O)OCC)ccc3c2)oc2ccccc12>>CCCCC(=O)c1c(-c2ccc3cc(OCC(=O)O)ccc3c2)oc2ccccc12,,CCO,O,[Na+].[OH-],,val
US20130129753A1,CC(C)(CNC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC)OC)N(C)C(=O)[C@@H](N)C(C)C>>CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC)OC)N(C)C(=O)[C@@H](NC(=O)C(C)(C)CNC(=O)OCC1c2ccccc2-c2ccccc21)C(C)C,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150231143A1,CCN(CC)CC.CN(C)C=O.CN(C)c1c(-c2ccc(Cl)cc2)sc(C(=O)O)c1-c1ccc(S(N)(=O)=O)cc1.ClCCl>>CON(C)C(=O)c1sc(-c2ccc(Cl)cc2)c(N(C)C)c1-c1ccc(S(=O)(=O)N=CN(C)C)cc1,,ClCCl,ClCCl,O=C(Cl)C(=O)Cl,,val
US20050176721A1,COc1cc(OC(F)(F)F)ccc1-c1nc(OC)c([N+](=O)[O-])cc1C>>COc1cc(OC(F)(F)F)ccc1-c1nc(OC)c(N)cc1C,[Pd],CO,,,,val
US20110313002A1,COC(=O)[C@H](CC1CCCCC1)N1CC2=Cc3c(OC)cccc3OC2C1=O>>COc1cccc2c1CC1=C(O2)C(=O)N([C@@H](CC2CCCCC2)C(=O)O)C1,,C1CCOC1,O,[Li+].[OH-],,val
US05476944,CC(C)(C)c1cc(S[C@@H]2CCCC[C@H]2O)cc(C(C)(C)C)c1.CC(C)(C)c1cc(S[C@@H]2CCC[C@H]2O)cc(C(C)(C)C)c1.CC(C)(C)c1ccc(S[C@H]2CCC[C@H]2O)c(C(C)(C)C)c1.ClC(Cl)Cl>>CC(C)(C)c1cc(S[C@@H]2CCCC[C@H]2OCC(=O)O)cc(C(C)(C)C)c1,,ClC(Cl)Cl,,,,val
US20130331375A1,CCn1ccc2c(=O)[nH]c(Cl)cc21.Fc1ccccc1N1CCNCC1>>CCn1ccc2c(=O)[nH]c(N3CCN(c4ccccc4F)CC3)cc21,,CO,ClCCl,,,val
US20090298836A1,CC(C)(C)OC(=O)N(C[C@@H](N)Cc1ccc(C(F)(F)F)cc1)c1nnc(-c2ccc3ncncc3c2)s1>>N[C@H](CNc1nnc(-c2ccc3ncncc3c2)s1)Cc1ccc(C(F)(F)F)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060211739A1,C[Si](C)(C)N=[N+]=[N-].N#Cc1cccc(Cl)c1Cl>>Clc1cccc(-c2nnn[nH]2)c1Cl,,Cc1ccccc1,,C[Al](C)C,Cl,val
US05739338,CC(C)=CC(=O)Cl.COc1cccc(Nc2ccc(C)cc2)c1>>COc1cccc(N(C(=O)C=C(C)C)c2ccc(C)cc2)c1,,C1CCOC1,,CCN(CC)CC,O,val
US20100331293A1,COc1ncccc1B(O)O.Cc1c(Cl)nc2cc(F)cc(F)c2c1Cl>>COc1ncccc1-c1nc2cc(F)cc(F)c2c(Cl)c1C,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20160024093A1,CC(C)OC(=O)Cl.CC1CN(C(=O)OC(C)(C)C)CCN1>>CC(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)CC1C,,CCOC(C)=O,Cc1ccccc1,CCN(C(C)C)C(C)C,,val
US20110230555A1,COCCCCCCCCCCCCN.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COCCCCCCCCCCCCN=C=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040043987A1,Brc1ccccn1.O=S1(=O)NC(C2CCCCC2)=Nc2c(Cl)ccc(B(O)O)c21>>O=S1(=O)NC(C2CCCCC2)=Nc2c(Cl)ccc(-c3ccccn3)c21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20110054017A1,C[C@H](CCCCC(=O)OC(C)(C)C)N=[N+]=[N-]>>C[C@@H](N)CCCCC(=O)OC(C)(C)C,[Pd],C1CCOC1,,,,val
US20020188000A1,CCN(CC)S(F)(F)F.N#Cc1ccccc1-c1cccc(-c2cnc3cc(CO)ccn23)c1>>N#Cc1ccccc1-c1cccc(-c2cnc3cc(CF)ccn23)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US06255333B1,ClC(Cl)(Cl)Cl.N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)cc1C=O>>N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)cc1C=C(Cl)Cl,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050080097A1,CC(C)c1n[nH]c2c(NCc3ccccc3)nc(Cl)nc12.NCCN>>CC(C)c1n[nH]c2c(NCc3ccccc3)nc(NCCN)nc12,,CN1CCCC1=O,,,,val
US20040157881A1,O=C(Cl)c1ccccc1[N+](=O)[O-].c1cc(C2OCCO2)ccc1-c1nnn[nH]1>>O=[N+]([O-])c1ccccc1-c1nnc(-c2ccc(C3OCCO3)cc2)o1,,O,,c1ccncc1,,val
US20060089347A1,CC(C)=O.Cl.Cl.c1cc2c(cc1OCCN1CCCCC1)CCCNC2>>CC(C)N1CCCc2cc(OCCN3CCCCC3)ccc2C1.Cl.Cl,CC(=O)O,CO,ClCCCl,[BH3-]C#N.[Na+],,val
US04152441,COCn1ccnc1.O=C(c1ccc(C(F)(F)F)cc1)c1ccc(C(F)(F)F)cc1>>COCn1ccnc1C(O)(c1ccc(C(F)(F)F)cc1)c1ccc(C(F)(F)F)cc1,,C1CCOC1,O,CN(C)CCN(C)C,[Li]CCCC,val
US20040186160A1,CN(C)CCCc1c(C=O)[nH]c2c1CCCCC2.O=C1Cc2cc(S(=O)(=O)Cc3ccccc3)ccc2N1>>CN(C)CCCc1c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4ccccc4)cc32)[nH]c2c1CCCCC2,,CCO,,C1CCNCC1,,val
US20150197538A1,CC(=O)OC[C@H]1O[C@H](n2cc(-c3ccccc3)nn2)[C@@H](CC(=O)[O-])[C@H](OC(C)=O)[C@H]1OC(C)=O.CN.COC(=O)c1cc(Br)cc(C(=O)OC)c1>>CN(C)C(=O)c1cc(Br)cc(C(N)=O)c1,,CCO,,,,val
US05037825,CC(=O)c1ccc2c(c1)CCCCO2>>CC(O)c1ccc2c(c1)CCCCO2,,CO,,[BH4-].[Na+],,val
US20020128277A1,C1CCNC1.NCc1ccc(C(F)(F)F)cc1.O=C(Cl)c1cnc(Cl)nc1C(F)(F)F>>O=C(NCc1ccc(C(F)(F)F)cc1)c1cnc(N2CCCC2)nc1C(F)(F)F,,ClCCl,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US05277838,COc1ccc(O)cc1.C[SiH](C)c1ccc(C(=O)Cl)cc1>>COc1ccc(OC(=O)c2ccc([SiH](C)C)cc2)cc1,,Cc1ccccc1,,,,val
US05651919,CC(=O)Cl.Fc1ccc(-c2ccccc2)cc1F>>CC(=O)C1(F)C=CC(c2ccccc2)=CC1F,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20020025959A1,CCOC(=O)C(C(=O)OCC)C(OCC)C1CCCc2cc(CN3CCOCC3)cnc21>>CCOC(=O)c1cc2c3c(cc(CN4CCOCC4)cn3c1=O)CCC2,,CCN(CC)CC,,CCO,,val
US20100240702A1,Cn1ccc2cc(Br)cc(CO)c21>>Cn1ccc2cc(Br)cc(C=O)c21,O=[Mn]=O,CC(C)=O,,,,val
US20100216761A1,C=CC[C@@H](N[S@@](=O)C(C)(C)C)c1ccc(OC(F)(F)F)cc1.Cl>>C=CC[C@@H](N)c1ccc(OC(F)(F)F)cc1.Cl,,CCOCC,,,,val
US20070032478A1,CN1CCN(c2ccc(N)cc2)CC1.Cc1nn(C)c(Cl)c1C(=O)Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3=CO)c1>>Cc1nn(C)c(Cl)c1C(=O)Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3=CNc2ccc(N3CCN(C)CC3)cc2)c1,,C1CCOC1,,,,val
US20110065681A1,Cc1ccc(B2OC(C)(C)C(C)(C)O2)c(C#N)c1.Cc1ncc(CNC(=O)c2cc(Br)cc(C(=O)N3CCCC3)c2)cn1>>Cc1ccc(-c2cc(C(=O)NCc3cnc(C)nc3)cc(C(=O)N3CCCC3)c2)c(C#N)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[Cs+].[Cs+],val
US06045974,C1CCOC1.CCCCC.Cc1ccc2ccccc2c1Br.FB(F)c1ccccc1.[Li]C(C)(C)C>>Cc1ccc2ccccc2c1B(c1ccccc1)c1c(C)ccc2ccccc12,,C1CCOC1,CCCCC,O,,val
US20140187545A1,CCOC(CC#N)OCC.Cc1cccc(C=O)c1C>>COC(OC)/C(C#N)=C/c1cccc(C)c1C,,CO,,C[O-].[Na+],,val
US20090264469A1,CCCCCCCCOc1c(Br)cc(C=O)cc1OC>>CCCCCCCCOc1c(Br)cc(CO)cc1OC,,C1CCOC1,,[BH4-].[Na+],,val
US20100029650A1,CC(C)OB(OC(C)C)OC(C)C.COCCNS(=O)(=O)c1ccc(Br)cc1>>COCCNS(=O)(=O)c1ccc(B(O)O)cc1,,C1CCOC1,,[Li]CCCC,,val
US20100331293A1,Cc1c(-c2ccccc2F)nc2cccc(F)c2c1Cl.Nc1cc(N2CCOCC2)ccc1N1CCOCC1>>Cc1c(-c2ccccc2F)nc2cccc(F)c2c1Nc1cc(N2CCOCC2)ccc1N1CCOCC1,,CO,,C1COCCO1,Cl,val
US05106998,CC(=O)c1c(O)ccc2ccccc12.O=C1C2CCCC1CCC2>>OC1CCc2ccccc2O1,,Cc1ccccc1,,C1COCCN1,,val
US20120165310A1,O=C1CCC(=O)N1Br.O=S1(=O)CCN(C[C@@H]2C[C@H](n3ccc4c(Cl)ncnc43)C2)CC1>>O=S1(=O)CCN(C[C@@H]2C[C@H](n3cc(Br)c4c(Cl)ncnc43)C2)CC1,,CN(C)C=O,ClCCl,,,val
US20130072467A1,OCC1CN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)C1>>O=CC1CN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)C1,,CS(C)=O,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20070060567A1,COC(=O)c1ccc2c(c1)N(S(=O)(=O)c1cc(Cl)ccc1OC)CC2>>COc1ccc(Cl)cc1S(=O)(=O)N1CCc2ccc(C(=O)O)cc21,,C1CCOC1,CO,[K+].[OH-],,val
US20100197693A1,O=C(Cl)C(=O)Cl.O=C(O)c1cc(S(=O)(=O)Cl)c(F)cc1Cl>>O=C(Cl)c1cc(S(=O)(=O)Cl)c(F)cc1Cl,,CN(C)C=O,,ClCCl,,val
US20110301310A1,Cc1cc(C)c(NCc2ccc3ccccc3c2-c2cccc(C=Nc3c(C(C)C)cccc3C(C)C)n2)c(C)c1.[Li]c1ccccc1C(C)C>>Cc1cc(C)c(NCc2ccc3ccccc3c2-c2cccc(C(Nc3c(C(C)C)cccc3C(C)C)c3ccccc3C(C)C)n2)c(C)c1,,O,,CCOCC,,val
US20070225267A1,CC(=O)Oc1cccc(C[C@@H]([C@H](O)[C@H]2COC(C)(C)N2C(=O)OC(C)(C)C)[N+](=O)[O-])c1>>CC(C)(C)OC(=O)N1[C@@H]([C@@H](O)[C@@H](N)Cc2cccc(O)c2)COC1(C)C,Cl[Ni]Cl,CO,,[BH4-].[Na+],,val
US20110275797A1,CC(C)(C)OC(=O)c1ccc(-c2ccccc2)cc1NC(=O)c1cc(CCBr)ccc1OCc1ccccc1.CN1CCNCC1>>CN1CCN(CCc2ccc(OCc3ccccc3)c(C(=O)Nc3cc(-c4ccccc4)ccc3C(=O)OC(C)(C)C)c2)CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150266881A1,COC(=O)[C@@H]1C[C@H]1c1ccc(F)cc1Br>>O=C(O)[C@@H]1C[C@H]1c1ccc(F)cc1Br,,C1CCOC1,CO,O,[Na+].[OH-],val
US05677306,O=C1CCc2ccc(Cl)c(Cl)c21.O=C1c2cccc(F)c2CC1Br>>O=C1c2c(ccc(Cl)c2Cl)CC1Br,Br[Cu]Br,C1COCCO1,,,,val
US20030186976A1,COC(=O)CBr.O=Cc1ccc(N2CCOCC2)cc1O>>COC(=O)c1cc2ccc(N3CCOCC3)cc2o1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120129840A1,CCOC(=O)c1c(C)nc(N2CCCCC2)nc1-c1ccc(C)cc1>>Cc1ccc(-c2nc(N3CCCCC3)nc(C)c2CO)cc1,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US04472412,C1CCNC1.CCCCCC(=Cc1ccc(Cl)cc1Cl)CBr>>CCCCCC(=Cc1ccc(Cl)cc1Cl)CN1CCCC1,,ClC(Cl)Cl,,,,val
US20110190336A1,CC(C)(C)OC(=O)N1CCC(Nc2ncccc2[N+](=O)[O-])CC1>>CC(C)(C)OC(=O)N1CCC(Nc2ncccc2N)CC1,[Pd],CO,,,,val
US20150361069A1,Cc1[nH]nc(Nc2ncnc3cc(Cl)c(S(=O)(=O)C(C)(C)C)cc23)c1C.OCC1CCCO1>>Cc1[nH]nc(Nc2ncnc3cc(OCC4CCCO4)c(S(=O)(=O)C(C)(C)C)cc23)c1C,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20130005750A1,C1CCOC1.[N-]=[N+]=NCc1cc(Oc2ccc3c(ccn3C(=O)Nc3cccc(C(F)(F)F)c3)c2)ccn1>>NCc1cc(Oc2ccc3c(ccn3C(=O)Nc3cccc(C(F)(F)F)c3)c2)ccn1.[NH4+].[OH-],,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070208054A1,CCOC(=O)C[C@H](NC(=O)OCc1ccccc1)c1cccc(NC(=O)OCCc2ccc(C(Nc3ccc4c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cccc4c3)C(=O)O)cc2C)c1>>CCOC(=O)C[C@H](N)c1cccc(NC(=O)OCCc2ccc(C(Nc3ccc4c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cccc4c3)C(=O)O)cc2C)c1,[Pd],CO,Cl,,,val
US20070129414A1,CCO.Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O.Cl.O>>Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O.Cl.O.O,,CCO,O,,,val
US20090298807A1,CC(C)(C)OC(=O)N1CCC2(CC1)CNCC(F)(F)O2.CC(C)c1nc(C(=O)O)cs1>>CC(C)c1nc(C(=O)N2CC(F)(F)OC3(CCN(C(=O)OC(C)(C)C)CC3)C2)cs1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160244441A1,FCCBr.Oc1ccc(-c2cn3ccc(N4CCC4)cc3n2)cc1>>FCCOc1ccc(-c2cn3ccc(N4CCC4)cc3n2)cc1,,ClCCl,O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20030092910A1,COc1cc(OC)cc(N2CCNCC2)c1.COc1nc(C)c(C)nc1NC(=S)Oc1ccccc1>>COc1cc(OC)cc(N2CCN(C(=S)Nc3nc(C)c(C)nc3OC)CC2)c1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20150087646A1,C#CC1CC1.CC(C)(C)C(=O)NCc1cc(-n2nc(-c3ccc(I)cc3)[nH]c2=O)c(Cl)cc1Cl>>CC(C)(C)C(=O)NCc1cc(-n2nc(-c3ccc(C#CC4CC4)cc3)[nH]c2=O)c(Cl)cc1Cl,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CS(C)=O,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090291955A1,CC(=O)Cl.NC(=O)c1sc(N2CCC(Oc3ccccc3C(F)(F)F)CC2)nc1N>>Cc1nc2nc(N3CCC(Oc4ccccc4C(F)(F)F)CC3)sc2c(=O)[nH]1,,CC(=O)O,,,,val
US05250679,CC=CN.c1ccc(CC2CO2)cc1>>C=CCNCC(O)Cc1ccccc1,,CO,,,,val
US20070191342A1,CCOC(=O)N1CCc2scc(Br)c2C(C)C1.C[Zn]C>>CCOC(=O)N1CCc2scc(C)c2C(C)C1,,C1COCCO1,,,,val
US20150315188A1,Cc1ccc2c(c1)c1c(n2CC(O)c2ccc(C(=O)O)nc2)CCN(C)C1.NC1CC1>>Cc1ccc2c(c1)c1c(n2CC(O)c2ccc(C(=O)NC3CC3)nc2)CCN(C)C1,,ClCCl,O,CCN=C=NCCCN(C)C,Cl,val
US20160039809A1,CC1Cc2c(nnn2-c2ccnn2Cc2ccccc2)CN1>>CC1Cc2c(nnn2-c2ccn[nH]2)CN1,Cl[Pd]Cl,,,CO,Cl,val
US20140128372A1,CC(C#N)(NC(CO)c1ccccc1)C(F)(F)F>>CC(CN)(NC(CO)c1ccccc1)C(F)(F)F,,COC(C)(C)C,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130065906A1,Fc1cnccn1.O=C(c1ccc(-c2cnco2)cc1)N(C1CCNCC1)C1CC1>>O=C(c1ccc(-c2cnco2)cc1)N(C1CC1)C1CCN(c2cnccn2)CC1,,CN1CCCC1=O,,Cl,,val
US05344843,COC(=O)C(=O)c1ccc(O)cc1.ClCC#Cc1ccccc1>>COC(=O)C(=O)c1ccc(OCC#Cc2ccccc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20090036443A1,CCOC(=O)c1cc(NC(=O)OC(C)(C)C)cs1.O=C1CCC(=O)N1Br>>CCOC(=O)c1cc(NC(=O)OC(C)(C)C)c(Br)s1,,ClCCl,,,,val
US20140275011A1,Brc1ccc2[nH]ccc2c1.O=C(Cl)c1cccc(F)c1>>O=C(c1cccc(F)c1)c1c[nH]c2ccc(Br)cc12,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20160240783A1,CC1(C)C=C(Br)C=C2C=c3cc4c5ccccc5c5ccccc5c4cc3=C21.CC1(C)OB(c2ccc(N(c3ccc(-c4ccccc4)cc3)c3ccc4c(c3)C3(c5ccccc5-c5ccccc53)c3ccccc3-4)cc2)OC1(C)C>>CC1(C)C=C(c2ccc(N(c3ccc(-c4ccccc4)cc3)c3ccc4c(c3)C3(c5ccccc5-c5ccccc53)c3ccccc3-4)cc2)C=C2C=c3cc4c5ccccc5c5ccccc5c4cc3=C21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US05057524,NC(=O)CCCCl.O=C(O)C(=O)O.OC(c1ccc(F)cc1)(c1ccc(F)cc1)C1CCNCC1>>NC(=O)CCCN1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1.O=C(O)C(=O)O,,CN(C)C=O,O,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US05284847,CCOC(=O)C(=O)Nc1sc(-c2ccccc2)cc1[N+](=O)[O-]>>O=c1[nH]c2cc(-c3ccccc3)sc2[nH]c1=O,[Zn],CC(=O)O,,O,,val
US20150175602A1,CC(=O)OC(C)=O.CC(C)Nc1nc2c(nc1N1CCC(C(=O)c3cc(Cl)ccc3F)CC1)CCNC2.O=C(O)C(F)(F)F>>CC(=O)N1CCc2nc(N3CCC(C(=O)c4cc(Cl)ccc4F)CC3)c(NC(C)C)nc2C1.O=C(O)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US20030004181A1,CCOC(=O)CN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C)c1ccccn1.COC(=O)Cl>>CCOC(=O)CN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)NC(=O)OC)cc1)n2C)c1ccccn1,,CCO,ClCCl,Cl,,val
US20070208056A1,CC(C)[C@@H](N)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1.CN=C=O>>CNC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C,,CCN(CC)CC,,C1CCOC1,Cl,val
US06274286B1,C1CCOC1.CO.COCCOCCl.COCCOCOCCl.OCCN(CCO)CCO>>COCCOCOCCN(CCOCOCCOC)CCOCOCCOC,,CO,,CC(C)(C)[O-].[K+],,val
US20090270460A1,CC(C)c1cnn(-c2c(Cl)cccc2Cl)c1CBr.CCCCOc1cc(-c2ccc(O)cc2C)ccc1C=O>>CCCCOc1cc(-c2ccc(OCc3c(C(C)C)cnn3-c3c(Cl)cccc3Cl)cc2C)ccc1C=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150065482A1,CN.NC(=O)c1nn(-c2cc(I)ccn2)c2ccc(CCl)cc12>>CNCc1ccc2c(c1)c(C(N)=O)nn2-c1cc(I)ccn1,,ClCCl,,CCN(CC)CC,,val
US20100286112A1,CC(C)(C)OC(=O)NC(Cc1ccc(O)cc1F)C(=O)O.CO>>COC(=O)C(Cc1ccc(O)cc1F)NC(=O)OC(C)(C)C,,CO,Cc1ccccc1,C[Si](C)(C)C=[N+]=[N-],,val
US20150274673A1,Cc1ccc(F)c(O)c1.O=C1CCO1>>Cc1ccc(F)c(OCCC(=O)O)c1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US03933890,C=[N+]=[N-].CCCCCC(O)CCC1C(CCCCCCC(=O)O)CC(O)C1O>>CCCCCC(O)CCC1C(CCCCCCC(=O)OC)CC(O)C1O,,CCOCC,,,,val
US20040132727A1,COc1cc2nccc(Oc3ccc(NC(=O)COc4c(C)cccc4C)cc3C)c2cc1OC>>COc1cc2nccc(Oc3ccc(NCCOc4c(C)cccc4C)cc3C)c2cc1OC,,C1CCOC1,,Cl,[Na+].[OH-],val
US20090233359A1,CCOC(=O)C(F)(F)F.NCCO>>O=C(NCCO)C(F)(F)F,,CO,,CCN(CC)CC,,val
US20020042427A1,CNS(=O)(=O)c1ccc2c(c1)CC(=O)N2.O=Cc1[nH]cc2c1CCNC2=O>>CNS(=O)(=O)c1ccc2c(c1)C(=Cc1[nH]cc3c1CCNC3=O)C(=O)N2,,CCO,,C1CCNCC1,,val
US04205080,CCOC(=O)c1cc2cc(-c3ccc(C(C)O)cc3)ccc2o1>>CC(O)c1ccc(-c2ccc3c(c2)CC(C(=O)O)O3)cc1,,C1CCOC1,,CCO,,val
US20100145047A1,CC1(C)CC(=O)OC1=O.O=C(Nc1ccc(N2CCNCC2)nc1)c1cc2c(Cl)cccc2s1>>CC(C)(CC(=O)N1CCN(c2ccc(NC(=O)c3cc4c(Cl)cccc4s3)cn2)CC1)C(=O)O,,ClCCl,,,,val
US20060211720A1,CCc1cccc(Br)c1.O=Cc1nc(Br)cn1C(c1ccccc1)(c1ccccc1)c1ccccc1>>CCc1cccc(C(O)c2nc(Br)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1,,C1CCOC1,,[Li]CCCC,,val
US20040082611A1,CCC1CNCCN1.O=S(=O)(Cl)c1cc2ccc(Cl)cc2s1>>CCC1CN(S(=O)(=O)c2cc3ccc(Cl)cc3s2)CCN1,,ClCCl,O,CCN(CC)CC,Cl,val
US20010049441A1,CN1CC=C(c2c[nH]c3ncccc23)CC1.O=S(=O)(Cl)c1ccccc1>>CN1CC=C(c2cn(S(=O)(=O)c3ccccc3)c3ncccc23)CC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20060287363A1,C[C@@H]1CC(=O)CCN1C(=O)OC(C)(C)C.Nc1cccc(NC(=O)c2ccc(F)cc2Cl)c1>>C[C@@H]1C[C@H](Nc2cccc(NC(=O)c3ccc(F)cc3Cl)c2)CCN1C(=O)OC(C)(C)C,,C1CCOC1,CO,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120035168A1,CCOC(=O)c1cnn(Cc2ccc3c(c2)cc(C)n3C)c1>>Cc1cc2cc(Cn3cc(C(=O)O)cn3)ccc2n1C,,C1COCCO1,,Cl,[Na+].[OH-],val
US06610707B1,CCOC(=N)[C@@H]1CCCCN1S(=O)(=O)c1ccc(F)cc1.NNC=O>>O=S(=O)(c1ccc(F)cc1)N1CCCC[C@H]1c1nc[nH]n1,,C1COCCO1,Cc1ccccc1,,,val
US20100075952A1,Cc1c(C=O)[nH]c2c1C(=O)N(CC(O)CN1CCOCC1)CCC2.O=C1Cc2c(ccc(F)c2-c2cccc(F)c2F)N1>>Cc1c(/C=C2\C(=O)Nc3ccc(F)c(-c4cccc(F)c4F)c32)[nH]c2c1C(=O)N(C[C@H](O)CN1CCOCC1)CCC2,,CCO,,C1CCNCC1,,val
US04239897,COC(=O)C1=CSCC1O>>COC(=O)c1cscc1O,,ClC(Cl)(Cl)Cl,,O=C1CCC(=O)N1Br,,val
US20090274713A1,COC(=O)C(CCN=[N+]=[N-])S(=O)(=O)O>>[N-]=[N+]=NCCC(C(=O)O)S(=O)(=O)O,,Cl,,,,val
US04381303,Cn1ncc(N)c1C(=O)Nc1cccnc1Cl>>Cn1ncc2c1C(=O)Nc1cccnc1N2,O=S(=O)(O)O,O=S1(=O)CCCC1,,,,val
US20040067984A1,OC1(c2ccccc2)CCCCC1>>C1=C(c2ccccc2)CCCC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100093711A1,O=C1CCN(C(=O)c2ccccc2)c2ccccc21>>O=C(c1ccccc1)N1CCC(O)c2ccccc21,,CO,,[BH4-].[Na+],,val
US20070197604A1,Cc1oc(-c2ccc(OCc3ccccc3)cc2)nc1CC(=O)N1CCC[C@H]1C>>Cc1oc(-c2ccc(OCc3ccccc3)cc2)nc1CCN1CCC[C@H]1C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04569802,O=C(NCO)C(F)(F)F.O=S(Cl)Cl>>O=C(NCCl)C(F)(F)F,,ClCCl,,,,val
US20010051623A1,CCCCOc1ccc(C(=O)Cl)cc1.CN1CCN(c2ccc(O)c3c2C[C@H](N)CC3)CC1>>CCCCOc1ccc(C(=O)N[C@@H]2CCc3c(O)ccc(N4CCN(C)CC4)c3C2)cc1,,CN(C)C=O,,CCN(CC)CC,,val
US05232929,CCI.COc1ccccc1CN(C(=O)OC(C)(C)C)[C@@H]1CCC(=O)N[C@@H]1c1ccccc1>>CCN1C(=O)CC[C@@H](NCc2ccccc2OC)[C@H]1c1ccccc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US05627200,CCc1c(C(=O)O)oc2ccc(OC)cc12>>O=C(O)c1cc2cc(O)ccc2o1,,ClCCl,,BrB(Br)Br,,val
US04493840,CN(C)Cc1ccc(CSCCN)o1.CSC(=NC#N)NCCSCc1csc(NC(=N)N)n1>>CN(C)Cc1ccc(CSCCNC(=NC#N)NCCSCc2csc(NC(=N)N)n2)o1,,CC#N,,,,val
US20030166644A1,COc1ccc(O)cn1.Clc1cnc(Cl)c(Cl)c1>>COc1ccc(Oc2ncc(Cl)cc2Cl)cn1,,CS(C)=O,,O,[K+].[OH-],val
US20080287396A1,BrCc1ccccc1.CCOP(=O)(CP(=O)(OCC)c1ccc(O)c(C(C)(C)CC(=O)O)c1)OCC>>CCOP(=O)(CP(=O)(OCC)c1ccc(O)c(C(C)(C)CC(=O)OCc2ccccc2)c1)OCC,,CC#N,,[K+].[OH-],,val
US20100113504A1,C=CCCCOc1ccncc1NC(=O)C(CCCCCC(=O)OC)OCC=C>>COC(=O)CCCCCC1OCCCCCCOc2ccncc2NC1=O,,CCOC(C)=O,,CO,,val
US05030746,C#CC(C)(C)N.C[Si](C)(C)Cl>>C#CC(C)(C)N[Si](C)(C)C,,C1CCOC1,,CCN(CC)CC,,val
US20160200709A1,CC(C)(C)OC(=O)/N=C(\NC(=O)OC(C)(C)C)n1cccn1.N[C@H](Cc1ccccc1)c1cc2cc(Cl)cc(NCc3ccccc3)c2[nH]1>>CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)N[C@H](Cc1ccccc1)c1cc2cc(Cl)cc(NCc3ccccc3)c2[nH]1,,CC#N,,CCN(CC)CC,,val
US20120245124A1,O=Cc1cccc(Br)n1.OB(O)c1ccc(F)c(Cl)c1>>O=Cc1cccc(-c2ccc(F)c(Cl)c2)n1,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120238574A1,Nc1ccc2ncn(C3CCN(Cc4ccc(C(O)(C(F)(F)F)C(F)(F)F)cc4)CC3)c2c1.O=C(Nc1ccncc1)Oc1ccccc1>>O=C(Nc1ccncc1)Nc1ccc2ncn(C3CCN(Cc4ccc(C(O)(C(F)(F)F)C(F)(F)F)cc4)CC3)c2c1,,C1COCCO1,,,,val
US20150246930A1,O=C(Cl)OCc1ccccc1.O=C(c1cccc(Cl)c1)c1cccc2c1NCCN2>>O=C(c1cccc(Cl)c1)c1cccc2c1NCCN2C(=O)OCc1ccccc1,,ClCCl,,c1ccncc1,,val
US20070265270A1,Brc1ccc2cn[nH]c2c1.COc1cc2nncc(-c3nc4ccccc4o3)c2cc1OC>>COc1cc2nncc(-n3ncc4ccc(Br)cc43)c2cc1OC,[Cu]I,Cc1ccccc1,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US06265409B1,CC(C)(C)[Si](C)(C)O[C@H](CCc1cccnc1)COc1ccc(Br)cc1.CC(C)OB(OC(C)C)OC(C)C>>CC(C)(C)[Si](C)(C)O[C@H](CCc1cccnc1)COc1ccc(B(O)O)cc1,,C1CCOC1,CCOC(C)=O,O,[Li]CCCC,val
US04777252,CCOC(=O)c1c[nH]c2cc(OC)c(OC)cc2c1=O>>COc1cc2[nH]cc(C(=O)O)c(=O)c2cc1OC,,[Na+],[OH-],Cl,,val
US20080009530A1,CCCCCS(=O)(=O)NC(=O)/C=C/c1ccc(OCCOCCOC)cc1Oc1ncc(C(F)(F)F)cc1Cl>>CCCCCS(=O)(=O)NC(=O)CCc1ccc(OCCOCCOC)cc1Oc1ncc(C(F)(F)F)cc1Cl,,C1CCOC1,CO,,,val
US20030225122A1,CC(Br)C(N)=O.Fc1cccc(COc2ccc3c(c2)CCNC3)c1>>CC(C(N)=O)N1CCc2cc(OCc3cccc(F)c3)ccc2C1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050054681A1,NCCCOc1cc(=O)oc2ccc(Cl)cc12.O=C(Cl)c1ccncc1.O=C(O)C(F)(F)F>>O=C(NCCCOc1cc(=O)oc2ccc(Cl)cc12)c1ccncc1.O=C(O)C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20120184520A1,CN(Cc1cccc(-c2cnc(N3CCNCC3)nc2)c1)C(=O)CNC(=O)OC(C)(C)C.O=C1CCC(=O)O1>>CN(Cc1cccc(-c2cnc(N3CCN(C(=O)CCC(=O)O)CC3)nc2)c1)C(=O)CNC(=O)OC(C)(C)C,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US04269788,CCNCC.CS(=O)(=O)OCCC1(c2ccccc2)C=CCC=C1>>CCN(CC)CCC1(c2ccccc2)C=CCC=C1,,Cc1ccccc1,,,,val
US04914092,CN(CCO)CC(=O)N1CCc2ccccc2C1.O=S(Cl)Cl>>CN(CCCl)CC(=O)N1CCc2ccccc2C1,,ClC(Cl)Cl,,,,val
US20100190967A1,CC(C)(C)OC(=O)CN1CCNCCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1.CC(C)(C)c1ccc(CNC(=O)CCl)cc1>>CC(C)(C)OC(=O)CN1CCN(CC(=O)NCc2ccc(C(C)(C)C)cc2)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090111805A1,Clc1ncnc2[nH]cc(Br)c12.O=Cc1ccccc1>>OC(c1ccccc1)c1c[nH]c2ncnc(Cl)c12,,C1CCOC1,,[Li]CCCC,,val
US20160250211A1,Clc1ccnc(Cl)n1.Nc1cc(-c2ccco2)[nH]n1>>Clc1nccc(Nc2cc(-c3ccco3)[nH]n2)n1,,C1CCOC1,O,CC(=O)[O-].[K+],,val
US04680301,C1CSCCN1.CC(C)(C)c1nc2cc(Cl)c([N+](=O)[O-])cc2s1>>CC(C)(C)c1nc2cc(N3CCSCC3)c([N+](=O)[O-])cc2s1,,CN1CCCC1=O,,O,O=C([O-])[O-].[K+].[K+],val
US04357352,ClP(Cl)(Cl)(Cl)Cl.N#CC1CC2C3CC4C2C4C13>>N#CC1(Cl)CC2C3CC4C2C4C31,,ClC(Cl)(Cl)Cl,,O,,val
US20080114006A1,CCOC(=O)Cc1cc([N+](=O)[O-])ccc1Cl>>CCOC(=O)Cc1cc(N)ccc1Cl,[Fe],CCO,,Cl,,val
US20120101134A1,COC(=O)[C@H](C)Cc1cccc(-c2noc(-c3cnc(OC(C)C)c(Cl)c3)n2)c1C>>Cc1c(C[C@@H](C)C(=O)O)cccc1-c1noc(-c2cnc(OC(C)C)c(Cl)c2)n1,,CC(C)O,O,Cl,[Na+].[OH-],val
US20110201650A1,CNO.COc1ccc(-n2nc(C3(O)CCNCC3)c(F)c2-c2ccc(C)cc2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1ccc(-n2nc(C3(O)CCN(C(=O)N(C)O)CC3)c(F)c2-c2ccc(C)cc2)cc1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20140349991A1,CCC(=O)OC(=O)CC.Cc1cc(O)c(C)c(O)c1>>CCC(=O)c1c(C)cc(O)c(C)c1O,,CCOC(C)=O,,O,,val
US04315933,CCN=C=O.Nc1ccc(-c2ncc(C(=O)O)c(O)n2)cc1>>CCNC(=O)Nc1ccc(-c2ncc(C(=O)O)c(O)n2)cc1,,CN(C)C=O,,CCN(CC)CC,,val
US20090076070A1,CC(C)N.Fc1ccc(-c2nc(-c3cccc4[nH]ccc34)no2)cc1C(F)(F)F>>CC(C)Nc1ccc(-c2nc(-c3cccc4[nH]ccc34)no2)cc1C(F)(F)F,,C1CCOC1,,,,val
US20050124654A1,COC(=O)c1ccc2c(c1)N(C)S(=O)(=O)CC2NC(=O)CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1>>CN1c2cc(CO)ccc2C(NC(=O)CC(NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O,,C1CCOC1,,CO,[BH4-].[Li+],val
US20150057260A1,CCOC(=O)c1nc(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)nc2c1cnn2C.N>>CN1CC[C@@](O)(C#Cc2cccc(-c3nc(C(N)=O)c4cnn(C)c4n3)c2)C1=O,,CO,,,,val
US20090264445A1,CC(C)(O)Cn1ccc(N)n1.O=C(O)[C@H](CC1CCCCC1)N1CC(Oc2c(F)cccc2F)=CC1=O>>CC(C)(O)Cn1ccc(NC(=O)[C@H](CC2CCCCC2)N2CC(Oc3c(F)cccc3F)=CC2=O)n1,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20080027041A1,CCC(=O)c1ccc(OC)cc1.CCOC(=O)CBr>>CCOC(=O)CC(C)C(=O)c1ccc(OC)cc1,,C1CCOC1,C1CCOC1,CC(C)[N-]C(C)C.[Li+],,val
US20130053386A1,Brc1cccc(I)c1.C#CC(=O)OCC>>CCOC(=O)C#Cc1cccc(Br)c1,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04382937,CC(=O)N(C)C1CCNC1.CCOC(=O)c1cn(CCF)c2nc(S(=O)(=O)CC)c(F)cc2c1=O>>CCOC(=O)c1cn(CCF)c2nc(N3CCC(N(C)C(C)=O)C3)c(F)cc2c1=O,,CCO,,CCN(CC)CC,,val
US20090270437A1,CI.CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5>>CI.CO[C@@]12CC[C@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5,,CC(=O)CC(C)C,,,,val
US05602117,O=C(CCl)C1CCCS1.O=C(COc1ccccc1)N[C@@H]1C(=O)N[C@@H]1S>>O=C(COc1ccccc1)N[C@@H]1C(=O)N[C@@H]1SCC(=O)C1CCCS1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20040209866A1,Cc1nc2c(cc1Br)c(=O)cc(Nc1ccccc1)n2-c1ccccc1.[Li]CCCC>>Cc1cc2c(=O)cc(Nc3ccccc3)n(-c3ccccc3)c2nc1C,,C1CCOC1,,,,val
US20090156642A1,CN(Cc1cc(Br)c(S(=O)(=O)c2ccccc2)s1)C(=O)OC(C)(C)C.OB(O)c1cccnc1F>>CN(Cc1cc(-c2cccnc2F)c(S(=O)(=O)c2ccccc2)s1)C(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20120101083A1,C=CC(=O)N(C)C.CC(C)Oc1ccc(-c2nc(-c3ccc4c(c3)CCNCC4)no2)cc1C#N>>CC(C)Oc1ccc(-c2nc(-c3ccc4c(c3)CCN(CCC(=O)N(C)C)CC4)no2)cc1C#N,,CC#N,,C1CCC2=NCCCN2CC1,Cl,val
US20100093728A1,ClCc1csc(-c2ccc(Cl)cc2)n1.N#Cc1c(N)nc(S)c(C#N)c1-c1ccc(OCCO)cn1>>N#Cc1c(N)nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1ccc(OCCO)cn1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20160272598A1,C=Cc1ccccc1.CC1(C)COC(=O)N1I.O>>OC(CI)c1ccccc1,,CC(C)=O,,,,val
US04661489,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.O=C1CNCC2c3ccccc3CCCN12>>O=C1CN(C(c2ccccc2)(c2ccccc2)c2ccccc2)CC2c3ccccc3CCCN12,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20090270350A1,COc1ccc(Cn2c(C)cc(OCc3ccccc3C#N)cc2=O)c(OC)c1.O=C1CCC(=O)N1Br>>COc1ccc(Cn2c(C)cc(OCc3ccccc3C#N)c(Br)c2=O)c(OC)c1,,CC#N,,,,val
US20150315165A1,CC1(C)OCC([C@@H](O)[C@H](O)C2COC(C)(C)O2)O1>>CC1(C)OC[C@H](C=O)O1,,ClCCl,,O=C([O-])O.[Na+],,val
US20140336415A1,CCOC(=O)C(=O)C(=O)OCC.COc1ccc(Nc2cccc(Cl)c2N)cc1>>CCOC(=O)c1nc2c(Cl)cccc2n(-c2ccc(OC)cc2)c1=O,,Cc1ccccc1,,,,val
US20060142321A1,Cl.NCCCN1CCc2cccc3c2C1CC3.O=S(=O)(Cl)c1ccc2c(c1)CCO2>>Cl.O=S(=O)(NCCCN1CCc2cccc3c2C1CC3)c1ccc2c(c1)CCO2,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US05648373,BrCCCCCCCCn1nc(-c2ccccc2)c(-c2ccccc2)n1.[C-]#N>>N#CCCCCCCCCn1nc(-c2ccccc2)c(-c2ccccc2)n1,,CS(C)=O,,O,,val
US20020022631A1,CCOC(=O)[C@@H](Cc1ccsc1)NC(C)=O>>CC(=O)N[C@@H](CO)Cc1ccsc1,,CCO,O,[BH4-].[Na+],,val
US20160264548A1,CC(C)(C)OC(=O)N1CCC(Nc2cnc(Oc3ccc(Oc4cccc(F)c4)cc3)c(C(N)=O)c2)C1>>NC(=O)c1cc(NC2CCNC2)cnc1Oc1ccc(Oc2cccc(F)c2)cc1,,C1COCCO1,ClCCl,Cl,,val
US20110114890A1,Brc1ccc(Br)nc1.OB(O)Oc1ccccc1>>Brc1ccc(-c2ccccc2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20060100226A1,Nc1cccc(CO)c1.O=C(Cl)c1ccc(Cl)c(Cl)c1>>O=C(Nc1cccc(CO)c1)c1ccc(Cl)c(Cl)c1,,C1COCCO1,O,CCN(CC)CC,Cl,val
US05756485,CC(COc1ccc(C(=O)OCc2ccccc2)c(O)c1)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C>>CC(COc1ccc(C(=O)O)c(O)c1)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C,[Pd],CCO,,C1=CCCCC1,,val
US20020103230A1,Nc1ccc(OCCN2CCOCC2)cc1[N+](=O)[O-]>>Nc1ccc(OCCN2CCOCC2)cc1N,[Pd],CCO,,,,val
US20140228303A1,CO[C@@]1(c2ccc(Cl)c(COc3ccccc3)c2)OC(CO)(CO)[C@@H](O)[C@H](O)[C@H]1O>>OC[C@@]12CO[C@@](c3ccc(Cl)c(COc4ccccc4)c3)(O1)[C@H](O)[C@@H](O)[C@@H]2O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120277224A1,COC(=O)CC(=O)c1ccccc1OC.Nc1[nH]ncc1-c1ccccn1>>COc1ccccc1-c1cc(=O)n2ncc(-c3ccccn3)c2[nH]1,,CC(=O)O,,,,val
US20150336925A1,CCOC(=O)c1[nH]c2ccccc2c1CCCOc1cccc2ccccc12.CI>>CCOC(=O)c1c(CCCOc2cccc3ccccc23)c2ccccc2n1C,,CN(C)C=O,,[H-].[Na+],,val
US20040162303A1,COc1ccc(F)cc1C(=O)c1cnc(NC2CCNCC2)nc1N.Cc1noc(C)c1S(=O)(=O)Cl>>COc1ccc(F)cc1C(=O)c1cnc(NC2CCN(S(=O)(=O)c3c(C)noc3C)CC2)nc1N,,C1CCOC1,,CCN(C(C)C)C(C)C,O,val
US20160159820A1,O=C1NCc2c(Oc3ccc4c(c3)[C@@H]3[C@H](O4)[C@H]3C(=O)O)ccnc2N1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=NC(=O)[C@H]1[C@@H]2c3cc(Oc4ccnc5c4CNC(=O)N5)ccc3O[C@@H]21,,C1COCCO1,,CCN(CC)CC,O,val
US04550107,C1CCC(CN2CCOCC2)NC1.O=C1Nc2cccnc2N(C(=O)CCl)c2ccccc21>>O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCOCC2)c2ccccc21,,CC#N,,,,val
US20120238543A1,Nc1c(S)cccc1Cl.O=[N+]([O-])c1cccc(Cl)c1Cl>>Nc1c(Cl)cccc1Sc1c(Cl)cccc1[N+](=O)[O-],,CCO,,[K+].[OH-],,val
US20060014962A1,CSc1nsc(Cl)n1.OCc1ccco1>>CSc1nsc(OCc2ccco2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20120010190A1,CON(C)C(=O)C[C@@H](c1ccc(Br)cc1)c1ccccc1C.COc1ncc(Br)cn1>>COc1ncc(C(=O)C[C@@H](c2ccc(Br)cc2)c2ccccc2C)cn1,,C1CCOC1,C1CCOC1,[Li]CCCC,[Cl-].[NH4+],val
US20030114453A1,CC(=O)O.CCOC(=O)NC(=O)c1nn(-c2cc(Cl)c(C(C)(C)c3noc(-c4ccccc4C)n3)c(Cl)c2)c(=O)[nH]c1=O>>Cc1ccccc1-c1nc(C(C)(C)c2c(Cl)cc(-n3nc(C(=O)O)c(=O)[nH]c3=O)cc2Cl)no1,,Cl,,,,val
US20030232860A1,COCC(=O)Cl.N#Cc1c(N)nc(OCC(F)F)c(C#N)c1-c1ccccc1F>>COCC(=O)Nc1nc(OCC(F)F)c(C#N)c(-c2ccccc2F)c1C#N,,C1CCOC1,,[Na+].[OH-],,val
US04239761,CCN(CC)C(=O)N1CCN(CCNC)CC1.CN(C)C(=O)Cl>>CCN(CC)C(=O)N1CCN(CCN(C)C(=O)N(C)C)CC1,,Cc1ccccc1,,CCN(CC)CC,,val
US04820834,CN1C(=O)[C@@H](N)N=C(c2ccccc2)c2ccccc21.O=C=Nc1ccccc1Cl>>CN1C(=O)[C@@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21,,C1CCOC1,,,,val
US20130172318A1,NC1CCCNC1=O.O=C(Cl)c1ccc(F)cc1>>O=C(NC1CCCNC1=O)c1ccc(F)cc1,,ClC(Cl)Cl,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090291978A1,CC(C)(C)OC(=O)N(Cc1ccc([N+](=O)[O-])cc1)[C@H](C(=O)OC1CCCC1)c1ccccc1>>CC(C)(C)OC(=O)N(Cc1ccc(N)cc1)[C@H](C(=O)OC1CCCC1)c1ccccc1,[Pd],CCOC(C)=O,,,,val
US04467125,Cc1cccc(C(F)(F)F)c1.O=[N+]([O-])O>>Cc1cccc(C(F)(F)F)c1[N+](=O)[O-],,ClCCl,,O,O=C([O-])O.[Na+],val
US20130059834A1,Cc1ccc2c(-c3cnc4[nH]cc(C(=O)NC(C)(C)CO[Si](C)(C)C(C)(C)C)c4n3)nn(CCCN(C)C)c2c1.Cl>>Cc1ccc2c(-c3cnc4[nH]cc(C(=O)NC(C)(C)CO)c4n3)nn(CCCN(C)C)c2c1.Cl,,CO,,,,val
US05405979,C[C@]12C[C@H](c3ccc(O)cc3)[C@@H]3[C@H]4CCC5(CC4=CC[C@H]3[C@@H]1CCC2=O)OCCO5.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>C[C@]12C[C@H](c3ccc(OS(=O)(=O)C(F)(F)F)cc3)[C@@H]3[C@H]4CCC5(CC4=CC[C@H]3[C@@H]1CCC2=O)OCCO5,CN(C)c1ccncc1,ClCCl,,O=C([O-])O.[Na+],,val
US20140323464A1,N#CCC(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1.O=Cc1ccccc1Cl>>N#CC(=Cc1ccccc1Cl)C(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US20080255083A1,BrCc1ccc(Br)cn1.O=c1cc(O)cnn1C1CCCCO1>>O=c1cc(OCc2ccc(Br)cn2)cnn1C1CCCCO1,,CC#N,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160130226A1,Brc1ccc(I)cc1.c1nc[nH]n1>>Brc1ccc(-n2cncn2)cc1,I[Cu]I,CN(C)C=O,,,,val
US04843087,O=C(NCCO)c1ccc(SSc2ccc(C(=O)NCCO)cc2)cc1>>c1cc(C2=NCCO2)ccc1SSc1ccc(C2=NCCO2)cc1,,CC(=O)OC(C)C,,O=S(Cl)Cl,,val
US20100249126A1,C1COCCN1.Clc1cc(Cl)nc(N2CCOCC2)n1>>Clc1cc(N2CCOCC2)nc(N2CCOCC2)n1,,CN1CCCC1=O,,CCN(CC)CC,CCOC(C)=O,val
US04436549,CC(C)(C)C1=NN=C(N)SC1.COc1cccc(OC)c1C(=O)Cl>>COc1cccc(OC)c1C(=O)NC1=NN=C(C(C)(C)C)CS1,,C1COCCO1,,CCN(CC)CC,O,val
US20020052346A1,COc1ccc(-c2ccc(CC(Cc3ccc(CP(=O)(OF)OF)cc3)(c3ccccc3)n3nnc4ccccc43)cc2)cc1P(=O)(OC)OC.C[Si](C)(C)Br>>COc1ccc(-c2ccc(CBr)cc2)cc1P(=O)(OC)OC,,ClCCl,,,,val
US20130017194A1,C=O.NC(=O)Cc1ccccc1CCc1nc(Nc2ccc3c(c2)CCNC3)ncc1C(F)(F)F>>CN1CCc2cc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)ccc2C1,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140171390A1,CC(=O)OCC[C@@H]1CC[C@@H](C(CCN)NC(=O)OC(C)(C)C)CC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(=O)OCC[C@@H]1CC[C@@H](C(CCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)CC1,,ClCCl,,,,val
US05631401,CC(C)CN.O=Cc1ccc(Oc2ccccc2)cc1>>CC(C)CNCc1ccc(Oc2ccccc2)cc1,[Pd],CCO,CCOCC,[H][H],,val
US20100305104A1,COc1ccccc1-c1noc(-c2ccc(N3CCOCC3)c([N+](=O)[O-])c2)n1>>COc1ccccc1-c1noc(-c2ccc(N3CCOCC3)c(N)c2)n1,,CCO,,,,val
US20120010191A1,CN.Cn1nc([N+](=O)[O-])cc1CBr>>CNCc1cc([N+](=O)[O-])nn1C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05175157,COc1cc2c(cc1OC)CC(=O)N(CC1CCCN(Cc3ccccc3)C1)C=C2>>COc1cc2c(cc1OC)CC(=O)N(CC1CCCNC1)CC2,[Pd],CC(=O)O,,[H][H],,val
US04118561,CI.Nc1nc(N)c2c(ccc3[nH]c4c(c32)CCCC4)n1>>Cn1c2c(c3c4c(N)nc(N)nc4ccc31)CCCC2,,CC(=O)O,,CN(C)C=O,[H-].[Na+],val
US20160031845A1,CCCCCCCCCCCCCCCC.CCOC(C)=O.Cc1ccccc1>>CC1(OCc2ccccc2)CC=CC1,,Cc1ccccc1,,,,val
US04352818,CN1Cc2cncn2-c2ccc(F)cc2C1=O.O=C1CCC(=O)N1Br>>CN1Cc2c(Br)ncn2-c2ccc(F)cc2C1=O,,CN(C)C=O,,O,,val
US20110118230A1,COC(=O)c1cc2c(cn1)[nH]c1ncc(Br)cc12.NN>>NNC(=O)c1cc2c(cn1)[nH]c1ncc(Br)cc12,,CCO,,O,,val
US05041448,CCOC(=O)NCCN1CCC(Nc2nc3cncnc3n2Cc2cccs2)CC1>>NCCN1CCC(Nc2nc3cncnc3n2Cc2cccs2)CC1,,CC(C)O,,[K+].[OH-],,val
US20040063954A1,CO.COC(OC)OC.O=C1CCN(c2ccc([N+](=O)[O-])cc2)CC1(F)F>>COC1(OC)CCN(c2ccc([N+](=O)[O-])cc2)CC1(F)F,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120214762A1,C=CC=O.c1c[nH]cn1>>OC1CCn2ccnc21,,C1COCCO1,,CC(=O)O,,val
US20020132810A1,CC(C)(F)CCC1CC(C(Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)OC1=O.NCCN>>CC(C)(F)CCC(CC(O)C(Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1=NCCN1,,Cc1ccccc1,,C[Al](C)C,,val
US20100009959A1,COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccccc3C=O)n(CC(N)C(=O)OC)c2c1>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(C(=O)OC)NCc1ccccc1-3,,CCOC(C)=O,ClCCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20150087631A1,Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1.O[C@@H]1CCCNC1>>c1ccc2oc(-c3cnc4ccc(O[C@@H]5CCCNC5)nn34)cc2c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20160052888A1,CCc1ccc(CO[C@@H]2CCc3cc([C@H]4CC[C@]5(COC(=O)N5)C4)ccc3C2)cc1>>CCc1ccc(CO[C@@H]2CCc3cc([C@H]4CC[C@](N)(CO)C4)ccc3C2)cc1,,C1COCCO1,O,[Li+].[OH-],,val
US20090054431A1,CC1(C(=O)O)Cc2ccccc2C1.OCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC1(NC(=O)OCc2ccccc2)Cc2ccccc2C1,,c1ccccc1,,CCN(CC)CC,Cl,val
US20100016340A1,N#CC1(c2cccc(Cl)c2)CCN(c2ncnc3[nH]cnc23)CC1>>NCC1(c2cccc(Cl)c2)CCN(c2ncnc3[nH]cnc23)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140323484A1,COc1ccccc1CN(CCc1ccc(NC(=O)Nc2cnc(C#N)cn2)cc1Cl)C(=O)OC(C)(C)C.Cl>>Cl.N#Cc1cnc(NC(=O)Nc2ccc(CCNCC3CCCCC3)c(Cl)c2)cn1,,C1COCCO1,ClCCl,,,val
US20050038057A1,Cc1c(-c2ccccc2Cl)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F.O=CCCC(=O)O>>Cc1c(-c2ccccc2Cl)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F,,CO,,c1ccncc1,,val
US20090281131A1,C=CC(=O)OC.CCOC(C)=O.COc1ccc(CC#N)c2c1oc1ccccc12>>COC(=O)CCC(C#N)(CCC(=O)OC)c1ccc(OC)c2oc3ccccc3c12,,CC#N,CCOC(C)=O,,,val
US20070037807A1,Cc1ccc(-c2c(C=O)c(C)nc(CC(C)C)c2CNC(=O)OC(C)(C)C)cc1.O=C1CSC(=O)N1>>Cc1ccc(-c2c(C=C3SC(=O)NC3=O)c(C)nc(CC(C)C)c2CNC(=O)OC(C)(C)C)cc1,,CCO,,C1CCNCC1,,val
US20080096874A1,CCOC(=O)C(C)=C1CCC(c2ccc(NC(=O)OCc3ccccc3)c(Cl)c2)CC1>>CCOC(=O)C(C)[C@@H]1CC[C@@H](c2ccc(N)c(Cl)c2)CC1,O=[Pt],CCOC(C)=O,,,,val
US04406909,CC(C)(CSc1ccc(Cl)cc1)C(=O)C(Oc1ccc(Cl)cc1)n1cncn1>>CC(C)(CSc1ccc(Cl)cc1)C(O)C(Oc1ccc(Cl)cc1)n1cncn1,,CO,O,[BH4-].[Na+],,val
US05225431,N#C[O-].N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O>>O=C1NC(=O)C(Cc2ccc([N+](=O)[O-])cc2)N1,,O,,Cl,,val
US20050096389A1,C1CCOC1.O.O=C(Cl)c1ccccc1.OCCO.c1ccncc1>>O=C(OCCOC(=O)c1ccccc1)c1ccccc1,,O,,,,val
US04040812,CN1CCC(O)N(c2nnc(C3CC3)s2)C1=O.COC(=O)Cl>>COC(=O)OC1CCN(C)C(=O)N1c1nnc(C2CC2)s1,,c1ccncc1,,,,val
US20080312208A1,CC(=O)CC(N)=O.CCOC(=O)/C(=C/N(C)C)C(C)=O>>CCOC(=O)c1cc(C(C)=O)c(=O)[nH]c1C,,CCO,,C,C[O-].[Na+],val
US05006157,CC(=O)OC(C)=O.CC(C)(c1ccccc1)N1CCC(O)C(c2ccccc2)C1=O>>CC(=O)OC1CCN(C(C)(C)c2ccccc2)C(=O)C1c1ccccc1,,c1ccncc1,,,,val
US20160083372A1,CC(C)(C)OC(=O)N[C@H](Cc1ccc(-c2ccccc2F)cc1)C[C@@](C)(CO)C(=O)O.O=C(O)c1c[nH]nn1>>C[C@@](CO)(C[C@@H](Cc1ccc(-c2ccccc2F)cc1)NC(=O)c1cnn[nH]1)C(=O)O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130059834A1,CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Br)nc12.CC1(C)OB(c2cccc3cc[nH]c23)OC1(C)C>>CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3cccc4cc[nH]c34)nc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20020156311A1,C=CCBr.N#Cc1ccc(O)cc1F>>C=CCOc1ccc(C#N)c(F)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20140200227A1,COC(=O)c1ccc(F)c(-c2c(F)cc(OC3CCCOC3)cc2F)n1>>O=C(O)c1ccc(F)c(-c2c(F)cc(OC3CCCOC3)cc2F)n1,,CO,,C1CCOC1,[Na+].[OH-],val
US20050014812A1,CC(=O)Nc1ccc(O)cc1[N+](=O)[O-].CCOC(=O)C(C)(C)CCBr>>CCOC(=O)C(C)(C)CCOc1ccc(NC(C)=O)c([N+](=O)[O-])c1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110183954A1,C1COCCN1.Cn1cnc(Nc2nc(Cl)nc(NC(c3ccc(F)cc3)c3nccn3C)n2)c1>>Cn1cnc(Nc2nc(NC(c3ccc(F)cc3)c3nccn3C)nc(N3CCOCC3)n2)c1,,CC#N,,,,val
US05110956,CCOC(=O)CSC(CC)c1cc2c(cc1CC)OCO2>>CCc1cc2c(cc1C(CC)SCC(=O)O)OCO2,,CCO,O,[Na+].[OH-],,val
US20160039838A1,C#Cc1cccc(Nc2ncnc3cc(O[C@H]4CCOC4)c(N)cc23)c1.O=C(Cl)/C=C/CN1C[C@H]2OCCO[C@H]2C1>>C#Cc1cccc(Nc2ncnc3cc(O[C@H]4CCOC4)c(NC(=O)/C=C/CN4C[C@H]5OCCO[C@H]5C4)cc23)c1,,C1CCOC1,ClCCl,O,O=C([O-])[O-].[Na+].[Na+],val
US04472433,CCOC(=O)Cc1cccc(Cl)c1[N+](=O)[O-].Sc1ccccc1Cl>>CCOC(=O)Cc1cccc(Sc2ccccc2Cl)c1[N+](=O)[O-],,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110288116A1,CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O.CC1(C)OC(=O)CC(=O)O1>>CC(C)(C)OC(=O)NC(Cc1c[nH]c2ccccc12)C(O)=C1C(=O)OC(C)(C)OC1=O,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US06548522B1,N#CC(c1ccccc1)c1ccccn1.O=S(=O)(O)O>>NC(=O)C(c1ccccc1)c1ccccn1,,O=S(=O)(O)O,,[Na+].[OH-],,val
US20090076070A1,CC(=O)O.N#Cc1ccc(N)c(N)c1>>Cc1nc2cc(C#N)ccc2[nH]1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US04587049,CCOC(=O)C1CC(=O)N1Cc1ccc(OC)cc1OC>>COc1ccc(CN2C(=O)CC2C(=O)O)c(OC)c1,,CCO,,O,[Na+].[OH-],val
US08754100B2,CC(C)(C)[Si](C)(C)OCc1cccc(N2CCCC2)c1>>OCc1cccc(N2CCCC2)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05939439,COC=NCC#N.Oc1ccc(Br)cc1>>Brc1ccc(Oc2c[nH]cn2)cc1,,CO,,[Na],,val
US20050026944A1,BrC(Br)(Br)Br.CC(C)(C)OC(=O)N1CCCC1C=O>>CC(C)(C)OC(=O)N1CCC[C@H]1C=C(Br)Br,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])O.[Na+],val
US20120283242A1,C/C(=C\C(=O)OCC[Si](C)(C)C)c1cc(C)c(Oc2ccc(O[Si](C)(C)C(C)(C)C)cn2)c(Cl)c1>>C/C(=C\C(=O)OCC[Si](C)(C)C)c1cc(C)c(Oc2ccc(O)cn2)c(Cl)c1,,CCO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20160145245A1,CC(CS(=O)(=O)Nc1cccc([C@@H](CN2CC[C@@H](O)C2)N(C)C(=O)Cc2ccc(Cl)c(Cl)c2)c1)O[Si](C)(C)C(C)(C)C>>CC(O)CS(=O)(=O)Nc1cccc([C@@H](CN2CC[C@@H](O)C2)N(C)C(=O)Cc2ccc(Cl)c(Cl)c2)c1,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080188500A1,COc1ccc(C(=O)Cl)cc1C(F)(F)F.Cc1ccc(N)cc1-c1ccc2[nH]c3ncncc3c2c1>>COc1ccc(C(=O)Nc2ccc(C)c(-c3ccc4[nH]c5ncncc5c4c3)c2)cc1C(F)(F)F,,C1CCOC1,CO,CCN(C(C)C)C(C)C,,val
US20150232459A1,COC(=O)c1cc(N)c(C)c([N+](=O)[O-])c1.[I-]>>COC(=O)c1cc(I)c(C)c([N+](=O)[O-])c1,,Cl,O,O=N[O-].[Na+],,val
US20090291967A1,CC(=N)N.CC(C)(C)c1ccc(C(=O)CCl)cc1>>Cc1ncc(-c2ccc(C(C)(C)C)cc2)[nH]1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120015052A1,COC(=O)c1ccc2c(-c3c(F)cccc3F)nn(-c3ccc(C)cc3)c2c1>>Cc1ccc(-n2nc(-c3c(F)cccc3F)c3ccc(C(=O)O)cc32)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20150266867A1,COc1ccc(CN2C(=O)[C@@H](NC(=O)OCc3ccccc3)[C@H]2CNCCO)c(OC)c1.O=C(n1ccnc1)n1ccnc1>>COc1ccc(CN2C(=O)[C@@H](NC(=O)OCc3ccccc3)[C@H]2CN2CCOC2=O)c(OC)c1,,ClC(Cl)Cl,,,,val
US20040220404A1,CCOC(COc1ccc(N)cc1OC)OCC.COC(=O)c1sc(-c2ccc(Cl)cc2)cc1N.COC(OC)N(C)C>>CCOC(COc1ccc(-n2cnc3cc(-c4ccc(Cl)cc4)sc3c2=O)cc1OC)OCC,,CCO,,,,val
US20050244332A1,C#CCCCCCCCCCCC=O.COc1cc(C)c(OC)c(OC)c1OC>>C#CCCCCCCCCCCC(O)c1c(C)c(OC)c(OC)c(OC)c1OC,,C1CCOC1,,CN(C)CCN(C)C,[Li]CCCC,val
US20120302540A1,CN1CC(c2ccccc2)C2(CCCN(C(=O)[C@@H](COCc3ccc(F)cc3)NC(=O)C(C)(C)NC(=O)OC(C)(C)C)C2)C1=O>>CN1CC(c2ccccc2)C2(CCCN(C(=O)[C@@H](COCc3ccc(F)cc3)NC(=O)C(C)(C)N)C2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US05578627,CS(=O)C[C@H](N)COc1noc2ccc(Cl)cc12.Cl>>CS(=O)C[C@H](N)COc1noc2ccc(Cl)cc12.Cl,,ClCCl,,CC(C)O,,val
US04699949,C1COCCN1.Cc1ccc(S(=O)(=O)OC(C)C(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC(C)C(=O)N2CCOCC2)cc1,,C1CCOC1,,,,val
US20140235609A1,NC(=O)c1ccc(Cl)nc1.OC1CCNCC1>>NC(=O)c1ccc(N2CCC(O)CC2)nc1,,CCN(C(C)C)C(C)C,,,,val
US05686424,CC[C@H](C)[C@H](N)C(=O)NCc1ccccc1.O=C(CBr)c1ccc(F)cc1.O=C(O)[C@@H]1CCCN1>>CC[C@H](C)[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)c1ccc(F)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20130023514A1,CC#N.COCCN.NNC(=O)[C@@H]1CC[C@@H](N(Cc2ccccc2)Cc2ccccc2)CC1>>COCCn1cnnc1[C@@H]1CC[C@@H](N(Cc2ccccc2)Cc2ccccc2)CC1,,C1CCOC1,O,CC(=O)O,,val
US20140296203A1,Cc1ccccc1[C@@H]1CN(C)[C@@H](C)[C@H]1[N+](=O)[O-]>>Cc1ccccc1[C@@H]1CN(C)[C@@H](C)[C@H]1N,[Zn],CO,,CC(=O)O,,val
US20030045558A1,CCOC(=O)C(CCOc1ccc(OC(C)(C)C(=O)OCC)cc1)NCc1ccccc1.O=C(Cl)c1ccc(-c2ccccc2)cc1>>CCOC(=O)C(CCOc1ccc(OC(C)(C)C(=O)OCC)cc1)N(Cc1ccccc1)C(=O)c1ccc(-c2ccccc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20020143012A1,O=C(CC(O)c1ccc([N+](=O)[O-])c(O)c1)c1ccc(Cl)c(Cl)c1>>Nc1ccc(CCC(O)c2ccc(Cl)c(Cl)c2)cc1O,[Ni],C1CCOC1,,,,val
US20040102437A1,c1ccc(COc2ccc(CN3CCC(Nc4ccc5[nH]ncc5c4)CC3)cc2)cc1>>Oc1ccc(CN2CCC(Nc3ccc4[nH]ncc4c3)CC2)cc1,[Pd],CCO,,,,val
US20160039797A1,C#Cc1cc(Nc2nccc(Oc3ccc(NC(=O)OC(C)(C)C)c4ccccc34)n2)cc(C(=O)NCCN2CCOCC2)c1>>C#Cc1cc(Nc2nccc(Oc3ccc(N)c4ccccc34)n2)cc(C(=O)NCCN2CCOCC2)c1,,ClCCl,,O,O=C(O)C(F)(F)F,val
US20100069404A1,CC(C)(C)OC(=O)N[C@H]1Cc2c(n(Cc3ccccn3)c3ccc(C#N)cc23)C1.Cl>>Cl.N#Cc1ccc2c(c1)c1c(n2Cc2ccccn2)C[C@@H](N)C1,,CCO,,[Na+].[OH-],,val
US20070281943A1,COC(=O)c1cc(Br)oc1CNCc1ccc(OC)cc1>>COc1ccc(CNCc2oc(Br)cc2C(=O)O)cc1,,O,,C1CCOC1,[Li+].[OH-],val
US20090192138A1,Cn1c(=O)n(Cc2nccc3ccccc23)c(=O)c2c1c(C#N)c(N1CCCN(C(=O)OC(C)(C)C)CC1)n2Cc1ccccc1.OO>>Cn1c(=O)n(Cc2nccc3ccccc23)c(=O)c2c1c(C(N)=O)c(N1CCCN(C(=O)OC(C)(C)C)CC1)n2Cc1ccccc1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US05187168,Clc1ccc2nc(Cl)nc(Cl)c2c1.NCc1ccc(-c2ccccc2C(=O)O)cc1>>O=C(O)c1ccccc1-c1ccc(CNc2nc(Cl)nc3ccc(Cl)cc23)cc1,,C1CCOC1,,CC(=O)[O-].[Na+],,val
US20160016907A1,BrP(Br)Br.CN1CC(=O)OB(c2ccc(CO)cc2)OC(=O)C1>>CN1CC(=O)OB(c2ccc(CBr)cc2)OC(=O)C1,,CC#N,ClCCl,,,val
US20090233919A1,COc1cc(-n2ccc3nc(-c4ccc(Cl)cc4)sc3c2=O)ccc1CCCN1CCCC1.Cl>>COc1cc(-n2ccc3nc(-c4ccc(Cl)cc4)sc3c2=O)ccc1CCCN1CCCC1.Cl,,CO,,,,val
US20130150339A1,O=S(=O)(Nc1ccncn1)c1ccc2c(Cl)nccc2c1.OB(O)c1cnn(-c2cccc(Cl)c2)c1>>O=S(=O)(Nc1ccncn1)c1ccc2c(-c3cnn(-c4cccc(Cl)c4)c3)nccc2c1,,O,,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20100010010A1,CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)C(=O)O.OC1CCCC1>>CC(C)(C)OC(=O)N[C@H](C(=O)OC1CCCC1)C1CCCCC1,CN(C)c1ccncc1,CN(C)C=O,,ClCCCl,,val
US20060194843A1,C#CC(C#N)=Cc1ccccc1.C[Si](C)(C)C=[N+]=[N-]>>C[Si](C)(C)c1[nH]nc(C#N)c1-c1ccccc1,,C1CCOC1,CCOC(C)=O,[Li]CCCC,,val
US20130102585A1,CC(C)(C)OC(=O)N1CCc2cc(C(=O)O)ccc2C1.O=C(c1nccs1)N1CCN(C2CNC2)CC1>>CC(C)(C)OC(=O)N1CCc2cc(C(=O)N3CC(N4CCN(C(=O)c5nccs5)CC4)C3)ccc2C1,,ClCCl,,CCN(CC)CC,ClCCCl,val
US20150119404A1,N=C(c1ccccc1)c1ccccc1.NC1CCCNC1=O>>O=C1NCCCC1N=C(c1ccccc1)c1ccccc1,,ClCCCl,,,,val
US07687522B2,Cn1c(Nc2ccccc2)ncc(-c2ccc(OCc3ccccc3)cn2)c1=O>>Cn1c(Nc2ccccc2)ncc(-c2ccc(O)cn2)c1=O,,ClCCl,O,BrB(Br)Br,,val
US20120046268A1,CC(C)(C)C(=O)Cl.NC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1>>CC(C)(C)C(=O)NC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,Cl,val
US05677305,O=c1[nH]c2cc(F)c([N+](=O)[O-])cc2[nH]c1=O.Oc1ccncc1F>>O=c1ccn(-c2cc3[nH]c(=O)c(=O)[nH]c3cc2[N+](=O)[O-])cc1F,,CS(C)=O,,Cl,[K+].[OH-],val
US20120108568A1,Fc1ccc(F)c([C@H]2CCCN2)c1.N#Cc1cnn2ccc(O)nc12>>N#Cc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20030212063A1,O=C(Cc1nc(-c2ccc(OCCNC[C@H](O)c3ccc(Cl)nc3)cc2)co1)N1CCCC1>>O=C(Cc1nc(-c2ccc(OCCNC[C@H](O)c3cccnc3)cc2)co1)N1CCCC1,[Pd],CCOCC,CO,O=C[O-].[NH4+],,val
US05322942,Br.CC[C@H](C(=O)OC)[C@H](N)C(=O)O>>CC[C@@H](C(=O)OC)[C@H](Br)C(=O)O,,Br,,O=N[O-].[Na+],,val
US20120114739A1,CCOC(=O)CC(=O)OCC.Nc1cc[nH]n1>>Oc1cc(O)n2nccc2n1,,CCO,,C,C[O-].[Na+],val
US20110021573A1,CCOC(=O)C(C)c1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CN2C(=O)O[C@H](c3ccccc3)[C@@H]2C)c1>>COc1ccc(C(C)C(=O)O)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2ccccc2)[C@@H]1C,,CO,,[Li+].[OH-],,val
US06495564B1,Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2CC1CC1.O=S(Cl)Cl>>Cn1cncc1C(Cl)(c1ccc(Cl)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2CC1CC1,,ClCCl,,,,val
US20150284343A1,FC(F)(F)Oc1cccc(Oc2nn(-c3ccc(C(F)(F)F)cc3)nc2CBr)c1>>Cc1nn(-c2ccc(C(F)(F)F)cc2)nc1Oc1cccc(OC(F)(F)F)c1,[Pd],,,,,val
US06121271,CCc1ccccc1OC.O=C(Cl)c1ccccc1Cl>>CCc1cc(C(=O)c2ccccc2Cl)ccc1OC,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20150307451A1,BrCc1ccc(-n2cccn2)cc1.COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)c(C2CC2)cc1O>>COC(=O)c1cc(Cc2ccc(-n3cccn3)cc2)c(C2CC2)cc1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US05856576,BrC(Br)(Br)Br.O=C(CCCO)c1ccccc1[N+](=O)[O-]>>O=C(CCCBr)c1ccccc1[N+](=O)[O-],,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130165436A1,CCC(=O)N1CC[C@@H](O)C1.CS(=O)(=O)Cl>>CCC(=O)N1CC[C@@H](OS(C)(=O)=O)C1,,ClCCl,,CCN(CC)CC,O,val
US20120184542A1,CC(C)(C)CN.Nc1cc(C(=O)On2nnc3ccccc32)ccc1Cl>>CC(C)(C)CNC(=O)c1ccc(Cl)c(N)c1,,ClCCl,,CCN(CC)CC,CN(C)C=O,val
US20100056515A1,CCC(CC)c1ccc(Cl)c2nc(Cl)n(CCO)c12.COc1ccc(CO)cc1>>CCC(CC)c1ccc(Cl)c2nc(Cl)n(CCOCc3ccc(OC)cc3)c12,,C1CCOC1,O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080207654A1,CCCc1nc(C)n(-c2ccc3c(c2)CCC(C)(C)O3)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1F.O=C([O-])O.[NH3+]O>>CCCc1nc(C)n(-c2ccc3c(c2)CCC(C)(C)O3)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1F,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20140309193A1,CC(C)(C)OC(=O)C(C)(C)CO.COCCOCCOCCOCCOCCOCCOCCOS(C)(=O)=O>>COCCOCCOCCOCCOCCOCCOCCOCC(C)(C)C(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20120302540A1,CN1CC(c2ccccc2)C2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)NC(=O)OC(C)(C)C)C2)C1=O>>CN1CC(c2ccccc2)C2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C2)C1=O,,CO,ClCCl,O=C(O)C(F)(F)F,,val
US20080027036A1,Nc1ccc(Cc2ccccc2)cc1I.O=Cc1ccc(C(=O)Cl)c(F)c1>>O=Cc1ccc(C(=O)Nc2ccc(Cc3ccccc3)cc2I)c(F)c1,,C1CCOC1,CCOCC,CCN(C(C)C)C(C)C,Cl,val
US03995060,CC(C)C(=O)Cl.Nc1ccc(Br)c(C(F)(F)F)c1>>CC(C)C(=O)Nc1ccc(Br)c(C(F)(F)F)c1,,c1ccncc1,,,,val
US20060135552A1,CC(=O)CC(=O)C(F)(F)F.COc1ccc(C(=O)c2c(N)sc3c2CCC3)cc1>>COc1ccc(-c2c(C(=O)C(F)(F)F)c(C)nc3sc4c(c23)CCC4)cc1,O=S(=O)(O)O,CC(=O)O,,,,val
US05081255,COc1cc(OC)cc(C(=O)NNC(=O)c2cc(OC)cc(OC)c2)c1>>COc1cc(OC)cc(-c2nnc(-c3cc(OC)cc(OC)c3)o2)c1,,O=P(Cl)(Cl)Cl,,CO,O,val
US20030125339A1,CN1CCC(N2CC(C)(C)c3ccc([N+](=O)[O-])cc32)CC1>>CN1CCC(N2CC(C)(C)c3ccc(N)cc32)CC1,,CO,,,,val
US20150038574A1,CC1=C(C=O)C(C)(C)CCC1.Nc1ccc2c(c1)OC(F)(F)O2>>CC1=C(CNc2ccc3c(c2)OC(F)(F)O3)C(C)(C)CCC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20120277207A1,C=C(C)COC1CN(C(c2ccccc2)c2ccccc2)C1.ClCCCl>>C=C(C)COC1CNC1.Cl,,CO,,CC(Cl)OC(=O)Cl,,val
US06232290B1,BrC1C=CCCC1.CCOC(=O)c1ccc(N2CCC(O)CC2)cc1>>CCOC(=O)c1ccc(N2CCC(OC3C=CCCC3)CC2)cc1,O=[Ag],C1CCOC1,,,,val
US20030013715A1,CC(CN)c1ccccc1.O=C(Cl)c1cnc2ccccc2n1>>CC(CNC(=O)c1cnc2ccccc2n1)c1ccccc1,,c1ccncc1,,,,val
US20070142638A1,COC(=O)CCc1ccccc1NC(=O)[C@H](CCCNC(=O)OCc1ccccc1)NC(=O)c1cn(C)c2ccccc12>>Cn1cc(C(=O)N[C@@H](CCCNC(=O)OCc2ccccc2)C(=O)Nc2ccccc2CCC(=O)O)c2ccccc21,,C1COCCO1,,Cl,[Na+].[OH-],val
US20040242584A1,COC(=O)c1ccc(-c2ccccc2Cl)cc1>>O=C(O)c1ccc(-c2ccccc2Cl)cc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20090221576A1,N#Cc1ccc2[nH]c(O)c(-c3ccc(CN4CCOCC4)cn3)c2c1.O=S(=O)(O)CCS(=O)(=O)O>>N#Cc1ccc2[nH]c(O)c(-c3ccc(CN4CCOCC4)cn3)c2c1.O=S(=O)(O)CCS(=O)(=O)O,,CCO,,,,val
US05919781,BrCc1ccccc1.Oc1ccc(OC(F)(F)F)cc1>>FC(F)(F)Oc1ccc(OCc2ccccc2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20140213588A1,O=C(O)CCCc1ccc(Cl)c(Cl)c1>>OCCCCc1ccc(Cl)c(Cl)c1,,C1CCOC1,,B,,val
US20070010542A1,Cc1c(OCC2COC(C)(C)OC2)ccnc1CSc1nc2ccccc2[nH]1.O=C(OO)c1cccc(Cl)c1>>Cc1c(OCC2COC(C)(C)OC2)ccnc1CS(=O)c1nc2ccccc2[nH]1,,CO,Cc1ccccc1,O=C([O-])O.[Na+],,val
US20130150341A1,CC1(Nc2ccccc2N)CCN(Cc2ccccc2)CC1.O=C(n1ccnc1)n1ccnc1>>CC1(n2c(=O)[nH]c3ccccc32)CCN(Cc2ccccc2)CC1,,ClCCl,,O,,val
US20080096903A1,CC(CCO)n1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc21.NS(=O)(=O)Cl>>CC(CCOS(N)(=O)=O)n1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc21,,CN(C)C=O,,O=C([O-])[O-].[Ca+2],,val
US08129538B1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)CCN[C@H](CO)CC(=O)N(Cc1cccc(Cl)c1Cl)C1CC1>>COC(=O)CCN(C(=O)OC(C)(C)C)[C@H](CO)CC(=O)N(Cc1cccc(Cl)c1Cl)C1CC1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20020077356A1,CCOC(=O)C(=CC1(c2ccccc2Cl)CC1)OCC>>CCOC(=CC1(c2ccccc2Cl)CC1)C(=O)O,,[Na+],[OH-],,,val
US06060462,CCOC(=O)CN(C)C(=O)c1ccccc1-c1ccccc1C>>Cc1ccccc1-c1ccccc1C(=O)N(C)CC(=O)O,,CO,O,[K+].[OH-],,val
US20090075869A1,C=CCCCNC.COC(=O)[C@@H](N=C=O)C(C)C>>C=CCCCN(C)C(=O)N[C@H](C(=O)OC)C(C)C,,C1CCOC1,,,,val
US20100137313A1,COc1cc(Nc2ncc(-c3cnc(OC)c(C#N)c3)c(-n3nc(C(F)(F)F)cc3C)n2)cc(OC)c1.C[Si](C)(C)N=[N+]=[N-]>>COc1cc(Nc2ncc(-c3cnc(OC)c(-c4nnn[nH]4)c3)c(-n3nc(C(F)(F)F)cc3C)n2)cc(OC)c1,,C1COCCO1,,CCCC[Sn](=O)CCCC,,val
US20050267134A1,CC1(C)OC2C(CO)OC(n3cnc4c(Cl)ncnc43)C2O1.COC(=O)c1cc(O)no1>>COC(=O)c1cc(OCC2OC(n3cnc4c(Cl)ncnc43)C3OC(C)(C)OC23)no1,,ClCCl,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130045964A1,NC1CCC1.O=C(O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1>>O=C(NC1CCC1)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120184539A1,CC(CO)(NC(=O)CCl)c1cccc(Br)n1>>CC1(c2cccc(Br)n2)COCC(=O)N1,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20100152462A1,CCOC(=O)C#Cc1ccc(F)c(F)c1.COCN(Cc1ccccc1)C[Si](C)(C)C>>O=C(O)C1=C(c2ccc(F)c(F)c2)CN(Cc2ccccc2)C1,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20130109682A1,CC1OC(c2ccncc2[N+](=O)[O-])C(F)C(=O)C1(C)O[Si](C)(C)C>>CC1OC(c2ccncc2[N+](=O)[O-])C(F)C(=O)C1(C)O,,C1CCOC1,CO,Cl,,val
US20040209865A1,C1COCCN1.OCc1ccc(CCC#Cc2ccc(Br)cn2)cc1>>Brc1ccc(C#CCCc2ccc(CN3CCOCC3)cc2)nc1,,ClCCl,,CCN(C(C)C)C(C)C,CS(=O)(=O)Cl,val
US20110065691A1,COc1ccc(N2CCN[C@@H](Cc3ccccc3)C2)cc1OC1CCCC1.O=C(O)C(=O)c1cccs1>>COc1ccc(N2CCN(C(=O)C(=O)c3cccs3)[C@@H](Cc3ccccc3)C2)cc1OC1CCCC1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04675328,Nc1ccc(C(=O)c2ccccc2)cc1.O=C(Cl)CCCl>>O=C(CCCl)Nc1ccc(C(=O)c2ccccc2)cc1,,ClC(Cl)Cl,,[Na+].[OH-],,val
US20070155805A1,BrC(Br)(Br)Br.COCCC(CCO)c1sc2cc(C(F)(F)F)ccc2c1C>>COCCC(CCBr)c1sc2cc(C(F)(F)F)ccc2c1C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US08455671B2,CN(C)[C@@H]([C]1[CH][CH][CH][C]1P(c1ccccc1)c1ccccc1)c1cccc(P(c2ccccc2)c2ccccc2)c1.[CH]1[CH][CH][CH][CH]1.[Fe]>>CN(C)[C@H]([C]1[CH][CH][CH][C]1P(c1ccccc1)c1ccccc1)c1ccccc1P(c1ccccc1)c1ccccc1.[CH]1[CH][CH][CH][CH]1.[Fe],,ClCCl,,,,val
US20060217427A1,C=CCCCC=O.CC(=O)N1C(=S)SC[C@H]1C(C)C>>C=CCCC[C@@H](O)CC(=O)N1C(=S)SC[C@H]1C(C)C,Cl[Ti](Cl)(Cl)Cl,ClCCl,,CCN(C(C)C)C(C)C,,val
US05202335,CCCOC(=O)C(CC(=O)N1C[C@@H]2CC=CC[C@@H]2C1)Cc1ccccc1>>O=C(O)C(CC(=O)N1C[C@@H]2CC=CC[C@@H]2C1)Cc1ccccc1,,CCO,,[Na+].[OH-],,val
US20120220609A1,CC(C)(C)[Si](C)(C)Cl.CC(C)(O)c1cc(Br)ccc1CCO>>CC(C)(O)c1cc(Br)ccc1CO[Si](C)(C)C(C)(C)C,,CN(C)C=O,,O,c1c[nH]cn1,val
US20100204226A1,CCOC(=O)c1cnn(-c2nc3ccc(NC(=O)c4ccccc4)cc3c(=O)[nH]2)c1>>O=C(O)c1cnn(-c2nc3ccc(NC(=O)c4ccccc4)cc3c(=O)[nH]2)c1,,C1CCOC1,,[K+].[OH-],,val
US20090275592A1,CC(C)(C)OC(=O)N[C@H](CCc1cc(-c2ccc3cnccc3c2)no1)Cc1ccccc1>>N[C@H](CCc1cc(-c2ccc3cnccc3c2)no1)Cc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020028748A1,CI.Cn1cccc1-c1nsc2ccc(-n3c(=O)cc(C(F)(F)F)[nH]c3=O)cc12>>Cn1cccc1-c1nsc2ccc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)cc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04433150,COc1ccc2nccc(CCC3CCN(C(=O)c4ccccc4)CC3)c2c1.O=C(O)c1ccccc1C(=O)OO>>COc1ccc2c(c1)c(CCC1CCN(C(=O)c3ccccc3)CC1)cc[n+]2[O-],,CCOCC,CO,[Na+].[OH-],,val
US20020013318A1,CCCCO.O=c1c(Cl)c(Cl)cnn1-c1ccc(F)c(F)c1>>CCCCOc1c(Cl)cnn(-c2ccc(F)c(F)c2)c1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20100164368A1,CC(C)O.ClCC1CO1.O.Oc1cc(O)c(Cl)cc1Cl>>OC1=C2C3OC3COCC3OC3C(Cl)(C=C1Cl)C2O,,O,,[Na+].[OH-],,val
US04957609,CN(C)CC1CCC(NCc2ccccc2I)=CC1=O.Cc1ncc[nH]1>>Cc1nccn1CC1CCC(NCc2ccccc2I)=CC1=O,,CN(C)C=O,,Cl,,val
US20070060558A1,CC(C)(C)OC(=O)N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CSCCNc3ccnc4cc(Cl)ccc34)CS[C@H]12.Cl>>N[C@@H]1C(=O)N2C(C(=O)O)=C(CCl)CS[C@H]12,,O=CO,,,,val
US20040132727A1,COc1cc2nccc(Oc3ccc(NC(=O)CCOc4ccccc4C)c(C)c3C)c2cc1OC>>COc1cc2nccc(Oc3ccc(NCCCOc4ccccc4C)c(C)c3C)c2cc1OC,,C1CCOC1,,Cl,[Na+].[OH-],val
US20120142714A1,CCOC(C)=O.CCOc1ccc2c(F)c(-c3ccc(OC[C@H](C)NC(=O)OC(C)(C)C)cc3F)nn2c1>>CCOc1ccc2c(F)c(-c3ccc(OC[C@H](C)NC(C)=O)cc3F)nn2c1,,CCOC(C)=O,,Cl,,val
US20020091148A1,CCOC(=O)c1cc2ccccc2[nH]1.ClP(Cl)(Cl)(Cl)Cl>>CCOC(=O)c1[nH]c2ccccc2c1Cl,,Cc1ccccc1,,,,val
US20150158863A1,FC(F)(F)Oc1ccc(I)cc1.O=C(O)C1CCCCN1>>O=C(O)C1CCCCN1c1ccc(OC(F)(F)F)cc1,[Cu]I,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090214860A1,Nc1cc(C23CC4CC(C2)CC(c2ccc(O)c(N)c2)(C4)C3)ccc1O.O=C(Cl)c1cc(C#Cc2ccccc2)cc(C(=O)Cl)c1>>c1ccc2ocnc2c1,,CN1CCCC1=O,,O,c1ccncc1,val
US20150191461A1,CS(=O)(=O)Cl.O=C1CC(CO)C2(CC2)N1>>CS(=O)(=O)OCC1CC(=O)NC12CC2,,ClCCl,O,CCN(CC)CC,,val
US20060292079A1,Cn1ccc(C(=O)NCCN(CCNC(=O)c2ccn(C)c(=O)c2OCc2ccccc2)CC(CCCC(=O)O)NC(=O)c2ccc(C(=O)O)c(OCc3ccccc3)c2OCc2ccccc2)c(OCc2ccccc2)c1=O>>Cn1ccc(C(=O)NCCN(CCNC(=O)c2ccn(C)c(=O)c2O)CC(CCCC(=O)O)NC(=O)c2ccc(C(=O)O)c(O)c2O)c(O)c1=O,,CC(=O)O,,Cl,,val
US20120202853A1,CCOC(C)=C(C#N)C#N.COc1ccc(NN)c(F)c1>>COc1ccc(-n2nc(C)c(C#N)c2N)c(F)c1,,CCO,,Cl,ClCCl,val
US04931452,N#CCBr.Oc1ncc(OC(F)(F)C(F)F)cc1F>>N#CCn1cc(OC(F)(F)C(F)F)cc(F)c1=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04060630,CCN(CC)CCCl.Nc1cc(Cl)ccc1Cl.O=C(CCl)c1ccccc1>>CCN(CC)CCN(CC(=O)c1ccccc1)c1cc(Cl)ccc1Cl,,CCN(CC)CC,,COCCOC,,val
US04260619,CC(=O)NC(C)Cc1ccc(OC(C)=O)cn1>>CCNC(C)Cc1ccc(O)cn1,,C1CCOC1,Cc1ccccc1,[Na+].[OH-],,val
US20040152895A1,CCCBr.O=c1cc[nH]c(=S)[nH]1>>CCCSc1nccc(O)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06130239,C#CCCCO.COc1cc[nH]c1/C=C1\C(=O)Nc2cccc(Br)c21>>COc1cc[nH]c1/C=C1\C(=O)Nc2cccc(C#CCCCO)c21,,CCN(CC)CC,CN(C)C=O,C[Si](C)(C)Cl,,val
US20120022107A1,CCOC(=O)c1[nH]c(C)c(Br)c1Br.N#C[Cu]C#N>>CCOC(=O)c1[nH]c(C)c(Br)c1C#N,,CN(C)C=O,O,,,val
US20100240678A1,CCOC(=O)CCc1cccc(CCC(CC(C)Oc2ccccc2-c2ccc3c(c2)OCCO3)C(C)=O)c1OC(C)CC(=O)OCC>>CC(=O)C(CCc1cccc(CCC(=O)O)c1OC(C)CC(=O)O)CC(C)Oc1ccccc1-c1ccc2c(c1)OCCO2,,[Na+],[OH-],,,val
US20080153852A1,Cc1cscc1-c1ccccc1C(Oc1cc(Cl)nc(N)n1)C(F)(F)F.N[C@@H](Cc1ccc(B(O)O)cc1)C(=O)O>>Cc1cscc1-c1ccccc1C(Oc1cc(-c2ccc(C[C@H](N)C(=O)O)cc2)nc(N)n1)C(F)(F)F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,CC#N,O=C([O-])[O-].[Na+].[Na+],val
USRE029843,CCOC(=O)[C@H](CC(C)C)NC(C)=O.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CCOc1sc(C)nc1CC(C)C,,ClC(Cl)Cl,,[K+].[OH-],,val
US20030207900A1,CS(=O)(=O)c1ncc2ccsc2n1.NC1CCOCC1>>c1cc2cnc(NC3CCOCC3)nc2s1,,CCOC(C)=O,O,CN1CCCC1=O,,val
US20060173019A1,CN(c1ccccc1)c1ccc(F)cc1.COCN(c1cc(Cl)cnc1C(=O)O)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>COCN(c1cc(Cl)cnc1C(=O)N(C)c1ccc(F)cc1)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US04146721,CO.O=C(O)Cc1c(-c2ccccc2)nn(-c2ccccc2)c1-c1ccccc1>>COC(=O)Cc1c(-c2ccccc2)nn(-c2ccccc2)c1-c1ccccc1,,ClC(Cl)(Cl)Cl,,O=S(=O)(O)O,,val
US20110224193A1,O=[N+]([O-])c1ccc(N2CCC(O)(c3ccccc3)CC2)nc1>>Nc1ccc(N2CCC(O)(c3ccccc3)CC2)nc1,[Pd],CCO,CCOC(C)=O,,,val
US20140031364A1,COC(=O)c1c(-c2cccc(F)c2)noc1N>>Nc1onc(-c2cccc(F)c2)c1C(=O)O,,CO,,[Na+].[OH-],,val
US20080279800A1,CC(O)C(C)C(C)C(C)C(C)(C)C>>CC(=O)C(C)C(C)C(C)C(C)(C)C,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20040162303A1,CN(C)C=O.Fc1cc(Br)c2occc2c1>>O=Cc1cc(F)cc2ccoc12,,C1CCOC1,CCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20100179148A1,CCOC(=O)Nc1cccc(Cn2nc(C(N)=S)ccc2=O)c1.O=C(CBr)c1ccc(N2CCCC2)cc1>>CCOC(=O)Nc1cccc(Cn2nc(-c3nc(-c4ccc(N5CCCC5)cc4)cs3)ccc2=O)c1,,CCO,,,,val
US06204294B1,C=CCc1c(C#N)ccc(N)c1O>>CCCc1c(C#N)ccc(N)c1O,[Pd],CCOC(C)=O,,[H][H],,val
US06281363B1,CC(C)C[C@@H](C(=O)O)[C@H](C/C=C/c1ccccc1)C(=O)OC(C)(C)C>>CC(C)C[C@@H](C(=O)O)[C@H](CCCc1ccccc1)C(=O)OC(C)(C)C,[Pd],CC(C)O,,,,val
US20110071149A1,CCOC(C)=O.Nc1cccc(-c2cnc3ccccc3n2)c1.O=C(Cl)CCCl>>O=C(CCCCl)Nc1cccc(-c2cnc3ccccc3n2)c1,,CCOC(C)=O,,C1CCOC1,CCN(C(C)C)C(C)C,val
US20130053384A1,CON(C)C(=O)c1ccc2ncc(Cl)nc2c1.OB(O)c1ccc(Cl)cc1>>CON(C)C(=O)c1ccc2ncc(-c3ccc(Cl)cc3)nc2c1,,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US04657916,COC(C)(C)OC.O=CCCCCCCCCCCc1cc(OCc2ccccc2)c2ccccc2[n+]1[O-]>>COC(CCCCCCCCCCc1cc(OCc2ccccc2)c2ccccc2[n+]1[O-])OC,,ClCCl,,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US06228870B1,CC(C)(C)OC(=O)NCCCN1CCC(c2ccccc2C#N)CC1.Cl>>Cl.N#Cc1ccccc1C1CCN(CCCN)CC1,,CCOC(C)=O,,,,val
US20110053904A1,COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)N[C@@H]1CCCC[C@@H]1N.O=CC1CC1>>COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)N[C@@H]1CCCC[C@@H]1NCC1CC1,,CO,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20030149001A1,CC(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cn3)nc2n(C2CCCC2)c1=O.Cl>>CC(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O.Cl,,CO,ClCCl,,,val
US20160024044A1,CCOC(=O)NCC(c1ccc(Cl)c(Cl)c1)C(O)c1cncc(OC)c1>>COc1cncc(C(O)C(CN)c2ccc(Cl)c(Cl)c2)c1,,C1CCOC1,,B,,val
US04898872,COc1ccc2cc(C(=O)O)cc(C)c2n1.Nc1ccccc1N>>COc1ccc2cc(-c3nc4ccccc4[nH]3)cc(C)c2n1,,O=P(Cl)(Cl)Cl,,,,val
US04918195,CON=O.Nc1ccccc1N.O=N[O-]>>c1ccc2[nH]nnc2c1,,CO,,O=S(=O)(O)O,,val
US20150344473A1,CCOC(=O)c1ccc(N2CCNC(C)C2)cc1.FCCBr>>CCOC(=O)c1ccc(N2CCN(CCF)C(C)C2)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],,val
US20040087585A1,CCCCNN.O=C(Cl)Oc1ccccc1>>CCCCN(N)C(=O)Oc1ccccc1,,ClCCl,,CCN(CC)CC,O,val
US20070155805A1,Cc1c(CCC(=O)OC(C)(C)C)sc2ccc(Br)cc12>>Cc1c(CCCO)sc2ccc(Br)cc12,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20100041667A1,CCCCN1CCN(C(C(=O)OC)c2ccccc2)C(=O)C1=O>>CCCCN1CCN(C(C(=O)O)c2ccccc2)C(=O)C1=O,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US06229020B1,C/C(=C\c1ccc2cc(N)ccc2c1)C(=O)O.O=[N+]([O-])c1ccc(O)cc1>>CC(=Cc1ccc2cc(N)ccc2c1)C(=O)Oc1ccc([N+](=O)[O-])cc1,CN(C)c1ccccn1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20160002175A1,Cc1ccc(S(=O)(=O)N2CCOCC2)cc1B(O)O.Nc1nc(Cl)cc(NCCCN2CCCC2=O)n1>>Cc1ccc(S(=O)(=O)N2CCOCC2)cc1-c1cc(NCCCN2CCCC2=O)nc(N)n1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20160129002A1,FC(F)(F)COCc1cc(Cl)nc(Cl)n1.NCC1CC1>>FC(F)(F)COCc1cc(NCC2CC2)nc(Cl)n1,,CC#N,CO,,,val
US05192786,O=C(c1ccc(Cl)cc1)c1ccc(OCCCCl)cc1.c1c[nH]cn1>>Cl.O=C(c1ccc(Cl)cc1)c1ccc(OCCCn2ccnc2)cc1,,COCCOCCOC,,,,val
US08138168B1,CC(C)(C)OC(=O)N[C@@H](CC(=O)N1CCC[C@@H](c2nc3ccccc3[nH]2)C1)Cc1ccc(-c2ccccc2)cc1>>N[C@@H](CC(=O)N1CCC[C@@H](c2nc3ccccc3[nH]2)C1)Cc1ccc(-c2ccccc2)cc1,,ClCCl,,,,val
US05614517,COC(=O)/C=C/c1c2n(c(=O)c3cc(OC)ccc13)CCc1ccccc1-2>>COC(=O)CCc1c2n(c(=O)c3cc(OC)ccc13)CCc1ccccc1-2,[Pd],CC(=O)O,,,,val
US04242355,CCCI.COc1cccc(CCNCCC2CCCCC2)c1>>CCCN(CCc1cccc(OC)c1)CCC1CCCCC1,,CC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100130495A1,CCC=O.OCCN(c1ccccc1)c1nc(Nc2ccc(-c3cnco3)cc2)nc2c1CNCC2>>CCCN1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(N(CCO)c3ccccc3)c2C1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20040019210A1,COc1c(F)c(NCc2ccccc2)c(F)c(OC)c1C(=O)O>>COc1cc(OC)c(F)c(NCc2ccccc2)c1F,,Clc1ccccc1,,,,val
US20150005232A1,CS(=O)(=O)Cl.Cc1nc(N)ccc1Br>>Cc1nc(NS(C)(=O)=O)ccc1Br,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160046564A1,Cc1cc([N+](=O)[O-])c(C)cc1OCC1CC1>>Cc1cc(OCC2CC2)c(C)cc1N,[Fe],O,,CC(=O)O,,val
US06777395B2,CC(=O)OC1O[C@H](COC(=O)c2ccc(C)cc2)[C@@H](F)[C@H]1OCc1ccccc1.Nc1nc(Cl)c2cc[nH]c2n1>>Cc1ccc(C(=O)OC[C@H]2O[C@@H](n3ccc4c(Cl)nc(N)nc43)[C@H](OCc3ccccc3)[C@@H]2F)cc1,,CC#N,ClCCl,CC(=O)O,[H-].[Na+],val
US04025630,CCCC(C)(c1ccc(F)cc1)c1cc(O)c2c(c1)OC(C)(C)C1=C2CC(C)CC1.Cl.O=C(O)CCCN1CCCCC1>>CCCC(C)(c1ccc(F)cc1)c1cc(OC(=O)CCCN2CCCCC2)c2c(c1)OC(C)(C)C1=C2CC(C)CC1.Cl,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20040209905A1,COc1cc2ncnc(Oc3ccc(N)c(F)c3)c2cc1OC.NCc1ccc(F)cc1F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)NCc4ccc(F)cc4F)c(F)c3)c2cc1OC,,CCN(CC)CC,ClC(Cl)Cl,,,val
US20040176367A1,CCOC(CCNC(=O)OC(C)(C)C)OCC.CCOCc1nc2cnc3ccccc3c2n1N>>CCOCc1nc2cnc3ccccc3c2n1N=CCCNC(=O)OC(C)(C)C,,CC#N,CC(=O)O,,,val
US20030149033A1,NO.O=C(C[N+](=O)[O-])C1CCCC1>>O=[N+]([O-])CC(=NO)C1CCCC1,,CCO,Cc1ccccc1,O=S(=O)(O)O,,val
US06380218B1,N#Cc1cccc(Oc2ncccc2C(=O)O)c1.NCc1ccc(S(N)(=O)=O)cc1>>N#Cc1cccc(Oc2ncccc2C(=O)NCc2ccc(S(N)(=O)=O)cc2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20130210785A1,CC1([C@H]2CC[C@H]3[C@@H]4CCC5=C/C(=N/O)CC[C@]5(C)[C@H]4CC[C@@]32C)OCCO1>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@]4(C)[C@H]3CC[C@]12C,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120219522A1,O=[N+]([O-])c1ccc(Oc2ccnc3cc(OCc4ccccc4)ccc23)cc1>>O=[N+]([O-])c1ccc(Oc2ccnc3cc(O)ccc23)cc1,,C1COCCO1,,Cl,,val
US20100222345A1,Cl.O=C([O-])n1cnc2cc(-c3cccc(CNCC4CCCCC4)c3)ccc21>>Cl.c1cc(CNCC2CCCCC2)cc(-c2ccc3[nH]cnc3c2)c1,,C1COCCO1,,,,val
US20120270938A1,COCOc1c(C)cc(/C=C/c2cccc(C(=O)Sc3ccccc3)c2)cc1C>>Cc1cc(/C=C/c2cccc(C(=O)Sc3ccccc3)c2)cc(C)c1O,,C1CCOC1,CC(C)O,Cl,,val
US20030078251A1,COC(=O)COc1ccc(NC(=O)C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)COC(C)=O)C2=O)c(F)c1>>COc1cccc([C@H]2O[C@H](CC(=O)Nc3ccc(OCC(=O)O)cc3F)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,O,,CCO,[Na+].[OH-],val
US20140309208A1,CCOC(=O)c1c(CBr)cccc1OC.CN>>COc1cccc2c1C(=O)N(C)C2,,CO,,,,val
US20050234109A1,O=S(=O)(Cc1cc(F)ccc1F)c1ccc(Cl)cc1.OC1CCOCC1>>O=S(=O)(c1ccc(Cl)cc1)C(c1cc(F)ccc1F)C1CCOCC1,,CCCCCC,Cc1ccccc1,CCCCP(=CC#N)(CCCC)CCCC,,val
US07288537B2,CCc1nnc(NC(=O)Oc2ccccc2)s1.C[C@@H](N)CCN1CC(Oc2ccc(Cl)cc2)C1>>CCc1nnc(NC(=O)N[C@H](C)CCN2CC(Oc3ccc(Cl)cc3)C2)s1,,CS(C)=O,,,,val
US20150011548A1,CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4c[nH]nn4)cnc32)c1.c1ccncc1>>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4c[nH]nn4)ccc32)c1,,ClCCl,,,,val
US20040259923A1,C=O.CC(=O)Nc1nc(/C=C\c2ccc([N+](=O)[O-])cc2)cs1.CNC>>CC(=O)Nc1nc(/C=C\c2ccc([N+](=O)[O-])cc2)c(CN(C)C)s1,,CC(=O)O,,Cl,,val
US20120010190A1,CS(=O)(=O)Cl.Cc1cc(Cl)ccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(N)cc1>>Cc1cc(Cl)ccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(NS(C)(=O)=O)cc1,,c1ccncc1,,,,val
US20060025474A1,CCC(CC)(c1cccc(C)c1)c1ccc(O)c(C)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCC(CC)(c1cccc(C)c1)c1ccc(OS(=O)(=O)C(F)(F)F)c(C)c1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2c(OC)cccc23)cc1.Nc1ccc(N2CCSCC2)cc1>>COc1cccc2c1nc(Nc1ccc(N3CCSCC3)cc1)c1n[nH]cc12,C1COCCO1,CO,,Cl,,val
US20040242884A1,CNCC(O)c1ccc(O)cc1.Cc1c(CCl)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12>>Cc1c(CN(C)CC(O)c2ccc(O)cc2)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20100041684A1,CSc1nccc(Cl)n1.O=[N+]([O-])c1ccc(O)cc1Cl>>CSc1nccc(Oc2ccc([N+](=O)[O-])c(Cl)c2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20140038923A1,CC(=O)C(C)(C)C.CCOC(=O)C(=O)OCC.CS(=O)(=O)c1ccc(NN)cc1>>CCOC(=O)c1cc(C(C)(C)C)n(-c2ccc(S(C)(=O)=O)cc2)n1,,C1CCOC1,CCO,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20140179680A1,CI.C[C@H]1CC[C@H](Cn2c(N3CCO[C@@H]4CCC[C@H]43)nc3c(O)c(C#N)nc(-c4cncc(Cl)c4)c32)CC1>>COc1c(C#N)nc(-c2cncc(Cl)c2)c2c1nc(N1CCO[C@@H]3CCC[C@H]31)n2C[C@H]1CC[C@H](C)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04216218,CN1CCC(O)C(c2ccccc2)C1.Fc1ccc(Cl)cc1>>CN1CC[C@@H](Oc2ccc(Cl)cc2)[C@H](c2ccccc2)C1,,ClCCl,c1ccccc1,CN(C)C=O,[H-].[Na+],val
US20130096113A1,COc1cc(N)c([N+](=O)[O-])cc1Br.CSc1nc2ccc(CCl)cc2s1>>COc1cc(NCc2ccc3nc(SC)sc3c2)c([N+](=O)[O-])cc1Br,,CN(C)C=O,,[H-].[Na+],,val
US20150183804A1,Clc1ncc(Br)cn1.OCC1CC1>>Brc1cnc(OCC2CC2)nc1,,C1CCOC1,O,[H-].[Na+],,val
US04602041,N=C(N)NC(=O)Cc1c(Cl)cccc1Cl.O=[N+]([O-])O>>N=C(N)NC(=O)Cc1c(Cl)ccc([N+](=O)[O-])c1Cl,,Cl,,O=S(=O)(O)O,[Na+].[OH-],val
US20100273764A1,CSc1ccc(C(C)(O)c2ccc(F)nc2)cc1>>C=C(c1ccc(SC)cc1)c1ccc(F)nc1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20150291595A1,Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(Br)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12.Cc1nnc(-c2cccc(B3OC(C)(C)C(C)(C)O3)c2)o1>>Cc1nnc(-c2cccc(-c3cn(COCC[Si](C)(C)C)c4ncnc(N[C@@H](C)c5nn6ccc(C)c6c(=O)n5-c5ccccc5)c34)c2)o1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20030212092A1,CC[C@@H](N)CO.O=[N+]([O-])c1cnc2ccccc2c1Cl>>CC[C@H](CO)Nc1c([N+](=O)[O-])cnc2ccccc12,,ClCCl,,CCN(CC)CC,,val
US20160130229A1,N#CCC(N)=S.O=C(CC(=O)C(F)(F)F)c1cccs1>>N#Cc1c(C(F)(F)F)cc(-c2cccs2)nc1S,,CCO,O,CCN(CC)CC,,val
US08143463B2,C1CCOC1.C1COCN1.CC(Br)Br.CCCCCCCBr.Cc1ccccc1>>CCCCCCCC1COCCN1CCO,II,Cc1ccccc1,,Cl,[Mg],val
US20110269745A1,CO.N#Cc1ccc(-c2csc(NCC3CC3)n2)nc1.NCc1ccc(-c2csc(NCC3CC3)n2)nc1>>C=C(OCC)c1ccc(C#N)cn1,[Ni],,,N,[H][H],val
US20130053364A1,CCOC(=O)c1c(CS(=O)(=O)c2ccccc2)ccc(-c2ccnn2C2CCCCO2)c1OC>>CCOC(=O)c1c(CS(=O)(=O)c2ccccc2)ccc(-c2cc[nH]n2)c1OC,,CO,,CC(=O)Cl,,val
US04719302,CC(=O)Nc1cc(N)ccc1F.CCOC=C(C(=O)OCC)C(=O)OCC>>CCOC(=O)C(=CNc1ccc(F)c(NC(C)=O)c1)C(=O)OCC,,Cc1ccccc1,,,,val
US20050267149A1,CCCCCCCN(CCc1ccccc1OC)C(=O)Cc1ccc(OCc2ccccc2C(=O)OC)cc1>>CCCCCCCN(CCc1ccccc1OC)C(=O)Cc1ccc(OCc2ccccc2C(=O)O)cc1,,CCO,,[K+].[OH-],,val
US20060142585A1,F[C@H]1CCNC1.O=C(Cl)CCl>>O=C(CCl)N1CC[C@H](F)C1,,ClCCl,O,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US20150322076A1,CC(C)(C#N)C[C@@H]1N[C@@H](C(=O)O)[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12.COC(=O)c1ccc(N)cc1>>COC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C#N)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030225152A1,CCN(CC)CCCO.O=[N+]([O-])c1ccc(F)cc1>>CCN(CC)CCCOc1ccc([N+](=O)[O-])cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20110046169A1,C[Sn](C)(C)C.Cc1c(Br)cc(C#N)c(=O)n1-c1ccc(F)cc1>>Cc1cc(C#N)c(=O)n(-c2ccc(F)cc2)c1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,CCOC(C)=O,O,val
US20070142446A1,COc1cccc2c(C(N)=S)cn(CC3CCCCC3)c12.O=C(CCl)CCl>>COc1cccc2c(-c3nc(CCl)cs3)cn(CC3CCCCC3)c12,,CCO,,,,val
US20090137609A1,CCC(CC)(c1ccc(/C=C/C(O[Si](C)(C)C(C)(C)C)(C(F)(F)F)C(F)(F)F)c(C)c1)c1ccc(B2OC(C)(C)C(C)(C)O2)c(C)c1.CCOC(=O)Cc1cnc(Br)nc1>>CCOC(=O)Cc1cnc(-c2ccc(C(CC)(CC)c3ccc(/C=C/C(O)(C(F)(F)F)C(F)(F)F)c(C)c3)cc2C)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20080214545A1,CCOC(C)=O.COCCOc1ccc(-n2nc(C(C)(C)C)cc2N)cc1.Nc1ccc(Oc2ccncc2)cc1>>COCCOc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccncc3)cc2)cc1,,ClCCCl,,,,val
US20060089392A1,COC(=O)c1cc(I)c(O)c(OC)c1.COCCl>>COCOc1c(I)cc(C(=O)OC)cc1OC,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20140235620A1,CC(=O)C(C)(C)NC(=O)OC(C)(C)C>>CC(O)C(C)(C)NC(=O)OC(C)(C)C,,CO,,[BH4-].[Na+],,val
US20040077704A1,CCc1c(C(=O)C(N)=O)c2c(OCC(=O)OC)cc3c(c2n1Cc1ccccc1)CCC3>>CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc3c(c2n1Cc1ccccc1)CCC3,,C1CCOC1,CO,[Li+].[OH-],,val
US20090042890A1,CCOC(=O)c1nc(NC[C@H]2CCCN2)nc2c1[nH]c(=O)n2-c1ccccc1OC.CCOC(=O)c1nc(NC[C@H]2CCCN2C(=O)OC(C)(C)C)nc2c1[nH]c(=O)n2-c1ccccc1OC>>COc1ccccc1-n1c(=O)[nH]c2c(C(N)=O)nc(NC[C@H]3CCCN3)nc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120232051A1,CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1Br.OB(O)c1ccc(F)cc1F>>CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1-c1ccc(F)cc1F,,CN(C)C=O,,,,val
US20050153979A1,CCc1[nH]c2cc(F)ccc2c1C1=CCN(Cc2ccccc2)CC1>>CCc1[nH]c2cc(F)ccc2c1C1CCNCC1,[Pd],CO,,,,val
US20100009986A1,OB(O)c1ccncc1.OCCc1c[nH]c2ccc(Br)cc12>>OCCc1c[nH]c2ccc(-c3ccncc3)cc12,,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20080139586A1,CC(C)(C)[Si](OCC(F)CO)(c1ccccc1)c1ccccc1>>CC(C)(C)[Si](OCC(F)C=O)(c1ccccc1)c1ccccc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US06028076,COC(=O)Cl.Nc1ncnc2c1nc(O)n2Cc1ccccc1>>COC(=O)Oc1nc2c(N)ncnc2n1Cc1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US05707547,CCCCCCCCOc1cnc(-c2ccc(/C=C/CCCC(C)O)cc2)nc1.CCI>>CCCCCCCCOc1cnc(-c2ccc(/C=C/CCCC(C)OCC)cc2)nc1,O=[Ag],ClC(Cl)Cl,,,,val
US07151112B1,COC(=O)CS.O=C(Nc1ccc(F)cc1)c1ccc(Cl)nc1>>COC(=O)CSc1ccc(C(=O)Nc2ccc(F)cc2)cn1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20070060754A1,CCc1nc2cnc3cc(OCC(=O)N4CCOCC4)ccc3c2n1CC(C)C.O=C(OO)c1cccc(Cl)c1>>CCc1nc2c[n+]([O-])c3cc(OCC(=O)N4CCOCC4)ccc3c2n1CC(C)C,,ClC(Cl)Cl,,,,val
US20070167433A1,COCCCN1CCOc2ccc(COC3CN(S(=O)(=O)c4ccc(C)cc4)CC(O)C3c3ccc(OC4CCN(c5cccc(F)c5)C4)cc3)cc21.Cc1ccc(S(=O)(=O)OCCN(C)S(=O)(=O)c2ccc(C)cc2)cc1>>COCCCN1CCOc2ccc(COC3CN(S(=O)(=O)c4ccc(C)cc4)CC(OCCN(C)S(=O)(=O)c4ccc(C)cc4)C3c3ccc(OC4CCN(c5cccc(F)c5)C4)cc3)cc21,,C1CCOC1,COC(C)(C)C,[H-].[Na+],,val
US20150175623A1,O=C(OC(=O)C(F)F)C(F)F.OCCN1CCNCC1>>O=C(C(F)F)N1CCN(CCO)CC1,CN(C)c1ccncc1,,,CCO,,val
US20090036450A1,Cc1nc(COC(c2ccccc2)(c2ccccc2)c2ccccc2)oc1CN1C(=O)c2ccccc2C1=O>>Cc1nc(COC(c2ccccc2)(c2ccccc2)c2ccccc2)oc1CN,,CCO,,NN,O,val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2cc(F)c(O[C@H]3CCC[C@@H]3c3ccnn3C)cc2Cl)c(OC)c1>>Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(Cl)c(S(=O)(=O)Nc2ccncn2)cc1F,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20070225275A1,CC(=O)c1ccc(Nc2nc(C(C)C)nc3c2CCN(c2ncccc2C(F)(F)F)CC3)cc1>>CC(C)c1nc2c(c(Nc3ccc(C(C)O)cc3)n1)CCN(c1ncccc1C(F)(F)F)CC2,,CO,,[BH4-].[Na+],,val
US20040009526A1,O=C1CSC(=O)N1.O=Cc1ccc(-c2cncc(C(=O)NCCCO)c2)o1>>O=C1NC(=O)C(=Cc2ccc(-c3cncc(C(=O)NCCCO)c3)o2)S1,C1CCNCC1,CCO,,,,val
US20020072517A1,COCCBr.O=S(=O)(O)Cl.Oc1ccccc1>>COCCOc1ccc(S(=O)(=O)Cl)cc1,,CS(C)=O,ClCCl,[K+].[OH-],,val
US20070281920A1,C=O.c1ccc2c(c1)CNCCC2c1ccc2[nH]ccc2c1>>CN1CCC(c2ccc3[nH]ccc3c2)c2ccccc2C1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20130085127A1,N#Cc1cc(CO)ccn1.O=S(Cl)Cl>>N#Cc1cc(CCl)ccn1,,Cc1ccccc1,,,,val
US20080096914A1,CC(C)(C)OC(=O)N1CCc2c(sc(NC(=O)CCc3ccco3)c2C#N)C1>>N#Cc1c(NC(=O)CCc2ccco2)sc2c1CCNC2,,ClCCl,O=C(O)C(F)(F)F,,,val
US05266283,CC(C)(C)c1ccc(O)cc1.CCC(C)(C)O>>CCC(C)(C)c1cc(C(C)(C)C)ccc1O,,O=C(O)C(F)(F)F,,[Na+].[OH-],,val
US20030149001A1,Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)C(C)(C)C4)cn3)ncc12.Cl>>Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(N4CCNC(C)(C)C4)cn3)ncc12.Cl,,Cl,,ClCCl,,val
US20050244332A1,CC1(C)C=Cc2cc(Br)ccc2O1.COc1cc(CC=O)cc(OC)c1OCc1ccccc1>>COc1cc(CC(=O)c2ccc3c(c2)C=CC(C)(C)O3)cc(OC)c1OCc1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20030171428A1,COc1cc(Br)c(OC)c(CCl)c1.[C-]#N>>COc1cc(Br)c(OC)c(CC#N)c1,,CS(C)=O,,O,,val
US05955464,Clc1ncnc2ccc(-n3ccnc3)cc12.Nc1ccc(F)c(Cl)c1>>Fc1ccc(Nc2ncnc3ccc(-n4ccnc4)cc23)cc1Cl,,CC(C)O,O,[NH4+].[OH-],,val
US20040167183A1,Cc1ccc(S(=O)(=O)NCCc2ccc([N+](=O)[O-])cc2)cc1.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>Cc1ccc(S(=O)(=O)N(CCc2ccc([N+](=O)[O-])cc2)C(=O)c2ccc([N+](=O)[O-])cc2)cc1,,C1CCOC1,,[H-].[Na+],,val
US20160068489A1,Cc1nc(NC(=O)CC(C)C)c(C)c(C)c1OCc1ccccc1>>Cc1nc(NC(=O)CC(C)C)c(C)c(C)c1O,[Pd],,,CO,,val
US20080004309A1,CCOC(=O)c1nc(Br)c2c(c1O)c1ccccc1n2C.C[Sn](C)(C)C>>CCOC(=O)c1nc(C)c2c(c1O)c1ccccc1n2C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US05616774,C1CCNCC1.CC(C)(C)c1cccc(C(C)(C)C)c1O.O=Cc1ccc([N+](=O)[O-])cc1>>CC(C)(C)c1cc(C(c2ccc([N+](=O)[O-])cc2)N2CCCCC2)cc(C(C)(C)C)c1O,,CCCCO,,,,val
US20120202785A1,C[C@H](NC(=O)OC(C)(C)C)c1nc2ccc(F)c(C(=O)N3CCOCC3)c2n1C1CC1>>C[C@H](N)c1nc2ccc(F)c(C(=O)N3CCOCC3)c2n1C1CC1,,CO,ClCCl,O=C(O)C(F)(F)F,,val
US20060040961A1,Brc1ncnc2oc(-c3ccccc3)c(-c3ccccc3)c12.CNC1SCCS1>>c1ccc(-c2oc3ncnc(NCC4SCCS4)c3c2-c2ccccc2)cc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20160272596A1,COC(=O)c1ccc2c(CN3C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)CNc4ccccc43)c(OC)ccc2c1.O=C(O)CCCNC(=O)OCC1c2ccccc2-c2ccccc21>>COC(=O)c1ccc2c(CN3C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)CN(C(=O)CCCNC(=O)OCC4c5ccccc5-c5ccccc54)c4ccccc43)c(OC)ccc2c1,,c1ccncc1,,O=P(Cl)(Cl)Cl,,val
US20100113391A1,CCOC(=O)CCC(=O)Cl.Nn1c(=O)c2cc(F)c(NC3CCCCC3)cc2n(C2CCCC2)c1=O>>CCOC(=O)CCC(=O)Nn1c(=O)c2cc(F)c(NC3CCCCC3)cc2n(C2CCCC2)c1=O,,c1ccncc1,,,,val
US04677190,O=C(c1ccccc1)c1ccccc1>>CCCCCC(=O)CC,,C1CCOC1,,CC(=O)OC(C)=O,,val
US05719141,COC(=O)[C@H](C[C@H](C)CCO[Si](C(C)C)(C(C)C)C(C)C)NC(=O)OC(C)(C)C>>CC(C)[Si](OCC[C@@H](C)C[C@@H](C=O)NC(=O)OC(C)(C)C)(C(C)C)C(C)C,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US06498172B1,COC(=O)CCc1cccc(CNCc2ccc3c(c2)CCO3)c1.CS(=O)(=O)Cl>>COC(=O)CCc1cccc(CN(Cc2ccc3c(c2)CCO3)S(C)(=O)=O)c1,,CCN(CC)CC,,,,val
US20110112058A1,O=C(CCl)Nc1ccc(-n2nc(C3CC3)cc2C2CC2)cc1.c1ccc2[nH]cnc2c1>>O=C(Cn1cnc2ccccc21)Nc1ccc(-n2nc(C3CC3)cc2C2CC2)cc1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20160257682A1,CC(C)(O)C1CNC1.CC(C)n1nc(I)c2cnc(Cl)cc21.O=C(O)[C@@H]1CCCN1>>CCC(C)n1nc(N2CC(C(C)(C)O)C2)c2cnc(Cl)cc21,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070060607A1,CCOC(=O)c1cnc(Cl)c2c(CBr)csc12.Cc1ccc(NC(=O)c2ccccc2)cc1O>>CCOC(=O)c1cnc(Cl)c2c(COc3cc(NC(=O)c4ccccc4)ccc3C)csc12,,C1CCOC1,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20120264737A1,CCC(=N)N.Cc1cc(C2CCC2)c(C(=O)CBr)cc1C(=O)N1CCC(c2ccc(C#N)cc2)CC1>>CCc1ncc(-c2cc(C(=O)N3CCC(c4ccc(C#N)cc4)CC3)c(C)cc2C2CCC2)[nH]1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20030139473A1,COC(=O)Cc1ccc(O)cc1.OC/C=C/Cc1ccc(-c2ccc(Br)cc2)cc1>>COC(=O)Cc1ccc(OC/C=C(\C)c2ccc(-c3ccc(Br)cc3)cc2)cc1,,C1CCOC1,,CCCCP(CCCC)CCCC,,val
US20090186870A1,C1CNCCN1.C=CS(=O)(=O)c1ccc2nc(N)sc2c1.NC(=O)c1cc(-n2cccc2)ccc1Cl.O=C(Cl)C(=O)Cl>>O=C(NC(=O)c1cc(-n2cccc2)ccc1Cl)Nc1nc2ccc(S(=O)(=O)CCN3CCNCC3)cc2s1,,C1CCOC1,,,,val
US04638067,CCOC(=O)N1CCN(c2nc(N(C(C)=O)C3CC3)ccc2[N+]#N)CC1.F[B-](F)(F)F>>CCOC(=O)N1CCN(c2nc(N(C(C)=O)C3CC3)ccc2F)CC1,,Cc1ccccc1,,,,val
US20100087427A1,CC(C)c1cccc(C[C@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN(Cc2ccccc2)c2ccc(Cl)cc2)c1>>CC(C)c1cccc(C[C@H]2CNC[C@@H]2CN(Cc2ccccc2)c2ccc(Cl)cc2)c1,,C1COCCO1,Cl,,,val
US20120053147A1,Cc1c(Cl)cccc1CNc1nc(N2CCOCC2)sc1C(N)=O.O=C(Cl)CSc1ccccc1>>Cc1c(Cl)cccc1Cn1c(CSc2ccccc2)nc(=O)c2sc(N3CCOCC3)nc21,,C1CCOC1,,,,val
US20110224262A1,COc1cccc(C(C(=O)c2ccccc2)=C(SC)SC)c1.NN>>COc1cccc(-c2c(-c3ccccc3)n[nH]c2SC)c1,,CCO,,O,,val
US20020198248A1,CS(=O)(=O)Cl.O=C(O)C(O)c1ccccc1.Oc1cccc(O)c1>>O=c1c(-c2ccc(O)cc2)coc2cc(O)ccc12,,CCCCCC,CCOCC,FB(F)F,,val
US06150524,COCOc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341.COc1ccc(CCCC(=O)O)cc1>>COCOc1ccc2c3c1O[C@H]1[C@@H](OC(=O)CCCc4ccc(OC)cc4)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US03932472,CCCCCC(CCI)OC(C)(C)C.CCOC(=O)CCCCCCC1=CCCC1=O>>CCCCCC(CC[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)OCC)OC(C)(C)C,,CCOCC,O,[Mg],[Cl-].[NH4+],val
US20090018103A1,COCCCC[C@@](O)(c1cccc(Cl)c1F)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1>>COCCCC[C@@](O)(c1cccc(Cl)c1F)[C@@H]1CCCNC1,,ClCCl,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],,val
US20010027196A1,Nc1nc(OS(=O)(=O)C(F)(F)F)c([N+](=O)[O-])c(-c2ccco2)n1.OCCc1ccccc1>>Nc1nc(OCCc2ccccc2)c([N+](=O)[O-])c(-c2ccco2)n1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20130029987A1,O[C@H]1CCC[C@@H](N(Cc2ccccc2)Cc2ccccc2)C1>>O=C1CCC[C@@H](N(Cc2ccccc2)Cc2ccccc2)C1,,ClCCl,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US05405861,CC(Br)C(=O)Cl.Fc1cccc(F)c1>>CC(Br)C(=O)c1ccc(F)cc1F,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100029737A1,COC(=O)c1cc2c([nH]1)CCC2Cc1ccc(F)cc1F>>O=C(O)c1cc2c([nH]1)CCC2Cc1ccc(F)cc1F,,C1CCOC1,,CO,[Li+].[OH-],val
US20070244092A1,CCC(C)(C)c1nc2cc(S(=O)(=O)n3cc(C(=O)O)cn3)ccc2n1CC1CCOCC1.NC1CC1>>CCC(C)(C)c1nc2cc(S(=O)(=O)n3cc(C(=O)NC4CC4)cn3)ccc2n1CC1CCOCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110190300A1,CC(C)(C)OC(=O)C(O)c1cccc(C#N)c1.O=C1c2ccccc2C(=O)N1O>>CC(C)(C)OC(=O)C(ON1C(=O)c2ccccc2C1=O)c1cccc(C#N)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04764522,NCCO.O=C(Cl)c1ccccn1>>O=C(NCCO)c1ccccn1,,CN(C)C=O,,,,val
US05866684,Cc1ccccc1C[C@H](NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)CCC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)OCc1ccccc1)C(C)(C)C>>Cc1ccccc1C[C@H](NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)CCC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C,[Pd],CN(C)C=O,,,,val
US20150315187A1,Cn1c(N2CCC(NC(=O)OC(C)(C)C)CC2)nc(-c2ccc(C#N)c(F)c2)c(Cl)c1=O.OB(O)c1ccc2occc2c1>>Cn1c(N2CCC(NC(=O)OC(C)(C)C)CC2)nc(-c2ccc(C#N)c(F)c2)c(-c2ccc3coccc2-3)c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US05071999,C=CCN(CC=O)C(=O)OCC.CC1(C)SCNC1C(=O)O>>CCOC(=O)N1CC2CC3N(CSC3(C)C)C2C1,,Cc1ccccc1,,,,val
US06479495B1,COc1cc(C=O)ccc1OC(=O)N(C)C.COc1cc2c(cc1OC)CNCC2>>COc1cc2c(cc1OC)CN(Cc1ccc(OC(=O)N(C)C)c(OC)c1)CC2,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110136763A1,COc1ccc(OC)c(CNc2nccc(Oc3cc(C)c4c(c3)B(O)OC4CC(=O)O)n2)c1.O=C(O)C(F)(F)F>>Cc1cc(Oc2ccnc(N)n2)cc2c1C(CC(=O)O)OB2O.O=CO,,ClCCl,,,,val
US20120184543A1,CCI.CC[C@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CCCC1>>CCC1(CC)C(=O)N(C)c2cnc(Cl)nc2N1C1CCCC1,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20100069347A1,CCOC(=O)c1n[nH]c(I)n1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)c1nc(I)nn1C(c1ccccc1)(c1ccccc1)c1ccccc1,,O,,CCN(CC)CC,CN(C)C=O,val
US20130184284A1,CC(C)(C)OC(=O)N[C@@H]1CCCC[C@H]1N.CS(=O)(=O)OC1CCCN(c2ccc(-c3ncco3)cc2)C1>>CC(C)(C)OC(=O)N[C@@H]1CCCC[C@H]1NC1CCCN(c2ccc(-c3ncco3)cc2)C1,,CC#N,,,,val
US20080188458A1,COc1ccc2c(c1)CC(C(=O)O)Cn1c-2c(C2CCCCC2)c2ccc(C(=O)NS(=O)(=O)N(C)C)cc21.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COc1ccc2c(c1)CC(C(=O)N=[N+]=[N-])Cn1c-2c(C2CCCCC2)c2ccc(C(=O)NS(=O)(=O)N(C)C)cc21,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US20150191502A1,COc1ccc(C(=O)c2cc(I)ccc2Cl)cc1>>COc1ccc(Cc2cc(I)ccc2Cl)cc1,,CC#N,,CC[SiH](CC)CC,,val
US20100249123A1,COc1ccc(C(=O)Cl)cc1OC.N#CC1(c2ccc(N)cc2)CCCC1>>COc1ccc(C(=O)Nc2ccc(C3(C#N)CCCC3)cc2)cc1OC,,ClCCl,,CCN(CC)CC,,val
US20050014753A1,CCOC(=O)c1ccc(-c2ncnc(Nc3ccc(OC(F)(F)F)cc3)n2)cc1>>O=C(O)c1ccc(-c2ncnc(Nc3ccc(OC(F)(F)F)cc3)n2)cc1,,CC#N,O,Cl,[Na+].[OH-],val
US20010056107A1,COc1ccc(C(=O)c2cccc([N+](=O)[O-])c2)cc1OC>>COc1ccc(C(=O)c2cccc(N)c2)cc1OC,[Pd],CCOC(C)=O,,[H][H],,val
US20100120785A1,Cn1cc(CN2CCN(c3nccnc3Cl)CC2)cn1.OB(O)c1ccc(F)c(Cl)c1>>Cn1cc(CN2CCN(c3nccnc3-c3ccc(F)c(Cl)c3)CC2)cn1,,CC(=O)N(C)C,O,O=C([O-])[O-].[K+].[K+],,val
US20040127574A1,COC(=O)C1(C)CCCc2ccccc2C1=O>>CC1CCCc2ccccc2C1=O,,CC(=O)O,,Cl,,val
US20150291632A1,CCc1cc(C=O)ccc1Br>>CCc1cc(CO)ccc1Br,,C1CCOC1,,[BH4-].[Na+],,val
US04837316,CCOC(=O)CSCc1ccco1.CO>>CCOC(=O)CS(=O)Cc1ccco1,,CO,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20110002855A1,CCOC(=O)N1CCc2c(sc3nc[nH]c(=O)c23)C1.O=P(Cl)(Cl)Cl>>CCOC(=O)N1CCc2c(sc3ncnc(Cl)c23)C1,,c1ccncc1,,,,val
US20150361059A1,CC(C)(C)OC(=O)N[C@@H](CSc1c([N+](=O)[O-])cccc1[N+](=O)[O-])C(=O)O>>CC(C)(C)OC(=O)N[C@@H](CSc1c(N)cccc1N)C(=O)O,[Zn],CO,O,[Cl-].[NH4+],,val
US20140011819A1,CC(Br)c1oc2ccc(F)cc2c(=O)c1-c1cccc(F)c1.CCCCO>>CC(O)c1oc2ccc(F)cc2c(=O)c1-c1cccc(F)c1,,CCCCO,,CS(C)=O,,val
US20120004262A1,Cc1noc(CN(C(=O)OC(C)(C)C)[C@H]2C[C@H]2c2ccccc2)n1.Cl>>Cc1noc(CN[C@@H]2C[C@H]2c2ccccc2)n1.Cl,,CCOCC,,,,val
US20120071514A1,CCS(=O)(=O)Nc1cncc(Br)c1.Cn1c(=O)oc2cc(F)c(B3OC(C)(C)C(C)(C)O3)cc21>>CCS(=O)(=O)Nc1cncc(-c2cc3c(cc2F)oc(=O)n3C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20090054508A1,CSc1ccccc1CO>>CSc1ccccc1C=O,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20030225152A1,CN1CCNCC1.O=C1Nc2ccccc2C1=CNc1ccc(OCCCI)cc1>>CN1CCN(CCCOc2ccc(NC=C3C(=O)Nc4ccccc43)cc2)CC1,,C1CCOC1,,CCOC(C)=O,,val
US20040077669A1,C#CCO.Cc1nc(Cl)cc(-c2ccccc2)n1>>C#CCOc1cc(-c2ccccc2)nc(C)n1,,CN(C)C=O,,O,[H-].[Na+],val
US20100210651A1,CCCCc1noc(C)c1C(=O)OCC>>CCCCc1noc(C)c1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090036445A1,CC(C)CNc1nc(-c2c[nH]nc2-c2ccc(F)cc2)ccc1[N+](=O)[O-].ClCCN1CCOCC1>>CC(C)CNc1nc(-c2c(-c3ccc(F)cc3)n[nH]c2C(C)N2CCOCC2)ccc1[N+](=O)[O-],,CN(C)C=O,,Cl,[H-].[Na+],val
US20080139547A1,COC(=O)c1ccc(C#CCNC(=O)c2cc3ccccc3s2)cc1.NO>>O=C(NO)c1ccc(C#CCNC(=O)c2cc3ccccc3s2)cc1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US04064277,O=[N+]([O-])c1ccc(OC2OC(CO)C(O)C(O)C2O)cc1>>O=[N+]([O-])c1ccc(O)cc1,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20020107255A1,C[C@H]1CN(C(=O)COc2ccc(Cl)cc2C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)[C@H](C)CN1Cc1ccc(F)cc1>>C[C@H]1CN(C(=O)COc2ccc(Cl)cc2C(=O)N2CCNCC2)[C@H](C)CN1Cc1ccc(F)cc1,,CC(Cl)Cl,ClCCl,O=C(O)C(F)(F)F,,val
US20080293743A1,CN(C)C=O.COc1cc(C)c(Br)cn1>>COc1nccc(C)c1C=O,,C1CCOC1,,[Li]CCCC,,val
US20150299188A1,Cc1ncc(Cl)c(C=O)c1N.Nc1cc2c(cc1Cl)CCC(c1ncccc1F)O2>>Cc1ncc(Cl)c(CNc2cc3c(cc2Cl)CCC(c2ncccc2F)O3)c1N,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120245137A1,CC1(CO)CCC(F)(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1.CS(=O)(=O)Cl>>CC1(COS(C)(=O)=O)CCC(F)(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1,,C1CCOC1,,,,val
US20080312085A1,OCCNC(=S)NC(Cc1cccs1)c1ccccc1>>c1ccc(C(Cc2cccs2)NC2=NCCS2)cc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100120858A1,COc1cccc(F)c1O.O=Cc1ccc(Cl)cc1F>>COc1cccc(F)c1Oc1cc(Cl)ccc1C=O,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05206240,Cl.O=C1CC2(CCN(C(=O)c3ccccc3)CC2)Sc2sc([N+](=O)[O-])cc21>>Cl.O=C1CC2(CCNCC2)Sc2sc([N+](=O)[O-])cc21,,CO,,,,val
US04933355,C1CSCCN1.CCOC(=O)c1csc(Br)n1>>CCOC(=O)c1csc(N2CCSCC2)n1,,CN(C)C=O,,CCN(CC)CC,,val
US20080242666A1,N#Cc1ccc(-n2ccnn2)cc1>>NCc1ccc(-n2ccnn2)cc1,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20080269218A1,COCOc1cc(OCOC)c(C(C)C)cc1-c1nnc(S(=O)(=O)CCCN(C)C)n1-c1ccc(OC)cc1>>COc1ccc(-n2c(-c3cc(C(C)C)c(O)cc3O)nnc2S(=O)(=O)CCCN(C)C)cc1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20110098296A1,CN(C)CCO.O=[N+]([O-])c1ccc(F)c(F)c1>>CN(C)CCOc1ccc([N+](=O)[O-])cc1F,,CN(C)C=O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090197870A1,COc1cc(C(C)=O)ccc1O.FC(F)(F)c1ccc(CBr)c(C(F)(F)F)c1>>COc1cc(C(C)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20040053908A1,CNc1ccc(OCc2ccccc2)cc1F.O=C=Nc1ccc(F)cc1>>CN(C(=O)Nc1ccc(F)cc1)c1ccc(OCc2ccccc2)cc1F,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20100190831A1,CC(Cc1cc(F)c(OCc2ccccc2)c(F)c1)C(=O)[O-]>>CC(Cc1cc(F)c(OCc2ccccc2)c(F)c1)C(=O)O,,C1CCOC1,O,CO,[Li+].[OH-],val
US20100227866A1,CS(=O)(=O)NC1CCCCC1N1C(=O)c2ccccc2C(C(=O)NOCc2ncn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)C1c1ccc(Cl)cc1Cl>>CS(=O)(=O)NC1CCCCC1N1C(=O)c2ccccc2C(C(=O)NOCc2nc[nH]n2)C1c1ccc(Cl)cc1Cl,,CO,,Cl,O=C([O-])O.[Na+],val
US20130040933A1,Cc1ccc(S(=O)(=O)n2cc(-c3cncc(N4CCN(C(=O)OC(C)(C)C)C[C@@H]4C(=O)NCC(F)(F)F)n3)c3cc(Cl)cnc32)cc1>>Cc1ccc(S(=O)(=O)n2cc(-c3cncc(N4CCNC[C@@H]4C(=O)NCC(F)(F)F)n3)c3cc(Cl)cnc32)cc1,,CCOC(C)=O,,Cl,,val
US20140288041A1,CCc1c(-c2ccc(N3CCNCC3)nc2)cc(C(=O)NCc2c(C(C)C)cc(C)[nH]c2=O)c(C)c1NC1CCOCC1.CN1CCC(=O)CC1>>CCN(c1cc(-c2ccc(N3CCN(C4CCN(C)CC4)CC3)nc2)cc(C(=O)NCc2c(C(C)C)cc(C)[nH]c2=O)c1C)C1CCOCC1,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150261923A1,O.O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>O.O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,,O,,,,val
US20090221564A1,COc1ccc2cc(C#N)sc2c1>>N#Cc1cc2ccc(O)cc2s1,,ClCCl,,BrB(Br)Br,,val
US20110319430A1,Cc1nn(C)c(Oc2c(F)cc(C#N)cc2F)c1I.OB(O)c1ccc(F)cc1Cl>>Cc1nn(C)c(Oc2c(F)cc(C#N)cc2F)c1-c1ccc(F)cc1Cl,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20090093518A1,COc1ccc(Cn2ccc3cc(F)c(Br)cc3c2=O)cc1.OB(O)c1ccccc1>>COc1ccc(Cn2ccc3cc(F)c(-c4ccccc4)cc3c2=O)cc1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US04035376,C1=COCCC1.CC(O)c1cccc(Br)c1>>CC(OC1CCCCO1)c1cccc(Br)c1,Cl,O,,O=C([O-])O.[Na+],,val
US20060046978A1,COC(=O)C(Cc1ccc(OCCNCC(=O)N2CCCC2C#N)cc1)NC(=O)C(CSC(C)=O)Cc1ccccc1>>N#CC1CCCN1C(=O)CNCCOc1ccc(CC(NC(=O)C(CS)Cc2ccccc2)C(=O)O)cc1,,C1CCOC1,,[Li+].[OH-],,val
US04227000,COc1ccnc(CSCCN)c1OC.O=c1[nH]c(N[N+](=O)[O-])ncc1Cc1cccnc1>>COc1ccnc(CSCCNc2ncc(Cc3cccnc3)c(=O)[nH]2)c1OC,,c1ccncc1,,,,val
US20150239878A1,COc1cc2sc(/C=C/C=C/c3ccc([N+](=O)[O-])cc3)nc2cc1O>>COc1cc2sc(/C=C/C=C/c3ccc(N)cc3)nc2cc1O,[Fe],O,,CCO,[Cl-].[NH4+],val
US05397775,Cc1ccc(S(=O)(=O)OC[C@@H](C)C2(O)CCCC2)cc1.Sc1ccccc1>>CC(CSc1ccccc1)C1(O)CCCC1,,CN(C)C=O,,CCN(CC)CC,O,val
US20070032515A1,CC(=O)Cl.Oc1cc(Br)c2ccccc2c1>>CC(=O)c1c(O)cc(Br)c2ccccc12,,CC(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20140315918A1,CCOc1ncccc1[C@]1(NC(=O)N2CCN(C3CCN(C(=O)OC(C)(C)C)CC3)CC2)C(=O)N(S(=O)(=O)c2ccc(OC)cc2OC)c2ccc(C#N)cc21>>CCOc1ncccc1[C@]1(NC(=O)N2CCN(C3CCNCC3)CC2)C(=O)N(S(=O)(=O)c2ccc(OC)cc2OC)c2ccc(C#N)cc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060110743A1,CCCOc1cc([N+](=O)[O-])ccc1C(=O)OCC>>CCCOc1cc(N)ccc1C(=O)OCC,[Zn],N,,,,val
US20120277217A1,CC(C)(C)CCI.O=Cc1cc(O)ccc1O>>CC(C)(C)CCOc1ccc(O)c(C=O)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070032517A1,CC(=O)Nc1c(C(C)=O)c(=O)n(C)c2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc12>>CC(=O)c1c(N)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2n(C)c1=O,,C1COCCO1,CCOC(C)=O,Cl,,val
US05760288,Cc1ccc(C(=O)O)cc1.O=C(O)c1ccc(C(=O)O)cc1>>O=C=O.O=Cc1ccc(C(=O)O)cc1,[Ru],,,,,val
US20010008903A1,CCOC(=O)c1cc2c3c(ccc2[nH]1)OC[C@H](CO)O3.Cc1ccc(S(=O)(=O)Cl)cc1>>CCOC(=O)c1cc2c3c(ccc2[nH]1)OC[C@@H](COS(=O)(=O)c1ccc(C)cc1)O3,CN(C)c1ccncc1,ClCCl,,,,val
US20140275083A1,C[C@@H](c1ncc(-c2ccc(Cl)cc2)o1)N1C(=O)c2ccccc2C1=O>>C[C@H](N)c1ncc(-c2ccc(Cl)cc2)o1,,CCO,,NN,,val
US04689349,CCC(CCCCC1CCC2CC(=O)CC12)OC.CCC(CCCCC1CCC2CC(=O)CC12)OC>>CCC(CCCCC1CCC2CC(C)(O)CC12)OC,,CCOCC,CCOCC,CC[Mg]Br,,val
US20070265284A1,CC(C)=CCn1c(SC(C)(C)CN)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C.Cl>>CC(C)=CCn1c(SC(C)(C)CN)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C.Cl,,CCOC(C)=O,,,,val
US05929085,COC(=O)C1Cc2ccc([N+](=O)[O-])cc2CN1>>O=[N+]([O-])c1ccc2c(c1)CNC(CO)C2,,C1CCOC1,,CO,Cl,val
US20100249078A1,COC(=O)c1ccc(-c2cnc(C(O)CCc3ccc(Oc4ccccc4)cc3)o2)nc1>>COC(=O)c1ccc(-c2cnc(C(=O)CCc3ccc(Oc4ccccc4)cc3)o2)nc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US04978663,CI.COc1ccc(C2(O)CCCCC2)cn1>>Cn1cc(C2(O)CCCCC2)ccc1=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050070547A1,COc1cc(Nc2ccc(C(F)(F)F)cn2)c2ncc(-c3ncccc3C(F)(F)F)cc2n1>>Oc1cc(Nc2ccc(C(F)(F)F)cn2)c2ncc(-c3ncccc3C(F)(F)F)cc2n1,,Br,CC(=O)O,,,val
US20050107449A1,COC(=O)CCc1ccc(OCC(C)c2sc(-c3ccc(-c4cccnc4)cc3)nc2C(C)C)cc1C>>Cc1cc(OCC(C)c2sc(-c3ccc(-c4cccnc4)cc3)nc2C(C)C)ccc1CCC(=O)O,,C1CCOC1,CCOC(C)=O,Cl,[Na+].[OH-],val
US05136868,COc1cc(-n2nnn(CCOS(C)(=O)=O)c2=O)c(Cl)cc1Cl>>C=Cn1nnn(-c2cc(OC)c(Cl)cc2Cl)c1=O,,CN(C)C=O,,[F-].[K+],,val
US20110152245A1,CC(C)(C)OC(=O)N1CCC(CCc2ccc(NC(=O)Nc3ccc(Cl)cn3)cc2)C1.Cl>>Cl.O=C(Nc1ccc(CCC2CCNC2)cc1)Nc1ccc(Cl)cn1,,C1CCOC1,C1COCCO1,,,val
US04115416,CCCCCCCCCC(Br)C(=O)OCC.Oc1ccc(C2=CCCCCC2)cc1>>CCCCCCCCCC(Oc1ccc(C2=CCCCCC2)cc1)C(=O)OCC,,CCO,,O,[Na],val
US20060094644A1,Brc1ccccn1.O=[N+]([O-])c1ccc(B(O)O)cc1>>O=[N+]([O-])c1ccc(-c2ccccn2)cc1,,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US05273975,BrBr.O=CNC1Cc2ccccc2NC1=O>>O=CNC1Cc2cc(Br)ccc2NC1=O,,CC(=O)O,,O,CC(=O)[O-].[Na+],val
US20040167123A1,CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(N)ccc3N2)c(O)c2cccnc21.O=S(=O)(Cl)CCl>>CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(NS(=O)(=O)CCl)ccc3N2)c(O)c2cccnc21,,c1ccncc1,,,,val
US20060166964A1,COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)C[C@H](O)[C@H](O)c1ccccc1-3>>O=C(O)c1ccc2c(C3CCCCC3)c3n(c2c1)C[C@H](O)[C@H](O)c1ccccc1-3,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20160016948A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.C[Si](C)(C)OS(=O)(=O)C(F)(F)F>>CC(C)(C)OC(=O)N1CC=C(O[Si](C)(C)C)CC1,,Cc1ccccc1,O,CCN(CC)CC,,val
US04288364,CC(C)(C)OC(=O)N[C@H]1CN([C@@H](C(=O)O)c2ccc(OC(=O)OC(C)(C)C)cc2)C1=O.[N-]=[N+]=C(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N[C@H]1CN([C@@H](C(=O)OC(c2ccccc2)c2ccccc2)c2ccc(OC(=O)OC(C)(C)C)cc2)C1=O,,C1COCCO1,CC(=O)O,CO,ClC(Cl)Cl,val
US20150166480A1,CCOC(=O)c1ccc(B(O)O)cc1F.FC(F)(F)C1(CN2CCC(COc3ncc(Br)cn3)CC2)CCC1>>CCOC(=O)c1ccc(-c2cnc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)nc2)cc1F,,O,,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US20120270875A1,Cc1nc(NCCCc2cccc(O)c2)nc(C)c1C(=O)N[C@@H](CNC(=O)c1cccs1)C(=O)O.OC1CCCC1>>Cc1nc(NCCCc2cccc(O)c2)nc(C)c1C(=O)N[C@@H](CNC(=O)c1cccs1)C(=O)OC1CCCC1,,C1COCCO1,CCOC(C)=O,O=S(Cl)Cl,,val
US20090137804A1,CCCN1CCN(c2ccc(N)cc2)CC1.CNc1ncnc(Cl)n1>>CNc1ncnc(Nc2ccc(N3CCN(C(C)C)CC3)cc2)n1,,CCO,,CCN(C(C)C)C(C)C,[I-].[Na+],val
US05639778,CCCN(CCC)C1CCc2c(cc3cc[nH]c3c2Br)C1.CN(C)C=O>>CCCN(CCC)C1CCc2c(cc3c(C=O)c[nH]c3c2Br)C1,,O,,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US04036986,CCC(C)N(Cc1ccc(Cl)cc1)C(=S)Cl.Nc1ccccc1>>CCC(C)N(Cc1ccc(Cl)cc1)C(=S)Nc1ccccc1,,Cc1ccccc1,,,,val
US06156857,C1=CC2CCC1C2.C=C>>C1=CC2CCC1C2.C=C,,Clc1ccccc1Cl,,,,val
US06472435B1,C=CCBr.CC(C)(C)OC(=O)Nc1ccc(N(CCO[Si](C)(C)C(C)(C)C)CCO[Si](C)(C)C(C)(C)C)cc1>>C=CCN(C(=O)OC(C)(C)C)c1ccc(N(CCO[Si](C)(C)C(C)(C)C)CCO[Si](C)(C)C(C)(C)C)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US03989704,CC(C)(C)c1ncc2ccccc2c1-c1ccccc1>>CC(C)(C)C1NCc2ccccc2C1c1ccccc1,O=[Pt],CC(=O)O,,[H][H],,val
US20110257137A1,CC(=O)c1cc(Cl)ccc1[N+](=O)[O-].COC(OC)N(C)C>>CN(C)C=CC(=O)c1cc(Cl)ccc1[N+](=O)[O-],,CN(C)C=O,,,,val
US06326386B1,C=CCN(C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1)C1CCCC1>>CCCN(C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1)C1CCCC1,[Pd],Cc1ccccc1,,,,val
US20040132727A1,COc1cc2nccc(Oc3ccc(N)c(F)c3)c2cc1OC.O=C(N=C=S)c1ccccc1Cl>>COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)c4ccccc4Cl)c(F)c3)c2cc1OC,,Cc1ccccc1,,CCO,,val
US20130158042A1,CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)C(C)(C)C1.O=C(O)C(F)(F)F>>CC1(C)CNCCN1C(=O)OCc1ccccc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04554275,COc1ccc(C#N)c2ccccc12>>N#Cc1ccc(O)c2ccccc12,,c1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20040167123A1,CCS(=O)(=O)Cl.NCc1csc2c1S(=O)(=O)N=C(c1c(O)c3ccccc3n(NCC3CC3)c1=O)N2>>CCS(=O)(=O)NCc1csc2c1S(=O)(=O)N=C(c1c(O)c3ccccc3n(NCC3CC3)c1=O)N2,,CN(C)C=O,,CCN(CC)CC,,val
US20100324092A1,CC(C)(C)N(C(=O)[O-])c1ccc(-c2ccccc2)nc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1>>Nc1ccc(-c2ccccc2)nc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1,,CCOC(C)=O,,C1COCCO1,Cl,val
US20140051679A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN1CCC(Oc2cccc(Br)c2)CC1>>CN1CCC(Oc2cccc(B3OC(C)(C)C(C)(C)O3)c2)CC1,,CN(C)C=O,,CC(=O)[O-].[K+],,val
US05658922,CC(=O)[C@H]1CC[C@H]2[C@@H]3[C@@H](C)C[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@@]21C.C[Mg]Br>>C[C@H]1C[C@H]2NC(=O)C=C[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3C(C)(C)O)[C@H]12,,C1CCOC1,CCOCC,[Cl-].[NH4+],,val
US20080306083A1,C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Nc4ccc(F)cc4)CC3)n2)C[C@@H](C)N1.Cl>>C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Nc4ccc(F)cc4)CC3)n2)C[C@@H](C)N1.Cl,,ClCCl,,CCOCC,,val
US05672712,CC(C)N.N#Cc1ccc(C(=O)N=C=S)cc1>>CC(C)NC(=S)NC(=O)c1ccc(C#N)cc1,,Cc1ccccc1,,,,val
US20160272645A1,C=CC(=O)Cl.Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)cn2CCNCc1ccc(F)cc1>>C=CC(=O)N(CCn1cc(-c2ccc(Cl)c(O)c2)c2c(N)ncnc21)Cc1ccc(F)cc1,,ClCCl,,,,val
US20030004304A1,COCCOCCOCCO.CS(=O)(=O)Cl>>COCCOCCOCCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20060004043A1,CC(C)CC(=O)NN.CCOC(=N)c1ccc2[nH]nc(-c3ccc4cc(OCC5CN(C)CCN5C)ccc4c3)c2c1>>CC(C)Cc1nc(-c2ccc3[nH]nc(-c4ccc5cc(OCC6CN(C)CCN6C)ccc5c4)c3c2)n[nH]1,,CO,,CCN(CC)CC,,val
US20080090818A1,CC(C)(C)OC(=O)N1CCNC(=O)C1.Nc1ccc(I)cc1>>CC(C)(C)OC(=O)N1CCN(c2ccc(N)cc2)C(=O)C1,[Cu]I,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20110021556A1,c1ccc(CN2CCC(Cc3ccccc3)(c3ccc4sccc4c3)C2)cc1>>c1ccc(CC2(c3ccc4sccc4c3)CCNC2)cc1,,ClCCCl,,CC(Cl)OC(=O)Cl,,val
US20080058293A1,C[C@H](CC(=O)Nc1c(Cl)ccc2nc(CCCN(CCCO[Si](C)(C)C(C)(C)C)C(=O)OC(C)(C)C)ccc12)c1ccccc1>>C[C@H](CC(=O)Nc1c(Cl)ccc2nc(CCCNCCCO)ccc12)c1ccccc1,,C1COCCO1,ClCCl,Cl,,val
US20020147334A1,C#CC(CC(=O)OC)Cc1ccc(OC)cc1>>C#CC(CC(=O)OC)Cc1ccc(O)cc1,,ClCCl,,BrB(Br)Br,,val
US20110092505A1,COC(=O)c1ccc(Cl)nc1.C[Sn](C)(C)c1ccnc(NC2CCCCC2)c1>>COC(=O)c1ccc(-c2ccnc(NC3CCCCC3)c2)nc1,,CCOC(C)=O,,Cc1ccccc1,,val
US04049663,CNCC1(N2CCCCC2)CCCCC1.O=C(Cl)c1ccc(Cl)c(Cl)c1>>CN(CC1(N2CCCCC2)CCCCC1)C(=O)c1ccc(Cl)c(Cl)c1.Cl,,c1ccccc1,,,,val
US20050234091A1,Oc1ccnc2ccsc12.[O-]Cl>>Oc1ccnc2c(Cl)csc12,,[Na+],[OH-],CC(=O)O,,val
US03931407,Nc1ccc(O)c(C(=O)O)c1.O=C(CC1CCCCC1=O)c1ccc([N+](=O)[O-])cc1>>O=C(O)c1cc(-n2c(-c3ccc([N+](=O)[O-])cc3)cc3c2CCCC3)ccc1O,,O,,CC(=O)O,,val
US20160221972A1,COc1ccc(CN2CCOc3nc(C(=O)OC(C)C)ccc3C2)cc1.NO>>COc1ccc(CN2CCOc3nc(C(=O)NO)ccc3C2)cc1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20130281431A1,CNC(=O)c1ncnc2c([C@H](C)CNC(=O)C(F)(F)F)cccc12>>CNC(=O)c1ncnc2c([C@H](C)CN)cccc12,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20120136023A1,CO.Cc1nc2sc3c(c2c(I)c1[C@H](OC(C)(C)C)C(=O)O)CCCC3>>COC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2sc3c(c2c1I)CCCC3,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04732998,CCOP(=O)(OCC)C(Oc1ccccc1)P(=O)(OCC)OCC>>O=P(O)(O)C(Oc1ccccc1)P(=O)(O)O,,Cl,,,,val
US20120108589A1,Cc1cn(COCC[Si](C)(C)C)c2nccc(-n3cnc(-c4ccccc4)c3)c12>>Cc1c[nH]c2nccc(-n3cnc(-c4ccccc4)c3)c12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090023725A1,Brc1ccc2c(ccn2-c2ccccn2)c1.Cc1c(F)cc(C(=O)NC2CC2)cc1B(O)O>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(ccn2-c2ccccn2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(C)O,,O=C([O-])O.[Na+],,val
US20080132570A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)OCC(O)COC(=O)c1ccccc1.Cl>>Cl.N[C@@H](Cc1ccc(O)c(O)c1)C(=O)OCC(O)COC(=O)c1ccccc1,,C1COCCO1,,,,val
US04024134,Cc1nnc(SCC2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)[C@@H](NC=O)[C@H]3SC2)s1.O=P(Cl)(Cl)Cl>>Cc1nnc(SCC2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)[C@@H](N)[C@H]3SC2)s1.Cl,,CO,,,,val
US20150133432A1,COCOc1ccc(-c2cc(C(=O)N3CCN(C(=O)OC(C)(C)C)C[C@H]3CC(F)(F)F)c3c(C)nn(C4CCCCO4)c3n2)cc1>>COCOc1ccc(-c2cc(CN3CCN(C(=O)OC(C)(C)C)C[C@H]3CC(F)(F)F)c3c(C)nn(C4CCCCO4)c3n2)cc1,,C1CCOC1,,B,CSC,val
US20130267493A1,CC(C)(C)OC(=O)N1CCN(CCCOc2ccc(Br)cc2)CC1>>Brc1ccc(OCCCN2CCNCC2)cc1,,CCOC(C)=O,,Cl,,val
US04436892,O=C(Cl)c1c(Cl)cccc1Cl.c1ccc(-c2ncc[nH]2)cc1>>O=C(c1c(Cl)cccc1Cl)n1ccnc1-c1ccccc1,,C1CCOC1,,,,val
US20120184542A1,COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(c4ccccc4)C(F)(F)CNC(=O)OC(C)(C)C)ccc3Cl)c(=O)[nH]c2n1>>COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(c4ccccc4)C(F)(F)CN)ccc3Cl)c(=O)[nH]c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090209522A1,CC(C)(C)OC(=O)NCCN.COc1nc(Cl)nc(OC)c1[N+](=O)[O-]>>COc1nc(NCCNC(=O)OC(C)(C)C)nc(OC)c1[N+](=O)[O-],,CCO,,CCN(CC)CC,,val
US05552422,CS(=O)(=O)c1ccc(C(=O)C(Br)c2ccccc2)cc1.Sc1ncc[nH]1>>CS(=O)(=O)c1ccc(-c2c(-c3ccccc3)sc3nccn23)cc1,,CCO,,O,[Na+].[OH-],val
US20050222151A1,C1CCNCC1.ClCc1cc(OCCCN2CCCCC2)no1>>c1c(OCCCN2CCCCC2)noc1CC1CCNCC1,,ClCCl,,,,val
US20060194788A1,CC(C)(C)C1CCCCC1=O.Cc1ccc(S(=O)(=O)Cl)cc1>>CC(C)(C)C1CCCC(Cl)C1=O,,C1CCOC1,,CC(C)NC(C)C,,val
US20060035977A1,CCCCCCCCCCCCCCCC(=S)NCCC(OC(c1ccccc1)(c1ccccc1)c1ccccc1)SC(=S)CCCCCCCCCCCCCCC>>CCCCCCCCCCCCCCCC(=S)NCCC(O)SC(=S)CCCCCCCCCCCCCCC,,CCOCC,Cl,,,val
US20080207608A1,CC1=Nc2ccc(C(F)(F)F)cc2C(=O)C1.O=P(Cl)(Cl)Cl>>Cc1cc(Cl)c2cc(C(F)(F)F)ccc2n1,,C1CCOC1,O,CN(C)C=O,O=C([O-])O.[Na+],val
US20050124664A1,COc1cccc(O)c1C(=O)O.O=S(Cl)Cl>>COc1cccc(O)c1C(=O)Cl,,ClCCl,,CN(C)C=O,,val
US20100168418A1,Cc1cc(=O)n(CCN2CCC(N(Cc3ccc4c(c3)OCCO4)C(=O)OC(C)(C)C)CC2)c2cc(F)ccc12.Cl>>Cc1cc(=O)n(CCN2CCC(NCc3ccc4c(c3)OCCO4)CC2)c2cc(F)ccc12.Cl,,CCOC(C)=O,,CO,,val
US20070129355A1,CNC.COC(=O)Cc1c(Cl)nc(Cc2ccc([N+](=O)[O-])cc2)nc1Cl>>COC(=O)Cc1c(Cl)nc(Cc2ccc([N+](=O)[O-])cc2)nc1N(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20070135415A1,CC(C)(C)OC(=O)N1CCC(CCC(=O)O)CC1.Nc1cc2c3c(c(-c4ccccc4)[nH]c3c1)C=NNC2=O>>CC(C)(C)OC(=O)N1CCC(CCC(=O)Nc2cc3c4c(c(-c5ccccc5)[nH]c4c2)C=NNC3=O)CC1,,CN(C)C=O,ClCCl,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140271460A1,CC(C)[C@@H](CNC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1>>CC(C)[C@H](N)CNC(=O)OC(C)(C)C,[Pd],,,,,val
US20080039452A1,CCOC(=O)CC1(O)CCCCC1.N#Cc1ccccc1.O=S(=O)(O)O>>O=C(O)CC1(NC(=O)c2ccccc2)CCCCC1,,O,,,,val
US20050148604A1,COC(=O)/C=C/c1ccc(-c2nc3c(C)nn(C4CCCCC4)c3c(=O)[nH]2)c(OC)c1>>COc1cc(/C=C/C(=O)O)ccc1-c1nc2c(C)nn(C3CCCCC3)c2c(=O)[nH]1,,O,,CO,[Na+].[OH-],val
US05494928,C[C@@H]1CO1.Fc1cc2cc[nH]c2cc1Cl>>C[C@@H](O)Cn1ccc2cc(F)c(Cl)cc21,,C1CCOC1,CCOCC,O,[H-].[Na+],val
US20120295874A1,CC(C)(C)OC(=O)NCc1ccc(CNC(=O)N2CCN(C(=O)CNC(=O)C(O)CO)CC2)cc1>>NCc1ccc(CNC(=O)N2CCN(C(=O)CNC(=O)C(O)CO)CC2)cc1,,CCOCC,ClCCl,Cl,,val
US20040102450A1,C#CCBr.CC(C)(C)OC(=O)n1c(CN2CCNCC2=O)cc2cnccc21>>C#CCN1CCN(Cc2cc3cnccc3[nH]2)C(=O)C1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04880808,Fc1ccc(Nc2ccc(F)cc2)cc1.O=C(Cl)CCCCl>>O=C(CCCCl)N(c1ccc(F)cc1)c1ccc(F)cc1,,Cc1ccccc1,,,,val
US20150232465A1,C[C@@H](CO)Nc1ncccc1[N+](=O)[O-].O=C1CCC(=O)N1Br>>C[C@@H](CO)Nc1ncc(Br)cc1[N+](=O)[O-],,CC#N,,,,val
US05342846,O=C(O)c1cn(CCF)c2c(F)c(F)c(F)cc2c1=O.c1cn(C2CCNC2)nn1>>O=C(O)c1cn(CCF)c2c(F)c(N3CCC(n4ccnn4)C3)c(F)cc2c1=O,,CC#N,,C1CCC2=NCCCN2CC1,Cl,val
US03987047,CCOC(=O)N1CCc2nc3cccc([N+](=O)[O-])c3c(C)c2CC1>>CCOC(=O)N1CCc2nc3cccc(N)c3c(C)c2CC1,,Cl,,,,val
US04056384,CN(C)N.COC(=O)c1ccccc1N=C=S>>COC(=O)c1ccccc1NC(=S)NN(C)C,,CCO,,,,val
US20100130492A1,CN(C)CCN.Nc1ncc(-c2nc(N3CCOCC3)c3nc(Cl)n(CC4CC4)c3n2)cn1>>CN(C)CCNc1nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc2n1CC1CC1,,CS(C)=O,,,,val
US04638067,CCn1cc(C(=O)O)c(=O)c2cc(F)c(Cl)nc21.NCC1CCN(C2CC2)C1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCC(CNC4CC4)C3)nc21,,CC#N,,,,val
US20080269213A1,BrCc1ccccc1.C=CCc1cc(Cl)c2cccnc2c1O>>C=CCc1cc(Cl)c2cccnc2c1OCc1ccccc1,,CC(C)=O,CCOCC,O=C([O-])[O-].[K+].[K+],,val
US20130281392A1,FC(F)(F)c1nc2cc(Cl)c(I)cc2[nH]1.OB(O)c1ccc(Cl)cc1Cl>>FC(F)(F)c1nc2cc(Cl)c(-c3ccc(Cl)cc3Cl)cc2[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20100004300A1,CC(C)(C)OC(=O)N1CCC(c2cc(Cl)cc(Cl)c2)C1>>Clc1cc(Cl)cc(C2CCNC2)c1,,[Na+],[OH-],C1COCCO1,Cl,val
US20080188528A1,O=S(Cl)Cl.OCc1ccccc1-c1ccc2ccccc2c1>>ClCc1ccccc1-c1ccc2ccccc2c1,,ClCCCl,,,,val
US04908363,CC(C)(C)c1cc(CNn2ccnc2)cc(C(C)(C)C)c1O>>CC(C)(C)c1cc(C=Nn2ccnc2)cc(C(C)(C)C)c1O,CC(=O)O,c1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20030055035A1,CC1(C)OCC(=O)CC1=O.N>>CC1(C)OCC(N)=CC1=O,,CCO,,O=S(=O)(O)O,,val
US20030203899A1,CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12>>CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12,,[Na+],[OH-],Cl,,val
US20100197681A1,COCCCN.O=C(Nc1nc2cccc(Cl)n2n1)c1ccccc1>>COCCCNc1cccc2nc(NC(=O)c3ccccc3)nn12,,C1CCOC1,,,,val
US20100292253A1,CCN(C(=O)OC(C)(C)C)c1cnc(Br)s1.O=C1CCC(=O)N1Cl>>CN(C(=O)OC(C)(C)C)c1sc(Br)nc1Cl,,CC#N,,,,val
US20110124618A1,CC(=O)OCCCBr.CCOC(=O)c1cc(-c2cccc(O)c2)n(-c2cccc(Cl)c2)n1>>CCOC(=O)c1cc(-c2cccc(OCCCOC(C)=O)c2)n(-c2cccc(Cl)c2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130072467A1,C1COCCN1.CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O>>CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCOCC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090099176A1,CSCCN1C(=O)C(NC(=O)c2cc3cc(Cl)ncc3[nH]2)Cc2ccccc21.O=S([O-])OO>>CS(=O)(=O)CCN1C(=O)C(NC(=O)c2cc3cc(Cl)ncc3[nH]2)Cc2ccccc21,,CCOC(C)=O,CO,O,,val
US20080227839A1,CC(C)Cn1c(N)nc2ccc(B(O)O)cc21.Fc1ccc(-c2nc3n(c2Br)CCC3)cc1>>CC(C)Cn1c(N)nc2ccc(-c3c(-c4ccc(F)cc4)nc4n3CCC4)cc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20070244173A1,C=CCn1c(C)nc2c3c(ccc21)[C@@H](OCCOC)[C@H](OC(=O)C(C)(C)C)[C@@H](c1ccccc1)O3>>C=CCn1c(C)nc2c3c(ccc21)[C@@H](OCCOC)[C@H](O)[C@@H](c1ccccc1)O3,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20040019042A1,NO.Nc1cccc(NS(=O)(=O)c2ccc3c(c2)C(=O)c2cc(S(=O)(=O)Nc4cccc(O)c4)ccc2-3)c1>>Nc1cccc(NS(=O)(=O)c2ccc3c(c2)C(=NO)c2cc(S(=O)(=O)Nc4cccc(O)c4)ccc2-3)c1,,c1ccncc1,,Cl,,val
US05489593,CCc1cccnc1N1CCNCC1.COc1ccc2cc(C(=O)O)[nH]c2c1C.O=C(n1ccnc1)n1ccnc1>>CCNc1cccnc1N1CCN(C(=O)c2cc3ccc(OC)c(C)c3[nH]2)CC1,,C1CCOC1,,,,val
US20100256113A1,Cc1c(COc2cccc(OCC3CCOCC3)c2)nc2ccc(Br)cc2c1OCc1ccccc1.OB(O)Oc1cccnc1>>Cc1c(COc2cccc(OCC3CCOCC3)c2)nc2ccc(-c3cccnc3)cc2c1OCc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20150018422A1,CCOC(=O)CC(c1cccc(CS(=O)c2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)c2)c1)C1CC1>>COc1ccc(F)c(-c2ccc(S(=O)Cc3cccc(C(CC(=O)O)C4CC4)c3)cc2CC(C)(C)C)c1,,CCO,,Cl,[Na+].[OH-],val
US20140296136A1,C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)NS(=O)(=O)C1(COC)CC1.O=C(O)C(F)(F)F>>C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)C1(COC)CC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20100286118A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN1C(=O)COc2ccc(Br)cc21>>CN1C(=O)COc2ccc(B3OC(C)(C)C(C)(C)O3)cc21,,CC#N,,CC(=O)[O-].[K+],,val
US20080009530A1,COC(=O)c1cc(OC(C)C)n[nH]1.ClCc1ccc(Cl)cc1Cl>>COC(=O)c1cc(OC(C)C)nn1Cc1ccc(Cl)cc1Cl,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05106871,COC(=O)CBr.COc1ccc(CCC(=O)c2ccc(OC)c(CCC(C)C)c2O)cc1>>COC(=O)COc1c(C(=O)CCc2ccc(OC)cc2)ccc(OC)c1CCC(C)C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080269193A1,Cc1nn(-c2ccc(C(N)=O)c(N[C@H]3CCCC[C@@H]3OCc3ccccc3)c2)c2c1C(=O)CC(C)(C)C2>>Cc1nn(-c2ccc(C(N)=O)c(N[C@H]3CCCC[C@@H]3O)c2)c2c1C(=O)CC(C)(C)C2,[Pd],CO,,,,val
US03932479,CCCCCC(=O)/C=C/Br>>CCCCCC(O)/C=C/Br,,CCO,,[BH4-].[Na+],,val
US04820873,O=Cc1cc2c3c(ccc4c3c1CCC4)CCC2>>O=Cc1cc2cccc3ccc4cccc1c4c32,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20150291595A1,Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(C(=O)O)c34)n(-c3ccccc3)c(=O)c12.Nc1cccc(O)c1>>Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(C(=O)Nc5cccc(O)c5)c34)n(-c3ccccc3)c(=O)c12,,CN(C)C=O,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20140148433A1,COc1ccc(CN2c3nc(-c4nn(Cc5ccccc5F)c5ncc(F)cc45)ncc3N(C)S2(=O)=O)c(OC)c1>>CN1c2cnc(-c3nn(Cc4ccccc4F)c4ncc(F)cc34)nc2NS1(=O)=O,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US06610692B1,[N-]=[N+]=N[C@@H]1COC[C@H]1OCC1CC1>>N[C@@H]1COC[C@H]1OCC1CC1,[Pd],CCOC(C)=O,,,,val
US05990101,Cc1sc2cncn2c1CN1C(=O)c2ccccc2C1=O>>Cc1sc2cncn2c1CN,,CCO,,NN,O,val
US04774253,CCOCc1ncc(-c2ccc(Cl)cc2)o1>>OCc1ncc(-c2ccc(Cl)cc2)o1,,O,,O=S(=O)(O)O,,val
US05108994,CCOP(=O)(CSCCO)OCC.O=C1c2ccccc2C(=O)N1c1ncnc2c1ncn2O>>CCOP(=O)(CSCCOn1cnc2c(N3C(=O)c4ccccc4C3=O)ncnc21)OCC,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150252032A1,CI.N#Cc1c[nH]c2ncccc12>>Cn1cc(C#N)c2cccnc21,,CN(C)C=O,,[H-].[Na+],,val
US20110165183A1,C[C@@H]1CCNC[C@@H]1NC(=O)OC(C)(C)C.ClCCl.N#CCC(=O)O>>C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US20070173498A1,O=C(Nc1ccc(CBr)cc1)c1ccccc1.Oc1ccc2c(c1)CCC(CCN1CCCCC1)C2>>O=C(Nc1ccc(COc2ccc3c(c2)CCC(CCN2CCCCC2)C3)cc1)c1ccccc1,,CCOC(C)=O,O,CN(C)C=O,[H-].[Na+],val
US20070015752A1,CC1(C)OC(=O)C(=C2C=CC(Br)=CN2)C(=O)O1.NCc1ccccc1>>O=C(Cc1ccc(Br)cn1)NCc1ccccc1,,Cc1ccccc1,,,,val
US20080200471A1,CC(C)(C)C(=O)Cl.Nc1cccc(O)c1>>CC(C)(C)C(=O)Nc1cccc(O)c1,,CCOC(C)=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US04269788,CC(=O)CC1(c2ccccc2)C=CCC=C1.CN>>CNC(C)CC1(c2ccccc2)C=CCC=C1,,CCOCC,CO,Cl,[BH3-]C#N.[Na+],val
US20060160794A1,CI.O=C(Nc1ccc(F)cc1Cl)c1nnn(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1-c1ccccc1>>CN(C(=O)c1nnn(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1-c1ccccc1)c1ccc(F)cc1Cl,,C1CCOC1,,,,val
US05439911,CCOC(=O)c1c(O)ncnc1CC.ClOCl>>CCOC(=O)c1c(Cl)ncnc1CC,,O,,[Na+].[OH-],,val
US20080293753A1,COC(=O)[C@]1(C)CC[C@H](c2ccc(OCc3ccccc3F)c(OC)c2)N1C(=O)OC(C)(C)C>>COc1cc([C@H]2CC[C@@](C)(C(=O)O)N2C(=O)OC(C)(C)C)ccc1OCc1ccccc1F,,CO,O,[Li]O,,val
US04945099,C=CCc1cc(C(C)=O)c(O)cc1OCCCCCC(=O)O.O=C(Cl)C(=O)Cl>>C=CCc1cc(C(C)=O)c(O)cc1OCCCCCC(=O)Cl,CN(C)C=O,ClCCl,,,,val
US20120088750A1,CCOC(=O)C1(CC)CCN(c2ncc(-c3cc(Br)c4sc(N5CN(C)CN(CC)C5=O)nc4c3)cn2)CC1.CN(C)C=O>>CCOC(=O)C1(CC)CCN(c2ncc(-c3cc(C=O)c4sc(N5CN(C)CN(CC)C5=O)nc4c3)cn2)CC1,,C1CCOC1,,[Li]CCCC,,val
US20130109682A1,CC1OC(c2ccncc2[N+](=O)[O-])C(O[Si](C)(C)C(C)(C)C)C(=O)C1(C)O>>CC1OC(c2ccncc2[N+](=O)[O-])C(O[Si](C)(C)C(C)(C)C)C(O)C1(C)O,,CO,,O,[BH4-].[Na+],val
US20130053382A1,C1=COCCC1.FC(F)(F)c1cc[nH]n1>>FC(F)(F)c1ccn(C2CCCCO2)n1,,CCOC(C)=O,Cc1ccccc1,O=C(O)C(F)(F)F,,val
US20050054657A1,BrBr.Oc1cccc2c1Sc1ccccc1S2>>Oc1ccc(Br)c2c1Sc1ccccc1S2,,CC(=O)O,,O,,val
US05962457,CC(=O)Cl.COC(=O)c1cscc1N>>COC(=O)c1cscc1NC(C)=O,,ClCCl,,CCN(CC)CC,Cl,val
US20120202690A1,CC=O.COC(=O)c1nc(-c2ccc(Cl)c(OC)c2F)nc(NCc2ccccc2)c1NCc1ccccc1>>COC(=O)c1nc(-c2ccc(Cl)c(OC)c2F)nc2c1N(Cc1ccccc1)C(C)N2Cc1ccccc1,,CCO,,,,val
US20120149676A1,C1COCCN1.CC(C)(O)CNc1cc(Cl)c(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1[N+](=O)[O-]>>CC(C)(O)CNc1cc(N2CCOCC2)c(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1[N+](=O)[O-],,CC#N,,CCN(C(C)C)C(C)C,,val
US20090054644A1,CC(Oc1ccc(C(F)(F)F)cn1)C1CN(C(=O)Cl)CC1c1ccc(Cl)c(Cl)c1.Cn1cncc1CN>>CC(Oc1ccc(C(F)(F)F)cn1)C1CN(C(=O)NCc2cncn2C)CC1c1ccc(Cl)c(Cl)c1,,ClCCl,,CCN(CC)CC,,val
US20080058332A1,CC(C)(C)OC(=O)N1CCC(C(=O)Nc2cccc(-c3nc(Cl)cc(-c4cccc(CO)c4)n3)c2)CC1.CC1CNCCO1>>CC1CN(c2cc(-c3cccc(CO)c3)nc(-c3cccc(NC(=O)C4CCNCC4)c3)n2)CCO1,,CC(=O)N(C)C,,O=C(O)C(F)(F)F,,val
US20160168096A1,CC1(C)OB(c2cc(F)c(O)c(F)c2)OC1(C)C.CCOC(=O)CCCCCBr>>CCOC(=O)CCCCCOc1c(F)cc(B2OC(C)(C)C(C)(C)O2)cc1F,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130331378A1,C[Si](C)(C)Cl.Clc1ccc2cc(N3CCCC3)nn2c1>>C[Si](C)(C)c1c(Cl)ccc2cc(N3CCCC3)nn12,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US07074819B2,CCOC(=O)C(CCCCOc1ccc(C2c3ccc(OCOC)cc3OCC2(C)c2ccc(OCOC)cc2)cc1)(CCCC(F)(F)C(F)(F)F)C(=O)OCC>>CC1(c2ccc(O)cc2)COc2cc(O)ccc2C1c1ccc(OCCCCC(CCCC(F)(F)C(F)(F)F)C(=O)O)cc1,,CCO,O,Cl,[K+].[OH-],val
US20090062280A1,COc1ccc2nc(C(C)(C)C)c(=O)n(CC(=O)N(CCC(C)(C)C)CC(C)(C)OP(=O)(O)OCc3ccccc3)c2c1>>COc1ccc2nc(C(C)(C)C)c(=O)n(CC(=O)N(CCC(C)(C)C)CC(C)(C)OP(=O)(O)O)c2c1,[Pd],CO,,[H][H],,val
US20080221101A1,C[C@@H](NCc1ccc(Cl)c(O[Si](C)(C)C(C)(C)C)c1)c1cccc(Cl)c1>>C[C@@H](NCc1ccc(Cl)c(O)c1)c1cccc(Cl)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20120208827A1,O=C(C1CC1)N1CC[C@@H](CNc2ccccc2[N+](=O)[O-])C1>>Nc1ccccc1NC[C@@H]1CCN(C(=O)C2CC2)C1,[Pd],CO,,,,val
US20140221349A1,COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CN3CCN(C(=O)OC(C)(C)C)CC3)ccc21>>COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CN3CCNCC3)ccc21,,C1COCCO1,ClCCl,Cl,O=C([O-])[O-].[K+].[K+],val
US04971982,CC(C)(Oc1ccc(C#N)cc1)C(O)Cc1ccnc[n+]1[O-]>>CC(C)(/C=C/c1ccnc[n+]1[O-])Oc1ccc(C#N)cc1,,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US20060100246A1,COc1ccc(COc2ccccc2-c2cc(C3=CCCN(C(=O)OC(C)(C)C)C3)c(CO)c(N)n2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1ccc(COc2ccccc2-c2cc(C3=CCCN(C(=O)OC(C)(C)C)C3)c3c(n2)NC(=O)OC3)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20070043065A1,CC(=O)OCC(=O)Cl.Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(OC[C@@H]3CCCN3)cc2c1=O>>Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(OC[C@@H]3CCCN3C(=O)CO)cc2c1=O,,CO,ClCCl,CCN(CC)CC,[Na+].[OH-],val
US20040058978A1,CC(=O)N1C(=O)C(=C(Cl)c2ccccc2)c2ccccc21.COc1ccc(N)cc1>>COc1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1,,ClCCl,,CCN(CC)CC,,val
US05270311,CCCN.COC(=O)COc1ccc(O)cc1>>CCCNC(=O)COc1ccc(O)cc1,,CO,,,,val
US04111923,CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1.Cl>>CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(C)C.Cl,[Pd],CO,,,,val
US20020049234A1,CCOC(=O)c1[nH]c2ccccc2c1N.COc1ccc(C(=O)Cl)cc1>>CCOC(=O)c1[nH]c2ccccc2c1NC(=O)c1ccc(OC)cc1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US05155264,CCN(CC)CC.O=C(O)CCl>>CC[N+](CC)(CC)CC(=O)O.[Cl-],,Cc1ccccc1,,,,val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.NC(=O)c1ccc(N)cc1>>COc1ccc2nc(Nc3ccc(C(N)=O)cc3)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US20090239865A1,BrC(Br)(Br)Br.OCc1cc(C(F)(F)F)cnc1Br>>FC(F)(F)c1cnc(Br)c(CBr)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120035168A1,Cc1cc(NC(=O)OC(C)(C)C)nc(C)c1CN.O=C(O)c1cn(Cc2ccc(CO)cc2)nn1>>Cc1cc(NC(=O)OC(C)(C)C)nc(C)c1CNC(=O)c1cn(Cc2ccc(CO)cc2)nn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140134110A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(NCCCOCC(N)(COCCCNC(C)=C1C(=O)CC(C)(C)CC1=O)COCCCNC(C)=C1C(=O)CC(C)(C)CC1=O)=C1C(=O)CC(C)(C)CC1=O>>CC(NCCCOCC(COCCCNC(C)=C1C(=O)CC(C)(C)CC1=O)(COCCCNC(C)=C1C(=O)CC(C)(C)CC1=O)N=C=O)=C1C(=O)CC(C)(C)CC1=O,CN(C)c1ccncc1,ClCCl,,,,val
US06124283,CN(C)C(=O)c1ccc(C(=O)O)cc1.CN1CCN(c2cccc3c2C[C@H](N)CC3)CC1>>CN1CCN(c2cccc3c2C[C@H](NC(=O)c2ccc(C(=O)N(C)C)cc2)CC3)CC1,,ClCCl,O=S(Cl)Cl,CCN(CC)CC,,val
US20020002200A1,COc1ccc(C=C(C(=O)O)c2ccc(O)cc2)cc1OC>>COc1ccc(CC(C(=O)O)c2ccc(O)cc2)cc1OC,[Pd],CCO,,,,val
US05753679,Cc1ccc(C(=O)OC2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)cc1>>Cc1ccc(C(=O)OC2CCN(Cc3cccc(N)c3)CC2)cc1,[Ni],CCO,,,,val
US20070270587A1,C=C[Sn](CCCC)(CCCC)CCCC.CC1(C)CN=C2N(C1)c1ccc(Br)cc1C21OCCCO1>>C=Cc1ccc2c(c1)C1(OCCCO1)C1=NCC(C)(C)CN12,,C1COCCO1,,,,val
US20100280011A1,CC(C)(C)OC(=O)NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(O)cc1.CC1(C(=O)O)CC1>>CC(C)(C)OC(=O)NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(OC(=O)C2(C)CC2)cc1,CN(C)c1ccncc1,c1ccncc1,,ClCCCl,,val
US20100331320A1,COCC(C)(O)C[C@]1(c2ccccc2)CCN([C@@H](C)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)C(=O)O1.Cn1ccc(I)cc1=O>>COCC(C)(O)C[C@]1(c2ccccc2)CCN([C@@H](C)c2ccc(-c3ccn(C)c(=O)c3)cc2)C(=O)O1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06100260,CC(=O)C(C)c1ccc(-c2ccccc2)c(F)c1.CCOC(=O)C(=O)OCC>>CCOC(=O)C(O)=CC(=O)C(C)c1ccc(-c2ccccc2)c(F)c1,,Cc1ccccc1,,O,[H-].[Na+],val
US20040087593A1,CI.O=S(=O)(c1ccc(F)cc1)c1c[nH]c2ccc(Br)cc12>>Cn1cc(S(=O)(=O)c2ccc(F)cc2)c2cc(Br)ccc21,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US04767882,CC(=O)Cl.Cc1ccc2c(c1)C(C)(C)[C@@H](C)CC2(C)C>>CC(=O)c1cc2c(cc1C)C(C)(C)[C@@H](C)CC2(C)C,,ClCCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20100210452A1,COC(=O)/C=C/C(=O)c1ccc(Br)cc1.O=CCCc1ccccc1Cl>>COC(=O)[C@H]1C=C(c2ccc(Br)cc2)OC(=O)[C@H]1Cc1ccccc1,,ClC(Cl)Cl,,,,val
US20080242663A1,CN(c1cccc(Cl)c1)c1cc[nH]c(=O)n1.O=P(Cl)(Cl)Cl>>CN(c1cccc(Cl)c1)c1ccnc(Cl)n1,CN(C)C=O,,,,,val
US20090306077A1,CN1CCN(CCCNCc2ccc(C(=O)Nc3ccccc3NC(=O)OC(C)(C)C)cc2)CC1.O=C=Nc1ccc2c(c1)OCCO2>>CN1CCN(CCCN(Cc2ccc(C(=O)Nc3ccccc3NC(=O)OC(C)(C)C)cc2)C(=O)Nc2ccc3c(c2)OCCO3)CC1,,ClCCl,,,,val
US20100240580A1,O=C(NCc1cccs1)c1ccc([N+](=O)[O-])c([N+](=O)[O-])c1>>Nc1ccc(C(=O)NCc2cccs2)cc1N,[Pd],C1CCOC1,CCO,,,val
US06211199B1,CC(C)(C)[Si](C)(C)OCCI.N#CCCc1ccccc1>>CC(C)(C)[Si](C)(C)OCCC(C#N)Cc1ccccc1,,CCCCCC,CCOC(C)=O,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US04371537,CC(C)S.CC(C)Sc1ccc(SC(C)C)c(C(=O)O)n1>>CC(C)Sc1ccc(SC(C)C)nc1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US03998834,CCC(=O)N(c1ccccc1)C1(COCc2ccccc2)CCN(CCc2ccccc2)CC1.Cl>>CCC(=O)N(c1ccccc1)C1(CO)CCN(CCc2ccccc2)CC1.Cl,[Pd],CO,,[H][H],,val
US20130323647A1,C=C(C)C(=O)OC1(C)C2CC3CC1CC(C(=O)O)(C3)C2.O=C(Cl)C(=O)Cl>>C=C(C)C(=O)OC1(C)C2CC3CC1CC(C(=O)Cl)(C3)C2,,Cc1ccccc1,,,,val
US04717418,CCC(=O)C1=C(O)CC(c2c(C)cc(C)cc2C)CC1=O.CCON>>CCON=C(CC)C1=C(O)CC(c2c(C)cc(C)cc2C)CC1=O,,CCO,,Cl,[Na+].[OH-],val
US20030207877A1,BrBr.CC(=O)c1ccc(C)o1>>Cc1ccc(C(=O)CBr)o1,,C1COCCO1,CCOCC,[Cl-].[NH4+],,val
US20090118222A1,CC(C)[SiH](Cl)C(C)C.CCCCC>>CCCC[SiH](C(C)C)C(C)C,,C1CCOC1,,[Cl-].[NH4+],,val
US20100240698A1,COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCCCC(=O)N4C3)cc(-c3csc(NC(C)C)n3)nc2c1.NS(=O)(=O)C1CC1>>COc1ccc2c(OC3CC4C(=O)NC5(C(=O)NS(=O)(=O)C6CC6)CC5C=CCCCCCCC(=O)N4C3)cc(-c3csc(NC(C)C)n3)nc2c1,,C1CCOC1,,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US05250669,CC(=O)C(=[N+]=[N-])C(=O)CCc1ccc(S(=O)(=O)Cl)cc1.CCO>>CCOS(=O)(=O)c1ccc(CCC(=O)C(=[N+]=[N-])C(C)=O)cc1,,CCN(CC)CC,,O,,val
US04259336,O=C(Cl)c1sc2ccccc2c1Cl.O=S([O-])O.[Na+].[OH-]>>O=C(O)c1sc2ccccc2c1S(=O)(=O)[O-].[Na+],Cl[Cu],O,,Cl,,val
US04968848,C[Si](C)(C)C(F)(F)F.O=Cc1ccccc1>>OC(c1ccccc1)C(F)(F)F,,CCCCCC,,O,,val
US20040037022A1,C/C(=N\[Si](C)(C)C)O[Si](C)(C)C.CC(C)(C)OC(=O)N(C[C@H](O)c1cccc(Cl)c1)[C@H](CO)Cc1ccc(N)cc1.CN1CCCC1=O.NC(N)=O.O=C(O)C(F)(F)F.[N-]=C=O>>CC(C)(C)OC(=O)N(C[C@H](O)COc1ccccc1)[C@H](CO)Cc1ccc(NC(=O)c2ccc[nH]2)cc1,,O,,CCN(C(C)C)C(C)C,,val
US04107326,Cl.N=C(NCc1ccccc1)NN=Cc1c(Cl)cccc1Cl>>Cl.N=C(NCc1ccccc1)NN=Cc1c(Cl)cccc1Cl,,CC(C)O,,CCO,,val
US20050143422A1,COC(=O)[C@@H](NS(=O)(=O)c1ccc(-c2ccc(NC(=O)c3oc4cccc(OC)c4c3C)cc2)cc1)C(C)C>>COc1cccc2oc(C(=O)Nc3ccc(-c4ccc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)cc4)cc3)c(C)c12,,C1CCOC1,,[Li+].[OH-],,val
US06248755B1,CC1[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](c2cccc(F)c2)CN1C(=O)OC(C)(C)C.COc1ccc(COC(=O)[C@@H](C(C)C)N2C[C@H](c3ccccc3)[C@@H](C=O)C2)cc1>>CC1[C@H](CO)[C@@H](c2cccc(F)c2)CN1[C@H](CC1CC1)C(=O)OCc1ccccc1,,Cl,ClCCl,CCN(C(C)C)C(C)C,CO,val
US20090018123A1,COC(=O)Cl.NC[C@H]1CN(c2cc(F)c(N3CCC(n4ncnn4)CC3)c(F)c2)C(=O)O1>>COC(=O)NC[C@H]1CN(c2cc(F)c(N3CCC(n4ncnn4)CC3)c(F)c2)C(=O)O1,,ClCCl,,CCN(CC)CC,,val
US20130029968A1,CCc1cc(OC)c(F)cc1-c1ccc2cnn(C3CCCCO3)c2c1>>CCc1cc(OC)c(F)cc1-c1ccc2cn[nH]c2c1,,CO,,Cl,,val
US06057369,CCOC(=O)/C(C)=C/CCCCc1ccccc1>>C/C(=C\CCCCc1ccccc1)C(=O)O,,CO,O,[Na+].[OH-],,val
US20070066820A1,O=C1c2ccccc2C(=O)N1CCCN1CCC[C@H]1COc1ccc(Oc2ccc(Cl)cc2)cc1>>NCCCN1CCC[C@H]1COc1ccc(Oc2ccc(Cl)cc2)cc1,,CO,,NN,O,val
US20100120741A1,CN.O=[N+]([O-])c1cnc2ccc(Cl)cc2c1Cl>>CNc1c([N+](=O)[O-])cnc2ccc(Cl)cc12,,C1CCOC1,,,,val
US04200578,C#CCN.CSC(=C[N+](=O)[O-])NCCSCc1csc(NC(=N)N)n1>>C#CCNC(=C[N+](=O)[O-])NCCSCc1csc(NC(=N)N)n1,,CC#N,,,,val
US20020068737A1,O=C1COCC(c2ccc(F)c(F)c2)N1>>Fc1ccc(C2COCCN2)cc1F,,C1CCOC1,CCOCC,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130168656A1,OC(c1cccc(Br)c1)(c1ccccn1)c1ccccc1-c1ccccc1>>Brc1cccc(C2(c3ccccn3)c3ccccc3-c3ccccc32)c1,,CC(=O)O,,Cl,,val
US20110160243A1,CCOC(=O)CC1CCN(c2ccc(O)cc2N)C1=O>>CCOC(=O)CC1CCn2c1nc1cc(O)ccc12,,CC(=O)O,,,,val
US20150080549A1,CSSC(CN=[N+]=[N-])C[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C.C[Si](C)(C)Cl>>CSSC(CN=[N+]=[N-])C[C@H](N)C(=O)O.Cl,,OCC(F)(F)F,,,,val
US20100222321A1,CCCn1cnc(C(=O)OC)c1>>CCCn1cnc(C(=O)O)c1,,CO,,Cl,[Li+].[OH-],val
US20160081340A1,CCC(=O)c1ccc(O)c(C)c1.Cn1nnn(-c2ccccc2CBr)c1=O>>CCC(=O)c1ccc(OCc2ccccc2-n2nnn(C)c2=O)c(C)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20020143020A1,CC[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)OCc1c(F)cc(OCC2CC2)cc1F>>CC[C@@H]1CNCCN1C(=O)OCc1c(F)cc(OCC2CC2)cc1F,,C1COCCO1,CO,Cl,[Na+].[OH-],val
US20080051397A1,COC(=O)c1ccc(CN)cc1.O=Cc1ccccc1>>COC(=O)c1ccc(CNCc2ccccc2)cc1,,CCO,,[BH4-].[Na+],,val
US20130184284A1,CCOC(=O)C1(C)CCCN(C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N1CCCC(C)(C(=O)O)C1,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US06110924,BrBr.O=C1NC(=O)C(c2cccc3ccccc23)C(=O)N1>>O=C1NC(=O)C(Br)(c2cccc3ccccc23)C(=O)N1,,CCO,,Br,,val
US20140011800A1,CC(C)(C)OC(=O)N1CC[C@@H](Nc2c(C(N)=O)cnn3cc(C(=O)O)cc23)C(C)(C)C1.NN>>CC(C)(C)OC(=O)N1CC[C@@H](Nc2c(C(N)=O)cnn3cc(C(=O)NN)cc23)C(C)(C)C1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US05889010,Nc1ccc(F)cc1[N+](=O)[O-].O=C(Cl)CCBr>>O=C(CCBr)Nc1ccc(F)cc1[N+](=O)[O-],,O,,CCN(C(C)C)C(C)C,ClCCl,val
US20090156612A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2ncn([C@H]3CCCCC3(O)CCO)c2-c2ccccc2)[C@H](Cc2ccccc2)C1.CI>>COCCC1(O)CCCC[C@@H]1n1cnc(C(=O)N2CCN(C(=O)OC(C)(C)C)C[C@H]2Cc2ccccc2)c1-c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20130012499A1,CCC(=O)c1cccc(C(F)(F)F)c1.O=C1Nc2ccc(F)cc2C1=O>>Cc1c(-c2cccc(C(F)(F)F)c2)nc2ccc(F)cc2c1C(=O)O,,CCO,O,[K+].[OH-],,val
US20060074111A1,CCCCNCc1ccc(OCC(=O)OCC)c(C)c1.CS(=O)(=O)c1nccc(-c2ccc(Cl)cc2)n1>>CCCCN(Cc1ccc(OCC(=O)OCC)c(C)c1)c1nccc(-c2ccc(Cl)cc2)n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04908394,C1COCCN1.Nc1ccc(C(=O)OCCCCl)c(N)c1>>Nc1ccc(C(=O)OCCCN2CCOCC2)c(N)c1,,O,,Cc1ccccc1,,val
US06335344B1,C#Cc1cccc(N)c1.Clc1ncnc2cc3c(cc12)OCO3>>C#Cc1cccc(Nc2ncnc3cc4c(cc23)OCO4)c1,,CC(C)O,,,,val
US20130274244A1,COCCOc1ccn2c(C(=O)Nc3cccc4c3cnn4CC3CCCN(C(=O)OC(C)(C)C)C3)cnc2c1.Cl>>COCCOc1ccn2c(C(=O)Nc3cccc4c3cnn4CC3CCCNC3)cnc2c1.Cl,,C1COCCO1,ClCCl,,,val
US05753664,CCn1c(SC)nc2c(c(C)cn2Cc2ccc(C(=O)c3ccc(F)cc3)cc2)c1=O>>CCn1cnc2c(c(C)cn2Cc2ccc(C(=O)c3ccc(F)cc3)cc2)c1=O,[Ni],CCO,COCCOC,CC(=O)O,,val
US04041169,CC(=O)COC(C)=O.CCOC(C)=O.OCCc1c[nH]c2ccccc12>>CC(=O)O.CC(=O)OCC1(C)OCCc2c1[nH]c1ccccc21,,CCOC(C)=O,c1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20150353559A1,CS(=O)(=O)c1cc(Cl)cc(C=O)c1.O=C(O)CC(=O)O>>CS(=O)(=O)c1cc(Cl)cc(/C=C/C(=O)O)c1,,c1ccncc1,,C1CCNCC1,Cl,val
US04514414,COC(=O)CC1CCN(CCC#Cc2ccccc2)C1>>O=C(O)CC1CCN(CCC#Cc2ccccc2)C1,,CO,,[Na+].[OH-],,val
US20130109649A1,COc1ncc(-c2ccc(C(=O)OC(C)(C)C)cc2C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OC(=O)N21>>COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OC(=O)N21,,ClCCl,O=C(O)C(F)(F)F,,,val
US05594140,CCN(C(C)C)C(C)C.CNC.O=C(Cl)c1cc(O)nc2ccccc12>>NC(=O)c1c(N2CCCC2)c(O)nc2ccccc12,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US05086055,CN1CC(CCCl)OC1=O.Fc1ccc(N2CCNCC2)cc1>>CN1CC(CCN2CCN(c3ccc(F)cc3)CC2)OC1=O,,CCCCO,,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20040204386A1,CCOc1ccc(Cl)cc1-c1cc(Cl)nc(N)n1.Nc1ccc(-c2cnco2)cc1>>CCOc1ccc(Cl)cc1-c1cc(Nc2ccc(-c3cnco3)cc2)nc(N)n1,,C1COCCO1,,CCO,Cl,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCC)cc1CC2CC>>CCOc1cc2c(cc1OC)-c1cc(=O)c(C(=O)O)cn1C(CC)C2,,CO,O,[Li]O,,val
US20110003815A1,CN(C)/C=C\C(=O)c1ccc(C2(c3ccc(OCc4ccccn4)cc3)CC3CCC2C3)cc1.NO>>c1ccc(COc2ccc([C@@]3(c4ccc(-c5ccno5)cc4)CC4CCC3C4)cc2)nc1,,CCO,,Cl,,val
US20040186127A1,CN(C(=O)OC(C)(C)C)C1CCC2(CC1)OCC(C)(C)CO2>>CN(C(=O)OC(C)(C)C)C1CCC(=O)CC1,,CC(C)=O,O,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20150152114A1,CC(=O)Nc1c(O)nc(S)nc1O.CCCBr>>CCCSc1nc(O)c(NC(C)=O)c(O)n1,,CO,,Cl,[Na+].[OH-],val
US04323680,COc1ccccc1OCCN.Cc1ccc2ncnc(Cl)c2c1>>COc1ccccc1OCCc1nc(N)nc2ccc(C)cc12,,c1ccccc1,,CCN(CC)CC,,val
US20050256154A1,CC(N)CO.CCOC(=O)c1cnc(N)c2c(COc3ccc(Br)cc3)csc12>>CC(CO)NC(=O)c1cnc(N)c2c(COc3ccc(Br)cc3)csc12,,CCOC(C)=O,,,,val
US06300363B1,COC(C)C(=O)O.Nc1c(C(=O)c2ccccc2)[nH]c2cc(Cl)ccc12>>COC(C)C(=O)Nc1c(C(=O)c2ccccc2)[nH]c2cc(Cl)ccc12,,CCCCCC,CCOC(C)=O,,,val
US20100190766A1,COC(=O)[C@H](CNC(=O)OC(C)(C)C)NC(=O)c1ccc(C#Cc2ccccc2)cc1>>COC(=O)[C@H](CN)NC(=O)c1ccc(C#Cc2ccccc2)cc1,,C1COCCO1,CO,Cl,,val
US04242519,CC(C)Br.COC(=O)C(SC)c1cccc(Oc2ccccc2)c1>>COC(=O)C(SC)(c1cccc(Oc2ccccc2)c1)C(C)C,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US05792763,BrCc1csc2ccc(Br)cc12.[C-]#N>>N#CCc1csc2ccc(Br)cc12,,CCO,,O,,val
US20140274688A1,Brc1nc[nH]n1.FC(F)(F)Oc1ccc(I)cc1>>FC(F)(F)Oc1ccc(-n2cnc(Br)n2)cc1,[Cu]I,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04751299,CO.O=C(N[C@@H]1C(=O)N[C@@H]1C=Cc1ccccc1)OCc1ccccc1>>O=C(N[C@@H]1C(=O)N[C@@H]1CO)OCc1ccccc1,,ClCCl,,,,val
US20090137499A1,CCc1ccc(Cc2ccc(CO)cc2O[C@@H]2O[C@H](COC)[C@@H](O)[C@H](O)[C@H]2O)cc1.CCc1ccc(Cc2ccc(COC(C)=O)cc2O[C@@H]2O[C@H](COC(=O)c3ccccc3)[C@@H](OC)[C@H](OC(=O)c3ccccc3)[C@H]2OC(=O)c2ccccc2)cc1>>CCc1ccc(Cc2ccc(CO)cc2O[C@@H]2O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]2O)cc1,,ClCCl,,CO,O=C([O-])[O-].[K+].[K+],val
US20160060260A1,Cn1cnc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCC4(C)CO4)c2)n(C)c(=O)n3C)c1.O=S(=O)(O)O>>Cn1cnc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCC(C)(O)CO)c2)n(C)c(=O)n3C)c1,,C1CCOC1,O,,,val
US20010049371A1,CCOc1cc(C(N)CC(=O)O)ccc1OC.Cc1ccc2c(c1)C(=O)OC2=O>>CCOc1cc(C(CC(=O)O)N2C(=O)c3ccc(C)cc3C2=O)ccc1OC,,CC(=O)O,O,CCCCCC,CCOC(C)=O,val
US20090023763A1,Nc1cc(-c2ccncc2)c(-c2ccco2)nc1N.O=C(Cl)C1CC1>>Nc1nc(-c2ccco2)c(-c2ccncc2)cc1NC(=O)C1CC1,,C1CCOC1,,CCN(CC)CC,,val
US20150018547A1,COC(=O)Cc1csc2cc(OCc3cc(C)nn3C)cc(Cl)c12>>Cc1cc(COc2cc(Cl)c3c(CC(=O)O)csc3c2)n(C)n1,,CCO,,[Na+].[OH-],,val
US20070060736A1,C1CCOC1.CCCC[Mg]Cl.O=C1C=Cc2c(ccc3ccccc23)C1=O>>CCCCC1(O)c2ccccc2-c2ccccc2C1(O)CCCC,,C1CCOC1,,[Cl-].[NH4+],,val
US20150119362A1,CCc1cc(Nc2ncc(CC(=O)OC)o2)nc(-c2cccc(Cl)c2)n1.N>>CCc1cc(N=c2[nH]cc(CC(N)=O)o2)nc(-c2cccc(Cl)c2)n1,,CO,,[Cl-].[NH4+],,val
US04746352,CCOC(=O)c1cc(NC(N)=O)ccc1Cl.CCOC=CC(=O)OCC>>CCOC(=O)C=CNC(=O)Nc1ccc(Cl)c(C(=O)OCC)c1,,COCCOC,,Cl,,val
US20160143895A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cccnc3)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(C3CCCNC3)cc12,O=[Pt]=O,CO,Cl,,,val
US05451582,CC(C)C1=NC(NC(=O)OCc2ccccc2)C(=O)Nc2ccccc21.CC(C)CI>>CC(C)CN1C(=O)C(NC(=O)OCc2ccccc2)N=C(C(C)C)c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20060100262A1,COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(=O)N(CCN(C)C)Cc1ccoc1-3>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCN(CCN(C)C)Cc1ccoc1-3,,C1CCOC1,,CSC,,val
US20110003787A1,COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc(-c2ccc(C3=NC[C@H](CO[Si](C(C)C)(C(C)C)C(C)C)O3)[nH]2)c1>>COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc(-c2ccc(C3=NC[C@H](CO)O3)[nH]2)c1,,C1CCOC1,,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20060030610A1,CS(N)(=O)=O.Cc1noc2c(F)c(Nc3ccc(Br)cc3Cl)c(C(=O)O)cc12>>Cc1noc2c(F)c(Nc3ccc(Br)cc3Cl)c(C(=O)NS(C)(=O)=O)cc12,,C1CCOC1,CCOC(C)=O,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US06867200B1,O=C(O)CCc1ccc(O)c(C(=O)CCc2ccccc2)c1.O=C1CCC(=O)N1Br>>O=C(O)CCc1cc(Br)c(O)c(C(=O)CCc2ccccc2)c1,,CCOCC,CN(C)C=O,,,val
US20080167307A1,CCOC(=O)c1ccc(Cl)nc1.OB(O)Oc1ccccc1>>CCOC(=O)c1ccc(-c2ccccc2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20130018033A1,CCOC(=O)c1cccc2c(O)ncnc12.COc1ccc(CN)c(OC)c1>>CCOC(=O)c1cccc2c(NCc3ccc(OC)cc3OC)ncnc12,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US20130225524A1,COC(=O)c1cc(N)cc([N+](=O)[O-])c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1cc(NS(=O)(=O)C(F)(F)F)cc([N+](=O)[O-])c1,,ClCCl,,CCN(CC)CC,[Na+].[OH-],val
US20090270475A1,CC(C)(C)OC(=O)Nc1ncc(-c2ccc(C#Cc3ccccc3)cc2)n1C(=O)OC(C)(C)C>>Nc1ncc(-c2ccc(C#Cc3ccccc3)cc2)[nH]1,,ClCCl,,Cc1ccccc1,O=C(O)C(F)(F)F,val
US20090186879A1,COC(=O)c1ccc(Cl)c(N)c1NCCCO.FC(F)(F)c1cc(Cl)ccc1N=C=S>>COC(=O)c1ccc(Cl)c(NC(=S)Nc2ccc(Cl)cc2C(F)(F)F)c1NCCCO,,C1CCOC1,,,,val
US20160221971A1,COC(=O)c1ccc(C(=O)OC)n(O)c1=O.ClCc1ccccc1>>COC(=O)c1ccc(C(=O)OC)n(OCc2ccccc2)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04853410,CC1(C)CC(=O)c2ccccc2O1.O=[N+]([O-])O>>CC1(C)CC(=O)c2cc([N+](=O)[O-])ccc2O1,,O=S(=O)(O)O,,O,,val
US20110172221A1,CCC(=O)c1cc(Br)ccc1F.NN>>CCc1n[nH]c2ccc(Br)cc12,,CN1CCCC1=O,,O,O,val
US04187216,CCCCCC(=O)OC(=O)CCCCC.C[C@H](N)C(=O)N1CCC[C@H]1C(=O)Nc1ccccc1>>CCCCCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)Nc1ccccc1,,c1ccncc1,,Br,,val
US20090306066A1,CNCc1nccs1.CSc1nc(Cl)c(F)c(Cl)n1>>CSc1nc(Cl)c(F)c(N(C)Cc2nccs2)n1,,C1CCOC1,O,CCN(CC)CC,,val
US20090275583A1,BrCCCBr.C=C(C)[C@@H]1CC[C@]2(C(=O)NCCc3cccc(C(=O)NCc4ccc(O)cc4)c3)CC[C@]3(C)C(CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12>>C=C(C)[C@@H]1CC[C@]2(C(=O)NCCc3cccc(C(=O)NCc4ccc(OCCCBr)cc4)c3)CC[C@]3(C)C(CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100249163A1,CC(C)(C)OC(=O)N1CC[C@](O)(c2ccc(F)c(F)c2)[C@@H](C(=O)N(Cc2cccc(Cl)c2Cl)C2CC2)C1.CI>>CO[C@]1(c2ccc(F)c(F)c2)CCN(C(=O)OC(C)(C)C)C[C@@H]1C(=O)N(Cc1cccc(Cl)c1Cl)C1CC1,,CN(C)C=O,,[H-].[Na+],,val
US20020025948A1,CC1(c2cccc([N+](=O)[O-])c2)C2C(=O)N(Cc3ccccc3)C(=O)C21>>CC1(c2cccc(N)c2)C2C(=O)N(Cc3ccccc3)C(=O)C21,[Pt],CCOC(C)=O,,,,val
US20160106754A1,CC1(C)CC(=O)C(Br)c2n[nH]cc21.Nc1ccccc1S>>CC1(C)C(=O)C2=C(Sc3ccccc3N2)c2n[nH]cc21,CCN(CC)CC,,,CCO,,val
US05231183,CNCc1cccc2c(Cl)csc12.ClC=CCCl>>CN(C/C=C/Cl)Cc1cccc2c(Cl)csc12,,CS(C)=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20100179210A1,CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccc(N)cc4Cl)oc23)[C@@H]1CO.Cl>>CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccc(N)cc4Cl)oc23)[C@@H]1CO.Cl,,CO,,,,val
US20150105391A1,Cc1cc([N+](=O)[O-])cc(C)c1-c1csc(N)n1.O=C(Cl)c1ccncc1>>Cc1cc([N+](=O)[O-])cc(C)c1-c1csc(NC(=O)c2ccncc2)n1,CN(C)c1ccncc1,ClCCl,,Cl,,val
US20060189606A1,CCn1c(-c2ccc(N)cc2)c(C#N)c2ccc(OC)cc21.O=C=NCCCl>>CCn1c(-c2ccc(NC(=O)NCCCl)cc2)c(C#N)c2ccc(OC)cc21,,C1CCOC1,,,,val
US20060258689A1,CC1(C)C(=O)Nc2cc([N+](=O)[O-])ccc21>>CC1(C)CNc2cc([N+](=O)[O-])ccc21,,C1CCOC1,,,,val
US05912244,CC1(C)Oc2ccc(S(=O)(=O)c3cccc(O[Si](C)(C)C(C)(C)C)c3)cc2[C@@H]2O[C@@]21C.N>>CC1(C)Oc2ccc(S(=O)(=O)c3cccc(O)c3)cc2[C@@H](N)[C@]1(C)O,,CCO,,,,val
US20020147188A1,CC1(C)CC2OC2CN(S(=O)(=O)c2ccccn2)C1.[N-]=[N+]=[N-]>>CC1(C)CC(N=[N+]=[N-])C(O)CN(S(=O)(=O)c2ccccn2)C1,,CO,O,[Cl-].[NH4+],,val
US20120190683A1,CNc1ccc(C(F)(F)F)cc1.FC(F)(F)COc1cc(OCC(F)(F)F)nc(N=C=S)n1>>CN(C(=S)Nc1nc(OCC(F)(F)F)cc(OCC(F)(F)F)n1)c1ccc(C(F)(F)F)cc1,,ClCCl,,,,val
US20050267149A1,CCCCCCCNCCc1ccc(Cl)cc1.COC(=O)c1ccccc1OCc1ccc(CC(=O)O)cc1>>CCCCCCCN(CCc1ccc(Cl)cc1)C(=O)Cc1ccc(COc2ccccc2C(=O)OC)cc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20070015744A1,CC(C)(C)OC(=O)N1CCN(c2cccc(NCc3ccccc3)c2[N+](=O)[O-])CC1>>CC(C)(C)OC(=O)N1CCN(c2cccc(NCc3ccccc3)c2N)CC1,,CCO,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20130237519A1,Cc1ccc(C(=O)NCc2ccccc2N2CCN(C)CC2)cc1N.O=C(O)c1cnn2cc(Br)ccc12>>Cc1ccc(C(=O)NCc2ccccc2N2CCN(C)CC2)cc1NC(=O)c1cnn2cc(Br)ccc12,,CCOC(C)=O,CO,O=S(Cl)Cl,c1ccncc1,val
US05472978,CN=C=O.Cc1cc(C)cc(COC(=O)C(N)Cc2c[nH]c3ccccc23)c1>>CNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20110124634A1,CC(C)(C)OC(=O)CCNc1cc(Cl)nc(N)n1>>Nc1nc(Cl)cc(NCCC(=O)O)n1,,O=C(O)C(F)(F)F,,,,val
US03933886,CCOC(=O)CC(=O)c1ccccc1.Nc1ccc(N)c([N+](=O)[O-])c1>>Nc1ccc(NC(=O)CC(=O)c2ccccc2)cc1[N+](=O)[O-],,Cc1ccccc1C,,CCO,,val
US05200513,COc1cccc(C(=O)O)c1>>O=C1CC=CC(C(=O)O)C1,,N,,[Li],,val
US20100029753A1,COC(=O)c1sccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1-c1cncnc1>>CC(C)(C)c1ccc(S(=O)(=O)Nc2ccsc2C(=O)O)c(-c2cncnc2)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20120238587A1,CC1(C)OB(c2cnc(Cl)c(NS(=O)(=O)c3ccc(F)cc3F)c2)OC1(C)C.Cc1noc(C)c1Nc1ncnc2ccc(Cl)nc12>>Cc1noc(C)c1Nc1ncnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4F)c3)nc12,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20100087424A1,CS(=O)(=O)Cl.O=c1ccc2ccc(F)c3c2n1[C@H](CO)CO3>>CS(=O)(=O)OC[C@@H]1COc2c(F)ccc3ccc(=O)n1c23,,ClCCl,,CCN(CC)CC,,val
US20040087619A1,CO.COc1ccc2ncc(F)c(C(=O)CC[C@@H]3CCN(C(=O)OC(C)(C)C)C[C@@H]3C(=O)O)c2c1>>COC(=O)[C@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1CCC(=O)c1c(F)cnc2ccc(OC)cc12,,CO,ClCCl,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US20040102460A1,BrC1CCCC1.CCCCc1nc(C(F)(F)F)nc2nc[nH]c12>>CCCCc1nc(C(F)(F)F)nc2c1ncn2C1CCCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120208844A1,COC(=O)CCc1ccccc1C1=CCN(C(=O)OC(C)(C)C)CC1>>COC(=O)CCc1ccccc1C1CCN(C(=O)OC(C)(C)C)CC1,O=[Pt]=O,CC(=O)O,CCO,,,val
US20060106027A1,CN1CCC(OCc2cccc([N+](=O)[O-])c2)CC1>>CC(OC1CCNCC1)c1cccc(N)c1,[Fe],,,CC(=O)O,,val
US06239151B1,CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)Cc1nnn[nH]1)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1>>CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)Cc1nnn[nH]1)[C@H](C/C=C/c1ccccc1)C(=O)NO,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140113877A1,Cc1ccc(Cn2c(=O)n(C3CCN(C(=O)OC(C)(C)C)CC3)c(=O)c3sc(-c4ccccc4)cc32)cc1F.Cl>>Cc1ccc(Cn2c(=O)n(C3CCNCC3)c(=O)c3sc(-c4ccccc4)cc32)cc1F.Cl,,C1COCCO1,,,,val
US05536701,CCCCC([Sn])=C(CCCC)CCCC.CN(C)C=O.Cn1nc(C(F)(F)F)cc1Oc1cc(Br)cnn1>>C=Cc1cnnc(Oc2cc(C(F)(F)F)nn2C)c1,,CN(C)C=O,,CCOC(C)=O,,val
US20130059835A1,CCOc1c(C(C)=O)cc(Cl)c(C#N)c1N1CC(OC)C1>>CCOc1c(C(C)O)cc(Cl)c(C#N)c1N1CC(OC)C1,,CO,,[BH4-].[Na+],,val
US20040132727A1,CC(O)c1ccccc1Br.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)OC(C)c4ccccc4Br)cc3)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US05237059,COc1c2ccccc2c(OC)c2cc(S(=O)(=O)Cl)ccc12.O=C1c2ccccc2C(=O)N1O>>COc1c2ccccc2c(OC)c2cc(S(=O)(=O)ON3C(=O)c4ccccc4C3=O)ccc12,,CCN(CC)CC,,C1CCOC1,,val
US20160168158A1,CCN.FC1(F)CCN(c2nc(Cl)nc3c2nnn3Cc2ccccc2Cl)C1>>CCNc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04066776,CN.Cn1cc(C(=O)Cl)c([N+](=O)[O-])n1>>CNC(=O)c1cn(C)nc1[N+](=O)[O-],,O,,,,val
US20130217664A1,CCB(CC)CC.Nc1cc(F)ccc1I>>CCc1ccc(F)cc1N,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06699650B1,O=C(Nc1cc(Cl)c([N+](=O)[O-])cc1O)c1ccc(Cl)c(Cl)c1>>Nc1cc(O)c(NC(=O)c2ccc(Cl)c(Cl)c2)cc1Cl,[Ni],CCOC(C)=O,CN(C)C=O,,,val
US20060020038A1,CC(C)(Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)Sc1cc(C(C)(C)C)c(OCC[C@H](O)C(=O)O)c(C(C)(C)C)c1>>CC(C)(Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)Sc1cc(C(C)(C)C)c(OCC[C@H](O)CO)c(C(C)(C)C)c1,,C1CCOC1,,B,,val
US20070037802A1,CCNCC.Cc1ccc(S(=O)(=O)OCCOc2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)cc1>>CCN(CC)CCOc1ccc2[nH]nc(S(=O)(=O)c3ccccc3)c2c1,,C1CCOC1,,,,val
US05821240,CC(=O)OC(C)=O.Fc1ccc(Nc2ncnc3cnc(NCCN4CCNCC4)nc23)cc1Cl>>CC(=O)N1CCN(CCNc2ncc3ncnc(Nc4ccc(F)c(Cl)c4)c3n2)CC1,,CO,ClCCl,,,val
US20070244132A1,CC(=O)OCCCCCBr.Clc1ncnc2cc[nH]c12>>CC(=O)OCCCCCn1ccc2ncnc(Cl)c21,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20120122780A1,CCOC=C(C(=O)OCC)C(=O)OCC.NNc1cccc2ccccc12>>CCOC(=O)c1cnn(-c2cccc3ccccc23)c1O,,O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20150025070A1,CCOC(=O)N(CCBr)CCBr.COc1ccc2c(c1)CCC2=O>>CCOC(=O)N1CCC2(CC1)Cc1cc(OC)ccc1C2=O,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US05731315,CI.N#Cc1cccc(CN2CC[C@H](NS(=O)(=O)c3cc4nc(Cl)ccc4s3)C2=O)c1>>CN([C@H]1CCN(Cc2cccc(C#N)c2)C1=O)S(=O)(=O)c1cc2nc(Cl)ccc2s1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20110257187A1,NN.O=C1OC(=Cc2ccccc2)c2cc(Br)ccc21>>O=c1[nH]nc(Cc2ccccc2)c2cc(Br)ccc12,,CCO,,,,val
US20160002175A1,Cc1ccc(NCCN)cc1F.Cc1cccc(-c2cc(Cl)nc(N)n2)c1C>>Cc1ccc(NCCNc2cc(-c3cccc(C)c3C)nc(N)n2)cc1F,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20110021522A1,Nc1cccc(-c2ccn[nH]2)c1.O=C(O)c1cc2cccc(O)c2oc1=O>>O=C(Nc1cccc(-c2ccn[nH]2)c1)c1cc2cccc(O)c2oc1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04703054,CC1(C)NCC(=O)N1CC(N)=O.C[C@H](NC(=O)OCc1ccccc1)C(=O)O>>CC(NC(=O)OCc1ccccc1)C(=O)N1CC(=O)N(CC(N)=O)C1(C)C,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20090105214A1,COC[C@H](C)Oc1cc(Oc2ccc3c(c2)OCCN(C)C3=O)cc(C(=O)O)c1.Cc1cnc(N)cn1>>COC[C@H](C)Oc1cc(Oc2ccc3c(c2)OCCN(C)C3=O)cc(C(=O)Nc2cnc(C)cn2)c1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20050209225A1,CCOC(=O)C=C(c1ccccc1)n1ccc2cc(CCCc3ccc4cccnc4n3)ccc21>>CCOC(=O)CC(c1ccccc1)n1ccc2cc(CCCc3ccc4c(n3)NCCC4)ccc21,[Pd],CO,,,,val
US04165334,CCCCCCCCCCCCCCCCCCS.Cc1ccc(S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCO)cc1>>CCCCCCCCCCCCCCCCCCSCCOCCOCCOCCOCCOCCOCCOCCOCCO,,COCCOC,,[H-].[Na+],,val
US20110230458A1,CC(C)(C)OC(=O)N1CCC(O)C(CN=[N+]=[N-])C1>>CC(C)(C)OC(=O)N1CCC(O)C(CN)C1,[Pd],CCOC(C)=O,,[H][H],,val
US20160016948A1,COC(C)(C)C#Cc1nccc(Nc2cc3c(cn2)nc(C)n3C(C)C)n1>>COC(C)(C)CCc1nccc(Nc2cc3c(cn2)nc(C)n3C(C)C)n1,[Pd],CCO,,[H][H],,val
US05246948,O=C1c2ccccc2C(=O)N1CCCBr.Oc1ccncc1>>O=C1c2ccccc2C(=O)N1CCCOc1ccncc1,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US05977075,COC(=O)[C@@H](Cc1ccc(OS(=O)(=O)C(F)(F)F)cc1)NC(=O)OC(C)(C)C.OB(O)c1ccsc1>>COC(=O)[C@@H](Cc1ccc(-c2ccsc2)cc1)NC(=O)OC(C)(C)C,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20140135292A1,CC(=O)c1nc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cn1COCC[Si](C)(C)C>>CC(=O)c1nc(CO)cn1COCC[Si](C)(C)C,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04044141,COC(=O)C1=C(C)NC(C)=C(C(=O)OCc2cccc(Cl)c2)C1c1cccc([N+](=O)[O-])c1>>C/C(N)=C/C(=O)OCc1cccc(Cl)c1,,c1ccncc1,,CCO,,val
US20150105373A1,COCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)cc1>>COC[C@@H](NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)cc1,,CCCCCC,CCO,,,val
US20090176804A1,COC(=O)Cc1c(-c2ccc(Cl)c(S(=O)(=O)NCCc3ccccc3OC)c2)[nH]c2ccccc12>>COc1ccccc1CCNS(=O)(=O)c1cc(-c2[nH]c3ccccc3c2CC(=O)O)ccc1Cl,,CO,O,[Li+].[OH-],,val
US04045499,C=C(C)C.CC(C)(c1ccc(O)cc1)c1ccc(O)cc1>>CC1(C)CC(C)(C)c2cc(O)ccc21,,Cc1ccccc1,,O=S(=O)(O)O,,val
US06511978B1,CC(C)(C)[Si](C)(C)Cl.COc1ccccc1CCn1cncc1CO>>COc1ccccc1CCn1cncc1CO[Si](C)(C)C(C)(C)C,,CN(C)C=O,,CO,ClCCl,val
US08664233B2,CCOc1nc(N2CCNCC2)nc2c1[nH]c1cc(Br)ccc12.O=C(Cl)C1CCN(C(=O)C(F)(F)F)CC1>>Oc1nc(C2CCNCC2)nc2c1[nH]c1cc(Br)ccc12,,ClCCl,c1ccncc1,O,,val
US06194410B1,CN1CCNCC1.CSc1nn2c(O)cc(CCl)nc2c1S(=O)(=O)c1ccccc1>>CSc1nn2c(O)cc(CN3CCN(C)CC3)nc2c1S(=O)(=O)c1ccccc1,,CN(C)C=O,,,,val
US05146002,C1CCOC1.CC(=O)C(C)(C)C.COC(=O)c1ccc(C(=O)OC)cc1>>CC(C)(C)C(=O)CC(=O)c1ccc(C(=O)CC(=O)C(C)(C)C)cc1,,C1CCOC1,,Cl,[H-].[Na+],val
US20100075964A1,CC(C)(O)c1cn(-c2ccc(-c3cccc(S(C)(=O)=O)c3)cc2)c(-c2c(Cl)cccc2Cl)n1>>C=C(C)c1cn(-c2ccc(-c3cccc(S(C)(=O)=O)c3)cc2)c(-c2c(Cl)cccc2Cl)n1,,CC(=O)O,,Cc1ccccc1,,val
US20070197617A1,COC(=O)[C@H](NC(=O)OC(C)(C)C)c1ccc(OCCO)cc1.CS(=O)(=O)Cl>>COC(=O)[C@H](NC(=O)OC(C)(C)C)c1ccc(OCCOS(C)(=O)=O)cc1,,c1ccncc1,,,,val
US20160075713A1,CC(C)(C)OC(=O)NC1CCNCC1.O=S(=O)(OCC(F)(F)c1ccc(Cl)cn1)C(F)(F)F>>CC(C)(C)OC(=O)NC1CCN(CC(F)(F)c2ccc(Cl)cn2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110245205A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1ccc2c(c1)CCC(=O)N2>>CC(C)(C)OC(=O)NCc1ccc2c(c1)CCC(=O)N2,,CO,,[BH4-].[Na+],,val
US04459302,CCc1ccccc1-c1nc(-c2cccc(OC)c2)n[nH]1.Cc1ccc(N=C=O)cc1>>CCc1ccccc1-c1nc(-c2cccc(OC)c2)nn1C(=O)Nc1ccc(C)cc1,,CC#N,,,,val
US20090221645A1,CCC(Br)C(=O)c1cccc2c(Cl)cccc12.S=C1NCCN1>>Br.CCC1=C(c2cccc3c(Cl)cccc23)N2CCN=C2S1,,CCO,,CC(=O)O,,val
US20120172345A1,NC(N)=S.O=C(CBr)Cc1ccc(Cl)cc1>>Nc1nc(Cc2ccc(Cl)cc2)cs1,,CCO,,,,val
US20150299179A1,C1CCNC1.CC(C)Oc1ccc(-c2nnc(-c3cccc4c3CCC[C@H]4N(CC(=O)O)C(=O)OC(C)(C)C)s2)cc1C#N>>CC(C)Oc1ccc(-c2nnc(-c3cccc4c3CCC[C@H]4N(CC(=O)N3CCCC3)C(=O)OC(C)(C)C)s2)cc1C#N,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US05246948,CN(C)NC(=O)Sc1cccnc1.O=C1c2ccccc2C(=O)N1CCCCBr>>O=C1c2ccccc2C(=O)N1CCCCSc1cccnc1,,CO,,[Na+].[OH-],,val
US04267318,Cc1cccc(C=NC2CCN(C(c3ccccc3)c3ccccc3)CC2)n1>>Cc1cccc(CNC2CCN(C(c3ccccc3)c3ccccc3)CC2)n1,,CCO,,[BH4-].[Na+],,val
US20090298824A1,COC(=O)c1cc(OC)cc(N)c1[N+](=O)[O-]>>COC(=O)c1cc(OC)cc(N)c1N,,CCO,,Cl[Sn]Cl,,val
US20120196874A1,CN(C)c1ccc(/C=C/c2c(F)cccc2F)c([N+](=O)[O-])c1>>CN(C)c1ccc(/C=C/c2c(F)cccc2F)c(N)c1,,CC(=O)O,Cl,Cl[Sn]Cl,,val
US20060205767A1,CC(=O)OC(C)=O.O.O=c1cc(-c2ccc(O)cc2)oc2ccccc12>>CC(=O)O.O=C(O)Cc1ccc(-c2cc(=O)c3ccccc3o2)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20100261698A1,CC(C)[Mg]Cl.CCOC(=O)C1(CNc2cncc(-c3cc4ccccc4n3C)c2)CCC1>>CC(C)C(=O)C1(CNc2cncc(-c3cc4ccccc4n3C)c2)CCC1,,C1CCOC1,,,,val
US20100125062A1,CCN(CC)S(F)(F)F.OC1(c2cccnc2Cl)CCOCC1>>FC1(c2cccnc2Cl)CCOCC1,CO,,,ClCCl,,val
US03974278,CCOC(=O)/C=C(/C)N.CCOCC(=O)CC(=O)OCC.O=Cc1ccccc1C(F)(F)F>>CCOCC1=C(C(=O)OCC)C(c2ccccc2C(F)(F)F)C(C(=O)OCC)=C(C)N1,,CCO,,,,val
US20150105373A1,Cc1cnc2c(c1)NC(=O)CN2C(=O)Oc1ccc([N+](=O)[O-])cc1.NC(CC1COC1)c1ccc(OC(F)(F)F)cc1>>Cc1cnc2c(c1)NC(=O)CN2C(=O)NC(CC1COC1)c1ccc(OC(F)(F)F)cc1,,CN(C)C=O,,CCN(CC)CC,O,val
US20060217387A1,Cc1cc(-c2cc(C(F)(F)F)n3nccc3n2)ccc1Cl.ClI>>Cc1cc(-c2cc(C(F)(F)F)n3ncc(I)c3n2)ccc1Cl,,CC(=O)O,O,CC(=O)[O-].[Na+],,val
US20080015199A1,COCCc1cc(Br)cc(OC)c1OC.O=CN1CCOCC1>>COCCc1cc(C=O)cc(OC)c1OC,,C1CCOC1,CCOC(C)=O,[Li]CCCC,[Cl-].[NH4+],val
US20120122940A1,CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CC)C(=O)OC(C)(C)C>>CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CC)C(=O)O,,ClCCl,,O,O=C(O)C(F)(F)F,val
US20100022583A1,C=C(C)CN(c1ccc(C(F)(F)F)cc1)c1cc(C)cc(Cl)n1.OB(O)c1ccc(C(F)(F)F)cc1>>C=C(C)CN(c1ccc(C(F)(F)F)cc1)c1cc(C)cc(-c2ccc(C(F)(F)F)cc2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US05556864,BrCC1CO1.N#Cc1ccccc1CCCCc1ccccc1O>>N#Cc1ccccc1CCCCc1ccccc1OCC1CO1,,CC(=O)N(C)C,,CC(C)(C)[O-].[K+],,val
US20090197871A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cc(C)cc(C(=O)NCc2cccc(-c3cccc(C=O)c3)c2)c1.C[C@H]1CNCCN1C(=O)OC(C)(C)C>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cc(C)cc(C(=O)NCc2cccc(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1,,CS(C)=O,,CC(=O)O,,val
US20040092737A1,COCOCCc1ccc(Br)cc1.O=C1CCN(Cc2ccccc2)CC1>>COCOCCc1ccc(C2(O)CCN(Cc3ccccc3)CC2)cc1,,C1CCOC1,CCCCCC,O,[Li]CCCC,val
US04416683,COc1cccc(OC)c1C(=O)O.O=S(Cl)Cl>>COc1cccc(OC)c1C(=O)Cl,,Cc1ccccc1,,,,val
US20020007071A1,C(=NC1CCCCC1)=NC1CCCCC1.Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCC(C)C(=O)O.NCc1ccccc1>>Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCC(C)C(=O)NNCc1ccccc1,,CN(C)C=O,,On1nnc2ccccc21,,val
US07855292B2,Nc1cc(I)ccc1C(=O)O.O=S(=O)(Cl)c1cccc2nccnc12>>O=C(O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12,,O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20080004285A1,Cc1cccc(N=C=O)c1.Clc1ccc2ncnc(N3CCNCC3)c2n1>>Cc1cccc(NC(=O)C2CNCCN2c2ncnc3ccc(Cl)nc23)c1,,ClCCl,,,,val
US04021554,C=CCN1CCNCC1.O=C(Oc1ccccc1)OC1C2=C(OCCS2)C(=O)N1c1ccc2ccc(Cl)nc2n1>>C=CCN1CCN(C(=O)OC2C3=C(OCCS3)C(=O)N2c2ccc3ccc(Cl)nc3n2)CC1,,CC#N,,CC(C)OC(C)C,,val
US06365736B1,CC1Oc2ccc(Cn3ccnc3)cc2NC1=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC1Oc2ccc(Cn3ccnc3)cc2NC1=S,,COCCOC,,,,val
US20020028831A1,CCOC(=O)c1ccc(-c2ccc(OC)c(-c3cccc([N+](=O)[O-])c3)c2)cc1>>COc1ccc(-c2ccc(C(=O)O)cc2)cc1-c1cccc([N+](=O)[O-])c1,,CCO,,Cl,[Na+].[OH-],val
US05705499,C#Cc1ccccc1.CCN1c2ncc(I)cc2C(=O)N(C)c2cccnc21>>CCN1c2ncc(C#Cc3ccccc3)cc2C(=O)N(C)c2cccnc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,CCN(CC)CC,,val
US20110257241A1,CCI.COC1(c2ccc(F)c(F)c2)CCNC1>>CCN1CCC(OC)(c2ccc(F)c(F)c2)C1,,C1CCOC1,,CCN(CC)CC,,val
US20160039794A1,Nc1cc(-c2ccc(N3CCOCC3)cc2)ccc1[N+](=O)[O-]>>Nc1ccc(-c2ccc(N3CCOCC3)cc2)cc1N,[Pd],CCO,CCOC(C)=O,,,val
US20100016373A1,Cn1cnc(C(=O)NCc2ccc(CO)cc2)c1.II>>Cn1cnc(C(=O)NCc2ccc(CI)cc2)c1,,ClCCl,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120101083A1,Cc1c(-c2noc(-c3cnc(NC(C)C)c(C#N)c3)n2)ccc2c1CCNC2.Cl.O=C[C@@H](O)CO>>Cc1c(-c2noc(-c3cnc(NC(C)C)c(C#N)c3)n2)ccc2c1CCN(C[C@@H](O)CO)C2.Cl,,CO,ClCCl,O=C([O-])O.[Na+],,val
US20120065210A1,CC(C)(C)C[C@@H]1N[C@@H](C(=O)Nc2ccc(C(=O)O)cc2OC(F)(F)F)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F.CN=C=O>>CN1C(=O)C2C(c3cccc(Cl)c3)C(C#N)(c3ccc(Cl)cc3)C(CC(C)(C)C)N2C1=O,O=S(=O)(O)O,C1CCOC1,,,,val
US20070265225A1,CC1(C)C(=O)C[C@@H](c2cc(F)cc(F)c2)N(CC(=O)O)C1=O.Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21>>CC1(C)C(=O)C[C@@H](c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C1=O,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20070208052A1,CC(Br)Cn1cccc1.CCCc1nc2c(N)nc3cc(OC(C)=O)ccc3c2s1>>CCCc1nc2c(N)nc3cc(OCCCn4cccc4)ccc3c2s1,,ClCCl,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20160158207A1,CC(CO)N(C)c1cc(Br)c(C(F)(F)F)cc1[N+](=O)[O-].O=S(Cl)Cl>>CC(CCl)N(C)c1cc(Br)c(C(F)(F)F)cc1[N+](=O)[O-],,ClCCl,,c1ccncc1,,val
US04410518,CCNP1(=S)OCC(C)(C)CO1.CNC(=O)ON=C(C)SC.O=S(Cl)Cl>>CCN(S(=O)CNC(=O)ON=C(C)SC)P1(=S)OCC(C)(C)CO1,,c1ccncc1,,,,val
US20110122475A1,COB(OC)OC.c1ccc(-c2cccs2)cc1>>OB(O)c1ccc(-c2ccccc2)s1,,C1CCOC1,,Cl,[Li]CCCC,val
US05192762,BrCC1CC2c3ccccc3C1c1ccccc12.CN1CCNCC1>>CN1CCN(Cc2cccc3c2C2CCC3c3ccccc32)CC1,,CN(C)P(=O)(N(C)C)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20020183341A1,C1=C(c2c[nH]c3ccccc23)CCNC1.CCOC(C)(OCC)OCC.Cc1ccc(S(=O)(=O)OC[C@H]2COc3ccc(N)c(C=NO)c3O2)cc1>>Cc1nc2ccc3c(c2c[n+]1[O-])OC(CN1CC=C(c2c[nH]c4ccccc24)CC1)CO3,,C1CCOC1,CN(C)C=O,O=C([O-])O.[Na+],,val
US20030186901A1,O=C(O)c1ccc(N2C(=O)c3ccc([N+](=O)[O-])cc3C2=O)cc1>>Nc1ccc2c(c1)C(=O)N(c1ccc(C(=O)O)cc1)C2=O,,C1COCCO1,,CC(=O)O,,val
US05231101,CS.O=C1C2=C(C=CCN2)CCc2cc(Cl)ccc21>>CSc1ccc2c(c1)CCC1=C(NCC=C1)C2=O,,CN(C)C=O,,[Na],,val
US20130172302A1,COC(=O)C(c1cccc(F)c1)N1CCCCC1.Cl>>Cl.O=C(O)C(c1cccc(F)c1)N1CCCCC1,,C1COCCO1,,,,val
US20100136136A1,CC1CN(C(=O)OC(C)(C)C)CCN1.O=[N+]([O-])c1ccc(F)cc1[N+](=O)[O-]>>CC1CN(C(=O)OC(C)(C)C)CCN1c1ccc([N+](=O)[O-])c([N+](=O)[O-])c1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US06423869B1,CC(C)C[C@H](N)C(=O)N[C@@H](CO)[C@@H](O)[C@@H](O)[C@H](O)C(=O)N[C@@H](CC(=O)O)c1ccccc1.O=C(Cl)OCc1ccccc1.[N-]=[N+]=C(c1ccccc1)c1ccccc1>>CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CO)[C@@H](O)[C@@H](O)[C@H](O)C(=O)N[C@@H](CC(=O)OC(c1ccccc1)c1ccccc1)c1ccccc1,,CO,O,Cl,O=C([O-])O.[Na+],val
US20060111375A1,COc1cc2c(Oc3cc4ccccc4nc3C)ccnc2cc1OCCCN1C(=O)c2ccccc2C1=O>>COc1cc2c(Oc3cc4ccccc4nc3C)ccnc2cc1OCCCN,,CN(C)C=O,,NN,,val
US05382600,CC(C)N(CCC(c1ccccc1)c1ccccc1O)C(C)C.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>CC(C)N(CCC(c1ccccc1)c1ccccc1O)C(C)C.O=C(O)[C@H](O)[C@@H](O)C(=O)O,,CCO,,,,val
US20100280043A1,CC(C)(C)OC(=O)CBr.COC(=O)CCc1ccc(Cl)cc1>>COC(=O)C(CC(=O)OC(C)(C)C)Cc1ccc(Cl)cc1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US06307056B1,Cc1ccc(B(O)O)cc1N.Cc1nc[nH]c1/C=C1\C(=O)Nc2ccc(F)c(I)c21>>Cc1ccc(-c2c(F)ccc3c2/C(=C/c2[nH]cnc2C)C(=O)N3)cc1N,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US04971993,O=C(OCc1ccccc1)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1.O=S(=O)(Cl)c1ccccc1>>O=C(OCc1ccccc1)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US20120077828A1,Nc1nccc2scc(-c3ccc4c(c3)CCN4)c12.O=C(O)Cc1cccc(C(F)(F)F)c1>>Nc1nccc2scc(-c3ccc4c(c3)CCN4C(=O)Cc3cccc(C(F)(F)F)c3)c12,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06265569B1,C#CCCCCCCI.NC(=O)C(F)(F)F>>C#CCCCCCCNC(=O)C(F)(F)F,,CCOCC,CN(C)C=O,[H-].[Na+],[Cl-].[NH4+],val
US20120071489A1,CCOC(=O)CC(=O)N1CCN(c2ccc(Cl)cc2C(C)(C)C)CC1>>CC(C)(C)c1cc(Cl)ccc1N1CCN(C(=O)CC(=O)O)CC1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20130317000A1,CS(=O)(=O)NC(=O)c1cc(Cl)c(CBr)cc1F.Oc1ccc2c(c1)CCCC2>>CS(=O)(=O)NC(=O)c1cc(Cl)c(COc2ccc3c(c2)CCCC3)cc1F,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150126490A1,Nc1ncc([C@@H]2CN[C@H](CO)C2)cc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1.O=C(n1ccnc1)n1ccnc1>>Nc1ncc([C@H]2C[C@H]3COC(=O)N3C2)cc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US04374962,Cc1cc(O)cc(O)c1.Cc1cccc(O)c1C=O>>C=O.Cc1cc(O)cc(O)c1.Cc1cccc(O)c1,,O,,O=C(O)C(=O)O,,val
US20060122387A1,CCN(CC)c1ccc2cc(C(N)=S)c(=O)oc2c1.O=C(c1ccccc1)C(Br)c1ccccc1>>CCN(CC)c1ccc2cc(-c3nc(-c4ccccc4)c(-c4ccccc4)s3)c(=O)oc2c1,,CCO,,,,val
US20150045378A1,COC(=O)C=Cc1cc(Cl)nc(C)n1.COc1ccc(F)c(-c2ccc(CO)nc2CC(C)(C)C)c1>>COc1ccc(F)c(-c2ccc(COc3cc(C=CC(=O)O)nc(C)n3)nc2CC(C)(C)C)c1,,C1CCOC1,,Cl,[H-].[Na+],val
US20080146607A1,CCCCI.COC(=O)C1CCCN1C(=O)OC(C)(C)C>>CCCCC1(C(=O)OC)CCCN1C(=O)OC(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20040063775A1,CCOC(=O)CCc1cc(O)nn1-c1ccccc1.Cc1oc(-c2ccccc2)nc1COc1ccc(CCl)cc1>>CCOC(=O)CCc1cc(OCc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)nn1-c1ccccc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050032786A1,CC(C)CCSc1cccc(-c2nc(=O)c3ccccc3s2)n1.O=C(OO)c1cccc(Cl)c1>>CC(C)CCS(=O)c1cccc(-c2nc(=O)c3ccccc3s2)n1,,ClC(Cl)Cl,,,,val
US04039543,COC(=O)c1cc([N+](=O)[O-])c(N(C)C(C)=O)c([N+](=O)[O-])c1>>COC(=O)c1cc(N)c(N(C)C(C)=O)c(N)c1,[Pd],CO,,,,val
US20100256097A1,CC(C)(O)c1cc(F)c(-c2cc(C(N)=O)c(Nc3ccc(=O)[nH]n3)s2)c(F)c1.COC(=O)CBr>>COC(=O)Cn1nc(Nc2sc(-c3c(F)cc(C(C)(C)O)cc3F)cc2C(N)=O)ccc1=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130274299A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C12CNCC1C2>>CCOC(=O)C12CC1CN(C(=O)OC(C)(C)C)C2,,CCO,,O=C([O-])O.[Na+],,val
US20100249099A1,COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N(CCCN2CCOCC2)C2CCCN(C(=O)OC(C)(C)C)C2)n1>>COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N(CCCN2CCOCC2)C2CCCNC2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050239768A1,NNc1ccccc1[N+](=O)[O-].O=C1CCNCC1>>O=[N+]([O-])c1cccc2c3c([nH]c12)CCNC3,,OCC(F)(F)F,,Cl,O,val
US06350907B1,COC[C@@H](N)c1ccccc1.COc1cccc(-c2ccc(CCCCCC[C@@H](C(=O)N[C@H](C(=O)O)C(C)(C)C)[C@@H]3OC(C)(C)OC3=O)cc2C)c1>>COC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCCCc1ccc(-c2cccc(OC)c2)c(C)c1)[C@@H]1OC(C)(C)OC1=O)C(C)(C)C)c1ccccc1,,CCOC(C)=O,,,,val
US20060100218A1,CCOc1cc([N+](=O)[O-])ccc1C(=O)n1cc(-c2ccc(OC)c(OC)c2)c2cccnc21>>CCOc1cc(N)ccc1C(=O)n1cc(-c2ccc(OC)c(OC)c2)c2cccnc21,[Pd],CCOC(C)=O,,,,val
US20020156076A1,CN(C)S(=O)(=O)n1c(C=O)cnc1[Si](C)(C)C(C)(C)C.CN(C)S(=O)(=O)n1c(Sc2ccccc2)cnc1[Si](C)(C)C(C)(C)C>>CN(C)S(=O)(=O)n1c(CC2CCCCC2)cnc1[Si](C)(C)C(C)(C)C,,C1CCOC1,,[Li]CCCC,,val
US05728848,OCC1CCOC2(CCCCC2)OC1>>OCCC1COC2(CCCCC2)OC1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20130331419A1,CCC(c1ccc(Cl)cc1)(n1ccc2c(NC(=O)OC(C)(C)C)cccc21)C1(O)CC1>>CCC(c1ccc(Cl)cc1)(n1ccc2c(N)cccc21)C1(O)CC1,,CO,Cl,,,val
US20110172209A1,BrC1CCCCCC1.c1ccc(COc2ccc3nc[nH]c3n2)cc1>>Oc1ccc2ncn(C3CCCCCC3)c2n1,,C1CCOC1,CCOCC,[H-].[Na+],,val
US20090286778A1,CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2Br)CC1.Cl.ClCCl>>Cl.Cl.O=[N+]([O-])c1ccc(N2CCNCC2)c(Br)c1,,ClCCl,,C1COCCO1,,val
US20150087663A1,C[C@H](N)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1.Cc1nnc(-c2c(N)ncnc2Cl)o1>>Cc1nnc(-c2c(N)ncnc2N[C@@H](C)c2nc3cccc(Cl)c3c(=O)n2-c2ccccc2)o1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20060074075A1,CC(C)(C#N)c1ccc([N+](=O)[O-])cc1>>CC(C)(CN)c1ccc([N+](=O)[O-])cc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20040138214A1,C/C=C/Cn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(CC(=O)c1ccccc1[N+](=O)[O-])c(=O)n2C>>C/C=C/Cn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(CC(=O)c1ccccc1N)c(=O)n2C,[Fe],CCO,,CC(=O)O,O,val
US08980916B2,Nc1ccc2c(N3C(=O)c4ccccc4C3=O)noc2c1.O=CO>>O=CNc1ccc2c(N3C(=O)c4ccccc4C3=O)noc2c1,,ClCCl,,CC(=O)OC(C)=O,,val
US20110015157A1,C=CC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(F)cc2)C(=O)O1.O=[O+][O-]>>C[C@@H](c1ccc(F)cc1)N1CC[C@](CC=O)(c2ccc(F)cc2)OC1=O,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06586617B1,CC(=O)OC(C)=O.COc1ccc(NS(=O)(=O)c2ccc(C)cc2)c([N+](=O)[O-])c1>>COc1ccc(N(C(C)=O)S(=O)(=O)c2ccc(C)cc2)c([N+](=O)[O-])c1,,CN(C)C=O,,O,[H-].[Na+],val
US20110165183A1,CCOC(=O)c1nccn1N.N=CN>>O=c1nc[nH]n2ccnc12,,CCO,,CC(=O)O,,val
US20160158207A1,CC(=O)N1CCc2[nH]nc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)c2C1.CS(=O)(=O)OC1CCC(F)(F)CC1>>CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCC(F)(F)CC2)C1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120053175A1,COc1cc(-c2cnc3[nH]ccc3c2)cc(OC)c1OC.O=C1CCC(=O)N1I>>COc1cc(-c2cnc3[nH]cc(I)c3c2)cc(OC)c1OC,,CC(C)=O,,,,val
US20050070542A1,CCC(CC)n1nc(C)c2nc(OS(=O)(=O)C(F)(F)F)c(C)nc21.OB(O)c1ccc(Cl)cc1Cl>>CCC(CC)n1nc(C)c2nc(-c3ccc(Cl)cc3Cl)c(C)nc21,,Cc1ccccc1,,,,val
US20090209607A1,CC(C)(C)N(CCC(c1ccccc1)N1C(=O)c2ccccc2C1=O)C(=O)[O-]>>CC(C)(C)OC(=O)NCCC(N)c1ccccc1,,C1CCOC1,CO,NN,,val
US20020016368A1,COc1ccccc1CCNS(C)(=O)=O>>CS(=O)(=O)NCCc1ccccc1O,,ClCCl,,BrB(Br)Br,,val
US20150105366A1,COc1nc2ccc(C(=O)c3ccc(C)nc3C)cc2c(Cl)c1Cc1ccc(F)cc1.Cc1ncc(Br)n1C>>COc1nc2ccc(C(O)(c3ccc(C)nc3C)c3cnc(C)n3C)cc2c(Cl)c1Cc1ccc(F)cc1,,C1CCOC1,,[Li]CCCC,,val
US20070219230A1,C=Cc1ccc(B(O)O)cc1.O=[N+]([O-])c1cccnc1Cl>>C=Cc1ccc(-c2ncccc2[N+](=O)[O-])cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20100273786A1,CC(C)(C)OC(=O)N[C@@H](CC(=O)N1CCn2c(C(F)(F)F)nc(C(=O)N3CCS(=O)(=O)CC3)c2C1)Cc1cc(F)c(F)cc1F.Cl>>Cl.N[C@@H](CC(=O)N1CCn2c(C(F)(F)F)nc(C(=O)N3CCS(=O)(=O)CC3)c2C1)Cc1cc(F)c(F)cc1F,,CCOC(C)=O,,,,val
US20120258952A1,CN1CCN(CCO)CC1.Cn1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(F)ccn45)cccc32)c1=O>>CN1CCN(CCOc2ccn3c(C(=O)Nc4cccc5c4c(C4CC4)nn5Cc4cccn(C)c4=O)cnc3c2)CC1,,O,,CC(C)(C)O,CC(C)(C)[O-].[K+],val
US20090137595A1,Nc1cccc(Sc2ccc3nc(NC(=O)C4CC4)cn3n2)c1.O=C(O)c1cccc(C(F)(F)F)c1>>O=C(Nc1cccc(Sc2ccc3nc(NC(=O)C4CC4)cn3n2)c1)c1cccc(C(F)(F)F)c1,CN(C)C=O,CC(=O)N(C)C,,C1CCOC1,O=C(Cl)C(=O)Cl,val
US20050009817A1,CCOC(=O)C1CCNCC1.C[Si](C)(C)CCOC(=O)CCC(=O)c1c[nH]c2ccc(Cl)cc12.ClCCl.N#Cc1cc([N+](=O)[O-])ccc1N>>CCOC(=O)C1CCN(c2nc(-n3cc(C(=O)CCC(=O)O)c4cc(Cl)ccc43)nc3ccc([N+](=O)[O-])cc23)CC1,,CO,ClCCl,Cl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20100168418A1,CC(C)(C)OC(=O)N(CC(=O)Nc1ccccn1)C1CCN(CCn2c(=O)cnc3ccccc32)CC1>>O=C(CNC1CCN(CCn2c(=O)cnc3ccccc32)CC1)Nc1ccccn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06127570,CC(=O)Oc1ccc(Br)c(C)c1C(=O)O.COc1cc(C)cc(OC)c1OC>>COc1cc(C)c(C(=O)c2c(OC(C)=O)ccc(Br)c2C)c(OC)c1OC,,ClCCl,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20110257196A1,COc1cc(Sc2cccc(-c3ccccc3)c2)cc(OC)c1OC.O=C(OO)c1cccc(Cl)c1>>COc1cc(S(=O)c2cccc(-c3ccccc3)c2)cc(OC)c1OC,,ClCCl,,,,val
US20050272784A1,NNc1cccc(C(F)(F)F)c1.O=C1COC(c2ccc(-c3ccccc3)cc2)=N1>>OCc1nc(-c2ccc(-c3ccccc3)cc2)nn1-c1cccc(C(F)(F)F)c1,,CCO,,,,val
US20040009983A1,Cc1ccc(S(=O)(=O)n2c(-c3cn(C)c4ccc(C5=CCN(C(=O)OCc6ccccc6)CC5)cc34)cc3cccnc32)cc1>>Cc1ccc(S(=O)(=O)n2c(-c3cn(C)c4ccc(-c5ccncc5)cc34)cc3cccnc32)cc1,[Pd],CCO,,[H][H],,val
US20130137679A1,BrCCCBr.Oc1ccc2scnc2c1>>BrCCCOc1ccc2scnc2c1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20150225390A1,CC(N)=O.O=C(O)c1ccc(C(=O)CBr)cc1>>Cc1nc(-c2ccc(C(=O)O)cc2)co1,,O,,,,val
US20060257987A1,COC(=O)CCc1ccc(OCC[C@@H](C)Oc2ccc(C3CC3)cc2C(=O)c2ccccc2)cc1C>>Cc1cc(OCC[C@@H](C)Oc2ccc(C3CC3)cc2C(=O)c2ccccc2)ccc1CCC(=O)O,,CO,,Cl,[Na+].[OH-],val
US20040077672A1,O=C1CC(c2c[nH]c3ccc(O)cc23)C(=O)N1>>O=C1C=C(c2c[nH]c3ccc(O)cc23)C(=O)N1,,CO,,,,val
US20080312226A1,O=C(Nc1nnc(N2CCOCC2)o1)OCC(Cl)(Cl)Cl.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>O=C(Nc1nnc(N2CCOCC2)o1)N1CCN(c2nc(-c3ccccc3)ns2)CC1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US20040054172A1,O=C1c2ccccc2C(=O)N1O.OCCCBr>>O=C1c2ccccc2C(=O)N1OCCCO,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20140163000A1,CC1(C)CN(c2ccncc2N)CCN1.CI>>CN1CCN(c2ccncc2N)CC1(C)C,,CN(C)C=O,,CO,[H-].[Na+],val
US20150307520A1,C=Cc1cn(COCC[Si](C)(C)C)c2ncnc(N3CCC[C@H]3c3nn4cccc4c(=O)n3-c3ccccc3)c12>>C=Cc1c[nH]c2ncnc(N3CCC[C@H]3c3nn4cccc4c(=O)n3-c3ccccc3)c12,,O=C(O)C(F)(F)F,,,,val
US20100143341A1,COC(=O)c1ccc([N+](=O)[O-])c(OC2CCOC2)c1>>COC(=O)c1ccc(N)c(OC2CCOC2)c1,[Pd],CCO,,,,val
US20100160255A1,CCN1C(=O)OC2(CCCN(C3CCN(C(=O)c4cc(-c5ccccn5)sc4NC(=O)OC(C)(C)C)CC3)C2)C1=O>>CCN1C(=O)OC2(CCCN(C3CCN(C(=O)c4cc(-c5ccccn5)sc4N)CC3)C2)C1=O,,O=C(O)C(F)(F)F,,O=C([O-])O.[Na+],,val
US20160024063A1,CC#CC(CC(=O)O)c1ccc(OCc2cccc(C3=CCC(O)CC3)c2)cc1.NCCCC[C@H](N)C(=O)O>>CC#CC(CC(=O)[O-])c1ccc(OCc2cccc(C3=CCC(O)CC3)c2)cc1.NCCCC[C@H](N)C(=O)O,,CCO,,,,val
US20070244125A1,CC(C)Br.O=C(c1ccc2[nH]c(C(=O)N3CCC(F)(F)CC3)cc2c1)N1CCC(N2CCCCC2)CC1>>CC(C)n1c(C(=O)N2CCC(F)(F)CC2)cc2cc(C(=O)N3CCC(N4CCCCC4)CC3)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20100048636A1,CN(C[C@@H](N)CC1CCCCC1)C(=O)OC(C)(C)C.CSC(=NC#N)SC>>CSC(=NC#N)N[C@@H](CC1CCCCC1)CN(C)C(=O)OC(C)(C)C,,CC#N,CCN(CC)CC,,,val
US20040087577A1,CC(C)(C)NS(=O)(=O)c1ccc(Cl)s1.Cc1ccc(S(=O)(=O)N=[N+]=[N-])cc1>>CC(C)(C)NS(=O)(=O)c1sc(Cl)cc1N=[N+]=[N-],,C1CCOC1,,[Li]C(C)CC,,val
US20110071150A1,Cc1ccccc1-c1cc2cc(Br)ccc2[nH]1.O=S(=O)(Cl)c1ccccc1>>Cc1ccccc1-c1cc2cc(Br)ccc2n1S(=O)(=O)c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20130116246A1,Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2C=O)cc(Nc2ccncn2)c1=O>>Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(Nc2ccncn2)c1=O,,CO,,[BH4-].[Na+],,val
US04436753,CC(=O)O.COc1cc(C)c(C(=O)CCCCCCCCCCCCCCCCCO)c(O)c1OC>>COc1cc(C)c(CCCCCCCCCCCCCCCCCCOC(C)=O)c(O)c1OC,[Pd],CCOCC,,[O-][Cl+3]([O-])([O-])O,,val
US20090054435A1,COc1ccc(C(=O)c2ccc(O)cc2)c(OC(C)(C)C(=O)OC(C)(C)C)c1.Cc1oc(-c2cccc(OS(C)(=O)=O)c2)nc1CCl>>COc1ccc(C(=O)c2ccc(OCc3nc(-c4cccc(OS(C)(=O)=O)c4)oc3C)cc2)c(OC(C)(C)C(=O)O)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04925838,CN1CCN(C(=O)[C@@H]2C[C@@H](OS(C)(=O)=O)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)C1=O>>CN1CCN(C[C@@H]2C[C@@H](OS(C)(=O)=O)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)C1=O,,C1CCOC1,CCOC(C)=O,CO,,val
US20040073025A1,NC1CC1.O=C(CBr)NCc1cc(Cl)ccc1-n1cnnn1>>O=C(CNC1CC1)NCc1cc(Cl)ccc1-n1cnnn1,,ClCCl,,,,val
US20120264737A1,CCc1cc(C2CCC2)c(I)cc1C(=O)OC>>CCc1cc(C2CCC2)c(I)cc1C(=O)O,,CO,O,[Na+].[OH-],,val
US06548494B1,CN.O=Cc1cccc(-c2cc3c4c(ccn4C(=O)CNC3)c2)c1>>CNCc1cccc(-c2cc3c4c(ccn4C(=O)CNC3)c2)c1,,O,,,,val
US20150307473A1,CC(C)(C)OC(=O)N1CC(=O)C1.Cc1cccc(F)n1>>CC(C)(C)OC(=O)N1CC(O)(Cc2cccc(F)n2)C1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20130150577A1,Fc1ccccc1F.O=C(Cl)CCCl>>O=C(CCCl)c1ccc(F)c(F)c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130172559A1,CCCC[C@H](N)CCNCC(C)C.COC(=O)c1c(OCc2ccccc2)c(=O)c(C(=O)NCc2ccc(F)cc2)cn1CC=O>>CC(C)C[C@H]1CCN(CC(C)C)[C@@H]2Cn3cc(C(=O)NCc4ccc(F)cc4)c(=O)c(OCc4ccccc4)c3C(=O)N12,,ClCCl,,CC(=O)O,,val
US20130090323A1,CC(C)Oc1ccc(B(O)O)cc1F.Nc1cc(Cl)ncc1Br>>CC(C)Oc1ccc(-c2cnc(Cl)cc2N)cc1F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20130158038A1,CCOC(=O)Cc1nc(-c2ccc(F)cc2)cn1-c1ccc(F)cc1.COc1ccnc(N2CCNCC2)c1>>COc1ccnc(N2CCN(C(=O)Cc3nc(-c4ccc(F)cc4)cn3-c3ccc(F)cc3)CC2)c1,,CN1CCCC1=O,,O,,val
US05110815,Cn1c2c(ccc1=O)C(=O)CCC2.NCCc1ccc(C(F)(F)F)cc1>>Cn1c2c(ccc1=O)C(NCCc1ccc(C(F)(F)F)cc1)CCC2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04558059,CCOC(=O)c1sc(-c2ccccc2OC)nc1C.CN>>CNC(=O)c1sc(-c2ccccc2OC)nc1C,,CCO,,,,val
US20110275797A1,CC(=O)Oc1ccc(OCc2ccccc2)c(C(=O)Nc2cc(-c3ccccc3)ccc2C(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)c1ccc(-c2ccccc2)cc1NC(=O)c1cc(O)ccc1OCc1ccccc1,,C1COCCO1,CO,[Na+].[OH-],,val
US20100121048A1,CC(Cl)OC(=O)Cl.Cc1cc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2Cc2ccccc2)c(-c2ccccc2)n1-c1cccc(N2CCSCC2)c1.ClCCCl>>Cc1cc(C(=O)N2CCNC[C@H]2Cc2ccccc2)c(-c2ccccc2)n1-c1cccc(N2CCSCC2)c1.Cl.Cl,,ClCCCl,,,,val
US20050020587A1,CC(C)C(=O)N1CCC(N)C1.CSc1cccc(Oc2ncc(F)cc2C(=O)O)c1>>CSc1cccc(Oc2ncc(F)cc2C(=O)NC2CCN(C(C)=O)C2)c1,CN(C)c1ccncc1,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20150119362A1,CCOC(=O)Cc1ccc(Nc2cc(N3CCN(C(=O)OC(C)(C)C)CC3)nc3c2CCC3)cc1.N>>CC(C)(C)OC(=O)N1CCN(c2cc(Nc3ccc(CC(N)=O)cc3)c3c(n2)CCC3)CC1,,CO,,,,val
US20110034452A1,COCCOc1cc(C(=O)OC)cc(C(C)(C)C)c1>>COCCOc1cc(C(=O)O)cc(C(C)(C)C)c1,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US05945426,C[Mg]Br.Clc1nc(Cl)nc(-c2ccccc2)n1>>Cc1nc(Cl)nc(-c2ccccc2)n1,,C1CCOC1,,O,,val
US20140315888A1,CN1CCN(c2nc(NN)c3cc(Cl)cnc3n2)CC1.COC(OC)OC>>CN1CCN(c2nc3ncc(Cl)cc3c3nncn23)CC1,,CCOCC,,,,val
US20130338142A1,Brc1cn2ccnc2c(Br)n1.CC(C)(C)OC(=O)N1CCC(c2ccc(N)cc2)CC1>>CC(C)(C)OC(=O)N1CCC(c2ccc(Nc3nc(Br)cn4ccnc34)cc2)CC1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US03974144,Cc1ccc(-c2cc3ccccc3o2)cc1.O=Cc1ccc(C(=O)O)cc1>>O=C(O)c1ccc(C=Cc2ccc(-c3cc4ccccc4o3)cc2)cc1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US04971959,COC(=O)CCc1ccc(OC)c(OC2CCCC2)c1>>COc1ccc(CCC(=O)O)cc1OC1CCCC1,,CO,O,[K+].[OH-],,val
US20010037037A1,COc1ccc(C(C#N)=NO)cc1OC.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1ccc(C(C#N)=NOS(=O)(=O)c2ccc(C)cc2)cc1OC,,C1CCOC1,,CCN(CC)CC,,val
US20120208817A1,CC(C)(C)[Si](C)(C)Cl.CCCc1cc(C(=O)OCC)cc([N+](=O)[O-])c1O>>CCCc1cc(C(=O)OCC)cc([N+](=O)[O-])c1O[Si](C)(C)C(C)(C)C,,CN(C)C=O,,c1c[nH]cn1,,val
US20100056508A1,O=C(Cl)OCc1ccccc1.O=C(OCc1ccccc1)N(CCC(=O)N(CCNCCc1ccc(OCc2ccccc2)c([N+](=O)[O-])c1)C1CCCCC1)CCc1ccccc1>>O=C(OCc1ccccc1)N(CCC(=O)N(CCN(CCc1ccc(OCc2ccccc2)c([N+](=O)[O-])c1)C(=O)OCc1ccccc1)C1CCCCC1)CCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20120095216A1,COc1ccc(CN2CCCOC(C)C2=O)cc1>>COc1ccc(CN2CCCOC(C)C2)cc1,,C1CCOC1,,CO,[Na+].[OH-],val
US20040072822A1,COc1ccccc1N1CCN(CCC(C(=O)C2CCCCC2)c2ccccc2)CC1>>COc1ccccc1N1CCN(CCC(c2ccccc2)C(O)C2CCCCC2)CC1,,Cc1ccccc1,ClCCl,CC(C)C[Al+]CC(C)C.[H-],,val
US20120065233A1,Cc1c2c(cc3[nH]c(-c4c(NC(C)Cc5c(F)c(F)cc(F)c5F)cc[nH]c4=O)nc13)C(=O)N(C1CCN(C)CC1)C2=O>>Cc1c2c(cc3[nH]c(-c4c(NC(C)Cc5c(F)c(F)cc(F)c5F)cc[nH]c4=O)nc13)CN(C1CCN(C)CC1)C2=O,[Zn],CC(=O)O,,,,val
US20110065681A1,CCCC[Sn](CCCC)(CCCC)c1ccc(C)cn1.Cc1ncc(CNC(=O)c2cc(Br)cc(C(=O)N3CCCC3)c2)cn1>>Cc1ccc(-c2cc(C(=O)NCc3cnc(C)nc3)cc(C(=O)N3CCCC3)c2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,Cc1ccccc1,,val
US20140357661A1,COC(=O)/C=C/c1ccc([C@H]2N[C@H](C)Cc3c2[nH]c2ccccc32)cc1.C[C@H](CF)COS(=O)(=O)C(F)(F)F>>COC(=O)/C=C/c1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@@H](C)N2C[C@H](C)CF)cc1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20100093730A1,CCOC(=O)C(CCC#N)c1ccccc1>>O=C1NCCCC1c1ccccc1,[Ni],CO,N,,,val
US20150038510A1,CC(C)(C)O.O=C(O)c1cccc(Cl)c1Br.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)Nc1cccc(Cl)c1Br,,Cc1ccccc1,,CCN(CC)CC,,val
US20150315198A1,CC(=O)Nc1nc(C)c(C#N)cc1C#C[Si](C)(C)C>>Cc1nc2[nH]ccc2cc1C#N,,O,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20050153970A1,Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN(CCCc2ccc(F)cc2)C(=O)OC(C)(C)C)c1>>Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CNCCCc2ccc(F)cc2)c1,,C1COCCO1,,Cl,,val
US20090186886A1,CCN(CC)CCN.[O-][n+]1nc(Cl)nc2cc3c(cc21)CCC3>>CCN(CC)CCNc1nc2cc3c(cc2[n+]([O-])n1)CCC3,,COCCOC,,,,val
US06391064B1,Cn1cccc1.O=C1C(Cl)=CC(=O)c2ncccc21>>Cn1cccc1C1=C(Cl)C(=O)c2cccnc2C1=O,,CC(=O)O,,,,val
US20130237571A1,CC#CC(CC(=O)OC)c1ccc(OCc2ccccc2)cc1>>CCCC(CC(=O)OC)c1ccc(O)cc1,[Pd],CCOC(C)=O,,c1ccc2ncccc2c1,,val
US05294721,CCOC(=O)CCl.c1ccncc1>>CCOC(=O)C[n+]1ccccc1.[Cl-],,CCOC(C)=O,,,,val
US20110313002A1,COc1cccc2c1CC1=C(O2)C(=O)N([C@@H](CC2CCCCC2)C(=O)O)C1.Nc1ccccn1>>COc1cccc2c1CC1=C(O2)C(=O)N([C@@H](CC2CCCCC2)C(=O)Nc2ccccn2)C1,,ClCCl,O,O=C(Cl)C(=O)Cl,,val
US20140323468A1,N#Cc1ccc2c(n1)NCCC2.O=C1CCC(=O)N1Br>>N#Cc1nc2c(cc1Br)CCCN2,,ClCCl,,,,val
US20070197581A1,CS(=O)(=O)OCC1COc2c(F)ccc(F)c2C1S(=O)(=O)c1ccc(Cl)cc1.OCCS>>O=S(=O)(c1ccc(Cl)cc1)C1c2c(F)ccc(F)c2OCC1CSCCO,,CO,,[Na+].[OH-],,val
US20150307451A1,COC(=O)c1cc(Cc2ccc(OC)cc2)c(C)c(Cl)c1O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1cc(Cc2ccc(OC)cc2)c(C)c(Cl)c1OS(=O)(=O)C(F)(F)F,,CN(C)C=O,,Cl,[H-].[Na+],val
US04163759,O=C(O)C(O)c1ccc(O)cc1>>O=Cc1ccc(O)cc1,,O,,O=C=O,,val
US20150225405A1,[N-]=[N+]=Nc1cc(Cl)ccc1-c1ccnn1C1CCCCO1>>Clc1ccc2c(c1)[nH]c1cnn(C3CCCCO3)c12,,Clc1ccccc1Cl,,,,val
US20110003738A1,Brc1ccc2c3c([nH]c2c1)CC1CCCN1C3.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)n2c3c(c4ccc(Br)cc42)CN2CCCC2C3)cc1,,C1CCOC1,,[H-].[Na+],,val
US20100048636A1,CN.CS(=O)(=O)OCC(CC12CCC(CC1)CC2)NC(=O)OCc1ccccc1>>CNCC(CC12CCC(CC1)CC2)NC(=O)OCc1ccccc1,,CO,,,,val
US20130090323A1,Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)ncc1I.OB(O)c1ccc(C(F)(F)F)nc1>>Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)ncc1-c1ccc(C(F)(F)F)nc1,,C1COCCO1,O,C1CCC(P(C2CCCCC2)C2CCCCC2)CC1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20020045780A1,CCCCCC.CI.Cc1cc(C)c(S(=O)(=O)NCCCCCN(CCCCNS(=O)(=O)c2c(C)cc(C)cc2C)S(=O)(=O)c2c(C)cc(C)cc2C)c(C)c1>>CCN(CCCCCN(CCCCN(C)S(=O)(=O)c1c(C)cc(C)cc1C)S(=O)(=O)c1c(C)cc(C)cc1C)S(=O)(=O)c1c(C)cc(C)cc1C,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20140303186A1,COC(=O)Cc1n[nH]c2ncccc12.O=[N+]([O-])c1ccc(CBr)cc1>>COC(=O)Cc1nn(Cc2ccc([N+](=O)[O-])cc2)c2ncccc12,,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150218165A1,CC(C)(C)OC(=O)N1CCC(C=O)CC1.CO>>C#CC1CCN(C(=O)OC(C)(C)C)CC1,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US05824661,CCOP(=O)(Cl)OCC.COP(=O)(CC(C)C)OC>>CCOP(=O)(OCC)C(C(C)C)P(=O)(OC)OC,,C1CCOC1,,[Li]C(C)CC,,val
US20150291597A1,C#CCN.Clc1nc(Cl)nc(Cl)n1.NCc1ccc(F)cc1>>C#CCNc1nc(Cl)nc(NCc2ccc(F)cc2)n1,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20160115161A1,CC(C)(C)OC(=O)N1CCC(C(=O)OCI)CC1.Cc1ccc(NC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1Cl>>Cc1ccc(NC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)N(COC(=O)C4CCN(C(=O)OC(C)(C)C)CC4)C2=O)C3=O)cc1Cl,,CN(C)C=O,,[H-].[Na+],,val
US20070232583A1,CC(C)(C)COS(=O)(=O)c1cccc(Br)c1.CC(C)OB(OC(C)C)OC(C)C>>CC(C)(C)COS(=O)(=O)c1cccc(B(O)O)c1,,C1CCOC1,,[Li]CCCC,,val
US05212178,CCCN1C[C@@H](N)C[C@@H]2c3cccc4[nH]c(C)c(c34)C[C@H]21.COCC(=O)Cl>>CCCN1C[C@@H](NC(=O)COC)C[C@@H]2c3cccc4[nH]c(C)c(c34)C[C@H]21,,c1ccncc1,,N,,val
US20090131438A1,CCn1c(S)nnc1[C@@H](C)NC(=O)OC(C)(C)C.CI>>CCn1c(SC)nnc1[C@@H](C)NC(=O)OC(C)(C)C,,C1CCOC1,,CC(C)NC(C)C,,val
US20040209920A1,C=CCBr.O[C@@H]1CCC[C@H](OCc2ccccc2)C1>>C=CCO[C@@H]1CCC[C@H](OCc2ccccc2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20090181928A1,Nc1ccccc1NC(=O)/C=C/c1ccc(N2CC(=O)NS2(=O)=O)c(OCc2ccccc2)c1>>O=C1CN(c2ccc(/C=C/c3nc4ccccc4[nH]3)cc2OCc2ccccc2)S(=O)(=O)N1,,CC(=O)O,,,,val
US20060041123A1,COc1ccc2ncc(Cl)c(CCN3CCC(NC(=O)OC(C)(C)C)CC3)c2c1>>COc1ccc2ncc(Cl)c(CCN3CCC(N)CC3)c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100087418A1,CC(=O)c1ccccc1-c1cccc2c1OCCN(C(=O)OC(C)(C)C)C2.Cl>>CC(=O)c1ccccc1-c1cccc2c1OCCNC2.Cl,,CCOC(C)=O,,,,val
US20130150361A1,CC(C)c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(O[Si](C(C)C)(C(C)C)C(C)C)c4)c4ccccc43)cn12>>CC(C)c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(O)c4)c4ccccc43)cn12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20060167040A1,CS(=O)(=O)c1nccc(-c2cc3cn[nH]c3nc2-c2cccc(C(F)(F)F)c2)n1.NCC1CC1>>FC(F)(F)c1cccc(-c2nc3[nH]ncc3cc2-c2ccnc(NCC3CC3)n2)c1,,C1CCOC1,,,,val
US20030191122A1,CCN(C(C)C)C(C)C.Cc1nc(Cl)c2c(C)cn(-c3c(C(C)C)csc3C)c2n1.NC(=O)C1=CCNCC1.O=C(O)C(F)(F)F>>CSc1cc(C(C)C)ccc1-n1cc(C)c2c(N3CC=C(C(N)=O)CC3)nc(C)nc21,,CCO,,O=C([O-])O.[Na+],,val
US20150352253A1,CC(=O)N(CC(O)CN(C(C)=O)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I.CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I>>CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I.CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I,,O,,[Ca+2].[Cl-].[Cl-],,val
US20140315888A1,CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc(C(F)(F)F)cc3nc2NN)C1.COC(OC)OC>>CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc(C(F)(F)F)cc3n3cnnc23)C1,,CCOCC,,,,val
US05268377,CCc1ncc[nH]1.CN(C)S(=O)(=O)Cl>>CCc1nccn1S(=O)(=O)N(C)C,,ClC(Cl)Cl,,CCN(CC)CC,O,val
US20140155264A1,Nc1c(Br)cc(Cl)cc1C(=O)O.O=C(Cl)Cl>>O=c1[nH]c2c(Br)cc(Cl)cc2c(=O)o1,,C1COCCO1,,,,val
US05922727,CCc1c(Sc2ccccc2)[nH]c(=O)[nH]c1=O.Cc1ccccc1S(=O)(=O)OCC1CC=CC1>>CCc1c(Sc2ccccc2)n(CC2CC=CC2)c(=O)[nH]c1=O,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20140088094A1,O=[N+]([O-])c1ccc(F)c(NS(=O)(=O)c2ccc(F)cc2)c1.OC[C@H]1CO1>>O=[N+]([O-])c1ccc2c(c1)N(S(=O)(=O)c1ccc(F)cc1)C[C@H](CO)O2,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US06458781B1,CC(C)CC(C(=O)O)N1CCOCC1.Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1>>CC(C)C[C@@H](C(=O)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)N1CCOCC1,,CCOCC,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140228443A1,CCCC(CCC)C(=O)Nc1cccc(/C=C/CNC(=O)OC(C)(C)C)c1>>CCCC(CCC)C(=O)Nc1cccc(CCCNC(=O)OC(C)(C)C)c1,,CCO,,,,val
US05144015,CC(C)(C)C(Cl)=C(C#N)C#N.NN>>CC(C)(C)c1n[nH]c(N)c1C#N,,CCO,,,,val
US20150119385A1,CC(C)(C)[Si](OC1CCNc2nc(Br)ccc21)(c1ccccc1)c1ccccc1.CN(C)C=O>>CC(C)(C)[Si](OC1CCNc2nc(C=O)ccc21)(c1ccccc1)c1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US03933839,Nc1nnc(C2CCCCCC2)s1.O=C(Cl)Cl>>O=C=Nc1nnc(C2CCCCCC2)s1,,CCOC(C)=O,,,,val
US06762205B1,NS(=O)(=O)Cl.O=[N+]([O-])c1ccccc1-c1ccc(O)cc1>>NS(=O)(=O)Oc1ccc(-c2ccccc2[N+](=O)[O-])cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20100190747A1,Nc1ccc(OCC2CC2)cc1.S=C(Cl)Cl>>S=C=Nc1ccc(OCC2CC2)cc1,,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20060280746A1,COc1ccc(C(/C=C/c2c(OC)cc(OC)cc2OC)S(=O)C(/C=C/c2c(OC)cc(OC)cc2OC)c2ccc(OC)cc2)cc1.OO>>COc1ccc(C(/C=C/c2c(OC)cc(OC)cc2OC)S(=O)(=O)C(/C=C/c2c(OC)cc(OC)cc2OC)c2ccc(OC)cc2)cc1,,CC(=O)O,,,,val
US05091387,Cc1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1>>Cc1ccc(S(=O)(=O)N2CCC3(CCc4ccccc43)CC2)cc1,[Pd],CCO,,,,val
US20100048658A1,CNc1c(N)cccc1N.O=C(O)Cc1c(Cl)cc(C(F)(F)F)cc1Cl>>Cn1c(Cc2c(Cl)cc(C(F)(F)F)cc2Cl)nc2cccc(N)c21,,Cc1ccccc1,,,,val
US05554614,O=C(Cl)c1ccccc1.O=C1c2ccccc2C(=O)N1CCN1CCN(c2n[nH]c3cc(F)ccc23)CC1>>Cl.O=C1c2ccccc2C(=O)N1CCN1CCN(c2nn(C(=O)c3ccccc3)c3cc(F)ccc23)CC1,,CCOCC,,CCO,,val
US20100130466A1,Cc1ccc(C(C)NC(=O)OC(C)(C)C)cn1.II>>Cc1cc(I)c(C(C)NC(=O)OC(C)(C)C)cn1,,C1CCOC1,,[Li]C(C)(C)C,,val
US05348964,C1CCNCC1.CC(C)CCSCCCCl.Cl>>CC(C)CCSCCCN1CCCCC1.Cl,,CCOCC,,,,val
US20090233937A1,O=[N+]([O-])c1ccc(F)c(Cl)c1.Oc1cccc2nscc12>>Nc1ccc(Oc2cccc3nscc23)c(Cl)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04689071,CN1CC(O)N(c2cc(C(C)(C)C)on2)C1=O.OCS>>CSC1CN(C)C(=O)N1c1cc(C(C)(C)C)on1,,CC(C)(C)O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110136764A1,CCOP(=O)(OCC)C(C)(C)c1ccc([N+](=O)[O-])cc1>>CCOP(=O)(OCC)C(C)(C)c1ccc(N)cc1,[Pd],CO,,,,val
US20110015073A1,CSSC.O=C(O)c1ccc(C(F)(F)F)c(F)c1>>CSc1c(C(=O)O)ccc(C(F)(F)F)c1F,,C1CCOC1,,Cl,[Li]CCCC,val
US04504415,CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)O>>CC(C)C[C@H](N)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)O,[Pd],CO,,O,,val
US20080009479A1,CC(C)(C)OC(=O)N1CCc2ccc(O)cc2CC1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.Oc1ccc2c(c1)CCNCC2,,ClCCl,,,,val
US20140256713A1,CCOC(=O)c1ncc(Cc2ccccc2)cc1N.O=CC(=O)O>>CCOC(=O)c1ncc(Cc2ccccc2)cc1NCC(=O)O,,CCO,,O,[BH3-]C#N.[Na+],val
US20140329799A1,COc1nc(N2CCOCC2)nc(N[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)c1-c1nc2cc(Br)ccc2s1>>O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2cc(Br)ccc2s1,,CC#N,,Cl,O,val
US20120040954A1,CC(C)(C)[Si](C)(C)OCCBr.O=Cc1cccc(O)c1>>CC(C)(C)[Si](C)(C)OCCOc1cccc(C=O)c1,,CN(C)C=O,O,[H-].[Na+],,val
US20120041213A1,O=C1CCC(=O)N1Cl.Oc1ccc(C2CCOCC2)c(O)c1>>Oc1cc(O)c(C2CCOCC2)cc1Cl,,ClCCl,,,,val
US20020165203A1,Clc1ncc(Cl)c(Cl)n1.c1c[nH]cn1>>Clc1cc(Cl)nc(-c2ncc[nH]2)n1,,C1CCOC1,,CCN(CC)CC,[Cl-].[NH4+],val
US20090264429A1,ON=C(c1ccc(Br)cc1F)C(F)(F)F>>FC(F)(F)c1noc2cc(Br)ccc12,,ClCCl,,C1CCOC1,,val
US20150126721A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.Cc1ccc(SC2O[C@H](CO)[C@@H](OCc3ccc4ccccc4c3)[C@H](O)[C@H]2N=[N+]=[N-])cc1>>Cc1ccc(SC2O[C@H](CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)[C@@H](OCc3ccc4ccccc4c3)[C@H](O)[C@H]2N=[N+]=[N-])cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20030158219A1,CCOC(=O)C#N.O=C1CCc2ccccc2N1>>CCOC(=O)C1Cc2ccccc2N(C)C1=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20080319031A1,CC(C)(C)OC(=O)NC(Cc1ccc(Oc2ccc(C=C3C(=O)Nc4ccccc43)cc2)cc1)C(=O)O.CNC>>CN(C)C(=O)C(Cc1ccc(Oc2ccc(C=C3C(=O)Nc4ccccc43)cc2)cc1)NC(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20080045555A1,CCCCCNc1nc[nH]c1C(N)=S.CI>>CCCCCNc1nc[nH]c1C(=N)SC,,CC(C)=O,,,,val
US20120165331A1,COC(=O)C1(CCC#N)CCN(C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N1CCC2(CCCNC2=O)C1,[Ni],CO,,N,,val
US20020035094A1,Cc1cc(Cl)ccc1Oc1ccc(N)cn1.O=C(Cl)c1ccccc1>>Cc1cc(Cl)ccc1Oc1ccc(NC(=O)c2ccccc2)cn1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20020028832A1,CC(C)(C)[Si](Oc1ccc(OC[C@@H](O)CNCCc2ccc(NC3CCN(C(=O)c4c[nH]c5ccccc45)CC3)cc2)cc1)(c1ccccc1)c1ccccc1>>O=C(c1c[nH]c2ccccc12)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1,,CO,ClC(Cl)Cl,,,val
US06015925,CC(C)(C)C#CC=CCBr.CNCc1ccccc1-c1ccccc1>>CN(C/C=C\C#CC(C)(C)C)Cc1ccccc1-c1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20090275542A1,C[C@H]1C[C@H]2[C@@H]3CCC(=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)CC12.Cl.NO[C@@H]1CCNC1>>C[C@H]1C[C@H]2[C@@H]3CCC(=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=NO[C@@H]3CCNC3)CC12.Cl,,O,,Cl,,val
US20030036651A1,CO.N#CCOC(=O)CCCC=Cc1ccccn1>>COC(=O)CCCC=Cc1ccccn1,,CO,,CCN(CC)CC,,val
US20010046975A1,CCN(CC)C(=O)c1ccccc1NC(C)(C)C.CI>>CCN(CC)C(=O)c1ccccc1N(C)C(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040171606A1,CC(=O)OC(C)=O.c1ccc2c(c1)CCNCC2>>CC(=O)N1CCc2ccccc2CC1,,ClCCl,,CCN(CC)CC,O,val
US20150353553A1,CC(C)=O.Fc1ccc(Cl)nc1>>CC(C)(O)c1cc(Cl)ncc1F,,C1CCOC1,,[Li]CCCC,,val
US20130267510A1,CC(=O)OC(C)=O.Oc1cccc(O)c1Br>>CC(=O)Oc1cccc(O)c1Br,,ClCCl,,,,val
US06096736,CCOC(C)=O.CN(C)C=O.COC(=O)CC1CCCN(C(=O)c2ccc(N)cc2Cl)c2ccccc21>>CCCNc1ccc(C(=O)N2CCCC(CC(=O)OC)c3ccccc32)c(Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20120245026A1,CN(C)N1CCC(N)(C#N)CC1.Cc1cc(C)c(CC(=O)Cl)c(C)c1>>Cc1cc(C)c(CC(=O)NC2(C#N)CCN(N(C)C)CC2)c(C)c1,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20100016319A1,C1COCCN1.COc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2ccnc(Cl)n2)c1>>COc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2ccnc(N3CCOCC3)n2)c1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US04368325,CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CCS[C@H]12)C(=O)C(Br)Br.NC(N)=S>>CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CCS[C@H]12)c1csc(N)n1,,C1CCOC1,O,Cl,CC(=O)[O-].[Na+],val
US20130281490A1,CCOC(=O)[C@H]([C@H](O)CC)N(Cc1ccccc1)Cc1ccccc1>>CCOC(=O)[C@@H](N)[C@H](O)CC,[Pd],CCO,,,,val
US20160185785A1,COc1cccc(-n2ncc3c(=O)n(CC4(O)CCN(C(=O)C5(C)CC5)CC4)cnc32)c1>>CC1(C(=O)N2CCC(O)(Cn3cnc4c(cnn4-c4cccc(O)c4)c3=O)CC2)CC1,,ClCCl,,BrB(Br)Br,,val
US06077866,CSCc1ccc(C(=O)c2ccc(Cl)cc2)cc1.NN>>CSCc1ccc(C(=NN)c2ccc(Cl)cc2)cc1,,CC(=O)O,,CCO,O,val
US05763489,CCOC(=O)CBr.OCC1CCCc2c(O)cccc21>>CCOC(=O)COc1cccc2c1CCCC2CO,,CC#N,,[I-].[K+],,val
US20150152095A1,COc1c(Nc2ncc(C#N)s2)nc(N2CCC[C@H]2c2ccc(C)cc2)nc1OS(=O)(=O)C(F)(F)F.Cc1ncc(B2OC(C)(C)C(C)(C)O2)cn1>>COc1c(Nc2ncc(C#N)s2)nc(N2CCC[C@H]2c2ccc(C)cc2)nc1-c1cnc(C)nc1,,CCOC(C)=O,O,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US06713471B1,CC(C)I.Oc1ccc(Br)c(Cl)c1>>CC(C)Oc1ccc(Br)c(Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040259910A1,CCOC(=O)c1cnc(C(=O)c2cccc(OC(C)C)c2)c2cc(OC)c(O)cc12.CN(C)C(=O)CCl>>CCOC(=O)c1cnc(C(=O)c2cccc(OC(C)C)c2)c2cc(OC)c(OCC(=O)N(C)C)cc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130237525A1,CCOC(=O)C(C)CC(NS(=O)C(C)(C)C)c1c(OC)cccc1OC>>CCOC(=O)C(C)CC(N)c1c(OC)cccc1OC,,CO,,C1COCCO1,Cl,val
US20120208791A1,Cc1cnnc(-c2ccn3ccnc3c2)n1.NC(=O)CCC(=O)NI>>Cc1cnnc(-c2ccn3c(I)cnc3c2)n1,,CN(C)C=O,,CCOCC,,val
US20150329523A1,C#C[Si](C(C)C)(C(C)C)C(C)C.COc1cc(N)cc(Br)c1>>COc1cc(N)cc(C#C[Si](C(C)C)(C(C)C)C(C)C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20090227622A1,CC(C)(C)c1cc(NC(=O)NCc2ccc(-c3cnc4cc(-c5ccc(S(C)(=O)=O)cc5)ccn34)cc2)n(CCO)n1.CS(=O)(=O)Cl>>CC(C)(C)c1cc(NC(=O)NCc2ccc(-c3cnc4cc(-c5ccc(S(C)(=O)=O)cc5)ccn34)cc2)n(CCOS(C)(=O)=O)n1,,ClCCl,,CCN(CC)CC,,val
US20160031891A1,CC(C)(C)OC(=O)N1CC[C@@H](n2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)ncnc32)C1.Cl>>Cl.Nc1ncnc2c1c(-c1ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc1)nn2[C@@H]1CCNC1,,CO,,C1COCCO1,,val
US20030191135A1,CC1(C(=O)Cl)CCCCC1.N[C@H](CC1CCCCC1)CN1CCN(c2ccccc2O)CC1>>CC1(C(=O)N[C@H](CC2CCCCC2)CN2CCN(c3ccccc3O)CC2)CCCCC1,,CCN(CC)CC,,,,val
US20040138277A1,CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccc(C)cc1.Cc1ccc(S(=O)(=O)OCCc2nc(-c3cccc(-c4ccccc4)c3)oc2C)cc1>>Cc1ccc(OC(C)(Cc2ccc(OCCc3nc(-c4cccc(-c5ccccc5)c4)oc3C)cc2)C(=O)O)cc1,,CCO,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US05385925,CCCCc1nc2ccc(N(C)S(=O)(=O)c3ccc(Cl)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCCc1nc2ccc(N(C)S(=O)(=O)c3ccc(Cl)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05223498,Nc1ccccc1N1CCCCC1.S=C(Cl)Cl>>S=C=Nc1ccccc1N1CCCCC1,,C1COCCO1,,O,,val
US20120183660A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O[C@@H]1CO[C@@H]2[C@H](O)CO[C@H]12>>O=S(=O)(O[C@@H]1CO[C@@H]2[C@H](OS(=O)(=O)C(F)(F)F)CO[C@H]12)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US20150210677A1,NC1=C(O)C(=O)C(c2ccc(Cl)cc2Cl)O1.O=S(=O)(Cl)Cc1ccccc1>>NC1=C(OS(=O)(=O)Cc2ccccc2)C(=O)C(c2ccc(Cl)cc2Cl)O1,,C1CCOC1,,CCN(CC)CC,[Cl-].[NH4+],val
US20060135566A1,CSc1ccc(-c2nc(-c3cccc(C)c3)c(-c3ccnc(F)c3)s2)cc1.O=C(OO)c1cccc(Cl)c1>>Cc1cccc(-c2nc(-c3ccc(S(C)(=O)=O)cc3)sc2-c2ccnc(F)c2)c1,,CN(C)C=O,,[Na+].[OH-],,val
US20150065705A1,Cc1ccc(S(=O)(=O)OCc2ccc(C(F)(F)F)s2)cc1.O=c1nc(N2CCN(c3ccc(F)cc3)CC2)nc[nH]1>>O=c1nc(N2CCN(c3ccc(F)cc3)CC2)ncn1Cc1ccc(C(F)(F)F)s1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20030078251A1,CC(=O)Cl.COc1cccc([C@H]2O[C@H](CC(=O)N[C@@H](C)C(=O)O)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC>>COc1cccc([C@H]2O[C@H](CC(=O)N[C@@H](C)C(=O)O)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC,,O,,CCOC(C)=O,c1ccncc1,val
US06528656B1,CC1=CCCN1.CCO[PH](C)=O>>CCO[PH](=O)CC1(C)CCCN1,,ClCCl,,CCN(CC)CC,C[Si](C)(C)Cl,val
US05036067,CC(=O)c1ccc2c(c1)Sc1ccccc1O2.NO>>CC(=NO)c1ccc2c(c1)Sc1ccccc1O2,,c1ccncc1,,CCO,Cl,val
US20120283239A1,Fc1ccccn1.OCCC1CNC1>>OCCC1CN(c2ccccn2)C1,,ClCCl,,CCN(CC)CC,CO,val
US20100173933A1,COc1ccc(-c2csc(COc3ccc(F)c(C(N)=O)c3F)n2)cc1>>NC(=O)c1c(F)ccc(OCc2nc(-c3ccc(O)cc3)cs2)c1F,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US05576334,CCCCS(=O)(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)OC(C)(C)C>>CCCCS(=O)(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)OC(C)(C)C,[Pd],CO,,O=C[O-].[NH4+],,val
US20150336979A1,C#Cc1ccc2c(c1)OCO2.CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@H](OS(=O)(=O)C(F)(F)F)CO[C@H]12>>CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@@H](C#Cc3ccc4c(c3)OCO4)CO[C@H]12,,C1CCOC1,CN(C)P(=O)(N(C)C)N(C)C,[Li]CCCC,,val
US20070232583A1,CNC1CC1.Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(=O)(=O)Cl)c3)n2)n1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(=O)(=O)N(C)C4CC4)c3)n2)n1,,C1CCOC1,CCOC(C)=O,,,val
US20050187236A1,CNC(=O)n1ccc2cc(Oc3ccnc(N)c3)ccc21.O=C(Cl)Oc1ccccc1>>CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)Oc4ccccc4)c3)ccc21,,CN(C)C=O,,CCN(CC)CC,c1ccncc1,val
US20100190769A1,CCOC(=O)c1nc(C)sc1N.O=C=NS(=O)(=O)Cl>>CCOC(=O)c1nc(C)sc1NC(N)=O,,ClCCl,,,,val
US20160002248A1,CC(C)CN.CCOC(=O)c1nnc(CCCCc2cc3cc(Cc4ccccc4)[nH]c3nn2)s1>>CC(C)CNC(=O)c1nnc(CCCCc2cc3cc(Cc4ccccc4)[nH]c3nn2)s1,,CO,,,,val
US20020115674A1,C1CNCCN1.CCn1c(=O)n(O)c(=O)c2cc(F)c(F)cc21>>CCn1c(=O)n(O)c(=O)c2cc(F)c(N3CCNCC3)cc21,,CC#N,,CCN(CC)CC,,val
US06069145,CCCC(=O)OC[C@H]1CO1.COCCN1CCN(c2ccc(NC(=O)OCc3ccccc3)cc2F)CC1=O>>COCCN1CCN(c2ccc(N3C[C@H](CO)OC3=O)cc2F)CC1=O,,C1CCOC1,CN1CCCN(C)C1=O,[Li]CCCC,O=C([O-])O.[Na+],val
US20060058361A1,BrBr.Oc1ccc2occc2c1>>Oc1ccc2occc2c1Br,,CO,,O=C([O-])O.[Na+],,val
US20110263575A1,CC[C@@H](N[C@@H]1CCC(F)(F)C1)C(=O)OC(C)(C)C.CO>>CC[C@@H](N[C@@H]1CCC(F)(F)C1)C(=O)OC,,CO,,Cl,,val
US20090170847A1,Cc1ccnc(N)c1N.O=C(O)c1ccc(F)cc1F>>Cc1ccnc2[nH]c(-c3ccc(F)cc3F)nc12,,O,,[Na+].[OH-],,val
US20120157430A1,CC(=O)c1cc(Cl)c(F)c(I)c1O.CI>>COc1c(C(C)=O)cc(Cl)c(F)c1I,,CCOCC,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US06603008B1,CC(=O)c1ccc([N+](=O)[O-])c(C(F)(F)F)c1>>CC(=O)c1ccc(N)c(C(F)(F)F)c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20050014788A1,C=CC(C)(c1ccccc1)c1ccc(C(=O)OC)cc1.O=O>>COC(=O)c1ccc(C(CC=O)c2ccccc2)cc1,,CO,,CSC,,val
US20150166564A1,CC(C)(C)OC(=O)N[C@H]1CN(Cc2ccccc2)C[C@@H]1c1ccc(Cl)c(F)c1>>CC(C)(C)OC(=O)N[C@H]1CNC[C@@H]1c1cccc(F)c1,[Pd],CO,,,,val
US04016166,COS(=O)OC.O=c1[nH]c(=O)n(-c2cccc([N+](=O)[O-])c2)c2ccccc12>>Cn1c(=O)c2ccccc2n(-c2cccc([N+](=O)[O-])c2)c1=O,,O,,CN(C)C=O,[H-].[Na+],val
US20100130495A1,CC(=O)N1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(OS(=O)(=O)C(F)(F)F)c2C1.Nc1cccc(CO)c1>>CC(=O)N1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(Nc3cccc(CO)c3)c2C1,,CS(C)=O,,,,val
US06372764B1,CCCS.CCOC(=O)[C@H]1CN(Cc2ccccc2)C[C@H]1C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1>>CCCC(=S)[C@@H]1CN(Cc2ccccc2)C[C@H]1C(=O)OCC,,C1CCOC1,,[Li]CCCC,,val
US20150005282A1,CC(=O)OCc1cc(O[C@@H]2CCOC2)cc(C)c1-c1cccc(CO)c1.COC(=O)C[C@@H]1COc2cc(O)ccc21>>COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)cc(O[C@@H]5CCOC5)cc4COC(C)=O)c3)ccc21,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060004018A1,Cc1cc(C(F)(F)F)cc(N2CCN(C(=O)[C@@]3(C(C)C)CC[C@@H](NC(=O)OC(C)(C)C)C3)CC2)n1>>Cc1cc(C(F)(F)F)cc(N2CCNCC2)n1,,Cl,ClCCl,C1COCCO1,,val
US20040260088A1,COc1c(O)cccc1C=O.N#Cc1ccc(Br)cc1F>>COc1c(C=O)cccc1Oc1cc(Br)ccc1C#N,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20090181942A1,CCOC(=O)CNC(=O)CC1CCN(C(=O)CC[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3cccc32)CC1>>COc1cccc([C@H]2O[C@H](CCC(=O)N3CCC(CC(=O)NCC(=O)O)CC3)c3cccn3-c3ccc(Cl)cc32)c1OC,,CO,,,,val
US20050192302A1,CC(C)(C)OC(=O)CBr.OCc1cc(C(F)(F)F)ccn1>>O=C(O)COCc1cc(C(F)(F)F)ccn1,,CN(C)C=O,,O,[H-].[Na+],val
US20160176843A1,COC(=O)c1ccccc1CN(CCc1ccc(Cl)cc1)C1CCN(c2nnc(N)[nH]2)CC1>>Nc1n[nH]c(N2CCC(N(CCc3ccc(Cl)cc3)Cc3ccccc3C(=O)O)CC2)n1,,CO,,Cl,[Na+].[OH-],val
US20070173507A1,Cc1coc2cc(O)ccc2c1=O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1coc2cc(OS(=O)(=O)C(F)(F)F)ccc2c1=O,,O,,c1ccncc1,,val
US04630896,CCC[C@@H]1CC[C@@H](CC[C@H]2CC[C@H](C#N)CC2)CC1.O=S(=O)(O)O>>CCC[C@H]1CC[C@H](CC[C@H]2CC[C@H](C=O)CC2)CC1,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US05268389,CC(C)O.CC(C)OC(=O)c1cc(N=C=O)ccc1Cl>>CC(C)OC(=O)Nc1ccc(Cl)c(C(=O)OC(C)C)c1,CCN(CC)CC,C1CCOC1,,,,val
US20080108631A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=S.CCC(=O)CBr>>CCc1csc([C@@H](N)Cc2ccc([N+](=O)[O-])cc2)n1,,CC#N,,CCOCC,,val
US04931083,CC(Oc1ncn(-c2ccc(Br)cc2)n1)C(=O)O.CCCN.O=C(n1ccnc1)n1ccnc1>>CC(Oc1ncn(-c2ccc(Br)cc2)n1)C(=O)N1CCCC1,,CN(C)C=O,,,,val
US04221914,Cc1ccc(S(=O)(=O)n2c(CC(=O)O)cnc2C(C)C)cc1.O=C(Cl)C(=O)Cl>>Cc1ccc(S(=O)(=O)n2c(CC(=O)Cl)cnc2C(C)C)cc1,,c1ccccc1,,[Na],,val
US20110144098A1,C[C@@](N)(c1cc([N+](=O)[O-])ccc1F)C1(C(=O)O)CC1>>C[C@@](N)(c1cc([N+](=O)[O-])ccc1F)C1(CO)CC1,,C1CCOC1,,Cl,,val
US20100249163A1,COCCc1ccc(Cl)c(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(OC)c2ccc(F)c(F)c2)C2CC2)c1>>COCCc1ccc(Cl)c(CN(C(=O)C2CNCCC2(OC)c2ccc(F)c(F)c2)C2CC2)c1,,ClCCl,,Cl,,val
US06320051B1,COc1cc(Cl)nc2ccccc12.NCCCCN>>COc1cc(NCCCCN)nc2ccccc12,,ClCCl,,,,val
US06124283,CN1CCN(c2cccc3c2C[C@H](N)CC3)CC1.O=C(Cl)C1CCCCC1>>CN1CCN(c2cccc3c2C[C@H](NC(=O)C2CCCCC2)CC3)CC1,,ClCCl,,CCN(CC)CC,,val
US20100197654A1,CC(C)(C)OC(=O)N1CC[C@H]1C(=O)Nc1cnccn1>>O=C(Nc1cnccn1)[C@@H]1CCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150299214A1,C=[N+]=[N-].Cc1ccccc1Nc1c(C(=O)O)cnc(Cl)c1C>>COC(=O)c1cnc(Cl)c(C)c1Nc1ccccc1C,,C1CCOC1,,CC(=O)O,,val
US20160108047A1,CI.Cc1cc([N+](=O)[O-])cnc1O>>Cc1cc([N+](=O)[O-])cn(C)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04783462,CC(C)(C)n1ncc(NCCCO)c(Cl)c1=O.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCCCNc2cnn(C(C)(C)C)c(=O)c2Cl)cc1,,c1ccncc1,,ClCCl,,val
US20080045506A1,CC(C)(C)OC(=O)N1CC[C@H](C(=O)O)C1.CC(C)N1CCNCC1>>CC(C)N1CCN(C(=O)[C@H]2CCN(C(=O)OC(C)(C)C)C2)CC1,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20100029633A1,CCc1ccnc(N)c1.O=CCCl>>CCc1ccn2ccnc2c1,,CCO,,,,val
US20070027126A1,CS(=O)(=O)Cl.Cn1c(C#N)ccc1-c1cc(F)c(N)cc1F>>Cn1c(C#N)ccc1-c1cc(F)c(NS(C)(=O)=O)cc1F,,CCOC(C)=O,c1ccncc1,O,,val
US04279918,CCOC(=O)Cc1ccc([N+](=O)[O-])cc1.CCOC1(OCC)CCCN1C>>CCOC(=O)C(=C1CCCN1C)c1ccc([N+](=O)[O-])cc1,,c1ccccc1,,,,val
US20100113409A1,CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cccc(O)c2)C1.Cl>>CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cccc(O)c2)C1.Cl,,CO,,,,val
US20050137171A1,COP(=O)(Oc1ccc2c(c1)c(-c1cccn1C(=O)OC(C)(C)C)nn2C(=O)OC(C)(C)C)c1ccccc1>>COP(=O)(Oc1ccc2[nH]nc(-c3ccc[nH]3)c2c1)c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100105740A1,COc1cc(CNC(C)=O)c(Br)cc1OCCO.Cl>>COc1cc(CN)c(Br)cc1OCCO.Cl,,CCO,,,,val
US20130123528A1,CC(C)N1C=CN(C(C)C)[SiH]1Cl.N>>CC(C)N1C=CN(C(C)C)[SiH]1N,,CCCCCC,,,,val
US04284644,COC(=O)c1cc(Cl)c(NC(C)=O)cc1O.O=C1OCCC1Br>>COC(=O)c1cc(Cl)c(NC(C)=O)cc1OC1CCOC1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160122344A1,CCOC(=O)C(=CN(C)C)C(C)=O.CCOc1cc2c(cc1OCC)CC(COC(C)=O)N=C2>>CCOC(=O)C1=CN2C(COC(C)=O)Cc3cc(OCC)c(OCC)cc3C2CC1=O,,CS(C)=O,,C1COCCO1,Cl,val
US06057315,CCCc1c(O)cc2oc3cc(Cl)cn3c(=O)c2c1O>>CCCc1c(O)cc2oc3cccn3c(=O)c2c1O,[Ni],CCOC(C)=O,CO,[K+].[OH-],,val
US20070032515A1,COc1cc(-c2c(C)n[nH]c2N)ccc1OCC1CCN(C(=O)OC(C)(C)C)CC1.O=C(O)C(F)(F)F.O=Cc1ccc(O)cc1>>COc1cc2c(cc1OCC1CCNCC1)c(-c1ccc(O)cc1)nc1[nH]nc(C)c12.O=C(O)C(F)(F)F,,CN(C)C=O,,,,val
US20100022513A1,CC(C)(NC(=O)OCc1ccccc1)C(=O)O.Nc1nc(-c2ccc(F)cc2)c(Oc2ccc(F)cc2)s1>>CC(C)(NC(=O)OCc1ccccc1)C(=O)Nc1nc(-c2ccc(F)cc2)c(Oc2ccc(F)cc2)s1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120129806A1,CC(=O)N[C@@]1(C(=O)NC(C)(C)C)CNC[C@@H]1CCCB1OC(C)(C)C(C)(C)O1.CN1CCCCC1CO>>CN1CCCCC1CN1C[C@H](CCCB(O)O)[C@](N)(C(=O)O)C1,,CC#N,,CCN(C(C)C)C(C)C,CS(=O)(=O)Cl,val
US20150361039A1,Cc1cc(S(=O)(=O)Cl)ccc1F.Cc1ccc(NCC(C)C)c(C)c1>>Cc1ccc(N(CC(C)C)S(=O)(=O)c2ccc(F)c(C)c2)c(C)c1,,c1ccncc1,,,,val
US20070082912A1,CCOC(=O)c1cncc(-n2c(C)ccc2-c2ccccc2OCc2ccccc2)c1>>Cc1ccc(-c2ccccc2OCc2ccccc2)n1-c1cncc(C(=O)O)c1,,CCOC(C)=O,,CCO,[Na+].[OH-],val
US20020133045A1,CCCc1ccc(OC)cc1.N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O>>COc1ccc(C=CC=O)cc1,,ClC(Cl)Cl,,C1COCCO1,,val
US04975431,Cc1cc2c(nc1Br)CCCCC2.O=Cc1cccc(Cl)c1>>Cc1cc2c(nc1C(O)c1cccc(Cl)c1)CCCCC2,,CCCCCC,Cc1ccccc1,O,[Li]CCCC,val
US20060025400A1,CC(C)(C)[Si](OCCc1ncc2c(n1)CCCC2N=[N+]=[N-])(c1ccccc1)c1ccccc1>>CC(C)(C)[Si](OCCc1ncc2c(n1)CCCC2N)(c1ccccc1)c1ccccc1,[Pd],CCOC(C)=O,CO,,,val
US20060229302A1,CCc1c[nH]c2c(N)cc(C(=O)OC)cc12.O=S(=O)(Cl)CCl>>CCc1c[nH]c2c(NS(=O)(=O)CCl)cc(C(=O)OC)cc12,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US05252593,Cc1ccc(O)c(C=O)c1.N#Cc1ccccc1CBr>>Cc1ccc2oc(-c3ccccc3C#N)cc2c1,,CCO,CN(C)C=O,C[O-].[Na+],,val
US20120129890A1,CCI.O=Cc1cc(O)ccc1[N+](=O)[O-]>>CCOc1ccc([N+](=O)[O-])c(C=O)c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US06096766,CC(=O)Nc1ccc(O)c(C(C)=O)c1.CI>>COc1ccc(NC(C)=O)cc1C(C)=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100311966A1,CO[C@@H]1CNCC[C@@H]1NC(=O)OCc1ccccc1.S=C(n1ccnc1)n1ccnc1>>CO[C@@H]1CN(C(=S)n2ccnc2)CC[C@@H]1NC(=O)OCc1ccccc1,,C1CCOC1,,Cl,,val
US20100160255A1,CC(C)(C)OC(=O)Nc1sc(-c2ccc(C#N)cc2)cc1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1>>CC1(C)CC2(CCCN(C3CCN(C(=O)c4cc(-c5ccc(C#N)cc5)sc4N)CC3)C2)C(=O)O1,,O=C(O)C(F)(F)F,,O=C([O-])O.[Na+],,val
US20130158025A1,CCOC(=O)CC(=O)c1ccc(F)cc1.Cc1ccc(-c2c(C)n[nH]c2N)cc1>>Cc1ccc(-c2c(C)nn3c(-c4ccc(F)cc4)cc(=O)[nH]c23)cc1,,c1ccncc1,,,,val
US06117873,CCN(Cc1cc([N+](=O)[O-])cc2nc(OC)c(OC)nc12)[C@@H](C)P(=O)(OC)OC>>CCN(Cc1cc([N+](=O)[O-])cc2[nH]c(=O)c(=O)[nH]c12)[C@@H](C)P(=O)(O)O,,Cl,,,,val
US20090181959A1,C=CC#N.Cc1nn(-c2ccnc3[nH]ccc23)cc1Br>>Cc1nn(-c2ccnc3[nH]ccc23)cc1/C=C/C#N,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,,CCN(CC)CC,CN(C)C=O,val
US03997591,CN(CCCl)c1ccc(Cl)cc1C(=O)c1ccccc1.NCCCO>>CN1CCN2CCCOC2(c2ccccc2)c2cc(Cl)ccc21,,CCO,,CCN(CC)CC,,val
US20110275515A1,CCc1ccc(-c2ccc(Cl)cc2)cc1C(O)c1ccco1>>CCc1ccc(-c2ccc(Cl)cc2)cc1C1C(=O)C=CC1O,,O,,CC(C)=O,,val
US20030162783A1,CC(C)(C)OC(=O)NN(Cc1cc2ccccc2s1)C(=O)c1c(C(=O)N2CCCC2)[nH]c2cc(Cl)ccc2c1=O>>O=c1c2ccc(Cl)cc2[nH]c2c(O)nn(Cc3cc4ccccc4s3)c(=O)c12,,C1CCOC1,,CS(=O)(=O)O,,val
US04262008,CCCCCC(CCN1C(=O)C(C(=O)OCC)C(=O)C1CC(=O)OCC)OCc1ccccc1>>CCCCCC(CCN1C(=O)CC(=O)C1CC(=O)OCC)OCc1ccccc1,,CCOCC,,O=S(=O)([O-])[O-].[Mg+2],,val
US20020045615A1,C=O.COc1ccc(N2CCNCC2)c2sc(NC(=O)c3ccc(C)s3)nc12>>COc1ccc(N2CCN(C)CC2)c2sc(NC(=O)c3ccc(C)s3)nc12,,CO,,O=CO,,val
US20030158163A1,COS(=O)(=O)OC.Cc1cnc(C(=O)O[C@]2(C(=O)O)[C@H](C)CC3C4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]45O[C@H]5C[C@@]32C)cn1>>COC(=O)[C@@]1(OC(=O)c2cnc(C)cn2)[C@H](C)CC2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]34O[C@H]4C[C@@]21C,,CN(C)C=O,,C1CCC2=NCCCN2CC1,O,val
US06534546B1,COc1ccc(N)cc1CNC(=O)OC(C)(C)C.CSC(=N)N[N+](=O)[O-]>>COc1ccc(NC(N)=N[N+](=O)[O-])cc1CNC(=O)OC(C)(C)C,,CO,,CC#N,CCN(CC)CC,val
US20100029608A1,CON.O=Cc1ccc(Br)s1.c1ccncc1>>CO/N=C\c1cnc(Br)s1,,ClCCl,,Cl,,val
US20080090840A1,CCC(Br)COc1ccc([C@H](CC(=O)N2C(=O)OC[C@@H]2Cc2ccccc2)c2ccon2)cc1.Oc1ccc(C(F)(F)F)cc1>>CCC(COc1ccc([C@H](CC(=O)N2C(=O)OC[C@@H]2Cc2ccccc2)c2ccon2)cc1)Oc1ccc(C(F)(F)F)cc1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080081907A1,COc1ccccc1CNc1ccc2c(C#N)cccc2n1.NO>>COc1ccccc1CNc1ccc2c(C(=N)NO)cccc2n1,,CCO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20060025459A1,CO.O=C(O)c1cc([N+](=O)[O-])c(Cl)c([N+](=O)[O-])c1>>COc1c([N+](=O)[O-])cc(C(=O)O)cc1[N+](=O)[O-],,O,,[K+].[OH-],,val
US20080009530A1,CCOC(C)=O.COCCOc1ccc(/C=C/CO)c(Oc2ncc(C(F)(F)F)cc2Cl)c1.O=C=NS(=O)(=O)c1ccc(Cl)cc1>>COCCOc1ccc(/C=C/COC(=O)NS(=O)(=O)c2ccc(Cl)cc2)c(Oc2ncc(C(F)(F)F)cc2Cl)c1.O.O,,CC#N,CCOC(C)=O,CCN(C(C)C)C(C)C,Cl,val
US20090247502A1,COC(=O)c1cnc2c(c1)N(S(=O)(=O)Cl)CCO2.FC(F)(F)C1CCNCC1>>COC(=O)c1cnc2c(c1)N(S(=O)(=O)N1CCC(C(F)(F)F)CC1)CCO2,,ClCCl,,Cl,,val
US06004977,Br.COc1ccc2c(c1F)CN(Nc1ccncc1)C2>>Br.Oc1ccc2c(c1F)CN(Nc1ccncc1)C2,,O,,,,val
US20160176858A1,Cc1oc([C@@H]2CC[C@@H](C)N(C(O)c3ccccc3-n3nccn3)C2)nc1CO>>Cc1oc([C@@H]2CC[C@@H](C)N(C(=O)c3ccccc3-n3nccn3)C2)nc1C=O,,ClCCl,O,,,val
US20090291940A1,CCc1c(C(=O)OCc2ccccc2)c(O)nc2ccccc12>>CCc1c(C(=O)O)c(O)nc2ccccc12,[Pd],C1CCOC1,CO,,,val
US20130274243A1,CC(C)(C)OC(=O)N[C@@H](CCCOCc1ccccc1)c1nc2cc(C(C)(C)C)ccc2[nH]1>>CC(C)(C)c1ccc2[nH]c([C@@H](N)CCCO)nc2c1,[Pd],CCOC(C)=O,,,,val
US20060235021A1,CCCC[Sn](CCCC)(CCCC)c1ccncc1.Fc1ccc(-c2cnnc(Cl)c2)cc1-c1ncccc1F>>Fc1ccc(-c2cnnc(-c3ccncc3)c2)cc1-c1ncccc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,ClCCl,,,val
US20150329506A1,CON(C)C(=O)c1conc1C.C[Mg]Br>>CC(=O)c1conc1C,,C1CCOC1,,Cl,,val
US20070232627A1,CC(C)(C)c1ccc(S)cc1.O=C(Nc1ccc(F)c([N+](=O)[O-])c1)c1cccc(C(F)(F)F)c1>>CC(C)(C)c1ccc(Sc2ccc(NC(=O)c3cccc(C(F)(F)F)c3)cc2[N+](=O)[O-])cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100113520A1,CC(=O)c1ccc(N)cc1.COc1ccc(CN(C(=O)c2cnc(Br)s2)c2ccc(F)cc2F)cc1>>COc1ccc(CN(C(=O)c2cnc(Nc3ccc(C(C)=O)cc3)s2)c2ccc(F)cc2F)cc1,,C1CCOC1,,[H-].[Na+],,val
US20040138286A1,CC1(C)CC[C@H](O)C[C@@H]1C#N.Cc1c(O)ccc2[nH]ncc12>>Cc1c(O[C@@H]2CCC(C)(C)[C@@H](C#N)C2)ccc2[nH]ncc12,,Cc1ccccc1,,CCCCP(=CC#N)(CCCC)CCCC,,val
US20010008893A1,Cc1cc(O)cc(C)c1O.O=C(Cl)c1ccccc1>>Cc1cc(OC(=O)c2ccccc2)cc(C)c1O,,c1ccncc1,,,,val
US06407096B1,COC(=O)CBr.OCCc1coc2c(O)cccc12>>COC(=O)COc1cccc2c1OCC2CCO,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090062251A1,COC(=O)c1ccc(N)c(Cl)c1.O=C1CCC1>>COC(=O)c1ccc(NC2CCC2)c(Cl)c1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4cnc5cc[nH]c5c4)nc(Cl)c3n2)cc1.Nc1ccc2c(c1)NC(=O)CC2>>O=C1CCc2ccc(Nc3nc(-c4cnc5cc[nH]c5c4)nc4cn[nH]c34)cc2N1,C1COCCO1,CO,,Cl,,val
US05578596,ClCCCBr.Oc1cnc2c(n1)CCCC2>>ClCCCOc1cnc2c(n1)CCCC2,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130029961A1,CCOC(=O)C(C)c1cnc([N+](=O)[O-])c(F)c1>>CCOC(=O)C(C)c1cnc(N)c(F)c1,[Pd],CCO,,[H][H],,val
US20150218093A1,CCS.COc1cc(N2CCC(Oc3ccc(-c4ccccc4)cc3)C2=O)ccc1OC[C@H]1CO1>>CCSC[C@@H](O)COc1ccc(N2CCC(Oc3ccc(-c4ccccc4)cc3)C2=O)cc1OC,,C1CCOC1,ClCCl,[K+].[OH-],,val
US04564386,CC(=O)Cl.Cc1cc(S(=O)(=O)N(C)C)ccc1NS(=O)(=O)C(F)(F)F>>CC(=O)N(c1ccc(S(=O)(=O)N(C)C)cc1C)S(=O)(=O)C(F)(F)F,,C1CCOC1,,CCN(CC)CC,,val
US04698093,CCOC(=O)c1c(C(F)F)nc(C(F)(F)F)c(C(=O)OCC)c1N>>CCOC(=O)c1c(C(F)(F)F)nc(C(F)F)c(C(=O)O)c1N,,CCO,,Cl,[Na+].[OH-],val
US20030199440A1,CC(C)(C)OC(=O)[C@H](N)C(C)(C)C.O=S(=O)(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>CC(C)(C)OC(=O)[C@H](NS(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1)C(C)(C)C,,ClCCl,,CCN(CC)CC,Cl,val
US20100234389A1,CC(C)(C)OC(=O)N1CCN(c2cccc(Br)c2)CC1.OB(O)c1ccc(F)cc1F>>CC(C)(C)OC(=O)N1CCN(c2cccc(-c3ccc(F)cc3F)c2)CC1,,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20160184318A1,CC(C)(C)OC(=O)N1CCC(C(=O)CBr)CC1.CC(N)=O>>Cc1nc(C2CCNCC2)co1,,CCOC(C)=O,,,,val
US20140018313A1,CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2ccc(Br)cc2)[nH]1.COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3cc(B4OC(C)(C)C(C)(C)O4)ccc3c2)[nH]1)[C@@H](C)OC(F)F>>COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3cc(-c4ccc(-c5cnc([C@@H]6CCCN6C(=O)OC(C)(C)C)[nH]5)cc4)ccc3c2)[nH]1)[C@@H](C)OC(F)F,,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20070037802A1,CN.Cc1ccc(S(=O)(=O)OCCOc2ccc3c(c2)c(S(=O)(=O)c2cccc4ccccc24)nn3C)cc1>>CNCCOc1ccc2c(c1)c(S(=O)(=O)c1cccc3ccccc13)nn2C,,ClC(Cl)Cl,,C1CCOC1,Cl,val
US20040006099A1,CCOC(=O)C1(CCOS(C)(=O)=O)CCN(C(=O)OC(C)(C)C)CC1.[I-]>>CCOC(=O)C1(CCI)CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,O,,val
US20020137961A1,CC(C)(C)[Si](C)(C)Oc1ccc([C@@H]2CC[C@@H](O)CC2)c(O[Si](C)(C)C(C)(C)C)c1.O=C=NCc1ccccc1>>O=C(NCc1ccccc1)O[C@@H]1CC[C@@H](c2ccc(O)cc2O)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20140038952A1,CC(C)(C)OC(=O)Nc1ncc(-c2nc(N3CCOCC3)c3ncc(-c4cccc(NC(=O)CCl)c4)cc3n2)cn1.OC1CCNCC1>>CC(C)(C)OC(=O)Nc1ncc(-c2nc(N3CCOCC3)c3ncc(-c4cccc(NC(=O)CN5CCC(O)CC5)c4)cc3n2)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150018422A1,CC(C)(C)Cc1cc(OCc2ccccc2)cnc1OS(=O)(=O)C(F)(F)F.COc1ccc(F)c(B(O)O)c1>>COc1ccc(F)c(-c2ncc(OCc3ccccc3)cc2CC(C)(C)C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O,O=C([O-])[O-].[Na+].[Na+],val
US05134144,CC(C)Br.Cc1ccc([N+](=O)[O-])cc1O>>Cc1ccc([N+](=O)[O-])cc1OC(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06211234B1,O=C(OCc1ccccc1)c1ccc(C#Cc2ccccc2)cc1OCc1ccccc1>>O=C(O)c1ccc(C#Cc2ccccc2)cc1OCc1ccccc1,,C1COCCO1,,[Na+].[OH-],,val
US20120245137A1,CC(C)(C)OC(=O)NCC1CCC(O)CC1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)NCC1CCC(OS(C)(=O)=O)CC1,,ClCCl,,,,val
US20020099212A1,Cc1nc2nc(Br)ccc2[nH]1.N#C[Cu]>>Cc1nc2ccc(C#N)[nH]c-2n1,,CN(C)C=O,,,,val
US05183804,CC(C)(C)OC(=O)NCC(=O)O.N[C@H](C(=O)O)C(Cc1ccccc1)C(=O)O>>CC(C)(C)OC(=O)NCC(=O)N[C@H](C(=O)O)C(Cc1ccccc1)C(=O)O,,C1CCOC1,O,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20090275624A1,COC1=CC(=O)c2sc(C(=O)Nc3ccc(OC)cc3)nc2C1=O.Cc1nc2c(s1)C(=O)C=C(NCCCN(C)CCCN)C2=O>>COc1ccc(NC(=O)c2nc3c(s2)C(=O)C=C(NCCCN(C)CCCNC2=CC(=O)c4sc(C)nc4C2=O)C3=O)cc1,,CCO,,,,val
US20080319005A1,CC(C)N1CCNCC1.O=[N+]([O-])c1ccc(CCl)cc1>>CC(C)N1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060247210A1,Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)Cl)cc2s1.NCCN1CCOCC1>>Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)NCCN3CCOCC3)cc2s1,,CO,,CN1CCOCC1,,val
US20090270364A1,COC(=O)C1CCC2CCCCC2C1=O.N=C(N)N>>Nc1nc(O)c2c(n1)C1CCCCC1CC2,,CN(C)C=O,,O=C(O)O,,val
US05886210,CCO.O=C(Cl)c1cc(F)c(Cl)cc1Cl>>CCOC(=O)c1cc(F)c(Cl)cc1Cl,,CCOCC,CCOCC,,,val
US20100137313A1,Cc1cc(C(F)(F)F)n[nH]1.Clc1ncc(Br)c(Cl)n1>>Cc1cc(C(F)(F)F)nn1-c1nc(Cl)ncc1Br,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20020035266A1,COC(=O)C(CC1CCCC1)c1ccc(-n2nnnc2C)c(C(F)(F)F)c1>>Cc1nnnn1-c1ccc(C(CC2CCCC2)C(=O)O)cc1C(F)(F)F,,CCO,,[Na+].[OH-],,val
US20150376160A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4sc(Cl)cc4NC(=O)O[C@H](C)c4ccc(Cl)cc4)cc3)cc2)CC1>>C[C@@H](OC(=O)Nc1cc(Cl)sc1-c1ccc(-c2ccc(C3(C(=O)O)CC3)cc2)cc1)c1ccc(Cl)cc1,,CC(C)O,,Cl,[Na+].[OH-],val
US06350749B1,ClP(Cl)Cl.O=C1CC(=O)CC(c2ccccc2Cl)C1>>O=C1C=C(Cl)CC(c2ccccc2Cl)C1,,ClC(Cl)Cl,,,,val
US20100310466A1,COC(=O)c1scc(Br)c1O.O=c1cc(N2CCOCC2)oc2c(B(O)O)csc12>>COC(=O)c1scc(-c2csc3c(=O)cc(N4CCOCC4)oc23)c1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120283273A1,CC(C)(C)OC(=O)c1c(C(F)(F)F)[nH]c2ncc(C#N)cc12>>N#Cc1cnc2[nH]c(C(F)(F)F)c(C(=O)O)c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040053908A1,COc1cc2c(Oc3ccc([N+](=O)[O-])cc3)ccnc2cc1C#N>>COc1cc2c(Oc3ccc(N)cc3)ccnc2cc1C#N,[Fe],,,,,val
US20080255122A1,CC(C)(C)N1C(=O)C(Cl)=C(c2ccccc2)S1(=O)=O.Nc1ccc(N2CCCCCC2)cc1>>CC(C)(C)N1C(=O)C(Nc2ccc(N3CCCCCC3)cc2)=C(c2ccccc2)S1(=O)=O,,CC#N,,,,val
US20040116694A1,COc1ccc(F)cc1C(C)(C)CC(O)(CNc1ccnc2ccccc12)C(F)(F)F>>CC(C)(CC(O)(CNc1ccnc2ccccc12)C(F)(F)F)c1cc(F)ccc1O,,CO,ClCCl,BrB(Br)Br,,val
US20150111877A1,COC(=O)c1cnc(O[C@@H](C)C(=O)OC)c([N+](=O)[O-])c1>>COC(=O)c1cnc2c(c1)NC(=O)[C@H](C)O2,[Fe],CC(=O)O,,,,val
US05294734,CCOC(=O)C(N)C=C(CCOC)CP(=O)(O)O>>COCCC(=CC(N)C(=O)O)CP(=O)(O)O,,O,,,,val
US04584290,O=CNC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(C=C(Br)Br)CS(=O)[C@H]12>>C#CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC=O)[C@H]2S(=O)C1,,CCOC(C)=O,,Cl,[Li]CCCC,val
US05145970,Cc1cc(S)cc(C(C)(C)C)c1N.O=C1C=CC(=O)N1c1ccccc1>>Cc1cc(SC2CC(=O)N(c3ccccc3)C2=O)cc(C(C)(C)C)c1N,,Cc1ccccc1,,CCN(CC)CC,,val
US20090162283A1,C[Mg]Br.O=Cc1ccc(-c2cn3cc(I)ccc3n2)cc1>>CC(O)c1ccc(-c2cn3cc(I)ccc3n2)cc1,,C1CCOC1,,O,[Cl-].[NH4+],val
US20040229858A1,COC(=O)c1ccc(O)c(Cl)c1.C[C@@H](CO)NC(=O)OC(C)(C)C>>COC(=O)c1ccc(OC[C@H](C)N)c(Cl)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04009197,Br[Mg]c1ccccc1.O=C1CCc2ccccc2C1>>c1ccc(-c2ccc3ccccc3c2)cc1,,CCOCC,,,,val
US20090131467A1,NN.O=C(Cc1ccccc1Cl)c1c(O)c2cccnc2n(-c2cccc(C(F)(F)F)c2)c1=O>>O=c1c2c(Cc3ccccc3Cl)n[nH]c2c2cccnc2n1-c1cccc(C(F)(F)F)c1,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US04897444,C=CCBr.O=C(N[C@@H](Cc1ccccc1)C(=O)Nc1ccc2ncccc2c1)OCc1ccccc1>>C=CCN1CC=Cc2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)OCc3ccccc3)ccc21.[Br-],,CCOCC,,CN(C)C=O,,val
US20100144825A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)CCNC>>CCOC(=O)CCN(C)C(=O)OC(C)(C)C,,ClCCl,,O,,val
US20040072859A1,Cc1nc2c(N)nc3ccccc3c2n1CCOCCN.O=C=Nc1ccccc1>>Cc1nc2c(N)nc3ccccc3c2n1CCOCCNC(=O)Nc1ccccc1,,CN1CCCC1=O,,CCN(CC)CC,,val
US20150266857A1,CC(C)(C)OC(=O)n1cc(-c2ccc3c(c2)C(=O)NS3(=O)=O)c2ccc(F)cc21.CI>>CN1C(=O)c2cc(-c3cn(C(=O)OC(C)(C)C)c4cc(F)ccc34)ccc2S1(=O)=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090324581A1,CC(C)(C)OC(=O)n1ccc2cc(-c3ccc(OCc4ccccc4)cc3)ccc21>>CC(C)(C)OC(=O)N1CCc2cc(-c3ccc(O)cc3)ccc21,[Pd],C1CCOC1,CCO,,,val
US20150038485A1,Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1.OC[C@H]1CCNC1>>OC[C@H]1CCN(c2ccc3ncc(-c4cc5ccccc5o4)n3n2)C1,,CCCCO,,Cl,O=C([O-])O.[Na+],val
US20090048301A1,CSC(=N)Nc1ccc2c(c1)OCCO2.NNC(=O)c1cccnc1OCc1ccc2c(c1)OCO2>>c1cnc(OCc2ccc3c(c2)OCO3)c(-c2nnc(Nc3ccc4c(c3)OCCO4)[nH]2)c1,,c1ccncc1,,CCN(CC)CC,O,val
US04900749,CC(C)=CCCC(C)=CCCC(C)=CCN.O=C(O)c1cccnc1>>CC(C)=CCCC(C)=CCCC(C)=CCNC(=O)c1cccnc1,,ClCCl,,CCN(CC)CC,C[n+]1ccccc1Cl.[I-],val
US20090264445A1,CC(C)(O)Cn1ccc(NC(=O)[C@H](CC2CCCCC2)N2CC(Oc3ccccc3Cl)=CC2=O)n1.CCOC(=O)[C@H](N)CC(C)CC>>CCOC(=O)[C@@H](CC(C)CC)N1CC(Oc2ccccc2Cl)=CC1=O,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US06008230,CC(C)(C)OC(=O)Nc1cnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1-n1ccnc1>>Nc1cnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1-n1ccnc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140194418A1,COC(=O)c1ccc(Nc2nc(SC)nc(Cl)c2C(N)=O)c(OC)c1.[NH4+]>>COC(=O)c1ccc(Nc2nc(SC)nc(N)c2C(N)=O)c(OC)c1,,CS(C)=O,,O,,val
US20150141413A1,CCOC(=O)C(C)(C)SC[C@](C)(NCc1ccc(OC)cc1OC)c1cc(Br)ccc1F>>COc1ccc(CN[C@@](C)(CSC(C)(C)C(=O)O)c2cc(Br)ccc2F)c(OC)c1,,CCO,,Cl,[Na+].[OH-],val
US20050107388A1,COc1cc(C=O)c(O)c([N+](=O)[O-])c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1cc(C=O)c(OS(=O)(=O)C(F)(F)F)c([N+](=O)[O-])c1,,ClCCl,,CCN(CC)CC,,val
US20110118236A1,CCOC(=O)CBr.COc1ccc(Cl)cc1NC(=O)Cn1nc(C(F)(F)F)c2c1CNCC2>>CCOC(=O)CN1CCc2c(C(F)(F)F)nn(CC(=O)Nc3cc(Cl)ccc3OC)c2C1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04226773,CC(=O)N1CCN=C1Nc1ccnn1-c1cccc(C(F)(F)F)c1.Cl>>Cl.FC(F)(F)c1cccc(-n2nccc2NC2=NCCN2)c1,,CO,,,,val
US20050209274A1,N#Cc1ccc(F)c(F)c1.NCCCN1CCCC1>>N#Cc1ccc(NCCCN2CCCC2)c(F)c1,,CO,,,,val
US20110124634A1,C=C(C)C.CC(C)CC(CN)C(=O)O>>CC(C)CC(CN)C(=O)OC(C)(C)C,,C1COCCO1,CCOCC,O=S(=O)(O)O,[Na+].[OH-],val
US20080255086A1,NC(=O)c1c(NC(=O)CBr)sc2c1CCCC2.OCCc1c[nH]nc1C(F)(F)F>>NC(=O)c1c(NC(=O)Cn2cc(CCO)c(C(F)(F)F)n2)sc2c1CCCC2,,CN(C)C=O,CO,O=C([O-])[O-].[K+].[K+],,val
US20130137680A1,CCOC(=O)c1ccc2cc(C(=O)OCC)n(CC(C)(C)CN)c2n1>>CC1(C)CNC(=O)c2cc3ccc(C(=O)O)nc3n2C1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US06172108B2,N[C@@H](Cc1ccccc1)C(=O)O.O=S(=O)(Cl)c1ccc2ccccc2c1>>O=C(O)C(Cc1ccccc1)NS(=O)(=O)c1ccc2ccccc2c1,,ClCCl,O,[Na+].[OH-],,val
US20080214448A1,COC(=O)CCCCc1coc(-c2ccccc2OC)n1>>COC(=O)CCCCc1coc(-c2ccccc2O)n1,,ClCCl,,BrB(Br)Br,,val
US20070249589A1,COc1ccc(CCl)cc1.Cc1ccc(O)c(CO)n1>>COc1ccc(COc2ccc(C)nc2CO)cc1,,CN(C)C=O,ClCCl,[H-].[Na+],,val
US04179505,COC(=O)Nc1nc2cc(CN3CCN(C(c4ccccc4)c4ccccc4)CC3)ccc2n1C>>Cn1c(N)nc2cc(CN3CCN(C(c4ccccc4)c4ccccc4)CC3)ccc21,,O,,Cl,[Na+].[OH-],val
US20160222014A1,CC(C)(C)OC(=O)NC1CCCNC1.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)NC1CCCN(c2ccc([N+](=O)[O-])cc2)C1,,CC#N,O,CCN(C(C)C)C(C)C,,val
US20050143421A1,CC(=O)NC[C@H]1CN(c2ccc(N3CCC(O)(CO)CC3)c(F)c2)C(=O)O1.CS(=O)(=O)Cl>>CC(=O)NC[C@H]1CN(c2ccc(N3CCC(O)(COS(C)(=O)=O)CC3)c(F)c2)C(=O)O1,,ClCCl,,CCN(CC)CC,,val
US20080090889A1,CC(C)=CCn1c(SCCCNC(=O)OC(C)(C)C)nc2ccc(NC(=O)c3ccccc3)cc21.O=C(O)C(F)(F)F>>CC(C)=CCn1c(SCCCN)nc2ccc(NC(=O)c3ccccc3)cc21.O=C(O)C(F)(F)F,,O,,,,val
US20100075968A1,CN1C(=O)N(c2cncn2C)C[C@H]1C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CN1C(=O)N(c2cncn2C)CC1C(=O)O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04564613,C1CCNCC1.C=O.CN1Cc2c(ccc3cc[nH]c23)C(c2ccccc2)C1>>CN1Cc2c(ccc3c2NCC3CN2CCCCC2)C(c2ccccc2)C1,,CC(=O)O,,O,,val
US05688795,CNC.Cl.O=C(O)c1cccnc1O.O=C1CCC(=O)N1I>>CN(C)C(=O)c1cc(I)cnc1Cl,,CN(C)C=O,,CCN(CC)CC,O=S(Cl)Cl,val
US20140057894A1,CCOC(=O)c1ccn2nc(-c3ccc(OC)cc3)cc2n1>>COc1ccc(-c2cc3nc(C(=O)O)ccn3n2)cc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20130137709A1,C[Si](C)(C)CCOCCl.Clc1nc(Cl)c2c(Cl)c[nH]c2n1>>C[Si](C)(C)CCOCn1cc(Cl)c2c(Cl)nc(Cl)nc21,,CN(C)C=O,,[H][H],[H-].[Na+],val
US04070539,CCC1Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1=O.CO>>CCC1Cc2cc(OCC(=O)OC)c(Cl)c(Cl)c2C1=O,,CO,,CCOCC,FB(F)F,val
US20040014735A1,CN.O=S(=O)([O-])CCCCCCC(F)(F)C(F)(F)C(F)(F)F>>CNCCCCCC(F)(F)C(F)(F)C(F)(F)F,,C1CCOC1,,,,val
US20090143384A1,C1COCCN1.COc1ncc(-c2cc(Cl)nc(-c3cccc(NC(=O)C4CCN(C(=O)OC(C)(C)C)CC4)c3)n2)c(OC)n1>>COc1ncc(-c2cc(N3CCOCC3)nc(-c3cccc(NC(=O)C4CCNCC4)c3)n2)c(OC)n1,,CC#N,,,,val
US20010018525A1,CCCCCCCCCCCCN.CCOC(=O)c1cc(-c2cccc(C(F)(F)F)c2)c(OCCO)c(-c2cccc(C(F)(F)F)c2)c1>>CCCCCCCCCCCCNC(=O)c1cc(-c2cccc(C(F)(F)F)c2)c(OCCO)c(-c2cccc(C(F)(F)F)c2)c1,,C1CCOC1,,Cl,[Li]CCCC,val
US04533744,C=CCOC(=O)C(=C)C.Cl[SiH](Cl)Cl>>C=C(C)C(=O)OCCC[Si](Cl)(Cl)Cl,,CCCCCC,,,,val
US20130040978A1,CC1(C)CCOc2ccc(Br)cc21.CN(C)C=O>>CC1(C)CCOc2ccc(C=O)cc21,,CCOC(C)=O,,C1CCOC1,[Li]CCCC,val
US06277861B1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1NCCc2c(N)cccc21>>CC1c2cccc(N)c2CCN1C(=O)OC(C)(C)C,,C1COCCO1,,O,[Na+].[OH-],val
US20160039811A1,COc1ccn(C(C2CC2)C2CC2)c(=O)c1C#N.O=C1CCC(=O)N1Br>>COc1c(Br)cn(C(C2CC2)C2CC2)c(=O)c1C#N,,CN(C)C=O,,,,val
US20120110701A1,Clc1ccc(/C=N/n2cc(-c3cccnc3)nc2Cl)cc1>>Nn1cc(-c2cccnc2)nc1Cl,,COCCO,,NN,O,val
US20150252032A1,N=C(NOC(=O)[C@@H]1CCCN1C(=O)c1ccoc1)c1ccccc1>>O=C(c1ccoc1)N1CCC[C@H]1c1nc(-c2ccccc2)no1,,C1COCCO1,,,,val
US20080167287A1,COC(=O)Cl.NCc1ccc(Br)cc1F>>COC(=O)NCc1ccc(Br)cc1F,,ClCCl,,CCN(CC)CC,,val
US20120202785A1,C[C@H](N)c1nc2c(Cl)cccc2n1-c1ccccc1.Clc1ncnc2[nH]cnc12>>C[C@H](Nc1ncnc2[nH]cnc12)c1nc2c(Cl)cccc2n1-c1ccccc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US04678792,Cc1cccc2c1CCN=C2.ClCc1ccccc1Cl>>Cc1cccc2c1CC[N+](Cc1ccccc1Cl)=C2.[Cl-],,C1COCCO1,,,,val
US20120107416A1,NNC(=O)c1cccc(OC(F)(F)F)c1.O=Cc1cc(Cl)cc(Cl)c1O>>O=C(NN=Cc1cc(Cl)cc(Cl)c1O)c1cccc(OC(F)(F)F)c1,,CCO,,,,val
US20130324579A1,CI.COc1ccc2[nH]cc(CCBr)c2c1>>COc1ccc2c(c1)c(CCBr)cn2C,,C1CCOC1,,[H-].[Na+],,val
US06172085B2,Cc1c(C)c2c(c(C)c1N)C[C@](C)(CN1CCC(NC(c3ccccc3)c3ccccc3)CC1)O2.O=S(=O)(O)O>>Cc1c(C)c2c(c(C)c1N)C[C@](C)(CN1CCC(NC(c3ccccc3)c3ccccc3)CC1)O2.O=S(=O)(O)O,,CCOC(C)=O,CO,,,val
US08785639B2,COc1ccc([Mg]Br)cc1.Cc1ccc(S(=O)(=O)n2ccc3nc(C#N)cnc32)cc1>>COc1ccc(C(=N)c2cnc3c(ccn3S(=O)(=O)c3ccc(C)cc3)n2)cc1,,C1CCOC1,,,,val
US20050065143A1,CC(C)(C)C(O)CNC(=O)c1ccc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)nn1.CI>>COC(CNC(=O)c1ccc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)nn1)C(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20060183739A1,COC1(OC)C[NH2+][C@@H](C(=O)Nc2ccc(-n3ccccc3=O)cc2)C1.O=C=Nc1ccc(Cl)cc1>>COC1(OC)C[C@H](C(=O)Nc2ccc(-n3ccccc3=O)cc2)N(C(=O)Nc2ccc(Cl)cc2)C1,,ClCCl,,CCN(CC)CC,,val
US20100121022A1,C#CCBr.Oc1cccc(O)c1>>C#CCOc1cccc(O)c1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20010023257A1,ON=C1CC2CC1C1C=CCC21>>NC1CC2CC1C1CCCC21,[Ni],CO,O,,,val
US20060089371A1,CN(C)CCOc1cccc(C[C@H](Nc2cc(-c3ccc(OCc4ccccc4)cc3)ncn2)C(=O)[O-])c1>>CN(C)CCOc1cccc(C[C@H](Nc2cc(-c3ccc(OCc4ccccc4)cc3)ncn2)C(=O)O)c1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20100197680A1,COC(=O)c1ccc(CCC(/C=C/c2ccccc2O)Cc2ccc(C(=O)OC)cc2)cc1.ClCCCCBr>>COC(=O)c1ccc(CCC(/C=C/c2ccccc2OCCCCCl)Cc2ccc(C(=O)OC)cc2)cc1,,Cc1ccccc1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05449686,COCOC1=C(C(N)=O)CC(C#N)(c2ccc(OC)c(OCC3CC3)c2)CC1>>COc1ccc(C2(C#N)CCC(=O)C(C(N)=O)C2)cc1OCC1CC1,CC(=O)O,,,,,val
US20140309225A1,CC(C)(C)OC(=O)NC1CN(C(=O)OCc2ccccc2)CCC1O.O=C1NC(=O)c2ccccc21>>CC(C)(C)OC(=O)NC1CN(C(=O)OCc2ccccc2)CCC1N1C(=O)c2ccccc2C1=O,,C1CCOC1,O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090088425A1,COC(=O)c1ccc(C(C)C(O)(c2ccnc(Cl)c2)C(F)(F)F)c(Cl)c1>>CC(c1ccc(C(=O)O)cc1Cl)C(O)(c1ccnc(Cl)c1)C(F)(F)F,,C1CCOC1,CO,[Li+].[OH-],,val
US20070032478A1,CN(C)CCc1ccc(N)cc1.Cc1cc(C(=O)Nc2cccc(C(=O)c3ccc4c(c3)NC(=O)C4=CO)c2)n(C)n1>>Cc1cc(C(=O)Nc2cccc(C(=O)c3ccc4c(c3)NC(=O)C4=CNc3ccc(CCN(C)C)cc3)c2)n(C)n1,,C1CCOC1,,,,val
US20110172202A1,CC(=O)Cl.CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@@H]4N)no2)cc1C#N>>CC(=O)N[C@H]1CCc2c(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)cccc21,,ClCCl,,Cl,,val
US20110065702A1,Cc1ccc2c(c1)C(=O)C(=O)N2.Nc1ccc2cn[nH]c2c1>>Cc1ccc2c(c1)C(=Nc1ccc3cn[nH]c3c1)C(=O)N2,CC(=O)O,CCO,,,,val
US03966938,CC(C)(C)C(=O)OC(=O)C(C)(C)C.COc1cc2c(cc1OC)C1CN(C)CCC1N=C2c1ccc(N)cc1>>COc1cc2c(cc1OC)[C@@H]1CN(C)CC[C@@H]1N=C2c1ccc(NC(=O)C(C)(C)C)cc1,,O,,c1ccncc1,,val
US20110172245A1,C#CC(C)(C)Cl.COC(=O)c1cccc(O)c1>>C#CC(C)(C)Oc1cccc(C(=O)OC)c1,Cl[Cu]Cl,CC#N,,C1CCC2=NCCCN2CC1,O,val
US20090281318A1,O=S(=O)(c1ccccc1)N1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1>>Clc1ccc(C(c2ccccc2)N2CCNCC2)cc1,,CC(=O)O,,Br,O,val
US20060160821A1,CN(C)N=C1C=CC(N)=CC1.CN1CCN=C1c1ccc(NC(=O)C(NC(=O)Nc2ccc(Cl)cc2)c2ccccc2Br)cc1>>CN(C)N=C1C=CC(NC(=O)C(NC(=O)Nc2ccc(Cl)cc2)c2ccccc2Br)=CC1,,CN(C)C=O,O,ClCCCl,,val
US05086065,CC(C)(C)OC(=O)CCc1cc(N)ccc1O.O=C(O)C(F)(F)F>>CC(C)(C)OC(=O)CCc1cc(NC(=O)C(F)(F)F)ccc1O,,C1CCOC1,CCN(CC)CC,Cl,,val
US20040058425A1,CC(C)c1ccc(CO)cc1.COC(=O)Cc1ccc(O)c(Cl)c1>>COC(=O)Cc1ccc(OCc2ccc(C(C)C)cc2)c(Cl)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110190280A1,CCNC(N)=S.COc1ccnc(C(=O)Cc2ccnc(Cl)n2)c1>>CCNc1nc(-c2cc(OC)ccn2)c(-c2ccnc(Cl)n2)s1,,ClCCl,,O=C1CCC(=O)N1Br,,val
US20060287522A1,O=C(Cl)C(Cl)(Cl)Cl.O=C(c1ccc(-c2ccccc2)cc1)N1Cc2cccn2Cc2ccccc21>>O=C(c1ccc(-c2ccccc2)cc1)N1Cc2ccc(C(=O)C(Cl)(Cl)Cl)n2Cc2ccccc21,,C1COCCO1,,O,,val
US20090054435A1,Brc1ccc(OCc2ccccc2)cc1.COCOc1cc(OC)ccc1C(=O)N(C)OC>>COCOc1cc(OC)ccc1C(=O)c1ccc(OCc2ccccc2)cc1,,C1CCOC1,,O,[Li]CCCC,val
US20140135369A1,CI.COC(=O)C1CCCC2(C1)CN(CC(C)(C)C)C(=O)O2>>COC(=O)C1(C)CCCC2(CN(CC(C)(C)C)C(=O)O2)C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20040092502A1,CCOC(=O)c1cc2cccc3c2n(c1=O)CCC3.COCN(Cc1ccccc1)C[Si](C)(C)C>>CCOC(=O)[C@@]12CN(Cc3ccccc3)C[C@@H]1c1cccc3c1N(CCC3)C2=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060257987A1,CCCC(CCOS(C)(=O)=O)Oc1ccc2c(-c3ccccc3)coc2c1.CCOC(=O)C(C)(C)Oc1ccc(O)cc1>>CCCC(CCOc1ccc(OC(C)(C)C(=O)OCC)cc1)Oc1ccc2c(-c3ccccc3)coc2c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04620865,CCOC(=O)c1cnn(-c2ccccc2)c1Br>>O=C(O)c1cnn(-c2ccccc2)c1Br,,CCO,,Cl,[K+].[OH-],val
US20020072533A1,CCCC(C)Br.O=C1CC(CI)CN1Cc1ccccc1>>CCCC(C)CC1CC(=O)N(Cc2ccccc2)C1,,C1CCOC1,,II,[Mg],val
US20080153828A1,Cc1cc2ncn(C)c2cc1C.O=C1CCC(=O)N1I>>Cc1cc2nc(I)n(C)c2cc1C,,C1CCOC1,,[Li]C(C)(C)C,,val
US20060100460A1,CC(C)(C)OC(=O)COc1ccc2c(c1)CCCC2(C)C>>CC1(C)CCCc2cc(O)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050090541A1,CCOC(=O)CCC(=O)c1cc[nH]c1.CN(C)C=O>>CCOC(=O)CCC(=O)c1c[nH]c(C=O)c1,,ClCCCl,,O=P(Cl)(Cl)Cl,,val
US04537969,O=CC1CC(CCn2ccnc2)CCCN1>>c1cn(CCC2CCCNCC2)cn1,,C1COCCO1,Cl,,,val
US20070093501A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC(C(=O)O)c1cccs1>>CC(C)(C)OC(=O)NC(C(=O)O)c1cccs1,,C1CCOC1,O,CCN(CC)CC,,val
US20160046617A1,COc1ccc(Cl)cc1-c1cnn2c1NCCC2>>Oc1ccc(Cl)cc1-c1cnn2c1NCCC2,,ClCCl,O,BrB(Br)Br,,val
US20080039452A1,COC(=O)c1ccc(CBr)c(OC)c1.O>>COC(=O)c1ccc(C=O)c(OC)c1,,CS(C)=O,,O=C([O-])O.[Na+],,val
US20070259846A1,Clc1ccc(N2CCNCC2)cc1.NCCCc1nc(Cl)nc2c1S(=O)(=O)CC2>>NCCCc1nc(N2CCN(c3ccc(Cl)cc3)CC2)nc2c1S(=O)(=O)CC2,,C1COCCO1,,,,val
US05484928,Nc1nc(/C(=N/OCC(=O)OC(c2ccccc2)c2ccccc2)C(=O)O)cs1.c1ccc2sc(SSc3nc4ccccc4s3)nc2c1>>Nc1nc(/C(=N/OCC(=O)OC(c2ccccc2)c2ccccc2)C(=O)Sc2nc3ccccc3s2)cs1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20110034464A1,C1COCCN1.CC(=O)NCc1cc(F)ccc1S(=O)(=O)Cl>>Cl.NCc1cc(F)ccc1S(=O)(=O)N1CCOCC1,,C1CCOC1,CO,CCN(CC)CC,,val
US05387695,COc1ccc2c(c1)C(C)C(=O)N2C.N#CCCl>>COc1ccc2c(c1)C(C)(CC#N)C(=O)N2C,,Cc1ccccc1,,[Na+].[OH-],,val
US20120046308A1,CCCCc1nc(C)n(-c2ccccn2)c(=O)c1Cc1cc(CCC)c(OC(C(=O)O)c2ccccc2)c(CCC)c1.CS(N)(=O)=O>>CCCCc1nc(C)n(-c2ccccn2)c(=O)c1Cc1cc(CCC)c(OC(C(=O)NS(C)(=O)=O)c2ccccc2)c(CCC)c1,,CN(C)C=O,,C1CCC2=NCCCN2CC1,Cl,val
US20160120841A1,CC(=O)c1ccccc1O.CCOC(=O)C1CC(C=O)C1>>CCOC(=O)C1CC(C2CC(=O)c3ccccc3O2)C1,,CCO,,C1CCNC1,,val
US20080132524A1,Cc1cccc(C2=NCCN2)c1N.O=C1CCC(=O)N1Br>>Cc1cc(Br)cc(C2=NCCN2)c1N,,CCOC(C)=O,CN(C)C=O,,,val
US20130150360A1,CC(C)N1CCN(c2ccc(N)nc2)CC1.Clc1cc(Br)c2nccn2n1>>CC(C)N1CCN(c2ccc(Nc3cc(Cl)nn4ccnc34)nc2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20050065118A1,NC(=S)Nc1cccc(Br)c1.O=C(CBr)c1ccc(Cl)c(Cl)c1>>Clc1ccc(-c2csc(Nc3cccc(Br)c3)n2)cc1Cl,,C1COCCO1,,c1ccncc1,,val
US20030225283A1,CS(=O)(=O)c1ccc([C@@H](CC2CCC(OC=O)C2)C(=O)Nc2cnccn2)cc1Cl>>CS(=O)(=O)c1ccc([C@@H](CC2CCC(O)C2)C(=O)Nc2cnccn2)cc1Cl,,CO,,N,,val
US20130053364A1,CCOC(=O)c1c(CS(=O)(=O)c2ccccc2)ccc(Br)c1OC.OB(O)c1ccoc1>>CCOC(=O)c1c(CS(=O)(=O)c2ccccc2)ccc(-c2ccoc2)c1OC,,C1CCOC1,O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],val
US20160158207A1,Cc1ccc([N+](=O)[O-])cc1-c1cnn(C)c1>>Cc1ccc(N)cc1-c1cnn(C)c1,[Fe],CO,,,,val
US20120225888A1,Cc1ccc(-c2c(CO)c(C)nc3cc(-c4ccccc4)nn23)cc1>>Cc1ccc(-c2c(C=O)c(C)nc3cc(-c4ccccc4)nn23)cc1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20160159767A1,CI.O=C1OC[C@@H](O)[C@H]1O>>CO[C@H]1C(=O)OC[C@H]1O,O=[Ag-],ClC(Cl)Cl,,,,val
US20090239854A1,C=Cc1cnc(C)cn1.CC(C)c1ccc2[nH]c3c(c2c1)CN(C)CC3>>Cc1cnc(CCn2c3c(c4cc(C(C)C)ccc42)CN(C)CC3)cn1,,CN1CCCC1=O,O,[K+].[OH-],,val
US05162326,BrCc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.O=c1cc(Cl)[nH]c(=O)n1Cc1ccccc1>>O=c1cc(Cl)n(Cc2ccc(-c3ccccc3-c3nnnn3C(c3ccccc3)(c3ccccc3)c3ccccc3)cc2)c(=O)n1Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160009744A1,Cc1sc(C(=O)c2cncnc2N[C@H]2C[C@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H](COS(N)(=O)=O)C2)cc1Sc1cccc(Cl)c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CC(C)[Si](O[C@H]1C[C@H](Nc2ncncc2C(=O)c2cc(S(=O)c3cccc(Cl)c3)c(Cl)s2)C[C@@H]1COS(N)(=O)=O)(C(C)C)C(C)C,,O=C([O-])O,[Na+],,,val
US20100273770A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)CC1NCCOc2c(Br)cccc21>>CCOC(=O)CC1c2cccc(Br)c2OCCN1C(=O)OC(C)(C)C,,C1CCOC1,,CCN(CC)CC,,val
US20130338196A1,COC(=O)C1Cc2ccc(OC)cc2C1=O>>COC(=O)C1Cc2ccc(OC)cc2C1,[Pd],CC(=O)O,,[O-][Cl+3]([O-])([O-])O,,val
US20050197340A1,CCOc1ccc(F)cc1B(O)O.OC(CI)CNc1nc(Oc2ccc(F)cc2F)nc2[nH]ncc12>>CCOc1ccc(F)cc1-c1n[nH]c2nc(Oc3ccc(F)cc3F)nc(NC[C@@H](C)O)c12,,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20040106655A1,C1CNCCN1.Clc1nc(-c2ccccc2)nc2ccccc12>>c1ccc(-c2nc(N3CCNCC3)c3ccccc3n2)cc1,,CN(C)C=O,,,,val
US20120316147A1,COC(=O)c1ccc(C)c(S(=O)(=O)N2CCCCC2)n1>>Cc1ccc(C(=O)O)nc1S(=O)(=O)N1CCCCC1,,C1COCCO1,O,[Li+].[OH-],,val
US20100324103A1,CC(=O)OCC#CCC(=O)OC(C)C.CNCc1ccc(Cl)nc1>>CC(=O)OCC(=CCC(=O)OC(C)C)NCc1ccc(Cl)nc1,,C1CCOC1,,,,val
US04921530,CCN(CC)CC.COC(=O)c1c(C(F)F)nc(C(F)(F)F)c(C(=O)OC)c1OC(C)C.Cl.NN1CCCC1>>CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)Cl)c(C(=O)OC)c1NN1CCCC1,,CN(C)C=O,,O,,val
US20040157885A1,CCOC(=O)COc1cc(C2CCCN(C(=O)c3sc(-c4ccc(C(F)(F)F)cc4)nc3C)C2)ccc1C>>Cc1ccc([C@@H]2CCCN(C(=O)c3sc(-c4ccc(C(F)(F)F)cc4)nc3C)C2)cc1OCC(=O)O,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US04179506,O=C(OO)c1cccc(Cl)c1.c1ccc2c(c1)Oc1ccncc1O2>>[O-][n+]1ccc2c(c1)Oc1ccccc1O2,,ClCCl,,,,val
US20110003845A1,CC1(C)OC[C@@H](COc2ccc(-c3c(C#N)c(N)nc(SCc4coc(-c5ccc(Cl)cc5)n4)c3C#N)cc2)O1>>N#Cc1c(N)nc(SCc2coc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1ccc(OC[C@@H](O)CO)cc1,,CC(=O)O,,O,,val
US20090111983A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1(C(=O)OCc2ccccc2)CCCCC1.O=C(c1ccccc1)N1CCNCC1>>O=C(NC1(C(=O)OCc2ccccc2)CCCCC1)N1CCN(C(=O)c2ccccc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20070155805A1,CCCCC(CCBr)c1sc2cc(C(F)(F)F)ccc2c1C.CCOC(=O)COc1ccc(O)cc1C>>CCCCC(CCOc1ccc(OCC(=O)OCC)c(C)c1)c1sc2cc(C(F)(F)F)ccc2c1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080242665A1,COc1ccnc(N)n1.O=C1CCC(=O)N1I>>COc1nc(N)ncc1I,,CC(=O)O,,,,val
US20060089359A1,O=c1c2ccccc2c(Br)nn1-c1ccc([N+](=O)[O-])cc1>>Nc1ccc(-n2nc(Br)c3ccccc3c2=O)cc1,O=[Pt]=O,CCOC(C)=O,,,,val
US06005000,C1CCOC1.CC1(c2ccccc2)OC(=O)C(O)=C1O.CCC[Mg]Br.CCOC(=O)C(=O)c1ccc(-c2ccccc2)cc1>>CCCC1(c2ccc(-c3ccccc3)cc2)OC(=O)C(OCc2ccccc2)=C1O,,C1CCOC1,,ClC(Cl)Cl,,val
US20060199817A1,Clc1nncc2cc(Br)ccc12.NC(=O)C1CCNCC1>>NC(=O)C1CCN(c2nncc3cc(Br)ccc23)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04789683,CCOc1ccc(Br)c(OCC)c1C(=O)NCC1CCCN1CC>>CCOc1ccc(Br)c(O)c1C(=O)NCC1CCCN1CC,,ClCCl,,BrB(Br)Br,,val
US04520193,CC(=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)OC(C)(C)C)C2SC1)OS(C)(=O)=O>>CC(=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(N)C2SC1)OS(C)(=O)=O,,CC#N,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04647572,C#CC(I)OS(=O)(=O)c1ccc([N+](=O)[O-])cc1.COc1ccc(-c2nnn[nH]2)cc1>>COc1ccc(-c2nnn(CC#CI)n2)cc1,,CN(C)C=O,,[Na+].[OH-],,val
US20150344425A1,CC(C)(C)OC(=O)N[C@H](CO)C1CCC(F)(F)CC1.Cl>>Cl.N[C@H](CO)C1CCC(F)(F)CC1,,C1COCCO1,CCOC(C)=O,,,val
US20080255124A1,N#Cc1ccc(N(CCO)CC(F)(F)F)cc1C(F)(F)F.Oc1ccc(Cl)nc1>>N#Cc1ccc(N(CCOc2ccc(Cl)nc2)CC(F)(F)F)cc1C(F)(F)F,,COCCOC,,,,val
US20100216860A1,COc1cccc2c1c(N)nn2Cc1ccc(C(N)=O)cc1.Cc1ccc(S(=O)(=O)Cl)s1>>COc1cccc2c1c(NS(=O)(=O)c1ccc(C)s1)nn2Cc1ccc(C(N)=O)cc1,,c1ccncc1,,,,val
US20110263612A1,BrCCBr.Oc1cc(Br)ccc1Br>>BrCCOc1cc(Br)ccc1Br,,[Na+],[OH-],,,val
US20160096843A1,CC(=O)C1C(=O)C(c2ccc(Cl)cc2)N(c2cc(C)c(=O)n(C)c2)C1=O.CC(C)NN>>Cc1nn(C(C)C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1,,CCOC(C)=O,CO,,,val
US20130210796A1,C=O.CC(C)(C)OC(=O)N1CCNCC1(C)C.C[Si](C)(C)N=[N+]=[N-].[C-]#[N+]c1ccc(C(F)(F)F)cc1>>CC(C)(C)OC(=O)N1CCN(Cc2nnnn2-c2ccc(C(F)(F)F)cc2)CC1(C)C,,CO,,,,val
US20020061900A1,NC(=O)C1(c2ccc(F)cc2)OC(=O)c2ccccc21.NCCCN>>O=C1c2ccccc2C(O)(c2ccc(F)cc2)C2=NCCCN12,,O,,Cc1ccccc1,,val
US20130172292A1,CON(C)C(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.C[Si](C)(C)CCOCn1cnc2ccccc21>>CC1(C)OB(c2ccc(C(=O)c3nc4ccccc4n3COCC[Si](C)(C)C)cc2)OC1(C)C,,C1CCOC1,,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20140031360A1,CC(C)(C)OC(=O)N1CCC2(CC2)[C@@H](Oc2cncc(-c3nn(C4CCCCO4)c4ccc(-c5ccccc5C#C[Si](C)(C)C)cc34)n2)C1>>C#Cc1ccccc1-c1ccc2c(c1)c(-c1cncc(O[C@H]3CN(C(=O)OC(C)(C)C)CCC34CC4)n1)nn2C1CCCCO1,,CCOC(C)=O,CO,O=C([O-])[O-].[K+].[K+],,val
US05779934,CCCCCCCC=Cc1cnc(-c2ccc(CCCCCC(C)OC3CCCCO3)cc2)nc1>>CCCCCCCC=Cc1cnc(-c2ccc(CCCCCC(C)O)cc2)nc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070032525A1,CC(C)(C)OC(=O)N1CCC(CN)CC1>>CC(C)(C)OC(=O)N1CCCCC1,,C1CCOC1,,,,val
US04526723,CC1(C)CC(=O)CC(=O)C1.CCCCCCCCCCCCCCCC(=O)Cl.CCN(CC)CC.ClCCl>>CCCCCCCCCCCCCCCC(=O)OC1=C(c2ccc(C)cc2)C(=O)CC(C)(C)C1,,ClCCl,,,,val
US20110312953A1,CN.Cc1cc(Cl)cc2c(=O)oc(-c3cnc(Cn4nnc(C(F)(F)F)n4)nc3-c3ccccc3Cl)nc12>>CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cnc(Cn2nnc(C(F)(F)F)n2)nc1-c1ccccc1Cl,,C1CCOC1,,,,val
US20130102585A1,C1CSCCN1.COC(=O)c1ccc2c(Cl)ncnc2c1>>COC(=O)c1ccc2c(N3CCSCC3)ncnc2c1,,CO,,,,val
US04735940,CN(C)C(OC(C)(C)C)OC(C)(C)C.O=C(O)c1cc(-c2ccccc2)c(=O)n2ccc3ccsc3c12>>CC(C)(C)OC(=O)c1cc(-c2ccccc2)c(=O)n2ccc3ccsc3c12,,c1ccccc1,,,,val
US04554283,CON(C)c1nn(-c2ccc(C)c3c2OC(C)(C)C3)c(=O)o1>>CNc1nn(-c2ccc(C)c3c2OC(C)(C)C3)c(=O)o1,,CO,,CCN(C(C)C)C(C)C,,val
US20030181468A1,Cc1sc2ncnc(N)c2c1-c1ccc(Br)cc1.O=C=O>>Cc1sc2ncnc(N)c2c1-c1ccc(C(=O)O)cc1,,C1CCOC1,O,Cl,[Li]CCCC,val
US20130029990A1,Nc1cc(Cl)ccn1.O=[N+]([O-])c1ccc(O)cc1F>>Nc1cc(Oc2ccc([N+](=O)[O-])c(F)c2)ccn1,,CN1CCCC1=O,,Cl,,val
US06008229,CC(=O)Oc1cccn2c(Br)c(C)nc12>>Cc1nc2c(O)cccn2c1Br,,CO,,Cl,[Na+].[OH-],val
US20160083368A1,C#CC(C)(O)c1nccn1CCOS(C)(=O)=O>>C#CC1(C)OCCn2ccnc21,,C1CCOC1,CO,[H-].[Na+],,val
US20100029687A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1cnc(N2CCC(CN[C@H](C)c3cccc4ccccc34)C(c3ccccc3)C2)c(F)c1>>COC(=O)c1cnc(N2CCC(CN(C(=O)OC(C)(C)C)[C@H](C)c3cccc4ccccc34)C(c3ccccc3)C2)c(F)c1,,C1CCOC1,,CCN(CC)CC,,val
US20040082542A1,O=[N+]([O-])c1ccc(F)cc1.Oc1ccc2oc3ccccc3c2c1>>O=[N+]([O-])c1ccc(Oc2ccc3oc4ccccc4c3c2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110124886A1,O=C([O-])CC1CCC2(CC1)OOC1(O2)C2CC3CC(C2)CC1C3>>O=C(O)CC1CCC2(CC1)OOC1(O2)C2CC3CC(C2)CC1C3,,CCO,O,Cl,[Na+].[OH-],val
US20050261358A1,CC(C)CC(NC(=O)Cc1c[nH]c2ccccc12)C(=O)NC1CCC(c2ccccc2)(N(C)C)CC1.Cl>>CC(C)CC(NC(=O)Cc1c[nH]c2ccccc12)C(=O)NC1CCC(c2ccccc2)(N(C)C)CC1.Cl,,CCC(C)=O,,C[Si](C)(C)Cl,,val
US20040242596A1,CCC(Br)c1nc2snc(C)c2c(=O)n1Cc1ccccc1.N>>CCC(N)c1nc2snc(C)c2c(=O)n1Cc1ccccc1,,CO,,,,val
US20130345181A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CS(=O)(=O)n1c(-c2cnn(CC(F)(F)F)c2)cc2cnc(Br)cc21>>CC(C)(C)OC(=O)n1c(-c2cnn(CC(F)(F)F)c2)cc2cnc(Br)cc21,CN(C)c1ccncc1,CO,,CCN(CC)CC,[Na+].[OH-],val
US20120171245A1,Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(S(C)=O)n3)c3cc(Cl)cnc32)cc1.NC1CCCC(C(=O)O)C1O>>Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(NC4CCCC(C(=O)O)C4O)n3)c3cc(Cl)cnc32)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20040002492A1,CC(=O)c1cccc2c1Sc1ccccc1S2.S=C=S>>O=C(CC(=S)S)c1cccc2c1Sc1ccccc1S2,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20030114671A1,C=O.CCC(CC)Oc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1CO>>CCC(CC)Oc1cc(C)nc2c1COCN2c1c(C)cc(C)cc1C,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090062306A1,COCCl.COc1ccc(Br)c(CO)n1>>COCOCc1nc(OC)ccc1Br,,ClCCl,,CCN(C(C)C)C(C)C,CO,val
US05294716,Cc1ccc(B(O)O)cc1.O=[N+]([O-])c1ccc(-n2nnnc2-c2ccccc2Br)cc1>>Cc1ccc(-c2ccccc2-c2nnnn2-c2ccc([N+](=O)[O-])cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],val
US20100204119A1,COc1ccc(CNC(=O)C(C)(C)c2ccc(N3CCOc4ncnc(N)c4C3=O)cc2)cc1>>CC(C)(C(N)=O)c1ccc(N2CCOc3ncnc(N)c3C2=O)cc1,,O=C(O)C(F)(F)F,,,,val
US20020193367A1,C1=COCCC1.COC(=O)c1cccc(-c2nc(CO)sc2C)c1>>COC(=O)c1cccc(C2(COC3CCCCO3)N=CSC2C)c1,,CCOC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20070105904A1,O=[N+]([O-])/C=C/c1ccc(COc2ccccc2)cc1>>O=[N+]([O-])CCc1ccc(COc2ccccc2)cc1,,CS(C)=O,,CC(=O)O,[BH4-].[Na+],val
US20090215767A1,COc1ccc2c(=O)c(-c3ccc(OCC4CO4)cc3)coc2c1.NC1CCCCC1>>COc1ccc2c(=O)c(-c3ccc(OCC(O)CNC4CCCCC4)cc3)coc2c1,,CCO,,,,val
US06846953B1,CCC(=O)Cl.Nc1ccc(Cl)c2ccccc12>>CCC(=O)Nc1ccc(Cl)c2ccccc12,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20130023571A1,O=C(Nc1c(Br)cc(C(F)(C(F)(F)F)C(F)(F)C(F)(F)F)cc1Br)c1ccc(-n2cncn2)c([N+](=O)[O-])c1>>Nc1cc(C(=O)Nc2c(Br)cc(C(F)(C(F)(F)F)C(F)(F)C(F)(F)F)cc2Br)ccc1-n1cncn1,[Fe],CCO,O,Cl,,val
US05049671,N[C@@H]1C[C@H]1c1ccccc1.Nc1nc(Cl)c2ncn([C@H]3C=C[C@@H](CO)C3)c2n1>>Nc1nc(N[C@@H]2C[C@H]2c2ccccc2)c2ncn([C@H]3C=C[C@@H](CO)C3)c2n1,,CO,,Cl,[Na+].[OH-],val
US20080132539A1,CC(C)(C)OC(=O)N[C@@H](CCC(=O)Nc1ccccc1N)C(=O)OCc1ccccc1.CC(C)(C)c1ccc(C=O)cc1>>CC(C)(C)OC(=O)N[C@@H](CCC(=O)Nc1ccccc1NCc1ccc(C(C)(C)C)cc1)C(=O)OCc1ccccc1,,CC(Cl)Cl,,[Na+].[OH-],,val
US20100249123A1,CN(C)C(OC(C)(C)C)N(C)C.COc1cc(C)ccc1[N+](=O)[O-].NOS(=O)(=O)O>>COc1cc(CC#N)ccc1[N+](=O)[O-],,O,,,,val
US05861414,CC(C)(C)OC(=O)CN1CCC(c2n[nH]c3cc(/C=C/C4CCN(C(=O)OC(C)(C)C)CC4)ccc23)CC1.ClCc1ccc(Cl)c(Cl)c1>>CC(C)(C)OC(=O)CN1CCC(c2nn(Cc3ccc(Cl)c(Cl)c3)c3cc(/C=C/C4CCN(C(=O)OC(C)(C)C)CC4)ccc23)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20150284395A1,CCOC(=O)CC(=O)c1ccc(Cl)cc1.Cc1cnc(-c2cn[nH]c2N)s1>>Cc1cnc(-c2cnn3c(=O)cc(-c4ccc(Cl)cc4)[nH]c23)s1,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140243302A1,BrP(Br)Br.CN(C)c1nc2c(O)ccnc2cc1F>>CN(C)c1nc2c(Br)ccnc2cc1F,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20100158818A1,CC(C)(CC(=O)O)NC(=O)OCc1ccccc1.OCCN1CCCCC1>>CC(C)(CC(=O)OCCN1CCCCC1)NC(=O)OCc1ccccc1,,CN(C)C=O,,O,O=C(n1ccnc1)n1ccnc1,val
US20080319188A1,CNC1CCN(C)CC1.O=C(Oc1ccccc1)N(C(=O)Oc1ccccc1)c1cc(Oc2ccc(NC(=O)C3(C(=O)Nc4ccccc4F)CC3)c(F)c2)ccn1>>CN1CCC(N(C)C(=O)Nc2cc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccccc5F)CC4)c(F)c3)ccn2)CC1,,CN(C)C=O,,,,val
US20150315198A1,Cc1cc(C)n(Cc2ccc(Cn3cc4c(Cl)ncnc4n3)cc2)n1.N>>Cc1cc(C)n(Cc2ccc(Cn3cc4c(N)ncnc4n3)cc2)n1,,C1COCCO1,,,,val
US20040167357A1,CS(=O)(=O)Nc1ccc([C@@H]2CCC(=O)O2)cc1>>CS(=O)(=O)Nc1ccc([C@@H]2CCC(O)O2)cc1,,Cc1ccccc1,ClCCl,CC(C)C[AlH]CC(C)C,,val
US05223498,CCCCN=C(Nc1ccccc1N1CCOCC1)SC.CN>>CCCCNC(=Nc1ccccc1N1CCOCC1)NC,,CCO,,I,,val
US20130252941A1,Clc1ccncc1Br.O=Cc1cncc(Cl)c1Cl>>O=Cc1cncc(Br)c1Cl,,CN(C)C=O,,,,val
US20110201604A1,CN(C)C(=O)CN.COCCn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)O)ccc21>>COCCn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)NCC(=O)N(C)C)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060252931A1,COC(=O)[C@@H](Cc1cc(C)c(N)c(N)c1)OC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1.COC(OC)(OC)OC>>COC(=O)[C@@H](Cc1cc(C)c2[nH]c(OC)nc2c1)OC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120040978A1,CCOC(=O)c1nn(Cc2ccc(-n3cccn3)cc2)c2ccsc2c1=S.NN>>O=c1[nH]nc2c3sccc3n(Cc3ccc(-n4cccn4)cc3)nc1-2,,CCO,,,,val
US20070197598A1,C1CCNC1.C[C@H](NC1=NC(=O)C(C)(c2ccc(C(=O)Cl)cc2)S1)c1ccc(F)cc1>>C[C@H](NC1=NC(=O)C(C)(c2ccc(C(=O)N3CCCC3)cc2)S1)c1ccc(F)cc1,,ClCCl,,O,,val
US20070167406A1,C=C1CC(=O)O1.CC(O)CN1CCOCC1>>CC(=O)CC(=O)OC(C)CN1CCOCC1,,Cc1ccccc1,,CCN(CC)CC,,val
US05049699,CCCCCCCCO.O=C(O)CC1(CC(=O)O)OCOC1=O>>CCCCCCCCC(C(=O)O)C(O)(CC(=O)O)C(=O)O,,CCO,,CCN(CC)CC,,val
US04670421,CC(C)(C)OC(=O)N(CCCCCCCCCCCCCC[Si](C)(C)C)c1ccc(C(=O)c2c[nH]cn2)cc1.NCC(O)CO>>C[Si](C)(C)CCCCCCCCCCCCCCNc1ccc(C(=O)NCC(O)CO)cc1,,ClC(Cl)Cl,,[Na+].[OH-],,val
US20100130474A1,BrCCCBr.COC(=O)C(C)C(=O)OC>>COC(=O)C(C)(CCCBr)C(=O)OC,,CCCCCC,,[Na+].[OH-],,val
US20080293753A1,CN.COC(=O)[C@]1(CC=O)CC[C@H](c2ccc(OCc3ccccc3F)cc2)N1C(=O)OC(C)(C)C>>CNCC[C@@]1(C(=O)OC)CC[C@H](c2ccc(OCc3ccccc3F)cc2)N1C(=O)OC(C)(C)C,,CO,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05523400,Nc1nc(/C(=N/OC(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(/C=C4/CN(c5ccccc5)C4=O)CS[C@H]23)cs1>>Nc1nc(/C(=N/O)C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(/C=C4/CN(c5ccccc5)C4=O)CS[C@H]23)cs1,,O=CO,,,,val
US20020107248A1,COc1ccc(CC(C)C(=O)O)cc1>>COc1ccc2c(c1)C(=O)C(C)C2,,O,,,,val
US20090306066A1,BrCc1ccccc1.CN1C(=O)CNC(=O)C12CC2>>CN1C(=O)CN(Cc2ccccc2)C(=O)C12CC2,,CN(C)C=O,O,[H-].[Na+],,val
US20120252777A1,COCC1CCCN1c1cccc(N)c1.Clc1nc(Cl)c2ncsc2n1>>COCC1CCCN1c1cccc(Nc2nc(Cl)nc3scnc23)c1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US20090036492A1,CCC=Cc1ccc2ccccc2c1Br.CN(C)C=O>>CCC=Cc1ccc2ccccc2c1C=O,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US04610827,CC(C)C(N)C(=O)O.O=C(O)C[C@H](NC(=O)OCc1ccccc1)C(=O)O>>CC(C)[C@H](N)C(=O)O.O=C(O)C[C@H](NC(=O)OCc1ccccc1)C(=O)O,,O,,O=S(=O)(O)O,,val
US20080312248A1,O=[N+]([O-])c1ccc(OCCN2CCCC2)cc1F>>Nc1ccc(OCCN2CCCC2)cc1F,[Pd],CO,,,,val
US20100121048A1,CC(C)(C)OC(=O)NC1CCCN(c2ccccc2)C1=O.O=C(O)C(F)(F)F>>NC1CCCN(c2ccccc2)C1=O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05399542,CCC(=O)C1=C(O)CC(c2ccc3c(c2)N(COC)C(=O)CO3)CC1=O.CCON>>CCON=C(CC)C1=C(O)CC(c2ccc3c(c2)N(COC)C(=O)CO3)CC1=O,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20040266782A1,CC(C)[C@@H](N)CN1CCN(Cc2ccc(Cl)c(Cl)c2)CC1.O=S(=O)(Cl)c1ccc(F)cc1>>CC(C)[C@H](CN1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)NS(=O)(=O)c1ccc(F)cc1,,ClCCl,,CCN(CC)CC,,val
US20110105509A1,COC(=O)CBr.Cc1c(-c2cn(Cc3ccccc3)c(=O)c3ccccc23)c2ccccc2n1C(=O)OC(C)(C)C>>Cc1c(-c2cn(Cc3ccccc3)c(=O)c3ccccc23)c2ccccc2n1CC(=O)O,,CCOC(C)=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20080039440A1,CN.O=C(Nc1cccc(C(F)(F)F)c1)N1CCCCc2cc(Oc3cc(Cl)ncn3)ccc21>>CNc1cc(Oc2ccc3c(c2)CCCCN3C(=O)Nc2cccc(C(F)(F)F)c2)ncn1,,C1CCOC1,,,,val
US20080132514A1,CN1CCN(CC(O)c2ccccc2)CC1.Oc1ccc(F)cc1>>CN1CCN(CC(Oc2ccc(F)cc2)c2ccccc2)CC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06087380,CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ncc(C(=N)N)s1)n2C)c1ccccn1>>Cn1c(CNc2ncc(C(=N)N)s2)nc2cc(C(=O)N(CCC(=O)O)c3ccccn3)ccc21,,CO,ClCCl,Cl,[Na+].[OH-],val
US20140343278A1,CCOC(=O)CBr.Cn1c(=O)ccc2cc(OCCCNCc3ccncc3)ccc21>>CCOC(=O)CN(CCCOc1ccc2c(ccc(=O)n2C)c1)Cc1ccncc1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04814325,CCOC(=O)C1SCSCC12OCCO2>>O=C(O)C1SCSCC12OCCO2,,CCO,O,[Na+].[OH-],,val
US20070254913A1,COc1ccc(-c2ccnn2-c2ccc(C#N)cc2)cc1O[C@@H]1CCOC1.[N-]=[N+]=[N-]>>COc1ccc(-c2ccnn2-c2ccc(-c3nnn[nH]3)cc2)cc1O[C@@H]1CCOC1,,CN(C)C=O,,[Cl-].[NH4+],,val
US04021441,CCSc1cccc2c1C(c1cccc(Cl)c1)=NCc1nnc(CCl)n1-2.NCC1CC1>>CCSc1cccc2c1C(c1cccc(Cl)c1)=NCc1nnc(CNCC3CC3)n1-2,,C1CCOC1,,Cl,[K+].[OH-],val
US20150018335A1,C[C@@H]1CN(Cc2ccc(N3CCOCC3)cc2F)CCN1C(=O)OC(C)(C)C>>C[C@@H]1CN(Cc2ccc(N3CCOCC3)cc2F)CCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080021032A1,COC(C)(C)Cn1ccc([N+](=O)[O-])n1>>COC(C)(C)Cn1ccc(N)n1,[Pd],CCO,,[H][H],,val
US20150274777A1,C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(O)C(=O)N(C)Cc1ccccc1>>C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)N(C)Cc1ccccc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090054405A1,CC(=O)Nc1nc2ccc(C3OC(C)(C)C(C)(C)O3)cc2s1.O=S(=O)(Nc1cccc(Cl)n1)c1ccccc1>>Nc1nc2ccc(-c3cccc(NS(=O)(=O)c4ccccc4)n3)cc2s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20110021497A1,CC(=O)Cl.Nc1nc2ccc(Br)cn2n1>>CC(=O)Nc1nc2ccc(Br)cn2n1,,CC#N,,CCN(CC)CC,,val
US20120157439A1,CCCS(=O)(=O)Nc1ccc(Cl)c(NC(=O)c2csc3c(Cl)ncnc23)c1Cl.N>>CCCS(=O)(=O)Nc1ccc(Cl)c(NC(=O)c2csc3c(N)ncnc23)c1Cl,,CC(C)O,,,,val
US20100099695A1,COC(=O)CC(=O)OC.Nc1ncccc1C=O>>COC(=O)c1cc2cccnc2nc1O,,CO,,C[O-].[Na+],,val
US20090163524A1,O=C1NC(=O)c2ccccc21.OC(Cc1nccn1C(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1>>O=C1c2ccccc2C(=O)N1C(Cc1nccn1C(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100010239A1,O=C(/C=C/[C@@H]1[C@H]2CC(=O)O[C@H]2C[C@H]1OC(=O)c1ccccc1)CCc1ccccc1>>O=C1C[C@H]2[C@H](C[C@@H](OC(=O)c3ccccc3)[C@@H]2/C=C/[C@@H](O)CCc2ccccc2)O1,,C1CCOC1,,CO,,val
US05750213,O=C(O)C(CCCCCCOCc1ccccc1)CCCCCCOCc1ccccc1.OCCCCCCOc1ccc(-c2cccc(F)c2F)cc1>>O=C(OCCCCCCOc1ccc(-c2cccc(F)c2F)cc1)C(CCCCCCOCc1ccccc1)CCCCCCOCc1ccccc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050070580A1,CC(=O)NCC1CN(c2cc(F)c(C(=O)OC(C)(C)C)c(F)c2)C(=O)O1>>CC(=O)NCC1CN(c2cc(F)c(C(=O)O)c(F)c2)C(=O)O1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150266864A1,NN.O=C(C(=CO)CCN1CCOCC1)c1ccc(F)cc1>>Fc1ccc(-c2n[nH]cc2CCN2CCOCC2)cc1,,CCO,,O,O,val
US20160272596A1,CC(C)(C)OC(=O)N[C@H]1CN(C(=O)c2ccc([N+](=O)[O-])cc2)c2ccccc2NC1=O.COc1ccc2ccccc2c1CCl>>COc1ccc2ccccc2c1CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CN(C(=O)c2ccc([N+](=O)[O-])cc2)c2ccccc21,,CN(C)C=O,O,[I-].[Na+],O=C([O-])[O-].[Cs+].[Cs+],val
US05238939,CCC1(CCCl)OCCc2cc(OC)c(OC)cc21.O=C(O)/C=C/C(=O)O.c1ccc(C(CCCN2CCNCC2)c2ccccc2)cc1>>CCC1(CCN2CCN(CCCC(c3ccccc3)c3ccccc3)CC2)OCCc2cc(OC)c(OC)cc21.O=C(O)/C=C/C(=O)O,,CCO,CN(C)C=O,Cl,[I-].[K+],val
US20150361068A1,C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1CCCN.Clc1ncccn1>>C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1CCCNc1ncccn1,,CC(C)O,,,,val
US20140213578A1,Clc1ccc2c(c1)CCc1ccccc1N2.O=C(Cl)CCl>>O=C(CCl)N1c2ccccc2CCc2cc(Cl)ccc21,,Cc1ccccc1,,,,val
US20060270632A1,Cc1ccc(NC2CCN(CCC3(CCN4CCOCC4)CCCCC3)CC2)cc1.O=C(Cl)c1ccco1>>Cc1ccc(N(C(=O)c2ccco2)C2CCN(CCC3(CCN4CCOCC4)CCCCC3)CC2)cc1,,ClCCl,,CCN(CC)CC,,val
US20150150999A1,CC(C)Cc1ccc(C(C)C(=O)O)cc1.O=C(OC1COC(c2ccccc2)OC1)c1ccc(O)cc1>>CC(C)Cc1ccc(C(C)C(=O)Oc2ccc(C(=O)OC3COC(c4ccccc4)OC3)cc2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060217380A1,Cc1c(CN2CCN(C)CC2)cccc1[N+](=O)[O-]>>Cc1c(N)cccc1CN1CCN(C)CC1,[Pd],CO,,CCO,,val
US20070254867A1,COc1cc(Cl)ccc1I.c1c[nH]cn1>>COc1cc(Cl)ccc1-n1ccnc1,[Cu]I,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100113547A1,CN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(CO)c1ccccc1.O=C1CCC(=O)O1>>CN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(COC(CC=O)C(=O)O)c1ccccc1,,c1ccncc1,,CN(C)c1ccccn1,,val
US20090036431A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1cc(OCCOCCOCCN=[N+]=[N-])cc(C(=O)OCC)n1>>CCOC(=O)c1cc(OCCOCCOCCNC(=O)OC(C)(C)C)cc(C(=O)OCC)n1,[Pd],CCOC(C)=O,,,,val
US20110077400A1,COc1cccc(CN(C)CC(=O)c2ccc3ccccc3c2)c1>>COc1cccc(CN(C)CC(O)c2ccc3ccccc3c2)c1,,CO,,[BH4-].[Na+],,val
US20150322056A1,C1CNC1.Clc1cc(-n2ccc(I)n2)cnn1>>Ic1ccn(-c2cnnc(N3CCC3)c2)n1,,C1COCCO1,CCOC(C)=O,,,val
US20130281433A1,C[Mg]Br.O=Cc1cc(Br)ccn1>>CC(O)c1cc(Br)ccn1,,CCOCC,,C1CCOC1,,val
US20120329780A1,CN1CCN(c2ccc(N)cc2)CC1.COc1ccc(Cn2cc3nc(-c4cccc(-c5nn[nH]n5)c4)nc(Cl)c3n2)cc1>>CN1CCN(c2ccc(Nc3nc(-c4cccc(-c5nn[nH]n5)c4)nc4cn[nH]c34)cc2)CC1,C1COCCO1,CO,,Cl,,val
US05234907,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(O)ccc1C[C@H](N)C(=O)O>>COc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc1,,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20160221945A1,O=C1NC(=O)c2ccccc21.OCc1cc(-c2ccc(C(F)(F)F)nc2)c(Cl)cn1>>O=C1c2ccccc2C(=O)N1Cc1cc(-c2ccc(C(F)(F)F)nc2)c(Cl)cn1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070167452A1,C=CCCCC(=O)N1C(=O)OC[C@H]1C(C)C.ClCOCc1ccccc1>>C=CCC[C@@H](COCc1ccccc1)C(=O)N1C(=O)OC[C@H]1C(C)C,Cl[Ti](Cl)(Cl)Cl,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100234357A1,COCCBr.Cc1ccc(N2CCN(c3c(C)c(O)c4c(c3C)CC(C)(C)O4)CC2)cc1>>COCCOc1c(C)c(N2CCN(c3ccc(C)cc3)CC2)c(C)c2c1OC(C)(C)C2,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160068489A1,Cc1nc(N)c(C)c(C)c1OCc1ccccc1.O=C(Cl)c1ccc2c(c1)OCO2>>Cc1nc(NC(=O)c2ccc3c(c2)OCO3)c(C)c(C)c1OCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20030153736A1,[N-]=[N+]=NC[C@H](O)[C@H]1OC(=O)C(OCc2ccccc2)=C1OCc1ccccc1>>NC[C@H](O)[C@H]1OC(=O)C(OCc2ccccc2)=C1OCc1ccccc1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100105664A1,CCOC(=O)c1cc(-c2ccnc(/C=C/c3ccccc3)c2)[nH]c1C1CCN(C(=O)OC(C)(C)C)CC1>>CC(C)(C)OC(=O)N1CCC(c2[nH]c(-c3ccnc(/C=C/c4ccccc4)c3)cc2C(=O)O)CC1,,CO,,[Na+].[OH-],,val
US20010039344A1,Nc1ncccn1.O=C(O)C(CC1CCCC1)c1ccc(Cl)c(Cl)c1>>O=C(Nc1ncccn1)C(CC1CCCC1)c1ccc(Cl)c(Cl)c1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20100249119A1,CC(=O)Cl.CC(C)(C)OC(=O)Nc1cc(Nc2ncc3nc(N)sc3n2)c(Cl)cc1F>>CC(=O)Nc1nc2cnc(Nc3cc(NC(=O)OC(C)(C)C)c(F)cc3Cl)nc2s1,,c1ccncc1,,O=C([O-])O.[Na+],,val
US20150239895A1,CC(C)(C)OC(=O)Cn1nc(C(N)=O)c2cc(Cl)ncc21.OB(O)c1cncnc1>>NC(=O)c1nn(CC(=O)O)c2cnc(-c3cncnc3)cc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20010027196A1,Cc1ccc(CNc2nc(N)nc(-c3ccco3)c2C#N)nc1.O=C1CCC(=O)N1Br>>Cc1ccc(CNc2nc(N)nc(-c3ccc(Br)o3)c2C#N)nc1,,CN(C)C=O,,,,val
US20040209892A1,Clc1ccnc2ccccc12.Nc1ccc(O)c([N+](=O)[O-])c1>>O=[N+]([O-])c1cc(Nc2ccnc3ccccc23)ccc1O,,CC(C)O,,O=C(O)C(F)(F)F,,val
US20020093005A1,COc1cc(C(=O)O)c(Br)cc1C(=O)O.c1ccc2c(c1)[nH]c1ccccc12>>COc1cc(C(=O)O)c(-n2c3ccccc3c3ccccc32)cc1C(=O)O,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US04666510,CC(=O)c1c(C)cc(C)c(C2CC(=O)C=C(O)C2)c1C.CCC(=O)OC(=O)CC>>CCC(=O)C1=C(O)CC(c2c(C)cc(C)c(C(C)=O)c2C)CC1=O,,CN(C)C=O,,O,[Na+].[OH-],val
US20090181963A1,CCn1nnc2c(N3CCOCC3)nc(-c3ccc(N)cc3)nc21.Nc1ccncc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21,,ClCCl,,CCN(CC)CC,,val
US05144045,C=C(C)C(F)(F)CCCCCCCCCCCCCCCC.O=C1CCC(=O)N1Br>>C=C(CBr)C(F)(F)CCCCCCCCCCCCCCCC,,ClC(Cl)(Cl)Cl,,,,val
US20100029687A1,C[C@H](c1cccc2ccccc12)N(CC1CCN(C(=O)CCC(=O)Nc2ccc(C(=O)O)cc2)CC1c1cccc(F)c1)C(=O)OC(C)(C)C.Cl>>C[C@@H](NCC1CCN(C(=O)CCC(=O)Nc2ccc(C(=O)O)cc2)CC1c1cccc(F)c1)c1cccc2ccccc12.Cl,,CCOC(C)=O,,CC(C)OC(C)C,,val
US20020068721A1,CC(C)(C)[Si](C)(C)Cl.OCCc1cccc(O)c1>>CC(C)(C)[Si](C)(C)Oc1cccc(CCO)c1,,ClCCl,,c1ccncc1,,val
US20150239900A1,CC(=O)Cl.COC(=O)c1cc(I)c(Cl)c(F)c1N>>CC(=O)Nc1cc(Cl)c(I)cc1C(C)=O,,ClCCl,,c1ccncc1,,val
US20010036946A1,CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCN(c2ccncc2)CC1.ClCCl>>CN(C)CCCC[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCN(c2ccncc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140371199A1,CC1(C)OB(c2ccc3ncc(-c4ccc(C#N)cc4)n3c2)OC1(C)C.COc1cc(Br)ccc1C(=O)N1CCN(C(=O)OC(C)(C)C)CC1>>COc1cc(-c2ccc3ncc(-c4ccc(C#N)cc4)n3c2)ccc1C(=O)N1CCN(C(=O)OC(C)(C)C)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20110269956A1,CCCCOC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1nc(-c2ccc3cc(C#Cc4c[nH]c([C@@H]5C[C@H]6C[C@H]6N5C(=O)OC(C)(C)C)n4)ccc3c2)c[nH]1.Cl>>C(#Cc1c[nH]c([C@@H]2C[C@H]3C[C@H]3N2)n1)c1ccc2cc(-c3cnc([C@@H]4C[C@H]5C[C@H]5N4)[nH]3)ccc2c1.Cl,,C1COCCO1,,,,val
US20100280071A1,C#CCO[C@@H]1CC[C@@H](N2CCC(Nc3cc(C)ccc3N)CC2)CC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C#CCO[C@@H]1CC[C@@H](N2CCC(n3c(=O)[nH]c4ccc(C)cc43)CC2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110281870A1,NC1CC[C@H]2CN(Cc3cccc(C(F)(F)F)c3)C[C@@H]12.O=S(=O)(Cl)c1cccc(C(F)(F)F)c1>>O=S(=O)(N[C@H]1CC[C@H]2CN(Cc3cccc(C(F)(F)F)c3)C[C@H]21)c1cccc(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,,val
US04279902,C=CCOCC1CCC(CO)O1.CCCN(CCC)C(=O)CCl>>C=CCOCC1CCC(COCC(=O)N(CCC)CCC)O1,,CS(C)=O,,O,[H-].[Na+],val
US04618677,CCCCc1ccc(N=C=O)cc1.Cl.Cl.SCCCN1CCN(Cc2ccc(Cl)cc2)CC1>>CCCCc1ccc(NC(O)=[SH]CCCN2CCN(Cc3ccc(Cl)cc3)CC2)cc1.Cl.Cl,,ClCCl,,CCN(CC)CC,,val
US20050187224A1,CCOC(=O)CC(=O)OCC.N#Cc1ccc(Br)c(Cl)c1>>COC(=O)C(C(=O)OC)c1ccc(C#N)cc1Cl,[Cu]Br,C1COCCO1,O,Cl,[H-].[Na+],val
US20100137362A1,Cc1cc(Cl)ncc1N.O=C1CCC(=O)N1I>>Cc1cc(Cl)nc(I)c1N,,CN(C)C=O,,CCOC(C)=O,,val
US20110053936A1,CCOC(=N)c1ccc(C)c(I)c1.NNC(=O)C(F)(F)F>>Cc1ccc(-c2nnc(C(F)(F)F)[nH]2)cc1I,,CO,,,,val
US20010004669A1,CN1CCN(c2cccc3ccc(Nc4ncccc4N)cc23)CC1.O=C(Cl)c1ccccc1>>CN1CCN(c2cccc3ccc(Nc4ncccc4NC(=O)c4ccccc4)cc23)CC1,,C1CCOC1,,CCN(CC)CC,,val
US05646308,CI.CNC(=O)C1=CC2(CCOCC2)Oc2ccc([N+](=O)[O-])cc21>>CN(C)C(=O)C1=CC2(CCOCC2)Oc2ccc([N+](=O)[O-])cc21,,CN(C)C=O,,[H-].[Na+],,val
US20090099181A1,CCOC(=O)c1cncc(C#Cc2ccccc2)c1>>O=C(O)c1cncc(C#Cc2ccccc2)c1,,CO,O,[Na+].[OH-],,val
US20140066443A1,CC(C)Cn1nnc2c(Br)c(-c3ccc(CCl)cc3)ccc21.CN1C(=O)CNC1=O>>CC(C)Cn1nnc2c(Br)c(-c3ccc(CN4CC(=O)N(C)C4=O)cc3)ccc21,,CC#N,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20120202785A1,ClCc1nc2ccccc2n1-c1ccccc1.Clc1ncnc2[nH]ccc12>>Clc1ncnc2c1ccn2Cc1nc2ccccc2n1-c1ccccc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150133510A1,COc1ccc(C=O)cc1.NCc1ccncc1>>COc1ccc(CNCc2ccncc2)cc1,,CO,,[BH3-]C#N.[Na+],,val
US20150376225A1,C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@H](C(=O)O)[C@@]3(C)C[C@H](O)[C@@H]12>>C[C@]12CCC(=O)CC1CC[C@H]1[C@@H]3CC[C@H](C(=O)O)[C@@]3(C)C[C@H](O)[C@@H]12,[Pd],CCOC(C)=O,,,,val
US20080269193A1,CS(=O)(=O)Cl.Cc1nn(-c2ccc(C(N)=O)c(Nc3cnn(CCO)c3)c2)c2c1C(=O)CC(C)(C)C2>>Cc1nn(-c2ccc(C(N)=O)c(Nc3cnn(CCOS(C)(=O)=O)c3)c2)c2c1C(=O)CC(C)(C)C2,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20060128770A1,CC(=O)Nc1nc(CCc2ccc(N)c(N)c2)c(Cc2ccc(S(C)(=O)=O)cc2)s1.N#CBr>>CC(=O)Nc1nc(CCc2ccc3nc(N)[nH]c3c2)c(Cc2ccc(S(C)(=O)=O)cc2)s1,,CCOCC,CO,ClCCl,[Na+].[OH-],val
US20140256700A1,BrC(c1ccccc1)c1ccccc1.COC(=O)c1ccc2c(c1)[nH]c1cc(Br)cc(C#N)c12>>COC(=O)c1ccc2c3c(C#N)cc(Br)cc3n(C(c3ccccc3)c3ccccc3)c2c1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100048727A1,COC(=O)C(O)CCCc1ccccc1.COCCN(CCOC)S(F)(F)F>>COC(=O)C(F)CCCc1ccccc1,,ClCCl,,,,val
US20040147543A1,CCOC(=O)CC(=O)OCC.Nc1ccccc1Br>>O=C(O)CC(=O)Nc1ccccc1Br,,CO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20150111914A1,C=O.CCOP(=O)(OCC)C(C(=O)OC(C)(C)C)C(C)c1ccc(C(=O)OC)cc1>>C=C(C(=O)OC(C)(C)C)C(C)c1ccc(C(=O)OC)cc1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US08912186B2,Cl.Nc1ccc(I)cc1N.O=C1CC(c2ccc(-c3ccccc3)cc2)CC(=O)O1>>Cl.O=C(O)CC(Cc1nc2ccc(I)cc2[nH]1)c1ccc(-c2ccccc2)cc1,,C1COCCO1,ClCCl,,,val
US20110136871A1,N#Cc1c(Cl)nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1cncs1.OCCCO>>N#Cc1c(OCCCO)nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1cncs1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20150152127A1,C=CCO[C@@H]1[C@@H](C=O)O[C@@H]2SC(N(C)C(=O)OC(C)(C)C)=N[C@@H]2[C@H]1OCC=C.C[Si](C)(C)C(F)(F)F>>C=CCO[C@H]1[C@H](OCC=C)[C@H]2N=C(N(C)C(=O)OC(C)(C)C)S[C@H]2O[C@@H]1[C@@H](O)C(F)(F)F,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05045552,CC(=O)OC(C)=O.Cc1c(OCCOCc2ccccn2)cc[n+]([O-])c1C>>CC(=O)OCc1nccc(OCCOCc2ccccn2)c1C,,CCO,,,,val
US20120228583A1,Nc1cccc(-c2ccccc2)c1.O=[N+]([O-])c1cccnc1Cl>>O=[N+]([O-])c1cccnc1Nc1cccc(-c2ccccc2)c1,,CCCCO,,CCN(CC)CC,,val
US20100137386A1,COc1ccc(Nc2nc(C(N)=O)c(N)s2)cc1.O=C(Cl)c1ccc(F)cc1>>COc1ccc(Nc2nc(C(N)=O)c(NC(=O)c3ccc(F)cc3)s2)cc1,,CCOC(C)=O,c1ccncc1,,,val
US20050085667A1,CI.COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(N)CC2)cc1>>CNC1(C(=O)NCc2ccc(-c3ccccc3C(=O)OC)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20020032168A1,CC(C)CC=O.CCC(CC)NCCNC(=O)OCc1ccccc1>>CCC(CC)N(CCNC(=O)OCc1ccccc1)CC(C)C,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20030134867A1,CSc1nccc(C(=O)N2CC(OC(=O)C(C)(C)C)CN2C(=O)Cc2ccc(F)cc2)n1>>CSc1nccc(-c2c(-c3ccc(F)cc3)c(=O)n3n2CC(OC(=O)C(C)(C)C)C3)n1,,C1CCOC1,,[H-].[Na+],,val
US20090111847A1,C=C(C)C=O.O=[N+]([O-])C=C1NCCN1Cc1ccc(Cl)nc1>>CC1CC([N+](=O)[O-])=C2N(Cc3ccc(Cl)nc3)CCN2C1O,,CC(=O)O,,CC#N,,val
US20130237545A1,BrP(Br)Br.OCc1coc(-c2c(-c3ccccc3)cnnc2-c2ccccc2)n1>>BrCc1coc(-c2c(-c3ccccc3)cnnc2-c2ccccc2)n1,,ClCCl,,,,val
US20130150353A1,CC(C)(C)OC(=O)N1C2COCC1CC(c1cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3nccc3n1)C2.O=C1CCC(=O)N1I>>CC(C)(C)OC(=O)N1C2COCC1CC(c1cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3ncc(I)c3n1)C2,,CC#N,,,,val
US04408076,COC(=CCO)C(C)Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1>>C=CC(=O)C(C)Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1,,ClCCl,,,,val
US20060040999A1,C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1cc(C(F)(F)F)ccc1-c1nc(CO[Si](C)(C)C(C)(C)C)cs1>>C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1cc(C(F)(F)F)ccc1-c1nc(CO)cs1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04518713,CCc1ccc(OC2CCNCC2)cc1.O=C(Br)CBr>>CCc1ccc(OC2CCN(C(=O)CBr)CC2)cc1,,ClCCl,,O,O=C([O-])O.[Na+],val
US03998958,CN1CCCCC1=N.O=C=Nc1ccccc1>>CN1CCCCC1=NC(=O)Nc1ccccc1,,c1ccccc1,,O,[Na+].[OH-],val
US20110144066A1,CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.CC(C)(C)c1nnc(N)s1>>CC(=O)Nc1ccc(S(=O)(=O)Nc2nnc(C(C)(C)C)s2)cc1,,c1ccncc1,,Cl,,val
US20060247287A1,C=CC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C.Nc1ccnc(-c2cc(-c3c(Cl)cccc3Cl)no2)c1>>CC(C)(C)OC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)CCNc1ccnc(-c2cc(-c3c(Cl)cccc3Cl)no2)c1,,CC#N,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20130317014A1,COC(=O)CC1(NS(=O)C(C)(C)C)CC2(CCCCC2)Oc2ccc(Br)cc21>>COC(=O)CC1(N)CC2(CCCCC2)Oc2ccc(Br)cc21,,CO,,C1COCCO1,Cl,val
US20090130090A1,CC(=O)Cl.Nc1cc(Cl)ccc1O>>CC(=O)Nc1cc(Cl)ccc1O,,C1CCOC1,,CCN(CC)CC,,val
US06806230B1,CCOC=C(C(=O)C(C)C)C(=O)C(C)C.N=CN>>CC(C)C(=O)c1cncnc1C(C)C,,CO,,CC(=O)O,C[O-].[Na+],val
US04404203,NN.O=C(O)CCC(=O)c1ccccc1>>O=C1CCC(c2ccccc2)=NN1,,CCO,,O,,val
US20100137302A1,Brc1ccc2c(c1)NCCO2.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCOc2ccc(Br)cc21,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,,val
US20100152441A1,CC(C)(C)OC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@@H]1CCN1C(=O)COc2ccc(C#N)cc21>>CC(C)(C)OC(=O)N1C[C@H](O)CC[C@@H]1CCN1C(=O)COc2ccc(C#N)cc21,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040077667A1,C=O.CC#N.Nc1cccc2c(=O)[nH]c(CCCN3CC=C(c4ccccc4)CC3)nc12>>CN(C)c1cccc2c(=O)[nH]c(CCCN3CC=C(c4ccccc4)CC3)nc12,,CC#N,,CC(=O)O,[BH3-]C#N.[Na+],val
US05681954,CCOC(=O)CCc1cc(OC)c(OC)cc1-n1cccc1.COc1ccccc1N1CCNCC1>>COc1cc(CCC(=O)N2CCN(c3ccccc3OC)CC2)c(-n2cccc2)cc1OC,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20070037817A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OC[C@H]1CC[C@H]2CNCCN12>>CC(C)(C)OC(=O)N1CCN2[C@@H](CO)CC[C@H]2C1,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US05021420,CI.O=S1(=O)c2cccc3cccc(c23)N1CC(O)CN1CCN(c2ccc(F)cc2)CC1>>COC(CN1CCN(c2ccc(F)cc2)CC1)CN1c2cccc3cccc(c23)S1(=O)=O,,CN(C)C=O,O,[H-].[Na+],,val
US20140155597A1,Cc1ccc(C(N)=O)cc1.O=C(Cl)SCl>>Cc1ccc(-c2nsc(=O)o2)cc1,,Cc1ccccc1,,,,val
US20090198063A1,NCC1OCCO1.O=[N+]([O-])c1ccc(Cl)nc1Cl>>O=[N+]([O-])c1ccc(Cl)nc1NCC1OCCO1,,CC#N,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US04230703,COC(=O)C(C)c1ccc2c(c1)C(=O)c1ccccc1CN2C.O=C1CCC(=O)N1Cl>>CC(C(=O)O)c1cc(Cl)c2c(c1)C(=O)c1ccccc1CN2C,,ClC(Cl)Cl,,,,val
US05866576,C=CCCCC(Br)CCC.Cn1ccc(=O)[nH]c1=O>>C=CCCCCCCCn1c(=O)ccn(C)c1=O,,CS(C)=O,,O,[H-].[Na+],val
US20160031871A1,CC(=O)Nc1ncc(CO)s1.O=S(Cl)Cl>>CC(=O)Nc1ncc(CCl)s1,,ClCCl,,,,val
US20100029745A1,CSc1ccc(-c2ccc(C(=O)C=Cc3ccc(O)c(Cl)c3Cl)s2)cc1>>CSc1ccc(-c2ccc(C(=O)CCc3ccc(O)c(Cl)c3Cl)s2)cc1,,C1CCOC1,,,,val
US20060069098A1,CC(c1ccc2cccccc1-2)N1C(=O)c2ccccc2C1=O>>CC(N)c1ccc2cccccc1-2,,CCO,,NN,O,val
US04943591,ClCCOCCCl.Nc1ccc(CCO)cc1>>OCCc1ccc(N2CCOCC2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,[I-].[K+],val
US20070078140A1,CN.O=C(Cl)c1cc(Cl)cnc1Cl>>CNC(=O)c1cc(Cl)cnc1Cl,,CC#N,,CCN(CC)CC,,val
US20010047006A1,CCOC(=O)[C@@H](N)Cc1ccccc1.CCOC(CBr)OCC>>CCOC(=O)[C@H](Cc1ccccc1)NCC(OCC)OCC,,CN(C)C=O,ClC(Cl)Cl,CCN(C(C)C)C(C)C,,val
US20010027196A1,Nc1nc(OS(=O)(=O)C(F)(F)F)c([N+](=O)[O-])c(-c2ccco2)n1.OCc1ccccc1>>Nc1nc(OCc2ccccc2)c([N+](=O)[O-])c(-c2ccco2)n1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US07160901B2,CN(C)CCN(c1cccc([N+](=O)[O-])c1)S(C)(=O)=O>>CN(C)CCN(c1cccc(N)c1)S(C)(=O)=O,[Pd],,,,,val
US20080039460A1,CC(=O)Cl.Nc1cccc(-c2nc3cc(NC(=O)c4ccccc4Cl)cnc3[nH]2)c1>>CC(=O)Nc1cccc(-c2nc3cc(NC(=O)c4ccccc4Cl)cnc3[nH]2)c1,,c1ccncc1,,,,val
US20030109527A1,O=C(Nc1ccc(Cl)c(S(=O)(=O)NCCOCc2ccccc2)c1O)Nc1cccc(Cl)c1Cl>>O=C(Nc1ccc(Cl)c(S(=O)(=O)NCCO)c1O)Nc1cccc(Cl)c1Cl,,ClCCl,,C[Si](C)(C)I,,val
US20120004222A1,N=C(N)c1nc(CN2CCC(F)(F)CC2)c2ccccn12.O=C(CBr)c1ccccc1>>FC1(F)CCN(Cc2nc(-c3nc(-c4ccccc4)c[nH]3)n3ccccc23)CC1,,CC(C)=O,,O=C([O-])O.[Na+],,val
US20080255383A1,COc1cccc(C(C)=O)c1.NO>>COc1cccc(C(C)=NO)c1,,CC(C)O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090326074A1,Cc1ccc(S(=O)(=O)OC[C@H]2CCCC[C@@H]2O)cc1.O=C1c2ccccc2C(=O)N1CCCc1cccc(O)c1>>O=C1c2ccccc2C(=O)N1CCCc1cccc(OC[C@H]2CCCC[C@@H]2O)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04996320,C[Si](C)(C)OS(=O)(=O)C(F)(F)F.FF.c1ccncc1>>F[n+]1ccccc1.O=S(=O)([O-])C(F)(F)F,,CCOCC,,CC#N,,val
US20030073731A1,CCOC(=O)Cc1c([N+](=O)[O-])cc([N+](=O)[O-])c2ccccc12>>CCOC(=O)Cc1c([N+](=O)[O-])cc(N)c2ccccc12,,CCO,,O,,val
US05932571,C=CCC(C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1)c1ccccc1.OO>>C=CC[C@H](C(=O)O)c1ccccc1,,O,,C1CCOC1,[Li+].[OH-],val
US20150232445A1,CC(C)(C)OC(=O)N1CC[C@H](O)[C@@H](F)C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CC[C@H](OS(C)(=O)=O)[C@@H](F)C1,,ClCCl,,CCN(CC)CC,,val
US20070004675A1,CNc1ccccc1.O=C(O)C1(C(=O)O)CC1>>CN(C(=O)C1(C(=O)O)CC1)c1ccccc1,,C1CCOC1,CCOC(C)=O,,,val
US05153318,C1CNC1.Nc1nc(Cl)c2[nH]cnc2n1>>Nc1nc(N2CCC2)c2nc[nH]c2n1,,CC#N,,,,val
US04775692,C=[N+]=[N-].O=C(O)C1CCCC1>>COC(=O)C1CCCC1,,CCOCC,,,,val
US04654362,O=C(O)c1cc(=O)c2ccc3ccccc3c2o1>>O=C(O)C1CCc2ccc3ccccc3c2O1,[Pd],COCCO,,[H][H],,val
US04118216,CC1COC(CBr)O1.CCCOC(CN)OCCC>>CCCOC(CNCC1OCC(C)O1)OCCC,,Cc1ccccc1,,CCN(CC)CC,,val
US06150352,CNOC.Cc1cc(C)cc(-c2c(OCCC3CCCCN3C(=O)OC(C)(C)C)c3cc(C(=O)O)c(Cl)cc3[nH]c2=O)c1>>CON(C)C(=O)c1cc2c(OCCC3CCCCN3C(=O)OC(C)(C)C)c(-c3cc(C)cc(C)c3)c(=O)[nH]c2cc1Cl,CN(C)c1ccncc1,CCN(CC)CC,,CCN=C=NCCCN(C)C,Cl,val
US20140378463A1,CC1c2nc(-c3ccccc3)c(-c3ccccc3)nc2CCN1C(=O)OC(C)(C)C.Cl>>CC1NCCc2nc(-c3ccccc3)c(-c3ccccc3)nc21.Cl,,CO,,C1COCCO1,,val
US20160222033A1,BrCc1ccccc1.C#CCCO>>C#CCCOCc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20080269293A1,CC(O)c1ccc([N+](=O)[O-])cc1.CI>>COC(C)c1ccc([N+](=O)[O-])cc1,,C1CCOC1,,[H-].[Na+],,val
US20030114443A1,CC(C)(C)OC(=O)N1CCC(Cc2ccc(F)cc2)CC1.Cl>>Cl.Fc1ccc(CC2CCNCC2)cc1,,CCOC(C)=O,,,,val
US20120101093A1,CCOC(=O)c1cn2c(C)c(Br)ccc2n1.O[C@@H]1CCNC1>>CCOC(=O)c1cn2c(C)c(N3CC[C@@H](O)C3)ccc2n1,[Pd],CN1CCCC1=O,,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20050187209A1,CC(C)(C)OC(=O)c1cc2c(N)n[nH]c2s1.CCOC(=O)Cl>>CCOC(=O)n1nc(N)c2cc(C(=O)OC(C)(C)C)sc21,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20140213571A1,CC(C)OB(OC(C)C)OC(C)C.COc1ccc2c(ccn2C(=O)OC(C)(C)C)n1>>COc1ccc2c(cc(B(O)O)n2C(=O)OC(C)(C)C)n1,,C1CCOC1,,[Li]C(C)(C)C,,val
US20090318428A1,Nc1cnc2[nH]ccc2c1.O=C(Cl)c1cc([N+](=O)[O-])ccc1Cl>>O=C(Nc1cnc2[nH]ccc2c1)c1cc([N+](=O)[O-])ccc1Cl,,ClCCl,c1ccncc1,,,val
US20030199458A1,COC(=O)C(Br)c1ccccc1.OB(O)c1ccco1>>COC(=O)Cc1cccc(-c2ccco2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20050256158A1,CC(=O)Cl.COc1ccc(C(=O)N2c3ccccc3[C@H](Nc3ccncc3)C[C@@H]2C)cc1>>COc1ccc(C(=O)N2c3ccccc3[C@H](N(C(C)=O)c3ccncc3)C[C@@H]2C)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120028919A1,CSc1ncc2c(O)ccn2n1.C[Si](C)(C)CCOCCl>>CSc1ncc2c(OCOCC[Si](C)(C)C)ccn2n1,,CN(C)C=O,CN(C)C=O,[H-].[Na+],,val
US20060287341A1,FC(F)(F)c1ccc(CCl)cn1.O=c1[nH]nc2cc(-c3ccc(Cl)cc3)ncn12>>O=c1n(Cc2ccc(C(F)(F)F)nc2)nc2cc(-c3ccc(Cl)cc3)ncn12,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3nc(-n4cccn4)[nH]c3c2)cc1.Cl>>Cc1cc(C(=O)NC2CCNCC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc3nc(-n4cccn4)[nH]c3c2)cc1.Cl,,C1COCCO1,,,,val
US20110065702A1,C[Mg]Br.O=Cc1ccc2cn[nH]c2c1>>CC(O)c1ccc2cn[nH]c2c1,,C1CCOC1,,,,val
US20100324040A1,C[C@H](NC(=O)OC(C)(C)C)c1ccc(F)cn1.Cl>>C[C@H](N)c1ccc(F)cn1.Cl,,ClCCl,,C1COCCO1,,val
US07632840B2,CC(C)OC[C@H](NC(=O)OCc1ccccc1)C(=O)O.N>>CC(C)OC[C@H](NC(=O)OCc1ccccc1)C(N)=O,,C1CCOC1,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20060264428A1,C=O.C[C@H](c1ccccc1)N1CC(C(=O)OC(C)(C)C)CC1=O>>C[C@H](c1ccccc1)N1C[C@@](CO)(C(=O)OC(C)(C)C)CC1=O,,CN(C)C=O,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20160102071A1,CC#C[C@@H](CC(=O)OCC)c1ccc(COc2ccc3scc(-c4ccc(OCCOC)cc4C)c3c2)cc1>>CC#C[C@@H](CC(=O)O)c1ccc(COc2ccc3scc(-c4ccc(OCCOC)cc4C)c3c2)cc1,,CCO,,Cl,[Li+].[OH-],val
US20110065708A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.CC(c1c(F)cc2ncccc2c1F)n1nnc2ncc(Br)nc21>>C=C(OCC)c1cnc2nnn(C(C)c3c(F)cc4ncccc4c3F)c2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20030153557A1,COC(=O)C=Cc1ccc(C(=O)O)s1>>COC(=O)CCc1ccc(C(=O)O)s1,[Pd],CO,,,,val
US20110311474A1,Cc1ccc(S(=O)(=O)n2ccc3c(NC4CCCCC4)c(N)cnc32)cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1ccc(S(=O)(=O)n2ccc3c(NC4CCCCC4)c(NC(=O)C(F)(F)F)cnc32)cc1,,ClCCl,,,,val
US20090209536A1,NCc1nc(N2CCCC2)c2ccccc2n1.O=S(=O)(Cl)c1cccc2ccccc12>>O=S(=O)(NCc1nc(N2CCCC2)c2ccccc2n1)c1cccc2ccccc12,,C1CCOC1,,c1ccncc1,,val
US20010029256A1,CCOC(=O)C(Cc1ccc(OCCNC2=Nc3ccccc3Sc3ccccc32)cc1)OCC>>CCOC(Cc1ccc(OCCNC2=Nc3ccccc3Sc3ccccc32)cc1)C(=O)O,,CCO,,[Na+].[OH-],,val
US20080090834A1,CC(=O)c1ccccn1.COC(=O)c1cccnc1>>O=C(CC(=O)c1ccccn1)c1cccnc1,,C1CCOC1,,C[O-].[Na+],,val
US04367238,COc1ccccc1Oc1cccc(CBr)c1OC.[C-]#N>>COc1ccccc1Oc1cccc(CC#N)c1OC,,CS(C)=O,,O,,val
USRE029836,CCOC(=O)C1=C(O)c2ccccc2S(=O)(=O)N1C.Cc1cc(N)no1>>Cc1cc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2)no1,,Cc1ccccc1C,,,,val
US20060135578A1,COC(=O)c1cccc(-c2nc(CCl)c(C)o2)c1.O=Cc1ccc(O)cc1>>COC(=O)c1cccc(-c2nc(COc3ccc(C=O)cc3)c(C)o2)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070082912A1,CCOC(=O)c1cncc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(Cl)cc2)c1>>Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(Cl)cc2)n1-c1cncc(C(=O)O)c1,,CCOC(C)=O,,CCO,,val
US20100041658A1,CCc1ccc(Oc2ccc(N3C(=O)CCC3=O)cc2F)c(OC)c1>>CCc1ccc(Oc2ccc(NC(=O)CCCO)cc2F)c(OC)c1,,CC#N,,CO,[BH4-].[Na+],val
US20130143860A1,Clc1ncc(Br)cn1.OC1CCOCC1>>Brc1cnc(OC2CCOCC2)nc1,,CCOC(C)=O,O,C1CCOC1,[H-].[Na+],val
US04472305,CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)OC(C)(C)C)C(N)=O>>CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1)C(N)=O,,CC(=O)O,,Cl,,val
US20010056090A1,CC(C)(C)OC(=O)N1CCC[C@@H](Nc2ccccc2N)C1.O=C(Cl)Cl>>CC(C)(C)OC(=O)N1CCC[C@@H](n2c(=O)[nH]c3ccccc32)C1,,ClCCl,,CCN(CC)CC,,val
US05334485,O=Cc1ccc(C=Cc2ccnc3ccccc23)cc1>>OCc1ccc(C=Cc2ccnc3ccccc23)cc1,,CCOCC,CO,[BH4-].[Na+],,val
US20150126490A1,CC(C)(C)OC(=O)c1ccc(-c2nc([C@@H]3CC[C@@H](O)[C@H](F)C3)cnc2N)cc1F>>Nc1ncc([C@@H]2CC[C@@H](O)[C@H](F)C2)nc1-c1ccc(C(=O)O)c(F)c1,,ClCCl,,C1COCCO1,Cl,val
US20090156612A1,N[C@H]1CCCC[C@@H]1n1cnc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2Cc2cc(F)cc(F)c2)c1-c1ccccc1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.OCC1CC1>>O=C(N[C@H]1CCCC[C@@H]1n1cnc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2Cc2cc(F)cc(F)c2)c1-c1ccccc1)OCC1CC1,CN(C)c1ccncc1,C1CCOC1,,[Na+].[OH-],,val
US20040180883A1,CC(C)(C)[Si](C)(C)Cl.OCC=C1c2ccsc2CCC1(F)F>>CC(C)(C)[Si](C)(C)OCC=C1c2ccsc2CCC1(F)F,,CN(C)C=O,,O,c1c[nH]cn1,val
US20090149456A1,CN(C)C1Cc2ccc(N)cc2C1.O=C(Cc1cccs1)Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3cccc(-c4cnco4)c3)n2)c1>>CN(C)C1Cc2ccc(Nc3nccc(-c4c(-c5cccc(NC(=O)Cc6cccs6)c5)nn5ccccc45)n3)cc2C1,,CC(C)O,,CCOCC,Cl,val
US20120046267A1,COS(=O)(=O)OC.Oc1cc2c(Br)csc2cn1>>COc1cc2c(Br)csc2cn1,,CN(C)C=O,,[H-].[Na+],,val
US20090156612A1,CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)C[C@H]1CCO>>CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)C[C@H]1CC=O,,CS(C)=O,,CCN(CC)CC,,val
US05292739,CCOC(=O)c1cnn(CCCCN2CCN(c3ncccn3)CC2)c1>>O=C(O)c1cnn(CCCCN2CCN(c3ncccn3)CC2)c1,,Cl,,N,,val
US20060030612A1,Clc1ccc(CBr)c(Cl)c1.Fc1cc(F)c(Cn2nc3c(C(F)(F)F)cccc3c2-c2ccc3[nH]ccc3c2)c(F)c1>>Fc1cc(F)c(Cn2nc3c(C(F)(F)F)cccc3c2-c2ccc3c(ccn3Cc3ccc(Cl)cc3Cl)c2)c(F)c1,,CN(C)C=O,,[H-].[Na+],,val
US20100286164A1,C=CC=O.CC(C)NCc1ccccc1>>CC(C)N(CCC=O)Cc1ccccc1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20160214997A1,CC(C)(C)OC(=O)N1CCC(Cc2nc3c4ccc5c(c4nc(N)n3n2)OC(F)(F)O5)C1>>Nc1nc2c3c(ccc2c2nc(CC4CCNC4)nn12)OC(F)(F)O3,,C1COCCO1,,Cl,ClCCl,val
US20140323485A1,Nc1cc(C(F)(F)F)n[nH]1.Nc1nc(C(F)(F)F)c(Br)nc1C(=O)O>>Nc1nc(C(F)(F)F)c(Br)nc1C(=O)Nc1cc(C(F)(F)F)n[nH]1,,CN1CCCC1=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130102776A1,COc1ccc2c(c1C#CC1CCN(C(=O)OC(C)(C)C)CC1)O/C(=C\c1n[nH]c3ccccc13)C2=O>>COc1ccc2c(c1C#CC1CCNCC1)O/C(=C\c1n[nH]c3ccccc13)C2=O,,C1COCCO1,ClCCl,Cl,,val
US20040204398A1,C1CNCCN1.CC(C)(C)N1CC[C@@H](C(=O)O)[C@@H](c2ccc(F)cc2F)C1.CN1CCOCC1.ClCCCl.ClCCl.On1nnc2ccccc21>>CCN(CC)CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CCN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1,,ClCCl,,Cl,,val
US20090069303A1,CC(=O)OCc1cc([N+](=O)[O-])ccn1>>O=[N+]([O-])c1ccnc(CO)c1,,CO,,[Na+].[OH-],,val
US20150376233A1,C=CCCCC[C@@H](O)COC.Cc1ccc(S(=O)(=O)Cl)cc1>>C=CCCCC[C@H](COC)OS(=O)(=O)c1ccc(C)cc1,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US04595535,Cc1nc2n(n1)C(N1CCN(C)CC1)=Nc1ccccc1C2.O=C(O)/C=C\C(=O)O>>Cc1nc2n(n1)C(N1CCN(C)CC1)=Nc1ccccc1C2.O=C(O)/C=C\C(=O)O,,CC(C)O,,,,val
US06110961,CC(C)I.O=S1(=O)c2ccccc2Oc2cc(O)ccc21>>CC(C)Oc1ccc2c(c1)Oc1ccccc1S2(=O)=O,,CCCCCC,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US05547980,CC1=C(Cl)c2ccc(Cl)cc2S1(=O)=O.CCNCC>>CCN(CC)CC1=Cc2ccc(Cl)cc2S1(=O)=O,,CO,,,,val
US20070105836A1,CC(=O)N1CCNCC1.CC(C)(C)OC(=O)N1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1>>CC(=O)N1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1,,C1COCCO1,ClCCl,CCN(CC)CC,,val
US20130190338A1,N#Cc1ccc2ncsc2c1>>N#Cc1ccc(N)c(S)c1,,CCO,,NN,O,val
US05847122,COc1ccc([C@H](Sc2ccccc2N)[C@@H](O)C(=O)Nc2ccccc2)cc1>>COc1ccc([C@@H]2Sc3ccccc3NC(=O)[C@@H]2O)cc1,,Clc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US05262412,CCC(=O)Br.CCCCc1nn(-c2cc(N)ccc2Cl)c(C#N)c1Cc1ccc(Br)cc1F>>CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(C#N)c1Cc1ccc(Br)cc1F,CN(C)c1ccncc1,,,,,val
US04098888,CCON=C(C(=O)OCC)c1csc(NC(=O)OCC(Cl)(Cl)Cl)n1.Cl>>CCOC(=O)C(N)c1csc(NC(=O)OCC(Cl)(Cl)Cl)n1.Cl,[Pd],CCO,Cl,[H][H],,val
US06649768B1,Br.BrBr.CC(=O)c1cccnc1>>Br.O=C(c1cccnc1)C(Br)Br,,O,,,,val
US20100249126A1,CS(N)(=O)=O.Nc1ccc(-c2cc(-c3cccnc3F)nc(N3CCOCC3)n2)cn1>>CS(=O)(=O)Nc1ncccc1-c1cc(-c2ccc(N)nc2)nc(N2CCOCC2)n1,,CN1CCCC1=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130090351A1,COC(=O)N[C@H](C(=O)N1C[C@@H](C)C[C@H]1c1nc(I)c[nH]1)C(C)C.COC(=O)N[C@H](C(=O)N1C[C@@H](C)C[C@H]1c1nc2cc(I)ccc2[nH]1)C(C)C.OB(O)c1ccc(-c2ccc(B(O)O)cc2)cc1>>COC(=O)N[C@H](C(=O)N1C[C@@H](C)C[C@H]1c1nc(-c2ccc(-c3ccc(-c4ccc5[nH]c([C@@H]6C[C@H](C)CN6C(=O)[C@@H](NC(=O)OC)C(C)C)nc5c4)cc3)cc2)c[nH]1)C(C)C,,CC(C)O,,ClCCl,O=C([O-])O.[Na+],val
US20150105366A1,COc1nc2ccc(C(O)c3ccc(C)nc3C)cc2c(Cl)c1Cc1ccc(F)cc1>>COc1nc2ccc(C(=O)c3ccc(C)nc3C)cc2c(Cl)c1Cc1ccc(F)cc1,O=[Mn]=O,C1COCCO1,,N#N,,val
US20140088101A1,COC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2C)c1O.O=C1CCC(=O)N1Br>>COC(=O)c1nc(Br)c2c(cc(-c3ccccc3)c(=O)n2C)c1O,,ClCCl,,,,val
US05952355,COc1cc2[nH]cc(C=O)c2cc1OCc1ccccc1>>COc1cc2[nH]cc(C=O)c2cc1O,[Pd],CCOC(C)=O,,CO,,val
US04695639,CC(C)(C)OC(=O)CBr.CS(=O)(=O)CCOC(=O)/C(=N\O)c1csc(N)n1>>CC(C)(C)OC(=O)CO/N=C(\C(=O)O)c1csc(N)n1,,CC(C)=O,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US20090181928A1,CC(C)(C)[Si](C)(C)Oc1ccc(N2CC(=O)N(CC[Si](C)(C)C)S2(=O)=O)c(OCc2ccccc2)c1>>C[Si](C)(C)CCN1C(=O)CN(c2ccc(O)cc2OCc2ccccc2)S1(=O)=O,,C1CCOC1,C1COCCO1,Cl,,val
US20100261755A1,COC(=O)C1CCNC(c2ccc(F)c(F)c2)C1.COC(=O)Cl>>COC(=O)C1CCN(C(=O)OC)C(c2ccc(F)c(F)c2)C1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20130040984A1,CC(C)(C)C(=O)Nc1cc(Cl)nc(Cl)c1.CN(C)/C=C/C=O>>Clc1cc2ncccc2c(Cl)n1,,C1CCCCC1,C1CCOC1,CCOCC,[Li]CCCC,val
US20120138914A1,CCOc1ccc2ccccc2c1B(O)O.Fc1ccc(Br)cc1I>>CCOc1ccc2ccccc2c1-c1cc(Br)ccc1F,,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20090176786A1,CI.Cc1cc(SC(F)(F)C(F)(F)F)ccc1N(C)C(=O)NC(=O)c1c(F)cccc1F>>Cc1cc(SC(F)(F)C(F)(F)F)ccc1N(C)C(=O)N(C)C(=O)c1c(F)cccc1F,,CN1CCCC1=O,O,[H-].[Na+],[Cl-].[NH4+],val
US20050234125A1,CC(=O)COC1CCCCO1.N.[C-]#N>>CC(N)(C#N)COC1CCCCO1,,N,,[Cl-].[NH4+],,val
US20110112065A1,CCCNC.CS(=O)(=O)c1cc(F)c2c(c1)OC(CBr)OC2>>CCCN(C)CC1OCc2c(F)cc(S(C)(=O)=O)cc2O1,,CCO,,,,val
US20060247320A1,[N-]=[N+]=NCC(=O)c1ccccn1>>[N-]=[N+]=NC[C@H](O)c1ccccn1,,Cc1ccccc1,,CSC,,val
US20120022060A1,O=C(Cl)c1cccc(Cl)c1.c1ccc(Nc2ccnc3[nH]c4c(c23)CNCC4)cc1>>O=C(c1cccc(Cl)c1)N1CCc2[nH]c3nccc(Nc4ccccc4)c3c2C1,,ClCCCl,,CCN(CC)CC,,val
US20050065151A1,C1COCCN1.COc1cnc(N2CCOCC2)c2sc(N)nc12.O=C(Cl)c1ccc(CCl)cc1>>COc1cnc(N2CCOCC2)c2sc(NC(=O)c3ccc(CN4CCOCC4)cc3)nc12,,C1CCOC1,ClCCCl,CCN(C(C)C)C(C)C,,val
US04337341,COc1cccc(Br)c1.[Li]CCCC>>[Li]c1cccc(OC)c1,,CCCCCC,,,,val
US20110263658A1,CC(=O)NCc1ccccc1-c1ccc(C(CNC(=O)OC(C)(C)C)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c(C)c1.Cl>>CC(=O)NCc1ccccc1-c1ccc(C(CN)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c(C)c1.Cl,,CCOC(C)=O,CCOCC,,,val
US20090029905A1,Cc1cnc(NC(=O)c2cc(Oc3ncc(C(=O)N4CCC4)cc3Cl)cc(O[C@@H](C)CO[Si](C)(C)C(C)(C)C)c2)cn1>>Cc1cnc(NC(=O)c2cc(Oc3ncc(C(=O)N4CCC4)cc3Cl)cc(O[C@@H](C)CO)c2)cn1,,CO,,Cl,,val
US04739066,CCOC(=O)C(O)CCCCC1CCN(C(=O)OCc2ccccc2)CC1>>O=C(O)C(O)CCCCC1CCN(C(=O)OCc2ccccc2)CC1,,CO,O,[Na+].[OH-],,val
US20080261990A1,Cn1ccnc1CN(Cc1ccc(SC(C)(C)C(=O)OC(C)(C)C)cc1)c1cc(Nc2ccc(C(F)(F)F)cc2)ncn1>>Cn1ccnc1CN(Cc1ccc(SC(C)(C)C(=O)O)cc1)c1cc(Nc2ccc(C(F)(F)F)cc2)ncn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030130277A1,Cc1ccc2c(c1)c(=O)c1c(cnn1C)n2CC#N.O>>Cc1ccc2c(c1)c(=O)c1c(cnn1C)n2CC(N)=O,,CC(C)(C)O,,[K+].[OH-],,val
US20020156081A1,CN(C)c1ccc(C(=O)Cl)cc1.COc1cc(-c2nn(C3CCN(C4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1N>>COc1cc(-c2nn(C3CCN(C4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)c1ccc(N(C)C)cc1,,ClCCl,c1ccncc1,,,val
US20030149038A1,BrCc1ccccc1.O=[N+]([O-])c1ccccc1B(O)O>>O=[N+]([O-])c1ccccc1Cc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US04176116,CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N.Cc1ccc(S(=O)(=O)Cl)cc1>>CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NS(=O)(=O)c1ccc(C)cc1,,c1ccncc1,,Br,,val
US04024276,CCCCCC(=O)Cl.Oc1ccccc1>>CCCCCC(=O)Oc1ccccc1,,c1ccncc1,,,,val
US20130184253A1,CI.CN(C)[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1O>>CO[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1N(C)C,,C1CCOC1,,[H-].[Na+],,val
US20060079526A1,CSC(=N)Nc1ccc(Cl)c(C(F)(F)F)c1.NNC(=O)c1ccc(O)cc1>>Oc1ccc(-c2nnc(Nc3ccc(Cl)c(C(F)(F)F)c3)[nH]2)cc1,,c1ccncc1,,I,,val
US20110028450A1,C#CCN(CCO[Si](C)(C)C(C)(C)C)C(=O)OC(C)(C)C>>C#CCN(CCO)C(=O)OC(C)(C)C,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20130217664A1,CCI.CCc1ccccc1Nc1cc2c(cn1)ncn2C>>CCc1ccccc1N(CC)c1cc2c(cn1)ncn2C,,CN(C)C=O,,[H-].[Na+],,val
US20070254892A1,FCC1CO1.O=[N+]([O-])c1ccc(N2CCNCC2)cc1>>O=[N+]([O-])c1ccc(N2CCN(CC(O)CF)CC2)cc1,,CCO,,,,val
US04235902,CC(C)CON=O.CCC1COCC(=O)N1C>>CCC1COC(=NO)C(=O)N1C,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20050004187A1,CC(C)(C)OC(=O)CBr.CC(C)(C)[Si](C)(C)Oc1ccc2c(Cl)c[nH]c2c1>>CC(C)(C)OC(=O)Cn1cc(Cl)c2ccc(O[Si](C)(C)C(C)(C)C)cc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080242685A1,CC(C)(C)OC(=O)N1CCC(c2c[nH]c3c(C(N)=O)nc(-c4ccccc4)cc23)CC1>>NC(=O)c1nc(-c2ccccc2)cc2c(C3CCNCC3)c[nH]c12,,CO,,Cl,,val
US20120258952A1,C=O.CCc1nn(Cc2cccc(OC[C@H]3NCC[C@@H]3O)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12>>CCc1nn(Cc2cccc(OC[C@@H]3[C@@H](O)CCN3C)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120283297A1,CCOC(=O)CCCn1ncc2c(C)c(-c3noc(-c4cnc(OC(C)C)c(Cl)c4)n3)ccc21>>Cc1c(-c2noc(-c3cnc(OC(C)C)c(Cl)c3)n2)ccc2c1cnn2CCCC(=O)O,,C1CCOC1,,Cl,[Na+].[OH-],val
US20150361097A1,BrCCCCCBr.N#CCc1ccc(Cl)nc1>>N#CC1(c2ccc(Cl)nc2)CCCCC1,,C1CCOC1,CS(C)=O,O,[H-].[Na+],val
US07226931B2,CCOC(=O)c1cc(C2CC2)c2c(C)c(N3CCC(C4(N(C)C5CCN(C(=O)OC(C)(C)C)CC5)CC4)C3)c(F)cn2c1=O>>Cc1c(N2CCC(C3(N(C)C4CCN(C(=O)OC(C)(C)C)CC4)CC3)C2)c(F)cn2c(=O)c(C(=O)O)cc(C3CC3)c12,,CCO,O,[Li+].[OH-],,val
US06037498,C=CCN([C@@H](C)c1ccccc1)[C@H](CC(=O)OC(C)(C)C)c1ccccc1.CI>>C=CCN([C@@H](C)c1ccccc1)[C@@H](c1ccccc1)[C@H](C)C(=O)OC(C)(C)C,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20140051679A1,CN1CCC(Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2Cl)CC1.O=C(NC(c1ccccn1)C1CC1)c1ccc2[nH]nc(I)c2c1>>CN1CCC(Oc2ccc(-c3n[nH]c4ccc(C(=O)NC(c5ccccn5)C5CC5)cc34)cc2Cl)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US05324725,COc1cc2c3c(c1)c(CCN1CCN(c4cc(C)ccn4)CC1)c(C)n3CCC2>>Cc1ccnc(N2CCN(CCc3c(C)n4c5c(cc(O)cc35)CCC4)CC2)c1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US04282212,N#CC1CN1.O=C=NC(=O)C1CCCCC1>>N#CC1CN1C(=O)NC(=O)C1CCCCC1,,Cc1ccccc1,,,,val
US04616014,CC(=O)OC(C)=O.Cc1nc(NN)nnc1-c1ccccc1>>CC(=O)NNc1nnc(-c2ccccc2)c(C)n1,,ClCCl,,,,val
US20070167488A1,Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1.O=C1CCC(=O)N1Br>>Cc1[nH]c(C=C2C(=O)Nc3ccccc32)c(C)c1Br,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20040248950A1,COc1ccc(C(N)=S)cc1.O=C(CBr)c1ccccc1>>COc1ccc(-c2nc(-c3ccccc3)cs2)cc1,,CCO,,,,val
US20080153837A1,NO.O=C1c2ccccc2-c2c1cccc2-c1nc2ccncc2[nH]1>>ON=C1c2ccccc2-c2c1cccc2-c1nc2ccncc2[nH]1,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20120238574A1,CN(C(=O)OC(C)(C)C)C1CCN(Cc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)CC1>>CNC1CCN(Cc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150259343A1,C=O.NCCN1CCC(C2CCOCC2)c2ccccc21>>c1cc2c3c(c1)C(C1CCOCC1)CCN3CCNC2,,CCO,,O=C(O)C(F)(F)F,,val
US20050131042A1,Cc1nc(CN2CCN([C@H](C(=O)N[C@@H](Cc3ccccc3)[C@H](O)CN(CC3CCCN3C(=O)OC(C)(C)C)S(=O)(=O)c3ccc(C=NO)cc3)C(C)C)C2=O)cs1>>Cc1nc(CN2CCN([C@H](C(=O)N[C@@H](Cc3ccccc3)[C@H](O)CN(CC3CCCN3)S(=O)(=O)c3ccc(/C=N/O)cc3)C(C)C)C2=O)cs1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20060281789A1,Cc1ccc(S(=O)(=O)C#N)cc1.O=Cc1ccc(OCCN2CCOCC2)c(Br)c1>>N#Cc1cc(C=O)ccc1OCCN1CCOCC1,,C1CCOC1,,[Li]CCCC,,val
US20010007764A1,COC(=O)[C@@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OCc1ccccc1.Cl>>COC(=O)[C@H](N)Cc1ccc(OC(C)(C)C)cc1.Cl,[Pd],CO,,,,val
US20110136780A1,CC(C)[C@H](C(=O)O)N1Cc2c(Cl)cnc3[nH]cc(c23)C1=O.N#CC1CCNCC1>>CC(C)[C@H](C(=O)N1CCC(C#N)CC1)N1Cc2c(Cl)cnc3[nH]cc(c23)C1=O,,C1CCOC1,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20050143422A1,CCC(=O)c1ccccc1OCC(=O)OC>>CCc1c(C(=O)OC)oc2ccccc12,,CO,O,Cl,C[O-].[Na+],val
US20090118501A1,CCOC(=O)CSc1cnc(NC(=O)N(C2CCCCC2)[C@@H]2CC[C@@H](COc3ccccc3)CC2)s1>>O=C(O)CSc1cnc(NC(=O)N(C2CCCCC2)[C@@H]2CC[C@@H](COc3ccccc3)CC2)s1,,C1CCOC1,,Cl,[Na+].[OH-],val
US04839379,C=CCN1C(=O)C2CC2(c2ccc(NC(C)=O)cc2)C1=O>>C=CCN1C(=O)C2CC2(c2ccc(N)cc2)C1=O,,O,,Cl,[Na+].[OH-],val
US20090306071A1,CC(C)(C)ON=O.O=C(Cc1ccnc(F)c1)c1ccc(Br)cc1>>O=C(C(=NO)c1ccnc(F)c1)c1ccc(Br)cc1,,CCO,,Cl,,val
US20160039838A1,Nc1ccc2c(cnn2Cc2cccc(F)c2)c1.O=[N+]([O-])c1ccc2ncnc(Cl)c2c1>>O=[N+]([O-])c1ccc2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c2c1,,CC(C)O,,,,val
US20160002188A1,CCOC(=S)S[K].Nc1ccc(F)cc1O>>Fc1ccc2[nH]c(=S)oc2c1,,CCO,,,,val
US20090298815A1,CC(C)(C)OC(=O)N1CCC(c2nc(-c3cccc(N)c3F)c(-c3ccnc(Cl)n3)s2)CC1.O=S(=O)(Cl)c1ccoc1>>CC(C)(C)OC(=O)N1CCC(c2nc(-c3cccc(NS(=O)(=O)c4ccoc4)c3F)c(-c3ccnc(Cl)n3)s2)CC1,,c1ccncc1,,,,val
US06319915B1,Cc1ccccc1C1CCC(=O)C(c2ccccc2)C1.NO>>Cc1ccccc1C1CCC(=NO)C(c2ccccc2)C1,,CO,ClCCl,CCN(CC)CC,Cl,val
US04705786,CC(=O)Cc1nc(CCl)no1.COC(=O)/C=C(/C)N.O=Cc1cccc([N+](=O)[O-])c1>>COC(=O)C1=C(C)NC(C)=C(c2nc(CCl)no2)C1c1cccc([N+](=O)[O-])c1,,CC(C)O,,,,val
US20100252433A1,CCOC(=O)/C=C/c1c[nH]c(-c2cccs2)c1>>CCOC(=O)CCc1c[nH]c(-c2cccs2)c1,[Pd],CCO,,[H][H],,val
US20080176862A1,CN1C(=O)C(c2cccc(O)c2)(c2ccc(F)c(Br)c2)NC1=S.CS(=O)(=O)Cl>>CN1C(=O)C(c2cccc(OS(C)(=O)=O)c2)(c2ccc(F)c(Br)c2)NC1=S,,ClCCl,,CCN(CC)CC,,val
US20150045359A1,CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc3[nH]c4ncccc4c3c2)C1.Cl>>Cl.c1cnc2[nH]c3ccc([C@H]4CNCCO4)cc3c2c1,,C1COCCO1,,CCOCC,,val
US20100173944A1,CCOc1ccnc(COC(C)=O)c1C>>CCOc1ccnc(CO)c1C,,Cc1ccccc1,,[Na+].[OH-],,val
US20110224188A1,CC(C)(C)OC(=O)N1CC[C@@H](c2nsc(=O)[nH]2)C1>>O=c1[nH]c([C@@H]2CCNC2)ns1,,CO,,C1COCCO1,Cl,val
US20150011526A1,O=C1CCCCN1c1ccccc1CCO>>O=CCc1ccccc1N1CCCCC1=O,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20030216428A1,C=COCC.CC(C)(C=O)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.Nc1ccc([N+](=O)[O-])cc1>>CCOC1CC(C(C)(C)CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)Nc2ccc([N+](=O)[O-])cc21,,CC#N,,O=C(O)C(F)(F)F,,val
US05071859,BrCCBr.Cc1ccccc1C(C=O)c1ccc(F)cc1C>>Cc1ccccc1C(=COCCBr)c1ccc(F)cc1C,,C1CCOC1,C1CCOC1,[H-].[Na+],,val
US04888345,Cc1ccc(C(=O)C=CN(C)C)cc1.NC(=O)c1[nH]cnc1N>>Cc1ccc(-c2ccnc3c(C(N)=O)ncn23)cc1,,CC(=O)O,,Cl,O=C([O-])O.[Na+],val
US20110207773A1,Nc1ccc(F)cn1.O=C(O)c1cc(-c2ccc(Cl)c(Cl)c2)nc2ccccc12>>O=C(Nc1ccc(F)cn1)c1cc(-c2ccc(Cl)c(Cl)c2)nc2ccccc12,,ClCCl,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US20060235222A1,CI.CS(=O)(=O)Nc1cccc2cc[nH]c12>>CN(c1cccc2cc[nH]c12)S(C)(=O)=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040029902A1,CCOC(=O)c1nc(Nc2cccc(O)c2)nc(Nc2cccc(O)c2)c1[N+](=O)[O-]>>CCOC(=O)c1nc(Nc2cccc(O)c2)nc(Nc2cccc(O)c2)c1N,[Pd],CCO,,,,val
US20090143353A1,CC(C)(C)C(=O)Cl.CN(C)[C@H]1CCN(c2cc(N)c(C#N)cc2-c2ccccc2)C1>>CN(C)[C@H]1CCN(c2cc(NC(=O)C(C)(C)C)c(C#N)cc2-c2ccccc2)C1,,c1ccncc1,,CCOC(C)=O,[Na+].[OH-],val
US04904658,CN(C)C=CC(=O)c1cccc([N+](=O)[O-])c1.NC(=O)c1[nH]cnc1N>>NC(=O)c1ncn2c(-c3cccc([N+](=O)[O-])c3)ccnc12,,CC(=O)O,,Cl,,val
US20100105941A1,CCC(C)=O.CO.Cc1ccc(N=C=O)cc1N=C=O.Nc1ccc(S(=O)(=O)c2ccc(N)cc2)cc1>>CCOC(N)=O.NC(N)=O,,CCC(C)=O,,,,val
US05877025,Nc1cccc(B(O)O)c1.O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N=C=S)cc21>>O=C(O)c1ccccc1-c1c2ccc(=O)cc-2oc2cc(O)ccc12.OBO,,CO,,CCN(CC)CC,,val
US20050176775A1,Cc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1Cc1ccc(C(N)=O)cc1>>Cc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1Cc1ccc(CN)cc1,,C1CCOC1,,B,CSC,val
US08394820B2,NC(=O)c1cc2cc(C(F)(F)F)ccc2n1Cc1cccc(F)c1.Nc1cc(Br)ccn1>>Nc1cc(NC(=O)c2cc3cc(C(F)(F)F)ccc3n2Cc2cccc(F)c2)ccn1,I[Cu]I,C1COCCO1,O,N[C@@H]1CCCC[C@H]1N,O=C([O-])[O-].[K+].[K+],val
US06288082B1,COc1cc2ncc(C#N)c(Cl)c2cc1OC.Nc1ccc2nc[nH]c2c1>>COc1cc2ncc(C#N)c(Nc3ccc4[nH]cnc4c3)c2cc1OC,,CCOCCO,,Cl,c1ccncc1,val
US20090302752A1,Cc1ccccc1B(O)O.O=[N+]([O-])c1cc(Br)ccc1-c1ccccc1>>Cc1ccccc1-c1ccc(-c2ccccc2)cc1[N+](=O)[O-],c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,O,O=C([O-])[O-].[K+].[K+],,val
US20100113458A1,CCN(CC)c1ccc(Nc2cc(N(Cc3ccc(OC)cc3)C3CC3)c3ncc(C#N)n3n2)cc1>>CCN(CC)c1ccc(Nc2cc(NC3CC3)c3ncc(C#N)n3n2)cc1,,ClCCl,,CO,O=C(O)C(F)(F)F,val
US04604388,CN1CC(CCCl)Oc2ncccc2C1=O.O=C1NC(=O)c2ccccc21>>CN1CC(CCN2C(=O)c3ccccc3C2=O)Oc2ncccc2C1=O,,CN(C)C=O,,[K],,val
US20090137499A1,COc1ccc(Cc2ccc(COC(C)=O)cc2O[C@@H]2O[C@H]([C@H](C)OC(=O)c3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@H](OC(=O)c3ccccc3)[C@H]2OC(=O)c2ccccc2)c(F)c1>>COc1ccc(Cc2ccc(CO)cc2O[C@@H]2O[C@H]([C@@H](C)O)[C@@H](O)[C@H](O)[C@H]2O)c(F)c1,,C1CCOC1,CO,O=C([O-])[O-].[K+].[K+],,val
US06417397B1,CNC(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>COC(=O)[C@H](Cc1ccccc1)NC(=O)C(C)(C)N(C)C(=O)c1ccc([N+](=O)[O-])cc1,,ClCCl,,Cl,,val
US04954518,CS(=O)(=O)Nc1cc2occ(NC(=O)CCCCl)c(=O)c2cc1Oc1ccccc1>>CS(=O)(=O)Nc1cc2occ(N3CCCC3=O)c(=O)c2cc1Oc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US04014872,O=C(Cc1ccccc1)N[C@@H]1C(=O)N2C[C@H](O)CS[C@H]12>>O=C1CS[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2C1,,CS(C)=O,,CC(=O)OC(C)=O,,val
US20120101079A1,CNC1CCCC(OC)C1.Cc1cc(Cl)nc(Cl)c1C(=O)NCc1cccc(F)c1>>COC1CCCC(N(C)c2cc(C)c(C(=O)NCc3cccc(F)c3)c(Cl)n2)C1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080194546A1,CC(C)Oc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1C#N.O=S(=O)(O)O>>C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc(O)c(C(N)=O)c3)nc2n1,,O,,[Na+].[OH-],,val
US20140274703A1,CC(C)OB1OC(C)(C)C(C)(C)O1.Fc1c(Cl)cccc1Cl>>CC1(C)OB(c2ccc(Cl)c(F)c2Cl)OC1(C)C,,C1CCOC1,O,Cl,[Li]CCCC,val
US05334596,CC(C)(C)OC(=O)N1CCC(CCN2CCc3sc(Br)cc3C2=O)CC1.O=C1CCCCO1>>CC(C)(C)OC(=O)N1CCC(CCN2CCc3sc(C(=O)CCCCO)cc3C2=O)CC1,,C1CCOC1,,[Li]CCCC,,val
US20150175619A1,BrCC1CC1.CC(C)(C)[Si](OC1CC2C(C1)C2c1cc(-c2cnc(N)c(OC(F)(F)F)c2)n[nH]1)(c1ccccc1)c1ccccc1>>CC(C)(C)[Si](OC1CC2C(C1)C2c1cc(-c2cnc(N)c(OC(F)(F)F)c2)nn1CC1CC1)(c1ccccc1)c1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090130076A1,CC(=O)O.N#Cc1cc(Br)c2nc(N)sc2c1.O=S(=O)(O)O>>Nc1nc2c(Br)cc(C(=O)O)cc2s1,,CC(=O)O,,O,,val
US04746352,CC(C)OC(=O)c1cc(-n2c(=O)[nH]c3c(c2=O)CCC3)c(Br)cc1Br.COS(=O)(=O)OC>>CC(C)OC(=O)c1cc(-n2c(=O)c3c(n(C)c2=O)CCC3)c(Br)cc1Br,,CC(C)O,,[Na],,val
US20070112011A1,C#CC(=O)O.Fc1ccc(I)c(F)c1>>O=C(O)C#Cc1ccc(F)cc1F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,CC(C)NC(C)C,,val
US05665718,CCCNCCC.CN1Cc2c(-c3noc(CCl)n3)ncn2-c2ccc(F)c(Cl)c2C1=O>>CN1Cc2c(-c3noc(CN4CCCCC4)n3)ncn2-c2ccc(F)c(Cl)c2C1=O,,CN(C)C=O,,,,val
US20140275027A1,COc1ccc(F)cc1-c1ccnc2c1c(C#N)cn2COCC[Si](C)(C)C.II>>COc1ccc(F)cc1-c1ccnc2c1c(C#N)c(I)n2COCC[Si](C)(C)C,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20090306133A1,CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CNC(=O)c2cc(-c3ccccc3)nc3ccccc23)CC1.CI>>CN(C[C@@H]1CC[C@@H](CNC(=O)OC(C)(C)C)CC1)C(=O)c1cc(-c2ccccc2)nc2ccccc12,,CN(C)C=O,CS(C)=O,[H-].[Na+],O=C([O-])[O-].[K+].[K+],val
US05354866,CC(C)(C)[Si](C)(C)OCC(=CC(=O)O)CO>>CC(C)(C)[Si](C)(C)OCC(=CCO)CO,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20030187023A1,CN(C(=O)C(C)(C)CCl)C1CCN(C(=O)OC(C)(C)C)CC1.Sc1ccc2cc(Cl)ccc2c1>>CN(C(=O)C(C)(C)CSc1ccc2cc(Cl)ccc2c1)C1CCN(C(=O)OC(C)(C)C)CC1,,CO,,C[O-].[Na+],,val
US20110034450A1,CCOC(=O)C(c1ccc(CBr)cc1)C(C)C(F)(F)F.O=C1NCc2ccccc21>>CCOC(=O)C(c1ccc(CN2Cc3ccccc3C2=O)cc1)C(C)C(F)(F)F,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20150315198A1,O=S(Cl)Cl.O=c1c2cc(CO)ccc2nc2n1CCC2>>O=c1c2cc(CCl)ccc2nc2n1CCC2,,CN(C)C=O,,ClCCl,,val
US20080081810A1,CCOC(=O)c1cc2ccc(OC)cc2[nH]1>>CCOC(=O)C1Cc2ccc(OC)cc2N1,,O=C(O)C(F)(F)F,,[BH3-]C#N.[Na+],,val
US20050222148A1,CN.Cc1ccc(S(=O)(=O)OC[C@@H](O)[C@H](c2ccccc2)n2c(=O)n(C(C)(C)C)c3ccccc32)cc1>>CNC[C@@H](O)[C@H](c1ccccc1)n1c(=O)n(C(C)(C)C)c2ccccc21,,CO,,,,val
US20110021537A1,CCCCOC(=O)NC1CCN(C(=O)CN)CC1.O=C(O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1>>CCCCOC(=O)NC1CCN(C(=O)CNC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)n(-c3ccccc3)n2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100113528A1,CCOC(=O)CCn1ncc2cc(C#N)ccc21.NO>>CCOC(=O)CCn1ncc2cc(C(=N)NO)ccc21,,CCO,,Cl,O=C([O-])O.[Na+],val
US20130267493A1,Brc1ccc(C2CCNC2)cc1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCC(c2ccc(Br)cc2)C1,,C1CCOC1,O,CCN(CC)CC,Cl,val
US20110263598A1,C[S+](C)(C)=O.C[Si](C)(C)CCOCn1nc(I)c2ccc(/C=C3/C(=O)Nc4ccccc43)cc21>>C[Si](C)(C)CCOCn1nc(I)c2ccc([C@@H]3C[C@@]34C(=O)Nc3ccccc34)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20070135467A1,CO[C@](C(=O)Cl)(c1ccccc1)C(F)(F)F.NC(Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1>>CO[C@](C(=O)N[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1)(c1ccccc1)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US20120264735A1,CI.COc1cnc(-c2cccc(Cc3nn(-c4cnn(C)c4)ccc3=O)c2)nc1>>COc1cnc(-c2cccc(C(C)c3nn(-c4cnn(C)c4)ccc3=O)c2)nc1,,C1CCOC1,CN(C)C=O,[H-].[Na+],[Cl-].[NH4+],val
US20030022883A1,CC(C)N(C(=O)c1ccccc1-c1cnccc1N)C(C)C>>O=c1[nH]c2ccncc2c2ccccc12,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20100029633A1,COCCOc1ccn2c(-c3ccc4cccc(OC[C@H]5CCCN5C(=O)OC(C)(C)C)c4n3)cnc2c1>>COCCOc1ccn2c(-c3ccc4cccc(OC[C@H]5CCCN5)c4n3)cnc2c1,,ClC(Cl)Cl,,C1COCCO1,Cl,val
US20160237067A1,CCN(CC)CCNC(=O)c1cccc(-c2ccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CNC(=O)OC(C)(C)C)CC3)C(=O)Nc3ccc(-c4nn[nH]n4)cc3)cc2)c1.Cl>>CCN(CC)CCNC(=O)c1cccc(-c2ccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CN)CC3)C(=O)Nc3ccc(-c4nn[nH]n4)cc3)cc2)c1.Cl,,C1COCCO1,,O=C(O)C(F)(F)F,,val
US20100298316A1,N#Cc1ccc2oc(N3CCN(C4CC4)CC3)nc2c1>>c1ccc2oc(N3CCN(C4CC4)CC3)nc2c1,[Ni],C1CCOC1,CO,[NH4+].[OH-],,val
US06908940B2,BrCc1ccccc1.C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)CCc1ccc(F)cc1O>>C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)CCc1ccc(F)cc1OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04556630,CC(=O)OC(C)=O.CC(C)(C)CC(C)(C)c1ccc(O)c(N)c1>>CC(=O)Nc1cc(C(C)(C)CC(C)(C)C)ccc1O,,CC#N,,,,val
US04678781,CC(=O)NCCCl.CSc1ccncc1.O=C(OO)c1cccc(Cl)c1>>CC(=O)NCC[n+]1ccc(S(C)=O)cc1.[Cl-],,ClCCl,O=C(O)C(F)(F)F,,,val
US05708018,CCCN(CCC)C1Cc2cc(OC)c(C(=O)OC)cc2C1>>CCCN(CCC)C1Cc2cc(CO)c(OC)cc2C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030176454A1,O=C(OO)c1cccc(Cl)c1.c1cc(-c2ccsc2)c2ccncc2c1>>[O-][n+]1ccc2c(-c3ccsc3)cccc2c1,,ClCCl,,CCOC(C)=O,,val
US20140256729A1,CC(C)(C)OC(=O)NC1CCC(=O)CC1.N[C@@H]1C[C@H]1c1ccc(OCc2cccc(Br)c2)cc1>>CC(C)(C)OC(=O)NC1CCC(N[C@@H]2C[C@H]2c2ccc(OCc3cccc(Br)c3)cc2)CC1,,ClCCCl,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US06162808,CCOC(=O)c1csc(Cn2cc(C3c4ccccc4C=Cc4ccccc43)c(=O)[nH]c2=O)n1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)c1csc(Cn2cc(C3c4ccccc4C=Cc4ccccc43)c(=S)[nH]c2=O)n1,,C1COCCO1,CCOC(C)=O,,,val
US20060079533A1,CC(C)(C)OC(=O)N1CCC(c2ccc(F)cc2)C(/C=C/c2ccc3ccccc3c2)C1>>Fc1ccc(C2CCNCC2/C=C/c2ccc3ccccc3c2)cc1,,CO,,Cl,,val
US08906135B1,C[n+]1nn(-c2ccncc2)cc1-c1ccccc1.O=S(=O)([N-]S(=O)(=O)C(F)(F)F)C(F)(F)F>>C[n+]1nn(-c2ccncc2)cc1-c1ccccc1.O=S(=O)([N-]S(=O)(=O)C(F)(F)F)C(F)(F)F,,CC#N,,[I-].[Li+],,val
US20110230457A1,CC(C)(C)OC(=O)NC1CCC(C=O)CC1.Nc1ccc(I)cc1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CNc2ccc(I)cc2)CC1,,CCOCC,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040106604A1,Cc1cccc(C(=O)Cc2ccc(F)cc2)n1.NN1C(=O)CC[C@@H]1COCc1ccccc1>>Cc1cccc(C(Cc2ccc(F)cc2)=NN2C(=O)CC[C@@H]2COCc2ccccc2)n1,,C1CCOC1,,CCOCC,FB(F)F,val
US20160038504A1,C[C@@H]1COCCN1.Clc1cc(Cl)c(Cl)nn1>>C[C@@H]1COCCN1c1cc(Cl)nnc1Cl,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,O,val
US20100041693A1,COC(=O)C(=O)Cl.Cc1cc2cc(C(O[SiH2]C(C)(C)C)(c3ccccc3)c3ccccc3)ccn2n1>>COC(=O)C(=O)c1c(C)nn2ccc(C(O[SiH2]C(C)(C)C)(c3ccccc3)c3ccccc3)cc12,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20090258891A1,C=CCCC(=O)O.CC(C)(C)OC(=O)NN>>C=CCCC(=O)NNC(=O)OC(C)(C)C,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US07169926B1,Cn1c(=O)c(N)c(N)c2ccccc21.O=C(Cl)C1CCN(C(=O)OCc2ccccc2)CC1>>Cn1c(=O)c2[nH]c(C3CCN(C(=O)OCc4ccccc4)CC3)nc2c2ccccc21,,ClCCl,,CCN(CC)CC,,val
US04831151,CCc1nccn1N=Cc1ccccc1.O=C(CBr)c1ccc(Cl)cc1>>CCc1n(CC(=O)c2ccc(Cl)cc2)cc[n+]1N=Cc1ccccc1.[Br-],,ClCCCl,,,,val
US20130338367A1,O=C(Nc1cnn(-c2cccnc2)c1)C(Br)CCCBr>>O=C1C(Br)CCCN1c1cnn(-c2cccnc2)c1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20150087639A1,CC(=O)C=C=O.CCCCCCN(CCCCCC)c1ccc(N)cc1F>>CCCCCCN(CCCCCC)c1ccc(NC(=O)CC(C)=O)cc1F,,Cc1ccccc1,,,,val
US20090324581A1,COC(=O)CCC(=O)N1CCCc2cc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)ccc21>>O=C(O)CCC(=O)N1CCCc2cc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)ccc21,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US05292760,CNC(Cc1ccccc1N)c1sccc1C.COC(OC)(OC)c1ccccc1>>Cc1ccsc1C1Cc2ccccc2N=C(c2ccccc2)N1C,,CC(=O)O,,,,val
US20090093525A1,CCOC(=O)[C@H]1[C@H](c2cccc(OC)c2)C1(C)C>>COc1cccc([C@H]2[C@H](C(=O)O)C2(C)C)c1,,O,,CCO,[Na+].[OH-],val
US20070155805A1,CCCCC(CCBr)c1sc2cc(C(F)(F)F)ccc2c1C.COC(=O)Cc1ccc(O)cc1>>CCCCC(CCOc1ccc(CC(=O)OC)cc1)c1sc2cc(C(F)(F)F)ccc2c1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080261969A1,CCOC(=O)c1[nH]ccc1N>>CCOC(=O)c1[nH]ccc1N,,ClCCl,,Cl,[Na+].[OH-],val
US20110071141A1,O=C1NC(=O)c2ccccc21.OC1CCc2cc(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)ccc21>>O=C1c2ccccc2C(=O)N1C1CCc2cc(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)ccc21,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130252944A1,COc1ccc(Cn2cc3c(n2)C(C(F)(F)F)OCC(Br)C3=O)cc1.Cc1ccnc(NC(N)=S)n1>>COc1ccc(Cn2cc3c(n2)C(C(F)(F)F)OCc2sc(Nc4nccc(C)n4)nc2-3)cc1,,CN(C)C=O,O,,,val
US20060178510A1,CC(C)(C)OC(=O)N1CCO[C@H](C(=O)c2cc(F)c(OCc3ccccc3)cc2F)C1>>CC(C)(C)OC(=O)N1CCO[C@H](C(O)c2cc(F)c(OCc3ccccc3)cc2F)C1,,CO,,[BH4-].[Na+],,val
US20120010271A1,O=C(OCC1c2ccccc2-c2ccccc21)ON1C(=O)CCC1=O.OC[C@@H]1CCCN1>>O=C(OCC1c2ccccc2-c2ccccc21)N1CCC[C@H]1CO,,C1CCOC1,O,,,val
US06340679B1,CC(C)(C)OC(=O)[C@H](Cc1ccc(OCCCC(=O)NC2=NCCCN2)cc1)NS(=O)(=O)c1ccccc1>>O=C(CCCOc1ccc(C[C@H](NS(=O)(=O)c2ccccc2)C(=O)O)cc1)NC1=NCCCN1,,O,O=C(O)C(F)(F)F,,,val
US20110046132A1,Cc1cccc(S)c1.Nc1cc(Cl)c(Cl)cc1[N+](=O)[O-]>>Cc1cccc(Sc2cc(N)c([N+](=O)[O-])cc2Cl)c1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100249068A1,CCCC(O)[C@H]1O[C@@H](n2ccc(NC(c3ccccc3)(c3ccccc3)c3ccc(OC)cc3)nc2=O)C(F)(F)[C@@H]1OC(c1ccccc1)(c1ccccc1)c1ccc(OC)cc1>>CCC[C@H](O)[C@H]1O[C@@H](n2ccc(N)nc2=O)C(F)(F)[C@@H]1O,,CC(=O)O,O,,,val
US05053414,CN(Cc1ccccc1)C(=O)CCC(=O)N1CCC[C@H]1C=O.OCCO>>CN(Cc1ccccc1)C(=O)CCC(=O)N1CCC[C@H]1C1OCCO1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20070232631A1,Nc1ccc(Sc2ncc(Br)cn2)cc1.O=C=NC(=O)c1ccccc1[N+](=O)[O-]>>O=C(NC(=O)c1ccccc1[N+](=O)[O-])Nc1ccc(Sc2ncc(Br)cn2)cc1,,C1COCCO1,O,,,val
US04933355,CCOC(=O)C(=O)c1csc(N)n1.CN=C=O>>CCOC(=O)C(=O)c1csc(NC(=O)NC)n1,,CCOC(C)=O,,,,val
US20040077669A1,CC#CCO.N#CCN(c1cc(Cl)ncn1)c1cccc(F)c1F>>CC#CCOc1cc(N(CC#N)c2cccc(F)c2F)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20100183513A1,Cc1ccc(-c2cnc(NC(=O)c3cnc(NCc4ccccc4)s3)s2)cc1>>Cc1ccc(-c2cnc(NCc3cnc(NCc4ccccc4)s3)s2)cc1,,C1CCOC1,,,,val
US20130029969A1,C1CCNC1.NC(=O)c1sc(Br)cc1N.O=C(Cl)C(Cl)c1ccccc1>>NC(=O)c1sc(Br)cc1NC(=O)C(c1ccccc1)N1CCCC1,,C1CCOC1,,CCN(CC)CC,,val
US04230714,Cc1ccc(O)c(CN(C)C)n1.c1c[nH]cn1>>Cc1ccc(O)c(Cn2ccnc2)n1,,Cc1ccccc1C,,,,val
US06248739B1,CCOC=C(C(=O)OCC)C(=O)OCC.c1cc(NC2CCOCC2)ccc1CN1CCOCC1>>CCOC(=O)C(=CN(c1ccc(CN2CCOCC2)cc1)C1CCOCC1)C(=O)OCC,,c1ccncc1,,,,val
US20030134859A1,CCCCC=O.Nc1ccc(-c2ccc(NC(=O)c3cc([N+](=O)[O-])ccc3Cl)cc2)cc1>>CCCCCNc1ccc(-c2ccc(NC(=O)c3cc([N+](=O)[O-])ccc3Cl)cc2)cc1,,CCO,CO,O=C([O-])O.[Na+],,val
US04927819,CC1C(=O)c2ccccc2C=Cc2ccccc21.[Li]C>>CC1c2ccccc2C=Cc2ccccc2C1(C)O,,CCOCC,,O,,val
US20100087667A1,CC(C)C(=O)OCCOC(=O)Oc1ccc(S(C)(=O)=O)cc1.NCC1(CC(=O)O)CCCCC1>>CC(C)C(=O)OCCOC(=O)NCC1(CC(=O)O)CCCCC1,,CC#N,CCOCC,O=C([O-])O.[K+],,val
US20160130259A1,CC(C)(C)OC(=O)n1c(-c2cc(Cl)cc(N)n2)cc2c(F)cccc21>>Nc1cc(Cl)cc(-c2cc3c(F)cccc3[nH]2)n1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20100298336A1,BrP(Br)Br.OCc1c(F)cncc1F>>Fc1cncc(F)c1CBr,,ClC(Cl)Cl,,O,,val
US04808584,CCOC(=O)c1c(SCC(=O)COC(C)=O)nc2c(F)c(F)c(F)cc2c1O>>O=C(O)c1c(=O)c2cc(F)c(F)c(F)c2n2c(CO)csc12,,O=S(=O)(O)O,,,,val
US20110183938A1,C[Si](C)(C)CCOCn1c2cnc(C#N)cc2c2c(Cl)ccnc21.O>>C[Si](C)(C)CCOCn1c2cnc(C#N)cc2c2c(O)ccnc21,O,CCOC(C)=O,O,C1CCOC1,[H-].[Na+],val
US04946865,C#CCOc1cc(C=O)cc(Cl)c1OCC#C.CO.COC(OC)OC>>C#CCOc1cc(C(OC)OC)cc(Cl)c1OCC#C,,CO,,[Cl-].[NH4+],,val
US20030153558A1,O=C(Cl)c1ccncc1.O=C(OCc1ccccc1)[C@@H]1CCCN1>>O=C(OCc1ccccc1)C1CCCN1C(=O)c1ccncc1,,c1ccncc1,,Cl,Cl,val
US20150152112A1,CN(C)C(=O)Cl.Nc1ccc(-c2cnc(C3CCc4cc(-c5cc(Cl)ccc5-n5cnnn5)cc(=O)n43)[nH]2)cc1>>CN(C)C(=O)Nc1ccc(-c2cnc(C3CCc4cc(-c5cc(Cl)ccc5-n5cnnn5)cc(=O)n43)[nH]2)cc1,,c1ccncc1,,ClCCl,,val
US20140275071A1,Cn1c(=O)n(CCOCCBr)c(=O)c2c1nc(Oc1cccc(OC(F)(F)F)c1)n2Cc1ccc(Cl)cc1.N>>Cn1c(=O)n(CCOCCN)c(=O)c2c1nc(Oc1cccc(OC(F)(F)F)c1)n2Cc1ccc(Cl)cc1,,CO,,,,val
US20050272779A1,CC#N.CCC(CC)(CC)C(C(=O)[O-])P(=O)(O)O.COc1ccc(-c2ncc(C=O)n2C2CC2)cc1>>CCOC(=O)C(C)=Cc1cnc(-c2ccc(OC)cc2)n1C1CC1,,CC#N,O,C1CCC2=NCCCN2CC1,,val
US20160015712A1,O=[N+]([O-])c1cnc(Cl)nc1Nc1ccc2ncccc2c1>>Nc1cnc(Cl)nc1Nc1ccc2ncccc2c1,[Ni],C1CCOC1,,,,val
US05556864,CC(C)(C)OC(=O)N1CCO[C@H](COc2ccccc2CCc2ccccc2)C1.Cl>>Cl.c1ccc(CCc2ccccc2OC[C@@H]2CNCCO2)cc1,,C1COCCO1,,,,val
US20070281933A1,Cc1nc(S(=O)(=O)Cl)cn1C.NC(=O)c1cc(-c2ccccc2)cc2c(C3CCNCC3)n[nH]c12>>Cc1nc(S(=O)(=O)N2CCC(c3n[nH]c4c(C(N)=O)cc(-c5ccccc5)cc34)CC2)cn1C,CN(C)c1ccncc1,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20020086890A1,CCCCCC#CCOc1ccc(S(=O)(=O)C2(C(=O)OCC)CCN(Cc3ccc(Br)cc3)CC2)cc1>>CCCCCC#CCOc1ccc(S(=O)(=O)C2(C(=O)O)CCN(Cc3ccc(Br)cc3)CC2)cc1,,C1CCOC1,,CO,[Na+].[OH-],val
US20100298298A1,CC(=O)Cl.COc1ccc(Cn2c(=O)c3cc(OCc4ccccc4)ccc3n(C3CCNCC3)c2=O)cc1OC>>COc1ccc(Cn2c(=O)c3cc(OCc4ccccc4)ccc3n(C3CCN(C(C)=O)CC3)c2=O)cc1OC,,ClCCl,,CCN(CC)CC,,val
US20130217759A1,CCOC(=O)c1c(NS(=O)(=O)c2ccccc2)sc(Br)c1C.OB(O)c1ccoc1>>CCOC(=O)c1c(NS(=O)(=O)c2ccccc2)sc(-c2ccoc2)c1C,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20100130739A1,CN(C(=O)CNc1c(Cl)cnnc1Cl)C1CCN(Cc2ccccc2)CC1.CO>>COc1cnnc(Cl)c1NCC(=O)N(C)C1CCN(Cc2ccccc2)CC1,,CO,,C[O-].[Na+],,val
US20160181534A1,COCCC1(CCOC)c2cc(Br)ccc2-c2ccc(Br)cc21.N#C[Cu]>>COCCC1(CCOC)c2cc(Br)ccc2-c2ccc(C#N)cc21,,Cl,O,CN(C)C=O,,val
US20060166990A1,CNC(=O)CCl.Cc1cc(Cl)ccc1Nc1ccc(C(=O)c2cc(O)ccc2F)c(Cl)c1>>CNC(=O)COc1ccc(F)c(C(=O)c2ccc(Nc3ccc(Cl)cc3C)cc2Cl)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050215577A1,CC(C#N)(C1CCCC(=O)C1)S(=O)(=O)c1ccccc1.Cc1ccc(NN)cc1>>Cc1ccc2[nH]c3c(c2c1)CCC(C(C)(C#N)S(=O)(=O)c1ccccc1)C3,,CC(=O)O,,Cl,O=C([O-])O.[Na+],val
US20160009667A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1noc2cc(COc3ccc(Cl)c(Cl)c3)c(Br)cc12>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1noc2cc(COc3ccc(Cl)c(Cl)c3)c(Br)cc12,CN(C)c1ccncc1,ClCCl,,,,val
US20130211075A1,CC(C)(C)C(=O)OC(=O)C(C)(C)C.CNC1CC=C(c2ncc(Br)cc2C)CC1>>Cc1cc(Br)cnc1C1=CCC(N(C)C(=O)C(C)(C)C)CC1,CN(C)c1ccncc1,c1ccncc1,,O,,val
US20160102088A1,COc1cc(Nc2ncc3c(n2)CCNC3)cc(OC)c1OC.Cc1ccoc1C(=O)O>>COc1cc(Nc2ncc3c(n2)CCN(C(=O)c2occc2C)C3)cc(OC)c1OC,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20040127574A1,CC(C)(C)C(F)(F)c1ccc(CC2NC(=O)OC2c2cccc(Cl)c2)cc1>>CC(C)(C)C(F)(F)c1ccc(CC(N)C(O)c2cccc(Cl)c2)cc1,,CCO,,[Na+].[OH-],,val
US20090239859A1,O=P(Cl)(Cl)Cl.O=c1[nH]c2c(-c3nnc[nH]3)cccc2c2cnccc12>>Clc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12,,CC#N,,,,val
US20120077810A1,CC1(O)CC(NC(=O)OC(C)(C)C)(c2ccc(-c3nc4nc(-c5ccccc5)nn4cc3-c3ccccc3)cc2)C1>>CC1(O)CC(N)(c2ccc(-c3nc4nc(-c5ccccc5)nn4cc3-c3ccccc3)cc2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140179667A1,COc1ccc(F)c(C(=O)O)c1Cl.Cc1cc(C)c(CNCCO)c(OCc2ccccc2)n1>>COc1ccc(F)c(C(=O)N(CCO)Cc2c(C)cc(C)nc2OCc2ccccc2)c1Cl,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20110288084A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C2CN2S(=O)(=O)c2ccccc2[N+](=O)[O-])CC1.N#Cc1ccc2ccc(=O)[nH]c2c1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C(Cn2c(=O)ccc3ccc(C#N)cc32)NS(=O)(=O)c2ccccc2[N+](=O)[O-])CC1,,CN(C)C=O,O,[H-].[Na+],,val
US20150065468A1,NNc1cnccn1.O=C1CCCCC1>>c1cnc(NN=C2CCCCC2)cn1,,CCO,,,,val
US04224325,Cc1cc(C)n(-c2ccc(Cl)nn2)n1.O=C1CCC(=O)N1Br>>Cc1nn(-c2ccc(Cl)nn2)c(C)c1Br,,ClC(Cl)(Cl)Cl,,,,val
US20080171772A1,Brc1nccs1.CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(O)cc2n1Cc1ccccc1>>CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(Oc3nccs3)cc2n1Cc1ccccc1,,CCOC(C)=O,CN(C)C=O,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20040167176A1,CC(C)(C)N=C=O.CC(C)Cc1cccs1>>CC(C)Cc1ccc(C(=O)NC(C)(C)C)s1,,C1CCOC1,,[Li]CCCC,,val
US04603201,CCOC(=S)[S-].Cc1c(Cl)cc(C(=O)C=CC(=O)O)cc1Cl>>CCOC(=S)SC(=CC(=O)c1cc(Cl)c(C)c(Cl)c1)C(=O)O,,O,,Cl,,val
US05278316,CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)O.Cn1cccc1CCN>>Cn1cccc1CCNC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3,,CCOC(C)=O,CN(C)C=O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US04886835,CCOC(=O)C(=O)C=CN(C)C.CC[O+](CC)CC.F[B-](F)(F)F>>CCOC(=O)C(=CC=[N+](C)C)OCC.F[B-](F)(F)F,,ClCCl,,,,val
US06100272,CC(=O)N1CCCc2cc(O)ccc21.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(=O)N1CCCc2cc(OS(=O)(=O)C(F)(F)F)ccc21,,C1CCOC1,,c1ccncc1,,val
US20100298293A1,CCCc1ccc[nH]c1=O.COc1cc([N+](=O)[O-])ccc1F>>CCCc1cccn(-c2ccc([N+](=O)[O-])cc2OC)c1=O,,CN(C)C=O,,O,CC(C)(C)[O-].[K+],val
US20100204196A1,COc1cc(Cl)ccc1[N+](=O)[O-].OB(O)c1cccnc1>>COc1cc(-c2ccncc2)ccc1[N+](=O)[O-],,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US06177462B1,CC(=O)C=Cc1cccc2ccccc12.NO>>CC(C=Cc1cccc2ccccc12)=NO,,CO,,Cl,[Na+].[OH-],val
US20100160323A1,CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)CC1C(=O)O.CI>>COC(=O)C1CN(C(=O)OCc2ccccc2)CCN1C(=O)OC(C)(C)C,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20080076740A1,CCOC(=O)C(C)OP(=O)(CCN1CCN(C(=O)OC(C)(C)C)CC1)Oc1ccccc1.O=C(O)C(F)(F)F>>CCOC(=O)C(C)OP(=O)(CCN1CCNCC1)Oc1ccccc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20040132727A1,CC(C)N(CCN)C(C)C.COc1cc2ncnc(Oc3ccc(N)c([N+](=O)[O-])c3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)NCCN(C(C)C)C(C)C)c([N+](=O)[O-])c3)c2cc1OC,,ClC(Cl)Cl,O,CCN(CC)CC,,val
US20120040378A1,CC(C)N=C=O.CCCC(C)(CO)CO>>CCCC(C)(CO)COC(=O)NC(C)C,,Cc1ccccc1,,O,,val
US20150361078A1,CC1CC(CO)CN1C(=O)OC(C)(C)C>>CC1CC(C=O)CN1C(=O)OC(C)(C)C,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20070054924A1,CCOC(=O)c1nnn(Cc2ccc(OC)cc2)c1SCC(F)(F)F>>CCOC(=O)c1nn[nH]c1SCC(F)(F)F,,O=C(O)C(F)(F)F,,,,val
US20110082172A1,CCI.COC(=O)C1CC(=O)N(c2c(C)cccc2C)C1>>CCC1(C(=O)OC)CC(=O)N(c2c(C)cccc2C)C1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20100216814A1,CC(Br)=C(C)c1ccc(F)cc1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>C/C(=C(/C)n1c2c(c3cc(C)ccc31)CN(C)CC2)c1ccc(F)cc1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20110281862A1,C1COCCO1.O=C([O-])[O-].O=S(=O)(c1ccccc1)n1c2ccc(Br)cc2c2cc(Cl)cnc21.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COc1ccc(/C=C/c2ccc3c(c2)c2cc(Cl)cnc2n3S(=O)(=O)c2ccccc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,,val
US20100216788A1,COC(=O)c1cccc(Oc2ccc([N+](=O)[O-])cc2C)c1>>Cc1cc([N+](=O)[O-])ccc1Oc1cccc(C(=O)O)c1,,CC(C)O,,Cl,[Na+].[OH-],val
US20110207781A1,Cc1cccc(C)c1O.O=CN1CCC[C@H]1CO>>Cc1cccc(C)c1OC[C@@H]1CCCN1C=O,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160221972A1,COC(=O)c1ccc2c(c1)OC[C@H](Cc1ccccc1)N(C(=O)N1CCOCC1)C2.NO>>O=C(NO)c1ccc2c(c1)OC[C@H](Cc1ccccc1)N(C(=O)N1CCOCC1)C2,,C1CCOC1,CO,[Na+].[OH-],,val
US05364869,CC(=O)O.COC1CCC(OC)O1.Cc1ccc(N)cc1>>Cc1ccc(-n2cccc2)cc1,,CCCCCC,,,,val
US20100075990A1,BrCc1ccccc1.c1ccc(-c2ncc(-c3c[nH]c(C4CCCNC4)n3)cn2)cc1>>c1ccc(CN2CCCC(c3ncc(-c4cnc(-c5ccccc5)nc4)[nH]3)C2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050209226A1,CC(C)(C)C(=O)OCC1CCNCC1.O=C1CCc2cc(F)c(F)cc2N1CCCCl>>CC(C)(C)C(=O)OCC1CCN(CCCN2C(=O)CCc3cc(F)c(F)cc32)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20140329794A1,CC(C)(C)OC(=O)N1CCC(c2cccc(C(=O)NCC(O)CN3CCc4ccccc4C3)c2)C1>>O=C(NCC(O)CN1CCc2ccccc2C1)c1cccc(C2CCNC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020091265A1,CC(C)(C(=O)Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.CNc1cnccc1-c1ccccc1Cl>>CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1-c1ccccc1Cl,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US04055595,ClCc1ccc(-c2ccc(Cl)cc2)cc1.N#CC(O)(C(F)(F)F)C(F)(F)F>>N#CC(OCc1ccc(-c2ccc(Cl)cc2)cc1)(C(F)(F)F)C(F)(F)F,,CN(C)C=O,O,[Na],,val
US20100075948A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.NC(=O)CC1CCNCC1>>CC(C)(C)C[C@@H]1N[C@@H](C(=O)N2CCC(CC(N)=O)CC2)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130079320A1,CS(=O)(=O)Cl.Cc1cc(C(C)C(=O)NCc2ccc(C(F)(F)F)nc2N2CCCC2)ccc1CN>>Cc1cc(C(C)C(=O)NCc2ccc(C(F)(F)F)nc2N2CCCC2)ccc1CNS(C)(=O)=O,,CCOC(C)=O,c1ccncc1,,,val
US20120122842A1,NNC(=O)c1ccc[nH]1.O=C(Cl)c1ccc(Br)cc1>>O=C(NNC(=O)c1ccc[nH]1)c1ccc(Br)cc1,,C1CCOC1,,c1ccncc1,,val
US20070219186A1,O=C(Nc1ccc(Cl)c(-c2ccnc3ccnn23)c1)c1cccc(C(F)(F)F)c1.O=C1CCC(=O)N1I>>O=C(Nc1ccc(Cl)c(-c2ccnc3c(I)cnn23)c1)c1cccc(C(F)(F)F)c1,,ClC(Cl)Cl,,,,val
US04353908,CCOC(=O)Cl.Cc1cc(O)nc(C(Cl)(Cl)Cl)n1>>CCOC(=O)Oc1cc(C)nc(C(Cl)(Cl)Cl)n1,,CCOCC,,CCN(CC)CC,,val
US20020052512A1,COC(=O)C1CSCCC12OCCO2>>O=C(O)C1CSCCC12OCCO2,,CCO,,[K+].[OH-],,val
US20150210688A1,C1CO1.Cc1nccn1S(=O)(=O)N(C)C>>Cc1nc(CCO)cn1S(=O)(=O)N(C)C,,C1CCOC1,,[Li]CCCC,,val
US20070244173A1,COCCO.Cn1c(C2CC2)nc2c3c(ccc21)[C@@H](O)[C@H](O)[C@@H](c1ccccc1)O3>>COCCO[C@H]1c2ccc3c(nc(C4CC4)n3C)c2O[C@H](c2ccccc2)[C@H]1O,,COCCO,,O=S(=O)(O)O,,val
US20120184546A1,Nc1cc(S(N)(=O)=O)ccc1C(=O)O.O=C(O)Cc1ccc2c(c1)OCO2>>NS(=O)(=O)c1ccc(C(=O)O)c(NC(=O)Cc2ccc3c(c2)OCO3)c1,,CN(C)C=O,ClCCl,,,val
US05726124,C#CCn1c(-c2ccccc2)nc(CC)c(CC(=O)OC)c1=O>>C#CCn1c(-c2ccccc2)nc(CC)c(CCO)c1=O,,C1CCOC1,CCOCC,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US04992462,CC(C)C(=O)CC(C(=O)c1ccccc1)c1ccc(F)cc1.CN>>CC(C)c1cc(-c2ccc(F)cc2)c(-c2ccccc2)n1C,,CCO,,,,val
US04933472,CCOP(=O)(OCC)C(NC1CCSCC1)P(=O)(OCC)OCC>>O=P(O)(O)C(NC1CCSCC1)P(=O)(O)O,,Cl,,,,val
US20120108568A1,CCOC=CC(=O)OCC.N#Cc1cn[nH]c1N>>N#Cc1cnn2ccc(O)nc12,,CN(C)C=O,O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20130303507A1,Clc1cncc(Cl)n1.N#CC1(CO)CCOCC1>>N#CC1(COc2cncc(Cl)n2)CCOCC1,,C1CCOC1,,O,[H-].[Na+],val
US04152433,CC1C=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(NC(=O)C(=NO)C(=O)CBr)[C@H]2S1.NC(N)=S>>CC1C=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(NC(=O)C(=NO)c3csc(N)n3)[C@H]2S1,,CCO,,,,val
US20150126492A1,COC(=O)C[C@@H](NC(=O)OC(C)(C)C)c1ccc(F)cc1>>COC(=O)C[C@@H](N)c1ccc(F)cc1,,C1COCCO1,,Cl,,val
US04578465,CCOC(=O)CCCn1c(=O)n(CCN2CCN(c3ccccc3OC)CC2)c(=O)c2ccccc21>>COc1ccccc1N1CCN(CCn2c(=O)c3ccccc3n(CCCC(=O)O)c2=O)CC1,,CCO,,[Na+].[OH-],,val
US20100093730A1,O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O.c1ccc(C2CCNC2)cc1>>O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)N1CCC(c2ccccc2)C1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US06222034B1,CCOC(=O)c1c(N=C(C)OCC)sc2c1CCN(C)C2.COc1ccccc1N1CCN(CCN)CC1>>COc1ccccc1N1CCN(CCn2c(C)nc3sc4c(c3c2=O)CCN(C)C4)CC1,,CCO,,,,val
US05650510,CC1(C)OCC(COCc2ccccc2)CO1>>OCC(CO)COCc1ccccc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US06620961B1,COC(=O)NCc1cccc(-c2ccccc2)c1.COCBr>>COCN(Cc1cccc(-c2ccccc2)c1)C(=O)OC,,C1CCOC1,,O,[H-].[Na+],val
US20050261333A1,Clc1cnc2[nH]c(-c3ccc(OCCN4CCOCC4)cc3)nc2c1Cl.OCCNCc1ccccc1>>OCCN(Cc1ccccc1)c1c(Cl)cnc2nc(-c3ccc(OCCN4CCOCC4)cc3)[nH]c12,,CC#N,,,,val
US05306728,OCCCc1cccc(-c2ccsc2)c1>>O=CCCc1cccc(-c2ccsc2)c1,,ClC(Cl)Cl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20060276515A1,CS(=O)(=O)CCN.O=C(NCCC(c1ccccc1)c1ccccc1)c1cccnc1F>>CS(=O)(=O)CCNc1ncccc1C(=O)NCCC(c1ccccc1)c1ccccc1,,C1CCOC1,,,,val
US20090163712A1,CC(=O)OCBr.CCn1c(C(=O)c2cc(C)cc(C#N)c2)c(C(C)C)c(=O)[nH]c1=O>>CCn1c(C(=O)c2cc(C)cc(C#N)c2)c(C(C)C)c(=O)n(COC(C)=O)c1=O,,CN(C)C=O,O,[H-].[Na+],,val
US20090023702A1,CCCc1cnc(N2CCC(O)CC2)nc1.CS(=O)(=O)Cl>>CCCc1cnc(N2CCC(OS(C)(=O)=O)CC2)nc1,,ClCCl,,CCN(CC)CC,,val
US05480857,CN(C)C=C(C(=O)c1ncc(Cl)cc1Cl)C(=O)C1CC1.NO>>O=C(c1cnoc1C1CC1)c1ncc(Cl)cc1Cl,,CCO,,Cl,,val
US20080015199A1,CC(=O)O.COc1cc(OCCO[Si](C)(C)C(C)(C)C)c(F)c(C(Nc2ccc(-c3noc(C)n3)cc2)c2nn(-c3ncccc3[N+](=O)[O-])c(=O)[nH]2)c1>>CC(=O)O.COc1cc(OCCO)c(F)c(C(Nc2ccc(C(=N)N)cc2)c2nn(-c3ncccc3N)c(=O)[nH]2)c1,[Fe],CC(=O)O,,CO,O,val
US20110201593A1,CC=O.CCOC(=O)C1=C(O)C(F)(F)CN(Cc2ccccc2)C1>>CCOC(=O)C1=C(O)C(F)(F)CN(CC)C1,[Pd],CCOC(C)=O,,,,val
US20160095858A1,Cc1cc(C)c(Oc2nc(Cl)ccc2C(=O)O)c(C)c1.NS(=O)(=O)c1cccc(F)n1>>Cc1cc(C)c(Oc2nc(Cl)ccc2C(=O)NS(=O)(=O)c2cccc(F)n2)c(C)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100331320A1,C=CC[Mg]Cl.COCC(=O)c1ccccc1>>C=CCC(O)(COC)c1ccccc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20060252812A1,CCCCCN1C(=O)C(CC(=O)OC)(c2ccc3c(c2)OCO3)c2ccccc21>>CCCCCN1C(=O)C(CC(=O)O)(c2ccc3c(c2)OCO3)c2ccccc21,,C1CCOC1,O,[Li+].[OH-],,val
US20150284395A1,COC(OC)N(C)C.Cc1cnoc1CC#N>>Cc1cnoc1C(C#N)=CN(C)C,,Cc1ccccc1,,,,val
US20050227987A1,COc1cccc(CC(=O)Cl)c1.Cc1nc2c(Cl)c(N)ccc2s1>>COc1cccc(CC(=O)Nc2ccc3sc(C)nc3c2Cl)c1,,C1CCOC1,,CCN(CC)CC,,val
US04788206,CCOC(=O)/C=C/C=C(c1cccc(OC)c1)c1cccc(OC)c1>>COc1cccc(C(=C/C=C/C(=O)O)c2cccc(OC)c2)c1,,[Na+],[OH-],,,val
US20100160302A1,CCCCOC(=O)NC12CC3CC1CC(Cn1cnnn1)(C3)C2>>NC12CC3CC1CC(Cn1cnnn1)(C3)C2,,CCOC(C)=O,,Cl,,val
US05714489,CC(=O)O.COC1CCC(OC)O1.Nc1cc2[nH]c(=O)c(=O)n(C3CCCCC3)c2cc1[N+](=O)[O-]>>O=c1[nH]c2cc(-n3cccc3)c([N+](=O)[O-])cc2n(C2CCCCC2)c1=O,,CC(=O)O,O,,,val
US04085226,Nc1ccc(Cl)c(C(F)(F)F)c1.O=C=NC(=O)c1c(F)cccc1F>>O=C(NC(=O)c1c(F)cccc1F)Nc1ccc(Cl)c(C(F)(F)F)c1,,Cc1ccccc1,,,,val
US04578392,BrBr.CC(C)c1cc2ccccn2n1>>CC(C)c1nn2ccccc2c1Br,,ClC(Cl)Cl,,O=S([O-])O.[Na+],,val
US20150087663A1,CC[C@H](NC(=O)OC(C)(C)C)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1F>>CC[C@H](N)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1F,,CCOC(C)=O,,Cl,,val
US05312920,CCCCC(=O)CC(=O)OC.O=Cc1ccc(Br)cc1>>CCCCC(=O)C(=Cc1ccc(Br)cc1)C(=O)OC,,Cc1ccccc1,,C1CCNCC1,CC(=O)O,val
US20070099990A1,C=CCc1c(C)cc(C)cc1O>>Cc1cc(C)c2c(c1)OC(C)C2,,CO,,Cl,[Na+].[OH-],val
US20130053364A1,CCN(CC)C/C=C\c1cc(F)ccc1S(=O)(=O)Cc1ccc(-c2ccoc2)c(OC)c1C(=O)OC.CCOC(=O)c1c(CS(=O)(=O)c2ccccc2)cc(OC)c(I)c1OC>>CCOC(=O)c1c(CS(=O)(=O)c2ccccc2)cc(OC)c(-c2ccoc2)c1OC,,C1CCOC1,,,,val
US20160016968A1,CC(C)(C)C(=O)Cl.NC(=NO)c1cc(OCC(F)(F)F)c(C2CC2)cn1>>CC(C)(C)c1nc(-c2cc(OCC(F)(F)F)c(C3CC3)cn2)no1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100184809A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(N)c(C(F)(F)F)n1.COC(=O)c1ccc(C(=O)Cl)cc1>>COC(=O)c1ccc(C(=O)Nc2ccc(OCc3c(-c4c(Cl)cccc4Cl)noc3C(C)C)nc2C(F)(F)F)cc1,,ClCCl,,CCN(CC)CC,,val
US20110251178A1,OCc1cc(-c2ccc(F)cc2)nn1CCCl>>Fc1ccc(-c2cc3n(n2)CCOC3)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20090023917A1,Oc1ccc2c(C(O)c3ccc(OCCN4CCCCC4)cc3)c(-c3ccc(F)cc3F)ccc2c1>>Oc1ccc2c3c(ccc2c1)-c1ccc(F)cc1OC3c1ccc(OCCN2CCCCC2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US06153640,N#CCCN(Cc1ccccc1)CC(O)c1ccccc1Br.O=S(Cl)Cl>>N#CCCN(Cc1ccccc1)CC(Cl)c1ccccc1Br,,ClCCl,,,,val
US20040082607A1,CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)C)c(=O)c2ccc(-c3nnn[nH]3)cc12.Cl>>CCCCOc1c(CN)n(CC(C)C)c(=O)c2ccc(-c3nnn[nH]3)cc12.Cl,,CCOC(C)=O,,,,val
US20110112080A1,CC(C)(C)OC(=O)N1[C@@H](CCc2ccc(N)cc2)COC1(C)C.O=C=Nc1ccc(Cl)c(Cl)c1>>CC(C)(C)OC(=O)N1[C@@H](CCc2ccc(NC(=O)Nc3ccc(Cl)c(Cl)c3)cc2)COC1(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100256156A1,CCCC[Mg]Br.Cc1oc(-c2ccccc2)cc1C=O>>CCCCC(O)c1cc(-c2ccccc2)oc1C,,C1CCOC1,,Cl,O,val
US20140057926A1,CSc1ccc(C#N)c(F)c1>>CSc1ccc(CN)c(F)c1,[Ni],CO,,N,[H][H],val
US06475247B1,CI.O=C(NCCCN1CCOCC1)c1cc2ccccc2cc1O>>C[N+]1(CCCNC(=O)c2cc3ccccc3cc2O)CCOCC1.[I-],,Clc1ccccc1,,,,val
US20100137250A1,CO.COC(=O)Cc1cc(C(O)c2ccc(S(C)(=O)=O)cc2)c2cc(F)ccc2c1>>COC(=O)Cc1cc(C(OC)c2ccc(S(C)(=O)=O)cc2)c2cc(F)ccc2c1,O=S(=O)(O)O,,,,,val
US20080275042A1,Nc1ccc(CO)cc1.O=C(Cl)OCC1c2ccccc2-c2ccccc21>>O=C(Nc1ccc(CO)cc1)OCC1c2ccccc2-c2ccccc21,,C1CCOC1,CCOC(C)=O,c1ccncc1,,val
US04072688,O=C(Cl)C(Br)CBr.c1ccc(C2CNC(c3ccccc3)O2)cc1>>O=C(C(Br)CBr)N1CC(c2ccccc2)OC1c1ccccc1,,CCN(CC)CC,,ClCCl,,val
US20110034469A1,CCO[C@@H]1C[C@@H]2CN(C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C3CCC(F)(F)CC3)[C@H](C(=O)N[C@@H]3CCOc4ccccc43)CN2C1>>CCO[C@@H]1C[C@@H]2CN(C(=O)[C@@H](NC(=O)[C@H](C)NC)C3CCC(F)(F)CC3)[C@H](C(=O)N[C@@H]3CCOc4ccccc43)CN2C1,,CCOC(C)=O,Cl,,,val
US20090312321A1,CC(=O)OC(C)=O.CCn1c(=N)c(-c2cc(OC)cc(C(=O)OC)c2)cc2cnc(SC)nc21>>CCn1c(=O)c(-c2cc(OC)cc(C(=O)O)c2)cc2cnc(SC)nc21,,O,,Cl,,val
US05374641,CCOC(=O)C=Cc1ccc(CC(=O)c2cccnc2)cc1.O=C[O-].[NH4+]>>CCOC(=O)C=Cc1ccc(CC(NC=O)c2cccnc2)cc1,,O,,,,val
US20090111791A1,CC(C)(C)OC(=O)NC1CCN(C(=O)Nc2ccc(Cl)cc2Cl)CC1>>NC1CCN(C(=O)Nc2ccc(Cl)cc2Cl)CC1,,ClCCl,,C1COCCO1,Cl,val
US20090247538A1,CC(C)(C)OC(=O)NC1CCNCC1.Clc1ncnc2[nH]ncc12>>CC(C)(C)OC(=O)NC1CCN(c2ncnc3[nH]ncc23)CC1,,CCO,,CCN(CC)CC,,val
US20090209585A1,O=C(Cl)C(=O)Cl.O=C(O)CCC(=O)OCC(=O)c1ccccc1>>O=C(Cl)CCC(=O)OCC(=O)c1ccccc1,,CN(C)C=O,,C1CCOC1,,val
US20020091148A1,NNC(=O)c1[nH]c2ccccc2c1-c1ccc(OC(F)(F)F)cc1.O=Cc1ccc(Br)cc1>>O=C(NN=Cc1ccc(Br)cc1)c1[nH]c2ccccc2c1-c1ccc(OC(F)(F)F)cc1,,CCO,,,,val
US20120202799A1,COC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc21>>COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)O)c1nnc(C)n1-2,,C1CCOC1,,[Na+].[OH-],,val
US20060004043A1,C[C@H]1CCC[C@@H](C)N1CCO.Oc1ccc2cc(Br)ccc2c1>>C[C@H]1CCC[C@@H](C)N1CCOc1ccc2cc(Br)ccc2c1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040204427A1,COc1ccc(N2Cc3cnc(Nc4ccccc4)nc3N([C@@H]3CC[C@@H](O[Si](C)(C)C(C)(C)C)C3)C2=O)cc1>>COc1ccc(N2Cc3cnc(Nc4ccccc4)nc3N([C@@H]3CC[C@@H](O)C3)C2=O)cc1,,ClCCl,O=C(O)C(F)(F)F,O,,val
US20050191527A1,Nc1ccccc1N.O=C(C(=O)c1ccccc1)c1ccccc1>>c1ccc(-c2nc3ccccc3nc2-c2ccccc2)cc1,,CCO,,O,,val
US20090214675A1,C/C(N)=C/C(=O)OC(C)C.CC([O-])=CC#N.Cc1cc(=O)c2c(F)ccc(C=O)c2o1>>CC1=C(C#N)C(c2ccc(F)c3c(=O)cc(C)oc23)C(C(=O)OC(C)C)=C(C)N1,,CC(C)O,,CC(=O)O,,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4c(CC#N)cccc4nn23)CC1.Cl>>Cl.N#CCc1cccc2nn3c(C4CCNCC4)cc(=O)[nH]c3c12,,C1COCCO1,CO,,,val
US20100105659A1,c1ccc(COc2cccn3cnnc23)cc1>>Oc1cccn2cnnc12,[Pd],CCO,,,,val
US20060235222A1,CON(C)C(=O)c1cc2c(F)cccc2s1.C[Mg]Br>>CC(=O)c1cc2c(F)cccc2s1,,CCOCC,,C1CCOC1,,val
US04268510,CCCN.O=C(Cl)c1ccc2c(c1)C(=O)NC(C(Cl)(Cl)Cl)O2>>CCCNC(=O)c1ccc2c(c1)C(=O)NC(C(Cl)(Cl)Cl)O2,,CO,,,,val
US20080269193A1,CC(C)(C)OC(=O)NCC(=O)O.CCc1nn(-c2cc(F)c(C(N)=O)c(NC3CCC(O)CC3)c2)c2c1C(=O)CC(C)(C)C2>>CCc1nn(-c2cc(F)c(C(N)=O)c(N[C@@H]3CC[C@@H](OC(=O)CNC(=O)OC(C)(C)C)CC3)c2)c2c1C(=O)CC(C)(C)C2,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20130267526A1,Cc1c(Cl)nc2ncccc2c1Cl.Cc1ccccc1.OB(O)c1ccccc1>>Cc1c(-c2ccccc2)nc2ncccc2c1-c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O,O=C([O-])[O-].[Na+].[Na+],val
US04937343,O=C1c2cc(F)ccc2S(=O)(=O)N1CCCBr.c1cnc(N2CCNCC2)nc1>>O=C1c2cc(F)ccc2S(=O)(=O)N1CCCN1CCN(c2ncccn2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06936602B1,CCCCOCCOc1ccc(OB([O-])[O-])cc1.CN(Cc1ccc(NC(=O)C2=Cc3cc(Br)ccc3N(C3CC3)CC2)cc1)C1CCOCC1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CCN3C2CC2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[K+].[K+],val
US20130225584A1,Nc1cccnc1.O=C(O)c1cc(Cl)c(C(=O)N2CCOCC2)cc1OCc1ccccc1>>O=C(Nc1cccnc1)c1cc(Cl)c(C(=O)N2CCOCC2)cc1OCc1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060019956A1,N#CCC(=O)c1ccncc1.NO>>Nc1cc(-c2ccncc2)no1,,CCO,,Cl,,val
US20090221555A1,CN1C(=O)OCCc2cc(N)ccc21.Fc1cccc(OCCOC2CCCCO2)c1Nc1nc(Cl)ncc1Cl>>CN1C(=O)OCCc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4OCCO)n3)ccc21,,CC(C)O,,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US20090062351A1,COC(=O)c1cc(O)cc(OCc2ccccc2)c1.COCC(C)O>>COC[C@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)OC)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110021537A1,CC(C)(C)OC(=O)CC[C@H](NC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1)C(=O)O.O=C(Oc1ccccc1)N1CCNCC1>>O=C(O)CC[C@H](NC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1)C(=O)N1CCN(C(=O)Oc2ccccc2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090186870A1,O=C(O)c1ccc(Cl)cc1Cl.O=[N+]([O-])O>>O=C(O)c1cc([N+](=O)[O-])c(Cl)cc1Cl,,O=S(=O)(O)O,,,,val
US06057352,CCOP(=O)(OCC)C(Cl)(Cl)C(=O)OC(C)(C)C>>CCOP(=O)(OCC)C(Cl)C(=O)OC(C)(C)C,,CCO,O,O=S([O-])[O-].[Na+].[Na+],,val
US05977410,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C(NCCOc1ccc(OC(F)(F)F)cc1)c1c(F)cccc1F>>Fc1cccc(F)c1C(=S)NCCOc1ccc(OC(F)(F)F)cc1,,Cc1ccccc1,,,,val
US20110218193A1,COCn1c(=O)c2c(c3c(OC)cc(C=O)cc31)NCCC2.NN1CCOCC1>>COCn1c(=O)c2c(c3c(OC)cc(/C=N/N4CCOCC4)cc31)NCCC2,,Cc1ccccc1,,,,val
US20070099990A1,Cc1c(Br)c2c(c(C)c1NC(=O)OC(C)(C)C)C(=O)C(C)(C)O2>>Cc1c(Br)c2c(c(C)c1NC(=O)OC(C)(C)C)C(O)C(C)(C)O2,,CCCCCC,CCOC(C)=O,,,val
US20120232051A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCC1COC1>>Cc1ccc(S(=O)(=O)OCC2COC2)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,Cl,val
US06093744,CC(C)c1cc(C(C)C)c(CC(=O)NS(=O)(=O)Oc2c(C(C)C)cc(C=O)cc2C(C)C)c(C(C)C)c1.CCC(C#N)(CC)O[PH](=O)[O-]>>CC(C)c1cc(C(C)C)c(CC(=O)NS(=O)(=O)Oc2c(C(C)C)cc(C=CC#N)cc2C(C)C)c(C(C)C)c1,,C1CCOC1,,[H-].[Na+],,val
US20030166639A1,CCc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccnc(C#N)c3)c2)cc1C(F)(F)F>>CCc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3ccnc(C#N)c3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140051679A1,C[C@H]1CCCN1.O=CC(=O)O.OB(O)c1ccsc1>>C[C@H]1CCCN1[C@H](C(=O)O)c1ccsc1,,ClCCl,,CO,O,val
US20100204209A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.NCCCN1CCOCC1>>CC(C)(C)OC(=O)N1CCC(C(=O)NCCCN2CCOCC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20070249670A1,COC(=O)C1(NC(=O)c2ccc(F)cc2N)CCCCCC1.Cc1cc(C)c(N=C=O)c(C)c1>>COC(=O)C1(NC(=O)c2ccc(F)cc2NC(=O)Nc2c(C)cc(C)cc2C)CCCCCC1,,c1ccncc1,,CCCCCC,CCOC(C)=O,val
US20130018044A1,COC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1ccc(NC(=O)OC(C)(C)C)nc1>>COC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1ccc(N)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100267689A1,CC(C)(C)S(N)=O.O=C1CCC2(CC1)OCCO2>>CC(C)(C)S(=O)N=C1CCC2(CC1)OCCO2,,C1CCOC1,,,,val
US20160016935A1,FC(F)CI.Oc1ccnc(F)c1>>Fc1cc(OCC(F)F)ccn1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20060128790A1,CON=CC1=Cc2c(cc(C)c(O)c2C)OC12CCC2>>CONCC1=Cc2c(cc(C)c(O)c2C)OC12CCC2,,C1CCOC1,C1COCCO1,Cl,,val
US20120165347A1,CC(C)(C)S(=O)N=C1c2cc(Br)ccc2CC12CCC(C(F)F)CC2>>N=C1c2cc(Br)ccc2CC12CCC(C(F)F)CC2,,C1COCCO1,,Cl,,val
US20030134885A1,COCCOCOc1ccc(-c2ccc(C(=O)N(C)Cc3cccc(-c4ccc(CC5SC(=O)NC5=O)cc4)c3)cc2)cc1>>CN(Cc1cccc(-c2ccc(CC3SC(=O)NC3=O)cc2)c1)C(=O)c1ccc(-c2ccc(O)cc2)cc1,,CO,,O=S(=O)(O)O,,val
US05854275,CNC(=O)C(Cc1ccc(OC)cc1)NC(=O)C1(CC(CCN2C(=O)c3cc4ccccc4cc3C2=O)C(=O)OC(C)(C)C)CCCCC1>>CNC(=O)C(Cc1ccc(OC)cc1)NC(=O)C1(CC(CCN2C(=O)c3cc4ccccc4cc3C2=O)C(=O)O)CCCCC1,,O=C(O)C(F)(F)F,,CCOCC,,val
US20130190262A1,COc1nc(C)ccc1-c1cc(Nc2cncc(O[C@@H]3CCCNC3)n2)[nH]n1.O>>COc1nc(C)ccc1-c1cc(Nc2cncc(O[C@@H]3CCCNC3)n2)[nH]n1.O,,CCO,O,,,val
US20040157891A1,COc1ccc(-c2oc(C(=O)C(C)C)nc2-c2ccc(OCc3ccccc3)cc2)cc1>>COc1ccc(-c2oc(C(=O)C(C)C)nc2-c2ccc(O)cc2)cc1,[Pd],C1COCCO1,CO,,,val
US20130001521A1,CCOP(=O)(Cc1ccc(-c2ccc3c4ccccc4c4ccccc4c3c2)cc1)OCC.O=Cc1ccc(N(c2ccccc2)c2ccccc2)cc1>>C(=C/c1ccc(N(c2ccccc2)c2ccccc2)cc1)\c1ccc(-c2ccc3c4ccccc4c4ccccc4c3c2)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20100143252A1,CI.N#CNc1cccc(SCc2ccccc2)c1>>CN(C#N)c1cccc(SCc2ccccc2)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20110034461A1,CCOc1cc(C(=O)N(C)OC)cc(S(F)(F)(F)(F)F)c1.C[Mg]Br>>CCOc1cc(C(C)=O)cc(S(F)(F)(F)(F)F)c1,,C1CCOC1,,,,val
US20100311966A1,CC(C)(C)OC(=O)N1CCC(=O)C(OCc2ccccc2)C1.NCc1ccccc1>>CC(C)(C)OC(=O)N1CC[C@H](NCc2ccccc2)[C@H](OCc2ccccc2)C1,,ClCCCl,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040048916A1,CC(C)CN1C(=O)c2ccccc2C1O.CCOCC>>CCOC(=O)CC1c2ccccc2C(=O)N1CC(C)C,,COCCOC,,O,[H-].[Na+],val
US20160221972A1,COC(=O)c1cnc(C)c(Br)c1.O=C1CCC(=O)N1Br>>COC(=O)c1cnc(CBr)c(Br)c1,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20070276011A1,Cc1cc(C=O)cc(C(=O)O)c1O.OCc1ccccc1>>Cc1cc(C=O)cc(C(=O)OCc2ccccc2)c1O,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060223849A1,COc1cccc2cc(C(=O)O)ncc12.Nc1nc2cccc(C(=O)Nc3ncc[nH]3)c2[nH]1>>COc1cccc2cc(C(=O)Nc3nc4c(C(=O)Nc5ncc[nH]5)cccc4[nH]3)ncc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090253679A1,CC(=O)n1cc(/C=C2\N=C(C)OC2=O)c2cccnc21.CN>>CC1=N/C(=C\c2c[nH]c3ncccc23)C(=O)N1C,,CCO,,,,val
US20120298966A1,Brc1cccc([Si](c2ccccc2)(c2ccccc2)c2cccc(Br)c2)c1.OB(O)c1ccc2sc3ccccc3c2c1>>Brc1cccc([Si](c2ccccc2)(c2ccccc2)c2cccc(-c3ccc4sc5ccccc5c4c3)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,O=C([O-])[O-].[K+].[K+],,val
US20080275046A1,CC1CCCN1.ClCCCOc1ccc(-c2nc(CN3CCCCC3)co2)cc1Cl>>CC1CCCN1CCCOc1ccc(-c2nc(CN3CCCCC3)co2)cc1Cl,,CC#N,,[I-].[Na+],,val
US20120157430A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOc1c(C(C)N)cc(Cl)c(C)c1C1CN(C(=O)OCc2ccccc2)C1>>CCOc1c(C(C)NC(=O)OC(C)(C)C)cc(Cl)c(C)c1C1CN(C(=O)OCc2ccccc2)C1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20090042852A1,CC(C)(C)OC(=O)N1CCN(c2ncc(C(=N)NO)cc2Cl)CC1.CCC(=O)Cl>>CCc1nc(-c2cnc(N3CCN(C(=O)OC(C)(C)C)CC3)c(Cl)c2)no1,,c1ccncc1,,,,val
US20020052369A1,CN(C)CCOc1ccc2[nH]c(C=O)cc2c1.O=C1Cc2ccccc2N1>>CN(C)CCOc1ccc2[nH]c(C=C3C(=O)Nc4ccccc43)cc2c1,,CCO,,C1CCNCC1,,val
US20100087427A1,COCCOc1cc(C(=O)N(C[C@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2Cc2ccccc2)C(C)C)ccc1OC>>COCCOc1cc(C(=O)N(C[C@H]2CNC[C@@H]2Cc2ccccc2)C(C)C)ccc1OC,,ClCCl,,O=C(O)C(F)(F)F,,val
US04939159,CC(=O)Cc1ccc(F)cc1.NNc1ccccn1>>CC(Cc1ccc(F)cc1)=NNc1ccccn1,,O,,Cc1ccccc1,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(CCC)c2ncnn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(CCC)c2ncnn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US05192781,CCCC(=O)C(Cl)Cc1ccc([N+](=O)[O-])cc1.CSCC(N)=S>>CCCc1nc(CSC)sc1Cc1ccc([N+](=O)[O-])cc1,,C1CCCCC1,CCOC(C)=O,,,val
US20090036492A1,O=Cc1ccc(F)c2ccccc12.Oc1ccc(Cl)cc1>>O=Cc1ccc(Oc2ccc(Cl)cc2)c2ccccc12,,CS(C)=O,,Cl,[H-].[Na+],val
US20120258948A1,C[C@@](CCn1ccc(-c2ccc(F)cc2)cc1=O)(C(=O)NOC1CCCCO1)S(C)(=O)=O>>C[C@@](CCn1ccc(-c2ccc(F)cc2)cc1=O)(C(=O)NO)S(C)(=O)=O,,CC(C)O,,Cl,,val
US20120289526A1,CC(C)c1cc(O)ccc1C#N.CC1(C)NC(=O)N(c2ccc(F)nc2)C1=O>>CC(C)c1cc(Oc2ccc(N3C(=O)NC(C)(C)C3=O)cn2)ccc1C#N,,CN(C)C=O,O,CCOCC,O=C([O-])[O-].[K+].[K+],val
US05665725,CCOC(=O)N1CCC(=O)CC1.Oc1ccccc1O>>CCOC(=O)N1CCC2(CC1)Oc1ccccc1O2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20100022570A1,Cn1cc(C(=O)Cl)c(C(F)F)n1.NC1CC1(F)c1ccc(Cl)cc1>>Cn1cc(C(=O)NC2CC2(F)c2ccc(Cl)cc2)c(C(F)F)n1,,ClCCl,,CCN(CC)CC,,val
US20160083370A1,Cc1ccc(S(=O)(=O)OCCCc2c[nH]c3ccc(C#N)cc23)cc1.NC(=O)c1ccnc(N2CCNCC2)n1>>N#Cc1ccc2[nH]cc(CCCN3CCN(c4nccc(C(N)=O)n4)CC3)c2c1,,CC#N,,[I-].[K+],,val
US04611056,CC(=O)Oc1c2c(c3ccccc3c1OC(C)=O)N(C(C)=O)c1ccccc1S2>>CC(=O)N1c2ccccc2Sc2c(O)c(O)c3ccccc3c21,,CC(C)=O,,CC(=O)O,[Na+].[OH-],val
US20110105463A1,N#CCc1cc(Cl)cc(Cl)c1>>NCCc1cc(Cl)cc(Cl)c1,,C1CCOC1,CCOCC,Cl,[Na+].[OH-],val
US20150299189A1,C=CCOC(=O)c1cc(C2CC2)ccc1Nc1ccc2[nH]ccc2c1.O=C(Cl)c1ccc(Cl)cc1>>C=CCOC(=O)c1cc(C2CC2)ccc1Nc1ccc2c(ccn2C(=O)c2ccc(Cl)cc2)c1,CN(C)c1ccncc1,CCN(CC)CC,ClCCl,CCOC(C)=O,O=C([O-])O.[Na+],val
US20110213003A1,COC(=O)c1ccc(C(C)N)s1.O=C=NC1CCCC1>>COC(=O)c1ccc(C(C)NC(=O)NC2CCCC2)s1,,ClCCCl,,CCN(C(C)C)C(C)C,Cl,val
US20150291573A1,CCI.O=S(=O)(c1cccc(C(F)(F)F)c1)[C@H]1CCO[C@@H](c2ccc(Cl)cc2)C1>>CCC1(S(=O)(=O)c2cccc(C(F)(F)F)c2)CCOC(c2ccc(Cl)cc2)C1,,C1CCOC1,CCOC(C)=O,CC(C)(C)[O-].[K+],,val
US05571810,CS(=O)(=O)c1ccc(-c2ccsc2-c2ccc(F)cc2)cc1.O=[N+]([O-])O>>CS(=O)(=O)c1ccc(-c2cc([N+](=O)[O-])sc2-c2ccc(F)cc2)cc1,,CC(=O)OC(C)=O,,O=C([O-])O.[Na+],,val
US20050038072A1,O=C1CCNCC1C(c1ccccc1)c1ccccc1.OCc1ccccc1O>>O=C1CCN(Cc2ccccc2O)CC1C(c1ccccc1)c1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20110039840A1,COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCN(C(=O)OC(C)(C)C)CC1)O2.Fc1ccc(CCBr)cc1>>COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCN(CCc3ccc(F)cc3)CC1)O2,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120149632A1,C=CCO.O=C(O)CNCC(=O)O.c1ccccc1>>C=CCOC(=O)CNCC(=O)OCC=C,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120010247A1,CCOc1ccc(CSc2ccc3oc(C(C)NC(C)=O)cc3c2)cc1.O=C(OO)c1cccc(Cl)c1>>CCOc1ccc(CS(=O)c2ccc3oc(C(C)NC(C)=O)cc3c2)cc1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US08637551B2,N.O=Cc1ccccc1-c1noc2cc(C(=O)O)ccc12>>NC(=O)c1ccc2c(-c3ccccc3C=O)noc2c1,,CN1CCCC1=O,,O=C(n1ccnc1)n1ccnc1,,val
US20060276447A1,CC(C)(C)OC(=O)NC1CN(c2ccc(C(F)(F)F)cn2)C1>>NC1CN(c2ccc(C(F)(F)F)cn2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110028450A1,CCOC(=O)c1c(C=O)c(-c2cccs2)c2n1CCc1cc(OC)c(OC(C)C)cc1-2>>COc1cc2c(cc1OC(C)C)-c1c(-c3cccs3)c(C=O)c(C(=O)O)n1CC2,,CCO,,[Na+].[OH-],,val
US20050250792A1,O=C(Cc1ccc(F)cc1)NC1CCNCC1.O=Cc1ccc2ccccc2n1>>O=C(Cc1ccc(F)cc1)NC1CCN(Cc2ccc3ccccc3n2)CC1,,CC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20080167378A1,CC1=CC(C)(CCl)CC(C)=C1.CCOC(=O)CCc1ccc(O)c(F)c1>>CCOC(=O)CCc1ccc(OCc2c(C)cc(C)cc2C)c(F)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100286132A1,CC(C)N.Cc1onc(-c2ccc(F)cn2)c1COc1ccc(C(=O)O)nc1>>Cc1onc(-c2ccc(F)cn2)c1COc1ccc(C(=O)NC(C)C)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20080194549A1,COCCCOc1cc(C(=O)N(C[C@H]2CN(Cc3ccccc3)C[C@H]2CNC(C)C)C(C)C)ccc1OC.COCCCOc1cc(C(=O)O)ccc1OC>>COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@@H]2CN(C(=O)c2ccc(OC)c(OCCCOC)c2)C(C)C)C(C)C)ccc1OC,,O,,CC#N,CC#N,val
US20060069095A1,FC(F)(F)Oc1ccc(/C=C/c2nc(COc3ccc(CCCCc4c[nH]nn4)cc3)co2)cc1.OCCBr>>OCCn1ncc(CCCCc2ccc(OCc3coc(/C=C/c4ccc(OC(F)(F)F)cc4)n3)cc2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20100075994A1,CCOC(=O)C#CC(C)(C)O[Si](C)(C)C>>CCOC(=O)C#CC(C)(C)O,,CCOCC,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US06015829,CCOC(=O)c1cnn(-c2ccc(OCC(C)C)c(C#N)c2)c1N>>CCOC(=O)c1cnn(-c2ccc(OCC(C)C)c(C#N)c2)c1,,C1CCOC1,,CC(C)CCON=O,,val
US20110245205A1,CI.COC(=O)[C@H](C)Cc1ncc(-c2cc(C)cc(N(C(=O)OC(C)(C)C)c3nccc(C(F)(F)F)n3)c2)s1>>COC(=O)C(C)(C)Cc1ncc(-c2cc(C)cc(N(C(=O)OC(C)(C)C)c3nccc(C(F)(F)F)n3)c2)s1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20090281149A1,O=C(NCCC(O)c1cccc(C#CCCO)c1)C(F)(F)F>>NCCC(O)c1cccc(C#CCCO)c1,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US20060009453A1,Clc1nccc(-c2cccnc2Cl)n1.NCCCN1CCOCC1>>Clc1ncccc1-c1ccnc(NCCCN2CCOCC2)n1,,CCOC(C)=O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20100184761A1,CCN(CC)S(F)(F)F.CCOC(=O)CC1(O)CCN(C(=O)OC(C)(C)C)CC1>>CCOC(=O)CC1(F)CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,O=C([O-])O.[Na+],,val
US20160222028A1,COC(=O)c1ccc2c(c1)OC[C@@H](C)N(C=O)C2.NO>>C[C@@H]1COc2cc(C(=O)NO)ccc2CN1C=O,,C1CCOC1,CO,[Na+].[OH-],,val
US07737138B2,CCI.CCO.CCc1cccc(N)c1>>CCN(CC)c1ccccc1C,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20140371199A1,CC1(NC(=O)OC(C)(C)C)CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(C#N)cc5)cnc4cn3)cc2Cl)CC1>>CC1(N)CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(C#N)cc5)cnc4cn3)cc2Cl)CC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080280925A1,COC(=O)c1ccccc1CNC(=O)c1cc(C(F)(F)F)nn1-c1csc(CNC(=O)[C@H](C)NC(=O)OC(C)(C)C)c1>>COC(=O)c1ccccc1CNC(=O)c1cc(C(F)(F)F)nn1-c1csc(CNC(=O)[C@H](C)N)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090220695A1,O=S(=O)(O)O.O=S(=O)([O-])[O-].O=S(=O)([O-])[O-].[Ti+4].[Ti]>>O=S(=O)([O-])[O-].O=S(=O)([O-])[O-].[O-2].[O-2].[Ti+4].[Ti+4],,O=S(=O)(O)O,,,,val
US20030073847A1,CCc1cc(O)cc(C)c1OCCCOc1ccc(C(F)(F)F)cn1.ClCC=C(Cl)Cl>>CCc1cc(OCC=C(Cl)Cl)cc(C)c1OCCCOc1ccc(C(F)(F)F)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040048908A1,CCOC(=O)/C=C/c1cnoc1-c1ccccc1>>O=C(O)/C=C/c1cnoc1-c1ccccc1,,CC(=O)O,,Cl,,val
US20150337004A1,C=C(C)[C@@H]1CC[C@]2(C(=O)N3CCC[C@@H]3c3nc(-c4ccccc4)no3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CC1(C)CC(=O)OC(=O)C1>>C=C(C)[C@@H]1CC[C@]2(C(=O)N3CCC[C@@H]3c3nc(-c4ccccc4)no3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(=O)CC(C)(C)CC(=O)O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,CN(C)c1ccncc1,CCOC(C)=O,c1ccncc1,,,val
US20110021520A1,O=[N+]([O-])C(CO)(CO)c1cc(Br)ccc1F>>NC(CO)(CO)c1cc(Br)ccc1F,[Zn],CC(=O)O,,,,val
US20100048899A1,COC(=O)/C=C/c1c(-c2ccc(F)cc2)nc(N(C)S(C)(=O)=O)nc1C(C)C>>CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1C/C=C/O,,Cc1ccccc1,,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US04104305,Cl.NC12CCCC(C1)C1CCC2C1>>Cl.NC12CCCC(C1)C1CCC2C1,,CCOCC,,,,val
US20020132809A1,C1COCCN1.CC(=O)c1ccc(F)c(F)c1>>CC(=O)c1ccc(N2CCOCC2)c(F)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120322801A1,CC(NC(=O)OC(C)(C)C)c1ccc(C(=O)Nc2ccncc2)cc1Br.OB(O)c1cccc(O)c1>>CC(NC(=O)OC(C)(C)C)c1ccc(C(=O)Nc2ccncc2)cc1-c1cccc(O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US04681873,Nc1ccn([C@@H]2O[C@H](COC(=O)c3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@H]2OC(=O)c2ccccc2)c(=O)c1Br>>Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)c1Br,,CO,,C[O-].[Na+],,val
US07652138B2,CI.O=C(O)C(O)(c1ccc(C(F)(F)F)cc1)c1ccc(C(F)(F)F)cc1>>COC(=O)C(O)(c1ccc(C(F)(F)F)cc1)c1ccc(C(F)(F)F)cc1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US04735952,Cl.O=C(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCC(Sc2ccccc2F)CC1>>Cl.O=C(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCC(Sc2ccccc2F)CC1,,CO,,,,val
US20150284394A1,CC(C)(C)OC(=O)N1CCC(CN)CC1.CC(C)(C)c1ccc(C(=O)Cl)cc1>>CC(C)(C)OC(=O)N1CCC(CNC(=O)c2ccc(C(C)(C)C)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20060264460A1,N#Cc1cnc2ccc(N)cc2c1Nc1ccc(C(N)=O)cc1.O=Cc1cccnc1>>N#Cc1cnc2ccc(NCc3cccnc3)cc2c1Nc1ccc(C(N)=O)cc1,,C1CCOC1,CO,[BH3-]C#N.[Na+],,val
US20100273744A1,O=C(Nc1cc[nH]n1)c1c(F)cccc1F.O=[N+]([O-])c1ccc(C(F)(F)F)c(CBr)c1>>O=C(Nc1ccn(Cc2cc([N+](=O)[O-])ccc2C(F)(F)F)n1)c1c(F)cccc1F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccc(OC)c(OC)c4)nc(Cl)c3n2)cc1.COc1ccc(N)cc1OC>>COc1ccc(Nc2nc(-c3ccc(OC)c(OC)c3)nc3cn[nH]c23)cc1OC,C1COCCO1,CO,,Cl,,val
US20080234260A1,CCOC(=O)c1oc2ccc(OC)cc2c1C>>CCOC(=O)c1oc2ccc(O)cc2c1C,,ClCCl,,,,val
US20110237573A1,N#Cc1cc(Br)ccc1I.OB(O)c1ccnc(F)c1>>N#Cc1cc(Br)ccc1-c1ccnc(F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20090274655A1,COC(=O)c1sc(-c2ccc(N)cc2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C(C)C.O=C(O)c1ccncn1>>COC(=O)c1sc(-c2ccc(NC(=O)c3ccncn3)cc2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050171125A1,CC(C)Cc1cnc(N)c([N+](=O)[O-])c1>>CC(C)Cc1cnc(N)c(N)c1,[Pd],CO,,,,val
US06403809B1,O=C=O.[Li]c1cc2sc3sccc3c2s1>>O=C(O)c1cc2sc3sccc3c2s1,,O,,C1CCOC1,,val
US20150218144A1,O=C1CO[C@H](c2ccc(F)c(C(F)(F)F)c2)CN1>>Fc1ccc([C@@H]2CNCCO2)cc1C(F)(F)F,,C1CCOC1,CCOCC,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160031813A1,CCOC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1>>O=C(O)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1,,C1CCOC1,CCO,[Li+].[OH-],,val
US20070088070A1,C=C(C)c1ccc2cc(B(O)O)ccc2c1>>CC(C)c1ccc2cc(B(O)O)ccc2c1,[Pd],CO,,,,val
US20150266848A1,BrCc1ccccc1.OC/C=C/c1ccccc1Cl>>Clc1ccccc1/C=C/COCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US05332743,C1CCOC1.COc1ccccc1N1CCN(Cc2cccc(C#N)c2)CC1.Cl[Mg]C1CCCCC1>>O=C(C1CCCCC1)C1CCCCC1,,CCOCC,,,,val
US20050245530A1,Nc1ccc(Oc2ccnc(Cl)c2)c(F)c1.O=C(Cc1ccc(F)cc1)N=C=S>>O=C(Cc1ccc(F)cc1)NC(=S)Nc1ccc(Oc2ccnc(Cl)c2)c(F)c1,,ClCCl,,,,val
US20050054627A1,O=C(O)c1cncc(-c2ccccc2)c1.O=C(OO)c1cccc(Cl)c1>>O=C(O)c1cc(-c2ccccc2)c[n+]([O-])c1,,CC(Cl)Cl,,,,val
US04634713,N[C@@H]1CC[C@H](N2CCNC2=O)CC1>>N[C@@H]1CC[C@H](N2CCNC2=O)CC1,,CO,,Cl,C[O-].[Na+],val
US20130035325A1,CC(C)(C)[Si](C)(C)OCCCI.Cc1ccc(-c2c[nH]c3ncnc(N)c23)cc1>>Cc1ccc(-c2cn(CCCO[Si](C)(C)C(C)(C)C)c3ncnc(N)c23)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20040127552A1,COc1ccccc1SC[C@H](CO)OC>>COc1ccccc1SC[C@H](C=O)OC,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US05607960,CC(O)CC=Cc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1>>CC(O)CCCc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1,[Pd],O,,,,val
US03976635,CCOC(=O)C(C#N)=NOC(=O)Oc1ccc([N+](=O)[O-])cc1.O=C(O)[C@@H]1CCCN1C(=O)OCc1ccccc1>>O=C(Oc1ccc([N+](=O)[O-])cc1)[C@@H]1CCCN1C(=O)OCc1ccccc1,,CCOC(C)=O,,CCN(CC)CC,,val
US20130158075A1,COC(=O)CCCC(=O)Cl.NNC(=O)c1ccc([N+](=O)[O-])cc1>>COC(=O)CCCC(=O)NNC(=O)c1ccc([N+](=O)[O-])cc1,,ClCCl,,,,val
US20130116250A1,[H]/N=C(\CO)NC(=O)c1cccc(-c2nc(C(=O)c3ccc4[nH]c(=O)n(CCC)c(=O)c4c3)n3ccccc23)c1>>CCCn1c(=O)[nH]c2ccc(C(=O)c3nc(-c4cccc(-c5nc(C)no5)c4)c4ccccn34)cc2c1=O,,CCOCC,CN(C)C=O,,,val
US20110263562A1,CC(=O)/C=C/[C@@H]1CC[C@@H](n2cc3ccc(OCC4CC4)cc3n2)CC1>>CC(=O)CC[C@@H]1CC[C@@H](n2cc3ccc(OCC4CC4)cc3n2)CC1,,CCOC(C)=O,,,,val
US20150126490A1,CN(C[C@@H](N)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1[N+](=O)[O-].Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)O)c(F)c1>>CN(C[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1[N+](=O)[O-],,CCOC(C)=O,CN(C)C=O,ClCCCl,On1nnc2cccnc21,val
US20160264554A1,C=CC(=O)Cl.CC(C)(C)OC(=O)N(Cc1ccc(N)cc1)[C@H]1CCC[C@@H](Nc2ncc(Cl)c(-c3n[nH]c4ccccc34)n2)C1>>C=CC(=O)Nc1ccc(CN(C(=O)OC(C)(C)C)[C@H]2CCC[C@@H](Nc3ncc(Cl)c(-c4n[nH]c5ccccc45)n3)C2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20080249125A1,CCOC(=O)C(Br)c1ccccc1.COc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccc(C(F)(F)F)cc1>>CCOC(=O)C(c1ccccc1)N1CCc2c([nH]c3ccc(OC)cc23)C1CCc1ccc(C(F)(F)F)cc1,,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US20110190263A1,CC1(OC(=O)Oc2ccc([N+](=O)[O-])cc2)CC1.CO[C@H]1CNCC[C@H]1CO>>CO[C@H]1CN(C(=O)OC2(C)CC2)CC[C@H]1CO,,ClCCl,,CCN(CC)CC,Cl,val
US20090075938A1,Cc1ccc(-c2nc3cc(N)ccc3o2)cc1.O=C(O)CCC(F)(F)F>>Cc1ccc(-c2nc3cc(NC(=O)CCC(F)(F)F)ccc3o2)cc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150148349A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C(=O)O)C1.CO>>COC(=O)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)C1,,C1CCOC1,CO,C[Si](C)(C)C=[N+]=[N-],,val
US05859007,Br[Mg]c1ccccc1.CC(C)N(C(=O)CN1C(=O)C(C)(CC=O)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1>>CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)c2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1,,C1CCOC1,Cl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US04725283,NCCO.Nc1cc(Br)c([N+](=O)[O-])cc1Br>>Nc1cc(NCCO)c([N+](=O)[O-])cc1Br,,CCO,,,,val
US04640930,CN(C)CCCl.COc1ccc([C@@H]2Sc3cccc4cccc(c34)NC(=O)[C@@H]2O)cc1>>COc1ccc([C@@H]2Sc3cccc4cccc(c34)N(CCN(C)C)C(=O)[C@@H]2O)cc1,,CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100286390A1,CCN(CC)c1ccc(C(=O)Cn2ncc(N[C@@H]3C[C@@H]4C[C@H]([C@H]3C)C4(C)C)c(Br)c2=O)cc1.CCO.COc1ccc(OC)c(C(O)C(C)N)c1>>CCN(CC)c1ccc(C(Cn2ncc(N[C@@H]3C[C@@H]4C[C@H]([C@H]3C)C4(C)C)c(Br)c2=O)=NOC)cc1,,CCO,,CCOC(C)=O,Cl,val
US20150284395A1,CCOC(=O)CC(=O)c1ccc(Cl)c(OC)c1.Nc1[nH]ncc1-c1noc2ccccc12>>COc1cc(-c2cc(=O)n3ncc(-c4noc5ccccc45)c3[nH]2)ccc1Cl,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20160272651A1,CCOC(=O)CN1CCN(c2ccc(N3CCOc4ncnc(Cl)c4C3=O)cc2CC)C1=O.N>>CCOC(=O)CN1CCN(c2ccc(N3CCOc4ncnc(N)c4C3=O)cc2C)C1=O,,C1COCCO1,,,,val
US20080009512A1,CC(C)(C)OC(=O)N[C@@H](CC(=O)NC1Cc2ccccc2NC1=O)Cc1ccccc1F>>N[C@@H](CC(=O)NC1Cc2ccccc2NC1=O)Cc1ccccc1F,,C1COCCO1,,Cl,,val
US09067966B2,C=C(C)[C@@H]1CC[C@]2(C(=O)N[C@@H]3C[C@H](C(=O)N[C@H](C(=O)OC)C(C)C)C3(C)C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(C(=O)N[C@@H]3C[C@H](C(=O)N[C@H](C(=O)O)C(C)C)C3(C)C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1CCOC1,CO,[Na+].[OH-],,val
US20140296225A1,C=CCN(C(=O)OC(C)(C)C)C1CCc2ccc(C#N)cc2C1.O=[O+][O-]>>CC(C)(C)OC(=O)N(CC=O)C1CCc2ccc(C#N)cc2C1,,CO,ClCCl,c1ccncc1,,val
US04618677,CCCCCCN=C=O.ClCCl.SCCCN1CCN(CCCCc2ccc(Cl)cc2)CC1>>CCCCCCNC(O)=[SH]CCCN1CCN(CCCCc2ccc(Cl)cc2)CC1.Cl.Cl,,ClCCl,,,,val
US20050090477A1,C[C@@H]1CC2=CC(=O)CC[C@@H]2[C@H]2[C@@H](F)C[C@]3(C)C(=O)CC[C@H]3[C@H]12>>C[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)C(=O)CC[C@H]3[C@H]12,Br[Cu]Br,CC#N,CCOC(C)=O,,,val
US20090099205A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.COC(=O)[C@@H](CO)NC(=O)OC(C)(C)C>>COC(=O)[C@@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)NC(=O)OC(C)(C)C,,C1CCOC1,,c1c[nH]cn1,,val
US20100331295A1,O=S(=O)(O)c1ccc(-c2cc(C(F)(F)F)nn2-c2ccccc2Cl)s1.O=S(Cl)Cl>>O=S(=O)(Cl)c1ccc(-c2cc(C(F)(F)F)nn2-c2ccccc2Cl)s1,,CN(C)C=O,,c1ccccc1,,val
US20020156081A1,CC(C)(C)OC(=O)NC(c1ccccc1)c1ccc(Br)cc1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(C)(C)OC(=O)NC(c1ccccc1)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1,,CN(C)C=O,,ClCCl,CC(=O)[O-].[K+],val
US20130109679A1,CCOC(=O)c1ccc2cc(C(=O)OCC)n(CC3(CNC(=O)OC(C)(C)C)CCOCC3)c2c1>>CCOC(=O)c1ccc2cc(C(=O)OCC)n(CC3(CN)CCOCC3)c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080306096A1,COc1ccc2c(Cl)ncnc2c1.Cc1ccc(NC(=O)c2cc(F)cc(C(C)(C)C#N)c2)cc1N>>COc1ccc2c(Nc3cc(NC(=O)c4cc(F)cc(C(C)(C)C#N)c4)ccc3C)ncnc2c1,,CC(C)O,,,,val
US20110245257A1,Nc1cc(F)cc(F)c1.O=[N+]([O-])c1ccc(Cl)cc1F>>O=[N+]([O-])c1ccc(Cl)cc1Nc1cc(F)cc(F)c1,,CN(C)C=O,,O,CC(C)(C)[O-].[K+],val
US20080214544A1,C1CCNC1.Nc1cc(Oc2ccc(-c3cnc(Nc4ccc(F)cc4)n(Cc4ccccc4)c3=O)cc2F)ccn1.O=C(Cl)Oc1ccccc1>>O=C(Nc1cc(Oc2ccc(-c3cnc(Nc4ccc(F)cc4)n(Cc4ccccc4)c3=O)cc2F)ccn1)N1CCCC1,,C1CCOC1,,CCN(CC)CC,,val
US20100190775A1,CSc1nc(Cl)c(C(=O)NC[C@@H]2CCCN2)c(Cl)n1>>CSc1nc(Cl)c2c(n1)N1CCC[C@H]1CNC2=O,,C1COCCO1,,Cl,O=C([O-])[O-].[K+].[K+],val
US05604229,CCCCCCCCc1ccc(CCC(C(=O)OCC)C(=O)OCC)cc1.NOc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>CCCCCCCCc1ccc(CCC(N)(C(=O)OCC)C(=O)OCC)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US04731472,CCCC12CCC(=O)C=C1c1c(cc(CC(N)=O)c(Cl)c1Cl)C2>>CCCC12CCC(=O)C=C1c1c(cc(CC#N)c(Cl)c1Cl)C2,,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20120101080A1,CCC(C=O)CC(=O)OC.NCCc1ccccc1>>CCC1=CC(=O)N(CCc2ccccc2)C1,,CC(=O)O,,,,val
US20130338367A1,CC(=O)OC(C)=O.CSCCCNc1cn(-c2cccnc2)nc1Cl>>CSCCCN(C(C)=O)c1cn(-c2cccnc2)nc1Cl,,ClCCl,,O,c1ccncc1,val
US20110288097A1,CC(C)CCON=O.CC1(C)CC(=O)N(Cc2ccccc2)C(=O)C1>>CC1(C)CC(=O)N(Cc2ccccc2)C(=O)/C1=N\O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20040009995A1,CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(Br)c1.Cc1c(CO)cccc1B(O)O>>CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(-c2cc(CO)ccc2C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US04207320,CN(C)c1ccc2c(ccc3n4c(ccc5cc(C(C)(C)C)ccc54)c[n+]23)c1.[I-]>>CCc1ccc2c(ccc3c[n+]4c5ccc(N(C)C)cc5ccc4n32)c1.[I-],,CCOCC,CO,,,val
US20110237578A1,Cc1ccc(-c2cc(Br)cc(C(=O)O)c2)nc1.Cc1ncc([C@@H](C)N)cn1>>Cc1ccc(-c2cc(Br)cc(C(=O)N[C@H](C)c3cnc(C)nc3)c2)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160221945A1,O=C(NCc1cc(-c2cnc(C(F)(F)F)nc2)ncn1)[C@@H]1C[C@@H](F)CN1.O=S(=O)(Cl)c1ccc(F)cc1>>O=C(NCc1cc(-c2cnc(C(F)(F)F)nc2)ncn1)[C@@H]1C[C@@H](F)CN1S(=O)(=O)c1ccc(F)cc1,,ClCCl,,CCN(CC)CC,,val
US20110281840A1,CC(C)(C)Cc1nc2cc(S(=O)(=O)CC3CCNCC3)ccc2n1CC1CC1.Clc1ccncc1>>CC(C)(C)Cc1nc2cc(S(=O)(=O)CC3CCN(c4ccncc4)CC3)ccc2n1CC1CC1,,CCO,,CCN(CC)CC,Cl,val
US20160000760A1,N#CCCCOc1ccc(-c2c(Cl)cc([N+](=O)[O-])cc2Cl)cc1>>N#CCCCOc1ccc(-c2c(Cl)cc(N)cc2Cl)cc1,[Fe],CO,,O,[Cl-].[NH4+],val
US20120232051A1,CNc1cnccc1-c1ccccc1C.O=C(O)c1ccc(C(F)(F)F)c(C(F)(F)F)c1>>Cc1ccccc1-c1ccncc1N(C)C(=O)c1ccc(C(F)(F)F)c(C(F)(F)F)c1,,CCCCCCC,CCOC(C)=O,,,val
US20070249670A1,COC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@H](C)OC>>COC(=O)[C@@H](N)[C@H](C)OC,[Pd],CCO,,,,val
US06495555B1,Clc1noc2ccccc12.NCCCCO>>OCCCCNc1noc2ccccc12,,ClCCl,,,,val
US20040097563A1,CC(C)(C)OC(=O)c1c(-c2cccc(N)c2)cc(-c2ccccc2O)nc1N>>Nc1cccc(-c2cc(-c3ccccc3O)nc(N)c2CO)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110053959A1,CC(C)(C)OC(=O)NCCC(O)c1ccc(Cl)cc1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)NCCC(Br)c1ccc(Cl)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160068563A1,CS(=O)(=O)N1CCNCC1.O=C1C=CC2(Oc3cccc4cccc(c34)O2)c2cccc(OCc3ccoc3)c21>>O=C1C=CC2(Oc3cccc4cccc(c34)O2)c2cccc(OCc3cccnc3)c21,,C1CCOC1,,O,O=C([O-])[O-].[K+].[K+],val
US20050192347A1,CC(C)(CO)CCCCN.COC(=O)CCCN=C=O>>COC(=O)CCCNC(=O)NCCCCC(C)(C)CO,,ClCCl,,,,val
US20040082611A1,O=C1CCNCC1.O=S(=O)(Cl)c1cc2ccc(Cl)cc2s1>>O=C1CCN(S(=O)(=O)c2cc3ccc(Cl)cc3s2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130109679A1,CCOC(=O)c1ccc2cc(C(=O)OCC)n(CC3(CN)CCOCC3)c2c1>>CCOC(=O)c1ccc2cc3n(c2c1)CC1(CCOCC1)CNC3=O,,CCO,,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20050124654A1,CNC1CCOc2cc(CN3CCCCC3)ccc21.O=C(O)CC(NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1>>CN(C(=O)CC(NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1)C1CCOc2cc(CN3CCCCC3)ccc21,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20050049286A1,CC(C)=NO.Cc1cc(C)c(S(=O)(=O)Cl)c(C)c1>>CC(C)=NOS(=O)(=O)c1c(C)cc(C)cc1C,,c1ccncc1,,O,,val
US20160229814A1,CC(C)N.COC(=O)c1cc([N+](=O)[O-])ccc1F>>COC(=O)c1cc([N+](=O)[O-])ccc1NC(C)C,,CC#N,,O,,val
US20150152063A1,CC(C)(C)N.COc1ccc(F)c2c(NC(=S)NC(=O)c3ccc(F)c(F)c3)n[nH]c12>>COc1ccc(F)c2c(NC(=NC(=O)c3ccc(F)c(F)c3)NC(C)(C)C)n[nH]c12,,C1CCOC1,,ClCCCl,,val
US05880126,COCc1c(C=O)ncc2c1c1c(OCc3ccccc3)cccc1n2CC(=O)N(C)CCc1ccccc1>>COCc1c(CO)ncc2c1c1c(OCc3ccccc3)cccc1n2CC(=O)N(C)CCc1ccccc1,,C1CCOC1,,[BH4-].[Na+],,val
US20110009454A1,COCc1ccc(C(=O)O)c(N)n1.Cc1cccc(Oc2cccc(CN)c2)c1>>COCc1ccc(C(=O)NCc2cccc(Oc3cccc(C)c3)c2)c(N)n1,,CN(C)C=O,O,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US04227000,CCOC(=O)C(C=O)Cc1ccc(OC)nc1.N=C(N)N[N+](=O)[O-]>>COc1ccc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)cn1,,CO,,C[O-].[Na+],,val
US20120129851A1,CN(C)C(=O)c1ccc(NC(=O)Nc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)cc1.Cc1ccc(-c2ccc3c(N4CCOCC4)nc(Cl)nc3c2)o1>>Cc1ccc(-c2ccc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5ccc(C(=O)N(C)C)cc5)cc4)nc3c2)o1,,CCO,O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US04258045,COc1ccc(C(C#N)=CCNc2ccccc2)cc1OCc1ccccc1.N=C(N)N>>COc1ccc(Cc2cnc(N)nc2N)cc1OCc1ccccc1,,CCO,,Cl,C[O-].[Na+],val
US20030013720A1,C=CCI.CC(C)(C)OC(=O)Nc1ccc(F)c(F)c1>>C=CCN(C(=O)OC(C)(C)C)c1ccc(F)c(F)c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20120040968A1,C=O.COc1cc(NC(=O)OCc2ccccc2)ccc1C1CCNCC1>>COc1cc(NC(=O)OCc2ccccc2)ccc1C1CCN(C)CC1,,ClCCCl,O,O=C([O-])O.[Na+],,val
US07238716B2,CN(C)C=O.Cc1oc(-c2ccccc2)nc1CCC(=O)O>>Cc1oc(-c2ccccc2)nc1CCC(N)=O,,C1CCOC1,,O=C(Cl)C(=O)Cl,,val
US20080021217A1,O=C(NCc1nnc(-c2ccnc3[nH]ccc23)o1)OCc1ccccc1>>NCc1nnc(-c2ccnc3[nH]ccc23)o1,,CCO,,,,val
US06329381B1,ClCCN1CCOCC1.Nc1nc(S)nc2c1nc(O)n2Cc1ccccc1>>Nc1nc(SCCN2CCOCC2)nc2c1nc(O)n2Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090137557A1,CCCC[Sn](CCCC)(CCCC)c1cnccn1.Cc1nc(-c2ccccc2O)n(CCc2ccccc2)c(=O)c1Cl>>Cc1nc(-c2ccccc2O)n(CCc2ccccc2)c(=O)c1-c1cnccn1,,C1COCCO1,,[Cs+].[F-],,val
US20100261755A1,COC(=O)C1CCNC(c2ccc(C(F)(F)F)nc2)C1.COC(=O)Cl>>COC(=O)C1CCN(C(=O)OC)C(c2ccc(C(F)(F)F)nc2)C1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20140121187A1,CC(=O)NC12C(=O)c3ccccc3C1(O)Oc1cc(C(C)C)ccc12.CCCCC(=O)Cl>>CCCCC(=O)Oc1cc(C(C)C)ccc1C1(NC(C)=O)C(=O)c2ccccc2C1=O,,C1CCOC1,,CCN(CC)CC,,val
US20100204240A1,OCCn1cc(OCc2ccccc2)cn1>>OCCn1cc(O)cn1,[Pd],C1CCOC1,,[H][H],,val
US04260619,CC(N)Cc1ccc(O)cn1.Cl.Cl>>CC(N)Cc1ccc(O)cn1.Cl.Cl,,CCO,,,,val
US20160237095A1,COc1ccc2c(c1)CNC2.Fc1cnc(Cl)nc1Nc1ccc2[nH]ncc2c1>>COc1ccc2c(c1)CN(c1ncc(F)c(Nc3ccc4[nH]ncc4c3)n1)C2,,CC#N,,CCN(C(C)C)C(C)C,,val
US05807860,BrCCCBr.O=[N+]([O-])c1c(O)ccc2c1CCCC2>>O=[N+]([O-])c1c(OCCCBr)ccc2c1CCCC2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130195848A1,CC(C)(C)OC(=O)NCCSc1nc(-c2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12>>NCCSc1nc(-c2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160096839A1,C[C@@H]1C=CC[C@H](NC(=O)OC(C)(C)C)c2cccc(c2)-c2c(cnn2C(F)F)NC1=O>>C[C@@H]1CCC[C@H](NC(=O)OC(C)(C)C)c2cccc(c2)-c2c(cnn2C(F)F)NC1=O,O=[Pt]=O,CCO,,,,val
US20010008893A1,Cc1cc(OCc2ccccc2)c2ccccc2c1O.Cc1ccccc1N1CCNCC1.Cl.ClCC1CO1>>Cc1ccccc1N1CCN(CC(O)COc2c(C)cc(O)c3ccccc23)CC1.Cl,,CCN(CC)CC,,O=C([O-])[O-].[K+].[K+],,val
US20100267709A1,C[C@@H]1C[C@H](O)CC[C@H]1Nc1ncc(C#N)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12.OO>>C[C@@H]1C[C@H](O)CC[C@H]1Nc1ncc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130296377A1,BrC(Br)(Br)Br.Cc1ccc(S(=O)(=O)n2ccc3c(C=O)c(C)cc(C)c32)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c(C=C(Br)Br)c(C)cc(C)c32)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160046635A1,CCCNc1nc(NC)c2nc(Cl)nc(NC)c2n1>>CCCNc1nc(NC)c2ncnc(NC)c2n1,[Pd],CCO,,CCN(CC)CC,,val
US20030203900A1,CC[C@H](OC(C)(C)C)[C@H](NC(=O)OC(C)(C)C)C(=O)O>>CC[C@H](O)[C@H](N)C(=O)O,,C1COCCO1,Cl,,,val
US20140323468A1,O=C=NC(=O)c1ccccc1.c1ccc(COc2cncc(-c3cnc4c(c3)CCCN4)c2)cc1>>O=C(NC(=O)N1CCCc2cc(-c3cncc(OCc4ccccc4)c3)cnc21)c1ccccc1,,ClCCl,,,,val
US20100280033A1,COC(=O)C(C)C.Cc1ccnc(F)c1>>CC(C)C(=O)Cc1ccnc(F)c1,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US05840732,Cc1c2n(c(=O)[nH]c1=O)CCCS2.ClCCCCBr>>Cc1c2n(c(=O)n(CCCCCl)c1=O)CCCS2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110275611A1,C[C@@H]1CC[C@H](C(=O)Nc2ccccc2)CN1c1cc(-c2ccc(C#N)c(F)c2)nc(N)n1.NN>>C[C@@H]1CC[C@H](C(=O)Nc2ccccc2)CN1c1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1,,CCO,,,,val
US20090082343A1,CC(C)(C)OC(=O)CCOCCCc1cccc(C#N)n1.COC(=O)c1ccccc1S>>CC(C)(C)OC(=O)CCOCCCc1cccc(-c2nc(=O)c3ccccc3s2)n1,,Cc1ccccc1,,CCN(CC)CC,,val
US20090069288A1,CC(=O)c1ccc(O)cc1.CC1(C)OCC(CO)O1>>CC(=O)c1ccc(OCC2COC(C)(C)O2)cc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130324579A1,Cc1cccc(-c2ocnc2C(=O)Nc2cnn(CC=O)c2)c1.Cn1c(N)nc2ccccc21>>Cc1cccc(-c2ocnc2C(=O)Nc2cnn(CCNc3nc4ccccc4n3C)c2)c1,CC(=O)O,CC#N,ClCCl,,,val
US20050176689A1,COC(=O)C(C)(C)c1ccc(C#Cc2cc(OC)c3c(c2)C(C)(C)CCC3N(C)C2CC2)cc1>>COc1cc(C#Cc2ccc(C(C)(C)C(=O)O)cc2)cc2c1C(N(C)C1CC1)CCC2(C)C,,C1CCOC1,CO,Cl,[K+].[OH-],val
US20030229093A1,CI.COCCn1cccc1C(O)(c1ccc(N(C)S(=O)(=O)c2ccccc2)cc1)C(F)(F)F>>COCCn1cccc1C(OC)(c1ccc(N(C)S(=O)(=O)c2ccccc2)cc1)C(F)(F)F,,CN(C)C=O,,[H-].[Na+],,val
US05344828,C=CC(=O)OCC.c1ccc2c(c1)Cc1ccccc1C(N1CCNCC1)=N2>>CCOC(=O)CCN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1,,CCO,,,,val
US20160145247A1,CC(C)(C)OC(=O)Cc1ccccc1NC(=O)c1nc(-c2cc(F)cc(CNC(=O)OC(C)(C)C)c2)sc1Cl.CN>>CNc1sc(-c2cc(F)cc(CNC(=O)OC(C)(C)C)c2)nc1C(=O)Nc1ccccc1CC(=O)OC(C)(C)C,,CCOC(C)=O,O,CCN(C(C)C)C(C)C,CS(C)=O,val
US20090062348A1,Cc1cc2cc(I)ccc2o1.O=C1CCC(=O)N1Br>>BrCc1cc2cc(I)ccc2o1,,ClC(Cl)(Cl)Cl,,,,val
US04864021,COC(=O)c1ccc(CBr)cc1.O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](COC(c3ccccc3)(c3ccccc3)c3ccccc3)O2)cc1F>>O=C(O)c1ccc(CO[C@H]2C[C@H](n3cc(F)c(=O)[nH]c3=O)O[C@@H]2CO)cc1,,C1COCCO1,,[K+].[OH-],,val
US20090162319A1,COC(=O)c1ccc(-c2cc(C)c(O)c(C)c2)cc1.Cn1cnc2c(Cl)nc(Cl)nc21>>COC(=O)c1ccc(-c2cc(C)c(Oc3nc(Cl)nc4c3ncn4C)c(C)c2)cc1,,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20060211730A1,CC[C@]1(C(=O)OC)CCC[C@H]1NS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1.CI>>CC[C@]1(C(=O)OC)CCC[C@H]1N(C)S(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1,,C1CCOC1,,[H-].[Na+],,val
US20120270852A1,CC(C)(C)N.O=C(O)c1ncc(Br)cn1>>CC(C)(C)NC(=O)c1ncc(Br)cn1,,CN(C)C=O,ClCCl,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20110034516A1,CC1(c2ccc(CO)o2)OCCO1.CS(=O)(=O)Cl>>CC1(c2ccc(CCl)o2)OCCO1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,N#N,val
US20090326001A1,O=C(CCl)Cc1ccc(F)cc1.O=C(c1ccc(Cl)cc1)c1cccnc1S>>O=C(Cc1ccc(F)cc1)c1sc2ncccc2c1-c1ccc(Cl)cc1,,CCO,,O=C([O-])O.[Na+],,val
US04979981,CC(=O)O.C[Si](C)(C)Nc1c(Cl)cccc1Cl.O=S(=O)(Cl)c1nc2nc(CF)cc(Cl)n2n1>>COc1cc(CF)nc2nc(S(=O)(=O)Nc3c(Cl)cccc3Cl)nn12,,CC#N,ClCCl,CS(C)=O,,val
US20020045615A1,CO.O=[N+]([O-])c1cc(I)cc([N+](=O)[O-])c1>>COc1cc(I)cc([N+](=O)[O-])c1,,CO,,O,C[O-].[Na+],val
US20130245254A1,C1=COCCC1.Cc1nc(-c2nc[nH]n2)ccc1Br>>Cc1nc(-c2ncn(C3CCCCO3)n2)ccc1Br,,C1CCOC1,,CS(=O)(=O)O,,val
US20140205537A1,OC1(c2[nH]cnc2I)CCOCC1>>C1=C(c2cnc[nH]2)CCOC1,,Cl,,,,val
US20060094767A1,CC(C)(C)OC(=O)N1CCNCC1.C[C@]1(Cn2cc([N+](=O)[O-])nc2Cl)CO1>>CC(C)(C)OC(=O)N1CCN(C[C@@](C)(O)Cn2cc([N+](=O)[O-])nc2Cl)CC1,,O,,CN(C)C=O,,val
US04710508,CC(=NO)C1=CCN(C)CC1.CC(=O)Cl>>CC(=O)C1=CCNCC1,,CCN(CC)CC,,,,val
US04946858,N.O=C1OC(=O)c2cc(Cl)c(Cl)cc21>>NC(=O)c1cc(Cl)c(Cl)cc1C(=O)O,,C1CCOC1,,,,val
US05550134,CN1C(=O)CC[C@]2(C)c3ccc(S)cc3CC[C@@H]12.FC(F)(F)Oc1cccc2sc(Cl)nc12>>CN1C(=O)CC[C@]2(C)c3ccc(Sc4nc5c(OC(F)(F)F)cccc5s4)cc3CC[C@@H]12,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04576954,CNCCc1ccccc1.O=c1ssc(Cl)c1Cl>>CN(CCc1ccccc1)c1ssc(=O)c1Cl,,CO,,O=C([O-])O.[K+],,val
US04061656,Cc1sc(C=O)c(C)c1C>>Cc1sc(CO)c(C)c1C,,CCO,,[BH4-].[Na+],,val
US20030105099A1,CC[C@H](NC(=O)C(CC(=O)N1CCOCC1)CS(=O)(=O)CC(C)C)C(O)c1noc(-c2ccccc2)n1>>CC[C@H](NC(=O)C(CC(=O)N1CCOCC1)CS(=O)(=O)CC(C)C)C(=O)c1noc(-c2ccccc2)n1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20030087926A1,C=Cc1ccccc1.CCC(=O)C(=O)[O-].Nc1cc(Cl)cc(Cl)c1>>O=C(O)C1CC(c2ccccc2)c2c(Cl)cc(Cl)cc2N1,,CC#N,CCO,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20030130517A1,CC(C)(C)OC(=O)COc1ccc(-c2c(Cl)c(CN3C(=O)CCC3=O)nc3sc4c(c23)CCSC4)cc1.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)COc1ccc(-c2c(Cl)c(CN3C(=O)CCC3=O)nc3sc4c(c23)CCS(=O)C4)cc1,,ClCCl,,,,val
US06617124B1,CN.COc1ccc2c(CBr)cc(=O)oc2c1>>CNCc1cc(=O)oc2cc(OC)ccc12,,C1CCOC1,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20070124152A1,CCOC(=O)CC(=O)Cl.CCOC(=O)c1ncc(Cc2ccc(F)cc2)cc1Nc1ccc(F)cc1>>CCOC(=O)CC(=O)N(c1ccc(F)cc1)c1cc(Cc2ccc(F)cc2)cnc1C(=O)OCC,,ClCCCl,,CO,ClCCl,val
US20080096882A1,COC[C@H](N)c1nc2ccc(Cl)cc2[nH]1.O=S1CCc2nc(N3CCN(c4ccc(Cl)cc4)CC3)nc(Cl)c21>>COC[C@H](Nc1nc(N2CCN(c3ccc(Cl)cc3)CC2)nc2c1S(=O)CC2)c1nc2ccc(Cl)cc2[nH]1,,C1COCCO1,ClCCl,CCN(C(C)C)C(C)C,O,val
US20040197358A1,CCCCC/C=C/CCCCCCC1OCCO1>>CCCCC/C=C/CCCCCCC=O,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20100305096A1,CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1.FC1CN(C2CCNCC2)C1>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(N4CC(F)C4)CC3)n(C)c2n1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20050059673A1,COc1cccc2c(CCI)coc12.c1cnc2c(N3CCNCC3)cccc2c1>>COc1cccc2c(CCN3CCN(c4cccc5cccnc45)CC3)coc12,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US05563163,COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(CCl)C2=O.O=C(O)c1ccsc1>>COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC(=O)c1ccsc1)C2=O,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20080194536A1,CC(C)(C)[C@](C)(C(=O)[O-])N(CC(F)(F)F)c1ccc(C#N)c(C(F)(F)F)c1>>C[C@@H](C(=O)O)N(CC(F)(F)F)c1ccc(C#N)c(C(F)(F)F)c1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20040034104A1,CC(=O)OCCBr.CN(C)C(=O)C(CCN1CCN(c2ccccc2O)CC1)(c1ccccc1)c1ccccc1>>CC(=O)OCCOc1ccccc1N1CCN(CCC(C(=O)N(C)C)(c2ccccc2)c2ccccc2)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100137317A1,COc1ccc(-c2c(-c3ccc(OC)cc3)n(C)c(=O)n2C)cc1>>COc1ccc(-c2c(-c3ccc(O)cc3)n(C)c(=O)n2C)cc1,,ClCCl,,BrB(Br)Br,,val
US20110003822A1,Cc1ccc(-c2cc(/C=N/O)cc(C(=O)N[C@H](C)c3ccc(F)cn3)c2)nc1.O=C1CCC(=O)N1Cl>>Cc1ccc(-c2cc(C(=O)N[C@H](C)c3ccc(F)cn3)cc(C(Cl)=NO)c2)nc1,,O,,,,val
US20060094767A1,C[C@](O)(COC(=O)N1CCCc2cc(Cl)ccc21)Cn1cc([N+](=O)[O-])nc1Cl>>C[C@]1(COC(=O)N2CCCc3cc(Cl)ccc32)Cn2cc([N+](=O)[O-])nc2O1,,CN(C)C=O,,[H-].[Na+],,val
US06448236B1,CCCS(=O)(=O)Cl.CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CN)nc32)[C@@H]2OC(C)(C)O[C@@H]21>>CCCS(=O)(=O)NCc1nc(NCC(c2ccccc2)c2ccccc2)c2ncn([C@@H]3O[C@](CC)(C(N)=O)[C@@H](O)[C@H]3O)c2n1,,ClCCl,,CCN(CC)CC,,val
US20130310394A1,Cc1cc(N)ccc1C1CN=C2c3ccccc3NC(=O)N2C1.Cc1cccc(N=C=O)c1>>Cc1cccc(NC(=O)Nc2ccc(C3CN=C4c5ccccc5NC(=O)N4C3)c(C)c2)c1,,ClCCl,,CCN(CC)CC,,val
US04539324,Cc1ccccc1COCCl.O=c1ncc(Cl)c[nH]1>>Cc1ccccc1COCn1cc(Cl)cnc1=O,,ClCCl,,CCN(CC)CC,Cl,val
US20160168137A1,ClC(Cl)(Cl)C(Cl)(Cl)Cl.c1ccc2c(-c3cnco3)cccc2c1>>Clc1ncc(-c2cccc3ccccc23)o1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US04299821,CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1C(=O)OCc1ccccc1>>CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1,[Pd],O,,,,val
US20120316366A1,CCOP(=O)(CC=C(C)CCC=C(C)C)OCC.COC(OC)C(C)C=O>>COC(OC)C(C)C=CC=C(C)CCC=C(C)C,,C1CCOC1,CCOCC,O,CC(C)(C)[O-].[K+],val
US04824834,OO.Oc1nc(S)nc2c(-c3ccccc3)cnn12>>Oc1nc(O)n2ncc(-c3ccccc3)c2n1,,CO,,Cl,[Na+].[OH-],val
US20150087646A1,Cc1ccc(-n2nc(-c3cc(CNC(=O)C(F)(F)F)ccc3Cl)[nH]c2=O)cc1Cl>>Cc1ccc(-n2nc(-c3cc(CN)ccc3Cl)[nH]c2=O)cc1Cl,,C1CCOC1,,O,[K+].[OH-],val
US20100113440A1,C=CC1CC1(NC(=O)C1CC(Oc2cc(-c3ccccc3)nc(OC)n2)CC1C(=O)OC(C)(C)C)C(=O)OCC>>C=CC1CC1(NC(=O)C1CC(Oc2cc(-c3ccccc3)nc(OC)n2)CC1C(=O)O)C(=O)OCC,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US04812164,CC(C)OC(=O)c1cc(-n2c(Cl)nc(C(F)(F)C(F)(F)F)cc2=O)c(F)cc1Cl.CCO>>CCc1nc(C(F)(F)C(F)(F)F)cc(=O)n1-c1cc(C(=O)OC(C)C)c(Cl)cc1F,,CCO,,C,C[O-].[Na+],val
US20080146565A1,COc1cccc(C(=O)c2ccnc(SC)n2)c1F.NO>>COc1cccc2c(-c3ccnc(SC)n3)noc12,,CCO,CCOC(C)=O,C1CCC2=NCCCN2CC1,,val
US20030186987A1,CS(=O)(=O)O.Clc1ncnc2cccnc12.Nc1ccccc1>>CS(=O)(=O)O.c1ccc(Nc2ncnc3cccnc23)cc1,,CCO,,CCN(CC)CC,,val
US20110144105A1,O=S(=O)(Cl)c1ccccc1.O=[N+]([O-])c1cnc2[nH]ccc2c1>>O=[N+]([O-])c1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1,CN(C)c1ccncc1,CN(C)C=O,ClCCl,CCN(CC)CC,,val
US20150141400A1,CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(C=O)c(OC(F)(F)F)cc2c1=O.CN(C(=O)OC(C)(C)C)[C@@H]1CCCNC1>>CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(CN3CCC[C@@H](N(C)C(=O)OC(C)(C)C)C3)c(OC(F)(F)F)cc2c1=O,,ClCCl,,,,val
US05536721,COCCOCCl.O=Cc1c(Cl)[nH]c2ccccc12>>COCCOCn1c(Cl)c(C=O)c2ccccc21,,C1CCOC1,,[H-].[Na+],O=C([O-])[O-].[K+].[K+],val
US20050282820A1,CC(C)(C)c1ccccc1C(=O)Cl.Nc1ccccc1Br>>CC(C)(C)c1ccc(C(=O)Nc2ccccc2Br)cc1,,C1CCOC1,,O,O=C([O-])O.[Na+],val
US20040142922A1,O=S(=O)(c1ccc2c(c1)OC(c1ccccc1)(c1ccccc1)O2)N1CC=C(c2ccc(F)cc2)CC1>>O=S(=O)(c1ccc(O)c(O)c1)N1CC=C(c2ccc(F)cc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040044052A1,O=[N+]([O-])O.O=c1[nH]c2c(F)cccc2o1>>O=c1[nH]c2c(F)cc([N+](=O)[O-])cc2o1,,O=S(=O)(O)O,,,,val
US20080214654A1,COc1cc(CNCc2ccccc2)ccc1OCc1ccc(F)cc1.O=C(Cl)c1ccccc1>>COc1cc(CN(Cc2ccccc2)C(=O)c2ccccc2)ccc1OCc1ccc(F)cc1,,ClCCl,,CCN(CC)CC,[Na+].[OH-],val
US20080221136A1,COCCCl.O=Cc1cccc(O)c1O>>COCCOc1c(O)cccc1C=O,,CN(C)C=O,,[I-].[K+],,val
US20140010783A1,N#C[Cu].Nc1c(Cl)cc([N+](=O)[O-])cc1Cl>>N#Cc1c(Cl)cc([N+](=O)[O-])cc1Cl,,CS(C)=O,,CC(C)(C)ON=O,,val
US20150307443A1,CI.O=C(Nc1cccc(Cl)c1)c1cccc2c1OCCO2>>CN(C(=O)c1cccc2c1OCCO2)c1cccc(Cl)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20070232607A1,C=O.O=C(COc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)N1CCNCC1>>CN1CCN(C(=O)COc2cccc3ncnc(Nc4ccc(OCc5ccccn5)c(Cl)c4)c23)CC1,,CS(C)=O,,O=CO,,val
US20130158031A1,C[Si](C)(C)C#Cc1ccc(-n2cncc2-c2ccncc2)cc1>>C#Cc1ccc(-n2cncc2-c2ccncc2)cc1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20020198195A1,CC(C)(C)OC(=O)NCC1CCN(c2ccnc(O)c2)CC1>>NCC1CCN(c2ccnc(O)c2)CC1,,ClCCl,,Cc1ccccc1,,val
US05846989,COC(=O)CCS(=O)(=O)Cl.NCCOCCc1ccc(F)cc1>>COC(=O)CCS(=O)(=O)NCCOCCc1ccc(F)cc1,,CCOCC,,CCN(CC)CC,,val
US20030203889A1,O=C(CBr)c1ccc(F)cc1.O=S(=O)(c1ccc(Br)cc1)C1CCNCC1>>O=C(CN1CCC(S(=O)(=O)c2ccc(Br)cc2)CC1)c1ccc(F)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05006555,O=C1CCC(=O)O1.Oc1c(Cc2ccccc2)ccc2ccccc12>>O=C(O)CCC(=O)Oc1c(Cc2ccccc2)ccc2ccccc12,,C1CCOC1,CCCCCC,Cl,[H-].[Na+],val
US05310634,CCI.CCN(CC)C(C)=O.COC(=O)Nc1cccc(N)c1>>CCN(CC)c1cccc(NC(=O)OC)c1,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US05719141,C=CCC[C@H](O)[C@H](CC(C)(C)CCO[Si](C(C)C)(C(C)C)C(C)C)NC(=O)OC(C)(C)C.COC(C)(C)OC>>C=CCC[C@@H]1OC(C)(C)N(C(=O)OC(C)(C)C)[C@H]1CC(C)(C)CCO[Si](C(C)C)(C(C)C)C(C)C,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120302540A1,CC(C)(C)OC(=O)N1CCCC2(C1)C(=O)NCN2c1ccccc1.CI>>CN1CN(c2ccccc2)C2(CCCN(C(=O)OC(C)(C)C)C2)C1=O,,C1CCOC1,CCOC(C)=O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100190831A1,CCOC(=O)/C=C/c1cc(F)c(O)c(F)c1>>CCOC(=O)CCc1cc(F)c(O)c(F)c1,[Pd],CCO,,[H][H],,val
US20120238574A1,CNC1CCN(Cc2ccccc2)CC1.O=[N+]([O-])c1ccc(F)cc1>>CN(c1ccc([N+](=O)[O-])cc1)C1CCN(Cc2ccccc2)CC1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20150126490A1,C=C[C@@H](NC(=O)OC(C)(C)C)c1cc(F)cc(I)c1.CO>>CC(C)(C)OC(=O)N[C@H](CO)c1cc(F)cc(I)c1,,CC(C)=O,ClCCl,[BH4-].[Na+],[Cl-].[NH4+],val
US20030134853A1,N#Cc1ccc(NC2CCCCC2)c([N+](=O)[O-])c1>>N#Cc1ccc(NC2CCCCC2)c(N)c1,[Pd],CCOC(C)=O,CO,,,val
US06107297,Cc1ccc2c(c1)CCc1cc(C)ccc1C2=O>>Cc1ccc2c(c1)CCc1cc(C)ccc1C2O,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20020055046A1,CCCCCCCCCCCCCCCC1=C(c2cn(C)c3ccccc23)C(=O)N(C)C1=O.ClCCl.O=C(Cl)c1ccccc1>>COC1=C(c2cn(C)c3ccccc23)C(=O)N(C)C1=O,,O,,[Na+].[OH-],,val
US20160083387A1,C=C1CC[C@H]2[C@H](OC(C)=O)[C@@H]([C@@]3(C)CC[C@H](OC(C)=O)C[C@@H]3CCO)CC[C@]12C.Cc1ccc(S(=O)(=O)Cl)cc1>>C=C1CC[C@H]2[C@H](OC(C)=O)[C@@H]([C@@]3(C)CC[C@H](OC(C)=O)C[C@@H]3CCOS(=O)(=O)c3ccc(C)cc3)CC[C@]12C,CN(C)c1ccncc1,c1ccncc1,,,,val
US20160264567A1,CCCC[Sn](CCCC)(CCCC)c1cnc(C(F)(F)F)s1.O=C1c2ccccc2C(=O)N1Cc1cc(Cl)ncc1Cl>>O=C1c2ccccc2C(=O)N1Cc1cc(-c2cnc(C(F)(F)F)s2)ncc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CN(C)C=O,,,val
US20120041009A1,NC(=NO)c1cc(-c2ccccc2)nc(C2CC2)n1.O=C(n1ccnc1)n1ccnc1>>O=c1nc(-c2cc(-c3ccccc3)nc(C3CC3)n2)[nH]o1,,C1CCOC1,O,C1CCC2=NCCCN2CC1,Cl,val
US20080249112A1,CC(C)C(O)c1nc2n(c(=O)c1Cc1ccccc1)CCCC2.O=C1NC(=O)c2ccccc21>>CC(C)C(c1nc2n(c(=O)c1Cc1ccccc1)CCCC2)N1C(=O)c2ccccc2C1=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110028467A1,Cl.O=C(c1cc(Br)c(O)c(Br)c1)N1CCOc2ccncc21>>Cl.O=C(c1cc(Br)c(O)c(Br)c1)N1CCOc2ccncc21,,C1CCOC1,,C1COCCO1,,val
US20100016343A1,N#CCCCN1CCCCC1>>NCCCCN1CCCCC1,[Ni],CO,O,[NH4+].[OH-],,val
US20110053940A1,CC(C)(C)OC(=O)N(Cc1cc(CCO)cc(Cl)c1Cl)C1CC1.CI>>COCCc1cc(Cl)c(Cl)c(CN(C(=O)OC(C)(C)C)C2CC2)c1,,C1CCOC1,,[H-].[Na+],,val
US20100009991A1,CC(C)(C)OC(=O)CN1CCc2c(C(=O)NCCn3cc(C(c4ccccc4)c4ccccc4)ccc3=O)cccc21>>O=C(O)CN1CCc2c(C(=O)NCCn3cc(C(c4ccccc4)c4ccccc4)ccc3=O)cccc21,,O=C(O)C(F)(F)F,,,,val
US20150183802A1,N#Cc1cc2cncc(O)c2cc1F.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>N#Cc1cc2cncc(OS(=O)(=O)C(F)(F)F)c2cc1F,CN(C)c1ccncc1,O,c1ccncc1,,,val
US20050288346A1,CCCC(=O)c1ccc(OCCCCOc2ccc(C#N)cc2)c(C)c1O.C[Si](C)(C)N=[N+]=[N-]>>CCCC(=O)c1ccc(OCCCCOc2ccc(-c3nn[nH]n3)cc2)c(C)c1O,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US20080269219A1,CCc1ncc[nH]1.Cc1ccccc1OCCCc1oc(Cl)nc1-c1ccc(Cl)cc1>>CCc1nccn1-c1nc(-c2ccc(Cl)cc2)c(CCCOc2ccccc2C)o1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20040006067A1,Cc1cc(C)c(S(=O)(=O)Nc2ccccc2C2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@@H]3Cc4ccccc4CN3C(=O)OC(C)(C)C)CC2)c(C)c1>>Cc1cc(C)c(S(=O)(=O)Nc2ccccc2C2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@@H]3Cc4ccccc4CN3)CC2)c(C)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050131068A1,CCCCNCc1ccc(C(F)(F)F)cc1F.CCOC(=O)[C@H](Cc1ccc(OCC(=O)O)cc1)OCC>>CCCCN(Cc1ccc(C(F)(F)F)cc1F)C(=O)COc1ccc(C[C@H](OCC)C(=O)OCC)cc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20030225057A1,C=CCOc1cc2c(cc1I)C(C)CN(C(=O)C(F)(F)F)CC2>>C=CCOc1cc2c(cc1I)C(C)CNCC2,,CO,O,[Na+].[OH-],,val
US20100041711A1,C[C@@H]1CC[C@@H](N(CCc2ccccc2)C(=O)Nc2ncc(SC(C)(C)C(=O)O)s2)CC1.N#CCCBr>>C[C@@H]1CC[C@@H](N(CCC#N)C(=O)Nc2ncc(SCC(=O)O)s2)CC1,,CCOC(C)=O,,,,val
US20140005132A1,C#Cc1ccc(OC)cc1.COCO[C@H]1C[C@H]2OC(C)(C)OC[C@]23C2C(CC[C@]3(O)C1)[C@@]1(OCOC)CC[C@H](CN=[N+]=[N-])[C@@]1(C)C[C@H]2OCOC>>COCO[C@H]1C[C@H]2OC(C)(C)OC[C@]23C2C(CC[C@]3(O)C1)[C@@]1(OCOC)CC[C@H](Cn3cc(-c4ccc(OC)cc4)nn3)[C@@]1(C)C[C@H]2OCOC,,CN(C)C=O,O,O=C(CO)O[CH][C@@H](O)CO,C[O-].[Na+],val
US06686353B1,C1CNCCN1.N#Cc1ccc(CBr)cc1>>N#Cc1ccc(CN2CCNCC2)cc1,,CCO,,Cl,,val
US04352815,CNCC(=O)O.O=c1[nH]c2cccc(I)c2c(=O)o1>>CN1CC(=O)Nc2cccc(I)c2C1=O,,CC(=O)N(C)C,,,,val
US20100144700A1,CCOC(=O)C1CN(C(=O)OC(C)(C)C)CCC1=O.C[C@@H](N)c1ccccc1>>CCOC(=O)C1=C(NC(C)c2ccccc2)CCN(C(=O)OC(C)(C)C)C1,,Cc1ccccc1,,O,,val
US20090131444A1,CC(C)(C)OC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@@H]1CO>>CC(C)(C)OC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@@H]1C=O,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20080269220A1,CCOCCSc1cc(C)c(-c2cccc(C=O)c2)c(C)c1>>CCOCCSc1cc(C)c(-c2cccc(CO)c2)c(C)c1,,C1CCOC1,CO,[BH4-].[Na+],,val
US05998452,BrCCCBr.CC(C)(C)c1cc(-c2n[nH]c(=O)o2)cc(C(C)(C)C)c1O>>CC(C)(C)c1cc(-c2nn(CCCBr)c(=O)o2)cc(C(C)(C)C)c1O,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20130331374A1,O=[N+]([O-])c1ccc(OCCO)c(-n2nnnc2C2CC2)c1>>Nc1ccc(OCCO)c(-n2nnnc2C2CC2)c1,[Pd],CO,,,,val
US05374638,C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)OC)c1ccccc1>>C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1,,CO,,Cl,[Na+].[OH-],val
US05476944,C1CC2OC2C1.CC(C)(C)c1ccc(O)c(C(C)(C)C)c1>>CC(C)(C)c1ccc(O[C@@H]2CCC[C@H]2O)c(C(C)(C)C)c1,,CCO,,C,C[O-].[Na+],val
US20110124637A1,C1COCCN1.O=Cc1ccc(F)cc1C(F)F>>O=Cc1ccc(N2CCOCC2)cc1C(F)F,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20080319005A1,CCOC(=O)C(=O)c1ccc([N+](=O)[O-])cc1>>CCOC(=O)C(=O)c1ccc(N)cc1,[Pd],CCO,,,,val
US20140350011A1,COc1cc(CN2CCNCC2)ccc1-c1nc2c(N[C@@H]3[C@H]4C=C[C@H](C4)[C@@H]3C(N)=O)c(Cl)cnc2[nH]1.C[C@H]1CO1>>COc1cc(CN2CCN(C[C@H](C)O)CC2)ccc1-c1nc2c(N[C@@H]3[C@H]4C=C[C@H](C4)[C@@H]3C(N)=O)c(Cl)cnc2[nH]1,,CO,,,,val
US04478841,CC(Cc1c[nH]c2ccccc12)c1ccncc1>>CC(Cc1c[nH]c2ccccc12)C1CCNCC1,O=[Pt],CC(=O)O,,,,val
US20130029971A1,BrC(Br)(Br)Br.CS(=O)(=O)c1cnc(N2CCC(CCO)CC2)c(NC(=O)c2cccc(Cl)c2)c1>>CS(=O)(=O)c1cnc(N2CCC(CCBr)CC2)c(NC(=O)c2cccc(Cl)c2)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20140128371A1,C/C(=N\O)c1cc2c(c(F)c1F)N1C[C@@H](C)O[C@@H](C)[C@@H]1C1(C2)C(=O)NC(=O)NC1=O>>Cc1noc2c(F)c3c(cc12)CC1(C(=O)NC(=O)NC1=O)[C@H]1[C@H](C)O[C@H](C)CN31,,CS(C)=O,,,,val
US20110301143A1,CCOC(=O)Cn1nnc(-c2cnc(N3CC(C(=O)c4ccccc4C(F)(F)F)C3)s2)n1>>O=C(O)Cn1nnc(-c2cnc(N3CC(C(=O)c4ccccc4C(F)(F)F)C3)s2)n1,,C1CCOC1,,CC(=O)O,[Li+].[OH-],val
US20060235031A1,C=C1CC(c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(Cl)nccn23)C1.OO>>OCC1CC(c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(Cl)nccn23)C1,,C1CCOC1,ClCCl,B1C2CCCC1CCC2,[Na+].[OH-],val
US20130261111A1,C=CCN(CC(=NO)c1ccccc1)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CC2CONC2(c2ccccc2)C1,,Cc1ccccc1C,,,,val
US20060040941A1,CCOC(=O)C(=O)C(CC)NC(C)=O.N=C(N)c1ccccc1.NN>>CCC(NC(C)=O)c1nnc(-c2ccccc2)[nH]c1=O,,CCO,,Cl,O,val
US06288061B1,CC(=O)NCc1ccc(CCl)cc1.CNC>>CC(=O)NCc1ccc(CN(C)C)cc1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US03954438,CCNc1cc(OC)c(C(F)(F)F)cc1[N+](=O)[O-].CCOC(C)=O>>CCn1c(C)nc2cc(C(F)(F)F)c(OC)cc21,O=[Pt],CCO,,,,val
US20150353499A1,CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H]1CCc2ccccc2NC1=O.COc1ccc2cc(Br)ccc2c1CCl>>COc1ccc2cc(Br)ccc2c1CN1C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)OC(C)(C)C)CCc2ccccc21,,CN(C)C=O,O,[I-].[Na+],O=C([O-])[O-].[Cs+].[Cs+],val
US20160257668A1,CC(C)(C)OC(=O)c1ccc(NC(=O)c2ncc(Cl)cc2OC2CCN(C(=O)OC(C)(C)C)CC2)cc1.OB(O)c1ccccc1>>CC(C)(C)OC(=O)c1ccc(NC(=O)c2ncc(-c3ccccc3)cc2OC2CCN(C(=O)OC(C)(C)C)CC2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US04600429,NCCCCCCCCCN.O.O=P(O)(O)CCl>>NCCCCCCCCCNCP(=O)(O)O.O,,O,,,,val
US20140357642A1,CCc1cnc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc2c1>>CCC1CNc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc2C1,[Pd],CCO,,O=C([O-])O.[Na+],,val
US20020160996A1,BrP(Br)Br.CC(=Cc1ccc(C(C)C)cc1)CO>>CC(=Cc1ccc(C(C)C)cc1)CBr,,CC(C)OC(C)C,,O,,val
US06444833B1,CCOC(=O)C(C)P(=O)(OCC)OCC.O=Cc1cccn1-c1ccccc1>>CCOC(=O)/C(C)=C\c1cccn1-c1ccccc1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20160145271A1,Cc1ccc2c(-c3nnc4c(n3)NC(=O)C43CC3)nn(COCC[Si](C)(C)C)c2n1>>Cc1ccc2c(-c3nnc4c(n3)NC(=O)C43CC3)n[nH]c2n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100068197A1,C1CNCCN1.COc1ccc(N(C)c2nc(Cl)nc3ccccc23)cc1>>COc1ccc(N(C)c2nc(N3CCNCC3)nc3ccccc23)cc1,,CCCCO,,Cl,,val
US20040192686A1,CNCCN(C)C.[O-][n+]1nc(Cl)nc2ccccc21>>CN(C)CCN(C)c1nc2ccccc2[n+]([O-])n1,,COCCOC,,,,val
US20090156643A1,NCC(F)(F)F.NCc1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1.O=C(n1ccnc1)n1ccnc1>>O=C(NCc1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1)NCC(F)(F)F,,C1CCOC1,CCOC(C)=O,,,val
US20100056530A1,COC(=O)c1cnc2sc(Nc3ncc(Br)cc3OCc3ccccc3)nc2c1>>O=C(O)c1cnc2sc(Nc3ncc(Br)cc3OCc3ccccc3)nc2c1,,CCO,,[Na+].[OH-],,val
US20030166628A1,CN(C)C(=S)Cl.COc1cccc(C=O)c1O>>COc1cccc(C=O)c1OC(=S)N(C)C,,C1CCOC1,O,[K+].[OH-],,val
US05696267,CC(C)(C)[Si](C)(C)OCC(O)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1>>CC(C)(C)[Si](C)(C)OCC(=O)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20100286118A1,CC(C)(C)OC(=O)NC1(C(=O)N[C@@H](Cc2ccc(I)cc2)C(N)=O)CCOCC1.COCCCn1c(=O)oc2ccc(B3OC(C)(C)C(C)(C)O3)cc21>>COCCCn1c(=O)oc2ccc(-c3ccc(C[C@H](NC(=O)C4(NC(=O)OC(C)(C)C)CCOCC4)C(N)=O)cc3)cc21,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20070135367A1,C1CCNCC1.Cc1ccc(Cl)c([N+](=O)[O-])c1>>Cc1ccc(N2CCCCC2)c([N+](=O)[O-])c1,,O,,CN(C)C=O,,val
US20010051620A1,COc1ccc2cc3ncc(C#N)c(Cl)c3cc2c1.Nc1ccc(Cl)cc1Cl>>COc1ccc2cc3ncc(C#N)c(Nc4ccc(Cl)cc4Cl)c3cc2c1,,CN(C)C=O,,[H-].[Na+],,val
US04748186,FC(F)=C(F)CCBr.Nc1nnc(C(F)(F)F)s1.S=C=S>>FC(F)=C(F)CCSC(=S)Nc1nnc(C(F)(F)F)s1,,CS(C)=O,,,,val
US20140045872A1,C[N+](=O)[O-].O=Cc1ccc(F)c(Cl)c1>>O=[N+]([O-])C=Cc1ccc(F)c(Cl)c1,,CCO,,[Na+].[OH-],,val
US20140296136A1,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)O[C@@H]1CCC[C@H]1CCC=CCc1c(nc3ccccc3c1O)O2)C(=O)NS(=O)(=O)C1CC1.CC(=O)OC(C)=O>>C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)O[C@@H]1CCC[C@H]1CCC=CCc1c(nc3ccccc3c1OC(C)=O)O2)C(=O)NS(=O)(=O)C1CC1,,c1ccncc1,,,,val
US05849753,CCCCc1nc2nc(CO)c(Br)cc2[nH]1>>CCCCc1nc2nc(CO)ccc2[nH]1,[Pd],CCO,,[H][H],,val
US04921950,COC(=O)OC[C@H]1O[C@@H](n2cc(C)c(=O)[nH]c2=O)C[C@H]1OS(C)(=O)=O.[N-]=[N+]=[N-]>>COC(=O)OC[C@H]1O[C@@H](n2cc(C)c(=O)[nH]c2=O)C[C@@H]1N=[N+]=[N-],,CN(C)C=O,,O,,val
US20080280855A1,Cc1ccccc1C(=O)CCc1c(C(=O)N(C)C)cc2c(nc(C)n2C)c1O>>Cc1ccccc1[C@H](O)CCc1c(C(=O)N(C)C)cc2c(nc(C)n2C)c1O,,CC(C)O,,CC(C)(C)[O-].[K+],,val
US20150119411A1,COCCCN.O=C(O)c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1>>COCCCNC(=O)c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050043309A1,CC(=O)OC(C)(C)C.CC(=O)c1ccc(Cl)nc1NC(=O)C(C)(C)C>>CC(C)(C)OC(=O)CC(C)(O)c1ccc(Cl)nc1NC(=O)C(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20090124802A1,Cc1cc([N+](=O)[O-])cc(C)c1O.Clc1nc(Cl)c2c(ccn2Cc2ccccc2)n1>>Cc1cc([N+](=O)[O-])cc(C)c1Oc1nc(Cl)nc2ccn(Cc3ccccc3)c12,,CN1CCCC1=O,O,[H-].[Na+],,val
US20090069288A1,CCOC(=O)c1cc(-c2ccc(OC(C)C)c(Cl)c2)on1>>CC(C)Oc1ccc(-c2cc(C(=O)O)no2)cc1Cl,,C1CCOC1,,[Na+].[OH-],,val
US20070287706A1,CN1CCOc2cc(S(=O)(=O)Cl)ccc21.Cc1cccc2cc(CN[C@@H]3CCC[C@H]3O)c(=O)[nH]c12>>Cc1cccc2cc(CN([C@@H]3CCC[C@H]3O)S(=O)(=O)c3ccc4c(c3)OCCN4C)c(=O)[nH]c12.Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070219196A1,CCOC(=O)CCCCCNc1c(N)cnc2ccccc12.CCOC(OCC)OCC>>CCOC(=O)CCCCCn1cnc2cnc3ccccc3c21,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20080176827A1,CCOC(=O)c1cc(C#N)c(Cl)nc1CC.O=C(O)C1CNC1>>CCOC(=O)c1cc(C#N)c(N2CC(C(=O)O)C2)nc1CC,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US04775674,CC(=O)OCCOc1ccc([N+](=O)[O-])c(C=C2NC(=O)NC2=O)c1>>CC(=O)OCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1,,CC#N,,II,,val
US20130059834A1,CC(C)(CO)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-n3nc(C4CCN(C(=O)OC(C)(C)C)CC4)c4ccccc43)nc12>>CC(C)(CO)NC(=O)c1c[nH]c2ncc(-n3nc(C4CCNCC4)c4ccccc43)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120214802A1,CC(=O)Cl.CO.O=C(O)[C@H]1C[C@@H](O)CN1>>COC(=O)[C@H]1C[C@@H](O)CN1.Cl,,CCOCC,,,,val
US20080045554A1,CCCCCn1/c(=N/N=C\CCNC(=O)OCc2ccccc2)[nH]c(=O)c2[nH]cnc21>>CCCCCn1c2nc[nH]c2c(=O)n2c(CCNC(=O)OCc3ccccc3)nnc12,,CC(=O)O,,,,val
US20070032485A1,CCOC(=O)CCCBr.CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(O)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC>>CCOC(=O)CCCOc1cnc(N[C@H]2C[C@@H](CC)N(C(=O)OCC)c3ccc(OC)nc32)nc1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05208250,O=C1CNC(=S)N1.O=Cc1ccc(O)c(Br)c1>>O=C1NC(=S)NC1=Cc1ccc(O)c(Br)c1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20050090432A1,CCNCC.COc1ccc(C(=O)Cl)c(C)c1>>c1ccc2cnccc2c1,,ClCCl,,,,val
US20140350011A1,NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc(N)c2[N+](=O)[O-])[C@H]2CC[C@@H]1O2>>NC(=O)C1C2CCC(O2)C1Nc1c(Cl)cnc(N)c1N,[Ni],,,,,val
US20120142717A1,COC(=O)CCc1cnn(C)c1.COC=O>>COC(=O)C(C=O)Cc1cnn(C)c1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20060063746A1,CC(=O)OCC(=O)[C@@]1(OC(=O)N[C@H](C)c2ccccc2)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C>>C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)N[C@H](C)c1ccccc1)C(=O)CO,,CO,ClC(Cl)Cl,,,val
US20150025093A1,CC(C)(C)OC(=O)NC1CCC(O)CC1.CC(C)c1cc2c(Cl)ncnc2s1>>CC(C)c1cc2c(OC3CCC(NC(=O)OC(C)(C)C)CC3)ncnc2s1,,C1CCOC1,,[H-].[Na+],,val
US20090258936A1,CC(C)(C)OC(=O)C(C)(C)NC(=O)c1ccc2sccc2c1OCCOc1ccccc1.O=C(O)C(F)(F)F>>CC(C)(NC(=O)c1ccc2sccc2c1OCc1ccc(C(F)(F)F)cc1)C(=O)O,,ClCCl,,,,val
US20160185727A1,COC[C@@H]1CC[C@@H](Oc2cccc([N+](=O)[O-])c2C#N)CC1>>COC[C@@H]1CC[C@@H](Oc2cccc(N)c2C#N)CC1,[Pd],CCO,,,,val
US20050267105A1,Cn1nnc(-c2cc(F)ccc2Br)n1.N#C[Cu]>>Cn1nnc(-c2cc(F)ccc2C#N)n1,,CN(C)C=O,,,,val
US20090270467A1,CC(C)(C)OC(=O)N1C[C@@H](N=[N+]=[N-])[C@H](O)C1>>CC(C)(C)OC(=O)N1C[C@@H](N)[C@H](O)C1,[Pd],CCO,,,,val
US05569654,CC1=NC(NC(=O)OCc2ccccc2)C(=O)Nc2ccccc21.CN(C(=O)CBr)c1ccccc1>>CC1=NC(NC(=O)OCc2ccccc2)C(=O)N(CC(=O)N(C)c2ccccc2)c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20140228386A1,Brc1cnccc1C1CCCC1.O=C1NCCN1c1ccnc(Cl)c1>>O=C1N(c2ccnc(Cl)c2)CCN1c1cnccc1C1CCCC1,I[Cu]I,C1COCCO1,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US05294734,C=C(COCC)C(O)C(NC=O)C(=O)OCC.O=S(Br)Br>>CCOCC(=CC(NC=O)C(=O)OCC)CBr,,ClCCCl,,O,,val
US20100158818A1,CC(C)(CC(=O)Cl)N=[N+]=[N-].CNCCCN(C)C>>CN(C)CCCN(C)C(=O)CC(C)(C)N=[N+]=[N-],,ClCCCl,,CCN(C(C)C)C(C)C,[Na+].[OH-],val
US20060194797A1,BrCc1ccccc1.O=C(O)c1cccc([N+](=O)[O-])c1O>>O=C(O)c1cccc([N+](=O)[O-])c1OCc1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06641990B1,CCCCCCCCCCCCBr.COC(=O)c1cc(Cl)c(O)c(Cl)c1>>CCCCCCCCCCCCOc1c(Cl)cc(C(=O)OC)cc1Cl,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20080318929A1,NCc1cccc(Br)c1.O=[N+]([O-])c1cnc(Cl)nc1NC[C@@H]1CC[C@@H](CO)CC1>>O=[N+]([O-])c1cnc(NCc2cccc(Br)c2)nc1NC[C@@H]1CC[C@@H](CO)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160031871A1,Br.CCOC(=O)c1cnc(N)s1>>CCOC(=O)c1cnc(Br)s1,[Cu]Br,ClCCl,O,O=N[O-].[Na+],,val
US20090324581A1,CC(C)(C)OC(=O)CCN(CC(=O)N1CCc2cc(O)ccc21)C(=O)OC(C)(C)C.Fc1cc(C2CCCCC2)ccc1CCl>>CC(C)(C)OC(=O)CCN(CC(=O)N1CCc2cc(OCc3ccc(C4CCCCC4)cc3F)ccc21)C(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030013751A1,CNC.C[C@@H](CS(=O)(=O)Cl)C(=O)OCc1ccccc1>>C[C@@H](CS(=O)(=O)N(C)C)C(=O)OCc1ccccc1,,ClCCl,,,,val
US20130188270A1,CC(=O)Cl.CCCCC(CC)Cn1c2ccccc2c2ccc3ccccc3c21.Cc1cc(C)c(C(=O)Cl)c(C)c1>>CCCCC(CC)Cn1c2ccc(C(C)=O)cc2c2cc(C(=O)c3c(C)cc(C)cc3C)c3ccccc3c21,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20150045348A1,NC(=O)c1cncn1NC(=O)COCc1ccccc1>>O=c1[nH]c(COCc2ccccc2)nn2cncc12,,CCO,O,[K+].[OH-],,val
US20090030058A1,Cc1ccc(S(=O)(=O)O)cc1.Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(C(=O)NOCCO)cc21>>Cc1ccc(S(=O)(=O)O)cc1.Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(C(=O)NOCCO)cc21,,CO,,O,,val
US04675324,CCC(=O)Cl.CCC(=O)N1CCC(=O)c2cc(O)ccc21>>CCC(=O)Oc1ccc2c(c1)C(=O)CCN2C(=O)CC,CN(C)c1ccncc1,ClC(Cl)Cl,,CN(C)c1ccccc1,,val
US20030050330A1,CCOC(C)n1cnc(-c2ccc(SC)cc2)c1-c1ccc(F)cc1.CN(C)C=O>>CSc1ccc(-c2nc(C=O)[nH]c2-c2ccc(F)cc2)cc1,,C1CCOC1,,CN(C)CCN(C)C,[Li]CCCC,val
US05912377,C=CCc1ccc(O)cc1.N#CBr>>C=CCc1ccc(OC#N)cc1,,ClCCl,,CCN(CC)CC,,val
US20040259912A1,COC(=O)c1cc(N)ccc1OC(c1ccccc1)c1cccc(Cl)c1.COc1ccc(N=C=O)cc1OC>>COC(=O)c1cc(NC(=O)Nc2ccc(OC)c(OC)c2)ccc1OC(c1ccccc1)c1cccc(Cl)c1,,C1CCOC1,,,,val
US20090264650A1,CC1(O)CCC(N2CCC(Cc3ccc(O)cc3Cl)C2=O)CC1.O=S(=O)(O)C(F)(F)F>>CC1(O)CCC(N2CCC(Cc3ccc(OS(=O)(=O)C(F)(F)F)cc3Cl)C2=O)CC1,,c1ccncc1,,,,val
US20120028961A1,COc1ccc(F)c(C=O)c1.C[N+](=O)[O-]>>COc1ccc(F)c(C=C[N+](=O)[O-])c1,,CC(=O)O,,C,O=C[O-].[NH4+],val
US20150166483A1,COc1cc(OCCOCCOCCN(C)C)cc([N+](=O)[O-])c1>>COc1cc(N)cc(OCCOCCOCCN(C)C)c1,[Pd],CCO,,,,val
US20130158009A1,CC(C)(C)OC(=O)N1CCC(NC(=O)C(Br)CCCBr)CC1>>CC(C)(C)OC(=O)N1CCC(N2CCCC(Br)C2=O)CC1,,CN(C)C=O,,[H-].[Na+],,val
US04237323,CC(=O)O.CC(=O)OC(C)=O.O=S(=O)(O)O.c1ccc2ccccc2c1>>CC(=O)OC(C)=O.O=S(=O)(O)c1cccc2ccccc12,,CC(=O)O,,,,val
US20150329542A1,CNS(=O)(=O)c1ccccc1.N#Cc1nccnc1Cl>>CN(c1nccnc1C#N)S(=O)(=O)c1ccccc1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120225867A1,C[C@@H](CO)NC(=O)OC(C)(C)C.N#Cc1ccc(-c2[nH]ncc2C#N)cc1Cl>>C[C@H](N)Cn1cc(C#N)c(-c2ccc(C#N)c(Cl)c2)n1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100016314A1,CC(C)(C)OC(=O)N1CC2CC(=O)CC2C1>>O=C1CC2CNCC2C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06069156,CCCC#C[Sn](CCCC)(CCCC)CCCC.COC(=O)c1ccc(OS(=O)(=O)C(F)(F)F)c(NC(=O)OCc2ccccc2)c1>>CCCC#Cc1ccc(C(=O)OC)cc1NC(=O)OCc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,[Cl-].[Li+],,val
US20140315886A1,COc1cc(Br)cc(C(N)=O)c1N.O=C(Cl)c1cccnc1>>COc1cc(Br)cc(C(N)=O)c1NC(=O)c1cccnc1,,ClCCl,,CCN(CC)CC,,val
US20020147286A1,CC(C)(C)N[Si](C)(C)Cl.Cc1ccc2c(c1)c1c(n2C)Cc2ccccc2-1>>Cc1ccc2c(c1)c1c(n2C)C(N([SiH](C)C)C(C)(C)C)c2ccccc2-1,,CCOCC,,CCCCCC,[Li]CCCC,val
US20150018335A1,CC(C)(C)OC(=O)N1CCNCC1.O=Cc1c(Cl)cccc1N1CCCC1>>CC(C)(C)OC(=O)N1CCN(Cc2c(Cl)cccc2N2CCCC2)CC1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080207665A1,CCOC(=O)N1C2CCC1CC(=O)C2.OCc1ccc(F)cc1Br>>CCOC(=O)N1C2CCC1CC(O)(c1cc(F)ccc1CO)C2,,C1CCOC1,Cc1ccccc1,CCCCCC,[Li]CCCC,val
US04851418,CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)NC1CCN(Cc2ccccc2)C1>>CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)NC1CCNC1,[Pd],CO,,[H][H],,val
US20160002169A1,CCOc1ccc2c(c1)CCN(C(=O)OC(C)(C)C)C2C(=O)O.COCC(C)(C)c1c(F)cc(N)cc1F>>CCOc1ccc2c(c1)CCN(C(=O)OC(C)(C)C)C2C(=O)Nc1cc(F)c(C(C)(C)COC)c(F)c1,CN(C)c1ccncc1,CCOC(C)=O,O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20030186901A1,Nc1ccccc1.O=C(O)c1ccc2c(c1)C(=O)OC2=O>>O=C(O)c1ccc2c(c1)C(=O)N(c1ccccc1)C2=O,,CC(=O)O,,,,val
US20100240658A1,CC(C)CO.COC(=O)c1ccc(-c2noc(-c3ccc(-c4ccccc4C)c(COS(C)(=O)=O)c3)n2)cc1F>>Cc1ccccc1-c1ccc(-c2nc(-c3ccc(C(=O)O)c(F)c3)no2)cc1COCC(C)C,,CC(C)CO,,Cl,[Na+].[OH-],val
US04788206,CCCCC/C(=C\C=C\C(=O)OC)c1ccc(OC)cc1>>CCCCC/C(=C\C=C\C(=O)O)c1ccc(OC)cc1,,CO,,[Na+].[OH-],,val
US20080076771A1,CN(C)C(=O)CCl.NC(N)=S>>CN(C)C(=O)CSC(=N)N,,CC(C)=O,,,,val
US03957851,CCOC(=O)C1(c2ccccc2)CCC=CC1O.O=S(Cl)Cl>>CCOC(=O)C1(c2ccccc2)CCC=CC1Cl,,CN(C)C=O,,,,val
US20110053904A1,BrCCOCCBr.CSc1cc(C(F)(F)F)ccc1C(=O)N[C@@H]1CCCC[C@@H]1N>>CSc1cc(C(F)(F)F)ccc1C(=O)N[C@@H]1CCCC[C@@H]1N1CCOCC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20030105139A1,Nc1cc(-c2ccccc2)cc(-c2cccnc2)c1.O=C(Cl)Oc1ccccc1>>O=C(Nc1cc(-c2ccccc2)cc(-c2cccnc2)c1)Oc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US05824682,N#CCCN(Cc1ccccc1)CC1CCc2ccccc2O1>>NCCCN(Cc1ccccc1)CC1CCc2ccccc2O1,[Ni],CO,,[H][H],,val
US20120157487A1,Nc1cc(Cl)ccc1SCc1ccc([N+](=O)[O-])cc1.O=S(=O)(Cl)c1cc2ccccc2o1>>O=[N+]([O-])c1ccc(CSc2ccc(Cl)cc2NS(=O)(=O)c2cc3ccccc3o2)cc1,,c1ccncc1,,,,val
US06043254,CC(=O)OC(C)=O.O=C1Nc2ccc([N+](=O)[O-])cc2/C1=C(/Nc1ccc2c(c1)CCNC2)c1ccccc1>>CC(=O)N1CCc2cc(N/C(=C3\C(=O)Nc4ccc([N+](=O)[O-])cc43)c3ccccc3)ccc2C1,,CC(=O)O,O,CCN(C(C)C)C(C)C,Cl,val
US04519937,CCN(CC)CC.Cc1cccc(O)c1>>c1ccc2ncccc2c1,[Pt],,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20030097010A1,Cc1ccc(C(=O)c2cc(C(=O)O)c(C(=O)c3ccc(C)cc3)cc2C(=O)O)cc1>>Cc1ccc(Cc2cc(C(=O)O)c(Cc3ccc(C)cc3)cc2C(=O)O)cc1,[Pd],CC(=O)O,,[H][H],,val
US20140303186A1,CCOC(=O)Cc1nn(Cc2ccc(N)cc2)c2ccccc12.O=C(Cl)c1ccc(Cl)cc1>>CCOC(=O)Cc1nn(Cc2ccc(NC(=O)c3ccc(Cl)cc3)cc2)c2ccccc12,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20120122842A1,CC(C)C(=O)NC1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1>>CC(C)C(=O)N[C@@H]1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1,,CO,,,,val
US05569664,C=O.CCOC(=O)C1CCNCC1.Fc1cccc2[nH]ccc12>>CCOC(=O)C1CCN(Cc2c[nH]c3cccc(F)c23)CC1,,C1COCCO1,CC(=O)O,O=C([O-])O.[Na+],,val
US20020188000A1,COC(=O)c1cc(OC)ccn1.NN>>COc1ccnc(C(=O)NN)c1,,CO,,O,,val
US04515788,CCC(=O)OC(C)Cl.O=C(CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CCS[C@H]12)c1cscn1)OC(c1ccccc1)c1ccccc1>>CCC(=O)OC(C)OC(=O)C1=CCS[C@@H]2C(NC(=O)C(=NOCC(=O)OC(c3ccccc3)c3ccccc3)c3cscn3)C(=O)N12,,CS(C)=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20050176754A1,CC(C)(C)OC(=O)c1n[nH]c2cc(C3(O)CCOCC3)ccc12>>O=C(O)c1n[nH]c2cc(C3=CCOCC3)ccc12,,O=C(O)C(F)(F)F,,,,val
US03980788,CC(=O)OC(C)=O.CNC1CCCN(C2c3ccccc3Oc3ccccc32)C1>>CC(=O)N(C)C1CCCN(C2c3ccccc3Oc3ccccc32)C1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20070197478A1,Cc1c(O)cc(O)nc1Cl.O=[N+]([O-])O>>Cc1c(Cl)nc(O)c([N+](=O)[O-])c1O,,CC(=O)O,,,,val
US06602889B1,C#Cc1ccc2c(ccn2-c2ccc(F)cc2)c1.C[Si](C)(C)N=[N+]=[N-]>>Fc1ccc(-n2ccc3cc(-c4c[nH]nn4)ccc32)cc1,,ClCCl,,Cl,[Na+].[OH-],val
US06166006,CI.CN(Cc1ccc(NC(=O)C2=Cc3cc(-c4ccc(N5CCCCC5)cc4)ccc3CCC2)cc1)C1CCOCC1>>C[N+](C)(Cc1ccc(NC(=O)C2=Cc3cc(-c4ccc(N5CCCCC5)cc4)ccc3CCC2)cc1)C1CCOCC1.[I-],,CN(C)C=O,,,,val
US20110301143A1,CCOC(=O)Cn1nnc(-c2nc(N3CCN(c4cccc(C(F)(F)F)c4)CC3)no2)n1>>O=C(O)Cn1nnc(-c2nc(N3CCN(c4cccc(C(F)(F)F)c4)CC3)no2)n1,,C1CCOC1,,[Na+].[OH-],,val
US20160031829A1,CCSc1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C(=O)NC.O=C(OO)c1cccc(Cl)c1>>CCS(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C(=O)NC,,ClCCl,,,,val
US20150018547A1,CCOC(=O)CBr.SCC[C@@H]1COc2cc(OCc3ccc(Cl)cc3Cl)ccc21>>CCOC(=O)CSCC[C@@H]1COc2cc(OCc3ccc(Cl)cc3Cl)ccc21,,O,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20120108574A1,Brc1ccc(Br)cc1.CC(C)(C)S(=O)N=C1COC1>>CC(C)(C)S(=O)NC1(c2ccc(Br)cc2)COC1,,C1CCOC1,,[Li]CCCC,,val
US20100048570A1,COC(=O)C1SCCN1C(=O)C[C@@H](Cc1cc(F)c(F)cc1F)NC(=O)OC(C)(C)C.Cl>>COC(=O)C1SCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F.Cl,,CCOC(C)=O,,C1COCCO1,,val
US20040122244A1,COc1c(C)c(Cc2ccc(OCc3ccccc3)c(C(=O)O)c2)c(OC)c(OC)c1OC.COc1ccc(N)cc1>>COc1ccc(NC(=O)c2cc(Cc3c(C)c(OC)c(OC)c(OC)c3OC)ccc2OCc2ccccc2)cc1,,ClCCl,,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US20040002492A1,COc1ccccc1S.O=C(O)c1cc([N+](=O)[O-])ccc1Br>>COc1ccccc1Sc1ccc([N+](=O)[O-])cc1C(=O)O,[Cu],O,,[K+].[OH-],,val
US20080004265A1,ClCCCI.N#CC1CCCC1>>N#CC1(CCCCl)CCCC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05449676,CCOc1cc(-c2ccc(N)nn2)ccc1OC(F)F.O=C(OO)c1cccc(Cl)c1>>CCOc1cc(-c2ccc(N)[n+]([O-])n2)ccc1OC(F)F,,CC(=O)O,,O,,val
US20060263793A1,C=CCOCCOCCOCCOCCOC(=O)CCC(=O)O.O=C1CCC(=O)N1O>>C=CCOCCOCCOCCOCCOC(=O)CCC(=O)ON1C(=O)CCC1=O,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05521192,CCCCCCCCCCC(=O)O.O=C(Cl)C(=O)Cl>>CCCCCCCCCCC(=O)Cl,CN(C)C=O,ClCCl,,,,val
US07265140B2,CCC(=O)OCOC(=O)N(C[C@H]1CN(c2ccc(C3CCS(=O)(=O)CC3)c(F)c2)C(=O)O1)C(C)=O.ClCCl>>O=C(NC[C@H]1CN(c2ccc(C3CCS(=O)(=O)CC3)c(F)c2)C(=O)O1)OCOC(=O)C1CCOCC1,,ClCCl,,,,val
US04362712,C=O.O=C(O)Cc1cccc2ccccc12>>C=O.O=C(O)Cc1cccc2ccccc12,,O,,CC(=O)O,O=S(=O)(O)O,val
US20160243100A1,O=S(=O)(c1ccc(C(F)(F)F)cc1Br)C(F)(F)c1ccncc1>>O=S(=O)(c1ccc(C(F)(F)F)cc1Br)C(F)(F)C1CCNCC1,O=[Pt]=O,CC(=O)O,,O=C(O)C(F)(F)F,,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccccn2)c1C#N.OCCc1ccccn1>>N#Cc1c(OCCc2ccccn2)nc(N)nc1-c1ccccn1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US06350907B1,Cc1cc(CCC[C@H](CC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)N[C@H](C)c2ccccc2)C(C)(C)C)ccc1Oc1ccccc1>>Cc1cc(CCC[C@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C)c2ccccc2)C(C)(C)C)ccc1Oc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100256156A1,COc1ccc(-c2cc(C3OCCO3)c(C)s2)cn1>>COc1ccc(-c2cc(C=O)c(C)s2)cn1,,C1CCOC1,,Cl,O,val
US04788199,BrCc1cc2ccccc2c(-c2ccccc2)n1.CCOC(=O)CC(=O)OCC>>O=C(O)CCc1cc2ccccc2c(-c2ccccc2)n1,,C1CCOC1,,O,[H-].[Na+],val
US20040006245A1,C#CC(C)(O)CC.O=C(NOCCO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F>>CCC(C)(O)C#Cc1ccc(Nc2c(C(=O)NOCCO)ccc(F)c2F)c(F)c1,[Cu]I,CCOCC,CO,,,val
US20150119362A1,CCOC(=O)Cc1ccc(Nc2cc(-c3ccsc3)nc3c2CCC3)cc1.N>>NC(=O)Cc1ccc(Nc2cc(-c3ccsc3)nc3c2CCC3)cc1,,CO,,,,val
US20020013476A1,CCC=CC(C=O)(CC)CSc1ccccc1C=O>>CCCCC1(CC)C=Cc2ccccc2SC1,[Zn],COCCOC,,Cl,ClCCl,val
US20110130398A1,CC(C)(C)CC1NC(C(=O)OC(C)(C)C)C(c2cc(F)cc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12.O=C(O)C(F)(F)F>>CC(C)(C)CC1NC(C(=O)O)C(c2cc(F)cc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04208205,CNOC.O=C(Cl)c1ccccc1Sc1ccccc1>>CON(C)C(=O)c1ccccc1Sc1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US05693651,CCO.N=C1NC(=O)C(Cc2cnc3cc(OCc4ccccc4C(F)(F)F)ccc3c2)S1>>O=C1NC(=O)C(Cc2cnc3cc(OCc4ccccc4C(F)(F)F)ccc3c2)S1,,Cl,,,,val
US05344843,COc1cccs1.OCCOC1CCCCCCC1>>c1csc(OCCOC2CCCCCCC2)c1,Cc1ccc(S(=O)(=O)O)cc1,c1ccccc1,,,,val
US20050203078A1,COC(=O)c1ccc(Br)c([N+](=O)[O-])c1.O=C1COCCN1>>COC(=O)c1ccc(N2CCOCC2=O)c([N+](=O)[O-])c1,,C1COCCO1,,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20140018345A1,CC(=O)Nc1nc2c(-c3cccc(C(F)(F)F)c3)c(C)c(C(=O)C=CN(C)C)cn2n1.CS(=O)(=O)c1cc(C#N)ccc1NN>>Cc1c(-c2ccnn2-c2ccc(C#N)cc2S(C)(=O)=O)cn2nc(N)nc2c1-c1cccc(C(F)(F)F)c1,,CCCCO,,CCOC(C)=O,Cl,val
US20090062366A1,CC(C)(C)[Si](C)(C)OC[C@@H]1CN(C(=O)C(F)(F)F)C[C@H]1c1ccccc1>>O=C(N1C[C@@H](c2ccccc2)[C@H](CO)C1)C(F)(F)F,,ClCCl,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US04556677,C=CCBr.CCC(=C(c1ccccc1)c1ccc(O)cc1)C1CCCC1>>C=CCOc1ccc(C(=C(CC)C2CCCC2)c2ccccc2)cc1,,COCCOC,,[H-].[Na+],,val
US20100056516A1,CC(C)(C)OC(=O)n1cc(B2OC(C)(C)C(C)(C)O2)cn1.O=c1cc(OS(=O)(=O)C(F)(F)F)c2cccnc2n1OCc1ccccc1>>O=c1cc(-c2cn[nH]c2)c2cccnc2n1OCc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US04870074,CCOC(=O)Cl.O=C1c2ccccc2C(=O)N1CC1CN(Cc2ccccc2)CCO1>>CCOC(=O)N1CCOC(CN2C(=O)c3ccccc3C2=O)C1,,Cc1ccccc1,,,,val
US06492416B1,BrBr.CCC1(C)OC(c2ccc(S(C)(=O)=O)cc2)=CC1=O>>CCC1(C)OC(c2ccc(S(C)(=O)=O)cc2)=C(Br)C1=O,,ClC(Cl)(Cl)Cl,,CC(=O)O,,val
US20140005213A1,C/C=C/C=O.COc1cc(N)ccc1C>>COc1cc2nc(C)ccc2cc1C,,Cl,,[NH4+].[OH-],,val
US20160137648A1,Cc1ccc(CC(=O)O)cn1>>Cc1ccc(CCO)cn1,,C1CCOC1,,B,CSC,val
US20020147286A1,CC(C)(C)N[Si](C)(C)Cl.CCn1c2c(c3ccccc31)-c1ccccc1C2>>C[SiH](C)N(CCC1c2ccccc2-c2c1[nH]c1ccccc21)C(C)(C)C,,CCOCC,,CCCCCC,[Li]CCCC,val
US20090099177A1,CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1.N>>CC(C)COc1ccc(Cl)cc1Cc1cccc(C(N)=O)n1,CN(C)C=O,CCOCC,ClCCl,O=C(Cl)C(=O)Cl,,val
US03966746,CCOC(=O)C(=CNc1ccnn1Cc1ccco1)C(=O)OCC>>CCOC(=O)c1cnc2c(cnn2Cc2ccco2)c1O,,c1ccc(Oc2ccccc2)cc1,,CCO,,val
US20050038072A1,COC(=O)c1ccc(CN2CCC(=O)C(C(c3ccccc3)c3ccccc3)C2)cc1>>O=C(O)c1ccc(CN2CCC(=O)C(C(c3ccccc3)c3ccccc3)C2)cc1,,CO,,Cl,[Na+].[OH-],val
US20050096359A1,CCOC(C)=O.NCc1ccccc1Br.O=C([O-])O>>CC(C)(C)OC(=O)NCc1ccccc1Br,,CCOC(C)=O,O,Cl,,val
US05831115,C1CCOC1.CCN(CC)CC.CS(C)=O.ClCCl.O=C(O)CC(O)(CC(=O)O)C(=O)O>>O=CC/C=C\COCc1ccccc1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20110039889A1,CC(C)Oc1ccc(-c2nc(-c3cccc4c(N5CCN(C(=O)OC(C)(C)C)CC5)nccc34)no2)cc1Cl.O=C(O)C(F)(F)F>>CC(C)Oc1ccc(-c2nc(-c3cccc4c(N5CCNCC5)nccc34)no2)cc1Cl.O=C(O)C(F)(F)F,,CS(C)=O,,ClCCl,,val
US07163921B1,CSC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C.NCCCC(=O)O>>CC(C)(C)OC(=O)N=C(NCCCC(=O)O)NC(=O)OC(C)(C)C,,C1CCOC1,O,,,val
US20130203755A1,CN1CCN(Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1[nH]c2ncc(Br)cc2c1-c1csc(N)n1>>Cc1[nH]c2ncc(-c3ccc(CN4CCN(C)CC4)cc3)cc2c1-c1csc(N)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20080255167A1,COC(OC)N(C)C.Nc1nc(CCc2cccc(-c3ccco3)c2)cc(=O)[nH]1>>CN(C)C=Nc1nc(CCc2cccc(-c3ccco3)c2)cc(=O)[nH]1,,CN(C)C=O,,O,,val
US04851419,CN(C)c1ccc(N(C)C)c(Sc2nc3cc(Cl)ccc3[nH]2)c1.O=C(OO)c1cccc(Cl)c1>>CN(C)c1ccc(N(C)C)c(S(=O)c2nc3cc(Cl)ccc3[nH]2)c1,,CCOC(C)=O,,CCOCC,,val
US20080045511A1,N#Cc1cc(Cl)cc(Oc2c(Br)ccc(C=O)c2F)c1>>N#Cc1cc(Cl)cc(Oc2c(Br)ccc(CO)c2F)c1,,C1CCOC1,CO,[BH4-].[Na+],,val
US20130131039A1,CCOP(=O)(CC#N)OCC.O=C1CC2(CCC2)C1>>N#CC=C1CC2(CCC2)C1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US05525617,CC(C)(C)OC(=O)N1CCC(CC=C2Cc3ccc(C(=O)O)cc3C2=O)CC1.CI>>COC(=O)c1ccc2c(c1)C(=O)C(=CCC1CCN(C(=O)OC(C)(C)C)CC1)C2,,CCOC(C)=O,CO,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130331419A1,CCC(/C=C/C#N)(c1ccc(Cl)cc1)n1ncc2c(N(COCC[Si](C)(C)C)S(C)(=O)=O)cccc21.C[S+](C)(C)=O>>CCC(c1ccc(Cl)cc1)(C1CC1C#N)n1ncc2c(N(COCC[Si](C)(C)C)S(C)(=O)=O)cccc21,,CS(C)=O,,[H-].[Na+],,val
US20100160324A1,O=C1c2ccccc2C(=O)N1c1n[nH]cc1[N+](=O)[O-]>>Nc1c[nH]nc1N1C(=O)c2ccccc2C1=O,[Pd],CN(C)C=O,,,,val
US20150336935A1,COc1cc(OC)cc(C(=O)[C@H]2[C@H](C)[C@@H](COS(C)(=O)=O)C[C@H]3C(C)(C)CCC[C@]23C)c1.[N-]=[N+]=[N-]>>COc1cc(OC)cc(C(=O)[C@H]2[C@H](C)[C@@H](CN=[N+]=[N-])C[C@H]3C(C)(C)CCC[C@]23C)c1,,CCOCC,,CN(C)C=O,,val
US20120232068A1,CC(=O)CCl.CC(C)(C)NS(=O)(=O)c1cc(Br)cnc1N>>Cc1cn2cc(Br)cc(S(=O)(=O)NC(C)(C)C)c2n1,,CCO,,,,val
US20140349990A1,CCOC(=O)c1nn(C)c(C)c1C(O)c1ccc(Cl)cc1.Cn1cc(N)cc(F)c1=O>>CCOC(=O)c1nn(C)c(C)c1C(Nc1cc(F)c(=O)n(C)c1)c1ccc(Cl)cc1,,CO,ClCCl,,,val
US20060046985A1,COC(=O)c1nc2n(c(=O)c1O)CCCCC2.O=C(OC(=O)c1ccccc1)c1ccccc1>>COC(=O)c1nc2n(c(=O)c1OC(=O)c1ccccc1)CCCCC2,,c1ccncc1,,CN(C)c1ccccn1,,val
US20130131039A1,CC(C)(C)OC(=O)N1CCC(c2ccc(-c3cc4nccn4c(O)n3)cc2)CC1>>Oc1nc(-c2ccc(C3CCNCC3)cc2)cc2nccn12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100056516A1,CCOC(=O)c1ccccc1Br.OB(O)c1cccnc1>>CCOC(=O)c1ccccc1-c1cccnc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20140057902A1,CC(=O)c1cccc2c1CCN1C(=O)CNC(=O)C=C21.CCc1c[nH]cn1>>CCc1cn(C2=NCC(=O)N3CCc4c(C(C)=O)cccc4C3=C2)cn1,,ClCCCl,O,O=P(Cl)(Cl)Cl,O=C([O-])O.[Na+],val
US04925658,COc1ccc(C(=O)O)cc1C(C)(C)C.O=C(O)c1ccc(S)cc1>>COc1ccc(C(=O)Sc2ccc(C(=O)O)cc2)cc1C(C)(C)C,,ClCCl,,c1ccncc1,,val
US20130345247A1,COC1CCC2(CC1)Cc1cc(F)c(OCCCF)cc1C21N=C(C)C(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)=N1>>COC1CCC2(CC1)Cc1cc(F)c(OCCCF)cc1C21N=C(C)C(N)=N1,,Cc1ccccc1,,N,,val
US20120309754A1,Cc1nc2ccccc2nc1-c1cc2nc(N3CC[C@H](OS(C)(=O)=O)C3)cc(NC3CCOCC3)n2n1>>Cc1nc2ccccc2nc1-c1cc2nc(N3CC=CC3)cc(NC3CCOCC3)n2n1,,CC#N,,[F-].[K+],,val
US04205074,CI.c1csc(C(=C2CCCN3CCCCC23)c2cccs2)c1>>CI.c1csc(C(=C2CCCN3CCCCC23)c2cccs2)c1,,CC(C)=O,,,,val
US20090269301A1,CCOC(=O)C(=O)CC(=O)C1CC1.Nc1ccc2[nH]cnc2c1.O=Cc1ccc2nsnc2c1>>O=C(C1=C(O)C(=O)N(c2ccc3[nH]cnc3c2)C1c1ccc2nsnc2c1)C1CC1,,CCO,,,,val
US20120258968A1,CS(=O)(=O)NCc1ccc(N)cc1.Clc1cc(Cl)ncn1>>CS(=O)(=O)NCc1ccc(Nc2cc(Cl)ncn2)cc1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20100305131A1,CCOC(=O)c1cnc(CC)s1>>CCc1ncc(C(=O)O)s1,,CO,,[Na+].[OH-],,val
US06143764,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.O=C=Nc1ccccc1>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC,,Cc1ccccc1,,,,val
US20070078121A1,COC(=O)C1Cc2cc(-n3nc(C(C)(C)C)cc3NC(=O)Nc3cccc(Oc4cccnc4)c3)ccc2CN1.NCC(O)CO>>CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cccnc3)c2)n(-c2ccc3c(c2)CC(C(=O)NCC(O)CO)NC3)n1,,CO,Cl,,,val
US06936602B1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3C(C)C)cc1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCN3C(C)C)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20150329535A1,CCOC(=O)c1cc(Cl)c(NC(=O)CCCc2ccc(-c3ccccc3)c(NC(=O)OC34CCN(CC3)CC4)c2)cc1OC>>COc1cc(NC(=O)CCCc2ccc(-c3ccccc3)c(NC(=O)OC34CCN(CC3)CC4)c2)c(Cl)cc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06335324B1,N[C@@H]1CC[C@@H](c2ccccc2)CC1.O=C(Cl)Cl>>O=C=N[C@@H]1CC[C@@H](c2ccccc2)CC1,,CCOCC,Cc1ccccc1,,,val
US20090054399A1,COc1c2c(c(C(=O)N(CCCCOS(C)(=O)=O)CCOCc3ccccc3)[nH]c1=O)CCN(Cc1ccc(F)c(Cl)c1)C2=O>>COc1c2c(c3n(c1=O)CCCCN(CCOCc1ccccc1)C3=O)CCN(Cc1ccc(F)c(Cl)c1)C2=O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030018067A1,CCCCC(=O)c1c(-c2ccc3c(C)c(OC(Cc4ccccc4)C(=O)OCC)ccc3c2)oc2ccccc12>>CCCCC(=O)c1c(-c2ccc3c(C)c(OC(Cc4ccccc4)C(=O)O)ccc3c2)oc2ccccc12,,C1CCOC1,O,[K+].[OH-],,val
US20140249104A1,CC[Si](C#Cc1ccc(F)c([C@]2(CF)C[C@@H](C(F)(F)F)OC(N)=N2)c1)(CC)CC>>C#Cc1ccc(F)c([C@]2(CF)C[C@@H](C(F)(F)F)OC(N)=N2)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090137557A1,Cc1nc(-c2ccccc2OCc2ccccc2)n(CCc2ccccc2)c(=O)c1Br.N#Cc1ccc(B(O)O)s1>>Cc1nc(-c2ccccc2OCc2ccccc2)n(CCc2ccccc2)c(=O)c1-c1ccc(C#N)s1,,Cc1ccccc1,,COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20060166933A1,C[Si](C)(C)CCOCCl.Cc1cc(=O)oc2cc(OCOCC[Si](C)(C)C)ccc12>>Cc1c(COCC[Si](C)(C)C)c(=O)oc2cc(OCOCC[Si](C)(C)C)ccc12,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100324088A1,CCOC(=O)c1cn(Cc2ccc(-c3ccccc3)cc2)c2c(c1=O)C(O)CCC2.CI>>CCOC(=O)c1cn(Cc2ccc(-c3ccccc3)cc2)c2c(c1=O)C(OC)CCC2,,CN(C)C=O,,O,[H-].[Na+],val
US20160002248A1,Cc1ccc(CN)cn1.O=C(O)c1cn(CC(F)CCc2cc3cc(-c4ccccc4F)[nH]c3nn2)nn1>>Cc1ccc(CNC(=O)c2cn(CC(F)CCc3cc4cc(-c5ccccc5F)[nH]c4nn3)nn2)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100240658A1,CC(C)(C)OC(=O)CNCc1cccc(C#N)c1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)CN(Cc1cccc(C#N)c1)C(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20060025467A1,CCN(CC)CC.COc1cccc2ccn(C(CCO)c3cccnc3)c12>>CNCCC(c1cccnc1)n1ccc2cccc(OC)c21,,ClCCl,,CS(=O)(=O)Cl,,val
US20090030082A1,COC(=O)Cc1cccc(OCCCNCC(c2ccccc2)c2ccccc2)c1.FC(F)(F)c1cccc(CBr)c1>>COC(=O)Cc1cccc(OCCCN(Cc2cccc(C(F)(F)F)c2)CC(c2ccccc2)c2ccccc2)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100305111A1,COC(=O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCSCC2)C1>>O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCSCC2)C1,,CO,,CC(C)(C)[O-].[K+],,val
US20100168063A1,O=C(NCc1ccc(Cl)c(Cl)c1)c1nc2c3c(N4CCOCC4)cccc3on2c(=O)c1OCc1ccccc1>>O=C(NCc1ccc(Cl)c(Cl)c1)c1nc2c3c(N4CCOCC4)cccc3on2c(=O)c1O,Cl[Fe](Cl)Cl,ClCCl,,Cl,,val
US20130053581A1,CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@H]2Cc3c(cccc3OC(=O)c3ccccc3)C[C@H]12>>CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@@H]2Cc3c(cccc3OC(=O)c3ccccc3)C[C@H]12,[Pd],CO,,,,val
US20110065706A1,CC(C)(C)OC(=O)N1CCN(c2ncc(O)cn2)CC1.CSc1ccc(CO)cc1>>CSc1ccc(COc2cnc(N3CCN(C(=O)OC(C)(C)C)CC3)nc2)cc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04661438,COS(=O)(=O)C(F)(F)F.COc1cc2nc(C)[te]c2cc1OC>>COc1cc2[te]c(C)[n+](C)c2cc1OC.O=S(=O)([O-])C(F)(F)F,,ClCCl,,,,val
US20040138286A1,CS(=O)(=O)Cl.c1cc2[nH]ncc2cc1NC1CCNCC1>>CS(=O)(=O)N1CCC(Nc2ccc3[nH]ncc3c2)CC1,,C1CCOC1,,CCN(CC)CC,[Na+].[OH-],val
US04558134,NO.O=Cc1cc(Cl)ncc1Cl>>ON=Cc1cc(Cl)ncc1Cl,Cl,CC(C)O,,,,val
US20160228450A1,CCCCCCCOc1ccc(C(=O)NNC(=O)OC(C)(C)C)cc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCCCCCCOc1ccc(C(=S)NNC(=O)OC(C)(C)C)cc1,,C1CCOC1,,,,val
US20130317031A1,Cc1[nH]ncc1C(=O)NN.O=C(O)/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1>>Cc1[nH]ncc1C(=O)NNC(=O)/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1,,CCO,CCOC(C)=O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20050085465A1,CC(=O)N1CCNCC1.COc1cc2c(Oc3ccc4[nH]ccc4c3)ncnc2cc1OCCCBr>>COc1cc2c(Oc3ccc4[nH]ccc4c3)ncnc2cc1OCCCN1CCN(C(C)=O)CC1,,CCOC(C)=O,CN(C)C=O,,,val
US20120283239A1,CC(=O)Cl.Cn1nnc2c(C#N)nc(-c3ccc(OCCCN)c(C(F)(F)F)c3)cc21>>CC(=O)NCCCOc1ccc(-c2cc3c(nnn3C)c(C#N)n2)cc1C(F)(F)F,,ClCCl,O,CCN(CC)CC,,val
US20060025474A1,CCC(CC)(c1ccc(O)c(C)c1)c1ccc(C#CC(O)C2(CC)CC2)c(C)c1>>CCC(CC)(c1ccc(O)c(C)c1)c1ccc(CCC(O)C2(CC)CC2)c(C)c1,[Pd],CCOC(C)=O,CO,,,val
US05135937,N#Cc1ccc(Cc2c[nH]nn2)cc1.O=C1CCCC1>>N#Cc1ccc(C(c2c[nH]nn2)C2(O)CCCC2)cc1,,C1CCOC1,,O,CC(C)[N-]C(C)C.[Li+],val
US20150329542A1,CNc1cc(OC)ccc1C#N.CS(=O)(=O)Cl>>COc1ccc(C#N)c(N(C)S(C)(=O)=O)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20150133428A1,CC(C)(C)C(O)COC(N)=O.CC(C)OC(=O)/N=N/C(=O)OC(C)C.CCOC(=O)c1[nH]nc(I)c1C(=O)OCC>>CCOC(=O)c1c(I)nn(CCNC(=O)OC(C)(C)C)c1C(=O)OCC,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160009744A1,CC(C)(C)OC(=O)N[C@H]1C[C@H](O)[C@@H](CO)C1.CC(C)(C)[Si](C)(C)Cl>>CC(C)(C)OC(=O)N[C@H]1C[C@H](O)[C@@H](CO[Si](C)(C)C(C)(C)C)C1,,CN(C)C=O,ClCCl,c1c[nH]cn1,,val
US20120190678A1,CC(C)(C)OC(=O)NCC=O.CSc1ncc2ccc3c(C(N)=O)nn(CC4CCNCC4)c3c2n1>>CSc1ncc2ccc3c(C(N)=O)nn(CC4CCN(CCNC(=O)OC(C)(C)C)CC4)c3c2n1,,CN(C)C=O,CO,CC(=O)O,[BH3-]C#N.[Na+],val
US20030187014A1,C=C1CC(=O)O1.Cc1cccc(N)c1C(=O)O>>CC(=O)Cc1nc2cccc(C)c2c(=O)o1,,CC(C)=O,,CC(=O)OC(C)=O,,val
US20150284370A1,CCN(c1cc(C#CC2CCNCC2)cc(C(=O)NCc2c(C(C)C)cc(C)[nH]c2=O)c1C)C1CCOCC1.C[C@@H]1CO1>>CCN(c1cc(C#CC2CCN(C[C@@H](C)O)CC2)cc(C(=O)NCc2c(C(C)C)cc(C)[nH]c2=O)c1C)C1CCOCC1,,CO,,,,val
US20110144085A1,CC(C)(C)OC(=O)N1CC[C@@H](F)[C@H](O)CC1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CC(C)(C)OC(=O)N1CC[C@@H](F)[C@H](OS(=O)(=O)c2ccc([N+](=O)[O-])cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20040198780A1,Cc1cccc(C(=O)Cl)c1.N[C@@H](CCCc1ccccc1)C(=O)O>>Cc1cccc(C(=O)N[C@@H](CCCc2ccccc2)C(=O)O)c1,,O,,[Na+].[OH-],,val
US20130029987A1,COC(=O)C12CCC(OC)(CC1)CC2>>COC12CCC(C(=O)O)(CC1)CC2,,[Na+],[OH-],Cl,,val
US04007217,CC(C)(C)c1ccc(C2(C(=O)[O-])CO2)cc1.CC(C)OC(C)C>>C=C(c1ccc(C(C)(C)C)cc1)C(O)C(=O)OCC,,O,,O=S(=O)(O)O,,val
US20120108574A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4cccc(NS(C)(=O)=O)c4)nc4n3-c3cccnc3Nc3ccccc3-4)cc2)CCC1.Cl.ClCCl>>CS(=O)(=O)Nc1cccc(-c2nc3n(c2-c2ccc(C4(N)CCC4)cc2)-c2cccnc2Nc2ccccc2-3)c1.Cl.Cl.Cl,,ClCCl,,C1COCCO1,,val
US20150232460A1,Cc1nc(C(F)(F)F)cnc1N[C@H]1CCC[C@@H]1NC(=O)OC(C)(C)C.Cl>>CN(c1cnc(C(F)(F)F)cn1)[C@H]1CCC[C@@H]1N.Cl,,CO,,C1COCCO1,,val
US20100266714A1,CNC(=O)c1cc(C(=O)OC)cc(-c2ccc(C)cn2)c1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CNC(=S)c1cc(C(=O)OC)cc(-c2ccc(C)cn2)c1,,CC(Cl)Cl,,ClCCl,,val
US20040038939A1,CI.CO.COC(=O)c1c(C(F)F)nc(C(F)(F)F)c(N=C=S)c1CC(C)C>>COC(=O)c1c(C(F)F)nc(C(F)(F)F)c(N=C(OC)SC)c1CC(C)C,,C1CCOC1,CO,C[O-].[Na+],,val
US20030125339A1,CC(O)C1CCCCN1.Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1>>Nc1ccc(C(OCCN2CCCCC2)(C(F)(F)F)C(F)(F)F)cc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150299188A1,CO.COCCOc1cccc([N+](=O)[O-])c1C(=O)Nc1cc(OCc2ncccc2F)ccc1C>>COCCOc1cccc2[nH]c(=O)n(-c3cc(OCc4ncccc4F)ccc3C)c(=O)c12,[Pd],C1CCOC1,,,,val
US05668098,BrCCBr.N[C@@H](CC(=O)O)C(=O)O.N[C@@H](CS(=O)(=O)O)C(=O)O>>N[C@@H](CS(=O)(=O)O)C(=O)O.N[C@H]1CC(=O)OCCOC1=O,,CCO,O,[Na+].[OH-],,val
US20070083053A1,CC(=O)Cc1ccc(Br)cc1[N+](=O)[O-]>>Cc1cc2ccc(Br)cc2[nH]1,[Pd],CCCCO,,[H][H],,val
US20060217372A1,CC(C)(C)CCCN.NC(=O)c1ccc(Oc2ccc(C=O)cc2F)cn1>>CC(C)(C)CCCNCc1ccc(Oc2ccc(C(N)=O)nc2)c(F)c1,,CO,,[BH4-].[Na+],,val
US20110105530A1,Nc1ccccc1NC(=O)c1ccnc(NC(=O)c2ccccc2)c1>>O=C(Nc1cc(-c2nc3ccccc3[nH]2)ccn1)c1ccccc1,,Cc1ccccc1,,O=P(Cl)(Cl)Cl,,val
US20080214520A1,BrBr.O=C(N1CCc2cccc(O)c2CC1)C(F)(F)F>>O=C(N1CCc2c(O)ccc(Br)c2CC1)C(F)(F)F,,CC#N,,,,val
US20110046157A1,COC(=O)CS.O=Cc1ccncc1F>>COC(=O)c1cc2ccncc2s1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150011621A1,CCCC[SnH](CCCC)CCCC.CCOc1ccc(C#CC(N)=O)cc1>>CCCC[Sn](CCCC)(CCCC)/C(=C/c1ccc(OCC)cc1)C(N)=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20110201604A1,COCCN.O=C(O)c1ccc2c(c1)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2CCF>>COCCNC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2CCF,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060257987A1,CCOC(=O)CCc1ccc(OCCC(C)OS(C)(=O)=O)cc1CC.CCc1ccc(O)c(-c2ccccn2)c1>>CCOC(=O)CCc1ccc(OCCC(C)Oc2ccc(CC)cc2-c2ccccn2)cc1CC,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150225397A1,C[C@@H]1C(=O)C(C#N)C[C@]2(c3ccccc3)c3nc(-c4ccc(O)cc4)ncc3CC[C@@H]12>>C[C@@H]1C(=O)C(C#N)=C[C@]2(c3ccccc3)c3nc(-c4ccc(O)cc4)ncc3CC[C@@H]12,,C1CCOC1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20140213571A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N)c(-c3ccc4c(n3)-c3cc5c(F)cccc5n3CO4)cc12.O=S(=O)(Cl)CCCCl>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(NS(=O)(=O)CCCCl)c(-c3ccc4c(n3)-c3cc5c(F)cccc5n3CO4)cc12,,ClCCl,,CCN(CC)CC,,val
US20010039286A1,Br[Mg]C1CCCCC1.CC(=O)N1CCC(=O)CC1>>CC(=O)N1CCC(O)(C2CCCCC2)CC1,,C1CCOC1,,[Cl-].[NH4+],,val
US20080318935A1,CCS(=O)(=O)Cl.CNC(=O)[C@@H](NC(=O)c1nc(-c2ccccc2)n2c1CNCCC2)C(C)(C)C>>CCS(=O)(=O)N1CCCn2c(-c3ccccc3)nc(C(=O)N[C@H](C(=O)NC)C(C)(C)C)c2C1,,ClCCl,,,,val
US20060211680A1,CN(C)CCCl.Cc1cc(O)c(C(=O)C=Cc2cccc(O)c2)c(=O)n1C>>Cc1cc(O)c(C(=O)C=Cc2cccc(OCCN(C)C)c2)c(=O)n1C,,CN(C)C=O,,Cl,[H-].[Na+],val
US04122260,CC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)Cn3cccc3C=O)C2SC1.CCOC(=O)N(C)CCl>>CCOC(=O)N(C)COC(=O)C1=C(COC(C)=O)CSC2C(NC(=O)Cn3cccc3C=O)C(=O)N12,,CN(C)C=O,,[Na],,val
US05373038,N=C(N)N.O=C1CC(=O)NC(=S)N1>>N=C(N)N.O=C1CC(=O)NC(=S)N1,,O,,O=C(O)O,,val
US20040157886A1,Fc1ccc(CC2CCNCC2)cc1.O=C(CCl)Nc1ccc2cn[nH]c2c1>>O=C(CN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc2cn[nH]c2c1,,CCOCC,,,,val
US05006563,CCN(CC)S(F)(F)F.CN(C)c1ccc(C(=O)C(O)c2cccc(Cl)c2)cc1>>CN(C)c1ccc(C(=O)C(F)c2cccc(Cl)c2)cc1,,ClCCl,,,,val
US20050124654A1,CN(C)CCOc1ccc2c(c1)CCCC2=O.NO>>CN(C)CCOc1ccc2c(c1)CCCC2=NO,,CCOC(C)=O,CO,CCN(CC)CC,Cl,val
US20140364412A1,CC(C)[Si](OCc1nn(CCOS(C)(=O)=O)cc1-n1nc(C(C)(C)C)cc1NC(=O)N[C@H]1CC[C@@H](Oc2ccc3nnc(N4CCCC[C@@H]4C)n3c2)c2ccccc21)(C(C)C)C(C)C.CNC>>CC(C)[Si](OCc1nn(CCN(C)C)cc1-n1nc(C(C)(C)C)cc1NC(=O)N[C@H]1CC[C@@H](Oc2ccc3nnc(N4CCCC[C@@H]4C)n3c2)c2ccccc21)(C(C)C)C(C)C,,C1CCOC1,,,,val
US20140243346A1,CCOC(=O)CCCCCC=O.O=C([O-])CC1CNc2nc(-c3ccccc3)c(-c3ccccc3)nc2C1CC(=O)[O-]>>CCOC(=O)CCCCCCN1CC(OC(C)=O)C(OC(C)=O)c2nc(-c3ccccc3)c(-c3ccccc3)nc21,,ClCCCl,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140045834A1,CC(C)(C)OC(=O)NCCN=C=S.COc1cc2c(NCC3CCOCC3)c(N)cnc2cc1-c1c(C)noc1C>>COc1cc2c(cc1-c1c(C)noc1C)ncc1nc(NCCN)n(CC3CCOCC3)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160194315A1,COC(=O)c1ccnc2cc(COc3cccc(C)c3)[nH]c12>>Cc1cccc(OCc2cc3nccc(C(=O)O)c3[nH]2)c1,,CC#N,O,,,val
US20100261719A1,C[C@H]1CNC[C@@H](C)O1.O=Cc1cc(Br)ccc1F>>C[C@H]1CN(c2ccc(Br)cc2C=O)C[C@@H](C)O1,,CC#N,,CCN(C(C)C)C(C)C,,val
US04208426,BrCc1ccccc1.CCCC1(C)CC(=O)c2ccc(O)c(C)c2O1>>CCCC1(C)CC(=O)c2ccc(OCc3ccccc3)c(C)c2O1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050203153A1,O=[N+]([O-])N1COc2ccc(-c3ccccc3)c(OCC3CCOC3)c21>>NN1COc2ccc(-c3ccccc3)c(OCC3CCOC3)c21,[Zn],,,,,val
US20130102621A1,CC(C)(C)OC(=O)N1CCC(c2coc3c(On4nnc5ccccc54)ncnc23)CC1.Oc1ccc(-n2cnnn2)cc1>>CC(C)(C)OC(=O)N1CCC(c2coc3c(Oc4ccc(-n5cnnn5)cc4)ncnc23)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070191333A1,CC(c1ccccc1)N1CCC(C(=O)N(Cc2ccccc2)Cc2ccccc2)C1.CC[Mg]Br>>CC(c1ccccc1)N1CCC(C2(N(Cc3ccccc3)Cc3ccccc3)CC2)C1,CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C,C1CCOC1,C1CCOC1,,,val
US20090069337A1,BrCCOc1c(Br)cccc1Br.NC(=O)CCC(=O)NCl.O=S=O>>O=S(=O)(Cl)c1ccc2c(c1)OCC2,,C1CCOC1,ClCCl,[Li]CCCC,,val
US20040138277A1,CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccc(C2CCCCC2)cc1.Cc1ccc(S(=O)(=O)OCCc2nc(-c3cccc(-c4cccs4)c3)oc2C)cc1>>Cc1oc(-c2cccc(-c3cccs3)c2)nc1CCOc1ccc(CC(C)(Oc2ccc(C3CCCCC3)cc2)C(=O)O)cc1,,CCO,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20130059846A1,Cc1ccc(-c2noc([C@H]3C[C@@H]3F)n2)cc1N.O=C(O)c1cnc2ccccn12>>Cc1ccc(-c2noc([C@H]3C[C@@H]3F)n2)cc1NC(=O)c1cnc2ccccn12,,ClCCl,c1ccncc1,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20150031833A1,CC(Br)OCCOCCOC(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1c[nH]c2ccccc12>>O=Cc1cn(CCOCCOCCOC(c2ccccc2)(c2ccccc2)c2ccccc2)c2ccccc12,,C1CCOC1,ClCCl,CCOC(C)=O,[H-].[Na+],val
US05714606,CCN(CC)CC.CCOC(=O)C(F)(F)F.NCC(=O)O>>CC[NH+](CC)CC.O=C([O-])CNC(=O)C(F)(F)F,,CO,,,,val
US20040147612A1,NO.O=C1CCCC1c1ccccc1>>ON=C1CCCC1c1ccccc1,,CCO,O,Cl,[Na+].[OH-],val
US05055482,N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)cc1O.O=C1CCC(=O)N1Br>>N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(Br)c1O,,ClC(Cl)Cl,,,,val
US20080200451A1,Cc1ccc2nc(-c3ccccc3)c(CC(=O)O)cc2c1>>Cc1ccc2c(c1)CC(CC(=O)O)C(c1ccccc1)N2,[Ni],CO,,[H][H],,val
US05739116,CC(=O)c1ccc2c(c1)N(CCCCCCO[Si](C)(C)C(C)(C)C)c1ccccc1S2>>CC(=O)c1ccc2c(c1)N(CCCCCCO)c1ccccc1S2,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04298739,CC(C)I.NC1CCCCC1O>>CC(C)NC1CCCCC1O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060189663A1,COc1ccc(NC2=C(c3ccccc3)C(=O)NC2=O)cc1.OCc1ccncc1>>COc1ccc(NC2=C(c3ccccc3)C(=O)N(Cc3ccncc3)C2=O)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05169769,CCOC(=O)C=NCl.Cc1ccc(C)c(O)c1N.ClCCl>>Cc1ccc(C)c2oc(CCl)nc12,,ClCCl,,Cl,,val
US06403614B1,C=O.NC(=O)c1ccccc1>>O=C(NCO)c1ccccc1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20140073620A1,CC(C)(C)OC(=O)N1CC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4C4(C(N)=O)CC4)n3)cc2)C1>>NC(=O)C1(c2ccccc2CCc2nc(Nc3ccc(C4CNC4)cc3)ncc2C(F)(F)F)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.O=C(c1ccccc1)c1nc2ccccc2cc1O>>COc1cc2nccc(Oc3cc4ccccc4nc3C(=O)c3ccccc3)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,,,val
US20140275071A1,CC(O)CCn1c(=O)c2c(nc(Br)n2Cc2ccc(Cl)cc2)n(C)c1=O.CCCS>>CCCSc1nc2c(c(=O)n(CCC(C)O)c(=O)n2C)n1Cc1ccc(Cl)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130137661A1,CC(C)(C)OC(=O)N[C@@H](Cn1c(=O)c([N+](=O)[O-])cn(Cc2c(F)cccc2F)c1=O)c1ccccc1>>CC(C)(C)OC(=O)N[C@@H](Cn1c(=O)c(N)cn(Cc2c(F)cccc2F)c1=O)c1ccccc1,[Pd],CO,,[H][H],,val
US20090075989A1,Nc1ccc2c(c1)COC2=O.O=C(O)C(=O)c1ccccc1>>O=C(Nc1ccc2c(c1)COC2=O)C(=O)c1ccccc1,,CC(=O)N(C)C,,O=S(Cl)Cl,,val
US20100121048A1,CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)[C@H](CO)C1.Oc1ccc(C(F)(F)F)cc1>>CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)[C@H](COc2ccc(C(F)(F)F)cc2)C1,,Cc1ccccc1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04900751,COc1ccc(N)c(Sc2nc3cc(OC)c(OC)cc3[nH]2)c1.c1ccncc1>>COc1ccc(-c2ccccn2)c(Sc2nc3cc(OC)c(OC)cc3[nH]2)c1,,O,,Cl,O=N[O-].[Na+],val
US20160039814A1,CC(C(=O)O)N(C)C(=O)OC(C)(C)C.CC(C)[Si](C#Cc1nc(N)ccc1Br)(C(C)C)C(C)C>>CC(C(=O)Nc1ccc(Br)c(C#C[Si](C(C)C)(C(C)C)C(C)C)n1)N(C)C(=O)OC(C)(C)C,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05204462,COC(=O)[C@@H]1CCCN1.O=C(Cl)C=Cc1ccccc1>>COC(=O)[C@@H]1CCCN1C(=O)C=Cc1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US05028738,CI.COC(=O)C(=O)Cc1ccc(C(=O)OC)cc1>>CC(C(=O)C(=O)O)c1ccc(C(=O)O)cc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US05994270,CCN=C=O.c1ccc2[nH]ccc2c1>>CCNC(=O)n1ccc2ccccc21,,C1CCOC1,,[H-].[Na+],,val
US20090091243A1,Cc1c(C#CCO)cnc(F)c1C>>C#Cc1ccc(F)nc1,,Cc1ccccc1,,[Na+].[OH-],,val
US20080293940A1,C1CCNC1.Cc1ccc(S(=O)(=O)O[C@@H]2CCN(Cc3ccccc3)C2)cc1>>c1ccc(CN2CC[C@H](N3CCCC3)C2)cc1,,CCO,,,,val
US20040209931A1,Cc1oc(-c2ccccc2)nc1CO[C@@H]1CCC[C@H](O)C1>>Cc1oc(-c2ccccc2)nc1CO[C@H]1CCC[C@@H](O)C1,,CO,,CC(=O)O,C[O-].[Na+],val
US05453500,CC(=O)O[C@H]1C=C[C@@](C)(OCC2=CC=C(CO[C@]3(C)C=C[C@H](OC(C)=O)[C@@H](C(=O)[O-])O3)SS2)O[C@@H]1C(=O)[O-].OCC1=CC=C(CO)SS1>>OC[C@H]1O[C@H](OCC2=CC=C(CO[C@@H]3C=C[C@H](O)[C@@H](CO)O3)SS2)C=C[C@@H]1O,,C1CCOC1,,[Na+].[OH-],,val
US20140155407A1,N#Cc1ncccc1CBr.c1c[nH]cn1>>N#Cc1ncccc1Cn1ccnc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US07319104B2,CC(C)c1nc(-c2ccc(C=O)cc2)no1.COC(=O)C(C)(C)Oc1ccc(CCN)cc1>>COC(=O)C(C)(C)Oc1ccc(CCNCc2ccc(-c3noc(C(C)C)n3)cc2)cc1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040225111A1,CC(C)(C)OC(=O)[C@H](Cc1ccc(OCCCC(=O)NC2=NCCCN2)cc1)Nc1nc2cc(Br)cc(F)c2o1>>O=C(CCCOc1ccc(C[C@H](Nc2nc3cc(Br)cc(F)c3o2)C(=O)O)cc1)NC1=NCCCN1,,ClCCl,,Cc1ccccc1,O=C(O)C(F)(F)F,val
US20160076063A1,CCCC/C=C\CCCCCCCCC[C@@H](C)OC(=O)c1ccccc1>>CCCC/C=C\CCCCCCCCC[C@@H](C)O,,CO,,[Na+].[OH-],,val
US20130310380A1,Cc1occc1-c1cncc(N2C[C@H](C)O[C@H](C)C2)n1.O=C1CCC(=O)N1Br>>Cc1occc1-c1nc(N2C[C@H](C)O[C@H](C)C2)cnc1Br,,ClC(Cl)Cl,,,,val
US20120071669A1,Brc1ccc2[nH]ccc2c1.CC[Mg]Br>>[Br-].[Br-].[Mg+2].c1ccc2[nH]ccc2c1,,CCOCC,,,,val
US20080058384A1,COC(=O)C1=C(C)NC(=O)CC1c1ccc(C(F)(F)F)cc1F.COS(=O)(=O)OC>>COC(=O)C1=C(C)N(C)C(=O)CC1c1ccc(C(F)(F)F)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(Oc3cnccn3)cc(Cl)c21>>O=C(O)CC1OB(O)c2cc(Oc3cnccn3)cc(Cl)c21,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20100311966A1,CCOC(=O)c1sc(N2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)[C@H](OC)C2)nc1CO>>CCOC(=O)c1sc(N2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)[C@H](OC)C2)nc1C=O,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20060135593A1,COC(=O)Cc1cccc(O)c1.Cc1oc(-c2ccccc2)nc1CCl>>COC(=O)Cc1cccc(OCc2nc(-c3ccccc3)oc2C)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20130085140A1,O=C(O)Cc1ccccc1C(=O)O>>O=C1Cc2ccccc2C(=O)O1,,Cc1ccccc1,,CC(=O)OC(C)=O,,val
US20110152273A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)cc3c2C(=O)NC3)c1>>Cc1cccc(Nc2nc(N[C@@H]3CCOC[C@@H]3NC(=O)OC(C)(C)C)cc3c2C(=O)NC3)c1,,ClCCl,,CCN(CC)CC,,val
US20100216762A1,CC(O)c1ccccc1.N#Cc1ccc(O)cc1>>CC(Oc1ccc(C#N)cc1)c1ccccc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040127574A1,CCOC(=O)C(Cc1cccc(SC(F)(F)F)c1)C(O)c1ccc(F)cc1>>O=C(O)C(Cc1cccc(SC(F)(F)F)c1)C(O)c1ccc(F)cc1,,CO,,[Na+].[OH-],,val
US20090156600A1,COC(=O)CBr.Cc1nc2c(Cl)ccc(O)c2c(C)c1Cc1ccc(S(C)(=O)=O)cc1>>COC(=O)COc1ccc(Cl)c2nc(C)c(Cc3ccc(S(C)(=O)=O)cc3)c(C)c12,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050282875A1,CN1CC[C@H](O)C1.COC(=O)C(O)(c1cccs1)c1cccs1>>CN1CC[C@H](OC(=O)C(O)(c2cccs2)c2cccs2)C1,,Cc1ccccc1,,,,val
US05814648,CC(C)(C)[Si](C)(C)OCCOc1cccc(C2=N[C@H](c3ccccc3)CO2)c1>>OCCOc1cccc(C2=N[C@H](c3ccccc3)CO2)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20030216362A1,O=C1c2ccccc2C(=O)N1CCCc1cnccn1>>NCCCc1cnccn1,,ClC(Cl)Cl,,NN,,val
US20150152108A1,CC1CNCCN1Cc1ccccc1.O=C(Nc1cnccn1)N1c2nc(Cl)ccc2N2CC[C@H]1C2>>CC1CN(c2ccc3c(n2)N(C(=O)Nc2cnccn2)[C@H]2CCN3C2)CCN1Cc1ccccc1,,C1COCCO1,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05883090,COC(=O)C(c1ccc2c(c1)OCO2)n1nc(C)cc(C)c1=O>>Cc1cc(C)c(=O)n(C(C(=O)O)c2ccc3c(c2)OCO3)n1,,CO,,[Na+].[OH-],,val
US20090286801A1,CC(=O)CN1CCC(CCN2CCN(c3cccc(N)c3)CC2)CC1.CCOC(=O)Cl>>CCOC(=O)Nc1cccc(N2CCN(CCC3CCN(CC(C)=O)CC3)CC2)c1,,ClCCl,,CCN(CC)CC,,val
US04492693,CC(=O)c1csc2ccccc12.O=[Se]=O>>O=C(O)C(O)c1csc2ccccc12,,c1ccncc1,,O,,val
US20020013496A1,COc1ccc(CBr)cc1.Fc1c(F)c(F)c(S)c(F)c1F.O=C(OO)c1cccc(Cl)c1>>COc1ccc(CS(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)cc1,,CN(C)C=O,ClCCl,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20100261698A1,Nc1cncc(Br)c1.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1c1cncc(Br)c1,,CC(=O)O,,,,val
US20160068559A1,CC(C)(C)c1ccc2[nH]c(Cl)nc2c1.CN(CCCN)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21>>CN(CCCNc1nc2ccc(C(C)(C)C)cc2[nH]1)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21,,CCCCO,,,,val
US20120190649A1,COC(=O)C1CN(Cc2ccc3cc(O)ccc3c2)C1.OC1CCC(C(F)(F)F)CC1>>COC(=O)C1CN(Cc2ccc3cc(OC4CCC(C(F)(F)F)CC4)ccc3c2)C1,,Cc1ccccc1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090030038A1,C=O.CO.COc1ccc(NS(=O)(=O)c2ccccc2-c2ccc(Cl)cc2)c2c1C[C@@H](N)CC2>>COc1ccc(NS(=O)(=O)c2ccccc2-c2ccc(Cl)cc2)c2c1C[C@@H](N(C)C)CC2,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US06229048B1,CC(=O)O.CC(=O)Oc1cc(OC(C)=O)c2c(c1)C(=O)c1cc(C)ccc1C2=O>>CC(=O)Oc1cc(OC(C)=O)c2c(c1)C(=O)c1cc(C(=O)O)ccc1C2=O,,CC(=O)OC(C)=O,,O,,val
US20120172393A1,OC1(c2ccccc2Cl)CC2CCC(C1)N2Cc1ccccc1>>OC1(c2ccccc2Cl)CC2CCC(C1)N2,,CO,,CC(Cl)OC(=O)Cl,,val
US20030236280A1,NC1CCc2cc(F)ccc2C1CC1CC1.O=C(Nc1cccc2cnccc12)Oc1ccccc1>>O=C(Nc1cccc2cnccc12)NC1CCc2cc(F)ccc2C1CC1CC1,,CS(C)=O,,CCN(C(C)C)C(C)C,Cl,val
US20090318486A1,COC(=O)CN1C(=O)C(C#N)(C(C#N)C(=O)OC)c2cc(Cl)ccc21>>COC(=O)CN1C(=O)C2(CC(=O)NC2=O)c2cc(Cl)ccc21,,CCOC(C)=O,,CO,,val
US20080255149A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2cc(F)ccc2C(F)(F)F)CC1>>O=C(c1cc(F)ccc1C(F)(F)F)N1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050085515A1,ClCCl.O=C(O)C=Cc1cccc(S(=O)(=O)NCc2ccc3c(c2)OCO3)c1>>O=C(Cl)C=Cc1cccc(S(=O)(=O)NCc2ccc3c(c2)OCO3)c1,CN(C)C=O,,,,,val
US20140235439A1,NC(=NO)c1ccc(Cl)cc1.O=Cc1ccco1>>Clc1ccc(C2=NOC(c3ccco3)N2)cc1,C1CCNCC1,Cc1ccccc1,,,,val
US20050154042A1,CC(C)N.CCOC(=O)CBr>>CCOC(=O)CNC(C)C,,Cc1ccccc1,,,,val
US20080275046A1,COC(=O)c1sc(-c2ccc(OCCCCl)cc2)nc1C.O=C1CCC(=O)N1Br>>COC(=O)c1sc(-c2ccc(OCCCCl)c(Br)c2)nc1C,,CC#N,,,,val
US05021421,O=C(O)c1ccco1.c1ccc(-c2cc(N3CCNCC3)nc3c2CCCC3)cc1>>O=C(c1ccco1)N1CCN(c2cc(-c3ccccc3)c3c(n2)CCCC3)CC1,,ClC(Cl)Cl,,CCN=C=NCCCN(C)C,Cl,val
US20130336920A1,COCCNCCOC.O=C(NCc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(F)ccc2[N+](=O)[O-])c1>>COCCN(CCOC)c1ccc([N+](=O)[O-])c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20030055263A1,Nc1nnc(-c2ccc3ccccc3c2)s1.O=C1OC(=O)c2ccccc21>>O=C(O)c1ccccc1C(=O)Nc1nnc(-c2ccc3ccccc3c2)s1,,c1ccncc1,,,,val
US05565606,CI.O=C(O)COc1ccc(CO)cc1>>COC(=O)COc1ccc(CO)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20110190342A1,N[C@@H](Cc1ccc(Oc2ncc(Cl)cc2Cl)cc1)C(=O)O.O=C(O)c1cc2cc(Cl)ccc2nc1Cl>>O=C(O)c1cc2cc(Cl)ccc2nc1N[C@@H](Cc1ccc(Oc2ncc(Cl)cc2Cl)cc1)C(=O)O,,CS(C)=O,,,,val
US20110028492A1,BrCCCCBr.N[C@@H]1CC[C@@H](Nc2cc(-c3cnc(Cl)c(NCC4CCOCC4)n3)c(Cl)cn2)CC1>>Clc1cnc(N[C@@H]2CC[C@@H](N3CCCC3)CC2)cc1-c1cnc(Cl)c(NCC2CCOCC2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140336190A1,Cc1n[nH]c(-c2ccccc2)c1Br.Cc1noc(C)c1-c1cc(B2OC(C)(C)C(C)(C)O2)c2[nH]c(C3CC3)nc2c1>>Cc1n[nH]c(-c2ccccc2)c1-c1cc(-c2c(C)noc2C)cc2[nH]c(C3CC3)nc12,,O,,COCCOC,O=C([O-])[O-].[Cs+].[Cs+],val
US04195099,CC(C)CBr.CC1=CCC(C=O)CC1.CCOCC.[Mg]>>CC(C)CC1OC2(C)CCC1CC2.CC(C)C[Mg]Br,,CCOCC,,O=S(=O)(O)O,,val
US20100317680A1,CN1CCC(O)CC1.O=[N+]([O-])c1cn[nH]c1>>CN1CCC(n2cc([N+](=O)[O-])cn2)CC1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05959057,COC(=O)CCc1cc(C(C)(C)C)cc(C(C)(C)C)c1O>>CC(C)(C)c1cc(CCC(=O)O)c(O)c(C(C)(C)C)c1,,CCO,,[Na+].[OH-],,val
US06599917B1,COc1cc(Cc2ccccc2)c(Br)cn1>>Oc1cc(Cc2ccccc2)c(Br)cn1,,Br,,O=C([O-])[O-].[K+].[K+],,val
US04661636,CC(C)(C)c1cc(CNC(=O)CCl)c(O)c(S(C)(=O)=O)c1.Cl>>CC(C)(C)c1cc(CN)c(O)c(S(C)(=O)=O)c1.Cl,,CCO,Cl,,,val
US20110166182A1,COc1ccc2c(c1)CCC(C(=O)O)=C2Oc1ccc(OCCN2CCCCC2)cc1.O=C1CCC(=O)N1Br>>COc1ccc2c(c1)CCC(Br)=C2Oc1ccc(OCCN2CCCCC2)cc1,,ClCCl,,CCN(CC)CC,,val
US04973699,O=C(O)C(=NOC1CC1)c1nsc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>Nc1nc(C(=NOC2CC2)C(=O)O)ns1,,COc1ccccc1,,O=C(O)C(F)(F)F,,val
US20120041009A1,Cc1cccc(-c2cc(C(N)=NO)nc(C)n2)c1.O=C(n1ccnc1)n1ccnc1>>Cc1cccc(-c2cc(-c3nc(=O)o[nH]3)nc(C)n2)c1,,C1CCOC1,O,C1CCC2=NCCCN2CC1,Cl,val
US20110312921A1,Cc1nn(C)c(CC(C)C)c1N.O=S(=O)(Cl)c1c(Cl)cc(Br)cc1Cl>>Cc1nn(C)c(CC(C)C)c1NS(=O)(=O)c1c(Cl)cc(Br)cc1Cl,,c1ccncc1,,,,val
US20080139588A1,CC(=O)Cl.CC(Nc1ncc2cc(C(O)c3ccccc3Cl)n(-c3c(F)cccc3F)c2n1)C(C)(C)O>>CC(=O)OC(c1ccccc1Cl)c1cc2cnc(NC(C)C(C)(C)O)nc2n1-c1c(F)cccc1F,,c1ccncc1,,CCN(CC)CC,CCOC(C)=O,val
US20080090801A1,COc1ccc(B(O)O)cn1.Cc1nc(N)nc2c1cc(Br)c(=O)n2[C@@H]1CC[C@@H](O)CC1>>COc1ccc(-c2cc3c(C)nc(N)nc3n([C@@H]3CC[C@@H](O)CC3)c2=O)cn1,Cl[Pd]Cl,,,O=C([O-])[O-].[K+].[K+],,val
US20090036492A1,COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.O=Cc1cccc(F)c1>>COc1cc(O)c2c(c1C(=O)NCc1ccccc1F)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,,Cc1ccccc1,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20130253029A1,CC(C)(C)OC(=O)N1CC2C(C=NO)C2(c2ccc(Cl)c(Cl)c2)C1.CCI>>CCON=CC1C2CN(C(=O)OC(C)(C)C)CC12c1ccc(Cl)c(Cl)c1,,CN(C)C=O,,[H-].[Na+],,val
US20040147562A1,NNC(=O)c1cccnc1.O=C(CC(=O)C(F)(F)F)c1ccc(Br)cc1>>O=C(c1cccnc1)n1nc(-c2ccc(Br)cc2)cc1C(F)(F)F,,CCO,,,,val
US20030153778A1,C[Si](C)(C)Cl.FC(F)(Br)Sc1ccccc1>>C[Si](C)(C)C(F)(F)Sc1ccccc1,,CN(C)C=O,,,,val
US05420275,CC(=O)c1ccc(O)cc1.COS(=O)(=O)OC>>COc1ccc(C(C)=O)cc1,,CCO,O,[Na+].[OH-],,val
US20050148659A1,CC1(C)Oc2ccc(CC(=O)NCc3ccccc3)cc2C2OC21.N>>CC1(C)Oc2ccc(CC(=O)NCc3ccccc3)cc2C(N)C1O,,CCO,,O,,val
US20050176717A1,Cc1ccc(C(=O)N(CCCNC(=O)OC(C)(C)C)C(c2nc3ccccc3nc2Cc2ccccc2)C2CC2)cc1.Cl>>Cc1ccc(C(=O)N(CCCN)C(c2nc3ccccc3nc2Cc2ccccc2)C2CC2)cc1.Cl,,C1COCCO1,,CCOCC,,val
US20070060767A1,CCNN(NCC)C(=O)CC#N.CCOc1cc(C=O)cc([N+](=O)[O-])c1O>>CCOc1cc(C=C(C#N)C(=O)N(CC)CC)cc([N+](=O)[O-])c1O,,Cc1ccccc1,O,C1CCNCC1,CC(=O)O,val
US03943141,CCOc1ccc2c(=O)c(C(=O)O)cn(CCOC=O)c2n1.Nc1nnn[nH]1>>CCOc1ccc2c(=O)c(C(=O)Nc3nnn[nH]3)cn(CCO)c2n1,,CN(C)C=O,,,,val
US20100249123A1,CC(C)(CC#N)c1ccc(N)cc1.COc1ccc(C(=O)Cl)cc1OC>>COc1ccc(C(=O)Nc2ccc(C(C)(C)CC#N)cc2)cc1OC,,ClCCl,,CCN(CC)CC,,val
US20020119909A1,CC(C)[Mg]Cl.c1ccc(C[C@@H]2CO2)cc1>>CC(C)C[C@H](O)Cc1ccccc1,[Cu]I,C1CCOC1,,,,val
US05308853,CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1.Cc1nc(CCl)cs1.Cl>>CCCCc1ncc(/C=C2\C(=O)N(Cc3csc(C)n3)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1.Cl.Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130217666A1,COC(=O)c1nc2n(c1C=O)C1CC(C1)c1cc(F)c(Br)cc1-2>>O=Cc1c(C(=O)O)nc2n1C1CC(C1)c1cc(F)c(Br)cc1-2,,CO,O,[Li+].[OH-],,val
US20100210680A1,C=Cc1ccc(Cl)c2c1[C@@H]1CNC[C@]1(C)OC2.Cl>>CCc1ccc(Cl)c2c1[C@@H]1CNC[C@]1(C)OC2.Cl,[Pd],CCO,,,,val
US20070129334A1,ClCl.O=[N+]([O-])c1cnccc1O>>O=[N+]([O-])c1cnccc1Cl,,CC(=O)O,,,,val
US20030199564A1,CCOC(=O)C=C(C)c1ccc(NC(C)=O)c2c1CCC2>>CCOC(=O)CC(C)c1ccc(NC(C)=O)c2c1CCC2,[Pd],CCO,,,,val
US20110263651A1,CC(C)(C)OC(=O)N1CCC(CCCC(=O)Nc2ccc(Cl)c(Cl)c2)CC1.CCI>>CCN(C(=O)CCCC1CCN(C(=O)OC(C)(C)C)CC1)c1ccc(Cl)c(Cl)c1,,C1CCOC1,,[H-].[Na+],,val
US20030181719A1,CCc1cc(Nc2cc(=O)n(CCCCO)c(=O)[nH]2)ccc1C.C[Si](C)(C)I>>CCc1cc(Nc2cc(=O)n(CCCCI)c(=O)[nH]2)ccc1C,,ClC(Cl)Cl,,O=S([O-])[O-].[Na+].[Na+],,val
US20080167371A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)CCNCc1ccc(Br)cc1Cl>>CC(C)CCN(Cc1ccc(Br)cc1Cl)C(=O)OC(C)(C)C,,CCOC(C)=O,O,O=C([O-])O.[Na+],,val
US20110028461A1,O=C(O)Cn1nc(Cl)ccc1=O>>O=C(O)Cn1ncccc1=O,[Pd],CO,,,,val
US20090312321A1,CCN.CCONC(=O)c1cc(NCc2cnc(Cl)nc2Cl)cc(OC)c1>>CCNc1nc(Cl)ncc1CNc1cc(OC)cc(C(=O)NOCC)c1,,C1CCOC1,,,,val
US05280039,COC(=O)c1ccc(CCBr)c(OC)c1.O=[N+]([O-])c1ccc2[nH]ccc2c1>>COC(=O)c1ccc(Cc2c[nH]c3ccc([N+](=O)[O-])cc23)c(OC)c1,O=[Ag],C1COCCO1,,,,val
US20090274632A1,Cc1noc(C)c1Cn1cc(N)cn1.O=C=NCc1ccccc1>>Cc1noc(C)c1Cn1cc(NC(=O)NCc2ccccc2)cn1,,CC#N,,,,val
US20100009970A1,COC(=O)c1cc(S(N)(=O)=O)ccc1Oc1ccc(SC)c(C)c1>>CSc1ccc(Oc2ccc(S(N)(=O)=O)cc2CO)cc1C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160221994A1,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=CC1Cc2cc(Br)cc(Cl)c2O1>>CCOC(=O)/C=C/C1Cc2cc(Br)cc(Cl)c2O1,,Cc1ccccc1,,O,,val
US20070049560A1,Cl.O=C(O)CN1CCCC1>>Cl.O=C(O)CN1CCCC1,,COC(C)(C)C,,CC#N,,val
US05106861,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOCC(O)(COCC)C(N)Cc1cccc2ccccc12>>CCOCC(O)(COCC)C(Cc1cccc2ccccc12)NC(=O)OC(C)(C)C,,CO,,,,val
US20060025459A1,COC(=O)c1cc(OCCCOCc2ccccc2)cc(N2CCCC2=O)c1>>COC(=O)c1cc(OCCCO)cc(N2CCCC2=O)c1,[Pd],CO,,,,val
US20050165063A1,CCCN(CCC)CCCCNC(=O)c1ccc(CN(Cc2ncc[nH]2)C(=O)OC(C)(C)C)cc1.O=Cc1ccccn1>>CCCN(CCC)CCCCNC(=O)c1ccc(CN(Cc2ccccn2)Cc2ncc[nH]2)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20100261728A1,FC(F)(F)c1ccc([C@H]2NCCc3ccccc32)cc1.O=C(O)C1(C(F)(F)F)CC1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>O=C(NC1(C(F)(F)F)CC1)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20050245563A1,CC(=O)c1c(O)c2ccccc2n(CCNC(=O)OC(C)(C)C)c1=O.NN>>Cc1[nH]nc2c1c(=O)n(CCNC(=O)OC(C)(C)C)c1ccccc21,,CN(C)C=O,,O,,val
US20060041003A1,CCCCC12CC(=O)C=C1c1ccc(O)cc1C2.COCCl>>CCCCC12CC(=O)C=C1c1ccc(OCOC)cc1C2,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20080249093A1,CO.O=C(O)c1ccc(O)c(Br)c1>>COC(=O)c1ccc(O)c(Br)c1,,CO,ClCCl,C[Si](C)(C)C=[N+]=[N-],,val
US20140221345A1,COc1ccccc1N1CCOCC1>>Oc1ccccc1N1CCOCC1,,ClCCl,,BrB(Br)Br,,val
US20130029954A1,C=C(C)[C@@H]1CC[C@]2(CNCCNC(C)=O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC(C)(C)C)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(CNCCNC(C)=O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120116116A1,CC=CC=CCCC(=O)OCC>>CC=CC=CCCC(=O)O,,CCCCCCC,,Cl,[K+].[OH-],val
US06426357B1,Br.N[C@H](CC(=O)O)C(=O)O>>O=C(O)C[C@@H](Br)C(=O)O,,CCOCC,O,O=N[O-].[Na+],,val
US20090270390A1,CC(C)(C)OC(=O)N1C2CCC1CNC2.CN(C)C=O.FC(F)c1nc2ccccc2n1-c1nc(Cl)cc(N2CCOCC2)n1>>NCC(=O)N1C2CCC1CN(c1cc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n1)C2,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US05155122,CC(C)(C)c1cc(-c2nnc(N)s2)cc(C(C)(C)C)c1O.CCOC(=O)N=C=S>>CCOC(=O)NC(=S)Nc1nnc(-c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)s1,,C1CCOC1,,,,val
US20130296301A1,CN(C)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)S1.CS(=O)(=O)Cl>>CN(C)C1=N[C@H]2[C@H](O[C@H](COS(C)(=O)=O)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)S1,,ClCCl,,CCN(CC)CC,,val
US20120264748A1,Cc1ccc(C)c(CCl)c1.O=C1CCCC2(CCN(c3cnc4ccccc4n3)CC2)N1>>Cc1ccc(C)c(CN2C(=O)CCCC23CCN(c2cnc4ccccc4n2)CC3)c1,,[Cl-],[NH4+],C1CCOC1,,val
US05308843,CCCC[Sn](Cl)(CCCC)CCCC.CCc1cc(Br)cc(C)n1>>CCCC[Sn](CCCC)(CCCC)c1cc(C)nc(CC)c1,,CCOCC,,O,[Li]CCCC,val
US20060135541A1,COc1cc2c(=O)n(CC(=O)OC(C)(C)C)cnc2cc1OCCCO>>COc1cc2c(=O)[nH]cnc2cc1OCCCO,,CO,,[Na+].[OH-],,val
US20060293319A1,O=C1Nc2cc(Cl)ccc2C1(Cc1cccc(Cl)c1)C1CCCNC1.O=C=Nc1cccc(Cl)c1>>O=C(Nc1cccc(Cl)c1)N1CCCC(C2(Cc3cccc(Cl)c3)C(=O)Nc3cc(Cl)ccc32)C1,,ClCCl,,CCN(CC)CC,,val
US04539319,BrCc1ccccc1.Oc1cccc2c1CCCC2>>c1ccc(COc2cccc3c2CCCC3)cc1,,CC(C)=O,CCOCC,O=C([O-])[O-].[K+].[K+],,val
US20160229844A1,NC1CC1.O=C(O)CC1CCc2cc(C(O)(C(F)(F)F)C(F)(F)F)ccc2N1S(=O)(=O)c1ccc(F)cc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>O=C(NCC1CCc2cc(C(O)(C(F)(F)F)C(F)(F)F)ccc2N1S(=O)(=O)c1ccc(F)cc1)NC1CC1,,Cc1ccccc1,,CCN(CC)CC,,val
US05998624,CN.O=C(O)c1cc2ccccc2c(-c2ccccc2I)n1>>CNC(=O)c1cc2ccccc2c(-c2ccccc2I)n1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20050261358A1,CN(C)C1(c2ccccc2)CCC(CN)CC1.O=C(NCCCc1ccccc1)Oc1ccccc1>>CN(C)C1(c2ccccc2)CCC(CNC(=O)NCCCc2ccccc2)CC1,,C1COCCO1,,,,val
US20120142647A1,CCCNc1nc(N)nc(Cl)n1.CNOC>>CCCNc1nc(N)nc(N(C)OC)n1,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20080234327A1,CCOC(=O)C1C(=O)CCc2ccccc21.Cc1ccc(NN)nc1>>Cc1ccc(-n2nc3c(c2O)-c2ccccc2CC3)nc1,,CC(=O)O,,,,val
US04144263,CCOC(OCC)C(C#N)(C=O)Cc1cc(OC)c(OC)c(OC)c1.N=C(N)N>>COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC,,CCO,,,,val
US20110071197A1,CC(=O)OC(C)=O.CO.Nc1ccc(O)cc1C(=O)O>>COC(=O)c1cc(O)ccc1NC(C)=O,,CO,,C[O-].[Na+],,val
US20090076046A1,O=S(=O)(c1ccccc1)n1cc(Cc2ccc(NCc3cnccc3Cl)nc2)c2cccnc21>>Clc1cnccc1CNc1ccc(Cc2c[nH]c3ncccc23)cn1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040166125A1,CC(C)=CCn1c(N2CCCC(NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(CC(=O)c1ccccc1NC=O)c(=O)n2C>>CC(C)=CCn1c(N2CCCC(N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1NC=O)c(=O)n2C,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20100063041A1,CC(=O)OC(C)=O.CC(NC(=O)c1ccc(Br)cc1)C(=O)O>>CC(=O)C(C)NC(=O)c1ccc(Br)cc1,,c1ccncc1,,,,val
US05643958,C[C@H](O)[C@@H](C/C=C/c1ccc2ccccc2c1)c1ccc(Cl)cc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCC(CC=Cc1ccc2ccccc2c1)c1ccc(Cl)cc1.[N-]=[N+]=[N-],,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040192698A1,CC(C)Nc1nc2ccc(CO)cc2n2c(=O)[nH]nc12>>Cc1ccc2nc(NC(C)C)c3n[nH]c(=O)n3c2c1,[Pd],CCO,,[H][H],,val
US05175162,Cc1cc2c(s1)SCCc1cc(=O)n(-c3ccc(Cl)cc3)nc1-2.OO>>Cc1cc2c(s1)S(=O)CCc1cc(=O)n(-c3ccc(Cl)cc3)nc1-2,,O=CO,,O,,val
US20040082542A1,O=[N+]([O-])c1ccc(Oc2ccc3ccccc3c2)cc1>>Nc1ccc(Oc2ccc3ccccc3c2)cc1,[Pd],CCO,,,,val
US20110319445A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCNCc1cc2ccccc2nc1Cl>>CCN(Cc1cc2ccccc2nc1Cl)C(=O)OC(C)(C)C,,ClCCl,,,,val
US20130143843A1,CCCCOc1ccc(C(C)(N)CC(=O)OC)cc1.N#CCC(=O)O>>CCCCOc1ccc(C(C)(CC(=O)OC)NC(=O)CC#N)cc1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20160264548A1,C/C=C/C(=O)Cl.NC(=O)c1cc(N2CCC(N)C2)cnc1Oc1ccc(Oc2ccccc2)cc1>>C/C=C/C(=O)NC1CCN(c2cnc(Oc3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100152160A1,CN(C)c1cc2c(cc1Cl)NCC(C(=O)N1CCC(C#N)(Cc3ccc(F)cc3)CC1)O2.N#CBr>>CN(C)c1cc2c(cc1Cl)N(C#N)CC(C(=O)N1CCC(C#N)(Cc3ccc(F)cc3)CC1)O2,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20080146636A1,Cc1ccc2c(c1)nc(C(C)(C)O)n2[C@@H]1CC[C@H](NCC2Cc3ccc(Cl)cc3C2)CC1>>Cc1ccc2c(c1)nc(C(C)(C)O)n2[C@@H]1CC[C@@H](NCC2Cc3ccc(Cl)cc3C2)CC1,,C1CCCCC1,,,,val
US20090099248A1,COC(=O)c1cc2c([nH]1)CCCC2=O.C[Si](C)(C)CCOCCl>>COC(=O)c1cc2c(n1COCC[Si](C)(C)C)CCCC2=O,,CN(C)C=O,,[H-].[Na+],,val
US20160194316A1,COc1c(CNC(=O)OC(C)(C)C)c(OCc2ccccc2)nn1C>>COc1c(CNC(=O)OC(C)(C)C)c(=O)[nH]n1C,[Pd],CO,,,,val
US05593993,COc1cccc(CCN)c1.S=C(Nc1nc2ccccc2s1)n1ccnc1>>COc1cccc(CCNC(=S)Nc2nc3ccccc3s2)c1,,CN(C)C=O,,,,val
US20020177578A1,O=C1CSC=C(c2ccccc2)C1.[NH4+]>>NC1=CC(c2ccccc2)=CSC1,,CO,,[BH3-]C#N.[Na+],,val
US20090270456A1,COC(=O)c1sc(Cl)nc1Cl.COc1ccc(B(O)O)cc1>>COC(=O)c1sc(-c2ccc(OC)cc2)nc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US05453464,CC(=O)CC(=O)OC(C)(C)C.CC(=O)CC(=O)[O-].Cc1ccccc1.O=C(Cl)c1ccc(C(=O)Cl)cc1>>CC(=O)C(C(=O)OC(C)(C)C)C(=O)c1ccc(C(=O)C(C(C)=O)C(=O)OC(C)(C)C)cc1,,Cc1ccccc1,,Cl,[Na+].[OH-],val
US20130225589A1,CCc1nc(SC)ncc1C(=O)O.Cc1ccc(O)c(N)c1C>>CCc1nc(SC)ncc1C(=O)Nc1c(C)cccc1O,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20040132727A1,COc1cc2nccc(Oc3ccc(NC(=O)COc4ccccc4C)cc3)c2cc1OC>>COc1cc2nccc(Oc3ccc(NCCOc4ccccc4C)cc3)c2cc1OC,,C1CCOC1,,Cl,[Na+].[OH-],val
US20160046649A1,CNCCOc1ccccc1C(C)(C)C.COC(=O)c1ccccc1N=C=O>>COC(=O)c1ccccc1NC(=O)N(C)CCOc1ccccc1C(C)(C)C,,ClCCl,O,CCN(CC)CC,Cl,val
US20020091134A1,COC(=O)c1cccc2[nH]ccc12>>OCc1cccc2[nH]ccc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060167248A1,Cc1cc([N+](=O)[O-])cc(Cl)c1N.O=C(Cl)CC1CCCC1>>Cc1cc([N+](=O)[O-])cc(Cl)c1NC(=O)CC1CCCC1,,CC#N,,,,val
US06846833B2,C=CC(N)=O.NCc1ccccn1>>NC(=O)CCNCc1ccccn1,,CN(C)C=O,,CCN(CC)CC,,val
US06878712B1,C[C@H]1CN[C@H](C)CN1C(=O)[C@@](C)(O)C(F)(F)F.O=S(=O)(Cl)c1ccc(F)cc1>>C[C@H]1CN(S(=O)(=O)c2ccc(F)cc2)[C@H](C)CN1C(=O)[C@@](C)(O)C(F)(F)F,,CCOC(C)=O,,CCN(CC)CC,,val
US20160106842A1,CCCCC/C=C\C/C=C\CCCCCCCCOc1cc(CN2C(=O)c3ccccc3C2=O)cc(OCCCCCCCC/C=C\C/C=C\CCCCC)c1>>CCCCC/C=C\C/C=C\CCCCCCCCOc1cc(CN)cc(OCCCCCCCC/C=C\C/C=C\CCCCC)c1,,CCO,,NN,,val
US20140228396A1,Br[Mg]C1CC1.C1CCOC1.CSC.Fc1cncc(Br)c1.O=C(Cl)Oc1ccccc1>>O=C(Oc1ccccc1)N1C=C(F)C(C2CC2)C(Br)=C1c1ccccc1,I[Cu]I,C1CCOC1,,,,val
US20090076070A1,C=CCCC(=O)Cl.N#Cc1cccc([N+](=O)[O-])c1N>>C=CCCC(=O)Nc1ccc(C#N)cc1[N+](=O)[O-],,C1CCOC1,,CCN(C(C)C)C(C)C,O,val
US20130261159A1,CCI.OCc1coc(CCl)n1>>CCOCc1coc(CCl)n1,,ClCCl,,N#N,,val
US20050154061A1,Cc1cc(CNC2CCCCC2)ccc1OCC(=O)OC(C)(C)C.O=C(CBr)Nc1ccc(Cl)cc1Cl>>Cc1cc(CN(CC(=O)Nc2ccc(Cl)cc2Cl)C2CCCCC2)ccc1OCC(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20150152108A1,Cc1ccc(-c2ccc3c(n2)N[C@H]2CCN3C2)cn1.NCC(F)(F)F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1ccc(-c2ccc3c(n2)N(C(=O)NCC(F)(F)F)[C@H]2CCN3C2)cn1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20110015196A1,CC(=O)N[C@@H]1C[C@H](C(=O)OCc2ccccc2)C1(C)C>>CC(=O)N[C@@H]1C[C@H](C(=O)O)C1(C)C,[Pd],CCOC(C)=O,,,,val
US20120093742A1,CCCC(N)CCC.CCOC(=O)C(=O)c1ccc2c(c1)OCO2>>CCCC(CCC)NC(=O)C(=O)c1ccc2c(c1)OCO2,,CCO,,,,val
US20150087646A1,COC(=O)c1ccc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)cc1>>O=C(O)c1ccc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)cc1,,C1CCOC1,O,[Na+].[OH-],,val
US05576321,ClCCCCCOc1cccc2[nH]ccc12.O=C(O)C(=O)O.c1ccc2cc(C3CCNCC3)ccc2c1>>O=C(O)C(=O)O.c1ccc2cc(C3CCN(CCCCCOc4cccc5[nH]ccc45)CC3)ccc2c1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20080269240A1,CNCCO.COC(=O)Cc1cccc(OCCCBr)c1>>COC(=O)Cc1cccc(OCCCN(C)CCO)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130102587A1,CNOC.O=C(Cl)C1CCOCC1>>CON(C)C(=O)C1CCOCC1,,ClCCl,,CN1CCOCC1,Cl,val
US20080021032A1,CC(C)(C)OC(=O)Nc1cccc(Cn2ccc(NC(=O)[C@H](CC3CCCC3)c3ccc(S(C)(=O)=O)c(Cl)c3)n2)c1>>CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(Cc3cccc(N)c3)n2)cc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050176789A1,Cc1ccc(C(=O)Cl)cc1.Nc1nc(-c2ccccc2)cs1>>Cc1ccc(C(=O)Nc2nc(-c3ccccc3)cs2)cc1,,c1ccncc1,,,,val
US20140243336A1,CSCCC(CO)NC(=O)OC(C)(C)C.O=C1NC(=O)c2ccccc21>>CSCCC(CN1C(=O)c2ccccc2C1=O)NC(=O)OC(C)(C)C,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060287363A1,C[C@@H]1C[C@H](Nc2cccc(NC(=O)c3ccc(F)cc3Cl)c2)CCN1C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)Cl)cc1>>C[C@@H]1C[C@H](Nc2cccc(NC(=O)c3ccc(F)cc3Cl)c2)CCN1.Cl,,CO,Cc1ccccc1,[Cl-].[NH4+],,val
US20090042890A1,CCOC(=O)c1nc(N[C@H]2CCN(C(=O)OC(C)(C)C)C2)nc2c1[nH]c(=O)n2-c1ccccc1OC.CCOC(=O)c1nc(N[C@H]2CCNC2)nc2c1[nH]c(=O)n2-c1ccccc1OC>>COc1ccccc1-n1c(=O)[nH]c2c(C(N)=O)nc(N[C@H]3CCNC3)nc21,,ClCCl,O=C(O)C(F)(F)F,,,val
US20110076230A1,CN.Fc1ccc2[nH]c(-c3ccc(F)nc3)cc2c1>>CNc1ccc(-c2cc3cc(F)ccc3[nH]2)cn1,,CO,,,,val
US05283251,BrCc1ccccc1.O=C(O)CCCc1c[nH]c2ccccc12>>O=C(CCCc1c[nH]c2ccccc12)OCc1ccccc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20080234237A1,CN(CCCN1CCCc2cc([N+](=O)[O-])ccc21)C(=O)Oc1ccccc1>>CN(CCCN1CCCc2cc(N)ccc21)C(=O)Oc1ccccc1,[Pd],C1CCOC1,CCO,,,val
US20030004181A1,CCOC(=O)Cl.COC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C)c1ccccc1>>CCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OC)c4ccccc4)ccc3n2C)cc1,,CCO,ClCCl,Cl,,val
US20080293684A1,Cc1c(OCCCCBr)ccc(C(=O)CC(C)C)c1O.Oc1cccnc1Cl>>Cc1c(OCCCCOc2cccnc2Cl)ccc(C(=O)CC(C)C)c1O,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100273744A1,Nc1ccn(Cc2ccc(Cl)cc2C(F)(F)F)n1.O=C(O)c1ccncc1F>>O=C(Nc1ccn(Cc2ccc(Cl)cc2C(F)(F)F)n1)c1ccncc1F,,CN(C)C=O,CO,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04897405,N#CCc1cccc2c(Cl)cccc12.NO>>NC(Cc1cccc2c(Cl)cccc12)=NO,,CO,,Cl,C[O-].[Na+],val
US20150232460A1,CCc1nc(C(F)(F)F)cnc1N[C@H]1CCC[C@@H]1NC(=O)OC(C)(C)C.Cl>>CCc1nc(C(F)(F)F)cnc1N[C@H]1CCC[C@@H]1N.Cl,,C1COCCO1,,,,val
US20080171769A1,COc1nccc(NC[C@@H](O)c2cccc(Cl)c2)c1C1OCCO1>>O=Cc1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O,,C1COCCO1,,Cl,O,val
US20020025960A1,CN1c2sccc2C(=O)CS1(=O)=O.II>>CN1c2sc(I)cc2C(=O)CS1(=O)=O,,ClC(Cl)Cl,,,,val
US20020049329A1,BrBr.CC(=O)C1(c2ccccc2)CCNCC1>>Br.O=C(CBr)C1(c2ccccc2)CCNCC1,,ClCCl,,CCOCC,Cl,val
US20060074087A1,CC(C)(C)OC(=O)N1CCc2nc(C(F)(F)F)ncc2C1>>FC(F)(F)c1ncc2c(n1)CCNC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150152096A1,CCOC(=O)CNC(=O)C1COCCN1CC1=C(C(=O)OCC)C(c2ccc(F)cc2Br)N=C(c2nccs2)N1>>CCOC(=O)C1=C(CN2CCOCC2C(=O)NCC(=O)O)NC(c2nccs2)=NC1c1ccc(F)cc1Br,,CCO,O,[Na+].[OH-],,val
US04931444,COc1ccc(N2CCN(c3ccc(NC(N)=S)cc3)CC2)cc1.O=C(CCl)c1ccccc1>>COc1ccc(N2CCN(c3ccc(Nc4nc(-c5ccccc5)cs4)cc3)CC2)cc1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20040142850A1,CCOC(=O)Nc1c([N+](=O)[O-])cc(Br)cc1C(F)(F)F.FC(F)(F)c1cccc(CBr)c1>>CCOC(=O)N(Cc1cccc(C(F)(F)F)c1)c1c([N+](=O)[O-])cc(Br)cc1C(F)(F)F,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090131457A1,Cn1nc(Br)c2cnc(S(C)(=O)=O)nc21.N>>Cn1nc(Br)c2c(N)ncnc21,,C1COCCO1,,,,val
US04350695,O=[N+]([O-])O.Oc1nc(Cl)nc2ccccc12>>O=[N+]([O-])c1ccc2nc(Cl)nc(O)c2c1,,O=S(=O)(O)O,,,,val
US20140194431A1,CC(C)(C)OC(=O)c1nc(CC2(c3ccc(Cl)cc3)CCCC2)nc(O)c1OCc1ccccc1>>O=C(O)c1nc(CC2(c3ccc(Cl)cc3)CCCC2)nc(O)c1OCc1ccccc1,,C1CCOC1,O,[Li]O,,val
US20080103133A1,CC(C)(C)OC(=O)NC1CN(C(=O)OCC(F)(F)F)c2ccccc2N(CCOCc2ccccc2)C1=O.Cl>>Cl.N[C@H]1CN(C(=O)OCC(F)(F)F)c2ccccc2N(CCOCc2ccccc2)C1=O,,C1COCCO1,,,,val
US20040152702A1,CCO.COc1ccc(-c2ccc(F)cc2)c2oc(NC(=O)c3ccnc(CCl)c3)nc12>>COCc1cc(C(=O)Nc2nc3c(OC)ccc(-c4ccc(F)cc4)c3o2)ccn1,,C1COCCO1,CN(C)C=O,[H-].[Na+],,val
US20140213580A1,N#Cc1ccc(C2CC2)nc1O.O=[N+]([O-])O>>N#Cc1cc([N+](=O)[O-])c(C2CC2)nc1O,,CC(=O)OC(C)=O,,,,val
US20100016365A1,CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O,,CCO,,O,,val
US20070082912A1,CC(=O)CCC(=O)c1cc(Cl)ccc1OCc1cccc(F)c1F.COC(=O)c1cc(N)cc(O)c1>>COC(=O)c1cc(O)cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2cccc(F)c2F)c1,,CC#N,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,,val
US05585394,CCOc1ccc2c(c1)n(C1CCCCC1)c(=O)n2S(=O)(=O)c1ccc(C(=O)NC(C)(C)CN(C)C)cc1OC.O=C(O)/C=C/C(=O)O>>CCOc1ccc2c(c1)n(C1CCCCC1)c(=O)n2S(=O)(=O)c1ccc(C(=O)NC(C)(C)CN(C)C)cc1OC.O=C(O)/C=C/C(=O)O,,CC(C)=O,,,,val
US20030003245A1,C[Si](C)(C)C[Si](C)(C)CCCCCCOc1cnc(-c2ccc(O)cc2)nc1.Cc1ccc(S(=O)(=O)OCCCC[Si](C)(C)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc1>>C[Si](C)(C)C[Si](C)(C)CCCCCCOc1cnc(-c2ccc(OCCCC[Si](C)(C)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc2)nc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130158042A1,CCOC(=O)CNCc1ccccc1.COCC(C)=O.C[Si](C)(C)C#N>>CCOC(=O)CN(Cc1ccccc1)C(C)(C#N)COC,,CC(=O)O,,,,val
US20100130496A1,CC1(C)OB(c2cc(F)cc3[nH]ccc23)OC1(C)C.CS(=O)(=O)c1nc(Cl)cc(N2CCOCC2)n1>>CS(=O)(=O)c1nc(-c2cc(F)cc3[nH]ccc23)cc(N2CCOCC2)n1,,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20100144884A1,CC(=O)OCc1ccc(O)c(Cl)c1.COCCOCCl>>COCCOCOc1ccc(COC(C)=O)cc1Cl,,C1CCOC1,CN(C)C=O,O,[H-].[Na+],val
US05116855,CCOC(=O)COc1ccccc1C=CC(C)=[SH]1=CC(=O)NC1=S>>CC(C=Cc1ccccc1OCC(=O)O)=[SH]1=CC(=O)NC1=S,,O,,Cl,[Na+].[OH-],val
US05183820,Cc1c(CN2CCc3c(c4cccc(F)c4n3C)C2=O)ncn1S(=O)(=O)N(C)C>>Cc1[nH]cnc1CN1CCc2c(c3cccc(F)c3n2C)C1=O,,CCO,,Cl,[Na+].[OH-],val
US20050250914A1,CCC(CO)(CO)CO.O=C(O)CCCCC(=O)O>>CCC(CO)(CO)CO.O=C(O)CCCCC(=O)O,,O,,Cc1ccccc1,,val
US20090186909A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCCC1(O)CCC1>>Cc1ccc(S(=O)(=O)OCCC2(O)CCC2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20150259317A1,CC(=O)OC(C)OC(=O)CCC(=O)OCc1ccccc1.CCOC(C)=O>>CC(=O)OC(C)OC(=O)CCC(=O)O.CCCC(C)C,[Pd],CCOC(C)=O,,,,val
US20080085890A1,CO/C=C1/C(=O)NC(=O)c2ccc(Br)cc21.COc1ccc(C(C)N)cc1O>>COc1ccc(C(C)N/C=C2\C(=O)NC(=O)c3ccc(Br)cc32)cc1O,,CN(C)C=O,,CCN(CC)CC,Cl,val
US04153794,CN1CCN(Cc2ccccc2[N+](=O)[O-])CC1>>CN1CCN(Cc2ccccc2N)CC1,[Ni],CCO,,NN,O,val
US20160200704A1,Cc1nc(N)ccc1CNC(=O)OC(C)(C)C.O=C1CCC(=O)N1Br>>Cc1nc(N)c(Br)cc1CNC(=O)OC(C)(C)C,,ClCCl,,,,val
US05002853,C=Cc1ccc(S(=O)(=O)Cl)cc1.CC(C)=O.O=C1CC(c2ccccc2)C(=O)N1O>>C=Cc1ccc(S(=O)(=O)[O-])cc1.O=C1CC(c2ccccc2)C(=O)N1O,,CC(C)=O,,,,val
US05760032,CCOC(=O)CCC1(C(=O)OCC)N=C(c2ccccc2Cl)c2cc(CC)sc2-n2c(C)nnc21>>CCc1cc2c(s1)-n1c(C)nnc1C(CCC(=O)O)N=C2c1ccccc1Cl,,CCO,,Cl,[Na+].[OH-],val
US05276039,C=C(CBr)c1ccccc1.O=[N+]([O-])c1ccc(Cl)cc1O>>O=[N+]([O-])c1ccc(Cl)cc1OCC=Cc1ccccc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090111798A1,COC(=O)[C@@H]1CCCC[C@@H]1N.O=Cc1ccc(F)cc1>>COC(=O)[C@@H]1CCCC[C@@H]1NCc1ccc(F)cc1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US06576656B1,CCN(CC)CCN1C(=O)C(=O)c2c(Br)cccc21.c1ccc2scnc2c1>>CCN(CC)CCN1C(=O)C(O)(c2nc3ccccc3s2)c2c(Br)cccc21,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20030171418A1,C[C@H](Cn1ncc2ccc(OCC(=O)OC(C)(C)C)c(CCl)c21)O[Si](C)(C)C(C)(C)C>>C[C@H](Cn1ncc2ccc3c(c21)CC(C(=O)OC(C)(C)C)O3)O[Si](C)(C)C(C)(C)C,,CN1CCCC1=O,,[H-].[Na+],,val
US06235900B1,Cc1cc[nH]n1.O=C(c1ccc(F)cc1F)N1Cc2cccnc2Nc2ccccc21>>Cc1ccn(-c2ccc(C(=O)N3Cc4cccnc4Nc4ccccc43)c(F)c2)n1,,CCCCCC,,[H-].[Na+],,val
US20130079342A1,CN.O=C(O)c1cc(Cl)cc(N2CCOCC2)n1>>CNC(=O)c1cc(Cl)cc(N2CCOCC2)n1,CN(C)c1ccncc1,CN(C)C=O,,ClCCCl,,val
US20060052374A1,N#Cc1cccnc1Oc1ccccc1>>NCc1cccnc1Oc1ccccc1,[Ni],,,,,val
US20040259957A1,CCOc1ccc(C=O)cc1O.COc1cc(C(C)=O)cc(OC)c1OC>>CCOc1ccc(/C=C/C(=O)c2cc(OC)c(OC)c(OC)c2)cc1O,,CCOC(C)=O,CO,[Na+].[OH-],,val
US20100216746A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1nc(Cl)c(C(=O)O)[nH]1.N#Cc1cc(Cl)cc(Oc2c(Br)ccc(CN)c2F)c1.O=C(O)C(F)(F)F>>N#Cc1cc(Cl)cc(Oc2c(Br)ccc(CNC(=O)c3[nH]c(N)nc3Cl)c2F)c1.O=C(O)C(F)(F)F,,CN(C)C=O,ClCCl,ClCCCl,On1nnc2ccccc21,val
US20110105459A1,COC(=O)C(C)(C)c1ccc(OC2CN(C(=O)N3CCCN(C4CCC4)CC3)C2)cn1>>CC(C)(CO)c1ccc(OC2CN(C(=O)N3CCCN(C4CCC4)CC3)C2)cn1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090318475A1,CCOC(=O)CCCCCOc1ncnc2oc(-c3ccccc3)c(-c3ccc(OC)cc3)c12>>COc1ccc(-c2c(-c3ccccc3)oc3ncnc(OCCCCCC(=O)O)c23)cc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20050267105A1,CCOC(=O)c1nc2n(c(=O)c1OCc1ccccc1)CCOC2CCSC>>CSCCC1OCCn2c1nc(C(=O)O)c(OCc1ccccc1)c2=O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20050288289A1,CCOC(=O)c1cn2ncnc(Cl)c2c1C.O=[N+]([O-])c1ccc(O)c(F)c1>>CCOC(=O)c1cn2ncnc(Oc3ccc([N+](=O)[O-])cc3F)c2c1C,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20080045534A1,COc1cccc(C)c1N.O=C(Cl)CCC1CCCC1>>COc1cccc(C)c1NC(=O)CC1CCCC1,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20140113901A1,CC(C)(C)OC(=O)NC1(c2ccc(C(=O)C(Br)c3ccccc3)cc2)CCC1.COc1ccc(N)nn1>>COc1ccc2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)n2n1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20130116245A1,C=O.O=S(=O)(c1ccccc1)N1CC2COCC(C1)N2>>CN1C2COCC1CN(S(=O)(=O)c1ccccc1)C2,CC(=O)O,CC#N,,[BH3-]C#N.[Na+],,val
US20120270838A1,BrCc1ccccc1.O=C(O)C1CCC(CO)CC1>>O=C(OCc1ccccc1)C1CCC(CO)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110263557A1,CCc1cnc(N2CCC(Oc3ccc(CN4CCN(C#N)CC4)cc3Cl)CC2)nc1.[N-]=[N+]=[N-]>>CCc1cnc(N2CCC(Oc3ccc(CN4CCN(c5nn[nH]n5)CC4)cc3Cl)CC2)nc1,,CN(C)C=O,O,[Cl-].[NH4+],,val
US20090270430A1,CSc1nc(C)cc(NC(C)C)n1.ClI>>CSc1nc(C)c(I)c(NC(C)C)n1,,CO,,,,val
US04322370,CC1(C)CC(c2ccc(Cl)cc2)c2ccc(O)cc2C1=O.ClCC1CO1>>CC1(C)CC(c2ccc(Cl)cc2)c2ccc(OCC3CO3)cc2C1=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130040930A1,COC(=O)c1ccc(CBr)cc1.C[C@@H]1CCS(=O)(=O)N1>>COC(=O)c1ccc(CN2[C@H](C)CCS2(=O)=O)cc1,,C1CCOC1,CN(C)C=O,Cl,[H-].[Na+],val
US20080113980A1,Cc1cc2cc(Cl)ccc2[nH]1>>CC1Cc2cc(Cl)ccc2N1,,CC(=O)O,CCOC(C)=O,[BH3-]C#N.[Na+],,val
US20020198197A1,C=CCBr.CCOC(C)=O.COC(=O)c1coc(-c2cccc(C(=O)Cl)c2)n1.O=C(O)c1cccc(C(=O)O)c1>>C=CCOC(=O)c1cccc(C(=O)O)c1.COC(=O)c1coc(-c2cccc(C(=O)CC(=O)O)c2)n1,,CCOC(C)=O,CS(C)=O,CN(C)C(=N)N(C)C,,val
US06218431B1,CC(C)(C)[Si](C)(C)Cl.CCCCCc1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccc(F)cc1>>CCCCCc1c(C(C)C)nc(C(C)C)c(CO[Si](C)(C)C(C)(C)C)c1-c1ccc(F)cc1,,ClCCl,,c1c[nH]cn1,,val
US04956366,O=S(Cl)Cl.OCc1cc(N2CCOCC2)ncn1>>Cl.ClCc1cc(N2CCOCC2)ncn1,,ClCCl,,,,val
US20100022484A1,CC(N)=CC(=O)CCC1CCC1.COC(=O)C(=Cc1cccc2c(=O)cc(C)oc12)C(C)=O>>COC(=O)C1=C(C)NC(C)=C(C(=O)CCC2CCC2)C1c1cccc2c(=O)cc(C)oc12,,CCO,,,,val
US20040127538A1,Nc1ccc2c(c(-c3cccc(F)c3)nn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1Br.O=C(Cl)C1CC1>>O=C(Nc1ccc2c(c(-c3cccc(F)c3)nn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1Br)C1CC1,,C1CCOC1,,CCN(CC)CC,O,val
US20120309739A1,CNc1nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c(=O)n1CC(F)(F)F>>CNc1nc2oc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)c2c(=O)n1CC(F)(F)F,,ClCCl,,,,val
US20150152048A1,CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)N1CCNCC1.CC(C)(C)OC(=O)c1ccc(NC(=O)[C@@H]2C[C@H](N3CCN(S(C)(=O)=O)CC3)CN2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)N1CCN(C(=O)N2C[C@@H](N3CCN(S(C)(=O)=O)CC3)C[C@H]2C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US05721247,CN(CCc1ccc(NC(=S)NC(=O)c2ccccc2)cc1)Cc1ccccc1>>CN(CCc1ccc(NC(N)=S)cc1)Cc1ccccc1,,O,,[Na+].[OH-],,val
US20110201592A1,CC(C)(C)OC(=O)N1CC[C@H](N)C1.Clc1ccnc(Cl)n1>>CC(C)(C)OC(=O)N1CC[C@H](Nc2ccnc(Cl)n2)C1,,CC(=O)N(C)C,,CCN(CC)CC,O,val
US05036053,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C(N)C(=O)OCc1ccccc1>>COC(=O)C(NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1,,CCOCC,,,,val
US20020103204A1,C1COCCN1.CC(C)(C)OC(=O)N1CCN(c2nccnc2OCCOc2cccc(C=O)c2)CC1>>CC(C)(C)OC(=O)N1CCN(c2nccnc2OCCOc2cccc(CN3CCOCC3)c2)CC1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05908858,CSc1ccc(-c2cc(C)cn2-c2ccc(S(N)(=O)=O)cc2)cc1.O=C(OO)c1cccc(Cl)c1>>Cc1cc(-c2ccc(S(C)=O)cc2)n(-c2ccc(S(N)(=O)=O)cc2)c1,,ClC(Cl)Cl,,,,val
US20030220364A1,COC(=O)Cl.Cc1cccc(O)c1CNc1cccn2c(C)c(C)nc12.ClCCl>>COC(=O)Oc1cccc(C)c1CNc1cccn2c(C)c(C)nc12.Cl,,CC(C)=O,,[K+].[OH-],,val
US20150080412A1,BrCC1CC1.CC(C)(C)c1ccc(Cn2nc(CCCc3ccc(Br)cc3)[nH]c2=O)cc1>>CC(C)(C)c1ccc(Cn2nc(CCCc3ccc(Br)cc3)n(CC3CC3)c2=O)cc1,,CCOCC,CN(C)C=O,[H-].[Na+],,val
US20070299086A1,CC(C)(C)OC(=O)CNC(=O)c1ncc(O)cc1O>>O=C(O)CNC(=O)c1ncc(O)cc1O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100048625A1,CC(C)c1noc(N2CCC(CCCO)CC2)n1.COC(=O)c1ccc(O)cn1>>COC(=O)c1ccc(OCCCC2CCN(c3nc(C(C)C)no3)CC2)cn1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20010051614A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc(N)c(OC)n1>>COc1ccc(NC(=O)OC(C)(C)C)c(OC)n1,,O,,,,val
US20110021522A1,CCOc1ccc(B(O)O)cc1.Nc1cccc(Br)c1>>CCOc1ccc(-c2cccc(N)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20140295181A1,CO[Si](CCCOCC1CO1)(OC)OC>>O[Si](O)(O)CCCOCC1CO1,,O,,,,val
US20040122001A1,C=CCBr.COC(=O)c1ccc2c(c1)CCCN2>>C=CCN1CCCc2cc(C(=O)OC)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20090069408A1,COC(=O)c1cc(F)cc2c1-c1c(C(=O)OC)cc(F)cc1-2>>OCc1cc(F)cc2c1-c1c(CO)cc(F)cc1-2,,C1CCOC1,,CO,[BH4-].[Na+],val
US07271262B2,CC(C)(C)OC(=O)N1CCC(n2cc(C(=O)c3cccc(NC(=O)Nc4cc(Cl)cc(Cl)c4)c3)c3c(N)ncnc32)CC1>>Nc1ncnc2c1c(C(=O)c1cccc(NC(=O)Nc3cc(Cl)cc(Cl)c3)c1)cn2C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05623081,CC(C)(C)[Si](OC[C@H]1O[C@H](CN=[N+]=[N-])C[C@H]1O)(c1ccccc1)c1ccccc1>>CC(C)(C)[Si](OC[C@H]1O[C@H](CN)C[C@@H]1O)(c1ccccc1)c1ccccc1,[Pd],C1CCOC1,,[H][H],,val
US20110245303A1,COC(=O)Cc1ccc(OC)c(B2OC(C)(C)C(C)(C)O2)c1.O=Cc1cc(C(F)(F)F)ccc1Br>>COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2C=O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,ClCCl,O=C([O-])[O-].[K+].[K+],val
US05350751,CCCCc1nc(Cl)c(CO)[nH]1>>CCCCc1nc(Cl)c(C=O)[nH]1,,CC(=O)O,O,[K+].[OH-],,val
US04971980,CN(C)CCCC(=O)O.Nc1ccccc1N>>CN(C)CCCc1nc2ccccc2[nH]1,,O,,Cl,,val
US05254573,CC(C)(C)OC(=O)CC(N)c1cncnc1.CCO.Cl>>CCOC(=O)CC(N)c1cncnc1.Cl,,C1COCCO1,CCO,O=C(O)C(F)(F)F,,val
US20130184265A1,Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1.O=C(Cl)OCCl>>Cc1cc2c(s1)=Nc1ccccc1N(C(=O)OCCl)C=2N1CCN(C)CC1,,ClCCl,,CCN(CC)CC,,val
US20140364432A1,C[C@@H]1CCCN(C(=O)OCc2ccccc2)[C@@H]1CN1C(=O)c2ccccc2C1=O>>C[C@@H]1CCCN[C@@H]1CN1C(=O)c2ccccc2C1=O,[Pd],CC(=O)O,,,,val
US20140194386A1,CI.COC(=O)c1ccc2c(c1)NC(=S)NC2>>COC(=O)c1ccc2c(c1)N=C(SC)NC2,,CCO,,,,val
US20090044345A1,CN.ClCc1ccccn1>>CNCc1ccccn1,,CC(C)O,,Cl,,val
US20150225412A1,C=CC(=O)Cl.O=C(Nc1nc2ccccc2n1C1CCNCC1)c1cccnc1>>C=CC(=O)N1CCC(n2c(NC(=O)c3cccnc3)nc3ccccc32)CC1,,C1CCOC1,,Cl,,val
US20020061872A1,OCCc1c(Cl)ccc(NCC(F)(F)c2ccccc2)c1F>>O=CCc1c(Cl)ccc(NCC(F)(F)c2ccccc2)c1F,,ClCCl,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20100190778A1,CC1=NNS(=O)(=O)c2c1cc(C)c(Cl)c2Cl>>Cc1cc2c(c(Cl)c1Cl)S(=O)(=O)NNC2C,O=[Pt]=O,,,,,val
US20110178132A1,NC(=NO)c1cc(OCc2ccccc2C(F)(F)F)ccn1.O=C(n1ccnc1)n1ccnc1>>O=c1nc(-c2cc(OCc3ccccc3C(F)(F)F)ccn2)[nH]o1,,C1CCOC1,O,C1CCC2=NCCCN2CC1,Cl,val
US20140364432A1,CI.Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ccc(C(F)(F)F)cn2)n1>>Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CN(C)c2ccc(C(F)(F)F)cn2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20070197512A1,C=CC(=O)OC.CC(C)c1cccc2c1OC(C)(C)C(=O)N2>>COC(=O)CCN1C(=O)C(C)(C)Oc2c(C(C)C)cccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070249680A1,N#CC1(c2ccc([N+](=O)[O-])cc2)CCOCC1>>N#CC1(c2ccc(N)cc2)CCOCC1,[Pd],CO,,,,val
US20160264582A1,CI.O=C1[C@H]2CN(C(=O)n3ccnc3)C[C@H]2CN1c1cccc2c1cnn2-c1ccccc1F>>C[n+]1ccn(C(=O)N2CC3CN(c4cccc5c4cnn5-c4ccccc4F)C(=O)C3C2)c1.[I-],,CC#N,,,,val
US20110003807A1,CCOC(=O)C(Br)C(=O)c1ccccc1.NC(=S)c1ccncc1>>CCOC(=O)c1sc(-c2ccncc2)nc1-c1ccccc1,,CCO,,,,val
US20040097732A1,CCCCC(CC(=O)OCC)C[N+](=O)[O-]>>CCCCC1CNC(=O)C1,[Ni],CO,,[H][H],,val
US20090264474A1,Cc1c(N(Cc2ccc(F)c(F)c2)C(=O)OC(C)(C)C)sc2ccccc12>>Cc1c(NCc2ccc(F)c(F)c2)sc2ccccc12,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100298324A1,COC(=O)c1ccc(C(=O)NCc2ccc(Cl)cc2)cc1N=C=S.Nc1cccnc1>>O=C(NCc1ccc(Cl)cc1)c1ccc2c(=O)n(-c3cccnc3)c(=S)[nH]c2c1,,C1CCOC1,CO,,,val
US20050182059A1,Nc1ccc(Cl)nn1.OCC1CC1>>Nc1ccc(OCC2CC2)nn1,,O,,[Na],,val
US20100056511A1,CC(C)c1cc([N+](=O)[O-])ccc1C(=O)OCCBr.CC(C)c1ncc[nH]1>>CC(C)c1cc([N+](=O)[O-])ccc1C(=O)OCCn1ccnc1C(C)C,,CN(C)C=O,O,CCN(CC)CC,,val
US20110166132A1,Cc1cc(-c2ccc(NC(=O)C(C)c3cc(Cl)ccn3)cc2)ccn1.OB(O)c1ccc(N2CCOCC2)cc1>>Cc1cc(-c2ccc(NC(=O)C(C)c3cc(-c4ccc(N5CCOCC5)cc4)ccn3)cc2)ccn1,,C1COCCO1,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20050277674A1,CN(C)C1(c2ccccc2)CCC(=CC(=O)N2CCC(c3c[nH]c4ccccc34)CC2)CC1.C[Si](C)(C)Cl>>CN(C)C1(c2ccccc2)CCC(=CC(=O)N2CCC(c3c[nH]c4ccccc34)CC2)CC1.Cl,,CCC(C)=O,,,,val
US20110124665A1,COC(=O)COc1cccc(Nc2ncnc3oc(-c4ccccc4)c(-c4ccc(OC)cc4)c23)c1>>COc1ccc(-c2c(-c3ccccc3)oc3ncnc(Nc4cccc(OCC(=O)O)c4)c23)cc1,,C1CCOC1,,[Na+].[OH-],,val
US20130217709A1,C=O.C[Si](C)(C)CCOC(=O)NC1CNCC1c1cccc(F)c1>>CN1CC(NC(=O)OCC[Si](C)(C)C)C(c2cccc(F)c2)C1,,CCO,,O=CO,,val
US20160229843A1,COc1cncc(-c2ccc(N)c(O)c2)c1.Cc1cc(C(F)(F)F)[nH]n1>>COc1cncc(-c2ccc3nc(-c4cc(C)n[nH]4)oc3c2)c1,,CO,,O,[Na+].[OH-],val
US20120134934A1,CC(C)C(NC(=O)c1ccccc1)C(=O)O.O[C@H]1CN2CCC1CC2>>CC(C)C(NC(=O)c1ccccc1)C(=O)O[C@H]1CN2CCC1CC2,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20090069336A1,Br[Mg]CCC1OCCCO1.Nc1nc(-c2ccc(Cl)cc2Cl)c2cc(C=O)sc2n1>>Nc1nc(-c2ccc(Cl)cc2Cl)c2cc(C(O)CCC3OCCCO3)sc2n1,,C1COCCO1,,[Cl-].[NH4+],,val
US20140135306A1,COc1cc2c(cc1OC(C)C)[C@H](c1ccc(Cl)cc1)NC(=O)C2.COc1cccc(C(C)(O)c2ccc(I)cc2)c1>>COc1cccc(C(C)(O)c2ccc(N3C(=O)Cc4cc(OC)c(OC(C)C)cc4[C@@H]3c3ccc(Cl)cc3)cc2)c1,[Cu]I,C1COCCO1,CCOC(C)=O,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20090143353A1,CN(C)[C@H]1CCNC1.Cc1c(-c2ccccc2)c(F)c2oc(COCc3ccccc3)nc2c1C#N>>Cc1c(-c2ccccc2)c(N2CC[C@H](N(C)C)C2)c2oc(COCc3ccccc3)nc2c1C#N,,CS(C)=O,O,CCN(CC)CC,CCOC(C)=O,val
US20150315172A1,Cc1cc(C#N)ccc1N.Cn1cc(C(=O)N2CCC(c3ccc(F)cc3)CC2)c(Cl)c(Cl)c1=O>>Cc1cc(C#N)ccc1Nc1c(C(=O)N2CCC(c3ccc(F)cc3)CC2)cn(C)c(=O)c1Cl,,C1CCOC1,,O,[H-].[Na+],val
US20100292212A1,COC/C=C/c1ccc(N2CCC3(CCN(S(=O)(=O)c4ccccc4OC(F)(F)F)CC3)C2=O)cc1>>COCCCc1ccc(N2CCC3(CCN(S(=O)(=O)c4ccccc4OC(F)(F)F)CC3)C2=O)cc1,[Pd],CO,,,,val
US20070197604A1,C=Cc1nc(-c2ccc(Br)cc2)oc1C.O.O=C1CCC(=O)N1Br>>Cc1oc(-c2ccc(Br)cc2)nc1C(O)CBr,,CS(C)=O,,CCOC(C)=O,,val
US05444074,COS(=O)(=O)OC.FC(F)(F)c1cc(CO[C@@H]2CCCN(Cc3nnn[nH]3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1>>Cn1nnc(CN2CCC[C@@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)n1,,O,,[Na+].[OH-],,val
US20090221583A1,O=C(NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1)c1cc(-c2cccc(OCc3ccccc3)c2)[nH]n1>>O=C(NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1)c1cc(-c2cccc(O)c2)[nH]n1,[Pd],CO,ClCCl,,,val
US20030203946A1,CC(=O)OC(C)=O.O=C(Nc1cc(Cl)cc(Cl)c1)N(Cc1ccc(C(O)Cc2nn[nH]n2)cc1)c1ccc(C2=CCCCC2)cc1>>CC(=O)OC(Cc1nn[nH]n1)c1ccc(C(NC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C3=CCCCC3)cc2)cc1,,ClCCl,,CCO,,val
US20070238737A1,COc1ccc(N2C[C@H](C)N(C(=O)OC(C)(C)C)[C@H](C)C2)nc1NS(=O)(=O)c1ccc(Br)cc1Cl.Cc1csc(B(O)O)c1>>COc1ccc(N2C[C@H](C)N(C(=O)OC(C)(C)C)[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl,,CCOC(C)=O,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],val
US20140045862A1,CC(C)(C)OC(=O)N(c1cscn1)S(=O)(=O)c1cc(Cl)c(O[C@H]2CCCC[C@H]2n2ccnc2)cc1F>>O=S(=O)(Nc1cscn1)c1cc(Cl)c(O[C@H]2CCCC[C@@H]2n2ccnc2)cc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US05753665,CCc1ccnc2ncnn12.O=C1CCC(=O)N1Br>>CC(Br)c1ccnc2ncnn12,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US04908366,CCN1CCNCC1.N#Cc1c(Cl)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12>>CCN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2C#N)CC1,,C1COCCO1,,,,val
US20120094996A1,COc1ccc(-c2c(C)nc3sc(-c4ccc(OC)c(OC)c4)nn23)cn1>>COc1ccc(-c2nn3c(-c4ccc(O)nc4)c(C)nc3s2)cc1OC,,Cl,,O=C([O-])O.[Na+],,val
US20060223849A1,CO.Nc1c([N+](=O)[O-])ccc(F)c1C(=O)O>>COc1ccc([N+](=O)[O-])c(N)c1C(=O)O,,CO,,C[O-].[Na+],,val
US20100016279A1,OC1CCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1.Oc1ccc(OCc2ccccc2)cc1>>FC(F)(F)c1nnc2ccc(N3CCC(Oc4ccc(OCc5ccccc5)cc4)CC3)nn12,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050026963A1,NNc1cccc(Br)c1.O=CC(C=O)c1ccccn1>>Brc1cccc(-n2cc(-c3ccccn3)cn2)c1,,CCO,,Cl,,val
US20110003807A1,CCOc1cccc(F)c1B(O)O.COC(=O)c1sc(-c2c(C)nn3ccccc23)nc1OS(=O)(=O)C(F)(F)F>>CCOc1cccc(F)c1-c1nc(-c2c(C)nn3ccccc23)sc1C(=O)OC,,COCCOC,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20050215577A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNC(=O)C(F)(C1CCc2c([nH]c3ccc(Cl)cc23)C1)S(=O)(=O)c1ccccc1>>CNC(=O)C(F)(C1CCc2c(n(C(=O)OC(C)(C)C)c3ccc(Cl)cc23)C1)S(=O)(=O)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20070249637A1,COC(=O)[C@@]12C[C@H]1C=CCCCCC[C@H](N)C(=O)N1C[C@H](Oc3nc(-c4cc(C)nn4C)nc4ccsc34)C[C@H]1C(=O)N2.O=C(Oc1ccc([N+](=O)[O-])cc1)OC1CCC1>>COC(=O)[C@@]12C[C@H]1C=CCCCCC[C@H](NC(=O)OC1CCC1)C(=O)N1C[C@H](Oc3nc(-c4cc(C)nn4C)nc4ccsc34)C[C@H]1C(=O)N2,,CC(=O)N(C)C,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20030171411A1,CC(C)SC(C(=O)O)c1ccc(Cl)c(Cl)c1.Nc1ccccn1>>CC(C)SC(C(=O)Nc1ccccn1)c1ccc(Cl)c(Cl)c1,,C1CCOC1,,,,val
US20120115898A1,C[Si](C)(C)CCOCn1nc(NC2CCN(S(C)(=O)=O)CC2)c2nc(-c3c(F)cccc3F)c3ccccc3c21>>CS(=O)(=O)N1CCC(Nc2n[nH]c3c2nc(-c2c(F)cccc2F)c2ccccc23)CC1,,ClCCl,O,O=C(O)C(F)(F)F,,val
US20060166983A1,CCOC(=O)C(=O)c1cn(CC)c2cc(OCc3ccccc3)ccc12>>CCOC(=O)Cc1cn(CC)c2cc(O)ccc12,,C1COCCO1,,,,val
US20050080262A1,COc1cc(C(=O)O)c([N+](=O)[O-])cc1OCCCl>>COc1cc(C(=O)O)c(N)cc1OCCCl,[Pd],CO,,[H][H],,val
US20090281087A1,CN1CCN(CCOC(=O)Oc2ccc([N+](=O)[O-])cc2)CC1.Cc1ccc(C)c(N2CCNCC2)c1>>Cc1ccc(C)c(N2CCN(C(=O)OCCN3CCN(C)CC3)CC2)c1.N,,CN(C)C=O,,CCN(CC)CC,,val
US04304791,COS(=O)(=O)OC.O=[N+]([O-])c1cc([N+](=O)[O-])c(Nc2ccc(OC(F)(F)C(F)F)cc2)c(C(F)(F)F)c1>>CN(c1ccc(OC(F)(F)C(F)F)cc1)c1c([N+](=O)[O-])cc([N+](=O)[O-])cc1C(F)(F)F,,CC(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20140163025A1,CC1(C)CO1.COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccc(C#N)c(O)c5)ccc(F)c43)ccc21>>COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccc(C#N)c(OCC(C)(C)O)c5)ccc(F)c43)ccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080318957A1,CC(C)(C)OC(=O)N[C@@H](CCCN1CCC(NC(=O)OCc2ccccc2)C1)C(=O)N[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)Nc1cnc2ccccc2c1>>CC(C)(C)OC(=O)N[C@@H](CCCN1CCC(N)C1)C(=O)N[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)Nc1cnc2ccccc2c1,[Pd],CO,,,,val
US20030232809A1,Cc1cc2c(-c3cccc([N+](=O)[O-])c3)c(CC(=O)Nc3ccc(Cl)cc3C(F)(F)F)c(=O)oc2cc1Cl>>Cc1cc2c(-c3cccc(N)c3)c(CC(=O)Nc3ccc(Cl)cc3C(F)(F)F)c(=O)oc2cc1Cl,[Ni],C1CCOC1,CCO,,,val
US04063019,CCOC(=O)C(N=C=O)c1cccs1.NN1CC(=O)NC1=O>>CCOC(=O)C(NC(=O)NN1CC(=O)NC1=O)c1cccs1,,C1COCCO1,,,,val
US04985422,CCOC(=O)NCCc1cc2ccccc2s1>>O=C1NCCc2sc3ccccc3c21,,O,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20090163706A1,C=C[C@@H]1C[C@]1(N)C(=O)OCC.CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)O>>C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C)C(=O)OCC,,C1CCOC1,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20060148858A1,CCOC(=O)CP(=O)(OCC)OCC.COc1cccc(OCc2ccccc2)c1C=O>>CCOC(=O)/C=C/c1c(OC)cccc1OCc1ccccc1,,O,,CN(C)C=O,[H-].[Na+],val
US20060052392A1,CCOC(=O)c1cc2c(cc1C(=O)OCC)CCC2>>O=C(O)c1cc2c(cc1C(=O)O)CCC2,,CC(=O)O,,Cl,,val
US20040204447A1,COC(=O)c1cccc(Cl)c1C.O=C1CCC(=O)N1Br>>COC(=O)c1cccc(Cl)c1CBr,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20100310512A1,CN(Cc1cc(-c2cnc(C3CCCN3C(=O)OC(C)(C)C)[nH]2)ccc1Br)C(=O)OC(C)(C)C.COC(=O)c1cc(-c2cnc(C3CCCN3C(=O)OC(C)(C)C)[nH]2)ccc1B1OC(C)(C)C(C)(C)O1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCCC1c1ncc(-c2ccc(-c3ccc(-c4cnc(C5CCCN5C(=O)OC(C)(C)C)[nH]4)cc3)cc2)[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,O=C([O-])O.[Na+],,val
US20080275043A1,NN1CCCCC1.O=C(Cl)CCCCl>>O=C(CCCCl)NN1CCCCC1,,ClCCl,,O=C([O-])O.[Na+],,val
US20090176794A1,NCc1cccnc1.O=C(Nn1ccc2ccccc21)n1ccnc1>>O=C(NCc1cccnc1)Nn1ccc2ccccc21,,ClCCl,,CCN(CC)CC,,val
US20140045689A1,CN1C(=O)C(Cl)=C(N=P(c2ccccc2)(c2ccccc2)c2ccccc2)C1=O>>CN1C(=O)C(N)=C(Cl)C1=O,,C1CCOC1,O,,,val
US20050137240A1,CC(C)(C)OC(=O)NCC1CCC(N)CC1.O=C(N=C=S)c1ccccc1>>CC(C)(C)OC(=O)NCC1CCC(NC(=S)NC(=O)c2ccccc2)CC1,,C1CCOC1,,,,val
US20070093484A1,CCOC(=O)c1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)nc1CO>>CCOC(=O)c1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)nc1C=O,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20100063049A1,Cc1ncc(-c2ccnc(N[C@@H]3CC[C@@H](NC(=O)CC4CCN(C(=O)OC(C)(C)C)CC4)CC3)n2)n1C(C)C>>Cc1ncc(-c2ccnc(N[C@@H]3CC[C@@H](NC(=O)CC4CCNCC4)CC3)n2)n1C(C)C,,ClCCl,,CO,O=C(O)C(F)(F)F,val
US20130158001A1,CCOC(=O)C=CC1(c2cccc(C(F)(F)F)c2)CCOCC1>>CCOC(=O)CCC1(c2cccc(C(F)(F)F)c2)CCOCC1,O=[Pt]=O,CCO,,,,val
US20110034689A1,O=[N+]([O-])c1ccnc(Cl)c1.OCc1ccccc1>>Clc1cc(OCc2ccccc2)ccn1,,C1CCOC1,O,[H-].[Na+],,val
US20070270434A1,BrP(Br)Br.OCc1ccc(OC(F)(F)F)cc1>>FC(F)(F)Oc1ccc(CBr)cc1,,ClCCl,,O,,val
US20080167453A1,O=[N+]([O-])c1ccccc1F.OCCc1ccccn1>>O=[N+]([O-])c1ccccc1OCCc1ccccn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04782050,CCOC(C)(OCC)OCC.Nc1ccc2ccccc2c1N>>Cc1nc2ccc3ccccc3c2[nH]1,,CCO,,,,val
US20150038574A1,CC1=C(CC=O)C(C)(C)CCC1.FC(F)(F)c1cccc(Br)c1>>CC1=C(CC(O)c2cccc(C(F)(F)F)c2)C(C)(C)CCC1,II,C1CCOC1,,[Mg],,val
US20090181942A1,COC(=O)C=Cc1ccc(C=C(C)C)n1-c1ccc(Cl)cc1C(O)c1cccc(OC)c1OC>>COC(=O)CC1OC(c2cccc(OC)c2OC)c2cc(Cl)ccc2-n2c(C=C(C)C)ccc21,,ClCCl,,Cl,,val
US20160244429A1,Cc1ccc(S(=O)(=O)OCCCc2c[nH]c3ccc(C#N)cc23)cc1.O=C(O)c1ccc2c(=O)n(-c3ccc(N4CCNCC4)cc3)ccc2n1>>N#Cc1ccc2[nH]cc(CCCN3CCN(c4ccc(-n5ccc6nc(C(=O)O)ccc6c5=O)cc4)CC3)c2c1,,CC#N,,[I-].[K+],,val
US20140249129A1,N.N#Cc1ccc(C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)CC(C(=O)O)C3)cc1>>N#Cc1ccc(C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)CC(C(N)=O)C3)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20090227622A1,CC1(C)OBOC1(C)C.Nc1ccc(Br)cc1Cl>>CC1(C)OB(c2ccc(N)c(Cl)c2)OC1(C)C,,C1COCCO1,,CCN(CC)CC,,val
US20150210720A1,CC(=O)N1CCN(C(=O)OC(C)(C)C)C[C@H]1CO.CI>>COC[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(C)=O,,CCOCC,CN(C)C=O,[H-].[Na+],,val
US20050197346A1,Cc1nc2cc(OCC(O)CN3CCNCC3)ccc2s1.ClCCCCOc1ccccc1>>Cc1nc2cc(OC[C@H](O)CN3CCN(CCCCOc4ccccc4)CC3)ccc2s1,,CCO,,CCN(C(C)C)C(C)C,,val
US20160108016A1,CC1=CC(O)=C(C(C)C)CC1.C[C@@H](C(=O)O)c1cc(O)cc(O)c1>>CC1=CC[C@@H]2[C@@H](C1)c1c(O)cc([C@@H](C)C(=O)O)cc1OC2(C)C,,ClC(Cl)Cl,,CCCCCC,,val
US20140200227A1,CC(C)(C)OC(=O)Nc1sc(-c2c(F)cccc2F)nc1C(=O)O.C[C@H]1CN(c2c(N)cnc3c2CCO3)C[C@@H](NC(=O)OC(C)(C)C)[C@]1(C)O>>C[C@H]1CN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnc3c2CCO3)C[C@@H](N)[C@]1(C)O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160068532A1,C=Cc1nc2cn[nH]c2cc1Br.C[Si](C)(C)CCOCCl>>C=Cc1nc2cnn(COCC[Si](C)(C)C)c2cc1Br,,CN(C)C=O,,[H-].[Na+],,val
US06235778B1,Cc1cc(OCC2(CON)CC2)cc(OS(=O)(=O)c2ccccc2S(C)(=O)=O)c1.Cl.N=C(N)c1cc[nH]n1>>Cc1cc(OCC2(CONC(=N)N)CC2)cc(OS(=O)(=O)c2ccccc2S(C)(=O)=O)c1.Cl,,CN(C)C=O,,,,val
US04880806,CCN(CC)S(F)(F)F.CCOC(=O)N1CCN(c2c(F)cc([N+](=O)[O-])c(F)c2CO)CC1>>CCOC(=O)N1CCN(c2c(F)cc([N+](=O)[O-])c(F)c2CF)CC1,,ClCCl,,CCN(CC)CC,,val
US20150274733A1,CC1(C)c2cnc(S(C)(=O)=O)nc2CN1C(=O)OCc1ccccc1>>CC1(C)NCc2nc(S(C)(=O)=O)ncc21,,CC#N,,C[Si](C)(C)I,,val
US20030130270A1,COC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1)c1ccccc1>>COC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)O)c1ccccc1,[Pd],C1CCOC1,CO,,,val
US20080194696A1,O=C1OCC2C[C@@]12c1ccc(Cl)c(Cl)c1>>OCC1C[C@]1(CO)c1ccc(Cl)c(Cl)c1,,C1CCOC1,,ClCCl,,val
US20090264399A1,CCOC(=O)CP(=O)(OCC)OCC.O=C[C@H]1CCC[C@@H](n2c(=O)[nH]c3cnc4[nH]ccc4c32)C1>>O=C(O)/C=C/[C@H]1CCC[C@@H](n2c(=O)[nH]c3cnc4[nH]ccc4c32)C1,,C1CCOC1,,O,[H-].[Na+],val
US04836844,CC1=C(C)C(=O)N(c2nc3ccc(OC(F)(F)F)cc3s2)C1=O>>CC1=C(C)C(O)N(c2nc3ccc(OC(F)(F)F)cc3s2)C1=O,,CO,,CC(=O)O,[BH4-].[Na+],val
US20070179191A1,CCCCc1nc(-c2ccc(C(F)(F)F)cc2)sc1CSc1ccc(C#N)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCc1nc(-c2ccc(C(F)(F)F)cc2)sc1CS(=O)c1ccc(C#N)cc1,,ClCCl,,[Na],,val
US20150152052A1,COC(=O)c1ccc(NC(c2ccc(Br)cc2C)C(C)C)cc1.c1n[nH]c2c1CCCC2>>COC(=O)c1ccc(NC(c2ccc(-n3cc4c(n3)CCCC4)cc2C)C(C)C)cc1,[Cu]I,Cc1ccccc1,O,CN[C@@H]1CCCC[C@H]1NC,O=C([O-])[O-].[K+].[K+],val
US20100311965A1,NC(N)=O.Nc1c(Cl)cccc1C(=O)O>>O=c1[nH]c(=O)c2cccc(Cl)c2[nH]1,,O,,CN1CCCC1=O,,val
US04051129,C1CCC(NC2CCCCC2)CC1.CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1.CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O>>C1CCC([NH2+]C2CCCCC2)CC1.CC(=O)OCC1=C(C(=O)[O-])N2C(=O)[C@@H](N=Cc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)[C@H]2SC1,,CO,,CC(C)O,,val
US05591762,Cc1cc(-c2nc3ccccc3n2C)cc2c1nc(C1CCC1)n2Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>Cc1cc(-c2nc3ccccc3n2C)cc2c1nc(C1CCC1)n2Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04560770,N#Cc1c(F)cccc1F.O=S(=O)(O)O>>NC(=O)c1c(F)cccc1F,,O,,,,val
US20060111375A1,CCCOC(=O)c1ccccc1O.COc1cc2nccc(Cl)c2cc1OC>>CCCOC(=O)c1ccccc1Oc1ccnc2cc(OC)c(OC)cc12,CN(C)c1ccncc1,Clc1ccccc1Cl,,,,val
US20130210796A1,C=O.C[Si](C)(C)N=[N+]=[N-].FC1(F)CCNC1.[C-]#[N+]c1ccc(Cl)cc1>>FC1(F)CCN(Cc2nnnn2-c2ccc(Cl)cc2)C1,,CO,,CCN(CC)CC,Cl,val
US04506001,COc1ccc(OC)c(N)c1N.O=CC=O>>COc1ccc(OC)c2nccnc12,,O,,,,val
US05594081,COC(=O)CCc1ccccc1Br>>O=C(O)CCc1ccccc1Br,,CCO,O,[Na+].[OH-],,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4ncc(F)cc4nn23)CC1.Cl>>Cl.O=c1cc(C2CCNCC2)n2nc3cc(F)cnc3c2[nH]1,,C1COCCO1,CO,,,val
US20130237502A1,CC(C)(C)OC(=O)NCc1ncc(-c2ccc([C@H]3OC(C)(C)N(C(=O)C(F)F)[C@@H]3CF)cc2)cn1.O=C(O)C(F)(F)F>>NCc1ncc(-c2ccc([C@@H](O)[C@@H](CF)NC(=O)C(F)F)cc2)cn1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20100261736A1,CCc1ccc(-c2c(-c3ccccc3)oc3nccc(Cl)c23)cc1.OCCO>>CCc1ccc(-c2c(-c3ccccc3)oc3nccc(OCCO)c23)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20100292319A1,CCCCC(=O)CC(=O)c1ccc(OCc2ccccc2)cc1.NOc1ccc([N+](=O)[O-])cc1>>CCCCc1oc2ccc([N+](=O)[O-])cc2c1C(=O)c1ccc(O)cc1,,Br,CC(=O)O,,,val
US05476661,CCCCCC(=O)Cl.CCCCCCCCCCCCCCCCNCC(O)CO>>CCCCCCCCCCCCCCCCN(CC(O)CO)C(=O)CCCCC,,ClC(Cl)Cl,,,,val
US20140088066A1,BrP(Br)Br.CN(C)C=O.O=C1CCCCC1>>O=CC1=C(Br)CCCC1,,ClC(Cl)Cl,O,O=C([O-])O.[Na+],,val
US20070185133A1,COC(CBr)OC.CSc1ncc(C(N)=S)c(-c2cccs2)n1>>CSc1ncc(-c2nccs2)c(-c2cccs2)n1,Cl,CCO,,,,val
US20130178459A1,COc1ccc(N(C(=O)OC(C)(C)C)C(=O)c2sccc2Br)c(C)c1>>COc1cc(C)c2[nH]c(=O)c3sccc3c2c1,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,,,,,val
US20080312226A1,O=C(Nc1cccnn1)OCC(Cl)(Cl)Cl.c1ccc(-c2csc(N3CCNCC3)n2)cc1>>O=C(Nc1cccnn1)N1CCN(c2nc(-c3ccccc3)cs2)CC1,,O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US06166015,CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.COc1ccc(-c2ccnc(CCC(=O)O)n2)cc1.Cl.ClC(Cl)Cl.NCC1CCN(Cc2cccc(Cl)c2Cl)C1.On1nnc2ccccc21>>COc1ccc(-c2cnc(CCC(=O)NCC3CCN(Cc4cccc(Cl)c4Cl)C3)nc2)cc1.COc1ccc(-c2cnc(CCC(=O)NCC3CCN(Cc4cccc(Cl)c4Cl)C3)nc2)cc1.Cl,,CCOC(C)=O,ClC(Cl)Cl,O,,val
US20140323468A1,CN(Cc1cncc(-c2cnc3c(c2)CCCN3C(=O)OC(C)(C)C)c1)C(=O)C1CCOCC1>>CN(Cc1cncc(-c2cnc3c(c2)CCCN3)c1)C(=O)C1CCOCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130053345A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.Cc1nnc(N2CCC(Oc3nc4ccc(Br)cc4s3)CC2)s1>>Cc1nnc(N2CCC(Oc3nc4ccc(C5=CCN(C(=O)OC(C)(C)C)CC5)cc4s3)CC2)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20090162319A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(Br)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(/C=C/N(C)C)c1[N+](=O)[O-]>>Cc1cc(Br)cc(C)c1Oc1nc(N(C(=O)OC(C)(C)C)c2ccc(C#N)cc2)nc(/C=C/N(C)C)c1[N+](=O)[O-],CN(C)c1ccncc1,ClCCl,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20080132477A1,CC(C)c1cccc(CN2C[C@H]([C@H](Cc3cccc(O)c3)NC(=O)OC(C)(C)C)OC2=O)c1.OCCCBr>>CC(C)c1cccc(CN2C[C@H]([C@H](Cc3cccc(OCCCO)c3)NC(=O)OC(C)(C)C)OC2=O)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20150045368A1,CC1(C)OC(=O)N(C2CCC(Nc3ccncc3[N+](=O)[O-])CC2)[C@H]1c1ccc(F)cc1>>CC1(C)OC(=O)N(C2CCC(Nc3ccncc3N)CC2)[C@H]1c1ccc(F)cc1,[Ni],CCO,,NN,O,val
US20140315889A1,C=C1CCc2c(c3ccccc3n2Cc2ccc(C(=O)OC)cc2)C1=O.COCCN1CCNCC1>>COCCN1CCN(CC2CCc3c(c4ccccc4n3Cc3ccc(C(=O)OC)cc3)C2=O)CC1,,Cc1ccccc1,,,,val
US20100286148A1,O=C(Cl)N1CCCC1.O=c1nc(-c2cc(C(F)(F)F)ccn2)[nH]o1>>O=C(N1CCCC1)n1c(-c2cc(C(F)(F)F)ccn2)noc1=O,,c1ccncc1,,C1CCC2=NCCCN2CC1,,val
US20140148453A1,CC(C)(C)OC(=O)Nc1cccc(O)c1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)Nc1cccc(OCC(F)(F)F)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050277685A1,COC(=O)[C@H](C)O.Cc1cc(O)ccc1Cl>>COC(=O)[C@@H](C)Oc1ccc(Cl)c(C)c1,,ClCCl,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100144707A1,COCCOc1cc2c(Nc3ccc4c(cnn4C(=O)OC(C)(C)C)c3)nc(-c3cccc(NC(=O)c4cccnc4)c3)nc2cc1OC.O=C(O)C(F)(F)F>>COCCOc1cc2c(Nc3ccc4[nH]ncc4c3)nc(-c3cccc(NC(=O)c4cccnc4)c3)nc2cc1OC.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20150038488A1,CCOC(=O)c1cc[nH]n1.COc1ccc(C(=O)CBr)cc1OC>>CCOC(=O)c1ccnn1CC(=O)c1ccc(OC)c(OC)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04156011,CS(=O)(=O)Cl.OCCOc1ccc(Oc2ccc(Cl)cc2)cc1>>CS(=O)(=O)OCCOc1ccc(Oc2ccc(Cl)cc2)cc1,,c1ccncc1,,Cl,,val
US20140343277A1,CN(C(=O)CCCl)c1ccccc1.Cn1c(=O)ccc2cc(OCCCNCc3ccncc3)ccc21>>CN(C(=O)CCN(CCCOc1ccc2c(ccc(=O)n2C)c1)Cc1ccncc1)c1ccccc1,,CCO,,C,C[O-].[Na+],val
US20020099047A1,CNCCN1c2ccccc2COc2ccccc21.CS(=O)(=O)OCCc1ccc(Cl)cc1>>CN(CCc1ccc(Cl)cc1)CCN1c2ccccc2COc2ccccc21,,CC#N,,[I-].[Na+],,val
US20050261177A1,CC(C)(C)OC(=O)N1CCC(O)CC1.CCBr>>CCOC1CCN(C(=O)OC(C)(C)C)CC1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US04160837,O=C(OCc1ccccc1)N1C[C@@H](Oc2ccccc2)[C@H](O)C1>>O[C@@H]1CNC[C@H]1Oc1ccccc1,[Pd],CCO,,,,val
US20030105081A1,COC(=O)c1c[nH]c2c1-c1ncccc1CN(Cc1ccccc1)C2.Nc1ccccn1>>O=C(Nc1ccccn1)c1c[nH]c2c1-c1ncccc1CN(Cc1ccccc1)C2,,ClCCl,,C[Al](C)C,,val
US20080051404A1,CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](N)C[C@@H]1O[Si](C)(C)C(C)(C)C.Clc1cccc(-c2nc3c(Cl)ncnc3[nH]2)c1>>CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](Nc2ncnc3[nH]c(-c4cccc(Cl)c4)nc23)C[C@@H]1O[Si](C)(C)C(C)(C)C,,CCO,,CCN(C(C)C)C(C)C,,val
US20090192176A1,CCCC[Sn](CCCC)(CCCC)C1=CCOCC1.Clc1nc(Cl)c2sccc2n1>>Clc1nc(C2=CCOCC2)c2sccc2n1,,C1CCOC1,,,,val
US04028385,CC(C)=CCCC(C)=CCCC(C)=CCBr.CCOC(=O)CC(=O)OCC>>CCOC(=O)C(CC=C(C)CCC=C(C)CCC=C(C)C)C(=O)OCC,,CCO,,O,[Na],val
US20120071512A1,CC1(c2cncc(Br)c2)OCCO1.CN1C(=O)Cc2cc(B3OC(C)(C)C(C)(C)O3)ccc21>>CN1C(=O)Cc2cc(-c3cncc(C4(C)OCCO4)c3)ccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20090069288A1,Nc1nc(-c2ccccc2)no1.O=C(Cl)c1ccccc1>>O=C(Nc1nc(-c2ccccc2)no1)c1ccccc1,,c1ccncc1,,,,val
US20130345123A1,CC(C)(SC(c1ccccc1)(c1ccccc1)c1ccccc1)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)NCCCCC=O>>CC1(C)S[C@H]2CCCCN2C(=O)[C@H]1NC(=O)OCC1c2ccccc2-c2ccccc21,,CCOC(C)=O,,ClCCl,O=C(O)C(F)(F)F,val
US20080269300A1,N#CCC#N.[N-]=[N+]=NCCOc1ccc(C=O)cc1>>N#CC(C#N)=Cc1ccc(OCCN=[N+]=[N-])cc1,,CCO,,C1CCNCC1,,val
US04963566,OCc1cccc2cccnc12>>OCc1cccc2c1NCCC2,O=[Pt],CO,,,,val
US20040082607A1,CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2ccccc2)c2cc(OC(C)(C)C(=O)O)ccc2c1=O.Cl>>CC(C)Cn1c(CN)c(-c2ccccc2)c2cc(OC(C)(C)C(=O)O)ccc2c1=O.Cl,,CCOC(C)=O,,,,val
US04299830,O=C(C1CC1)N1CCN2CC1Cc1ccc([N+](=O)[O-])cc12>>Nc1ccc2c(c1)N1CCN(C(=O)C3CC3)C(C2)C1,[Fe],CCO,O,Cl,O=C([O-])O.[Na+],val
US20090275590A1,CCOCn1c2c(c3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc31)CN(C(=O)OC(C)(C)C)CC2>>CCOCn1c2c(c3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc31)CNCC2,,CCO,CCOCC,Cl,,val
US04711900,CC(=O)OC(C)=O.CN(O)C(=O)c1ccc(CCCCc2ccncc2)cc1>>CC(=O)ON(C)C(=O)c1ccc(CCCCc2ccncc2)cc1,,c1ccncc1,,,,val
US20080071114A1,CCOC(=O)[C@@H]1C[C@H]1c1ccc(F)c(F)c1>>O=C(O)[C@@H]1C[C@H]1c1ccc(F)c(F)c1,,CO,,[Na+].[OH-],,val
US20090118283A1,CC(C)(C)OC(=O)NC(CNC(=O)OCc1ccccc1)c1ccc(C(=O)Nc2ccncc2)cc1>>CC(C)(C)OC(=O)NC(CN)c1ccc(C(=O)Nc2ccncc2)cc1,[Pd],CCO,O,CC(=O)O,,val
US20100137313A1,COc1ccc(CNS(=O)(=O)c2c(C)[nH]c(=O)[nH]c2=O)cc1>>Cc1[nH]c(=O)[nH]c(=O)c1S(N)(=O)=O,,O=C(O)C(F)(F)F,,,,val
US20040176385A1,BrBr.CCc1nc(Nc2cccnc2)cc(-c2cccc(OC)c2)n1>>COc1cccc(-c2cc(Nc3cccnc3)nc(CCBr)n2)c1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20150239842A1,CCOC(=O)c1nc(Cl)nc(Cl)c1C.C[C@H]1CN(C)CCN1>>CCOC(=O)c1nc(Cl)nc(N2CCN(C)C[C@@H]2C)c1C,,CCO,,CCN(C(C)C)C(C)C,,val
US20130131050A1,CCSc1nc2c(=O)n(Cc3ccc(OC)cc3OC)ccc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1>>CCSc1nc2c(=O)[nH]ccc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1,,O=CO,,,,val
US20080139631A1,BrBr.Cc1c(Cl)cccc1NC(=O)C(C)(C)C>>Cc1c(NC(=O)C(C)(C)C)ccc(Br)c1Cl,,CC(=O)O,,,,val
US20150065482A1,C#C[Mg]Br.O=C1CCc2cccnc21>>C#CC1(O)CCc2cccnc21,,C1CCOC1,C1CCOC1,,,val
US20100189773A1,CC1(c2ccc(Br)nc2)OCCO1.CN1CCC(=O)CC1>>CN1CCC(O)(c2ccc(C3(C)OCCO3)cn2)CC1,,C1CCOC1,,[Li]CCCC,,val
US06498172B1,COC(=O)CCc1cccc(CNCc2ccc(Oc3ccccc3)cc2)c1.CS(=O)(=O)Cl>>COC(=O)CCc1cccc(CN(Cc2ccc(Oc3ccccc3)cc2)S(C)(=O)=O)c1,,CCN(CC)CC,,,,val
US20140199263A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cc(-c4cc5ccccc5n4C(=O)OC(C)(C)C)nc(Cl)n3)cc12.CO[Na]>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cc(-c4cc5ccccc5[nH]4)nc(OC)n3)cc12,,CO,,O,,val
US20110263627A1,CI.Nc1nc(=O)n(S(=O)(=O)c2ccccc2)cc1F>>Cn1c(=N)c(F)cn(S(=O)(=O)c2ccccc2)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140315881A1,BrBr.CC(=O)c1ccncc1C>>Cc1cnccc1C(=O)CBr,,Br,CC(=O)O,,,val
US20100093654A1,CCc1ccc(Cc2cc(C3(O)O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)cc(O)c2C)cc1.OC1CCC1>>CCc1ccc(Cc2cc(C3(O)O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)cc(OC3CCC3)c2C)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080015187A1,COC(=O)c1nn2c(c1OCc1ccccc1)C(=O)N(C)CC2C(=O)O>>COC(=O)c1nn2c(c1OCc1ccccc1)C(=O)N(C)CC2CO,,C1CCOC1,,,,val
US04827004,CC(C)=CCC/C(C)=C\CC/C(C)=C/COC1CCCCO1.O>>C=C(C)C(O)CC/C(C)=C\CC/C(C)=C/COC1CCCCO1,,COCCOC,,O=C1CCC(=O)N1Br,,val
US04863904,CCOC(=O)C(CN)Cc1ccccc1.O=C(O)Cc1cccc2ccccc12>>CCOC(=O)C(CNC(=O)Cc1cccc2ccccc12)Cc1ccccc1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US06300352B1,CNC.O=C(O)Cc1cccc(Br)c1>>CN(C)C(=O)Cc1cccc(Br)c1,CN(C)c1ccncc1,C1CCOC1,ClCCl,,,val
US04772738,CCOC(OCC)P(=O)(CC(C[N+](=O)[O-])c1ccc(OC)cc1)OCC>>CCOC(OCC)P(=O)(CC(CN)c1ccc(OC)cc1)OCC,[Ni],CCO,,N,[H][H],val
US20050182103A1,COC(=O)c1cc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)nc1OCc1ccccc1>>O=C(O)c1cc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)nc1OCc1ccccc1,,CO,O,Cl,[Na+].[OH-],val
US20080269196A1,CC(C)(C)OC(=O)NCc1ccc(-c2cc(NCC3CC3)ncn2)cc1>>NCc1ccc(-c2cc(NCC3CC3)ncn2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060293307A1,O=C(NC[C@H]1CN(c2ccc(N3CCNCC3)c(F)c2)C(=O)O1)C(F)F.O=[N+]([O-])c1ccc(Br)s1>>O=C(NC[C@H]1CN(c2ccc(N3CCN(c4ccc([N+](=O)[O-])s4)CC3)c(F)c2)C(=O)O1)C(F)F,,CC#N,,CCN(C(C)C)C(C)C,,val
US04833146,CC(=O)Cn1cnc2c1c(=O)[nH]c(=O)n2C.CC(C)(O)CCCCCl>>CC(=O)Cn1cnc2c1c(=O)n(CCCCC(C)(C)O)c(=O)n2C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120184531A1,CC1NCCc2oc3c(Cl)cc(S(=O)(=O)c4ccccc4)cc3c21.Cl>>CC1NCCc2oc3c(Cl)cc(S(=O)(=O)c4ccccc4)cc3c21.Cl,,CO,,,,val
US20130172339A1,C1COCCN1.CCOC(=O)c1cccc(NS(=O)(=O)c2sc3ccc(Br)cc3c2C)c1>>CCOC(=O)c1cccc(NS(=O)(=O)c2sc3ccc(N4CCOCC4)cc3c2C)c1,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090093454A1,CCOC(=O)CC[C@H]1CCc2cccnc2[C@H]1N[C@@H](C)c1ccc(OC)cc1>>COc1ccc([C@H](C)N[C@@H]2c3ncccc3CC[C@@H]2CCCO)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04540699,CCOC(=O)CCc1ccnc(OC)c1>>CCOC(=O)CCc1ccnc(O)c1,,CCO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20150299121A1,C=O.Cc1c(CN2CCN(C(=O)C3CCCC3)[C@@H](C)C2)cc(F)cc1NC(=O)[C@H]1CCCN1>>Cc1c(CN2CCN(C(=O)C3CCCC3)[C@@H](C)C2)cc(F)cc1NC(=O)[C@H]1CCCN1C,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US08129538B1,C=CC(=O)OC.N[C@H](CO)CC(=O)N(Cc1cccc(Cl)c1Cl)C1CC1>>COC(=O)CCN[C@H](CO)CC(=O)N(Cc1cccc(Cl)c1Cl)C1CC1,,CO,,,,val
US05241107,COCCOc1ccc2c(c1)C(=O)c1ccccc1C2=O>>COCCOc1ccc2cc3ccccc3cc2c1,,CCCCCC,ClCCl,,,val
US20150232472A1,Cc1c(C(F)(F)F)nc2ccc(/C=C/c3nc(N4CCCC4)nn3C)nn12>>Cc1c(C(F)(F)F)nc2ccc(CCc3nc(N4CCCC4)nn3C)nn12,[Ni],CCO,,,,val
US05446057,CC1(C)COC(c2cccnc2)=N1.[Li]c1ccccc1>>CC1(C)COC(C2=CNC=CC2c2ccccc2)=N1,,C1CCOC1,,,,val
US20090069370A1,O=C(c1ccc(-c2ccc3c(c2)CCN([C@@H]2CCN(Cc4ccccc4)C2)C3=O)cc1)N1CCCC1>>O=C(c1ccc(-c2ccc3c(c2)CCN([C@@H]2CCNC2)C3=O)cc1)N1CCCC1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20120129852A1,N#Cc1c(Cl)cncc1-c1ccc(Oc2ccccc2)cc1.O=C(OO)c1cccc(Cl)c1>>N#Cc1c(Cl)c[n+]([O-])cc1-c1ccc(Oc2ccccc2)cc1,,ClCCl,,,,val
US20080269208A1,Cc1ccccc1-c1cc(Cl)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C1CC[C@H]2CNCCN12>>Cc1ccccc1-c1cc(N2CCN3C(=O)CC[C@H]3C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CS(C)=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US07176310B1,Nc1ccccc1.O=C(O)COc1ncc(C(=O)Nc2ccc(F)cc2)cn1>>O=C(COc1ncc(C(=O)Nc2ccc(F)cc2)cn1)Nc1ccccc1,,CO,ClCCl,,,val
US04751226,NN.O=C(O)Cc1ccccc1C(=O)CC(=O)c1ccccc1>>O=C1Cc2ccccc2-c2cc(-c3ccccc3)nn21,,CCO,,O,,val
US06586633B1,CN(Cc1ccc(C(C)(C)C)cc1)Cc1cc(Br)cc(C(C)(C)O)c1>>C=C(C)c1cc(Br)cc(CN(C)Cc2ccc(C(C)(C)C)cc2)c1,,c1ccncc1,,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US20020013460A1,CCN1CCN(c2nc(-c3ccc(OCCOCc4ccccc4)cc3OC)cc3ccccc23)CC1>>CCN1CCN(c2nc(-c3ccc(OCCO)cc3OC)cc3ccccc23)CC1,[Pd],CO,,Cl,,val
US05648373,OCCCCCCCCCBr.c1ccc(-c2nn[nH]c2-c2ccccc2)cc1>>OCCCCCCCCCn1nc(-c2ccccc2)c(-c2ccccc2)n1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130131040A1,N#Cc1ncc(N[C@@H]2CCCC(F)(F)[C@@H]2N)nc1Nc1ccc(-c2ccncc2)cc1.OO>>NC(=O)c1ncc(N[C@@H]2CCCC(F)(F)[C@@H]2N)nc1Nc1ccc(-c2ccncc2)cc1,,CCO,CS(C)=O,CC(=O)O,[Na+].[OH-],val
US20100234364A1,Nc1ccccc1C(=O)c1ccccc1.O=S(=O)(Cl)c1ccc(Cl)c(Cl)c1>>O=C(c1ccccc1)c1ccccc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1,,c1ccncc1,,,,val
US20140213578A1,NCCN1c2ccccc2CCc2ccc(Cl)cc21.O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>O=S(=O)(NCCN1c2ccccc2CCc2ccc(Cl)cc21)c1ccc(OC(F)(F)F)cc1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20110076291A1,CC(C)n1cnnc1-c1nc2c(s1)CCOc1cc(CO)ccc1-2>>CC(C)n1cnnc1-c1nc2c(s1)CCOc1cc(C=O)ccc1-2,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05149703,CO.O=C(O)c1cccc(C=C2COc3ccc(OCc4ccccc4)cc3C2=O)c1>>COC(=O)c1cccc(CC2COc3ccc(O)cc3C2=O)c1,[Pd],,,C1CCOC1,,val
US20070149561A1,BrC1CCCO1.CN(C)C=O.O=C(Nc1ccccc1)Nc1ccc(-c2n[nH]cc2Br)cc1>>O=C(Nc1ccccc1)Nc1ccc(-c2nn(CC3CCCO3)cc2Br)cc1,,CN(C)C=O,,C1CCOC1,CC(C)(C)[O-].[K+],val
US05003069,CCC(CC)c1cccc(-c2cccc(C(CC)CC)n2)n1.Nc1ccccn1>>CCC(CC)c1ccccn1,,c1ccncc1,,,,val
US20100144732A1,Clc1ncc(Cl)c(Cl)n1.O=[N+]([O-])c1ccccc1O>>O=[N+]([O-])c1ccccc1Oc1nc(Cl)ncc1Cl,,CCO,,CCN(C(C)C)C(C)C,,val
US04528195,O=C(O)CCC(=O)O.c1ccc2c(Cn3ccnc3)cccc2c1>>O=C(O)CCC(=O)O.c1ccc2c(Cn3ccnc3)cccc2c1,,CCO,,,,val
US04820834,CC(C)CC(=O)Cl.CN1C(=O)[C@@H](N)N=C(c2ccccc2)c2ccccc21>>CC(C)CC(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O,,ClCCl,,CCN(CC)CC,CCOCC,val
US04331670,Nc1nc(Cl)ccc1C(F)(F)F.O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(C(F)(F)F)c1>>O=[N+]([O-])c1cc([N+](=O)[O-])c(Nc2nc(Cl)ccc2C(F)(F)F)c(C(F)(F)F)c1,,CN(C)C=O,O,Cl,[K+].[OH-],val
US20020045615A1,COc1ccc(-c2nnn[nH]2)c2sc(N)nc12.O=C(Cl)c1ccc(F)cc1>>COc1ccc(-c2nnn[nH]2)c2sc(NC(=O)c3ccc(F)cc3)nc12,,c1ccncc1,,,,val
US20070173507A1,CC(=O)OC1(C)Cc2cc(-c3nnn(-c4cccnc4F)c3C)ccc2C1=O>>Cc1c(-c2ccc3c(c2)CC(C)(O)C3=O)nnn1-c1cccnc1F,,CCOC(C)=O,,C1CCOC1,[H-].[Na+],val
US20050209217A1,Cc1c([N+](=O)[O-])ccc(C(=O)O)c1Cc1ccccc1>>O=C(O)c1ccc([N+](=O)[O-])cc1Cc1ccccc1,,CO,,[Na+].[OH-],,val
US08569490B2,Br[Zn]C[Zn]C[Zn]Br.CC(C)(C)[Si](OC1CC(O)C(=O)C1COC(c1ccccc1)(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1>>C=C1C(O)CC(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C1COC(c1ccccc1)(c1ccccc1)c1ccccc1,Cl[Ti](Cl)(Cl)Cl,C1CCOC1,,,,val
US20110275797A1,CCOc1ccc(OC(C)=O)c(C(=O)Nc2cc(-c3ccccc3)ccc2C(=O)OC)c1>>CCOc1ccc(O)c(C(=O)Nc2cc(-c3ccccc3)ccc2C(=O)O)c1,,CO,,Cl,[Na+].[OH-],val
US20120157469A1,FC(F)(F)c1ccc(Cl)nc1.O=C1CNCCN1>>O=C1CN(c2ccc(C(F)(F)F)cn2)CCN1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20090048239A1,COC(CN(C)S(=O)(=O)NC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)C[C@@H](N(CCNC(=O)OC(C)(C)C)Cc1ccccc1)COc1cc(F)ccc1-3)OC>>CN(CC=O)S(=O)(=O)NC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)C[C@@H](N(CCN)Cc1ccccc1)COc1cc(F)ccc1-3,,C1CCOC1,,Cl,,val
US20060046980A1,COC(=O)c1cc(C)c(Oc2ccc(OC)c(C(C)C)c2)c(C)c1>>COc1ccc(Oc2c(C)cc(C(=O)O)cc2C)cc1C(C)C,,CO,,Cl,[Na+].[OH-],val
US05698526,CCOC(=O)[C@@H]1C[C@H]1C(=O)O.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCOC(=O)[C@@H]1C[C@H]1N=C=O,,Cc1ccccc1,,CCN(CC)CC,,val
US20020016337A1,CCC(=O)N(c1ccccc1)C1CCCN(Cc2ccccc2)C1>>CCC(=O)N(c1ccccc1)C1CCCNC1,[Pd],CO,,,,val
US04093739,O=C(CCl)Nc1cccc(C(=O)O)c1.O=S(Cl)Cl>>O=C(CCl)Nc1cccc(C(=O)Cl)c1,c1ccncc1,ClC(Cl)Cl,,,,val
US05091432,CCOC(=O)c1ccc(N)cc1.O=C(CCn1cnc2c(=O)[nH]cnc21)Oc1ccc([N+](=O)[O-])cc1>>CCOC(=O)c1ccc(NC(=O)CCn2cnc3c(=O)[nH]cnc32)cc1,,CS(C)=O,,CC(C)=O,,val
US20130281366A1,CCOC(=O)COc1ccc2c(c1)c(C=NOCc1ccc(C(F)(F)F)cc1)cn2Cc1ccc(C(F)(F)F)cc1>>O=C(O)COc1ccc2c(c1)c(C=NOCc1ccc(C(F)(F)F)cc1)cn2Cc1ccc(C(F)(F)F)cc1,,C1CCOC1,,O,[Li+].[OH-],val
US04942226,CCNCCN.O=CC(=O)O>>CCNCCNCC(=O)O,[Pd],CCO,,O,[H][H],val
US20120040948A1,CC(C)(C)OC(=O)NCCBr.CCOC(=O)NC1Cc2ccc(O)cc2C1Cc1ccccc1>>CCOC(=O)NC1Cc2ccc(OCCN)cc2C1Cc1ccccc1,,CC#N,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100267722A1,COC(=O)C1CC(O)CN1.O=[N+]([O-])c1ccccc1Cl>>COC(=O)[C@@H]1C[C@H](O)CN1c1ccccc1[N+](=O)[O-],,CC#N,,Cl,Cl,val
US20160068510A1,CON(C)C(=O)c1ccnc(F)c1.C[C@@H]1CC[C@@H](O)CN1C(=O)c1ccccc1-n1nccn1.O>>CC1CCC(Oc2cc(C(=O)O)ccn2)CN1C(=O)c1ccccc1-n1nccn1,,CN(C)C=O,,[H-].[Na+],,val
US20100173888A1,COC(=O)C[C@@H]1CC[C@H](NC(=O)c2ccc(-c3cccc(F)c3)nc2)CC1>>O=C(O)C[C@@H]1CC[C@H](NC(=O)c2ccc(-c3cccc(F)c3)nc2)CC1,,CO,,[Na+].[OH-],,val
US20090176794A1,CNc1ccccn1.Nn1ccc2ccccc21.O=C(n1ccnc1)n1ccnc1>>O=C(NCc1ccccn1)Nn1ccc2ccccc21,,C1CCOC1,,,,val
US05591762,CCCCc1nc2c(C)ccc(OCCn3cnc4ccccc43)c2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCCc1nc2c(C)ccc(OCCn3cnc4ccccc43)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090082390A1,COC(=O)CC1CCCCN1C(=O)OC(C)(C)C.NN>>CC(C)(C)OC(=O)N1CCCCC1CC(=O)NN,,CCO,,O,,val
US05326780,Cc1nc(C(C)C)c(Cc2ccccc2)[nH]1.ClCOCc1ccccc1>>Cc1nc(C(C)C)c(Cc2ccccc2)n1COCc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20060257987A1,CCC(O)CCOc1ccc(CCC(=O)OC)c(C)c1.CS(=O)(=O)Cl>>CCC(CCOc1ccc(CCC(=O)OC)c(C)c1)OS(C)(=O)=O,,ClCCl,,,,val
US20030144263A1,CC(C)(C)[Si](C)(C)OCc1cn(-c2ccc(N3C[C@H](COc4ccon4)OC3=O)cc2F)cn1>>O=C1O[C@@H](COc2ccon2)CN1c1ccc(-n2cnc(CO)c2)c(F)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160096832A1,COc1ccc(I)cc1.Cc1cc[nH]c(=O)c1N1CCc2nc(N)ncc2C1>>COc1ccc(-n2ccc(C)c(N3CCc4nc(N)ncc4C3)c2=O)cc1,I[Cu]I,CN1CCCC1=O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20030004156A1,CS(=O)(=O)Cl.Cc1ccc(S(=O)(=O)N2CCc3cc(C#CCCCO)c(F)cc32)cc1>>Cc1ccc(S(=O)(=O)N2CCc3cc(C#CCCCOS(C)(=O)=O)c(F)cc32)cc1,,CCOCC,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20080312226A1,O=C(OCC(Cl)(Cl)Cl)N(C(=O)OCC(Cl)(Cl)Cl)c1noc2ncccc12.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>O=C(Nc1noc2ncccc12)N1CCN(c2nc(-c3ccccc3)ns2)CC1,,O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US04943574,CC(O)c1ccc(Cl)c([N+](=O)[O-])c1.O=C(n1ccnc1)n1ccnc1>>CC(c1ccc(Cl)c([N+](=O)[O-])c1)n1ccnc1,,C1CCOC1,,,,val
US04508561,CI.O=S(=O)(Cc1cc(Cl)ccc1OCC(F)(F)F)c1cccc[n+]1[O-]>>CC(c1cc(Cl)ccc1OCC(F)(F)F)S(=O)(=O)c1cccc[n+]1[O-],,CN(C)C=O,,[H-].[Na+],,val
US20080261946A1,N#Cc1oc2ccc(Cl)cc2c1N.O=S(=O)(O)O>>NC(=O)c1oc2ccc(Cl)cc2c1N,,O=S(=O)(O)O,,O,,val
US20090281149A1,O=C(NCCOc1cccc(C#CC2(O)CCCCCC2)c1)C(F)(F)F>>NCCOc1cccc(C#CC2(O)CCCCCC2)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20100249168A1,CO.O=C(O)CCCCCCCCCCBr>>COC(=O)CCCCCCCCCCBr,Cl,,,,,val
US20040242572A1,COC(=O)[C@@H]1CCCN1.CS(=O)(=O)OCc1ccc(CCNC(=O)c2ccc(-c3ccc(Cl)cc3)cc2)cc1>>COC(=O)[C@@H]1CCCN1Cc1ccc(CCNC(=O)c2ccc(-c3ccc(Cl)cc3)cc2)cc1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20150336986A1,COc1ccc(COCC2CO2)cc1.NC(N)=S>>COc1ccc(COCC2CS2)cc1,,CO,,,,val
US08101665B2,CC(C)(C)O.O=C(O)C(CS)Cc1cccc(Br)c1>>CC(C)(C)SCC(Cc1cccc(Br)c1)C(=O)O,,CC(C)(C)O,,Cl,,val
US20100041642A1,CC(C)(C)C(=CC#N)OCC(=O)O.CN1CCNC(C)(C)C1=O>>CN1CCN(C(=O)COC(=CC#N)C(C)(C)C)C(C)(C)C1=O,,ClCCl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20060194836A1,O=C(Nc1ccc(Cl)cc1)c1cccnc1Cl.SCCc1ccncc1>>O=C(Nc1ccc(Cl)cc1)c1cccnc1SCCc1ccncc1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20100305133A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.COC(=O)c1c(OC)c(Br)cc2[nH]c(=O)cnc12>>COC(=O)c1c(OC)c(-c2ccccn2)cc2[nH]c(=O)cnc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20080167453A1,CN(CC[N+](C)(C)C)c1ccccc1[N+](=O)[O-].COS(=O)(=O)[O-]>>CN(CC[N+](C)(C)C)c1ccccc1N.COS(=O)(=O)[O-],[Pd],O,,,,val
US20110184188A1,CCOC(=O)c1cn(Cc2ccc([N+](=O)[O-])c(C)c2)nc1C(F)(F)C(F)(F)F>>Cc1cc(Cn2cc(C(=O)O)c(C(F)(F)C(F)(F)F)n2)ccc1[N+](=O)[O-],,CCO,,[Na+].[OH-],,val
US20160263122A1,CC1CN(C)CCN1.O=C(CCl)Nc1cc(C(=O)Nc2nnc(-c3ccccc3)s2)ccc1OC(F)(F)F>>CC1CN(C)CCN1CC(=O)Nc1cc(C(=O)Nc2nnc(-c3ccccc3)s2)ccc1OC(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,[I-].[K+],val
US20050032796A1,CC(=O)c1ccccc1F.COC(=O)c1ccc(O)c(OC)c1>>COC(=O)c1ccc(Oc2ccccc2C(C)=O)c(OC)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110281843A1,CO.Cc1cc(F)ccc1C(=O)O>>COC(=O)c1ccc(F)cc1C,O=S(=O)(O)O,,,,,val
US20060270692A1,CC(C)(C)OC(=O)Cn1cc([N+](=O)[O-])cn1>>CC(C)(C)OC(=O)Cn1cc(N)cn1,[Pd],CO,,,,val
US20050101592A1,O=C(O)c1nn(-c2ccccc2Cl)c(-c2ccc(Cl)cc2)c1NCC1CCCN1>>O=C1c2nn(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)c2NCC2CCCN12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040082571A1,CCCc1n[nH]c(C(F)(F)F)c1Cl.COc1cc(N2CCN(C(C)=O)CC2)ccc1Cl>>CCCc1nn(CC(=O)N2CCN(c3ccc(Cl)c(OC)c3)CC2)c(C(F)(F)F)c1Cl,,CCCCCC,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05290933,CCCOc1ccccc1-c1ncc([N+](=O)[O-])c(=O)[nH]1>>CCCOc1ccccc1-c1ncc(N)c(=O)[nH]1,[Pd],CO,,[H][H],,val
US20090054405A1,CC(=O)Nc1nc2ccc(-c3ccnc(Cl)n3)cc2s1.NN1CCCCC1>>CC(=O)Nc1nc2ccc(-c3ccnc(N4CCCCC4)n3)cc2s1,,CS(C)=O,,,,val
US20050267104A1,CC(=O)N(C[C@H]1CN(c2ccc(C3CCS(=O)(=O)CC3)c(F)c2)C(=O)O1)C(=O)OCOC(=O)[C@H](C)NC(=O)OC(C)(C)C.Cl>>CC(=O)N(C[C@H]1CN(c2ccc(C3CCS(=O)(=O)CC3)c(F)c2)C(=O)O1)C(=O)OCOC(=O)[C@H](C)N.Cl,,C1CCOC1,,COc1ccccc1,,val
US20110082133A1,CC(C)(C)OC(=O)c1ccc(CCn2c(CBr)c(Cl)cc(Cl)c2=O)cc1.CNc1ncc(C)s1>>Cc1cnc(N(C)Cc2c(Cl)cc(Cl)c(=O)n2CCc2ccc(C(=O)OC(C)(C)C)cc2)s1,,CCOC(C)=O,O,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US20090264416A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)CC1.O=C(O)C(F)(F)F>>O=C(Nc1ccccc1)Nc1ccc(C(=O)N2CCNCC2)cc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20070167486A1,C=CCCBr.COc1ccc(CN)c(OC)c1>>C=CCCNCc1ccc(OC)cc1OC,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140329807A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C(=O)O)CC1>>N[C@@H]1CC[C@@H](C(=O)O)CC1,,CCOC(C)=O,,Cl,,val
US20130217664A1,COc1cc(C2CCNCC2)ccc1N(C)c1cc2c(cn1)ncn2C.N#CCC(=O)O>>COc1cc(C2CCN(C(=O)CC#N)CC2)ccc1N(C)c1cc2c(cn1)ncn2C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040019016A1,BrCCCCCBr.N#Cc1ccc(Nn2cnnc2)cc1>>N#Cc1ccc(N(CCCCCBr)n2cnnc2)cc1,,CS(C)=O,,CCOC(C)=O,[H-].[Na+],val
US06521643B1,Cc1ccnc(-n2cnc(N=C(NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)c2)c1.Cl.ClCCl>>Cc1ccnc(-n2cnc(NC(=N)N)c2)c1.Cl.Cl,,C1COCCO1,ClCCl,,,val
US20160251339A1,C=O.O=S(=O)(c1ccc(OCC(F)(F)F)c(N2CCNCC2)c1)n1cc(C(F)F)c2ccc(F)cc21>>CN1CCN(c2cc(S(=O)(=O)n3cc(C(F)F)c4ccc(F)cc43)ccc2OCC(F)(F)F)CC1,,CO,,[BH3-]C#N.[Na+],,val
US05998438,CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(C3CCC=CO3)cc12>>CN(C)CCc1c[nH]c2ccc(C3CCC=CO3)cc12,,CO,,[K+].[OH-],,val
US20120077799A1,Nc1ncccc1-c1ccc(OCc2ccccc2)c(F)c1>>Nc1ncccc1-c1ccc(O)c(F)c1,O=[Pt]=O,CCO,,,,val
US20160024053A1,CO.CSc1cn(-c2ncc(-c3ccccc3)cn2)c2cc(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)ccc12>>CS(=O)c1cn(-c2ncc(-c3ccccc3)cn2)c2cc(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)ccc12,,ClCCl,,,,val
US20140142122A1,CC(=O)CC(=O)C(F)(F)F.Nc1nc(CCCOc2ccc(Cl)cc2)n[nH]1>>Cc1cc(C(F)(F)F)n2nc(CCCOc3ccc(Cl)cc3)nc2n1,,CC(=O)O,,,,val
US20080033002A1,CCC(CC)NC(=O)C1=CC2(CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21>>CCC(CC)NC(=O)C1=CC2(CCNCC2)c2ccccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US03947466,O=C(c1ccccc1F)c1cc(Br)ccc1-n1c(CN2C(=O)c3ccccc3C2=O)nnc1CN1C(=O)c2ccccc2C1=O>>NCc1nnc2n1-c1ccc(Br)cc1C(c1ccccc1F)=NC2,,CCO,,NN,O,val
US20050004164A1,CC(C)(C)OC(=O)C(C#N)=Cc1cccc2ccccc12.CC(C)c1ccccc1Br>>CC(C)c1ccccc1C(c1cccc2ccccc12)C(C#N)C(=O)OC(C)(C)C,[Cu]I,C1CCOC1,,[Li]CCCC,,val
US06013841,COS(=O)(=O)OC.Cc1ccc(O)c(O)c1>>COc1ccc(C)cc1OC,,O,,Cc1ccccc1,[Na+].[OH-],val
US04990505,C1CO1.CCSc1ccc(Br)cc1>>CCSc1ccc(CCO)cc1,,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US20110301142A1,COC(=O)Cc1ccc(Cl)nc1.Cc1noc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c1NC(=O)OC(C)c1ccccc1Cl>>Cc1noc(-c2ccc(-c3ccc(CC(=O)O)cn3)cc2)c1NC(=O)OC(C)c1ccccc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20140221435A1,Cc1cc(F)ccc1Oc1ccc(C(F)(F)F)cc1C(=O)Nc1ccc(C(=O)OC(C)(C)C)cc1>>Cc1cc(F)ccc1Oc1ccc(C(F)(F)F)cc1C(=O)Nc1ccc(C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040242884A1,CNCC(O)c1ccc(CO)cc1.Cc1c(CCl)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12>>Cc1c(CN(C)CC(O)c2ccc(CO)cc2)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20100222302A1,CS(=O)(=O)OC[C@H]1CN(c2ccc(OCc3ccccc3)c(F)c2)C(=O)O1.c1cn[nH]c1>>O=C1O[C@@H](Cn2cccn2)CN1c1ccc(OCc2ccccc2)c(F)c1,,CCOC(C)=O,,[H-].[Na+],,val
US04417050,ClCc1ccc(-c2ccccc2)cc1.OCc1cc(-c2ncccn2)c(Cl)cc1Cl>>Clc1cc(Cl)c(-c2ncccn2)cc1COCc1ccc(-c2ccccc2)cc1,,O,,C1CCOC1,[H-].[Na+],val
US20100105700A1,CCCC[Sn](CCCC)(CCCC)c1cnccn1.CCN1C(=O)CC[C@@]2(C)C1=CC[C@H]1[C@@H]3CC=C(OS(=O)(=O)C(F)(F)F)[C@@]3(C)CC[C@@H]12>>CCN1C(=O)CC[C@@]2(C)C1=CC[C@H]1[C@@H]3CC=C(c4cnccn4)[C@@]3(C)CC[C@@H]12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20050227997A1,CC(C)(C)OC(=O)C1N(S(=O)(=O)c2ccc(O)cc2)CCCC1(C)O.CCOC(C)=O.CN(C)C=O>>CC(C)OC(C)C.CCCCCC,,CCOC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05597929,CCOC(=O)Cl.CCOC(=O)c1nnn[nH]1>>CCOC(=O)c1nnnn1C(=O)OCC,,ClCCl,,CCN(CC)CC,O,val
US04500540,CCCCC[C@H](O)/C=C/[C@H]1[C@H]2C[C@H](OO2)[C@@H]1C/C=C\CCCC(=O)O.CCOCC>>CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC,,CCOCC,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US20130096144A1,COC(=O)c1ncc(Br)cc1CBr.N[C@@H](Cc1cccc(F)c1)CN1C(=O)c2ccccc2C1=O>>O=C1c2ccccc2C(=O)N1C[C@H](Cc1cccc(F)c1)N1Cc2cc(Br)cnc2C1=O,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20070043066A1,COC(=O)CCC(NC(=O)c1ccc(-c2ccccc2)cc1)C(=O)OC(C)(C)C>>COC(=O)CCC(NC(=O)c1ccc(-c2ccccc2)cc1)C(=O)O,,CC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20020002187A1,Cc1sc2c(I)c3ccccc3c(-c3ccc(OS(C)(=O)=O)cc3)c2c1C.Sc1ccccc1>>Cc1sc2c(Sc3ccccc3)c3ccccc3c(-c3ccc(O)cc3)c2c1C,,CN(C)C=O,O,Cl,[Na+].[OH-],val
US20090054392A1,O.O=Cc1nccc(-c2ccc3ccccc3c2)n1>>O=C(O)c1nccc(-c2ccc3ccccc3c2)n1,,CO,,[Na+].[O-]Cl,,val
US20080021022A1,COc1ccc(-c2oncc2C(=O)O)cc1.c1ccc(C2CCNC2)cc1>>COc1ccc(-c2oncc2C(=O)N2CCC(c3ccccc3)C2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US04405552,Cc1nc(Cl)c(C#N)c(C)c1-c1ccccc1.N>>Cc1nc(N)c(C#N)c(C)c1-c1ccccc1,,CS(C)=O,,,,val
US20160264567A1,FC(F)(F)c1cnc(Cl)nc1Cl.N>>Nc1nc(Cl)ncc1C(F)(F)F,,C1CCOC1,O,,,val
US20130053366A1,Cc1ccc2c(c1)c1c(n2C2=C(Br)CCC2)CCN(C)C1.OB(O)c1cc2ccccc2s1>>Cc1ccc2c(c1)c1c(n2C2=C(c3cc4ccccc4s3)CCC2)CCN(C)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[K+].[K+],val
US20080090782A1,NO.O=Cc1ccc(N2CCOCC2)cc1O>>ON=Cc1ccc(N2CCOCC2)cc1O,,c1ccncc1,,Cl,,val
US20060270653A1,CN(C)C(=O)Cl.O=C(O[C@@H]1CCOC1)N1C2CCC1CC(N1CCC3(CC1)CNCc1ccccc13)C2>>CN(C)C(=O)N1Cc2ccccc2C2(CCN(C3CC4CCC(C3)N4C(=O)O[C@@H]3CCOC3)CC2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070232591A1,CCOC(=O)c1cnc2c(c1)CCN(CC(=O)OC(C)(C)C)C2.Cl>>CCOC(=O)c1cnc2c(c1)CCN(CC(=O)O)C2.Cl,,C1COCCO1,,,,val
US20070082912A1,Fc1ccc(CBr)cc1.O=Cc1cc(F)ccc1O>>O=Cc1cc(F)ccc1OCc1ccc(F)cc1,,CCOC(C)=O,CN(C)C=O,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20120040981A1,CC(C)(C)OC(=O)n1cc(B2OC(C)(C)C(C)(C)O2)cn1.CC1(C)NC(=O)c2sc(Br)cc2N1CC(=O)N1CCOCC1>>CC1(C)NC(=O)c2sc(-c3cn[nH]c3)cc2N1CC(=O)N1CCOCC1,,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20080171772A1,BrCCCCBr.CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(N)cc2n1Cc1ccccn1>>CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(N3CCCC3)cc2n1Cc1ccccn1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US20120010183A1,CS(N)(=O)=O.Cc1ccc(OC(=O)c2cc(Cl)c(Oc3cnc(O[C@@H](C)C(F)(F)F)c(Cl)c3)cc2F)cc1>>C[C@H](Oc1ncc(Oc2cc(F)c(C(=O)NS(C)(=O)=O)cc2Cl)cc1Cl)C(F)(F)F,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20150329542A1,CN(c1ccc(Cl)cc1CNC(=O)OC(C)(C)C)S(C)(=O)=O.Cl>>CN(c1ccc(Cl)cc1CN)S(C)(=O)=O.Cl,,C1COCCO1,CO,,,val
US20110086882A1,COB(OC)OC.COc1cc(C(C)OC)cc(OC)c1Br>>COc1cc(C(C)OC)cc(OC)c1B(O)O,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20050054626A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@H](NC(=O)OCc2ccccc2)[C@H](C(N)=O)C1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](NC(=O)OCc2ccccc2)[C@H](C(N)=S)C1,,C1CCOC1,,,,val
US20160272596A1,CCN(C(=O)OC(C)(C)C)[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc(C(C)=O)cc2)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O.Cl>>CCN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc(C(C)=O)cc2)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O.Cl,,C1COCCO1,CO,,,val
US20060004013A1,C[O-].O=[N+]([O-])c1ccc(Cl)nc1Cl>>COc1nc(Cl)ccc1[N+](=O)[O-],,C1CCOC1,,[Cl-].[NH4+],,val
US05576321,Clc1cccc2cc[nH]c12.O=C1CCNCC1>>Clc1cccc2c(C3=CCNCC3)c[nH]c12,,CO,O,Cl,[K+].[OH-],val
US20140031373A1,CC(C)(C)C(=O)CBr.Oc1ccc(OC(F)(F)F)cc1>>CC(C)(C)C(=O)COc1ccc(OC(F)(F)F)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04935431,CCOC=C(C(=O)OCC)C(=O)OCC.COc1cscc1N>>CCOC(=O)C(=CNc1cscc1OC)C(=O)OCC,,Cc1ccccc1,,,,val
US20120071450A1,CN1C(=O)c2c(nn(Cc3ccc(-c4ccccn4)cc3)c2Nc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CN1C(=S)c2c(nn(Cc3ccc(-c4ccccn4)cc3)c2Nc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12,,c1ccncc1,,,,val
US20060074119A1,COC(=O)c1sc(-n2cnc3ccccc32)cc1NC(=O)OCc1ccccc1.FC(F)(F)c1ccccc1CBr>>COC(=O)c1sc(-n2cnc3ccccc32)cc1N(Cc1ccccc1C(F)(F)F)C(=O)OCc1ccccc1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20050085520A1,C[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)NCCC(C)(C)C>>C[C@H](C[C@H](O)[C@@H](N)Cc1ccccc1)C(=O)NCCC(C)(C)C,,C1COCCO1,,Cl,,val
US20060122064A1,BrCc1ccccc1.COc1cc(C=O)cc(F)c1O>>COc1cc(C=O)cc(F)c1OCc1ccccc1,,CCOC(C)=O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20040006099A1,CCOC(=O)C1(CCC2OCCO2)CCN(C(=O)OCc2ccccc2)CC1>>CCOC(=O)C1(CCC=O)CCN(C(=O)OCc2ccccc2)CC1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20100173880A1,Nc1ccccc1.O=C(O)C(Br)c1ccc(Cl)cc1>>O=C(O)C(Nc1ccccc1)c1ccc(Cl)cc1,,CC#N,,,,val
US20090156593A1,CC(C)(C)C(=O)Nc1ccc(C(F)(F)F)cn1.II>>CC(C)(C)C(=O)Nc1ncc(C(F)(F)F)cc1I,,C1CCOC1,,CN(C)CCN(C)C,[Li]CCCC,val
US20100063068A1,COCOc1ccc(OCc2ccccc2)nc1.II>>COCOc1cnc(OCc2ccccc2)cc1I,,C1CCOC1,,[Li]C(C)(C)C,,val
US20140088101A1,COC(=O)C=CC(C(=O)OC)=C(C)NCC1CCOCC1.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Br)c(=O)n(CC2CCOCC2)c1C,,CO,,C[O-].[Na+],,val
US20090275590A1,CC(C)(C)OC(=O)N1CCc2c([nH]c3ccc(Br)cc23)C1.CI>>Cn1c2c(c3cc(Br)ccc31)CCN(C(=O)OC(C)(C)C)C2,,CN(C)C=O,ClCCl,[H-].[Na+],,val
US04973599,O=[N+]([O-])c1ccc(F)cc1.Sc1nccn1-c1ccccc1>>O=[N+]([O-])c1ccc(Sc2nccn2-c2ccccc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20070027168A1,CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1ncccc1C#N)c(=O)n2C.Cl>>CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1ncccc1C#N)c(=O)n2C.Cl,,CC(C)O,CO,,,val
US20130217664A1,CCc1cc(C2CNC2)ncc1N(C)c1cc2c(cn1)ncn2C.O=C(OC(=O)C(F)F)C(F)F>>CCc1cc(C2CN(C(=O)C(F)F)C2)ncc1N(C)c1cc2c(cn1)ncn2C,,ClCCl,O,,,val
US20080085890A1,O=[N+]([O-])c1ccc(O)c(O)c1>>Nc1ccc(O)c(O)c1,[Ni],CO,,NN,,val
US20080214641A1,COc1cc2cnn(-c3ccc(F)cc3)c2cc1Cl>>Oc1cc2cnn(-c3ccc(F)cc3)c2cc1Cl,,ClCCl,,BrB(Br)Br,,val
US20150011530A1,Nc1ncnc2[nH]nc(-c3ccc(Oc4ccccc4)cc3)c12.O=C(OCc1ccccc1)N1CCCC2(CC(O)C2)C1>>Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CC2(CCCN(C(=O)OCc3ccccc3)C2)C1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040044211A1,CN1Cc2c(Cl)cc(Cl)cc2C(c2ccc(Br)cc2)C1.Cl>>CN1Cc2c(Cl)cc(Cl)cc2C(c2ccc(Br)cc2)C1.Cl,,Cl,,,,val
US20080166359A1,CC(C)(C)OC(=O)N1CCCCC1C1(O)CN(C(=O)OCc2ccccc2)C1.CO[C@](C(=O)Cl)(c1ccccc1)C(F)(F)F>>CO[C@@](C(=O)OC1([C@H]2CCCCN2C(=O)OC(C)(C)C)CN(C(=O)OCc2ccccc2)C1)(c1ccccc1)C(F)(F)F,CN(C)c1ccncc1,ClCCl,,,,val
US20050075317A1,CCOP(=O)(OCC)C(N)P(=O)(OCC)OCC.O=Cc1ccccn1>>CCOP(=O)(OCC)C(NCc1ccccn1)P(=O)(OCC)OCC,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050119282A1,CC(O)c1c(Cl)nc(N)nc1Cl>>CC(=O)c1c(Cl)nc(N)nc1Cl,O=[Mn]=O,ClCCCl,,,,val
US20120232068A1,O=Cc1cncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)c1>>OCc1cncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)c1,,CCO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20110124626A1,CC(C)(C)OC(=O)N1CCc2ccc(CS(=O)(=O)c3ccccc3)cc2CC1>>O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccccc1,,CO,ClCCl,C1COCCO1,Cl,val
US20150252038A1,CC(C)(C)OC(=O)N1CCC(F)(C(=O)O)CC1>>CC(C)(C)OC(=O)N1CCC(F)(CO)CC1,,C1CCOC1,,[Cl-].[NH4+],,val
US06111115,COC(=O)Cc1cc(C(C)C(=O)OC)ccc1Sc1ccccc1C(=O)OC>>COC(=O)C(C)c1ccc2c(c1)C(C(=O)OC)C(=O)c1ccccc1S2,,Cc1ccccc1,,CC(C)(C)[O-].[K+],,val
US20090181068A1,CCCCCCCCCCCCCCCC(=O)O.CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5>>CCCCCCCCCCCCCCCC(=O)[O-].CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5,,CN1CCCC1=O,,,,val
US05001157,Cc1ccc(C(=O)N=C=S)cc1.Cc1ccc(N)c(C(N)=O)c1>>Cc1ccc(C(=O)NC(=S)Nc2ccc(C)cc2C(N)=O)cc1,,CCOCC,,,,val
US20140163002A1,CC(C)(C)[S@](N)=O.O=Cc1nccc(Cl)c1F>>CC(C)(C)[S@](=O)/N=C/c1nccc(Cl)c1F,,CCOC(C)=O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150018422A1,COc1ccc(F)c(B(O)O)c1.Oc1ccc(Br)c(O)c1>>COc1ccc(F)c(-c2ccc(O)cc2O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCCCO,,O,O=C([O-])[O-].[Na+].[Na+],val
US20080096940A1,CC(C)Cc1ccc2c(c1)C[C@@H](NC(=O)OCc1ccccc1)C2>>CC(C)Cc1ccc2c(c1)C[C@@H](N)C2,[Pd],CO,,,,val
US20110152240A1,CS(=O)(=O)c1cc(NC2CC2)n2ncc(/C=C3\NC(=O)NC3=O)c2n1.C[C@H](N)c1cccc(Cl)c1>>C[C@H](Nc1cc(NC2CC2)n2ncc(/C=C3\NC(=O)NC3=O)c2n1)c1cccc(Cl)c1,,CN1CCCC1=O,,,,val
US20120022082A1,COCCCN.CS(=O)(=O)OCCc1ccc(-c2cnc(N)c(C(=O)Nc3cccnc3)n2)cc1>>COCCCNCCc1ccc(-c2cnc(N)c(C(=O)Nc3cccnc3)n2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160030395A1,Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCN(C(=O)OC(C)(C)C)CC1)C(=O)N2>>Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCNCC1)C(=O)N2,,ClCCl,O,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20160016948A1,CC(C)n1cnc2cnc(Nc3ccnc(C4=CC[NH2+]CC4)n3)cc21.CS(=O)(=O)Cl>>CC(C)n1cnc2cnc(Nc3ccnc(C4=CCN(S(C)(=O)=O)CC4)n3)cc21,,C1CCOC1,,CCN(CC)CC,,val
US20100234395A1,CCBr.COc1ccc(-c2nc(C3CCN(C(=O)NO)CC3)oc2-c2ccc(OC)cc2)cc1>>CCN(O)C(=O)N1CCC(c2nc(-c3ccc(OC)cc3)c(-c3ccc(OC)cc3)o2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04657909,CN(C)CCN.COC(=O)c1ccc(O)c2nc3c(C=O)c(O)c(C)c(O)c3nc12>>COC(=O)c1ccc(O)c2nc3c(C=NCCN(C)C)c(O)c(C)c(O)c3nc12,,C1CCOC1,,,,val
US05998433,CN(C)Cc1cc2c(o1)CN(C(=O)c1cccc(C(=O)c3ccccc3)c1)CC2.Cl>>CN(C)Cc1cc2c(o1)CN(C(=O)c1cccc(C(=O)c3ccccc3)c1)CC2.Cl,,CCOC(C)=O,CO,,,val
US20140349987A1,CC(=O)C1(C)CC1.COC(=O)OC>>COC(=O)CC(=O)C1(C)CC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US06670366B1,C=CS(=O)(=O)C=C.NCc1ccccc1>>O=S1(=O)CCN(Cc2ccccc2)CC1,,CCO,,,,val
US04241052,C=CCN(C(=O)N(CCCl)N=O)C1OC[C@H](O)[C@H](O)[C@H]1O.O=C(OO)c1cccc(Cl)c1>>O=NN(CCCl)C(=O)N(CC1CO1)C1OC[C@H](O)[C@H](O)[C@H]1O,,c1ccccc1,,ClCCl,,val
US20040209908A1,CCN(CC)CC.O=C(OCc1ccccc1)[C@H](CCc1nc(-c2ccccc2)c[nH]1)NCc1c[nH]c2ccccc12.O=[N+]([O-])c1ccc(N=C=S)cc1>>CN(C)CCCCCCN=C=S,,C1CCOC1,,,,val
US20040162303A1,CCSc1ncc(C(=O)c2cc(C)ccc2OC)c(N)n1.O=C(OO)c1cccc(Cl)c1>>CCS(=O)c1ncc(C(=O)c2cc(C)ccc2OC)c(N)n1,,ClC(Cl)Cl,ClCCl,,,val
US20080261978A1,CCN(CC)CCOc1ccc(NS(=O)(=O)c2ccc(C=NCCCN3CCOCC3)cc2)cc1>>CCN(CC)CCOc1ccc(NS(=O)(=O)c2ccc(CNCCCN3CCOCC3)cc2)cc1,,CO,,[BH4-].[Na+],,val
US20140213578A1,N#Cc1ccc(S(=O)(=O)Cl)cc1.NCCCN1c2ccccc2CCc2ccc(Cl)cc21>>N#Cc1ccc(S(=O)(=O)NCCCN2c3ccccc3CCc3ccc(Cl)cc32)cc1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20070010511A1,CC(=O)NCCc1c[nH]c2ccccc12.COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCCOS(=O)(=O)c2ccc(C)cc2)cc1>>COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCCn2cc(CCNC(C)=O)c3ccccc32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20090029965A1,CC(C)(C)OC(=O)N1CCN(CCO)CC1.COC(=O)c1ccc(O)c(C)c1>>COC(=O)c1ccc(OCCN2CCN(C(=O)OC(C)(C)C)CC2)c(C)c1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070023628A1,O=C(CN1CCCCC1)OCc1ccccc1>>O=C(O)CN1CCCCC1,[Pd],CO,,,,val
US20090239847A1,Cc1cnc2c(O)nc(O)nc2n1.[OH-]>>Cc1cnc(C(=O)O)c(N)n1,,O,,Cl,,val
US20150104384A1,CC(=O)Cl.N#Cc1ccc(S(=O)(=O)C2CCNCC2)cc1>>CC(=O)N1CCC(S(=O)(=O)c2ccc(C#N)cc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20090181942A1,CCOC(=O)/C(Cl)=C/C(=O)[O-].COc1ccc(CNc2ccc(Cl)cc2C(O)c2cccc(OC)c2Cl)c(OC)c1>>CCOC(=O)/C=C/C(=O)N(Cc1ccc(OC)cc1OC)c1ccc(Cl)cc1C(O)c1cccc(OC)c1Cl,,ClCCl,ClCCl,O=C([O-])O.[Na+],,val
US20090170907A1,CC(=O)Cl.N#Cc1ccc(N(Cc2noc(CN)n2)CC(F)(F)F)cc1C(F)(F)F>>CC(=O)NCc1nc(CN(CC(F)(F)F)c2ccc(C#N)c(C(F)(F)F)c2)no1,,ClCCl,,,,val
US20100298298A1,COc1ccc(Cn2c(=O)c3cc(OCc4ccccc4)ccc3n(C3CCN(C(C)=O)CC3)c2=O)cc1OC>>COc1ccc(Cn2c(=O)c3cc(O)ccc3n(C3CCN(C(C)=O)CC3)c2=O)cc1OC,[Pd],CCO,,O=C[O-].[NH4+],,val
US20130109670A1,CC(C)(C)OC(=O)N1CC(Nc2nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc(N3CCOCC3)n2)C1>>O=C(Nc1ccncc1)Nc1ccc(-c2nc(NC3CNC3)nc(N3CCOCC3)n2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090130076A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1cc(-c2cccc(Cl)c2)c2nc(N)oc2c1>>COC(=O)c1cc(-c2cccc(Cl)c2)c2nc(NC(=O)OC(C)(C)C)oc2c1,CN(C)c1ccncc1,ClCCl,,,,val
US04997836,CCOC(=O)C1CNCCN1.COc1cc2c(cc1OC)CCCC(C(=O)Cl)=C2>>CCOC(=O)C1CN(C(=O)C2=Cc3cc(OC)c(OC)cc3CCC2)CCN1,,ClCCl,,CCN(CC)CC,Cl,val
US20080085890A1,CC(C)I.O=C1NC(=O)c2ccc(Br)cc2/C1=C/NCc1ccc(O)c(O)c1>>CC(C)Oc1ccc(CN/C=C2\C(=O)NC(=O)c3ccc(Br)cc32)cc1O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140163000A1,CN(C)Cc1ccc(O)cn1.O=[N+]([O-])c1cnccc1Cl>>CN(C)Cc1ccc(Oc2ccncc2[N+](=O)[O-])cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020193398A1,N#Cc1cc(Cl)ccc1Cl.c1nc[nH]n1>>N#Cc1cc(Cl)ccc1-n1cncn1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US08080566B1,Brc1ccc(NN=C2CCCCC2)cc1>>Brc1ccc2[nH]c3c(c2c1)CCCC3,,CCOC(C)=O,,Cl,[Na+].[OH-],val
US05646125,CC(=O)OC[C@H]1O[C@@H](n2c(Cl)nc3ccc(N)cc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O>>Nc1ccc2nc(Cl)n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2c1,,CO,N,,,val
US20060178438A1,CCCCCOCCN(C)C(C)SC.Nc1ccc2c(c1)[C@@H](NC(=O)c1ccc(-c3ccccc3)cc1)[C@H](O)C2>>CCCCCOCCN(C)C(C)=Nc1ccc2c(c1)[C@@H](NC(=O)C1(c3ccccc3)C=CC=CC1)[C@H](O)C2,,c1ccncc1,,O=S(=O)(O)C(F)(F)F,,val
US20040014773A1,C[Si](C)(C)I.O=c1[nH]c(NCc2ccc(Cl)c(Cl)c2)nc2ncn(CCCCCO)c12>>O=c1[nH]c(NCc2ccc(Cl)c(Cl)c2)nc2ncn(CCCCCI)c12,,ClC(Cl)Cl,,,,val
US20150344459A1,CCC(C)n1cc(C)c2c(C(=O)NCc3c(C)[nH]c(C)cc3=O)cc(-c3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)nc3)cc21>>CCC(C)n1cc(C)c2c(C(=O)NCc3c(C)[nH]c(C)cc3=O)cc(-c3ccc(N4CCNCC4)nc3)cc21,Cl,Cl,,O=C([O-])O.[Na+],,val
US20070117796A1,O=C(C1CCCO1)N1CCNCC1.O=C(Cl)OCCCCl>>O=C(OCCCCl)N1CCN(C(=O)C2CCCO2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05310722,COC(=O)COC(=S)c1cc([N+](=O)[O-])c(F)cc1Cl>>COC(=O)COC(=S)c1cc(N)c(F)cc1Cl,[Ni],C1CCOC1,,[H][H],,val
US20090137595A1,Nc1cc(O)ccc1Br.O=C(Nc1cn2nc(I)ccc2n1)C1CC1>>Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)ccc1Br,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06759509B1,CC(=O)O.CC(CNC(=O)OCc1ccccc1)N(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C.CCO>>CC(=O)O.CC(=O)O.CC(N)CN(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C,[Ni],CCO,,,,val
US20130225552A1,CC(C)(C)OC(=O)N[C@@H]1C[C@H](N)C1.Clc1nc2ccccc2s1>>CC(C)(C)OC(=O)N[C@@H]1C[C@H](Nc2nc3ccccc3s2)C1,,CS(C)=O,O,CCN(C(C)C)C(C)C,,val
US20090124625A1,O=S(Cl)Cl.OCc1cn2ccccc2n1>>ClCc1cn2ccccc2n1,,ClCCl,,,,val
US20110065681A1,CC(C)(C)[Si](C)(C)OC[C@H](O)c1ccc(C(F)F)nc1.CS(=O)(=O)Cl>>CC(C)(C)[Si](C)(C)OC[C@H](OS(C)(=O)=O)c1ccc(C(F)F)nc1,,ClCCl,,CCN(CC)CC,O,val
US20110028492A1,CC(C)(C)OC(=O)N(C1CCOC1)[C@@H]1CC[C@@H](N)CC1.Fc1cc(-c2nc(NCC3CCOCC3)ccc2Cl)c(Cl)cn1>>Clc1cnc(N[C@@H]2CC[C@@H](NC3CCOC3)CC2)cc1-c1nc(NCC2CCOCC2)ccc1Cl,,CCOC(C)=O,CN1CCCC1=O,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20110112065A1,CC(C)(C)CN.CS(=O)(=O)c1cc(F)c2c(c1)OC(CBr)OC2>>CC(C)(C)CNCC1OCc2c(F)cc(S(C)(=O)=O)cc2O1,,CCO,,,,val
US06936602B1,C1CCOC1.CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCN3Cc2nnn[nH]2)cc1.CCN(CC)CC.CN(C)C=O>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CCN3Cc2nnn[nH]2)cc1,,O,,O=S(Cl)Cl,,val
US20100056577A1,Cc1ccc(S(=O)(=O)OC2CN=C(c3cccnc3F)C2(F)F)cc1>>Cc1ccc(S(=O)(=O)OC2CNC(c3cccnc3F)C2(F)F)cc1,,C1CCOC1,,CO,[BH4-].[Na+],val
US20090181989A1,CSc1nc(-c2ccc(C)cc2C)c2nc(Cl)n(C3CCCCO3)c2n1>>CSc1nc(-c2ccc(C)cc2C)c2nc(Cl)[nH]c2n1,,CO,,,,val
US20020035137A1,COC(=O)c1ccc([N+](=O)[O-])cc1Nc1cccc2ccc(O[Si](C)(C)C(C)(C)C)cc12>>COC(=O)c1ccc(N)cc1Nc1cccc2ccc(O[Si](C)(C)C(C)(C)C)cc12,[Fe],CC(C)O,CCOC(C)=O,O,[Cl-].[NH4+],val
US20090181967A1,CC(C)(C)OC(=O)N1CCOCC1COC(=O)N1CCN(c2ccc(F)cc2F)CC1>>O=C(OCC1COCCN1)N1CCN(c2ccc(F)cc2F)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150252022A1,O=C(NCc1ccccc1)N1CCC(Cn2ccc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CC1>>O=C(NCc1ccccc1)N1CCC(CN2CCc3cc(-c4cn[nH]c4)ccc32)CC1,,CCO,CCO,Cl,[BH3-]C#N.[Na+],val
US07199125B2,O=C(O)[C@@H]1C[C@@H](O)CN1.O=C=Nc1cc(Cl)cc(Cl)c1>>O=C(O)[C@@H]1C[C@@H](O)CN1C(=O)Nc1cc(Cl)cc(Cl)c1,,C1CCOC1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20130303518A1,Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCCC1)CCC2.O=C1Cc2c(cccc2-c2cccc(F)c2F)N1>>Cc1c(/C=C2\C(=O)Nc3cccc(-c4cccc(F)c4F)c32)[nH]c2c1C(=O)N(CCN1CCCC1)CCC2,,CO,,C1CCNCC1,,val
US04104467,CCOC(=O)CCN=c1sc2ccccc2s1>>O=C(O)CCN=c1sc2ccccc2s1,,CCO,O,[Na+].[OH-],,val
US20060106029A1,Clc1cccc(Cl)n1.Nc1nccs1>>Clc1cccc(Nc2nccs2)n1,,CCOC(C)=O,,Cc1ccccc1,O=C([O-])[O-].[Cs+].[Cs+],val
US20110046133A1,Nc1ccc([N+](=O)[O-])cc1N.O=Cc1c(Cl)cccc1Cl>>Nc1ccc2nc(-c3c(Cl)cccc3Cl)[nH]c2c1,,CS(C)=O,,[Cl-].[NH4+],,val
US20160176858A1,C[C@@H]1CC[C@@H](C(N)=O)CN1C(=O)c1ccccc1-n1nccn1.O=C(CBr)c1ccccc1>>C[C@@H]1CC[C@@H](c2nc(-c3ccccc3)co2)CN1C(=O)c1ccccc1-n1nccn1,,CN(C)C=O,,,,val
US20090275602A1,CC(C)(C)OC(=O)NC(C(CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H](F)c1ccccc1>>CC(C)(C)OC(=O)NC(C(CO)O[Si](C)(C)C(C)(C)C)[C@H](F)c1ccccc1,,c1ccncc1,,C1CCOC1,,val
US20100168469A1,CC(C)(C)C1=CC(=CNCCCNC=C2C=C(C(C)(C)C)C=C(C(C)(C)C)C2=O)C(=O)C(C(C)(C)C)=C1.O=CC(=O)O>>CC(C)(C)C1=CC(=CNCCCNC=C2C=C(C(C)(C)C)C=C(C(C)(C)C)C2=O)C(=O)C(C(C)(C)C)=C1.O=CC(=O)O,[Pd],CO,,CCN(CC)CC,O,val
US20140038941A1,CC(C)(C)c1nc2cc(C(=O)NN)ccn2c1CC1CCCCC1.O=C(Cl)c1ccccc1>>CC(C)(C)c1nc2cc(C(=O)NNC(=O)c3ccccc3)ccn2c1CC1CCCCC1,,ClCCl,,c1ccncc1,,val
US20120040985A1,COc1cc(C(C)(C)c2cnc(S)n2-c2ccc(F)cc2)ccc1Cl.N#CCOc1cc(F)c(CO)c(F)c1>>COc1cc(C(C)(C)c2cnc(SCc3c(F)cc(OCC#N)cc3F)n2-c2ccc(F)cc2)ccc1Cl,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05376677,COC=C(C(=O)OC)c1csc2ccc(C)cc12.O=C1CCC(=O)N1Br>>COC=C(C(=O)OC)c1csc2ccc(CBr)cc12,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20100216788A1,COC(=O)c1cc(Oc2ccc(N)cc2Cl)cc(C(F)(F)F)c1.O=C(OCCOCCn1ccc2ncnc(Cl)c21)c1ccccc1>>COC(=O)c1cc(Oc2ccc(Nc3ncnc4ccn(CCOCCOC(=O)c5ccccc5)c34)cc2Cl)cc(C(F)(F)F)c1,,CC(C)O,,,,val
US20100331293A1,O=[N+]([O-])c1cc(N2CCS(=O)(=O)CC2)cnc1N1CCOCC1>>Nc1cc(N2CCS(=O)(=O)CC2)cnc1N1CCOCC1,[Pd],CO,,,,val
US20100216820A1,Cc1ccccc1NC(=O)c1ccsc1N.O=C(Cl)CCl>>Cc1ccccc1NC(=O)c1ccsc1NC(=O)CCl,,ClCCl,,CCN(CC)CC,Cl,val
US20150141406A1,COc1nccc2c1c(-c1ccc(S(N)(=O)=O)cc1)nn2C1CCCC1.O=C1CCC(=O)N1Br>>COc1ncc(Br)c2c1c(-c1ccc(S(N)(=O)=O)cc1)nn2C1CCCC1,,CN(C)C=O,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20050043315A1,CC(=O)Cl.CC(C)n1nc(-c2cnc(N)nc2-c2ccccc2)ccc1=O>>CC(=O)Nc1ncc(-c2ccc(=O)n(C(C)C)n2)c(-c2ccccc2)n1,,c1ccncc1,,,,val
US20090258855A1,Cc1ccc2nnc(S)n2n1.Cn1cc(-c2cnc3[nH]ccc3c2)cn1>>Cc1ccc2nnc(Sc3c[nH]c4ncc(-c5cnn(C)c5)cc34)n2n1,,CN(C)C=O,,II,,val
US05260307,CN1CC(=O)Nc2ccccc2C1=O.Cc1ccc(S(=O)(=O)OC[C@@H]2COC(C)(C)N2C(=O)OC(C)(C)C)cc1>>CN1CC(=O)N(C[C@@H]2COC(C)(C)N2C(=O)OC(C)(C)C)c2ccccc2C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20140051679A1,CCc1cccc(CC)c1N=C=O.CN1CCOC(c2ccc(-c3n[nH]c4ccc(N)cc34)cc2)C1.O=C(O)C(F)(F)F>>CCc1cccc(CC)c1NC(=O)Nc1ccc2[nH]nc(-c3ccc(C4CN(C)CCO4)cc3)c2c1.O=C(O)C(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20160212997A1,Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1SC1CCNC1=O.O=C(OO)c1cccc(Cl)c1>>Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1S(=O)C1CCNC1=O,,ClCCl,,O,,val
US20120065233A1,Cc1c2c(cc3[nH]c(-c4c(NC(C)Cc5c(F)c(F)cc(F)c5F)cc[nH]c4=O)nc13)C(=O)N(CCN(C)C)C2=O>>Cc1c2c(cc3[nH]c(-c4c(NC(C)Cc5c(F)c(F)cc(F)c5F)cc[nH]c4=O)nc13)CN(CCN(C)C)C2=O,[Zn],CC(=O)O,,,,val
US20110178053A1,Brc1cnc2[nH]c3cnc(-c4cccnc4)cc3c2c1.CC(=O)Cl>>CC(=O)n1c2cnc(-c3cccnc3)cc2c2cc(Br)cnc21,,CN(C)C=O,O,[H-].[Na+],,val
US20100240708A1,CCOC(=O)[C@@H]1CCC[C@@H]1N.O=S(=O)(Cl)c1ccc(Cl)cc1>>CCOC(=O)[C@@H]1CCC[C@@H]1NS(=O)(=O)c1ccc(Cl)cc1,,C1CCOC1,,CCN(CC)CC,CCOCC,val
US20160102073A1,COC(=O)c1c(OC)ccnc1O[C@@H]1CC[C@@H](C)N(C(=O)c2cccc(F)c2-n2nccn2)C1>>COc1ccnc(O[C@@H]2CC[C@@H](C)N(C(=O)c3cccc(F)c3-n3nccn3)C2)c1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080319057A1,NCCc1cccc(OCc2cccc(F)c2)c1.O=Cc1ccco1>>Fc1cccc(COc2cccc(CCNCc3ccco3)c2)c1,,CCO,,[BH4-].[Na+],,val
US05679746,FCCCCCCCBr.Fc1ccc(C2CC[SiH](Cl)CC2)cc1F>>FCCCCCCC[SiH]1CCC(c2ccc(F)c(F)c2)CC1,,C1CCOC1,,[Mg],,val
US20100004264A1,CC(C)(C)OC(=O)N1CCN(C(=O)Cc2ccc(F)cc2F)CC1>>CC(C)(C)OC(=O)N1CCN(CCc2ccc(F)cc2F)CC1,,C1CCOC1,,,,val
US20150133675A1,COC(C(=O)O)c1ccc(-c2nnc(C)o2)cc1.COCCN(CCOC)S(F)(F)F>>COC(C(=O)N(C)OC)c1ccc(-c2nnc(C)o2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100130556A1,COC(=O)CP(=O)(OC)OC.O=Cc1ccc(Cl)c([N+](=O)[O-])c1>>COC(=O)C=Cc1ccc(Cl)c([N+](=O)[O-])c1,,C1CCOC1,,O,[H-].[Na+],val
US20070161662A1,CCOC=C(C#N)C#N.CCc1ccccc1NN>>CCc1ccccc1-n1ncc(C#N)c1N,,CCO,ClCCl,CCN(CC)CC,Cl,val
US20100130738A1,CC(C)(C)[Si](C)(C)OCc1cccn2nc(C(F)(F)F)nc12.ICCI>>CC(C)(C)[Si](C)(C)OCc1ccc(I)n2nc(C(F)(F)F)nc12,,C1CCOC1,CCCCCC,[Li]CCCC,O=C([O-])O.[Na+],val
US20060276508A1,CCOC(=O)c1ccc(I)c(OCC)c1.CCOc1cc(C=O)ccc1I>>CCOc1cc(C=O)ccc1C1CC1,O=[Mn]=O,,,CC(C)C[AlH]CC(C)C,,val
US20110312935A1,CCOC(=O)c1ccc(N)c(N)c1.S=C=Nc1c(Cl)cccc1Cl>>CCOC(=O)c1ccc2[nH]c(Nc3c(Cl)cccc3Cl)nc2c1,,CN(C)C=O,,CC(C)N=C=NC(C)C,,val
US20090264426A1,CN(C)CCO.O=[N+]([O-])c1ccc2nc(Cl)ccc2c1>>CN(C)CCOc1ccc2cc([N+](=O)[O-])ccc2n1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04956462,COC(=O)C#CC(=O)OC.Nc1n[nH]c(CO)n1>>COC(=O)c1cc(O)n2nc(CO)nc2n1,,CO,,,,val
US20080021059A1,CCN.CN1CCC(N(C)c2cc(-c3cccnc3)cc3nc(N)nn23)CC1.Cc1ccc(S(=O)(=O)N=C=O)cc1>>CCNC(=O)Nc1nc2cc(-c3cccnc3)cc(N(C)C3CCN(C)CC3)n2n1,,C1CCOC1,CN(C)C=O,,,val
US20090298830A1,Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1.O=C(Cl)CCl>>O=C(CCl)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1,,C1CCOC1,,,,val
US20090005353A1,BrCC1CCCO1.CC(C)(C)N1C(=O)C(NCCCCc2ccccc2)=C(c2ccccc2)S1(=O)=O>>O=C1C(NCCCCc2ccccc2)=C(c2ccccc2)S(=O)(=O)N1CC1CCCO1,,O=C(O)C(F)(F)F,,O=C([O-])[O-].[K+].[K+],,val
US20040224970A1,COc1ccc(-c2cc3c(n2-c2ccccc2Cl)CCNC3)cc1.O=C(Cl)c1cccc(Cl)c1>>COc1ccc(-c2cc3c(n2-c2ccccc2Cl)CCN(C(=O)c2cccc(Cl)c2)C3)cc1,,ClCCl,,,,val
US20050261327A1,CS(=O)(=O)Cl.OCC1CCC2(CC1)OC=Cc1ccccc12>>CS(=O)(=O)OCC1CCC2(CC1)OC=Cc1ccccc12,,ClCCl,,CCN(CC)CC,,val
US05714498,C(=Cc1ccncc1)c1ccccc1.ClCc1nc2ccccc2[nH]1>>C1=C(/C=C/c2ccccc2)CCN(Cc2nc3ccccc3[nH]2)C1,,CCO,CN(C)C=O,[BH4-].[Na+],,val
US20120238545A1,CCOC(=O)c1nn(-c2ccccc2)c(Br)c1C=O>>CCOC(=O)c1nn(-c2ccccc2)c(Br)c1CO,,CCO,,C1CCOC1,[BH4-].[Na+],val
US05053072,CCOC(=O)c1nc(OC)cc(OC)n1>>COc1cc(OC)nc(C(=O)O)n1,,CCO,O,[Na+].[OH-],,val
US20110257151A1,CC1(C)Cc2cc(C(=O)O)ccc2NC1c1ccc(F)c(N2CCOCC2)c1.NS(=O)(=O)C1CC1>>CC1(C)Cc2cc(C(=O)NS(=O)(=O)C3CC3)ccc2NC1c1ccc(F)c(N2CCOCC2)c1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20010051614A1,BrCc1ccccc1.COC(=O)c1cc(OC)nc(OC)c1NS(=O)(=O)c1ccc(OC)cc1>>COC(=O)c1cc(OC)nc(OC)c1N(Cc1ccccc1)S(=O)(=O)c1ccc(OC)cc1,,CN(C)C=O,O,[H-].[Na+],,val
US20040224959A1,CCOC(=O)c1cccc(N2CCN(CCC(c3ccccc3)c3ccccc3)CC2)c1>>O=C(O)c1cccc(N2CCN(CCC(c3ccccc3)c3ccccc3)CC2)c1,,CO,,C1CCOC1,[Na+].[OH-],val
US04734410,CC(C)(C)OC(=O)CN1C[C@H](c2ccccc2)CC[C@H](N=[N+]=[N-])C1=O>>CC(C)(C)OC(=O)CN1C[C@H](c2ccccc2)CC[C@H](N)C1=O,[Pd],,,,,val
US20110039840A1,BrCCc1c[nH]c2ccccc12.COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCN(C(=O)OC(C)(C)C)CC1)O2>>COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCN(CCc3c[nH]c4ccccc34)CC1)O2,,ClCCl,,,,val
US20110144334A1,COC(=O)Cl.Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)NC1CCCO1>>COC(=O)N(C(=O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1C)C1CCCO1,,C1CCOC1,O,[H-].[Na+],,val
US20150080393A1,CS(=O)(=O)c1ccc(C=O)c(-c2ccccc2)c1.C[Si](C)(C)C(F)(F)F>>CS(=O)(=O)c1ccc(C(O)C(F)(F)F)c(-c2ccccc2)c1,,C1CCOC1,,Cl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20110118245A1,COCCOc1cc(NC(=O)Oc2ccccc2)ccc1C(F)(F)F.COc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC>>COCCOc1cc(NC(=O)Nc2cccc(Oc3ncnc4cc(OC)c(OC)cc34)c2)ccc1C(F)(F)F,CN(C)c1ccncc1,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20060025400A1,COC(=O)c1ccc([C@H]2CCCCN2C(=O)CC2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)cc1>>Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCCC2c2ccc(CO)cc2)cc1,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20040166125A1,CC(C)=CCn1c(Cl)nc2c1c(=O)[nH]c(=O)n2C.O=C(CBr)c1ccccc1[N+](=O)[O-]>>CC(C)=CCn1c(Cl)nc2c1c(=O)n(CC(=O)c1ccccc1[N+](=O)[O-])c(=O)n2C,,CN(C)C=O,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20020099055A1,COC(=O)/C=C/C(=O)CC(C)C.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>COC(=O)c1c[nH]cc1C(=O)CC(C)C,,CCOCC,CS(C)=O,[H-].[Na+],[Cl-].[NH4+],val
US20050131019A1,CC(C)(C)OC(=O)N1C(COc2ccc(N)c3ccccc23)CCC1C(=O)N1CCCC1C#N.CS(=O)(=O)Cl>>CS(=O)(=O)Nc1ccc(OC[C@H]2CC[C@@H](C(=O)N3CCC[C@H]3C#N)N2)c2ccccc12,,ClCCl,,c1ccncc1,,val
US20130345123A1,C=CC(C)(C)C(NC(=O)OC(C)(C)C)C(=O)O.C=CCNc1ccccc1>>C=CCN(C(=O)C(NC(=O)OC(C)(C)C)C(C)(C)C=C)c1ccccc1,,CCOC(C)=O,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20100240620A1,CCCC(=O)OCC.Cc1csc(C)n1>>CCCC(=O)Cc1nc(C)cs1,,C1CCOC1,,[Li]CCCC,,val
US20160152605A1,COc1cc(C)c2c(ccn2C(=O)OC(C)(C)C)c1C=O.C[Si](C)(C)C(F)(F)F>>COc1cc(C)c2c(ccn2C(=O)OC(C)(C)C)c1C(O)C(F)(F)F,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04783528,CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.O=C(Cl)CCl>>CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)CCl)CC[C@]4(C)[C@H]3CC[C@]12C,,c1ccccc1,,CCN(CC)CC,,val
US20100168110A1,COc1c(C)ccc2c1CC(Br)C2=O.O=[N+]([O-])c1ccc(O)cc1>>COc1c(C)ccc2c1CC(Oc1ccc([N+](=O)[O-])cc1)C2=O,,CN(C)C=O,,O,[Na],val
US04323691,CCOC(=O)C(C)Oc1ccc(C(=O)c2ccc(OC)cc2)c(Cl)c1Cl>>CC(Oc1ccc(C(=O)c2ccc(O)cc2)c(Cl)c1Cl)C(=O)O,,O,,Br,,val
US20090029947A1,CCCCCCCCc1ccc(C2CC(O)CO2)cc1>>CCCCCCCCc1ccc(C2CC(=O)CO2)cc1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20140213599A1,O=Cc1ccc(F)c(F)c1>>OCc1ccc(F)c(F)c1,,CO,O,[BH4-].[Na+],,val
US05968982,CCOC(=O)C(Cl)(Cl)CCCCCCCCCCSc1ccc(Cl)cc1.OO>>CCOC(=O)C(Cl)(Cl)CCCCCCCCCCS(=O)c1ccc(Cl)cc1,,CC(=O)O,,,,val
US20090181942A1,COc1ccc(C=O)c(OC)c1.Nc1ccc(Cl)cc1C(O)c1cccc2c1OCCO2>>COc1ccc(CNc2ccc(Cl)cc2C(O)c2cccc3c2OCCO3)c(OC)c1,,CC(=O)O,,[BH4-].[Na+],,val
US20060167266A1,CSc1nsc(-c2cccc(Cl)c2)n1.O=C(OO)c1cccc(Cl)c1>>CS(=O)(=O)c1nsc(-c2cccc(Cl)c2)n1,,ClC(Cl)Cl,,O=S([O-])[O-].[Na+].[Na+],,val
US20070259910A1,CN(C)c1ccc(F)c([N+](=O)[O-])c1>>CN(C)c1ccc(F)c(N)c1,[Pd],CO,,[H][H],,val
US20160060197A1,CC(c1cccc(C(=O)C2CC2)c1OCc1ccccc1)C1CC1.C[Mg]Br>>CC(c1cccc(C(C)(O)C2CC2)c1OCc1ccccc1)C1CC1,,C1CCOC1,,,,val
US20080167287A1,CC(C)(C)OC(=O)Cn1ccc(-c2cnc(N)nc2)n1.O=C1CCC(=O)N1C(O)C(Cl)C1(c2ccc3ncccc3c2)CC1>>CC(C)(C)OC(=O)Cn1ccc(-c2cnc3ncc(C4(c5ccc6ncccc6c5)CC4)n3c2)n1,,CCO,,,,val
US20120129832A1,CC(C)(C)OC(=O)NCC(=O)O.CCC(Oc1ccc(-c2noc(C(C)C)n2)cc1)c1nc(-c2ccc(C(=O)OC)c(F)c2)no1.CN(C)C=O.CN(C)c1ccncc1>>CCC(Oc1ccc(-c2noc(C(C)C)n2)cc1)c1nc(-c2ccc(C(=O)N[C@H](C)COC(=O)CNC(=O)OC(C)(C)C)c(F)c2)no1,CN(C)c1ccncc1,O,,CCN=C=NCCCN(C)C,,val
US20160159774A1,C=CC(=O)N1CCC[C@@H](Nc2nc(Nc3ccc4c(c3)CNC4)ncc2F)C1.CC(C)=O>>C=CC(=O)N1CCC[C@@H](Nc2nc(Nc3ccc4c(c3)CN(C(C)C)C4)ncc2F)C1,,CO,O,[BH3-]C#N.[Na+],,val
US20030045581A1,Cc1ccc(N=C=O)c(C)c1.NNC(=O)c1ccc(Cl)cc1>>Cc1ccc(NC(=O)NNC(=O)c2ccc(Cl)cc2)c(C)c1,,ClCCl,,,,val
US20050182045A1,Cc1nc2ccc(Br)cc2c(=O)n1-c1ccc(OCCCN2CCCCC2)cc1.OB(O)c1ccccc1>>Cc1nc2ccc(-c3ccccc3)cc2c(=O)n1-c1ccc(OCCCN2CCCCC2)cc1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US05705456,CC(CCl)(CCl)C(=O)O.O=C(Cl)C(=O)Cl>>CC(CCl)(CCl)C(=O)Cl,CN(C)C=O,ClCCl,,,,val
US20110275797A1,CC(=O)OC(C)=O.O=C(Nc1cc(-c2ccccc2)ccc1C(=O)O)c1cc(OC2CCNCC2)ccc1O>>CC(=O)N1CCC(Oc2ccc(O)c(C(=O)Nc3cc(-c4ccccc4)ccc3C(=O)O)c2)CC1,,c1ccncc1,,Cl,ClCCl,val
US20040170909A1,O=C(O)c1ccccc1-c1ccccc1C(=O)O>>O=C(O)c1cccc2c1-c1ccccc1C2=O,,O=S(=O)(O)O,,,,val
US20070093521A1,CCOc1cc(C=O)cc(OCC)c1-n1cccc1.COC(=O)COc1ccc2oc(NC3CCNCC3)nc2c1>>CCOc1cc(CN2CCC(Nc3nc4cc(OCC(=O)OC)ccc4o3)CC2)cc(OCC)c1-n1cccc1,,CC(=O)O,CCO,CCN(C(C)C)C(C)C,[BH3-]C#N.[Na+],val
US06479668B1,C1=CCN(Cc2ccccc2)C1.CC(C)=O.Sc1ccccc1>>OC1CN(Cc2ccccc2)CC1Sc1ccccc1,,CC(C)=O,,O,O=S(=O)(O)O,val
US20100261679A1,CN1CCN(c2ccccc2[N+](=O)[O-])CC1>>CN1CCN(c2ccccc2N)CC1,[Pd],CCO,,,,val
US04568749,C#C.O=Cc1ccc(F)cc1>>C#CC(O)c1ccc(F)cc1,,C1CCOC1,,[Li]CCCC,,val
US20030136944A1,CCC[C@@H]1CC[C@@H](c2ccc3cc(O)ccc3c2)CC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCC[C@@H]1CC[C@@H](c2ccc3cc(OS(=O)(=O)C(F)(F)F)ccc3c2)CC1,,ClCCl,,O,c1ccncc1,val
US20120184531A1,CC(C)(C)OC(=O)N1CCc2oc3c(Cl)cc(Sc4ccccc4)cc3c2C1.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)N1CCc2oc3c(Cl)cc(S(=O)c4ccccc4)cc3c2C1,,ClCCl,,,,val
US20070078155A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1nccc2ccc(Cl)nc12>>O=S(=O)(Oc1nccc2ccc(Cl)nc12)C(F)(F)F,,c1ccncc1,,,,val
US20060235033A1,COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.C[C@@H](N)c1cccc(Br)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)N[C@H](C)c4cccc(Br)c4)c(C)c3C)c2cc1OC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20100093748A1,CC(C)(C)OC(=O)NC1(C(=O)Nc2ccccc2O)CCN(C(=O)OC(C)(C)C)CC1>>CC(C)(C)OC(=O)NC1(c2nc3ccccc3o2)CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110301142A1,CCCCC(CC)COC(=O)CCS.Cc1noc(-c2ccc(Br)cc2)c1NC(=O)O[C@H](C)c1ccccc1F>>CCCCC(CC)COC(=O)CCSc1ccc(-c2onc(C)c2NC(=O)O[C@H](C)c2ccccc2F)cc1,,C1COCCO1,,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,CCN(C(C)C)C(C)C,val
US20080306170A1,CC(C)=O.Cc1ccc(CC#N)cc1>>CC(C)=C(C#N)c1ccc(C)cc1,,CO,,[K+].[OH-],,val
US20060276496A1,CCOC(=O)Cl.CN(C)CCNC(=O)c1csc(NC(=O)c2ccc3[nH]c4c(c3c2)CC(CN)NC4=O)n1>>CCOC(=O)NCC1Cc2c([nH]c3ccc(C(=O)Nc4nc(C(=O)NCCN(C)C)cs4)cc23)C(=O)N1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20090130117A1,COCCCn1nnnc1-c1cc(-c2cccc(C(=O)OC)c2)c(OCc2ccccc2)cc1OCc1ccccc1>>COCCCn1nnnc1-c1cc(-c2cccc(C(=O)O)c2)c(OCc2ccccc2)cc1OCc1ccccc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US07074801B1,ClCCCBr.Sc1cccs1>>ClCCCSc1cccs1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06239131B1,CC(C)(C)C(=O)CN1C(=O)C(N)CN(c2ccccc2)c2ccccc21.O=C(O)c1cccc(C(=O)OCc2ccccc2)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)OCc3ccccc3)c2)CN(c2ccccc2)c2ccccc21,,C1COCCO1,,CCN(CC)CC,,val
US05405873,CC(C)(C)C#CC#CCBr.NCCN>>CC(C)(C)C#CC#CCNCCN,,CCO,,,,val
US04866091,CCOC(=O)C(C(=O)OCC)C(=O)c1cc(Oc2ccc(F)cc2F)c([N+](=O)[O-])cc1C>>CC(=O)c1cc(Oc2ccc(F)cc2F)c([N+](=O)[O-])cc1C,,CC(=O)O,O,O=S(=O)(O)O,[Na+].[OH-],val
US20060128759A1,CCOC(=O)c1ccncc1.N#CCc1ccc(F)cc1>>N#CC(=C(O)c1ccncc1)c1ccc(F)cc1,,CCO,,C,C[O-].[Na+],val
US04816452,BrCC1CCCCC1.CCOC(=O)/C(=N\O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>CCOC(=O)/C(=N\OCC1CCCCC1)c1csc(N)n1,,O=CO,,Cl,,val
US20120122931A1,COc1ccc(CC(=O)c2ccccc2)c(NC(=O)OC(C)(C)C)c1>>COc1ccc2cc(-c3ccccc3)[nH]c2c1,,O=C(O)C(F)(F)F,,ClCCl,,val
US20100249229A1,CCC1C=C[C@@H]2[C@H]1C[C@]2(CN)CC(=O)O>>CCC1C=C[C@@H]2[C@H]1C[C@]2(CN)CC(=O)O,,ClCCl,,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US20030220307A1,C#CCC[C@H](C)C1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C.CCC(=O)CC>>CCC(O)(C#CCC[C@H](C)C1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C)CC,,C1CCOC1,,[Li]CCCC,,val
US05064815,CCCCC1C(=O)OC(C(C)C(O)CCCNC(=N)N)C(C)C=C(C)CCCCC(O)CC(O)CC(O)CC(O)CC(O)C(O[C@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)C=C(C)C(O)CCCC(O)CCCC(O)CCC(C)C1O>>CCCCC1C(=O)OC(C(C)C(O)CCCNC(=N)N)C(C)C=C(C)CCCCC(O)CC(O)CC(O)CC(O)CC(O)C(O[C@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)C=C(C)C(O)CCCC(O)CCCC(O)CCC(C)C1O,,CC(=O)N(C)C,,CN1CCCC1=O,,val
US20080275066A1,Cc1nc2c(C(=O)O)sc(S(C)(=O)=O)c2c(=O)[nH]1.Nc1ccc(C2CCCCC2)cc1>>Cc1nc2c(C(=O)Nc3ccc(C4CCCCC4)cc3)sc(S(C)(=O)=O)c2c(=O)[nH]1,,CN(C)C=O,,O,O=C(n1ccnc1)n1ccnc1,val
US20150025054A1,CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(O)cc1.Fc1ccccc1CBr>>CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(OCc2ccccc2F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04791114,ClCc1nc2ccccc2[nH]1.Sc1ncccn1>>c1cnc(SCc2nc3ccccc3[nH]2)nc1,,CCO,O,[Na+].[OH-],,val
US20120065195A1,CC1(C)CC(=O)c2cc(Br)ccc2C1.OB(O)c1cncnc1>>CC1(C)CC(=O)c2cc(-c3cncnc3)ccc2C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20120183616A1,O=C1NC(=O)c2c(CCCCCCBr)cccc21.SC(c1ccccc1)(c1ccccc1)c1ccccc1>>O=C1NC(=O)c2c(CCCCCCSC(c3ccccc3)(c3ccccc3)c3ccccc3)cccc21,,CS(C)=O,,C1CCC2=NCCCN2CC1,,val
US20120172351A1,COC(=O)C[C@@H]1COc2cc(NCc3ccc(C)c(-c4ccc(OC)nc4)c3C)ccc21>>COc1ccc(-c2c(C)ccc(CNc3ccc4c(c3)OC[C@H]4CC(=O)O)c2C)cn1,,C1CCOC1,CO,[Na+].[OH-],,val
US20040043978A1,CC(=O)OC(c1nc2nc(C)c3c(n2n1)CCCC3)C1(Br)C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=CS[C@@H]21>>Cc1nc2nc(/C=C3/C(=O)N4C(C(=O)O)=CS[C@H]34)nn2c2c1CCCC2,[Pd],C1CCOC1,,CC#N,,val
US07544683B2,CC(C)N1CCN(C(=O)C2CCC(Oc3ccc(I)cc3)CC2)CC1.O=C1CCCCN1>>CC(C)N1CCN(C(=O)[C@@H]2CC[C@@H](Oc3ccc(N4CCCCC4=O)cc3)CC2)CC1,[Cu],CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120028961A1,BrP(Br)Br.CC(C)(C)C(=O)COc1ccc(CO)cc1>>CC(C)(C)C(=O)COc1ccc(CBr)cc1,,C1CCOC1,CCOC(C)=O,,,val
US20030229094A1,N#Cc1cccnc1N1CCNCC1.O=C(CCl)Nc1cccc([N+](=O)[O-])c1>>N#Cc1cccnc1N1CCN(CC(=O)Nc2cccc([N+](=O)[O-])c2)CC1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US20070281933A1,CC(=O)Nc1cccc(-c2cc(C(N)=O)c3[nH]nc(C4CCNCC4)c3c2)c1.Cc1nc(S(=O)(=O)Cl)cn1C>>CC(=O)Nc1cccc(-c2cc(C(N)=O)c3[nH]nc(C4CCN(S(=O)(=O)c5cn(C)c(C)n5)CC4)c3c2)c1,CN(C)c1ccncc1,,,CCN(C(C)C)C(C)C,,val
US20090053192A1,COc1cc(OC)c(C(=O)Cl)cc1OC.Nc1nc[nH]n1>>COc1cc(OC)c(C(=O)Nc2nc[nH]n2)cc1OC,,C1CCOC1,,,,val
US05114953,CNC(=O)[C@@H](N)Cc1c[nH]c2ccccc12.O=C(n1ccnc1)n1ccnc1>>N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCO,,ClCCl,,,,val
US20140288081A1,Nc1nc2cccc(F)c2s1>>Fc1cccc2ncsc12,,C1CCOC1,,CC(C)CCON=O,,val
US20040034005A1,CN1CCc2ccc(Cl)c3c4c(n(c23)CC1)CCCC4>>Clc1ccc2c3c1c1c(n3CCNCC2)CCCC1,,CC(Cl)Cl,,CC(Cl)OC(=O)Cl,,val
US20090105474A1,COc1cccc(/C=C/c2ccc(C(=O)OC(C)(C)C)c(Nc3ccc(F)cc3)c2)c1>>COc1cccc(/C=C/c2ccc(C(=O)O)c(Nc3ccc(F)cc3)c2)c1,,O=C(O)C(F)(F)F,,,,val
US20060211693A1,CCI.CCOCC.O=C(O)c1ccc(I)cc1O>>CCOC(=O)c1ccc(I)cc1OCC,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150266867A1,CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)N[C@@H]2C(=O)N(S(=O)(=O)O)[C@@H]2Cn2nccn2)cs1>>CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N(S(=O)(=O)O)[C@@H]1Cn1nccn1)c1csc(N)n1)C(=O)O,,O=CO,,,,val
US20050209166A1,O=C1CCC(=O)N1Br.OCc1cc(Br)ccc1Cl>>Clc1ccc(Br)cc1CBr,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06518283B1,COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C.O=C(Cl)c1c(Cl)cncc1Cl>>COC(=O)[C@H](Cc1ccc(OC(=O)c2c(Cl)cncc2Cl)cc1)NC(=O)OC(C)(C)C,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US05741797,COc1ccc(C(C)(C)O)cc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1.O=S(=O)(O)c1ccccc1>>COc1ccc(C(C)(C)O)cc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1.O=S(=O)(O)c1ccccc1,,CO,,,,val
US20140235660A1,COC(=O)/C=C/c1ccc(O)cc1.COc1ccc(C2=C(Br)c3ccc(OC)cc3S2=O)cc1>>COC(=O)/C=C/c1ccc(OC2=C(c3ccc(OC)cc3)S(=O)c3cc(OC)ccc32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05444152,C1CCCNCC1.CC(C)C[C@H](N)C(=O)OCc1ccccc1.O=C(n1ccnc1)n1ccnc1>>CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)OCc1ccccc1,,C1CCOC1,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100069349A1,CC(C)c1cc(N)[nH]n1.COC(OC)N(C)C>>CC(C)c1cc(/N=C/N(C)C)[nH]n1,,C1COCCO1,,,,val
US20080188528A1,COC(=O)c1cccn(Cc2ccc(Br)cc2)c1=O>>O=C(O)c1cccn(Cc2ccc(Br)cc2)c1=O,,CO,,[Na+].[OH-],,val
US20110301141A1,C1COCCN1.COc1c([N+](=O)[O-])ccc(C(=O)O)c1F>>COc1c([N+](=O)[O-])ccc(C(=O)N2CCOCC2)c1F,,ClCCl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160046596A1,CCc1nccc(C=O)c1OCOC>>CCc1nccc(C=O)c1O,,C1CCOC1,,Cl,O=C([O-])[O-].[K+].[K+],val
US20040147739A1,COc1ccc2[nH]c(=O)oc(=O)c2c1.N#CCCCBr>>COc1ccc2c(c1)c(=O)oc(=O)n2CCCC#N,,CC(=O)N(C)C,,[H-].[Na+],,val
US04404203,NC(=O)c1cc(-c2ccccc2)n[nH]c1=O>>N#Cc1cc(-c2ccccc2)n[nH]c1=O,,CC(=O)OC(C)=O,,,,val
US20120094968A1,CC1=C(C#N)[C@@H](c2ccc(C#N)cc2[N+](=O)[O-])NC(=O)N1c1cccc(C(F)(F)F)c1>>CC1=C(C#N)[C@@H](c2ccc(C#N)cc2N)NC(=O)N1c1cccc(C(F)(F)F)c1,[Pd],CCO,,,,val
US20150166558A1,CCOC(=O)CCCNc1cccc(C(N)Cn2c(=O)c3c(n(Cc4c(F)cccc4C(F)(F)F)c2=O)COC32CCN(Cc3ccc(C(F)(F)F)o3)CC2)c1>>NC(Cn1c(=O)c2c(n(Cc3c(F)cccc3C(F)(F)F)c1=O)COC21CCN(Cc2ccc(C(F)(F)F)o2)CC1)c1cccc(NCCCC(=O)O)c1,,CCO,,Cl,[Na+].[OH-],val
US20100010053A1,CC(C)Oc1ccc(-c2nc(-c3cccc4c(C=O)c[nH]c34)no2)cc1C#N.CNCC(=O)O>>CC(C)Oc1ccc(-c2nc(-c3cccc4c(CN(C)CC(=O)O)c[nH]c34)no2)cc1C#N,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US06169091A,Cc1csc2ncnc(Cl)c12.Nc1ccc(Oc2ccccc2)cc1>>Cc1csc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c12.Cl,,CC(C)O,,,,val
US20110046397A1,COC(OC)C1C[C@@H](Cc2ccc(-c3ccccc3)cc2)N(C(=O)OC(C)(C)C)C1=O>>CC(C)(C)OC(=O)N1CCCC1=O,,CC(C)=O,,O,,val
US20140039011A1,CC(C)[C@H]1COCCCCOc2ccc(cc2)C[C@@H](NS(=O)(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)N1>>CC(C)[C@H]1COCCCCOc2ccc(cc2)C[C@@H](NS(=O)(=O)N[C@@H](CCCCN)C(=O)O)C(=O)N1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20110034436A1,C1CCOC1.CC(C)(C)OC(=O)NC1(C(=O)O)CCCC1>>CC(C)(C)OC(=O)NC1(CO)CCOC1,,C1CCOC1,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20090069303A1,Nc1ccnc(Cc2n[nH]c(=O)c3ccccc23)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C=Nc1ccnc(Cc2n[nH]c(=O)c3ccccc23)c1,,ClCCl,,CCN(CC)CC,,val
US20110263647A1,COC(=O)c1ccc(Br)cc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COC(=S)c1ccc(Br)cc1,,Cc1ccccc1,,,,val
US20100179126A1,COC(=O)c1ccc(OC)cc1[N+](=O)[O-]>>COC(=O)c1ccc(OC)cc1N,,CO,,,,val
US20040023947A1,CC(C#N)c1cn(C(=O)OC(C)(C)C)c2ccccc12>>CC(C#N)c1c[nH]c2ccccc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US05686424,CC[C@H](C)[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)O.NCC12CC3CC(CC(C3)C1)C2>>CC[C@H](C)[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)NCC12CC3CC(CC(C3)C1)C2,,CC#N,,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20120245169A1,BrC(Br)(Br)Br.Cc1cccc2cc(CO)n(C(C)C)c(=O)c12>>Cc1cccc2cc(CBr)n(C(C)C)c(=O)c12,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070299092A1,C1COCCN1.COc1cc2ncnc(NC3=CC(=O)C(Cl)=CC3=O)c2cc1OC>>COc1cc2ncnc(NC3=CC(=O)C(N4CCOCC4)=CC3=O)c2cc1OC,,Cc1ccccc1,,,,val
US20160185769A1,CS(=O)(=O)c1ccc(F)c(Br)c1.Cc1cccc(C)c1O>>Cc1cccc(C)c1Oc1ccc(S(C)(=O)=O)cc1Br,,CS(C)=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US08138186B2,BrCCOCCBr.Oc1ccn(-c2ccc(Cl)c(Cl)c2)n1>>Clc1ccc(-n2ccc(OCCOCCBr)n2)cc1Cl,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US04032652,CC(=O)c1c(O)oc(=O)c(C(C)=O)c1O.Nc1ccc(F)cc1>>CC(=O)C1=C(O)C(=C(C)Nc2ccc(F)cc2)C(=O)OC1=O,,CO,,,,val
US20040097496A1,CC(C)(C)OC(=O)N(CC(=O)O)c1ccccc1>>CC(C)(C)OC(=O)N(CC(=O)O)C1CCCCC1,[Rh],CCO,,[H][H],,val
US05527818,Cc1c(Cl)ccc(O)c1Cl.O=S(=O)(Cl)c1nc[nH]n1>>Cc1c(Cl)ccc(OS(=O)(=O)c2nc[nH]n2)c1Cl,,C1CCOC1,,CCN(CC)CC,,val
US20120252777A1,CCOP(=O)(OCC)C(F)c1cccc(Br)c1.COC(=O)c1ccc(C=O)cc1>>COC(=O)c1ccc(/C=C(\F)c2cccc(Br)c2)cc1,,C1CCOC1,,O,CC(C)[N-]C(C)C.[Li+],val
US20050096337A1,CCOC(=O)c1cnc(-c2ccc(C(F)(F)F)cc2)nc1C1CC1>>O=C(O)c1cnc(-c2ccc(C(F)(F)F)cc2)nc1C1CC1,,CCO,O,Cl,[Na+].[OH-],val
US20090105474A1,CC(C)(C)OC(=O)c1ccc(CCc2ccccc2)cc1Nc1c(Cl)cccc1Cl>>O=C(O)c1ccc(CCc2ccccc2)cc1Nc1c(Cl)cccc1Cl,,O=C(O)C(F)(F)F,,,,val
US20140221333A1,COC(=O)c1ccc(C)nc1.Cl>>COC(=O)C1CCC(C)NC1.Cl,[Pd],CO,,[H][H],,val
US20150329497A1,COc1cc2nc(C3CC3)nc(Cl)c2cc1OC.COc1ccccc1NCCN>>COc1ccccc1NCCNc1c(OC)c(OC)cc2nc(C3CC3)ncc12,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20060211709A1,CC(C)(C)OC(=O)N1CCC[C@H](NC(=O)c2nc(Br)cnc2N)C1.OCc1cccc(B(O)O)c1>>CC(C)(C)OC(=O)N1CCC[C@H](NC(=O)c2nc(-c3cccc(CO)c3)cnc2N)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06225310B1,CC1(O)CSC(C)(O)CS1.N#CCS(N)(=O)=O>>Cc1csc(N)c1S(N)(=O)=O,,CCO,,CCN(CC)CC,,val
US20090105257A1,CC(C)N.CC(C)c1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@@H]2C[C@H]2C(=O)O)cc1>>CC(C)NC(=O)[C@@H]1C[C@H]1c1ccc(NCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C(C)C)cc1,,CN(C)C=O,ClCCl,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US04515793,BrBr.CC(=O)c1ccc(Cl)c(Cl)c1Cl>>O=C(CBr)c1ccc(Cl)c(Cl)c1Cl,,CCCCCC,,CC(=O)[O-].[Na+],,val
US20160200725A1,CCOC(=O)c1cnc(Cl)cc1NCc1ccc(OC)cc1OC>>CCOC(=O)c1cnc(Cl)cc1N,,O=C(O)C(F)(F)F,,,,val
US20130172328A1,O=[N+]([O-])c1ccc(Nc2nc3cccnc3n2CCO)cc1>>O=[N+]([O-])c1ccc(N2CCn3c2nc2cccnc23)cc1,,C1CCOC1,,CCN(CC)CC,O,val
US20150291557A1,COC(c1cncnc1)(c1ccc(Br)cc1F)C(C)(C)C.OB(O)c1ccc(OC(F)(F)F)cc1>>COC(c1cncnc1)(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1F)C(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20140011800A1,CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1CF>>N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1CF,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090163469A1,CC1(C(=O)Cl)CC1.COC=CC(C)=O>>COC=CC(=O)C=C(O)C1(C)CC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20040138273A1,CC(C)(C)OC(=O)NCCNc1ccc(CN2CCOCC2)c(-c2ccc(Cl)cc2Cl)c1>>NCCNc1ccc(CN2CCOCC2)c(-c2ccc(Cl)cc2Cl)c1,,C1COCCO1,CO,Cl,,val
US20030191124A1,CN1CC=C(c2c[nH]c3ccc(NS(=O)(=O)c4cccc5ccccc45)cc23)CC1>>CN1CCC(c2c[nH]c3ccc(NS(=O)(=O)c4cccc5ccccc45)cc23)CC1,[Pd],CCOCC,CO,[H][H],,val
US20030160212A1,CCCCCCBr.Oc1cc(F)ccc1F>>CCCCCCOc1cc(F)ccc1F,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US04877787,CC(C)(C)c1ccc(CBr)cc1.CC(C)(C)n1ncc(S)c(Br)c1=O>>CC(C)(C)c1ccc(CSc2cnn(C(C)(C)C)c(=O)c2Br)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US05466823,CC(=O)c1ccc(Cl)s1.CCOC(=O)C(F)F>>O=C(CC(=O)C(F)F)c1ccc(Cl)s1,,C1CCOC1,CCOCC,Cl,C[O-].[Na+],val
US20130116232A1,CC(C)(C)[Si](C)(C)Cl.C[C@@H](CO)N1CCC1>>C[C@@H](CO[Si](C)(C)C(C)(C)C)N1CCC1,CN(C)c1ccncc1,Cc1ccccc1,,,,val
US06348032B1,C1COCCN1.O=C(Cl)c1ccc2nc(C3CC3)n(Cc3ccccc3Cl)c2c1>>O=C(c1ccc2nc(C3CC3)n(Cc3ccccc3Cl)c2c1)C1CNCCO1,,ClCCl,,CO,Cl,val
US20150252030A1,COC(=O)COc1c(C(C)(C)C)cc(C)cc1C(C)(C)C.NN>>Cc1cc(C(C)(C)C)c(OCC(=O)NN)c(C(C)(C)C)c1,,CCO,,O,,val
US20070259864A1,CC(C)(C)OC(=O)N1CC2CN(CCN(CCOc3ccc(C#N)cc3)S(C)(=O)=O)CC(C1)O2>>CS(=O)(=O)N(CCOc1ccc(C#N)cc1)CCN1CC2CNCC(C1)O2,,C1COCCO1,,Cl,,val
US20010044538A1,O=C(c1ccncc1)C(c1ccc(F)cc1)c1ncccc1[N+](=O)[O-].O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=[N+]([O-])c1cccnc1C(=C(OS(=O)(=O)C(F)(F)F)c1ccncc1)c1ccc(F)cc1,,ClCCl,,O,c1ccncc1,val
US20060135578A1,CCOP(=O)(Cc1csc(C(C)(C)C)n1)OCC.COCOc1nn(-c2ccccc2)cc1C=O>>COCOc1nn(-c2ccccc2)cc1/C=C/c1csc(C(C)(C)C)n1,,C1CCOC1,,O,[H-].[Na+],val
US20130184463A1,C=Cc1n[nH]c2ccc(C(=O)OC)cc12>>CCc1n[nH]c2ccc(C(=O)OC)cc12,[Pd],CCO,,,,val
US20140256710A1,CN1C=CC(N)=c2ccc3c4c([nH]c(=O)c-4c21)=CCN3c1ccc(F)cc1.O=C=Nc1cccc(Oc2ccccc2)c1>>CN1C=CC(NC(=O)Nc2cccc(Oc3ccccc3)c2)=c2ccc3c4c([nH]c(=O)c-4c21)=CCN3c1ccc(F)cc1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US03947473,COC(=O)CC1(C)CCc2c(C)c(OCc3ccccc3)c(C)c(C)c2O1>>Cc1c(C)c2c(c(C)c1OCc1ccccc1)CCC(C)(CC=O)O2,,CCCCC,,CC(C)C[Al+]CC(C)C.[H-],,val
US06207693B1,CO.Nc1cccc2c(=O)oc(COCc3ccccc3)cc12>>COC(=O)c1cccc2[nH]c(COCc3ccccc3)cc12,,CO,,C[O-].[Na+],,val
US20120202785A1,NC1CCCCC1.O=[N+]([O-])c1ccc(F)cc1F>>O=[N+]([O-])c1ccc(F)cc1NC1CCCCC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US06340687B1,Cc1ccc(Cl)cc1NCCCNCC(C)C.S=C(Cl)Cl>>Cc1ccc(Cl)cc1N1CCCN(CC(C)C)C1=S,,ClC(Cl)Cl,ClCCl,CCN(CC)CC,,val
US20120302562A1,O=C(Cl)C(=O)Cl.O=C(O)CCSc1cc(F)ccc1F>>O=C(Cl)CCSc1cc(F)ccc1F,,ClCCl,,CN(C)C=O,,val
US20150065343A1,Cc1cc(/C=C/C(=O)OC(C)(C)C)sc1C=O>>Cc1cc(/C=C/C(=O)O)sc1C=O,,CCOC(C)=O,,Cl,,val
US06018046,CC(C)(C)OC(=O)CBr.O=c1c(Cc2ccccn2)cn2c3ccc(Br)cc3c3cc(O)cc1c32>>CC(C)(C)OC(=O)COc1cc2c(=O)c(Cc3ccccn3)cn3c4ccc(Br)cc4c(c1)c23,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130184263A1,CC(C)C1=C2[C@H]3CC[C@H]4[C@@](C)(CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(=O)OC(C)(C)C)CC[C@@]54C)[C@]3(C)CC[C@@]2([C@H]2CN(C3(c4ncc(Cl)cn4)CC3)C(=O)O2)CC1=O>>CC(C)C1=C2[C@H]3CC[C@H]4[C@@](C)(CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(=O)O)CC[C@@]54C)[C@]3(C)CC[C@@]2([C@H]2CN(C3(c4ncc(Cl)cn4)CC3)C(=O)O2)CC1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140088100A1,COc1cc(OC)c(Cl)c(-c2nc3cnc(Nc4c(C)cccc4[N+](=O)[O-])nc3n(C)c2=O)c1Cl>>COc1cc(OC)cc(-c2nc3cnc(Nc4c(C)cccc4N)nc3n(C)c2=O)c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20090275588A1,CCN.Cc1cn(C)nc1CCl>>CCNCc1nn(C)cc1C,,C1CCOC1,,,,val
US20100087429A1,NC1=N[C@]2(CO1)c1cc(Br)ccc1Oc1ccc(-c3cncnc3)cc12.OB(O)c1cccnc1>>NC1=N[C@]2(CO1)c1cc(-c3cccnc3)ccc1Oc1ccc(-c3cncnc3)cc12,,ClCCl,O,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20100075948A1,CC(C)(C)C/C=N/CC(=O)OC(C)(C)C.N#C/C(=C\c1cccc(Cl)c1F)c1ccc(Cl)cc1F>>CC(C)(C)CC1NC(C(=O)OC(C)(C)C)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(CC)CC,,val
US20060014702A1,CCCCCCCCCCC(CCCCCCCCCC)S[C@@H]1O[C@@H]([C@@H](COC(=O)c2ccccc2)OC(=O)c2ccccc2)[C@H](OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1>>CCCCCCCCCCC(CCCCCCCCCC)S[C@@H]1O[C@@H]([C@H](O)CO)[C@H](O)[C@H]1O,,CCOC(C)=O,,,,val
US20100004459A1,CCOC(=O)c1cccnc1-c1cccc(C#N)c1O.COc1ccc(CCCOOS(C)(=O)=O)cc1>>CCOC(=O)c1cccnc1-c1ccc(OCCCc2ccc(OC)cc2)c(C#N)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090054435A1,COC(=O)[C@H](C)O.COc1cccc(C(=O)c2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)c1O>>COc1cccc(C(=O)c2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)c1O[C@H](C)C(=O)O,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05585385,CCOC(=O)c1c(-c2ccc(F)cc2)c2ncsc2c(=O)n1C>>Cn1c(C(=O)O)c(-c2ccc(F)cc2)c2ccn(C)c2c1=O,,O=S(=O)(O)O,,,,val
US20110077400A1,CNCc1cccc(OC)c1.O=C(CBr)c1ccc2ccccc2c1>>COc1cccc(CN(C)CC(=O)c2ccc3ccccc3c2)c1,,ClCCl,,CCN(CC)CC,,val
US20090264406A1,CC(c1cc2cccnc2cc1F)c1cnc2ccc(-c3cnn(CCOC4CCCCO4)c3)nn12>>CC(c1cc2cccnc2cc1F)c1cnc2ccc(-c3cnn(CCO)c3)nn12,,C1COCCO1,ClCCl,Cl,,val
US20110098179A1,CC(C)(C)C(=O)OC(=O)C(C)(C)C.COC(=O)c1ccc(Br)c(N)c1[N+](=O)[O-]>>COC(=O)c1ccc(Br)c(NC(=O)C(C)(C)C)c1[N+](=O)[O-],,O,,O=S(=O)(O)O,,val
US20090099155A1,BrCc1cccc2cccnc12.Nc1c(Cl)ccc2c1CCN(C(=O)C(F)(F)F)CC2>>O=C(N1CCc2ccccc2CC1)C(F)(F)F,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120088748A1,CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Cl)c(Cl)c2)[C@H](C(=O)NS(C)(=O)=O)C1.CI>>CN(C(=O)[C@@H]1CN(C(=O)OC(C)(C)C)CCO[C@H]1c1ccc(Cl)c(Cl)c1)S(C)(=O)=O,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20100136136A1,CCOC(=O)COc1ccc2[nH]c(NC(=O)c3[nH]cnc3C(=O)Nc3ccc(C)cc3C)nc2c1.NCC(O)CO>>Cc1ccc(NC(=O)c2nc[nH]c2C(=O)Nc2nc3ccc(OCC(=O)NCC(O)CO)cc3[nH]2)c(C)c1,,C1CCOC1,,CC(=O)N(C)C,,val
US04731472,CCCC1(CC=C(C)Cl)Cc2cc(C(CC(=O)O)C(=O)O)c(Cl)c(Cl)c2C1=O>>CCCC1(CC=C(C)Cl)Cc2cc(CCC(=O)O)c(Cl)c(Cl)c2C1=O,[Cu],c1ccc2ncccc2c1,,Cl,,val
US05272147,CCCOc1ccccc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1.O=C1CCC(=O)N1Br>>CCCOc1ccc(Br)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1,,CN(C)C=O,,,,val
US20120142659A1,CCOC(=O)C(C(=O)OCC)C1CCCC1>>CCOC(=O)C(C(=O)O)C1CCCC1,,CCO,O,Cl,[K+].[OH-],val
US20100179210A1,COc1cc(OC)c(C2CCN(C)C2COC(C)=O)c(O)c1C(=O)CC(=O)c1ccc(Cl)cc1Br>>COc1cc(OC)c2c(=O)cc(-c3ccc(Cl)cc3Br)oc2c1[C@@H]1CCN(C)[C@H]1CO,,Cl,,O=C([O-])O.[Na+],,val
US20010000513A1,CC(C)(C)c1ccc(-c2ccc(C(=O)CCC(=O)O)cc2)cc1.NO>>CC(C)(C)c1ccc(-c2ccc(C(CCC(=O)O)=NO)cc2)cc1,,CCO,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US06011028,C1=C(N2CCCC2)CCCC1.C=Cc1ccccn1.O>>O=C1CCCCC1CCc1ccccn1,,COCCOCCOC,,,,val
US03956374,CC(=O)C(CCC(=O)O)(Cc1ccccc1Br)c1ccccc1.O=Cc1ccc(Cl)cc1>>O=C(O)CCC(Cc1ccccc1Br)(C(=O)C=Cc1ccc(Cl)cc1)c1ccccc1,,CCO,O,[Na+].[OH-],,val
US20050261244A1,CC(=O)N1C(=O)C(C)(C)c2ccccc21>>CC1(C)C(=O)Nc2ccccc21,,Cl,,,,val
US04370340,Clc1ccc(Cl)c(C2CCCCC2)c1.O=[N+]([O-])O>>O=[N+]([O-])c1cc(Cl)c(C2CCCCC2)cc1Cl,,O=S(=O)(O)O,,,,val
US06451791B1,COC(=O)[C@@H](C)N.O=Cc1cccnc1>>COC(=O)[C@@H](C)NCc1cccnc1,,CO,,Cl,[BH3-]C#N.[Na+],val
US20150368210A1,CC(C)(C)OC(=O)N1CCC(NCc2cccc(-c3cnc(N)c(NCc4c(Cl)cccc4Cl)n3)c2)C[C@@H]1C(=O)OC1CCCC1>>Nc1ncc(-c2cccc(CNC3CCN[C@@H](C(=O)OC4CCCC4)C3)c2)nc1NCc1c(Cl)cccc1Cl,,CCOCC,ClCCl,Cl,,val
US20130345212A1,O=C(O)C1(c2ccc(Br)cc2)CCCC1>>OCC1(c2ccc(Br)cc2)CCCC1,,C1CCOC1,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120108583A1,CC1(C)Cc2c(c(C(=O)O)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1.Nc1cc(C2CC2)ccc1F>>CC1(C)Cc2c(c(C(=O)Nc3cc(C4CC4)ccc3F)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1,,C1CCOC1,,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US20100160424A1,CCOC(=O)c1cccc(I)c1.Cc1ccc(Cl)cc1C=O>>CCOC(=O)c1cccc(C(O)c2cc(Cl)ccc2C)c1,,C1CCOC1,CCOC(C)=O,CC(C)[Mg]Cl,[Cl-].[NH4+],val
US20090286985A1,O=C1CCC(=O)N1Br.c1ccc2c(-c3ccc(-c4nc5ccccc5o4)cc3)c3ccccc3cc2c1>>Brc1c2ccccc2c(-c2ccc(-c3nc4ccccc4o3)cc2)c2ccccc12,,CCOC(C)=O,,Cc1ccccc1,,val
US20060014797A1,CN(C)CCc1sc2ccccc2c1C(C)(O)c1cncs1>>CC(c1cncs1)c1c(CCN(C)C)sc2ccccc12,,CC#N,ClCCl,C[Si](C)(C)Cl,[I-].[Na+],val
US20060052382A1,CCOC(=O)c1nc2n(c1C(C)=O)CCN(C(=O)OC(C)(C)C)C2>>CCOC(=O)c1nc2n(c1C(C)O)CCN(C(=O)OC(C)(C)C)C2,,CO,,[BH4-].[Na+],,val
US04705785,C/C(N)=C/C(=O)OCCO.O=C1CCCS(=O)(=O)C1.O=Cc1cccc([N+](=O)[O-])c1>>CC1=C(C(=O)OCCO)C(c2cccc([N+](=O)[O-])c2)C2=C(CCCS2(=O)=O)N1,,CCO,,C,O=C[O-].[NH4+],val
US04820834,NC1N=C(c2ccccc2)c2ccccc2NC1=O.OC(=S)c1cccc(C(F)(F)F)c1>>O=C1Nc2ccccc2C(c2ccccc2)=NC1NC(=S)c1cccc(C(F)(F)F)c1,,CN(C)C=O,,CCN(CC)CC,ClCCCl,val
US20030032764A1,CCCCCCCCCCCCCCCC(=O)O.O=C(O)CCCCC(=O)O.OCC(O)CO>>CCCCCCCCCCCCCCCC(=O)O.O=C(O)CCCCC(=O)O.OCC(O)CO,,O,,,,val
US05643932,COc1ccc(C(=O)NCC(=O)c2ccc3c(c2)CCC(=O)N3)cc1OC.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COc1ccc(-c2ncc(-c3ccc4c(c3)CCC(=O)N4)s2)cc1OC,,CO,,ClCCl,,val
US05618949,COCN(Cc1ccccc1)C[Si](C)(C)C.O=C(/C=C/c1ccccc1)N1C(=O)OC[C@@H]1c1ccccc1>>O=C1OC[C@H](c2ccccc2)N1C(=O)[C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccccc1,,CCOC(C)=O,Cc1ccccc1,O=C(O)C(F)(F)F,,val
US20150126721A1,CC(C)(C)OC[C@H]1O[C@](O[C@H]2[C@H](OCc3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@H]3OC[C@@H]2O3)([SiH](c2ccccc2)c2ccccc2)[C@H](N=[N+]=[N-])[C@@H](O)[C@@H]1OCc1ccc2ccccc2c1>>CC(C)(C)OC[C@H]1O[C@](O[C@H]2[C@H](OCc3ccccc3)[C@@H](O)[C@H]3OC[C@@H]2O3)([SiH](c2ccccc2)c2ccccc2)[C@H](N=[N+]=[N-])[C@@H](O)[C@@H]1OCc1ccc2ccccc2c1,,CO,,C[O-].[Na+],,val
US04352752,CO.COC(=O)C(Cc1ccccc1)N1C(=O)C(NC(C)=O)C1c1ccccc1>>CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)O,[Pd],CO,,,,val
US20030096981A1,C#CCCCC.Nc1nc2c(c(I)cn2[C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]1>>CCCCC#Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c2nc(N)[nH]c(=O)c12,I[Cu]I,,,CCN(CC)CC,,val
US20040192688A1,ClCCBr.Oc1ccc2ccccc2c1>>ClCCOc1ccc2ccccc2c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05830912,CCOC(=O)CC(C(C)=O)C(=O)OCC.Oc1ccc(F)c(O)c1F>>CCOC(=O)Cc1c(C)c2cc(F)c(O)c(F)c2oc1=O,,CS(=O)(=O)O,,,,val
US20020052346A1,CC(C)C[Mg]Br.CCOP(=O)(OCC)c1cc(Br)cc2ccc(C=O)nc12>>CCOP(=O)(OCC)c1cc(Br)cc2ccc(C(O)CC(C)C)nc12,,Cc1ccccc1,,C1CCOC1,,val
US05834521,CI.Nc1cccc(CC2Cc3ccccc3C2=O)c1>>CC1(Cc2cccc(N)c2)Cc2ccccc2C1=O,,C1CCOC1,ClCCl,O,[H-].[Na+],val
US20160272632A1,Cc1cc(Nc2nn([C@]3(CC#N)CCCOC3)c3cc[nH]c(=O)c23)ccc1C(=O)O.FC1(F)CCNCC1>>Cc1cc(Nc2nn([C@]3(CC#N)CCCOC3)c3cc[nH]c(=O)c23)ccc1C(=O)N1CCC(F)(F)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04780528,CC(C)OC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](C)NC(=O)OCc1ccccc1>>CC(C)OC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](C)N,[Pd],CC(=O)O,,[H][H],,val
US20080262042A1,CN(Cc1cn(S(=O)(=O)c2cccnc2Cl)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C.Cl>>CNCc1cn(S(=O)(=O)c2cccnc2Cl)c(-c2cccnc2F)c1F.Cl,,CCO,CCOC(C)=O,,,val
US20070249688A1,CCC[Mg]Cl.COC(=O)c1ccc(C(=O)N(C)OC)cc1>>CCCC(=O)c1ccc(C(=O)OC)cc1,,C1CCOC1,,,,val
US20050209324A1,COc1c(Cl)ccc2c1C(C)(C)CC(O)(C(F)(F)F)C2Nc1cccc2[nH]ncc12>>CC1(C)CC(O)(C(F)(F)F)C(Nc2cccc3[nH]ncc23)c2ccc(Cl)c(O)c21,,ClCCl,,BrB(Br)Br,,val
US20110021352A1,CCOC(=O)c1cc2ccc(Cl)nc2nc1C(F)(F)F.Oc1ccccc1>>CCOC(=O)c1cc2ccc(Oc3ccccc3)nc2nc1C(F)(F)F,,CC#N,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070257230A1,CCCCCCCBr.O=C(O)c1cc(O)ccc1O>>CCCCCCCOC(=O)c1cc(O)ccc1O,,O,,CC#N,,val
US20140228348A1,COC(=O)Cc1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1>>CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(CC(=O)O)cc3)n2)CC1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20090209586A1,O=[N+]([O-])c1ccc(F)cc1.OC1CCCCC1>>O=[N+]([O-])c1ccc(OC2CCCCC2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20150099777A1,COC(=O)c1cc(C(=O)OC)c(O)nc1C.O=P(Cl)(Cl)Cl>>COC(=O)c1cc(C(=O)OC)c(Cl)nc1C,,CC#N,,O=C([O-])O.[Na+],,val
US20060258691A1,CC(C)(C)NN=C(C(=O)OC(C)(C)C)c1ccc(F)nc1F>>CC(C)(C)OC(=O)c1nn(C(C)(C)C)c2nc(F)ccc12,,C1CCOC1,,[H-].[Na+],,val
US20060229294A1,O=C(NCCNc1nsc2ccc([N+](=O)[O-])cc12)c1ccccn1>>Nc1ccc2snc(NCCNC(=O)c3ccccn3)c2c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20090209555A1,C#CC(OCC)OCC.Cc1c(Br)nc(C(=O)N(C)C)c(=O)n1-c1cccc(C(F)(F)F)c1>>CCOC(C#Cc1nc(C(=O)N(C)C)c(=O)n(-c2cccc(C(F)(F)F)c2)c1C)OCC,[Cu]I,C1CCOC1,,CCN(CC)CC,,val
US04987232,COC(=O)C(C#N)=CC(C)=CN(C)C.Cl>>COC(=O)c1cc(C)cnc1Cl,,ClCCCl,,,,val
US04652584,CC(C)(C)N.NC(=O)c1ccc(OCC2CO2)c(I)c1>>CC(C)(C)NCC(O)COc1ccc(C(N)=O)cc1I,,O=S1(=O)CCCC1,,,,val
US20150158863A1,CCOC(=O)C(CC)P(=O)(OCC)OCC.O=Cc1ccc(OC(F)(F)F)cc1>>CCOC(=O)C(=Cc1ccc(OC(F)(F)F)cc1)CC,,C1CCOC1,,O,[H-].[Na+],val
US05763439,CC(C)(C)n1ncc(Cl)c(C(F)F)c1=O.NCc1ccncc1>>CC(C)(C)n1ncc(NCc2ccncc2)c(C(F)F)c1=O,,CCN(CC)CC,,CCO,,val
US05153352,O=C(OC1CC(CO)C1CBr)c1ccccc1>>C=C1C(CO)CC1OC(=O)c1ccccc1,,ClCCl,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20110269705A1,Cc1cc(N=C(c2ccccc2)c2ccccc2)c2occc2c1>>Cc1cc(N)c2occc2c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US04501697,COC(=O)CBr.COc1ccc(N2C(=O)[C@@H](N=[N+]=[N-])[C@H]2CO)cc1>>COC(=O)COC[C@@H]1[C@H](N=[N+]=[N-])C(=O)N1c1ccc(OC)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20030087957A1,O=Cc1ccc(OCc2ccccc2)cc1.ONC1CCCCCCC1>>[O-][N+](=Cc1ccc(OCc2ccccc2)cc1)C1CCCCCCC1,,CO,,Cl,O,val
US20120065210A1,CC(C)(C)C[C@@H]1N(CCOS(C)(=O)=O)[C@@H](C(=O)NCC[C@H]2COC(C)(C)O2)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F>>CC(C)(C)CC1N2CCN(CC[C@H]3COC(C)(C)O3)C(=O)C2C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05763437,Cc1cccc(N=C=O)c1.NC1N=C(C2CCCCC2)c2ccccc2N(CC(=O)N2CC3CCC(CC3)C2)C1=O>>Cc1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1,,ClCCl,,,,val
US20060189544A1,CCOC(=O)CC(NC(=O)CNC(=O)OC(C)(C)C)c1ccccc1>>CCOC(=O)CC(NC(=O)CN)c1ccccc1,,C1COCCO1,,Cl,,val
US20120238545A1,CCOC(=O)c1nn(-c2ccccc2)c2c1CS(=O)(=O)c1c(OC)cccc1-2>>COc1cccc2c1S(=O)(=O)Cc1c(C(=O)O)nn(-c3ccccc3)c1-2,,C1CCOC1,,[Na+].[OH-],,val
US20050267105A1,FC(F)(F)C1(c2cccc(CBr)c2)N=N1.O=C1NC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1Cc1cccc(C2(C(F)(F)F)NN2)c1,,CN(C)C=O,,[K],,val
US20110053924A1,COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)[C@@H](CC(C)=O)C[C@@H]3c3ccc(COC[C@@H](C)COC)cc3)cc21>>COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)[C@@H](C[C@H](C)O)C[C@@H]3c3ccc(COC[C@@H](C)COC)cc3)cc21,,C1CCOC1,,B,,val
US06046210,O=C(NCCCCN1CCc2ccc(O)cc2C1)c1ccc(-c2ccccc2)cc1.O=S(=O)(Cl)c1cccnc1>>O=C(NCCCCN1CCc2ccc(OS(=O)(=O)c3cccnc3)cc2C1)c1ccc(-c2ccccc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20140127156A1,CI.COc1ccc2c(Cl)ncc(NC(=O)c3ccccc3)c2c1>>COc1ccc2c(Cl)ncc(N(C)C(=O)c3ccccc3)c2c1,,CN(C)C=O,,[H-].[Na+],,val
US20110009395A1,C=CCOCC(=NO)c1cc(Br)ccc1F>>Fc1ccc(Br)cc1C12COCC1CON2,,Cc1ccccc1C,,,,val
US20090029975A1,CCN(CC)CCO.CS(=O)(=O)c1cc(CCC(=O)O)nc(-c2nc(=O)c3ccc(Cl)cc3s2)c1>>CCN(CC)CCOC(=O)CCc1cc(S(C)(=O)=O)cc(-c2nc(=O)c3ccc(Cl)cc3s2)n1,CN(C)c1ccncc1,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20090239854A1,CC1CCCNC1.Cc1ccc2c(c1)c1c(n2CC(=O)O)CCN(C)C1>>Cc1ccc2c(c1)c1c(n2CC(=O)N2CCCC(C)C2)CCN(C)C1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20090281131A1,COC(OC)N(C)C.COc1ccc(C2(C#N)CCC(=O)CC2)c2c1oc1ccccc12>>COc1ccc(C2(C#N)CCC(=O)/C(=C/N(C)C)C2)c2c1oc1ccccc12,,c1ccccc1,,,,val
US20080242685A1,CC(C)(C)OC(=O)N1CCC(c2n[nH]c3c(C(N)=O)nc(-c4ccccc4)nc23)CC1>>NC(=O)c1nc(-c2ccccc2)nc2c(C3CCNCC3)n[nH]c12,,CO,,Cl,,val
US20150087663A1,O=C(Nc1cccc(F)c1)c1c(Cl)cccc1[N+](=O)[O-]>>Nc1cccc(Cl)c1C(=O)Nc1cccc(F)c1,[Fe],CCO,O,O=C[O-].[NH4+],,val
US20080026331A1,COC(=O)C1C2CC3C(OC(=O)C31)C2O.O=C(Cl)CCl>>COC(=O)C1C2CC3C(OC(=O)C31)C2OC(=O)CCl,,C1CCOC1,,c1ccncc1,O=C([O-])O.[Na+],val
US20090156610A1,CC(C)(C)OC(=O)CN1CCC(Oc2ccc(I)cc2C2NC(=O)CC(c3cccc(Cl)c3)C23C(=O)Nc2cc(Cl)ccc23)CC1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C(O)CN1CCC(Oc2ccc(I)cc2C2NC(=O)CC(c3cccc(Cl)c3)C23C(=O)Nc2cc(Cl)ccc23)CC1,,ClCCl,,,,val
US20110028467A1,Cc1cnc(O)c(N)c1.O=C(Cl)CCl>>CN1C=CC=C2NC(=O)COC21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04539150,C1COCCO1.CCOC(=O)CNC1CSc2ccccc2N(OC(C)(C)C)C1=O.Cl>>CCOC(=O)CNC1CSc2ccccc2N(CC(=O)O)C1=O.Cl,,C1COCCO1,,,,val
US20060135554A1,CCOC(=O)CCNc1ccc(C(=O)N(CC)CC)cc1[N+](=O)[O-]>>CCOC(=O)CCNc1ccc(C(=O)N(CC)CC)cc1N,[Pd],CCOC(C)=O,,,,val
US20090233919A1,COc1cc([N+](=O)[O-])ccc1C#CCN1CCCC1>>COc1cc(N)ccc1CCCN1CCCC1,[Pd],CCO,,,,val
US20040048915A1,COC(=O)C(=O)c1cccc2ccn(COCC[Si](C)(C)C)c12.NC(=O)Cc1c[nH]c2ccccc12>>C[Si](C)(C)CCOCn1ccc2cccc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c21,,CN(C)C=O,,C1CCOC1,CC(C)(C)[O-].[K+],val
US04699910,C#CCCl.Cl.FC(F)(F)c1cccc(N2CCNCC2)c1>>C#CCN1CCN(c2cccc(C(F)(F)F)c2)CC1.Cl,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20070197635A1,CC1(CCC2=C3CCC4(C)C(=O)CCC4C3OCC2=O)OCCO1>>CC(=O)CCC1=C2CCC3(C)C(=O)CCC3C2OCC1=O,,CC(C)=O,,Cl,,val
US20040192733A1,COC(=O)C1(CS(=O)(=O)Cl)CCOCC1.FC(F)(F)c1ccc(OC2CCNCC2)cc1>>COC(=O)C1(CS(=O)(=O)N2CCC(Oc3ccc(C(F)(F)F)cc3)CC2)CCOCC1,,ClCCl,,CCN(CC)CC,O,val
US05744426,Cn1nc(-c2cc(C=C(Cl)C(=O)O)c(Cl)cc2Cl)c(Cl)c1OC(F)F.O=C(Cl)C(=O)Cl>>Cn1nc(-c2cc(C=C(Cl)C(=O)Cl)c(Cl)cc2Cl)c(Cl)c1OC(F)F,CN(C)C=O,Cc1ccccc1,,,,val
US20070142471A1,CCCCCC(O[Si](C)(C)C(C)(C)C)c1ccc(CI)cc1.CCOC(=O)CCCCCCNS(C)(=O)=O>>CCCCCC(O[Si](C)(C)C(C)(C)C)c1ccc(CCS(=O)(=O)NCCCCCCC(=O)OCC)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20100249374A1,CCCCCCCCCCCCCCCCCCCCCCOc1ccc(C(Cl)c2ccc(OCCCCCCCCCCCCCCCCCCCCCC)cc2)cc1.NCc1ccccc1>>CCCCCCCCCCCCCCCCCCCCCCOc1ccc(C(NCc2ccccc2)c2ccc(OCCCCCCCCCCCCCCCCCCCCCC)cc2)cc1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20130053386A1,Fc1ccc(C(F)(F)F)cc1.O=c1cc(-c2cccc(Br)c2)[nH]n1CCO>>OCCn1nc(-c2cccc(Br)c2)cc1Oc1ccc(C(F)(F)F)cc1,,CC(=O)N(C)C,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20120295884A1,CC(=O)c1nc(CC(=O)O)n2ccccc12.CC(C)(C)OC(=O)N1[C@@H]2C[C@]2(CO)C[C@H]1C(=O)NCc1cccc(Cl)c1F>>CC(=O)c1nc(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)NCc2cccc(Cl)c2F)n2ccccc12,,CO,ClCCl,,,val
US20080114002A1,CS(=O)(=O)c1ccc(F)c(C(F)(F)F)c1.O=C(O)CCc1ccc(Cl)cc1S>>CS(=O)(=O)c1ccc(Sc2cc(Cl)ccc2CCC(=O)O)c(C(F)(F)F)c1,,CN(C)C=O,,[H-].[Na+],,val
US20070161626A1,CC(C)(C)OC(=O)Nc1ccc(B(O)O)cc1.N#Cc1ccc(OS(=O)(=O)C(F)(F)F)c(F)c1F>>CC(C)(C)OC(=O)Nc1ccc(-c2ccc(C#N)c(F)c2F)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20050267170A1,CCO.O=C(O)c1cc(Cl)cnc1Cl>>CCOC(=O)c1cc(Cl)cnc1Cl,,Cc1ccccc1,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20080045532A1,C1CCNC1.O=C(O)Cc1ccc(-n2nc(C(F)(F)F)c3c2CCCC3)cc1>>O=C(Cc1ccc(-n2nc(C(F)(F)F)c3c2CCCC3)cc1)N1CCCC1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20120207703A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.COC(=O)[C@@H]1CC[C@@H](O)C[C@H]1C(=O)OCc1ccccc1>>COC(=O)[C@@H]1CC[C@@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C[C@H]1C(=O)OCc1ccccc1,,CN(C)C=O,ClCCl,c1c[nH]cn1,,val
US20050234244A1,COc1cc2c(CC(=O)O)c(C)n(C(=O)c3ccc(Cl)cc3)c2cc1F>>Cc1c(CC(=O)O)c2cc(O)c(F)cc2n1C(=O)c1ccc(Cl)cc1,,ClCCl,,BrB(Br)Br,,val
US05807688,CCOP(=O)(Cc1ccc([N+](=O)[O-])cc1)OCC.ClP(Cl)(Cl)(Cl)Cl>>CCOP(=O)(Cl)Cc1ccc([N+](=O)[O-])cc1,,ClC(Cl)(Cl)Cl,ClCCl,,,val
US20040116424A1,CCc1cccc(CC)c1C1N(Cl)C(Cl)=C(C(C)OC)N1CCOC.CN(C)C=O>>CCc1cccc(CC)c1-c1nc(C(C)OC)c(Cl)n1C=O,,C1CCOC1,,[Li]CCCC,,val
US20060264435A1,Cc1nc(Br)ncc1Br.OC1CNC1>>Cc1nc(N2CC(O)C2)ncc1Br,,CCO,,CCN(CC)CC,Cl,val
US05329052,CC(CBr)C1OCCO1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C[P+](c1ccccc1)(c1ccccc1)c1ccccc1)C1OCCO1.[Br-],,Cc1ccccc1,,,,val
US20080280906A1,CCN(C(=O)C(F)F)c1cnoc1C>>CCN(C(=O)C(F)F)/C(=C\N)C(C)=O,[Pd],,,,,val
US20100261728A1,C1=NCCc2ccccc21.FC(F)(F)c1ccc(Br)cn1.O=C(Cl)OCc1ccccc1>>O=C(OCc1ccccc1)N1CCc2ccccc2C1c1ccc(C(F)(F)F)nc1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20070099990A1,CN(C)C=O.Cc1cc(C)c2c(c1C)OCC2c1cccc(Br)c1>>Cc1cc(C)c2c(-c3cccc(C=O)c3)coc2c1C,,C1CCOC1,,O,[Li]CCCC,val
US20080234255A1,CN1C(=O)C(C)(C)CN(C2CCCC2)c2nc(Cl)ncc21.Cc1cc(C(=O)O)ccc1N>>Cc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(C)(C)C(=O)N2C,Cl,O,,CCO,,val
US20100261900A1,C#Cc1ccc(OC)cc1.Cc1ccc(S(=O)(=O)Oc2cc(C)ncn2)cc1>>COc1ccc(C#Cc2cc(C)ncn2)cc1,,CCCCCCC,CCOC(C)=O,,,val
US05877174,N=C(NC(=O)OCc1ccccc1)c1ccc(OCCCCN2CCNC(=O)C2=O)cc1.O=C(OC(c1ccccc1)c1ccccc1)C(Br)c1ccccc1>>N=C(NC(=O)OCc1ccccc1)c1ccc(OCCCCN2CCN(C(C(=O)OC(c3ccccc3)c3ccccc3)c3ccccc3)C(=O)C2=O)cc1,,CN(C)C=O,O,CCOC(C)=O,[H-].[Na+],val
US20120295915A1,CC(C)(C)OC(=O)N1CCC(CN)C1.O=[N+]([O-])c1cnccc1Cl>>CC(C)(C)OC(=O)N1CCC(CNc2ccncc2[N+](=O)[O-])C1,,CC(C)O,,,,val
US20080070903A1,O=C(OCCC(c1ccccc1)c1ccccc1)C1=C(COCCC2CCCCC2)NC(c2ccccc2)=NC1c1cccc(Cl)c1>>O=C(OCCC(c1ccccc1)c1ccccc1)c1c(COCCC2CCCCC2)nc(-c2ccccc2)nc1-c1cccc(Cl)c1,,c1ccccc1,,O,,val
US06359134B1,CC(C)N(Cc1ccc(Br)cc1)C(C)C.CON(C)C(=O)C1CCN(C(c2ccccc2)(c2ccccc2)c2ccccc2)CC1>>CC(C)N(Cc1ccc(C(=O)C2CCN(C(c3ccccc3)(c3ccccc3)c3ccccc3)CC2)cc1)C(C)C,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20100098634A1,CI.NC(=O)c1ccc2cc(-c3cccc([N+](=O)[O-])c3)cn2c1>>CNC(=O)c1ccc2cc(-c3cccc([N+](=O)[O-])c3)cn2c1,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20140256729A1,CC(C)(C)OC(=O)N[C@H]1CC[C@@H](N[C@@H]2C[C@H]2c2ccccc2)CC1.Cl>>Cl.N[C@H]1CC[C@@H](N[C@@H]2C[C@H]2c2ccccc2)CC1,,C1COCCO1,,,,val
US20150031727A1,CCC(CC)N(CCNC)Cc1cccc(C(=O)Nc2sc3c(c2C(=O)Nc2ccc(CCc4ccc(C(=O)OC)cc4)cc2)CCCC3)c1.COC(=O)COC(=O)Oc1ccc([N+](=O)[O-])cc1>>CCC(CC)N(CCN(C)C(=O)OCC(=O)OC)Cc1cccc(C(=O)Nc2sc3c(c2C(=O)Nc2ccc(CCc4ccc(C(=O)OC)cc4)cc2)CCCC3)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20150031693A1,CCn1c(=O)c(-c2ccc(-c3cncc(C)n3)cc2Cl)cc2cnc(Cl)nc21.C[Si](C)(C)OCCCN>>CCn1c(=O)c(-c2ccc(-c3cncc(C)n3)cc2Cl)cc2cnc(NCCCO[Si](C)(C)C)nc21,,CC(C)O,,CCN(CC)CC,,val
US05362743,CCOC(=O)CCC(=O)c1cnc2c(OC)cccc2c1Cl.Cc1ccccc1N>>CCOC(=O)CCC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C,,C1CCOC1,,,,val
US20090036492A1,CC(=O)C1=C(O)C=C2Oc3c(C(N)=O)c(OCc4ccccc4)cc(O)c3[C@]2(C)C1=O.O=Cc1ccccc1>>CC(=O)C1=C(O)C=C2Oc3c(C(=O)NCc4ccccc4)c(OCc4ccccc4)cc(O)c3[C@]2(C)C1=O,,Cc1ccccc1,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US05227399,COC(OC)c1cc(OCc2ccccc2)ccc1C(O)c1ccccc1.O=C1C=CC(=O)O1>>O=C1OC(=O)c2c1cc1cc(OCc3ccccc3)ccc1c2-c1ccccc1,,Cc1ccccc1,,,,val
US20090143361A1,COc1ccc2nc(C)c3c(C)nc(-c4cc(Cl)cc(Cl)c4)n3c2n1.Cc1cc(Cl)ccc1B(O)O>>COc1ccc2nc(C)c3c(C)nc(-c4ccc(Cl)cc4C)n3c2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20120329780A1,COc1ccc(Cn2cc3nc(C4CCN(C)CC4)nc(Cl)c3n2)cc1.Nc1cc[nH]n1>>CN1CCC(c2nc(Nc3cc[nH]n3)c3[nH]ncc3n2)CC1,C1COCCO1,CO,,Cl,,val
US20110046147A1,COc1ccc(C(Br)C(Br)C(=O)c2cccc(OC)c2)cc1.NO>>COc1ccc(-c2cc(-c3cccc(OC)c3)no2)cc1,,O,,CCO,Cl,val
US20090093485A1,Cc1ccc(S(=O)(=O)OC[C@H](C)N2C(=O)c3ccccc3C2=O)cc1.Oc1cccc2cnccc12>>C[C@@H](COc1cccc2cnccc12)N1C(=O)c2ccccc2C1=O,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120115862A1,COc1cccc(C(=O)O)c1C.O=C1CCC(=O)N1Br>>COc1cccc(C(=O)O)c1CBr,,Clc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US04667038,CCOC(=O)C1Cc2cc(OC)c(OC)cc2CN1C.COc1ccc(C(C#N)(CCCI)C(C)C)cc1OC>>CCOC(=O)C1(CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)Cc2cc(OC)c(OC)cc2CN1C,,C1CCOC1,,Cl,CC(C)[N-]C(C)C.[Li+],val
US20030199440A1,CN(CC(=O)OC(C)(C)C)S(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1.N=C(N)N>>CN(CC(=O)OC(C)(C)C)S(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1,,COCCOC,,Cl,[H-].[Na+],val
US20160120864A1,COc1ccc(-n2c(C(=O)N3CCN(C)CC3)c(OCc3ccccc3)c(OCc3ccccc3)c2C(=O)N2CCN(C)CC2)cc1>>COc1ccc(-n2c(C(=O)N3CCN(C)CC3)c(O)c(O)c2C(=O)N2CCN(C)CC2)cc1,[Pd],CO,,[H][H],,val
US20070072859A1,CNOC.O=C(Cl)CCBr>>CON(C)C(=O)CCBr,,ClCCl,,Cl,c1ccncc1,val
US20080269220A1,CC(C)COc1ccc(C=O)cc1CCl.c1ccc(CCNc2nc(-c3ccccc3)cs2)cc1>>CC(C)COc1ccc(C=O)cc1CN(CCc1ccccc1)c1nc(-c2ccccc2)cs1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20090137561A1,CCc1cccc(-c2ccc(C(=O)OC)cc2C2=CCCC2(C)C)c1>>CCc1cccc(-c2ccc(C(=O)OC)cc2C2CCCC2(C)C)c1,[Pd],CO,,,,val
US20090306052A1,CNC(=O)c1ccc(Cl)nc1.C[C@@H]1CC[C@@H](C)N1C1Cc2ccc(O)cc2C1>>CNC(=O)c1ccc(Oc2ccc3c(c2)CC(N2[C@H](C)CC[C@H]2C)C3)nc1,,CN(C)C=O,,[H-].[Na+],,val
US20070225340A1,CCC(CC)CBr.CCOC(=O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2O)n1>>CCOC(=O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCC(CC)CC)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120225844A1,CI.O=C1NCCn2nc(COc3ccccc3)cc21>>CN1CCn2nc(COc3ccccc3)cc2C1=O,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US05624942,COc1cc(Cl)nc(OCc2ccsc2)c1.Oc1cccc(C(F)(F)F)c1>>COc1cc(OCc2ccsc2)nc(Oc2cccc(C(F)(F)F)c2)c1,[Cu]I,CN(C)C=O,,[H-].[Na+],,val
US05502054,C[Si](C)(C)CCC(=O)Cl.N#C[Cu]>>C[Si](C)(C)CCC(=O)C#N,,ClCCl,,,,val
US20150291533A1,CCOC(=O)C1=Cc2ccccc2N(S(=O)(=O)c2ccc(C)cc2)CC1>>CCOC(=O)C1CCN(S(=O)(=O)c2ccc(C)cc2)c2ccccc2C1,[Pd],CCO,,,,val
US20110152250A1,BrCc1ccccc1.COC(=O)n1ncc2c(NC(=O)NCC3CCc4ccccc4N3)cccc21>>COC(=O)n1ncc2c(NC(=O)NCC3CCc4ccccc4N3Cc3ccccc3)cccc21,,C1CCOC1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20100239525A1,CNC1CCCCC1.CS(=O)(=O)OCCc1ccc(Nc2ncc3c(n2)-c2ccccc2[C@H](c2ccc(F)cc2)C3)cc1>>CN(CCc1ccc(Nc2ncc3c(n2)-c2ccccc2[C@H](c2ccc(F)cc2)C3)cc1)C1CCCCC1,,CCN(CC)CC,,,,val
US20100210672A1,Brc1cnsc1.COc1ncc(B(O)O)c(OC)n1>>COc1ncc(-c2cnsc2)c(OC)n1,,COCCOC,O,O=C([O-])O.[Na+],,val
US20040049039A1,NCc1ccccc1F.O=Cc1nc2ccc(F)cc2c(=O)n1-c1ccccc1Cl>>O=c1c2cc(F)ccc2nc(CNCc2ccccc2F)n1-c1ccccc1Cl,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130102776A1,Cc1ccc2c(/C=C3\Oc4c(ccc(O)c4CN4CCN(C(=O)OC(C)(C)C)CC4)C3=O)c[nH]c2n1.Cl.ClCCl>>Cc1ccc2c(/C=C3\Oc4c(ccc(O)c4CN4CCNCC4)C3=O)c[nH]c2n1.Cl.Cl.Cl,,C1COCCO1,ClCCl,,,val
US20090143385A1,Cc1onc(-c2ccccc2)c1COc1ccc(Br)nn1>>Cc1onc(-c2ccccc2)c1COc1cccnn1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20120058984A1,CCc1ccc2nc(N)sc2c1.Fc1cc(Cc2ccccc2)nc(F)n1>>CCc1ccc2nc(Nc3cc(Cc4ccccc4)nc(F)n3)sc2c1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],[Cl-].[NH4+],val
US05306728,BrC/C=C/c1ccsc1.CCN(C/C=C/C#CC(C)(C)OC)Cc1cc(CO)ccn1>>CCN(C/C=C/C#CC(C)(C)OC)Cc1cc(COC/C=C/c2ccsc2)ccn1,,C1CCOC1,,CCOCC,[H-].[Na+],val
US20090105275A1,CCC(=O)c1ccc(C(F)(F)F)cc1>>CCC(O)c1ccc(C(F)(F)F)cc1,,CO,,[BH4-].[Na+],,val
US20080015199A1,Fc1cccnc1Cl.NN>>NNc1ncccc1F,,CCO,,O,,val
US20140336185A1,COc1ccc(CC(=O)Nc2ccc(C(=O)N(CC(=O)OC(C)(C)C)Cc3ccc(-c4coc(-c5ccc(Br)cc5)n4)cc3)cc2)c(C(F)(F)F)c1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(CC(=O)Nc2ccc(C(=O)N(CC(=O)O)Cc3ccc(-c4coc(-c5ccc(-c6ccc(C)cc6)cc5)n4)cc3)cc2)c(C(F)(F)F)c1,,ClCCl,,,,val
US20120022030A1,COC(=O)CC(=O)NC1(CC(=O)OC)CN(C(=O)OC(C)(C)C)C1>>COC(=O)C1C(=O)CC2(CN(C(=O)OC(C)(C)C)C2)NC1=O,,CO,Cc1ccccc1,[Na],,val
US20090270350A1,CSc1ccccc1Cn1c(C)cc(O)cc1=O.O=C1CCC(=O)N1I>>CSc1ccccc1Cn1c(C)cc(O)c(I)c1=O,,CC#N,,,,val
US20020002187A1,CC(=O)OC(C)=O.Cc1sc2cc3ccccc3c(-c3ccc(O)cc3)c2c1C>>CC(=O)Oc1ccc(-c2c3ccccc3cc3sc(C)c(C)c23)cc1,,c1ccncc1,,Cl,,val
US20100179126A1,Cc1ncc(C2CCN(C)CC2(C)C)cc1N/C(=N/C(=O)OC(C)(C)C)NC(=O)OC(C)(C)C>>Cc1ncc(C2CCN(C)CC2(C)C)cc1NC(=N)N,,ClCCl,,Cl,,val
US04980360,CC(I)CCCN1C(=O)c2ccccc2C1=O.COc1cc(N)c2nccc(C)c2c1OCCCCCCc1ccccc1>>COc1cc(NC(C)CCCN2C(=O)c3ccccc3C2=O)c2nccc(C)c2c1OCCCCCCc1ccccc1,,CCOCC,,CCN(CC)CC,Cl,val
US05202243,CCc1cc(C(=O)OC)c(OC)nc1C>>CCc1cc(CO)c(OC)nc1C,,C1CCOC1,C1CCOC1,[H-].[Na+],,val
US20050143381A1,O=c1[nH]nc2c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)cnn12.OCCNc1ccccc1>>O=c1n(CCNc2ccccc2)nc2c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)cnn12,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120010228A1,COC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCNCC3)C2=O)c1.O=C(CCCI)c1ccc(F)cc1>>COC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCN(CCCC(=O)c4ccc(F)cc4)CC3)C2=O)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030144135A1,C[Si](C)(C)OCCCC1([Zr+2]C2C=CC=C2)C=CC=C1.[Cl-].[Cl-]>>OCCCC1([Zr+2]C2C=CC=C2)C=CC=C1.[Cl-].[Cl-],,Cc1ccccc1,,,,val
US20040063940A1,COc1cccc(C(O)(CN)c2ccc(Br)cc2)c1.O=C(Cl)CCl>>COc1cccc(C(O)(CNC(=O)CCl)c2ccc(Br)cc2)c1,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,O,val
US20160157491A1,Cn1nc2c(ccc3cc(CO)ccc32)c1-c1ccc(OC(F)(F)F)cc1>>Cn1nc2c(ccc3cc(C=O)ccc32)c1-c1ccc(OC(F)(F)F)cc1,O=[Mn]=O,ClC(Cl)Cl,,,,val
US05219871,CNCCCC(C(N)=O)(c1ccccc1)c1ccccc1.COC(=O)Cc1ccc(CCBr)cc1>>COC(=O)Cc1ccc(CCN(C)CCCC(C(N)=O)(c2ccccc2)c2ccccc2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130005744A1,CI.O=c1[nH]cc(-c2cccc(-c3ccccc3)c2)c(F)c1OCc1ccccc1>>Cn1cc(-c2cccc(-c3ccccc3)c2)c(F)c(OCc2ccccc2)c1=O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090136448A1,COC(CC(C)=O)OC.Nc1cc(-c2ccc(Br)cc2)n[nH]1>>Cc1ccn2nc(-c3ccc(Br)cc3)cc2n1,,CCO,,,,val
US20050107449A1,CC(N)=S.N#Cc1ccc(-c2ccccc2F)nc1>>NC(=S)c1ccc(-c2ccccc2F)nc1,,C1COCCO1,Cl,O=C([O-])O.[Na+],,val
US20110172278A1,CCNC(=S)Nc1ccc(C(=O)OC)cc1.O=C(CBr)c1ccccc1>>CCn1c(-c2ccccc2)cs/c1=N\c1ccc(C(=O)OC)cc1,,CO,,,,val
US20030153568A1,CC#N.CCNC(=O)Nc1nc2ccc(C(=O)OCC)cc2s1>>CCNC(=O)Nc1nc2ccc(C(=O)CC#N)cc2s1,,CN(C)C=O,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20030092140A1,CCC[C@@H](O)[C@H](C)C(=O)n1c(=O)oc2ccccc21.NCc1ccccc1>>CCC[C@@H](O)[C@H](C)C(=O)NCc1ccccc1,,C1CCOC1,,,,val
US20080318930A1,CCS(=O)(=O)CCCC12CCC(C(=O)O)(CC1)CC2.NC1C2CC3CC(C2)CC1C3>>CCS(=O)(=O)CCCC12CCC(C(=O)NC3C4CC5CC(C4)CC3C5)(CC1)CC2,,CCN(CC)CC,ClCCl,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US05187156,CC(C)(C)OC(=O)N[C@@H](CCC(=O)OCC(Cl)(Cl)Cl)C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N[C@@H](CCC(=O)OCC(Cl)(Cl)Cl)C(=O)O,[Pd],CCO,,,,val
US20090163471A1,BrC1CC1.CON(C)C(=O)c1ccc(Cl)nc1>>O=C(c1ccc(Cl)nc1)C1CC1,,C1CCOC1,,[Li]CCCC,,val
US20130317045A1,Cc1cc(N)n[nH]1.O=C(c1ccc(F)cc1)c1nc(Cl)c2sccc2n1>>Cc1cc(Nc2nc(C(=O)c3ccc(F)cc3)nc3ccsc23)n[nH]1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20090099195A1,COC(=O)c1cc2ccc(Cl)cc2cn1>>OCc1cc2ccc(Cl)cc2cn1,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20130261106A1,CC(C)Oc1cc(N2CCN3CCC[C@@H]3C2)ccc1[N+](=O)[O-]>>CC(C)Oc1cc(N2CCN3CCC[C@@H]3C2)ccc1N,[Pd],CCO,,NN,O,val
US20150023913A1,CCOC(=O)C(C)(O)CC1CC1>>CC(O)(CC1CC1)C(=O)O,,CO,,[Li+].[OH-],,val
US20070232611A1,CN1C(=O)N(c2cc(N)ccc2Cl)Cc2cnc(S(C)(=O)=O)nc21.O=C(O)c1ccc(-c2ccccc2)cc1>>CN1C(=O)N(c2cc(NC(=O)c3ccc(-c4ccccc4)cc3)ccc2Cl)Cc2cnc(S(C)(=O)=O)nc21,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US05373004,CC1(O)CCCC1CS(=O)(=O)c1ccccc1.CC[Si](CC)(CC)OS(=O)(=O)C(F)(F)F.CC[Si](Cl)(CC)CC.Cc1cccc(C)n1.c1c[nH]cn1>>CC1(O)CCCC1CSc1ccccc1.CC[Si](CC)(CC)OC1(C)CCCC1CS(=O)(=O)c1ccccc1,,ClCCl,,,,val
US20090326074A1,CC#N.O=Cc1cccc(OCC2CCC(F)(F)CC2)c1>>N#CCC(O)c1cccc(OCC2CCC(F)(F)CC2)c1,,C1CCOC1,CCOC(C)=O,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US04923993,C=C(C=CN(C)C)NC.C=C(Cl)C#N.CCN(CC)CC>>CCc1ccc(C#N)nc1,,CC#N,,,,val
US06124283,CN1CCN(c2cccc3c2C[C@H](N)CC3)CC1.O=C(Cl)c1cccc(C(F)(F)F)c1>>CN1CCN(c2cccc3c2C[C@H](NC(=O)c2cccc(C(F)(F)F)c2)CC3)CC1,,ClCCl,,CCN(CC)CC,,val
US20160272595A1,CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2cc(CN3CCNCC3)c(Br)cc2c1=O.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2cc(CN3CCN(CC(F)(F)F)CC3)c(Br)cc2c1=O,,C1CCOC1,CS(C)=O,CCN(C(C)C)C(C)C,O,val
US20120214803A1,Nc1cccc2cccnc12.O=S(=O)(Cl)c1cncc(C(F)(F)F)c1>>O=S(=O)(Nc1cccc2cccnc12)c1cncc(C(F)(F)F)c1,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20080139663A1,CC(C)CC(N)C1(c2ccc(Cl)cc2)CCC1.CCOC(=O)C=O>>CCOC(=O)CNC(CC(C)C)C1(c2ccc(Cl)cc2)CCC1,,CC(=O)O,CN(C)C=O,O=C([O-])O.[Na+],,val
US20080280906A1,Cc1oncc1N(C(=O)C1CC1)C(C)C>>CC(=O)/C(=C/N)N(C(=O)C1CC1)C(C)C,[Pd],CCO,,[H][H],,val
US20150367338A1,COCc1cc(OC)c(OC)c(C(O)C(C)(C)C)c1>>COCc1cc(OC)c(OC)c(C(=O)C(C)(C)C)c1,O=[Mn]=O,ClCCl,,,,val
US20120248969A1,CC(C)C(=S)Nc1ccc2c(c1)Cc1ccccc1-2.NNC(=O)c1ccccc1>>CC(C)c1nnc(-c2ccccc2)n1-c1ccc2c(c1)Cc1ccccc1-2,,CCCCO,,,,val
US20110034507A1,COC(=O)c1ccnc(-c2ccc3cc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)ccc3c2)c1>>CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc2cc(-c3cc(C(=O)O)ccn3)ccc2c1,,C1CCOC1,,CO,[Na+].[OH-],val
US06919328B1,Br.N=C(Sc1ccccc1)c1cccs1.Nc1ccc2c(c1)C(=O)Nc1ccccc1O2>>Br.N=C(Nc1ccc2c(c1)C(=O)Nc1ccccc1O2)c1cccs1,,CO,,,,val
US20080234260A1,CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccc(C(=O)O)cc3)cs2)CC1>>O=C(O)c1ccc(-c2csc(N3CCNCC3)n2)cc1,,C1COCCO1,Cl,,,val
US20030220348A1,COc1cnc(CCl)c(OC)n1.Fc1cccc(-c2ncc[nH]2)n1>>COc1cnc(Cn2ccnc2-c2cccc(F)n2)c(OC)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090176732A1,CCOC(C)(OCC)OCC.COC(=O)C(C#N)(CO)CO>>CCOC1(C)OCC(C#N)(C(=O)OC)CO1,,C1CCOC1,,O=S(=O)(O)O,,val
US05466692,Cc1nc(CO)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nnnn2C(C)(C)C)cc1>>Cc1nc(CO)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,Cc1ccccc1,,CS(=O)(=O)O,,val
US20110311447A1,C1=CCNCC1.O=C(Cl)c1ccccc1>>O=C(c1ccccc1)N1CC=CCC1,,ClCCl,,CCN(CC)CC,,val
US04996358,CC(C)C[C@@H](O)C(=O)O.O=[N+]([O-])c1ccc(CBr)cc1>>CC(C)C[C@@H](O)C(=O)OCc1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,,CCN(CC)CC,,val
US20030212012A1,CC(C)(C)OC(=O)N1CC(=O)C[C@H]1C(=O)O.CO>>COC(=O)[C@@H]1CC(=O)CN1C(=O)OC(C)(C)C,,Cc1ccccc1,,C[Si](C)(C)C=[N+]=[N-],,val
US20080009617A1,COC(=O)Nc1ccccc1CC(=O)NC1CCN(Cc2ccccc2)CC1>>O=C1Nc2ccccc2CCN1C1CCNCC1,[Pd],CO,,[H][H],,val
US20140057893A1,CC1(OC(=O)N2CCC([C@H]3C[C@H]3CCO)CC2)CC1.Oc1ccc(-n2cncn2)cn1>>CC1(OC(=O)N2CCC([C@H]3C[C@H]3CCOc3ccc(-n4cncn4)cn3)CC2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20040142921A1,BrCCBr.COC(=O)C(Cc1ccc(O)cc1)NC(C)=CC(=O)c1ccc(F)cc1>>COC(=O)C(Cc1ccc(OCCBr)cc1)NC(C)=CC(=O)c1ccc(F)cc1,,CCO,,[K+].[OH-],,val
US20070281990A1,CN(C)CC/C=C1/c2ccccc2COc2ccc(O)cc21>>CN(C)CC/C=C1\c2ccccc2COc2ccc(O)cc21,,CO,Cl,,,val
US20090182025A1,CC#N.COc1ccc(C#N)cc1F>>COc1ccc(C(N)=CC#N)cc1F,,O=C([O-])O,[Na+],C1CCOC1,CC(C)(C)[O-].[K+],val
US20080319019A1,O=C(NC1CCC(F)(F)CC1)c1nc(-c2ccc(Cl)cc2Cl)n(-c2ccc(O)cc2)c1CO.O=S(=O)(Cl)CCC(F)(F)F>>O=C(NC1CCC(F)(F)CC1)c1nc(-c2ccc(Cl)cc2Cl)n(-c2ccc(OS(=O)(=O)CCC(F)(F)F)cc2)c1CO,,ClCCl,,CCN(CC)CC,,val
US20110053952A1,COc1ccc(-c2cnc(Nc3cnc(C)c(NC(=O)OC(C)(C)C)c3)nc2)cc1>>COc1ccc(-c2cnc(Nc3cnc(C)c(N)c3)nc2)cc1,,ClCCl,O,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20100179137A1,C1COCCO1.CC(=O)OCCCS(N)(=O)=O.CCc1cccc(OCc2c(Cl)cc(Cl)c(=O)n2CCc2ccc(C(=O)n3ccnc3)cc2)c1>>CCOc1cccc(OCc2c(Cl)cc(Cl)c(=O)n2CCc2ccc(C(=O)NS(=O)(=O)CCCOC(C)=O)cc2)c1,,O,,C1CCC2=NCCCN2CC1,Cl,val
US06130187,BrBr.Cc1cc2c(Cl)ccc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c2o1>>Cc1oc2c(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)ccc(Cl)c2c1Br,,CC(=O)O,,O,,val
US20030139544A1,C1=CCC(C23CCC(CC2)C3)=C1.CC(C)=O>>CC(C)=C1C=CC(C2CC3CCC2C3)=C1,,CCOCC,CO,O,C[O-].[Na+],val
US20020007060A1,CCOC(=O)CNC.Cc1ccc(S(=O)(=O)Cl)cc1>>CCOC(=O)CN(C)S(=O)(=O)c1ccc(C)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20070066618A1,CCc1nc2c(C)cc(C)nc2n1-c1ccc(CCO)cc1.O=S(Cl)Cl>>CCc1nc2c(C)cc(C)nc2n1-c1ccc(CCCl)cc1,,Cc1ccccc1,,,,val
US20030087952A1,CN1C(=O)C[C@H](c2ccccc2)[C@@H]1[C@H](O)c1ccc(Br)s1.OB(O)c1ccc(F)c(Cl)c1>>CN1C(=O)C[C@H](c2ccccc2)[C@@H]1[C@H](O)c1ccc(-c2ccc(F)c(Cl)c2)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20100041714A1,CC(C)(C)OC(=O)COc1cccc2c1CCC[C@H]2N.O=S(=O)(Cl)c1ccc(F)c(Cl)c1>>CC(C)(C)OC(=O)COc1cccc2c1CCC[C@H]2NS(=O)(=O)c1ccc(F)c(Cl)c1,CN(C)c1ccncc1,C1CCOC1,,Cl,,val
US20030162772A1,CC(=O)Nc1ccccc1O.Cc1ccc(S(=O)(=O)OC[C@@]2(C)CO2)cc1>>CC(=O)Nc1ccccc1OC[C@@]1(C)CO1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05565440,C=CC(=O)OC.COc1ccccc1S>>COc1ccccc1SCCC(=O)O,,CCOCC,CO,[Na+].[OH-],,val
US20090082359A1,COc1cc(-c2ccc(C(F)(F)F)cn2)ccn1>>O=c1cc(-c2ccc(C(F)(F)F)cn2)cc[nH]1,,Cl,,,,val
US20120101136A1,BrCCBr.Cc1cc(O)ccc1-c1noc(-c2ccc(OC(C)C)c(Cl)c2)n1>>Cc1cc(OCCBr)ccc1-c1noc(-c2ccc(OC(C)C)c(Cl)c2)n1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060252768A1,COc1cc(F)ccc1C1CNCCN1.Cn1c(Cl)nc(-c2ccncc2)cc1=O>>COc1cc(F)ccc1C1CN(c2nc(-c3ccncc3)cc(=O)n2C)CCN1,,CN(C)C=O,,CCN(CC)CC,,val
US20160106754A1,COc1ccc2c(c1)SC1=C(CC(C)N(NC(C)=O)C1=O)N2>>COc1ccc2c(c1)SC1=C(CC(C)N(N)C1=O)N2,,CO,,Cl,,val
US20110028448A1,CCOC(=O)c1cnc(N(CC)CC)c(Cl)c1.CC[Zn]CC>>CCOC(=O)c1cnc(N(CC)CC)c(CC)c1,,C1COCCO1,Cc1ccccc1,,,val
US20160145218A1,CC[C@H](N[S@@](=O)C(C)(C)C)c1ccc(OC(F)(F)F)cc1.Cl>>CC[C@H](N)c1ccc(OC(F)(F)F)cc1.Cl,,CO,,,,val
US04304770,CCCCCCNC(=S)SC.[N-]=[N+]=[N-]>>CCCCCCn1nnnc1S,,CCO,,O,,val
US20100273795A1,C1CNCCN1.Cc1cc(C)cc(Oc2ccc(C#N)cc2S(=O)(=O)Cl)c1>>Cc1cc(C)cc(Oc2ccc(C#N)cc2S(=O)(=O)N2CCNCC2)c1,,ClCCl,,,,val
US20150141396A1,CCOC(=O)C1CCC(OS(C)(=O)=O)CC1.Cn1cc(-c2cccc(-c3ncc(-c4cn[nH]c4)cn3)c2)cn1>>CCOC(=O)C1CCC(n2cc(-c3cnc(-c4cccc(-c5cnn(C)c5)c4)nc3)cn2)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110288097A1,CC(C)(O)C1(NC(=O)c2c[nH]c3ncc(C4CC4)nc23)CCNC1.Cl>>CC(C)(O)C1(NC(=O)c2c[nH]c3ncc(C4CC4)nc23)CCNC1.Cl,,CO,,,,val
US05541229,CCCCc1nc2c(C#N)cccc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCCc1nc2c(C#N)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120115868A1,COC(=O)c1sc(CC(O)c2c(C)nnn2-c2ccc(F)cc2)nc1C>>Cc1nc(/C=C/c2c(C)nnn2-c2ccc(F)cc2)sc1C(=O)O,,O=S(=O)(O)O,,,,val
US20100323994A1,N[C@H]1CCCN(Cc2ccccc2)C1.O=C(Nc1ccncc1)c1cnc2c(Nc3ccccn3)cc(Cl)nn12>>O=C(Nc1ccncc1)c1cnc2c(Nc3ccccn3)cc(N[C@H]3CCCN(Cc4ccccc4)C3)nn12,O=C(O)C(F)(F)F,CO,,,,val
US20100144745A1,C#CC[Si](C)(C)C.Nc1ncc(Br)nc1Br>>C[Si](C)(C)CC#Cc1nc(Br)cnc1N,[Cu]I,C1CCOC1,CCOC(C)=O,,,val
US20110034440A1,CN.Fc1ccccc1CBr>>NCCc1ccccc1F,,C1CCOC1,CCOC(C)=O,,,val
US20130225524A1,C=C(C)B1OC(C)(C)C(C)(C)O1.Nc1cc(Br)cc(C(=O)O)c1>>C=C(C)c1cc(N)cc(C(=O)O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20080234344A1,CCOC(=O)CCNC(=O)CCCc1ccccc1>>O=C(O)CCNC(=O)CCCc1ccccc1,,CCO,O,[Na+].[OH-],,val
US04781921,CC1CO1.CCO.CCOCC.NCCN>>CC(O)CNCCNCC(C)O,,CCO,CCOCC,,,val
US20130165472A1,C[Si](C)(C)CCOCn1c(Br)nc(Br)c1Br.OB(O)c1ccccc1Cl>>C[Si](C)(C)CCOCn1c(-c2ccccc2Cl)nc(Br)c1Br,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070043072A1,COC(=O)/C=C/c1cc(C)cc(NC(C)=O)n1>>COC(=O)CCc1cc(C)cc(NC(C)=O)n1,[Pd],CCOC(C)=O,,,,val
US20150225427A1,Cc1ccc(-n2nc([Si](C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)cc1.Nc1cccc(OCCN2CCOCC2)c1>>Cc1ccc(-n2nc([Si](C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4cccc(OCCN5CCOCC5)c4)n3)c3ccccc23)cc1,,CN(C)C=O,,,,val
US20110098299A1,O=C1CCCC2(CCN(c3cccc(Cl)c3)C2=O)C1.[NH4+]>>CN1CCC2(CCCC(N)C2)C1=O,,CO,,[BH3-]C#N.[Na+],,val
US20100181533A1,C#Cc1ccc(C2CCC(C3CCC(CCC)CC3)CC2)cc1.CI>>CC#Cc1ccc(C2CCC(C3CCC(CCC)CC3)CC2)cc1,,C1CCOC1,O,Cl,[Li]CCCC,val
US20030064991A1,BrCCCBr.Cc1[nH]c2ccc(O)cc2c1C(=O)OCc1ccccc1>>[Br-].c1ccc2[nH]ccc2c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160263122A1,CC1CN(C)CCN1.O=C(CCl)Nc1cc(C(=O)Nc2ccc(-c3ccccc3F)nc2)ccc1OC(F)(F)F>>CC1CN(C)CCN1CC(=O)Nc1cc(C(=O)Nc2ccc(-c3ccccc3F)nc2)ccc1OC(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,[I-].[K+],val
US20090036450A1,CC(=O)CC(=O)OC(C)(C)C.CCOC(=O)C(Cl)=NO>>CCOC(=O)c1noc(C)c1C(=O)OC(C)(C)C,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20040267017A1,COc1ccncc1C#N.S>>COc1ccncc1C(N)=S,,CCO,,CCN(CC)CC,,val
US20040102460A1,CNC.FC(F)(F)c1nc(Cl)c2[nH]cnc2n1>>CN(C)c1nc(C(F)(F)F)nc2nc[nH]c12,,C1CCOC1,,CCN(CC)CC,CN(C)C=O,val
US20030130305A1,C=CCBr.CCOC(=O)c1ccc(O)c(C=O)c1>>C=CCOc1ccc(C(=O)OCC)cc1C=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150158855A1,COc1ccc(C[C@@H]2COCC(=O)N2)cc1I.c1cn[nH]c1>>COc1ccc(C[C@@H]2COCC(=O)N2)cc1-n1cccn1,Cl[Cu],CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US20110118248A1,COCN(c1cc(Cl)ccc1C(=O)c1ccnc2c1ccn2[Si](C)(C)C(C)(C)C)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>O=C(c1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1)c1ccnc2[nH]ccc12,,C1COCCO1,Cl,CO,O,val
US20110152273A1,CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.COC(=O)c1c(C)nc(Cl)nc1Nc1cccc(C)c1>>COC(=O)c1c(C)nc(N[C@@H]2CCCC[C@@H]2NC(=O)OC(C)(C)C)nc1Nc1cccc(C)c1,,CC(=O)N(C)C,CCOC(C)=O,CCN(CC)CC,,val
US20060241302A1,CSCCN.Fc1ccc(F)c(C(Sc2ccc(Cl)cc2)c2cc(Cl)ncc2Cl)c1>>CSCCNc1cc(C(Sc2ccc(Cl)cc2)c2cc(F)ccc2F)c(Cl)cn1,,C1COCCO1,,,,val
US20100292225A1,CC1(C)OB(c2cncc(C=O)c2)OC1(C)C.CCOc1cc(Br)ccc1C#N>>CCOc1cc(-c2cncc(C=O)c2)ccc1C#N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(C=O)ccc21.CC(C)(CN)CO>>CC(C)(CO)CNCc1ccc2c(c1)cc(-c1ccc(Cl)c3c1C(=O)NC3)n2C(=O)OC(C)(C)C,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04213998,ClC(Cl)Cl.O.Oc1ccccc1-c1ccccc1>>O=Cc1cc(-c2ccccc2)ccc1O,,O,,CCO,[Na+].[OH-],val
US20040214841A1,C=O.CC(C)Oc1cc(OC2CCNCC2)c2c(Nc3c(Cl)ccc4c3OCO4)ncnc2c1>>CC(C)Oc1cc(OC2CCN(C)CC2)c2c(Nc3c(Cl)ccc4c3OCO4)ncnc2c1,,CO,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US07115608B2,Cc1cc(C)cc(Sc2cc(=O)[nH]c(C)c2CO)c1.O=S(Cl)Cl>>Cc1cc(C)cc(Sc2cc(=O)[nH]c(C)c2CCl)c1,,ClCCl,,,,val
US20100290992A1,CC#Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c2c(=O)n(COC(=O)C(C)(C)C)c(N=CN(C)C)nc12.COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1>>CC#Cc1cn([C@H]2C[C@H](O)[C@@H](COC(c3ccccc3)(c3ccc(OC)cc3)c3ccc(OC)cc3)O2)c2c(=O)n(COC(=O)C(C)(C)C)c(N=CN(C)C)nc12,,c1ccncc1,,ClCCl,,val
US04912108,Nc1ccc2c(Br)cccc2c1N.O=C(O)C(=O)O>>Oc1nc2ccc3c(Br)cccc3c2nc1O,,Cl,,O,O,val
US20100331320A1,C=C[Mg]Br.CON(C)C(=O)c1cccc(F)c1>>CC(=O)c1cccc(F)c1,,C1CCOC1,,,,val
US20060142388A1,CCOC(=O)[C@@]1(F)[C@@H]2C[C@@H](N)[C@@](NC(=O)OC(C)(C)C)(C(=O)OCC)[C@@H]21.O=C(Cl)c1ccc(Cl)c(Cl)c1>>CCOC(=O)[C@@]1(F)[C@@H]2C[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)[C@@](NC(=O)OC(C)(C)C)(C(=O)OCC)[C@@H]21,,ClC(Cl)Cl,,c1ccncc1,,val
US20120289710A1,COc1ccc(CN2C(=O)CC[C@H]2Cc2ccc(-c3ccccc3)cc2)cc1.Cc1ccccc1.O=C(Cl)c1ccccc1>>O=C(c1ccccc1)[C@@H]1CC(Cc2ccc(-c3ccccc3)cc2)N(/C=C/c2ccccc2)C1=O,,[Cl-],[NH4+],[H-].[Na+],,val
US06518257B1,CC(C)C(O)(c1ccc(Br)cc1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.OB(O)c1ccc(Cl)cc1>>CC(C)C(O)(c1ccc(-c2ccc(Cl)cc2)cc1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20040067984A1,OC1(c2ccc(-c3ccccc3)cc2)CCCCC1>>C1=C(c2ccc(-c3ccccc3)cc2)CCCC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080161328A1,Cc1nc2cccc([N+](=O)[O-])c2c(=O)n1[C@]1(C)CCC(=O)NC1=O>>Cc1nc2cccc(N)c2c(=O)n1[C@]1(C)CCC(=O)NC1=O,[Pd],CCOC(C)=O,CO,,,val
US06037340,Cc1c(C(=O)OCc2ccccc2)sc(NC(=O)C(F)(F)F)c1C(=O)OC(C)(C)C>>Cc1c(C(=O)OCc2ccccc2)sc(NC(=O)C(F)(F)F)c1C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160024009A1,C1CCNC1.N#Cc1cc(Cl)nc(Cl)c1>>N#Cc1cc(Cl)nc(N2CCCC2)c1,,CCO,,,,val
US20090197884A1,C=CCO[C@@H]1CN(C2CCOCC2)C[C@H]1NC(=O)Cc1nc2c(C(F)(F)F)cccc2[nH]1>>CCCO[C@@H]1CN(C2CCOCC2)C[C@H]1NC(=O)Cc1nc2c(C(F)(F)F)cccc2[nH]1,[Pd],CO,,,,val
US20160008326A1,COC(=O)C1=Cc2cc(Br)c(C)cc2N(Cc2ccc(OC)cc2)CCC1.Cc1ccccc1>>COC(=O)C1=Cc2cc(CC(C)C)c(C)cc2NCCC1,,ClCCCl,,O,O=C(O)C(F)(F)F,val
US20090023729A1,CCI.CCOC(=O)CN1CCC(CNC(=O)OC(C)(C)C)CC1>>CCOC(=O)CN1CCC(CN(CC)C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US04360468,COC(=O)CC1CCCCCCCCCCC1=O>>OCCC1CCCCCCCCCCC1O,,CC(C)O,,O,[BH4-].[Na+],val
US05354866,CC(C)(C)[Si](C)(C)OCCCO.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CC(C)(C)[Si](C)(C)OCCCOC(=O)Oc1ccc([N+](=O)[O-])cc1,,ClCCl,,CN1CCOCC1,,val
US20120010183A1,CC(=O)OO.CC(C)COc1ncc(B(O)O)cc1Cl>>CC(C)COc1ncc(O)cc1Cl,,CC(=O)O,O,,,val
US20040043998A1,CSc1nc2ccnn2c(Cl)c1C#N.NCc1ccco1>>CSc1nc2ccnn2c(NCc2ccco2)c1C#N,,C1CCOC1,,CCN(CC)CC,O,val
US20130303515A1,Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)NN)Cc2ccc(Cl)cc2)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(Cc2ccc(Cl)cc2)Cc2nnc(O)o2)c1,,C1COCCO1,,,,val
US20050239827A1,Nc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)cc1OCc1ccccc1.O=C(O)CCCCC1SCC2NC(=O)NC21>>O=C(CCCCC1SCC2NC(=O)NC21)Nc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)cc1OCc1ccccc1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030144267A1,CC(=O)Nc1ccccc1O.ClC1C=CCC1>>CC(=O)Nc1ccccc1OC1C=CCC1,,CN(C)C=O,,[H-].[Na+],,val
US20060167246A1,COC(=O)c1cc2[nH]c(B3OC(C)(C)C(C)(C)O3)c(C3CCCCC3)c2s1.O=[N+]([O-])c1cccc(Br)c1OCCOC1CCCCO1>>COC(=O)c1cc2[nH]c(-c3cccc([N+](=O)[O-])c3OCCOC3CCCCO3)c(C3CCCCC3)c2s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])O.[Na+],,val
US20150344727A1,CCCCCCCCCCN(C)C.CCOC(=O)OCC.CO>>CCCCCCCCCC[N+](C)(C)CC.CCOC(=O)[O-],,CO,,,,val
US20160264562A1,C1COCCN1.CCOC(=O)[C@@H](C)OC(=O)C1=C(CBr)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br>>CCOC(=O)[C@@H](C)OC(=O)C1=C(CN2CCOCC2)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br,,CC(C)O,,,,val
US20110172187A1,Nc1ccc2c(c1)B(O)OC2.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)c([N+](=O)[O-])c1>>O=[N+]([O-])c1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c([N+](=O)[O-])c1,,ClCCl,,c1ccncc1,,val
US04803269,Cc1cccc2c1Oc1ccccc1N2C(C)c1ccccc1>>Cc1cccc2c1Oc1ccccc1N2,[Pd],CCO,CCOC(C)=O,[H][H],,val
US20050107377A1,Fc1ccc2c(-c3ccc(OC[C@H]4CO4)cc3)noc2c1.N#CC1(c2ccccc2)CCNCC1>>N#CC1(c2ccccc2)CCN(C[C@@H](O)COc2ccc(-c3noc4cc(F)ccc34)cc2)CC1,,CCO,CN(C)C=O,,,val
US05663189,Cc1cc([N+](=O)[O-])c(C)c2c1OCCO2>>Cc1cc(N)c(C)c2c1OCCO2,[Pd],CCO,,[H][H],,val
US20040121964A1,CC(C)(C)OC(=O)c1ccc(F)nc1.CC1(NC(=O)OCc2ccccc2)CCNCC1>>CC1(NC(=O)OCc2ccccc2)CCN(c2ccc(C(=O)OC(C)(C)C)cn2)CC1,,C1COCCO1,,,,val
US05541213,O=C1NC(=O)c2ccccc21.OC(Cc1ccccn1)c1cccc(Cl)n1>>O=C1c2ccccc2C(=O)N1C(Cc1ccccn1)c1cccc(Cl)n1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160272632A1,CC(C)(C)OC(=O)[C@@H]1CC[C@@](CC#N)(n2nc(N)c3c(OCc4ccccc4)nccc32)CO1>>CC(C)(C)OC(=O)[C@@H]1CC[C@@](CC#N)(n2nc(N)c3c(=O)[nH]ccc32)CO1,[Pd],CCOC(C)=O,CO,,,val
US20160108047A1,COc1ccc(B(O)O)cn1.Cc1noc2c(C)cc(N3C(=O)c4nc(Br)n(C(C)C)c4C3c3ccc(Cl)cc3)cc12>>COc1ccc(-c2nc3c(n2C(C)C)C(c2ccc(Cl)cc2)N(c2cc(C)c4onc(C)c4c2)C3=O)cn1,,CCOC(C)=O,CO,,,val
US04927453,CCOC(=O)c1c(COC(C)=O)cccc1S(=O)(=O)NC(C)(C)C>>CCOC(=O)c1c(COC(C)=O)cccc1S(N)(=O)=O,,O=C(O)C(F)(F)F,,,,val
US20120122817A1,CCN1CCC[C@H]1CN.CCOC(=O)C(=CN(C)C)C(=O)c1cc(I)c(F)nc1F>>CCOC(=O)C(=CNC[C@@H]1CCCN1CC)C(=O)c1cc(I)c(F)nc1F,,C1CCOC1,,,,val
US04371694,CCCCN.O=C1c2ccccc2C(=O)c2c1cccc2[N+](=O)[O-]>>CCCCNc1cccc2c1C(=O)c1ccccc1C2=O,,CN(C)C=O,,,,val
US20090029958A1,O=C(O)COCCc1c(Cl)cccc1Cl.OC1CCNCC1>>O=C(COCCc1c(Cl)cccc1Cl)N1CCC(O)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110237553A1,O=C1CC2CC1C1CCCC21.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>O=S(=O)(OC1=CC2CC1C1CCCC21)C(F)(F)F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20080253965A1,Nc1nc(F)nc2nc(Cc3ccc4c(c3)OCO4)[nH]c12.O=C1CCC(=O)N1Cl>>Nc1nc(F)nc2nc(Cc3cc4c(cc3Cl)OCO4)[nH]c12,,CN(C)C=O,,,,val
US05068340,CCCCCCCCCCCCCCCCCNC(=O)OC[C@H](O)CO.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCCCCCCCCCCCCCCNC(=O)OC[C@H](O)COC(c1ccccc1)(c1ccccc1)c1ccccc1,,Cc1ccccc1,,CCN(CC)CC,O,val
US20110256128A1,CC(C)(C)[C@H](c1nc(-c2cc(F)ccc2F)nn1Cc1cccc(F)c1)N(C[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1F)C(=O)[C@@H]1CCCO1>>CC(C)(C)[C@H](c1nc(-c2cc(F)ccc2F)nn1Cc1cccc(F)c1)N(C[C@@H]1CNC[C@@H]1F)C(=O)[C@@H]1CCCO1,[Pd],CCOC(C)=O,,,,val
US06217793B1,CCCCCCCCCCCCC(=O)Oc1ccc(C(=O)O)cc1.Oc1ccc(OCc2ccccc2)cc1>>CCCCCCCCCCCCC(=O)Oc1ccc(C(=O)Oc2ccc(OCc3ccccc3)cc2)cc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20080200461A1,CCN(CC)CCCCN.Cc1cc(C)cc(C=O)c1>>CCN(CC)CCCCNCc1cc(C)cc(C)c1,,CO,O,Cl,[BH4-].[Na+],val
US20140142122A1,BrCCBr.Oc1ccc(Cl)c(F)c1>>Fc1cc(OCCBr)ccc1Cl,,O,,[Na+].[OH-],,val
US20080188484A1,CC(C)(C)OC(=O)N1CCNCC1.ClCCl.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1>>Cl.O=S(=O)(c1ccc(C(F)(F)F)cc1)N1CCNCC1,,ClCCl,,CCN(CC)CC,,val
US04452625,CC(=O)Cl.CC(C)(C)C(O)C(=CC1CCCCC1)n1cncn1>>CC(=O)OC(C(=CC1CCCCC1)n1cncn1)C(C)(C)C,,C1COCCO1,,[H][H],[H-].[Na+],val
US20050192281A1,CC(C)(C)NO.O=CCOc1ccccn1>>CC(C)(C)[N+]([O-])=CCOc1ccccn1,,CO,,Cl,,val
US20120208827A1,O=C(C1CC1)N1CC[C@@H](Cn2c(-c3ccc(Br)cc3)nc3ccccc32)C1.OB(O)c1ccc2cc[nH]c2c1>>O=C(C1CC1)N1CC[C@@H](Cn2c(-c3ccc(-c4ccc5cc[nH]c5c4)cc3)nc3ccccc32)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20150166559A1,CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)CCC1=O.Nc1cc(F)c(O)cc1C=O>>CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3cc(O)c(F)cc3nc2-1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060106027A1,CI.Clc1ccc(-c2n[nH]cc2-c2ccnc(Cl)n2)c(Cl)c1>>Cn1ncc(-c2ccnc(Cl)n2)c1-c1ccc(Cl)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160194328A1,CC(C)N.Nc1ncnc2c1nc(Sc1cc(Cl)cc(Cl)c1)n2CCBr>>CC(C)NCCn1c(Sc2cc(Cl)cc(Cl)c2)nc2c(N)ncnc21,,CN(C)C=O,,,,val
US20140243336A1,CS(=O)(=O)Cl.Nc1cccc(N)n1>>CS(=O)(=O)Nc1cccc(N)n1,,ClCCl,,c1ccncc1,,val
US05093370,c1cc(CCCCOC2CCCCO2)cc(CCCCOC2CCCCO2)c1>>OCCCCc1cccc(CCCCO)c1,,CCO,,CCOC(C)=O,Cl,val
US20140275083A1,Clc1ccc(I)cc1.O=Cc1cc[nH]n1>>O=Cc1ccn(-c2ccc(Cl)cc2)n1,[Cu]I,Cc1ccccc1,O,CN[C@@H]1CCCC[C@H]1NC,O=C([O-])[O-].[K+].[K+],val
US20100048561A1,COc1cccc(C=O)c1[N+](=O)[O-]>>COc1cccc(C=O)c1N,[Fe],CC(=O)O,,CCO,,val
US20120094972A1,Cc1c(-c2ccccc2F)nc2cc(Cl)ccc2c1Cl.c1cc2c(cc1N1CCOCC1)NCC21CCOCC1>>Cc1c(-c2ccccc2F)nc2cc(Cl)ccc2c1N1CC2(CCOCC2)c2ccc(N3CCOCC3)cc21,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20030171413A1,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=C1COc2ccccc21>>CCOC(=O)Cc1coc2ccccc12,,Cc1ccccc1,,,,val
US20120329769A1,Cc1cc(C2(O)COC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)OC(C)(C)C>>Cc1cc(C2=COC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20150133512A1,C1CCOC1.CCOC(=O)Cc1ccc(-c2cccc(-n3nnc(C)c3NC(=O)O[C@H](C)c3ccccc3)c2)cc1>>Cc1nnn(-c2cccc(-c3ccc(C4(C(=O)O)CC4)cc3)c2)c1NC(=O)O[C@H](C)c1ccccc1,,O,,[Li+].[OH-],,val
US20110306588A1,C1=C(c2cccnc2OC2CNC2)CCOC1.O=C(O)c1ccncn1>>O=C(c1ccncn1)N1CC(Oc2ncccc2C2=CCOCC2)C1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,Cl,val
US20080004267A1,C=[N+]=[N-].CC(C)(C)OC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)C=[N+]=[N-],,C1CCOC1,CCOCC,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20090124625A1,CS(=O)(=O)Cl.OCCC#Cc1ccccn1>>C#CCCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20040067945A1,CC(O)C(=O)O.CCCc1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nn12>>CC(O)C(=O)O.CCCc1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nn12,,CCOCC,O,,,val
US20100256363A1,C[C@H](N)c1ccc(Br)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(N=C=O)c1ccc(Br)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20090264450A1,CC(C)(C)OC(=O)N1CCC(C)(C(=O)Nc2cccc(-c3nnn[nH]3)c2)CC1.CC(C)(C)OC(=O)N1CCC(C)(C(=O)O)CC1.Nc1cccc(-c2nnn[nH]2)c1.c1ccncc1>>Cc1c[nH]c2ncnc(N3CCC(C)(C(=O)Nc4cccc(-c5nnn[nH]5)c4)CC3)c12,CN(C)C=O,CC(Cl)Cl,,O=C(Cl)C(=O)Cl,,val
US20020128301A1,COc1ccc(COC(=O)c2ccc(=O)[nH]c2)cc1.OCCBr>>COc1ccc(COC(=O)c2ccc(=O)n(CCO)c2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05972929,CCCCCCCCCCCCCCCCCC(=O)O.Nc1ccccc1C(=O)O>>CCCCCCCCCCCCCCCCCC(=O)Nc1ccccc1C(=O)O,,ClC(Cl)Cl,ClCCl,CCN(CC)CC,CCOC(=O)Cl,val
US04344954,O=C(O)[C@H](O)[C@@H](O)C(=O)O.OC1(c2ccccc2)C(c2ccccc2)SC2=NCCCCN21>>O=C(O)[C@H](O)[C@@H](O)C(=O)O.OC1(c2ccccc2)C(c2ccccc2)SC2=NCCCCN21,,CC(C)=O,,CC(C)O,,val
US20140235628A1,CN(CC1CCNCC1)C(=O)OC(C)(C)C.Cc1c([C@@H]2CO2)ccc2c1COC2=O>>Cc1c([C@@H](O)CN2CCC(CN(C)C(=O)OC(C)(C)C)CC2)ccc2c1COC2=O,,CCO,,,,val
US20130245080A1,CC(C)(C)Oc1cc(N)cc(F)c1.S=C(n1ccnc1)n1ccnc1>>CC(C)(C)Oc1cc(F)cc(N=C=S)c1,,ClCCl,O,,,val
US20030166628A1,BrBr.Cc1cccc2sccc12>>Cc1cccc2scc(Br)c12,,ClCCl,,CC(=O)[O-].[Na+],,val
US20100160335A1,CC1CC(=O)NN=C1c1ccc(O)cc1.COc1ccc(C2=NN(CCCCBr)C(=O)CC2C)c2ccc(C)nc12>>COc1ccc(C2=NN(CCCCOc3ccc(C4=NNC(=O)CC4C)cc3)C(=O)CC2C)c2ccc(C)nc12,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090253699A1,COC(=O)c1ccc(-c2nnc(-c3cccc(N)c3)o2)cc1.Cc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)c1ccc(-c2nnc(-c3cccc(NS(=O)(=O)c4ccc(C)cc4)c3)o2)cc1,,ClCCl,O,,,val
US05208247,CC(=O)OC(C)=O.CCCCCCCCCCCCCCOc1ccc(COC(=O)NCc2ccccn2)cc1>>CCCCCCCCCCCCCCOc1ccc(COC(=O)N(Cc2ccccn2)C(C)=O)cc1,,ClCCl,,CCN(CC)CC,,val
US20060148858A1,CCCC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCC(=O)OCC>>CCCC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO,,C1CCOC1,CCCCCC,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US20040082607A1,CC(=O)O.CC(=O)OC(C)=O.CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2ccccc2)c2cc(C(N)=NO)ccc2c1=O>>CC(=O)O.CC(=O)O.CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2ccccc2)c2cc(C(=N)N)ccc2c1=O,[Pd],CC(=O)O,,,,val
US20130274243A1,CC(C)(NC(=O)OCc1ccccc1)C(=O)Nc1cc(Br)ccc1N>>CC(C)(NC(=O)OCc1ccccc1)c1nc2cc(Br)ccc2[nH]1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070191370A1,Nc1nc(Cl)cc(Cl)n1.OC(c1ccc(F)c(F)c1)C(F)(F)F>>Nc1nc(Cl)cc(OC(c2ccc(F)c(F)c2)C(F)(F)F)n1,,C1CCOC1,,[H-].[Na+],,val
US20090099195A1,CC(C)N1Cc2c(Cl)nc(Cl)nc2C1=O.CCOc1ccc(CC(C)(C)N)cc1>>CCOc1ccc(CC(C)(C)Nc2nc(Cl)nc3c2CN(C(C)C)C3=O)cc1,,ClCCCl,,CCN(C(C)C)C(C)C,,val
US05461161,Cc1ccnc(F)c1[N+](=O)[O-]>>Cc1ccnc(F)c1N,[Pd],CCOC(C)=O,,CC(=O)O,[H][H],val
US20140371201A1,CCCO.Nc1cc(OCC2CC2)ncn1>>CCCOc1cc(N)ncn1,,CCCO,,,,val
US20060167009A1,CC(C)(C)OC(=O)N1CCN(c2ncc(C(F)(F)F)s2)CC1.Cl>>Cl.FC(F)(F)c1cnc(N2CCNCC2)s1,,C1COCCO1,CCOCC,,,val
US20130079323A1,CCOc1nc(Sc2cc(=O)[nH]c(=O)[nH]2)nc2[nH]c(CC)cc12.O=C1CCC(=O)N1Cl>>CCOc1nc(Sc2cc(=O)[nH]c(=O)[nH]2)nc2[nH]c(CC)c(Cl)c12,,CC(=O)O,,O,,val
US20070027318A1,CCCNC(=O)Nc1ccc(Oc2ccnc3cc(O)c(OC)cc23)cc1Cl.OCCBr>>CCCNC(=O)Nc1ccc(Oc2ccnc3cc(OCCO)c(OC)cc23)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090018132A1,C[Mg]Br.C[Si](C)(C)CCOCn1cc2cc(Cl)cc(C=O)c2n1>>CC(O)c1cc(Cl)cc2cn(COCC[Si](C)(C)C)nc12,,C1CCOC1,,,,val
US20070179165A1,CC#N.Cc1cc(C)c(-c2cccc(Br)n2)c(C)c1>>Cc1cc(C)c(-c2cccc(CC#N)n2)c(C)c1,,C1CCOC1,,[Li]CCCC,,val
US20090099155A1,C#CCBr.CC(C)(C)N1CCNC1=O>>C#CCN1CCN(C(C)(C)C)C1=O,,C1CCOC1,,[Li]CCCC,,val
US20060194816A1,CC(C)(C)[Si](C)(C)Cl.CCOC(=O)C(=O)c1ccc(O)cc1O>>CCOC(=O)C(=O)c1ccc(O[Si](C)(C)C(C)(C)C)cc1O,,ClCCl,,CCN(CC)CC,O,val
US04356188,CC(C)C(=O)Cl.COC(=O)C(C)c1cccc2ccccc12>>COC(=O)C(C)c1cccc2c(C(=O)C(C)C)cccc12,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130029987A1,CSc1nc(NC23CC(C2)C3)ncc1C(N)=O.O=S(=O)(c1ccccc1)N1OC1c1ccccc1>>CS(=O)c1nc(NC23CC(C2)C3)ncc1C(N)=O,,ClC(Cl)Cl,,CCOC(C)=O,,val
US20030065179A1,CCCC(=O)O[C@H](C)c1nccc(Cl)n1.O=C1CC2(CCNCC2)Oc2ccc(Cl)cc21>>CCCC(=O)O[C@H](C)c1nccc(N2CCC3(CC2)CC(=O)c2cc(Cl)ccc2O3)n1,,CC(C)O,,CCN(CC)CC,Cl,val
US20150073019A1,CCOC(=O)CC(C)=O.NNc1nc2ccccc2s1>>Cc1cc(=O)n(-c2nc3ccccc3s2)[nH]1,,CC(=O)O,,O,,val
US20110046108A1,CCOC(=O)c1cc(NS(C)(=O)=O)cc(N2CCOCC2)c1>>CS(=O)(=O)Nc1cc(C(=O)O)cc(N2CCOCC2)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20130344030A1,COC(=O)C1(C(C)O)COCCO1.Cc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)C1(C(C)OS(=O)(=O)c2ccc(C)cc2)COCCO1,,c1ccncc1,,,,val
US04886822,COc1ccc(-c2cccnc2)c([N+](=O)[O-])c1>>O=[N+]([O-])c1cc(O)ccc1-c1cccnc1,,Br,,[Na+].[OH-],,val
US20040167127A1,COc1ccc(C(=O)c2cccc(C(F)(F)F)c2F)cc1.NN>>COc1ccc(-c2n[nH]c3c(C(F)(F)F)cccc23)cc1,CN(C)c1ccncc1,,,O,,val
US04098898,CSC(=NCCSCc1[nH]cnc1C)NC#N.NCCO>>Cc1nc[nH]c1CSCCN=C(NC#N)NCCO,,CCO,,,,val
US04971993,CC(C)(C)OC(=O)NCC(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.Cl>>Cl.NCC(=O)N1CCC[C@H]1C(=O)OCc1ccccc1,,C1COCCO1,CCOCC,,,val
US20110053921A1,COC(=O)C(C)(C)N1C(=O)C2(C)COCCN2c2nc(Cl)ncc21>>CC(C)(C(=O)O)N1C(=O)C2(C)COCCN2c2nc(Cl)ncc21,,C1CCOC1,CO,[Na+].[OH-],,val
US20090036492A1,O=Cc1ccc(F)c2ccccc12.Oc1ccc(Cl)cc1Cl>>O=Cc1ccc(Oc2ccc(Cl)cc2Cl)c2ccccc12,,CS(C)=O,,Cl,[H-].[Na+],val
US20060160856A1,CCOP([O-])OCC.Nc1ccccc1I>>CCOP(=O)(OCC)c1ccccc1N,,N,,CC(C)(C)[O-].[K+],,val
US20160083400A1,NCC1(NP(=O)(c2ccccc2)c2ccccc2)CCc2ccccc21>>NCC1(N)CCc2ccccc21,,C1COCCO1,Cl,,,val
US20100130495A1,N=C=N.Nc1ccc(Br)cc1>>N=C(N)Nc1ccc(Br)cc1,,CCO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20130039906A1,CCOC(=O)Cn1cc(-c2cc3c(-c4cccc(F)n4)nn(C4CCCCO4)c3cn2)cn1>>O=C(O)Cn1cc(-c2cc3c(-c4cccc(F)n4)nn(C4CCCCO4)c3cn2)cn1,,C1CCOC1,CO,[Li+].[OH-],,val
US05180728,CC[N+](=O)[O-].Cc1c(C=O)[nH]c2ccccc12>>CC(=Cc1[nH]c2ccccc2c1C)[N+](=O)[O-],,CO,,C,O=C[O-].[NH4+],val
US20120046268A1,CCc1ccccc1C(=O)NC1CNCC(c2ccc(C(F)(F)F)cc2)C1.O=C=Nc1ccncc1>>O=C(NC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)Nc2ccncc2)C1)c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20060293300A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COCC(N)C(=O)O>>COCC(NC(=O)OC(C)(C)C)C(=O)O,,C1COCCO1,O,[Na+].[OH-],,val
US20100292255A1,CC(=O)O[C@@H](C)C(=O)Cl.Nc1ncnc2c1nc(Sc1cc3c(cc1Br)OCO3)n2C1CCNCC1>>CC(=O)O[C@@H](C)C(=O)N1CCC(n2c(Sc3cc4c(cc3Br)OCO4)nc3c(N)ncnc32)CC1,,C1CCOC1,,CO,,val
US20030069291A1,COc1cc(C(N)=O)on1>>COc1cc(C#N)on1,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US20160168165A1,NCCCN1C(=O)S/C(=C\c2ccc(Sc3nc4ccccc4[nH]3)o2)C1=O.O=C1N[C@H]2CS[C@@H](CCCCC(=O)ON3C(=O)CCC3=O)[C@H]2N1>>O=C(CCCC[C@H]1SC[C@H]2NC(=O)N[C@H]21)NCCCN1C(=O)S/C(=C\c2ccc(Sc3nc4ccccc4[nH]3)o2)C1=O,,ClCCl,O=C(O)C(F)(F)F,CCN(CC)CC,O,val
US04239887,Cc1ccc2c(n1)sc1c(Cl)nnnc12.NC(N)=S>>Cc1ccc2c(n1)sc1c(S)nnnc12,,CCO,,,,val
US20090203690A1,C[Si](C)(C)C#Cc1ccc(F)c(C#N)c1>>C#Cc1ccc(F)c(C#N)c1,,C1CCOC1,ClCCl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20070060583A1,COC(=O)c1ccc(F)c([N+](=O)[O-])c1.NCC1CCC(F)(F)CC1>>COC(=O)c1ccc(NCC2CCC(F)(F)CC2)c([N+](=O)[O-])c1,,CCO,,CCN(CC)CC,Cl,val
US20100233116A1,CC(=O)OCc1ccc(C(F)F)o1>>OCc1ccc(C(F)F)o1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20140142098A1,COC(C)(OC)OC.NNc1ncc(Br)nc1Cl>>Cc1nnc2c(Cl)nc(Br)cn12,,O,,,,val
US20020086890A1,CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCNCC2)cc1.O=C(Cl)N1CCCC1>>CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCN(C(=O)N3CCCC3)CC2)cc1,,ClC(Cl)Cl,,CCN(CC)CC,CN(C)c1ccccn1,val
US20130345206A1,BrCc1ccccc1.O=C1NCCCn2nc(OCc3ccccc3)cc21>>O=C1c2cc(OCc3ccccc3)nn2CCCN1Cc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20030069257A1,CCOC(=O)C=C(CC(OCC)OCC)OCC.NNc1nccs1>>CCOC(=O)Cc1ccnn1-c1nccs1,,CC(=O)O,,,,val
US20120220552A1,CCCCCCCCOc1ccc(C2CN(CCOP(=O)(OC(C)(C)C)OC(C)(C)C)CCO2)cc1.O=C(O)C(F)(F)F>>CCCCCCCCOc1ccc(C2CN(CCOP(=O)(O)O)CCO2)cc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20050090559A1,COc1ccc(F)cc1C(C)(C)CC(O)(C=O)C(F)(F)F.Cc1ncc2c(N)cccc2n1>>COc1ccc(F)cc1C(C)(C)CC(O)(C=Nc1cccc2nc(C)ncc12)C(F)(F)F,,CC(Cl)Cl,,,,val
US20110136875A1,CCOC(=O)CCc1ccn(-c2ccc(-n3ccnc3)cc2)c1-c1ccc(C(N)=O)cc1C>>Cc1cc(C(N)=O)ccc1-c1c(CCC(=O)O)ccn1-c1ccc(-n2ccnc2)cc1,,CO,O,,,val
US20030153752A1,CC(C)(C)OC(=O)N1CCC(n2cc(I)c3c(Cl)ncnc32)CC1>>Clc1ncnc2c1c(I)cn2C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050261350A1,CCCCCN1C(=O)C(C)(C)c2cc3[nH]c(CO)nc3cc21.O=S(Cl)Cl>>CCCCCN1C(=O)C(C)(C)c2cc3[nH]c(CCl)nc3cc21,,ClC(Cl)Cl,,,,val
US20120295875A1,CCOC(=O)C(Br)c1ccccc1.OB1OCc2ccc(O)cc21>>CCOC(=O)C(Oc1ccc2c(c1)B(O)OC2)c1ccccc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US05641430,CCC[Si]1(c2ccccc2)CCC([C@@H]2CC[C@@H](CBr)CC2)CC1.Oc1ccc(OC(F)(F)F)cc1>>CCC[Si]1(c2ccccc2)CCC([C@@H]2CC[C@@H](COc3ccc(OC(F)(F)F)cc3)CC2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070254866A1,CCOC(=O)C(=CNc1cc(F)c(F)c(F)c1)C(=O)OCC>>CCOC(=O)c1cnc2cc(F)c(F)c(F)c2c1O,,c1ccc(Oc2ccccc2)cc1,,,,val
USRE033024,COc1ccc(CC(C)N)cc1.ClCCl.O=C(CBr)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12>>COc1ccc(CC(C)NCC(=O)c2ccc(OCc3ccccc3)c3[nH]c(=O)ccc23)cc1.Cl,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20050065167A1,CCI.O=C(O)Cc1c(F)cc(F)cc1F>>CCOC(=O)Cc1c(F)cc(F)cc1F,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110009454A1,NCc1ccc(Oc2cccc(F)c2)cc1.Nc1nc(F)ccc1C(=O)O>>Nc1nc(F)ccc1C(=O)NCc1ccc(Oc2cccc(F)c2)cc1,,CN(C)C=O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20110105474A1,CC(=O)Cl.CC(C)(C)OC(=O)N1CCNC(c2ccccc2)C1>>CC(=O)N1CCN(C(=O)OC(C)(C)C)CC1c1ccccc1,,ClCCl,,,,val
US20060122256A1,COC(=O)c1cccc(COc2ccc(I)cc2)c1.OB(O)c1cccc2ccccc12>>O=C(O)c1cccc(COc2ccc(-c3cccc4ccccc34)cc2)c1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20100087429A1,CC(C)(C)C#Cc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2>>CC(C)(C)CCc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2,[Pd],CCO,,,,val
US20080090834A1,Ic1ccc(-c2nc(-c3ccccn3)cn2-c2cccnc2)cc1.c1ccc2[nH]ccc2c1>>c1ccc(-c2cn(-c3cccnc3)c(-c3ccc(-n4ccc5ccccc54)cc3)n2)nc1,[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US06921821B2,CCOC(=O)N1CCC(Nc2cc(=O)n(C)c3ccc(OC)cc23)CC1>>COc1ccc2c(c1)c(NC1CCNCC1)cc(=O)n2C,,Br,CC(=O)O,,,val
US05750531,CCc1cc(N2CCc3ccccc3C2)nc(Cl)n1.CNc1ccccc1>>CCc1cc(N2CCc3ccccc3C2)nc(N(C)c2ccccc2)n1.Cl,,CN(C)C=O,,,,val
US20100160303A1,Fc1c(I)ccnc1I.O=C1NCc2ccccc21>>O=C1c2ccccc2CN1c1nccc(I)c1F,[Cu]I,C1COCCO1,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US20050054655A1,CC(=O)N1CCN(c2cc(C)c(N)c(N)c2)CC1.CC(=O)N1CCN(c2cc(C)c(N)c([N+](=O)[O-])c2)CC1>>CC(=O)Nc1c(C)cc(-n2ccnc2)cc1[N+](=O)[O-],[Pd],CC(=O)O,,CO,[H][H],val
US20060014664A1,CSc1ccccc1.O=C(Cl)C1CCC1>>CSc1ccc(C(=O)C2CCC2)cc1,,CC(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20070287701A1,N#C[C@H]1CN(Cc2ccccc2)C[C@H]1C(N)=O>>NC[C@@H]1CN(Cc2ccccc2)C[C@@H]1C(N)=O,,CO,,,,val
US20090076147A1,CC(C)C(=O)Cl.CCOC(=O)OCCOC(=O)[C@H](O)C(C)(C)COS(=O)(=O)CCCCl>>CCOC(=O)OCCOC(=O)[C@H](OC(=O)C(C)C)C(C)(C)COS(=O)(=O)CCCCl,,ClCCl,,c1ccncc1,,val
US20110224225A1,COC(=O)C(C#N)C(C)c1ccc(N2CCN(C)CC2)cc1>>CC(CC#N)c1ccc(N2CCN(C)CC2)cc1,,O,,CS(C)=O,[Cl-].[Na+],val
US20080045493A1,C=C(C)c1ccc(S(=O)(=O)Nc2ccc([C@@H]3CCN(CCC)C3)cc2)c(F)c1>>CCCN1CC[C@@H](c2ccc(NS(=O)(=O)c3ccc(C(C)C)cc3F)cc2)C1,[Pd],CO,,,,val
US20160052898A1,O=C(CN1CCOCC1)Nc1cc(NC(=O)c2ccc(Br)cc2)ccc1OC(F)(F)F.OB(O)c1ccc(F)cc1>>O=C(CN1CCOCC1)Nc1cc(NC(=O)c2ccc(-c3ccc(F)cc3)cc2)ccc1OC(F)(F)F,,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20150126449A1,COc1cccc2nn3c(=O)cc(C4CCN(C(=O)OC(C)(C)C)CC4)[nH]c3c12.Cl>>COc1cccc2nn3c(C4CCNCC4)cc(=O)[nH]c3c12.Cl,,C1COCCO1,,CO,,val
US20050215626A1,BrC(Br)(Br)Br.COC(=O)c1ccc(OCCO)c(Cl)c1>>COC(=O)c1ccc(OCCBr)c(Cl)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130172556A1,CNN=C(C)CS(C)(=O)=O.Cn1cc(C(=O)C(=O)Cl)c2ccccc21>>CC(CS(C)(=O)=O)=NN(C)C(=O)C(=O)c1cn(C)c2ccccc12,,O,,C1CCOC1,,val
US05874440,CCC(=O)OC(=O)CC.CCCOc1ccccc1-c1nc(N)cc(=O)[nH]1>>CCCOc1ccccc1-c1nc(NC(=O)CC)cc(=O)[nH]1,,CCO,,O,,val
US05736545,Fc1ccc2oc(S)nc2c1.O=P(Cl)(Cl)Cl>>Fc1ccc2oc(Cl)nc2c1,,ClCCl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20090054466A1,CCOC(=O)/C=C/c1c(C=CCCCCO[Si](C)(C)C(C)(C)C)cccc1OCCCC(=O)OCC>>CCOC(=O)CCCOc1cccc(CCCCCCO[Si](C)(C)C(C)(C)C)c1CCC(=O)OCC,[Pd],CCOC(C)=O,,[H][H],,val
US05773433,O=C1Nc2ccccc2Oc2cc(Cl)ccc21>>Clc1ccc2c(c1)Oc1ccccc1NC2,,C1CCOC1,C1COCCO1,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20060019995A1,CC1CC(=O)C=C(c2cccs2)N1C(=O)OC(C)(C)C>>CC1CC(=O)C=C(c2cccs2)N1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20140243310A1,O=C(CCl)N1CCOCC1.OC1CCc2oc(-c3ccc(OCC4CC4)c(Cl)c3)nc2C1>>O=C(COC1CCc2oc(-c3ccc(OCC4CC4)c(Cl)c3)nc2C1)N1CCOCC1,,C1CCOC1,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US05464855,CC(C)Oc1c(C(=O)O)sc2c1CN(C(=O)OC(C)(C)C)CC2.Nc1nnn[nH]1>>CC(C)Oc1c(C(=O)Nc2nnn[nH]2)sc2c1CN(C(=O)OC(C)(C)C)CC2,,CN(C)C=O,,O,O=C(n1ccnc1)n1ccnc1,val
US20090082351A1,CNc1ccccc1.Cc1cc(Oc2ccnc(Cl)n2)c(C)cc1N>>Cc1cc(Oc2ccnc(N(C)c3ccccc3)n2)c(C)cc1N,,Cl,,CCOC(C)=O,,val
US20050043309A1,COc1c(Cl)cccc1N1CCN(C(=O)OC(C)(C)C)CC1>>COc1c(Cl)cccc1N1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04820729,CCOC(=O)CN(C(=O)[C@H](C)NC(=O)OCc1ccccc1)c1ccc2c(c1)CCC2>>C[C@H](NC(=O)OCc1ccccc1)C(=O)N(CC(=O)O)c1ccc2c(c1)CCC2,,CCO,,[Na+].[OH-],,val
US20090054425A1,CC(=O)N1CCN(c2ccc(N)cc2)CC1.Cc1ccc(S(=O)(=O)n2cc(C)c3c(Nc4ccc5cn[nH]c5c4)nc(Cl)nc32)cc1>>CC(=O)N1CCN(c2ccc(Nc3nc(Nc4ccc5cn[nH]c5c4)c4c(C)cn(S(=O)(=O)c5ccc(C)cc5)c4n3)cc2)CC1,,CCCCO,,C[Si](C)(C)Cl,,val
US20050130989A1,CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.FC(F)Oc1cccc(N2CCNCC2)c1.On1nnc2ccccc21>>Cc1cc(C(=O)N2CCN(c3cccc(OC(F)F)c3)CC2)n(-c2ccccc2)n1.Cl,,ClCCl,,Cl,O,val
US04421753,CSC(=NC#N)SC.Fc1ccc(CN2CCNCC2)cc1>>CSC(=NC#N)N1CCN(Cc2ccc(F)cc2)CC1,,CCO,,,,val
US20090118259A1,NCCn1cnc2cc(C(=O)N3C4CCC3CC(O)C4)ccc21.O=C(Cl)N1CCS(=O)(=O)CC1>>O=C(NCCn1cnc2cc(C(=O)N3C4CCC3CC(O)C4)ccc21)N1CCS(=O)(=O)CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US06589967B1,CC(=NO)c1cc(C)cc(C)n1.COc1ccc(CCl)c(OC)c1>>COc1ccc(CON=C(C)c2cc(C)cc(C)n2)c(OC)c1,,CN(C)C=O,,[H-].[Na+],,val
US20100222270A1,CCOC(=O)C=Cc1cc2cnc(Cl)cc2n1CC(=O)OC(C)(C)C>>CCOC(=O)CCc1cc2cnc(Cl)cc2n1CC(=O)OC(C)(C)C,O=[Pt]=O,CCOC(C)=O,,,,val
US03932375,CC(=O)CC(C)=O.Cl.NC(N)=S>>Cc1cc(C)nc(S)n1.Cl,,CCO,,,,val
US20030078251A1,CC(=O)Cl.COc1cc(CCC(=O)O)cc(NC(=O)C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)CO)C2=O)c1OC>>COc1cc(CCC(=O)O)cc(NC(=O)C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)COC(C)=O)C2=O)c1OC,,O,,CCOC(C)=O,c1ccncc1,val
US20160272655A1,CNc1ccc(OCOC)c(Cl)n1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COCOc1ccc(N(C)C(=O)C(F)(F)F)nc1Cl,,Cl,ClCCl,CCN(C(C)C)C(C)C,,val
US20120225854A1,CC(C)(C)OC(=O)N1CCN[C@@H](CN(c2ccccc2)S(C)(=O)=O)C1.OC(c1cnc(Cl)nc1)(C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCN(c2ncc(C(O)(C(F)(F)F)C(F)(F)F)cn2)[C@@H](CN(c2ccccc2)S(C)(=O)=O)C1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20080103183A1,CNC(C)(C#N)c1ccccc1>>CNC(CN)c1ccccc1,,Cc1ccccc1,,CC(C)C[AlH]CC(C)C,,val
US04001222,CC(C)(C)OC(=O)NCCC(=O)O.Cl.N#Cc1ccc(-c2ccc(C=NN3CC(=O)NC3=O)o2)cc1>>Cl.N#Cc1ccc(-c2ccc(C=NN3CC(=O)N(C(=O)CCN)C3=O)o2)cc1,,CN(C)C=O,,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20130303509A1,CNN.O=C(C#CC1CC1)c1ccc([N+](=O)[O-])cc1>>Cn1nc(C2CC2)cc1-c1ccc([N+](=O)[O-])cc1,,CN(C)C=O,O,,,val
US20100160308A1,BrCCN1CCOCC1.NC(=O)c1sc(-n2cnc3ccc(O)cc32)nc1-c1cccc(Cl)c1>>NC(=O)c1sc(-n2cnc3ccc(OCCN4CCOCC4)cc32)nc1-c1cccc(Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090099175A1,CCc1cc(C(C)=O)c(N)cc1OC.O=N[O-]>>CCc1cc2c(O)cnnc2cc1OC,,Cl,O,O=C([O-])O.[Na+],,val
US20090215803A1,CC(C)CCOc1ccccc1Br.CCOB(OCC)OCC>>CC(C)CCOc1ccccc1B(O)O,,C1CCOC1,,[Li]CCCC,,val
US20090143396A1,CC1CN(Cc2ccc(OC(F)(F)F)cc2)CC(C)N1.COC(=O)Cc1cc(S(=O)(=O)Cl)ccc1C>>COC(=O)Cc1cc(S(=O)(=O)N2C(C)CN(Cc3ccc(OC(F)(F)F)cc3)CC2C)ccc1C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110009584A1,CCCCCCCCCCCCOc1cc(C(=O)NN)cc(OCCCCCCCCCCCC)c1OCCCCCCCCCCCC.COC(=O)c1ccc(C(=O)Cl)cc1>>CCCCCCCCCCCCOc1cc(C(=O)NNC(=O)c2ccc(C(=O)OC)cc2)cc(OCCCCCCCCCCCC)c1OCCCCCCCCCCCC,,C1CCOC1,,O,c1ccncc1,val
US04643991,S=C(Cl)Cl.Sc1nnnn1-c1ccccc1>>S=C(Cl)Sc1nnnn1-c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20090286765A1,CC(C)(C)OC(=O)N1CCCCC1/C=N\S(=O)C(C)(C)C.CCSc1cccc([Mg]Br)c1>>CCSc1cccc(C(N)C2CCCCN2C(=O)OC(C)(C)C)c1,,C1CCOC1,,,,val
US20160038504A1,Cc1ncc(N)cc1-c1cc(N2CCOCC2)c2nccn2n1.O=C(O)c1ccc(CBr)c(C(F)(F)F)c1.On1nnc2cccnc21>>Cc1ncc(NC(=O)c2ccc(CBr)c(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c2nccn2c1,,CN(C)C=O,O,CCN=C=NCCCN(C)C,Cl,val
US20150198876A1,O=C([O-])C1(C(F)(F)F)CC2C=CC1C2.c1ccc([S+](c2ccccc2)c2ccccc2)cc1>>O=C([O-])C1(C(F)(F)F)CC2C=CC1C2.c1ccc([S+](c2ccccc2)c2ccccc2)cc1,,ClCCl,,[Cl-].[Na+],,val
US20100021423A1,CCOC(=O)c1ccc(NC2CC2)cc1>>O=C(O)c1ccc(NC2CC2)cc1,,CCO,,[Na+].[OH-],,val
US20150274718A1,COC(=O)C(OC(C)(C)C)c1c(C(F)(F)F)ccc(-c2ccncc2)c1-c1ccc2c(c1)CCCO2>>CC(C)(C)OC(C(=O)O)c1c(C(F)(F)F)ccc(-c2ccncc2)c1-c1ccc2c(c1)CCCO2,,C1COCCO1,O,[Li+].[OH-],,val
US20110009465A1,CCC(O)[C@H]1CCN(C(=O)OC(C)(C)C)C1>>CC[C@H](O)[C@H]1CCN(C(=O)OC(C)(C)C)C1,,CC(=O)O,O,,,val
US20160152599A1,Cc1cc(C(=O)N(c2ccccc2)c2ccc(OCc3ccccc3)cc2)cn1-c1ccccc1C(=O)N1Cc2ccccc2C[C@H]1CN(C)C>>Cc1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)cn1-c1ccccc1C(=O)N1Cc2ccccc2C[C@H]1CN(C)C,[Pd],CCO,,C1=CCCCC1,,val
US20020052346A1,CC(C)(C)OC(=O)c1cccc(I)c1.Cc1ccc(B(O)O)cc1>>Cc1ccc(-c2cccc(C(=O)OC(C)(C)C)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20090196912A1,Nc1cccnc1.O=Cc1cccc(O)c1>>Oc1cccc(CNc2cccnc2)c1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070111981A1,CC(C)(C)OC(=O)NCCCc1ccc(NCc2ccccc2)nn1>>NCCCc1ccc(NCc2ccccc2)nn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070082907A1,CCOC(=O)C(C)(C)Oc1ccc(Oc2cc(I)cc(C#N)c2)cc1C.C[Sn](C)(C)C>>CCOC(=O)C(C)(C)Oc1ccc(Oc2cc(C)cc(C#N)c2)cc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20120196894A1,CI.OC[C@@H]1CC[C@@H](Nc2ccc(F)cc2)[C@@]2(O)CCCO[C@H]12>>COC[C@@H]1CC[C@@H](Nc2ccc(F)cc2)[C@]2(O)CCCO[C@H]12,,C1CCOC1,O,[H-].[Na+],[Cl-].[NH4+],val
US20150080364A1,C1COCCN1.Cc1ccc(C(=O)O)c(CN2CCN(C(=O)OC(C)(C)C)CC2)c1>>Cc1ccc(C(=O)N2CCOCC2)c(CN2CCN(C(=O)OC(C)(C)C)CC2)c1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20030236252A1,CN.O=C1CCC(c2ccc3[nH]c(=O)oc3c2)CC1>>CN[C@@H]1CC[C@@H](c2ccc3[nH]c(=O)oc3c2)CC1,,C1CCOC1,,CO,[BH4-].[Na+],val
US20040023995A1,Cc1cc(=O)c2c(=O)n(CCCC[C@@H](C)N=[N+]=[N-])c(=O)n(C)c2n1Cc1ccccc1>>Cc1cc(=O)c2c(=O)n(CCCC[C@@H](C)N)c(=O)n(C)c2n1Cc1ccccc1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140235620A1,CC(=O)c1nccc(Oc2ccc(F)cc2)n1>>CC(O)c1nccc(Oc2ccc(F)cc2)n1,,ClCCl,,CO,[BH4-].[Na+],val
US20090069420A1,CCOC(=O)c1ccc(NC(=O)CC(CNS(=O)(=O)c2ccc(C)cc2)c2ccccc2)cc1>>Cc1ccc(S(=O)(=O)NCC(CC(=O)Nc2ccc(C(=O)O)cc2)c2ccccc2)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20030050330A1,C1CCOC1.CO.Cc1csc(-c2cccc(C(=O)C(O)c3ccc(F)cc3)c2-c2ccccc2)c1.O=S([O-])OO>>CS(=O)(=O)c1ccc(-c2cccc(C(=O)C(O)c3ccc(F)cc3)c2-c2ccccc2)cc1,,ClCCl,,O,,val
US20060240048A1,CC1(C)OC(=O)c2cnc(Nc3cccc(Cl)c3)cc21.NCC1CCOCC1>>CC(C)(O)c1cc(Nc2cccc(Cl)c2)ncc1C(=O)NCC1CCOCC1,,CCCCCC,ClCCl,C[Al](C)C,,val
US20160083413A1,CC(C)(C)C(=O)SCCO.O=P(Cl)(Cl)Cl>>CC(C)(C)C(=O)SCCOP(=O)(Cl)Cl,,ClCCl,,CCN(CC)CC,,val
US20100120798A1,Clc1ncnc2[nH]ccc12.NCC1(C(=O)Nc2ccc(C(F)(F)F)cn2)CCNCC1>>NCC1(C(=O)Nc2ccc(C(F)(F)F)cn2)CCN(c2ncnc3[nH]ccc23)CC1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20150336949A1,COc1nc(N2CCNCC2)ccc1-c1cnc2c(c1)c(-c1cnn(Cc3cccc(F)c3)c1)cn2S(=O)(=O)c1ccc(C)cc1.C[C@H]1CO1>>COc1nc(N2CCN(C[C@H](C)O)CC2)ccc1-c1cnc2c(c1)c(-c1cnn(Cc3cccc(F)c3)c1)cn2S(=O)(=O)c1ccc(C)cc1,,CCO,,CCN(C(C)C)C(C)C,,val
US05130119,CC1(C)OCC(O)C(NC(=O)c2ccc(S(=O)(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc2)CO1>>O=C(NC(CO)C(O)CO)c1ccc(S(=O)(=O)Nc2ccc(F)c(C(F)(F)F)c2)cc1,,O,,CCO,,val
US20130172331A1,N#Cc1ncc(O)cc1Cl.OCC(F)F>>N#Cc1ncc(OCC(F)F)cc1Cl,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030158177A1,CC(=O)N1CCCCc2ccc(C(=O)CCCl)cc21.CNC>>CC(=O)N1CCCCc2ccc(C(=O)CCN(C)C)cc21,,ClCCl,,,,val
US06107297,COC(=O)CS.COC(=O)Cc1ccc(-c2cnc(Cl)nc2Cl)cc1>>COC(=O)CSc1nc(Cl)ncc1-c1ccc(CC(=O)OC)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20110166121A1,CO.COc1ccc(CSC[C@H](N)C(=O)O)cc1>>COC(=O)[C@@H](N)CSCc1ccc(OC)cc1,,CCOC(C)=O,CO,C[Si](C)(C)Cl,,val
US20120289526A1,CC(C)Oc1cccc(Oc2ccc(NC(=O)[C@@H](C)N)cn2)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)Oc1cccc(Oc2ccc(N3C(=O)N[C@H](C)C3=O)cn2)c1,,ClCCl,,CCN(CC)CC,,val
US06936602B1,COC(=O)C1=Cc2cc(Br)ccc2N(C=O)CC1.[O-]B([O-])Oc1ccc(N2CCOCC2)cc1>>COC(=O)C1=Cc2cc(-c3ccc(N4CCOCC4)cc3)ccc2N(C=O)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O,O=C([O-])[O-].[K+].[K+],val
US20110034512A1,O=C(Cl)C(=O)Cl.O=C(O)c1cccc2c1cnn2-c1ccc(F)cc1>>O=C(Cl)c1cccc2c1cnn2-c1ccc(F)cc1,,ClCCl,,CN(C)C=O,,val
US20050153987A1,CN(CCN1CCCC1)S(=O)(=O)c1ccc(Cl)nc1.N#Cc1ccc2c(c1)CC(=O)N2>>CN(CCN1CCCC1)S(=O)(=O)c1ccc(-c2c(O)[nH]c3ccc(C#N)cc23)nc1.Cl,,CN(C)C=O,,[H-].[Na+],,val
US20080306122A1,COC(=O)[C@H](CC#Cc1ccc(Br)cc1)NC(=O)OC(C)(C)C>>COC(=O)[C@@H](N)CC#Cc1ccc(Br)cc1,,CCOC(C)=O,CO,CC(=O)Cl,,val
US20100216814A1,CN(C)C=O.CN1CCc2[nH]c3ccc(Cl)cc3c2C1.Cc1cnccn1.O=C(O)[C@@H]1CCCN1>>C/C(=C\n1c2c(c3cc(Cl)ccc31)CN(C)CC2)c1cnc(C)cn1,[Cu]I,,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20160039828A1,CCOC(=O)c1nc2cccnn2c1Br.NC1CC1>>O=C(NC1CC1)c1nc2cccnn2c1Br,,CO,,[Ca+2].[Cl-].[Cl-],,val
US04220647,CC(C)N(CC1NCCc2ccc(O)c(O)c21)C(=O)OCc1ccccc1.Cl.Cl>>CC(C)NCC1NCCc2ccc(O)c(O)c21.Cl.Cl,,CC(=O)O,,,,val
US03950353,CN=C=O.Cc1nc[nH]c1CSCCN>>CNC(=O)NCCSCc1[nH]cnc1C,,CC#N,,,,val
US20120157449A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CC=O)CC1.c1cc(C2CCNCC2)c2ccoc2c1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CCN2CCCCC2c2ccoc3cccc2-3)CC1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20060166964A1,COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(F)(C(=O)OC)Cc1ccccc1-3>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(F)(C(=O)O)Cc1ccccc1-3,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20050026935A1,Clc1ncnc2scc(Br)c12.NCc1ccccn1>>Brc1csc2ncnc(NCc3ccccn3)c12,,O,,CCN(CC)CC,CCO,val
US20090131472A1,C[Si](C)(C)C#CC(=O)C(c1cccc(-c2ccc(F)cc2F)n1)c1c(F)cc(C#N)cc1F>>C#CC(=O)C(c1cccc(-c2ccc(F)cc2F)n1)c1c(F)cc(C#N)cc1F,,C1CCOC1,CCOC(C)=O,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20120129870A1,N#Cc1cc([N+](=O)[O-])ccc1N1CCN(C(c2ccccc2)c2ccccc2)CC1>>N#Cc1cc(N)ccc1N1CCN(C(c2ccccc2)c2ccccc2)CC1,[Zn],CC(C)=O,O,[Cl-].[NH4+],,val
US20080027067A1,O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C1CNCCN1c1ccccc1>>O=C1CN(C(=O)C(F)(F)F)CCN1c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20030004181A1,CCCCCCCCOC(=O)Cl.CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C)c1ccccc1>>CCCCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccc4)ccc3n2C)cc1,,CCO,ClCCl,Cl,,val
US20090312388A1,CCOC(=O)Cc1ccc(N2C(=O)c3c(c(OCC(F)(F)F)c4ccccc4c3OCC)C2O)c(Cl)c1.CCOC(=O)Cc1ccc(N2C(=O)c3c(c(OCC)c4ccccc4c3OCC(F)(F)F)C2O)c(Cl)c1>>CCOC(=O)Cc1ccc(N2Cc3c(c(OCC(F)(F)F)c4ccccc4c3OCC)C2=O)c(Cl)c1.CCOC(=O)Cc1ccc(N2Cc3c(c(OCC)c4ccccc4c3OCC(F)(F)F)C2=O)c(Cl)c1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20140235855A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CC(=O)O)OC1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CCO)OC1,,C1CCOC1,,CO,,val
US20040176385A1,CC(=O)O.CCC(CC)(C(=O)[O-])C(=O)[O-].O=Cc1cccc(C=O)c1>>CCOC(=O)C(=Cc1cccc(C=O)c1)C(=O)OCC,,Cc1ccccc1,,C1CCNCC1,,val
US20050038248A1,COc1ccc(NS(=O)(=O)c2ccccc2N)cc1.O=S(=O)(Cl)c1cccs1>>COc1ccc(NS(=O)(=O)c2ccccc2NS(=O)(=O)c2cccs2)cc1,,ClCCl,,CCN(CC)CC,,val
US20150126485A1,COc1ccc(Cn2c(C)cnc2-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)cc1>>Cc1cnc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)[nH]1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20070128204A1,CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1.COc1ccc(C[C@H](Nc2cccc(-c3ccccc3)c2)C(=O)O)cc1OC>>COc1ccc(C[C@H](Nc2cccc(-c3ccccc3)c2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)cc1OC,,CO,ClCCl,,,val
US05912244,CC(C)(C)[Si](C)(C)Cl.CC1=Cc2cc(Sc3ccc(O)cc3)ccc2OC1(C)C>>CC1=Cc2cc(Sc3ccc(O[Si](C)(C)C(C)(C)C)cc3)ccc2OC1(C)C,,CN(C)C=O,,c1c[nH]cn1,,val
US20120220550A1,CCOC(=O)CC(=O)c1cccc(C(F)(F)F)c1.NNc1ccccn1>>Oc1cc(-c2cccc(C(F)(F)F)c2)nn1-c1ccccn1,,CCO,,,,val
US20070032517A1,CC(=O)Nc1c(C(C)O)c(=O)n(C)c2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc12>>Cn1c(=O)cc(N)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc21,,CCOC(C)=O,,C1COCCO1,Cl,val
US20070053831A1,CC(=O)c1cc2ccc(N(C)CCO)cc2oc1=O.N#CCC#N>>CC(=C(C#N)C#N)c1cc2ccc(N(C)CCO)cc2oc1=O,,c1ccncc1,,,,val
US20050038068A1,C=CCOc1cccc(-c2csc3[nH]c(=O)c(C#N)c(O)c23)c1>>N#Cc1c(O)c2c(-c3cccc(O)c3)csc2[nH]c1=O,,ClCCl,,ClB(Cl)Cl,,val
US20110053924A1,COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)[C@@H](CC(=O)NNC(=O)OC(C)(C)C)C[C@@H]3c3ccc(COC[C@@H](C)COC)cc3)cc21>>COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)[C@@H](CC(=O)NN)C[C@@H]3c3ccc(COC[C@@H](C)COC)cc3)cc21,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20150322002A1,NS(N)(=O)=O.O=C(O)c1cc(Cl)c(Oc2ccc(OC(F)(F)F)c(Cl)c2)cc1F>>NS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(OC(F)(F)F)c(Cl)c2)cc1F,,C1CCOC1,CCOC(C)=O,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20160152621A1,CC(C)C(=O)Cl.O=C(O)[C@@H]1CCCCN1>>CC(C)C(=O)N1CCCC[C@H]1C(=O)O,,C1COCCO1,O,CCN(CC)CC,,val
US20070197478A1,CCOC(=O)N(Cc1ccccc1)c1cc(Br)nc(N)c1[N+](=O)[O-].CN>>CCOC(=O)N(Cc1ccccc1)c1cc(NC)nc(N)c1[N+](=O)[O-],,C1CCOC1,,,,val
US20080249079A1,CC(C)c1cc(Nc2cc(Cl)nc(Cl)n2)n[nH]1.NCc1cc(-c2ccccc2)no1>>CC(C)c1cc(Nc2cc(Cl)nc(NCc3cc(-c4ccccc4)no3)n2)n[nH]1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20020052355A1,CN1C2CCC1CC(=O)C2.Clc1ccc(Br)cc1>>CN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2,,CCOCC,,[Li]CCCC,,val
US20160229872A1,COc1cccc(-c2nsc3c(=O)n(CC4(O)CCN(C(=O)C5CC5)CC4)cnc23)c1>>O=C(C1CC1)N1CCC(O)(Cn2cnc3c(-c4cccc(O)c4)nsc3c2=O)CC1,,ClCCl,,BrB(Br)Br,,val
US20100024683A1,C=C(C)C(=O)Cl.Nc1ccc(O)cc1>>C=C(C)C(=O)Nc1ccc(O)cc1,,CC(=O)N(C)C,,,,val
US20080166359A1,CC(C)(C)OC(=O)N1CCCC[C@H]1C1(O)CN(C(=O)c2ccncc2Nc2ccc(I)cc2F)C1.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)N1CCCC[C@H]1C1(O)CN(C(=O)c2cc[n+]([O-])cc2Nc2ccc(I)cc2F)C1,,ClCCl,,,,val
US20100292230A1,O=C(Cl)CCCCl.O=C(NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1)c1ccc(Cl)s1>>O=C(CCCCl)N(C[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1)C(=O)c1ccc(Cl)s1,,CCOC(C)=O,O,CN(C)C=O,[H-].[Na+],val
US20060229336A1,COC(=O)c1cccc(N)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1cccc(N(S(=O)(=O)C(F)(F)F)S(=O)(=O)C(F)(F)F)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US03973006,C=[N+]=[N-].CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O>>CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)OC,,CO,,CC(=O)O,,val
US04329353,O=C(O)C1(c2ccc(F)cc2)CCC2(CC1)OCCO2>>O=C1CCC(C(=O)O)(c2ccc(F)cc2)CC1,,CC(=O)O,,Cl,,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccco2)c1C#N.Cc1cccc(C)c1NCCN>>Cc1cccc(C)c1NCCNc1nc(N)nc(-c2ccco2)c1C#N,,COCCOC,,,,val
US04258187,CN=C=O.Nc1ccc(Cl)cc1C(=O)c1ccccc1>>CN1C(=O)Nc2ccc(Cl)cc2C1(O)c1ccccc1,,ClCCl,,,,val
US06333336B1,Cc1[nH]cc2c(=O)n(-c3ccc(Cl)cc3)nc-2c1-c1ccc(N)cc1.O=Cc1ccccn1>>Cc1[nH]cc2c(=O)n(-c3ccc(Cl)cc3)nc-2c1-c1ccc(NCc2ccccn2)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20140135311A1,CCOC(=O)C1CCN(C(=O)OC(C)(C)C)CCC1=O.CI.NC(N)=S>>CSc1nc(O)c2c(n1)CCN(C(=O)OC(C)(C)C)CC2,,CCO,,C,C[O-].[Na+],val
US20080214511A1,CCOC(=O)CCc1cn(CC(=O)OC(C)(C)C)c2cccc(N)c12>>O=C(O)Cn1cc2c3c(cccc31)NC(=O)CC2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140206680A1,CC(C)(C)OC(=O)N[C@H]1COCC[C@H]1Nc1nc(Cl)c2c(c1F)CN(C(=O)OC(C)(C)C)C2=O.CCCC[Sn](CCCC)(CCCC)c1cc2c(s1)c(C)nn2C>>Cc1nn(C)c2cc(-c3nc(N[C@@H]4CCOC[C@@H]4NC(=O)OC(C)(C)C)c(F)c4c3C(=O)N(C(=O)OC(C)(C)C)C4)sc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20090221583A1,CO.ClCCl.O=Cc1ccc(C(=O)O)cc1>>C#Cc1ccc(C(=O)OC)cc1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20090306082A1,COc1cccc2c1OCC2=O.N#CCC(=O)O>>COc1cccc2c(CC#N)coc12,,Cc1ccccc1C,,C,O=C[O-].[NH4+],val
US20030105087A1,O=C1Cc2cc(Br)cnc2N1>>Brc1cnc2[nH]ccc2c1,,C1CCOC1,,,,val
US04940710,C=O.CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(CF)C3)c(F)c21>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(C)C(CF)C3)c(F)c21,,O=CO,,CC(=O)[O-].[Na+],,val
US20160264548A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)C1.N#CBr.NC(=O)c1cc(Cl)cnc1Oc1ccc(Oc2ccccc2)cc1>>N#CN1CCC(c2cnc(Oc3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2)C1,[Pd],CO,,Cl,,val
US20130231328A1,CI.COC(=O)C1CCC(O[Si](C)(C)C(C)(C)C)CC1>>COC(=O)C1(C)CCC(O[Si](C)(C)C(C)(C)C)CC1,,C1CCOC1,,[Li]CCCC,,val
US20060257987A1,CC(=O)OCCC(C)OS(=O)(=O)c1ccc(C)cc1.O=C(c1ccccc1)c1cc2ccccc2cc1O>>CC(=O)OCCC(C)Oc1cc2ccccc2cc1C(=O)c1ccccc1,,CCOCC,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080021032A1,CC(C)(C)OC(=O)Nc1cccc(CBr)c1.O=[N+]([O-])c1cc[nH]n1>>CC(C)(C)OC(=O)Nc1cccc(Cn2ccc([N+](=O)[O-])n2)c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US04818765,O=C(O)CCl.Oc1ccc(C(=C2SCCCS2)c2ccccc2)cc1>>O=C(O)COc1ccc(C(=C2SCCCS2)c2ccccc2)cc1,,O,,Cl,[Na+].[OH-],val
US20160095858A1,CC(C)(C)c1ccc(C#N)c(Cl)n1.CNc1ccccc1C>>Cc1ccccc1N(C)c1nc(C(C)(C)C)ccc1C#N,,C1COCCO1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20140205537A1,CN(C)C=O.CN(C)S(=O)(=O)n1ccnc1C(C)(C)C>>CN(C)S(=O)(=O)n1c(C=O)cnc1C(C)(C)C,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20080312272A1,CC(N)(C#N)Cn1nc2ccc(Cl)cc2n1.O=C(Cl)c1ccc(OC(F)(F)F)cc1>>CC(C#N)(Cn1nc2ccc(Cl)cc2n1)NC(=O)c1ccc(OC(F)(F)F)cc1,,ClCCl,,,,val
US20060252812A1,O=C1N(CCC2CC2)c2ccccc2C1(O)c1cc2c(cc1O)OCO2>>O=C1C(c2cc3c(cc2O)OCO3)c2ccccc2N1CCC1CC1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US06956050B2,CC(C)(C)[Si](C)(C)Cl.OCCc1ccc(-n2cnc(-c3ccccc3)c2)cc1>>CC(C)(C)[Si](C)(C)OCCc1ccc(-n2cnc(-c3ccccc3)c2)cc1,,ClCCl,,c1c[nH]cn1,,val
US20050107377A1,Fc1ccc(OC2CCNCC2)cc1.Fc1ccc2c(-c3ccc(OC[C@@H]4CO4)cc3)noc2c1>>O[C@H](COc1ccc(-c2noc3cc(F)ccc23)cc1)CN1CCC(Oc2ccc(F)cc2)CC1,,CCO,CN(C)C=O,,,val
US04342825,COC(=O)c1ccc(O)cc1.FC(F)=C(F)C(F)(F)F>>COC(=O)c1ccc(OC(F)(F)C(F)C(F)(F)F)cc1,,CC(C)=O,,[K+].[OH-],,val
US20020099047A1,CN(C)c1ccc(CCN2CC[C@@H](N3c4ccccc4COc4ccccc43)C2)cc1.Cl.ClCCl>>CN(C)c1ccc(CCN2CC[C@@H](N3c4ccccc4COc4ccccc43)C2)cc1.Cl.Cl,,ClCCl,,CCOC(C)=O,,val
US20030195354A1,CI.COc1ccc(CCNC(=O)C(=COC(F)F)c2ccc3c(c2)CCCC3)cc1OC>>COc1ccc(CCN(C)C(=O)C(=COC(F)F)c2ccc3c(c2)CCCC3)cc1OC,,O,,CN(C)C=O,[H-].[Na+],val
US20060004003A1,CCn1ncc2c(-c3cncc(C)c3)c(C(=O)OC(C)(C)C)c(COC)nc21>>CCn1ncc2c(-c3cncc(C)c3)c(CO)c(COC)nc21,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20160200704A1,ON=Cc1ccc2[nH]ccc2c1F>>NCc1ccc2[nH]ccc2c1F,[Ni],CO,N,,,val
US20140228343A1,CC(C)(C)OC(=O)N1CCc2cn[nH]c2C1.CI>>Cn1ncc2c1CN(C(=O)OC(C)(C)C)CC2,,CN(C)C=O,,[H-].[Na+],,val
US20060025474A1,CCCCCCC(C)(C)C(=O)OCC>>CCCCCCC(C)(C)CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150051190A1,CN.ClCc1cccc(Cl)c1>>CNCc1cccc(Cl)c1,,CN(C)C=O,,O,,val
US20150329542A1,COc1cc(CC(F)(F)F)c(-c2cc3[nH]nc(I)c3cn2)cc1F.C[Si](C)(C)CCOCCl>>COc1cc(CC(F)(F)F)c(-c2cc3c(cn2)c(I)nn3COCC[Si](C)(C)C)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US20100256156A1,CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2cc(-c3ccc(F)cc3)oc2C)C2CCCCC2)cn1>>Cc1oc(-c2ccc(F)cc2)cc1C(Nc1ccc(C(=O)N(C)CCC(=O)O)nc1)C1CCCCC1,,CCO,,C1CCOC1,[Li+].[OH-],val
US05599829,CCI.Cc1cccc(C)c1NC(=S)NCC(N)=O>>CCSC1=NCC(=O)N1c1c(C)cccc1C,,CCO,,,,val
US20020026060A1,CC1(C)CCSc2ccc(CC(=O)O)cc21.CCCCCI>>CCCCCC(C(=O)O)c1ccc2c(c1)C(C)(C)CCS2,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US04886800,CCCc1c(C)[nH]c2ccccc12.CO.O>>CCCC(=O)c1ccccc1NC(C)=O,,CO,,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20150329523A1,CI.COc1cc(N)cc([N+](=O)[O-])c1>>CNc1cc(OC)cc([N+](=O)[O-])c1,,CN(C)C=O,,[H-].[Na+],,val
US20040224952A1,CC1CCCN1CCC#Cc1cc(Br)ccc1N>>CC1CCCN1CCc1cc2cc(Br)ccc2[nH]1,,CN1CCCC1=O,,CC(C)(C)O[K],,val
US05045228,CCCCCCCCCCCCBr.O=C(O)c1ccc(O)c(Cl)c1>>CCCCCCCCCCCCOc1ccc(C(=O)O)cc1Cl,,O,,CCO,[Na+].[OH-],val
US20150175540A1,COC(=O)[C@@H]1CC[C@@H](CN2Cc3ccc(OC)c(F)c3C2=O)CC1>>COc1ccc2c(c1F)C(=O)N(C[C@@H]1CC[C@@H](C(=O)O)CC1)C2,,CO,,[Na+].[OH-],,val
US20100130494A1,O=C(Cl)OCc1ccccc1.O=C1CCNc2ccccc21>>O=C1CCN(C(=O)OCc2ccccc2)c2ccccc21,,C1CCOC1,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US20160207887A1,CC(=O)CC(C)=O.Cc1cc(CBr)cc(C)c1Br>>CC(=O)CCc1cc(C)c(Br)c(C)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US04122179,CC[C@@]12C=C(C(=O)OC)n3c4c(c5ccccc53)CCN(CCC1)[C@H]42.O=C(O)COc1ccc(Cl)cc1>>CC[C@@]12C=C(C(=O)OC)n3c4c(c5ccccc53)CCN(CCC1)[C@H]42.O=C([O-])COc1ccc(Cl)cc1,,O,,,,val
US05096890,C=Cc1ccccn1.NC(=O)C(c1ccccc1)(c1ccccc1)C1CCNC1>>NC(=O)C(c1ccccc1)(c1ccccc1)C1CCN(CCc2ccccn2)C1,,C1COCCO1,,,,val
US20100113462A1,CCOC(=O)C1(NC(=O)c2ccccc2-c2ccccc2)Cc2ccccc2C1>>O=C(NC1(C(=O)O)Cc2ccccc2C1)c1ccccc1-c1ccccc1,,CCO,,O,[K+].[OH-],val
US20010056094A1,CCOc1cccc(-c2ccc(C(C(=O)OC)C(=O)OC)c([N+](=O)[O-])c2)c1>>CCOc1cccc(-c2ccc(CC(=O)O)c([N+](=O)[O-])c2)c1,,Cl,,,,val
US20060199796A1,O=C(O)c1cc(F)ccc1[N+](=O)[O-].Oc1ccc(F)cc1F>>O=C(O)c1cc(Oc2ccc(F)cc2F)ccc1[N+](=O)[O-],,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20060172988A1,Cc1cc(F)ccc1C(CN)CCOC1CCCCO1.N#Cc1cc2c(c(C(=O)O)c1)CCCC2>>Cc1cc(F)ccc1C(CCOC1CCCCO1)CNC(=O)c1cc(C#N)cc2c1CCCC2,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US06392089B1,CC(C)(C)O.O=C(CO)c1ccccc1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)OCC(=O)c1ccccc1,,C1CCOC1,O,CC(C)(C)[O-].[K+],,val
US20080176864A1,CC(=O)NN.CN(C)C=O.Cc1c(N2CCC[C@H]2C(=O)O)ccc(C#N)c1Cl>>CC(=O)NNC(=O)CC1CCCN1c1ccc(C#N)c(Cl)c1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20100004246A1,CC(=O)Nc1cccc(-n2nc(Br)c(=O)n(Cc3ccc(Cl)cc3)c2=O)c1.CNC>>CC(=O)Nc1cccc(-n2nc(N(C)C)c(=O)n(Cc3ccc(Cl)cc3)c2=O)c1,,CN(C)C=O,,CO,,val
US04053601,COC(=O)CCC(=O)c1cc(C(=O)OC)ccc1OCC(O)CNC(C)(C)C>>CC(C)(C)NCC(O)COc1ccc(C(=O)O)cc1C(=O)CCC(=O)O,,CC(=O)O,,[Na+].[OH-],,val
US20120058893A1,COC(=O)c1scnc1N.O=S(=O)(Cl)Cc1ccccc1I>>COC(=O)c1scnc1NS(=O)(=O)Cc1ccccc1I,,C1COCCO1,,CCN(CC)CC,O,val
US20080275090A1,CC(C)(C)c1ccc(N)cc1.CC(C)(C)c1ccccc1Oc1ncccc1N=C=S>>CC(C)(C)c1ccc(NC(=S)Nc2cccnc2Oc2ccccc2C(C)(C)C)cc1,,ClCCCl,,,,val
US20060241302A1,COc1ccc(-n2ccnc2C(OC(=O)OC(C)(C)C)c2cc(F)ccc2F)cc1.Sc1ccc(Cl)cc1>>COc1ccc(-n2ccnc2C(Sc2ccc(Cl)cc2)c2cc(F)ccc2F)cc1,,CCOCC,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20110195948A1,Nc1cnn2ccc(N3CCC[C@@H]3c3cccc(F)c3)nc12.O=C(O)c1cccnc1>>O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cccc(F)c3)nc12)c1cccnc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100256156A1,COC(=O)c1cc(Br)oc1CBr.C[S-]>>COC(=O)c1cc(Br)oc1CSC,,C1CCOC1,,O,,val
US20120129856A1,c1cc2c(s1)CCNC2>>c1cc2c(s1)CCNC2,,O,,Cl,[Na+].[OH-],val
US20090186879A1,CCC(OC(C)=O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl>>CCC(O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl,,CO,,O=C([O-])[O-].[K+].[K+],,val
US06248739B1,CC(C)(C)OC(=O)Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(C#CCO)ccc21>>O=C(O)Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(C#CCO)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120214803A1,CC(C)(C)S(=O)NCc1ccc2cccnc2c1[N+](=O)[O-].Cl>>Cl.NCc1ccc2cccnc2c1[N+](=O)[O-],,CO,,C1COCCO1,,val
US20060074102A1,COC(=O)c1cc2c(-c3cccc(-c4ccccc4)c3)cncc2o1>>O=C(O)c1cc2c(-c3cccc(-c4ccccc4)c3)cncc2o1,,CO,,[K+].[OH-],,val
US20160229816A1,N#Cc1[nH]nnc1-c1ccc(CO)cc1.O=S(Cl)Cl>>N#Cc1[nH]nnc1-c1ccc(CCl)cc1,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US20140171388A1,CCCCCCCCCCCCCCCBr.O=C(CO)c1ccccc1>>CCCCCCCCCCCCCCCOc1ccccc1C(C)=O,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20100305145A1,CCOC(=O)[C@@H](C)CC(Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)c1nnn(Cc2ccc(OC)cc2)n1>>CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)c1nn[nH]n1,,O=C(O)C(F)(F)F,,,,val
US09108923B2,CN(C)CCO.COc1cc(/C=C/C(=O)N2CCC=CC2=O)cc(OC)c1OC>>C=C(C)C(=O)NC(=O)/C=C/C,,C1CCOC1,Cc1ccccc1,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110218193A1,COCn1c(=O)c2cccnc2c2cc(CCCO)ccc21>>COCn1c(=O)c2cccnc2c2cc(CCC=O)ccc21,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20040058903A1,CC(C)(C)OC(=O)Nc1nc(CCNC(=O)c2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)cs1>>Nc1nc(CCNC(=O)c2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)cs1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110059951A1,COCC1CN(C(=O)c2ccc(C#N)cc2F)CCN1CC(CC#N)n1cc(-c2ncnc3c2ccn3COCC[Si](C)(C)C)cn1>>COCC1CN(C(=O)c2ccc(C#N)cc2F)CCN1CC(CC#N)n1cc(-c2ncnc3[nH]ccc23)cn1,,O=C(O)C(F)(F)F,,ClCCl,,val
US20080113978A1,CCC(CC)c1cc(C)nn2c(-c3sc(Br)c(Br)c3C)c(C)nc12>>CCC(CC)c1cc(C)nn2c(-c3scc(Br)c3C)c(C)nc12,,C1CCOC1,,[Li]CCCC,,val
US20070155808A1,CCCC(=O)c1ccc(O)cc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCCC(=O)c1ccc(OS(=O)(=O)C(F)(F)F)cc1,,O,c1ccncc1,,,val
US04003914,COc1ccc(CCN(C)CCCCl)cc1OC.O=S1(=O)CCCS(=O)(=O)C1c1ccc2c(c1)OCO2>>CNCCCC1(c2ccc3c(c2)OCO3)S(=O)(=O)CCCS1(=O)=O.Cl,,CN(C)C=O,,[H-].[Na+],,val
US20160002259A1,COc1c(C2CO2)ccc(C#N)c1F>>COc1c(CCO)ccc(C#N)c1F,[Pd],CCO,,O=C[O-].[NH4+],,val
US20120077781A1,CI.COC(=O)CCCCCCn1c2nc(=O)[nH]c(=O)c-2nc2cc(C)c(C)cc21>>COC(=O)CCCCCCn1c2nc(=O)n(C)c(=O)c-2nc2cc(C)c(C)cc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06689769B2,CC(=O)NC[C@H]1CN(c2ccc(N)c(F)c2)C(=O)O1.CCOC(=O)C(=CN(C)C)C(=O)c1cc(F)c(F)cc1F>>CCOC(=O)/C(=C\Nc1ccc(N2CC(CNC(C)=O)OC2=O)cc1F)C(=O)c1cc(F)c(F)cc1F,,CCO,,,,val
US04179549,C=C(C)C(=O)OCCN(C)C.C=CC(N)=O>>C=C(C)C(=O)OCCN(C)C.C=CC(N)=O,,O,,CC(=O)O,,val
US20050277676A1,CC(C)(C)[O-].C[C@@H]1CC(=O)C[C@H](C)N1Cc1ccccc1>>C=C1C[C@H](C)N(Cc2ccccc2)[C@H](C)C1,,C1CCOC1,,,,val
US20120135999A1,CCCC[Sn](I)(CCCC)CCCC.N#Cc1cn(C2CCC2)c2cnc(Cl)cc12>>CCCC[Sn](CCCC)(CCCC)c1c(C#N)c2cc(Cl)ncc2n1C1CCC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US05132310,BrBr.c1ccc(-c2cccs2)nc1>>Brc1ccc(-c2ccccn2)s1,,ClCCl,,,,val
US06582351B1,COc1ccc(CBr)cc1OC.O=c1[nH]c2cc(C(F)(F)F)ccc2n1[C@@H]1CC[C@@H](O)CC1>>COc1ccc(Cn2c(=O)n([C@@H]3CC[C@@H](O)CC3)c3ccc(C(F)(F)F)cc32)cc1OC,,CN(C)C=O,,[H-].[Na+],,val
US20160046744A1,CC(=O)C(C)Cl.Oc1ccc(-c2ccc(-c3ccc(OCc4ccccc4)cc3)cc2F)cc1>>CC(=O)C(C)Oc1ccc(-c2ccc(-c3ccc(OCc4ccccc4)cc3)cc2F)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110028442A1,CC(Cc1cccc([N+](=O)[O-])c1)NC(=O)OC(C)(C)C>>CC(Cc1cccc(N)c1)NC(=O)OC(C)(C)C,[Pd],CO,,,,val
US06620817B1,CN(C)C(=O)CN.FC(F)(F)c1ccc(-c2nc(Cl)cc(-c3ccccc3)n2)cc1>>CN(C)C(=O)CNc1cc(-c2ccccc2)nc(-c2ccc(C(F)(F)F)cc2)n1,,ClC(Cl)Cl,,CCN(CC)CC,O,val
US05814648,N[C@@H](CO)c1ccccc1.O=C(Cl)c1cccc(OCc2ccccc2)c1>>O=C(N[C@@H](CO)c1ccccc1)c1cccc(OCc2ccccc2)c1,,ClCCl,,CCN(CC)CC,,val
US20090163489A1,Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc(Br)cn1>>Cc1ccc(S(=O)(=O)N=c2ccc(Br)c[nH]2)cc1,,c1ccncc1,,,,val
US20050137204A1,C#C[Si](C)(C)C.Ic1ccc(OC2CN3CCC2CC3)cc1>>C#Cc1ccc(OC2CN3CCC2CC3)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20150119362A1,CCOC(=O)Cc1ccc(Nc2cc(-c3cccc(Cl)c3)nc(C3CC3)c2)cc1.N>>NC(=O)Cc1ccc(Nc2cc(-c3cccc(Cl)c3)nc(C3CC3)c2)cc1,,CO,,C1COCCO1,,val
US20140107097A1,CON(C)C(=O)c1cncnc1.Clc1ccc([Mg]Br)cc1>>O=C(c1ccc(Cl)cc1)c1cncnc1,,C1CCOC1,,,,val
US04505739,CC(C)(C)C(=O)OC(=O)C(C)(C)C.CC(C)(C)c1cc(N)n[nH]1>>CC(C)(C)C(=O)Nc1cc(C(C)(C)C)[nH]n1,,c1ccccc1,,[Na+].[OH-],,val
US20160022626A1,CC(=O)O[C@@H](C)/C=C\C(=O)N[C@@H]1C[C@H](C)[C@H](C/C=C(C)/C=C/[C@H]2O[C@H](CC(=O)NCCNC(=O)OCc3ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](N)C(C)C)cc3)C[C@@]3(CO3)[C@@H]2O)O[C@@H]1C.O=C(CBr)NCCOCCOCCOCCOCCOCCOCCC(=O)Oc1c(F)c(F)c(F)c(F)c1F>>CC(=O)O[C@@H](C)/C=C\C(=O)N[C@@H]1C[C@H](C)[C@H](C/C=C(C)/C=C/[C@H]2O[C@H](CC(=O)NCCNC(=O)OCc3ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)CBr)C(C)C)cc3)C[C@@]3(CO3)[C@@H]2O)O[C@@H]1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04645765,CC(=O)Oc1cc(C=O)cc2c1C(COC(N)=O)C1(OC(C)=O)ON2CC2C1N2C(C)=O.NO>>CC(=O)Oc1cc(C=NO)cc2c1C(COC(N)=O)C1(OC(C)=O)ON2CC2C1N2C(C)=O,,CO,,Cl,O=C([O-])O.[Na+],val
US20060122168A1,CC[C@@H]1Oc2ccccc2NC(=O)[C@@H]1NC(=O)OC(C)(C)C>>CC[C@@H]1Oc2ccccc2NC(=O)[C@@H]1N,,C1CCOC1,,O=P(O)(O)O,,val
US20100261698A1,C=Cc1c(-c2cncc(NS(=O)(=O)CC)c2)n(C)c2ccccc12>>CCc1c(-c2cncc(NS(=O)(=O)CC)c2)n(C)c2ccccc12,,CO,,,,val
US20030187020A1,CC(C)(C)OC(=O)N(Cc1cccc(C2CCNCC2)c1)C(=O)OC(C)(C)C.O=C(O)c1cncc(C#Cc2ccccc2)c1>>CC(C)(C)OC(=O)N(Cc1cccc(C2CCN(C(=O)c3cncc(C#Cc4ccccc4)c3)CC2)c1)C(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100111900A1,COc1cc(CSC)c(Br)cc1C(C)(C)C.COc1ncccc1B(O)O>>COc1cc(CSC)c(-c2cccnc2OC)cc1C(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,ClCCl,O=C([O-])[O-].[Na+].[Na+],,val
US20070099990A1,COc1c(C)c(NC(=O)CC(C)(C)C)c(C)c2c1OCC2c1ccc(C(C)C)cc1>>Cc1c(O)c2c(c(C)c1NC(=O)CC(C)(C)C)C(c1ccc(C(C)C)cc1)CO2,,CCCCCC,CCOC(C)=O,,,val
US20120184539A1,CC(C)(C)OC(=O)NC(C)(CO)c1cccc(Br)n1.O=S(Cl)Cl>>CC(C)(C)OC(=O)N1S(=O)OCC1(C)c1cccc(Br)n1,,ClCCl,,Cl,c1ccncc1,val
US20030207926A1,COC(=O)Cc1ccc(F)c(NC(=O)CC(C)C)c1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COC(=O)Cc1ccc2sc(CC(C)C)nc2c1,,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20110046416A1,C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1.Cl>>C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1.Cl,,CCOC(C)=O,,,,val
US20130150343A1,C=O.O=C(O)[C@@H]1C[C@@H](F)CN1>>CN1C[C@H](F)C[C@H]1C(=O)O,[Pd],,,Cl,,val
US20050137171A1,O=P(Oc1ccc2[nH]nc(C3Cc4ccccc4N3)c2c1)(c1ccccc1)c1ccccc1>>O=P(Oc1ccc2[nH]nc(-c3cc4ccccc4[nH]3)c2c1)(c1ccccc1)c1ccccc1,,CS(C)=O,,,,val
US20090227541A1,C[N+](=O)[O-].O=Cc1ccccc1B(O)O>>O=[N+]([O-])CC1OB(O)c2ccccc21,,O,,Cl,[Na+].[OH-],val
US20030229130A1,COC(=O)c1ccc(NS(C)(=O)=O)c2occc12>>CS(=O)(=O)Nc1ccc(CO)c2ccoc12,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US05843942,CCN(Cc1ccccc1OCc1ccccc1)c1ccc(C(=O)OC(C)(C)C)c(F)c1>>CCN(Cc1ccccc1OCc1ccccc1)c1ccc(C(=O)O)c(F)c1,,O=CO,,CCOCC,,val
US20140323470A1,CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)n(-c2cn(CCO)cn2)n1.CS(=O)(=O)Cl>>CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)n(-c2cn(CCOS(C)(=O)=O)cn2)n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100317624A1,CCBr.CCOC(=O)c1c[nH]c2cc(Br)ccc2c1=O>>CCOC(=O)c1cn(CC)c2cc(Br)ccc2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040122235A1,CCOC(=O)Cc1csc(NC(=O)Nc2ccc(C)cc2C(=O)C2CCCC2)n1.O=C1CCC(=O)N1Br>>CCOC(=O)C(Br)c1csc(NC(=O)Nc2ccc(C)cc2C(=O)C2CCCC2)n1,,CC#N,ClCCl,,,val
US05688815,O=c1ccn(CCO)c(C(O)c2ccc(Cl)cc2)c1OCc1ccccc1>>O=c1ccn(CCO)c(C(O)c2ccc(Cl)cc2)c1O,,CCOC(C)=O,,Cl,[Na+].[OH-],val
US05840749,CCOC(=O)c1ccccc1COc1ccc(CC(C)(C)C(=O)OCC)cc1>>CC(C)(Cc1ccc(OCc2ccccc2C(=O)O)cc1)C(=O)O,,CCO,O,Cl,[K+].[OH-],val
US20040167128A1,C1CCOC1.CC1=CCCc2ccc(NS(=O)(=O)c3ccccc3F)c(Br)c21>>C[C@H]1c2c(ccc(NS(=O)(=O)c3ccccc3F)c2Br)CC[C@@H]1O,,C1CCOC1,,CCOCC,FB(F)F,val
US20080280875A1,CCOC(=O)c1cc(OC(C)=O)c2cc(C)oc2c1>>CCOC(=O)c1cc(O)c2cc(C)oc2c1,,CCO,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20090030038A1,CCc1cc(Br)ccc1S(=O)(=O)Cl.COc1ccc(N)c2c1C[C@@H](N(C)C)CC2>>CCc1cc(Br)ccc1S(=O)(=O)Nc1ccc(OC)c2c1CC[C@H](N(C)C)C2,,CN1CCCC1=O,,CCN(CC)CC,,val
US20040044053A1,CC(C)(C)OC(=O)NCCN.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)NCCNc1ccc([N+](=O)[O-])cc1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120088750A1,CCNC(=O)Nc1nc2cc(-c3nsc(N4CCC(CC)(C(=O)OCC)CC4)n3)cc(-c3ccccn3)c2s1>>CCNC(=O)Nc1nc2cc(-c3nsc(N4CCC(CC)(C(=O)O)CC4)n3)cc(-c3ccccn3)c2s1,,CCO,,[Na+].[OH-],,val
US20140200344A1,IC[C@@H]1CC[C@@H](c2nnn3cnc4[nH]ccc4c23)CC1.O=S([O-])C(F)(F)F>>O=S(=O)(C[C@@H]1CC[C@@H](c2nnn3cnc4[nH]ccc4c23)CC1)C(F)(F)F,,CN(C)C=O,,O,,val
US20090192150A1,CON(C)C(=O)c1cc(N)cc(S(F)(F)(F)(F)F)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CON(C)C(=O)c1cc(NC(=O)C(F)(F)F)cc(S(F)(F)(F)(F)F)c1,,ClCCl,O,CCN(CC)CC,O=C([O-])O.[Na+],val
US04600709,CCOC(=O)C1Oc2cc(C)c(S(=O)(=O)c3ccccc3)cc2O1.N>>Cc1cc2c(cc1S(=O)(=O)c1ccccc1)OC(C(N)=O)O2,,C1COCCO1,,,,val
US20030216388A1,CC1(C)OC(=O)Nc2ccc(B(O)O)cc21.N#Cc1ccc(Br)cc1F>>CC1(C)OC(=O)Nc2ccc(-c3ccc(C#N)c(F)c3)cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,[Na+].[OH-],,val
US20040157838A1,CC(C)(C)OC(=O)N1CCNCC1.Cc1cc(Cl)n2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)c2n1>>Cc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)n2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)c2n1,,ClCCCl,,CCN(C(C)C)C(C)C,,val
US05281614,CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1F>>CCCCc1nn(-c2cc(N)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1F,,C1CCOC1,Cl,CCOC(C)=O,[Na+].[OH-],val
US20100029611A1,N#Cc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)cc1.O=C([O-])C(O)C(O)C(=O)[O-]>>O=Cc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)cc1,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20150158878A1,N#CBr.Nc1cc2c(cc1N)OC(F)(F)O2>>Br.Nc1nc2cc3c(cc2[nH]1)OC(F)(F)O3,,CO,,,,val
US20130225584A1,BrCc1ccccc1.CC(=O)c1cc(C)c(Br)cc1O>>CC(=O)c1cc(C)c(Br)cc1OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20150315188A1,BrC1CCCC1.Cc1ccc2c(c1)c1c(n2C[C@@H](O)c2ccncc2)CCN2CCC[C@H]12>>Cc1ccc2c(c1)c1c(n2C[C@@H](OC2CCCC2)c2ccncc2)CCN2CCC[C@H]12,,CN(C)C=O,,[H-].[Na+],,val
US20120149694A1,O=C(N1CCOCC1)N1CC(CSc2cccc(F)c2)CC(c2ccc(C(F)(F)F)cc2)C1.O=C(OO)c1cccc(Cl)c1>>O=C(N1CCOCC1)N1CC(CS(=O)c2cccc(F)c2)CC(c2ccc(C(F)(F)F)cc2)C1,,ClCCl,,,,val
US05504104,O=C1CCc2ccc(O)cc21.OCc1ccccc1>>O=C1CCc2ccc(OCc3ccccc3)cc21,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100210619A1,C1CCC(NCC2CC2)CC1.COC(=O)CN(C)S(=O)(=O)c1ccc(NC(=O)c2cc(Cl)ncn2)c(C)c1>>COC(=O)CN(C)S(=O)(=O)c1ccc(NC(=O)c2cc(N(CC3CC3)C3CCCCC3)ncn2)c(C)c1,,CO,,CC(C)NC(C)C,,val
US20160115177A1,O=C(CCl)Nc1ccc(-c2ccccc2)cn1.O=c1c2c([nH]c(=S)n1-c1ccccc1)CCS2>>O=C(CSc1nc2c(c(=O)n1-c1ccccc1)SCC2)Nc1ccc(-c2ccccc2)cn1,,CN(C)C=O,,CCN(CC)CC,,val
US20090156593A1,C1CCNC1.O=C1CCC2(CC1)OCCO2.c1c[nH]nn1>>c1cn(C2(N3CCCC3)CCC3(CC2)OCCO3)nn1,,Cc1ccccc1,,,,val
US20040198751A1,CCOC(=O)c1cnc(SC)nc1Cl.CNN>>CCOC(=O)c1cnc(SC)nc1N(C)N,,CCO,,O,,val
US05023258,CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(O)cc4)CC3)nc2)c1=O.Clc1ccc(C2(Cn3cncn3)CO2)c(Cl)c1>>CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC(O)(Cn5cncn5)c5ccc(Cl)cc5Cl)cc4)CC3)nc2)c1=O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120309769A1,COC(=O)C1(c2ccc(Cn3c(C)c(C)c4cc(C(=O)O)ccc43)cc2)CC1.C[C@H](N)c1cccc(Br)c1>>COC(=O)C1(c2ccc(Cn3c(C)c(C)c4cc(C(=O)N[C@@H](C)c5cccc(Br)c5)ccc43)cc2)CC1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04714698,C1CNCCN1.CCSc1ncnc2c(N3CCCCC3)nc(Cl)nc12>>CCSc1ncnc2c(N3CCCCC3)nc(N3CCNCC3)nc12,,CS(C)=O,,,,val
US20060004017A1,CC(C)(C)OC(=O)N1CCC(CO)CC1.Cc1cc2cc(Oc3ncnc4cc(O)ccc34)ccc2[nH]1>>Cc1cc2cc(Oc3ncnc4cc(OCC5CCCCN5C(=O)OC(C)(C)C)ccc34)ccc2[nH]1,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060183732A1,C=C[C@H](NC1CCCC1)c1ccccc1.O=C(Cl)c1ccccc1>>C=C[C@@H](c1ccccc1)N(Cc1ccccc1)C1CCCC1,,ClCCl,,CC(C)NC(C)C,,val
US20110230461A1,CC(=O)O.COC(=O)Cc1ccc(OC)cc1[N+](=O)[O-]>>COC(=O)Cc1ccc(OC)cc1NC(C)=O,[Zn],CC(=O)O,,CC(=O)OC(C)=O,,val
US06288061B1,CCOC(=O)c1nc(-c2ccc([N+](=O)[O-])cc2)[nH]c1-c1cccc(OC)c1>>COc1cccc(-c2[nH]c(-c3ccc([N+](=O)[O-])cc3)nc2C(=O)O)c1,,CCO,,[Na+].[OH-],,val
US20100087427A1,O=C(Cl)Cc1ccccc1.c1ccc(C[C@H]2CN(Cc3ccccc3)C[C@@H]2CNc2ccccc2)cc1>>O=C(Cc1ccccc1)N(C[C@H]1CN(Cc2ccccc2)C[C@@H]1Cc1ccccc1)c1ccccc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20030216379A1,O=C1CCC(=O)N1Br.c1cnc2c(c1)CCCc1[nH]ncc1-2>>Brc1n[nH]c2c1-c1ncccc1CCC2,,CC(Cl)Cl,ClCCl,CC(=O)[O-].[Na+],,val
US20120202797A1,O=C1Nc2ccc(Cl)cc2Cn2cc(Cl)cc21.O=P(Cl)(Cl)Cl>>ClC1=Nc2ccc(Cl)cc2Cn2cc(Cl)cc21,,ClC(Cl)Cl,,,,val
US06028195,CC(O)=S.COc1cc(OC)cc(N2CCN(C(=O)Nc3cc(C(C)O)c(C)nc3OC)CC2)c1>>COc1cc(OC)cc(N2CCN(C(=O)Nc3cc(C(C)OC(C)=S)c(C)nc3OC)CC2)c1,,C1CCOC1,,,,val
US20060020003A1,CCCCc1oc2ccccc2c1C(=O)Nc1ccc(-c2ccc(OCC#N)cc2)cc1.[N-]=[N+]=[N-]>>CCCCc1oc2ccccc2c1C(=O)Nc1ccc(-c2ccc(OCc3nnn[nH]3)cc2)cc1,,CCOC(C)=O,,[Cl-].[NH4+],,val
US20040034005A1,CN.O=[N+]([O-])c1cc(Cl)ccc1CCBr>>CNCCc1ccc(Cl)cc1[N+](=O)[O-],,C1CCOC1,,,,val
US20110124636A1,Nc1nc(C(=O)O)c(-c2cccc(F)c2)s1.O=C(NC[C@@H]1C[C@@H]2C[C@@H]2N1)C(F)(F)F>>Nc1nc(C(=O)N2[C@H](CNC(=O)C(F)(F)F)C[C@@H]3C[C@@H]32)c(-c2cccc(F)c2)s1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20010039344A1,O=C(O)c1ccc(CBr)cc1.[C-]#N>>N#CCc1ccc(C(=O)O)cc1,,CC#N,O,[Na+].[OH-],,val
US04066788,CCCCCCCCCCCCCCBr.O=Cc1ccc(O)cc1>>CCCCCCCCCCCCCCOc1ccc(C=O)cc1,,CN(C)C=O,,C[O-].[Na+],,val
US20150259367A1,BrCCCCBr.CCOC(=O)Cc1ccncc1[N+](=O)[O-]>>CCOC(=O)C1(c2ccncc2[N+](=O)[O-])CCCC1,,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],,val
US20030158163A1,COS(=O)(=O)OC.C[C@@H]1CC2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]34O[C@H]4C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)O>>COC(=O)[C@@]1(OC(=O)c2ccco2)[C@H](C)CC2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]34O[C@H]4C[C@@]21C,,CCOC(C)=O,,C1CCC2=NCCCN2CC1,,val
US20050054819A1,CCCC[C@H](NC(=O)OC1(c2nc3ccccc3s2)CCCC1)C(=O)C(C#N)=P(c1ccccc1)(c1ccccc1)c1ccccc1.Nc1cc[nH]n1.O=[O+][O-]>>CCCC[C@H](NC(=O)OC1(c2nc3ccccc3s2)CCCC1)C(=O)C(=O)Nc1cc[nH]n1,,C1CCOC1,ClCCl,N#N,,val
US05532255,N#Cc1ccc(N2CC(CN3CCC(C(=O)[O-])CC3)OC2=O)cc1>>N#Cc1ccc(N2CC(CN3CCC(C(=O)O)CC3)OC2=O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100016564A1,CCOC(=O)CN(CCNC(=O)OC(C)(C)C)CC(=O)OCC>>CC(C)(C)OC(=O)NCCN(CC(=O)O)CC(=O)O,,[Na+],[OH-],,,val
US20060111355A1,FC(F)(F)c1nc2c(OCCN3CCNCC3)cccc2[nH]1.[N-]=[N+]=Nc1cccc(F)c1[N+](=O)[O-]>>[N-]=[N+]=Nc1cccc(N2CCN(CCOc3cccc4[nH]c(C(F)(F)F)nc34)CC2)c1[N+](=O)[O-],,CCOC(C)=O,CS(C)=O,CCN(C(C)C)C(C)C,,val
US20100317643A1,O=C(Cl)c1c(Cl)cc(Cl)cc1Cl.[N-]=[N+]=Nc1cc(N)ccn1>>[N-]=[N+]=Nc1cc(NC(=O)c2c(Cl)cc(Cl)cc2Cl)ccn1,,CN(C)C=O,O,[H-].[Na+],,val
US05843904,CCOC(=O)CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1ccccc1)C(C)C>>CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N(CC(=O)O)Cc1ccccc1,,CO,,[Li+].[OH-],,val
US20040014753A1,COC(=O)C1CCCC(=O)N1C(=O)OC(C)(C)C>>COC(=O)C1CCCC(O)N1C(=O)OC(C)(C)C,,C1CCOC1,,[Cl-].[NH4+],,val
US20120129840A1,CCCC(C(=O)OC)c1c(C)nc(Cl)nc1-c1ccc(C)cc1.c1ccc(OC2CCCNC2)cc1>>CCCC(C(=O)OC)c1c(C)nc(N2CCCC(Oc3ccccc3)C2)nc1-c1ccc(C)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20150336905A1,CC1(c2ccc(Br)cc2)CO1.c1nc[nH]n1>>CC(O)(Cn1cncn1)c1ccc(Br)cc1,,CN1CCCC1=O,,[Na+].[OH-],[Cl-].[NH4+],val
US06166041,CS(=O)(=O)O.Clc1ccsc1.Nc1cc(Cl)cc(CCc2ccccn2)c1O>>Clc1cc(CCc2ccccn2)c2oc(-c3ccsc3)nc2c1,,C1COCCO1,Cc1ccccc1,O,,val
US20090054405A1,CC(=O)Nc1nc2cccc(Br)c2s1.COc1ccc(B(O)O)cc1>>COc1ccc(-c2cccc3nc(NC(C)=O)sc23)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20100204119A1,CC(C)(C(=O)O)c1ccc(N2CCOc3ncnc(N)c3C2=O)cc1.COc1ccc(CN)cc1>>COc1ccc(CNC(=O)C(C)(C)c2ccc(N3CCOc4ncnc(N)c4C3=O)cc2)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US05006531,CC(=O)N1CCC(=O)CC1.Nc1ccccc1-c1cc2ccccc2[nH]1>>CC(=O)N1CCC2(CC1)NC1=CC=CCC1=C1N=c3ccccc3=C12,,CC(=O)O,,CCO,,val
US05021420,ClCCCN1CC=C(c2ccccc2)CC1.O=S1(=O)Nc2ccc(Cl)c3cccc1c23>>O=S1(=O)c2cccc3c(Cl)ccc(c23)N1CCCN1CC=C(c2ccccc2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US05149357,COc1cc(OC)nc(Nc2cccc(Cl)c2C(=O)O)n1.O=[N+]([O-])c1ccc(O)cc1>>COc1cc(OC)nc(Nc2cccc(Cl)c2C(=O)Oc2ccc([N+](=O)[O-])cc2)n1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20030100770A1,C/C(=C\C=C(/C)C(=O)N1CCC[C@@H]1C(=O)OCc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)OCc1ccccc1>>CC(CCC(C)C(=O)N1CCC[C@@H]1C(=O)O)C(=O)N1CCC[C@@H]1C(=O)O,O=[Pt]=O,C1COCCO1,,[H][H],,val
US20100080786A1,CC(F)(F)C(=O)O.COc1ccc([C@@H](Oc2ccc3c(cnn3-c3cccc(Br)c3)c2)[C@@H](N)COC(C)(C)C)cn1>>COc1ccc([C@@H](Oc2ccc3c(cnn3-c3cccc(Br)c3)c2)[C@H](COC(C)(C)C)NC(=O)C(C)(F)F)cn1,,C1CCOC1,CCOC(C)=O,O,O=C(n1ccnc1)n1ccnc1,val
US20130324551A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.NC(=O)C1CCN(C2CC2)CC1>>NC(=S)C1CCN(C2CC2)CC1,,C1CCOC1,,,,val
US20120289522A1,CC(C)[Si](S)(C(C)C)C(C)C.CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CBr)cc3)cc2)CC1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CS[Si](C(C)C)(C(C)C)C(C)C)cc3)cc2)CC1,,CN(C)C=O,,,,val
US20080176947A1,COC(=O)[C@@H]1COC[C@H](OC)C1>>CO[C@H]1COC[C@@H](C(=O)O)C1,,CO,,[Li+].[OH-],,val
US20040176361A1,Cc1cccc2c(=O)[nH]c(C3CCN(N=O)CC3)cc12>>Cc1cccc2c(=O)[nH]c(C3CCN(N)CC3)cc12,[Zn],CC(=O)O,,,,val
US20090275537A1,CN(C(=O)NCc1cccc(F)c1Cl)[C@@H](CCC(=O)N1CCN(C(=O)OC(C)(C)C)CC1)COC(=O)Nc1cc2ccccc2cn1>>CN(C(=O)NCc1cccc(F)c1Cl)[C@@H](CCC(=O)N1CCNCC1)COC(=O)Nc1cc2ccccc2cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140323468A1,Brc1cncc(N2CCOCC2)c1.CC1(C)OB(c2cnc3c(c2)CCCN3C(N)=O)OC1(C)C>>NC(=O)N1CCCc2cc(-c3cncc(N4CCOCC4)c3)cnc21,,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20140128387A1,COCC1Cc2c(c(N)cc(C)c2-c2ccncc2)O1>>Cc1cc(N)c2c(c1)C[C@H](C)O2,O=[Pt]=O,CC(=O)O,,,,val
US04483781,CCOC(C)=O.O.O=C(O)c1ccccc1.O=C(OO)c1ccc(Cl)cc1.[Mg+2].[O-2]>>O.O.O.O.O=C(O[O-])c1ccc(Cl)cc1.O=C([O-])c1ccccc1.[Mg+2],,CCOC(C)=O,O,,,val
US20090247526A1,BrBr.CCOC(=O)Cc1ccnc(N)c1>>CCOC(=O)Cc1cc(N)ncc1Br,,CC(=O)O,,,,val
US20070185119A1,Cc1nc(N[C@H]2CCC[C@H](N)C2)nc2ccccc12.O=Cc1ccsc1>>Cc1nc(N[C@H]2CCC[C@H](NCc3ccsc3)C2)nc2ccccc12,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110230458A1,Cl.Cl.ClCCl.c1cc(-c2cc(OC3CCNCC3)nnc2C2CCCCC2)ccc1OC1CCCCC1>>CN1CCC(Oc2cc(-c3ccc(OC4CCCCC4)cc3)c(C3CCCCC3)nn2)CC1.Cl.Cl,,ClCCl,,CCOCC,Cl,val
US05910498,CC(C)(C)OC(=O)NCCC1CNC1.Nc1cc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)c(Cl)c32)c(F)cc1F.O=C(O)C(F)(F)F>>NCCC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(-c4cc(N)c(F)cc4F)c3c2Cl)C1.O=C(O)C(F)(F)F,,CCN(CC)CC,,C1COCCO1,Cl,val
US20040186292A1,CC(C)(C)OC(=O)N1CCC(=C(C(=O)NN)c2ccccc2)CC1.O=C(O)C1CN(C(=O)OCC2c3ccccc3-c3ccccc32)C1>>CC(C)(C)OC(=O)N1CCC(=C(C(=O)NNC(=O)C2CN(C(=O)OCC3c4ccccc4-c4ccccc43)C2)c2ccccc2)CC1,,ClCCl,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20040116328A1,CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2nc(Cl)n(C)c(=O)c21.CCOC(=O)CO>>CC#CCn1c(N2CCNCC2)nc2nc(OCC(=O)OCC)n(C)c(=O)c21,,CCO,,,,val
US20100292201A1,C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=NO)CC[C@@H]12.O=C(O)c1ccc(O)cc1>>C[C@]12CC[C@H](OC(=O)c3ccc(O)cc3)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=NO)CC[C@@H]12,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04024134,Cc1nnc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC=O)[C@H]3SC2)s1.[N-]=[N+]=C(c1ccccc1)c1ccccc1>>Cc1nnc(SCC2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)[C@@H](NC=O)[C@H]3SC2)s1,CC(=O)O,C1CCOC1,,,,val
US20140275172A1,CCOC(=O)CCc1ccc(O)c(C)c1C.OCc1cc(F)cc2cc(C(F)(F)F)oc12>>CCOC(=O)CCc1ccc(OCc2cc(F)cc3cc(C(F)(F)F)oc23)c(C)c1C,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040209887A1,CCOC(=O)/C=C(\C)OCC.COc1ccc(-c2c(C)ccn2N)c(C)c1>>COc1ccc(-c2c(C)cc3c(O)cc(C)nn23)c(C)c1,Cc1ccc(S(=O)(=O)O)cc1,ClC(Cl)Cl,,,,val
US20060287522A1,Cc1cccc(C)c1-c1ccc(C(=O)O)cc1.O=C(Cl)C(=O)Cl>>Cc1cccc(C)c1-c1ccc(C(=O)Cl)cc1,,ClCCl,,CN(C)C=O,,val
US20050191238A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCCCCc1ccc(CCOc2ncnc3ccccc23)cc1>>Cc1ccc(S(=O)(=O)OCCCCc2ccc(CCOc3ncnc4ccccc34)cc2)cc1,,CCOC(C)=O,c1ccncc1,,,val
US20050176775A1,CO.Cc1ccc(F)cc1C(=O)O>>COC(=O)c1cc(F)ccc1C,,CO,,C1COCCO1,Cl,val
US06632836B1,COc1ccccc1C(=O)NCC1(c2ccccc2)CC=CCC1.O=C(OO)c1cccc(Cl)c1>>COc1ccccc1C(=O)NCC1(c2ccccc2)CC[C@@H]2O[C@H]2C1,,ClCCl,,CCOCC,,val
US20160031855A1,CN(C)CCCl.Ic1cn[nH]c1>>CN(C)CCn1cc(I)cn1,,CC#N,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20130039906A1,CC(C)(C)OC(=O)N1CCC[C@@H](O)C1.Cn1cc(-c2cc3c(-c4cccc(Cl)n4)nn(C4CCCCO4)c3cn2)cn1>>Cn1cc(-c2cc3c(-c4cccc(O[C@@H]5CCCN(C(=O)OC(C)(C)C)C5)n4)nn(C4CCCCO4)c3cn2)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20090099169A1,CC(C)c1cc2cc(Br)cc(CBr)c2o1.CCOC(=O)c1cc(C)[nH]n1>>CCOC(=O)c1cc(C)n(Cc2cc(Br)cc3cc(C(C)C)oc23)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020193367A1,CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3cc(COC4CCCCO4)on3)c2)cc1C(F)(F)F>>CN(C)c1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3cc(CO)on3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040122063A1,BrCc1ncsc1CBr.CNNC>>CN1Cc2ncsc2CN1C,,CCO,,CCN(CC)CC,Cl,val
US20070213364A1,COC(=O)CCc1ccc(O)cc1.Cc1cc(-c2ccccc2)nn1Cc1ccc(CO)cc1>>COC(=O)CCc1ccc(OCc2ccc(Cn3nc(-c4ccccc4)cc3C)cc2)cc1,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090111864A1,CN(C)C(=O)CCCc1ccc(NC(C)(C)C#N)cc1F.CO.N#Cc1ccc(N=C=S)cc1C(F)(F)F.O>>CN(C)C(=O)CCCc1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C23CCC3)cc1F,,O,,CN(C)C=O,Cl,val
US05057513,Cl.O=C1C[C@]2(CCCC[C@H]2Cc2ccccc2)S(=O)(=O)CCN1Cc1cccnc1>>Cl.O=C1C[C@]2(CCCC[C@H]2Cc2ccccc2)S(=O)(=O)CCN1Cc1cccnc1,,CCOC(C)=O,ClCCl,,,val
US20070155919A1,CC(C)(Br)C(=O)Br.c1ccc2c(c1)CCC2>>CC1Cc2cc3c(cc2C1=O)CCC3,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20120122931A1,CC(=O)OCc1ccc2cc(-c3ccccc3)[nH]c2c1.CCOC(=O)c1cccc(C=O)n1>>CCOC(=O)c1cccc(Cc2c(-c3ccccc3)[nH]c3cc(COC(C)=O)ccc23)n1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20100056576A1,COC(=O)c1ccc(F)c(-c2c(F)cc(OC)cc2F)n1>>COc1cc(F)c(-c2nc(C(=O)O)ccc2F)c(F)c1,,C1CCOC1,CO,[Li+].[OH-],,val
US04309545,C=CC(C)=O.CCCCCC(C)Oc1ccc2c(c1)N(O)C(C)C(=CO)C2=O.CO.COc1cc(CNCCCNCCCCNCCCN)ccc1O>>CCCCCC(C)Oc1cc(O)c2c(c1)N(C=O)C(C)C(C=O)(CCC(C)=O)C2=O,,CCOCC,c1ccccc1,CCN(CC)CC,,val
US20160068531A1,CS(=O)(=O)Cl.O=C1N(Cc2cc3cc(Cl)ccc3n2CCN2CCNCC2)c2cnccc2C12CC2>>CS(=O)(=O)N1CCN(CCn2c(CN3C(=O)C4(CC4)c4ccncc43)cc3cc(Cl)ccc32)CC1,,ClCCl,,CCN(CC)CC,,val
US20090202480A1,C=CCCCCN(C)C(=O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C>>C=CCCCCN(C)C(=O)[C@@H]1C[C@@H](O)CN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04904669,Nc1cnc2ccccc2c1S.O=Cc1ccccc1>>c1ccc(-c2nc3cnc4ccccc4c3s2)cc1,,CCO,,Cl,,val
US20040127574A1,O=C1OC(c2ccc(F)cc2)C(Cc2ccc(C(F)(F)F)cc2)N1Cc1cccc2ccccc12>>OC(c1ccc(F)cc1)C(Cc1ccc(C(F)(F)F)cc1)NCc1cccc2ccccc12,,CCO,O,[Na+].[OH-],,val
US05739162,CCCC[Sn](CCCC)(CCCC)c1ccccc1NC(=O)CNC(=O)OCc1ccccc1.O=C(Cl)c1ccccc1F>>O=C(CNC(=O)OCc1ccccc1)Nc1ccccc1C(=O)c1ccccc1F,,ClC(Cl)Cl,,[F-].[K+],,val
US05071999,C=CCN.COC(OC)C(C)=O>>C=CCNC(C)C(OC)OC,,CCO,,[BH4-].[Na+],,val
US20130178420A1,CCCCCCCOc1ccc(C2(O)CCN(C(=O)OC(C)(C)C)CC2)cc1>>CCCCCCCOc1ccc(C2CCNCC2)cc1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US04073799,C=CC(CC(=O)CC(=O)OC)O[Si](C)(C)C.Cc1ccc(S(=O)(=O)N=[N+]=[N-])cc1>>C=CC(CC(=O)C(=[N+]=[N-])C(=O)OC)O[Si](C)(C)C,,CCN(CC)CC,,,,val
US20140296230A1,Nc1ccc(Br)cc1C(=O)c1ccccc1>>Nc1ccc(Br)cc1C(O)c1ccccc1,,CO,,O,[BH4-].[Na+],val
US20050272669A1,CN1CCNCC1.O=C(O)CCNS(=O)(=O)c1ccccc1[N+](=O)[O-]>>CN1CCN(C(=O)CCNS(=O)(=O)c2ccccc2[N+](=O)[O-])CC1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20090137624A1,C[C@H](N)c1ccc(F)cc1.O=[N+]([O-])c1cc(F)c(Br)cc1F>>C[C@H](Nc1cc(Br)c(F)cc1[N+](=O)[O-])c1ccc(F)cc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20130142754A1,COc1cnc(O[C@@H]2C[C@H]3C(=O)N[C@]4(C(=O)NS(=O)(=O)C5CC5)C[C@H]4C=CC(C)CCC[C@@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N3C2)c2cccc(Cl)c12.Cl>>COc1cnc(O[C@@H]2C[C@H]3C(=O)N[C@]4(C(=O)NS(=O)(=O)C5CC5)C[C@H]4C=CC(C)CCC[C@@H](C)[C@H](N)C(=O)N3C2)c2cccc(Cl)c12.Cl,,C1COCCO1,,,,val
US20130096118A1,Cc1c(B2OC(C)(C)C(C)(C)O2)cccc1-n1cnc2ccccc2c1=O.NC(=O)c1ccc(Br)c2c3c([nH]c12)CCN(C(c1ccccc1)(c1ccccc1)c1ccccc1)C3>>Cc1c(-c2ccc(C(N)=O)c3[nH]c4c(c23)CNCC4)cccc1-n1cnc2ccccc2c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US04224333,COc1ccc2c(c1)C(=C1CCN(Cc3ccccc3)CC1)C(=O)N2>>COc1ccc2c(c1)C(C1CCNCC1)C(=O)N2,,CC(=O)O,,,,val
US20080096877A1,CN(c1cccc2cc(C3=NCC(COS(C)(=O)=O)S3)[nH]c12)S(=O)(=O)c1ccccn1.c1nc[nH]n1>>CN(c1cccc2cc(C3=NCC(Cn4cncn4)S3)[nH]c12)S(=O)(=O)c1ccccn1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150259343A1,NC(=O)CN1CCC(C2CC2)c2ccccc21>>NCCN1CCC(C2CC2)c2ccccc21,,C1CCOC1,,B,CO,val
US20160122342A1,CC(C)=O.CCN(c1cccc2c1CC=CCCc1cc(C)[nH]c(=O)c1CNC2=O)C1CCNCC1>>CCN(c1cccc2c1CC=CCCc1cc(C)[nH]c(=O)c1CNC2=O)C1CCN(C(C)C)CC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20110118354A1,C=C(C)C.COC(=O)C1=CCC(CO)CC1(C)c1ccc(Cl)c(C(F)(F)F)c1>>COC(=O)C1=CCC(COC(C)(C)C)CC1(C)c1ccc(Cl)c(C(F)(F)F)c1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20040033896A1,BrBr.Cc1cnc(-c2ccc(C(F)(F)F)cc2)nc1C>>Cc1cnc(-c2ccc(C(F)(F)F)cc2)nc1CBr,,CC(=O)O,,,,val
US20120178623A1,COC1CCC(/C=C2\CC(=O)C(c3c(C)cc(C)cc3C)C2=O)CC1>>COC1CCC(CC2CC(=O)C(c3c(C)cc(C)cc3C)C2=O)CC1,[Pd],CCO,,,,val
US20160137617A1,C=CCNC(=O)CCCCCCCNC(=O)OCc1ccccc1>>C=CCNCCCCCCCCNC(=O)OCc1ccccc1,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US05747517,O=C1CSC(=S)N1.O=Cc1ccc(OCc2c(F)cccc2Cl)cc1>>O=C1NC(=S)SC1=Cc1ccc(OCc2c(F)cccc2Cl)cc1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20110224225A1,COc1cc(F)ccc1B(O)O.Clc1cc(Br)ccn1>>COc1cc(F)ccc1-c1ccnc(Cl)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20020019404A1,Cc1nc(C)c(/C=C/C(=O)N(C)C)s1.N=C(N)Nc1ccc(Cc2ccncc2)cc1>>Cc1nc(C)c(-c2ccnc(Nc3ccc(Cc4ccncc4)cc3)n2)s1,,COCCO,,Cl,[Na+].[OH-],val
US04873236,CCN(CC)CC1COCCN1CCN.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>CCN(CC)CC1COCCN1CCNC(=O)N1c2ccccc2C(=O)Nc2cccnc21,,CC#N,,,,val
US20140243288A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=C1O[C@@H](CO)CN1c1ccc(Br)c(F)c1>>CC1(C)OB(c2ccc(N3C[C@H](CO)OC3=O)cc2F)OC1(C)C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O,CC(=O)[O-].[K+],val
US20090137642A1,CCOC(=O)c1sc(N)nc1-c1ccccc1.NN>>NNC(=O)c1sc(N)nc1-c1ccccc1,,CO,,O,O,val
US20130316943A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@@H](COc1ccc(C(F)(F)F)cc1)NC(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N[C@H](COc1ccc(C(F)(F)F)cc1)C(=O)O,,CCOC(C)=O,,Cl,,val
US20030176698A1,CCCN1C(=O)N2C[C@@H](Cc3ccccc3)N=C2c2c1nc(Br)n2COC.CS>>CCCN1C(=O)N2C[C@@H](Cc3ccccc3)N=C2c2c1nc(SC)n2COC,,CN(C)C=O,,O,[Na],val
US05110956,C=CCc1ccc2c(c1)OCO2.CC(O)=S>>SCCCc1ccc2c(c1)OCO2,,CCO,O,O=S(=O)(O)O,[Na+].[OH-],val
US05852014,BrCCCOc1ccccc1.O=C(NCC1CCNCC1)c1c2n(c3ccccc13)CCCO2>>O=C(NCC1CCN(CCCOc2ccccc2)CC1)c1c2n(c3ccccc13)CCCO2,,CC#N,CN(C)C=O,CCN(CC)CC,,val
US20060275913A1,CCOc1cc(C#N)ccc1CON1C(=O)c2ccccc2C1=O>>CCOc1cc(C#N)ccc1CON,,CCO,,NN,O,val
US20100311778A1,CC1(C)CC(N)c2ccccc2O1.CCN(CC)CC.Cl.O=C(O)CCc1c[nH]c2ccccc12>>O=C(CCc1c[nH]c2ccccc12)NC1CC2(CCC2)Oc2ccc(Cl)cc21,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20030073849A1,CNC.Cc1ccc(S(=O)(=O)n2cc([C@@H]3C[C@H]3C=O)c3cc(F)c(F)cc32)cc1>>CN(C)CC1CC1c1c[nH]c2cc(F)c(F)cc12,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US06610694B1,CCOC(=O)C(=O)OCC.NNc1ccc(Cl)nn1>>CCOC(=O)c1nnc2ccc(Cl)nn12,,CCO,,,,val
US20110190280A1,CCNc1nc(-c2ccc(Cl)c(C)c2)c(-c2ccnc(Cl)n2)s1.Nc1ccc(OCCN2CCCC2)c(Cl)c1>>CCNc1nc(-c2ccc(Cl)c(C)c2)c(-c2ccnc(Nc3ccc(OCCN4CCCC4)c(Cl)c3)n2)s1,,OCC(F)(F)F,,Cl,,val
US20120184587A1,COc1c(C(=O)N(C)C)cc(C(=O)O)cc1C(F)(F)F.O=S(Cl)Cl>>COc1c(C(=O)N(C)C)cc(C(=O)Cl)cc1C(F)(F)F,,CN(C)C=O,,Cc1ccccc1,,val
US04725597,C1CNCCN1.ClCCCCc1ccc(Cl)cc1>>Clc1ccc(CCCCN2CCNCC2)cc1,,CCO,,,,val
US20100298288A1,COC(=O)c1cc(C#N)ccc1O.O=[N+]([O-])O>>COC(=O)c1cc(C#N)cc([N+](=O)[O-])c1O,,CCOC(C)=O,,,,val
US04788199,O=S(Cl)Cl.OCc1cc(-c2ccccc2)cc2ccccc12>>ClCc1cc(-c2ccccc2)cc2ccccc12,,ClC(Cl)Cl,,,,val
US20030134840A1,COc1cccc(C(=O)NCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1.Cl>>Cl.O=C(NCCN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cccc(O)c1,,ClCCl,,BrB(Br)Br,,val
US20080027053A1,CC(=O)N(C[C@H]1CN(c2ccc(N3Cc4cn(C)nc4C3)c(F)c2)C(=O)O1)C(=O)OC(C)Cl.CC(C)(C)OP(=O)([O-])OC(C)(C)C>>CC(=O)N(C[C@H]1CN(c2ccc(N3Cc4cn(C)nc4C3)c(F)c2)C(=O)O1)C(=O)OC(C)OP(=O)(OC(C)(C)C)OC(C)(C)C,,C1CCOC1,,[I-].[Na+],,val
US20070293516A1,Cn1cc(I)c2c(N)ncnc21.OB(O)c1cc2ccccc2s1>>Cn1cc(-c2cc3ccccc3s2)c2c(N)ncnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20040157804A1,CO.COc1c2c(c(O)c3ncccc13)C(=O)N(Cc1ccc(F)cc1)C2O>>COc1c2c(c(O)c3ncccc13)C(=O)N(Cc1ccc(F)cc1)C2OC,,CO,,ClCCl,O=C(O)C(F)(F)F,val
US05207947,CCCCCCCCC(OC(=O)c1ccc(OCc2ccccc2)cc1)C(F)(F)F>>CCCCCCCCC(OC(=O)c1ccc(O)cc1)C(F)(F)F,[Pd],CCO,,,,val
US05733849,C#CCBr.CC(C)(C)n1nc(-c2cc(Cl)nc(Cl)c2)[nH]c1=O>>C#CCn1c(-c2cc(Cl)nc(Cl)c2)nn(C(C)(C)C)c1=O,O,CCOC(C)=O,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US20130245021A1,BrBr.Fc1ccc2nccn2n1>>Fc1ccc2ncc(Br)n2n1,,CC(=O)O,,O,,val
US20150232460A1,CC1(N)CCCC1NC(=O)c1ccccc1-n1nccn1.FC(F)(F)c1cnc(Cl)cn1>>CC1(Nc2cnc(C(F)(F)F)cn2)CCCC1NC(=O)c1ccccc1-n1nccn1,,CS(C)=O,,CCN(C(C)C)C(C)C,Cl,val
US20040058912A1,COC(=O)C(c1ccccc1)N1CCCc2cc(OC)c(OC)cc2C1Cc1ccc(OC)c(OC)c1>>COc1ccc(CC2c3cc(OC)c(OC)cc3CCCN2C(C(=O)O)c2ccccc2)cc1OC,,C1COCCO1,CO,[Na+].[OH-],,val
US20130217666A1,COC(=O)C(C)(O)C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2.N#CC1CNC1>>CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)C(=O)N1CC(C#N)C1,,CO,,CCN(CC)CC,Cl,val
US20040204386A1,BrBr.Nc1nc(Cl)cc(Cl)n1>>Nc1nc(Cl)c(Br)c(Cl)n1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US05710319,NCc1ccc(Br)cc1F.O=C(Cl)Cl>>O=C=NCc1ccc(Br)cc1F,,Clc1ccccc1,,,,val
US04089855,COc1ccc2c(c1)[C@]13CCN(C(=O)C4CCC4)[C@H](C2)[C@]1(O)CCC(=O)C3>>COc1ccc2c(c1)[C@]13CCN(CC4CCC4)[C@H](C2)[C@]1(O)CC[C@H](O)C3,,C1CCOC1,,B,Cl,val
US04399282,CCCO.CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1>>CCc1c2c(nc3ccccc13)-c1cc3c(c(=O)n1C2)COC(=O)[C@]3(O)CC,,O=S(=O)(O)O,,OO,,val
US04910201,O=c1c(Cl)c(Cl)cnn1-c1ccc(Cl)cn1.OCc1ccc(Cl)cc1>>O=c1c(Cl)c(OCc2ccc(Cl)cc2)cnn1-c1ccc(Cl)cn1,,CN(C)C=O,,[K+].[OH-],,val
US20090111983A1,NC1(C(=O)OCc2ccccc2)CCCCC1.O=C(Cl)N1CCNC1=O>>O=C1NCCN1C(=O)NC1(C(=O)OCc2ccccc2)CCCCC1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20100062050A1,CC(C)(C)OC(=O)N[C@@H](CCC(=O)O)C(=O)OCc1ccccc1.Cc1ccc(S(=O)(=O)NC(=N)NCCCCCCO)cc1>>Cc1ccc(S(=O)(=O)NC(=N)NCCCCCCOC(=O)CCC(NC(=O)OC(C)(C)C)C(=O)OCc2ccccc2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20050090559A1,COc1ccc(F)cc1C(C)(C)CC(O)(C=Nc1ccc(F)c2nc(C)ncc12)C(F)(F)F>>Cc1ncc2c(N)ccc(F)c2n1,[Pd],CCN(CC)CC,CCOC(C)=O,,,val
US20090137581A1,C[C@@H](c1cc2cccc(Cl)c2nc1Cl)N1C(=O)c2ccccc2C1=O.FC(F)(F)c1cc[nH]n1>>C[C@@H](c1cc2cccc(Cl)c2nc1-n1ccc(C(F)(F)F)n1)N1C(=O)c2ccccc2C1=O,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20030199440A1,CC(C)(C)OC(=O)CN(CC1CCCC1)S(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1.Cl>>Cl.N=C(N)Nc1ncc(Cl)c2ccc(S(=O)(=O)N(CC(=O)O)CC3CCCC3)cc12,,C1COCCO1,,,,val
US05990105,CN.O=S(=O)(c1ccccc1)c1cc(Br)nc(Br)c1>>CNc1cc(S(=O)(=O)c2ccccc2)cc(Br)n1,,C1COCCO1,CCO,,,val
US07943610B2,CCCn1nc2c(Cl)nc3ccccc3c2c1N(CCC1CCN(C(=O)OC(C)(C)C)CC1)C(=O)OC(C)(C)C.Cl.N>>CCCn1nc2c(N)nc3ccccc3c2c1NCCC1CCNCC1.Cl.Cl,,CCO,CO,,,val
US05246937,CC(=O)OCC(CCn1cnc2c(Cl)nc(N)nc21)COC(C)=O>>CC(=O)OCC(CCn1cnc2cnc(N)nc21)COC(C)=O,[Pd],CO,,O=C[O-].[NH4+],,val
US20060276433A1,CN(C)Cc1ccc(C=O)cc1I.NNc1ccc(-c2cnco2)cc1>>CN(C)Cc1ccc(C=NNc2ccc(-c3cnco3)cc2)cc1I,,CCO,,,,val
US20070287711A1,COC(=O)c1cc(I)cc(C(=O)N(C)C)c1.COc1ccccc1-c1nn(COCC[Si](C)(C)C)c2ncc(B3OC(C)(C)C(C)(C)O3)cc12>>COC(=O)c1cc(C(=O)N(C)C)cc(-c2cnc3c(c2)c(-c2ccccc2OC)nn3COCC[Si](C)(C)C)c1,,C1CCOC1,CC#N,O,,val
US20140135316A1,CC1(C)OB(c2ccc(N)nc2)OC1(C)C.Cc1nnc2n1-c1ccccc1NCC2Br>>Cc1nnc2n1-c1ccc(-c3ccc(N)nc3)cc1NCC2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060004017A1,COc1ccc2cc(C#N)cnc2c1>>N#Cc1cnc2cc(O)ccc2c1,,c1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05854272,O=C1c2ccccc2C(=O)N1CCN1C[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1COCc1ccccc1>>NCCN1C[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1COCc1ccccc1,,CCO,,NN,O,val
US20030060460A1,COC(=O)c1ccc(Cl)cc1O>>OCc1ccc(Cl)cc1O,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20050107339A1,CCOc1cc(C(O)c2ccc(OC)c(C)c2)ccc1OC>>CCOc1cc(C(=O)c2ccc(OC)c(C)c2)ccc1OC,O=[Mn]=O,ClCCl,,,,val
US05306728,O=C(CBr)CCCBr.Oc1cccc(-c2ccsc2)c1>>O=C(CCCBr)COc1cccc(-c2ccsc2)c1,,CN(C)C=O,O,CCOCC,[H-].[Na+],val
US20160060273A1,CCOc1nc(CO[Si](C(C)C)(C(C)C)C(C)C)ccc1OCc1ccccc1>>CCOc1nc(CO[Si](C(C)C)(C(C)C)C(C)C)ccc1O,[Pd],CCOC(C)=O,,[H][H],,val
US20080221100A1,NC1CCN(C(=O)CCCN2CCOCC2)CC1.O=C=Nc1ccc(F)c(F)c1>>O=C(Nc1ccc(F)c(F)c1)NC1CCN(C(=O)CCCN2CCOCC2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20050267093A1,COc1cc([N+](=O)[O-])ccc1OCCN1CC(C)CC(C)C1>>COc1cc(N)ccc1OCCN1CC(C)CC(C)C1,,CO,ClCCl,,,val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.Oc1ccc(Cl)nc1>>COc1cc2nccc(Oc3ccc(Cl)nc3)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,O,,val
US20070197551A1,Nn1c(SCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2cc(C(=O)O)ccc2c1=O.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Nc1ccc2c(=O)n(N)c(SCCCN3CCN(c4ccc5ccccc5n4)CC3)nc2c1,,CC(C)(C)O,,CCN(CC)CC,,val
US05021412,Fc1cc(CN=C=S)ccc1OCC(F)(F)F.NCC(F)(F)F>>Fc1cc(CNC(=S)NCC(F)(F)F)ccc1OCC(F)(F)F,,CCOC(C)=O,,,,val
US06800627B1,COC(=O)c1cc2ccc(Cl)cc2[nH]1.N#CCCl>>Cl.Clc1ccc2c(c1)N1CCNCC1C2,,CN(C)C=O,,[H-].[Na+],,val
US20100069359A1,CC(C)(C)OC(=O)Nc1cc2c(cn1)CC1(C2)C(=O)Nc2ncccc21.O=C(O)C(F)(F)F>>Nc1cc2c(cn1)CC1(C2)C(=O)Nc2ncccc21.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20040127574A1,NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)cc1.O=C(Br)CBr>>O=C(CBr)NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)cc1,,CCOC(C)=O,O,O=C([O-])O.[Na+],,val
US20110301175A1,OCCBr.Oc1cccc(Nc2ncc(-c3ccc(OC(F)F)cc3)cn2)c1>>OCCOc1cccc(Nc2ncc(-c3ccc(OC(F)F)cc3)cn2)c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110251165A1,CCOC(=O)/C=C/C(F)(F)c1ccccc1>>CCOC(=O)CCC(F)(F)c1ccccc1,[Pd],CO,,,,val
US20100216860A1,N#Cc1cccc(CBr)c1.Nc1n[nH]c2cccc(F)c12>>N#Cc1cccc(Cn2nc(N)c3c(F)cccc32)c1,,CS(C)=O,,O,[K+].[OH-],val
US05639766,CCOC(=O)[C@@H]1CCCN(CCBr)C1.ON=C1c2ccccc2CCC1c1ccccc1>>CCOC(=O)[C@@H]1CCCN(CCON=C2c3ccccc3CCC2c2ccccc2)C1,,CC(C)=O,,Br,O=C([O-])[O-].[K+].[K+],val
US20120202785A1,Nc1ccccc1.O=[N+]([O-])c1ccc(F)cc1F>>O=[N+]([O-])c1ccc(F)cc1Nc1ccccc1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20060241127A1,O=[N+]([O-])c1ccc(F)c(F)c1.Oc1ccc2[nH]ncc2c1>>O=[N+]([O-])c1ccc(Oc2ccc3[nH]ncc3c2)c(F)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150291593A1,COC(=O)[C@@H]1C(C)CN1C(=O)c1ccccn1>>CC1CN(C(=O)c2ccccn2)[C@@H]1C(=O)O,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20060004046A1,N#Cc1cnc2ccc(C=O)cc2c1OC1CCOCC1.O=C1CSC(NC2CC2)=N1>>N#Cc1cnc2ccc(/C=C3\SC(NC4CC4)=NC3=O)cc2c1OC1CCOCC1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US05143831,CC(C)(O/N=C(/C(=O)NCC=O)c1csc(N)n1)C(=O)O.COC(CC(C)(C)O)OC.CS(=O)(=O)O.O>>CC(C)(O)C[C@@H](O)[C@H](O)C(=O)CO,,O,,,,val
US20040220403A1,CC(C)(C)OC(=O)N1C[C@@H]2CNCCN2[C@H](C(c2ccccc2)c2ccccc2)C1.O=C(O)c1cccnc1>>CC(C)(C)OC(=O)N1C[C@@H]2CN(C(=O)c3cccnc3)CCN2[C@H](C(c2ccccc2)c2ccccc2)C1,,ClCCl,,CCN(CC)CC,C[n+]1ccccc1Cl.[I-],val
US20150307451A1,COC(=O)c1cc(Cc2ccc(Cl)cc2)c(C)c(C)c1C=O.N[C@H]1COCC[C@@H]1O>>Cc1c(Cc2ccc(Cl)cc2)cc2c(c1C)CN([C@H]1COCC[C@@H]1O)C2=O,,C1CCOC1,,,,val
US20100210635A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCN(C(=O)CCc2ccccc2Oc2ccccc2C#N)[C@H](Cc2ccccc2)C1>>CC(=O)NCc1ccccc1Oc1ccccc1CCC(=O)N1CCN(C(=O)OC(C)(C)C)C[C@H]1Cc1ccccc1,[Ni],,,,,val
US20140121198A1,N#CC=CC1CCCC(Nc2c([N+](=O)[O-])cnc3ccsc23)C1>>N#CCCC1CCCC(Nc2c(N)cnc3ccsc23)C1,[Pd],CO,,,,val
US20030199528A1,BrCCc1ccccc1.Cn1c(=O)[nH]c(=O)c2c1nc(Br)n2Cc1ccccc1Br>>Cn1c(=O)n(CCc2ccccc2)c(=O)c2c1nc(Br)n2Cc1ccccc1Br,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04070481,CCCCCCCCCCCC(=O)O.Oc1cccc2c(Cl)cccc12>>CCCCCCCCCCCC(=O)c1ccc2c(Cl)cccc2c1O,,O,,,,val
US20040063735A1,C[Si](C)(C)CCS(=O)(=O)n1ccc2cc(CC(NC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N3CCC(N4CCCCC4)CC3)ccc21>>O=C(NC(Cc1ccc2[nH]ccc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1,,CC#N,,[Cs+].[F-],,val
US20040087796A1,BrCc1ccccc1.COC(=O)c1cccc2[nH]c3c(c12)C(=O)CCC3>>COC(=O)c1cccc2c1c1c(n2Cc2ccccc2)CCCC1=O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US06225306B1,CC(C)(C)[Si](C)(C)Cl.O=C1Nc2ccccc2C(=O)N2C[C@H](O)C[C@@H]12>>CC(C)(C)[Si](C)(C)O[C@@H]1C[C@H]2C(=O)Nc3ccccc3C(=O)N2C1,,CN(C)C=O,,c1c[nH]cn1,,val
US20100029684A1,CC(C)(C)OC(=O)CCl.COc1ncc([N+](=O)[O-])cc1C>>COc1nc(CC(=O)OC(C)(C)C)c([N+](=O)[O-])cc1C,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20100076026A1,COC(=O)c1ccc(C)c(N=C=O)c1.Clc1ccc(-n2nc3ccccc3c2NC2CCCCC2)cc1>>COC(=O)c1ccc(C)c(NC(=O)N(c2c3ccccc3nn2-c2ccc(Cl)cc2)C2CCCCC2)c1,,ClCCCl,,CCN(CC)CC,,val
US20090176798A1,CN1CCC(COC(=O)Oc2ccc([N+](=O)[O-])cc2)CC1.c1ccc2c(c1)CCNC2>>CN1CCC(COC(=O)N2CCc3ccccc3C2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20150232464A1,CCOC(=O)C(N=C(c1ccccc1)c1ccccc1)c1cnn(C)c1>>CCOC(=O)C(N)c1cnn(C)c1,,C1COCCO1,,Cl,,val
US20160251340A1,CC1(C)COc2cccc(Oc3ccc(N)cc3)c21.C[C@@H](NC(=O)OC(C)(C)C)C(=O)O>>C[C@@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(Oc2cccc3c2C(C)(C)CO3)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090270350A1,COC(=O)c1ccc(C)c(-n2c(C)cc(O)c(Cl)c2=O)c1.N#Cc1cc(F)ccc1CBr>>COC(=O)c1ccc(C)c(-n2c(C)cc(OCc3ccc(F)cc3C#N)c(Cl)c2=O)c1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20150056141A1,CCOC(=O)c1c(NC(C)=O)sc2c(OCCN(CC)CC)c(Br)ccc12.Cc1cccc(B(O)O)c1>>CCOC(=O)c1c(NC(C)=O)sc2c(OCCN(CC)CC)c(-c3cccc(C)c3)ccc12,,CC#N,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US05859051,CCCc1c(OCCCSc2ccc(CC(=O)OC)cc2Cl)ccc2cc(CC)c(=O)oc12>>CCCc1c(OCCCSc2ccc(CC(=O)O)cc2Cl)ccc2cc(CC)c(=O)oc12,,CO,O,Cl,[K+].[OH-],val
US04145546,Clc1nsnc1CBr.NCCS>>NCCSCc1nsnc1Cl,,CCO,,C,C[O-].[Na+],val
US20100216986A1,C=Cc1ccc(-c2ccc(-c3ccc(CC)cc3)cc2F)[se]1>>CCc1ccc(-c2ccc(-c3ccc(CC)[se]3)c(F)c2)cc1,[Pd],CCOC(C)=O,,,,val
US20140045936A1,C=C/C=C/c1ccccc1.COC(=O)C(=[N+]=[N-])c1ccc(Br)cc1>>COC(=O)C1(c2ccc(Br)cc2)CC1/C=C/c1ccccc1,,Cc1ccccc1,,,,val
US20070142434A1,COC(=O)C1CCN(CCCOc2ccc(-n3nc4ccccc4c3Cl)cc2)CC1>>OCC1CCN(CCCOc2ccc(-n3nc4ccccc4c3Cl)cc2)CC1,,C1CCOC1,,[BH4-].[Na+],,val
US20070197516A1,CC#C[C@H](O)[C@H](CNC(=O)OCc1ccccc1)N1CC[C@H](NC(=O)c2cccc(C(F)(F)F)c2)C1=O>>CCC[C@H](O)[C@H](CN)N1CC[C@H](NC(=O)c2cccc(C(F)(F)F)c2)C1=O,[Pd],CO,,,,val
US20020055465A1,CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(N)=O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2>>CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(N)=O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2,,C1CCOC1,CC#N,O=C(O)C(F)(F)F,,val
US05459243,CC(O)[Si](C)(C)C.Clc1ccnc(Cl)n1>>C[Si](C)(C)CCOc1nccc(Cl)n1,,CCOCC,,C1CCOC1,[Li]CCCC,val
US04331670,Cc1nc(N)c(Cl)c(C)c1Cl.O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(C(F)(F)F)c1>>Cc1nc(Nc2c([N+](=O)[O-])cc([N+](=O)[O-])cc2C(F)(F)F)c(Cl)c(C)c1Cl,,CN(C)C=O,,[K+].[OH-],,val
US05206418,CCOC(=O)Cc1ccc2c(c1)CCC(NS(=O)(=O)c1ccc(Cl)cc1)C2>>O=C(O)Cc1ccc2c(c1)CCC(NS(=O)(=O)c1ccc(Cl)cc1)C2,,CCO,,[Na+].[OH-],,val
US20060252790A1,CCn1ncc2c(NC3CCCC3)c(C(=O)NNC(=O)C(C)C)cnc21.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCn1ncc2c(NC3CCCC3)c(-c3nnc(C(C)C)s3)cnc21,,CC#N,,,,val
US06562823B1,Cc1cc(Cl)c(O)c(Cl)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(Cl)c(OS(=O)(=O)C(F)(F)F)c(Cl)c1,,ClCCl,,c1ccncc1,,val
US20060160851A1,BrBr.COC(=O)Cc1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1>>COC(=O)Cc1ccc(OC2CCNCC2)c(Br)c1,,CC(=O)O,,,,val
US20150376160A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4sc(Cl)cc4NC(=O)O[C@H](C)c4ccccc4Cl)cc3)cc2)CC1>>C[C@@H](OC(=O)Nc1cc(Cl)sc1-c1ccc(-c2ccc(C3(C(=O)O)CC3)cc2)cc1)c1ccccc1Cl,,CC(C)O,,Cl,[Na+].[OH-],val
US20150105366A1,CS(=O)O.Cc1cc(C(O)(c2ccc(Cl)cc2)c2cncn2C)cc2c(Cl)c(Cc3ccc(-n4cccn4)cc3)c(Cl)nc12>>Cc1cc(C(O)(c2ccc(Cl)cc2)c2cncn2C)cc2c(Cl)c(Cc3ccc(-n4cccn4)cc3)c(S(C)(=O)=O)nc12,,CN(C)C=O,,,,val
US20040236109A1,CC(=O)N1c2ccc(N)cc2C(C)(c2ccccc2)CC1(C)C.CC(=O)Oc1ccccc1C(=O)O>>CC(=O)Oc1ccccc1C(=O)Nc1ccc2c(c1)C(C)(c1ccccc1)CC(C)(C)N2C(C)=O,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070203159A1,COc1ccc(Cn2cnc3c(-c4ccco4)nc(SC)nc32)cc1.O=C(OO)c1cccc(Cl)c1>>COc1ccc(Cn2cnc3c(-c4ccco4)nc(S(C)=O)nc32)cc1,,ClCCl,,,,val
US20140121200A1,CC1(C)OB(c2ccc(N3CCNCC3)cc2)OC1(C)C.OCCBr>>CC1(C)OB(c2ccc(N3CCN(CCO)CC3)cc2)OC1(C)C,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US05010108,CN(CCN)C1CC1.COc1cc(N)c(Cl)cc1C(=O)O>>CN(CCc1ccccc1C(N)=O)C1CC1,,C1CCOC1,,O,O=C(n1ccnc1)n1ccnc1,val
US04902698,Cc1cc(N)cnc1CCCC#N.O=S(=O)(Cl)c1ccccc1>>Cc1cc(NS(=O)(=O)c2ccccc2)cnc1CCCC#N,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20100028262A1,COc1ccc(C(C)=O)c(OC)c1OC.O=Cc1ccc2c(c1)OCO2>>COc1ccc(C(=O)/C=C/c2ccc3c(c2)OCO3)c(OC)c1OC,,CO,,[Na+].[OH-],,val
US20050164960A1,C[C@@]1(OC(=O)c2ccccc2)[C@H](OC(=O)c2ccccc2)[C@@H](COC(=O)c2ccccc2)O[C@H]1n1cnc2c(Cl)nc(N)nc21>>C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(Cl)nc(N)nc21,,C1CCOC1,,[Li+].[OH-],,val
US20110151258A1,COc1ccccc1OCC(O)CN1CCNCC1.Cc1cccc(C)c1NC(=O)CN1CCNCC1>>COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1,,CC(C)=O,,,,val
US05108485,CCn1c(C)nc2c(C(=O)NC(C)(C(N)=O)C(C)C)c(C(=O)O)ccc21>>CCn1c(C)nc2c(C3=NC(C)(C(C)C)C(=O)N3)c(C(=O)O)ccc21,,O,,Cl,[Na+].[OH-],val
US20040082630A1,O=S(Cl)Cl.OCc1ccc(-n2nccn2)cc1>>ClCc1ccc(-n2nccn2)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20110301143A1,CC(C)(C)OC(=O)N1CCN(c2cc(C(F)(F)F)ccc2Cl)CC1.Cl>>Cl.FC(F)(F)c1ccc(Cl)c(N2CCNCC2)c1,,CCOCC,,C1COCCO1,,val
US20130079338A1,C=[N+]=[N-].C[Si](C)(C)CCOCn1c(=O)ccc2cc(/C=C/c3cnc(Nc4ccc(OC(F)F)cc4)nc3)ccc21>>C[Si](C)(C)CCOCn1c(=O)ccc2cc(C3CC3c3cnc(Nc4ccc(OC(F)F)cc4)nc3)ccc21,,CCOCC,CCOCC,,,val
US20140107094A1,COc1nc2ccc(C(=O)C3CN(C(=O)OC(C)(C)C)C3)cc2c(Cl)c1Cc1ccc(C(F)(F)F)cc1.Cn1ccnn1>>COc1nc2ccc(C(O)(c3cnnn3C)C3CN(C(=O)OC(C)(C)C)C3)cc2c(Cl)c1Cc1ccc(C(F)(F)F)cc1,,C1CCOC1,,[Li]CCCC,,val
US20060116364A1,CCOCCNC(=O)OC(C)(C)C.CI>>CCOCCN(C)C(=O)OC(C)(C)C,,C1CCOC1,,O,[H-].[Na+],val
US20070155721A1,CCOC(=O)c1cc2c(Oc3cc(F)c(F)cc3N)cccc2[nH]1>>CCOC(=O)c1cc2c(Oc3ccc(F)c(F)c3)cccc2[nH]1,,CCOCC,CN(C)C=O,CC(C)(C)ON=O,,val
US05207947,CCCCCCC(OC(=O)c1ccc(O)cc1)C(F)(F)F.CCCCCCCCOc1ccc(-c2ccc(C(=O)Cl)cc2)cc1>>CCCCCCCCOc1ccc(-c2ccc(C(=O)Oc3ccc(C(=O)OC(CCCCCC)C(F)(F)F)cc3)cc2)cc1,,ClCCl,O,CCN(CC)CC,,val
US20030060626A1,C[S-].Clc1cc(-c2ccccc2)ncn1>>CSc1cc(-c2ccccc2)ncn1,,CN(C)C=O,,O,,val
US20150018422A1,COc1ccc(F)c(-c2ccc(O)cc2CC(C)(C)C)c1.OCCCc1cccc(CO)c1>>COc1ccc(F)c(-c2ccc(OCc3cccc(CCCO)c3)cc2CC(C)(C)C)c1,,C1CCOC1,Cc1ccccc1,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120232081A1,Cc1c(F)cccc1Cc1c(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c2ccccn2c1-c1ccccc1>>Cc1c(F)cccc1Cc1c(C(=O)N2CCNCC2)c2ccccn2c1-c1ccccc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20120184512A1,CC(C)(O)c1ncc(-c2cc(N)c(N)c(C3CCCO3)c2F)cn1.CCNC(=O)N=C(NC(=O)NCC)SC>>CCNC(=O)Nc1nc2cc(-c3cnc(C(C)(C)O)nc3)c(F)c(C3CCCO3)c2[nH]1,,O=S(=O)(O)O,,C1COCCO1,O=C([O-])O.[Na+],val
US03953429,Br.CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H]5O[C@@H]5C[C@]4(C)[C@H]3CC[C@]12C>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](Br)C[C@]4(C)[C@H]3CC[C@]12C,,ClC(Cl)Cl,,,,val
US20110021496A1,BrCc1ccccc1.CC(C)(C)OC(=O)N1CCc2cnccc21>>CC(C)(C)OC(=O)N1CCC2CN(Cc3ccccc3)CCC21,,CC#N,,[BH4-].[Na+],,val
US04096147,C1=NCCc2ccccc21.CC(=O)C1=CCCC1.COc1cc2c(cc1OC)CCN=C2>>COc1cc2c(cc1OC)C1CC(=O)C3CCCCC3N1CC2,,CC(C)=O,,Cl,Cl,val
US20070232652A1,CC(C)(C)OC(=O)N1CC[C@@H](c2ccc(F)cc2)[C@H](C(=O)O)C1>>CC(C)(C)OC(=O)N1CC[C@@H](c2ccc(F)cc2)[C@H](CO)C1,,C1CCOC1,,,,val
US04129654,CCI.Cn1c(=O)[nH]c(=O)c2conc21>>CCn1c(=O)c2conc2n(C)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100174065A1,CC(C)(C)OC(=O)N1CCc2ccc(C(=N)NO)cc2CC1.O=C(O)c1ccc(-c2ccccc2)c(C(F)(F)F)c1>>CC(C)(C)OC(=O)N1CCc2ccc(-c3noc(-c4ccc(-c5ccccc5)c(C(F)(F)F)c4)n3)cc2CC1,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US04526608,CNO.O=[N+]([O-])c1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1[N+](=O)[O-]>>CN(O)c1cc(Oc2ncc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20120053218A1,NNC(=O)c1ccccc1OC(F)(F)F.O=C=NC1CC1>>O=C(NNC(=O)c1ccccc1OC(F)(F)F)NC1CC1,,C1CCOC1,C1CCOC1,CCOCC,,val
US20120322811A1,CON(C)C(=O)C(C)(C)NC(=O)OC(C)(C)C>>CC(C)(C=O)NC(=O)OC(C)(C)C,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20020156081A1,COc1cc(-c2nn(CCO)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C.CS(=O)(=O)Cl>>COc1cc(-c2nn(CCOS(C)(=O)=O)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C,,c1ccncc1,,,,val
US20110092544A1,CCOC(=O)c1c(N)nc(C)c(-c2c(F)cc(F)cc2F)c1-c1cc(OC)cc(OC)c1>>COc1cc(OC)cc(-c2c(C(=O)O)c(N)nc(C)c2-c2c(F)cc(F)cc2F)c1,,CCO,,[Na+].[OH-],,val
US05298652,CCCCCCCCCCCCCCCCCCOc1cc(OCc2ccccc2)cc(C(=O)N(CC(=O)O)CC(=O)O)c1>>CCCCCCCCCCCCCCCCCCOc1cc(O)cc(C(=O)N(CC(=O)O)CC(=O)O)c1,[Pd],C1CCOC1,,[H][H],,val
US20160039808A1,Oc1ccccc1.Oc1nc(Cl)nc2cnccc12>>Oc1nc(Oc2ccccc2)nc2cnccc12,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05569655,ClCc1cccc2ccccc12.c1c[nH]cn1>>c1ccc2c(Cn3ccnc3)cccc2c1,,ClCCl,,O,,val
US20070197512A1,COC(=O)CCN1C(=O)C(C(C)C)Oc2ccccc21>>CC(C)C1Oc2ccccc2N(CCC(=O)O)C1=O,,CO,,[Na+].[OH-],,val
US05258396,CC(C(=O)CCl)c1ccc(-c2ccccc2)c(F)c1.CCOC(=O)CC(=O)OCC>>CCOC(=O)C(CC(=O)C(C)c1ccc(-c2ccccc2)c(F)c1)C(=O)OCC,,CN(C)C=O,,[H-].[Na+],,val
US20080261999A1,CC(C)(C)OC(=O)N1CC2C=C(c3cc(F)cc(F)c3)CC(C2)C1>>CC(C)(C)OC(=O)N1CC2CC(CC(c3cc(F)cc(F)c3)C2)C1,[Pd],CO,,,,val
US20020193367A1,CC(C)CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3ncnc3COC3CCCCO3)c2)cc1Cl>>CC(C)CN(C)c1cc2c(cc1Cl)NC(=O)CC(c1cccc(-n3ncnc3CO)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120022082A1,CC(C)(C)[Si](C)(C)OCCCc1ccc(-c2cnc(N)c(C(=O)Nc3cccnc3)n2)cc1>>Nc1ncc(-c2ccc(CCCO)cc2)nc1C(=O)Nc1cccnc1,,O,,C1CCOC1,[Na+].[OH-],val
US20100068771A1,NC[C@@H](O)c1ccc(Cl)cc1>>NC[C@H](O)c1ccc(Cl)cc1,,CCO,,,,val
US03940394,CCOC(=O)CSc1nc(Cl)cc(Nc2cccc(C)c2C)n1.NN>>Cc1cccc(Nc2cc(Cl)nc(SCC(=O)NN)n2)c1C,,O,,CCO,,val
US20050070556A1,CC(=O)OC[C@H]1O[C@@H](n2c(=O)sc3c(=O)[nH]c(N)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O.OCCC1CC1>>CC(=O)OC[C@H]1O[C@@H](n2c(=O)sc3c(OCC4CC4)nc(N)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06066733,CCOc1ccnc(Cl)n1.COC(CO)OC>>CCOc1ccnc(OCC(OC)OC)n1,,CN(C)C=O,,CC(=O)O,[H-].[Na+],val
US05122523,CC(C)(C)OC(=O)C(Cc1cccc2c1OCCO2)C(=O)[O-]>>CC(C)(C)OC(=O)C(CO)Cc1cccc2c1OCCO2,,CCO,CCOC(C)=O,[BH4-].[Na+],,val
US20160255837A1,CCSc1cc(OCc2ccc(OC)cc2)cnc1C(=O)O.CNc1cnc(C(F)(F)F)cc1N>>CCSc1cc(OCc2ccc(OC)cc2)cnc1C(=O)Nc1cc(C(F)(F)F)ncc1NC,,c1ccncc1,,CCN=C=NCCCN(C)C,Cl,val
US05721248,CC=Cc1cccc(C(C)=O)c1O.O=Cc1ccccc1>>CC=Cc1cccc(C(=O)C=Cc2ccccc2)c1O,,CCO,CO,Cl,[Na+].[OH-],val
US04592866,CCN1CC(CCCl)N(C)c2ccccc2C1=O.CNC>>CCN1CC(CCN(C)C)N(C)c2ccccc2C1=O,,CCO,,,,val
US20040176410A1,Cl.N#Cc1ccc(CCN2CCC(O)(COc3ccc(O)cc3)CC2)cc1>>Cl.N#Cc1ccc(CCN2CCC(O)(COc3ccc(O)cc3)CC2)cc1,,CO,,,,val
US20100249075A1,CCOC(=O)CC1=C(c2cccc(OC)c2)CCCC1>>CCOC(=O)CC1CCCCC1c1cccc(OC)c1,[Pd],C1CCOC1,,CCO,,val
US20080021217A1,CC(C)(C)OC(=O)NC1CCN(C(=O)Cc2nc(-c3ccncc3)n[nH]2)C1>>NC1CCN(C(=O)Cc2nc(-c3ccncc3)n[nH]2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060106045A1,C=CC(O)c1ccc(OC)cc1.O=S(Cl)Cl>>COc1ccc(/C=C/CCl)cc1,,CCOCC,,,,val
US20080146625A1,CS(=O)(=O)c1ccc(/C(=N\OC2CCCC2)C(=O)O)cc1Cl.Nc1nc2ccccc2s1>>CS(=O)(=O)c1ccc(/C(=N\OC2CCCC2)C(=O)Nc2nc3ccccc3s2)cc1Cl,,CC#N,,CCN(C(C)C)C(C)C,,val
US20100222396A1,CN(C(=O)c1ccccc1)[C@H](CC#N)Cc1ccccc1>>CN(C(=O)c1ccccc1)[C@H](CCN)Cc1ccccc1,[Ni],CO,,,,val
US20150266867A1,CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)N(CCCNC(=O)OC(C)(C)C)Cc1cnn(C[C@@H]2[C@H](NC(=O)/C(=N\OC3(C(=O)OC(c4ccccc4)c4ccccc4)CC3)c3csc(NC(=O)OC(C)(C)C)n3)C(=O)N2S(=O)(=O)O)n1>>N=C(N)N(CCCN)Cc1cnn(C[C@@H]2[C@H](NC(=O)/C(=N\OC3(C(=O)O)CC3)c3csc(N)n3)C(=O)N2S(=O)(=O)O)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05506219,CC(=O)C(c1ccccc1)c1ccccc1.O=Cc1ccc(F)cc1>>O=C(C=Cc1ccc(F)cc1)C(c1ccccc1)c1ccccc1,,CCO,,C,C[O-].[Na+],val
US20040147543A1,CCOCc1nc2c(N)nc3cc(-c4cccnc4)ccc3c2n1CCN.CS(=O)(=O)Cl>>CCOCc1nc2c(N)nc3cc(-c4cccnc4)ccc3c2n1CCNS(C)(=O)=O,,ClC(Cl)Cl,,CCN(CC)CC,O,val
US20040204590A1,O=C1CC[C@H](CO)N1CCCCCl>>O=C[C@H]1CCC(=O)N1CCCCCl,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US04460777,CN.COC(=O)CCCCCCCn1c(-c2cccnc2)c(C)c2ccccc21>>CNC(=O)CCCCCCCn1c(-c2cccnc2)c(C)c2ccccc21,,CCCCO,,,,val
US20040122002A1,Clc1ccc(CC2=NCCC2)cc1.O=C(CBr)c1ccccc1>>Clc1ccc(-c2c(-c3ccccc3)cn3c2CCC3)cc1,,CO,,O=C([O-])O.[Na+],,val
US04957928,CCOC(=O)C1=CCCNC1.Cc1ccc(S(=O)(=O)OCCC2COc3ccccc3C2)cc1>>CCOC(=O)C1=CCCN(CCC2COc3ccccc3C2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20070082908A1,COCn1nc(C(=O)N[C@@H](C(=O)CC(=O)OC)C(=O)OC)c(Cc2ccccc2Cl)c1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1.Cl>>COC(=O)Cc1c(C(=O)OC)[nH]c(=O)c2c(Cc3ccccc3Cl)c(N3CCC[C@@H](N)C3)nn12.Cl,,C1COCCO1,Cl,O,,val
US20150284423A1,Clc1ccccn1.OCc1ccc(Br)cc1>>Brc1ccc(COc2ccccn2)cc1,C1COCCOCCOCCOCCOCCO1,Cc1ccccc1,,O,[K+].[OH-],val
US20120129842A1,CC(C)Oc1ccc(C(N)=O)cc1[N+](=O)[O-].S=C(Cl)Cl>>CC(C)Oc1ccc(C(N)=O)cc1N=C=S,,ClC(Cl)Cl,O,O=C([O-])O.[Na+],,val
US20150158847A1,COc1cc(CNC(=O)OC(C)(C)C)ccc1OCc1ccc(C(F)F)nc1>>COc1cc(CN)ccc1OCc1ccc(C(F)F)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080316679A1,CCN(C)C.O=C(O)c1ccccc1C(=O)O>>CC[NH+](C)C.O=C([O-])c1ccccc1C(=O)[O-],,CO,,,,val
US20130072467A1,CNC(=O)CNC1=NC(=O)SC1.O=CC1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1>>CNC(=O)CNC1=NC(=O)S/C1=C\C1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1,,CC(C)O,,C1CC[NH2+]CC1.CC(=O)[O-],,val
US04716169,COc1cc(S(N)(=O)=O)ccc1-c1cn2nc(Cl)ccc2n1>>COc1cc(S(N)(=O)=O)ccc1-c1cn2ncccc2n1,[Pd],,,[H][H],,val
US05082847,COC(CC(=O)O)OC.COc1ccc(OC(C)=O)cc1N>>COc1ccc(OC(C)=O)cc1NC(=O)CC(OC)OC,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150005280A1,CCOC(=O)C1CCCC(N)C1>>NC1CCCC(CO)C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090275592A1,CC(C)(C)OC(=O)N[C@H](CCc1nnc(-c2ccc3cnccc3c2)o1)Cc1ccc(C(F)(F)F)cc1>>N[C@H](CCc1nnc(-c2ccc3cnccc3c2)o1)Cc1ccc(C(F)(F)F)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080004274A1,COC(=O)c1ccc(CCSc2ccc3c(c2)C(=O)C(=O)N3CCc2ccccc2)cc1.NNC(=O)Nc1ccc(F)cc1>>COC(=O)c1ccc(CCSc2ccc3c(c2)C(=NNC(=O)Nc2ccc(F)cc2)C(=O)N3CCc2ccccc2)cc1,,CC(=O)O,CO,Cl,,val
US20160009683A1,CCOC(=O)C(F)(F)c1cccc(O)c1.COCCOCCO>>CCOC(=O)C(F)(F)c1cccc(OCCOCCOC)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110166129A1,CN.COC(=O)c1ccc(Cl)nc1CCl>>CN1Cc2nc(Cl)ccc2C1=O,,O,,C1CCOC1,,val
US20120122840A1,COc1cc(N2CCNCC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1.NC(=O)CBr>>COc1cc(N2CCN(CC(N)=O)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20050070521A1,BrBr.COc1cc(O)c(C(C)=O)cc1CCO>>COc1cc(O)c(C(=O)CBr)cc1CCO,,ClCCl,,,,val
US20070129354A1,COC(=O)c1ccc(Br)c(O)c1.CS(=O)(=O)NCCI>>COC(=O)c1ccc(Br)c(OCCNS(C)(=O)=O)c1,,CN(C)C=O,,[H-].[Na+],,val
US20050096353A1,COCCc1nc(-c2ccc(C(F)(F)F)cc2)ncc1CO.O=S(Cl)Cl>>COCCc1nc(-c2ccc(C(F)(F)F)cc2)ncc1CCl,,CCOCC,ClCCl,,,val
US20110263602A1,CCOC(=O)c1cnn(C)c1N.CSSC>>CCOC(=O)c1cnn(C)c1SC,,ClC(Cl)Cl,,CC(C)CCON=O,,val
US06492355B1,CC(C)(C)OC(=O)N1CCC(=O)CC1.COP(=O)(Cc1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1)OC>>CC(C)(C)OC(=O)N1CCC(=Cc2ccc(Cl)c(C(=O)NCC34CC5CC(CC(C5)C3)C4)c2)CC1,,C1CCOC1,O,CC(C)[N-]C(C)C.[Li+],,val
US06525067B1,CCC(=O)c1nc(C)nc2c1COCN2c1c(C)cc(C)cc1C.NO>>CC/C(=N/O)c1nc(C)nc2c1COCN2c1c(C)cc(C)cc1C,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20140349993A1,CCOC(=O)c1cnc2ccc(Cl)nn12.FC(F)(F)C1CCCN1>>CCOC(=O)c1cnc2ccc(N3CCCC3C(F)(F)F)nn12,,O,,,,val
US04933355,CCOC(=O)C(=O)CBr.NC(=S)Nc1ccccc1>>CCOC(=O)c1csc(Nc2ccccc2)n1,,CCO,,,,val
US20160176850A1,CC(C)(C)OC(=O)N1CCC(COc2cccnc2N)CC1>>Nc1ncccc1OCC1CCNCC1,,CCOC(C)=O,ClCCl,Cl,,val
US20130317026A1,CC(C)(C)OC(=O)N1CCC(Br)CC1.Cc1cc(C)c(CNC(=O)c2cc(Br)nc3[nH]ncc23)c(=O)[nH]1>>Cc1cc(C)c(CNC(=O)c2cc(Br)nc3c2cnn3C2CCN(C(=O)OC(C)(C)C)CC2)c(=O)[nH]1,,CN(C)C=O,ClCCl,O,O=C([O-])[O-].[K+].[K+],val
US20090163524A1,CC(C)(C)OC(=O)NC1(C(=O)NC(CC(N)=O)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1>>NC(=O)CC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1,,ClCCl,,C1COCCO1,Cl,val
US20160060260A1,COCCCOc1cc(O)cc(O)c1.FC(F)(F)CI>>COCCCOc1cc(O)cc(OCC(F)(F)F)c1,,CCOC(C)=O,CN(C)C=O,[I-].[K+],,val
US20040105821A1,CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC>>CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.O=C([O-])O.[NH4+],,ClCCl,,,,val
US20060252750A1,Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc(C)c1OCc1ccccc1>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc(C)c1O,[Pd],ClCCl,,[H][H],,val
US20100137281A1,CCc1cc2c(=O)n(CCn3ccnc3C=O)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1>>CCc1cc2c(=O)n(CCn3ccnc3CO)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1,,CO,,[BH4-].[Na+],,val
US20150175583A1,Cl.N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5oc(C(N)=O)cc5c4)CC3)c2c1.OCc1ccccc1>>Cl.N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5oc(C(N)=O)cc5c4)CC3)c2c1.OCc1ccccc1,,CN(C)C=O,,CC(C)O,,val
US20130146851A1,CC(C)N=C=O.CCCC(C)n1ccc2cc(O)ccc21>>CCCC(C)n1ccc2cc(OC(=O)NC(C)C)ccc21,,ClCCl,,CCN(CC)CC,,val
US04185115,BrCCc1cccc2ccccc12.CCOC(=O)c1ccc(N)cc1>>CCOC(=O)c1ccc(NCCc2cccc3ccccc23)cc1,,CN(C)P(=O)(N(C)C)N(C)C,,,,val
US20150126498A1,COc1cc(N)cnc1OC.COc1ccc(NS(=O)(=O)c2cccnc2Cl)nc1OC.O=S(=O)(Cl)c1cccnc1Cl.c1ccncc1>>COc1cc(NS(=O)(=O)c2cccnc2Cl)cnc1OC.COc1cc(NS(=O)(=O)c2cccnc2N)cnc1OC,,C1CCOC1,c1ccncc1,,,val
US05837711,CI.COc1ccc(NC(C)=O)cc1C1OCCO1>>COc1ccc(N(C)C(C)=O)cc1C1OCCO1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US04764521,CCCc1c(O)cccc1OCCCCc1nnn[nH]1.O=S(=O)(Cl)Cl>>CCCc1c(OCCCCc2nnn[nH]2)ccc(Cl)c1O,,C1CCOC1,,,,val
US20030069223A1,CC(=O)CN.O=C(Cl)[C@@H]1CCCN1C(=O)C(F)(F)F>>CC(=O)CNC(=O)C1CCCN1C(=O)C(F)(F)F,,ClCCl,c1ccncc1,,,val
US20130203727A1,CCOC(=O)C(OC(C)(C)C)c1c(C)cc2ccccc2c1OS(=O)(=O)C(F)(F)F>>CCOC(=O)C(O)c1c(C)cc2ccccc2c1OS(=O)(=O)C(F)(F)F,,ClCCl,O,O=C(O)C(F)(F)F,,val
US05082954,CCCCCCCCCCCCC(O)c1coc([Si](C)(C)C)c1.O=C(Cl)C1CCCCC1>>CCCCCCCCCCCCC(OC(=O)C1CCCCC1)c1coc([Si](C)(C)C)c1,,C1CCOC1,CCCCC,[Li]C(C)(C)C,,val
US20070066624A1,CC(C)(C)N.CC(C)(C)OC(=O)NC(C(=O)O)c1cccc(Cl)c1>>CC(C)(C)NC(=O)C(NC(=O)OC(C)(C)C)c1cccc(Cl)c1,,C1CCOC1,,CN1CCOCC1,,val
US04593102,COCCO.O=S(=O)(c1ccc(Cl)cc1)C1CCCNC1>>COCCOc1ccc(S(=O)(=O)C2CCCNC2)cc1.Cl,,CS(C)=O,,[H-].[Na+],,val
US04835315,CC(C)(C)N.O=C(CCl)c1ccc(F)cc1>>CC(C)(C)NCC(O)c1ccc(F)cc1,,CO,,CC(=O)O,[BH4-].[Na+],val
US20140038926A1,Fc1cc(C(F)(F)F)ccn1.SCc1ccccc1>>FC(F)(F)c1ccnc(SCc2ccccc2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090286782A1,O=S(=O)(c1ccccc1)n1cc(Cc2ccc(NCc3ccc(C(F)(F)F)nc3)nc2)c2c(C3CCCC3)ncnc21>>FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncnc(C5CCCC5)c34)cn2)cn1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150057271A1,N#Cc1cc(C(F)(F)F)ccc1N1CCOc2c(F)cccc21.O=S(=O)(O)Cl>>N#Cc1cc(C(F)(F)F)ccc1N1CCOc2c1ccc(S(=O)(=O)Cl)c2F,,ClCCl,,,,val
US04140515,COC(=O)c1ccccc1C1=NOC(c2ccccn2)C1>>COC(=O)c1ccccc1-c1cc(-c2ccccn2)on1,,Clc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20020119999A1,CC(C)(C)OC(=O)NC[C@H](NC(=O)OCc1ccccc1)C(=O)OC(C)(C)C.Cl>>CC(C)(C)OC(=O)NC[C@H](N)C(=O)OC(C)(C)C.Cl,[Pd],,,CO,,val
US20110195954A1,Brc1cnc2ccccc2c1.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1cc(Br)cc2ccccc21,,ClCCl,,,,val
US20130059834A1,O=CNCc1ccc(F)cn1>>Fc1ccc2cncn2c1,,Cc1ccccc1,,O=P(Cl)(Cl)Cl,,val
US20060111362A1,CC(C)(C)OC(=O)N1CCN(c2ncnc3[nH]cnc23)CC1.CI>>Cn1cnc2c(N3CCN(C(=O)OC(C)(C)C)CC3)ncnc21,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20070004675A1,CC1(C)OC(=O)CC(=O)O1.Nc1ccccc1F>>O=C(O)CC(=O)Nc1ccccc1F,,ClCCl,,C[Si](C)(C)Cl,,val
US20080176830A1,N#CCBr.O=C1CNc2cc(-c3ccc(C(F)(F)F)cc3)ccc2N1>>N#CCN1CC(=O)Nc2ccc(-c3ccc(C(F)(F)F)cc3)cc21,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US05637593,CN1CCC(=O)CC1.c1ccc(Sc2ccc3[nH]ccc3c2)nc1>>CN1CC=C(c2c[nH]c3ccc(Sc4ccccn4)cc23)CC1,,CO,ClCCl,C[O-].[Na+],,val
US07037932B2,N#Cc1cc2c(F)ccc(O)c2s1.O[C@H](CCI)c1ccccc1>>N#Cc1cc2cccc(O[C@@H](CCI)c3ccccc3)c2s1,,C1CCOC1,,,,val
US05221685,N#Cc1ccc(C(=O)Cl)cc1.N=C1NC(C(F)(F)F)(C(F)(F)F)C(=C(F)C(F)(F)F)S1>>N#Cc1ccc(C(=O)NC2=NC(C(F)(F)F)(C(F)(F)F)C(=C(F)C(F)(F)F)S2)cc1,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US20140051676A1,BrCc1ccccc1.CN(c1ccccc1)c1nc(N)nc(-c2noc(C3CCNCC3)n2)n1>>CN(c1ccccc1)c1nc(N)nc(-c2noc(C3CCN(Cc4ccccc4)CC3)n2)n1,,CN(C)C=O,ClCCl,Cl,[H-].[Na+],val
US20150376212A1,O=S(=O)(c1ncccc1Br)C1CCNCC1.OCCBr>>O=S(=O)(c1ncccc1Br)C1CCN(CCO)CC1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20160159752A1,C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H](CCc2c(F)cncc2NC(=O)[C@@H](N)[C@@H](c2ccc(F)cc2)c2cc(F)cc(F)c2)N1S(=O)(=O)C1CC1>>C[C@@H]1CNC[C@H](CCc2c(F)cncc2NC(=O)[C@@H](N)[C@@H](c2ccc(F)cc2)c2cc(F)cc(F)c2)N1S(=O)(=O)C1CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050261327A1,Br[Mg]c1ccccc1.O=C1CCC2(CC1)OCCO2>>OC1(c2ccccc2)CCC2(CC1)OCCO2,,C1CCOC1,,,,val
US20100004300A1,CC(C)(C)[Si](O[C@H]1CCOC1=O)(c1ccccc1)c1ccccc1.Nc1ccc(S(=O)(=O)Nc2nccs2)cc1>>CC(C)(C)[Si](O[C@@H](CCO)C(=O)Nc1ccc(S(=O)(=O)Nc2nccs2)cc1)(c1ccccc1)c1ccccc1,,ClCCl,,C[Al](C)C,,val
US20100210690A1,ClCc1cccnc1.O=C1c2ccccc2C(=O)N1c1cc[nH]n1>>Nc1ccn(Cc2cccnc2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20150141406A1,N#CCc1ccc(-c2nn(-c3c(F)cccc3F)c3cc[nH]c(=O)c23)cc1.OO>>NC(=O)Cc1ccc(-c2nn(-c3c(F)cccc3F)c3cc[nH]c(=O)c23)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090149456A1,O=C(Cc1cccs1)Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc4c(c3)N(C(=O)C(F)(F)F)CCC4)n2)c1>>O=C(Cc1cccs1)Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc4c(c3)CNCC4)n2)c1,,CO,,[Li+].[OH-],,val
US20120065197A1,CCOC(=O)c1cccc(N2CCN(C(=O)Cn3nc(C(F)F)cc3C(F)F)CC2)n1>>O=C(O)c1cccc(N2CCN(C(=O)Cn3nc(C(F)F)cc3C(F)F)CC2)n1,,C1CCOC1,O,[Li+].[OH-],,val
US20050124555A1,C1CCNC1.CC(=O)Cc1ccc(OCc2ccccc2)c(Br)c1.CCOCC>>Brc1cc(Cc2cc3cccccc-3c2)ccc1OCc1ccccc1,,CCOCC,,O=S(=O)([O-])[O-].[Mg+2],,val
US06218431B1,CCCC=Cc1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccc(F)cc1>>CCCCCc1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccc(F)cc1,[Pd],CCO,,,,val
US20140323464A1,CC(C)(C=C(C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1)CO[Si](C)(C)C(C)(C)C>>CC(C)(C=C(C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1)CO,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US08435985B2,C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc(F)c(C#N)c3)nc2n1>>C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3cccc(N)c3)nc2n1,,CCO,,NN,O,val
US20130296290A1,CC(C)(C)OC(=O)NC1(CCO[Si](C)(C)C(C)(C)C)CC1>>CC(C)(C)OC(=O)NC1(CCO)CC1,,ClCCl,,,,val
US20160251380A1,CN(C)C=O.Fc1ccc(OCCOCc2ccccc2)c(Br)c1>>O=Cc1c(F)ccc(OCCOCc2ccccc2)c1Br,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20100286114A1,CC(C)(C)OC(=O)N1CCN(c2cccc(-c3nc4ccccc4[nH]3)c2)CC1.CI>>Cn1c(-c2cccc(N3CCN(C(=O)OC(C)(C)C)CC3)c2)nc2ccccc21,,C1CCOC1,O,Cl,[H-].[Na+],val
US20160235716A1,C#C[Si](C)(C)C.O=Cc1cccs1>>C[Si](C)(C)C#CC(O)c1cccs1,,C1CCOC1,,[Li]CCCC,,val
US20150175562A1,CC(C)(C)c1cc(C(=O)C(Br)CC2CCCCC2)cc(C(C)(C)C)c1.NC=O.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CC(C)(C)c1cc(-c2ncsc2CC2CCCCC2)cc(C(C)(C)C)c1,,C1COCCO1,,Cl,,val
US20110213156A1,CC(C)c1cc(C(=O)O)oc1C(C)C.[Li]C>>CC(=O)c1cc(C(C)C)c(C(C)C)o1,,CCOCC,,[Cl-].[NH4+],,val
US20030100554A1,BrBr.CCc1nn(CCNC(=O)OC(C)(C)C)c(CO)c1Oc1cc(Cl)cc(Cl)c1>>CCc1nn(CCNC(=O)OC(C)(C)C)c(CBr)c1Oc1cc(Cl)cc(Cl)c1,,ClCCl,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100056542A1,CCOC(=O)C(F)(F)Sc1nccn1-c1ccc(C#N)c2ccccc12.O=C1CCC(=O)N1Br>>CCOC(=O)C(F)(F)Sc1ncc(Br)n1-c1ccc(C#N)c2ccccc12,,ClCCl,,,,val
US20080255180A1,NN.O=C(O)c1c[nH]c2ccccc12>>NNC(=O)c1c[nH]c2ccccc12,,C1CCOC1,,O,O=S(Cl)Cl,val
US20150141406A1,CC1(C)OB(c2csc(CC#N)c2)OC1(C)C.COC1NC=C(C#N)c2c1c(Br)cn2C1CCCC1>>COc1ncc(C#N)c2c1c(-c1csc(CC#N)c1)cn2C1CCCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20120142665A1,Cc1cc(C)c(S(=O)(=O)ON)c(C)c1.Nc1cc(Br)ccn1>>Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1.Nc1cc(Br)cc[n+]1N,,CCOCC,ClCCl,,,val
US05811389,COc1ccc2c(c1CNC(=O)OC(C)(C)C)Oc1c(ccc(OC)c1CC(=O)O)C2(C)C.OCc1ccccc1>>COc1ccc2c(c1CNC(=O)OC(C)(C)C)Oc1c(ccc(OC)c1CC(=O)OCc1ccccc1)C2(C)C,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04025641,CC(C)CCOCCCCBr.OCCCCCCO>>CC(C)CCOCCCCOCCCCCCO,,COCCOC,,CCOCC,[H-].[Na+],val
US20060079519A1,C#Cc1cccnc1.Cc1cc(C(=O)O)cc(N=[N+]=[N-])c1C>>Cc1cc(C(=O)O)cc(-n2cc(-c3cccnc3)nn2)c1C,,CCO,,,,val
US20150361100A1,CC(c1cc2ccccn2c1CN1C[C@H]2CN(C(=O)OC(C)(C)C)C[C@H]2C1)n1nc(I)c2c(N)ncnc21.OB(O)c1cc(O)cc(F)c1>>CC(c1cc2ccccn2c1CN1C[C@H]2CN(C(=O)OC(C)(C)C)C[C@H]2C1)n1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US04308208,CI.COC(=O)C(SC)c1cccc(C(=O)c2ccccc2)c1>>COC(=O)C(C)(SC)c1cccc(C(=O)c2ccccc2)c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20140303070A1,C=CCSSCC=C.CC1(C)OO1>>C=CCSS(=O)CC=C,,CC(C)=O,,,,val
US20100249119A1,CC(C)(C)OC(=O)CCl.CN1CCNCC1>>CN1CCN(CC(=O)OC(C)(C)C)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160022640A1,BrCC1CCCN1Cc1ccccc1.CC1=NN(c2ccccc2)C(=O)C1>>Cc1cc(OCC2CCCN2Cc2ccccc2)n(-c2ccccc2)n1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040006141A1,CCOC(=O)C(Cc1ccc(OCCNC(=O)c2ccc(-c3ccccn3)cc2)cc1)Nc1ccccc1>>O=C(NCCOc1ccc(CC(Nc2ccccc2)C(=O)O)cc1)c1ccc(-c2ccccn2)cc1,,CO,,[Na+].[OH-],,val
US20130089512A1,C[Si](C)(C)CCOCCl.O=c1[nH]c2cnc(Cl)nc2n1C1CCOCC1>>C[Si](C)(C)CCOCn1c(=O)n(C2CCOCC2)c2nc(Cl)ncc21,,CN(C)C=O,,[H-].[Na+],,val
US04988699,O=C(O)CC1CCC2(CC1)OCCO2.c1ccc(N2CCNCC2)nc1>>O=C(CC1CCC2(CC1)OCCO2)N1CCN(c2ccccn2)CC1,,ClCCl,,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20100105657A1,O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=[N+]([O-])c1ccc2c(c1)CNCCO2>>O=C(N1CCOc2ccc([N+](=O)[O-])cc2C1)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US06235771B1,CCCOCCCl.Oc1ccc2occc2c1>>CCCOCCOc1ccc2occc2c1,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20080045528A1,CNC(=O)c1cc(Oc2ccc3nc(S(C)=O)oc3c2)ccn1.N[C@@H]1CCCC[C@H]1O>>CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)oc3c2)ccn1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,Cl,val
US20110118251A1,Cc1nn(-c2ncccc2CO)cc1CN1CCC2(CC1)OCC(F)(F)c1cc(Cl)sc12.O=C1NC(=O)c2ccccc21>>Cc1nn(-c2ncccc2CN2C(=O)c3ccccc3C2=O)cc1CN1CCC2(CC1)OCC(F)(F)c1cc(Cl)sc12,,Cc1ccccc1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04918073,O=S(Cl)Cl.OCCC1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1>>Fc1ccc(C(CCCN2CCC(CCCl)CC2)c2ccc(F)cc2)cc1,,ClCCl,,,,val
US20090270435A1,Cc1cc2c(cc1Cl)C(=O)CC1(CCN(C(=O)OC(C)(C)C)CC1)O2.Cl>>Cc1cc2c(cc1Cl)C(=O)CC1(CCNCC1)O2.Cl,,C1COCCO1,CO,,,val
US20040077669A1,C#CCOc1cc(Cl)ncn1.Cc1cccc(O)c1>>C#CCOc1cc(Oc2cccc(C)c2)ncn1,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20080171772A1,CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2cc(F)c(I)cc2n1Cc1ccccc1.CO>>COc1cc2c(cc1F)c(C(=O)NCc1ccc(F)c(F)c1)c(C(C)C)n2Cc1ccccc1,[Cu]I,CN(C)C=O,,[Na],C[O-].[Na+],val
US03974161,N#CCC(N)=O.Nc1ccccc1C=O>>NC(=O)c1cc2ccccc2nc1N,,CCO,,C,C[O-].[Na+],val
US20140031338A1,COC(=O)C(OC(C)(C)C)c1ccccc1-c1ccc2c(c1)CCCO2>>CC(C)(C)OC(C(=O)O)c1ccccc1-c1ccc2c(c1)CCCO2,,CCO,O,[K+].[OH-],,val
US20130197039A1,COC[C@@H](O)CN.Fc1ccc(F)nc1>>COC[C@H](CN)Oc1ccc(F)cn1,,CC(=O)N(C)C,,[H-].[Na+],,val
US04629736,CCCCCCCCCCCCCCNC(=O)[C@H](CC(=O)OCc1ccccc1)NC(=O)CCCCCNC(=O)CCCCCNS(C)(=O)=O>>CCCCCCCCCCCCCCNC(=O)[C@H](CC(=O)O)NC(=O)CCCCCNC(=O)CCCCCNS(C)(=O)=O,,CO,,,,val
US20130059830A1,CC(C)(C)OC(=O)N1CC(c2cc(-c3ccc(F)cc3)nn2-c2ncccn2)CCC1CCc1ccccc1>>Fc1ccc(-c2cc(C3CCC(CCc4ccccc4)NC3)n(-c3ncccn3)n2)cc1,,ClCCl,,Cl,,val
US20070185111A1,CNc1nccc(-c2cccnc2Oc2ccc(O)cc2)n1.Clc1nnc(-c2ccccc2)c2ccccc12>>CNc1nccc(-c2cccnc2Oc2ccc(Oc3nnc(-c4ccccc4)c4ccccc34)cc2)n1,,CO,CS(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20120329649A1,O=C1CCc2cc(/C=C/C(c3cc(Cl)c(Cl)c(Cl)c3)C(F)(F)F)ccc21.[NH4+]>>NC1CCc2cc(/C=C/C(c3cc(Cl)c(Cl)c(Cl)c3)C(F)(F)F)ccc21,,CO,,[BH3-]C#N.[Na+],,val
US04492711,CN(C)Cc1ccc(CSCCNC(=O)c2cccc([N+](=O)[O-])c2)o1>>CN(C)Cc1ccc(CSCCNC(=O)c2cccc(N)c2)o1,[Fe],,,,,val
US06005116,NCCOc1cc(-c2ccccc2)on1.O=C(Cl)c1ccccc1>>O=C(NCCOc1cc(-c2ccccc2)on1)c1ccccc1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20090156600A1,CCC(=O)C(Cc1ccc(F)cc1Cl)C(=O)OC.COC(=O)COc1ccc(F)c(N)c1>>CCc1[nH]c2c(F)ccc(OCC(=O)OC)c2c(=O)c1Cc1ccc(F)cc1Cl,,O,,C1COCCO1,,val
US04818430,CCCc1ccc(-c2ccc(Cl)nn2)cc1.COc1ccc(Br)cc1>>CCCc1ccc(-c2ccc(-c3ccc(OC)cc3)nn2)cc1,Cl[Ni]Cl,C1CCOC1,,[Mg],,val
US20050288376A1,COc1ccc(C(CS(=O)(=O)Cc2ccc3occc3c2)N(C=O)OC(=O)[C@@H](OC)c2ccccc2)cc1>>COc1ccc([C@@H](CS(=O)(=O)Cc2ccc3occc3c2)N(O)C=O)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US04078933,NC(=O)Nc1ccc(S(=O)(=O)O)cc1.O=C(O)CC(=O)O.[K]>>O=C1CC(=O)N(c2ccc(S(=O)(=O)O)cc2)C(=O)N1.[K],,CC(=O)O,,CC(=O)OC(C)=O,,val
US20090042852A1,CCc1cnc(-c2cnc(Cl)c(Cl)c2)o1.CI>>CCc1cnc(-c2cnc(Cl)c(Cl)c2C)o1,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20040214817A1,Nc1ccc(Oc2ccccc2)cc1.Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)n[nH]1.S=C(n1ccnc1)n1ccnc1>>Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=S)Nc1ccc(Oc2ccccc2)cc1,,CC#N,CN(C)C=O,c1c[nH]cn1,,val
US04929613,CCOC=C(C(=O)OCC)C(=O)c1cc(F)c(C2CCC(NC(C)=O)C2)cc1F.NC1CC1>>CCOC(=O)C(=CNC1CC1)C(=O)c1cc(F)c(C2CCC(NC(C)=O)C2)cc1F,,CCO,,,,val
US06177440B1,COC(=O)COc1cccc2c1c1c(C(N)=O)cccc1n2CC1CCCCC1>>NC(=O)c1cccc2c1c1c(OCC(=O)O)cccc1n2CC1CCCCC1,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US20120053166A1,COc1ncc(-c2cc(-c3nnc(CN4CCCOCC4)o3)c3cnn(S(=O)(=O)c4ccccc4)c3c2)cc1NS(C)(=O)=O>>COc1ncc(-c2cc(-c3nnc(CN4CCCOCC4)o3)c3cn[nH]c3c2)cc1NS(C)(=O)=O,,C1COCCO1,,[Na+].[OH-],,val
US20070106103A1,OC1(c2ccc(-c3cccc4ccccc34)cc2)c2ccccc2C(O)(c2ccc(-c3cccc4ccccc34)cc2)c2cc(-c3ccccc3-c3ccccc3)ccc21>>c1ccc(-c2ccccc2-c2ccc3c(-c4ccc(-c5cccc6ccccc56)cc4)c4ccccc4c(-c4ccc(-c5cccc6ccccc56)cc4)c3c2)cc1,,C1CCOC1,,Cl,,val
US20110015196A1,C=C(C)[C@@H]1CCC2(C(=O)N3C4CCC3CC(n3c(C)nnc3C(C)C)C4)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CCC2(C(=O)N3C4CCC3CC(n3c(C)nnc3C(C)C)C4)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,CO,,C1CCOC1,[Na+].[OH-],val
US20060276536A1,CN.O=C(C=Cc1ccccc1)C=Cc1ccccc1>>CN1C(c2ccccc2)CC(=O)CC1c1ccccc1,,CN(C)C=O,,O,,val
US06506747B1,CCc1cc(-c2cccnc2)nn1-c1ccc(N)cc1.Cc1cccc(F)c1C#N>>CCc1cc(-c2cccnc2)nn1-c1ccc(NCc2c(C)cccc2F)cc1,[Ni],CC(=O)O,,,,val
US20090281073A1,CC(=O)Cl.Cc1cc(Nc2nc(N3CC4(CCNCC4)C3)nc3ncccc23)[nH]n1>>CC(=O)N1CCC2(CC1)CN(c1nc(Nc3cc(C)n[nH]3)c3cccnc3n1)C2,,CN(C)C=O,,,,val
US20160002225A1,CCO.CCOP(=O)(OCC)C(F)C(=O)[O-]>>CCOP(=O)(OCC)C(F)(CC)C(=O)O,,O,,Cl,[Na+].[OH-],val
US20080045526A1,CCC1OC(=O)c2ccncc21.O=C1Cc2cc(F)ccc2N1>>CCC1OC(=C2C(=O)Nc3ccc(F)cc32)c2ccncc21,,C1CCOC1,,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US04070362,CCCCNc1c(N)c(N)nc(C)c1C(=O)OCC.O=N[O-]>>CCCCNc1c(C(=O)OCC)c(C)nc2[nH]nnc12,,O,,CC(=O)O,,val
US20100035883A1,CCOC(OCC)c1cccc(C=O)c1.Nc1cccc2c1COC2=O>>CCOC(OCC)c1cccc(/C=N/c2cccc3c2COC3=O)c1,,ClCCl,,O=S(=O)([O-])[O-].[Na+].[Na+],,val
US20060025455A1,Nc1ccc(-c2ccc(Cl)cc2Cl)cn1.O=S(=O)(Cl)N1CCCCC1>>O=S(=O)(Nc1ccc(-c2ccc(Cl)cc2Cl)cn1)N1CCCCC1,,c1ccncc1,,,,val
US05482949,Cl.O=C(Nc1ccc(Cl)cc1)c1ccc(-c2sc3cc(C(=O)Nc4ccc(Cl)cc4)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1>>Cl.O=C(Nc1ccc(Cl)cc1)c1ccc(-c2sc3cc(C(=O)Nc4ccc(Cl)cc4)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1,,CCOCC,,C1CCOC1,,val
US06413995B1,COC(=O)CC(O)c1ccc(C=CC(=O)O)cc1.NCc1cccnc1>>COC(=O)CC(O)c1ccc(C=CC(=O)NCc2cccnc2)cc1,,CN(C)C=O,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US05182295,COc1ccc(C(=O)CBr)cc1.Oc1ccccc1Br>>COc1ccc(C(=O)COc2ccccc2Br)cc1,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130158025A1,CCOC(=O)CC(=O)c1ccc(F)c(F)c1.Cc1cc(N)[nH]n1>>Cc1cc2[nH]c(=O)cc(-c3ccc(F)c(F)c3)n2n1,,c1ccncc1,,,,val
US20030162240A1,CC(=O)Oc1cn(C(C)=O)c2ccc(Br)c(Cl)c12>>Oc1c[nH]c2ccc(Br)c(Cl)c12,,CN(C)C=O,,C[O-].[Na+],,val
US06020346,BrC1CCCC1.O=Cc1cc(-n2cnnn2)ccc1O>>O=Cc1cc(-n2cnnn2)ccc1OC1CCCC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04470976,CC(=O)OC[C@H]1O[C@@H](Sc2cccc(C(F)(F)F)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1O[C@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O>>OC[C@H]1O[C@@H](Sc2cccc(C(F)(F)F)c2)[C@H](O)[C@@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O,,CO,,,,val
US20130131039A1,CC#N.N#Cc1ccc(Br)cc1>>N#CC=C(N)c1ccc(Br)cc1,,C1CCOC1,O,CC(C)NC(C)C,[Li]CCCC,val
US20150376160A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4sc(F)cc4NC(=O)O[C@H](C)c4ccccc4Cl)cc3)cc2)CC1>>C[C@@H](OC(=O)Nc1cc(F)sc1-c1ccc(-c2ccc(C3(C(=O)O)CC3)cc2)cc1)c1ccccc1Cl,,CC(C)O,,Cl,[Na+].[OH-],val
US20120046271A1,N#Cc1cccc(Br)c1.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-]>>N#Cc1ccccc1.O=C(O)[C@H](O)[C@@H](O)C(=O)O,,CO,,,,val
US20100298557A1,Clc1nc(NC2CC2)c2cn[nH]c2n1.Nc1ccc(N2CCOCC2)cc1>>c1cc(N2CCOCC2)ccc1Nc1nc(NC2CC2)c2cn[nH]c2n1,,CCCCO,,,,val
US05710162,ClOCl.O=C1c2ccccc2-c2c1[nH]c(=O)c1ccccc21>>O=C1c2ccccc2-c2c1nc(Cl)c1ccccc21,,CN(C)C=O,,,,val
US05223536,O=Cc1cccc(Oc2ccccc2)n1>>OCc1cccc(Oc2ccccc2)n1,,CO,,[BH4-].[Na+],,val
US20120264737A1,CCc1cc(C2CCC2)c(C(=O)NN)cc1C(=O)N1CCC(F)(c2ccc(C#N)cc2)CC1.N#CBr>>CCc1cc(C2CCC2)c(-c2nnc(N)o2)cc1C(=O)N1CCC(F)(c2ccc(C#N)cc2)CC1,,C1COCCO1,O,O=C([O-])O.[Na+],,val
US20090275037A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.COc1ccc2c(c1)c(=O)nc(-c1ccccc1)n2C>>COc1ccc2c(c1)c(=S)nc(-c1ccccc1)n2C,,Cc1ccccc1,,,,val
US20080262056A1,CC(=O)OC(C)=O.NC[C@@H]1CN(c2cc(F)c3c(c2)CC(=O)N3CC2CC2)C(=O)O1>>CC(=O)NC[C@H]1CN(c2cc(F)c3c(c2)CC(=O)N3CC2CC2)C(=O)O1,,ClCCl,,c1ccncc1,,val
US20090143371A1,CC(C)N.Cc1onc(-c2cccc(F)c2)c1COc1ccc(C(=O)O)cn1>>Cc1onc(-c2cccc(F)c2)c1COc1ccc(C(=O)NC(C)C)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20100204224A1,CC(c1ccccc1Cl)N1CC2CC1CN2.O=C=Nc1ccc(Oc2ccccc2)cc1>>CC(c1ccccc1Cl)N1CC2CC1CN2C(=O)Nc1ccc(Oc2ccccc2)cc1,,CC#N,,,,val
US20120225869A1,CC(C)c1ccc(-c2nc3c(-c4ccccc4)n[nH]c3c(=O)n2-c2ccc(Cl)cc2)cc1.CN(C)C(=O)Cl>>CC(C)c1ccc(-c2nc3c(-c4ccccc4)nn(C(=O)N(C)C)c3c(=O)n2-c2ccc(Cl)cc2)cc1,,c1ccncc1,,,,val
US20080293718A1,CC(=O)N1CCc2ccc(-c3cccc(C4(c5ccccc5)N=C(N)N(C)C4=O)c3)cc2C1.Cl>>CC(=O)N1CCc2ccc(-c3cccc(C4(c5ccccc5)N=C(N)N(C)C4=O)c3)cc2C1.Cl,,ClCCl,,,,val
US04260779,CCOC(=O)C1C(=O)Sc2ccccc21.Nc1ccccc1>>O=C(Nc1ccccc1)C1C(=O)Sc2ccccc21,,Cc1ccccc1C,,,,val
US20070004772A1,Cc1cc(-c2ccc(Cl)cc2)c(Br)c2n[nH]c(=O)n12.Cc1nc(C(F)(F)F)ccc1CCl>>Cc1nc(C(F)(F)F)ccc1Cn1nc2c(Br)c(-c3ccc(Cl)cc3)cc(C)n2c1=O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20130217881A1,COC(=O)c1c(N)cccc1F.O=C(Cl)Cc1ccc(F)cc1>>COC(=O)c1c(F)cccc1NC(=O)Cc1ccc(F)cc1,CN(C)c1ccncc1,ClCCl,,O=C([O-])O.[Na+],,val
US20120225854A1,CC(=O)C(F)(F)F.O=S(=O)(c1ccccc1)N1CCN(c2ccc(Br)cc2)CC1>>CC(O)(c1ccc(N2CCN(S(=O)(=O)c3ccccc3)CC2)cc1)C(F)(F)F,,C1CCOC1,,[Li]CCCC,,val
US20120071461A1,Cc1cc(Cl)nc(C)n1.c1ccc(CN(CCC2CCNCC2)Cc2ccccc2)cc1>>Cc1cc(N2CCC(CCN(Cc3ccccc3)Cc3ccccc3)CC2)nc(C)n1,,CC(C)=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20140179733A1,CC(C)c1c(N)cnn1-c1ccc(F)cc1.Cc1c(Cl)c(C(F)(F)F)nn1C(C)(C)C(=O)O>>Cc1c(Cl)c(C(F)(F)F)nn1C(C)(C)C(=O)Nc1cnn(-c2ccc(F)cc2)c1C(C)C,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100137588A1,CCNCC.CN(C)[c-]1cccc1CO.[Fe+2].c1cc[cH-]c1>>CCN(CC)Cc1ccc[c-]1N(C)C.[Fe+2].c1cc[cH-]c1,,CC#N,ClCCl,C[Si](C)(C)Cl,[I-].[Na+],val
US20130158019A1,CCOC(=O)C1CCCNC1.Clc1ccnc(Cl)n1>>CCOC(=O)C1CCCN(c2ccnc(Cl)n2)C1,,CCO,,,,val
US04115575,CC(C)N1CC(CO)OC1c1ccccc1.NCCc1cnc(Cl)c(Cl)c1>>CC(C)NCC(O)COc1ncc(CCN)cc1Cl,,COCCOC,,[H-].[Na+],,val
US20130252936A1,CCOC(=O)CNN.N#CCC(=O)c1ccc(F)cc1>>CCOC(=O)Cn1nc(-c2ccc(F)cc2)cc1N,,CCO,,Cl,,val
US08067448B2,Cc1c(N[C@@H](C(=O)O)[C@@H](C)O)ccc(C#N)c1Cl.NNC(=O)c1ccccc1>>Cc1c(N[C@@H](C(=O)NNC(=O)c2ccccc2)[C@@H](C)O)ccc(C#N)c1Cl,,C1CCOC1,,ClCCCl,On1nnc2ccccc21,val
US20140194469A1,COC(=O)c1ccc2cnn(C(=O)OC(C)(C)C)c2c1>>CC(C)(C)OC(=O)n1ncc2ccc(CO)cc21,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20080027112A1,COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCC#N.C[Si](C)(C)N=[N+]=[N-]>>COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCc1nn[nH]n1,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US20130102776A1,C1COCCN1.C=O.O=C1COc2cc(O)ccc21>>O=C1COc2c1ccc(O)c2CN1CCOCC1,,CCO,,,,val
US20070232583A1,CC(C)(C)NS(=O)(=O)c1cccc(-c2cn(-c3nc(-c4ccc(F)cc4)cc(C(F)(F)F)n3)cn2)c1>>NS(=O)(=O)c1cccc(-c2cn(-c3nc(-c4ccc(F)cc4)cc(C(F)(F)F)n3)cn2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04552866,CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)OCC[Si](C)(C)C>>CC(C)C[C@H](N)C(=O)OCC[Si](C)(C)C,[Pd],CCOC(C)=O,,[H][H],,val
US20130217666A1,CCOC(=O)c1nc2c([nH]1)C1CC(C1)c1ccc(I)cc1-2.Cn1nc(CCl)c2ccccc21>>CCOC(=O)c1nc2c(n1Cc1nn(C)c3ccccc13)C1CC(C1)c1ccc(I)cc1-2,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US06423689B1,CC(C)(C)OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21.OCc1ccccn1>>CC(C)(C)OC(=O)[C@H](Cc1ccc(OCc2ccccn2)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20110178070A1,CC(=O)Nc1nc2ccc(Br)nc2s1.CC1(C)OB(c2ccc3[nH]ccc3c2)OC1(C)C>>CC(=O)Nc1nc2ccc(-c3ccc4[nH]ccc4c3)nc2s1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20160095858A1,CC(C)COc1cc(F)cc(-c2ccc(C(=O)NS(=O)(=O)c3cccc(N)n3)c(Cl)n2)c1.Cc1cc(I)cc(C)c1O>>Cc1cc(I)cc(C)c1Oc1nc(-c2cc(F)cc(OCC(C)C)c2)ccc1C(=O)NS(=O)(=O)c1cccc(N)n1,,CN1CCCC1=O,,[H-].[Na+],,val
US20030036655A1,Nc1ccc(Cc2ccc(N)cc2)cc1.O=C(Cl)OCc1ccccc1>>Nc1ccc(Cc2ccc(NC(=O)OCc3ccccc3)cc2)cc1,,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20140315879A1,CC(=O)OO.CC(C)Oc1ncc(B2OC(C)(C)C(C)(C)O2)cc1Cl>>CC(C)Oc1ncc(O)cc1Cl,,CC(=O)O,,O,,val
US20060004012A1,CC(=O)C(C)=NO.O=Cc1ccc(C(F)(F)F)cc1>>Cc1oc(-c2ccc(C(F)(F)F)cc2)[n+]([O-])c1C,,CC(=O)O,CCOCC,C1COCCO1,Cl,val
US20110315965A1,Brc1ccc2cc(Br)ccc2c1.OB(O)c1cc2ccccc2c2ccccc12>>Brc1ccc2cc(-c3cc4ccccc4c4ccccc34)ccc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20100125091A1,CC(=O)CC(=O)O[C@H](C)c1ccccc1.Nc1ccc(Cl)cc1C(=O)c1ccccc1>>Cc1nc2ccc(Cl)cc2c(-c2ccccc2)c1C(=O)O[C@H](C)c1ccccc1,,CCO,CCOCC,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US05447943,CC1(C)Oc2ccc(Br)cc2C(n2ccccc2=O)=C1CNO.C[Si](C)(C)N=C=O>>CC1(C)Oc2ccc(Br)cc2C(n2ccccc2=O)=C1CN(O)C(N)=O,,C1CCOC1,,ClCCl,O,val
US20100016279A1,FC(F)(F)c1nnc2ccc(N3CCC(Oc4ccc(OCc5ccccc5)cc4)CC3)nn12>>Oc1ccc(OC2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1,[Pd],CO,,,,val
US06025323,CC[C@H]1CC(C)(C)CC[C@@H]1O>>CC[C@H]1CC(C)(C)CCC1=O,,CC(C)=O,,O=S(=O)(O)O,O=[Cr](=O)=O,val
US20070060589A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)NCc1cccc(-n2nc(C(F)(F)F)cc2NC(=O)OCc2ccccc2)c1>>C[C@H](NC(=O)OC(C)(C)C)C(=O)NCc1cccc(-n2nc(C(F)(F)F)cc2N)c1,[Pd],CO,,[H][H],,val
US20070299258A1,CCN=C=S.OCCC1CCNCC1>>CCNC(=S)N1CCC(CCO)CC1,,ClCCl,,,,val
US20130158003A1,BrCCCCBr.O=Cc1nc(-c2ccccc2)c[nH]1>>O=Cc1nc(-c2ccccc2)cn1CCCCBr,,CN(C)C=O,,[I-].[K+],,val
US20100160288A1,Cc1nc(Cl)c(N)c(NC2CCOCC2)n1.O=C(Cl)c1ccccc1Cl>>Cc1nc(Cl)c(NC(=O)c2ccccc2Cl)c(NC2CCOCC2)n1,,CC(=O)N(C)C,,,,val
US20060052445A1,O=Cc1ccc(Sc2ccccc2Br)cc1>>OCc1ccc(Sc2ccccc2Br)cc1,,CCO,,[BH4-].[Na+],,val
US20090149456A1,COc1ccc2c(-c3ccnc(Nc4cccc(OCCN(C)C)c4)n3)c(-c3cccc(N)c3)nn2c1.O=C(O)C1(c2ccccc2)CC1>>COc1ccc2c(-c3ccnc(Nc4cccc(OCCN(C)C)c4)n3)c(-c3cccc(NC(=O)C4(c5ccccc5)CC4)c3)nn2c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06437165B1,CCCCCCCCc1ccc(CCC(C)(CCP(=O)(OCC)OCC)NC(=O)OCc2ccccc2)cc1>>CCCCCCCCc1ccc(CCC(C)(N)CCP(=O)(O)O)cc1,,ClCCl,,CO,,val
US20100197924A1,CC(C)(C)OC(=O)c1cc([C@@H](CO[Si](C)(C)C(C)(C)C)N=[N+]=[N-])cc(C(F)(F)F)c1>>CC(C)(C)OC(=O)c1cc([C@H](N)CO[Si](C)(C)C(C)(C)C)cc(C(F)(F)F)c1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05057534,COC(=O)CCC(=O)c1ccc(C)cc1.O=S(=O)(Cl)Cl>>COC(=O)CC(Cl)C(=O)c1ccc(C)cc1,,CO,ClCCl,[Na+].[OH-],,val
US06936602B1,CCOCCN(CCCC(=O)OC(C)(C)C)C(=O)OCc1ccccc1>>CCOCCNCCCC(=O)OC(C)(C)C,[Pd],CO,,,,val
US20060270656A1,Nc1ccccc1Sc1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C=Nc1ccccc1Sc1ccccc1,,C1COCCO1,,,,val
US05208248,CCOC(=O)c1ccc(NC=O)c(C(=O)CCNC(=O)OC(C)(C)C)c1.NO>>CCOC(=O)c1ccc(N)c(C(CCNC(=O)OC(C)(C)C)=NO)c1,,c1ccncc1,,Cl,,val
US20140011758A1,C[Si](C)(C)CCO.O=C(O)C1CC(F)(c2ccc(C3=NOC(c4cc(Cl)c(Cl)c(Cl)c4)(C(F)(F)F)C3)cc2)C1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>C[Si](C)(C)CCOC(=O)NC1CC(F)(c2ccc(C3=NOC(c4cc(Cl)c(Cl)c(Cl)c4)(C(F)(F)F)C3)cc2)C1,,C1CCOC1,,CCN(CC)CC,,val
US20110034521A1,O=C(CSC(c1ccccc1)(c1ccccc1)c1ccccc1)Nc1ccc(F)cn1>>O=C(CS)Nc1ccc(F)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130267526A1,CC(N)c1cc2cnccc2nc1-c1cccc(F)c1.Clc1ncnc2nc[nH]c12>>Fc1cccc(-c2nc3ccncc3cc2CNc2ncnc3[nH]cnc23)c1,,CCCCO,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20070060626A1,CCCCc1nc(-c2ccc(C(F)(F)F)cc2)sc1CO.CS(=O)(=O)Cl>>CCCCc1nc(-c2ccc(C(F)(F)F)cc2)sc1CCl,,ClCCl,,CCN(CC)CC,,val
US20060148854A1,N#Cc1cccc(B(O)O)c1.Nc1ncc(Br)cc1C=O>>N#Cc1cccc(-c2cnc(N)c(C=O)c2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US04714492,CO.COC(OC)OC.O=C(c1ccccc1)c1c(O)cc(-c2ccccc2)oc1=O>>COC1=C(c2ccccc2)OC(c2ccccc2)C(=C=O)C1=O,,O,,O=S(=O)(O)O,,val
US06391891B1,CN1CC=C(c2csc3ccc([N+](=O)[O-])cc23)CC1>>CN1CC=C(c2csc3ccc(N)cc23)CC1,,CCO,Cl,Cl[Sn]Cl,,val
US20090221555A1,COCCN1CCc2cc(OC)c([N+](=O)[O-])cc2CC1>>COCCN1CCc2cc(N)c(OC)cc2CC1,[Pd],CO,,NN,O,val
US20130005707A1,O=[N+]([O-])c1ccc(-c2ncn(C3CCCCO3)n2)cc1>>Nc1ccc(-c2ncn(C3CCCCO3)n2)cc1,[Pd],CO,,[H][H],,val
US20020103229A1,NN.O=C(c1ccccc1)c1ccccc1F>>c1ccc(-c2n[nH]c3ccccc23)cc1,,O,,,,val
US20150366197A1,COc1cc(OCc2ccccc2)ccc1C(O)c1c(-n2cccc2CO[Si](C)(C)C(C)(C)C)ccn1S(=O)(=O)c1ccc(C)cc1>>COc1cc(OCc2ccccc2)ccc1C(=O)c1c(-n2cccc2CO[Si](C)(C)C(C)(C)C)ccn1S(=O)(=O)c1ccc(C)cc1,,CS(C)=O,,,,val
US20030069434A1,CNCCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)C(=O)CC[C@H]3[C@H]12.Cc1ccc(S(=O)(=O)[O-])c(CCCCCCCCC(F)(F)C(F)(F)F)c1>>CN(CCCCCCCCC(F)(F)C(F)(F)F)CCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)C(=O)CC[C@H]3[C@H]12,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20050148627A1,C#C[Sn](CCCC)(CCCC)CCCC.CCOC(=O)C1=Cc2cc(Cl)c(Oc3ccc(I)cc3C)cc2OC1C(F)(F)F>>C#Cc1ccc(Oc2cc3c(cc2Cl)C=C(C(=O)OCC)C(C(F)(F)F)O3)c(C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20140187545A1,N#CC(C#N)Cc1cccc2ccccc12.NN>>Nc1n[nH]c(N)c1Cc1cccc2ccccc12,,CCO,,O,,val
US08492414B2,COc1ccc(-c2nsc(CBr)n2)cc1.NC(=O)c1c(F)ccc(O)c1F>>COc1ccc(-c2nsc(COc3ccc(F)c(C(N)=O)c3F)n2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090227786A1,O=C1[C@H](CCC2(c3ccc(F)cc3)OCCO2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1>>O=C(CC[C@H]1C(=O)N(c2ccc(F)cc2)[C@@H]1c1ccc(O)cc1)c1ccc(F)cc1,,CC(C)=O,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20040037022A1,CCN=C=O.Nc1ccc(C[C@@H](CO)N(Cc2ccccc2)C[C@H](O)COc2ccccc2)cc1>>CCNC(=O)Nc1ccc(C[C@@H](CO)N(Cc2ccccc2)C[C@H](O)COc2ccccc2)cc1,,ClCCl,,,,val
US20120295884A1,COc1ccc2c(c1)c(C(N)=O)cn2CC(=O)OC(C)(C)C>>COc1ccc2c(c1)c(C(N)=O)cn2CC(=O)O,,ClCCl,,CO,O=C(O)C(F)(F)F,val
US20120053173A1,COC(=O)c1ccc(NC(CC(C)C)c2oc3ccccc3c2C)cc1>>Cc1c(C(CC(C)C)Nc2ccc(C(=O)O)cc2)oc2ccccc12,,CCO,,C1CCOC1,[Na+].[OH-],val
US20060111375A1,C1CCNCC1.COc1cc2c(Oc3cc4ccccc4nc3C)ccnc2cc1OCCCCl>>COc1cc2c(Oc3cc4ccccc4nc3C)ccnc2cc1OCCCN1CCCCC1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150322002A1,COC(=O)c1ccc(Oc2ccc(OC(F)(F)F)c(Cl)c2)c(Br)c1.COc1ncccc1B(O)O>>COC(=O)c1ccc(Oc2ccc(OC(F)(F)F)c(Cl)c2)c(-c2cccnc2OC)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20050261291A1,CCC=O.Cc1ccc(N2CCNCC2)c(C2CC(C)(C)CC(C)(C)C2)c1>>CCCN1CCN(c2ccc(C)cc2C2CC(C)(C)CC(C)(C)C2)CC1,,C1CCOC1,CCOC(C)=O,O=C([O-])O.[Na+],,val
US20080318968A1,COC(=O)c1cc(Oc2cnc(C(=O)N(C)C)cn2)cc(O[C@@H](C)CO)c1.O=C(O)C(F)(F)S(=O)(=O)F>>COC(=O)c1cc(Oc2cnc(C(=O)N(C)C)cn2)cc(O[C@@H](C)COC(F)F)c1,[Cu]I,CC#N,,,,val
US20060205718A1,CCOc1cc(CO)cc(OCC)c1OC>>CCOc1cc(C=O)cc(OCC)c1OC,O=[Mn]=O,C1CCOC1,,,,val
US20080269244A1,CC(C)(C)OC(=O)N1CCNCC1.Cc1nc(Cl)ccc1[N+](=O)[O-]>>Cc1nc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1[N+](=O)[O-],,CCCCO,,CCN(CC)CC,O,val
US20110015157A1,C=CC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(-c3ccc(F)cc3F)cc2)C(=O)O1.O=C(OO)c1cccc(Cl)c1>>C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CC2CO2)(c2ccc(F)cc2)OC1=O,,ClCCl,,,,val
US04999378,COC(=O)c1ccc(OCC(C)CNc2ccc(Cl)cc2)cc1>>CC(CNc1ccc(Cl)cc1)COc1ccc(C(=O)O)cc1,,CO,O,Cl,[Na+].[OH-],val
US20060063787A1,CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc(C=O)c1C#N.CCOC(=O)CP(=O)(OCC)OCC>>CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc(C=CC(=O)OCC)c1C#N,,C1CCOC1,CCOC(C)=O,[Na+].[OH-],,val
US20160152609A1,COc1cc2c(cc1OC)-n1c(Br)nc(C(=O)N(C)C(C)(C)C)c1CC2.OB(O)c1ccsc1>>COc1cc2c(cc1OC)-n1c(-c3ccsc3)nc(C(=O)N(C)C(C)(C)C)c1CC2,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20110245264A1,CC[C@H](C)COc1ccc([C@H](CN2C(=O)c3ccccc3C2=O)NC(=O)OC(C)(C)C)cc1.O=C(Cl)C1CC1c1cccs1>>CC[C@H](C)COc1ccc([C@H](CN2C(=O)c3ccccc3C2=O)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US05206257,N#C/C(N)=C(/N)C#N.O=Cc1c(Cl)cc(C(F)(F)F)cc1Cl>>N#CC(N)=C(C#N)N=Cc1c(Cl)cc(C(F)(F)F)cc1Cl,,CO,,,,val
US20150087639A1,COC(=O)/C=C(/C)NC(C)=O.Nc1ccc(N2CCCC2)c(F)c1>>Cc1cc(=O)n(-c2ccc(N3CCCC3)c(F)c2)c(C)n1,,ClCCl,,C[Al](C)C,,val
US20160272592A1,NO.O=Cc1ccncc1Br>>ON=Cc1ccncc1Br,,O,,Cl,CC(=O)[O-].[Na+],val
US05994378,CC(C)(C)c1csc(-c2cc3cc(Cn4nc(C(N)=O)c5cc(OCc6ccccc6)ccc54)ccc3o2)n1>>CC(C)(C)c1csc(-c2cc3cc(Cn4nc(C(N)=O)c5cc(O)ccc54)ccc3o2)n1,,ClCCl,,,,val
US20130231333A1,CC/C(=C(/c1ccc(/C=C/C#N)cc1)c1ccc2c(cnn2C2CCCCO2)c1)c1ccccc1.C[Si](C)(C)N=[N+]=[N-]>>CC/C(=C(/c1ccc(/C=C/c2nn[nH]n2)cc1)c1ccc2c(cnn2C2CCCCO2)c1)c1ccccc1,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US20090075989A1,N#Cc1ccc(N)cc1Cl.O=C(O)C(=O)c1ccccc1>>N#Cc1ccc(NC(=O)C(=O)c2ccccc2)cc1Cl,,CC(=O)N(C)C,,O=S(Cl)Cl,,val
US20080021032A1,CSc1ccc([C@@H](C[C@H]2CCC3(C2)OCC(C)(C)CO3)C(=O)N(C)[C@H](C)[C@H](O)c2ccccc2)cc1C.O=S(=O)(O)O>>CSc1ccc([C@@H](C[C@H]2CCC(=O)C2)C(=O)O)cc1C,,C1COCCO1,O,,,val
US20050070539A1,CI.O=C(O)c1cc(S(=O)O)ccc1Cl>>CS(=O)(=O)c1ccc(Cl)c(C(=O)O)c1,,CO,O,[Na+].[OH-],,val
US20100093788A1,CCOC(=O)C1=NOC2(CCCCC2)C1>>O=C(O)C1=NOC2(CCCCC2)C1,,O,,CO,[Li+].[OH-],val
US20060276515A1,NC/C=C(\c1ccncc1)c1ccc(F)cc1>>NCCC(c1ccncc1)c1ccc(F)cc1,[Pd],CCO,,,,val
US20090203750A1,CC(C)(C)OC(=O)NC[C@@H]1C[C@H]1c1ccccc1N.O=C(Cl)c1ccccc1>>CC(C)(C)OC(=O)NC[C@@H]1C[C@H]1c1ccccc1NC(=O)c1ccccc1,CN(C)c1ccncc1,ClCCl,,,,val
US20050176772A1,COC(=O)/C=C/c1ccc(F)cc1F.COCN(Cc1ccccc1)[Si](C)(C)C.ClCCl>>COC(=O)[C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccc(F)cc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140219917A1,C#CCBr.OCCOCCOCCO>>C#CCOCCOCCOCCO,,C1CCOC1,O,Cl,[H-].[Na+],val
US05985281,BrC(Br)(Br)Br.O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2OCc2ccccc2)c(=O)[nH]1>>O=c1ccn([C@@H]2O[C@H](CBr)[C@@H](O)[C@H]2OCc2ccccc2)c(=O)[nH]1,,CN(C)C=O,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020193596A1,COC(=O)C(N)(CCS(C)(=O)=O)C(=O)c1ccc(NC(=O)c2cccnc2)cc1-c1ccccc1>>CS(=O)(=O)CCC(N)(C(=O)O)C(=O)c1ccc(NC(=O)c2cccnc2)cc1-c1ccccc1,,C1CCOC1,O,,,val
US20090291079A1,CC1(C)OB(c2ccc(N)cc2)OC1(C)C.Clc1nc(N2C3COCC2COC3)nc(N2C3COCC2COC3)n1>>Nc1ccc(-c2nc(N3C4COCC3COC4)nc(N3C4COCC3COC4)n2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20100311750A1,CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(Br)cn2)CN1C(=O)OC(C)(C)C.CN1CCNC1=O>>CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(N3CCN(C)C3=O)cn2)CN1C(=O)OC(C)(C)C,[Cu]I,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US05025031,OCCCl.Oc1ccc(-n2ccnc2)cc1>>OCCOc1ccc(-n2ccnc2)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090270414A1,CCOC(=O)Cn1c2c(c3cccc(Cl)c31)CC(C(=O)OCc1ccccc1)CC2>>CCOC(=O)Cn1c2c(c3cccc(Cl)c31)CC(C(=O)O)CC2,[Pd],CCO,,,,val
US20090048269A1,Cc1ccc(OCc2ccccc2)c(N2CCCC2)n1>>Cc1ccc(O)c(N2CCCC2)n1,[Pd],CCO,,,,val
US20130116216A1,C=CC(=O)Nc1ccc(S(=O)(=O)N2CCNCC2)cc1.O=C(Cl)Cl.OCc1ccccc1Cl>>C=CC(=O)Nc1ccc(S(=O)(=O)N2CCN(C(=O)OCc3ccccc3Cl)CC2)cc1,,C1CCOC1,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US05753665,CC(=O)C(C)Oc1ccc(Cl)cc1Cl.COC(OC)N(C)C>>CC(Oc1ccc(Cl)cc1Cl)C(=O)C=CN(C)C,,CO,,,,val
US05200409,N#CC(C#N)=C(S[Na])S[Na].O=[N+]([O-])c1ccc2nc(Cl)c(Cl)nc2c1>>N#CC(C#N)=C1Sc2nc3ccc([N+](=O)[O-])cc3nc2S1,,CN(C)C=O,,O,,val
US04579585,C=C(CCl)c1ccc([N+](=O)[O-])cc1.[F-]>>C=C(CF)c1ccc([N+](=O)[O-])cc1,,O,,[Br-].[K+],,val
US04497821,Cc1nc(C)c(C(=O)OC(C)C)c(-c2cccc([N+](=O)[O-])c2)c1C(=O)OC(C)C>>Cc1nc(C)c(C(=O)OC(C)C)c(-c2cccc([N+](=O)[O-])c2)c1C(=O)O,,CCO,O,[K+].[OH-],,val
US05665777,CC(C)(C)OC(=O)CBr.CCOC(=O)CCCOc1ccc(-c2ccc(C#N)cc2)cc1>>CCOC(=O)C(CCOc1ccc(-c2ccc(C#N)cc2)cc1)CC(=O)OC(C)(C)C,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US06399629B1,COC(=O)[C@H]1C[C@H](N=[N+]=[N-])CN1C(=O)OC(C)(C)C>>COC(=O)[C@H]1C[C@H](N)CN1C(=O)OC(C)(C)C,[Pd],CO,,,,val
US20090186886A1,C1CCNC1.O=CCCc1nc2cc3c(cc2[n+]([O-])n1)CCC3>>[O-][n+]1nc(CCCN2CCCC2)nc2cc3c(cc21)CCC3,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US05741715,C=C[C@H]1CN2CCC1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12>>C=CC1CN2CCC1CC2[C@H](O)c1ccnc2ccc(O)cc12,,ClCCl,,[Na+].[OH-],,val
US20090227570A1,CN(C)C(=O)CCl.O=C(Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1)NC1CCNCC1>>CN(C)C(=O)CN1CCC(NC(=O)Nc2ccc3nc(N[C@@H]4CCc5ccccc54)ccc3c2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20130029962A1,CC(C)(C)[Si](C)(C)OCCc1ccc(NC(=O)NCc2cc(C(F)(F)F)nn2-c2cccc(Cl)c2)cn1>>O=C(NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1)Nc1ccc(CCO)nc1,,C1CCOC1,,Cl,,val
US05559230,CS(=O)(=O)Cl.Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(CO)c3ccccc32)cc1>>Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(COS(C)(=O)=O)c3ccccc32)cc1,,CC#N,ClCCl,c1ccncc1,,val
US06624171B1,NS(=O)(=O)c1ccc(NC=C2C(=O)Nc3ccncc32)cc1>>NS(=O)(=O)c1ccc(NC=C2C(=O)Nc3ncccc32)cc1,,O,,,,val
US20150152131A1,Nc1ccn([C@H]2C[C@H](OC(=O)c3ccccc3)[C@@H](COC(=O)c3ccccc3)S2)c(=O)n1>>Nc1ccn([C@H]2C[C@H](O)[C@@H](CO)S2)c(=O)n1,,CO,,N,,val
US20150232465A1,CC(=O)N1c2ccc(Br)cc2NC[C@@H]1C.CC(C)OC(=O)Cl>>CC(=O)N1c2ccc(Br)cc2N(C(=O)OC(C)C)C[C@@H]1C,,ClCCCl,,CCN(C(C)C)C(C)C,,val
US20060040984A1,O=C(C1CC(O)C(O)C1)N1CCC(Oc2ccc(Cl)c(Cl)c2)CC1>>OC1CC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1O,,CO,,B,,val
US20130102776A1,CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2OCC3=O)CC1.O=Cc1c[nH]c2nc(-c3ccccc3)ccc12>>CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2O/C(=C\c2c[nH]c4nc(-c5ccccc5)ccc24)C3=O)CC1,C1CCNCC1,CO,,,,val
US20130261123A1,COc1ccc2cc(Cl)ncc2c1.O=C(O)c1ccc(B(O)O)cc1>>COc1ccc2cc(-c3ccc(C(=O)O)cc3)ncc2c1,,O,,,,val
US20080146612A1,CC1(CN)CCCCCC1.COC(=O)c1ccccc1-c1ccc(Cl)c(C(=O)[O-])c1>>COC(=O)c1ccccc1-c1ccc(Cl)c(C(=O)NCC2(C)CCCCCC2)c1,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20020049222A1,C=C1CCC(CC(C)C)(C(=O)OC)C1>>C=C1CCC(CC(C)C)(C(=O)O)C1,,C1COCCO1,O,[Li+].[OH-],,val
US20140309213A1,Cc1c([C@@H](O)CN2[C@H]3CC[C@@H]2CNC3)ccc2c1COC2=O.O=C(CBr)c1ccc2c(c1)C=CS2(=O)=O>>Cc1c([C@@H](O)CN2CCN(CC(=O)c3ccc4c(c3)C=CS4(=O)=O)CC2)ccc2c1COC2=O,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20120202787A1,COc1cc(C#N)ncc1Br.COc1cc(C(N)=O)ncc1Br.O=C(Cl)C(=O)Cl.c1ccncc1>>COc1cc(C(=O)O)ncc1-n1cnc(C)c1,,CN(C)C=O,,,,val
US20150005289A1,COc1ccc(-c2cc(=O)n3cc(N4CCC5(CC4)OCCO5)cc(C)c3n2)cc1OC>>COc1ccc(-c2cc(=O)n3cc(N4CCC(=O)CC4)cc(C)c3n2)cc1OC,,C1COCCO1,ClCCl,Cl,O=C([O-])[O-].[K+].[K+],val
US05726197,O=C1NC(=O)c2cc(Cl)ccc21>>Clc1cccc2c1CNC2,,C1CCOC1,,Cl,,val
US20120202834A1,CC(C)C[Mg]Br.COC(=O)c1ccc(C=Nc2cnc(-n3cc(C(F)(F)F)cn3)c(C)c2)nc1>>COC(=O)c1ccc(C(CC(C)C)Nc2cnc(-n3cc(C(F)(F)F)cn3)c(C)c2)nc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20080227104A1,CI.c1ccc2ncccc2c1>>C[n+]1cccc2ccccc21.[I-],,C1COCCO1,,,,val
US20160009704A1,CS(=O)(=O)Cl.NCc1cn(CCCCn2cc(C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)nn1>>CS(=O)(=O)NCc1cn(CCCCn2cc(C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)nn1,,ClCCl,,,,val
US20090069288A1,CC(C)(C)[Si](C)(C)OCc1ccc(NC(=O)c2cc(-c3ccccc3)no2)cc1>>O=C(Nc1ccc(CO)cc1)c1cc(-c2ccccc2)no1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130217666A1,CCOC(=O)c1nc2c(s1)C(O)COc1ccc(Br)cc1-2.CI>>CCOC(=O)c1nc2c(s1)C(OC)COc1ccc(Br)cc1-2,,ClCCl,,,,val
US20030040513A1,CCN(C(C)C)C(C)C.CN(C)C=O.CN1CCCC1=O.O=C(O)c1cnc(N2CCC(N3C(=O)OCc4ccccc43)CC2)c(Cl)c1>>N#CC(NC(=O)c1cnc(N2CCC(N3C(=O)OCc4ccccc43)CC2)c(Cl)c1)C(N)=O,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20140275152A1,CN1CCC(CCl)=C(c2ccccc2)C1.O=Cc1c(O)cccc1O>>CN1CCC(COc2cccc(O)c2C=O)=C(c2ccccc2)C1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20030199550A1,C=CCNC.CN(C[C@@H]1CC[C@@H](CCCCCBr)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1>>C=CCN(C)CCCCC[C@@H]1CC[C@@H](CN(C)S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1,,CO,,,,val
US20120115902A1,COC(=O)c1cc([N+](=O)[O-])c(N)nc1OCC(F)F>>COC(=O)c1cc(N)c(N)nc1OCC(F)F,[Ni],C1CCOC1,CO,,,val
US20040122016A1,C1CNCCN1.O=C(Cc1cccc(OCCCCl)c1)Nc1nc(-c2ccncc2)cs1>>O=C(Cc1cccc(OCCCN2CCNCC2)c1)Nc1nc(-c2ccncc2)cs1,,O,,CS(C)=O,,val
US20100048639A1,NC(=O)c1ccc(C2=CCCCC2)c(C(F)(F)F)c1.O>>O=C(O)c1ccc(C2=CCCCC2)c(C(F)(F)F)c1,,CCO,,[K+].[OH-],,val
US20160046597A1,Cc1c([N+](=O)[O-])ccc2c1c(C1=CCN(C(=O)OC(C)(C)C)CC1)cn2C.Cl>>Cc1c([N+](=O)[O-])ccc2c1c(C1=CCNCC1)cn2C.Cl,,C1COCCO1,,,,val
US05434169,CCOC(C)=O.CN(C)C=O.Cc1[nH]cnc1C1CCNCC1.ClCCl.O=C(O)c1n[nH]c2ccccc12.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cc1[nH]cnc1C1CCN(C(=O)c2n[nH]c3ccccc23)CC1.O=C(O)/C=C/C(=O)O,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20130172312A1,CCOc1ccc(OC2CN(c3ccc([C@H](C)N)cc3)C2)cc1.Cc1cc(C(=O)Cl)c(C)o1>>CCOc1ccc(OC2CN(c3ccc([C@H](C)NC(=O)c4cc(C)oc4C)cc3)C2)cc1,,ClCCl,,,,val
US20090137557A1,NCCc1cccc(F)c1.O=c1oc(-c2cccs2)nc2c1CCCC2>>O=c1c2c(nc(-c3cccs3)n1CCc1cccc(F)c1)CCCC2,,CC(=O)O,,,,val
US20160264551A1,CC(C)(C)OC(=O)Nc1ccc(C(=O)N2CCCC(Nc3ncc(Cl)c(-c4cn(S(=O)(=O)c5ccccc5)c5ccccc45)n3)C2)cc1>>Nc1ccc(C(=O)N2CCCC(Nc3ncc(Cl)c(-c4cn(S(=O)(=O)c5ccccc5)c5ccccc45)n3)C2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090274648A1,CC(C)(C)OC(=O)NC1(C(=O)O)CC1C(F)F.NS(=O)(=O)C1CC1>>CC(C)(C)OC(=O)NC1(C(=O)NS(=O)(=O)C2CC2)CC1C(F)F,,C1CCOC1,,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US06300353B1,BrC(Br)(Br)Br.Cc1cc(CO)cc(C)c1OC(=O)CNCC(=O)OC(C)(C)C>>Cc1cc(CBr)cc(C)c1OC(=O)CNCC(=O)OC(C)(C)C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05169428,NC(=O)c1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1Cl>>N#Cc1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1Cl,,O=S(Cl)Cl,,,,val
US20090239845A1,Cc1cc(NC(=O)c2ccccc2CO)nn1Cc1cc(Cl)ccc1OCC(C)C>>Cc1cc(N2C(=O)c3ccccc3C2=O)nn1Cc1cc(Cl)ccc1OCC(C)C,,CCOC(C)=O,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20050130943A1,COC(=O)c1c(C(C)=O)cc(F)c(F)c1Nc1ccccc1Cl>>CC(=O)c1cc(F)c(F)c(Nc2ccccc2Cl)c1C(=O)O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20100234340A1,CC(C)(C)OC(=O)N1CCC2=CCC(C)(C(=O)[O-])C=C2C1>>CC(C)(C)OC(=O)N1CCc2ccc(C(=O)O)cc2C1,,CO,O,[Li+].[OH-],,val
US20080009491A1,C1COCCN1.O=C(Cl)c1nc(CCN2CCOCC2)n2ccccc12>>O=C(c1nc(CCN2CCOCC2)n2ccccc12)N1CCOCC1,,ClCCl,,CCN(CC)CC,Cl,val
US20090137580A1,Cn1ccc2ncnc(Cl)c21.Nc1ccc(O)c2ncccc12>>Cn1ccc2ncnc(Oc3ccc(N)c4cccnc34)c21,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US06008230,COCCN.O=C(Nc1cccc2c(Cl)ccnc12)c1c(Cl)cccc1Cl>>COCCNc1ccnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc12,,CN1CCCC1=O,,O,,val
US20020016368A1,COC(=O)c1ccc(C#CCNC(=O)OC(C)(C)C)o1>>COC(=O)c1ccc(CCCNC(=O)OC(C)(C)C)o1,[Pd],CO,,,,val
US20160068532A1,Cn1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc4[nH]c(=O)ccc4cc23)cn1.O=C(O)C(F)(F)F>>Cn1cc(-c2n[nH]c3cc4[nH]c(=O)ccc4cc23)cn1.O=C(O)C(F)(F)F,,ClCCl,,CC[SiH](CC)CC,,val
US20050054670A1,CC(C)(C)OC(=O)N1Cc2cc(N3Cc4cccc(NCc5ccc6ncccc6c5)c4C3=O)ccc2C(C)(C)C1>>CC1(C)CNCc2cc(N3Cc4cccc(NCc5ccc6ncccc6c5)c4C3=O)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110230457A1,C=O.CNC(=O)CN[C@@H]1CC[C@@H](CN(C)c2ccc(N3C(=O)Cc4cc(OC)c(OC(C)C)cc4[C@@H]3c3ccc(Cl)cc3)nc2)CC1>>COc1cc2c(cc1OC(C)C)[C@H](c1ccc(Cl)cc1)N(c1ccc(N(C)C[C@@H]3CC[C@@H](N4CC(=O)N(C)C4)CC3)cn1)C(=O)C2,,CCO,,,,val
US05925630,CC(C)O[C@H]1C[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]32)C[C@@H]1O.Cc1ccc(S(=O)(=O)NN)cc1>>Cc1ccc(S(=O)(=O)NN=C2CC[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](OC(C)C)C[C@]5(C)[C@H]4CC[C@]23C)cc1,,ClCCl,,CCO,,val
US20050282863A1,BrCCCCCBr.c1ccc2c(c1)CCCc1c-2[nH]c2ccccc12>>BrCCCCCn1c2c(c3ccccc31)CCCc1ccccc1-2,,CN(C)C=O,,O,[H-].[Na+],val
US20150087626A1,COC(=O)c1ccc(C2(NC(=O)C3CC4CC4CN3)CC2)cc1.FC(F)(F)c1ccc(CBr)cc1>>COC(=O)c1ccc(C2(NC(=O)C3CC4CC4CN3Cc3ccc(C(F)(F)F)cc3)CC2)cc1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150274696A1,O=C(Nc1ccn2nccc2c1)C(F)(F)F.O=C1CCC(=O)N1Cl>>O=C(Nc1ccn2ncc(Cl)c2c1)C(F)(F)F,,CC#N,,,,val
US20110311474A1,CC1CC(N)CC1c1cnc2cnc3[nH]ccc3n12.O=S(=O)(Cl)CCC(F)(F)F>>C[C@@H]1C[C@H](NS(=O)(=O)CCC(F)(F)F)C[C@@H]1c1cnc2cnc3[nH]ccc3n12,,CN(C)C=O,,,,val
US05889134,CCCCCCOc1cc(Br)c(OCCCCCC)cc1Br>>CCCCCCOc1ccc(OCCCCCC)c(Br)c1,,C1CCOC1,,[Li]CCCC,,val
US04431589,Cl.Cn1nc(C#N)c(Nc2cc(Cl)c(Cl)cc2[N+](=O)[O-])n1>>Cl.Cn1nc2c(n1)C(N)=Nc1cc(Cl)c(Cl)cc1N2,,CCO,Cl,,,val
US08501746B2,COc1ccn(-c2nc(C)c(C(=O)NCc3cccnc3)s2)c(=O)c1.O=C(OO)c1cccc(Cl)c1>>COc1ccn(-c2nc(C)c(C(=O)NCc3ccc[n+]([O-])c3)s2)c(=O)c1,,ClCCl,,,,val
US20020193614A1,CC(C)(C)OC(=O)N1CCC(Nc2ccc([N+](=O)[O-])cc2C(=O)NCc2ccc3c(c2)OCO3)CC1>>O=C(NCc1ccc2c(c1)OCO2)c1cc([N+](=O)[O-])ccc1NC1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090005421A1,CCC1(CC)CCc2c(csc2C(=O)O)C1.CI>>CCC1(CC)CCc2c(C(=O)O)sc(C)c2C1,,CC#N,,[Li]CCCC,,val
US05086178,ClC[N+]12CCN(CC1)CC2.O=S(=O)([O-])C(F)(F)F>>ClC[N+]12CCN(CC1)CC2.O=S(=O)([O-])C(F)(F)F,,CC#N,,[Cl-].[Li+],,val
US05426119,CCNCC.O=C(O)CCCC=C(c1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1)c1cccnc1>>CCN(CC)C(=O)CCCC=C(c1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1)c1cccnc1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20080119488A1,Cc1ccc(C#N)c(C)n1>>Cc1ccc(CN)c(C)n1,[Ni],CCO,,[NH4+].[OH-],,val
US20100152168A1,CCC=O.COc1ccc(S(=O)(=O)n2c(=O)n(C(C(=O)N3CCN(C4CCNCC4)CC3)c3ccccc3)c3cc(Cl)ccc32)cc1>>CCCN1CCC(N2CCN(C(=O)C(c3ccccc3)n3c(=O)n(S(=O)(=O)c4ccc(OC)cc4)c4ccc(Cl)cc43)CC2)CC1,,C1CCOC1,,,,val
US20080280911A1,CCCC[Sn](CCCC)(CCCC)SCC.NC(=O)c1nnc2c(F)cc(I)cc2c1Cl>>CCSc1cc(F)c2nnc(C(N)=O)c(Cl)c2c1,,CN(C)C=O,,,,val
US20020032327A1,CC(C)n1cnc2c(Cl)nc(Cl)nc21.Nc1ccccc1>>CC(C)n1cnc2c(Nc3ccccc3)nc(Cl)nc21,,CCCCO,CCOC(C)=O,,,val
US20070093515A1,CCNCC.COc1cc2ncnc(N3CCc4[nH]nc(CCl)c4C3)c2cc1OC>>CCN(CC)Cc1n[nH]c2c1CN(c1ncnc3cc(OC)c(OC)cc13)CC2,,C1CCOC1,,,,val
US20100125062A1,COC(=O)Cc1ccc(O)cc1.Nc1ccccc1N>>Oc1ccc(Cc2nc3ccccc3[nH]2)cc1,,CO,,,,val
US20040097524A1,CCOC(=O)CCc1nc(-c2ccco2)c2sccc2n1>>O=C(O)CCc1nc(-c2ccco2)c2sccc2n1,,C1CCOC1,O,[Li+].[OH-],,val
US20020042537A1,CC(C)(CCCI)[N+](=O)[O-].CCOC(=O)C(NC(C)=O)C(=O)OCC>>CCOC(=O)C(CCCC(C)(C)[N+](=O)[O-])(NC(C)=O)C(=O)OCC,,CCO,,C,C[O-].[Na+],val
US20060240048A1,CCOC(=O)c1ccc(O)nc1C(C)C.O=P(Cl)(Cl)Oc1ccccc1>>CCOC(=O)c1ccc(Cl)nc1C(C)C,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20160115149A1,Cc1sc(S(=O)(=O)Cl)cc1C(=O)Nc1ccc(F)c(F)c1.NC1(C(F)(F)F)CC1>>Cc1sc(S(=O)(=O)NC2(C(F)(F)F)CC2)cc1C(=O)Nc1ccc(F)c(F)c1,,c1ccncc1,,,,val
US20090099207A1,COC(=O)C1CS(=O)(=O)CC(Cc2ccc(OC)c(Br)c2)C1O>>COc1ccc(CC2CS(=O)(=O)CC(C(=O)O)C2O)cc1Br,,C1COCCO1,,Cl,[Na+].[OH-],val
US20050288273A1,CC(=O)NC[C@H]1CN(c2cc(F)c3c(c2)CCCCC3=O)C(=O)O1.Cc1cc(C(=O)Cl)no1>>CC(=O)NC[C@H]1CN(c2cc(F)c3c(c2)CCCC(C(=O)c2cc(C)on2)C3=O)C(=O)O1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20020193382A1,Clc1cc(N2CCC3(CC2)OCCO3)ncn1>>O=C1CCN(c2cc(Cl)ncn2)CC1,,CC(C)=O,,Cl,,val
US20040242629A1,O=C(Cl)N(Cc1ccccc1)c1ccccc1.OC12CCN(CC1)C2>>O=C(OC12CCN(CC1)C2)N(Cc1ccccc1)c1ccccc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US04061761,CC(=O)c1ccc(Cl)c(S(=O)(=O)Cl)c1.CNC>>CC(=O)c1ccc(Cl)c(S(=O)(=O)N(C)C)c1,,O,,CO,,val
US05122523,C=C(Cc1cccc2ccccc12)C(=O)OCC.OCCS>>CCOC(=O)C(CSCCO)Cc1cccc2ccccc12,,CCOCC,,CC(C)(C)[O-].[K+],,val
US20090186900A1,CC(=O)c1ccc(C(=O)O)cc1.CNc1ccc(OC)cc1>>COc1ccc(N(C)C(=O)c2ccc(C(C)=O)cc2)cc1,CN(C)c1ccncc1,CCN(CC)CC,ClCCl,CCN=C=NCCCN(C)C,,val
US05753676,CC(=O)Cl.COc1ccc(CC2Cc3cc(C)cnc3C(O)C2)cc1>>COc1ccc(C[C@H]2Cc3cc(C)cnc3[C@@H](OC(C)=O)C2)cc1,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060100229A1,CCNN.CCOC(=O)C(=O)CC(C)=O>>CCOC(=O)c1cc(C)n(CC)n1,,CCO,,O=C(O)C(=O)O,,val
US20120172291A1,CCOC(=O)[C@@]12C[C@H]1CC(F)(F)CCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@@H](O)C[C@H]1C(=O)N2.Oc1cnc2ccccc2n1>>CCOC(=O)[C@@]12C[C@H]1CC(F)(F)CCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Oc3cnc4ccccc4n3)C[C@H]1C(=O)N2,,C1CCOC1,ClCCl,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05580985,CCOC(=O)Cn1nc(-c2ccc(S(C)(=O)=O)cc2)c(-c2ccc(F)cc2)c1C(F)(F)F>>CS(=O)(=O)c1ccc(-c2nn(CC(=O)O)c(C(F)(F)F)c2-c2ccc(F)cc2)cc1,,C1CCOC1,,[Li+].[OH-],,val
US20050020541A1,C=C(c1ccc(OC)cc1)[Si]1(OC)CCCC1>>C=C(c1ccc(OC)cc1)[SiH]1CCCC1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090197871A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)O)c1.CN1CCC(Cc2cccc(-c3cccc(CN)c3)c2)CC1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2cccc(-c3cccc(CC4CCN(C)CC4)c3)c2)c1,,ClCCl,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20020173527A1,COc1ccc(Cn2cc(C)c3ccc(C(=O)N(C)OC)cc32)cc1.Cl[Mg]c1ccccc1>>COc1ccc(Cn2cc(C)c3ccc(C(=O)c4ccccc4)cc32)cc1,,C1CCOC1,,Cl,,val
US20100292212A1,O=[N+]([O-])c1ccc(F)cc1.OC1CCOC1>>O=[N+]([O-])c1ccc(OC2CCOC2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20110319394A1,CCI.Cc1ccnc2c1[nH]c(=O)n2-c1ccc(OCc2ccccc2)cc1>>CCn1c(=O)n(-c2ccc(OCc3ccccc3)cc2)c2nccc(C)c21,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080207621A1,Nc1ccc(S(N)(=O)=O)cc1.O=C=NC12CC3CC(CC(C3)C1)C2>>NS(=O)(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1,,CCO,,,,val
US04353823,N=C(N)NCCC[C@H](N)C(=O)O.O=C(O)[C@@H]1CCCN1C(=O)OCc1ccccc1>>N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1)C(=O)O,,C1COCCO1,O,,,val
US20090215743A1,CCOC(=O)CCCNC(=O)OC(C)(C)C.NN>>CC(C)(C)OC(=O)NCCCC(=O)NN,,CCO,,O,,val
US20060235030A1,CSc1nc(-c2cc(C(=O)O)ccc2C)c2c(n1)N(c1c(F)cccc1F)C(=O)NC2.Nc1nccs1>>CSc1nc(-c2cc(C(=O)Nc3nccs3)ccc2C)c2c(n1)N(c1c(F)cccc1F)C(=O)NC2,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100029687A1,COC(=O)c1ccc(C(=O)Cl)cc1.C[C@H](c1cccc2ccccc12)N(CC1CCNCC1c1ccccc1)C(=O)OC(C)(C)C>>COC(=O)c1ccc(C(=O)N2CCC(CN(C(=O)OC(C)(C)C)[C@H](C)c3cccc4ccccc34)C(c3ccccc3)C2)cc1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
USH0000918,CO.O=CC(O)CO.O=CCO.OCCO>>O=C[C@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,,CO,,,,val
US20050239751A1,O=C(CCNc1ccnc(-c2cc(-c3c(Cl)cccc3Cl)no2)c1)c1cccnc1.O=C(Cl)C(Cl)Cl>>O=C(CCN(C(=O)C(Cl)Cl)c1ccnc(-c2cc(-c3c(Cl)cccc3Cl)no2)c1)c1cccnc1,,ClCCl,,CCN(CC)CC,,val
US20050014749A1,Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CO)ccc32)cc1>>Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(C=O)ccc32)cc1,O=[Mn]=O,ClCCl,,,,val
US20080188452A1,O=C1CCCCc2c1cccc2[N+](=O)[O-]>>Nc1cccc2c1CCCCC2,[Pd],CC(=O)O,,[H][H],,val
US03997535,Nc1nnn[nH]1.O=C(O)c1nc2ccccc2nc1Cl>>O=C(Nc1nnn[nH]1)c1nc2ccccc2nc1Cl,,C1CCOC1,CN(C)C=O,,,val
US20110282066A1,CC(=O)Cl.CCOC(=O)c1cccc(Nc2ccc(C#N)cc2N)c1>>CCOC(=O)c1cccc(-n2c(C)nc3cc(C#N)ccc32)c1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20110021489A1,O=C(N1CCOCC1)N1CC(c2ccc(C(F)(F)F)cc2)CC(c2nc(Cl)no2)C1.O[C@H]1CCNC1>>O=C(N1CCOCC1)N1CC(c2ccc(C(F)(F)F)cc2)CC(c2nc(N3CC[C@H](O)C3)no2)C1,,CCO,,,,val
US20090118530A1,COC(=O)OC.Oc1ccccc1>>COC(=O)Oc1ccccc1,,CO,,,,val
US07618996B2,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1(C)OC(=O)c2ccc(Oc3ccc(CNCCC4CC4)cc3F)cc2O1>>CC(C)(C)OC(=O)N(CCC1CC1)Cc1ccc(Oc2ccc3c(c2)OC(C)(C)OC3=O)c(F)c1,,CCOC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090048251A1,Fc1cccc2ncnc(Cl)c12.Nc1ccc2[nH]ncc2c1>>Fc1cccc2ncnc(Nc3ccc4[nH]ncc4c3)c12,,CC(C)O,,,,val
US20150098914A1,CCCCCCCCCCCCCCO.O=C1O[C@@H]2[C@@H](O)[C@H](O)O[C@@H]2C1O>>CCCCCCCCCCCCCCO[C@H]1O[C@@H]2[C@H](O)C(=O)O[C@@H]2[C@H]1O,,C1CCOC1,,,,val
US20100093702A1,Cc1cc2c(N)nc(-c3ccc(C(C)(C)C)s3)nc2s1.O=[Se]=O>>CC(C)(C)c1ccc(-c2nc(N)c3cc(C=O)sc3n2)s1,,O,,C1COCCO1,,val
US20080132480A1,CCC(CC)NC(=O)c1ccc(-c2cc(Cl)ccc2O)cc1F.COC(=O)[C@@H](C)Oc1ccc(C)cc1>>CCC(CC)NC(=O)c1ccc(-c2cc(Cl)ccc2O[C@@H](C)C(=O)O)cc1F,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20120129836A1,Cc1ncc(C)n2nc(C=Cc3cn4c(n3)-c3ccccc3C4)nc12>>Cc1ncc(C)n2nc(CCc3cn4c(n3)-c3ccccc3C4)nc12,[Pd],CO,,,,val
US20010051631A1,CS(=O)(=O)OS(C)(=O)=O.Cc1nc2cccc3n(CCCN)c(=O)c1n23>>Cc1nc2cccc3n(CCCNS(C)(=O)=O)c(=O)c1n23,,ClCCl,,CCN(CC)CC,,val
US20060106048A1,CCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccccc1)=NC(C)(CN)C2.CS(=O)(=O)Cl>>CCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccccc1)=NC(C)(CNS(C)(=O)=O)C2,,C1CCOC1,,O,[Na+].[OH-],val
US20080161289A1,N.O=C(O)c1ccc(-c2nc3c(s2)CCN(C2CCC2)CC3)cc1>>NC(=O)c1ccc(-c2nc3c(s2)CCN(C2CCC2)CC3)cc1,,ClCCl,,,,val
US20100331368A1,CONC(=N)c1ccc(-c2ccc(-c3ccc(C(=N)NOC)cn3)[se]2)cc1>>N#Cc1ccc(-c2ccc[se]2)nc1,,CN(C)C=O,,,,val
US20020151715A1,CC(=O)O.CCOC(=O)C[N+](=O)[O-].CCOC(OCC)OCC.Nc1cccc(Br)c1>>O=C(O)c1cn(-c2cccc(Br)c2)cn1,[Fe],,,,,val
US04096263,CC(=O)OC(C)=O.CCOC(CNc1ccccn1)OCC>>CCOC(CN(C(C)=O)c1ccccn1)OCC,,c1ccncc1,,,,val
US20080045554A1,N#CCc1ccc(C(F)(F)F)cc1.NO>>N/C(Cc1ccc(C(F)(F)F)cc1)=N\O,,CO,,Cl,O=C([O-])O.[Na+],val
US20100273786A1,COC(=O)c1nc(C(F)(F)F)n2c1CN(C(=O)C[C@@H](Cc1cc(F)c(F)cc1F)NC(=O)OC(C)(C)C)CC2.Cl>>COC(=O)c1nc(C(F)(F)F)n2c1CN(C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)CC2.Cl,,CCOC(C)=O,,,,val
US20160176806A1,C=CNC(=O)c1ccccc1C(F)(F)F.O=Cc1ccc(F)cn1>>O=C(N[C@H]1CO[C@H]1c1ccc(F)cn1)c1ccccc1C(F)(F)F,,CC#N,,,,val
US20160002175A1,CNc1cc(Cl)nc(N)n1.Cc1c(C#N)cccc1B(O)O>>CNc1cc(-c2cccc(C#N)c2C)nc(N)n1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20090192163A1,CN(C)C(=S)Cl.O=C(O)Cc1cc(O)cc(C(F)(F)F)c1>>CN(C)C(=S)Oc1cc(CC(=O)O)cc(C(F)(F)F)c1,CN(C)c1ccncc1,C1COCCO1,O,CCN(CC)CC,,val
US20120010208A1,Cc1ccc(S(=O)(=O)n2ccc3c(-c4c(-c5ccc(F)cc5)nc5ccc(N6CCN[C@H](C)C6)nn45)ccnc32)cc1>>C[C@@H]1CN(c2ccc3nc(-c4ccc(F)cc4)c(-c4ccnc5[nH]ccc45)n3n2)CCN1,,CO,,O,[Na+].[OH-],val
US20090221555A1,C=C1CN=C(c2cccc(F)c2Nc2nc(Nc3ccc4c(c3)CCOC(=O)N4C)ncc2Cl)O1>>Cc1cnc(-c2cccc(F)c2Nc2nc(Nc3ccc4c(c3)CCOC(=O)N4C)ncc2Cl)o1,,CC#N,,C1COCCO1,Cl,val
US04684653,CCOC(=O)CC[C@H](NC(=O)c1ccc(C=Cc2cnc3nc(NC(C)=O)nc(O)c3c2)cc1)C(=O)OCC>>CCOC(=O)CC[C@H](NC(=O)c1ccc(CCc2cnc3nc(NC(C)=O)nc(O)c3c2)cc1)C(=O)OCC,[Pd],O=C(O)C(F)(F)F,,[H][H],,val
US20130137689A1,CCc1cc(OC)c(Oc2ccc(C(=O)N3CCNC(=O)C3)cc2F)cc1F.NC(=O)CBr>>CCc1cc(OC)c(Oc2ccc(C(=O)N3CCN(CC(N)=O)C(=O)C3)cc2F)cc1F,,C1CCOC1,O,CCOC(C)=O,[H-].[Na+],val
US20120202785A1,Cc1ccc(S(=O)(=O)n2c(C(C)N)c(-c3ccccc3)c3ccccc32)cc1.Clc1ncnc2[nH]cnc12>>Cc1ccc(S(=O)(=O)n2c(C(C)Nc3ncnc4[nH]cnc34)c(-c3ccccc3)c3ccccc32)cc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US04987138,COc1ccc(CN(C)C(=O)CC2c3cc(C#N)ccc3OC(C)(C)C2O)cc1>>CNC(=O)CC1c2cc(C#N)ccc2OC(C)(C)C1O,,O,,,,val
US20090012074A1,CCCN.COc1ccc2c(c1)OCC(=O)C2>>CCCNC1COc2cc(OC)ccc2C1,,ClCCl,O,CC(=O)O,[Na+].[OH-],val
US20060257543A1,CCOc1ccc(N)cc1.S=C=NCc1ccco1>>CCOc1ccc(NC(=S)NCc2ccco2)cc1,,CC#N,,,,val
US20160115126A1,C=CC(=O)Cl.CNC1CCCN(c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1>>C=CC(=O)N(C)C1CCCN(c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,,val
US05244890,C=CC1=NC=C(OCc2ccccc2)C(=O)C1.CNC>>CN(C)CCC1=NC=C(OCc2ccccc2)C(=O)C1,,CCO,,,,val
US20150166480A1,CCOC(=O)c1ccc(-c2ccc(OCC3CCN(CC(C)(C)F)CC3)c(CO)c2)cc1F>>CC(C)(F)CN1CCC(COc2ccc(-c3ccc(C(=O)O)c(F)c3)cc2CO)CC1,,C1CCOC1,O,[Li]O,,val
US05240938,C=CCc1cc(C(=O)OC)cc(CC=C)c1O[Si](C)(C)C(C)(C)C>>CCCc1cc(C(=O)OC)cc(CCC)c1O[Si](C)(C)C(C)(C)C,,CCO,,[H][H],,val
US05041455,CI.COCCOCCOc1nsnc1-c1cccnc1>>COCCOCCOc1nsnc1-c1ccc[n+](C)c1.[I-],,CC(C)=O,,,,val
US20100016287A1,CC(=O)CCO.FC(F)(F)c1nc2cc3c(c(Br)c2o1)CCNCC3>>CC(CCO)N1CCc2cc3nc(C(F)(F)F)oc3c(Br)c2CC1,,C1CCOC1,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120022060A1,O=C(Cl)c1cccc(Cl)c1.O=C(Nc1ccc(Nc2ccnc3[nH]c4c(c23)CNCC4)cc1)c1ccccc1>>O=C(Nc1ccc(Nc2ccnc3[nH]c4c(c23)CN(C(=O)c2cccc(Cl)c2)CC4)cc1)c1ccccc1,,ClCCCl,,CCN(CC)CC,,val
US20070254937A1,CC(=O)n1ncc2sc(Br)cc21>>Brc1cc2[nH]ncc2s1,,CCOC(C)=O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20060258722A1,COC(=O)c1ccc(CBr)cc1.c1ccc(CCNc2nc(-c3ccccc3)cs2)cc1>>COC(=O)c1ccc(CN(CCc2ccccc2)c2nc(-c3ccccc3)cs2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20080125431A1,O=C1OC2(CCC3(CC2)OCCO3)CN1Cc1ccc(-c2ccc(F)cc2)cc1>>O=C1CCC2(CC1)CN(Cc1ccc(-c3ccc(F)cc3)cc1)C(=O)O2,,C1CCOC1,,Cl,,val
US20120108627A1,CC(C)(C#N)c1ccc(-n2c(=O)[nH]c3cnc4ccc(Br)cc4c32)cc1.S=C=NCCCl>>CC(C)(C#N)c1ccc(-n2c(=O)n(C(=S)NCCCl)c3cnc4ccc(Br)cc4c32)cc1,,ClCCl,,CCN(CC)CC,O,val
US20100311790A1,C=CCCCBr.O=C(NCc1cccc(O)c1)c1ccc2ncccc2c1>>C=CCCCOc1cccc(CNC(=O)c2ccc3ncccc3c2)c1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US07939581B2,NCCOCc1ccc(C(=O)c2ccccc2)cc1.O=C=Nc1ccccc1>>O=C(NCCOCc1ccc(C(=O)c2ccccc2)cc1)Nc1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US06350749B1,Cc1ccnc2c1C(=O)CC(c1cccc(Cl)c1Cl)C2.Cl.N=C(NN)NO>>Cc1ccnc2c1C(=NNC(=N)NO)CC(c1cccc(Cl)c1Cl)C2.Cl,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20020082265A1,Cc1cc2c(cc1Br)C(C)(C)CCC2(C)C.O=CN1CCCCC1>>Cc1cc2c(cc1C=O)C(C)(C)CCC2(C)C,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20090221627A1,C=C[Sn](CCCC)(CCCC)CCCC.Fc1ccc(Br)cn1>>C=Cc1ccc(F)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20150322043A1,Cc1n[nH]cc1N.O=C(O)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1>>Cc1n[nH]cc1NC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.F[P-](F)(F)(F)(F)F,val
US20060211697A1,Cc1ccc(Oc2ccc(C(=N)NO)cc2)c(O)c1.O=C(c1ncc[nH]1)c1ncc[nH]1>>Cc1ccc(Oc2ccc(-c3noc(=O)[nH]3)cc2)c(O)c1,,C1CCOC1,,,,val
US20150232483A1,CC(C)(O)c1nc(N2C[C@H]3CSC(N)=N[C@@]3(c3cnccn3)C2)ncc1F.Cl>>CC(C)(O)c1nc(N2C[C@H]3CSC(N)=N[C@@]3(c3cnccn3)C2)ncc1F.Cl,,CC#N,,,,val
US20040110760A1,CN(C)CCn1c(=O)c2cc([N+](=O)[O-])ccc2c2cnc3cc4c(cc3c21)OCO4>>CN(C)CCn1c(=O)c2cc(N)ccc2c2cnc3cc4c(cc3c21)OCO4,[Ni],CCO,,NN,O,val
US20110301161A1,CC(C)(C)n1c(-c2cc(C#N)ccc2-n2cncn2)nc2cc(-c3cnc(N)nc3)ccc21.C[Si](C)(C)N=[N+]=[N-]>>CC(C)(C)n1c(-c2cc(-c3nn[nH]n3)ccc2-n2cncn2)nc2cc(-c3cnc(N)nc3)ccc21,,CN(C)C=O,,CCCC[Sn](=O)CCCC,,val
US04421753,CSC(=NC#N)N1CCN(Cc2ccc(F)cc2)CC1.NN>>Nc1nnc(N2CCN(Cc3ccc(F)cc3)CC2)[nH]1,,CCO,,O,,val
US20030087952A1,CCOC(=O)[C@H]1[C@@H](c2ccccc2)CC(=O)N1C>>CN1C(=O)C[C@H](c2ccccc2)[C@@H]1C(=O)O,,O,,Cl,,val
US20090181942A1,COC(=O)/C=C/c1cccn1-c1ccc(Cl)cc1C(=O)c1cccc2ccccc12>>COC(=O)CC1OC(c2cccc3ccccc23)c2cc(Cl)ccc2-n2cccc21,,CO,,[BH4-].[Na+],,val
US20140113901A1,BrCc1ccccc1.CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(O)cc(Cl)nn4c3-c3ccccc3)cc2)CCC1>>CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(OCc5ccccc5)cc(Cl)nn4c3-c3ccccc3)cc2)CCC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05136090,CCBr.COC(=O)CCCc1ccc(O)c(-c2cc(CCCC(=O)OC)ccc2O)c1>>CCOc1ccc(CCCC(=O)OC)cc1-c1cc(CCCC(=O)OC)ccc1O,[Cu],CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06787541B1,CCc1nc(C(=O)c2cccs2)c2sccc2n1>>CCc1nc(C(O)c2cccs2)c2sccc2n1,,CO,,,,val
US07348340B2,CN(C)c1cc(-c2cccc(F)c2)nc2ccc([N+](=O)[O-])cc12>>CN(C)c1cc(-c2cccc(F)c2)nc2ccc(N)cc12,[Pd],CCO,,[H][H],,val
US20110237565A1,C=O.CCOC(=O)c1cn2c(-c3cccs3)cnc(N3CCNCC3)c2n1>>CCOC(=O)c1cn2c(-c3cccs3)cnc(N3CCN(C)CC3)c2n1,,ClCCl,,CO,,val
US04122183,CCC(CC)C(=O)OC(=O)C(CC)CC.Cc1coc(N)n1>>CCC(CC)C(=O)Nc1nc(C)co1,,Cc1ccccc1,,,,val
US20150274721A1,C#CCBr.Oc1ccc(Cl)cc1>>C#CCOc1ccc(Cl)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04652652,CCOC(=O)C(C(=O)OCC)c1csc(N)n1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)C(C(=O)OCC)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,ClCCl,,CCN(CC)CC,Cl,val
US20120101134A1,CCOC(=O)CCc1cccc(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)c1C>>Cc1c(CCC(=O)O)cccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1,,CC(C)O,O,Cl,[Na+].[OH-],val
US20090181928A1,C=Cc1cccc(C(=O)O)c1.O=C(Cl)C(=O)Cl>>C=Cc1cccc(C(=O)Cl)c1,CN(C)C=O,ClCCl,,,,val
US20060173006A1,CC1(C)OB(c2ccc(NC(=O)c3c(F)cccc3F)cc2)OC1(C)C.COC(=O)c1ccc(C)c(Br)c1>>COC(=O)c1ccc(C)c(-c2ccc(NC(=O)c3c(F)cccc3F)cc2)c1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20120046268A1,COC(=O)CN=C=O.O=C(NC1CNCC(c2ccc(OC(F)(F)F)cc2)C1)c1ccccc1>>COC(=O)CNC(=O)N1CC(NC(=O)c2ccccc2)CC(c2ccc(OC(F)(F)F)cc2)C1,,C1CCOC1,,CCN(CC)CC,,val
US20100099695A1,COC(=O)[C@@H]1C[C@H](O)CN1C(=O)OC(C)(C)C.Oc1cc2ccccc2nc1Cl>>COC(=O)[C@@H]1C[C@@H](Oc2cc3ccccc3nc2Cl)CN1C(=O)OC(C)(C)C,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140336185A1,CC(C)(C)OC(=O)CNCc1ccc(I)cc1.COc1ccc(CC(=O)Nc2ccc(C(=O)O)cc2)c(C(F)(F)F)c1>>COc1ccc(CC(=O)Nc2ccc(C(=O)N(CC(=O)OC(C)(C)C)Cc3ccc(I)cc3)cc2)c(C(F)(F)F)c1,,CCOC(C)=O,CN(C)C=O,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20040044052A1,NC(=O)c1c(F)cccc1F.OCc1ccccc1>>NC(=O)c1c(F)cccc1OCc1ccccc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20080255230A1,O=C(O)C=Cc1ccccc1F>>O=C(O)CCc1ccccc1F,[Rh],C1CCOC1,,,,val
US20100331293A1,Cc1c(-c2cccnc2)nc2cc(F)ccc2c1Cl.Nc1cc(N2CCOCC2)cnc1N1CCOCC1>>Cc1c(-c2cccnc2)nc2cc(F)ccc2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1,,CN1CCCC1=O,,C1COCCO1,Cl,val
US20160096827A1,CC(=O)Cl.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@H]1CCNC[C@H]1F>>CC(=O)N1CC[C@H](Oc2ccc(-c3ncnc(Nc4ccc(N5CCN(C6COC6)CC5)cc4)n3)cc2C#N)[C@H](F)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160152626A1,COc1cc2c(cc1C#N)-c1c(c(C(=O)N3CCOCC3(C)C)nn1-c1ccsc1)CO2>>COc1cc2c(cc1CN)-c1c(c(C(=O)N3CCOCC3(C)C)nn1-c1ccsc1)CO2,[Ni],,,CO,,val
US04221788,CN1CCCCCC1=O.COS(=O)(=O)OC>>COC1=[N+](C)CCCCC1.COS(=O)(=O)[O-],,CCOCC,,,,val
US20110112080A1,CC(C)(C)OC(=O)N1[C@@H](C[C@@H](O)C(F)(F)F)COC1(C)C.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)N1[C@@H](C[C@@H](Oc2ccc([N+](=O)[O-])cc2)C(F)(F)F)COC1(C)C,,C1CCOC1,ClCCl,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20150175600A1,Cn1c(-c2cc3cccnc3n2CC(F)(F)F)nc2cc(C(=O)N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)ccc21>>Cn1c(-c2cc3cccnc3n2CC(F)(F)F)nc2cc(C(=O)N3CCC[C@@H](N)C3)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050032846A1,CCC(CC)Nc1cc(C)nc(Cl)c1[N+](=O)[O-].Cc1cc(C)c(O)c(C)c1>>CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1[N+](=O)[O-],,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20120115898A1,C[Si](C)(C)CCOCn1nc(NC2CCN(S(C)(=O)=O)CC2)c2nc(-c3c(F)cccc3F)c3cc(C#N)ccc3c21>>CS(=O)(=O)N1CCC(Nc2n[nH]c3c2nc(-c2c(F)cccc2F)c2cc(C#N)ccc23)CC1,,Cl,,O,[Na+].[OH-],val
US20160176850A1,COC(=O)c1cc(Cl)nc(SC)n1.c1cnc2[nH]cc(C3CCNCC3)c2c1>>COC(=O)c1cc(N2CCC(c3c[nH]c4ncccc34)CC2)nc(SC)n1,,CO,,CCN(C(C)C)C(C)C,Cl,val
US20070099975A1,BrBr.CC(=O)c1ccc(CC(C)C)cc1>>CC(C)Cc1ccc(C(=O)CBr)cc1,,CCO,,Cc1ccccc1,,val
US20120208791A1,Brc1cnn(C2CCNCC2)c1.CC(=O)OC(C)=O>>CC(=O)N1CCC(n2cc(Br)cn2)CC1,,c1ccncc1,,Cl,,val
US20050267170A1,CB(O)O.COC(=O)c1cc(F)cnc1Cl>>COC(=O)c1cc(F)cnc1C,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20050043535A1,Cc1cc(NC(=O)N[C@H](C(=O)N2CCC(Cc3ccccc3)CC2)C(C)C)c2ccccc2n1>>Cc1cc(NC(=O)Nc2cc(C)nc3ccccc23)c2ccccc2n1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050143416A1,O=[N+]([O-])c1cc(Cl)c(Cl)c(Cl)c1.Oc1cnc2ccccc2c1>>O=[N+]([O-])c1cc(Cl)c(OC2C=Nc3ccccc3C2)c(Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130303517A1,COC(=O)c1cnc2nc(-c3ccccc3)c(CCCCC(=O)OC(C)(C)C)nc2c1>>COC(=O)c1cnc2nc(-c3ccccc3)c(CCCCC(=O)O)nc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060111362A1,CC#CCn1c(=O)[nH]c2nc(Cl)nc(Cl)c21.CC(C)(C)C(=O)OCCl>>CC#CCn1c(=O)n(COC(=O)C(C)(C)C)c2nc(Cl)nc(Cl)c21,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US04683239,Brc1ccc([C@@H]2CC[C@@H]3CCCCN32)cc1.Nc1cccc(S)c1>>Nc1cccc(Sc2ccc([C@@H]3CC[C@@H]4CCCCN43)cc2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20100160369A1,Cc1ccc(S(=O)(=O)OCC2COC(=O)N2)cc1.Oc1cc(Cl)c(-c2nnc(-c3cn4cc(C(F)(F)F)cc(Cl)c4n3)o2)cc1Cl>>O=C1NC(COc2cc(Cl)c(-c3nnc(-c4cn5cc(C(F)(F)F)cc(Cl)c5n4)o3)cc2Cl)CO1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080280875A1,CCOC(=O)c1cc(OC(C)=O)c2oc(C)cc2c1>>CCOC(=O)c1cc(O)c2oc(C)cc2c1,,CCO,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US04331666,CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(COC(C)=O)CS[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1.Nc1cc(S)nn2nnnc12>>CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3cc(N)c4nnnn4n3)CS[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,CC#N,,,,val
US20150328228A1,CS(=O)(=O)OCCN1CCNC1=O.O=S(=O)(c1ccccc1)n1cc(-c2cnn(CC3CCNCC3)c2)c2cc(F)c(F)cc21>>O=C1NCCN1CCn1cc(-c2cn(S(=O)(=O)c3ccccc3)c3cc(F)ccc23)cn1,,CCO,,O=C([O-])O.[Na+],,val
US20130085123A1,CN1C(=O)c2c(nn(Cc3ccc(-n4cccn4)cc3)c2Cl)N2C1=N[C@@H]1CCC[C@@H]12.Oc1ccccc1>>CN1C(=O)c2c(nn(Cc3ccc(-n4cccn4)cc3)c2Oc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05041436,CN(C)c1ccc(S(=O)(=O)Cl)cc1.NCCCCC(=O)O>>CN(C)c1ccc(S(=O)(=O)NCCCCC(=O)O)cc1,,O,,C1CCOC1,[Na+].[OH-],val
US20100234351A1,CC(C)(C)OC(=O)NCCCn1cccn1.Cl>>Cl.NCCCn1cccn1,,C1CCOC1,,,,val
US04242507,CCCCS(=O)(=O)Cl.On1nnc2ccccc21>>CCCCS(=O)(=O)On1nnc2ccccc21,,c1ccccc1,,CCN(CC)CC,,val
US20120010189A1,CCC1(O)CN(C(=O)OC(C)(C)C)C1.O=C(O)C(F)(F)F>>CCC1(O)CNC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20100292208A1,O=S(Cl)Cl.OCc1cc2ccc(Oc3nc4ncccc4s3)cc2s1>>ClCc1cc2ccc(Oc3nc4ncccc4s3)cc2s1,,ClCCl,,,,val
US20030069434A1,CN(CCCCCCCCC(F)(F)C(F)(F)F)CCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)C(=O)CC[C@H]3[C@H]12>>CN(CCCCCCCCC(F)(F)C(F)(F)F)CCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12,,CO,,[BH4-].[Na+],,val
US20150239837A1,CCOP(=O)(OCC)c1ccc2c(C(C)=O)cn(CC(=O)N3C[C@H](F)C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1>>CCOP(=O)(O)c1ccc2c(C(C)=O)cn(CC(=O)N3C[C@H](F)C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1,,ClCCl,,C[Si](C)(C)Br,,val
US04985419,CC(CN1CCCC1)N1c2ccccc2Sc2ccc(C(N)=S)cc21.NC1CCCCC1N>>CC(CN1CCCC1)N1c2ccccc2Sc2ccc(C3=NC4CCCCC4N3)cc21,,CCOC(C)=O,,,,val
US08304419B2,C[Si](C)(C)CCOCn1c(N=[N+]=[N-])nc(Br)c1C(=O)NCc1ccc(Br)c(Oc2cc(Cl)cc(C#N)c2)c1F>>C[Si](C)(C)CCOCn1c(N)nc(Br)c1C(=O)NCc1ccc(Br)c(Oc2cc(Cl)cc(C#N)c2)c1F,[Pd],C1CCOC1,,,,val
US20060100194A1,CCOC(=O)C1CC(=O)Nc2ccc(I)cc2C1=O>>O=C1CCC(=O)c2cc(I)ccc2N1,,CS(C)=O,,O,[Cl-].[Na+],val
US20130295141A1,COc1ccc(-c2ccc(CC[C@H]3O[C@@H](O)[C@@H](O)[C@H]3CCN3C(=O)c4ccccc4C3=O)cc2)cn1>>COc1ccc(-c2ccc(CC[C@@H](OC=O)[C@@H](C=O)CCN3C(=O)c4ccccc4C3=O)cc2)cn1,,CO,,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20070213314A1,FC(F)(F)c1ccc(Br)cc1.O=C=O>>O=C(O)c1cc(C(F)(F)F)ccc1Br,,C1CCOC1,,CC1(C)CCCC(C)(C)N1,[Li]CCCC,val
US05859007,BrCc1ccccc1.COC(=O)c1cc(C)n[nH]1>>COC(=O)c1cc(C)nn1Cc1ccccc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US05516629,BrBr.O=c1ccc2ccc(OCCCBr)cc2o1>>O=c1oc2cc(OCCCBr)ccc2cc1Br,,C1CCOC1,,,,val
US20120029190A1,O=C(NC1CCN(C(=O)OCc2ccccc2)CCC1O)c1ccccn1>>O=C(NC1CCN(C(=O)OCc2ccccc2)CCC1=O)c1ccccn1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20070105810A1,CCCCCCCCN.O=C(Br)CBr>>CCCCCCCCNC(=O)CBr,,CCOCC,,O,,val
US20080293701A1,CCCCC(C)(C)C(=O)NC[C@@H]1OC(C)(C)N(C(=O)OC(C)(C)C)[C@H]1C[C@H](Cc1ccc(CC)c(OCCCOC)c1)C(C)C>>CCCCC(C)(C)C(=O)NC[C@H](O)[C@@H](N)C[C@H](Cc1ccc(CC)c(OCCCOC)c1)C(C)C,,CO,Cl,,,val
US20080306096A1,O=C(O)c1cc(F)cc(C2CC2)c1>>CC(C)c1cc(F)cc(C(=O)O)c1,O=[Pt]=O,CC(=O)O,,[H][H],,val
US20030149281A1,CC(C)(C#N)C(O)CC[Si](C)(C)C(C)(C)C.O>>CC(C)(C#N)C(O)CCO,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04824468,CC(C)CC(=O)Cl.CCC1CNC(c2cccc(C#N)c2)O1>>CCC1CN(C(=O)CC(C)C)C(c2cccc(C#N)c2)O1,,ClCCl,,c1ccncc1,,val
US20150336962A1,COc1ccc(Cl)cc1-c1nc(Br)sc1NC(=O)c1cnn2cccnc12>>O=C(Nc1sc(Br)nc1-c1cc(Cl)ccc1O)c1cnn2cccnc12,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US03991050,CO.COc1cc(C(=O)O)cc(OC)c1O>>COC(=O)c1cc(OC)c(O)c(OC)c1,O=S(=O)(O)O,,,,,val
US20120264731A1,CN1CCNCC1.O=C(O)c1cc([C@H]2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1>>CN1CCN(C(=O)c2cc([C@H]3CCCN3c3cc(F)cc(F)c3)c3oc(N4CCOCC4)cc(=O)c3c2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060229336A1,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2ccccc2)CCN(C(=NC#N)Oc2ccccc2)CC1.N>>Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2ccccc2)CCN(C(N)=NC#N)CC1,,CO,,,,val
US06169101A,C1CCOC1.CC(C)(C)c1cccc(Br)n1.CN(C)C=O>>CC(C)(C)Oc1cccc(C=O)n1,,CCCCCC,,[Li]CCCC,,val
US20150141406A1,COc1ncc(C#N)c2c(-c3ccccc3C)c[nH]c12.NC(=O)c1cc(Br)cs1>>Cc1ccccc1-c1cn(-c2csc(C(N)=O)c2)c2c(=O)[nH]cc(C#N)c12,[Cu]I,O,,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US05763463,CCc1nccc(NC(=O)OC)c1Cl.O=C(Cl)Cc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1>>CCc1nccc(N(C(=O)Cc2ccc(Oc3ccc(C(F)(F)F)cn3)cc2)C(=O)OC)c1Cl,,CC(=O)N(C)C,,[H-].[Na+],,val
US20130150401A1,CC1(C)CO1.CS(=O)(=O)c1ccc(-c2ccc3c(c2)CC(C2CCNCC2)O3)cc1>>CC(C)(O)CN1CCC(C2Cc3cc(-c4ccc(S(C)(=O)=O)cc4)ccc3O2)CC1,,CO,,CCN(C(C)C)C(C)C,Cl,val
US05739162,Cc1cccc(NC(=O)NCC(=O)N(CC(=O)OC(C)(C)C)c2ccccc2C(=O)C2CCN(C(=O)OCc3ccccc3)CC2)c1>>Cc1cccc(NC(=O)NCC(=O)N(CC(=O)OC(C)(C)C)c2ccccc2C(=O)C2CCNCC2)c1,[Pd],,,,,val
US04978753,C#CC(=O)OC.CS(=O)(=O)c1ccc(C2=NCC(N)=Nc3ccc(C#N)cc32)cc1>>CS(=O)(=O)c1ccc(C2=NCc3nc(=O)ccn3-c3ccc(C#N)cc32)cc1,,CO,,,,val
US20060025474A1,CCOC(=O)CCCCCOc1ccc(C(CC)(CC)c2ccc(C#CC3(O)CCCC3)c(C)c2)cc1C>>CCC(CC)(c1ccc(C#CC2(O)CCCC2)c(C)c1)c1ccc(OCCCCCC(=O)O)c(C)c1,,CO,,Cl,[K+].[OH-],val
US04863947,COC(=O)C1(C)CNN=C1c1ccc(Cl)cc1.O=C=Nc1ccc(C(F)(F)F)cc1>>COC(=O)C1(C)CN(C(=O)Nc2ccc(C(F)(F)F)cc2)N=C1c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20050014812A1,CCOC(=O)C(C)(C)CCOc1ccc2nc(C)n(Cc3ccc(Cl)cc3Cl)c2c1>>Cc1nc2ccc(OCCC(C)(C)C(=O)O)cc2n1Cc1ccc(Cl)cc1Cl,,CCO,,Cl,[Na+].[OH-],val
US20160272645A1,CC(C)(C)OC(=O)NCCOS(C)(=O)=O.Nc1ncnc2[nH]nc(I)c12>>CC(C)(C)OC(=O)NCCn1nc(I)c2c(N)ncnc21,,CN(C)C=O,,[H-].[Na+],,val
US20050038104A1,CCOc1ccc(N)c2sc(C(N)=O)c(N)c12.CS(=O)(=O)Cl>>CCOc1ccc(NS(C)(=O)=O)c2sc(C(N)=O)c(N)c12,,C1CCOC1,O,c1ccncc1,,val
US20100087424A1,COC(OC)N(C)C.Nc1ccc(Br)cn1>>N=CNc1ccc(Br)cn1,,CN(C)C=O,,,,val
US20100081644A1,COC1CCC(CS(=O)(=O)C(C)(C)C(=O)Nc2cc(C(C)(C)COC3CCCCO3)no2)CC1>>COC1CCC(CS(=O)(=O)C(C)(C)C(=O)Nc2cc(C(C)(C)CO)no2)CC1,,CCOCC,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,,val
US20020037905A1,O=c1[nH]nc(-c2ccccc2[N+](=O)[O-])o1>>Nc1ccccc1-c1n[nH]c(=O)o1,[Pd],CCO,,,,val
US20140249199A1,COC(=O)C(=[N+]=[N-])c1ccc(Cl)c(Cl)c1.Cc1ccco1>>COC(=O)/C(=C/C=C\C(C)=O)c1ccc(Cl)c(Cl)c1,,CCCCCC,,,,val
US04264605,Nc1ccc(Br)cn1.Sc1ccc(Cl)cc1>>Nc1ccc(Sc2ccc(Cl)cc2)cn1,[Cu],CO,,C[O-].[Na+],,val
US20080021012A1,CN1CCNCC1.CON(C)C(=O)CCCCl>>CON(C)C(=O)CCCN1CCN(C)CC1,,CS(C)=O,,,,val
US04159331,CCCc1cc(CCC)cc(N2CCNCC2)c1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CCCc1cc(CCC)cc(N2CCN(S(=O)(=O)c3ccc([N+](=O)[O-])cc3)CC2)c1,,CCN(CC)CC,,,,val
US07465806B2,CCOC(=O)c1c(C)c(S(=O)(=O)N2CCCOCC2)c(C)n1Cc1cc(-c2ccc(Cl)s2)on1>>Cc1c(S(=O)(=O)N2CCCOCC2)c(C)n(Cc2cc(-c3ccc(Cl)s3)on2)c1C(=O)O,,C1CCOC1,O,,,val
US04459232,Nc1ccccc1Cc1ncc[nH]1.O=C(Cl)Oc1ccccc1>>O=C1Nc2ccccc2Cc2nccn21,,CC#N,,CCN(CC)CC,O,val
US04636512,CC(C)(C)OC(=O)NCC(=O)Nc1c(C(=O)CC(=O)Nc2nccs2)cccc1C(F)(F)F>>CC(C)(C)OC(=O)NCc1nc2c(C(F)(F)F)cccc2c(O)c1C(=O)Nc1nccs1,CN(C)c1ccncc1,O,,C1CCOC1,,val
US20060287300A1,CI.COC1=CC(=O)C(O)(CCC(C)C)c2ccccc21>>COC1=CC(=O)C(CCC(C)C)(OC)c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20030181465A1,Nc1cnc(Cl)nc1.O=C(Cl)c1ccc(F)c(F)c1>>O=C(Nc1cnc(Cl)nc1)c1ccc(F)c(F)c1,,C1CCOC1,,CCN(CC)CC,,val
US20010021714A1,c1ccc(SSc2ccccc2)cc1.c1ccoc1>>c1ccc(Sc2ccco2)cc1,,C1CCOC1,CCOCC,[Li]C(C)(C)C,,val
US20060287329A1,C1CCNC1.COC(=O)[C@@H]1CC[C@@H](C(=O)O)CC1>>COC(=O)[C@@H]1CC[C@@H](C(=O)N2CCCC2)CC1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US06423840B1,COC(=O)CN1C(=O)[C@@H](NC(=O)c2ccccc2)CNc2ccccc21.O=C(Cl)CCc1ccccc1>>COC(=O)CN1C(=O)[C@@H](NC(=O)c2ccccc2)CN(C(=O)CCc2ccccc2)c2ccccc21,,ClCCl,,CCN(CC)CC,,val
US20020122874A1,CC(C)(Cl)CCl.CN(C)C=O.Nc1nc2nc[nH]c2c(=O)[nH]1>>CC(C)C(=O)Nc1nc2nc[nH]c2c(=O)[nH]1,,CO,,CCN(CC)CC,,val
US20060094696A1,CCc1cc2c(cc1OCOC)CCC1C2CCC2(C)C(=O)CCC12>>CCc1cc2c(cc1OCOC)CCC1C2CCC2(C)C(O)CCC12,,C1CCOC1,,CO,[BH4-].[Na+],val
US20150259346A1,FC(F)C1CCNc2ccccc21.NC(=O)CI>>NC(=O)CN1CCC(C(F)F)c2ccccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,[Na+].[OH-],val
US20100184739A1,C[C@H]1CCCN1c1ccc([N+](=O)[O-])c(C(F)(F)F)n1>>C[C@H]1CCCN1c1ccc(N)c(C(F)(F)F)n1,,CO,,[BH4-].[Na+],,val
US20090137577A1,CC(O)C1CCCCC1.O=Cc1ccc(O)cc1>>CC(Oc1ccc(C=O)cc1)C1CCCCC1,,C1CCOC1,O,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06977254B2,Cc1cc(C(=O)N2Cc3ccc(C(=O)C(Cl)(Cl)Cl)n3Cc3ccccc32)ccc1C1=CCCCC1.[OH-]>>Cc1cc(C(=O)N2Cc3ccc(C(=O)O)n3Cc3ccccc32)ccc1C1=CCCCC1,,CC(C)=O,,Cl,,val
US20050043379A1,BrCCCOc1ccc(OCc2ccccc2)cc1>>Oc1ccc(OCCCBr)cc1,[Pd],C1CCOC1,,,,val
US20090036440A1,CI.COc1ccc(C)c(Nc2ccnc(Cl)n2)c1>>COc1ccc(C)c(N(C)c2ccnc(Cl)n2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090247567A1,COC(=O)CS.O=CC1=C(Cl)c2ccc(Br)cc2OCC1>>COC(=O)c1cc2c(s1)-c1ccc(Br)cc1OCC2,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US05180741,N#Cc1cccc2c1CCC2O>>N#Cc1cccc2c1CCC2,,ClCCCl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060270651A1,COCCl.O=[N+]([O-])c1cc(O)cc(C(F)(F)F)c1>>COCOc1cc(N)cc(C(F)(F)F)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04560771,CC1=Cc2cc(Br)cc(S(N)(=O)=O)c2OS1(=O)=O.COc1nc(C)nc(N(C(=O)[O-])c2ccccc2)n1>>COc1nc(C)nc(NC(=O)NS(=O)(=O)c2cc(Br)cc3c2OS(=O)(=O)C(C)=C3)n1,,C1COCCO1,,C1CCC2=NCCCN2CC1,,val
US20140288041A1,CC1(C)OB(c2ccc(CN3CCOCC3)cc2)OC1(C)C.Cc1cc(C)c(CNC(=O)c2cc(Br)cc(N(CC(F)F)C3CCOCC3)c2C)c(=O)[nH]1>>Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(CN4CCOCC4)cc3)cc(N(CC(F)F)C3CCOCC3)c2C)c(=O)[nH]1,,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20150329535A1,Nc1ccccc1-c1ccccc1.O=C1CCC(=O)N1Br>>Nc1ccc(Br)cc1-c1ccccc1,,CN(C)C=O,,O,,val
US20090018132A1,NC1CC1.[N-]=[N+]=Nc1c(Br)cc(Cl)cc1C=O>>Clc1cc(Br)c2nn(C3CC3)cc2c1,,ClCCl,,,,val
US20020147333A1,CC(=O)c1cc(C)n(CCOC(=O)Cl)n1.CNC>>CC(=O)c1cc(C)n(CCOC(=O)N(C)C)n1,,ClCCl,,Cl,c1ccncc1,val
US20050043338A1,COc1cccc(B(O)O)c1F.Cc1c(Br)c(=O)n(C[C@H](NC(=O)OC(C)(C)C)C2CCCCC2)c(=O)n1Cc1c(F)cccc1F>>COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](NC(=O)OC(C)(C)C)C3CCCCC3)c2=O)c1F,,CCO,COCCOC,,,val
US20140303127A1,CCOC(=O)COc1ccc(CO)cc1.CNCCN(C)[C@@H]1CC[C@@H](OC(=O)C(O)(c2cccs2)c2cccs2)CC1>>CN(CCN(C)[C@@H]1CC[C@@H](OC(=O)C(O)(c2cccs2)c2cccs2)CC1)C(=O)COc1ccc(CO)cc1,,CCO,,O=S(=O)([O-])[O-].[Mg+2],,val
US20160060257A1,COc1ccc(F)cc1-c1ccnc2[nH]c(C3(O)CN(C(=O)OC(C)(C)C)C3)cc12>>COc1ccc(F)cc1-c1ccnc2[nH]c(C3(O)CNC3)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060084689A1,CCC[C@H](N)C(=O)Nc1ncc(C(C)C)s1.O=C1CCc2c(F)cc(F)cc2C1>>CCC[C@H](NC1CCc2c(F)cc(F)cc2C1)C(=O)Nc1ncc(C(C)C)s1,,CCOC(C)=O,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130053555A1,O=C(Cl)c1ccccc1Br.c1ccc(-c2occ3c2[nH]c2ccccc23)cc1>>O=C(c1ccccc1Br)n1c2ccccc2c2coc(-c3ccccc3)c21,,C1CCOC1,,C1COCCOCCOCCOCCO1,[H-].[Na+],val
US20040106622A1,COC(=O)[C@H](CNC(=O)C1CCN(c2cccc(NC3=NCCCN3)c2)CC1)NC(=O)OC(C)C>>CC(C)OC(=O)N[C@@H](CNC(=O)C1CCN(c2cccc(NC3=NCCCN3)c2)CC1)C(=O)O,,CO,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US05393732,CC(C)C(F)(/C=C/c1ncn(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1)C(C)C.O=[PH](O)O>>CC(C)C(F)(CCc1ncn(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1)C(C)C.O=[PH](O)O,[Pd],CC(C)O,,,,val
US20070244132A1,COC(=O)c1ccc(F)cc1.CSc1ncnc2cn[nH]c12>>COC(=O)c1ccc(-n2cc3ncnc(SC)c3n2)cc1,,CN1CCCC1=O,,O,O=C([O-])[O-].[K+].[K+],val
US04859700,CCCC1C(=O)Oc2ccccc21.O=C(CBr)OCc1ccccc1>>CCCC1(CC(=O)OCc2ccccc2)C(=O)Oc2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20150291549A1,CC(=O)Nc1cc(CO)ccn1.O=S(Cl)Cl>>CC(=O)Nc1cc(CCl)ccn1.Cl,,ClCCl,,,,val
US20160122336A1,C[C@H]1CCCCN1C(=O)c1nc(C(=O)NCC(C)(C)C(N)=O)sc1-c1ccc(C(O)(C(F)(F)F)C(F)(F)F)c(Cl)c1Cl>>C[C@H]1CCCCN1C(=O)c1nc(C(=O)NCC(C)(C)C#N)sc1-c1ccc(C(O)(C(F)(F)F)C(F)(F)F)c(Cl)c1Cl,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20100204274A1,CCOC(=O)/C(C)=C(/C)N>>CCOC(=O)C(C)C(C)N,,CC#N,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20080181866A1,O=C(Cl)OCc1ccccc1.O=C(O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1>>O=C(O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)OCc1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04873236,NCCN1CCCC(CN2CCCCCC2)C1.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>O=C1Nc2cccnc2N(C(=O)NCCN2CCCC(CN3CCCCCC3)C2)c2ccccc21,,CC#N,,,,val
US20040087577A1,CCOC(=O)c1cccnc1Cl.NOCc1ccccc1>>CCOC(=O)c1cccnc1NOCc1ccccc1,,C1COCCO1,,CCN(C(C)C)C(C)C,Cl,val
US04223142,CCCCNc1nc2cnnc(OCC)c2cc1C(=O)OCC.Nc1cccc(C(F)(F)F)c1>>CCOC(=O)c1cc(C#N)c(C)nc1Nc1cccc(C(F)(F)F)c1,,CCN(CC)CC,,,,val
US20090286807A1,Cc1c(F)cccc1NCC(C)(C)NC(=O)OC(C)(C)C.O=C(Br)CBr>>Cc1c(F)cccc1N(CC(C)(C)NC(=O)OC(C)(C)C)C(=O)CBr,,CC(=O)N(C)C,,O=C([O-])O.[Na+],,val
US20080269194A1,COc1ccc(CCl)cc1.Oc1ccc(Br)cc1>>COc1ccc(COc2ccc(Br)cc2)cc1,,CC(C)=O,,[I-].[K+],,val
US20140038999A1,C=C(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O.C[Si](C)(C)C=[N+]=[N-]>>C=C(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)OC,,C1CCOC1,,,,val
US20040220404A1,CCOC(COc1ccc(N)cc1OC)OCC.O=C(O)c1ccc(Cl)cc1[N+](=O)[O-]>>CCOC(COc1ccc(NC(=O)c2ccc(Cl)cc2[N+](=O)[O-])cc1OC)OCC,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20090286790A1,Br[Mg]CC1CCCCC1.CC(C)(C)O[K].COc1ccncc1.O=C(Cl)Oc1ccccc1>>CC(C)(C)OC(=O)N1C=CC(=O)CC1CC1CCCCC1,,C1CCOC1,,,,val
US20160108036A1,CCOC(=O)c1c[nH]nc1C1CC1.COc1cc(CBr)cnc1Cl>>CCOC(=O)c1cn(Cc2cnc(Cl)c(OC)c2)nc1C1CC1,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20090298834A1,CC(C)(C)C(=O)CN[C@@H]1CC[C@H](CC(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1>>CC(C)(C)C(O)CN[C@@H]1CC[C@H](CC(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1,,CO,,[BH4-].[Na+],,val
US04013762,C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43CO)[C@@H]1CCC2=O>>C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C=O)[C@@H]1CCC2=O,,CC(C)=O,,O=S(=O)(O)O,O=[Cr](=O)=O,val
US20140275043A1,N#CCC(=O)c1cccc(OCC2CCOCC2)c1>>NCC[C@@H](O)c1cccc(OCC2CCOCC2)c1,,C1CCOC1,,,,val
US07105507B2,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[Si](C)(C)CCOCn1ccnc1CNCCCl>>CC(C)(C)OC(=O)N(CCCl)Cc1nccn1COCC[Si](C)(C)C,,ClCCl,,,,val
US20150119362A1,COC(=O)Cc1ccc(Cc2nc(-c3cccc(Cl)c3)nc3c2CCC3)cc1.N>>NC(=O)Cc1ccc(Cc2nc(-c3cccc(Cl)c3)nc3c2CCC3)cc1,,CO,,[Cl-].[NH4+],,val
US07375227B2,CCOC(=O)C1(Cc2ccccc2)CCN(CCN)CC1>>NCCN1CCC(Cc2ccccc2)(C(=O)O)CC1,,Cl,,,,val
US20120178748A1,Cc1cc(C)c(S(=O)(=O)ON)c(C)c1.Nc1ccccn1>>Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1.Nn1ccccc1=[NH2+],,ClCCl,,,,val
US06376530B1,Cc1cc(Cl)ccc1C#N.NC(=O)CCC(=O)NBr>>N#Cc1ccc(Cl)cc1CBr,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20070173519A1,CCOc1ccc(N(C(=O)OC(C)(C)C)c2c(CCCO[Si](C)(C)C(C)(C)C)c(N[C@H]3CCCN(C(=O)OC(C)(C)C)C3)nc3ccnn23)cc1>>CCOc1ccc(N(C(=O)OC(C)(C)C)c2c(CCCO)c(N[C@H]3CCCN(C(=O)OC(C)(C)C)C3)nc3ccnn23)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05190934,CCO[PH](=O)CC1CCCCC1.CI>>CCOP(C)(=O)CC1CCCCC1,,C1CCOC1,,O,[H-].[Na+],val
US20130035325A1,CNC(=O)CC#N.COc1cc(-c2n[nH]c3ccc(C=O)cc23)cc(OC)c1OC>>CNC(=O)C(C#N)=Cc1ccc2[nH]nc(-c3cc(OC)c(OC)c(OC)c3)c2c1,,C1CCOC1,CCOC(C)=O,C1CCC2=NCCCN2CC1,,val
US06040270,CC(C)Oc1cc(NN)c(F)cc1Cl.CCOC(=O)CC=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=C(C(Br)Br)C(F)(F)F>>Cc1c(C(F)(F)F)cnn(-c2cc(OC(C)C)c(Cl)cc2F)c1=O,,CCOCC,O,CC(=O)[O-].[Na+],,val
US04954499,CC1CC(=O)NN=C1c1ccc(N)c([N+](=O)[O-])c1>>CC1CC(=O)NN=C1c1ccc(N)c(N)c1,[Pd],CO,,,,val
US20080032995A1,COc1ccc(C(=O)C=CN(C)C)c(O)c1.O=C1CCC(=O)N1I>>COc1ccc2c(=O)c(I)coc2c1,,ClC(Cl)Cl,,CO,,val
US20030078251A1,CCOC(=O)CSc1nc2cc(NC(=O)C[C@H]3O[C@H](c4cccc(OC)c4OC)c4cc(Cl)ccc4N(CC(C)(C)COC(C)=O)C3=O)ccc2[nH]1>>COc1cccc([C@H]2O[C@H](CC(=O)Nc3ccc4[nH]c(SCC(=O)O)nc4c3)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US06294555B1,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCNCC2)CC1.C[Si](C)(C)N=C=O>>COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(N)=O)CC2)CC1,,ClCCl,,,,val
US20030018207A1,CCOC(Cc1ccc(OCCc2ccc(NC(=O)OC(C)(C)C)cc2)cc1)C(N)=O>>CCOC(C#N)Cc1ccc(OCCc2ccc(NC(=O)OC(C)(C)C)cc2)cc1,,C1COCCO1,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US20070232590A1,Fc1ccc(I)cc1.Oc1ccc2c(c1)CCN(C1CCC1)CC2>>Ic1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130310395A1,CCCC[Sn](CCCC)(CCCC)c1[nH]ncc1F.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1ccc(F)c(Br)c1>>O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1ccc(F)c(-c2[nH]ncc2F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US05939439,N#Cc1ccc(C(CCN=[N+]=[N-])n2ccnc2)cc1>>N#Cc1ccc(C(CCN)n2ccnc2)cc1,[Pd],CO,,,,val
US20050143588A1,CC(=O)Oc1cccc(-c2coc3c(C)c(OC(C)=O)ccc3c2=O)c1>>CC(=O)Oc1cccc(C2COc3c(ccc(OC(C)=O)c3C)C2O)c1,[Pd],CO,,,,val
US20070149546A1,Fc1cccc2ncnc(Cl)c12.Nc1ccc(O)c(F)c1>>Oc1ccc(Nc2ncnc3cccc(F)c23)cc1F,,CC(C)O,,,,val
US20090137561A1,CI.COC(=O)c1ccc(-c2cc(OC)ncc2F)c(C2(CO)CCCC2)c1>>COCC1(c2cc(C(=O)OC)ccc2-c2cc(OC)ncc2F)CCCC1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20090131458A1,BrCCC1CCOCC1.CCCCOc1nc(N)c2nc(OC)[nH]c2n1>>CCCCOc1nc(N)c2nc(OC)n(CCC3CCOCC3)c2n1,,CN(C)C=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US06444679B1,COc1cccc(C2(c3ncc(C(=O)NC(C)(C)CO)cn3)CCN(Cc3ccccc3)CC2)c1>>COc1cccc(C2(c3ncc(C4=NC(C)(C)CO4)cn3)CCN(Cc3ccccc3)CC2)c1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040162352A1,COc1ccc2c(c1)CC(N1C(=O)c3ccccc3C1=O)C2>>O=C1c2ccccc2C(=O)N1C1Cc2ccc(O)cc2C1,,ClCCl,,BrB(Br)Br,,val
US20130079357A1,COc1c(C)cc(C(=O)Nc2c(O)nc(SC)nc2O)cc1C>>COc1c(C)cc(-c2nc3c(O)nc(SC)nc3o2)cc1C,,O=P(Cl)(Cl)Cl,,,,val
US20150274665A1,CC(=O)Cl.CCc1[nH]cc(C(NC2CC2)C(F)(F)F)c(=O)c1O>>CCc1[nH]cc(C(NC2CC2)C(F)(F)F)c(=O)c1O.Cl,,CO,,,,val
US20130157996A1,C=C[Sn](CCCC)(CCCC)CCCC.O=[N+]([O-])c1ccc(Cl)nc1OCc1ccccc1>>C=Cc1ccc([N+](=O)[O-])c(OCc2ccccc2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US05159077,CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21.O=CN1CCC(CBr)CC1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(CC4CCN(C=O)CC4)CC3)cc21,,CN(C)C=O,,CCN(CC)CC,,val
US20070213331A1,CCCSc1cc(C(=O)OC)cc(Cl)n1.CC[C@H](C)N>>CCCSc1cc(C(=O)OC)cc(NC(C)CC)n1,,CCOCC,Cc1ccccc1,c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1,O=C([O-])[O-].[Cs+].[Cs+],val
US20140371199A1,CN1CCNCC1.COc1cc(Br)ccc1C(=O)O>>COc1cc(Br)ccc1C(=O)N1CCN(C)CC1,,CCOC(C)=O,CN(C)C=O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120077781A1,Cc1cc(NCCCCCCC(=O)O)c([N+](=O)[O-])cc1C>>Cc1cc(N)c(NCCCCCCC(=O)O)cc1C,[Pd],CO,,[BH4-].[Na+],,val
US05298652,CCCCCCCCCCCCCCCCCCOc1ccc(C(=O)C(=O)O)cc1.CCOC(=O)CNCC(=O)OCC>>CCCCCCCCCCCCCCCCCCOc1ccc(C(=O)C(=O)N(CC(=O)OCC)CC(=O)OCC)cc1,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US04496572,Cc1c(CO)sc2cc(Br)ccc12.O=S(Cl)Cl>>Cc1c(CCl)sc2cc(Br)ccc12,c1ccncc1,ClC(Cl)Cl,,,,val
US20060264387A1,NCc1cccnc1.Nc1ncnc2c1nc(Br)n2CCO>>Nc1ncnc2c1nc(NCc1cccnc1)n2CCO,,O,,,,val
US20110111046A1,COC(=O)c1ccnc(C(=O)/C=C\N(C)C)c1.NN>>O=C(O)c1ccnc(-c2cc[nH]n2)c1,,CCO,,O,,val
US20060166997A1,COB(OC)OC.COc1cc(I)c(F)cc1C>>COc1cc(B(O)O)c(F)cc1C,,C1CCOC1,,[Li]CCCC,,val
US20110190269A1,COc1cc(Br)ccc1-n1cnc(C)c1.Nc1nc2c(C3=CCOCC3)cccn2n1>>COc1cc(Nc2nc3c(C4=CCOCC4)cccn3n2)ccc1-n1cnc(C)c1,,CO,ClCCl,,,val
US20060189629A1,CC(=O)Nc1cccc(-n2cnc3cc(C(=O)NCc4cccnc4)ccc32)c1>>Nc1cccc(-n2cnc3cc(C(=O)NCc4cccnc4)ccc32)c1,,Cl,,,,val
US20020156077A1,COc1ccc(C(=O)c2cc(C#N)ccc2-c2c(C)cc(OC)cc2C)cc1.O=C1CCC(=O)N1Br>>COc1ccc(C(=O)c2cc(C#N)ccc2-c2c(C)cccc2CBr)cc1,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,O=C1CCC(=O)N1Br,,val
US05015656,COc1csc(C)c1C(O)=S.O=C1CCC(=O)N1Cl>>COc1c(Cl)sc(C)c1C(O)=S,,CC(=O)O,ClC(Cl)Cl,O,,val
US20080020942A1,CC(C)(C)OC(=O)N(CC(=O)NCCN=[N+]=[N-])N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>[N-]=[N+]=NCCNC(=O)CNN,,C1COCCO1,Cl,,,val
US20080287410A1,CC(C)(C)OC(=O)C(Br)CCBr.N[C@H]1CC[C@H](CNc2nc(NCc3ccccc3OC(F)(F)F)ncc2[N+](=O)[O-])CC1>>CC(C)(C)OC(=O)C1CCN1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20140213581A1,COC1NC(=O)c2ncc(C#N)cc2C1F.O=P(Cl)(Cl)Cl>>N#Cc1cnc2c(Cl)ncc(F)c2c1,,CC#N,,,,val
US04235620,O=C(c1ccccc1)C(Br)C(Br)c1ccccc1Cl.c1nc[nH]n1>>O=C(C=C(c1ccccc1Cl)n1cncn1)c1ccccc1,,CCCCCC,CN(C)C=O,O,[H-].[Na+],val
US20020068734A1,CCNc1cc2ncnc(N3CCN(C(=S)NCc4ccccc4)CC3)c2cc1N.S=C=S>>CCn1c(=S)[nH]c2cc3c(N4CCN(C(=S)NCc5ccccc5)CC4)ncnc3cc21,,CCO,,CCN(CC)CC,,val
US06586475B1,CN(C)CCN.COC(=O)Cc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1>>CN(C)CCNC(=O)Cc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1,,CO,,c1c[nH]cn1,,val
US20130245064A1,O=C(Cl)C(=O)Cl.O=C(O)c1[nH]c2ccc(Cl)cc2c1-c1ccccc1>>O=C(Cl)c1[nH]c2ccc(Cl)cc2c1-c1ccccc1,,ClCCl,,CN(C)C=O,,val
US20110046132A1,Nc1c(Br)cc(F)cc1Br.O=C(N=C=S)c1ccccc1>>O=C(NC(=S)Nc1c(Br)cc(F)cc1Br)c1ccccc1,CN(C)c1ccncc1,Cc1ccccc1,,,,val
US20120295924A1,Cc1scc2c1c(=O)n(C)c(=O)n2C.Nc1nc(-c2cccc(OC(F)(F)F)c2)cs1.On1nnc2ccccc21>>Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cccc(OC(F)(F)F)c4)cs3)csc2n(C)c1=O,CN(C)c1ccncc1,ClCCCl,,CCN=C=NCCCN(C)C,Cl,val
US20150250787A1,CC(=O)OCc1cc2cc3n(c2cc1S(C)(=O)=O)CCN(c1ncc(C(C)=O)c(C(F)(F)F)n1)C3C(C)C.C[Mg]Cl>>CC(C)C1c2cc3cc(CO)c(S(C)(=O)=O)cc3n2CCN1c1ncc(C(C)(C)O)c(C(F)(F)F)n1,,C1CCOC1,,O,[Cl-].[NH4+],val
US20150031540A1,COc1c(C(C)=O)nn(C)c(=O)c1-n1c(Cl)c(Cl)c2ccccc21>>COc1c(C(C)O)nn(C)c(=O)c1-n1c(Cl)c(Cl)c2ccccc21,,CCO,,[BH4-].[Na+],,val
US20110144091A1,NO.O=C1CCc2ccccc2-n2ccnc21>>ON=C1CCc2ccccc2-n2ccnc21,,CO,,Cl,CC(=O)[O-].[Na+],val
US20090018127A1,C1CCNC1.CN1C[C@H](C(=O)O)C=C2c3cccc4[nH]cc(c34)C[C@H]21>>CN1C[C@H](C(=O)N2CCCC2)C=C2c3cccc4[nH]cc(c34)C[C@H]21,,ClCCl,,CCN(CC)CC,,val
US04612314,CC(C)(C)C(=O)OC(=O)C(C)(C)C.Nc1nc2c(ncn2COC(CO)CO)c(=O)[nH]1>>CC(C)(C)C(=O)OCC(COC(=O)C(C)(C)C)OCn1cnc2c(=O)[nH]c(N)nc21,CN(C)c1ccncc1,CN(C)C=O,,,,val
US20050070592A1,CCCCCc1c(-c2ccccc2)n(Cc2ccccc2)c2ccc(-c3ccc(OC)cc3)cc12>>CCCCCc1c(-c2ccccc2)n(Cc2ccccc2)c2ccc(-c3ccc(O)cc3)cc12,,ClCCl,,BrB(Br)Br,,val
US20150018363A1,Cn1c(C2CC2)nc2ccc(-n3ccc(OCc4csc(Br)n4)cc3=O)cc21.OB(O)C1CC1>>Cn1c(C2CC2)nc2ccc(-n3ccc(OCc4csc(C5CC5)n4)cc3=O)cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20130172302A1,C1CCNCC1.COC(=O)C(Br)c1ccc(OC)cc1>>COC(=O)C(c1ccc(OC)cc1)N1CCCCC1,,C1CCOC1,,,,val
US20040127574A1,O=C(O)C(Cc1ccccc1)(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1ccc(Oc2ccccc2)cn1>>O=C(O)C(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1ccc(Oc2ccccc2)cn1,[Pd],CCO,,[H][H],,val
US20140179667A1,COC(=O)c1cc(OC(C)C)ncc1CCN1C(=O)c2ccccc2C1=O>>CC(C)Oc1cc2c(cn1)CCNC2=O,,CCO,,NN,O,val
US20160137618A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CC(C)(N=C(c2ccccc2)c2ccccc2)C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CC(C)(N)C(=O)OC(C)(C)C)C1,,CO,,[H][H],,val
US20030087874A1,COc1ccc(Cn2c(=O)ccn([C@@H]3OC([C@H](O)[C@H](NCCCNC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCc4ccccc4)C(=O)OC(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]3O[Si](C)(C)C(C)(C)C)c2=O)cc1>>COc1ccc(Cn2c(=O)ccn([C@@H]3OC([C@H](O)[C@H](NCCCNC(=O)[C@@H](N)CCC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]3O[Si](C)(C)C(C)(C)C)c2=O)cc1,[Pd],CO,,,,val
US20060264432A1,N#Cc1c(N)nc(S)c(C#N)c1-c1ccc(O)cc1.NCCBr>>N#Cc1c(N)nc(SCCN)c(C#N)c1-c1ccc(O)cc1,,CN(C)C=O,Cl,Br,O=C([O-])O.[Na+],val
US20060258662A1,Nc1cnc(Cl)cn1.O=C1CCC(=O)N1Br>>Nc1ncc(Cl)nc1Br,,ClCCl,,,,val
US20110021556A1,O=C1C=CC(=O)N1Cc1ccccc1.OB(O)c1ccc2[nH]ccc2c1>>O=C1CC(c2ccc3[nH]ccc3c2)C(=O)N1Cc1ccccc1,,C1COCCO1,O,CCN(CC)CC,,val
US20100249179A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1CCl.CCOC(=O)c1cc(=O)c2cc(-c3ccc(O)cc3)ccc2o1>>CCOC(=O)c1cc(=O)c2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)cc3)ccc2o1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06201156B1,O=C1c2ccccc2C(=O)N1O.[N]=O>>O=Cc1ccccc1C=O,,CC#N,,,,val
US04752326,Cc1nn(-c2cc(OS(C)(=O)=O)c(Cl)cc2F)c(C)c1[N+](=O)[O-]>>Cc1nn(-c2cc(O)c(Cl)cc2F)c(C)c1[N+](=O)[O-],,CCO,,Cl,[Na+].[OH-],val
US05780465,CCN(CC)S(F)(F)F.COc1ncncc1C1(O)c2ccccc2OCOc2ccccc21>>COc1ncncc1C1(F)c2ccccc2OCOc2ccccc21,,ClCCl,,,,val
US20020132810A1,CC(=O)OC(C)=O.COC(CNC(=O)C(CCC(C)(C)O)CC(O)C(Cc1cccc(F)c1)NC(=O)c1cnc2ccccc2n1)OC>>COC(CNC(=O)C(CCC(C)(C)O)CC(OC(C)=O)C(Cc1cccc(F)c1)NC(=O)c1cnc2ccccc2n1)OC,,ClCCl,c1ccncc1,CN(C)c1ccccn1,,val
US20130172302A1,O=C(O)C(c1ccc(Cl)cc1)N1CCCCC1.O[C@H]1CN2CCC1CC2>>O=C(O[C@H]1CN2CCC1CC2)C(c1ccc(Cl)cc1)N1CCCCC1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US05281614,CC(C)(C)NS(=O)(=O)c1ccccc1B(O)O.CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(Br)cc1F>>CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1F,[Pd],,,,,val
US04977162,COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1>>O=C(O)c1ccc(OCc2ccc3ccccc3n2)cc1,,CCO,,[Na+].[OH-],,val
US04735940,COC(=O)c1sccc1SCCN>>O=C1NCCSc2ccsc21,,CO,Cc1ccccc1,Cl,C[O-].[Na+],val
US20090012076A1,CN(c1ccccc1)S(=O)(=O)Cc1ccc2ccc3ncc(Cl)cc3c(=O)c2c1.NCc1ccccn1>>O=c1c2cc(CS(=O)(=O)NCc3ccccn3)ccc2ccc2ncc(Cl)cc12,,CN1CCCC1=O,,O=C([O-])O.[Na+],,val
US20100069431A1,Cn1ccnc1C(=O)Cl.Nc1cc(Br)cnc1N.O=C(O)c1cccc(O)c1>>Cn1ccnc1COc1cccc(-c2nc3ncc(Br)cc3[nH]2)c1,,CCOCC,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20150376206A1,CCC(=O)c1cccc(C(=O)OC)c1>>CCC(O)c1cccc(C(=O)OC)c1,,CO,,[BH4-].[Na+],,val
US20070293516A1,CC(C)n1nc(-c2ccc(C#N)c(F)c2)c2c(N)ncnc21.NN>>CC(C)n1nc(-c2ccc3c(N)n[nH]c3c2)c2c(N)ncnc21,,CCCCO,,O,,val
US06407129B1,CCOC(=O)[C@H](C)OC(=O)OCCl.C[C@@H](N1CCN(c2ccc(-n3cnnn3)cc2)C1=O)[C@](O)(Cn1cncn1)c1ccc(F)cc1F>>CCOC(=O)[C@H](C)OC(=O)OCN1C=N[NH+](C[C@](O)(c2ccc(F)cc2F)[C@@H](C)N2CCN(c3ccc(-n4cnnn4)cc3)C2=O)C1.[Cl-],,CC#N,,,,val
US20090105249A1,CC(C)(C)OC(=O)NC1(C(=O)O)CCCC1.O=S(=O)(c1cccc(C(F)(F)F)c1)N(C1CCNCC1)C1CC1>>NC1(C(=O)N2CCC(N(C3CC3)S(=O)(=O)c3cccc(C(F)(F)F)c3)CC2)CCCC1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20150376136A1,CCOC(=O)c1cnn(CC)c1>>CCn1cc(C(=O)O)cn1,,CO,,Cl,[Na+].[OH-],val
US04241058,CCOC(=O)C(C)=CC1CCC(C(C)(C)C)CC1>>CC(=CC1CCC(C(C)(C)C)CC1)CO,,Cc1ccccc1,,[Na+].[OH-],,val
US20100075948A1,CC(C)(C)CC=O.N#CCc1ccc(Cl)cc1>>CC(C)(C)C/C=C(\C#N)c1ccc(Cl)cc1,,CO,,C[O-].[Na+],,val
US20090005356A1,CN(C)C(=O)c1cncc(-c2cnc3c(c(-c4ccccc4F)cn3COCC[Si](C)(C)C)c2Cl)c1>>CN(C)C(=O)c1cncc(-c2cnc3[nH]cc(-c4ccccc4F)c3c2Cl)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030045705A1,Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O.O=C1c2ccccc2C(=O)N1O>>Cc1cn([C@H]2C[C@H](O)[C@@H](CON3C(=O)c4ccccc4C3=O)O2)c(=O)[nH]c1=O,,CN(C)C=O,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04040907,C1CCOC1.N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O.O=C1COCC(=O)O1>>COC(=O)[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)NC(=O)COCC(=O)O,,C1CCOC1,ClC(Cl)Cl,CCN(CC)CC,Cl,val
US20100087427A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2N)C(C)C)ccc1OC.O=C(Cl)CCc1ccccc1>>COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2NC(=O)CCc2ccccc2)C(C)C)ccc1OC,,O,,CC#N,CC#N,val
US20160145245A1,BrCCOC1CCCCO1.CC(C)(C)OC(=O)N[C@H](C(=O)O)c1ccc(O)cc1>>CC(C)(C)OC(=O)N[C@H](C(=O)O)c1ccc(OCCOC2CCCCO2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20150182537A1,Cn1nccc1Nc1nccc(-c2cc(F)nc(F)c2)n1.NN>>Cn1nccc1Nc1nccc(-c2cc(F)nc(NN)c2)n1,,CCO,,,,val
US04402961,c1ccc(CCc2ccnc3ccccc23)nc1>>c1ccc2c(CCC3CCCCN3)ccnc2c1,O=[Pt],CCO,,CC(=O)O,,val
US20120053173A1,Br[Mg]C1CCCCC1.COc1cccc(-n2cc(C=O)c(C)n2)c1>>COc1cccc(-n2cc(C(O)C3CCCCC3)c(C)n2)c1,,C1CCOC1,,,,val
US07160901B2,CCOC(=O)CN(c1ccc([N+](=O)[O-])cc1)S(C)(=O)=O>>CS(=O)(=O)N(CC(=O)O)c1ccc([N+](=O)[O-])cc1,,CCO,,Cl,[Na+].[OH-],val
US20150141433A1,COC(=O)c1cnc(CN)cn1.O=S(=O)(Cl)c1ccc(F)c(Cl)c1>>COC(=O)c1cnc(CNS(=O)(=O)c2ccc(F)c(Cl)c2)cn1,,ClCCl,,CCN(CC)CC,Cl,val
US05843983,CCOC(=O)N1C[C@H](O)C[C@H]1CCCl.COc1cc(CCc2cc(F)ccc2O)ccc1F>>CCOC(=O)N1C[C@H](O)C[C@H]1CCOc1ccc(F)cc1CCc1ccc(F)c(OC)c1,,CC(=O)N(C)C,,CC(C)(C)[O-].[K+],,val
US04257802,CN(C(=O)Cl)S(=O)(=O)c1cc(Cl)ccc1Cl.CNc1nc(C)cc(OC)n1>>COc1cc(C)nc(N(C)C(=O)N(C)S(=O)(=O)c2cc(Cl)ccc2Cl)n1,,C1CCOC1,,CCN(CC)CC,,val
US20130059883A1,C1CCSC1.CCOC(=O)CBr>>CCOC(=O)C[S+]1CCCC1.[Br-],,CC(C)=O,,,,val
US20130274260A1,NC1CCCCC1.O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1cccc(CCl)c1>>O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1cccc(CNC2CCCCC2)c1,,C1CCOC1,,[I-].[Na+],,val
US20060205802A1,CC(=O)Nc1ccc2c(c1)nc(C(C)(C)C)n2CC1CCCCC1.CI>>CC(=O)N(C)c1ccc2c(c1)nc(C(C)(C)C)n2CC1CCCCC1,,C1CCOC1,,[H-].[Na+],,val
US20150239884A1,CS(=O)(=O)c1ncc2ccnc(Cl)c2n1.Cc1cc(-c2cnn(C)c2)ccc1NC=O>>Cc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(Cl)c2n1,,C1CCOC1,,[H-].[Na+],,val
US20030130213A1,COC(=O)c1nc(Cl)cn([C@@H]2O[C@@H](CO)[C@@H](O)[C@H]2O)c1=O.N>>NC(=O)c1nc(Cl)cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1=O,,CO,,,,val
US20130071327A1,CCOC(=O)/C(=C/C[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)CCCF>>N[C@@H](C/C=C(\CCCF)C(=O)O)C(=O)O,,O,,Cl,,val
US03931199,O=C(O)c1ccc(Oc2ncccc2C(=O)O)cc1>>O=C(O)c1ccc2oc3ncccc3c(=O)c2c1,,O,,O=S(=O)(O)O,,val
US20140107194A1,NCCO.O=C(O)c1ccc(C[C@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@@H]2O)cc1>>O=C(NCCO)c1ccc(C[C@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@@H]2O)cc1,,ClCCl,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US20050148640A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1nonc1N>>CCOC(=O)c1nonc1NC(=O)OC(C)(C)C,CN(C)c1ccncc1,C1CCOC1,,,,val
US20150038510A1,Cc1cc(C)c(Br)c([N+](=O)[O-])c1>>Cc1cc(C)c(Br)c(N)c1,[Fe],CCOC(C)=O,,CCO,Cl,val
US20100298140A1,CC(O)c1cnc(-c2ccc(Cl)cc2)s1.CC12CCC(O1)C1C(Cl)=CC(=O)C12>>CC12CCC(O1)C1C(OCc3cnc(-c4ccc(Cl)cc4)s3)=CC(=O)C12,,C1CCOC1,,[H-].[Na+],,val
US20160228450A1,CC(C)(C)OC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(-c2ncc(Br)cn2)cc1)NC(=O)c1ccc(C(C)(C)C)s1>>CC(C)(C)c1ccc(C(=O)N[C@@H](Cc2ccc(-c3ncc(Br)cn3)cc2)C(=O)N2CCC[C@H]2C(=O)O)s1,,ClCCl,,,,val
US20020099047A1,Cl.Clc1ccc(CCN2CC[C@@H](N3c4ccccc4COc4ccccc43)C2)cc1>>Cl.Clc1ccc(CCN2CC[C@@H](N3c4ccccc4COc4ccccc43)C2)cc1,,ClCCl,,CCOCC,,val
US05994342,O=C(CCl)NCC1CN2C(=O)CC2O1.O=C[O-]>>O=COCC(=O)NCC1CN2C(=O)CC2O1,,CS(C)=O,,O,,val
US20140179680A1,C[C@@H]1CC[C@@H](CNc2c(NC(=O)OC(C)(C)C)cc(Cl)nc2Cl)CC1>>C[C@@H]1CC[C@@H](CNc2c(N)cc(Cl)nc2Cl)CC1,,C1COCCO1,Cl,,,val
US20100331293A1,Cc1c(-c2ccccn2)nc2cc(F)ccc2c1Cl.O>>Cc1c(-c2ccccn2)nc2cc(F)ccc2c1O,,CN1CCCC1=O,,CCOC(C)=O,,val
US20090137499A1,CCOC(=O)c1ccc(C=O)c(O)c1.CCOc1ccc(Br)cc1>>CCOC(=O)c1ccc(C(O)c2ccc(OCC)cc2)c(O)c1,,C1CCOC1,,Cl,[Mg],val
US20160016947A1,C=Cc1nn(C)c2ccccc12.CCOC(=O)C=[N+]=[N-]>>CCOC(=O)C1CC1c1nn(C)c2ccccc12,,Cc1ccccc1,,,,val
US20090239865A1,CCC=O.Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)ccc2Br)n1>>CCC(O)c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20120114765A1,Clc1cncc(Cl)c1Cl.OO>>[O-][n+]1cc(Cl)c(Cl)c(Cl)c1,,ClCCl,,,,val
US04902335,Nc1cc2c(cc1F)OCC(=O)N2Cc1ccccn1.O=C1OC(=O)C2=C1CCCC2>>O=C1COc2cc(F)c(N3C(=O)C4=C(CCCC4)C3=O)cc2N1Cc1ccccn1,,CC(=O)O,,,,val
US20150299143A1,CCc1ccc(C(N)C#N)cc1.COc1ccc(C(=O)NCCn2cc(C(=O)O)nn2)c(OC)c1OC>>CCc1ccc(C(C#N)NC(=O)c2cn(CCNC(=O)c3ccc(OC)c(OC)c3OC)nn2)cc1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150361101A1,C=C[Sn](CCCC)(CCCC)CCCC.Fc1cccc2[nH]c(-c3cc(Cl)nnc3Cl)cc12>>C=Cc1nnc(Cl)cc1-c1cc2c(F)cccc2[nH]1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,[Cl-].[Li+],,val
US04678781,CN(C)CCCl.CSc1ccncc1.Cl>>CSc1cc[n+](CCN(C)C)cc1.[Cl-],,CCO,,,,val
US20030166639A1,CCCc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccnc(C)c3)c2)cc1C(F)(F)F>>CCc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3ccnc(C)c3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US06660724B1,CC(C)OP([O-])OC(C)C.CNCc1cccnc1.COc1cc(C=O)cc(C)c1O>>COc1cc(-c2ncccc2CN(C)CP(=O)(OC(C)C)OC(C)C)cc(C)c1O,Cc1ccc(S(=O)(=O)O)cc1,,,Cc1ccccc1,,val
US04448962,C1CNCCN1.C=CCn1cc(C(=O)O)c(=O)c2cc(F)c(Cl)cc21>>C=CCn1c(N2CCNCC2)c(C(=O)O)c(=O)c2cc(F)ccc21.Cl,,c1ccncc1,,,,val
US05530019,CCCCC(=O)c1ccc(CC(C)C)cc1>>CCCCC(O)c1ccc(CC(C)C)cc1,,CC(C)O,,Cl,[BH4-].[Na+],val
US04166115,CON=C(C(=O)OC)c1ccc(O)c([N+](=O)[O-])c1>>CON=C(C(=O)O)c1ccc(O)c([N+](=O)[O-])c1,,CO,,[Na+].[OH-],,val
US20100152207A1,CN(C(=O)c1ccc(Cl)c(B2OC(C)(C)C(C)(C)O2)c1)c1ccccc1O.Cc1cc(C#N)ncc1Br>>Cc1cc(C#N)ncc1-c1cc(C(=O)N(C)c2ccccc2O)ccc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US05182272,CCC(=O)CCC(=O)OC.OCCO>>CCC1(CCC(=O)OC)OCCO1,,Cc1ccccc1,,,,val
US20140235671A1,CCOC(=O)CCCCCCN(c1ccccn1)c1cc(OS(=O)(=O)C(F)(F)F)ccn1.Cc1ccc(B(O)O)cc1>>CCOC(=O)CCCCCCN(c1ccccn1)c1cc(-c2ccc(C)cc2)ccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O,O=C([O-])[O-].[K+].[K+],val
US20130336920A1,CCN(CC)c1ccc(NC(=O)c2cccc(C(=O)OC(C)(C)C)c2)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1>>CCN(CC)c1ccc(NC(=O)c2cccc(C(=O)O)c2)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1,,C1COCCO1,,Cl,,val
US05723462,O=C(O)c1c[nH]c2c1C(=O)CCC2.O=C1CCC(=O)N1Br>>O=C(O)c1c(Br)[nH]c2c1C(=O)CCC2,,CN(C)C=O,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20050176717A1,CC(C=O)NC(=O)OC(C)(C)C.NC(c1nc2ccccc2nc1Cc1ccccc1)C1CC1.c1ccc(Cc2nc3ccccc3nc2CNC2CC2)cc1>>CC(C)(C)OC(=O)NCCCNC(c1nc2ccccc2nc1Cc1ccccc1)C1CC1,,CC(=O)O,CO,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090215776A1,CC(C)(C)OC(=O)N[C@@H]1CCNC1.O=Cc1ccc(-c2cncc(-c3cc(NC4CC4)nc(-c4ccccn4)c3)c2)cc1>>CC(C)(C)OC(=O)N[C@@H]1CCN(Cc2ccc(-c3cncc(-c4cc(NC5CC5)nc(-c5ccccn5)c4)c3)cc2)C1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120202777A1,Brc1ccc(CCI)cn1.CCOC(=O)CS(C)(=O)=O>>CCOC(=O)C(CCc1ccc(Br)nc1)S(C)(=O)=O,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20090198070A1,CC(C)[C@H](N)CO.O=C(O)CCc1ccccc1>>CC(C)[C@H]1COC(CCc2ccccc2)=N1,,Clc1ccccc1,,,,val
US20110118245A1,CN1CCNCC1.COc1cc2c(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C)on4)c3)ncnc2cc1OC[C@H]1CO1>>COc1cc2c(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C)on4)c3)ncnc2cc1OC[C@H](O)CN1CCN(C)CC1,,CN(C)C=O,,,,val
US20160194304A1,C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2c(cc1-c1cc(C(=O)N(C)c3ccc(OCc4ccccc4)cc3)c3n1CCCC3)CCN(C(=O)N(C)c1ccccc1)C2>>C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2c(cc1-c1cc(C(=O)N(C)c3ccc(O)cc3)c3n1CCCC3)CCN(C(=O)N(C)c1ccccc1)C2,[Pd],CCO,,,,val
US20100298340A1,COC(=O)c1ccc(-c2sc(NC(=N)N)nc2C)cc1>>Cc1nc(NC(=N)N)sc1-c1ccc(C(=O)O)cc1,,C1CCOC1,,[Li+].[OH-],,val
US20080146607A1,CCCC1(C(O)c2ccc(Cl)c(Cl)n2)CCCN1C(=O)OC(C)(C)C>>CCCC1(C(=O)c2ccc(Cl)c(Cl)n2)CCCN1C(=O)OC(C)(C)C,,ClCCl,,,,val
US20120041004A1,CC(C)(C)COc1c(Cl)cc(-c2csc(NC(=O)CBr)n2)cc1Cl.Cc1c[nH]c2c(=O)n(C)c(=O)n(C)c12>>Cn1c(=O)c2c(ccn2CC(=O)Nc2nc(-c3cc(Cl)c(OCC(C)(C)C)c(Cl)c3)cs2)n(C)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20130274260A1,COC(=O)c1ccc(Cc2cccc(F)c2)cc1>>O=C(O)c1ccc(Cc2cccc(F)c2)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20150307449A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCc1c[nH]c(-c2ccccc2F)c1>>CN(Cc1c[nH]c(-c2ccccc2F)c1)C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,[Cl-].[NH4+],val
US20090004185A1,CNC.O=C(Nc1ccc(F)cc1)Nc1ccc(CNc2nc(Cl)nc3ccccc23)cc1>>CN(C)c1nc(NCc2ccc(NC(=O)Nc3ccc(F)cc3)cc2)c2ccccc2n1,,C1CCOC1,CC(C)O,Cl,,val
US06960586B2,CC(C)(C)[Si](C)(C)Oc1ccc2cc(Br)ccc2c1.CC(C)C(=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CC(C)C(O)(c1ccc2cc(O[Si](C)(C)C(C)(C)C)ccc2c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,,C1CCOC1,CCCCCC,O,[Li]CCCC,val
US05719151,C=CC(=O)Cl.NC(=O)c1cccc(N)c1>>C=CC(=O)Nc1cccc(C(N)=O)c1,,CC(C)=O,,,,val
US20100144745A1,CCOC(=O)C1(C)CCN(C(=O)OC(C)(C)C)CCC1=O>>CC1CCN(C(=O)OC(C)(C)C)CCC1=O,,C1COCCO1,,[K+].[OH-],,val
US04113940,CC1C=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(NC(=O)Cc3cccc(Cl)c3)[C@H]2S1>>CC1C=C(C(=O)O)N2C(=O)C(NC(=O)Cc3cccc(Cl)c3)[C@H]2S1,[Zn],CN(C)C=O,,CC(=O)O,,val
US20120041004A1,Cc1c[nH]c2c(=O)n(C)c(=O)n(C)c12.O=C(CBr)Nc1nc(-c2cc(F)c(OC(F)F)c(F)c2)cs1>>Cn1c(=O)c2c(ccn2CC(=O)Nc2nc(-c3cc(F)c(OC(F)F)c(F)c3)cs2)n(C)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20150148311A1,O=C(Cl)C1(OCc2cc(Cl)ccc2Cl)CC1.c1cnc2c(c1)CCCN2>>O=C(N1CCCc2cccnc21)C1(OCc2cc(Cl)ccc2Cl)CC1,,ClCCl,,CCN(CC)CC,,val
US04238487,CN(C)Cc1ccc2cc(CSCCN)oc2c1.CSC(=C[N+](=O)[O-])SC>>CSC(=C[N+](=O)[O-])NCCSCc1cc2ccc(CN(C)C)cc2o1,,CC#N,,,,val
US06399629B1,Cc1ccc(S(=O)(=O)O[C@H]2C[C@@H](C(=O)Nc3cnc4ccccc4c3)N(C(=O)OC(C)(C)C)C2)cc1.[N-]=[N+]=[N-]>>CC(C)(C)OC(=O)N1C[C@H](N=[N+]=[N-])C[C@H]1C(=O)O,,CN(C)C=O,,O,,val
US20100310512A1,COC(=O)NC(C(=O)N1CCCC1c1nc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c[nH]1)C(C)C.COC(=O)NC(C(=O)N1CN(C(=O)OC(C)(C)C)CC1c1nc(-c2ccc(Br)cc2)c[nH]1)C(C)C>>COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc(-c3ccc(-c4cnc(C5CN(C(=O)OC(C)(C)C)CN5C(=O)C(NC(=O)OC)C(C)C)[nH]4)cc3)cc2)[nH]1)C(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US06005118,Br.CCc1nn(C2CCCCC2)c2cc(F)ccc12>>Br.CCc1nn(C2CCCCC2)c2cc(F)ccc12,,CC(=O)O,Cc1ccccc1,,,val
US20130090340A1,CC(C)(CNC(=O)Oc1ccc([N+](=O)[O-])cc1)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.NC(=O)c1c(-c2cccc(F)c2)c(Cl)n2c1CNCC2>>CC(C)(CNC(=O)N1CCn2c(Cl)c(-c3cccc(F)c3)c(C(N)=O)c2C1)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,CC#N,,[Na+].[OH-],,val
US20130331411A1,CCCC(=O)Nc1cccc([N+](=O)[O-])c1>>CCCC(=O)Nc1cccc(N)c1,[Pd],CO,,[H][H],,val
US20160031866A1,CC(C)(C)OC(=O)c1ccnc(Cl)c1.CC(C)C[Mg]Cl>>CC(C)Cc1cc(C(=O)OC(C)(C)C)ccn1,,C1CCOC1,,CN1CCCC1=O,,val
US20030191316A1,CCOC(=O)C=CC1CCN(C(=O)OC(C)(C)C)CC1>>CCOC(=O)CCC1CCN(C(=O)OC(C)(C)C)CC1,[Pd],CCO,,[H][H],,val
US20070078121A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)c1cc(N)n(-c2ccc3c(c2)CCNC3)n1>>CC(C)(C)OC(=O)N1CCc2cc(-n3nc(C(C)(C)C)cc3N)ccc2C1,,ClCCl,,,,val
US20060252797A1,Cc1cccc(C2(N(C(=O)C(F)(F)F)c3ccccc3)CCN(Cc3ccccc3)CC2)n1.O=C(O)C(=O)O>>Cc1cccc(C2(N(C(=O)C(F)(F)F)c3ccccc3)CCN(Cc3ccccc3)CC2)n1.O=C(O)C(=O)O,,CC(C)O,CCOC(C)=O,,,val
US06255306B1,Cc1cc2c(N3CCN(C)CC3)cccc2[nH]1.O=C(Cl)OCC(Cl)(Cl)Cl>>Cc1cc2c(N3CCN(C(=O)OCC(Cl)(Cl)Cl)CC3)cccc2[nH]1,,ClCCl,,O=C([O-])O.[Na+],,val
US20020072516A1,C=CCBr.CCc1cc(C[C@H](NC(C)=O)C(=O)O)ccc1N>>C=CCOC(=O)C(Cc1ccc(N)c(CC)c1)NC(C)=O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160264520A1,NCCc1ccc([N+](=O)[O-])cc1.O=Cc1ccc([N+](=O)[O-])cc1>>O=[N+]([O-])c1ccc(C=NCCc2ccc([N+](=O)[O-])cc2)cc1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20050203091A1,COC(=O)C(c1cnc(C(=O)c2ccccc2Cl)c(Cl)n1)c1ccccc1F.NN>>Fc1ccccc1Cc1cnc2c(-c3ccccc3Cl)n[nH]c2n1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20060235033A1,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccc([C@@H](C)N)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)N[C@H](C)c4ccc(C)cc4)cc3)c2cc1OC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20050014792A1,CN1CCNCC1.Cc1ccccc1-c1cc(Cl)ncc1C#N>>Cc1ccccc1-c1cc(N2CCN(C)CC2)ncc1C#N,,Cc1ccccc1,,,,val
US20120142735A1,Cc1ccc(F)c2cc[nH]c12.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1ccc(F)c2c(C(=O)C(F)(F)F)c[nH]c12,,CN(C)C=O,,,,val
US05286721,C=CCOC(=O)N(C)CC(CN(C)C(=O)OCC=C)C(C)O[Si](C)(C)C(C)(C)C.O>>C=CCOC(=O)N(C)CC(CN(C)C(=O)OCC=C)C(C)(O)O,,CCOC(C)=O,,Cl,,val
US05892133,CC1CCC2C(C)CC(=O)OC2C1>>CC1CCC(C(C)CCO)C(O)C1,,CCOCC,CCOCC,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20110160243A1,CC(C)(C)OC(=O)CC1CCn2c1cc1cc(O)ccc12.CC(C)Oc1ccc(CCl)cc1C(F)(F)F>>CC(C)Oc1ccc(COc2ccc3c(c2)cc2n3CCC2CC(=O)OC(C)(C)C)cc1C(F)(F)F,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050054662A1,COc1cc(O)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1.OC1CCSC1>>COc1cc(OC2CCSC2)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1,,ClCCl,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140228367A1,CCN(CC(=O)O)c1ccc(F)cc1>>O=C(O)CNc1ccc(F)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20110105462A1,CCCN.Cc1ccc(S(=O)(=O)OCC2COc3ccc(F)c(F)c3O2)cc1>>CCCNCC1COc2ccc(F)c(F)c2O1,,CC#N,,,,val
US20120202852A1,CC(C)(C)[S@@](N)=O.O=Cc1ccc(Br)cc1>>CC(C)(C)S(=O)/N=C/c1ccc(Br)cc1,[Cu],ClCCl,,,,val
US20100158863A1,CNC(=O)c1nc(C)n(-c2ccc([N+](=O)[O-])cc2)n1>>CNC(=O)c1nc(C)n(-c2ccc(N)cc2)n1,[Pd],CO,,[H][H],,val
US06579868B1,C=CCO.Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCC3)nc21>>Cn1c(-c2cccc(F)c2)nc2c(O)nc(C#CC3(O)CCCC3)nc21,,C1CCOC1,,[Na+].[OH-],,val
US20140128392A1,Nc1ccc(C(=O)O)cc1N.O=C(C(=O)c1ccco1)c1ccccc1>>O=C(O)c1ccc2nc(-c3ccco3)c(-c3ccccc3)nc2c1,,CC(=O)O,,,,val
US20070299051A1,CN1CCNCC1.COC(=O)c1cc(C)c2c(c1)S(=O)(=O)Cc1cc(NCCCl)cc(Cl)c1O2>>COC(=O)c1cc(C)c2c(c1)S(=O)(=O)Cc1cc(NCCN3CCN(C)CC3)cc(Cl)c1O2,,CN(C)C=O,,O,,val
US20090264445A1,CC(C)C[C@@H](C(=O)Nc1ccn(C[C@@H]2COC(C)(C)O2)n1)N1CC(Oc2cc(F)ccc2F)=CC1=O>>CC(C)C[C@@H](C(=O)Nc1ccn(C[C@@H](O)CO)n1)N1CC(Oc2cc(F)ccc2F)=CC1=O,,CCOC(C)=O,CO,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20040014971A1,O=C(Nc1ccc(C2CCN(Cc3ccccc3)CC2)cc1)c1ccccc1-c1ccccc1>>O=C(Nc1ccc(C2CCNCC2)cc1)c1ccccc1-c1ccccc1,[Pd],CO,,[H][H],,val
US20090239848A1,CC(=O)NNC(=O)c1ccc([N+](=O)[O-])cc1>>Cc1nnc(-c2ccc([N+](=O)[O-])cc2)o1,,O=P(Cl)(Cl)Cl,,,,val
US20050165049A1,O=Cc1ccccc1-c1ccc(C(=O)Nc2ccc3cccnc3c2)cc1>>O=C(Nc1ccc2cccnc2c1)c1ccc(-c2ccccc2CO)cc1,,CCOC(C)=O,CO,[BH4-].[Na+],,val
US04025637,CC(C#N)c1ccc(O)c(N)c1.O=C(Cl)Cc1ccccc1>>CC(C#N)c1ccc(O)c(NC(=O)Cc2ccccc2)c1,,c1ccncc1,,,,val
US20080161289A1,CN.O=C(c1ccc(N2CCC(c3nc4c(s3)CCN(C3CCC3)CC4)CC2)cn1)n1ccnc1>>CNC(=O)c1ccc(N2CCC(c3nc4c(s3)CCN(C3CCC3)CC4)CC2)cn1,,ClCCl,,C1CCOC1,,val
US20100063119A1,CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1O.II>>CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)cc(I)c1O,,c1ccncc1,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20120252779A1,O=[N+]([O-])c1c[nH]cn1.OCCBr>>Nc1cn(CCO)cn1,,CN(C)C=O,,,,val
US20060069145A1,CCN1C(=O)C(C)(C)c2cc3c(cc21)nc(C(=O)C=C(SC)SC)n3C1CCCCO1.NN>>CCN1C(=O)C(C)(C)c2cc3[nH]c(-c4cc(SC)[nH]n4)nc3cc21,,CC#N,,O,,val
US05498774,COC(=O)c1cccn2cc(C)nc12>>Cc1cn2cccc(C(=O)O)c2n1,,CCO,O,[Na+].[OH-],,val
US03993660,O=C1NC(=O)c2ccccc21.O=CNc1cccc(-n2c(CO)nnc2Cc2ccccc2)c1C(=O)c1ccccc1Cl>>O=CNc1cccc(-n2c(Cc3ccccc3)nnc2CN2C(=O)c3ccccc3C2=O)c1C(=O)c1ccccc1Cl,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160251339A1,COc1c(N2CCN(C(=O)C(Cl)(Cl)Cl)CC2)cc(S(=O)(=O)Cl)c2ccccc12.O=Cc1c[nH]c2cc(Cl)ccc12>>COc1c(N2CCN(C(=O)C(Cl)(Cl)Cl)CC2)cc(S(=O)(=O)n2cc(C=O)c3ccc(Cl)cc32)c2ccccc12,,C1CCOC1,,[H-].[Na+],,val
US20130079377A1,CCOC(=O)C(C)c1ccc(CNS(=O)(=O)NC(=O)OC(C)(C)C)cc1>>CC(C(=O)O)c1ccc(CNS(=O)(=O)NC(=O)OC(C)(C)C)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20100305102A1,CN1C[C@@H](N)CCC1=O.Clc1nc(Cl)c2c(n1)CCS2>>CN1C[C@@H](Nc2nc(Cl)nc3c2SCC3)CCC1=O,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20120276018A1,O=C(CBr)c1ccccc1F.O=C(OC(c1cccc(F)c1)c1cccc(F)c1)C1CN2CCC1CC2>>O=C(C[N+]12CCC(CC1)C(C(=O)OC(c1cccc(F)c1)c1cccc(F)c1)C2)c1ccccc1F.[Br-],,CC#N,,,,val
US20130005707A1,Cc1cc([N+](=O)[O-])cc2c1C(C)(C)C(=O)N2C(=O)OC(C)(C)C>>Cc1cc(N)cc2c1C(C)(C)C(=O)N2C(=O)OC(C)(C)C,[Pd],CCOC(C)=O,,,,val
US20050107355A1,O=C(Cl)C(=O)Cl.O=C([O-])CC(=O)OCc1ccccc1>>O=C(Cl)CC(=O)OCc1ccccc1,CN(C)C=O,ClCCl,,,,val
US20140080808A1,CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(C3(c4ccc(B5OC(C)(C)C(C)(C)O5)cc4)CC3)n2CCS1.FC(F)(F)c1ccc(Cl)nc1>>CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(C3(c4ccc(-c5ccc(C(F)(F)F)cn5)cc4)CC3)n2CCS1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20160235716A1,C[C@H](N)C1CCC1.O=Cc1ccccc1>>C[C@@H](NCc1ccccc1)C1CCC1,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090062268A1,C=O.NC(=O)c1cccc2[nH]c(C3CCC4(CC4)N3)nc12>>CN1C(c2nc3c(C(N)=O)cccc3[nH]2)CCC12CC2,,CO,,[BH3-]C#N.[Na+],,val
US20160106754A1,CC(=O)NN1C(=O)C2=C(CC1c1ccccn1)Nc1ccc(OC(F)(F)F)cc1S2>>NN1C(=O)C2=C(CC1c1ccccn1)Nc1ccc(OC(F)(F)F)cc1S2,,CO,,Cl,,val
US04357340,Cc1ccc(Cn2ccnc2)cc1C.O=C(O)CCC(=O)O>>Cc1ccc(Cn2ccnc2)cc1C.O=C(O)CCC(=O)O,,CCO,,,,val
US04783458,C1CCNCC1.C=O.CC(C)(C)c1ccc2c(c1)C(=O)CCC2>>CC(C)(C)c1ccc2c(c1)C(=O)C(CN1CCCCC1)CC2,Cl,CCO,,,,val
US20150218124A1,C1COCCN1.COc1cc(C#N)c(CBr)c(C#N)c1O>>COc1cc(C#N)c(CN2CCOCC2)c(C#N)c1O,,CN(C)C=O,,[H-].[Na+],,val
US20100081690A1,CC(C)(C)OC(=O)N1CCC[C@H](C(N)=O)C1.Cl>>Cl.NC(=O)[C@H]1CCCNC1,,ClCCl,,,,val
US20090170849A1,COC(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1>>COC(=O)c1cc(CO)cc([N+](=O)[O-])c1,,C1CCOC1,,CSC,,val
US20060276464A1,COC(=O)C1CCCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(C)C)C1>>CC(C)c1ccc(S(=O)(=O)c2ccccc2)cc1S(=O)(=O)NC1CCCC(C(=O)O)C1,,C1CCOC1,,[Na+].[OH-],,val
US20120252815A1,CC(=O)OCCCCBr.CC1(C)CCC(C)(C)c2cc(-c3csc(C4CCCNC4)n3)ccc21>>CC1(C)CCC(C)(C)c2cc(-c3csc(C4CCCN(CCCCO)C4)n3)ccc21,,CO,,Br,[Na+].[OH-],val
US20130345181A1,CCOC(OCC)c1cc2cnc(Br)cc2n1S(C)(=O)=O>>CCOC(OCC)c1cc2cnc(Br)cc2[nH]1,,CO,,O,[Na+].[OH-],val
US05591762,CCCc1nc2c(C)cc(-c3cn(CC4CCCC4)cn3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCc1nc2c(C)cc(-c3cn(CC4CCCC4)cn3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160046635A1,C=CCNc1nc(NCC=C)c2nc(Cl)nc(NCC=C)c2n1.Fc1ccc(CN2CCNCC2)cc1>>C=CCNc1nc(NCC=C)c2nc(N3CCN(Cc4ccc(F)cc4)CC3)nc(NCC=C)c2n1,,CCCCO,,O=C([O-])O.[Na+],,val
US05236952,BrB(Br)Br.COc1cc(-c2cc(O)n(C)n2)cc([N+](=O)[O-])c1OC>>Br.Cn1nc(-c2cc(O)c(O)c([N+](=O)[O-])c2)cc1O,,ClCCl,,CCO,,val
US20100048940A1,CC(C)=O.OCC(O)CO>>CC(C)=O.OCC(O)CO,[Pd],,,,,val
US20100331315A1,C[C@H](Nc1cncc(-c2csc(C=O)c2)n1)C1CC1.O=C1CSC(=O)N1>>C[C@H](Nc1cncc(-c2csc(/C=C3\SC(=O)NC3=O)c2)n1)C1CC1,,CCO,,C1CCNCC1,,val
US20080153837A1,N#Cc1ccc2[nH]c(-c3cccc4c3-c3ccccc3C4=NO)nc2c1>>N#Cc1ccc2[nH]c(-c3cccc4c3-c3ccccc3C4N)nc2c1,[Zn],CCO,O,CC(=O)O,,val
US20130281657A1,CC(C)C(Nc1ncc(C=O)s1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)OC(C)(C)C>>CC(C)C(Nc1ncc(C=O)s1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US07629358B2,COC(=O)Cc1cccc(CC(C)(C)NC[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(OCc3ccccc3)c(CO)c2)c1>>CC(C)(Cc1cccc(CC(=O)O)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OCc2ccccc2)c(CO)c1,,C1CCOC1,CO,[Li+].[OH-],,val
US20150166558A1,CC(C)(C)OC(=O)N[C@@H](CO)c1ccc(O)cc1.CCOC(=O)CBr>>CCOC(=O)COc1ccc([C@H](CO)NC(=O)OC(C)(C)C)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040235867A1,CCN(CC)C(=O)CN1CCc2c1ccnc2Cl>>CCN(CC)C(=O)Cn1ccc2c(Cl)nccc21,O=[Mn]=O,C1CCOC1,,,,val
US04060603,CC[C@@H]1CCN[C@H]1C(N)=O.O>>CC[C@@H]1CCN[C@H]1C(N)=O.O,,O,,Cl,,val
US20030013704A1,NCCOCCO.O=Cc1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1>>O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(CNCCOCCO)ccc1Cl,,ClCCCl,ClCCl,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120028973A1,COC(=O)/C=C/c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1>>OC/C=C/c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1,,Cc1ccccc1,ClCCl,CC(C)C[AlH]CC(C)C,,val
US20110053909A1,CCc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(CCOCCC(=O)O)c4Cl)CC3)C2)cs1.COC(CNC1CCCC1)OC>>CCc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(CCOCCC(=O)N(CC(OC)OC)C5CCCC5)c4Cl)CC3)C2)cs1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140128372A1,CC(C)OCC(O)CN.O=C(Cl)OCc1ccccc1>>CC(C)OCC(O)CNC(=O)OCc1ccccc1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20100016401A1,CC(=O)CCl.CCOC(=O)c1[nH]c(=S)[nH]c1C>>CCOC(=O)c1nc2scc(C)n2c1C,,CC#N,CCO,O=P(Cl)(Cl)Cl,,val
US04748253,CCC(=O)c1ccc(N)cc1.O=C1OC(=O)c2ccccc21>>CCC(=O)c1ccc(N2C(=O)c3ccccc3C2=O)cc1,,CC(=O)O,,,,val
US05639770,CCOc1ccc(-c2nc(-c3cccc(C4CO4)n3)cs2)cc1OCC.CNC>>CCOc1ccc(-c2nc(-c3cccc(C(O)CN(C)C)n3)cs2)cc1OCC,,CO,,,,val
US07855292B2,C[C@@H](NC(=O)OC(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)c1ccc(Cl)cc1.Cl>>C[C@@H](N)[C@@H](O)c1ccc(Cl)cc1.Cl,,CO,,,,val
US05041679,CC(=O)CC(O)CCSc1cccc(C(F)(F)F)c1>>CC(=O)C=CCCSc1cccc(C(F)(F)F)c1,,Cc1ccccc1,,O=C(O)C(=O)O,,val
US20090137581A1,CC(=O)NNC(=O)c1nc2c(Cl)cccc2cc1[C@H](C)N1C(=O)c2ccccc2C1=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>Cc1nnc(-c2nc3c(Cl)cccc3cc2[C@H](C)N2C(=O)c3ccccc3C2=O)s1,,C1CCOC1,Cc1ccccc1,,,val
US20070254877A1,CCOC(=O)N1CCC(O)(c2ccc(C(F)(F)F)cc2)CC1>>OC1(c2ccc(C(F)(F)F)cc2)CCNCC1,,CCO,O,[K+].[OH-],,val
US05834463,O=C1C2CCCC2=Nc2cc([N+](=O)[O-])ccc2N1Cc1ccccc1>>O=C1[C@H]2CCC[C@H]2Nc2cc([N+](=O)[O-])ccc2N1Cc1ccccc1,,CCOCC,,,,val
US20120010191A1,COCc1cc([N+](=O)[O-])nn1C>>COCc1cc(N)nn1C,[Pd],CCO,,,,val
US04371720,O=C1CCCCC2OC12>>O=C1CCCCC(O)C1,,C1CCOC1,,,,val
US20030036652A1,Nc1ccc(S(=O)(=O)C(F)(F)F)cc1[N+](=O)[O-]>>Nc1ccc(S(=O)(=O)C(F)(F)F)cc1N,[Pd],CCO,,,,val
US20070010558A1,NC(=O)c1ccc(OC2CCC(=O)CC2)cc1.NCCCc1ccccc1>>NC(=O)c1ccc(OC2CCC(NCCCc3ccccc3)CC2)cc1,,ClCCl,,CC(=O)O,,val
US20150291593A1,CCOP(=O)(OCC)C(NC(=O)OCc1ccccc1)C(=O)OC.O=Cc1ccc[nH]1>>COC(=O)c1cc2cccn2c(=O)[nH]1,,ClCCl,,CN(C)C(=N)N(C)C,,val
US05136868,CCI.COc1cc(-n2nn[nH]c2=O)c(Cl)cc1F>>CCn1nnn(-c2cc(OC)c(F)cc2Cl)c1=O,,CS(C)=O,,[H-].[Na+],,val
US20070197478A1,CCOC(=O)N(Cc1ccccc1)c1cc(C(F)(F)F)nc(Cl)c1[N+](=O)[O-].N>>CCOC(=O)N(Cc1ccccc1)c1cc(C(F)(F)F)nc(N)c1[N+](=O)[O-],,C1CCOC1,,,,val
US20050239769A1,CC1(C)NC(=O)NC1=O.ClCCCBr>>CC1(C)NC(=O)N(CCCCl)C1=O,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20050137168A1,CCOC(C(=O)O)C(=O)NCc1ccc(C#N)cc1.NC(=NO)c1ccccc1>>CCOC(C(=O)NCc1ccc(C#N)cc1)c1nc(-c2ccccc2)no1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20140275087A1,BrC(Br)(Br)Br.Cn1cnc(S(=O)(=O)N2C[C@@H](C=O)[C@H](c3ccc(F)cc3)C2)c1>>Cn1cnc(S(=O)(=O)N2C[C@@H](C=C(Br)Br)[C@H](c3ccc(F)cc3)C2)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120046306A1,COc1cc(OCCOC(C)=O)ccc1[N+](=O)[O-]>>COc1cc(OCCOC(C)=O)ccc1N,[Pd],CCOC(C)=O,,,,val
US07514435B2,Cn1nc(C2CC2)cc1NC(=O)Nc1cccc(C(=O)c2cc(Br)n3ncnc(N)c23)c1>>Cn1nc(C2CC2)cc1NC(=O)Nc1cccc(C(=O)c2ccn3ncnc(N)c23)c1,[Pd],CCOC(C)=O,,CO,,val
US20060052378A1,Cc1ccccc1CN(C)CC(O)c1ccc2ccccc2c1>>Cc1cccc2c1CN(C)CC2c1ccc2ccccc2c1,,O=C(O)C(F)(F)F,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US06258975B1,CC(=O)O[C@H](CC(=O)c1ccccc1)C(=O)O>>O=C(O)[C@H](O)CCc1ccccc1,[Pd],CC(=O)O,,[H][H],,val
US20150197509A1,CC(C)N(CC(=O)OC(C)(C)C)S(=O)(=O)c1ccccc1>>CC(C)N(CC(=O)O)S(=O)(=O)c1ccccc1,,C1COCCO1,,Cl,,val
US20090324569A1,C1CNC1.COc1ccc(Cc2ccc(F)nc2)c(F)c1-c1cccc(Cl)c1>>COc1ccc(Cc2ccc(N3CCC3)nc2)c(F)c1-c1cccc(Cl)c1,,O,,C1CCC2=NCCCN2CC1,Cl,val
US20110021522A1,COc1ccc(B(O)O)c(OC)c1.Nc1cccc(Br)c1>>COc1ccc(-c2cccc(N)c2)c(OC)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20120225866A1,CC(C)(C)O.CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(CCC(=O)O)ccc21.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(CCNC(=O)OC(C)(C)C)ccc21,,CCN(CC)CC,,C1CCOC1,,val
US20040023945A1,BrCC1CC1.COc1ccc(C=O)cc1O>>COc1ccc(C=O)cc1OCC1CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060106029A1,CN(C)C=O.ClCc1cccc(Nc2nccs2)n1.O=C(c1cccc(Cl)c1F)N1CCNCC1>>CCN(C(C)C)C(C)C,,CN(C)C=O,,,,val
US20020032227A1,CON=C(C(N)=O)c1ccccc1COc1ccc(Cl)cc1>>CON=C(C#N)c1ccccc1COc1ccc(Cl)cc1,,CCOCC,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US20140080825A1,COc1ccc(CCl)cc1.N#CC1CC1>>COc1ccc(CC2(C#N)CC2)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US05723497,CCCCC(CC)COCCCCCCCCCCOCC1CO1.NCCO>>CCCCC(CC)COCCCCCCCCCCOCC(O)CNCCO,,CCO,,,,val
US20070244119A1,CCCN(c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)cc(-n2cc(/C(C)=N/S(=O)C(C)(C)C)nn2)c1)S(C)(=O)=O.[Li]Cc1ccccc1>>CCCN(c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)cc(-n2cc(C(C)(Cc3ccccc3)NS(=O)C(C)(C)C)nn2)c1)S(C)(=O)=O,,Cc1ccccc1,,C[Al](C)C,,val
US20130296290A1,CC(C)(C)OC(=O)N1CC(N(CC(=O)NN)C(=O)OC(C)(C)C)C1.O=C(O)C1CC[C@@H]2CN1C(=O)N2OCc1ccccc1>>CC(C)(C)OC(=O)N1CC(N(CC(=O)NNC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)C(=O)OC(C)(C)C)C1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090054402A1,Cc1ccccc1-c1cccc2c(CCC=Cc3cccc4ccccc34)c(C(=O)O)[nH]c12>>Cc1ccccc1-c1cccc2c(CCCCc3cccc4ccccc34)c(C(=O)O)[nH]c12,[Pd],CCO,CCOC(C)=O,,,val
US20020103211A1,CC(=O)O[C@H](C)CCCCn1c(=O)c2c(nc(CNOC(=O)C(F)(F)F)n2Cc2ccccc2)n(C)c1=O>>CC(=O)O[C@H](C)CCCCn1c(=O)c2[nH]c(CNOC(=O)C(F)(F)F)nc2n(C)c1=O,[Pd],CC(=O)O,,[H][H],,val
US20150246923A1,CN(C)CCNN.N#CCC(=O)C1CC1>>CN(C)CCn1nc(C2CC2)cc1N,,CCO,,Cl,Cl,val
US06365598B1,CO.Cc1ccc2c(Cl)nccc2c1[N+](=O)[O-]>>COc1nccc2c([N+](=O)[O-])c(C)ccc12,,CO,,C[O-].[Na+],,val
US05780505,CCCCOc1c(NC(C)(C)CC)c(=O)c1=O.Cc1ccc(C)c(CN)c1>>CCC(C)(C)Nc1c(NCc2cc(C)ccc2C)c(=O)c1=O,,C1CCOC1,,CCN(CC)CC,Cl,val
US20150218092A1,CCc1cc(N2CC=C(Oc3ccc(C4CC4)cc3)C2=O)ccc1OCCOC1CCCCO1>>CCc1cc(N2CC=C(Oc3ccc(C4CC4)cc3)C2=O)ccc1OCCO,,CO,,CS(=O)(=O)O,,val
US20140031360A1,CN(C)C(=O)c1ccc2c(c1)c(-c1ccnc(N3CCC(NC(=O)OC(C)(C)C)CC3)n1)nn2C1CCCCO1>>CN(C)C(=O)c1ccc2[nH]nc(-c3ccnc(N4CCC(N)CC4)n3)c2c1,,CCOC(C)=O,,Cl,,val
US20080275043A1,CC(C)(C)[Si](C)(C)O[C@H]1CC[C@@H](N2CCC(Cc3c(Cl)cc(OS(=O)(=O)C(F)(F)F)cc3Cl)C2=O)CC1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>Cn1cc(-c2cc(Cl)c(CC3CCN([C@@H]4CC[C@H](O[Si](C)(C)C(C)(C)C)CC4)C3=O)c(Cl)c2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US04454338,CS(=O)(=O)Oc1ccc2cc(C(=N)N)ccc2c1.O=C(O)COc1ccccc1>>CS(=O)(=O)O.N=C(N)c1ccc2cc(OC(=O)COc3ccccc3)ccc2c1,,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04177292,CN(C)[C@H]1CCc2ccccc2[C@H](O)C1.O=[N+]([O-])c1ccc(Cl)cc1>>CN(C)[C@H]1CCc2ccccc2[C@H](Oc2ccc([N+](=O)[O-])cc2)C1,,CS(C)=O,,[H-].[Na+],,val
US05344843,CCOC(=O)C(=O)c1ccc(OCC(=O)C2CCCCCCC2)cc1>>O=C(O)C(=O)c1ccc(OCC(=O)C2CCCCCCC2)cc1,,CO,,O,[Na+].[OH-],val
US20140249126A1,CC(=O)c1c[nH]c2c(Br)cccc2c1=O.CI>>CC(=O)c1cn(C)c2c(Br)cccc2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100160308A1,Cc1ccc(S(=O)(=O)OCCCN(C)C)cc1.NC(=O)c1sc(-n2cnc3ccc(O)cc32)nc1-c1cccc(Cl)c1>>CN(C)CCCOc1ccc2ncn(-c3nc(-c4cccc(Cl)c4)c(C(N)=O)s3)c2c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120309769A1,CCc1cccc(O)c1.COC(=O)[C@@H](C)O>>CCc1cccc(O[C@@H](C)C(=O)OC)c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120264749A1,COC(=O)c1ccc(OC(C)C)c(C)c1>>Cc1cc(C(=O)O)ccc1OC(C)C,,C1CCOC1,O,[Li+].[OH-],,val
US20090082308A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1cc2ccc(CNC(=O)OCc3ccccc3)cc2s1>>Nc1ccccc1NC(=O)c1cc2ccc(CNC(=O)OCc3ccccc3)cc2s1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150065522A1,CCc1c(C)[nH]c2c(-c3cnn(-c4cc(Br)ccn4)c3)cnn2c1=O.OCCO>>CCc1c(C)[nH]c2c(-c3cnn(-c4cc(OCCO)ccn4)c3)cnn2c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20120142717A1,C=Cc1ccc(Oc2cnc(C(F)(F)F)nc2)c(F)c1.OO>>OCCc1ccc(Oc2cnc(C(F)(F)F)nc2)c(F)c1,,C1CCOC1,,B1C2CCCC1CCC2,[Na+].[OH-],val
US08129361B2,CC(C)(C)OC(=O)NC1(CCc2ccc(OCCCc3ccc4c(c3)CCC4=O)c(C(F)(F)F)c2)COC(C)(C)OC1.Cl>>Cl.NC(CO)(CO)CCc1ccc(OCCCc2ccc3c(c2)CCC3=O)c(C(F)(F)F)c1,,CCO,,,,val
US05554746,COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.O=C(Nc1ccn(C2C(=O)N(O)C2CO)c(=O)n1)c1ccccc1>>COc1ccc(C(OCC2C(n3ccc(NC(=O)c4ccccc4)nc3=O)C(=O)N2O)(c2ccccc2)c2ccc(OC)cc2)cc1,,c1ccncc1,,,,val
US05284739,NC(=O)c1ccccc1NC(=O)C(F)(F)F>>O=c1[nH]c(C(F)(F)F)nc2ccccc12,,OCCO,,,,val
US20120245344A1,Nc1c(C(O)CCl)cc(Br)c(F)c1F>>Fc1c(Br)cc2cc[nH]c2c1F,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20140256700A1,CCOC(=O)c1ccc2[nH]c3cc(-c4c(C)noc4C)cc(C(=O)OC(C)(C)C)c3c2c1.Fc1ccc(CCl)cc1>>CCOC(=O)c1ccc2c(c1)c1c(C(=O)OC(C)(C)C)cc(-c3c(C)noc3C)cc1n2Cc1ccc(F)cc1,,CC(C)=O,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20090124604A1,CCN1CCN(c2ccc3ncn(-c4cc(C(=O)O)ccc4C)c(=O)c3c2)CC1.Nc1ccon1>>CCN1CCN(c2ccc3ncn(-c4cc(C(=O)Nc5ccon5)ccc4C)c(=O)c3c2)CC1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US20080269200A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.NC(=O)c1cc(Br)cc2cc[nH]c12>>CC(C)(C)OC(=O)N1CC=C(c2c[nH]c3c(C(N)=O)cc(Br)cc23)CC1,,CO,,C[O-].[Na+],,val
US20110263534A1,CC(C)(C)OC(=O)NN1CCN(CCO)CC1.O=C1CCC(=O)O1>>CC(C)(C)OC(=O)NN1CCN(CCOC(=O)CCC(=O)O)CC1,CN(C)c1ccncc1,ClC(Cl)Cl,,,,val
US20060270646A1,O=S(=O)(c1ccccc1)n1cc(-c2ccoc2)c2cc(-c3cccs3)cnc21>>c1csc(-c2cnc3[nH]cc(-c4ccoc4)c3c2)c1,,CCO,O,[Na+].[OH-],,val
US05824705,CI.Cc1ccccc1OCc1ccccc1N>>CNc1ccccc1COc1ccccc1C,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04581356,CC1NC(=O)NN=C1c1ccc2c(c1)CCC(=O)N2CCOCc1ccccc1>>CC1NC(=O)NN=C1c1ccc2c(c1)CCC(=O)N2CCO,,ClCCl,,BrB(Br)Br,CO,val
US20130331378A1,COC(=O)c1cc(CBr)cc(Cc2c(-c3ccccc3)nn3cc(OC)ccc23)c1.C[S-]>>COC(=O)c1cc(CSC)cc(Cc2c(-c3ccccc3)nn3cc(OC)ccc23)c1,,CO,,[Cl-].[NH4+],,val
US05025025,CC(C)(C)[Si](C)(C)OCCCCC1CCOC(=O)CC1.CI>>CC1CC(CCCCO[Si](C)(C)C(C)(C)C)CCOC1=O,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US09248117B2,CC(C)(CCS)NC(=O)OCc1ccccc1.OCC1CO1>>CC(C)(CCSCC(O)CO)NC(=O)OCc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130045286A1,CCC(=O)Nc1c[nH]c2ncc(Cl)c(N3CCC[C@@H](N(C)C(=O)OC(C)(C)C)C3)c12.ClCCl>>CCC(=O)Nc1c[nH]c2ncc(Cl)c(N3CCC[C@@H](NC)C3)c12.Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070099990A1,Cc1c(C)c2c(c(C)c1N)C(=O)C(C)(C)O2.Cc1ccc(Br)cc1>>Cc1ccc(C2(O)c3c(C)c(N)c(C)c(C)c3OC2(C)C)cc1,,C1CCOC1,O,CCCCCC,[Li]CCCC,val
US20160255837A1,CNc1ncc(C(F)(F)F)cc1NC(=O)c1ccc(Br)c2c1S(=O)(=O)C(C)C2>>CC1Cc2c(Br)ccc(-c3nc4cc(C(F)(F)F)cnc4n3C)c2S1(=O)=O,,CN1CCCC1=O,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20130090340A1,N#CCC(=O)O.O=Cc1cccc(F)c1>>N#CC=Cc1cccc(F)c1,,Cc1ccccc1,c1ccncc1,,,val
US05861414,CC(C)(C)OC(=O)CN1CCC(c2n[nH]c3cc(/C=C/C4CCN(C(=O)OC(C)(C)C)CC4)ccc23)CC1.ClCc1ccc(Cl)cc1>>CC(C)(C)OC(=O)CN1CCC(c2nn(Cc3ccc(Cl)cc3)c3cc(/C=C/C4CCN(C(=O)OC(C)(C)C)CC4)ccc23)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20160152624A1,CC(C)(C)OC(=O)Cc1ccc(I)cc1.Cc1nc(Cl)nc2c1C(C)CN2>>Cc1nc(Cl)nc2c1C(C)CN2c1ccc(CC(=O)OC(C)(C)C)cc1,[Cu]I,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20150344466A1,O=Cc1c(C(=O)NCC2CCOC2)noc1COCc1cccc(F)c1>>O=C(NCC1CCOC1)c1noc(COCc2cccc(F)c2)c1CO,,Cc1ccccc1,,CO,[BH4-].[Na+],val
US20090156578A1,CC(C)(C)[S@](N)=O.CCc1c(C(C)=O)oc2ccccc12>>CCc1c(C(C)=N[S@](=O)C(C)(C)C)oc2ccccc12,,C1CCOC1,,[Cl-].[Na+],,val
US20100210651A1,COC(=O)c1cc(O)ns1.Cc1onc(-c2ccccn2)c1CO>>COC(=O)c1cc(OCc2c(-c3ccccn3)noc2C)ns1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070259864A1,BrC(Br)(Br)Br.N#Cc1ccc(CCCO)cc1>>N#Cc1ccc(CCCBr)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04788206,COc1ccc(/C(=C\C=C\C(=O)O)c2ccccc2OC)cc1.O=[N+]([O-])c1ccc(O)cc1>>COc1ccc(/C(=C\C=C\C(=O)Oc2ccc([N+](=O)[O-])cc2)c2ccccc2OC)cc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20080167307A1,CCNC(=O)c1ccc(CN(CCc2csc(SC(C)(C)C(=O)OC(C)(C)C)n2)c2ncc(CC)cn2)cc1>>CCNC(=O)c1ccc(CN(CCc2csc(SC(C)(C)C(=O)O)n2)c2ncc(CC)cn2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090023763A1,Nc1nc(-c2cccc(F)c2)c(-c2ccncc2)cc1NC(=O)C1CC1>>Fc1cccc(-c2nc3[nH]c(C4CC4)nc3cc2-c2ccncc2)c1,,CC(=O)O,,,,val
US20100184750A1,BrCc1ccccc1Br.CCOC(=O)c1ccc(N2CCNCC2)cc1>>CCOC(=O)c1ccc(N2CCN(Cc3ccccc3Br)CC2)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US05155113,O=C(Cl)c1cccnc1.O=c1cc(O)c(Cl)c[nH]1>>O=C(Oc1cc(=O)[nH]cc1Cl)c1cccnc1,,c1ccncc1,,Cl,,val
US03978069,CCOC(=O)CC(Cl)(c1ccccc1)c1ccccc1.c1c[nH]cn1>>CCOC(=O)CC(c1ccccc1)(c1ccccc1)c1ncc[nH]1,,CC#N,,,,val
US20020086898A1,CCCc1cc(=O)oc2c3c(c4c(c12)OC(C)(C)C=C4)OC(C)C(C)C3O.CCCc1cc(=O)oc2c3c(c4c(c12)OC(C)(C)C=C4)O[C@H](C)[C@@H](C)[C@@H]3OC(C)=O>>CCCc1cc(=O)oc2c3c(c4c(c12)OC(C)(C)C=C4)O[C@H](C)[C@@H](C)[C@@H]3OC(C)=O.OC1CCc2ccccc2O1,,CC(=O)O,,,,val
US20120083475A1,CC(C)(C)OC(=O)N1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1>>CC(C)(C)OC(=O)N1CCC(c2c[nH]c3ccccc23)CC1,[Pd],CO,,O=C[O-].[NH4+],,val
US20050245603A1,CC(O)C(F)(F)C(F)(F)F.COc1ccc2cc([C@H](C)C(=O)O)ccc2c1>>COc1ccc2cc(C(C)C(=O)O[C@@H](C)C(F)(F)C(F)(F)F)ccc2c1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20090192163A1,O=C(O)Cc1cc(O)cc(Oc2ccc(S(=O)(=O)c3ccccc3)cc2F)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C(O)Cc1cc(Oc2ccc(S(=O)(=O)c3ccccc3)cc2F)cc(OS(=O)(=O)C(F)(F)F)c1,,ClCCl,O,c1ccncc1,,val
US20070078263A1,CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccc(Nc2ccccc2)cc1>>c1ccc(Nc2ccc(OC[C@H]3CCCN3)cc2)cc1,,C1COCCO1,,Cl,,val
US20010027200A1,O=C(NCc1ccco1)c1cc([N+](=O)[O-])ccc1Oc1cncc(Cl)c1>>Nc1ccc(Oc2cncc(Cl)c2)c(C(=O)NCc2ccco2)c1,[Ni],CO,,,,val
US04435403,BrCCCCBr.CCOC(=O)c1cc2c(cn1)[nH]c1ccc(N)cc12>>CCOC(=O)c1cc2c(cn1)[nH]c1ccc(N3CCCC3)cc12,,CCO,,CCN(C(C)C)C(C)C,,val
US05030641,CC1CCC(=O)O1.CN1CCC(N)CC1.O=C([O-])C(=O)[O-]>>CN1CCC(NC(=O)CCCCO)CC1.O=C(O)C(=O)O,,ClCCl,O,O=C([O-])[O-].[K+].[K+],,val
US20060287343A1,C#Cc1cc(F)ccc1CC(=O)O.N#CS[Pb]SC#N>>C#Cc1cc(F)ccc1CC(=O)N=C=S,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20060287542A1,CCCCCCC(O)CCCCCCCCCCC(=O)OCC.CCCCCCCCCCCCCCCCOS(=O)(=O)c1ccc(C)cc1>>CCCCCCCCCCCCCCCCOC(CCCCCC)CCCCCCCCCCC(=O)OCC,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20130096303A1,CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1CBr.CCCCP(CCCC)CCCC>>CCCC[P+](CCCC)(CCCC)Cc1c(-c2ccc(F)cc2)nc(N(C)S(C)(=O)=O)nc1C(C)C.[Br-],,Cc1ccccc1,,,,val
US20150105317A1,[N-]=[N+]=NCCO[C@@H]1O[C@H](CO[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H](OCc2ccccc2)[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)[C@H]1F>>NCCO[C@@H]1O[C@H](CO[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H](OCc2ccccc2)[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)[C@H]1F,[Pd],O,,,,val
US20120094972A1,CC1(C)CNc2cc(N3CCOCC3)ccc21.Cc1c(-c2ccccc2F)nc2cc(F)ccc2c1Cl>>Cc1c(-c2ccccc2F)nc2cc(F)ccc2c1N1CC(C)(C)c2ccc(N3CCOCC3)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20040058965A1,Cc1oc(-c2ccccc2)nc1COc1ccc(CCl)cc1.N#CCc1c(O)ccc2ccccc12>>Cc1oc(-c2ccccc2)nc1COc1ccc(COc2ccc3ccccc3c2CC#N)cc1,,O,,CN(C)C=O,[H-].[Na+],val
US20080262042A1,CC(C)O.CCOC(C)=O.CCOC(C)=O.CN(Cc1cn(S(=O)(=O)c2ccc(CO)o2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C>>CNCc1cn(S(=O)(=O)c2ccc(COC(C)=O)o2)c(-c2cccnc2F)c1F.O=C(O)/C=C/C(=O)O,,CC(C)O,,Cl,,val
US20140296200A1,COC(=O)C(=CN(C)C)c1cc(F)c(C#N)cc1C.NNc1ccc(C(=O)O)cn1>>Cc1cc(C#N)c(F)cc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O,,CC(C)O,O,CCN(C(C)C)C(C)C,Cl,val
US20070173508A1,CCCCC(CC)COC(=O)CCSc1ccc2c(ccc3ncnn32)c1.N#CC1(c2cccc(F)n2)CCOCC1>>N#CC1(c2cccc(Sc3ccc4c(ccc5ncnn54)c3)n2)CCOCC1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US04820727,CCOC(=O)N(CC(=O)OC(C)(C)C)C(=O)c1c(Cl)ccc2c(C(F)(F)F)c(OC)ccc12>>CCOC(=O)N(CC(=O)O)C(=O)c1c(Cl)ccc2c(C(F)(F)F)c(OC)ccc12,,O,O=CO,,,val
US20130131035A1,CNC(=O)c1cccc(N)c1.Fc1ccc(OC2CN(c3ccnc(Cl)n3)C2)cc1>>CNC(=O)c1cccc(Nc2nccc(N3CC(Oc4ccc(F)cc4)C3)n2)c1,,CC(C)O,,O=C(O)C(F)(F)F,,val
US03950393,BrBr.COc1ccc(N)c(CN(C)C)c1>>COc1cc(Br)c(N)c(CN(C)C)c1,,ClCCl,,,,val
US05374606,COC(=O)c1ccc(Cl)c(CSC)c1F.C[O-]>>COC(=O)c1ccc(Cl)c(CSC)c1OC,,C1CCOC1,,O,,val
US20140161801A1,Cc1ccc(S(N)(=O)=O)cc1.O=S(=O)([O-])CCC1(CCS(=O)(=O)[O-])CCC1>>Cc1ccc(S(=O)(=O)N2CC3(CCC3)C2)cc1,,CS(C)=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US04480095,CCCNCC1(C)C(CC)NC(CC)NC1CC>>CCCNCC(C)(C(N)CC)C(N)CC,,O,,Cl,,val
US20100239219A1,Cc1ccc(OCCCCCCCCCCCO)cc1.O=C(O)CCSC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cc1ccc(OCCCCCCCCCCCOC(=O)CCSC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US06326386B1,CCCN(C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1)C1CCCC1.O=C(O)C(F)(F)F>>CCCN(C(=O)c1cc(Cl)cc(OCCNc2ccncc2)c1)C1CCCCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20020103229A1,COc1ccc(C(=O)Cl)cc1.Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1>>COc1ccc(C(=O)Nc2cccc(-c3n[nH]c4ccc(-c5nc[nH]n5)cc34)c2)cc1,,c1ccncc1,,O,,val
US20110212937A1,O=C1CCOCC1c1ccccc1.O=C=NC(=O)Cl>>O=c1[nH]c(=O)c2c(o1)C(c1ccccc1)COC2,,CCOC(C)=O,,,,val
US20020119960A1,CC(C)(C)OC(=O)N1CCCCC1C(=O)N1CCC(C(=O)NC(CCCc2ccccc2)CCCc2ccccc2)CC1>>O=C(NC(CCCc1ccccc1)CCCc1ccccc1)C1CCN(C(=O)C2CCCCN2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050075334A1,CSc1c[nH]c2c(F)ccc([N+](=O)[O-])c12.O=S([O-])OO>>CS(=O)(=O)c1c[nH]c2c(F)ccc([N+](=O)[O-])c12,,O,,CO,,val
US20160237090A1,COC(=O)CC1(C[N+](=O)[O-])CCC1>>O=C1CC2(CCC2)CN1,[Ni],CO,,[H][H],,val
US20070293490A1,CI.CN(Cc1ccccc1)C1(C(N)=O)CN(C(=O)OC(C)(C)C)C1>>CNC(=O)C1(N(C)Cc2ccccc2)CN(C(=O)OC(C)(C)C)C1,,CN(C)C=O,,[H-].[Na+],,val
US20080280917A1,COc1ccc2c(OCCn3cc(Br)ccc3=O)ccnc2c1.NC(=O)c1ccccc1>>COc1ccc2c(OCCn3cc(NC(=O)c4ccccc4)ccc3=O)ccnc2c1,[Cu]I,Cc1ccccc1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06448293B1,COC(=O)c1ccc(Oc2ccc(SC)cc2)c(CN(C)C)c1>>CSc1ccc(Oc2ccc(C(=O)O)cc2CN(C)C)cc1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20150051154A1,CC(C)(CN)CN.CCOC=O.CO.ClCCl>>CC(C)(CNC=O)CNC=O,,ClCCl,,,,val
US20150065519A1,CC(C)Cc1cc(C(N)=S)ccn1.O=C(CBr)c1ccc(NS(=O)(=O)C(F)(F)F)cc1Cl>>CC(C)Cc1cc(-c2nc(-c3ccc(NS(=O)(=O)C(F)(F)F)cc3Cl)cs2)ccn1,,CCO,,,,val
US20030069297A1,CCOC(=O)c1c(C)[nH]c(C=O)c1CCCSC.O=S([O-])OO>>Cc1[nH]c(C=O)c(CCCS(C)(=O)=O)c1C(=O)O,,O,,CO,,val
US04649150,CCOC=NC#N.Cc1nc(-c2ccc(N)cc2)c[nH]1>>Cc1nc(-c2ccc(N=CNC#N)cc2)c[nH]1,,CCO,,,,val
US04746747,COc1cc(CCNC=O)cc2c1OCO2>>COc1c2c(cc3c1OCO3)CCN=C2,,ClCCl,,O=P(Cl)(Cl)Cl,,val
US20140371278A1,COC(=O)c1cc(SCc2ccccc2)c(F)c(F)c1Nc1ccccc1F.[N-]=[N+]=[N-]>>COC(=O)c1cc(SCc2ccccc2)c(N=[N+]=[N-])c(F)c1Nc1ccccc1F,,CN(C)C=O,,O,,val
US05446180,C=CCN([SiH](C)C)[SiH](C)C>>CC1CN([SiH](C)C)[Si]1(C)C,,Cc1ccccc1,,,,val
US05000775,CC(C)(C)Nc1nc(C(F)(F)F)c(C(=O)O)o1.O=S(Cl)Cl>>CC(C)(C)Nc1nc(C(F)(F)F)c(C(=O)Cl)o1,,CN(C)C=O,,,,val
US05440037,Nc1nc2nc[nH]c2c(=O)[nH]1.O=P(Cl)(Cl)Cl>>Nc1nc(Cl)c2[nH]cnc2n1,,O,,CN(C)C=O,,val
US20120082702A1,C1COCCN1.Nc1cc([N+](=O)[O-])ccc1C(=O)O>>Nc1cc([N+](=O)[O-])ccc1C(=O)N1CCOCC1,,CC#N,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US04806145,COc1cc(-n2nc(C)n(C(F)F)c2=O)ccc1C.O=S(=O)(Cl)Cl>>COc1cc(-n2nc(C)n(C(F)F)c2=O)c(Cl)cc1C,,ClC(Cl)Cl,ClCCl,,,val
US20090131467A1,NN.O=C(Cc1cccc(OC(F)(F)F)c1)c1c(O)c2cccnc2n(-c2cccc(C(F)(F)F)c2)c1=O>>O=c1c2c(Cc3cccc(OC(F)(F)F)c3)n[nH]c2c2cccnc2n1-c1cccc(C(F)(F)F)c1,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20160002273A1,CCOC(=O)CS.O=Cc1ccncc1Br>>CCOC(=O)c1cc2ccncc2s1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040138462A1,CC(C)(C)OC(=O)COc1ccc(S(=O)(=O)c2ccc(CCNC(=O)C(F)(F)F)cc2)cc1Cl>>CCOC(=O)COc1ccc(S(=O)(=O)c2ccc(CCN)cc2)cc1Cl,,CO,,[Na+].[OH-],,val
US20080119493A1,Br.CCCCCOCCCc1c(CC)nc2ncnn2c1N>>CCc1nc2ncnn2c(N)c1CCCBr,,CC(=O)O,,CC#N,O,val
US05262390,COC(=O)C(C)Oc1cc(C)ccc1CCl.Cn1c(=O)cnn(-c2ccc(O)cc2F)c1=O>>COC(=O)C(C)Oc1cc(C)ccc1COc1ccc(-n2ncc(=O)n(C)c2=O)c(F)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030176447A1,C#CCBr.Cc1nc2cc(OC[C@@H](O)CN3CCNCC3)ccc2s1>>C#CCN1CCN(C[C@H](O)COc2ccc3sc(C)nc3c2)CC1,,CC(C)=O,CO,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20100216746A1,CN.N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CBr)c2F)c1>>CNCc1ccc(Cl)c(Oc2cc(Cl)cc(C#N)c2)c1F,,C1CCOC1,ClCCl,CCOC(C)=O,O=C([O-])O.[Na+],val
US20050235428A1,COc1cccc(C(=O)O)c1O.NC(=O)c1ccccc1O>>COc1cccc2c(=O)nc(-c3ccccc3O)oc12,,Cc1ccccc1C,,O=S(Cl)Cl,c1ccncc1,val
US20090264403A1,CC(=O)N(C)C1CCCN(c2ccc(-n3ccc4cc(OC[C@@H]5CCCO5)ccc4c3=O)cc2)C1>>CNC1CCCN(c2ccc(-n3ccc4cc(OC[C@@H]5CCCO5)ccc4c3=O)cc2)C1,,O=S(=O)(O)O,,[Na+].[OH-],,val
US20020013466A1,COC(=O)C(C)Br.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(Oc3ccccc3O)c(Cl)cc2F)c1=O>>COC(=O)C(C)Oc1ccccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150057273A1,CC(C)(C)c1cc(N)n(-c2cccc(OCCN3CCOCC3)c2)n1.O=C(Cl)OCC(Cl)(Cl)Cl>>CC(C)(C)c1cc(NC(=O)OCC(Cl)(Cl)Cl)n(-c2cccc(OCCN3CCOCC3)c2)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20090143353A1,C=C(OCC)c1c(C)c(C#N)c2nc(C3CC3)oc2c1OC.O=C1CCC(=O)N1Br>>COc1c(C(=O)CBr)c(C)c(C#N)c2nc(C3CC3)oc12,,C1CCOC1,,O,,val
US20070043080A1,CC(C)C(=O)Nc1cccc(C2CCN(CCCCCCN)CC2)c1.O=C=Nc1cccc2ccccc12>>CC(C)C(=O)Nc1cccc(C2CCN(CCCCCCNC(=O)Nc3cccc4ccccc34)CC2)c1,,C1CCOC1,,,,val
US03974289,O=[N+]([O-])O.O=c1cc(O)c2ccc(Br)cc2o1>>O=c1oc2cc(Br)ccc2c(O)c1[N+](=O)[O-],,ClC(Cl)Cl,,,,val
US20050014791A1,C1CCNCC1.CN(C)C=O.O=C(O)CC(O)(CC(=O)O)C(=O)O>>O=Cc1ccccc1N1CCCCC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160096839A1,C#C[Si](C)(C)C.COc1cc(-c2cc(Cl)ccc2N)ncn1.C[Si](C)(C)N=[N+]=[N-]>>COc1cc(-c2cc(Cl)ccc2-n2cc([Si](C)(C)C)nn2)ncn1,,CC#N,,CC(C)CCON=O,,val
US04640917,Cc1ccc(Sc2c(Cl)cc(-n3ncc(=O)[nH]c3=O)cc2Cl)cc1>>Cc1ccc(Sc2c(Cl)cc(N3NCC(=O)NC3=O)cc2Cl)cc1,,CC(=O)O,,Cl,,val
US20140315949A1,CC(=O)c1ccc(Br)cc1OCC(=O)O>>Cc1coc2cc(Br)ccc12,,CC(=O)OC(C)=O,,CC(=O)[O-].[Na+],,val
US20090324581A1,CC(C)(C)OC(=O)CCN(CC(=O)N1CCc2cc(O)ccc21)C(=O)OC(C)(C)C.FC(F)(F)c1cc(CCl)ccc1C1CC1>>CC(C)(C)OC(=O)CCN(CC(=O)N1CCc2cc(OCc3ccc(C4CC4)c(C(F)(F)F)c3)ccc21)C(=O)OC(C)(C)C,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160194302A1,CN(C)C1CCN(C(=O)CCc2nccn2CCC(=O)O)CC1.Cl>>CN(C)C1CCN(C(=O)CCc2nccn2CCC(=O)O)CC1.Cl,,O,,,,val
US20090209583A1,CC(C)(C)OC(=O)NC1CCNCC1.IC1CCCC1>>CC(C)(C)OC(=O)NC1CCN(C2CCCC2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110224190A1,CN(C)Cc1cc(C(=O)O)c(F)c(C(F)(F)F)n1.C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CN(C5CCNCC5)C4)c3)ncnc21>>CN(C)Cc1cc(C(=O)N2CCC(N3CC(CC#N)(n4cc(-c5ncnc6[nH]ccc56)cn4)C3)CC2)c(F)c(C(F)(F)F)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US05726319,C=CCOC(=O)[C@H](N)CCc1ccccc1.CC(C)(CCC(=O)O)NC(=O)OCc1ccccc1>>C=CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)CCC(C)(C)NC(=O)OCc1ccccc1,,ClCCl,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20080167470A1,COC(=O)[C@@H](c1ccccc1)[C@H]1CCCCN1>>COC(=O)[C@H](c1ccccc1)[C@H]1CCCCN1,,O,,,,val
US20040106656A1,CC(C)(C)OC(=O)N[C@H](C(=O)[O-])[C@H]1CC[C@H](N)CC1.CCCCCCN=C=O.ClCCl>>CCCCCCNC(=O)N[C@@H]1CC[C@@H]([C@H](NC(=O)OC(C)(C)C)C(=O)OC)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120035237A1,Fc1cccc(F)c1CBr.O=C(Nc1c(F)cccc1F)c1ccn(Cc2cc(Cl)ccc2O)n1>>O=C(Nc1c(F)cccc1F)c1ccn(Cc2cc(Cl)ccc2OCc2c(F)cccc2F)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090221551A1,C[C@H]1CN(C(=O)OC(C)(C)C)c2nc3c(N)nc4ccccc4c3n21>>C[C@H]1CNc2nc3c(N)nc4ccccc4c3n21,,ClC(Cl)Cl,,CCO,Cl,val
US20100292207A1,C=O.CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NCC3CNC3)c2)CC1>>CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NCC3CN(C)C3)c2)CC1,,ClCCl,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20070259881A1,CC(C)(C)OC(=O)NCC(O)CNc1c([N+](=O)[O-])cnc2ccccc12>>CC(C)(C)OC(=O)NCC(O)CNc1c(N)cnc2ccccc12,[Pt],ClCCCl,,O=S(=O)([O-])[O-].[Mg+2],,val
US20110086909A1,CCOC(C)=O.C[C@H]1OC(=O)CC[C@H]1NC(=O)OC(C)(C)C>>CCCCOC(=O)N[C@@H]1CCC(=O)O[C@@H]1C,,ClC(Cl)Cl,,,,val
US20040209857A1,C=CCC(C(=O)OCc1ccccc1)c1cc(OC)c(OC)cc1S(=O)(=O)N1CCOCC1>>C=CCC(C(=O)O)c1cc(OC)c(OC)cc1S(=O)(=O)N1CCOCC1,,CO,O,[Na+].[OH-],,val
US04089956,CCOC(C)=O.Cc1ccc(S(=O)(=O)O)cc1.SCc1ccccc1.[N-]=[N+]=N[C@H]1C(=O)N[C@H]1CC=O.c1ccccc1>>[N-]=[N+]=N[C@H]1C(=O)N[C@H]1CC(SCc1ccccc1)SCc1ccccc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])O.[Na+],,val
US05721245,CI.O=C(O)Cc1c[nH]c2ccc(Br)cc12>>Cn1cc(CC(=O)O)c2cc(Br)ccc21,,C1CCOC1,,O,[H-].[Na+],val
US20120115903A1,CCOC(C)=O.CI.COc1ccc2[nH]cc(CC(=O)O)c2c1>>COC(=O)Cc1cn(C)c2ccc(OC)cc12,,CC(C)=O,,[K+].[OH-],,val
US20130203768A1,CC(C)(C)OC(=O)N1CC[C@H](Nc2ccnc3ccccc23)C1>>c1ccc2c(N[C@H]3CCNC3)ccnc2c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US04460580,NC(=O)c1cc(OCCNCc2ccccc2)ccc1O.c1ccc([C@@H]2CO2)cc1>>NC(=O)c1cc(OCCN(Cc2ccccc2)C[C@H](O)c2ccccc2)ccc1O,,CC(C)O,,,,val
US20100010053A1,CCOC(=O)C1CCN(Cc2c[nH]c3cc(-c4noc(-c5cnc(OC(C)C)c(Cl)c5)n4)ccc23)CC1>>CC(C)Oc1ncc(-c2nc(-c3ccc4c(CN5CCC(C(=O)O)CC5)c[nH]c4c3)no2)cc1Cl,,CC(C)O,O,Cl,[Na+].[OH-],val
US04758586,CCOC(=O)C=CC=Cc1c(Cc2ccccc2)[nH]c2ccc(OCc3ccccc3)cc12>>O=C(O)C=CC=Cc1cn(Cc2ccccc2)c2ccc(OCc3ccccc3)cc12,,CCO,O,[K+].[OH-],,val
US20130116232A1,COc1cc(CO)ccc1C.O=S(Cl)Cl>>COc1cc(CCl)ccc1C,,ClCCl,,,,val
US20100029710A1,CC1(C)C(=O)N(Br)C(=O)N1Br.Cc1ccnc(Cl)c1N>>Cc1cc(Br)nc(Cl)c1N,,ClCCl,,,,val
US20020128301A1,CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O.OCCO>>CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)OCCO,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20160207887A1,CS(=O)(=O)Cl.OCc1cc(Br)c(C(F)(F)F)cc1F>>CS(=O)(=O)OCc1cc(Br)c(C(F)(F)F)cc1F,,ClCCl,,O,,val
US06252080B1,O=C=O.Oc1ccc(Cl)c2cccnc12>>O=C(O)c1cc(Cl)c2cccnc2c1O,,O,,O=C([O-])[O-].[K+].[K+],,val
US20050014786A1,CC(C)(C)OC(=O)NC1CNc2ccc(Br)cc2C1.O=Cc1ccccc1>>CC(C)(C)OC(=O)NC1Cc2cc(Br)ccc2N(Cc2ccccc2)C1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04801590,CC1CC(=O)Nc2nc(Br)c3ncccc3c21>>CC1CC(=O)Nc2ncc3c(c21)CCCN3,[Pd],CC(=O)O,CCO,,,val
US20160016981A1,CCCCCCCCCCCCCCI.CCN(CC)C(=O)C1CCCNC1>>CCCCCCCCCCCCCCN1CCCC(C(=O)N(CC)CC)C1,,CCOCC,,CCO,,val
US20060205728A1,COC(=O)c1cccc(C(=O)[O-])c1.O=S(Cl)Cl>>COC(=O)c1cccc(C(=O)Cl)c1,CN(C)C=O,,,,,val
US20050250766A1,CCNCC.Cn1c(C#N)ccc1-c1ccc2c(c1)C1(CCCCC1)C(=NC#N)N2>>CCNCC.Cn1c(C#N)ccc1-c1ccc2c(c1)C1(CCCCC1)C(=NC#N)N2,,C1CCOC1,,,,val
US20100112090A1,O=[N+]([O-])O.Oc1cc(O)nc(CF)n1>>O=[N+]([O-])c1c(O)nc(CF)nc1O,,O,,CC(=O)O,,val
US05194433,CC(C)(C)OC(=O)C(C)(C)O/N=C(\C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CI)CS(=O)[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1.Oc1cc2cnncc2cc1O>>CC(C)(C)OC(=O)C(C)(C)O/N=C(\C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(Cn3cc4cc(O)c(=O)cc-4cn3)CS(=O)[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,CCOC(C)=O,CN(C)C=O,Br,CCN(CC)CC,val
US20110306606A1,O=[N+]([O-])c1ccc(N2CCCC(CO)C2)c(F)c1>>Nc1ccc(N2CCCC(CO)C2)c(F)c1,[Pd],CCOC(C)=O,,,,val
US20040142993A1,COC(=O)c1cc(C#N)ccc1Nc1ccc(C(F)(F)F)cc1Nc1ccc(C#N)cc1C(=O)OC>>N#Cc1ccc(Nc2ccc(C(F)(F)F)cc2Nc2ccc(C#N)cc2C(=O)O)c(C(=O)O)c1,,C1CCOC1,O,[Li]O,,val
US20070072911A1,CS(=O)(=O)Cl.OCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CS(=O)(=O)OCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,,ClCCl,,CCN(CC)CC,,val
US20100292207A1,Fc1cc(F)cc(Br)c1.N#Cc1cc(C=O)ccc1F>>N#Cc1cc(C(O)c2cc(F)cc(F)c2)ccc1F,,C1CCOC1,,[Mg],,val
US20150152108A1,Cc1cc(-c2ccc3c(n2)N[C@H]2CCN3C2)ccn1.Cn1cnc(N)n1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cc(-c2ccc3c(n2)N(C(=O)Nc2ncn(C)n2)[C@H]2CCN3C2)ccn1,,C1CCOC1,,CCN(CC)CC,,val
US20090005530A1,C=CCOC(=O)CCCC.CO[SiH](OC)OC>>CCCCC(=O)OCCC[Si](OC)(OC)OC,[Pt],,,,,val
US20100160302A1,CN1CCN(CC23CC4CC(C2)C(N)(C4)C3)CC1.N#C[C@@H]1CCCN1C(=O)CCl>>CN1CCN(CC23CC4CC(C2)C(NCC(=O)N2CCC[C@H]2C#N)(C4)C3)CC1,,CCOC(C)=O,CS(C)=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20160168158A1,Clc1ccccc1CBr.FC1(F)CCN(c2nc(C3CC3)nc3[nH]nnc23)C1>>FC1(F)CCN(c2nc(C3CC3)nc3c2nnn3Cc2ccccc2Cl)C1,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US05998433,C=O.CNC.Cl.O=C(O)c1ccc(C(=O)c2cccc(Cl)c2Cl)cc1.c1cc2c(o1)CNCC2>>CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc(C(=O)c3cccc(Cl)c3Cl)cc1)CC2.Cl,,ClCCl,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20120277224A1,COC(=O)CC(=O)c1ccc(Cl)cc1OC.Nc1[nH]ncc1-c1ccccn1>>COc1cc(Cl)ccc1-c1cc(=O)n2ncc(-c3ccccn3)c2[nH]1,,CC(=O)O,,,,val
US08742113B2,CCOC(=O)C1=C(NC2CCCC2)OC(=Cc2c[nH]c3ncccc23)C1=O>>O=C1C=C(NC2CCCC2)OC1=Cc1c[nH]c2ncccc12,,CCO,,[K+].[OH-],,val
US20110190227A1,CCOC(=O)Cc1cccc(Oc2ccc(-c3cnn(C)c3)cc2CSc2ccccc2)c1>>Cn1cc(-c2ccc(Oc3cccc(CC(=O)O)c3)c(CSc3ccccc3)c2)cn1,,COCCOC,O,[Li+].[OH-],,val
US20080167361A1,BrBr.O=S(=O)(c1ccccc1)n1ccc2cc(F)ccc21>>O=S(=O)(c1ccccc1)n1cc(Br)c2cc(F)ccc21,,CN(C)C=O,,[Cl-].[NH4+],,val
US20100076229A1,O=S(Cl)Cl.O=[N+]([O-])c1ccccc1CC(O)C1CC1>>O=[N+]([O-])c1ccccc1CC(Cl)C1CC1,,Cc1ccccc1,,,,val
US20150266848A1,Clc1ccccc1/C=C/COCc1ccccc1.O=C(OO)c1cccc(Cl)c1>>Clc1ccccc1C1OC1COCc1ccccc1,,ClCCl,,,,val
US20060167053A1,CC(C)Br.COC(=O)c1cc(O)cc(I)c1>>COC(=O)c1cc(I)cc(OC(C)C)c1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20140046069A1,CCC(=O)OC(=O)CC.NCc1ccc(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(C(F)(F)F)C2)nc1C(F)(F)F>>CCC(=O)NCc1ccc(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(C(F)(F)F)C2)nc1C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20150018422A1,CCOC(=O)CC(c1cccc(COc2ccc(-c3cc(OC)ccc3F)c(OCOC)c2)c1)C1CC1>>CCOC(=O)CC(c1cccc(COc2ccc(-c3cc(OC)ccc3F)c(O)c2)c1)C1CC1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US06706216B1,CC(=O)CC(C)C.CC(C)=O.CCC(C)=O.Nc1ccc(N)cc1.Nc1ccc(Nc2ccccc2)cc1>>CC(=O)CCC(C)C.O=C1CCCC1.O=C1CCCCC1,,CC(=O)CC(C)C,,,,val
US20030069297A1,Cc1[nH]c(C=O)c(C)c1CCC(=O)N1CCN(C)CC1.O=C1Cc2c(cccc2-c2ccc(Cl)cc2)N1>>Cc1[nH]c(C=C2C(=O)Nc3cccc(-c4ccc(Cl)cc4)c32)c(C)c1CCC(=O)N1CCN(C)CC1,C1CCNCC1,CCO,,,,val
US20120035214A1,CC(=O)OCC(=O)NCCc1ccccc1-c1onc([C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(O)c2ccc(F)c(F)c2)c1Br>>CC(C)(C)OC(=O)N1CC[C@](O)(c2ccc(F)c(F)c2)[C@@H](c2noc(-c3ccccc3CCNC(=O)CO)c2Br)C1,,C1CCOC1,,[Li+].[OH-],,val
US20090186879A1,C[Si](C)(C)C(F)(F)F.O=Cc1cccc2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl>>OC(c1cccc2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl)C(F)(F)F,,C1CCOC1,Cl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090221603A1,COCC1CNCCN1C(c1ccccc1)c1ccccc1.O=C(O)CNC(c1ccccc1)c1ccccc1>>COCC1CN(C(=O)CNC(c2ccccc2)c2ccccc2)CCN1C(c1ccccc1)c1ccccc1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20080015202A1,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccc(C=O)s1>>COC(=O)/C=C/c1ccc(C=O)s1,,ClC(Cl)Cl,,,,val
US20070072866A1,CCNc1nccc(C(=O)CC(O)(C(=O)OCC)C(=O)OCC)n1.NN>>CCNc1nccc(-c2cc(C(=O)OCC)c(=O)[nH]n2)n1,,CCO,,Cl,,val
US20070185136A1,COC(=O)[C@H](C)N(c1ccc(Cl)cc1Cc1c(F)cccc1F)S(=O)(=O)c1ccc(OC)c(OC)c1>>COc1ccc(S(=O)(=O)N(c2ccc(Cl)cc2Cc2c(F)cccc2F)C(C)CO)cc1OC,,C1CCOC1,CCOC(C)=O,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20080015203A1,CCn1ccc(N)n1.C[C@@H](CO[Si](C)(C)C(C)(C)C)Oc1cc(OCc2ccccc2)cc(C(=O)O)c1>>CCn1ccc(NC(=O)c2cc(OCc3ccccc3)cc(O[C@@H](C)CO[Si](C)(C)C(C)(C)C)c2)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150291595A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CS(=O)(=O)Nc1cc(I)cc(N2CCOCC2)c1>>CC1(C)OB(c2cc(NS(C)(=O)=O)cc(N3CCOCC3)c2)OC1(C)C,,C1COCCO1,CCOC(C)=O,O,CC(=O)[O-].[K+],val
US05071856,CCO.NO.O=C(CCC1(C(=O)N2CCNCC2)Cc2ccccc2NC1=O)c1ccc(Cl)cc1>>O=C1CCc2cc(C(=O)N3CCN(CCC(=NO)C(=O)c4ccc(Cl)cc4)CC3)ccc2N1,,O,,Cl,CC(=O)[O-].[Na+],val
US20050054658A1,Clc1ncnc2[nH]ncc12.N[C@@H]1CC[C@@H](OCCc2ccccc2)CC1>>c1ccc(CCOC2CCC(Nc3ncnc4[nH]ncc34)CC2)cc1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20130150343A1,CCN(C(C)C)C(C)C.C[C@@H](CO)Oc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)c1.C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](N)c4ccccc43)cn12>>C[C@@H](CN(C)C)Oc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCC[C@@H]5C)n4c3)c3ccccc32)c1.O=CO,,C1COCCO1,,,,val
US20080167378A1,Cc1ccc(B(O)O)cc1.O=Cc1cccc(O)c1>>Cc1ccc(Oc2cccc(C=O)c2)cc1,,ClCCl,,CCN(CC)CC,,val
US20160046592A1,Cn1cnc(CN)c1.O=C(CBr)OCc1ccccc1>>Cn1cnc(CNCC(=O)OCc2ccccc2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20030220524A1,CCS.CS(=O)C(Cl)(Cl)S(C)(=O)=O>>CCSSCS(C)(=O)=O,,c1ccncc1,,ClC(Cl)Cl,,val
US20150353497A1,C1CCNC1.O=C1CCC(c2ccc3c(C(=O)NCC4CCC(F)(F)CC4)c(Cl)ccc3n2)C1>>O=C(NCC1CCC(F)(F)CC1)c1c(Cl)ccc2nc(C3CCC(N4CCCC4)C3)ccc12,,CC(=O)O,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090270351A1,CO[PH](=O)CCc1ccc(C(=O)Nc2cc(-c3cccs3)ccc2NC(=O)OC(C)(C)C)cc1>>CO[PH](=O)CCc1ccc(C(=O)Nc2cc(-c3cccs3)ccc2N)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030166800A1,CCOC(=O)C1(CC(C)=O)CCc2ccccc2C1=O>>O=C1C=C2c3ccccc3CCC2C1,,O,,[K+].[OH-],,val
US20100093703A1,Br.CN(C)CCNc1ccc(Cl)nn1>>CN(C)CCNc1ccc(Br)nn1,,O,,[Na+].[OH-],,val
US20120115811A1,NNC(N)=S.O=C(O)c1ccnc(Cl)c1>>NC(=S)NNC(=O)c1ccnc(Cl)c1,,O=S(Cl)Cl,,c1ccncc1,,val
US20140274696A1,COC(=O)c1nc(-c2ccc(Br)c(F)c2)cc(NC(C)=O)c1Cl>>COC(=O)c1nc(-c2ccc(Br)c(F)c2)cc(N)c1Cl,,CO,,CC(=O)Cl,,val
US04812470,Br.C=[N+]=[N-].CC(=O)OCCCCCCCCC(=O)Cl>>CC(=O)OCCCCCCCCC(=O)CBr,,CCOCC,,,,val
US20110021494A1,CCOC(=O)c1nc2c(s1)CN(C(=S)Nc1ccccc1)CC2.CI>>CCOC(=O)c1nc2c(s1)CN(/C(=N/c1ccccc1)SC)CC2,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040235826A1,CC(C)(C)OC(=O)n1c(-c2cc3ccccc3nc2Cl)cc2cc(CO)ccc21>>CC(C)(C)OC(=O)n1c(-c2cc3ccccc3nc2Cl)cc2cc(C=O)ccc21,O=[Mn]=O,ClCCl,,,,val
US20120208839A1,CNc1nc(OCCOC)c(C(=O)N[C@@H]2CC[C@@H](C(F)(F)F)CC2)cc1[N+](=O)[O-]>>CNc1nc(OCCOC)c(C(=O)N[C@@H]2CC[C@@H](C(F)(F)F)CC2)cc1N,[Ni],C1CCOC1,,CO,,val
US20160002228A1,CC(C)(C)OC(=O)N1CC(C(=O)O)C1.CI>>COC(=O)C1CN(C(=O)OC(C)(C)C)C1,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110166123A1,CCOC(=O)C=CN(C)C.O=C(O)c1cc(Br)ccc1Br>>CCOC(=O)/C(=C\N(C)C)C(=O)c1cc(Br)ccc1Br,,CCOC(C)=O,ClCCl,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20060217365A1,c1ccc2c(c1)N=C(N1CCNCC1)c1ccccc1S2>>c1ccc2c(c1)N=C(N1CCNCC1)c1ccccc1S2,,Cc1ccccc1,,Cl,,val
US20110183989A1,CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)C(C(=O)O)C1.COS(=O)(=O)OC>>COC(=O)C1CN(C(=O)OC(C)(C)C)CCN1C(=O)OCc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100130468A1,O=C(O)c1cc(Br)c(F)c2c1NCC2>>O=C(O)c1cc(Br)c(F)c2cc[nH]c12,,ClC(Cl)Cl,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20140135336A1,CC(C)OB(OC(C)C)OC(C)C.Cn1ncc(Br)c1Cc1ccccc1>>Cn1ncc(B(O)O)c1Cc1ccccc1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20150038437A1,C=Cc1c(-c2ccc3c(ccn3C)c2)nc(OC(C)(C)C)c(C(=O)OC(C)(C)C)c1OC(C)(C)C>>C=CC1C(O)=C(C(=O)O)C(=O)NC1c1ccc2c(ccn2C)c1,,C1COCCO1,,Cl,,val
US20140142114A1,CC(C)(C)OC(=O)N1CCNCC1.Clc1ccc2nc(Cl)ccc2c1>>CC(C)(C)OC(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06362198B1,CCOC(=O)N(Cc1ccccc1)C1CC(C)N(C(=O)Cl)c2cc(OC)c(OC)cc21.OCC(F)(F)F>>CCOC(=O)N(Cc1ccccc1)[C@@H]1C[C@H](C)N(C(=O)OCC(F)(F)F)c2cc(OC)c(OC)cc21,,C1COCCO1,,[H-].[Na+],,val
US20050124691A1,CC(C)(C)NO.O=Cc1ccc(OCc2ccccc2)cc1>>CC(C)(C)[N+]([O-])=Cc1ccc(OCc2ccccc2)cc1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20130005710A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOc1ccc(Br)c(F)c1>>CCOc1ccc(B2OC(C)(C)C(C)(C)O2)c(F)c1,,CN(C)C=O,,O,CC(=O)[O-].[K+],val
US20040082611A1,CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)C(CC=O)C1.[PH3+]Cc1cccs1>>CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)C(CC=Cc2cccs2)C1,,C1CCOC1,ClC(Cl)Cl,C1CCC2=NCCCN2CC1,,val
US20090281103A1,CC(C)(C)[Si](C)(C)Cl.COC/C=C/c1cc(O)cc(C=O)c1>>COC/C=C/c1cc(C=O)cc(O[Si](C)(C)C(C)(C)C)c1,,CN(C)C=O,,c1c[nH]cn1,,val
US20140080819A1,CC(C)(C)[S@](=O)N[C@@](CCO)(c1cc(Br)ccc1F)C(F)F>>N[C@@](CCO)(c1cc(Br)ccc1F)C(F)F,,C1CCOC1,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20030134859A1,CC=O.CCNc1ccc(-c2ccc(NC(=O)c3cc([N+](=O)[O-])ccc3Cl)cc2)cc1>>CCN(CC)c1ccc(-c2ccc(NC(=O)c3cc([N+](=O)[O-])ccc3Cl)cc2)cc1,,C1CCOC1,O,CC(=O)O,O=C([O-])O.[Na+],val
US05866684,C=CC[Mg]Br.CC1(C)OB(C(Cl)Cl)OC1(C)C>>C=CCC(Cl)B1OC(C)(C)C(C)(C)O1,,C1CCOC1,,,,val
US20140249129A1,CS(=O)(=O)CCBr.N#Cc1ccc(C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)CCC3)cc1>>CS(=O)(=O)CCN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130336921A1,Cc1ccc(-n2ccc(NC(=O)c3cc(Cl)ccc3[N+](=O)[O-])n2)cc1C>>Cc1ccc(-n2ccc(NC(=O)c3cc(Cl)ccc3N)n2)cc1C,[Zn],CC(=O)O,,,,val
US20140045814A1,COc1cc(CCc2cnc3[nH]c(-c4ccc(N5CCN(C)CC5)cc4)c(Br)c3n2)cc(OC)c1.C[Si](C)(C)CCOCCl>>COc1cc(CCc2cnc3c(n2)c(Br)c(-c2ccc(N4CCN(C)CC4)cc2)n3COCC[Si](C)(C)C)cc(OC)c1,,C1CCOC1,,[H-].[Na+],,val
US04277470,C1CCNC1.COc1ccccc1C1C2CCC(C2)C12CCC(SC)=N2.I>>COc1ccccc1C1C2CCC(C2)C12CCC(N1CCCC1)=N2.I,,CCO,,,,val
US20110152295A1,CCOC(=O)c1cnc(Cl)nc1>>O=C(O)c1cnc(Cl)nc1,,C1CCOC1,O,Cl,[Na+].[OH-],val
US05399291,CCCCCCCCCCOc1ccc(C(=O)O)cc1.CCCCOCC(F)(F)C(F)(F)C(F)(F)COc1ccc(O)cc1>>CCCCCCCCCCOc1ccc(C(=O)Oc2ccc(OCC(F)(F)C(F)(F)C(F)(F)COCCCC)cc2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20130150339A1,C=CC[Sn](CCCC)(CCCC)CCCC.COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(-c4ccc(C(F)(F)F)cc4Br)nccc3c2)c(OC)c1>>C=CCc1cc(C(F)(F)F)ccc1-c1nccc2cc(S(=O)(=O)N(Cc3ccc(OC)cc3OC)c3nccs3)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20120040981A1,COC(=O)Cl.O=C1CCNCC1>>COC(=O)N1CCC(=O)CC1,,O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130331372A1,Cc1nc(Cl)ccc1Br.O=C1CCC(=O)N1Br>>Clc1ccc(Br)c(CBr)n1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20110053907A1,COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=O)CO)CC2)n1.CS(=O)(=O)Cl>>COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=O)COS(C)(=O)=O)CC2)n1,,ClCCl,O,CCN(CC)CC,,val
US20090124596A1,CC(C)(C)OC(=O)N1CCN(CC(=O)N[C@@H]2CC[C@H](n3c(=O)c4cc(F)cnc4n(-c4cccc(-c5ccccc5)c4)c3=O)CC2)CC1>>O=C(CN1CCNCC1)N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3cccc(-c4ccccc4)c3)c2=O)CC1,,C1COCCO1,,Cl,,val
US20130005753A1,CC(C)(C)CC(=O)OBr.O=C(Nc1cccc(C(F)(F)F)c1)n1ccc2cc(Oc3ncnc4c3CCNC4)ccc21>>CC(C)(C)OC(=O)CN1CCc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cccc(C(F)(F)F)c3)c2)C1,,CC#N,,,,val
US20100317568A1,COC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2F)CC1>>COC(=O)N1CCN(c2ccc(N)cc2F)CC1,[Pd],CCOC(C)=O,,,,val
US05618821,Cc1cc(-c2nnn(C)n2)cc(C)c1OCCCC=O.O=S(=O)(c1ccccc1)n1ccc2cccnc21>>Cc1cc(-c2nnn(C)n2)cc(C)c1OCCCC(O)c1cc2cccnc2[nH]1,,C1CCOC1,O,Cl,[Li]CCCC,val
US20130053563A1,CC(Cl)OC(=O)O[C@@H]1CCCC[C@H]1C.COc1cc(OCCO)c(F)c(C(Nc2ccc(C(N)=NC(=O)c3ccc(C)cc3)cc2)c2nn(-c3ncccn3)c(=O)[nH]2)c1>>COc1cc(OCCO)c(F)c(C(Nc2ccc(C(N)=NC(=O)c3ccc(C)cc3)cc2)c2nc(OC(C)OC(=O)O[C@@H]3CCCC[C@H]3C)n(-c3ncccn3)n2)c1,,CN(C)C=O,,O=C([O-])O.[K+],,val
US20090062267A1,COC(=O)[C@H](Cc1ccc(CCCC(C)O)nc1)NC(=O)OC(C)(C)C>>COC(=O)[C@H](Cc1ccc(CCCC(C)=O)nc1)NC(=O)OC(C)(C)C,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US08475686B2,c1ccc(C2=NC(c3cccc(C4N=C(c5ccccc5)NC5=C4CCc4c(-c6ccccc6)cc(-c6ccccc6)nc45)c3)C3=C(N2)c2nc(-c4ccccc4)cc(-c4ccccc4)c2CC3)cc1>>c1ccc(-c2cc(-c3ccccc3)c3ccc4c(-c5cccc(-c6nc(-c7ccccc7)nc7c6ccc6c(-c8ccccc8)cc(-c8ccccc8)nc67)c5)nc(-c5ccccc5)nc4c3n2)cc1,[Pd],OCCOCCO,,,,val
US20100087429A1,COC(C)(C)C#Cc1cnc2c(c1)[C@]1(COC(N)=N1)c1cc(OS(=O)(=O)C(F)(F)F)ccc1O2.OB(O)c1cccnc1>>COC(C)(C)C#Cc1cnc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cccnc3)ccc1O2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110086843A1,CC(=O)Nc1nc(C)c(-c2ccc(S(=O)(=O)Cl)s2)s1.CCN(CC)CCNC>>CCN(CC)CCN(C)S(=O)(=O)c1ccc(-c2sc(NC(C)=O)nc2C)s1,,ClCCl,,CCN(CC)CC,,val
US20110065695A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC[C@@]1(c2cc([N+](=O)[O-])ccc2F)CCSC(N)=N1>>CC[C@@]1(c2cc([N+](=O)[O-])ccc2F)CCSC(NC(=O)OC(C)(C)C)=N1,,ClCCl,,CCN(CC)CC,,val
US20070117822A1,C=CC#N.COc1ccc(-c2cnc(Cl)c(C=O)c2)cc1>>C=C(C#N)C(O)c1cc(-c2ccc(OC)cc2)cnc1Cl,,CCOCC,,C1CN2CCN1CC2,,val
US05264454,O=C(Nc1cc2c(cc1C(=O)c1ccccc1Cl)CCC2)c1ccccc1Cl>>Nc1cc2c(cc1C(=O)c1ccccc1Cl)CCC2,,O=S(=O)(O)O,,N,,val
US05405861,Br.C[C@@H](S)[C@](O)(Cn1cncn1)c1ccc(F)cc1F>>Br.C[C@@H](S)[C@](O)(Cn1cncn1)c1ccc(F)cc1F,,CCCCCC,CCOC(C)=O,CC(=O)O,,val
US20120238587A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=S(=O)(Nc1cncc(Br)c1)c1ccccc1>>CC1(C)OB(c2cncc(NS(=O)(=O)c3ccccc3)c2)OC1(C)C,,C1COCCO1,,CC(=O)[O-].[K+],,val
US04273779,COC(=O)c1ccc(N)cn1.O=Cc1cccc(F)c1>>COC(=O)c1ccc(N=Cc2cccc(F)c2)cn1,,c1ccccc1,,,,val
US20130158009A1,CCc1cnc(N2CCC(N3CC[C@H](Oc4cc(C)c(Br)cc4F)C3=O)CC2)nc1.N#C[Cu]>>CCc1cnc(N2CCC(N3CC[C@H](Oc4cc(C)c(C#N)cc4F)C3=O)CC2)nc1,,CN1CCCC1=O,,,,val
US20070254866A1,NCCNc1ccccn1.Nc1c(F)c(F)cc2c1c(=O)c(C(=O)O)cn2C1CCOCC1>>Nc1c(F)c(NCCNc2ccccn2)cc2c1c(=O)c(C(=O)O)cn2C1CCOCC1,,CS(C)=O,,CCN(CC)CC,,val
US04298739,CN(C(=O)CCCCl)C1CCCCC1.Cn1c(=O)ccc2cc(O)ccc21>>CN(C(=O)CCCOc1ccc2c(ccc(=O)n2C)c1)C1CCCCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080167378A1,Brc1ccccn1.OCc1cccc(O)c1>>O=Cc1cccc(Oc2ccccn2)c1,,c1ccncc1,,O=C([O-])[O-].[K+].[K+],,val
US20070167443A1,CON(C)C(=O)c1cn(Cc2cccc(C)n2)c2ccccc2c1=O.Clc1ccc(I)cn1>>Cc1cccc(Cn2cc(C(=O)c3ccc(Cl)nc3)c(=O)c3ccccc32)n1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20120053180A1,O=C(NC1CCC(c2nc(CCl)cs2)CC1)OCc1ccccc1.Oc1ccc(-n2cnnn2)cc1>>O=C(NC1CCC(c2nc(COc3ccc(-n4cnnn4)cc3)cs2)CC1)OCc1ccccc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20140309244A1,CO/N=C(\C)c1cccc(C#CCON2C(=O)c3ccccc3C2=O)n1>>CO/N=C(\C)c1cccc(CCCON2C(=O)c3ccccc3C2=O)n1,[Pd],C1CCOC1,,,,val
US20090247519A1,COc1ccccc1-c1cc(OC(C)(C)C)c2ccccc2n1.Cc1ccc(S(=O)(=O)O)cc1>>COc1ccccc1-c1cc(O)c2ccccc2n1.Cc1ccc(S(=O)(=O)O)cc1,,C1CCOC1,,,,val
US20060116390A1,C=C1CC(=O)O1.O=[N+]([O-])c1ccc(CO)cc1>>CC(=O)CC(=O)OCc1ccc([N+](=O)[O-])cc1,O,ClCCl,,CCN(CC)CC,,val
US20090192188A1,CNC(=O)[C@@H](O)c1ccccc1.Cc1ccc(S(=O)(=O)Cl)cc1>>CNC(=O)[C@@H](OS(=O)(=O)c1ccc(C)cc1)c1ccccc1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US04579862,CC(C)(C)CO.O=C(Cl)CCCCCBr>>CC(C)(C)COC(=O)CCCCCBr,,c1ccccc1,,,,val
US20130296317A1,CC(C)(C)OC(=O)N1CCc2c(-c3cc[nH]n3)sc(S(C)(=O)=O)c2C1=O.SC1CCCC1>>O=C1NCCc2c(-c3cc[nH]n3)sc(SC3CCCC3)c21,,C1CCOC1,,[H-].[Na+],,val
US06159988,C1CCC2OC2C1.COc1ccc(C=O)cc1.COc1cccc(OC)c1OC>>COc1cc(OC)c([C@@H]2CCCC[C@H]2O)c(OC)c1,,ClCCl,O,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04423047,Fc1cnc(Cl)nc1.Sc1ccccc1>>Fc1cnc(Sc2ccccc2)nc1,,CCO,,C,C[O-].[Na+],val
US20100168154A1,Clc1ccc2c(c1)C(C1CCCCC1)NCC2.O=C(Cl)CCl>>O=C(CCl)N1CCc2ccc(Cl)cc2C1C1CCCCC1,,CCOC(C)=O,,Cl,O=C([O-])O.[Na+],val
US04237305,COC(=O)C(CCOc1ccc(C(=O)C(=O)O)cc1)NC(=O)OC(C)(C)C.O=c1n(Cl)c(=O)n(Cl)c(=O)n1Cl>>COC(=O)C(CCOc1ccc(C(=O)C(=O)O)cc1Cl)NC(=O)OC(C)(C)C,,CO,ClC(Cl)Cl,,,val
US20160068531A1,CC(=O)OC(C)=O.NS(=O)(=O)CCCn1c(CN2C(=O)C3(CC3)c3ccncc32)cc2cc(Cl)cnc21>>CC(=O)NS(=O)(=O)CCCn1c(CN2C(=O)C3(CC3)c3ccncc32)cc2cc(Cl)cnc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20160039794A1,O=[N+]([O-])c1ccc(CN2CCCCC2)cc1[N+](=O)[O-]>>Nc1ccc(CN2CCCCC2)cc1N,[Pd],CCO,,,,val
US20160168139A1,CON(C)C(=O)c1cccc(CO)n1.CS(=O)(=O)Cl>>CON(C)C(=O)c1cccc(COS(C)(=O)=O)n1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20050153955A1,O=C(O)CC1=CCNC(=O)c2[nH]c3ccc(F)cc3c21.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=NC(=O)CC1=CCNC(=O)c2[nH]c3ccc(F)cc3c21,,CN(C)C=O,,CCN(CC)CC,CCOCC,val
US04215195,C=C(C)C(=O)NCCCN.C=C1CC(=O)O1>>C=C(C)C(=O)NCCCNC(=O)CC(C)=O,,CO,,CCN(CC)CC,Cl,val
US20130150357A1,C[C@@H](O)C(=O)[O-].ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)[C@@H](C)OS(=O)(=O)C(F)(F)F,,ClCCl,,Cc1cccc(C)n1,,val
US20100168039A1,CCOC(=O)CSCC1(c2ccc3c(c2)OCO3)OCC(C)(C)CO1>>CC1(C)COC(CSCC(=O)O)(c2ccc3c(c2)OCO3)OC1,,O,,[Li+].[OH-],,val
US20110046147A1,COc1ccc(-c2nc(Br)cs2)cc1.COc1ccc(B(O)O)cc1>>COc1ccc(-c2nc(-c3cccc(OC)c3)cs2)cc1,,CCCCCC,CCOC(C)=O,,,val
US20090298807A1,Cc1ccc(C(=O)N2CCOC3(CCN(Cc4cc(CCO[Si](C)(C)C(C)(C)C)cs4)CC3)C2)s1>>Cc1ccc(C(=O)N2CCOC3(CCN(Cc4cc(CCO)cs4)CC3)C2)s1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20030187026A1,Clc1cnnc2ccc(Br)cc12.Nc1ccccc1>>Brc1ccc2nncc(Nc3ccccc3)c2c1,,CO,,,,val
US20090156593A1,CN(C)C1(c2cccc(F)c2)CCC2(CC1)OCCO2>>CN(C)C1(c2cccc(F)c2)CCC(=O)CC1,,O,,Cl,Cl,val
US04447425,CC(=O)O[C@H]1[C@@H](N2CCCCC2)C[C@H]2[C@@H]3CC[C@H]4CC[C@@H](O)C[C@]4(C)[C@H]3CC[C@@]21C>>CC(=O)O[C@H]1[C@@H](N2CCCCC2)C[C@H]2[C@@H]3CC[C@H]4CCC(=O)C[C@]4(C)[C@H]3CC[C@@]21C,,CC(C)=O,,O=S(=O)(O)O,O=[Cr](=O)=O,val
US20110065699A1,CC1(C)OB(c2ccc(N)nc2)OC1(C)C.COc1cccc(C(=O)CBr)c1>>COc1cccc(-c2cn3cc(B4OC(C)(C)C(C)(C)O4)ccc3n2)c1,,CCCO,,O=C([O-])O.[Na+],,val
US20100105655A1,C1COCCN1.COc1cc(N2CCNCC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>COc1cc(N2CCN(C(=O)N3CCOCC3)CC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20110257151A1,COC(=O)c1ccc2c(c1)CC(C)(C)C(c1cccc(S(=O)(=O)Nc3ccccc3)c1)=N2>>COC(=O)c1ccc2c(c1)CC(C)(C)C(c1cccc(S(=O)(=O)Nc3ccccc3)c1)N2,[Pd],C1CCOC1,CO,,,val
US04221811,CCCC[Mg]Br.CCOCC.C[Sn](Br)(Br)CCCBr>>CCCC[Sn](C)(CCCC)CCCBr,,CCOCC,,[Cl-].[NH4+],,val
US20130072492A1,CC1(C(=O)NC2CC2)C(=O)Nc2nc(-c3nn(CCC(F)(F)C(F)(F)F)c4nc(Cl)ccc34)nc(N)c21.C[Mg]Br>>Cc1ccc2c(-c3nc(N)c4c(n3)NC(=O)C4(C)C(=O)NC3CC3)nn(CCC(F)(F)C(F)(F)F)c2n1,,CN1CCCC1=O,,C1CCOC1,Cl,val
US20130072490A1,Cc1noc(-c2ccc(Br)cc2)c1C(C#C[Si](C)(C)C)NS(C)(=O)=O>>C#CC(NS(C)(=O)=O)c1c(C)noc1-c1ccc(Br)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040102483A1,NNC(=O)CCC(=O)NC1CCN(Cc2ccc(F)c(F)c2)CC1.S=C=Nc1ccccc1Cl>>O=C(CCc1nnc(Nc2ccccc2Cl)o1)NC1CCN(Cc2ccc(F)c(F)c2)CC1,,CN(C)C=O,,,,val
US20120088753A1,O=C(NCCCn1ccc2cnc(Nc3ccc(N4CCOCC4)nc3)nc21)OCc1ccccc1>>NCCCn1ccc2cnc(Nc3ccc(N4CCOCC4)nc3)nc21,[Pd],CCO,,CCOC(C)=O,,val
US20070179167A1,COC(=O)C(O)[C@H](CC1CC1)NC(=O)OCc1ccccc1>>O=C(N[C@@H](CC1CC1)C(O)C(=O)O)OCc1ccccc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20100016396A1,CCc1nn(C)c(Oc2cc(OCc3ccc(OC)cc3)c(Cl)cc2Cl)c1C=O.C[Si](C)(C)C[Mg]Cl>>C=Cc1c(CC)nn(C)c1Oc1cc(O)c(Cl)cc1Cl,,C1CCOC1,,O,O=S(=O)(O)O,val
US04361559,CCCCSC1(SCC)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](OC(C)=O)C[C@@]21C>>CCCCSC1(SCC)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C,,C1CCOC1,CO,,,val
US20030087926A1,CC=Cc1ccc(OC)c(OC)c1.CCC(=O)C(=O)[O-].Nc1cc(Cl)cc(Cl)c1>>CCOC(=O)C1Nc2cc(Cl)cc(Cl)c2C(c2ccc(OC)c(OC)c2)C1C,,CC#N,,O=C(O)C(F)(F)F,,val
US20120232083A1,CC1(C)OB(c2ccc(-n3ncnn3)cc2)OC1(C)C.C[C@@](CCn1cc(F)c(I)cc1=O)(C(=O)NOC1CCCCO1)S(C)(=O)=O>>C[C@@](CCn1cc(F)c(-c2ccc(-n3ncnn3)cc2)cc1=O)(C(=O)NOC1CCCCO1)S(C)(=O)=O,[Pd],C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20040097496A1,CC(=O)N1C=C(c2cc(O)c(O)c(O)c2)N(CC(=O)O)C(=O)C1C(C)C.CC(=O)OC(C)=O.CC(C)=O>>CC(=O)Oc1cc(C2=CN(C(C)=O)C(C(C)C)C(=O)N2CC(=O)O)cc(OC(C)=O)c1OC(C)=O,,CC(C)=O,,,,val
US20030199547A1,COc1cc(-c2cccc(Cl)c2)c2cc(C(=O)c3ccoc3)ccc2n1>>O=C(c1ccoc1)c1ccc2[nH]c(=O)cc(-c3cccc(Cl)c3)c2c1,,C1CCOC1,,Cl,[NH4+].[OH-],val
US04260611,ON=Cc1c(Cl)nc(-c2ccccc2)c2ccccc12>>NCc1c(Cl)nc(-c2ccccc2)c2ccccc12,[Ni],N,,,,val
US20160235716A1,CC(C)(C)OC(=O)CBr.O=C1NC(=O)C2(CCc3cc(N4CCC(O)C4)ccc32)N1>>CC(C)(C)OC(=O)CN1C(=O)NC2(CCc3cc(N4CCC(O)C4)ccc32)C1=O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040039038A1,CNC(=O)c1cc(-c2ccccc2)cc(-c2ccc(C=O)cc2)c1>>CNCc1cc(-c2ccccc2)cc(-c2ccc(CO)cc2)c1,,C1CCOC1,,[H-].[Na+],,val
US20160072082A1,CC(C)c1cc(Br)c(N)c(Br)c1.COc1ccc(B2OC(C)(C)C(C)(C)O2)c(C#N)c1>>COc1ccc2c(c1)c(N)nc1c(Br)cc(C(C)C)cc12,,O,,Cc1ccccc1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US05025025,COC(=O)C(CC=Cc1cccnc1)CCCC#N>>COC(=O)C(CCCCN)CCCc1cccnc1,[Rh],CO,,N,,val
US05331099,O=C(Nc1ccc([N+](=O)[O-])cc1)c1ccccc1>>Nc1ccc([N+](=O)[O-])cc1,,CO,,,,val
US20140349972A1,CC(C)(C)[S@@](=O)/N=C/c1cccc(Br)c1.[Li]c1ccccc1>>CC(C)(C)[S@@](=O)N[C@H](c1ccccc1)c1cccc(Br)c1,,C1CCOC1,,,,val
US20160176858A1,CCOC(=O)C(Cl)C(C)=O.C[C@@H]1CC[C@@H](C(N)=O)CN1C(=O)c1ccccc1-n1nccn1>>CCOC(=O)c1oc([C@@H]2CC[C@@H](C)N(C(=O)c3ccccc3-n3nccn3)C2)nc1C,,CC#N,,,,val
US20110144066A1,CC(=O)Nc1ccc(S(=O)(=O)Nc2nnc(S(N)(=O)=O)s2)cc1>>Nc1ccc(S(=O)(=O)Nc2nnc(S(N)(=O)=O)s2)cc1,,Cl,,,,val
US20120264735A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC(CO)C(F)(F)F>>CC(C)(C)OC(=O)NC(CO)C(F)(F)F,,ClCCl,,,,val
US20090253677A1,CCOC(=O)c1nc2n(c(=O)c1O)C[C@H]1CC[C@@](C)(C2NC(=O)OCc2ccccc2)C1(C)C.NCc1ccc(F)cc1>>CC1(C)[C@@H]2CC[C@@]1(C)[C@@H](NC(=O)OCc1ccccc1)c1nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n1C2,,CCO,CCOCC,CCN(CC)CC,,val
US20150141400A1,CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(CO)c(C(F)(F)F)cc2c1=O.CS(=O)(=O)Cl>>CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(COS(C)(=O)=O)c(C(F)(F)F)cc2c1=O,,ClCCl,,CCN(CC)CC,O,val
US20140263071A1,CCCCCCCCC#N.ClP(Cl)Cl.O=S(=O)(O)c1ccccc1.OP(O)O>>CCCCCCCCC(N)(P(=O)(O)O)P(=O)(O)O,,O,,,,val
US04367235,CC(=O)Nc1cc2c(cc1OC(C)=O)CCC2.O=[N+]([O-])O>>CC(=O)Nc1c(OC(C)=O)cc2c(c1[N+](=O)[O-])CCC2,,CC(=O)OC(C)=O,,,,val
US20090227622A1,CC(C)[Si](C#Cc1ccn2ccnc2c1)(C(C)C)C(C)C>>C#Cc1ccn2ccnc2c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140323468A1,CC(C)(O)c1cncc(-c2cnc3c(c2)CCCN3)c1.O=C=NC(=O)c1ccccc1>>CC(C)(O)c1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20150051395A1,COC(=O)c1c(F)cc(N)cc1F.COc1ccc(Br)cc1S(=O)(=O)Cl>>COc1ccccc1S(=O)(=O)Nc1cc(F)c(C(=O)O)c(F)c1,,ClCCl,,c1ccncc1,,val
US20040097524A1,CCOC(=O)C(=O)OCC.NC(=O)c1sccc1N>>CCOC(=O)c1nc(O)c2sccc2n1,,CCO,,C,C[O-].[Na+],val
US20130079313A1,CS(=O)(=O)Oc1cc(C(=O)OCC(=O)OCc2ccccc2)ccc1OCC1CC1>>CS(=O)(=O)Oc1cc(C(=O)OCC(=O)O)ccc1OCC1CC1,[Pd],CCOC(C)=O,CO,,,val
US05556977,CC(=O)c1cc(Cl)c(O)c(Cl)c1.COC(=O)CBr>>COC(=O)COc1c(Cl)cc(C(C)=O)cc1Cl,,CN(C)C=O,O,CCCCCC,[H-].[Na+],val
US20100292279A1,COC(=O)c1ccc(OCc2ccccc2)c(OCC2CC2)c1>>O=C(O)c1ccc(OCc2ccccc2)c(OCC2CC2)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20040198790A1,C=CCOP(=O)(OCC=C)OCCCC(=O)OCc1ccc(OC)cc1>>C=CCOP(=O)(OCC=C)OCCCC(=O)O,,Cc1ccccc1,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20090291988A1,Brc1ccc(-c2ccccc2)cc1.CC1(C)OB(c2ccc(C3(C#N)CC3)cc2F)OC1(C)C>>N#CC1(c2ccc(-c3ccc(-c4ccccc4)cc3)c(F)c2)CC1,,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US04323644,C=CC(=O)O.O=C1CCC(=O)N1O>>C=CC(=O)ON1C(=O)CCC1=O,,ClC(Cl)Cl,,,,val
US20060183762A1,CC1OC12CCN(C(=O)OCc1ccccc1)C2.F>>CC(O)C1(F)CCN(C(=O)OCc2ccccc2)C1,,ClCCl,,c1ccncc1,,val
US05703096,O=C1SC(Cc2ccc(O)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1.OCCON=Cc1ccccc1>>O=C1SC(Cc2ccc(OCCON=Cc3ccccc3)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040167030A1,CC(Cl)OC(=O)Cl.ClCCCl.O=S(=O)(c1ccccc1)c1c[nH]c2ccc(N3CCN(Cc4ccccc4)CC3)nc12>>Cl.Cl.O=S(=O)(c1ccccc1)c1c[nH]c2ccc(N3CCNCC3)nc12,,ClCCCl,,,,val
US20030109539A1,CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.O=C1NCN(c2ccccc2)C12CCNCC2.O=Cc1cccnc1Br.[Na+]>>O=C([O-])O.O=C1NCN(c2ccccc2)C12CCN(Cc1cccnc1Br)CC2.[Na+],,C1CCOC1,O,,,val
US20080200460A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(OCc1ccccc1)N1CCC(NCC2CC2)CC1>>CC(C)(C)OC(=O)N(CC1CC1)C1CCN(C(=O)OCc2ccccc2)CC1,,ClCCl,,CCN(CC)CC,,val
US06140332,CCOC(=O)c1cc(C(=O)OCC)c(N)[nH]1.NC=O>>CCOC(=O)c1cc2c(O)ncnc2[nH]1,,O=CO,,CN(C)C=O,,val
US20100143341A1,COc1cc(C(=O)Cl)ccc1[N+](=O)[O-].N>>COc1cc(C(N)=O)ccc1[N+](=O)[O-],,C1CCOC1,CCOC(C)=O,C1COCCO1,,val
US20110142796A1,Nc1ncc(Br)c(NC2CCOCC2)n1.OB(O)c1ccncc1Cl>>Nc1ncc(-c2ccncc2Cl)c(NC2CCOCC2)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,,,val
US20090197863A1,CCOC(=O)C1CCC[NH2+]C1.ClCCBr>>CCOC(=O)C1CCCN(CCCl)C1,,CC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US05942630,O=C(O)C1CCN1.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>O=C(O)[C@H]1CCN1.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-],,O,,CCO,,val
US20100130470A1,BrBr.c1cnc2c(c1)CNCCCN2>>Brc1cnc2c(c1)CNCCCN2,,CC(=O)O,ClCCl,,,val
US20100009975A1,CN(CCN1CCSc2cc(NC(=N)c3ccco3)ccc21)C(=O)OC(C)(C)C>>CNCCN1CCSc2cc(NC(=N)c3ccco3)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030078260A1,COC(=O)c1cccc(S(=O)(=O)c2ccc3c(c2)CC[C@H](CN(C[C@H](O)c2cccnc2)C(=O)OC(C)(C)C)O3)c1>>O=C(O)c1cccc(S(=O)(=O)c2ccc3c(c2)CC[C@H](CNC[C@H](O)c2cccnc2)O3)c1,,C1COCCO1,,Cl,,val
US20090247567A1,CN(C)C=C(C(=O)c1cc2c(s1)-c1ccccc1OCC2)c1ccccc1Cl.NN>>Clc1ccccc1-c1c[nH]nc1-c1cc2c(s1)-c1ccccc1OCC2,,CO,,,,val
US20120046283A1,COc1cccc2c1C(=O)CC2.NO>>COc1cccc2c1C(=NO)CC2,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20060229325A1,Clc1ncc(Br)c(Cl)n1.OCCCS>>OCCCSc1nc(Cl)ncc1Br,,CC#N,,CCN(CC)CC,,val
US20090156646A1,CCNC(CC)CC(=O)Nc1cccc(-c2cc(-c3ccc(F)cc3O)nc(NC(=O)c3ccco3)c2C#N)c1.Cl>>CCNC(CC)CC(=O)Nc1cccc(-c2cc(-c3ccc(F)cc3O)nc(NC(=O)c3ccco3)c2C#N)c1.Cl,,CCOC(C)=O,,,,val
US05811432,O=C1Nc2cnccc2C1C(=O)c1cccs1.O=C=NS(=O)(=O)Cl>>NC(=O)N1C(=O)C(C(=O)c2cccs2)c2ccncc21,,CC#N,,,,val
US20120041214A1,CCCCNCCCC.CCOC(=O)CC(C)=O.Cc1ccccc1>>CCOC(=O)C(=CCC(C)C1CC=C(C)CC1)C(C)=O,,CC(=O)O,,,,val
US20110028414A1,COc1ccc(C(=O)CBr)cc1.Oc1ccc(Br)cc1>>COc1ccc(C(=O)COc2ccc(Br)cc2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060217448A1,O=C(CC12CC3CC(CC(C3)C1)C2)Nc1ncnc2c1CCNC2.OCCCBr>>O=C(CC12CC3CC(CC(C3)C1)C2)Nc1ncnc2c1CCN(CCCO)C2,,CCO,,CCN(C(C)C)C(C)C,,val
US20080275038A1,Nc1nc(-c2cccnc2)c(-c2ccncc2F)cc1[N+](=O)[O-]>>Nc1cc(-c2ccncc2F)c(-c2cccnc2)nc1N,[Pd],C1CCOC1,CCO,,,val
US20140200216A1,CC(O)c1ccc2cc(NC(=O)OCc3ccccc3)c(C(=O)Nc3cnccc3N3CCC[C@H](NC(=O)OC(C)(C)C)C3)nc2c1>>CC(O)c1ccc2cc(N)c(C(=O)Nc3cnccc3N3CCC[C@H](N)C3)nc2c1,[Pd],CO,,ClCCl,O=C(O)C(F)(F)F,val
US20030220241A1,CSCC[C@@H](C=O)NC(=O)OC(C)(C)C.Nc1cccc(Cl)c1>>CSCC[C@@H](CNc1cccc(Cl)c1)NC(=O)OC(C)(C)C,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20110237791A1,COc1nc(/C(=C/C(=O)O)c2ccc(C(C)(C)C)cc2)ccc1Cl.O=C1CCC(=O)N1Br>>COc1nc(/C(=C/Br)c2ccc(C(C)(C)C)cc2)ccc1Cl,,CCN(CC)CC,,CC#N,,val
US20070213375A1,Cc1ccccc1C(=O)n1nc(Nc2cccc(O)c2)nc1N.N#CCBr>>Cc1ccccc1C(=O)n1nc(Nc2cccc(OCC#N)c2)nc1N,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100240642A1,CCOC(=O)c1c(-c2ccc(C(C)(C)C)cc2)c2ccccc2n1Cc1cc(OCc2ccccc2)cc(OCC2CC2)c1>>CCOC(=O)c1c(-c2ccc(C(C)(C)C)cc2)c2ccccc2n1Cc1cc(O)cc(OCC2CC2)c1,[Pd],CO,ClC(Cl)Cl,,,val
US20150353532A1,Cc1cc(N2CC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C=N2)ccc1C(=O)OC(C)(C)C>>Cc1cc(N2CC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C=N2)ccc1C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140163002A1,CC(C)(C)[S@](N)=O.O=Cc1ccnc(Cl)c1F>>CC(C)(C)[S@@](=O)/N=C/c1ccnc(Cl)c1F,,CCOC(C)=O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],,val
US03979458,C=CC(=O)OC.CC1C(=O)CCC1=O>>COC(=O)CCC1(C)C(=O)CCC1=O,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20150299189A1,Cn1ccc2cc(Nc3ncc(C4CC4)cc3C(=O)O)cc(/C=C/CO[Si](C)(C)C(C)(C)C)c21>>Cn1ccc2cc(Nc3ncc(C4CC4)cc3C(=O)O)cc(/C=C/CO)c21,,CO,Cl,,,val
US04874775,CS(=O)(=O)Cl.Cc1ccc(NCc2cccnc2)c(C)c1>>Cc1ccc(N(Cc2cccnc2)S(C)(=O)=O)c(C)c1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20050075499A1,COC(=O)c1cc(NC(C)=O)cc([N+](=O)[O-])c1C.COC(OC)N(C)C>>COC(=O)c1cc(NC(C)=O)cc2c1ccn2O,,CN(C)C=O,,,,val
US20080008682A1,CCOP(=O)(OCC)c1cccc(Cn2c(Br)nc3c(N)nc(OCCOC)nc32)c1.CO>>CCOP(=O)(O)c1cccc(Cn2c(O)nc3c(N)nc(OCCOC)nc32)c1,,CO,,[Na+].[OH-],,val
US20140038975A1,CCOC(=O)[C@@](C)(CCn1cc(C2=CCCCC2)cn1)S(C)(=O)=O>>CCOC(=O)[C@@](C)(CCn1cc(C2CCCCC2)cn1)S(C)(=O)=O,[Pd],CO,,,,val
US20120214848A1,CC(C)Oc1ncc(-c2nc(-c3ccc(N[C@H]4CC[C@@H](C(=O)O)C4)cc3)no2)cc1Cl.CCCO>>CC(C)Oc1ncc(-c2nc(-c3ccc(N[C@H]4CC[C@@H](C(=O)O)C4)cc3)no2)cc1Cl.CCCO,,CCCO,,,,val
US20130116243A1,Cc1nc2c([nH]1)CCc1nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc1-2>>Cc1nc2c([nH]1)CCc1nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)cc1-2,,O=C(O)C(F)(F)F,,,,val
US20090118201A1,Cc1ccc(S(=O)(=O)OCCOC2C=CCCC2)cc1.OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O>>OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(OCCOC4C=CCCC4)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20080269208A1,Cc1ccncc1-c1cc(N2C[C@H]3COCCN3C[C@H]2CO[Si](C)(C)C(C)(C)C)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>Cc1ccncc1-c1cc(N2C[C@H]3COCCN3C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CO,,Cl,,val
US20040147588A1,CCOc1cc([C@H](CS(C)(=O)=O)N2Cc3cccc(N)c3C2=O)ccc1OC.O=C(Cl)C1CC1>>CCOc1cc([C@H](CS(C)(=O)=O)N2Cc3cccc(NC(=O)C4CC4)c3C2=O)ccc1OC,,C1CCOC1,,,,val
US20120329785A1,CN1CCN(C2CCN(c3ccc(N)cc3)CC2)CC1.COc1ccc(Cn2cc3c(n2)c(Cl)nc2cccc(F)c23)cc1>>CN1CCN(C2CCN(c3ccc(Nc4nc5cccc(F)c5c5cn[nH]c45)cc3)CC2)CC1,C1COCCO1,CO,,Cl,,val
US20050032786A1,O=c1nc(-c2ccccn2)sc2ccc(O)cc12.OCCCBr>>O=c1nc(-c2ccccn2)sc2ccc(OCCCO)cc12,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110160062A1,COCCOc1c(S(C)(=O)=O)ccc(C(=O)O)c1C.O=C(Cl)C(=O)Cl>>COCCOc1c(S(C)(=O)=O)ccc(C(=O)Cl)c1C,,ClC(Cl)Cl,,CN(C)C=O,,val
US20090275606A1,CC1(C)OCC(CN)O1.O=S(=O)(Cl)Cl>>CC1(C)OCC(CNS(=O)(=O)Cl)O1,CN(C)c1ccncc1,ClCCl,,,,val
US20120238569A1,COC(=O)[C@H](CNC(=O)OC(C)(C)C)NC(=O)c1sc(C(=O)NCc2cccc(O)c2)cc1Br.O=C(O)C(F)(F)F>>COC(=O)[C@H](CN)NC(=O)c1sc(C(=O)NCc2cccc(O)c2)cc1Br.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20140221332A1,CCC(OC)C(=O)O.NC(=NO)c1ccc(C#Cc2cccc(F)c2)cc1>>CCC(OC)c1nc(-c2ccc(C#Cc3cccc(F)c3)cc2)no1,,C1COCCO1,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20140045828A1,COc1cc(F)c2c(c1)C1(CCSC(NC(=O)c3ccccc3)=N1)c1cc(Br)ccc1O2>>COc1cc(F)c2c(c1)C1(CCSC(N)=N1)c1cc(Br)ccc1O2,,CO,O,[Li+].[OH-],,val
US20110015225A1,CC(C)(C)OC(=O)NC1CCNCC1.CS(=O)(=O)Cl>>CS(=O)(=O)N1CCC(N)CC1.Cl,,C1CCOC1,,CCN(CC)CC,CCOC(C)=O,val
US20050070542A1,CC(C)I.Cc1nc2[nH]nc(C)c2nc1Br>>Cc1nc2c(nc1Br)c(C)nn2C(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120135999A1,Cc1cnc2cc[nH]c2c1.O=C=NS(=O)(=O)Cl>>Cc1cnc2c(C#N)c[nH]c2c1,,CC#N,,CN(C)C=O,,val
US20100016337A1,CC(C)(C)OC(=O)CNc1nnc(-c2ccccc2)s1>>O=C(O)CNc1nnc(-c2ccccc2)s1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20140206618A1,Cc1c([C@H]2CN3CCN(C(=O)OC(C)(C)C)C[C@@H]3CO2)ccc(F)c1C#N.Cl>>Cc1c([C@H]2CN3CCNC[C@@H]3CO2)ccc(F)c1C#N.Cl,,CC(C)O,,,,val
US20100168080A1,CN(C)C=O.Clc1ccc(OC2CCNCC2)cc1.O.O=[N+]([O-])c1cc(Cl)ccc1OCCCBr>>COc1cc(OCCCN2CCC(Oc3ccc(Cl)cc3)CC2)c([N+](=O)[O-])cc1Cl,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20030078426A1,Cc1cc(Oc2ccc(N)c(N(C)C(=O)OC(C)(C)C)c2)cc(C)c1NC(=O)OC(C)(C)C.O=C(O)COc1ccc(CC2SC(=O)NC2=O)cc1>>Cc1cc(Oc2ccc(NC(=O)COc3ccc(CC4SC(=O)NC4=O)cc3)c(N(C)C(=O)OC(C)(C)C)c2)cc(C)c1NC(=O)OC(C)(C)C,,C1CCOC1,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20080318935A1,CCOC(C#N)OCC.[C-]#[N+]CC(=O)OC>>CCOC(OCC)c1nc[nH]c1C(=O)OC,,COCCOCCOC,,CCOCC,,val
US20100216814A1,CC(=CBr)c1ccncc1.CN1CCc2[nH]c3ccc(Cl)cc3c2C1>>C/C(=C/n1c2c(c3cc(Cl)ccc31)CN(C)CC2)c1ccncc1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20080045497A1,COC(=O)CBr.O=C(/C=C/c1ccccc1)Nc1ccc(OC(=O)/C=C/c2ccccc2)cc1>>COC(=O)CN(C(=O)/C=C/c1ccccc1)c1ccc(OC(=O)/C=C/c2ccccc2)cc1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20090239854A1,C=Cc1ccc(C(=O)O)nc1.CN1CCc2[nH]c3ccc(CO)cc3c2C1>>CN1CCc2c(c3cc(CO)ccc3n2CCc2ccc(C(=O)O)nc2)C1,,CN1CCCC1=O,,[K+].[OH-],,val
US20130102576A1,CC(C)(C)OC(=O)N(c1cn(CC(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)c2ccccc12)S(C)(=O)=O>>CS(=O)(=O)Nc1cn(CC(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)c2ccccc12,,ClCCl,,C1COCCO1,Cl,val
US20090099185A1,CC(C)C[C@H](NCCCCCOc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3)ccc2=O)c(F)c1)C(=O)OC1CCCC1>>CC(C)C[C@H](NCCCCCOc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3)ccc2=O)c(F)c1)C(=O)O,,C1CCOC1,O,[Li+].[OH-],,val
US06469021B1,CC(=O)c1ccc(C(=O)O)cc1.NNC(=O)c1cc2c3ccccc3n(Cc3cc(Cl)ccc3Cl)c2cn1>>CC(=NNC(=O)c1cc2c3ccccc3n(Cc3cc(Cl)ccc3Cl)c2cn1)c1ccc(C(=O)O)cc1,CC(=O)O,CCOC(C)=O,,CS(C)=O,,val
US20090186886A1,CC(=O)Nc1ccc2c(c1[N+](=O)[O-])CCCC2>>Nc1ccc2c(c1[N+](=O)[O-])CCCC2,,Cl,O,N,,val
US20090181946A1,C=CC[Sn](CCCC)(CCCC)CCCC.Nc1ccc(F)cc1Br>>C=CCc1cc(F)ccc1N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,CN(C)C=O,,val
US07652008B2,COc1cc2c(cc1NS(=O)(=O)CCl)OC(C)(C)[C@H](O)[C@H]2N(CCc1ccccc1)C(=O)OC(C)(C)C>>CC1(C)Oc2cc(NS(=O)(=O)CCl)c(O)cc2[C@H](NCCc2ccccc2)[C@H]1O,,ClCCl,,BrB(Br)Br,O,val
US05391566,COC(=O)Cc1ccc2c(c1)OCO2.O=C1CCC(=O)N1Br>>COC(=O)C(Br)c1ccc2c(c1)OCO2,,ClC(Cl)(Cl)Cl,,,,val
US20080214544A1,C1CCNC1.Cn1c(Nc2ccccc2)ncc(-c2ccc(Oc3ccnc(N)c3)cn2)c1=O.O=C(Cl)Oc1ccccc1>>Cn1c(Nc2ccccc2)ncc(-c2ccc(Oc3ccnc(NC(=O)N4CCCC4)c3)cn2)c1=O,,C1CCOC1,,CCN(CC)CC,,val
US20140142082A1,BrCC1CCCCC1.CC(C)(C)NS(=O)(=O)c1cc[nH]c1>>CC(C)(C)NS(=O)(=O)c1ccn(CC2CCCCC2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05166214,CCCCNC(=O)CCCCCCCSc1nc(-c2ccccc2)c(-c2ccccc2)[nH]1>>CCCCNCCCCCCCCSc1nc(-c2ccccc2)c(-c2ccccc2)[nH]1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050209259A1,CC(C)n1c(CCC(O)CC(O)=CC(=O)[O-])c(-c2ccc(F)cc2)c2ccccc21.[Na+]>>CC(C)n1c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])c(-c2ccc(F)cc2)c2ccccc21.[Na+],,CCO,,,,val
US20100168418A1,FC(F)(F)c1ccc2c(Cl)ccnc2c1.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1ccc(Cl)c2ccc(C(F)(F)F)cc21,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20090005379A1,CC(C)N1CCC(Oc2cnc3[nH]c(C(=O)N4CCC(F)(F)CC4)cc3c2)CC1.CS(=O)(=O)Cl>>CC(C)N1CCC(Oc2cnc3c(c2)cc(C(=O)N2CCC(F)(F)CC2)n3S(C)(=O)=O)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20130225620A1,c1cc(CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)c2cnn(C3CCCCO3)c2c1>>c1cc(CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)c2cn[nH]c2c1,,CO,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100197679A1,COc1ccc2ncc(=O)n(-c3ncc4c(n3)CCC(NC(=O)OC(C)(C)C)C4)c2n1.Cl>>COc1ccc2ncc(=O)n(-c3ncc4c(n3)CCC(N)C4)c2n1.Cl,,ClCCl,,C1COCCO1,,val
US20100197640A1,O=[N+]([O-])c1ccc(I)cc1.Sc1ccc(Br)cc1>>O=[N+]([O-])c1ccc(Sc2ccc(Br)cc2)cc1,,CCO,,O=C([O-])O.[Na+],,val
US20080194535A1,CCOC(OCC)OCC.CO.O=Cc1cc(C(F)(F)F)ccc1Br>>COc1ccc(Br)c(C(OC)OC)c1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20100130495A1,CC(=O)N1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(OS(=O)(=O)C(F)(F)F)c2C1.NC1(CO)CCCC1>>CC(=O)N1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(NC3(CO)CCCC3)c2C1,,CS(C)=O,,,,val
US20120252818A1,CC(=O)Nc1cccc(Sc2cnc(N3CCN(C)CC3)nc2Cl)c1.OCc1cccnc1>>CC(=O)Nc1cccc(Sc2cnc(N3CCN(C)CC3)nc2OCc2cccnc2)c1,,CN(C)C=O,,CO,[H-].[Na+],val
US05583247,CC(=O)C=O.CC(C)(C)c1cccc(C(C)(C)C)c1O>>CC(=O)C=C1C=C(C(C)(C)C)C(=O)C(C(C)(C)C)=C1,,CC(=O)O,Cc1ccccc1,Cl,,val
US04985419,CC(C)CCN.CC(CN1CCC[C@H]1CO)N1c2ccccc2Sc2ccc(C(N)=S)cc21>>CC(C)CCNC(=S)c1ccc2c(c1)N(C(C)CN1CCC[C@H]1CO)c1ccccc1S2,,CCO,,,,val
US20110092531A1,Cc1cc(CBr)ccc1CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.O=CN1CCCCC1>>Cc1cc(C=O)ccc1CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,C1CCOC1,,[Li]C(C)CC,,val
US20050234042A1,C=CCCN(CCc1ccccc1)C(=O)C1CN1C(C)c1cccc2ccccc12>>CC(c1cccc2ccccc12)N1CCC2CCN(CCc3ccccc3)C(=O)C21,,Clc1ccccc1Cl,,,,val
US20040266768A1,O=C(O)N1CCCCC1.O=[N+]([O-])c1cccnc1Cl>>O=C(O)C1CCN(c2ncccc2[N+](=O)[O-])CC1,,O,,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US20020006956A1,CCOC(=O)COc1ccc2c(c1)C[C@H](N(C[C@@H](O)COc1ccccc1)[C@H](C)c1ccccc1)CCC2>>CCOC(=O)COc1ccc2c(c1)C[C@H](NC[C@@H](O)COc1ccccc1)CCC2,[Pd],C1CCOC1,CCO,[H][H],,val
US04237308,CC/C=C\CC1C(O)CCC1CC(=O)OC>>CC/C=C\CC1C(=O)CCC1CC(=O)OC,,ClCCl,,,,val
US05891899,CCOP(=O)(OCC)c1ccc(C(N)(CC2c3ccccc3Oc3ccccc32)C(=O)O)cc1>>NC(CC1c2ccccc2Oc2ccccc21)(C(=O)O)c1ccc(P(=O)(O)O)cc1,,ClCCl,,C[Si](C)(C)I,,val
US20100041693A1,COC(=O)Cc1coc2ccc(CN(C)C)cc12.N>>CN(C)Cc1ccc2occ(CC(N)=O)c2c1,,CO,,,,val
US20080108638A1,CC(C)(C)OC(=O)Cn1c(Cl)nc2ccccc21.NC(N)=S>>CC(C)(C)OC(=O)Cn1c(S)nc2ccccc21,,CO,,,,val
US20120178774A1,Cc1cc(C)[nH]n1.ClCc1ccccc1Cl>>Cc1cc(C)n(Cc2ccccc2Cl)n1,,CS(C)=O,,O,[K+].[OH-],val
US20130252941A1,[N-]=[N+]=Nc1ccncc1/C=N/c1c(Cl)cc(F)cc1Cl>>Fc1cc(Cl)c(-n2cc3cnccc3n2)c(Cl)c1,,Cc1ccccc1,,,,val
US20160083400A1,Cc1cnc(CC(N)CCO[Si](C)(C)C(C)(C)C)nc1.O=c1[nH]c(Cl)nc2c1cnn2C1CCCC1>>Cc1cnc(CC(CCO[Si](C)(C)C(C)(C)C)Nc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)nc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US05624937,Clc1cc(-c2ccccc2)c2ccccc2n1.Nc1ccc(S)cc1>>Nc1ccc(Sc2cc(-c3ccccc3)c3ccccc3n2)cc1,CN(C)c1ccncc1,CCO,,C1CCOC1,,val
US20120238606A1,CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1.C[N+](C)(C)CCO>>CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1.C[N+](C)(C)CCO,,CCO,,,,val
US20070238775A1,CNCc1ccccc1.O=C(Cl)C(=O)c1c[nH]c2ccccc12>>CN(Cc1ccccc1)C(=O)C(=O)c1c[nH]c2ccccc12,,CC#N,,,,val
US20050208582A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.Fc1cc2[nH]nc(I)c2cc1Br>>Fc1cc2c(cc1Br)c(I)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20120088763A1,CC(C)C(=O)NNc1ccc(F)cn1>>CC(C)c1nnc2ccc(F)cn12,,C1CCOC1,,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110034493A1,O=C(Nc1nc(=O)[nH]cc1F)c1ccc(Cl)cc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=C(Nc1nc(=O)n(S(=O)(=O)c2ccc(Cl)cc2)cc1F)c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20060052445A1,C1COCCN1.O=Cc1cccc(S(=O)(=O)c2ccc(/C=C/c3ccc(F)cc3F)nc2)c1>>O=S(=O)(c1ccc(/C=C/c2ccc(F)cc2F)nc1)c1cccc(CN2CCOCC2)c1,,CC(=O)O,CO,[Na+].[OH-],,val
US20050250949A1,CC(=O)Oc1cccc(C(=O)N[C@@H](CSc2ccccc2)[C@H](O)CN2C[C@H]3CCCC[C@H]3C[C@H]2C(=O)NC(C)(C)C)c1C>>Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C,,CO,,N,,val
US20050272740A1,COC(=O)CS(=O)(=O)c1ccc2[nH]c(-c3ccc(Cl)s3)nc2c1>>O=C(O)CS(=O)(=O)c1ccc2[nH]c(-c3ccc(Cl)s3)nc2c1,,CO,,[Na+].[OH-],,val
US05272129,COC(=O)c1cccc(OC)c1OS(=O)(=O)N=C=O.COc1cc(OC)nc(N)n1>>COC(=O)c1cccc(OC)c1OS(=O)(=O)NC(=O)Nc1nc(OC)cc(OC)n1,,ClCCl,,,,val
US20100267712A1,CCOC(=O)c1cc([N+](=O)[O-])ccc1CBr.Nc1ccc2ccsc2c1>>O=C1c2cc([N+](=O)[O-])ccc2CN1c1ccc2ccsc2c1,,CCO,,CCN(C(C)C)C(C)C,,val
US05958646,C=Cc1ccc(S(N)(=O)=O)cc1.Cc1cc(C)c(S(=O)(=O)Cl)c(C)c1>>C=Cc1ccc(S(=O)(=O)NS(=O)(=O)c2c(C)cc(C)cc2C)cc1,CN(C)c1ccncc1,CC#N,,CCN(CC)CC,,val
US04990508,CCOC(=O)c1cn2c3c(c(C4(NC(=O)OCc5ccccc5)CC4)c(F)cc3c1=O)OCC2COC1CCCCO1>>CCOC(=O)c1cn2c3c(c(C4(NC(=O)OCc5ccccc5)CC4)c(F)cc3c1=O)OCC2CO,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20150336962A1,C1COCCN1.O=C(Nc1cn(C/C=C/CCl)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12>>O=C(Nc1cn(C/C=C/CN2CCOCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12,,CN(C)C=O,,,,val
US20130035484A1,COc1ccc(COc2ccc(C=O)cc2OCc2ccc(Cl)cc2)cc1>>O=Cc1ccc(O)c(OCc2ccc(Cl)cc2)c1,,CC(=O)O,,,,val
US20030032663A1,CCCN.CCN(CC)CCCOc1ccc([N+](=O)[O-])c(F)c1>>CCCNc1cc(OCCCN(CC)CC)ccc1[N+](=O)[O-],,C1CCOC1,,,,val
US20150274740A1,CCOC(=O)CC(=O)c1ccc2[nH]nnc2c1.Cc1ccccc1-c1n[nH]c(N)n1>>Cc1ccccc1-c1nc2[nH]c(-c3ccc4nn[nH]c4c3)cc(=O)n2n1,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05891889,Cc1cccc(CC2(C(=O)OCc3ccccc3)CCN(C(=O)OC(C)(C)C)CC2)c1>>Cc1cccc(CC2(C(=O)O)CCN(C(=O)OC(C)(C)C)CC2)c1,[Pd],CO,,CC(=O)O,,val
US20030096826A1,CON(C)C(=O)C(CC(=O)OC(C)(C)C)NS(=O)(=O)c1ccc(C(N)=O)cc1O.OCCc1cccc2ncccc12>>CON(C)C(=O)C(CC(=O)OC(C)(C)C)NS(=O)(=O)c1ccc(C(N)=O)cc1OCCc1cccc2ncccc12,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06458814B1,CCOC(=O)CC(Cc1nc(CBr)co1)c1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)CC(Cc1nc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)co1)c1ccccc1.[Br-],,CC#N,,,,val
US20060111347A1,O=C1CCCO1.Sc1ccc2ccccc2c1>>O=C(O)CCCSc1ccc2ccccc2c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20160115128A1,CC(C)(C)CN.CCOC(=O)CC(c1cccc(OCC2CCN(c3cc(OC)ccc3C(=O)O)CC2)c1)C1CC1>>CCOC(=O)CC(c1cccc(OCC2CCN(c3cc(OC)ccc3C(=O)NCC(C)(C)C)CC2)c1)C1CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030004181A1,COCc1nc2cc(C(=O)OC)cnc2s1>>COCc1nc2cc(C(=O)O)cnc2s1,,CCO,,Cl,[Na+].[OH-],val
US20110237791A1,COc1nc(/C(=C/[C@H]2CCC(=O)N2C)c2ccc(C(C)(C)C)cc2)ccc1Cl>>CN1C(=O)CC[C@@H]1/C=C(\c1ccc(C(C)(C)C)cc1)c1ccc(Cl)c(=O)[nH]1,,C1COCCO1,,Br,O,val
US20120172599A1,CC1=C(C#N)C(=C(C#N)C#N)OC1(C)C.CCCCN(CCCC)c1ccc(C=Cc2ccc(C=O)s2)cc1>>CCCCN(CCCC)c1ccc(C=Cc2ccc(C=CC3=C(C#N)C(=C(C#N)C#N)OC3(C)C)s2)cc1,,C1CCOC1,CCO,C,O=C[O-].[NH4+],val
US20050032786A1,CC(C)(C)OC(=O)CCc1ccnc(C#N)c1.O=C(O)c1ccc(Br)cc1S>>CC(C)(C)OC(=O)CCc1ccnc(-c2nc(=O)c3ccc(Br)cc3s2)c1,,c1ccncc1,,,,val
US20070191340A1,C1=CC2OC2(CC2CO2)C=C1.NCCO>>CC(C)C(O)CNCCO,,O,,,,val
US20140349989A1,CC(C)(C)OC(=O)N1CCC(n2cc(C#CCCCN)c3ccccc32)CC1.NCc1cccnc1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)N1CCC(n2cc(C#CCCCNC(=O)NCc3cccnc3)c3ccccc32)CC1,,C1CCOC1,,,,val
US20120165318A1,COC(=O)c1ccc2nc(-c3ccccc3)c(Br)nc2c1.Clc1cccc(N2CCNCC2)c1>>COC(=O)c1ccc2nc(-c3ccccc3)c(N3CCN(c4cccc(Cl)c4)CC3)nc2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04698093,CC1CN1.CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)Cl)c(C(=O)OC)c1Cl>>CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)Cl)c(C(=O)OC)c1N1CC1C,,CN(C)C=O,O,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US04360680,C=C(C)C#N.NNc1ccccc1>>CC1CN(c2ccccc2)N=C1N,,CCO,,[Na],,val
US20080207654A1,CCCCc1nc(CC)cc(=O)[nH]1.N#Cc1ccccc1-c1ccc(CBr)cc1>>CCCCc1nc(CC)cc(=O)n1Cc1ccc(-c2ccccc2C#N)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060166992A1,C1COCCN1.COc1cc(Nc2nc(-c3ccc(Cl)nc3)nn3c(C)nc(C)c23)cc(OC)c1OC>>COc1cc(Nc2nc(-c3ccc(N4CCOCC4)nc3)nn3c(C)nc(C)c23)cc(OC)c1OC,,O,,O=C([O-])[O-].[K+].[K+],,val
US20060128793A1,COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CC[C@H](O)[C@@]2(C)C[C@H]1OC(C)=O.c1ccc(N2CCNCC2)cc1>>COC[C@H]1OC(=O)/C(=C/N2CCN(c3ccccc3)CC2)C2=C(O)C(=O)C3=C([C@H](OC(C)=O)C[C@@]4(C)C3CC[C@@H]4O)[C@]21C,,ClCCl,,,,val
US20080280875A1,CCOC(OCC)OCC.COC(=O)c1cc(N)c(O)c(O)c1>>COC(=O)c1cc(O)c2ocnc2c1,,CCCCCC,,Cl,,val
US20080312226A1,Cn1nccc1NC(=O)OCC(Cl)(Cl)Cl.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>Cn1nccc1NC(=O)N1CCN(c2nc(-c3ccccc3)ns2)CC1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US20160096839A1,C=CC[C@H](NC(=O)OC(C)(C)C)c1ccnc(-c2c([N+](=O)[O-])cnn2C(F)F)c1>>C=CC[C@H](NC(=O)OC(C)(C)C)c1ccnc(-c2c(N)cnn2C(F)F)c1,[Zn],CC(C)=O,O,[Cl-].[NH4+],,val
US20020013460A1,CCN1CCN(c2nc(-c3ccc(O)cc3)cc3ccccc23)CC1.COCCBr>>CCN1CCN(c2nc(-c3ccc(OCCOC)cc3)cc3ccccc23)CC1,,CN(C)C=O,,[H][H],[H-].[Na+],val
US04057418,CNC(=O)c1cc(Cl)cc(N)c1Cl.O=S(=O)(CO)c1ccc(Cl)cc1>>CNC(=O)c1cc(Cl)cc(NCS(=O)(=O)c2ccc(Cl)cc2)c1Cl,,O,,O=S(=O)(O)O,,val
US20080085905A1,COC(=O)c1cnc(N2CCCCC2)cn1.O=C1CCC(=O)N1Br>>COC(=O)c1cnc(N2CCCCC2)c(Br)n1,,ClC(Cl)Cl,,,,val
US20060257987A1,CCOC(=O)C(C)(C)Oc1ccc(OCCC(C)Oc2ccc(CC)cc2C(=O)c2ccccc2)cc1C>>CCc1ccc(OC(C)CCOc2ccc(OC(C)(C)C(=O)O)c(C)c2)c(C(=O)c2ccccc2)c1,,CCO,,Cl,[Na+].[OH-],val
US20130252934A1,Fc1cc(Br)ccn1.NC1CCOCC1>>Brc1ccnc(NC2CCOCC2)c1,,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140349989A1,O=C(NCc1cccnc1)Nc1ccc(-n2nc(C(=O)O)c3ccccc32)cc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Nc1nn(-c2ccc(NC(=O)NCc3cccnc3)cc2)c2ccccc12,,CN(C)C=O,,CCN(CC)CC,O,val
US20020165235A1,O=C(Nc1cccc2[nH]oc(=O)c12)OCc1cc2cc(-c3ccc(F)cc3)ccc2o1>>Nc1cccc(NC(=O)OCc2cc3cc(-c4ccc(F)cc4)ccc3o2)c1C(=O)O,[Zn],O=S(=O)(O)O,,,,val
US20090137595A1,CNC(=O)c1cn2nc(Oc3cccc(N)c3)ccc2n1.Cc1cc(C(=O)Cl)n(C)n1>>CNC(=O)c1cn2nc(Oc3cccc(NC(=O)c4cc(C)nn4C)c3)ccc2n1,,CC(=O)N(C)C,,O,,val
US04497812,CCN(CC)CC1CO1.N#CN>>CCN(CC)CC1CN=C(N)O1,,CO,,[Na],,val
US20050282808A1,CCOC(=O)c1ccncc1.Clc1ccncc1>>O=C(O)C1CCN(c2ccncc2)CC1,,CCO,O,CCN(CC)CC,Cl,val
US20160200725A1,COC(=O)Cc1cc(OC)cc(OC)c1F.CSc1ncc(C=O)c(N)n1>>COc1cc(OC)c(F)c(-c2cc3cnc(SC)nc3[nH]c2=O)c1,,CN1CCCC1=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100249119A1,CC(C)(C#N)c1cccc(C(=O)Nc2cccc(Nc3ncc4nc(N)sc4n3)c2)c1.O=C(Cl)C1CC1>>CC(C)(C#N)c1cccc(C(=O)Nc2cccc(Nc3ncc4nc(NC(=O)C5CC5)sc4n3)c2)c1,,c1ccncc1,,O=C([O-])O.[Na+],,val
US04956382,CCN(CCc1ccc(NS(C)(=O)=O)cc1)Cc1ccccc1>>CCNCCc1ccc(NS(C)(=O)=O)cc1,[Pd],CCO,,,,val
US20160068559A1,CCN(CCCNc1nc2cc(C(C)(C)C)ccc2[nH]1)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21>>CCN(CCCNc1nc2cc(C(C)(C)C)ccc2[nH]1)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,,O,,O=C(O)C(F)(F)F,,val
US06326359B1,CC(C)Oc1ccc(C=O)cc1.COC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CN)nc32)[C@H](O)[C@@H]1O>>COC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CNCc4ccc(OC(C)C)cc4)nc32)[C@H](O)[C@@H]1O,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040034005A1,BrC(Br)(Br)Br.O=[N+]([O-])c1cccc(Cl)c1CCO>>O=[N+]([O-])c1cccc(Cl)c1CCBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050288314A1,N#Cc1c(F)cccc1F.OCc1ccccc1Br>>N#Cc1c(F)cccc1OCc1ccccc1Br,,CN(C)C=O,,[H-].[Na+],,val
US20140155415A1,CC(C)c1ccccc1[Mg]Br.O=S(=O)(N=Cc1cc2ccccc2o1)c1ccc2c(c1)OCCCO2>>CC(C)c1ccccc1C(NS(=O)(=O)c1ccc2c(c1)OCCCO2)c1cc2ccccc2o1,,CO,,C1CCOC1,,val
US20040235822A1,ClCc1ccncc1.Nc1ccc(S)cc1>>Nc1ccc(SCc2ccncc2)cc1,,CO,,Cl,[Na+].[OH-],val
US20100216795A1,CC(C)(C)OC(=O)Nc1ccc(N)cc1.S=C(Cl)Cl>>CC(C)(C)OC(=O)Nc1ccc(N=C=S)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20100311747A1,CN(C)C(=O)N1CC2CC(Cc3ccccc3)(NCC(=O)N3C[C@@H](F)C[C@H]3C#N)CC2C1.O=C(O)C(O)C(O)C(=O)O>>CN(C)C(=O)N1CC2CC(Cc3ccccc3)(NCC(=O)N3C[C@@H](F)C[C@H]3C#N)CC2C1.O=C(O)C(O)C(O)C(=O)O,,CC(C)=O,ClCCl,,,val
US20060252931A1,Cc1cccc(C(F)(F)F)c1[N+](=O)[O-]>>Cc1cccc(C(F)(F)F)c1N,[Pd],CO,,[H][H],,val
US20050054626A1,CC(C)[C@H](O)[C@@H]1C[C@H](NC(=O)OC(C)(C)C)CC[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1>>CC(C)[C@H](O)[C@@H]1C[C@H](N)CC[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100029737A1,COC(=O)c1cc2c([nH]1)CCC2Cc1cccc(-c2ccc(CO)cc2)c1>>O=C(O)c1cc2c([nH]1)CCC2Cc1cccc(-c2ccc(CO)cc2)c1,,C1CCOC1,,CO,[Li+].[OH-],val
US20140249134A1,COc1ccc(CC(=O)/N=C(/C)N(C)C)cc1OC.Cc1nc(Cl)cc(NN)n1>>COc1ccc(Cc2ncnn2-c2cc(Cl)nc(C)n2)cc1OC,,CC(=O)O,,,,val
US20110028445A1,CC1(C)[C@H]2Cc3c(OS(=O)(=O)C(F)(F)F)cccc3[C@]1(C)CCN2Cc1ccccc1>>CC1(C)[C@H]2Cc3ccccc3[C@]1(C)CCN2,[Pd],CCO,,,,val
US20150018546A1,CCOC(=O)c1cc2c(Cl)ncnc2n(OCc2ccccc2)c1=O.NCc1ccccc1>>CCOC(=O)c1cc2c(NCc3ccccc3)ncnc2n(OCc2ccccc2)c1=O,,C1COCCO1,O,CCN(CC)CC,CCOC(C)=O,val
US04562189,CCOC(=O)N1CCNCC1.COc1cccc(CCl)c1>>COc1cccc(CN2CCN(C(=O)O)CC2)c1,,CC(C)O,,[Na+].[OH-],,val
US20070112073A1,CNCCCC1c2ccccc2C=Cc2ccccc21.Cl>>CNCCCC1c2ccccc2C=Cc2ccccc21.Cl,,CC(C)=O,,,,val
US20040082607A1,CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2cccs2)c2cc(C(N)=O)ccc2c1=O.Cl>>CC(C)Cn1c(CN)c(-c2cccs2)c2cc(C(N)=O)ccc2c1=O.Cl,,CCOC(C)=O,,,,val
US04067725,ClCl.Oc1cccnc1Cl>>Oc1ccc(Cl)nc1Cl,,CN(C)C=O,,,,val
US20050038016A1,CN.CSCOc1cccc(C=O)c1>>CN=Cc1cccc(OCSC)c1,,CCO,,,,val
US20050148624A1,CCC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(S(=O)(=O)CCCOC2CCCCO2)cc1>>CCC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(S(=O)(=O)CCCO)cc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20160046597A1,O=C1NCCO1.O=S(=O)(Cl)Cl>>O=C1OCCN1S(=O)(=O)Cl,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US05576321,ClCCCOc1cccc2[nH]ccc12.Clc1cccc2c(C3=CCNCC3)c[nH]c12>>Clc1cccc2c(C3=CCN(CCCOc4cccc5[nH]ccc45)CC3)c[nH]c12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040254181A1,COC(=O)N=C(NC(=O)OC)SC.COC(=O)c1[nH]cc(Cc2ccsc2)c1N>>COC(=O)NC(=N)N(C(=O)OC)c1c(Cc2ccsc2)c[nH]c1C(=O)OC,,CN(C)C=O,,CCN(CC)CC,,val
US20110046397A1,C=C(C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)[O-].[K+]>>C[C@H](C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)[O-].[K+],[Pd],CCO,,[H][H],,val
US04212828,CCO.COc1ccc(OC)c(CCCC(=O)O)c1>>CCOC(=O)CCCc1cc(OC)ccc1OC,O=S(=O)(O)O,,,O=C([O-])O.[Na+],,val
US20150051133A1,C=C(C)[Mg]Br.O=CC1CC2CCC1C2>>C=C(C)C(O)C1CC2CCC1C2,,C1CCOC1,,[Cl-].[NH4+],,val
US20160083387A1,C=C1CC[C@H]2[C@H](CN)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@]12C.CCN=C=O>>C=C1CC[C@H]2[C@H](CNC(=O)NCC)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@]12C,,C1CCOC1,,,,val
US20160115158A1,COC(=O)c1cccc(S(=O)(=O)Nc2cncc(Cl)c2O)c1>>O=C(O)c1cccc(S(=O)(=O)Nc2cncc(Cl)c2O)c1,,CCO,,[Na+].[OH-],,val
US20090143355A1,N#Cc1ccc(F)cn1>>NCc1ccc(F)cn1,[Pd],CO,Cl,,,val
US20070213336A1,CCOC(=O)/C=C/c1ccc(-c2cccc(NC)c2)cc1>>CCOC(=O)CCc1ccc(-c2cccc(NC)c2)cc1,[Pd],CO,,,,val
US20090176823A1,CCOC(=O)C1=C(c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)nc2)C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]1N2C(=O)OC(C)(C)C(Cl)(Cl)Cl>>Cc1cc(Cl)c(OCCOc2ccc(C3=C(C(=O)O)[C@H]4CN(C(=O)OC(C)(C)C)C[C@@H](C3)N4C(=O)OC(C)(C)C(Cl)(Cl)Cl)cn2)c(Cl)c1,,CCO,,[Na+].[OH-],,val
US20130190293A1,COc1ccc(Br)cn1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>COc1ccc(-n2c3c(c4cc(C)ccc42)CN(C)CC3)cn1,[Cu]I,CN(C)C=O,O,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US05998433,CN(C)Cc1cc2c(o1)CN(C(=O)CCCCCc1ccc(Cl)cc1)CC2.Cl>>CN(C)Cc1cc2c(o1)CN(C(=O)CCCCCc1ccc(Cl)cc1)CC2.Cl,,CCOC(C)=O,CO,,,val
US05719303,NCc1ccc2c(c1)OCO2.O=[N+]([O-])c1ccc2c(Cl)nnc(Cl)c2c1>>O=[N+]([O-])c1ccc2c(Cl)nnc(NCc3ccc4c(c3)OCO4)c2c1,,CCO,,CCN(CC)CC,,val
US20050124673A1,CCOC(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(OC(C)=O)c1C>>Cc1c(O)cccc1C(=O)N[C@@H](Cc1ccccc1)[C@H](O)C(=O)O,,C1CCOC1,,[Na+].[OH-],,val
US20070021442A1,Nc1ccc(S(N)(=O)=O)cc1Cl.O=C(Br)CBr>>NS(=O)(=O)c1ccc(NC(=O)CBr)c(Cl)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US20090048259A1,Clc1nnc(Cl)c2ccccc12.O=C1CNCCN1Cc1ccccc1>>O=C1CN(c2nnc(Cl)c3ccccc23)CCN1Cc1ccccc1,,CCOC(C)=O,,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US20150057271A1,COc1ccc(CNc2ncns2)c(OC)c1.O=[N+]([O-])c1cc(S(=O)(=O)Cl)ccc1F>>COc1ccc(CN(c2ncns2)S(=O)(=O)c2ccc(F)c([N+](=O)[O-])c2)c(OC)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120184553A1,C1COCCN1.O=Cc1ccc(OCc2ccc(F)c(F)c2)c(C(=O)Nc2ccnnc2)c1>>O=C(Nc1ccnnc1)c1cc(CN2CCOCC2)ccc1OCc1ccc(F)c(F)c1,,ClCCCl,ClCCl,CC(=O)O,O=C([O-])O.[Na+],val
US20100179139A1,Cc1nc(Cl)sc1S(=O)(=O)NC1CCS(=O)(=O)CC1.OB(O)c1ccnc2[nH]c(C(F)(F)F)cc12>>Cc1nc(-c2ccnc3[nH]c(C(F)(F)F)cc23)sc1S(=O)(=O)NC1CCS(=O)(=O)CC1,,CC(C)O,,O=C([O-])O.[Na+],,val
US20160083376A1,Cn1c(=O)c(F)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)nc(-c3cccc([N+](=O)[O-])c3)c21>>Cn1c(=O)c(F)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)nc(-c3cccc(N)c3)c21,,C1CCOC1,CCO,,,val
US05741788,C1=c2ccncc2=C2NSN=C2S1.CI>>CN1C=CC2=CSc3ns[nH+]c3C2=C1.[I-],,CC(C)=O,,,,val
US20010051722A1,CC(=O)NC[C@H]1CN(c2ccc(N3CCN(S(C)(=O)=O)CC3)c(F)c2)C(=O)O1.OO>>CC(=O)[NH+]([O-])C[C@@H]1CN(c2ccc(N3CCN(S(C)(=O)=O)CC3)c(F)c2)C(=O)O1,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20040167123A1,CS(=O)(=O)Cl.NCc1csc2c1S(=O)(=O)N=C(c1c(O)c3ccccc3n(NCC3CC3)c1=O)N2>>CS(=O)(=O)NCc1csc2c1S(=O)(=O)N=C(c1c(O)c3ccccc3n(NCC3CC3)c1=O)N2,,CN(C)C=O,,CCN(CC)CC,,val
US04769366,O=C1C=CC2(C=C1)N=C(N1CCN(Cc3ccccc3)CC1)C=C2c1ccccc1>>O=c1ccc2c(-c3ccccc3)cc(N3CCN(Cc4ccccc4)CC3)n2cc1,,ClCCl,,,,val
US04405552,Nc1ccc(-c2ccc(Cl)cc2)c(Cl)n1.O=C=NC(=O)c1c(F)cccc1F>>O=C(NC(=O)c1c(F)cccc1F)Nc1ccc(-c2ccc(Cl)cc2)c(Cl)n1,,CC#N,,,,val
US20120142677A1,CC(C)(C)OC(=O)[C@@H]1CCC(=O)N1.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)[C@@H]1CCC(=O)N1c1ccc([N+](=O)[O-])cc1,,CS(C)=O,,[H-].[Na+],[Cl-].[NH4+],val
US20040053999A1,CCN(CC)CC.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>c1ccc(C(c2ccccc2)(c2ccccc2)N2CC2)cc1,,ClCCl,,CS(=O)(=O)Cl,,val
US06156758,COC(=O)c1ccc(NC2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)CC2)nc1>>COc1cc2nc(N3CCC(Nc4ccc(C(=O)O)cn4)CC3)nc(N)c2cc1OC,,CO,O,[K+].[OH-],,val
US20030065018A1,COc1cccc(C(=O)c2ccc(OC)cc2S)c1.N#CCC#N>>COc1cccc(-c2c(C#N)c(=N)sc3cc(OC)ccc23)c1,,CCO,,C1CCNCC1,,val
US20090163552A1,COC(=O)C(Br)CCBr.O=[N+]([O-])c1ccc(O)cc1F>>COC(=O)C(CCBr)Oc1ccc([N+](=O)[O-])c(F)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US06187393B1,CCC/C=C/CO.CCCCCC12CCC(c3ccc(O)cc3)(CC1)CC2>>CCC/C=C/COc1ccc(C23CCC(CCCCC)(CC2)CC3)cc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05132303,CCCN1C(=O)OC2(CCN(CC=C(c3ccccc3)c3ccccc3)CC2)C1(C)O>>C=C1N(CCC)C(=O)OC12CCN(CC=C(c1ccccc1)c1ccccc1)CC2,,CC(=O)O,CC(=O)OC(C)=O,,,val
US20150291514A1,CC(C)(F)COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1Cl.OO>>CC(C)(F)COc1ncc(O)cc1Cl,,CO,O,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20160039838A1,CCOP(=O)(OCC)C(F)C(=O)O.Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1>>CCOP(=O)(OCC)C(F)C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120283238A1,CC(C)c1cc2c(OC3CCC(N)CC3)ncnc2s1>>CC(C)c1cc2c(OC3CCC(N)CC3)ncnc2s1,,O=CO,,Cl,,val
US20010034352A1,CC(C)(C)OC(=O)NC1CCN(CC(F)Cc2coc3ccccc23)CC1>>NC1CCN(CC(F)Cc2coc3ccccc23)CC1,,CCO,,Cl,,val
US20120157434A1,CC(=O)NC[C@@H]1OC(=O)N2c3ccc(N)cc3C[C@@H]12.Cn1cc(CBr)c(CBr)n1>>CC(=O)NC[C@@H]1OC(=O)N2c3ccc(N4Cc5cn(C)nc5C4)cc3C[C@@H]12,,ClCCl,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04642310,CCOC(=O)C1=C(C)NC(CSC(C)=O)=C(C(=O)OCC)C1c1ccccc1C(F)(F)F>>CCOC(=O)C1=C(C)NC2=C(C(=O)SC2)C1c1ccccc1C(F)(F)F,,CCO,,Cl,,val
US20110118230A1,COC(=O)c1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCCCC4)cc3)cc12.N>>NC(=O)c1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCCCC4)cc3)cc12,,CO,,,,val
US20110039822A1,O=c1[nH]c2cnc(NCc3ccccc3)c([N+](=O)[O-])c2n1C1C2CC3CC1CC(O)(C3)C2>>Nc1ncc2[nH]c(=O)n(C3C4CC5CC3CC(O)(C5)C4)c2c1N,[Pd],CO,,O=C[O-].[NH4+],,val
US20070099930A1,NCc1ccc(F)cc1.O=C1NC(=O)c2c(Cl)cccc21>>O=C1c2cccc(Cl)c2C(=O)N1Cc1ccc(F)cc1,,CC(=O)O,,,,val
US04983607,COc1ccc2cccc(N3CCNCC3)c2c1.O=C1CC(CCCl)c2ccccc2N1>>COc1ccc2cccc(N3CCN(CCC4CC(=O)Nc5ccccc54)CC3)c2c1,,ClCCl,,[Na+].[OH-],,val
US20070093488A1,CC(C)(C)OC(=O)Nc1nc2ccc(OS(=O)(=O)c3cccs3)cc2s1>>Nc1nc2ccc(OS(=O)(=O)c3cccs3)cc2s1,,ClCCl,O,O=C(O)C(F)(F)F,,val
US20130158009A1,CS(=O)(=O)c1ccc(N[C@H]2CCN(C3CCN(c4ncc(C(=O)O)cc4Cl)CC3)C2=O)c(F)c1.O=S(Cl)Cl>>CS(=O)(=O)c1ccc(N[C@H]2CCN(C3CCN(c4ncc(C(=O)Cl)cc4Cl)CC3)C2=O)c(F)c1,CN(C)C=O,ClCCl,,,,val
US20070232627A1,Nc1ccc(Cl)cn1.O=C(Cl)c1ccc(Cl)c([N+](=O)[O-])c1>>O=C(Nc1ccc(Cl)cn1)c1ccc(Cl)c([N+](=O)[O-])c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100093694A1,CCOC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cccc(C(=O)OC(C)(C)C)c3)cc12>>CCOC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cccc(C(=O)O)c3)cc12,,ClCCCl,,O=C(O)C(F)(F)F,,val
US04691027,CC(=O)OC(C)=O.COCOCCCC1Oc2c(C)c(C)c(O)c(C)c2S1>>COCOCCCC1Oc2c(C)c(C)c(OC(C)=O)c(C)c2S1,,c1ccncc1,,c1ccccc1,,val
US20110046147A1,COc1ccc(-c2nsc(-c3ccc(OC)cc3)n2)cc1>>Oc1ccc(-c2nsc(-c3ccc(O)cc3)n2)cc1,,CCCCCC,CCOC(C)=O,,,val
US20160060282A1,NCc1ccccc1.O=C1CCc2ccccc21>>c1ccc(CNC2CCc3ccccc32)cc1,,CO,,O=CO,,val
US20150011773A1,BrCc1ccc(OCc2ccccc2)cc1.CC(C)(C)OC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@@H](C[C@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20150031674A1,Cc1cncc(-c2ccc(-c3cc4cnc(N)nc4n(CC4OCC(NC(=O)OC(C)(C)C)CO4)c3=O)c(Cl)c2)n1>>Cc1cncc(-c2ccc(-c3cc4cnc(N)nc4n(CC4OCC(N)CO4)c3=O)c(Cl)c2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100069431A1,COC(=O)Cc1ccc2nc(-c3cc(OCc4ccccc4)ccc3OC(C)C)[nH]c2n1>>CC(C)Oc1ccc(OCc2ccccc2)cc1-c1nc2ccc(CC(=O)O)nc2[nH]1,,CO,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US20060252767A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(Cl)c1ccccc1C(F)(F)F>>O=C(c1ccccc1C(F)(F)F)N1CCNCC1,,ClCCl,,CCN(CC)CC,,val
US20160200674A1,Cc1ccc(NC(=O)Nc2cc(Br)ccc2N(C2CC2)C2CC2)cc1.O=C(O)c1ccc(F)cc1B(O)O>>Cc1ccc(NC(=O)Nc2cc(-c3cc(F)ccc3C(=O)O)ccc2N(C2CC2)C2CC2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160221945A1,CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)c(C(N)=O)cn1>>CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)c(C#N)cn1,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US04515948,CCI.CCOC(=O)Nc1c(OC)cc(Cc2cnc(N)nc2N)cc1OC>>CCOC(=O)N(CC)c1c(OC)cc(Cc2cnc(N)nc2N)cc1OC,,CN(C)C=O,,[H-].[Na+],,val
US20030139418A1,COC(=O)c1ccc(CCc2ccccc2CCc2ccccc2)cc1O>>O=C(O)c1ccc(CCc2ccccc2CCc2ccccc2)cc1O,,C1CCOC1,CO,[Na+].[OH-],,val
US20120225854A1,O=[N+]([O-])c1csc(S(=O)(=O)N2CCN(c3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)c1>>Nc1csc(S(=O)(=O)N2CCN(c3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)c1,[Pd],CCO,ClCCl,O=C[O-].[NH4+],,val
US07034015B2,C1COCCN1.CCCC[Sn](/C=C/CBr)(CCCC)CCCC>>CCCC[Sn](/C=C/CN1CCOCC1)(CCCC)CCCC,,CN(C)C=O,,,,val
US20070281942A1,CC(C)CC(Br)C(=O)O.c1ccc2[nH]ncc2c1>>CC(C)CC(C(=O)O)n1cc2ccccc2n1,,O,,,,val
US20030191075A1,Cc1cn([C@H]2C[C@@](O)(COCc3ccccc3)[C@@H](CO)O2)c(=O)n(COCc2ccccc2)c1=O.O=P(O)(O)O>>Cc1cn([C@H]2C[C@@](O)(COCc3ccccc3)[C@@H](C(=O)O)O2)c(=O)n(COCc2ccccc2)c1=O,,CS(C)=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20070282101A1,CC(C)OB(OC(C)C)OC(C)C.c1cnc2sccc2c1>>OB(O)c1cc2cccnc2s1,,C1CCOC1,,Cl,[Li]CCCC,val
US20060167269A1,BrBr.Nc1ccc([N+](=O)[O-])cc1>>Nc1ccc([N+](=O)[O-])cc1Br,,CC(=O)O,,,,val
US20100184778A1,Cc1ncc(N)cc1Nc1nccc(-c2cccnc2)n1.O=C(Cl)c1ccccn1>>Cc1ncc(NC(=O)c2ccccn2)cc1Nc1nccc(-c2cccnc2)n1,,c1ccncc1,,Cl,,val
US04278682,C1=C2c3[nH]c4ccccc4c3CCN2CCC1.C=CC(=O)OCC>>CCOC(=O)CCC1CCCN2CCc3c([nH]c4ccccc34)C12,,ClCCl,,CCO,,val
US20120232056A1,CCOC(=O)CBr.COC(=O)c1ccc(Cl)cc1O>>CCOC(=O)COc1cc(Cl)ccc1C(=O)OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120142717A1,C=C(C(=O)OC)C(OC(C)=O)c1nccs1.CNC(N)=S>>CSc1ncc(Cc2nccs2)c(=O)[nH]1,,CCO,,CCN(CC)CC,,val
US20050288367A1,CCOC(=O)C(Br)CC.Oc1ccc(OCc2ccccc2)cc1>>CCOC(=O)C(CC)Oc1ccc(OCc2ccccc2)cc1,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050282823A1,O=C(NCc1ccccc1)C1CC=CC(O)C1>>OC1C=CCC(CNCc2ccccc2)C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040077605A1,CC(=O)C(C)C(C)C(C)=O>>Cc1oc(C)c(C)c1C,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05684034,CCOC(=O)Cc1c(C)n(Cc2ccccc2)c2ccc(OC)cc12.CO.COc1ccc2c(c1)c(CC(=O)NN)c(C)n2Cc1ccccc1>>CCOCC.COc1ccc2c(c1)c(CC(=O)NN)c(C)n2Cc1ccccc1,,CO,,NN,,val
US04251659,OC(c1ccc2c(c1)CCN2Cc1ccccc1)(C(F)(F)F)C(F)(F)F>>OC(c1ccc2c(c1)CCN2)(C(F)(F)F)C(F)(F)F,[Pd],,,Cl,,val
US05120347,CC(C)(C)NN.O=C(O)C(=O)c1ccccc1>>CC(C)(C)NN=C(O)C(=O)c1ccccc1,,O,,Cl,Cl,val
US04748175,Cc1nc(Cl)c2c(n1)NC(=O)CO2.NCCCN1CCOCC1>>Cc1nc(CCCN2CCOCC2)c2c(n1)NC(=O)C(N)O2,,c1ccccc1,,CCN(CC)CC,,val
US05041448,COc1ccc(CCN2CCC(Cc3nc4c(O)ncnc4n3Cc3ccc(F)cc3)CC2)cc1>>Oc1ccc(CCN2CCC(Cc3nc4c(O)ncnc4n3Cc3ccc(F)cc3)CC2)cc1,,O,,Br,,val
US20070185165A1,C1COCCN1.O=C(Nc1ccc(F)c(Cl)c1)c1nonc1CCCCS(=O)(=O)[O-]>>O=C(Nc1ccc(F)c(Cl)c1)c1nonc1CCCN1CCOCC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20130137865A1,C[Si](C)(C)CCOCn1ncc(-c2nc(-c3cccc(S(N)(=O)=O)c3)no2)c1CCc1ccc(C(F)(F)F)cc1>>NS(=O)(=O)c1cccc(-c2noc(-c3cn[nH]c3CCc3ccc(C(F)(F)F)cc3)n2)c1,,CCO,,Cl,,val
US20070270436A1,CCOC(CC(C(C)=O)c1ccccc1F)OCC>>CC(=O)C(CC=O)c1ccccc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130172317A1,COC(=O)[C@@H](C)Cn1c(=O)[nH]c(=Nc2ccc(OC(C)C)c(Cl)c2)n(C)c1=O.COc1ccc(CCl)cc1>>COC(=O)[C@@H](C)Cn1c(=O)n(C)c(=Nc2ccc(OC(C)C)c(Cl)c2)n(Cc2ccc(OC)cc2)c1=O,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20120157487A1,BrCc1ccccc1.N#Cc1ccc(S)c([N+](=O)[O-])c1>>N#Cc1ccc(SCc2ccccc2)c([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060223890A1,CN1CCN(Cc2cn(S(=O)(=O)c3ccc(F)cc3)c3ccc(Br)cc23)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CN1CCN(Cc2cn(S(=O)(=O)c3ccc(F)cc3)c3ccc(Br)cc23)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O,,CCOCC,,,,val
US20130178478A1,CCOC(=O)c1nnc(Cl)cc1Cl.Nc1cccc(C2CC2)n1>>CCOC(=O)c1nnc(Cl)cc1Nc1cccc(C2CC2)n1,,CC#N,,,,val
US20040229858A1,CC(C)(C)OC(=O)N1CCC[C@H]1CO.COC(=O)c1ccc(O)cc1C(=O)OC>>COC(=O)c1ccc(OC[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1C(=O)OC,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06040433,C[C@@H]1O[C@H](Sc2ccccc2)[C@@H](OC(=O)C(C)(C)C)[C@H](N=[N+]=[N-])[C@@H]1OC(=O)c1ccccc1.O=C(OO)c1cccc(Cl)c1>>C[C@@H]1O[C@H](S(=O)c2ccccc2)[C@@H](OC(=O)C(C)(C)C)[C@H](N=[N+]=[N-])[C@@H]1OC(=O)c1ccccc1,,ClCCl,,,,val
US04758670,CC(C)(C)C1(C(C)(F)n2cncn2)CO1.Oc1ccc(F)cc1>>CC(C)(C)C(O)(COc1ccc(F)cc1)C(C)(F)n1cncn1,,COCCOCCOC,,[K],,val
US20030139435A1,CN(CC(C)(C)C)c1ncnc(Cl)c1[N+](=O)[O-].Cc1ccc(-c2nnc[nH]2)cc1N>>Cc1ccc(-c2nnc[nH]2)cc1Nc1ncnc(N(C)CC(C)(C)C)c1[N+](=O)[O-],,CCCCO,,CCN(C(C)C)C(C)C,,val
US04514416,CON=Cc1ccc(O)c(C(=O)O)c1.N>>N=C(N)c1ccc(O)c(C(=O)O)c1,,CO,,Cl,,val
US04028268,ClCc1cccc2c1ccc1ccccc12.c1ccc2ncccc2c1>>[Cl-].c1ccc2c(c1)ccc1c(C[n+]3cccc4ccccc43)cccc12,,CC(C)O,,,,val
US20070093501A1,CC#N.CCN(CC)CC.CCN=C=NCCCN(C)C.O=C(Nc1ccc(Cl)cc1)OC(C(=O)O)c1ccccc1.On1nnc2ccccc21>>Cc1ncc2n1C(=O)N(N1CCNCC1)C2,,CC#N,,,,val
US20060160877A1,COc1ccccc1B(O)O.O=C(O)c1cc2cccc(Br)c2o1>>COc1ccccc1-c1cccc2cc(C(=O)O)oc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20110212939A1,CC(C)c1noc(N2CCC(CCCO)CC2)n1.O=C1NCc2cc(O)ccc21>>CC(C)c1noc(N2CCC(CCCOc3ccc4c(c3)CNC4=O)CC2)n1,,C1CCOC1,CN(C)C=O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040024034A1,CCCc1cc(OCc2ccccc2)ccc1OCC(=O)OCC>>CCCc1cc(O)ccc1OCC(=O)OCC,[Pd],C1CCOC1,,[H][H],,val
US20130184262A1,O=[N+]([O-])c1ccc(F)cc1.OC1CC2CNC1C2>>O=[N+]([O-])c1ccc(N2CC3CC(O)C2C3)cc1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06596738B1,CC(C)(C)[Si](C)(C)OC[C@@H](CCn1ccc2ccc([N+](=O)[O-])cc21)n1cnc(C(N)=O)c1>>CC(C)(C)[Si](C)(C)OC[C@@H](CCn1ccc2ccc(N)cc21)n1cnc(C(N)=O)c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20150174110A1,CCOC(=O)CCCNC(=O)c1ncc2c(cc(-c3cccc(OC)c3)c(=O)n2Cc2ccccc2)c1O>>COc1cccc(-c2cc3c(O)c(C(=O)NCCCC(=O)O)ncc3n(Cc3ccccc3)c2=O)c1,,C1CCOC1,,CO,[Na+].[OH-],val
US20070088016A1,CC1(C)OB(c2ccc3[nH]c(=O)[nH]c3c2)OC1(C)C.Fc1ccc2c(c1)Sc1cc(F)ccc1C2=CBr>>O=c1[nH]c2ccc(C=C3c4ccc(F)cc4Sc4cc(F)ccc43)cc2[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20110118236A1,C=O.COc1ccc(Cl)cc1NC(=O)Cn1nc(C(F)(F)F)c2c1CCNC2>>COc1ccc(Cl)cc1NC(=O)Cn1nc(C(F)(F)F)c2c1CCN(C)C2,,O=CO,,O=C([O-])[O-].[Na+].[Na+],,val
US20160002175A1,Cc1cccc(-c2cc(Cl)nc(N)n2)c1C.NCCC(=O)N1CCOCC1>>Cc1cccc(-c2cc(NCCC(=O)N3CCOCC3)nc(N)n2)c1C,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20160272617A1,CC(C)(C)OC(=O)N1CC[C@@H](N)C1.Cc1cc(C(=O)O)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nnc(Cl)[nH]3)cc2)cc1>>Cc1cc(C(=O)N[C@@H]2CCN(C(=O)OC(C)(C)C)C2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nnc(Cl)[nH]3)cc2)cc1,,CN(C)C=O,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20070015790A1,ClCOCc1ccccc1.N#Cc1ccc2cc(O)ccc2n1>>N#Cc1ccc2cc(COCc3ccccc3)ccc2n1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120196864A1,CC(C)CBr.O=Cc1ccc(OCc2ccc(C(F)(F)F)cc2C(F)(F)F)c(O)c1>>CC(C)COc1cc(C=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04033994,CC(O)C(=O)O.CC1CCC(C(C)C)C(C(=O)Cl)C1>>CC1CCC(C(C)C)C(C(=O)OC(C)C(=O)O)C1,,O,,,,val
US20130109679A1,Nc1cc(-c2ccccc2)on1.O=C(O)c1ccc2cc3n(c2c1)CCCNC3=O>>O=C(Nc1cc(-c2ccccc2)on1)c1ccc2cc3n(c2c1)CCCNC3=O,,CN1CCCC1=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05272171,CC[Si](CC)(CC)O[C@H]1C(=O)N[C@H]1c1ccccc1.O=C(Cl)c1ccccc1>>CC[Si](CC)(CC)O[C@H]1C(=O)N(C(=O)c2ccccc2)[C@H]1c1ccccc1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20070244131A1,CC(C)(C(=O)O)c1cccc(B(O)O)c1.COc1nc(Cl)cc(NCC2OCCc3ccccc32)n1>>COc1nc(NCC2OCCc3ccccc32)cc(-c2cccc(C(C)(C)C(=O)O)c2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080269218A1,COCOc1cc(OCOC)c(C(C)C)cc1-c1nnc(S(C)(=O)=O)n1C(C)C>>CC(C)c1cc(-c2nnc(S(C)(=O)=O)n2C(C)C)c(O)cc1O,,CO,,Cl,O=C([O-])O.[Na+],val
US20090264425A1,CC(C)(C)OC(=O)N1CCCC(C#N)C1.NO>>CC(C)(C)OC(=O)N1CCCC(C(N)=NO)C1,,CO,,CCN(CC)CC,Cl,val
US20110065708A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.CC(c1cc2cnn(C)c2cc1F)c1cnc2ccc(Cl)nn12>>C=C(OCC)c1ccc2ncc(C(C)c3cc4cnn(C)c4cc3F)n2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20080004269A1,CCCc1cccnc1NC(=O)OC(C)(C)C>>CCCc1cccnc1N,,CCO,,[Na+].[OH-],,val
US20090298807A1,Cc1nc2cc(C(=O)N3CCOC4(CCN(Cc5cc(CCO[Si](C)(C)C(C)(C)C)cs5)CC4)C3)ccc2s1>>Cc1nc2cc(C(=O)N3CCOC4(CCN(Cc5cc(CCO)cs5)CC4)C3)ccc2s1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050277630A1,CC(=O)NC[C@H]1CN(c2ccc3c(c2)OCCCC3=O)C(=O)O1.O=C(Cl)c1ccccc1>>CC(=O)NC[C@H]1CN(c2ccc3c(c2)OCCC(C(=O)c2ccccc2)C3=O)C(=O)O1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20040167127A1,CC(C)(C)OC(=O)NCC(=O)NCC(=O)O.Oc1ccc(-c2nn(C3CCCC3)c3c(F)cccc23)cc1>>CC(C)(C)OC(=O)NCC(=O)NCC(=O)Oc1ccc(-c2nn(C3CCCC3)c3c(F)cccc23)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20120101134A1,Cc1c(C#N)cccc1CO.NO>>Cc1c(CO)cccc1C(=N)NO,,CCO,,Cl,O=C([O-])O.[Na+],val
US20090018054A1,BrC(Br)(Br)Br.OCc1cc2c(cc1I)CCC2>>BrCc1cc2c(cc1I)CCC2,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040259923A1,C=O.CC(=O)Nc1nc(CCc2ccc(CON)cc2)cs1>>C=NOCc1ccc(CCc2csc(NC(C)=O)n2)cc1,,CO,,,,val
US20060154929A1,CCOc1ccc([N+](=O)[O-])c(C)c1>>CCOc1ccc(N)c(CO)c1,[Pd],CCO,,NN,O,val
US20130018064A1,CC(C)(C)Cc1cc(CC(=O)c2cc3cc(Br)ccc3nc2NC(C)(C)C)ncn1.ClCCCBr>>CC(C)(C)Cc1cc(C2=C(c3cc4cc(Br)ccc4nc3NC(C)(C)C)OCCC2)ncn1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06239138B1,COc1ccc(O)c(C=CC(=O)OC(C)(C)C)c1>>COc1ccc(O)c(CCC(=O)OC(C)(C)C)c1,[Pd],CO,,,,val
US20120088748A1,CC(C)(C)[Si](C)(C)OCC(O)C(CN(Cc1ccccc1)C(=O)CCl)c1ccc(Cl)c(Cl)c1>>CC(C)(C)[Si](C)(C)OCC1OCC(=O)N(Cc2ccccc2)CC1c1ccc(Cl)c(Cl)c1,,C1CCOC1,,O,C[O-].[Na+],val
US04545811,COc1nc(N)nc(Cl)n1.O=C=NS(=O)(=O)c1ccccc1OC(F)F>>COc1nc(Cl)nc(NC(=O)NS(=O)(=O)c2ccccc2OC(F)F)n1,,C1COCCO1,,,,val
US20090186912A1,CC(C)(C)c1cccc(Br)c1N.II>>CC(C)(C)c1cc(I)cc(Br)c1N,,O,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20010039286A1,CI.CN(C)C=O.COC(=O)CCc1c(-c2ccc(Cl)cc2)[nH]c2ccc(C(F)(F)F)cc12.O>>COC(=O)CCc1c(-c2ccc(Cl)cc2)n(C)c2ccc(C(=O)OC)cc12,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20010004669A1,CC(C)[Si](Oc1ccc(C(=O)Cl)cc1)(C(C)C)C(C)C.CN1CCN(c2cccc3ccc(N)cc23)CC1>>CC(C)[Si](Oc1ccc(C(=O)Nc2ccc3cccc(N4CCN(C)CC4)c3c2)cc1)(C(C)C)C(C)C,,CC#N,ClCCl,CCN(CC)CC,,val
US05681858,BrC(Br)(Br)Br.O=C[C@H]1CC[C@@H](Oc2ccc(F)cc2)C1>>Fc1ccc(O[C@@H]2CC[C@H](C=C(Br)Br)C2)cc1,[Zn],ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060089365A1,CN(C)c1ccc(C#N)cn1.NO>>CN(C)c1ccc(C(=N)NO)cn1,,CCO,,,,val
US20150018422A1,COc1ccc(COc2ccc(-c3cc(OC)ncc3F)c(C(=O)C(C)(C)C)c2)cc1>>COc1ccc(COc2ccc(-c3cc(OC)ncc3F)c(C(O)C(C)(C)C)c2)cc1,,CO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20070270467A1,CC(C)(C)OC(=O)N1CCC(O)(c2ccc(Cl)c(C(F)(F)F)c2)CC1>>OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160272617A1,CC(C)(C)OC(=O)N1CCC(N)CC1.CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](C(=O)N[C@@H](Cc2ccc(-c3ccc(C(=O)O)c(F)c3)cc2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)CC1>>CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](C(=O)N[C@@H](Cc2ccc(-c3ccc(C(=O)NC4CCN(C(=O)OC(C)(C)C)CC4)c(F)c3)cc2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150210677A1,NC1=C(O)C(=O)C(c2ccc(Cl)c(Cl)c2)O1.O=S(=O)(Cl)Cc1ccccc1>>NC1=C(OS(=O)(=O)Cc2ccccc2)C(=O)C(c2ccc(Cl)c(Cl)c2)O1,,C1CCOC1,,CCN(CC)CC,[Cl-].[NH4+],val
US20090186879A1,CC(=O)OC(C)=O.CCC(O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ncc(Cl)cc1Cl>>CCC(OC(C)=O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ncc(Cl)cc1Cl,,c1ccncc1,,,,val
US04343811,CI.Cc1[nH]c2ccc(OCc3ccccc3)cc2c1-c1cccc(Cl)c1>>Cc1c(-c2cccc(Cl)c2)c2cc(OCc3ccccc3)ccc2n1C,,CN(C)C=O,,[H-].[Na+],,val
US20110288089A1,C=C(c1cc(Cl)cc(Cl)c1)C(F)(F)F.Cc1nc2c(C(Cl)=NO)ccc(Br)c2o1>>Cc1nc2c(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)ccc(Br)c2o1,,CC(C)O,,O=C([O-])O.[Na+],,val
US20140296069A1,CSSC.Cc1cc(Br)c(NC(=O)C(F)(F)F)c(Br)c1>>CSc1cc(C)cc(Br)c1NC(=O)C(F)(F)F,,CCCCCC,CCOCC,Cl,[Li]CCCC,val
US20090131458A1,COc1nc2c(N)nc(OCCOC(C)C)nc2[nH]1.CS(=O)(=O)OCC1CCOCC1>>COc1nc2c(N)nc(OCCOC(C)C)nc2n1CC1CCOCC1,,CCOC(C)=O,CN(C)C=O,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US05516931,C#CCO.Fc1c(F)c(F)c(-c2c(F)c(F)c(F)c(F)c2F)c(F)c1F>>C#CCOc1c(F)c(F)c(-c2c(F)c(F)c(F)c(F)c2F)c(F)c1F,,Cc1ccccc1,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US06265575B1,C=C(c1ccc(OC)cc1)c1c(-c2ccc(OC)cc2)sc2ccccc12>>C=C(c1ccc(O)cc1)c1c(-c2ccc(O)cc2)sc2ccccc12,,CCOC(C)=O,,,,val
US20150329523A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Oc2ccccc2)cc1.Nc1ccc(Oc2ccnc(Cl)n2)c(Cl)c1Cl>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c(Cl)c2Cl)cc1,,CC(=O)OC(C)C,,CCN(CC)CC,,val
US20140005146A1,CC(C)N.NC(=O)c1cnn2cc(Br)cc2c1Cl>>CC(C)Nc1c(C(N)=O)cnn2cc(Br)cc12,,CN(C)C=O,O,,,val
US20130072492A1,Cl.N#Cc1cccnn1>>Cl.NCc1cccnn1,[Pd],CO,,[H][H],,val
US20100141127A1,CC(C)c1cccc(C(C)C)c1N.O=[N+]([O-])c1ccccc1F>>CC(C)c1cccc(C(C)C)c1Nc1ccccc1[N+](=O)[O-],,O,,[F-].[K+],,val
US20110212937A1,Fc1ccc([Mg]Br)cc1.O=C1CCCC1>>Fc1ccc(C2=CCCC2)cc1,,C1CCOC1,,Cl,,val
US20080108638A1,CCCCOC(=O)N(CCCSc1nc2ccccc2n1CC(=O)OC(C)(C)C)CCc1ccccc1>>CCCCOC(=O)N(CCCSc1nc2ccccc2n1CC(=O)O)CCc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100075952A1,Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCCC1)CCC2.O=C1Cc2cc(S(=O)(=O)Cc3ccc(F)cc3)ccc2N1>>Cc1c(C=C2C(=O)Nc3ccc(S(=O)(=O)Cc4ccc(F)cc4)cc32)[nH]c2c1C(=O)N(CCN1CCCC1)CCC2,,CCO,,C1CCNCC1,,val
US05998433,COc1ccccc1C(=O)c1ccc(C(=O)N2CCc3cc(CN(C)C)oc3C2)cc1.Cl>>COc1ccccc1C(=O)c1ccc(C(=O)N2CCc3cc(CN(C)C)oc3C2)cc1.Cl,,CCOC(C)=O,CO,,,val
US20160039834A1,Cc1onc(CO)c1-c1nc(-c2cccc(OCC(CN(C)C(=O)OC(C)(C)C)O[Si](C)(C)C(C)(C)C)c2)nc(NC2CCOCC2)c1C>>CNCC(O)COc1cccc(-c2nc(NC3CCOCC3)c(C)c(-c3c(CO)noc3C)n2)c1.O=CO,,C1COCCO1,ClCCl,Cl,,val
US20150133428A1,CCOC(=O)c1c(I)nn2c1C(=O)NC1(CC1)C2>>CCOC(=O)c1c(I)nn2c1CNC1(CC1)C2,,C1CCOC1,,CSC,,val
US20150099770A1,COc1cc(OCCCO)ccc1Cc1c(C)nc(N)nc1O.Cc1cc(C)c(S(=O)(=O)Cl)c(C)c1>>COc1cc(OCCCO)ccc1Cc1c(C)nc(N)nc1OS(=O)(=O)c1c(C)cc(C)cc1C,,C1CCOC1,O,CCN(C(C)C)C(C)C,Cl,val
US06528538B1,CCOC(=O)C1(c2ccc(Cl)cc2)OCC(c2ccc(F)cc2)(c2ccc(F)cc2)CO1>>O=C(O)C1(c2ccc(Cl)cc2)OCC(c2ccc(F)cc2)(c2ccc(F)cc2)CO1,,CO,,O,[Na+].[OH-],val
US20160257701A1,CS(=O)(=O)Cl.OCc1cccc(CN2CCc3sccc3C2)c1>>CS(=O)(=O)OCc1cccc(CN2CCc3sccc3C2)c1,,C1CCOC1,,CCN(CC)CC,,val
US20110002855A1,Cc1ncc2c3c(sc2n1)CNCC3.O=C(CCl)N1CCN(C2CCC2)CC1>>Cc1ncc2c3c(sc2n1)CN(CC(=O)N1CCN(C2CCC2)CC1)CC3,,CC#N,O,[I-].[K+],O=C([O-])O.[Na+],val
US20150011548A1,CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)cnc32)c1>>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)cnc32)c1,,ClCCl,,c1ccncc1,,val
US20100130495A1,Cc1nccn1-c1ccc(Nc2nc(O)c3c(n2)CCN(C(=O)OC(C)(C)C)C3)cc1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1nccn1-c1ccc(Nc2nc3c(c(OS(=O)(=O)C(F)(F)F)n2)CN(C(=O)OC(C)(C)C)CC3)cc1,CN(C)c1ccncc1,ClCCl,,C1CCC2=NCCCN2CC1,,val
US20130184263A1,CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2C4=C(C(C)C)C(=O)C[C@]4(CCN)CC[C@]23C)C1(C)C.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2C4=C(C(C)C)C(=O)C[C@]4(CCNC(=O)OC(C)(C)C)CC[C@]23C)C1(C)C,,ClCCl,,,,val
US20120101083A1,CC(C)Oc1ccc(-c2nc(-c3cccc4c3CCN(CC(=O)OC(C)(C)C)C4)no2)cc1C#N.O=C(O)C(F)(F)F>>CC(C)Oc1ccc(-c2nc(-c3cccc4c3CCN(CC(=O)O)C4)no2)cc1C#N.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20090209522A1,COc1nc(NCCN(C(=O)OC(C)(C)C)C(C)C)nc(OC)c1NC(=O)c1csc(Oc2cc(C(C)(C)C)ccc2Cl)n1>>COc1nc(NCCNC(C)C)nc(OC)c1NC(=O)c1csc(Oc2cc(C(C)(C)C)ccc2Cl)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05840917,CCOC(=O)c1ccc(C(F)F)o1>>O=C(O)c1ccc(C(F)F)o1,,CCO,,[Na+].[OH-],,val
US20160002248A1,N#CCCCCc1cc2cc(Cc3ccccc3)[nH]c2nn1.NNC(N)=S>>Nc1nnc(CCCCc2cc3cc(Cc4ccccc4)[nH]c3nn2)s1,,O=C(O)C(F)(F)F,,,,val
US06177452B1,COC(=O)CCc1oc(Cl)nc1-c1ccc(Cl)cc1>>O=C(O)CCc1oc(Cl)nc1-c1ccc(Cl)cc1,,CCO,,Cl,[Na+].[OH-],val
US20030036557A1,CS(=O)(=O)c1ccc(NC(=N)c2ccc(Cl)cc2)cc1.O=C(CBr)Cc1ccccc1Oc1ccc(Cl)cc1>>CS(=O)(=O)c1ccc(N2CC(O)(COc3ccc(Cl)cc3)N=C2c2ccc(Cl)cc2)cc1,,CC(C)=O,,O=C([O-])O.[Na+],,val
US05514680,CCOC(=O)C(=O)OCC.Nc1cc(F)c(F)c(Cl)c1N>>O=c1[nH]c2cc(F)c(F)c(Cl)c2[nH]c1=O,Cl,,,,,val
US20160120850A1,CCOC(=O)c1nc(CO)cs1.C[Si](C)(C)CCOCCl>>CCOC(=O)c1nc(COCOCC[Si](C)(C)C)cs1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080009479A1,CC(C)(C)OC(=O)N1CCc2ccc(O)cc2CC1.Ic1ccccc1>>CC(C)(C)OC(=O)N1CCc2ccc(Oc3ccccc3)cc2CC1,[Cu]Br,c1ccncc1,,[H-].[Na+],,val
US07750129B2,CCCS(=O)(=O)c1csc(C(=O)O)c1N.O=C1CCC(=O)N1O.[Na+].[OH-]>>CCCS(=O)(=O)c1csc(C(=O)O)c1N.O=C([O-])O.[Na+],,CCO,,O,,val
US20120184587A1,N#Cc1cc(C(=O)N2CS(=O)(=O)c3ccccc32)ccc1O.O=C1CCC(=O)N1I>>N#Cc1cc(C(=O)N2CS(=O)(=O)c3ccccc32)cc(I)c1O,,CO,ClCCl,O=S(=O)(O)C(F)(F)F,,val
US06432955B1,CC(C)(C)OC(=O)[C@@H](N)Cc1ccccc1.COc1cc(C)c(S(=O)(=O)Cl)c(C)c1C>>COc1cc(C)c(S(=O)(=O)N[C@@H](C)Cc2ccccc2)c(C)c1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20080113966A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC=O)cnc21.C[Mg]Br>>CC(O)Cc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)OC(C)(C)C,,C1CCOC1,,,,val
US05112998,CC(C)(CO)CO.CC(C=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4=CC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C>>CC(C1OCC(C)(C)CO1)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C,Cc1ccc(S(=O)(=O)O)cc1,c1ccccc1,,O,,val
US20090069328A1,CC(C)Oc1ccc(C#Cc2ccccc2)cc1C(=O)O.COC(=O)C(C)(N)Cc1c[nH]c2ccccc12>>COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)c1cc(C#Cc2ccccc2)ccc1OC(C)C,,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20110172237A1,Cc1ccc(N)cn1.O=C(Cl)CCl>>Cc1ccc(NC(=O)CCl)cn1,,C1CCOC1,,CCN(CC)CC,O,val
US20080039444A1,CC(C)(C)OC(=O)N1CCC[C@@H]1CO.O=c1[nH]nc(Cl)c2ccccc12>>CC(C)(C)OC(=O)N1CCC[C@@H]1Cn1nc(Cl)c2ccccc2c1=O,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US07435744B2,CC(C)(C)OC(=O)N1CCc2cc(N)ccc21.O=C(Cl)C(=O)N1CCC(Cc2ccccc2)CC1>>O=C(Nc1ccc2c(c1)CCN2)C(=O)N1CCC(Cc2ccccc2)CC1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US04716167,CCOC(=O)c1cc2c(=O)c3cc(C(C)CO)ccc3oc2nc1N>>CC(CO)c1ccc2oc3nc(N)c(C(=O)O)cc3c(=O)c2c1,,O,,CCO,[Na+].[OH-],val
US20100197683A1,CC#N.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n([C@@H]2CC[C@@H](OC(C)CO)CC2)c2ncnn12>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n([C@@H]2CC[C@@H](OC(C)C3CO3)CC2)c2ncnn12,,CC#N,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US04518597,CC(=O)Oc1ccc2c(c1)COC(=O)N2.O=S(=O)(Cl)Cl>>CC(=O)Oc1cc(Cl)c2c(c1)COC(=O)N2,,CC(=O)O,,CCOCC,,val
US04020171,C1CCOC1.CSCS(C)=O.[Li]CCCC>>CSC1(S(C)=O)CCCC1,,C1CCOC1,,CCCCCC,,val
US05326497,CCCBr.C[Si](C)(C)Oc1ccc(-c2ccc(CCCCCO)cc2)nc1>>CCCOCCCCCc1ccc(-c2ccc(O)cn2)cc1,,C1CCOC1,,[H-].[Na+],,val
US20130281449A1,Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(CF)COC(CF)(CF)C(NC(=O)OC(C)(C)C)=N2)c1>>Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(CF)COC(CF)(CF)C(N)=N2)c1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20080103133A1,CC(C)(C)OC(=O)N[C@H]1CNc2cc(F)c(F)cc2NC1=O.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N[C@H]1CNc2cc(F)c(F)cc2N(CC(F)(F)F)C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05514717,FC(F)(Br)C(F)(Cl)CCBr.O>>OCCC(F)(Cl)C(F)(F)Br,,O,,CN1CCCC1=O,,val
US05686424,CC[C@H](C)[C@H](N)C(=O)NCc1ccccc1.O=C(CBr)c1ccc2ccccc2c1.O=C(O)[C@@H]1CCCN1>>CC[C@H](C)[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)c1ccc2ccccc2c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110105503A1,O=C(CC1(O)CCN(Cc2ccc3c(c2)OCO3)CC1)c1ccccc1.O=S(Cl)Cl>>Cl.O=C(CC1(Cl)CCN(Cc2ccc3c(c2)OCO3)CC1)c1ccccc1,,ClCCl,,,,val
US20090069420A1,CCOC(=O)c1ccc(N)cc1.O=C(Cl)/C=C/c1ccc2ccccc2c1>>CCOC(=O)c1ccc(NC(=O)C=Cc2ccc3ccccc3c2)cc1,,ClCCl,,c1ccncc1,,val
US20120213758A1,COC.COc1cccc(F)c1Br>>COc1ccc(C=O)c(F)c1Br,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20130165494A1,CC(=O)OCC(=O)NCCc1cc(-c2ccc(S(C)(=O)=O)cc2)n(-c2ccccc2)c1C>>Cc1c(CCNC(=O)CO)cc(-c2ccc(S(C)(=O)=O)cc2)n1-c1ccccc1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US04251443,CN(C)C(=O)Cl.CN1C(=O)CN=C(c2ccccc2F)c2cc(N)ccc21>>CN(C)C(=O)Nc1ccc2c(c1)C(c1ccccc1F)=NCC(=O)N2C,,ClCCl,,O,O=C([O-])[O-].[K+].[K+],val
US20110144334A1,CCOC(=O)C(F)(F)Br.O=[N+]([O-])c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1O>>O=[N+]([O-])c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1OC(F)F,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20100210680A1,C=C(C)c1ccc2c(c1Cl)CO[C@@]1(C)CN(Cc3ccccc3)C[C@@H]21.CC(Cl)OC(=O)Cl>>C=C(C)c1ccc2c(c1Cl)CO[C@@]1(C)CNC[C@@H]21.Cl,,Cc1ccccc1,,CO,,val
US20090281107A1,CSc1ccc(-n2nc3c(=O)n(Cc4ccc(C(F)(F)F)cc4)nc-3cc2-c2ccc(O)cc2Cl)cc1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CSc1ccc(-n2nc3c(=O)n(Cc4ccc(C(F)(F)F)cc4)nc-3cc2-c2ccc(OCC(F)(F)F)cc2Cl)cc1,,CCO,,O=C([O-])O.[Na+],,val
US20030207879A1,CCCn1c(=O)c2c(n(CCC)c1=O)=N/C(=C1/C=C(NC(=O)Cc3ccc(OCc4ccccc4)cc3)NN1C)N=2>>C=CCn1c(=O)c2[nH]c(-c3cc(N)nn3C)nc2n(CC=C)c1=O,,[Na+],[OH-],Cl,,val
US20100298337A1,CC(C)(C)C(=O)Cl.C[Si](C)(C)C#Cc1cncc(Br)c1>>CC(C)(C)C(=O)C#Cc1cncc(Br)c1,Cl[Cu],CN(C)C=O,,,,val
US20070185165A1,NCc1nonc1-c1noc(=O)n1-c1ccc(F)c(Cl)c1.O=S(=O)(Cl)CCCCl>>O=c1onc(-c2nonc2CNS(=O)(=O)CCCCl)n1-c1ccc(F)c(Cl)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090203736A1,CC(C)(C)OC(=O)N1CCCC(C(=O)N2CCCCC2c2ccccc2)C1>>O=C(C1CCCNC1)N1CCCCC1c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050203302A1,CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CCC(=O)CC(=O)O[C@H](c1ccccc1)C(O)(c1ccccc1)c1ccccc1>>CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)CC(=O)O[C@H](c1ccccc1)C(O)(c1ccccc1)c1ccccc1,,C1CCOC1,CO,[BH4-].[Na+],,val
US20080161366A1,O=[N+]([O-])c1ccccc1Nc1ccccc1F>>Nc1ccccc1Nc1ccccc1F,[Pd],CCOC(C)=O,,,,val
US05811428,Nc1cc(Cl)cc(Cl)c1.O=Cc1ccccc1>>Clc1cc(Cl)cc(NCc2ccccc2)c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US05284954,C[Si](C)(C)N=[N+]=[N-].N#Cc1ccccc1N>>Nc1ccccc1-c1nnn[nH]1,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US20050215556A1,C=C[Sn](CCCC)(CCCC)CCCC.O=[N+]([O-])c1cc(Br)ccc1OCc1ccccc1>>C=Cc1ccc(OCc2ccccc2)c([N+](=O)[O-])c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20130225552A1,CC(C)(C)OC(=O)N[C@@H]1C[C@@H](n2ccc3cccnc32)C1>>N[C@H]1C[C@H](n2ccc3cccnc32)C1,,CCOC(C)=O,ClCCl,CO,O=C(O)C(F)(F)F,val
US20070093505A1,CC(C)(C)O.O=C1OC(=O)c2nc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)nc21>>CC(C)(C)OC(=O)c1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)nc1C(=O)O,CN(C)c1ccncc1,CC#N,,,,val
US20090111860A1,Cc1cc(C(C)NC(=O)OC(C)(C)C)ns1.O=S(=O)(Cl)c1ccc(Cl)cc1>>Cc1cc(C(C)NS(=O)(=O)c2ccc(Cl)cc2)ns1,,C1COCCO1,ClCCl,Cl,,val
US20070021614A1,CO.NCCc1c(CCCc2ccc(C(=O)O)cc2)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1>>COC(=O)c1ccc(CCCc2c(CCN)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1,,CC#N,,C[Si](C)(C)C=[N+]=[N-],,val
US06897210B2,COCCO.O=[N+]([O-])c1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1Cl>>COCCON1CN=C(Nc2ccc(Cl)cc2F)c2cc([N+](=O)[O-])ccc21,,CC(=O)O,O,Cl,[Na],val
US20090298883A1,N#CCN1CCC(CNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1>>NCCN1CCC(CNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1,[Ni],CO,,,,val
US20110190269A1,COc1cc(Br)ccc1-n1cnc(C)c1.Nc1nc2c(-c3ccc(F)cc3)cccn2n1>>COc1cc(Nc2nc3c(-c4ccc(F)cc4)cccn3n2)ccc1-n1cnc(C)c1,,ClCCl,,,,val
US20150225381A1,CC(C)(C)OC(=O)NC1(CO)CC1.CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1c1ccc(O)nc1>>CC(C)(C)OC(=O)NC1(COc2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cn2)CC1,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070049593A1,COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc(Cl)cc3N)[nH]c2c1.O=C(Cl)CCl>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc(Cl)cc3NC(=O)CCl)[nH]c2c1,,C1CCOC1,,CC(=O)O,CC(=O)[O-].[Na+],val
US07109243B2,Cc1cccc(C(=O)Cl)c1.N[C@@H](CCCC1CCCCC1)C(=O)O>>Cc1cccc(C(=O)N[C@@H](CCCC2CCCCC2)C(=O)O)c1,,O,,[Na+].[OH-],,val
US20080293704A1,CNC.O=C(NCc1cn(-c2ccc(-n3ccccc3=O)cc2-c2ccnc(F)c2)nn1)c1ccc(Cl)s1>>CN(C)c1cc(-c2cc(-n3ccccc3=O)ccc2-n2cc(CNC(=O)c3ccc(Cl)s3)nn2)ccn1,,CS(C)=O,,,,val
US20130225620A1,CC(C)(C)OC(=O)n1ccc2c(Cl)c(CN3C(=O)c4ccccc4C3=O)ccc21>>CC(C)(C)OC(=O)n1ccc2c(Cl)c(CN)ccc21,,CCO,O,NN,,val
US20040054177A1,Nc1nc(Br)ccc1[N+](=O)[O-].OB(O)c1ccccc1F>>Nc1ccc(-c2ccccc2F)nc1N,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20140336106A1,COc1ccc(C[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1.O=C(O)[C@H]1CCCO1>>COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)[C@H]2CCCO2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090012129A1,COC(=O)/C(=C/c1ccc(-c2cccc(N(C)C(=O)NCCc3ccccc3)c2)cc1)OC>>CO/C(=C\c1ccc(-c2cccc(N(C)C(=O)NCCc3ccccc3)c2)cc1)C(=O)O,,C1CCOC1,,CC(=O)O,[Na+].[OH-],val
US20080039455A1,COc1cc(OC)cc(-c2c[nH]nc2N)c1.Cn1ccc(=O)n(C)c1=O>>COc1cc(OC)cc(-c2cnn3ccc(=O)[nH]c23)c1,,CCO,CCO,C,C[O-].[Na+],val
US20060089371A1,COC(=O)[C@H](Cc1ccccc1)Nc1ncnc(-c2ccc(OCc3ccccc3)cc2)c1C=O>>COC(=O)[C@H](Cc1ccccc1)Nc1ncnc(-c2ccc(OCc3ccccc3)cc2)c1CO,,CO,,[BH4-].[Na+],,val
US20110269739A1,CI.COC(C)(OC)N(C)C.NC(N)=S>>CSC(=N)N=C(C)N(C)C,,ClCCl,,C1CCOC1,,val
US04507498,CCCc1c(O)ccc(C(C)=O)c1O.CCCc1c(OCC(=O)OCC)ccc(C(C)=O)c1OCCCBr>>CCCc1c(OCCCOc2c(C(C)=O)ccc(OCC(=O)OCC)c2CCC)ccc(C(C)=O)c1O,,CC(C)=O,CN(C)C=O,[I-].[K+],,val
US05344845,COc1cc(C=CC(=O)N[C@@H]2CC[C@@H](C)CC2)ccc1OCCCl>>C=COc1ccc(C=CC(=O)N[C@@H]2CC[C@@H](C)CC2)cc1OC,,C1CCOC1,,Cl,[H-].[Na+],val
US09394305B2,CCOC(=O)c1cnc2ccc(N3CCCC3c3cc(F)ccc3O[C@@H]3CCOC3)cn12>>O=C(O)c1cnc2ccc(N3CCCC3c3cc(F)ccc3O[C@@H]3CCOC3)cn12,,CCO,,[Li+].[OH-],,val
US04291060,CCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCC.O=C(Cl)COc1ccc(C(Cl)Cl)cc1>>CCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCC)C(=O)COc1ccc(C(Cl)Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20070265225A1,CCOC(=O)CN1C(=O)C(C)(C)[C@@H](O)C[C@H]1c1cc(F)cc(F)c1>>CC1(C)C(=O)N(CC(=O)O)[C@H](c2cc(F)cc(F)c2)C[C@@H]1O,,C1CCOC1,O,Cl,,val
US20010034343A1,CCOC(=O)N1CCCN(c2nc3ccccc3[nH]2)CC1.CCOC(=O)c1ccc(CCl)o1>>CCOC(=O)c1ccc(Cn2c(N3CCCN(C(=O)OCC)CC3)nc3ccccc32)o1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20040092546A1,CNC(=O)c1ccc[nH]1.O=C(Cl)c1cccnc1Cl>>CNC(=O)c1ccc(C(=O)c2cccnc2Cl)[nH]1,,CCOC(C)=O,c1ccccc1,Cl[Sn](Cl)(Cl)Cl,,val
US20040053908A1,N#Cc1cc2c(Oc3ccc(N)c(F)c3)ccnc2cc1OCc1ccccc1.O=C(Cl)Oc1ccccc1>>N#Cc1cc2c(Oc3ccc(NC(=O)Oc4ccccc4)c(F)c3)ccnc2cc1OCc1ccccc1,,CN(C)C=O,c1ccncc1,Cc1ccccc1,O,val
US20110137068A1,C1CCOC1.CNc1cccc(C(=O)O)c1F.O=C(Cl)c1ccccc1>>COC(=O)c1cccc(N(C)C(=O)c2ccccc2)c1F,,C1CCOC1,,CCOC(C)=O,c1ccncc1,val
US20020007071A1,CC(C)(C)OC(=O)N1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(OCCCBr)cccc32)CC1.CC1CCNCC1>>CC1CCN(CCCOc2cccc3c2nc(COc2ccc(Cl)cc2)n3CCCC2CCN(C(=O)OC(C)(C)C)CC2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06969711B2,CCCCCCCNC(=O)CBr.OCCN1CCNCC1>>CCCCCCCNC(=O)CN1CCN(CCO)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20140315881A1,Cc1ccc(C(NC(=O)Cc2ccc3oc(C(c4ccncc4)N4CCN(C(=O)OC(C)(C)C)CC4)cc3c2)c2ccccc2)c(C)c1>>Cc1ccc(C(NC(=O)Cc2ccc3oc(C(c4ccncc4)N4CCNCC4)cc3c2)c2ccccc2)c(C)c1,,ClCCl,O=C(O)C(F)(F)F,[Na+].[OH-],,val
US20140296252A1,CCOC(=N)CC(C)C.CCOC(=O)Cl>>CCOC(=O)N=C(CC(C)C)OCC,,CCOC(C)=O,ClCCl,Cl,c1ccncc1,val
US20160145247A1,CC(C)(C)OC(=O)Cc1ccccc1OCc1cc(NCC2CCCO2)c(F)c(-c2cccc(CNC(=O)OC(C)(C)C)c2)c1>>NCc1cccc(-c2cc(COc3ccccc3CC(=O)O)cc(NCC3CCCO3)c2F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160166560A1,CN(C(=O)n1cnc(-c2cccc(NC(N)=O)c2)c1)C1CCN(Cc2ccccc2)CC1.CS(=O)(=O)O>>CN(C(=O)n1cnc(-c2cccc(NC(N)=O)c2)c1)C1CCN(Cc2ccccc2)CC1.CS(=O)(=O)O,,CCOC(C)=O,,,,val
US20090275578A1,N#CCCc1ccccc1F>>NCCCc1ccccc1F,,C1CCOC1,,,,val
US20070004675A1,Cn1ccnc1-c1cc2nccc(Oc3ccc(N)cc3F)c2s1.O=C(O)CC(=O)Nc1ccccc1>>Cn1ccnc1-c1cc2nccc(Oc3ccc(NC(=O)CC(=O)Nc4ccccc4)cc3F)c2s1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20080018238A1,CN1c2ccc(Br)cc2Sc2cc(Br)ccc21.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.OB(O)c1ccc2ccccc2c1>>CN1c2ccc(-c3ccc4ccccc4c3)cc2Sc2cc(-c3ccc4ccccc4c3)ccc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20080125413A1,C=CCN(C(=O)OC(C)(C)C)C1CCN(C(=O)OCc2ccccc2)CC1.O=[O+][O-]>>CC(C)(C)OC(=O)N(CC=O)C1CCN(C(=O)OCc2ccccc2)CC1,,CO,ClCCl,CSC,,val
US20070027155A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.Fc1ccc(-c2cc(N3CCN(c4ncccc4C(F)(F)F)CC3)nc(Cl)n2)cc1Cl>>CC(C)(C)OC(=O)N1CC=C(c2nc(-c3ccc(F)c(Cl)c3)cc(N3CCN(c4ncccc4C(F)(F)F)CC3)n2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20100087657A1,CC(Oc1c(Cl)cccc1Cl)C1=NCCN1.Cl>>CC(Oc1c(Cl)cccc1Cl)C1=NCCN1.Cl,,CCOCC,,CC(C)O,,val
US04569801,Br.CCCCCCCN(CC)CCCCc1ccc(NS(C)(=O)=O)cc1>>Br.CCCCCCCN(CC)CCCCc1ccc(NS(C)(=O)=O)cc1,,CCOCC,,,,val
US20150344494A1,Nc1cccc(-c2csc3c(=O)cc(N4CCOCC4)oc23)c1.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>O=C(Nc1cccc(-c2csc3c(=O)cc(N4CCOCC4)oc23)c1)Nc1ccc(Cl)c(C(F)(F)F)c1,,ClCCCl,,CO,,val
US05527819,O=C(NCc1cccc([N+](=O)[O-])c1)c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1>>Nc1cccc(CNC(=O)c2[nH]c3ccc(Cl)cc3c2S(=O)(=O)c2ccccc2)c1,O=[Pt],C1CCOC1,CO,[H][H],,val
US20120134959A1,Clc1cc(N2C3CCC2COC3)nc(Cl)n1.I>>Clc1cc(N2C3CCC2COC3)nc(I)n1,,ClC(Cl)Cl,O,[I-].[Na+],,val
US20160222014A1,CC(C)(C)OC(=O)N1CCNC(=O)C1.Nc1ccc(I)cn1>>CC(C)(C)OC(=O)N1CCN(c2ccc(N)nc2)C(=O)C1,[Cu]I,C1COCCO1,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20130090327A1,CC(=O)OCC(=O)N1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc(NC(=O)Oc6ccccc6)cc5F)c4s3)nc2)CC1.NC1COC1>>O=C(Nc1ccc(Oc2ccnc3cc(-c4ccc(CN5CCN(C(=O)CO)CC5)cn4)sc23)c(F)c1)NC1COC1,,C1CCOC1,CO,O=C([O-])[O-].[K+].[K+],,val
US20020156087A1,NCCNc1ccc([N+](=O)[O-])cn1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>O=[N+]([O-])c1ccc(NCCNS(=O)(=O)c2ccccc2[N+](=O)[O-])nc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100331293A1,Cc1c(N2CCCCC2)nc2cc(F)cc(F)c2c1Cl.Nc1cc(N2CCOCC2)cnc1N1CCOCC1>>Cc1c(N2CCCCC2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1,,Cc1ccccc1,,,,val
US08916549B2,CC1CN(C(=O)OC(C)(C)C)Cc2scc(C3CC3)c2O1>>CC1CNCc2scc(C3CC3)c2O1,,CCOC(C)=O,Cl,,,val
US20130338196A1,COC(=O)c1nnc(C(O[Si](C)(C)C(C)(C)C)C2CCc3cc(Oc4ccccc4)ccc3C2)o1>>COC(=O)c1nnc(C(O)C2CCc3cc(Oc4ccccc4)ccc3C2)o1,,C1CCOC1,CCOC(C)=O,,,val
US20050026916A1,CSC1=N[C@@H]2CCCC[C@@H]2N1C(=O)OC(C)(C)C.NCc1ccccc1>>CC(C)(C)OC(=O)N1C(NCc2ccccc2)=N[C@@H]2CCCC[C@@H]21,,ClCCl,,,,val
US04880808,Cc1ccc(F)cc1NC(=O)CN1CCNC(C(N)=O)C1.Fc1ccc(C(CCCCCl)c2ccc(F)cc2)cc1>>Cc1ccc(F)cc1NC(=O)CN1CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)C(C(N)=O)C1.Cl,,CCN(CC)CC,CN(C)C=O,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20050054696A1,NNC(=O)c1cc2cc(Cl)ccc2[nH]1.O=C(O)CNc1ccccc1>>O=C(CNc1ccccc1)NNC(=O)c1cc2cc(Cl)ccc2[nH]1,,CN(C)C=O,O,ClCCCl,On1nnc2ccccc21,val
US20090182002A1,CNCC1COCCO1.O=C(Cl)OCc1ccccc1>>CN(CC1COCCO1)C(=O)OCc1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US20120323012A1,CC(C)(C)OC(=O)N1CCC(O)(c2ccc(OCc3ccccc3)cc2OCc2ccccc2)CC1>>CC(C)(C)OC(=O)N1CCC(c2ccc(O)cc2O)CC1,[Pd],CCOC(C)=O,CO,,,val
US20130059853A1,COc1ccc(-c2cccc3c2CCC3=O)c(OCC2(CN=[N+]=[N-])CC2)c1OC>>COc1ccc(-c2cccc3c2CCC3=O)c(OCC2(CN)CC2)c1OC,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070225300A1,CC1(C)CN(CC2Cc3ccc(Cl)nc3C2)c2nc(-c3ccncc3)cc(=O)n2C1.OB(O)c1ccncc1>>CC1(C)CN(CC2Cc3ccc(-c4ccncc4)nc3C2)c2nc(-c3ccncc3)cc(=O)n2C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],val
US20130165412A1,NCC1CCOCC1.O=C(O)c1nn(-c2ccc(F)cc2F)c2c1C[C@@H]1C[C@H]21>>O=C(NCC1CCOCC1)c1nn(-c2ccc(F)cc2F)c2c1C[C@@H]1C[C@H]21,,C1CCOC1,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080132459A1,CC(C)(C)OC(=O)c1ccc(F)cc1.NCCN1CCCCC1>>CC(C)(C)OC(=O)c1ccc(NCCN2CCCCC2)cc1,,CCOC(C)=O,,,,val
US04018933,O=C(O)Cc1ccc(N2C=NCC2)cc1.O=S(Cl)Cl>>Cl.O=C(Cl)Cc1ccc(N2C=NCC2)cc1,,c1ccccc1,,,,val
US20120108583A1,CNc1c(N)cc(C(=O)OC)c2c1CC(C)(C)O2.S=C=Nc1c(Cl)cncc1Cl>>COC(=O)c1cc2nc(Nc3c(Cl)cncc3Cl)n(C)c2c2c1OC(C)(C)C2,,CC#N,,,,val
US20070197531A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C[C@@H]1CC[C@@H](N)CC1>>CCOC(=O)C[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20110196002A1,COC(=O)C(NC(=O)c1nc(-c2ccc(N)cc2)no1)C(C)C.O=C=Nc1ccc(F)cc1F>>COC(=O)C(NC(=O)c1nc(-c2ccc(NC(=O)Nc3ccc(F)cc3F)cc2)no1)C(C)C,,CCOC(C)=O,,C1CCOC1,,val
US20050267093A1,CCN(CC)C(C)COc1ccc(N)cc1.O=C(O)C#Cc1ccc(C(F)(F)F)cc1Cl>>CCN(CC)C(C)COc1ccc(NC(=O)C#Cc2ccc(C(F)(F)F)cc2Cl)cc1,,CO,ClCCl,,,val
US20120088755A1,Cc1cc(NC(=O)OC(C)(C)C)cc2oc(=O)n(C)c12>>Cc1cc(N)cc2oc(=O)n(C)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060074056A1,Nc1c(Cl)ncnc1C#Cc1ccccc1>>Clc1ncnc2cc(-c3ccccc3)[nH]c12,,CN1CCCC1=O,,,,val
US20040014962A1,CC(C)(C)[Si](OC1CN(c2nc(C(=O)OCc3ccc([N+](=O)[O-])cc3)cs2)C1)(c1ccccc1)c1ccccc1>>O=C(OCc1ccc([N+](=O)[O-])cc1)c1csc(N2CC(O)C2)n1,,C1CCOC1,,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US04297129,CN(C)C=O.C[Si](C)(C)Oc1cnnc(O[Si](C)(C)C)n1.ClC1CCCCO1>>O=c1cnn(C2CCCCO2)c(=O)n1C1CCCCO1,,CN(C)C=O,,,,val
US20150218160A1,CCI.CCOC(C)=O.O=C(O)Cc1ccc(S)cc1>>CCOC(=O)Cc1ccc(SCC)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20150080364A1,Clc1ccc(CN2CCNCC2)c(N2CCn3ncnc3C2)c1.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O>>O=C(ON1C(=O)CCC1=O)N1CCN(Cc2ccc(Cl)cc2N2CCn3ncnc3C2)CC1,,CC#N,,CCN(CC)CC,,val
US20140031336A1,CCOC(=O)Cc1ccc(-c2ccc3c(c2)[C@H](Nc2ccc(C#N)cn2)C[C@H](C)N3C(C)=O)cc1>>CC(=O)N1c2ccc(-c3ccc(CC(=O)O)cc3)cc2[C@H](Nc2ccc(C#N)cn2)C[C@@H]1C,,CO,,[Li+].[OH-],,val
US20060052378A1,O=C(O)C(CCc1ccsc1)C(=O)O>>O=C(O)CCCc1ccsc1,,COCCOCCOC,,[NH4+].[OH-],,val
US20140243283A1,CC(=O)OC[C@H]1O[C@H](c2cccc(C#C[C@H]3O[C@H](COCc4ccccc4)[C@@H](OCc4ccccc4)[C@H](OCc4ccccc4)[C@@H]3OCc3ccccc3)c2)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@H](c2cccc(C#C[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)c2)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,CC#N,,C[Si](C)(C)I,,val
US20140094445A1,COC(=O)c1cccc(S(=O)(=O)N2CCC(C)CC2)c1.NN>>CC1CCN(S(=O)(=O)c2cccc(C(=O)NN)c2)CC1,,CO,,,,val
US20150342185A1,CI.COc1cccc(Cl)c1C1C(=O)C2CCC(C2)C1=O>>COC1=C(c2c(Cl)cccc2OC)C(=O)C2CCC1C2,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060148858A1,C#CCCCCO.ON=C(Cl)c1ccc(C(F)(F)F)cc1>>OCCCCc1cc(-c2ccc(C(F)(F)F)cc2)no1,,C1CCOC1,,CCN(CC)CC,Cl,val
US05919803,CI.O=Cc1cc(-n2nnnc2C(F)(F)F)ccc1O>>COc1ccc(-n2nnnc2C(F)(F)F)cc1C=O,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070281933A1,N#Cc1ccc(S(=O)(=O)Cl)cc1.NC(=O)c1cc(-c2ccccc2)cc2c(C3CCNCC3)n[nH]c12>>N#Cc1ccc(S(=O)(=O)N2CCC(c3n[nH]c4c(C(N)=O)cc(-c5ccccc5)cc34)CC2)cc1,CN(C)c1ccncc1,,,CCN(C(C)C)C(C)C,Cl,val
US20030236250A1,C=O.COC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>COC(=O)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CS(C)=O,,O,O=C([O-])O.[Na+],val
US20120157436A1,O=C(Cl)c1ccc(Cl)c(F)c1Cl.c1cnn(-c2nnc3n2CCNC3)c1>>O=C(c1ccc(Cl)c(F)c1Cl)N1CCn2c(nnc2-n2cccn2)C1,,CCOC(C)=O,ClCCl,CCN(CC)CC,O=C([O-])O.[Na+],val
US20150045327A1,CC(=O)Oc1ccccc1C(=O)Nc1sc2c(c1C(N)=O)CC(C)(C)OC2(C)C>>CC1(C)Cc2c(sc(NC(=O)c3ccccc3O)c2C(N)=O)C(C)(C)O1,,C1COCCO1,CO,O=C([O-])[O-].[K+].[K+],,val
US20160137672A1,CCc1c(C)nc(-c2ccc(Cl)s2)nc1Nc1ccc(C/C(=N\C(=O)Oc2ccccc2)NO)cc1>>CCc1c(C)nc(-c2ccc(Cl)s2)nc1Nc1ccc(Cc2noc(=O)[nH]2)cc1,,Cc1ccccc1,,,,val
US20120015962A1,Nc1[nH]ncc1C(=O)O.O=CC(Br)C=O>>O=C(O)c1cnn2cc(Br)cnc12,,Cl,,,,val
US20130225588A1,COC(=O)Cc1cc2ccc(F)cc2c(B2OC(C)(C)C(C)(C)O2)c1C.Clc1ccc(Sc2ccc(Br)cc2)c(Cl)c1>>COC(=O)Cc1cc2ccc(F)cc2c(-c2ccc(Sc3ccc(Cl)cc3Cl)cc2)c1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])O.[Na+],val
US20140364414A1,CC(C)(C)[Si](C)(C)OCCNS(=O)(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(/C=C/c4ccc5ccccc5n4)cn23)cc1>>O=S(=O)(NCCO)c1ccc(-c2cnc(N3CCOCC3)c3nc(/C=C/c4ccc5ccccc5n4)cn23)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100311966A1,CCCCOC(=O)C(=O)C(Br)CCC.CO[C@@H]1CN(C(N)=O)CC[C@@H]1NC(=O)OCc1ccccc1>>CCCc1oc(N2CC[C@H](NC(=O)OCc3ccccc3)[C@H](OC)C2)nc1C(=O)OCC,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20090042841A1,CCOC(=O)c1ccncc1.O=[N+]([O-])c1cccnc1Cl>>CCOC(=O)C1CCN(c2ncccc2[N+](=O)[O-])CC1,,CCCCO,,O,O=C([O-])[O-].[K+].[K+],val
US20050256078A1,BrC(Br)(Br)Br.CCc1c(C)c2c(c(OCC[Si](C)(C)C)c1CC=C(C)CO)C(=O)OC2>>CCc1c(C)c2c(c(OCC[Si](C)(C)C)c1CC=C(C)CBr)C(=O)OC2,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04665078,Cc1ccc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)cn1.NCCCCc1ncc(Br)cc1N>>Cc1ccc(Cc2cnc(NCCCCc3ncc(Br)cc3N)[nH]c2=O)cn1,,c1ccncc1,,,,val
US09266853B2,CC#CCBr.COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C>>CC#CCOc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)OC)cc1,,CCOC(C)=O,CN(C)C=O,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20090054427A1,COCC(C)(C)c1cccc(C2OCCO2)c1>>COCC(C)(C)c1cccc(C=O)c1,,C1CCOC1,,Cl,,val
US20130022594A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1cc(C2=CCNCC2)ccc1N>>COc1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)ccc1N,,CO,,,,val
US07553969B1,CONC(=O)[C@H](Cc1ccc(O)c(C(C)(C)C)c1)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)OC(C)(C)C>>CONC(=O)[C@H](Cc1ccc(O)c(C(C)(C)C)c1)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](N)Cc1ccc(F)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20090163471A1,COC(=O)c1cc(N)c(C(N)=O)cc1C>>Cc1cc(C(N)=O)c(N)cc1C(=O)O,,CO,,Cl,[Na+].[OH-],val
US20120309750A1,CCNC(=O)c1noc(-c2cc(C(C)C)c(OCc3ccccc3)cc2OCc2ccccc2)c1-c1cc(CO)no1>>CCNC(=O)c1noc(-c2cc(C(C)C)c(OCc3ccccc3)cc2OCc2ccccc2)c1-c1cc(C=O)no1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20140296202A1,COC(=O)c1c(F)cc(OCC[C@@H]2C[C@@H]2C2CCN(CC(F)(F)F)CC2)cc1F>>O=C(O)c1c(F)cc(OCC[C@@H]2C[C@@H]2C2CCN(CC(F)(F)F)CC2)cc1F,,CCOC(C)=O,CO,Cl,[Na+].[OH-],val
US20160200674A1,CC(C)CN(CC(C)C)c1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1NC(=O)Oc1ccc([N+](=O)[O-])cc1.Nc1ncccn1>>CC(C)CN(CC(C)C)c1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1NC(=O)Nc1ncccn1,,C1CCOC1,,[H-].[Na+],,val
US20050009843A1,CC(C)c1csc(/C=C/c2ccn3c(=O)c(/C=C/C(=O)OC(C)(C)C)c(N4CCOCC4)nc3c2)n1>>CC(C)c1csc(/C=C/c2ccn3c(=O)c(/C=C/C(=O)O)c(N4CCOCC4)nc3c2)n1,,C1COCCO1,,Cl,,val
US03962325,CC(C)=CCC(C(=O)F)(C(=O)F)C(F)(F)F.NC(N)=O>>CC(C)=CCC1(C(F)(F)F)C(=O)NC(=O)NC1=O,,COCCOC,,c1ccncc1,,val
US04565816,CC(=O)Nc1cnc(N2CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1NC(C)=O>>Cc1nc2cnc(N3CCN(CCCC(=O)c4ccc(F)cc4)CC3)cc2[nH]1,,O,,[Na+].[OH-],,val
US20140228343A1,CN(C)C=C1CCN(C(=O)OC(C)(C)C)CC1=O.NN>>CC(C)(C)OC(=O)N1CCc2cn[nH]c2C1,,CCO,,O,,val
US20030018046A1,CCOC(=O)Cc1cccnc1COC(C)=O>>CCOC(=O)Cc1cccnc1CO,,CCO,,[K+].[OH-],,val
US20150232452A1,CC(C)(C)c1ccc(N=C=O)cc1.CCn1cc(-c2cccc(N)c2)c(-c2ccncc2)n1>>CCn1cc(-c2cccc(NC(=O)Nc3ccc(C(C)(C)C)cc3)c2)c(-c2ccncc2)n1,,ClCCl,,,,val
US20060069085A1,CCOC(=O)c1nn(-c2ccccc2)c(C(=O)Nc2ccccc2)c1CCO.CS(=O)(=O)Cl>>CCOC(=O)c1nn(-c2ccccc2)c(C(=O)Nc2ccccc2)c1CCOS(C)(=O)=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04883815,CC(=O)NCCCC(=O)c1ccc(Cl)cc1CCC(=O)O.NC(=O)CO>>CC(=O)NCCCC(=O)c1ccc(Cl)cc1CCC(=O)OCC(N)=O,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20050192418A1,CC(C)(C)C1=CC=CC1.CC(C)=O>>CC(C)=C1C=CC(C(C)(C)C)=C1,,CCOCC,,CCO,[K+].[OH-],val
US20020016337A1,Nc1ccccc1.O=CC1CCCCN(C(=O)OCc2ccccc2)C1>>O=C(OCc1ccccc1)N1CCCCC(CNc2ccccc2)C1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US05721234,CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.NC1Cc2ccc3[nH]c(=O)c(=O)[nH]c3c2C1>>CC(C)(C)OC(=O)N1CCC(C(=O)NC2Cc3ccc4[nH]c(=O)c(=O)[nH]c4c3C2)CC1,,C1CCOC1,,Cl,O=C(n1ccnc1)n1ccnc1,val
US20140228582A1,Nc1ccc(C[C@H]2COC(=O)N2)cc1.O=N[O-]>>NNc1ccc(C[C@H]2COC(=O)N2)cc1,,Cl,O,[Na+].[OH-],,val
US20150241779A1,CC(=O)OC(C)=O.COc1ccc(C(=O)c2ccc(OCCO)cc2)c(OC)c1>>COc1ccc(C(=O)c2ccc(CCOC(C)=O)cc2)c(OC)c1,,C1CCOC1,,CCN(CC)CC,O,val
US20080194549A1,CC(C)CN(C[C@@H]1CNC[C@H]1C(C)(C)O[SiH2]C(C)(C)C)S(=O)(=O)c1ccccc1>>CC(C)CN(C[C@@H]1CNC[C@H]1CO)S(=O)(=O)c1ccccc1,,O,,CC#N,CC#N,val
US20110015175A1,COc1cc([N+](=O)[O-])c(F)cc1F.Cc1nc[nH]n1>>COc1cc([N+](=O)[O-])c(F)cc1-n1cnc(C)n1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US05849759,COc1ccc2nc(C(C)C)[nH]c2c1.O=[N+]([O-])O>>COc1ccc2nc(C(C)C)[nH]c2c1[N+](=O)[O-],,O=C(O)C(F)(F)F,,CO,ClCCl,val
US04005208,CC(=O)OC1c2ccccc2Oc2ccccc21.CCN1CCC(N)C1>>CCN1CCC(NC2c3ccccc3Oc3ccccc32)C1,,Cc1ccccc1,,,,val
US20130316943A1,COC(=O)C1=C(C(=O)OC)[C@@H]2C=C[C@H]1N2C(=O)OC(C)(C)C>>COC(=O)C1C(C(=O)OC)[C@@H]2CC[C@H]1N2C(=O)OC(C)(C)C,O=[Pt]=O,CO,,,,val
US20060178532A1,CC(C)NNC(=O)c1ccccc1.O=C(O)COc1ccc(F)cc1Br>>CC(C)N(NC(=O)c1ccccc1)C(=O)COc1ccc(F)cc1Br,,CN(C)C=O,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20050187298A1,CC(C)(C#N)c1cccc(Br)c1.CCO.O=S(=O)(O)O>>CCOC(=O)C(C)(C)c1cccc(Br)c1,,O,,,,val
US20090192163A1,CC[Zn]CC.O=C(O)Cc1cc(Oc2ccc(S(=O)(=O)c3ccccc3)cc2F)cc(OS(=O)(=O)C(F)(F)F)c1>>CCc1cc(CC(=O)O)cc(Oc2ccc(S(=O)(=O)c3ccccc3)cc2F)c1,,Cc1ccccc1,,,,val
US20100041719A1,CON(CCC(=O)c1ccccc1)C(=O)OC(C)(C)C.NNC(=S)c1cc(F)ccc1F>>CON(CCC1(c2ccccc2)NN=C(c2cc(F)ccc2F)S1)C(=O)OC(C)(C)C,,CCO,,,,val
US06825344B2,C=CCB1OC(C)(C)C(C)(C)O1.O=CC1=CS[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)OC(c1ccccc1)c1ccccc1>>C=CCC(O)C1=CS[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)OC(c1ccccc1)c1ccccc1,,Cc1ccccc1,,,,val
US20160009688A1,CN(C)c1ccc(C(=O)N2CCC(c3ccc(-c4cnn(C)c4)cc3)CC2)cc1N.O=C(Cl)C1CC1>>CN(C)c1ccc(C(=O)N2CCC(c3ccc(-c4cnn(C)c4)cc3)CC2)cc1NC(=O)C1CC1,,ClCCl,,CCN(CC)CC,,val
US20040063704A1,CC(=O)OC(C)=O.COc1cccc(N)c1C=O.c1ccncc1>>COc1cccc2nc(C)ncc12,,Cc1ccccc1,,,,val
US06265434B1,CC(C)(C)[Si](C)(C)OC[C@H]1CN(C(C(=O)O)c2ccccc2Cl)C[C@@H]1c1ccccc1.COc1ccc(CCl)cc1>>COc1ccc(COC(=O)C(c2ccccc2Cl)N2C[C@H](c3ccccc3)[C@@H](CO[Si](C)(C)C(C)(C)C)C2)cc1,,CCOCC,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140045819A1,O=C(O)C(F)(F)Cl.Oc1c(Br)cncc1Br>>FC(F)Oc1ccncc1Br,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110144105A1,CC1(C)OCC(Cc2cnc3c(c2)cc(C(=CC2CCCC2)c2ccc(S(C)(=O)=O)cc2)n3S(=O)(=O)c2ccccc2)O1>>CC1(C)OCC(Cc2cnc3[nH]c(C(=CC4CCCC4)c4ccc(S(C)(=O)=O)cc4)cc3c2)O1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US03943130,CI.O=C(O)C(O)c1ccccc1.S=C=S>>CSC(=S)OC(C(=O)O)c1ccccc1,,CS(C)=O,,[K+].[OH-],,val
US20090149439A1,CN(C)C=O.Cc1cc(Br)ncc1C(Sc1ccccc1)c1cc(F)ccc1F>>Cc1cc(C=O)ncc1C(Sc1ccccc1)c1cc(F)ccc1F,,Cc1ccccc1,,O,[Li]CCCC,val
US20140162997A1,CCOC(=O)CC(=O)c1ccc(Cl)cc1.COc1ccccc1NNC(C)=O>>COc1ccccc1-n1[nH]c(=O)cc1-c1ccc(Cl)cc1,,ClCCCl,,ClP(Cl)Cl,,val
US20040121989A1,CCCCc1n[nH]c(CCC(C)C)n1.COC(=O)c1ccccc1-c1ccc(CBr)cc1>>CCCCc1nc(CCC(C)C)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)n1,,CN(C)C=O,CO,[H][H],[H-].[Na+],val
US20070244131A1,CC(C)(C(=O)O)c1cccc(B(O)O)c1.Cc1nc(Cl)cc(NCc2cc3ccccc3s2)n1>>Cc1nc(NCc2cc3ccccc3s2)cc(-c2cccc(C(C)(C)C(=O)O)c2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120225857A1,CO.N.O=C([O-])c1sccc1CBr>>COC(=O)c1sccc1CN,,CO,,CN(C)C=O,,val
US20050192338A1,CCCN(CCC)CCc1ccccc1CC#N.O=S(=O)(O)O>>CCCN(CCC)CCc1ccccc1CC(=O)O,,O,,[Na+].[OH-],,val
US20040176308A1,CC(=O)OC[C@H]1O[C@@H](Oc2nn(CCO)c(C(C)C)c2Cc2ccccc2OCc2ccccc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(C)c1c(Cc2ccccc2OCc2ccccc2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1CCO,,CO,,C[O-].[Na+],,val
US20040142980A1,OCc1c[nH]c(-c2ccccc2Cl)n1>>O=Cc1c[nH]c(-c2ccccc2Cl)n1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20080207699A1,CNC(=O)c1cc(Oc2ccc(N)cc2)ccn1.Cc1ccc(-n2nc(-c3ccco3)cc2N)cc1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(-c4ccco4)nn3-c3ccc(C)cc3)cc2)ccn1,,CO,ClCCl,,,val
US20150011532A1,CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)O.CCOC(=O)C(N)=NN>>CCOC(=O)C(N)=NNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040132727A1,COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.O=C(N=C=S)c1ccccc1Cl>>COc1cc2ncnc(Oc3ccc(NC(=S)NC(=O)c4ccccc4Cl)cc3)c2cc1OC,,Cc1ccccc1,,CCO,,val
US20030092748A1,CN(C)[SH](=O)=O.Cc1ccccc1.O=[N+]([O-])O>>CN(C)[SH](=O)=O.Cc1ccccc1[N+](=O)[O-],,O=S(=O)(O)O,,O,,val
US20090286790A1,CCC1CC(=O)CCN1C(=O)OC(C)(C)C.Nc1ccc(Br)cc1>>CCC1CC(Nc2ccc(Br)cc2)CCN1C(=O)OC(C)(C)C,,ClCCCl,,CC(=O)O,[Na+].[OH-],val
US20160024021A1,CCN1CCN(c2ccc(Nc3ncc(/C=C/c4cc(OC)cc(C(=O)OC)c4)cn3)cc2)CC1>>CCN1CCN(c2ccc(Nc3ncc(CCc4cc(OC)cc(C(=O)OC)c4)cn3)cc2)CC1,[Pd],C1CCOC1,,,,val
US20100298301A1,CC1(C)OB(c2ccc(N)cc2)OC1(C)C.CN(C)CCCl>>CN(C)CCNc1ccc(B2OC(C)(C)C(C)(C)O2)cc1,,CC#N,,Cl,[I-].[K+],val
US20060094714A1,O=C(Cl)C(=O)Cl.O=c1cc(O)c2cccnc2n1-c1cccc(C(F)(F)F)c1>>O=c1cc(Cl)c2cccnc2n1-c1cccc(C(F)(F)F)c1,,ClCCl,,,,val
US06339154B1,CCCCCCCCCCCCCCCCCCN=C=O.O=C(CCc1ccccc1O)NCCCN1CCOCC1>>CCCCCCCCCCCCCCCCCCNC(=O)Oc1ccccc1CCC(=O)NCCCN1CCOCC1,,ClCCl,,CCN(CC)CC,,val
US20120330027A1,O=C(Cl)c1ccccc1.[C-]#[N+]C.[N-]=[N+]=[N-]>>Cn1nnnc1C(=O)c1ccccc1,,CC#N,CCOC(C)=O,O,,val
US20130045942A1,Cc1ccc(C=NO)cc1.Cl>>Cc1ccc(CN)cc1.Cl,[Pd],CCO,,,,val
US20120010182A1,COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(F)cc2F)c(OC)c1.Oc1cc(Cl)c(-c2cccc(F)c2)cc1-c1ccnnc1>>COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3cc(Cl)c(-c4cccc(F)c4)cc3-c3ccnnc3)cc2F)c(OC)c1,,CCOC(C)=O,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US20080214641A1,CON(C)C(=O)[C@H](C)NC(=O)OC(C)(C)C.COc1cccc([Mg]Br)c1>>COc1cccc(C(=O)[C@H](C)NC(=O)OC(C)(C)C)c1,,C1CCOC1,,,,val
US20090069502A1,C=C[Mg]Br.CCO[Si](C)(C)CCCCBr>>C=C[Si](C)(C)CCCCBr,,C1CCOC1,,,,val
US20090291917A1,CC1(C)OB(c2ccc(Oc3ccc(C=O)cc3)cc2COC2CCCCO2)OC1(C)C>>O=Cc1ccc(Oc2ccc3c(c2)COB3O)cc1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20140174650A1,C1CCOC1.O=C=S.OCc1ccccc1>>CSC(=O)OCc1ccccc1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US05317016,COC(=O)[C@@H]1C[C@@H](OS(C)(=O)=O)CN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1CO,,C1CCOC1,,CO,[BH4-].[Na+],val
US20100160308A1,COC(OC)c1ccc([N+](=O)[O-])c(Nc2nc(-c3ccccc3C(F)(F)F)c(C(N)=O)s2)c1>>NC(=O)c1sc(Nc2cc(C=O)ccc2[N+](=O)[O-])nc1-c1ccccc1C(F)(F)F,,CC#N,,Cl,,val
US20160120841A1,COC(=O)C1CC2(C1)CC(N)c1ccc(OC)cc1O2.O=C(O)C1(c2ccc3c(c2)OC(F)(F)O3)CC1>>COC(=O)C1CC2(C1)CC(NC(=O)C1(c3ccc4c(c3)OC(F)(F)O4)CC1)c1ccc(OC)cc1O2,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120270875A1,CCOC(=O)c1c(C)nc(NC/C=C/B2OC(C)(C)C(C)(C)O2)nc1C.Cc1ccc(Br)cc1O>>CCOC(=O)c1c(C)nc(NC/C=C/c2ccc(C)c(O)c2)nc1C,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20040097731A1,CCOC(=O)Cl.O=Cc1ccc(N2CCNCC2)cc1Cl>>CCOC(=O)N1CCN(c2ccc(C=O)c(Cl)c2)CC1,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20150152108A1,FC(F)(F)c1cccc(-c2ccc3c(n2)N[C@H]2CCN3C2)c1.O=C(Nc1cc(-c2cnco2)cc(-c2cnco2)c1)Oc1ccccc1>>O=C(Nc1cc(-c2cnco2)cc(-c2cnco2)c1)N1c2nc(-c3cccc(C(F)(F)F)c3)ccc2N2CC[C@H]1C2,CN(C)c1ccncc1,CC#N,,,,val
US04532243,CCc1c(C)nc(N)nc1SC.O=C(CBr)C(=O)c1ccccc1>>CCc1c(SC)nc2nc(C(=O)c3ccccc3)cn2c1C,,CCOCC,,,,val
US20140187545A1,C1COCCN1.Oc1cc(Cl)nc2c(Cc3cccc(Cl)c3Cl)c(C(F)(F)F)nn12>>Oc1cc(N2CCOCC2)nc2c(Cc3cccc(Cl)c3Cl)c(C(F)(F)F)nn12,,CCO,CCOC(C)=O,,,val
US20090163533A1,CCCn1nc(C(N)=O)cc1CC1CCOCC1>>CCCn1nc(C#N)cc1CC1CCOCC1,,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20140031342A1,ClCCCBr.Oc1ccc(OC(F)(F)F)cc1>>FC(F)(F)Oc1ccc(OCCCCl)cc1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US04367238,CCCCCCCC(C#N)(C(=O)OCC)c1cccc(Oc2ccccc2C)c1OC>>CCCCCCCC(C(=O)O)c1cccc(Oc2ccccc2C)c1O,,CC(=O)O,,I,,val
US20040133008A1,NCCn1cccn1.O=[N+]([O-])c1ccc(Cl)nc1>>O=[N+]([O-])c1ccc(NCCn2cccn2)nc1,,CN(C)C=O,,CCN(CC)CC,,val
US20110230458A1,COC(=O)Cc1ccc(O)cc1.OC1CCCCC1>>COC(=O)Cc1ccc(OC2CCCCC2)cc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100298321A1,CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](C#N)CC1>>N#C[C@@H]1CC[C@@H](CN)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150031668A1,COC(=O)c1ccc(C(=O)N[C@]2(c3ccc(OC(F)(F)F)c(F)c3)CCOc3cccnc32)cc1O>>O=C(N[C@]1(c2ccc(OC(F)(F)F)c(F)c2)CCOc2cccnc21)c1ccc(C(=O)O)c(O)c1,,CO,,[Na+].[OH-],,val
US05721103,CC(C=CC=C(C)c1cc(C(C)(C)C)cc(C(C)(C)C)c1)=CC(=O)O>>CC(/C=C/CC(C)c1cc(C(C)(C)C)cc(C(C)(C)C)c1)=C\C(=O)O,,CO,,,,val
US20160024052A1,O=C(OCc1ccccc1)N1CCC(Cn2cnc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CC1>>c1cc2c(cc1-c1cnn(C3CCCCO3)c1)ncn2CC1CCNCC1,[Pd],CCO,ClCCl,CO,[H][H],val
US20120245161A1,COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)C(F)(F)F)ccc3F)CC2)c2c(N)cccc21.O=C(O)c1cnco1>>COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)C(F)(F)F)ccc3F)CC2)c2c(NC(=O)c3cnco3)cccc21,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120316161A1,CCCC(C(=O)OC)c1c(C)nc2cc(-c3ccccc3)nn2c1Cl.Cc1ccc(B(O)O)cc1>>CCCC(C(=O)OC)c1c(C)nc2ccnn2c1-c1ccc(C)cc1,,COCCOC,O,CCN(C(C)C)C(C)C,,val
US05614548,CCCCCCCCCCCCCCCCSCC(O)CO.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCCCCCCCCCCCCCSCC(O)COC(c1ccccc1)(c1ccccc1)c1ccccc1,,c1ccncc1,,,,val
US20100160303A1,CC(C)(O)c1ccc2c(c1)[nH]c1c(C(N)=O)ccc(Br)c12.OCCO>>CC(C)(OCCO)c1ccc2c(c1)[nH]c1c(C(N)=O)ccc(Br)c12,,O,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US06303649B1,CC(C)(C)[Si](Oc1cccc2c1CC[C@](O)(COC(=O)N(c1ccc(F)cc1)c1ccc(F)cc1)C2)(c1ccccc1)c1ccccc1>>O=C(OC[C@@]1(O)CCc2c(O)cccc2C1)N(c1ccc(F)cc1)c1ccc(F)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20120172366A1,FC(F)(F)c1cn2c(n1)CNCC2.O=C(CBr)c1ccccc1>>c1ccc(-c2cn3c(n2)CNCC3)cc1,O=[Pt]=O,CO,,CCO,,val
US20110201604A1,CO[C@@H]1CCCNC1.Cn1c(Nc2nc3ccc(C(F)(F)F)cc3s2)nc2cc(C(=O)NCC(=O)O)ccc21>>CO[C@@H]1CCCN(C(=O)CNC(=O)c2ccc3c(c2)nc(Nc2nc4ccc(C(F)(F)F)cc4s2)n3C)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110057182A1,CC1(C)c2cc(Br)ccc2-c2cc3c(cc21)C(=O)c1cc(Br)ccc1C3>>CC1(C)c2cc(Br)ccc2-c2cc3cc4ccc(Br)cc4cc3cc21,,CC(C)O,,[BH4-].[Na+],,val
US05767116,Clc1cnccn1.NCC1CCNCC1>>NCC1CCN(c2cnccn2)CC1,,CC(C)CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20080145372A1,CC(C)(C)OC(=O)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)C(F)(F)[C@@H]1OC(=O)OC(C)(C)C.Cn1c(CO)cnc1[N+](=O)[O-].O=C(Cl)Cl>>Cn1c(COC(=O)Nc2ccn([C@@H]3O[C@H](COC(=O)OC(C)(C)C)[C@@H](OC(=O)OC(C)(C)C)C3(F)F)c(=O)n2)cnc1[N+](=O)[O-],,ClCCl,,c1ccncc1,,val
US20020013328A1,CCc1[nH]n(-c2c(Cl)cc(Cl)cc2Cl)c2nc(Cc3ccc(Br)cc3)nc(=O)c1-2.COc1ccc(B(O)O)cc1>>CCc1[nH]n(-c2c(Cl)cc(Cl)cc2Cl)c2nc(Cc3ccc(-c4ccc(OC)cc4)cc3)nc(=O)c1-2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],val
US20100137368A1,CNC1CCN(Cc2cccc(C(F)(F)F)c2)CC1.N#Cc1ccnc(Cl)c1>>CN(c1cc(C#N)ccn1)C1CCN(Cc2cccc(C(F)(F)F)c2)CC1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20160264578A1,CNC.COc1cccc(-n2c(=O)c3c(CBr)c(-c4ccc([N+](=O)[O-])cc4)cn3n(Cc3c(F)cccc3F)c2=O)c1F>>COc1cccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc([N+](=O)[O-])cc4)cn3n(Cc3c(F)cccc3F)c2=O)c1F,,C1CCOC1,C1CCOC1,CCN(C(C)C)C(C)C,,val
US20160200704A1,CNc1cc2cn[nH]c2cc1F.O=C(O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1>>O=C(NCc1cc2cn[nH]c2cc1F)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1,,CN(C)C=O,,Cl,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050070582A1,Cc1cc(C)cc(Oc2ccc(-c3nnn[nH]3)cc2S(=O)(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1.Cl>>Cc1cc(C)cc(Oc2ccc(-c3nnn[nH]3)cc2S(=O)(=O)N2CCNCC2)c1.Cl,,C1COCCO1,,,,val
US20030232883A1,CC(C(=O)Cl)C(=O)Cl.Nc1ccc(OCc2cccc(F)c2)cc1C(F)(F)F.O=C([O-])O>>COC(=O)CC(=O)Nc1ccc(OCc2cccc(F)c2)cc1C(F)(F)F,,CCOC(C)=O,,Cl,,val
US20160221959A1,C/C(=C\[C@@H]1COC(C)(C)O1)CO.CC(=O)Cl>>CC(=O)OC/C(C)=C/[C@@H]1COC(C)(C)O1,,C1CCOC1,,O,,val
US20130310395A1,O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(-c2[nH]ncc2F)c1.O[C@@H]1CCNC1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2[nH]ncc2F)c1,,CC(C)O,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20020198221A1,C=C(C(=O)c1cccs1)N(C)C.NO>>c1csc(-c2ccno2)c1,,CO,,Cl,,val
US20130217664A1,CC(=O)Cl.CN(c1cc2c(cn1)ncn2C)c1ccc(C2CNC2)cc1F>>CC(=O)N1CC(c2ccc(N(C)c3cc4c(cn3)ncn4C)c(F)c2)C1,,ClCCl,,CCN(CC)CC,,val
US05656648,COc1cccc(OC)c1.O=C(Cl)CCc1ccccc1>>COc1ccc(C(=O)CCc2ccccc2)c(OC)c1,,ClC(Cl)(Cl)Cl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20100113462A1,CCOC(=O)C1(NC(=O)c2cccc(C)c2OC2CCC2)Cc2ccc(Cl)cc2C1>>Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(Cl)cc3C2)c1OC1CCC1,,CCO,,[K+].[OH-],,val
US20050049290A1,CC(C)CN(CC(C)C)C(=O)c1ccc(NCCCN(C)CCc2ccccn2)c([N+](=O)[O-])c1>>CC(C)CN(CC(C)C)C(=O)c1ccc(NCCCN(C)CCc2ccccn2)c(N)c1,[Pd],CCO,CCOC(C)=O,,,val
US20110230518A1,CC1CCCCN1c1ccc(-c2nc(-c3ccc4c(c3)CCN(C(=O)OC(C)(C)C)C4)no2)cc1C(F)(F)F.ClCCl>>CC1CCCCN1c1ccc(-c2nc(-c3ccc4c(c3)CCNC4)no2)cc1C(F)(F)F.Cl,,O=C(O)C(F)(F)F,,,,val
US20130131036A1,CC(C)(C)OC(=O)N1CC=C(C2(C#N)CCC2)C1>>CC(C)(C)OC(=O)N1CCC(C2(C#N)CCC2)C1,[Pd],CCO,,,,val
US05298655,CC(C)=CCC/C(C)=C/CC/C(C)=C/C=O.COP(C)(=O)OC>>COP(=O)(CC(O)/C=C(\C)CC/C=C(\C)CCC=C(C)C)OC,,C1CCOC1,,[Li]CCCC,O=C([O-])O.[Na+],val
US20150175530A1,C#C[Mg]Br.CON(C)C(=O)[C@@H](C)CO[Si](C)(C)C(C)(C)C>>C#CC(=O)[C@@H](C)CO[Si](C)(C)C(C)(C)C,,C1CCOC1,,CCOCC,,val
US20090227603A1,COc1cc([N+](=O)[O-])cc(S(C)(=O)=O)c1>>COC1=CC(N)(S(C)(=O)=O)CC=C1,[Zn],O,,CO,[Cl-].[NH4+],val
US04695573,COc1ccc(CNc2c3c(nc4ccccc24)CCCC3=O)cc1>>COc1ccc(CNc2c3c(nc4ccccc24)CCCC3O)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160237035A1,CCCN1C(=O)C2(CC2)c2ccccc21.O=[N+]([O-])O>>CCCN1C(=O)C2(CC2)c2cc([N+](=O)[O-])ccc21,,CC(=O)O,,,,val
US08129361B2,CC(C)(C)OC(=O)NC(CO)(CO)CCc1ccc(OCCCCCc2ccccc2)c(C(F)(F)F)c1.Cl>>Cl.NC(CO)(CO)CCc1ccc(OCCCCCc2ccccc2)c(C(F)(F)F)c1,,ClCCl,,C1COCCO1,,val
US20160024049A1,CN(C)C(=O)CCl.FC1(F)CNCCC1Oc1nccnc1-c1ccncc1>>CN(C)C(=O)CN1CCC(Oc2nccnc2-c2ccncc2)C(F)(F)C1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20040147525A1,C=CC(=O)CC1CCCN1C(=O)OC(C)(C)C>>O=C1CCN2CCCC2C1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20070167458A1,CCOC(=O)C1CCNCC1.FC(F)(F)c1ccc(Cl)nc1>>CCOC(=O)C1CCN(c2ccc(C(F)(F)F)cn2)CC1,,CS(C)=O,,CCN(CC)CC,,val
US20130274255A1,COc1ccc(-c2n[nH]c3c2Cc2sc(-c4ccc(N)nc4)cc2-3)cc1>>Nc1ccc(-c2cc3c(s2)Cc2c(-c4ccc(O)cc4)n[nH]c2-3)cn1,,ClCCl,,BrB(Br)Br,,val
US05223525,Nc1c(SC(F)(F)F)ncn1-c1c(Cl)cc(C(F)(F)F)cc1Cl.O=S(=O)(Cl)Cl>>Nc1c(SC(F)(F)F)nc(Cl)n1-c1c(Cl)cc(C(F)(F)F)cc1Cl,,ClCCl,,,,val
US20110312936A1,CCC(N)C1CCC2(CC1)OCCO2.N#CO[K]>>CCC(NC(N)=O)C1CCC2(CC1)OCCO2,,O,,Cl,,val
US20030092677A1,CC(C)c1ccc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2ccnc(C#N)c2)c1>>CC(C)c1ccc2c(c1)NC(=O)CC(c1ccnc(C#N)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US04372953,Cc1ncsc1C(=O)CCCCl.Cn1nnnc1S>>Cc1ncsc1C(=O)CCCSc1nnnn1C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110065702A1,C[Si](C)(C)CCOCn1nc(/C=C/c2cnccn2)c2ccc(/C=C3/C(=O)Nc4ccccc43)cc21>>O=C1Nc2ccccc2C1=Cc1ccc2c(/C=C/c3cnccn3)n[nH]c2c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04414390,COc1ccc(-c2cn3ccccc3n2)c2c1NC(=O)CC2.Cl.N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O>>COc1ccc(-c2cn3ccccc3n2)c2ccc(=O)[nH]c12.Cl.O,,CC(C)=O,,C1COCCO1,,val
US20120115846A1,COc1ccc(Cn2c(=O)c3cc(N4CC(OCc5ccccc5)C4)ccc3n(C3CCOCC3)c2=O)cc1OC>>COc1ccc(Cn2c(=O)c3cc(N4CC(O)C4)ccc3n(C3CCOCC3)c2=O)cc1OC,[Pd],CCO,,O=C[O-].[NH4+],,val
US05552409,CC(C(=O)O)C(=O)c1ccc(Cl)cc1.CC(C)(C)NN>>CC(C)(C)N1N=C(c2ccc(Cl)cc2)CCC1=O,,CCCCO,,Cl,CC(=O)[O-].[Na+],val
US20140243338A1,COc1cccc(CN)c1.Cc1cc(C(=O)O)ccc1Br>>COc1cccc(CNC(=O)c2ccc(Br)c(C)c2)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060276520A1,O=C1CSC(=S)N1Cc1ccccc1.O=Cc1ccc(-c2cccc(C(F)(F)F)c2)o1>>O=C1/C(=C\c2ccc(-c3cccc(C(F)(F)F)c3)o2)SC(=S)N1Cc1ccccc1,,Cc1ccccc1,,C1CCNCC1,,val
US20080146637A1,CCOC(=N)CBr.CS(=O)(=O)c1ccccc1-c1ccc(N)c(N)c1>>CS(=O)(=O)c1ccccc1-c1ccc2[nH]c(CBr)nc2c1,,CCO,,Cl,,val
US20080300242A1,COc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)c(C)cc1N.COc1ccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)cc1C(=O)Nc1c(F)cccc1F>>COc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)c(C)cc1Nc1nccc(-c2c(-c3ccc(OC)c(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1,,CC(C)O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04214890,CNc1nc(C)cc(SCCOC)n1.O=C=NS(=O)(=O)c1ccccc1[N+](=O)[O-]>>COCCSc1cc(C)nc(N(C)C(=O)NS(=O)(=O)c2ccccc2[N+](=O)[O-])n1,,ClCCl,,,,val
US20060148817A1,C=CCBr.CC(=O)Nc1cc(OCc2ccccc2)c(C(C)=O)cc1Br>>C=CCN(C(C)=O)c1cc(OCc2ccccc2)c(C(C)=O)cc1Br,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20090076147A1,CC(C)(COCc1ccccc1)C(=O)O.O=C(Cl)C(=O)Cl>>CC(C)(COCc1ccccc1)C(=O)Cl,CN(C)C=O,ClCCl,,,,val
US20060041146A1,CCOC(=O)c1csc(NC(=O)OC(C)(C)C)n1>>CC(C)(C)OC(=O)Nc1nc(C(=O)O)cs1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20120028919A1,COc1ccccc1-c1ccc2cnc(S(C)=O)nn12.Nc1ccc2[nH]ccc2c1>>COc1ccccc1-c1ccc2cnc(Nc3ccc4[nH]ccc4c3)nn12,,COCCO,,CCN(C(C)C)C(C)C,,val
US20050020585A1,Brc1ncn(-c2ccccn2)n1.OB(O)c1cccc(Cl)c1>>Clc1cccc(-c2ncn(-c3ccccn3)n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US05597918,CC(=O)Cl.O=C1CC2CCc3sccc3C2=NN1c1ccc(Cl)cc1>>CC(=O)c1cc2c(s1)CCC1CC(=O)N(c3ccc(Cl)cc3)N=C21,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080167378A1,CC(C)c1cccc(O)c1.O=Cc1ccccc1F>>CC(C)c1cccc(Oc2ccccc2C=O)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160009744A1,CC(C)(C)[Si](C)(C)OCc1cc(Sc2cccc(Cl)c2)c(Cl)s1>>OCc1cc(Sc2cccc(Cl)c2)c(Cl)s1,,C1CCOC1,,,,val
US20100234433A1,COC(=O)[C@@H](NC(=O)c1ccc(-c2ccc(OC)nc2)cc1N)[C@@H](C)OC(C)(C)C.COCc1cc(C)c(N=C=O)c(C)c1>>COCc1cc(C)c(NC(=O)Nc2cc(-c3ccc(OC)nc3)ccc2C(=O)N[C@H](C(=O)OC)[C@@H](C)OC(C)(C)C)c(C)c1,,c1ccncc1,,,,val
US20150038486A1,CN1CCN(S(=O)(=O)c2ccc(B(O)O)cc2)CC1.COc1cccc2c1nc(C(F)F)n2-c1nc(Cl)nc(N2CCOCC2)n1>>COc1cccc2c1nc(C(F)F)n2-c1nc(-c2ccc(S(=O)(=O)N3CCN(C)CC3)cc2)nc(N2CCOCC2)n1,Cl[Pd]Cl,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20120053175A1,Brc1cnc2ncn(-c3ccc4[nH]ccc4c3)c2n1.COc1cc(B(O)O)cc(OC)c1OC>>COc1cc(-c2cnc3ncn(-c4ccc5[nH]ccc5c4)c3n2)cc(OC)c1OC,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],,val
US20140155391A1,C=CCO.CS(=O)(=O)NCc1cc(C(=O)O)ccc1OCCN1CCOCC1>>C=CCOC(=O)c1ccc(OCCN2CCOCC2)c(CNS(C)(=O)=O)c1,,CC#N,CCOC(C)=O,Cl,O=C(n1ccnc1)n1ccnc1,val
US20020103247A1,BrCCCCBr.Oc1ccc2c(ccn2-c2ccc(F)cc2)c1>>Fc1ccc(-n2ccc3cc(OCCCCBr)ccc32)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06297258B1,COc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NCCCl>>COc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1N1CC1,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20120004476A1,Cc1ccc2c(c1)C(=O)OC2=O>>Cc1ccc(CO)c(CO)c1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US05364871,BrBr.CCOC(=O)c1nc(C(C)=O)cs1>>CCOC(=O)c1nc(C(=O)CBr)cs1,,CO,,,,val
US05541286,CC(C)(C)OC(=O)NCCCc1ccccc1OCc1ccccc1>>CC(C)(C)OC(=O)NCCCc1ccccc1O,[Pd],CCO,,[H][H],,val
US20010021739A1,C=C(C)C(=O)Cl.CCCCCCCC/C=C\CCCCCCCCO>>C=C(C)C(=O)OCCCCCCCC/C=C\CCCCCCCC,,ClCCl,,CCN(CC)CC,,val
US05308854,BrCc1ccc2ccccc2c1.CCc1cc(N)c(=O)[nH]c1C>>O=c1[nH]cccc1NCc1cccc2ccccc12,,CC#N,,CCN(CC)CC,,val
US20150175558A1,CC(C)I.O=[N+]([O-])c1ccccc1O>>CC(C)Oc1ccccc1[N+](=O)[O-],,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130289238A1,COc1nn2cc(-c3cc4c(O)cccc4o3)nc2s1.OCc1csc(-c2ccccc2)n1>>COc1nn2cc(-c3cc4c(OCc5csc(-c6ccccc6)n5)cccc4o3)nc2s1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160237090A1,CC(C)(C)OC(=O)N1CCn2ncc(C3=CCCC3)c2C1>>CC(C)(C)OC(=O)N1CCn2ncc(C3CCCC3)c2C1,[Pd],CO,,,,val
US20150291533A1,CI.COC(=O)C1CCN(S(=O)(=O)c2ccc(C)cc2)c2ccccc2C1=O>>COC(=O)C1(C)CCN(S(=O)(=O)c2ccc(C)cc2)c2ccccc2C1=O,,O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US05212169,COC(=O)C=Cc1ccncc1>>COC(=O)CCc1ccncc1,[Pd],CO,,,,val
US20120122840A1,Cc1cc(O)ccc1[N+](=O)[O-].ClCCN1CCOCC1>>Cc1cc(OCCN2CCOCC2)ccc1[N+](=O)[O-],,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060173019A1,COCCl.O=S(=O)(Nc1cc(Cl)cnc1Br)c1ccc(Cl)c(C(F)(F)F)c1>>COCN(c1cc(Cl)cnc1Br)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20130150364A1,CC1(C)CO1.NC12CCC(CNc3nc(N4CCOCC4)cc(-n4c(C(F)F)nc5ccccc54)n3)(CC1)CC2>>CC(C)(O)CNC12CCC(CNc3nc(N4CCOCC4)cc(-n4c(C(F)F)nc5ccccc54)n3)(CC1)CC2,,CCO,,CCN(C(C)C)C(C)C,,val
US20140206682A1,Cc1ccc2ncc(C(=O)O)n2c1.Nc1cc(C(=O)N[C@@H]2c3cc(F)ccc3C[C@@H]2O)ccc1F>>Cc1ccc2ncc(C(=O)Nc3cc(C(=O)N[C@@H]4c5cc(F)ccc5C[C@@H]4O)ccc3F)n2c1,,CN(C)C=O,ClCCl,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20050245529A1,C/C(=C\[C@@H](C)NC(=O)OC(C)(C)C)c1ccc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)cc1>>C/C(=C\[C@@H](C)N)c1ccc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)cc1,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20140171423A1,Brc1cnc(C2CC2)cn1.O=C1CCN(c2ccc(C(F)(F)F)cn2)C[C@@H]2C[C@H](O)CN12>>O=C1CCN(c2ccc(C(F)(F)F)cn2)C[C@@H]2C[C@H](Oc3cnc(C4CC4)cn3)CN12,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US08129361B2,Cc1ccc(C)c(CCCO)c1.O=C1CCC(=O)N1Br>>Cc1ccc(C)c(CCCBr)c1,,ClCCl,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030220368A1,COc1ncccc1CN1CCCCC1CCO>>COc1ncccc1CN1CCCCC1CC=O,,CS(C)=O,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20160176882A1,CO.O=Cc1c(F)ccc(F)c1Br>>COc1ccc(F)c(Br)c1C=O,,C1CCOC1,CO,CO[Na],,val
US20060142366A1,CCCCCCCCc1ccc(OCC(O)Cn2ccc3cc(C#N)ccc32)cc1.[OH-]>>CCCCCCCCc1ccc(OCC(O)Cn2ccc3cc(C(N)=O)ccc32)cc1,,CC(C)(C)O,O,Cl,,val
US20020040138A1,CC(C)(C)C(=O)Nc1ccc(Cl)cc1F.CCOC(=O)C(F)(F)F>>CC(C)(C)C(=O)Nc1c(F)cc(Cl)cc1C(=O)C(F)(F)F,,C1CCOC1,CCCCC,[Li]C(C)(C)C,,val
US20120022096A1,OC(CCl)CNc1ccccc1>>c1ccc(NCC2CO2)cc1,,C1COCCO1,CCOC(C)=O,[K+].[OH-],,val
US20140315934A1,CCOc1cc(F)c(Cn2nc(-c3ncc(OCCSC)c(Nc4ccncc4)n3)c(C)c2C2CC2)c(F)c1.O=C(OO)c1cccc(Cl)c1>>CCOc1cc(F)c(Cn2nc(-c3ncc(OCCS(C)=O)c(Nc4ccncc4)n3)c(C)c2C2CC2)c(F)c1,,ClC(Cl)Cl,ClCCl,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20060040918A1,CC(C)(C)OC(=O)N1CCc2ccc(O)cc2CC1.CNC(=O)c1ccc(Cl)nc1>>CNC(=O)c1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)CC3)nc1,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20130196998A1,CC(CN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12)C(=O)OC(C)(C)C.Cl>>CCc1ccc(Cl)c(COc2ccc3c(c2)OCC32CCN(CC(C)C(=O)O)CC2)c1Cl.Cl,,Cl,,C1COCCO1,,val
US20090203753A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OCCNCCCOCCc1ccccc1>>CC(C)(C)OC(=O)N(CCO)CCCOCCc1ccccc1,,ClCCl,,,,val
US05840727,CC(=O)c1ccc(OCCCBr)cc1C.Fc1ccc2c(C3CCNCC3)noc2c1>>CC(=O)c1ccc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1C,,CC#N,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20070249603A1,Fc1cccc2cccnc12.O=C1CCC(=O)N1I>>Fc1cccc2cc(I)cnc12,,CC(=O)O,,,,val
US20130102576A1,CC(C)(C)OC(=O)CN1C(=O)c2cccc(NS(C)(=O)=O)c2C1=O>>CS(=O)(=O)Nc1cccc2c1C(=O)N(CC(=O)O)C2=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070149561A1,O=C1CCC(=O)N1Br.O=[N+]([O-])c1ccc(-c2ccn[nH]2)cc1>>O=[N+]([O-])c1ccc(-c2n[nH]cc2Br)cc1,,CN(C)C=O,,,,val
US20090149501A1,CC1(C)OCC(CCO)O1.CS(=O)(=O)Cl>>CC1(C)OCC(CCOS(C)(=O)=O)O1,,C1CCOC1,,CCN(CC)CC,,val
US04851519,CCC(C(=O)Cl)c1ccccc1.CCc1cn([C@H]2C[C@H](O)[C@@H](CN)O2)c(=O)[nH]c1=O>>CCc1cn([C@H]2C[C@H](O)[C@@H](CNC(=O)C(CC)c3ccccc3)O2)c(=O)[nH]c1=O,,O,,[Na+].[OH-],,val
US20100063068A1,O=C(O)c1cccc(B(O)O)c1.O=[N+]([O-])c1cnccc1Cl>>O=C(O)c1cccc(-c2ccncc2[N+](=O)[O-])c1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US04780242,ClC(Cl)Cl.Oc1ccccc1F.[OH-]>>O=Cc1ccc(O)c(F)c1,,O,,O=S(=O)(O)O,,val
US20060148858A1,CCOC(=O)CCc1cn(-c2ccccn2)nc1OCC>>CCOc1nn(-c2ccccn2)cc1CCCO,,C1CCOC1,CCCCCC,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US20050033051A1,CCOC(=O)CC(COC(c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O>>O=c1ccn(C(CCO)COC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]1,,C1CCOC1,CC(C)(C)O,[BH4-].[Na+],,val
US06825191B2,CI.CN1CCN=C1c1ccc(CN2C(=O)CN(C(=O)c3ccc(Cl)cc3)Cc3ccccc32)cc1.O=C(O)C(F)(F)F>>CN1CC[N+](C)=C1c1ccc(CN2C(=O)CN(C(=O)c3ccc(Cl)cc3)Cc3ccccc32)cc1.O=C([O-])C(F)(F)F,,CN(C)C=O,,[H-].[Na+],,val
US06448205B1,CC(C)Sc1cnc(Cl)c(Cl)c1.O=C(OO)c1cccc(Cl)c1>>CC(C)S(=O)c1cnc(Cl)c(Cl)c1,,ClCCl,,,,val
US05739345,CI.OCc1nc2cccnc2[nH]1>>Cn1c(CO)nc2ncccc21,,CN(C)C=O,,[H-].[Na+],,val
US20140243349A1,BrCCBr.Oc1ccccc1S>>c1ccc2c(c1)OCCS2,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080293708A1,CC(C)(C)OC(=O)N1CCNCC1.CN1Cc2c(F)ccc([N+](=O)[O-])c2C1=O>>CN1Cc2c(N3CCN(C(=O)OC(C)(C)C)CC3)ccc([N+](=O)[O-])c2C1=O,,CS(C)=O,O,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US05753664,CCOC(=O)c1cccnc1C=O.CNN>>Cn1ncc2ncccc2c1=O,,CCO,,,,val
US20100216746A1,Cc1cc(Br)c(Cl)c(Oc2cc(Cl)cc(C#N)c2)c1F.O=C1CCC(=O)N1Br>>N#Cc1cc(Cl)cc(Oc2c(F)c(CBr)cc(Br)c2Cl)c1,,ClC(Cl)(Cl)Cl,,,,val
US05877199,CSc1c(CC(=O)OCc2ccccc2)cc(C)c2c3ccccc3n(Cc3ccccc3)c12>>CSc1c(CC(=O)O)cc(C)c2c3ccccc3n(Cc3ccccc3)c12,,CCO,,Cl,[Na+].[OH-],val
US20080227770A1,CCOC(=O)CC(=O)C[C@H]1O[C@H](c2cccc(OC)c2OC)c2cc(Cl)ccc2N(CC(C)(C)COC(C)=O)C1=O.O=CCCl>>COc1cccc([C@H]2O[C@H](Cc3occc3C(=O)O)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,O,val
US20070191604A1,C=C(C(=O)OC)C(F)(F)F.COCN(Cc1ccccc1)C[Si](C)(C)C>>COC(=O)C1(C(F)(F)F)CCN(Cc2ccccc2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090253677A1,CC1(C)CN(c2cc(F)ccc2C#N)S(=O)(=O)N1.CI>>CN1C(C)(C)CN(c2cc(F)ccc2C#N)S1(=O)=O,,CN(C)C=O,O,[H-].[Na+],,val
US20020111375A1,O=C1NC(=O)c2c1c1c3cc(F)c(F)cc3[nH]c1c1c2c2cc(F)c(F)cc2n1[C@@H]1O[C@H](CO)C(F)(F)[C@H](O)[C@H]1O>>O=C1NC(=O)c2c1c1c3cc(F)c(F)cc3[nH]c1c1c2c2cc(F)c(F)cc2n1[C@@H]1O[C@@H]2CO[C@H]([C@H]1O)C2(F)F,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050148621A1,NCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2.O=C(OCCc1c[nH]c2ccccc12)Oc1ccc([N+](=O)[O-])cc1>>O=C(NCCCCCCCNc1c2c(nc3ccccc13)CC(Cl)CC2)OCCc1c[nH]c2ccccc12,CN(C)c1ccncc1,,,,,val
US20140011845A1,BrCc1ccccc1.Cc1ccc(C)c(C2=C(O)C(CC3CCSCC3)NC2=O)c1>>Cc1ccc(C)c(C2=C(OCc3ccccc3)C(CC3CCSCC3)NC2=O)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150353489A1,CCCCCI.CCOC(=O)Cc1cccc2ccc(O)cc12>>CCCCCOc1ccc2cccc(CC(=O)OCC)c2c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20130131132A1,CCS(=O)(=O)NCc1ccc2c(c1)C(Cc1ccccc1)C(N)CC2.C[Si](C)(C)C#N.O=C1COC1>>CCS(=O)(=O)NCc1ccc2c(c1)C(Cc1ccccc1)C(NC1(C#N)COC1)CC2,,CCOC(C)=O,,,,val
US20010014694A1,CSc1nc(Oc2ccccc2)cc(Oc2ccccc2)n1.O=C=O>>CSc1nc(Oc2ccccc2)c(C(=O)O)c(Oc2ccccc2)n1,,C1CCOC1,,Cl,[Li]CCCC,val
US07026515B2,C[C@@H]1NC(NC(=O)OCc2ccccc2)OC1(O)c1ccc(F)cc1F>>C[C@H](NC(=O)OCc1ccccc1)C(=O)c1ccc(F)cc1F,,C1CCOC1,Cc1ccccc1,Cl,O,val
US20030191013A1,C[Si](C)(C)OCCCC1=CCc2ccccc21.[Li]CCCC>>C[Si](C)(C)OCCC[c-]1ccc2ccccc21.[Li+],,CCCCCC,CCOCC,,,val
US20050197350A1,CN(C)c1cc(N[C@@H]2CC[C@H](N)CC2)nc2ccccc12.O=C(Cl)c1cccnc1Oc1ccccc1>>CN(C)c1cc(N[C@@H]2CC[C@H](NC(=O)c3cccnc3Oc3ccccc3)CC2)nc2ccccc12.Cl,,ClC(Cl)Cl,,CCN(CC)CC,,val
US05476933,C=CC(C)=NO[Si](C)(C)C(C)(C)C.COC1=CC(=O)C=C(Br)C1=O>>COC1=CC(=O)c2ccc(C)nc2C1=O,,Clc1ccccc1,,,,val
US20090137557A1,CC/C(C(=O)NCCc1ccccc1F)=C(\C)N.O=C(O)c1cccc(F)c1O>>CC/C(C(=O)NCCc1ccccc1F)=C(\C)NC(=O)c1cccc(F)c1O,,C1CCOC1,CCOC(C)=O,ClCCCl,On1nnc2ccccc21,val
US20090093415A1,CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.c1cncc(C2CCCCN2)c1>>CC(=O)Nc1ccc(S(=O)(=O)N2CCCCC2c2cccnc2)cc1,,c1ccncc1,,,,val
US20060155128A1,CC(C)OC(=O)N1CCC(O)CC1.COc1c([N+](=O)[O-])ccnc1Cl>>COc1c(OC2CCN(C(=O)OC(C)C)CC2)ccnc1Cl,,C1COCCO1,,[H-].[Na+],,val
US20070254894A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.Nc1cccc2cccnc12>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)Nc1cccc2cccnc12,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20030220328A1,BrCc1ccccc1.CC(C)(C)OC(=O)N[C@@H](CO)C(=O)O>>CC(C)(C)OC(=O)N[C@@H](CO)C(=O)OCc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130190307A1,CC(C)(C)OC(=O)C(C#N)c1ccc([N+](=O)[O-])cn1>>N#CCc1ccc([N+](=O)[O-])cn1,,CCO,Cl,,,val
US20110190489A1,COc1ccc2c(c1)c(Br)nn2C.C[Sn](C)(C)[Sn](C)(C)C>>COc1ccc2c(c1)c([Sn](C)(C)C)nn2C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20080103202A1,CC(=O)C(=O)O.CCOC(=O)CN(C)C(=N)N>>CC(=O)C(=O)O.CCOC(=O)CN(C)C(=N)N,,O,,,,val
US20150225379A1,C=CCOC(=O)N(CC1(COc2ccc(F)cn2)CCN(CCC(=O)OC)CC1)[C@@H]1C[C@H]1c1ccccc1>>COC(=O)CCN1CCC(CN[C@@H]2C[C@H]2c2ccccc2)(COc2ccc(F)cn2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,CCNCC,,val
US04940710,CCn1cc(C(=O)O)c(=O)c2cc(F)c(Cl)cc21.Clc1ccc2oc(C3CNCCN3)cc2c1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(c4cc5cc(Cl)ccc5o4)C3)cc21,,c1ccncc1,,,,val
US05780642,CC(C)(N)CO.CCOC(CCn1ccnc1)OCC>>CC(C)(CO)NCCCn1ccnc1,,CC#N,,,,val
US04619924,CSCCSC(C)=O.O=C(OO)c1cccc(Cl)c1>>CC(=O)SCCS(C)=O,,ClCCl,,,,val
US20100130495A1,COc1cc(NC(=N)N)ccc1-n1cnc(C)c1.Cc1cc(C)n(C(C)C(=O)C2CN(C(=O)OC(C)(C)C)CCC2=O)n1>>COc1cc(Nc2nc3c(c(C(C)n4nc(C)cc4C)n2)CN(C(=O)OC(C)(C)C)CC3)ccc1-n1cnc(C)c1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20100216746A1,CCOC(=O)c1[nH]c(C(=O)O)cc1C.NCCO>>CCOC(=O)c1[nH]c(C(=O)NCCO)cc1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04426524,CC1CCCC(O)(c2ccsc2)C1>>CC1C=C(c2ccsc2)CCC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05750549,CO.Cc1nc2ccc(O)c(C=O)c2s1>>COc1ccc2nc(C)sc2c1C=O,,CO,c1ccccc1,C[Si](C)(C)C=[N+]=[N-],,val
US20140243315A1,CC(C)(C)[Si](C)(C)OC1CCC(O)(c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cnc(Cl)nc23)CC1>>CC(C)(C)[Si](C)(C)OC1CC=C(c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cnc(Cl)nc23)CC1,,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US20030008907A1,COc1ccc([N+](=O)[O-])c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1>>COc1ccc([N+](=O)[O-])c(NC(=O)OC(C)(C)C)c1,,CO,Cc1ccccc1,C[O-].[Na+],,val
US20130331372A1,C[C@@H]1NC(=O)O[C@@H]1c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cc1cc(Cl)nc(CBr)c1Br>>Cc1cc(Cl)nc(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)c1Br,,C1CCOC1,,[H-].[Na+],,val
US20070105900A1,CCOC(=O)c1n[nH]cc1[N+](=O)[O-].COc1ccc(CCl)cc1>>CCOC(=O)c1nn(Cc2ccc(OC)cc2)cc1[N+](=O)[O-],,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110034507A1,COC(=O)c1cccc(C(=O)n2ccc3cc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)ccc32)c1>>CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc2[nH]ccc2c1,,C1COCCO1,,[Li+].[OH-],,val
US20100099755A1,COS(=O)(=O)OC.Oc1ccc(C2OCCO2)cc1Br>>COc1ccc(C2OCCO2)cc1Br,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050101643A1,CCC[C@@H](C)[C@@H](C)[C@H](N)CC(=O)O>>CCC[C@@H](C)[C@@H](C)[C@H](N)CC(=O)O,,CO,,CCN(CC)CC,Cl,val
US04684654,NCCCc1ncc[nH]1.O=c1[nH]c2ccccc2c(=O)o1>>Nc1ccccc1C(=O)NCCCn1ccnc1,,Cc1ccccc1,,,,val
US05134142,CCOC(=O)C(=O)CC(=O)c1ccc(C)cc1.NNc1ccc(F)cc1>>CCOC(=O)c1cc(-c2ccc(C)cc2)n(-c2ccc(F)cc2)n1,,C1COCCO1,CCO,Cl,,val
US20080027065A1,C[C@H]1CNCCN1C(=O)OC(C)(C)C.O=[N+]([O-])c1ccc(CBr)cc1F>>C[C@H]1CN(Cc2ccc([N+](=O)[O-])c(F)c2)CCN1C(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05932599,CN.Nc1ccc(S(=O)(=O)Nc2cc(Cl)nc(N3CCC3)n2)cc1>>CNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(N2CCC2)n1,,CCO,,CCN(CC)CC,Cl,val
US03947456,COc1cccc(CNCC(O)c2cccc([N+](=O)[O-])c2)c1.Cl>>COc1cccc2c1C(c1cccc([N+](=O)[O-])c1)CNC2.Cl,,CCOC(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20030212092A1,O=[N+]([O-])c1cnc2ccccc2c1NCCOc1ccccc1>>Nc1cnc2ccccc2c1NCCOc1ccccc1,[Pt],CCOC(C)=O,,,,val
US08759539B2,Cc1cncc(C(=O)NC2CCC3C2CCN3C(=O)OC(C)(C)C)c1.O=C(O)C(F)(F)F>>Cc1cncc(C(=O)NC2CCC3NCCC32)c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20160137659A1,C1COCCO1.Cc1cc2c(cc1Br)OC1(CCNCC1)CC2=O>>Cc1cc2c(cc1Br)OC1(CCN(C)CC1)CC2=O,,C1COCCO1,,Cl,Cl,val
US09073925B2,CI.NNc1cccc(Br)c1>>CN(N)c1cccc(Br)c1,,C1CCOC1,,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20070105859A1,CCOC(=O)CCCBr.O=C1c2ccccc2C(=O)N1O>>CCOC(=O)CCCON1C(=O)c2ccccc2C1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,[Cl-].[NH4+],val
US04562210,CN(C)C(=O)Cl.NS(=O)(=O)c1ccccc1OC(Cl)=CCl>>CN(C)C(=O)NS(=O)(=O)c1ccccc1OC(Cl)=CCl,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US04071518,CNNCc1ccc(Cl)cc1.N#Cc1ccncc1>>Cn1nc(-c2ccc(Cl)cc2)nc1-c1ccncc1,,CO,,[Na],,val
US04124704,II.O=C(O)Cc1oc2cccc-2cc1-c1ccccc1>>O=C(O)CC1(I)OC2=CC=CC2=CC1c1ccccc1,,c1ccccc1,,,,val
US20100331335A1,Fc1ccc2cnccc2c1.O=C1CCC(=O)N1Br>>Fc1ccc2cnccc2c1Br,,O=S(=O)(O)O,,,,val
US05047534,CCCCC(=O)O.ClCc1ccccc1>>CCCC(Cc1ccccc1)C(=O)O,,C1CCOC1,,O,CC(C)[N-]C(C)C.[Li+],val
US20100069381A1,Br[Mg]c1cccs1.CON(C)C(=O)CCc1nnc(-c2ccc3c(c2)CCO3)o1>>O=C(CCc1nnc(-c2ccc3c(c2)CCO3)o1)c1cccs1,,C1CCOC1,,O,[Cl-].[NH4+],val
US20080153810A1,CNCCN(C)C.O=[N+]([O-])c1ccc2nn([N+](=O)[O-])cc2c1>>CN(C)CCN(C)c1n[nH]c2ccc([N+](=O)[O-])cc12,,C1CCOC1,,,,val
US20090197883A1,CC1(C)CC(c2ccccc2)(c2cc(OCc3ccc4ccccc4n3)ccc2C(=O)NN)C1.S=C(Cl)Cl>>CC1(C)CC(c2ccccc2)(c2cc(OCc3ccc4ccccc4n3)ccc2-c2n[nH]c(=S)o2)C1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20160024079A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(Br)c(C=O)c2cc[nH]c12>>Cc1cc(Br)c(C=O)c2ccn(C(=O)OC(C)(C)C)c12,CN(C)c1ccncc1,CC#N,,,,val
US20130267510A1,O=[N+]([O-])c1cnc(Oc2cccc3c2C2(CCO3)CC2)nc1>>Nc1cnc(Oc2cccc3c2C2(CCO3)CC2)nc1,[Fe],C1CCOC1,O,[Cl-].[NH4+],,val
US20090233915A1,NCCCNCc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O>>O=C(NOCCO)c1cc(CN2CCCNC2=O)c(F)c(F)c1Nc1ccc(I)cc1F,,C1CCOC1,CC#N,CCN(CC)CC,,val
US20150065482A1,CNC(=O)c1ccc2c(c1)c(C(=O)OC)nn2-c1cccc(C#C[C@]2(O)CCN(C)C2=O)c1.N>>CNC(=O)c1ccc2c(c1)c(C(N)=O)nn2-c1cccc(C#C[C@]2(O)CCN(C)C2=O)c1,,CO,,,,val
US20070037874A1,CC1(C)C=Cc2c(ccc(C=O)c2O)O1.O=C(Cl)c1ccccc1>>CC1(C)C=Cc2c(ccc(C=O)c2OC(=O)c2ccccc2)O1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100237283A1,CCC(CO)(CO)CO.CCCCC/C=C\C/C=C\CCCCCCCC(=O)O>>CCC(CO)(CO)CO.CCCCC/C=C\C/C=C\CCCCCCCC(=O)O,,O,,,,val
US05916786,N.O=C1OC[C@@H]2CCC[C@H]12>>NC(=O)[C@H]1CCC[C@H]1CO,,CCO,,CO,ClCCl,val
US05476876,COc1ccc(CSC(C)(C)CC(=O)c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1>>CC(C)(S)CC(=O)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20080280969A1,CC(C)(C)OC(=O)N1[C@H](C(N)=O)CC[C@H]1c1ccc(O)cc1.Fc1ccccc1CBr>>CC(C)(C)OC(=O)N1[C@H](C(N)=O)CC[C@H]1c1ccc(OCc2ccccc2F)cc1,,CC#N,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20140066424A1,CC(=N)N.NNC(=O)c1cc(-c2ccc(OC(F)(F)F)cc2)no1>>Cc1nc(-c2cc(-c3ccc(OC(F)(F)F)cc3)no2)n[nH]1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20150065522A1,CCc1c(C)[nH]c2c(C#N)cnn2c1=O.O/N=C(\Cl)c1ccccn1>>CCc1c(C)[nH]c2c(-c3nc(-c4ccccn4)no3)cnn2c1=O,,CC(C)=O,,CCN(CC)CC,,val
US20150299120A1,Cc1c(N2C(=O)N(C)C3(CCC(O)C3)C2=O)ccc(C#N)c1Cl>>Cc1c(N2C(=O)N(C)C3(CCC(=O)C3)C2=O)ccc(C#N)c1Cl,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20080039440A1,[N-]=[N+]=Nc1cc(Oc2ccc3c(c2)CCN3C(=O)Nc2cccc(C(F)(F)F)c2)ncn1>>Nc1cc(Oc2ccc3c(c2)CCN3C(=O)Nc2cccc(C(F)(F)F)c2)ncn1,[Pd],C1CCOC1,,,,val
US20070293516A1,NC(=O)CI.Nc1ncnc2[nH]nc(-c3ccc4ccccc4c3)c12>>NC(=O)Cn1nc(-c2ccc3ccccc3c2)c2c(N)ncnc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20050233988A1,BrBr.COC(=O)c1ccc(C)cc1C>>COC(=O)c1cc(Br)c(C)cc1C,,CCOCC,,[Al],,val
US20070185140A1,CC1Cc2ccccc2N1C.Clc1nc(Cl)c2[nH]cnc2n1>>Cc1cc2ccccc2n1-c1nc(Cl)nc2[nH]cnc12,,CCCCO,,,,val
US20040122098A1,CC(C)(C)O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@H](CCSSCC[C@@H](N)C(=O)O)C(=O)O>>CC(C)(C)OC(=O)N[C@H](CCSC(C)(C)C)C(=O)O,,N,,[Na],,val
US20140255381A1,CC(C)(NC(=O)CCl)c1cccc(Br)c1>>CC(C)(N)c1cccc(Br)c1.Cl,,CCO,,CC(=O)O,,val
US20100322880A1,CCCCCCCCN(CCCCCCCC)c1ccc(C(=O)c2ccccc2C(=O)O)c(O)c1.O=C1O[C@H]([C@@H](O)CO)C(O)=C1O>>CCCCCCCCN(CCCCCCCC)c1ccc(C(=O)c2ccccc2C(=O)OCC(O)C2OC(=O)C(O)=C2O)c(O)c1,,CC(C)=O,,,,val
US20040138286A1,CC(=O)Cl.Cc1c(O[C@@H]2CC[C@@H](N(C)C)CC2)ccc2[nH]ncc12>>CC(=O)n1ncc2c(C)c(O[C@@H]3CC[C@@H](N(C)C)CC3)ccc21,,CN(C)C=O,O,CCN(CC)CC,Cl,val
US20130252980A1,CCOC(=O)N1CCC(Oc2ncnc(Oc3cccc(/C=C4\SC(=O)NC4=O)c3)c2C)CC1.CI>>CCOC(=O)N1CCC(Oc2ncnc(Oc3cccc(/C=C4\SC(=O)N(C)C4=O)c3)c2C)CC1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US04939140,Cc1ccc2scnc2c1.O=C1CCC(=O)N1Br>>BrCc1ccc2scnc2c1,,ClC(Cl)(Cl)Cl,,,,val
US20070232627A1,O=C(Nc1ccc(F)c([N+](=O)[O-])c1)c1ccc(Br)s1.Oc1ccc(S)cc1>>O=C(Nc1ccc(Sc2ccc(O)cc2)c([N+](=O)[O-])c1)c1ccc(Br)s1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20130345194A1,CC(C)(C)OC(=O)N(C[C@@H]1CCCN1Cc1ccccc1)S(=O)(=O)N1CCN(c2ncnc3c2ccn3C(=O)OC(C)(C)C)CC12CC2>>O=S(=O)(NC[C@@H]1CCCN1Cc1ccccc1)N1CCN(c2ncnc3[nH]ccc23)CC12CC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US04401676,C[Si](C)(C)C#CCN=Cc1ccccc1.ClC1OCOc2c1ccc(-c1ccccc1)c2-c1ccccc1>>C[Si](C)(C)C#CC(N=Cc1ccccc1)C1OCOc2c1ccc(-c1ccccc1)c2-c1ccccc1,,C1CCOC1,O,[Li]CCCC,[Cl-].[NH4+],val
US05506235,CS(=O)(=O)Cl.Cl.Nc1ccc2nc(-c3ccccc3)cc(Nc3ccc(OCC4CCCCC4)cc3)c2c1>>CS(=O)(=O)Nc1ccc2nc(-c3ccccc3)cc(Nc3ccc(OCC4CCCCC4)cc3)c2c1.Cl,,C1CCOC1,,CCN(CC)CC,,val
US04871865,CN(C)CC/C=C1/c2cc(Br)ccc2COc2ccccc21.O=C=O>>CN(C)CC/C=C1/c2cc(C(=O)O)ccc2COc2ccccc21,,CCCCCC,,C1CCOC1,[Li]CCCC,val
US20150148340A1,CCOC(=O)c1cn(-c2ccc3c(c2)[nH]c(=O)n3C)c(=O)[nH]c1=O.FC(F)(F)c1c(Cl)cccc1CBr>>CCOC(=O)c1cn(-c2ccc3c(c2)[nH]c(=O)n3C)c(=O)n(Cc2cccc(Cl)c2C(F)(F)F)c1=O,,CN(C)C=O,O,[I-].[K+],,val
US20030229079A1,Brc1ccc(Cc2ccccc2)s1.CON(C)C(C)=O>>CC(=O)c1ccc(Cc2ccccc2)s1,,CCCCCC,CCOCC,Cl,[Li]CCCC,val
US06891044B2,Nc1ccc(O)cc1.O=Cc1n[nH]c2cc(C(=O)O)ccc12>>NC(=O)c1ccc2c(C=O)n[nH]c2c1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090192162A1,CCOC(=O)COc1ccc(Sc2cc(O)cc(C#CCc3ccccc3)c2)cc1C.OCCCN1CCOCC1>>CCOC(=O)COc1ccc(Sc2cc(C#CCc3ccccc3)cc(OCCCN3CCOCC3)c2)cc1C,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20040053908A1,N#Cc1cc2c(Oc3ccc(N)cc3)ccnc2cc1OCc1ccccc1.O=C=Nc1ccc(F)cc1>>N#Cc1cc2c(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)ccnc2cc1OCc1ccccc1,,CC#N,Cc1ccccc1,,,val
US20130225561A1,COC(=O)Cc1ccc(C#N)c(F)c1>>N#Cc1ccc(CCO)cc1F,,C1CCOC1,,O,[BH4-].[Li+],val
US20040058965A1,COC(=O)Cc1ccc(O)cc1.Cc1oc(-c2ccccc2)nc1COc1ccccc1CCl>>Cc1oc(-c2ccccc2)nc1COc1ccccc1COc1ccc(CC(=O)O)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20120142714A1,CC(C)[Si](Oc1ccc(C(O)Cc2ccc(OCC3CC3)cc2Br)nc1)(C(C)C)C(C)C>>Oc1ccc(C2Cc3ccc(OCC4CC4)cc3O2)nc1,Cl[Cu],Cc1ccccc1,,O,[H-].[Na+],val
US20110144105A1,COCCS(=O)(=O)c1ccc(B(O)O)cc1.Cc1ccc(S(=O)(=O)OC(=CC2CCCC2)c2cc3cccnc3n2S(=O)(=O)c2ccccc2)cc1>>COCCS(=O)(=O)c1ccc(C(=CC2CCCC2)c2cc3cccnc3n2S(=O)(=O)c2ccccc2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20050267095A1,COc1ccc(C2(C#N)CCCCC2)cc1>>N#CC1(c2ccc(O)cc2)CCCCC1,,ClCCl,,BrB(Br)Br,,val
US20120214802A1,CC(C)(C)OC(=O)N1[C@@H](CO)CC[C@H]1c1ccccc1>>CC(C)(C)OC(=O)N1[C@@H](C=O)CC[C@H]1c1ccccc1,,CS(C)=O,,CCN(CC)CC,c1ccncc1,val
US20150291657A1,CCN(CC)S(F)(F)F.CC[C@H](C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O>>CC[C@H](C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)F,,ClCCl,,c1ccncc1,,val
US20030199440A1,COC(=O)[C@@H](C)NS(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1.Cl>>C[C@@H](NS(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1)C(=O)O.Cl,,CO,,[Na+].[OH-],,val
US20040181062A1,Cc1cccc(N)c1N.O=C(O)/C=C/c1ccccc1>>Cc1cccc2[nH]c(/C=C/c3ccccc3)nc12,,O,,[Na+].[OH-],,val
US09439904B2,C=C(OCC)c1nc(Nc2ccc(-n3cnc(C)c3)c(OC)c2)nc(COCC(F)(F)F)c1C>>COc1cc(Nc2nc(COCC(F)(F)F)c(C)c(C(C)=O)n2)ccc1-n1cnc(C)c1,,C1COCCO1,O,Cl,O=C([O-])O.[Na+],val
US05464865,CC1=C(CCCC/C=C(\C)CO)C(C)(C)CCC1.COC(Cc1ccc(O)cc1)OC>>COC(Cc1ccc(OC/C(C)=C/CCCCC2=C(C)CCCC2(C)C)cc1)OC,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030158188A1,CC(C)(N=C=O)c1ccc(Cl)cc1.Nc1cccc2cnccc12>>CC(C)(NC(=O)Nc1cccc2cnccc12)c1ccc(Cl)cc1,,C1CCOC1,,,,val
US20110060156A1,CC(=O)C(=O)Cl.O=C(O)c1ccc(Cl)cc1O>>CC(=O)C(=O)Oc1cc(Cl)ccc1C(=O)O,,CC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US04305937,C#CCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CC(C)S[C@H]12)c1csc(NC=O)n1>>C#CCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CC(C)S[C@H]12)c1csc(N)n1,,CO,,Cl,,val
US20110245205A1,Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3(C(=O)NNC=O)CC3)s2)c1>>Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3(c4nnco4)CC3)s2)c1,,C1CCOC1,,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US20130196968A1,CC(C)(C)OC(=O)N1CC(=O)C1.CNCc1ccccc1>>CN(Cc1ccccc1)C1CN(C(=O)OC(C)(C)C)C1,,CC(=O)O,ClCCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US08309721B2,N#Cc1ccc(-n2c3ccccc3c3c(-c4nc5ccc(F)cc5[nH]4)cccc32)cc1F.NCCOCCO.OO>>NC(=O)c1ccc(-n2c3ccccc3c3c(-c4nc5ccc(F)cc5[nH]4)cccc32)cc1NCCOCCO,,CCO,CS(C)=O,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20100197924A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(N)c1cc(C(=O)O)cc(C(F)(F)F)c1>>CC(C)(C)OC(=O)NC(C)(C)c1cc(C(=O)O)cc(C(F)(F)F)c1,,C1COCCO1,,[Na+].[OH-],,val
US04607034,COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC.S=C=Nc1ccccc1>>COc1cc2nc(N3CCN(C(=S)Nc4ccccc4)CC3)nc(N)c2cc1OC,,C1COCCO1,,,,val
US20070225290A1,CCC(=O)Cl.Oc1cccc(Cl)c1Cl>>CCC(=O)Oc1cccc(Cl)c1Cl,,ClCCl,c1ccncc1,Cl,,val
US20030013715A1,NC1C2CC3CC(C2)CC1C3.O=C(O)c1cnc2ccccc2n1>>O=C(NC1C2CC3CC(C2)CC1C3)c1cnc2ccccc2n1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20110172266A1,COC(=O)CC1=NN(c2ccccc2Cl)C(=O)/C1=C(\C)NCc1ccccn1>>Cc1c2c(=O)n(-c3ccccc3Cl)[nH]c2cc(=O)n1Cc1ccccn1,,CC(C)O,,Cl,[Na],val
US20020037885A1,Brc1ccccc1C1=NOC2(N3CCCC3)CCCCC12>>Brc1ccccc1-c1noc2c1CCCC2,,CO,,Cl,[K+].[OH-],val
US20140336198A1,Brc1ccc(OCc2ccccc2)cc1.CON(C)C(=O)C1CN(C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N1CC(C(=O)c2ccc(OCc3ccccc3)cc2)C1,,C1CCOC1,,[Li]CCCC,,val
US20100093728A1,N#Cc1c(N)nc(S)c(C#N)c1-c1ccc(NCCO)nc1.NC(=S)Nc1ccc(F)cc1.O=C(CCl)CCl>>N#Cc1c(N)nc(SCc2csc(Nc3ccc(F)cc3)n2)c(C#N)c1-c1ccc(NCCO)nc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20090298815A1,CC(C)(C)c1nc(-c2ccc(F)c(NS(=O)(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Cl)n2)s1.CS(=O)(=O)NC1CCC(N)CC1>>CC(C)(C)c1nc(-c2ccc(F)c(NS(=O)(=O)c3c(F)cccc3F)c2)c(-c2ccnc(N[C@@H]3CC[C@@H](NS(C)(=O)=O)CC3)n2)s1,,CCCCO,,,,val
US04904675,CO.N#Cc1ccc(C(=O)O)cn1>>COC(=N)c1ccc(C(=O)O)cn1,,O,,Cl,[Na],val
US20140031336A1,COC(=O)c1ccc(-c2ccc3c(c2)[C@H](N)C[C@H](C)N3C(C)=O)cn1>>CC(=O)N1c2ccc(-c3ccc(C(=O)O)nc3)cc2[C@H](N)C[C@@H]1C,,CO,O,[Li+].[OH-],,val
US20120077828A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cccc(CC(=O)N2CCc3cc(Br)ccc32)c1>>Cc1cccc(CC(=O)N2CCc3cc(B4OC(C)(C)C(C)(C)O4)ccc32)c1,,CCOC(C)=O,,C1COCCO1,CC(=O)[O-].[K+],val
US20100056478A1,CC(C)(C)OC(=O)NCCN.O=C(Nc1ccc(NC(=O)ON2C(=O)CCC2=O)cc1)OCC1c2ccccc2-c2ccccc21>>CC(C)(C)OC(=O)NCCNC(=O)Nc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)cc1,,CC#N,O,O=C([O-])O.[Na+],,val
US05166390,CCCCCCCCn1sccc1=O.O=C(Cl)Cc1ccccc1>>CCCCCCCCNC(=O)/C=C\SC(=O)Cc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04614732,Cl.NCC1=Cc2cccc3cccc1c23>>Cl.NCC1Cc2cccc3cccc1c23,[Pd],CO,,[H][H],,val
US20070265272A1,CC(=O)c1ccc2ncccc2c1.NO>>CC(=NO)c1ccc2ncccc2c1,,CCO,,Cl,[Na+].[OH-],val
US20140221343A1,C#CCCCN.O=[N+]([O-])c1c(Cl)ccnc1Cl>>C#CCCCNc1ccnc(Cl)c1[N+](=O)[O-],,CN(C)C=O,,CCN(CC)CC,,val
US20090118336A1,CC(=O)Nc1cc(-c2cncc(N)c2)n(C)n1.CS(=O)(=O)Cl>>CC(=O)Nc1cc(-c2cncc(NS(C)(=O)=O)c2)n(C)n1,,C1CCOC1,CCN(CC)CC,C1CCNC1,,val
US04086423,COC(NC(=O)Cc1cccs1)C(=O)[O-]>>COC(NC(=O)Cc1cccs1)C(=O)O,,CO,,[K+].[OH-],,val
US20160115128A1,CO.OCC1CCN(c2nc(Cl)ncc2Br)CC1>>COc1ncc(Br)c(N2CCC(CO)CC2)n1,,C1CCOC1,CO,O,C[O-].[Na+],val
US20080214549A1,CC(C)c1nn(Cc2ccc(Br)cc2)c(=O)c(C(=O)NCC(=O)O)c1O.COc1cc(B(O)O)ccn1>>COc1cc(-c2ccc(Cn3nc(C(C)C)c(O)c(C(=O)NCC(=O)O)c3=O)cc2)ccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20020086892A1,CCCc1cc(-c2ccccc2)ccc1O.CCOC(=O)Cl>>CCCc1cc(-c2ccccc2)ccc1OC(=O)OCC,,CCOC(C)=O,,CCN(CC)CC,,val
US20030166638A1,Cc1ccccc1.O=C(O)c1ccc(Cl)c([N+](=O)[O-])c1>>CCOC(=O)c1ccc(Cl)c([N+](=O)[O-])c1,,O=S(Cl)Cl,,,,val
US20080004289A1,C[C@@H]1CNCCN1.FC(F)(F)c1cccc(C(Cl)C2CC2)c1>>C[C@@H]1CNCCN1C(c1cccc(C(F)(F)F)c1)C1CC1,,CC#N,,,,val
US20040147543A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCN.O=[N+]([O-])c1cnc2cc(Br)ccc2c1Cl>>CC(C)(C)OC(=O)NCCNc1c([N+](=O)[O-])cnc2cc(Br)ccc12,,ClC(Cl)Cl,O,CCN(CC)CC,,val
US20130116247A1,CCOC(=O)CBr.COc1ccc2nc(S)[nH]c2c1>>CCOC(=O)CSc1nc2ccc(OC)cc2[nH]1,,CN(C)C=O,,[H-].[Na+],,val
US20120157458A1,O=C(O)c1ccoc1.O=C1CCC(=O)N1O>>O=C(ON1C(=O)CCC1=O)c1ccoc1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04232032,NC(=O)c1ccc2c(c1)C(C(Cl)(Cl)Cl)OC(C(Cl)(Cl)Cl)O2>>NC(=O)c1ccc2c(c1)C(=C(Cl)Cl)OC(=C(Cl)Cl)O2,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20110098324A1,CC(C)CN.CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(Cc2ccccc2Br)c1=O>>CC(C)CNC(=O)c1c(O)c(C(=O)NCC(=O)O)c(=O)n(Cc2ccccc2Br)c1O,,ClC(Cl)Cl,,Cl,,val
US20120094832A1,CCOC(=O)Cl.CCc1cc(C)cc(CC)c1C1C(=O)C2C3CCC(O3)C2C1=O>>CCOC(=O)OC1=C(c2c(CC)cc(C)cc2CC)C(=O)C2C3CCC(O3)C12,,ClCCl,,CCN(CC)CC,,val
US20040248875A1,CCOP(=O)(CC#N)OCC.Nc1c(C=O)cnn1CCOC(c1ccccc1)(c1ccccc1)c1ccccc1>>N#C/C=C/c1cnn(CCOC(c2ccccc2)(c2ccccc2)c2ccccc2)c1N,,C1CCOC1,,[H-].[Na+],,val
US05589474,N#Cc1cc([N+](=O)[O-])ccc1F.Nc1ccccc1S>>N#Cc1cc([N+](=O)[O-])ccc1Sc1ccccc1N,,CN(C)C=O,,[H-].[Na+],,val
US05859014,CS(=O)(=O)Cl.Cc1cn(Cc2ccccc2)c(=O)n(CC2(CO)CC2)c1=O>>Cc1cn(Cc2ccccc2)c(=O)n(CC2(COS(C)(=O)=O)CC2)c1=O,,O,,CCN(CC)CC,ClCCl,val
US20130281433A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(Br)sc2c1-c1ccc(Cl)cc1.Cc1cn(-c2cccc(B3OC(C)(C)C(C)(C)O3)c2)c(=O)[nH]c1=O>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3cccc(-n4cc(C)c(=O)[nH]c4=O)c3)sc2c1-c1ccc(Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100210674A1,O=C1Cc2ccc(Cl)cc2N1.O=Cc1ccc(Cl)o1>>O=C1Nc2cc(Cl)ccc2/C1=C/c1ccc(Cl)o1,,CO,,C1CCNCC1,,val
US20140024636A1,CCOC(=O)CN.O=S(=O)(Cl)Cl>>CCOC(=O)CNS(=O)(=O)Cl,,CC#N,,Cl,,val
US20020055497A1,CC(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2CC2CO2)C1.c1ccc2[nH]c(C3CCNCC3)nc2c1>>CC(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2CC(O)CN2CCC(c3nc4ccccc4[nH]3)CC2)C1,,CCO,,,,val
US20110301167A1,Cc1ccccc1-n1nc2c3ccccc3n(Cc3ccc(Br)nc3)nc-2c1=O.c1c[nH]cn1>>Cc1ccccc1-n1nc2c3ccccc3n(Cc3ccc(-n4ccnc4)nc3)nc-2c1=O,[Cu]I,CS(C)=O,O,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20120035196A1,CCOC(=O)CBr.COCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)-c3ccccc3C4=O)c2C)c(C)c1>>CCOC(=O)C=C1c2ccccc2-c2cc(OCc3cccc(-c4c(C)cc(OCOC)cc4C)c3C)ccc21,[Zn],C1CCOC1,,Cl,,val
US05723608,CCCBr.CCCNc1nc(C)nc2c(-c3c(C)cc(C)cc3C)n(C)nc12>>CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)n(C)nc12,,CS(C)=O,,[K+].[OH-],,val
US20100286110A1,COC(=O)c1ccc(-c2ccc(OC3CN(C(=O)OC(C)(C)C)C3)cn2)cc1F>>CC(C)(C)OC(=O)N1CC(Oc2ccc(-c3ccc(C(=O)O)c(F)c3)nc2)C1,,CO,O,[Li+].[OH-],,val
US08148523B2,NC(=O)c1cccn1N.O=C(N=C=S)c1ccccc1>>NC(=O)c1cccn1NC(=S)NC(=O)c1ccccc1,,CC(C)=O,,,,val
US20090137561A1,Cc1cc(CO)ccc1Br.O=S(Cl)Cl>>Cc1cc(CCl)ccc1Br,,ClCCl,,,,val
US20150197511A1,Cc1cc([N+](=O)[O-])cnc1Oc1ccnc(NC(=O)C2CC2)c1>>Cc1cc(N)cnc1Oc1ccnc(NC(=O)C2CC2)c1,,CO,ClCCl,,,val
US20090111789A1,CC(C)(C)OC(=O)N1CCC(N2CCNC(=O)C2)CC1.Cl>>Cl.O=C1CN(C2CCNCC2)CCN1,,CO,,,,val
US20060074056A1,Nc1ccc(Oc2ncnc3cc(-c4ccccc4)[nH]c23)c(F)c1.O=C(Cc1ccccc1)N=C=S>>O=C(Cc1ccccc1)NC(=S)Nc1ccc(Oc2ncnc3cc(-c4ccccc4)[nH]c23)c(F)c1,,C1CCOC1,,,,val
US20090239810A1,COc1ccccc1S(C)(=O)=O>>CS(=O)(=O)c1ccccc1O,,ClCCl,O,BrB(Br)Br,,val
US20050272778A1,O=C1C=C(c2ccc(COCc3ccc(Oc4ccccc4)cc3)cc2)S(=O)(=O)N1>>O=C1CC(c2ccc(COCc3ccc(Oc4ccccc4)cc3)cc2)S(=O)(=O)N1,,C1CCOC1,,[BH4-].[Li+],,val
US20110212918A1,COc1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(OC)c1>>O=S(=O)(Nc1ccc2c(c1)B(O)OC2)c1ccc(O)cc1O,,ClCCl,,BrB(Br)Br,O,val
US20160024110A1,BrBr.COc1ccc(F)cc1F>>COc1cc(Br)c(F)cc1F,,O=S(=O)(O)O,,,,val
US20120225844A1,CI.O=C1c2cc(COc3ccccc3)nn2C[C@@H](CO)N1c1ccc(F)cc1>>COC[C@@H]1Cn2nc(COc3ccccc3)cc2C(=O)N1c1ccc(F)cc1,,C1CCOC1,,[H-].[Na+],,val
US20160264562A1,CCOC(=O)[C@@H](C)OC(=O)C1=C(CBr)NC(c2nccs2)=N[C@H]1c1ccc(Cl)cc1Cl.O=C(O)[C@@H]1COCCN1>>CCOC(=O)[C@@H](C)OC(=O)C1=C(CN2CCOC[C@H]2C(=O)O)NC(c2nccs2)=N[C@H]1c1ccc(Cl)cc1Cl,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20060292079A1,Cc1cc(C(=O)NCCN(CCNC(=O)c2cc(C)[nH]c(=O)c2OCc2ccccc2)CC(CCCC(=O)O)NC(=O)c2ccc(C(=O)O)c(OCc3ccccc3)c2OCc2ccccc2)c(OCc2ccccc2)c(=O)[nH]1>>Cc1cc(C(=O)NCCN(CCNC(=O)c2cc(C)[nH]c(=O)c2O)CC(CCCC(=O)O)NC(=O)c2ccc(C(=O)O)c(O)c2O)c(O)c(=O)[nH]1,,CC(=O)O,,Cl,,val
US20140274954A1,C=CCc1ccc(C(=O)O)c(C)c1O.CC(=O)OC(C)=O>>C=CCc1ccc(C(=O)O)c(C)c1OC(C)=O,,O,,Cl,[Na+].[OH-],val
US20100069367A1,CC(C)(C(=N)Nc1ccc(Br)cc1)c1ccccc1Cl.CC(C)(C)OC(=O)N1CCCC1C(=O)CI>>CC(C)(C)OC(=O)N1CCCC1c1cn(-c2ccc(Br)cc2)c(C(C)(C)c2ccccc2Cl)n1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20160115158A1,COC(=O)c1cccc(S(=O)(=O)Nc2nnc(Cl)cc2O)c1>>O=C(O)c1cccc(S(=O)(=O)Nc2nnc(Cl)cc2O)c1,,CCO,,[Na+].[OH-],,val
US04410528,COc1cc(C(=O)C(C)N2CCC(N3Cc4ccccc4NC3=NC#N)CC2)cc(OC)c1OC>>COc1cc(C(O)C(C)N2CCC(N3Cc4ccccc4NC3=NC#N)CC2)cc(OC)c1OC,,CCO,,[BH4-].[Na+],,val
US20140148464A1,CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,,C1CCOC1,CO,,,val
US20130274260A1,COc1ccc(B(O)O)cc1.O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1cccc(CCl)c1>>COc1ccc(Cc2cccc(C(=O)NCCc3c[nH]c4ccc(Cl)cc34)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,[I-].[Na+],,val
US20030092712A1,COc1cc(Br)c(C)c(Br)c1.O=C1CCC(=O)N1Br>>COc1cc(Br)c(CBr)c(Br)c1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20040254214A1,CCOc1cc([C@H](N)CS(C)(=O)=O)ccc1OC.COC(=O)c1c(NC(=O)C2CC2)ccc(F)c1CBr>>CCOc1cc([C@@H](CS(C)(=O)=O)N2Cc3c(F)ccc(NC(=O)C4CC4)c3C2=O)ccc1OC,,CN(C)C=O,,CCN(CC)CC,,val
US20070149585A1,CS(=O)(=O)Cl.O=C1NCc2ccc3c(c21)C=CCO3>>CS(=O)(=O)N1Cc2ccc3c(c2C1=O)C=CCO3,,C1CCOC1,,[H-].[Na+],,val
US04087522,COP(=O)(CC(=O)O)OC.NC1CCCCC1>>O=C(CP(=O)(O)O)NC1CCCCC1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20160159774A1,CC(C)(C)N1Cc2ccc([N+](=O)[O-])cc2C1>>CC(C)(C)N1Cc2ccc(N)cc2C1,[Pd],CO,,,,val
US20150105317A1,CC(=O)OC[C@H]1OC(OCCCl)[C@H](F)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>OC[C@H]1OC(OCCCl)[C@H](F)[C@@H](O)[C@@H]1O,,CO,,CO[Na],,val
US20020042430A1,N#CCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1>>NCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1,[Ni],C1CCOC1,,[H][H],,val
US20050239841A1,COc1ccc([C@@]23CCC(N)C[C@@H]2N(C)CC3)cc1OC(F)(F)F.O=C=Nc1cc(F)cc(C(F)(F)F)c1>>COc1ccc([C@@]23CC[C@@H](NC(=O)Nc4cc(F)cc(C(F)(F)F)c4)C[C@@H]2N(C)CC3)cc1OC(F)(F)F,,ClCCl,,,,val
US20090197871A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)O)c1.NCc1cc(Cl)cc(Br)c1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2cc(Cl)cc(Br)c2)c1,,ClCCl,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20090221687A1,CCOC(=O)c1cc2c(s1)-c1cc(Cl)cc(OC)c1Oc1ccccc1-2>>CCOC(=O)c1cc2c(s1)-c1cc(Cl)cc(O)c1Oc1ccccc1-2,,ClCCl,O,BrB(Br)Br,,val
US20030144507A1,CCO.O=S(=O)(Nc1ccc2c(Cl)nccc2c1)c1ccc(Cl)cc1>>CCOc1nccc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc12,,CS(C)=O,,O,[H-].[Na+],val
US20070244159A1,CC1(C#Cc2cc([N+](=O)[O-])ccc2N)CC1.CCCC(=O)Cl>>CCCC(=O)Nc1ccc([N+](=O)[O-])cc1C#CC1(C)CC1,,ClCCl,,c1ccncc1,,val
US20110065766A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C(NC12CC3CC(C1)C(=O)C(C3)C2)OCc1ccccc1>>O=C(NC12CC3CC(C1)C(=S)C(C3)C2)OCc1ccccc1,,Cc1ccccc1,,,,val
US20140201855A1,CC1=CC(C)(C)N(C(=O)C(F)(F)F)c2ccc(NC(=O)OC(C)(C)C)cc21>>CC1=CC(C)(C)N(C(=O)C(F)(F)F)c2ccc(N)cc21,,ClCCl,,Cc1ccccc1,O=C(O)C(F)(F)F,val
US20080249318A1,CCc1ccc(N)cc1.O=C(Cl)CCl>>CCc1ccc(NC(=O)CCl)cc1,,Cc1ccccc1,,C1CCOC1,O=C([O-])O.[Na+],val
US20120094958A1,CCOC(=O)c1ccc2cc(I)cc(-c3cccc4ccccc34)c2n1.OB(O)c1ccsc1>>CCOC(=O)c1ccc2cc(-c3ccsc3)cc(-c3cccc4ccccc34)c2n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],val
US20100298320A1,O=[N+]([O-])c1cc(C(F)(F)F)ccc1F.Oc1cccnc1>>O=[N+]([O-])c1cc(C(F)(F)F)ccc1Oc1cccnc1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20040009998A1,CCOC(=O)CNC.O=C=Nc1cc(Cl)nc(Cl)c1>>CN1CC(=O)N(c2cc(Cl)nc(Cl)c2)C1=O,,ClCCl,,Cl,,val
US20120065214A1,COC(=O)c1ccc(C)c(-n2ccnc(N[C@@H](c3ccccc3)[C@@H](C)CO)c2=O)c1.NC1CC1>>Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(N[C@@H](c2ccccc2)[C@@H](C)CO)c1=O,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20110003738A1,Cc1ccc(COc2ccnc(Cl)c2)cn1.O=CO>>Cc1ccc(COc2cc[nH]c(=O)c2)cn1,,O,O=CO,C,O=C[O-].[NH4+],val
US20160237067A1,Cc1ccc(-c2ccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CNC(=O)OC(C)(C)C)CC3)C(=O)Nc3ccc(-c4nn[nH]n4)cc3)cc2)cc1NC(=O)C1CCOCC1.Cl>>Cc1ccc(-c2ccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CN)CC3)C(=O)Nc3ccc(-c4nn[nH]n4)cc3)cc2)cc1NC(=O)C1CCOCC1.Cl,,C1COCCO1,,,,val
US20100234351A1,CC(C)(C)OC(=O)NO.COCCBr>>COCCONC(=O)OC(C)(C)C,,CN(C)C=O,,O,[H-].[Na+],val
US05039331,C1=COCCC1.Oc1cc(N=C=S)c(F)cc1Cl>>Fc1cc(Cl)c(OC2CCCCO2)cc1N=C=S,,ClCCl,,,,val
US20100240638A1,C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)NS(=O)(=O)c1ccccc1NCCCCCCC[C@H](NC(=O)OC1CCCC1)C(=O)OC>>C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)c1ccccc1NCCCCCCC[C@H](NC(=O)OC1CCCC1)C(=O)OC,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120142671A1,CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1cc(Nc2cc(-c3ccccc3)no2)c(C#N)cc1F>>N#Cc1cc(F)c(N[C@@H]2CCCC[C@@H]2N)cc1Nc1cc(-c2ccccc2)no1,,O=C(O)C(F)(F)F,,,,val
US20120129811A1,CCN.O=[N+]([O-])c1cccc([N+](=O)[O-])c1Cl>>CCNc1c([N+](=O)[O-])cccc1[N+](=O)[O-],,CCO,,,,val
US20080255105A1,CCOC(=O)c1ccc(-c2cc([N+](=O)[O-])ccc2OC)cc1.Cl>>CCOC(=O)c1ccc(-c2cc(N)ccc2OC)cc1.Cl,,CCO,,,,val
US20150329529A1,CI.Cc1cc(=O)n(C2CCCCC2)[nH]1>>Cc1cc(=O)n(C2CCCCC2)n1C,,CN(C)C=O,ClCCl,O,O=C([O-])[O-].[K+].[K+],val
US20080280875A1,CCOC(=O)CCC(=O)OCC.O=Cc1cccs1>>CCOC(=O)C(=Cc1cccs1)CC(=O)O,,CCO,,C,C[O-].[Na+],val
US20040058903A1,CC(=O)c1ccc(-c2ccccc2C(=O)Nc2ccc(NCCc3ccccn3)cc2)cc1>>CC(O)c1ccc(-c2ccccc2C(=O)Nc2ccc(NCCc3ccccn3)cc2)cc1,,CO,,[BH4-].[Na+],,val
US20030125370A1,Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)O.NCCN1CCC(F)CC1>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)NCCN1CCC(F)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US03952101,C=O.Cc1ncccc1O>>Cc1nc(CO)ccc1O,,CC(=O)O,,O,[Na+].[OH-],val
US20160159752A1,CC(C)[Mg]Br.O=C(/C=C/c1ccc(Cl)cc1)N1C(=O)OC[C@@H]1c1ccccc1>>CC(C)[C@@H](CC(=O)N1C(=O)OC[C@@H]1c1ccccc1)c1ccc(Cl)cc1,,C1CCOC1,,CSC,,val
US04363865,O=C1c2ccccc2C(=O)N1CCl.O=[N+]([O-])c1ccc(O)cc1>>O=C1c2ccccc2C(=O)N1COc1ccc([N+](=O)[O-])cc1,,CC(=O)O,CN(C)C=O,[H-].[Na+],,val
US20080176864A1,Cc1c(N2CCCC2CC(=O)NNC(=O)OC(C)(C)C)ccc(C#N)c1Cl>>Cc1c(N2CCCC2CC(=O)NN)ccc(C#N)c1Cl,,O=C(O)C(F)(F)F,,,,val
US20080119488A1,CC(=O)c1ccc(B(O)O)s1.CCOc1cc(Cl)nc(SC)n1>>CCOc1cc(-c2ccc(C(C)=O)s2)nc(SC)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20030186969A1,C#CCBr.O=C1CN(C(=O)c2ccc(Cl)cc2)Cc2ccccc2N1>>C#CCN1C(=O)CN(C(=O)c2ccc(Cl)cc2)Cc2ccccc21,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20100004288A1,CNC1CCCc2ccccc21.Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C(=O)Cl)cs2)CC1>>Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C(=O)N(C)C3CCCc4ccccc43)cs2)CC1,,ClCCl,,CCN(CC)CC,,val
US20100261743A1,CC(C)(C)OC(=O)N1Cc2ccc(C(=O)NCc3ccccc3C(F)(F)F)cc2C1>>O=C(NCc1ccccc1C(F)(F)F)c1ccc2c(c1)CNC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US07964560B2,C=CCS[C@@]1(c2ccc(-c3ccccc3)cc2)C[C@@H](C(=O)O)N(C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)C1.C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)C1CC1.Cc1ccc(S(=O)(=O)O)cc1>>C=CCS[C@@]1(c2ccc(-c3ccccc3)cc2)C[C@@H](C(=O)N[C@]2(C(=O)NS(=O)(=O)C3CC3)C[C@H]2C=C)N(C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)C1.O,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04810713,CC(=O)c1ccc(O)c(C)c1.ClCCCBr>>CC(=O)c1ccc(OCCCCl)c(C)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050107377A1,Fc1ccc2c(-c3ccc(OC[C@H]4CO4)cc3)noc2c1.c1ccc(N2CCNCC2)cc1>>O[C@@H](COc1ccc(-c2noc3cc(F)ccc23)cc1)CN1CCN(c2ccccc2)CC1,,CCO,CN(C)C=O,,,val
US05120843,C=CCc1cc(C)c(O)c(C)c1.CI>>CC=Cc1cc(C)c(OC)c(C)c1,,CS(C)=O,,[K+].[OH-],,val
US06022906,BrC(Br)(Br)Br.CCC(Cc1ccccc1)(C(=O)c1ccc(OCCCO)c(OC)c1)N(C)C>>CCC(Cc1ccccc1)(C(=O)c1ccc(OCCCBr)c(OC)c1)N(C)C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05866576,C=CCCCCCCCCCBr.Cn1c(=O)c2[nH]cnc2n(C)c1=O>>C=CCCCCCCCCCn1cnc2c1c(=O)n(C)c(=O)n2C,,CS(C)=O,,O,[H-].[Na+],val
US20070270433A1,FC(F)(F)c1cccc(CN2CCNCC2)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(Cl)N1CCN(Cc2cccc(C(F)(F)F)c2)CC1,,C1CCOC1,,c1ccncc1,,val
US20100152177A1,CC(C)(C)OC(=O)N1CCN(c2c[nH]c3ccccc23)CC1.O=C1COc2cc(S(=O)(=O)Cl)ccc2N1>>O=C1COc2cc(S(=O)(=O)n3cc(N4CCNCC4)c4ccccc43)ccc2N1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20140350043A1,CC(N)(Cc1c[nH]c2ccccc12)C(=O)O>>CC(N)(CO)Cc1c[nH]c2ccccc12,,C1CCOC1,,,,val
US20030069273A1,COc1ccc(NN)cc1.O=c1nc(-c2ccccc2O)oc2ccccc12>>COc1ccc(-n2nc(-c3ccccc3O)nc2-c2ccccc2O)cc1,,CCO,,CCN(CC)CC,Cl,val
US20070191603A1,CCOC(=O)c1ccc(NC(=O)c2ccc3c(c2)N(S(=O)(=O)c2cc(Cl)ccc2OC)CCO3)cc1>>COc1ccc(Cl)cc1S(=O)(=O)N1CCOc2ccc(C(=O)Nc3ccc(C(=O)O)cc3)cc21,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20150258074A1,COC(=O)[C@@H](N)c1ccccc1.COc1ccc(C=O)cc1>>COC(=O)[C@@H](NCc1ccc(OC)cc1)c1ccccc1,,CO,,CC(=O)O,[BH4-].[Na+],val
US20080234306A1,BrCc1ccccc1.CCO[C@@]12CCC(=O)[C@@H]3Oc4c(O)ccc5c4[C@@]31CC[N+]([O-])(CC1CC1)[C@@H]2C5>>C=C1CC[C@@]2(O)[C@H]3Cc4ccc(OCc5ccccc5)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5,,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],,val
US20010021777A1,CN=C=O.Clc1ccc2c(C3=CCN(CCC4CNc5ccccc54)CC3)c[nH]c2c1.O=C([O-])C(=O)[O-]>>CNC(=O)N1CC(CCN2CC=C(c3c[nH]c4cc(Cl)ccc34)CC2)c2ccccc21.O=C(O)C(=O)O,,ClCCl,,,,val
US20120225863A1,Cc1cc2cc(-c3nc4ccc(C(=O)NC(C)(C)C)cc4nc3N(C)C(C)C)ccc2[nH]1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1[nH]c2ccc(-c3nc4ccc(C#N)cc4nc3N(C)C(C)C)cc2c1C(=O)C(F)(F)F,,ClCCl,O,O=C([O-])O.[Na+],,val
US20060004046A1,CCOC(=O)c1cnc2ccc(I)cc2c1Cl.CO>>COC(=O)c1cnc2ccc(I)cc2c1OC,,CO,,C[O-].[Na+],,val
US06432993B1,Cc1c(O)ccc(Oc2ccc([N+](=O)[O-])c(N(C)C(=O)OC(C)(C)C)c2)c1C>>Cc1c(O)ccc(Oc2ccc(N)c(N(C)C(=O)OC(C)(C)C)c2)c1C,[Pd],CO,,,,val
US20110020278A1,COC(=O)c1sc(C#CC(C)(C)C)cc1N.O=C1CC(OCc2ccccc2)C1>>COC(=O)c1sc(C#CC(C)(C)C)cc1NC1CC(OCc2ccccc2)C1,,CCOC(C)=O,ClCCl,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120010228A1,ClCCCBr.Cn1c(=O)[nH]c2ccccc21>>Cn1c(=O)n(CCCCl)c2ccccc21,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20150080588A1,CC(=O)SCC[C@]1(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C=C[C@@H](NC(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N[C@@H]1C=C[C@](CCS)(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1,,CO,,[Na+].[OH-],,val
US20110123493A1,COc1ccc(B2OC(C)(C)C(C)(C)O2)cc1S(C)(=O)=O.NS(=O)(=O)c1ccc(CNc2nc(NC3(C(F)(F)F)CC3)c3nc(Cl)ccc3n2)cc1>>COc1ccc(-c2ccc3nc(NCc4ccc(S(N)(=O)=O)cc4)nc(NC4(C(F)(F)F)CC4)c3n2)cc1S(C)(=O)=O,,COCCOC,,O=C([O-])O.[Na+],,val
US20030166644A1,CN(C(=O)Cl)c1ccccc1.O=[N+]([O-])c1cnc(O)c(C(F)(F)F)c1>>CN(C(=O)Oc1ncc([N+](=O)[O-])cc1C(F)(F)F)c1ccccc1,,C1CCOC1,,C1CN2CCN1CC2,,val
US20150225404A1,CO.Fc1ncccc1-c1cc(OCc2ccccn2)nc2c1CCCC2>>COc1ncccc1-c1cc(OCc2ccccn2)nc2c1CCCC2,,CO,,CC(C)(C)O[K],,val
US04727180,O=C(O)CCc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1.O=[N+]([O-])O>>O=C(O)CCc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1[N+](=O)[O-],,O=S(=O)(O)O,,O,,val
US20040001889A1,CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C>>CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C,,O,,Cl,[Na+].[OH-],val
US20100152155A1,CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.O=C(O)c1ccc(N2CC3C(C2)C3NCc2ccc3ccccc3c2)cc1.On1nnc2ccccc21>>CC(C)COC(C)ONC(=O)c1ccc(N2CC3C(C2)C3NCc2ccc3ccccc3c2)cc1,,O,,Cl,,val
US05536716,CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CN(C(=O)OCc1ccccc1)c1ccc(F)cc12>>CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CNc1ccc(F)cc12,CCN(CC)CC,CCO,,[H][H],,val
US20110034437A1,C1CCN(C2=NOCC2)C1.CI>>C[N+]1(C2=NOCC2)CCCC1.[I-],,CO,,,,val
US20040087511A1,CC(C)(C)OC(=O)OC(C)(C)C.CC[C@@H](C)[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)NCc1ccc(C(=N)N)cc1>>CC[C@@H](C)[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)NCc1ccc(/C(N)=N\C(=O)OC(C)(C)C)cc1,,CN(C)C=O,,CCN(CC)CC,CCOC(C)=O,val
US20130048975A1,CCn1c2ccccc2c2cc3c4ccc(OS(=O)(=O)C(F)(F)F)cc4c4ccccc4c3cc21.OB(O)c1ccccc1>>CCn1c2ccccc2c2cc3c4ccc(-c5ccccc5)cc4c4ccccc4c3cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20140128425A1,CCCC[C@@H](NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12)C(=O)OC.Cl>>CCCC[C@H](NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12)C(=O)O.Cl,,C1CCOC1,CO,[Li+].[OH-],,val
US20010018430A1,COc1cc(S(=O)(=O)Cl)cc(OC)c1OC.COc1ccc(N)cc1O>>COc1ccc(NS(=O)(=O)c2cc(OC)c(OC)c(OC)c2)cc1O,,CO,,,,val
US20070179151A1,COc1cc2c(OC(C)C)nc(Nc3cc(C)[nH]n3)cc2cc1OCc1ccccc1>>COc1cc2c(OC(C)C)nc(Nc3cc(C)[nH]n3)cc2cc1O,[Pd],CO,,[H][H],,val
US20160207922A1,Cc1c([C@@H]2CO2)ccc2c1COC2=O.N#Cc1ccc(N2CC3(CCNCC3)CC2=O)nc1>>Cc1c([C@@H](O)CN2CCC3(CC2)CC(=O)N(c2ccc(C#N)cn2)C3)ccc2c1COC2=O,,CCO,,,,val
US20100029619A1,CC(C)(C)c1ccc(C#N)cn1.CCOC(C)=O.O>>CC(C)(C)c1ccc(C(=O)O)cn1,,CCOC(C)=O,Cl,[Na+].[OH-],,val
US20050277611A1,CC1(C)OC[C@@H](COCc2ccccc2)O1>>OC[C@H](O)COCc1ccccc1,,CO,,Cl,O=C([O-])O.[Na+],val
US20110021537A1,CC(C)(C)OC(=O)N1CCC(NC(=O)OCc2ccccc2)C1>>O=C(NC1CCNC1)OCc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120101136A1,C[Si](C)(C)CCOCOc1ccc(C#N)cc1.NO>>C[Si](C)(C)CCOCOc1ccc(C(=N)NO)cc1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20140094462A1,CC(=O)N[C@@H]1CC=CCCC(=O)N[C@H](c2ccccc2)COC1=O.CI>>CC(=O)N(C)[C@@H]1CC=CCCC(=O)N[C@H](c2ccccc2)COC1=O,,CN(C)C=O,,[H-].[Na+],,val
US20080076924A1,CS(=O)(=O)c1ccc(C(=O)CBr)cc1.NCCN>>CS(=O)(=O)c1ccc(C2CNCCN2)cc1,,CCO,,[BH4-].[Na+],,val
US20060154926A1,CCCC(=O)N1C(=O)OC[C@H]1Cc1ccccc1.CCCOCc1cc(CBr)cc2ccccc12>>CCCOCc1cc(C[C@H](CC)C(=O)N2C(=O)OC[C@H]2Cc2ccccc2)cc2ccccc12,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20080009530A1,CCOC(=O)/C=C/c1ccc(OCCOC)cc1Oc1ncc(NC(=O)OC(C)(C)C)cc1C>>COCCOc1ccc(/C=C/C(=O)O)c(Oc2ncc(NC(=O)OC(C)(C)C)cc2C)c1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20080182852A1,CCOC(=O)c1ccc(Nc2ncc(F)c(Nc3ccccc3C(=O)NC(C)C)n2)cc1>>CC(C)NC(=O)c1ccccc1Nc1nc(Nc2ccc(CO)cc2)ncc1F,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040157844A1,COc1ccc(Oc2c(C)cc(-n3ncc(=O)[nH]c3=O)cc2Cl)cc1S(=O)(=O)c1ccccc1>>Cc1cc(-n2ncc(=O)[nH]c2=O)cc(Cl)c1Oc1ccc(O)c(S(=O)(=O)c2ccccc2)c1,,ClCCl,,ClB(Cl)Cl,,val
US20150252033A1,C=CCC[C@@H]1CO1.ONCc1ccccc1>>C=CCC[C@@H](O)CN(O)Cc1ccccc1,,CO,,CCN(CC)CC,Cl,val
US20140057920A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1ccc2sccc2c1>>CC(C)(C)OC(=O)NCc1ccc2sccc2c1,,ClCCl,,CCN(CC)CC,O,val
US20140378540A1,CC(C)(C)[Si](C)(C)OCCBr.CO[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(O)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CO[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(OCCO[Si](C)(C)C(C)(C)C)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100298336A1,Cc1cc(O)nc(SCc2csc(C)n2)n1.Cl>>Cc1cc(O)nc(SCc2csc(C)n2)n1.Cl,,CO,,C1COCCO1,,val
US08288565B2,C[C@H](N[C@H]1CCCC[C@@H]1CO)c1ccccc1>>N[C@H]1CCCC[C@@H]1CO,[Pd],CO,,,,val
US20160152543A1,COC(=O)C(O)c1c(C)ccc(C2CC2)c1-c1ccc2c(c1)CCCO2.CS(=O)(=O)OS(C)(=O)=O>>COC(=O)C(OS(C)(=O)=O)c1c(C)ccc(C2CC2)c1-c1ccc2c(c1)CCCO2,,ClCCl,,CCN(CC)CC,O,val
US20050065066A1,COc1ccc(C=O)c2oc(C(=O)O)cc12>>COc1ccc(C=O)c2occc12,,c1ccc2ncccc2c1,,Cl,O,val
US20040267015A1,CO.COC(=O)Cc1cc(Cl)c(O)c(Cl)c1>>COC(=O)Cc1cc(Cl)c(OC)c(Cl)c1,,CO,ClCCl,C[Si](C)(C)C=[N+]=[N-],,val
US20150225452A1,COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C.COC(=O)c1ccc(CBr)cc1>>COC(=O)c1ccc(COc2ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)OC)cc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04021438,CCOC=S.[C-]#[N+]CC(=O)OCC>>CCOC(=O)c1cscn1,,CCO,,[C-]#N.[Na+],,val
US05880115,CCCCCCCNC(=O)C1=CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C.NS(=O)(=O)Cl>>CCCCCCCNC(=O)C1=CC[C@H]2[C@@H]3CCc4cc(OS(N)(=O)=O)ccc4[C@H]3CC[C@]12C,,CN(C)C=O,,[H-].[Na+],,val
US20080076776A1,Nc1nc(I)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O.OB(O)c1cc(F)c(F)c(F)c1>>Nc1nc(-c2cc(F)c(F)c(F)c2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030229079A1,BrCc1ccccc1.O=Cc1ncc[nH]1>>O=Cc1nccn1Cc1ccccc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20020169203A1,CCC(C#N)c1ccccc1Cl.CCI>>CCC(C#N)(CC)c1ccccc1Cl,,CN(C)C=O,,[H-].[Na+],,val
US20100197908A1,C#Cc1ccc(OCCO)cc1.Ic1ccc(Oc2ccccc2)nn1>>OCCOc1ccc(C#Cc2ccc(Oc3ccccc3)nn2)cc1,I[Cu]I,C1CCOC1,,CC(C)NC(C)C,,val
US05298655,CC(C)=CCC/C(C)=C/CC/C(C)=C/CBr.[N-]=[N+]=[N-]>>CC(C)=CCC/C(C)=C/CC/C(C)=C/CN=[N+]=[N-],,CN(C)C=O,,O,,val
US20070219205A1,CC1(C)OB(c2cnc3[nH]ccc3c2)OC1(C)C.COC(=O)c1sc(Br)cc1OC(C)c1ccccc1Cl>>COC(=O)c1sc(-c2cnc3[nH]ccc3c2)cc1OC(C)c1ccccc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US20050267093A1,COc1cc([N+](=O)[O-])ccc1OCCN1CCc2ccccc2C1>>COc1cc(N)ccc1OCCN1CCc2ccccc2C1,,CO,ClCCl,,,val
US20160052884A1,COc1cn(C(CCF)C(=O)OC(C)(C)C)c(=O)cc1-c1cc(Cl)ccc1C#N>>COc1cn(C(CCF)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N,,ClCCl,,O=C(O)C(F)(F)F,,val
US04780541,C=O.CO.Cc1ccc(O)c(N=Nc2ccccc2[N+](=O)[O-])c1.O=C1c2ccccc2-c2ccccc21.c1ccc(N=Nc2ccccc2)cc1>>CC(C)(C)CC(C)(C)c1ccc(O)c(N=Nc2ccccc2[N+](=O)[O-])c1,,CO,O,[Na+].[OH-],,val
US20160060267A1,CC(C)c1c(-c2cnn(COCC[Si](C)(C)C)c2F)[nH]c2c(C#N)cnn2c1=O>>CC(C)c1c(-c2cn[nH]c2F)[nH]c2c(C#N)cnn2c1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120101085A1,COc1ccccc1C.O=C(OO)c1cccc(Cl)c1>>COc1ccc(O)cc1C,,CN(C)C=O,O,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US04659718,CCCCO.Cn1nnnc1-c1cn(C)c2cc(F)ccc2c1=O>>CCCCOc1ccc2c(=O)c(-c3nnnn3C)cn(C)c2c1,,CCCCO,,O,[Na],val
US04018790,O=C(Cl)C(=O)Cl.O=C(O)c1ccc([N+](=O)[O-])c([N+](=O)[O-])c1>>O=C(Cl)c1ccc([N+](=O)[O-])c([N+](=O)[O-])c1,,c1ccncc1,,c1ccccc1,,val
US20110301175A1,CS(=O)(=O)Cl.OCCc1ccc(Nc2ncc(Br)cn2)cc1>>CS(=O)(=O)OCCc1ccc(Nc2ncc(Br)cn2)cc1,,ClCCl,O,CCN(CC)CC,,val
US20110245205A1,COC(=O)[C@H]1CC[C@](O)(c2ncc(-c3cc(CN)cc(Nc4nccc(C(F)(F)F)n4)c3)s2)CC1(C)C>>CC1(C)C[C@@](O)(c2ncc(-c3cc(CN)cc(Nc4nccc(C(F)(F)F)n4)c3)s2)CC[C@@H]1C(=O)O,,CO,,[Na+].[OH-],,val
US20060052382A1,CC(C)C(CC(C)(C)C)Nc1c(C2CC2)nc2cnccn12>>Nc1c(C2CC2)nc2cnccn12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100120798A1,Cc1ccc(NC(=O)C2(CN)CCN(C(=O)OC(C)(C)C)CC2)nc1.N=C(c1ccccc1)c1ccccc1>>Cc1ccc(NC(=O)C2(CN=C(c3ccccc3)c3ccccc3)CCN(C(=O)OC(C)(C)C)CC2)nc1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080214533A1,CC(C)(C)[Si](C)(C)OCCNc1ccc(NC(=O)c2[nH]cnc2C(=O)O)cc1.Nc1ccc(Cl)cc1>>CC(C)(C)[Si](C)(C)OCCNc1ccc(NC(=O)c2[nH]cnc2C(=O)Nc2ccc(Cl)cc2)cc1,,C1CCOC1,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110201604A1,CCn1c(Nc2nc3ccc(C(F)(F)F)cc3s2)nc2cc(C(=O)O)ccc21.COC(C)(C)CN>>CCn1c(Nc2nc3ccc(C(F)(F)F)cc3s2)nc2cc(C(=O)NCC(C)(C)OC)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140235667A1,Fc1ccc2nc(Cl)cn2c1.O=C1CCC(=O)N1I>>Fc1ccc2nc(Cl)c(I)n2c1,,CC#N,,,,val
US04920116,CCNCC.[N-]=[N+]=NCC(=O)c1cccc2ccccc12>>CCN(CC)C(CN=[N+]=[N-])c1cccc2ccccc12,,CO,,Cl,[BH3-]C#N.[Na+],val
US20120101127A1,Cc1ccc2c(c1)C(C)(C)CC(c1cccc(N)c1)N2.O=S(=O)(Cl)c1cccc(F)c1>>Cc1ccc2c(c1)C(C)(C)CC(c1cccc(NS(=O)(=O)c3cccc(F)c3)c1)N2,,ClCCl,,c1ccncc1,,val
US03950353,CN=C=S.Cc1cn(C)c(CSCCN)n1>>CNC(=S)NCCSCc1nc(C)cn1C,,CCO,,CCOC(C)=O,,val
US20140343000A1,C=C(C)[C@@H]1CC[C@]2(NCCN3CCNCC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CN(C)C(=O)C(=O)O>>C=C(C)[C@@H]1CC[C@]2(NCCN3CCN(C(=O)C(=O)N(C)C)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US05068334,CC1CC2=C(CCCC2=O)NC1=O.CI>>CC1CC2=C(CCCC2=O)N(C)C1=O,,CC(C)=O,,,,val
US20040082611A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)CC1CN(S(=O)(=O)c2cc3cc(Cl)ccc3n2S(=O)(=O)c2ccccc2)CCN1>>COC(=O)CC1CN(S(=O)(=O)c2cc3cc(Cl)ccc3n2S(=O)(=O)c2ccccc2)CCN1C(=O)OC(C)(C)C,,CCO,,,,val
US04202978,COC(=O)Cc1ccc(O)cc1.c1ccc(COC[C@@H]2CO2)cc1>>COC(=O)Cc1ccc(OC[C@@H](O)COCc2ccccc2)cc1,,CO,,Cl,[Na],val
US20080114006A1,CC(=O)OC(C)=O.CC(C)(C)c1cc(NC(=O)OCC(Cl)(Cl)Cl)n(-c2cccc([N+](=O)[O-])c2)n1>>CC(=O)Nc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)c1,[Pd],CCOC(C)=O,,,,val
US20100168418A1,COc1ccc2ncc(=O)n(CCN3CCC(N)CC3)c2c1.O=Cc1cnc2c(c1)OCCO2>>COc1ccc2ncc(=O)n(CCN3CCC(NCc4cnc5c(c4)OCCO5)CC3)c2c1,,CC(=O)O,ClC(Cl)Cl,O=C([O-])O.[Na+],,val
US05707989,CN.Cc1cccc(Nc2ncnc3cnc(N4CCC(C(=O)O)CC4)nc23)c1>>CNC(=O)C1CCN(c2ncc3ncnc(Nc4cccc(C)c4)c3n2)CC1,,CCN(CC)CC,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20140378446A1,BrCCBr.Nc1cc([N+](=O)[O-])ccc1O>>O=[N+]([O-])c1ccc2c(c1)NCCO2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04666510,COC(Cl)Cl.Cc1cc(O)cc(C)c1Cl>>Cc1cc(O)c(C=O)c(C)c1Cl,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US05256362,Cl.NCCCl.SC1=NCCS1>>Cl.Cl.NCCSC1=NCCS1,,c1ccccc1,,,,val
US20050026821A1,CC(C)(C)C1NC(=O)C(CN(C=O)OCc2ccccc2)CCCC=CCCCCNC1=O>>CC(C)(C)C1NC(=O)C(CN(O)C=O)CCCCCCCCCNC1=O,[Pd],CCOC(C)=O,,CO,[H][H],val
US20070287725A1,CCOCc1nc2c(Cl)nc3ccccc3c2n1CCCc1cc(-c2cccnc2)no1.N>>CCOCc1nc2c(N)nc3ccccc3c2n1CCCc1cc(-c2cccnc2)no1,,CO,,,,val
US06420410B1,CCOC(=O)Cc1cccc2[nH]c(=O)n(Cc3ccccc3)c12>>O=C(O)Cc1cccc2[nH]c(=O)n(Cc3ccccc3)c12,,CCO,,[K+].[OH-],,val
US04839379,CN.Nc1ccc(C2(C(=O)O)CC2C(=O)O)cc1>>CN1C(=O)C2CC2(c2ccc(N)cc2)C1=O,,CO,,,,val
US20130029962A1,C=Cc1ccc([N+](=O)[O-])cn1.CS(=O)[O-]>>CS(=O)(=O)CCc1ccc([N+](=O)[O-])cn1,,CCO,,CC(=O)O,,val
US20040235841A1,CCOC(=O)c1cccc(N)c1.N#CN.O=[N+]([O-])O>>CCOC(=O)c1cccc(NC(=N)N)c1.O=NO,,CCO,,,,val
US20050245512A1,CC(O)c1nccs1.O=C(O)CBr>>CC(O)C1SC=CN1CC(=O)O,,O,,,,val
US20140142105A1,CCOC(C)=O.N#Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1ccccc1NS(=O)(=O)c1ccc(C#N)cc1,,O,c1ccncc1,,,val
US20040127477A1,BrCCBr.CC(C)(C)OC(=O)CBr.[Zn]>>CC(C)(C)OC(=O)C[Zn]Br,,C1CCOC1,,,,val
US20040009526A1,O=C1CSC(=S)N1.O=Cc1ccc(-c2ccc(C(=O)O)cc2)o1>>O=C1NC(=S)SC1=Cc1ccc(-c2ccc(C(=O)O)cc2)o1,,CCO,,C1CCNCC1,,val
US20120184565A1,CNCCNc1nc(Cl)nc2c1CCC2c1ccc(F)cc1.N#Cc1ccc([N+](=O)[O-])cc1OCCBr>>CN(CCNc1nc(Cl)nc2c1CCC2c1ccc(F)cc1)CCOc1cc([N+](=O)[O-])ccc1C#N,,CN(C)C=O,,,,val
US20090023710A1,N#Cc1ccccc1Oc1ccc(Cl)cc1>>NCc1ccccc1Oc1ccc(Cl)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150133368A1,CC(C)(C)OC(=O)NCCCOS(C)(=O)=O.[N-]=[N+]=[N-]>>CC(C)(C)OC(=O)NCCCN=[N+]=[N-],,CN(C)C=O,,O,,val
US20100317698A1,CC(C)(C)OC(=O)NCC1(COc2cnc(Cl)c(-c3ccc(N)cc3)c2)CC1.S=C(Cl)Cl>>CC(C)(C)OC(=O)NCC1(COc2cnc(Cl)c(-c3ccc(N=C=S)cc3)c2)CC1,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US05935990,CC(=O)c1ccc(F)cc1.O=Cc1ccco1>>O=C(CCc1ccco1)c1ccc(F)cc1,,CO,,C[O-].[Na+],,val
US04650800,O=C(CBr)c1cc2c(s1)CCCC2.O=c1ncc(Cl)c[nH]1>>O=C(Cn1cc(Cl)cnc1=O)c1cc2c(s1)CCCC2,,CCO,,CCN(CC)CC,,val
US20070099990A1,CC(=O)Oc1cc(C)cc2c1CCC2>>Cc1cc(O)c2c(c1)CCC2,,CCCCCC,CCOC(C)=O,,,val
US20160016966A1,Cn1cc(-c2ccncc2N)c2oc(CN3CCN(S(C)(=O)=O)CC3)cc2c1=O.O=CC1CC1>>Cn1cc(-c2ccncc2NCC2CC2)c2oc(CN3CCN(S(C)(=O)=O)CC3)cc2c1=O,,CC(=O)O,CO,,,val
US20120004240A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(NN)nccc4cc3-c3ccccc3)cc2)CCC1.O=C(n1ccnc1)n1ccnc1>>NC1(c2ccc(-c3nc4c(ccn5c(=O)[nH]nc45)cc3-c3ccccc3)cc2)CCC1,,C1COCCO1,CCOC(C)=O,,,val
US20140228349A1,C=CC1(n2cc(B3OC(C)(C)C(C)(C)O3)cn2)CN(C(=O)OC(C)(C)C)C1.Cn1cc(-c2cc3nccn3c(Cl)n2)cn1>>C=CC1(n2cc(-c3nc(-c4cnn(C)c4)cc4nccn34)cn2)CN(C(=O)OC(C)(C)C)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20140187553A1,Cc1ccc(S(=O)(=O)n2cc(I)c3cc(-c4n[nH]c(=O)o4)ccc32)cc1.NC1CC1>>Cc1ccc(S(=O)(=O)n2cc(I)c3cc(-c4nnc(NC5CC5)o4)ccc32)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20020028797A1,NCC1CC1.O=S(=O)(Cl)c1ccc(F)cc1>>O=S(=O)(NCC1CC1)c1ccc(F)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160096827A1,C=O.COc1cc(Nc2ncnc(-c3ccc(O[C@H]4CCN(C(=O)[C@H](C)O)C[C@H]4F)c(C#N)c3)n2)ccc1N1CCNC[C@@H]1C>>COc1cc(Nc2ncnc(-c3ccc(O[C@H]4CCN(C(=O)[C@H](C)O)C[C@H]4F)c(C#N)c3)n2)ccc1N1CCN(C)C[C@@H]1C,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20130225554A1,CC1(C)C[C@H]1C(=O)NNC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OCc1ccccc1>>CC1(C)C[C@@H]1C(=O)NNC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2O,[Pd],CO,,,,val
US20160016951A1,Cn1cc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)cn1.O=C(O)c1ccc2cncc(Br)c2n1>>Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)O)nc34)cc2)cn1,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20130274241A1,CN1CC=C(B(O)O)CC1.O=C(c1ccc(-n2cc(-c3n[nH]c4ccc(Br)cc34)nn2)cc1)N1CCOCC1>>CN1CC=C(c2ccc3[nH]nc(-c4cn(-c5ccc(C(=O)N6CCOCC6)cc5)nn4)c3c2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,O,[Cs+].[F-],,val
US20140275044A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(NC1=NC2(c3cc(Br)ccc3F)CNCC2CS1)c1ccccc1>>CC(C)(C)OC(=O)N1CC2CSC(NC(=O)c3ccccc3)=NC2(c2cc(Br)ccc2F)C1,,ClCCl,,CCN(CC)CC,,val
US20040192729A1,C1CNCCN1.COC(=O)c1cnc(Cl)s1>>COC(=O)c1cnc(N2CCNCC2)s1,,CCO,,O=C([O-])O.[Na+],,val
US05608101,CO.O=C(c1ccc(Cl)cc1[N+](=O)[O-])C1C(=O)C2CCC(C2)C1=O>>COC1C2CCC(C2)C(=O)C1C(=O)c1ccc(Cl)cc1[N+](=O)[O-],O=S(=O)(O)O,,,,,val
US04935522,CCOC(=O)C(C)Oc1ccc(OC(C)=O)cc1>>CCOC(=O)C(C)Oc1ccc(O)cc1,Cl,CCO,,,,val
US20120108709A1,CC#N.CCON1C(C)(C)CC(=O)CC1(C)C>>CCON1C(C)(C)CC(O)(CC#N)CC1(C)C,,C1CCOC1,,[Li]CCCC,,val
US20160002224A1,COC(=O)CCC(=O)c1cc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc2n1COCC[Si](C)(C)C>>C[Si](C)(C)CCOCn1c(C(=O)CCC(=O)O)cc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc21,,CO,O,Cl,[Li]O,val
US20100120790A1,CC(C)(C)OC[C@@H]1C(=O)NCCN1C(=O)C[C@@H](Cc1cc(F)c(F)cc1F)NC(=O)OC(C)(C)C.Cl>>CC(C)(C)OC[C@@H]1C(=O)NCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F.Cl,,CO,,CCOCC,,val
US20060258714A1,[N-]=[N+]=NC[C@H]1CCCc2cc(F)cc(-c3c(Cl)cccc3Cl)c2O1>>NC[C@H]1CCc2cc(F)cc(-c3c(Cl)cccc3Cl)c2O1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150094474A1,CC1(C)C(/C=C(\Cl)C(F)(F)F)C1C(=O)/C=C/c1cccc(Oc2ccccc2)c1.C[Si](C)(C)C#N>>CC1(C)C(/C=C(\Cl)C(F)(F)F)C1C(=O)CC(C#N)c1cccc(Oc2ccccc2)c1,,C1COCCO1,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20130102527A1,CC(C)(C)OC(=O)NCc1ccc(C[C@H](NC(=O)OCc2ccccc2)C(=O)[C@@]2(C)CO2)cc1.O=C(O)C(F)(F)F>>CC(C)(C)OC(=O)NCc1ccc(C[C@H](N)C(=O)[C@@]2(C)CO2)cc1.O=C(O)C(F)(F)F,,CO,,,,val
US20030225113A1,C1CSCCN1.CC(C)(C)NC(=O)c1sc2nc(-c3ccccc3)nc(-c3cccc(NC(=O)Oc4ccc([N+](=O)[O-])cc4)c3)c2c1N>>CC(C)(C)NC(=O)c1sc2nc(-c3ccccc3)nc(-c3cccc(NC(=O)N4CCSCC4)c3)c2c1N,,ClCCl,ClCCl,,,val
US20030225057A1,COc1ccc2c(c1)CCN(C(=O)C(F)(F)F)CC2C.ClI>>COc1cc2c(cc1I)C(C)CN(C(=O)C(F)(F)F)CC2,,CO,,O=C([O-])[O-].[Ca+2],,val
US20100216991A1,COc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1.O=C(OC[C@H]1OC(Cl)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1)c1ccccc1>>COc1nc(N)c2ncn([C@@H]3O[C@H](COC(=O)c4ccccc4)[C@@H](OC(=O)c4ccccc4)[C@H]3OC(=O)c3ccccc3)c2n1,,Cc1ccccc1C,,,,val
US20110118266A1,C1CNCCN1.Cn1nc(Br)c(=O)n(C)c1=O>>Cn1nc(N2CCNCC2)c(=O)n(C)c1=O,,Cc1ccccc1,,CCN(CC)CC,ClCCl,val
US20120277229A1,CN1CCC(C)(C(=O)Nc2ccc3c(c2)c(-c2nc4ccccc4[nH]2)nn3C2CCCCO2)CC1>>CN1CCC(C)(C(=O)Nc2ccc3[nH]nc(-c4nc5ccccc5[nH]4)c3c2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100168094A1,N#Cc1cc(C2CCCC2)c(O)cc1[N+](=O)[O-]>>N#Cc1cc(C2CCCC2)c(O)cc1N,[Pd],CCO,,,,val
US20150119362A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1nc(-c2cccc(Cl)c2)nc2c1SCCC2>>O=S(=O)(Oc1nc(-c2cccc(Cl)c2)nc2c1SCCC2)C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20140315022A1,C=CCNCC=C.O=C1CCC(=O)O1>>C=CCN(CC=C)C(=O)CCC(=O)O,,ClCCl,,,,val
US06121283,O=C(Nc1ccc2c(c1)CCNC2)c1ccccc1-c1ccc(C(F)(F)F)cc1.O=CCc1ccccc1>>O=C(Nc1ccc2c(c1)CCN(CCc1ccccc1)C2)c1ccccc1-c1ccc(C(F)(F)F)cc1,,ClCCCl,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130018034A1,C[C@H](N)C(F)(F)F.O=C(O)c1cnc(Cl)cn1>>C[C@H](NC(=O)c1cnc(Cl)cn1)C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20100035841A1,Cl.O=P1(CC2CC2)CCN(Cc2ccccc2)CC1>>Cl.O=[PH]1CCN(CC2CC2)CC1,,CCO,,,,val
US07553969B1,CC(C)(C)OC(=O)N[C@@H](Cc1cccc(F)c1)C(=O)O.CN[C@H](C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)C(C)C>>CC(C)[C@@H](C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@H](Cc1cccc(F)c1)NC(=O)OC(C)(C)C,,C1CCOC1,,O,,val
US05314918,CCCc1c(O)ccc2c(=O)cc(C(=O)OCC)oc12.CN(C)NC(=S)Cl>>CCCc1c(OC(=S)N(C)C)ccc2c(=O)cc(C(=O)OCC)oc12,,ClCCl,,CN(C)C=O,[H-].[Na+],val
US20070197604A1,NC(CCOCc1ccccc1)C(=O)O.O=C(Cl)c1ccc(Br)cc1F>>O=C(NC(CCOCc1ccccc1)C(=O)O)c1ccc(Br)cc1F,,CC(C)=O,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US06194410B1,CCOC(=O)N=C(C)OCC.CSc1n[nH]c(N)c1S(=O)(=O)c1ccccc1>>CSc1nn2c(=O)[nH]c(C)nc2c1S(=O)(=O)c1ccccc1,,CC(=O)O,,,,val
US05043341,CC(=O)Cl.N[C@@H]1CCC[C@H]1O>>CC(=O)N[C@@H]1CCC[C@H]1O,,C1CCOC1,,CCN(CC)CC,,val
US20100056516A1,Nc1cccc(-c2ccc3c(c2)CN(c2cc(=O)n(OCc4ccccc4)c4ncccc24)CC3)c1>>Nc1cccc(-c2ccc3c(c2)CN(c2cc(=O)n(O)c4ncccc24)CC3)c1,,CCO,,,,val
US20100029611A1,CC(=O)c1ccccc1F.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>C=C(OS(=O)(=O)C(F)(F)F)c1ccccc1F,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US20120040957A1,CC(C)(C)OC(=O)NC1CCNCC1.ClCC1CS1>>CC(C)(C)OC(=O)NC1CCN(CC2CS2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04292317,CCn1cc(C(=O)O)c(=O)c2cc(Cl)c(Cl)cc21.c1ccc(N2CCNCC2)cc1>>CCn1cc(C(=O)O)c(=O)c2cc(Cl)c(N3CCN(c4ccccc4)CC3)cc21,,CC(=O)O,,c1ccncc1,,val
US20040077669A1,CC#CCO.CN(c1ccccc1)c1cc(Cl)ncn1>>CC#CCOc1cc(N(C)c2ccccc2)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20090054427A1,CC(C)(C)c1cccc(C=O)c1.CCCCc1cc(C[C@@H]2CS(=O)(=O)C[C@H](N)[C@H]2O)cc(F)c1NC(=O)OCc1ccccc1>>CCCCc1cc(C[C@@H]2CS(=O)(=O)C[C@H](NCc3cccc(C(C)(C)C)c3)[C@H]2O)cc(F)c1NC(=O)OCc1ccccc1,,CCCCCC,CCOC(C)=O,Cl,,val
US08138168B1,CC(C)(C)OC(=O)N[C@@H](CC(=O)O)Cc1ccc2ccccc2c1.COCCCn1c([C@@H]2CCCNC2)nc2cccc(Cl)c21>>COCCCn1c([C@@H]2CCCN(C(=O)C[C@@H](Cc3ccc4ccccc4c3)NC(=O)OC(C)(C)C)C2)nc2ccccc21,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160221945A1,COC(=O)[C@@H]1CC(F)(CF)CN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CC(F)(CF)C[C@H]1C(=O)O,,C1CCOC1,O,[Li+].[OH-],,val
US20090143371A1,CN.Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1>>CNC(=O)c1ccc(OCc2c(-c3ccccc3)noc2C)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20070299085A1,Cc1cc(Cn2cc(I)c(C(F)(F)F)n2)ccc1[N+](=O)[O-].FC(F)(F)C(F)(F)C(F)(F)C(F)(F)I>>Cc1cc(Cn2cc(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c(C(F)(F)F)n2)ccc1[N+](=O)[O-],[Cu],Cc1ccccc1,,CN(C)C=O,,val
US20160185778A1,C[C@@H]1CC(=O)C(C(=O)C2CCCC2)CN1C(=O)OC(C)(C)C.NN>>C[C@@H]1Cc2[nH]nc(C3CCCC3)c2CN1C(=O)OC(C)(C)C,,CCO,,O,,val
US20080085890A1,CC(C)(C)c1ccc(C(=O)O)c(CC(=O)O)c1.NC(N)=O>>CC(C)(C)c1ccc2c(c1)CC(=O)NC2=O,,ClC(Cl)Cl,,,,val
US20130158003A1,O=Cc1nc(-c2ccccc2)cn1C(c1ccccc1)(c1ccccc1)c1ccccc1>>O=Cc1nc(-c2ccccc2)c[nH]1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100160384A1,Cc1ccc(-c2cc(C)n(CCO[Si](C)(C)C(C)(C)C)n2)cc1NC(=O)C1=CNC(=O)C[C@H]1c1ccc(F)cc1>>Cc1ccc(-c2cc(C)n(CCO)n2)cc1NC(=O)C1=CNC(=O)C[C@H]1c1ccc(F)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04349552,CCCCCC(O)=S.CCN(CC)CC.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCCSCCN=C=O,,c1ccccc1,,,,val
US20100249118A1,OC(c1c(F)ccc(OCCOC2CCCCO2)c1F)c1c[nH]c2ncc(Br)cc12>>OCCOc1ccc(F)c(Cc2c[nH]c3ncc(Br)cc23)c1F,,CC#N,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20130172302A1,CN1CCN(C(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)CC1=O.O=C(CCl)c1ccccc1>>CN1CCN(C(C(=O)O[C@H]2C[N+]3(CC(=O)c4ccccc4)CCC2CC3)c2ccccc2)CC1=O.[Cl-],,CC#N,CCOC(C)=O,,,val
US20020006936A1,COC(=O)C(Cc1ccc(C)c(OC)c1)C(=O)OC>>COc1cc(CCC(=O)O)ccc1C,,CO,O,[Na+].[OH-],,val
US20140005222A1,COC(=O)c1ccc(C)c(NC(=O)c2cc(N3CCCC(CO)C3)ccc2C)c1C>>Cc1ccc(N2CCC(CO)C2)cc1C(=O)Nc1c(C)ccc(C(=O)O)c1C,,CO,,[Na+].[OH-],,val
US06245913B1,COS(=O)(=O)OC.Cc1c[n+]([O-])cc(C)c1[N+](=O)[O-]>>COS(=O)(=O)OC.Cc1c[n+]([O-])cc(C)c1[N+](=O)[O-],,CC(C)=O,,,,val
US05652363,COc1c[n+]([O-])ccc1[N+](=O)[O-]>>COc1cnccc1N,[Ni],CO,,,,val
US05703098,CCOc1cc(C(CCO)N2C(=O)c3ccccc3C2=O)ccc1OC.CI>>CCOc1cc(C(CCOC)N2C(=O)c3ccccc3C2=O)ccc1OC,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US05208343,CCCI.ON=C(CCc1cccnc1)c1ccccc1>>CCC[n+]1cccc(CCC(=NO)c2ccccc2)c1.[I-],,CC#N,,,,val
US20030013754A1,CCOC(=O)C(CC(=O)c1ccccc1)C(C)=O.Nc1ccc([N+](=O)[O-])cn1>>CCOC(=O)c1cc(-c2ccccc2)n(-c2ccc([N+](=O)[O-])cn2)c1C,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120190700A1,Cc1c[nH]c2ccccc12.O=C1CCC(=O)N1Br>>CC1(Br)C(=O)Nc2ccccc21,,C1CCOC1,CC(C)(C)O,O,,val
US05840732,O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C1CSC(=O)N1CCCCSc1cccc2nccn12>>O=C1CSC(=O)N1CCCCSc1cccc2ncc(C(=O)C(F)(F)F)n12,,ClCCl,,CCN(CC)CC,[Na+].[OH-],val
US20120035053A1,COc1cc(Cl)cc(OC)c1.O=CC1CCOC1>>COc1cc(OC)cc(C(O)C2CCOC2)c1,,C1CCOC1,,II,[Mg],val
US20070066617A1,Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)N(C)CC(=O)O>>Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)NCC(=O)O,,CO,O,Cl,[K+].[OH-],val
US04168976,C=CNc1ccccc1.COc1nc(Cl)nc(Cl)n1>>C=Cc1ccc(Nc2nc(Cl)nc(OC)n2)cc1,,CC(C)=O,,CCN(C(C)C)C(C)C,,val
US20070197478A1,BrCc1ccccc1.CCOC(=O)Nc1cc(Br)nc(Br)c1[N+](=O)[O-]>>CCOC(=O)N(Cc1ccccc1)c1cc(Br)nc(Br)c1[N+](=O)[O-],,CC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20060135578A1,COC(=O)CBr.COc1cc(COc2nn(-c3ccccc3)cc2C=O)ccc1OCc1nc(-c2cccc(O)c2)oc1C>>COC(=O)COc1cccc(-c2nc(COc3ccc(COc4nn(-c5ccccc5)cc4C=O)cc3OC)c(C)o2)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20060235030A1,CNCCN.Cc1ccc(C(=O)NCC2CC2)cc1-c1nc(S(C)=O)nc2c1CNC(=O)N2c1c(F)cccc1F>>Cc1ccc(C(=O)NCC2CC2)cc1-c1nc(N(C)CCN)nc2c1CNC(=O)N2c1c(F)cccc1F,,C1CCOC1,,,,val
US04263291,CCOC(=O)C(=NOC)C(C)=NNC(=O)OC(C)(C)C.O=S(Cl)Cl>>CCOC(=O)C(=NOC)c1csnn1,,CCOC(C)=O,,,,val
US05789440,CCC(C)c1ccccc1S.O=C1OC(c2ccccc2)(c2ccccc2)CC(O)=C1Br>>CCC(C)c1ccccc1SC1=C(O)CC(c2ccccc2)(c2ccccc2)OC1=O,,ClCCl,,C1CCNCC1,,val
US20120184542A1,CC(C)(C)OC(=O)NCC(NC(=O)c1ccc(Cl)c(NC(=O)c2cc3cnc(S(C)(=O)=O)nc3[nH]c2=O)c1)c1ccccc1.CN1CCN(CCN)CC1>>CN1CCN(CCNc2ncc3cc(C(=O)Nc4cc(C(=O)NC(CNC(=O)OC(C)(C)C)c5ccccc5)ccc4Cl)c(=O)[nH]c3n2)CC1,,O,,CN(C)C=O,,val
US04113715,COC(=O)CC(CSC(C)=O)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C>>CC(=O)SCC(CC(=O)O)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C,,CO,O,[Na+].[OH-],,val
US20090275619A1,COC(=O)c1cccc(C=O)c1[N+](=O)[O-].Nc1cccc(C2OCCO2)c1>>COC(=O)c1cccc(/C=N/c2cccc(C3OCCO3)c2)c1[N+](=O)[O-],,CCOC(C)=O,,,,val
US05220018,CI.O=[N+]([O-])c1cccc(-c2nnn[nH]2)c1>>Cn1nnc(-c2cccc([N+](=O)[O-])c2)n1,,C1CCOC1,,[H-].[Na+],,val
US20160207930A1,CCc1cc(CO)nc(C(F)(F)F)c1>>CCc1cc(C=O)nc(C(F)(F)F)c1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20020173664A1,CCCCCCCCCC(=O)Cl.C[C@@H]1NC(=O)OC1=O>>CCCCCCCCCC(=O)N1C(=O)OC(=O)[C@@H]1C,,CCOC(C)=O,,CN1CCOCC1,,val
US20070078156A1,CC(C)(CO)NC(=O)c1c(F)cccc1F>>CC1(C)COC(c2c(F)cccc2F)=N1,,ClCCl,,O=S(Cl)Cl,,val
US20060111406A1,NCCc1ccc(Oc2ccccc2)cc1.O=C(Br)CBr>>O=C(CBr)NCCc1ccc(Oc2ccccc2)cc1,,ClCCl,,c1ccncc1,,val
US20110166121A1,CC(=O)OC(C)=O.CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(-n3ccc(N)n3)nc2s1>>CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(-n3ccc(NC(C)=O)n3)nc2s1,,CCCCCC,ClCCl,CCN(CC)CC,CCOC(C)=O,val
US20080255133A1,CO.O=C(O)c1cnc(Cl)c(Cl)c1Nc1ccc(Br)cc1Cl>>COC(=O)c1cnc(Cl)c(Cl)c1Nc1ccc(Br)cc1Cl,,Cc1ccccc1,,C[Si](C)(C)C=[N+]=[N-],,val
US20130217664A1,CCc1cc(-c2cn[nH]c2)ccc1N(C)c1cc2c(cn1)ncn2C.NC(=O)CBr>>CCc1cc(-c2cnn(CC(N)=O)c2)ccc1N(C)c1cc2c(cn1)ncn2C,,CN(C)C=O,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20130029962A1,CC(C)(C)c1cc(CN)n(-c2cccc(Cl)c2)n1.O=C(Nc1ccc(NCCO)nc1)Oc1ccccc1>>CC(C)(C)c1cc(CNC(=O)Nc2ccc(NCCO)nc2)n(-c2cccc(Cl)c2)n1,,CC#N,,CCN(CC)CC,,val
US04515948,COC(=O)c1cc(OC)c(NC(C)=O)c(OC)c1.CS(C)(=O)=O>>COc1cc(C(=O)CS(C)(=O)=O)cc(OC)c1NC(C)=O,,O,,CS(C)=O,[H-].[Na+],val
US20090221555A1,CN1CCNC(=O)c2cccc([N+](=O)[O-])c21>>CN1CCNC(=O)c2cccc(N)c21,[Pd],CO,,,,val
US06657052B1,CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cc(C(O)CN)cc(C)c1OCc1ccccc1[N+](=O)[O-].Cl>>Cc1cc(C(O)C[NH+]=C(N)N)cc(C)c1OCc1ccccc1[N+](=O)[O-].Cl,,CCOCC,,,,val
US05013863,NCCCP(=O)(O)c1ccccc1>>NCCCP(=O)(O)C1CCCCC1,,Cl,O,[H][H],,val
US20140221333A1,CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccncc1.COC(=O)[C@H](CO)NCc1ccccc1.ClCCl>>COC(=O)[C@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)NCc1ccccc1,CN(C)c1ccncc1,ClCCl,,O,,val
US20140018319A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)O[C@@H]1CN(c2cc(C#N)cc(N)c2Cl)CC[C@H]1N>>CC(C)(C)OC(=O)N[C@@H]1CCN(c2cc(C#N)cc(N)c2Cl)C[C@H]1O[Si](C)(C)C(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US05350762,Cn1c2c(c3cc(OCc4ccccc4)ccc31)CC(C(=O)O)C2.N>>Cn1c2c(c3cc(OCc4ccccc4)ccc31)CC(C(N)=O)C2,,CCO,,,,val
US20100331326A1,CCN1C(=O)CCc2cc(Br)ccc21.O=C1NCCN1c1cccnc1>>CCN1C(=O)CCc2cc(N3CCN(c4cccnc4)C3=O)ccc21,I[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=C([O-])[O-].[K+].[K+],val
US04783461,N#CCc1n[nH]c(=O)c2ccccc12.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>N#CCc1nnc(S)c2ccccc12,,c1ccncc1,,,,val
US20040092737A1,COCN1c2cc(CC(=N)SC)ccc2Sc2nccnc21.Nc1ccccc1>>COCN1c2cc(CC(=N)Nc3ccccc3)ccc2Sc2nccnc21,,C1CCOC1,CO,,,val
US20150209443A1,CC(C)n1nccc1-c1ncccc1O.O=Cc1ccccc1CBr>>CC(C)n1nccc1-c1ncccc1OCc1ccccc1C=O,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US05043482,COc1ccc(O)c2c1C(C)(C)CCC2(C)C.O=C(Cl)c1ccccc1>>COc1cc(Cc2ccccc2)c(O)c2c1C(C)(C)CCC2(C)C,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20060004084A1,ClCCN1CCOCC1.O=C1OCc2cc(O)ccc21>>O=C1OCc2cc(OCCN3CCOCC3)ccc21,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100168144A1,COc1ccccc1B(O)O.Clc1cc(Cl)ncn1>>COc1ccccc1-c1ccnc(Cl)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,ClCCl,O=C([O-])O.[Na+],val
US20090215779A1,NNC(=O)C(=O)Nc1ccc(N2CCOCC2)c(F)c1.O=C(N=C=S)c1ccc(Cl)cc1>>O=C(Nc1nnc(C(=O)Nc2ccc(N3CCOCC3)c(F)c2)o1)c1ccc(Cl)cc1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20130079324A1,CN(C)CCn1cc(Nc2nc(Oc3cccc(NC(=O)OC(C)(C)C)c3)c3ccn(COCC[Si](C)(C)C)c3n2)cn1>>CN(C)CCn1cc(Nc2nc(Oc3cccc(N)c3)c3ccn(CO)c3n2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04205073,Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F.OO>>Cc1c(Nc2ncc(O)cc2C(=O)O)cccc1C(F)(F)F,,O,,CC(=O)O,,val
US20090012093A1,Brc1ccc(C2OCCO2)cc1.Cc1cccc(C)c1C=O>>Cc1cccc(C)c1C(O)c1ccc(C2OCCO2)cc1,II,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US20100099680A1,COC(=O)c1cc([N+](=O)[O-])cc(S(C)(=O)=O)c1>>COC(=O)c1cc(N)cc(S(C)(=O)=O)c1,[Pd],CO,,,,val
US04526894,COC(=O)c1cccc2[nH]c(=O)c(C(=O)c3ccccc3)c(O)c12>>O=C(c1ccccc1)c1c(O)c2c(C(=O)O)cccc2[nH]c1=O,,CS(C)=O,,O,[Na+].[OH-],val
US20110065691A1,CCc1nn(C2CCC2)c2cc(N3CCN(c4cccc([N+](=O)[O-])n4)C(Cc4ccccc4)C3)ccc12>>CCc1nn(C2CCC2)c2cc(N3CCN(c4cccc(N)n4)[C@@H](Cc4ccccc4)C3)ccc12,,C1CCOC1,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20060116364A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(N)COc1ccc(C#N)cc1>>CC(C)(COc1ccc(C#N)cc1)NC(=O)OC(C)(C)C,,CCN(CC)CC,ClCCl,O,,val
US20120245144A1,Cc1ccnc(-c2cn3c(n2)-c2cc(SC4CCN(C(C)C)CC4)ccc2OCC3)c1.O=C(OO)c1cccc(Cl)c1>>Cc1ccnc(-c2cn3c(n2)-c2cc(S(=O)C4CCN(C(C)C)CC4)ccc2OCC3)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)O)cc1.Nc1ccc2[nH]c(=O)oc2c1>>Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3[nH]c(=O)oc3c2)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090227588A1,NCc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cc1.O=C(Cl)c1cccnc1>>O=C(NCc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cc1)c1cccnc1,,CCOC(C)=O,ClCCl,CCN(CC)CC,Cl,val
US04350637,CC(C)C[C@H](N)C(=O)OCc1ccccc1.O=C1OC(O)C2C3C=CC(C3)C12>>CC(C)C[C@H](N[C@H]1OC(=O)[C@@H]2[C@@H]3C=C[C@@H](C3)[C@H]12)C(=O)OCc1ccccc1,,c1ccccc1,,,,val
US20060258740A1,CC(C)N(NC(=O)c1ccccc1)C(=O)CCc1ccccc1Br.Cc1ccccc1B(O)O>>Cc1ccccc1-c1ccccc1CCC(=O)N(NC(=O)c1ccccc1)C(C)C,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20090253681A1,CC(C)(NCCCO)c1nc(O)c(O)c(C(=O)NCc2ccc(F)cc2)n1>>CC1(C)NCCCn2c1nc(C(=O)NCc1ccc(F)cc1)c(O)c2=O,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060069077A1,CN1CCN(CC#N)CC1.NO>>CN1CCN(CC(=N)NO)CC1,,CCO,,,,val
US20150344427A1,CCN(c1cc(Cl)cc(C(=O)NCc2c(OCc3ccc(OC)cc3)cc(C)nc2NC)c1C)[C@@H]1CC[C@@H](N(C)C)CC1>>CCN(c1cc(Cl)cc(C(=O)NCc2c(NC)[nH]c(C)cc2=O)c1C)[C@@H]1CC[C@@H](N(C)C)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040262578A1,CCCCCCCCCCCCOS(=O)(=O)[O-].CCCC[n+]1ccn(C)c1>>CCCCCCCCCCCCOS(=O)(=O)[O-].CCCC[n+]1ccn(C)c1,,O,,[Cl-].[Na+],,val
US05028606,CC(=O)Nc1ccc(C(=O)C(C)C)cc1[N+](=O)[O-]>>CC(=O)Nc1ccc(C(O)C(C)C)cc1[N+](=O)[O-],,CO,,[BH4-].[Na+],,val
US20090270369A1,CCN=C=O.COCC(=O)NN>>CCn1c(COC)n[nH]c1=O,,Cc1ccccc1,,,,val
US20150210720A1,COc1nc(N2CCN(C)CC2)ccc1N.O=C(O)c1coc2c1C(=O)NCCC2>>COc1nc(N2CCN(C)CC2)ccc1NC(=O)c1coc2c1C(=O)NCCC2,,CC#N,O,CCN(CC)CC,CCOC(=O)Cl,val
US05403675,O=C(Cl)c1cc(Cl)ccc1Cl.c1ccc(Oc2ccccc2)cc1>>O=C(c1ccc(Oc2ccccc2)cc1)c1cc(Cl)ccc1Cl,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US05239075,CC(C)(C)c1ccc2cc(O)ccc2c1.COS(=O)(=O)OC>>COc1ccc2cc(C(C)(C)C)ccc2c1,,O,,[K+].[OH-],,val
US04521422,CC(=O)c1ccncc1.CN(C)C(OCc1ccccc1)OCc1ccccc1>>CN(C)C=CC(=O)c1ccncc1,,c1ccccc1,,,,val
US20090156600A1,COC(=O)C(C)Br.Cc1nc2c(Cl)ccc(O)c2c(C)c1Cc1ccc(Cl)cc1>>COC(=O)C(C)Oc1ccc(Cl)c2nc(C)c(Cc3ccc(Cl)cc3)c(C)c12,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050038035A1,CC(C)(C)OC(=O)Nc1cccc(CCN(C(=O)OC(C)(C)C)c2ccc(NC(=O)C3=C(c4ccc(C(F)(F)F)cc4)CCCC3)cc2)n1>>Nc1cccc(CCNc2ccc(NC(=O)C3=C(c4ccc(C(F)(F)F)cc4)CCCC3)cc2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04410520,CCOC(=O)CN1C(=O)C(N)CCc2ccccc21.O=C(O)C(O)C(O)C(=O)O>>CCOC(=O)CN1C(=O)[C@@H](N)CCc2ccccc21.O=C(O)C(O)C(O)C(=O)O,,CCO,,,,val
US20130018044A1,CCN(OCc1ccccc1)C(=O)CNC(=O)NCc1ccc(N)nc1>>CCN(O)C(=O)CNC(=O)NCc1ccc(N)nc1,[Pd],CO,,,,val
US04472408,Cl.O=C(CCC1CCCCC1)N1CC=C(c2cccc(C(F)(F)F)c2)CC1>>Cl.FC(F)(F)c1cccc(C2=CCN(CCCC3CCCCC3)CC2)c1,,O,,CCOCC,,val
US20070179191A1,CCOC(C)=O.COC(=O)CC(=O)C(C)Br.NC(=S)c1ccc(S(F)(F)(F)(F)F)cc1>>CCOC(=O)Cc1nc(-c2ccc(S(F)(F)(F)(F)F)cc2)sc1C,,CC(C)=O,,,,val
US20080176830A1,BrBr.Nc1ccc(-c2ccc(C(F)(F)F)c(F)c2)cc1F>>Nc1c(F)cc(-c2ccc(C(F)(F)F)c(F)c2)cc1Br,,CC(=O)O,,,,val
US04207321,C=CCCBr.CCCn1cnc2c1c(=O)[nH]c(=O)n2C>>C=CCCn1c(=O)c2c(ncn2CCC)n(C)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20010025043A1,CCOCC.CI.O=C1c2ccccc2C(=O)N1CCCn1cc(-c2nc3ccccc3[nH]c2=O)c2ccccc21>>CC(=O)[O-].Cn1c(=O)c(-c2cn(CCC[NH3+])c3ccccc23)nc2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20140134133A1,Clc1ccc(Cl)nn1.NNC(N)=O>>Oc1nnc2ccc(Cl)nn12,Cl,CCO,,,,val
US20110034452A1,CON(C)C(=O)c1cc(OCCCOC2CCCCO2)cc(C(C)(C)C)c1.C[Mg]Br>>CC(=O)c1cc(OCCCO)cc(C(C)(C)C)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100087419A1,CCN(C(=O)OC(C)(C)C)C(C#N)CC[C@@H](COCc1ccccc1)OC.NO>>CCN(C(=O)OC(C)(C)C)C(CC[C@@H](COCc1ccccc1)OC)C(=N)NO,,CCO,,,,val
US20150291531A1,COc1cc2c(Br)cccc2[nH]c1=O.OB(O)c1ccc(F)cc1>>COc1cc2c(-c3ccc(F)cc3)cccc2[nH]c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US04076709,COC(=O)c1sccc1O.ClP(Cl)(Cl)(Cl)Cl>>O=C(O)c1sccc1Cl,,ClC(Cl)(Cl)Cl,,,,val
US20070093521A1,C1CCNC1.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1O>>O=[N+]([O-])c1cccc(S(=O)(=O)N2CCCC2)c1O,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20110275608A1,COC(=O)c1nc(C(=O)NCC2CCN(Cc3cnc(-c4ccccn4)s3)CC2)cc(N)c1C#N.N>>N#Cc1c(N)cc(C(=O)NCC2CCN(Cc3cnc(-c4ccccn4)s3)CC2)nc1C(N)=O,,CO,,,,val
US20040072866A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1cc(C=NCC2CCNCC2)cc(-c2cccc(C#N)c2)c1>>COC(=O)c1cc(C=NCC2CCN(C(=O)OC(C)(C)C)CC2)cc(-c2cccc(C#N)c2)c1,,Cc1ccccc1,,,,val
US04743291,CC1(C)Cc2ccccc2O1.O=S(=O)(O)Cl>>CC1(C)Cc2cc(S(=O)(=O)Cl)ccc2O1,,ClC(Cl)Cl,,,,val
US20060089367A1,COc1cccc(CCN)c1.O=C(O)c1ccc2c(c1)nc(COc1ccccc1)n2Cc1ccc(OC(F)(F)F)cc1>>COc1cccc(CCNC(=O)c2ccc3c(c2)nc(COc2ccccc2)n3Cc2ccc(OC(F)(F)F)cc2)c1,,C1CCOC1,,CC(C)N=C=NC(C)C,,val
US20020007071A1,CC(C)(C)OC(=O)N1CCCC(CCCBr)C1.Clc1ccc(OCc2nc3cccc(OCc4ccccc4)c3[nH]2)cc1>>CC(C)(C)OC(=O)N1CCCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(OCc4ccccc4)cccc32)C1,,CN(C)C=O,,[H-].[Na+],,val
US20110060146A1,CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3cc(CC(=O)OC)cc(OC)c3O)c(C)c2)cc1C)CC>>CCC(O)(C=Cc1ccc(C(CC)(CC)c2ccc(-c3cc(CC(=O)OC)cc(OC)c3O)c(C)c2)cc1C)CC,,C1CCOC1,CO,[Na+].[OH-],[Cl-].[NH4+],val
US20070254931A1,CSc1cccc(Cc2sc(NC(C)=O)nc2CO)c1>>CSc1cccc(Cc2sc(NC(C)=O)nc2C=O)c1,,CO,ClC(Cl)Cl,,,val
US20070249548A1,CC1(C)OCC(CO)(Cn2cnc3c(Cl)nc(N)nc32)CO1.O=C(O)C(F)(F)F>>Nc1nc2c(ncn2CC(CO)(CO)CO)c(=O)[nH]1,,CO,,O,,val
US04491541,C1CCOC1.CCOC(=O)Cl.CN(C)C=O.CN1CCOCC1.COC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C.O=C1CC[C@@H](C(=O)N2CCC[C@H]2C(=O)O)N1>>CC(C)O.CC(C)OC(C)C.COC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCC(=O)N1)C(C)C,,C1CCOC1,CN(C)C=O,Cl,,val
US20040176601A1,Cn1c(-c2ccc(F)cc2)c(-c2cc[nH]c(=O)c2)[n+]([O-])c1-c1ccccc1>>Cn1c(-c2ccccc2)nc(-c2cc[nH]c(=O)c2)c1-c1ccc(F)cc1,,ClC(Cl)Cl,,ClP(Cl)Cl,,val
US20100168161A1,CC(=O)Cc1ccc(OCC(F)(F)c2ccccc2)cc1.C[Mg]Br>>CC(C)(O)Cc1ccc(OCC(F)(F)c2ccccc2)cc1,,CCOCC,,,,val
US20140315886A1,CCOP(=O)(OCC)C(F)(F)Br.Oc1cc(F)ccc1Br>>Fc1ccc(Br)c(OC(F)F)c1,,CC#N,O,[K+].[OH-],,val
US20090270374A1,CC(C)(C)OC(=O)NC1CCN(CCNC(=O)OCc2ccccc2)CC1>>CC(C)(C)OC(=O)NC1CCN(CCN)CC1,[Pd],CCO,,,,val
US20090105214A1,COC[C@H](C)Oc1cc(Oc2ccc3c(c2)OCCN(C)S3(=O)=O)cc(C(=O)Nc2ccn(C(=O)OC(C)(C)C)n2)c1>>COC[C@H](C)Oc1cc(Oc2ccc3c(c2)OCCN(C)S3(=O)=O)cc(C(=O)Nc2cc[nH]n2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130085132A1,CC(=O)CCC(C)=O.Nc1ccn(-c2ccccc2)n1>>Cc1ccc(C)n1-c1ccn(-c2ccccc2)n1,,CC(=O)O,,,,val
US04897405,CCOC(=O)c1ccc2c(N)cccc2c1>>Nc1cccc2cc(C(=O)O)ccc12,,C1COCCO1,,[Na+].[OH-],,val
US20120065195A1,CC(C)(C)S(N)=O.CC1(C)CC(=O)c2cc(Br)ccc2C1>>CC1(C)C/C(=N\S(=O)C(C)(C)C)c2cc(Br)ccc2C1,,CCOC(C)=O,,C1CCOC1,O=C([O-])O.[Na+],val
US20160206616A1,CCOC(=O)C1=C(C)NC(c2nccs2)=N[C@H]1c1ccc(Cl)cc1Cl.O=C1CCC(=O)N1Br>>CCOC(=O)C1=C(CBr)NC(c2nccs2)=N[C@H]1c1ccc(Cl)cc1Cl,,ClC(Cl)(Cl)Cl,,,,val
US20080139484A1,Cl[C@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1.O=Cc1c[nH]c2ccccc12>>O=Cc1cn([C@@H]2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)c2ccccc12,,CN(C)C=O,,O,[H-].[Na+],val
US05354880,CO[Si](CCC(C)(C)C#N)(OC)OC>>CO[Si](CCC(C)(C)CN)(OC)OC,[Ni],,,N,,val
US20140112945A1,COc1ccc(C2=NN(C3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.O=C(c1c[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc12)n1ccnc1>>COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](Cc4ccc(O)cc4)NC(=O)c4c[nH]c5c(-c6c(OCC7CC7)ccc7c6OCO7)ncnc45)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20090253677A1,COC(=O)C1CCC(OC)(OC)C1>>COC1(OC)CCC(CO)C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030236287A1,COc1c(F)cc([N+](=O)[O-])c(OC)c1F>>COc1c(N)cc(F)c(OC)c1F,[Pd],CCO,CCOC(C)=O,,,val
US20060166997A1,COB(OC)OC.COc1cc(Br)ccc1Cl>>COc1cc(B(O)O)ccc1Cl,,C1CCOC1,Cc1ccccc1,[Li]CCCC,,val
US20150018343A1,CC(=O)C(Cl)C(C)=O.CC(C)(C)OC(=O)N1Cc2c(N)n[nH]c2C1(C)C.Cl>>Cc1nc2c3c(nn2c(C)c1Cl)C(C)(C)NC3.Cl,,CC(=O)O,,,,val
US20090209597A1,CCOC(=O)c1cn(-c2cccc(-c3c(F)ccnc3F)c2)cn1>>O=C(O)c1cn(-c2cccc(-c3c(F)ccnc3F)c2)cn1,,CCO,,[K+].[OH-],,val
US20150191461A1,COC(=O)C1(C)CO1.Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cn[nH]c2)c1>>Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnn(CC(C)(O)C(=O)O)c2)c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20150038528A1,COC(=O)c1nc(I)c2cc(Oc3cccc4ccccc34)ccc2c1O.N#C[Cu]>>COC(=O)c1nc(C#N)c2cc(Oc3cccc4ccccc34)ccc2c1O,,CN(C)C=O,,ClCCl,,val
US20150376130A1,CC(C)(C)N.CCOC(=O)c1cccnc1Cl>>CCOC(=O)c1cccnc1NC(C)(C)C,,O,,CCO,,val
US20160083400A1,CC(C)(C)S(=O)NC1(CCN)CCc2ccccc21>>NCCC1(N)CCc2ccccc21,,C1CCOC1,,Cl,,val
US20130116243A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)NC(=S)CO4)cc2)CCC1.NNC(=O)c1ccncc1>>CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)-n3c(nnc3-c3ccncc3)CO4)cc2)CCC1,,Cc1ccc(C)cc1,,,,val
US20030125357A1,BrCCCCCBr.COc1cccc(CC#N)c1>>COc1cccc(C2(C#N)CCCCC2)c1,,CS(C)=O,,[H-].[Na+],,val
US20120245144A1,CC(C)n1ncnc1-c1cn2c(n1)-c1cc(SC3CCN(C(=O)OC(C)(C)C)CC3)ccc1OCC2>>CC(C)n1ncnc1-c1cn2c(n1)-c1cc(SC3CCNCC3)ccc1OCC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030149001A1,CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3ncc4cc(F)c(=O)n(C5CCCC5)c4n3)nc2)CC1.CC(C)CO>>CC(C)COc1cc2cnc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cn3)nc2n(C2CCCC2)c1=O,,CCCCCC,,[H-].[Na+],,val
US06169107A,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1cc2c(Cl)cc(Oc3ccc(CCl)cc3)cc2n1C.[N-]=[N+]=[N-]>>CCOC(=O)c1cc2c(Cl)cc(Oc3ccc(CNC(=O)OC(C)(C)C)cc3)cc2n1C,[Pd],CCOC(C)=O,,CN(C)C=O,,val
US04772587,CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O.COC(=O)[C@@H]1CCCN1>>COC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C,,ClCCl,,Cl,,val
US20110144105A1,CS(=O)(=O)c1ccc(C(CC2CCCC2)c2cc3cc(CO)cnc3[nH]2)cc1.O=S(Cl)Cl>>CS(=O)(=O)c1ccc(C(CC2CCCC2)c2cc3cc(CCl)cnc3[nH]2)cc1,,ClCCl,,,,val
US06984642B1,CC(C)(C)[Si](C)(C)Cl.OCCCc1nc2ccccc2[nH]1>>CC(C)(C)[Si](C)(C)OCCCc1nc2ccccc2[nH]1,,CN(C)C=O,,CCN(CC)CC,O,val
US20110172442A1,N.O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)ON1C(=O)CCC1=O)OCc1ccccc1>>NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1,,C1CCOC1,,,,val
US20060241115A1,CN.O=C(O)c1cccc2cc(Oc3ccnc(F)n3)ccc12>>CNc1nccc(Oc2ccc3c(C(=O)O)cccc3c2)n1,,C1CCOC1,,,,val
US20090197871A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cc(C)cc(C(=O)OC)c1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cc(C)cc(C(=O)O)c1,,C1CCOC1,,O,[Li+].[OH-],val
US20160198708A1,O=C(NCCc1ncc(Br)cc1Cl)c1ccccc1C(F)(F)F.OB(O)c1ccc(C(F)(F)F)nc1>>O=C(NCCc1ncc(-c2ccc(C(F)(F)F)nc2)cc1Cl)c1ccccc1C(F)(F)F,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140088117A1,Cn1ncc([N+](=O)[O-])c1C1CCC2OC2CO1.[N-]=[N+]=[N-]>>Cn1ncc([N+](=O)[O-])c1[C@@H]1CC[C@@H](N=[N+]=[N-])[C@H](O)CO1,,CO,O,[Cl-].[NH4+],,val
US20110027274A1,CC(C)(C)OC(=O)N[C@H](CO)Cc1ccc([N+](=O)[O-])cc1>>N[C@H](CO)Cc1ccc([N+](=O)[O-])cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150111869A1,COC(CC(=O)NN)c1ccc(Cl)cc1.Cn1nccc1Nc1nccc(-c2cnnc(Cl)c2)n1>>COC(Cc1nnc2cc(-c3ccnc(Nc4ccnn4C)n3)cnn12)c1ccc(Cl)cc1,,CC(C)O,,CS(=O)(=O)O,,val
US20120015962A1,CC(C)(C)[Si](C)(C)OCCCOc1ccc(Cl)cc1[N+](=O)[O-]>>Nc1cc(Cl)ccc1OCCCO,[Fe],CCO,O,[Cl-].[NH4+],,val
US20050176771A1,CC(C)(C)OC(=O)NC1CCNCC1.CCOC(=O)CF>>CC(C)(C)OC(=O)NC1CCN(C(=O)CF)CC1,,OCC(F)(F)F,,,,val
US20040215019A1,CC(C)(C)OC(=O)NCCCCN1C(=O)c2cccc(NC(=O)c3ccc(Cl)s3)c2C1=O.O=C(O)C(F)(F)F>>NCCCCN1C(=O)c2cccc(NC(=O)c3ccc(Cl)s3)c2C1=O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20070105943A1,O=C1c2ccccc2C(=O)N1CCCn1nccn1>>NCCCn1nccn1,,C1CCOC1,CO,NN,O,val
US06399660B1,CCOC(=O)COc1ccc(CCBr)c(Cl)c1.C[C@H](N)[C@H](O)c1ccc(O)cc1>>CCOC(=O)COc1ccc(CCN[C@@H](C)[C@H](O)c2ccc(O)cc2)c(Cl)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20040058978A1,CNCCc1ccc([N+](=O)[O-])cc1>>CNCCc1ccc(N)cc1,[Pd],CO,,,,val
US20080318933A1,O=S(=O)(c1ccccc1)c1ccc2c(c1)CCN2C1CCNCC1>>O=S(=O)(c1ccccc1)c1ccc2c(c1)CCN2C1CCNCC1,,CCOC(C)=O,,Cl,,val
US20090105258A1,COC(=O)C=Cc1ccc(C(C)(C)C)cc1NC(C)C>>CC(C)Nc1cc(C(C)(C)C)ccc1C=CC(=O)O,,CO,O,Cl,[Na+].[OH-],val
US05210276,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC1CCc2cc(O)ccc2C1>>CC(C)(C)OC(=O)NCC1CCc2cc(O)ccc2C1,,O,,CCN(CC)CC,CN(C)C=O,val
US05753665,CC(C)c1ccnc2ncnn12.O=C1CCC(=O)N1Br>>CC(C)(Br)c1ccnc2ncnn12,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20100323887A1,CCN(CC)CC.CCOC(=O)C(C(=O)O)c1ccccc1.CN(C)C=O.ClCCl.Clc1ccc(CNc2ccccn2)cn1.O=C(Cl)C(=O)Cl>>CCOC(=O)C(C(=O)N(Cc1ccc(Cl)nc1)c1ccccn1)c1ccccc1.CCOC(=O)C(C(=O)O)c1ccccc1,CN(C)C=O,ClCCl,,,,val
US20160009704A1,CC(C)(C)OC(=O)c1cn(CCC(F)Cn2cc(NC(=O)CN3CC(F)C3)nn2)nn1>>O=C(CN1CC(F)C1)Nc1cn(CC(F)CCn2cc(C(=O)O)nn2)nn1,,ClCCl,,O,O=C(O)C(F)(F)F,val
US20050032650A1,CCC(=O)CBr.Cc1ccc(N)nn1>>CCc1cn2nc(C)ccc2n1,,CCCO,,,,val
US20100056516A1,CCOC(=O)CC(=O)N(OCc1ccccc1)c1nccc(-c2ccccc2)c1C(=O)OC>>CCOC(=O)c1c(O)c2c(-c3ccccc3)ccnc2n(OCc2ccccc2)c1=O,,CCO,,CC(C)(C)[O-].[K+],,val
US20090209522A1,COc1nc(N2CCNC2=O)nc(OC)c1N.O=C(O)c1csc(Br)n1>>COc1nc(N2CCNC2=O)nc(OC)c1NC(=O)c1csc(Br)n1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120142659A1,CCC[C@@H](CN1CC(O)C1)N(C)C(=O)c1ccc(Cl)cc1.CCI>>CCC[C@@H](CN1CC(OCC)C1)N(C)C(=O)c1ccc(Cl)cc1,,C1CCOC1,ClCCl,[H-].[Na+],,val
US04782050,Cc1nc2ccccc2n1CF.O=[Se]=O>>O=Cc1nc2ccccc2n1CF,,C1COCCO1,,,,val
US20030216417A1,COC(=O)Cl.COc1cc2ncnc(Nc3ccc(F)c(N)c3)c2cc1OC>>COC(=O)Nc1cc(Nc2ncnc3cc(OC)c(OC)cc23)ccc1F,,ClCCl,,CCN(CC)CC,,val
US05753680,COC(=O)c1cc(S(C)(=O)=O)c(N2CCCC(O)C2)cc1C.N=C(N)N>>Cc1cc(N2CCCC(O)C2)c(S(C)(=O)=O)cc1C(=O)N=C(N)N,,CO,,O,,val
US20090088459A1,CCCI.CS(=O)(=O)c1cccc(-c2ccc(CNS(=O)(=O)c3ccccc3C(F)(F)F)s2)c1>>CCCN(Cc1ccc(-c2cccc(S(C)(=O)=O)c2)s1)S(=O)(=O)c1ccccc1C(F)(F)F,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05843983,CCOC(=O)N1C[C@H](O)C[C@H]1CCOc1cc(C)ccc1CCc1ccccc1>>Cc1ccc(CCc2ccccc2)c(OCC[C@@H]2C[C@@H](O)CN2C)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120157449A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CCN2CCCCC2c2ccoc3cccc2-3)CC1.Cl.ClCCl>>Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCCCC2c2ccoc3cccc2-3)CC1,,ClCCl,,,,val
US05444080,CCCCc1ncc(CC=CCCC(=O)O)n1Cc1ccccc1Cl.CO>>CCCCc1ncc(CCCCCC(=O)OC)n1Cc1ccccc1Cl,O=[Pt],,,Cl,[H][H],val
US20120050945A1,C1CCCNCC1.COCCBr>>COC(C)N1CCCCCC1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20020040025A1,CCI.CCOC(=O)c1nccc(-c2ccc(Oc3ccc(F)cc3)cc2)n1.O=C(O)c1nccc(-c2ccc(Oc3ccc(F)cc3)cc2)n1>>CC(=O)c1nccc(-c2ccc(Oc3ccc(F)cc3)cc2)n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04443605,COc1ccc2c3c1O[C@H]1C(=O)C(COS(=O)(=O)c4ccc(C)cc4)(COS(=O)(=O)c4ccc(C)cc4)C[C@H]4[C@@H](C2)N(C)CC[C@]314>>COc1ccc2c3c1O[C@H]1[C@@H](O)C(COS(=O)(=O)c4ccc(C)cc4)(COS(=O)(=O)c4ccc(C)cc4)C[C@H]4[C@@H](C2)N(C)CC[C@@]341,,CCO,ClC(Cl)Cl,CC(=O)O,[BH4-].[Na+],val
US07053099B1,C1CCOC1.NCc1c(Nc2c(F)cccc2F)cccc1Oc1ccccc1.O=C(n1ccnc1)n1ccnc1>>O=C(O)n1ccnc1.[NH-]c1c(Nc2c(F)cccc2F)cccc1Oc1ccccc1,,C1CCOC1,,,,val
US05412104,CCCCCCCn1c(=O)c(C(=O)OCC)c(OC)c2ccccc21.[Li]C>>CCCCCCCn1c(=O)c(C(C)=O)c(OC)c2ccccc21,[Cu]I,C1CCOC1,,,,val
US05585378,O=C1Nc2ccc(C3CCCCC3)cc2C1=O.OCCO>>O=C1Nc2ccc(C3CCCCC3)cc2C12OCCO2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US05519133,COC(=O)Cn1c(=O)n(C)c(=O)n(-c2cc(F)ccc2[N+](=O)[O-])c1=O.Cc1c(Cl)ccc(O)c1Cl>>COC(=O)Cn1c(=O)n(C)c(=O)n(-c2cc(Oc3c(Cl)ccc(C)c3Cl)ccc2[N+](=O)[O-])c1=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090099355A1,COP([O-])OC.O=S(=O)(Oc1ccc(Cl)cc1)C(F)(F)F>>COP(=O)(OC)c1ccc(Cl)cc1,,Cc1ccccc1,,CCN(CC)CC,,val
US06107319,CC(C)[Si](Cl)(C(C)C)C(C)C.Sc1ccc(Br)cc1>>CC(C)[Si](Sc1ccc(Br)cc1)(C(C)C)C(C)C,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20150148327A1,Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc(CBr)nc2)c1.O=C1CCCN1>>Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc(CN3CCCC3=O)nc2)c1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20130210819A1,Cc1nc2cc(-c3ccc4ncnc(N5CCC(=O)c6ccccc65)c4c3)cnc2n1COCC[Si](C)(C)C>>Cc1nc2cc(-c3ccc4ncnc(N5CCC(=O)c6ccccc65)c4c3)cnc2[nH]1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130085154A1,CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2.O=[N+]([O-])O>>CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2.O=[N+]([O-])[O-],,CC(C)=O,,CCCCCCC,,val
US20110190297A1,NC(=S)C1CCN(c2c(Cl)cncc2Cl)CC1.O=CCCl>>Clc1cncc(Cl)c1N1CCC(c2nccs2)CC1,,CCO,,,,val
US20160002188A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(O)c1ccc(-c2ccc(Br)cc2)cc1>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(-c3ccc(Br)cc3)cc2)CC1,,CN(C)C=O,O,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US05786350,CCOC(=O)c1cn(C2CC2)c2cc(Br)c(F)cc2c1=O.Cc1cc([Sn](C)(C)C)cc(C)n1>>CCOC(=O)c1cn(C2CC2)c2cc(-c3cc(C)nc(C)c3)c(F)cc2c1=O,,C1COCCO1,O,,,val
US20070037807A1,Cc1ccc(-c2c(CNC(=O)OC(C)(C)C)c(CC(C)C)nc(C)c2C(=O)O)cc1.O=C1O/C(=C/CCl)c2ccccc21>>Cc1ccc(-c2c(CNC(=O)OC(C)(C)C)c(CC(C)C)nc(C)c2C(=O)OC/C=C2/OC(=O)c3ccccc32)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20150152047A1,CCOC(=O)c1ccc(CN2CCC[C@H](NC(=O)OC(C)(C)C)C2)c(C(F)(F)F)c1.CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CC[C@@H](NC(=O)OC(C)(C)C)C2)c(C(F)(F)F)c1>>CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCC[C@H](N)C2)c(C(F)(F)F)c1,,ClCCl,,,,val
US20090227628A1,CCNCC.COC(=O)CCCc1cccc2nc(NCc3ccc(C)o3)ccc12>>CCN(CC)C(=O)CCCc1cccc2nc(NCc3ccc(C)o3)ccc12,,C1COCCO1,,C[Al](C)C,,val
US20130102776A1,CI.O=C1COc2c1ccc(O)c2I>>COc1ccc2c(c1I)OCC2=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060122181A1,CCCC(CCC)c1ccc(COc2ccc(-c3csc(COC(=O)c4ccccc4)n3)cc2)cc1>>CCCC(CCC)c1ccc(COc2ccc(-c3csc(CO)n3)cc2)cc1,,C1CCOC1,,CO,[Na+].[OH-],val
US20100179216A1,O=C1CCC(=O)N1Br.OCCCCC1CCCCC1>>BrCCCCC1CCCCC1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060194836A1,O=C(Nc1ccc(S(=O)(=O)C(F)(F)F)cc1)c1cccnc1Cl.SCc1ccncc1>>O=C(Nc1ccc(S(=O)(=O)C(F)(F)F)cc1)c1cccnc1SCc1ccncc1,,CCO,CCOC(C)=O,Cl,O=C([O-])[O-].[K+].[K+],val
US05001125,CO.Cc1cccc(N2CCN(c3ccc(Cl)nn3)CC2)c1>>COc1ccc(N2CCN(c3cccc(C)c3)CC2)nn1,,O,,[Na],C[O-].[Na+],val
US20080242655A1,C#CCBr.CCOC(=O)c1[nH]c2ccncc2c1Nc1ccc(I)cc1F>>C#CCn1c(C(=O)OCC)c(Nc2ccc(I)cc2F)c2cnccc21,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20040242627A1,BrCc1ccccc1.Nc1nc2ccccc2[nH]1>>Nc1nc2ccccc2n1Cc1ccccc1,,CCO,,[K+].[OH-],,val
US20060241110A1,CC(C)(C)OC(=O)N1CC(Oc2cc(F)cc([N+](=O)[O-])c2)CC1C(C)(C)O[SiH2]C(C)(C)C>>CC(C)(C)OC(=O)N1CC(Oc2cc(F)cc([N+](=O)[O-])c2)CC1CO,,CO,,Cl,O=C([O-])O.[Na+],val
US20050234101A1,O=C(OCc1ccccc1)N1CCC(C(=O)C(F)(F)F)CC1>>O=C(C1CCNCC1)C(F)(F)F,,CCOC(C)=O,CO,N,,val
US05364943,COc1ccccc1C=O.Nc1cccnc1Cl>>COc1ccccc1CNc1cccnc1Cl,,CC(=O)O,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20030171418A1,COc1ccc2[nH]nc(C[C@@H](C)O)c2c1>>C[C@@H](O)Cc1n[nH]c2ccc(O)cc12,,ClCCl,,,,val
US04610716,CC(C)(C)C(=O)C(F)Oc1ccc(Cl)cc1.C[S+](C)(C)=O>>CC(C)(C)C1(C(F)Oc2ccc(Cl)cc2)CO1,,C1CCOC1,CS(C)=O,[H-].[Na+],,val
US20050020587A1,CC(=O)N1CCC(NC(=O)c2cc(F)cnc2Cl)CC1.CSc1ccc(O)cc1C>>CSc1ccc(Oc2ncc(F)cc2C(=O)NC2CCN(C(C)=O)CC2)cc1C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150018363A1,CN(C)C=O.FC(F)(F)c1ccsc1>>OCc1cc(C(F)(F)F)cs1,,C1CCOC1,,CC1(C)CCCC(C)(C)N1,[Li]CCCC,val
US20140309193A1,CC(C)COC(=O)Cl.CCOC(=O)c1c(O)c(O)c(C(=O)N(C)C)n1-c1ccc(OC)cc1.CN1CCOCC1.COCCC(=O)O>>CCOC(=O)c1c(OC(=O)CCOC)c(OC(=O)CCOC)c(C(=O)N(C)C)n1-c1ccc(OC)cc1,,ClCCl,,,,val
US20100331346A1,COc1cc(C(N)CC(=O)O)cc(OC)c1OC.O=Cc1ccccc1C=O>>COc1cc(C(CC(=O)O)N2Cc3ccccc3C2=O)cc(OC)c1OC,,ClCCl,,CC(=O)O,,val
US20140051672A1,CC1(C)OB(c2cn[nH]c2)OC1(C)C.COc1cc(Cl)ccc1-c1ccc(OC2CC(C)(C)NC(C)(C)C2)nn1>>COc1cc(-c2cn[nH]c2)ccc1-c1ccc(OC2CC(C)(C)NC(C)(C)C2)nn1,[Pd],CCO,O,O=C([O-])[O-].[K+].[K+],,val
US20060004018A1,CC(C)[C@]1(C(=O)N2CC=C(c3ccccc3)CC2)CC[C@@H](NC2CCOCC2)C1>>CC(C)[C@]1(C(=O)N2CCC(c3ccccc3)CC2)CC[C@@H](NC2CCOCC2)C1,[Pd],CO,,,,val
US20110039847A1,CN(C)CCN.Cc1nnc(-c2ccccc2NC(=O)c2cc(Cl)nc(-c3ccccc3)n2)o1>>Cc1nnc(-c2ccccc2NC(=O)c2cc(NCCN(C)C)nc(-c3ccccc3)n2)o1,,C1CCOC1,O,,,val
US20150376130A1,COC(=O)c1cc(F)cnc1Nc1cccc(F)c1>>O=C(O)c1cc(F)cnc1Nc1cccc(F)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20100035883A1,COC(=O)c1cccc2c1C(=O)C(c1cncs1)C(c1ccccc1)N2.NN>>O=c1[nH]nc2c3c(cccc13)NC(c1ccccc1)C2c1cncs1,,CO,,O,,val
US20110046378A1,CC(C)(C)OC(=O)Nc1ccc2c(c1)[nH]c1cc(OCc3ccccc3)ccc12>>CC(C)(C)OC(=O)Nc1ccc2c(c1)[nH]c1cc(O)ccc12,[Pd],CO,,,,val
US03937722,CC(O)(C(=O)c1ccccc1)c1ccccc1.COS(=O)(=O)c1ccc(C)cc1>>COC(C)(C(=O)c1ccccc1)c1ccccc1,,CS(C)=O,,[Na+].[OH-],,val
US20120238539A1,COc1ccccc1-c1noc(C)c1C(=O)N1CCN(c2cc(NC(=O)c3ccc(N(C)C)cc3)c(CO)cc2Cl)CC1>>COc1ccccc1-c1noc(C)c1C(=O)N1CCN(c2cc(NC(=O)c3ccc(N(C)C)cc3)c(C=O)cc2Cl)CC1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US05047411,Cc1ccn2cc(CSC(=N)N)nc2c1>>Cc1ccn2cc(CS)nc2c1,,O,,Cl,[Na+].[OH-],val
US20060252779A1,CSC1=Nc2ccccc2CN1.I.NCCOc1ccccc1>>I.c1ccc(OCCNC2=Nc3ccccc3CN2)cc1,,CC#N,,,,val
US20160243100A1,Nc1ccon1.O=C(Cl)Oc1ccccc1>>O=C(Nc1ccon1)Oc1ccccc1,,CC#N,,c1ccncc1,,val
US20040038965A1,C[C@@H]1CC[C@H](NC(=O)C2(NC(=O)OC(C)(C)C)CCCCC2)[C@@H](O)CN1C(=O)OCc1ccccc1>>C[C@@H]1CC[C@H](NC(=O)C2(NC(=O)OC(C)(C)C)CCCCC2)[C@@H](O)CN1,[Pd],CCO,,[H][H],,val
US20160194328A1,CC(C)N.Nc1nccc2c1nc(Sc1cccc3ccccc13)n2CCCBr>>CC(C)NCCCn1c(Sc2cccc3ccccc23)nc2c(N)nccc21,,CN(C)C=O,,,,val
US20150183791A1,CC(=O)c1ccc(B(O)O)s1.Clc1ccc2ncc(Br)n2n1>>CC(=O)c1ccc(-c2cnc3ccc(Cl)nn23)s1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20030236270A1,COc1cccc2cc(C#N)ccc12.O.[OH-]>>COc1cccc2cc(C(=O)O)ccc12,,CCO,,Cl,,val
US20160207928A1,C[S-].Fc1ccc(Br)c(OCC(F)(F)F)c1>>CSc1ccc(Br)c(OCC(F)(F)F)c1,,CN(C)C=O,,O,,val
US20070185119A1,CN(C)c1nc(N[C@H]2CCC[C@H](N)C2)nc2ccccc12.Cn1cc(C=O)c2ccccc21>>CN(C)c1nc(N[C@H]2CCC[C@H](NCc3cn(C)c4ccccc34)C2)nc2ccccc12,,C1CCOC1,ClCCCl,O=C([O-])O.[Na+],,val
US05550125,O=C(c1cccc(C(F)(F)F)c1)N1c2cc(F)ccc2OCC1CCO.O=S(Cl)Cl>>O=C(c1cccc(C(F)(F)F)c1)N1c2cc(F)ccc2OCC1CCCl,,ClCCl,,,,val
US20040204498A1,CCOC(=O)c1nc(S(C)(=O)=O)n(C)c(=O)c1OCc1ccccc1.CN>>CCOC(=O)c1nc(NC)n(C)c(=O)c1OCc1ccccc1,,C1CCOC1,CC#N,CCN(C(C)C)C(C)C,,val
US20080319005A1,CCOC(=O)Cc1ccc(-n2cnc3cc(-c4ccc(OC)cc4)ccc32)cc1>>COc1ccc(-c2ccc3c(c2)ncn3-c2ccc(CC(=O)O)cc2)cc1,,CO,ClCCl,,,val
US20010011094A1,Clc1cc(Cl)nc(Cl)n1.Oc1c(Cl)cccc1Cl>>Clc1cc(Oc2c(Cl)cccc2Cl)nc(Cl)n1,,C1CCOC1,,CCO,[K+].[OH-],val
US04122090,C1CCOC1.CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)N>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.COC(=O)[C@@H](N)Cc1ccccc1.C[C@H](N)C(=O)O,,C1CCOC1,,CCN(CC)CC,Cl,val
US05360802,CN1C(=O)C(NC(=O)Oc2ccc([N+](=O)[O-])cc2)N=C(C2CCCCC2)c2ccccc21.CS(=O)(=O)NC(=O)c1cccc([N+](=O)[O-])c1>>CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)(C2CCCCC2)N=Cc2ccccc21,,CN(C)C=O,,CCN(CC)CC,,val
US20140275071A1,CC(C)(C)OC(=O)CCBr.Cn1c(=O)[nH]c(=O)c2c1nc(Oc1cccc(OC(F)(F)F)c1)n2Cc1ccc(Cl)cc1>>Cn1c(=O)n(CCC(=O)OC(C)(C)C)c(=O)c2c1nc(Oc1cccc(OC(F)(F)F)c1)n2Cc1ccc(Cl)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20140114067A1,COC(=O)CBr.c1ccc(-c2nc3ccccc3[nH]2)cc1>>COC(=O)Cn1c(-c2ccccc2)nc2ccccc21,,O,,CN(C)C=O,[H-].[Na+],val
US20130237501A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3cc(Cl)c(Br)c(COCOC)c3)S(C)(=O)=O)c(C3CC3)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3cc(Cl)c(B4OC(C)(C)C(C)(C)O4)c(COCOC)c3)S(C)(=O)=O)c(C3CC3)cc12,,C1COCCO1,CCOC(C)=O,CC(=O)[O-].[K+],,val
US20060287363A1,CN1CCC(=O)CC1.ClCCCl.Nc1cc(NC(=O)c2ccc(F)cc2Cl)ccc1F>>CN1CCC(Nc2cc(NC(=O)c3ccc(F)cc3Cl)ccc2F)CC1.Cl,,CCOC(C)=O,ClCCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040171881A1,CCCCN1CCOc2c(C#N)cc(C(=O)O)cc21.CCc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1>>CCCCN1CCOc2c(C#N)cc(C(=O)N[C@@H](Cc3cc(F)cc(F)c3)[C@H](O)CNCc3cccc(CC)c3)cc21,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080293749A1,Cl.O=C1CC(N2C=Nc3cccc(O)c3C2)C(=O)N1>>Cl.O=C1CC(N2C=Nc3cccc(O)c3C2)C(=O)N1,,CC(=O)O,CCOCC,,,val
US05128338,Nc1nc(=O)[nH]c2ccccc12.O=C(CBr)c1ccccc1>>O=c1[nH]c2ccccc2c2nc(-c3ccccc3)cn12,,O,,CN(C)C=O,,val
US20050240021A1,COc1cc(C(=O)C(C)Br)ccc1-c1ccccn1.Nc1nccs1>>COc1cc(-c2nc3sccn3c2C)ccc1-c1ccccn1,,CCO,,,,val
US20140256700A1,Cc1noc(C)c1-c1cc(C(N)=O)c2c(c1)[nH]c1ccc(C(=O)N3C[C@H](C)O[C@H](C)C3)cc12.O=C(Cl)c1ccccc1>>Cc1noc(C)c1-c1cc(C(N)=O)c2c3cc(C(=O)N4C[C@H](C)O[C@H](C)C4)ccc3n(C(=O)c3ccccc3)c2c1,,CN(C)C=O,,[H-].[Na+],,val
US06350749B1,CCc1cn(S(C)(=O)=O)c2c1C(=O)CC(c1ccccc1)C2.Cl.N=C(N)NN>>CCc1cn(S(C)(=O)=O)c2c1C(=NNC(=N)N)CC(c1ccccc1)C2.Cl,,CCO,,Cl,O,val
US20120149676A1,CC(C)(O)C1CCNCC1.CNc1cc(F)c(C(=O)NCC(F)(F)F)cc1[N+](=O)[O-]>>CNc1cc(N2CCC(C(C)(C)O)CC2)c(C(=O)NCC(F)(F)F)cc1[N+](=O)[O-],,CCOC(C)=O,,C1CCOC1,[H-].[Na+],val
US20110201640A1,CCCc1nc2cccc(C(=O)OC)c2[nH]1.CCOC(C)=O>>CCCc1nc2cccc(CC(C)O)c2[nH]1,,C1CCOC1,,O,,val
US20150080365A1,Cc1cc(F)nc(N2CCN(C(=O)OC(C)(C)C)CC2)c1.ClCCl>>Cc1cc(F)nc(N2CCNCC2)c1.Cl,,O=C(O)C(F)(F)F,,,,val
US06017919,CCCCCBr.COc1ccc(C=O)c(Br)c1O>>CCCCCOc1c(OC)ccc(C=O)c1Br,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070213397A1,CCN(CCCNC(=O)OC(C)(C)C)Cc1c2ccccc2cc2ccccc12.Cl>>CCN(CCCN)Cc1c2ccccc2cc2ccccc12.Cl,,CCO,,,,val
US04337259,COc1ccccc1S.Cl.ClCc1ccccn1>>COc1ccccc1SCc1ccccn1.Cl,,CCO,,[Na+].[OH-],,val
US04581456,C=O.CCCC1(c2cccc(OC)c2)C=CN(C)CC1.CCCC1(c2cccc(OC)c2)C=CN(C)CC1.CNC.O=S(=O)(O)O>>CCCC1(c2cccc(OC)c2)C=CN(C)CC1.CCCC1(c2cccc(OC)c2)CCN(C)C=C1CN(C)C.O=S(=O)(O)O,,CCCCCC,O,O=S(=O)(O)O,[Na+].[OH-],val
US20090275574A1,N[C@@H]1CC2(CC[C@H]1O)OCCO2.O=C1CCN(C(=O)OCc2ccccc2)CC1>>O=C(OCc1ccccc1)N1CCC(N[C@@H]2CC3(CC[C@H]2O)OCCO3)CC1,,ClCCl,,O=C([O-])O.[Na+],,val
US05055606,C=CC(=O)O.CCCCCCCCS>>CCCCCCCCCCC(O)=S,,CC(C)O,O,O=S(=O)(O)O,[Na+].[OH-],val
US20110178060A1,Cc1cc(F)ccc1[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1C(=O)O.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cc1cc(F)ccc1[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1N,,Cc1ccccc1,O,CCN(CC)CC,[Na+].[OH-],val
US20080312322A1,COC(=O)COc1ccccc1Cc1cc(Cl)ccc1OCC(=O)OC>>O=C(O)COc1ccccc1Cc1cc(Cl)ccc1OCC(=O)O,,CO,,[Na+].[OH-],,val
US06403602B1,CC(C)C(=O)OC(=O)C(C)C.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5>>CC(C)C(=O)Oc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341,,CO,ClC(Cl)Cl,,,val
US05310735,CC(O)=S.CS(=O)(=O)O[C@@H]1C[C@@H](C(=O)N2CCN(CCOC(=O)OCc3ccc([N+](=O)[O-])cc3)CC2)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1>>CC(=O)S[C@H]1C[C@@H](C(=O)N2CCN(CCOC(=O)OCc3ccc([N+](=O)[O-])cc3)CC2)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20030073696A1,CCN=C=NCCCN(C)C.On1nnc2ccccc21.c1ccncc1>>NC(=O)/C=C/c1ccccc1,,c1ccncc1,,Cl,O,val
US20160052926A1,CNC(=O)c1cc(CCc2cnc(Nc3cnn([C@@H]4CCCN(C(=O)OC(C)(C)C)C4)c3)nc2)c(F)c(OC)c1>>CNC(=O)c1cc(CCc2cnc(Nc3cnn([C@@H]4CCCNC4)c3)nc2)c(F)c(OC)c1,Cl,CO,,,,val
US05607960,C=CC(O)(CC)CC.O=C(OCc1ccccc1)N1CCC[C@@H]1Cc1c[nH]c2ccc(Br)cc12>>CCC(O)(C=Cc1ccc2[nH]cc(C[C@H]3CCCN3C(=O)OCc3ccccc3)c2c1)CC,,CO,,,,val
US20110076291A1,CCN=C=O.Cc1nc(-c2nc3c(s2)CCOc2cc(CN)ccc2-3)n(C(C)C)n1>>CCNC(=O)NCc1ccc2c(c1)OCCc1sc(-c3nc(C)nn3C(C)C)nc1-2,,C1CCOC1,,CCN(CC)CC,,val
US20020013295A1,COC(=O)c1ccc(CCSC(C)=O)c(C(=O)OC)c1>>O=C(O)c1ccc(CCS)c(C(=O)O)c1,,C1CCOC1,O,[Na+].[OH-],,val
US20110281854A1,C[C@@H]1CN[C@H](c2ccccc2)CO1.O=C1COc2cnc(Cl)cc2N1>>C[C@@H]1CN(c2cc3c(cn2)OCC(=O)N3)[C@H](c2ccccc2)CO1,,CS(C)=O,,,,val
US20060084681A1,CC(C)(C)OC(=O)CCNC(=O)c1ccc(Cn2nc(-c3cc(Cl)cc(Cl)c3)cc2-c2ccc(Br)cc2)cc1>>O=C(O)CCNC(=O)c1ccc(Cn2nc(-c3cc(Cl)cc(Cl)c3)cc2-c2ccc(Br)cc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120197027A1,COCCO.COc1cc2c(Nc3ccc4[nH]ccc4c3)ncnc2cc1O>>COCCOc1cc2ncnc(Nc3ccc4[nH]ccc4c3)c2cc1OC,,COCCO,,,,val
US05110955,CC(=O)OC(C)=O.COc1c(C)c(C)c(OC)c(CC/C(C)=C/CO)c1C>>COc1c(C)c(C)c(OC)c(CC/C(C)=C/COC(C)=O)c1C,,c1ccncc1,,,,val
US20100021423A1,COc1ncccc1-c1cc(Cc2ccccc2)cc(C(C)(C)C)c1>>CC(C)(C)c1cc(Cc2ccccc2)cc(-c2ccc[nH]c2=O)c1,,CC(=O)O,,Br,O=C([O-])O.[Na+],val
US20040058322A1,COC(OC)c1ccccc1.OCCCCC(O)CO>>OCCCCC1COC(c2ccccc2)O1,,CCOC(C)=O,CN(C)C=O,,,val
US20120264735A1,Cn1cc(-n2ccc(=O)c(Cc3cccc(-c4ncc(O)cn4)c3)n2)cn1.FC(F)(CI)CN1CCOCC1>>Cn1cc(-n2ccc(=O)c(Cc3cccc(-c4ncc(OCC(F)(F)CN5CCOCC5)cn4)c3)n2)cn1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20030220341A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1CCCC(N)C1>>CC(C)(C)OC(=O)NC1CCCC(N)C1,,ClC(Cl)Cl,,,,val
US03932432,CC(CCCc1ccc(F)cc1)C1=CC(O)(O)C2=C3CNCCC3C(C)(C)OC2=C1.COc1cc(C=CCCl)cc(OC)c1OC>>COc1cc(C=CCN2CCC3C(=C4C(=CC(C(C)CCCc5ccc(F)cc5)=CC4(O)O)OC3(C)C)C2)cc(OC)c1OC,,CN(C)C=O,,,,val
US20080275046A1,Cc1nc(-c2ccc(OCCCCl)cc2)sc1CO.O=C1CCCN1>>Cc1nc(-c2ccc(OCCCCl)cc2)sc1CN1CCCC1=O,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120263679A1,C=COCCON.COC(=O)c1ccc(=O)n(C)c1Nc1ccc(C)cc1F>>C=COCCONC(=O)c1ccc(=O)n(C)c1Nc1ccc(C)cc1F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05712393,Nc1c(I)cc(Br)cc1S(=O)(=O)O.O=[N+]([O-])c1cccc(B(O)O)c1>>Nc1c(-c2cccc([N+](=O)[O-])c2)cc(Br)cc1S(=O)(=O)O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20080306045A1,C=O.O=C1[C@@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)CCN1c1ccc2c(c1)CCCNC2.O=CO>>CN1CCCc2cc(N3CC[C@H](NS(=O)(=O)c4ccc5cc(Cl)ccc5c4)C3=O)ccc2C1.O=CO,,ClC(Cl)Cl,,Cl,,val
US05604229,C1=COCCC1.CCCCCCCCCCCC(O)O>>CCCCCCCCCCCC(O)OC1CCCCO1,Cc1ccc(S(=O)(=O)O)cc1,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20120142706A1,Clc1cnc(Cl)cn1.c1nc[nH]n1>>Clc1cnc(-n2cncn2)cn1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20100087427A1,CCOc1ccccc1CN=C=O.COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2O)C(C)C)ccc1OC>>CCOc1ccccc1CNC(=O)O[C@@H]1CNC[C@H]1CN(C(=O)c1ccc(OC)c(OCCCOC)c1)C(C)C,,O,,CC#N,CC#N,val
US04251530,Clc1cncc(N2CCNCC2)n1.O=c1n(CCCCl)nc2ccccn12>>Cl.O=c1n(CCCN2CCN(c3cncc(Cl)n3)CC2)nc2ccccn12,,CCN(CC)CC,,Cc1ccccc1,,val
US20040009993A1,Cc1nc(N2CCN(c3ccccc3)CC2)nc2c1ccc(=O)n2-c1ccc(C(=O)Cl)cc1.NCc1ccccc1>>Cc1nc(N2CCN(c3ccccc3)CC2)nc2c1ccc(=O)n2-c1ccc(C(=O)NCc2ccccc2)cc1,,ClCCl,O,CCN(CC)CC,,val
US20100311714A1,Cc1c(OC(C)C)cc(Br)c[n+]1[O-]>>CC(C)Oc1cc(Br)cnc1CO,,C1CCOC1,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20030018026A1,COC[C@H]1CO1.Cc1cc(C(=O)N2Cc3ccc(C(=O)N4CCNCC4)n3Cc3ccccc32)ccc1-c1ccccc1C(F)(F)F>>COC[C@H](O)CN1CCN(C(=O)c2ccc3n2Cc2ccccc2N(C(=O)c2ccc(-c4ccccc4C(F)(F)F)c(C)c2)C3)CC1,,CO,,CCN(C(C)C)C(C)C,Cl,val
US20150111914A1,CN(C)C(=O)c1cc2cc(CO)cnc2o1.COc1ccc(CCl)cc1>>COc1ccc(COCc2cnc3oc(C(=O)N(C)C)cc3c2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05177069,O=C(O)CCC(CSc1ccc2ccccc2c1)C(=O)O.OCc1ccccc1>>O=C(CCC(CSc1ccc2ccccc2c1)C(=O)O)OCc1ccccc1,,CC#N,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150119362A1,Clc1cc(Cl)c2c(n1)CCC2.OB(O)c1cncc(Cl)c1>>Clc1cncc(-c2cc(Cl)c3c(n2)CCC3)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[Cs+].[Cs+],val
US05594003,CCCc1nc2c(C)cc(-c3nc4ccccc4[nH]3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCc1nc2c(C)cc(-c3nc4ccccc4[nH]3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100159596A1,COC(=O)c1ccc(OC)cc1C(C)=O.NN>>COc1ccc2c(=O)[nH]nc(C)c2c1,,CO,O,,,val
US20130053364A1,COC(=O)C1CCN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCC1C(=O)O,,C1COCCO1,O,[Li+].[OH-],,val
US20100280001A1,COC(=O)Cc1ccc(C=O)cc1.COCCc1nc2c(N)nc3ccccc3c2n1CCCN>>COCCc1nc2c(N)nc3ccccc3c2n1CCCNCc1ccc(CC(=O)OC)cc1,CC(=O)O,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US06627651B1,Cc1ccc(C2=Cc3cc(Br)ccc3OC2)cc1.O=C=O>>Cc1ccc(C2=Cc3cc(C(=O)O)ccc3OC2)cc1,,C1CCOC1,CCCCCC,Cl,[Li]CCCC,val
US20160038504A1,C1CC2COCC1N2.Cn1c(Cl)cc(Br)cc1=O>>Cn1c(Cl)cc(N2C3CCC2COC3)cc1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20140142126A1,CC(C)(C)OC(=O)Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)c(Br)n2[C@@H]1CCN(C(=O)OC(C)(C)C)C1.CN(C)C=O>>CC(C)(C)OC(=O)Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)c(C=O)n2[C@@H]1CCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,[Li]CCCC,,val
US20100016319A1,CC(C)(C)c1csc(NC(=O)NCc2ccccc2O)n1.Clc1ccnc(Cl)n1>>CC(C)(C)c1csc(NC(=O)NCc2ccccc2Oc2ccnc(Cl)n2)n1,,CC(C)=O,,[Na+].[OH-],,val
US20160229853A1,CC(C)(C)[Si](C)(C)OCc1cc2cc(Cl)cc(F)c2n1C1CCS(=O)(=O)C1>>O=S1(=O)CCC(n2c(CO)cc3cc(Cl)cc(F)c32)C1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20060142336A1,Cc1cc(COC2CCN(S(=O)(=O)CC(C(=O)OC(C)(C)C)C3CCCC3)CC2)c2ccccc2n1>>Cc1cc(COC2CCN(S(=O)(=O)CC(C(=O)O)C3CCCC3)CC2)c2ccccc2n1,,CO,,Cl,,val
US20100234395A1,BrCCOCc1ccccc1.COC(=O)Cc1ccc(O)cc1>>COC(=O)Cc1ccc(OCCOCc2ccccc2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20130296377A1,CI.COc1cc(C)c2c(ccn2C(=O)OC(C)(C)C)c1C(C)(O)c1nc2cc(C#N)ccc2o1>>COc1cc(C)c2c(ccn2C(=O)OC(C)(C)C)c1C(C)(OC)c1nc2cc(C#N)ccc2o1,,CN(C)C=O,,[H-].[Na+],,val
US05866566,CI.NC(=O)N1c2ccccc2CC(=NO)c2ccccc21>>CON=C1Cc2ccccc2N(C(N)=O)c2ccccc21,,CC(C)=O,O,[K+].[OH-],,val
US20070032517A1,CC(=O)Cl.Cc1c(N)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2n(CC(C)C)c1=O>>CC(=O)Nc1c(C)c(=O)n(CC(C)C)c2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc12,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20160229856A1,Cn1cc(NC(=O)c2cccc(-c3cn[nH]c3)n2)c(C(=O)NCCCCCCBr)n1>>Cn1cc2c(n1)C(=O)NCCCCCCn1cc(cn1)-c1cccc(n1)C(=O)N2,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([C@H](O)c4ccccn4)cc2)CCN3C=O)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([C@H](O)c4cccc[n+]4[O-])cc2)CCN3C=O)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20070179143A1,COC(=O)c1cccc(CCO)c1>>O=C(O)c1cccc(CCO)c1,,CO,,[Na+].[OH-],,val
US20020103253A1,Cc1ccc(NC(=O)Nc2cc(C(C)(C)C)sc2CNC(=O)CNC(=O)OC(C)(C)C)cc1>>Cc1ccc(NC(=O)Nc2cc(C(C)(C)C)sc2CNC(=O)CN)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120309738A1,CC(C)(C)C(=O)Cl.NCc1ccc(OC(F)(F)F)cc1>>CC(C)(C)C(=O)NCc1ccc(OC(F)(F)F)cc1,,CC#N,,,,val
US05631208,COC(Cl)Cl.Cc1ccc(C)c2c1CC(C)(C)O2>>Cc1cc(C=O)c(C)c2c1OC(C)(C)C2,,ClCCl,,,,val
US05475042,CC(c1cc(C(C)(C)C)cc(C(C)(C)C)c1O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1O.ClP(Cl)Cl>>CC1c2cc(C(C)(C)C)cc(C(C)(C)C)c2OP(Cl)Oc2c1cc(C(C)(C)C)cc2C(C)(C)C,,Cc1ccccc1,,CN1CCCC1=O,,val
US20100184815A1,CC(C)(C)OC(=O)C(C)(C)Sc1ccc(C(=O)O)cc1.Cc1ccc(Cn2cc(CO)nn2)cc1>>Cc1ccc(Cn2cc(COC(=O)c3ccc(SC(C)(C)C(=O)OC(C)(C)C)cc3)nn2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US03954844,CC(=O)OC(C)=O.CCCCC[C@H](O)/C=C/[C@H]1C2OC2C(=O)[C@@H]1C/C=C\CCCC(=O)O>>CCCCC[C@@H](/C=C/[C@H]1C2OC2C(=O)[C@@H]1C/C=C\CCCC(=O)O)OC(C)=O,,O,,c1ccncc1,,val
US20130029995A1,Nc1cc2ccccc2cn1.O=C(Cl)Oc1ccccc1>>O=C(Nc1cc2ccccc2cn1)Oc1ccccc1,,CC#N,O,c1ccncc1,,val
US20130296555A1,C/C(=N/O)NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OCc1ccccc1>>Cc1noc([C@@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)n1,,CN(C)C=O,,,,val
US20110009454A1,Cc1ccccc1O.N#Cc1cccc(F)c1>>Cc1ccccc1Oc1cccc(C#N)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20130102611A1,CCOC(=O)CCCCCCN1CCCc2nc(-c3ccncc3)c(-c3ccc(C)cc3)nc21>>Cc1ccc(-c2nc3c(nc2-c2ccncc2)CCCN3CCCCCCC(=O)O)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US05030629,CC(C)(N)CN.CCCCCC#N>>CCCCCC1=NC(C)(C)CN1,,S=C=S,,,,val
US20090197871A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CO)c3)c2)c1.II>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CI)c3)c2)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20010051731A1,Nc1ccc(C(CC2CCCC2)C(=O)Nc2nccs2)cc1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>O=C(Nc1nccs1)C(CC1CCCC1)c1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20150315197A1,CC(C)(C)OC(=O)N1CCc2c(C(=O)N3CCC(c4cc(F)ccc4C(F)(F)F)CC3)n[nH]c2C1.Cl>>Cl.O=C(c1n[nH]c2c1CCNC2)N1CCC(c2cc(F)ccc2C(F)(F)F)CC1,,CCOCC,ClCCl,,,val
US20140163025A1,COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccc(C6=CCOCC6)cc5)ccc(F)c43)ccc21>>COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccc(C6CCOCC6)cc5)ccc(F)c43)ccc21,[Pd],C1CCOC1,,CCN(CC)CC,,val
US20160102081A1,CC(C)(C)[Si](C)(C)OCCCn1nnc(-c2cnc(N)c(-c3cc4cc(NC(=O)Nc5ccc(Cl)c(C(F)(F)F)c5)ccc4s3)c2)n1>>Nc1ncc(-c2nnn(CCCO)n2)cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)ccc2s1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110263559A1,NNc1ccccc1.O=c1[nH]c2cc([N+](=O)[O-])ccc2c(=O)o1>>Nc1cc([N+](=O)[O-])ccc1C(=O)NNc1ccccc1,,CCO,,,,val
US20090270363A1,NC(=S)c1ccc(Br)cc1.O=C1CCCC2OC12>>OC1CCCc2nc(-c3ccc(Br)cc3)sc21,,CO,,,,val
US20160152605A1,CC(C)(C)OC(=O)N1CCCCC1=O.CSc1ccc([Mg]Br)cc1>>CSc1ccc(C(=O)CCCCNC(=O)OC(C)(C)C)cc1,,C1CCOC1,,,,val
US06316445B1,C=CC[C@H](C(=O)O)c1ccc(Cl)c(Cl)c1.O=C(Cl)C(=O)Cl>>C=CC[C@H](C(=O)Cl)c1ccc(Cl)c(Cl)c1,CN(C)C=O,ClCCl,,,,val
US20020111374A1,COc1ccc(C(=O)Cc2ccccc2)cc1.COc1ccc(C(=O)Cl)cc1>>COc1ccc(C(=O)C(C(=O)c2ccc(OC)cc2)c2ccccc2)cc1,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US20100152160A1,ClCC1CO1.Oc1cc(Cl)ccc1OCc1ccccc1>>Clc1ccc(OCc2ccccc2)c(OCC2CO2)c1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100256156A1,Br[Mg]C1CCCCC1.Cc1cc(C=O)c(C)s1>>Cc1cc(C(O)C2CCCCC2)c(C)s1,,C1CCOC1,,[Cl-].[NH4+],,val
US20100105747A1,C=C[Mg]Br.CON(C)C(=O)Cc1ccccc1C>>C=CC(=O)Cc1ccccc1C,,C1CCOC1,CCOCC,,,val
US20110039874A1,O=S(=O)([O-])CCCCCCCc1ccccc1OCc1ccccc1.O=S(Cl)Cl>>O=S(=O)(Cl)CCCCCCCc1ccccc1OCc1ccccc1,,c1ccccc1,,CN(C)C=O,,val
US20040259874A1,CCCN1CCOC(c2ccc(O)c([N+](=O)[O-])c2)C1>>CCCN1CCOC(c2ccc(O)c(N)c2)C1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20130018033A1,CCCS(=O)(=O)Nc1ccc(F)c(NC(=O)c2cc(C#CCO)cc3c(NCc4ccc(OC)cc4OC)ncnc23)c1F>>CCCS(=O)(=O)Nc1ccc(F)c(NC(=O)c2cc(C#CCO)cc3c(N)ncnc23)c1F,,O=C(O)C(F)(F)F,,,,val
US03962223,CC(C)C1=C(C(=O)[O-])N2C(=O)[C@H](NC(c3ccccc3)(c3ccccc3)c3ccccc3)[C@H]2SC1>>CC(C)C1=C(C(=O)O)N2C(=O)[C@H](N)[C@H]2SC1,,C[N+](=O)[O-],,Cl,,val
US04022897,Nc1ccc(C=CC(=O)O)cc1>>Nc1ccc(C=CCO)cc1,,CO,,[BH4-].[Na+],,val
US20090281292A1,BrCc1ccccc1.CC(=O)c1ccc(O)cc1>>c1ccc(COCc2ccccc2)cc1,,CC(C)=O,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US20130303529A1,COc1cnc2ccc(C(F)(F)C(=O)OC(C)(C)C)cc2c1>>COc1cnc2ccc(C(F)(F)C(=O)O)cc2c1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20140206663A1,C=C(c1ccc2c(c1)N1C(=NNC(=O)[C@H]1C)CO2)C1(C)CN(C(=O)OC(C)(C)C)C1>>CC(c1ccc2c(c1)N1C(=NNC(=O)[C@H]1C)CO2)C1(C)CN(C(=O)OC(C)(C)C)C1,[Pd],CO,,,,val
US04429126,CCc1ccc2nc(Cl)nc(Cl)c2c1.N>>CCc1ccc2nc(Cl)nc(N)c2c1,,CO,ClC(Cl)Cl,O,,val
US20150353499A1,COC(=O)c1cnnc2ccccc12>>OCc1cnnc2ccccc12,,[Cl-],[NH4+],CO,[BH4-].[Na+],val
US20100190825A1,CCCO[C@@H]1CC[C@@H](N2CCC(Nc3cc(Br)c(C(F)(F)F)cc3N)CC2)CC1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCO[C@@H]1CC[C@@H](N2CCC(n3c(=O)[nH]c4cc(C(F)(F)F)c(Br)cc43)CC2)CC1.Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150266867A1,CC(C)(C)OC(=O)Nc1nc(/C(=N/OC2(C(=O)OC(c3ccccc3)c3ccccc3)CC2)C(=O)N[C@@H]2C(=O)N(S(=O)(=O)O)[C@@H]2Cn2nc(CN)c(CN(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)cs1>>NCc1nn(C[C@@H]2[C@H](NC(=O)/C(=N\OC3(C(=O)O)CC3)c3csc(N)n3)C(=O)N2S(=O)(=O)O)nc1CN,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070249620A1,COC(=O)c1ccc(N)c(Cl)c1>>Nc1ccc(CO)cc1Cl,,Cc1ccccc1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20080200535A1,CC(C)CI.COC(=O)c1ccc(S)cc1>>COC(=O)c1ccc(SC(C)C)cc1,,CCOCC,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05102891,CN=C=O.Oc1ccc2c(ccn2NCCCc2ccncc2F)c1>>CNC(=O)Oc1ccc2c(ccn2NCCCc2ccncc2F)c1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20140349990A1,Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)NC2=O.Cc1nnc2c(N(C)C(=O)OC(C)(C)C)cc(Cl)nn12>>Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(N(C)C(=O)OC(C)(C)C)c3nnc(C)n3n1)C2=O,,CO,ClCCl,,,val
US20020022631A1,CCOC(=O)[C@H](Cc1cccc([N+](=O)[O-])c1)NC(C)=O>>CC(=O)N[C@H](CO)Cc1cccc([N+](=O)[O-])c1,,CCO,,[BH4-].[Na+],,val
US20110190281A1,CCN(CC)CC.COc1cccc(C2=NCCN2)c1N.N#CBr>>Br.CCN(CC)CC.COc1cccc2c1N=C(N)N1CCN=C21,,ClCCl,,,,val
US20070167443A1,COc1ccc(Cn2cc(C(=O)c3ccc(C)cn3)c(=O)c3ccccc32)cc1>>Cc1ccc(C(=O)c2c[nH]c3ccccc3c2=O)nc1,,C1COCCO1,,Cl,,val
US04505910,C=CCN.COC(=O)C(C#N)=C(SC)SC>>C=CCNC(SC)=C(C#N)C(=O)OC,,COCCOC,,,,val
US20090054407A1,COC1c2c(O)c(C=O)cc(I)c2C(=O)N1C(C)(C)c1ccccc1.CS(=O)(=O)Cl>>COC1c2c(OS(C)(=O)=O)c(C=O)cc(I)c2C(=O)N1C(C)(C)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US08080566B1,CC(C)(C)OC(=O)N1CCCC(C#N)C1.Cl>>Cl.N#CC1CCCNC1,,C1COCCO1,,,,val
US20070066610A1,CN1CCNCC1.O=C(O)c1cc(Br)c2cc[nH]c2c1>>CN1CCN(C(=O)c2cc(Br)c3cc[nH]c3c2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070287725A1,C#CCNc1c(N)c(Cl)nc2ccccc12.CCOCC(=O)Cl>>C#CCNc1c(NC(=O)COCC)c(Cl)nc2ccccc12,,ClCCl,,CCN(CC)CC,,val
US20150210630A1,CCCON=C(CN)c1ncc(Cl)cc1Cl.O=C(Cl)c1ccccc1C(F)(F)F>>CCCON=C(CNC(=O)c1ccccc1C(F)(F)F)c1ncc(Cl)cc1Cl,,ClCCl,,CCN(CC)CC,O,val
US20150031685A1,COC(=O)Cc1ccc(N)cc1.O=C(Cl)C=Cc1ccccc1>>COC(=O)Cc1ccc(NC(=O)/C=C/c2ccccc2)cc1,,ClCCl,c1ccncc1,,,val
US04797129,CNc1cc(Cl)cc(N)c1[N+](=O)[O-]>>CNc1cccc(N)c1[N+](=O)[O-],[Pd],CCN(CC)CC,,O=CO,,val
US20120316147A1,O=C(O)c1ccc(Br)c(OCC2CC2)n1.O=C1COC1>>O=C(O)c1ccc(C2(O)COC2)c(OCC2CC2)n1,,C1CCOC1,,[Li]CCCC,,val
US05196425,CC(=O)N1CCC(c2[nH]nc3cc(F)ccc23)CC1.ClCc1ccccc1>>CC(=O)N1CCC(c2c3ccc(F)cc3nn2Cc2ccccc2)CC1,,CS(C)=O,,[H-].[Na+],,val
US20150266867A1,COc1ccc(CN2C(=O)[C@@H](NC(=O)OCc3ccccc3)[C@H]2CC=O)c(OC)c1.NO>>COc1ccc(CN2C(=O)[C@@H](NC(=O)OCc3ccccc3)[C@H]2C/C=N/O)c(OC)c1,,CCO,O,Cl,O=C([O-])O.[Na+],val
US20080211391A1,C#Cc1ccc(-c2ccccn2)cc1.O=C1C(c2ccccc2)=C(c2ccccc2)C(c2ccccc2)=C1c1ccccc1.c1ccc(Oc2ccccc2)cc1>>c1ccc(-c2cc(-c3ccc(-c4ccccn4)cc3)c(-c3ccccc3)c(-c3ccccc3)c2-c2ccccc2)cc1,,c1ccc(Oc2ccccc2)cc1,,,,val
US20100210595A1,CN1C(=O)Cc2cc(NS(=O)(=O)c3cc(Cl)cc(Cl)c3)ccc21>>CN1C(=O)Cc2cc(N)ccc21,,CO,,,,val
US20090209585A1,O=C(Cl)C(=O)Cl.O=C(O)CCCC(=O)OCC(Cl)(Cl)Cl>>O=C(Cl)CCCC(=O)OCC(Cl)(Cl)Cl,,CN(C)C=O,,C1CCOC1,,val
US20030119847A1,CC(C)(C)OC(=O)NCCNc1cccc(C2(O)CC3CCC(C2)N3C(c2ccccc2Cl)c2ccccc2Cl)n1>>NCCNc1cccc(C2(O)CC3CCC(C2)N3C(c2ccccc2Cl)c2ccccc2Cl)n1,,ClCCl,,Cl,,val
US20150329548A1,C[C@@H]1CC[C@@H](Cn2cc(CCc3cccnc3)c3nc(C(N)=NO)nc(-c4cncc(Cl)c4)c32)CC1.O=C(n1ccnc1)n1ccnc1>>C[C@@H]1CC[C@@H](Cn2cc(CCc3cccnc3)c3nc(-c4noc(=O)[nH]4)nc(-c4cncc(Cl)c4)c32)CC1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20090137609A1,CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3cc(F)cc(CC(=O)OC)c3)cc2)cc1C)CC>>CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3cc(F)cc(CC(=O)O)c3)cc2)cc1C)CC,,C1CCOC1,CO,[Na+].[OH-],[Cl-].[NH4+],val
US20150051171A1,Cn1nnn(-c2cccc(Cl)c2CBr)c1=O.Oc1ccn(-c2ccc(Cl)cc2)n1>>Cn1nnn(-c2cccc(Cl)c2COc2ccn(-c3ccc(Cl)cc3)n2)c1=O,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20040048915A1,COC(=O)C(=O)c1c[nH]c2ccc(C(F)(F)F)cc12.Cn1ccc2cccc(CC(N)=O)c21>>Cn1ccc2cccc(C3=C(c4c[nH]c5ccc(C(F)(F)F)cc45)C(=O)NC3=O)c21,,CN(C)C=O,,C1CCOC1,CC(C)(C)[O-].[K+],val
US05565474,CC(=O)NC1CCN(Cc2ccccc2)C1>>CC(=O)NC1CCNC1,[Pd],CCO,,Cl,,val
US04846882,CCOCc1cc([N+](=O)[O-])c(F)cc1Cl>>CCOCc1cc(N)c(F)cc1Cl,[Pt],CC(=O)O,,[H][H],,val
US20070043031A1,Brc1cccc(CN2CCN3CCC2CC3)n1.OB(O)c1ccccc1>>c1ccc(-c2cccc(CN3CCN4CCC3CC4)n2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US20030050309A1,BrCCOCCBr.N#CCc1ccc(Cl)cc1>>N#CC1(c2ccc(Cl)cc2)CCOCC1,,CCOCC,,CS(C)=O,[H-].[Na+],val
US20060252812A1,C=O.Cc1ccc2c(c1)C(c1cc3c(cc1O)OCO3)C(=O)N2C(c1ccccc1)c1ccccc1>>Cc1ccc2c(c1)C(CO)(c1cc3c(cc1O)OCO3)C(=O)N2C(c1ccccc1)c1ccccc1,,ClCCl,,CC(C)NC(C)C,,val
US06531494B1,CCC(=O)c1ccc(OCc2ccccc2)cc1.CCOC(=O)CBr>>CCOC(=O)CC(C)C(=O)c1ccc(OCc2ccccc2)cc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20070099915A1,CCOC(=O)c1ccn(S(=O)(=O)c2ccccc2)c1C.O=C1CCC(=O)N1Br>>CCOC(=O)c1ccn(S(=O)(=O)c2ccccc2)c1CBr,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20080167303A1,Cc1ccc(N2c3ccccc3NS2(=O)=O)c(F)c1.ClC/C=C\CCl>>Cc1ccc(N2c3ccccc3N(C/C=C\CCl)S2(=O)=O)c(F)c1,,CCOCC,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05981533,CN(C)C=Nc1[nH]nc(Nc2ccc(N(C)C)cc2)c1C#N.Nc1cccc(Cl)c1>>CN(C)c1ccc(Nc2n[nH]c3ncnc(Nc4cccc(Cl)c4)c23)cc1,,O,,CN(C)C=O,Cl,val
US05175166,COC(=O)c1ccc(N)nc1.Cl>>Cl.NC1=NCC(C(=O)O)CC1,O=[Pt]=O,CCO,,,,val
US20100168105A1,CN1CCNCC1.O=C(O)C1CC12CCN(C(=O)OCc1ccccc1)CC2>>CN1CCN(C(=O)C2CC23CCN(C(=O)OCc2ccccc2)CC3)CC1,,CC#N,CCOC(C)=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100197692A1,CCOC(=O)Cn1nnc2cnc(N3CCC(Oc4cc(F)ccc4Br)CC3)nc21>>O=C(O)Cn1nnc2cnc(N3CCC(Oc4cc(F)ccc4Br)CC3)nc21,,C1CCOC1,CO,[Na+].[OH-],,val
US20110251186A1,C[Mg]Br.O=c1c2cc(Br)ccc2oc2c(F)nc(Cl)cc12>>CC1(O)c2cc(Br)ccc2Oc2c1cc(Cl)nc2F,,C1CCOC1,,O,[Cl-].[NH4+],val
US20110159019A1,CC(C)(C)OC(=O)NCCc1ccc(N)cc1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)NCCc1ccc(NS(C)(=O)=O)cc1,,ClC(Cl)Cl,,,,val
US20160038487A1,CCCc1ccc(C2CCC(=O)CC2)cc1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCCc1ccc(C2CC=C(OS(=O)(=O)C(F)(F)F)CC2)cc1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20010039286A1,CO.O=C(O)CCc1c(-c2ccc(Cl)cc2)[nH]c2ccc(Br)cc12>>COC(=O)CCc1c(-c2ccc(Cl)cc2)[nH]c2ccc(Br)cc12,,CO,,CC(=O)Cl,,val
US20090227640A1,BrC(Br)(Br)Br.OCc1cc(F)ccc1OC(F)(F)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1>>Fc1ccc(OC(F)(F)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2)c(CBr)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05707987,CC(=O)S[C@H]1C[C@@H](Cc2ccc(CNC(=O)OCc3ccc([N+](=O)[O-])cc3)c3ccccc23)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1>>O=C(NCc1ccc(C[C@@H]2C[C@H](S)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)c2ccccc12)OCc1ccc([N+](=O)[O-])cc1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20030096788A1,CC(=O)O[C@@H]1[C@@H](c2cc(C(C)(C)C)no2)O[C@@H](n2cnc3c(NC4CCN(C(=O)OC(C)(C)C)CC4)ncnc32)[C@@H]1OC(C)=O>>CC(=O)O[C@@H]1[C@@H](c2cc(C(C)(C)C)no2)O[C@@H](n2cnc3c(NC4CCNCC4)ncnc32)[C@@H]1OC(C)=O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20070275968A1,C1COCCN1.CC1(C)OB(c2ccc(CC(=O)O)cc2)OC1(C)C.CCN=C=NCCCN(C)C>>CC1(C)OB(c2ccc(CC(=O)NC3CCOCC3)cc2)OC1(C)C,,ClCCl,,Cl,O,val
US20120208796A1,CC(C)NC(=O)CNC(=O)c1cc(N2CCN3CCC2CC3)ccc1[N+](=O)[O-]>>CC(C)NC(=O)CNC(=O)c1cc(N2CCN3CCC2CC3)ccc1N,[Pd],CO,,[H][H],,val
US20040167121A1,C1CCNCC1.NC(=O)c1cc(F)ccc1[N+](=O)[O-]>>NC(=O)c1cc(N2CCCCC2)ccc1[N+](=O)[O-],,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20100056813A1,Fc1ccc2c(c1)CC[C@@H]([C@H]1CO1)O2.NCc1ccccc1>>O[C@H](C=NCc1ccccc1)[C@@H]1CCc2cc(F)ccc2O1,,CO,,,,val
US05668176,CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2.NS(N)(=O)=O>>CCCc1cc(C(=O)NS(N)(=O)=O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2,,C1CCOC1,,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US04713387,CC(COCCO)C(O)c1ccc(Cc2cccnc2)cc1.Cl>>CC(COCCO)C(Cl)c1ccc(Cc2cccnc2)cc1,,CCO,CCOC(C)=O,O,O=C([O-])O.[Na+],val
US20040097574A1,CC(N)Cc1c[nH]c2ccccc12.Cc1cc(C)c(S(=O)(=O)Cl)c(C)c1>>Cc1cc(C)c(S(=O)(=O)NC(C)Cc2c[nH]c3ccccc23)c(C)c1,,ClCCl,,CCN(CC)CC,,val
US20110112146A1,COC(=O)CC(=O)c1ccccc1O.O=Cc1cccc(Cl)c1>>COC(=O)C1C(=O)c2ccccc2OC1c1cccc(Cl)c1,,CC(C)O,,C1CCNCC1,CC(=O)O,val
US20040092737A1,COC(=O)c1ccc2c(c1)Nc1nccnc1S2.COCCl>>COCN1c2cc(C(=O)OC)ccc2Sc2nccnc21,,CN(C)C=O,,[H-].[Na+],,val
US20120015975A1,CC(C)(C)Nc1ccc(C(F)(F)F)cc1[N+](=O)[O-]>>CC(C)(C)Nc1ccc(C(F)(F)F)cc1N,[Pd],CCOC(C)=O,,,,val
US20120316214A1,CCOC(CCCl)OCC.NC(=O)c1ccc(O)cc1>>CCOC(CCOc1ccc(C(N)=O)cc1)OCC,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100087424A1,COc1ccc2ncc(F)c(SC(C)(C)C)c2n1>>COc1ccc2ncc(F)c(S)c2n1,,Cl,,,,val
US20070179196A1,C=C[Sn](CCCC)(CCCC)CCCC.COc1c2c(c(Br)n(C)c1=O)CCN(Cc1ccc(F)c(Cl)c1)C2=O>>CCc1c2c(c(OC)c(=O)n1C)C(=O)N(Cc1ccc(F)c(Cl)c1)CC2,[Pt],C1CCOC1,CCO,[H][H],,val
US04551460,CC(=O)NCCCCCCCc1cccnc1>>NCCCCCCCc1cccnc1,,Cl,,[Na+].[OH-],,val
US20150239895A1,CC(=O)c1cn(CC(=O)OC(C)(C)C)c2ccc(Br)cc12.CC1(C)OB(c2ccnnc2)OC1(C)C>>CC(=O)c1cn(CC(=O)OC(C)(C)C)c2ccc(-c3ccnnc3)cc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110243865A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.NCCO>>NCCOC(c1ccccc1)(c1ccccc1)c1ccccc1,,c1ccncc1,,Cl,O,val
US04000278,COC(=O)C1CCc2cc3ccccc3nc21.N>>NC(=O)C1CCc2cc3ccccc3nc21,,CO,,,,val
US20110105329A1,COc1cc2cccnc2c(OC)c1-c1ccccc1C>>Cc1ccccc1-c1c(O)cc2cccnc2c1O,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20060173019A1,Cc1cc(S(=O)(=O)Cl)ccc1Cl.Nc1cc(Cl)cnc1Br>>Cc1cc(S(=O)(=O)Nc2cc(Cl)cnc2Br)ccc1Cl,,c1ccncc1,,,,val
US20070244095A1,CCc1cc2c(cc1C(F)(F)F)N(C(=O)OC(C)(C)C)CCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1>>CCc1cc2c(cc1C(F)(F)F)NCCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150291597A1,CCCN.CNOC.Clc1nc(Cl)nc(Cl)n1>>CCCNc1nc(Cl)nc(N(C)OC)n1,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20030028022A1,BrCc1ccccc1.NC(=S)c1ccccc1>>Br.N=C(SCc1ccccc1)c1ccccc1,,ClCCl,,,,val
US20130150343A1,Fc1ccc2nnc(Cl)n2c1.OC[C@H]1CCNC1>>OC[C@H]1CCN(c2nnc3ccc(F)cn23)C1,,CC(=O)N(C)C,,,,val
US03959478,O=C(Cl)c1c(F)cccc1F.O=c1[nH]c(=O)n(-c2cccc(Cl)c2)o1>>O=C(c1c(F)cccc1F)n1c(=O)on(-c2cccc(Cl)c2)c1=O,,Cc1ccccc1,,CCN(CC)CC,,val
US20040121316A1,C(=NC1CCCCC1)=NC1CCCCC1.CCOC(=O)C(O)CC.O=[PH]([O-])Oc1ccccc1.c1ccncc1>>O=[PH](OCc1ccccc1)OCc1ccccc1,,CCOC(C)=O,,,,val
US20050096380A1,CCOC(=O)/C=C(C)/C=C/C(F)=C(/C)c1cc2c(cc1OCC)C(C)(C)CC=C2>>CCOc1cc2c(cc1/C(C)=C(F)\C=C\C(C)=C\C(=O)O)C=CCC2(C)C,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20090117125A1,O=C(Cl)c1ccccc1.O=C(O)C1Cc2ccccc2N1>>O=C(O)C1Cc2ccccc2N1C(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US05124478,COC(=O)CCc1ccc(OC)cc1OC.COc1ccc(C(=O)Cl)cc1>>COC(=O)CCc1cc(C(=O)c2ccc(OC)cc2)c(OC)cc1OC,,ClCCCl,ClCCl,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20010027194A1,COc1cc(C(=O)O)cc(OC)c1OCc1ccccc1.O=C(n1ccnc1)n1ccnc1.[NH4+]>>NC(=O)c1ccccc1,,C1CCOC1,CCOC(C)=O,Cl,,val
US20020025959A1,CCOC(=O)c1cnc2c(C=O)cc(CN3CCOCC3)cc2c1O.NCc1ccccc1>>CCOC(=O)c1cnc2c(CNCc3ccccc3)cc(CN3CCOCC3)cc2c1O,,C1CCOC1,CCO,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150218096A1,NNC(=O)c1ccc2c(I)nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1.O=C(n1ccnc1)n1ccnc1>>O=C(c1c(Cl)cccc1C(F)(F)F)n1nc(I)c2ccc(-c3n[nH]c(=O)o3)cc21,,C1CCOC1,O,CCN(CC)CC,,val
US20120004262A1,Cl.FC(F)(F)c1ccc(CN[C@@H]2C[C@H]2c2ccccc2)cc1>>Cl.FC(F)(F)c1ccc(CN[C@@H]2C[C@H]2c2ccccc2)cc1,,CCOCC,,,,val
US20040009966A1,COC(=O)CN1CC=CCC(NC(=O)c2nccc3ccccc23)C1=O>>O=C(O)CN1CC=CCC(NC(=O)c2nccc3ccccc23)C1=O,,C1CCOC1,O,[Li+].[OH-],,val
US06107458,CC(C)OB(OC(C)C)OC(C)C.CCCCOc1ccc(-c2ccc(Br)cc2)cc1>>CCCCOc1ccc(-c2ccc(B(O)O)cc2)cc1,,C1CCOC1,CCCCCC,Cl,[Li]CCCC,val
US20130065861A1,CCCCCCCCCCCCCCCC(=O)Cl.CCCCCCCCCCNC(=O)OC[C@H](CSC[C@H](N)C(=O)OC(C)(C)C)OC(=O)NCCCCCCCCCC>>CCCCCCCCCCCCCCCC(=O)N[C@@H](CSC[C@@H](COC(=O)NCCCCCCCCCC)OC(=O)NCCCCCCCCCC)C(=O)OC(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080027041A1,CC(=O)c1cc(F)c(OCCCCl)c(F)c1.NN.O=CC(=O)O>>O=c1ccc(-c2cc(F)c(OCCCCl)c(F)c2)n[nH]1,,CC(=O)O,,O,O,val
US20100216762A1,O=C(Cc1cccc(C(F)(F)F)c1)c1ccc(C2OCCO2)cc1>>O=Cc1ccc(C(=O)Cc2cccc(C(F)(F)F)c2)cc1,,C1CCOC1,,CCOC(C)=O,Cl,val
US06191124B1,BrCCc1ccccc1.O=Cc1cnc2sc3ccccc3n12>>OC(CCc1ccccc1)c1cnc2sc3ccccc3n12,,C1CCOC1,,II,[Mg],val
US20050277652A1,Nc1cc(Oc2ccc([N+](=O)[O-])cc2F)ccn1.O=C(Cl)Oc1ccccc1>>O=C(Nc1cc(Oc2ccc([N+](=O)[O-])cc2F)ccn1)Oc1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20140163012A1,Cl.O=c1cc(OCc2ccc(C(F)(F)F)nc2)ccn1-c1ccc2c3c(oc2c1)CCNC3>>Cl.O=c1cc(OCc2ccc(C(F)(F)F)nc2)ccn1-c1ccc2c3c(oc2c1)CCNC3,,CO,,CCOCC,,val
US04352752,COC(=O)C(C(C)C)N1C(=O)C(N)C1c1ccccc1>>CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)O,[Pd],CCO,,,,val
US20040024010A1,C1COCCN1.O=C(O)CCc1c(C=C2C(=O)Nc3ccccc32)[nH]c2c1CCCC2>>O=C1Nc2ccccc2C1=Cc1[nH]c2c(c1CCC(=O)N1CCOCC1)CCCC2,,CN(C)C=O,,O,O=C(n1ccnc1)n1ccnc1,val
US20160168139A1,COC(=O)c1cc([N+](=O)[O-])ccc1Br.COc1ccc(COc2cc(N3CCOCC3)cc(-c3ccccc3N)n2)cc1>>COC(=O)c1cc([N+](=O)[O-])ccc1Nc1ccccc1-c1cc(N2CCOCC2)cc(OCc2ccc(OC)cc2)n1,[Cu]I,CN1CCCC1=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US04745224,CC(C)CCP(=S)(CCC(C)C)CCC(C)C.O=S(=O)(O)c1ccc(Cl)cc1>>CC(C)CCP(=O)(CCC(C)C)CCC(C)C,,Clc1ccccc1,,,,val
US20080021010A1,CN1CCCCC1C1(CN)CN(C(=O)OC(C)(C)C)C1.O=C(Cl)c1c(F)ccc(F)c1Cl>>CN1CCCCC1C1(CNC(=O)c2c(F)ccc(F)c2Cl)CN(C(=O)OC(C)(C)C)C1,,ClCCl,,CCN(CC)CC,,val
US03941826,CC(C)c1cc(Br)c(C(C)C)cc1S.COS(=O)(=O)OC>>CSc1cc(C(C)C)c(Br)cc1C(C)C,,O,,[Na+].[OH-],,val
US20040152690A1,CC(=O)N(C)Cc1cnc(N2CCN[C@H](C)C2)c(Cl)c1.FC(F)(F)c1ccc2nc(Cl)[nH]c2c1>>CC(=O)N(C)Cc1cnc(N2CCN(c3nc4cc(C(F)(F)F)ccc4[nH]3)[C@H](C)C2)c(Cl)c1,,CCO,,,,val
US20130158075A1,Nc1ccc(-c2cnc(CNS(=O)(=O)C(F)(F)F)s2)cc1.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(Nc1ccc(-c2cnc(CNS(=O)(=O)C(F)(F)F)s2)cc1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20090281087A1,CC(C)(C)C=O.CN1CCNCC1.Clc1ccc(N2CCNC(Br)C2)cc1>>CN1CCN(CC(C)(C)C(=O)N2CCN(c3ccc(Cl)cc3)CC2)CC1,,CN1CCCC1=O,,,,val
US20120094958A1,O=c1ccc2cc([N+](=O)[O-])cc(-c3cccc4ccccc34)c2[nH]1>>Nc1cc(-c2cccc3ccccc23)c2[nH]c(=O)ccc2c1,[Ni],C1CCOC1,CO,,,val
US20020094983A1,CC1Nc2ccc(Br)cc2C(C)(C)O1.OB(O)c1ccc(F)c(Cl)c1>>CC1Nc2ccc(-c3ccc(F)c(Cl)c3)cc2C(C)(C)O1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20150344481A1,Nc1cn2nc(-c3c(-c4ccc(F)cc4)ncn3CCN3CCOCC3)ccc2n1.O=C(O)c1ccncc1>>O=C(Nc1cn2nc(-c3c(-c4ccc(F)cc4)ncn3CCN3CCOCC3)ccc2n1)c1ccncc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130274243A1,CC(C)(C)OC(=O)N[C@H](C(=O)O)C(C)(C)O.CC(C)(C)c1ccc(N)c(N)c1>>CC(C)(C)c1ccc2[nH]c([C@@H](N)C(C)(C)O)nc2c1,,C1COCCO1,CCOC(C)=O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US04486438,COCc1nc2c(C(F)(F)F)cccc2c(O)c1C(=O)Nc1nccs1>>O=C(Nc1nccs1)c1c(CO)nc2c(C(F)(F)F)cccc2c1O,,ClCCl,,BrB(Br)Br,O,val
US05889026,CCOC(=O)N1CCC(O)(Cc2ccc(C)cc2)CC1>>Cc1ccc(CC2(O)CCNCC2)cc1,,CCO,O,[Na+].[OH-],,val
US20040106667A1,CS(=O)(=O)c1ccc(F)cc1S(=O)(=O)Cl.CS(=O)(=O)c1ccc(F)cc1S(=O)(=O)Nc1ccc2[nH]nc(-c3ccccc3)c2c1.Nc1ccc2[nH]nc(-c3ccccc3)c2c1.c1ccncc1>>CC(C)OC(C)C.CS(=O)(=O)c1ccc(F)cc1S(=O)(=O)Nc1ccc2[nH]nc(-c3ccccc3)c2c1,,c1ccncc1,,,,val
US20110183985A1,C#Cc1c(Cl)cc([C@@H](C)O)c(-c2cccc(F)c2)c1/N=N/N1CCCC1>>C[C@@H](O)c1cc(Cl)c2ccnnc2c1-c1cccc(F)c1,,Clc1ccccc1Cl,,,,val
US20160009744A1,Cc1nc(CO)c(CCO)s1>>Cc1nc2c(s1)CCOC2=O,O=[Mn]=O,,,ClCCl,,val
US20060178532A1,CC(C)N(NC(=O)c1ccccc1)C(=O)CSc1ccccc1Br.COc1ccc(B(O)O)cc1>>COc1ccc(-c2ccccc2SCC(=O)N(NC(=O)c2ccccc2)C(C)C)cc1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20110034436A1,CC(=O)OC(C)=O.CCOC(=O)CC(=O)c1cc(F)c(F)c(F)c1F.NC1(CO)CCC1>>CCOC(=O)C(=CNC1(CO)CCC1)C(=O)c1cc(F)c(F)c(F)c1F,,Cc1ccccc1,,CCN(CC)CC,,val
US20070208054A1,CN(CCc1ccc(C(Nc2cccc(C(N)=O)c2)C(=O)O)cc1)C(=O)OCc1ccccc1>>CNCCc1ccc(C(Nc2cccc(C(N)=O)c2)C(=O)O)cc1,[Pd],,,,,val
US20130059834A1,Cn1nc(-c2cnc3c(n2)c(C(=O)NC2CCCC(O)C2)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21>>Cn1nc(-c2cnc3[nH]cc(C(=O)NC4CCCC(O)C4)c3n2)c2ccc(Cl)cc21,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US20030018193A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C[C@H](N)c1ccc(O)cc1>>CCOC(=O)C[C@H](NC(=O)OC(C)(C)C)c1ccc(O)cc1,,C1CCOC1,,,,val
US20080070935A1,CN(C)CCO.Cc1cn(-c2ccc3c(N)ncnc3c2F)c2c1C(=O)CC(C)(C)C2>>Cc1cn(-c2ccc3c(N)ncnc3c2OCCN(C)C)c2c1C(=O)CC(C)(C)C2,,CN(C)C=O,,[H-].[Na+],,val
US20050222175A1,COC(=O)c1cccc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)c1>>O=C(O)c1cccc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)c1,,CO,O,[Li]O,,val
US20100075944A1,C1CCOC1.CCOC(C)=O.Nc1cc(Oc2ccc(NC(=O)OCc3ccccc3)cc2F)ccn1.O=C(Cl)Oc1ccccc1.O=C([O-])O>>O=C(Nc1ccc(Oc2ccnc(N(C(=O)Oc3ccccc3)C(=O)Oc3ccccc3)c2)c(F)c1)OCc1ccccc1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20090143581A1,O=C/C=C/c1ccccc1.ONc1ccccc1>>[O-][N+](=C/C=C/c1ccccc1)c1ccccc1,,CCO,,,,val
US20130190325A1,COc1cc(OC)c(C=O)c(OC)c1.COc1ncc(CS(=O)CC(=O)O)cc1[N+](=O)[O-]>>COc1cc(OC)c(/C=C/S(=O)Cc2cnc(OC)c([N+](=O)[O-])c2)c(OC)c1,C1CCNCC1,c1ccncc1,,,,val
US20150284394A1,CC(C)(C)OC(=O)CN.O=Cc1c(Cl)ncnc1Cl>>CC(C)(C)OC(=O)C1Nc2ncnc(Cl)c2C1O,,CCO,,CCN(CC)CC,,val
US20070010511A1,CN.Cc1ccc(S(=O)(=O)O[C@H]2CCN(Cc3ccccc3)C2)cc1>>NC[C@H]1CCN(Cc2ccccc2)C1,,CCO,,,,val
US20080262042A1,CCOC(C)=O.CCOC(C)=O.CN(Cc1cn(S(=O)(=O)c2ccc(C#N)o2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C>>CNCc1cn(S(=O)(=O)c2ccc(C#N)o2)c(-c2cccnc2F)c1F.O=C(O)/C=C/C(=O)O,,CC(C)O,,Cl,,val
US20100261902A1,ICCCI.O=c1[nH]cccc1OCc1ccccc1>>O=c1c(OCc2ccccc2)cccn1CCCI,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20110319406A1,C1COCCN1.N#Cc1cc(CBr)cc([N+](=O)[O-])c1>>N#Cc1cc(CN2CCOCC2)cc([N+](=O)[O-])c1,,ClCCl,,CCN(CC)CC,,val
US20080115247A1,CC#N.CC(O)c1ccc(O)cc1.CCN(CC)CC.Cc1ccccc1.OC(=S)c1ccccc1>>CCCC(C)C.Oc1ccc(CCOC(=S)c2ccccc2)cc1,,CC#N,Cc1ccccc1,O=S(Cl)Cl,O=C([O-])O.[Na+],val
US20100120806A1,CCN(CC)CC.O=C(Cl)C1(C(=O)Nc2ccc(F)cc2)CC1>>NC(=O)C1(C(N)=O)CC1,,C1CCOC1,,,,val
US20140010762A1,NCCCOc1ccc(CO)cc1.O=[N+]([O-])c1ccc(Cl)c2nonc12>>O=[N+]([O-])c1ccc(NCCCOc2ccc(CO)cc2)c2nonc12,,CCO,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20160068532A1,C=Cc1cc2c(-c3ccnc(C)c3)nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c2cc1[N+](=O)[O-].O=[O+][O-]>>Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc([N+](=O)[O-])c(C=O)cc23)ccn1,,CO,ClCCl,,,val
US20120101083A1,COC(=O)CBr.Cc1c(-c2noc(-c3ccc(OC(C)C)c(Cl)c3)n2)ccc2c1CCNC2>>COC(=O)CN1CCc2c(ccc(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)c2C)C1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US05760035,CCC(=O)Cl.NCC1CCN(CCOc2ccccc2)CC1>>CCC(=O)NCC1CCN(CCOc2ccccc2)CC1,,CCN(CC)CC,ClCCl,,,val
US20150329538A1,C[C@H]1NC(=O)c2cc(B3OC(C)(C)C(C)(C)O3)[nH]c21.Cn1c(NC2(C)CCC2)nc2c(Br)c(F)ccc2c1=O>>C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C)c(NC5(C)CCC5)nc34)[nH]c21,,C1COCCO1,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20110086854A1,CC(C)(C)CC1CNC(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.O=C(O)c1ccc(C(=O)O)cc1>>CC(C)(C)C[C@@H]1CN(C(=O)c2ccc(C(=O)O)cc2)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05348944,O=C(O)[C@@H]1CCC(O)CN1C(=O)OCc1ccccc1>>O=C1CC[C@@H](C(=O)O)N(C(=O)OCc2ccccc2)C1,,CC(C)=O,,O=S(=O)(O)O,O=[Cr](=O)=O,val
US20060041137A1,CCCC1=NNC(=O)/C1=C1/C=C(Sc2ccc(N)cc2)c2ccccc2N1.O=C(Cl)c1cccs1>>CCCC1=NNC(=O)/C1=C1/C=C(Sc2ccc(NC(=O)c3cccs3)cc2)c2ccccc2N1,,C1CCOC1,,,,val
US20120035196A1,CCOC(=O)C=C1c2ccccc2-c2cc(OCc3cccc(-c4c(C)cc(OCCOC(C)=O)cc4C)c3C)ccc21>>CCOC(=O)CC1c2ccccc2-c2cc(OCc3cccc(-c4c(C)cc(OCCOC(C)=O)cc4C)c3C)ccc21,[Pd],CCO,,,,val
US06737425B1,CCC(CN1CCN(Cc2ccccc2)CC1)Oc1ccc(F)cc1>>CCC(CN1CCNCC1)Oc1ccc(F)cc1,,CC(Cl)Cl,,CC(Cl)OC(=O)Cl,,val
US03935314,O=[N+]([O-])c1ccc2nc(NC3=NCCN3)[nH]c2c1>>Nc1ccc2nc(NC3=NCCN3)[nH]c2c1,[Pd],CN(C)C=O,,,,val
US20120065064A1,COC1=C(c2c(C)cc(C)cc2C)C(=O)C(C(O)c2ccoc2)C1>>Cc1cc(C)c(C2C(=O)C/C(=C\c3ccoc3)C2=O)c(C)c1,,CC(C)=O,,Cl,,val
US20150152047A1,CCOC(=O)c1cc(OC(F)(F)F)c(CN2CCN(C(=O)OC(C)(C)C)CC2)cc1[N+](=O)[O-]>>CCOC(=O)c1cc(OC(F)(F)F)c(CN2CCN(C(=O)OC(C)(C)C)CC2)cc1N,[Fe],CCOC(C)=O,,[Cl-].[NH4+],,val
US04767882,Cc1ccc(C(C)(C)C[C@H]2CC(=O)OC2(C)C)cc1>>Cc1ccc2c(c1)C(C)(C)[C@H](CC(=O)O)CC2(C)C,,Cc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20050245743A1,CC(C)(C)OC(=O)N1CCC(c2ccc(F)c(NC(=O)CCCCC(=O)c3ccccc3)c2)CC1>>O=C(CCCCC(=O)c1ccccc1)Nc1cc(C2CCNCC2)ccc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US04374137,CCOC(=O)Cl.CN1Cc2ccccc2C2(Cc3ccccc3O2)C1>>CCOC(=O)N1Cc2ccccc2C2(Cc3ccccc3O2)C1,,c1ccccc1,,,,val
US08124196B2,CCCC12CCC(O)(CC1)C(F)C2(F)F.CCOc1ccc(CBr)c(F)c1F>>CCCC12CCC(OCc3ccc(OCC)c(F)c3F)(CC1)C(F)C2(F)F,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20160221945A1,COc1nn(-c2cnc(C(F)(F)F)nc2)cc1C#N.Cl>>COc1nn(-c2cnc(C(F)(F)F)nc2)cc1CN.Cl,[Pd],CO,,,,val
US20070037796A1,Brc1ccc2ccncc2c1.CC(C)(C)OC(=O)NCCN.O=[SH](=O)OCl.c1ccncc1>>NCCNS(=O)(=O)c1cc(-c2ccccc2)cc2cnccc12,,ClCCl,,O=C([O-])O.[Na+],,val
US20130210844A1,CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)O)c1.Nc1cccc2c(Oc3cccc(C(F)(F)F)c3)ncnc12>>CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)Nc2cccc3c(Oc4cccc(C(F)(F)F)c4)ncnc23)c1,CN(C)C=O,ClCCl,,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20160083365A1,C[C@H](N)c1cc2cc(Cl)ccc2[nH]c1=O.Cc1nnnn1-c1ccnc(Cl)n1>>Cc1nnnn1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1,,CS(C)=O,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20090099177A1,Nc1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)n1.O=C(Cl)Cc1ccccc1>>O=C(Cc1ccccc1)Nc1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)n1,,ClCCl,,,,val
US04638070,CC(Br)C(O)c1ccc2c(c1)CCS2.NCCCCc1ccccc1>>CC(NCCCCc1ccccc1)C(O)c1ccc2c(c1)CCS2,,CCOCC,,CCO,,val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)O)cc1.Nc1ccc(-c2nc(C(F)(F)F)n[nH]2)cc1>>Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nc(C(F)(F)F)n[nH]3)cc2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05750545,CN=C=S.Nc1nc[nH]n1>>CNC(=S)n1ncnc1N,,CN(C)C=O,,,,val
US04203932,CC(=O)Cl.CCOP(=O)(NN)OCC>>CCOP(=O)(NNC(C)=O)OCC,,ClCCl,,CCN(CC)CC,,val
US20070275897A1,C[C@H]1C[C@@H](C(=O)NCC(=O)OCc2ccccc2)N(C(=O)[C@@H]2C[C@@H](C)CN2C(=O)OCC2c3ccccc3-c3ccccc32)C1>>C[C@H]1C[C@@H](C(=O)NCC(=O)O)N(C(=O)[C@@H]2C[C@@H](C)CN2C(=O)OCC2c3ccccc3-c3ccccc32)C1,[Pd],CO,,,,val
US06391887B1,O=C1CCC(=O)N1Br.O=C1Nc2ccccc2C2CCCC12>>O=C1Nc2ccc(Br)cc2C2CCCC12,,CN(C)C=O,O,,,val
US20110150834A1,CC(C)=O.O=Cc1ccc(F)cc1F>>CC(=O)/C=C/c1ccc(F)cc1F,,O,,[Na+].[OH-],,val
US20070049581A1,CCO.CN1CCN(C(=O)OCCCc2ccccc2)[C@H](C(=O)[O-])C1>>CCOC(=O)[C@@H]1CN(C)CCN1,[Pd],,,[H][H],,val
US05607977,NC(=O)c1c(F)cccc1F.O=C=Nc1cc(Cl)c(Cl)c(Cl)c1>>O=C(NC(=O)c1c(F)cccc1F)Nc1cc(Cl)c(Cl)c(Cl)c1,,Cc1ccccc1,,,,val
US20040121964A1,C[C@H]1CC[C@@H](C#N)N1C(=O)CCl.NC1CCCC1>>C[C@H]1CC[C@@H](C#N)N1C(=O)CNC1CCCC1,,CC#N,,,,val
US20030060472A1,O=C(CCl)c1cc(O)c(O)c([N+](=O)[O-])c1.c1ccncc1>>CC=O.O=[N+]([O-])c1cc(N2C=CC=C[CH3+]2)cc(O)c1O.[Cl-],,CN(C)C=O,,,,val
US20080167301A1,CCOc1cc(C2CC(OC(C)=O)CCC2N)ccc1OC.COc1ccc(C(=O)O)c(OC)n1>>CCOc1cc([C@H]2C[C@H](OC(C)=O)CCC2NC(=O)c2ccc(OC)nc2OC)ccc1OC,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20160194315A1,COC(=O)c1ccnc2cc(C(O)c3ccccc3)[nH]c12>>O=C(O)c1ccnc2cc(C(O)c3ccccc3)[nH]c12,,CC#N,O,,,val
US20060148858A1,CC(C)c1nn(-c2ccc(Cl)cn2)cc1CCCO.CCc1cccc(CC(=O)OC)c1O>>CCc1cccc(CC(=O)OC)c1OCCCc1cn(-c2ccc(Cl)cn2)nc1C(C)C,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20030027816A1,CCOC(C)=O.Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1.O>>Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1.O.O,,CCOC(C)=O,Cc1ccccc1,,,val
US20110312953A1,COC(=O)c1sc(Cn2nnc(C(F)(F)F)n2)nc1-c1ccccc1Cl>>O=C(O)c1sc(Cn2nnc(C(F)(F)F)n2)nc1-c1ccccc1Cl,,C1COCCO1,,O,[Na+].[OH-],val
US05602277,CCOC(=O)c1ccc(NC(=O)C(C)C)c([N+](=O)[O-])c1>>CCOC(=O)c1ccc(NC(=O)C(C)C)c(N)c1,O=[Pt],CCO,,CCCCCC,CCOC(C)=O,val
US20130053366A1,COc1ccc(C2(C)CO2)cn1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>COc1ccc(C(C)(O)Cn2c3c(c4cc(C)ccc42)CN(C)CC3)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20020025960A1,Nc1sccc1S(=O)(=O)CC(=O)NCc1ccc(Cl)cc1.O=N[O-]>>O=C(NCc1ccc(Cl)cc1)C1=NNc2sccc2S1(=O)=O,,CC(=O)O,,O,,val
US20060235004A1,CC(C)(C)c1nc(N2CCNCC2)cc(C(F)(F)F)n1.Cc1cn(CCCCCl)c(=O)nc1O>>Cc1cn(CCCC[NH+]2CCN(c3cc(C(F)(F)F)nc(C(C)(C)C)n3)CC2)c(=O)nc1O.[Cl-],,CN(C)C=O,,CCN(CC)CC,CCOC(C)=O,val
US04290954,CN1CCCC1=O.O=c1c2c(oc3ccc(Br)cc13)CCCC2>>N#Cc1ccc2oc3c(c(=O)c2c1)CCCC3,,O,,Cl,,val
US06956053B2,CN(C)C=C(C(=O)COC12CC3CC(CC(C3)C1)C2)C(=O)OCc1ccccc1.Cc1ccccc1NN>>Cc1ccccc1-n1cc(C(=O)OCc2ccccc2)c(COC23CC4CC(CC(C4)C2)C3)n1,,CC#N,,CCN(CC)CC,Cl,val
US20100063054A1,CCOC(=O)C(C)C(=O)OCC.Clc1ccc(Cl)nn1>>CCOC(=O)C(C)(C(=O)OCC)c1ccc(Cl)nn1,,C1COCCO1,,[H-].[Na+],,val
US20030114666A1,C[C@@H](c1ccccc1)N1CC[C@@H](C2(N(Cc3ccccc3)Cc3ccccc3)CC2)C1>>NC1([C@@H]2CCNC2)CC1,[Pd],CC(=O)O,,[H][H],,val
US20150305332A1,CO.O=C(O)c1csc2ccccc12>>COC(=O)c1csc2ccccc12,,CO,,O=C(Cl)C(=O)Cl,,val
US05559230,CCOC(=O)COC1CCCN(C(=O)c2ccc(NC(=O)c3ccc(Cl)cc3Cl)cc2)c2ccccc21>>O=C(O)COC1CCCN(C(=O)c2ccc(NC(=O)c3ccc(Cl)cc3Cl)cc2)c2ccccc21,,CCO,,[Na+].[OH-],,val
US20160194316A1,CO.Cn1[nH]c(=O)c(C#N)c1N1CCCCC1>>COc1nn(C)c(N2CCCCC2)c1C#N,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020028836A1,CC(C)(C)OC[C@H](NC(=O)OCc1ccccc1)C(N)=O.Cl>>CC(C)(C)OC[C@H](N)C(N)=O.Cl,[Pd],CO,,[H][H],,val
US20130137691A1,COC(=O)[C@H]1CC[C@@H](Oc2ccc(C(=O)O)cc2)CC1.N>>COC(=O)[C@@H]1CC[C@H](Oc2ccc(C(N)=O)cc2)CC1,,C1COCCO1,,ClCCCl,On1nnc2ccccc21,val
US05686482,COC(=O)c1cc(N)c(OC)cc1OC.O=CO>>COC(=O)c1cc(NC=O)c(OC)cc1OC,,C1CCOC1,,CC(=O)OC(C)=O,,val
US20150368256A1,COc1ccc(-c2c(C#N)c(C3CCCCC3)nc3c2CCCCC3)cn1>>N#Cc1c(C2CCCCC2)nc2c(c1-c1ccc(=O)[nH]c1)CCCCC2,,O,,C1COCCO1,Cl,val
US20050250815A1,CC(C)(C)OC(=O)N1CCCC1C(=O)O.Nc1ccc(Br)cc1C(F)(F)F>>CC(C)(C)OC(=O)N1CCCC1C(=O)Nc1ccc(Br)cc1C(F)(F)F,,CCOCC,ClCCl,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20070254937A1,CC(C)(C)OC(=O)n1nc(-c2cc3cc(O[Si](C)(C)C(C)(C)C)ccc3n2C(=O)OC(C)(C)C)c2sccc21>>CC(C)(C)OC(=O)n1nc(-c2cc3cc(O)ccc3n2C(=O)OC(C)(C)C)c2sccc21,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130029954A1,C=C(C)[C@@H]1CC[C@]2(C=O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC(C)(C)C)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.NO>>C=C(C)[C@@H]1CC[C@]2(/C=N/O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC(C)(C)C)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060258721A1,CI.CN1CC=C(c2c[nH]c3ccc(NC(=S)NC(=O)c4ccccc4)cc23)CC1>>CSC(=N)Nc1ccc2[nH]cc(C3=CCN(C)CC3)c2c1,,CC(C)=O,,,,val
US20080146523A1,CC(C)C(=Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)c1ccccc1>>CC(C)C(Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)c1ccccc1,[Pd],CO,,ClCCl,,val
US08729274B2,C/C=C\c1cccc2c1CC[C@]1(C)CN(Cc3ccccc3)C[C@H]21.CC(Cl)OC(=O)Cl>>C/C=C\c1cccc2c1CC[C@]1(C)CNC[C@H]21.Cl,,Cc1ccccc1,,CO,,val
US20130245042A1,Fc1ccc([C@H]2C[C@@H]2CNc2ccnc(Cl)c2C(F)(F)F)cc1.NN>>NNc1nccc(NC[C@H]2C[C@@H]2c2ccc(F)cc2)c1C(F)(F)F,,C1COCCO1,CCOC(C)=O,O,,val
US05292719,CC(=O)Cl.COc1cccc(OC)c1>>COc1ccc(C(C)=O)c(OC)c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05418237,NC(=O)Nc1ccc2[nH]cc(CCCCCl)c2c1.c1ccc(N2CCNCC2)cc1>>Cl.NC(=O)Nc1ccc2[nH]cc(CCCCN3CCN(c4ccccc4)CC3)c2c1,,CC#N,,,,val
US20010001101A1,CCOC=C(C(=O)OCC)C(=O)OCC.CN(Cc1ccccc1)C(=O)c1cnc2c(N)cc(F)cc2c1>>CCOC(=O)C1C=Nc2c(c(F)cc3cc(C(=O)N(C)Cc4ccccc4)cnc23)C1=O,,c1ccc(Oc2ccccc2)cc1,,,,val
US03994940,CN(C)CCc1nnc(CN2C(=O)c3ccccc3C2=O)n1-c1ccccc1C(=O)c1ccccc1Cl>>CN(C)CCc1nnc2n1-c1ccccc1C(c1ccccc1Cl)=NC2,,CCO,,NN,O,val
US20110312969A1,BrCc1ccc(Br)cc1.CCOC(=O)c1cccc(OCCCn2c(=N)[nH]c3ccccc32)c1>>Br.CCOC(=O)c1cccc(OCCCn2c(=N)n(Cc3ccc(Br)cc3)c3ccccc32)c1,,CCC(C)=O,,,,val
US20050131013A1,OCCBr.Oc1c(Br)cc(Br)c2cccnc12>>OCCc1c(Br)cc(Br)c2cccnc12,,O,,CN(C)C=O,,val
US06392104B1,CN(C)C=O.OC12CC3CC(C1)CC(O)(C3)C2>>CNC(=O)OC12CC3CC(CC(O)(C3)C1)C2,c1ccncc1,,,,,val
US06121308,N#Cc1ccc(CSc2nc3ccc([N+](=O)[O-])cc3s2)cc1>>N#Cc1ccc(CSc2nc3ccc(N)cc3s2)cc1,[Fe],CC(=O)O,,,,val
US20140309178A1,Cc1ccc(Br)cc1C(=O)c1ccc(Cl)cc1>>Cc1ccc(Br)cc1Cc1ccc(Cl)cc1,,CC#N,,CC[SiH](CC)CC,,val
US04234588,CN(C)Cc1ccc(CSCCN)o1.COc1cc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)ccn1>>COc1cc(Cc2cnc(NCCSCc3ccc(CN(C)C)o3)[nH]c2=O)ccn1,,CCO,,,,val
US20120178751A1,Nc1ccc(-c2ccccc2F)nn1.O=C(CBr)c1ccc(Br)c([N+](=O)[O-])c1>>O=[N+]([O-])c1cc(-c2cn3nc(-c4ccccc4F)ccc3n2)ccc1Br,,CC#N,,,,val
US20140288142A1,O=C(OCC1c2ccccc2-c2ccccc21)N1[C@H]2CCC[C@H]2C[C@]1(Cc1ccccc1)C(=O)[O-]>>O=C(O)[C@@H]1C[C@@H]2CCC[C@@H]2N1C(=O)OCC1c2ccccc2-c2ccccc21,[Pd],CCO,,C1=CCCCC1,,val
US20050171350A1,CC=O.COc1cc(OC)nc(OC)n1>>COc1nc(OC)c(C(C)O)c(OC)n1,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US20140088306A1,CN(C)c1ccc(-c2cnc3cc(OCCO[Si](C)(C)C(C)(C)C)ccc3n2)cc1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCCOc2ccc3nc(-c4ccc(N(C)C)cc4)cnc3c2)cc1,CN(C)c1ccncc1,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20020115674A1,O=c1c2cc(F)c(N3CCCC3)cc2n(-c2ccc(F)cc2)c(=O)n1OCc1ccccc1>>O=c1c2cc(F)c(N3CCCC3)cc2n(-c2ccc(F)cc2)c(=O)n1O,[Pd],,,,,val
US05063235,CCOC(=O)CCCN1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1>>OCCCCN1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080161294A1,CCOC(=O)[C@@H](C)NC(=O)c1cc(F)ccc1N>>C[C@H]1NC(=O)c2cc(F)ccc2NC1=O,,CC(=O)O,,,,val
US20110046169A1,CCOC(=O)c1cn(C)n(-c2ccccc2OC)c1=O>>COc1ccccc1-n1c(=O)c(C(=O)O)cn1C,,CO,,C1CCOC1,[Na+].[OH-],val
US20030144308A1,Br.CCOc1cc2ncnc(Nc3cccc(C(=O)CBr)c3)c2cc1OCC.CNC(N)=S>>Br.Br.CCOc1cc2ncnc(Nc3cccc(-c4csc(NC)n4)c3)c2cc1OCC,,CCO,,,,val
US20120094972A1,CCCC[Sn](CCCC)(CCCC)c1cc(C)ccn1.Cc1c(Cl)nc2ncccc2c1Cl>>Cc1ccnc(-c2nc3ncccc3c(Cl)c2C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20020028823A1,CC(=O)O[C@H](C)CCCCn1c(=O)c2c(nc(C)n2Cc2ccccc2)n(C)c1=O>>Cc1nc2c(c(=O)n(CCCC[C@@H](C)O)c(=O)n2C)n1Cc1ccccc1,,CCOCC,CO,Cl,,val
US20120232070A1,CC(C)(C)OC(=O)N(N)C(=O)c1ccc(Cc2cc3cc(C(F)(F)F)ccc3n2S(=O)(=O)c2cccc(C(C)(C)C)c2)cc1>>CC(C)(C)c1cccc(S(=O)(=O)n2c(Cc3ccc(C(=O)NN)cc3)cc3cc(C(F)(F)F)ccc32)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130059883A1,NC(=O)c1cccc(C(=O)O)n1>>N#Cc1cccc(C(=O)O)n1,,O=P(Cl)(Cl)Cl,,,,val
US05571825,COC(=O)CS.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>COC(=O)CSC(c1ccccc1)(c1ccccc1)c1ccccc1,,Cc1ccccc1,,,,val
US20150307451A1,COC(=O)c1cc(Cc2ccc(C)nc2)c(C)c(C)c1O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1cc(Cc2ccc(C)nc2)c(C)c(C)c1OS(=O)(=O)C(F)(F)F,,CN(C)C=O,,Cl,[H-].[Na+],val
US20100286126A1,CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)CN2CCC(O)CC2)C1.O=C=Nc1ccccc1-c1ccccc1>>CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)CN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)C1,,CN1CCCC1=O,,,,val
US05360815,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=c1cc(-c2ccccc2)c2ccc(O)cc2o1>>O=c1cc(-c2ccccc2)c2ccc(OS(=O)(=O)C(F)(F)F)cc2o1,,ClCCl,,CCN(CC)CC,Cl,val
US20070032517A1,CC(=O)Nc1c(C(C)=O)c(=O)n(C)c2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc12.NCc1ccccc1>>CC1=Nc2c(c(=O)n(C)c3nc(-c4ccc(Cl)cc4Cl)c(-c4ccc(Cl)cc4)cc23)C(C)N1Cc1ccccc1,,ClCCCl,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20090181942A1,CCOC(=O)/C=C(\Cl)C(=O)OCC.COc1ccc(CNc2ccc(Cl)cc2C(O)c2cccc(C(F)(F)F)c2OC)c(OC)c1>>CCOC(=O)/C=C/C(=O)N(Cc1ccc(OC)cc1OC)c1ccc(Cl)cc1C(O)c1cccc(C(F)(F)F)c1OC,,O,,ClCCl,O=C([O-])O.[Na+],val
US20050059810A1,CCN(CC1CCCC1)c1cc2c(cc1C=O)CCC2.NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CCN(CC1CCCC1)c1cc2c(cc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CCC2,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20060247292A1,C#CC(C)(C)c1ccccc1Cl.CCOC(=O)C(=O)C(F)(F)F>>CCOC(=O)C(O)(C#CC(C)(C)c1ccccc1Cl)C(F)(F)F,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US04814454,Nc1ccc(O)cc1.Oc1ccc2cc(Br)ccc2c1>>Oc1ccc(Nc2ccc3cc(Br)ccc3c2)cc1,,O,,O=S([O-])O.[Na+],,val
US20150133510A1,NCc1ccccc1.O=Cc1ccc(F)cc1>>Fc1ccc(CNCc2ccccc2)cc1,,CO,,[BH3-]C#N.[Na+],,val
US20090069288A1,CCOc1cccc(C(=O)Cl)c1.Nc1cc(-c2ccncc2)no1>>CCOc1cccc(C(=O)Nc2cc(-c3ccncc3)no2)c1,,CC#N,,c1ccncc1,,val
US05162326,CCCn1c(=O)cc(Cl)n(Cc2ccc(-c3ccccc3-c3nnnn3C(c3ccccc3)(c3ccccc3)c3ccccc3)cc2)c1=O.SCc1ccccc1>>CCCn1c(=O)cc(SCc2ccccc2)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05684032,CCOC(=O)c1[nH]c2ccccc2c1Br>>O=C(O)c1[nH]c2ccccc2c1Br,,CCO,O,[Na+].[OH-],,val
US20100260710A1,C=CCCCCNC.O=C(n1ccnc1)n1ccnc1>>C=CCCCCN(C)C(=O)n1ccnc1,,CN(C)C=O,,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US20100105667A1,CCOC(=O)c1ccc([N+](=O)[O-])cn1>>O=[N+]([O-])c1ccc(CO)nc1,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US20110201802A1,O=P(Cl)(Cl)Cl.c1ccc2c(c1)cnc1ccccc12>>Clc1ccc2cnc3ccccc3c2c1,,O,,CN(C)c1ccccc1,,val
US20150368260A1,CNCCOC.O=C(O)c1cnc(O)cn1.O=S(Cl)Cl>>CNC(=O)c1cnc(Cl)cn1,,CN(C)C=O,,,,val
US20150065343A1,CNC(=O)NN.Cc1cc(/C=C/C(=O)NC(c2cccc(C(F)(F)F)c2)C(F)(F)F)sc1C=O>>CNC(=O)N/N=C/c1sc(/C=C/C(=O)NC(c2cccc(C(F)(F)F)c2)C(F)(F)F)cc1C,,CCO,,Cl,,val
US20120309739A1,CN(CCO)c1nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c(=O)n1C>>CN(CCO)c1nc2oc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)c2c(=O)n1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050090529A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCc1cncc(Br)c1C>>Cc1c(Br)cncc1CN(C)C(=O)OC(C)(C)C,,C1CCOC1,,[Na+].[OH-],,val
US20050070592A1,Cc1c(-c2ccccc2)n(Cc2ccccc2)c2cc(-c3ccc(OCC#N)cc3)ccc12.[N-]=[N+]=[N-]>>Cc1c(-c2ccccc2)n(Cc2ccccc2)c2cc(-c3ccc(OCc4nnn[nH]4)cc3)ccc12,,CN(C)C=O,,[Cl-].[NH4+],,val
US20090200514A1,CC[C@@H]1CC[C@@H](CBr)CC1.Oc1cccc(F)c1F>>CC[C@@H]1CC[C@@H](COc2cccc(F)c2F)CC1,,CN(C)C=O,Cc1ccccc1,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20150218187A1,COC(=O)C=C1CCC(c2ccc(O)cc2)CC1.C[S+](C)(C)=O>>COC(=O)C1CC12CCC(c1ccc(O)cc1)CC2,,CCOCC,CS(C)=O,[H-].[Na+],,val
US04387101,CCOc1ccc(C(O)C#N)cc1OCC.O=S(Cl)Cl>>CCOc1ccc(C(Cl)C#N)cc1OCC,,ClC(Cl)Cl,,,,val
US05990101,COC(=O)Nc1csc(CNC=O)n1>>COC(=O)Nc1csc2cncn12,,Cc1ccccc1,,O=P(Cl)(Cl)Cl,,val
US20030087901A1,COc1ccc(CC(=O)O)cc1C>>Cc1cc(CC(=O)O)ccc1O,,ClCCl,,BrB(Br)Br,,val
US20070093521A1,CCOc1cc(C=O)cc(OCC)c1F.COC(=O)c1cccc2oc(NC3CCNCC3)nc12>>CCOc1cc(CN2CCC(Nc3nc4c(C(=O)OC)cccc4o3)CC2)cc(OCC)c1F,,CC(=O)O,CCO,CCN(C(C)C)C(C)C,[BH3-]C#N.[Na+],val
US20150005329A1,CSCc1cccc(N)c1.Fc1ccc(-c2nc(Cl)ncc2F)c(OCc2ccccc2)c1>>CSCc1cccc(Nc2ncc(F)c(-c3ccc(F)cc3OCc3ccccc3)n2)c1,,CCCCO,CCOC(C)=O,C1COCCO1,Cl,val
US20080070894A1,CC(C)(C)OC(=O)N1CCN(c2ccc(C#N)cn2)CC1.C[Mg]Br>>CC(N)c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20070032531A1,C=CCCCCCCCCC(=O)Cl.Nc1nc2cc(Cl)ccc2o1>>C=CCCCCCCCCC(=O)Nc1nc2cc(Cl)ccc2o1,,c1ccccc1,,,,val
US20110190269A1,COc1cc(Br)ccc1-n1cnc(C)c1.Cc1cc(-c2ccc(C(C)(C)O)c(F)c2)c2nc(N)nn2c1>>COc1cc(Nc2nc3c(-c4ccc(C(C)(C)O)c(F)c4)cc(C)cn3n2)ccc1-n1cnc(C)c1,,CO,ClCCl,,,val
US04262004,Nc1cc(C(=O)c2ccccc2)ccc1Cl.S=C(Cl)Cl>>O=C(c1ccccc1)c1ccc(Cl)c(N=C=S)c1,,C1COCCO1,,,,val
US20040067984A1,CC(C)S(=O)(=O)NC1CCCC1(O)c1ccc(OCC#N)cc1>>CC(C)S(=O)(=O)NC1CCCC1(O)c1ccc(OCCN)cc1,,C1CCOC1,,CO,,val
US20160222014A1,CN(c1ccccc1CCCl)S(C)(=O)=O.Clc1ncc2cc[nH]c2n1>>CN(c1ccccc1Cn1ccc2cnc(Cl)nc21)S(C)(=O)=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150291584A1,CC(C)CC(=O)Cl.COc1ccc(Br)cc1>>CC(C)CC(=O)c1cc(Br)ccc1O,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US04775692,C=[N+]=[N-].O=C(O)CC1CCCCC1>>COC(=O)CC1CCCCC1,,CCOCC,,,,val
US20090221576A1,CCS(=O)(=O)O.N#Cc1ccc2[nH]c(O)c(-c3ccc(CN4CCOCC4)cn3)c2c1>>CCS(=O)(=O)O.N#Cc1ccc2[nH]c(O)c(-c3ccc(CN4CCOCC4)cn3)c2c1,,CCO,,,,val
US20080070866A1,OCCCCCl.Oc1ccccc1>>OCCCCOc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140296225A1,C=CC[Sn](CCCC)(CCCC)CCCC.O=[N+]([O-])c1ccc(Br)c(C(F)(F)F)c1>>C=CCc1ccc([N+](=O)[O-])cc1C(F)(F)F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,Cc1ccccc1,[Cl-].[Li+],,val
US05428044,Cc1cc(N)cc(C)c1O.NC1=NN(c2ccccc2)CC1>>Cc1cc(NC2=NN(c3ccccc3)CC2)cc(C)c1O,Cc1ccc(S(=O)(=O)O)cc1,ClCCl,,,,val
US20110281840A1,CC(C)(C)Cc1nc2cc(S(=O)(=O)CC3CNC3)ccc2n1CC1CC1.C[Si](C)(C)N=C=O>>CC(C)(C)Cc1nc2cc(S(=O)(=O)CC3CN(C(N)=O)C3)ccc2n1CC1CC1,,ClCCl,,CCN(CC)CC,,val
US05728835,O=C(c1ccc(F)cc1)C1CCNCC1.OCCBr>>O=C(c1ccc(F)cc1)C1CCN(CCO)CC1,,CCN(CC)CC,,,,val
US20120178748A1,Cc1cc(C)c(S(=O)(=O)ON)c(C)c1.Cc1cnc(C)cn1>>Cc1c[n+](N)c(C)cn1.Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1,,ClCCl,,CCOCC,,val
US20080318975A1,CCOC(=O)Cc1c(Cl)ccc2ccc(C)nc12.O=[Se](O)O>>CCOC(=O)Cc1c(Cl)ccc2ccc(C=O)nc12,,C1COCCO1,O,,,val
US20110118283A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2)C1(C#N)c1cccnc1.CC1(C)OC[C@H](CCN)O1>>CC(C)(C)CC1NC(C(=O)NCC[C@H](O)CO)C(c2cccc(Cl)c2)C1(C#N)c1cccnc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US09029536B2,Brc1n[nH]c2cccnc12.CC(C)I>>CC(C)n1nc(Br)c2ncccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05198014,CNC.N#Cc1cnn(-c2ncc(C(F)(F)F)cc2Cl)c1C=CC(=O)Cl>>CN(C)C(=O)C=Cc1c(C#N)cnn1-c1ncc(C(F)(F)F)cc1Cl,,C1CCOC1,,CCN(CC)CC,Cl,val
US20150087825A1,CC(CC1=CCCCC1)(NC(=S)NC(=O)c1ccccc1)c1cc(Br)ccc1F.II>>CC1(c2cc(Br)ccc2F)CC2(CCCCC2I)SC(NC(=O)c2ccccc2)=N1,,C1CCOC1,CCOC(C)=O,,,val
US20070149521A1,CSc1ncc2c(Cl)nccn12.O=C1CCC(=O)N1I>>CSc1nc(I)c2c(Cl)nccn12,,CCOC(C)=O,CN(C)C=O,,,val
US20070249607A1,C=O.N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1>>CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1,CC(=O)O,CC#N,,[BH3-]C#N.[Na+],,val
US20130190334A1,COc1ccc(Cn2cc3c(n2)C(=O)CC2(CCN(Cc4ccccc4)CC2)O3)cc1>>O=C1CC2(CCN(Cc3ccccc3)CC2)Oc2cn[nH]c21,,ClCCCl,,O=C(O)C(F)(F)F,,val
US09181234B2,CCOC(=O)C1(C)CCC(N)CC1.Clc1ncc(Br)cn1>>CCOC(=O)C1(C)CCC(Nc2ncc(Br)cn2)CC1,,CCO,,CCN(C(C)C)C(C)C,O,val
US05854234,CCC1CN=C(OC)C1.[Cl-].[NH4+]>>CCC1CNC(=N)C1.Cl,,CO,,,,val
US20070172421A1,C=C(CBr)C(=O)OC.CN=CC=Cc1ccccc1>>C=C1CC(C=Cc2ccccc2)N(C)C1=O,[Zn],C1CCOC1,,[Cl-].[NH4+],,val
US20150175604A1,CC(=O)Cl.Cc1nnc2ccc3c(cc(-c4ccn(C5(CC#N)CNC5)n4)n3Cc3cccc(Cl)c3)n12>>CC(=O)N1CC(CC#N)(n2ccc(-c3cc4c(ccc5nnc(C)n54)n3Cc3cccc(Cl)c3)n2)C1,,ClCCl,,CCN(CC)CC,,val
US06258829B1,BrC(Br)(Br)Br.CCOC(=O)c1cc2c(nc1C)C(CO)CCCC2>>CCOC(=O)c1cc2c(nc1C)C(CBr)CCCC2,,ClCCl,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])O.[Na+],val
US05166398,Cc1cc(CO)c(C)cc1O.ClCc1ccccc1>>Cc1cc(OCc2ccccc2)c(C)cc1CO,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060111347A1,CC(C)(C)N.CC(C)(C)OC(=O)N[C@@H]1CCCc2cc(C=O)ccc21>>CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)OC(C)(C)C,,CN(C)C=O,CO,CC(=O)O,[BH4-].[Na+],val
US20140179689A1,Clc1cccc(COc2cccc3[nH]ccc23)c1.Nc1nccc(Cl)n1>>Nc1nccc(-n2ccc3c(OCc4cccc(Cl)c4)cccc32)n1,,O,,,,val
US04426525,CCCCCCCCCCCCCCOC[C@@H](O)CO.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCCCCCCCCCCCOC[C@@H](O)COC(c1ccccc1)(c1ccccc1)c1ccccc1,,c1ccncc1,,,,val
US20090270435A1,COC(=O)c1cc(Cl)c(NC(C)=O)c([N+](=O)[O-])c1OC>>COC(=O)c1cc(Cl)c(NC(C)=O)c(N)c1OC,[Ni],CCO,O,[H][H],,val
US20020032189A1,CN(C)CCC1CCc2cc(O)ccc2C1.ClCc1ccc(Br)cc1>>CN(C)CCC1CCc2cc(OCc3ccc(Br)cc3)ccc2C1.Cl,,Cc1ccccc1,O,[H-].[Na+],,val
US20040023807A1,COC(=O)c1snc(-c2ccc(Cl)cc2Cl)c1Cl>>O=C(O)c1snc(-c2ccc(Cl)cc2Cl)c1Cl,,CO,O,[Na+].[OH-],,val
US20110166121A1,CCOC(=O)CC(=O)CCl.NC(=O)/C=C/c1ccccc1>>CCOC(=O)Cc1coc(/C=C/c2ccccc2)n1,,CCOC(C)=O,,,,val
US04276294,CCO.CN1CCN(c2c(-c3ccccc3)oc3ccc(OCc4ccccc4)cc23)CC1.Cl>>CN1CCN(c2c(-c3ccccc3)oc3ccc(O)cc23)CC1.Cl.O,[Pd],CCO,,[H][H],,val
US20090209556A1,CCOC(=O)c1cnn(-c2cccc(Cl)n2)c1C(F)(F)F.OB(O)c1cccnc1F>>CCOC(=O)c1cnn(-c2cccc(-c3cccnc3F)n2)c1C(F)(F)F,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20080027068A1,CC(=O)c1nn(C)c(-c2ccc(F)c(Br)c2)c1O.NNC(=S)Nc1ccc(C(=O)O)cc1>>CC(=NNC(=S)Nc1ccc(C(=O)O)cc1)c1nn(C)c(-c2ccc(F)c(Br)c2)c1O,Cl,O,,CN(C)C=O,,val
US05128448,CCO.CCO.O=Cc1cc2ccccc2s1>>CCOC(=O)/C=C/c1cc2ccccc2s1,,CCO,,C,C[O-].[Na+],val
US20150057260A1,COC(=O)c1cc(N)nc(Cl)n1.COC(CBr)OC>>COC(=O)c1cc2nccn2c(Cl)n1,,CC#N,,,,val
US20140213571A1,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc4c(n3)-c3cc5c(F)cccc5n3C(CO)O4)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc4c(n3)-c3cc5c(F)cccc5n3C(COC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)O4)cc12,CN(C)c1ccncc1,ClCCl,O,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US20060074119A1,C[Mg]Br.Cc1ccccc1COc1cc(-n2cnc3ccccc32)sc1C=O>>Cc1ccccc1COc1cc(-n2cnc3ccccc32)sc1C(C)O,,ClCCl,,CCOCC,,val
US20140329794A1,NCC(O)CN1CCc2ccccc2C1.NS(=O)(=O)c1ccc(C(=O)O)cc1>>NS(=O)(=O)c1ccc(C(=O)NCC(O)CN2CCc3ccccc3C2)cc1,,ClCCl,O,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20080200692A1,Cc1cn(-c2cc(C#N)cc(C(F)(F)F)c2)cn1.OO>>Cc1cn(-c2cc(C(N)=O)cc(C(F)(F)F)c2)cn1,,CN1CCCC1=O,,N,O,val
US20100105664A1,CC(C)(C)OC(=O)N1CCN(c2[nH]c(-c3ccnc(Cl)c3)cc2C#N)CC1.Nc1ccc(N2CCOCC2)cc1>>CC(C)(C)OC(=O)N1CCN(c2[nH]c(-c3ccnc(Nc4ccc(N5CCOCC5)cc4)c3)cc2C#N)CC1,,CN(C)C=O,,,,val
US20050239814A1,BrBr.CC1(C)C(=O)NC(=O)c2c1ccc(N)c2[N+](=O)[O-]>>CC1(C)C(=O)NC(=O)c2c1cc(Br)c(N)c2[N+](=O)[O-],,CC(=O)O,,,,val
US20150057316A1,N#Cc1cccc(S(=O)(=O)Cl)c1.O.c1ccncc1>>N#Cc1cccc(S(=O)(=O)[O-])c1.c1cc[nH+]cc1,,C1CCOC1,,,,val
US06326369B1,CCOC(=O)CCCCCCCC1(C(=O)OCC)Cc2c(c(OC)c(OC)c(OC)c2OC)C1>>CCOC(=O)C1(CCCCCCCC(=O)O)Cc2c(c(OC)c(OC)c(OC)c2OC)C1,,CCO,,[Na+].[OH-],,val
US20120228583A1,CC(C)=O.Nc1cccnc1Nc1ccc2c(c1)OCO2>>CC(C)Nc1cccnc1Nc1ccc2c(c1)OCO2,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060089382A1,COc1cc(OC2CCN(C)CC2)c2c(O)c(C#N)cnc2c1.O=P(Cl)(Cl)Cl>>COc1cc(OC2CCN(C)CC2)c2c(Cl)c(C#N)cnc2c1,,CC#N,,,,val
US20020052346A1,COP(=O)(O)OC.Cc1ccc(-c2ccccc2)cc1>>Cc1ccc(-c2ccc(O)cc2)cc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20160214945A1,CCOC(=O)CC(c1c(F)cccc1F)C(C#C[Si](C)(C)C)c1ccc(F)cc1>>C#CC(c1ccc(F)cc1)C(CC(=O)OC)c1c(F)cccc1F,,CO,,O=C([O-])[O-].[K+].[K+],,val
US06486325B1,COc1ccc(C(C)(O[Si](C)(C)C)C(F)(F)F)c(CCOC(C)=O)c1>>COc1ccc(C(C)(O)C(F)(F)F)c(CCOC(C)=O)c1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20130158006A1,COc1c([N+](=O)[O-])cc2oc(C(=O)N(C)C)cc2c1Cl>>COc1cc2cc(C(=O)N(C)C)oc2cc1N,[Pd],C1CCOC1,CN(C)C=O,[H][H],,val
US20100179211A1,CCN(CC)S(F)(F)F.OC1(c2cccc(F)c2F)CCN(Cc2ccccc2)C1>>Fc1cccc(C2(F)CCN(Cc3ccccc3)C2)c1F,,ClCCl,,O=C([O-])O.[Na+],,val
US04093812,CNN.Clc1ccccn1>>CN(N)c1ccccn1,,COCCO,,,,val
US20060035869A1,CCCCCCCCN=C=O.CCCCCN>>CCCCCCCCNC(=O)NCCCCC,,CCCCCC,,,,val
US20100173933A1,BrCc1nc2cc(Br)ccc2s1.NC(=O)c1c(F)ccc(O)c1F>>NC(=O)c1c(F)ccc(OCc2nc3cc(Br)ccc3s2)c1F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070275968A1,Cc1ccc(B(O)O)cc1.Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(Br)c2)n1>>Cc1ccc(-c2cccc(-c3nc(C(C)C)[nH]c3-c3cccc(C)n3)c2)cc1,,CCOC(C)=O,COCCOC,,,val
US20090030036A1,COc1cc(OC)c2c(O)nccc2c1.COc1ccc(I)cc1>>COc1ccc(-n2ccc3cc(OC)cc(OC)c3c2=O)cc1,[Cu]I,CS(C)=O,O,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(Oc3ccccc3)c(C(=O)O)c2)=C(C)C1=O.c1ccc2c(c1)CCCN2>>COC1=C(OC)C(=O)C(Cc2ccc(Oc3ccccc3)c(C(=O)N3CCCc4ccccc43)c2)=C(C)C1=O,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US04762949,CCCCCCCCC1CC1C(=O)Cl.N=C(N)NCCCCCN>>CCCCCCCCC1CC1C(=O)NCCCCCNC(=N)N,,c1ccncc1,,,,val
US20100292236A1,CCOC(=O)c1cn(C(C)=O)nc1O.COS(=O)(=O)OC>>CCOC(=O)c1c[nH]nc1OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04235912,CC(=O)O.CN1C[C@H](CNN)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21>>CC(=O)NNC[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1,,CC#N,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US07385061B2,NO.Nc1nonc1-c1nc2ccccc2n1CC(=O)c1ccc(Br)cc1>>Nc1nonc1-c1nc2ccccc2n1CC(=NO)c1ccc(Br)cc1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20070032517A1,CC(C)CN.N#Cc1cc(-c2ccc(Cl)cc2)c(-c2ccccc2Cl)nc1Cl>>CC(C)CNc1nc(-c2ccccc2Cl)c(-c2ccc(Cl)cc2)cc1C#N,,C1CCOC1,CCOC(C)=O,,,val
US20100168418A1,CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCN(CCn2c(=O)cnc3ccc(F)cc32)CC1>>O=c1cnc2ccc(F)cc2n1CCN1CCC(NCc2ccc3c(c2)OCCO3)CC1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20060252807A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1nc(-c2ccc(F)cc2)c(C(N)=O)s1>>Cc1nc(-c2ccc(F)cc2)c(C(N)=S)s1,,COCCOC,,,,val
US20160168090A1,BrC1CC1.OCCn1ccc2c(Cl)cccc21>>Clc1cccc2c1ccn2CCOC1CC1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20150018547A1,C=Cc1cc(O)cc2scc(CC(=O)OC)c12>>CCc1cc(O)cc2scc(CC(=O)OC)c12,[Pd],CCOC(C)=O,,,,val
US06194435B1,CCOC(=O)/C=C/CC1CCN(C(=O)OC(C)(C)C)CC1>>CCOC(=O)CCCC1CCN(C(=O)OC(C)(C)C)CC1,[Pd],CCOC(C)=O,,,,val
US20040192688A1,CCCCCCCCN.ClCCCCOc1ccc2ccccc2c1>>CCCCCCCCNCCC(C)Oc1ccc2ccccc2c1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120295885A1,Cn1ccnc1C(=O)C(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Cn1cc(Br)nc1C(=O)C(Cl)(Cl)Cl,,C1CCOC1,,,,val
US04684652,C1CCNCC1.CCOC(=O)c1nc(-c2ccccc2)nc2ccccc12>>O=C(c1nc(-c2ccccc2)nc2ccccc12)N1CCCCC1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US06235922B1,COC(=O)[C@H](Cc1ccccc1C=O)NC(=O)[C@H](CCSC(C)=O)NC(=O)OCc1ccccc1>>COC(=O)[C@H](Cc1ccccc1C=O)NC(=O)[C@H](CCS)NC(=O)OCc1ccccc1,,CO,ClCCl,,,val
US20120053166A1,CC(C)(C)OC(=O)N1CCOC2(CCCC2)C1>>C1CCC2(C1)CNCCO2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060287522A1,CC(C)[Mg]Br.O=C(Cl)c1ccccc1Br>>CC(C)C(O)c1ccccc1Br,,C1CCOC1,,,,val
US04973599,Cn1ccnc1Sc1cc(Cl)ccc1[N+](=O)[O-]>>Cn1ccnc1Sc1cc(Cl)ccc1N,[Ni],CCO,,,,val
US20090131336A1,CC(=O)N1CCNCC1.O=C(OCc1cc(-c2ccco2)on1)n1ccnc1>>CC(=O)N1CCN(C(=O)OCc2cc(-c3ccco3)on2)CC1,,ClCCl,,,,val
US08697685B2,CCN(C(C)C)C(C)C.N#Cc1ccc(-c2cc(N3CCC[C@H](C(=O)NCc4ccccc4)C3)nc(N)n2)cc1F.NN>>Nc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2CCC[C@H](C(=O)NCc3ccncc3)C2)n1,,CCO,,,,val
US20150239895A1,CC(C)(C)OC(=O)Cn1nc(C(N)=O)c2cc(Br)ccc21.OB(O)c1cncnc1>>CC(C)(C)OC(=O)Cn1nc(C(N)=O)c2cc(-c3cncnc3)ccc21,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20130072470A1,CCOC(=O)[C@H]1C[C@@H](O)C[C@H]1C.CS(=O)(=O)Cl>>CCOC(=O)[C@H]1C[C@@H](OS(C)(=O)=O)C[C@H]1C,,ClCCl,,,,val
US20020160996A1,COc1ccc(C(=O)Cl)cc1.Cc1c(C)c2c(c(C)c1N)C(c1ccc(F)cc1)C(C)(C)O2>>COc1ccc(C(=O)Nc2c(C)c(C)c3c(c2C)C(c2ccc(F)cc2)C(C)(C)O3)cc1,,CCCCCC,CCOC(C)=O,,,val
US20150023990A1,CCCc1nc2c(N)nc3cc(OCCCN)ccc3c2n1CC(C)C.O=S(=O)(Cl)CCc1cccc2ccccc12>>CCCc1nc2c(N)nc3cc(OCCCNS(=O)(=O)CCc4cccc5ccccc45)ccc3c2n1CC(C)C,,ClC(Cl)Cl,,CCN(CC)CC,O=C([O-])[O-].[Na+].[Na+],val
US20120245136A1,CC(C)OCC1CC2(CCN(C(=O)OC(C)(C)C)CC2)Oc2ccccc21.Cl>>CC(C)OCC1CC2(CCNCC2)Oc2ccccc21.Cl,,C1COCCO1,,ClCCl,,val
US20110230462A1,C[Si](C)(C)CCOCn1cc(C=O)c2nc(Br)cnc21.O=C1NCc2c(Cl)cccc21>>C[Si](C)(C)CCOCn1cc(C=O)c2nc(N3Cc4c(Cl)cccc4C3=O)cnc21,[Cu]I,CCOC(C)=O,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US20090264416A1,CC(C)(C)OC(=O)N1CCN(Cc2cccc(C(=O)NC3CCC3)c2)CC1>>O=C(NC1CCC1)c1cccc(CN2CCNCC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040006002A1,CC(=O)OC[C@@]1(C)O[C@@H](n2cc(C)c(=O)[nH]c2=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(=O)OC[C@@]1(C)O[C@@H](n2cc(C)c(=S)[nH]c2=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O,,ClCCCl,,,,val
US20030225141A1,CN(C)c1cc[n+](S(=O)(=O)NC(=O)OC(C)(C)C)cc1.Cc1ccccc1C(=O)c1cnc(NCCCN)s1>>Cc1ccccc1C(=O)c1cnc(NCCCNS(=O)(=O)NC(=O)OC(C)(C)C)s1,,ClCCl,,,,val
US20120184587A1,COc1c(F)cc(C(=O)O)cc1Cl.O=S(Cl)Cl>>COc1c(F)cc(C(=O)Cl)cc1Cl,,CN(C)C=O,,Cc1ccccc1,,val
US20140045862A1,C1=COCCC1.c1ccc(CO[C@@H]2CCC[C@H]2c2ccn[nH]2)cc1>>c1ccc(CO[C@@H]2CCC[C@H]2c2ccn(C3CCCCO3)n2)cc1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20150368246A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(N(C)S(C)(=O)=O)c(B(O)O)cc12.Fc1cccc2c1cc1c3nc(Cl)ccc3nc(CN3CC(F)C3)n21>>CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(N(C)S(C)(=O)=O)c(-c3ccc4nc(CN5CC(F)C5)n5c6cccc(F)c6cc5c4n3)cc12,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090143352A1,CN(C)C(=O)c1cc(Br)ccc1N=C=O.CN(CCN)C(=O)OC(C)(C)C>>CN(C)C(=O)c1cc(Br)ccc1NC(=O)NCCN(C)C(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US04464361,CC(=O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O.CCOC1CC(Sc2ccccc2)(Sc2ccccc2)C(=O)N1>>CC(=O)OC[C@H]1O[C@@H](n2cnc3c(NC4NC(=O)CC4(Sc4ccccc4)Sc4ccccc4)ncnc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O,,Cc1ccccc1,,,,val
US20060252759A1,C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3cc4c(nc3N21)COC4>>C[C@@H]1CN(C)C[C@H]2Cc3cc4c(nc3N21)COC4,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150080364A1,CC(C)(C)OC(=O)N1CCNCC1.COC(=O)c1ccc(C=O)c(Cl)c1>>COC(=O)c1ccc(CN2CCN(C(=O)OC(C)(C)C)CC2)c(Cl)c1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05101068,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)CF.Cl>>CC(C)[C@H](N)C(=O)CF.Cl,,CCOCC,,,,val
US20160024049A1,c1ccc(CN2CCC(Oc3cccnc3-c3ccncc3)CC2)cc1>>c1cnc(-c2ccncc2)c(OC2CCNCC2)c1,[Pd],CO,,O=C[O-].[NH4+],,val
US04943666,CC(C)c1cc(Br)cc([N+](=O)[O-])c1O>>Br.CC(C)c1cccc(N)c1O,[Pd],CO,,[H][H],,val
US04311696,CC(C)C(C(=O)Cl)c1ccc(N=[N+]=[N-])cc1.N#CC(O)c1cccc(Oc2ccccc2)c1>>CC(C)C(C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1)c1ccc(N=[N+]=[N-])cc1,,ClCCl,,CCN(CC)CC,,val
US05067967,CC(=O)Nc1ccc(NC(C)=O)c(F)c1.O=[N+]([O-])O>>CC(=O)Nc1cc([N+](=O)[O-])c(NC(C)=O)cc1F,,CC(=O)O,,,,val
US20030088103A1,COc1ccc(S(=O)(=O)Cl)cc1.Nc1cc(C(F)(F)F)ccc1Oc1cncc(Cl)c1>>COc1ccc(S(=O)(=O)Nc2cc(C(F)(F)F)ccc2Oc2cncc(Cl)c2)cc1,,CCOCC,,,,val
US20080090839A1,C#CCOc1ccc(OCC2CCCN2C(=O)OC(C)(C)C)cc1.Ic1ccccc1>>CC(C)(C)OC(=O)N1CCCC1COc1ccc(OCC#Cc2ccccc2)cc1,Cl[Pd]Cl,O,,C1CCNC1,,val
US20050164989A1,NN1CCCC(NC(=O)OCc2ccccc2)([PH](=O)NC(=O)c2ccccc2)C1=O>>NN1CCCC(N)([PH](=O)NC(=O)c2ccccc2)C1=O,[Pd],CCO,,,,val
US06235787B1,CC(C)C[C@@H](C(=O)NN(CCN1C(=O)c2ccccc2C1=O)S(C)(=O)=O)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1>>CC(C)C[C@@H](C(=O)NN(CCN)S(C)(=O)=O)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1,,CO,,NN,O,val
US05514680,O=c1[nH]c2cc(C(F)(F)F)c([N+](=O)[O-])c(Cl)c2[nH]c1=O>>Nc1c(C(F)(F)F)cc2[nH]c(=O)c(=O)[nH]c2c1Cl,,CCO,,Cl[Sn]Cl,,val
US20150329538A1,Nc1c(Br)cccc1C(=O)O.S=C=Nc1ccccc1>>O=c1c2cccc(Br)c2[nH]c(=S)n1-c1ccccc1,,CC(C)(C)O,,,,val
US05852011,COC(=O)c1cc(N(CCCl)CCCl)cc(N(CCCl)CCCl)c1>>O=C(O)c1cc(N(CCCl)CCCl)cc(N(CCCl)CCCl)c1,,Cl,,,,val
US20140275077A1,COc1cc(NC=C2C(=O)OC(C)(C)OC2=O)cc(OC)c1>>COc1cc(OC)c2c(=O)cc[nH]c2c1,,c1ccc(Oc2ccccc2)cc1,,CCCCCC,,val
US20090209755A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(NC1=N[C@@]2(c3cc(Br)cs3)CCOC[C@H]2CS1)c1ccccc1>>CC(C)(C)OC(=O)N(C(=O)c1ccccc1)C1=N[C@@]2(c3cc(Br)cs3)CCOC[C@H]2CS1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20160244461A1,CCNC(N)=O.CCOC(=O)CC(=O)OCC>>CCN1C(=O)CC(=O)NC1=O,,CCO,,C,C[O-].[Na+],val
US20120252779A1,COCCOC(=O)c1cccc(OCCOC)c1C>>COCCOc1cccc(CO)c1C,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US04034094,CCN1CCNCC1.CCOC(=O)c1cn(CC)c2nc(Cl)ncc2c1=O>>CCOC(=O)c1cn(CC)c2nc(N3CCN(CC)CC3)ncc2c1=O,,ClC(Cl)Cl,,,,val
US20140256926A1,CCCC[P+](CCCC)(CCCC)CCCNC(=O)CCC1(CCC(=O)OC(C)C)OCCO1.[Br-]>>CCCC[P+](CCCC)(CCCC)CCCNC(=O)CCC1(CCC(=O)O)OCCO1.[Br-],,CO,,O,[Li+].[OH-],val
US20090149439A1,CS(=O)(=O)Cl.Cc1cc(C(N)=O)ncc1C(O)c1c(F)ccc(F)c1F>>Cc1cc(C(N)=O)ncc1C(OS(C)(=O)=O)c1c(F)ccc(F)c1F,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,O,val
US20060058337A1,CC1c2ccccc2-c2ccc(Cl)cc2N1C(=O)c1ccc(O)cc1>>C[C@H]1c2ccccc2-c2ccc(Cl)cc2N1C(=O)c1ccc(O)cc1,,ClC(Cl)Cl,,,,val
US20150065468A1,COC(=O)C(OC)OC.COc1cc([N+](=O)[O-])c(N)cc1OCc1ccccc1>>COc1cc([N+](=O)[O-])c(NC(=O)C(OC)OC)cc1OCc1ccccc1,,CS(C)=O,,[H-].[Na+],,val
US20060089370A1,CC(C)c1ccc(C(C)N)cc1.Clc1csc2ncnc(Cl)c12>>CC(C)c1ccc(C(C)Nc2ncnc3scc(Cl)c23)cc1,,CN(C)C=O,O,CCN(CC)CC,,val
US20160046599A1,CC(N)=NO.O=C(Cl)c1cc(F)ccc1Br>>Cc1noc(-c2cc(F)ccc2Br)n1,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20030176698A1,COC(=O)CBr.O=C1Nc2nc(C3CCCC3)n(Cc3ccccc3)c2C2=N[C@H](Cc3ccccc3)CN12>>COC(=O)CN1C(=O)N2C[C@@H](Cc3ccccc3)N=C2c2c1nc(C1CCCC1)n2Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080132539A1,CC(C)(C)OC(=O)N[C@@H](CCC(=O)Nc1cc(Cl)c(Cl)cc1N)C(=O)OCc1ccccc1.CCC=O>>CCCNc1cc(Cl)c(Cl)cc1NC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1,,CC(Cl)Cl,,[Na+].[OH-],,val
US20130296290A1,CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)n1cccn1.NCC1(c2nnc(C3CC[C@@H]4CN3C(=O)N4OCc3ccccc3)o2)CC1>>CC(C)(C)OC(=O)N=C(NCC1(c2nnc(C3CC[C@@H]4CN3C(=O)N4OCc3ccccc3)o2)CC1)NC(=O)OC(C)(C)C,,CO,,CCN(CC)CC,,val
US04022769,C[C@@H]1CC(=O)C=C2CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]3[C@]21C>>C[C@@H]1CC(=O)CC2=CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]3[C@]21C,,CS(C)=O,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20040077726A1,COC(=O)C=Cc1cccc(S(=O)(=O)Cl)c1.Nc1ccccc1>>COC(=O)C=Cc1cccc(S(=O)(=O)Nc2ccccc2)c1,,ClCCl,,c1ccncc1,,val
US04802909,Cc1cc(O)nc(Nc2ccccc2[N+](=O)[O-])n1.O=P(Cl)(Cl)Cl>>Cc1cc(Cl)nc(Nc2ccccc2[N+](=O)[O-])n1,,ClC(Cl)Cl,,CN(C)C=O,O,val
US20160152543A1,CCOC(=O)C(=O)OCC.Clc1cc2ncccc2c(I)c1OCc1ccccc1>>CCOC(=O)C(=O)c1c(OCc2ccccc2)c(Cl)cc2ncccc12,,C1CCOC1,,,,val
US20140107139A1,CC(C)(C)[Si](C)(C)Oc1ccc(CO)c(Br)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)[Si](C)(C)Oc1ccc2c(c1)C(O)(C(F)(F)F)OC2,,CCCCCC,,C1CCOC1,[Li]CCCC,val
US20150291573A1,CI.O=S(=O)(c1cccc(C(F)(F)F)c1)C1COC(c2ccc(Cl)cc2)C1>>CC1(S(=O)(=O)c2cccc(C(F)(F)F)c2)COC(c2ccc(Cl)cc2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20140171422A1,COS(=O)(=O)c1ccc(C)cc1.O=c1[nH]cnc2c(Br)scc12>>Cn1cnc2c(Br)scc2c1=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06159904,CC(=O)c1ccc2c(c1C)C(=O)C(C)(C)CS2(=O)=O.O>>Cc1c(C(=O)O)ccc2c1C(=O)C(C)(C)CS2(=O)=O,,C1COCCO1,O,[Na+].[O-]Cl,,val
US06884801B1,CSc1ccccc1NCC1=NCCN1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ccccc1NCC1=NCCN1.Cl,,ClCCl,,,,val
US03975535,CCO.O=Cc1ccc(Br)cc1C(=O)O>>O=C(O)c1cc2ccc(Br)cc2c(=O)o1,,CCO,O,,,val
US20020103211A1,CC(=O)N1CCn2c1nc1c2c(=O)n(CCCC[C@H](C)O)c(=O)n1C.CS(=O)(=O)OS(C)(=O)=O>>CC(=O)N1CCn2c1nc1c2c(=O)n(CCCC[C@H](C)OS(C)(=O)=O)c(=O)n1C,CN(C)c1ccncc1,ClCCl,,O,,val
US20050245530A1,COc1ccc(CNc2cc(Oc3ccc(N)cc3F)ncn2)cc1.O=C=NC(=O)Cc1ccc(F)cc1>>COc1ccc(CNc2cc(Oc3ccc(NC(=O)NC(=O)Cc4ccc(F)cc4)cc3F)ncn2)cc1,,C1CCOC1,,Cc1ccccc1,,val
US20100234340A1,CC(C)(C)OC(=O)N1CCn2cc(C(=O)N3CCC4(CC3)CCN(c3ccncc3)CC4)nc2C1>>O=C(c1cn2c(n1)CNCC2)N1CCC2(CC1)CCN(c1ccncc1)CC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150087646A1,COc1cc(C(=O)NC(=O)N(NC(=O)OC(C)(C)C)c2c(Cl)cccc2Cl)ccc1[N+](=O)[O-]>>COc1cc(-c2nn(-c3c(Cl)cccc3Cl)c(=O)[nH]2)ccc1[N+](=O)[O-],,ClCCl,,O=C(O)C(F)(F)F,,val
US04999436,CC(=O)OC(C)=O.Cc1ccccc1-c1sc(-c2ccccc2)cc1O>>CC(=O)Oc1cc(-c2ccccc2)sc1-c1ccccc1C,CN(C)c1ccncc1,CC#N,,CCN(CC)CC,,val
US08153647B2,CC1(C)OB(c2ccc(Cl)c(CS(=O)(=O)C(C)(C)C)c2)OC1(C)C.CCOC(=O)CCc1ccc(OS(=O)(=O)C(F)(F)F)c(OCCCOC)c1>>CCOC(=O)CCc1ccc(-c2ccc(Cl)c(CS(=O)(=O)C(C)(C)C)c2)c(OCCCOC)c1,,CCO,COCCOC,[Cs+].[F-],,val
US20080076745A1,CC(C)(C)OC(=O)NCCC[C@@H](CN)NC(=O)OC(C)(C)C.CC(C)(C)OC(=O)NCCC[C@H](NC(=O)OCc1ccccc1)C(=O)O>>CC(C)(C)OC(=O)NCCC[C@@H](CNC(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20050282858A1,COC(=O)C1(c2ccc(-c3csc(N)n3)cc2)CC1>>Nc1nc(-c2ccc(C3(C(=O)O)CC3)cc2)cs1,,C1CCOC1,O,[Li+].[OH-],,val
US20030139418A1,O=C1COCc2ccc(-c3ccccc3)nc21>>OC1=COCc2ccc(-c3ccccc3)nc21,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20020183362A1,BrCc1ccccc1.CSc1ccc(C(C#N)O[Si](C)(C)C)cc1F>>CSc1ccc(C(=O)Cc2ccccc2)cc1F,,C1CCOC1,CCOC(C)=O,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20100173905A1,O=C(O)c1ccccc1Nc1ccccc1O>>O=C1Oc2ccccc2Nc2ccccc21,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20100137303A1,CN(C)CCO.O=[N+]([O-])c1cnc(Cl)c(Br)c1>>CN(C)CCOc1ncc([N+](=O)[O-])cc1Br,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20080167307A1,Cc1ccc(C(N)=O)cc1.O=C(CCl)CCl>>Cc1ccc(-c2nc(CCl)co2)cc1,,CCO,,,,val
US20080171739A1,CCOC(=O)CCc1ccc(Br)nc1>>OCCCc1ccc(Br)nc1,,C1CCOC1,,O,[BH4-].[Li+],val
US20090149475A1,CC(C)(C)OC(=O)n1cc(CNc2nc[nH]c2C(N)=O)c2cc(Cl)ccc21.O=C(N=C=S)c1ccccc1>>CC(C)(C)OC(=O)n1cc(Cn2c(=S)[nH]c(=O)c3[nH]cnc32)c2cc(Cl)ccc21,,ClCCl,,,,val
US20060009453A1,CC1(C)OB(c2ccccc2O)OC1(C)C.O=[N+]([O-])c1ccc(F)cc1>>CC1(C)OB(c2ccccc2Oc2ccc([N+](=O)[O-])cc2)OC1(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090054508A1,C#CC(=O)OC.[H]/N=C(/NO)c1ccccc1C=Cc1n[nH]c2ccccc12>>COC(=O)c1cnc(-c2ccccc2/C=C/c2n[nH]c3ccccc23)[nH]1,,CO,,O,,val
US20100256121A1,Cc1ccc(-n2nccn2)c(C(=O)N2CCN(C(=O)OC(C)(C)C)C(C)C(C)C2)c1.Cl>>Cc1ccc(-n2nccn2)c(C(=O)N2CCNC(C)C(C)C2)c1.Cl,,CCOC(C)=O,,,,val
US20110130380A1,CC1(C)COC(CNc2nc(OCc3ccccc3)ccc2F)CO1>>CC1(C)COC(CNc2nc(O)ccc2F)CO1,[Pd],CO,,,,val
US20100240611A1,CC1(C)C2CC3OB(C4CCCN4C(=O)CN(C(=O)OCc4ccccc4)C4CCN(C(=O)OCc5ccccc5)C4)OC3(C)C1C2>>CC1(C)[C@@H]2C[C@H]1C[C@H]1OB([C@@H]3CCCN3C(=O)CN[C@@H]3CCNC3)O[C@@]21C,[Pd],CO,Cc1ccccc1,,,val
US20030087932A1,COc1c(O[Si](C(C)C)(C(C)C)C(C)C)cccc1C(=O)C1CCN(C(=O)OC(C)(C)C)CC1>>COc1c(O[Si](C(C)C)(C(C)C)C(C)C)cccc1C(=O)C1CCNCC1,,O=C(O)C(F)(F)F,,O=C([O-])O.[Na+],,val
US20090163512A1,C=C(N=Cc1cc(C)ccc1OC)O[Si](C)(C)C.COC(=O)C(C)(C)Oc1ccc(Cl)cc1/C=C1\C(=O)N(C(=O)OC(C)(C)C)c2cc(Cl)ccc21>>COC(=O)C(C)(C)Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(C)ccc2OC)C12C(=O)Nc1cc(Cl)ccc12,,Cc1ccccc1,,,,val
US04673692,CC(C)(C)c1cc(C(=O)c2ccccc2)cc(C(C)(C)C)c1O.NNC(N)=O>>CC(C)(C)c1cc(C(=NNC(N)=O)c2ccccc2)cc(C(C)(C)C)c1O,,c1ccncc1,,CCOC(C)=O,Cl,val
US20110195954A1,O=C1Nc2ccccc2C12CCC2>>c1ccc2c(c1)NCC21CCC1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20160185773A1,OCc1ccc(CCl)cc1.Oc1ccccn1>>O=c1ccccn1Cc1ccc(CO)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110269956A1,COC(=O)N[C@H](C(=O)OC)[C@@H]1CCCOC1>>COC(=O)N[C@H](C(=O)O)[C@@H]1CCCOC1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US04210743,CCCC1CC=CCCC=CCC(CCC)N=N1>>CCCC(N)CCCCCCCCC(N)CCC,[Rh],CC(C)(C)O,,[H][H],,val
US20150182503A1,COC(=O)Cc1ccc(C(F)(F)F)cc1.O=C1CCC(=O)N1Br>>COC(=O)C(Br)c1ccc(C(F)(F)F)cc1,,c1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20140107194A1,CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.CNC(=O)c1ccc(C[C@@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@H]2O)cc1>>CNC(=O)c1ccc(C[C@@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@H]2OC(=O)[C@@H](N)CC(C)C)cc1,CN(C)c1ccncc1,CCOC(C)=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20120029190A1,N#Cc1cccc(C(=O)Cl)c1.c1ccc(-c2nc3c(o2)CNCC3)nc1>>N#Cc1cccc(C(=O)N2CCc3nc(-c4ccccn4)oc3C2)c1,,ClCCl,,,,val
US20060258860A1,NC(=O)[C@@H]1C[C@H](F)CN1C(=O)OCc1ccccc1>>N#C[C@@H]1C[C@H](F)CN1C(=O)OCc1ccccc1,,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20100292253A1,CCOC(=O)C(Cl)C(=O)C(F)(F)F.NC(=S)c1cccnc1>>CCOC(=O)c1sc(-c2cccnc2)nc1C(F)(F)F,,CCO,,CCN(CC)CC,,val
US20030130281A1,N=C(N)c1ccccc1.O=C(CBr)CCCN1C(=O)c2ccccc2C1=O>>O=C1c2ccccc2C(=O)N1CCCc1c[nH]c(-c2ccccc2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160068550A1,Nc1nccc(-c2ccccn2)c1[N+](=O)[O-]>>Nc1nccc(-c2ccccn2)c1N,[Pd],CO,,,,val
US20120277224A1,CCOC(=O)CC(=O)c1ccc(F)cc1.Nc1n[nH]c(N)c1-c1ccccn1>>Nc1nn2c(=O)cc(-c3ccc(F)cc3)[nH]c2c1-c1ccccn1,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150266895A1,CC1CC(NC(=O)OC(C)(C)C)C(C)O1.Cl>>CC1CC(N)C(C)O1.Cl,,CCOCC,,Cl,,val
US05308850,BrCc1nc2ccccc2s1.COC(=O)C(C)(C)Cc1c(C)c2cc(O)ccc2n1Cc1ccc(Cl)cc1>>COC(=O)C(C)(C)Cc1c(C)c2cc(OCc3nc4ccccc4s3)ccc2n1Cc1ccc(Cl)cc1,,CC#N,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070249579A1,CCCC[Sn](C#N)(CCCC)CCCC.O=C(C(=O)N1CCN(c2nnnn2-c2ccccc2)CC1)c1c[nH]c2c(Br)ncc(F)c12>>N#Cc1ncc(F)c2c(C(=O)C(=O)N3CCN(c4nnnn4-c4ccccc4)CC3)c[nH]c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US04342775,O=C1c2cc(Cl)ccc2OCC1n1ccnc1>>OC1c2cc(Cl)ccc2OCC1n1ccnc1,,CO,,O,[BH4-].[Na+],val
US05958954,CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(c2ccc(CC)cc2)=CC(C)(C)O3)cc1>>CCc1ccc(C2=CC(C)(C)Oc3ccc(C#Cc4ccc(C(=O)O)cc4)cc32)cc1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20120202785A1,C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)c(Br)c2n1C.OB(O)c1ccccc1>>C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)c(-c3ccccc3)c2n1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040072309A1,CC(=O)OCC(=O)Cl.COc1ccc(/N=C/c2ncccc2F)cc1>>COc1ccc(N2C(=O)[C@@H](OC(C)=O)[C@H]2c2ncccc2F)cc1,,ClCCl,,CCN(CC)CC,,val
US20100267699A1,Oc1ccc(C2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1>>Oc1ccc(C2CCN(C3=Nn4c(nnc4C(F)(F)F)CC3)CC2)cc1,[Pd],CO,,,,val
US20120165298A1,BrBr.CC(C)(C)OC(=O)N1CCc2nncn2CC1>>CC(C)(C)OC(=O)N1CCc2nnc(Br)n2CC1,,O,,Cl,[Na+].[OH-],val
US20150166564A1,CCOC(=O)C(C)C#N.NNc1ccccc1>>Cc1c(N)n(-c2ccccc2)[nH]c1=O,,C1COCCO1,,,,val
US20160176857A1,Cc1cc(C=O)cc(C)c1O.Cc1cc(Nc2n[nH]c(N)c2C(N)=O)ccc1N1CCN(C)CC1>>Cc1cc(Nc2n[nH]c(NCc3cc(C)c(O)c(C)c3)c2C(N)=O)ccc1N1CCN(C)CC1,,CC(=O)O,CCO,O,[BH4-].[Na+],val
US04737496,CN1CCN2c3ccccc3Cn3c(c(C(=O)[O-])c4ccccc43)C2C1>>CN1CCN2c3ccccc3Cn3c(c(CO)c4ccccc43)C2C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04588732,N#CCc1ccc(CCc2cccc3cncn23)cc1>>c1ccn2cncc2c1,,[Na+],[OH-],O=S(=O)(O)O,,val
US06300352B1,C[C@H](Oc1ccc(B(O)O)cc1)[C@H](O)CCc1cccnc1.NC(=O)COc1cccc(Br)c1>>C[C@H](Oc1ccc(-c2cccc(OCC(N)=O)c2)cc1)[C@H](O)CCc1cccnc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20100210594A1,CCOP(=O)(CN(c1ccc2c(c1)CCN2c1ncccn1)S(=O)(=O)c1cc(Cl)cc(Cl)c1)OCC>>O=P(O)(O)CN(c1ccc2c(c1)CCN2c1ncccn1)S(=O)(=O)c1cc(Cl)cc(Cl)c1,,CO,ClCCl,,,val
US20020103141A1,CCOC(=O)C1=Cc2ccc(C(C)(C)C)cc2OC1C(F)(F)F.ClCl>>CCOC(=O)C1=Cc2cc(Cl)c(C(C)(C)C)cc2OC1C(F)(F)F,[Zn],CCOC(C)=O,,CC(=O)O,O,val
US04146715,Nc1nc(N)c2ncn(COCCO)c2n1.O=CO>>Nc1nc(N)c2ncn(COCCOC=O)c2n1,,O=CO,,CCOCC,,val
US20150105351A1,COc1ccccc1O.O=[N+]([O-])c1cc(F)cc(I)c1>>COc1ccccc1Oc1cc(I)cc([N+](=O)[O-])c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06130239,C#CC1(O)CCOCC1.COc1cc[nH]c1/C=C1\C(=O)Nc2ccc([N+](=O)[O-])c(Br)c21>>COc1cc[nH]c1/C=C1\C(=O)Nc2ccc([N+](=O)[O-])c(C#CC3(O)CCOCC3)c21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCN(CC)CC,CN(C)C=O,,,val
US04322440,CC1CCCC(=O)N1.CC1CCCC(=O)N1O>>CC(N)CCCC(=O)O,[Pd],,,[H][H],,val
US20110218177A1,O=P(CCCOC1CCCCO1)(OCc1ccccc1)OCc1ccccc1>>O=P(CCCO)(OCc1ccccc1)OCc1ccccc1,,CCO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20030139417A1,COC(=O)/C=C/C(=O)c1cc(Br)c(N)c(Br)c1.C[S+](C)(C)=O>>COC(=O)[C@@H]1C[C@H]1C(=O)c1cc(Br)c(N)c(Br)c1,,CS(C)=O,,[H-].[Na+],,val
US20090186879A1,CCC(NC(C)=O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl.CI>>CCC(c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl)N(C)C(C)=O,,CN(C)C=O,O,[H-].[Na+],,val
US20140194440A1,CCOc1ncccc1C1(N)C(=O)Nc2cc(F)c(C#N)cc21.COc1ccc(S(=O)(=O)Cl)c(OC)c1>>CCOc1ncccc1C1(N)C(=O)N(S(=O)(=O)c2ccc(OC)cc2OC)c2cc(F)c(C#N)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20100234815A1,CCCCCCCCCCCC(=O)O.NC(=NCCCCCCN=C(N)/N=C(\N)Nc1ccc(Cl)cc1)/N=C(/N)Nc1ccc(Cl)cc1>>CCCCCCCCCCCC(=O)[O-].N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1,,CC(C)O,,,,val
US20100004465A1,Cc1cc(OCc2ccccc2)c(Br)cc1C(=O)O.O=C(Cl)C(=O)Cl>>Cc1cc(OCc2ccccc2)c(Br)cc1C(=O)Cl,CN(C)C=O,ClC(Cl)Cl,,,,val
US20090023710A1,CS(=O)(=O)Cl.O=C(NC1CCNCC1)c1ccccc1Oc1ccc(Cl)cc1Cl>>CS(=O)(=O)N1CCC(NC(=O)c2ccccc2Oc2ccc(Cl)cc2Cl)CC1,,ClCCl,,CCN(CC)CC,,val
US05935966,CCOC(=O)c1cnc(Cl)nc1C(=O)OCC.NN>>CCOC(=O)c1cnc(NN)nc1C(=O)OCC,,C1CCOC1,,,,val
US20110130414A1,CCOC(=O)C(C(=O)OCC)C(=O)OCC.Nc1nc2c(s1)CN(c1ccc(C(F)(F)F)cn1)CC2>>CCOC(=O)c1c(O)nc2sc3c(n2c1=O)CCN(c1ccc(C(F)(F)F)cn1)C3,,Cc1ccccc1C,,,,val
US20080194549A1,COC(=O)c1ccc2c(C)c[nH]c2c1.COCCCBr>>COCCCn1cc(C)c2ccc(C(=O)OC)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20130303524A1,C=CC1CCCCN1S(C)(=O)=O.O=C(OO)c1cccc(Cl)c1>>CS(=O)(=O)N1CCCCC1C1CO1,,ClCCl,,,,val
US20110021351A1,CC(C)C(=O)Cl.Oc1nc2nccnc2c(O)c1-c1ncc(Cl)cc1Cl>>CC(C)C(=O)Oc1c(-c2ncc(Cl)cc2Cl)c(=O)[nH]c2nccnc12,,ClCCl,,O,c1ccncc1,val
US20160257682A1,CI.COC(=O)C(C)(C)C1(O)CN(C(=O)OCc2ccccc2)C1.S=C=S>>COC(=O)C(C)(C)C1(OC(=S)SC)CN(C(=O)OCc2ccccc2)C1,,C1CCOC1,,[H-].[Na+],,val
US20160122359A1,CC(C)(C)OC(=O)NCC(N)=O.CN(C)C=O>>CN(C)/C=N/C(=O)CNC(=O)OC(C)(C)C,,C1CCOC1,,CC(=O)N(C)C,,val
US20070197626A1,CCOC(=O)Cc1cccc(OCC(=O)N2CC(C)(C)c3cc(-c4ccc(C(F)(F)F)cc4)ccc32)c1>>CC1(C)CN(C(=O)COc2cccc(CC(=O)O)c2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc21,,CCO,,Cl,[Na+].[OH-],val
US20070197512A1,CC(C)C1CNc2cccc(Br)c2O1.CCOC(=O)/C=C/C(=O)Cl>>CCOC(=O)/C=C/C(=O)N1CC(C(C)C)Oc2c(Br)cccc21,,CCOC(C)=O,,O,c1ccncc1,val
US20120101064A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)C1CCN(c2ccc3nc[nH]c3n2)CC1>>CN(C)C1CCN(c2ccc3ncn(C(=O)OC(C)(C)C)c3n2)CC1,,O,,C1CCOC1,O=C([O-])O.[Na+],val
US04011319,COc1ccc(CCNCc2ccccc2)cc1OC.Clc1ccccc1C1CO1>>COc1ccc(CCN(Cc2ccccc2)CC(O)c2ccccc2Cl)cc1OC,,CO,,,,val
US20110144105A1,CS(=O)(=O)c1ccc(C(CC2CCCC2)c2cc3cc(CC=O)cnc3[nH]2)cc1>>CS(=O)(=O)c1ccc(C(CC2CCCC2)c2cc3cc(CCO)cnc3[nH]2)cc1,,CO,,[BH4-].[Na+],,val
US20120309787A1,CCOC(=O)C(C#N)=Cc1ccnc2ccccc12.Oc1cccc(O)c1>>CCOC(=O)C1=C(N)Oc2cc(O)ccc2C1c1ccnc2ccccc12,,CCO,,C1CCNCC1,,val
US20130150339A1,COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(=O)[nH]cnc3c2)c(OC)c1.O=P(Cl)(Cl)Cl>>COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(Cl)ncnc3c2)c(OC)c1,,CCOC(C)=O,Cc1ccccc1,,,val
US20070254868A1,CC(C)(C)N.O=C(Nc1cnccc1Nc1cccc(F)c1F)c1cccnc1F>>CC(C)(C)Nc1ncccc1C(=O)Nc1cnccc1Nc1cccc(F)c1F,,CN1CCCC1=O,O,,,val
US04590268,CC1(C)CCCC(C)(C)N1.CCCCCCCCNCCCCCCCC.O=C(Cl)Cl>>CCCCCCCCN(CCCCCCCC)C(=O)N1C(C)(C)CCCC1(C)C,,Cc1ccccc1,,,,val
US05105017,CCCc1c(CCl)ccc(C(C)=O)c1O.OCCCCO>>CCCc1c(COCCCCO)ccc(C(C)=O)c1O,,O,,[H-].[Na+],,val
US05880147,CCCCCC(CC(=O)OCC)c1ccc(CO[Si](C)(C)C(C)(C)C)cc1OC>>CCCCCC(CC(=O)O)c1ccc(CO)cc1OC,,CCO,,[Na+].[OH-],,val
US05099019,CC(=O)[C@H]1C(C)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C>>CC(=O)[C@H]1[C@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C,,c1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20080234237A1,CCN(CC)CCN1CCCc2cc([N+](=O)[O-])ccc21>>CCN(CC)CCN1CCCc2cc(N)ccc21,[Pd],CCO,,[H][H],,val
US05981492,N#C[Cu].O=C(c1ccc(Br)cc1)C1CC1>>N#Cc1ccc(C(=O)C2CC2)cc1,Cl[Fe](Cl)Cl,CN(C)C=O,,Cl,O,val
US20140171430A1,Cc1cc(CO)nc(N2CC3CN(C(=O)OC(C)(C)C)CC3C2)n1>>Cc1cc(CO)nc(N2CC3CNCC3C2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120157430A1,CCOc1c(C(C)N)cc(C)c(C#N)c1-c1cncc(S(C)(=O)=O)c1.Clc1ncnc2c1ncn2C1CCCCO1>>CCOc1c(C(C)Nc2ncnc3c2ncn3C2CCCCO2)cc(C)c(C#N)c1-c1cncc(S(C)(=O)=O)c1,,CCO,,CCN(C(C)C)C(C)C,,val
US04414225,CCCCOC(=O)CO.N#CC1=C(Cl)CCN(Cc2ccccc2)CC1>>CCCCOC(=O)c1oc2c(c1N)CCN(Cc1ccccc1)CC2,,C1COCCO1,,[H-].[Na+],,val
US20060142576A1,C1CSCCN1.COC(=O)c1c(C)nc(S(=O)(=O)Cc2ccccc2)nc1-c1ccc(Cl)cc1Cl>>COC(=O)c1c(C)nc(N2CCSCC2)nc1-c1ccc(Cl)cc1Cl,,C1COCCO1,,,,val
US04803286,CC(=O)Cl.O=C1CCSCC1CO>>CC(=O)OCC1CSCCC1=O,,ClCCl,,CCN(CC)CC,,val
US04638067,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC1CCN1Cc1ccccc1>>CC(C)(C)OC(=O)NCC1CCN1Cc1ccccc1,,CC(C)(C)O,,[Na+].[OH-],,val
US20160237067A1,Cc1ccc(S(=O)(=O)N(C)C)cc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1.Cl>>Cc1ccc(S(=O)(=O)N(C)C)cc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1.Cl,,C1COCCO1,ClCCl,CC#N,,val
US06552069B1,CS(=O)(=O)OCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F.[I-]>>FC(F)(F)C(F)(F)C(F)(F)C(F)(F)CCCI,,CC(C)=O,,O,,val
US20140349993A1,CC1(C)OCC(COc2ccccc2-c2ccc3ncc(C(=O)Nc4cccc(N5CCOCC5)n4)n3n2)O1>>O=C(Nc1cccc(N2CCOCC2)n1)c1cnc2ccc(-c3ccccc3OCC(O)CO)nn12,,CO,,Cl,,val
US20120295886A1,CC(C)(C)OC(=O)NC12CC3CC(=O)C(CC(C3)C1)C2.NO>>CC(C)(C)OC(=O)NC12CC3CC(=NO)C(CC(C3)C1)C2,,CCO,O,Cl,[Na+].[OH-],val
US20120208817A1,COc1ccc(C=O)cc1.NC(N)=O.O=C(Cc1ccccc1)c1ccccc1>>COc1ccc(C2NC(=O)NC(c3ccccc3)=C2c2ccccc2)cc1,,CCO,,Cl,,val
US20100239520A1,Cc1nc(-c2cncc(/C=C/c3ccc(F)cc3)n2)sc1C(=O)NCc1ccc(F)cc1>>Cc1nc(-c2cncc(CCc3ccc(F)cc3)n2)sc1C(=O)NCc1ccc(F)cc1,[Pd],CCO,CCOC(C)=O,,,val
US20100190766A1,CC(C)(C)[Si](C)(C)Cl.O=Cc1ccc(CO)cc1>>CC(C)(C)[Si](C)(C)OCc1ccc(C=O)cc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20030187001A1,COc1cc(-c2cn(C3CCCC3)c3ncnc(Cl)c23)ccc1N.N>>COc1cc(-c2cn(C3CCCC3)c3ncnc(N)c23)ccc1N,,C1COCCO1,,,,val
US05539112,CC(=O)N(CCCCCCBr)c1ccc(-c2cc(=O)c3c(N)c(F)cc(F)c3o2)cc1F>>Nc1c(F)cc(F)c2oc(-c3ccc(NCCCCCCBr)c(F)c3)cc(=O)c12,,C1COCCO1,,Br,O,val
US20030032671A1,COCCN(CC(=O)Nc1ccc(C(C)C)cc1C(F)(F)F)Cc1ccc(OC(C)(C)C(=O)OC(C)(C)C)cc1>>COCCN(CC(=O)Nc1ccc(C(C)C)cc1C(F)(F)F)Cc1ccc(OC(C)(C)C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090281087A1,CC(C)(C)OC(=O)N1CCN(CCOC(=O)Oc2ccc([N+](=O)[O-])cc2)CC1.c1ccc(N2CCNCC2)cc1>>CC(C)(C)OC(=O)N1CCN(CCOC(=O)N2CCN(c3ccccc3)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,,val
US20080280906A1,COc1cc(OCc2ccccc2)ccc1C(=O)N1CCOCC1>>COc1cc(O)ccc1C(=O)N1CCOCC1,[Pd],CO,,O=C[O-].[NH4+],,val
US20120295885A1,N#Cc1cn[nH]c1.O=Cc1c(F)cccc1Br>>N#Cc1cnn(-c2cccc(Br)c2C=O)c1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US04578402,N#CC(c1ccc(F)cc1)c1cc(Cl)c(N)cc1Cl.O=C=NC(=O)c1c(F)cccc1F>>N#CC(c1ccc(F)cc1)c1cc(Cl)c(NC(=O)NC(=O)c2c(F)cccc2F)cc1Cl,,Cc1ccccc1,,,,val
US20030144249A1,CC(C)(C)[Si](C)(C)OC(CCl)P(C)(C)=O.CN>>CNCC(O[Si](C)(C)C(C)(C)C)P(C)(C)=O,,CO,,,,val
US20060293352A1,CC(C)(C)OC(=O)C(C)(C)Br.COc1cc(F)ccc1O>>COc1cc(F)ccc1OC(C)(C)C(=O)OC(C)(C)C,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20120190665A1,COc1ccc(Cl)cc1-c1nn(C(C)C(=O)OC(C)(C)C)cc1NC(=O)c1n[nH]c2cncnc12>>COc1ccc(Cl)cc1-c1nn(C(C)C(=O)O)cc1NC(=O)c1n[nH]c2cncnc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US05032594,CCCCc1cn2nc3c(c(=O)n(CCC)c(=O)n3Cc3ccccc3)c2[nH]1.CI>>CCCCc1cn2nc3c(c(=O)n(CCC)c(=O)n3Cc3ccccc3)c2n1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100130446A1,CCOC(=O)c1nnc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)s1>>CC(C)(C)[Si](OCc1nnc(CO)s1)(c1ccccc1)c1ccccc1,,CO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20150065522A1,CCOC(=O)C(C)C(=O)c1ccccc1.Nc1[nH]ncc1-c1ccncc1>>Cc1c(-c2ccccc2)[nH]c2c(-c3ccncc3)cnn2c1=O,,CCO,,O=S(=O)(O)O,,val
US04238621,COC(=O)c1ccccc1S(=O)(=O)N=C=O.COc1cc(C)nc(N)n1>>COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(C)cc(OC)n1,,ClCCl,,,,val
US20120309773A1,COc1cccc(N)c1.O=C(O)c1cc(Nc2nc(Cl)nc3ccoc23)n[nH]1>>COc1cccc(NC(=O)c2cc(Nc3nc(Cl)nc4ccoc34)n[nH]2)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090029905A1,Cn1ccc(NC(=O)c2cc(O)cc(O[C@H]3CCOC3)c2)n1.O=C(c1cnc(Cl)c(Cl)c1)N1CCC1>>Cn1ccc(NC(=O)c2cc(Oc3ncc(C(=O)N4CCC4)cc3Cl)cc(O[C@H]3CCOC3)c2)n1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150038437A1,CC(C)(C)OC(=O)c1c(F)ncc(Cl)c1F.II>>CC(C)(C)OC(=O)c1c(F)nc(I)c(Cl)c1F,,C1CCOC1,,[Cl-].[Li+],,val
US20120202691A1,COS(=O)(=O)OC.Cc1cnc(-c2ccc(Cl)cc2)nc1C1C(=O)CCC1=O>>COC1=C(c2nc(-c3ccc(Cl)cc3)ncc2C)C(=O)CC1,,CC(C)=O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US06809110B2,CCOC(=O)C(Cc1ccc(O)c(F)c1)OCC.Cc1sc(-c2ccc(C(C)(C)C)cc2)nc1CCO>>CCOC(=O)C(Cc1ccc(OCCc2nc(-c3ccc(C(C)(C)C)cc3)sc2C)c(F)c1)OCC,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05849920,C#CCO.Nc1nc(F)c(C(F)(F)F)cc1Cl>>C#CCOc1nc(N)c(Cl)cc1C(F)(F)F,,COC(C)(C)C,,[H-].[Na+],,val
US20100099657A2,Cc1ccc(CSC[C@@H](N)C(=O)O)cc1.O=C(O)CNC(=O)COc1ccc([C@@H]2[C@@H](SCC(=O)c3ccc(F)cc3)C(=O)N2c2ccc(F)cc2)cc1>>Cc1ccc(CSC[C@@H](NC(=O)CNC(=O)COc2ccc([C@@H]3[C@@H](SCC(O)c4ccc(F)cc4)C(=O)N3c3ccc(F)cc3)cc2)C(=O)O)cc1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20150133438A1,CC(=O)C(C)O.O=C(NC1=N[C@@]2(c3ccc(F)cc3F)CO[C@@H](C(=O)O)C[C@H]2CS1)c1ccccc1>>CC(=O)C(C)OC(=O)[C@H]1C[C@H]2CSC(NC(=O)c3ccccc3)=N[C@@]2(c2ccc(F)cc2F)CO1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US06350749B1,Cl.N=C(N)NN.O=C1CC(c2ccccc2)Cc2[nH]ccc21>>Cl.N=C(N)NN=C1CC(c2ccccc2)Cc2[nH]ccc21,,CCO,,Cl,O,val
US20150232476A1,CC1(C)CO1.NC(=O)c1c(NC(=O)Nc2ccc(Cl)cc2)sc2c1CCNC2>>CC(C)(O)CN1CCc2c(sc(NC(=O)Nc3ccc(Cl)cc3)c2C(N)=O)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20130035326A1,CC(C)(C)OC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.FC1(F)CCN(CCNc2ccc(Br)cn2)CC1>>CC(C)(C)OC(=O)Nc1ccc(-c2ccc(NCCN3CCC(F)(F)CC3)nc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US07495007B2,C=C(C)C1NC(=O)CC(c2cc(Cl)ccc2OCC(=O)OC)C12C(=O)Nc1cc(Cl)ccc12>>C=C(C)C1NC(=O)CC(c2cc(Cl)ccc2OCC(=O)O)C12C(=O)Nc1cc(Cl)ccc12,,C1CCOC1,,[Na+].[OH-],,val
US04533664,COC(=O)C1=C(O)c2ccccc2S(=O)(=O)N1C.Nc1cncc(Cl)n1>>CN1C(C(=O)Nc2cncc(Cl)n2)=C(O)c2ccccc2S1(=O)=O,,CO,,Cc1ccccc1C,,val
US20080221114A1,C[C@@H]1C[C@H](C)CN(C(=O)[C@@H]2Cc3ccccc3N2)C1.O=[N+]([O-])c1cccnc1Cl>>C[C@@H]1C[C@H](C)CN(C(=O)[C@@H]2Cc3ccccc3N2c2ncccc2[N+](=O)[O-])C1,,Cc1ccccc1,,CCN(CC)CC,,val
US20070149577A1,BrCc1ccccc1.O=Cc1ccc(I)c(O)c1>>O=Cc1ccc(I)c(OCc2ccccc2)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20070191342A1,CCOC(=O)N1CCc2sc3c(c2C(C)C1)CCC3C(F)(F)F>>CC1CNCCc2sc3c(c21)CCC3C(F)(F)F,,ClC(Cl)Cl,,C[Si](C)(C)I,,val
US20140088046A1,N#CCCl.O=C(N[C@H](CF)[C@H](O)c1ccc(-c2cc[nH]c(=O)c2)cc1)C(Cl)Cl>>N#CCn1ccc(-c2ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc2)cc1=O,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160060260A1,CC(C)(C)OC(=O)NCC(=O)O.CC(CO)COc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)cn2)n(C)c(=O)n3C)c1>>CC(COC(=O)CNC(=O)OC(C)(C)C)COc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)cn2)n(C)c(=O)n3C)c1,,CN(C)C=O,,,,val
US20040029932A1,COc1ccc(F)cc1C(C)(C)CC(=O)C(F)(F)F.Cl[Mg]Cc1ccccc1>>COc1ccc(F)cc1C(C)(C)CC(O)(Cc1ccccc1)C(F)(F)F,,C1CCOC1,,,,val
US20110028450A1,CC(C)(C)NCCSCC#Cc1cccs1.CCC(=O)C(=O)Cl.CCOCC>>CCOC(=O)C(=O)N(CCSCC#Cc1cccs1)C(C)(C)C,,CCN(CC)CC,,O,,val
US20090048295A1,CCc1cccc(CC)c1-c1cc(CC)c2c(n1)CCCC2O.O=S(Cl)Cl>>CCc1cccc(CC)c1-c1cc(CC)c2c(n1)CCCC2Cl,,ClCCl,,,,val
US20060142357A1,O=C(O)C12CC[C@H](CC1Br)C2>>O=C(O)C12CCC(CC1)C2,[Zn],CC(=O)O,,,,val
US20120277224A1,CCNc1n[nH]c(N)c1-c1ccccn1.CCOC(=O)CC(=O)c1ccc2c(c1)OCO2>>CCNc1nn2c(=O)cc(-c3ccc4c(c3)OCO4)[nH]c2c1-c1ccccn1,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080045686A1,CCN(CC)C(=S)SCC1(C(=O)O)C=CC=CC1.O=S(Cl)Cl>>CCN(CC)C(=S)SCC1(C(=O)Cl)C=CC=CC1,,ClCCl,,,,val
US20160068482A1,CO.O=C(O)c1ccc(C(=O)c2ccccc2)cc1>>COC(=O)c1ccc(C(=O)c2ccccc2)cc1,O=S(=O)(O)O,,,,,val
US20150315198A1,COc1ccc(OCC2COC2)c(CN)c1F.Clc1ncnc2nn(Cc3ccc(Cn4cccn4)cc3)cc12>>COc1ccc(OCC2COC2)c(CNc2ncnc3nn(Cc4ccc(Cn5cccn5)cc4)cc23)c1F,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20100087427A1,CC(C)c1cccc(O[C@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN(c2ccccc2)c2ccc(Cl)cc2)c1>>CC(C)c1cccc(O[C@H]2CNC[C@@H]2CN(c2ccccc2)c2ccc(Cl)cc2)c1,,C1COCCO1,Cl,,,val
US20080045544A1,CC(C)(C)OC(=O)N1CCC(Nc2ccc(O)cn2)CC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)Oc1ccc(NC2CCN(C(=O)OC(C)(C)C)CC2)nc1,,C1COCCO1,O,Cl,O=C([O-])O.[Na+],val
US20160024121A1,COc1c(CC(NC(=O)CN(C(=O)OCc2ccccc2)C2CCN(C(=O)OC(C)(C)C)CC2)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)OC(C)(C)C>>COc1c(CC(NC(=O)CNC2CCN(C(=O)OC(C)(C)C)CC2)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)OC(C)(C)C,[Pd],CO,,,,val
US05753679,Cc1ccc(C(=O)Cl)cc1.Cc1ccc(CN2CCC(O)CC2)cc1>>Cc1ccc(CN2CCC(OC(=O)c3ccc(C)cc3)CC2)cc1,,Cc1ccccc1,,CCN(CC)CC,,val
US05409936,CC(=O)OC(C)=O.CCCCc1nc2c(n1Cc1ccc(-c3ccccc3C(=O)OC)cc1)C(C(=O)OC)NCC2>>CCCCc1nc2c(n1Cc1ccc(-c3ccccc3C(=O)OC)cc1)C(C(=O)OC)N(C(C)=O)CC2,,c1ccncc1,,,,val
US04380638,CN.CN(C)Cc1nc(CO)cs1.COC1=NS(=O)(=O)N=C1OC.NCCCS>>CNC1=NS(=O)(=O)N=C1NCCCSCc1csc(CN(C)C)n1,,Br,,Cl,,val
US20160222028A1,COC(=O)c1ccc2c(c1)O[C@H](C(C)C)CN(C=O)C2.NO>>CC(C)[C@@H]1CN(C=O)Cc2ccc(C(=O)NO)cc2O1,,C1CCOC1,CO,[Na+].[OH-],,val
US05958931,COc1ccc(C2C(C(C)=O)=C(C)N=C3SC(c4c(Cl)cccc4Cl)=CN32)cc1.Cl>>COc1ccc(C2C(C(C)=O)=C(C)N=C3SC(c4c(Cl)cccc4Cl)=CN32)cc1.Cl,,Cl,,CCOCC,,val
US20040121964A1,C#C[C@H]1CC[C@@H](C#N)N1C(=O)CCl.CC(C)(C)N>>C#C[C@H]1CC[C@@H](C#N)N1C(=O)CNC(C)(C)C,,CC#N,,,,val
US20110003793A1,Clc1cc(I)ccn1.OCc1ncc(Cl)cc1Cl>>Clc1cnc(COc2ccnc(Cl)c2)c(Cl)c1,[Cu]I,Cc1ccccc1,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US20100249119A1,Nc1cccc(O)c1.O=C(Cl)c1cccc(C(F)(F)F)c1>>O=C(Nc1cccc(O)c1)c1cccc(C(F)(F)F)c1,,C1CCOC1,,O,O=C([O-])O.[Na+],val
US20100035871A1,COc1cccc2c1NC(CNC(C)=O)CO2>>CC(=O)NCC1COc2cccc(O)c2N1,,ClCCl,,BrB(Br)Br,,val
US20060241106A1,CCNC(=O)c1noc(-c2cc(CC(C)C)c(OCc3ccccc3)cc2OCc2ccccc2)c1I.O=Cc1ccc(B(O)O)cc1>>CCNC(=O)c1noc(-c2cc(CC(C)C)c(OCc3ccccc3)cc2OCc2ccccc2)c1-c1ccc(C=O)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20050119246A1,CCOC(=O)C(=NOC)C(Cc1ccc(F)cc1)C(C)=O.NN>>CCOC(=O)c1[nH]nc(C)c1Cc1ccc(F)cc1,,CCO,,Cl,,val
US20150259350A1,CN1CCN(C(=O)c2ccc(-c3cnc(N4CCC[C@H](Cn5nnc6ncc(-c7cnn(C)c7)nc65)C4)nc3)cc2)CC1.Cl>>CN1CCN(C(=O)c2ccc(-c3cnc(N4CCC[C@H](Cn5nnc6ncc(-c7cnn(C)c7)nc65)C4)nc3)cc2)CC1.Cl,,C1COCCO1,ClCCl,,,val
US20120115813A1,CC(C)(C)OC(=O)NCCCCOc1cccc2c1B(O)OC2C[N+](=O)[O-].O=C1CCC(=O)N1Cl>>CC(C)(C)OC(=O)NCCCCOc1ccc(Cl)c2c1B(O)OC2C[N+](=O)[O-],,CN(C)C=O,,,,val
US05302724,NS(=O)(=O)c1ccc(Cl)s1.O=C=Nc1ccc(Cl)cc1>>O=C(Nc1ccc(Cl)cc1)NS(=O)(=O)c1ccc(Cl)s1,,CC(C)=O,,Cl,[Na+].[OH-],val
US06514964B1,C=CCBr.Cc1cccc(NC(=O)OC(C)(C)C)n1>>C=CCCc1cccc(NC(=O)OC(C)(C)C)n1,,C1CCOC1,,[Li]CCCC,,val
US20100278733A1,O=C(C=Cc1ccc(Br)cc1)c1ccc([N+](=O)[O-])cc1>>Nc1ccc(C(=O)C=Cc2ccc(Br)cc2)cc1,,CCO,,Cl[Sn]Cl,,val
US20100179161A1,CCOC(=O)CC(C)=O.NNc1ccc([N+](=O)[O-])cn1>>Cc1cc(=O)n(-c2ccc([N+](=O)[O-])cn2)[nH]1,,CCO,,Cl,,val
US20060148888A1,N#CCC1CCOc2cc(S(=O)(=O)c3ccccc3)ccc21>>NCCC1CCOc2cc(S(=O)(=O)c3ccccc3)ccc21,,C1CCOC1,,CN(C)C=O,,val
US20120040020A1,CCC(=O)N1CCC(c2cnc(N)c(C(=O)OC)n2)CC1.NN>>CCC(=O)N1CCC(c2cnc(N)c(C(=O)NN)n2)CC1,,CCO,,O,,val
US20080045534A1,Cc1ccc(N)c(C)c1NC(=O)CCC1CCCC1.O=Cc1ccc(F)cc1>>Cc1ccc(NCc2ccc(F)cc2)c(C)c1NC(=O)CCC1CCCC1,,C1CCOC1,,CO,[BH4-].[Na+],val
US20050267096A1,CC(=O)n1cc2c(Br)cccc2n1>>Brc1cccc2[nH]ncc12,,Cl,,,,val
US20080280875A1,CCOC(=O)c1cc(Oc2ccc(S(C)(=O)=O)cc2)c2cc(C)oc2c1.O=C1CCC(=O)N1Br>>CCOC(=O)c1cc(Oc2ccc(S(C)(=O)=O)cc2)c2cc(CBr)oc2c1,,ClC(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20070249657A1,Cc1ccc(-c2ccc(Cl)nn2)c(F)c1.OC1CCN2CCCC1C2>>Cc1ccc(-c2ccc(OC3CCN4CCCC3C4)nn2)c(F)c1,,CN(C)C=O,,[H-].[Na+],,val
US20110098297A1,COCCOc1c(F)c(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C(N)=O)[nH]c12.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COCCOc1c(F)c(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C(N)=S)[nH]c12,,C1CCOC1,,,,val
US09249179B2,CC(=O)N[C@H]1[C@H](OCCOCCOCCOCC(=O)OCc2ccccc2)O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O,[Pd],CCOC(C)=O,,,,val
US04377580,CCOC=C(C(=O)OCC)C(=O)OCC.Nc1ncnc2ccc(NC(=O)CCC3CCCC3)cc12>>CCOC(=O)c1cnc2c3cc(NC(=O)CCC4CCCC4)ccc3ncn2c1=O,,CN(C)C=O,,O,,val
US20070190359A1,N#Cc1ccccc1-n1cnc2ccccc21.O=C1CCC(=O)N1Br>>N#Cc1ccccc1-n1c(Br)nc2ccccc21,,C1COCCO1,,O,,val
US20140094472A1,CC(C)(C)C(=O)Cl.O=c1ccc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2[nH]1>>CC(C)(C)C(=O)Oc1ccc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2n1,,ClCCl,,c1ccncc1,,val
US05889026,Cc1ccc(CC2(O)CCN(CCN(C)C(=O)c3ccc(OCc4ccccc4)cc3)CC2)cc1>>Cc1ccc(CC2(O)CCN(CCN(C)C(=O)c3ccc(O)cc3)CC2)cc1,[Pd],CC(=O)O,,,,val
US20090029965A1,COC(=O)c1ccc(CC(=O)N2CCN(CC3CCC3)CC2)c(C)c1>>Cc1cc(C(=O)O)ccc1CC(=O)N1CCN(CC2CCC2)CC1,,C1CCOC1,O,[Li+].[OH-],,val
US06110962,CC(C)(C)OP(=O)(Oc1c(Br)cc(-c2c3ccccc3c(Br)c3sc4ccccc4c23)cc1Br)OC(C)(C)C>>O=P(O)(O)Oc1c(Br)cc(-c2c3ccccc3c(Br)c3sc4ccccc4c23)cc1Br,,C1COCCO1,,Cl,,val
US20100009982A1,N#Cc1ccc(OCc2ccccc2)c(C(=O)OCc2ccccc2)c1.[N-]=[N+]=[N-]>>O=C(OCc1ccccc1)c1cc(-c2nnn[nH]2)ccc1OCc1ccccc1,,CN(C)C=O,,[Cl-].[NH4+],,val
US04775671,O=C(O)c1ncn2c1[C@@H]1CCN1C(=O)c1c-2cccc1C(F)(F)F.O=C(n1ccnc1)n1ccnc1>>O=C1c2c(cccc2C(F)(F)F)-n2cnc(C(=O)n3ccnc3)c2[C@@H]2CCN12,,CN(C)C=O,,O,,val
US20140162076A1,O=[N+]([O-])c1ccc(CCCCCO)c([N+](=O)[O-])c1.O=c1ccc2ccc(O)cc2o1>>O=c1ccc2ccc(OCCCCCc3ccc([N+](=O)[O-])cc3[N+](=O)[O-])cc2o1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160264522A1,CC1CC(C(=O)O)CN1C(=O)OC(C)(C)C.Cc1cc(N)ccc1F>>Cc1cc(NC(=O)C2CC(C)N(C(=O)OC(C)(C)C)C2)ccc1F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140256734A1,CC(C)(C)OC(=O)N1CC[C@H](Oc2nc(C(=N)NN)cc3cccc(Cl)c23)C1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)N1CC[C@H](Oc2nc(-c3n[nH]c(=O)[nH]3)cc3cccc(Cl)c23)C1,,C1COCCO1,,,,val
US20040220169A1,CNC(C)C.O=C(NCc1nc2cc(Cl)ccc2[nH]1)c1ccc(C(=O)O)c(Cl)c1>>CC(C)N(C)C(=O)c1ccc(C(=O)NCc2nc3cc(Cl)ccc3[nH]2)cc1Cl,,CS(C)=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20020103229A1,CC(=O)c1ccc2c(c1)c(-c1ccc(F)cc1)nn2C1CCCCO1>>CC(=O)c1ccc2[nH]nc(-c3ccc(F)cc3)c2c1,,CO,,Cl,,val
US20100125058A1,CB(O)O.CCS(=O)(=O)c1ccc(Oc2cc(CC(=O)OC)cc3ccc(Br)cc23)nc1>>CCS(=O)(=O)c1ccc(Oc2cc(CC(=O)OC)cc3ccc(C)cc23)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,Cc1ccccc1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20080085886A1,Cc1ccc(S(=O)(=O)n2ccnc2CO)cc1.O=C1c2ccccc2C(=O)N1O>>Cc1ccc(S(=O)(=O)n2ccnc2CON2C(=O)c3ccccc3C2=O)cc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06420409B1,CCCC(CS(=O)(=O)NC(C)(C)C)OC(=O)c1ccccc1>>CCCC(CS(N)(=O)=O)OC(=O)c1ccccc1,,CCOC(C)=O,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20150284337A1,CC(C)Nc1c(C(N)=O)nnc2cc(I)ccc12.CS(=O)(=O)c1ccc(B(O)O)cc1>>CC(C)Nc1c(C(N)=O)nnc2cc(-c3ccc(S(C)(=O)=O)cc3)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US06046192,C1=COCCC1.O=C(CBr)c1ccc(O)cc1>>O=C(CBr)c1ccc(OC2CCCCO2)cc1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US06627647B1,CC(C)(C)OC(=O)CN.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)CNc1ccc([N+](=O)[O-])cc1,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20070197558A1,CCSc1ncc(C#N)c(N)n1.COC(OC)N(C)C>>CCSc1ncc(C#N)c(N=CN(C)C)n1,,Cc1ccccc1,,,,val
US20130172554A1,O=C1COCCN1c1ccc(NCC(O)CCl)cc1.O=C1NC(=O)c2ccccc21>>O=C1NC(=O)c2c(CC(O)CNc3ccc(N4CCOCC4=O)cc3)cccc21,,CN(C)C=O,,,,val
US20090124596A1,N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3cccc(-c4ccc(OCCO)cc4)c3)c2=O)CC1.O=C(O)c1cn2cc(F)ccc2n1>>O=C(N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3cccc(-c4ccc(OCCO)cc4)c3)c2=O)CC1)c1cn2cc(F)ccc2n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20010031780A1,CC(C)(C)OC(=O)N[C@H](C(=O)N1CC=C[C@H]1C(N)=O)C(C)(C)C>>CC(C)(C)OC(=O)N[C@H](C(=O)N1CC=C[C@H]1C#N)C(C)(C)C,,c1ccncc1,,O=P(Cl)(Cl)Cl,,val
US06518257B1,BrCc1ccccc1.Oc1ccc(Br)cc1-c1ccc(F)cc1>>Fc1ccc(-c2cc(Br)ccc2OCc2ccccc2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090143371A1,CB1OB(C)OB(C)O1.Cc1onc(-c2ccccc2)c1COc1ncc(C(=O)NC2CCOCC2)cc1Br>>Cc1cc(C(=O)NC2CCOCC2)cnc1OCc1c(-c2ccccc2)noc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20090023781A1,CCOC(=O)C(F)(F)Br.Oc1ccc(F)cc1>>CCOC(=O)C(F)(F)Oc1ccc(F)cc1,,CCOCC,,[H-].[Na+],,val
US20130324546A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CCNCC3)cc2F)ncc1C(F)(F)F>>COC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CCN(C(=O)OC(C)(C)C)CC3)cc2F)ncc1C(F)(F)F,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20160031876A1,COC(=O)[C@@]1(c2ccc(F)c(F)c2C)CC[C@H](O)C1>>COC(=O)[C@@]1(c2ccc(F)c(F)c2C)CCC(=O)C1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090247608A1,COC(=O)CCC(C(=O)OC(C)(C)C)N(Cc1cnc2nc(NC(=O)C(C)C)[nH]c(=O)c2n1)C(=O)C(F)(F)F>>COC(=O)CCC(C(=O)O)N(Cc1cnc2nc(NC(=O)C(C)C)[nH]c(=O)c2n1)C(=O)C(F)(F)F,,ClCCl,O=C(O)C(F)(F)F,,,val
US05587480,O=CCOC(=O)c1ccccc1.SCCS>>O=C(OCC1SCCS1)c1ccccc1,,Cc1ccccc1,,,,val
US20030060460A1,Nc1ccc(Cl)cc1[N+](=O)[O-].O=S(=O)(Cl)c1ccccc1>>O=[N+]([O-])c1cc(Cl)ccc1NS(=O)(=O)c1ccccc1,,ClCCl,,O,c1ccncc1,val
US05124350,C=CCc1c(OCCCOc2cccc(OCC(=O)OCC)c2CCC)ccc(C(N)=O)c1OC>>C=CCc1c(OCCCOc2cccc(OCC(=O)O)c2CCC)ccc(C(N)=O)c1OC,,CO,,[Li+].[OH-],,val
US20130131017A1,COC(=O)c1ccc(CO)n2cccc12>>COC(=O)c1ccc(C=O)n2cccc12,O=[Mn]=O,ClCCl,,,,val
US20130196002A1,COc1ccc(CCl)cc1.Cn1c(Cl)ncc(O)c1=O>>COc1ccc(COc2cnc(Cl)n(C)c2=O)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06218501B1,Nc1ccccc1O.O=C1C=CC(=O)O1.c1ccc2cnccc2c1>>O=C1C=C(c2ccccc2)C(=O)N1,,O,,Cc1ccccc1C,,val
US04039670,Cc1cc(F)ccc1C1(CCCCl)OCCO1.O=C1NCN(c2ccccc2)C12CCNCC2>>Cc1cc(F)ccc1C1(CCCN2CCC3(CC2)C(=O)NCN3c2ccccc2)OCCO1,,CN(C)C=O,,[I-].[K+],,val
US04740612,COC(=O)C1C(CC(Cl)(Cl)Cl)C1(C)C>>CC1(C)C(C=C(Cl)Cl)C1C(=O)O,,O,,CO,[Na+].[OH-],val
US20040256616A1,C1CCOC1.CCCCCCCC[Mg]Br.CCOCC.CSC(SC)=C1c2cc(Br)ccc2-c2ccc(Br)cc21>>CCCCCCCCC(CCCCCCCC)=C1c2cc(Br)ccc2-c2ccc(Br)cc21,,C1CCOC1,CCOCC,,,val
US20080015199A1,COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(OC)c2c(c1)OCCCO2.NNc1ncccc1F>>COc1cc(C(Nc2ccc(-c3noc(C)n3)cc2)c2nn(-c3ncccc3F)c(=O)[nH]2)cc2c1OCCCO2,,CN(C)C=O,,CCN(CC)CC,,val
US20120329818A1,Cc1c[nH]c2ncnc(Cl)c12.O=C(O)C1(c2ccccc2)CCNCC1>>Cc1c[nH]c2c1C(N1CCC(C(=O)O)(c3ccccc3)CC1)NC=N2,,CC(C)O,,CCN(CC)CC,,val
US04806538,CC(=O)OC(C)=O.Cn1cc(C[C@H]2NC(=O)[C@@H](CCCN)NC2=O)c2ccccc21>>CC(=O)NCCC[C@H]1NC(=O)[C@@H](Cc2cn(C)c3ccccc23)NC1=O,,c1ccncc1,,,,val
US20020133023A1,CCOC(=O)C(C#N)=C(C)c1cccnc1.N#CCC(N)=O>>CC1(c2cccnc2)C(C#N)C(=O)NC(=O)C1C#N,,CCO,,C,C[O-].[Na+],val
US20030134827A1,BrCc1ccccc1.COC(=O)CN(C(=O)OC(C)(C)C)c1ccc(O)cc1>>COC(=O)CN(C(=O)OC(C)(C)C)c1ccc(OCc2ccccc2)cc1,,CCOC(C)=O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20140336190A1,CNc1c(C(=O)OC)cc(Br)cc1[N+](=O)[O-].Cc1noc(C)c1B1OC(C)(C)C(C)(C)O1>>CNc1c(C(=O)OC)cc(-c2c(C)noc2C)cc1[N+](=O)[O-],,CCOC(C)=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060135517A1,Cc1cccc(-c2nc3ccccn3c2-c2ccnc(C#N)n2)n1.[N-]=[N+]=[N-]>>Cc1cccc(-c2nc3ccccn3c2-c2ccnc(-c3nnn[nH]3)n2)n1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20150133512A1,CCC#CC(=O)OCC.[N-]=[N+]=Nc1ccc(Br)cc1>>CCOC(=O)c1c(CC)nnn1-c1ccc(Br)cc1,,Cc1ccccc1,,,,val
US04092150,CC(C)Nc1nc(Cl)c(C#N)c(NC(C)C)n1.CO>>COc1nc(NC(C)C)nc(NC(C)C)c1C#N,,CO,,C[O-].[Na+],,val
US20110076291A1,CC(C)(C)OC(=O)N1CCNCC1.CN(C(=O)c1cc2c(s1)-c1ccc(Br)cc1OCC2)c1cc(C(=O)O)ccc1Cl>>CN(C(=O)c1cc2c(s1)-c1ccc(Br)cc1OCC2)c1cc(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)ccc1Cl,,C1CCOC1,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06222073B1,CC=Cc1ccccc1.Nc1ccccc1>>CC(Cc1ccccc1)Nc1ccccc1,,CCCCCC,CCOC(C)=O,,,val
US20160251456A1,Cc1cc(C)c(Cn2ccnc2C)c(C)c1C=NO>>Cc1cc(C)c(Cn2ccnc2C)c(C)c1C#[N+][O-],,ClCCl,,[Na+].[O-]Cl,,val
US20130102776A1,COc1ccc2c(c1/C=C\CCC1CCN(C(=O)OC(C)(C)C)CC1)O/C(=C\c1n[nH]c3ccccc13)C2=O>>COc1ccc2c(c1/C=C\CCC1CCNCC1)O/C(=C\c1n[nH]c3ccccc13)C2=O,,C1COCCO1,ClCCl,Cl,,val
US20160222014A1,C[C@@H]1CNCCN1C(=O)OC(C)(C)C.O=[N+]([O-])c1ccc(F)cc1>>C[C@@H]1CN(c2ccc([N+](=O)[O-])cc2)CCN1C(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080045556A1,CC(C)(CO)Nc1nc(-c2ccc(Br)cc2F)cs1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC1(C)COC(=O)N1c1nc(-c2ccc(Br)cc2F)cs1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080009515A1,CCOC(=O)c1cnc(Cl)c2c(COc3cccc(-c4nnn(C)n4)c3)csc12.N>>CCOC(=O)c1cnc(N)c2c(COc3cccc(-c4nnn(C)n4)c3)csc12,,CC(C)O,,,,val
US20120329848A1,CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C(F)(F)F.N=C(N)NCCC[C@H](N)C(=O)O>>CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C(F)(F)F.N=C(N)NCCC[C@H](N)C(=O)O,,CC(C)=O,,O,,val
US05840732,CCCC=C1SC(=O)N(CCCCOc2cccn3c(C(=O)C(F)(F)F)cnc23)C1=O.Cl>>CCCC=C1SC(=O)N(CCCCOc2cccn3c(C(=O)C(F)(F)F)cnc23)C1=O.Cl,,CO,,,,val
US20080255111A1,C#Cc1ccc(CO[Si](C)(C)C(C)(C)C)cc1OCOC>>CCc1ccc(CO[Si](C)(C)C(C)(C)C)cc1OCOC,,CO,,,,val
US06066633,CC(C)(C)OC(=O)Cn1cc(C[C@@H](NC(=O)OCc2ccccc2)C(=O)O)c2ccccc21>>CC(C)(C)OC(=O)Cn1cc(C[C@@H](N)C(=O)O)c2ccccc21,[Pd],CO,,,,val
US20110105436A1,Cc1cc(C(=O)CBr)ccn1.Cc1cccc(NC(N)=S)c1>>Cc1cccc(Nc2nc(-c3ccnc(C)c3)cs2)c1,,CCO,O,N,,val
US20100009970A1,CI.NS(=O)(=O)c1ccc(F)c(C(=O)O)c1>>COC(=O)c1cc(S(N)(=O)=O)ccc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130261101A1,CC(O)c1cc(Cl)c(C#N)c2c1OCCN=C2>>CC(O)c1cc(Cl)c(C#N)c2c1OCCNC2,,CCO,,O,[BH4-].[Na+],val
US20060052447A1,CCOC(=O)/C=C(/CP(=O)(OCC)OCC)c1ccccc1.COc1ccc(OC)c(C(=O)C=O)c1>>CCOC(=O)/C=C(/C=C/C(=O)c1cc(OC)ccc1OC)c1ccccc1,,C1CCOC1,,O,CC(C)(C)[O-].[K+],val
US20150210720A1,COCCOc1nc(N2CCN(C(C)=O)CC2)ccc1[N+](=O)[O-]>>COCCOc1nc(N2CCN(C(C)=O)CC2)ccc1N,[Ni],O,,C1CCOC1,,val
US06395733B1,C#Cc1cccc(N)c1.Clc1ncnc2[nH]ccc12>>C#Cc1cccc(Nc2ncnc3[nH]ccc23)c1.Cl,,c1ccncc1,,,,val
US05936102,COc1ccccc1O.FC(F)(Br)C(F)(F)Br>>COc1ccccc1OC(F)(F)C(F)(F)Br,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140309207A1,CC(C)(C)OC(=O)N1CCC2(CNc3ccc(Br)cc32)C1.O=C(Nc1ncc(Cl)s1)Oc1ccc([N+](=O)[O-])cc1>>CC(C)(C)OC(=O)N1CCC2(C1)CN(C(=O)Nc1ncc(Cl)s1)c1ccc(Br)cc12,,CN(C)C=O,O,CCN(CC)CC,,val
US05322853,Nc1cc(Cl)c(Cl)cc1[N+](=O)[O-].Oc1cccc(Cl)c1Cl>>Nc1cc(Oc2cccc(Cl)c2Cl)c(Cl)cc1[N+](=O)[O-],,O,,[K+].[OH-],,val
US20120122900A1,Cc1cccc(-c2cc([N+](=O)[O-])c(=O)n(CC(F)(F)F)c2C)c1F>>Cc1cccc([C@@H]2C[C@H](N)C(=O)N(CC(F)(F)F)[C@@H]2C)c1F,O=[Pt]=O,CO,,Cl,[H][H],val
US20150266881A1,CC(C)(C)OC(=O)NC1CC1c1ccc(F)c(C(=O)O)c1.Cn1cc(N)cn1>>Cn1cc(NC(=O)c2cc([C@@H]3C[C@H]3NC(=O)OC(C)(C)C)ccc2F)cn1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070276000A1,COCc1cc2ccccc2c(O)c1-c1ccccc1.O=Cc1ccc(F)cc1>>COCc1cc2ccccc2c(Oc2ccc(C=O)cc2)c1-c1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130150344A1,COc1cn(-c2ccc(-n3cc(F)c(F)c3)cc2OCc2ccccc2)nc(-c2ccnn2-c2ccccc2)c1=O>>COc1cn(-c2ccc(-n3cc(F)c(F)c3)cc2O)nc(-c2ccnn2-c2ccccc2)c1=O,[Pd],CC(=O)O,,,,val
US20060281751A1,CN(C)C=O.O=Cc1ccc(OCC(=O)O)cc1>>CNC(=O)COc1ccc(C=O)cc1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20050227990A1,C1=COCCC1.CC(=O)c1ccc(O)cc1F>>CC(=O)c1ccc(OC2CCCCO2)cc1F,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US04842638,CCC(=O)Cl.O=C1CC(=O)C(C2CCCSC2)CO1>>CCC(=O)C1C(=O)OCC(C2CCCSC2)C1=O,,C1CCOC1,O,CCN(CC)CC,,val
US04254134,CC(=O)NC1CCCC(=O)C1.NNc1ccccc1>>CC(=O)NC1CCc2c([nH]c3ccccc23)C1,,CC(=O)O,,O,,val
US20140213586A1,CN(C)C=O.ClCCl.Fc1cccc2[nH]ccc12>>O=Cc1c[nH]c2cccc(F)c12,,ClCCl,,O=P(Cl)(Cl)Cl,O=C([O-])O.[Na+],val
US20070179143A1,CCOC(=O)c1cccc(C(=O)OCC)c1>>CCOC(=O)c1cccc(CO)c1,,C1CCOC1,,O,[BH4-].[Li+],val
US20130225588A1,COC(=O)Cc1cc2ccc(Cl)cc2c(B2OC(C)(C)C(C)(C)O2)c1C.Clc1ccccc1Sc1ccc(Br)cc1>>COC(=O)Cc1cc2ccc(Cl)cc2c(-c2ccc(Sc3ccccc3Cl)cc2)c1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])O.[Na+],val
US20090023753A1,COC(=O)c1scnc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)Nc1ncsc1C(=O)O,,C1CCOC1,CCO,[Na+].[OH-],,val
US05427779,COc1c2occc2cc2ccc(=O)oc12>>O=c1ccc2cc3ccoc3c(O)c2o1,,c1ccccc1,,[Mg],,val
US20090143372A1,CCCN.CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(C=O)c4)cc23)CC1>>CCCNCc1cccc(-c2cc(C(N)=O)c3[nH]cc(C4CCN(S(=O)(=O)CC)CC4)c3c2)c1,CC(=O)O,CO,ClCCl,[BH4-].[Na+],,val
US20150336986A1,O=C1CC(CO)CO1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C1CC(COS(=O)(=O)C(F)(F)F)CO1,,ClCCl,,Cc1cccc(C)n1,,val
US04596823,Cc1ccc(S(=O)(=O)OC[C@@H]2CC=CC[C@@H]2COCc2ccccc2)cc1.[C-]#N>>N#CC[C@@H]1CC=CC[C@@H]1COCc1ccccc1,,CS(C)=O,,O,,val
US20120172382A1,Nc1nccc(Oc2cc(F)ccc2F)c1I.O=[N+]([O-])O>>Nc1nccc(Oc2cc(F)c([N+](=O)[O-])cc2F)c1I,,O=S(=O)(O)O,,O=C([O-])O.[Na+],,val
US04198412,ClCCl.Nc1ccccc1-c1cc(C(=O)O)n[nH]1.O=C(OC(=O)c1ccccc1)c1ccccc1>>COC(=O)c1cc2c3ccccc3nc(-c3ccccc3)n2n1,,O,,O=C([O-])O.[Na+],,val
US20100249119A1,CC(C)(C#N)c1cccc(C(=O)Nc2cc(Oc3ccc4nc(N)sc4n3)c(Cl)cc2F)c1.O=C(Cl)C1CC1>>CC(C)(C#N)c1cccc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)sc4n3)c(Cl)cc2F)c1,,CCOC(C)=O,c1ccncc1,,,val
US20100286126A1,CCC(=O)N[C@H]1C[C@@H](n2cnc3c(NC(c4ccc(OC)cc4)c4ccc(OC)cc4)nc(-n4cc(C(=O)NC)cn4)nc32)[C@H](O)[C@@H]1O>>CCC(=O)N[C@H]1C[C@@H](n2cnc3c(N)nc(-n4cc(C(=O)NC)cn4)nc32)[C@H](O)[C@@H]1O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070032489A1,CCc1cc(-c2cccs2)c(C)[nH]c1=O.O=Cc1ccccn1>>CCc1cc(-c2ccc(C(O)c3ccccn3)s2)c(C)[nH]c1=O,,C1CCOC1,,[Li]CCCC,,val
US20120083469A1,C=CCCC(NC(=O)OC(C)(C)C)(C(=O)OCC)C(=O)OCC>>C=CCCC(NC(=O)OC(C)(C)C)(C(=O)O)C(=O)OCC,,CCO,,[Na+].[OH-],,val
US20120329818A1,CC1(C(=O)Nc2cccc(Oc3ccc(F)cc3)c2)CCNCC1.Clc1ncnc2[nH]cc(Br)c12>>CC1(C(=O)Nc2cccc(Oc3ccc(F)cc3)c2)CCN(c2ncnc3[nH]cc(Br)c23)CC1,,CC(C)O,,CCN(CC)CC,,val
US20160168158A1,CC(=O)OC(C)(C)C(=O)Cl.NC(=O)c1nnn(Cc2ccccc2Cl)c1N>>CC(C)(O)c1nc2c(nnn2Cc2ccccc2Cl)c(=O)[nH]1,,c1ccncc1,,O,,val
US05254655,C=CCCBr.O=[N+]([O-])c1ccc(F)cc1O>>CCC=COc1cc([N+](=O)[O-])ccc1F,,CC(C)=O,O,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US20100249105A1,CC1(C)OC(=O)C(=CNc2ccc(Br)cn2)C(=O)O1>>O=c1ccnc2ccc(Br)cn12,,c1ccc(Oc2ccccc2)cc1,,,,val
US20070032478A1,CC(=O)Nc1ccc(C(=O)c2ccc3c(c2)NC(=O)C3=CO)cc1.Nc1cccc(O)c1>>CC(=O)Nc1ccc(C(=O)c2ccc3c(c2)NC(=O)C3=CNc2cccc(O)c2)cc1,,C1CCOC1,,,,val
US20070208046A1,C1=COCCC1.O=c1c(Br)c(Br)cnn1-c1ccc(O)cc1>>O=c1c(Br)c(Br)cnn1-c1ccc(OC2CCCCO2)cc1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US05236952,COc1cc(C(=O)c2cccnc2)ccc1O.O=[N+]([O-])O>>COc1cc(C(=O)c2cccnc2)cc([N+](=O)[O-])c1O,,CC(=O)O,,N,,val
US20020119992A1,CC(C)(C)OC(=O)NCc1ccc(Cl)cc1CO.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)NCc1ccc(Cl)cc1CN,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20040198755A1,CS(=O)(=O)Cl.OCCc1ccc2c(c1)OCO2>>CS(=O)(=O)OCCc1ccc2c(c1)OCO2,,ClCCl,,CCN(CC)CC,,val
US05859044,CCOC(=O)c1cc2cc(CC3(C)OCCO3)ccc2n1Cc1ccc(NS(=O)(=O)CC(F)(F)F)cc1>>CCOC(=O)c1cc2cc(CC(C)=O)ccc2n1Cc1ccc(NS(=O)(=O)CC(F)(F)F)cc1,,CC(C)=O,,O=S(=O)(O)O,,val
US05094938,CCCCCCCCCCCCS(=O)(=O)c1ccccc1C(=O)O.O=C(Cl)C(=O)Cl>>CCCCCCCCCCCCS(=O)(=O)c1ccccc1C(=O)Cl,,ClCCl,,CN(C)C=O,,val
US20150336986A1,C=CCC(c1nc(Cl)cs1)c1[nH]c(-c2cccc(F)c2)c2c(=O)n(C)c(=O)n(C)c12.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>Cn1c(=O)c2c(-c3cccc(F)c3)[nH]c(C(CC(O)CO)c3nc(Cl)cs3)c2n(C)c1=O,O=[Os](=O)(=O)=O,CC#N,,O,,val
US20050187266A1,O=C(Cl)C1CCCO1.O=C1N[C@@H](Cc2ccccc2)CO1>>O=C1OC[C@H](Cc2ccccc2)N1C(=O)C1CCCO1,,C1CCOC1,,[Li]CCCC,,val
US20120184524A1,Brc1cccc(-c2n[nH]c3ncccc23)n1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>Brc1cccc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3ncccc23)n1,,CN(C)C=O,,[H-].[Na+],,val
US04948809,CCOC(=O)CCC(=O)c1ccc(CCNS(=O)(=O)c2cccc(Cl)c2)cc1>>O=C(O)CCC(=O)c1ccc(CCNS(=O)(=O)c2cccc(Cl)c2)cc1,,CO,,[Na+].[OH-],,val
US20110190269A1,CC(C)(O)c1ccc(Br)c2nc(N)nn12.OB(O)c1ccc(Cl)cc1>>CC(C)(O)c1ccc(-c2ccc(Cl)cc2)c2nc(N)nn12,,C1COCCO1,O,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20150141419A1,CCOC(=O)Cc1cccs1>>O=C(O)Cc1cccs1,,CCO,,Cl,[Na+].[OH-],val
US20160060273A1,CCOC(=O)C1(C)CCN(C2=NOC3(C2)CN(Cc2cc(OCC)c(-c4ccc(F)cc4)c(C4CC4)c2)C3)CC1>>CCOc1cc(CN2CC3(CC(N4CCC(C)(C(=O)O)CC4)=NO3)C2)cc(C2CC2)c1-c1ccc(F)cc1,,CCO,,Cl,[Na+].[OH-],val
US05789406,Nc1ccc2c(c1)Cc1c-2[nH]c(=O)c2nccn12.O=C=Nc1ccccc1F>>O=C(Nc1ccc2c(c1)Cc1c-2[nH]c(=O)c2nccn12)Nc1ccccc1F,,CCN(CC)CC,,CN(C)C=O,Cl,val
US20020119983A1,COc1ccc(-c2cc(CCC=O)on2)cc1OC.c1ccc(CN2CCNCC2)cc1>>COc1ccc(-c2cc(CCCN3CCN(Cc4ccccc4)CC3)on2)cc1OC,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070244086A1,Cn1ncc(Br)c1-c1cc(N)ccc1OCCN1CCCC1.O=C(Cl)c1cccc(F)c1>>Cn1ncc(Br)c1-c1cc(NC(=O)c2cccc(F)c2)ccc1OCCN1CCCC1,,ClCCl,,CCN(CC)CC,,val
US04814343,CC1(C)OCc2cc(C(O)c3c[nH]cn3)ccc2O1>>CC1(C)OCc2cc(Cc3c[nH]cn3)ccc2O1,[Pd],CO,,,,val
US20070027178A1,Cl.NNc1cc(Cl)ccc1Br.O=C1CCNCC1>>Cl.Clc1ccc(Br)c(NN=C2CCNCC2)c1,,CCO,,Cl,O,val
US20090156572A1,COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1.Cl>>COc1ccc(C(=O)N(C)[C@@H]2CCNC[C@H]2c2ccc(Cl)c(Cl)c2)cc1.Cl,,CCOC(C)=O,,,,val
US20150203493A1,COC(=O)C1CC2CCC(C1)N2Cc1ccc2c(O[C@@H]3CC[C@@H](C(C)(C)C)CC3)cccc2c1>>CC(C)(C)[C@@H]1CC[C@@H](Oc2cccc3cc(CN4C5CCC4CC(C(=O)O)C5)ccc23)CC1,,CO,,[Na+].[OH-],,val
US20060084663A1,COC(=O)c1sc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)nc1C>>Cc1nc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)sc1CO,,C1CCOC1,C1CCOC1,[Li],,val
US04609669,ClCl.Oc1ccc(OC(F)(F)F)cc1>>Oc1ccc(OC(F)(F)F)cc1Cl,,ClC(Cl)(Cl)Cl,,,,val
US20010045393A1,NC(N)=O.O=S(=O)(O)O>>NC(N)=O.O=S(=O)(O)O,,O,,[Na+].[OH-],,val
US20050222408A1,O=C(Cl)c1ccc([N+](=O)[O-])o1.c1ccc(N2CCNCC2)cc1>>O=C(c1ccc([N+](=O)[O-])o1)N1CCN(c2ccccc2)CC1,,CCN(CC)CC,ClCCl,,,val
US20110071115A1,O=C1CC(=P(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)N1.O=Cc1cnn2c(NCC3CC3)cc(Cl)nc12>>O=C1CC(=Cc2cnn3c(NCC4CC4)cc(Cl)nc23)C(=O)N1,,CO,,,,val
US20140228343A1,Brc1ccc2ncn(C3CCNCC3)c2c1.CC(=O)Cl>>CC(=O)N1CCC(n2cnc3ccc(Br)cc32)CC1,,ClCCl,c1ccncc1,,,val
US20050222410A1,CC(C)(C)OC(=O)Nc1ccccc1N.O=C(O)c1ccc(Br)nc1>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(Br)nc1,,CN(C)C=O,,O,,val
US04067720,CN=C=O.Oc1nsc(-c2ccccc2)n1>>CNC(=O)n1sc(-c2ccccc2)nc1=O,,C1CCOC1,,CCN(CC)CC,,val
US20040044052A1,O=C1CCc2cccc(F)c2N1.O=[N+]([O-])O>>O=C1CCc2cc([N+](=O)[O-])cc(F)c2N1,,O=S(=O)(O)O,,,,val
US04472310,CC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H]([C@@H]5C[C@@H]5C45OCCO5)[C@@H]3[C@@H](O)[C@H]3O[C@]32C1.ClC(Cl)(Cl)Cl>>CC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@H]([C@@H]3[C@H](Cl)[C@H]3O[C@]32C1)[C@@H]1C[C@@H]1C41OCCO1,,ClCCl,c1ccncc1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160222047A1,CCc1ccc(C2(OC)O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)cc1Cc1ccc2c(c1)OCCO2>>CCc1ccc(C2(OC)O[C@H](CO)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)cc1Cc1ccc2c(c1)OCCO2,,CO,,CC(=O)Cl,,val
US20120295900A1,COc1ccc(C(NC2=N[C@](C)(c3cc(B4OCC(C)(C)CO4)c(F)cc3F)C(F)(F)CO2)(c2ccccc2)c2ccc(OC)cc2)cc1.Clc1ccc2nc(Cl)oc2c1>>COc1ccc(C(NC2=N[C@](C)(c3cc(-c4nc5ccc(Cl)cc5o4)c(F)cc3F)C(F)(F)CO2)(c2ccccc2)c2ccc(OC)cc2)cc1,,C1CCOC1,O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],val
US20060241115A1,Nc1cccc2cc(Oc3ccnc4[nH]ncc34)ccc12.O=C(O)c1ccc(Cl)cc1>>O=C(Nc1cccc2cc(Oc3ccnc4[nH]ncc34)ccc12)c1ccc(Cl)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20030100554A1,CCc1nn(CC(=O)OC)c(CC)c1Oc1cc(Cl)cc(Cl)c1.NN>>CCc1nn(CC(=O)NN)c(CC)c1Oc1cc(Cl)cc(Cl)c1,,CCO,,O,,val
US20070099915A1,C[Si](C)(C)CCOCON1CCc2c(ncc3c2c(CC=O)cn3Cc2ccc(F)cc2)C1=O>>C[Si](C)(C)CCOCON1CCc2c(ncc3c2c(CCO)cn3Cc2ccc(F)cc2)C1=O,,CO,,[BH4-].[Na+],,val
US20060128734A1,C1CCNCC1.O=C(Nc1ccc(CBr)c(C(F)(F)F)c1)C(F)(F)F>>O=C(Nc1ccc(CN2CCCCC2)c(C(F)(F)F)c1)C(F)(F)F,,CC#N,O,,,val
US20100035942A1,O=[N+]([O-])c1c(F)c(F)cc(F)c1OCc1ccccc1>>Nc1c(F)c(F)cc(F)c1OCc1ccccc1,[Zn],O,,CCO,[Cl-].[NH4+],val
US20140206673A1,CC1(C)CC(=O)CCO1.O=C(Cl)C1CC1>>CC1(C)CC(=O)C(C(=O)C2CC2)CO1,,Cc1ccccc1,,CC(C)[N-]C(C)C.[Li+],,val
US20100087427A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2O)C(C)C)ccc1OC.COc1cccc(CCl)c1OC>>COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2OCc2cccc(OC)c2OC)C(C)C)ccc1OC,,O,,CC#N,CC#N,val
US20150203515A1,COC(=O)c1ccc2cc(O)ccc2c1.CS(=O)(=O)O[C@H]1CC[C@@H](C(F)(F)F)CC1>>COC(=O)c1ccc2cc(O[C@H]3CC[C@@H](C(F)(F)F)CC3)ccc2c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110112087A1,CCN(C(=O)OC(C)(C)C)c1ccc(C(=O)OC)cn1>>CCN(C(=O)OC(C)(C)C)c1ccc(C(=O)O)cn1,,C1COCCO1,O,[Li+].[OH-],,val
US20080269211A1,BrCc1ccccc1.CCOC(=O)C[C@H]1CC[C@@H](NC(=O)OC(C)(C)C)CN1>>CCOC(=O)C[C@H]1CC[C@@H](NC(=O)OC(C)(C)C)CN1Cc1ccccc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20050075331A1,CC(C)(C)OC(=O)Nc1ccc(N)c(S(N)(=O)=O)c1.CSC(SC)=C1C(=O)C=CN(CCC(C)C)C1=O>>CC(C)CCn1ccc(O)c(C2=NS(=O)(=O)c3cc(N)ccc3N2)c1=O,,C1COCCO1,,,,val
US04992432,CC(=O)Cl.COc1ccc(-c2ccccc2C(SCC(=O)c2ccccc2)C(O)C(N)=O)cc1>>COc1ccc(-c2ccccc2C(SCC(=O)c2ccccc2)C(OC(C)=O)C(N)=O)cc1,,ClCCl,,c1ccncc1,,val
US04985444,Cc1nnccc1-c1c(-c2ccccc2)nn2ccccc12.OC(O)C(Cl)(Cl)Cl>>OC(Cc1nnccc1-c1c(-c2ccccc2)nn2ccccc12)C(Cl)(Cl)Cl,,O,,ClCCl,c1ccncc1,val
US20110034445A1,Cn1ncnc1C(=O)c1ccccc1.NO>>Cn1ncnc1/C(=N\O)c1ccccc1,,c1ccncc1,,Cl,,val
US20110306592A1,O=C(Cl)C(=O)Cl.O=C(O)c1cc(C(F)(F)F)cnc1Cl>>O=C(Cl)c1cc(C(F)(F)F)cnc1Cl,,ClCCl,,CN(C)C=O,,val
US20120115942A1,Oc1ccc(C2=Cc3ccc(O)cc3OC2)cc1>>Oc1ccc(C2COc3cc(O)ccc3C2)cc1,[Pd],CO,,,,val
US20080015199A1,COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc2c(c(OC)c1)OCCC2.NNc1ncccn1>>COc1cc(C(Nc2ccc(-c3noc(C)n3)cc2)c2nn(-c3ncccn3)c(=O)[nH]2)cc2c1OCCC2,,CN(C)C=O,,CCN(CC)CC,,val
US20080009512A1,CC(C)(C)OC(=O)N[C@@H](CC(=O)O)Cc1ccccc1F.O=C1CCC(=O)N1O>>CC(C)(C)OC(=O)N[C@@H](CC(=O)ON1C(=O)CCC1=O)Cc1ccccc1F,,ClCCl,,CCN=C=NCCCN(C)C,,val
US20040072818A1,Clc1ccc2c(N3CCNCC3)ccnc2c1.NC1CCC1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>O=C(NC1CCC1)N1CCN(c2ccnc3cc(Cl)ccc23)CC1,,CO,ClCCl,CCN(C(C)C)C(C)C,,val
US20070264299A1,Cc1cc(I)cc2c(=O)oc(-c3cc(Cl)nn3-c3ncccc3Cl)nc12.N#C[Cu]>>Cc1cc(C#N)cc2c(=O)oc(-c3cc(Cl)nn3-c3ncccc3Cl)nc12,[Cu]I,C1CCOC1,CCOC(C)=O,,,val
US20050085468A1,COc1cc2c(=O)[nH]cnc2cc1[N+](=O)[O-]>>O=[N+]([O-])c1cc2ncnc(O)c2cc1O,,CC(=O)O,,Br,,val
US20140187533A1,CC(C)(C)OC(=O)N1CCN(C(=O)CC(=O)O)CC1.Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1N>>CC(C)(C)OC(=O)N1CCN(C(=O)CC(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2N)CC1,,ClCCl,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20080009486A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccc(Cl)cc1C=C1C(=O)Nc2cc(Cl)ccc21>>COC(=O)c1ccc(Cl)cc1C=C1C(=O)N(C(=O)OC(C)(C)C)c2cc(Cl)ccc21,CN(C)c1ccncc1,ClCCl,,,,val
US20070093643A1,CCCCCCC1(CCCCCC)c2ccccc2-c2ccc(Br)cc21.O=C1C(Br)=CC=C2C1=Cc1cc(Br)ccc12>>CCCCCCC1(CCCCCC)c2ccccc2-c2ccc(C3(O)c4cc(Br)ccc4-c4ccc(Br)cc43)cc21,,C1CCOC1,,O,,val
US20080261990A1,C#CCNCc1ccc(SC(C)(C)C(=O)OC(C)(C)C)cc1.Clc1cccc(-c2cc(Cl)ncn2)c1>>C#CCN(Cc1ccc(SC(C)(C)C(=O)OC(C)(C)C)cc1)c1cc(-c2cccc(Cl)c2)ncn1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20070172421A1,CN.Cc1cccc(C#CC=O)c1>>C/N=C/C#Cc1cccc(C)c1,,CCO,,,,val
US08022062B2,COc1c(C)ccc2c1CCN(C(=O)C(F)(F)F)CC2>>Cc1ccc2c(c1O)CCN(C(=O)C(F)(F)F)CC2,,ClCCl,,,,val
US20030125370A1,NC1CC1.O=C(O)[C@@H]1CCCN1C(=O)OCc1ccccc1>>O=C(NC1CC1)[C@@H]1CCCN1C(=O)OCc1ccccc1,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20120094997A1,CO.O=C(O)c1ccc2nc[nH]c(=O)c2c1>>COC(=O)c1ccc2nc[nH]c(=O)c2c1,,CO,,C1COCCO1,Cl,val
US20150126490A1,CC(C)(C)OC(=O)N1CCC(c2cnc(N)c(B3OC(C)(C)C(C)(C)O3)c2)CC1.O=C(N[C@H](CO)c1ccccc1)c1ccc(Br)cc1F>>Nc1ncc(C2CCNCC2)cc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)c(F)c1,,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20060040947A1,N#Cc1cccc(B(O)O)c1.O=c1cc(Cl)cn[nH]1>>N#Cc1cccc(-c2cn[nH]c(=O)c2)c1,,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20100222328A1,O=C(c1nc(C2CC2)sc1-c1ccc(F)cc1)N1CCC[C@H]1CNC(=O)C(F)(F)F>>NC[C@@H]1CCCN1C(=O)c1nc(C2CC2)sc1-c1ccc(F)cc1,,CC(C)O,CCOC(C)=O,[Na+].[OH-],,val
US20130296377A1,CCc1cc(C)c2[nH]cc(C(=O)C(F)(F)F)c2c1Cc1nc2cc(C#N)ccc2[nH]1>>CCc1cc(C)c2[nH]cc(C(O)C(F)(F)F)c2c1Cc1nc2cc(C#N)ccc2[nH]1,,CO,O,[BH4-].[Na+],,val
US20140330010A1,COC(=O)c1ccn(-c2ccc(OC3CCN(C4CCC4)CC3)cc2)c1>>O=C(O)c1ccn(-c2ccc(OC3CCN(C4CCC4)CC3)cc2)c1,,O,,CCO,[Na+].[OH-],val
US20120108582A1,C=CC[C@@]1(CO)CC(=O)N([C@H](C)c2ccccc2)C1.CI>>C=CC[C@@]1(COC)CC(=O)N([C@H](C)c2ccccc2)C1,,C1CCOC1,CO,CN(C)C=O,[H-].[Na+],val
US20160130254A1,CC1(C)C(=O)CCC1=O.OCCO>>CC1(C)C(=O)CCC12OCCO2,,Cc1ccccc1,,,,val
US04827004,CC(=O)CC/C=C(\C)CCC=C(C)C.CCN(CC)C(=O)CP(=O)(O)O>>CC(C)=CCC/C(C)=C/CC/C(C)=C/C(N)=O,,COCCOC,,O,[H-].[Na+],val
US20080188454A1,N#CNC(=Nc1ccc(OCCN2CCCC2)cc1)Oc1ccccc1.NNc1ncnc2c1CCCCCC2>>Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2c1CCCCCC2,,CC(C)O,,,,val
US20120010228A1,COC(=O)c1cccc(CN2CN(c3ccc(OC)cc3)C3(CCN(CCCn4c(=O)[nH]c5ccccc54)CC3)C2=O)c1>>COc1ccc(N2CN(Cc3cccc(C(=O)O)c3)C(=O)C23CCN(CCCn2c(=O)[nH]c4ccccc42)CC3)cc1,,CO,O,[Li+].[OH-],,val
US20090062293A1,CC(C)(C)CCC(=O)N1CCN(c2cc(-c3noc(C(Cl)(Cl)Cl)n3)ccn2)CC1.CNC>>CN(C)c1nc(-c2ccnc(N3CCN(C(=O)CCC(C)(C)C)CC3)c2)no1,,CO,,,,val
US20150152108A1,Clc1cccc(-c2ccc3c(n2)N[C@H]2CCN3C2)c1.O=C(Nc1ccccn1)Oc1ccccc1>>O=C(Nc1ccccn1)N1c2nc(-c3cccc(Cl)c3)ccc2N2CC[C@H]1C2,CN(C)c1ccncc1,CC#N,,,,val
US20090270363A1,N#Cc1ccc(N2CCCC2)cc1[N+](=O)[O-]>>N#Cc1ccc(N2CCCC2)cc1N,[Fe],CC(=O)O,CO,,,val
US20080076924A1,COc1c(OC)c(=O)c1=O.COc1ccc(CC(=O)N2CCNC(C(C)C)C2)cc1OC.Cc1ccccc1N>>COc1ccc(CC(=O)N2CCN(c3c(Nc4ccccc4C)c(=O)c3=O)C(C(C)C)C2)cc1OC,,CO,,CCN(CC)CC,,val
US04434175,COC(=O)c1cc(SC)c(C(=O)c2ccc(Cl)cc2)n1C>>CSc1cc(C(=O)O)n(C)c1C(=O)c1ccc(Cl)cc1,,CCO,,Cl,[Na+].[OH-],val
US20160075711A1,CC(=O)OC(C)=O.O=C(CC1c2ccccc2-c2cncn21)C1CCC(O)CC1>>CC(=O)OC1CCC(C(=O)CC2c3ccccc3-c3cncn32)CC1,CN(C)c1ccncc1,ClCCl,,,,val
US20130331377A1,CCCCC(=O)CC(=O)OCC.NC(N)=S>>CCCCc1cc(=O)[nH]c(=S)[nH]1,,O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120264790A1,COC(=O)C1(NC(=O)c2ccc(OC)c(O)c2)CCCCCC1.OCCc1cc(Cl)ccc1F>>COC(=O)C1(NC(=O)c2ccc(OC)c(OCCc3cc(Cl)ccc3F)c2)CCCCCC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080234261A1,COc1cccc(S(=O)(=O)NCCN2CCOCC2)c1>>O=S(=O)(NCCN1CCOCC1)c1cccc(O)c1,,ClCCl,,BrB(Br)Br,,val
US20050137224A1,CC(C)(C)OC(=O)N1[C@H](C(=O)N2CCC[C@H]2C#N)[C@@H]2C[C@@H](O)[C@H]1C2.Fc1ccccn1>>CC(C)(C)OC(=O)N1[C@H](C(=O)N2CCC[C@H]2C#N)[C@@H]2C[C@@H](Oc3ccccn3)[C@H]1C2,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US05840947,CC1Cc2c(cccc2-c2ccccn2)C1=O>>CC1=Cc2cccc(-c3ccccn3)c2C1,,C1CCOC1,CO,Cl,,val
US20090042929A1,CCN(CC)CC.NCc1cccs1.O=C(O)C12CC3CC(CC(O)(C3)C1)C2>>O=C(NCCc1cccs1)C12CC3CC(CC(O)(C3)C1)C2,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US20060074119A1,COC(=O)c1sc(-n2cnc3cc(O[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)c(OC)cc32)cc1OCc1ccccc1C(F)(F)F>>COC(=O)c1sc(-n2cnc3cc(O)c(OC)cc32)cc1OCc1ccccc1C(F)(F)F,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US06544989B2,COC(=O)Cc1ccc(O)c(N)c1.S=C(n1ccnc1)n1ccnc1>>COC(=O)Cc1ccc2oc(=S)[nH]c2c1,,Cc1ccccc1,,CC(=O)O,,val
US20090181953A1,COc1ccc(C(=O)CC#N)cc1.NN>>COc1ccc(-c2cc(N)n[nH]2)cc1,,CCO,,O,,val
US20140288260A1,Brc1ccc2c(c1)Sc1ccccc1S2.CCO[Ge](OCC)(OCC)OCC>>CCO[Ge](OCC)(OCC)c1ccc2c(c1)Sc1ccccc1S2,,C1CCOC1,,[Mg],,val
US20130029948A1,CCOC(=O)CBr.Ic1cn[nH]c1>>CCOC(=O)Cn1cc(I)cn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06858739B2,COc1ccc(-c2nc3cc(Cl)c(Cl)cc3[nH]2)cc1[N+](=O)[O-]>>COc1ccc(-c2nc3cc(Cl)c(Cl)cc3[nH]2)cc1N,[Zn],CC(=O)O,,,,val
US20150291595A1,CNS(=O)(=O)c1ccc(OC(=O)c2c(Cl)ncnc2Cl)cc1.N>>CNS(=O)(=O)c1ccc(OC(=O)c2c(N)ncnc2Cl)cc1,,C1COCCO1,,,,val
US20150329542A1,CNC.COc1ccc(N(C)S(C)(=O)=O)c(CNc2nc(-c3cc(F)c(OC)cc3CC(F)(F)F)nc3[nH]nc(-c4nc5c([nH]4)CCNC5)c23)c1.O=C=NCCBr>>CN(C)CCNC(=O)N1CCc2[nH]c(-c3n[nH]c4nc(-c5cc(F)c(O)cc5CC(F)(F)F)nc(NCc5cc(O)ccc5N(C)S(C)(=O)=O)c34)nc2C1,,C1CCOC1,ClCCl,BrB(Br)Br,,val
US20040038987A1,COC(=O)c1cccc(O)c1C(=O)OC.O=[N+]([O-])O>>COC(=O)c1ccc([N+](=O)[O-])c(O)c1C(=O)OC,,CC#N,O,CC(=O)OC(C)=O,,val
US20040077669A1,CC#CCO.Cc1ccccc1Cc1cc(Cl)ncn1>>CC#CCOc1cc(Cc2ccccc2C)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20110172209A1,Nc1ccccc1Cl.O=[N+]([O-])c1ccc(Cl)nc1Cl>>O=[N+]([O-])c1ccc(Cl)nc1Nc1ccccc1Cl,,CCO,,,,val
US04550105,COC(=O)[C@H]1NC(=O)[C@H]1N.CON=C(C(=O)Cl)c1csc(NC(=O)CCl)n1>>CON=C(C(=O)N[C@@H]1C(=O)N[C@@H]1C(=O)OC)c1csc(NC(=O)CCl)n1,,C1CCOC1,,O,O=C([O-])O.[Na+],val
US20120309739A1,COc1nc(NCCN)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c12>>COc1nc(NCCN)nc2oc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160176843A1,COC(=O)c1ccccc1CN(CCc1ccc(Cl)cc1)C1CCN(C(=O)OC(C)(C)C)CC1.Cl>>COC(=O)c1ccccc1CN(CCc1ccc(Cl)cc1)C1CCNCC1.Cl,,CCOC(C)=O,,,,val
US20120053204A1,COCc1nc2cc(C(F)(F)F)ccc2c(C)c1C(=O)OC>>COCc1nc2cc(C(F)(F)F)ccc2c(C)c1C(=O)O,,C1CCOC1,,[Li+].[OH-],,val
US20030232818A1,CCOC(=O)c1cn(CCC#N)c2nc(N3CC(NC(=O)OC(C)(C)C)C3)c(F)cc2c1=O>>CC(C)(C)OC(=O)NC1CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3CCC#N)C1,,C1CCOC1,CO,[Li+].[OH-],,val
US20150366197A1,CC(C)(C)[Si](C)(C)Cl.Cc1ccc(S(=O)(=O)n2ccc(-n3cccc3CO)c2C=O)cc1>>Cc1ccc(S(=O)(=O)n2ccc(-n3cccc3CO[Si](C)(C)C(C)(C)C)c2C=O)cc1,,ClCCl,,c1c[nH]cn1,,val
US20060276508A1,CC(C)(C)OC(=O)N1CCC(NC(=O)c2cccc(OS(C)(=O)=O)c2)CC1>>CS(=O)(=O)Oc1cccc(C(=O)NC2CCNCC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110201593A1,O=C(OCC1c2ccccc2-c2ccccc21)N1CCCC(Nc2c([N+](=O)[O-])cnc3c2ccn3S(=O)(=O)c2ccccc2)C1>>Nc1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1NC1CCCN(C(=O)OCC2c3ccccc3-c3ccccc32)C1,[Pd],CCO,,C1CCOC1,,val
US20130190289A1,COC(=O)c1sc(C#CC(C)(C)C)cc1NC(C)CC(=O)N1CCCC1.C[C@@H]1CC[C@@H](C(=O)Cl)CC1>>COC(=O)c1sc(C#CC(C)(C)C)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C(C)CC(=O)N1CCCC1,,ClCCCl,ClCCl,c1ccncc1,,val
US20130231358A1,COC(=O)c1ccc(CBr)c(CBr)c1.O=C1Cc2c(Cl)ncnc2N1>>COC(=O)c1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncnc(Cl)c21,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05494928,CC(=O)Oc1cn(C(C)=O)c2ccc(F)cc12>>CC(=O)N1CC(=O)c2cc(F)ccc21,,O=S(=O)(O)O,,,,val
US06043368,C1COCOC1.Cl.Clc1ccccc1CNCCc1cccs1>>Cl.Clc1ccccc1CN1CCc2sccc2C1,,CC(C)O,,Cl,,val
US04236005,CCOC(=O)c1nc[nH]c1N.CN(C)C=CC(=O)c1ccccc1>>CCOC(=O)c1ncn2c(-c3ccccc3)ccnc12,,CC(=O)O,,,,val
US04705801,COC=Cc1cccc(Cl)c1Cl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COC=C(C(=O)C(F)(F)F)c1cccc(Cl)c1Cl,,ClCCl,,c1ccncc1,,val
US20090286791A1,CCOC(=O)c1cn(-c2ccccc2)nc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)Nc1nn(-c2ccccc2)cc1C(=O)O,,CCO,,[Na+].[OH-],,val
US20150238558A1,COC(=O)c1ccc(CN(C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)[C@H](C)c2ccc(F)cc2)cc1>>COC(=O)c1ccc(CN(C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](N)C(C)(C)C)[C@H](C)c2ccc(F)cc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030065005A1,O=[N+]([O-])c1c(Oc2ccccc2)nc2c(c1NCCOCCCc1cccnc1)CCCC2>>Nc1c(Oc2ccccc2)nc2c(c1NCCOCCCc1cccnc1)CCCC2,[Pt],Cc1ccccc1,,[H][H],,val
US20120101099A1,Cc1cccc(C(=O)O)c1.NC(=O)CCC(=O)NBr>>O=C(O)c1cccc(CBr)c1,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,,,val
US20100216798A1,COCCBr.O=C1c2ccccc2C(=O)N1[C@@H]1CC[C@@H](O)CC1>>COCCO[C@@H]1CC[C@@H](N2C(=O)c3ccccc3C2=O)CC1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20140066424A1,Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1cccc(OCCNC(=O)OC(C)(C)C)c1>>Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1cccc(OCCN)c1,,CO,,CC(=O)Cl,,val
US20160185773A1,CC(C)(C)OC(=O)NCc1ccc(CNc2nccc3[nH]ccc23)cc1.O=c1ccccn1Cc1ccc(CBr)cc1>>CC(C)(C)OC(=O)NCc1ccc(CNc2nccc3c2ccn3Cc2ccc(Cn3ccccc3=O)cc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20060052599A1,CC(C)(C)OC(=O)N1CC[C@@H](Nc2ncc(C=O)cc2Cl)C1.CCOC(C)=O>>CCOC(=O)/C=C/c1cnc(N[C@@H]2CCN(C(=O)OC(C)(C)C)C2)c(Cl)c1,,C1CCOC1,,O,[H-].[Na+],val
US20150018363A1,Cl.Cn1c(C2CC2)nc2ccc(-n3ccc(OCc4ccc(C(F)(F)F)s4)cc3=O)cc21>>Cl.Cn1c(C2CC2)nc2ccc(-n3ccc(OCc4ccc(C(F)(F)F)s4)cc3=O)cc21,,CCOC(C)=O,,,,val
US20100160335A1,COc1cccc2c1NC(C(F)(F)F)CC2>>COc1cccc2ccc(C(F)(F)F)nc12,,CC(=O)O,,[Na+].[OH-],,val
US20130331374A1,CC1(C)C[C@H](Nc2nc(Cl)ncc2F)C[C@@H]2CCCN21.Cn1nnn(-c2cc(N)ccc2N2CCN(C3COC3)CC2)c1=O>>Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2N2CCN(C3COC3)CC2)c1=O,,CC(C)O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20130045986A1,CCC(C)O.CN(C)C=O.Fc1cc(-n2cnnn2)ccc1-c1ccc2oc(C3CCNCC3)nc2c1>>CCC(C)OC(=O)N1CCC(c2nc3cc(-c4ccc(-n5cnnn5)cc4F)ccc3o2)CC1,,CN(C)C=O,,O=C(O)C(F)(F)F,,val
US20040084383A1,O=S(=O)([O-])OOS(=O)(=O)[O-].[Br-].[Na+].[Na+].[Na+]>>O=S(=O)([O-])OOS(=O)(=O)[O-].[Br-].[Na+].[Na+].[Na+],,O,,,,val
US04456464,COP(=O)(COc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-])OC.O=S(Cl)Cl>>COP(=O)(Cl)COc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],,c1ccccc1,,,,val
US04428965,COc1cccc(CBr)c1OC.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1OC.[Br-],,Cc1ccccc1C,,,,val
US20160115128A1,Cc1ccnc(N)c1.O=CC1CC1>>Cc1ccnc(NCC2CC2)c1,,CC(=O)O,,[Na+].[OH-],,val
US20110136780A1,CC(C)[C@@H](N)C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)n2cc(C(=O)[O-])c3c(C=O)c(F)cnc32)cc1>>Cc1ccc(S(=O)(=O)n2cc(C(=O)O)c3c(CN[C@@H](C(=O)OC(C)(C)C)C(C)C)c(F)cnc32)cc1,,ClCCl,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20080312234A1,O=C(O)C=Cc1ccc(C(F)(F)F)nc1Cl.Oc1ccccc1>>O=C(O)C=Cc1ccc(C(F)(F)F)nc1Oc1ccccc1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US05283361,Fc1ccc(Sc2ccccc2C=CCNOC2CCCCO2)cc1>>ONCC=Cc1ccccc1Sc1ccc(F)cc1,,CO,,Cl,,val
US20140008617A1,Brc1cccc(-c2ccccn2)c1.Cl[Si](c1ccccc1)(c1ccccc1)c1ccccc1>>c1ccc([Si](c2ccccc2)(c2ccccc2)c2cccc(-c3ccccn3)c2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20100069367A1,CCOC(=O)c1cc(CBr)n(-c2c(Cl)cccc2Cl)n1.Oc1ccc(Br)cc1>>CCOC(=O)c1cc(COc2ccc(Br)cc2)n(-c2c(Cl)cccc2Cl)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US07795247B2,COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCN(CC(=O)OC(C)(C)C)Cc1ccccc1-3>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCN(CC(=O)O)Cc1ccccc1-3,,ClCCl,O,O=C(O)C(F)(F)F,,val
US06538015B1,CC(C)n1nc(CCl)c(Cc2ccncc2)c1Sc1cc(Cl)cc(Cl)c1.[N-]=[N+]=[N-]>>CC(C)n1nc(CN=[N+]=[N-])c(Cc2ccncc2)c1Sc1cc(Cl)cc(Cl)c1,,CN(C)C=O,,Cl,,val
US20040254215A1,CB1OB(C)OB(C)O1.COC(=O)c1nc(Br)c2cc(Sc3ccccc3)ccc2c1O>>COC(=O)c1nc(C)c2cc(Sc3ccccc3)ccc2c1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20130210796A1,C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1Cc1nnnn1-c1cccc(C(F)(F)F)c1>>C[C@@H]1CNCCN1Cc1nnnn1-c1cccc(C(F)(F)F)c1,,CO,,C1COCCO1,Cl,val
US20130109678A1,CCCC[Sn](CCCC)(CCCC)c1cc2ccc(N3CCN(C)CC3)cc2n1S(=O)(=O)c1ccc(C)cc1.Nc1ccc(Br)cc1[N+](=O)[O-]>>Cc1ccc(S(=O)(=O)n2c(-c3ccc(N)c([N+](=O)[O-])c3)cc3ccc(N4CCN(C)CC4)cc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20060173018A1,Cc1ccc2c(N3CCN(C(=O)C=CC(C)(C)F)CC3)nc(-c3ccccc3O)nc2c1>>Cc1ccc2c(N3CCN(C(=O)CCC(C)(C)F)CC3)nc(-c3ccccc3O)nc2c1,[Pd],CO,,[H][H],,val
US20110021522A1,Nc1cccc(-c2cnn(Cc3ccccc3)c2)c1.O=C(O)c1cc2cccc(O)c2oc1=O>>O=C(Nc1cccc(-c2cnn(Cc3ccccc3)c2)c1)c1cc2cccc(O)c2oc1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060142322A1,NC(=O)C1Cc2c([nH]c3ccccc23)CN1.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1>>NC(=O)C1Cc2c([nH]c3ccccc23)CN1S(=O)(=O)c1cccc([N+](=O)[O-])c1,,CC(C)=O,CN(C)C=O,CCN(CC)CC,O,val
US04437878,CCO.COC(=O)C1CSCC1=O>>CCOC(=O)C1CSCC1=O,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20130225591A1,O=C(Cc1ccc2ccccc2c1)Nc1ncn2c(C(F)(F)F)c(C(=O)[O-])sc12>>O=C(Cc1ccc2ccccc2c1)Nc1ncn2c(C(F)(F)F)c(C(=O)O)sc12,,C1CCOC1,,CC(=O)O,[Li+].[OH-],val
US20060258571A1,CC(C)(C)OC(=O)N[C@@H](Cc1cc(-c2ccc(OCc3ccccc3)c(C[C@H](NC(=O)OCc3ccccc3)C(=O)OCC[Si](C)(C)C)c2)ccc1OCc1ccccc1)C(=O)OCc1ccccc1.Cl>>C[Si](C)(C)CCOC(=O)[C@H](Cc1cc(-c2ccc(OCc3ccccc3)c(C[C@H](N)C(=O)OCc3ccccc3)c2)ccc1OCc1ccccc1)NC(=O)OCc1ccccc1.Cl,,C1COCCO1,,,,val
US20140051676A1,CCOC(=O)c1ccc(OC2CCOCC2)nc1>>O=C(O)c1ccc(OC2CCOCC2)nc1,,CCO,,[Na+].[OH-],,val
US20110294781A1,C1COCCN1.Clc1cc(Cl)n2ncc(-c3ccccc3)c2n1>>Clc1cc(N2CCOCC2)n2ncc(-c3ccccc3)c2n1,,C1COCCO1,,,,val
US20130345190A1,CC(C)(C)OC(=O)N=C(NCc1cc([C@@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)no1)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N=C(NCc1cc([C@@H]2CC[C@@H]3CN2C(=O)N3O)no1)NC(=O)OC(C)(C)C,[Pd],C1CCOC1,,,,val
US04481268,NN.NS(=O)(=O)c1cc([N+](=O)[O-])ccc1Cl>>NNc1ccc([N+](=O)[O-])cc1S(N)(=O)=O,,CCO,,O,,val
US04293696,O=C(O)CC(Sc1nc2ncccc2[nH]1)C(=O)c1ccc(Cl)cc1>>O=C(O)CC(Sc1nc2ncccc2[nH]1)C(=O)c1ccc(Cl)cc1,,O=C([O-])O,[Na+],Br,,val
US20090124596A1,CCC=O.NC1(C(=O)N[C@@H]2CC[C@H](n3c(=O)c4cc(F)cnc4n(-c4cccc(-c5ccccc5CN5CCOCC5)c4)c3=O)CC2)CCCC1>>CCCNC1(C(=O)N[C@@H]2CC[C@H](n3c(=O)c4cc(F)cnc4n(-c4cccc(-c5ccccc5CN5CCOCC5)c4)c3=O)CC2)CCCC1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070117866A1,CC(C)(C)N.CC(C)O[C@@H](Cc1cccc(O)c1)C(=O)O>>CC(C)(C)N.CC(C)O[C@@H](Cc1cccc(O)c1)C(=O)O,,COCCOC,,,,val
US20120165333A1,COc1ccc(-n2nnnc2-c2cccnc2NC(C)(C)C)c(F)c1F>>COc1ccc(-n2nnnc2-c2cccnc2N)c(F)c1F,,CO,Cl,[Na+].[OH-],,val
US20160176850A1,COC[C@@H](C)O.CS(=O)(=O)c1nc(Cl)cc(Cl)n1>>COC[C@@H](C)Oc1nc(Cl)cc(Cl)n1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20090042929A1,Nc1ccccc1.O=C(O)Cc1ccc(OCC(=O)C23CC4CC(CC(C4)C2)C3)cc1>>O=C(Cc1ccc(OCC(=O)C23CC4CC(CC(C4)C2)C3)cc1)Nc1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US20110201591A1,CCCC[Sn](CCCC)(CCCC)c1nccs1.COC(=O)c1cc(Cl)ncc1Br>>COC(=O)c1cc(Cl)ncc1-c1nccs1,,CCOC(C)=O,,C1COCCO1,,val
US20150291593A1,CCOC(=O)c1[nH]ccc1Br.NOc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>CCOC(=O)c1c(Br)ccn1N,,CN(C)C=O,,O,[H-].[Na+],val
US20110144105A1,CS(=O)(=O)c1ccc(B(O)O)cc1.Cc1ccc(S(=O)(=O)OC(=CC2CCOCC2)c2cc3cc(F)cnc3n2S(=O)(=O)c2ccccc2)cc1>>CS(=O)(=O)c1ccc(C(=CC2CCOCC2)c2cc3cc(F)cnc3n2S(=O)(=O)c2ccccc2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20110301109A1,CCCOc1ccc(NC(=S)NCC)cc1-c1nc(C(C)C)c(Br)c(=O)[nH]1.CI>>CCCOc1ccc(NC(=NCC)SC)cc1-c1nc(C(C)C)c(Br)c(=O)[nH]1,,CO,,,,val
US20090143372A1,CC(C)CCNCc1ccc(B(O)O)s1.CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(Br)cc23)CC1>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccc(CNCCC(C)C)s4)cc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20110046133A1,COC(=O)c1ccc2cc(-c3c(Cl)cccc3Cl)[nH]c2c1>>O=C(O)c1ccc2cc(-c3c(Cl)cccc3Cl)[nH]c2c1,,CCO,CCOC(C)=O,Cl,[Na+].[OH-],val
US20140329797A1,CC(C)(c1ccc(-c2noc(-c3ccc(=O)n(Cc4cccc(C(=O)Cl)c4)n3)n2)cc1)C(F)(F)F.CC(C)N>>CC(C)NC(=O)c1cccc(Cn2nc(-c3nc(-c4ccc(C(C)(C)C(F)(F)F)cc4)no3)ccc2=O)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20030105070A1,CC(=O)OC(C)=O.OCc1ccc(N(c2ccccc2)c2ccccc2)cc1>>CC(=O)OCc1ccc(N(c2ccccc2)c2ccccc2)cc1,,O,,c1ccncc1,,val
US20160206616A1,CCOC(=O)C1=C(CBr)NC(c2nccs2)=N[C@H]1c1ccc(Cl)cc1Cl.O=C(O)CC[C@H]1CCC(F)(F)CN1>>CCOC(=O)C1=C(CN2CC(F)(F)CC[C@@H]2CCC(=O)O)NC(c2nccs2)=N[C@H]1c1ccc(Cl)cc1Cl,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US04124719,CCOC(=O)N1CCC2C1CCCC2(O)c1ccc(Cl)cc1>>CN1CCC2C1CCCC2(O)c1ccc(Cl)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05817691,Clc1ccc(-c2[nH]ccc2Sc2ccccc2)cc1.O=S(=O)([O-])O[O-]>>O=S(=O)(c1ccccc1)c1cc[nH]c1-c1ccc(Cl)cc1,,CO,,O,,val
US20140038952A1,CC(C)(C)OC(=O)Nc1ncc(-c2nc(N3CCOCC3)c3ncc(-c4cccc(N)c4)cc3n2)cn1.O=S(=O)(Cl)c1ccc(F)cc1>>CC(C)(C)OC(=O)Nc1ncc(-c2nc(N3CCOCC3)c3ncc(-c4cccc(NS(=O)(=O)c5ccc(F)cc5)c4)cc3n2)cn1,,CO,ClC(Cl)Cl,c1ccncc1,,val
US20060128685A1,CCOC(=O)c1cc(-c2ccc(Cl)cn2)n(-c2ccc(Cl)nn2)n1.CO>>COc1ccc(-n2nc(C(=O)O)cc2-c2ccc(Cl)cn2)nn1,,CO,,C[O-].[Na+],,val
US06660744B1,COc1cc(-c2nn([C@@H]3CC[C@@H](N4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1N.O=C(Cl)c1ccc(OC(F)(F)F)cc1>>COc1cc(-c2nn([C@@H]3CC[C@@H](N4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)c1ccc(OC(F)(F)F)cc1,,ClCCl,c1ccncc1,,,val
US20150266881A1,Cc1cc(NC(=O)c2cccc(C3CC3N)c2)n(C)n1.Cl.Cl.O=C1CCC1>>Cc1cc(NC(=O)c2cccc([C@@H]3C[C@H]3NC3CCC3)c2)n(C)n1.Cl.Cl,,CC(=O)O,CO,O=C([O-])O.[Na+],,val
US20140350019A1,COc1c(C)cc(-c2cccc(F)c2)cc1C(=O)Nc1c(F)ccc(O)c1F>>COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(O)c1F,,C1CCOC1,,,,val
US20070161617A1,CCS(=O)(=O)Cl.Cc1cc(NC(=O)Nc2cccc(CN3CCN(C(=O)OC(C)(C)C)CC3)c2F)ccn1>>CCS(=O)(=O)N1CCN(Cc2cccc(NC(=O)Nc3ccnc(C)c3)c2F)CC1,,CO,ClCCl,CCN(CC)CC,Cl,val
US20060142265A1,CN.Cn1ccc2c(C=O)cccc21>>CNCc1cccc2c1ccn2C,,CO,,O,[BH4-].[Na+],val
US20150342185A1,CCCC[Sn](C#C[Si](C)(C)C)(CCCC)CCCC.COc1cc(Br)cc(Cl)c1C1C(=O)CC2(CCOCC2)CC1=O>>COc1cc(C#C[Si](C)(C)C)cc(Cl)c1C1C(=O)CC2(CCOCC2)CC1=O,,CCOC(C)=O,Cc1ccccc1,,,val
US20150266837A1,CN(C)c1ccc(C=O)cc1.CN(N)c1nnn[nH]1>>CN(C)c1ccc(/C=N/N(C)c2nnn[nH]2)cc1,,C1COCCO1,,Cl,,val
US20030105151A1,Cc1c(CCC(=O)O)c[nH]c1C=O.O=C(O)CCc1ccc2c(c1)CC(=O)N2>>Cc1c(CCC(=O)O)c[nH]c1C=C1C(=O)Nc2ccc(CCC(=O)O)cc21,,CCO,,C1CCNCC1,,val
US20060264415A1,Fc1ccc(S)cc1.O=C(O)CCCCCNC(=O)CCl>>O=C(O)CCCCCNC(=O)CSc1ccc(F)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20100035883A1,C1CNC1.O=Cc1ccc(C2Nc3cccc4c(=O)[nH]nc(c34)C2c2ccc(F)cc2)cc1>>O=c1[nH]nc2c3c(cccc13)NC(c1ccc(CN3CCC3)cc1)C2c1ccc(F)cc1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120252810A1,CC(C)(C)OC(=O)NCCSSCCN.O=C(O)C/C=C/c1cccnc1>>CC(C)(C)OC(=O)NCCSSCCNC(=O)C/C=C/c1cccnc1,,CC#N,CCOC(C)=O,CCN=C=NCCCN(C)C,,val
US05034417,CC(=O)c1ccc(N)c(Nc2ccc(F)cc2F)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(=O)c1ccc(NS(=O)(=O)C(F)(F)F)c(Nc2ccc(F)cc2F)c1,,ClCCl,,CCN(CC)CC,,val
US06923950B2,CCc1c(I)cc(I)c(-c2ccc(C(=O)O)c([N+](=O)[O-])c2)c1I.O=S(Cl)Cl>>CCc1c(I)cc(I)c(-c2ccc(C(=O)Cl)c([N+](=O)[O-])c2)c1I,[Zn],,,,,val
US05166367,CCI.O=c1ccc2ccc(OCCCNC[C@H]3COc4ccc(O)cc4O3)cc2o1>>CCN(CCCOc1ccc2ccc(=O)oc2c1)C[C@H]1COc2ccc(O)cc2O1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20020133007A1,Fc1ccc(F)c(Cl)c1.O=[N+]([O-])O>>O=[N+]([O-])c1cc(F)c(Cl)cc1F,,O=S(=O)(O)O,,,,val
US20100249095A1,CC(C)(C)OC(=O)N1CCCC2(CC1)CCN(c1ccncc1)CC2>>c1cc(N2CCC3(CCCNCC3)CC2)ccn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090074717A1,C#Cc1ccncc1.OCc1ccc(I)cc1>>OCc1ccc(C#Cc2ccncc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCN(CC)CC,,Cl,,val
US05929074,CCBr.COc1ccc(CNc2cn[nH]c(=O)c2Cl)cc1OCCN1CCN(Cc2ccc(F)cc2)CC1>>CCn1ncc(NCc2ccc(OC)c(OCCN3CCN(Cc4ccc(F)cc4)CC3)c2)c(Cl)c1=O,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05639881,COc1c(NC(=O)COc2ccccc2)c(C(N)=O)c(OC)c(NC(=O)COc2ccccc2)c1C(N)=O>>COc1c2nc(COc3ccccc3)[nH]c(=O)c2c(OC)c2nc(COc3ccccc3)[nH]c(=O)c12,,CC(=O)O,,O=S(=O)(O)O,,val
US20040009995A1,COC(=O)c1cc(Br)c([N+](=O)[O-])s1.Sc1ccc2ccccc2c1>>COC(=O)c1cc(Sc2ccc3ccccc3c2)c([N+](=O)[O-])s1,,CN(C)C=O,,[H-].[Na+],,val
US05864039,COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCCN)CC1.O=C(Cl)c1ccccc1>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCCNC(=O)c2ccccc2)CC1,,ClCCl,ClCCl,CCN(CC)CC,,val
US05658943,COC(=O)CNC(=O)OC(C)(C)C.COP(OC)OC>>COC(=O)C(NC(=O)OC(C)(C)C)P(=O)(OC)OC,,ClC(Cl)(Cl)Cl,,O=C1CCC(=O)N1Br,,val
US04352818,CCOC(=O)c1ncn2c1CN(C)C(=O)c1ccccc1-2.NN>>CN1Cc2c(C(=O)NN)ncn2-c2ccccc2C1=O,,CCO,,O,,val
US20040058964A1,C[Si](C)(C)C=[N+]=[N-].O=C(O)Cc1ccccc1CBr>>COC(=O)Cc1ccccc1CBr,,C1CCOC1,,,,val
US20100179168A1,Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(NC(=O)C(C)(C)NC(=O)OC(C)(C)C)ccc3Cl)cc2F)o1.Cl>>Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(NC(=O)C(C)(C)N)ccc3Cl)cc2F)o1.Cl,,C1COCCO1,,,,val
US20100292208A1,COC(=O)c1cc2ccc(Oc3nc4ccccc4s3)cc2s1>>OCc1cc2ccc(Oc3nc4ccccc4s3)cc2s1,,ClCCl,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20140200205A1,CC(=O)SCCCCC[C@H](NC(=O)[C@@H]1CCCC(=O)N1)C(=O)Nc1ccccc1>>O=C1CCC[C@@H](C(=O)N[C@@H](CCCCCS)C(=O)Nc2ccccc2)N1,,CCO,,O,[Na+].[OH-],val
US20070149446A1,CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C.COC(=O)C[C@H](O)[C@H](NC(=O)OCc1ccccc1)C(C)C>>COC(=O)C[C@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@H](NC(=O)OCc1ccccc1)C(C)C,,ClCCl,,Cc1cccc(C)n1,,val
US20080045526A1,CCNCC.O=Cc1ccc2c(n1)COC2=O>>CCN(CC)Cc1ccc2c(n1)COC2=O,,CC(Cl)Cl,,O=C([O-])O.[Na+],,val
US03959322,CCC1(CCC(=O)CCC(C)c2cccc(OC)c2)C(=O)CCC1=O.OCCO>>CC[C@]12CCC3=C(CC(C)c4cc(OC)ccc43)C1=CCC21OCCO1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20020091148A1,COC(=O)c1[nH]c2ccccc2c1S(=O)(=O)c1ccccc1.NN>>NNC(=O)c1[nH]c2ccccc2c1S(=O)(=O)c1ccccc1,,CCO,,O,,val
US20160168156A1,CC(C)(C)OC(=O)N1CCN(C(=O)Cn2cc(-c3cnn4ccc(N5CCC[C@@H]5c5cc(F)ccc5F)nc34)nn2)CC1>>O=C(Cn1cc(-c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)nn1)N1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030060467A1,Cc1ccc(S(=O)(=O)Oc2cc3c(C)nnc(-c4ccccc4F)n3n2)cc1>>Cc1nnc(-c2ccccc2F)n2nc(O)cc12,,C1COCCO1,O,[Na+].[OH-],,val
US04794109,CC(C)=C(Cl)N(C)C.O=C(O)Cn1cnnn1>>O=C(Cl)Cn1cnnn1,,ClCCl,,,,val
US20110034450A1,COC(=O)c1ccc(CNC(=O)C(c2ccc(CN3N=C(c4ccccc4)OCC3=O)cc2)C2CCCC2)cc1>>O=C(O)c1ccc(CNC(=O)C(c2ccc(CN3N=C(c4ccccc4)OCC3=O)cc2)C2CCCC2)cc1,,C1COCCO1,O,[Na+].[OH-],[Cl-].[NH4+],val
US20070135452A1,CCCNCCC.Cc1cc(C)c(Nc2nc3cc([N+](=O)[O-])cc(C(=O)O)c3s2)c(C)c1>>CCCN(CCC)C(=O)c1cc([N+](=O)[O-])cc2nc(Nc3c(C)cc(C)cc3C)sc12,,CN(C)C=O,O,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US06350749B1,Cc1ccnc2c1C(=O)CC(c1ccco1)C2.Cl.N=C(N)NN>>Cc1ccnc2c1C(=NNC(=N)N)CC(c1ccco1)C2.Cl,,CCO,,Cl,,val
US20100056530A1,Nc1ncc(Br)nc1OCc1ccccc1.O=C(N=C=S)c1ccccc1>>O=C(NC(=S)Nc1ncc(Br)nc1OCc1ccccc1)c1ccccc1,,C1CCOC1,,,,val
US05216026,CCC(C)S(N)(=O)=O.O=C=Nc1ccc(Cl)cc1>>CCC(C)S(=O)(=O)NC(=O)Nc1ccc(Cl)cc1,,C1CCOC1,,CO,C[O-].[Na+],val
US05342833,CC(C)C(C)(C)[Si](C)(C)Cl.C[C@]12CC[C@H]3C(=CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O>>CC(C)C(C)(C)[Si](C)(C)O[C@H]1CC[C@@]2(C)C(=CC=C3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]32)C1,,ClCCl,,c1c[nH]cn1,,val
US04584187,N=C(N)NCc1cccc(I)c1.O=S(=O)(O)O>>N=C(N)NCc1cccc(I)c1.O=S(=O)(O)O,,O,,O=C(O)O,,val
US20050261177A1,CC(Br)CCCOCC1CCN(C(=O)OC(C)(C)C)CC1.CO>>COCCCCCOCC1CCN(C(=O)OC(C)(C)C)CC1,,[Na+],[OH-],,,val
US20020019390A1,Cn1cc([N+](=O)[O-])cc([N+](=O)[O-])c1=O.O=C1CCN(Cc2ccccc2)CC1>>O=[N+]([O-])c1cnc2c(c1)CN(Cc1ccccc1)CC2,,CO,,N,,val
US20140288123A1,CC(c1ccccc1)c1ccc(C(=O)O)cc1.Cc1cc(C)c(CN)c(O)n1>>Cc1cc(C)c(CNC(=O)c2ccc(C(C)c3ccccc3)cc2)c(O)n1,,ClCCl,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130331378A1,COC(=O)c1cccc(C=O)n1.COc1cccc2c(Br)c(-c3ccccc3)nn12>>COC(=O)c1cccc(C(O)c2c(-c3ccccc3)nn3c(OC)cccc23)n1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US04338121,CC(N)C(=O)O.Cc1cc([N+](=O)[O-])c(Cl)c([N+](=O)[O-])c1>>Cc1cc([N+](=O)[O-])c(NC(C)C(=O)O)c([N+](=O)[O-])c1,,CCO,O,O=C([O-])O.[Na+],,val
US20100160303A1,C=CS(=O)(=O)C=C.NC(=O)c1ccc(-c2ccccc2F)c2c1[nH]c1cc(N)ccc12>>NC(=O)c1ccc(-c2ccccc2F)c2c1[nH]c1cc(N3CCS(=O)(=O)CC3)ccc12,,CC(C)O,,,,val
US20150157629A1,CC(C)(C)OC(=O)Nc1cnc(CBr)cn1.CCN1CCN(Cc2ccc(C(=O)Nc3ccc(C)c(N)c3)cc2C(F)(F)F)CC1>>CCN1CCN(Cc2ccc(C(=O)Nc3ccc(C)c(NCc4cnc(N)cn4)c3)cc2C(F)(F)F)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070066617A1,CCOC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1[N+](=O)[O-]>>CCOC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1N,,CCOC(C)=O,,CC(=O)O,O,val
US20050131017A1,CC[C@H](C)[C@@H](C(=O)OC(C)(C)C)N1CCN(Cc2cccnc2C)C1=O>>CC[C@H](C)[C@@H](C(=O)O)N1CCN(Cc2cccnc2C)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04740515,CC(=O)C(C)(C)C.CCOP(=O)(Cc1ccc(Cl)cc1Cl)OCC>>CC(=Cc1ccc(Cl)cc1Cl)C(C)(C)C,,Cc1ccccc1,,,,val
US20110009454A1,N.O=C(NCc1ccc(Oc2ccccc2)cc1)c1ccc(F)nc1F>>Nc1nc(F)ccc1C(=O)NCc1ccc(Oc2ccccc2)cc1,,C1COCCO1,,,,val
US04933333,COc1ccc(CC(Cc2ccc(OC)cc2)N2C(=O)C(C(C)OC(=O)OCc3ccc([N+](=O)[O-])cc3)C2CC(=O)C(C(=O)OCc2ccc([N+](=O)[O-])cc2)C(=O)OC(C)(C)C)cc1>>COc1ccc(CC(Cc2ccc(OC)cc2)N2C(=O)C(C(C)OC(=O)OCc3ccc([N+](=O)[O-])cc3)C2CC(=O)CC(=O)OCc2ccc([N+](=O)[O-])cc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110144136A1,CCCCOc1nc(N)c2nc(OC)n(CCCC3CCCCN3)c2n1>>CCCCOc1nc(N)c2[nH]c(=O)n(CCCC3CCCCN3)c2n1,,CO,CS(C)=O,C1COCCO1,Cl,val
US20150361100A1,CC(c1cc2ccccn2c1CN1CC2(CCN(C(=O)OC(C)(C)C)CC2)C1)n1nc(I)c2c(N)ncnc21.OB(O)c1cc(O)cc(F)c1>>CC(c1cc2ccccn2c1CN1CC2(CCN(C(=O)OC(C)(C)C)CC2)C1)n1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20090048320A1,CC(C)N.CN1C(=O)C(c2ccc(OC(F)F)cc2)(c2cccc(C=O)c2)N=C1N>>CC(C)NCc1cccc(C2(c3ccc(OC(F)F)cc3)N=C(N)N(C)C2=O)c1,,CO,,[Na+].[OH-],,val
US05508435,COC(=O)C1CCCC1=O>>COC(=O)[C@@H]1CCC[C@H]1O,,CO,,Cl,,val
US20020103170A1,COS(=O)(=O)OC.CSC>>COS(=O)(=O)[O-].C[S+](C)C,,CCOCC,,,,val
US05843975,CCOC(=O)Cl.Nc1noc2cc(OCc3ccccc3)ccc12>>CCOC(=O)Nc1noc2cc(OCc3ccccc3)ccc12,,O,,C1CCOC1,O=C([O-])O.[Na+],val
US20150018328A1,CCOC(=O)c1cccc(C2CC2)n1.N=C(NC(=N)NC1CCC(F)(F)C1)NC1CCC(F)(F)C1>>FC1(F)CCC(Nc2nc(NC3CCC(F)(F)C3)nc(-c3cccc(C4CC4)n3)n2)C1,,CO,,C[O-].[Na+],,val
US20090270435A1,COc1cccc2c1C=CC1(CCN(C(=O)OC(C)(C)C)CC1)O2.O=C(O)C(F)(F)F>>COc1cccc2c1C(=O)CC1(CCNCC1)O2,,ClCCl,,,,val
US20080267887A1,CCC(CC)C(=O)c1cn(-c2ccc(OC(C)C)nn2)c2cnc(-c3c(C)cccc3C)cc12>>CCC(CC)C(O)c1cn(-c2ccc(OC(C)C)nn2)c2cnc(-c3c(C)cccc3C)cc12,,CCO,O,[BH4-].[Na+],,val
US05556864,COc1ccc(CCCCc2ccccc2O)cc1.OCC1CO1>>COc1ccc(CCCCc2ccccc2OCC2CO2)cc1,,ClCCl,O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020099047A1,COc1ccc(CCCN2CCCC[C@@H]2CO)cc1.CS(=O)(=O)Cl>>COc1ccc(CCCN2CCCC[C@@H](Cl)C2)cc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US04420487,Cc1ccc(CC#N)cc1.Nc1cc(Cl)c(S(N)(=O)=O)cc1N>>Cc1ccc(Cc2nc3cc(Cl)c(S(N)(=O)=O)cc3[nH]2)cc1,,Cl,,,,val
US20100144730A1,CC(C)(C)OC(=O)NCc1cccc(-c2cn(S(=O)(=O)c3ccccc3)c3nccc(Cl)c23)c1>>NCc1cccc(-c2cn(S(=O)(=O)c3ccccc3)c3nccc(Cl)c23)c1,,CCOC(C)=O,Cl,,,val
US20120258950A1,C[C@@H](CO[Si](C)(C)C(C)(C)C)n1ccc2cncnc21.O=C1CCC(=O)N1I>>C[C@@H](CO[Si](C)(C)C(C)(C)C)n1cc(I)c2cncnc21,,CC#N,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US05438052,CC(=O)Oc1ccc(-c2cnc(-c3ccccc3)nc2Cl)cc1OC(C)=O.S>>Oc1ccc(-c2cnc(-c3ccccc3)[nH]c2=S)cc1O,,CO,,O,[Na],val
US20150291563A1,CC1(C)OB(c2ccc(C3CC(C(O)(C(F)(F)F)C(F)(F)F)=NN3c3ccc(F)cc3F)cc2)OC1(C)C.Cc1ncccc1Br>>Cc1ncccc1-c1ccc(C2CC(C(O)(C(F)(F)F)C(F)(F)F)=NN2c2ccc(F)cc2F)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US05298652,CCCCCCCCCCCCCCCCCCOc1cc(OCc2ccccc2)cc(C(=O)OC)c1>>CCCCCCCCCCCCCCCCCCOc1cc(OCc2ccccc2)cc(C(=O)O)c1,,C1COCCO1,CO,[Na+].[OH-],,val
US20090143353A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1c(-c2ccccc2)c(F)c2oc(C(N)=O)nc2c1C#N>>Cc1c(-c2ccccc2)c(F)c2oc(C(N)=S)nc2c1C#N,,Cc1ccccc1,,,,val
US20090099187A1,O=C(N[C@H]1COc2ccccc2C1)C(F)(F)F.O=S(=O)(Cl)Cl>>O=C(N[C@H]1COc2ccc(Cl)cc2C1)C(F)(F)F,,CC(=O)O,,O=C([O-])O.[Na+],,val
US20100197715A1,COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1(c2ccccc2)CC(=O)CN(C)C1>>COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1(c2ccccc2)CC(O)CN(C)C1,,CO,,[BH4-].[Na+],,val
US20070004753A1,COC(=O)Cc1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C23CCC3)cc1>>N#Cc1ccc(N2C(=O)C3(CCC3)N(c3ccc(CC(=O)O)cc3)C2=S)cc1C(F)(F)F,,CO,,[Na+].[OH-],,val
US09278944B2,COc1ccc(C(C)N(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CCO2)C2CC2)cc1C#CCNC(=O)OCc1ccccc1>>COc1ccc(C(C)N(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CCO2)C2CC2)cc1CCCN,[Pd],CO,,,,val
US20050165065A1,BrC(c1ccccc1)c1ccccc1.CN(CC(=O)N(c1ccccc1)c1ccccc1)[C@@H]1CCNC1>>CN(CC(=O)N(c1ccccc1)c1ccccc1)[C@@H]1CCN(C(c2ccccc2)c2ccccc2)C1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060264415A1,O=C(COCc1ccc(F)cc1)NCCCc1ccc(CN[C@H](CO)Cc2c[nH]c3ccccc23)cc1.OCCBr>>O=C(COCc1ccc(F)cc1)NCCCc1ccc(CN(CCO)[C@H](CO)Cc2c[nH]c3ccccc23)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05338719,CN1C(=O)C(C)(C(=O)CO)Oc2cc(Oc3c(F)cc(C(F)(F)F)cc3Cl)ccc21.Cl>>CN1C(=O)C(C)(C(=O)CCl)Oc2cc(Oc3c(F)cc(C(F)(F)F)cc3Cl)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130197026A1,Cc1cc2cccnc2[nH]1.ClCCN1CCOCC1>>Cc1cc2cccnc2n1CCN1CCOCC1,,CS(C)=O,,Cl,[K+].[OH-],val
US04263299,Clc1ccc(CN2CCNCC2)cc1.OCCCl>>ClCCN1CCN(Cc2ccc(Cl)cc2)CC1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20030083365A1,NCCCN1CCCNC1=S.O=C(O)C(=O)O.O=CC1CCc2ccccc2O1>>O=C(O)C(=O)O.S=C1NCCCN1CCCNCC1CCc2ccccc2O1,[Pd],CO,,,,val
US20120108583A1,CC1(C)Cc2c(c(C(=O)Nc3ccc(C(F)(F)F)cc3)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1.O=P(O)(O)O>>CC1(C)Cc2c(c(C(=O)Nc3ccc(C(F)(F)F)cc3)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1.O=P(O)(O)O,,CC(C)=O,,,,val
US20130150407A1,COC(=O)Cc1cc2ccc(F)cc2c(C2CCN(S(=O)(=O)C3CCCC3)CC2)c1C>>Cc1c(CC(=O)O)cc2ccc(F)cc2c1C1CCN(S(=O)(=O)C2CCCC2)CC1,,C1CCOC1,O,[Li+].[OH-],,val
US20090029955A1,CCO.CCc1nc2sc3c(Cl)ncnc3c2c2c1CCC(C)(C)C2NC.NCCN1CCOCC1>>CCN(C)c1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2c1CCC(C)(C)C2,,CCO,,,,val
US20120309738A1,CNc1cc(N2CCN(C)CC2)c(Cl)cc1N.O=C(NCc1ccc(Cl)c(N=C=S)c1)C1(C(F)(F)F)CC1>>CN1CCN(c2cc3c(cc2Cl)nc(Nc2cc(CNC(=O)C4(C(F)(F)F)CC4)ccc2Cl)n3C)CC1,,CC#N,,ClCCCl,,val
US20140296229A1,CI.CN1C(=O)c2ccc(Br)cc2C1c1ccccc1>>CN1C(=O)c2ccc(Br)cc2C1(C)c1ccccc1,,C1CCOC1,CO,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20070140970A1,C(=NC1CCCCC1)=NC1CCCCC1.CC(=O)CCC(=O)O>>O=C(NC1CCCCC1)NC1CCCCC1,,ClCCl,,,,val
US06492403B1,Br.C[Si](C)(C)C=[N+]=[N-].Cc1oc(C(C)(C)C)cc1C(=O)Cl>>Cc1oc(C(C)(C)C)cc1C(=O)CBr,,CC#N,,CC(=O)O,,val
US20090137564A1,CO.COc1ccc(C(Nc2cc(F)cc3[nH]c(=O)ccc23)C2(C(F)(F)F)CO2)c(Cl)c1F>>COCC(O)(C(Nc1cc(F)cc2[nH]c(=O)ccc12)c1ccc(OC)c(F)c1Cl)C(F)(F)F,,CO,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070072853A1,CC(=O)OCC(=O)Cl.COC(C)(C)c1nc2cc(N(C)S(=O)(=O)c3ccc(N)cc3)ccc2n1CC1CCOCC1>>COC(C)(C)c1nc2cc(N(C)S(=O)(=O)c3ccc(NC(=O)COC(C)=O)cc3)ccc2n1CC1CCOCC1,CN(C)c1ccncc1,CC#N,,,,val
US20110130398A1,CC(C)(C)CC1NC(C(=O)Nc2ccc(C#N)cc2)C(c2cccc(Cl)c2F)C12C(=O)Nc1cc(Cl)c(F)cc12.OO>>CC(C)(C)CC1NC(C(=O)Nc2ccc(C(N)=O)cc2)C(c2cccc(Cl)c2F)C12C(=O)Nc1cc(Cl)c(F)cc12,,CS(C)=O,,[Na+].[OH-],,val
US05958944,O=C(NCc1ccc(C(=O)O)cc1)OCc1ccccc1.O=S(Cl)Cl>>O=C(NCc1ccc(C(=O)Cl)cc1)OCc1ccccc1,CN(C)C=O,ClCCl,,,,val
US20040171606A1,Cn1c(SCCCC2OCC(C)(C)CO2)nnc1-c1ccc2ncccc2c1>>Cn1c(SCCCC=O)nnc1-c1ccc2ncccc2c1,,O,,O=S(=O)(O)O,O=C([O-])[O-].[Na+].[Na+],val
US20080139505A1,C=C(c1ccc(COc2ccc(C(C)=O)c(O)c2CCC)cc1)c1cccc(C#N)c1>>CCCc1c(OCc2ccc(C(C)c3cccc(C#N)c3)cc2)ccc(C(C)=O)c1O,O=[Pt]=O,CCOC(C)=O,,,,val
US20080176829A1,CC(C)(C)OC(=O)N1CCOc2ccc3[nH]ccc3c2C1.Cc1cc(S(=O)(=O)Cl)c(C)s1>>Cc1cc(S(=O)(=O)n2ccc3c4c(ccc32)OCCNC4)c(C)s1,,CO,N,CN(C)C=O,[H-].[Na+],val
US20100173889A1,COC(=O)C1(NS(=O)(=O)c2c(C)cc(OC)cc2C)CCC1>>COc1cc(C)c(S(=O)(=O)NC2(CO)CCC2)c(C)c1,,C1CCOC1,,[H-].[Na+],,val
US20100298301A1,CCOC(=O)c1nc(-c2c(F)cccc2F)oc1OCC>>CCOc1oc(-c2c(F)cccc2F)nc1C(=O)O,,[K+],[OH-],Cl,,val
US20040018942A1,CI.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(C(=O)NN=C(C(C)(C)C)C(C)(C)C)c(Cl)cc2F)c1=O>>CN(N=C(C(C)(C)C)C(C)(C)C)C(=O)c1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160068515A1,ClCCN1CCOCC1.O=c1[nH]ncn1-c1ccc(Br)cc1F>>O=c1n(-c2ccc(Br)cc2F)cnn1CCN1CCOCC1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20120232265A1,C[Si](C)(C)OC1(C#CC(=O)c2ccncc2)CCCC1>>O=C(C#CC1(O)CCCC1)c1ccncc1,,ClCCl,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US06110962,CI.Oc1cc(-c2c3ccccc3c(Br)c3sc4ccccc4c23)cc(Br)c1O>>COc1c(O)cc(-c2c3ccccc3c(Br)c3sc4ccccc4c23)cc1Br,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070219186A1,CI.O=C(O)c1ccnc(Cl)c1>>COC(=O)c1ccnc(Cl)c1,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20020133015A1,CI.O=c1[nH]cccc1Br>>Cn1cccc(Br)c1=O,,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20070236137A1,COc1ccc2c(c1)CCC1=C2CCc2cc(OC)ccc21>>COc1ccc2c(ccc3c4ccc(OC)cc4ccc23)c1,[Pd],,,,,val
US20040053891A1,COC(=O)/C=C/c1cn([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2F)c(=O)[nH]c1=O>>O=C(O)/C=C/c1cn([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2F)c(=O)[nH]c1=O,,O,,CCOCC,[Na+].[OH-],val
US05972943,CC(=O)N1CCN(C(C)C)CC1>>CC(C)N1CCNCC1,,CO,,[K+].[OH-],,val
US05342846,C#C.CC(C)(C)OC(=O)N1C[C@@H](O)[C@H](N=[N+]=[N-])C1>>CC(C)(C)OC(=O)N1C[C@@H](O)[C@H](n2ccnn2)C1,,CC(C)=O,,,,val
US20090181964A1,O=C(C=C1Nc2ccccc2N1)c1cccc(F)c1.O=C(Cl)c1ccc(F)c(S(=O)(=O)Cl)c1>>O=C(C(C(=O)c1ccc(F)c(S(=O)(=O)Cl)c1)=C1Nc2ccccc2N1)c1cccc(F)c1,,C1COCCO1,,,,val
US20130172331A1,CC(C)(C)OC(=O)c1ncc(C(F)F)cc1[N+](=O)[O-]>>O=C(O)c1ncc(C(F)F)cc1[N+](=O)[O-],,ClCCl,O=C(O)C(F)(F)F,Cc1ccccc1,,val
US20110269652A1,CCCCCCCCCCOCC(COCCCCCCCCCC)(CC(=O)N(C)C)CC(=O)N(C)C>>CCCCCCCCCCOCC(CCN(C)C)(CCN(C)C)COCCCCCCCCCC,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120184508A1,CC(C)(C)OC(=O)NC1CCC(Nc2ncc3c(-c4cccc(NCc5ccccc5Cl)c4)nn(COCC[Si](C)(C)C)c3n2)CC1>>NC1CCC(Nc2ncc3c(-c4cccc(NCc5ccccc5Cl)c4)n[nH]c3n2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05686478,CCCc1cc(C(=O)OC)ccc1C=O>>CCCc1cc(C(=O)OC)ccc1CO,,CO,,[BH4-].[Na+],,val
US05430062,COc1cc(/C=C/c2ccc([N+](=O)[O-])cc2)cc(OC)c1OC>>COc1cc(CCc2ccc(N)cc2)cc(OC)c1OC,[Pd],CCOC(C)=O,,,,val
US20160039757A1,CC(C)(C(=O)OCc1ccccc1)c1cccc(Oc2cc(N)cc(C(F)(F)F)c2)c1.O=C(Cl)OCC(Cl)(Cl)Cl>>CC(C)(C(=O)OCc1ccccc1)c1cccc(Oc2cc(NC(=O)OCC(Cl)(Cl)Cl)cc(C(F)(F)F)c2)c1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US05146025,C=C(C)CCc1ccc(-c2ccc(C)cc2)cc1>>Cc1ccc(-c2ccc3cc(C)ccc3c2)cc1,,Cc1ccccc1,,,,val
US07728014B2,CCOC(=O)C(=CC=Cc1ccc(CC)cc1)N=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccccn1>>CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccccn2)n1,,CC#N,,,,val
US20040002524A1,CC(C)NC(=O)c1ccc(-c2nc3ccccc3n2-c2ccc(OCc3ccccc3)cc2)cc1>>CC(C)NC(=O)c1ccc(-c2nc3ccccc3n2-c2ccc(O)cc2)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US20080114005A1,CC(=O)Nc1ccc(O)cc1.CCCc1nn(C)c2c(=O)n(CCCl)c(CC)nc12>>CCCc1nn(C)c2c(=O)n(CCOc3ccc(NC(C)=O)cc3)c(CC)nc12,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20160158207A1,CC(=O)N1CCc2c(c(N3CCCc4c(Cl)cccc43)nn2[C@H]2CCOC2)C1.O=C1CCC(=O)N1Br>>CC(=O)N1CCc2c(c(N3CCCc4c3ccc(Br)c4Cl)nn2[C@H]2CCOC2)C1,,ClCCl,,,,val
US04111934,CC(=O)NN.O=NCNC1=Nc2ccc(Cl)cc2N(c2ccccc2)C(=O)C1>>Cc1nnc2n1-c1ccc(Cl)cc1N(c1ccccc1)C(=O)C2,,CCCCO,,CCN(CC)CC,,val
US06239151B1,CC(C)C[C@@H](C(=O)NN(C[C@@H](C)N1C(=O)c2ccccc2C1=O)c1ccccc1)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1>>CC(C)C[C@@H](C(=O)NN(C(=O)[C@@H](C)N)c1ccccc1)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1,,CO,,NN,O,val
US20060287341A1,NN.Nc1c(Cl)ncnc1Cl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Nc1c(Cl)ncn2c(=O)[nH]nc12,,C1CCOC1,,O,,val
US04104182,CC=CC1(C=CC)C(=O)N(O)C(=O)C1(C=CC)C=CC.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CC=CC1(C=CC)C(=O)N(OC(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)C1(C=CC)C=CC,,CN(C)C=O,,CCN(CC)CC,,val
US20110305776A1,CCOC(=O)CNC(=O)c1c(O)c2cc(Cl)cc(Br)c2sc1=O.C[Sn](C)(C)C>>CCOC(=O)CNC(=O)c1c(O)c2cc(Cl)cc(C)c2sc1=O,,CCOC(C)=O,CN(C)C=O,,,val
US20140005212A1,C=CC(=O)Cl.Nc1cccc(Br)n1>>C=CC(=O)Nc1cccc(Br)n1,,O,,CCN(CC)CC,ClCCl,val
US20140088028A1,CNC[C@H]1O[C@@H]2SC(N(C)C(=O)OC(C)(C)C)=N[C@@H]2[C@@H](O)[C@@H]1O.Cl>>CNC[C@H]1O[C@@H]2SC(NC)=N[C@@H]2[C@@H](O)[C@@H]1O.Cl,,CO,,,,val
US20070105904A1,C#Cc1ccc(N)nc1N.ON=C(Cl)Cc1ccc(Oc2cccc(F)c2)nc1>>Nc1ccc(-c2cc(Cc3ccc(Oc4cccc(F)c4)nc3)no2)c(N)n1,,O,,C1CCOC1,CCN(CC)CC,val
US05041638,BrCCCCOc1ccccc1.OCCc1ccc(O)cc1>>OCCc1ccc(OCCCCOc2ccccc2)cc1,,CC(C)O,,O,O=C([O-])[O-].[K+].[K+],val
US04064279,CSCCC=O.O=Cc1ccccc1>>CSCC(C=O)=Cc1ccccc1,,CO,,[K+].[OH-],,val
US04948800,CC(C)O.CN(C)c1ccc(N(C)C(=O)Cn2c(-c3ccc(Cl)cc3)nc3cccnc32)cc1.[Cl-]>>CN(C)c1ccc(N(C)C(=O)Cn2c(-c3ccc(Cl)cc3)nc3cccnc32)cc1.Cl.O,,CC(C)O,,CC(C)OC(C)C,,val
US20100137278A1,CN1CCC(c2nccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)=CC1=O>>CN1CCC(c2nccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1=O,[Pd],C1COCCO1,CCO,,,val
US20070010670A1,O=C(Cl)c1cc(Cl)c(OCc2ccccc2)c(Cl)c1.c1ccc(COc2cccc3c2NCCO3)cc1>>O=C(c1cc(Cl)c(OCc2ccccc2)c(Cl)c1)N1CCOc2cccc(OCc3ccccc3)c21,,ClC(Cl)Cl,,CCN(CC)CC,O,val
US20160263084A1,CC(=O)Nc1sccc1C(N)=O.O=C1CCC(=O)N1Br>>CC(=O)Nc1sc(Br)cc1C(N)=O,,CC(=O)O,,,,val
US20030040533A1,COC(=O)C=Cc1ccc(OCCn2c(=O)sc3cc(C(=O)c4ccccc4)ccc32)cc1>>COC(=O)CCc1ccc(OCCn2c(=O)sc3cc(C(=O)c4ccccc4)ccc32)cc1,[Pd],C1COCCO1,CO,,,val
US06413955B1,COP(=O)(CC(=O)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C[C@H]1C)OC.COc1ccc(C=O)cn1>>COc1ccc(C=CC(=O)CN2C(=O)[C@@H](NC(=O)OC(C)(C)C)C[C@H]2C)cn1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20070249670A1,CC(C)(C)OC(=O)c1cc(Br)sc1NC(=O)Nc1c(Cl)cccc1Cl.OB(O)c1cccnc1>>CC(C)(C)OC(=O)c1cc(-c2cccnc2)sc1NC(=O)Nc1c(Cl)cccc1Cl,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20080044379A1,COC(=O)C(C)[C@H](NC1(c2ccccc2)c2ccccc2-c2ccccc21)C(=O)OCc1ccccc1>>C[C@H](CO)[C@H](NC1(c2ccccc2)c2ccccc2-c2ccccc21)C(=O)OCc1ccccc1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20100222352A1,BrCc1ccccc1.Oc1cc(Nc2nccs2)ccc1Cl>>Clc1ccc(Nc2nccs2)cc1OCc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080207650A1,CC(C)(C)OC(=O)NCC=O.NC1CCC(n2c(=O)c3cc(F)cnc3n(C3CCSCC3)c2=O)CC1>>CC(C)(C)OC(=O)NCCN[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(C3CCSCC3)c2=O)CC1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110144090A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCn1cc(C2CCCNC2)c2c(O)cc(F)cc21>>CCn1cc(C2CCCN(C(=O)OC(C)(C)C)C2)c2c(O)cc(F)cc21,,ClCCl,,,,val
US20140080840A1,CCOC(=O)N1CCNCC1.OCCCCCBr>>CCOC(=O)N1CCN(CCCCCO)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100240638A1,O=C(N[C@H]1CCCCCCCNC(=O)C(O)C(CC2CCC2)NC(=O)[C@@H]2C[C@@H](OC(=O)N3Cc4cccc(F)c4C3)CN2C1=O)OC1CCCC1>>O=C(N[C@H]1CCCCCCCNC(=O)C(=O)C(CC2CCC2)NC(=O)[C@@H]2C[C@@H](OC(=O)N3Cc4cccc(F)c4C3)CN2C1=O)OC1CCCC1,,CS(C)=O,,,,val
US20160122345A1,CC[C@H]1c2ncc(C(=O)N[C@@H](COC)c3ccc(S(=O)(=O)CC)cc3)cc2CN1C(=O)OC(C)(C)C>>CC[C@@H]1NCc2cc(C(=O)N[C@@H](COC)c3ccc(S(=O)(=O)CC)cc3)cnc21,,ClCCl,,CCOC(C)=O,Cl,val
US20120129883A1,COc1ccccc1C1CCN(C(=O)C(F)(F)F)C1.O=S(=O)(O)Cl>>COc1ccc(S(=O)(=O)Cl)cc1C1CCN(C(=O)C(F)(F)F)C1,,ClCCl,,,,val
US20040214843A1,N.O=C=Nc1cc(F)ccc1F>>NC(=O)Nc1cc(F)ccc1F,,C1CCOC1,,,,val
US04383945,[C-]#[N+][C@]1(C(C)(C)O)C(=O)N2[C@@H]1CCOC2(C)C>>CC(C)(O)[C@H]1C(=O)N2[C@@H]1CCOC2(C)C,,c1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US20150023913A1,BrCc1ccccc1.C=CCC(O)C(=O)OCC>>C=CCC(OCc1ccccc1)C(=O)OCC,,C1CCOC1,CCCCCC,[H-].[Na+],,val
US20160257645A1,CN(C(=O)[C@@H](N)Cc1ccccc1)c1ccc2c(c1)OCO2.Cc1ccccc1S(=O)(=O)N=C=O>>Cc1ccccc1S(=O)(=O)NC(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)c1ccc2c(c1)OCO2,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20040020405A1,O=S(=O)(O)O.O=S(=O)(O)c1ccc2ccc(O)cc2c1>>O=S(=O)(O)c1ccc2cc(S(=O)(=O)O)c(O)cc2c1,,O,,,,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccco2)c1C#N.Cc1ccnc(CO)c1>>Cc1ccnc(COc2nc(N)nc(-c3ccco3)c2C#N)c1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20100286136A1,OC1(C2CC2)CCC2(CC1)OCCO2>>O=C1CCC(O)(C2CC2)CC1,,CC(C)=O,CCOC(C)=O,Cl,O,val
US20140294898A1,NCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.O=C(Cl)c1ccco1>>O=C(N[C@@H](CCNC(=O)c1ccco1)C(=O)O)OCC1c2ccccc2-c2ccccc21,,C1CCOC1,,[Na+].[OH-],,val
US04871765,CNCc1ccc(CSCCN=C(NCC(O)c2ccc(C(N)=O)cc2)NS(C)(=O)=O)o1.O=C(O)C(=O)O>>CNCc1ccc(CSCCNC(=N)N)o1.O=C(O)C(=O)O,,CCO,,,,val
US20140031353A1,COC(=O)C(C(C)=O)C(=O)c1ccc([N+](=O)[O-])cc1.NO>>COC(=O)c1c(C)noc1-c1ccc([N+](=O)[O-])cc1,,CC(=O)O,,Cl,O=C([O-])O.[Na+],val
US20060106058A1,COc1ccc2cc(C(=O)O)c(NCCCNC(=O)OC(C)(C)C)nc2c1>>COc1ccc2cc(C(=O)O)c(NCCCN)nc2c1,,C1COCCO1,Cl,,,val
US20050124654A1,C=Cc1ccc2c(c1)CC[C@@H](NC(=O)OC(C)(C)C)C2>>C=Cc1ccc2c(c1)CC[C@@H](N)C2,,ClCCl,,O=C(O)C(F)(F)F,,val
US04511391,CC(C)=O.Cc1c(C)c(C=O)c2c(c1C)CCO2>>CC(=O)C=Cc1c(C)c(C)c(C)c2c1OCC2,,CC(C)=O,,,,val
US04826866,CCCCCCNC(=S)NN.CCOC(=O)C(Cl)C(C)=O.Cl>>CCCCCCNc1n[nH]c(C)c1C(=O)OCC.Cl,,CCO,,,,val
US05886233,C#C.CC1C(=O)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O[Si](C)(C)C(C)(C)C>>C#CC1(O)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)C1C,,C1CCOC1,,[Li]CCCC,,val
US20040122050A1,COC(=O)CBr.O=C(CC1CCC(c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1)c1ccccc1O>>COC(=O)COc1ccccc1C(=O)CC1CCC(c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110118246A1,CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cccnc1C(=O)O.Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]nc(F)c12>>CO.Cc1cccnc1C(=O)Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]nc(F)c12.N,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20130245002A1,Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(NCCO[Si](C)(C)C(C)(C)C)cc5c4)n3c2)cn1>>Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(NCCO)cc5c4)n3c2)cn1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100041658A1,C=Cc1cc(OC)c(Oc2cccnc2[N+](=O)[O-])cc1F>>CCc1cc(OC)c(Oc2cccnc2N)cc1F,,CO,,C1CCOC1,,val
US20130131061A1,Cc1noc(C)c1-c1c(/C(N)=N/O)c2ccccc2n1-c1ccc(O)cc1F>>Cc1noc(C)c1-c1c(C(=N)N)c2ccccc2n1-c1ccc(O)cc1F,[Pd],CC(=O)O,,CC(=O)OC(C)=O,,val
US06218431B1,CCOC(=O)C1=C(CC)NC(C2CCCC2)=C(C(=O)OC)C1c1ccc(F)cc1>>CCOC(=O)c1c(CC)nc(C2CCCC2)c(C(=O)OC)c1-c1ccc(F)cc1,,ClCCl,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20120101110A1,COCc1cccc(C(=O)O)c1.O=S(Cl)Cl>>COCc1cccc(C(=O)Cl)c1,CN(C)C=O,ClCCl,,,,val
US20110319393A1,C=C(C)C(=O)OC.FC(F)(F)c1ccc(N2CCNCC2)cc1>>COC(=O)C(C)CN1CCN(c2ccc(C(F)(F)F)cc2)CC1,,CCO,,C,C[O-].[Na+],val
US20110230461A1,CCc1ccc(C(C#N)C(=O)OC(C)(C)C)nc1>>CCc1ccc(CC(=O)O)nc1,,O,,Cl,,val
US20140073672A1,COc1ccc(C2=NN(C3CCN(C(=O)c4cc(O)ccc4C)CC3)C(=O)C2(C)C)cc1OC.Clc1cccc(Cl)c1CBr>>COc1ccc(C2=NN(C3CCN(C(=O)c4cc(OCc5c(Cl)cccc5Cl)ccc4C)CC3)C(=O)C2(C)C)cc1OC,,CCO,,[Na+].[OH-],,val
US05576321,ClCCCOc1cccc2[nH]ccc12.O=C(O)C(=O)O.c1ccc2cc(C3CCNCC3)ccc2c1>>O=C(O)C(=O)O.c1ccc2cc(C3CCN(CCCOc4cccc5[nH]ccc45)CC3)ccc2c1,,CCOC(C)=O,,,,val
US20110245205A1,CC(O)c1ncc(-c2cccc(N)c2)s1.FC(F)(F)c1ccnc(Cl)n1>>CC(O)c1ncc(-c2cccc(Nc3nccc(C(F)(F)F)n3)c2)s1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04250183,CCOC(=O)CCN.O=C(O)CCCN(C(=O)c1ccc(Cl)cc1)C(Cc1ccccc1)c1ccccc1>>O=C(O)CCNC(=O)CCCN(C(=O)c1ccc(Cl)cc1)C(Cc1ccccc1)c1ccccc1,,CCO,,[K+].[OH-],,val
US04971981,CC1COCC(CO)O1.CS(=O)(=O)Cl>>CC1COCC(CS(C)(=O)=O)O1,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US06350907B1,COc1cccc(B(O)O)c1.Cc1cc([N+](=O)[O-])ccc1Br>>COc1cccc(-c2ccc([N+](=O)[O-])cc2C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US03976643,CN(C(=N)N)c1c(Cl)cccc1Cl>>CN(C(=N)N)c1c(Cl)cccc1Cl,,[Na+],[OH-],Cl,,val
US20020032186A1,COc1ccc(SC(C)(Cc2ccccc2)C(=O)NO)cc1.OO>>COc1ccc(S(=O)C(C)(Cc2ccccc2)C(=O)NO)cc1,,CO,,,,val
US20150232445A1,CC(C)[Si](Cl)(C(C)C)C(C)C.Oc1ccc(F)c(F)c1>>CC(C)[Si](Oc1ccc(F)c(F)c1)(C(C)C)C(C)C,,CN(C)C=O,O,c1c[nH]cn1,,val
US05688795,COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1>>CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2O)CC1,,CS(C)=O,O,[C-]#N.[Na+],,val
US20100305096A1,C1CN(C2COC2)CC2(CC2)N1.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCN(C4COC4)CC34CC4)n(C)c2n1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04851526,C=CCN.O=CC1CCCC1>>C=CCNCC1CCCC1,,CO,O,Cl,[BH3-]C#N.[Na+],val
US20100093740A1,CCc1nc(Cl)c2n1CCN(C(=O)OC(C)(C)C)C2CCc1ccc(C(F)(F)F)cc1>>CCc1nc(Cl)c2n1CCNC2CCc1ccc(C(F)(F)F)cc1,,ClCCl,,C1COCCO1,Cl,val
US20150065464A1,O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1cnc(Cl)c([N+](=O)[O-])c1>>Nc1cc(C(=O)NC2CCC(=Cc3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cnc1Cl,[Fe],CC(=O)O,,,,val
US20130150325A1,Cc1cc(/C(F)=C/c2ccc(C(C)(C)C(F)(F)F)cc2)n[nH]1.ClCc1ccc(Cl)nc1>>Cc1cc(/C(F)=C/c2ccc(C(C)(C)C(F)(F)F)cc2)nn1Cc1ccc(Cl)nc1,,C1CCOC1,CCOC(C)=O,O,CC(C)(C)[O-].[K+],val
US20060116406A1,CCOC(=O)CC(=O)c1ccccc1.Oc1cccc(O)c1>>O=c1cc(-c2ccccc2)c2ccc(O)cc2o1,,O,,O=S(=O)(O)O,,val
US20110201605A1,C=CCC(C(=O)OC)c1ccc(F)cc1Cl.O=C(OO)c1cccc(Cl)c1>>COC(=O)C(CC1CO1)c1ccc(F)cc1Cl,,ClCCl,,,,val
US06011028,O=C1CCCCCC(CC=Cc2ccccc2)N1>>O=C1CCCCCC(CCCc2ccccc2)N1,[Pd],CO,,,,val
US06627651B1,COC(=O)C1=Cc2cc(OC3CCOCC3)ccc2CCC1>>O=C(O)C1=Cc2cc(OC3CCOCC3)ccc2CCC1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20110281840A1,CC(C)(C)Cc1nc2cc(S(=O)(=O)C3(CO)CCN(C(c4ccccc4)(c4ccccc4)c4ccccc4)CC3)ccc2n1CC1CC1>>CC(C)(C)Cc1nc2cc(S(=O)(=O)C3(CO)CCNCC3)ccc2n1CC1CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150045339A1,CC(C)(C)OC(=O)NCc1nc2ccc(C#C[Si](C)(C)C)cc2[nH]1>>C#Cc1ccc2nc(CNC(=O)OC(C)(C)C)[nH]c2c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150080393A1,CC=NO.CCOC(=O)[C@@H]1CC2(CCN(c3cc(OC(c4ccc(C#N)cc4-n4ccc(C)n4)C(F)(F)F)nc(N)n3)CC2)CN1C(=O)OCc1ccccc1>>CCOC(=O)[C@@H]1CC2(CCN(c3cc(OC(c4ccc(C(N)=O)cc4-n4ccc(C)n4)C(F)(F)F)nc(N)n3)CC2)CN1C(=O)OCc1ccccc1,,Cc1ccccc1,,,,val
US20150361098A1,CC(N)=S.Cc1ccc(S(=O)(=O)N2CC(Br)C(=O)C(C)(C)C2)cc1>>Cc1ccc(S(=O)(=O)N2Cc3sc(C)nc3C(C)(C)C2)cc1,,CCOC(C)=O,CN(C)C=O,,,val
US20140275531A1,COCCN(CCOC)S(F)(F)F.COc1ncc(C(O)c2ccc(F)cc2)cc1-c1cccc(Cl)c1>>COc1ncc(C(F)c2ccc(F)cc2)cc1-c1cccc(Cl)c1,,ClCCl,,,,val
US06166219,CC(=O)Nc1ccc(C(=O)NCc2ccccn2)cc1[N+](=O)[O-]>>CC(=O)Nc1ccc(C(=O)NCc2ccccn2)cc1N,[Pd],CO,,[H][H],,val
US06329405B1,COc1c(OC)c(=O)c1=O.COc1ccc(C(NCC(C)c2ccccc2)c2cccc(N)c2)cc1>>COc1ccc(C(NCC(C)c2ccccc2)c2cccc(Nc3c(OC)c(=O)c3=O)c2)cc1,,CO,,,,val
US20030092677A1,CC(C)(C)OC(=O)Nc1ccc(-c2ccc(F)cc2)cc1NC(=O)CC(=O)c1ccnc(C#N)c1>>N#Cc1cc(C2=Nc3ccc(-c4ccc(F)cc4)cc3NC(=O)C2)ccn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050207972A1,CCN(CC)CCNC(=O)c1ccc(NC(=O)COCc2ccccc2)cc1OC>>CCN(CC)CCNC(=O)c1ccc(NC(=O)CO)cc1OC,[Pd],CO,,,,val
US20050032786A1,C1CCNCC1.CN(C)C=O.CS(=O)(=O)Oc1cccc(-c2nc(=O)c3ccccc3s2)n1>>O=c1nc(-c2cccc(CN3CCCCC3)n2)sc2ccccc12,,CN(C)C=O,O,CCN(CC)CC,CCOC(C)=O,val
US20070265348A1,N#CBr.Nc1ccc2c3c(cccc13)CC2>>N#CNc1ccc2c3c(cccc13)CC2,,CCOC(C)=O,CCOCC,CC#N,,val
US20120157432A1,COC(=O)c1ccc(C#CCC[C@@H](NC(=O)OCc2ccc(OC)cc2)[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(Cl)nc2)cc1>>COC(=O)c1ccc(C#CCC[C@@H](N)[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(Cl)nc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20110015181A1,CC(C)(C)N=C=S.CCC(=O)N(C)N>>CC=CN(C)NC(=S)NC(C)(C)C,,COCCOC,,,,val
US20070197628A1,CC(C)(C)OC(=O)N(CC=Cc1ccc(Cl)cc1)Cc1ccc(F)c(F)c1>>Fc1ccc(CNCC=Cc2ccc(Cl)cc2)cc1F,,C1COCCO1,Cl,O=C([O-])[O-].[K+].[K+],,val
US20100130495A1,Cc1nccn1-c1ccc(Nc2nc3c(c(OS(=O)(=O)C(F)(F)F)n2)CN(C(=O)OC(C)(C)C)CC3)cc1.NCC1CCOCC1>>Cc1nccn1-c1ccc(Nc2nc3c(c(NCC4CCOCC4)n2)CN(C(=O)OC(C)(C)C)CC3)cc1,,CN(C)C=O,,,,val
US20150329538A1,CCn1c(=O)[nH]c2c(Br)c(F)ccc2c1=O.O=P(Cl)(Cl)Cl>>CCn1c(Cl)nc2c(Br)c(F)ccc2c1=O,,O,,CCN(C(C)C)C(C)C,[Na+].[OH-],val
US20050054631A1,CN(C)C=O.O=C1Cc2cccnc2N1c1ccccc1.O=P(Cl)(Cl)Cl>>O=Cc1c(Cl)n(-c2ccccc2)c2ncccc12,,ClCCl,,c1ccncc1,,val
US20100256097A1,CC(C)(C)OC(=O)N1CC=C(OS(=O)(=O)C(F)(F)F)CC1.O=C(Cl)OCc1ccccc1>>O=C(OCc1ccccc1)N1CC=C(OS(=O)(=O)C(F)(F)F)CC1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20060128793A1,CCNCC.COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CC[C@H](O)[C@@]2(C)C[C@H]1OC(C)=O>>CCN(/C=C1/C(=O)O[C@H](COC)[C@@]2(C)C1=C(O)C(=O)C1=C2[C@H](OC(C)=O)C[C@@]2(C)[C@H]1CC[C@@H]2O)CC,,CCOC(C)=O,ClCCl,,,val
US20160002269A1,II.Nc1ccc(C(=O)O)c(O)c1>>O=C(O)c1ccc(I)cc1O,,O,O=S(=O)(O)O,O=N[O-].[Na+],,val
US20150094474A1,CC(=O)OC(C)=O.COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2cc(CNS(C)(=O)=O)ccc2CO)n1>>COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2cc(CNS(C)(=O)=O)ccc2COC(C)=O)n1,,ClCCl,,CCN(CC)CC,,val
US20120208817A1,CON(C)C(=O)c1ccoc1.Cl[Mg]Cc1ccccc1>>O=C(Cc1ccccc1)c1ccoc1,,C1CCOC1,,CCOC(C)=O,[Cl-].[NH4+],val
US20160137637A1,Nc1ccccn1.O=C(O)c1csc(-c2ccc3c(c2)CCO3)n1>>O=C(Nc1ccccn1)c1csc(-c2ccc3c(c2)CCO3)n1,CN(C)c1ccncc1,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05604260,O=[N+]([O-])c1cc2c(cc1Sc1ccc(F)cc1F)C1(CC2)OCCO1>>Nc1cc2c(cc1Sc1ccc(F)cc1F)C(=O)CC2,[Fe],CCO,O,[Cl-].[NH4+],,val
US20100048606A1,COCOCc1cc(OC)nc(C2CC(COS(C)(=O)=O)CN(Cc3ccccc3)C2)c1>>COCOCc1cc2n(c(=O)c1)CC1CC2CN(Cc2ccccc2)C1,,Cc1ccccc1,,,,val
US20120214788A1,COC(=O)C1CC(c2cccc(C(F)(F)F)c2)CN(C(=O)Oc2ccc([N+](=O)[O-])cc2)C1.OC1CNC1>>COC(=O)C1CC(c2cccc(C(F)(F)F)c2)CN(C(=O)N2CC(O)C2)C1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20110269956A1,CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1ncc(-c2ccc(-c3ccc4cc(-c5cnc([C@@H]6C[C@H]7C[C@H]7N6C(=O)OC(C)(C)C)[nH]5)ccc4c3)cc2)[nH]1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.c1cc(-c2c[nH]c([C@@H]3C[C@H]4C[C@H]4N3)n2)ccc1-c1ccc2cc(-c3c[nH]c([C@@H]4C[C@H]5C[C@H]5N4)n3)ccc2c1,,ClCCl,,,,val
US05212324,CCCCC(F)(F)C(=O)CC[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCCCC(=O)OCC(=O)c1ccccc1>>CCCCC(F)(F)C(=O)CC[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCCCC(=O)O,[Zn],CC(=O)O,,,,val
US06174874B1,CCOC(OCC)c1ccc(CC(Cc2ccc(Br)cc2)(C(=O)OC)C(=O)OC)cc1>>CCOC(OCC)c1ccc(CC(CO)(CO)Cc2ccc(Br)cc2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100041891A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)c1cc(F)cc(Br)c1>>CCOC(=O)c1cc(F)cc(B2OC(C)(C)C(C)(C)O2)c1,,CCOC(C)=O,CS(C)=O,ClCCl,CC(=O)[O-].[K+],val
US20150238601A1,CC(N)c1cccc(-c2nccc(Nc3ccc4c(cnn4C(=O)OC(C)(C)C)c3)n2)c1>>CC(N)c1cccc(-c2nccc(Nc3ccc4[nH]ncc4c3)n2)c1,,CO,Cl,,,val
US20090197862A1,N#Cc1cccc(F)c1Cl>>NCc1cccc(F)c1Cl,,C1CCOC1,,B,Cl,val
US06252084B1,COc1cccc2c1c(C(=O)C(N)=O)cn2Cc1ccccc1>>COc1cccc2c1c(C(O)C(N)=O)cn2Cc1ccccc1,,CCO,,[BH4-].[Na+],,val
US20150111734A1,Clc1nn(-c2cccnc2)cc1NCC1CC1.O=C(O)CN1CCCC1=O>>O=C1CCCN1CC(=O)N(CC1CC1)c1cn(-c2cccnc2)nc1Cl,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US20140213591A1,N#Cc1ccc(CN)cc1.O=C(O)c1ccncc1F>>N#Cc1ccc(CNc2cnccc2C(=O)O)cc1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,Cl,val
US20110021518A1,Nc1ccc(-c2c(C(=O)NCC(F)(F)F)cn3ncnc(N)c23)cc1.Nc1ccccc1N.S=C(n1ccnc1)n1ccnc1>>Nc1ncnn2cc(C(=O)NCC(F)(F)F)c(-c3ccc(Nc4nc5ccccc5[nH]4)cc3)c12,,CN(C)C=O,,CC(C)N=C=NC(C)C,,val
US20140235620A1,CC(C)[C@H]1COC(=O)N1c1ccnc(Cl)n1.CC(N)c1ccc(N2CCCCC2)cc1>>CC(Nc1nccc(N2C(=O)OC[C@@H]2C(C)C)n1)c1ccc(N2CCCCC2)cc1,,CCOC(C)=O,CS(C)=O,,,val
US20070185143A1,CCOC(=O)C(=O)C1CC(C)(C)C=C(OC)C1=O.CNN>>CCOC(=O)c1nn(C)c2c1CC(C)(C)CC2=O,,CC(=O)O,O,,,val
US20040171605A1,O=C(O)c1cc(F)ccc1F.OC[C@H]1CCCN1>>O=C1c2cc(F)ccc2OC[C@H]2CCCN12,,CN(C)C=O,O,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20100316601A1,BrB(Br)Br.COc1c(N)cccc1-c1ccc(C(=O)O)o1>>Br.Nc1cccc(-c2ccc(C(=O)O)o2)c1O,,ClCCl,,,,val
US20030055035A1,COC(=O)/C=C(/C)N.O=C1COCC(=O)C1.O=Cc1ccc(Br)c(Br)c1>>COC(=O)C1=C(C)NC2=C(C(=O)COC2)C1c1ccc(Br)c(Br)c1,,CCO,,,,val
US06008230,CS(=O)(=O)Cl.NNc1ccnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc12>>CS(=O)(=O)NNc1ccnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc12,,CN(C)C=O,c1ccncc1,,,val
US04629736,CCCCCCCCCC(=O)NCCCCCC(=O)O.CCCCCCCCCCCCCCCC(O)CC(=O)OC(C)(C)C>>CCCCCCCCCCCCCCCC(CC(=O)OC(C)(C)C)OC(=O)CCCCCNC(=O)CCCCCCCCC,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US07071201B2,C=Cc1ccncc1.c1ccc2c(c1)CCN2C1CCNCC1>>c1ccc2c(c1)CCN2C1CCN(CCc2ccncc2)CC1,,CCO,,,,val
US20060004012A1,CC#CC(CC(=O)OCC)c1ccc(O)cc1.Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1CCl>>CC#CC(CC(=O)OCC)c1ccc(OCc2nc(-c3ccc(C(F)(F)F)cc3)oc2C)cc1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20090099187A1,COc1ccc(S(=O)(=O)Nc2ccccn2)c2c1C[C@@H](NC(=O)C(F)(F)F)CC2>>COc1ccc(S(=O)(=O)Nc2ccccn2)c2c1C[C@@H](N)CC2,,CO,,Cl,[Na+].[OH-],val
US20100137362A1,COC(=O)Cl.Cc1cc(Cl)nc(C(=O)N(N)C(C)C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl>>COC(=O)NN(C(=O)c1nc(Cl)cc(C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl)C(C)C,,c1ccncc1,,,,val
US20050288289A1,COc1cn2ncnc(Oc3ccc([N+](=O)[O-])cc3F)c2c1C>>COc1cn2ncnc(Oc3ccc(N)cc3F)c2c1C,[Zn],C1CCOC1,,CO,[Cl-].[NH4+],val
US05936123,CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)C)cc1C(C)C>>CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)C)cc1C(C)C,,CCO,,ClCCl,,val
US20100069361A1,CC1(C)CC(=O)c2sc(N3CCOc4cc(N)ccc43)nc2C1.O=S(=O)(Cl)c1ccccc1>>CC1(C)CC(=O)c2sc(N3CCOc4cc(NS(=O)(=O)c5ccccc5)ccc43)nc2C1,,ClCCl,,c1ccncc1,,val
US04900728,Cl.N#CSC[C@H]1NC(=O)[C@H]1N1C(=O)c2ccccc2C1=O>>Cl.N#CSC[C@H]1NC(=O)[C@H]1N,,C1COCCO1,,NN,O,val
US20150148334A1,C=CCBr.O=C1NCC(c2ccc(Cl)c(Cl)c2)c2cc(Br)sc21>>C=CCN1CC(c2ccc(Cl)c(Cl)c2)c2cc(Br)sc2C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(O)cc(C)c21.Clc1nsc(Cl)n1>>CCOC(=O)CC1OB(O)c2cc(Oc3nc(Cl)ns3)cc(C)c21,,CN(C)C=O,O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20100311752A1,CC1(C)OB(c2ccc(O)cc2)OC1(C)C.C[C@@H](CO)CBr>>C[C@@H](CO)COc1ccc(B2OC(C)(C)C(C)(C)O2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05760054,CCc1ccc2c(c1)C(=O)N(CCCCO)S2(=O)=O.O=c1oc2ccccc2n1C1CCNCC1>>CCc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O,,O,,,,val
US20130217664A1,CCc1ccccc1Nc1cc2c(cn1)ncn2C.CI>>CCc1ccccc1N(C)c1cc2c(cn1)ncn2C,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US09242991B2,Clc1ncnc2cc3c(cc12)OCCOCCOCCO3.Cn1c(Nc2ccc(F)cc2)ncc(-c2ccc(O)cn2)c1=O>>Cn1c(Nc2ccc(F)cc2)ncc(-c2ccc(Oc3ncnc4cc5c(cc34)OCCOCCOCCO5)cn2)c1=O,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20110230551A1,CC(=O)OC(C)=O.CC1=C(CO)C(=O)O[C@H]([C@@H](C)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C)C1>>CC(=O)OCC1=C(C)C[C@H]([C@@H](C)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C)OC1=O,,c1ccncc1,,CCO,,val
US20080051395A1,C[Si](C)(C)C#Cc1cccc([N+](=O)[O-])c1>>C#Cc1cccc([N+](=O)[O-])c1,,CCOCC,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US05093353,C=CCCCC(=O)CCCC=C.CCCc1c(O)ccc(C(C)=O)c1O>>C=CCCCC1(CCCC=C)CC(=O)c2ccc(O)c(CCC)c2O1,,Cc1ccccc1,,C1CCNC1,,val
US20130237501A1,Br.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc(N)c(F)c3)S(C)(=O)=O)c(C3CC3)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc(Br)c(F)c3)S(C)(=O)=O)c(C3CC3)cc12,,CC#N,,O=N[O-].[Na+],,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccccc4)nc(Cl)c3n2)cc1.Nc1ccc2cn[nH]c2c1>>c1ccc(-c2nc(Nc3ccc4cn[nH]c4c3)c3[nH]ncc3n2)cc1,C1COCCO1,CO,,Cl,,val
US20130096120A1,Cc1c(N)cccc1Br.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>Cc1c(Br)cccc1NC(=O)C12CC3CC(CC(C3)C1)C2,,CCOC(C)=O,,CCN(C(C)C)C(C)C,ClCCl,val
US20030060474A1,CCOC(=O)N1CCN(C(=O)C(CCC(=O)OC(C)(C)C)NC(=O)c2cc(C(=O)NC(CCC(=O)OC(C)(C)C)C(=O)O)c3ccccc3n2)CC1>>CCOC(=O)N1CCN(C(=O)C(CCC(=O)O)NC(=O)c2cc(C(=O)NC(CCC(=O)O)C(=O)O)c3ccccc3n2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120077781A1,CC(C)(C)OC(=O)N1CC[C@H](N)C1.CCOC(=O)CCCCCCn1c2nc(=O)[nH]c(=O)c-2nc2cc(C)c(Cl)cc21>>CCOC(=O)CCCCCCn1c2nc(=O)[nH]c(=O)c-2nc2cc(C)c(N[C@H]3CCN(C(=O)OC(C)(C)C)C3)cc21,,CN1CCCC1=O,,,,val
US20100130474A1,CC(CC(=O)O)CN1CCCCC1.Nc1cc(-c2cncc(F)c2)n[nH]1.O=C(n1ccnc1)n1ccnc1>>CC(CC(=O)Nc1cc(-c2cncc(F)c2)n[nH]1)CN1CCCCC1.O=CO,,ClCCCl,,,,val
US20060004043A1,OCCCN1CCCCC1.Oc1ccc2cc(Br)ccc2c1>>Brc1ccc2cc(OCCCN3CCCCC3)ccc2c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060063759A1,CS(=O)(=O)Nc1cccc(C=C2c3ccccc3CCc3c(F)cccc32)c1>>CS(=O)(=O)Nc1cccc(CC2c3ccccc3CCc3c(F)cccc32)c1,[Pd],CCO,,,,val
US20030119807A1,CN(C)CCN(C)C(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1>>CN(C)CCN(C)C(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)O)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050214287A1,CN1CCCC1CCN.O=Cc1cc2ccccc2[nH]1>>CN1CCCC1CCNCc1cc2ccccc2[nH]1,,ClCCl,,[Na],,val
US20150284358A1,COC(=O)C1(C(C)(C)O)N=C(Br)NC1C(=O)[O-].Clc1ccc(Cl)c(CBr)c1>>COC(=O)c1c(C(C)(C)O)nc(Br)n1Cc1cc(Cl)ccc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110028493A1,CC(C)(C)OC(=O)NN.CCOC(=O)c1cnn(CC(=O)O)c1>>CCOC(=O)c1cnn(CC(=O)NNC(=O)OC(C)(C)C)c1,,ClCCl,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US06703421B1,CCCNC(=O)c1ccc2c(c1)CC(NC(=O)OC(C)(C)C)C2.Cl>>CCCNC(=O)c1ccc2c(c1)CC(N)C2.Cl,,CC(=O)O,,C1COCCO1,,val
US20160229814A1,COC(=O)C(Br)Cc1ccccc1.Nc1ccc([N+](=O)[O-])cc1O>>O=C1Nc2ccc([N+](=O)[O-])cc2OC1Cc1ccccc1,,CN(C)C=O,,[F-].[K+],,val
US04533731,Cl.Nc1n[nH]c2cccc(O)c12>>Cl.Nc1n[nH]c2cccc(O)c12,,CCO,,CCOCC,,val
US20030207886A1,C#C[Si](C(C)C)(C(C)C)C(C)C.Clc1nc2ccccc2nc1Cl>>CC(C)[Si](C#Cc1nc2ccccc2nc1Cl)(C(C)C)C(C)C,[Pd],CC#N,,CCN(CC)CC,,val
US20040236146A1,Cc1c(CC=S(=O)=O)ccc(C(=O)O)c1Cl.O=C1CCC(=O)N1Br>>CCS(=O)(=O)c1ccc(C(=O)O)c(Cl)c1CBr,O=C(OOC(=O)c1ccccc1)c1ccccc1,CC#N,CCOC(C)=O,O=S([O-])O.[Na+],,val
US20070060596A1,NC(=O)c1cc(Cl)ccc1OCc1ccccc1>>NCc1cc(Cl)ccc1OCc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06130237,COc1ccc(CCl)cc1.O=C(O)c1ccc2ccccc2c1O>>COc1ccc(COC(=O)c2ccc3ccccc3c2O)cc1,,CS(C)=O,,[Na],,val
US20050124574A1,CCCC[Sn](CCCC)(CCCC)c1nc(NCC(c2ccccc2)c2ccccc2)c2ncn([C@@H]3O[C@H](CO[Si](C)(C)C(C)(C)C)[C@H]4OC(C)(C)O[C@H]43)c2n1.II>>CC1(C)O[C@@H]2[C@@H](CO[Si](C)(C)C(C)(C)C)O[C@@H](n3cnc4c(NCC(c5ccccc5)c5ccccc5)nc(I)nc43)[C@@H]2O1,,CCOC(C)=O,,C1CCOC1,,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4ccc(-c5ccccc5)nc4nn23)CC1.Cl>>Cl.O=c1cc(C2CCNCC2)n2nc3nc(-c4ccccc4)ccc3c2[nH]1,,C1COCCO1,CO,,,val
US20120196848A1,CC1CN(C(=O)OC(C)(C)C)Cc2scc(Br)c2O1.OB(O)c1cccc(F)c1>>CC1CN(C(=O)OC(C)(C)C)Cc2scc(-c3cccc(F)c3)c2O1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20160194328A1,NC1CC1.Nc1ncnc2c1nc(Sc1cc(Cl)cc(Cl)c1)n2CCBr>>Nc1ncnc2c1nc(Sc1cc(Cl)cc(Cl)c1)n2CCNC1CC1,,CN(C)C=O,,,,val
US20060292079A1,CCC(NC(=O)c1ccn(CCOC)c(=O)c1OCc1ccccc1)(C(=O)[O-])C(=O)N(CCNC(=O)c1ccn(CCOC)c(=O)c1OCc1ccccc1)CCNC(=O)c1ccn(CCOC)c(=O)c1OCc1ccccc1>>CCC(NC(=O)c1ccn(CCOC)c(=O)c1O)(C(=O)O)C(=O)N(CCNC(=O)c1ccn(CCOC)c(=O)c1O)CCNC(=O)c1ccn(CCOC)c(=O)c1O,,CC(=O)O,,Cl,,val
US05378689,O=C(C[C@@H](Cc1ccccc1)C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1)N1CCOCC1>>O=C(O)[C@@H](CC(=O)N1CCOCC1)Cc1ccccc1,,C1CCOC1,O,[Li+].[OH-],,val
US20100063049A1,C1CC2CC1NN2.Cl.Cl>>Cl.Cl.N[C@H]1CC[C@@H](N)C1,[Pt],CCO,O,,,val
US20090298900A1,CCC(NC(=O)CN)C(=O)O.S=C(n1ccnc1)n1ccnc1>>CCC(C(=O)O)N1C(=O)CNC1=S,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20100256127A1,COC(=O)c1ccc(OCc2c(-c3ccc(F)c(F)c3)noc2CO)nc1.NCC1CC1>>O=C(NCC1CC1)c1ccc(OCc2c(-c3ccc(F)c(F)c3)noc2CO)nc1,,C1COCCO1,,C[Al](C)C,,val
US20130178460A1,Cc1nc(NC(=O)c2csc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)OC(C)(C)C)nc23)ccc1C#N>>Cc1nc(NC(=O)c2csc3cnc(N[C@@H]4CCCC[C@@H]4N)nc23)ccc1C#N,,ClCCl,O=C(O)C(F)(F)F,,,val
US20020102590A1,COC(=O)c1ccc(Br)c(C(=O)OC)c1.N#C[Cu]>>COC(=O)c1ccc(C#N)c(C(=O)OC)c1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20120172351A1,COC(=O)C[C@@H]1COc2cc(NCc3cccc(-n4c([C@H]5CCCO5)nc5cc(Cl)ccc54)c3C)ccc21>>Cc1c(CNc2ccc3c(c2)OC[C@H]3CC(=O)O)cccc1-n1c([C@H]2CCCO2)nc2cc(Cl)ccc21,,C1CCOC1,CO,[Na+].[OH-],,val
US20130281438A1,NC1CCCCC1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>O=[N+]([O-])c1ccccc1S(=O)(=O)NC1CCCCC1,,ClCCl,,CCN(CC)CC,,val
US20060111375A1,COc1cc2c(Oc3cc4ccccc4nc3C)ccnc2cc1OCCCl.OC1CCNCC1>>COc1cc2c(Oc3cc4ccccc4nc3C)ccnc2cc1OCCN1CCC(O)CC1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20140131663A1,Brc1cccnc1Br.OB(O)c1cccc(Cl)c1O>>Oc1c(Cl)cccc1-c1ncccc1Br,,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20120129854A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cccc2ncccc12>>CC(C)(C)OC(=O)Nc1cccc2ncccc12,,C1CCOC1,,CCN(CC)CC,,val
US04159273,CCCc1c2c(c(N)c3c(=O)cc(C(=O)OCC)oc13)CCCC2.Cl>>CCCc1c2c(c(Cl)c3c(=O)cc(C(=O)O)oc13)CCCC2,,O,,O=N[O-].[Na+],,val
US20080249146A1,BrBr.O=C(Cc1ccccc1)C1CCCCC1>>O=C(C1CCCCC1)C(Br)c1ccccc1,,C1COCCO1,O,,,val
US20090076101A1,C[Si](C)(C)C(F)(F)F.O=Cc1ccc(Br)s1>>OC(c1ccc(Br)s1)C(F)(F)F,,COCCOC,,[Cs+].[F-],,val
US20040087624A1,CCOC(=O)Cc1ccc(N2Cc3c(c(OCC)c4ccccc4c3OCC)C2=O)cc1>>CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)cc1)C2,,O,,CCO,O=C([O-])[O-].[K+].[K+],val
US20160009744A1,CC(C)[Si](OCc1cc(C(=O)c2cc(Cl)ccc2CCO[Si](C)(C)C(C)(C)C)cs1)(C(C)C)C(C)C.[Li]C>>CC(C)[Si](OCc1cc(C(C)(O)c2cc(Cl)ccc2CCO[Si](C)(C)C(C)(C)C)cs1)(C(C)C)C(C)C,,C1CCOC1,,CCOCC,,val
US05776929,Cc1cccc(NC(=O)NC2C(=O)N(Cc3nnn(C(c4ccccc4)(c4ccccc4)c4ccccc4)n3)c3ccccc3N(Cc3nnn(C(c4ccccc4)(c4ccccc4)c4ccccc4)n3)C2=O)c1>>Cc1cccc(NC(=O)NC2C(=O)N(Cc3nnn[nH]3)c3ccccc3N(Cc3nnn[nH]3)C2=O)c1,,CO,,Cl,O,val
US20070281936A1,Cc1cccnc1CN.Nc1nc(C(=O)O)cc(-c2ccco2)n1>>Cc1cccnc1CNC(=O)c1cc(-c2ccco2)nc(N)n1,,CN(C)C=O,,,,val
US20100075994A1,C#CC(=O)OCC.NC1=NC[C@@H](COCc2ccccc2)O1>>O=c1ccn2c(n1)O[C@H](COCc1ccccc1)C2,,CCO,,,,val
US20100068178A1,COC(=O)c1sc([N+](=O)[O-])cc1N=NN(C)C.[NH4+]>>CN(C)N=Nc1cc([N+](=O)[O-])sc1C(N)=O,,C1CCOC1,,O,,val
US20140004044A1,CC(C)(C)OC(=O)Nc1ccncc1CCF>>Nc1ccncc1CCF,,ClCCl,,CO,O=C(O)C(F)(F)F,val
US05089504,C=Cc1cccc2c(Cl)c(C(=O)CCC)cnc12.Cc1cc(O)ccc1N>>C=Cc1cccc2c(Nc3ccc(O)cc3C)c(C(=O)CCC)cnc12,,C1COCCO1,,,,val
US20100303928A1,CCOC(=O)c1nc(I)c2c(-c3ccc(OC)cc3)noc2c1O.OB(O)c1ccccc1>>CCOC(=O)c1nc(-c2ccccc2)c2c(-c3ccc(OC)cc3)noc2c1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160060233A1,CC(C)(C)OC(=O)NC1CCc2cc(-c3ncn(-c4ccc(OC(F)(F)F)cc4)n3)ccc2C1>>NC1CCc2cc(-c3ncn(-c4ccc(OC(F)(F)F)cc4)n3)ccc2C1,,ClCCl,,,,val
US20100022550A1,Fc1cccc(CBr)n1.O=C(NC1CCc2[nH]c3ccc(OC(F)(F)F)cc3c2C1)OCc1ccccc1>>O=C(NC1CCc2c(c3cc(OC(F)(F)F)ccc3n2Cc2cccc(F)n2)C1)OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060003993A1,CC(C)(C)OC(=O)N(CC(=O)O)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1>>CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(NCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21,,O=C(O)C(F)(F)F,,,,val
US04477464,CCOC(=O)C(=O)CCc1ccccc1.NC1COc2ccccc2NC1=O>>CCOC(=O)C(CCc1ccccc1)NC1COc2ccccc2NC1=O,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20080262020A1,CCOCC(=O)NCC(=O)c1ccc2[nH]c3c(cc(-c4ccc(Cl)cc4Cl)c(=O)n3C)c2c1>>CCOCc1ncc(-c2ccc3[nH]c4c(cc(-c5ccc(Cl)cc5Cl)c(=O)n4C)c3c2)o1,,O=S(=O)(O)O,,O,,val
US20140349993A1,CC1(CO)COC1.Nc1cncc(Cl)n1>>CC1(COc2cncc(N)n2)COC1,,CCCCC,,[H-].[Na+],,val
US20070149544A1,CC(C)(C)OC(=O)NC1CCN(c2ccc(Oc3ccccc3)cc2)CC1.Cl>>Cl.NC1CCN(c2ccc(Oc3ccccc3)cc2)CC1,,C1COCCO1,,,,val
US20090264445A1,CC(C)C[C@@H](C(=O)Nc1ccn(C)n1)N1CC(Oc2cccc(CC(C)(C)O)c2)=CC1=O.CC(C)C[C@H](N)C(=O)Nc1cnccn1>>CC(C)C[C@@H](C(=O)Nc1cnccn1)N1CC(Oc2cccc(CC(C)(C)O)c2)=CC1=O,,CC#N,,CCN(C(C)C)C(C)C,,val
US20100130492A1,CC(C)Cn1c(N2CCN[C@H](C)C2)nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc21.C[C@H](O)CC(=O)O>>CC(C)Cn1c(N2CCN(C(=O)C[C@H](C)O)[C@H](C)C2)nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc21,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20110190336A1,CC(C)(C)OC(=O)CBr.CC(C)(C)OC(=O)N1CCC(n2c(=O)[nH]c3cnccc32)CC1>>CC(C)(C)OC(=O)Cn1c(=O)n(C2CCN(C(=O)OC(C)(C)C)CC2)c2ccncc21,,C1CCOC1,,[H-].[Na+],,val
US20090137595A1,CS(=O)(=O)O.Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2F)n(C)n1>>CS(=O)(=O)O.Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2F)n(C)n1,,CCO,,,,val
US20100130492A1,CC(=O)N1CCN(c2nc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3n2CC(F)(F)F)C[C@@H]1C.CS(=O)(=O)O>>CC(=O)N1CCN(c2nc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3n2CC(F)(F)F)C[C@@H]1C.CS(=O)(=O)O,,CO,ClCCl,,,val
US03971819,CCOC(=O)c1cc([N+](=O)[O-])c(Nc2cccc(C)n2)c(S(N)(=O)=O)c1>>Cc1cccc(Nc2c([N+](=O)[O-])cc(C(=O)O)cc2S(N)(=O)=O)n1,,[Na+],[OH-],Cl,O,val
US20130178460A1,Nc1cccc(-n2nccn2)n1.O=C(Cl)c1csc2cnc(Cl)nc12>>O=C(Nc1cccc(-n2nccn2)n1)c1csc2cnc(Cl)nc12,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US20040043987A1,CCC(C)=O.NC(=O)c1ccccc1O>>CCC1(C)NC(=O)c2ccccc2O1,,CCC(C)=O,,,,val
US05872131,CO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1OC(=O)c1cc(Cl)c(N)c2c1OCC2>>CO[C@@H]1CNCC[C@@H]1OC(=O)c1cc(Cl)c(N)c2c1OCC2,,C1CCOC1,Cl,[NH4+].[OH-],,val
US20090275537A1,CN[C@@H](CNC(=O)OCc1ccccc1)COC(=O)Nc1cc2ccccc2cn1.O=C(NCc1cccc(F)c1Cl)Oc1ccc([N+](=O)[O-])cc1>>CN(C(=O)NCc1cccc(F)c1Cl)[C@@H](CNC(=O)OCc1ccccc1)COC(=O)Nc1cc2ccccc2cn1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20090264431A1,CC(C)(C)OC(=O)N1C[C@@H](O)C[C@@H]1COC(=O)C(C)(C)C.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1C[C@@H](OS(C)(=O)=O)C[C@@H]1COC(=O)C(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20100197591A1,CCOC(=O)CCN(C(=O)CC#N)c1ccc(C(O[Si](C)(C)C(C)(C)C)C(C)(C)C)cc1>>CC(C)(C)C(O[Si](C)(C)C(C)(C)C)c1ccc(N2CCC(O)=C(C#N)C2=O)cc1,,CO,,C1CCC2=NCCCN2CC1,,val
US05066680,CCN1CC=C(CNC(C)=O)CC1>>CCN1CC=C(CN)CC1,,CO,,Cl,[Na+].[OH-],val
US05051445,BrCC1CC1.C1CCOC1.Cc1cc(OCCOCC2CC2)ccc1O>>Cc1cc(OCCOCC2CC2)ccc1OCC1CO1,[Pd],,,C1CCNCC1,,val
US20070254912A1,CCN.COc1ccc2c(c1)nc(C(F)(F)F)n2-c1ccc(Br)cn1>>CCNc1ccc(-n2c(C(F)(F)F)nc3cc(OC)ccc32)nc1,[Cu]I,CS(C)=O,O,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US04141995,Cc1cccc(C(=O)Cl)c1O.Clc1ccccc1>>Cc1cccc(C(=O)c2ccc(Cl)cc2)c1O,,Clc1ccccc1,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20120270838A1,CC(=O)N(CCOC(=O)CBr)c1cc(C)c(Br)c(C)c1>>Cc1cc(NCCO)cc(C)c1Br,,CCO,CCOC(C)=O,[Na+].[OH-],,val
US20060122221A1,Brc1ccc2c(NC3CC3)noc2c1.Cc1c(F)cc(C(=O)NC2CC2)cc1B1OC(C)(C)C(C)(C)O1>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(NC3CC3)noc2c1,,CC(C)O,,O=C([O-])O.[Na+],,val
US20160075627A1,CC(C)=CCCc1ccc(/C=C/C=O)c(C)c1>>Cc1cc(CCCC(C)C)ccc1CCC=O,,CCOC(C)=O,,,,val
US06204277B1,COC(=O)C(Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)cc1)C(=O)O.COC(N)=O>>COC(=O)NC(=O)C(Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)cc1)C(=O)OC,,c1ccccc1,,O=S(Cl)Cl,,val
US06387893B1,CN(C)CCCl.N#CC1c2ccccc2CCc2ccccc21>>CN(C)CCC1(C#N)c2ccccc2CCc2ccccc21,,c1ccccc1,,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20050043537A1,COc1cc(NC(=O)C(C#N)=CNc2ccsc2)c(Cl)cc1Cl>>COc1cc(Nc2c(C#N)cnc3ccsc23)c(Cl)cc1Cl,,CC#N,,O=P(Cl)(Cl)Cl,,val
US04032605,CCC(Cl)C(=O)Cl.O=C(OO)c1cccc(Cl)c1>>CCC(Cl)C(=O)OOC(=O)c1cccc(Cl)c1,,ClC(Cl)Cl,,O,O=C([O-])[O-].[Na+].[Na+],val
US20060089348A1,CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)O)CC1.NN1CCCCCC1>>CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)NN2CCCCCC2)CC1,,C1CCOC1,ClCCl,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120230951A1,COC(=O)N[C@H]1CCc2ccn3c2C1C(=O)C[C@H](C(=O)O)C3.O=C(CBr)c1ccc(Br)nc1>>COC(=O)N[C@H]1CCc2ccn3c2C1C(=O)C[C@H](C(=O)OCC(=O)c1ccc(Br)nc1)C3,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080051418A1,CC(C)Oc1nn(CCCO)cc1C(=O)NCc1ccc(Cl)cc1Cl.COC(=O)Cc1cccc(OC)c1O>>COc1cccc(CC(=O)O)c1OCCCn1cc(C(=O)NCc2ccc(Cl)cc2Cl)c(OC(C)C)n1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US04254260,CCOC(=O)Cc1csc(N)n1.CN=C=O>>CCOC(=O)Cc1csc(NC(=O)NC)n1,,CS(C)=O,,O,,val
US20130150361A1,CC(C)(C)c1cc(N)n(-c2cccc(O)c2)n1.OCCOC1CCCCO1>>CC(C)(C)c1cc(N)n(-c2cccc(OCCOC3CCCCO3)c2)n1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070197577A1,CCOC(=O)CC(CC(C)C)(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>CCOC(=O)CC(CC(C)C)(C(=O)O)C(=O)O,,O=C(O)C(F)(F)F,,,,val
US20100074879A1,COC1=C(OC)C(=O)C(C/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CCC=C(C)C)=C(C)C1=O>>COc1c(O)c(C)c(C/C=C(\C)CCC=C(C)C)c(O)c1OC,,CCCCCC,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US05811459,COC(=O)c1ccc(CCCc2ccccc2O)cc1.OCc1cccnc1>>COC(=O)c1ccc(CCCc2ccccc2OCc2cccnc2)cc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050143452A1,CC(C#N)C1Cc2ccc(Cl)c(-c3ccccc3Cl)c2O1>>NCCC1Cc2ccc(Cl)c(-c3ccccc3Cl)c2O1,,C1CCOC1,,B,,val
US20150191419A1,CC(C)(C)OC(=O)C(Br)c1ccccc1.CC(C)(C)OC(=O)NCC(=O)CCC(=O)O>>CC(C)(C)OC(=O)NCC(=O)CCC(=O)OC(C(=O)OC(C)(C)C)c1ccccc1,,CCOC(C)=O,,CCN(CC)CC,,val
US20150141423A1,Cc1nc(-c2cccnc2)sc1-c1ccc2c(n1)C(=O)CCC2.NO>>Cc1nc(-c2cccnc2)sc1-c1ccc2c(n1)C(=NO)CCC2,,CCO,O,Cl,c1ccncc1,val
US20070225271A1,CCI.CCOc1cc(C=O)ccc1C.O=Cc1cc(O)cc(O)c1>>CCOc1cc(C=O)cc(OCC)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140005164A1,CI.COc1ccc2[nH]c(=O)n(C[C@@H]3CC[C@@H](C(=O)N4CCN(c5ncccn5)CC4)CC3)c2c1>>COc1ccc2c(c1)n(C[C@@H]1CC[C@@H](C(=O)N3CCN(c4ncccn4)CC3)CC1)c(=O)n2C,,CN(C)C=O,,[H-].[Na+],,val
US20010039348A1,COC1=C([N+](=O)[O-])C=CC(Br)(OC)C1>>COC1=C(N)C=CC(Br)(OC)C1,[Fe],CC(=O)O,CCO,,,val
US20010001101A1,CCOC(=O)C1C=Nc2c(cccc2[N+](=O)[O-])C1=O.O=P(Cl)(Cl)Cl>>CCOC(=O)c1cnc2c([N+](=O)[O-])cccc2c1Cl,,ClC(Cl)Cl,,N,,val
US20080280906A1,CCNc1cnoc1C.O=C(Cl)C1CC1>>CCN(C(=O)C1CC1)c1cnoc1C,,O,,Cl,ClCCl,val
US20140336185A1,Brc1ccc(-n2cccn2)cc1.Cc1ccc(B(O)O)cc1>>Cc1ccc(-c2ccc(-n3cccn3)cc2)cc1,,C1CCOC1,,CC#N,O=C([O-])[O-].[Na+].[Na+],val
US04362550,O=C1CNC(c2ccccc2)=NN1>>O=c1cnc(-c2ccccc2)n[nH]1,,CCOC(C)=O,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20110178063A1,CC1CNCCO1.O=C(Nc1cc(-c2cccc3[nH]ccc23)cc2c1cnn2S(=O)(=O)c1ccccc1)c1csc(CCl)n1>>CC1CN(Cc2nc(C(=O)Nc3cc(-c4cccc5[nH]ccc45)cc4[nH]ncc34)cs2)CCO1,,CC(C)O,,Cl,[Na+].[OH-],val
US20140336190A1,Cc1noc(C)c1-c1cc(N)c(N)c(S(=O)(=O)NC2CCCC2)c1.O=C(O)CO>>Cc1noc(C)c1-c1cc(S(=O)(=O)NC2CCCC2)c2nc(CO)[nH]c2c1,,Cl,,,,val
US20130216497A1,CC1CC(N(Cc2ccccc2)Cc2ccccc2)CC1C(=O)O.C[C@@H](N)c1ccccc1>>C[C@@H](N)c1ccccc1.C[C@@H]1C[C@H](N(Cc2ccccc2)Cc2ccccc2)C[C@@H]1C(=O)O,,C1CCOC1,,,,val
US20050054704A1,C[C@@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1cnc2n1[C@](C)(Cc1ccc(C#N)cc1)C(=O)N2c1cc(Cl)cc(Cl)c1)C(=O)O>>C[C@@]1(Cc2ccc(C#N)cc2)C(=O)N(c2cc(Cl)cc(Cl)c2)c2ncc(S(=O)(=O)N3CCC[C@H]3C(=O)NCCO)n21,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20100234351A1,COCC(COC)OCCNC(=O)OC(C)(C)C.Cl>>COCC(COC)OCCN.Cl,,C1CCOC1,,,,val
US20130029980A1,Br.Cc1cc(N)c([N+](=O)[O-])cc1C>>Cc1cc(Br)c([N+](=O)[O-])cc1C,[Cu]Br,ClCCl,O,O=N[O-].[Na+],,val
US20110003833A1,CC(C)(C)OC(=O)N1CCC(O)(Cc2cccc(Nc3nccs3)n2)CC1>>OC1(Cc2cccc(Nc3nccs3)n2)CCNCC1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20110077240A1,COCCN(Cc1cnc(-c2cc3nccc(Oc4ccc(NC(=O)CC(=O)Nc5ccccc5F)cc4F)c3s2)n1C)C(=O)OC(C)(C)C>>COCCNCc1cnc(-c2cc3nccc(Oc4ccc(NC(=O)CC(=O)Nc5ccccc5F)cc4F)c3s2)n1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070155803A1,CC(C)(C)OC(=O)NN.CSCC[C@H](NC(=O)OCc1ccccc1)C(=O)O>>CSCC[C@H](NC(=O)OCc1ccccc1)C(=O)NNC(=O)OC(C)(C)C,,C1CCOC1,,O,O=C(n1ccnc1)n1ccnc1,val
US20040106615A1,CN(C)C=CC(=O)c1cccc(C#N)c1.N=C(N)Nc1ccccc1>>N#Cc1cccc(-c2ccnc(Nc3ccccc3)n2)c1,,CC#N,,,,val
US20060293343A1,CCc1c(C)nc(-c2cccs2)nc1Nc1ccc(CC(=O)O)cc1.N>>CCc1c(C)nc(-c2cccs2)nc1Nc1ccc(CC(N)=O)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080287414A1,CON(C)C(=O)C1=NN2c3cc(Cl)ccc3OCC2C1(CCCO)c1ccccc1.C[Mg]Br>>CC(=O)C1=NN2c3cc(Cl)ccc3OCC2C1(CCCO)c1ccccc1,,C1CCOC1,,,,val
US20150361100A1,CC(c1cc2ccccn2c1-c1ccccn1)n1nc(I)c2c(N)ncnc21.CCCC[Sn](CCCC)(CCCC)c1csc(NC(=O)OC(C)(C)C)n1>>CC(c1cc2ccccn2c1-c1ccccn1)n1nc(-c2cnc(NC(=O)OC(C)(C)C)s2)c2c(N)ncnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,[Cl-].[Li+],,val
US20120264737A1,COc1ccc(C2C(C(=O)O)C2C(=O)O)cc1>>COc1ccc(C2C3C(=O)OC(=O)C32)cc1,,CC(=O)OC(C)=O,,,,val
US20030039997A1,O=C(O[C@@H]1[C@H](OC(=O)c2ccccc2)[C@H](OC(=O)c2ccccc2)CO[C@H]1n1cc(CCN2C(=O)c3ccccc3C2=O)c(=O)[nH]c1=O)c1ccccc1>>O=C1c2ccccc2C(=O)N1CCc1cn([C@@H]2OC[C@@H](O)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O,,CO,,O,C[O-].[Na+],val
US06204221B1,O=C(O)c1ncc(Cl)cc1F.O=S(Cl)Cl>>O=C(Cl)c1ncc(Cl)cc1F,,CCCCCC,,[Na+].[OH-],,val
US20160235729A1,COCOC(C)c1ccc(CCOc2ccc(C=O)cc2)nc1.O=C1CSC(=O)N1>>COCOC(C)c1ccc(CCOc2ccc(C=C3SC(=O)NC3=O)cc2)nc1,,CCO,,C1CCNCC1,,val
US20070082284A1,CC(O)(c1cccc(Br)n1)c1cccc(Br)n1.CCN(CC)S(F)(F)F>>CC(F)(c1cccc(Br)n1)c1cccc(Br)n1,,ClC(Cl)Cl,,[Na+].[OH-],,val
US20070010558A1,NC(=O)c1ccc(OC2CCNCC2)nc1.O=Cc1ccccn1>>NC(=O)c1ccc(OC2CCN(Cc3ccccn3)CC2)nc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US07019026B1,CC(C)(C)OC(=O)c1c(N)sc2c1CCOC2CN.COC(=O)c1ccccc1CBr>>CC(C)(C)OC(=O)c1c(N)sc2c1CCOC2CN1Cc2ccccc2C1=O,,CC#N,,CCN(C(C)C)C(C)C,,val
US20020037875A1,CC(C)(C)OC(=O)c1ccc(O)cc1.CC=CCO>>C/C=C/COc1ccc(C(=O)OC(C)(C)C)cc1,,c1ccccc1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05051413,CC(/C=C(/NC=O)C(=O)O)CP(=O)(OC(C)C)OC(C)C.OCc1ccccc1>>C/C(=C\C(NC=O)C(=O)OCc1ccccc1)CP(=O)(OC(C)C)OC(C)C,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130296373A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)[Si](O[C@@H]1[C@@H](Cc2ccccc2)COC[C@H](NC(=O)OC(C)(C)C)C(=O)O[C@H]1C)(C(C)C)C(C)C>>CC(C)[Si](O[C@@H]1[C@@H](Cc2ccccc2)COC[C@H](N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)O[C@H]1C)(C(C)C)C(C)C,CN(C)c1ccncc1,CC#N,,,,val
US06121272,CCCCOc1ccc(S(=O)(=O)Cl)cc1.O=C(O)[C@H]1C[C@@H](O)CN1>>CCCCOc1ccc(S(=O)(=O)N2C[C@H](O)C[C@@H]2C(=O)O)cc1,CN(C)c1ccncc1,C1COCCO1,O,CCN(CC)CC,,val
US20130303551A1,CC(C(=O)Cl)C1(C)OCCO1.NC[C@@H]1CCN(C(=O)C2CC2)C1>>CC(C(=O)NC[C@@H]1CCN(C(=O)C2CC2)C1)C1(C)OCCO1,,ClCCl,,c1ccncc1,,val
US20150119373A1,C=C(C)[C@@H]1CC[C@]2(C(=O)N3CCN(CC)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(C(=O)N3CCN(CC)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1CCOC1,CO,O=C([O-])[O-].[K+].[K+],,val
US20150111885A1,CCS(=O)(=O)c1ccc(F)c(-c2cn(C)c(=O)c3cncn23)c1.OC1CCC(F)(F)CC1>>CCS(=O)(=O)c1ccc(OC2CCC(F)(F)CC2)c(-c2cn(C)c(=O)c3cncn23)c1,,C1CCOC1,,[H-].[Na+],,val
US20140179666A1,C[C@@H]1CN(Cc2ccccc2)[C@@H](CN2CCOCC2)CN1C(=O)OC(C)(C)C>>C[C@@H]1CN[C@@H](CN2CCOCC2)CN1C(=O)OC(C)(C)C,[Pd],CCO,,CC(=O)O,,val
US20080188506A1,O=C1CC(c2cccc(Cl)c2)C2(C(=O)Nc3cc(Cl)ccc32)C(c2ccc(F)c(F)c2)N1>>O=C1Nc2cc(Cl)ccc2C12C(c1cccc(Cl)c1)CCNC2c1ccc(F)c(F)c1,,CO,,[BH4-].[Na+],,val
US20140206706A1,CC(C)(C)OC(=O)c1ccc(C#N)cc1F.CCN>>CCNc1cc(C#N)ccc1C(=O)OC(C)(C)C,,O,,CN(C)C=O,Cl,val
US03990883,COS(=O)(=O)[O-].CSCCC1NC(=O)N(c2ccccc2)C1=O>>CSCCC1C(=O)N(c2ccccc2)C(=O)N1C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040009965A1,CCC(=O)Cc1ccc(OC)cc1NC(=O)OC(C)(C)C>>CCc1cc2ccc(OC)cc2[nH]1,,C1CCOC1,,O=C(O)C(F)(F)F,,val
US20140275111A1,CCOc1cc(-c2ccc(CC(=O)Nc3ccc(CC(C)(C)CO[Si](C)(C)C(C)(C)C)c(C(F)(F)F)c3)c(F)c2)cnc1OCc1ccc(OC)cc1>>CCOc1cc(-c2ccc(CC(=O)Nc3ccc(CC(C)(C)CO)c(C(F)(F)F)c3)c(F)c2)c[nH]c1=O,,Cl,,,,val
US05155113,N#Cc1ccc(OC(=O)c2ccccc2)nc1O.O=C(Cl)c1ccc(Br)cc1>>N#Cc1ccc(OC(=O)c2ccccc2)nc1OC(=O)c1ccc(Br)cc1,,C1COCCO1,,CCN(CC)CC,,val
US20150158879A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1CCC(O)C1>>CC(C)(C)OC(=O)NC1CCC(O)C1,,ClCCl,,,,val
US20070161822A1,Brc1ccc2c(c1)Cc1ccccc1-2.CI.CS(C)=O>>CC1(C)c2ccccc2-c2ccc(Br)cc21,,CS(C)=O,,CCOC(C)=O,CC(C)(C)[O-].[K+],val
US20030162783A1,BrCc1ccno1.CC(C)(C)OC(=O)NN>>CC(C)(C)OC(=O)NNCc1ccno1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20100227864A1,CCOC(=O)c1ccc(-n2cc(Br)c(C#N)n2)cc1.OB(O)c1ccc2c(c1)OCO2>>CCOC(=O)c1ccc(-n2cc(-c3ccc4c(c3)OCO4)c(C#N)n2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20130029954A1,C=C(C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CO>>C=C(C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,CO,ClCCl,C[Si](C)(C)C=[N+]=[N-],,val
US20160122336A1,CC(C)(O)CN.CCN(CC)C(=O)c1nc(C(=O)O)sc1-c1ccc(C(O)(CC)C(F)(F)F)c(Cl)c1Cl>>CCN(CC)C(=O)c1nc(C(=O)NCC(C)(C)O)sc1-c1ccc(C(O)(CC)C(F)(F)F)c(Cl)c1Cl,,ClCCl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070135477A1,COC(=O)c1cccc(N)c1N.O=C(O)c1n[nH]cc1NC(=O)c1c(F)cccc1F>>COC(=O)c1cccc2[nH]c(-c3n[nH]cc3NC(=O)c3c(F)cccc3F)nc12,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US04143138,Cc1ccc(O)cn1.O=c1c(Cl)nsnc1Cl>>Cc1ccc(Oc2nsnc(Cl)c2=O)cn1,,C1CCOC1,,CCN(CC)CC,,val
US05849765,OC1(c2cc3ccccc3s2)CCN(Cc2ccccc2)CC1>>C1=C(c2cc3ccccc3s2)CCN(Cc2ccccc2)C1,,O=C(O)C(F)(F)F,,,,val
US20080176813A1,Nc1ncnc2c1ncn2[C@@H]1C=C[C@H](CO)[C@@H](O)C1>>Nc1ncnc2c1ncn2[C@@H]1CC[C@H](CO)[C@@H](O)C1,[Pd],CO,,,,val
US20030069239A1,COc1cccc(CN)c1.FC(F)(F)c1cc(Cl)nc(-c2cccnc2)n1>>COc1cccc(CNc2cc(C(F)(F)F)nc(-c3cccnc3)n2)c1,,CCO,,,,val
US20120289698A1,CI.O=C(Cc1ccc(F)cc1)N1C(=O)OC[C@@H]1Cc1ccccc1>>C[C@H](C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1)c1ccc(F)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20140302010A1,N#Cc1ccc(-n2cnc3c([N+](=O)[O-])cccc32)cc1>>N#Cc1ccc(-n2cnc3c(N)cccc32)cc1,[Pd],CCO,,,,val
US20020193414A1,Cn1cnc(CCN)c1.O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(NCCCl)ccc1Cl>>Cn1cnc(CCNCCNc2ccc(Cl)c(C(=O)NCC34CC5CC(CC(C5)C3)C4)c2)c1,,CCCCO,,CCN(C(C)C)C(C)C,[I-].[K+],val
US20100168131A1,CC(C)(C)OC(=O)N1C[C@H]2C[C@H]2C[C@H]1CO.O=C1NC(=O)c2ccccc21>>CC(C)(C)OC(=O)N1C[C@H]2C[C@H]2C[C@H]1CN1C(=O)c2ccccc2C1=O,,C1CCOC1,O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US07199137B2,ON=C1CCc2cc(-c3nc(CN4CCNCC4)[nH]c3-c3ccncc3)ccc21>>O=C1CCc2cc(-c3nc(CN4CCNCC4)[nH]c3-c3ccncc3)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110172247A1,Brc1cncc(Nc2cncnc2)c1.CI>>CN(c1cncnc1)c1cncc(Br)c1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20040220186A1,BrCc1ccccc1.O=C(O)Cc1ccccc1O>>O=C(Cc1ccccc1O)OCc1ccccc1,,CN(C)C=O,O,O=C([O-])O.[Na+],,val
US20040087619A1,C#CCN1CC[C@@H](CCC(=O)c2ccnc3ccc(OC)cc23)[C@@H](C(=O)OC)C1.Fc1cc(F)c(F)c(Br)c1>>COC(=O)[C@H]1CN(CC#Cc2cc(F)cc(F)c2F)CC[C@H]1CCC(=O)c1ccnc2ccc(OC)cc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCN(CC)CC,,CCOC(C)=O,O,val
US20060281771A1,COc1cc2ncnc(Cl)c2cc1OC.OC1CCNCC1>>COc1cc2ncnc(N3CCC(O)CC3)c2cc1OC,,CC(C)O,,,,val
US20130261116A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.CNC(=O)c1ccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1F>>CC(=O)c1ccc2nnn(Cc3ccc4ncccc4c3)c2n1,[Pd],Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06476030B1,CCn1ncnc1CO.Cc1ccc(S(=O)(=O)Oc2nn3c(-c4ccccc4F)nncc3c2-c2ccccc2F)cc1>>CCn1ncnc1COc1nn2c(-c3ccccc3F)nncc2c1-c1ccccc1F,,CN(C)C=O,,O,[H-].[Na+],val
US20100168123A1,CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)O.c1cnc2ncnc(N3CCNCC3)c2c1>>O=C(O)NC(Cc1ccccc1)C(=O)N1CCN(c2ncnc3ncccc23)CC1,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06566357B1,O=C1CN(C(=O)Cc2ccc(F)cc2)N(C(=O)OCc2ccccc2)C1>>O=C1CNN(C(=O)Cc2ccc(F)cc2)C1,[Pd],CO,,[H][H],,val
US20110092504A1,COCCO.O=S(=O)(Nc1cc(-c2ccc3nccc(Cl)c3c2)cnc1Cl)c1ccc(F)cc1>>COCCOc1ccnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc12,,CN(C)C=O,,[H-].[Na+],,val
US20090137642A1,CC#N.CCOC(=O)c1ccccc1>>N#CCC(=O)c1ccccc1,,CCOCC,CO,O,C[O-].[Na+],val
US20120077810A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4nc(-c5ccccc5)cn4cc3-c3ccccc3)cc2)CCC1>>NC1(c2ccc(-c3nc4nc(-c5ccccc5)cn4cc3-c3ccccc3)cc2)CCC1,,CO,,Cl,,val
US20020028801A1,CC(C)C[C@@H](C(=O)O)N(C)C.N[C@@H](Cc1ccc(OCc2ccccc2)cc1)CN1CCOCC1>>CC(C)CC(C(=O)NC(Cc1ccc(OCc2ccccc2)cc1)CN1CCOCC1)N(C)C,,CCOCC,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05480899,COc1ccc(N2C(=O)O[C@H](CO)[C@@H]2C)cc1.N#Cc1ccc(F)cc1>>COc1ccc(N2C(=O)O[C@H](COc3ccc(C#N)cc3)[C@@H]2C)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05859239,CCOC(=O)CN1C(=O)C(NC(=O)[C@H](Cc2ccccc2)SC(C)=O)CCCC12CCCC2>>O=C(O)CN1C(=O)C(NC(=O)[C@@H](S)Cc2ccccc2)CCCC12CCCC2,,CO,,[Na+].[OH-],,val
US05366972,BrBr.Cc1cc(N(C)C)nc(Cl)c1C#N>>Cc1c(Br)c(N(C)C)nc(Cl)c1C#N,,CC(=O)O,O,[Na+].[OH-],,val
US20150065519A1,COc1cc(C(C)=O)ccc1[N+](=O)[O-]>>COc1cc(C(C)=O)ccc1N,[Fe],CO,,Cl,,val
US20120295923A1,CC(C)(C)OC(=O)N[C@H]1C=CC(=O)CC1.FC(F)(F)c1ccc([Mg]Br)cc1>>CC(C)(C)OC(=O)N[C@@H]1CCC(=O)C[C@H]1c1ccc(C(F)(F)F)cc1,,C1CCOC1,,,,val
US20140221344A1,CC(C)(C)OC(=O)N1CC(O)C1.O=[N+]([O-])c1cnccc1Cl>>CC(C)(C)OC(=O)N1CC(Oc2ccncc2[N+](=O)[O-])C1,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US05525632,COc1cc(/C=C\c2ccc(C)c([N+](=O)[O-])c2)cc(OC)c1OC>>COc1cc(/C=C\c2ccc(C)c(N)c2)cc(OC)c1OC,[Zn],CC(=O)O,ClCCl,,,val
US20040029932A1,COCOC(CC(C)(C)c1cc(F)ccc1OC)(C(O)Cc1cc(C)cc(C)c1)C(F)(F)F>>COCOC(CC(C)(C)c1cc(F)ccc1OC)(C(=O)Cc1cc(C)cc(C)c1)C(F)(F)F,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20020004511A1,CC(=O)NNC(=O)c1cc2nccc(Cl)c2s1>>Cc1nnc(-c2cc3nccc(Cl)c3s2)o1,,CN(C)C=O,,O=S(Cl)Cl,,val
US20120028961A1,CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(SCc3ccc(CO)cc3)c2CC1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(SCc3ccc(COS(C)(=O)=O)cc3)c2CC1,,ClCCl,O,CCN(CC)CC,,val
US20110237565A1,CC(C)(C)OC(=O)N1CCNCC1.Clc1nccn2nnnc12>>CC(C)(C)OC(=O)N1CCN(c2nccn3nnnc23)CC1,,CCO,,CCN(CC)CC,,val
US20120316161A1,COCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1Cl.Cc1ccc(B(O)O)cc1>>COCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc(C)cc1,,COCCOC,O,CCN(C(C)C)C(C)C,,val
US05236950,C/C(=C\CCl)CCC[C@H](C)CCC[C@H](C)CCCC(C)C.CO>>COC/C=C(\C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C,,CCOC(C)=O,CO,C[O-].[Na+],,val
US20150191434A1,CC(C)(C)OC(=O)C1CC=C(c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C(=O)N4CC(F)(F)C4)ccc23)CC1>>O=C(O)C1CC=C(c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C(=O)N4CC(F)(F)C4)ccc23)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150329538A1,Cc1nc2ccc(F)c(Br)c2[nH]c1=O.NC1CC1>>Cc1nc2ccc(F)c(Br)c2nc1NC1CC1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20110230458A1,CCCCC(=O)C(c1ccc(OC2CCCCC2)cc1)C(O)C(=O)OCC.NN>>CCCCc1n[nH]c(=O)cc1-c1ccc(OC2CCCCC2)cc1,,CC(=O)O,,O,,val
US20070004675A1,CN1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc([N+](=O)[O-])cc5F)c4s3)nc2)CC1>>CN1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc(N)cc5F)c4s3)nc2)CC1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20100022784A1,CCOC(=O)CBr.O=C1C[C@H](c2ccccc2)CN1>>CCOC(=O)CN1C[C@@H](c2ccccc2)CC1=O,,C1COCCO1,,[H-].[Na+],,val
US20120295887A1,Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(C[C@H](O)CN1CCOCC1)CCC2.O=C(O)C[C@H](O)C(=O)O>>Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(C[C@H](O)CN1CCOCC1)CCC2.O=C(O)CC(O)C(=O)O,,CO,,,,val
US20160009744A1,Cc1sc(C2OCCO2)cc1[C@@H]1OCCc2ccccc21>>Cc1sc(C=O)cc1[C@@H]1OCCc2ccccc21,,C1CCOC1,,Cl,,val
US20070197590A1,C=O.CO.COc1ccc(C2CCNCC2)cc1>>COCN1CCC(c2ccc(OC)cc2)CC1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20100261736A1,COc1ccc(B(O)O)cc1.O=C1CCCc2oc(-c3ccccc3)c(Br)c21>>COc1ccc(-c2c(-c3ccccc3)oc3c2C(=O)CCC3)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20100204240A1,Cc1ncccc1Oc1cc(SCC2CC2)cnc1Nc1nc([C@H]2COC3(CCCCC3)O2)ns1>>Cc1ncccc1Oc1cc(SCC2CC2)cnc1Nc1nc([C@H](O)CO)ns1,,CCO,,Cl,,val
US20110081365A1,CCOC(=O)c1ccc2nc(N)c3ncccc3c2c1>>Nc1nc2ccc(C(=O)O)cc2c2cccnc12,,CCO,,[Na+].[OH-],,val
US20020049235A1,COCc1c(-c2ccncc2)[nH]c(-c2ccncc2)c1C(C)=O>>CC(=O)c1c(-c2ccncc2)[nH]c(-c2ccncc2)c1CO,,Cl,,O=C([O-])O.[Na+],,val
US20050131012A1,Cc1cccc(SSc2cccc(C)c2)c1.NC(=O)c1cc2ncccc2[nH]1>>Cc1cccc(Sc2c(C(N)=O)[nH]c3cccnc23)c1,,CN(C)C=O,,,,val
US20140296208A1,CC(C)(C)OC(=O)Nc1ccc(Oc2ccnc(NCc3ccccn3)c2)c2ccccc12>>Nc1ccc(Oc2ccnc(NCc3ccccn3)c2)c2ccccc12,,Cc1ccccc1,ClCCl,O=C(O)C(F)(F)F,,val
US20150165026A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(O)[C@@H]1CCCN1>>CC(C)(C)OC(=O)N1CCCC1C(=O)O,,ClCCl,,CCN(CC)CC,,val
US20160145252A1,Cn1cc(-c2cccc(-c3ncc(-c4cnn(C)c4)c(N[C@H]4CCC[C@@H]5OC(C)(C)O[C@H]45)n3)c2)cn1>>Cn1cc(-c2cccc(-c3ncc(-c4cnn(C)c4)c(N[C@H]4CCC[C@H](O)[C@@H]4O)n3)c2)cn1,,CO,,Cl,,val
US04661512,O=C(Cl)c1ccccc1.O=C1CC[C@@H](C(=O)OCc2ccccc2)N1>>O=C(OCc1ccccc1)[C@@H]1CCC(=O)N1C(=O)c1ccccc1,,c1ccccc1,,[H-].[Na+],,val
US20030018034A1,CC(=O)N1CCN(c2nc(F)cc(N(C)C)n2)CC1.CO>>COc1cc(N(C)C)nc(N2CCNCC2)n1,,CO,,O,C[O-].[Na+],val
US20080275037A1,Cc1ccc(N2CCc3ncnc(Cl)c3C2)c(C#N)c1.N[C@H](CCO)c1ccc(C(F)(F)F)nc1>>Cc1ccc(N2CCc3ncnc(N[C@H](CCO)c4ccc(C(F)(F)F)nc4)c3C2)c(C#N)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20070161685A1,C=C(C)OC(=O)NC(Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(OC)cn1.NCC(F)(F)F>>COc1ccc([C@](Cc2ccccc2)(NC(=O)NCC(F)(F)F)c2cc(F)cc(C(F)(F)F)c2)nc1,,C1CCOC1,,,,val
US20140256715A1,CC1(c2cc(Br)ccc2F)COCC(=O)N1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC1(c2cc(Br)ccc2F)COCC(=S)N1,,C1CCOC1,,,,val
US20100105667A1,COc1ccc(CN2CCN(Cc3ccc(NC(=O)OC(C)(C)C)nc3)C(C)(C)C2)cc1>>COc1ccc(CN2CCN(Cc3ccc(N)nc3)C(C)(C)C2)cc1,,C1COCCO1,CO,Cl,,val
US20130072490A1,Cc1noc(-c2ccc(Br)cc2)c1N.O=C1CCN(Cc2ccccc2)CC1>>Cc1noc(-c2ccc(Br)cc2)c1NC1CCN(Cc2ccccc2)CC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20010049441A1,C1=C(c2c[nH]c3ncccc23)CC2CCCN2C1.O=S(=O)(Cl)c1ccc(F)cc1>>O=S(=O)(c1ccc(F)cc1)n1cc(C2=CCN3CCCC3C2)c2cccnc21,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20030069297A1,CC(C)(C)OC(=O)N1C[C@H](O)C[C@@H]1C(=O)NC1CC1>>O=C(NC1CC1)[C@H]1C[C@@H](O)CN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140008570A1,COCCOCOc1cc(-c2ccc(OCCCOC3CCCCO3)cc2)cc(-c2ccc(OCCCOC3CCCCO3)cc2)c1>>OCCCOc1ccc(-c2cc(O)cc(-c3ccc(OCCCO)cc3)c2)cc1,,CO,O,Cl,,val
US20030176398A1,C1CCNCC1.CC(=O)CC(C)=O.NCC1(CC(=O)O)CCCCC1>>C1CC[NH2+]CC1.CC(=O)C=C(C)NCC1(CC(=O)[O-])CCCCC1,,CO,,,,val
US20090325985A1,Brc1cccc2c1CCNC2.COc1cnc(-n2cnc(C)n2)c2[nH]cc(C(=O)C(=O)O)c12>>COc1cnc(-n2cnc(C)n2)c2[nH]cc(C(=O)C(=O)N3CCc4c(Br)cccc4C3)c12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120022060A1,O=C(Cl)c1ccc(F)cc1.c1ccc(Nc2ccnc3[nH]c4c(c23)CNCC4)cc1>>O=C(c1ccc(F)cc1)N1CCc2[nH]c3nccc(Nc4ccccc4)c3c2C1,,ClCCCl,,CCN(CC)CC,,val
US20150284381A1,CC1CCCC(O)(c2ccnc(Cl)c2)C1>>CC1C=C(c2ccnc(Cl)c2)CCC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140336106A1,COc1ccc([C@@H](O)[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)OCc2ccccc2)cc1>>COc1ccc([C@@H](O)[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)O)cc1,[Pd],C1CCOC1,,,,val
US06051581,CCCCOC(=O)CC1(O)CN2CCC1CC2.NN>>NNC(=O)CC1(O)CN2CCC1CC2,,CO,ClCCl,O=C(O)C(F)(F)F,,val
US05256674,C=CCS.C=O.O=[N+]([O-])C=C1NCCN1Cc1ccc(Cl)nc1>>C=CCSCC(=C1NCCN1Cc1ccc(Cl)nc1)[N+](=O)[O-],,CCO,,,,val
US20030153605A1,BrCc1ccncc1.CCOC(=O)C(NC(C)=O)C(=O)OCC>>CCOC(=O)C(Cc1ccncc1)(NC(C)=O)C(=O)OCC,,CCO,,Br,[Na+].[OH-],val
US05705188,CC(C)(C)O[K].CCCCCCCC/C=C\CCCCCCCCOS(=O)(=O)c1ccc(C)cc1.Cc1ccccc1C.OCC(O)COC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCCCCC/C=C\CCCCCCCCOCC(COC(c1ccccc1)(c1ccccc1)c1ccccc1)OCCCCCCCC/C=C\CCCCCCCC,,Cc1ccccc1C,,,,val
US20130158075A1,CS(=O)(=O)Cl.O=[N+]([O-])c1ccc(-c2cnc(C3CCNCC3)s2)cc1>>CS(=O)(=O)N1CCC(c2ncc(-c3ccc([N+](=O)[O-])cc3)s2)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US07737166B2,CC(N)=S.Cc1c(C(=O)CBr)c(F)c2oc(C3CC3)nc2c1C#N>>Cc1nc(-c2c(C)c(C#N)c3nc(C4CC4)oc3c2F)cs1,,Cc1ccccc1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04309422,CCSP(=O)(Cl)OC.O=Cc1ccc(O)cc1>>CCSP(=O)(OC)Oc1ccc(C=O)cc1,,ClCCl,,CCN(CC)CC,,val
US20130116234A1,CCOC(=O)c1c(C(C)C)nc2c(OC)cc(Cl)cc2c1Cc1ccccc1Cl>>COc1cc(Cl)cc2c(Cc3ccccc3Cl)c(C(=O)O)c(C(C)C)nc12,,CCO,,[Na+].[OH-],,val
US20130274483A1,O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2C1(O)c1cc2c(cc1OCc1ccccc1)OCO2>>O=C1C(c2cc3c(cc2OCc2ccccc2)OCO3)c2ccccc2N1C(c1ccccc1)c1ccccc1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20060257987A1,CCc1ccc(OC)c(-c2cccn2C(=O)OC(C)(C)C)c1>>CCc1ccc(O)c(-c2ccc[nH]2)c1,,ClCCl,,BrB(Br)Br,O,val
US20120259111A1,CC[C@@H](NC(=O)N1CC(=NOc2ccccc2)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1nc(C(=O)OCC(Cl)(Cl)Cl)co1>>CC[C@@H](NC(=O)N1CC(=NOc2ccccc2)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1nc(C(=O)O)co1,[Zn],CC(=O)O,,,,val
US20040259912A1,COC(=O)c1cc(N)ccc1OC(c1ccc(Cl)cc1)c1ccccc1F.COc1ccc(N=C=O)cc1OC>>COC(=O)c1cc(NC(=O)Nc2ccc(OC)c(OC)c2)ccc1OC(c1ccc(Cl)cc1)c1ccccc1F,,C1CCOC1,,,,val
US20060122168A1,CCOC(=O)C(C)C(=O)NCC(F)(F)C(F)(F)F>>CC(C(=O)O)C(=O)NCC(F)(F)C(F)(F)F,,C1CCOC1,O,[Li+].[OH-],,val
US04806558,CC1(C)CCC(C)(C)c2cc(C#Cc3ccc(C#N)cc3)ccc21.O=C(O)C(O)C(O)C(=O)O>>CC1(C)CCC(C)(C)c2cc(C#Cc3ccc(C=O)cc3)ccc21,,CCCCCC,CCOCC,CC(C)C[Al+]CC(C)C.[H-],,val
US20040229862A1,CC(C)(C)OC(=O)N1CCC(O)C(N=[N+]=[N-])CC1>>CC(C)(C)OC(=O)N1CCC(N)C(O)CC1,[Pd],CO,,,,val
US06607791B1,C=C[C@@H]1CC[C@@H](c2cc(F)cc(F)c2)CC1.O=C=O>>C=C[C@@H]1CC[C@@H](c2cc(F)c(C(=O)O)c(F)c2)CC1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US05607956,COC(C)(c1ccoc1)c1oc(C)nc1C.Cl>>C=C(c1ccoc1)c1oc(C)nc1C.Cl,,CCOCC,,,,val
US20060063760A1,CC(C)(C)OC(=O)OC(C)(C)C.CCOC(=O)Cc1c[nH]c2ccccc12>>CCOC(=O)Cc1cn(C(=O)OC(C)(C)C)c2ccccc12,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,,val
US04975451,C=CC(O)(c1ccc(OC(F)(F)F)cc1)C1CC1.O=S(Cl)Cl>>FC(F)(F)Oc1ccc(C(=CCCl)C2CC2)cc1,,ClCCl,,c1ccncc1,,val
US20050187297A1,COC(=O)c1ccccc1N.OCc1ccccc1>>COC(=O)c1cc(Cc2ccccc2)ccc1N,,Cc1ccc(C)cc1,,Cl,O,val
US05789440,CCC(C)c1ccccc1S.O=C1OC(CCc2ccccc2)(c2ccccc2)CC(O)=C1Br>>CCC(C)c1ccccc1SC1=C(O)CC(CCc2ccccc2)(c2ccccc2)OC1=O,,ClCCl,,C1CCNCC1,,val
US20100305096A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.CCC(CC)(C(=O)[O-])C(=O)[O-].c1ccncc1>>CCOC(=O)C(C(=O)OCC)=C1CCN(C(=O)OC(C)(C)C)CC1,Cl[Ti](Cl)(Cl)Cl,ClC(Cl)(Cl)Cl,,C1CCOC1,,val
US06046136,FC(F)(F)c1ccc(Cl)nc1.OO>>[O-][n+]1cc(C(F)(F)F)ccc1Cl,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20090192162A1,OCC1CCCC1.Oc1cc(Br)cc(Br)c1>>Brc1cc(Br)cc(OCC2CCCC2)c1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20100160344A1,Cc1ccn2cc(C[C@@H]3CCCCN3C(=O)OC(C)(C)C)nc2n1.O=C1CCC(=O)N1Cl>>Cc1ccn2c(Cl)c(C[C@@H]3CCCCN3C(=O)OC(C)(C)C)nc2n1,,ClCCl,,,,val
US04314061,CC(=O)OC(C)=O.CCN(CC)CCOc1ccc2cc3ccc(OCCN(CC)CC)c([N+](=O)[O-])c3nc2c1[N+](=O)[O-]>>CCN(CC)CCOc1ccc2cc3ccc(OCCN(CC)CC)c(NC(C)=O)c3nc2c1NC(C)=O,[Pd],CC(=O)OC(C)=O,,[H][H],,val
US20060211737A1,CC(=O)CCl.CC1(C)CC(=O)CC(=O)C1>>CC(=O)CC1C(=O)CC(C)(C)CC1=O,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20070254869A1,CC(=O)OC(C)=O.CC(C)OC(=O)N1CCCC(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(Br)cc21>>CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCCN(C(=O)OC(C)C)c2cc(Br)ccc21,,ClCCl,,c1ccncc1,,val
US20040082563A1,N#Cc1cccc(C2=C(C(=O)Nc3ccc(N4CCCCC4=O)cc3)CCC2)c1>>NCc1cccc([C@H]2CCC[C@H]2C(=O)Nc2ccc(N3CCCCC3=O)cc2)c1,[Ni],N,,,,val
US03975444,C#Cc1cccc(Oc2ccc([N+](=O)[O-])c([N+](=O)[O-])c2)c1>>C#Cc1cccc(Oc2ccc(N)c(N)c2)c1,[Zn],[NH4+],[OH-],C1CCOC1,,val
US20080045526A1,COC(Cc1ccc2c(n1)COC2=C1C(=O)Nc2ccc(F)cc21)OC>>O=CCc1ccc2c(n1)COC2=C1C(=O)Nc2ccc(F)cc21,,C1CCOC1,,O=S(=O)(O)O,,val
US20050070441A1,Cc1cc(O)n[nH]1.O=[N+]([O-])c1cc([N+](=O)[O-])c(F)c(C(F)(F)F)c1>>Cc1cc(Oc2c([N+](=O)[O-])cc([N+](=O)[O-])cc2C(F)(F)F)n[nH]1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20110230493A1,Brc1ccc(Oc2cccc([C@H]3COC4(CCNCC4)C3)c2)nc1.O=C(Nc1cccnn1)Oc1ccccc1>>O=C(Nc1cccnn1)N1CCC2(CC1)C[C@@H](c1cccc(Oc3ccc(Br)cn3)c1)CO2,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US05639768,CC(=O)Oc1ccccc1.CC(C)N(C(=O)c1ccc(OCCCCCOc2ccc(C=NN)cc2)cc1OCC(N)=O)C(C)C>>CC(=O)N=NCc1ccc(OCCCCCOc2ccc(C(=O)N(C(C)C)C(C)C)c(OCC(N)=O)c2)cc1,,ClCCl,,,,val
US20100273779A1,COc1ccc(C[Mg]Br)cc1.O=C1OC(=O)C2CCC12>>COc1ccc(C(=O)C2CCC2C(=O)O)cc1,,C1CCOC1,,,,val
US20130317026A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.Cc1cc(C)c(CNC(=O)c2cc(Br)nc3c2cnn3C(C)C)c(=O)[nH]1>>C=C(OCC)c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C(C)C)c2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20060173043A1,COC(=O)CCC1=CCCN(C)C1=O.NO[K]>>CN1CCC=C(CCC(=O)NO)C1=O,,CCOC(C)=O,CO,CC(=O)O,,val
US20070142362A1,C=O.CCCCC(=O)Cc1ccsc1>>C=C(C(=O)CCCC)c1ccsc1,,CC(=O)O,,C1CCNCC1,,val
US20040097590A1,CCOC(=O)C(C)Br.COc1ccc(O)cc1>>CCOC(=O)C(C)Oc1ccc(OC)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150150893A1,C=C1CC[C@@H]2[C@](C)(CO)[C@H](O)CC[C@@]2(C)[C@@H]1C/C=C1/C(=O)OC[C@H]1O.O=Cc1cccc([N+](=O)[O-])c1>>C=C1CCC2C3(C)COC(c4cccc([N+](=O)[O-])c4)OC3CCC2(C)C1C/C=C1/C(=O)OCC1O,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04113940,CC1C=C(C(=O)O)N2C(=O)C(NC(=O)CC(NC(=O)OC(C)(C)C)c3cccs3)[C@H]2S1>>CC1C=C(C(=O)O)N2C(=O)C(NC(=O)CC(N)c3cccs3)[C@H]2S1,,O=CO,,,,val
US20120329784A1,CNS(=O)(=O)c1cc(N(C)C)cc([N+](=O)[O-])c1>>CNS(=O)(=O)c1cc(N)cc(N(C)C)c1,[Pd],CO,,,,val
US20050209165A1,COP([O-])OC.O=S(=O)(Oc1cccc(Cl)c1)C(F)(F)F>>COP(=O)(OC)c1cccc(Cl)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20120122846A1,C[Si](C)(C)CCOCn1nc(I)c2ccc([N+](=O)[O-])cc21.OB(O)c1ccncc1>>C[Si](C)(C)CCOCn1nc(-c2ccncc2)c2ccc([N+](=O)[O-])cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20130123252A1,COC(=O)c1sc(C#CC(C)(C)C)cc1Br.C[C@]1(CCCO)OCC(C2CCCCC2)NC1=O>>COC(=O)c1sc(C#CC(C)(C)C)cc1N1C(=O)[C@@](C)(CCCO)OC[C@H]1C1CCCCC1,[Cu]I,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20030149018A1,[N-]=[N+]=NCCOc1cccc2c1ccn2S(=O)(=O)c1ccccc1>>NCCOc1cccc2c1ccn2S(=O)(=O)c1ccccc1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040242690A1,CC(C)=CCC/C(C)=C/CC/C(C)=C/C=O.CC/C(C(=O)[O-])=C(/C)C(CC)(CC)P(=O)(O)O.CC[O-]>>CCOC(=O)/C=C(C)/C=C/C=C(\C)CC/C=C(\C)CCC=C(C)C,,CN(C)C=O,,CC(=O)O,,val
US20120252801A1,CCN1CC(C)(C)OC(=O)C1CC(=O)O.NCc1ccco1>>CCN1CC(C)(C)OC(=O)C1CC(=O)NCc1ccco1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04016209,Cl.N#CCCN(C=O)CCCO>>[Cl-].[NH3+]CCCN(C=O)CCCO,[Pt],O,,[H][H],,val
US20090036492A1,COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.O=Cc1ccc(Oc2ccccc2)cc1>>COc1cc(O)c2c(c1C(=O)NCc1ccc(Oc3ccccc3)cc1)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,,Cc1ccccc1,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20050176689A1,CC(C)O.O=C(O)c1cccc(Br)c1>>CC(C)OC(=O)c1cccc(Br)c1,,O,,O=S(=O)(O)O,,val
US20030220350A1,CCOC(=O)CCN.Cc1ccc2c(c1)C(=O)OC2=O>>CCOC(=O)CCN1C(=O)c2ccc(C)cc2C1=O,,CN1CCCC1=O,O,CCN(CC)CC,Cl,val
US20080188528A1,CCOC(C)=N.Cc1ccc(C(c2ccc(C)cc2)c2ccc(C(=O)N[C@@H](CCCN)C(=O)O)s2)cc1.O=C(O)C(F)(F)F>>CC(=N)NCCC[C@H](NC(=O)c1ccc(C(c2ccc(C)cc2)c2ccc(C)cc2)s1)C(=O)O.O=C(O)C(F)(F)F,,CCO,,CCN(CC)CC,Cl,val
US20140248268A1,CC(C)(C)OC(=O)c1c(N)sc2c1CC(C)(C)OC2.S=C=Nc1ccccc1>>CC(C)(C)OC(=O)c1c(NC(=S)Nc2ccccc2)sc2c1CC(C)(C)OC2,,C1CCOC1,,,,val
US20120252780A1,Nc1cccnc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C1CCCNc2nc(-c3cccc(Cl)c3)ccc21>>O=C1CCCN(C(=O)Nc2cccnc2)c2nc(-c3cccc(Cl)c3)ccc21,,C1CCOC1,O,CCN(CC)CC,,val
US04472547,CC(=O)OC(C)=O.CC1(C)CC(N2CCCCCC2=O)CC(C)(C)N1>>CC(=O)N1C(C)(C)CC(N2CCCCCC2=O)CC1(C)C,O=S(=O)(O)O,,,,,val
US20090247746A1,CCOC(=O)c1cc2cccc(N)c2[nH]1.O=S(=O)(Cl)c1ccc(Cl)s1>>CCOC(=O)c1cc2cccc(NS(=O)(=O)c3ccc(Cl)s3)c2[nH]1,,c1ccncc1,,,,val
US20030153568A1,BrBr.CCNC(=O)Nc1nc2ccc(Br)c(O)c2s1>>CCNC(=O)Nc1nc2c(Br)cc(Br)c(O)c2s1,,CC(=O)O,,Cc1ccccc1,,val
US20020099212A1,CC(=O)Nc1nc(Br)ccc1[N+](=O)[O-].N#Cc1ccc(CBr)c(Cl)c1>>CC(=O)N(Cc1ccc(C#N)cc1Cl)c1nc(Br)ccc1[N+](=O)[O-],,CN(C)C=O,,[H-].[Na+],,val
US20020019558A1,O=[N+]([O-])c1ccc(OCC(O)COc2ccc([N+](=O)[O-])cc2)cc1>>Nc1ccc(OCC(O)COc2ccc(N)cc2)cc1,[Pd],C1COCCO1,,C,,val
US20120214804A1,Nc1cccc2nc(-c3ccccc3)[nH]c12.O=C1CCCC1>>c1ccc(-c2nc3cccc(NC4CCCC4)c3[nH]2)cc1,,CC(Cl)Cl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20070185155A1,Clc1cccc(OCCCBr)c1.OC(c1ccccc1)(c1ccccc1)C12CCN(CC1)CC2>>OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3cccc(Cl)c3)(CC1)CC2.[Br-],,CC#N,,,,val
US20100130557A1,CCn1c2ccccc2c2cc(N(CC(=O)OC)S(=O)(=O)c3cc(Cl)cc(Cl)c3)ccc21>>CCn1c2ccccc2c2cc(N(CC(=O)O)S(=O)(=O)c3cc(Cl)cc(Cl)c3)ccc21,,C1CCOC1,,[Na+].[OH-],,val
US04427437,CI.CN(C)c1cccc(Oc2ncc(Cl)cn2)c1>>C[N+](C)(C)c1cccc(Oc2ncc(Cl)cn2)c1.[I-],,CCOCC,,,,val
US20040034034A1,CCOC(=O)C=Cc1nc(C)ccc1OCC(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C>>CCOC(=O)CCc1nc(C)ccc1OCC(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C,O=[Pt],CCO,,,,val
US05811455,COC(=O)C1CC(C#N)(c2ccc(OC(F)F)c(OCC3CC3)c2)CCC1=O.COC(=O)CCC(C#N)(CCC(=O)OC)c1ccc(OC(F)F)c(OCC2CC2)c1>>O=Cc1ccc(OC(F)F)c(OCC2CC2)c1,,COCCOC,,[H-].[Na+],,val
US20040180925A1,N#Cc1cccnc1N1CCC2(CC1)OCCO2>>N#Cc1cccnc1N1CCC(=O)CC1,,CC(C)=O,,Cl,,val
US20060030609A1,CC(C)CN.O=C(O)Cc1cc([N+](=O)[O-])ccc1F>>CC(C)CN1C(=O)Cc2cc([N+](=O)[O-])ccc21,,CS(C)=O,,,,val
US20110275608A1,COc1ccnc(Cl)c1C#N.Oc1ccccc1>>COc1ccnc(Oc2ccccc2)c1C#N,,CC(=O)N(C)C,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US07326791B2,Cc1cc(C(=O)N[C@@H](CCCCN)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1.O=C1CCC(C(=O)O)N1>>Cc1cc(C(=O)N[C@@H](CCCCNC(=O)C2CCC(=O)N2)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20060025432A1,CN1CCNCC1.NS(N)(=O)=O>>CN1CCN(S(N)(=O)=O)CC1,,C1COCCO1,,,,val
US20130137672A1,CC(C)(C)OC(=O)N1CCC2CN(C(=O)c3ccccc3-c3ccccc3)C2C1>>O=C(c1ccccc1-c1ccccc1)N1CC2CCNCC21,,C1COCCO1,,O=C(O)C(F)(F)F,,val
US20050119318A1,Cn1c(-c2ccoc2)c(C2CCCCC2)c2ccc(C(=O)O)cc21.N>>Cn1c(-c2ccoc2)c(C2CCCCC2)c2ccc(C(N)=O)cc21,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20130116235A1,Cn1cc(Br)cc(Nc2ccc(N3C4CCC3CN(C(=O)OC(C)(C)C)C4)cn2)c1=O>>Cn1cc(Br)cc(Nc2ccc(N3C4CCC3CNC4)cn2)c1=O,,C1COCCO1,Cl,,,val
US20140018393A1,O=C(N(CC1CCNCC1)[C@@H]1C[C@H]1c1ccccc1)C(F)(F)F.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)N1CCC(CN[C@@H]2C[C@H]2c2ccccc2)CC1,,ClC(Cl)Cl,,[Cl-].[NH4+],,val
US20120264735A1,C1CCOC1.CCOC(C)=O.Cl.Clc1ncc(OC2CCC3(CC2)OCCO3)cn1>>O=C1CCC(Oc2cnc(-c3cccc(Cl)c3)nc2)CC1,,C1CCOC1,CCOC(C)=O,,,val
US20050054681A1,CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)n1cccn1.CNCCCOc1cc(=O)oc2ccc(Cl)cc12.O=C(O)C(F)(F)F>>N=C(N)NCCCOc1cc(=O)oc2ccc(Cl)cc12.O=C(O)C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150073019A1,CN(C)C=C1C(=O)N(c2nc3ccccc3s2)N=C1c1sccc1Br.N>>NC=C1C(=O)N(c2nc3ccccc3s2)N=C1c1sccc1Br,,CO,N,,,val
US20150057265A1,COC1CCN(Cc2cnc3c(C(=O)Nc4cnccc4N4C[C@H](C(F)(F)F)C[C@H](NC(=O)OC(C)(C)C)C4)c(NC(=O)OC(C)(C)C)oc3c2)C1>>COC1CCN(Cc2cnc3c(C(=O)Nc4cnccc4N4C[C@H](C(F)(F)F)C[C@H](N)C4)c(N)oc3c2)C1,,CO,,C1COCCO1,Cl,val
US20070066595A1,CS(=O)(=O)C1CC=C(c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)CC1.Cl>>CS(=O)(=O)C1CC=C(c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)CC1.Cl,,ClCCl,,,,val
US20040122063A1,C1=CCCCCC1.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>O[C@H]1CCCCC[C@H]1O,O=[Os](=O)(=O)=O,CC#N,,O,,val
US20140155391A1,COC(=O)c1ccc(OCCN2CCOCC2)c(C=O)c1.CON>>CO/N=C/c1cc(C(=O)OC)ccc1OCCN1CCOCC1,,c1ccncc1,,Cl,,val
US20030134840A1,CC(C)(C)OC(=O)N1CCC(Nc2ccc(Cl)c(Cl)c2)CC1.O=C(O)C(F)(F)F>>Clc1ccc(NC2CCNCC2)cc1Cl.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05773446,COc1cc(C=O)c2c(c1OC)OC(C1CC1)C=C2.N#CCCNc1ccccc1>>COc1cc(CC(C#N)=CNc2ccccc2)c2c(c1OC)OC(C1CC1)C=C2,,CS(C)=O,,,,val
US20090181963A1,Nc1ccc(-c2nc(N3CCOCC3)c3nnn(CC(F)(F)F)c3n2)cc1.Nc1cncnc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(Nc1ccc(-c2nc(N3CCOCC3)c3nnn(CC(F)(F)F)c3n2)cc1)Nc1cncnc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20100080771A1,C=Cc1cccc(-c2cccc([C@]3(O)C[C@@H](C(=O)OC)N(C(=O)OCC[Si](C)(C)C)C3)c2)c1.CI>>C=Cc1cccc(-c2cccc([C@]3(OC)C[C@@H](C(=O)OC)N(C(=O)OCC[Si](C)(C)C)C3)c2)c1,,CN(C)C=O,,[H-].[Na+],,val
US05132310,Cc1c(C)c2c(c(C)c1O)CCC(C)(C#Cc1ccccc1N)O2.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1c(C)c2c(c(C)c1O)CCC(C)(C#Cc1ccccc1NC(=O)C(F)(F)F)O2,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US20090286812A1,CC(C)(C)OC(=O)N1CCC(n2ncc3c(Cl)ncnc32)CC1.Cn1nc(O)ccc1=O>>Cn1nc(Oc2ncnc3c2cnn3C2CCN(C(=O)OC(C)(C)C)CC2)ccc1=O,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20060183900A1,CI.O[C@@H]1CC[C@@H](Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1>>Cn1cc(-c2ccnc(N[C@@H]3CC[C@@H](O)CC3)n2)c2cccnc21,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110269788A1,ClCI.O=C1C(c2cc3c(cc2O)OCCO3)c2cccnc2N1C(c1ccccc1)c1ccccc1>>O=C1N(C(c2ccccc2)c2ccccc2)c2ncccc2C12COc1cc3c(cc12)OCCO3,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100093854A1,C[C@H](OC(=O)[C@H](Oc1cccc(C(F)(F)F)c1)c1ccc(Cl)cc1)C(=O)N1CCCC1>>O=C(O)C(Oc1cccc(C(F)(F)F)c1)c1ccc(Cl)cc1,,Cc1ccccc1,,Cl,O,val
US20090247499A1,CI.O=C(Cc1ccc(C(F)(F)F)cc1)N1CCN(S(=O)(=O)c2cc(Cl)cc(Cl)c2)CC1>>CC(C(=O)N1CCN(S(=O)(=O)c2cc(Cl)cc(Cl)c2)CC1)c1ccc(C(F)(F)F)cc1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20160068532A1,COC(=O)c1cc2c(NC(=O)OCc3ccccc3)nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c2cc1Cl.C[C@@H](NC(N)=O)c1ccccc1>>C[C@H](c1ccccc1)n1c(=O)[nH]c2cc3c(cc2c1=O)c(N)nn3C(c1ccccc1)(c1ccccc1)c1ccccc1,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050070582A1,CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2cc(C#N)ccc2S(=O)(=O)c2cc(Cl)cc(Cl)c2)CC1.Cl>>Cl.N#Cc1ccc(S(=O)(=O)c2cc(Cl)cc(Cl)c2)c(S(=O)(=O)N2CCNCC2)c1,,C1COCCO1,,,,val
US20020160996A1,Cc1oc2c(C)c(C)c(N3C(=O)c4ccccc4C3=O)c(C)c2c1-c1ccc(C(C)C)cc1>>Cc1oc2c(C)c(C)c(N3Cc4ccccc4C3)c(C)c2c1-c1ccc(C(C)C)cc1,,CCO,,,,val
US20020160996A1,Cc1c(C)c2c(c(C)c1N)C(c1ccc(C(C)C)cc1)C(C)(C)O2.O=C(Cl)c1ccccc1>>Cc1c(C)c2c(c(C)c1NC(=O)c1ccccc1)C(c1ccc(C(C)C)cc1)C(C)(C)O2,,CCCCCC,CCOC(C)=O,,,val
US20020128270A1,C[C@H]([C@H](COCc1ccccc1)NC(=O)OC(C)(C)C)N(CCOS(C)(=O)=O)S(C)(=O)=O>>C[C@@H]1[C@H](COCc2ccccc2)N(C(=O)OC(C)(C)C)CCN1S(C)(=O)=O,,CN(C)C=O,,Cl,[H-].[Na+],val
US04242121,Cc1cccc(O)c1.O=C(O)c1cc(Cl)ccc1Cl>>Cc1cccc(Oc2ccc(Cl)cc2C(=O)O)c1,[Cu],CO,,[Na],,val
US20060135554A1,CCOc1ccc(Cc2nc3cc(C(=O)OC)cnc3n2CC2CC2)cc1>>CCOc1ccc(Cc2nc3cc(C(=O)O)cnc3n2CC2CC2)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US04180670,C(=Nc1ccncc1)c1cccs1.[Li]CCCC>>CCCCC(Nc1ccncc1)c1cccs1,,CCOCC,,O,,val
US20130079338A1,C[Si](C)(C)CCOCn1c(=O)ccc2cc(CCc3cnc(Nc4ccc(OC(F)F)c(Cl)c4)nc3)ccc21>>O=c1ccc2cc(CCc3cnc(Nc4ccc(OC(F)F)c(Cl)c4)nc3)ccc2[nH]1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160229847A1,CCn1cc(C=O)c2cc(C(F)(F)F)cnc21.NCCO>>CCn1cc(CNCCO)c2cc(C(F)(F)F)cnc21,,CCO,,[BH4-].[Na+],,val
US20120264728A1,C[C@H](O)c1ccnc(N)n1.Oc1cccc(F)c1>>C[C@@H](Oc1cccc(F)c1)c1ccnc(N)n1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110021522A1,Nc1cccc(Br)c1.OB(O)c1cncnc1>>Nc1cccc(-c2cncnc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US05462941,Cl[Mg]C1CCCCC1.O=C1OC(=O)c2ccccc21>>O=C(O)c1ccccc1C(=O)C1CCCCC1,,C1CCOC1,,Cl,,val
US05185363,CCC(O)c1ccc(C)s1>>CC(=O)Cc1ccc(C)s1,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US05650422,C=CCBr.CCOc1ccc(O)c2c1C(=O)N(Cc1ccccc1)S2(=O)=O>>C=CCOc1ccc(OCC)c2c1S(=O)(=O)N(Cc1ccccc1)C2=O,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060116410A1,CCOC(=O)CCl.CNC(=O)COc1cc(C#N)ccc1CNC(=O)c1cc(C)cc(O)c1>>CCOC(=O)COc1cc(C)cc(C(=O)NCc2ccc(C#N)cc2OCC(=O)NC)c1,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060229336A1,CO.Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2ccccc2)CCN(C(=O)c2ccccc2C(=O)O)CC1>>COC(=O)c1ccccc1C(=O)N1CCC(CCN2C3CCC2CC(n2c(C)nc4ccccc42)C3)(c2ccccc2)CC1,,CO,,C[Si](C)(C)C=[N+]=[N-],,val
US20140094462A1,C=CC[C@@H](C)C(=O)O.C=CC[C@H](C)C(=O)N[C@@H](CO)c1cccs1>>C=CC[C@H](C)C(=O)OC[C@@H](NC(=O)[C@@H](C)CC=C)c1cccs1,,ClCCl,,CCCCCC,CCOC(C)=O,val
US20140167002A1,Brc1cnc(Br)c2nsnc12.CCCC[Sn](CCCC)(CCCC)c1cccs1>>Brc1cnc(-c2cccs2)c2nsnc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20120040962A1,C[Mg]I.O=c1c2ccc(Br)cc2oc2ccc(Br)cc12>>C=C1c2ccc(Br)cc2Oc2ccc(Br)cc21,,C1CCOC1,CCOC(C)=O,CC(=O)O,,val
US04122183,Cc1coc(NC(=O)CCCCl)n1>>Cc1coc(N2CCCC2=O)n1,,c1ccccc1,,,,val
US20040127733A1,CC(C)(N)CCn1cnc(I)c1.CCOC(O)C(O)c1ccc(OCc2ccccc2)c(NS(=O)(=O)c2ccccc2)c1>>CC(C)(CCn1cnc(I)c1)NCC(O)c1ccc(OCc2ccccc2)c(NS(=O)(=O)c2ccccc2)c1,,CCO,,CC(=O)O,[BH4-].[Na+],val
US20060020003A1,CCCCc1oc2ccccc2c1C(=O)N(Cc1ccccc1)Cc1ccc(-c2ccc(O)c(Br)c2)cc1.N#CCBr>>CCCCc1oc2ccccc2c1C(=O)N(Cc1ccccc1)Cc1ccc(-c2ccc(OCC#N)c(Br)c2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140378475A1,Cc1c(Br)cccc1NC(=O)c1cc(F)ccc1N.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1c(Br)cccc1-n1c(=O)[nH]c2ccc(F)cc2c1=O,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20030158418A1,C1CCOC1.C1CCOC1.CON(C)C(=O)[C@H](C)NC(=O)[O-].Fc1ccc([Mg]Br)cc1>>C[C@H](NC(=O)OC(C)(C)C)C(=O)c1ccc(F)cc1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20110105463A1,COC(=O)C1CCOc2cc(F)ccc21.O=C1CCC(=O)N1Br>>COC(=O)C1CCOc2cc(F)c(Br)cc21,,CCOC(C)=O,CN(C)C=O,,,val
US20110059948A1,O=C(Cl)c1c(Cl)nc2ccc(Br)cc2c1-c1ccccc1>>O=C1c2ccccc2-c2c1c(Cl)nc1ccc(Br)cc21,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05331084,C1=CCC=C1.C=CC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.CCCCOO>>FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1CC2CC1C1OC21,,Cc1ccccc1,,,,val
US20050130957A1,CCn1nc(C)c2c1C(=O)NCC(c1ccc(OC)cc1)=N2.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCn1nc(C)c2c1C(=S)NCC(c1ccc(OC)cc1)=N2,,Cc1ccccc1,,,,val
US05258380,BrCCBr.CCn1nn[nH]c1=O>>CCn1nnn(CCBr)c1=O,,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20050197326A1,CCOC(=O)CC1Sc2ccccc2NC1=O.O=C(O)CBr>>CCOC(=O)CC1Sc2ccccc2N(CC(=O)O)C1=O,,C1CCOC1,CCOCC,Cl,CC(C)[N-]C(C)C.[Li+],val
US20090054475A1,CC(C)(C)OC(=O)N1CCN(c2nc(COc3ccc(S(C)(=O)=O)cc3)cs2)CC1.Cl>>CS(=O)(=O)c1ccc(OCc2csc(N3CCNCC3)n2)cc1.Cl,,C1COCCO1,CO,,,val
US20080234499A1,COc1ccccc1SC[C@@H](C)C(=O)N[C@@H]1COc2ccccc2SC1>>COc1ccccc1SC[C@@H](C)CN[C@@H]1COc2ccccc2SC1,,C1CCOC1,,B,,val
US06444828B1,CCCC(=O)CC(=O)CC(=O)OCC.CNN>>CCCc1cc(C(=O)OCC)nn1C,,CCO,,O,,val
US20060084688A1,CC#N.CCN=C=NCCCN(C)C.CN1CCOCC1.Cl.NOC1CCCCO1>>CC#CN1CCC(C(=O)O)CC1.Cl,,CC#N,,,,val
US06239151B1,CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)C1(N)CCCC1)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1.Cc1ccc(S(=O)(=O)O)cc1>>CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)C1(N)CCCC1)[C@H](C/C=C/c1ccccc1)C(=O)NO.Cc1ccc(S(=O)(=O)O)cc1,,CO,,,,val
US20120107269A1,CCI.COc1ccc(C=O)cc1O>>CCOc1cc(C=O)ccc1OC,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130158043A1,CSc1ncc2ccc(=O)[nH]c2n1.ClCc1ncsc1C1CC1>>CSc1ncc2ccc(=O)n(Cc3ncsc3C3CC3)c2n1,,CN(C)C=O,,[H-].[Na+],,val
US20110212103A1,Cc1c(C(=O)O)sc2ncnc(Nc3cccnc3OCCO)c12.N>>Cc1c(C(N)=O)sc2ncnc(Nc3cccnc3OCCO)c12,,C1COCCO1,,,,val
US04728739,CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1=O.CON>>CON=C1CCCCC1(C)COc1ccc(CC2SC(=O)NC2=O)cc1,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20080227724A1,CCCCCCCCCCCCCCCCS(=O)(=O)Cl.N[C@H]1CCCNC(=O)C1>>CCCCCCCCCCCCCCCCS(=O)(=O)N[C@H]1CCCNC(=O)C1,,ClCCl,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20060160864A1,CCCNCC(C)C.O=Cc1cc(Br)ccc1F>>CCCN(CC(C)C)c1ccc(Br)cc1C=O,,CS(C)=O,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US05990133,Nc1cc2c(c(-c3cccnc3)c1)OCC2.O=C(Cl)Oc1ccccc1>>O=C(Nc1cc2c(c(-c3cccnc3)c1)OCC2)Oc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20150031687A1,COC(=O)C1=C(C)NC(c2nccs2)=NC1c1ccc(F)cc1Cl.O=C1CCC(=O)N1Br>>COC(=O)C1=C(CBr)NC(c2nccs2)=NC1c1ccc(F)cc1Cl,,ClC(Cl)(Cl)Cl,,,,val
US20110281854A1,C[C@@H]1CN[C@H](c2ccccc2Cl)CO1.O=C1COc2cnc(Cl)nc2N1>>C[C@H]1CN(c2ncc3c(n2)NC(=O)CO3)[C@@H](c2ccccc2Cl)CO1,,CS(C)=O,,,,val
US04303666,Nc1cc(Cl)ccc1[N+](=O)[O-].[Se]=[SeH-](c1ccccc1)c1ccccc1>>Nc1cc([Se]c2ccccc2)ccc1[N+](=O)[O-],,C1CCOC1,CCO,O,[BH4-].[Na+],val
US20140228361A1,CCN1CCCC2CNCC21.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCCl>>CCN1CCCC2CN(CCCOc3cc4c(Nc5ccc(F)c(Cl)c5)ncnc4cc3OC)CC21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04898871,CN(C)CCCN.O=C1c2ccccc2C(Cl)N1c1ccc2ccc(Cl)nc2n1>>CN(C)CCCNC1c2ccccc2C(=O)N1c1ccc2ccc(Cl)nc2n1,,C1CCOC1,,,,val
US20080227939A1,C[Si](C)(C)C#Cc1ccc(C#Cc2ccc(C#C[Si](C)(C)C)cc2)cc1>>C#Cc1ccc(C#Cc2ccc(C#C)cc2)cc1,,ClCCl,,CO,[K+].[OH-],val
US20150152076A1,CCOC(=O)CC(=O)CC/C=C(\C)CCC=C(C)C.NN>>CC(C)=CCC/C(C)=C/CCc1cc(O)n[nH]1,,CCO,,,,val
US04443462,C=COC(=O)N1CCC(Oc2cccc3c(OC)cccc23)CC1.Cl>>COc1cccc2c(OC3CCNCC3)cccc12.Cl,,CO,,,,val
US20030119890A1,CC(N)C(C)(C)C.N#Cc1ccc(N=C=S)cc1>>CC(NC(=S)Nc1ccc(C#N)cc1)C(C)(C)C,,C1CCOC1,,,,val
US20070093473A1,CC(C)(C)[Si](C)(C)OCc1ccc(Br)cn1.COc1cc2c(cc1S(=O)(=O)F)CCN(C)CC2>>COc1cc2c(cc1S(=O)(=O)c1ccc(CO[Si](C)(C)C(C)(C)C)nc1)CCN(C)CC2,,C1CCOC1,,[Li]CCCC,,val
US20080269293A1,COC(=O)c1cc(Oc2ccccc2[N+](=O)[O-])n(-c2ccccc2)n1>>COC(=O)c1cc(Oc2ccccc2N)n(-c2ccccc2)n1,[Pd],CO,,,,val
US20160081334A1,O=C(O)c1ccc(Br)cn1.Oc1c(F)c(F)c(F)c(F)c1F>>O=C(Oc1c(F)c(F)c(F)c(F)c1F)c1ccc(Br)cn1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20110034512A1,Fc1ccc(I)cc1.O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2[nH]ncc12>>O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)cc1,[Cu]I,CCOC(C)=O,O,CN[C@@H]1CCCC[C@H]1NC,O=C([O-])[O-].[K+].[K+],val
US20100080770A1,C=CCCCCOC(=O)N[C@H](C(=O)O)C(C)(C)C.C=Cc1cc2cc([C@@]3(OC)CN[C@H](C(=O)OC)C3)ccc2cc1N(C)C>>C=CCCCCOC(=O)N[C@H](C(=O)N1C[C@](OC)(c2ccc3cc(N(C)C)c(C=C)cc3c2)C[C@H]1C(=O)OC)C(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04837220,Fc1ccc(C2=NNCC2c2ccc(F)cc2)cc1.O=C=Nc1ccc(OC(F)F)cc1>>O=C(Nc1ccc(OC(F)F)cc1)N1CC(c2ccc(F)cc2)C(c2ccc(F)cc2)=N1,,ClCCl,,,,val
US20140303112A1,C[Mg]Cl.Clc1nc(I)nc2nc[nH]c12>>Cc1nc(Cl)c2[nH]cnc2n1,,CCCCO,,,,val
US20160157491A1,C=Cc1ccc2c(ccc3c2ncn3-c2ccc(OC(F)(F)F)cc2)c1.CI>>C=Cc1ccc2c(ccc3c2nc(C)n3-c2ccc(OC(F)(F)F)cc2)c1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20110195954A1,O=C(CCc1c[nH]c2ccccc12)N1CCCC1>>c1ccc2c(CCCN3CCCC3)c[nH]c2c1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05709867,CC(=O)O.O=[N+]([O-])c1ccc(CO)cc1>>CC(=O)OCc1ccc([N+](=O)[O-])cc1,,O,,CC(=O)OC(C)=O,,val
US20060148858A1,CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCCO.COC(=O)Cc1cn(-c2ccccc2)nc1O>>CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCCOc1nn(-c2ccccc2)cc1CC(=O)O,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US06030926,COCCl.O=C(c1ccccc1)c1c[nH]nc1-c1cccc(Cl)c1>>COCn1cc(C(=O)c2ccccc2)c(-c2cccc(Cl)c2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20130116258A1,CC(=O)OC(C)=O.N#Cc1ncc(N2C(=O)C3(CCC3)N(c3ccc(OCCN4CCNCC4)c(F)c3)C2=S)cc1C(F)(F)F>>CC(=O)N1CCN(CCOc2ccc(N3C(=S)N(c4cnc(C#N)c(C(F)(F)F)c4)C(=O)C34CCC4)cc2F)CC1,,ClCCl,,CCN(CC)CC,,val
US20110237573A1,CC(=O)N1CCN(c2ccc(N)nc2)CC1.Cc1cc(CC(=O)O)cnc1Cl>>CC(=O)N1CCN(c2ccc(NC(=O)Cc3cnc(Cl)c(C)c3)nc2)CC1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04775677,CCCCCCCCCCCNC(=S)NCCCCCCCCCCC.O=C(O)C#CC(=O)O>>CCCCCCCCCCCN=C1SC(=CC(=O)O)C(=O)N1CCCCCCCCCCC,,C1CCOC1,CO,,,val
US20100197654A1,COC(=O)[C@@H]1C[C@@H](F)CN1C(=O)OC(C)(C)C.Nc1cnccn1>>CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)Nc1cnccn1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20070197558A1,CC(C)c1ccc2c(Nc3cc(S(=O)(=O)Nc4ccc(Br)cc4)ccc3Sc3ccc(NC(=O)OC(C)(C)C)cc3)ncnc2n1.O=C(O)C(F)(F)F>>CC(C)c1ccc2c(Nc3cc(S(=O)(=O)Nc4ccc(Br)cc4)ccc3Sc3ccc(N)cc3)ncnc2n1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04897406,COc1ccc(C=CC(C)=O)cc1OC.O=C1CSC(=S)N1>>COc1ccc(C=C(C)C=C2SC(=S)NC2=O)cc1OC,,Cc1ccccc1,,C,O=C[O-].[NH4+],val
US20100048581A1,COC(=O)c1nccc(Sc2cnc(Nc3nccc4sccc34)s2)c1F>>O=C(O)c1nccc(Sc2cnc(Nc3nccc4sccc34)s2)c1F,,O,,Cl,[Na+].[OH-],val
US04729994,COc1ccc(CCI)cc1OC.COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1.I>>COc1ccc([C@@H]2Sc3ccccc3N(CC[N+](C)(C)CCc3ccc(OC)c(OC)c3)C(=O)[C@@H]2OC(C)=O)cc1.[I-],,CCOC(C)=O,,,,val
US20130345199A1,CC(C)(C)OC(=O)Nc1cccc(CN2CCC(C(=O)O)CC2)c1.NC1CCCCC1>>CC(C)(C)OC(=O)Nc1cccc(CN2CCC(C(=O)NC3CCCCC3)CC2)c1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20150336944A1,N#Cc1cc(S(=O)(=O)Nc2cscn2)ccc1Oc1cnc(Cl)cc1-c1cn[nH]c1.OB(O)c1cccc(F)c1>>N#Cc1cc(S(=O)(=O)Nc2cscn2)ccc1Oc1cnc(-c2cccc(F)c2)cc1-c1cn[nH]c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20070099990A1,Cc1c(C)c2c(c(C)c1NC(=O)CC(C)(C)C)C(O)(C1CCCCC1)C(C)(C)O2>>Cc1c(C)c2c(c(C)c1NC(=O)CC(C)(C)C)C(C1CCCCC1)C(C)(C)O2,,CCCCCC,CCOC(C)=O,,,val
US20150133428A1,C=C1CC(C(=O)OCC)C1.CI>>C=C1CC(C)(C(=O)OCC)C1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US05283248,CC(C)(C)OC(=O)N1CCN(c2cc3c(cc2F)n2c(=O)n(OCc4ccccc4)c(=O)cc2n3C2CC2)CC1>>CC(C)(C)OC(=O)N1CCN(c2cc3c(cc2F)n2c(=O)n(O)c(=O)cc2n3C2CC2)CC1,[Pd],CCO,,,,val
US05668291,ClCCl.Nc1ccc(Cl)cc1Cl.O=C(Cl)c1ccccc1SSc1ccccc1C(=O)Cl.c1ccncc1>>O=C(Nc1ccc(Cl)cc1Cl)c1ccccc1SSc1ccccc1C(=O)Nc1ccc(Cl)cc1Cl,,ClCCl,c1ccncc1,,,val
US05591751,Cc1ccccc1C=CC(=O)Cl.NC(=O)c1ccc(N)cc1>>Cc1ccccc1C=CC(=O)Nc1ccc(C(N)=O)cc1,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090221608A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CNc1ccc(Br)cn1>>CNc1ccc(B2OC(C)(C)C(C)(C)O2)cn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,CC(=O)[O-].[K+],,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccc(C(=O)O)cn3)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3ccc(C(=O)O)cn3)c2)=C(C)C1=O,,CO,Cl,O=C([O-])O.[Na+],,val
US04299831,Nc1nccs1.O=C(Cl)c1c(C(F)(F)F)nc2cc(C(F)(F)F)ccc2c1O>>O=C(Nc1nccs1)c1c(C(F)(F)F)nc2cc(C(F)(F)F)ccc2c1O,,CCOC(C)=O,,CCN(CC)CC,,val
US20060148858A1,CCOC(=O)C(C)(C)Br.COCOc1cc(O)ccc1C>>CCOC(=O)C(C)(C)Oc1ccc(C)c(OCOC)c1,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20140275035A1,CCOC(=O)N1CCc2sc3ccn(-c4ccccc4)c3c2CC1>>c1ccc(-n2ccc3sc4c(c32)CCNCC4)cc1,,CCO,O,[K+].[OH-],,val
US20150018422A1,CO.Clc1ncccc1Br>>COc1ncccc1Br,,CN(C)C=O,,O,C[O-].[Na+],val
US04005208,CC(=O)OC1c2ccccc2Oc2ccccc21.CN1CCC(N)CC1>>CN1CCC(NC2c3ccccc3Oc3ccccc32)CC1,,c1ccccc1,,,,val
US20050119256A1,CCCC[Sn](CCCC)(CCCC)c1ccncc1.CCOC(=O)[C@H](Cc1cccc(Oc2cccc(Br)c2)c1)NC(=O)C(F)(F)F>>CCOC(=O)[C@H](Cc1cccc(Oc2cccc(-c3ccncc3)c2)c1)NC(=O)C(F)(F)F,,C1COCCO1,,CCOC(C)=O,,val
US20050009845A1,CC(C)(C)OC(=O)N1[C@@H](C#Cc2cc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3s2)COC1(C)C>>N[C@@H](C#Cc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2s1)CO,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070010670A1,O=C(O)c1ccc(OCc2ccccc2)cc1.c1ccc2c(c1)NCCO2>>O=C(c1ccc(OCc2ccccc2)cc1)N1CCOc2ccccc21,CN(C)c1ccncc1,ClC(Cl)Cl,,CCN=C=NCCCN(C)C,Cl,val
US20100179128A1,CCCCCn1c(=O)n(CCCO)c(=O)c2[nH]c(Cl)nc21.NC1(c2ccccc2)CC1.O=C(n1ccnc1)n1ccnc1>>CCCCCn1c(=O)n(CCCOC(=O)NC2(c3ccccc3)CC2)c(=O)c2[nH]c(Cl)nc21,,C1CCOC1,,,,val
US20120028971A1,COC(=O)CC1(CCCN=[N+]=[N-])CC1.Cl>>COC(=O)CC1(CCCN)CC1.Cl,[Pd],CCO,,,,val
US20070225280A1,CCOC(=O)c1cnn(CC2CC2)c1C(F)(F)F>>O=C(O)c1cnn(CC2CC2)c1C(F)(F)F,,CO,O,[Li+].[OH-],,val
US20140057891A1,CN1CCNCC1.Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(CBr)cc3)nc3c2cnn3C(C)C)c(=O)[nH]1>>Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(CN4CCN(C)CC4)cc3)nc3c2cnn3C(C)C)c(=O)[nH]1,,CN(C)C=O,,CCOC(C)=O,O,val
US20100216746A1,N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CNC(=O)c3[nH]c(CO)nc3Cl)c2F)c1>>N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CNC(=O)c3[nH]c(C=O)nc3Cl)c2F)c1,O=[Mn]=O,C1COCCO1,ClCCl,,,val
US04511392,COc1cc(OC)nc(N)n1.O=C=NS(=O)(=O)c1ccccc1-c1ccno1>>COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ccccc2-c2ccno2)n1,,CC#N,,,,val
US20050154061A1,Cc1cc(C=O)ccc1OC(C)(C)C(=O)OC(C)(C)C>>Cc1cc(C=O)ccc1OC(C)(C)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130018030A1,CCc1cnc(Cl)nc1.COC(=O)c1ccc(-c2ccc3c(c2)CC(C2CCNCC2)O3)cc1>>CCc1cnc(N2CCC(C3Cc4cc(-c5ccc(C(=O)O)cc5)ccc4O3)CC2)nc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20100197725A1,CCCC(CCC)N1CCc2c(C(=O)N[C@@H](Cc3cc(F)cc(F)c3)[C@H](O)CNC3(c4cccc(C(F)(F)F)c4)CC3)cc(C)cc2C1=O.Cl>>CCCC(CCC)N1CCc2c(C(=O)N[C@@H](Cc3cc(F)cc(F)c3)[C@H](O)CNC3(c4cccc(C(F)(F)F)c4)CC3)cc(C)cc2C1=O.Cl,,C1COCCO1,CCOCC,,,val
US20060135483A1,CCOP(=O)(OCC)C(F)(F)c1ccc(CBr)cc1Br.COC(=O)c1ccccc1-c1ccc(-c2cnc(Nc3ccc(Cl)c(Cl)c3)o2)cc1>>CCOP(=O)(OCC)C(F)(F)c1ccc(CN(c2ccc(Cl)c(Cl)c2)c2ncc(-c3ccc(-c4ccccc4C(=O)OC)cc3)o2)cc1Br,,CN(C)C=O,,[H-].[Na+],,val
US20060040918A1,Fc1ccc(CBr)c(F)c1.Oc1ccc2c(c1)CCN(C1CCC1)CC2>>Fc1ccc(COc2ccc3c(c2)CCN(C2CCC2)CC3)c(F)c1,,CCC(C)=O,,[I-].[K+],,val
US20090149524A1,CCc1n[nH]c(CC)c1CC(=O)OC(C)(C)C>>CCc1n[nH]c(CC)c1CC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130237545A1,CC(N)CO.Cc1nnc(-c2ccccc2)c(C(=O)O)c1-c1ccccc1>>CC(CO)NC(=O)c1c(-c2ccccc2)cnnc1-c1ccccc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100004128A1,C#CCOC1CCCCO1.FC(F)(Br)Br>>FC(F)(Br)C#CCOC1CCCCO1,,C1CCOC1,,[Li]CCCC,,val
US04605664,CC1(C2CCCC2)Cc2cc(O)c(Cl)c(Cl)c2C1=O.CCOC(=O)CCCCCBr>>CCOC(=O)CCCCCOc1cc2c(c(Cl)c1Cl)C(=O)C(C)(C1CCCC1)C2,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06235771B1,CCCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CCS3(=O)=O)cc1.CI>>CCCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(C[N+](C)(C)C4CCOCC4)cc2)CCS3(=O)=O)cc1.[I-],,CN(C)C=O,,,,val
US20110263588A1,Cc1cccc(N)n1.O=C(O)c1n[nH]c2c1COc1ccccc1-2>>Cc1cccc(NC(=O)c2n[nH]c3c2COc2ccccc2-3)n1,,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20050065143A1,C1CNCCN1.O=C(NCCC1CCC1)c1ccc(Cl)nn1>>O=C(NCCC1CCC1)c1ccc(N2CCNCC2)nn1,,CC#N,,,,val
US05276038,CCOC(OCC)OCC.NNC(=O)c1ccccc1N>>Nn1cnc2ccccc2c1=O,,CCO,,,,val
US20070032485A1,CCOC(=O)C1CCN(c2cnc(N[C@H]3C[C@@H](CC)N(C(=O)OC(C)(C)C)c4ccc(OC)nc43)nc2Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1>>CC[C@@H]1C[C@H](Nc2ncc(N3CCC(C(=O)O)CC3)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)c2nc(OC)ccc2N1C(=O)OC(C)(C)C,,C1COCCO1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US20050277681A1,CN(C)C=O.Nc1ncc(C(F)(F)F)cc1I>>N#Cc1cc(C(F)(F)F)cnc1N,,CCOC(C)=O,,,,val
US20060079687A1,COC(OC)c1cc(Sc2cccc(NS(=O)(=O)c3ccccc3)c2)ccc1[N+](=O)[O-]>>O=Cc1cc(Sc2cccc(NS(=O)(=O)c3ccccc3)c2)ccc1[N+](=O)[O-],,C1CCOC1,Cl,O,,val
US20150045359A1,CC(C)(C)OC(=O)N1CCOC(c2ccc(C(=O)CC(=O)c3ccc(Cl)cc3)cc2)C1.NN>>CC(C)(C)OC(=O)N1CCOC(c2ccc(-c3cc(-c4ccc(Cl)cc4)[nH]n3)cc2)C1,,CCO,,O,,val
US04228173,CCO.O=C(O)c1cc(=O)c2cc(O)ccc2s1>>CCOC(=O)c1cc(=O)c2cc(O)ccc2s1,O=S(=O)(O)O,,,,,val
US20140349990A1,Cn1cc(NC(c2ccc(Cl)cc2)c2cn(C3CC3)nc2C(=O)O)cc(Cl)c1=O>>Cn1cc(N2C(=O)c3nn(C4CC4)cc3C2c2ccc(Cl)cc2)cc(Cl)c1=O,,CCOC(C)=O,,,,val
US20130338134A1,COc1cc(OC)c(F)c(N2Cc3cnc4c(ccn4S(=O)(=O)c4ccccc4)c3N(C)C2=O)c1F.Cn1cc(C=O)cn1>>COc1cc(OC)c(F)c(N2Cc3cnc4c(cc(C(O)c5cnn(C)c5)n4S(=O)(=O)c4ccccc4)c3N(C)C2=O)c1F,,C1CCOC1,C1CCOC1,CC(C)[N-]C(C)C.[Li+],,val
US20160130237A1,C=CC(=O)Nc1cc(C(=O)N2CCN(C)CC2)ccc1N(C(=O)OC(C)(C)C)c1cc(N(C)C(=O)N(C(=O)C(C)(C)C)c2c(Cl)c(OC)cc(OC)c2Cl)ncn1>>C=CC(=O)Nc1cc(C(=O)N2CCN(C)CC2)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160068559A1,CC(C)(C)c1ccc(N)cc1F.CN(CCCN)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN(CCCNC(=O)Nc1ccc(C(C)(C)C)c(F)c1)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C2OC(C)(C)O[C@@H]21,,ClCCl,,O,,val
US20130190309A1,COC(=O)c1c(CC=O)cccc1[N+](=O)[O-].Nc1cccc(C(F)(F)F)c1>>O=C1c2c(cccc2[N+](=O)[O-])CCN1c1cccc(C(F)(F)F)c1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20130324579A1,COC(Cn1cc(NC(=O)c2ncoc2-c2cccc(C)c2)cn1)OC>>Cc1cccc(-c2ocnc2C(=O)Nc2cnn(CC=O)c2)c1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20110112073A1,N#CCC(=O)c1cccs1.NNc1ccccc1>>Nc1cc(-c2cccs2)nn1-c1ccccc1,,CO,,,,val
US20030069257A1,CCOC(=O)Cc1ccnn1-c1nccs1.CI>>CCOC(=O)C(C)c1ccnn1-c1nccs1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030018197A1,Cc1nn(-c2ccccc2)c(Sc2cc(Cl)cc(Cl)c2)c1C(=O)c1ccccc1>>Cc1nn(-c2ccccc2)c(Sc2cc(Cl)cc(Cl)c2)c1C(O)c1ccccc1,,CO,O,[BH4-].[Na+],,val
US20080108620A1,CNOC.O=C(Cl)c1cc(Cl)cc(Cl)c1>>CON(C)C(=O)c1cc(Cl)cc(Cl)c1,,ClCCl,,Cl,c1ccncc1,val
US04321269,CC(=O)C(=O)N1CCCCC1.O=S(=O)(Cl)Cl>>O=C(CCl)C(=O)N1CCCCC1,,ClC(Cl)Cl,,,,val
US20050026914A1,CN1CCCC(O)C1.CO.O=[N+]([O-])c1c(O)ccc(F)c1F>>CN1CCCC(COc2ccc([N+](=O)[O-])cc2F)C1,,C1CCOC1,CO,CC(=O)O,[H-].[Na+],val
US20140088078A1,CC(C)(C)OC(=O)N[C@H]1CCNC1.CCI>>CCN1CC[C@H](NC(=O)OC(C)(C)C)C1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090221639A1,CCC(OC1CCN(C(=O)OC(C)(C)C)CC1)c1nc(-c2ccc(SC)c(F)c2)no1.O=C(OO)c1cccc(Cl)c1>>CCC(OC1CCN(C(=O)OC(C)(C)C)CC1)c1nc(-c2ccc(S(C)=O)c(F)c2)no1,,ClCCl,,,,val
US20120129851A1,C1COCCN1.Clc1nc(Cl)c2ncc(Br)cc2n1>>Clc1nc(N2CCOCC2)c2ncc(Br)cc2n1,,ClCCl,,,,val
US04689339,C1CCOC1.CC(=O)[C@H]1Cc2ccccc2[C@H]1C>>CC(=O)C1=C(C)c2cc(C)ccc2C1,,C1CCOC1,,CCOCC,,val
US04512924,NC1CN2CCCC(C(=O)O)N2C1=O.O=C(O)C(=O)CCc1ccccc1>>O=C(O)C(CCc1ccccc1)NC1CN2CCCC(C(=O)O)N2C1=O,,O,,[Na+].[OH-],,val
US04665174,CCCCCC1C(=O)C=CC1(C)O.CCN>>CCCCCC1=C(C)C(NCC)CC1=O,,C1CCOC1,,,,val
US20030069231A1,CC(C)(C)OC(=O)N1CCNCC1.CN1CCNCC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN1CCN(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140275007A1,CC(C)(C)OC(=O)N[C@H](C(=O)O)C(C)(C)O.NOCc1ccccc1>>CC(C)(C)OC(=O)N[C@H](C(=O)NOCc1ccccc1)C(C)(C)O,,C1CCOC1,CCCCCC,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US04278793,CCOC(=O)C(=O)C(=O)CBr.NC(N)=S>>CCOC(=O)C(=O)c1csc(N)n1,,CCO,O,C,,val
US06489487B1,CC(=NOCc1ccccc1)c1cccc(CN=C=O)c1.CN(C)N>>CC(=NOCc1ccccc1)c1cccc(CNC(=O)NN(C)C)c1,,Cc1ccccc1,,CCOC(C)=O,,val
US04083721,CCC(C)(C)c1ccc(OCCCNC(=O)c2cc(N)c3ccccc3c2O)c(C(C)(C)CC)c1.O=C(Cl)C(Cl)(Cl)Cl>>CCC(C)(C)c1ccc(OCCCNC(=O)c2cc(NC(=O)C(Cl)(Cl)Cl)c3ccccc3c2O)c(C(C)(C)CC)c1,,O,,CC#N,CCN(CC)CC,val
US20010041710A1,C[Si](C)(C)CCONC(=O)[C@H]1CN(Cc2ccc(Oc3ccc(F)cc3)cc2)C(=O)N1>>O=C(NO)[C@H]1CN(Cc2ccc(Oc3ccc(F)cc3)cc2)C(=O)N1,,ClCCl,,CCOCC,FB(F)F,val
US20090197862A1,COC(=O)C(C)(OC)OC.NCc1ccccc1>>COC(C)(OC)C(=O)NCc1ccccc1,,CCCCCC,,,,val
US20080242695A1,CCC(=O)CC.Nc1cc(Br)cnc1N>>CCC(CC)Nc1cc(Br)cnc1N,,CC(Cl)Cl,,CC(=O)O,,val
US20140316089A1,CC(C)c1cccc(C(C)C)c1NC(C)(C)c1cccc(Br)n1.Cc1cc(C)c(NCc2ccc3ccccc3c2B2OC(C)(C)C(C)(C)O2)c(C)c1>>Cc1cc(C)c(NCc2ccc3ccccc3c2-c2cccc(C(C)(C)Nc3c(C(C)C)cccc3C(C)C)n2)c(C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],val
US20090130165A1,Cn1c(=O)sc2ccc(Cl)cc21.O=C(Br)CBr>>Cn1c(=O)sc2cc(C(=O)CBr)c(Cl)cc21,,CN(C)C=O,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130078351A1,CCOC(=O)CCC(C)C.NCCO>>CC(C)CCC(=O)NCCO,,CCOC(C)=O,,CCO,,val
US05684034,CCOC(=O)CCCOc1cccc2c1c(CC(N)=O)c(C)n2Cc1ccccc1>>Cc1c(CC(N)=O)c2c(OCCCC(=O)O)cccc2n1Cc1ccccc1,,CCO,O,[Na+].[OH-],,val
US20110183939A1,CON(C)C(=O)C1(C)COC(C)(C)OC1.C[Mg]Br>>CC(=O)C1(C)COC(C)(C)OC1,,C1CCOC1,,[Cl-].[NH4+],,val
US20070265258A1,COc1cc2ncnc(N3CCN(C(=O)OC(C)(C)C)C(c4ccccc4)C3)c2cc1OC.O=C(O)C(F)(F)F>>COc1cc2ncnc(N3CCNC(c4ccccc4)C3)c2cc1OC.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05536725,CSc1nc(N)c2c(n1)CCC(c1ccccc1Cl)C2.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc(N)c2c(n1)CCC(c1ccccc1Cl)C2,,ClC(Cl)Cl,,,,val
US20120184542A1,COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CNC(=O)OC(C)(C)C)C4CCCC4)ccc3Cl)c(=O)[nH]c2n1>>COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CN)C4CCCC4)ccc3Cl)c(=O)[nH]c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04251528,CI.COc1ccc2c(C(=O)O)n[nH]c(=O)c2c1>>COC(=O)c1n[nH]c(=O)c2cc(OC)ccc12,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20160122344A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2C(C)(C)COC.CCOCCBr>>CCOCCOc1cc2c(cc1OC)-c1cc(=O)c(C(=O)OCC)cn1C(C(C)(C)COC)C2,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080090801A1,Cc1nc(N)nc2c1ccc(=O)n2[C@@H]1CC[C@H](OCCO)CC1.O=C1CCC(=O)N1Br>>Cc1nc(N)nc2c1cc(Br)c(=O)n2[C@@H]1CC[C@H](OCCO)CC1,,CN(C)C=O,,,,val
US20070032485A1,CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(COCCC(=O)OC(C)(C)C)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC>>CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(COCCC(=O)O)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC,,C1COCCO1,Cl,,,val
US20090264434A1,COC(=O)C(Br)CC1CCCC1.O=c1cc(I)cn[nH]1>>COC(=O)C(CC1CCCC1)n1ncc(I)cc1=O,,C1CCOC1,,[H-].[Na+],,val
US20020147343A1,Cl.NCCSc1cc(-c2ccc[nH]2)c2c3c(ccc(F)c13)NC2=O>>Cl.NCCSc1cc(-c2ccc[nH]2)c2c3c(ccc(F)c13)NC2=O,,CN(C)C=O,CO,,,val
US20110124679A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1c(C)c(OCc2ccccc2)c(CCN)c(C)c1OCc1ccccc1>>CNCCc1c(C)c(OCc2ccccc2)c(C)c(C)c1OCc1ccccc1,,C1COCCO1,CCOC(C)=O,[Na+].[OH-],,val
US05359055,COC(=O)O[C@@H]1C=C2C[C@@H](OC(C)=O)[C@@H]3O[C@@H]3[C@]2(C)[C@H]2CC[C@]3(C)[C@@H](C(C)C4OCC(C)(C)CO4)CC[C@H]3[C@H]12>>CC(=O)O[C@@H]1CC2=CC=C3[C@@H]4CC[C@H](C(C)C5OCC(C)(C)CO5)[C@@]4(C)CC[C@@H]3[C@@]2(C)[C@H]2O[C@@H]12,,C1COCCO1,,CCCCP(CCCC)CCCC,,val
US20150291632A1,Fc1ccc(Br)c(F)c1.O=C(c1cncnc1)c1ccc(-c2ccc(OC(F)(F)F)cc2)cn1>>OC(c1cncnc1)(c1ccc(-c2ccc(OC(F)(F)F)cc2)cn1)c1ccc(F)cc1F,,CCCCCC,CCOCC,[Li]CCCC,,val
US20060122394A1,CC1CCCN1c1nc(Cl)cc(-c2ccc(F)cc2)n1.Cc1cc(Br)cnc1N1CCN[C@H](C)C1>>Cc1cc(Br)cnc1N1CCN(c2cc(-c3ccc(F)cc3)nc(N3CCCC3C)n2)[C@H](C)C1,,CCO,,O=C([O-])O.[Na+],,val
US20100216798A1,Cc1ccc(OC2CCCCO2)cc1[N+](=O)[O-]>>Cc1ccc(OC2CCCCO2)cc1N,[Pd],CO,,,,val
US20120142714A1,COC(=O)c1cc(OC[C@H](C)NC(=O)OC(C)(C)C)no1>>C[C@@H](COc1cc(C(=O)O)on1)NC(=O)OC(C)(C)C,,C1CCOC1,CO,[Na+].[OH-],,val
US20110065930A1,Cl.O=C(O)[C@@H]1C[C@H]2CCCC[C@@H]2N1.OCc1ccccc1>>Cl.O=C(OCc1ccccc1)[C@@H]1C[C@H]2CCCC[C@@H]2N1,,ClCCl,,O=S(Cl)Cl,,val
US20150133428A1,CC(C)(C)OC(=O)NC(CO)C1CC1.CCOC(=O)c1[nH]nc(I)c1C(=O)OCC>>CCOC(=O)c1c(I)nn(CC(NC(=O)OC(C)(C)C)C2CC2)c1C(=O)OCC,,C1CCOC1,CCOC(C)=O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05134111,CC(=O)OC(C)=O.CCc1cccc2c(/C=C(\C)C(=O)O)cc(OC)c(O)c12>>CCc1cccc2c(/C=C(\C)C(=O)O)cc(OC)c(OC(C)=O)c12,,c1ccncc1,,O,,val
US06150373,O=C1c2ccccc2C(=O)N1CCCc1cccc([N+](=O)[O-])c1>>Nc1cccc(CCCN2C(=O)c3ccccc3C2=O)c1,[Pd],CCO,,[H][H],,val
US20100121048A1,C[Si](C)(C)N=[N+]=[N-].Cc1cc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2Cc2ccccc2)c(-c2ccccc2)n1-c1cccc(C#N)c1>>Cc1cc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2Cc2ccccc2)c(-c2ccccc2)n1-c1cccc(-c2nnn[nH]2)c1,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US06582351B1,N[C@@H]1CC[C@@H](NC=O)CC1.O=[N+]([O-])c1cc(C(F)(F)F)ccc1F>>O=CN[C@@H]1CC[C@@H](Nc2ccc(C(F)(F)F)cc2[N+](=O)[O-])CC1,,c1ccncc1,,O,,val
US20130150364A1,CC(C)(C)OC(=O)NCc1ccc(O)cc1.CS(=O)(=O)c1nc(Cl)cc(Cl)n1>>CC(C)(C)OC(=O)NCc1ccc(Oc2nc(Cl)cc(Cl)n2)cc1,,COCCOC,,[H-].[Na+],[Cl-].[NH4+],val
US20100184741A1,CC1(C)CCN(S(=O)(=O)c2cc(Br)c(Cl)cc2F)c2ccccc21.COC(=O)CC(=O)OC>>COC(=O)C(C(=O)OC)c1cc(Cl)c(Br)cc1S(=O)(=O)N1CCC(C)(C)c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20130109679A1,CCOC(=O)c1ccc2cc(C(=O)OCC)n(CC(F)(F)CN=[N+]=[N-])c2c1>>CCOC(=O)c1ccc2cc(C(=O)OCC)n(CC(F)(F)CN)c2c1,[Pd],CO,ClCCl,,,val
US20120184557A1,CC[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)n2ncc(C(C)C)c2n1.O=C(O)/C=C/C(=O)O>>CC[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)n2ncc(C(C)C)c2n1.O=C(O)/C=C/C(=O)O,,CCO,CCOCC,,,val
US05506190,CC(C)(N)c1ccc(F)cc1.O=C1C2=CC(CCC2)C(=O)N1c1cc(OC2CCCC2)c(Cl)cc1F>>CC(C)(NC(=O)C1=C(C(=O)Nc2cc(OC3CCCC3)c(Cl)cc2F)CCCC1)c1ccc(F)cc1,,c1ccccc1,,CN1CCOCC1,,val
US20150166484A1,CC(=O)c1ccc(Br)cc1.COC(=O)CCC(C)C>>CC(C)CCC(=O)CC(=O)c1ccc(Br)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20120316195A1,CC1(C)OB(c2ccc3c(c2)COC3=O)OC1(C)C.O=Cc1c(F)cncc1Br>>O=Cc1c(F)cncc1-c1ccc2c(c1)COC2=O,,CCOC(C)=O,CN(C)C=O,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US04521535,COC(=O)CC(=O)C=Cc1ccc(Cl)cc1.COC(OC)N(C)C>>COC(=O)C(=CN(C)C)C(=O)C=Cc1ccc(Cl)cc1,,c1ccccc1,,,,val
US04820834,CN1C(=O)C(N)N=C(c2ccccc2)c2ccccc21.O=C=Nc1cccc2ccccc12>>CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)N=C(c2ccccc2)c2ccccc21,,C1CCOC1,,,,val
US20130324576A1,CC1CC(Oc2ccc(Cl)cc2)CCN1C(=O)OC(C)(C)C.Cl>>CC1CC(Oc2ccc(Cl)cc2)CCN1.Cl,,C1COCCO1,,,,val
US20100197683A1,C=CCOC1CCC(=O)CC1.Nc1nc[nH]n1>>C=CCOC1CCC(Nc2nnc[nH]2)CC1,,CC(=O)O,,O,[BH3-]C#N.[Na+],val
US20110144136A1,O=C(OCc1ccccc1)ON1C(=O)CCC1=O.OCCCC1CCCNC1>>O=C(OCc1ccccc1)N1CCCC(CCCO)C1,,ClCCl,,CCN(CC)CC,,val
US20040186091A1,CN.O=c1[nH]c2ccc(Cl)cc2c(=O)o1>>CNC(=O)c1cc(Cl)ccc1N,,C1CCOC1,,CCOC(C)=O,O,val
US20090318429A1,CCOC(=O)c1ncn(-c2cc(Cl)c(OCc3ccc(OC)cc3)c(Cl)c2)n1>>COc1ccc(COc2c(Cl)cc(-n3cnc(C(=O)O)n3)cc2Cl)cc1,,CCO,O,Cl,[K+].[OH-],val
US20030109527A1,CC(C)(C)OC(=O)NCCCNS(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2ccccc2Br)c1O.Cl>>Cl.NCCCNS(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2ccccc2Br)c1O,,C1COCCO1,Cl,,,val
US05136868,COc1cc(NC(C)=O)c(Cl)cc1Cl>>COc1cc(N)c(Cl)cc1Cl,,CCO,O,[Na+].[OH-],,val
US20110028493A1,CCOC(=O)c1cnn(Cc2ccc(-c3cccc(C(F)(F)F)c3)s2)c1>>O=C(O)c1cnn(Cc2ccc(-c3cccc(C(F)(F)F)c3)s2)c1,,C1CCOC1,CCO,O,[Na+].[OH-],val
US20090239854A1,C=C(C(=O)O)c1ccc(C(F)(F)F)nc1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>Cc1ccc2c(c1)c1c(n2CC(C(=O)O)c2ccc(C(F)(F)F)nc2)CCN(C)C1,,CN1CCCC1=O,,[K+].[OH-],,val
US20110136763A1,CC(C)Br.CCOC(=O)CC1OB(O)c2cc(OC3CCCCO3)cc(O)c21>>CCOC(=O)CC1OB(O)c2cc(OC3CCCCO3)cc(OC(C)C)c21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04243609,CCCCCCCCCCCCCCCCNc1ccc(C(=O)Cl)cc1F.CS(N)(=O)=O>>CCCCCCCCCCCCCCCCNc1ccc(C(=O)NS(C)(=O)=O)cc1F,,c1ccncc1,,Cl,,val
US04358448,CON=C(C(=O)O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1.Cc1cc(C)c(S(=O)(=O)ON)c(C)c1>>CON=C(C(=O)O)c1csc(=NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1N,,ClCCl,,,,val
US05238837,COC(=O)CCCCCCCCCCCCCCCCCOS(=O)(=O)c1ccc(C)cc1.O=C1NC(=O)c2ccccc21>>COC(=O)CCCCCCCCCCCCCCCCCN1C(=O)c2ccccc2C1=O,,CN(C)C=O,,[K],,val
US20100063091A1,COC=Cc1cc(OCc2ccccc2)cc(C(=O)OC)c1>>COCCc1cc(O)cc(C(=O)OC)c1,[Pd],CCO,,,,val
US04824958,BrBr.CC(C)Sc1cc([Si](C)(C)C)oc1C(=O)Nc1nnn[nH]1>>CC(C)Sc1cc(Br)oc1C(=O)Nc1nnn[nH]1,,CC(=O)O,ClC(Cl)Cl,O,,val
US20150023913A1,CC(=O)OC(C)=O.CCOC(=O)C1(CN)CCCCO1>>CCOC(=O)C1(CNC(C)=O)CCCCO1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090318521A1,Cc1ccc(-c2ccccc2C=O)cc1.O=C(OOC(=O)c1ccccc1)c1ccccc1>>Cc1ccc(-c2ccccc2C(=O)O)cc1,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClCCl,,O=C1CCC(=O)N1Br,,val
US20060269926A1,CCCCCCNCCCCCC.Cc1nc2ccc(S(=O)(=O)Cl)cc2s1>>CCCCCCN(CCCCCC)S(=O)(=O)c1ccc2nc(C)sc2c1,,CCOC(C)=O,ClC(Cl)Cl,CCCCCC,,val
US20050245563A1,COCCC(=O)c1c(O)c2cc(Cl)ccc2[nH]c1=O.NN>>COCCc1[nH]nc2c1c(=O)[nH]c1ccc(Cl)cc12,,CCOCC,CN(C)C=O,O,,val
US20150119380A1,CC(C)(C)OC(=O)N1CCN(c2ccc(C=O)c(O)c2)CC1.CCOC(=O)CC(=O)CC>>CCC(=O)c1cc2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2oc1=O,,CC#N,,C1CCNCC1,CC(=O)O,val
US20150232476A1,CCN1CCc2c(sc(NC(=O)OC(C)(C)C)c2-c2nc(C)no2)C1>>CCN1CCc2c(sc(N)c2-c2nc(C)no2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110251190A1,O=P(Cl)(Cl)Cl.O=c1c2cc(Br)ccc2oc2c([N+](=O)[O-])cc[n+]([O-])c12>>O=c1c2cc(Br)ccc2oc2c([N+](=O)[O-])cc(Cl)nc12,,CN(C)C=O,Cc1ccccc1,,,val
US20110009395A1,COc1cccc(-c2cccc(C34CC(O[Si](C)(C)C(C)(C)C)CC3CSC(NC(=O)c3ccccc3)=N4)c2)c1>>COc1cccc(-c2cccc(C34CC(O[Si](C)(C)C(C)(C)C)CC3CSC(N)=N4)c2)c1,,CCO,CCOC(C)=O,NN,,val
US05234821,C=[N+]=[N-].COCN1C(C)=C(C(=O)O)[C@H](c2cccc([N+](=O)[O-])c2)C(C(=O)OCOC(=O)C(C)(C)C)=C1C>>COCN1C(C)=C(C(=O)OC)[C@H](c2cccc([N+](=O)[O-])c2)C(C(=O)OCOC(=O)C(C)(C)C)=C1C,,CCOCC,ClCCl,CC(=O)O,,val
US20100222319A1,Nc1ccccc1.O=C(O)c1ccc(Cl)nc1Cl>>O=C(O)c1ccc(Cl)nc1Nc1ccccc1,,C1CCOC1,O,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US05840991,COc1cc(CSc2ccc(O)cc2)cc(OC)c1OC>>COc1cc(CSc2ccc(O)cc2)cc(OC)c1O,,ClCCl,,O,,val
US20110230462A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC(C(=O)O)C(F)(F)F>>CC(C)(C)OC(=O)NC(C(=O)O)C(F)(F)F,,CC#N,ClCCl,CCN(CC)CC,,val
US20020055497A1,CC(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2CC2CO2)C1.Clc1ccc2oc(C3CCNCC3)nc2c1>>CC(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2CC(O)CN2CCC(c3nc4cc(Cl)ccc4o3)CC2)C1,,CCO,,,,val
US04684648,CCOC(=O)C(=CN(C)C)C(=O)c1cc(F)c(F)cc1Br.COc1ccc(N)c(F)c1>>CCOC(=O)c1cn(-c2ccc(OC)cc2F)c2cc(F)c(F)cc2c1=O,,c1ccccc1,,,,val
US04500629,CC(=O)C=Cc1ccccc1.O=Cc1ccc(O)cc1>>O=C(C=Cc1ccccc1)C=Cc1ccc(O)cc1,,CCO,O,Cl,[Na+].[OH-],val
US05380718,COC(=O)Cc1ccc(F)cc1.Fc1cccc(CBr)c1>>O=C(O)C(Cc1cccc(F)c1)c1ccc(F)cc1,,C1CCOC1,,[H-].[Na+],,val
US20090247746A1,COCn1c(-c2ncc(CO)s2)cc2cccc(N(C)S(=O)(=O)c3cccs3)c21>>CN(c1cccc2cc(-c3ncc(CO)s3)[nH]c12)S(=O)(=O)c1cccs1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20070032499A1,CCOC(=O)CC#N.N#Cc1nc2c(nc1C#N)-c1ccccc1C2=O>>CCOC(O)=C(C#N)c1nc2c(nc1C#N)C(=O)c1ccccc1-2,,CN(C)C=O,,CO,[H-].[Na+],val
US20100144723A1,BrCC1CCC1.O=C1CN(Cc2ccc(Br)cc2)C(=O)N1>>O=C1CN(Cc2ccc(Br)cc2)C(=O)N1CC1CCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160083387A1,C=C1CC[C@H]2[C@H](C(=O)O)[C@@H]([C@@]3(C)CC[C@H](OC(C)=O)C[C@H]3COC(C)=O)CC[C@]12C>>C=C1CC[C@H]2[C@H](C(=O)O)[C@@H]([C@@]3(C)CC[C@H](O)C[C@H]3CO)CC[C@]12C,,CO,,[Na+].[OH-],,val
US20060100201A1,CN1CCN(c2ccc(N3CCCCC3)c([N+](=O)[O-])c2)CC1.N#Cc1ccc(C(=O)O)o1>>CN1CCN(c2ccc(N3CCCCC3)c(NC(=O)c3ccc(C#N)o3)c2)CC1,[Pd],,,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20070299113A1,O=C(O)CBr.S=c1[nH]cc(C23CC4CC(CC(C4)C2)C3)[nH]1>>O=C(O)CSc1nc(C23CC4CC(CC(C4)C2)C3)c[nH]1,,CCO,,,,val
US04916148,CC1(C)C(=O)Oc2ccc3cc(C#N)c(Cn4cncn4)cc3c21>>CC1(C)c2c(ccc3cc(C#N)c(Cn4cncn4)cc23)OC1O,,O,,CCO,[BH4-].[Na+],val
US20130217668A1,CC(C)(O)C1CCN(CCOc2cc3c(cn2)[nH]/c(=N\C(=O)c2cccc(F)c2)n3[C@@H]2CC[C@H](C(=O)O)CC2)CC1.FC1(F)CNC1>>CC(C)(O)C1CCN(CCOc2cc3c(cn2)[nH]/c(=N\C(=O)c2cccc(F)c2)n3[C@@H]2CC[C@H](C(=O)N3CC(F)(F)C3)CC2)CC1,,CN(C)C=O,ClCCl,Cl,O=C(n1ccnc1)n1ccnc1,val
US05750531,CNc1ccccc1.Cc1nc(N2CCc3ccccc3[C@@H]2C)nc(Cl)c1C>>Cc1nc(N2CCc3ccccc3[C@@H]2C)nc(N(C)c2ccccc2)c1C.Cl,,CN(C)C=O,,,,val
US20100298306A1,COC(=O)C(=O)OC.O=C1C=C(c2ccc(F)cc2)CCC1>>COC(=O)C(=O)C1CCC(c2ccc(F)cc2)=CC1=O,,CCOCC,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20110281835A1,CC(C)(C)OC(=O)N1CC(=O)C1.Fc1cccc(Br)c1F>>CC(C)(C)OC(=O)N1CC(O)(c2cccc(F)c2F)C1,,CCOCC,,[Li]CCCC,[Cl-].[NH4+],val
US20040063954A1,CC(=O)OC(C)=O.COC1(OC)CCN(c2ccc(N3C[C@H](CN)OC3=O)cc2)CC1F>>COC1(OC)CCN(c2ccc(N3C[C@H](CCC(N)=O)OC3=O)cc2)CC1F,,CCOC(C)=O,,c1ccncc1,,val
US06143763,CCC(CN(C(=O)NCCCOc1ccc2nc(Cl)ccc2c1)C1CCCCC1)OC(C)=O.CI>>CCC(CN(C(=O)N(C)CCCOc1ccc2nc(Cl)ccc2c1)C1CCCCC1)OC(C)=O,,CN(C)C=O,,O,[H-].[Na+],val
US04220658,CN=C(NC(N)=O)Nc1c(Cl)cccc1Cl>>CN=C(NC(N)=O)Nc1c(Cl)cccc1Cl,,[Na+],[OH-],Cl,,val
US20050026901A1,CC(c1ccccc1)n1ccnc1.O=C1CCN(Cc2ccccc2)CC1>>OC1(c2nccn2CCc2ccccc2)CCN(Cc2ccccc2)CC1,,C1CCOC1,O,CCCCCC,[Li]CCCC,val
US06423840B1,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)CC(NC(=O)C1CCCN2C(=O)CCC(NC(=O)c3ccccc3)C(=O)N12)C(O)COCc1c(Cl)cccc1Cl>>CC(C)(C)OC(=O)CC(NC(=O)C1CCCN2C(=O)CCC(NC(=O)c3ccccc3)C(=O)N12)C(=O)COC(=O)c1c(Cl)cccc1Cl,,CCOC(C)=O,ClCCl,,,val
US04374067,Cc1ccccc1NC(=O)C(C)(C)C.O=Cc1ccccc1>>CC(C)(C)C(=O)Nc1ccccc1CC(O)c1ccccc1,,C1CCOC1,CCOCC,CCCCCC,[Li]CCCC,val
US20040106616A1,O=[N+]([O-])c1cc(-c2ncccc2C(F)(F)F)cnc1Cl>>Nc1cc(-c2ncccc2C(F)(F)F)cnc1Cl,[Fe],CCO,O,[Ca+2].[Cl-].[Cl-],,val
US20090143383A1,CCCN(CCO)C(=O)OC(C)(C)C.COc1nc(Br)ccc1[N+](=O)[O-]>>CCCN(CCOc1ccc([N+](=O)[O-])c(OC)n1)C(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090221654A1,O=C(/C=C/[C@H]1[C@H](OC(=O)c2ccccc2)C[C@@H]2OC(=O)C[C@@H]21)COc1ccccc1>>O=C(CC[C@H]1[C@H](OC(=O)c2ccccc2)C[C@@H]2OC(=O)C[C@@H]21)COc1ccccc1,[Pd],CCOC(C)=O,,,,val
US20120046304A1,CC(=O)O[C@H]1c2nc(C3CCOCC3)c3c(c2[C@@H](O[Si](C)(C)C(C)(C)C)CC1(C)C)C1(CCCC1)O[C@@H]3c1ccc(C(C)(C)C)cc1>>CC(C)(C)c1ccc([C@H]2OC3(CCCC3)c3c4c(nc(C5CCOCC5)c32)[C@H](O)C(C)(C)C[C@@H]4O)cc1,,CCOCC,CO,O=C([O-])[O-].[K+].[K+],,val
US20100087495A1,C=CCOc1c(C)cc(C(=N)NO)cc1C.Cc1cc(C(=O)O)cc(C)c1OC(C)C>>C=CCOc1c(C)cc(-c2noc(-c3cc(C)c(OC(C)C)c(C)c3)n2)cc1C,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US03931235,Cc1cc(O)cc(=O)o1.Cc1ccc(S(=O)O)cc1.Cl>>Cc1cc(O)c(Sc2ccc(Cl)cc2)c(=O)o1,,CCO,,[Na],,val
US20130109688A1,c1ccc(Cn2ccc3c(-c4cc5ncccc5c(N5CCOCC5)n4)cccc32)cc1>>c1cc(-c2cc3ncccc3c(N3CCOCC3)n2)c2cc[nH]c2c1,,COc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05047411,CCN=C=O.Nc1cc(CCc2ccccn2)ccc1O>>CCNC(=O)Nc1cc(CCc2ccccn2)ccc1O,,CCO,,,,val
US04402974,CCO.O=C(O)c1ccc(O)c(O)c1>>CCOC(=O)c1ccc(O)c(O)c1,,O,,O=S(=O)(O)O,,val
US06399629B1,O=[N+]([O-])c1ccccc1NCCc1ccccc1>>Nc1ccccc1NCCc1ccccc1,[Pd],CO,,,,val
US20080153828A1,CCOC(OCC)c1cccn2c(-c3c(C)nc4c(C(CC)CC)cc(C)nn34)c(C)nc12>>CCC(CC)c1cc(C)nn2c(-c3c(C)nc4c(C=O)cccn34)c(C)nc12,,CC(C)=O,,Cl,,val
US20070287737A1,COC(=O)c1c(Nc2ccc(I)cc2F)cncc1-c1ccccc1F>>O=C(O)c1c(Nc2ccc(I)cc2F)cncc1-c1ccccc1F,,CO,,[Na+].[OH-],,val
US20110065702A1,O=C1Cc2cc(C(=O)Nc3ccccc3)ccc2N1.O=Cc1ccc2cn[nH]c2c1>>O=C1Nc2ccc(C(=O)Nc3ccccc3)cc2/C1=C\c1ccc2cn[nH]c2c1,,CO,,C1CCNCC1,,val
US07153874B2,COP(=O)(OC)C(=[N+]=[N-])C(C)=O.Cc1nc(C=O)cn1-c1ccc(F)cc1>>C#Cc1cn(-c2ccc(F)cc2)c(C)n1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US04962115,Br.O=c1[nH]c2cc(Cl)ccc2n1CCCO>>O=c1[nH]c2cc(Cl)ccc2n1CCCBr,,O,,,,val
US20060074087A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1nc(C(F)(F)F)cc(CO[Si](C)(C)C(C)(C)C)c1CCN>>COc1nc(C(F)(F)F)cc(CO[Si](C)(C)C(C)(C)C)c1CCNC(=O)OC(C)(C)C,,ClCCl,,,,val
US20110263629A1,CC(C)(C)OC(=O)N1C[C@H]2CNC[C@@H]1C2.CS(=O)(=O)Cl>>CS(=O)(=O)N1C[C@@H]2C[C@@H](CN2)C1,,ClCCl,,CCN(CC)CC,,val
US20150018343A1,COC(=O)c1cc(F)ccc1OCCc1cccnn1>>O=C(O)c1cc(F)ccc1OCCc1cccnn1,,O,,Cl,[Na+].[OH-],val
US20140073606A1,Nc1ncnc2c1ncn2[C@H]1[C@@H](F)[C@H](OC(=O)c2ccccc2)[C@@H](COC(=O)c2ccccc2)C1(O)CO>>C=C1[C@H](COC(=O)c2ccccc2)[C@@H](OC(=O)c2ccccc2)[C@H](F)[C@@H]1n1cnc2c(N)ncnc21,,CC#N,,O=C([O-])O.[Na+],,val
US20080004271A1,NC(=O)c1sc2ncnc(-c3cccc(N)c3)c2c1N.Nc1ccc(C(F)(F)F)cc1N.S=C(n1ccnc1)n1ccnc1>>NC(=O)c1sc2ncnc(-c3cccc(Nc4nc5cc(C(F)(F)F)ccc5[nH]4)c3)c2c1N,,CN(C)C=O,,,,val
US20150361082A1,CN1c2cc(Cl)nc(=O)n2CC1(C)C.OCc1ccc(Oc2ccnc(C(F)(F)F)c2)c(F)c1>>CN1c2cc(OCc3ccc(Oc4ccnc(C(F)(F)F)c4)c(F)c3)nc(=O)n2CC1(C)C,,C1CCOC1,,[H-].[Na+],,val
US20140179667A1,CCN(CC)C(=O)Cl.O=C1NCCc2ccc(O)c(Cl)c21>>CCN(CC)C(=O)Oc1ccc2c(c1Cl)C(=O)NCC2,,c1ccncc1,,O,,val
US20040157149A1,O=C(O)c1ccc(S(=O)(=O)CCCl)cc1>>C=CS(=O)(=O)c1ccc(C(=O)O)cc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20080132496A1,CC(NC(=O)c1ccc(C(=O)N2CCCC2CNC(=O)OC(C)(C)C)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1>>CC(NC(=O)c1ccc(C(=O)N2CCCC2CN)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,,val
US20160145247A1,CC(C)(C)OC(=O)Cc1ccccc1N.CC(C)(C)OC(=O)NCc1cc(F)cc(-c2cccc(C(=O)O)n2)c1>>CC(C)(C)OC(=O)Cc1ccccc1NC(=O)c1cccc(-c2cc(F)cc(CNC(=O)OC(C)(C)C)c2)n1,,ClCCl,,CCOC(C)=O,,val
US20070054935A1,CCOC(=O)c1cnc2cc(C(F)(F)F)ccc2c1OS(=O)(=O)C(F)(F)F.OB(O)c1ccc(-c2ccccc2)cc1>>CCOC(=O)c1cnc2cc(C(F)(F)F)ccc2c1-c1ccc(-c2ccccc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20120040954A1,C1CCNCC1.COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(OCCBr)c(C)c3)nc2c1>>COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(OCCN4CCCCC4)c(C)c3)nc2c1,,CN(C)C=O,,O,,val
US05543416,COC(=O)c1onc(C(C)C)c1C(=O)OC>>COC(=O)c1c(C(C)C)noc1C(=O)O,,CO,O,[Na+].[OH-],,val
US20150291562A1,NCCOCCOCCOCCOc1ccc([N+](=O)[O-])cc1.O=C1CCC(N2C(=O)c3cccc(F)c3C2=O)C(=O)N1>>O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCOCCOc4ccc([N+](=O)[O-])cc4)c3C2=O)C(=O)N1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20140004243A1,COc1ccccc1CCN>>NCCc1ccccc1O,,Br,,,,val
US20070010556A1,CCCC[Sn](CCCC)(CCCC)c1ccncc1.COC(=O)c1cc(Br)sc1NC(N)=O>>COC(=O)c1cc(-c2ccncc2)sc1NC(N)=O,[Cu]I,CN(C)C=O,,,,val
US20160060257A1,COC(=O)C(C)n1cc(N2CC=C(c3cc4c(-c5cc(F)ccc5OC)ccnc4[nH]3)CC2)cn1>>COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(c4cnn(C(C)C(=O)O)c4)CC3)cc12,,C1CCOC1,CO,[Li+].[OH-],,val
US20130005721A1,CCC(O)(c1cn(Cc2ccn3c(-c4ccc(F)cc4)c(C#N)cc3c2)nn1)C(F)(F)F.C[Si](C)(C)N=[N+]=[N-]>>CCC(O)(c1cn(Cc2ccn3c(-c4ccc(F)cc4)c(-c4nn[nH]n4)cc3c2)nn1)C(F)(F)F,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US20090137530A1,CC(C)(C)OC(=O)NC1(CCc2ccc(O)c(C(F)F)c2)COC(C)(C)OC1.CCCCCCCCBr>>CCCCCCCCOc1ccc(CCC2(NC(=O)OC(C)(C)C)COC(C)(C)OC2)cc1C(F)F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100120762A1,N=C(N)c1cccc(Cl)c1.O=C(CBr)C1CC1>>Clc1cccc(-c2nc(C3CC3)c[nH]2)c1,,CC(Cl)Cl,,,,val
US20160151506A1,CC(C)(C)OC(=O)NCCC(=O)O.C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO>>CC(C)(C)OC(=O)NCCC(=O)O.C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO,,CN(C)C=O,ClCCl,CCN=C=NCCCN(C)C,Cl,val
US20150166558A1,CC(=O)Nc1ccc(S(=O)(=O)N=[N+]=[N-])cc1.CCOC(=O)CC(=O)CCC1CCN(Cc2ccccc2)CC1>>CCOC(=O)C(=[N+]=[N-])C(=O)CCC1CCN(Cc2ccccc2)CC1,,CC#N,,CCN(CC)CC,,val
US20070185101A1,CN1O[C@H]2N(C(=O)OC(C)(C)C)[C@H](C(=O)O)C[C@@]2(OC(=O)OC(C)(C)C)c2cccc(Cl)c21>>CN1OC2N(C(=O)OC(C)(C)C)[C@H](C(=O)O)C[C@@]2(OC(=O)OC(C)(C)C)c2cccc(Cl)c21,[Pd],CCOC(C)=O,,[H][H],,val
US20070281938A1,CCOC(=O)C(Br)C(=O)OCC.NC(=S)Nc1ccccc1C(F)(F)F>>CCOC(=O)C1SC(Nc2ccccc2C(F)(F)F)=NC1=O,,CCO,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20090181942A1,COC(=O)c1cccc(C(F)(F)F)c1OC>>COc1c(C(=O)O)cccc1C(F)(F)F,,C1CCOC1,,CO,[Na+].[OH-],val
US20070276000A1,CCc1cc2cc(OC)ccc2c(O)c1-c1ccccc1.O=Cc1ccc(F)cc1>>CCc1cc2cc(OC)ccc2c(Oc2ccc(C=O)cc2)c1-c1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US20150232464A1,CCOC(=O)C(=O)c1cnn(C)c1.C[Mg]Br>>CCOC(=O)C(C)(O)c1cnn(C)c1,,C1CCOC1,,CCOCC,[Cl-].[NH4+],val
US04010182,Nc1ccc(F)cc1.O=C(O)/C(Cl)=C(/Cl)C(=O)O>>O=C1C(Cl)=C(Cl)C(=O)N1c1ccc(F)cc1,,O,,,,val
US20050054640A1,CC(=O)Cl.CCOCc1nc2c(N)nc3ccccc3c2n1NCCCN>>CCOCc1nc2c(N)nc3ccccc3c2n1NCCCNC(C)=O,,ClCCl,,CCN(CC)CC,,val
US20080045521A1,CC(C)(C)OC(=O)Nc1ccccn1.COC(=O)[C@H](Cc1ccc(OCCCBr)cc1)NC(=O)OC(C)(C)C>>COC(=O)[C@H](Cc1ccc(OCCCN(C(=O)OC(C)(C)C)c2ccccn2)cc1)NC(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20090048301A1,COc1cc(Nc2ncccc2-c2nnc(Nc3cccc(N)c3)[nH]2)cc(OC)c1.O=Cc1ccc2c(c1)OCO2>>COc1cc(Nc2ncccc2-c2nnc(Nc3cccc(NCc4ccc5c(c4)OCO5)c3)[nH]2)cc(OC)c1,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040248981A1,CC(C)(C)OC(=O)N1CCC(Oc2c(Cl)cc([N+](=O)[O-])cc2Cl)CC1>>CC(C)(C)OC(=O)N1CCC(Oc2c(Cl)cc(N)cc2Cl)CC1,[Zn],CC(=O)O,,,,val
US20030149001A1,Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(N4CC(C)N(C(=O)OC(C)(C)C)C(C)C4)cn3)ncc12.Cl>>Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(N4CC(C)NC(C)C4)cn3)ncc12.Cl,,Cl,,ClCCl,,val
US20150025252A1,CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C.CO.O=C(O)/C=C\C(=O)O>>CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C.O=C(O)C[C@H](O)C(=O)O,,CO,ClCCl,,,val
US06713482B2,Cl.Nc1ccccc1Nc1ccccn1.O=C(Cl)/C=C/c1cccc(Cl)c1>>Cl.Clc1cccc(/C=C/c2nc3ccccc3n2-c2ccccn2)c1,,CO,,,,val
US20050153981A1,COc1ccc(C(=O)CCl)cc1.Cl.Cl.O=C(CN1CCNCC1)c1ccccc1>>COc1ccc(C(=O)CN2CCN(CC(=O)c3ccccc3)CC2)cc1.Cl.Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140134235A1,Fc1ccc(CNCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(N(CC2CC2)CC2CC2)n1.N#CBr>>N#CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1ccc(F)nc1N(CC1CC1)CC1CC1,,CO,,O=C([O-])O.[Na+],,val
US20070105959A1,COCOc1cccc(B(O)O)c1.N#CCc1cccc(Br)c1>>COCOc1cccc(-c2cccc(CC#N)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O,O=C([O-])[O-].[Na+].[Na+],val
US04492702,C=CCc1c(OC(C)=O)c2cccnc2n(-c2ccccc2)c1=O>>C=CCc1c(O)c2cccnc2n(-c2ccccc2)c1=O,,CCO,,[Na+].[OH-],,val
US04521535,CCNC=C(C(=O)C=Cc1ccc(Cl)cc1)C(=O)OC>>CCN1C=C(C(=O)OC)C(=O)CC1c1ccc(Cl)cc1,,CN(C)C=O,,,,val
US20090105327A1,CCOC(=O)Cl.Nc1ccccc1Nc1ccc2c(c1)OCc1ccccc1C2=O>>CCOC(=O)Nc1ccccc1Nc1ccc2c(c1)OCc1ccccc1C2=O,,c1ccncc1,,,,val
US20100069381A1,CSc1ccc(Nc2cc(C(=O)NNC(=O)C(C)(C)OC(C)=O)ccn2)cc1>>CSc1ccc(Nc2cc(-c3nnc(C(C)(C)OC(C)=O)o3)ccn2)cc1,,c1ccncc1,,Cc1ccc(S(=O)(=O)Cl)cc1,,val
US05409956,CCOC(=O)CC(=O)c1ccc2c(c1)CC(CNS(=O)(=O)c1ccc(Cl)cc1)C2>>CCOC(=O)CC(O)c1ccc2c(c1)CC(CNS(=O)(=O)c1ccc(Cl)cc1)C2,,CCO,,[BH4-].[Na+],,val
US20120264734A1,CI.COC(=O)c1cc(Br)cc(NC2CCCCC2)c1C>>COC(=O)c1cc(Br)cc(N(C)C2CCCCC2)c1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110245224A1,CCOC(=O)c1noc2c(F)c(N3C[C@H](C)O[C@H](C)C3)c(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc12>>CCOC(=O)c1noc2c(F)c(N3C[C@H](C)O[C@H](C)C3)c(CO)cc12,,C1CCOC1,O,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20090233919A1,COc1cc(N2CCc3nc(-c4ccc(Cl)cc4)sc3C2=O)ccc1N1CCC(O)CC1.Cl>>COc1cc(N2CCc3nc(-c4ccc(Cl)cc4)sc3C2=O)ccc1N1CCC(O)CC1.Cl,,CO,,,,val
US20160152624A1,CCCC[Sn](CCCC)(CCCC)c1ccc(Cl)s1.CCOC(=O)c1ccc(-n2ccc3c(C)nc(Cl)nc32)cc1>>COC(=O)c1ccc(-n2ccc3c(C)nc(-c4ccc(Cl)s4)nc32)cc1,,CN(C)C=O,,ClCCl,,val
US20040192767A1,COc1ccc(-c2ccc(OCc3cc(C(=O)O)oc3C)cc2)c(OC)c1.NS(=O)(=O)c1ccccc1>>COc1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)c4ccccc4)oc3C)cc2)c(OC)c1,CN(C)c1ccncc1,C1CCOC1,CC#N,CCN=C=NCCCN(C)C,Cl,val
US20120110702A1,CC(C)C(=O)Cl.CNc1cnn(-c2cccnc2)c1>>CC(C)C(=O)N(C)c1cnn(-c2cccnc2)c1,,CC(Cl)Cl,,,,val
US20070238730A1,CC(C)(C)OC(=O)NCCc1nc(C2CC2)no1.Cl>>Cl.NCCc1nc(C2CC2)no1,,ClCCl,,,,val
US06350749B1,Cc1n[nH]c2c1C(=O)CC(c1sccc1Cl)C2.Cl.N=C(N)NN>>Cc1n[nH]c2c1C(=NNC(=N)N)CC(c1sccc1Cl)C2.Cl,,CCO,,Cl,O,val
US20080312231A1,COC(=O)CC1NCCc2ccccc21.O=S(=O)(Cl)c1ccc(Cl)c(Cl)c1>>COC(=O)CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1,,ClCCl,,CCN(CC)CC,Cl,val
US20040157866A1,CC(=O)OCc1ccc(C(=O)Nc2ccc3c(c2)CCN3C(=O)Cc2ccccn2)c(-c2ccc(C(F)(F)F)cc2)c1>>O=C(Nc1ccc2c(c1)CCN2C(=O)Cc1ccccn1)c1ccc(CO)cc1-c1ccc(C(F)(F)F)cc1,,C1CCOC1,CO,O,[Na+].[OH-],val
US20130178469A1,COC(=O)c1nc2c(NC(C)=O)cc(N3CCOCC3)cn2c(=O)c1OCc1ccccc1>>COC(=O)c1nc2c(NC(C)=O)cc(N3CCOCC3)cn2c(=O)c1O,,ClCCl,,Cl,,val
US05877317,CC(C(=O)Cl)c1ccccc1.O=C1N[C@@H](Cc2ccccc2)CO1>>CC(C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1)c1ccccc1,,C1CCOC1,,[Li]CCCC,O=C([O-])O.[Na+],val
US20130085164A1,CC(O)c1ccc(-c2ccc(=O)n(C)c2)s1.O=C(n1ccnc1)n1ccnc1>>CC(c1ccc(-c2ccc(=O)n(C)c2)s1)n1ccnc1,,CC#N,CCOC(C)=O,,,val
US20130261102A1,Brc1cnc2ccc(N3CCOCC3)nc2c1.Nc1nc2cc(B(O)O)ccc2o1>>Nc1nc2cc(-c3cnc4ccc(N5CCOCC5)nc4c3)ccc2o1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20080287396A1,CCOP(=O)(OCC)C(CCCOC(=O)c1cn(C2CC2)c2c(OC)c(N3CCN(C(=O)OC(C)(C)C)C(C)C3)c(F)cc2c1=O)P(=O)(OCC)OCC>>COc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)OCCCC(P(=O)(O)O)P(=O)(O)O)cn(C3CC3)c12,,ClCCl,,C[Si](C)(C)Br,,val
US20100022476A1,CCOc1cc(OC)c2c(Nc3cc(CC(=O)Nc4cccc(F)c4F)[nH]n3)ncnc2c1>>CCOc1cc(O)c2c(Nc3cc(CC(=O)Nc4cccc(F)c4F)[nH]n3)ncnc2c1,,c1ccncc1,,Cl,O=C([O-])O.[Na+],val
US20110046133A1,Cc1ccc(NC(=O)c2ccc(N)c(N)c2)cc1C.Cc1cccc(C=O)c1C>>Cc1ccc(NC(=O)c2ccc3nc(-c4cccc(C)c4C)[nH]c3c2)cc1C,,CS(C)=O,,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US04012392,CCOC(=O)C(C)(C)C(=O)Cl.CCOC(=O)CCNC>>CCOC(=O)CCN(C)C(=O)C(C)(C)C(=O)OCC,,c1ccncc1,,,,val
US20030073846A1,COCOc1ccc(C[C@H](N)C(C)(C)O)cc1.c1ccc(OC[C@@H]2CO2)cc1>>COCOc1ccc(C[C@H](NC[C@H](O)COc2ccccc2)C(C)(C)O)cc1,,CCO,,,,val
US06130217,C=C(C)CCO.Cc1nc2cccc(O)c2s1.O=C(OO)c1cccc(Cl)c1>>Cc1nc2cccc(OCCC3(C)CO3)c2s1,,ClCCl,,[Na+].[OH-],,val
US20110118251A1,Fc1ncccc1C1C=CCO1>>Fc1ncccc1C1CCCO1,[Pd],CO,,,,val
US20070066820A1,Cc1ccc(S(=O)(=O)OC[C@H]2CCCN2C(=O)OC(C)(C)C)cc1.Oc1ccc(Oc2ccc(F)cc2)cc1>>CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccc(Oc2ccc(F)cc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US07737166B2,CCOC(=O)C(OCC)(OCC)OCC.Cc1c(Br)c(F)c(O)c(N)c1C#N>>CCOC(=O)c1nc2c(C#N)c(C)c(Br)c(F)c2o1,,CCCCCC,,,,val
US20090198063A1,CC(C)(C)OC(=O)NC1CCN(CCn2c(=O)ccc3ncc(F)cc32)CC1>>NC1CCN(CCn2c(=O)ccc3ncc(F)cc32)CC1,,ClC(Cl)Cl,,CCO,Cl,val
US20050054683A1,Nc1ccc(C2(O)CN(C(c3ccccc3)c3ccccc3)C2)c(F)c1.O=C(Cl)OCc1ccccc1>>O=C(Nc1ccc(C2(O)CN(C(c3ccccc3)c3ccccc3)C2)c(F)c1)OCc1ccccc1,,CC(C)=O,O,O=C([O-])O.[Na+],,val
US20140142083A1,COC(=O)c1cc(Br)cc(N)c1Cl.O=C1CCCC1>>COC(=O)c1cc(Br)cc(NC2CCCC2)c1Cl,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20150087646A1,CC(C)(C)C(=O)Cl.NCc1ccc(Cl)c(-c2nn(-c3ccc(C#CC4CC4)cc3F)c(=O)[nH]2)c1>>CC(C)(C)C(=O)NCc1ccc(Cl)c(-c2nn(-c3ccc(C#CC4CC4)cc3F)c(=O)[nH]2)c1,,C1CCOC1,,,,val
US20090054469A1,Cc1ccc(N)cc1NC(=O)c1ccc2nc[nH]c(=O)c2c1>>Cc1ccc(N)cc1NC(=O)c1ccc2c(c1)C(=O)NCN2,[Pd],CO,,,,val
US20060116400A1,C=CCOC(=O)CCC.ON=C(Cl)c1ccc(Br)cn1>>CCCC(=O)OCC1CC(c2ccc(Br)cn2)=NO1,,CCOC(C)=O,,CCN(CC)CC,,val
US20140094459A1,N#CCC(=O)O.Nc1ncnc2c1c(-c1ccc(Oc3cc(F)cc(F)c3)cc1)nn2[C@@H]1CCCNC1>>N#CCC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4cc(F)cc(F)c4)cc3)c3c(N)ncnc32)C1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20160039834A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNC[C@@H](O)COc1cccc(Br)c1>>CN(C[C@@H](O)COc1cccc(Br)c1)C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20050038101A1,CCOC(=O)c1cc2cc([N+](=O)[O-])ccc2[nH]1.Fc1cccc(F)c1CCl>>O=C(O)c1cc2cc([N+](=O)[O-])ccc2n1Cc1c(F)cccc1F,,CS(C)=O,O,Cl,[K+].[OH-],val
US20060160864A1,CCCCOCCOc1ccc(-c2ccc(N3CCCCCC3)c(/C=C(\CC)C(=O)OCC)c2)cc1>>CCCCOCCOc1ccc(-c2ccc(N3CCCCCC3)c(/C=C(\CC)C(=O)O)c2)cc1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US04115416,CCCCCCCCCCC(Oc1ccc(C2=CCCCCCC2)cc1)C(=O)OCC>>CCCCCCCCCCC(Oc1ccc(C2=CCCCCCC2)cc1)C(=O)O,,CCO,,[Na+].[OH-],,val
US20070037836A1,CCN(CC)c1nc(N[C@@H]2CC[C@H](N)CC2)nc2ccccc12.Cl.ClCCl.O=CCc1ccc(Br)cc1OC(F)(F)F>>CN(C)c1nc(N[C@@H]2CC[C@H](NCCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12.Cl.Cl,,CCOC(C)=O,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04822400,CC1(C(=O)Cn2cncn2)COCOC1.Fc1ccccc1OCCCCBr>>CC1(C(=O)C(CCCCOc2ccccc2F)n2cncn2)COCOC1,,CN(C)C=O,,[H-].[Na+],,val
US20120115846A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.COc1ccc(Cn2c(=O)c3cc(I)ccc3n(C3CCOCC3)c2=O)cc1OC>>COc1ccc(Cn2c(=O)c3cc(C(C)=O)ccc3n(C3CCOCC3)c2=O)cc1OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20080132477A1,CN(C)C(=O)c1cc2cc(c1)C(=O)N[C@H]([C@H](O)CCl)Cc1cccc(c1)OCC=CCO2>>CN(C)C(=O)c1cc2cc(c1)C(=O)N[C@H]([C@H](O)CCl)Cc1cccc(c1)OCCCCO2,[Pd],CCO,,,,val
US20110201635A1,COC(=O)c1ccc(COC(=O)N2CC(CC(C)(C)C)C3(C(=O)Nc4cc(Cl)ccc43)C2c2cccc(Cl)c2F)cc1>>CC(C)(C)CC1CN(C(=O)OCc2ccc(C(=O)O)cc2)C(c2cccc(Cl)c2F)C12C(=O)Nc1cc(Cl)ccc12,,C1CCOC1,O,CO,[Li+].[OH-],val
US20080293723A1,COC(C)[Si](C)(C)C.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccc(F)cc1C1N(CC(=O)OC(C)(C)C)C(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12>>COC(C)[Si](C)(C)C.Cc1ccc(F)cc1C1N(CC(=O)OC(C)(C)C)C(=S)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12,,Cc1ccccc1,,,,val
US20080119473A1,CC(C)(C)OC(=O)c1cccc(C(=N)N)c1.Cc1ccc(C(=O)N=CN(C)C)cc1>>Cc1ccc(-c2ncnc(-c3cccc(C(=O)O)c3)n2)cc1,,CC(=O)O,,,,val
US20100016279A1,Brc1cccnc1.O=C1CCN(C(=O)OCc2ccccc2)CC1>>O=C(OCc1ccccc1)N1CCC(O)(c2cccnc2)CC1,,C1CCOC1,CCOCC,CCCCCC,[Li]CCCC,val
US20070078184A1,CS(=O)(=O)OCCOc1ccc(-c2ccc(C(=O)OCc3ccccc3)cc2)cc1.NCC(O)c1ccc(O)c(NC=O)c1>>O=CNc1cc(C(O)CNCCOc2ccc(-c3ccc(C(=O)OCc4ccccc4)cc3)cc2)ccc1O,,CN(C)C=O,,CCOC(C)=O,O,val
US20090215743A1,CCOC(=O)CC1OC(c2cccc3c2OCCO3)c2cc(Cl)ccc2NC1=O.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CCOC(=O)CC1OC(c2cccc3c2OCCO3)c2cc(Cl)ccc2NC1=S,,COCCOC,,O=C([O-])O.[Na+],,val
US20150274704A1,OC1CN(Cc2ccccc2)CC12CCCC2>>OC1CNCC12CCCC2,[Pd],CO,,,,val
US04859229,CC(C)Oc1cc(N)c(F)cc1Cl.CCOC(=O)Cl>>CCOC(=O)Nc1cc(OC(C)C)c(Cl)cc1F,,ClCCl,,c1ccncc1,,val
US20020188125A1,CCOC(C[C@H](CO)COC(C)=O)OCC.Cc1ccc(S(=O)(=O)Cl)cc1>>CCOC(C[C@@H](COC(C)=O)COS(=O)(=O)c1ccccc1C)OCC,,CCOC(C)=O,O,CCN(CC)CC,ClCCl,val
US05071999,CCOC(=O)N1CC2N(C)CCC2(CF)C1>>CN1CCC2(CF)CNCC12,,Cl,,,,val
US20110071115A1,O=C1CC(=P(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)N1.O=Cc1cnn2c(NC3CC3)cc(-c3cccc(CO)c3)nc12>>O=C1CC(=Cc2cnn3c(NC4CC4)cc(-c4cccc(CO)c4)nc23)C(=O)N1,,CCO,,,,val
US20140148340A1,FC(F)(F)Oc1ccc(-c2cncc(Cl)n2)cc1.O=Cc1ccc(B(O)O)cc1>>O=Cc1ccc(-c2cncc(-c3ccc(OC(F)(F)F)cc3)n2)cc1,[Pd],,,,,val
US20150225373A1,C#CC(C)(C)c1cc(N)n(-c2ccc(C)cc2)n1.O=C(Nc1ccc(Oc2ccnc(Nc3ccccc3)c2)c2ccccc12)Oc1ccccc1>>C#CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)c3)c3ccccc23)n(-c2ccc(C)cc2)n1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20090156610A1,C#C[Si](C)(C)C.N#Cc1ccc(Oc2ccc(I)cc2C2NC(=O)CC(c3cccc(Cl)c3)C23C(=O)Nc2cc(Cl)ccc23)cc1>>C#Cc1ccc(Oc2ccc(C#N)cc2)c(C2NC(=O)CC(c3cccc(Cl)c3)C23C(=O)Nc2cc(Cl)ccc23)c1,[Cu]I,CN(C)C=O,CO,CCN(CC)CC,[Na+].[OH-],val
US20130210824A1,Cc1ncc2c(-c3nc(I)c4c(n3)NC(=O)C4(C)C)nn(Cc3ccccc3F)c2n1>>Cc1ncc2c(-c3ncc4c(n3)NC(=O)C4(C)C)nn(Cc3ccccc3F)c2n1,[Pd],CN(C)C=O,,,,val
US20050027119A1,CC(=O)C(=O)O.Nc1ccc(F)c(F)c1F>>CC(Nc1ccc(F)c(F)c1F)C(=O)O,[Pd],CC(C)O,,[H][H],,val
US20120302809A1,CC(=Nc1ccccc1C(C)C)c1cccc(C(C)=Nc2c(C)cccc2C)n1.Cl[Fe]Cl>>CC(=Nc1ccccc1C(C)C)c1cccc(C(C)=Nc2c(C)cccc2C)n1.Cl[Fe]Cl,,C1CCOC1,,,,val
US20090124695A1,CCCCCC(C)(/C=C/[C@H]1[C@H](OC(=O)c2ccccc2)C[C@@H]2OC(=O)C[C@@H]21)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C>>CCCCCC(C)(/C=C/[C@H]1[C@H](O)C[C@@H]2OC(=O)C[C@@H]21)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20100216786A1,Cc1ccc(S(=O)(=O)ON)cc1.N#Cc1c(N)nc2ccc(I)cc2c1O>>Cc1ccc(S(=O)(=O)[O-])cc1.N#Cc1c(O)c2cc(I)ccc2[n+](N)c1N,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20070232594A1,COC(=O)c1ccc(OCCOCc2ccccc2)cc1Cl>>O=C(O)c1ccc(OCCOCc2ccccc2)cc1Cl,,CO,,Cl,[Na+].[OH-],val
US20140275085A1,CCNc1ncc(-c2ccc(Oc3ccnc(Cl)c3)cn2)c(OC)n1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>CCNc1ncc(-c2ccc(Oc3ccnc(-c4cnn(C)c4)c3)cn2)c(OC)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20090091243A1,Cc1cc2c(c(C#CCO)c1C)Cc1ccccc1-2>>C#Cc1cccc2c1Cc1ccccc1-2,,CCCCCC,,Cc1ccccc1,[Na+].[OH-],val
US20130085128A1,CCOC(=O)c1cc(Br)nc2c1c(C)nn2C1CCCCO1.OB(O)c1ccc(OCc2ccccc2)cc1F>>CCOC(=O)c1cc(-c2ccc(OCc3ccccc3)cc2F)nc2c1c(C)nn2C1CCCCO1,,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20040209892A1,c1ccc(COc2ccc(Oc3ccnc4[nH]ccc34)cc2)cc1>>Oc1ccc(Oc2ccnc3[nH]ccc23)cc1,[Pd],CO,,,,val
US20140045872A1,C[N+](=O)[O-].Cc1cccc(C=O)c1>>Cc1cccc(/C=C/[N+](=O)[O-])c1,,CCO,,[Na+].[OH-],,val
US20050250818A1,COC(=O)c1ccc([C@H](C)NC(=O)c2cc(Cl)ccc2O)cc1.OCCc1c(F)cccc1F>>COC(=O)c1ccc([C@H](C)NC(=O)c2cc(Cl)ccc2OCCc2c(F)cccc2F)cc1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100093757A1,COC(=O)[C@H](COCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)Oc1ncnc2c1cnn2-c1ncccc1Cl.N#Cc1ccc(N)nc1>>CC(C)(C)[Si](OCCOC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(C#N)cn1)(c1ccccc1)c1ccccc1,,Cc1ccccc1,,C[Al](C)C,,val
US20100152213A1,CI.Cc1cccc2c(=O)n(-c3ccccc3)c(S)nc12>>CSc1nc2c(C)cccc2c(=O)n1-c1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080188528A1,Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)c2cccn(C3c4ccccc4-c4ccccc43)c2=O)C(=O)OC(C)(C)C)c(C)c2c1OC(C)(C)CC2.O=C(O)C(F)(F)F>>N=C(N)NCCC[C@H](NC(=O)c1cccn(C2c3ccccc3-c3ccccc32)c1=O)C(=O)O.O=C(O)C(F)(F)F,,O,,CC[SiH](CC)CC,,val
US20100184649A1,CC(C)c1ccc(CCCC(=O)O)cc1>>CC(C)C1CCC(CCCC(=O)O)CC1,O=[Pt]=O,CC(=O)O,,,,val
US20030139393A1,C1CNCCC2(C1)OCCO2.COc1ccc(CCBr)cc1>>COc1ccc(CCN2CCCC3(CC2)OCCO3)cc1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20160155949A1,Clc1ccc2ccc3ccc(Cl)nc3c2n1.OB(O)c1ccccc1>>Clc1ccc2ccc3ccc(-c4ccccc4)nc3c2n1,,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US04122179,CCCCCC(=O)O.CC[C@@]12C=C(C(=O)OC)n3c4c(c5ccccc53)CCN(CCC1)[C@H]42>>CCCCCC(=O)[O-].CC[C@@]12C=C(C(=O)OC)n3c4c(c5ccccc53)CCN(CCC1)[C@H]42,,O,,,,val
US20120264704A1,CCO.N#CCc1ccc(Cl)nc1.O=C([O-])O>>CCOC(=O)Cc1ccc(Cl)nc1,,O,,O=S(=O)(O)O,,val
US07714010B2,CCCCCN1C(=O)C(C)(C)c2cc(N)c([N+](=O)[O-])cc21.O=C(Cl)/C=C/c1ccccc1[N+](=O)[O-]>>CCCCCN1C(=O)C(C)(C)c2cc(NC(=O)/C=C/c3ccccc3[N+](=O)[O-])c([N+](=O)[O-])cc21,,ClCCl,,,,val
US20070149579A1,Cc1ccc2c(-c3ccc(F)cc3)cc(=O)oc2c1.O=C1CCC(=O)N1Br>>O=c1cc(-c2ccc(F)cc2)c2ccc(CBr)cc2o1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20150274704A1,CC(C)(C)OC(=O)N1CCC2(CCC(Nc3nc(Cl)ncc3Cl)CC2)CC1.Cn1cc(N)cn1>>Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(C(=O)OC(C)(C)C)CC4)n2)cn1,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20150183801A1,O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(Br)c(-c2cncnc2)c1.O=C1NCCO1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2CCOC2=O)c(-c2cncnc2)c1,I[Cu]I,C1COCCO1,CCOC(C)=O,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20120184735A1,COc1c(C(O)C(F)(F)F)cc(C(C)(C)C)cc1[N+](=O)[O-]>>COc1c(C(=O)C(F)(F)F)cc(C(C)(C)C)cc1[N+](=O)[O-],,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090130076A1,CCOP(=O)(Cl)OCC.COc1c(CO)cc2sc(NC(=O)OC(C)(C)C)nc2c1-c1cccc([N+](=O)[O-])c1>>CCOP(=O)(OCC)OCc1cc2sc(NC(=O)OC(C)(C)C)nc2c(-c2cccc([N+](=O)[O-])c2)c1OC,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,,val
US05334576,CC(=O)c1cc2c(nc1C)C1=NC(C)(C(C)C)C(=O)N1C2=O.OCc1ccco1>>CC(=O)c1cc(C(=O)OCc2ccco2)c(C2=NC(C)(C(C)C)C(=O)N2)nc1C,,C1CCOC1,,CC(=O)O,[H-].[Na+],val
US20100286148A1,COC(c1ccnc(C#N)c1)C(F)(F)F.NO>>COC(c1ccnc(C(N)=O)c1)C(F)(F)F,,CCO,,Cl,O=C([O-])O.[Na+],val
US20080200444A1,CC(C)(C)OC(=O)N1CCCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)C1.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=C(NC1CCCN(S(=O)(=O)c2ccc(Cl)cc2)C1)NC12CC3CC(CC(C3)C1)C2,,C1COCCO1,CO,CCN(CC)CC,Cl,val
US20120046267A1,CI.S=c1[nH]c2cccc(Br)c2s1>>CSc1nc2cccc(Br)c2s1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20110172202A1,C=CS(C)(=O)=O.CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N>>CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NCCS(C)(=O)=O)no2)cc1C#N,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20030036557A1,CCN(CC)S(F)(F)F.CS(=O)(=O)c1ccc(-n2cc(CO)nc2-c2ccc(Cl)cc2)cc1>>CS(=O)(=O)c1ccc(-n2cc(CF)nc2-c2ccc(Cl)cc2)cc1,,ClCCl,,O,,val
US20080293720A1,N#Cc1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1.[N-]=[N+]=[N-]>>O=S(=O)(Nc1cc(Cl)cnc1Oc1ccc(-c2nnn[nH]2)cc1)c1ccc(Cl)c(Cl)c1,,CN(C)C=O,,[Cl-].[NH4+],,val
US05059689,C1COCCN1.CC1(C)CC2(CC(C)(C)N1c1nc(Cl)nc(Cl)n1)OCCO2>>CC1(C)CC2(CC(C)(C)N1c1nc(Cl)nc(N3CCOCC3)n1)OCCO2,,Cc1ccccc1,O,[Na+].[OH-],,val
US06008213,CCOC(=O)CC1Cc2ccc(O)cc2Cc2ccccc21.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)CC1Cc2ccc(OS(=O)(=O)C(F)(F)F)cc2Cc2ccccc21,,CCOCC,ClCCl,Cc1cccc(C)n1,,val
US20160272628A1,CC(C)(C)OC(=O)CBr.CC1NS(=O)(=O)c2ccc(Br)cc21>>CC1c2cc(Br)ccc2S(=O)(=O)N1CC(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090093485A1,C[C@@H](CO)N1C(=O)c2ccccc2C1=O.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC[C@H](C)N2C(=O)c3ccccc3C2=O)cc1,,c1ccncc1,,,,val
US05332741,N#CCCl.Oc1cccc2c1SCCC2>>N#CCOc1cccc2c1SCCC2,,CN(C)C=O,,[I-].[K+],,val
US20150225381A1,CC(C)(C)[Si](C)(C)OC1(CO)CC1.CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1c1ccc(O)c(F)c1>>CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1c1ccc(OCC2(O[Si](C)(C)C(C)(C)C)CC2)c(F)c1,,CO,Cc1ccccc1,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US05969138,CCOC(=O)OCC.O=C1CCCN1c1ccc(Cl)cc1>>CCOC(=O)C1CCN(c2ccc(Cl)cc2)C1=O,,C1CCOC1,CCCCCC,Cl,[H-].[Na+],val
US20050143380A1,BrBr.Cc1cccc(N)n1>>Br.Cc1nc(N)ccc1Br,,CC(=O)O,,,,val
US20030018045A1,CC(C)(C)[Si](Oc1ccc(OCC2CO2)cc1)(c1ccccc1)c1ccccc1.COc1cc(OCCCOc2ccccc2)ccc1CCNC(=O)N1CCC(Nc2ccc(CCN)cc2)CC1>>COc1cc(OCCCOc2ccccc2)ccc1CCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1,,CO,ClC(Cl)Cl,O=CO,,val
US20140155421A1,CCOC(=O)c1cc(-c2ccnc(N)n2)[nH]c1Br.OB(O)c1cc(C(F)(F)F)ccc1Cl>>CCOC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1cc(C(F)(F)F)ccc1Cl,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,Cc1ccccc1,[Cl-].[Na+],O=C([O-])[O-].[Li+],val
US20020156081A1,CCOC(=O)C1(C(=O)OCC)CC(OS(C)(=O)=O)C1.Nc1ncnc2[nH]nc(-c3ccc(Oc4ccccc4)cc3)c12>>CCOC(=O)C1(C(=O)OCC)CC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20060040965A1,C=CCN.N#CCC#N.O=C(c1ccccc1)C(O)c1ccccc1>>C=CCn1c(N)c(C#N)c(-c2ccccc2)c1-c1ccccc1,,CCOC(C)=O,Cc1ccccc1,,,val
US20080139639A1,CCCCc1cc(C(=O)OCC)c[nH]1.O=S(=O)(Cl)c1ccccc1>>CCCCc1cc(C(=O)OCC)cn1S(=O)(=O)c1ccccc1,,C1CCOC1,,O,[H-].[Na+],val
US06486156B1,COC(=O)c1ccc(/C=C/Cc2ncc[nH]2)cc1-c1ccc(F)cc1>>O=C(O)c1ccc(/C=C/Cc2ncc[nH]2)cc1-c1ccc(F)cc1,,CO,O,[Na+].[OH-],,val
US20130150376A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@H]1CC(=O)CCN1C(=O)OCc1ccccc1>>C[C@H]1CC(=O)CCN1C(=O)OC(C)(C)C,[Pd],C1CCOC1,,CCO,,val
US05569664,CCOP(=O)(OCC)c1ccc(CO)cc1.O=S(Cl)Cl>>CCOP(=O)(OCC)c1ccc(CCl)cc1,c1ccncc1,ClCCl,,,,val
US20080269208A1,CC(=O)OC[C@H]1CN2CCN(c3cc(-c4ccc(F)cc4C)c(N(C)C(=O)C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)cn3)CC2CN1C(C)=O>>CC(=O)N1CC2CN(c3cc(-c4ccc(F)cc4C)c(N(C)C(=O)C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)cn3)CCN2C[C@@H]1CO,,C1CCOC1,O,[Na+].[OH-],,val
US04067723,Br[Mg]c1ccccc1.O=Cc1ccco1>>OC(c1ccccc1)c1ccco1,,CCOCC,,,,val
US05241067,CC(=O)OC(C)=O.CCOC(=O)c1ccc2c(c1)C(=O)N(C1CC(C)(C)NC(C)(C)C1)C2=O>>CCOC(=O)c1ccc2c(c1)C(=O)N(C1CC(C)(C)N(C(C)=O)C(C)(C)C1)C2=O,CN(C)c1ccncc1,,,,,val
US20050085467A1,C1CCNCC1.Cn1c(=O)cc(C(F)(F)F)c2cc(S(=O)(=O)Cl)ccc21>>Cn1c(=O)cc(C(F)(F)F)c2cc(S(=O)(=O)N3CCCCC3)ccc21,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US04443245,C=CCBr.NS(=O)(=O)c1ccccc1O>>C=CCOc1ccccc1S(N)(=O)=O,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040092546A1,O=C(Cl)c1cccnc1Cl.c1cc[nH]c1>>O=C(c1ccc[nH]1)c1cccnc1Cl,,CCOC(C)=O,ClCCl,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05162360,C#CCN(CCCC)CCCC.N#COc1ccccc1>>CCCCN(CC#CC#N)CCCC,,CCOCC,,[Li]CCCC,,val
US20060100246A1,COc1ccc(COc2cccc(N)c2-c2cc(C3CCCN(C(=O)OC(C)(C)C)C3)c(C#N)c(N)n2)cc1.O=Cc1ccccc1>>COc1ccc(COc2cccc(NCc3ccccc3)c2-c2cc(C3CCCN(C(=O)OC(C)(C)C)C3)c(C#N)c(N)n2)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US05817700,CSc1ccc(C#Cc2ccccc2)cc1.O=C(Cl)C(Cl)(Cl)Cl>>CSc1ccc(C2=C(c3ccccc3)C(=O)C2(Cl)Cl)cc1,,CCOCC,,,,val
US20100009969A1,CC1CCCN1CCCOc1ccc(-c2nc3c(s2)CCCN3)cc1.CCN=C=O>>CCNC(=O)N1CCCc2sc(-c3ccc(OCCCN4CCCC4C)cc3)nc21,,ClCCl,,O,O=C([O-])[O-].[K+].[K+],val
US20100190814A1,CCC(CC)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)Nc1cc(Cl)ccc12)C(=O)NS(C)(=O)=O.COCCOC(=O)Cl>>CCC(CC)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)N(C(=O)OCCOC)c1cc(Cl)ccc12)C(=O)NS(C)(=O)=O,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,,,val
US20040171881A1,CCCCc1c[nH]c2ccc(C(=O)O)cc12.CCc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1>>CCCCc1c[nH]c2ccc(C(=O)N[C@@H](Cc3cc(F)cc(F)c3)[C@H](O)CNCc3cccc(CC)c3)cc12,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05763458,Nc1c(Cl)cc(C(=O)C=Cc2ccncc2)c2c1OCCO2>>Nc1c(Cl)cc(CCCc2ccncc2)c2c1OCCO2,[Pd],C1CCOC1,,,,val
US20130090309A1,COC(=O)c1ccc2c(c1)CCC[C@]2(O)c1ncc(-c2cc(C)cc(Nc3cc(C(F)(F)F)ccn3)n2)s1>>Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc(C3(O)CCCc4cc(C(=O)O)ccc43)s2)c1,,CCO,,Cl,[Li+].[OH-],val
US04544664,C[Si](C)(C)n1ccnc1.Cc1cccc(C)c1C(C)Cl>>Cc1cccc(C)c1C(C)c1c[nH]cn1,Cl[Ti](Cl)(Cl)Cl,ClC(Cl)Cl,,,,val
US20080076771A1,Nc1csc(-c2ccc(F)cc2F)n1.O=C(Cl)c1ccc(Nc2ccncn2)cc1>>O=C(Nc1csc(-c2ccc(F)cc2F)n1)c1ccc(Nc2ccncn2)cc1,,c1ccncc1,,Cl,,val
US20050272784A1,CC(=O)c1ccc(-c2ccccc2)cc1.CCOC(=O)C(=O)OCC>>CCOC(=O)C(=O)CC(=O)c1ccc(-c2ccccc2)cc1,,[Cl-],[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100087448A1,CC(=O)Nc1ncc(C(=N)N)s1.CCOC(=O)CC(C)=O.O=Cc1ccc(F)cc1Cl>>CCOC(=O)C1=C(C)NC(c2cnc(NC(C)=O)s2)=NC1c1ccc(F)cc1Cl,,CCO,,CC(=O)O,CC(=O)[O-].[Na+],val
US05998452,CC(C)c1cc(C=O)cc(C(C)C)c1O.NCCCO.O=C(O)CS>>CC(C)c1cc(C2SCC(=O)N2CCCO)cc(C(C)C)c1O,,c1ccccc1,,,,val
US20160022640A1,BrP(Br)Br.Cc1cc(CO)n(-c2ccccc2)n1>>Cc1cc(CBr)n(-c2ccccc2)n1,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20150111877A1,CC(=O)OC(C)=O.Cc1cccc(S(=O)(=O)N2CC(N)COc3ncc(NC(=O)c4c(Cl)cccc4Cl)cc32)c1>>CC(=O)NC1COc2ncc(NC(=O)c3c(Cl)cccc3Cl)cc2N(S(=O)(=O)c2cccc(C)c2)C1,,c1ccncc1,,,,val
US20090029994A1,CCOC(=O)CCCOc1cnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)ccc2O)nc1.O=C1CCC(=O)N1Br>>CCOC(=O)CCCOc1cnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)cc(Br)c2O)nc1,,ClC(Cl)Cl,,,,val
US20080194549A1,COC(=O)c1ccc(OC)c(O)c1.COCCCBr>>COCCCOc1cc(C(=O)OC)ccc1OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04565813,CC1=C(c2ccncc2)SCC(=O)N1.Cc1ccc(S(=O)(=O)O)cc1>>CC1=C(c2ccncc2)SCC(=O)N1.Cc1ccc(S(=O)(=O)O)cc1,,CO,,O,,val
US20080287437A1,COc1cc(N)n[nH]1.Clc1ncc(Cl)c(Cl)n1>>COc1cc(Nc2nc(Cl)ncc2Cl)n[nH]1,,CCO,,CCN(CC)CC,,val
US20080287479A1,CC1CCC(C(=O)CCl)CC1.CS(=O)(=O)c1ccc2c(c1)[nH]c(=O)n2C1CCNCC1>>CC1CCC(C(=O)CN2CCC(n3c(=O)[nH]c4cc(S(C)(=O)=O)ccc43)CC2)CC1,,CN(C)C=O,O,O=C(O)C(F)(F)F,,val
US20110166116A1,CC(C)(C)OC(=O)N1CCC(ON=C2CCNCC2)CC1.Fc1cc(F)c(Br)cc1F>>CC(C)(C)OC(=O)N1CCC(ON=C2CCN(c3cc(F)c(Br)cc3F)CC2)CC1,,CCOC(C)=O,CS(C)=O,CCN(C(C)C)C(C)C,Cl,val
US20160122358A1,CC(C)(C)NC(=O)N1CCn2nc(I)c(C(=O)O)c2C1.[NH4+]>>CC(C)(C)NC(=O)N1CCn2nc(I)c(C(N)=O)c2C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090270350A1,COC(=O)c1ccc(C)c(-n2c(SC)nc(OCc3ccccc3CN)cc2=O)c1.Cc1ccc(-n2nc(C(C)(C)C)cc2N)cc1.O=C(Cl)Cl>>COC(=O)c1ccc(C)c(-n2c(SC)nc(OCc3ccccc3CNC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)cc2=O)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US20110034507A1,CCOC(=O)c1cccc(Nc2cccc3nc(CCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)oc23)c1>>CC(C)c1onc(-c2c(Cl)cccc2Cl)c1CCc1nc2cccc(Nc3cccc(C(=O)O)c3)c2o1,,C1CCOC1,,[Li+].[OH-],,val
US06787541B1,NCCNc1nc(C(=O)c2cccs2)c2sccc2n1.S=C=Nc1ccccc1>>O=C(c1cccs1)c1nc(NCCNC(=S)Nc2ccccc2)nc2ccsc12,,CN(C)C=O,,O,,val
US05451700,COc1cc(C(=O)O)ccc1OCCCCCOc1ccc(C#N)cc1.O=S(Cl)Cl>>COc1cc(C(=O)Cl)ccc1OCCCCCOc1ccc(C#N)cc1,,ClCCl,,CN(C)C=O,,val
US20160096827A1,COc1cc(N)ccc1N1CCN(CC(F)F)CC1.N#Cc1cc(-c2ncnc(Cl)n2)ccc1OC1CCOCC1>>COc1cc(Nc2ncnc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)ccc1N1CCN(CC(F)F)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20050124692A1,BrCc1ccccc1.C=CCc1cc(Cl)c2ccccc2c1O>>C=CCc1cc(Cl)c2ccccc2c1OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20120328565A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(N)=O.O=C=NCc1ccc(Br)cc1>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NC(=O)NCc1ccc(Br)cc1,,Cc1ccccc1,,CCCCCC,CCOC(C)=O,val
US05008263,Cc1cc2c(cc1C)NC(=S)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2.NN>>Cc1cc2c(cc1C)N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(NN)=N2,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20070249659A1,COC(=O)c1ccc(CC(F)(F)c2ccccn2)cc1>>O=C(O)c1ccc(CC(F)(F)c2ccccn2)cc1,,CO,,Cl,[Na+].[OH-],val
US20100120761A1,CC(=O)Cl.O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cccc(OC5CCNCC5)c4)ccn23)c1>>CC(=O)N1CCC(Oc2cccc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)c2)CC1,,CN(C)C=O,,CCN(CC)CC,,val
US20160009744A1,BrP(Br)Br.Cc1oc(C=O)cc1CO[Si](C)(C)C(C)(C)C>>Cc1oc(C=O)cc1CBr,,C1COCCO1,ClCCl,C1CCOC1,Cl,val
US20120289493A1,COC(=O)c1coc(Cn2cnc3ccc(-c4ccc(OC(F)(F)F)cc4)cc3c2=O)n1>>O=C1c2cc(-c3ccc(OC(F)(F)F)cc3)ccc2NCN1Cc1nc(CO)co1,,C1CCOC1,,,,val
US20020013466A1,CCOC(=O)/C=C(\N)C(F)(F)F.CCOC(=O)COc1ccccc1Oc1cc(NC(=O)OCC)c(F)cc1Cl>>CCOC(=O)COc1ccccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(F)cc1Cl,,CN(C)C=O,,Cl,[H-].[Na+],val
US20100113462A1,CCOC(=O)C1(NC(=O)c2cccc3c2CN(C(=O)OC(C)(C)C)CC3)Cc2ccccc2C1>>CC(C)(C)OC(=O)N1CCc2cccc(C(=O)NC3(C(=O)O)Cc4ccccc4C3)c2C1,,CCO,,O,[K+].[OH-],val
US20110218193A1,COCn1c(=O)c2cccnc2c2cc(CC(C)=O)ccc21>>COCn1c(=O)c2cccnc2c2cc(CCCO)ccc21,,C1CCOC1,,B,CSC,val
US20120232051A1,CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1I.OB(O)c1cccnc1OCC(F)(F)F>>CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1-c1cccnc1OCC(F)(F)F,,CCCCCCC,CCOC(C)=O,,,val
US20110245205A1,CC(C)(CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)c1ncc(-c2cccc(Nc3nccc(C(F)(F)F)n3)c2)s1>>CC(C)(CO)c1ncc(-c2cccc(Nc3nccc(C(F)(F)F)n3)c2)s1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050267093A1,COc1cc(N)ccc1OCCN1CCC[C@H]1CO.O=C(O)C#Cc1ccc(C(F)(F)F)cc1Cl>>COc1cc(NC(=O)C#Cc2ccc(C(F)(F)F)cc2Cl)ccc1OCCN1CCC[C@H]1CO,,CO,ClCCl,,,val
US20110269742A1,COC(=O)C1CCN(S(=O)(=O)c2ccc(-c3ccccn3)cc2)CC1>>O=C(O)C1CCN(S(=O)(=O)c2ccc(-c3ccccn3)cc2)CC1,,Cl,,,,val
US20090149456A1,Nc1ccc2c(c1)CC(NC(=O)C(F)(F)F)C2.O=C(Cc1cccs1)Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3cccc(-c4cnco4)c3)n2)c1>>O=C(Cc1cccs1)Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc4c(c3)CC(NC(=O)C(F)(F)F)C4)n2)c1,,CC(C)O,,CCOCC,Cl,val
US04014677,CCC(C)N.Cc1nc(Cl)nc(Cl)c1[N+](=O)[O-]>>CCC(C)Nc1nc(Cl)nc(C)c1[N+](=O)[O-],,CCO,,CCN(CC)CC,,val
US20110166182A1,Cl.N#Cc1sccc1-c1ccc2cc(O)ccc2c1Oc1ccc(OCCN2CCCCC2)cc1>>Cl.N#Cc1sccc1-c1ccc2cc(O)ccc2c1Oc1ccc(OCCN2CCCCC2)cc1,,ClCCl,,CCOCC,,val
US05516806,CC(C)(C)OC(=O)N1C(=O)C2CCC1C2>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](CO)C1,,CO,,CC(=O)O,[BH4-].[Na+],val
US20080275037A1,COc1ncc([C@@H](C)N)cn1.Cc1ccc(N2CCc3ncnc(Cl)c3C2)c(C#N)c1>>COc1ncc([C@@H](C)Nc2ncnc3c2CN(c2ccc(C)cc2C#N)CC3)cn1,,CC#N,,CCN(C(C)C)C(C)C,,val
US04919708,CI.COc1cc(-n2nc(C(F)F)[nH]c2=O)c(F)cc1Cl>>COc1cc(-n2nc(C(F)F)n(C)c2=O)c(F)cc1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060135488A1,COC(=O)CS.COC(=O)c1sc2cc(C(=O)OC(C)(C)C)ccc2c1OS(=O)(=O)C(F)(F)F>>COC(=O)CSc1c(C(=O)OC)sc2cc(C(=O)OC(C)(C)C)ccc12,,CCN(CC)CC,ClCCl,O,,val
US06451801B1,C#CCCO.CC(Br)COc1ccc(I)cc1>>CC(Br)COc1ccc(C#CCCO)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,ClCCl,,CCN(CC)CC,,val
US20090186905A1,CC(C)(C)OC(=O)CBr.Oc1ccc(OC(F)(F)F)cc1>>CC(C)(C)OC(=O)COc1ccc(OC(F)(F)F)cc1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100009977A1,CC(=O)c1ccsc1S(N)(=O)=O.O=C1CCC(=O)N1Br>>NS(=O)(=O)c1sccc1C(=O)CBr,,CC#N,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20160075692A1,NC(=O)CBr.O=c1[nH]ccn1-c1cccc2c1cnn2-c1ccccc1F>>NC(=O)Cn1ccn(-c2cccc3c2cnn3-c2ccccc2F)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20050130954A1,C=O.CN[C@H](Cc1ccccc1)C(=O)N1CCN(c2ncnc3ccccc23)CC1>>CN(C)[C@H](Cc1ccccc1)C(=O)N1CCN(c2ncnc3ccccc23)CC1,,ClCCCl,,O=C([O-])O.[Na+],,val
US20060148856A1,O=[N+]([O-])c1cc(C2CC2)ccc1Nc1cccc(-c2nccs2)c1>>Nc1cc(C2CC2)ccc1Nc1cccc(-c2nccs2)c1,[Ni],CCO,,,,val
US05658854,COC(=O)c1cccc(NC=O)c1SCc1ccccc1>>CNc1cccc(C(=O)OC)c1SCc1ccccc1,,ClC(Cl)Cl,,CO,,val
US20100041728A1,CCOCOC1CC2C(=O)NC3(C(=O)NS(=O)(=O)C4CC4)CC3C=CCCCCCN(Cc3ccc(OC)cc3)C(=O)N2C1>>O=C1NC2(C(=O)NS(=O)(=O)C3CC3)CC2C=CCCCCCNC(=O)N2CC(O)CC12,,C1CCOC1,CO,Cl,O=C([O-])O.[Na+],val
US20070167507A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.CCOC(=O)c1cn(-c2ccccc2)nc1N>>CCOC(=O)c1cn(-c2ccccc2)nc1NC1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060106102A1,CN(C)C=O.COc1ccc(Br)c(C)c1>>COc1ccc(C=O)c(C)c1,,C1CCOC1,,II,[Mg],val
US20030087926A1,C=Cc1ccc(C)cc1.CCC(=O)C(=O)[O-].Nc1cc(Cl)cc(Cl)c1>>CCOC(=O)C1CC(c2ccc(C)cc2)c2c(Cl)cc(Cl)cc2N1,,CC#N,,O=C(O)C(F)(F)F,,val
US20110312908A1,Cc1nn(C)c(C)c1B1OC(C)(C)C(C)(C)O1.FC(F)(F)Oc1ccc(Nc2cc(Cl)ncn2)cc1>>Cc1nn(C)c(C)c1-c1cc(Nc2ccc(OC(F)(F)F)cc2)ncn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,O,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20040224960A1,Cc1cnc2nc(C=O)nn2c1.N#CC1(c2ccc(CCC3(C4CCCC4)CC(=O)CC(=O)O3)cc2F)CCC1>>Cc1cnc2nc(CC3=C(O)CC(CCc4ccc(C5(C#N)CCC5)c(F)c4)(C4CCCC4)OC3=O)nn2c1,,CO,,,,val
US20120108582A1,C[C@H](c1ccccc1)N1C[C@@](CCCO[Si](C)(C)C(C)(C)C)(C(=O)OC(C)(C)C)C(F)C1=O>>C[C@H](c1ccccc1)N1C[C@@](CCCO)(C(=O)OC(C)(C)C)C(F)C1=O,,C1CCOC1,,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20130211069A1,C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO>>C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO,,CC#N,,C[Si](C)(C)I,,val
US20140228360A1,CCOC(=O)CBr.O=C1COc2cccc(O)c2N1>>CCOC(=O)COc1cccc2c1NC(=O)CO2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130059835A1,CCOc1c(C(C)Cl)cc(Cl)c(C#N)c1Br.Nc1ncnc2[nH]ccc(=O)c12>>CCOc1c(C(C)n2ccc(=O)c3c(N)ncnc32)cc(Cl)c(C#N)c1Br,,CN(C)C=O,ClCCl,[H-].[Na+],,val
US20040097589A1,CCc1c(OC(=O)C=Cc2ccccc2)cc(Cl)c(Oc2ccc([N+](=O)[O-])cc2)c1Cl>>CCc1c(OC(=O)C=Cc2ccccc2)cc(Cl)c(Oc2ccc(N)cc2)c1Cl,,CCO,,CCOC(C)=O,,val
US03997555,CCC(O)CNN.CN(C)C=C(C=O)c1cccc(C(F)(F)F)c1>>CCC(O)Cn1cc(-c2cccc(C(F)(F)F)c2)cn1,,c1ccccc1,,,,val
US20090093417A1,CC(C)CC(C(=O)O)C(=O)NOC(=O)C(C)(C)C.CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(=O)OC>>CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)C(=O)N1C[C@@H](NC(=O)C(CC(C)C)C(=O)NOC(=O)C(C)(C)C)C[C@H]1C(=O)OC,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100168418A1,CCOC(=O)/C=C/c1cc(=O)n(CCN2CCC(N(Cc3ccc4c(c3)OCCO4)C(=O)OC(C)(C)C)CC2)c2cc(OC)ccc12>>CCOC(=O)/C=C/c1cc(=O)n(CCN2CCC(NCc3ccc4c(c3)OCCO4)CC2)c2cc(OC)ccc12,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20060009453A1,CNc1nccc(-c2cccnc2Sc2ccc(N)cc2)n1.O=C(OO)c1cccc(Cl)c1>>CNc1nccc(-c2cccnc2S(=O)c2ccc(N)cc2)n1,,ClCCl,,,,val
US20110105462A1,CCCNCCC.Cc1ccc(S(=O)(=O)OCC2COc3ccc(OS(C)(=O)=O)cc3O2)cc1>>CCCN(CCC)CC1COc2ccc(OS(C)(=O)=O)cc2O1,,CC#N,,,,val
US20020082428A1,BrBr.Cc1ccc(O)c(-n2nc3ccccc3n2)c1>>Oc1ccc(CBr)cc1-n1nc2ccccc2n1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20060235029A1,CSc1nc(-c2cc(N)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1.O=C(Cl)c1cccs1>>CSc1nc(-c2cc(NC(=O)c3cccs3)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20020143030A1,CCOC(=O)c1cnc2cc(F)ccc2c1O.COS(=O)(=O)OC>>CCOC(=O)c1cn(C)c2cc(F)ccc2c1=O,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06191150B1,C[C@H](CCNCN=N[N+](=O)[O-])[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1nccs1.Cl>>C[C@H](CCNCN=N[N+](=O)[O-])[C@H](N)C(=O)Nc1nccs1.Cl,,C1CCOC1,C1COCCO1,,,val
US20120101079A1,C1CCNC1.Cc1cc(N2CCOCC2)nc(Cl)c1C(=O)NCc1cccc(F)c1>>Cc1cc(N2CCOCC2)nc(N2CCCC2)c1C(=O)NCc1cccc(F)c1,,CC#N,,CCN(CC)CC,,val
US04070539,C=C(C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl)C(C)C>>CC(C)C1Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1=O,,O,,O=S(=O)(O)O,,val
US20050090483A1,CCOC(=O)Cc1cnc2ccccn12.N>>NC(=O)Cc1cnc2ccccn12,,CO,,,,val
US20050020652A1,CCOC(=O)C(C)(C)Oc1ccc(CCCC2CN(Cc3ccc(C(C)(C)C)cc3)C(=O)N2C)cc1C>>Cc1cc(CCCC2CN(Cc3ccc(C(C)(C)C)cc3)C(=O)N2C)ccc1OC(C)(C)C(=O)O,,CO,,,,val
US20090105124A1,Cc1cc(-c2nc3cnccc3c(=O)n2NCc2ccc(Cl)cc2)ccc1[N+](=O)[O-]>>Cc1cc(-c2nc3cnccc3c(=O)n2NCc2ccc(Cl)cc2)ccc1N,[Pd],CCO,CCOC(C)=O,,,val
US20150175557A1,CC(C)(C)OC(=O)NC1CC(=O)C1(C)C.[Li]C>>CC(C)(C)OC(=O)NC1CC(C)(O)C1(C)C,,C1CCOC1,,,,val
US20030229089A1,BrBr.OCCc1ccc(O)cc1>>OCCc1ccc(O)c(Br)c1,,CC(=O)O,O,,,val
US03976635,N#CC(=NOC(=O)Oc1ccc([N+](=O)[O-])cc1)C(N)=O.O=C(N[C@@H](Cc1ccccc1)C(=O)O)OCc1ccccc1>>O=C(N[C@@H](Cc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1)OCc1ccccc1,,C1CCOC1,,CCN(CC)CC,O,val
US20040013974A1,CS(=O)(=O)Cl.N#CC(=NO)c1cccs1>>CS(=O)(=O)ON=C(C#N)c1cccs1,,C1CCOC1,,CCN(CC)CC,,val
US20060025459A1,COC(=O)c1cc([N+](=O)[O-])c(Cl)c([N+](=O)[O-])c1.NCCCl>>COC(=O)c1cc([N+](=O)[O-])c(NCCCl)c([N+](=O)[O-])c1,,CO,,CCN(CC)CC,Cl,val
US20160235716A1,C#Cc1ccc(CBr)cc1.C[C@H](N)C1CCC1>>C#Cc1ccc(CN[C@@H](C)C2CCC2)cc1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US04400293,BrCc1ccccc1.CCC[C@@H]1CC[C@@H](c2ccc(O)c(N)c2)CC1>>CCC[C@@H]1CC[C@@H](c2ccc(OCc3ccccc3)c(N)c2)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100087427A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2N)C(C)C)ccc1OC.O=S(=O)(Cl)CC1CCOCC1>>COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2NS(=O)(=O)CC2CCOCC2)C(C)C)ccc1OC,,O,,CC#N,CC#N,val
US20140135449A1,[N-]=[N+]=NCC1CCC(CN=[N+]=[N-])O1>>NCC1CCC(CN)O1,[Pd],CO,,,,val
US20020115861A1,Nc1cnc2ccccc2c1NCc1ccccc1.O=C(O)CO>>OCc1nc2cnc3ccccc3c2n1Cc1ccccc1,,Cl,,[NH4+].[OH-],,val
US20150274704A1,CC(C)(C)OC(=O)N1CC2CC(Nc3nc(Cl)ncc3Cl)CC2C1.Cn1cc(N)cn1>>Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(C(=O)OC(C)(C)C)CC4C3)n2)cn1,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20160237095A1,Clc1nccc(Nc2ccc3[nH]ncc3c2)n1.c1ccc2c(c1)CNC2>>c1ccc2c(c1)CN(c1nccc(Nc3ccc4[nH]ncc4c3)n1)C2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120264749A1,CC(C)(C)OC(=O)N1CCC2(CC1)CO2.COc1ccc(CNC(CO)c2ccccc2)cc1>>COc1ccc(CN(CC2(O)CCN(C(=O)OC(C)(C)C)CC2)C(CO)c2ccccc2)cc1,,CCO,,,,val
US20100075948A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.CCc1cc(N)ccc1C(N)=O>>CCNC(=O)c1ccc(NC(=O)C2NC(CC(C)(C)C)C(C#N)(c3ccc(Cl)cc3F)C2c2cccc(Cl)c2F)cc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04616014,CCOC(=O)NCC(=O)NNc1nnc(-c2ccccc2)c(C)n1>>CCOC(=O)NCC(=O)NNC1=NC(C)C(c2ccccc2)=NN1,[Pd],CCO,,Cl,,val
US06008230,CCOC(=O)c1cnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1CC(=O)O>>CCOC(=O)c1cnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1C,,ClCCCl,,,,val
US20160168096A1,CC1(C)OB(c2cc(F)c(OCC3(CC#N)CC3)c(F)c2)OC1(C)C.COCCOC.COc1ccc(-c2cccnc2SC(C)C)cc1>>N#CCC1(COc2c(F)cc(-c3cccnc3SC3CCC3)cc2F)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,N#N,O=C([O-])[O-].[Na+].[Na+],val
US20120202828A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@H]1OC[C@]2(c3cc([N+](=O)[O-])ccc3F)N=C(N)N(C)C(=O)[C@H]12>>C[C@H]1OC[C@]2(c3cc([N+](=O)[O-])ccc3F)N=C(NC(=O)OC(C)(C)C)N(C)C(=O)[C@H]12,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080214495A1,Cn1nc(N2CCC(CN3CCNCC3=O)CC2)ccc1=O.O=S(=O)(Cl)/C=C/c1ccc(Cl)s1>>Cn1nc(N2CCC(CN3CCN(S(=O)(=O)/C=C/c4ccc(Cl)s4)CC3=O)CC2)ccc1=O,,CN(C)C=O,ClCCl,CCN(CC)CC,,val
US20160002175A1,CN1CCN(c2ccc(CN)cc2)CC1.Cc1cccc(-c2cc(Cl)nc(N)n2)c1C>>Cc1cccc(-c2cc(NCc3ccc(N4CCN(C)CC4)cc3)nc(N)n2)c1C,,CCCCO,,CCN(C(C)C)C(C)C,,val
US06100291,CN1CCC[C@@H]1Cc1c[nH]c2ccc(OC3CCCCC3)cc12.O=C(Cl)c1ccccc1>>CN1CCC[C@@H]1Cc1cn(C(=O)c2ccccc2)c2ccc(OC3CCCCC3)cc12,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US03974095,C=COCC.CCO[SiH](OCC)OCC>>CCOCC[Si](OCC)(OCC)OCC,,c1ccccc1,,,,val
US20120277207A1,CC(C)(C)OC(=O)N1CC(OCc2cncs2)C1.Cl>>Cl.c1ncc(COC2CNC2)s1,,CCOCC,,,,val
US04996217,CC(=O)Cl.CN(C)c1ccccc1CSc1nccn1-c1ccc(N)cn1>>CC(=O)Nc1ccc(-n2ccnc2SCc2ccccc2N(C)C)nc1,,ClCCl,,CCN(CC)CC,,val
US06127414,COc1ccc([C@@H](C)NC(=O)[C@H](CCCNC(=NC(=O)OCc2ccccc2)NC(=O)OCc2ccccc2)NC(=O)C(c2ccccc2)c2ccccc2)cc1.Cl>>COc1ccc([C@@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1.Cl,[Pd],CO,,CC(=O)O,,val
US04778817,CC(=O)n1cnc(C)c1.COC(=O)c1ccc2cc(CBr)ccc2c1>>COC(=O)c1ccc2cc(Cc3ncc(C)[nH]3)ccc2c1,,CC#N,,,,val
US20100279868A1,CC12CCC(O1)C(=O)CC2=O.ClP(Cl)(Cl)(Cl)Cl>>CC12CCC(O1)C(Cl)=CC2=O,,ClC(Cl)Cl,,,,val
US20080096882A1,N.O=C(O)[C@@H]1C[C@@H](O)CN1c1nc(N2CCN(c3ccc(Cl)cc3)CC2)nc2c1S(=O)CC2>>NC(=O)[C@@H]1C[C@@H](O)CN1c1nc(N2CCN(c3ccc(Cl)cc3)CC2)nc2c1S(=O)CC2,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20060040918A1,N.O=C(O)c1cnc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cn1>>NC(=O)c1cnc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cn1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US05364871,CC(=O)NCc1nc(-c2csc(N)n2)cs1.Cl>>CC(=O)NCc1nc(-c2csc(N)n2)cs1.Cl,,CO,,CC(C)OC(C)C,,val
US20090176778A1,CC(C)(C)OC(=O)NC1CN(C(=O)c2cn3cc(-c4cn[nH]c4)cc(C(F)(F)F)c3n2)C1.Cl>>Cl.NC1CN(C(=O)c2cn3cc(-c4cn[nH]c4)cc(C(F)(F)F)c3n2)C1,,C1COCCO1,,,,val
US20050004134A1,CCOC(=O)c1nc(-c2ccccc2)c(-c2ccc(=O)n(C(C)C)n2)s1.NCc1cccnc1>>CC(C)n1nc(-c2sc(C(=O)NCc3cccnc3)nc2-c2ccccc2)ccc1=O,,C1COCCO1,,,,val
US20070275900A1,CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N1CCC[C@H]1C(=O)O.COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1>>CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N1CCC[C@H]1C(=O)O.COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1,,CCOC(C)=O,CS(C)=O,CCN(C(C)C)C(C)C,Cl,val
US20080312435A1,Nc1ccccn1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1ccccn1)C(F)(F)F,,ClC(Cl)Cl,,c1ccncc1,,val
US20160068515A1,CC(C)(C)OC(=O)N1CCC(/C(N)=N/O)CC1.CC(C)C(=O)Cl>>CC(C)c1nc(C2CCN(C(=O)OC(C)(C)C)CC2)no1,,Cc1ccccc1,,CCN(CC)CC,,val
US20040254177A1,CC(C)(C)[Si](C)(C)Cl.O=C1c2ccccc2C(=O)N1c1n[nH]c2cc(O)ccc12>>CC(C)(C)[Si](C)(C)Oc1ccc2c(N3C(=O)c4ccccc4C3=O)n[nH]c2c1,,Cl,ClCCl,C1CCC2=NCCCN2CC1,,val
US04594199,C/C=C/C=O.OP(O)CCCCc1ccccc1>>CC(CC=O)P(=O)(O)CCCCc1ccccc1,,ClC(Cl)Cl,,CCN(CC)CC,C[Si](C)(C)Cl,val
US20110311461A1,CCOC(=O)c1cccc(NC(C(=O)O)c2csc3ccccc23)c1.O[C@H]1CN2CCC1CC2>>CCOC(=O)c1cccc(NC(C(=O)O[C@H]2CN3CCC2CC3)c2csc3ccccc23)c1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20060069140A1,CC(=O)c1c(C)nn(-c2ccc(I)cc2)c1O.NNC(=O)c1ccc(O)cc1O>>CC1=NN(c2ccc(I)cc2)C(=O)C1=C(C)NNC(=O)c1ccc(O)cc1O,,CS(C)=O,,,,val
US20090176769A1,CN(C)CCNc1c(F)cccc1C1SC(CC(=O)O)C(=O)N1CCC(C)(C)C.O=C1Nc2ccccc2CCN1C1CCNCC1>>CN(C)CCNc1c(F)cccc1C1S[C@@H](CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N1CCC(C)(C)C,,CN(C)C=O,O,ClCCCl,On1nnc2ccccc21,val
US04128548,COc1ccc2c(c1)C(=CCO)C(C)(C)C(N(C)S(=O)(=O)c1ccc(C)cc1)C2>>COc1ccc2c(c1)C(CCO)C(C)(C)C(N(C)S(=O)(=O)c1ccc(C)cc1)C2,[Pd],CO,,CCN(CC)CC,[H][H],val
US05773530,CCOC(=O)CCN(C)C(=O)OCc1ccccc1.Cl>>CCOC(=O)CCNC.Cl,[Pd],CO,,,,val
US03932663,O=C(Cl)c1ccc(Cl)cc1.c1ccc2c(c1)Cc1ccccc1-2>>O=C(c1ccc(Cl)cc1)c1ccc2c(c1)Cc1ccccc1-2,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130102776A1,CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2O/C(=C\c2c[nH]c4ncccc24)C3=O)CC1.Cl.ClCCl>>Cl.Cl.Cl.O=C1/C(=C/c2c[nH]c3ncccc23)Oc2c1ccc(O)c2CN1CCNCC1,,C1COCCO1,ClCCl,,,val
US20150274747A1,CN(Cc1ccccc1)C1COC2C(OCc3ccccc3)COC21>>CNC1COC2C(O)COC12,[Pd],CCO,,Cl,,val
US04052395,CC(=O)OC(C)=O.Cc1c(Br)cc(-c2ccc(=O)[nH]n2)c(O)c1Br>>CC(=O)Oc1c(-c2ccc(=O)[nH]n2)cc(Br)c(C)c1Br,,c1ccccc1,,,,val
US20090286783A1,CCCS(=O)(=O)Nc1ccc(F)c(C=O)c1F.Cc1ncnc2[nH]ccc12>>CCCS(=O)(=O)Nc1ccc(F)c(C(O)c2c[nH]c3ncnc(C)c23)c1F,,CO,,[K+].[OH-],,val
US05952306,COC(=O)CCCc1ccncc1>>O=C(O)CCCc1ccncc1,,CO,,Cl,[Na+].[OH-],val
US20040121964A1,C#C[C@H]1CC[C@@H](C#N)N1C(=O)CCl.NC12CC3CC(C1)CC(O)(C3)C2>>C#C[C@H]1CC[C@@H](C#N)N1C(=O)CNC12C[C@H]3C[C@H](CC(O)(C3)C1)C2,,CC#N,,,,val
US20150045378A1,COC(=O)c1cc(OC)cc(OCc2ccccc2)c1>>COc1cc(CO)cc(OCc2ccccc2)c1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US04839360,Nc1ccccc1.O=C1CCCC(c2ccc(Cl)cc2)O1>>O=C1CCCC(c2ccc(Cl)cc2)N1c1ccccc1,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070197478A1,CCOC(=O)N(Cc1ccccc1)c1cc(C(F)(F)F)nc(N)c1[N+](=O)[O-]>>CCOC(=O)N(Cc1ccccc1)c1cc(C(F)(F)F)nc(N)c1N,[Pd],CCO,,,,val
US04659365,Cc1cccc(O)c1[N+](=O)[O-].FC(F)(F)CI>>Cc1cccc(OCC(F)(F)F)c1[N+](=O)[O-],,CCOCC,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100216769A1,COC(=O)C1CN1.O=C(Cl)c1ccc(Cl)s1>>COC(=O)C1CN1C(=O)c1ccc(Cl)s1,,ClCCl,,CCN(CC)CC,,val
US06063782,CC=CCn1c(C)c(C)c2cnnc(OCc3ccc(F)cc3)c21.O=C(OO)c1cccc(Cl)c1>>CC=CCn1c(C)c(C)c2c[n+]([O-])nc(OCc3ccc(F)cc3)c21,,ClCCl,,,,val
US04141899,CN=C=S.c1coc(C2NCCc3[nH]cnc32)c1>>CNC(=S)N1CCc2[nH]cnc2C1c1ccco1,,CC#N,,,,val
US20150087646A1,CC(C)(C)C(=O)Cl.NCc1cc(-c2nn(-c3ccc(Cl)cc3)c(=O)[nH]2)c(Cl)cc1F>>CC(C)(C)C(=O)NCc1cc(-c2nn(-c3ccc(Cl)cc3)c(=O)[nH]2)c(Cl)cc1F,,C1CCOC1,,,,val
US04454320,O=C(c1ccccc1)c1cccs1.OCCO>>c1ccc(C2(c3cccs3)OCCO2)cc1,Cc1ccc(S(=O)(=O)O)cc1,,,Cc1ccccc1,,val
US20070105890A1,COC(=O)c1ccc2c3nc(N4CCC[C@@H](NC(=O)OC(C)(C)C)C4)n(Cc4ccccc4Cl)c3c(=O)n(C)c2c1>>Cn1c(=O)c2c(nc(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)n2Cc2ccccc2Cl)c2ccc(C(=O)O)cc21,,CCO,,[Na+].[OH-],,val
US03978127,Cc1ccc(C(O)C(=O)c2ccc(Br)cc2)cc1>>Cc1ccc(C(=O)C(=O)c2ccc(Br)cc2)cc1,,O,,c1ccncc1,,val
US20030236287A1,BrBr.COc1ccc(N)c(OC)c1>>COc1cc(OC)c(Br)cc1N,,ClC(Cl)Cl,,O,O=C([O-])[O-].[K+].[K+],val
US20040087807A1,COC(=O)c1ccc(CO)cc1.NN>>NNC(=O)c1ccc(CO)cc1,,CCO,,O,,val
US20140209866A1,Brc1c2ccccc2c(-c2ccc(-c3cccs3)c3ccccc23)c2ccccc12.CC1(C)C=C(B2OC(C)(C)C(C)(C)O2)C=C2C=c3cc4c5ccccc5c5ccccc5c4cc3=C21>>CC1(C)C=C(c2c3ccccc3c(-c3ccc(-c4cccs4)c4ccccc34)c3ccccc23)C=C2C=c3cc4c5ccccc5c5ccccc5c4cc3=C21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,Cc1ccccc1,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20060167255A1,CCOC(=O)C(C)Br.O=C1CCCc2cc(S(=O)(=O)c3ccccc3)ccc21>>COC(=O)CC1(O)CCCc2cc(S(=O)(=O)c3ccccc3)ccc21,[Zn],O,,c1ccccc1,,val
US20020052344A1,COC(=O)c1ccc(CC(=O)c2ccc(F)cc2)cc1>>O=C(O)c1ccc(CC(=O)c2ccc(F)cc2)cc1,,CCO,,[Na+].[OH-],,val
US04985432,Cc1c(Cl)nc2sc(SCc3ccccc3)nn2c1=O.O=S([O-])OO>>Cc1c(Cl)nc2sc(S(=O)(=O)Cc3ccccc3)nn2c1=O,,CO,,O,,val
US20100273753A1,CC(C)Cn1c(=O)n(C)c(=O)c2cn(Cc3ccc(-c4ccccc4)cc3)nc21.II>>CC(C)Cn1c(=O)n(C)c(=O)c2c(I)n(Cc3ccc(-c4ccccc4)cc3)nc21,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20130281433A1,CC1(C)OB(c2ccc(OCc3ccccc3)nc2)OC1(C)C.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccnc(Cl)c3)sc2c1-c1ccc(Cl)cc1>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccnc(-c4ccc(OCc5ccccc5)nc4)c3)sc2c1-c1ccc(Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20060019985A1,C1CNCCN1.CCOC(=O)c1cc(C2CC2)c2c(C)c(N3CC[C@H](O)C3)c(F)cn2c1=O.O=C(n1ccnc1)n1ccnc1>>CCOC(=O)c1cc(C2CC2)c2c(C)c(N3CCC(OC(=O)N4CCNCC4)C3)c(F)cn2c1=O,,C1CCOC1,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20090093473A1,CS(=O)(=O)O.Cc1nc2c3c(c(C(=O)NC4CC4)cc2n1C)CCC1(Cc2ccccc2C1)N3>>CS(=O)(=O)O.Cc1nc2c3c(c(C(=O)NC4CC4)cc2n1C)CCC1(Cc2ccccc2C1)N3,,CO,,,,val
US20080194535A1,C=CCN(C(=O)OCc1ccccc1)[C@@H]1C[C@@H](NC(=O)C(F)(F)F)c2cc(OC)ccc21>>C=CCN(C(=O)OCc1ccccc1)[C@@H]1C[C@@H](N)c2cc(OC)ccc21,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150119362A1,OCCc1ccc(Nc2nc(-c3cccc(Cl)c3)nc3c2CCC3)cc1>>O=CCc1ccc(Nc2nc(-c3cccc(Cl)c3)nc3c2CCC3)cc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US06716878B1,CON(C)C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C.[Li]C>>CC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C,,C1CCOC1,,,,val
US05821256,CC(C)(C)c1ccc(S(N)(=O)=O)cc1.O=C1NC(=O)c2cc(OC(C(=O)O)c3ccc4c(c3)OCO4)ccc21>>CC(C)(C)c1ccc(S(=O)(=O)NC(=O)C(Oc2ccc3c(c2)C(=O)NC3=O)c2ccc3c(c2)OCO3)cc1,,C1CCOC1,,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US04044141,COC(=O)C1=C(C)NC(C)=C(C(=O)OCc2ccc(Cl)c(Cl)c2)C1c1cccc([N+](=O)[O-])c1>>C/C(N)=C/C(=O)OCc1ccc(Cl)c(Cl)c1,,CCO,,,,val
US20070060601A1,Cc1ccc(N)cc1.O=c1oc(-c2ccccc2Br)nc2ccccc12>>Cc1ccc(-n2c(-c3ccccc3Br)nc3ccccc3c2=O)cc1,,CC(=O)O,O,,,val
US20050020645A1,CCOC(=O)C(=O)Cl.Nc1ccc(Cl)cc1>>CCOC(=O)C(=O)Nc1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US06169091A,O=[N+]([O-])c1ccc(OC(F)(F)c2ccccc2)cc1>>Nc1ccc(OC(F)(F)c2ccccc2)cc1,[Pd],CCOC(C)=O,CO,[H][H],,val
US20100029707A1,COC(=O)CBr.COC(=O)CCc1ncc(O)c(C(=O)OC)c1C(=O)OC>>COC(=O)CCc1ncc(OCC(=O)OC)c(C(=O)OC)c1C(=O)OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US07442702B2,O=C(O)CCc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2ccccc2)c1.O=S(=O)(Cl)c1ccccc1>>COC(=O)CCc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2ccccc2)c1,,CCN(CC)CC,,,,val
US20070270423A1,CC(C)(C)OC(=O)N1CCC(CO)C1.CC(C)N1CCN(C(=O)c2ccc3[nH]ccc3c2)CC1>>CC(C)N1CCN(C(=O)c2ccc3c(ccn3CC3CCN(C(=O)OC(C)(C)C)C3)c2)CC1,,Cc1ccccc1,,CCCCP(=CC#N)(CCCC)CCCC,,val
US20110046170A1,Cc1cc(C(N)=O)nc(Cl)n1>>Cc1cc(C#N)nc(Cl)n1,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US20130184273A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4ncc(-c5ccc(S(C)(=O)=O)cc5)n4cc3-c3ccccc3)cc2)CCC1>>CS(=O)(=O)c1ccc(-c2cnc3nc(-c4ccc(C5(N)CCC5)cc4)c(-c4ccccc4)cn23)cc1,,C1COCCO1,Cl,,,val
US20160152634A1,Clc1nc(Cl)c2c(-c3ccccc3)csc2n1.OC1CC2CCC(C1)N2>>OC1CC2CCC(C1)N2c1nc(Cl)nc2scc(-c3ccccc3)c12,,CCOC(C)=O,O,C1CCOC1,CCN(CC)CC,val
US20050075363A1,CCOC(=O)C(Cc1cc(F)c(Br)cc1F)=C(NC1CC1)SC.CN(C)C=O>>CCOC(=O)c1c(SC)n(C2CC2)c2cc(Br)c(F)cc2c1=O,,[Cl-],[NH4+],[H-].[Na+],,val
US04196205,CC(=O)OCC1=C(C(=O)OC(C)(C)C)N2C(=O)C(N)[C@H]2SC1.O=C(O)C(=NOC1CCCCO1)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>CC(=O)OCC1=C(C(=O)OC(C)(C)C)N2C(=O)C(NC(=O)C(=NOC3CCCCO3)c3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)[C@H]2SC1,,ClC(Cl)Cl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130303515A1,COc1ccc(CN)c(OC)c1.O=S(=O)(Cl)CCCCl>>COc1ccc(CNS(=O)(=O)CCCCl)c(OC)c1,,ClCCl,,Cl,,val
US20100136034A1,CC(=O)NCO.O=C(O)CCS>>CC(=O)NCSCCC(=O)O,,O=C(O)C(F)(F)F,,,,val
US05486541,ON=C1CCc2cc(F)ccc21>>NC1CCc2cc(F)ccc21,[Zn],CC(=O)O,,,,val
US20100137582A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cn1[nH]c(C(F)(F)F)cc1=O>>Cn1[nH]c(C(F)(F)F)cc1=S,,Cc1ccccc1,,,,val
US20150025064A1,CC(=O)c1cccc(C#N)c1.COC(=O)OC>>COC(=O)CC(=O)c1cccc(C#N)c1,,Cc1ccccc1,,[H-].[Na+],,val
US20150274705A1,CCOC(=O)CC1(C[N+](=O)[O-])CCC2(CC1)OCCO2>>O=C1NCCC12CCC1(CC2)OCCO1,[Ni],,,CCO,,val
US20140315902A1,CCOC(=O)c1cnc(Cl)c(C)c1Cl>>Cc1c(Cl)ncc(CO)c1Cl,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US20080255152A1,CC(C)(C)[Si](C)(C)O[C@@H]1CCC[C@H](NCCc2ccc(Oc3ccc(C(N)=O)cn3)cc2)C1>>NC(=O)c1ccc(Oc2ccc(CCN[C@H]3CCC[C@@H](O)C3)cc2)nc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130296329A1,C=Cc1cc(NC(C)(C)C)c([N+](=O)[O-])cc1C(=O)OC.Cl>>C=Cc1cc(N)c([N+](=O)[O-])cc1C(=O)OC.Cl,,CO,,,,val
US20080015199A1,CCI.COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1ccc(O)c(OC)c1>>CCOc1ccc(C(=Nc2ccc(-c3noc(C)n3)cc2)C(=NC(=O)OC)SC)cc1OC,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20120208804A1,C=C(C)CC(O)(CCN(C(=O)OC)C(C)(C)C#Cc1ccc(F)cc1)c1ccccc1>>C=C(C)CC1(c2ccccc2)CCN(C(C)(C)C#Cc2ccc(F)cc2)C(=O)O1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US05047420,CCCBr.COc1cc(C=O)cc(Br)c1O>>CCCOc1c(Br)cc(C=O)cc1OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04829081,CCOC(=O)c1c(C(C)(C)C)oc(-c2ccccc2)c1-c1ccc(F)cc1>>CC(C)(C)c1oc(-c2ccccc2)c(-c2ccc(F)cc2)c1CO,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05547972,CC(C)(CCl)C(=O)Cl.NCc1ccc(Cl)cc1>>CC(C)(CCl)C(=O)NCc1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20090131398A1,CCN(CC)[C@@H]1C[C@H](O)C1>>CCN(CC)[C@@H]1C[C@H](O)C1,,CO,,Cl,[Na+].[OH-],val
US20120122867A1,CCCCCNc1nc(N)nc(C)c1Cc1ccc(OC)cc1>>CCCCCNc1nc(N)nc(C)c1Cc1ccc(O)cc1,,ClCCl,,BrB(Br)Br,O,val
US20160237075A1,CC(C)(C)OC(=O)N1CC(n2cc(C(=O)O)c(-c3ccc(Oc4ccccc4)cc3)n2)C1.[NH4+]>>CC(C)(C)OC(=O)N1CC(n2cc(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)n2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030176698A1,CCCn1c(=O)nc(SC)c2[nH]c(C3CCCC3)nc21.N[C@H](CO)Cc1ccncc1>>CCCn1c(=O)nc(N[C@H](CO)Cc2ccncc2)c2[nH]c(C3CCCC3)nc21,,c1ccncc1,,,,val
US20070167443A1,CON(C)C(=O)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O.Cc1ncc(I)n1C>>Cc1ncc(C(=O)c2cn(Cc3cccc(Br)n3)c3ccccc3c2=O)n1C,,ClCCl,,CC(C)[Mg]Cl,,val
US20030032835A1,O=S(=O)([O-])C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>O=S(=O)(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,,CO,,Cl,,val
US20060052360A1,BrCc1ccccc1.CC(C)C(c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1)N1CCNCCC1=O>>CC(C)C(c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1)N1CCN(Cc2ccccc2)CCC1=O,,ClCCl,,CCN(CC)CC,,val
US05006159,CCC(=O)C1=C(O)CC(c2ccc(SC)cc2)CC1=O.OO>>CCC(=O)C1=C(O)CC(c2ccc(S(C)=O)cc2)CC1=O,,ClCCl,,CC(=O)O,,val
US20110245257A1,COC(=O)c1cccc([N+](=O)[O-])c1NC1CC1>>COC(=O)c1cccc(N)c1NC1CC1,[Pd],CO,,,,val
US04933355,OCc1csc(NC2CCCCC2)n1>>O=Cc1csc(NC2CCCCC2)n1,,CS(C)=O,,CCN(CC)CC,,val
US20110224155A1,CC(=O)N(C)C.CC(C)Nc1cccc(N)c1C#N.NS(=O)(=O)Cl>>CC(C)Nc1cccc(N)c1C#N.NS(N)(=O)=O,,CC(=O)N(C)C,O,,,val
US20100261698A1,CN(C)C=O.Cn1c(-c2cnccc2Cl)cc2ccccc21.O=C=NS(=O)(=O)Cl>>N#Cc1c(-c2cnccc2Cl)[nH]c2ccccc12.[NH4+].[OH-],,CN(C)C=O,,ClCCl,,val
US20140221335A1,CS(=O)(=O)Cl.CS(=O)(=O)c1cc(C#N)ccc1C1NC(=O)N(c2ccnc(C(F)(F)F)c2)C2=C1C(=O)CC2>>CS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2ccnc(C(F)(F)F)c2)C(=O)N1S(C)(=O)=O,,C1CCOC1,,O,[H-].[Na+],val
US20090137609A1,CCC(CC)(c1ccc(CCC2(O)CCCCC2)c(C)c1)c1ccc(-c2ccc(CC(=O)OC)cc2)c(C)c1>>CCC(CC)(c1ccc(CCC2(O)CCCCC2)c(C)c1)c1ccc(-c2ccc(CC(=O)O)cc2)c(C)c1,,C1CCOC1,CO,[Na+].[OH-],[Cl-].[NH4+],val
US20090118305A1,Nc1cccc(F)c1O.Nc1ncc(Br)cc1C(=O)O>>Nc1ncc(Br)cc1-c1nc2cccc(F)c2o1,,O,,[Na+].[OH-],,val
US05308854,CCc1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCc1cc(CCc2nc3ccccc3o2)c(=S)[nH]c1C,,Cc1ccccc1,,,,val
US20030045558A1,CCOC(=O)C(C)(C)Oc1ccc(O)cc1.Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccc(Br)cc3)oc2C)cc1>>CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccc(Br)cc3)oc2C)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130172550A1,N#Cc1cccc(Nc2ccc3c(c2N)CCC3)c1.O=C(Cl)CC(=O)Cl>>N#Cc1cccc(N2C(=O)CC(=O)Nc3c2ccc2c3CCC2)c1,,CO,,C1CCOC1,,val
US20160038504A1,C[C@H]1COCCN1.Clc1cc(Cl)c(Cl)nn1>>C[C@H]1COCCN1c1cc(Cl)nnc1Cl,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,O,val
US20100093757A1,CC(C)[Si](OC[C@@H](C)OC[C@H](Oc1ncnc2c1cnn2-c1ccccc1Cl)C(=O)Nc1ccccn1)(C(C)C)C(C)C>>C[C@H](CO)OC[C@H](Oc1ncnc2c1cnn2-c1ccccc1Cl)C(=O)Nc1ccccn1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05231102,COC(=O)Cc1ccc(CC#CO)cc1.ClC(Cl)(Cl)Cl>>COC(=O)Cc1ccc(CC#CCl)cc1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120232056A1,CCCN(CCC)c1nc2cc(C(=O)OC)ccc2nc1-c1ccc(F)cc1>>CCCN(CCC)c1nc2cc(C(=O)O)ccc2nc1-c1ccc(F)cc1,,CO,O,[Na+].[OH-],,val
US04937243,CC(=O)OC(C)=O.CNC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)C(CC(C)C)C(S)CC(=O)OCc1ccccc1>>CNC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)C(CC(C)C)C(CC(=O)OCc1ccccc1)SC(C)=O,,ClC(Cl)Cl,,CN1CCOCC1,,val
US20100160682A1,NC(=O)C1=CCCc2cc(Sc3ccccc3)cc(F)c21>>NC(=O)[C@@H]1CCCc2cc(Sc3ccccc3)cc(F)c21,,CO,,,,val
US20130090342A1,N#CBr.Nc1ccccc1Nc1ccc(Br)cc1>>Nc1nc2ccccc2n1-c1ccc(Br)cc1,,CC#N,O,,,val
US20100184789A1,O=[N+]([O-])c1cccc(CS(=O)(=O)CCO)c1>>Nc1cccc(CS(=O)(=O)CCO)c1,[Ni],CO,,[H][H],,val
US20150353499A1,COC(=O)c1ccc(C)c(Br)c1.OB(O)c1ccccc1>>COC(=O)c1ccc(-c2ccccc2)c(C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20110294806A1,CC(OS(C)(=O)=O)c1c(Cl)ccc(F)c1Cl.CCOC(=O)C(C(=O)OCC)c1ncc(Br)cc1[N+](=O)[O-]>>CC(On1ccc2ncc(Br)cc21)c1c(Cl)ccc(F)c1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130274242A1,CCN(CC)CC.Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(Cl)c(C)n4C)n2)cc1C=O>>Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(Cl)c(C)n4C)n2)cc1CN1CC(O)C1,,ClCCl,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20160083401A1,N#CC(c1ccc(F)c(Br)c1)c1ccc(OC(F)F)nn1.OO>>O=C(c1ccc(F)c(Br)c1)c1ccc(OC(F)F)nn1,,CC#N,,O,CC(C)(C)[O-].[K+],val
US20090186886A1,CC(=O)c1ccc2c(c1)CCO2.NO>>CC(=NO)c1ccc2c(c1)CCO2,,CO,,Cl,c1ccncc1,val
US20050159469A1,O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O.O=C1OCC[C@H]1O>>O=C(O[C@@H]1CCOC1=O)ON1C(=O)CCC1=O,,CC#N,,CCN(CC)CC,,val
US20060194783A1,CC(C)(C)OC(=O)N[C@@H]1CCCCN(CC2CC2)C1=O.O=C(Cl)N1CCC(N2Cc3ccccc3NC2=O)CC1>>O=C(N[C@@H]1CCCCN(CC2CC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1,,ClCCCl,ClCCl,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US05108485,CI.COC(=O)c1ccc2[nH]nnc2c1C(=O)OC>>COC(=O)c1ccc2c(nnn2C)c1C(=O)OC,,CN(C)C=O,,[H-].[Na+],,val
US20150291598A1,CNc1ccc(F)cc1.O=C(O)c1cn2c(Br)cnc2cn1>>CN(C(=O)c1cn2c(Br)cnc2cn1)c1ccc(F)cc1,,Cc1ccccc1,ClCCl,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20100152441A1,COc1ccc2c(c1)N(CCN1CCC(NCc3ccc4c(n3)NC(=O)CO4)CC1)C(=O)CO2>>O=C1COc2ccc(CNC3CCN(CCN4C(=O)COc5ccc(O)cc54)CC3)nc2N1,,ClCCl,,BrB(Br)Br,,val
US20160052884A1,CC(C)(C)OC(=O)Nc1ccc(-c2noc(=S)[nH]2)cc1>>Nc1ccc(-c2noc(=S)[nH]2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04010177,NNC(=O)CO.S=C1CN=C(c2ccccc2)c2cc(Cl)ccc2N1>>OCc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2,,CCCCO,,,,val
US20040162285A1,Nn1c(=O)c(C2=NS(=O)(=O)c3cc(OCc4ccccc4)ccc3N2)c(O)c2sccc21.O=C1CCCCC1>>O=c1c(C2=NS(=O)(=O)c3cc(OCc4ccccc4)ccc3N2)c(O)c2sccc2n1N=C1CCCCC1,,CC(=O)N(C)C,,,,val
US20120328569A1,N#Cc1cccc(O)c1.O=N[O-]>>N#Cc1cccc(O)c1[N+](=O)[O-],,ClCCl,,O=S(=O)(O)O,,val
US20040171570A1,CC(=O)OC(C)=O.CC(C)[Si]1(C(C)C)OCC2OC(n3ccc(=O)[nH]c3=O)C(O)C2O[Si](C(C)C)(C(C)C)O1>>CC(=O)OC1C2O[Si](C(C)C)(C(C)C)O[Si](C(C)C)(C(C)C)OCC2OC1n1ccc(=O)[nH]c1=O,,c1ccncc1,,CCN(CC)CC,CO,val
US20070225280A1,CCOC(=O)C=CN(C)C.O=C(O)c1cc(Cl)on1>>CCOC(=O)C(=CN(C)C)C(=O)c1cc(Cl)on1,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US05593969,CCCCCCCCCCC[C@H](CCO[Si](C)(C)C(C)(C)C)OCc1ccccc1>>CCCCCCCCCCC[C@H](CCO)OCc1ccccc1,,CC#N,,O=C([O-])O.[Na+],,val
US20130190312A1,COc1ccc(Oc2cc(C)c(C(=O)CBr)c(C)c2)nc1.NC(N)=S>>COc1ccc(Oc2cc(C)c(-c3csc(N)n3)c(C)c2)nc1,,CCO,,,,val
US20150183768A1,CCOC(CBr)OCC.Fc1ccc(-c2cc[nH]n2)nc1>>CCOC(Cn1ccc(-c2ccc(F)cn2)n1)OCC,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04493833,COSCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nncs3)CS[C@H]12)c1csc(NC=O)n1>>CSCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nncs3)CS[C@H]12)c1csc(N)n1,,C1CCOC1,,CO,Cl,val
US20150329506A1,C=Cc1c(C)noc1C.NC(N)=S.O=Cc1cc(-c2cncnc2)c(F)cc1F>>Cc1noc(C)c1C1CC(c2cc(-c3cncnc3)c(F)cc2F)N=C(N)S1,,CCOC(C)=O,CN(C)C=O,C[Si](C)(C)Cl,,val
US20100183564A1,CC(C)n1cnc2c(NCCc3ccc(O)cc3)nc(Cl)nc21.Cc1ncc[nH]1>>Cc1nccn1-c1nc(NCCc2ccc(O)cc2)c2ncn(C(C)C)c2n1,,CN1CCCC1=O,,,,val
US20020042525A1,Cc1cc2c(c(=O)o1)C(=O)CC(C(C)C)O2>>Cc1cc(O)c(C(=O)C=CC(C)C)c(=O)o1,,CC(C)O,,O=C([O-])[O-].[K+].[K+],,val
US20080167287A1,CN.O=C(O)c1ccc(-c2cnc3ncc(C4(c5ccc6ncccc6c5)CC4)n3c2)c(F)c1>>CNC(=O)c1ccc(-c2cnc3ncc(C4(c5ccc6ncccc6c5)CC4)n3c2)c(F)c1,,CN(C)C=O,CO,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20150152047A1,CC(C)(C)OC(=O)NCCNC(=O)[C@H]1CCCN(C(=O)OCc2ccccc2)C1>>CC(C)(C)OC(=O)NCCNC(=O)[C@H]1CCCNC1,[Pd],CO,,,,val
US20090044857A1,C1CCOC1.CCCCI.CS(C)=O.Ic1ccc2c(c1)Cc1ccccc1-2>>CCCCC1(CCCC)c2ccccc2-c2ccc(I)cc21,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US05268389,CC1=C(C(=O)O)SCCO1.CCCOC(=O)c1cc(N)ccc1Cl>>CCCOC(=O)c1cc(NC(=O)C2=C(C)OCCS2)ccc1Cl,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20110020460A1,CC(C)(C)[Si](C)(C)Cl.OCCSc1ccc(O)c(F)c1>>CC(C)(C)[Si](C)(C)OCCSc1ccc(O)c(F)c1,,CN(C)C=O,,c1c[nH]cn1,,val
US20060142321A1,CC(=O)OC(C)=O.NCCCN1CCc2cccc3c2C1CC3>>CC(=O)NCCCN1CCc2cccc3c2C1CC3,,ClCCl,,O=C([O-])O.[Na+],,val
US20160016944A1,CNC(=N\O)/C(=N\OCc1cccc(NC(=O)OC(C)(C)C)n1)c1ccccc1.S=C(Cl)Cl>>Cn1c(/C(=N\OCc2cccc(NC(=O)OC(C)(C)C)n2)c2ccccc2)noc1=S,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,O,val
US20140343056A1,CCOC(=O)C(=O)CC(=O)C1CC1.Cc1cc(N)n(C2CC2)n1>>CCOC(=O)c1cc(C2CC2)nc2c1c(C)nn2C1CC1,,CC(=O)O,,,,val
US20130231328A1,CC(=O)Cl.NCCc1cc2c(O)ncnc2s1>>CC(=O)NCCc1cc2c(O)ncnc2s1,,ClCCl,,,,val
US20110196153A1,Cn1ncnc1Cc1n[nH]c(=O)c2cc(F)cc(/N=C/c3ccc(F)cc3)c12>>Cn1ncnc1C1c2n[nH]c(=O)c3cc(F)cc(c23)NC1c1ccc(F)cc1,,C1CCOC1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120202853A1,CCc1nn(-c2ccc(OC)cc2)c(-c2occc2C)c1C#N>>CCc1nn(-c2ccc(O)cc2)c(-c2occc2C)c1C#N,,ClCCl,,BrB(Br)Br,,val
US06143764,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.O=C=Nc1ccc(C(F)(F)F)cc1>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(C(F)(F)F)cc4)cc3)c2cc1OC,,Cc1ccccc1,,,,val
US20130178486A1,N#CCC(=O)C1CC(F)(F)C1.NN>>Nc1cc(C2CC(F)(F)C2)[nH]n1,,CCO,,O,,val
US05153227,O=C(O)c1ccc(S(=O)(=O)C[N+](=O)[O-])cc1>>O=[N+]([O-])CS(=O)(=O)c1ccc(CO)cc1,,C1CCOC1,,Cl,,val
US20070129416A1,CCOc1cc(C(C)(C)C#N)ccc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1.O=C(Cl)Cl>>CCOc1cc(C(C)(C)C#N)ccc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1C(=O)Cl,,CCN(CC)CC,,,,val
US20120197014A1,CCCCCCCCBr.O=C(O)Cc1c[nH]c2ccc(Br)cc12>>CCCCCCCCn1cc(CC(=O)O)c2cc(Br)ccc21,,C1CCOC1,,CCOCC,[H-].[Na+],val
US20140134110A1,CC(NCCCOCC(COCCCNC(C)=C1C(=O)CC(C)(C)CC1=O)(COCCCNC(C)=C1C(=O)CC(C)(C)CC1=O)NC(=O)OC(C)(C)C)=C1C(=O)CC(C)(C)CC1=O>>CC(NCCCOCC(N)(COCCCNC(C)=C1C(=O)CC(C)(C)CC1=O)COCCCNC(C)=C1C(=O)CC(C)(C)CC1=O)=C1C(=O)CC(C)(C)CC1=O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20040097431A1,C/C(=C\Cc1c(C)c(O)c(C)c(C)c1O)CCC[C@H](C)CCC[C@H](C)CCCC(C)C.CC(=O)O.CC(=O)O.N#Cc1ccccc1.O=S(=O)(O)O>>CC(=O)O.CC(=O)O.Cc1c(C)c(O)c(CCC(C)(CCCC(C)CCCC(C)CCCC(C)C)NC(=O)c2ccccc2)c(C)c1O,,CC(=O)O,,,,val
US20150376164A1,O=C(Cl)C(=O)Cl.O=C(O)CC1CCN(C(=O)OCc2ccccc2)CC1>>O=C(Cl)CC1CCN(C(=O)OCc2ccccc2)CC1,,ClCCl,,CN(C)C=O,,val
US20040024010A1,CC(C(=O)O)c1c(C=O)[nH]c2c1CCCC2.CC(C)NS(=O)(=O)c1ccc2c(c1)CC(=O)N2>>CC(C)NS(=O)(=O)c1ccc2c(c1)C(=Cc1[nH]c3c(c1CCC(=O)O)CCCC3)C(=O)N2,,CCO,,C1CCNCC1,CC(=O)O,val
US20030087957A1,CC(C)(C)NO.CCOc1ccccc1C=O>>CCOc1ccccc1C=[N+]([O-])C(C)(C)C,,ClC(Cl)Cl,,,,val
US03946049,COc1ccc(-c2ccc(C=O)o2)cc1.NO>>COc1ccc(-c2ccc(C=NO)o2)cc1,,O,,Cl,,val
US20080161295A1,BrCC[C@H]1CO1.O=S1(=O)NCc2cc(F)ccc2N1c1ccccc1F>>O=S1(=O)N(CC[C@H]2CO2)Cc2cc(F)ccc2N1c1ccccc1F,,CC(C)=O,CCOCC,O=C([O-])[O-].[K+].[K+],,val
US20050054657A1,O=c1c2cc([N+](=O)[O-])ccc2sc2c(Br)cccc12>>O=[N+]([O-])c1ccc2c(c1)Cc1cccc(Br)c1S2,,C1CCOC1,,B,,val
US20160200681A1,CNC1CCc2c1cn(S(=O)(=O)c1cccc(F)c1)c2-c1ccc(F)cc1F.Cc1oc(=O)oc1COC(=O)Oc1ccc([N+](=O)[O-])cc1>>Cc1oc(=O)oc1COC(=O)N(C)C1CCc2c1cn(S(=O)(=O)c1cccc(F)c1)c2-c1ccc(F)cc1F,,CN(C)C=O,,O,,val
US04176116,CC(C)(C)C(=O)Cl.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N>>CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)C(C)(C)C,,c1ccncc1,,Br,,val
US20120196869A1,CN1CCn2c(C(=O)C(C)(C)C)ccc2C12CCN(C(=O)OC(C)(C)C)CC2.Cl.ClCCl>>CN1CCn2c(C(=O)C(C)(C)C)ccc2C12CCNCC2.Cl.Cl,,ClCCl,,,,val
US20090227588A1,CCOC(C)([O-])[O-].O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CCOC(=CC(=O)C(F)(F)F)OCC,,ClC(Cl)Cl,,,,val
US20080004302A1,COc1cc(CO)cc(OC)n1>>COc1cc(C=O)cc(OC)n1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20100048581A1,COc1ccc(C=O)cc1.C[N+](=O)[O-]>>COc1ccc(/C=C/[N+](=O)[O-])cc1,,CO,,[Na+].[OH-],,val
US20150175530A1,CC(C)(C)[Si](C)(C)OC/C=C\CO[Si](C)(C)C(C)(C)C.O=[O+][O-]>>CC(C)(C)[Si](C)(C)OCC=O,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100152190A1,CC1(C)O[C@@H](CCN=[N+]=[N-])C(C)(C)O1>>CC1(C)O[C@@H](CCN)C(C)(C)O1,O=[Pt]=O,CCOC(C)=O,,,,val
US20060252837A1,Nc1ncc(Cl)cn1.O=C(Cl)C(Cl)Cl>>O=C(Nc1ncc(Cl)cn1)C(Cl)Cl,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20150284395A1,CCOC(=O)CC(=O)c1ccc2cnn(CC)c2c1.N#Cc1cn[nH]c1N>>CCn1ncc2ccc(-c3cc(=O)n4ncc(C#N)c4[nH]3)cc21,Cc1ccc(S(=O)(=O)O)cc1,CCCCO,,,,val
US20110319378A1,C=CCBr.C[Si](C)(C)CCOCN1C(=O)[C@@]2(c3ccc(Cl)cc31)[C@@H](c1cccc(Cl)c1)CCC(=O)N2CC1CC1>>C=CC[C@H]1C[C@H](c2cccc(Cl)c2)[C@]2(C(=O)N(COCC[Si](C)(C)C)c3cc(Cl)ccc32)N(CC2CC2)C1=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US05086049,CCOC(=O)c1c2n(c3cc(N4CCNCC4)c(F)cc3c1=O)C(c1ccccc1)S2.Cc1oc(=O)oc1CBr>>CCOC(=O)c1c2n(c3cc(N4CCN(Cc5oc(=O)oc5C)CC4)c(F)cc3c1=O)C(c1ccccc1)S2,,CN(C)C=O,,O=C([O-])O.[K+],,val
US20080132542A1,CCOC(=O)Cn1nnc(-c2nnc(N3CCC(Oc4ccccc4C(F)(F)F)CC3)s2)n1>>O=C(O)Cn1nnc(-c2nnc(N3CCC(Oc4ccccc4C(F)(F)F)CC3)s2)n1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20150158854A1,O=C(O)c1ccccc1[N+](=O)[O-]>>Nc1ccccc1C(=O)O,[Pd],CO,,,,val
US20050096389A1,CCOC(=O)C(CC(C)C)(CC(C)C)C(=O)OCC>>CC(C)CC(CO)(CO)CC(C)C,,CCOCC,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05747486,CCOC(=O)CC(=O)CCl.COc1ccc(C(=O)c2c(N)sc(C)c2C)cc1OC>>CCOC(=O)c1c(CCl)nc2sc(C)c(C)c2c1-c1ccc(OC)c(OC)c1,,CC(=O)O,,O=S(=O)(O)O,,val
US20090312369A1,CC(C)(C)OC(=O)N1CCC[C@@H]([C@@H](OCCOS(C)(=O)=O)c2cccc(F)c2)C1.[N-]=[N+]=[N-]>>CC(C)(C)OC(=O)N1CCC[C@@H]([C@@H](OCCN=[N+]=[N-])c2cccc(F)c2)C1,,CCOC(C)=O,,CN(C)C=O,,val
US20080194587A1,CCOc1cc2c(cc1OC)C(c1ccc(OC)nc1OC)=N[C@@H]1CC[C@@H](O)C[C@H]21.O=S(=O)(O)CCS(=O)(=O)O>>CCOc1cc2c(cc1OC)C(c1ccc(OC)nc1OC)=N[C@@H]1CC[C@@H](O)C[C@H]21.O=S(=O)(O)CCS(=O)(=O)O,,C1CCOC1,,,,val
US20060217380A1,CN(C(=O)OC(C)(C)C)[C@H]1CCCN(c2ccc(C(F)(F)F)cc2[N+](=O)[O-])C1>>CN(C(=O)OC(C)(C)C)[C@H]1CCCN(c2ccc(C(F)(F)F)cc2N)C1,[Pd],CO,,,,val
US05700921,CN(CCCNc1ccc(N=[N+]=[N-])cc1[N+](=O)[O-])CCCNN1C(=O)CC(NC(=O)CSSCCO)C1=O.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CN(CCCNc1ccc(N=[N+]=[N-])cc1[N+](=O)[O-])CCCNN1C(=O)CC(NC(=O)CSSCCO)C1=O.O=C(O)CC(O)(CC(=O)O)C(=O)O,,CO,,,,val
US04529737,O=C(O)Cc1ccc(-c2ccccc2)cc1.O=C1OC(Br)c2ccccc21>>O=C(Cc1ccc(-c2ccccc2)cc1)OC1OC(=O)c2ccccc21,,ClC(Cl)Cl,,CCN(CC)CC,,val
US08940918B2,CN(C)c1ccc(/C=C(\C#N)C(=O)OCC2COC(C)(C)O2)cc1>>CN(C)c1ccc(/C=C(\C#N)C(=O)OCC(O)CO)cc1,,C1CCOC1,CO,CCN(CC)CC,,val
US20120329785A1,CN1CCN(C(=O)c2ccc(N)cc2)CC1.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1>>COc1ccc2nc(Nc3ccc(CN4CCN(C)CC4)cc3)c3n[nH]cc3c2c1,C1COCCO1,CO,O,Cl,[Na+].[OH-],val
US04804661,Clc1ccc(CCN2CCNCC2)cc1.O=C(Cl)c1ccccc1C(F)(F)F>>Cl.O=C(c1ccccc1C(F)(F)F)N1CCN(CCc2ccc(Cl)cc2)CC1,,ClCCl,,,,val
US20100160302A1,CC(C)(C)OC(=O)NC12CC3CC1CC(CN1CCSCC1)(C3)C2.Cl>>Cl.NC12CC3CC1CC(CN1CCSCC1)(C3)C2,,CCOC(C)=O,,,,val
US04868202,FC(F)(F)C(Cl)=Cc1cccc(Cl)c1Cl>>FC(F)(F)C#Cc1cccc(Cl)c1Cl,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20080058320A1,COC(=O)C(C)(C)[C@H]1CCCN(C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N1CCC[C@H](C(C)(C)C(=O)O)C1,,CO,,[Na+].[OH-],,val
US20100022484A1,CC(N)=CC(=O)c1ccc(C)cc1.CCOC(=O)CC(C)=O.Cc1cc(=O)c2cccc(C=O)c2o1>>CCOC(=O)C1=C(C)NC(C)=C(C(=O)c2ccc(C)cc2)C1c1cccc2c(=O)cc(C)oc12,,CC(C)O,,CC(=O)O,,val
US20080280337A1,CC(C)=CCCC(C)=CC=O>>CC(C)=CCCC(C)CC=O,,Cc1ccccc1,,CC(C)O,,val
US04367237,CCCCCCCCCC=[N+]=[N-].CCCCC[C@H](O)/C=C/[C@@H]1[C@H]2CC(CCCCC(=O)O)S[C@H]2C[C@H]1O>>CCCCCCCCCCOC(=O)CCCCC1C[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)CCCCC)S1,,ClCCl,,CO,,val
US20140288067A1,CN.Cc1c(N[C@@H]2CCOC2)nc(-c2cccc(OCC3CO3)c2)nc1N1CCOCC1>>CNCC(O)COc1cccc(-c2nc(N[C@@H]3CCOC3)c(C)c(N3CCOCC3)n2)c1,,CO,,,,val
US04273782,CCOC(=O)Cn1cc(Cc2ncc[nH]2)c2ccccc21>>O=C(O)Cn1cc(Cc2ncc[nH]2)c2ccccc21,,CCO,O,[Na+].[OH-],,val
US20100273782A1,N#Cc1ccc(Oc2cc(Cl)ccc2Cl)c([N+](=O)[O-])c1>>N#Cc1ccc(Oc2cc(Cl)ccc2Cl)c(N)c1,,C1CCOC1,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20090111860A1,CCC1C(=O)ON=C1[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(Cl)cc1.C[Si](C)(C)CNN>>CCc1c([C@@H](Cc2ccccc2)NS(=O)(=O)c2ccc(Cl)cc2)noc1OC,,C1CCOC1,CCOCC,O,,val
US20130158075A1,COC(=O)C1CCC(C(=O)NCC(=O)c2ccc([N+](=O)[O-])cc2)CC1>>COC(=O)C1CCC(c2ncc(-c3ccc([N+](=O)[O-])cc3)o2)CC1,,CC#N,,O=P(Cl)(Cl)Cl,O=C([O-])O.[Na+],val
US20030073846A1,COCOc1ccc(C[C@H](N)COC)cc1.c1ccc(OC[C@@H]2CO2)cc1>>COCOc1ccc(C[C@@H](COC)NC[C@H](O)COc2ccccc2)cc1,,CCO,,,,val
US05616594,CN(N=C(Cl)c1c(F)cccc1Cl)S(C)(=O)=O.Clc1ccccc1.N#Cc1ccc(-c2ccc(OC(F)(F)F)cc2)cc1>>Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1Cl,Cl[Fe](Cl)Cl,,,ClC(Cl)Cl,,val
US20030095958A1,CC(C)(C)OC(=O)N1CCCN(c2ccc(C(F)(F)F)cc2N)CC1.O=C(Cl)c1cccc2ccccc12>>CC(C)(C)OC(=O)N1CCCN(c2ccc(C(F)(F)F)cc2NC(=O)c2cccc3ccccc23)CC1,,ClCCl,,,,val
US20080070866A1,CC(C)(C)OC(=O)N1C(C)(C)OC[C@]1(C)c1nnc(-c2ccc(OCCCO)c(C(F)(F)F)c2)s1.CCCCBr>>CCCCOCCCOc1ccc(-c2nnc([C@@]3(C)COC(C)(C)N3C(=O)OC(C)(C)C)s2)cc1C(F)(F)F,,C1CCOC1,CCOC(C)=O,CC(C)(C)[O-].[K+],,val
US20130225620A1,Clc1nccc(Nc2cc(C3CC3)n[nH]2)n1.NCc1cc2nc[nH]c2cc1Cl>>Clc1cc2[nH]cnc2cc1CNc1nccc(Nc2cc(C3CC3)[nH]n2)n1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20050222414A1,CCOC(=O)c1ccc(N2CCNCC2)cc1.Cc1ccc(N=C=O)cc1>>CCOC(=O)c1ccc(N2CCN(C(=O)Nc3ccc(C)cc3)CC2)cc1,,ClCCl,,CCN(CC)CC,,val
US07608629B2,CN1CCC(Cl)CC1.Nc1cccc(S)c1>>CN1CCC(Sc2cccc(N)c2)CC1,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20040063985A1,O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=S(=O)(O)C(F)(F)F.SCCCS>>FC(F)(F)[C+]1SCCCS1.O=S(=O)([O-])C(F)(F)F,,CCOCC,,CC(=O)OC(C)=O,,val
US20130317065A1,Cc1ccc(C(C)O)cc1NC(=O)OC(C)(C)C>>CCc1ccc(C)c(NC(=O)OC(C)(C)C)c1,[Pd],CCOC(C)=O,,,,val
US20080275027A1,O=C(OCc1ccccc1)N1CCN(c2ccc(OC3CCNCC3)cc2)C(=O)C1.O=C1CCCC1>>O=C(OCc1ccccc1)N1CCN(c2ccc(OC3CCN(C4CCCC4)CC3)cc2)C(=O)C1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130123234A1,CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCC(NC(=O)OC(C)(C)C)CC3)nc2)cc(N(CC)C2CCOCC2)c1C>>CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCC(N)CC3)nc2)cc(N(CC)C2CCOCC2)c1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110212998A1,COC(=O)c1cc(C)nc(CO)c1>>Cc1cc(C(=O)O)cc(CO)n1,,Cl,,,,val
US20100168103A1,O=C(O)CC(c1ccccc1)c1ccccc1.c1ccc(C2(CN3CCCCC3)CCNCC2)cc1>>O=C(CC(c1ccccc1)c1ccccc1)N1CCC(CN2CCCCC2)(c2ccccc2)CC1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20100256097A1,C#Cc1ccc(Cl)nc1C.CC(C)=O>>Cc1nc(Cl)ccc1C#CC(C)(C)O,,COC(C)(C)C,,[Li]CCCC,,val
US20080312336A1,O=C1CCCC(S(=O)(=O)c2ccccc2)C1.OCCO>>O=S(=O)(c1ccccc1)C1CCCC2(C1)OCCO2,,c1ccccc1,,O=C([O-])O.[Na+],,val
US20080009530A1,CCOC(=O)CCc1cc(OCc2ccccc2)nn1Cc1ccc(Cl)cc1Cl>>O=C(O)CCc1cc(OCc2ccccc2)nn1Cc1ccc(Cl)cc1Cl,,CCO,,C1CCOC1,[Na+].[OH-],val
US20070078121A1,CC(C)(C)OC(=O)N1CCN(c2ccc3cc(-n4nc(C(C)(C)C)cc4C(=O)O)ccc3n2)CC1.Nc1cccc(Cl)c1Cl.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N1CCN(c2ccc3cc(-n4nc(C(C)(C)C)cc4NC(=O)Nc4cccc(Cl)c4Cl)ccc3n2)CC1,,Cc1ccccc1,,CCN(CC)CC,,val
US20080153813A1,CCOCc1cnc2ccc(Cl)nn12.Cl.NCc1ccccn1>>CCOCc1cnc2ccc(NCc3ccccn3)nn12.Cl,,CCOCC,,,,val
US20070244125A1,C1CCC(N2CCNCC2)C1.CCOC(=O)c1cc2cc(C(=O)O)ccc2[nH]1>>CCOC(=O)c1cc2cc(C(=O)N3CCN(C4CCCC4)CC3)ccc2[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120142717A1,COC(=O)C(C=O)Cc1cnc(OC)nc1.N=C(N)OCCc1ccc(Oc2ccc(C(F)(F)F)nc2)cc1>>COc1ncc(Cc2c[nH]c(OCCc3ccc(Oc4ccc(C(F)(F)F)nc4)cc3)nc2=O)cn1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US05153352,CC(C)(C)[Si](C)(C)OCCC1C(O)CC1CO[Si](C)(C)C(C)(C)C.CS(=O)(=O)Cl>>CC(C)(C)[Si](C)(C)OCCC1C(CO[Si](C)(C)C(C)(C)C)CC1OS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20070293533A1,C#CC(C)(C)OC1CCCCO1.CCOC(=O)Cl>>CCOC(=O)C#CC(C)(C)OC1CCCCO1,,C1CCOC1,,[Li]CCCC,,val
US20060235067A1,C1CCNC1.Cc1cc(C(C)(C)C(=O)O)sc1Br>>Cc1cc(C(C)(C)C(=O)N2CCCC2)sc1Br,,CCOC(C)=O,ClCCl,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20030220368A1,COc1ncccc1CN1CCC(CC(=O)c2cccnc2Cl)CC1>>O=C(CC1CCN(Cc2ccc[nH]c2=O)CC1)c1cccnc1Cl,,CC#N,,CCOC(C)=O,Cl,val
US20030087907A1,CC(=O)c1sc(N)nc1C.COc1cc2nccc(Oc3ccc(N)c(F)c3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4nc(C)c(C(C)=O)s4)c(F)c3)c2cc1OC,,ClC(Cl)Cl,O,CCN(CC)CC,,val
US20070099956A1,Cc1cccc(C)c1/C=C/C1CCN(C(=O)CCl)CC1.c1c[nH]cn1>>Cc1cccc(C)c1/C=C/C1CCN(C(=O)Cn2ccnc2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20040023964A1,Cn1cnc(-c2cccc(B3OCC(C)(C)CO3)c2)n1.FC(F)(F)c1cnn2c(Br)cnc2n1>>Cn1cnc(-c2cccc(Br)c2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20090143353A1,COC(=O)c1ccc(NC(C)=O)cc1O.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Br)c(NC(C)=O)cc1O,,CCOC(C)=O,,CN(C)C=O,,val
US20070149508A1,CC(C)(C)OC(=O)N1CCNCC1.O=S(=O)(Cl)c1cc(F)c(Br)cc1F>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2cc(F)c(Br)cc2F)CC1,,O,,,,val
US20100048564A1,COc1cc(F)cc(Oc2ccc([N+](=O)[O-])c(CNC(=O)OC(C)(C)C)c2)c1>>COc1cc(F)cc(Oc2ccc(N)c(CNC(=O)OC(C)(C)C)c2)c1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20140018319A1,COc1ccc(CN(c2nc(Nc3cc(C#N)cc(N4CC[C@@H](NC(=O)OC(C)(C)C)[C@H](O[Si](C(C)C)(C(C)C)C(C)C)C4)c3Cl)nn3c(C#N)cnc23)C2CC2)cc1>>CC(C)[Si](O[C@@H]1CN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC[C@H]1N)(C(C)C)C(C)C,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US05117057,CC(C)(C)NNC(=O)c1ccccn1.O=C(Cl)c1ccccc1Br>>CC(C)(C)N(NC(=O)c1ccccn1)C(=O)c1ccccc1Br,,Cc1ccccc1,,[Na+].[OH-],,val
US04668682,CC(C)Oc1ccc(N)c(C(=O)O)c1.COc1ccc(OC)c(CC(=O)Cl)c1>>COc1cccc(C(OC)C(=O)Nc2ccc(OC(C)C)cc2C(=O)O)c1,,CC(C)=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20080234277A1,COC(=O)COCCc1cccc(C)c1.NC(=O)c1cncnc1N>>Cc1cccc(CCOCc2nc3ncncc3c(=O)[nH]2)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05708174,O=C(O)c1cccc2cccnc12>>O=C(O)c1cccc2c1NCCC2,O=[Pt]=O,CCO,,,,val
US20050065191A1,COC(=O)Cl.Cc1cccc(C#CC2(O)CCCC3CNCC32)c1>>COC(=O)N1CC2CCCC(O)(C#Cc3cccc(C)c3)C2C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20030207877A1,CC(=O)c1ccsc1.CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C>>C=C(O[Si](C(C)C)(C(C)C)C(C)C)c1ccsc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120059014A1,CC(C)c1noc(N2CCC([C@H](C)CCO)CC2)n1.Oc1ccc(Br)cn1>>CC(C)c1noc(N2CCC([C@H](C)CCOc3ccc(Br)cn3)CC2)n1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080227636A1,CCCS.CCCSc1cncc(C)c1C#N.CN(C)C=O.Cc1cncc(Br)c1C#N.O>>Cc1cncc2c1C(=N)N(Cc1ccccc1)S2(=O)=O,,CN(C)C=O,,[K+].[OH-],,val
US20130075706A1,Brc1cncc(-c2nc3ccccc3n2-c2ccccc2)c1.CC1(C)OB(c2cccc(-n3c4ccccc4c4ccccc43)c2)OC1(C)C>>c1ccc(-n2c(-c3cncc(-c4cccc(-n5c6ccccc6c6ccccc65)c4)c3)nc3ccccc32)cc1,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US05968967,CCOC(=O)c1c(-c2ccc(-c3ccccn3)cc2)n(C)n(-c2ccc(C#N)cc2)c1=O>>Cn1c(-c2ccc(-c3ccccn3)cc2)c(C(=O)O)c(=O)n1-c1ccc(C#N)cc1,,O,,CCO,O=C([O-])[O-].[K+].[K+],val
US20100210674A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)OCCOc1ccc(Cl)cc1/C=C1\C(=O)Nc2cc(Cl)ccc21>>CC(C)(C)OC(=O)N1C(=O)/C(=C\c2cc(Cl)ccc2OCCO[Si](C)(C)C(C)(C)C)c2ccc(Cl)cc21,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20040162303A1,CC(=O)OCBr.COc1ccc(F)cc1C(=O)c1cnc(NC2CCNCC2)nc1N>>COC(=O)CN1CCC(Nc2ncc(C(=O)c3cc(F)ccc3OC)c(N)n2)CC1,,CN(C)C=O,,O,,val
US05569664,CC(=O)OCc1ccc(Br)cc1.CCOP([O-])OCC>>CCOP(=O)(OCC)c1ccc(COC(C)=O)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,CCN(CC)CC,,val
US03976650,CCOC(=O)CC(C)=O.COc1ccc(N)cc1OC>>CCOC(=O)C=C(C)Nc1ccc(OC)c(OC)c1,,CC(=O)O,,c1ccccc1,,val
US20100087427A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2N)C(C)C)ccc1OC.O=S(=O)(Cl)c1ccc(Oc2ccccc2)cc1>>COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)C(C)C)ccc1OC,,O,,CC#N,CC#N,val
US06291131B1,C=C(C)C(=O)O.c1ccsc1>>CC1(C(=O)O)CC2C=CC1S2,,C1CCOC1,,,,val
US20150361100A1,Nc1ncnc2c1c(I)nn2Cc1cc2ccccn2c1-c1cccnc1.OB(O)c1cc(O)cc(F)c1>>Nc1ncnc2c1c(-c1cc(O)cc(F)c1)nn2Cc1cc2ccccn2c1-c1cccnc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20120040954A1,BrC(Br)(Br)Br.Cc1cc(-c2nc3cc(OC(C)C)cc(OC(C)C)c3c(=O)[nH]2)cc(C)c1OCCO>>Cc1cc(-c2nc3cc(OC(C)C)cc(OC(C)C)c3c(=O)[nH]2)cc(C)c1OCCBr,,CN(C)C=O,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060217387A1,Nc1ccc(-c2ccc(C(F)(F)F)cc2)cn1.O=C1CCC(=O)N1Br>>Nc1ncc(-c2ccc(C(F)(F)F)cc2)cc1Br,,CC#N,,O=C([O-])O.[Na+],,val
US20140315888A1,CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc([N+](=O)[O-])cc3nc2NN)C1.COC(OC)OC>>CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc([N+](=O)[O-])cc3n3cnnc23)C1,,CCOCC,,,,val
US20050245537A1,CS(=O)(=O)c1ccc(CC2CCNCC2)cc1>>CS(=O)(=O)c1ccc(CC2CCNCC2)cc1,,O,,Cl,[Na+].[OH-],val
US05672586,C1CCOC1.CC(C)[C@@H]1COC(=O)N1.CCCCCC.O=C1NCCO1>>CC(C)[C@@H]1COC(=O)N1C(=O)C[C@@H](C)c1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20150225394A1,C=CCOC(=O)N(CC1CCN(C(=O)OC(C)(C)C)CC1)[C@@H]1C[C@H]1c1ccccc1>>C=CCOC(=O)N(CC1CCNCC1)[C@@H]1C[C@H]1c1ccccc1,,C1COCCO1,ClCCl,Cl,,val
US20020035137A1,NC(=O)c1ccc2cccc([N+](=O)[O-])c2c1>>NC(=O)c1ccc2cccc(N)c2c1,[Pd],CO,,,,val
US05114960,COC(=O)C1(C)CCCc2c(-c3ccc(Cl)cc3)noc2C1>>CC1(C(=O)O)CCCc2c(-c3ccc(Cl)cc3)noc2C1,,CO,O,[K+].[OH-],,val
US20010047099A1,CCCCC(CC)CO.Nc1cc(Cl)nc(C(=O)O)c1Cl>>CCCCC(CC)COC(=O)c1nc(Cl)cc(N)c1Cl,,O,,O=S(=O)(O)O,,val
US20110071115A1,CN(C)C=O.Cc1c(Nc2ccc(C#N)cc2Cl)nc2c(C=O)cnn2c1NC1CC1.O=C1CC(=P(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)N1>>Cc1c(Nc2ccc(C#N)cc2Cl)nc2c(C=C3NC(=O)NC3=O)cnn2c1NC1CC1,,CCO,O,,,val
US20040082611A1,CCOC(=O)C(=O)C(=O)OCC.NN=C(N)c1ccncc1>>CCOC(=O)c1n[nH]c(-c2ccncc2)nc1=O,,CCO,,,,val
US20150276753A1,C=C(CC)C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl.O=C1CCC(=O)N1O>>C=C(CC)C(=O)c1ccc(OCC(=O)ON2C(=O)CCC2=O)c(Cl)c1Cl,,ClCCl,,CO,,val
US20150073011A1,C=CCONS(=O)(=O)c1ccccc1[N+](=O)[O-].CC1=C[C@@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)OC(C)(C)C)C[C@H]1O>>C=CCON([C@H]1CN(C(=O)OC(C)(C)C)[C@H](CO[Si](C)(C)C(C)(C)C)C=C1C)S(=O)(=O)c1ccccc1[N+](=O)[O-],,Cc1ccccc1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080255092A1,CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(CCl)c2CC1.SC1=NCCS1>>CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(CSC3=NCCS3)c2CC1,,CN(C)C=O,,[H-].[Na+],,val
US20010056109A1,COc1ccc2c(c1)C(Cc1c[nH]cn1)C(c1ccccc1)C2>>Oc1ccc2c(c1)C(Cc1c[nH]cn1)C(c1ccccc1)C2,,O,,Br,,val
US20110076292A1,CO.COC(=O)C(C)(C)n1cc(-c2ccc3c(c2)OCCn2cc(-c4ncnn4C(C)C)nc2-3)cn1>>Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)(C)C(=O)O)c4)cc2OCC3)n(C(C)C)n1,,O,,[Li+].[OH-],,val
US20070060573A1,CCOc1ccc(Br)cc1C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12.OB(O)c1ccccc1>>CCOc1ccc(-c2ccccc2)cc1C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20140194418A1,Cc1cc(Nc2nc(Cc3c(Cl)cccc3Cl)c3ncn(COCC[Si](C)(C)C)c3c2C#N)ccc1N1CCN(C(=O)OC(C)(C)C)CC1>>Cc1cc(Nc2nc(Cc3c(Cl)cccc3Cl)c3nc[nH]c3c2C(N)=O)ccc1N1CCNCC1,,O,O=S(=O)(O)O,O=C([O-])O.[Na+],,val
US20080153810A1,Nc1n[nH]c2ccc([N+](=O)[O-])cc12.O=Cc1ncco1>>O=[N+]([O-])c1ccc2[nH]nc(NCc3ncco3)c2c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20120214854A1,COC(=O)C(NC(=O)c1nc(-c2ccc([N+](=O)[O-])cc2)cs1)C(C)C.O=S(=O)(Cl)c1ccc(Cl)cc1Cl>>COC(=O)C(NC(=O)c1nc(-c2ccc(NS(=O)(=O)c3ccc(Cl)cc3Cl)cc2)cs1)C(C)C,,ClCCl,,c1ccncc1,,val
US20060258770A1,C=C(C)C(=O)OCCOC(=O)CCC(=O)[O-].COC(=O)C1CCOCC1>>C=C(C)C(=O)OCCO.COC(=O)C1CCOCC1,,CCOC(C)=O,,CCN(CC)CC,,val
US05688798,C(#CC1C=CNCC1)c1ccccc1.Cc1ncc(CCl)c(N)n1>>Cc1ncc(CN2CC=C(C#Cc3ccccc3)CC2)c(N)n1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20050234036A1,CCOC(=O)CC#N.NC(=S)NCC1CC1>>Nc1cc(=O)[nH]c(=S)n1CC1CC1,,CCO,,C[O-].[Na+],,val
US20080113966A1,N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c1nnc2C1(C(F)(F)F)CC1.O=C(n1ccnc1)n1ccnc1.O=C1NCCC12CCNCC2>>O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c1nnc2C1(C(F)(F)F)CC1)N1CCC2(CCNC2=O)CC1,,C1CCOC1,ClCCl,CCN(CC)CC,,val
US05736534,COc1cc2ncnc(Cl)c2cc1OC.C[Si](C)(C)C#Cc1ccc2c(c1)NCC2>>COc1cc2ncnc(N3CCc4ccc(C#C[Si](C)(C)C)cc43)c2cc1OC,,CN1CCCC1=O,,,,val
US04457862,C=C(C)C1CCC(C)(C(=O)C2CCCC2=O)C1=C>>CC(C)C1CCC(C)(C(=O)C2CCCC2=O)C1C,[Pd],,,,,val
US20090182002A1,CN(CC1COCCO1)C(=O)OCc1ccccc1.Cl>>CNCC1COCCO1.Cl,[Pd],CCO,,,,val
US07238714B2,COC(=O)c1cc(Cl)ccc1O.O=[N+]([O-])c1ccc(Cl)nc1>>COC(=O)c1cc(Cl)ccc1Oc1ccc([N+](=O)[O-])cn1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070043065A1,Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(O[C@@H]3CCN(C(=O)OC(C)(C)C)C3)cc2c1=O>>Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(O[C@@H]3CCNC3)cc2c1=O,,C1COCCO1,,Cl,,val
US05109012,CCOC=C(C#N)C(=O)OCC.NNc1c(Cl)cc(C(F)(F)F)cc1Cl>>CCOC(=O)c1cnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N,,CCO,,,,val
US20090099187A1,COc1ccc(S(=O)(=O)Cl)c2c1C[C@@H](NC(=O)C(F)(F)F)CC2.Nc1ccc(F)c(Cl)c1>>COc1ccc(S(=O)(=O)Nc2ccc(F)c(Cl)c2)c2c1C[C@@H](NC(=O)C(F)(F)F)CC2,,ClCCl,,c1ccncc1,,val
US20160222033A1,Cc1sc2nc(Cc3cccc(C(F)(F)F)c3)cc(=O)n2c1Br.OB(O)c1cncnc1>>Cc1sc2nc(Cc3cccc(C(F)(F)F)c3)cc(=O)n2c1-c1cncnc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US08471005B2,CI.O=c1[nH]c(=S)[nH]n2c1cc1ccccc12>>CSc1nn2c(cc3ccccc32)c(=O)[nH]1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20070197512A1,COC(=O)CCN1C(=O)C(C(C)C)Oc2c(Br)cccc21>>CC(C)C1Oc2c(Br)cccc2N(CCC(=O)O)C1=O,,CO,,[Na+].[OH-],,val
US20030236278A1,O=S(=O)(CCl)c1ccccc1.O=[N+]([O-])c1cc[n+]([O-])cc1>>O=[N+]([O-])c1cc[n+]([O-])cc1CS(=O)(=O)c1ccccc1,,CS(C)=O,O,Cl,[K+].[OH-],val
US20070004772A1,Cc1nc(C(F)(F)F)ccc1Cn1nc2c(-c3ccncc3)c(Cl)ccn2c1=O.OB(O)c1ccc(F)cc1>>Cc1nc(C(F)(F)F)ccc1Cn1nc2c(-c3ccncc3)c(-c3ccc(F)cc3)ccn2c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20100075981A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CCN2CCN(c3noc4ccncc34)CC2)CC1.Cl.ClCCl>>Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3noc4ccncc34)CC2)CC1,,ClCCl,,C1COCCO1,,val
US20070265270A1,COc1ccc(C2CN(c3cnnc4cc(OC)c(O)cc34)CCO2)cc1.FC(F)(F)CI>>COc1ccc([C@H]2CN(c3cnnc4cc(OC)c(OCC(F)(F)F)cc34)CCO2)cc1,,CC(=O)N(C)C,CCOC(C)=O,[H-].[Na+],,val
US20070087346A1,Nc1c(Br)cc2c(c1[N+](=O)[O-])CCC2=O>>Nc1ccc2c(c1N)CCC2=O,[Pd],CCOC(C)=O,,CC(=O)[O-].[Na+],,val
US20080318924A1,CN1CCN(C2CCN(C(=O)Nc3cc(Oc4ccc(NC(=O)CC5(CC(=O)Nc6ccc(F)cc6)CC5)c(F)c4)ccn3)CC2)CC1.O=C(O)CCC(=O)O>>CN1CCN(C2CCN(C(=O)Nc3cc(Oc4ccc(NC(=O)CC5(CC(=O)Nc6ccc(F)cc6)CC5)c(F)c4)ccn3)CC2)CC1.O=C(O)CCC(=O)O,,CCO,,,,val
US05912247,C=CCOc1nc(N2CCNCC2)nc2ccccc12.O=C(Cl)OCc1ccccc1>>C=CCOc1nc(N2CCN(C(=O)OCc3ccccc3)CC2)nc2ccccc12,,ClC(Cl)Cl,ClCCl,CCN(CC)CC,,val
US20070179196A1,CCOC(=O)c1ncc(OC)c2c1CCN(Cc1ccc(OC)cc1)C2=O>>COc1ccc(CN2CCc3c(C(=O)O)ncc(OC)c3C2=O)cc1,,C1CCOC1,,Cl,O,val
US20050215645A1,Cc1ccc(S(=O)(=O)Oc2cccc3c(S(N)(=O)=O)cccc23)cc1>>O=S(=O)(NCc1ccccc1)c1cccc2c(O)cccc12,,CO,,Cl,[Na+].[OH-],val
US20130296373A1,COC(=O)/C=C/O[C@@H]1[C@@H](Cc2ccccc2)COC[C@H](NC(=O)OC(C)(C)C)C(=O)O[C@H]1C>>COC(=O)CCO[C@@H]1[C@@H](Cc2ccccc2)COC[C@H](NC(=O)OC(C)(C)C)C(=O)O[C@H]1C,[Pd],CCOC(C)=O,,,,val
US20040058903A1,CCOc1ccc(-c2ccccc2C(=O)Nc2ccc(N(CCc3ccccn3)C(=O)OC(C)(C)C)cc2)cc1>>CCOc1ccc(-c2ccccc2C(=O)Nc2ccc(NCCc3ccccn3)cc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06248765B1,CCc1cccc(N)c1.O=CCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CCc1cccc(NCCCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)c1,,Cc1ccccc1,,,,val
US20140323303A1,CN.COC1=C(c2c(C)cc(Br)cc2C)C(=O)C(Cc2ccc(C#N)c(S(C)(=O)=O)n2)C1>>CNc1nc(CC2CC(OC)=C(c3c(C)cc(Br)cc3C)C2=O)ccc1C#N,,C1CCOC1,,,,val
US20120238574A1,CN(C(=O)c1ccc(NC(=O)NCC2CC2)cc1)C1CCNCC1.OC(c1cccc(CBr)c1)(C(F)(F)F)C(F)(F)F>>CN(C(=O)c1ccc(NC(=O)NCC2CC2)cc1)C1CCN(Cc2cccc(C(O)(C(F)(F)F)C(F)(F)F)c2)CC1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20020022638A1,CC(C)(C)[Si](Oc1ccc(OC[C@@H](O)CNCCc2ccc(-n3c(CCC4CCCC4)nc4cccnc43)cc2)cc1)(c1ccccc1)c1ccccc1>>Oc1ccc(OC[C@@H](O)CNCCc2ccc(-n3c(CCC4CCCC4)nc4cccnc43)cc2)cc1,,CO,ClC(Cl)Cl,,,val
US20110251173A1,COc1ccc(N(C[C@@H](C)O[Si](C)(C)C(C)(C)C)C(=O)c2c(Cl)ncnc2Cl)cc1C#N>>COc1ccc(N(C[C@@H](C)O)C(=O)c2c(Cl)ncnc2Cl)cc1C#N,,C1COCCO1,Cl,,,val
US04628057,CCC[C@@H]1N[C@H](C(=O)OC)Cc2c1[nH]c1ccccc21>>CCC[C@@H]1N[C@H](C(=O)O)Cc2c1[nH]c1ccccc21,,CO,,[Na+].[OH-],,val
US04096183,COc1ccc(C(Cl)=NS(=O)(=O)C=Cc2ccc(Cl)c(Cl)c2)cc1OC.[NH4+]>>COc1ccc(C(=N)NS(=O)(=O)C=Cc2ccc(Cl)c(Cl)c2)cc1OC,,c1ccccc1,,,,val
US20140200197A1,COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H]1CN(C(=O)OC(C)(C)C)[C@H](CCc2ccccc2N)CO1)C(c1ccccc1)c1ccccc1.O=S(=O)(Cl)Cc1ccccc1>>COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H]1CN(C(=O)OC(C)(C)C)[C@H](CCc2ccccc2NS(=O)(=O)Cc2ccccc2)CO1)C(c1ccccc1)c1ccccc1,,CCOC(C)=O,ClCCl,CCN(CC)CC,O=C([O-])O.[Na+],val
US05728370,CC(=O)OCC1(COC(C)=O)Sc2cc3c(cc2S1)SC(COC(C)=O)(COC(C)=O)S3>>OCC1(CO)Sc2cc3c(cc2S1)SC(CO)(CO)S3,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20130281438A1,O=[N+]([O-])c1cccc2c1OCO2>>Nc1cccc2c1OCO2,[Ni],CCO,,,,val
US20040127574A1,COc1ccc(C(=O)Cl)cc1.NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)cc1>>COc1ccc(C(=O)NC(Cc2ccc(C(F)(F)F)cc2)C(O)c2ccc(F)cc2)cc1,,CCOC(C)=O,O,Cl,O=C([O-])O.[Na+],val
US20070099990A1,CCOC(C)=O.Cc1cc2c(c(C)c1NC(=O)NC(C)(C)C)[C@@H](c1ccc(C(C)C)cc1)CO2>>Cc1c(C=O)c2c(c(C)c1NC(=O)NC(C)(C)C)[C@@H](c1ccc(C(C)C)cc1)CO2,,ClC(Cl)Cl,,CCCCCC,,val
US20110275797A1,CC(=O)OC(C)=O.CC(C)(C)c1ccc(O)c(C(=O)O)c1>>CC(=O)Oc1ccc(C(C)(C)C)cc1C(=O)O,,ClCCl,,c1ccncc1,,val
US20130116277A1,COc1ccc2c(=O)n(-c3ccc(C=O)c(OC)c3)cc(Br)c2c1.OB(O)c1ccc(C(F)(F)F)cc1>>COc1ccc2c(=O)n(-c3ccc(C=O)c(OC)c3)cc(-c3ccc(C(F)(F)F)cc3)c2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20110028461A1,COc1ccc(CN(C(=O)[O-])[C@H](CCC(=O)Cc2ccc([N+](=O)[O-])cc2)[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(Cl)nc2)cc1>>CC(C)(C)[Si](C)(C)O[C@H](c1ccc(Cl)nc1)[C@H]1CCC(Cc2ccc([N+](=O)[O-])cc2)=N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160075657A1,C=O.NCC(O)c1cccc(OCc2ccccc2)c1>>OC1CNCc2ccc(OCc3ccccc3)cc21,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US04092304,CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)O.Cl>>CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O.Cl,,C1COCCO1,,,,val
US05760054,O=C(O)c1ccncc1S(=O)(=O)NCCCCOC1CCCCO1>>O=C1c2ccncc2S(=O)(=O)N1CCCCOC1CCCCO1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20050106691A1,CCC(=CC(=O)OC)CC>>CCC(CC)CC(=O)O,[Pd],C1COCCO1,,,,val
US20130165426A1,CCOC(=O)c1ccc2nc(Nc3ccc(OC)cc3)n(CCCN3CCCCC3)c2n1>>COc1ccc(Nc2nc3ccc(C(=O)O)nc3n2CCCN2CCCCC2)cc1,,CO,,C1CCOC1,[Li+].[OH-],val
US20130331374A1,CC1(C)C[C@H](Nc2nc(Cl)ncc2F)C[C@@H]2CCCN21.COCC1(COC)Oc2ccc(N)cc2-n2nnnc21>>COCC1(COC)Oc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2-n2nnnc21,,CC(C)O,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US05401772,COc1ccc(Oc2c(C)cc([N+](=O)[O-])cc2C)cc1C(=O)c1ccc(F)cc1>>Cc1cc([N+](=O)[O-])cc(C)c1Oc1ccc(O)c(C(=O)c2ccc(F)cc2)c1,,ClCCl,,ClB(Cl)Cl,,val
US20110028509A1,COC(=O)c1ccc(CN)cc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>COC(=O)c1ccc(CNS(=O)(=O)c2ccc(Cl)cc2)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20030144282A1,BrC(Br)(Br)Br.COC(=O)c1ccc(OCCc2c(CCCO)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1>>COC(=O)c1ccc(OCCc2c(CCCBr)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04128658,C1CN1.CN(C)Cc1ccc(CO)o1>>CN(C)Cc1ccc(COCCN)o1,,C1CCOC1,,CS(=O)(=O)O,,val
US20060074237A1,CC(C)(C)C(=O)Nc1cccc(CCl)n1.CCCNC>>CCCN(C)Cc1cccc(NC(=O)C(C)(C)C)n1,,CC(C)=O,,[I-].[K+],,val
US20150284362A1,CC1(Cn2c3ccc(F)cc3c3cc(F)ccc32)CO1.O=C1NCc2ccccc2N1Cc1ccccc1>>CC(O)(CN1Cc2ccccc2N(Cc2ccccc2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc21,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20120059028A1,CC(C)(C)CI.COC(=O)Cc1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCCC3>>COC(=O)C(CC(C)(C)C)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCCC3,,CN(C)C=O,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20110092497A1,CC(C)N1CCN(c2ccc(Nc3ncc(Br)n4ccnc34)cn2)CC1.CC1(C)OB(c2ccc3c(c2)CNC3=O)OC1(C)C.O=C1NCc2cc(-c3cnc(Nc4ccc(N5CCOCC5)cc4)c4nccn34)ccc21>>CC(C)N1CCN(c2ccc(Nc3ncc(-c4ccc5c(c4)CNC5=O)n4ccnc34)cn2)CC1.N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US04029787,CN1CCNCC1.Cl.O=C(O)c1ccc(Cl)c(S(=O)(=O)N2CCCC2)c1>>CN1CCN(c2ccc(C(=O)O)cc2S(=O)(=O)N2CCCC2)CC1.Cl,,O,,,,val
US20060025455A1,Cc1ccc(F)cc1S(=O)(=O)Cl.Nc1ccc(-c2ccccc2Cl)cn1>>Cc1ccc(F)cc1S(=O)(=O)Nc1ccc(-c2ccccc2Cl)cn1,,c1ccncc1,,,,val
US20160159809A1,Clc1nc(-c2cccnc2)nc2ccccc12.NCC(c1ccccc1)c1cccc(Cl)n1>>Clc1cccc(C(CNc2nc(-c3cccnc3)nc3ccccc23)c2ccccc2)n1,,C1CCOC1,O,CCN(C(C)C)C(C)C,,val
US05856556,CC(=NC(=O)OCc1ccc([N+](=O)[O-])cc1)N1CC[C@H](SC(=O)C[C@@H]2[C@@H]([C@@H](C)O)C(=O)N2C(C(=O)OCc2ccc([N+](=O)[O-])cc2)=C(C)C)C1.O=C(Cl)OCc1ccc([N+](=O)[O-])cc1>>CC(=NC(=O)OCc1ccc([N+](=O)[O-])cc1)N1CC[C@H](SC(=O)C[C@@H]2[C@@H]([C@@H](C)OC(=O)OCc3ccc([N+](=O)[O-])cc3)C(=O)N2C(C(=O)OCc2ccc([N+](=O)[O-])cc2)=C(C)C)C1,CN(C)c1ccncc1,ClCCl,,,,val
US20030212116A1,CI.O=C1CSC=C(c2ccccc2)N1>>CN1C(=O)CSC=C1c1ccccc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20070270438A1,CCOC(=O)[C@H]1C[C@@H](NCc2ccc(-c3nc(-c4ccc(CC(C)C)cc4)no3)cc2)C1.Cl>>CC(C)Cc1ccc(-c2noc(-c3ccc(CN[C@@H]4C[C@H](C(=O)O)C4)cc3)n2)cc1.Cl,,CCO,,[Na+].[OH-],,val
US05633374,N#CN=C(Oc1ccccc1)Oc1ccccc1.Nc1cncnc1>>N#CN=C(Nc1cncnc1)Oc1ccccc1,,CCOCC,,,,val
US05780642,NCCCCCn1ccnc1.O=C(O)COc1ccc(Cl)cc1>>O=C(COc1ccc(Cl)cc1)NCCCCCn1ccnc1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20140329825A1,Clc1ccc(I)nn1.N#C[Cu]>>N#Cc1ccc(Cl)nn1,,CC#N,,ClCCl,,val
US20090298815A1,CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(Cl)n2)s1.CS(=O)(=O)N1CCC(N)CC1>>CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(NC3CCN(S(C)(=O)=O)CC3)n2)s1,,OCC(F)(F)F,,,,val
US20120252853A1,Cc1cc2cc(Br)ccc2[nH]1.N#C[Cu]C#N>>Cc1cc2cc(C#N)ccc2[nH]1,,c1ccc2ncccc2c1,,CCOC(C)=O,Cl,val
US05281685,CCCCCOCC(OCC)OCC.CN(C)C=O>>CCCC(C)OC(C=O)=CN(C)C,,CC(Cl)Cl,,O=C([O-])[O-].[K+].[K+],,val
US20110046127A1,Nc1cnc2ccc(-c3ccccc3)nn12.O=C(Cl)c1ccccc1>>O=C(Nc1cnc2ccc(-c3ccccc3)nn12)c1ccccc1,,c1ccncc1,,,,val
US20050038035A1,CC(C)(C)OC(=O)Nc1cccc(CCN2CCc3cc(NC(=O)C4=C(c5ccc(C(F)(F)F)cc5)CCCC4)ccc3C2)n1>>Nc1cccc(CCN2CCc3cc(NC(=O)C4=C(c5ccc(C(F)(F)F)cc5)CCCC4)ccc3C2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150038488A1,CC(C)(C)OC(=O)N1CCN(c2ccc(B(O)O)cc2)CC1.COc1ccc([C@@H](C)N2C[C@H]([C@@H](C)Oc3nc(Cl)cn4ncc(C#N)c34)CC2=O)cc1>>COc1ccc([C@@H](C)N2C[C@H]([C@@H](C)Oc3nc(-c4ccc(N5CCN(C(=O)OC(C)(C)C)CC5)cc4)cn4ncc(C#N)c34)CC2=O)cc1,,C1COCCO1,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US04427589,CO.Cc1nc(Cl)c2c(n1)CN=C(c1ccccc1)c1cc(Cl)ccc1-2>>COc1nc(C)nc2c1-c1ccc(Cl)cc1C(c1ccccc1)=NC2,,C1CCOC1,,C[O-].[Na+],,val
US20120149699A1,COC(=O)c1ccc(S(=O)(=O)N(C(=O)OC(C)(C)C)c2nc3ccccn3c2C(C)C)cc1.Cl>>COC(=O)c1ccc(S(=O)(=O)Nc2nc3ccccn3c2C(C)C)cc1.Cl,,C1COCCO1,,,,val
US05770743,O=C(O)c1cccc(O)c1.OCCCCl>>O=C(OCCCCl)c1cccc(O)c1,,O=S(=O)(O)O,,,,val
US20070254892A1,CN(C)CCCl.Cc1cc([N+](=O)[O-])ccc1O>>Cc1cc([N+](=O)[O-])ccc1OCCN(C)C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20020072533A1,CCC[C@@H](C)C[C@H](CO)CC(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)Cl)cc1>>CCC[C@@H](C)C[C@H](COS(=O)(=O)c1ccc(C)cc1)CC(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,Cl,val
US04853027,COC(=O)C(Cl)C(C)=NNS(=O)(=O)c1ccc(C)cc1.COC(=O)CC(=O)c1nccnc1C>>COC(=O)c1c(C(=O)OC)c(-c2nccnc2C)n(NS(=O)(=O)c2ccc(C)cc2)c1C,,C1CCOC1,CO,Cl,[Na],val
US04977167,O=C1CCCN1C(=O)NCCN1CCC(O)(c2ccc(Cl)cc2)CC1>>O=C1CCCN1C(=O)NCCN1CC=C(c2ccc(Cl)cc2)CC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20030055047A1,COC(=O)c1ccc(I)cc1OC>>COc1cc(I)ccc1C(=O)O,,C1CCOC1,,[Na+].[OH-],,val
US05091419,CCCCCCCN.CCN(CC)CC.ClCCl.O=C(Cl)c1ccc(C(=O)Cl)cc1>>CCCCCCCNC(=O)c1ccc(C(=O)NCCCCCCC)cc1,,ClCCl,,,,val
US20140342086A1,CCC(O)Br.COC(=O)C=Cc1ccc(O)cc1>>COC(=O)/C=C/c1ccc(OCCCBr)cc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(Oc3cnccn3)cc(CC)c21>>CCc1cc(Oc2cnccn2)cc2c1C(CC(=O)O)OB2O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20080193411A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=C(NCc1ccc(Br)cc1)C1CC1>>CC1(C)OB(c2ccc(CNC(=O)C3CC3)cc2)OC1(C)C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CS(C)=O,,CC(=O)[O-].[K+],,val
US20060160770A1,C[Si](C)(C)C#C/C=C\c1ccccn1.OCc1ccccc1>>c1ccc(COCc2ccc3ccccn23)cc1,,Cc1ccccc1,,[Cs+].[F-],,val
US20110305637A1,OCCCBr.c1ccc2nc(COc3ccc(-c4n[nH]cc4-c4ccncc4)cc3)ccc2c1>>OCCCn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ccccc4n3)cc2)n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140235583A1,NO.O=Cc1ncc(NC(=O)C(c2ccccc2)c2ccccc2)c(O)n1>>O=C(Nc1cnc(C=NO)nc1O)C(c1ccccc1)c1ccccc1,,O,,Cl,CC(=O)[O-].[Na+],val
US04012499,NC(=O)c1ccc2c(c1)S(=O)(=O)c1ccccc1C2=O>>N#Cc1ccc2c(c1)S(=O)(=O)c1ccccc1C2=O,,CN(C)C=O,,O=S(Cl)Cl,,val
US20080255078A1,CCCC(=O)c1cccc(O)c1.CCOC(=O)CCCBr>>CCCC(=O)c1cccc(OCCCC(=O)OCC)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150057265A1,Cn1ncc([N+](=O)[O-])c1N1CCC[C@H](NC(=O)OC(C)(C)C)C1>>Cn1ncc(N)c1N1CCC[C@H](NC(=O)OC(C)(C)C)C1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20120046267A1,CC(C)(C)OC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cccc6ccsc56)cc34)cn2)CC1>>Nc1ncc(-c2cnn(C3CCNCC3)c2)c2cc(-c3cccc4ccsc34)oc12,,ClCCl,,Cl,,val
US20050119295A1,C=O.Clc1ccc(-c2nn(Cc3ccccc3)c3c2CCNCC3)cc1>>CN1CCc2c(-c3ccc(Cl)cc3)nn(Cc3ccccc3)c2CC1,,ClCCCl,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130072427A1,Cn1ncc2c1CNC2.N#Cc1c(Cl)ncnc1Cl>>Cn1ncc2c1CN(c1ncnc(Cl)c1C#N)C2,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20080058340A1,CCCCOS(=O)(=O)CCCCl>>CCCCOS(=O)(=O)C1CC1,,C1CCOC1,,[Li]CCCC,,val
US06329400B1,CC(C)(C)OC(=O)N[C@H](C(=O)O)C(C)(C)C.Nc1cccnc1>>CC(C)(C)OC(=O)N[C@H](C(=O)Nc1cccnc1)C(C)(C)C,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20090062274A1,CCNc1nc(SC)nc(C)c1C(=O)OCC>>CCNc1nc(SC)nc(C)c1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130261116A1,CC(C)CBr.Cn1cc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cn1>>CC(C)Cn1cc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20100190761A1,CC(C)C(C)(c1ccc(C#N)cc1)c1ccc(C(=O)Cc2ccccn2)cc1>>CC(C)C(C)(c1ccc(C#N)cc1)c1ccc(C(O)Cc2ccccn2)cc1,,CCO,,[BH4-].[Na+],,val
US04084955,CCOC(=O)Cn1nc(Br)c(Br)c1Br.N>>NC(=O)Cn1nc(Br)c(Br)c1Br,,CCO,,,,val
US04728653,CCOC(=O)/C=C/c1cc(-n2ncnn2)cc(C)c1N>>Cc1cc(-n2ncnn2)cc2ccc(=O)[nH]c12,,Cl,,O=C([O-])[O-].[Na+].[Na+],,val
US20100056533A1,Nc1ccc(C(=O)O)c([N+](=O)[O-])c1.O=C(Cl)OCC1c2ccccc2-c2ccccc21>>O=C(Nc1ccc(C(=O)O)c([N+](=O)[O-])c1)OCC1c2ccccc2-c2ccccc21,,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20070191447A1,CNc1ccccc1.O=C(Cl)C(F)(F)Br>>CN(C(=O)C(F)(F)Br)c1ccccc1,,CCOC(C)=O,,CCN(CC)CC,,val
US20090047223A1,CC/C=C\CCO.CCOC(=O)C=CC(=O)Cl>>CC/C=C\CCOC(=O)/C=C/C(=O)OCC,CN(C)c1ccncc1,COC(C)(C)C,,c1ccncc1,,val
US05908697,CCCCCCCCCCCCCCCC(=O)O.OCC1OC(OC2(CO)OC(CO)C(O)C2O)C(O)C(O)C1O>>C=CC(O)CCCCC,,O,,,,val
US05405854,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OCCNCc1cccnc1>>CC(C)(C)OC(=O)N(CCO)Cc1cccnc1,,C1COCCO1,,,,val
US20120149681A1,CC(C)=CC(=O)Cl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(C(F)(F)F)oc(=O)c1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20130102590A1,O=[N+]([O-])c1ccc2c(c1)CC(N1CCCC1)C2>>Nc1ccc2c(c1)CC(N1CCCC1)C2,[Pd],CO,,,,val
US05086070,COc1ccccc1C(=O)c1cccc2c1ccn2C>>Cn1ccc2c(C(=O)c3ccccc3O)cccc21,,ClCCl,,Cl,c1ccncc1,val
US20030220368A1,Brc1ccccc1OCC1CCCCC1.O=CCC1CCN(Cc2ccccc2)CC1>>OC(CC1CCN(Cc2ccccc2)CC1)c1ccccc1OCC1CCCCC1,,C1CCOC1,,O,[Li]CCCC,val
US20130005997A1,Cc1ccc(S(=O)(=O)O)cc1.OCC(O)(C(F)(F)F)C(F)(F)F>>Cc1ccc(S(=O)(=O)OCC(O)(C(F)(F)F)C(F)(F)F)cc1,,c1ccncc1,,Cc1ccccc1,Cl,val
US20110049427A1,CCc1ccc(-c2ccc(B(O)O)c(F)c2)cc1.O=Cc1ccc(Br)s1>>CCc1ccc(-c2ccc(-c3ccc(C=O)s3)c(F)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,C1CCOC1,O=C([O-])[O-].[Na+].[Na+],val
US20090247507A1,CC(c1ccncc1)N1CCN(c2c(Br)cnc(N)c2[N+](=O)[O-])CC1.CN(C)c1ccc(-c2nc3c(N4CCN(C(=O)Nc5ccccc5)CC4)c(Br)cnc3[nH]2)cc1.CN1CCN(Cc2cccc(C=O)c2)CC1>>CC(c1ccncc1)N1CCN(c2c(Br)cnc3[nH]c(-c4cccc(CN5CCN(C)CC5)c4)nc23)CC1,,CCO,CN(C)C=O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US05663368,BrCc1ccccc1.O=C1COc2cc(O)ccc21>>O=C1COc2cc(OCc3ccccc3)ccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20030018200A1,CSSC.Cc1cccc(N)c1C>>CSc1cccc(C)c1C,[Cu],,,CC(C)(C)ON=O,,val
US20070037974A1,CC(=O)N1CCNCC1.C[C@H](C=O)NC(=O)OC(C)(C)C>>CC(=O)N1CCN(C[C@@H](C)NC(=O)OC(C)(C)C)CC1,,CC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20080085890A1,CN(CCN1CCCC1)c1ccc(N)cc1.CO/C=C1/C(=O)NC(=O)c2ccc(Br)cc21>>CN(CCN1CCCC1)c1ccc(N/C=C2\C(=O)NC(=O)c3ccc(Br)cc32)cc1,,CN(C)C=O,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20160244409A1,CC1(C)C=CN(C(C)(C)C)CC1.O=C(Cl)c1ccc(Br)cc1>>CC1(C)CCN(C(C)(C)C)C=C1C(=O)c1ccc(Br)cc1,,ClCCl,,CCN(CC)CC,,val
US20040157866A1,Cl.Nc1cccc(CC(=O)N2CCc3cc(NC(=O)c4ccccc4-c4ccc(C(F)(F)F)cc4)ccc32)n1>>Cl.Nc1cccc(CC(=O)N2CCc3cc(NC(=O)c4ccccc4-c4ccc(C(F)(F)F)cc4)ccc32)n1,,CO,,CC(C)OC(C)C,,val
US20150018309A1,CC(C)(C)OC(=O)N1CC(N=[N+]=[N-])(c2ccccc2)C1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.[N-]=[N+]=NC1(c2ccccc2)CNC1,,ClCCl,,,,val
US20160108436A1,C=CCCCC.C=CCCCCCCCCCCO>>CCCC/C=C\CCCCCCCCCCO,,Cc1ccccc1,,,,val
US20030065187A1,CC(C)O.COc1ccc(I)cc1>>COc1ccc(OC(C)C)cc1,[Cu]I,CC(C)O,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US20130150343A1,CN(C)C1(c2nnc3ccc(O[C@@H]4CC[C@H](N)c5ccccc54)cn23)CCCC1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(C5(N(C)C)CCCC5)n4c3)c3ccccc32)cc1,,C1COCCO1,CCOC(C)=O,CCN(C(C)C)C(C)C,O,val
US20140343285A1,CC[C@@H]([C@H](C)OCc1ccccc1)n1ncn(-c2ccc(N3CCN(c4ccc(O)cc4)CC3)cc2)c1=O.Cc1ccc(S(=O)(=O)OC[C@@H]2CO[C@@](Cn3cncn3)(c3ccc(F)cc3F)C2)cc1>>CC[C@H]([C@H](C)OCc1ccccc1)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@@H]5CO[C@@](Cn6cncn6)(c6ccc(F)cc6F)C5)cc4)CC3)cc2)c1=O,,CS(C)=O,,O,[Na+].[OH-],val
US20110237565A1,CC(C)(C)OC(=O)N1CCN(c2ncc(Br)c(N=CNO)n2)CC1>>Brc1cnc(N2CCNCC2)n2ncnc12,,[K+],[OH-],,,val
US04680301,CC1CCCN(c2cc3nc(C(C)(C)C)sc3cc2[N+](=O)[O-])C1>>CC1CCCN(c2cc3nc(C(C)(C)C)sc3cc2N)C1,[Ni],CO,,,,val
US06005000,C1CCOC1.CC(C)C[Mg]Br.CC1(c2ccccc2)OC(=O)C(O)=C1O.CCOC(=O)C(=O)c1ccc(-c2ccccc2)cc1>>CC(C)CC1(c2ccc(-c3ccccc3)cc2)OC(=O)C(OCc2ccccc2)=C1O,,C1CCOC1,,ClC(Cl)Cl,,val
US20150344423A1,CCOC(=O)c1cc(O)[nH]n1.ClC1CCCCC1>>CCOC(=O)c1cc(OC2CCCCC2)[nH]n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04028375,C=CCCNCC=O.COc1nnc(N=C=O)s1>>C=CCCN(CC=O)C(=O)Nc1nnc(OC)s1,,c1ccccc1,,,,val
US20090186879A1,C1COCCN1.Cc1nc(OS(=O)(=O)C(F)(F)F)ccc1N1CCCn2c1nc1c(Cl)ccc(C(OC(F)F)C(F)(F)F)c12>>Cc1nc(N2CCOCC2)ccc1N1CCCn2c1nc1c(Cl)ccc(C(OC(F)F)C(F)(F)F)c12,,CN(C)C=O,O,,,val
US20030229051A1,CCOC(=O)/C=C/C(=O)[O-].Nc1ccc2c(Nc3cccc(Br)c3)ncnc2c1>>CCOC(=O)C=CC(=O)Nc1ccc2c(Nc3cccc(Br)c3)ncnc2c1,,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20120252802A1,CCOC(=O)C(C)C.COc1cccc(CCl)c1>>CCOC(=O)C(C)(C)Cc1cccc(OC)c1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20100298347A1,CCOC(=O)c1cc(-c2ccsc2)c2ccc(O)cc2c1.Cc1cc(F)cc(C)c1CBr>>Cc1cc(F)cc(C)c1COc1ccc2c(-c3ccsc3)cc(C(=O)O)cc2c1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US05407936,CC(C)N.O=[N+]([O-])c1cc(Cl)ccc1Cl>>CC(C)Nc1ccc(Cl)cc1[N+](=O)[O-],,O,,,,val
US20040127574A1,CCOC(=O)C(Cc1ccc2c(c1)OC(F)(F)C(F)(F)O2)C(O)c1ccc(F)cc1>>O=C(O)C(Cc1ccc2c(c1)OC(F)(F)C(F)(F)O2)C(O)c1ccc(F)cc1,,CO,,[Na+].[OH-],,val
US20160009662A1,CCOC(=O)C[C@H](c1cccc(O)c1)C1CC1.COc1ccc(F)c(-c2ncc(CO)nc2Br)c1>>CCOC(=O)C[C@H](c1cccc(OCc2cnc(-c3cc(OC)ccc3F)c(Br)n2)c1)C1CC1,,ClCCl,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140018325A1,CCOC(=O)[C@@H](N)CC(F)CCNC(=O)[C@@H](NC(=O)OC)C(c1ccccc1)c1ccccc1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CCOC(=O)[C@H](CC(F)CCNC(=O)[C@@H](NC(=O)OC)C(c1ccccc1)c1ccccc1)NS(=O)(=O)c1ccc([N+](=O)[O-])cc1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20070149533A1,Nc1cc(/C=C/N2C(=O)c3ccccc3C2=O)cc(C(F)(F)F)c1>>O=C1NC(=O)c2ccccc21,[Pd],C1CCOC1,,[H][H],,val
US20120302573A1,COc1c(N)cccc1Cl.O=C(N=C=S)c1ccccc1>>COc1c(Cl)cccc1NC(N)=S,,CC(C)=O,,O,,val
US20140294898A1,C[C@@H](c1cn(C(=O)OC(C)(C)C)c2ccccc12)[C@H](N=[N+]=[N-])C(=O)O>>C[C@@H](c1cn(C(=O)OC(C)(C)C)c2ccccc12)[C@H](N)C(=O)O,[Pd],CO,,N#N,,val
US20060030612A1,C[Si](C)(C)N=[N+]=[N-].N#Cc1ccc(COc2cccc(-c3c4cccc(C(F)(F)F)c4nn3Cc3ccccc3)c2)cc1>>FC(F)(F)c1cccc2c(-c3cccc(OCc4ccc(-c5nnn[nH]5)cc4)c3)n(Cc3ccccc3)nc12,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US06303593B1,OCCC1CCN(Cc2ccccc2)CC1.c1ccc(SSc2ccccc2)cc1>>c1ccc(CN2CCC(CCSc3ccccc3)CC2)cc1,,C1CCOC1,,CCCCP(CCCC)CCCC,,val
US20020052497A1,C=CCC(C)NC.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=CCC(C)N(C)C(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20110245205A1,CC(C)(C)OC(=O)N1CCC(C(C)(O)c2ncc(-c3cccc(Nc4nccc(C(F)(F)F)n4)c3)s2)CC1>>CC(O)(c1ncc(-c2cccc(Nc3nccc(C(F)(F)F)n3)c2)s1)C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100310512A1,Br.[N-]=[N+]=CC(=O)c1ccc(Br)c2ccccc12>>O=C(CBr)c1ccc(Br)c2ccccc12,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US04367234,C1CCOC1.CCOC(=N)C(O)c1c(C)ccc2ccccc12>>Cc1ccc2ccccc2c1C1OC(=O)NC1=O,,Cc1ccccc1,,Cl,,val
US20060025474A1,CCC(CC)(c1ccc(O)c(C)c1)c1ccc(CCC(O)C(C)(C)C)c(C)c1.CCOC(=O)CCCCCBr>>CCOC(=O)CCCCCOc1ccc(C(CC)(CC)c2ccc(CCC(O)C(C)(C)C)c(C)c2)cc1C,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20050171180A1,CCC(CC)C(N=[N+]=[N-])c1ccnn1Cc1ccc(OC)cc1>>CCC(CC)C(N)c1ccnn1Cc1ccc(OC)cc1,[Pd],CO,,,,val
US20100029678A1,O=C(O[C@H]1CO[C@@H]2[C@@H](OC(=O)c3ccccc3)CO[C@H]12)c1ccccc1>>O[C@H]1CO[C@@H]2[C@@H](O)CO[C@H]12,,C1CCOC1,,CO,[Na+].[OH-],val
US20080058308A1,COC(=O)C1CC2C=CC1(OC)CC2>>COC(=O)C1CC2CCC1(OC)CC2,[Pd],CO,,,,val
US20030064991A1,C1CCNCC1.Cc1[nH]c2ccc(CCOS(C)(=O)=O)cc2c1C(=O)OCc1ccccc1>>Cc1[nH]c2ccc(CCN3CCCCC3)cc2c1C(=O)OCc1ccccc1,,C1COCCO1,,,,val
US05739333,CC(C)(C)c1ccc(S(=O)(=O)Nc2nc(-c3ncccn3)nc(OCCO)c2-c2cccs2)cc1.Clc1ncc(Br)cn1>>CC(C)(C)c1ccc(S(=O)(=O)Nc2nc(-c3ncccn3)nc(OCCOc3ncc(Br)cn3)c2-c2cccs2)cc1,,C1CCOC1,CC(=O)N(C)C,Cl,[H-].[Na+],val
US08501732B2,CN(C)C(=O)c1c(CN=[N+]=[N-])c(=O)c2ccc(Cl)cc2n1-c1ccccc1.Cl>>CN(C)C(=O)c1c(CN)c(=O)c2ccc(Cl)cc2n1-c1ccccc1.Cl,O=[Pt]=O,CCOC(C)=O,ClCCl,,,val
US20070265262A1,NCc1ccc(Br)cc1.O=C(Cl)C1CC1>>O=C(NCc1ccc(Br)cc1)C1CC1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20030225283A1,COC(=O)[C@@H]1CSCC[C@@H]1O.S=C(n1ccnc1)n1ccnc1>>COC(=O)[C@@H]1CSCC[C@@H]1OC(=S)n1ccnc1,,C1CCOC1,CCOC(C)=O,c1ccncc1,,val
US04140716,CNc1ccccc1.O=CNc1ccccc1>>CN(C=O)c1ccccc1,,CO,,Cl,[Na],val
US20050261495A1,CN1CCC2=C(C=CCC2)C(=NO)C1=O>>CN1CCC2=C(C=CCC2)C(N)C1=O,,ClCCl,,CCO,[Na+].[OH-],val
US20040132727A1,CCCC(CCC)OC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl.CCI>>CCCC(CCC)OC(=O)N(CC)c1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl,,O,,CN(C)C=O,[H-].[Na+],val
US20040204455A1,COC(=O)c1cccc2ccccc12>>O=C(O)c1cccc2ccccc12,,CO,O,[Li+].[OH-],,val
US04479949,CC(=O)N1c2ccccc2SC1c1ccccc1O.CN(C)CCCCl>>CC(=O)N1c2ccccc2SC1c1ccccc1OCCCN(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20110152273A1,COC(=O)c1c(C)nc(Cl)nc1Cl.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>COC(=O)c1c(C)nc(Cl)nc1-c1cnn(C)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,[F-].[K+],,val
US05849911,CC[C@H](C)[C@H](NC(=O)OC)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2cncs2)cc1)NC(=O)OC(C)(C)C>>CC[C@H](C)[C@H](NC(=O)OC)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(N)Cc1ccc(-c2cncs2)cc1,,O=CO,,,,val
US20100144745A1,CC1CCN(C(=O)OC(C)(C)C)CCC1=O.ClCCl>>CC1CCNCCC1=O.Cl,,O=C(O)C(F)(F)F,,,,val
US20070225292A1,Cc1ccc(C(=O)Cl)c2ccccc12.Nc1cccnc1C(=O)NCC1CCCCC1>>Cc1ccc(C(=O)Nc2cccnc2C(=O)NCC2CCCCC2)c2ccccc12,CN(C)c1ccncc1,ClCCl,,,,val
US20160039838A1,COc1cc2ncnc(Nc3ccc(F)c(Cl)c3F)c2cc1N.O=C(Cl)/C=C/CBr>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3F)c2cc1NC(=O)/C=C/CBr,,C1CCOC1,,O,,val
US20080306053A1,N#Cc1ccccc1N.NS(N)(=O)=O>>NC1=NS(=O)(=O)Nc2ccccc21,,O,,C1CCC2=NCCCN2CC1,,val
US20090156612A1,CCOP(OCC)OCC.FC(F)(F)Oc1ccccc1CBr>>CCOP(=O)(Cc1ccccc1OC(F)(F)F)OCC,,Cc1ccccc1,,,,val
US20150218096A1,COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C4NC(=O)NC4=O)ccc23)c(F)c1>>O=C1NC(=O)C(c2ccc3c(-c4ccc(C(=O)O)cc4F)nn(C(=O)c4c(Cl)cccc4C(F)(F)F)c3c2)N1,,O,,Cl,[Li]O,val
US20140336377A1,O=S(Cl)Cl.OCc1cccc(OCC(F)(F)F)n1>>FC(F)(F)COc1cccc(CCl)n1,,ClCCl,,,,val
US04327103,Cc1[nH]c2ccccc2c1CCCBr.O=C(c1ccc(F)cc1)C1CCNCC1>>Cc1[nH]c2ccccc2c1CCCN1CCC(C(=O)c2ccc(F)cc2)CC1,,CCOCC,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100022539A1,ClCCl.O=S(=O)(Nc1ccccc1)C(F)(F)F.O=S(=O)(Oc1ccc(CN2CCCCC2)cn1)C(F)(F)F.Oc1ccc(CN2CCCCC2)nc1>>C(#Cc1ccc(CN2CCCCC2)cn1)CCN1CCCCC1.N,,ClCCl,,,,val
US20150197530A1,CCOC(=O)Cc1cc(S(=O)(=O)c2ccc(OC)cc2)sc1-c1ccc(Cl)c(Cl)c1>>COc1ccc(S(=O)(=O)c2cc(CC(=O)O)c(-c3ccc(Cl)c(Cl)c3)s2)cc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20040058903A1,Cc1ccc(-c2ccccc2C(=O)Nc2ccc(N)cc2)cc1.OCCc1ccccn1>>Cc1ccc(-c2ccccc2C(=O)Nc2ccc(NCCc3ccccn3)cc2)cc1,[Ni],C1COCCO1,,CS(=O)(=O)O,,val
US05786367,C=CCOc1ccc2c(c1)CCC(=O)N2.CC(C)=CCBr>>C=CCOc1ccc2c(c1)CCC(=O)N2CC=C(C)C,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US20160002241A1,Clc1ncc2[nH]ncc2n1.O=C1CCC(=O)N1I>>Clc1ncc2[nH]nc(I)c2n1,,CN(C)C=O,,,,val
US06900200B2,COc1cc2c(cc1OC)NCc1cccn1C2.Cc1cc(C(=O)Cl)ccc1Br>>COc1cc2c(cc1OC)N(C(=O)c1ccc(Br)c(C)c1)Cc1cccn1C2,,ClCCl,,CCN(CC)CC,,val
US20160272621A1,O=C(c1cc(F)ncc1Br)C1CC1.OCCO>>Brc1cnccc1C1OCCO1,,CCOC(C)=O,c1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20060205739A1,C=CCBr.COc1ccc(O)c(C(=O)c2oc3ccc(Cl)cc3c2N)c1>>C=CCOc1ccc(OC)cc1C(=O)c1oc2ccc(Cl)cc2c1N,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05466706,CN.Cn1c2ccc(Cl)cc2n2c(CC(=O)O)c(-c3ccccc3)nc12>>CNC(=O)Cc1c(-c2ccccc2)nc2n(C)c3ccc(Cl)cc3n12,,C1CCOC1,,Cl,,val
US20080103129A1,O=C(CSc1ccc(F)cc1)N(CCCCBr)OC(c1ccccc1)(c1ccccc1)c1ccccc1.O=C(OO)c1cccc(Cl)c1>>O=C(CS(=O)(=O)c1ccc(F)cc1)N(CCCCBr)OC(c1ccccc1)(c1ccccc1)c1ccccc1,,ClCCl,,O,,val
US20140045819A1,CC(=O)NN.S=C1CCc2cc(Br)c(Cl)cc2N1>>Cc1nnc2n1-c1cc(Cl)c(Br)cc1CC2,,CCCCO,,,,val
US20070135461A1,CS(=O)(=O)Cl.O[C@@H]1CC[C@@H](CCOC(c2ccccc2)(c2ccccc2)c2ccccc2)CC1>>CS(=O)(=O)O[C@@H]1CC[C@@H](CCOC(c2ccccc2)(c2ccccc2)c2ccccc2)CC1,,ClC(Cl)Cl,,,,val
US20150329538A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.Cc1nc2cccc(Br)c2nc1F>>CC(=O)c1cccc2nc(C)c(F)nc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,Cl,,val
US20120196863A1,FC(F)Oc1ccc(C2(c3cccc(Br)c3)COCC(=S)N2)cn1.N>>NC1=NC(c2ccc(OC(F)F)nc2)(c2cccc(Br)c2)COC1,,CO,,,,val
US20140065136A1,CC1(C)COc2c(nc(Cl)nc2N2CCOCC2)O1.CC1(C)OB(c2cnc(N)nc2)OC1(C)C>>CC1(C)COc2c(nc(-c3cnc(N)nc3)nc2N2CCOCC2)O1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20110077290A1,CC(C)(C)[Si](C)(C)OCc1ccc(C(=O)NN)cc1[N+](=O)[O-].CC(C)O.CC1=CS(=C=O)C(c2ccc(C(C)(C)C)cc2)=C1O>>CC(=NNC(=O)c1ccc(CO)c([N+](=O)[O-])c1)c1csc(-c2ccc(C(C)(C)C)cc2)c1O,,CC(C)O,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20080070894A1,O=C1CCN(C(=O)C(F)(F)F)CC1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C(N1CC=C(OS(=O)(=O)C(F)(F)F)CC1)C(F)(F)F,,C1CCOC1,,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20130053409A1,C=CC(=O)Cl.COc1cc(N2CC3(CCCN3C)C2)c(N)cc1Nc1nccc(-c2cnn3ccccc23)n1>>C=CC(=O)Nc1cc(Nc2nccc(-c3cnn4ccccc34)n2)c(OC)cc1N1CC2(CCCN2C)C1,,CO,ClCCl,,,val
US20110015119A1,COC(=O)CBr.O=[N+]([O-])c1ccc(OCCO)cc1>>COC(=O)COCCOc1ccc([N+](=O)[O-])cc1,,C1CCOC1,,[H-].[Na+],,val
US04638088,Cc1cc([N+](=O)[O-])c(C)c(Cl)c1Oc1ccc(-c2ccccc2)cc1Cl>>Cc1cc(N)c(C)c(Cl)c1Oc1ccc(-c2ccccc2)cc1Cl,[Pt],Cc1ccccc1,,,,val
US20070259907A1,CCCc1nc2cnc3cc(Br)ccc3c2s1.O=C(OO)c1cccc(Cl)c1>>CCCc1nc2c[n+]([O-])c3cc(Br)ccc3c2s1,,ClCCl,,,,val
US04767760,O=S(Cl)Cl.O=c1cnn(-c2ccc(C(O)c3ccc(Cl)cc3Cl)c(Cl)c2)c(=O)[nH]1>>O=c1cnn(-c2ccc(C(Cl)c3ccc(Cl)cc3Cl)c(Cl)c2)c(=O)[nH]1,,ClC(Cl)Cl,,,,val
US20090012084A1,COc1cc2nnc(C#N)c(Nc3ccc(C)cc3F)c2cc1Br.OB(O)c1ccncc1>>COc1cc2nnc(C#N)c(Nc3ccc(C)cc3F)c2cc1-c1ccncc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(=O)N(C)C,O,O=C([O-])[O-].[K+].[K+],,val
US20150307507A1,CCOC(=O)c1ccc(-c2cccnn2)s1>>O=C(O)c1ccc(-c2cccnn2)s1,,C1CCOC1,O,[Li]O,,val
US20020045615A1,COc1ccc(-c2ccccc2)c2sc(Cl)nc12.NCc1cccnc1>>COc1ccc(-c2ccccc2)c2sc(NCc3cccnc3)nc12,,C1COCCO1,,,,val
US20060148858A1,CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1C(O)CC.CCOC(=O)C(C)(C)c1ccc(O)cc1>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1ccc(C(C)(C)C(=O)O)cc1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20150057265A1,CC(C)(C)OC(=O)NC1CCc2ccc(B3OC(C)(C)C(C)(C)O3)cc21.Cn1ncc([N+](=O)[O-])c1Cl>>Cn1ncc([N+](=O)[O-])c1-c1ccc2c(c1)C(NC(=O)OC(C)(C)C)CC2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20100152160A1,COc1cc2c(cc1Cl)NCC(C(=O)N1CCC(C#N)(Cc3ccc(F)cc3)CC1)O2.N#CBr>>COc1cc2c(cc1Cl)N(C#N)CC(C(=O)N1CCC(C#N)(Cc3ccc(F)cc3)CC1)O2,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US03936418,Cc1ccc(O)cc1.Nc1ccccc1[N+](=O)[O-].O=N[O-]>>Cc1ccc(O)c(-n2nc3ccccc3n2)c1,,[Na+],[OH-],Cl,,val
US20120010228A1,CC(C)(C)OC(=O)c1ccccc1N1CN(c2ccccc2)C2(CCNCC2)C1=O.O=C(CCCI)c1ccccc1>>CC(C)(C)OC(=O)c1ccccc1N1CN(c2ccccc2)C2(CCN(CCCC(=O)c3ccccc3)CC2)C1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150087508A1,CC1=CC(O/C=C2\CCCCN(C(=O)OC(C)(C)C)C2=O)OC1=O>>CC1=CC(O/C=C2\CCCCNC2=O)OC1=O,,ClCCl,,Cl,,val
US04749705,COc1cc2nc(Cl)nc(Cl)c2cc1OC.N>>COc1cc2nc(Cl)nc(N)c2cc1OC,,C1CCOC1,,,,val
US20080176832A1,CC(C)(C)OC(=O)N1CCc2cn(-c3ccc(NS(C)(=O)=O)cc3)nc2CC1>>CS(=O)(=O)Nc1ccc(-n2cc3c(n2)CCNCC3)cc1,,C1COCCO1,CO,Cl,,val
US20020019527A1,Cc1ccccc1-c1cc(N(Cc2ccccc2)Cc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)ccc1C#N>>Cc1ccccc1-c1cc(N(Cc2ccccc2)Cc2cnc[nH]2)ccc1C#N,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20160207883A1,CI.O=C(O)c1ccc(Br)c(F)c1>>COC(=O)c1ccc(Br)c(F)c1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20100210672A1,Cc1noc(-c2cnc(=O)[nH]c2O)n1.FC(F)(F)c1ccc([C@]23C[C@H]2CN(CCCCl)C3)cc1>>Cc1noc(-c2cn(CCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)c(=O)[nH]c2=O)n1,,CCOC(C)=O,CS(C)=O,CCN(C(C)C)C(C)C,[I-].[Na+],val
US20080293776A1,CCc1ccnc(Cc2ccc(N3CC(=O)N(CC[Si](C)(C)C)S3(=O)=O)c(OCc3ccccc3)c2)c1>>CCc1ccnc(Cc2ccc(N3CC(=O)NS3(=O)=O)c(OCc3ccccc3)c2)c1,,CN(C)C=O,,[Cs+].[F-],,val
US04238494,CC(=O)CN.CSC(=C[N+](=O)[O-])S(C)=O>>CSc1[nH]cc(C)c1[N+](=O)[O-],,CO,,Cl,[K+].[OH-],val
US05275924,C=CC(=O)O.CNc1ccccc1>>CN(CCC(=O)O)c1ccccc1,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20120214803A1,BrBr.CN1C(c2ccc(F)cc2)c2ccc3cccnc3c2NS1(=O)=O>>CN1C(c2ccc(F)cc2)c2cc(Br)c3cccnc3c2NS1(=O)=O,,C1COCCO1,ClC(Cl)Cl,,,val
US20160106842A1,CN(C)Cc1cc(OCCC2COC(C)(C)O2)cc(OCCC2COC(C)(C)O2)c1>>CN(C)Cc1cc(OCCC(O)CO)cc(OCCC(O)CO)c1,,CO,,Cl,,val
US20100216814A1,COc1ccc(C(C)=CBr)cn1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>COc1ccc(/C(C)=C/n2c3c(c4cc(C)ccc42)CN(C)CC3)cn1,[Cu]I,CN(C)C=O,O,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US09153785B2,BrBr.CCCCC(CO)CCCC>>CCCCC(CBr)CCCC,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160229853A1,CC(C)(C)[Si](C)(C)OCc1cc2cc(Cl)cc(F)c2[nH]1.O=S1(=O)CC=CC1>>CC(C)(C)[Si](C)(C)OCc1cc2cc(Cl)cc(F)c2n1C1CCS(=O)(=O)C1,,CN(C)C=O,O,[H-].[Na+],,val
US20090036448A1,CC(C)(C)OC(=O)N[C@H]1CC[C@@H](N)CC1.Cc1cnc(Cl)nc1Cl>>Cc1cnc(Cl)nc1N[C@@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20140005164A1,CC(=O)NC(=N)N.COc1ccc2c(c1)n(C[C@@H]1CC[C@@H](C(=O)CBr)CC1)c(=O)n2C>>COc1ccc2c(c1)n(C[C@@H]1CC[C@@H](c3c[nH]c(NC(C)=O)n3)CC1)c(=O)n2C,,CN(C)C=O,,,,val
US20130116216A1,C=CC(=O)Cl.Nc1ccc(S(=O)(=O)NCCN2CCOCC2)cc1>>C=CC(=O)Nc1ccc(S(=O)(=O)NCCN2CCOCC2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080096903A1,NS(=O)(=O)Cl.Nc1nc(F)nc2c1nc(Cc1cc3c(cc1I)OCO3)n2CCCCCO>>Nc1nc(F)nc2c1nc(Cc1cc3c(cc1I)OCO3)n2CCCCCOS(N)(=O)=O,,CN(C)C=O,,O=C([O-])[O-].[Ca+2],,val
US05032583,Cc1nc(Cl)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1.N[C@H]1CC[C@H](O)CC1>>Cc1nc(N[C@@H]2CC[C@@H](O)CC2)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1,,CC(C)O,,Cl,,val
US20050124656A1,CC(C)(C)OC(=O)N(Cc1ccc(C(=O)O)cc1)Cc1ccc(C(F)(F)F)cc1.CCCCCCCCCCCC(=N)NO>>CCCCCCCCCCCC(=N)NOC(=O)c1ccc(CN(Cc2ccc(C(F)(F)F)cc2)C(=O)OC(C)(C)C)cc1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US04356118,CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C.Cl>>CC[C@H](C)[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C.Cl,,C1COCCO1,,CC(=O)O,O,val
US06090836,BrCCCBr.COC(=O)Cc1ccc(O)c(F)c1>>COC(=O)Cc1ccc(OCCCBr)c(F)c1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110183972A1,N#Cc1nc(Cl)ccc1N.Nc1ccccc1.O=N[O-]>>N#Cc1nc(Cl)ccc1NN=Nc1ccccc1,,CCO,O,Cl,,val
US20150218156A1,O=c1[nH]c(=O)n(CCc2ccccc2)nc1O>>O=c1[nH]c(=O)n(Cc2ccccc2)nc1O,,CO,,,,val
US20090069565A1,CC(C)(C)OC(=O)Cn1c(C(=O)OCc2ccccc2)cc2ccccc21>>CC(C)(C)OC(=O)Cn1c(C(=O)O)cc2ccccc21,,CCO,CN(C)C=O,,,val
US06350749B1,Cl.N=C(N)NN.O=C1CC(c2ccccc2)Cc2[nH]c3c(c21)CCCC3>>Cl.N=C(N)NN=C1CC(c2ccccc2)Cc2[nH]c3c(c21)CCCC3,,CCO,,Cl,O,val
US20040152699A1,CNC(=S)NN.O=C(Cl)c1ccco1>>Cn1c(S)nnc1-c1ccco1,,CCOC(C)=O,c1ccncc1,Cl,O=C([O-])O.[Na+],val
US20100016319A1,Cc1ccc(-n2nc(-c3ccco3)cc2NC(=O)NCc2ccccc2O)cc1.Clc1ccnc(Cl)n1>>Cc1ccc(-n2nc(-c3ccco3)cc2NC(=O)NCc2ccccc2Oc2ccnc(Cl)n2)cc1,,CC(C)=O,,[Na+].[OH-],,val
US20130158003A1,Cl.c1ccc2nc(CCc3nc4ccc5ncccc5n4n3)cnc2c1>>Cl.c1ccc2nc(CCc3nc4ccc5ncccc5n4n3)cnc2c1,,CO,,,,val
US20030229119A1,NC1CCC(Nc2ccnc3cc(Cl)ccc23)CC1.O=C=Nc1ccc(Cl)cc1>>O=C(Nc1ccc(Cl)cc1)N[C@@H]1CC[C@H](Nc2ccnc3cc(Cl)ccc23)CC1,,ClC(Cl)Cl,,,,val
US04589905,CCOC(=O)c1cnn(C(C)(C)C)c1C=NO>>CCOC(=O)c1cnn(C(C)(C)C)c1C#N,,CCOCC,,O,O=S(Cl)Cl,val
US20070060589A1,COC(=O)c1ccccc1-c1cccc(CNC(=O)C(C)NC(=O)OC(C)(C)C)c1>>CC(NC(=O)OC(C)(C)C)C(=O)NCc1cccc(-c2ccccc2C(=O)O)c1,,CO,,[Na+].[OH-],,val
US20040224997A1,CC(C)(C)OC(=O)[C@@H]1CCC[C@H]1C(=O)c1ccccc1Br.COC(=O)[C@@H]1CCC[C@H]1C(=O)c1ccc(-c2ccc(Nc3nc4ccc(OC(F)(F)F)cc4s3)c(F)c2)cc1.Fc1ccc2nc(Nc3ccc(Br)cc3F)sc2c1>>CC(C)(C)OC(=O)[C@@H]1CCC[C@H]1C(=O)c1ccc(-c2ccc(Nc3nc4ccc(F)cc4s3)c(F)c2)cc1.O=C(c1ccc(-c2ccc(Nc3nc4ccc(F)cc4s3)c(F)c2)cc1)[C@@H]1CCC[C@H]1C(=O)O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20120088755A1,COc1ccc2c(c1)CCN(C1CCNCC1)C(=O)N2.Cc1nc2cc(Oc3cc(Cl)ncn3)cc(Cl)c2[nH]1>>COc1ccc2c(c1)CCN(C1CCN(c3cc(Oc4cc(Cl)c5[nH]c(C)nc5c4)ncn3)CC1)C(=O)N2,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US04452799,O=C1CC2(CCCC2)CC(=O)N1CCCCBr.c1ccc2c(N3CCNCC3)nsc2c1>>O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2nsc3ccccc23)CC1,,CC#N,,[I-].[K+],,val
US20060241135A1,CC(C)Oc1cccc(C23CC(CC(N4C(=O)c5ccccc5C4=O)C2)N(CCCc2ccccc2)CC3C)c1>>CC(C)Oc1cccc(C23CC(N)CC(C2)N(CCCc2ccccc2)CC3C)c1,,CCO,,NN,,val
US04990495,CC(C)(C)COCCCC=CCCC=CCCCO>>CC(C)(C)COC1CCC=CCCC=CCCC1=O,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20130317026A1,COC(=O)c1cc(Br)cc2c1cnn2C1CCCC1>>O=C(O)c1cc(Br)cc2c1cnn2C1CCCC1,,CCO,,[Na+].[OH-],,val
US05202312,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.On1nnc2ccccc21>>COC(=O)c1[nH]cnc1CCNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C,,CCN(CC)CC,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20110257151A1,CC1(C)Cc2c(cc(F)cc2C(=O)O)NC1c1cccc(N2CCOCC2)c1.NS(=O)(=O)C1CC1>>CC1(C)Cc2c(cc(F)cc2C(=O)NS(=O)(=O)C2CC2)NC1c1cccc(N2CCOCC2)c1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20160159784A1,CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(Br)nc2)C2CC2)CC1.CC1(C)OB(c2cn[nH]c2)OC1(C)C>>CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3cn[nH]c3)nc2)C2CC2)CC1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20120149694A1,O=C(N1CCOCC1)N1CC(CS(=O)(=O)[O-])CC(c2ccc(C(F)(F)F)cc2)C1.OC1CCC1>>O=C(N1CCOCC1)N1CC(COC2CCC2)CC(c2ccc(C(F)(F)F)cc2)C1,,CN(C)C=O,,O,[H-].[Na+],val
US20070197571A1,CC(=O)OC(C)=O.CCOC(=O)C1(Nc2cccc(F)c2)CCN(Cc2ccccc2)CC1>>CCOC(=O)C1(N(C(C)=O)c2cccc(F)c2)CCN(Cc2ccccc2)CC1,,O,,[NH4+].[OH-],,val
US20030069278A1,CC(C)(C)OC(=O)N1CCC(O)C1.Oc1cccc2[nH]ccc12>>CC(C)(C)OC(=O)N1CCC(Oc2cccc3[nH]ccc23)C1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04469686,CC1(C)NC(P(=O)(O)O)C(C)(C)S1>>CC(C)(S)C(N)P(=O)(O)O,,O,,,,val
US20040067935A1,CC1(C)CCN(CCc2ccc(F)cc2)CC1CN.CCc1cc(NC(=O)Oc2ccccc2)cc(-c2nnnn2C)c1>>CCc1cc(NC(=O)NCC2CN(CCc3ccc(F)cc3)CCC2(C)C)cc(-c2nnnn2C)c1,,CN(C)C=O,,CCN(CC)CC,,val
US20100317659A1,Cc1ccc2c(O)nc(C(O)c3ccc(F)cc3)nc2c1>>Cc1ccc2c(O)nc(C(=O)c3ccc(F)cc3)nc2c1,,CC#N,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20020173507A1,CCO.CCc1cccc(NC(=O)Nc2csc(-c3ccnc(Cl)c3)n2)n1>>CCOc1cc(-c2nc(NC(=O)Nc3cccc(CC)n3)cs2)ccn1,,O,,C,C[O-].[Na+],val
US20090105253A1,CCCN.[N-]=[N+]=Nc1ccc(C(=O)O)cc1>>CCCNC(=O)c1ccc(N=[N+]=[N-])cc1,,CC#N,CN(C)C=O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20080146523A1,CCC(=O)c1ccccc1.CCOP(=O)(Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)OCC>>CCC(=Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)c1ccccc1,,C1CCOC1,CCOC(C)=O,CC(C)(C)[O-].[K+],,val
US04352811,CCC(C)=O.Fc1ccc2c(C3CCNCC3)noc2c1.O=S(=O)(CCCc1cc2ccccc2[nH]1)c1ccccc1>>Cc1[nH]c2ccccc2c1CCCN1CCC(c2noc3cc(F)ccc23)CC1,,O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20160207893A1,COC(=O)c1cc(OC)ncc1SCCNC(=O)OC(C)(C)C>>COC(=O)c1cc(OC)ncc1SCCN,,C1COCCO1,,Cl,,val
US20120142717A1,CC(=O)c1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1>>CC(O)c1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1,,CCO,,[BH4-].[Na+],,val
US20070179136A1,COC(=O)c1ccc(-c2cccn2C(=O)OC(C)(C)C)cc1F>>COC(=O)c1ccc(C2CCCN2C(=O)OC(C)(C)C)cc1F,[Pt],CC(=O)O,,,,val
US20040034089A1,CC(=O)Cl.NC(=O)C1Cc2cc(F)ccc2N1>>CC(=O)N1c2ccc(F)cc2CC1C(N)=O,,ClCCl,,CCN(CC)CC,O,val
US20090209607A1,Cn1nccc1B1OCC(C)(C)CO1.O=C(O)c1ccc(Br)s1>>Cn1nccc1-c1ccc(C(=O)O)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20080027080A1,CC(=O)N[C@@H]1C[C@H](N(C)C)CC[C@@H]1N1CC[C@H](NC(=O)OCc2ccccc2)C1=O>>CC(=O)N[C@@H]1C[C@H](N(C)C)CC[C@@H]1N1CC[C@H](N)C1=O,[Pd],CCOC(C)=O,,,,val
US20150111870A1,C[O-].Clc1cc(Cl)c2cc(Br)ccc2n1>>COc1cc(Cl)c2cc(Br)ccc2n1,,Cc1ccccc1,,O,,val
US20080045521A1,COC(=O)[C@H](Cc1ccc(OCC(C)c2ccc3c(n2)N(C(=O)OC(C)(C)C)CCC3)cc1)NC(=O)c1c(Cl)cccc1Cl>>COC(=O)[C@H](Cc1ccc(OCC(C)c2ccc3c(n2)NCCC3)cc1)NC(=O)c1c(Cl)cccc1Cl,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100184815A1,CC(Br)c1ccccc1.CCCn1c(COC(c2ccccc2)(c2ccccc2)c2ccccc2)n[nH]c1=O>>CCCn1c(COC(c2ccccc2)(c2ccccc2)c2ccccc2)nn(Cc2ccc(C)cc2)c1=O,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04983596,CS(=O)(=O)O[C@@H]1C[C@@H](COCCO)N(C(=O)OCc2ccccc2)C1>>CS(=O)(=O)O[C@@H]1C[C@@H](COCC=O)N(C(=O)OCc2ccccc2)C1,,CCN(CC)CC,ClCCl,CS(C)=O,O=C(Cl)C(=O)Cl,val
US20030092676A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.OCC1CCNc2ccccc21>>CC(C)(C)[Si](OCC1CCNc2ccccc21)(c1ccccc1)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20110152240A1,CN1C(=O)CNC1=O.N#Cc1ccc(Nc2cc(NC3CC3)n3ncc(C=O)c3n2)cc1>>CN1C(=O)N/C(=C\c2cnn3c(NC4CC4)cc(Nc4ccc(C#N)cc4)nc23)C1=O,,CCO,O,C1CCNCC1,,val
US04556737,COS(=O)(=O)c1ccc(C)cc1.CSCCOc1ccccc1OCC(O)CO>>C[S+](C)CCOc1ccccc1OCC(O)CO.Cc1ccc(S(=O)(=O)[O-])cc1,,CCOCC,,ClCCl,,val
US20130323880A1,CC(C)(C)OC(=O)Nc1ccc(B(O)O)cc1.Cc1ccc(Br)c(C)c1>>Cc1ccc(-c2ccc(NC(=O)OC(C)(C)C)cc2)c(C)c1,,Cc1ccccc1,,O,,val
US06362177B1,CC(C)(C)OC(=O)Nc1cc(F)c(F)cc1C(=O)NCC(=O)NCC1CCNCC1.Cc1ccc(C=O)cc1[N+](=O)[O-]>>Cc1ccc(CN2CCC(CNC(=O)CNC(=O)c3cc(F)c(F)cc3N)CC2)cc1[N+](=O)[O-],,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20110263582A1,C=CCC1(c2ccccc2)CCN([C@@H](C)C(C)(C)O[Si](C)(C)C(C)(C)C)C(=O)O1>>C=CCC1(c2ccccc2)CCN([C@@H](C)C(C)(C)O)C(=O)O1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080221107A1,O=C1C(Br)=CC(Br)(Br)C=C1Br.O[C@@H]1CCN(c2cccnc2)C1>>O[C@@H]1CCN(c2ccc(Br)nc2)C1,,ClCCl,,[Na+].[OH-],,val
US20140206681A1,COC[C@H]1CC[C@H](C(=O)NCc2nccnc2Cl)CN1C(=O)OCc1ccccc1>>COC[C@@H]1CC[C@@H](c2ncc3c(Cl)nccn23)CN1C(=O)OCc1ccccc1,,CC#N,,O=P(Cl)(Cl)Cl,O=C([O-])O.[Na+],val
US06028096,C=CCBr.N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1C(=O)C(F)(F)F>>C=CCNc1c(C(=O)C(F)(F)F)c(C#N)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20140200216A1,C[C@H]1CN(c2ccncc2N)C[C@@H](NC(=O)OC(C)(C)C)[C@H]1n1ccnn1.O=C(Nc1cc2ccc(Br)cc2nc1C(=O)O)OCc1ccccc1>>C[C@H]1CN(c2ccncc2NC(=O)c2nc3cc(Br)ccc3cc2NC(=O)OCc2ccccc2)C[C@@H](NC(=O)OC(C)(C)C)[C@H]1n1ccnn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030045540A1,C=C(C)CBr.OCc1cc(I)c(O)c(Cl)n1>>C=C(C)COc1c(I)cc(CO)nc1Cl,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20030229089A1,N#Cc1ncc(Br)cc1Br.O=S(=O)(O)O>>O=C(O)c1ncc(Br)cc1Br,,O,,CC(=O)O,,val
US20100137313A1,CCOC(=O)C(Br)C(=O)c1ccccc1.COCCCNc1nc(Nc2ccc(F)c(Cl)c2)ncc1C(N)=S>>CCOC(=O)c1sc(-c2cnc(Nc3ccc(F)c(Cl)c3)nc2NCCCOC)nc1-c1ccccc1,,CCO,,,,val
US06527959B1,C=O.O=C(O)c1ccccc1O>>C=O.O=C(O)c1ccccc1O,,O,,Cl,,val
US04981865,CN(C)C=O.O=C(O)c1ccccc1Nc1c(Cl)cccc1Cl>>COC(=O)c1ccccc1Nc1c(Cl)cccc1Cl,,C1CCOC1,,O=C(Cl)C(=O)Cl,,val
US05593984,Cc1nccn2c(Br)ccc12.N#C[Cu]>>Cc1nccn2c(C#N)ccc12,,CN1CCCC1=O,,[C-]#N.[Na+],,val
US20160068513A1,Nc1nccs1.O=C1O[C@H]2C[C@@H]1N(c1nc3c(c(Nc4cc(C5CC5)[nH]n4)n1)CCC3)C2>>O=C(Nc1nccs1)[C@@H]1C[C@H](O)CN1c1nc2c(c(Nc3cc(C4CC4)[nH]n3)n1)CCC2,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20050272779A1,CCOC(=N)c1ccc(OC)cc1.NC1CC1>>COc1ccc(C(=N)NC2CC2)cc1,,ClCCl,,Cl,,val
US20100249191A1,N#Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1-n1cccn1.O=C1CCC(=O)N1Cl>>N#Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1-n1cc(Cl)cn1,,CN(C)C=O,,CCOC(C)=O,O,val
US20120046304A1,CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)cc1)OC31CCCC1)[C@@H](O)CC(C)(C)[C@H]2CC(=O)[O-].CO>>CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)cc1)OC31CCCC1)[C@@H](O)CC(C)(C)[C@H]2O,O,CO,,O=C([O-])[O-].[K+].[K+],,val
US20140243349A1,COc1ccc(B(O)O)c2c1OCCO2.OO>>COc1ccc(O)c2c1OCCO2,,C1CCOC1,O,[Na+].[OH-],,val
US20110256128A1,CC(C)(C)OC(=O)N[C@@H](C(=O)O)C(C)(C)C.N=C(NN)c1cc(F)ccc1F>>CC(C)(C)OC(=O)N[C@@H](C(=O)NNC(=N)c1cc(F)ccc1F)C(C)(C)C,,C1CCOC1,,CCN(CC)CC,CCOC(=O)Cl,val
US20140056849A1,CC(C)(C)OC(=O)NCC(=O)OCCl.CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2cn(COC(=O)CN)c3ncc(-c4ccc(Cl)cc4)cc23)c1F.Cl,,CN(C)C=O,,[K+].[OH-],,val
US05205914,COC(=O)C(F)(OC)C(F)(F)F>>COC(F)(C(=O)O)C(F)(F)F,,O,,Cl,[K+].[OH-],val
US20050070549A1,CC(C)CN(Cc1ccc(Cl)cc1)C1CCN(C(=O)OC(C)(C)C)C1>>CC(C)CN(Cc1ccc(Cl)cc1)C1CCNC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090023789A1,COC(=O)c1cc(C#N)ccc1O.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>COC(=O)c1cc(C#N)ccc1OCC(F)(F)F,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06015821,CCCCC/C=C\C/C=C\C/C=C\CCCCCO.O=C(Cl)CCl>>CCCCC/C=C\C/C=C\C/C=C\CCCCCOC(=O)CCl,,ClCCl,,CCN(CC)CC,,val
US20090156594A1,BrBr.CC(=O)Oc1ccc2ncccc2c1>>CC(=O)Oc1ccc2ncc(Br)cc2c1,,ClC(Cl)(Cl)Cl,,c1ccncc1,,val
US20050277652A1,Nc1cc(Oc2ccc(N)c(Cl)c2)ccn1.O=C(Cl)Oc1ccccc1>>Nc1ccc(Oc2ccnc(NC(=O)Oc3ccccc3)c2)cc1Cl,,C1CCOC1,,CCN(CC)CC,,val
US20140045862A1,COCCl.O[C@@H]1CCCC[C@H]1c1cn[nH]c1>>COCn1cc([C@@H]2CCCC[C@H]2O)cn1,,CN(C)C=O,,,,val
US20050014952A1,CCO.Cl.N#Cc1cccc(Cl)c1>>CCOC(=N)c1cccc(Cl)c1.Cl,,CCOCC,Cl,O=S(=O)(O)O,,val
US20090130076A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1nc2c(Br)cc(CO)cc2s1>>CC(C)(C)OC(=O)Nc1nc2c(Br)cc(CO)cc2s1,,C1CCOC1,,CO,[Na+].[OH-],val
US20020165229A1,CC#CC(=O)O.N#Cc1cnc2ncc(N)cc2c1Nc1cccc(Br)c1>>CC#CC(=O)Nc1cnc2ncc(C#N)c(Nc3cccc(Br)c3)c2c1,,C1CCOC1,c1ccncc1,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20020099212A1,CC(=O)c1ccc(Cl)cc1Cl.C[Si](C)(C)Cl>>C=C(O[Si](C)(C)C)c1ccc(Cl)cc1Cl,,C1CCOC1,CN(C)P(=O)(N(C)C)N(C)C,CC(C)NC(C)C,[Li]CCCC,val
US20060106027A1,O=[N+]([O-])c1ccc(OCCCl)cc1>>Nc1ccc(OCCCl)cc1,O=[Pt]=O,CCO,ClCCl,,,val
US05202407,COc1cccc(CCl)c1.Cc1ccc(P(c2ccc(C)cc2)c2ccc(C)cc2)cc1>>COc1cccc(C[P+](c2ccc(C)cc2)(c2ccc(C)cc2)c2ccc(C)cc2)c1.[Cl-],,Cc1ccccc1,,O=P(O)(O)O,,val
US20150336949A1,Cc1n[nH]c(C)c1B1OC(C)(C)C(C)(C)O1.Fc1cccc(CBr)c1>>Cc1nn(Cc2cccc(F)c2)c(C)c1B1OC(C)(C)C(C)(C)O1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100234365A1,CC(C)(C)OC(=O)N[C@H](CC1C(=O)OC(C)(C)OC1=O)c1cccc(C(F)(F)F)c1>>CC(C)(C)OC(=O)N1C(=O)C(C(=O)O)C[C@@H]1c1cccc(C(F)(F)F)c1,,Cc1ccccc1,,,,val
US20090281086A1,CC(C)(C)OC(=O)N1CCNCC1.CC(O)c1ccc(F)c(C(=O)O)c1>>CC(O)c1ccc(F)c(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1,,ClCCl,,CCN(CC)CC,,val
US06713471B1,CC(C)(C)OC(=O)N1CCC2C(C1)c1cccc3c1N2CCS3.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCC2C(C1)c1cc(Br)cc3c1N2CCS3,,CN(C)C=O,,,,val
US20070027178A1,Cl.Nc1cccc(Br)c1SCCCCl.O=N[O-]>>Cl.NNc1cccc(Br)c1SCCCCl,,O,,Cl[Sn]Cl,,val
US05034153,C=CCCCCCCCCO.O=S(Cl)Cl>>CCCCCCCCC=CCl,c1ccncc1,ClCCl,,,,val
US20080027112A1,CCOC(=O)CN.COc1ccc2c(Cl)cc(=O)oc2c1OC1CCCC1>>CCOC(=O)CNc1cc(=O)oc2c(OC3CCCC3)c(OC)ccc12,,CCO,,CCN(CC)CC,Cl,val
US20130029968A1,CCc1cc(OC)c(F)cc1-c1ccc2cn[nH]c2c1.II>>CCc1cc(OC)c(F)cc1-c1ccc2c(I)n[nH]c2c1,,CN(C)C=O,O,[K+].[OH-],,val
US20080319188A1,CC(C)(C)OC(=O)N1CCC(N2CCN(C(=O)OCc3ccccc3)CC2)CC1>>O=C(OCc1ccccc1)N1CCN(C2CCNCC2)CC1,,O=C(O)C(F)(F)F,,[Na+].[OH-],,val
US20090163520A1,CC(C)(C)OC(=O)N(N)c1ccc(-n2cccc2)cc1.Cl>>Cl.NNc1ccc(-n2cccc2)cc1,,ClCCl,,C1COCCO1,,val
US20130317021A1,O=C(NCCc1ccc(Cl)cc1)c1cc([N+](=O)[O-])[nH]n1>>Nc1cc(C(=O)NCCc2ccc(Cl)cc2)n[nH]1,[Fe],C1CCOC1,CCO,[Cl-].[NH4+],,val
US20140163012A1,CN1CCCc2oc3cc(N4CCN(CCc5ccc(F)cn5)CC4=O)ccc3c2C1.Cl>>CN1CCCc2oc3cc(N4CCN(CCc5ccc(F)cn5)CC4=O)ccc3c2C1.Cl,,CO,,CCOCC,,val
US20070208166A1,CCCCCOc1ccc(C(=O)Cl)cc1.NCC(=O)NC1CCCc2ccccc21>>CCCCCOc1ccc(C(=O)NCC(=O)NC2CCCc3ccccc32)cc1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20070213371A1,CCI.Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)ccc2C(O)C2CCC2)n1>>CCOC(c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1)C1CCC1,,C1CCOC1,,[H-].[Na+],,val
US20110207654A1,CSCC[C@@H](N)C(=O)O.O=C1OC(=O)c2ccccc21>>CSCC[C@H](C(=O)O)N1C(=O)c2ccccc2C1=O,,Cc1ccccc1,,CCN(CC)CC,,val
US20150291526A1,CCOC(=O)c1c(CC(C)C)[nH]c(=O)c(-c2ccccc2)c1O>>CC(C)Cc1[nH]c(=O)c(-c2ccccc2)c(O)c1C(=O)O,,[Na+],[OH-],Cl,,val
US20150307454A1,FC(F)(F)Oc1ccc(CBr)cc1.N#Cc1ccc(S(=O)(=O)Nc2ncc3ccccc3c2C2CC2)cc1>>N#Cc1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2C2CC2)cc1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20020193614A1,CCOC(=O)c1ccc(CNC(=O)c2cc([N+](=O)[O-])ccc2NC2CCCC2)cc1>>O=C(O)c1ccc(CNC(=O)c2cc([N+](=O)[O-])ccc2NC2CCCC2)cc1,,CCO,,Cl,[Na+].[OH-],val
US20030158198A1,Cc1cc2c(N)cccc2c(C)n1.O=C=NCc1ccc(Br)cc1>>Cc1cc2c(NC(=O)NCc3ccc(Br)cc3)cccc2c(C)n1,,Cc1ccccc1,,,,val
US20070117839A1,C=CCC(=O)N1[C@@H](/C=C/C(=O)OCC)CC[C@H]1c1c(F)cc(F)cc1F>>O=C1CC=C[C@H]2CC[C@@H](c3c(F)cc(F)cc3F)N12,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,ClCCl,,CCN(CC)CC,,val
US20090042892A1,COc1ccc(C2=CCC3(CC2)OCCO3)cc1>>COc1ccc(C2CCC3(CC2)OCCO3)cc1,[Pd],CCO,,,,val
US04088695,CCCCCC(C)(O)C=CC1CCC2(OCCO2)C1CCCCCCCO[Si](C)(C)C>>CCCCCC(C)(O)C=CC1CCC(=O)C1CCCCCCCO,,C1COCCO1,CC(=O)O,Cc1ccccc1,O,val
US20120157438A1,COC(=O)c1cc(Br)c2ccccc2c1N>>Nc1c(C(=O)O)cc(Br)c2ccccc12,,C1CCOC1,,Br,[Na+].[OH-],val
US20100311966A1,CCOC(=O)c1sc(N2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)[C@H](OCC)C2)nc1C(=O)NCCF>>CCO[C@@H]1CN(c2nc(C(=O)NCCF)c(C(=O)O)s2)CC[C@@H]1NC(=O)c1nc(Cl)c(CC)[nH]1,,CO,,[Li+].[OH-],,val
US20030165561A1,C#Cc1cccc(NC(=O)C(Cl)Cl)c1.ON=C(Cl)c1c(Cl)cccc1Cl>>O=C(Nc1cccc(-c2cc(-c3c(Cl)cccc3Cl)no2)c1)C(Cl)Cl,,C1CCOC1,CCN(CC)CC,,,val
US05312828,CCCCc1ncc(C=O)n1Cc1ccccc1Cl.CCOC(=O)C(C)P(=O)(OCC)OCC>>CCCCc1ncc(/C=C(\C)C(=O)OCC)n1Cc1ccccc1Cl,,CCO,,[Na],,val
US06291482B1,C=CC=O.O=Cc1cc(Cc2cccnc2)ccc1O>>O=CC1=Cc2cc(Cc3cccnc3)ccc2OC1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20150191483A1,COCC1(C(=O)OC)CCC(C(=O)OC)CC1>>COCC1(C(=O)O)CCC(C(=O)O)CC1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20110190280A1,CCC(N)=S.O=C(Cc1ccnc(Cl)n1)c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1>>CCc1nc(-c2ccc3ccn(S(=O)(=O)c4ccccc4)c3c2)c(-c2ccnc(Cl)n2)s1,,ClCCl,,O=C1CCC(=O)N1Br,,val
US05109014,O=C(Nc1ccc(C(F)(F)F)cc1)N1CC(c2ccccc2)C(c2ccc(Cl)cc2)=N1>>O=C(Nc1ccc(C(F)(F)F)cc1)N1CC(c2ccccc2)C(c2ccc(Cl)cc2)N1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US04698094,CCOC(=O)CS.O=C(Cl)Cc1cccc(Oc2ccc(C(F)(F)F)cc2Cl)c1>>CCOC(=O)CSC(=O)Cc1cccc(Oc2ccc(C(F)(F)F)cc2Cl)c1,,CC(=O)N(C)C,,CCN(CC)CC,O,val
US20090105253A1,CCNC(=O)c1ccc(-n2nnc(C(=O)NC3CC3)c2C)c(O)c1.FCCCCCBr>>CCNC(=O)c1ccc(-n2nnc(C(=O)NC3CC3)c2C)c(OCCCCCF)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120177681A1,CCOCc1nc2c(N)nc3ccccc3c2n1CCOCCOCCOCCP(=O)(OCC)OCC>>CCOCc1nc2c(N)nc3ccccc3c2n1CCOCCOCCOCCP(=O)(O)O,,ClCCl,,C[Si](C)(C)Br,,val
US20160168126A1,CC1=C(Cl)COC1=O.O=C1CCC(=O)N1Br>>CC1=C(Cl)C(Br)OC1=O,,ClC(Cl)(Cl)Cl,,,,val
US05885990,Cl.Cl.N=C(N)c1ccc2c(CC(N)=O)c(O)ccc2c1.O=C(O)c1ccc(NC=NNCCO)cc1>>Cl.Cl.N=C(N)c1ccc2c(CC(N)=O)c(OC(=O)c3ccc(NC=NNCCO)cc3)ccc2c1,CN(C)c1ccncc1,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100144717A1,CC(C)(C)OC(=O)N1CC[C@H](N(Cc2ccccc2)C(=O)OCc2ccccc2)[C@H](F)C1>>O=C(OCc1ccccc1)N(Cc1ccccc1)[C@H]1CCNC[C@H]1F,,C1COCCO1,ClCCl,Cl,,val
US04716159,C1CCNC1.c1ccc(-c2cc3ncc4ccccc4c3nn2)cc1>>c1ccc(-c2cc3nc(N4CCCC4)c4ccccc4c3nn2)cc1,,COCCOC,,,,val
US20090118296A1,Nc1ccccc1S.O=C(Cl)c1ccc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)nn1>>O=C(c1ccccc1C(F)(F)F)N1CCN(c2ccc(-c3nc4ccccc4s3)nn2)CC1,,CN1CCCC1=O,,,,val
US04472433,O=C1Cc2cccc(Oc3c(Cl)cccc3Cl)c2N1.[Na+].[OH-]>>Nc1c(CC(=O)[O-])cccc1Oc1c(Cl)cccc1Cl.[Na+],,C1COCCO1,,O,,val
US20100093730A1,Fc1ccc(C(c2ccccc2)N2CCNCC2)cc1.O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O>>O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)N1CCN(C(c2ccccc2)c2ccc(F)cc2)CC1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20090186879A1,O=[N+]([O-])c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl>>Nc1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl,[Pd],CC(=O)O,,,,val
US20100120764A1,CNCC1CCOCC1.O=C(Cl)c1ccc2nonc2c1>>CN(CC1CCOCC1)C(=O)c1ccc2nonc2c1,,ClCCl,,CCN(CC)CC,,val
US20070254925A1,O=C(Nc1nc(CO)c(-c2cccc(C(F)(F)F)c2)s1)c1c(F)cccc1F>>O=Cc1nc(NC(=O)c2c(F)cccc2F)sc1-c1cccc(C(F)(F)F)c1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20130183269A1,COC(=O)C1(COCc2ccccc2)CCCO1>>COC(=O)C1(CO)CCCO1,[Pd],CO,,,,val
US20090181964A1,Nc1c(C(=O)O)cccc1[N+](=O)[O-].c1ccc(COC(=NC2CCCCC2)NC2CCCCC2)cc1>>Nc1c(C(=O)OCc2ccccc2)cccc1[N+](=O)[O-],,CCCCCC,CCOC(C)=O,CN(C)C=O,,val
US20080293687A1,CCNCCOCc1cnc(-c2ccc(C(=O)Nc3ccccc3NC(=O)OC(C)(C)C)cc2)c(C#N)c1>>CCNCCOCc1cnc(-c2ccc(C(=O)Nc3ccccc3N)cc2)c(C#N)c1,,C1COCCO1,,Cl,,val
US20060014777A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1ccccc1[C@@H]1CN(Cc2ccccc2)C[C@H]1C(=O)OCc1ccccc1>>CCOC(=O)c1ccccc1[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1C(=O)O,[Pd],CO,,[H][H],,val
US20120088750A1,CCOC(=O)C1(O)CCNCC1.Clc1ncc(Br)cn1>>CCOC(=O)C1(O)CCN(c2ncc(Br)cn2)CC1,,CCO,,CCN(C(C)C)C(C)C,O,val
US04634692,CCOC(C)OC(C)(C)[C@@H](F)CC[C@@H](COS(=O)(=O)c1ccc(C)cc1)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC5CCCCO5)C[C@H](OC5CCCCO5)[C@]4(C)[C@H]3CC[C@]12C>>CCOC(C)OC(C)(C)[C@@H](F)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC5CCCCO5)C[C@H](OC5CCCCO5)[C@]4(C)[C@H]3CC[C@]12C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04772600,CN(C)CCNC(=O)Cn1c(-c2ccc(C(F)(F)F)cc2)nc2cccnc21.Cl>>CN(C)CCNC(=O)Cn1c(-c2ccc(C(F)(F)F)cc2)nc2cccnc21.Cl,,CC(C)O,,,,val
US07750161B2,Cc1cc(N)cc(C)n1.O=C(Oc1c(F)c(F)c(F)c(F)c1F)Oc1c(F)c(F)c(F)c(F)c1F>>Cc1cc(NC(=O)Oc2c(F)c(F)c(F)c(F)c2F)cc(C)n1,,C1CCOC1,,,,val
US20100179322A1,BrB(Br)Br.COc1ccc2ccn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)c2c1>>Br.O=c1c2cc(O)ccc2ccn1CCCCN1CCN(c2cccc3sccc23)CC1,,O,,ClCCl,,val
US05998433,CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc(C(=O)c3cccc(Cl)c3Cl)cc1)CC2.Cl>>CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc(C(=O)c3cccc(Cl)c3Cl)cc1)CC2.Cl,,CCOC(C)=O,CO,,,val
US20080051418A1,CC(C)O.O=C(O)c1ccc(Cl)nc1Cl>>CC(C)Oc1ccc(C(=O)O)c(Cl)n1,,CC(C)O,,CC(C)(C)[O-].[K+],,val
US20120108583A1,Nc1ccc(C(F)(F)F)cn1.OO>>Nc1ccc(C(F)(F)F)c[n+]1[O-],,CC(=O)O,,,,val
US04936892,CC(=O)O.Nc1ccnn1-c1c(F)cc(C(F)(F)F)cc1Cl>>CC(=O)Nc1ccnn1-c1c(F)cc(C(F)(F)F)cc1Cl,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20130012513A1,Cc1nc(-c2ccc(N)cc2)cs1.O=C(O)c1ccc(Cl)cc1Cl>>Cc1nc(-c2ccc(NC(=O)c3ccc(Cl)cc3Cl)cc2)cs1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090234001A1,CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1ccc2ccc(C(=O)OC)cc2c1>>CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1ccc2ccc(C(=O)O)cc2c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20030226216A1,COc1ccc([N+](=O)[O-])c(N2CCCC2)n1>>COc1ccc(N)c(N2CCCC2)n1,[Pd],CCO,,,,val
US20090312321A1,CCNc1nc(SC)ncc1C=O.COC(=O)c1cc(CC#N)cc(OC)c1>>CCn1c(=N)c(-c2cc(OC)cc(C(=O)OC)c2)cc2cnc(SC)nc21,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20120245341A1,COc1ccc(C(OCc2cccc(CNC(=S)NCc3cccc(CO[Si](C)(C)C(C)(C)C)n3)c2)(c2ccccc2)c2ccc(OC)cc2)cc1>>COc1ccc(C(OCc2cccc(CNC(=S)NCc3cccc(CO)n3)c2)(c2ccccc2)c2ccc(OC)cc2)cc1,,C1CCOC1,,,,val
US20080045528A1,CN.O=C(Cl)c1cnccc1Cl>>CNC(=O)c1cnccc1Cl,,C1CCOC1,,Cl,,val
US20050245563A1,COC(=O)CC(C)=O.COC(=O)c1cc(F)ccc1N>>COC(=O)c1cc(F)ccc1NC(=O)CC(C)=O,,Cc1ccccc1,,,,val
US05912261,O=C(O)CN1C(=O)C(=O)N(Cc2cccc([N+](=O)[O-])c2)C1=S.O=C([O-])CN1CC(=O)NC1=O>>O=C(O)CN1CC(=O)N(Cc2cccc([N+](=O)[O-])c2)C1=O,,CC(=O)O,,Cl,,val
US20100286123A1,CC(C)(C)OC(=O)CC(=O)OC(C)(C)C.N#Cc1cc(Cl)c(F)cc1F>>CC(C)(C)OC(=O)C(C(=O)OC(C)(C)C)c1cc(F)c(C#N)cc1Cl,,CCOCC,CN(C)C=O,[H][H],[H-].[Na+],val
US05849755,COc1ccc(Cl)cc1C(=O)Cl.COc1ccc2c(c1)OCC(N)C2>>COc1ccc2c(c1)OCC(NC(=O)c1cc(Cl)ccc1OC)C2,,c1ccncc1,,Cl,,val
US20080045626A1,C=C(C)C(=O)OC(=O)C(=C)C.C=CCOCC(CO)OCC=C>>C=CCOCC(COCC=C)OC(=O)C(=C)C,CN(C)c1ccncc1,,,C1CCOC1,CCN(CC)CC,val
US06479531B1,O=C(O)CCl.OCC12CC3CC(CC(C3)C1)C2>>O=C(O)COCC12CC3CC(CC(C3)C1)C2,,CN(C)C=O,,O,[H-].[Na+],val
US20050124646A1,C=CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O[Si](C)(C)C(C)(C)C)C(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC.CC(=O)OC(C)=O>>C=CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O[Si](C)(C)C(C)(C)C)C(OC)C3)C(C)C(OC(C)=O)CC1=O)C(C)CC2OC,,c1ccncc1,,,,val
US05250554,CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,ClCCl,,CCN(CC)CC,,val
US04517187,CCOC(=O)C(=O)[O-].CNC[C@@H]1NC[C@@H](c2ccccc2)c2ccccc21>>CN1C[C@@H]2c3ccccc3[C@H](c3ccccc3)CN2C(=O)C1=O,,CCN(CC)CC,,Cl,Cl,val
US04166131,CCC1(C)Cc2cc(Cl)c(CC(=O)OC)cc2C1>>CCC1(C)Cc2cc(Cl)c(CC(=O)O)cc2C1,,CO,O,[K+].[OH-],,val
US04382942,BrB(Br)Br.CCCN1CCC=C(c2ccc(OC)c(OC)c2)C1>>Br.CCCN1CCC=C(c2ccc(O)c(O)c2)C1,,ClCCl,,O,,val
US04644061,CC(=O)OC(C)=O.Cc1cc[n+]([O-])cc1C>>CC(=O)OCc1ccncc1C,,O,,,,val
US20050197351A1,COC(=O)C=Cc1ccccc1N.O=C=Nc1ccccc1>>COC(=O)C=Cc1ccccc1NC(=O)Nc1ccccc1,,c1ccccc1,,,,val
US20080214553A1,CN(C)Cc1cccc(B2OC(C)(C)C(C)(C)O2)c1.COc1cccc(-c2nc3cc(Cl)ccc3c(=O)n2CC(=O)NC(C)C)c1>>COc1cccc(-c2nc3cc(-c4cccc(CN(C)C)c4)ccc3c(=O)n2CC(=O)NC(C)C)c1,,CN(C)C=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20150065507A1,CC(C)c1ccc(N(CC2COC2)S(=O)(=O)c2ccc(F)cc2)nc1.OCC1CCOCC1>>CC(C)c1ccc(N(CC2COC2)S(=O)(=O)c2ccc(OCC3CCOCC3)cc2)nc1,,CS(C)=O,,[H-].[Na+],,val
US06245773B1,CC(C)(C)OC(=O)N(CCCl)CCCl.N#CCc1ccc(F)cc1F>>CC(C)(C)OC(=O)N1CCC(C#N)(c2ccc(F)cc2F)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20140323477A1,CCNS(=O)(=O)c1ccc(-c2cc3cnc(SC)nc3n(CC)c2=O)c(C)c1.O=C(OO)c1cccc(Cl)c1>>CCNS(=O)(=O)c1ccc(-c2cc3cnc(S(C)=O)nc3n(CC)c2=O)c(C)c1,,ClCCl,,,,val
US20050187228A1,NCCNc1nc(Cl)nc2c1ncn2C1CCCC1.O=C(Cl)c1ccc(F)cc1>>O=C(NCCNc1nc(Cl)nc2c1ncn2C1CCCC1)c1ccc(F)cc1,,CCOCC,,CCN(CC)CC,ClCCl,val
US20090198063A1,CCOC(=O)/C=C/c1ncc(OC)nc1N>>COc1cnc2ccc(=O)[nH]c2n1,,CCO,,CO,C[O-].[Na+],val
US20100331293A1,COC(=O)Cl.Cc1c(N2CCNCC2)nc2cc(F)cc(F)c2c1Cl>>COC(=O)N1CCN(c2nc3cc(F)cc(F)c3c(Cl)c2C)CC1,,CC(C)=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20160194315A1,COC(=O)c1ccnc(C#CC(C)(C)O)c1N>>COC(=O)c1ccnc2cc(C(C)(C)O)[nH]c12,[Cu]I,CN(C)C=O,,N#N,,val
US20100004331A1,CCOC(=O)Cc1ccc(OC)c(Oc2ccc([N+](=O)[O-])cc2CSCC(F)(F)F)c1>>O=C(O)Cc1ccc(O)c(Oc2ccc([N+](=O)[O-])cc2CSCC(F)(F)F)c1,,CC(=O)O,,Br,,val
US20100216836A1,O=C([C@H]1COc2ccccc2O1)N1CCC[C@H](c2cccc(O)c2)C1>>Oc1cccc([C@H]2CCCN(C[C@H]3COc4ccccc4O3)C2)c1,,C1CCOC1,,,,val
US20160096827A1,CC(C)(O)c1cc(Nc2ncnc(Cl)n2)ccn1.C[C@H](O)C(=O)N1CC[C@H](Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2C#N)[C@H](F)C1>>C[C@H](O)C(=O)N1CC[C@H](Oc2ccc(-c3ncnc(Nc4ccnc(C(C)(C)O)c4)n3)cc2C#N)[C@H](F)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20100216814A1,COc1ccc(C(C)(O)Cn2c3c(c4cc(Cl)ccc42)CN(C)CC3)cc1>>COc1ccc(/C(C)=C/n2c3c(c4cc(Cl)ccc42)CN(C)CC3)cc1,,O,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20130281490A1,C[C@@H](O)[C@H](N)C(=O)O.O=C([O-])n1cccc(CCCCCc2ccccc2)c1=O>>C[C@@H](O)[C@H](NC(=O)OCCCCCc1ccccc1)C(=O)O,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20040254159A1,CC(C)(C)OC(=O)Nc1ccc(C(=O)O)cc1I>>CC(C)(C)OC(=O)Nc1ccc(CO)cc1I,,C1CCOC1,,B,,val
US20120225909A1,CCOC(=O)CP(=O)(OCC)OCC.O=Cc1nn(C2CCCCO2)c2cc(OCc3ccccc3)ccc12>>CCOC(=O)/C=C/c1nn(C2CCCCO2)c2cc(OCc3ccccc3)ccc12,,C1CCOC1,CCOC(C)=O,O,[H-].[Na+],val
US20120190665A1,COc1ccc(Cl)cc1-c1nn(CC(=O)OC(C)(C)C)cc1NC(=O)c1cnn2cccnc12>>COc1ccc(Cl)cc1-c1nn(CC(=O)O)cc1NC(=O)c1cnn2cccnc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150232463A1,C1CC(C2CC2)CN1.Cc1nc(C)c(C(=O)C(=O)OC(C)C)c(Cl)c1Br>>Cc1nc(C)c(C(=O)C(=O)OC(C)C)c(N2CCC(C3CC3)C2)c1Br,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080171734A1,C1CNC1.O=C(O)c1cnc(Cl)cn1>>O=C(c1cnc(Cl)cn1)N1CCC1,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20090143229A1,CCOC(=S)[S-].Cc1nn(-c2cc(N)c(Br)cc2F)c(=O)n1C>>Cc1nn(-c2cc3nc(S)sc3cc2F)c(=O)n1C,,CN(C)C=O,,Cl,,val
US20130053565A1,CC(C)(C)OC(=O)N1CC(=O)C1.C[Si](C)(C)C#Cc1ccsc1>>CC(C)(C)OC(=O)N1CC(=O)C([Si](C)(C)C)=C(c2ccsc2)C1,,Cc1ccccc1,,,,val
US05344843,CCC(C)(C)C(=O)OCc1cccc(C)c1OCCOc1ccc(C(=O)C(=O)O)cc1>>Cc1cccc(CO)c1OCCOc1ccc(C(=O)C(=O)O)cc1,,CO,,Cl,[Na+].[OH-],val
US20070225324A1,NC(=O)[C@@H](c1ccccc1)n1ccc2c([N+](=O)[O-])cccc2c1=O>>NC(=O)[C@@H](c1ccccc1)n1ccc2c(N)cccc2c1=O,[Pd],,,CO,,val
US20060194843A1,CC(C)(C)OC(=O)N1CCC(NC(=O)c2n[nH]cc2[N+](=O)[O-])CC1>>CC(C)(C)OC(=O)N1CCC(NC(=O)c2n[nH]cc2N)CC1,[Pd],CCO,CN(C)C=O,,,val
US20110098320A1,C=CC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)C(=O)C1.Cn1cc(Br)ccc1=O>>C=CC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(-c3ccc(=O)n(C)c3)cc2)C(=O)C1,,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05157041,CC(C)(C)OC(=O)[C@@H]1CCCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(N)=O.O=C=NCc1ccccc1>>CC(C)(C)OC(=O)[C@@H]1CCCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)NCc1ccccc1,,ClCCl,,,,val
US20120040985A1,COc1cc(C(C)(C)C(=O)NNC(=S)Nc2ccc(F)cc2)ccc1Cl>>COc1cc(C(C)(C)c2nnc(S)n2-c2ccc(F)cc2)ccc1Cl,,[Na+],[OH-],Cl,,val
US20160016962A1,CI.COc1ccnc(-c2nnc3n2C[C@H](C)NC3=S)c1>>COc1ccnc(-c2nnc3n2C[C@H](C)N=C3SC)c1,,ClCCl,,,,val
US20070179191A1,C1=COCCC1.CCOC(=O)c1nc(-c2ccc(OC)cc2)oc1CO>>CCOC(=O)c1nc(-c2ccc(OC)cc2)oc1COC1CCCCO1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20150166564A1,Cc1c(OC[C@H]2COC(C)(C)O2)nn(-c2ccccc2)c1NC(=O)N[C@H]1CN(CC(F)(F)F)C[C@@H]1c1ccccc1>>Cc1c(OC[C@H](O)CO)nn(-c2ccccc2)c1NC(=O)N[C@H]1CN(CC(F)(F)F)C[C@@H]1c1ccccc1,,CC(C)O,,CCN(C(C)C)C(C)C,Cl,val
US04439433,On1nnc2ccccc21.[N-]=[N+]=NCCON=C(C(=O)O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>On1nnc2ccccc21.[N-]=[N+]=NCCON=C(C(=O)O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20040019058A1,Cn1c(CN(CCCCN2C(=O)c3ccccc3C2=O)C2CCCc3cccnc32)nc2ccccc21>>Cn1c(CN(CCCCN)C2CCCc3cccnc32)nc2ccccc21,,CCO,,NN,O,val
US20070117854A1,COC(=O)c1cnn(CO)c1.O=S(Cl)Cl>>COC(=O)c1cnn(CCl)c1,,ClCCl,,,,val
US20090075968A1,CN(C)C=O.Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)cnc2CCNC[C@@H]2CC[C@@H](CC(=O)O)CC2)n1>>Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)cnc2CCNC[C@@H]2CC[C@@H](CC(N)=O)CC2)n1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20090099207A1,CC(C)(C)c1cccc(C2(N3C(=O)O[C@@H]4[C@H](Cc5ccc(Br)cc5)CS(=O)(=O)C[C@@H]43)CC2)c1>>CC(C)(C)c1cccc(C2(N[C@H]3CS(=O)(=O)C[C@@H](Cc4ccc(Br)cc4)[C@H]3O)CC2)c1,,CCCCCC,CCOC(C)=O,,,val
US20060211720A1,CCOc1cc(OC(C)C)c(F)c(C(Nc2ccc(-c3noc(C)n3)cc2)c2nc(-c3ccccc3C(C)=O)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1>>CCOc1cc(OC(C)C)c(F)c(C(Nc2ccc(-c3noc(C)n3)cc2)c2nc(-c3ccccc3C(C)O)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1,,CO,,[BH4-].[Na+],,val
US20120100188A1,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O.O=C(O)C(=O)O>>Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O.O=C([O-])C(=O)[O-],,CCO,,,,val
US20100216746A1,CCOC(=O)c1cc2cc(OCC[C@H]3COC(C)(C)O3)ccc2n1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)n1c(C(=O)O)cc2cc(OCC[C@H]3COC(C)(C)O3)ccc21,,CO,,C1CCOC1,[Li+].[OH-],val
US20130203727A1,CC(C)[Si](Cl)(C(C)C)C(C)C.Cc1cc2cc(O)ccc2c(-c2ccc(Cl)cc2)c1Br>>Cc1cc2cc(O[Si](C(C)C)(C(C)C)C(C)C)ccc2c(-c2ccc(Cl)cc2)c1Br,CN(C)c1ccncc1,ClCCl,,C1CCC2=NCCCN2CC1,,val
US20140323474A1,Cc1coc([C@H]2C[C@H]3CSC(NC(=O)c4ccccc4)=N[C@@]3(c3cc(C#N)ccc3F)CO2)n1>>Cc1coc([C@H]2C[C@H]3CSC(N)=N[C@@]3(c3cc(C#N)ccc3F)CO2)n1,,CCO,,CN,,val
US06057369,COc1ccc(SC(CCCCc2ccccc2)C(C)C(=O)O)cc1.C[Si](C)(C)ON>>COc1ccc(SC(CCCCc2ccccc2)C(C)C(=O)NO)cc1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20120252853A1,CCOC(=O)c1cc(CCO[Si](C)(C)C(C)(C)C)no1>>CCOC(=O)c1cc(CCO)no1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20020120072A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.FC(F)(F)c1cc(Br)cc(N2CCNCC2)c1>>CC(C)(C)OC(=O)N1CCN(c2cc(Br)cc(C(F)(F)F)c2)CC1,,C1CCOC1,,,,val
US20110039830A1,COCCCOc1ccccc1I.c1ccc2[nH]ccc2c1>>COCCCOc1ccccc1-n1ccc2ccccc21,[Cu]I,CS(C)=O,,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US20100004308A1,CC(C)(C)[SiH2]OC(c1ccccc1)(c1ccccc1)c1ccc2c(CC(N)=O)coc2c1.CCOC(=O)C(=O)c1cn(C)c2ccc(F)cc12>>Cn1cc(C2=C(c3coc4cc(CO)ccc34)C(=O)NC2=O)c2cc(F)ccc21,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20150307520A1,CCC(O)c1cnc(SC)nc1Cl>>CCC(=O)c1cnc(SC)nc1Cl,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20150126449A1,Cl.Cn1nccc1-c1cccc2nn3c(C4CCN(C(=O)OC(C)(C)C)CC4)cc(=O)[nH]c3c12>>Cl.Cn1nccc1-c1cccc2nn3c(C4CCNCC4)cc(=O)[nH]c3c12,,C1COCCO1,,,,val
US05998633,CCOC(=O)C[C@@H](O)CBr.[C-]#N>>CCOC(=O)C[C@H](O)CC#N,,CCO,O,CCOC(C)=O,,val
US05403816,CN(C(=O)Cl)C1CCCCC1.COC(=O)c1c(Oc2nc(OC)cc(OC)n2)ccc[n+]1[O-]>>COC(=O)c1nc(N(C)C2CCCCC2)ccc1Oc1nc(OC)cc(OC)n1,,CC#N,O,CCN(C(C)C)C(C)C,[I-].[Na+],val
US06987119B2,C1CCNCC1.CCN(CC)CC.O=C(Cl)c1nc(-c2ccncc2)c(-c2ccc(Cl)c(Cl)c2)[nH]1>>N.O=C(c1nc(-c2ccncc2)c(-c2ccc(Cl)c(Cl)c2)[nH]1)N1CCCCC1,,ClCCl,,,,val
US20100075998A1,COC(=O)c1c[nH]c2c1CCc1cnccc1-2.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>COC(=O)c1cn(CC(F)(F)F)c2c1CCc1cnccc1-2,,CN(C)C=O,,O,,val
US20150126492A1,COc1ccc(C=O)c(F)c1OC.O=[N+]([O-])O>>COc1cc([N+](=O)[O-])c(C=O)c(F)c1OC,,O,,,,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4cc(I)ccc4nn23)CC1.Cl>>Cl.O=c1cc(C2CCNCC2)n2nc3ccc(I)cc3c2[nH]1,,C1COCCO1,CO,,,val
US20120178678A1,COc1cnn(C)c(=O)c1Cl.NN>>Cn1nccc(N)c1=O,,O,,,,val
US20030003245A1,C[Si](C)(CCCCOc1ccc(-c2ncc(OCc3ccccc3)cn2)cc1)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>C[Si](C)(CCCCOc1ccc(-c2ncc(O)cn2)cc1)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,[Pd],CCO,CCOC(C)=O,,,val
US20150344429A1,Clc1ccncc1Br.O=C1CCC1>>OC1(c2cnccc2Cl)CCC1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20130053407A1,COc1cccc(F)c1B(O)O.O=c1[nH]c(=O)c2c(ccn2-c2ccc(Br)cc2)[nH]1>>COc1cccc(F)c1-c1ccc(-n2ccc3[nH]c(=O)[nH]c(=O)c32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,ClCCl,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20100298377A1,CC(C)(C)OC(=O)N1CCCC[C@@H]1C=O.Fc1cc(Cl)cc(Br)c1>>CC(C)(C)OC(=O)N1CCCC[C@@H]1[C@@H](O)c1cc(F)cc(Cl)c1,,C1CCOC1,CCOC(C)=O,O,,val
US20050245518A1,COC(=O)c1ccc(O)cc1.O=Cc1ccc(OCCBr)cc1>>COC(=O)c1ccc(OCCOc2ccc(C=O)cc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140010762A1,CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)CC1C(=O)OC1CCCC1>>CC(C)(C)OC(=O)N1CCNCC1C(=O)OC1CCCC1,[Pd],CCOC(C)=O,,,,val
US20150051410A1,CCN.O=C1CCCC=CC[C@H]2[C@H](C[C@@H](OC3CCCCO3)[C@@H]2/C=C/[C@H](CCc2ccccc2)OC2CCCCO2)O1>>CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](OC2CCCCO2)[C@@H]1/C=C/[C@H](CCc1ccccc1)OC1CCCCO1,,C1CCOC1,O,Cl,,val
US20040024010A1,CCOC(=O)c1c(C)[nH]c(C=O)c1CCCN(C)C>>Cc1[nH]c(C=O)c(CCCN(C)C)c1C(=O)O,,CCOC(C)=O,CO,O,[Na+].[OH-],val
US20040186140A1,Cc1nc(O)c2cc(Cl)ccc2n1.O=P(Cl)(Cl)Cl>>Cc1nc(Cl)c2cc(Cl)ccc2n1,,CCOC(C)=O,,CCN(CC)CC,Cc1ccccc1,val
US20160168176A1,COC(=O)c1cc2c(o1)COC2>>O=C(O)c1cc2c(o1)COC2,,CCO,,[Na+].[OH-],,val
US20110065691A1,C[Si](C)(C)N=C=O.Cc1nn(C2CCCC2)c2cc(N3CCN[C@@H](Cc4ccccc4)C3)ccc12>>Cc1nn(C2CCCC2)c2cc(N3CCN(C(N)=O)[C@@H](Cc4ccccc4)C3)ccc12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120077760A1,N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F.O=C(O)CCCC(=O)O>>N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F.O=C([O-])CCCC(=O)[O-],,CC#N,,,,val
US20080269210A1,COCC(=O)Cl.Cc1c(-c2cccc(S(C)(=O)=O)c2)sc2c(N3CCOCC3)nc(-c3ccc(N)nc3)nc12>>COCC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3sc(-c4cccc(S(C)(=O)=O)c4)c(C)c3n2)cn1,,CN(C)C=O,c1ccncc1,,,val
US20040102634A1,CCOC(=O)C(Cc1cccc(O)c1)OC(C)C.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)C(Cc1cccc(OS(=O)(=O)C(F)(F)F)c1)OC(C)C,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20150329538A1,C1CNC1.Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1F>>Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N1CCC1,,CS(C)=O,,CO,ClCCl,val
US05912247,CO[C@H]1C[C@@H](Oc2nc(N3CCN(C(=O)OCc4ccccc4)CC3)nc3ccccc23)[C@H](O)[C@@H]1O>>CO[C@H]1C[C@@H](Oc2nc(N3CCNCC3)nc3ccccc23)[C@H](O)[C@@H]1O,[Pd],CO,,,,val
US20150018395A1,C#CCOCCOCCOS(=O)(=O)c1ccc(C)cc1.COc1ccc(N)cc1>>C#CCOCCOCCNc1ccc(OC)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060135512A1,CCOC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CC(C)CCl>>CCOC(=O)[C@@H]1CCCC[C@H]1N1CC(C)CC1=O,,CN(C)C=O,,[H-].[Na+],,val
US04266014,O=S(=O)(O)Cl.OCC(F)(F)F.c1ccccc1>>O=S(=O)(OCC(F)(F)F)c1ccccc1,,O,,[Na+].[OH-],,val
US08399444B2,CC#N.CCOC(=O)CC1CCCc2nc(C3CCCC3)n(Cc3ccc(Cl)cc3)c21>>N.O=C(O)CC1CCCc2nc(C3CCCC3)n(Cc3ccc(Cl)cc3)c21,,CC#N,CO,O,[Na+].[OH-],val
US20050171131A1,CC(=O)c1ccncc1.Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1>>CC(Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccncc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20130150339A1,CN(C)/C=C/C(=O)c1cc(C(F)(F)F)ccc1Br.NNC1CN(C(c2ccccc2)c2ccccc2)C1>>FC(F)(F)c1ccc(Br)c(-c2ccnn2C2CN(C(c3ccccc3)c3ccccc3)C2)c1,,CC(=O)O,CCO,Cl,,val
US20130059836A1,CCCN.CSc1ncc2c(Br)n[nH]c2n1>>CCCNc1ncc2c(Br)n[nH]c2n1,,C1CCOC1,,O=C(OO)c1cccc(Cl)c1,,val
US20130338196A1,CC(C)(C)[Si](C)(C)OC(c1ncco1)C1CCc2cc(OCc3ccccc3)ccc2C1.CCCC[Sn](Cl)(CCCC)CCCC>>CCCC[Sn](CCCC)(CCCC)c1cnc(C(O[Si](C)(C)C(C)(C)C)C2CCc3cc(OCc4ccccc4)ccc3C2)o1,,C1CCOC1,CCOC(C)=O,[Li]CCCC,,val
US20160108039A1,CC1CN(C(=O)OC(C)(C)C)CC(=O)N1Cc1ccccc1.CCOS(=O)(=O)C(F)(F)F>>CCC1C(=O)N(Cc2ccccc2)C(C)CN1C(=O)OC(C)(C)C,,C1CCOC1,CCOC(C)=O,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20120225061A1,COC(=O)c1ccc(F)c(-c2c(F)cc(O)cc2F)n1.O=C1CCCN1CCO>>COC(=O)c1ccc(F)c(-c2c(F)cc(OCCN3CCCC3=O)cc2F)n1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04224344,N#CCCC12CC(c3ccccc31)c1ccccc12>>NCCCC12CC(c3ccccc31)c1ccccc12,,C1COCCO1,CCOC(C)=O,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20140142084A1,COc1cc(OC)c(F)c(COc2cnc(Nc3cn[nH]c3)nc2)c1F.Cc1ccc(S(=O)(=O)OC[C@H]2COC(C)(C)O2)cc1>>COc1cc(OC)c(F)c(COc2cnc(Nc3cnn(C[C@H]4COC(C)(C)O4)c3)nc2)c1F,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20140309225A1,Brc1cncc2[nH]ncc12.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1cc(Br)c2cn[nH]c2c1,,ClC(Cl)Cl,,,,val
US20150299214A1,Cc1cc(F)ccc1Nc1c(C(=O)N2CCC(c3ccc(F)cc3)CC2)cnc(S(N)(=O)=NC(=O)OC(C)(C)C)c1Cl>>Cc1cc(F)ccc1Nc1c(C(=O)N2CCC(c3ccc(F)cc3)CC2)cnc(S(=N)(N)=O)c1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US06355653B1,Cc1ccc(O)cc1.Nc1cc(Br)cc2nc(-c3ccco3)nn12>>Cc1ccc(Oc2cc(N)n3nc(-c4ccco4)nc3c2)cc1,,CN1CCCC1=O,,,,val
US20110136763A1,CC(C)I.CCOC(=O)CC1OB(O)c2cc(O)cc(F)c21>>CCOC(=O)CC1OB(O)c2cc(OC(C)C)cc(F)c21,,CN(C)C=O,,Cl,[H-].[Na+],val
US20080081817A1,CCOc1cccc(CO)c1.CS(=O)(=O)Cl>>CCOc1cccc(COS(C)(=O)=O)c1,,ClCCl,,CCN(CC)CC,O,val
US20070155808A1,CC(C)CCNC(N)=S.O=C(CBr)c1ccc(C(F)(F)F)cc1>>CC(C)CCNc1nc(-c2ccc(C(F)(F)F)cc2)cs1,,CCO,,O,CC(=O)[O-].[Na+],val
US20070049593A1,BrCCOCc1ccccc1.N#Cc1ccc2c(C3CCCCC3)c[nH]c2n1>>N#Cc1ccc2c(C3CCCCC3)cn(CCOCc3ccccc3)c2n1,,CN(C)C=O,,O,[H-].[Na+],val
US06498254B1,Cc1ccc(C)c(C(C)S(=O)(=O)c2cccc[n+]2[O-])c1>>Cc1ccc(C)c(C(C)S(=O)(=O)c2ccccn2)c1,,ClC(Cl)Cl,,ClP(Cl)Cl,,val
US20130072470A1,C[C@@H]1C[C@H](N)C[C@@H]1c1cnc2cnc3[nH]ccc3n12.O=C(O)c1cccnn1>>C[C@H]1C[C@H](NC(=O)c2cccnn2)C[C@@H]1c1cnc2cnc3[nH]ccc3n12,,CN(C)C=O,ClCCl,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US05852011,COC(=O)Cc1ccc(N(CCCl)CCCl)cc1>>O=C(O)Cc1ccc(N(CCCl)CCCl)cc1,,O,,Cl,,val
US20050026963A1,N#Cc1cccc(F)c1.O=S(=O)(Oc1ccn(-c2ccccn2)n1)C(F)(F)F>>N#Cc1cccc(-c2ccn(-c3ccccn3)n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20150291537A1,O=S(Cl)Cl.O=[N+]([O-])c1cc(Cl)cc(CO)c1>>O=[N+]([O-])c1cc(Cl)cc(CCl)c1,,CN1CCCC1=O,ClCCl,O=C([O-])O.[Na+],,val
US06350749B1,CC(=O)C=Cc1cc(C)ccc1F.CCOC(=O)CC(=O)OCC>>Cc1ccc(F)c(C2CC(=O)CC(=O)C2)c1,,CCO,,C,C[O-].[Na+],val
US20090105258A1,C=Cc1cc(C(C)NC(=O)OC(C)(C)C)ccc1NS(=O)(=O)C=C>>C=Cc1cc(C(C)N)ccc1NS(=O)(=O)C=C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120122931A1,CCOC(=O)c1cccc(Cc2c(-c3ccsc3)[nH]c3cc(OC)ccc23)n1>>COc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccsc3)[nH]c2c1,,C1CCOC1,,CCO,[Na+].[OH-],val
US04336264,Nc1cc(-c2cccc(C(F)(F)F)c2)on1.O=C=NC(=O)c1c(Cl)cccc1Cl>>O=C(NC(=O)c1c(Cl)cccc1Cl)Nc1cc(-c2cccc(C(F)(F)F)c2)on1,,CCOC(C)=O,,,,val
US20140213588A1,CC(C)(C)[S@](=O)/N=C/CCc1ccc(Cl)c(Cl)c1.C[Mg]Br>>CC(CCc1ccc(Cl)c(Cl)c1)N[S@@](=O)C(C)(C)C,,Cc1ccccc1,ClCCl,C1CCOC1,,val
US04205170,CC(C(=O)O)c1ccc2c(c1)CCc1ccccc1S2.N>>CC(C(N)=O)c1ccc2c(c1)CCc1ccccc1S2,,ClC(Cl)Cl,O,CCN(CC)CC,CCOC(=O)Cl,val
US20080021032A1,COC(C)(C)Cn1ccc(N)n1.CS(=O)(=O)c1cccc([C@@H](CC2CCCC2)C(=O)O)c1>>COC(C)(C)Cn1ccc(NC(=O)[C@H](CC2CCCC2)c2cccc(S(C)(=O)=O)c2)n1,CN(C)C=O,ClCCl,c1ccccc1,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20090181942A1,CO.COc1cccc([C@H]2O[C@H](CCC#N)c3nnc(C4CC4)n3-c3ccc(Cl)cc32)c1OC.[OH-]>>COc1cccc([C@H]2O[C@H](CCC(=O)O)c3nnc(C4CC4)n3-c3ccc(Cl)cc32)c1OC,,CC(C)O,,Cl,,val
US05114493,CCOC(=O)CC1CCC(c2ccccc2)=CC1=O>>CCOC(=O)CC1CCC(c2ccccc2)CC1=O,[Pd],CCOC(C)=O,,,,val
US20030216442A1,O=S(=O)(Nc1ccc2c(OCc3ccc(Br)cc3)cccc2c1)C(F)(F)F.OB(O)c1cc(Cl)cc(Cl)c1>>O=S(=O)(Nc1ccc2c(OCc3ccc(-c4cc(Cl)cc(Cl)c4)cc3)cccc2c1)C(F)(F)F,,O,,CS(C)=O,,val
US08426039B2,Cc1ccccc1.OB(O)c1ccc2ccc3cccc4ccc1c2c34.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>c1ccc(C2c3ccc(-c4ccc5ccc6cccc7ccc4c5c67)cc3-c3cc(-c4ccc5ccc6cccc7ccc4c5c67)ccc3C2c2ccccc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20120058988A1,CN(CCCl)CCCl.COC(=O)c1cc(Br)nc2c1[nH]c1cc(N)ccc12>>COC(=O)c1cc(Br)nc2c1[nH]c1cc(N3CCN(C)CC3)ccc12,,CC(C)(C)O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20130035446A1,CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)c5cc([N+](=O)[O-])cc([N+](=O)[O-])c5)CC[C@]4(C)[C@H]3CC[C@]12C>>CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)c5cc(N)cc(N)c5)CC[C@]4(C)[C@H]3CC[C@]12C,[Zn],CN(C)C=O,O,,,val
US20030055085A1,BrCC1CC1.N#Cc1cc(O)cc(-c2nc(-c3ccccn3)no2)c1>>N#Cc1cc(OCC2CC2)cc(-c2nc(-c3ccccn3)no2)c1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20110046384A1,Cc1ccc(C(O)(CCN2CCCC2)c2ccccn2)cc1>>Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1,,O,,O=S(=O)(O)O,[Na+].[OH-],val
US20140200216A1,Nc1cnccc1N1CCC[C@H](NC(=O)OCc2ccccc2)C1.O=C(Nc1cc2ccc(Br)cc2nc1C(=O)O)OCc1ccccc1>>O=C(Nc1cc2ccc(Br)cc2nc1C(=O)Nc1cnccc1N1CCC[C@H](NC(=O)OCc2ccccc2)C1)OCc1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050096380A1,CC(=O)c1cc2c(c(Br)c1O)C(C)(C)CC=C2C(C)C.CCI>>CCOc1c(C(C)=O)cc2c(c1Br)C(C)(C)CC=C2C(C)C,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120289474A1,CC(C)(C)OC(=O)N1CCC(n2c(=O)[nH]c3cc(-c4ccccc4)sc3c2=O)CC1.CCn1cc(CCl)cn1>>CCn1cc(Cn2c(=O)n(C3CCN(C(=O)OC(C)(C)C)CC3)c(=O)c3sc(-c4ccccc4)cc32)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040077653A1,CCNCC.CCOC(=O)c1nnc(Cl)cc1Cl>>CCOC(=O)c1nnc(Cl)cc1N(CC)CC,,CCOC(C)=O,,,,val
US20160207926A1,CC(C)(C)OC(=O)N1CC(O)C(N=[N+]=[N-])C1>>CC(C)(C)OC(=O)N1CC(=O)C(N=[N+]=[N-])C1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20070208001A1,Cc1cc(Br)ccc1C1(O)CCC(C(=O)N[C@@H]2CC[C@H](O)CC2)CC1>>Cc1cc(Br)ccc1C1=CCC(C(=O)N[C@@H]2CC[C@H](O)CC2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110092479A1,CC(=O)Nc1n[nH]c2ncc([N+](=O)[O-])cc12.Cl>>Cl.Nc1n[nH]c2ncc([N+](=O)[O-])cc12,,CCO,,,,val
US20140051692A1,COC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc3nn2c1-c1ccc2c(c1)C(CC=CCCc1ccccc1-c1cccc-3c1)CCO2>>COC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc3nn2c1-c1ccc2c(c1)C(CCCCCc1ccccc1-c1cccc-3c1)CCO2,[Pd],CO,,,,val
US20070123512A1,Br.OCCc1ccc(O)cc1>>Oc1ccc(CCBr)cc1,,O,,,,val
US20140220573A1,Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2OCc2ccc3ccc4cccc5ccc2c3c45)c(=O)n1.O=C(OC(=O)c1ccccc1)c1ccccc1>>O=C(Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2OCc2ccc3ccc4cccc5ccc2c3c45)c(=O)n1)c1ccccc1,,CN(C)C=O,ClCCl,,,val
US20100183603A1,N#C/C=C/c1cn2c3c(cccc13)CCC2>>N#CCCc1cn2c3c(cccc13)CCC2,[Pd],CO,,[H][H],,val
US20130338196A1,CC(C)(C)[Si](C)(C)OC(c1ncco1)C1CCc2cc(-c3ccccc3)ccc2C1.COC(=O)C#N>>COC(=O)c1cnc(C(O[Si](C)(C)C(C)(C)C)C2CCc3cc(-c4ccccc4)ccc3C2)o1,,C1CCOC1,CCOC(C)=O,[Li]CCCC,,val
US20070117954A1,O=C(O)C1=C(C(=O)O)C2c3ccccc3C1c1ccccc12>>O=C1OC(=O)C2=C1C1c3ccccc3C2c2ccccc21,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20060142366A1,CC(C)(C)OC(=O)c1ccc2[nH]ccc2c1.O=C1CCC(=O)N1Cl>>CC(C)(C)OC(=O)c1ccc2[nH]cc(Cl)c2c1,,CO,,,,val
US20110071197A1,COC(=O)c1cc(F)ccc1[N+](=O)[O-].COC(=O)c1cc(O)ccc1NC(C)=O>>COC(=O)c1cc(Oc2ccc([N+](=O)[O-])c(C(=O)OC)c2)ccc1NC(C)=O,,CN(C)C=O,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.Cc1ccc(O)c(C(=O)c2ccccc2)c1>>COc1cc2nccc(Oc3ccc(C)cc3C(=O)c3ccccc3)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,,,val
US04902719,C=CC(O)CCC(CF)N1C(=O)c2ccccc2C1=O.O=C1NC(=O)c2ccccc21>>C=CC(CCC(CF)N1C(=O)c2ccccc2C1=O)N1C(=O)c2ccccc2C1=O,,C1CCOC1,O,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050288273A1,CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCCC3=O)C(=O)O1.Cc1nnsc1C(=O)Cl>>CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCC(C(=O)c2snnc2C)C3=O)C(=O)O1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100105700A1,CN1C(=O)CC[C@@]2(C)C1=CC[C@H]1[C@@H]3CC=C(OS(=O)(=O)C(F)(F)F)[C@@]3(C)CC[C@@H]12.COc1ccc(B(O)O)cn1>>COc1ccc(C2=CC[C@H]3[C@@H]4CC=C5N(C)C(=O)CC[C@]5(C)[C@H]4CC[C@]23C)cn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,,,val
US20050148648A1,COc1ccc(C2(CN)CCCC2)cc1OC.Cc1oc(-c2ccccc2)cc1C(=O)O>>COc1ccc(C2(CNC(=O)c3cc(-c4ccccc4)oc3C)CCCC2)cc1OC,,CC#N,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090270374A1,CCOC(=O)COc1c(N)nc(/C=C/c2ccccc2)nc1Cl>>O=C1COc2c(Cl)nc(/C=C/c3ccccc3)nc2N1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140045828A1,O=C(CCl)N[C@@]1(CO)c2cc(Br)ccc2Oc2ccc(I)cc21>>O=C1COC[C@]2(N1)c1cc(Br)ccc1Oc1ccc(I)cc12,,CCC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20050148623A1,COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCN(Cc2ccccc2[N+](=O)[O-])C1=O)C(C)(C)C)C(C)(C)C>>COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCN(Cc2ccccc2N)C1=O)C(C)(C)C)C(C)(C)C,[Pd],CCO,,,,val
US20140378475A1,Cc1c(N)cccc1Br.O=c1[nH]c2c(F)cccc2c(=O)o1>>Cc1c(Br)cccc1NC(=O)c1cccc(F)c1N,,,,,,val
US20140228361A1,CC(C)(C)OC(=O)N1CCC2CNCCC21.ClCCCBr>>CC(C)(C)OC(=O)N1CCC2CN(CCCCl)CCC21,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20150045326A1,COC(=O)c1nc(Cl)c(N)nc1N>>Nc1nc(N)c(C(=O)O)nc1Cl,,C1COCCO1,,Cl,[Na+].[OH-],val
US20050107449A1,CCOC(=O)C(C)c1nc(-c2ccc(C(F)(F)F)cc2)sc1CC>>CCc1sc(-c2ccc(C(F)(F)F)cc2)nc1C(C)CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US07015218B1,CC(C)(C)OC(=O)N1CCCN(c2ccc([N+](=O)[O-])cc2C#N)CC1>>CC(C)(C)OC(=O)N1CCCN(c2ccc(N)cc2C#N)CC1,[Fe],CCO,,O,[Cl-].[NH4+],val
US06613942B1,CC(C)c1ccc(CCl)cc1.COc1cc(C=O)cc(OC)c1O>>COc1cc(C=O)cc(OC)c1OCc1ccc(C(C)C)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160229856A1,CC(C)(C)OC(=O)NCCCCCCOS(C)(=O)=O.COC(=O)c1cccc(-c2cn[nH]c2)n1>>COC(=O)c1cccc(-c2cnn(CCCCCCN)c2)n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100130506A1,CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)CN1C(=O)c2ccccc2C1=O>>CC(C)(C)OC(=O)N[C@H](CN)CCCCNC(=O)OCc1ccccc1,,CCO,ClCCl,NN,O,val
US20060094767A1,FC(F)(F)c1ccc(OC2CCN(CCOC3CCCCO3)CC2)cc1>>OCCN1CCC(Oc2ccc(C(F)(F)F)cc2)CC1,,CCO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US05459137,CC(=O)OC(C)=O.CC1=NN=C(c2ccc(N)cc2)c2cc3c(cc2C1)OCO3>>CC(=O)Nc1ccc(C2=NN=C(C)Cc3cc4c(cc32)OCO4)cc1,,CCO,,,,val
US20060074095A1,CCCN.Clc1nc(Cl)c2[nH]cnc2n1>>CCCNc1[nH]c(Cl)nc2ncnc1-2,,CCCCO,,,,val
US20120302541A1,COc1ccc(Oc2ccc([N+](=O)[O-])c(Oc3ccc(OC)cc3)c2)cc1>>COc1ccc(Oc2ccc(N)c(Oc3ccc(OC)cc3)c2)cc1,[Pd],CCO,CCOC(C)=O,,,val
US20150166505A1,CCO.FC(F)(F)c1cc(Cl)ncc1Br>>CCOc1cc(C(F)(F)F)c(Br)cn1,,CCO,,C,C[O-].[Na+],val
US20100093721A1,Cc1ccc(-c2nc(N)c3cc(C(O)CO)sc3n2)o1>>Cc1ccc(-c2nc(N)c3cc(C=O)sc3n2)o1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US05693636,COc1ccc(CS)cc1.O=C(O)c1cc([N+](=O)[O-])ccc1Cl>>COc1ccc(CSc2ccc([N+](=O)[O-])cc2C(=O)O)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05130119,COC(=O)CS(=O)(=O)Nc1ccc(F)cc1F>>O=C(O)CS(=O)(=O)Nc1ccc(F)cc1F,,C1COCCO1,,[Na+].[OH-],,val
US20090270663A1,Br[Mg]CCc1ccccc1.CC(Cl)C(=O)Cl>>CC(Cl)C(=O)CCc1ccccc1,,C1CCOC1,,,,val
US20110034440A1,Cc1ccc(C(=O)OC(C)(C)C)cc1N(CC(=O)NCCNC(C)C)CC(=O)N(C)N1Cc2ccccc2C1>>Cc1ccc(C(=O)O)cc1N(CC(=O)NCCNC(C)C)CC(=O)N(C)N1Cc2ccccc2C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090264434A1,CCOC(=O)C(CC(CC)CC)C(=O)OCC>>CCC(CC)CC(C(=O)O)C(=O)O,,CCO,O,[K+].[OH-],,val
US20100305070A1,BrP(Br)Br.CCOC(COc1c(F)cc(F)cc1C=O)OCC>>Fc1cc(F)c2oc(CBr)cc2c1,,CC(=O)O,,[BH4-].[Na+],,val
US06977105B1,C1CCCCC1.C=CC(=C)C.C=Cc1ccccc1.CN(C)CCN(C)C.[Li]C(C)CC>>C=CC(=C)C.C=Cc1ccccc1.C=Cc1ccccc1.C=Cc1ccccc1,,C1CCCCC1,,,,val
US20140343000A1,C=C(C)[C@@H]1CC[C@]2(NCCO[Si](C)(C)C(C)(C)C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(NCCO)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040121964A1,CCOC(=O)[C@H](CCC(=O)CC)NC(=O)OC(C)(C)C>>CCOC(=O)[C@@H]1CCC(CC)=N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05280043,Nc1ccc(CCCC(=O)O)cc1.O=S(=O)(Cl)c1ccccc1>>O=C(O)CCCc1ccc(NS(=O)(=O)c2ccccc2)cc1,,CC(C)=O,,c1ccncc1,,val
US20120015962A1,CC(C)(C)[Si](C)(C)Cl.COc1cc2nc(NCCO)ccc2cc1N>>COc1cc2nc(NCCO[Si](C)(C)C(C)(C)C)ccc2cc1N,,ClCCl,,c1c[nH]cn1,,val
US20120283209A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CCN(CC)CC.ClCCl.NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O.O=S(=O)(O)O>>C=C(O[Si](C)(C)C(C)(C)C)C(=O)OCC,,ClCCl,,,,val
US20040142954A1,CCN(CC)c1ncc(NCS(=O)(=O)c2ccc(F)cc2)c(NC(Cc2ccc(OC(=O)N(C)C)cc2)C(=O)OC(C)(C)C)n1.Cl>>CCN(CC)c1ncc(NCS(=O)(=O)c2ccc(F)cc2)c(NC(Cc2ccc(OC(=O)N(C)C)cc2)C(=O)O)n1.Cl,,O=CO,,,,val
US20070249607A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)(c2ccccc2F)CC1>>CC(C)(C)OC(=O)N1CCC(CO)(c2ccccc2F)CC1,,C1CCOC1,,B,,val
US20040138269A1,CCOC(=O)c1[nH]c(C)c(-c2ccc(C(=O)O)cc2)c1C.Nc1ccccc1>>CCOC(=O)c1[nH]c(C)c(-c2ccc(C(=O)Nc3ccccc3)cc2)c1C,CN(C)C=O,CCOC(C)=O,ClCCl,O=C(Cl)C(=O)Cl,O=C([O-])O.[Na+],val
US20030078249A1,COc1cc(CC(=O)OC(C)(C)C)ccc1N.COc1ccccc1N=C=O>>COc1ccccc1NC(=O)Nc1ccc(CC(=O)OC(C)(C)C)cc1OC,,C1CCOC1,,CCN(CC)CC,,val
US04898872,Cc1cc(=O)[nH]c2c(C)cc(N)cc12>>Cc1cc(N)cc2c1NC(=O)CC2C,,CCO,,C,,val
US20160031875A1,C#CC(=O)OC(C)(C)C.OCC1CCCCC1>>CC(C)(C)OC(=O)C=COCC1CCCCC1,,C1CCOC1,,C1CN2CCN1CC2,,val
US20020165234A1,CC(C)CN(C[C@H](O)COc1cccc2[nH]c3ccccc3c12)c1ccc(O)cc1.N#CCCCBr>>CC(C)CN(C[C@H](O)COc1cccc2[nH]c3ccccc3c12)c1ccc(OCCCC#N)cc1,,CCC(C)=O,,[I-].[K+],,val
US20120172358A1,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOCC.O=C(O)N1CCC(O)(CCCO)CC1>>CC(C)(C)OC(=O)N1CCC2(CCC(O)O2)CC1,,CCOCC,ClCCl,,,val
US20150018309A1,CC(C)(C)OC(=O)N1CC(Sc2ccccc2)C1>>c1ccc(SC2CNC2)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US06127402,COC(=O)Cc1cccn1C.O=[N+]([O-])c1ccc(Cl)cc1>>COC(=O)C(c1ccc([N+](=O)[O-])cc1)c1cccn1C,,CN(C)C=O,,[H-].[Na+],,val
US20130053362A1,BrCC1CC1.Oc1ccc(Br)cn1>>O=c1ccc(Br)cn1CC1CC1,,CCOC(C)=O,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US04746671,COC(OC)c1ccccc1Br.O=Cc1cccnc1>>COC(OC)c1ccccc1C(O)c1cccnc1,,CCCCCC,,CCOCC,[Li]CCCC,val
US20110301355A1,CCOC(=O)C(C)Br.NC(=O)C(=Nc1cc(O)c(Cl)cc1Cl)N1CCCC1>>CCOC(=O)C(C)Oc1cc(N=C(C(N)=O)N2CCCC2)c(Cl)cc1Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150246934A1,CCOC(=O)CCl.N#Cc1cc(O)cc(O)c1>>CCOC(=O)COc1cc(O)cc(C#N)c1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20160251340A1,C[C@@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(Oc2cccc3c2C(C)(C)CO3)nc1>>C[C@@H](N)C(=O)Nc1ccc(Oc2cccc3c2C(C)(C)CO3)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070161685A1,COC(=O)C[C@](NC(=O)C(C)(C)C)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1>>CC(C)(C)C(=O)N[C@@](CC(=O)O)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1,,C1CCOC1,CCOC(C)=O,Cl,[Li+].[OH-],val
US20040132708A1,BrCCCBr.COC(=O)c1ccc2[nH]c(=S)[nH]c2c1>>OCc1ccc2c(c1)nc1n2CCS1,,CCO,CN(C)C=O,Cl,[Na+].[OH-],val
US20080287458A1,CC(C)(N)CC(=O)O.O=C(Cl)OCc1ccccc1>>CC(C)(CC(=O)O)NC(=O)OCc1ccccc1,,[Na+],[OH-],CCOCC,,val
US20040138251A1,COC(=O)CCCc1cc2c(Cl)c(C#N)cnc2s1.COc1cc(N)cc(OC)c1OC>>COC(=O)CCCc1cc2c(Nc3cc(OC)c(OC)c(OC)c3)c(C#N)cnc2s1,,CCOCCO,,Cl,c1ccncc1,val
US20050043374A1,CC(=O)CCl.NC(=S)c1ccc(N2C[C@H](Cn3ccnn3)OC2=O)cc1F>>Cc1csc(-c2ccc(N3C[C@H](Cn4ccnn4)OC3=O)cc2F)n1,,CN(C)C=O,,,,val
US20100144710A1,CCCCNc1ccc(CC(=O)N2CCN(c3ncccc3C#N)CC2)cc1.CI>>CCCCN(C)c1ccc(CC(=O)N2CCN(c3ncccc3C#N)CC2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20160264518A1,COC(=O)/C=C/c1ccccc1N.O=Cc1nc(Cl)c(Cl)[nH]1>>COC(=O)/C=C/c1ccccc1NCc1nc(Cl)c(Cl)[nH]1,,CC(=O)O,,,,val
US06689806B1,O=C1Cc2ccc(Br)cc2N1.OB(O)c1ccsc1>>O=C1Cc2ccc(-c3ccsc3)cc2N1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,Cc1ccccc1,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20120178715A1,CC(C)(C)[S@](=O)N[C@@H](CO[Si](C)(C)C(C)(C)C)c1ccc(F)cc1F.Cl>>Cl.N[C@@H](CO)c1ccc(F)cc1F,,CO,,C1COCCO1,,val
US20120040879A1,C=COCC.Cl[SiH2]C(C1CC1)C1CC1>>C=C(C[SiH](C1CC1)C1CC1)OCC,,C1CCOC1,O,CCCCC,[Li]C(C)(C)C,val
US20040110945A1,COC(=O)c1nn(C(C)=O)c2ccccc12>>O=C(O)c1n[nH]c2ccccc12,,Cl,,O,[Na+].[OH-],val
US20160264518A1,COC(=O)/C=C/c1ccccc1N1CC2(CC(NC(=O)OCc3ccccc3)CS2(=O)=O)C1.NO>>O=C(/C=C/c1ccccc1N1CC2(CC(NC(=O)OCc3ccccc3)CS2(=O)=O)C1)NO,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20130296555A1,CC(C)(C)OC(=O)NCC(=O)NNC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OCc1ccccc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)(C)OC(=O)NCc1nnc([C@@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)s1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20150073146A1,CCCSc1nc(Cl)c(N)c(N[C@@H]2C[C@H](OCCO)[C@H]3OC(C)(C)O[C@@H]23)n1.O=N[O-]>>CCCSc1nc(Cl)c2nnn([C@@H]3C[C@H](OCCO)[C@@H](O)[C@H]3O)c2n1,,O,,Cl,,val
US05547975,C=CC(=O)O.COc1cccc(S)c1>>COc1cccc(SCCC(=O)O)c1,,CCOCC,,,,val
US04910190,N.O=S(=O)(Cl)c1cccc2ccccc12>>NS(=O)(=O)c1cccc2ccccc12,,CCOCC,,,,val
US20050288337A1,COC(=O)CCc1ccc(Cn2cccc(-c3ccc(N)cc3)c2=O)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.c1ccc2c(c1)CCN2>>COC(=O)CCc1ccc(Cn2cccc(-c3ccc(NC(=O)N4CCc5ccccc54)cc3)c2=O)cc1,,C1CCOC1,,CCOC(C)=O,,val
US04035376,CC(Br)c1ccc(C(=O)c2ccc(Cl)s2)cc1.[C-]#N>>CC(C#N)c1ccc(C(=O)c2ccc(Cl)s2)cc1,,C1COCCO1,,O,,val
US20130156732A1,C[C@H]1CC[C@@H](C(=O)O)N1C(=O)OC(C)(C)C.O=C1c2cc3c(cc2CCC1Br)-c1ccc(Cl)cc1CO3>>C[C@H]1CC[C@@H](C(=O)OC2CCc3cc4c(cc3C2=O)OCc2cc(Cl)ccc2-4)N1C(=O)OC(C)(C)C,,CC#N,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20090048258A1,CCOc1cc(C)c(C(=O)CCC(=O)O)cc1OCC.Nc1nc(-c2ccccc2)c(Cc2ccccc2)s1>>CCOc1cc(C)c(C(=O)CCC(=O)Nc2nc(-c3ccccc3)c(Cc3ccccc3)s2)cc1OCC,,CC#N,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20100099728A1,O=C1Nc2cccc(Cl)c2C1(O)c1cc2c(cc1O)OCO2>>O=C1Nc2cccc(Cl)c2C1c1cc2c(cc1O)OCO2,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20070135385A1,CCCCCCCCI.COc1nccc2[nH]c(C)cc12>>CCCCCCCCn1c(C)cc2c(OC)nccc21,,C1CCOC1,,[H-].[Na+],,val
US20040106615A1,CC(C)N.COC(=O)c1ccc(-c2cc(F)ncc2Cl)cc1>>COC(=O)c1ccc(-c2cc(NC(C)C)ncc2Cl)cc1,,CS(C)=O,O,,,val
US04705790,Nc1cc(Cl)nc(Cl)n1.O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(C(F)(F)F)c1>>NC1=NC(Cl)N(c2c([N+](=O)[O-])cc([N+](=O)[O-])cc2C(F)(F)F)C(Cl)=C1,,C1CCOC1,,Cl,[K+].[OH-],val
US20060094708A1,COP(=O)(OC)OCC[C@H](Cc1ccc(-c2cn(C)c(C(C)=O)n2)cc1)NC(=O)c1ccc(OC(C)C)c(Cl)c1>>CC(=O)c1nc(-c2ccc(C[C@@H](CCOP(=O)(O)O)NC(=O)c3ccc(OC(C)C)c(Cl)c3)cc2)cn1C,,Br,CC(=O)O,,,val
US20080153837A1,NC(=O)[C@@H](CC(=O)NC1c2ccccc2-c2c(-c3nc4ccncc4[nH]3)cccc21)NC(=O)O>>NC(=O)[C@H](N)CC(=O)NC1c2ccccc2-c2c(-c3nc4ccncc4[nH]3)cccc21,,C1COCCO1,,Cl,,val
US04102888,C#C[C@H](CCCCC)OC(C)=O.C=O.CCNCC>>CCCCC[C@@H](C#CCN(CC)CC)OC(C)=O,,CCOCC,,C1COCCO1,,val
US20070066618A1,CS(=O)(=O)c1ccc(Cl)c([N+](=O)[O-])c1.Nc1ccc(CCO)cc1>>CS(=O)(=O)c1ccc(Nc2ccc(CCO)cc2)c([N+](=O)[O-])c1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20150266824A1,CC(C)=C1C[C@H](CO)NC1=O>>CC(C)C1C[C@H](CO)NC1=O,O=[Pt]=O,CCOC(C)=O,,CO,,val
US20090118501A1,CCOC(=O)Cc1nc(NC(=O)N(C2CCCCC2)C2CCCCC2)sc1Cl.CN1CCNCC1>>CCOC(=O)Cc1nc(NC(=O)N(C2CCCCC2)C2CCCCC2)sc1N1CCN(C)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20050256140A1,Cn1cnc(-c2ccccc2)c1-c1cc2c(S(C)(=O)=O)ncnc2s1.N>>Cn1cnc(-c2ccccc2)c1-c1cc2c(N)ncnc2s1,,C1COCCO1,,,,val
US06197976B1,C1CCNCC1.O=C(Cl)c1ccccc1>>O=C(c1ccccc1)N1CCCCC1,,O,,Cc1ccccc1,[Na+].[OH-],val
US20150353535A1,CCOC(=O)[C@H]1CCC(=O)C[C@H]1C.Cc1cc(Br)nc(-c2cncs2)c1>>CCOC(=O)[C@H]1CCC(O)(c2ncc(-c3cc(C)cc(Br)n3)s2)C[C@H]1C,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20090036485A1,COc1cc2nccc(Oc3cnn(CC(=O)O)c3)c2cc1C#N.Nc1cccc(F)c1>>COc1cc2nccc(Oc3cnn(CC(=O)Nc4cccc(F)c4)c3)c2cc1C#N,,O,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20090312383A1,CCC(CC)c1ccc(OC)c2nc(Oc3ccc(Cl)cc3Br)n(C)c12>>CCC(CC)c1ccc(O)c2nc(Oc3ccc(Cl)cc3Br)n(C)c12,,ClCCl,,BrB(Br)Br,,val
US20070066624A1,COC(=O)CBr.Cc1nc(Oc2ccc(N)cc2)ccc1CN1CCC(N2C(=O)OC[C@H]2c2ccccc2)CC1>>COC(=O)CNc1ccc(Oc2ccc(CN3CCC(N4C(=O)OC[C@H]4c4ccccc4)CC3)c(C)n2)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US05635518,CCOC(=O)[C@@H]1CCCN(CCOc2ccccc2Cc2ccccc2)C1.Cl>>Cl.O=C(O)[C@@H]1CCCN(CCOc2ccccc2Cc2ccccc2)C1,,CC(C)=O,CCO,ClCCl,[Na+].[OH-],val
US20070185142A1,CC(=O)OC(C)=O.O=C1Nc2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2CN1N=Cc1cccnc1>>CC(=O)N1C(=O)N(N=Cc2cccnc2)Cc2cc(C(F)(C(F)(F)F)C(F)(F)F)ccc21,,CC(=O)N(C)C,,[H-].[Na+],,val
US20020010371A1,CC(C)(C)OC(=O)CC1(C#N)CCCCC1>>N#CC1(CC(=O)O)CCCCC1,,O=C(O)C(F)(F)F,,COc1ccccc1,,val
US04187216,C[C@H](N)C(=O)N1CCC[C@H]1C(=O)Nc1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>C[C@H](NC(=O)C(F)(F)F)C(=O)N1CCC[C@H]1C(=O)Nc1ccccc1,,c1ccncc1,,Br,,val
US04283420,COC(=O)C1(C(C)=O)CCCCC1.ClP(Cl)(Cl)(Cl)Cl>>C=C(Cl)C1(C(=O)OC)CCCCC1,,ClCCl,,,,val
US20050288273A1,CC(C)(C)OC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCc2cnoc2-3)C(=O)O1.Cl>>Cl.NC[C@H]1CN(c2ccc3c(c2)CCCc2cnoc2-3)C(=O)O1,,C1COCCO1,,,,val
US20100056530A1,COC=Cc1cnc(Nc2nc(C)cs2)c(OCc2ccccc2)c1>>Cc1csc(Nc2ncc(CC=O)cc2OCc2ccccc2)n1,,C1CCOC1,,Cl,,val
US20060089380A1,Cc1ccc2c(Cl)cc(Cl)c(O)c2n1.O=[Se]=O>>O=Cc1ccc2c(Cl)cc(Cl)c(O)c2n1,,C1COCCO1,,,,val
US20130079313A1,CC(C)(C)OC(=O)Oc1ccc(N(CC2CC2)S(C)(=O)=O)cc1C(=O)O.O=C(CO)OCc1ccccc1>>CC(C)(C)OC(=O)Oc1ccc(N(CC2CC2)S(C)(=O)=O)cc1C(=O)OCC(=O)OCc1ccccc1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20020147192A1,O=C(NCc1ccc(CO)cc1)c1c(Cl)cncc1Cl>>O=Cc1ccc(CNC(=O)c2c(Cl)cncc2Cl)cc1,O=[Mn]=O,CO,ClCCl,,,val
US04665182,COCC1=Nc2c(nc(N)[nH]c2=O)NC1(C)C.Cl>>COCC1Nc2c(nc(N)[nH]c2=O)NC1(C)C.Cl,O=[Pt],,,,,val
US20120053173A1,CCOC(=O)CCNC(=O)c1ccc(NC(c2sc3ccccc3c2C)C2CCCCC2)cn1>>Cc1c(C(Nc2ccc(C(=O)NCCC(=O)O)nc2)C2CCCCC2)sc2ccccc12,,CCO,,C1CCOC1,[Na+].[OH-],val
US20100190782A1,COC(=O)c1nc(-c2ccc3c(c2)N(C(=O)Nc2nc4ccccc4s2)CCN3C)ccc1OCCCOc1ccccc1>>CN1CCN(C(=O)Nc2nc3ccccc3s2)c2cc(-c3ccc(OCCCOc4ccccc4)c(C(=O)O)n3)ccc21,,CO,O,Cl,[Li+].[OH-],val
US04115416,CCCCCCCC(Oc1ccc(C2=CCCCC2)cc1)C(=O)OCC>>CCCCCCCC(Oc1ccc(C2=CCCCC2)cc1)C(=O)O,,CCO,,[Na+].[OH-],,val
US20060148858A1,Cn1cc(C=O)c(OCc2ccccc2)n1.[C-]#[N+]CS(=O)(=O)c1ccccc1C>>Cn1nc(OCc2ccccc2)cc1CC#N,,CO,COCCOC,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US08022062B2,CC(=O)OC(F)(F)F.CCOC(C)=O.CN(C)C(=O)Sc1c(Br)ccc2c1CCN(C(=O)C(F)(F)F)CC2.CN1CCCC1=O>>CN(C)C(=O)Sc1c(C(F)(F)F)ccc2c1CCN(C(=O)OC(C)(C)C)CC2,[Cu]I,CCOC(C)=O,CN1CCCC1=O,O,[Na],val
US20150111869A1,CC[Si](C)(C)Cl.C[Si](C)(C)CC(=O)[O-]>>CC[Si](C)(C)CC(=O)O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US04918073,CCOC(=O)NC1CCN(Cc2ccccc2)CC1>>CCOC(=O)NC1CCNCC1,[Pd],CO,,Cl,,val
US20150119362A1,COC(=O)CC(Br)C=O.NC(N)=O>>COC(=O)Cc1cnc(N)o1,,CN(C)C=O,,,,val
US20020143034A1,Cl.N#Cc1cccnc1Oc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1>>Cl.N#Cc1cccnc1Oc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1,,CCOC(C)=O,,,,val
US20060014948A1,COc1cc(C[C@@H](NC(=O)OC(C)(C)C)C(=O)OCc2ccccc2)ccc1O.Cl>>COc1cc(C[C@@H](N)C(=O)OCc2ccccc2)ccc1O.Cl,,C1COCCO1,ClCCl,,,val
US20030166644A1,CC(C)N(C)C1CCNCC1.O=C(Cl)Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1>>CC(C)N(C)C1CCN(C(=O)Oc2ccc(Oc3ccc(C(F)(F)F)cn3)cc2)CC1,,CN(C)C=O,,Cl,Cl,val
US20050222147A1,Cc1oc(-c2ccc(F)cc2)nc1CC(=O)NC[C@H]1CNCCO1.O=CCCc1ccc(Cl)cc1>>Cc1oc(-c2ccc(F)cc2)nc1CC(=O)NC[C@H]1CN(CCCc2ccc(Cl)cc2)CCO1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20050137243A1,O=[N+]([O-])c1cccc2c1cnn2CCN1CCCCC1>>Nc1cccc2c1cnn2CCN1CCCCC1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20100068204A1,O=c1[nH]c2cc(Cl)ccc2c(Oc2cccc([N+](=O)[O-])c2)c1I>>Nc1cccc(Oc2cc(=O)[nH]c3cc(Cl)ccc23)c1,[Zn],CC(=O)O,,CCO,,val
US20040086548A1,C=C(C)C(=O)OCCO.O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N=C=S)cc21>>C=C(C)C(=O)O.O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N=C=S)cc21,,O,,,,val
US06436966B1,CCOC(=O)c1cccnc1.N#CCc1ccccc1>>N#CC(C(=O)c1cccnc1)c1ccccc1,,CC(C)(C)O,O,CC(C)(C)[O-].[K+],,val
US20160194302A1,CCOC(=O)CCn1ccnc1CCC(=O)O.CN(C)[C@H]1CCNC1>>CCOC(=O)CCn1ccnc1CCC(=O)N1CC[C@H](N(C)C)C1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100016164A1,CC(C)COC(=O)Cl.CC1CCN(Cc2ccccc2NS(=O)(=O)C(F)(F)F)C(=O)OC1>>CC(C)COC(=O)N(c1ccccc1CN1CCC(C)COC1=O)S(=O)(=O)C(F)(F)F,,CC#N,,O,O=C([O-])O.[Na+],val
US20140057303A1,Cc1cc(C#N)c(N)s1.N#Cc1ccc(F)c([N+](=O)[O-])c1>>Cc1cc(C#N)c(Nc2ccc(C#N)cc2[N+](=O)[O-])s1,,C1CCOC1,,Cl,[H-].[Na+],val
US06197975B1,CS(=O)(=O)Cl.Cc1cc(C)cc(-c2[nH]c3ccc([N+](=O)[O-])cc3c2CCN(CCCCc2ccc(NS(C)(=O)=O)cc2)C(=O)OC(C)(C)C)c1>>Cc1cc(C)cc(-c2[nH]c3ccc([N+](=O)[O-])cc3c2CCN(CCCCc2ccc(N)c(S(C)(=O)=O)c2S(C)(=O)=O)C(=O)OC(C)(C)C)c1,,CCN(CC)CC,,,,val
US20080214581A1,COS(=O)(=O)c1ccc(C)cc1.O=C1NCCc2cncn21>>C[n+]1cc2n(c1)C(=O)NCC2.Cc1ccc(S(=O)(=O)[O-])cc1,,CN(C)C=O,,,,val
US20070249670A1,CCOC(=O)c1nc(-c2ccc(OC)cc2)oc1OCC>>CCOc1oc(-c2ccc(OC)cc2)nc1C(=O)O,,C1CCOC1,,Cl,[Li+].[OH-],val
US20100022540A1,Cc1ccccc1N.O=C(Cl)c1cc(Br)c(OCc2ccccc2)cc1OCc1ccccc1>>Cc1ccccc1NC(=O)c1cc(Br)c(OCc2ccccc2)cc1OCc1ccccc1,,ClCCl,,c1ccncc1,,val
US20110092479A1,CCOC(=O)C(F)(F)F.Fc1ccccn1>>O=C(c1cccnc1F)C(F)(F)F,,C1CCOC1,,Cl,CC(C)[N-]C(C)C.[Li+],val
US20080108638A1,BrCc1ccccc1.CC(C)(C)OC(=O)Cn1c(S)nc2ccccc21.CC(C)=O>>CC(Sc1nc2ccccc2n1CC(=O)OC(C)(C)C)c1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110195977A1,COc1ccc(/C=C/C(=O)O)cc1OC(C)=O.Nc1ccc(Cl)c(OCc2ccncc2)c1>>COc1ccc(/C=C/C(=O)Nc2ccc(Cl)c(OCc3ccncc3)c2)cc1OC(C)=O,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US20090099156A1,CC(C)(C)OC(=O)N1CCO[C@@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1>>O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@H]2CNCCO2)CC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100256200A1,CC(C)(C)CC(C)(C)N.O=S(=O)(Cl)c1ccc(Cl)nc1>>CC(C)(C)CC(C)(C)NS(=O)(=O)c1ccc(Cl)nc1,,ClCCl,,CCN(CC)CC,,val
US20110130412A1,C=O.NCCO.O=c1[nH]cnc2cc[nH]c12>>O=c1[nH]cnc2c(CNCCO)c[nH]c12,,O,,,,val
US20150087639A1,CC(C)CN(CC(C)C)c1ccc([N+](=O)[O-])cc1F>>CC(C)CN(CC(C)C)c1ccc(N)cc1F,[Pd],CO,,ClCCl,,val
US06162824,COC(=O)[C@H](CO)NC(=O)OCC1c2ccccc2-c2ccccc21.OC1(c2ccccc2)c2ccccc2-c2ccccc21>>COC(=O)[C@H](COC1(c2ccccc2)c2ccccc2-c2ccccc21)NC(=O)OCC1c2ccccc2-c2ccccc21,O=S(=O)(O)O,c1ccccc1,,,,val
US20030212111A1,CCNc1ccc(C#N)cc1N=C1SC(=C2Sc3ccc(O)cc3N2C)C(=O)N1Cc1ccccc1.COC(=O)CBr>>CCNc1ccc(C#N)cc1N=C1SC(=C2Sc3ccc(OCC(=O)OC)cc3N2C)C(=O)N1Cc1ccccc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090131467A1,NN.O=C(Cc1ccccc1)c1c(O)c2cccnc2n(-c2cccc(OC(F)(F)F)c2)c1=O>>O=c1c2c(Cc3ccccc3)n[nH]c2c2cccnc2n1-c1cccc(OC(F)(F)F)c1,,CN(C)C=O,,O,O,val
US20060217372A1,N#Cc1ccc(Oc2ccc(C=O)cc2F)nc1.c1ccc(C2CCNC2)cc1>>N#Cc1ccc(Oc2ccc(CN3CCC(c4ccccc4)C3)cc2F)nc1,,CCOC(C)=O,ClCCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US06528663B1,C=CC(=C)Cl.O=C1C=CC(=O)O1>>O=C1OC(=O)C2CC(Cl)C=CC12,,Cc1ccccc1C,,Cc1ccccc1,,val
US20090099356A1,C1CCNC1.CCCC[Sn](/C=C/CCOS(=O)(=O)c1ccc(C)cc1)(CCCC)CCCC>>CCCC[Sn](/C=C/CCN1CCCC1)(CCCC)CCCC,,C1CCOC1,,,,val
US20040132752A1,COC(CNc1ccc(Oc2ccccc2)cc1)OC.Nc1ccc(OCc2ccccc2)cc1.O=C(n1ccnc1)n1ccnc1>>COC(CN(C(=O)Nc1ccc(OCc2ccccc2)cc1)c1ccc(Oc2ccccc2)cc1)OC,,CN(C)C=O,,,,val
US20150166564A1,Cc1c(N=O)c(-c2ccccc2)nn1CC(F)(F)F>>Cc1c(N)c(-c2ccccc2)nn1CC(F)(F)F,[Zn],CCO,CO,Cl,,val
US05075313,COC(=O)c1ccccc1N.O=C(O)Cc1c[nH]c2ccccc12>>COC(=O)c1ccccc1NC(=O)Cc1c[nH]c2ccccc12,,C1CCOC1,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US07238716B2,CCOC(=O)CCc1c(OCc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)ccc2ccccc12>>Cc1oc(-c2ccccc2)nc1COc1ccc(COc2ccc3ccccc3c2CCC(=O)O)cc1,,CCO,,C1CCOC1,[Na+].[OH-],val
US20150376160A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4sc(F)cc4NC(=O)O[C@H](C)c4ccccc4)cc3)cc2)CC1>>C[C@@H](OC(=O)Nc1cc(F)sc1-c1ccc(-c2ccc(C3(C(=O)O)CC3)cc2)cc1)c1ccccc1,,CC(C)O,,Cl,[Na+].[OH-],val
US04962115,COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC>>COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC,,Cc1ccccc1,,O,O,val
US20130109686A1,CC(C)(C)[Si](C)(C)O[C@H]1CCCC[C@@H]1N1C(=O)c2cc(Cc3ccc(Cl)nc3)c3cccnc3c2C1CC=O.CNC>>CN(C)CCC1c2c(cc(Cc3ccc(Cl)nc3)c3cccnc23)C(=O)N1[C@H]1CCCC[C@@H]1O,,ClCCCl,,CC(=O)O,[BH3-]C#N.[Na+],val
US20130116246A1,C[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cncc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3C=O)cn(C)c2=O)nc1>>C[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cncc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cn(C)c2=O)nc1,,CO,,[BH4-].[Na+],,val
US20060063828A1,COC(=O)c1ccc(C(=O)Cc2cc(-c3cc4ccccc4s3)ccc2OC)cc1>>COc1ccc(-c2cc3ccccc3s2)cc1CC(=O)c1ccc(C(=O)O)cc1,,CO,,C1CCOC1,,val
US20090018122A1,CC(C)(CNc1c([N+](=O)[O-])cnc2ccc(OCc3ccccc3)cc12)NC(=O)OC(C)(C)C>>CC(C)(CNc1c(N)cnc2ccc(OCc3ccccc3)cc12)NC(=O)OC(C)(C)C,[Pt],CC#N,,[H][H],,val
US20060004084A1,COC=Cc1ccc2c(c1)COC2=O.O=C1Cc2ccccc2N1>>COC=Cc1ccc2c(c1)COC2=C1C(=O)Nc2ccccc21,,C1CCOC1,O,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US04721786,CC(CO)Cc1ccc2ccccc2c1.CS(=O)(=O)Cl>>CC(COS(C)(=O)=O)Cc1ccc2ccccc2c1,,c1ccncc1,,,,val
US20140187545A1,COC(=O)CC(=O)OC.Cc1c(Cc2c(N)n[nH]c2N)cccc1C(F)(F)F>>Cc1c(Cc2c(N)nn3c2NC(=O)CC3=O)cccc1C(F)(F)F,,CO,,C[O-].[Na+],,val
US20160096835A1,CCNc1cccnc1.O=S(=O)(Cl)c1ccc(Cl)nc1>>CCN(c1cccnc1)S(=O)(=O)c1ccc(Cl)nc1,,ClCCl,O,CCN(CC)CC,,val
US20080139590A1,COc1cc2ncnc(Cl)c2cc1OC(C)=O.NCc1ccccc1>>COc1cc2ncnc(NCc3ccccc3)c2cc1O,,CC(C)O,,,,val
US20130303551A1,C=C(CC(=O)O)C(=O)O.CCO.C[C@@H](N)c1ccccc1>>CCOC(=O)[C@@H]1CC(=O)N([C@H](C)c2ccccc2)C1,,CCCCCC,CCOC(C)=O,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US05922645,COC(=O)c1ccc(NN)cc1S(=O)(=O)NC(C)(C)C.O=C1CCCC1>>COC(=O)c1ccc(NN=C2CCCC2)cc1S(=O)(=O)NC(C)(C)C,,CO,,,,val
US06503919B1,COc1cc(Nc2cc3ccccc3cc2C(=O)O)c2c(c1)OC(C)(C)C=C2>>COc1cc2c(c3[nH]c4cc5ccccc5cc4c(=O)c13)C=CC(C)(C)O2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160237069A1,CCN1CCCC(N)C1.Cc1cc(O)nc(NC(=N)N(C)c2ccc(Cl)c(Cl)c2)n1.Cl>>Cc1cc(Cl)nc(NC(=N)N(C)c2ccc(Cl)c(Cl)c2)n1.[NH4+].[OH-],,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20090209559A1,CCCC[Sn](CCCC)(CCCC)c1cnc(NC(=O)OC(C)(C)C)s1.Oc1cccc(-c2nc(Br)c3sccc3n2)c1>>Nc1ncc(-c2nc(-c3cccc(O)c3)nc3ccsc23)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(=O)N(C)C,,,,val
US06291460B1,NNc1cc(N2CCCC2)c(Cl)nn1.O=Cc1cccnc1>>Clc1nnc(NN=C2C=CC=NC2)cc1N1CCCC1,,Cl,,,,val
US20030120079A1,CCOC(=O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(=O)c1cccc(C(OC)(OC)c2ccccc2)c1>>CCOC(=O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(C(OC)(OC)c2ccccc2)c1,,CCO,,[BH4-].[Na+],,val
US20060128729A1,CCCc1nn(C)c2c(Cl)nc(-c3ccc(F)cc3)nc12.COc1ccc(N)cc1F>>CCCc1nn(C)c2c(Nc3ccc(OC)c(F)c3)nc(-c3ccc(F)cc3)nc12.Cl,,CC(C)O,,,,val
US20030073850A1,CCS(=O)(=O)Nc1cc(C2CCCCC2)cc2c1CCCC2c1cn(S(=O)(=O)N(C)C)cn1>>CCS(=O)(=O)Nc1cc(C2CCCCC2)cc2c1CCCC2c1c[nH]cn1,,C1CCOC1,,Cl,,val
US20150353565A1,Cn1ncc2c1CCCC2=O>>Cn1ncc2c1CCCC2O,,CCO,,[BH4-].[Na+],,val
US04803280,CCOC(=O)C(S)C(=S)Cc1ccc(OC)cc1.COC(=O)NN>>COC(=O)NNC(=S)Cc1ccc(OC)cc1,,ClCCl,,,,val
US20140194349A1,COC(=O)N[C@@H](CC(N)=O)C(=O)N([C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(c1ccccc1)(c1ccccc1)c1ccccc1>>COC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150158863A1,CCOC(=O)CNc1ncc(C)cc1[N+](=O)[O-]>>Cc1cnc2c(c1)NC(=O)CN2,[Fe],CCO,,Cl,,val
US20130237571A1,CCOC(=O)C1CC1c1ccc(OC)cc1>>CCOC(=O)C1CC1c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,,val
US20140220573A1,Cc1ccc2ccc3ccc(CO)c4ccc1c2c34.O=c1ccn2c(n1)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]12>>Cc1ccc2ccc3ccc(CO[C@@H]4[C@H](O)[C@@H](CO)O[C@H]4n4ccc(=O)[nH]c4=O)c4ccc1c2c34,,CS(C)=O,,C1CCOC1,O=C([O-])O.[Na+],val
US20050154042A1,CCOC(=O)c1c(-c2ccc(F)cc2)c(-c2ccc(F)cc2)cn1C(C)C.Cc1ccnc(N)n1>>Cc1ccnc(NC(=O)c2c(-c3ccc(F)cc3)c(-c3ccc(F)cc3)cn2C(C)C)n1,,C1CCOC1,O,Cl,[H-].[Na+],val
US20080015221A1,C1CCNCC1.O=C1C(Cl)=C(Cl)C(=O)c2ncccc21>>O=C1C(Cl)=C(N2CCCCC2)C(=O)c2ncccc21,,c1ccccc1,,CCN(CC)CC,,val
US20110053976A1,CNC(=O)c1ccc2ncc(C(=O)O)c(Nc3ccc(OC)cc3)c2c1.CO>>CNC(=O)c1ccc2ncc(C(=O)OC)c(Nc3ccc(OC)cc3)c2c1,CN(C)c1ccncc1,CO,,On1nnc2ccccc21,,val
US20150252030A1,Cc1cc(C)c(OCC(=O)[O-])c(-c2cccnc2)c1.NN>>Cc1cc(C)c(OCC(=O)NN)c(-c2cccnc2)c1,,CCO,,O,,val
US20090137581A1,CC(C)(C)OC(=O)NCc1cc2cccc(S(C)(=O)=O)c2nc1-c1cccc(F)c1.Clc1ncnc2nc[nH]c12>>CS(=O)(=O)c1cccc2cc(CNc3ncnc4[nH]cnc34)c(-c3cccc(F)c3)nc12,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20080227797A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@H](NC(=O)c2cc(F)cnc2Nc2ccc(F)c(F)c2)CC1.CCOC(=O)Cl>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3ccc(F)c(F)c3)c2=O)CC1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20050187223A1,CC(N)Cc1cccc(C(C)(C)NC(=O)OC(C)(C)C)c1.CS(=O)(=O)c1nccc(N2CCC(=O)N3CC=C(c4ccccc4)N=C32)n1>>CC(Cc1cccc(C(C)(C)NC(=O)OC(C)(C)C)c1)Nc1nccc(N2CCC(=O)N3CC=C(c4ccccc4)N=C32)n1,,CN1CCCC1=O,,O,,val
US20070213323A1,COc1ccc(COc2ccc(OC)nc2)cc1.ClCc1ccc(Cl)cc1>>COc1ccc(COc2ccc(=O)n(Cc3ccc(Cl)cc3)c2)cc1,,CC#N,,[I-].[Na+],,val
US20070149562A1,O=C(O)C1(c2ccccc2)CC2CCC(C1)N2Cc1ccccc1>>O=C(O)C1(c2ccccc2)CC2CCC(C1)N2,[Pd],CO,,O=C[O-].[NH4+],,val
US05571833,C1CCNC1.COc1ccc2[nH]cc(CC#N)c2c1Cl>>COc1ccc2[nH]cc(CCN3CCCC3)c2c1Cl,[Ni],CO,,,,val
US05977101,COc1ccc(N)c([N+](=O)[O-])c1.O=C(O)CNC(=O)OCc1ccccc1>>COc1ccc(NC(=O)CNC(=O)OCc2ccccc2)c([N+](=O)[O-])c1,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20120225854A1,CC#C[Mg]Br.CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2cccs2)CC1=O>>CC#CC(=O)CN(CCNC(=O)OC(C)(C)C)S(=O)(=O)c1cccs1,,C1CCOC1,,,,val
US20150051171A1,CCOc1cccc(-n2nnn(C)c2=O)c1CBr.Oc1ccn(-c2ccc(F)cc2)n1>>CCOc1cccc(-n2nnn(C)c2=O)c1COc1ccn(-c2ccc(F)cc2)n1,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20150197509A1,CNCC(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)ncn1.O=S(=O)(Cl)c1cccs1>>CN(CC(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)ncn1)S(=O)(=O)c1cccs1,,ClCCl,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US05112847,CC(C)C(CCCCc1ccccc1)C(=O)N1CCC[C@H]1CO>>CC(C)C(CCCCc1ccccc1)C(=O)N1CCC[C@H]1C=O,,CS(C)=O,,CCN(CC)CC,O,val
US20120252865A1,CCOC(=O)c1cc(C)oc1-c1cccc(OC)c1>>COc1cccc(-c2oc(C)cc2C(=O)O)c1,,CCO,O,[Na+].[OH-],,val
US20120184542A1,CC(C)(C)OC(=O)NCCCN.COc1ncc2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1>>COc1ncc2cc(C(=O)Nc3cc(C(=O)NCCCNC(=O)OC(C)(C)C)ccc3Cl)c(=O)[nH]c2n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120309735A1,CC(C)(C)OC(=O)Nc1ncc(-c2cccc(Nc3nccc(C(F)(F)F)n3)c2)s1>>Nc1ncc(-c2cccc(Nc3nccc(C(F)(F)F)n3)c2)s1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120316165A1,CC(C)(C)OC(=O)N1CCOC(c2ccc(NC(=O)Nc3cccc(C#N)c3)c(Cl)c2)C1>>N#Cc1cccc(NC(=O)Nc2ccc(C3CNCCO3)cc2Cl)c1,,CC#N,O,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20140135332A1,C[C@H](OS(C)(=O)=O)c1nc(-c2ccc(C(F)(F)F)cc2)co1.NC(=O)c1c(F)ccc(O)c1F>>C[C@@H](Oc1ccc(F)c(C(N)=O)c1F)c1nc(-c2ccc(C(F)(F)F)cc2)co1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040019210A1,CCN1C(=O)N(c2c(F)c(OC)cc(OC)c2F)Cc2cnc(SC)nc21.O=S(=O)(c1ccccc1)N1OC1c1ccccc1>>CCN1C(=O)N(c2c(F)c(OC)cc(OC)c2F)Cc2cnc(S(C)=O)nc21,,ClC(Cl)Cl,,,,val
US20020045615A1,Nc1nc2ccccc2s1.O=C(Cl)c1ccc(Cl)nc1>>O=C(Nc1nc2ccccc2s1)c1ccc(Cl)nc1,,c1ccncc1,,,,val
US04703052,O=Cc1ccc2c(c1)CCCS2(=O)=O.OCCO>>O=S1(=O)CCCc2cc(C3OCCO3)ccc21,,O,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US05952386,Nc1ccc(OC(F)(F)F)cc1.O=C(O)CCCOc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl>>O=C(CCCOc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl)Nc1ccc(OC(F)(F)F)cc1,,ClCCl,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US06239131B1,COC(=O)c1cc(NC(=O)NC2CN(C(=O)CC(C)(C)C)c3ccc(C)cc3N(CC(=O)c3ccccc3C)C2=O)ccc1C>>Cc1ccc2c(c1)N(CC(=O)c1ccccc1C)C(=O)C(NC(=O)Nc1ccc(C)c(C(=O)O)c1)CN2C(=O)CC(C)(C)C,,C1CCOC1,,O,[Li+].[OH-],val
US20100184809A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(N(C)Cc2ccc(C(=O)O)cc2)c(C(F)(F)F)n1.OCCO>>CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(N(C)Cc2ccc(C(=O)OCCO)cc2)c(C(F)(F)F)n1,,CC#N,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20150152112A1,O=C([O-])O.O=c1cc(-c2cc(Cl)ccc2-n2cnnn2)cc2n1[C@H](c1ncc(-c3ccc(F)nc3)[nH]1)CC2>>O=c1ccc(-c2cnc([C@@H]3CCc4cc(-c5cc(Cl)ccc5-n5cnnn5)cc(=O)n43)[nH]2)c[nH]1,,COCCOC,,Cl,,val
US20040204447A1,CC=O.Nc1ccc(-c2ccc(-c3cc4cccc(Cl)c4c(=O)n3Cc3ccc(F)cc3F)s2)cc1C(F)(F)F>>CCNc1ccc(-c2ccc(-c3cc4cccc(Cl)c4c(=O)n3Cc3ccc(F)cc3F)s2)cc1C(F)(F)F,CC(=O)O,Cc1ccccc1,,,,val
US20090136513A1,CN1CCNCC1.COC(=O)c1ccc(F)c([N+](=O)[O-])c1>>COC(=O)c1ccc(N2CCN(C)CC2)c([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05281612,CC(=O)C1CC(=O)N(Cc2ccccc2)C1.NO>>CC(=NO)C1CC(=O)N(Cc2ccccc2)C1,,c1ccncc1,,Cl,,val
US20060173043A1,COC(=O)CCC1=CCN(Cc2ccc(OC)cc2OC)C1=O>>COC(=O)CCC1=CCNC1=O,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US05914328,CC(C)(C)OC(=O)N1CC[C@H]1CO.Oc1ccc(Cl)nc1>>CC(C)(C)OC(=O)N1CC[C@H]1COc1ccc(Cl)nc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04668831,CC(C)(C)c1cc(O)ccc1Br.S=C(Cl)Cl>>CC(C)(C)c1cc(OC(=S)Cl)ccc1Br,,ClC(Cl)Cl,,[Na+].[OH-],,val
US20160207926A1,CC(C)N1CC(NC(=O)OC(C)(C)C)C2(CC2)C1.ClCCl.O=C(O)C(F)(F)F>>C=O.CC(C)N1CC(N)C2(CC2)C1,,ClCCl,,O,,val
US20150232435A1,CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.O=C(n1ccnc1)n1ccnc1.O=S(=O)(c1ccccc1)N1CCNCC1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCN(S(=O)(=O)c4ccccc4)CC3)CC2)cc(C(F)(F)F)n1,,CO,ClC(Cl)Cl,,,val
US20100160369A1,CC(=CC(=O)OC(C)(C)C)c1ccc(C#N)c(C)c1>>Cc1cc(C(C)CC(=O)OC(C)(C)C)ccc1C#N,[Pd],CCO,,,,val
US20020128301A1,CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)OCCOc1ccc(C(=O)O)c(CI)c1>>CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)OCCOc1ccc(C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090069430A1,CO.COc1ccc(C(=O)O)c(O)c1>>COC(=O)c1ccc(OC)cc1O,,O=S(=O)(O)O,,,,val
US20070124152A1,CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN(C)C(C)=O)c1=O.CN>>CNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN(C)C(C)=O)c1=O,,CCO,,,,val
US20050065033A1,CS(=O)(=O)Cl.OCCCCC1=CC1>>CS(=O)(=O)OCCCCC1=CC1,,ClCCl,,CCN(CC)CC,O,val
US20010027196A1,CS(=O)c1nc(N)nc(Cl)c1C#N.SCCc1ccccn1>>N#Cc1c(Cl)nc(N)nc1SCCc1ccccn1,,COCCOC,,C1CCC2=NCCCN2CC1,O,val
US20070254925A1,C=C(C)c1nc(NC(=O)c2c(F)cccc2F)sc1-c1cccc(C(F)(F)F)c1>>CC(C)c1nc(NC(=O)c2c(F)cccc2F)sc1-c1cccc(C(F)(F)F)c1,[Pd],CCOC(C)=O,,[H][H],,val
US20120058989A1,CCOC(=O)c1cn(C2CC2)c2c(C#CC[C@@H]3C[C@H](NC(=O)OC(C)(C)C)CN3C(=O)OC(C)(C)C)c(F)c(F)cc2c1=O>>CCOC(=O)c1cn(C2CC2)c2c(/C=C\C[C@@H]3C[C@H](NC(=O)OC(C)(C)C)CN3C(=O)OC(C)(C)C)c(F)c(F)cc2c1=O,,CCO,,,,val
US06022906,CC(C)(C(=O)c1ccc(F)cc1)N1CCOCC1.SCCCS>>CC(C)(C(=O)c1ccc(SCCCS)cc1)N1CCOCC1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US05756507,CON(C)C(=O)C1CC1C.Cc1cc(C)cc(Br)c1>>Cc1cc(C)cc(C(=O)C2CC2C)c1,,CCCCCC,,[Li]CCCC,,val
US04005217,CNC.O=C(CCl)Nc1ccccc1[N+](=O)[O-]>>CN(C)CC(=O)Nc1ccccc1[N+](=O)[O-],,CCO,,,,val
US20150166480A1,Brc1ccc(OCC2CCNCC2)cc1.C1CC2(C1)CO2>>OC1(CN2CCC(COc3ccc(Br)cc3)CC2)CCC1,,CCO,O,CCN(CC)CC,,val
US20060008670A1,C1=CCC(c2ncc[nH]2)C=C1.OB(O)c1ccccc1>>c1ccc(-c2nccn2-c2ccccc2)cc1,,ClCCl,,c1ccncc1,,val
US20020107251A1,CCOP(=O)(Cc1ccccc1)OCC.O=Cc1cccc([N+](=O)[O-])c1>>O=[N+]([O-])c1cccc(/C=C/c2ccccc2)c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20140031342A1,CC(O)(CCO)COc1ccc(N2CCC(CCc3ccc(OC(F)(F)F)cc3)CC2)cc1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCCC(C)(O)COc2ccc(N3CCC(CCc4ccc(OC(F)(F)F)cc4)CC3)cc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20040110767A1,O=C(Cl)c1c(Cl)cc(Cl)cc1Cl.c1cc(CNc2ccc(OCCN3CCCC3)cc2)cc(OC2CCCCO2)c1>>O=C(c1c(Cl)cc(Cl)cc1Cl)N(Cc1cccc(OC2CCCCO2)c1)c1ccc(OCCN2CCCC2)cc1,,ClCCl,,CCN(CC)CC,,val
US04971982,COC(=O)c1ccc2c(c1)C(c1ccccn1)=CC(C)(C)O2.O=C(OO)c1cccc(Cl)c1>>COC(=O)c1ccc2c(c1)C(c1cccc[n+]1[O-])=CC(C)(C)O2,,ClCCl,,,,val
US20110251173A1,C[C@@H]1CN(c2ccc(-c3c(F)cccc3F)cc2)C(=O)c2c(Cl)ncnc2O1.N>>C[C@@H]1CN(c2ccc(-c3c(F)cccc3F)cc2)C(=O)c2c(N)ncnc2O1,,C1COCCO1,,,,val
US20020052322A1,C1CCNC1.C[C@H](NC(=O)[C@H](C)NC(=O)Cc1cc(F)cc(F)c1)C(=O)O>>C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](C)C(=O)N1CCCC1,,CO,ClC(Cl)Cl,,,val
US20020160996A1,COc1ccc(C(=O)Nc2c(C)c(C)c3c(c2C)C(c2ccc(F)cc2)C(C)(C)O3)cc1>>COc1ccc(CNc2c(C)c(C)c3c(c2C)C(c2ccc(F)cc2)C(C)(C)O3)cc1,,CO,,,,val
US20150239847A1,CC(=O)OC(C)=O.Nc1cc(F)c(-n2ccc(NC(=O)c3ccccc3C(F)(F)F)n2)c(F)c1>>CC(=O)Nc1cc(F)c(-n2ccc(NC(=O)c3ccccc3C(F)(F)F)n2)c(F)c1,,O,,,,val
US20130053308A1,CS(=O)c1nc(N)cc(Cl)n1.O=C1CCC(=O)N1Br>>CS(=O)c1nc(N)c(Br)c(Cl)n1,,CN(C)C=O,,,,val
US20140275030A1,O=C1CCC(=O)N1Br.O=c1[nH]c2cccc3c2n1C(C1CCCCN1)CO3>>O=c1[nH]c2ccc(Br)c3c2n1C(C1CCCCN1)CO3,,CCOC(C)=O,,CC(=O)O,,val
US20020045654A1,Cc1cc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)c(F)c2)ccc1O.[Cl-]>>Cc1cc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)c(F)c2)cc(Cl)c1O,,ClCCl,,O,,val
US04044141,CCO.COC(=O)C1=C(C)NC(C)=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1c1ccccc1[N+](=O)[O-]>>C/C(N)=C/C(=O)OCc1ccc([N+](=O)[O-])cc1.COC(=O)CC(=O)/C=C/c1ccccc1[N+](=O)[O-],,CCO,,,,val
US20130217666A1,ON=C1c2cc(Br)c(F)cc2C2CC1C2>>O=C1NC2CC(C2)c2cc(F)c(Br)cc21,,C1COCCO1,,O=S(Cl)Cl,,val
US20120029226A1,C[C@@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c1.c1ccc(CNCc2ccccc2)cc1>>C[C@@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c1.c1ccc(CNCc2ccccc2)cc1,,CCO,,,,val
US20060148811A1,COc1ccc(C(=O)CBr)cc1.Cl.Cl.c1ccc(CN2CCNCC2)cc1>>COc1ccc(C(=O)CN2CCN(Cc3ccccc3)CC2)cc1.Cl.Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130252936A1,FC(F)(F)CN1CCNCC1.O=C(O)Cn1nc(-c2ccccc2)c2c(Cl)c(-c3ccccc3)nnc21>>O=C(Cn1nc(-c2ccccc2)c2c(Cl)c(-c3ccccc3)nnc21)N1CCN(CC(F)(F)F)CC1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140275111A1,CN(C)CCOc1ncc(N)cc1C(F)(F)F.O=C(O)Cc1ccc(Br)cc1F>>CN(C)CCOc1ncc(NC(=O)Cc2ccc(Br)cc2F)cc1C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100048636A1,CCC([C@H](CC1CCCCC1)NC(=O)OC(C)(C)C)N(C)C(=O)OCC[Si](C)(C)C>>CCC([C@@H](N)CC1CCCCC1)N(C)C(=O)OCC[Si](C)(C)C,,CCO,CCOCC,,,val
US20050171122A1,CCC(Br)c1nc2sc(Br)nc2c(=O)n1Cc1ccccc1.CN(C)CCN>>CCC(NCCN(C)C)c1nc2sc(Br)nc2c(=O)n1Cc1ccccc1,,CCO,,,,val
US20060100201A1,CC1CCN(c2cc(C3=CCN(C(=O)OC(C)(C)C)CC3)ccc2[N+](=O)[O-])CC1>>CC1CCN(c2cc(C3CCN(C(=O)OC(C)(C)C)CC3)ccc2N)CC1,[Pd],CO,,,,val
US20100137245A1,COP(=O)(OC)C(=[N+]=[N-])C(C)=O.Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C=O)cs2)CC1>>C#Cc1csc(C2CCN(C(=O)Cn3nc(C(F)(F)F)cc3C)CC2)n1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20060258666A1,CC1(C)CC=C(c2ncccc2[N+](=O)[O-])CC1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>N#CCc1ccc(N)c(C2=CCCCC2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20090030013A1,CC(=O)Nc1cc(O)c(Br)cc1Br>>Nc1cc(O)c(Br)cc1Br,,Cl,O,CC(=O)[O-].[Na+],,val
US20060135522A1,COc1cccc2c1Sc1cc(-c3cccnc3)ccc1C2C1CCN(C(=O)OC(C)(C)C)CC1>>COc1cccc2c1Sc1cc(-c3cccnc3)ccc1C2C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04486588,C(=CN1CCOCC1)c1ccccc1.CCOC(=O)c1c(C)cc(=O)oc1C>>CCOC(=O)c1c(C)ccc(-c2ccccc2)c1C,,Cc1ccccc1,,C1COCCN1,,val
US20010039347A1,CCC(O)CCC(=O)NCc1ccc(OC)cc1>>CCC(O)CCCNCc1ccc(OC)cc1,,C1CCOC1,,CC(=O)O,[BH4-].[Na+],val
US20040209921A1,CC(=O)OC(C)(C)c1cccnc1C.O=[Se]=O>>CC(=O)OC(C)(C)c1cccnc1C=O,,C1COCCO1,O,,,val
US04888332,O=C(Cl)c1ccc2c(c1)OCO2.O=C(O)/C(=N\O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>O=C(O)/C(=N\OC(=O)c1ccc2c(c1)OCO2)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,ClCCl,,CCN(CC)CC,,val
US20020086891A1,CS(=O)(=O)Cl.OCCCc1ccc2c(-c3ccc(C(F)(F)F)cc3)nsc2c1>>CS(=O)(=O)OCCCc1ccc2c(-c3ccc(C(F)(F)F)cc3)nsc2c1,,ClCCl,,CCN(CC)CC,,val
US20120083488A1,CC(C)(C)OC(=O)N1CC=C(c2ccc3c(c2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)CC1>>CC(C)(C)OC(=O)N1CCC(c2ccc3c(c2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)CC1,[Pd],C1CCOC1,CO,,,val
US20090124609A1,CC(NC(=O)OC(C)(C)C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1Cl.COc1ccc2c(OCc3nnc4ccc(Cl)nn34)ccnc2c1>>COc1ccc2c(OCc3nnc4ccc(-c5ccc(C(C)NC(=O)OC(C)(C)C)c(Cl)c5)nn34)ccnc2c1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070049574A1,COC(=O)CC(=O)CCc1ccc(F)cc1.NNc1ccc(F)cc1>>O=C1CC(CCc2ccc(F)cc2)=NN1c1ccc(F)cc1,,CC(=O)O,O,CCOC(C)=O,Cl,val
US20130143907A1,C[O-].Cc1c(F)cnc(Cl)c1Br>>COc1ncc(F)c(C)c1Br,,O,,CN(C)C=O,,val
US20080214553A1,C1CCNCC1.CC(C)NC(=O)Cn1c(-c2ccc(F)c(Cl)c2)nc2ccc(OCCCCl)cc2c1=O>>CC(C)NC(=O)Cn1c(-c2ccc(F)c(Cl)c2)nc2ccc(OCCCN3CCCCC3)cc2c1=O,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20070213336A1,CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)OC)cc2O)c1.CCCCI>>CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)OC)cc2OCCCC)c1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160002224A1,C[Si](C)(C)CCOCn1c(Cl)cc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc21.O=C(O)c1cccc(B(O)O)c1>>C[Si](C)(C)CCOCn1c(-c2cccc(C(=O)O)c2)cc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,O,O=C([O-])[O-].[Na+].[Na+],,val
US20110105502A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Oc1ccc2c(c1)C(C1(c3ccccn3)CCC1)NCC2>>CC(C)(C)OC(=O)N1CCc2ccc(O)cc2C1C1(c2ccccn2)CCC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090005353A1,Cc1ccc(S(=O)(=O)OCCNC2=C(c3ccccc3)S(=O)(=O)N(C(C)(C)C)C2=O)cc1.Oc1cccnc1>>CC(C)(C)N1C(=O)C(NCCOc2cccnc2)=C(c2ccccc2)S1(=O)=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US06096930,CCC(=O)OC(=O)CC.CCC1(C)Cc2c(C)c(Cl)c(C3CC(=O)CC(=O)C3)c(C)c2C1.CN(C)c1ccccn1>>CCON=C(CC)C1=C(O)CC(c2c(C)c3c(c(C)c2Cl)CC(C)(CC)C3)CC1=O,,Cc1ccccc1,,,,val
US05741785,CCOC(=O)c1nc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n2c1Cn1ccnc1C>>Cc1nccn1Cc1c(C(=O)O)nc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n12,,Br,,,,val
US05721245,CC(=O)OCC1CCn2c(c(C3=C(c4cn(C)c5ccccc45)C(=O)OC3=O)c3ccccc32)C1.N>>Cn1cc(C2=C(c3c4n(c5ccccc35)CCC(CO)C4)C(=O)NC2=O)c2ccccc21,,CN(C)C=O,,,,val
US20060003995A1,C1=Cc2ccccc2NN=C1.O=C(O)c1ncn2c1CN=C(c1ccccc1F)c1cc(Br)ccc1-2.O=C(OCC(F)(F)F)c1ncn2c1CN=C(c1ccccc1F)c1cc(Br)ccc1-2>>CC1N=C(c2ccccc2)c2cc(Br)ccc2NC1=O,,CCOC(C)=O,,[Br-].[K+],,val
US03997535,Cc1cc2ncc(C(=O)O)nc2cc1C.Nc1nnn[nH]1>>Cc1cc2ncc(C(=O)Nc3nnn[nH]3)nc2cc1C,,CN(C)C=O,,,,val
US20150175604A1,Cc1cc2c(ccc3nnc(C)n32)n1Cc1cccc([N+](=O)[O-])c1>>Cc1cc2c(ccc3nnc(C)n32)n1Cc1cccc(N)c1,[Pd],CO,,[H][H],,val
US20080312248A1,CCN1CCC(c2ccc([N+](=O)[O-])cc2)CC1>>CCN1CCC(c2ccc(N)cc2)CC1,[Pd],CCO,,,,val
US20130317001A1,CC(C)(C)OC(=O)c1cc(Cl)c(F)cc1F.C[C@@H]1CC[C@@H](CO)CC1>>C[C@@H]1CC[C@@H](COc2cc(F)c(C(=O)OC(C)(C)C)cc2Cl)CC1,,CS(C)=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100048636A1,CC(C)(C)OC(=O)N1CCC[C@@H](C(=O)c2cccc(Cl)c2)C1>>CC(C)(C)OC(=O)N1CCC[C@@H](C(O)c2cccc(Cl)c2)C1,,CCO,,[BH4-].[Na+],,val
US20090131413A1,O=C1CNCCN1.O=[N+]([O-])c1ccc(F)cc1>>O=C1CN(c2ccc([N+](=O)[O-])cc2)CCN1,,CN(C)C=O,ClC(Cl)Cl,O=C([O-])[O-].[K+].[K+],,val
US20100305096A1,C1CC(C2COC2)CCN1.Cn1c(C=O)nc2c(N3CCOCC3)nc(Cl)nc21>>Cn1c(CN2CCC(C3COC3)CC2)nc2c(N3CCOCC3)nc(Cl)nc21,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080214546A1,Nc1ccc(F)c(Cl)c1.O=C(O)c1cc(OCCCBr)no1>>O=C(Nc1ccc(F)c(Cl)c1)c1cc(OCCCBr)no1,,Cc1ccccc1,c1ccncc1,O=P(Cl)(Cl)Cl,,val
US20110201605A1,Nc1nc2c(-c3ccc(F)c(F)c3)cc(F)cn2n1>>Nc1nc2n(n1)CC(F)CC2c1ccc(F)c(F)c1,[Pd],CCO,,Cl,,val
US20100286145A1,CI.COC(=O)c1cc(NS(C)(=O)=O)cc(C(=O)OC)c1>>COC(=O)c1cc(C(=O)OC)cc(N(C)S(C)(=O)=O)c1,,CN(C)C=O,,[H-].[Na+],,val
US20140051679A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1cc(Br)ccc1OC1CCN(C)CC1>>COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1OC1CCN(C)CC1,,CN(C)C=O,,CC(=O)[O-].[K+],,val
US20060014777A1,CC(C)OC(=O)c1c(C=CC(=O)N2[C@H]3C[C@H]4CC[C@@]3(CS2(=O)=O)C4(C)C)cccc1C(F)(F)F.COCN(Cc1ccccc1)C[Si](C)(C)C.NCc1ccccc1>>CC(C)OC(=O)c1c(C2CN(Cc3ccccc3)CC2C(=O)N2C3CC4CCC3(CS2(=O)=O)C4(C)C)cccc1C(F)(F)F,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,,val
US06100272,C=CCBr.Cc1cc(N2CCCC2=O)ccc1-c1ccc(C(=O)N2CCc3cc4c(cc32)C2(CCNCC2)CO4)cc1>>C=CCN1CCC2(CC1)COc1cc3c(cc12)N(C(=O)c1ccc(-c2ccc(N4CCCC4=O)cc2C)cc1)CC3,,CN(C)C=O,,CCO,,val
US20060258627A1,CC(C)CN(CC(O)C(Cc1ccccc1)NC(=O)OC1COC2OCCC12)S(=O)(=O)c1ccc2occ(CN)c2c1.O=C(Cl)c1ccccc1>>CC(C)CN(CC(O)C(Cc1ccccc1)NC(=O)OC1COC2OCCC12)S(=O)(=O)c1ccc2occ(CNC(=O)c3ccccc3)c2c1,,C1CCOC1,,CCN(CC)CC,,val
US06919328B1,CCI.NC(=S)Nc1ccc2c(c1)C(=O)Nc1ccccc1N2>>CCSC(=N)Nc1ccc2c(c1)C(=O)Nc1ccccc1N2,,CS(C)=O,,,,val
US20030181468A1,ClP(Cl)(Cl)(Cl)Cl.N#CC(C#N)=C(O)c1ccc([N+](=O)[O-])cc1>>N#CC(C#N)=C(Cl)c1ccc([N+](=O)[O-])cc1,,ClCCl,,,,val
US20080167310A1,COC(=O)C[C@H](N)C(=O)OC.O=C(Cl)c1ccccc1>>COC(=O)CC(NC(=O)c1ccccc1)C(=O)OC,,ClCCl,O,CCN(CC)CC,,val
US20160176850A1,COc1ccnc2c1c(C1CCN(C(=O)OC(C)(C)C)CC1)nn2COCC[Si](C)(C)C>>COc1ccnc2c1c(C1CCNCC1)nn2CO,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160009720A1,CC(C)(C)OC(=O)N1CC[C@@H](CO)C1.Nc1nc(Cl)c(Br)nc1Br>>CC(C)(C)OC(=O)N1CC[C@@H](COc2nc(Br)c(Cl)nc2N)C1,,C1COCCO1,,[Na+].[OH-],,val
US20080045528A1,CC(C)C[C@@H](N)CO.CS(=O)c1nc2ccc(Oc3ccnc(Cl)c3)cc2s1>>CC(C)C[C@H](CO)Nc1nc2ccc(Oc3ccnc(Cl)c3)cc2s1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20050234096A1,CCOC(=O)COc1cc(C)ccc1C.O=S(=O)(O)Cl>>CCOC(=O)COc1cc(C)c(S(=O)(=O)Cl)cc1C,,ClC(Cl)Cl,,,,val
US06187802B1,Br.O=C(CSC1=NCCCN1)C1(c2ccc(Cl)c(Cl)c2)CCC1>>Br.Clc1ccc(C2(C3=CSC4=NCCCN34)CCC2)cc1Cl,,CC(=O)O,,,,val
US08163479B2,NCCCc1nc2c(OCc3ccc(CNC(=O)C(F)(F)F)cc3)nc(N)nc2[nH]1.O=C(CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21)NCCCCCC(=O)ON1C(=O)CCC1=O>>Nc1nc(OCc2ccc(CNC(=O)C(F)(F)F)cc2)c2nc(CCC(N)C(=O)CCCCCNC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@@H]43)[nH]c2n1,,CN(C)C=O,,,,val
US20060165637A1,CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)O.CCCCO>>CCCCOC(=O)CC(C)CCCC(C)CCCC(C)CCCC(C)C,,CCCCO,,O=S(=O)(O)O,,val
US20100099728A1,N#Cc1cccc(CN2C(=O)C3(COc4cc5c(cc43)CCO5)c3ccccc32)c1.NO>>NC(=NO)c1cccc(CN2C(=O)C3(COc4cc5c(cc43)CCO5)c3ccccc32)c1,,CS(C)=O,,,,val
US20080242665A1,CN.Cc1c(C=O)sc2c(N3CCOCC3)nc(Cl)nc12>>CNCc1sc2c(N3CCOCC3)nc(Cl)nc2c1C,,Cc1ccccc1,O,C1CCOC1,,val
US20040010006A1,C1=C(c2c[nH]c3ccccc23)CCNC1.Cc1ccc(S(=O)(=O)OC[C@H]2COc3ccc4[nH]c(C(F)(F)F)nc4c3O2)cc1>>FC(F)(F)c1nc2c3c(ccc2[nH]1)OCC(CN1CC=C(c2c[nH]c4ccccc24)CC1)O3,,CCOC(C)=O,CS(C)=O,,,val
US20080085890A1,CON=Cc1ccc(OC)c(F)c1.Cl>>COc1ccc(CN)cc1F.Cl,[Pd],CCO,,,,val
US20120165309A1,N[C@@H]1CC[C@@H](Nc2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1.O=C(Cl)CBr>>O=C(CBr)N[C@@H]1CC[C@@H](Nc2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1,,ClCCl,,CCN(CC)CC,O,val
US20090233879A1,C1COCCN1.CC(=O)OC1(C)[C@@H](COC(=O)c2ccccc2)OC(n2cnc3c(Cl)ncnc32)[C@]1(C)F>>CC(=O)OC1(C)[C@@H](COC(=O)c2ccccc2)OC(n2cnc3c(N4CCOCC4)ncnc32)[C@]1(C)F,,CCO,,O,,val
US20080221148A1,OC(c1cccc(OCc2ccc(Cl)cc2F)c1OCCF)c1c[nH]c2ncccc12>>O=C(c1cccc(OCc2ccc(Cl)cc2F)c1OCCF)c1c[nH]c2ncccc12,,C1CCOC1,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20040058964A1,CCOC(=O)c1cnc(Cn2c(C)cc(OCc3ccc(F)cc3F)c(Cl)c2=O)cn1>>Cc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1Cc1cnc(CO)cn1,,C1CCOC1,CC(C)(C)O,[BH4-].[Na+],,val
US20050020830A1,C=CCN1CC2CC(C1)c1cccc(O)c1C2=O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>C=CCN1CC2CC(C1)c1cccc(OS(=O)(=O)C(F)(F)F)c1C2=O,,ClCCl,,Cl,c1ccncc1,val
US04904694,COC(=O)c1cc(OC)c(OC)c(OC)c1-c1c(C(=O)OC)cc2c(c1OC)OCO2>>COc1cc(C(=O)O)c(-c2c(C(=O)O)cc3c(c2OC)OCO3)c(OC)c1OC,,CO,,[Na+].[OH-],,val
US20050209260A1,COc1cc2c(C)cn(C)c2cc1C(F)(F)F>>Cc1cn(C)c2cc(C(F)(F)F)c(O)cc12,,ClCCl,,BrB(Br)Br,,val
US20060287362A1,O=C(Cl)C(=O)Cl.O=C(O)C(=O)c1cccs1>>O=C(Cl)C(=O)c1cccs1,,ClCCl,,CN(C)C=O,,val
US20110021527A1,CCC[Mg]Br.CON(C)C(=O)C(Cc1ccc(Br)cc1)NC(=O)OC(C)(C)C>>CCCC(=O)C(Cc1ccc(Br)cc1)NC(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20140331895A1,C=CC(=O)OCC.COCCOCCO>>CCOC(=O)CCOCCOCCOC,,C1CCOC1,,CC(=O)O,[H-].[Na+],val
US20120035214A1,BrCc1ccc(Br)cc1.COCC(F)(F)CO>>COCC(F)(F)COCc1ccc(Br)cc1,,C1CCOC1,,[H-].[Na+],,val
US20090036492A1,COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.O=Cc1ccc(Oc2ccc(Cl)cc2Cl)c2ccccc12>>COc1cc(O)c2c(c1C(=O)NCc1ccc(Oc3ccc(Cl)cc3Cl)c3ccccc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,,CC#N,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US06063806,CCCCCCCCI.CCOC(=O)Cc1c(C)c(NC(=O)C(C)(C)C)c2[nH]ccc2c1C>>CCCCCCCCn1ccc2c(C)c(CC(=O)OCC)c(C)c(NC(=O)C(C)(C)C)c21,,CN(C)C=O,,[H-].[Na+],,val
US20160122317A1,COC(=O)C(=C1CCN(C(=O)OC(C)(C)C)CC1)c1ccc(Cl)cc1.Cl>>COC(=O)C(=C1CCNCC1)c1ccc(Cl)cc1.Cl,,C1COCCO1,,,,val
US20080227839A1,CC(C)CN.O=[N+]([O-])c1ccc(Cl)cc1F>>CC(C)CNc1cc(Cl)ccc1[N+](=O)[O-],,C1CCOC1,,O,O=C([O-])[O-].[K+].[K+],val
US08044069B2,O=C(O)CN1CCCC(c2ccccc2)(c2ccccc2)C1=O.[H]/N=C(/Cc1ccc(Cl)cc1)NO>>O=C1N(Cc2nc(Cc3ccc(Cl)cc3)no2)CCCC1(c1ccccc1)c1ccccc1,,CC(Cl)Cl,,CCN=C=NCCCN(C)C,Cl,val
US20100286145A1,CI.COC(OC)c1cc(NC(=O)OC(C)(C)C)cc(C(F)(F)F)c1>>COC(OC)c1cc(N(C)C(=O)OC(C)(C)C)cc(C(F)(F)F)c1,,CN(C)C=O,,[H-].[Na+],,val
US20070088018A1,CNC1CCOC1.O=C(O)c1ccc(S(=O)(=O)n2cc(-c3ccccc3)c3ccccc32)cc1>>O=C(NCC1CCOC1)c1ccc(S(=O)(=O)n2cc(-c3ccccc3)c3ccccc32)cc1,,ClCCl,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US05872137,Fc1ccc(CBr)cc1Oc1ccccc1.O=C(Oc1cc(Cl)c(O)c(Cl)c1)c1ccccc1>>O=C(Oc1cc(Cl)c(OCc2ccc(F)c(Oc3ccccc3)c2)c(Cl)c1)c1ccccc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20120015952A1,O=C(NC1=CC(=O)C2OC2C1=O)c1cccnc1O>>O=C(NC1=CC(=O)C2OC2C1O)c1cccnc1O,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04900352,COc1cc(OC)nc(Oc2c(Cl)cc(Cl)cc2C(OC)OC)n1>>COc1cc(OC)nc(Oc2c(Cl)cc(Cl)cc2C=O)n1,,CC(=O)O,,Cl,O,val
US20150376225A1,C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]12>>C[C@]12CCC(=O)C=C1CCC1C2[C@@H](O)C[C@@]2(C)C1CC[C@]2(O)C(=O)O,,C1CCOC1,O,CO,,val
US20080171754A1,C=C(OCC)c1cncc(NC(C)=O)c1>>CC(=O)Nc1cncc(C(C)=O)c1,,CC(C)=O,,Cl,O=C([O-])O.[Na+],val
US20100022550A1,N#Cc1ccc2[nH]c3c(c2c1)CC(NC(=O)OCc1ccccc1)CC3>>N#Cc1ccc2[nH]c3c(c2c1)C[C@H](NC(=O)OCc1ccccc1)CC3,,CO,ClC(Cl)Cl,,,val
US20120264737A1,CCc1nnc(-c2cc(C(=O)OC)c(C)cc2C2CCC2)[nH]1.C[Si](C)(C)CC=[N+]=[N-]>>CCC1NC(c2cc(C(=O)OC)c(C)cc2C2CCC2)=NN1C,,CO,ClCCl,,,val
US20150225365A1,CN=C=O.Fc1cncc(-c2ccc3c(c2)CCN3)c1>>CNC(=O)N1CCc2cc(-c3cncc(F)c3)ccc21,,ClCCl,,,,val
US20160221945A1,C[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H](C(=O)NCc2ccnc(-c3cnc(C(F)(F)F)nc3)c2)N1C(=O)OC(C)(C)C>>C[C@H]1[C@@H](O)C[C@@H](C(=O)NCc2ccnc(-c3cnc(C(F)(F)F)nc3)c2)N1C(=O)OC(C)(C)C,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05616596,Brc1cccs1.Fc1ccc(CBr)cc1>>Fc1ccc(Cc2ccc(Br)s2)cc1,,C1CCOC1,,Cl,CC(C)[N-]C(C)C.[Li+],val
US06310070B1,COc1ccc(-c2nc3ncn(Cc4ccccc4)c3c(=O)[nH]2)cc1OC>>O=c1[nH]c(-c2ccc(O)c(O)c2)nc2ncn(Cc3ccccc3)c12,,CC(=O)O,,Br,,val
US20080227995A1,CC(=O)O.Cc1cc(C#N)ccc1NS(C)(=O)=O>>CC(=O)[O-].Cc1cc(C[NH3+])ccc1NS(C)(=O)=O,[Pd],CO,,,,val
US07649009B2,COC(=O)c1ccc(Cn2nc(-c3cc(F)c(F)c(F)c3)cc2C(=O)OC(C)(C)C)cc1>>COC(=O)c1ccc(Cn2nc(-c3cc(F)c(F)c(F)c3)cc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060089367A1,CCC(=O)Cl.Fc1cc2nc(COc3ccccc3)n(Cc3ccc(Cl)cc3)c2cc1N1CCNCC1>>CCC(=O)N1CCN(c2cc3c(cc2F)nc(COc2ccccc2)n3Cc2ccc(Cl)cc2)CC1,,ClCCl,,,,val
US20100280268A1,CCCCNc1cc(Oc2ccc(NS(=O)(=O)c3ccc(C)cc3)c(C(=O)OC)c2)ccc1N.Cc1ccc(S(=O)(=O)Cl)cc1>>CCCCNc1cc(Oc2ccc(NS(=O)(=O)c3ccc(C)cc3)c(C(=O)OC)c2)ccc1NS(=O)(=O)c1ccc(C)cc1,,ClCCl,,c1ccncc1,,val
US20030114457A1,COC(=O)CC(C(=O)OC)c1cc(C=O)c(O)c(-c2cccc([N+](=O)[O-])c2)c1>>O=Cc1cc(C(CC(=O)O)C(=O)O)cc(-c2cccc([N+](=O)[O-])c2)c1O,,CC#N,,Cl,,val
US20110105447A1,Cc1ncncc1C(=O)Nc1ccc(-n2nc(C3CC3)cc2C2CC2)nc1.Cl>>Cc1ncncc1C(=O)Nc1ccc(-n2nc(C3CC3)cc2C2CC2)nc1.Cl,,C1CCOC1,CCOCC,,,val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.Cc1nc2ncccc2cc1O>>COc1cc2nccc(Oc3cc4cccnc4nc3C)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,O,,val
US20110021537A1,CCCOC(=O)N1CCN(C(=O)C(NC(=O)OCc2ccccc2)C(C)F)CC1>>CCCOC(=O)N1CCN(C(=O)C(N)C(C)F)CC1,[Pd],CCO,,,,val
US05776941,COC(=O)Cc1c(Cl)nc(C)nc1SC.N#Cc1ccccc1Oc1cccc(O)c1>>COC(=O)Cc1c(Oc2cccc(Oc3ccccc3C#N)c2)nc(C)nc1SC,I[Cu]I,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20020103371A1,NC(=NO)C1CC1.O=C(O)CN1C(=O)c2ccccc2C1=O>>O=C1c2ccccc2C(=O)N1Cc1nc(C2CC2)no1,,CN(C)C=O,,O,O=C(n1ccnc1)n1ccnc1,val
US20120258982A1,CC(=O)c1cccnc1Nc1ccccc1.COC(=O)c1ccc(C=O)c(OC)c1>>COC(=O)c1ccc(/C=C/C(=O)c2cccnc2Nc2ccccc2)c(OC)c1,,CO,O,Cl,C[O-].[Na+],val
US20100190825A1,CO[C@@H]1CC[C@@H](N2CCC(Nc3cc(C)c(F)cc3[N+](=O)[O-])CC2)CC1>>CO[C@@H]1CC[C@@H](N2CCC(Nc3cc(C)c(F)cc3N)CC2)CC1,[Ni],CCO,,NN,O,val
US06127354,CN(CCc1ccccc1N)C(=O)OC(C)(C)C.CS(=O)(=O)Cl>>CN(CCc1ccccc1NS(C)(=O)=O)C(=O)OC(C)(C)C,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20150126523A1,FC(F)(F)CNCCCl.O=C(Cl)Oc1ccccc1>>O=C(Oc1ccccc1)N(CCCl)CC(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20110015157A1,CCNCC.C[C@@H](c1ccc(-c2ccc(C(=O)O)nc2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O>>CCNC(=O)c1ccc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20060058370A1,CC(=O)c1ccc(O)c(C(C)(C)C)c1.O=C1CCC(=O)N1Br>>CC(=O)c1cc(Br)c(O)c(C(C)(C)C)c1,,CC#N,,,,val
US20110263557A1,CCc1cnc(N2CCC(Oc3ccc(C(=O)OC)cc3Cl)CC2)nc1>>CCc1cnc(N2CCC(Oc3ccc(CO)cc3Cl)CC2)nc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04013762,C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43CO)[C@@H]1CCC2=O.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43COC(=O)C34CC5CC(CC(C5)C3)C4)[C@@H]1CCC2=O,,Cc1ccccc1,,c1ccncc1,,val
US20040006065A1,C=CCN(C(=O)OCc1ccccc1)c1cnc2n(c1=O)[C@H](C(=O)Nc1ccccc1)CC2C.CC(C)(C)OC(=O)CBr>>C=CCN(C(=O)OCc1ccccc1)c1cnc2n(c1=O)[C@@H](C(=O)Nc1ccccc1)C[C@@]2(C)CC(=O)OC(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20050004211A1,C#C[Si](C)(C)C.CCCCC#C/C=C\Cl>>CCCCC#CC=CC#C[Si](C)(C)C,[Pd],,,,,val
US20080312226A1,Cc1onc(-c2ccccc2)c1N=C=O.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>Cc1onc(-c2ccccc2)c1NC(=O)N1CCN(c2nc(-c3ccccc3)ns2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20110111046A1,COC(=O)c1cc(Cl)c2[nH]c(C)nc2c1>>Cc1nc2cc(C(=O)O)cc(Cl)c2[nH]1,,CO,,[Na+].[OH-],,val
US20100152160A1,CC1(C)CN(C(=O)C2CNc3cc(Cl)ccc3O2)CCC1(O)Cc1ccc(Cl)cc1>>CC1(C)CN(CC2CNc3cc(Cl)ccc3O2)CCC1(O)Cc1ccc(Cl)cc1,,C1CCOC1,,,,val
US07368437B1,CN(C)c1nnc(Br)c(=O)[nH]1.NN>>CN(C)c1nnc(NN)c(=O)[nH]1,,O,,,,val
US20110312921A1,Cc1nn(C)c(C)c1N.O=S(=O)(Cl)c1cc(F)c(Br)cc1F>>Cc1nn(C)c(C)c1NS(=O)(=O)c1cc(F)c(Br)cc1F,,c1ccncc1,,,,val
US20140163026A1,CN(C)CCc1ccc([N+](=O)[O-])cc1>>CN(C)CCc1ccc(N)cc1,[Pd],CO,,,,val
US04666915,CCOC(=O)c1cnc(Nc2ccccc2F)[nH]c1=O>>O=C(O)c1cnc(Nc2ccccc2F)[nH]c1=O,,CC(=O)O,,O,[Na+].[OH-],val
US20120263670A1,COC(=O)c1cc(O)cc(C(=O)OC)c1>>O=C(O)c1cc(O)cc(C(=O)O)c1,,C1CCOC1,,[Li+].[OH-],,val
US04367238,CCOC(=O)C(C#N)(CC)c1cccc(Oc2ccccc2C)c1OC>>CCC(C(=O)O)c1cccc(Oc2ccccc2C)c1OC,,CC(=O)O,,Cl,,val
US06319920B1,CC(C)(C)OC(=O)N1CCC(C=O)CC1.CCN[C@@H](C)Cc1ccc2c(c1)CCO2>>CCN(CC1CCN(C(=O)OC(C)(C)C)CC1)[C@@H](C)Cc1ccc2c(c1)CCO2,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160002224A1,CC1(C)OB(c2ccc(-c3ncco3)cc2)OC1(C)C.COC(=O)c1cc(Cc2cc3cc(Br)c(Cl)cc3[nH]2)ccc1C>>Cc1ccc(Cc2cc3cc(-c4ccc(-c5ncco5)cc4)c(Cl)cc3[nH]2)cc1C(=O)O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,[Li+].[OH-],,val
US09315488B2,O=C1c2ccccc2C(=O)N1CC1(F)CCOCC1>>NCC1(F)CCOCC1,,CCO,,NN,,val
US20060223835A1,CC(C)C(C1CC(=O)C1(Cl)Cl)C(O[SiH3])(C(C)C)C(C)C>>CC(C)C(C1CC(=O)C1)C(O[SiH3])(C(C)C)C(C)C,[Zn],CC(=O)O,,CCOCC,,val
US20050165014A1,CC(=O)CC(C)=O.Nc1cccc([N+](=O)[O-])c1>>CC(=O)C=C(C)Nc1cccc([N+](=O)[O-])c1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20130126856A1,CC1(C)C2=C(C=C3N=c4ccccc4=C31)C(Br)=C1C=CC(c3ccccc3)C=C12.CC1(C)OB(c2ccc(N(c3ccccc3)c3ccc(-c4ccccc4)cc3)cc2)OC1(C)C>>CC1(C)C2=C(C=C3N=c4ccccc4=C31)C(c1ccc(N(c3ccccc3)c3ccc(-c4ccccc4)cc3)cc1)=C1C=CC(c3ccccc3)C=C12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US20150152127A1,CN(C(=O)OC(C)(C)C)C1=N[C@H]2[C@H](O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)S1>>CN(C(=O)OC(C)(C)C)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)S1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130085157A1,Cc1ccc(N=C=S)cc1Cl.NNc1nc(-c2cc(Cl)ccc2Cl)c(Br)s1>>Cc1ccc(Nc2nnc3scc(-c4cc(Cl)ccc4Cl)n23)cc1Cl,,c1ccccc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20050040364A1,C=C(C)C(=O)OCCCCCCOC(=O)c1cc(OC(=O)c2ccc(OCCCCCCOC(=O)C(=C)C)cc2)ccc1O.O=C(O)c1ccc(OC2CCCCO2)cc1>>C=C(C)C(=O)OCCCCCCOC(=O)c1cc(OC(=O)c2ccc(OCCCCCCOC(=O)C(=C)C)cc2)ccc1OC(=O)c1ccc(OC2CCCCO2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060172983A1,COC(=O)CCCCCOc1ccc(NC(=O)COCc2ccccc2)cc1>>COC(=O)CCCCCOc1ccc(NC(=O)CO)cc1,[Pd],CO,,,,val
US20040186118A1,C#CCNc1nc(Nc2ccc(N)cc2)ncc1Br.Cn1cnc(S(=O)(=O)Cl)c1>>C#CCNc1nc(Nc2ccc(NS(=O)(=O)c3cn(C)cn3)cc2)ncc1Br,,CC#N,,CCN(CC)CC,,val
US20130245000A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(-n3ccc4cc(S(C)(=O)=O)ccc43)nc2)CC1.N#CBr>>CS(=O)(=O)c1ccc2c(ccn2-c2ccc(OC3CCN(C#N)CC3)cn2)c1,,ClCCl,,CCN(CC)CC,,val
US20040171881A1,COC(=O)c1cc(I)c(O)c([N+](=O)[O-])c1>>COC(=O)c1cc(N)c(O)c(I)c1,,CCO,,Cl[Sn]Cl,,val
US20160046596A1,COCOc1cnccc1C=O>>O=Cc1ccncc1O,,C1CCOC1,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120308588A1,CC(C)(C)OC(=O)c1ccccc1B1OC(C)(C)C(C)(C)O1.CCOC(=O)[C@H](O)[C@@H](Cc1ccccc1)NC(=O)c1ccc(F)c(Br)c1>>CCOC(=O)[C@H](O)[C@@H](Cc1ccccc1)NC(=O)c1ccc(F)c(-c2ccccc2C(=O)OC(C)(C)C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20030114666A1,Cc1c(Cl)ncc(C(N)=O)c1Cl.NC1CC1.O=C(Cl)C(=O)Cl>>Cc1c(Cl)ncc(C(=O)NC(=O)NC2CC2)c1Cl,,ClCCCl,,,,val
US20080146606A1,C[C@H](O)CN.O=S(=O)(Cl)c1ccc(Br)cc1>>C[C@@H](O)CNS(=O)(=O)c1ccc(Br)cc1,,ClCCl,,CCN(CC)CC,,val
US20050250810A1,C(=NC1CCCCC1)=NC1CCCCC1.C=CC(=O)O.CNCc1c(C)c2ccccc2n1C.On1nnc2ccccc21>>Cc1c(CN(C)C(=O)/C=C/c2ccc(N)nc2)n(C)c2ccccc12,,CN(C)C=O,ClCCl,O,,val
US20060276496A1,CCOC(=O)c1[nH]c2ccc(C(=O)Nc3cccnc3)cc2c1CCCN>>O=C(Nc1cccnc1)c1ccc2[nH]c3c(c2c1)CCCNC3=O,,C1CCOC1,,C[Al](C)C,,val
US20130059830A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OCC(CCc1ccccc1)NCC(O)c1cc(-c2ccc(Cl)cc2)nn1-c1ncccn1>>CC(C)(C)OC(=O)N(CC(O)c1cc(-c2ccc(Cl)cc2)nn1-c1ncccn1)C(CO)CCc1ccccc1,,CO,,,,val
US20110028445A1,CC1(C)[C@H]2Cc3cc(O)c(NC(=O)C4CC4)cc3[C@]1(C)CCN2C(=O)C(F)(F)F>>CC1(C)[C@H]2Cc3cc4oc(C5CC5)nc4cc3[C@]1(C)CCN2C(=O)C(F)(F)F,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US04020072,C=O.CCn1nc(C)c2c(C)cc(O)nc21.CNC.Cl>>CCn1nc(C)c2c(C)c(CN(C)C)c(O)nc21.Cl,,CN(C)C=O,,,,val
US04472415,CCCCC(Br)C(=O)c1ccc(Cl)cc1.c1nc[nH]n1>>CCCCC(C(=O)c1ccc(Cl)cc1)n1cncn1,,CC#N,,,,val
US20140051679A1,CC1(C)OB(c2cccc(N3CCOCC3)c2)OC1(C)C.O=C(NC(c1ccccc1)C1CC1)c1ccc2[nH]nc(I)c2c1>>O=C(NC(c1ccccc1)C1CC1)c1ccc2[nH]nc(-c3cccc(N4CCOCC4)c3)c2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20130150339A1,CI.N#Cc1cc(Br)c(O)cc1Cl>>COc1cc(Cl)c(C#N)cc1Br,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04221915,O=C(O)C(Sc1ccccc1)c1cccs1>>O=C(O)Cc1cccs1,[Zn],CC(=O)O,,,,val
US20110230428A1,Clc1ccccc1Cl.O=C(Cl)CC[N+](=O)[O-]>>O=C(CC[N+](=O)[O-])c1ccc(Cl)c(Cl)c1,,CCCCCCC,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130085131A1,C=C[Sn](CCCC)(CCCC)CCCC.O=C1c2ccccc2C(=O)N1Cc1nc2cccc(F)c2cc1Br>>C=Cc1cc2c(F)cccc2nc1CN1C(=O)c2ccccc2C1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20110288076A1,Cc1ncc[nH]1.O=C(CCl)N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1>>Cc1nccn1CC(=O)N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1,,CCOC(C)=O,,CN(C)C=O,,val
US20140213586A1,COc1cccc(N)c1.Cc1cc(C=O)nn1C>>COc1cccc(N=Cc2cc(C)n(C)n2)c1,,CCO,,,,val
US20100081680A1,O=S(=O)(c1ccc(Cl)cc1)N1C2Cc3c(cnn3S(=O)(=O)c3ccc(Cl)cc3)C1CC(C=NO)C2.O=S(=O)(c1ccc(Cl)cc1)N1CC2=C(CC3CC(C=NO)CC2N3S(=O)(=O)c2ccc(Cl)cc2)N1>>N#CC1CC2Cc3c(cnn3S(=O)(=O)c3ccc(Cl)cc3)C(C1)N2S(=O)(=O)c1ccc(Cl)cc1.N#CC1CC2Cc3nn(S(=O)(=O)c4ccc(Cl)cc4)cc3C(C1)N2S(=O)(=O)c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US06066651,CCN(CC)CC.O=C(Cl)Cc1ccccc1.O=C(O)CC(=O)O.O=Cc1cccnc1>>O=C(O)CC(NC(=O)Cc1ccccc1)c1cccnc1,,CCO,,,,val
US20140088085A1,CCCN(CCCO[Si](C)(C)C(C)(C)C)C(=O)C1=Cc2ccc(-c3ccc(C(=O)N4CCCC4)cc3)cc2N=C(NC(=O)OC(C)(C)C)C1.CN(C)CCN>>CCCN(CCCO[Si](C)(C)C(C)(C)C)C(=O)C1=Cc2ccc(-c3ccc(C(=O)N4CCCC4)cc3)cc2N=C(NCCN(C)C)C1,,CCOC(C)=O,CN(C)C=O,,,val
US20140206663A1,CC1(OS(C)(=O)=O)CN(C(c2ccccc2)c2ccccc2)C1.CC1C(=O)NN=C2COc3cc(F)c(N)cc3N21>>CC1C(=O)NN=C2COc3cc(F)c(NC4(C)CN(C(c5ccccc5)c5ccccc5)C4)cc3N21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060211724A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=C1c2c(c(O)c3nccnc3c2O)C(=O)N1Cc1ccc2c(c1)OCO2>>Cc1ccc(S(=O)(=O)Oc2c3c(c(O)c4nccnc24)C(=O)N(Cc2ccc4c(c2)OCO4)C3=O)cc1,,ClCCl,,CCN(CC)CC,O,val
US20100035883A1,CCOC(=O)c1cccc2c1C(=O)C(c1nc3cnccc3n1C)C(c1ccc(F)cc1)N2.NN>>Cn1c(C2c3n[nH]c(=O)c4cccc(c34)NC2c2ccc(F)cc2)nc2cnccc21,,CO,,O,,val
US06894169B1,Cc1ccncc1.OCCCCCCBr>>Cc1cc[n+](CCCCCCO)cc1.[Br-],,CCO,,,,val
US20040082607A1,CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)C)c(=O)c2ccc(CCc3cscn3)cc12.Cl>>CCCCOc1c(CN)n(CC(C)C)c(=O)c2ccc(CCc3cscn3)cc12.Cl,,CCOC(C)=O,,,,val
US05698579,CCOc1cc(C(CC#N)N2C(=O)c3cccc([N+](=O)[O-])c3C2=O)ccc1OC>>CCOc1cc(C(CC#N)N2C(=O)c3cccc(N)c3C2=O)ccc1OC,[Pd],CCOC(C)=O,,[H][H],,val
US20130303515A1,CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(I)c1.OB(O)c1ccccc1>>CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccccc2)c1,,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090234130A1,C#Cc1cccc(C(=O)Cl)c1.CCCCCC.CO>>C#Cc1cccc(C(=O)OCC)c1,,CCCCCC,ClCCl,c1ccncc1,,val
US20020091261A1,COc1cc(Nc2nnc(Cc3ccncc3)c3ccccc23)ccc1Cl>>Oc1cc(Nc2nnc(Cc3ccncc3)c3ccccc23)ccc1Cl,,ClCCl,,BrB(Br)Br,,val
US20040077726A1,COC(=O)C=Cc1cccc(S(=O)(=O)Cl)c1.NCc1cccnc1>>COC(=O)C=Cc1cccc(S(=O)(=O)NCc2cccnc2)c1,,C1COCCO1,O,O=C([O-])O.[Na+],,val
US04548973,CC(=O)C1C(=O)C=C(C)OC1=O.CC1(C)CC(N)CC(C)(C)N1>>Cc1cc(=O)c(C(=O)O)c(C)n1C1CC(C)(C)NC(C)(C)C1,,O,,Cc1ccccc1,,val
US20050197396A1,CCO.C[C@H](N)C(=O)O.Cc1ccc(S(=O)(=O)O)c(C)c1>>CCOC(=O)[C@H](C)N.Cc1ccc(S(=O)(=O)O)c(C)c1,,CCO,,,,val
US20040006110A1,CC(=O)CC(=O)OC(C)C.CCCCCCCCCCCCCCCc1cccc(OCC)c1C=O.CCOC(=O)/C=C(/C)N>>CCCCCCCCCCCCCCCc1cccc(OCC)c1C1C(C(=O)OCC)=C(C)NC(C)=C1C(=O)OC(C)C,,CCCCO,,C1CCNCC1,CC(=O)O,val
US05324747,CCCCCCCCCCCCCCCCCCOc1cc(NC(=O)OC(C)(C)C)cc(S(C)=O)c1>>CCCCCCCCCCCCCCCCCCOc1cc(N)cc(S(C)=O)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140228405A1,Cl.N[C@@H]1C[C@H]1c1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1.O=CC1CC1>>Cl.O=C(Nc1ccc([C@@H]2C[C@H]2NCC2CC2)cc1)c1cccc(C(F)(F)F)c1,,C1CCOC1,CO,[BH4-].[Na+],,val
US20110071175A1,Brc1cccnc1.CC(C)(C)[Si](C)(C)OCc1ccccc1S.CN1CCCC1=O>>CC(C)(C)[Si](C)(C)OCc1ccccc1Sc1cncnc1,,O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030187023A1,CN(CCCCl)C(=O)OC(C)(C)C.Sc1ccc2cc(Cl)ccc2c1>>CN(CCCSc1ccc2cc(Cl)ccc2c1)C(=O)OC(C)(C)C,,CO,,C[O-].[Na+],,val
US06723727B1,CC(C)(C)OC(=O)NCCCCNC(=S)Nc1ccccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)NCCCCNC(=S)Nc1ccccc1N,[Pd],CO,,,,val
US20090131473A1,CCOc1cc(C(Oc2ccc(C(=N)N)cc2)C(=O)OC)ccc1OC(C)C.O=C(Cl)OCc1ccccc1>>CCOc1cc(C(Oc2ccc(C(=N)NC(=O)OCc3ccccc3)cc2)C(=O)OC)ccc1OC(C)C,,ClCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US05216020,COC(=O)c1cc2c(s1)SCC2>>O=C(O)c1cc2c(s1)SCC2,,C1CCOC1,O,[Na+].[OH-],,val
US03941785,CCCc1nc(C)c2n1N=C(N)NC2C1C(=O)NC(=O)NC1=O.Cl>>CCCc1nc(C)c2n1N=C(N)NC2C1C(=O)NC(=O)NC1=O.Cl,,CCO,CCOCC,,,val
US20150361031A1,CC(C)(C)OC(=O)N1CCN(CCO)CC1.O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O>>CC(C)(C)OC(=O)N1CCN(CCOc2ccc(Cl)cc2C(=O)Nc2ccc([N+](=O)[O-])cc2Cl)CC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100324076A1,Clc1cc(Cl)nc(-c2ccccc2)n1.O=C(NCc1ccc(Cl)cc1Cl)C1CCNCC1>>O=C(NCc1ccc(Cl)cc1Cl)C1CCN(c2cc(Cl)nc(-c3ccccc3)n2)CC1,,C1COCCO1,,[Na+].[OH-],,val
US20120010188A1,Cc1cc(C(=O)CBr)c(F)cc1Cl.Nc1cnc(Br)cn1>>Cc1cc(-c2cn3cc(Br)ncc3n2)c(F)cc1Cl,,CCO,,[Na+].[OH-],,val
US20100069404A1,CC(C)OC(=O)N[C@H]1Cc2c(n(Cc3cccnc3N3C(=O)c4ccccc4C3=O)c3ccc(C#N)cc23)C1>>CC(C)OC(=O)N[C@H]1Cc2c(n(Cc3cccnc3N)c3ccc(C#N)cc23)C1,,C1CCOC1,CCO,NN,O,val
US06469004B1,COC(=O)c1cc([N+](=O)[O-])c(N)c(F)c1Nc1ccccc1C.O=Ic1cccc(CC(=O)[O-])c1CC(=O)[O-]>>Cc1cc(I)ccc1Nc1c(C(=O)O)cc2nonc2c1F,,c1ccccc1,,,,val
US06350749B1,Cc1ccc(Cl)c(C2CC(=O)c3c(C)ccnc3C2)c1.Cl.N=C(N)NN>>Cc1ccc(Cl)c(C2CC(=NNC(=N)N)c3c(C)ccnc3C2)c1.Cl,,CCO,,Cl,O,val
US20080021053A1,CC1=C(C(=O)c2ccco2)C(c2ccc(C#N)cc2)N(CC(=O)O)C(=O)N1c1cccc(C(F)(F)F)c1.N#Cc1ccc(S(N)(=O)=O)cc1>>CC1=C(C(=O)c2ccco2)C(c2ccc(C#N)cc2)N(CC(=O)NS(=O)(=O)c2ccc(C#N)cc2)C(=O)N1c1cccc(C(F)(F)F)c1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05421971,FC(F)(F)C(F)(F)C(Cl)(Cl)C(Cl)(Cl)C(F)(F)C(F)(F)F>>FC(F)(F)C(F)(F)CCC(F)(F)C(F)(F)F,[Pd],,,[H][H],,val
US20040180927A1,CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CCN(C(=O)[C@H](CC(C)C)NC(=O)OCc2ccccc2)CC1=O.O=C(Cl)c1ccccc1>>CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CCN(C(=O)c2ccccc2)CC1=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04087524,CC(=O)OC[C@]12CC[C@H](O[Si](c3ccccc3)(c3ccccc3)c3ccccc3)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O[Si](c3ccccc3)(c3ccccc3)c3ccccc3)CC[C@@H]12>>C[C@]12CC[C@H]3[C@@H](CCC4=C[C@@H](O[Si](c5ccccc5)(c5ccccc5)c5ccccc5)CC[C@@]43CO)[C@@H]1CC[C@@H]2O[Si](c1ccccc1)(c1ccccc1)c1ccccc1,,CCOCC,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20110046132A1,CCOC(=O)c1cnn(-c2nc3c(C)c(F)ccc3n2COCCOC)c1>>Cc1c(F)ccc2[nH]c(-n3cc(C(=O)O)cn3)nc12,,CC(=O)O,,Cl,,val
US20140309227A1,NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CBr)cc2n1.OB(O)c1cncnc1>>NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(Cc3cncnc3)cc2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US04587331,C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C=O.NN>>C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C=NN,,CO,,O,,val
US20150051160A1,C=CCOC(=O)[C@H](Cc1ccc(OC(=O)NCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CSC(c2ccccc2)(c2ccccc2)c2ccccc2)C(N)=O)cc1)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OC(=O)NCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CSC(c2ccccc2)(c2ccccc2)c2ccccc2)C(N)=O)cc1)C(=O)O,,C1CCOC1,O,CCN(CC)CC,O=CO,val
US04954498,CC1(C)CC(=O)Nc2cc(N)c(N)cc21.N#Cc1ccc(C=O)cc1>>CC1(C)CC(=O)Nc2cc3nc(-c4ccc(C#N)cc4)[nH]c3cc21,,CCO,,,,val
US05268443,CCOc1ccc(C(=O)O)cc1-c1ccccc1>>O=C(O)c1ccc(O)c(-c2ccccc2)c1,,O,,CC(=O)O,,val
US20090252680A1,Nc1ccc(I)cn1.O=C(CBr)c1ccc(O)cc1>>Oc1ccc(-c2cn3cc(I)ccc3n2)cc1,,CC#N,,,,val
US20010016579A1,CCc1cc(Cl)cc2nc(S)oc12.CN1CCCNCC1>>CCc1cc(Cl)cc2nc(N3CCCN(C)CC3)oc12,,Cc1ccccc1,,,,val
US20150225404A1,O=C(OO)c1cccc(Cl)c1.c1ccc(COc2cc(-c3cncnc3)c3c(n2)CCCC3)nc1>>[O-][n+]1ccccc1COc1cc(-c2cncnc2)c2c(n1)CCCC2,,ClC(Cl)Cl,,,,val
US20110237588A1,CN(C)C=C(C(=O)c1ccc(Cl)s1)c1ccncc1.NN>>Clc1ccc(-c2n[nH]cc2-c2ccncc2)s1,,CCO,,CCN(CC)CC,O,val
US04971993,NCC(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.O=S(=O)(Cl)c1ccccc1>>O=C(OCc1ccccc1)[C@@H]1CCCN1C(=O)CNS(=O)(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US20040110742A1,CS(=O)(=O)OCCc1ccc(N2CCCC2)cc1.O[C@H]1CCNC1>>O[C@H]1CCN(CCc2ccc(N3CCCC3)cc2)C1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20150284404A1,C=CC(=O)OC.O=C1NCCc2ccccc21>>COC(=O)CCN1CCc2ccccc2C1=O,,C1CCOC1,,[Na+].[OH-],,val
US20030100764A1,C[S-].Cc1nc2cnc3ccccc3c2n1CCCCCl>>CSCCCCn1c(C)nc2cnc3ccccc3c21,,CN(C)C=O,,O,,val
US07317009B2,CCc1ccc2c(-c3cccc(C#N)c3)c(CCCCC(=O)O)c(-c3ccccc3)nn12.Nc1ccccn1>>CCc1ccc2c(-c3cccc(C#N)c3)c(CCCCC(=O)Nc3ccccn3)c(-c3ccccc3)nn12,CN(C)c1ccncc1,ClCCl,O,CCN=C=NCCCN(C)C,Cl,val
US20070270483A1,Cc1ccccc1OC(CCN(C)C)c1ccccc1.O=C(Cl)Oc1ccccc1>>Cc1ccccc1OC(CCN(C)C(=O)Oc1ccccc1)c1ccccc1,,ClCCl,,Cc1ccccc1,,val
US20120214803A1,CC(C)(C)S(=O)/N=C/c1ccc2cccnc2c1[N+](=O)[O-]>>CC(C)(C)S(=O)NCc1ccc2cccnc2c1[N+](=O)[O-],,CO,,[BH4-].[Na+],,val
US04859684,Nc1ccc(C(c2ccccc2)n2ccnc2)cc1N.S=C=S>>Sc1nc2cc(C(c3ccccc3)n3ccnc3)ccc2[nH]1,,O,,CCO,[K+].[OH-],val
US20100087427A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2N)C(C)C)ccc1OC.O=C1CCCCC1>>COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2NC2CCCCC2)C(C)C)ccc1OC,,ClCCCl,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040259912A1,CCC(=O)c1cc(N)ccc1OCc1ccc(C(C)(C)C)cc1.COc1ccc(N=C=O)cc1>>CCC(=O)c1cc(NC(=O)Nc2ccc(OC)cc2)ccc1OCc1ccc(C(C)(C)C)cc1,,C1CCOC1,,,,val
US20140309208A1,O=C(O)c1cccc([N+](=O)[O-])c1O.O[C@@H]1CCNC1>>O=C(c1cccc([N+](=O)[O-])c1O)N1CC[C@@H](O)C1,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US04371537,O=[N+]([O-])c1ccc(Oc2ccc(Cl)c(Cl)c2)nc1>>Nc1ccc(Oc2ccc(Cl)c(Cl)c2)nc1,[Pd],CCO,,,,val
US20150344481A1,Fc1ccc(-c2cn3c(n2)COCC3)cc1.O=C1CCC(=O)N1Br>>Fc1ccc(-c2nc3n(c2Br)CCOC3)cc1,,ClCCl,,,,val
US20090264650A1,CCI.O=C1C(Cc2ccccc2O)CCN1C1CCCCC1>>CCOc1ccccc1CC1CCN(C2CCCCC2)C1=O,,O,,CN(C)C=O,[H-].[Na+],val
US20080176883A1,CC(C)(C)OC(=O)NC1CCNC1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)NC1CCN(C(=O)n2ccnc2)C1,,C1CCOC1,ClCCl,,,val
US20020183320A1,Nc1nc[nH]n1.O=Cc1ccc(Cl)cc1Cl.[C-]#[N+]C(C)(C)C>>CC(C)(C)Nc1c(-c2ccc(Cl)cc2Cl)nc2nc[nH]n12,,[O-][Cl+3]([O-])([O-])O,,,,val
US20090274655A1,COC(=O)c1sc(-c2ccc(N)cc2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C(C)C.O=C(O)c1cccnn1>>COC(=O)c1sc(-c2ccc(NC(=O)c3cccnn3)cc2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070072954A1,CCC1(CC)COC2(OC1)OCC1(CC=CCC1)CO2.O=C(OO)c1cccc(Cl)c1>>CCC1(CC)COC2(OC1)OCC1(CCC3OC3C1)CO2,,ClCCl,,O=C([O-])O.[Na+],,val
US20010056186A1,O=C(O)c1cccnc1C(O)=NCc1ccccc1>>O=C(O)C1CCCNC1C(O)=NCc1ccccc1,[Pd],Cc1ccccc1,,,,val
US06380239B1,NC(=O)CC(C(=O)O)N1C(=O)c2cccc([N+](=O)[O-])c2C1=O>>NC(=O)CC(C(=O)O)N1C(=O)c2cccc(N)c2C1=O,[Pd],CN(C)C=O,,[H][H],,val
US20160031847A1,Cc1csc(C(=O)OC(C)(C)C)c1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)c1cc(CBr)cs1,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,,,val
US20090239865A1,COc1ccc(C(C)C)cc1B(O)O.Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2ccccc2Br)n1>>COc1ccc(C(C)C)cc1-c1ccccc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCO,O=C([O-])[O-].[Na+].[Na+],,val
US20090163586A1,NS(=O)(=O)c1ccccc1NS(=O)(=O)c1cccc(Br)c1.OB(O)c1cc(Cl)ccc1Cl>>NS(=O)(=O)c1ccccc1NS(=O)(=O)c1cccc(-c2cc(Cl)ccc2Cl)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20110257179A1,COc1ccc(Cn2cc(-c3nc(Nc4cccc(I)n4)sc3C)cn2)cc1>>Cc1sc(Nc2cccc(I)n2)nc1-c1cn[nH]c1,,O=C(O)C(F)(F)F,,O=C([O-])[O-].[Na+].[Na+],,val
US20100273764A1,Cc1nc(-c2nc3ccccc3nc2Nc2cccc3[nH]ncc23)cc(S(C)=O)n1.N>>Cc1nc(N)cc(-c2nc3ccccc3nc2Nc2cccc3[nH]ncc23)n1,,C1COCCO1,,,,val
US04952573,O=C(O)c1ccnc2ccccc12>>O=C(O)C1CCNC2CCCCC21,[Rh],CC(=O)O,,,,val
US20120202856A1,CC(C)(C)C(=O)O.COC(=O)C(Cl)C(C)=O>>COC(=O)C(OC(=O)C(C)(C)C)C(C)=O,,CCOC(C)=O,,,,val
US04757068,CC(C)(C)OC(=O)CI.CCOC(CC(=C=O)c1ccccc1)NC1(C)C(=O)N(CC(=O)OC(C)(C)C)c2ccccc21>>CC1(NC(CCc2ccccc2)C(=O)O)C(=O)N(CC(=O)O)c2ccccc21,,CCCCCC,,CCOCC,,val
US04699905,CC(C)(C)OC(=O)NCC(O)c1ccsc1.ClP(Cl)(Cl)(Cl)Cl>>CC(C)(C)OC(=O)NCC(Cl)c1ccsc1,,ClCCl,,[Na+].[OH-],,val
US20110305661A1,Cl.O=C(Cl)CCCl.O=[N+]([O-])c1ccccc1.O=[N+]([O-])c1ccccc1S(=O)(=O)NCCn1c2ccccc2c2ccccc21>>O=C(CCCl)c1ccc2c(c1)c1cc(C(=O)CCCl)ccc1n2CCNS(=O)(=O)c1ccccc1[N+](=O)[O-],,O=[N+]([O-])c1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20020022575A1,Cc1cc(C)c(C(C(=O)O)C(=O)O)c(Cl)c1.O=S(Cl)Cl>>Cc1cc(C)c(C(=C=O)C(=O)Cl)c(Cl)c1,,Cc1ccccc1,,,,val
US05268375,Cc1ccc(I)cc1.O=[N+]([O-])c1ccccc1Br>>Cc1ccc(-c2ccccc2[N+](=O)[O-])cc1,,ClCCl,,,,val
US04880781,CC(C)C[C@H](O)[C@@H](O)C[C@H](C(=O)O)C(C)C.O=C1CCC(=O)N1Br>>CC(C)C[C@@H](Br)[C@@H](O)C[C@H](C(=O)O)C(C)C,,CCOCC,c1ccccc1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090170913A1,CN(C)C1CCN(c2nc3ccc(N)cc3s2)C1.O=C(O)c1cc(-c2ccccc2)on1>>CN(C)C1CCN(c2nc3ccc(NC(=O)c4cc(-c5ccccc5)on4)cc3s2)C1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US03975535,CC(=O)c1cccc(C)c1C(=O)O.CCO>>Cc1c(C(=O)O)oc(=O)c2c(C)cccc12,,CCO,,,,val
US20050070562A1,Cc1c(Cl)ncnc1SC1CCN(C(=O)OC(C)(C)C)CC1>>Cc1c(Cl)ncnc1SC1CCNCC1,,C1COCCO1,,Cl,,val
US20090197871A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1c(Br)cccc1CN>>COc1c(Br)cccc1CNC(=O)OC(C)(C)C,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US20040132752A1,CC(=O)Nc1ccc(-n2ccn(-c3ccc(Oc4ccccc4)cc3)c2=O)cc1>>Nc1ccc(-n2ccn(-c3ccc(Oc4ccccc4)cc3)c2=O)cc1,,CCO,,Cl,N,val
US20020099212A1,COC(=O)c1ccc2nc(C)n(Cc3ccc(N)cc3Cl)c2n1.O=S(=O)(Cl)c1ccccc1>>COC(=O)c1ccc2nc(C)n(Cc3ccc(NS(=O)(=O)c4ccccc4)cc3Cl)c2n1,,ClCCl,,O,c1ccncc1,val
US20150344468A1,C=CCCC(O)c1ccc(F)nc1.O=C(OO)c1cccc(Cl)c1>>OCC1CCC(c2ccc(F)nc2)O1,,ClCCl,,,,val
US20140221348A1,BrCCSc1cccs1.COc1ccc2ncc(SCCN3CCC(N)CC3)nc2c1>>COc1ccc2ncc(SCCN3CCC(NCCSc4cccs4)CC3)nc2c1,,CC#N,,,,val
US20080249093A1,Cc1cc(C=CC(=O)OC(C)(C)C)ccc1-c1nsc(-c2ccc(OC(C)C)c(C#N)c2)n1>>Cc1cc(CCC(=O)OC(C)(C)C)ccc1-c1nsc(-c2ccc(OC(C)C)c(C#N)c2)n1,[Pd],CCOC(C)=O,CO,[H][H],,val
US05932599,CC(C)N.CNc1nc(Cl)cc(NS(=O)(=O)c2ccc(N)cc2)n1>>CNc1nc(NC(C)C)cc(NS(=O)(=O)c2ccc(N)cc2)n1,,CCO,,,,val
US20110160243A1,CC(C)Oc1ccc(CCl)cc1C(F)(F)F.CCOC(=O)CC1CCCn2c1cc1cc(O)ccc12>>CCOC(=O)CC1CCCn2c1cc1cc(OCc3ccc(OC(C)C)c(C(F)(F)F)c3)ccc12,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150126530A1,Nc1ccc(F)cc1F.O=C(O)c1c(Oc2ccc(F)cc2)nc2ncccn12>>O=C(Nc1ccc(F)cc1F)c1c(Oc2ccc(F)cc2)nc2ncccn12,,ClCCl,,On1nnc2ccccc21,,val
US20110118311A1,CCC1(C(=O)[O-])CCN(C(=O)OC(C)(C)C)CC1.NN>>CC(C)(C)OC(=O)N1CCC(C(=O)NN)CC1,,CCO,,O,,val
US20040259926A1,CI.COc1cc2c(Oc3ccc(C4CCCCC4)cc3)c(C(=O)Nc3nn[nH]n3)sc2cc1C>>COc1cc2c(Oc3ccc(C4CCCCC4)cc3)c(C(=O)Nc3nnn(C)n3)sc2cc1C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070155721A1,CCOC(=O)c1cc2c(O)cccc2[nH]1.O=[N+]([O-])c1c(F)cc(F)cc1F>>CCOC(=O)c1cc2c(Oc3cc(F)cc(F)c3[N+](=O)[O-])cccc2[nH]1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090041722A1,CC1(C)Cc2ccc(C#N)cc2C1=O>>CC1(C)Cc2ccc(C#N)cc2C1O,,CCO,,Cl,[BH4-].[Na+],val
US20070185133A1,CC(C)(C)OC(=O)NCCn1c(=O)[nH]c2ccccc21>>NCCn1c(=O)[nH]c2ccccc21,,CCOCC,,Cl,,val
US20080146812A1,CC(C)(C)OC(=O)N1CC2CNCC(C1)O2.CN(C)C(=O)N(CC=O)CCCc1ccc(C#N)cc1>>CN(C)C(=O)N(CCCc1ccc(C#N)cc1)CCN1CC2CN(C(=O)OC(C)(C)C)CC(C1)O2,,ClCCl,,CC(=O)O,[BH3-]C#N.[Na+],val
US06936602B1,CC=CCN1CCC(C(=O)OC)=Cc2cc(-c3ccc(OCCOCCCC)cc3)ccc21>>CC=CCN1CCC(C(=O)O)=Cc2cc(-c3ccc(OCCOCCCC)cc3)ccc21,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US04536209,CCOC(=O)C(C)Oc1cc(N)ccc1Br.O=C1OC(=O)C2CCCCC12>>CCOC(=O)C(C)Oc1cc(N2C(=O)C3=C(CCCC3)C2=O)ccc1Br,,O,,CC(=O)O,,val
US20140011802A1,O=C(NC1=N[C@@]2(c3ccc(F)cc3F)CO[C@H](CF)[C@H]2CS1)c1ccccc1>>NC1=N[C@@]2(c3ccc(F)cc3F)CO[C@H](CF)[C@H]2CS1,,CO,,C1CCC2=NCCCN2CC1,,val
US20140323501A1,CC(N)=O.CCOC(=O)C(CC(=O)c1ccc(Sc2ccc(C(=O)COC(=O)CC)cc2)cc1)(NC(C)=O)C(=O)OCC>>CCOC(=O)C(CC(=O)c1ccc(Sc2ccc(-c3coc(CC)n3)cc2)cc1)(NC(C)=O)C(=O)OCC,,Cc1ccccc1C,,CCOCC,FB(F)F,val
US20140288123A1,Cc1cc(C)c(CNC(=O)c2ccc(Oc3cccc(Br)c3C#N)c(Cl)c2)c(O)n1.OB(O)c1ccncc1>>Cc1cc(C)c(CNC(=O)c2ccc(Oc3cccc(-c4ccncc4)c3C#N)c(Cl)c2)c(O)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US04101659,CI.NC(=S)NC(c1ccccc1)c1ccc(Cl)cc1>>CSC(=N)NC(c1ccccc1)c1ccc(Cl)cc1.I,,CO,,,,val
US20110306607A1,CC(C)(C)OC(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2.NO>>CC(C)(C)OC(=O)N1CCC2(CC1)C/C(=N\O)c1ccccc1O2,,CCOC(C)=O,CO,O,,val
US20060241296A1,O=C1CCC(=O)N1Br.OC1CCc2cccc(Nc3cc(-c4ccc(C(F)(F)F)cc4)ncn3)c2C1>>OC1CCc2c(Br)ccc(Nc3cc(-c4ccc(C(F)(F)F)cc4)ncn3)c2C1,,CN(C)C=O,,,,val
US20080312226A1,CC(C)(C)OC(=O)N1CCC(c2nc(-c3ccccc3F)cs2)CC1>>Fc1ccccc1-c1csc(C2CCNCC2)n1,,CCOC(C)=O,,Cl,,val
US20050165065A1,CN(C(=O)CCCCC(c1ccc(F)cc1)c1ccc(F)cc1)[C@@H]1CCNC1.COc1c(C(C)(C)C)cc(C(=O)O)cc1C(C)(C)C>>COc1c(C(C)(C)C)cc(C(=O)N2CC[C@@H](N(C)C(=O)CCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1C(C)(C)C,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US04219660,CC(=CCO)C[N+](=O)[O-].O=C(Cl)c1ccc(Cl)cc1Cl>>CC(=CCOC(=O)c1ccc(Cl)cc1Cl)C[N+](=O)[O-],,c1ccccc1,,,,val
US20110257100A1,CCCCOC(=O)N1CCC(N(Cc2ccc(-c3cc4nccc(Oc5ccc(NC(=O)NC6CC6)cc5F)c4s3)nc2)C(C)=O)CC1>>CC(=O)N(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1)C1CCNCC1,,CCOC(C)=O,,Cl,,val
US20130158001A1,CC(C)(C)OC(=O)C1CN(Cc2ccc(-c3noc(CCC4(c5cccc(C(F)(F)F)c5)CCOCC4)n3)cc2)C1>>O=C(O)C1CN(Cc2ccc(-c3noc(CCC4(c5cccc(C(F)(F)F)c5)CCOCC4)n3)cc2)C1,,O=C(O)C(F)(F)F,,,,val
US20070142434A1,CN.O=C(O)C1CCN(CCCOc2ccc(-n3nc4ccccc4c3Cl)cc2)CC1>>CNC(=O)C1CCN(CCCOc2ccc(-n3nc4ccccc4c3Cl)cc2)CC1,,ClCCl,,Cl,O=C(Cl)C(=O)Cl,val
US20030069297A1,Cc1c(C(=O)N2CCOCC2)c[nH]c1C=O.O=C(O)Cc1cccc(-c2cccc3c2CC(=O)N3)c1>>Cc1c(C(=O)N2CCOCC2)c[nH]c1/C=C1\C(=O)Nc2cccc(-c3cccc(CC(=O)O)c3)c21,,CCO,,,,val
US20160009744A1,CC1(C)O[C@H]2[C@H](Nc3ncncc3C(=O)c3cc(Cc4cccc(Br)c4)cs3)C[C@H](CO)[C@H]2O1.NS(=O)(=O)Cl>>CC1(C)O[C@H]2[C@H](Nc3ncncc3C(=O)c3cc(Cc4cccc(Br)c4)cs3)C[C@H](COS(N)(=O)=O)[C@H]2O1,,CN(C)C=O,,CCN(CC)CC,,val
US05712300,CC(C)CC1(C(CCN)C(=O)OC(C)(C)C)CCN(CCc2ccccc2)C1=O.Cc1ccccc1S(=O)(=O)Cl>>Cc1ccc(S(=O)(=O)NCCC(C(=O)OC(C)(C)C)C2(CC(C)C)CCN(CCc3ccccc3)C2=O)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100120798A1,Cc1ccc(NC(=O)C2(CN=C(c3ccccc3)c3ccccc3)CCNCC2)nc1.Clc1ncnc2[nH]ccc12>>Cc1ccc(NC(=O)C2(CN=C(c3ccccc3)c3ccccc3)CCN(c3ncnc4[nH]ccc34)CC2)nc1,,CCCCO,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20020183319A1,CN1C(=O)Cc2c(Nc3ccc(F)c(Cl)c3)ncnc21.Cc1[nH]c(C=O)c(C)c1CCCN1CCOCC1>>Cc1[nH]c(C=C2C(=O)N(C)c3ncnc(Nc4ccc(F)c(Cl)c4)c32)c(C)c1CCCN1CCOCC1,C1CCNCC1,CCO,,,,val
US20090105271A1,Nc1ccc(S(=O)(=O)Nc2nccs2)cn1.O=C1OCC[C@@H]1N1CCc2c1ccc(F)c2Cl>>O=C(Nc1ccc(S(=O)(=O)Nc2nccs2)cn1)[C@H](CCO)N1CCc2c1ccc(F)c2Cl,,ClCCCl,,C[Al](C)C,Cl,val
US20090111730A1,COC(=O)CCCCCCCCCCCCCCCBr.N#CCC#N>>COC(=O)CCCCCCCCCCCCCCCC(C#N)C#N,,CC#N,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20090324581A1,Cc1c(OCc2ccc(C3CCCC3)c(C(F)(F)F)c2)ccc2c1CCN2C(=O)CN(CCC(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>Cc1c(OCc2ccc(C3CCCC3)c(C(F)(F)F)c2)ccc2c1CCN2C(=O)CNCCC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100249094A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)c(OC)cc3C)c(F)c12.Cc1cnc(C2(N)CC2)nc1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5ncc(C)cn5)CC4)c(OC)cc3C)c(F)c12,,CN(C)C=O,,CCN(CC)CC,,val
US20070072813A1,C#C[Si](C)(C)C.CC(=O)OC[C@H]1O[C@](O)(Oc2nn(C(C)C)c(C)c2Cc2ccc(I)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@](O)(Oc2nn(C(C)C)c(C)c2Cc2ccc(C#C[Si](C)(C)C)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,CCN(CC)CC,CCOC(C)=O,val
US20140288081A1,C=CCC1(OC(C)=O)CCN(C(=O)OC(C)(C)C)CC1.CC1(C)OI(C(F)(F)F)c2ccccc21>>CC(=O)OC1(/C=C/CC(F)(F)F)CCN(C(=O)OC(C)(C)C)CC1,[Cu]I,CO,,,,val
US05041582,CCCCCCCC(C(=O)OCC)C(=O)[c-]1cccc1.[Fe+2].c1cc[cH-]c1>>CCCCCCCC(C(=O)O)C(=O)[c-]1cccc1.[Fe+2].c1cc[cH-]c1,,CCO,,[K+].[OH-],,val
US20030055071A1,CS(=O)(=O)Cl.O=S1(=O)CCNCCN1>>CS(=O)(=O)N1CCNS(=O)(=O)CC1,,ClCCl,,CCN(CC)CC,,val
US20080027049A1,CCCCCC(=O)Cl.Nc1ccc2oc3c(c2c1)CCCCCC3>>CCCCCC(=O)Nc1ccc2oc3c(c2c1)CCCCCC3,,CC(Cl)Cl,,,,val
US20030087882A1,C=C(C)c1cc(Br)c2ccccc2n1.COC(=O)c1ccc(C=O)cc1>>C=C(C)c1cc(C(O)c2ccc(C(=O)OC)cc2)c2ccccc2n1,,C1CCOC1,,[Li]CCCC,,val
US20150353505A1,COC(=O)c1cc[nH]n1.O=S(=O)(OCC(F)F)C(F)(F)F>>COC(=O)c1ccnn1CC(F)F,,CC#N,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100168122A1,C=CCn1c(Cl)nc2c1c(=O)n(CCCO)c(=O)n2CCCC(F)(F)F.CS(=O)(=O)OS(C)(=O)=O>>C=CCn1c(Cl)nc2c1c(=O)n(CCCOS(C)(=O)=O)c(=O)n2CCCC(F)(F)F,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US04672118,CCCCCCCCCCCCc1ccc(N)cc1.O=S(=O)([O-])C(F)(F)F.c1ccc(-c2cc(-c3ccccc3)[o+]c(-c3ccccc3)c2)cc1>>CCCCCCCCCCCCc1ccc(-[n+]2c(-c3ccccc3)cc(-c3ccccc3)cc2-c2ccccc2)cc1.O=S(=O)([O-])C(F)(F)F,,CCO,,,,val
US20080027049A1,CC(C)(C)N=C=O.Nc1ccc2oc3c(c2c1)CCCC3>>CC(C)(C)NC(=O)Nc1ccc2oc3c(c2c1)CCCC3,,C1CCOC1,,c1ccncc1,,val
US20140350058A1,Cn1oc(=O)nc1/C(=N\OCc1cccc(NC(=O)OC(C)(C)C)n1)c1ccccc1>>Cn1oc(=O)nc1/C(=N\OCc1cccc(N)n1)c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090082403A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ncccc1-c1cc(Cc2ccc(COc3ccccn3)cc2)no1>>Nc1ncccc1-c1cc(Cc2ccc(COc3ccccn3)cc2)no1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20120114739A1,COC(=O)Cc1ccc(Oc2cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3nccc3n2)cc1.O=C1CCC(=O)N1I>>COC(=O)Cc1ccc(Oc2cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3ncc(I)c3n2)cc1,,CC#N,,,,val
US05593993,CCOC(=O)CCl.c1ccc2[nH]nnc2c1>>CCOC(=O)Cn1nc2ccccc2n1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20100234367A1,O=C1c2ccccc2C(=O)N1[C@H]1CCC[C@@H](c2cccnc2)C1>>N[C@H]1CCC[C@@H](c2cccnc2)C1,,CCO,,,,val
US20130109679A1,CCOC(=O)c1ccc2cc(C(=O)OCC)n(C(C)C#N)c2c1>>CCOC(=O)c1ccc2cc3n(c2c1)C(C)CNC3=O,O=[Pt],CCO,,,,val
US20140275591A1,CCCCCCCCCCC/C=C/C(=O)O.O=C(Cl)C(=O)Cl>>CCCCCCCCCCC/C=C/C(=O)Cl,,ClCCl,,,,val
US20130072467A1,O=C1N=C(NC2CCCCC2)CS1.O=CC1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1>>O=C1N=C(NC2CCCCC2)/C(=C/C2CCN(Cc3ccc(C(F)(F)F)cc3C(F)(F)F)CC2)S1,,CC(C)O,,C1CC[NH2+]CC1.CC(=O)[O-],,val
US20060173019A1,O=[N+]([O-])c1cc(Cl)cnc1Br.Oc1ccccc1F>>O=[N+]([O-])c1cc(Cl)cnc1Oc1ccc(F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120190677A1,CC(C)(C)c1ccc(-c2cccc(C3CC(C)(C)c4cc(C(=O)O)ccc4N3)c2)cc1.CS(N)(=O)=O>>CC(C)(C)c1ccc(-c2cccc(C3CC(C)(C)c4cc(C(=O)NS(C)(=O)=O)ccc4N3)c2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20150250785A1,CCOC(=O)/C(O)=C1\CN(C(=O)OC(C)(C)C)CCC1=O.NN>>CCOC(=O)c1n[nH]c2c1CN(C(=O)OC(C)(C)C)CC2,,CC(=O)O,,O,,val
US20100069383A1,CCOc1ccc(N)c(F)c1.CCOc1ccc(Nc2nc(CCl)nc3ccccc23)c(F)c1.ClCc1nc(Cl)c2ccccc2n1>>CCOc1ccc(N(C)c2nc(CN)nc3ccccc23)c(F)c1,Cl,CC(C)O,,,,val
US20090005560A1,CN(C)C(OC(C)(C)C)N(C)C.COC(=O)CNC(=O)OCc1ccccc1.Cc1ccccc1>>O=C(Nc1cnc(-c2ccccc2)[nH]c1=O)OCc1ccccc1,,Cc1ccccc1,,,,val
US20030207877A1,CN1C(=O)Cn2cc(C(=O)NCc3ccc(Cl)cc3)c(=O)c3cc(CCl)cc1c32.CNCC(O)Cc1ccccc1>>CN(Cc1cc2c3c(c1)c(=O)c(C(=O)NCc1ccc(Cl)cc1)cn3CC(=O)N2C)CC(O)Cc1ccccc1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US05843983,CCOC(=O)N1C[C@H](O)C[C@H]1CCOc1ccc(C)cc1CCc1ccccc1>>Cc1ccc(OCC[C@@H]2C[C@@H](O)CN2C)c(CCc2ccccc2)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030158178A1,CCCCCC(CO)c1ccc2c(c1)N(C)CCC2(C)C.COC(=O)c1ccc(O)cc1>>CCCCCC(COc1ccc(C(=O)OC)cc1)c1ccc2c(c1)N(C)CCC2(C)C,,C1CCOC1,CCOC(C)=O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070099929A1,C=C(C)OC.CCOC(=O)c1cc(-c2ccccc2)sc1N>>CCOC(=O)c1cc(-c2ccccc2)sc1NC(C)C,,ClCCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US20080020986A1,COC(=O)C1C(O[Si](C)(C)C(C)(C)C)CCN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCC(O[Si](C)(C)C(C)(C)C)C1CO,,C1CCOC1,CO,[BH4-].[Li+],,val
US20130252936A1,CC(=O)OC(C)=O.Cn1nc(-c2ccccc2Cl)cc1N>>CC(=O)Nc1cc(-c2ccccc2Cl)nn1C,,c1ccncc1,,,,val
US06486156B1,COC(=O)c1ccc(/C=C/Cc2cncn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1-c1ccc(F)cc1>>COC(=O)c1ccc(/C=C/Cc2cnc[nH]2)cc1-c1ccc(F)cc1,,CO,,CC(=O)O,Cl,val
US20150080364A1,Fc1cc(N2CCOCC2)ccc1CN1CCNCC1.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O>>O=C(ON1C(=O)CCC1=O)N1CCN(Cc2ccc(N3CCOCC3)cc2F)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05922899,CC(N)c1ccc2ccccc2c1.COCC(=O)OC>>COCC(=O)N[C@H](C)c1ccc2ccccc2c1,,COC(C)(C)C,,,,val
US20090149425A1,CCOC(=O)c1cnn(C(C)(C)C)c1N.COC1CCC(OC)O1>>CCOC(=O)c1cnn(C(C)(C)C)c1-n1cccc1,,CC(=O)O,,,,val
US20060167107A1,CCCCCCCCCCCCCCCc1cccc(OC)c1C(=O)Cl.N#Cc1ccc(N)cc1C(F)(F)F>>CCCCCCCCCCCCCCCc1cccc(OC)c1C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,,val
US20130129753A1,C=O.C[C@]1(C(=O)O)CCCN1>>CN1CCC[C@]1(C)C(=O)O,[Pd],CO,O,[H][H],,val
US05872118,CC(C)(C)[Si](C)(C)OC1C/C(=C\C(N)=O)c2cc(F)ccc21>>NC(=O)/C=C1\CC(O)c2ccc(F)cc21,,CCO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20050107428A1,CC(C)(C)OC(=O)N1CCC(O)CC1.N#Cc1ccc(F)cc1Cl>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(C#N)c(Cl)c2)CC1,,COCCOC,,CC(C)(C)[O-].[K+],,val
US20110201593A1,CC(=O)Cl.O=[N+]([O-])c1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1N[C@H]1CCC[C@H](O)C1>>CC(=O)OC1CCCC(Nc2c([N+](=O)[O-])cnc3c2ccn3S(=O)(=O)c2ccccc2)C1,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20050261347A1,Cc1ccc(S(=O)(=O)OCC2Cc3c(cccc3-c3ccccc3)O2)cc1.OB(O)c1cccc(C(F)(F)F)c1>>Cc1ccc(S(=O)(=O)OCC2Cc3cccc(-c4cccc(C(F)(F)F)c4)c3O2)cc1,Cc1ccccc1[P](c1ccccc1C)(c1ccccc1C)[Pd](Cl)(Cl)[P](c1ccccc1C)(c1ccccc1C)c1ccccc1C,,,O=C([O-])[O-].[K+].[K+],,val
US05166347,COC(=NC#N)c1ccccn1.NCCc1ccc(Cl)cc1>>N#CNC(=NCCc1ccc(Cl)cc1)c1ccccn1,,CO,,,,val
US20080125436A1,CC(Oc1nnc(-c2ccnc(OCc3ccccc3)c2)n1C)c1cc(-c2cccc(Cl)c2)on1>>CC(Oc1nnc(-c2cc[nH]c(=O)c2)n1C)c1cc(-c2cccc(Cl)c2)on1,[Pd],CCO,ClCCl,,,val
US20140200257A1,CC1(C)OC[C@H](CCCOCc2ccccc2)O1>>OC[C@@H](O)CCCOCc1ccccc1,Cl,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20040147612A1,CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(N)cc1.O=Cc1ccccc1>>CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(NCc2ccccc2)cc1,CC(=O)O,CO,O,[BH4-].[Na+],,val
US04379788,COc1cccc2c(=O)[nH]c(-c3ccc(O)cc3)nc12.ClCCCBr>>COc1cccc2c(=O)[nH]c(-c3ccc(OCCCCl)cc3)nc12,,O=S1(=O)CCCC1,,O=C([O-])[O-].[K+].[K+],,val
US20090143353A1,Cc1c(C2=CC(O)CC2)c(N2CC[C@H](N(C)C)C2)c2oc(C3CC3)nc2c1C#N>>Cc1c(C2C=CC=C2)c(N2CC[C@H](N(C)C)C2)c2oc(C3CC3)nc2c1C#N,,CCO,CCOCC,Cl,,val
US20100179126A1,CI.COc1ccc(C(=O)O)c([N+](=O)[O-])c1>>COC(=O)c1ccc(OC)cc1[N+](=O)[O-],,CN(C)C=O,,C1CCC2=NCCCN2CC1,O,val
US20030119819A1,CNC.O=C(O)CCc1c[nH]c2c1C(=O)CCC2>>CN(C)C(=O)CCc1c[nH]c2c1C(=O)CCC2,,C1CCOC1,ClCCl,O=C(n1ccnc1)n1ccnc1,,val
US20050090533A1,CN(C(=O)C(C)(C)c1cc(Cl)cc(Cl)c1)c1cnc(Cl)cc1-c1ccccc1Cl.OC[C@@H]1CCCN1>>CN(C(=O)C(C)(C)c1cc(Cl)cc(Cl)c1)c1cnc(N2CCC[C@H]2CO)cc1-c1ccccc1Cl,,O=C([O-])O,[Na+],CS(C)=O,,val
US20060128690A1,CN1CCCC1c1ccc(CCNC(=O)c2ccc(Br)cc2)cc1>>CN1CCCC1c1ccc(CCN)cc1,,Cl,,O,,val
US20110105533A1,CC1(C)C2CC[C@@]1(CS(=O)(=O)O)C(=O)C2.N[C@@H]1COC[C@@H]1Oc1ccc(Br)cc1>>CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.N[C@H]1COC[C@H]1Oc1ccc(Br)cc1,,CC(C)O,,O,,val
US06426345B1,COC(=O)Cc1cccc(-n2c(=O)c(Cc3ccccc3)nc3cccnc32)c1>>O=C(O)Cc1cccc(-n2c(=O)c(Cc3ccccc3)nc3cccnc32)c1,,C1COCCO1,CO,Cl,[Na+].[OH-],val
US20050277676A1,CCCCc1csc(-c2ccccc2NC(=O)OCC2CCN(C(=O)OC(C)(C)C)CC2)n1.Cl>>CCCCc1csc(-c2ccccc2NC(=O)OCC2CCNCC2)n1.Cl,,CCOC(C)=O,,,,val
US07157487B2,COC(=O)c1ccc(OC[C@@H]2C[C@H](Oc3ccccc3)CN2C(=O)OC(C)(C)C)cc1>>COC(=O)c1ccc(OC[C@@H]2C[C@H](Oc3ccccc3)CN2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060229324A1,CC1=NN(c2ccccc2)C(=O)C1.CN(C)C=O.O=P(Cl)(Cl)Cl>>Cc1nn(-c2ccccc2)c(Cl)c1C=O,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20060128707A1,CC(=O)N[C@@H](C(=O)O)C1=CCC=CC1>>CC(=O)N[C@@H](C(=O)O)C1CCCCC1,O=[Pt],CO,,,,val
US20120238600A1,CC(C)(C)OC(=O)N1C2C=C(OS(=O)(=O)C(F)(F)F)CC1CC2.C[Sn](C)(C)[Sn](C)(C)C>>CC(C)(C)OC(=O)N1C2C=C([Sn](C)(C)C)CC1CC2,,C1CCOC1,,[Cl-].[Li+],,val
US20130102776A1,CC(=O)c1cc2c(c(C=O)c1O)OCO2.CC(C)(C)OC(=O)N1CCNCC1>>CC(=O)c1cc2c(c(CN3CCN(C(=O)OC(C)(C)C)CC3)c1O)OCO2,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20050197331A1,Nc1cc([N+](=O)[O-])ccc1O.O=C(O)c1ccccc1>>O=[N+]([O-])c1ccc2oc(-c3ccccc3)nc2c1,,CO,ClC(Cl)Cl,[Br-].[K+],,val
US08569495B2,CCOC(=O)C1CCN(c2ccc(C(C)(C)C)cc2)CC1>>CC(C)(C)c1ccc(N2CCC(C(=O)O)CC2)cc1,,CO,,[Na+].[OH-],,val
US20020111374A1,COc1ccc(C(=O)Cl)cc1.COc1ccc(CC(=O)c2ccc(OC)cc2)cc1>>COc1ccc(C(=O)C(C(=O)c2ccc(OC)cc2)c2ccc(OC)cc2)cc1,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US20070032515A1,Cc1n[nH]c(N)c1-c1cc(F)c2c(c1)OCCO2.O=Cc1cc(Cl)c(O)cc1F>>Cc1n[nH]c2nc(-c3cc(Cl)c(O)cc3F)c3c(F)c4c(cc3c12)OCCO4,,O=C(O)C(F)(F)F,,,,val
US20080051418A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.OCc1cc(CO)cc(Oc2ncc(C(F)(F)F)cc2Cl)c1>>CC(C)(C)[Si](OCc1cc(CO)cc(Oc2ncc(C(F)(F)F)cc2Cl)c1)(c1ccccc1)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20060106089A1,COc1ccc(S(=O)(=O)C(F)(F)F)cc1S(=O)(=O)Nc1ccccc1N.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1>>COc1ccc(S(=O)(=O)C(F)(F)F)cc1S(=O)(=O)Nc1ccccc1NS(=O)(=O)c1cccc([N+](=O)[O-])c1,,ClCCl,c1ccncc1,,,val
US20150111857A1,CC(C)(C)OC(=O)N1CCO[C@H](Cn2cc(Nc3ncnc(Cl)n3)cn2)C1.O=C(c1ccccc1)c1cnc(N2CCNCC2)nc1>>CC(C)(C)OC(=O)N1CCO[C@H](Cn2cc(Nc3ncnc(N4CCN(c5ncc(C(=O)c6ccccc6)cn5)CC4)n3)cn2)C1,,C1COCCO1,,CCN(C(C)C)C(C)C,Cl,val
US06403791B1,CCI.N#Cc1nc[nH]c1N>>CCn1cnc(C#N)c1N,,C1CCOC1,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20160272617A1,CC(C)(C)OC(=O)CCc1nnc(-c2ccc(N)cc2)[nH]1.Cc1cc(C(=O)NC(C)C)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)O)cc1>>Cc1cc(C(=O)NC(C)C)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nnc(CCC(=O)OC(C)(C)C)[nH]3)cc2)cc1,,CCOC(C)=O,CS(C)=O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US05530022,CC(=O)CC1C(C(=O)O)C1(C)C.COS(=O)(=O)OC>>COC(=O)C1C(CC(C)=O)C1(C)C,,CC(C)=O,,O=C([O-])O.[K+],,val
US20100075968A1,COc1ccc(N2CC(C(=O)OC(C)(C)C)N(C)C2=O)cn1.O=C(O)C(F)(F)F>>COc1ccc(N2CC(C(=O)O)N(C)C2=O)cn1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04666907,COc1ccc2nc3cc(OC)c(=O)c(Br)c-3sc2c1>>COc1ccc2c(c1)Sc1c(cc(OC)c(O)c1Br)N2,,CCOC(C)=O,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20120041009A1,CCOC(=O)CC(=O)c1ccccc1.N=C(N)C1CC1>>Oc1cc(-c2ccccc2)nc(C2CC2)n1,,CO,,Cl,C[O-].[Na+],val
US20100197683A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(CC(O)C2CCCCC2)c2nc(C)nn12>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(CC(O[Si](C)(C)C(C)(C)C)C2CCCCC2)c2nc(C)nn12,,C1CCOC1,CCOC(C)=O,Cc1cccc(C)n1,,val
US20030092694A1,CNCCOc1ccccc1.Clc1nccnc1Cl>>CN(CCOc1ccccc1)c1nccnc1Cl,,CN(C)C=O,,,,val
US20130005707A1,CNc1cc(Br)ccc1N.O=N[O-]>>Cn1nnc2ccc(Br)cc21,,Cl,,O=C([O-])O.[Na+],,val
US05180418,COC(=O)C1(Sc2cc(N)c(F)cc2Cl)CCC1.O=C1OC(=O)C2=C1CCCC2>>COC(=O)C1(Sc2cc(N3C(=O)C4=CCCCC4C3=O)c(F)cc2Cl)CCC1,,CC(=O)O,,,,val
US06784198B1,C=O.CC(C)c1cnc(NC(=O)Cc2csc(NCCN3CCN(C)CC3)n2)s1>>CC(C)c1cnc(NC(=O)Cc2csc(N(C)CCN3CCN(C)CC3)n2)s1,,ClC(Cl)Cl,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100167986A1,Cc1cc(N)on1.O=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>Cc1cc(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)on1,,Cc1ccccc1,,[BH4-].[Na+],,val
US20140249129A1,CC#N.Cc1cc(C#N)ccc1C(N)C1=C(Nc2cccc(C(F)(F)F)c2)CCCC1=O.O>>Cc1cc(C#N)ccc1C1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)CCC2,,CC#N,,CCN(CC)CC,Cl,val
US20100093757A1,Cc1ccc(NC(=O)[C@H](COCCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)Oc2ncnc3c2cnn3Cc2ccccc2)nc1>>Cc1ccc(NC(=O)[C@H](COCCO)Oc2ncnc3c2cnn3Cc2ccccc2)nc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110118319A1,N#Cc1ccc(C2=NCC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)cc1C(F)(F)F.O=S(=O)(O)O>>O=C(O)c1ccc(C2=NCC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)cc1C(F)(F)F,,O,O=S(=O)(O)O,CC(=O)O,,val
US20060074124A1,COC(=O)C1CCCCC(Br)C1=O.Nc1ccc(Cl)cc1>>COC(=O)C1CCCCc2c1[nH]c1ccc(Cl)cc21,,ClCCl,,O,,val
US20120225867A1,CC1(C)OB(c2ccnn2C2CCCCO2)OC1(C)C.C[C@@H](Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1)NC(=O)c1csc(Br)n1>>C[C@@H](Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1)NC(=O)c1csc(-c2ccnn2C2CCCCO2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,,C1CCOC1,O=C([O-])[O-].[Na+].[Na+],val
US04215062,CC(Cl)Cl.CCOC(=O)CBr.CCOC(=O)CC(=O)[O-]>>CCOC(=O)CC(C(=O)OCC)C(=O)OCC,,C1CCOC1,,[Cl-].[Na+],,val
US20110110889A1,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cc(C(=O)CCl)c3c2)c1F.CNC>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cc(C(=O)CN(C)C)c3c2)c1F,,CCO,,CO,,val
US20160122339A1,Brc1ccc2ncc(I)c(OC[C@@H]3CCCN3)c2c1>>Brc1ccc2ncc3c(c2c1)OC[C@@H]1CCCN31,I[Cu]I,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070167433A1,COCCCN1CCOc2ccc(CO[C@H]3CN(C(=O)OCc4ccccc4)C[C@@H](O)[C@@H]3c3ccc(COCCOC)cc3)cc21.Cc1ccc(S(=O)(=O)OC[C@H]2CO2)cc1>>COCCCN1CCOc2ccc(CO[C@H]3CN(C(=O)OCc4ccccc4)C[C@@H](OC[C@H]4CO4)[C@@H]3c3ccc(COCCOC)cc3)cc21,,C1CCOC1,,[H-].[Na+],,val
US20140088306A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ccc(-c2cnc3ccc(OCCO[Si](C)(C)C(C)(C)C)cc3n2)cc1>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ccc(-c2cnc3ccc(OCCO)cc3n2)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090304692A1,CC(=O)Cl.O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCNCC3)nc(N3CC4CCC(C3)O4)n2)cc1.O=C(O)C(F)(F)F>>CC(=O)N1CCN(c2nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc(N3CC4CCC(C3)O4)n2)CC1.O=C(O)C(F)(F)F,,CCN(CC)CC,ClCCl,O=C(O)C(F)(F)F,,val
US04956359,C1=C(c2ccccc2)CCNC1.O=C(Cl)N1CC(Oc2cccc(C(F)(F)F)c2)C1>>O=C(N1CC=C(c2ccccc2)CC1)N1CC(Oc2cccc(C(F)(F)F)c2)C1,,C1CCOC1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20150148340A1,CCOC(=O)c1cn(-c2cc3[nH]c(=O)[nH]c3cc2C)c(=O)[nH]c1=O.Cc1c(CBr)cccc1C(F)(F)F>>CCOC(=O)c1cn(-c2cc3[nH]c(=O)[nH]c3cc2C)c(=O)n(Cc2cccc(C(F)(F)F)c2C)c1=O,,CCO,,,,val
US20100010015A1,COC(=O)Cl.COc1ccc(C2CCCN(Cc3ccccc3)C2=O)c(OC)c1>>COC(=O)C1(c2ccc(OC)cc2OC)CCCN(Cc2ccccc2)C1=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20120209001A1,CC(C)(C)n1nc(CCCO)cc1-c1ccc(Cl)cc1>>CC(C)(C)n1nc(CCC=O)cc1-c1ccc(Cl)cc1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20110059951A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCC(O)CF>>Cc1ccc(S(=O)(=O)OCC(O)CF)cc1,,ClCCl,,CCN(CC)CC,,val
US20140094607A1,CC[SiH](CC)CC.c1ccc2occc2c1>>CC[Si](CC)(CC)c1cc2ccccc2o1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US05952306,CCOC(=O)C[C@H](NC(=O)CNC(=O)OC(C)(C)C)c1cccnc1.Cl.Cl>>CCOC(=O)C[C@H](NC(=O)CN)c1cccnc1.Cl.Cl,,CCOC(C)=O,,Cl,,val
US20080221193A1,COc1ccc(C(N)=O)c2c1OC[C@H](NCCCc1c[nH]c3ccc(F)cc13)C2.O=C1CCC1>>COc1ccc(C(N)=O)c2c1OC[C@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)C2,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20070185101A1,C=C(C)[C@@H]1CC[C@@H](C)[C@@]2(O)[C@H]1C=C(C)[C@@H](OC(C)=O)[C@@H]2OC(=O)[C@@H]1C[C@@]2(O)c3cccc(Cl)c3N(C)O[C@H]2N1>>CC(=O)O[C@@H]1C(C)=C[C@@H]2[C@H](C(C)C)CC[C@@H](C)[C@]2(O)[C@H]1OC(=O)[C@@H]1C[C@@]2(O)c3cccc(Cl)c3N(C)O[C@H]2N1,[Pt],CC(C)O,,[H][H],,val
US20100105659A1,CC(=O)OC(C)=O.COC(=O)CSc1cnc(Nc2nc(C3CC4CCC(C3)N4)ns2)c(Oc2cccnc2C)c1>>COC(=O)CSc1cnc(Nc2nc(C3CC4CCC(C3)N4C(C)=O)ns2)c(Oc2cccnc2C)c1,,ClCCl,,CCN(CC)CC,,val
US20110287937A1,CCS.COC(=O)c1cc2cccnc2n(CBr)c1=O>>CCSCn1c(=O)c(C(=O)OC)cc2cccnc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060111325A1,CC(OC(=O)OC1CC(=O)NC1=O)OC(=O)C(C)C.CP(=O)(O)CCCN>>CC(OC(=O)NCCCP(C)(=O)O)OC(=O)C(C)C,,CC#N,O,,,val
US20100298336A1,Cc1cc(O)nc(S)n1.Cc1nn(C)c(Cl)c1CBr>>Cc1cc(O)nc(SCc2c(C)nn(C)c2Cl)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050124652A1,[N-]=[N+]=Nc1ccc(C(=O)O)cc1.c1ccc2c(c1)CCCN2>>[N-]=[N+]=Nc1ccc(C(=O)N2CCCc3ccccc32)cc1,,C1CCOC1,,CCN=C=NCCCN(C)C,Cl,val
US20140171408A1,COC(=O)c1c(F)cc(NC(=O)OC(C)(C)C)cc1Cl>>COC(=O)c1c(F)cc(N)cc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150266881A1,CN(Cc1ccccc1)C(=O)c1ccc([C@@H]2C[C@H]2N)cc1.Cl.O=CC1CC1>>CN(Cc1ccccc1)C(=O)c1ccc([C@@H]2C[C@H]2NCC2CC2)cc1.Cl,,C1CCOC1,CO,[BH4-].[Na+],,val
US07402581B2,C=CC[C@H](CNC)c1ccc(F)cc1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=CC[C@H](CN(C)C(=O)OC(C)(C)C)c1ccc(F)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20030176454A1,Cc1ncc(-c2cccc(N)c2)n1C.Clc1nnc(Cl)c2ccccc12>>Cc1ncc(-c2cccc(Nc3nnc(Cl)c4ccccc34)c2)n1C,,c1ccncc1,,,,val
US03933818,CCc1ccc(N)cc1.O=N[O-]>>CCc1ccc(NN)cc1,,O,,Cl,,val
US20100029609A1,Cc1cc(S(=O)(=O)Nc2cccc(-c3ccc(CO)cc3)c2)c(C)cc1Cl>>Cc1cc(S(=O)(=O)Nc2cccc(-c3ccc(C=O)cc3)c2)c(C)cc1Cl,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05397802,CC(=O)Cl.Oc1ccc([C@H]2[C@H](c3ccccc3)C2(Cl)Cl)cc1>>CC(=O)Oc1ccc([C@H]2[C@H](c3ccccc3)C2(Cl)Cl)cc1,,CCO,,,,val
US20110143937A1,CCN(C)C(OC)OC.Cc1cc(Oc2nc(C3(c4ccc(Cl)cc4)CC3)ns2)c(C)cc1N>>CCN(C)C=Nc1cc(C)c(Oc2nc(C3(c4ccc(Cl)cc4)CC3)ns2)cc1C,,Cc1ccccc1,,CO,,val
US06268444B1,CC(C)(C)N[Si](C)(C)Cl.[Li]C1(P(c2ccccc2)c2ccccc2)C=Cc2ccccc21>>CC(C)(C)N[Si](C)(C)C1C=C(P(c2ccccc2)c2ccccc2)c2ccccc21,,C1CCOC1,,,,val
US20070135440A1,BrCc1cccc(CBr)n1.Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(O)cc1>>Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(OCc2cccc(CBr)n2)cc1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20110230458A1,CC(=O)OC1C[C@@H]2CC(=O)CC1N2C>>CC(=O)O[C@@H]1CC2C[C@H](O)CC1N2C,O=[Pt]=O,CCO,,,,val
US20080260649A1,Cc1cc(N(C)C=O)ccc1-n1c(=O)n(-c2ccc(N(C)C=O)cc2C)c(=O)n(-c2ccc(N(C)C=O)cc2C)c1=O>>CNc1ccc(-n2c(=O)n(-c3ccc(NC)cc3C)c(=O)n(-c3ccc(NC)cc3C)c2=O)c(C)c1,,C1COCCO1,,Cl,,val
US20030195144A1,COC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12.COC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C.O=C(O)Cc1c[nH]c2ccccc12>>COC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N,,CO,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05004748,CCC(O)C#Cc1cnc(C(=O)OC)cc1C(=O)OC>>CCC(O)CCc1cnc(C(=O)OC)cc1C(=O)OC,[Pd],CO,,,,val
US20050032786A1,NCc1cccc(-c2nc(=O)c3ccccc3s2)n1.O=S(=O)(Cl)c1ccccc1>>O=c1nc(-c2cccc(CNS(=O)(=O)c3ccccc3)n2)sc2ccccc12,,CCOC(C)=O,O,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20160152621A1,CC(C)CC(NC(=O)OC(C)(C)C)C(=O)Nc1ccc(Br)cc1.OB(O)c1ccncc1>>CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(-c2ccncc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060014816A1,CN1CCNCC1.O=Cc1ccc2c(c1)Cc1c(I)n[nH]c1-2>>CN1CCN(Cc2ccc3c(c2)Cc2c(I)n[nH]c2-3)CC1,,CO,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20110112096A1,Cc1cc([N+](=O)[O-])c(C)cc1C=O.[C-]#[N+]CS(=O)(=O)c1ccccc1C>>Cc1cc([N+](=O)[O-])c(C)cc1-c1cnco1,,CO,,C[O-].[Na+],,val
US20090069288A1,Nc1cc(-c2ccncc2)no1.O=C(Cl)c1ccc(OC(F)(F)F)cc1>>O=C(Nc1cc(-c2ccncc2)no1)c1ccc(OC(F)(F)F)cc1,,CC#N,,c1ccncc1,,val
US20080312286A1,CC1(C2CCCC2)Cc2cc(OCCCC#N)c(Cl)c(Cl)c2C1=O.C[Si](C)(C)N=[N+]=[N-]>>CC1(C2CCCC2)Cc2cc(OCCCc3nnn[nH]3)c(Cl)c(Cl)c2C1=O,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US04835168,CCOC(=O)NC(=S)Nc1nncs1.CI>>CCOC(=O)NC(Nc1nncs1)SC,,[Na+],[OH-],CO,,val
US06326386B1,CC(C)(C)CN(CCC#N)C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1.O=C(O)C(F)(F)F>>CC(C)(C)CN(CCC(N)=O)C(=O)c1cc(Cl)cc(OCCNc2ccncc2)c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20110251173A1,CNCc1ccc(Br)c(Cl)c1.CS(=O)(=O)Cl>>CN(Cc1ccc(Br)c(Cl)c1)S(C)(=O)=O,,ClCCl,,c1ccncc1,,val
US20090082423A1,NCC1CCOCC1.O=C=Nc1ccc(C(F)(F)F)cc1>>O=C(NCC1CCOCC1)Nc1ccc(C(F)(F)F)cc1,,ClCCl,,,,val
US20150166564A1,COCCN1C[C@@H](N)[C@H](c2ccc(F)c(F)c2)C1.Cc1nn(C2CCCCC2)c(NC(=O)Oc2ccccc2)c1C>>COCCN1C[C@@H](NC(=O)Nc2c(C)c(C)nn2C2CCCCC2)[C@H](c2ccc(F)c(F)c2)C1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20040102450A1,COC(=O)C1CN(S(=O)(=O)c2cc3ccc(Cl)cc3s2)CC(=O)N1Cc1ccc(C#N)c(N=C(c2ccccc2)c2ccccc2)c1>>COC(=O)C1CN(S(=O)(=O)c2cc3ccc(Cl)cc3s2)CC(=O)N1Cc1ccc(C#N)c(N)c1,Cl,CO,,C1CCOC1,,val
US20120202862A1,C[C@H](N[C@@H](Cc1ccc(-c2cc(Cl)ccc2Cl)cc1)C(=O)OCc1ccccc1)C(=O)OC(C)(C)C>>C[C@H](N[C@@H](Cc1ccc(-c2cc(Cl)ccc2Cl)cc1)C(=O)O)C(=O)OC(C)(C)C,[Pd],CCOC(C)=O,CO,,,val
US06316444B1,CC(=O)C1CN(C(=O)OC(C)(C)C)CCN1C(=O)OCc1ccccc1>>CC(O)C1CN(C(=O)OC(C)(C)C)CCN1C(=O)OCc1ccccc1,,C1CCOC1,CCO,[BH4-].[Na+],,val
US20140371278A1,C=CCC1(S(=O)(=O)Nc2cc3snnc3c(F)c2Nc2ccc(I)cc2F)CC1.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>O=S(=O)(Nc1cc2snnc2c(F)c1Nc1ccc(I)cc1F)C1(CC(O)CO)CC1,O=[Os](=O)(=O)=O,C1CCOC1,,O,,val
US20140031360A1,CC(C)(C)OC(=O)NC1CCN(c2cncc(-c3c[nH]c4ccc(-c5ccccc5F)nc34)c2)CC1>>NC1CCN(c2cncc(-c3c[nH]c4ccc(-c5ccccc5F)nc34)c2)CC1,,CO,ClCCl,Cl,,val
US07732550B2,C=CC(N)=O.CC(=O)Cl.ClCCl>>C=C(C)C(=O)NC(C)=O,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US06277847B1,COC(=O)c1c(Cl)ccc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c1C.O=C1CCC(=O)N1Br>>COC(=O)c1c(Cl)ccc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c1CBr,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20160107999A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccccc1C#Cc1ccc([N+](=O)[O-])cc1CO>>CC(C)(C)OC(=O)Nc1ccccc1C#Cc1ccc([N+](=O)[O-])cc1CO,,C1CCOC1,ClCCl,,,val
US05302724,NS(=O)(=O)c1cccs1.O=C=Nc1ccc(Cl)c(Cl)c1>>O=C(Nc1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1,,CC(C)=O,,Cl,[Na+].[OH-],val
US20090221607A1,CC(C)(C)OC(=O)N1CCNCC1.Fc1ccc(OCCBr)cc1>>CC(C)(C)OC(=O)N1CCN(CCOc2ccc(F)cc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080096861A1,CC(C)(C)OC(=O)N1CCC(Nc2ccccc2NC(=O)CNC(=O)OCc2ccccc2)CC1>>CC(C)(C)OC(=O)N1CCC(n2c(CNC(=O)OCc3ccccc3)nc3ccccc32)CC1,,CC(=O)O,,,,val
US20090312381A1,CCOC(=O)CCl.Cc1csc(-c2n[nH]c(=O)n2CC(C)C)c1Cl>>CCOC(=O)Cn1nc(-c2scc(C)c2Cl)n(CC(C)C)c1=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05300514,Clc1ccc2nc(Cl)sc2c1.O=C1NNC(c2ccccc2)C1c1ccccc1>>O=C1NN(c2nc3ccc(Cl)cc3s2)C(c2ccccc2)C1c1ccccc1,,Cc1ccccc1,,Cl,[H-].[Na+],val
US20090082356A1,COc1ccc(OC)c(Nc2nc3ccccc3nc2N)c1.Cn1cnc(S(=O)(=O)Cl)c1>>COc1ccc(OC)c(Nc2nc3ccccc3nc2NS(=O)(=O)c2cn(C)cn2)c1,,c1ccncc1,,,,val
US20080039459A1,Clc1nc(N2CCOCC2)c2sccc2n1.II>>Clc1nc(N2CCOCC2)c2sc(I)cc2n1,,C1CCOC1,CCCCCC,,,val
US20060111347A1,CC1(C)O[C@H](CS(=O)(=O)c2ccc3ccccc3c2)[C@H](C(=O)N[C@@H]2CCCc3cc(C=O)ccc32)O1.CC1CCCC(C)N1>>CC1CCCC(C)N1Cc1ccc2c(c1)CCC[C@H]2NC(=O)[C@@H]1OC(C)(C)O[C@@H]1CS(=O)(=O)c1ccc2ccccc2c1,CC(=O)O,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20150291595A1,Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(Br)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12.O=S(=O)(c1cccc(B(O)O)c1)N1CCOCC1>>Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cccc(S(=O)(=O)N5CCOCC5)c3)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20140163012A1,Cl.O=C1CN(CCc2ccc(Cl)cc2)CCN1c1ccc2c3c(oc2c1)CCNC3>>Cl.O=C1CN(CCc2ccc(Cl)cc2)CCN1c1ccc2c3c(oc2c1)CCNC3,,CO,,CCOCC,,val
US20120252780A1,CCOC(=O)C(C)(C)Br.O=[N+]([O-])c1nc(Br)ccc1O>>CCOC(=O)C(C)(C)Oc1ccc(Br)nc1[N+](=O)[O-],,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120077828A1,Cn1nc(-c2ccc3c(c2)CCN3)c2c(N)ncnc21.O=C(O)Cc1ccccc1F>>Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2ccccc2F)c2c(N)ncnc21,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150210682A1,CC(=O)OC(C)=O.CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCCCCN)cc1CC2C(C)(C)C>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCCCCNC(C)=O)cc1CC2C(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20050245529A1,ClC/C=C/c1ccc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)cc1.OC1(C(F)(F)F)CCNCC1>>OC1(C(F)(F)F)CCN(C/C=C/c2ccc(C#Cc3ccc(-c4ccc(Cl)cc4)cn3)cc2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05760021,C=C(C(=O)OCC)P(=O)(OCC)OCC.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)C1(P(=O)(OCC)OCC)CO1,,ClCCl,,O=C([O-])O.[Na+],,val
US20070099990A1,Cc1c(NCc2ccccc2)c2c(c3c1C(c1ccc(C(C)C)cc1)CO3)CCCC2>>Cc1c(N)c2c(c3c1C(c1ccc(C(C)C)cc1)CO3)CCCC2,,CCCCCC,CCOC(C)=O,,,val
US20150232459A1,COC(=O)NCCCn1nc([C@@H](C)N(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CCO2)C2CC2)cc1-c1ccccn1>>COC(=O)NCCCn1nc([C@@H](C)N(C(=O)[C@H]2CNCCO2)C2CC2)cc1-c1ccccn1,,ClCCl,,,,val
US20100029633A1,CC(C)(C)OC(=O)N1CCC(=O)C(F)C1>>CC(C)(C)OC(=O)N1CCC(O)C(F)C1,,CO,,[BH4-].[Na+],,val
US20060058348A1,CC(C)(C)OC(=O)N1CCC(CO)C1>>CC(C)(C)OC(=O)N1CCC(C=O)C1,,ClCCl,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US20100256188A1,CC(C)(C)OC(=O)NCc1ccc(C(F)(F)F)c(N)c1>>NCc1ccc(C(F)(F)F)c(N)c1,,C1CCOC1,,Cl,,val
US20160272585A1,COC(=O)c1ccc([C@H](C)NC(=O)[C@H]2CCCN2)cc1.Fc1ccc(OCCBr)cc1>>COC(=O)c1ccc([C@H](C)NC(=O)[C@H]2CCCN2CCOc2ccc(F)cc2)cc1,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US06174881B1,NC1=Nc2ccc(Cl)cc2C(c2ccccc2F)=NC1.O=C(CCl)CCl>>OCc1cn2c(n1)CN=C(c1ccccc1F)c1cc(Cl)ccc1-2,,C1COCCO1,,[Na+].[OH-],,val
US20110152240A1,CC(C)CN.O=C1NC(=O)C(=Cc2cnn3c(NC4CC4)cc(Cl)nc23)S1>>CC(C)CNc1cc(NC2CC2)n2ncc(C=C3SC(=O)NC3=O)c2n1,,CN1CCCC1=O,CO,,,val
US03988471,C=C(C)c1ccccc1.CC(C)(C)c1cc(C(=S)S)cc(C(C)(C)C)c1O>>CC(C)(C)c1cc(C(=S)SC(C)(C)c2ccccc2)cc(C(C)(C)C)c1O,,Cc1ccccc1,,,,val
US20010051631A1,CC(C)(C)OC(=O)N(CCCCNC(=O)C(F)(F)C(F)(F)F)Cc1cccc2ncc(C(=O)C(Cl)(Cl)Cl)n12>>O=C1c2cnc3cccc(n23)CN1CCCCNC(=O)C(F)(F)C(F)(F)F,,CCO,,Cl,,val
US20150011574A1,CC(C)(C)OC(=O)CCC(=O)Nc1ncc(C(=O)NCc2ccc(Cl)cc2Cl)c(O)n1>>O=C(O)CCC(=O)Nc1ncc(C(=O)NCc2ccc(Cl)cc2Cl)c(O)n1,,O=C(O)C(F)(F)F,,CCOCC,,val
US20120295903A1,CC(C)(C)OC(=O)C1CCN(CCn2c3nc(=O)[nH]c(=O)c-3nc3ccccc32)CC1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C(O)C1CCN(CCn2c3nc(=O)[nH]c(=O)c-3nc3ccccc32)CC1,,ClCCl,,,,val
US20070197621A1,BrP(Br)Br.CCC(O)c1ccc(C)cc1>>CCC(Br)c1ccc(C)cc1,,CCOCC,,c1ccncc1,,val
US05234918,CCCCCCCCCCCCCCCCOCC(O)COC(c1ccccc1)(c1ccccc1)c1ccc(OC)cc1.O=C(O)CCl>>CCCCCCCCCCCCCCCCOCC(CO)OCC(=O)O,,Cc1ccccc1,,O,[H-].[Na+],val
US20140315888A1,COC(OC)OC.NNc1nc2cc(Br)cnc2nc1N1CCN2CCCC2C1>>Brc1cnc2nc(N3CCN4CCCC4C3)c3nncn3c2c1,,CCOCC,,,,val
US20090048320A1,CCN(CC)S(F)(F)F.O=C(C(=O)c1cccc(C#CCO)c1)c1ccc(OC(F)F)cc1>>O=C(C(=O)c1cccc(C#CCF)c1)c1ccc(OC(F)F)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20100087424A1,CCCCOC(=O)/C=C/c1c(F)ccc2ccc(OC)nc12>>CCCCOC(=O)CCc1c(F)ccc2ccc(OC)nc12,[Pd],CCO,,[H][H],,val
US20010031746A1,CCOP(=O)(CC(=O)Cl)OCC.Nc1cc(Cl)ccc1C=O>>CCOP(=O)(CC(=O)Nc1cc(Cl)ccc1C=O)OCC,,Cc1ccccc1,,c1ccncc1,,val
US05489606,CSCCl.C[C@@H](S)[C@](O)(Cn1cncn1)c1ccc(F)cc1F>>CSCS[C@H](C)[C@](O)(Cn1cncn1)c1ccc(F)cc1F,,CCCCCC,CN(C)C=O,[H][H],[H-].[Na+],val
US20050148572A1,COC(=O)[C@H](N)CC(C)C.O=C(N[C@@H](C(=O)O)C1Cc2ccccc2C1)OCc1ccccc1.O=Cc1ccc(F)cc1F.[C-]#[N+]c1ccccc1OCc1ccccc1>>CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1C(C(=O)Nc1ccccc1O)c1ccc(F)cc1F,,CCN(CC)CC,,CO,Cl,val
US20110294776A1,CC(C)(C)OC(=O)N1CCC(Cc2cc(Br)c3c(N)ncnn23)C1.CC1(C)OB(c2ccc3cn(Cc4ccccc4)nc3c2)OC1(C)C>>CC(C)(C)OC(=O)N1CCC(Cc2cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c3c(N)ncnn23)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],,val
US05750549,CCOC(=O)c1sc(-c2ccncc2)nc1OC>>COc1nc(-c2ccncc2)sc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030236230A1,O=C(O)CCc1ccc(Cl)cc1.O=S(Cl)Cl>>O=C(Cl)CCc1ccc(Cl)cc1,,c1ccccc1,,,,val
US06137007,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@H]1C=C[C@@H](CO)C1>>CC(C)(C)OC(=O)[C@]1(N)C=C[C@@H](CO)C1,,CC(C)OC(C)C,,[Na+].[OH-],,val
US20050043278A1,CCOC(=O)CCC(C)(C)CCCC(=O)CCCCCC(C)(C)C(=O)OCC>>CCOC(=O)CCC(C)(C)CCCC(O)CCCCCC(C)(C)C(=O)OCC,,CC(C)O,O,[BH4-].[Na+],,val
US20130109653A1,COC(=O)c1cccc(B(O)O)c1.Clc1ncc(Br)cn1>>COC(=O)c1cccc(-c2cnc(Cl)nc2)c1,,Cc1ccccc1,,O,O=C([O-])[O-].[K+].[K+],val
US20160152616A1,CC1(C)CCn2c(=O)[nH]c3cccc1c32.CC1(C)OC[C@H](/C=C/CBr)O1>>CC1(C)OC[C@H](/C=C/Cn2c(=O)n3c4c(cccc42)C(C)(C)CC3)O1,,CN(C)C=O,,O,[H-].[Na+],val
US20070054916A1,Cc1c(Cl)cc([N+](=O)[O-])cc1-c1ccc2nc(N)ncc2c1>>Cc1c(Cl)cc(N)cc1-c1ccc2nc(N)ncc2c1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20070155813A1,C1COCCN1.C=O.COC(=O)Cc1cc(O)cc(O)c1-c1ccccc1>>COC(=O)Cc1c(CN2CCOCC2)c(O)cc(O)c1-c1ccccc1,,CC(C)O,,,,val
US20050282891A1,C[C@@H](OC(=O)[C@H](Cc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1)NC(=O)OC(C)(C)C)[C@@H](C)OC(=O)c1ccccc1>>C[C@@H](OC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)OC(C)(C)C)[C@@H](C)OC(=O)c1ccccc1,[Pd],C1CCOC1,,CO,,val
US20070082912A1,CC(=O)CCC(=O)c1cc(Cl)ccc1OCc1ccc(Br)cc1F.Nc1cc(Br)cc(C(=O)O)c1>>Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(Br)cc2F)n1-c1cc(Br)cc(C(=O)O)c1,,CC#N,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,,val
US04968682,CC(C)Nc1ncccc1N.CCOC(=O)C(=O)Cl>>CC(C)n1c(=O)c(=O)[nH]c2cccnc21,,C1CCOC1,,CCN(CC)CC,,val
US20120277224A1,COC(=O)CC(=O)c1ccc2c(c1)OCCO2.Nc1[nH]ncc1-c1ccc(N2CCCCC2)nc1>>O=c1cc(-c2ccc3c(c2)OCCO3)[nH]c2c(-c3ccc(N4CCCCC4)nc3)cnn12,,CC(=O)O,,,,val
US20080045521A1,C=CCB1OC(C)(C)C(C)(C)O1.CC(C)(C)OC(=O)N1CCOc2ccc(Br)nc21>>C=CCc1ccc2c(n1)N(C(=O)OC(C)(C)C)CCO2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,,[Cs+].[F-],,val
US05849928,CC(=O)Nc1ccc(S(F)(F)(F)(F)F)cc1.O=[N+]([O-])O>>CC(=O)Nc1ccc(S(F)(F)(F)(F)F)cc1[N+](=O)[O-],,CC(=O)O,,O=S(=O)(O)O,,val
US20140121198A1,COC(=O)[C@H]1CC=CC[C@H]1NC(=O)OCc1ccccc1.O=C(OO)c1cccc(Cl)c1>>COC(=O)[C@H]1C[C@H]2O[C@H]2C[C@H]1NC(=O)OCc1ccccc1,,ClCCl,ClCCl,,,val
US05336778,C1CCOC1.CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(N)cc1.N#Cc1ccccc1CCl>>CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C#N)cc1,,CCCCCC,,CCN(C(C)C)C(C)C,,val
US06329381B1,BrCc1ccccc1.Nc1nc(N)c2[nH]cnc2n1>>Nc1nc(N)c2ncn(Cc3ccccc3)c2n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20030065182A1,CCC1=C(C(=O)OC)C(c2ccc(F)c(I)c2)C2=C(COCC2=O)N1.ClC(Cl)Cl.O=C1CCC(=O)N1Br>>C[C@@H]1OC(=O)C2=C1NC1=C(C(=O)COC1)[C@@H]2c1ccc(F)c(I)c1,,ClC(Cl)Cl,,,,val
US20140065103A1,COC(=O)c1sc(C#CC(C)C)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C1CCN(C(=O)CCCCCNC(=O)OC(C)(C)C)CC1>>CC(C)C#Cc1cc(N(C(=O)[C@@H]2CC[C@@H](C)CC2)C2CCN(C(=O)CCCCCNC(=O)OC(C)(C)C)CC2)c(C(=O)O)s1,,O,,CO,[Li+].[OH-],val
US20140256933A1,Cl.NC1=N[C@@]2(c3ccc(F)s3)CN(c3ncccn3)C[C@H]2CS1>>Cl.NC1=N[C@@]2(c3ccc(F)s3)CN(c3ncccn3)C[C@H]2CS1,,CCOCC,ClCCl,,,val
US04614742,C=C(C)CO.N#Cc1c(F)c(F)c(F)c(C#N)c1F>>C=C(C)COc1c(F)c(F)c(C#N)c(F)c1C#N,,CC#N,,[F-].[K+],,val
US20120208819A1,C[C@H](NC(=O)c1c(Cl)ncc(Br)c1N)c1ccc(F)c(F)c1.NCc1cccs1>>C[C@H](NC(=O)c1c(NCc2cccs2)ncc(Br)c1N)c1ccc(F)c(F)c1,,CCCCCO,,O=C([O-])O.[Na+],,val
US20110046110A1,C1CCNC1.CC(C)(C)OC(=O)Nc1cccc(COS(C)(=O)=O)n1>>CC(C)(C)OC(=O)Nc1cccc(CN2CCCC2)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20080312209A1,CC(Cl)OC(=O)N1CC(=O)C1.Nc1ccc(F)cc1>>Fc1ccc(NC2CNC2)cc1,,ClCCCl,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160185778A1,COC(=O)C1(C)CCCC1>>CC1(C(=O)O)CCCC1,,CO,,O,[Na+].[OH-],val
US20110118230A1,C=O.CC(C)(C)OC(=O)N1CCC(c2cccc(Br)c2)CC1>>CN1CCC(c2cccc(Br)c2)CC1,,O=CO,,,,val
US05637718,C=CC(C)(C)CC(=O)OC>>C=CC(C)(C)CC(=O)O,,CCO,,[K+].[OH-],,val
US04324741,CS(=O)(=O)O.O=C(OI(OC(=O)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)F.c1ccccc1>>CS(=O)(=O)[O-].FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)[I+]c1ccccc1,,O=C(O)C(F)(F)F,,,,val
US20100069360A1,NO.O=C1CCCc2[nH]c3c(ccc4cnc(Cl)cc43)c21>>ON=C1CCCc2[nH]c3c(ccc4cnc(Cl)cc43)c21,,CCO,,Cl,c1ccncc1,val
US20010034352A1,CC(C)(C)OC(=O)NC1CCN(CCc2coc3ccccc23)CC1>>NC1CCN(CCc2coc3ccccc23)CC1,,CCO,,Cl,,val
US04091108,O=C(O)c1ccc2c(c1)Sc1ccccc1O2.OO>>O=C(O)c1ccc2c(c1)S(=O)c1ccccc1O2,,CCO,,,,val
US20100056516A1,Nc1ccccc1.O=c1cc(OS(=O)(=O)C(F)(F)F)c2cccnc2n1OCc1ccccc1>>O=c1cc(Nc2ccccc2)c2cccnc2n1OCc1ccccc1,,CN(C)C=O,,,,val
US08129361B2,CCc1ccc(CCCOc2ccc(CCC3(NC(=O)OC(C)(C)C)COC(C)(C)OC3)cc2C(F)(F)F)cc1.Cl>>CCc1ccc(CCCOc2ccc(CCC(N)(CO)CO)cc2C(F)(F)F)cc1.Cl,,CCO,,,,val
US20130317024A1,COC(=O)c1cc(Br)n(C(C)C)c1C(Nc1ccc(F)c(Cl)c1)c1ccc(Cl)cc1>>CC(C)n1c(Br)cc(C(=O)O)c1C(Nc1ccc(F)c(Cl)c1)c1ccc(Cl)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20100168122A1,CCCCn1c(=O)n(CCCCC(=O)OCC)c(=O)c2[nH]c(Cl)nc21.N=C(NO)c1ccccn1>>CCCCn1c(=O)n(CCCCc2nc(-c3ccccn3)no2)c(=O)c2[nH]c(Cl)nc21,,CCO,,C,C[O-].[Na+],val
US05925676,C=CC[Mg]Cl.CC(C)(C)[Si](C)(C)OC1C=CC(=O)C1>>C=CCC1(O)C=CC(O[Si](C)(C)C(C)(C)C)C1,,CCOCC,,C1CCOC1,[Cl-].[NH4+],val
US20130237535A1,CI.Oc1c(Br)ccc2cccnc12>>COc1c(Br)ccc2cccnc12,,CN(C)C=O,,[H-].[Na+],,val
US04065617,CCCCN1CC(=Cc2ccccc2)C2=NN(CC(F)(F)F)C(c3ccccc3)C2C1.O=C(O)/C=C\C(=O)O>>CCCCN1CC(=Cc2ccccc2)C2=NN(CC(F)(F)F)C(c3ccccc3)C2C1.O=C(O)/C=C\C(=O)O,,CC#N,CCOCC,,,val
US20040058978A1,CCOC(=C1C(=O)N(C(C)=O)c2ccc([N+](=O)[O-])cc21)c1ccccc1>>CCOC(=C1C(=O)Nc2ccc([N+](=O)[O-])cc21)c1ccccc1,,CCO,ClCCl,[Na+].[OH-],,val
US20120264735A1,N#Cc1cncc(-n2ccc(=O)c(CO)n2)c1.O=S(Cl)Cl>>N#Cc1cncc(-n2ccc(=O)c(CCl)n2)c1,,CC#N,,,,val
US20090142316A1,O=Cc1ccc(O)cc1>>O=Cc1ccccc1O,,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100160308A1,COC(OC)c1ccc([N+](=O)[O-])c(F)c1.NC(=O)c1sc(N)nc1-c1ccccc1Cl>>COC(OC)c1ccc([N+](=O)[O-])c(Nc2nc(-c3ccccc3Cl)c(C(N)=O)s2)c1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US05380718,CCOC(=O)CBr.O=C1c2ccc(F)cc2CC1c1ccc(F)cc1>>CCOC(=O)CC1(c2ccc(F)cc2)Cc2cc(F)ccc2C1=O,,CN(C)C=O,,Cl,[H-].[Na+],val
US04977273,COC(=O)C(F)(F)Cc1c[nH]c([N+](=O)[O-])n1.NCC(F)(F)C(N)=O>>NC(=O)C(F)(F)CNC(=O)C(F)(F)Cc1c[nH]c([N+](=O)[O-])n1,,CO,,,,val
US20060258728A1,CC(C)CC(NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1ccc(F)cc1.N>>CC(C)CC(NC(=O)c1cc(COc2ccccc2)ccc1CCC(N)=O)c1ccc(F)cc1,,C1CCOC1,O,CCN(CC)CC,CCOC(=O)Cl,val
US20070099990A1,CC(C)c1ccc(C(O)C(=O)O)cc1.Oc1ccc(Br)cc1>>CC(C)c1ccc(C2C(=O)Oc3ccc(Br)cc32)cc1,,CO,,,,val
US20130237571A1,CCOC(=O)CCc1ccc(-c2ccc(OC)cc2)cc1>>CCOC(=O)CCc1ccc(-c2ccc(O)cc2)cc1,,ClCCl,,,,val
US20070219182A1,COC(=O)CCCN1C(=O)CCC(=O)c2ccccc21>>O=C(O)CCCN1C(=O)CCC(=O)c2ccccc21,,CO,O,[Na+].[OH-],,val
US20060014797A1,BrBr.Cc1ccc2cc(CCN(C)C)sc2c1>>Cc1ccc2c(Br)c(CCN(C)C)sc2c1,,CC(=O)O,,COC(C)(C)C,,val
US20040186091A1,CCN(CC)CC.Clc1ccc2c(c1)CNCc1nnc(C3CCN(c4ccccn4)CC3)n1-2.O=C(Cl)CCl>>N.O=C(CCl)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1,,ClCCl,,,,val
US20090197884A1,C=CCO[C@@H]1CNC[C@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1.O=C1CCN(c2ccc(C(=O)N3CCOCC3)cc2)CC1>>C=CCO[C@@H]1CN(C2CCN(c3ccc(C(=O)N4CCOCC4)cc3)CC2)C[C@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080255162A1,COC(=O)c1cc(Nc2nc(C)c3cc(C)c(=O)n(Cc4ccc(OC)cc4)c3n2)cn1C>>COc1ccc(Cn2c(=O)c(C)cc3c(C)nc(Nc4cc(C(=O)O)n(C)c4)nc32)cc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20110257137A1,CCOC(=O)C[N+](=O)[O-].O=c1[nH]c2ccc(Cl)cc2c(=O)o1>>O=c1[nH]c2ccc(Cl)cc2c(O)c1[N+](=O)[O-],,C1CCOC1,,CCN(CC)CC,,val
US20020132810A1,CC(=O)OC(CC(CCC(C)(C)F)C(=N)N)C(Cc1ccccc1)NC(=O)c1cnc2ccccc2n1>>CC(C)(F)CCC(CC(O)C(Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=N)N,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20070287725A1,Nc1nc2cccnc2c2c1ncn2Cc1cc(-c2ccc(F)cc2)no1>>Nc1nc2c(c3c1ncn3Cc1cc(-c3ccc(F)cc3)no1)NCCC2,O=[Pt]=O,,,O=C(O)C(F)(F)F,,val
US20080015222A1,N#Cc1cccc([N+](=O)[O-])c1Cl.NCCO>>N#Cc1cccc([N+](=O)[O-])c1NCCO,,CCO,,,,val
US20110028487A1,NC(=O)c1ccccc1C(N)=O.O=C(CCl)Cc1ccc(F)cc1>>O=C(Cc1ccc(F)cc1)CN1C(=O)c2ccccc2C1=O,,CN(C)C=O,,[K],,val
US20090209524A1,CCOC(=O)CC(C)=O.COC(=O)c1ccc(CBr)c(OC)c1>>CCOC(=O)C(Cc1ccc(C(=O)OC)cc1OC)C(C)=O,,C1CCOC1,,[H-].[Na+],,val
US20070191309A1,COc1ccc2c(c1)N(C(=O)OC(C)(C)C)[C@@H](OC1CCCCO1)[C@@H]1C(OCCCCOC3CCN4C(=O)c5ccc(OC)cc5N(C(=O)OC(C)(C)C)[C@@H](OC5CCCCO5)[C@H]34)CCN1C2=O>>COc1ccc2c(c1)N=C[C@H]1C(OCCCCOC3CCN4C(=O)c5ccc(OC)cc5N=C[C@@H]34)CCN1C2=O,,CO,ClC(Cl)Cl,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20070254866A1,CCN(CC)CC.NCc1ccccc1.O=C([O-])c1cn(C2CCOCC2)c2cc(F)c(F)c(F)c2c1=O>>CCOC(=O)c1cn(C2CCOCC2)c2cc(F)c(F)c(NCc3ccccc3)c2c1=O,,Cc1ccccc1,,O,,val
US20090042890A1,CCOC(=O)c1nc(-c2cccc(O)c2)nc(NC2CCN(C(=O)OC(C)(C)C)CC2)c1N.CCOC(=O)c1nc(-c2cccc(O)c2)nc2c1[nH]c(=O)n2C1CCN(C(=O)OC(C)(C)C)CC1>>NC(=O)c1nc(-c2cccc(O)c2)nc2c1[nH]c(=O)n2C1CCNCC1,,ClCCl,,,,val
US20160009704A1,CC(C)(C)OC(=O)c1cn(C[C@H](F)CO)nn1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC[C@@H](F)Cn2cc(C(=O)OC(C)(C)C)nn2)cc1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,,,val
US20110144136A1,CC(C)(C)OC(=O)N1CCC(CCCCBr)CC1.COc1nc2nc(OC(C)C)[nH]c(N)c-2n1>>COc1nc2c(N)nc(OC(C)C)nc2n1CCCCC1CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US04179452,CC(C)C(O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.O=P(Cl)(Cl)Cl>>CC(C)=CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(Cl)CC[C@]4(C)[C@H]3CC[C@]12C,,c1ccncc1,,,,val
US20140275083A1,C=C(C)c1ccc([C@H](C)N)c(F)c1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=C(C)c1ccc([C@H](C)NC(=O)OC(C)(C)C)c(F)c1,,O,,CN1CCCC1=O,,val
US05021430,CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)C[C@H](Cc1ccccc1)C(=O)OCOC(=O)C(C)(C)C)C(=O)OCc1ccccc1>>CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)C[C@H](Cc1ccccc1)C(=O)OCOC(=O)C(C)(C)C)C(=O)O,[Pd],CCO,,,,val
US06372770B1,COc1ccc(Cc2nc3cc(Cl)cc(CC=O)c3o2)cc1OC1CCCC1>>COc1ccc(Cc2nc3cc(Cl)cc(CCO)c3o2)cc1OC1CCCC1,,CCO,,O,[BH4-].[Na+],val
US20140296203A1,C=C(C)c1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c2cc(Cl)ncc12.C[Si](C)(C)C(F)(F)F>>CC1(c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc(Cl)ncc23)CC1(F)F,,C1CCOC1,,[I-].[Na+],,val
US20110136789A1,Cc1ccc(-n2nnnc2-c2cccnc2NC(C)(C)C)c(F)c1F>>Cc1ccc(-n2nnnc2-c2cccnc2N)c(F)c1F,,CO,,Cl,[Na+].[OH-],val
US20130338142A1,Brc1cn2ccnc2c(Br)n1.Nc1ccc(N2CCN(C3COC3)CC2)cc1>>Brc1cn2ccnc2c(Nc2ccc(N3CCN(C4COC4)CC3)cc2)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20140179689A1,Fc1ccc2cc[nH]c2c1.Nc1nccc(Cl)n1>>Nc1nccc(-n2ccc3ccc(F)cc32)n1,,CN1CCCC1=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100256097A1,CC(C)(C)OC(=O)N1CC(O)C1.Cc1nc(Cl)ccc1CBr>>Cc1nc(Cl)ccc1COC1CN(C(=O)OC(C)(C)C)C1,,C1CCOC1,O,Cl,[H-].[Na+],val
US04052393,CCOC(=O)c1cnn2c1c(Cl)nc1ccccc12.CS>>CCOC(=O)c1cnn2c1c(SC)nc1ccccc12,,CN(C)C=O,,O,[Na],val
US20070208005A1,CNC(=O)c1cnc(Cc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)CC3)cn1>>CNC(=O)c1cnc(Cc2ccc3c(c2)CCNCC3)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100292236A1,CC(=O)O.CCOC(=O)c1c[nH]nc1O>>CCOC(=O)c1cn(C(C)=O)nc1O,,CC(=O)O,,CC(=O)OC(C)=O,,val
US05576324,Cc1cc2c(c3ccc(=O)[nH]c13)OC(CN)C2.N#CBr>>Cc1cc2c(c3ccc(=O)[nH]c13)OC(CNC#N)C2,,C1CCOC1,,,,val
US20130059832A1,CC(C)(C)OC(=O)N1CC(C(=O)O)C1.NC(=NO)c1ccc(F)c(NC(=O)c2cnc3ccccn23)c1>>CC(C)(C)OC(=O)N1CC(c2nc(-c3ccc(F)c(NC(=O)c4cnc5ccccn45)c3)no2)C1,,CN1CCCC1=O,,O=C(n1ccnc1)n1ccnc1,,val
US20160251339A1,O=C(N1CCN(c2cc(S(=O)(=O)n3ccc4ccc(F)cc43)ccc2OCC(F)(F)C(F)F)CC1)C(Cl)(Cl)Cl>>O=S(=O)(c1ccc(OCC(F)(F)C(F)F)c(N2CCNCC2)c1)n1ccc2ccc(F)cc21,,C1CCOC1,,[K+].[OH-],,val
US20100004238A1,C[Si](C)(C)C(F)(F)F.O=C1CCc2c(Oc3ccc([N+](=O)[O-])cc3Cl)cccc21>>O=[N+]([O-])c1ccc(Oc2cccc3c2CCC3(O)C(F)(F)F)c(Cl)c1,,C1CCOC1,O,Cl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20130064770A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.O=[N+]([O-])c1cccc(Cl)n1>>CC(C)(C)OC(=O)N1CC=C(c2cccc([N+](=O)[O-])n2)CC1,,CN(C)C=O,,,,val
US20120077812A1,CS(=O)(=O)c1ccc(-c2ccc(OCC3CCN(C#N)CC3)cc2)cc1.NO>>CS(=O)(=O)c1ccc(-c2ccc(OCC3CCN(C(=N)NO)CC3)cc2)cc1,,CCO,,Cl,,val
US20130059883A1,CS(=O)(=O)Cl.OCCCc1nc(-c2ccccc2)cs1>>CS(=O)(=O)OCCCc1nc(-c2ccccc2)cs1,,c1ccncc1,,,,val
US05001125,FC(F)(F)c1cccc(N2CCNCC2)c1.Ic1ccc(I)nn1>>FC(F)(F)c1cccc(N2CCN(c3ccc(I)nn3)CC2)c1,,CC(=O)N(C)C,,O=C([O-])[O-].[Na+].[Na+],,val
US20020007071A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cccc2c1nc(COc1ccc(N)cc1)n2CCCC1CCCN(C(=O)OC(C)(C)C)C1>>Cc1cccc2c1nc(COc1ccc(NC(=O)OC(C)(C)C)cc1)n2CCCC1CCCN(C(=O)OC(C)(C)C)C1,,O,,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US06403610B1,ClCCBr.Sc1nccs1>>ClCCSc1nccs1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070167444A1,C=CC(=O)OC.O=Cc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>C=C(C(=O)OC)C(O)c1ccc([N+](=O)[O-])cc1[N+](=O)[O-],,C1COCCO1,O,C1CN2CCN1CC2,,val
US20120202777A1,Brc1ccc(CCI)cc1.CCOC(=O)C(C)S(C)(=O)=O>>CCOC(=O)C(C)(CCc1ccc(Br)cc1)S(C)(=O)=O,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150119402A1,CI.O=C(c1cccnc1NCc1ccccc1)c1c[nH]c2cc(Cl)ccc12>>Cn1cc(C(=O)c2cccnc2NCc2ccccc2)c2ccc(Cl)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20060211734A1,CC1CC(Oc2cccc(NC(=O)c3ccc(F)cc3Cl)c2)CCN1C(=O)OC(C)(C)C>>CC1CC(Oc2cccc(NC(=O)c3ccc(F)cc3Cl)c2)CCN1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20150065507A1,Cc1cc(C(C)C)cnc1N(CC(C)C)S(=O)(=O)c1ccc(OC[C@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2F)cc1>>Cc1cc(C(C)C)cnc1N(CC(C)C)S(=O)(=O)c1ccc(OC[C@H]2CCNC[C@H]2F)cc1,,O=C(O)C(F)(F)F,,ClCCl,,val
US04006179,CCO.O=C(O)CCCCCCCCC1=CCCC1=O>>CCOC(=O)CCCCCCCCC1=CCCC1=O,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05883049,BrC1CCCC1.Cc1cc(Cl)c(N2C(=O)C3=CCCCN3C2=O)cc1O>>Cc1cc(Cl)c(N2C(=O)C3=CCCCN3C2=O)cc1OC1CCCC1,,CC#N,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccco2)c1C#N.NCCNc1ccc(Cl)cn1>>N#Cc1c(NCCNc2ccc(Cl)cn2)nc(N)nc1-c1ccco1,,COCCOC,,C1CCC2=NCCCN2CC1,Cl,val
US20040162435A1,CCCCC/C=C\C/C=C\CCCCCCCC(=O)OCC.CN1CCCC1CCN>>CCCCC/C=C\C/C=C\CCCCCCCC(=O)NCCC1CCCN1C,,CCOC(C)=O,O,Cc1ccccc1,[Na+].[OH-],val
US20060116376A1,CC(C)(C)OC(=O)N1CCCC(C)(C(Oc2n[nH]c3ccc(F)cc23)c2ccccc2F)C1.Cl>>CN1CCCC(COc2nn(-c3ccccc3F)c3ccc(F)cc23)C1.Cl,,C1COCCO1,CCOC(C)=O,,,val
US20030092712A1,CSc1nc(Cl)c(C)c(-c2ccc(F)cc2F)n1.O=C1CCC(=O)N1Br>>CSc1nc(Cl)c(CBr)c(-c2ccc(F)cc2F)n1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20110053909A1,CC(C)c1nc(C(=O)N2CCOC3(CCN(CCOc4ccccc4CCOCCC(=O)O)CC3)C2)cs1.CCCCNCC(OC)OC>>CCCCN(CC(OC)OC)C(=O)CCOCCc1ccccc1OCCN1CCC2(CC1)CN(C(=O)c1csc(C(C)C)n1)CCO2,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110201643A1,O=C(NOC1CCCCO1)c1ccc2c(c1)CNCC2.O=C(O)Cc1cccnc1>>O=C(NOC1CCCCO1)c1ccc2c(c1)CN(C(=O)Cc1cccnc1)CC2,,CCN(CC)CC,CN(C)C=O,ClCCCl,On1nnc2ccccc21,val
US04636512,CC(=O)Nc1nccs1.CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)c1nc2c(C(F)(F)F)cccc2c(=O)o1>>CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1c(C(=O)CC(=O)Nc2nccs2)cccc1C(F)(F)F,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20110224188A1,O=C(NC1(C(=O)NC2(c3cocn3)CC2)CC1)OCc1ccccc1>>NC1(C(=O)NC2(c3cocn3)CC2)CC1,[Pd],CO,,,,val
USH0002007H1,C=O.Clc1ccc(C(c2ccccc2Cl)N2CCNCC2)cc1.Clc1cccc2[nH]ccc12>>Clc1ccc(C(c2ccccc2Cl)N2CCN(Cc3c[nH]c4cccc(Cl)c34)CC2)cc1,,C1COCCO1,CC(=O)O,O=C([O-])O.[Na+],,val
US20060258648A1,CC(C)(C)[Si](C)(C)OCCCO.Cc1c(CNC2CC2)ccnc1Cl>>Cc1c(CNC2CC2)ccnc1OCCCO[Si](C)(C)C(C)(C)C,,Cc1ccccc1,,[H-].[Na+],,val
US20050187390A1,CC(=O)c1cc(C(=O)N2CCCC2)ccc1-c1ccc(Cl)cc1.COC(=O)c1ccc(N)c(C=O)c1>>O=C(O)c1ccc2nc(-c3cc(C(=O)N4CCCC4)ccc3-c3ccc(Cl)cc3)ccc2c1,,C1COCCO1,CCO,Cl,[K+].[OH-],val
US20150197512A1,CCCCc1ccc2[nH]c(C=O)cc2c1.CI>>CCCCc1ccc2c(c1)cc(C=O)n2C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020049236A1,C=CCOC(=O)NC(Cc1cc(C2CCCN2C(=O)Cc2ccc(N)cc2)no1)C(=O)OCC.O=C(Cl)c1c(Cl)cccc1Cl>>C=CCOC(=O)NC(Cc1cc(C2CCCN2C(=O)Cc2ccc(NC(=O)c3c(Cl)cccc3Cl)cc2)no1)C(=O)OCC,,CCOC(C)=O,,ClCCl,c1ccncc1,val
US20040067318A1,CC(C)(C)C(=O)CC(=O)C(C)(C)C.NN>>CC(C)(C)c1cc(C(C)(C)C)[nH]n1,,ClCCl,,O,,val
US20110021538A1,CCOC(=O)c1cc[nH]n1.O=C1CCC(=O)N1Cl>>CCOC(=O)c1n[nH]cc1Cl,,CN(C)C=O,,,,val
US20110152496A1,CC1=CCC(C(C)(C)OC(=O)COC=O)CC1OC(=O)COC=O>>CC1=CCC(C(C)(C)OC(=O)CO)CC1OC(=O)CO,,O=C([O-])O,[Na+],,,val
US05284971,COC(=O)Cc1cc(Br)c(S(=O)(=O)c2ccc(O)c(C(C)C)c2)c(Br)c1>>CC(C)c1cc(S(=O)(=O)c2c(Br)cc(CC(=O)O)cc2Br)ccc1O,,[Na+],[OH-],,,val
US20100029650A1,CC(C)OB(OC(C)C)OC(C)C.CC(C)c1noc(N2CCC(COc3ccc(Br)cc3)CC2)n1>>CC(C)c1noc(N2CCC(COc3ccc(B(O)O)cc3)CC2)n1,,C1CCOC1,,Cl,[Li]CCCC,val
US20040147588A1,CCOc1cc(C(CC(O)CC)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC>>CCOc1cc(C(CC(=O)CC)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20110034469A1,CCO[C@@H]1C[C@@H]2CN(C(=O)[C@@H](NC(=O)[C@H](CC)N(C)C(=O)OC(C)(C)C)C3CCC(F)(F)CC3)[C@H](C(=O)N[C@@H]3CCOc4ccccc43)CN2C1>>CCO[C@@H]1C[C@@H]2CN(C(=O)[C@@H](NC(=O)[C@H](CC)NC)C3CCC(F)(F)CC3)[C@H](C(=O)N[C@@H]3CCOc4ccccc43)CN2C1,,O=C(O)C(F)(F)F,,,,val
US05741797,COc1ccc(C(C)C)cc1CN[C@H]1[C@H]2CCN(C[C@@H]2C(=O)O)[C@H]1C(c1ccccc1)c1ccccc1.Cl.Cl>>Cl.Cl.N[C@H]1[C@H]2CCN(C[C@@H]2C(=O)O)[C@H]1C(c1ccccc1)c1ccccc1,[Pd],O,,,,val
US20090069341A1,CCc1cc([N+](=O)[O-])c(OC)cc1OC>>CCc1cc(N)c(OC)cc1OC,,CCO,,,,val
US20090264428A1,CCOC(=O)[C@@H]1C[C@H]1COS(C)(=O)=O.CN>>CCOC(=O)[C@@H]1C[C@H]1CNC,,CC#N,CCO,,,val
US20160264552A1,CC(C)(C)OC(=O)NC1CCNCC1.O=[N+]([O-])c1ccc(CBr)cc1>>CC(C)(C)OC(=O)NC1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20090275588A1,CCN.Cn1cc(C=O)cn1>>CCNCc1cnn(C)c1,,C1CCOC1,,,,val
US20040048847A1,C#Cc1ccccc1.O=Cc1ccc(Br)cc1>>O=Cc1ccc(C#Cc2ccccc2)cc1,,CCN(CC)CC,,,,val
US04957928,Cc1ccc(S(=O)(=O)Cl)cc1.OCCC1COc2ccccc2O1>>Cc1ccc(S(=O)(=O)OCCC2COc3ccccc3O2)cc1,,c1ccncc1,,,,val
US20050267095A1,CN(C)CC1(c2ccc(O)cc2)CCOCC1.OCCC1CCN(CCCCl)CC1>>CN(C)CC1(c2ccc(OCCCN3CCC(CCO)CC3)cc2)CCOCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080275067A1,Cc1cccc2nc(C(C)Oc3ncnc4c3ncn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12>>Cc1cccc2nc(C(C)Oc3ncnc4[nH]cnc34)n(-c3ccccc3)c(=O)c12,,CO,Cl,,,val
US20040067966A1,CCCn1c(=O)c2c(ncn2CN2CCCC2)n(CCC)c1=O.O=C1CCCC(=O)CCC1>>CCCn1c(=O)c2[nH]c(C34CCCC(O)(CCC3)O4)nc2n(CCC)c1=O,,C1CCOC1,,[Li]CCCC,,val
US06300501B1,Cc1cnnc2ccccc12>>CC(CN)c1ccccc1N,[Ni],CO,,,,val
US20110015119A1,CN(C)C=O.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.COC(=O)c1ccc(OCCBr)cc1.O>>COC(=O)c1ccc(OCCN2CCOCC2)cc1,,CN(C)C=O,,,,val
US05206053,C=COCCOc1ccc(CO[Si](C)(C)C)cc1.O=C1C=CC(=O)O1>>C=COCCOc1ccc(CO[Si](C)(C)C)cc1.O=C1C=CC(=O)O1,,ClCCCl,,,,val
US04863958,C1N2CN3CN1CN(C2)C3.CCCc1cc(Cl)c(O)cc1O.O=C(O)C(F)(F)F>>CCCc1cc(Cl)c(O)c(C=O)c1O,,O=C(O)C(F)(F)F,,O,,val
US20130150343A1,CC(C)(C)OC(=O)N1CCC(Cc2nnc3ccc(O[C@@H]4CC[C@H](N)c5ccccc54)cn23)CC1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(CC5CCN(C(=O)OC(C)(C)C)CC5)n4c3)c3ccccc32)cc1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CO,val
US20120171199A1,CC(=O)c1nc2c(N3CCOCC3)nc(Cl)nc2n1C1CCCCO1>>CC(O)c1nc2c(N3CCOCC3)nc(Cl)nc2n1C1CCCCO1,,C1CCOC1,CCO,[BH4-].[Na+],,val
US05312616,O=C(Cl)C(=O)Cl.O=C(O)c1cc(I)cc(I)c1I>>O=C(Cl)c1cc(I)cc(I)c1I,CN(C)C=O,Cc1ccccc1,ClCCl,,,val
US20160264567A1,CCOC(=O)c1cn(-c2cnc(C(F)(F)F)nc2)nc1OC>>COc1nn(-c2cnc(C(F)(F)F)nc2)cc1CO,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20090023919A1,CN=C=O.NC(=O)c1ncc(N)[nH]1.[N-]=[N+]=C1NCN=C1C(N)=O>>Cn1nnc2c(C(N)=O)ncn2c1=O,,ClCCl,,,,val
US20080132507A1,CCOC(=O)C(=O)C(F)(F)F.Cc1cccc(C)c1O>>CCOC(=O)C(O)(c1cc(C)c(O)c(C)c1)C(F)(F)F,CCN(CC)CC,ClC(Cl)(Cl)Cl,,,,val
US05310723,C#CCBr.Cn1c(C(F)(F)F)cc(=O)n(-c2cc3[nH]c(=O)ccc3cc2F)c1=O>>C#CCn1c(=O)ccc2cc(F)c(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)cc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150376130A1,COC(=O)c1cccnc1F.COc1cc(N)ccc1Cl>>COc1ccc(Cl)c(Nc2ncccc2C(=O)O)c1,,ClCCl,,CCN(CC)CC,Cl,val
US20080146607A1,CB1OB(C)OB(C)O1.CCCC1(C(=O)c2cc(Cl)c(Cl)s2)CCN(C(=O)OC(C)(C)C)C1>>CCCC1(C(=O)c2cc(Cl)c(C)s2)CCN(C(=O)OC(C)(C)C)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20080125425A1,CCCn1c(=O)c2[nH]c(-c3ccc(NCCN(C)C)nc3)cc2n(CCC)c1=O.O=C=Nc1ccc(F)cc1>>CCCn1c(=O)c2[nH]c(-c3ccc(N(CCN(C)C)C(=O)Nc4ccc(F)cc4)nc3)cc2n(CCC)c1=O,,C1CCOC1,,,,val
US20100216860A1,COc1cccc2c1c(N(S(=O)(=O)c1ccc(Cl)s1)S(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(OCCN(C)C)cc1>>COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(OCCN(C)C)cc1,,CO,,[Na+].[OH-],,val
US20160222014A1,C[C@H]1CN(c2ccc(Nc3ncc4ccn(Cc5cccnc5N(C)S(C)(=O)=O)c4n3)cc2)CCN1.C[C@H]1CO1>>C[C@H](O)CN1CCN(c2ccc(Nc3ncc4ccn(Cc5cccnc5N(C)S(C)(=O)=O)c4n3)cc2)C[C@@H]1C,,CO,,,,val
US04845100,CC(C)=CCC/C(C)=C/CN1CCNCC1.CCOP(=O)(Cl)OCC.O=C1CCc2cc(C(=O)O)ccc2N1>>CC(C)=CCC/C(C)=C/CN1CCN(C(=O)c2cccc3c2CCC(=O)N3)CC1.Cl,,C1CCOC1,CCN(CC)CC,O=C([O-])O.[Na+],,val
US20030166644A1,CC(C)(C)CNC(=O)c1ccc(O)nc1.CN(C(=O)Cl)c1ccccc1>>CN(C(=O)Oc1ccc(C(=O)NCC(C)(C)C)cn1)c1ccccc1,,C1CCOC1,,C1CN2CCN1CC2,,val
US20090170908A1,CC[Si](CC)(CC)OC1C(C(=O)OC)CCC12CCCCC2>>COC(=O)C1CCC2(CCCCC2)C1O,,C1CCOC1,,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20060194842A1,CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(C(=O)O)CCC3)CC2)c2ccccc21.Cl>>CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(C(=O)O)CCC3)CC2)c2ccccc21.Cl,,C1CCOC1,,,,val
US20110195948A1,Nc1cnn2ccc(N3CCC[C@@H]3c3cccc(F)c3)nc12.O=C(n1ccnc1)n1ccnc1.OC1CNC1>>O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cccc(F)c3)nc12)N1CC(O)C1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US06121264,NCCCCO.O=[N+]([O-])c1cc(C(F)(F)F)c(F)cc1F>>O=[N+]([O-])c1cc(C(F)(F)F)c(F)cc1NCCCCO,,CCO,,,,val
US20140148454A1,C=C(C)c1cc(N2CCOCC2)cnc1C#N>>CC(C)c1cc(N2CCOCC2)cnc1C#N,[Pd],CCO,,,,val
US20140323418A1,CC(=O)Oc1cnn(-c2cccc([N+](=O)[O-])c2)n1.NC(=O)c1cnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc(-n2ncc[n+]2[O-])c1>>NC(=O)c1cnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc(-n2ncc(O)n2)c1,[Pd],CCOC(C)=O,,[H][H],,val
US20090221551A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCCNc1c([N+](=O)[O-])cnc2cc(Br)ccc12>>CC(C)(C)OC(=O)NCCCNc1c([N+](=O)[O-])cnc2cc(Br)ccc12,,CCN(CC)CC,CN(C)C=O,O,,val
US20140323435A1,Cc1sc2c(NC[C@@H](N)Cc3ccccc3)nc(-c3ccncc3)nc2c1Br.c1cn[nH]c1>>N[C@H](CNc1nc(-c2ccncc2)nc2c(-n3cccn3)csc12)Cc1ccccc1,I[Cu]I,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04112095,CC(=O)NN.Fc1ccc(-c2ccc(Cl)nn2)cc1C(F)(F)F>>Cc1nnc2ccc(-c3ccc(F)c(C(F)(F)F)c3)nn12,,CCCCO,,,,val
US06054586,ClP(Cl)(Cl)(Cl)Cl.O=C(c1ccccc1)N1CCC(CO)CC1>>O=C(c1ccccc1)N1CCC(CCl)CC1,,ClC(Cl)Cl,,O,,val
US20150366977A1,Brc1ccc2c(c1)CCN2.CC(=O)Cl>>CC(=O)N1CCc2cc(Br)ccc21,,CC(=O)O,,,,val
US20160206748A1,CC1(COCC(=O)O)CC(O)C(O)C1.COC(C)(C)OC>>CC1(COCC(=O)O)CC2OC(C)(C)OC2C1,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20130023526A1,CCOC(=O)CC#N.COc1cc(CNC(=O)c2cc(C3=NOC(C4CCNCC4)C3)nc(C)n2)ccc1F>>COc1cc(CNC(=O)c2cc(C3=NOC(C4CCN(C(=O)CC#N)CC4)C3)nc(C)n2)ccc1F,,O,,CCN(CC)CC,Cl,val
US20030069294A1,COC(=S)C(C)Cc1ccc(OCc2nc3ccc(SC)cc3n2C)cc1.Cl>>CSc1ccc2nc(COc3ccc(CC(C)C(O)=S)cc3)n(C)c2c1.Cl,,C1COCCO1,,Cl,,val
US20100075998A1,CC(C)(C)OC(=O)NC[C@H](Cc1ccccc1)NC(=O)c1cn(CC(F)(F)F)c2c1CCc1cnccc1-2>>NC[C@H](Cc1ccccc1)NC(=O)c1cn(CC(F)(F)F)c2c1CCc1cnccc1-2,,C1COCCO1,,CCOCC,Cl,val
US20150299192A1,C#Cc1cnc(NC(C)=O)nc1-c1cc2c(n1C)CCN(C(=O)OC(C)(C)C)C2=O.CI>>C#Cc1cnc(N(C)C(C)=O)nc1-c1cc2c(n1C)CCN(C(=O)OC(C)(C)C)C2=O,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US06699879B1,COC(=O)c1cc(F)nc2ccccc12>>O=C(O)c1cc(F)nc2ccccc12,,ClCCl,,BrB(Br)Br,,val
US20110311461A1,Nc1ccccc1.O=CC(=O)O.OB(O)c1ccc(OCc2ccccc2)nc1>>O=C(O)C(Nc1ccccc1)c1ccc(OCc2ccccc2)nc1,,CC#N,,O,,val
US20050070592A1,COC(=O)CBr.Oc1ccc(-c2ccc3c(c2)c2c(n3Cc3ccccc3)CCCC2)cc1>>COC(=O)COc1ccc(-c2ccc3c(c2)c2c(n3Cc3ccccc3)CCCC2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130245254A1,CC(C)=O.Cc1cc(Br)ncc1Br>>Cc1cc(C(C)(C)O)ncc1Br,,Cc1ccccc1,,[Li]CCCC,,val
US06545008B1,Cc1nc(Cl)nc(N2CCc3cc(F)ccc3C2C)c1C.Nc1ccc(F)cc1>>Cc1nc(Nc2ccc(F)cc2)nc(N2CCc3cc(F)ccc3C2C)c1C.Cl,,CN(C)C=O,,,,val
US20130023526A1,CC(=O)O[C@@H](C)C(=O)Cl.COc1cc(CNC(=O)c2cc(C3=NO[C@H]([C@H]4CO[C@H](CN)CO4)C3)nc(C)n2)ccc1F>>COc1cc(CNC(=O)c2cc(C3=NO[C@H]([C@H]4CO[C@H](CNC(=O)[C@H](C)OC(C)=O)CO4)C3)nc(C)n2)ccc1F,,ClCCl,,,,val
US20130109661A1,CC1CCCN1c1cccc(Nc2cc(-c3ccc(O)cc3)nn3ccnc23)n1.CS(=O)(=O)OCCN1CCCCC1>>CC1CCCN1c1cccc(Nc2cc(-c3ccc(OCCN4CCCCC4)cc3)nn3ccnc23)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110118236A1,CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c2c1CCCC2>>CCCCc1nn(Cc2ccc(C(=O)O)cc2)c2c1CCCC2,,O,,CO,[Li+].[OH-],val
US20160271130A1,CSc1cc(C)nc(N2CCN(C(=O)OC(C)(C)C)CC2)n1>>CSc1cc(C)nc(N2CCNCC2)n1,,C1COCCO1,ClCCl,Cl,,val
US20070298346A1,C=Cc1ccc(CCl)cc1.CCCCCCCCCCCCCCCCCCN(C)C>>C=Cc1ccc(C[N+](C)(C)CCCCCCCCCCCCCCCCCC)cc1.[Cl-],,CC(C)=O,,,,val
US05059608,BrCc1ccccc1.c1ccc(C2=NCCc3ccccc32)cc1>>[Br-].c1ccc(C[N+]2=C(c3ccccc3)c3ccccc3CC2)cc1,,CC#N,,,,val
US20100105604A1,C=C(C)CBr.CCOC(=O)c1ccc(O)cc1>>C=C(C)COc1ccc(C(=O)O)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160193216A1,CS(=O)(=O)Cl.OC[C@H]1CCc2sc3ncnc(NC4CCC(N5CCOCC5)CC4)c3c21>>CS(=O)(=O)OC[C@H]1CCc2sc3ncnc(NC4CCC(N5CCOCC5)CC4)c3c21,,ClCCl,ClCCl,CCN(CC)CC,,val
US20140142082A1,Cn1c(CC2CCCCC2)ccc1S(N)(=O)=O.O=C1CCC(=O)N1Br>>Cn1c(S(N)(=O)=O)cc(Br)c1CC1CCCCC1,,C1CCOC1,,O,,val
US06046213,Cc1cc(C(=O)C(C)N2CCC(O)(c3ccc(F)cc3)CC2)ccc1O[Si](C(C)C)(C(C)C)C(C)C>>Cc1cc([C@@H](O)[C@@H](C)N2CCC(O)(c3ccc(F)cc3)CC2)ccc1O[Si](C(C)C)(C(C)C)C(C)C,,CCO,,[BH4-].[Na+],,val
US05719141,COC1=N[C@H](C(C)C)C(OC)=N[C@H]1C[C@H](C)CCO[Si](C(C)C)(C(C)C)C(C)C>>COC(=O)[C@@H](N)C[C@H](C)CCO[Si](C(C)C)(C(C)C)C(C)C,,C1CCOC1,,Cl,[Na+].[OH-],val
US20130109789A1,CI.COCC(CO)(COC(C)(C)C)C(C)(C)C>>COCC(COC)(COC(C)(C)C)C(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20130137679A1,COc1ccc2c(c1)/C(=N/O)CC2.CS(=O)(=O)Cl>>COc1ccc2c(c1)/C(=N/OS(C)(=O)=O)CC2,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20150141700A1,CC(C)c1ccccc1C(C)C>>CC(C)c1ccccc1,,c1ccccc1,,,,val
US20110028501A1,COC(OC)OC.NC(=NO)c1ccc(O)cc1>>Oc1ccc(-c2ncon2)cc1,,CCO,,,,val
US20040052822A1,CI.Cc1cccc(C)c1O>>COc1c(C)cccc1C,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05736548,CCCOc1ccccc1C=O.Cc1nn(C2CCCC2)c(N)c1C(N)=O>>CCCOc1ccccc1-c1nc2n(C3CCCC3)[nH]c(C)c-2c(=O)n1,,O,,CS(=O)(=O)O,,val
US20120263670A1,CC(=O)Nc1ccc(C(=O)CN(C)Cc2ccc(Cl)cc2Cl)cc1>>CC(=O)Nc1ccc(C(O)CN(C)Cc2ccc(Cl)cc2Cl)cc1,,CO,,[BH4-].[Na+],,val
US20100120714A1,COC(=O)NCc1cc(-c2cc[nH]n2)ccc1Cl.FC(F)(F)Oc1cccc(CBr)c1>>COC(=O)NCc1cc(-c2ccn(Cc3cccc(OC(F)(F)F)c3)n2)ccc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100286145A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cc(O)cc(C(C)(C)Cl)c1>>C=C(C)c1cc(O)cc(CNC[C@@H](O)[C@@H](N)Cc2ccccc2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140283218A1,CON(C)C(=O)c1cnc(-c2cccnc2)s1.C[Mg]Br>>CC(=O)c1cnc(-c2cccnc2)s1,,C1CCOC1,CCOCC,O,,val
US04305944,CC1CNCCN1CCCCN1C(=O)CC2(CCCC2)CC1=O.N#Cc1cccnc1Cl>>CC1CN(c2ncccc2C#N)CCN1CCCCN1C(=O)CC2(CCCC2)CC1=O.Cl,,CCO,,CCN(CC)CC,,val
US06875884B1,NS(=O)(=O)c1ccccc1.O=C(O)CCCN(CCCNC(=O)Nc1ccc(Br)cc1)C1CCCc2ccccc21>>O=C(CCCN(CCCNC(=O)Nc1ccc(Br)cc1)C1CCCc2ccccc21)NS(=O)(=O)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US04002647,COC(C)(C)CCCC(C)CC(C)OS(=O)(=O)c1ccc(C)cc1.Oc1ccc2c(c1)OCC2>>COC(C)(C)CCCC(C)CC(C)Oc1ccc2c(c1)OCC2,,CN(C)P(=O)(N(C)C)N(C)C,,C1CCOC1,[H-].[Na+],val
US06162610,COc1ccc(OC)cc1.O=C(Cl)c1ccccc1F>>O=C(c1ccccc1)c1ccccc1,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100249124A1,CC(c1ccc(O)cc1Cl)C(O)(c1ccc2oc(=O)n(C)c2c1)C(F)(F)F.CCOC(=O)C(C)(C)Br>>CCOC(=O)C(C)(C)Oc1ccc(C(C)C(O)(c2ccc3oc(=O)n(C)c3c2)C(F)(F)F)c(Cl)c1,,CC(=O)N(C)C,O,Cl,[Na+].[OH-],val
US20140037564A1,COc1cc(C=O)cc(OC)c1O.Nc1cc(Cl)ccc1S>>COc1cc(-c2nc3cc(Cl)ccc3s2)cc(OC)c1O,,CN(C)C=O,,,,val
US20150099730A1,O=C(Cl)C1CC1.O=C1N(C[C@@H]2CCNC2)C(c2ccc(Br)cc2)=NC12CCCC2>>O=C(C1CC1)N1CC[C@@H](CN2C(=O)C3(CCCC3)N=C2c2ccc(Br)cc2)C1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20130289016A1,CC(C)(C)OC(=O)N1CCC(NCCCO)CC1.FC(F)c1nc2ccccc2n1-c1nc(Cl)nc(N2CCOCC2)n1>>CC(C)(C)OC(=O)N1CCC(N(CCCO)c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1,,CCN(C(C)C)C(C)C,CN(C)C=O,,,val
US20050215577A1,CI.COC(=O)C(C1CCC(=O)C1)S(=O)(=O)c1ccccc1>>COC(=O)C(C)(C1CCC(=O)C1)S(=O)(=O)c1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US20100204196A1,CCN(C)CC(=O)N1CCCc2cc(OC)c([N+](=O)[O-])cc21>>CCN(C)CC(=O)N1CCCc2cc(OC)c(N)cc21,[Pd],CO,,,,val
US20110039892A1,C[C@@H](N)c1ccc(F)cc1F.N#CC(C(N)=O)C1OC(=O)C(Cl)=C1Cl>>C[C@H](c1ccc(F)cc1F)n1cc(Cl)cc(C(N)=O)c1=N.Cl,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US05344843,O=C(Cl)CBr.c1ccc2c(c1)CCNC2>>O=C(CBr)N1CCc2ccccc2C1,,ClCCl,,O,,val
US20010025041A1,CC(C)(C)OC(=O)N1CCC(COc2cccc(COc3ccccc3Cl)c2)CC1.Cl>>Cl.Clc1ccccc1OCc1cccc(OCC2CCNCC2)c1,,C1COCCO1,ClCCl,,,val
US20090203647A1,Nc1nc(Cl)ncc1F.OCc1ccc(F)cc1>>Nc1nc(OCc2ccc(F)cc2)ncc1F,,C1COCCO1,,[H-].[Na+],,val
US20140228359A1,CC(C)(C)OC(=O)NCC(N)c1c[nH]c2ccc(Br)cc12.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)NCC(NC(=O)C(F)(F)F)c1c[nH]c2ccc(Br)cc12,,ClCCl,,CCN(CC)CC,,val
US20050256311A1,CC(C)=O.COCCN(C(C)(C)C)S(=O)(=O)c1ccc(Nc2nccc(-c3cnc(C)n3CC3CC3)n2)cc1>>COCCN(C(C)(C)C)S(=O)(=O)c1ccc(Nc2nccc(-c3cnc(CC(C)(C)O)n3CC3CC3)n2)cc1,,C1CCOC1,,O,[Li]CCCC,val
US20090143353A1,CCOC(=O)c1nc2c(C#N)c(C)c(-c3ccccc3)c(F)c2o1.CNCCc1ccccc1>>Cc1c(-c2ccccc2)c(F)c2oc(C(=O)N(C)CCc3ccccc3)nc2c1C#N,,ClCCl,,C[Al](C)C,Cl,val
US04105772,C1CCNC1.C=O.Cn1cc(C=CC(N)=O)c([N+](=O)[O-])n1>>Cn1cc(C=CC(=O)NCN2CCCC2)c([N+](=O)[O-])n1,,CO,,,,val
US20070149514A1,CCOC(=O)COc1ccc(S(=O)(=O)n2cc(-c3nccs3)c3cc(Br)ccc32)cc1C.OB(O)c1ccc(C(F)(F)F)cc1>>Cc1cc(S(=O)(=O)n2cc(-c3nccs3)c3cc(-c4ccc(C(F)(F)F)cc4)ccc32)ccc1OCC(=O)O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20120196864A1,CN1CCCC1CCN.COc1cc(C=O)ccc1Oc1ccc(C#N)cc1C(F)(F)F.O=C1NC(=S)CS1>>COc1cc(/C=C2\SC(=O)N=C2NCCC2CCCN2C)ccc1Oc1ccc(C#N)cc1C(F)(F)F,,CCO,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20050038068A1,CC1(C)OB(c2cc[nH]n2)OC1(C)C.N#Cc1c(O)c2c(-c3ccc(I)cc3)csc2[nH]c1=O>>N#Cc1c(O)c2c(-c3ccc(-c4cc[nH]n4)cc3)csc2[nH]c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04529698,CCCC[N+](CCCC)(CCCC)CCCC.O=C(N[C@H]1CN(S(=O)(=O)[O-])C1=O)OCc1ccccc1>>CCCC[N+](CCCC)(CCCC)CCCC.N[C@H]1CN(S(=O)(=O)[O-])C1=O,[Pd],CN(C)C=O,,,,val
US20110183938A1,BrBr.CCN(C(=O)OC(C)(C)C)[C@H]1CCN(c2ccnc3c2c2cc(C#N)ncc2n3COCC[Si](C)(C)C)C1>>CCN(C(=O)OC(C)(C)C)[C@H]1CCN(c2c(Br)cnc3c2c2cc(C#N)ncc2n3COCC[Si](C)(C)C)C1,,CC(=O)O,CCOC(C)=O,CC(=O)[O-].[Na+],,val
US06232290B1,CCOC(=O)c1ccc(-c2cn3nc(-c4ccc(OC)cc4)sc3n2)cc1>>O=C(O)c1ccc(-c2cn3nc(-c4ccc(O)cc4)sc3n2)cc1,,ClCCl,,O,O=C(O)C(F)(F)F,val
US20080004300A1,CC1(C)CNc2cc(N3C(=O)N(Cc4ccnc5ccccc45)C(C)(C)C3=O)ccc21.CN1CCNCC1.O=C(Cl)CCl>>CN1CCN(CC(=O)N2CC(C)(C)c3ccc(N4C(=O)N(Cc5ccnc6ccccc56)C(C)(C)C4=O)cc32)CC1,,ClCCCl,,CCN(C(C)C)C(C)C,,val
US20160068496A1,C1COCCN1.COc1cc2nc(Cl)nc(Cl)c2cc1Br>>COC1=CC2=NC(Cl)=NC(N3CCOCC3)C2C=C1Br,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US20160145247A1,CC(C)(C)O.O=C(O)Cc1c(Br)cccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)Cc1c(Br)cccc1[N+](=O)[O-],CN(C)c1ccncc1,CC(C)(C)O,,,,val
US05639776,CC(C)(C)OC(=O)CBr.O=C1CC(c2ccc(Cl)cc2)=NN1>>CC1C(=O)N(C(=O)OC(C)(C)C)N=C1c1ccc(Cl)cc1,,CN(C)C=O,O,CCOCC,[H-].[Na+],val
US20140249131A1,C=CC(=O)Cl.COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2ccc(=O)n(-c3cccc(N)c3)c2n1>>C=CC(=O)Nc1cccc(-n2c(=O)ccc3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20100099077A1,CO.COC(=O)c1cc(C)c(OC(C)=O)c(CBr)c1>>COCc1cc(C(=O)OC)cc(C)c1O,,CO,,O=C([O-])O.[Na+],,val
US05192765,CC(C)(N)CO.O=C(O)C(F)(F)F.OC(c1ccccc1)c1ccccc1>>CC(C)(N)COC(c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20070004736A1,Cc1ncc2n1C(=O)N(C1CCN(Cc3ccccc3)CC1)C2>>Cc1ncc2n1C(=O)N(C1CCNCC1)C2,[Pd],CO,,,,val
US20090069365A1,O=C(Cl)C1CN(Cc2ccccc2)CC1c1cc(Br)cs1>>O=C1c2c(Br)csc2C2CN(Cc3ccccc3)CC12,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20060094767A1,BrCCOC1CCCCO1.FC(F)(F)c1ccc(OC2CCNCC2)cc1>>FC(F)(F)c1ccc(OC2CCN(CCOC3CCCCO3)CC2)cc1,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20150076072A1,ClCC1CO1.NCCNCCNCCNCCN>>ClCC1CO1.NCCNCCNCCNCCN,,O,,,,val
US05445762,C1COCCOCCOCCN1.CC(C)(C)C(=O)Cl>>CC(C)(C)C(=O)N1CCOCCOCCOCC1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20020049210A1,O=C(C=CC1CCN(Cc2ccccc2)CC1)c1nc2ccccc2s1>>O=C(CCC1CCN(Cc2ccccc2)CC1)c1nc2ccccc2s1,O=[Pt]=O,CCO,CCOC(C)=O,,,val
US20100239576A1,O=C(OC1(COC2CCCCO2)CC1)c1ccccc1>>O=C(OC1(CO)CC1)c1ccccc1,,CO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20020065418A1,CCCC[Sn](CCCC)(CCCC)N=[N+]=[N-].CCOC(=O)[C@H](Cc1ccc(C#N)cc1)NC(=O)c1ccc2c(c1)nc(-c1ccoc1)n2C1CCCCC1>>CCOC(=O)[C@H](Cc1ccc(-c2nnn[nH]2)cc1)NC(=O)c1ccc2c(c1)nc(-c1ccoc1)n2C1CCCCC1,,CS(C)=O,,O=C(O)C(F)(F)F,,val
US20130178494A1,CNC.O=C(CCCl)Nc1cccc([N+](=O)[O-])c1>>CN(C)CCC(=O)Nc1cccc([N+](=O)[O-])c1,,C1CCOC1,,,,val
US20110263562A1,CN1CCOCC1.O=[N+]([O-])c1cc(OCC2CC2)ccc1CBr>>O=Cc1ccc(OCC2CC2)cc1[N+](=O)[O-],,CC#N,,,,val
US07109225B2,Cc1oc(C(C)(C)C)nc1CCl.O=Cc1ccc(O)c2ccsc12>>Cc1oc(C(C)(C)C)nc1COc1ccc(C=O)c2sccc12,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120022069A1,CCOC(=O)/C=C/C1CCN(C(=O)OC(C)(C)C)CC1.Cl>>CCOC(=O)/C=C/C1CCNCC1.Cl,,C1COCCO1,,,,val
US20110015240A1,CC(=O)Nc1nc(CCc2ccc(CNC(=O)NNC(=O)OC(C)(C)C)cc2)cs1.Cl>>CC(=O)Nc1nc(CCc2ccc(CNC(=O)NN)cc2)cs1.Cl,,ClCCl,,C1COCCO1,,val
US20120214803A1,FC(F)(F)c1ccc(Br)cn1.O=Cc1ccc2cccnc2c1[N+](=O)[O-]>>O=[N+]([O-])c1c(C(O)c2ccc(C(F)(F)F)nc2)ccc2cccnc12,,C1CCOC1,,[Li]CCCC,,val
US20130158019A1,CC1CCC(C(=O)O)CN1.CCO>>CCOC(=O)C1CCC(C)NC1,,O,,Cl,[Na+].[OH-],val
US20150368210A1,CC(C)(C)OC(=O)N1CCC(NCc2ccc(-c3cnc(N)c(NCc4c(Cl)cccc4Cl)n3)cc2)C[C@@H]1C(=O)OC1CCCC1.CC=O>>CCN(Cc1ccc(-c2cnc(N)c(NCc3c(Cl)cccc3Cl)n2)cc1)C1CCN(C(=O)OC(C)(C)C)[C@@H](C(=O)OC2CCCC2)C1,,CC#N,,CC(=O)O,,val
US20050124638A1,C=C(C#N)CO.CNC>>CN(C)CC(C#N)CO,,C1CCOC1,,,,val
US04904696,O=[N+]([O-])c1ccc(OC(F)(F)C(F)F)cc1F>>Nc1ccc(OC(F)(F)C(F)F)cc1F,O=[Pt]=O,CCOC(C)=O,,[H][H],,val
US04490533,CN(C)Cc1cccc(Cl)n1.NCCS>>CN(C)Cc1cccc(SCCN)n1,,CCO,CN(C)C=O,Cl,[H-].[Na+],val
US20090093518A1,CC(C)Br.Cc1c[nH]c(=O)c2cc(F)c(OC3CCNCC3)cc12>>Cc1c[nH]c(=O)c2cc(F)c(OC3CCN(C(C)C)CC3)cc12,,CN(C)C=O,,CCN(CC)CC,,val
US20150313864A1,CCOC(=O)CNC.CN(C)C(=O)/C=C1\OC(C)(C)OC1=O>>CCOC(=O)CN(C)C(=O)C(=O)CC(=O)N(C)C,,ClCCl,,CCN(CC)CC,Cl,val
US20040116424A1,CCCCC(C(=O)c1ccccc1)C(C(=O)OC)C(=O)OC>>CCCCC(CC(=O)OC)C(=O)c1ccccc1,,CS(C)=O,,O,[Cl-].[Na+],val
US20050130954A1,O=P(Cl)(Cl)Cl.[O-][n+]1cccc2occc21>>Clc1ccnc2ccoc12,,ClC(Cl)Cl,,,,val
US20040209929A1,Cc1ccc(S(=O)(=O)OS(=O)(=O)c2ccc(C)cc2)cc1.Cc1oc(-c2ccccc2)nc1CCO>>Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccccc3)oc2C)cc1,,c1ccncc1,,,,val
US04870089,CON(C)C(=O)C(F)(F)F.FC1(F)Oc2ccc(Br)cc2C1(F)F>>O=C(c1ccc2c(c1)C(F)(F)C(F)(F)O2)C(F)(F)F,,CCOCC,,[Mg],,val
US20110263564A1,C[Si](C)(C)C#N.FC(F)(F)c1cccc(-c2ccc3c(n2)C(Br)CCO3)c1>>N#CC1CCOc2ccc(-c3cccc(C(F)(F)F)c3)nc21,,CC#N,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05382600,CI.CO.Cc1ccc2c(c1)OC(=O)CC2c1ccccc1>>COC(=O)CC(c1ccccc1)c1ccc(C)cc1OC,,CC(C)=O,CO,O=C([O-])[O-].[K+].[K+],,val
US20130331374A1,C1NCC12COC2.N#Cc1cc([N+](=O)[O-])ccc1F>>N#Cc1cc([N+](=O)[O-])ccc1N1CC2(COC2)C1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100152155A1,CC(C)COC(C)ONC(=O)c1cnc(N2CC3C(C2)C3NCc2ccc3ccccc3c2)nc1.CCN(CC)CC.CN(C)C=O>>CCN(CC)CCC(=O)N(Cc1ccc2ccccc2c1)C1C2CN(c3ncc(C(=O)NOC(C)OCC(C)C)cn3)CC21,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20020160997A1,C[C@@H](Cc1c2n(c3ccc(OC4CC4)cc13)CCC2)NC(=O)OC(C)(C)C.Cl>>C[C@H](N)Cc1c2n(c3ccc(OC4CC4)cc13)CCC2.Cl,,CCOC(C)=O,,,,val
US20050182052A1,BrCc1ccccc1.OC[C@H]1CNC[C@@H]1O>>OC[C@H]1CN(Cc2ccccc2)C[C@@H]1O,,CCO,,CCN(CC)CC,,val
US05670514,CC(C)(C)C(=O)Cl.CN1C(=O)CC[C@]2(C)c3ccc(-c4cccc(N)c4)cc3CC[C@@H]12>>Cc1cc(-c2cccc(NC(=O)C(C)(C)C)c2)cc2c1[C@H]1CCC(=O)N(C)[C@@H]1CC2,,ClC(Cl)Cl,,ClCCl,c1ccncc1,val
US05646188,ON=C1CC(=NO)c2ccccc21>>NC1CC(N)c2ccccc21,,CCO,,O,[Na],val
US20050261333A1,Clc1cnc2[nH]c(-c3ccc(OCCN4CCOCC4)cc3)nc2c1Cl.NC1CCNC1>>NC1CCN(c2c(Cl)cnc3nc(-c4ccc(OCCN5CCOCC5)cc4)[nH]c23)C1,,CCOC(C)=O,,,,val
US06218376B1,CI.Cc1ccc2c(c1)CCc1nc(C)sc1C2(O)c1c[nH]c(=O)[nH]c1=O>>Cc1ccc2c(c1)CCc1nc(C)sc1C2(O)c1cn(C)c(=O)[nH]c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20140018319A1,CC(C)(C)OC(=O)Nc1cc(C#N)cc(N2CCN(C3COC3)C(CF)C2)c1Cl>>N#Cc1cc(N)c(Cl)c(N2CCN(C3COC3)C(CF)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070213331A1,CC(C)(C)OC(=O)N1C[C@H](F)C[C@@H]1CO>>CC(C)(C)OC(=O)N1C[C@H](F)C[C@@H]1C=O,,CCOCC,CS(C)=O,CCN(CC)CC,,val
US20130012719A1,CI.O=C(O)C1CSC(c2ccccc2)=N1>>COC(=O)C1CSC(c2ccccc2)=N1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04749713,COc1ccc(C(O)(c2ccc(OC)cc2)C(c2ccc(C#N)cc2)n2ccnc2)cc1>>COc1ccc(C(=C(c2ccc(C#N)cc2)n2ccnc2)c2ccc(OC)cc2)cc1,,O=S(Cl)Cl,,,,val
US20150010504A1,CC(=O)c1ccc2c(c1)CCc1cc(C(C)=O)sc1-2>>CC(=O)c1ccc2c(ccc3cc(C(C)=O)sc32)c1,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20120202856A1,Cl.Cn1nc(C(C)(C)C)c(Cl)c1-c1nc2cc(-c3ccccc3F)cc(Cl)c2[nH]1>>Cl.Cn1nc(C(C)(C)C)c(Cl)c1-c1nc2cc(-c3ccccc3F)ccc2[nH]1,,CO,ClCCl,,,val
US20040122244A1,C1CCNCC1.COC1=C(OC)C(=O)C(Cc2cccc(C(=O)O)c2OC(C)=O)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2cccc(C(=O)N3CCCCC3)c2OC(C)=O)=C(C)C1=O,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20020193382A1,CC(C)(C)OC(=O)N1CCC(CN2CCNCC2=O)CC1.O=S(=O)(Cl)CCl>>CC(C)(C)OC(=O)N1CCC(CN2CCN(S(=O)(=O)CCl)CC2=O)CC1,,ClCCl,,CCN(CC)CC,,val
US20110306618A1,CS(=O)(=O)NC1CCC(N)CC1.Clc1nccc(-c2cnc3ccccn23)n1>>CS(=O)(=O)NC1CCC(Nc2nccc(-c3cnc4ccccn34)n2)CC1,,CN1CCCC1=O,O,,,val
US20130210803A1,CC(C)=O.Cc1ccc2c(c1)C(c1ccc(F)cc1)CN2N=O>>CC(C)=NN1CC(c2ccc(F)cc2)c2cc(C)ccc21,[Zn],,,[Cl-].[NH4+],,val
US20140162998A1,CC(C)(C)OC(=O)N1CCC(Oc2sncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)CC1>>Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnsc1OC1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120046278A1,Cc1nc(Cl)c2nc(-c3ccc(F)cc3)sc2n1.O=C(COc1ccc(Cl)cc1)N1CCNCC1>>Cc1nc(N2CCN(C(=O)COc3ccc(Cl)cc3)CC2)c2nc(-c3ccc(F)cc3)sc2n1,,C1COCCO1,,CCN(CC)CC,,val
US20090130076A1,CC(C)(C)OC(=O)Nc1nc2c(-c3cccc(C(F)(F)F)c3)cc(C(O)c3ccc(F)cc3)cc2s1>>Nc1nc2c(-c3cccc(C(F)(F)F)c3)cc(Cc3ccc(F)cc3)cc2s1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20090093524A1,CCOC(=O)C#CC(F)(F)F.[N-]=[N+]=Nc1c(Cl)cccc1Cl>>CCOC(=O)c1c(C(F)(F)F)nnn1-c1c(Cl)cccc1Cl,,Cc1ccccc1,,,,val
US20110152235A1,COc1cc(C=O)nc(Cl)n1.Cc1ccc(N2CCNCC2)cc1.O=C1CSC(=O)N1>>COc1cc(/C=C2\SC(=O)NC2=O)nc(N2CCN(c3ccc(C)cc3)CC2)n1,,CCO,,,,val
US20100261771A1,CC(C)(C)OC(=O)/N=C/c1cccc(C(F)(F)F)c1.C[N+](=O)[O-]>>CC(C)(C)OC(=O)NC(C[N+](=O)[O-])c1cccc(C(F)(F)F)c1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US20100273819A1,CONC(=O)C(C)(C)Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)Nc1cc(Cl)ccc12.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CONC(=O)C(C)(C)Oc1ccc(Cl)cc1C1CC(=S)NC(c2cc(F)ccc2C)C12C(=O)Nc1cc(Cl)ccc12,,C1CCOC1,Cc1ccccc1,,,val
US20090270412A1,COc1ccc(C(C)=CBr)cc1.Cc1ccc2[nH]c3c(c2c1)CCN(C)C3>>COc1ccc(C(C)=Cn2c3c(c4cc(C)ccc42)CCN(C)C3)cc1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20090124600A1,COC(=O)C(F)c1ccccc1>>O=C(O)C(F)c1ccccc1,,CO,O,Cl,[K+].[OH-],val
US20120040998A1,C[C@@H]1CC[C@H](c2noc(-c3cc(Cl)c[nH]3)n2)CN1.O=C(O)c1ccnc(Br)c1>>C[C@@H]1CC[C@H](c2noc(-c3cc(Cl)c[nH]3)n2)CN1C(=O)c1ccnc(Br)c1,,CCOC(C)=O,CN(C)C=O,ClCCCl,On1nnc2cccnc21,val
US20120295903A1,Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CC=O)c2cc1C.O=C(O)[C@@H]1CCCN1>>Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCN3CCC[C@H]3C(=O)O)c2cc1C,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20110172297A1,CCOC(=O)C1COCCC1=O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)C1COCC=C1OS(=O)(=O)C(F)(F)F,,C1CCOC1,,[H-].[Na+],,val
US20140045817A1,CC(C)(C)OC(=O)N1CCCC(O)(COc2cc(F)cc3ccc(-c4nnc5ccccn45)nc23)CC1.CI>>COC1(COc2cc(F)cc3ccc(-c4nnc5ccccn45)nc23)CCCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20140120118A1,CC(C)[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N[C@H](C)C(=O)O.CC1(C)OB(c2ccc(N)cc2)OC1(C)C>>CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N[C@@H](C)C(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20090281079A1,CCOC(=O)C(=CN(C)C)C(=O)c1ccc([N+](=O)[O-])cc1.NC(=O)C(N)C(N)=O>>CCOC(=O)c1c[nH]c(C(N)=O)c1-c1ccc([N+](=O)[O-])cc1,,CC(=O)O,,,,val
US20140124896A1,C=CCOCC(O)CO.CN(C)[As](N(C)C)N(C)C>>C=CCOCC1CO[As](N(C)C)O1,,CCCCCC,,,,val
US20150087585A1,Nc1nc(N2CCO[C@@H](C(=O)N3CCCC3)C2)ncc1[N+](=O)[O-]>>Nc1cnc(N2CCO[C@@H](C(=O)N3CCCC3)C2)nc1N,[Pd],CCO,,[H][H],,val
US20080064678A1,C1CCNC1.CC#N.CC(C)NC(=O)Cn1c(-c2cccc(Cl)c2)cc2ccc(OC[C@@H](C)COS(C)(=O)=O)cc2c1=O.O>>CC(C)NC(=O)Cn1c(-c2cccc(Cl)c2)cc2ccc(OC[C@@H](C)CN3CCCC3)cc2c1=O.[NH4+].[OH-],,CC#N,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20100130538A1,Cn1cc2c([C@H]3C[C@H]3CN3C(=O)c4ccccc4C3=O)cccc2n1>>Cn1cc2c([C@H]3C[C@H]3CN)cccc2n1,,CCO,,NN,O,val
US20070105919A1,C1COCCN1.O=C(Nc1nc(-c2ccco2)c(C(=O)C2CCOCC2)s1)c1ccc(Cl)nc1>>O=C(Nc1nc(-c2ccco2)c(C(=O)C2CCOCC2)s1)c1ccc(N2CCOCC2)nc1,,C1COCCO1,,,,val
US06482478B1,OB(O)C1(F)C=CC=CC1Br.OO>>Oc1cccc(Br)c1F,,COC(C)(C)C,,O,,val
US20160264579A1,CC(C)(C)OC(=O)N1CCC(n2cc(I)c3c(Cl)ncnc32)CC1.O=C(O)C(F)(F)F>>Clc1ncnc2c1c(I)cn2C1CCNCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20070004736A1,CC(C)(C)OC(=O)N1CCC(CBr)CC1.Cc1ncc[nH]1>>Cc1nccn1CC1CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,[H-].[Na+],,val
US05051413,CCOP(=O)(C/C=C/C(C)(NC=O)C(=O)OC)OCC>>CC(N)(/C=C/CP(=O)(O)O)C(=O)O,,Cl,,O,,val
US05374656,CC(C)(C)OC(=O)CN(C(=O)CN)c1ccccc1.Nc1cnc2ccccc2c1.O=C(Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)CN(C(=O)CNC(=O)Nc1cnc2ccccc2c1)c1ccccc1,,ClCCl,O,CCN(CC)CC,,val
US06605124B1,CS(=O)(=O)Nc1cccc2c(O)c(NC(=O)CCl)ccc12.Cn1ccnc1>>C[n+]1ccn(CC(=O)Nc2ccc3c(NS(C)(=O)=O)cccc3c2O)c1.[Cl-],,C1CCOC1,,,,val
US04021432,C=CCBr.C=CCOC1CC(C)(C)NC(C)(C)C1>>Br.C=CCOC1CC(C)(C)NC(C)(C)C1,,CCOCC,,,,val
US20120238517A1,CC(C)(C)OC(=O)NC1CONC1=O.OCCBr>>CC(C)(C)OC(=O)N[C@@H]1CON(CCO)C1=O,,CC#N,,[I-].[K+],,val
US20060205718A1,CI.NS(=O)(=O)c1ccc2oc(S)nc2c1>>CSc1nc2cc(S(N)(=O)=O)ccc2o1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120225895A1,C=CC(C)(C)CC[Mg]Br.Cc1ccc(N=C=S)cc1>>C=CC(C)(C)CCC(=S)Nc1ccc(C)cc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20160039780A1,CC(=O)OC(C)=O.CC1(C)Cc2cccc(O)c2O1>>CC(=O)Oc1cccc2c1OC(C)(C)C2,,ClCCl,,O,c1ccncc1,val
US05741819,COC(=O)c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1>>O=C(O)c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1,,[Na+],[OH-],,,val
US20040235875A1,CSc1nccc(C(=O)/C(=C/N(C)C)c2ccccc2)n1.NN>>CSc1nccc(-c2[nH]ncc2-c2ccccc2)n1,,CCO,,Cl,,val
US20140038919A1,CC(C)(C)[Si](C)(C)OCCCCN(c1cc2oc(-c3ccc(F)cc3)c(C(=N)NO)c2cc1C1CC1)S(C)(=O)=O>>CS(=O)(=O)N(CCCCO)c1cc2oc(-c3ccc(F)cc3)c(C(=N)NO)c2cc1C1CC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150065482A1,COC(=O)c1nn(-c2cc(C#C[C@]3(O)CCN(C)C3=O)cc(C(C)O)c2)c2ncccc12.N>>CC(O)c1cc(C#C[C@]2(O)CCN(C)C2=O)cc(-n2nc(C(N)=O)c3cccnc32)c1,,CO,,,,val
US20140005226A1,COC(=O)c1ccc([C@H](C)NC(=O)[C@H]2CCCCN2CCOc2ccccc2)cc1.Cl>>C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1.Cl,,C1CCOC1,CO,[Na+].[OH-],,val
US20140148468A1,CCOC(=O)c1sc(C)nc1O.CN(C)C(=S)Cl>>CCOC(=O)c1sc(C)nc1OC(=S)N(C)C,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US04301171,c1ccc2c(c1)OCC(Cc1nc3ccccc3[nH]1)O2>>c1ccc2c(c1)OCC(Cc1nc3ccccc3[nH]1)O2,,CCOCC,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120245152A1,CC(C)(C)OC(=O)C(C)(C)Br.Oc1cc(Cl)cnc1Cl>>CC(C)(C)OC(=O)C(C)(C)Oc1cc(Cl)cnc1Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080234255A1,CCCI.CCOC(=O)CCNC1CCCC1>>CCCC(CNC1CCCC1)C(=O)OCC,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100292235A1,NCc1ccc(C(F)(F)F)nc1.O=c1occc2c([N+](=O)[O-])cccc12>>O=c1c2cccc([N+](=O)[O-])c2ccn1Cc1ccc(C(F)(F)F)nc1,,CO,,,,val
US20120108638A1,CO.O=C(O)c1cc(Cl)nc(Cl)c1>>COc1cc(C(=O)O)cc(Cl)n1,,[Na+],[OH-],Cl,,val
US04656189,O=C1CCOc2ccccc21>>C1=Cc2ccccc2OC1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20020103243A1,CN(C)S(=O)(=O)Cl.O=C(c1ccc(C(F)(F)F)cc1)c1nc[nH]n1>>CN(C)S(=O)(=O)n1cnc(C(=O)c2ccc(C(F)(F)F)cc2)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130296329A1,COCc1cc2c(cc1C(=O)OC)[nH]c(=O)c1cnc(C3CCOC3)n12>>COCc1cc2c(cc1C(=O)O)[nH]c(=O)c1cnc(C3CCOC3)n12,,CO,,Cl,[Na+].[OH-],val
US20030225266A1,CC(CNS(=O)(=O)C(C)C)Oc1ccc(Br)cc1.OB(O)c1cccc(Cl)c1>>CC(CNS(=O)(=O)C(C)C)Oc1ccc(-c2cccc(Cl)c2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20050119489A1,CC(C)(C)C(=O)Cl.Cc1nn(CCNC(=O)OC(C)(C)C)c(C)c1S(=O)(=O)c1ccc(N)cc1>>Cc1nn(CCNC(=O)OC(C)(C)C)c(C)c1S(=O)(=O)c1ccc(NC(=O)C(C)(C)C)cc1,,ClCCl,,c1ccncc1,,val
US20070232583A1,Cc1cc(-c2ccc(Cl)c(Cl)c2)nc(-n2cnc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)c2)n1>>Cc1cc(-c2ccc(Cl)c(Cl)c2)nc(-n2cnc(-c3ccc(S(N)(=O)=O)cc3)c2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130184284A1,CC(C)(C)OC(=O)N1CCC[C@](C)(NC(=O)OCc2ccccc2)C1>>C[C@]1(NC(=O)OCc2ccccc2)CCCNC1,,C1COCCO1,,Cl,,val
US20100016272A1,Cc1nc(-c2ccccc2)sc1C=O.O=C(O)CC(=O)O>>Cc1nc(-c2ccccc2)sc1C=CC(=O)O,,c1ccncc1,,C1CCNCC1,,val
US20060074075A1,CC(C)I.O=[N+]([O-])c1ccc2cc[nH]c2c1>>CC(C)c1c[nH]c2cc(N)ccc12,,CC#N,,,,val
US20040072827A1,CC(C)(C)OC(=O)NCCCn1c(-c2ccc(-c3ccccc3)cc2)csc1=Nc1ccccc1>>NCCCn1c(-c2ccc(-c3ccccc3)cc2)csc1=Nc1ccccc1,,C1COCCO1,,Cl,O,val
US20110263556A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1ccc(Cl)c(C(=O)O)c1>>CC(C)(C)OC(=O)NCc1ccc(Cl)c(C(=O)O)c1,,C1CCOC1,,[Na+].[OH-],,val
US03996233,CCNCc1ccccc1.CCOC(=O)c1c(C)nc(Cl)c([N+](=O)[O-])c1Cl>>CCOC(=O)c1c(C)nc(N(CC)Cc2ccccc2)c([N+](=O)[O-])c1Cl,,CCN(CC)CC,,,,val
US20100216746A1,CCN.N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CBr)c2F)c1>>CCNCc1ccc(Cl)c(Oc2cc(Cl)cc(C#N)c2)c1F,,C1CCOC1,,CCOC(C)=O,O=C([O-])O.[Na+],val
US20050131014A1,O=C(c1ccccc1)c1cnc2c(C(F)(F)F)cccc2c1-c1cccc(O)c1.O=[N+]([O-])c1ccccc1CBr>>O=C(c1ccccc1)c1cnc2c(C(F)(F)F)cccc2c1-c1cccc(OCc2ccccc2[N+](=O)[O-])c1,,CN(C)C=O,,,,val
US20030013886A1,COc1ccc([N+](=O)[O-])c(N)c1.FC(F)(F)c1ccc2c(c1)nc(/C=C/c1ccccc1)n2-c1ccccn1.O=C(O)C(=O)O>>COc1ccc2nc(/C=C/c3ccccc3)n(-c3ccccn3)c2c1.O=C(O)C(=O)O,,CCOC(C)=O,,,,val
US20100272680A1,CI.COC(=O)c1nc2c(C(F)(F)F)cc(O)cn2c1Cl>>COC(=O)c1nc2c(C(F)(F)F)cc(OC)cn2c1Cl,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20140148433A1,COC(=O)NCCc1c(N)nc(-c2nn(Cc3ccccc3F)c3ncccc23)nc1N>>CCn1c(=O)[nH]c2nc(-c3nn(Cc4ccccc4F)c4ncccc34)nc(N)c21,,C1CCOC1,,O,,val
US20090186879A1,CCOC(=O)CCCn1c(Nc2ccc(OC)nc2OC)nc2c(Cl)ccc(C(CC)CC)c21>>CCC(CC)c1ccc(Cl)c2nc(Nc3ccc(OC)nc3OC)n(CCCCO)c12,,C1CCOC1,,O,[BH4-].[Li+],val
US20060229447A1,N#CN=C(Oc1ccccc1)Oc1ccccc1.N[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O.O=c1[nH]c2ccccc2cc1C1CCNCC1>>N#CN=C(N[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(c2cc3ccccc3[nH]c2=O)CC1,,CN(C)C=O,CO,CCN(C(C)C)C(C)C,Cl,val
US20100291026A1,Cc1ccc(S(=O)(=O)n2ccc3c(N(C)C4CN(Cc5ccccc5)CCC4C)ncnc32)cc1>>CC1CCN(Cc2ccccc2)CC1N(C)c1ncnc2[nH]ccc12,,CCOC(C)=O,,[Na+].[OH-],,val
US20110195980A1,CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccnc3ccc(-c4nccc(=O)[nH]4)cc23)C1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccnc3ccc(-c4nccc(OS(=O)(=O)C(F)(F)F)n4)cc23)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04424359,Cc1ccc(CBr)nc1-c1ccccn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ccc(C=C2C=CC=CC2[PH+](c2ccccc2)c2ccccc2)nc1-c1ccccn1.[Br-],,CN(C)C=O,,CCOCC,,val
US20090137561A1,CCI.COC(=O)c1ccc(-c2cc(OC)ccc2F)c(CO)c1>>CCOCc1cc(C(=O)OC)ccc1-c1cc(OC)ccc1F,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20080194837A1,CC(=O)Oc1coc2cc(C(F)(F)F)ccc12>>O=C1COc2cc(C(F)(F)F)ccc21,,O,,CO,Cl,val
US04826990,Cc1oc(-c2ccccc2)nc1COc1cccc([N+](=O)[O-])c1>>Cc1oc(-c2ccccc2)nc1COc1cccc(N)c1,,CCO,,O=C([O-])O.[Na+],,val
US20150368188A1,COC(=O)[C@@H](C)C[C@H](NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1>>COC(=O)[C@@H](C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O,[Pd],CO,,,,val
US20110009454A1,NCc1ccccc1Cl.Nc1ncccc1C(=O)O>>Nc1ncccc1C(=O)NCc1ccccc1Cl,,CN(C)C=O,O,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20100081817A1,CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)C=C[C@@]3(O)[C@H]1C5.O=CC1CC1>>O=C1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5,,CC#N,,CCN(CC)CC,O=CO,val
US04753953,C=C(C)C(=O)OCC.NCc1ccccc1>>CCOC(=O)C(C)CNCc1ccccc1,,CCO,,,,val
US20150051225A1,CC1(C)CC(C(=O)Cl)CC(C)(C)O1.C[Si](C)(C)C=[N+]=[N-]>>CC1(C)CC(C(=O)C=[N+]=[N-])CC(C)(C)O1,,ClCCl,,,,val
US06140349,CNCC(C)(CC=C(C)C)c1ccccc1.O=S(=O)(Cl)c1ccccc1>>CC(C)=CCC(C)(CN(C)S(=O)(=O)c1ccccc1)c1ccccc1,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US07396844B1,N#Cc1cccc(O)c1.OCCBr>>N#Cc1cccc(OCCBr)c1,,C1CCOC1,CCOC(C)=O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130336920A1,CNCCC(=O)NCCOC.O=C(NCc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(N3CCCCC3)ccc2NC(=O)c2cccc(CBr)c2)c1>>COCCNC(=O)CCN(C)Cc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1,,CCOC(C)=O,CN(C)C=O,[I-].[K+],,val
US20100280083A1,COc1cc(-c2noc(C)n2)c(S(C)(=O)=O)cc1OCc1ccccc1>>COc1cc(-c2noc(C)n2)c(S(C)(=O)=O)cc1O,Cl[Ti](Cl)(Cl)Cl,ClCCl,,Cl,,val
US20020049204A1,CCN(CC)CC.CCO.O=c1[nH]c2ccc(Br)cc2c(=O)o1>>CON(C)C(=O)c1cc(Br)ccc1N,,O,,,,val
US20040138286A1,COCCBr.c1cc2[nH]ncc2cc1OC1CCNCC1>>COCCN1CCC(Oc2ccc3[nH]ncc3c2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20050222225A1,C=CC(=O)OCC.O=Cc1ccc2occ(Br)c2c1>>CCOC(=O)C=Cc1coc2ccc(C=O)cc12,,CC#N,,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090198063A1,Cc1ccc(CNC2CCN(CCn3c(=O)ccc4ccncc43)CC2)cc1F.Cl>>Cc1ccc(CNC2CCN(CCn3c(=O)ccc4ccncc43)CC2)cc1F.Cl,,CCOC(C)=O,,,,val
US20050209309A1,CON(C)C(=O)c1ccc(Cc2ccccc2O)cc1.C[Mg]Br>>CC(=O)c1ccc(Cc2ccccc2O)cc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20100197706A1,CCCC(CCC)n1ccc2c(C(=O)N[C@@H](Cc3ccccc3)[C@H](O)CNCc3cccc(C(F)(F)F)c3)cccc2c1=O.Cl>>CCCC(CCC)n1ccc2c(C(=O)N[C@@H](Cc3ccccc3)[C@H](O)CNCc3cccc(C(F)(F)F)c3)cccc2c1=O.Cl,,C1COCCO1,CCOCC,,,val
US20100227877A1,CCOC(=O)[C@H](C)O[Si](C)(C)C(C)(C)C>>C[C@H](O[Si](C)(C)C(C)(C)C)C(=O)O,,C1CCOC1,,[Li+].[OH-],,val
US20110034440A1,CCOC(=O)CN(CC(=O)OCC)c1cc(C(N)=O)ccc1C>>Cc1ccc(C#N)cc1N(CC(=O)O)CC(=O)O,,C1CCOC1,CO,[Na+].[OH-],,val
US20050239827A1,Clc1nc(Cl)nc(Cl)n1.Nc1ccc(NC(=O)c2ccc(OCc3ccccc3)cc2OCc2ccccc2)c(O)c1>>O=C(Nc1ccc(Nc2nc(Cl)nc(Cl)n2)cc1O)c1ccc(OCc2ccccc2)cc1OCc1ccccc1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20150361101A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cc(-c4cc5c(F)cccc5[nH]4)c(C=C(C)C)cn3)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cc4c(cn3)CC(C)(C)n3c-4cc4c(F)cccc43)cc12,,CC(=O)N(C)C,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20030153752A1,CCOC(=O)C(C)Br.Nc1ncnc2[nH]cc(-c3ccc(Oc4ccccc4)cc3)c12>>CCOC(=O)C(C)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21,,CN(C)C=O,CN(C)C=O,[H-].[Na+],,val
US07220769B2,COc1cc(C#N)ccc1C(=O)Nc1cc(Cl)c(Cl)cc1N>>COc1cc(C#N)ccc1-c1nc2cc(Cl)c(Cl)cc2[nH]1,,Cc1ccccc1C,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20150315198A1,CC(C)(C)OC(=O)NCc1nc2cc(Cl)ccn2c1C#N>>N#Cc1c(CN)nc2cc(Cl)ccn12,,CCOC(C)=O,,,,val
US20040024034A1,CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccc(OC)cc3)oc2C)cc1>>COc1ccc(-c2nc(CCOc3ccc(OC(C)(C)C(=O)O)cc3)c(C)o2)cc1,,CCO,,[Na+].[OH-],,val
US05891909,COc1ccc(OC)c(S(=O)(=O)Oc2cc(C)cc(OCCCO)c2)c1>>COc1ccc(OC)c(S(=O)(=O)Oc2cc(C)cc(OCCC=O)c2)c1,,ClCCl,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20070275968A1,CC(C)(C)OC(=O)n1ccc(Br)c1.Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(B3OC(C)(C)C(C)(C)O3)c2)n1>>Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(-c3ccn(C(=O)OC(C)(C)C)c3)c2)n1,,CCOC(C)=O,COCCOC,,,val
US20140256736A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1noc2ccc(Br)cc12.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1noc2ccc(B3OC(C)(C)C(C)(C)O3)cc12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,CC(=O)[O-].[K+],,val
US05578620,C[C@H](COc1ccc(CC2SC(=O)N(C(c3ccccc3)(c3ccccc3)c3ccccc3)C2=O)cc1)N1C[C@@H](COc2cccc(Cl)c2)OC1=O>>C[C@H](COc1ccc(CC2SC(=O)NC2=O)cc1)N1C[C@@H](COc2cccc(Cl)c2)OC1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040186102A1,Cc1cc(Cl)c2ccccc2n1.Cc1ccc(N)cc1OCCN(C)C>>Cc1cc(Nc2ccc(C)c(OCCN(C)C)c2)c2ccccc2n1,Cl,CCO,,,,val
US20150329653A1,BrBr.CC(=O)c1ccc(C)cc1>>CC(=O)c1ccc(C)c(Br)c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20150361100A1,C=C(C(=O)OCC)C(O)c1ccc(C(F)(F)F)cn1>>CCOC(=O)c1cc2ccc(C(F)(F)F)cn2c1,,CC(=O)OC(C)=O,,,,val
US20110021522A1,COc1ncccc1B(O)O.Nc1cccc(Br)c1>>COc1ncccc1-c1cccc(N)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US20140194431A1,CC(C)(C)[Si](C)(C)OCCNC1COC1.O=C(O)c1nc(CC2(c3ccccc3)CCCC2)nc(O)c1OCc1ccccc1>>CC(C)(C)[Si](C)(C)OCCN(C(=O)c1nc(CC2(c3ccccc3)CCCC2)nc(O)c1OCc1ccccc1)C1COC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020028832A1,CCCCCCCCNC(=O)N1CCC(C(=O)N2CCC(Nc3ccc(CCNC[C@H](O)COc4ccc(O[Si](c5ccccc5)(c5ccccc5)C(C)(C)C)cc4)cc3)CC2)CC1>>CCCCCCCCNC(=O)N1CCC(C(=O)N2CCC(Nc3ccc(CCNC[C@H](O)COc4ccc(O)cc4)cc3)CC2)CC1,,CO,ClC(Cl)Cl,,,val
US20110319378A1,CO.O=C(O)C[C@@H]1C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N(CC2CC2)C1=O>>COC(=O)C[C@@H]1C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N(CC2CC2)C1=O,,CO,ClCCl,C[Si](C)(C)C=[N+]=[N-],,val
US20080269196A1,N#Cc1ccc(CBr)cc1.SC1CCCC1>>N#Cc1ccc(CSC2CCCC2)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20130331378A1,COC(=O)c1cccc(Cc2c(-c3ccc(F)cc3)nn3cc(OC)ccc23)n1>>COc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccc(F)cc3)nn2c1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US06063806,BrBr.CCOC(=O)CCC1CN(C(C)=O)c2cc(C)cc(C)c21>>CCOC(=O)CCC1CN(C(C)=O)c2cc(C)c(Br)c(C)c21,,CC(=O)O,,,,val
US20050148624A1,COC(=O)c1ccc(CN)cc1.COC(=O)c1oc(=O)c2ccc(Br)cc2c1-c1ccccc1>>COC(=O)c1ccc(Cn2c(C(=O)OC)c(-c3ccccc3)c3cc(Br)ccc3c2=O)cc1,,CO,,,,val
US05663346,NS(=O)(=O)c1ccc2c(c1)CC(=O)N2.O=Cc1c[nH]c2ncccc12>>NS(=O)(=O)c1ccc2c(c1)C(=Cc1c[nH]c3ncccc13)C(=O)N2,,CCO,,C1CCNCC1,,val
US20030176454A1,CCOC(=O)C1CCOc2ccc(C)cc2C1=O.NO>>Cc1ccc2c(c1)-c1noc(O)c1CCO2,,CCO,CCOC(C)=O,Cl,,val
US20150038574A1,CC1=C(C=O)C(C)(C)CCC1.CCOc1cccc(N)c1>>CCOc1cccc(NCC2=C(C)CCCC2(C)C)c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20060173018A1,Cc1ccc2c(N3CCC[C@H](CN)C3)nc(-c3ccccc3O)nc2c1.O=C(Cl)O[C@H]1CCOC1>>Cc1ccc2c(N3CCC[C@H](CNC(=O)O[C@H]4CCOC4)C3)nc(-c3ccccc3O)nc2c1,,CN(C)C=O,,CCN(CC)CC,,val
US20080312272A1,CC(C#N)(Cn1cc2ccc(Cl)cc2n1)NC(=O)c1ccc(OC(F)(F)F)cc1.O=C1CCC(=O)N1Br>>CC(C#N)(Cn1nc2cc(Cl)ccc2c1Br)NC(=O)c1ccc(OC(F)(F)F)cc1,,CC#N,O,,,val
US20110015157A1,CS(=O)(=O)Cl.C[C@@H](C1CCCCC1)N1CC[C@](CCCO)(c2ccc(F)cc2)OC1=O>>C[C@@H](C1CCCCC1)N1CC[C@](CCCOS(C)(=O)=O)(c2ccc(F)cc2)OC1=O,,ClCCl,,CCN(CC)CC,,val
US20070054915A1,CCS(=O)(=O)Cl.Nc1n[nH]c2nc(Oc3ccc(F)cc3F)ncc12>>CCS(=O)(=O)Nc1n[nH]c2nc(Oc3ccc(F)cc3F)ncc12,,C1COCCO1,,c1ccncc1,,val
US05859007,COc1cccc(N(c2ccccc2)C(C)C)c1.O=C(Br)CBr>>COc1cccc(N(C(=O)CBr)C(C)C)c1,,ClCCl,,CCN(CC)CC,,val
US20020013341A1,COC(=O)CC1(N)CCOCC1.Cc1cc(Cn2ccc3cc(C(=O)Cl)ccc32)c2c(n1)CC=CC2>>COC(=O)CC1(NC(=O)c2ccc3c(ccn3Cc3cc(C)nc4c3CC=CC4)c2)CCOCC1,,ClCCl,O,,,val
US20020120007A1,COc1ccc(NC(=O)c2cc([N+](=O)[O-])ccc2NC(=O)c2ccc(C(C)(C)C)cc2)cc1>>COc1ccc(NC(=O)c2cc(N)ccc2NC(=O)c2ccc(C(C)(C)C)cc2)cc1,[Pd],CCO,,CCOC(C)=O,,val
US20160214997A1,CS(=O)(=O)OCCc1nc2c3ccc4c(c3nc(N)n2n1)OC(F)(F)O4.c1cnc2c(c1)CNC2>>Nc1nc2c3c(ccc2c2nc(CCN4Cc5cccnc5C4)nn12)OC(F)(F)O3,,CN(C)C=O,,CCN(C(C)C)C(C)C,[I-].[K+],val
US20100292210A1,C=O.CC(C)OCC1CNCc2ccc(Cl)nc2O1>>CC(C)OCC1CN(C)Cc2ccc(Cl)nc2O1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20160002158A1,CCOC(=O)c1ccc(N)c(OC)c1.O=C(Cl)CCl>>CCOC(=O)c1ccc(NC(=O)CCl)c(OC)c1,,CC(=O)O,O,CC(=O)[O-].[Na+],,val
US20070142638A1,COC(=O)c1ccc(CCNC(=O)[C@H](CCCN)NC(=O)c2cc3ccccc3o2)cc1.O=C(O)CCc1ccccc1>>COC(=O)c1ccc(CCNC(=O)[C@H](CCCNC(=O)CCc2ccccc2)NC(=O)c2cc3ccccc3o2)cc1,,CN(C)C=O,,On1nnc2ccccc21,,val
US20160200686A1,CCOc1ccc(C[C@@H](NC(=O)OC(C)(C)C)c2nc3ccccc3[nH]2)cc1.Cl.ClCCl>>CCOc1ccc(C[C@@H](N)c2nc3ccccc3[nH]2)cc1.Cl.Cl,,C1COCCO1,ClCCl,N#N,,val
US20020052400A1,N#CC=C1CCOc2ccccc21>>N#CCC1CCOc2ccccc21,[Pd],CCO,,,,val
US20140357666A1,CCCCN(CCCC)C(=O)c1cc(C)n(-c2ccc(NC(=O)NCc3ccccc3)cc2C(=O)N2Cc3ccccc3C[C@H]2CO[Si](C)(C)C(C)(C)C)n1>>CCCCN(CCCC)C(=O)c1cc(C)n(-c2ccc(NC(=O)NCc3ccccc3)cc2C(=O)N2Cc3ccccc3C[C@H]2CO)n1,,C1CCOC1,O,Cl,O=C([O-])O.[Na+],val
US04316042,C#CC(=O)c1ccc(F)cc1.C=C(C)C=CN(C(=O)OC)C(C)C>>COC(=O)N(C(C)C)C1C=C(C)CC=C1C(=O)c1ccc(F)cc1,,CCCCCC,,,,val
US20100137278A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C1(c2nccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CCN(C(=O)OC(C)(C)C)CC1>>COC(=O)C1(c2nccnc2Oc2ccc(N(C(=O)OC(C)(C)C)c3nc4ccccc4s3)cc2)CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,C1CCOC1,,val
US20020169322A1,CCN(CC)CCn1ncc2ccc(C3CCN(C(=O)OC(C)(C)C)CC3)cc21>>CCN(CC)CCn1ncc2ccc(C3CCN(C)CC3)cc21,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05143912,O=C(OCc1ccccc1)c1cc(-c2ccccc2)c(=O)n2c1-c1ccccc1C2>>O=C(O)c1cc(-c2ccccc2)c(=O)n2c1-c1ccccc1C2,[Pd],CCO,O,O=C([O-])[O-].[Na+].[Na+],,val
US20030229092A1,CN(C)S(=O)(=O)n1ccnc1-c1cc(Cl)nc(Cl)n1>>Clc1cc(-c2ncc[nH]2)nc(Cl)n1,,Cl,,O=C([O-])O.[Na+],,val
US20140088079A1,Br.CC(=O)OC1O[C@@H](c2ccc(Cl)c(Cc3ccc4c(c3)OCCO4)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(=O)O[C@H]1[C@H](c2ccc(Cl)c(Cc3ccc4c(c3)OCCO4)c2)O[C@@H](Br)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,CC(=O)O,ClCCl,,,val
US20160016966A1,CI.COc1ccc(-c2n[nH]c(=O)c3cc(C(=O)N4CCN(S(C)(=O)=O)CC4)oc23)cc1OC>>COc1ccc(-c2nn(C)c(=O)c3cc(C(=O)N4CCN(S(C)(=O)=O)CC4)oc23)cc1OC,,CN(C)C=O,,O,[H-].[Na+],val
US05219862,C=Cc1[nH]c2cccc3c2c1C[C@@H]1[C@@H]3C[C@@H](C(=O)OC)CN1CCC>>CCCN1C[C@H](C(=O)OC)C[C@@H]2c3cccc4[nH]c(CC)c(c34)C[C@H]21,[Pd],CO,,,,val
US20110183998A1,Clc1ccc(OCc2ccccc2)cn1.OC1COC(c2ccccc2)OC1>>c1ccc(COc2ccc(OC3COC(c4ccccc4)OC3)nc2)cc1,,CN1CCCC1=O,,[H-].[Na+],,val
US20040102484A1,Cc1ccc(S(=O)(=O)CCOC(=O)COc2ccccc2)cc1.O=S(=O)(O)Cl>>Cc1ccc(S(=O)(=O)CCOC(=O)COc2ccc(S(=O)(=O)Cl)cc2)cc1,,ClCCl,,,,val
US20040136906A1,O=C(O)c1ccccc1CN1C(=O)c2ccccc2C1=O>>NCc1ccccc1C(=O)O,,CCO,,CN,,val
US20080255152A1,NC(=O)c1cnc(Oc2ccc(C=O)cc2F)cn1.NCCc1ccc(F)cc1>>NC(=O)c1cnc(Oc2ccc(CNCCc3ccc(F)cc3)cc2F)cn1,,CO,,[BH4-].[Na+],,val
US05800733,C=CC(=O)O.O=Cc1ccc(-c2ncc(OCCCCCCCCO)cn2)cc1>>C=CC(=O)OCCCCCCCCOc1cnc(-c2ccc(C=O)cc2)nc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100305133A1,COC(=O)c1c(OC)cc(Br)c([N+](=O)[O-])c1N.O=CC=O>>COC(=O)c1c(OC)cc(Br)c2nccnc12,[Pd],CO,,[H][H],,val
US20110144194A1,C#CCCCCCCCCCCOCc1ccccc1.COc1ccc(-c2cc(=O)c3c(OC)c(I)c(OC)cc3o2)cc1OC>>COc1ccc(-c2cc(=O)c3c(cc(OC)c4cc(CCCCCCCCCCOCc5ccccc5)oc43)o2)cc1OC,[Cu]I,C1CCNCC1,,,,val
US04426536,CCCCO.FC(F)(F)c1cccc(CC(Cl)(Cl)Cl)c1.O=S(=O)(O)O>>CCCCOC(=O)Cc1cccc(C(F)(F)F)c1,,CCCCO,,O,[K+].[OH-],val
US20130261077A1,CC(=O)CCl.CC(=O)OC[C@H]1O[C@H](c2cccc(Oc3ccc(N)nc3)c2)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@H](c2cccc(Oc3ccc4nc(C)cn4c3)c2)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,CN(C)C=O,,,,val
US20080058320A1,CC(C)CC(=O)N1C(=O)OC[C@H]1Cc1ccccc1.COCCOc1cccc2ccc(CBr)cc12>>COCCOc1cccc2ccc(CC(C(=O)N3C(=O)OC[C@H]3Cc3ccccc3)C(C)C)cc12,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20150368248A1,CC(C)(O)CN.Clc1nc(NCc2ccc(-c3ccco3)nc2)c2ncn(C3CCCC3)c2n1>>CC(C)(O)CNc1nc(NCc2ccc(-c3ccco3)nc2)c2ncn(C3CCCC3)c2n1,,CCOC(C)=O,CO,CCN(C(C)C)C(C)C,,val
US20070042292A1,CC(C)(C)OC(=O)CBr.Oc1cccc2ccccc12>>CC(C)(C)OC(=O)COc1cccc2ccccc12,,CCOC(C)=O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20090029994A1,CCCN(CC1CC1)c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C#N)c1CC)c1ncc(O)cn1.O=C([O-])CCCBr>>CCCN(CC1CC1)c1ccc(C(F)(F)F)cc1CN(Cc1cc(C#N)cc(C(F)(F)F)c1)c1ncc(OCCCC(=O)OCC)cn1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US05023364,CCCc1c(OCc2ccccc2)ccc(C(C)=O)c1OCCCC(=O)OCC>>CCCc1c(O)ccc(C(C)=O)c1OCCCC(=O)OCC,[Pd],CCO,,,,val
US20160039834A1,CO.Fc1ccc(C(F)(F)F)c(Br)c1>>COc1ccc(C(F)(F)F)c(Br)c1,,CN(C)C=O,O,[H-].[Na+],,val
US20120165338A1,COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)OCC3c4ccccc4-c4ccccc43)COC2)c(F)c1>>COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(N)COC2)c(F)c1,,CN(C)C=O,,C1CCNCC1,,val
US04783537,CNC(=O)C(CCCN(C)C)c1ccccc1.O=Cc1ccccc1>>CNC(=O)C(CCCN(C)C)(c1ccccc1)C(O)c1ccccc1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20080261977A1,COC(=O)c1cnc(Cl)nc1C(F)(F)F.Nc1cccc(Cl)c1>>COC(=O)c1cnc(Nc2cccc(Cl)c2)nc1C(F)(F)F,,C1COCCO1,,,,val
US20100297054A1,Cc1c(C(=O)Nc2cc(CO)cc(CO)c2)nnn1Cc1ccc(Cl)c(Cl)c1>>Cc1c(CNc2cc(CO)cc(CO)c2)nnn1Cc1ccc(Cl)c(Cl)c1,,CC#N,,,,val
US20150045359A1,CC(C)(C)OC(=O)N1CCOC(c2ccc(Br)c(F)c2)C1.N#C[Cu]>>CC(C)(C)OC(=O)N1CCOC(c2ccc(C#N)c(F)c2)C1,,COC(C)(C)C,,,,val
US05162312,COC1=CCC2=C(CC[C@@H]3[C@@H]2CC[C@@]2(C)[C@H]3C[C@H]3C[C@]32OC)C1>>CO[C@@]12C[C@@H]1C[C@H]1[C@@H]3CCC4=C(CCC(=O)C4)[C@H]3CC[C@@]12C,,CC(C)=O,,O,O=S(=O)(O)O,val
US20080045561A1,CO.COc1cc2c(nc1OC)c(-c1cc3c(Cl)ccnc3[nH]1)cn2CCCN1CCC(O)CC1.COc1cc2c(nc1OC)c(-c1cc3c(Cl)ccnc3n1S(=O)(=O)c1ccc(C)cc1)cn2CCCN1CCC(O)CC1>>COc1cc2c(nc1OC)c(-c1cc3c(Cl)ccnc3[nH]1)cn2CCCN1CCC(CCO)CC1,,CO,,[K+].[OH-],,val
US20100273764A1,CC(C)OB(OC(C)C)OC(C)C.COc1ccc(COCc2cnc(F)c(Br)c2)cc1>>COc1ccc(COCc2cnc(F)c(B(O)O)c2)cc1,,Cc1ccccc1,,[Li]CCCC,,val
US06107301,Cc1cc(C)c2c(C#N)cn(-c3ccc(C(C)C)cc3Br)c2n1>>Cc1cc(C)c2ccn(-c3ccc(C(C)C)cc3Br)c2n1,,O=S(=O)(O)O,,[NH4+].[OH-],,val
US20040122063A1,CCOC(=O)[C@@H]1CC[C@@H](NC(=O)c2nc3c(s2)CN(C)CC3)[C@@H](NC(=O)OC(C)(C)C)C1.O=C(O)c1cc2cc(Cl)ccc2[nH]1>>CCOC(=O)[C@@H]1CC[C@@H](NC(=O)c2nc3c(s2)CN(C)CC3)[C@@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)C1,,CCO,,Cl,,val
US20020193367A1,Cc1cc(-c2cccc(C(=O)CC(=O)Nc3cc(C#N)c(N4CCCCC4)cc3NC(=O)OC(C)(C)C)c2)on1>>Cc1cc(-c2cccc(C3=Nc4cc(N5CCCCC5)c(C#N)cc4NC(=O)C3)c2)on1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080242672A1,COc1ccccc1N1CCN(CCCl)CC1.Nc1nc2[nH]ccc2c2nc(-c3ccco3)nn12>>COc1ccccc1N1CCN(CCn2ccc3c2nc(N)n2nc(-c4ccco4)nc32)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US04198425,BrBr.CCOC(=O)CC(C)(O)C=CCCc1ccc(Cl)cc1>>CC1(O)CC(=O)OC(CCc2ccc(Cl)cc2)C1Br,,CO,,[Na+].[OH-],,val
US06265411B1,COc1cc(C(=O)O)ccc1OCCCN1CCOCC1.O=[N+]([O-])O>>COc1cc(C(=O)O)c([N+](=O)[O-])cc1OCCCN1CCOCC1,,O=C(O)C(F)(F)F,,,,val
US20130287699A1,N#Cc1nc2ccc(O)cc2s1.OCc1ccc(B(O)O)cc1>>N#Cc1nc2ccc(OCc3ccc(B(O)O)cc3)cc2s1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070254875A1,CC[C@@H](N)CO.N#Cc1ccc(F)c(F)c1>>CCC(CO)Nc1ccc(C#N)cc1F,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20120015941A1,NCCO.O=C(NCc1cccc(F)c1)Nc1nc(CI)cs1>>O=C(NCc1cccc(F)c1)Nc1nc(CNCCO)cs1,,C1CCOC1,,O,,val
US20140187542A1,COc1ccc2ncc(=O)n(CC[C@H](O)CO)c2n1.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1ccc2ncc(=O)n(CC[C@H](O)COS(=O)(=O)c3ccc(C)cc3)c2n1,,ClCCl,O,CCN(CC)CC,CN(C)c1ccccn1,val
US20140256740A1,CC(C)C(=O)Cl.CCOC(=O)CC(=O)C(C)C>>CCOC(=O)C(C(=O)C(C)C)C(=O)C(C)C,,c1ccccc1,,O,,val
US05068367,N#CC1=C(C#N)C(=O)C(C#N)=C(C#N)C1=O.c1ccc2c(c1)Cc1ccccc1C2>>N#CC1=C(C#N)C(=O)C(C#N)=C(C#N)C1=O.c1ccc2cc3ccccc3cc2c1,,CC#N,,,,val
US05223499,Cc1ccnc(N)c1[N+](=O)[O-].O=[N+]([O-])O>>Cc1c([N+](=O)[O-])cnc(N)c1[N+](=O)[O-],,O=S(=O)(O)O,,,,val
US20040127574A1,COC(=O)c1ccc(CO)c2ccccc12>>O=C(O)c1ccc(CO)c2ccccc12,,CO,,Cl,[Na+].[OH-],val
US20090093497A1,CN(C(=O)OC(C)(C)C)C1CCN(c2ccc([N+](=O)[O-])cn2)CC1>>CNC(=O)OC(C)(C)C,[Pd],CCOC(C)=O,,[H][H],,val
US20090181963A1,COC(Cn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21)OC>>O=CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21,,C1COCCO1,Cl,,,val
US20100048623A1,C=C(C)C#C[C@H](CCC(C)C)N1CC[C@@H](CC(=O)OC)C[C@H]1c1ccc(C(F)(F)F)cc1>>COC(=O)C[C@@H]1CCN(C(CCC(C)C)CCC(C)C)[C@H](c2ccc(C(F)(F)F)cc2)C1,[Ni],CO,,,,val
US20090192138A1,CC#CCn1c(N2CCCN(C(=O)OC(C)(C)C)CC2)c(C(=O)N(C)C)c2c1c(=O)n(C)c(=O)n2C>>CC#CCn1c(N2CCCNCC2)c(C(=O)N(C)C)c2c1c(=O)n(C)c(=O)n2C,,ClCCl,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],,val
US06071903,COC(=O)C(CO)N(Cc1cc(C)ccc1[N+](=O)[O-])S(=O)(=O)c1ccc(OC)cc1>>COC(=O)C(CO)N(Cc1cc(C)ccc1N)S(=O)(=O)c1ccc(OC)cc1,[Pd],CCO,CCOC(C)=O,[H][H],,val
US05942509,Cc1ccccc1S.Clc1nnc(Cl)c(Cl)n1>>Cc1ccccc1Sc1nnc(Cl)c(Cl)n1,,C1CCOC1,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20110130380A1,CC(C)(C)OC(=O)N1CCC[C@@H](C(=O)Nc2cc(-c3cncc(NCC4CCOCC4)c3)c(Cl)cn2)C1>>O=C(Nc1cc(-c2cncc(NCC3CCOCC3)c2)c(Cl)cn1)[C@@H]1CCCNC1,,C1COCCO1,CO,Cl,,val
US05210211,CCCc1nc(-n2cccc2)c(C(=O)OC)[nH]1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCCc1nc(-n2cccc2C(=O)C(F)(F)F)c(C(=O)OC)[nH]1,,ClCCl,,O=C([O-])O.[Na+],,val
US20100093748A1,CC(C)(C)OC(=O)NC1(C(=O)O)CCN(C(=O)OC(C)(C)C)CC1.Nc1ccccc1O>>CC(C)(C)OC(=O)NC1(C(=O)Nc2ccccc2O)CCN(C(=O)OC(C)(C)C)CC1,,CC(=O)O,,,,val
US20030065176A1,CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(N[C@@H](Cc2cccc(C#N)c2)C(=O)NC(=O)OC(C)(C)C)cc1.CS(=O)(=O)Cl>>CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(N[C@@H](Cc2cccc(C#N)c2)C(=O)NS(C)(=O)=O)cc1,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,,val
US04495190,BrCCC1CCOCO1.Nc1nc(Cl)c2[nH]cnc2n1>>Nc1nc(Cl)c2ncn(CC3CCOCO3)c2n1,,CCO,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20160007600A1,CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1N.O=C(O)C=CC=Cc1ccccc1>>CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(=O)/C=C/C=C/c1ccccc1,CN(C)c1ccncc1,C1CCOC1,CN(C)C=O,CCN=C=NCCCN(C)C,,val
US20160152605A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1(C)CCNCC1>>CC1(C)CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US20140080810A1,CC[C@H]1CCc2c(Cl)ncnc2C1.CN(C(=O)O)c1nc2ncc(-c3ccc4c(c3)CNCCO4)cc2[nH]1>>CC[C@H]1CCc2c(ncnc2N2CCOc3ccc(-c4cnc5nc(N)[nH]c5c4)cc3C2)C1,,CN1CCCC1=O,CO,CCN(C(C)C)C(C)C,Cl,val
US04367238,CCCCCCl.CCOC(=O)C(C#N)c1cccc(Oc2ccccc2C)c1OC>>CCCCCC(C#N)(C(=O)OCC)c1cccc(Oc2ccccc2C)c1OC,,CN(C)C=O,,[H-].[Na+],,val
US20130225552A1,CCOC(=O)/C=C/c1ccc(OC)cc1[N+](=O)[O-]>>COc1ccc2ccc(=O)[nH]c2c1,[Fe],CC(=O)O,,,,val
US20140171408A1,N#Cc1cc(Cl)c(C(Cl)=Nc2c(F)cncc2F)c(Cl)c1.NC(N)=S>>N#Cc1cc(Cl)c(-c2nc3c(F)cncc3s2)c(Cl)c1,,CC(C)O,,CCN(CC)CC,c1ccncc1,val
US04002647,CCOC(=O)C=C(C)C=CCC(C)(C)C>>CC(C=CCC(C)(C)C)=CCO,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20130261125A1,CC(C)(C)OC(=O)NC1CCCC(=NCc2ccccc2)C1.Fc1ccccc1C[Mg]Cl>>CC(C)(C)OC(=O)NC1CCCC(Cc2ccccc2F)(NCc2ccccc2)C1,,C1CCOC1,,CCOCC,O,val
US20030232853A1,COC(=O)c1ccc2cc(C=O)oc2c1.C[Mg]Br>>COC(=O)c1ccc2cc(C(C)O)oc2c1,,C1CCOC1,,,,val
US20030073839A1,CN(C)C=O.ClCCCC1CCCCC1.NCC=O.O>>COC(CNCCCC1CCCCC1)OC,,O,,[I-].[K+],O=C([O-])O.[Na+],val
US20140303127A1,CN[C@@H]1CC[C@@H](OC(=O)[C@](O)(c2cccs2)C2CCCC2)CC1.CS(=O)(=O)OCCCn1nnc2cc(C=O)ccc21>>CN(CCCn1nnc2cc(C=O)ccc21)[C@@H]1CC[C@@H](OC(=O)[C@](O)(c2cccs2)C2CCCC2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,[I-].[Na+],val
US20130259830A1,CCOC(=O)Cn1c(C)c(Cc2cccnc2S(=O)(=O)c2ccc(F)cc2)c2c1CC(C)(C)CC2=O>>Cc1c(Cc2cccnc2S(=O)(=O)c2ccc(F)cc2)c2c(n1CC(=O)O)CC(C)(C)CC2=O,,C1CCOC1,O,[Na+].[OH-],,val
US20060223798A1,CS(=O)(=O)Cl.NN1CCOCC1>>CS(=O)(=O)NN1CCOCC1,,ClCCl,,CCN(CC)CC,,val
US20090076070A1,CC(C)(Oc1ccc(C(=O)O)cc1C(F)(F)F)C(F)(F)F.NC(=O)Cn1ccc2c(C(N)=NO)cccc21>>CC(C)(Oc1ccc(-c2nc(-c3cccc4c3ccn4CC(N)=O)no2)cc1C(F)(F)F)C(F)(F)F,,C1COCCO1,,CC(C)N=C=NC(C)C,,val
US20150252226A1,Br[Mg]c1ccccc1.O=C1CCc2ccccc21>>C1=CC(c2ccccc2)c2ccccc21,,CCOCC,,Cl,,val
US04657707,C=O.Nc1c(Cl)cc(Cl)c2c1C(=O)c1ccccc1C2=O>>Nc1c(Cl)cc(O)c2c1C(=O)c1ccccc1C2=O,,O,,O=S(=O)(O)O,,val
US20080146605A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C[C@H](N)c1ccccc1>>COC(=O)C[C@H](NC(=O)OC(C)(C)C)c1ccccc1,,C1CCOC1,,[Na+].[OH-],,val
US06908914B1,CCCCCC.CCOCC.Clc1cc(C#CCN2CCCCCC2)ccc1Br.[Li]CCCC>>OC1(c2ccc(C#CCN3CCCCCC3)cc2Cl)C2CC3CC(C2)CC1C3,,CCCCCC,,,,val
US04267190,CC(=Cc1ccc(F)cc1)CN.O=C(Cl)c1ccc(F)cc1>>CC(=Cc1ccc(F)cc1)CNC(=O)c1ccc(F)cc1,,O,,O=C([O-])O.[Na+],,val
US20150057271A1,COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc([N+](=O)[O-])c(F)c2)cc1.C[Si](C)(C)O[Na]>>COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc([N+](=O)[O-])c(O)c2)cc1,,C1CCOC1,,,,val
US05612356,COC(=O)CCC(=O)c1cc(C(C)C)c(O)c(C(C)C)c1.Clc1nnnn1-c1ccccc1>>COC(=O)CCC(=O)c1cc(C(C)C)c(Oc2nnnn2-c2ccccc2)c(C(C)C)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080293708A1,CI.COC(=O)NCCc1c(F)ccc([N+](=O)[O-])c1C(=O)OC>>CN1CCc2c(F)ccc([N+](=O)[O-])c2C1=O,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20140100231A1,C1=COCCC1.COc1nnc(CO)cc1CO[Si](C)(C)C(C)(C)C>>COc1nnc(COC2CCCCO2)cc1CO[Si](C)(C)C(C)(C)C,,CC#N,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20060106020A1,O=P(Cl)(Cl)Cl.On1cnc(-c2cccnc2)c1-c1ccnc(F)c1>>Fc1cc(-c2[nH]c(Cl)nc2-c2cccnc2)ccn1,,ClC(Cl)Cl,,,,val
US20090270412A1,CCOC(CCCNC)OCC.NN(CCC1CCCC1)c1ccc(Cl)cc1>>CNCCc1cn(CCC2CCCC2)c2ccc(Cl)cc12,,CCO,O,Cl,,val
US20090005410A1,CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-n2nnc3ncccc32)cc1>>CC(O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-n2nnc3ncccc32)cc1,,CCOC(C)=O,CO,[BH4-].[Na+],,val
US20110034460A1,O=C1OCCN1Cc1ccc([N+](=O)[O-])cc1F>>Nc1ccc(CN2CCOC2=O)c(F)c1,[Fe],CCO,,CC(=O)O,[Na+].[OH-],val
US20050038104A1,N#Cc1c(C(F)(F)F)ccc(I)c1F.NC(=O)CS>>NC(=O)c1sc2c(I)ccc(C(F)(F)F)c2c1N,,CO,,C[O-].[Na+],,val
US06548499B1,Clc1cc2nc(Cl)c(-c3ccccn3)nc2cc1Cl.NCCCN1CCOCC1>>Clc1cc2nc(NCCCN3CCOCC3)c(-c3ccccn3)nc2cc1Cl,,Cc1ccccc1,,,,val
US20050014794A1,CC(=O)O.CCCC=O.ClCCCl.Nc1ccc([N+](=O)[O-])cc1>>CCCCN(CCCC)c1ccc([N+](=O)[O-])cc1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20050209120A1,CN1CCCNCCN(C)CCCNCC1.[Cl-].[Mn+2].c1ccc([B-](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CN1CCCNCCN(C)CCCNCC1.[Cl-].[Mn+2].c1ccc([B-](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,CO,,[Cl-].[Na+],,val
US20100137588A1,CN(C)[c-]1cccc1I.COc1ccccc1B(O)O.[Fe+2].c1cc[cH-]c1>>COc1ccccc1-c1ccc[c-]1N(C)C.[Fe+2].c1cc[cH-]c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,[Na+].[OH-],,val
US20030073668A1,CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3ncc4ccc(N)nc4n3)cc2)CC1.NC1CCCC1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3ncc4ccc(NC(=O)NC5CCCC5)nc4n3)cc2)CC1,,CN(C)C=O,O,[H-].[Na+],,val
US20140343036A1,CCOC(=O)c1cn(COCC[Si](C)(C)C)c(=O)c2nc(-c3cccc(F)c3)ccc12>>CCOC(=O)c1c[nH]c(=O)c2nc(-c3cccc(F)c3)ccc12,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150209352A1,CC[C@](CO)(CC(N)Cc1ccc(-c2cc(Cl)ccc2F)cc1)C(=O)O.O=C(O)c1c[nH]nn1>>CC[C@](CO)(CC(Cc1ccc(-c2cc(Cl)ccc2F)cc1)NC(=O)c1cnn[nH]1)C(=O)O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140142303A1,O=C1COCCN1c1ccccc1N1CC(CCl)OC1=O.[I-]>>O=C1COCCN1c1ccc(N2CC(CI)OC2=O)cc1,,CC#N,,O,,val
US05302606,COc1ccc(C=O)cc1OC.N#CCc1c[nH]c2ccccc12>>COc1ccc(C=C(C#N)c2c[nH]c3ccccc23)cc1OC,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US05262565,CI.Oc1cccc2cccc(Cc3ccccc3)c12>>COc1cccc2cccc(Cc3ccccc3)c12,,CN(C)C=O,,[H-].[Na+],,val
US20150353553A1,C=O.COC(=O)c1nc(N[C@H](C)C2CCC2)c2c(n1)nc(C1CCCCN1)n2Cc1ccc(C(F)(F)F)cc1>>COC(=O)c1nc(N[C@H](C)C2CCC2)c2c(n1)nc(C1CCCCN1C)n2Cc1ccc(C(F)(F)F)cc1,,CC#N,,CC(=O)O,[BH3-]C#N.[Na+],val
US20060148800A1,CC1(C)NC(=O)c2c(N(Cc3ccccc3)Cc3ccccc3)cccc21.FCCBr>>CC1(C)c2cccc(N(Cc3ccccc3)Cc3ccccc3)c2C(=O)N1CCF,,CCOC(C)=O,,[H-].[Na+],,val
US20070249620A1,CCI.Cc1ccc(O)c([N+](=O)[O-])c1>>CCOc1ccc(C)cc1[N+](=O)[O-],,CC(=O)N(C)C,CCOC(C)=O,[H-].[Na+],,val
US20030069297A1,Cc1[nH]c(C=O)c(C)c1C(=O)N1CCN(C)CC1.O=C1Cc2c(cccc2-c2ccc(OC(F)(F)F)cc2)N1>>Cc1[nH]c(C=C2C(=O)Nc3cccc(-c4ccc(OC(F)(F)F)cc4)c32)c(C)c1C(=O)N1CCN(C)CC1,C1CCNCC1,CCO,,,,val
US20080004323A1,BrCC1CCCCC1.C#C[Si](C)(C)C.S=C=Nc1ccc(Cl)cc1>>C[Si](C)(C)C#CC(=Nc1ccc(Cl)cc1)SCC1CCCCC1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US04242507,O=S(=O)(Cl)c1ccccc1.On1nnc2ccc(Cl)cc21>>O=S(=O)(On1nnc2ccc(Cl)cc21)c1ccccc1,,[Na+],[OH-],CCOCC,,val
US20130184320A1,FC(F)(F)C1(c2cc(Cl)cc(Cl)c2)CO1.Nc1ccc(Br)c(Cl)c1>>OC(CNc1ccc(Br)c(Cl)c1)(c1cc(Cl)cc(Cl)c1)C(F)(F)F,,CCO,,,,val
US20100144741A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)[C@H]1CO1.CC(C)(C)c1cccc(C2(N)CCCCC2)c1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)[C@H](O)CNC1(c2cccc(C(C)(C)C)c2)CCCCC1,,CC(C)O,CCOC(C)=O,[Cl-].[Li+],,val
US20110195948A1,CNC.COC(=O)C(=O)Cl.Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12>>CN(C)C(=O)C(=O)Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110028405A1,CC(=O)O.Cc1cccc(Nc2nc(Cl)ncc2F)c1N>>CC(=O)Nc1c(C)cccc1Nc1nc(Cl)ncc1F,,O,,CC(=O)OC(C)=O,,val
US20140256933A1,CC(C)(O)c1nc(N2C[C@H]3CSC(N)=N[C@@]3(c3ccc(C#N)s3)C2)ncc1F.Cl>>CC(C)(O)c1nc(N2C[C@H]3CSC(N)=N[C@@]3(c3ccc(C#N)s3)C2)ncc1F.Cl,,CCOCC,,,,val
US20130267495A1,CN1CCN(c2cncc([N+](=O)[O-])c2N)CC1>>CN1CCN(c2cncc(N)c2N)CC1,[Pd],CO,,,,val
US20060111375A1,COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1O.ClCCBr>>COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1OCCCl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20050080108A1,CCOC(=O)c1c(Cl)c2cc(N)ccc2n1C.O=C(O)c1ccccc1-c1ccc(C(F)(F)F)cc1>>CCOC(=O)c1c(Cl)c2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2n1C,,CN(C)C=O,ClCCl,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20130121994A1,CC(=O)Cl.N#Cc1ccccc1Nc1nc2ccc(-c3ccc(N)cc3)cn2n1>>CC(=O)Nc1ccc(-c2ccc3nc(Nc4ccccc4C#N)nn3c2)cc1,,C1CCOC1,,c1ccncc1,O=C([O-])O.[Na+],val
US06300334B1,CCOC(=O)c1csc2c1c(=O)n(C)c(=O)n2CC(C)C>>CC(C)Cn1c(=O)n(C)c(=O)c2c(C(=O)O)csc21,,C1CCOC1,CO,O,[Na+].[OH-],val
US20140275085A1,Cc1cc([N+](=O)[O-])ncc1Oc1ccnc(Cl)c1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>Cc1cc([N+](=O)[O-])ncc1Oc1ccnc(-c2cnn(C)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20080167307A1,CCCCCCCN(CCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1)C(=S)NC(=O)OCC1c2ccccc2-c2ccccc21>>CCCCCCCN(CCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1)C(N)=S,,CO,,C1CCNCC1,,val
US20070155744A1,CCN(CC)CC.O=C(O)c1cc(OCc2ccccc2)c(OCc2ccccc2)c(C(=O)NCc2ccc(F)cc2)n1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>Cc1nnc(-c2cc(OCc3ccccc3)c(OCc3ccccc3)c(C(=O)NCc3ccc(F)cc3)n2)o1,,ClCCl,,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US20140256706A1,Cc1cc(O)cc(=O)[nH]1.NN>>Cc1cc(NN)cc(=O)[nH]1,,COCCO,,O,,val
US06727277B1,CC(C)(C)[Si](C)(C)Oc1cc(OC=O)cc(Cl)c1O[Si](C)(C)C(C)(C)C>>CC(C)(C)[Si](C)(C)Oc1cc(O)cc(Cl)c1O[Si](C)(C)C(C)(C)C,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20030092767A1,BrCc1ccccc1.CCc1cc2c(OC)cccc2[nH]1>>CCc1cc2c(OC)cccc2n1Cc1ccccc1,,CN(C)C=O,O,[H-].[Na+],,val
US20100249095A1,CC(C)(C)OC(=O)N1CCC2(CCNCC2)C1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCC2(CCN(C(=O)C(F)(F)F)CC2)C1,,CCN(C(C)C)C(C)C,,,,val
US20100120841A1,COC(=O)C(CCc1ccccc1F)C(=O)OC>>O=C(O)CCCc1ccccc1F,,O,,CCO,[Na+].[OH-],val
US07576098B2,CCOc1cc(OC(C)C)c(F)c(C(Nc2ccc(-c3noc(C)n3)cc2)c2nc(Br)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1.OB(O)c1ccccc1C(F)(F)F>>CCOc1cc(OC(C)C)c(F)c(C(Nc2ccc(-c3noc(C)n3)cc2)c2nc(-c3ccccc3C(F)(F)F)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20050107288A1,C[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)OCc2ccccc2)COC(=O)[C@@H]2CCCN2C1=O.Cl>>C[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H]([NH3+])COC(=O)[C@@H]2CCCN2C1=O.[Cl-],[Pd],CO,,,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)O)c2)=C(C)C1=O.Nc1cccnc1>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3cccnc3)c2)=C(C)C1=O,,ClCCl,,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US20070066658A1,CCOC(=O)NCCc1ccc(Oc2ccc(C(C)=O)cc2)cc1.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)NCCc1ccc(Oc2ccc(OC(C)=O)cc2)cc1,,ClC(Cl)Cl,,,,val
US20080312226A1,CC(=O)N1CCc2cc(NC(=O)OCC(Cl)(Cl)Cl)ccc21.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>CC(=O)N1CCc2cc(NC(=O)N3CCN(c4nc(-c5ccccc5)ns4)CC3)ccc21,,O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20130317100A1,CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)O.O=S(Cl)Cl>>CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)Cl,,CCOCC,,,,val
US20090203750A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC[C@@H]1C[C@H]1c1ccccc1Br>>CC(C)(C)OC(=O)NC[C@@H]1C[C@H]1c1ccccc1Br,,CCOCC,,Cl,[Na+].[OH-],val
US20160243100A1,CC(C)(C)OC(=O)N1CCC(C(F)(F)S(=O)(=O)c2cccnc2N)CC1.COC(CCl)OC>>CC(C)(C)OC(=O)N1CCC(C(F)(F)S(=O)(=O)c2cccn3ccnc23)CC1,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20080167303A1,CC(O)CCBr.O=S1(=O)Nc2ccccc2N1c1ccccc1F>>CC(CCBr)N1c2ccccc2N(c2ccccc2F)S1(=O)=O,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110263649A1,O=C1CCC(N2C(=O)c3cccc([N+](=O)[O-])c3C2=O)C(=O)N1>>Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,[Fe],CCO,O,Cl,,val
US20100286115A1,CI.COC(=O)c1cc(OCc2c(-c3ccc(F)cc3)noc2C)n[nH]1>>COC(=O)c1cc(OCc2c(-c3ccc(F)cc3)noc2C)nn1C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140045872A1,Cc1ccncc1-n1ccc2ccc([N+](=O)[O-])cc2c1=O>>Cc1ccncc1-n1ccc2ccc(N)cc2c1=O,[Pd],CO,ClC(Cl)Cl,,,val
US20050267105A1,BrCc1ccccc1.CCOC(=O)c1nc2n(c(=O)c1O)CCOC2(C)C>>CCOC(=O)c1nc2n(c(=O)c1OCc1ccccc1)CCOC2(C)C,,CCOCC,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20160185727A1,C[C@H]1CC[C@H](O)CC1.N#Cc1c(N)cccc1F>>C[C@@H]1CC[C@@H](Oc2cccc(N)c2C#N)CC1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20080021032A1,CC(C)(O)Cn1ccc(N)n1.O=C(O)C(CC1CCOCC1)c1ccc(Cl)c(Cl)c1>>CC(C)(O)Cn1ccc(NC(=O)C(CC2CCOCC2)c2ccc(Cl)c(Cl)c2)n1,,ClCCl,,Cc1cccc(C)n1,O=C(Cl)C(=O)Cl,val
US20030212095A1,CCn1nnc(N2CC3CNCC(C3)C2)n1.N#Cc1ccc(OCC2CO2)cc1>>CCn1nnc(N2CC3CC(CN(CC(O)COc4ccc(C#N)cc4)C3)C2)n1,,CC(C)O,,O,,val
US05316996,CC(C)c1ccccc1.c1ccccc1>>C=CC.CC(C)c1ccccc1,,c1ccccc1,,[H][H],,val
US06136810,CCNc1nc(CC)ccc1C(=O)c1cccc(Cl)c1.O=C=NS(=O)(=O)Cl>>CCc1ccc2c(-c3cccc(Cl)c3)nc(=O)n(CC)c2n1,,C1CCOC1,O,[Na+].[OH-],,val
US20100210704A1,CC(=O)Nc1cc(OC(F)(F)C(F)F)nn1-c1cc(SCC(F)(F)F)c(C)cc1F.O=C(OO)c1cccc(Cl)c1>>CC(=O)Nc1cc(OC(F)(F)C(F)F)nn1-c1cc(S(=O)CC(F)(F)F)c(C)cc1F,,ClC(Cl)Cl,,,,val
US04880808,CC1CN(Cc2ccccc2)CCN1.CCOC(=O)Cl>>CCOC(=O)N1CCN(Cc2ccccc2)CC1C,,O,,C1CCOC1,[Na+].[OH-],val
US20100158818A1,CC(C)(C)OCl.CC(C)(N)CC[N+]12CCC(CC1)CC2.CS(=O)(=O)[O-].Cl>>CC(C)(CC[N+]12CCC(CC1)CC2)N(Cl)Cl.CS(=O)(=O)[O-],,CO,,O,,val
US20120258946A1,CI.COC(=O)C(C(=O)OC)c1ccc([N+](=O)[O-])cc1F>>COC(=O)C(C)(C(=O)OC)c1ccc([N+](=O)[O-])cc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120309773A1,COC(=O)c1occc1N.O=C=NS(=O)(=O)Cl>>COC(=O)c1occc1NC(N)=O,,ClCCl,O,CC(=O)O,O=C([O-])O.[Na+],val
US20140371199A1,COc1cc(-c2cn3c(-c4ccc(C#N)cc4)cnc3cn2)ccc1C(=O)N1CCN(C(=O)OC(C)(C)C)CC1>>COc1cc(-c2cn3c(-c4ccc(C#N)cc4)cnc3cn2)ccc1C(=O)N1CCNCC1,,C1COCCO1,Cl,,,val
US20130203727A1,COC(=O)C(OC(C)(C)C)c1c(C)c(Br)c2ccccc2c1-c1ccc(Cl)cc1.N#C[Cu]>>Cc1c(C(OC(C)(C)C)C(=O)O)c(-c2ccc(Cl)cc2)c2ccccc2c1C#N,,CCO,,CN1CCCC1=O,,val
US20130019348A1,COC(=O)c1ccc(C(=O)/C=C/N(C)C)cc1.NN>>COC(=O)c1ccc(-c2cc[nH]n2)cc1,,CCO,,O,,val
US05206233,CCC(=O)OC(=O)CC.COc1ccc(C2CCNCCS2)cc1>>CCC(=O)N1CCSC(c2ccc(OC)cc2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20100311966A1,CCc1[nH]c(C(=O)N[C@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2OC)nc1Cl.S=C(n1ccnc1)n1ccnc1>>CCc1[nH]c(C(=O)N[C@H]2CCN(C(=S)n3ccnc3)C[C@H]2OC)nc1Cl,,CO,,CCOC(C)=O,Cl,val
US06521643B1,CC(=O)N(C)C.COc1ccnc(C)c1OC>>COc1ccnc(CC(C)=O)c1OC,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20140187545A1,CCOC(=O)CC(=O)c1ccncc1.Cn1nc(N)c(Cc2cccc(Cl)c2Cl)c1O>>Cn1c(=O)c(Cc2cccc(Cl)c2Cl)c2nc(-c3ccncc3)cc(O)n21,,CC(=O)O,,,,val
US20090197878A1,CC/C(=C\C(N)=O)c1ccc2c(c1)C(C)(C)OC(=O)N2>>CC/C(=C\C#N)c1ccc2c(c1)C(C)(C)OC(=O)N2,,C1COCCO1,,O=S(Cl)Cl,,val
US20120059028A1,CCCC(CC(C)=O)C(=O)OCC.Cc1ccc(C(=O)c2c(N)sc3c2CCN(C)C3)cc1>>CCCC(C(=O)OCC)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCN(C)C3,,CN(C)C=O,,C[Si](C)(C)Cl,,val
US20120115844A1,CC(C)N.Cn1nnc(-c2ccc(F)cc2)c1C#Cc1ccc(C(=O)O)cn1>>CC(C)NC(=O)c1ccc(C#Cc2c(-c3ccc(F)cc3)nnn2C)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US05194614,COc1ccc2cccc(CC(=O)Cl)c2c1.N>>COc1ccc2cccc(CC(N)=O)c2c1,,CCOCC,,,,val
US20080200460A1,CC(C)(C)OC(=O)N1CCN(CC(=O)O)CC1.CS(=O)(=O)N1CCC([C@@H](CCN2CCC(NCC3CC3)CC2)c2cc(F)cc(F)c2)CC1>>CC(C)(C)OC(=O)N1CCN(CC(=O)N(CC2CC2)C2CCN(CC[C@@H](c3cc(F)cc(F)c3)C3CCN(S(C)(=O)=O)CC3)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150025093A1,CCc1cc2c(N3CCC(NC(=O)OC(C)(C)C)CC3)ncnc2s1.Cl.ClCCl>>CCc1cc2c(N3CCC(N)CC3)ncnc2s1.Cl.Cl,,ClCCl,,,,val
US20050171125A1,COCCOc1ccnc(NCc2ccccc2)c1[N+](=O)[O-]>>COCCOc1ccnc(N)c1N,[Pd],CO,Cl,,,val
US20050085555A1,CCOC(=O)C(NC(=O)CCc1ccc(CO)cc1)C(=O)OCC.O=S(Cl)Cl>>CCOC(=O)C(NC(=O)CCc1ccc(CCl)cc1)C(=O)OCC,,ClCCl,,,,val
US20140018361A1,O=C1CCCC1c1c(O)ncnc1O.O=P(Cl)(Cl)Cl>>Clc1ncnc2oc3c(c12)CCC3,,C1COCCO1,,O=C([O-])O.[Na+],,val
US05486466,Cc1c(O)cc(O)cc1C(=O)O.N>>Cc1c(O)cc(N)cc1C(=O)O,,N,,[Cl-].[NH4+],,val
US20120277423A1,C=CC(=O)Cl.Fc1cccc2ccccc12>>C=CC(=O)c1ccc2c(F)cccc2c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20030078251A1,CI.O=C(O)C=Cc1cc([N+](=O)[O-])ccc1Cl>>COC(=O)C=Cc1cc([N+](=O)[O-])ccc1Cl,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110065725A1,CCOC(=O)c1nnn(-c2ccc(F)c(Cl)c2)c1C.Cc1cc(N)ccn1>>Cc1cc(NC(=O)c2nnn(-c3ccc(F)c(Cl)c3)c2C)ccn1,,C1COCCO1,,C[Al](C)C,,val
US20120077979A1,CC(C)(C)[Si](C)(C)Cl.Oc1ccc2cccnc2c1>>CC(C)(C)[Si](C)(C)Oc1ccc2cccnc2c1,CN(C)c1ccncc1,ClCCl,O,CCN(CC)CC,[Cl-].[NH4+],val
US20070225271A1,CC(C)(C)OC(=O)NC1CCNCC1.CCOc1cc(C=O)ccc1OC>>CCOc1cc(CN2CCC(NC(=O)OC(C)(C)C)CC2)ccc1OC,,CCO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20100222383A1,CCCI.OCCCCCCO>>CCCOCCCCCCO,,ClCCl,,O,CC(C)(C)[O-].[K+],val
US20150141418A1,O=C(OO)c1cccc(Cl)c1.Oc1ccc(Br)cc1C1C=CCCC1>>OC1CCCc2c1oc1ccc(Br)cc21,,c1ccccc1,,,,val
US05994355,CCOC(CNC(=O)N(N=Cc1ccccc1)c1cc(Cl)c(Cc2ccc(Cl)cc2)c(Cl)c1)OCC>>O=C1NCC=NN1c1cc(Cl)c(Cc2ccc(Cl)cc2)c(Cl)c1,Cl,CC#N,,,,val
US20140315881A1,Cc1ccc(C(N)c2ccccc2)cc1.Cc1noc(C)c1-c1cc2cc(CC(=O)O)ccc2o1>>Cc1ccc(C(NC(=O)Cc2ccc3oc(-c4c(C)noc4C)cc3c2)c2ccccc2)cc1,,CCOC(C)=O,CN(C)C=O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04589910,CNC.O=C=Nc1ccc(Oc2ccc3sncc3c2)c(C(F)(F)F)c1>>CN(C)C(=O)Nc1ccc(Oc2ccc3sncc3c2)c(C(F)(F)F)c1,,CC#N,,,,val
US05656573,COC(=O)c1c(SC)ccc(C#N)c1C.OO>>COC(=O)c1c(SC)ccc(C(N)=O)c1C,,CCO,O,[Na+].[OH-],,val
US20110313002A1,COc1cccc2c1CC1=C(O2)C(=O)N([C@@H](CC2CCCCC2)C(=O)Nc2ccn(C[C@@H]3COC(C)(C)O3)n2)C1>>COc1cccc2c1CC1=C(O2)C(=O)N([C@@H](CC2CCCCC2)C(=O)Nc2ccn(C[C@@H](O)CO)n2)C1,,C1CCOC1,,Cl,,val
US20110053940A1,CC(C)(C)OC(=O)N(Cc1cc(C/C=C/C#N)cc(Cl)c1Cl)C1CC1>>CC(C)(C)OC(=O)N(Cc1cc(CCCC#N)cc(Cl)c1Cl)C1CC1,[Pd],CCOC(C)=O,,,,val
US20100120789A1,CN(Cc1cccs1)C(=O)CSC12CC3CC(CC(C3)C1)C2.O=C(OO)c1cccc(Cl)c1>>CN(Cc1cccs1)C(=O)CS(=O)C12CC3CC(CC(C3)C1)C2,,ClCCl,,,,val
US20140287916A1,CO.ClCCBr.N#CCc1cnc(Cl)cn1>>COc1cnc(C2(C#N)CC2)cn1,,C1CCOC1,,[H-].[Na+],,val
US06329381B1,CC(C)(C)CN.Nc1nc(Cl)nc2c1ncn2Cc1ccccc1>>CC(C)(C)CNc1nc(N)c2ncn(Cc3ccccc3)c2n1,,CCCCO,,[Na+].[OH-],,val
US20150376611A1,CC(C)[Si]1(C(C)C)OC[C@H]2O[C@@H](n3cnc4c(/C=C/c5ccccc5)ncnc43)[C@H](O)[C@@H]2O[Si](C(C)C)(C(C)C)O1.CI>>CO[C@@H]1[C@@H]2O[Si](C(C)C)(C(C)C)O[Si](C(C)C)(C(C)C)OC[C@H]2O[C@H]1n1cnc2c(/C=C/c3ccccc3)ncnc21,,CN(C)C=O,,O,[H-].[Na+],val
US20100087418A1,CC(C)(C)OC(=O)N1CCOc2c(Br)cccc2C1.OB(O)C1CC1>>CC(C)(C)OC(=O)N1CCOc2c(cccc2C2CC2)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US20060167012A1,Cc1cc([N+](=O)[O-])ccc1OC(F)F>>Cc1cc(N)ccc1OC(F)F,[Fe],CCO,O,CC(=O)O,,val
US20150210690A1,CC(=O)Cl.N[C@H](C[C@@H](Cc1ccc(-c2ccccc2F)cc1)NC(=O)c1c[nH]nn1)C(=O)O>>CC(=O)N[C@H](C[C@@H](Cc1ccc(-c2ccccc2F)cc1)NC(=O)c1c[nH]nn1)C(=O)O,,ClCCl,,CCN(C(C)C)C(C)C,[Na+].[OH-],val
US20070167452A1,CC(=O)OC[C@H](CCC1CO1)COS(=O)(=O)c1ccc(C)cc1>>Cc1ccc(S(=O)(=O)OC[C@H](CO)CCC2CO2)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150080549A1,C=CCOC(=O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.CC(C)(OC(=N)C(Cl)(Cl)Cl)c1ccccc1>>C=CCOC(=O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)OC(C)(C)c1ccccc1,,ClCCl,,,,val
US05405828,CC(=O)OC1COCC1OC(=O)COc1cc(NC(=S)N2CCCCN2)c(F)cc1Cl.S=C(Cl)Cl>>CC(=O)OC1COCC1OC(=O)COc1cc(N=c2sc(=S)n3n2CCCC3)c(F)cc1Cl,,ClCCl,,c1ccncc1,,val
US20090275590A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=c1cc(O)cnn1C1CCCCO1>>O=c1cc(OS(=O)(=O)C(F)(F)F)cnn1C1CCCCO1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20040067960A1,CC1(C)CC(=O)Nc2c(CCN3CCN(c4nsc5ccccc45)CC3)cccc21>>CC1(C)CCNc2c(CCN3CCN(c4nsc5ccccc45)CC3)cccc21,,Cc1ccccc1,,,,val
US06077859,N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1C1C=CCCCC1>>N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)cc1C1C=CCCCC1,,C1CCOC1,,CC(C)(C)ON=O,,val
US20130079328A1,CC(=O)N1CCN(c2ccc(C(=O)O)nc2)CC1.NCc1cnc(-c2ccnc(C(F)(F)F)c2)c(F)c1>>CC(=O)N1CCN(c2ccc(C(=O)NCc3cnc(-c4ccnc(C(F)(F)F)c4)c(F)c3)nc2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US07678800B2,CC(C)(C)OC(=O)N1CCN(c2ccccc2Sc2cn(C(=O)OC(C)(C)C)c3ccccc23)CC1>>c1ccc(N2CCNCC2)c(Sc2c[nH]c3ccccc23)c1,,CCOC(C)=O,,Cl,,val
US20090176775A1,FC(F)=C1CCNc2ccccc21.O=C(Cl)Cl.c1cncc(C2CCNC2)c1>>O=C(N1CCC(c2cccnc2)C1)N1CCC(=C(F)F)c2ccccc21,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US04786310,C=CCn1c(=O)sc2cc(F)c(NC(=O)N3CCCCN3C(=O)OCC)cc21>>C=CCn1c(=O)sc2cc(F)c(-n3c(=O)n4n(c3=O)CCCC4)cc21,,O,,C[O-].[Na+],,val
US20140288045A1,NCCOc1ccnc(Oc2cc(Cl)c(Cl)cc2I)c1.O=S(=O)(Cl)CCCl>>C=CS(=O)(=O)NCCOc1ccnc(Oc2cc(Cl)c(Cl)cc2I)c1,,ClCCl,,CCN(CC)CC,,val
US20080255144A1,CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3-c3ccccc3)CC2)c(F)c1.CON>>CO/N=C(\C)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3-c3ccccc3)CC2)c(F)c1,,CO,c1ccncc1,Cl,,val
US20130190330A1,BrC(Br)(Br)Br.COC(=O)c1cc(CO)cc(-c2ccccc2Cl)c1>>COC(=O)c1cc(CBr)cc(-c2ccccc2Cl)c1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20110212937A1,CNC.Fc1ccc(C2CCc3c(Cl)nc(Cl)nc32)cc1>>CN(C)c1nc(Cl)nc2c1CCC2c1ccc(F)cc1,,CO,,,,val
US05539112,Cc1c(F)c(NC(=O)C(C)(C)C)c2c(=O)cc(-c3ccc(NC(=O)C(C)(C)C)c(Cl)c3)oc2c1F>>Cc1c(F)c(N)c2c(=O)cc(-c3ccc(N)c(Cl)c3)oc2c1F,,O=S(=O)(O)O,,,,val
US04859460,C=CC(=O)N(C)C.C=CC(=O)NCNC(=O)CCl>>C=CC(=O)N(C)C.C=CC(=O)NCNC(=O)CCl,,CO,,OO,,val
US20060058264A1,COC(=O)[C@@H]1C[C@H](N=[N+]=[N-])C(=O)[C@@H]2[C@@]3(C)C[C@@H](c4ccoc4)OC(=O)[C@@H]3CC[C@]21C>>COC(=O)[C@@H]1C[C@H](N)C(=O)[C@@H]2[C@@]3(C)C[C@@H](c4ccoc4)OC(=O)[C@@H]3CC[C@]21C,[Zn],CO,ClCCl,[Cl-].[NH4+],,val
US04208424,CCOC(=O)C(Br)CBr.Oc1ccc(-c2ccccc2)cc1O>>CCOC(=O)C1COc2cc(-c3ccccc3)ccc2O1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150239884A1,C=CCNC(=O)c1nc(SC)ncc1Br>>CSc1ncc2c(C)c[nH]c(=O)c2n1,,CC(=O)N(C)C,ClCCl,CCN(C(C)C)C(C)C,,val
US04851418,CC(NC(=O)OC(C)(C)C)C(=O)NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C1.Cl>>CC(N)C(=O)NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C1.Cl,,CCO,,,,val
US20070043087A1,CC(C)c1ccccc1OCCC(=O)OC(C)(C)C>>CC(C)c1ccccc1OCCC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080161366A1,O=[N+]([O-])c1ccccc1Nc1ccc(F)cc1Cl>>Nc1ccccc1Nc1ccc(F)cc1Cl,[Pd],CCO,,,,val
US20160214971A1,CCS(=O)(=O)NC(=O)c1cc(OC)c(-c2cnc(F)c(Cl)c2)cc1F.Oc1c(F)ccc(F)c1F>>CCS(=O)(=O)NC(=O)c1ccc(-c2cnc(Oc3c(F)ccc(F)c3F)c(Cl)c2)c(OC)c1,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090181941A1,COC(=O)CNCc1cccc(-c2cncc(-c3cc(-c4cccc(C)n4)nc4[nH]ccc34)c2)c1>>Cc1cccc(-c2cc(-c3cncc(-c4cccc(CNCCO)c4)c3)c3cc[nH]c3n2)n1,,C1CCOC1,,[H-].[Na+],,val
US20090023740A1,CC(C)(C)NN.N#CCC(=O)Cc1ccc(Cl)cc1>>CC(C)(C)n1nc(Cc2ccc(Cl)cc2)cc1N,,CCO,,CCN(CC)CC,Cl,val
US20150119385A1,CN(C)CCN.COC(OC)c1nc2c(cc1C=O)CCCN2>>COC(OC)c1nc2c(cc1CNCCN(C)C)CCCN2,,ClCCl,,CC(=O)O,,val
US05225431,CNC(=O)c1cccc(CN2C(=O)NC(Cc3ccc4[nH]cc(CCN(C)Cc5ccccc5)c4c3)C2=O)c1>>CNCCc1c[nH]c2ccc(CC3NC(=O)N(Cc4cccc(C(=O)NC)c4)C3=O)cc12,[Pd],CCO,,,,val
US07214824B2,COc1ccc2c(c1)CCC2(C)C>>CC1(C)CCc2cc(O)ccc21,,ClCCl,,BrB(Br)Br,,val
US20090118273A1,CCN1CCN(Cc2ccc(N)cc2C(F)(F)F)CC1.Cc1ccc(C(=O)Cl)cc1[N+](=O)[O-]>>CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c([N+](=O)[O-])c3)cc2C(F)(F)F)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04987132,COC(=O)C(C)(C)c1ccccc1>>CC(C)(CO)c1ccccc1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20160096839A1,C=CC[C@H](NC(=O)OC(C)(C)C)c1cccc(B2OCC(C)(C)CO2)c1.Nc1cc(Cl)cnc1Br>>C=CC[C@H](NC(=O)OC(C)(C)C)c1cccc(-c2ncc(Cl)cc2N)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US04672121,C1CCNC1.Cc1ccncc1.c1cc(N2CCCC2)ccn1>>CC1CCN(c2ccncc2)CC1,,O,,Cc1ccccc1,,val
US05686482,COC(=O)c1ccc(O)cc1O.OC1CCCCC1>>COC(=O)c1ccc(OC2CCCCC2)cc1O,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160214972A1,CC(C)(C)O[C@@H]1C[C@@H](C(=O)O)N(C(=O)OCC2c3ccccc3-c3ccccc32)C1.Cc1ncsc1-c1ccc(CN)c(O)c1>>Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](OC(C)(C)C)CN2C(=O)OCC2c3ccccc3-c3ccccc32)c(O)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100249123A1,COc1ccc(C(=O)Nc2ccc(C(C)(C)CN)cc2)cc1OC.COc1ccccc1C(=O)O>>COc1ccc(C(=O)Nc2ccc(C(C)(C)CNC(=O)c3ccccc3OC)cc2)cc1OC,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US20100297113A1,CI.COc1cc(C)c(OC)c(OC)c1O>>COc1cc(C)c(OC)c(OC)c1OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150025113A1,CC(C)(C)C(=O)OCCl.CCOC(=O)CN1C(=O)C2C3C=C(C(O)(c4ccccc4)c4ccccn4)C(C3=C(c3ccccc3)c3ccccn3)C2C1=O>>CC(C)(C)C(=O)OCN1C(=O)C2C3C=C(C(O)(c4ccccc4)c4ccccn4)C(C3=C(c3ccccc3)c3ccccn3)C2C1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030134859A1,CCCCCCNc1ccc(-c2ccc(NC(=O)c3cc([N+](=O)[O-])ccc3Cl)cc2)cc1.CI>>CCCCCCN(C)c1ccc(-c2ccc(NC(=O)c3cc([N+](=O)[O-])ccc3Cl)cc2)cc1,,CN(C)C=O,O,[H-].[Na+],,val
US05756508,CC1CN(Cc2ccccc2)CCC1=O.CI>>CC1C[N+](C)(Cc2ccccc2)CCC1=O.[I-],,CC(C)=O,,,,val
US20100029753A1,COC(=O)c1sccc1N.O=S(=O)(Cl)c1cc(F)c(F)cc1Cl>>COC(=O)c1sccc1NS(=O)(=O)c1cc(F)c(F)cc1Cl,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20060172994A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(Cl)cc2)CC1>>O=C(c1ccc(Cl)cc1)N1CCNCC1,,ClCCl,,C1COCCO1,,val
US20060142265A1,CCOC(=O)c1[nH]c2c(C(F)(F)F)cccc2c1C>>Cc1c(CO)[nH]c2c(C(F)(F)F)cccc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100317659A1,O=C(Cl)C(=O)Cl.O=C(O)C(F)(F)c1ccc(F)cc1>>O=C(Cl)C(F)(F)c1ccc(F)cc1,,ClCCl,,CN(C)C=O,,val
US20150274777A1,C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(O)C(=O)NC1CC1>>C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20110046097A1,C=CC(=O)OC.CS(C)=O.O=C1Cc2ccc(Br)cc2N1>>O=C1CCC2(CC1)C(=O)Nc1cc(Br)ccc12,,CS(C)=O,,O,CC(C)(C)[O-].[K+],val
US20100286148A1,O=C(OCCl)c1ccc(F)c(F)c1.O=c1nc(-c2cc(C(F)(F)F)ccn2)[nH]o1>>O=C(OCn1c(-c2cc(C(F)(F)F)ccn2)noc1=O)c1ccc(F)c(F)c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20150119392A1,CNc1ncc2cc(OS(=O)(=O)C(F)(F)F)c(C)nc2n1.Cc1cc(F)c(N)cc1B1OC(C)(C)C(C)(C)O1>>CNc1ncc2cc(-c3cc(N)c(F)cc3C)c(C)nc2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])O.[Na+],,val
US05110977,CN(CCOC(=O)C1CCCCC1)CCOC(=O)C1CCCCC1.ClCc1ccccc1>>C[N+](CCOC(=O)C1CCCCC1)(CCOC(=O)C1CCCCC1)Cc1ccccc1.[Cl-],,CC#N,,,,val
US20130267712A1,O=C(Nc1ccc([N+](=O)[O-])cc1[N+](=O)[O-])c1ccccc1.c1ccccc1>>O=C(c1ccccc1)c1ccccc1,,c1ccccc1,,ClCCl,,val
US03992544,CC(=O)OCc1c2c(n(Cc3ccccc3)c1-c1ccccc1)C(C)CN(Cc1ccccc1)C2>>COCc1c2c(n(Cc3ccccc3)c1-c1ccccc1)C(C)CN(Cc1ccccc1)C2,,CO,,,,val
US20150191452A1,NCc1ccc(C(F)(F)F)cc1.O=C(Cl)C(Br)CCBr>>O=C(NCc1ccc(C(F)(F)F)cc1)C(Br)CCBr,,CCOCC,O,,,val
US04465783,CCCCOC(=O)c1ccccc1.[Cl-].[Cl-].[Cl-].[Ti+3]>>CCCCOC(=O)c1ccccc1.[Cl-].[Cl-].[Cl-].[Ti+3],,Cc1ccccc1,,,,val
US20130059832A1,Cc1ccc(C(=O)[O-])cc1NC(=O)c1cnc2ccccn12>>Cc1ccc(C(=O)O)cc1NC(=O)c1cnc2ccccn12,,C1CCOC1,CO,O,[Li+].[OH-],val
US05843937,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1cc2cc([N+](=O)[O-])ccc2[nH]1>>CCOC(=O)c1cc2cc(NC(=O)OC(C)(C)C)ccc2[nH]1,[Pd],CCOC(C)=O,,,,val
US05081274,CC(=O)OC(C)=O.Oc1c(Br)cccc1Br>>CC(=O)c1cc(Br)c(O)c(Br)c1,O=S(=O)(O)O,,,Cl,,val
US06001835,CCOC(=O)C1CCCN(c2ccccc2)C1=O>>O=C(O)C1CCCN(c2ccccc2)C1=O,,CO,,[Na+].[OH-],,val
US20120238569A1,COC(=O)[C@H](CNC(=O)OC(C)(C)C)NC(=O)c1sc(C(=O)NCc2ccc(F)c(O)c2)cc1C.O=C(O)C(F)(F)F>>COC(=O)[C@H](CN)NC(=O)c1sc(C(=O)NCc2ccc(F)c(O)c2)cc1C.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20060135578A1,CCOC(=O)c1ccc(-c2nc(CCl)c(C)o2)s1.COc1cc(C=O)ccc1O>>CCOC(=O)c1ccc(-c2nc(COc3ccc(C=O)cc3OC)c(C)o2)s1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150011528A1,CCOC(=O)C(CC)n1c(=NC(=O)c2ccc(C)cc2)sc2cc(C)ccc21>>CCC(C(=O)O)n1c(=NC(=O)c2ccc(C)cc2)sc2cc(C)ccc21,,CO,,C1CCOC1,[Na+].[OH-],val
US20120263670A1,CN(CC(=O)c1cccc([N+](=O)[O-])c1)Cc1ccc(Cl)cc1Cl>>CN(Cc1ccc(Cl)cc1Cl)CC(O)c1cccc([N+](=O)[O-])c1,,CO,,[BH4-].[Na+],,val
US20120238541A1,CI.O=c1c(I)c(-c2ccccc2)oc2c1ccn1c(=O)[nH]nc21>>Cn1nc2c3oc(-c4ccccc4)c(I)c(=O)c3ccn2c1=O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100331400A1,BrCc1ccccc1.CC1(C)OC(=O)c2cc(O)ccc2O1>>CC1(C)OC(=O)c2cc(OCc3ccccc3)ccc2O1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04714702,COc1ccc(NC(=O)c2cc([N+](=O)[O-])ccc2NC(=O)CF)c(C)c1>>COc1ccc(-n2c(CF)nc3ccc([N+](=O)[O-])cc3c2=O)c(C)c1,,CC(=O)O,,CCOCC,FB(F)F,val
US20100252433A1,CCCCc1c[nH]c(/C=C/C(=O)OCC)c1>>CCCCc1c[nH]c(CCC(=O)OCC)c1,[Pd],CCO,,[H][H],,val
US04753960,NO.O=C(c1ccc2c(c1)OCO2)C(F)(F)F>>ON=C(c1ccc2c(c1)OCO2)C(F)(F)F,,CO,O,Cl,CC(=O)[O-].[Na+],val
US20020032208A1,COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1O.ClCCSc1ccncc1>>COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCSc1ccncc1,,CN1CCCC1=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20070287708A1,Cc1c(Nc2c(I)cncc2C#N)cc(Cl)c2[nH]ccc12.OB(O)c1cc2ccccc2o1>>Cc1c(Nc2c(C#N)cncc2-c2cc3ccccc3o2)cc(Cl)c2[nH]ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,CCOC(C)=O,,val
US20060009453A1,CC(C)(C)OC(=O)N1CCC[C@H]1COc1cc([N+](=O)[O-])cc(C(F)(F)F)c1>>CC(C)(C)OC(=O)N1CCC[C@H]1COc1cc(N)cc(C(F)(F)F)c1,[Pd],CCO,,,,val
US20020094987A1,BrBr.CCc1nc2c(OC)cccc2o1>>CCc1nc2c(OC)ccc(Br)c2o1,,CO,,,,val
US20100087427A1,CC(C)(C)OC(=O)N1C[C@@H](Cc2ccccc2)[C@H](CNc2ccc(Cl)cc2)C1.COCCCOc1cc(CBr)ccc1OC>>COCCCOc1cc(CN(C[C@@H]2CNC[C@H]2Cc2ccccc2)c2ccc(Cl)cc2)ccc1OC,,CN(C)C=O,,CCN(CC)CC,,val
US20070219198A1,Fc1cccnc1Cl.O=S(=O)(c1ccc(Cl)cc1)C1CCNCC1>>O=S(=O)(c1ccc(Cl)cc1)C1CCN(c2ncccc2F)CC1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20160207930A1,CC(C)(C)OC(=O)N1CCN2C(=O)CC[C@H]2C1=O.Cc1cscc1Br>>Cc1cscc1C(=O)[C@@H]1CCC(=O)N1CCNC(=O)OC(C)(C)C,,C1CCOC1,,[Li]CCCC,,val
US20030153752A1,N#Cc1c(F)cccc1NCCCn1ccnc1.Nc1ncnc2c1c(-c1ccccc1O)cn2C1CCOC1>>N#Cc1c(NCCCn2ccnc2)cccc1Oc1ccc(-c2cn(C3CCOC3)c3ncnc(N)c23)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090093524A1,COC(=O)c1cccc(C=Cc2ccc(OCc3c(C(C)C)nnn3-c3c(Cl)cccc3Cl)cc2Cl)c1>>CC(C)c1nnn(-c2c(Cl)cccc2Cl)c1COc1ccc(C=Cc2cccc(C(=O)O)c2)c(Cl)c1,,CO,,[Na+].[OH-],,val
US20150299179A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.[N-]=[N+]=N[C@@H]1CCCc2c(Br)cccc21>>CC(C)(C)OC(=O)N[C@@H]1CCCc2c(Br)cccc21,O=[Pt]=O,CCOC(C)=O,,,,val
US20090048241A1,N#Cc1ccc(I)cc1.O=Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>N#Cc1ccc(C(O)c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US09040693B2,CC(C)(O)c1ccccc1.O=[N+]([O-])c1cc(O)ccc1Cl>>CC(C)(Oc1ccc(Cl)c([N+](=O)[O-])c1)c1ccccc1,,C1CCOC1,CCOCC,CCCCP(CCCC)CCCC,,val
US20150038481A1,CCCCN.OC1CCC(Nc2nc(Cl)ncc2Br)CC1>>CCCCNc1ncc(Br)c(N[C@@H]2CC[C@@H](O)CC2)n1,,Cc1ccccc1,,,,val
US04399147,CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@H]2OC(C(Br)CCCC(=O)OC)C[C@@H]21>>CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@@H]2OC(C(Br)CCCC(=O)OC)C[C@@H]21,[Pd],CCO,,[H][H],,val
US03950537,Cc1ccc(N=C=S)c(C)c1.NCCO>>Cc1ccc(NC(=S)NCCO)c(C)c1,,CC(C)=O,,,,val
US05585515,C1=CCCCC1.O=C(O)C(F)(F)F>>O=C(OC1CCCCC1)C(F)(F)F,[Cu],,,,,val
US20130096113A1,CSc1nc2ccc(Cn3cnc4cc(C)ccc43)cc2s1.O=C(OO)c1cccc(Cl)c1>>Cc1ccc2c(c1)ncn2Cc1ccc2nc(S(C)=O)sc2c1,,CCOC(C)=O,ClCCl,,,val
US20050256123A1,C=COCCON.Cc1c(Nc2ccc(I)cc2F)c(C(=O)O)nn(C)c1=O>>C=COCCONC(=O)c1nn(C)c(=O)c(C)c1Nc1ccc(I)cc1F,,CCOC(C)=O,CN(C)C=O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US05158966,C=CCc1cc(C=O)cc(CC=C)c1O.O=C1CSC(=S)N1>>C=CCc1cc(C=C2SC(=S)NC2=O)cc(CC=C)c1O,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20090023795A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccc3c(cnn3CC=O)c2)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccc3c(cnn3CCO)c2)cc1,,CO,,[BH4-].[Na+],,val
US20080176906A1,CCOC(=O)CP(=O)(OCC)OCC.Cc1c(C#N)c(-c2ccc(C#N)cc2)c(C)n1Cc1ccc(Cl)c(C=O)c1>>CCOC(=O)/C=C/c1cc(Cn2c(C)c(C#N)c(-c3ccc(C#N)cc3)c2C)ccc1Cl,,CC#N,,C1CCC2=NCCCN2CC1,,val
US06051712,CC(C)(C)OC(=O)N1CCC(c2ccc(CO)cc2)C(OCc2ccc3ccccc3c2)C1.O=C(O)c1ccncc1>>CC(C)(C)OC(=O)N1CCC(c2ccc(COC(=O)c3ccncc3)cc2)C(OCc2ccc3ccccc3c2)C1,,CC#N,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20030149019A1,CC(C)(C)OC(=O)N1CCCN(c2ccc(S(=O)(=O)Nc3ccccc3)cc2NS(C)(=O)=O)CC1.Cl>>CS(=O)(=O)Nc1cc(S(=O)(=O)Nc2ccccc2)ccc1N1CCCNCC1.Cl,,CO,,CCOCC,,val
US20040248854A1,N#CCOCCCCN1C(=O)CCC[C@@H]1CCC(=O)Cc1ccccc1>>N#CCOCCCCN1C(=O)CCC[C@@H]1CCC(O)Cc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04742069,CC1=CC(=O)CS(=O)(=O)N1C(C)C.CN>>CNC(C)=CC(=O)CS(=O)(=O)NC(C)C,,CO,,,,val
US20150141402A1,COc1nn(CC(C)O)cc1[N+](=O)[O-]>>COc1nn(CC(C)O)cc1N,[Pd],CO,,,,val
US20080269286A1,CC(C)(C)OC(=O)N1CCC(O)(c2ccc(F)c(C(F)(F)F)c2)CC1>>Fc1ccc(C2=CCNCC2)cc1C(F)(F)F,,O=C(O)C(F)(F)F,,,,val
US20150329557A1,CCOC(=O)OCC.O=C1CCc2cc(Br)ccc21>>CCOC(=O)C1Cc2cc(Br)ccc2C1=O,,C1CCOC1,,[H-].[Na+],,val
US04460580,NCCOc1ccc(O)c(C(N)=O)c1.OC(CBr)c1ccccc1>>NC(=O)c1cc(OCCNCC(O)c2ccccc2)ccc1O,,CCO,,O=C([O-])O.[K+],,val
US20060205759A1,ON=C1CCc2c([nH]c3ccccc23)C1>>NC1CCc2c([nH]c3ccccc23)C1,,CCO,,[Na+].[OH-],,val
US20120171245A1,C1CCNC1.O=C(O)C1CC2CC(Nc3nc(-c4c[nH]c5ncc(F)cc45)ncc3F)C1C2.[N-]=[N+]=NP(=O)(Oc1ccccc1)Oc1ccccc1>>O=C(NC1CC2CC(Nc3nc(-c4c[nH]c5ncc(F)cc45)ncc3F)C1C2)N1CCCC1,,C1CCOC1,,CCN(CC)CC,,val
US20110245205A1,CC(C)(C)[Si](C)(C)OCCBr.Cc1cc(-c2cnc(C3(O)CCNC(=O)CC3)s2)cc(N(C(=O)OC(C)(C)C)c2nccc(C(F)(F)F)n2)c1>>Cc1cc(-c2cnc(C3(OCCO)CCNC(=O)CC3)s2)cc(N(C(=O)OC(C)(C)C)c2nccc(C(F)(F)F)n2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20030199562A1,COc1cc(Br)c(O)c([N+](=O)[O-])c1>>COc1cc(N)c(O)c(Br)c1,[Ni],CCOC(C)=O,,,,val
US20060223760A1,COc1cccc(C2=C(c3cn4c5c(cccc35)CCC4)C(=O)NC2=O)c1>>COc1cccc([C@@H]2C(=O)NC(=O)[C@H]2c2cn3c4c(cccc24)CCC3)c1,,CCOC(C)=O,CO,[Mg],,val
US20140329804A1,N#C[Cu].Nc1ccc(Br)cc1C(=O)O>>N#Cc1ccc(N)c(C(=O)O)c1,,CN1CCCC1=O,O,CCOCC,Cl,val
US05985894,CCCCc1cn(Cc2ccc(-c3ccccc3C(=O)OC)cc2)c2c(Br)cccc2c1=O>>CCCCc1cn(Cc2ccc(-c3ccccc3C(=O)O)cc2)c2c(Br)cccc2c1=O,,CCO,,[Na+].[OH-],,val
US20080139639A1,CC(Br)C(=O)c1ccccc1F.COC(=O)CC#N>>COC(=O)C(C#N)C(C)C(=O)c1ccccc1F,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20060229309A1,CCCNCCC.CCCO[C@@H]1C[C@H]([C@@H](O[Si](C)(C)C(C)(C)C)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(C)cc(C(=O)O)c2)N(C(=O)OC(C)(C)C)C1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl>>CCCO[C@@H]1C[C@H]([C@@H](O[Si](C)(C)C(C)(C)C)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(C)cc(NC(=O)c3ccccc3)c2)N(C(=O)OC(C)(C)C)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060069102A1,CC(C)(C)OC(=O)N1CCC(C=O)CC1.CCOC(=O)[C@@H](N)CS>>CCOC(=O)C1CSC(C2CCN(C(=O)OC(C)(C)C)CC2)=N1,,Cc1ccccc1,,CCN(CC)CC,Cl,val
US20090131458A1,COc1nc2c(N)nc(NCCC3CC3)nc2n1CC1CCCOC1>>Nc1nc(NCCC2CC2)nc2c1[nH]c(=O)n2CC1CCCOC1,,C1COCCO1,CO,Cl,[Na+].[OH-],val
US20120065202A1,COC(=O)Cl.C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NC3CC3)cc2)nc2c1CNC2>>COC(=O)N1Cc2nc(-c3ccc(NC(=O)NC4CC4)cc3)nc(N3CCOC[C@@H]3C)c2C1,,C1COCCO1,,,,val
US20070142438A1,Cc1ccc2c(-c3n[nH]c(=S)n3C)cccc2n1.ClCCCBr>>Cc1ccc2c(-c3nnc(SCCCCl)n3C)cccc2n1,,CCO,,[H-].[Na+],,val
US04487927,C=CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCC(=O)OC)C(=O)CCl)[C@H]2SC1.NC(N)=S>>C=CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCC(=O)OC)c3csc(N)n3)[C@H]2SC1,,O,,Cl,CC(=O)[O-].[Na+],val
US06121307,COc1ccccc1OCCN(CCCc1c[nH]c2ccccc12)Cc1ccccc1>>COc1ccccc1OCCNCCCc1c[nH]c2ccccc12,[Pd],CCO,,,,val
US20070203186A1,COC(=O)c1ccc(Cn2nc(-c3ccc(Cl)c(Cl)c3)cc2C(=O)OC(C)(C)C)nc1>>COC(=O)c1ccc(Cn2nc(-c3ccc(Cl)c(Cl)c3)cc2C(=O)O)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130214249A1,Brc1ccc(I)cc1.CC1(C)OB(c2ccc3c(c2)c2ccccc2n3-c2ccccc2)OC1(C)C>>Ic1ccc(-c2ccc3c(c2)c2ccccc2n3-c2ccccc2)cc1,,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US04868301,CCOC(=O)Cc1nn(CO)c(=O)c2ccccc12.CS(=O)(=O)Cl>>CCOC(=O)Cc1nn(CCl)c(=O)c2ccccc12,,ClCCl,,c1ccncc1,,val
US06313137B1,CCc1cccc(C)c1COC(=O)c1cnc([N+](=O)[O-])c(OCc2c(C)cccc2CC)c1.N>>CCc1cccc(C)c1COc1cc(C(N)=O)cnc1N,,CO,,,,val
US20070281963A1,Nc1cc([N+](=O)[O-])ccc1C(=O)O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=c1[nH]c2cc([N+](=O)[O-])ccc2c(=O)o1,,C1CCOC1,,,,val
US20090227601A1,Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCNCC2(C)C)cc1.O=Cc1ccncc1>>Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCN(Cc3ccncc3)CC2(C)C)cc1,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20060111375A1,CCNCC.COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1OCCCCl>>CCN(CC)CCCOc1cc2nccc(Oc3ccc(C)cc3C(=O)c3ccccc3)c2cc1OC,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150336938A1,CI.O=C1OCc2c1c(-c1ccc3c(c1)OCO3)c1cc3c(cc1c2O)OCO3>>COc1c2c(c(-c3ccc4c(c3)OCO4)c3cc4c(cc13)OCO4)C(=O)OC2,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20110183973A1,CC(=O)N1CCOC(C(=O)O)C1.Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12>>CC(=O)N1CCOC(C(=O)Nc2cc(-c3cccc4[nH]ccc34)cc3[nH]ncc23)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080221175A1,COC(=O)C[C@@H]1CC[C@@H](N(C(=O)c2ccc(Br)cc2F)C2CC2)CC1>>O=C(c1ccc(Br)cc1F)N(C1CC1)[C@@H]1CC[C@@H](CCO)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050075373A1,CCOC(C)=NC(=O)c1cccc(F)c1.NNc1ccc(S(N)(=O)=O)cn1>>Cc1nc(-c2cccc(F)c2)n(-c2ccc(S(N)(=O)=O)cn2)n1,,CO,ClCCl,O,,val
US20050137171A1,c1ccc(Oc2ccc3[nH]nc(-c4cc5ccccc5[nH]4)c3c2)cc1>>Oc1ccc2[nH]nc(-c3cc4ccccc4[nH]3)c2c1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20130210796A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2.FC(F)(F)c1ccc(-n2nnnc2CCl)cc1>>CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2Cc1nnnn1-c1ccc(C(F)(F)F)cc1,,CC#N,,CCN(CC)CC,,val
US20050288304A1,CN1CCN(C2CCCc3ccc(NC(=O)c4ccc(CNC(=O)OC(C)(C)C)cc4)cc32)CC1>>CN1CCN(C2CCCc3ccc(NC(=O)c4ccc(CN)cc4)cc32)CC1,,CCOCC,ClCCl,Cl,,val
US20130018033A1,COc1ccc(CNc2ncnc3c(C(=O)O)cccc23)c(OC)c1.Nc1c(F)ccc(NS(=O)(=O)N2CCCC2)c1F>>COc1ccc(CNc2ncnc3c(C(=O)Nc4c(F)ccc(NS(=O)(=O)N5CCCC5)c4F)cccc23)c(OC)c1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070099990A1,CC(C)(C)[Mg]Cl.CCN(C(=O)C(=O)[O-])c1c(C)c(C)c2c(c1C)C(c1ccc(C(C)C)cc1)CO2>>Cc1c(C)c2c(c(C)c1NC(=O)C(O)C(C)(C)C)C(c1ccc(C(C)C)cc1)CO2,,C1CCOC1,,,,val
US20040006071A1,CCN1c2ncc(CCOc3ccc(C(=O)Cl)cc3C)cc2C(=O)N(C)c2cccnc21.Nc1ccncc1>>CCN1c2ncc(CCOc3ccc(C(=O)Nc4ccncc4)cc3C)cc2C(=O)N(C)c2cccnc21,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20160024016A1,CN(CCN(C)C(=O)OC(C)(C)C)Cc1cn(C2CCCCO2)nc1C1CCC(C)(C)[C@H](OCC2CCOCC2)C1>>CNCCN(C)Cc1c[nH]nc1C1CCC(C)(C)[C@H](OCC2CCOCC2)C1,,C1COCCO1,,Cl,,val
US20100168082A1,CC(C)(C)OC(=O)N1CCC(C(N)=O)C1.CS(=O)(=O)OCc1cc(Oc2ccc3c(ccn3C(=O)Nc3cccc(C(F)(F)F)c3)c2)ncn1>>NC(=O)C1CCN(Cc2cc(Oc3ccc4c(ccn4C(=O)Nc4cccc(C(F)(F)F)c4)c3)ncn2)C1,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20140031368A1,CC(C)(C)OC(=O)C(C(=O)OC(C)(C)C)c1ccc(N)cc1.COC(=O)CCCCCCC(=O)[O-]>>COC(=O)CCCCCCC(=O)Nc1ccc(C(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1,,ClCCl,,CCN=C=NCCCN(C)C,,val
US05994378,CCOC(=O)CCCCOc1ccc2c(c1)c(CC(=O)OC)cn2Cc1ccc2oc(-c3nc(C(C)(C)C)cs3)cc2c1>>CC(C)(C)c1csc(-c2cc3cc(Cn4cc(CC(=O)O)c5cc(OCCCCC(=O)O)ccc54)ccc3o2)n1,,CO,,C1CCOC1,[Na+].[OH-],val
US05191121,CC(=O)C(C)(C)C.COC(=O)c1cc(OC)c(OC)c(OC)c1>>COc1cc(C(=O)CC(=O)C(C)(C)C)cc(OC)c1OC,,C1CCOC1,CCCCCC,Cl,[H-].[Na+],val
US04202832,O=C(O)CCS.S=C=NCc1ccc(Cl)cc1>>O=C(O)CCSC(=S)NCc1ccc(Cl)cc1,,CCN(CC)CC,,Cc1ccccc1,Cl,val
US20080221303A1,CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O>>N[C@@H](CCCCNC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O,,O=C(O)C(F)(F)F,,,,val
US05053426,CCCCCCCC/C=C\CCCCCCCC(=O)O.O=C(Cl)C(=O)Cl>>CCCCCCCC/C=C\CCCCCCCC(=O)Cl,,CCCCCC,,,,val
US20160024056A1,CC1(C)OB(c2cnn(C3CCCCO3)c2)OC1(C)C.O=C(OCc1ccccc1)N1CCC(Cn2ccc3cc(Br)ccc32)CC1>>O=C(OCc1ccccc1)N1CCC(Cn2ccc3cc(-c4ccn(C5CCCCO5)n4)ccc32)CC1,,CN(C)C=O,O,ClCCl,O=C([O-])[O-].[K+].[K+],val
US03983243,CC(=CCOc1ccc2c(c1)OCO2)CCC(C)=C(C)C.O=C(OO)c1cccc(Cl)c1>>CC(=CCOc1ccc2c(c1)OCO2)CCC1(C)OC1(C)C,,ClCCl,,,,val
US20080182842A1,COC(=O)[C@H](Cc1ccc(OCCc2ccc3c(n2)N(C(=O)OC(C)(C)C)CCO3)cc1)NC(=O)OC(C)(C)C>>COC(=O)[C@@H](N)Cc1ccc(OCCc2ccc3c(n2)NCCO3)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US05639752,CN1CCC[C@@H]1Cc1c[nH]c2ccc(N)cc12.Cc1ccnc(Cl)c1[N+](=O)[O-]>>Cc1ccnc(Nc2ccc3[nH]cc(CC4CCCN4C)c3c2)c1[N+](=O)[O-],,CCO,,CCN(CC)CC,,val
US06303606B1,Cc1ccc(C(=O)O)o1.O=S(Cl)Cl>>Cc1ccc(C(=O)Cl)o1,,c1ccccc1,,,,val
US20070287695A1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccsc1C(=O)O.O=C1N[C@H]2CCCC[C@@H]2N1C1CCN(C2CCNCC2)CC1>>COc1ccsc1C(=O)N1CCC(N2CCC(N3C(=O)N(C)[C@H]4CCCC[C@@H]43)CC2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130281434A1,Cc1cc2nc(-c3ccnc(-c4cccc(C#N)c4)c3)sc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C.[N-]=[N+]=[N-]>>Cc1cc2nc(-c3ccnc(-c4cccc(-c5nnn[nH]5)c4)c3)sc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C,,CN(C)C=O,,[Cl-].[NH4+],,val
US20160002175A1,CC(=O)NCCN.Cc1cccc(-c2cc(Cl)nc(N)n2)c1C>>CC(=O)NCCNc1cc(-c2cccc(C)c2C)nc(N)n1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20160264518A1,CCOC(=O)/C=C/c1ccccc1Br.O=C1NCCC1c1ccccc1>>CCOC(=O)/C=C/c1ccccc1N1CCC(c2ccccc2)C1=O,[Cu]I,CN(C)C=O,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20060063785A1,Nc1cccc(-c2ccnc3c(C(=O)c4cccs4)cnn23)c1.O=Cc1ccccc1>>O=C(c1cccs1)c1cnn2c(-c3cccc(NCc4ccccc4)c3)ccnc12,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20150368245A1,CC(C)(C)[Si](C)(C)OC[C@@H]1CC[C@@H](N2CN(C3CC3)C(=O)c3cnc4c(ccn4COCC[Si](C)(C)C)c32)CC1>>C[Si](C)(C)CCOCn1ccc2c3c(cnc21)C(=O)N(C1CC1)CN3[C@@H]1CC[C@@H](CO)CC1,,C1COCCO1,,Cl,O=C([O-])O.[Na+],val
US04794188,CCCCCC(O)c1ccc(O)cc1.ClCc1ccc[nH]1>>CCCCCC(O)c1ccc(OCc2ccc[nH]2)cc1,,CC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20100093730A1,BrC(Br)(Br)Br.CC(C)(C)OC(=O)N1CCN(CCO)CC1>>CC(C)(C)OC(=O)N1CCN(CCBr)CC1,,C1CCOC1,CCCCCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070123512A1,Cl.OCCCc1ccc(O)cc1>>Oc1ccc(CCCCl)cc1,,O,,,,val
US20080021059A1,CCNC(=O)Nc1nc2cc(Br)cc(C(=O)OCC)n2n1.COc1ccc(CN)cc1OC>>CCNC(=O)Nc1nc2cc(Br)cc(C(=O)NCc3ccc(OC)c(OC)c3)n2n1,,CCO,,,,val
US20040082639A1,COc1cc2c(cc1OC)-c1n[nH]c(Nc3cccc(F)c3)c1C2.O=C(Cl)Oc1ccccc1>>COc1cc2c(cc1OC)-c1c(c(Nc3cccc(F)c3)nn1C(=O)Oc1ccccc1)C2,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US06166006,O=[N+]([O-])c1ccc(CCN2CCCCC2)cc1>>Nc1ccc(CCN2CCCCC2)cc1,,CCO,,,,val
US20120283242A1,C1=COCCC1.Cc1cc(Br)cc(Cl)c1Oc1ccc(O)cn1>>Cc1cc(Br)cc(Cl)c1Oc1ccc(OC2CCCCO2)cn1,,C1CCOC1,ClCCl,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20060074111A1,CCCCCNc1cccc(-c2ccc(C(F)(F)F)cc2)c1.CCOC(=O)COc1ccc(CBr)cc1C>>CCCCCN(Cc1ccc(OCC(=O)OCC)c(C)c1)c1cccc(-c2ccc(C(F)(F)F)cc2)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20070197577A1,COC(=O)c1ccc(N=C=S)cc1.NN>>COC(=O)c1ccc(NC(=S)NN)cc1,,Cc1ccccc1,,O,,val
US04497805,COC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](O)C[C@]4(C)[C@H]3[C@H](NCCC(C)C)C[C@]12C.Cl>>COC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](O)C[C@]4(C)[C@H]3[C@H](NCCC(C)C)C[C@]12C.Cl,,O,,,,val
US04772600,CCOC(=O)Cn1c(-c2cccc(Br)c2)nc2cccnc21>>O=C(O)Cn1c(-c2cccc(Br)c2)nc2cccnc21,,O,,CCO,[Na+].[OH-],val
US20060270874A1,NS(=O)(=O)/C=C/c1ccc(Cl)cc1.O=C(Cl)c1ccc(Cl)cc1Cl>>O=C(NS(=O)(=O)/C=C/c1ccc(Cl)cc1)c1ccc(Cl)cc1Cl,,C1COCCO1,,Cl,O=C([O-])[O-].[K+].[K+],val
US05646173,COc1ccc2c(c1)-c1c(ccn1CCNC(C)=O)CC2>>COc1ccc2ccc3ccn(CCNC(C)=O)c3c2c1,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20100261702A1,CCN(CC)Cc1sc(-c2nc(-c3ccc(CCO)cc3)no2)cc1C.CS(=O)(=O)Cl>>CCN(CC)Cc1sc(-c2nc(-c3ccc(CCOS(C)(=O)=O)cc3)no2)cc1C,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,,val
US20070043048A1,Cc1ccc(S(=O)(=O)OCCCc2ccc(-c3ccnc(NC4CC(C)(C)NC(C)(C)C4)n3)cc2)cc1.N>>CC1(C)CC(Nc2nccc(-c3ccc(CCCN)cc3)n2)CC(C)(C)N1,,CO,,,,val
US20130023541A1,CCNCc1ccc(CN2CCN(c3ncccc3C(=O)OC(C)C)CC2)cc1.O=Cc1ccccc1>>CCN(Cc1ccccc1)Cc1ccc(CN2CCN(c3ncccc3C(=O)OC(C)C)CC2)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20100234365A1,Nc1ccc(Oc2ccc(Cl)cc2)cc1.O=C1CCC(=O)O1>>O=C1CCC(=O)N1c1ccc(Oc2ccc(Cl)cc2)cc1,,Cc1ccccc1,,O=S(Cl)Cl,,val
US20140309227A1,C[C@@H](CNC(CI)C(F)(F)F)NC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>C[C@H](N)CNC(CI)C(F)(F)F.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20130150339A1,COc1ccc(CN(c2ncns2)S(=O)(=O)c2ccc3c(Br)cccc3c2)c(OC)c1.N#Cc1cc(C(F)(F)F)ccc1B(O)O>>N#Cc1cc(C(F)(F)F)ccc1-c1cccc2cc(S(=O)(=O)Nc3ncns3)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20040077681A1,Nc1n[nH]c2cnc(-c3cnc4ccccc4c3)cc12.O=C(Cl)C1CC1>>O=C(Nc1n[nH]c2ccc(-c3cnc4ccccc4c3)nc12)C1CC1,,c1ccncc1,,,,val
US20130172315A1,CC(C)(C)OC(=O)NC1CCNC1.C[C@@H](Nc1cc(N2CCC(=O)CC2)ccc1Cl)c1ccc(Cl)cc1Cl>>C[C@@H](Nc1cc(N2CCC(N3CCC(NC(=O)OC(C)(C)C)C3)CC2)ccc1Cl)c1ccc(Cl)cc1Cl,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070191387A1,COC(=O)/C=C/c1cccc(F)c1N=C=Nc1cc(C(F)(F)F)ccc1OC.Cc1cccc(N2CCNCC2)c1>>COC(=O)CC1c2cccc(F)c2N=C(N2CCN(c3cccc(C)c3)CC2)N1c1cc(C(F)(F)F)ccc1OC,,ClCCl,,,,val
US04405623,CCOC(=O)c1c(C)cc(N)c(C(=O)O)c1C.Cl.Cl.ClCCN1CCCCC1>>CCOC(=O)c1c(C)cc(NCCN2CCCCC2)c(C(=O)O)c1C.Cl.Cl,,CCO,O,O=C([O-])O.[Na+],,val
US20020087002A1,COc1ccc(F)cc1COCCCOc1ccc([C@H]2[C@H](OC[C@H]3COC(C)(C)O3)CN(C(=O)OC(C)(C)C)C[C@@H]2OCc2cc(OC)c3ccccc3c2)cc1>>COc1ccc(F)cc1COCCCOc1ccc([C@H]2[C@H](OC[C@H](O)CO)CNC[C@@H]2OCc2cc(OC)c3ccccc3c2)cc1,,CO,,Cl,,val
US05880147,CC(C)(C)c1ccc(/C=C/CO[Si](C)(C)C(C)(C)C)cc1[N+](=O)[O-]>>CC(C)(C)c1ccc(CCCO[Si](C)(C)C(C)(C)C)cc1N,[Pd],CCOCC,,[H][H],,val
US20050192277A1,C[C@@H]1CCCN1CCc1cc2cc(Br)ccc2o1.Fc1cccc(SSc2cccc(F)c2)c1>>C[C@@H]1CCCN1CCc1cc2cc(Sc3cccc(F)c3)ccc2o1,,C1CCOC1,,[Li]C(C)(C)C,,val
US20060293311A1,NC(=O)CBr.O=[N+]([O-])c1ccc(O)cc1>>NC(=O)COc1ccc([N+](=O)[O-])cc1,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US06797706B1,Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)nc(Cl)c2C#N)c1.Oc1ccccc1Cl>>Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)nc(Oc3ccccc3Cl)c2C#N)c1,,CN(C)C=O,,[H-].[Na+],,val
US20100317659A1,O=C(Cl)OCc1ccccc1.O=C1NC(c2ccc(F)cc2)C(=O)O1>>O=C1OC(=O)N(C(=O)OCc2ccccc2)C1c1ccc(F)cc1,,C1CCOC1,,CN1CCOCC1,,val
US20090069297A1,CC1(C)OC(=O)CC(=O)O1.CCOC(OCC)OCC.Nc1ccncc1>>CC1(C)OC(=O)C(=CNc2ccncc2)C(=O)O1,,CCCCCC,,,,val
US20020193407A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.CCc1nn2c(c1Br)CCCC2>>CCc1nn2c(c1C1(O)CCN(C(=O)OC(C)(C)C)CC1)CCCC2,,C1CCOC1,,[Li]C(C)(C)C,,val
US06313114B1,O=[N+]([O-])c1ccc(Cl)cc1O>>Nc1ccc(Cl)cc1O,,CCO,,,,val
US20090209524A1,CCOC(=O)C(Cc1cc(CC(=O)OC)ccc1OC)C(C)=O.N=C(N)N>>COC(=O)Cc1ccc(OC)c(Cc2c(C)nc(N)nc2O)c1,,CO,,O=C(O)O,,val
US04036629,CC(=O)OCCC(C)C1CC=C(C)CC1.O=C(OO)c1cccc(Cl)c1>>CC(=O)OCCC(C)C1CCC2(C)OC2C1,,ClCCl,,,,val
US20160228450A1,COC(=O)CC(=O)Cl.COC(=O)CCNC1CCN(C(=O)OCc2ccccc2)CC1>>COC(=O)CCN(C(=O)CC(=O)OC)C1CCN(C(=O)OCc2ccccc2)CC1,,ClCCl,,,,val
US20050250818A1,Cc1ccccc1CCOc1ccc(Cl)cc1C(=O)NCc1ccc(C(=O)OC(C)(C)C)cc1>>Cc1ccccc1CCOc1ccc(Cl)cc1C(=O)NCc1ccc(C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120077806A1,CCCC(=O)c1ccc(O)cc1.CCN(CC)CCCl>>CCCC(=O)c1ccc(OCCN(CC)CC)cc1,,CC(C)=O,CCOC(C)=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20100261724A1,CI.O=C(O)Cc1ccc(-c2nccnc2Cl)cc1>>COC(=O)Cc1ccc(-c2nccnc2Cl)cc1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20100286088A1,CCOP(=O)(CN=C=O)OCC.[N-]=[N+]=C1N=CN=C1C(N)=O>>CCOP(=O)(Cn1nnc2c(C(N)=O)ncn2c1=O)OCC,,CCOC(C)=O,CS(C)=O,CCOCC,,val
US20080085887A1,Cc1ccc(C)n1-c1scnc1C=O.Nc1ccnc(C(F)(F)F)c1C(=O)NCCc1ccccc1>>Cc1ccc(C)n1-c1scnc1-c1nc2ccnc(C(F)(F)F)c2c(=O)n1CCc1ccccc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05534515,CCOC(=O)c1cc(C)n(Cc2ccccc2)c1C(=O)OCC.NN>>Cc1cc2c(=O)[nH][nH]c(=O)c2n1Cc1ccccc1,,COCCOCCOC,,Cl,O,val
US20130109711A1,O=C1NCCCC12CCCNC2.O=S(=O)(Cl)c1cccc(OC(F)(F)F)c1>>O=C1NCCCC12CCCN(S(=O)(=O)c1cccc(OC(F)(F)F)c1)C2,,ClCCl,,CCN(CC)CC,Cl,val
US20030134854A1,COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(Br)c3)nc12.NC1CCCCC1>>COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(NC4CCCCC4)c3)nc12,,CN1CCCC1=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150352091A1,CC(C)OC(=O)C(C)(NS(=O)C(C)(C)C)c1ccccc1>>CC(NS(=O)C(C)(C)C)(C(=O)O)c1ccccc1,,CCOC(C)=O,CO,[Na+].[OH-],,val
US05597820,CCI.CC[C@@H]1Oc2cc(C(=O)OC)ccc2NC1=O>>CC[C@@H]1Oc2cc(C(=O)OC)ccc2N(CC)C1=O,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20120122905A1,CC1(C)OCC(c2ccc(O)cc2)CO1.Cc1c(Cl)ncnc1OC1CCN(c2nc(C(C)C)no2)CC1>>Cc1c(Oc2ccc(C3COC(C)(C)OC3)cc2)ncnc1OC1CCN(c2nc(C(C)C)no2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110190257A1,CC(C)(C)OC(=O)c1ccc(F)c(C=O)c1Br.NN>>CC(C)(C)OC(=O)c1ccc2[nH]ncc2c1Br,,COCCOC,,O,,val
US20050009829A1,CC(C)N1CCC(NC(=O)c2nc3ccc(C(=O)O)cc3n2Cc2cc(-c3ccc(Cl)s3)on2)CC1.OCCO>>CC(C)N1CCC(NC(=O)c2nc3ccc(C(=O)OCCO)cc3n2Cc2cc(-c3ccc(Cl)s3)on2)CC1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130296377A1,CO.COc1cc(C)c2[nH]ccc2c1C(CC(=O)O)c1nc2cc(C#N)ccc2o1>>COC(=O)CC(c1nc2cc(C#N)ccc2o1)c1c(OC)cc(C)c2[nH]ccc12,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20110166137A1,CNc1nccc(-c2cc(N3CCN(C(=O)OC(C)(C)C)CC3)c3cc(OC)ccc3c2)n1.Cl>>CNc1nccc(-c2cc(N3CCNCC3)c3cc(OC)ccc3c2)n1.Cl,,C1COCCO1,ClCCl,,,val
US20120122817A1,CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2cnc3c(c2)c(=O)c(C(=O)O)cn3[C@H](COP(=O)(O)OCc2ccccc2)CC(C)C)cn1>>CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2cnc3c(c2)c(=O)c(C(=O)O)cn3[C@H](COP(=O)(O)O)CC(C)C)cn1,,ClCCl,,C[Si](C)(C)Br,,val
US20050222140A1,CCOC(=O)C(F)(F)F.N=C(N)c1cccc(I)c1.NN>>FC(F)(F)c1nnc(-c2cccc(I)c2)[nH]1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20030092712A1,COc1cc(-c2ccc(F)cc2F)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)CC2>>O=C1CCc2c(-c3ccc(F)cc3F)cc(O)cc2N1c1c(Cl)cccc1Cl,,ClCCl,,BrB(Br)Br,,val
US20090093483A1,CC(C)(C)OC(=O)CN.CCOC(=O)C1=C(O)c2cc(OC)ccc2C2(CCOCC2)C1=O>>COc1ccc2c(c1)C(O)=C(C(=O)NCC(=O)OC(C)(C)C)C(=O)C21CCOCC1,,C1COCCO1,,CCN(C(C)C)C(C)C,Cl,val
US05543534,CCOC(=O)CBr.CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCC3=O)cc1>>CCOC(=O)CC1(O)CCC(C)(C)c2cc(C#Cc3ccc(C(=O)OCC)cc3)ccc21,[Zn],c1ccccc1,,,,val
US20040110787A1,N#Cc1ncccn1.O.[Na+].[OH-]>>O=C([O-])c1ncccn1.[Na+],,O,,CCO,,val
US20070249670A1,COC(=O)[C@H](CCNC(=O)OC(C)(C)C)NC(=O)c1ccc(F)cc1N.Cc1cc(C)c(N=C=O)c(C)c1>>COC(=O)[C@H](CCNC(=O)OC(C)(C)C)NC(=O)c1ccc(F)cc1NC(=O)Nc1c(C)cc(C)cc1C,,c1ccncc1,,,,val
US20100239576A1,CN(CC(=O)O)C(=O)OCc1ccccc1.COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1>>COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)OC(=O)CN(C)C(=O)OCc5ccccc5)n(-c5ccccc5)c4=O)cc3F)ccnc2c1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US06054470,CCCCCCn1cc(C(=O)OC)c(C)c([N+](=O)[O-])c1=O>>CCCCCCn1cc(C(=O)OC)c(C)c(N)c1=O,[Pd],CCOC(C)=O,,,,val
US20110218192A1,CC(=O)c1cc(Br)ccc1O.CC(C)C1CCC(=O)C1>>CC(C)C1CCC2(CC(=O)c3cc(Br)ccc3O2)C1,,CO,,C1CCNC1,,val
US20080004327A1,BrCc1ccccc1.COC(=O)c1ccc[nH]1>>COC(=O)c1cccn1Cc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20070185133A1,Cc1ccc(S(=O)(=O)OCCCl)cc1.Oc1ccc2sccc2c1>>ClCCOc1ccc2sccc2c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020115874A1,CCC1(O)CC2CCC1C2>>CC=C1CC2CCC1C2,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120232056A1,COC(=O)c1ccc2nc(-c3ccc4[nH]ccc4c3)c(N3CCCCC3)nc2c1>>O=C(O)c1ccc2nc(-c3ccc4[nH]ccc4c3)c(N3CCCCC3)nc2c1,,CO,,O,[Na+].[OH-],val
US20050107364A1,CCCCC1(CCCC)C(=O)C(C2=NS(=O)(=O)c3cc(/C=C/C(N)=O)ccc3N2)=C(O)c2cc(F)ccc21>>CCCCC1(CCCC)C(=O)C(C2=NS(=O)(=O)c3cc(CCC(N)=O)ccc3N2)=C(O)c2cc(F)ccc21,[Pd],CCOC(C)=O,,,,val
US04663341,CC1CNN=C1c1ccc(Cl)cc1.O=C=Nc1ccc(Cl)cc1>>CC1CN(C(=O)Nc2ccc(Cl)cc2)N=C1c1ccc(Cl)cc1,,ClCCl,,,,val
US20080004301A1,Cc1ccc(C(F)(F)F)c(OC(=O)OC(C)(C)C)c1C(=O)OC(C)(C)C.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)Oc1c(C(F)(F)F)ccc(CBr)c1C(=O)OC(C)(C)C,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20110230482A1,COc1ccc(CNc2nc(Cl)c(Cc3cn(S(=O)(=O)c4ccccc4)c4ncc(Cl)cc34)s2)cn1>>COc1ccc(CNc2nc(Cl)c(Cc3c[nH]c4ncc(Cl)cc34)s2)cn1,,CC(=O)O,,CO,[K+].[OH-],val
US20160068559A1,CC(C)NC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21.COC(=O)CCCC(=O)[O-]>>COC(=O)CCCC(=O)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21)C(C)C,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20080194561A1,CC(C)=O.O=C1CNCCN1c1cccc([N+](=O)[O-])c1>>CC(C)N1CCN(c2cccc([N+](=O)[O-])c2)C(=O)C1,,CO,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US06608084B1,CCOC(=O)/C=C(/C)c1ccc2c(c1)CCN2C(=O)OC(C)(C)C>>CCOC(=O)CC(C)c1ccc2c(c1)CCN2C(=O)OC(C)(C)C,[Pd],CCO,,O=C[O-].[NH4+],,val
US20120232068A1,Cc1cn2cc(Br)cc(S(=O)(=O)NC(C)(C)C)c2n1>>Cc1cn2cc(Br)cc(S(N)(=O)=O)c2n1,,O=C(O)C(F)(F)F,,,,val
US04374829,C[C@H](N)C(=O)N1CCC[C@H]1C(=O)O.O=C(O)C(=O)CCc1ccccc1>>C[C@H](NC(CCc1ccccc1)C(=O)O)C(=O)N1CCC[C@H]1C(=O)O,,O,,[BH3-]C#N.[Na+],,val
US05541324,CC(C)(Nc1c(Cl)cccc1[N+](=O)[O-])C(=O)O.CI>>COC(=O)C(C)(C)Nc1c(Cl)cccc1[N+](=O)[O-],,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090076147A1,CC(C)(COS(=O)(=O)CCCCl)[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O.CC(C)C(=O)[C@H](C)O>>CC(C)C(=O)[C@H](C)OC(=O)[C@H](O[Si](C)(C)C(C)(C)C)C(C)(C)COS(=O)(=O)CCCCl,,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20030207893A1,C=O.CC1CN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CCN1>>CC1CN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CCN1C,CC(=O)O,ClCCl,,[Na],,val
US05648315,COC(=O)c1ccc(CNC(C)=O)cc1S(=O)(=O)NC(C)(C)C>>COC(=O)c1ccc(CNC(C)=O)cc1S(N)(=O)=O,,O=C(O)C(F)(F)F,,,,val
US20040122047A1,COC(=O)CC(c1ccncc1)c1ccc2c(c1)CN(NC(=O)OC(C)(C)C)CC2>>CC(C)(C)OC(=O)NN1CCc2ccc(C(CC(=O)O)c3ccncc3)cc2C1,,CCO,,[Na+].[OH-],,val
US20120283434A1,CC(C)(C)N.CS(=O)(=O)OC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1>>CC(C)(C)NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1,,CC(C)O,,,,val
US20080070928A1,CS(=O)(=O)Cl.Fc1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2C2CCCN2)cc1>>CS(=O)(=O)N1CCCC1c1cc2[nH]c(-c3ccccn3)nc2cc1Oc1ccc(F)cc1,,CCOC(C)=O,,CCN(CC)CC,,val
US05747498,C#Cc1cccc(N)c1.O=[N+]([O-])c1ccc2ncnc(Cl)c2c1>>C#Cc1cccc(Nc2ncnc3ccc([N+](=O)[O-])cc23)c1.Cl,,CC(C)O,,,,val
US20150321983A1,CC(C)(C)C(=O)Cl.O=C(c1ccccc1)c1ccc(OCCO)cc1>>CC(C)(C)C(=O)OCCOc1ccc(C(=O)c2ccccc2)cc1,,ClCCl,,CCN(CC)CC,,val
US05752982,Cc1cccc(N)c1C.O=[N+]([O-])O>>Cc1cc([N+](=O)[O-])cc(N)c1C,,O=S(=O)(O)O,,,,val
US20140294898A1,O=C1OCN(C(=O)OCC2c3ccccc3-c3ccccc32)[C@H]1Cc1cccc2ccccc12>>CN(C(=O)OCC1c2ccccc2-c2ccccc21)[C@@H](Cc1cccc2ccccc12)C(=O)O,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20100249399A1,CCOc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CN(CC2CCNCC2)CCO1.CNOC.O=C(Cl)OC(Cl)(Cl)Cl>>CCOc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CN(CC2CCN(C(=O)N(C)OC)CC2)CCO1,,ClCCl,,Cl,,val
US20070247585A1,CCOc1ccc(C2=CCC(C3CCC4(CC3)OCCO4)CC2)c(F)c1F.OO>>CCOc1ccc(C2CCC(C3CCC4(CC3)OCCO4)CC2O)c(F)c1F,,C1CCOC1,O,CCO,[Na+].[OH-],val
US20130048949A1,CCOP(=O)(OCC)c1ccc(CBr)cc1.OCCN(CCO)c1ccc(N=Nc2ccncc2)cc1>>CCOP(=O)(OCC)c1ccc(C[n+]2ccc(N=Nc3ccc(N(CCO)CCO)cc3)cc2)cc1.[Br-],,ClCCl,,,,val
US20070244153A1,CC(C)[C@@H](CNC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)NC(=O)OC(C)(C)C>>CC(C)[C@H](N)CNC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C,,CCOC(C)=O,,Cl,,val
US06884821B1,CCC(Cc1ccc(O)c(CNC(=O)OC(C)(C)C)c1)(OC(C)C)C(=O)O.CCI>>CCOC(=O)C(Cc1ccc(OCC)c(CNC(=O)OC(C)(C)C)c1)OC(C)C,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20050026963A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=c1ccn(-c2ccccn2)[nH]1>>O=S(=O)(Oc1ccn(-c2ccccn2)n1)C(F)(F)F,,C1CCOC1,,CCN(CC)CC,,val
US20010041707A1,CCOC(=O)CCN.COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)Oc2ccc([N+](=O)[O-])cc2)C(=O)N1>>CCOC(=O)CCNC(=O)N1C(=O)NC(COC)=C(C(=O)OC)[C@@H]1c1ccc(F)c(F)c1,,ClCCl,,CCN(CC)CC,Cl,val
US20100210617A1,CC(C)(C)OC(=O)N1CCC(CBr)(c2ccc(Br)cc2)CC1.COc1cccc(O)c1>>COc1cccc(OCC2(c3ccc(Br)cc3)CCN(C(=O)OC(C)(C)C)CC2)c1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120115811A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccc(-c3ccc(F)cc3)cc21.Cl>>Cl.N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccc(-c3ccc(F)cc3)cc21,,CCOCC,ClCCl,O=C(O)C(F)(F)F,,val
US07432280B2,CC(C)(C)OC(=O)N1CCC[C@@H](O)C1.CCN(CC)CC>>CC(C)(C)OC(=O)N1CCC[C@H](N)C1,,ClCCl,,CS(=O)(=O)Cl,,val
US20110118236A1,C=O.CCN(CC)C(=O)c1ccc(Cn2nc(C(F)(F)F)c3c2CCNC3)cc1>>CCN(CC)C(=O)c1ccc(Cn2nc(C(F)(F)F)c3c2CCN(C)C3)cc1,,O=CO,,,,val
US20030186969A1,CC(C)(C)OC(=O)CBr.O=C1CN(C(=O)c2ccc(Cl)cc2)Cc2ccccc2N1>>CC(C)(C)OC(=O)CN1C(=O)CN(C(=O)c2ccc(Cl)cc2)Cc2ccccc21,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20070167425A1,CC#N.O=Cc1ccc(OCCCc2ccccc2)cc1>>N#CCC(O)c1ccc(OCCCc2ccccc2)cc1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US04248618,CCOC(CCl)OCC.COc1ccc(O)cc1>>CCOC(COc1ccc(OC)cc1)OCC,,O,,[K+].[OH-],,val
US20110306607A1,BrCCBr.COC(=O)c1ccc(O)c(OC)c1>>COC(=O)c1ccc(OCCBr)c(OC)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080119510A1,CCc1cccc(C)c1CNc1cc(Cl)nc(NC)c1[N+](=O)[O-].COCCO>>CCc1cccc(C)c1CNc1cc(OCCOC)nc(NC)c1[N+](=O)[O-],,O,,[H-].[Na+],,val
US06057352,CI.Nc1ccc(Br)cc1.S=C=S>>CSC(=S)Nc1ccc(Br)cc1,,CCOCC,,CCN(CC)CC,,val
US20070281955A1,N#Cc1cccc(-c2nc3sccn3c2-c2ccnc(N[C@@H]3CCCN(S(=O)(=O)c4ccc(Cl)cc4)C3)n2)c1.NO>>NC(=NO)c1cccc(-c2nc3sccn3c2-c2ccnc(N[C@@H]3CCCN(S(=O)(=O)c4ccc(Cl)cc4)C3)n2)c1,,CCO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20040122063A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.O[C@@H]1CCN(Cc2ccccc2)C1>>CC(C)(C)[Si](O[C@@H]1CCN(Cc2ccccc2)C1)(c1ccccc1)c1ccccc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20090186879A1,CCC(O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl.OCC(F)(F)F>>CCC(OCC(F)(F)F)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20120225867A1,COC(=O)c1csc(NC(C)C(C)O)n1>>CC(O)C(C)Nc1nc(C(=O)O)cs1,,C1CCOC1,O,[Li+].[OH-],,val
US20080004309A1,CCCC[Sn](CCCC)(CCCC)CCCC.CCOC(=O)c1nc(Br)c2nc(-c3ccccc3)sc2c1O>>CCCCc1nc(C(=O)OCC)c(O)c2sc(-c3ccccc3)nc12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US20080146623A1,CC(C)(C)OC(=O)NC1(C(=O)O)CC1.O=C(Cc1ccc(CCCCc2ccccc2)cc1)NO>>CC(C)(C)OC(=O)NC1(C(=O)NC(=O)Cc2ccc(CCCCc3ccccc3)cc2)CC1,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20100137290A1,BrC/C=C/CBr.O=C(Nc1ccc2c(c1)OCCO2)OCc1ccccc1>>O=C(OCc1ccccc1)N(CC=CCBr)c1ccc2c(c1)OCCO2,,C1CCOC1,,[Li]CCCC,,val
US20060235033A1,COc1cc2nccc(Oc3ccc(N)cc3F)c2cc1OC.Cc1csc(C(C)N)n1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)NC(C)c4nc(C)cs4)cc3F)c2cc1OC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20060183791A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(Nc1ccc(NCc2ccc(Cl)s2)cc1Cl)C(F)(F)F>>CC(C)(C)OC(=O)N(Cc1ccc(Cl)s1)c1ccc(NC(=O)C(F)(F)F)c(Cl)c1,,CC#N,,,,val
US20100285149A1,COc1ccccc1CCC(=O)Nc1sc2c(c1C#N)CCN(C(=O)OC(C)(C)C)C2>>COc1ccccc1CCC(=O)Nc1sc2c(c1C#N)CCNC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US05827638,CO.O=C(O)C=Cc1cccc([N+](=O)[O-])c1>>COC(=O)C=Cc1cccc(N)c1,,O,,O=S(=O)(O)O,,val
US05344843,CCCc1c(OCCCOc2ccc(C(=O)C(=O)OCC)cc2)ccc(C(=O)OC)c1O>>CCCc1c(OCCCOc2ccc(C(=O)C(=O)O)cc2)ccc(C(=O)OC)c1O,,CO,,[Na+].[OH-],,val
US20140024650A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.OC[C@H]1OCC=C[C@H]1O>>CC(C)(C)[Si](OC[C@H]1OCCC[C@H]1O)(c1ccccc1)c1ccccc1,,CN(C)C=O,,O,,val
US08012901B1,O=C(CBr)c1ccccc1.Oc1cccnc1>>O=C(COc1cccnc1)c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20160272630A1,CCNC(=O)c1cc2c(-c3ccc(C(=O)OC)cc3Oc3c(C)cccc3C)cn(C)c(=O)c2[nH]1>>CCNC(=O)c1cc2c(-c3ccc(C(=O)O)cc3Oc3c(C)cccc3C)cn(C)c(=O)c2[nH]1,,C1CCOC1,O,[Li+].[OH-],,val
US20130109678A1,CO.COCCN(C)c1ccc2[nH]c(-c3ccc(N)c([N+](=O)[O-])c3)nc2c1>>COCCOCCNc1ccc2[nH]c(-c3ccc(N)c(N)c3)nc2c1,[Pd],,,CCOC(C)=O,,val
US20160251339A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=Cc1c[nH]c2cc(F)ccc12>>CC(C)(C)OC(=O)n1cc(C=O)c2ccc(F)cc21,CN(C)c1ccncc1,ClCCl,,,,val
US04171367,CI.Cc1cc(NC(N)=S)n(CCC(C)C)n1>>CSC(=N)Nc1cc(C)nn1CCC(C)C.I,,CCO,,,,val
US20120165345A1,CCOC(=O)C(=O)CC(=O)c1sc(-c2cncc(F)c2)nc1C.CNN>>CCOC(=O)c1cc(-c2sc(-c3cncc(F)c3)nc2C)nn1C,,CCO,,,,val
US20090099156A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)[C@H]1C(=O)O.O=C(Nc1ccc(Cl)c(Cl)c1)N1CCNCC1>>CC(C)(C)OC(=O)N1CCC(C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100172867A1,CN(C(=O)OC(C)(C)C)C1Cc2ccccc2N(Cc2ccc(Cl)c(Cl)c2)C1.O=C(O)C(F)(F)F>>CNC1Cc2ccccc2N(Cc2ccc(Cl)c(Cl)c2)C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20060160803A1,O=C(/C=C/c1ccc(Cc2ccncc2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1>>O=C(CCc1ccc(Cc2ccncc2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1,[Pd],CCOC(C)=O,CO,,,val
US20120122848A1,O=C(OCc1ccccc1)N1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc13.O=C1OI(=O)(O)c2ccccc21>>O=C(OCc1ccccc1)N1CC[C@]23CCCC[C@H]2[C@H]1Cc1cc(O)c(O)cc13,,CO,ClC(Cl)Cl,CC(=O)O,[BH4-].[Na+],val
US03971799,N#Cc1nc(Cl)c(Cl)c(Cl)c1Cl.NN>>N#Cc1nc(Cl)c(Cl)c(NN)c1Cl,,CCO,,CCN(CC)CC,,val
US20040157844A1,CCOC(=O)NC(=O)C(C#N)=NNc1cc(C)c(Oc2ccc(OC)c(Br)c2)c(C)c1>>COc1ccc(Oc2c(C)cc(-n3nc(C#N)c(=O)[nH]c3=O)cc2C)cc1Br,,CC(=O)O,,CC(=O)[O-].[K+],,val
US20100216814A1,CC(=CBr)c1cccs1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>C/C(=C\n1c2c(c3cc(C)ccc31)CN(C)CC2)c1cccs1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20080182854A1,C#Cc1cccc(CO)n1.C1COCCN1>>OCc1cccc(CCN2CCOCC2)n1,,CCO,,,,val
US20110312936A1,CCC(NS(C)(=O)=O)C1CCC2(CC1)OCCO2>>CCC(NS(C)(=O)=O)C1CCC(=O)CC1,,CC#N,,Cl,,val
US20090069327A1,Cc1ccc(N)cc1Nc1ncncc1-c1cc(NCCN2CCOCC2)ncn1.Cn1nc(C(C)(C)C)cc1C(=O)O>>Cc1ccc(NC(=O)c2cc(C(C)(C)C)nn2C)cc1Nc1ncncc1-c1cc(NCCN2CCOCC2)ncn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070004747A1,Cc1cc(-c2n[nH]c3c2CN(C(=O)OC(C)(C)C)CC3)ccc1Cl.ClCC1CO1>>Cc1cc(-c2nn(C3CO3)c3c2C(C)N(C(=O)OC(C)(C)C)CC3)ccc1Cl,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030186985A1,Cc1oc(-c2ccccc2)nc1COc1ccc(CON)cc1.NC(=O)CCCCC(=O)c1ccccc1>>Cc1oc(-c2ccccc2)nc1COc1ccc(CO/N=C(\CCCCC(N)=O)c2ccccc2)cc1,,CCO,O,CC(=O)O,CC(=O)[O-].[Na+],val
US20020176838A1,CCOC(=O)C(C)=C(C)C(C)C>>CCOC(=O)C(C)C(C)C(C)C,[Pt],CCOC(C)=O,,[H][H],,val
US06288061B1,CCOC(=O)C(=NO)C(=O)c1ccc(C)cc1.NCc1ccncc1>>CCOC(=O)c1nc(-c2ccncc2)[nH]c1-c1ccc(C)cc1,,Cc1ccccc1C,,,,val
US20070254892A1,C1CN(CC2CC2)CCN1.CCN(C(C)C)C(C)C.Cc1cc([N+](=O)[O-])ccc1F>>CCc1cc([N+](=O)[O-])ccc1N1CCN(CC2CC2)CC1,,CS(C)=O,,,,val
US20060135578A1,O=C1CSC(=O)N1.O=Cc1cn(-c2ccccc2)nc1OCc1ccccc1>>O=C1NC(=O)/C(=C/c2cn(-c3ccccc3)nc2OCc2ccccc2)S1,,CCO,,C1CCNCC1,,val
US20060004012A1,CC(=O)C=Cc1ccc(OCc2ccccc2C)cc1C>>Cc1cc(OCc2ccccc2C)ccc1C=CC(C)O,,C1CCOC1,,CO,[BH4-].[Na+],val
US04368335,COC(OC)N(C)C.COc1cc(C=O)cc(OC)c1.Nc1cc(Cl)c(N)c(Cl)c1>>COc1cc(CNc2cc(Cl)c(N=CN(C)C)c(Cl)c2)cc(OC)c1,,CCO,,,,val
US20150038438A1,CI.O=C1CCCNc2cc(Cl)ccc21>>CN1CCCC(=O)c2ccc(Cl)cc21,,CN(C)C=O,,O,[H-].[Na+],val
US20100249119A1,CC(C)(C#N)c1cccc(C(=O)Cl)c1.Nc1ccc(Cl)c(O)c1>>CC(C)(C#N)c1cccc(C(=O)Nc2ccc(Cl)c(O)c2)c1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20040077638A1,COc1cccc(N(C)C(=O)c2ccccc2C(=O)O)c1.O=S(Cl)Cl>>COc1cccc(N(C)C(=O)c2ccccc2C(=O)Cl)c1,,C1CCOC1,,Cc1ccccc1,,val
US04259345,C=O.CNC.c1ccn(C2CCCCC2)c1>>CN(C)Cc1cccn1C1CCCCC1,,CCO,O,Cl,,val
US20020137935A1,Cl.Oc1nc(-c2ccccc2)cc2ccncc12>>Clc1nc(-c2ccccc2)cc2ccncc12,,CC(=O)O,,O=C([O-])O.[Na+],,val
US20140288094A1,Br[Mg]C1CC1.Fc1cncc(Br)c1.O=C(Cl)Oc1ccccc1>>O=C(Oc1ccccc1)N1C=C(F)C(C2CC2)C(Br)=C1,I[Cu]I,C1CCOC1,,CSC,,val
US20100197634A1,CC(=O)c1cc(Cl)c(Nc2nc3ccncc3c3c(=O)[nH]ccc23)c(Cl)c1.C[Mg]Br>>CC(C)(O)c1cc(Cl)c(Nc2nc3ccncc3c3c(=O)[nH]ccc23)c(Cl)c1,,C1CCOC1,,,,val
US20010027196A1,CC(O)c1ccccn1.CS(=O)c1nc(N)nc(-c2ccccc2F)c1C#N>>N#Cc1c(OCCc2ccccn2)nc(N)nc1-c1ccccc1F,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20120252801A1,CCN1CC(C)(C)OC(=O)C1CC(=O)O.NCC1CCCCC1>>CCN1CC(C)(C)OC(=O)C1CC(=O)NCC1CCCCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120190677A1,COC(=O)c1ccc2c(c1)C(C)(C)CC(c1cc(Br)ccc1Cl)N2.O=C1NCCO1>>CC1(C)CC(c2cc(N3CCOC3=O)ccc2Cl)Nc2ccc(C(=O)O)cc21,[Cu]I,CC#N,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US04532367,Cc1cccc(Cl)c1O.ClCc1ccc(Cl)c(Cl)c1>>Cc1cc(Cc2ccc(Cl)c(Cl)c2)cc(Cl)c1O,,O,,,,val
US04085272,C#CC(O)COc1ccc(F)cc1.C[Si](C)(C)Cl>>C#CC(COc1ccc(F)cc1)O[Si](C)(C)C,,CCCCCC,,c1c[nH]cn1,,val
US20090111830A1,COC(=O)c1c(Cl)cc(Br)cc1CBr.NCC1CCC(F)(F)CC1>>O=C1c2c(Cl)cc(Br)cc2CN1CC1CCC(F)(F)CC1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20140315881A1,Cc1noc(C)c1-c1nc2ccc(CC(=O)O)cc2[nH]1.O=S(Cl)Cl>>Cc1noc(C)c1-c1nc2ccc(CC(=O)Cl)cc2[nH]1,,ClCCl,,,,val
US20060040949A1,C1=C(CNCc2ccc3c(c2)OCCO3)CNCC1.COc1ccc2nccc(C3CO3)c2c1>>COc1ccc2nccc(C(O)CN3CCC=C(CNCc4ccc5c(c4)OCCO5)C3)c2c1,,CCO,,,,val
US03956384,CC(C)(C)NC(=O)[O-].CNC.Oc1cccc(N=C=S)c1>>CC(C)(C)NC(=O)[O-].CN(C)C(=S)Nc1cccc(O)c1,,CO,,,,val
US20060194841A1,CN[C@](CCN1CCC2(CC1)NC(=O)Cc1ccccc12)(CN(C)C(=O)CC(F)(F)F)c1ccc(Cl)c(Cl)c1.O=C(Cl)c1ccccc1>>CN(C[C@](CCN1CCC2(CC1)NC(=O)Cc1ccccc12)(c1ccc(Cl)c(Cl)c1)N(C)C(=O)c1ccccc1)C(=O)CC(F)(F)F,,CC#N,,CCN(CC)CC,O,val
US20160222028A1,COC[C@H](CO)NCc1ccc(C(=O)OC)cc1Br>>COC[C@@H]1COc2cc(C(=O)OC)ccc2CN1,[Cu]I,CC(C)O,,O=C([O-])[O-].[K+].[K+],,val
US20030060453A1,Nc1cc(C(=O)O)cc([N+](=O)[O-])c1>>Nc1cc(CO)cc([N+](=O)[O-])c1,,C1CCOC1,,,,val
US04788010,O=C(Cl)C(=O)Cl.O=C(O)CC(C1CCCCC1)C1CCCCC1>>O=C(Cl)CC(C1CCCCC1)C1CCCCC1,CN(C)C=O,ClCCl,,,,val
US20050026929A1,COC(=O)c1ccc(CNC(=O)Cc2ccccc2)c(OC)c1>>COc1cc(C(=O)O)ccc1CNC(=O)Cc1ccccc1,,C1CCOC1,,Cl,[Li+].[OH-],val
US05597820,CC[C@H](Cl)C(=O)Cl.COC(=O)c1ccc(N)c(O)c1>>CC[C@H]1Oc2cc(C(=O)OC)ccc2NC1=O,,O,,CCOC(C)=O,O=C([O-])O.[Na+],val
US04277621,CC(C)C1CC=CCCC=CCC(C)(C)C=N1.NNc1ccccc1>>CC(C)C(N)CC=CCCC=CCC(C)(C)C=NNc1ccccc1,,O,,Cl,,val
US20160096827A1,COC(=O)c1c(Nc2ncnc(-c3ccc(O[C@H]4CCN(C(=O)OC(C)(C)C)C[C@H]4F)c(C#N)c3)n2)cnn1C>>COC(=O)c1c(Nc2ncnc(-c3ccc(O[C@H]4CCNC[C@H]4F)c(C#N)c3)n2)cnn1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070078135A1,CC(C)(C)OC(=O)N1CCN(c2ccc(Br)c(-c3ccncc3Cl)n2)CC1.OB(O)c1ccc(C(F)(F)F)cc1>>CC(C)(C)OC(=O)N1CCN(c2ccc(-c3ccc(C(F)(F)F)cc3)c(-c3ccncc3Cl)n2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20110039889A1,CC(C)(C)OC(=O)CCc1nccc2c(C(=N)NO)cccc12.CC(C)Oc1ccc(C(=O)Cl)cc1C#N>>CC(C)Oc1ccc(-c2nc(-c3cccc4c(CCC(=O)OC(C)(C)C)nccc34)no2)cc1C#N,,CN(C)C=O,,CCN(CC)CC,,val
US04704387,COCCCl.O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCNCC1>>COC(C)N1CCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1,,CC(=O)N(C)C,,Br,O=C([O-])[O-].[K+].[K+],val
US20120101083A1,CC(=O)Cl.CC(C)Oc1ccc(-c2nc(-c3ccc4c(c3)CCN(CCN)CC4)no2)cc1C#N>>CC(=O)NCCN1CCc2ccc(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)cc2CC1,,ClCCl,c1ccncc1,Cl,,val
US20060160815A1,CCOC(=O)Oc1ccc(S(=O)(=O)N2c3cc(F)c(F)cc3-n3cccc3C2CC)cc1>>CCC1c2cccn2-c2cc(F)c(F)cc2N1S(=O)(=O)c1ccc(O)cc1,,CO,,[Na+].[OH-],,val
US04262004,BrBr.OCCNC(=S)Nc1ccc(F)cc1>>Br.OCCNc1nc2ccc(F)cc2s1,,ClC(Cl)(Cl)Cl,,,,val
US20160068512A1,COC(=O)c1cccc(CBr)c1.Clc1ccc(C(c2ccc(Cl)cc2)c2ccc3ncnc(NC4CCNCC4)c3c2)cc1>>COC(=O)c1cccc(CN2CCC(Nc3ncnc4ccc(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)cc34)CC2)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100022476A1,O=C(Cc1cc(NC(=O)C(F)(F)F)n[nH]1)Nc1cccc(F)c1F>>Nc1cc(CC(=O)Nc2cccc(F)c2F)[nH]n1,,CO,Cl,O=C([O-])O.[Na+],,val
US20120289549A1,O=C1N(c2ccc(OC(F)(F)F)cc2)C[C@@H]2C[C@@H](Br)CN12.[N-]=[N+]=[N-]>>[N-]=[N+]=N[C@H]1C[C@H]2CN(c3ccc(OC(F)(F)F)cc3)C(=O)N2C1,,CN(C)C=O,,O,,val
US05602277,CCOC(=O)c1ccc(NS(C)(=O)=O)c([N+](=O)[O-])c1>>CCOC(=O)c1ccc(NS(C)(=O)=O)c(N)c1,O=[Pt],CCO,,,,val
US20080176862A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCc1ccc(C=O)cc1O>>CCc1ccc(C=O)cc1O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,[Cl-].[NH4+],val
US20150018341A1,CCC(=C(c1ccc(O)cc1)c1ccc(OCCCl)cc1)c1ccc(O)cn1.CN>>CCC(=C(c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccc(O)cn1,,CO,,,,val
US20140179567A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCCCCCCCCCCCN>>CC(C)(C)OC(=O)NCCCCCCCCCCCCN,,ClC(Cl)Cl,,,,val
US20140243302A1,BrCCBr.O=c1[nH]c(/C=C/c2ccccc2)ncc1O>>C(=C/c1ncc2c(n1)OCCO2)\c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US04687775,CC(=O)OCc1cccn2c(C)cnc12.Sc1nc2ccccc2[nH]1>>Cc1cnc2c(CSc3nc4ccccc4[nH]3)cccn12,,Br,CC(=O)O,,,val
US20120264749A1,COC(=O)c1ccc(OCCO)c(C)c1>>Cc1cc(C(=O)O)ccc1OCCO,,C1COCCO1,,[Na+].[OH-],,val
US04880812,CC(=O)Nc1nc(N(C(C)=O)C(C)=O)c(CC=O)c(=O)[nH]1.COC(=O)CC[C@H](NC(=O)c1ccc(N)cc1)C(=O)OC>>COC(=O)CC[C@H](NC(=O)c1ccc(NCCc2c(N(C(C)=O)C(C)=O)nc(NC(C)=O)[nH]c2=O)cc1)C(=O)OC,,CC(=O)O,,[BH3-]C#N.[Na+],,val
US20100059739A1,CC(C)(C)Cl.c1cc2ccc3cccc4ccc(c1)c2c34>>CC(C)(C)c1ccc2ccc3cccc4ccc1c2c34,,ClCCl,O,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080153852A1,Cc1cc(C)[nH]n1.OC(c1ccccc1I)C(F)(F)F>>Cc1cc(C)n(-c2ccccc2C(O)C(F)(F)F)n1,[Cu]I,CCOC(C)=O,Cc1ccccc1,CN[C@@H]1CCCC[C@H]1NC,O=C([O-])[O-].[K+].[K+],val
US20110092504A1,CS(=O)(=O)Nc1cc(-c2ccc3nccc(C4=CCOCC4)c3c2)cnc1Cl>>CS(=O)(=O)Nc1cc(-c2ccc3nccc(C4CCOCC4)c3c2)cnc1Cl,O=[Pt]=O,,,,,val
US20100105681A1,COC(=O)C(Cc1ccc2nc(Oc3ccccc3)ccc2c1)NC(=O)OC(C)(C)C>>COC(=O)C(N)Cc1ccc2nc(Oc3ccccc3)ccc2c1,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20090018177A1,CCOC(=O)C=Cc1cccc(C(=O)C(C(=O)c2cc(F)cc(F)c2)=C2Nc3ccccc3N2)c1>>O=C(C(C(=O)c1cccc(C=CCO)c1)=C1Nc2ccccc2N1)c1cc(F)cc(F)c1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20050208582A1,CC(=O)OC(C)=O.Cc1nc(Cl)ncc1N>>CC(=O)Nc1cnc(Cl)nc1C,CN(C)c1ccncc1,ClCCl,,O,c1ccncc1,val
US20050090533A1,CC(C)(C)[SiH2]OC(C)(C)[C@@H]1COCCN1Cc1ccccc1>>CC(C)(C)[SiH2]OC(C)(C)[C@@H]1COCCN1,,CCO,,,,val
US20090209607A1,COC(=O)c1cc(Br)c(C)o1.Cn1nccc1B1OC(C)(C)C(C)(C)O1>>Cc1oc(C(=O)O)cc1-c1ccnn1C,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,C1COCCO1,O,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US05624961,CNCCOc1cc(C)c(C(C)=O)cc1C(C)C.COc1c(C)c(C)c(O)c(C)c1CCl>>COc1c(C)c(C)c(O)c(C)c1CN(C)CCOc1cc(C)c(C(C)=O)cc1C(C)C,,CN(C)C=O,,CCN(CC)CC,,val
US04426522,O=C(Cl)c1ccc(Cl)cc1.O=C1CNN(Cc2ccc(Cl)cc2)C(=O)N1>>O=C1CN(C(=O)c2ccc(Cl)cc2)N(Cc2ccc(Cl)cc2)C(=O)N1,,c1ccccc1,,,,val
US20110257174A1,C1COCCN1.O=Cc1cccc(Br)n1>>Brc1cccc(CN2CCOCC2)n1,,ClCCCl,,O=C([O-])O.[Na+],,val
US04699995,BrCCBr.CCCCCCCCC/C=C\c1ccc(O)cc1>>CCCCCCCCC/C=C\c1ccc(OCCBr)cc1,,CC(=O)CC(C)C,,O=C([O-])[O-].[K+].[K+],,val
US06172085B2,OC(c1ccccc1)c1ccccc1.OCCCBr>>BrCCCOC(c1ccccc1)c1ccccc1,,Cc1ccccc1,,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US04874861,Cc1c(S)cnn(C(C)(C)C)c1=O.O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1>>Cc1c(Sc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])cnn(C(C)(C)C)c1=O,,CCO,,[Na+].[OH-],,val
US04698093,CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)Cl)c(C(=O)OC)c1Cl.N>>CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)Cl)c(C(=O)OC)c1N,,CN(C)C=O,,,,val
US20090163508A1,Fc1ccccc1-c1cc(N2CCNCC2)ncn1.O=C(Nc1cccnn1)OCC(Cl)(Cl)Cl>>O=C(Nc1cccnn1)N1CCN(c2cc(-c3ccccc3F)ncn2)CC1,,C1CCOC1,CCCCCC,,,val
US20120122853A1,CCOC(=O)/C=C/c1nc(Br)ccc1N.OB(O)c1ccc(C(F)(F)F)cc1>>CCOC(=O)/C=C/c1nc(-c2ccc(C(F)(F)F)cc2)ccc1N,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120028971A1,O=C(NCC/C=C/C1(C(=O)[O-])CC1)C(c1ccc(CN2N=C(c3ccccc3)OCC2=O)cc1)C1CCCC1>>O=C(NCCC=CC1(C(=O)O)CC1)C(c1ccc(CN2N=C(c3ccccc3)OCC2=O)cc1)C1CCCC1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20150175557A1,CCOC(C)=O.CI.O=C1CCC2(CC1)OCCO2>>CC1(C)CC2(CCC1=O)OCCO2,,C1CCOC1,,[H-].[Na+],,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(O)cc(C)c21.O=[N+]([O-])c1cc(Cl)ccn1>>CCOC(=O)CC1OB(O)c2cc(Oc3ccnc([N+](=O)[O-])c3)cc(C)c21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090324581A1,Cc1c(OCc2cc(C(F)(F)F)n(-c3ccccc3)n2)ccc2c1CCN2C(=O)OC(C)(C)C>>Cc1c(OCc2cc(C(F)(F)F)n(-c3ccccc3)n2)ccc2c1CCN2,,C1COCCO1,Cl,,,val
US20050208582A1,O=P(Cl)(Cl)Cl.[O-][n+]1cccc2c1c(-c1cccc(F)c1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1>>Fc1cccc(-c2n[nH]c3ccc(Cl)nc23)c1,,Cc1ccccc1,,,,val
US04588723,CCN(CC)Cc1nnc(N)s1.O=C(CBr)c1ccccc1>>CCN(CC)Cc1nn2cc(-c3ccccc3)nc2s1,,CN(C)C=O,,O,[Na+].[OH-],val
US20070179196A1,CNC.COC(=O)c1[nH]c(=O)c(O)c2c1CCN(Cc1ccc(F)cc1)C2=O>>CN(C)C(=O)c1[nH]c(=O)c(O)c2c1CCN(Cc1ccc(F)cc1)C2=O,,C1CCOC1,ClCCl,C[Al](C)C,Cl,val
US20140045828A1,Fc1cccc(N2CCOCC2)n1.O=C1CC(Cl)C(=O)N1>>Fc1nc(N2CCOCC2)ccc1Cl,,CC#N,,ClCCl,O,val
US20060030543A1,CC(=O)c1ccc(S(=O)(=O)Cl)cc1.NCc1cccc2ccccc12>>CC(=O)c1ccc(S(=O)(=O)NCc2cccc3ccccc23)cc1,,C1CCOC1,,c1ccncc1,,val
US20080153812A1,C1CNCCN(C2CC2)C1.COC(=O)c1cnc(Cl)nc1>>COC(=O)c1cnc(N2CCCN(C3CC3)CC2)nc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140296200A1,CCOC(=O)c1cnn(-c2ccc(C(=O)NCCCOC)cn2)c1OC>>COCCCNC(=O)c1ccc(-n2ncc(C(=O)O)c2OC)nc1,,C1COCCO1,,Cl,[Li+].[OH-],val
US04486586,CC(C)(C)OC(=O)C1(O/N=C(\C(=O)NC2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(C=CCI)CS[C@H]23)c2csc(NC(c3ccccc3)(c3ccccc3)c3ccccc3)n2)CCC1.Nc1nc2cnccc2s1>>Nc1nc(/C(=N/OC2(C(=O)O)CCC2)C(=O)NC2C(=O)N3C(C(=O)[O-])=C(/C=C/C[n+]4ccc5sc(N)nc5c4)CS[C@H]23)cs1,,CCOC(C)=O,CS(C)=O,,,val
US20090203903A1,Cc1nc(C#Cc2ccc(Cl)nc2)cs1.OB(O)c1ccccc1F>>Cc1nc(C#Cc2ccc(-c3ccccc3F)nc2)cs1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,O=C([O-])[O-].[K+].[K+],,val
US20030018046A1,CC(NCc1cccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c1)c1ccccc1.O=Cc1ccccn1>>CC(c1ccccc1)N(Cc1cccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c1)Cc1ccccn1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120302610A1,CCOC(=O)CCNC(=O)c1ccc(-c2cc(Cl)ccc2C=O)cn1.Nc1ccc(-c2ccc(Cl)cc2)c(Cl)c1>>CCOC(=O)CCNC(=O)c1ccc(-c2cc(Cl)ccc2CNc2ccc(-c3ccc(Cl)cc3)c(Cl)c2)cn1,,CCOC(C)=O,ClCCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140018393A1,C=O.COC(=O)C1(CN(C(=O)C(F)(F)F)[C@H]2C[C@@H]2c2ccccc2)CCNCC1>>COC(=O)C1(CN(C(=O)C(F)(F)F)[C@@H]2C[C@H]2c2ccccc2)CCN(C)CC1,,CO,ClCCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20110098302A1,CC(C(=O)O)c1cccc(Oc2ccc(C(F)(F)F)cc2C=O)c1>>CC(C(=O)O)c1cccc(Oc2ccc(C(F)(F)F)cc2CO)c1,,CO,,[BH4-].[Na+],,val
US04001421,CCC(C)CCCNC(=O)c1cnc(OCC2CO2)s1.NCCOc1ccc(C(N)=O)cc1>>CCC(C)CCCNC(=O)c1cnc(OCC(O)CNCCOc2ccc(C(N)=O)cc2)s1,,CCO,,,,val
US20150280133A1,C[Si](C)(C)Cl.c1ccc(-n2c3ccccc3c3cc(-c4cccc5c4oc4ccccc45)ccc32)cc1>>C[Si](C)(C)c1cccc2c1oc1c(-c3ccc4c(c3)c3ccccc3n4-c3ccccc3)cccc12,,C1CCOC1,,CN(C)CCN(C)C,[Li]CCCC,val
US05962469,Cc1cc2c(c(C)c1O)CC(C)(C)N=C2>>Cc1cc2c(c(C)c1O)CC(C)(C)NC2,[Ni],CCO,,,,val
US20060094768A1,Cc1cc(-c2ccc(C(F)(F)F)cc2)sc1C=O>>OCc1ccc(-c2ccc(C(F)(F)F)cc2)s1,,C1CCOC1,,[BH4-].[Li+],,val
US20150352082A1,COc1cccc(CC(=O)Cl)c1.Nc1nc2ccc(C(F)(F)F)cc2s1>>COc1cccc(CC(=O)Nc2nc3ccc(C(F)(F)F)cc3s2)c1,,C1CCOC1,,,,val
US03994940,CN(C)CCc1nnc(CN2C(=O)c3ccccc3C2=O)n1-c1ccc(F)cc1C(=O)c1ccccc1Cl>>CN(C)CCc1nnc2n1-c1ccc(F)cc1C(c1ccccc1Cl)=NC2,,CCO,,NN,,val
US20050215738A1,CCOC(=O)C(=O)N(c1ccccc1)c1c(C)cc(C)cc1C.Nc1ccccc1O>>Cc1cc(C)c(NC(=O)C(=O)Nc2ccccc2O)c(C)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US05843983,CCCCCCCCOC(=O)N1C[C@H](OC(=O)N(C)C)C[C@H]1CCCl.Oc1cc(Cl)ccc1CCc1ccccc1>>CCCCCCCCOC(=O)N1C[C@H](OC(=O)N(C)C)C[C@H]1CCOc1cc(Cl)ccc1CCc1ccccc1,,CC(=O)N(C)C,,CC(C)(C)[O-].[K+],,val
US04127582,COC(=O)CO.Clc1cc(Cl)c(Cl)nc1Cl>>COC(=O)COc1nc(Cl)c(Cl)cc1Cl,,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US04264518,C=C(C)CCCO.CS(=O)(=O)Cl>>C=C(C)CCCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,O,val
US05821239,CN(C)C(=O)Cl.Oc1cnccc1N=CN1CCCCCC1>>CN(C)C(=O)Oc1cnccc1N=CN1CCCCCC1,,C1CCOC1,,CCN(CC)CC,,val
US06352993B1,C1CCNCC1.Cc1nc(Cl)nc(N2CCc3ccccc3C2)c1C>>Cc1nc(N2CCCCC2)nc(N2CCc3ccccc3C2)c1C.Cl,,CN(C)C=O,,CCN(CC)CC,,val
US20090325928A1,CC1(C)OB(c2ccc3ccc(-c4ccccc4)nc3c2)OC1(C)C.Nc1ncnc2c1c(I)cn2CC1CC1>>Nc1ncnc2c1c(-c1ccc3ccc(-c4ccccc4)nc3c1)cn2CC1CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20070135454A1,COC(=O)c1sccc1N=C=S.Nc1ccc(Cl)nc1>>O=c1c2sccc2[nH]c(=S)n1-c1ccc(Cl)nc1,CN(C)c1ccncc1,CC#N,,,,val
US20130005721A1,CCC(OC(=O)c1ccc([N+](=O)[O-])cc1)(c1cn(Cc2ccn3c(-c4ccc(C)nc4)c(C#N)cc3c2)nn1)C(F)(F)F>>CCC(O)(c1cn(Cc2ccn3c(-c4ccc(C)nc4)c(C#N)cc3c2)nn1)C(F)(F)F,,CO,,[Li+].[OH-],,val
US20100081690A1,CCOC(C)=O.C[Mg]Br.N#Cc1ccc(F)cn1>>CC(=O)c1ccc(F)cn1,,C1CCOC1,,[Cl-].[NH4+],,val
US20030073850A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc([N+](=O)[O-])c2c1C(c1c[nH]cn1)=CCC2>>COc1ccc([N+](=O)[O-])c2c1C(c1cn(C(=O)OC(C)(C)C)cn1)=CCC2,,CC#N,,,,val
US20140031373A1,BrBr.CC(C)C(=O)c1cncnc1>>CC(C)(Br)C(=O)c1cncnc1,,Br,,,,val
US20050148624A1,COC(=O)CCc1ccc(CN)cc1.COC(=O)c1oc(=O)c2ccc(Br)cc2c1-c1ccccc1>>COC(=O)CCc1ccc(Cn2c(C(=O)OC)c(-c3ccccc3)c3cc(Br)ccc3c2=O)cc1,,CO,,,,val
US20120178934A1,CC#CCOc1ccc(C(=O)NCC(C(=O)OC)(C(=O)OC)N2CCN(C(=O)OC(C)(C)C)CC2)cc1.CS(=O)(=O)Cl>>CC#CCOc1ccc(C(=O)NCC(C(=O)OC)(C(=O)OC)N2CCN(S(C)(=O)=O)CC2)cc1,,ClCCl,,CCN(CC)CC,,val
US20080188531A1,CC(=O)Nc1nc(C)c(-c2csc(C(=O)Cl)n2)s1.CNC>>CC(=O)Nc1nc(C)c(-c2csc(C(=O)N(C)C)n2)s1,,C1CCOC1,,CCN(CC)CC,,val
US20060293343A1,CCOC(=O)Cc1ccc(Nc2nc(-c3ccc(C(C)=O)s3)nc(C)c2CC)cc1>>CCOC(=O)Cc1ccc(Nc2nc(-c3ccc(C(C)O)s3)nc(C)c2CC)cc1,,CO,,[BH4-].[Na+],,val
US20050049236A1,CCC(=O)OC(=O)CC.COc1cc(OC)c(-c2cc3ccccc3[nH]2)cc1/C=C/C(=O)c1ccc(S(N)(=O)=O)cc1>>CCC(=O)NS(=O)(=O)c1ccc(C(=O)/C=C/c2cc(-c3cc4ccccc4[nH]3)c(OC)cc2OC)cc1,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,O,val
US04849422,O=C(O)c1cccnc1Cl.OCC(O)CN1CCCNCC1>>O=C(O)c1cccnc1N1CCCN(CC(O)CO)CC1,,C1COCCO1,,,,val
US20160237090A1,C[C@H]1Cn2ncc(N3CC(CO[Si](C)(C)C(C)(C)C)CC3=O)c2CN1C(=O)Nc1ccc(F)c(Cl)c1>>C[C@H]1Cn2ncc(N3CC(CO)CC3=O)c2CN1C(=O)Nc1ccc(F)c(Cl)c1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160151284A1,CC/C=C\CCO.CS(=O)(=O)Cl>>CC/C=C\CCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US04634704,Cn1cnc([N+](=O)[O-])c1Cl.NCCN1CCC(Nc2nc3cccnc3n2Cc2ccc(F)cc2)CC1>>Cn1cnc([N+](=O)[O-])c1NCCN1CCC(Nc2nc3cccnc3n2Cc2ccc(F)cc2)CC1,,CN(C)C=O,,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20130085148A1,CC(=O)c1ccncc1.Fc1ccc(-c2nnco2)cc1>>CC(O)(c1ccncc1)c1nnc(-c2ccc(F)cc2)o1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20100331314A1,C1CCNCC1.CC(C)(C)c1cccc(Nc2ccn3ncc(C=O)c3n2)c1.O=C1CSC(=O)N1>>CC(C)(C)c1cccc(Nc2ccn3ncc(C=C4NC(=O)NC4=O)c3n2)c1,,CCO,,,,val
US20090005421A1,C[Mg]I.Cc1cc(-c2nnc(-c3sc(C)c4c3C[C@@H]3[C@H]4C3(C)C)o2)cc(Cl)n1>>Cc1cc(-c2nnc(-c3sc(C)c4c3C[C@@H]3[C@H]4C3(C)C)o2)cc(C)n1,,C1CCOC1,,CN1CCCC1=O,,val
US20080167307A1,COB(OC)OC.Fc1cc(Cl)ccc1Br>>OB(O)Oc1ccc(Cl)cc1F,,C1CCOC1,CCCCCC,Cl,[Li]CCCC,val
US04698093,CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)F)c(C(=O)OC)c1Cl.CCS>>CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)F)c(C(=O)OC)c1SCC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160075710A1,CC(N)c1cc(=O)n(Cc2ccccc2)nc1-c1ccccc1.N#Cc1c(N)ncnc1Cl>>CC(Nc1ncnc(N)c1C#N)c1cc(=O)n(Cc2ccccc2)nc1-c1ccccc1,,CC(C)(C)O,,CCN(C(C)C)C(C)C,,val
US04567126,C=CCN(CC=C)c1ccccc1C=O.NNc1ccccc1>>C=CCN(CC=C)c1ccccc1C=NNc1ccccc1,,CO,,,,val
US20130018049A1,Fc1cccc(CBr)c1F.O=C1CCCN1>>O=C1CCCN1Cc1cccc(F)c1F,,CN(C)C=O,,O,[H-].[Na+],val
US05122523,CC(C)C[C@H](NC(=O)OC(C)(C)C)C(O)C(O)CSC(C)C.Cl>>CC(C)C[C@H](N)C(O)C(O)CSC(C)C.Cl,,C1COCCO1,,,,val
US20080214519A1,COC(=O)c1cc(OC2CCOc3ccccc32)c2nc(C)n(C)c2c1>>Cc1nc2c(OC3CCOc4ccccc43)cc(C(=O)O)cc2n1C,,C1CCOC1,,CO,[Li+].[OH-],val
US05459260,CC(C)(C)[Si](C)(C)Cl.O=C1CCCCC1CCO>>CC(C)(C)[Si](C)(C)OCCC1CCCCC1=O,,CCCCCC,CN(C)C=O,c1c[nH]cn1,,val
US20100210617A1,CCc1ccn(S(=O)(=O)N(C)C)n1.O=C1CCC(=O)N1Br>>CCc1nn(S(=O)(=O)N(C)C)cc1Br,,C1CCOC1,,O,,val
US20070129544A1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.O=C(O)c1ccc(-c2noc([C@H]3CCCCN3C(=O)COc3ccccc3)n2)cc1>>NC(=O)c1ccc(-c2noc([C@H]3CCCCN3C(=O)COc3ccccc3)n2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20030232869A1,C1COCCN1.CC(C)(C)OC(=O)NOCCBr>>CC(C)(C)OC(=O)NOCCN1CCOCC1,,CCOC(C)=O,CN(C)C=O,,,val
US05180723,CNC1CCCCC1.Cc1ccc(C(=O)Cl)cc1>>Cc1ccc(C(=O)N(C)C2CCCCC2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20150051197A1,O=C(NCCCCl)Nc1ccc(Oc2ccc(Cl)cc2)cc1>>O=C1NCCCN1c1ccc(Oc2ccc(Cl)cc2)cc1,,O,,C1CCOC1,[H-].[Na+],val
US20120245161A1,CCCCn1cc(C(=O)C(F)(F)F)c2c(OC)cccc21.[OH-]>>CCCCn1cc(C(=O)O)c2c(OC)cccc21,,O,,Cl,,val
US20100160362A1,COCOc1cnc(OC)cc1C1(O)C(=O)N(Cc2ccc(C(F)(F)F)o2)c2ccccc21>>COCOc1cnc(OC)cc1C1C(=O)N(Cc2ccc(C(F)(F)F)o2)c2ccccc21,[Zn],ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US04143047,CCCCC(C)(C)C(N)=O.Ic1nc(-c2ccccc2)c(-c2ccccc2)o1>>CCCCN(C(=O)C(C)C)c1nc(-c2ccccc2)c(-c2ccccc2)o1,,C1CCOC1,CCCCCC,O,[Li]CCCC,val
US04970225,COC(=O)CCCCCCCCN1C(=O)C(c2ccccc2)N(c2ccccc2)C1=O>>O=C(O)CCCCCCCCN1C(=O)C(c2ccccc2)N(c2ccccc2)C1=O,,Cl,,,,val
US20080269240A1,CC(C)CN.CCCCOc1nc(N)c2[nH]c(=O)n(CCCBr)c2n1>>CCCCOc1nc(N)c2[nH]c(=O)n(CCCNCC(C)C)c2n1,,CS(C)=O,,,,val
US20070276000A1,COC1=C(C)C(=O)C1(OC)OC.COc1cccc([Mg]Br)c1>>COc1cccc(C2=C(C)C(=O)C2(OC)OC)c1,,C1CCOC1,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US04385177,CONC(=O)CCl.O=C(O)/C(=N\O)c1cccs1>>CONC(=O)CO/N=C(\C(=O)O)c1cccs1,,CS(C)=O,,,,val
US06583253B1,C=C.CC(C)C[Al](CC(C)C)CC(C)C.CCCCCCC>>C=C.C=CC.C=CCC,,CCCCCCC,,,,val
US20090062348A1,Nc1ncccc1C(=O)NCc1cc2ccc(OCc3ccccc3)cc2o1>>Nc1ncccc1C(=O)NCc1cc2ccc(O)cc2o1,,O=C(O)C(F)(F)F,,O,O=C([O-])O.[Na+],val
US20130237555A1,CC(C)C[C@@H](COc1cc2c(cc1Cl)-c1ccncc1C(C(F)(F)F)O2)NC(=O)OC(C)(C)C>>CC(C)C[C@H](N)COc1cc2c(cc1Cl)-c1ccncc1C(C(F)(F)F)O2,,ClCCl,,CCOCC,Cl,val
US05840911,Cl.Cl.N=C(NO)c1cccc2c1CCC2=Nn1cc(-c2ccc(F)cc2)nc1N>>Cl.Cl.N=C(N)c1cccc2c1CCC2=Nn1cc(-c2ccc(F)cc2)nc1N,[Ni],CO,O,,,val
US20130060041A1,CCN=C(SC)N1CC(C)(C)C=N1.NS(=O)(=O)c1ccc(NC(=O)C(F)(F)F)c(Br)c1>>CCNC(=NS(=O)(=O)c1ccc(NC(=O)C(F)(F)F)c(Br)c1)N1CC(C)(C)C=N1,,CC#N,,,,val
US20090163472A1,C[C@@H](N)CN1CCOCC1.O=[N+]([O-])c1cc(Br)ccc1F>>C[C@H](CN1CCOCC1)Nc1ccc(Br)cc1[N+](=O)[O-],CN(C)c1ccccn1,CCOC(C)=O,,CCN(CC)CC,Cl,val
US20150232481A1,C=CCBr.C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OCC)c(C)nc3cc(Cn4cc(-c5ccccc5CO)nn4)nn23)CC1>>C=CCOCc1ccccc1-c1cn(Cc2cc3nc(C)c([C@H](OC(C)(C)C)C(=O)OCC)c(N4CCC(C)(OCC=C)CC4)n3n2)nn1,,CN(C)C=O,,[H-].[Na+],,val
US05256675,CC(=O)Nc1nc(CS(=O)(=O)c2ccc(N)cc2)cs1>>Nc1ccc(S(=O)(=O)Cc2csc(N)n2)cc1,,CC(=O)O,,Cl,O=C([O-])O.[Na+],val
US20140275120A1,CC(C)(C)OC(=O)N1CCc2c(ncnc2-c2ccccn2)C1>>c1ccc(-c2ncnc3c2CCNC3)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100184789A1,COc1ccccc1-c1ccnc(Cl)n1.Nc1cccc(CS(N)(=O)=O)c1>>COc1ccccc1-c1ccnc(Nc2cccc(CS(N)(=O)=O)c2)n1,,CN(C)C=O,,,,val
US20060128732A1,Cl.O=C(NC1=Nc2ccccc2C2=NCCN12)c1cccnc1>>Cl.O=C(NC1=Nc2ccccc2C2=NCCN12)c1cccnc1,,C1CCOC1,,C1COCCO1,,val
US20140288081A1,CCOCC1(O)CCN(C(=O)OC(C)(C)C)CC1>>CCOCC1(O)CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05624943,COC(=O)CCCC(=O)c1ccc(OC)c(CCC(=O)OC)n1>>O=C(O)CCCC(=O)c1ccc(O)c(CCC(=O)O)n1,,Br,,,,val
US04269788,CC(CC1(c2ccccc2)C=CCC=C1)OS(C)(=O)=O.CNC>>CC(CC1(c2ccccc2)C=CCC=C1)N(C)C,,Cc1ccccc1,,,,val
US20030220368A1,COc1ncccc1CCl.[C-]#N>>COc1ncccc1CC#N,,O,,CN(C)C=O,,val
US20160200674A1,Nc1cc(-c2ccccc2-c2nnn[nH]2)ccc1N1CCCc2ccccc21.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>O=C(Nc1cc(-c2ccccc2-c2nnn[nH]2)ccc1N1CCCc2ccccc21)Oc1ccc([N+](=O)[O-])cc1,,C1CCOC1,,,,val
US20080269196A1,CC(C)N.N#Cc1ccc(C=O)cc1>>CC(C)NCc1ccc(C#N)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US04673746,CCOC(=O)C(C)(C)Sc1ccc2c(-c3ccccc3F)noc2c1Cl>>CC(C)(Sc1ccc2c(-c3ccccc3F)noc2c1Cl)C(=O)O,,CO,,[Na+].[OH-],,val
US20110275678A1,NC1CCCC1.O=C(OCc1ccncc1)Oc1ccc([N+](=O)[O-])cc1>>O=C(NC1CCCC1)OCc1ccncc1,CN(C)c1ccncc1,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US06001997,COCC1CCC(C(=O)O)O1.O=C(Cl)C(=O)Cl>>COCC1CCC(C(=O)CCl)O1,CN(C)C=O,ClCCl,,,,val
US20040235822A1,CCCn1c(CO)nnc1SC.ClC(Cl)Cl.O=S(Cl)Cl>>CCCn1c(CCl)nnc1SC.Cl,,O=S(Cl)Cl,,,,val
US20100004249A1,CC(C)(C)OC(=O)N1CCNC(CO)C1.O=C=Nc1cccc(F)c1>>CC(C)(C)OC(=O)N1CCN(C(=O)Nc2cccc(F)c2)C(CO)C1,,C1CCOC1,,,,val
US20040072830A1,COCCl.Oc1ccc(I)nc1Cc1ccccc1>>COCOc1ccc(I)nc1Cc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20070037802A1,CN.Cl.O=S(=O)(c1cccc2ccccc12)c1n[nH]c2cc(OCCCl)ccc12>>CNCCOc1ccc2c(S(=O)(=O)c3cccc4ccccc34)n[nH]c2c1.Cl,,CS(C)=O,O,CCOCC,,val
US20130211075A1,CC(=O)Cl.Cc1cc(NC(=O)c2cnn(-c3ccc(C(F)(F)F)cn3)c2C)cnc1C1=CCNCC1>>CC(=O)N1CC=C(c2ncc(NC(=O)c3cnn(-c4ccc(C(F)(F)F)cn4)c3C)cc2C)CC1,,c1ccncc1,,O,,val
US20120232051A1,O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(NCCNc1cnccc1-c1ccccc1Cl)OCc1ccccc1>>O=C(NCCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1-c1ccccc1Cl)OCc1ccccc1,,CCCCCCC,CCOC(C)=O,,,val
US20150210678A1,CC1(c2ccccc2C=O)COC1.NC1CC1>>CC1(c2ccccc2CNC2CC2)COC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20100137338A1,Cn1ncnc1-c1ccc(C(=O)O)cc1.N[C@@H](Cc1ccccc1C(F)(F)F)CN1C(=O)c2ccccc2C1=O>>Cn1ncnc1-c1ccc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)cc1,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20020103248A1,CCC1(CC)C(=O)Nc2ccc(-c3cccc(Cl)c3)cc21.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCC1(CC)C(=S)Nc2ccc(-c3cccc(Cl)c3)cc21,,Cc1ccccc1,,,,val
US20150307507A1,CCc1cccc[n+]1[O-].O=[N+]([O-])O>>CCc1cc([N+](=O)[O-])cc[n+]1[O-],,O=S(=O)(O)O,,[Na+].[OH-],,val
US20100113510A1,C1CCNCC1.COC(=O)C(C)(Br)c1ccccc1>>COC(=O)C(C)(c1ccccc1)N1CCCCC1,,CC#N,,,,val
US20090143428A1,CC(C)(C)[Si](C)(C)OCCN[C@H]1CCN(c2ccc3c(C(=O)NCC4(O)CCCCCC4)c(Cl)ccc3n2)C1>>O=C(NCC1(O)CCCCCC1)c1c(Cl)ccc2nc(N3CC[C@H](NCCO)C3)ccc12,,C1CCOC1,,Cl,,val
US20130225584A1,Cc1nocc1NC(=O)c1cc(Br)c(CN2CCOCC2)cc1OCc1ccc(F)cc1F.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>Cc1nocc1NC(=O)c1cc(-c2cnn(C)c2)c(CN2CCOCC2)cc1OCc1ccc(F)cc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20050054627A1,CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](N)C2=O)[C@H](CS(=O)(=O)C(C)C)C1.Cn1nc(C(C)(C)C)cc1C(=O)O>>CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cc(C(C)(C)C)nn3C)C2=O)[C@H](CS(=O)(=O)C(C)C)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140275065A1,CCCC[Sn](CCCC)(CCCC)c1ncccc1C.COC(=O)c1nc(C)ccc1Br>>COC(=O)c1nc(C)ccc1-c1ncccc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US05723450,COc1c(NC2CCC3(CC2)OCCO3)ccnc1C.Cl>>COc1c(NC2CCC(=O)CC2)ccnc1C.Cl,,O=CO,,,,val
US20100273744A1,Cc1cnccc1C(=O)Nc1ccn(Cc2ccc(C3CC3)cc2C(F)(F)F)n1.Cl>>Cc1cnccc1C(=O)Nc1ccn(Cc2ccc(C3CC3)cc2C(F)(F)F)n1.Cl,,CO,,C1COCCO1,,val
US20110118283A1,CC(C)(C)OC(=O)CC#N.Clc1ncc(Br)cn1>>CC(C)(C)OC(=O)C(C#N)c1ncc(Br)cn1,,C1CCOC1,,O,[H-].[Na+],val
US20030171392A1,O=c1[nH]c2c(c3ccccc13)C(O)c1ccccc1-2>>O=c1[nH]c2c(c3ccccc13)Cc1ccccc1-2,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20080171772A1,CCOC(=O)c1ccc2c(C(=O)O)c(C(C)C)n(Cc3ccccc3)c2c1.OCc1ccc(F)c(F)c1>>CCOC(=O)c1ccc2c(C(=O)OCc3ccc(F)c(F)c3)c(C(C)C)n(Cc3ccccc3)c2c1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,ClCCCl,,val
US04772705,CCOC(=O)C(Br)c1ccccc1.NCCN>>O=C1NCCNC1c1ccccc1,,CCO,,,,val
US20150023913A1,CCOC(=O)C1(C(F)F)CC1>>O=C(O)C1(C(F)F)CC1,,CO,O,[K+].[OH-],,val
US20110077252A1,N#Cc1ccc(N)nc1.O=C(Cl)CCl>>N#Cc1cncc(NC(=O)CCl)c1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US04970332,CCCCC(CC)COC(=O)C=Cc1ccc(OC)cc1>>COC(=O)C=Cc1ccc(OC)cc1,[Pd],,,,,val
US20160115177A1,C=CC#N.COC(=O)CS>>COC(=O)C1=C(N)CCS1,,CO,,C1CCC2=NCCCN2CC1,,val
US20040242584A1,CCOC(=O)c1ccc(-c2c(F)cccc2F)nc1>>O=C(O)c1ccc(-c2c(F)cccc2F)nc1,,CO,,[Na+].[OH-],,val
US20110190269A1,COc1cc(Br)ccc1-n1cnc(C)c1.Cc1cc(-c2ccc(Cl)cc2C=O)c2nc(N)nn2c1>>COc1cc(Nc2nc3c(-c4ccc(Cl)cc4C=O)cc(C)cn3n2)ccc1-n1cnc(C)c1,,CO,ClCCl,,,val
US20060004045A1,[N-]=[N+]=NCC(F)(F)c1cccc[n+]1[O-]>>[O-][NH2+]CC(F)(F)c1ccccn1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160200704A1,COC(=O)c1ccc2c(c1)c(Cl)cn2C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)n1cc(Cl)c2cc(CO)ccc21,,C1CCOC1,,,,val
US20060035938A1,CSc1ccc(CN)cc1.Cc1ccc(C(=O)O)c(=O)n1-c1cccc(C(F)(F)F)c1>>CSc1ccc(CNC(=O)c2ccc(C)n(-c3cccc(C(F)(F)F)c3)c2=O)cc1,,CCOC(C)=O,CN1CCCC1=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160115168A1,CC(C)(C)OC(=O)N1CCC[C@@H](n2nc(C(=O)Nc3nc4cc(C#N)ccc4o3)c3c(N)ncnc32)C1.ClCCl.O=C(O)C(F)(F)F>>C=CC(=O)N1CCC[C@@H](n2nc(C(=O)Nc3nc4cc(C#N)ccc4o3)c3c(N)ncnc32)C1,,ClCCl,,,,val
US20120046285A1,CC(C)(C)OC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.COC(=O)c1ccc(C=O)nc1>>COC(=O)c1ccc(/C=C/C(=O)OC(C)(C)C)nc1,,O,,,,val
US20110319425A1,CC(=O)Cl.O=C1CCCC(=O)C1>>CC(=O)OC1=CC(=O)CCC1,,ClC(Cl)Cl,,c1ccncc1,,val
US07195719B1,CCCCC(=O)[C@H](C)C(=O)OCC>>CCCCC(=O)[C@H](C)C(=O)O,,CO,,[K+].[OH-],,val
US20110110855A1,COC(=O)CCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1>>O=C(O)CCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,O,[Na+].[OH-],,val
US20150018335A1,COC(=O)c1ccc(Br)c(C)n1>>Cc1nc(C=O)ccc1Br,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20110190489A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.OC1(c2ccc(Br)cc2)COC1>>CC1(C)OB(c2ccc(C3(O)COC3)cc2)OC1(C)C,,CN(C)C=O,,CC(=O)[O-].[K+],,val
US20110257170A1,COC(=O)c1cc(SC)c2nc(Cl)nc(N3CCOCC3)c2n1.OB(O)c1cn[nH]c1>>COC(=O)c1cc(SC)c2nc(-c3cn[nH]c3)nc(N3CCOCC3)c2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100197683A1,CCC1CO1.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)[nH]c2ncnn12>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(CC(O)CC)c2ncnn12,,CCOC(C)=O,,CC(=O)N(C)C,O=C([O-])[O-].[K+].[K+],val
US20060281809A1,C=CCC1=C(CC[C@](C)(O)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(=O)C(C)=C(C)C1=O>>CCCC1=C(CC[C@](C)(O)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(=O)C(C)=C(C)C1=O,O=[Pt]=O,ClCCl,,CCOC(C)=O,,val
US20070179173A1,CCCCCOC(=O)Cl.COc1ccc(CC2SC(=O)NC2=O)c2c1N(Cc1ccc(N)cc1)C(=O)CC2>>CCCCCOC(=O)Nc1ccc(CN2C(=O)CCc3c(CC4SC(=O)NC4=O)ccc(OC)c32)cc1,,ClCCl,,Cl,c1ccncc1,val
US20160083391A1,CCOC(=O)Cl.COC(=N)COC(C)=O>>CCOC(=O)N=C(COC(C)=O)OC,,CC(Cl)Cl,,CCN(CC)CC,Cl,val
US20110015230A1,CCCOc1cc(C(F)(F)F)ccc1C(=O)N(C)OC>>CCCOc1cc(C(F)(F)F)ccc1C=O,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150133289A1,CC(=O)CCO.CCOC(=O)Cl>>CCOC(=O)OCCC(C)=O,,ClCCl,,c1ccncc1,,val
US20100292243A1,CC(C)O.Cl.Clc1ccc([C@@H]2CNCc3cc(-c4ccc5ncnn5c4)ccc32)cc1Cl.O>>CC(C)[O-].Cl.Clc1ccc([C@@H]2CNCc3cc(-c4ccc5ncnn5c4)ccc32)cc1Cl.O,,CC(C)O,,,,val
US20100087427A1,CC(C)NC[C@H]1CN(Cc2ccccc2)C[C@H]1Cc1ccccc1.COCCCOc1cc(C(=O)O)ccc1OC>>COCCCOc1cc(C(=O)N(C[C@H]2CN(Cc3ccccc3)C[C@H]2Cc2ccccc2)C(C)C)ccc1OC,,ClCCl,,CCN(CC)CC,O=C1OCCN1P(=O)(Cl)N1CCOC1=O,val
US20100105744A1,CC[S-].O=[N+]([O-])c1ccccc1CBr>>CCSCc1ccccc1[N+](=O)[O-],,O,,CN(C)C=O,,val
US20080096907A1,BrCc1ccc(Br)cc1.Cc1c[nH]c(=O)[nH]c1=O>>Cc1cn(Cc2ccc(Br)cc2)c(=O)[nH]c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070105842A1,N#Cc1cccnc1Cl.Oc1cccnc1>>N#Cc1cccnc1Oc1cccnc1,,CN(C)C=O,,[H-].[Na+],,val
US20110152295A1,CN(C)C=O.O=C(O)c1cnc(Cl)nc1>>NC(=O)c1cnc(Cl)nc1,,C1CCOC1,,O=C(Cl)C(=O)Cl,,val
US20090203737A1,CC(C)(C)OC(=O)N1CCCC(c2noc(-c3ncc[nH]3)n2)C1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.c1c[nH]c(-c2nc(C3CCCNC3)no2)n1,,ClCCl,,,,val
US20150232445A1,BrC1CCC1.C[C@H]1CCc2c(ccc(-n3nccn3)c2O)N1C(=O)C1CC1>>C[C@H]1CCc2c(ccc(-n3nccn3)c2OC2CCC2)N1C(=O)C1CC1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04959361,C#CCN1C(=O)COc2ccc(Cl)cc21.Cc1nnc2n1-c1sc(I)cc1C(c1ccccc1Cl)=NC2>>Cc1nnc2n1-c1sc(C#CCN3C(=O)COc4ccc(Cl)cc43)cc1C(c1ccccc1Cl)=NC2,,ClCCl,,CCO,,val
US04366153,O=C(O)C1=C(C(CCO)Sc2nnn[nH]2)CS[C@@H]2C(NC(=O)C(=NOC3CCCC3)c3csc(NC(=O)C(F)(F)F)n3)C(=O)N12>>Nc1nc(C(=NOC2CCCC2)C(=O)NC2C(=O)N3C(C(=O)O)=C(C(CCO)Sc4nnn[nH]4)CS[C@H]23)cs1,,C1CCOC1,,O,CC(=O)[O-].[Na+],val
US20050277630A1,CC(=O)NC[C@H]1CN(c2ccc3c(c2)OCCC(C(=O)c2ccco2)C3=O)C(=O)O1.NN>>CC(=O)NC[C@H]1CN(c2ccc3c(c2)OCCc2c(-c4ccco4)n[nH]c2-3)C(=O)O1,,CCO,,O,,val
US20160090364A1,O=C=Nc1ccc(Br)cc1.c1ccc2c(c1)CCN2>>O=C(Nc1ccc(Br)cc1)N1CCc2ccccc21,,CCOC(C)=O,ClCCl,,,val
US20120115844A1,COC(=O)c1cnc(OCc2c(-c3ccc(F)cc3)nnn2C)cn1>>Cn1nnc(-c2ccc(F)cc2)c1COc1cnc(C(=O)O)cn1,,C1CCOC1,O,[Li+].[OH-],,val
US20110257100A1,Cn1c(CN2CCOCC2)cnc1-c1cc2nccc(Oc3ccc(N)cc3F)c2s1.NC1CC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cn1c(CN2CCOCC2)cnc1-c1cc2nccc(Oc3ccc(NC(=O)NC4CC4)cc3F)c2s1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20040087659A1,CN=C=O.COc1ccc(N)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl>>CNC(=O)Nc1ccc(OC)c(NC(=O)NC(=O)c2cc(F)c(F)cc2Cl)c1,,CC#N,,,,val
US06048866,Clc1ccnc(Cl)n1.O=C(O)c1cccc(S)c1>>O=C(O)c1cccc(Sc2ccnc(Cl)n2)c1,,CCO,,,,val
US20110152519A1,COc1ccc(C=Cc2nc(N3CCOCC3)c([N+](=O)[O-])c(N3CCOCC3)n2)cc1>>COc1ccc(C=Cc2nc(N3CCOCC3)c(N)c(N3CCOCC3)n2)cc1,[Zn],CC#N,O,[Ca+2].[Cl-].[Cl-],,val
US05331084,C1=CCC=C1.CC(=O)OO.FC(F)=C(F)C(F)(F)F>>FC(F)(F)C1(F)C2CC(C3OC32)C1(F)F,,ClCCl,,,,val
US20100298336A1,CCOC(=O)Cl.Clc1cncc(Br)c1>>CCOC(=O)c1c(Cl)cncc1Br,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20090099181A1,CO.CS(=O)c1cccc(CC(=O)O)c1>>COC(=O)Cc1cccc(S(C)=O)c1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20120003273A1,CC(C)I.Oc1ccc2c(c1)OCC1c3ccccc3OC21>>CC(C)Oc1ccc2c(c1)OCC1c3ccccc3OC21,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20140213586A1,COc1cccc(N)c1.Cc1cccn2cc(C=O)nc12>>COc1cccc(N=Cc2cn3cccc(C)c3n2)c1,,CCO,,,,val
US04147692,C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)NCC(=O)N1CCC[C@H]1C(=O)O>>O=C(NC1CCCCC1)NC1CCCCC1,,C1CCOC1,,,,val
US20080188528A1,CCOC(=O)c1ccc[nH]c1=O.COc1cc2ccccc2cc1CBr>>CCOC(=O)c1cccn(Cc2cc3ccccc3cc2OC)c1=O,,CN(C)C=O,,Cl,[H-].[Na+],val
US20050267149A1,CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.O=C(O)COc1ccc(O)cc1>>CCN(Cc1ccccc1F)C(=O)COc1ccc(O)cc1,,CN(C)C=O,,CCOC(C)=O,,val
US20120028961A1,CC(=O)c1ccc(C)s1>>Cc1ccc(C(C)O)s1,,CO,,[BH4-].[Na+],,val
US20070093496A1,C=CCBr.CN1CCn2c(Br)c(C(=O)NCc3ccc(F)c(Cl)c3)c(OCc3ccccc3)c2C1=O>>C=CCN(Cc1ccc(F)c(Cl)c1)C(=O)c1c(OCc2ccccc2)c2n(c1Br)CCN(C)C2=O,,CN(C)C=O,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20110130453A1,CCOC(=O)Cc1ccc(OC)c(Oc2ccc(N)cc2CN(CC)C(=O)OCc2ccccc2)c1.O=C(Cl)c1ccc(Cl)cc1>>CCOC(=O)Cc1ccc(OC)c(Oc2ccc(NC(=O)c3ccc(Cl)cc3)cc2CN(CC)C(=O)OCc2ccccc2)c1,,ClCCl,,CCN(CC)CC,,val
US20030060633A1,CC(C)(C)OC(=O)CC(=O)CC(O)CCc1ccc(F)cc1>>O=C1CC(=O)OC(CCc2ccc(F)cc2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140031336A1,CC(=O)N1c2ccc(-c3ccc(CC(=O)NCCNC(=O)OC(C)(C)C)cc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.Cl>>CC(=O)N1c2ccc(-c3ccc(CC(=O)NCCN)cc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.Cl,,C1COCCO1,,,,val
US20090069340A1,CCn1c(CBr)c(Cl)c(=O)n1C1CCCCC1.N#CC1(c2ccccc2)CCNCC1>>CCn1c(CN2CCC(C#N)(c3ccccc3)CC2)c(Cl)c(=O)n1C1CCCCC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160068512A1,FC(F)(F)c1cccc(CNc2nc(Cl)nc3ccc(C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)cc23)c1.OCCCCO>>OCCCCOc1nc(NCc2cccc(C(F)(F)F)c2)c2cc(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)ccc2n1,,C1CCOC1,,[H-].[Na+],,val
US05656626,COc1c(C=C(C)C(=O)OC(C)(C)C)c(=O)c2ccc(Cl)cc2[nH]c1=O>>COc1c(/C=C(\C)C(=O)O)c(=O)c2ccc(Cl)cc2[nH]c1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04525356,CCN(CC)CCN.COc1ccc(-c2oc3c(C(=O)O)cccc3c(=O)c2C)cc1>>CCN(CC)CCNC(=O)c1cccc2c(=O)c(C)c(-c3ccc(OC)cc3)oc12,,C1CCOC1,,CCN(CC)CC,CCOC(=O)Cl,val
US20090275578A1,COC(=O)c1c(C)cccc1I.NC(=O)CCC(=O)NBr>>COC(=O)c1c(I)cccc1CBr,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20060094708A1,CC(C)Oc1ccc(C(=O)N[C@H](CN)Cc2ccc(-c3cn4cccc(Br)c4n3)cc2)cc1Cl.C[C@@H](NC(=O)OC(C)(C)C)C(=O)O>>CC(C)Oc1ccc(C(=O)N[C@H](CNC(=O)[C@@H](C)N)Cc2ccc(-c3cn4cccc(Br)c4n3)cc2)cc1Cl,,C1COCCO1,ClCCl,CCN=C=NCCCN(C)C,Cl,val
US20110136764A1,CCOP(=O)(OCC)C(F)(F)Br.O=[N+]([O-])c1ccc(I)cc1>>CCOP(=O)(OCC)C(F)(F)c1ccc([N+](=O)[O-])cc1,Cl[Cu],CN(C)C=O,,CCOCC,,val
US20140057915A1,CC(C)(C#N)C(=O)CC#N.Cc1ccc(NN)cc1>>Cc1ccc(-n2nc(C(C)(C)C#N)cc2N)cc1,,CCO,,Cl,,val
US20150274750A1,CN(C)CC(c1ccc(Cl)cc1)N1CCNCC1.Clc1ncnc2c1OCCN2>>CN(C)CC(c1ccc(Cl)cc1)N1CCN(c2ncnc3c2OCCN3)CC1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20070219229A1,CC=C[Mg]Br.O=[N+]([O-])c1cc(Br)cnc1Cl>>Cc1c[nH]c2c(Cl)ncc(Br)c12,,C1CCOC1,CCOCC,,,val
US20060178418A1,CCN(CC)CC.CCN=C=NCCCN(CC)CC.CN(C)C=O.CN(C)c1ccncc1.Nc1ccncc1.O>>COc1ccc(C(=O)Nc2ccncc2)c2c1[nH]c1ccccc12,CN(C)c1ccncc1,,,Cl,,val
US05747518,C=C(C)c1sccc1NC(=O)OC(C)(C)C.Cl>>C=C(C)c1sccc1N.Cl,,ClCCl,,C1COCCO1,,val
US05708018,CCCN(CCC)C1Cc2ccc(Br)cc2C1.CN(C)C=O>>CCCN(CCC)C1Cc2ccc(C=O)cc2C1,,CCOCC,,CCCCC,[Li]C(C)(C)C,val
US20070027155A1,Clc1cc(Cl)nc(SCc2ccccc2)n1.OB(O)c1ccc(F)c(Cl)c1>>Fc1ccc(-c2cc(Cl)nc(SCc3ccccc3)n2)cc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US04282365,CC(=O)O.N#Cc1ccc2c(c1)C(=O)c1ccccc1OC2>>O=C(O)c1ccc2c(c1)C(=O)c1ccccc1OC2,,O,,Cl,,val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(Br)cc23)cc1.Nc1ccc(N2CCOCC2)cc1>>Brc1ccc2nc(Nc3ccc(N4CCOCC4)cc3)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US20150105367A1,CCC(=O)Cc1ccc(F)c([N+](=O)[O-])c1>>CCC(=O)Cc1ccc(F)c(N)c1,[Pd],CCOC(C)=O,,,,val
US20090023708A1,COC(=O)C1CC(=O)N(c2ccc(O)cc2)C1.ClCCCBr>>COC(=O)C1CC(=O)N(c2ccc(OCCCCl)cc2)C1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05750520,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1cccc(C[C@H](N)C(=O)O)c1>>CC(C)(C)OC(=O)N[C@@H](Cc1cccc(C#N)c1)C(=O)O,,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20050182040A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1ccc(OC2CCC(N3C(=O)c4ccccc4C3=O)CC2)cc1F>>CC(C)(C)OC(=O)NC1CCC(Oc2ccc(C#N)c(F)c2)CC1,,C1CCOC1,CCO,CN,,val
US04571398,NCCCOc1cccc(CN2CCCCC2)c1.S=c1cc[nH]c(=S)[nH]1>>S=c1nc(NCCCOc2cccc(CN3CCCCC3)c2)cc[nH]1,,c1ccncc1,,O,,val
US20030013721A1,Nc1ccccc1Cl.O=C(Cl)CCl>>O=C(CCl)Nc1ccccc1Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05627173,CCOP(=O)(OCC)C(C#N)=Cc1ccc(OC(C)=O)c(OC(C)=O)c1>>CCOP(=O)(OCC)C(C#N)Cc1ccc(OC(C)=O)c(OC(C)=O)c1,[Pd],CC(=O)OC(C)=O,,[H][H],,val
US20020119979A1,CC(C)(C)OC(=O)NCCCC(=O)NC(CCCc1ccccc1)CCCc1ccccc1>>NCCCC(=O)NC(CCCc1ccccc1)CCCc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150232481A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc3nn2c1N1CCC(C)(CC1)OCCCc1cc(F)ccc1COC3>>Cc1nc2cc3nn2c(c1[C@H](OC(C)(C)C)C(=O)O)N1CCC(C)(CC1)OCCCc1cc(F)ccc1COC3,,CCO,,[Na+].[OH-],,val
US20010037037A1,CS(=O)(=O)Cl.CSc1ccc(CO)cc1>>CSc1ccc(COS(C)(=O)=O)cc1,,Cc1ccccc1,,CCN(CC)CC,Cl,val
US20090170908A1,COC(=O)C1CCCC2(CCCC2)C1=O>>COC(=O)C1CCCC2(CCCC2)C1O,O=[Pt],CO,,[H][H],,val
US20130331409A1,Cc1ccnc(Nc2ccc(OCc3ccccc3)cc2)c1N.N#CBr>>Cc1ccnc2c1nc(N)n2-c1ccc(OCc2ccccc2)cc1,,O,,C1CCOC1,O=C([O-])O.[Na+],val
US20150018422A1,BrC(Br)(Br)Br.COc1ccc(COc2ccc(-c3cc(OC)ccc3F)c(CO)c2)cc1>>COc1ccc(COc2ccc(-c3cc(OC)ccc3F)c(CBr)c2)cc1,,Cc1ccccc1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05262568,CCc1cccc(N(C#N)CC)c1.Nc1cccc2ccccc12>>CCc1cccc(N(CC)C(=N)Nc2cccc3ccccc23)c1,,ClCCl,,Cl,,val
US04029787,C=CCNS(=O)(=O)c1cc(C(=O)O)ccc1N1CCN(C)CC1.Cl>>CCCNS(=O)(=O)c1cc(C(=O)O)ccc1N1CCN(C)CC1.Cl,[Pd],C1CCOC1,,[H][H],,val
US20090247538A1,CC(C)(C)c1ccc(CC2(N)CCNCC2)cc1.CCN(CC)CC.CCOC(=O)c1cnc2[nH]ccc2c1Cl>>CCOC(=O)c1cnc2[nH]ncc2c1N1CCC(N)(Cc2ccc(C(C)(C)C)cc2)CC1,,CCCCO,,Cl,,val
US07829155B1,CC(=O)c1ccc(CCCBr)cc1>>CC(O)c1ccc(CCCBr)cc1,,CO,,[BH4-].[Na+],,val
US05403852,COc1ccc(-c2nc(CCCCCC(C#N)C(=O)O)oc2-c2ccc(OC)cc2)cc1>>COc1ccc(-c2nc(CCCCCCC#N)oc2-c2ccc(OC)cc2)cc1,,CCOCC,,O=C=O,,val
US04200754,COC(OC)C(Cl)N=Cc1cccc(Cl)c1>>COC(OC)C(Cl)NCc1cccc(Cl)c1,O=[Pt],CCOC(C)=O,,,,val
US20080004271A1,NO.O=Cc1c(Cl)nc(NC2CC2)nc1Cl>>ON=Cc1c(Cl)nc(NC2CC2)nc1Cl,,CC(=O)O,,Cl,,val
US20130040943A1,CN1C(=O)C=CC1=O.O=C(O)[C@@H]1C[C@H](O)CN1.O=C/C=C/c1ccc(-c2cccc(F)c2)cn1>>CN1C(=O)C2C3CC(O)CN3C(/C=C/c3ccc(-c4cccc(F)c4)cn3)[C@H]2C1=O,,CC#N,,,,val
US20120295884A1,C=CCOc1ccc2[nH]ccc2c1.CN(C)C=O>>C=CCOc1ccc2[nH]cc(C=O)c2c1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US04886814,CC(=O)Nc1nc(C)c(C(=O)CBr)s1.CCOC(=O)c1ccc(CCN)cc1>>CCOC(=O)c1ccc(CCNCC(O)c2sc(NC(C)=O)nc2C)cc1,,CCN(CC)CC,,,,val
US20100267737A1,O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1.O=C(OO)c1cccc(Cl)c1>>O=C(NC/C=C/C[N+]1([O-])CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1,,ClCCl,,,,val
US20110040115A1,COc1ccc(-c2ccc3cc(Br)ccc3c2)cc1C12CC3CC(CC(C3)C1)C2.N#C[Cu]>>COc1ccc(-c2ccc3cc(C#N)ccc3c2)cc1C12CC3CC(CC(C3)C1)C2,,CN(C)C=O,,N,,val
US20070060583A1,CCN(CC)C(=O)c1ccc(F)c([N+](=O)[O-])c1.NCC1CCCCC1>>CCN(CC)C(=O)c1ccc(NCC2CCCCC2)c([N+](=O)[O-])c1,,CCO,,,,val
US20110053972A1,Cn1nccc1-c1cc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)c(Cl)n1C>>Cn1nccc1-c1cc(C(=O)N[C@H](CN)Cc2ccccc2C(F)(F)F)c(Cl)n1C,,C1CCOC1,CO,NN,,val
US05721277,CCO.CCOC=C(C)S(=O)(=O)c1ccc(Cl)cc1.NO>>Cc1oncc1S(=O)(=O)c1ccc(Cl)cc1,,O,,,,val
US05858995,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1oc2c(N)cc(N)cc2c1C>>Cc1oc2c(N)cc(NC(=O)OC(C)(C)C)cc2c1C,,ClCCl,,CCN(CC)CC,,val
US05089044,COC(=O)C(=Cc1ccccc1)Sc1nc(OC)cc(OC)n1>>COc1cc(OC)nc(SC(=Cc2ccccc2)C(=O)O)n1,,O,,CCO,[K+].[OH-],val
US20090209637A1,CCCCCCCCCCCCCCCC(=O)c1c(CCCCCCCCCCCCCCC)oc2cc(O)cc(O)c2c1=O>>CCCCCCCCCCCCCCCc1cc(=O)c2c(O)cc(O)cc2o1,,CO,,[Na+].[OH-],,val
US20040171614A1,C[Si](C)(C)OC[C@@H]1CC[C@H](c2ccccc2)N1S(=O)(=O)c1ccc(Cl)cc1>>O=S(=O)(c1ccc(Cl)cc1)N1[C@@H](CO)CC[C@H]1c1ccccc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20090042929A1,CC(=O)CC(C)=O.NNC(=O)C12CC3CC(CC(C3)C1)C2>>CC(=O)CC(C)=NNC(=O)C12CC3CC(CC(C3)C1)C2,,CCO,,,,val
US20150157622A1,CC(=O)OC(C)=O.CCOC(=O)Oc1c(OC)cc(C(=O)O[C@@H]2C[C@@H]3CN4CCc5c([nH]c6cc(OC(=O)CN)ccc56)[C@H]4C[C@@H]3[C@H](C(=O)OC)[C@H]2OC)cc1OC>>CCOC(=O)Oc1c(OC)cc(C(=O)O[C@@H]2C[C@@H]3CN4CCc5c([nH]c6cc(OC(=O)CNC(C)=O)ccc56)[C@H]4C[C@@H]3[C@H](C(=O)OC)[C@H]2OC)cc1OC,CN(C)c1ccncc1,ClCCl,,,,val
US20090306066A1,C1CC[C@@H]2NCCN[C@@H]2C1.O=C(Cl)OCc1ccccc1>>O=C(OCc1ccccc1)N1CCNC2CCCCC21,,ClCCl,,CCN(CC)CC,,val
US20100160325A1,CC(C)Oc1cc(N)n[nH]1.Clc1ncc(Cl)c(Cl)n1>>CC(C)Oc1cc(Nc2nc(Cl)ncc2Cl)n[nH]1,,C1CCOC1,,CCN(CC)CC,,val
US20100297079A1,CC(C)[Si]1(C(C)C)OC[C@H]2O[C@@H](n3cc(C(N)=O)c4c(N)ncnc43)[C@@H](N=[N+]=[N-])[C@@H]2O[Si](C(C)C)(C(C)C)O1>>[N-]=[N+]=N[C@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cc(C(N)=O)c2c(N)ncnc21,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20070249614A1,CCOP([O-])OCC.COCCOC.O=C(O)CBr.O=C1CCCCC1>>O=C1CC2(CCCCC2)Oc2cc(O)ccc21,,COCCOC,,[H-].[Na+],,val
US20100234351A1,COCCCOCCNC(=O)OC(C)(C)C.Cl>>COCCCOCCN.Cl,,CCO,,,,val
US20090162319A1,CN(C)C(OC(C)(C)C)N(C)C.Cc1cc(Nc2nc(C)c([N+](=O)[O-])c(Nc3c(C)cc(Br)cc3C)n2)ccc1C#N>>Cc1cc(Br)cc(C)c1Nc1nc(Nc2ccc(C#N)cc2)nc(/C=C/N(C)C)c1[N+](=O)[O-],,CN(C)C=O,,,,val
US20020065315A1,Cc1ccc(C)n1-c1c(Br)cc(Cl)cc1Br.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=[N+]([O-])c1cc(Br)c(O)c(Br)c1.OB(O)c1ccccc1>>Cc1ccc(C)n1-c1c(-c2ccccc2)cc(Cl)cc1-c1ccccc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20120101079A1,CCSc1nc(N2CCOCC2)cc(C(F)(F)F)c1C(=O)O.NCc1cccc(F)c1>>CCSc1nc(N2CCOCC2)cc(C(F)(F)F)c1C(=O)NCc1cccc(F)c1,,C1CCOC1,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040077669A1,C#CCOc1cc(Cl)ncn1.Oc1ccc(C(F)(F)F)cc1>>C#CCOc1cc(Oc2ccc(C(F)(F)F)cc2)ncn1,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20110257011A1,CC(=O)Cl.Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=N)NO>>Cc1nc(-c2ccc(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)cc2C)no1,,c1ccncc1,,CCOC(C)=O,O,val
US04241079,COC(=O)NC(=S)NC1=CC=C(C(=O)c2ccccc2)C(Cc2ccccc2[N+](=O)[O-])C1=N.COS(=O)OC>>COC(=O)N=C(NC1=CC=C(C(=O)c2ccccc2)C(Cc2ccccc2[N+](=O)[O-])C1=N)SC,,CN(C)C=O,,O,[H-].[Na+],val
US20070032489A1,COc1nc(C)cc(C)c1C=O.C[PH](c1ccccc1)(c1ccccc1)c1ccccc1>>C=Cc1c(C)cc(C)nc1OC,,Cc1ccccc1,,CC(C)(C)[O-].[K+],,val
US20080242685A1,CCOP(OCC)OCC.O=[N+]([O-])c1cccnc1CBr>>CCOP(=O)(Cc1ncccc1[N+](=O)[O-])OCC,,Cc1ccccc1,,,,val
US20060003998A1,Cl.OC(Cc1ccccc1OC(F)(F)F)(c1ccccc1)C1CN(Cc2ccccc2)CCO1>>Cl.O[C@@](Cc1ccccc1OC(F)(F)F)(c1ccccc1)[C@H]1CNCCO1,[Pd],CC(C)O,,O,,val
US20160176867A1,COC(=O)[C@H](C)NCc1c(F)cccc1F.O=[N+]([O-])c1ccc(Br)cc1F>>C[C@@H](C(=O)O)N(Cc1c(F)cccc1F)c1cc(Br)ccc1[N+](=O)[O-],,CCO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20070275952A1,ClCc1ccnc(Cl)c1.O>>OCc1ccnc(Cl)c1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20030166668A1,CCOC(=O)c1cc(C(=O)OCC)c(C)nc1C>>Cc1nc(C)c(CO)cc1CO,,CCOCC,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20130012544A1,COc1ccc(C2=NN(C3CCN(C(=O)CCl)CC3)C(=O)C2(C)C)cc1OC.O=C1CCC(=O)N1>>COc1ccc(C2=NN(C3CCN(C(=O)CN4C(=O)CCC4=O)CC3)C(=O)C2(C)C)cc1OC,,CC(C)O,,O,O=C([O-])[O-].[K+].[K+],val
US04758585,CCOC(=O)C1CCCCCCC1=O.CCOC(=O)CBr>>CCOC(=O)CC1(C(=O)OCC)CCCCCCC1=O,,Cc1ccccc1,O,[H-].[Na+],,val
US20150111811A1,CC/C=C(\C#CC(C)=O)C(C)(C)C>>CC/C=C(\C=C\C(C)O)C(C)(C)C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040072833A1,CC(C)(C#N)N=NC(C)(C)C#N.COc1ccc(C)c(C)c1>>COc1ccc(CC#N)c(C)c1,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,O=C1CCC(=O)N1Br,,val
US05321002,Cc1c(C(=O)O)cnn1-c1c(Cl)cc(Cl)cc1Cl.NS(N)(=O)=O>>Cc1c(C#N)cnn1-c1c(Cl)cc(Cl)cc1Cl,,O=S1(=O)CCCC1,,O=S(Cl)Cl,,val
US20080292608A1,COC(=O)Cc1ccc(C2CC2)c(O[Si](C)(C)C(C)(C)C)c1>>COC(=O)Cc1ccc(C2CC2)c(O)c1,,C1CCOC1,,Cl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20050261303A1,C[C@H]1CN(C(=O)OC(C)(C)C)[C@H](C)CN1c1ccc(C#N)c(F)c1>>C[C@H]1CN[C@H](C)CN1c1ccc(C#N)c(F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04965270,CC1(C)OC[C@@H](CON)O1.O=CNc1nc(Cl)c(NC=O)c(Cl)n1>>CC1(C)OC[C@@H](CONc2nc(NC=O)nc(Cl)c2NC=O)O1,,COCCOCCOC,,CCN(C(C)C)C(C)C,,val
US04460596,CCOC(=O)Cc1nc(-c2ccc(F)cc2)oc1-c1cccs1>>O=C(O)Cc1nc(-c2ccc(F)cc2)oc1-c1cccs1,,O,,CO,[K+].[OH-],val
US20120041012A1,CCOC(=O)c1cc(OCC)c(-c2ccc(F)cc2)c(OCC)c1>>CCOc1cc(CO)cc(OCC)c1-c1ccc(F)cc1,,C1CCOC1,,[Li],,val
US20080269193A1,CC(C)(C)OC(=O)NCC(=O)O.Cc1nn(-c2cc(F)c(C(N)=O)c(N[C@@H]3CC[C@@H](O)CC3)c2)c2c1C(=O)CC(C)(C)C2>>Cc1nn(-c2cc(F)c(C(N)=O)c(N[C@@H]3CC[C@@H](OC(=O)CNC(=O)OC(C)(C)C)CC3)c2)c2c1C(=O)CC(C)(C)C2,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20030003049A1,CCc1cc(-c2ccc(F)cc2)c(OCc2ccccc2)cc1OCCCCCC(C)(C)C#N>>CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)CN,O=[Pt],CCO,,[H][H],,val
US20130059853A1,COCOc1c(-c2cccc3c2CCC3=O)ccc(OC)c1OC>>COc1ccc(-c2cccc3c2CCC3=O)c(O)c1OC,,CO,,Cl,,val
US08901145B2,CS(=O)(=O)c1nccc(/C=C2\SC(=O)NC2=O)n1.N=C(c1ccco1)N1CCNCC1>>N=C(c1ccco1)N1CCN(c2nccc(/C=C3\SC(=O)NC3=O)n2)CC1,,CS(C)=O,,CCN(C(C)C)C(C)C,Cl,val
US05250274,O=[Cr](=O)([O-])[O-].O=[Cr](=O)([O-])[O-].[Na+].[Na+]>>O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].[Na+].[Na+],,O,,,,val
US05480899,O=Cc1ccc(O)cc1.O=[N+]([O-])c1cccc(S(=O)(=O)OC[C@H]2CO2)c1>>O=Cc1ccc(OC[C@H]2CO2)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120115869A1,CCC(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1cccc(C#N)c1.[N-]=[N+]=[N-]>>CCC(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1cccc(-c2nnn[nH]2)c1,O=[Cu-],CN(C)C=O,CO,,,val
US20090176786A1,CCNC(=O)N(C)c1ccc(SC(F)(F)F)cc1F.O=C(Cl)c1c(F)cccc1F>>CCN(C(=O)c1c(F)cccc1F)C(=O)N(C)c1ccc(SC(F)(F)F)cc1F,,c1ccncc1,,CCOC(C)=O,O,val
US20090291917A1,CN(CCO[Si](C)(C)C(C)(C)C)c1nc(Oc2ccc(B3OC(C)(C)C(C)(C)O3)c(C=O)c2)ccc1C#N>>CN(CCO)c1nc(Oc2ccc3c(c2)COB3O)ccc1C#N,,CO,,Cl,[BH4-].[Na+],val
US07465808B2,C1CCOC1.CCOC(=O)C(CC#CC(=O)c1ccc(Br)cc1)c1cccc(C)c1.CCOC(C)=O.NN>>CCOC(=O)C(Cc1cc(-c2ccc(Br)cc2)n(-c2ccc(C)cc2)n1)c1cccc(C)c1,,C1CCOC1,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040224958A1,CCNc1nc(Nc2ccccc2)ncc1C=O.CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CCNc1nc(Nc2ccccc2)ncc1C=CC(=O)OCC,,C1CCOC1,,,,val
US20150299179A1,CC(C)Oc1ccc(-c2nnc(-c3cccc4c3CCC[C@H]4N(CC(=O)O)C(=O)OC(C)(C)C)s2)cc1C#N>>CC(C)Oc1ccc(-c2nnc(-c3cccc4c3CCC[C@H]4NCC(=O)O)s2)cc1C#N,,C1COCCO1,,,,val
US20160075657A1,CC(C)(C)OC(=O)N1Cc2ccc(OCc3ccccc3)cc2C(O)C1>>CC(C)(C)OC(=O)N1CC(=O)c2cc(OCc3ccccc3)ccc2C1,,ClCCl,O,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US04182769,Fc1ccc(-c2nc[nH]c2-c2ccc(F)cc2)cc1.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(c1ccccc1)n1cnc(-c2ccc(F)cc2)c1-c1ccc(F)cc1,,COCCOC,,CC(C)(C)[O-].[K+],,val
US20090270412A1,C=O.CNCCc1cn(CCc2ccc(C)nc2)c2ccc(C)cc12>>Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CN(C)CC1,,CC#N,,O=C(O)C(F)(F)F,,val
US20090291917A1,N#Cc1ccc(Cl)nc1OCCOC1CCCCO1.O=Cc1cc(O)ccc1Br>>N#Cc1ccc(Oc2ccc(Br)c(C=O)c2)nc1OCCOC1CCCCO1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06211234B1,C=C(NC(=O)c1ccc(OCc2ccsc2)cc1OC(CCC(=O)OCC)c1ccccc1C)C(=O)OC>>C=C(NC(=O)c1ccc(OCc2ccsc2)cc1OC(CCC(=O)O)c1ccccc1C)C(=O)O,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150158865A1,CN(C(=O)N[C@@H]1CCCN(c2cnc(C#N)c(Cl)n2)C1)c1cc(Cl)cc(C(F)(F)F)c1.NC1CC1>>CN(C(=O)N[C@@H]1CCCN(c2cnc(C#N)c(NC3CC3)n2)C1)c1cc(Cl)cc(C(F)(F)F)c1,,CCOC(C)=O,CN1CCCC1=O,,,val
US20020086890A1,CC#CCOc1ccc(S(=O)(=O)C2(C(=O)NO)CCNCC2)cc1.COC(=O)c1ccc(CBr)cc1.Cl>>CC#CCOc1ccc(S(=O)(=O)C2(C(=O)NO)CCN(Cc3ccccc3C(=O)OC)CC2)cc1.Cl,,CCOCC,CO,CCN(CC)CC,Cl,val
US20070238730A1,CCc1noc(CCNC(=O)OC(C)(C)C)n1.Cl>>CCc1noc(CCN)n1.Cl,,ClCCl,,,,val
US20140045872A1,Cc1ccncc1I.O=C1NCCc2cc(F)ccc21>>Cc1ccncc1N1CCc2cc(F)ccc2C1=O,I[Cu]I,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20130023519A1,COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1N.Cc1ccc(S(=O)(=O)Cl)o1>>COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccc(C)o1,,ClCCl,,O,c1ccncc1,val
US20080194617A1,CCOC(CBr)OCC.Cc1nn(C)c(-n2ccc3cc(Cl)ccc32)c1CO>>CCOC(COCc1c(C)nn(C)c1-n1ccc2cc(Cl)ccc21)OCC,,CN(C)C=O,,O,[H-].[Na+],val
US20070185104A1,N#CCC(=O)O.ONc1ccccc1>>N#CCC(=O)Nc1ccccc1O,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20070105919A1,C1COCCN1.CC(C)(C)OC(=O)Nc1nc(-c2ccco2)c(C(=O)C2CCCC2)s1>>O=C(c1sc(NC(=O)N2CCOCC2)nc1-c1ccco1)C1CCCC1,,C1COCCO1,,,,val
US20020193578A1,CO.COC(=O)c1ccc(C#Cc2cc(C3CC3)c3c(c2)C(C)(C)CC2(CC2)O3)cc1F>>CC1(C)CC2(CC2)Oc2c(C3CC3)cc(C#Cc3ccc(CC(=O)O)c(F)c3)cc21,,CC#N,,O,[Na+].[OH-],val
US20040058978A1,COC(=C1C(=O)N(C(C)=O)c2ccc([N+](=O)[O-])cc21)c1ccccc1.Nc1ccc([N+](=O)[O-])cc1>>O=C1Nc2ccc([N+](=O)[O-])cc2/C1=C(/Nc1ccc([N+](=O)[O-])cc1)c1ccccc1,,CN(C)C=O,,N,,val
US06002008,N#Cc1cnc2ccc([N+](=O)[O-])cc2c1Nc1cccc(I)c1>>N#Cc1cnc2ccc(N)cc2c1Nc1cccc(I)c1,,CCO,,,,val
US04314061,CCN(CC)CCOc1ccc2cc3ccc(OCCN(CC)CC)cc3nc2c1.[Cl-].[Cl-].[Zn+2]>>CCN(CC)CCOc1ccc2cc3ccc(OCCN(CC)CC)cc3nc2c1.[Cl-].[Cl-].[Zn+2],,CCO,,,,val
US20160083422A1,CC(C)(C)C(=O)Cl.OCCO>>CC(C)(C)C(=O)OCCO,,O,,CCN(CC)CC,,val
US20150232435A1,CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.O=C(O)c1cn2ccncc2n1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cn4ccncc4n3)CC2)cc(C(F)(F)F)n1,,CO,ClC(Cl)Cl,,,val
US20100121049A1,O=c1[nH]c2c(c3ccccc13)Cc1c(CBr)cccc1-2>>O=C1N=CC=c2ccc3c(c21)C=c1ccccc1=3,,CCO,,CN(C)C=O,,val
US05952368,Cn1cccc1Cc1ccc([N+](=O)[O-])cc1>>Cn1cccc1Cc1ccc(N)cc1,[Pd],CCOC(C)=O,,,,val
US05306816,C=CCOC(=O)C1=C(SC)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12.OO>>C=CCOC(=O)C1=C(S(C)=O)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12,,CCO,ClCCl,,,val
US20040127527A1,CNC.COC(=O)c1ccc(CBr)nc1>>COC(=O)c1ccc(CN(C)C)nc1,,C1CCOC1,,O,,val
US06960575B2,COCC(=O)N1C=C(c2ccccc2)N(CC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)C(=O)C1C(C)C.Cl>>COCC(=O)N1C=C(c2ccccc2)N(CC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCNCC2)C(=O)C1C(C)C.Cl,,CCOC(C)=O,,,,val
US20130109670A1,CC(C)(C)OC(=O)N1CC(Nc2nc(-c3ccc(NC(=O)Nc4ccccc4)cc3)nc(N3CCOCC3)n2)C1>>O=C(Nc1ccccc1)Nc1ccc(-c2nc(NC3CNC3)nc(N3CCOCC3)n2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140031342A1,C(=C1CCN(c2ccc(OC3CCCCO3)cc2)CC1)c1ccc(OCc2ccccc2)cc1>>Oc1ccc(CC2CCN(c3ccc(OC4CCCCO4)cc3)CC2)cc1,[Pd],CCOC(C)=O,,CCO,,val
US20110039843A1,CC(=O)OC(C)=O.Nc1cnccc1-c1nc2cc(C(F)(F)F)ccc2o1>>CC(=O)Nc1cnccc1-c1nc2cc(C(F)(F)F)ccc2o1,,O,,,,val
US20090142297A1,NCc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1cc2ccccc2s1>>O=C1CCC(N2C(=O)c3ccc(CNC(=O)c4cc5ccccc5s4)cc3C2=O)C(=O)N1,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20140363452A1,CO[C@H]([C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC(C)(C)C)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21>>CO[C@H]([C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC(C)(C)C)[C@@H]1CCCN1,,ClCCl,,CCNCC,,val
US05212320,CCOC(=O)CCCn1cc(C(=O)c2cccc([N+](=O)[O-])c2)c2cc(Cl)ccc21>>O=C(O)CCCn1cc(C(=O)c2cccc([N+](=O)[O-])c2)c2cc(Cl)ccc21,,C1COCCO1,,CO,[Na+].[OH-],val
US20160207939A1,C[C@@H](CC=O)NC(=O)OC(C)(C)C.NC1CC1>>C[C@@H](CCNC1CC1)NC(=O)OC(C)(C)C,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060128635A1,COc1ccc(-c2c(Br)c(OCc3ccccc3)nn2C(C)C)cc1.COc1ccc(C=O)c(OC)c1>>COc1ccc(-c2c(Cc3ccc(OC)cc3OC)c(=O)[nH]n2C(C)C)cc1,,C1CCOC1,,[Li]CCCC,,val
US20150336960A1,CS(=O)(=O)OCc1ccc(-c2c(F)cc(OC3CCOCC3)cc2F)nn1.[N-]=[N+]=[N-]>>[N-]=[N+]=NCc1ccc(-c2c(F)cc(OC3CCOCC3)cc2F)nn1,,CN(C)C=O,,O,,val
US20120302539A1,CC(C)(C)OC(=O)NC1CCNCC1.O=S(=O)(Cl)c1ccc(CBr)cc1>>CC(C)(C)OC(=O)NC1CCN(S(=O)(=O)c2ccc(CBr)cc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080161280A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2cccc(Cc3n[nH]c(=O)c4c3CCCC4)c2)CC1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C(c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)N1CCNCC1,,ClCCl,,,,val
US20110065765A1,CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.C[C@H](Cl)OC(=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@H]12>>CCCCc1nc(Cl)c(C(=O)O[C@H](C)OC(=O)O[C@H]2CO[C@@H]3[C@H](O[N+](=O)[O-])CO[C@H]23)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,CN(C)C=O,CO,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070167485A1,CC#N.CC(C)(C)O.CCOC(=O)c1cnc2c(cnn2CC)c1Cl>>CCOC(=O)c1cnc2c(cnn2CC)c1NC(C)(C)C,,CC#N,,CCN(C(C)C)C(C)C,,val
US05891871,CN=C=O.O=C1Cc2cc3c(cc2C(c2ccccc2)=NN1)OCO3>>CNC(=O)N1N=C(c2ccccc2)c2cc3c(cc2CC1=O)OCO3,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20080188454A1,NN.O=C(O)CC1CCCc2ccccc2C1=O>>O=C1CC2CCCc3ccccc3C2=NN1,,CCO,,O,,val
US08710086B2,CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1c1ccc(CCl)c(F)c1.CCNCC>>CCN(CC)Cc1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,,Cc1ccccc1,,,,val
US20160052939A1,COC(=O)c1cccc(C)c1-c1ncc(F)cn1>>Cc1cccc(C(=O)O)c1-c1ncc(F)cn1,,CO,,[Na+].[OH-],,val
US05952327,CCN(CC)CC.CCOC(=O)CN1C(=O)[C@@H](NC(=O)C2(CP(=O)(OCC)OCC)CCCC2)CCc2ccccc21.C[Si](C)(C)Br>>CC([NH3+])c1ccccc1.CCOC(=O)CN1C(=O)[C@@H](NC(=O)C2(CP(=O)(O)O)CCCC2)CCc2ccccc21,,CC(C)=O,ClCCl,,,val
US20100113422A1,O=C(O)/C=C/C(=O)O.c1ccc(Cc2ncc3c(n2)CCNCC3)cc1>>O=C(O)/C=C/C(=O)O.c1ccc(Cc2ncc3c(n2)CCNCC3)cc1,,CCOC(C)=O,CO,,,val
US20060223826A1,CC(=O)c1ccc(CCl)cc1N.CNC>>CC(=O)c1ccc(CN(C)C)cc1N,,ClC(Cl)Cl,,Cl,,val
US04046903,ClP(Cl)Cl.O=C(O)CO[c-]1cccc1.[Fe+2].c1cc[cH-]c1>>O=C(Cl)CO[c-]1cccc1.[Fe+2].c1cc[cH-]c1,c1ccncc1,c1ccccc1,,,,val
US20090105253A1,CC(C)(C)OC(=O)OC(C)(C)C.Nc1ccc(N)cc1>>CC(C)(C)OC(=O)Nc1ccc(N)cc1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20160184318A1,Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCN(CC(=O)OC(C)(C)C)C[C@H]2C)n1>>Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCN(CC(=O)O)C[C@H]2C)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080293742A1,COc1nc([N+](=O)[O-])cnc1NS(=O)(=O)c1cccc(Cl)c1F>>COc1nc(N)cnc1NS(=O)(=O)c1cccc(Cl)c1F,[Fe],CCO,O,[Cl-].[NH4+],,val
US20060058338A1,CCOC(=O)C1CCN(c2cc3cccnc3c(-c3cccc(SC)c3)n2)CC1>>CSc1cccc(-c2nc(N3CCC(C(=O)O)CC3)cc3cccnc23)c1,,C1CCOC1,,[Na+].[OH-],,val
US20160002228A1,Nc1ncccc1C1CC1.O=C1CCC(=O)N1Br>>Nc1ncc(Br)cc1C1CC1,,CC#N,,,,val
US20060183732A1,O=C1c2ccccc2C(=O)N1[C@H]1CC=C[C@@H](c2ccccc2)N(C2CCCC2)C1=O>>N[C@H]1CC=C[C@@H](c2ccccc2)N(C2CCCC2)C1=O,,CO,,NN,O,val
US20150218173A1,CCOC(=O)Cl.Cc1cn(S(=O)(=O)c2ccccc2)c2ncnc(Cl)c12>>CCOC(=O)c1c(C)c2c(Cl)ncnc2n1S(=O)(=O)c1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20090209607A1,Cn1nccc1-c1sc(C(=O)O)cc1Br.O=C1CCC(=O)N1Cl>>Cn1ncc(Cl)c1-c1sc(C(=O)O)cc1Br,,C1CCOC1,,,,val
US20070010542A1,Nc1ccc(F)cc1N.S=C=S>>Fc1ccc2[nH]c(S)nc2c1,,CO,,,,val
US20070249642A1,O=C(c1ccccc1)n1c(=O)c(-c2cccnc2)cn(CCCCl)c1=O>>O=c1[nH]c(=O)n(CCCCl)cc1-c1cccnc1,,CO,N,,,val
US20150148313A1,CCOC(=O)C(F)(F)Br.Cc1cc(Br)cc(C)c1I>>CCOC(=O)C(F)(F)c1c(C)cc(Br)cc1C,[Cu],CS(C)=O,,,,val
US20150284385A1,N#Cc1ccn2c3c(nc2c1)C[C@H](c1cc(F)c(F)cc1F)[C@@H](NC(=O)[C@H](O)c1ccccc1)C3>>N#Cc1ccn2c3c(nc2c1)C[C@H](c1cc(F)c(F)cc1F)[C@@H](N)C3,,Cl,,O=C([O-])[O-].[Na+].[Na+],,val
US20150246934A1,CCOC(=O)CS.CN(C(=O)OC(C)(C)C)c1cc(F)cc2c1[nH]c1nc(Oc3cnc(S(C)(=O)=O)nc3)nc(S(=O)(=O)Cc3ccccc3)c12.NCCCCN>>CN(C(=O)OC(C)(C)C)c1cc(F)cc2c1[nH]c1nc(Oc3cnc(SCC(=O)O)nc3)nc(NCCCCN)c12,,CN1CCCC1=O,,[Na+].[OH-],,val
US04874775,CSc1ccc(NCc2cccnc2)cc1.O=S(=O)(Cl)CCl>>CSc1ccc(N(Cc2cccnc2)S(=O)(=O)CCl)cc1,,ClCCl,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20080039426A1,CP1(=O)CCC(C(=O)OCc2ccccc2)(C(=O)OCc2ccccc2)CC1>>CP1(=O)CCC(C(=O)O)(C(=O)O)CC1,[Pd],CCO,,[H][H],,val
US20090247567A1,COC(=O)c1ccc2c(c1)-c1sc(-c3nncn3-c3ccc(F)cc3F)cc1CCO2>>O=C(O)c1ccc2c(c1)-c1sc(-c3nncn3-c3ccc(F)cc3F)cc1CCO2,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20060135578A1,CCOP(=O)(CP(=O)(OCC)OCC)OCC.COc1cc(COc2cc(C=O)n(-c3ccccc3)n2)ccc1OCc1nc(-c2ccco2)oc1C>>CCOP(=O)(/C=C/c1cc(OCc2ccc(OCc3nc(-c4ccco4)oc3C)c(OC)c2)nn1-c1ccccc1)OCC,,O,,CN(C)C=O,[H-].[Na+],val
US05356897,Fc1ccc(-c2nn3cccnc3c2-c2ccncc2)cc1>>Fc1ccc(-c2nn3c(c2-c2ccncc2)NCCC3)cc1,,CCO,,[BH4-].[Na+],,val
US20120115813A1,CC1OB(c2c(C=O)cc(Cl)cc2OCCCOCc2ccccc2)OC1(C)C.C[N+](=O)[O-]>>O=[N+]([O-])CC1OB(O)c2c(OCCCOCc3ccccc3)cc(Cl)cc21,,C1CCOC1,CCOC(C)=O,Cl,[Na+].[OH-],val
US20090197834A1,CC(C)n1cc(N)c(=O)c2cc(F)c(NC3CCCCC3)cc21.CCOC(=O)NS(=O)(=O)c1ccc(Cl)s1>>CC(C)n1cc(NC(=O)NS(=O)(=O)c2ccc(Cl)s2)c(=O)c2cc(F)c(NC3CCCCC3)cc21,,Cc1ccccc1,,,,val
US20120068170A1,CC1(C)c2ccccc2-c2cc3c(cc21)[nH]c1ccc(Br)cc13.Clc1nc(-c2ccccc2)nc(-c2ccccc2)n1>>CC1(C)c2ccccc2-c2cc3c4cc(Br)ccc4n(-c4nc(-c5ccccc5)nc(-c5ccccc5)n4)c3cc21,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20120202788A1,CC(C)(C)OC(=O)Nc1nccc2nc(-c3c(Cl)cc(C#N)cc3Cl)sc12.ClCCl.N#Cc1cc(Cl)c(-c2nc3ccnc(N)c3s2)c(Cl)c1.O=C(O)C(F)(F)F>>Cc1cc(Nc2nccc3nc(-c4c(Cl)cc(C#N)cc4Cl)sc23)nc(N)n1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20040254215A1,CC=[N+]=CC.CCCCOC(=O)c1ncc2cc(Sc3ccccc3)ccc2c1O>>CCCCOC(=O)c1nc(CN(C)C)c2cc(Sc3ccccc3)ccc2c1O,,ClCCl,,[I-].[K+],,val
US20070265264A1,Cc1ccc(O)cn1.O=[N+]([O-])c1ccc(F)c(Cl)c1>>Cc1ccc(Oc2ccc([N+](=O)[O-])cc2Cl)cn1,,CC(C)=O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20050080108A1,COC(=O)c1cc2cc([N+](=O)[O-])ccc2o1>>COC(=O)c1cc2cc(N)ccc2o1,[Pd],C1CCOC1,,[H][H],,val
US20110034492A1,CN(C(=S)Cl)c1ccccc1.Nc1nc(O)ncc1F>>CN(C(=S)n1cc(F)c(N)nc1=O)c1ccccc1,,ClCCl,,CC#N,,val
US20100137282A1,C=CCN(C(=O)C(C)(C)C)c1nc(Cl)ccc1Br.CO>>C=CCN(C(=O)C(C)(C)C)c1nc(OC)ccc1Br,,CO,,O,C[O-].[Na+],val
US20080161341A1,CCOC(=O)[C@@H]1C[C@H]1c1nnc2ccc(-c3c(-c4ccc(F)cc4)nc4occn34)cn12>>O=C(O)[C@@H]1C[C@H]1c1nnc2ccc(-c3c(-c4ccc(F)cc4)nc4occn34)cn12,,C1COCCO1,,[Na+].[OH-],,val
US04994489,CCOP(=O)(OCC)C(Cl)c1ccc2c(c1)C(C)(C)CCC2(C)C.O=Cc1ccc(C(=O)O)cc1>>CC1(C)CCC(C)(C)c2cc(C#Cc3ccc(C(=O)O)cc3)ccc21,,CS(C)=O,,O=S(=O)(O)O,,val
US08623880B2,CC(C)(C)COc1ccc(-c2csc(NC(=O)CBr)n2)cc1Cl.Cc1c2c(=O)n(C)c(=O)n(C)c2nn1C>>Cc1cc2c(c(=O)n(C)c(=O)n2C)n1CC(=O)Nc1nc(-c2ccc(OCC(C)(C)C)c(Cl)c2)cs1,,CN(C)C=O,,[H-].[Na+],,val
US20080318963A1,CCOC(=O)Cl.COc1nc2cc(Cl)c(Cl)cc2nc1N>>CCOC(=O)Nc1nc2cc(Cl)c(Cl)cc2nc1OC,,ClCCl,,c1ccncc1,,val
US20080167353A1,O=C1CCC(=O)N1I.O=C1OCc2c1cc1ccc3c(c1c2-c1ccc2c(c1)OCO2)OCO3>>O=C1OCc2c1cc1c(I)cc3c(c1c2-c1ccc2c(c1)OCO2)OCO3,,CC#N,,O=S(=O)(O)O,,val
US20150210682A1,CCOC=O.COc1cc(CC(C)N)ccc1C>>COc1cc(CC(C)NC=O)ccc1C,,CCO,,CCN(CC)CC,,val
US04902835,CCCCCC[Mg]Br.COC(F)(F)C(F)=CCBr>>CCCCCCCC=C(F)C(F)(F)OC,,C1CCOC1,CCOCC,[Cl-].[NH4+],,val
US20150031668A1,CC(C)(C)[S@@](=O)N[C@]1(c2ccc(OC(F)(F)F)c(F)c2)CCOc2cccnc21.Cl>>Cl.N[C@]1(c2ccc(OC(F)(F)F)c(F)c2)CCOc2cccnc21,,C1COCCO1,ClCCl,,,val
US20120264785A1,CC#N.CCC(F)(F)C(=O)OC>>CCC(F)(F)C(=O)CC#N,,C1CCOC1,,[Li]CCCC,,val
US06054614,CN.O=C1CCCc2ccccc21>>CNc1cccc2ccccc12,Cl[Ti](Cl)(Cl)Cl,Cc1ccccc1,ClCCl,C1CCOC1,,val
US20120184553A1,Cn1cc(N)cn1.O=C(O)c1cc(Br)ccc1OCc1ccccc1>>Cn1cc(NC(=O)c2cc(Br)ccc2OCc2ccccc2)cn1,,CN(C)C=O,O,ClCCCl,On1nnc2ccccc21,val
US20020128301A1,CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O.COc1ccc(COC(=O)[C@H](C)O)cc1>>COc1ccc(COC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04256640,CN.Cn1c2c(c3ccccc31)C(C)(C=O)CCS2>>CN=CC1(C)CCSc2c1c1ccccc1n2C,,CO,c1ccccc1,,,val
US06358973B1,CC(C)Br.COc1cccc(CC#N)c1>>COc1cccc(C(C#N)C(C)C)c1,,CN(C)C=O,,[H-].[Na+],,val
US20100179148A1,CCOC(=O)Nc1cccc(Cn2nc(C(N)=S)ccc2=O)c1.O=C(CBr)c1ccncc1>>CCOC(=O)Nc1cccc(Cn2nc(-c3nc(-c4ccncc4)cs3)ccc2=O)c1,,CCO,,Br,,val
US05446152,C1COOOC1.CCN(CC)CCCNC(=O)c1cc(Cl)ccc1O>>CCN(CC)CCCN1COc2ccc(Cl)cc2C1=O,,O=C(O)C(F)(F)F,,,,val
US20020173518A1,CC(C)(C)c1ccc(C(=O)Nc2ccccc2NC(=O)c2ccc3cc[nH]c3c2)cc1>>CC(C)(C)c1ccc(C(=O)Nc2ccccc2NC(=O)c2ccc3c(c2)NCC3)cc1,,CC(=O)O,O,[BH3-]C#N.[Na+],,val
US20100197683A1,C1COCCN1.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCCOS(C)(=O)=O)CC2)c2ncnn12>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCCN3CCOCC3)CC2)c2ncnn12,,C1CCOC1,,[I-].[Na+],,val
US20110201643A1,COCCCOC(=O)N1CCc2cc(C(=O)NOC3CCCCO3)ccc2C1>>COCCCOC(=O)N1CCc2cc(C(=O)NO)ccc2C1,,CO,Cl,,,val
US20150175594A1,Cc1noc(-c2c(NC(=O)C3=C(C(=O)O)CCCC3)sc3c2CCOC3)n1.O=C1OC(=O)C2=C1C1CCC2CC1>>Cc1noc(-c2c(NC(=O)C3=C(C(=O)O)C4CCC3CC4)sc3c2CCOC3)n1,,CCOCC,ClCCl,,,val
US20090118282A1,CC(C)(C)OC(=O)N1CCNCC1.O=Cc1ccc(O)cc1>>CC(C)(C)OC(=O)N1CCN(Cc2ccc(O)cc2)CC1,,CO,,[BH3-]C#N.[Na+],,val
US20080090840A1,CCC(COc1ccc([C@H](CC(=O)N2C(=O)OC[C@@H]2Cc2ccccc2)c2ccon2)cc1)Oc1ccc(C(F)(F)F)cc1.OO>>CCC(COc1ccc([C@H](CC(=O)O)c2ccon2)cc1)Oc1ccc(C(F)(F)F)cc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US04017546,COc1ccc(C(=O)C2=C(c3ccccc3)c3ccc(OC)cc3CC2)cc1>>COc1ccc(C(=O)c2ccc3cc(OC)ccc3c2-c2ccccc2)cc1,,c1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20040006081A1,C=CCBr.Clc1ccc(Cc2ccncc2)cc1>>C=CC(c1ccncc1)c1ccc(Cl)cc1,,C1CCOC1,,[Li]CCCC,,val
US20120009151A1,O=S(=O)(c1ccccc1)N1CCC(Nc2nc(Cl)nc(N3CCCC3)n2)CC1.OCC(F)(F)F>>O=S(=O)(c1ccccc1)N1CCC(Nc2nc(OCC(F)(F)F)nc(N3CCCC3)n2)CC1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US06030952,COC(=O)C=Cc1ccc2c(c1)C(C)(c1ccc3c(c1)C(C)(C)CCC3(C)C)CO2>>CC1(C)CCC(C)(C)c2cc(C3(C)COc4ccc(C=CC(=O)O)cc43)ccc21,,C1CCOC1,,Cl,[Na+].[OH-],val
US20090062258A1,CCOC(C)=O.CSCS(C)=O.O=Cc1scc2[nH]c(=O)n(-c3cccc(S(=O)(=O)N4CCCc5ccccc54)c3)c(=O)c12>>COC(=O)Cc1scc2[nH]c(=O)n(-c3cccc(S(=O)(=O)N4CCCc5ccccc54)c3)c(=O)c12,,CCOC(C)=O,,C1CCOC1,,val
US20130331409A1,C[Si](C)(C)CCOCn1c(Cl)nc2ccccc21.Oc1ccc(-c2cccn3ccnc23)cc1>>C[Si](C)(C)CCOCn1c(Oc2ccc(-c3cccn4ccnc34)cc2)nc2ccccc21,,CN(C)C=O,,O,[H-].[Na+],val
US20150225354A1,CN(C)C(OC(C)(C)C)OC(C)(C)C.Cc1ccc(OCc2ccccc2)cc1C1=NOC(CC(=O)O)(C(=O)O)C1>>Cc1ccc(OCc2ccccc2)cc1C1=NOC(CC(=O)OC(C)(C)C)(C(=O)OC(C)(C)C)C1,,Cc1ccccc1,,,,val
US20090124682A1,CC(OC[C@@H]1c2ccccc2C[C@H]1NC(=O)O[Si](C)(C)C(C)(C)C)C(=O)OC(C)(C)C>>CC(OC[C@@H]1c2ccccc2C[C@H]1N)C(=O)OC(C)(C)C,,C1CCOC1,,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20100280011A1,CC(C)(C)OC(=O)NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(OCC(=O)c2ccccc2)cc1.Cl.ClCCl>>Cl.Cl.NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(OCC(=O)c2ccccc2)cc1,,ClCCl,,,,val
US20090247500A1,Cc1cnc(N)s1.O=C(O)c1cc(Cl)ccc1Cl>>Cc1cnc(NC(=O)c2cc(Cl)ccc2Cl)s1,,C1CCOC1,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US20160168101A1,CCCC[Sn](CCCC)(CCCC)c1ccnn1-c1ccc(C#N)cc1.CCOc1nc(Br)c(C)n1-c1cccc(C(F)(F)F)c1>>CCOc1nc(-c2ccnn2-c2ccc(C#N)cc2)c(C)n1-c1cccc(C(F)(F)F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US05891916,CCOC(=O)CCCCCC(C#N)(c1ccc(OC)cc1)c1ccc(OC)cc1>>CCOC(=O)CCCCCC(C#N)(c1ccc(O)cc1)c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,,val
US20080004323A1,Cc1ccccc1.O=S(=O)(NC(=S)C=Cc1ccccc1)c1ccccc1.O=S(Cl)Cl>>O=S(=O)(N=C(C=CSc1ccccc1)Sc1ccccc1)c1ccccc1,CN(C)C=O,CCN(CC)CC,,,,val
US20100004238A1,Cn1ccc2c(Oc3ccc(N)cc3Cl)ncnc21.O=C(OCCn1ccc2ncnc(Cl)c21)c1ccccc1>>Cn1ccc2c(Oc3ccc(Nc4ncnc5ccn(CCO)c45)cc3Cl)ncnc21,,CN1CCCC1=O,,,,val
US20050153968A1,Cc1c(N2C(=O)C(CNC(=O)OC(C)(C)C)N(C)C2=O)ccc(C#N)c1Cl>>C=C1C(=O)N(c2ccc(C#N)c(Cl)c2C)C(=O)N1C,,ClCCl,O=C(O)C(F)(F)F,,,val
US20130096113A1,COc1cc2ncn(Cc3ccc4nc(Br)sc4c3)c2cc1OC.NCC1CCCCC1>>COc1cc2ncn(Cc3ccc4nc(NCC5CCCCC5)sc4c3)c2cc1OC,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20100029478A1,COC(=O)c1cc(CO)nn1-c1ncccc1Cl.CS(=O)(=O)Cl>>COC(=O)c1cc(COS(C)(=O)=O)nn1-c1ncccc1Cl,,ClCCl,,CCN(CC)CC,,val
US04824859,CCN(CC)CCOc1ccc(NC2=NN(c3ccccc3)CC2)cc1.O=C=Nc1ccccc1>>CCN(CC)CCOc1ccc(N(C(=O)Nc2ccccc2)C2=NN(c3ccccc3)CC2)cc1,,C1CCOC1,,,,val
US20120225909A1,CC(C)(C)OC(=O)n1nc(Cl)c2ccc(OCCN(Cc3ccccc3)C[C@H](O)c3ccc(Cl)c([N+](=O)[O-])c3)cc21>>CC(C)(C)OC(=O)n1nc(Cl)c2ccc(OCCN(Cc3ccccc3)C[C@H](O)c3ccc(Cl)c(N)c3)cc21,,C1CCOC1,CO,,,val
US20100087427A1,CC(C)(C)OC(=O)N1C[C@H](CNc2ccc(Cl)cc2)[C@@H](Cc2ccccc2)C1.N#Cc1cccc2ccc(CBr)cc12>>N#Cc1cccc2ccc(CN(C[C@H]3CNC[C@@H]3Cc3ccccc3)c3ccc(Cl)cc3)cc12,,O,,CC#N,CC#N,val
US20040106667A1,CC(C)(C)OC(=O)n1nc(I)c2cc(NS(=O)(=O)c3ccccc3S(C)(=O)=O)ccc21.CN(C)c1ccc(B(O)O)cc1>>CN(C)c1ccc(-c2n[nH]c3ccc(NS(=O)(=O)c4ccccc4S(C)(=O)=O)cc23)cc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20060025445A1,NCC(=O)c1ccc(C(F)(F)F)cc1.O=S(=O)(Cl)c1ccccc1>>O=C(CNS(=O)(=O)c1ccccc1)c1ccc(C(F)(F)F)cc1,,CN(C)C=O,O,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US05167949,N#Cc1nccnc1N.N=C(N)COc1ccc(Cl)c(Cl)c1>>Nc1nc(COc2ccc(Cl)c(Cl)c2)nc2nccnc12,,CCO,,CN(C)C=O,,val
US20090042890A1,CCOC(=O)c1nc(NC[C@@H]2CCCN2C(=O)OC(C)(C)C)nc(Nc2ccccc2OC)c1N.CCOC(=O)c1nc(NC[C@@H]2CCCN2C(=O)OC(C)(C)C)nc2c1[nH]c(=O)n2-c1ccccc1OC>>COc1ccccc1-n1c(=O)[nH]c2c(C(N)=O)nc(NC[C@@H]3CCCN3)nc21,,ClCCl,,,,val
US20090054475A1,CC(C)(C)OC(=O)N1CCCC(c2nc(CCl)cs2)C1.Oc1ccc(-n2cnnn2)cc1>>CC(C)(C)OC(=O)N1CCCC(c2nc(COc3ccc(-n4cnnn4)cc3)cs2)C1,,CC#N,,,,val
US05866568,CCCC[Sn](CCCC)(CCCC)c1ccccn1.COc1nc(C)cnc1N(C(=O)OCC(C)C)S(=O)(=O)c1cccnc1-c1ccc(I)cc1>>COc1nc(C)cnc1N(C(=O)OCC(C)C)S(=O)(=O)c1cccnc1-c1ccc(-c2ccccn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1C,,O,,val
US20140135316A1,CC1(C)CC(=O)Nc2ccccc2N1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC1(C)CC(=S)Nc2ccccc2N1,,C1CCOC1,,,,val
US20040029874A1,CC#N.CC(C)(C)OC(=O)N1CCC(CNc2ccc(N)cc2C(=O)Nc2ccc(Cl)cn2)CC1.CS(=O)(=O)Cl>>CC(C)N1CCC(CNc2ccc(NS(C)(=O)=O)cc2C(=O)Nc2ccc(Cl)cn2)CC1,,CC#N,ClCCl,CCN(C(C)C)C(C)C,,val
US20050203078A1,COC(=O)c1ccc(N2CCCCCS2(=O)=O)c(C)c1>>Cc1cc(C(=O)O)ccc1N1CCCCCS1(=O)=O,,CCO,,O,[Li+].[OH-],val
US20040092510A1,CC(=O)N1N=C(c2ccc([N+](=O)[O-])c(C)c2)c2cc(Cl)c(Cl)cc2CC1C>>CC(=O)N1N=C(c2ccc(N)c(C)c2)c2cc(Cl)c(Cl)cc2CC1C,[Ni],CO,ClCCl,NN,O,val
US20130310334A1,COc1ccc(CNc2ncnc3c2ccn3[C@@H]2O[C@H](CN(CCCNC(=O)Nc3ccc(C(C)(C)C)cc3)C(C)C)[C@H]3OC(C)(C)O[C@H]32)c(OC)c1>>CC(C)N(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)C[C@H]1O[C@@H](n2ccc3c(N)ncnc32)[C@H](O)[C@@H]1O,,O,O=C(O)C(F)(F)F,,,val
US20140329771A1,C=C[C@@H](C)[C@H](O)C[C@@H](C)O[Si](C)(C)C(C)(C)C.CC(C)(C)[Si](C)(C)Cl>>C=C[C@@H](C)[C@@H](C[C@@H](C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C,CN(C)c1ccncc1,CN(C)C=O,,O,c1c[nH]cn1,val
US20050176922A1,O=C1C=CC(=O)N1.c1ccoc1>>O=C1NC(=O)C2C3C=CC(O3)C12,,CCOCC,,,,val
US20100056576A1,C[C@@H]1C[C@@H](c2ccncc2N)C[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C.O=C(O)c1ccc(F)c(Br)n1>>C[C@@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(Br)n2)C[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C,,CCOC(C)=O,,,,val
US05843971,COCCc1sc(C(=O)C(F)(F)F)nc1C.COCCc1scnc1C>>COCCc1sc(C(O)(c2nc(C)c(CCOC)s2)C(F)(F)F)nc1C,,CS(C)=O,,,,val
US20130115190A1,COc1cnc(O[C@@H]2C[C@H]3C(=O)N[C@]4(C(=O)NS(=O)(=O)C5CC5)C[C@H]4C=CCC[C@@H](C)C[C@@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N3C2)c2ccccc12.Cl>>COc1cnc(O[C@@H]2C[C@H]3C(=O)N[C@]4(C(=O)NS(=O)(=O)C5CC5)C[C@H]4C=CCC[C@@H](C)C[C@@H](C)[C@H](N)C(=O)N3C2)c2ccccc12.Cl,,C1COCCO1,,,,val
US20060025459A1,CCn1ncc2c(N(S(=O)(=O)CCCCl)S(=O)(=O)CCCCl)cc(C(=O)OC)cc21>>CCn1ncc2c(N3CCCS3(=O)=O)cc(C(=O)OC)cc21,,CCO,,CCN(CC)CC,,val
US20030008882A1,COc1ccc(-c2ccc(CCC#N)cc2CC(C)C)cc1Cc1ccccc1>>CC(C)Cc1cc(CCC#N)ccc1-c1ccc(O)c(Cc2ccccc2)c1,,ClCCl,,BrB(Br)Br,O,val
US06537730B1,C=CC(Br)c1ccccc1.CP(C)C>>C=CC[P+](C)(C)Cc1ccccc1.[Br-],,CCOCC,,C1CCOC1,,val
US20120277212A1,CC(=O)c1c(O)cccc1O.ClCCCBr>>CC(=O)c1c(O)cccc1OCCCCl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060154929A1,CC(=O)CCC(C)=O.CCOc1ccc(N)cc1>>CCOc1ccc(-n2c(C)ccc2C)cc1,,CC(=O)O,,Cc1ccccc1,,val
US20110172204A1,COC(=O)c1cnc(N2CC(OC)C2)nc1>>COC1CN(c2ncc(C(=O)O)cn2)C1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20080096883A1,Brc1ccc2cnncc2c1.Cc1ccc(NC(=O)c2ccc(CN3CCOCC3)c(C(F)(F)F)c2)cc1Br>>Cc1ccc(NC(=O)c2ccc(CN3CCOCC3)c(C(F)(F)F)c2)cc1-c1ccc2cnncc2c1,,CCOC(C)=O,CO,,,val
US20100143341A1,CCc1cc2c(=O)[nH]cnc2s1.O=P(Cl)(Cl)Cl>>CCc1cc2c(Cl)ncnc2s1,,O=P(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20160046618A1,CC(C)(C)OC(=O)N(COCC[Si](C)(C)C)C1=N[C@](CF)(c2cc(Br)ccc2F)[C@@H]2C[C@]2(CO)S1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC[C@]23C[C@H]2[C@@](CF)(c2cc(Br)ccc2F)N=C(N(COCC[Si](C)(C)C)C(=O)OC(C)(C)C)S3)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20070244186A1,COc1ccc2sc(C)nc2c1[N+](=O)[O-].O=[Se]=O>>COc1ccc2sc(C=O)nc2c1[N+](=O)[O-],,C1COCCO1,,,,val
US20110281838A1,Cc1nc(N)nc(-c2cc(NC(=O)OC(C)(C)C)cc(C(F)(F)F)c2)c1C#Cc1ccc(N)nc1>>Cc1nc(N)nc(-c2cc(N)cc(C(F)(F)F)c2)c1C#Cc1ccc(N)nc1,,C1COCCO1,,Cl,,val
US04489075,C1CO1.CCc1ccncc1>>CC(CCO)c1ccncc1,,O,,CC(C)[N-]C(C)C.[Li+],,val
US05686424,CC[C@H](C)[C@H](N)C(=O)NCc1ccccc1.COc1ccc(C(=O)CBr)cc1.O=C(O)[C@@H]1CCCN1>>CC[C@H](C)[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)c1ccc(OC)cc1,,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US20130289033A1,COc1ccccc1B(O)O.O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1cccc(I)c1>>COc1ccccc1-c1cccc(C(=O)NCCc2c[nH]c3ccc(Cl)cc23)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20060079484A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C=NCc2ccccc2)CC1.O>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C=O)CC1,,C1CCOC1,O,O=C(O)C(=O)O,,val
US20100029657A1,CCN1C2CCC1CC(c1ccnc3c(I)c(-c4ccncc4)nn13)C2.COc1cc(B(O)O)ccn1>>CCN1C2CCC1CC(c1ccnc3c(-c4ccnc(OC)c4)c(-c4ccncc4)nn13)C2,,COCCOC,O,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20130225554A1,CN(C)CC(=O)NNC(=O)[C@H]1CC[C@H]2CN1C(=O)N2OCc1ccccc1>>CN(C)CC(=O)NNC(=O)[C@H]1CC[C@H]2CN1C(=O)N2O,[Pd],CO,,[H][H],,val
US20100305117A1,CCOc1nc(N)nc2ncc(-c3cccc(F)c3F)nc12.N>>Nc1nc(N)c2nc(-c3cccc(F)c3F)cnc2n1,,CO,,,,val
US20140179743A1,O=C1CSC(=O)N1.OCCNC(c1ccccc1)(c1ccccc1)c1ccccc1>>O=C1CSC(=O)N1CCNC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04129656,NCc1ccccc1.O=C1CCc2cc(Cl)c(S(=O)(=O)Cl)cc21>>O=C1CCc2cc(Cl)c(S(=O)(=O)NCc3ccccc3)cc21,,CC(C)=O,,CCN(CC)CC,,val
US20090270454A1,CC(C)(C)OC(=O)N1CCC(Sc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)CC1.Cl>>CC(C)(C)c1cc(SC2CCNCC2)cc(C(C)(C)C)c1O.Cl,,C1COCCO1,,,,val
US20060160864A1,CC(=O)OC(C)=O.O=Cc1cc(Br)ccc1N1CCC(O)C1>>CC(=O)OC1CCN(c2ccc(Br)cc2C=O)C1,,c1ccncc1,,,,val
US20080015208A1,CSC1=NCCN1.NCC1CCCc2cc(NS(=O)(=O)c3ccccc3)ccc21>>O=S(=O)(Nc1ccc2c(c1)CCCC2CNC1=NCCN1)c1ccccc1,,ClCCl,,I,,val
US20080280917A1,O=C1NC(=O)c2ccccc21.O=c1ccc(-c2ccccc2)nn1CCO>>O=C1c2ccccc2C(=O)N1CCn1nc(-c2ccccc2)ccc1=O,,C1CCOC1,CCCCCC,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060217448A1,Nc1ncnc2c1CCN(Cc1ccccc1)C2.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>O=C(Nc1ncnc2c1CCN(Cc1ccccc1)C2)C12CC3CC(CC(C3)C1)C2,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20150045356A1,CCCCCCO.O=C(OCn1c(=O)ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc21)Oc1ccccc1>>CCCCCCOC(=O)OCn1c(=O)ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc21,,C1CCOC1,,O,[H-].[Na+],val
US20100041657A1,CSc1cc(C(C)(C)C)c(O)c(C(=O)Nc2ccc(S(=O)(=O)C(F)(F)F)cc2Cl)c1C.O=C(OO)c1cccc(Cl)c1>>Cc1c(S(C)=O)cc(C(C)(C)C)c(O)c1C(=O)Nc1ccc(S(=O)(=O)C(F)(F)F)cc1Cl,,ClCCl,,,,val
US04263302,CCI.CCOC(=O)c1cnc2c(c1O)C(=O)CCC2>>CCOC(=O)c1cn(CC)c2c(c1=O)C(=O)CCC2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160235716A1,COc1cc(CN(C(=O)CN2C(=O)N[C@]3(CCc4ccccc43)C2=O)[C@@H](C)C2CC2)cnc1NC(=O)OC(C)(C)C>>COc1cc(CN(C(=O)CN2C(=O)N[C@]3(CCc4ccccc43)C2=O)[C@@H](C)C2CC2)cnc1N,,ClCCl,,O=C(O)C(F)(F)F,,val
US04415572,COc1ccc(CCl)cc1.O=C1CCc2c(cccc2N2CCNCC2)N1>>COc1ccc(CN2CCN(c3cccc4c3CCC(=O)N4)CC2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20030100576A1,CC(C)(C)OC(=O)N[C@H]1CC[C@@H](C(=O)O)C1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](CO)C1,,C1CCOC1,,B,,val
US20050250792A1,CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1.O=C(O)Cc1ccc(F)cc1>>O=C(Cc1ccc(F)cc1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20110213109A1,CC1=Cc2cccc([Si](C)(C)Cl)c2C1.Cc1ccc(N)cc1>>CC1=Cc2cccc([Si](C)(C)Nc3ccc(C)cc3)c2C1,,C1CCOC1,,[Li]CCCC,,val
US20040002512A1,COC(=O)[C@@H](N)Cc1ccc(OCc2nc3ccc(OC)cc3n2C)cc1.CS(=O)(=O)OS(C)(=O)=O>>COC(=O)[C@H](Cc1ccc(OCc2nc3ccc(OC)cc3n2C)cc1)NS(C)(=O)=O,,C1CCOC1,CN(C)C=O,c1ccncc1,,val
US20150274691A1,C=CC(C)=O.Fc1ccc(S)cc1>>CC(=O)CCSc1ccc(F)cc1,,C1CCOC1,,O,,val
US20070259863A1,CN(C)CC(=O)Cl.O=C(O)C=Cc1ccc(Sc2cccc(NC3CCNCC3)c2)c(C(F)(F)F)c1C(F)(F)F>>CN(C)CC(=O)N1CCC(Nc2cccc(Sc3ccc(C=CC(=O)O)c(C(F)(F)F)c3C(F)(F)F)c2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150357204A1,CCN(CC)CC.O=C(OCCCCl)c1c2ccccc2cc2ccccc12>>CC[N+](CC)(CC)CCCOC(=O)c1c2ccccc2cc2ccccc12.[Cl-],,CC#N,,,,val
US20060247427A1,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.O=C(O)C(F)(F)F>>CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.O=C([O-])C(F)(F)F,,CC(C)=O,,,,val
US20020143182A1,C1CCOC1.COc1ccc(-c2ccc3cc(CI)ccc3c2)cc1C12CC3CC(CC(C3)C1)C2.O=C1CSC(=O)N1>>COc1ccc(-c2ccc3cc(C4SC(=O)N(C)C4=O)ccc3c2)cc1C12CC3CC(CC(C3)C1)C2,,C1CCOC1,O,[Li]CCCC,,val
US20040048897A1,CN1CCN(S(=O)(=O)c2c(Cl)ccc(N)c2O)CC1.O=c1c(Cl)c(Cl)c1=O>>CN1CCN(S(=O)(=O)c2c(Cl)ccc(Nc3c(Cl)c(=O)c3=O)c2O)CC1,,C1CCOC1,,,,val
US20140378475A1,Cc1c(Br)cccc1NC(=O)c1ccc(F)cc1N.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1c(Br)cccc1-n1c(=O)[nH]c2cc(F)ccc2c1=O,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20040204386A1,Cl.Nc1ccc(Br)cc1I>>Clc1ccc(Br)cc1I,Cl[Cu]Cl,CC#N,,CC(C)(C)ON=O,,val
US20070232645A1,O=Cc1cccc(Oc2ccc(Cl)cc2[N+](=O)[O-])c1>>O=[N+]([O-])c1cc(Cl)ccc1Oc1cccc(CO)c1,,CCO,,[BH4-].[Na+],,val
US20080027124A1,NC(=O)c1[nH]c2ccc(C=O)cc2c1Sc1ccccc1.Nc1ccccc1F>>NC(=O)c1[nH]c2ccc(CNc3ccccc3F)cc2c1Sc1ccccc1,,CO,ClCCl,,,val
US20040048863A1,Cc1ccccc1.N#Cc1cccc(C(=O)O)c1.[N-]=[N+]=[N-]>>COC(=O)c1cccc(-c2nn[nH]n2)c1,,Cc1ccccc1,O,CCN(CC)CC,Cl,val
US20100063066A1,COCn1cc2c(Nc3c(-c4ncccn4)oc4cnccc34)ccc(F)c2n1>>Fc1ccc(Nc2c(-c3ncccn3)oc3cnccc23)c2cn[nH]c12,,Cl,,,,val
US20140142122A1,Cc1cc(C)n2nc(S(C)(=O)=O)nc2n1.OCCN(CCO)c1ccccc1>>Cc1cc(C)n2nc(OCCN(CCO)c3ccccc3)nc2n1,,C1CCOC1,,[H-].[Na+],,val
US09346806B2,C1CCNCC1.CC[C@H](C)Oc1nc(N)c2nc(OC)n(CCCCCCl)c2n1>>CC[C@H](C)Oc1nc(N)c2nc(OC)n(CCCCCN3CCCCC3)c2n1,,ClCCl,,CO,,val
US04830470,CCCCC[C@@H]1CC[C@@H](CCc2ccc(OC)cc2)CC1>>CCCCC[C@@H]1CC[C@@H](CCc2ccc(O)cc2)CC1,,ClCCl,,BrB(Br)Br,,val
US03963725,BrB(Br)Br.COc1cc2c(cc1O)CCNC2COc1ccc(Cl)cc1>>Br.Oc1cc2c(cc1O)C(COc1ccc(Cl)cc1)NCC2,,ClCCl,,,,val
US06765014B1,COc1c(C)ccc2[nH]ccc12>>COc1c(C)ccc2c1CCN2,,CC(=O)O,,O,[BH3-]C#N.[Na+],val
US20100029753A1,COC(=O)c1sccc1N.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1Br>>COC(=O)c1sccc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1Br,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20020045654A1,C=C(C)C=O.N#CC(Nc1ccc(S(N)(=O)=O)cc1)c1ccc(-c2ccco2)cc1>>Cc1cc(-c2ccc(-c3ccco3)cc2)n(-c2ccc(S(N)(=O)=O)cc2)c1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US06372770B1,COc1ccc(-c2nc3cc(Cl)cc(C#CCN(OC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c3o2)cc1OC1CCCC1>>COc1ccc(-c2nc3cc(Cl)cc(C#CCN(O)C(=O)OC(C)(C)C)c3o2)cc1OC1CCCC1,,C1CCOC1,,N,,val
US07855194B2,CCOc1cc(CN2CCC(N)CC2)ccc1OC.COc1cc2nc(Cl)nc(N3CCCCC3)c2cc1OC>>CCOc1cc(CN2CCC(Nc3nc(N4CCCCC4)c4cc(OC)c(OC)cc4n3)CC2)ccc1OC,,OCCO,,,,val
US20150126492A1,COc1cc([N+](=O)[O-])c(C(N)=O)c(F)c1OC>>COc1cc(N)c(C(N)=O)c(F)c1OC,[Fe],CC(=O)O,,,,val
US20140288044A1,C1COCCN1.N#Cc1cc(-c2ccnc(Nc3ccc(Cl)nc3)n2)ccc1OC1CCOCC1.OB(O)/C=C/CCl>>N#Cc1cc(-c2ccnc(Nc3ccc(/C=C/CN4CCOCC4)nc3)n2)ccc1OC1CCOCC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20010047001A1,Cc1cccc(C)c1NC(=O)CN1CCNCC1.c1ccc2c(c1)CC(OCC1CO1)C2>>Cc1cccc(C)c1NC(=O)CN1CCN(CC(O)COC2Cc3ccccc3C2)CC1,,CCO,,,,val
US20120270824A1,CC(=O)OC[C@H]1O[C@H](Oc2ccc(Br)cc2Cl)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.COC(=O)c1ccc(B(O)O)cc1>>COC(=O)c1ccc(-c2ccc(O[C@H]3O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3OC(C)=O)c(Cl)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04097491,BrCC1OCCCO1.CCOC(CN)OCC>>CCOC(CNCC1OCCCO1)OCC,,Cc1ccccc1,,CCN(CC)CC,,val
US20120115918A1,COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc(/C=C(/c3ccc(-c4cnc([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]4)cc3)c3ccc(C(C)(C)C)cc3)cc2)[nH]1)C(C)C>>COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc(C(Cc3ccc(-c4cnc([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]4)cc3)c3ccc(C(C)(C)C)cc3)cc2)c[nH]1)C(C)C,[Pd],CO,,CC(=O)O,,val
US05059597,O=C(O)c1cccnc1C(O)=NCc1ccccc1>>O=C1C2CCCNC2C(=O)N1Cc1ccccc1,[Ru],COCCO,,[H][H],,val
US20130330365A1,CCOC(=O)c1nn(-c2cccc(Cl)c2)c(=O)[nH]1>>O=C(O)c1nn(-c2cccc(Cl)c2)c(=O)[nH]1,,O,,CO,[Li+].[OH-],val
US20030171418A1,C=COCC.C[C@@H](Cn1ncc2ccc(OCC(O)CBr)c(Br)c21)O[Si](C)(C)C(C)(C)C>>CCOC(C)OC(CBr)COc1ccc2cnn(C[C@H](C)O[Si](C)(C)C(C)(C)C)c2c1Br,Cc1ccc(S(=O)(=O)O)cc1,ClCCl,,,,val
US20060004005A1,Nc1ccccc1-c1ccccc1.Nc1nc(Cl)nc(Cl)n1>>Nc1nc(Cl)nc(Nc2ccccc2-c2ccccc2)n1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20070066624A1,CC(C)C[C@@H]1CN(C2CCOCC2)C(=O)N1C1CCNCC1.Cc1nc(Oc2ccc(C(=O)NC3CC3)cc2)ccc1C=O>>Cc1nc(Oc2ccc(C(=O)NC3CC3)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2CC(C)C)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US06090803,Cc1ccn(-c2ccc(C(=O)N3Cc4cccnc4Nc4ccccc43)c(C(F)(F)F)c2)n1.FC(F)(F)c1cc[nH]n1>>O=C(c1ccc(-n2ccc(C(F)(F)F)n2)cc1C(F)(F)F)N1Cc2cccnc2Nc2ccccc21,,CCCCCC,,[H-].[Na+],,val
US04002746,CC[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(OC)ccc4[C@H]3CC[C@@]21C>>CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=C(CC=C(OC)C4)[C@H]3CC[C@@]21C,,CCOCC,,,,val
US20150065703A1,CC(C)(C)[Si](C)(C)Oc1cccc2c1C(O)CC2.O=S(Cl)Cl>>CC(C)(C)[Si](C)(C)Oc1cccc2c1C(Cl)CC2,,Cc1ccccc1,,[K+].[OH-],,val
US20150094439A1,C=C(C)C(=O)Cl.NCc1ccc([N+](=O)[O-])cc1>>C=C(C)C(=O)NCc1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,O,Cl,O=C([O-])O.[Na+],val
US20150336876A1,O=C1c2ccccc2C(=O)N1CCCCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1>>NCCCCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1,,CCO,,NN,O,val
US20010041703A1,CC(C)(C)OC(=O)NC(C)(C)C(=O)O.O=C1CCC(=O)N1O>>CC(C)(C)OC(=O)NC(C)(C)C(=O)ON1C(=O)CCC1=O,,ClCCl,,CCN=C=NCCCN(C)C,,val
US20140303164A1,CC(C)(C)[S@](=O)N[C@@H](Cc1cc(F)cc(F)c1)c1nc(Br)ccc1Br.Cl>>Cl.N[C@@H](Cc1cc(F)cc(F)c1)c1nc(Br)ccc1Br,,C1COCCO1,CO,,,val
US20110144105A1,CS(=O)(=O)c1ccc(B(O)O)cc1.Cc1ccc(S(=O)(=O)OC(=CC2CCCC2)c2cc3cc(C(F)(F)F)cnc3n2S(=O)(=O)c2ccccc2)cc1>>CS(=O)(=O)c1ccc(C(=CC2CCCC2)c2cc3cc(C(F)(F)F)cnc3n2S(=O)(=O)c2ccccc2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20120220577A1,CCOC(=O)C/C(=C\c1cc(Cl)cc(Cl)c1)C(=O)OCC>>O=C(O)c1cc(O)c2c(Cl)cc(Cl)cc2c1,,O=S(=O)(O)O,,,,val
US06235771B1,CCOCCBr.Cc1cc(Br)cc(C)c1O>>CCOCCOc1c(C)cc(Br)cc1C,,CN(C)C=O,O,[H-].[Na+],,val
US20060019994A1,CC(=O)Cl.Cc1ccc(C)c(COC2CCN(S(C)(=O)=O)CC2)c1>>CC(=O)CS(=O)(=O)N1CCC(OCc2cc(C)ccc2C)CC1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US06057311,CC1CCNCC(=O)N(Cc2ccccc2)c2ccccc21.Cc1cccc(N=C=O)c1>>Cc1cccc(NC(=O)N2CCC(C)c3ccccc3N(Cc3ccccc3)C(=O)C2)c1,,C1COCCO1,,,,val
US20090118220A1,CCCCCSc1nc(N)c2nc(O)[nH]c2n1.COC(OC)N(C)C>>CCCCCSc1nc(N=CN(C)C)c2nc(O)[nH]c2n1,,CN(C)C=O,,CC#N,,val
US20110077248A1,O=[N+]([O-])c1cccn2cc(-c3cccc(-c4ccccc4)c3)nc12>>Nc1cccn2cc(-c3cccc(-c4ccccc4)c3)nc12,[Pd],CO,ClCCl,[H][H],,val
US20030096759A1,C1CCOC1.C1COCCN1.COC(=O)c1ccc(C(=O)[O-])cn1>>CC(C)(C)OC(=O)c1ccc(C(=O)N2CCOCC2)nc1,,C1CCOC1,,,,val
US20080139631A1,CCc1nc2c(Cl)c(Br)ccc2[nH]1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CCc1nc2c(Cl)c(Br)ccc2n1CC(F)(F)F,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160264570A1,CI.O=c1[nH]c2cnc3ccc(Br)cc3c2n1-c1cccc(C(F)(F)F)c1>>Cn1c(=O)n(-c2cccc(C(F)(F)F)c2)c2c3cc(Br)ccc3ncc21,,C1CCOC1,,[H-].[Na+],,val
US20120190855A1,COC(=O)c1ccc[n+](C2CC(CO)C(O)C2O)c1.CS(=O)(=O)[O-].N>>CS(=O)(=O)[O-].NC(=O)c1ccc[n+](C2CC(CO)C(O)C2O)c1,,CO,,,,val
US20050054626A1,CC(C)(C)OC(=O)CNc1noc2ccc(C(F)(F)F)cc12>>O=C(O)CNc1noc2ccc(C(F)(F)F)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140213599A1,CS(=O)(=O)Cl.C[C@@H](CO)Nc1cc(Cl)nc(Cl)n1>>C[C@@H](COS(C)(=O)=O)Nc1cc(Cl)nc(Cl)n1,,C1CCOC1,,CCN(CC)CC,,val
US20040082651A1,CC(=O)OC(CC=C(C)CCCC(C)CO)C(C)=O.CC(C)(C)[Si](C)(C)Cl>>CC(=O)OC(CC=C(C)CCC[C@H](C)CO[Si](C)(C)C(C)(C)C)C(C)=O,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,CO,val
US05081246,CN(C(Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)CN1CCC(=O)CC1)S(=O)(=O)c1cccc2cnccc12>>CN(C(Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)CN1CCC(O)CC1)S(=O)(=O)c1cccc2cnccc12,,CO,,[BH4-].[Na+],,val
US20130190289A1,CC(=O)OC1C[C@H](C(=O)O)CC[C@H]1C.O=C(Cl)C(=O)Cl>>CC(=O)OC1C[C@H](C(=O)Cl)CC[C@H]1C,CN(C)C=O,ClCCl,,,,val
US04948893,CCN(CC)c1c(C=O)oc2ccccc12.CCN(CC)c1ccc2cc(C(C)=O)c(=O)oc2c1>>CCN(CC)c1ccc2cc(C=CC(=O)c3c(N(CC)CC)c4ccccc4oc3=O)oc2c1,,CCO,,C1CCNCC1,,val
US20040147543A1,CCOCc1nc2c(N)nc3cc(-c4cccnc4)ccc3c2n1CCCC(Cc1ccc(OC)cc1)S(N)(=O)=O>>CCOCc1nc2c(N)nc3cc(-c4cccnc4)ccc3c2n1CCCCS(N)(=O)=O,,O=C(O)C(F)(F)F,,,,val
US20140235647A1,Clc1ncncc1I.c1c[nH]cn1>>Ic1cncnc1-n1ccnc1,,C1CCOC1,,[H-].[Na+],,val
US20140314669A1,CC(C)(C)OC(=O)N1CCC(CCC(=O)N2CCC[C@@H](C(=O)O)C2)CC1.COC(=O)CC(N)c1cncc(Br)c1>>COC(=O)CC(NC(=O)[C@@H]1CCCN(C(=O)CCC2CCN(C(=O)OC(C)(C)C)CC2)C1)c1cncc(Br)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05750696,CN(C(=O)[C@H](Cc1ccccc1)NC(=O)N1CCCCC1)[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C[C@@H]1OCOC1(C)C.CS(=O)(=O)O>>CN(C(=O)[C@H](Cc1ccccc1)NC(=O)N1CCCCC1)[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C[C@@H]1OCOC1(C)C.CS(=O)(=O)O,,CCO,CCOC(C)=O,,,val
US20140221333A1,CS(=O)(=O)Cl.Nc1nccn2c([C@@H]3CCCNC3)nc(-c3ccc(C(=O)Nc4ccccn4)cc3)c12>>CS(=O)(=O)N1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4ccccn4)cc3)c3c(N)nccn23)C1,,ClCCl,,CCN(CC)CC,,val
US20110190302A1,COCCN(C(=O)OC(C)(C)C)C(CO[Si](C)(C)C(C)(C)C)c1cccc(N)c1.O=S(=O)(Cl)c1ccc(Br)cc1>>COCCN(C(=O)OC(C)(C)C)C(CO[Si](C)(C)C(C)(C)C)c1cccc(NS(=O)(=O)c2ccc(Br)cc2)c1,,CCOC(C)=O,ClC(Cl)Cl,CCN(C(C)C)C(C)C,,val
US20130211075A1,CCOC(=O)C(C#N)=C(C)OCC.NNc1ccc(C(F)(F)F)cn1>>CCOC(=O)c1c(C)nn(-c2ccc(C(F)(F)F)cn2)c1N,,O,,CCO,Cl,val
US20120094972A1,Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21.O=C1CCC(=O)N1Br>>Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC(C)(C)c2nc(Br)c(N3CCOCC3)cc21,,CC#N,,,,val
US20070123527A1,C=C[Mg]Br.COc1ccc(Br)cc1[N+](=O)[O-]>>COc1ccc(Br)c2cc[nH]c12,,C1CCOC1,,,,val
US20030092770A1,CC(C)S(=O)(=O)Cl.CC(O)(CN)c1ccc(I)cc1>>CC(C)S(=O)(=O)NCC(C)(O)c1ccc(I)cc1,,ClCCl,,O,,val
US03989708,CC(=O)C=Cc1cccc(Cl)c1.CCOC(=O)CC(=N)N>>CCOC(=O)C1=C(N)NC(C)=CC1c1cccc(Cl)c1,,CCO,,CC(C)O,,val
US20050176733A1,CNC.Cc1cnc(NC(=O)Nc2cc(Cl)ccc2OCCCN)cn1.O=C(Cl)CCl>>Cc1cnc(NC(=O)Nc2cc(Cl)ccc2OCCCNC(=O)CN(C)C)cn1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120214767A1,CC(=O)O.N#Cc1ccc(C2CCCCC2)c(C(F)(F)F)c1.O>>O=C(O)c1ccc(C2CCCCC2)c(C(F)(F)F)c1,,O,,Cl,,val
US20130096113A1,CSc1nc2ccc(Cn3cnc4cc(C(F)(F)F)cnc43)cc2s1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc2ccc(Cn3cnc4cc(C(F)(F)F)cnc43)cc2s1,,ClCCl,,,,val
US20030109459A1,COC(=O)[C@H](Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1)NC(=O)OC(C)(C)C.Cl>>COC(=O)[C@@H](N)Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1.Cl,,C1COCCO1,,CCOCC,,val
US20090054440A1,Brc1nccs1.NNc1ccccc1>>NN(c1ccccc1)c1nccs1,,C1COCCO1,,[H-].[Na+],,val
US20120142671A1,NC(CC(F)(F)F)C(=O)O.O=C(Cl)OCc1ccccc1>>O=C(NC(CC(F)(F)F)C(=O)O)OCc1ccccc1,,C1COCCO1,,[Na+].[OH-],,val
US20150266857A1,CC(C)(C)OC(=O)n1cc(B2OC(C)(C)C(C)(C)O2)c2ccc(F)cc21.O=C1NS(=O)(=O)c2ccc(Br)cc21>>CC(C)(C)OC(=O)n1cc(-c2ccc3c(c2)C(=O)NS3(=O)=O)c2ccc(F)cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US05068392,CC(=O)Nc1c(Cl)cc(Br)c(C)c1Cl>>Cc1c(Br)cc(Cl)c(N)c1Cl,,O,,CCO,[Na+].[OH-],val
US20030187014A1,CCCCO.Cc1nn(-c2ccccn2)c2nc3ccccc3c(Cl)c12>>CCCCOc1c2ccccc2nc2c1c(C)nn2-c1ccccn1,,C1CCOC1,,[H-].[Na+],,val
US03964896,O=C(O)c1ccccc1-c1nnc(-c2cccnc2)o1>>Cc1ccccc1-c1nnc(-c2cccnc2)o1,,CCO,,,,val
US03969402,CC(=O)c1ccc(Br)c([N+](=O)[O-])c1.Fc1ccc(I)cc1>>CC(=O)c1ccc(-c2ccc(F)cc2)c([N+](=O)[O-])c1,,CO,,,,val
US20010021714A1,CC(=O)OCCc1ccc2c(c1)OCO2.O=[N+]([O-])O>>CC(=O)OCCc1cc2c(cc1[N+](=O)[O-])OCO2,,CC(=O)O,,O,,val
US06376503B1,CC(C)(C)OC(=O)NCCN.N#Cc1ccc(N2CCC(=O)CC2)cc1>>CC(C)(C)OC(=O)NCCNC1CCN(c2ccc(C#N)cc2)CC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20090105302A1,C=CC1CC1(NC(=O)C1CC(O)CN1)C(=O)OCC.CC(C)(C)[Si](C)(C)Cl>>C=CC1CC1(NC(=O)C1CC(O[Si](C)(C)C(C)(C)C)CN1)C(=O)OCC,,ClCCl,,c1c[nH]cn1,,val
US20140206701A1,NC(Cc1ccncc1)c1cccc(Cl)c1Cl.S=C=NCCCl>>Clc1cccc(C(Cc2ccncc2)N=C2NCCS2)c1Cl,,ClCCl,,,,val
US05273986,NC(=S)/C=C/c1cccc([N+](=O)[O-])c1.O=C(CBr)C1CCCCCC1>>O=[N+]([O-])c1cccc(/C=C/c2nc(C3CCCCCC3)cs2)c1,,CCO,,,,val
US05885986,CCCN(CCC)Cc1cnc(-c2ncn3c2[C@@H]2CCN2C(=O)c2c(Cl)cccc2-3)o1.Cl>>CCCN(CCC)Cc1cnc(-c2ncn3c2[C@@H]2CCN2C(=O)c2c(Cl)cccc2-3)o1.Cl,,CCO,,CCOCC,,val
US20140249129A1,N#Cc1ccc(C=O)c(F)c1.NC(=O)Nc1cccc(C(F)(F)F)c1.O=C1CCCC(=O)C1>>N#Cc1ccc(C(NC(=O)Nc2cccc(C(F)(F)F)c2)C2=C(O)CCCC2=O)c(F)c1,,CC#N,CN(C)C=O,C[Si](C)(C)Cl,,val
US20010039268A1,CN(C)CCOc1ccc([C@H]2C[C@]3(C)C(=O)CC[C@H]3[C@@H]3CCC4=CC(=O)CCC4=C23)cc1.O=S(=O)(Cl)Cl>>CN(C)CCOc1ccc([C@H]2C[C@]3(C)C(=O)CC[C@H]3[C@@H]3CCC4=C(Cl)C(=O)CCC4=C23)cc1,,ClCCl,c1ccncc1,O=C([O-])O.[Na+],,val
US20090247523A1,COC(=O)C1CC(NC(=O)c2cnccc2Nc2nc(-c3cc(Cl)ccc3F)ncc2OC)CN1C(=O)OC(C)(C)C>>COC(=O)C1CC(NC(=O)c2cnccc2Nc2nc(-c3cc(Cl)ccc3F)ncc2OC)CN1,,C1COCCO1,,,,val
US20070049618A1,NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1ccc(C(F)(F)F)c(F)c1>>O=C1CCC(N2C(=O)c3cccc(CNC(=O)c4ccc(C(F)(F)F)c(F)c4)c3C2=O)C(=O)N1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20140228372A1,CC(C)(C)OC(=O)N1CCC(c2csc(NC(=O)Cc3c(F)cccc3Cl)n2)CC1.Cl>>Cl.O=C(Cc1c(F)cccc1Cl)Nc1nc(C2CCNCC2)cs1,,CCO,,CO,ClCCl,val
US20160090374A1,CC(C)(C)OC(=O)N[C@@H]1CCCN(c2nc(Cl)nc3c2CCC3)C1.CI>>CN(C(=O)OC(C)(C)C)[C@@H]1CCCN(c2nc(Cl)nc3c2CCC3)C1,,O,,CN(C)C=O,[H-].[Na+],val
US20070219198A1,CC(=O)c1cccc(S(=O)(=O)Cl)c1.C[C@@H]1CN(c2ccc(C#N)nc2)CCN1>>CC(=O)c1cccc(S(=O)(=O)N2CCN(c3ccc(C#N)nc3)C[C@H]2C)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05994378,CC(C)(C)c1ccc2[nH]c(C(=O)O)cc2c1>>CC(C)(C)c1ccc2[nH]ccc2c1,,c1ccc2ncccc2c1,,,,val
US03993679,CCOC(=O)C(=O)Nc1cc(NC(=O)C(=O)OCC)cc(C(N)=O)c1.O>>NC(=O)c1cc(NC(=O)C(=O)O)cc(NC(=O)C(=O)O)c1.O,,ClCCl,,[Na+].[OH-],,val
US09180192B2,O=C(Cl)c1ccccn1.O=[N+]([O-])c1cn[nH]c1>>O=C(Nc1cn[nH]c1)c1ccccn1,[Pd],CCO,,CCN(CC)CC,Cl,val
US20100113464A1,CC1(O)OC(=O)C(c2c(F)cc(F)cc2F)=C1c1cccs1.NN>>Cc1n[nH]c(=O)c(-c2c(F)cc(F)cc2F)c1-c1cccs1,,CCCCO,,O,,val
US04785019,ClSC(Cl)(Cl)C(Cl)Cl.N#CCNC(=O)c1cccc2ccccc12>>N#CCN(SC(Cl)(Cl)C(Cl)Cl)C(=O)c1cccc2ccccc12,,ClCCl,,CCN(CC)CC,,val
US20080146614A1,CCCS(=O)(=O)Cl.O=C(NC1CCC(F)(F)CC1)c1nn(-c2ccc(Cl)cc2Cl)c(-c2ccc(O)cc2)c1CO>>CCCS(=O)(=O)Oc1ccc(-c2c(CO)c(C(=O)NC3CCC(F)(F)CC3)nn2-c2ccc(Cl)cc2Cl)cc1,,ClCCl,,CCN(CC)CC,O,val
US04134898,CCOC(=O)CC1=C(O)c2sccc2S(=O)(=O)N1.CI>>CCOC(=O)CC1=C(O)c2sccc2S(=O)(=O)N1C,,CN(C)C=O,,[H-].[Na+],,val
US20120122853A1,CCOC(=O)/C=C/c1nc(-c2ccc(C(F)(F)F)cc2)ccc1N>>CCOC(=O)CCc1nc(-c2ccc(C(F)(F)F)cc2)ccc1N,[Pd],C1CCOC1,,,,val
US07763614B2,CC(C)OCC1CO1.COc1ccc2c(=O)[nH]c(C#N)c(-c3ccccc3)c2c1>>COc1ccc2c(=O)n(CC(O)COC(C)C)c(C#N)c(-c3ccccc3)c2c1,,CC(C)O,,c1ccncc1,,val
US20080125452A1,CN=C=S.COC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cc(OC)cc(OC)c2)N1>>COc1cc(OC)cc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(C)C(=S)N32)c1,,CC(C)=O,,,,val
US05208247,O=C(Cl)C(=O)Cl.O=C(O)c1ccccn1>>Cl.O=C(Cl)c1ccccn1,CN(C)C=O,ClCCl,,,,val
US20060079533A1,CC(C)(C)OC(=O)N1CCC(c2ccc(CC(=O)NCC(=O)c3ccccc3)cc2)C(OCc2ccc3ccccc3c2)C1.O=C(O)C(F)(F)F>>O=C(Cc1ccc(C2CCNCC2OCc2ccc3ccccc3c2)cc1)NCC(=O)c1ccccc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20030100764A1,O=S(Cl)Cl.O=[N+]([O-])c1cnc2ccccc2c1NCCCCCCO>>O=[N+]([O-])c1cnc2ccccc2c1NCCCCCCCl,,ClCCl,,,,val
US20030069434A1,CN.Cc1ccc(S(=O)(=O)[O-])c(CCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c1>>CNCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,,C1CCOC1,,,,val
US20100168351A1,Nc1ccc(I)cc1.O=Cc1cccc(-c2ccccc2)c1O>>Oc1c(C=Nc2ccc(I)cc2)cccc1-c1ccccc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20050187387A1,CC(c1ccc2ncccc2c1)N1CCC(NC(=O)OC(C)(C)C)CC1>>CC(c1ccc2ncccc2c1)N1CCC(N)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04988698,CCOC(=O)c1cn2ccc(CC)cc2n1>>CCc1ccn2cc(C(=O)O)nc2c1,,CCO,O,Cl,[Na+].[OH-],val
US20120035214A1,CCO.Nc1c(NC=O)cccc1C(=O)O>>CCOC(=O)c1cccc2[nH]cnc12,,CCO,,CC(=O)Cl,,val
US20100305131A1,CC(C)(C)OC(=O)CBr.O=C(CCc1ccc(-c2ccccc2)cc1)N1C(=O)OC[C@@H]1Cc1ccccc1>>CC(C)(C)OC(=O)C[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1,,C1CCOC1,,,,val
US20140162971A1,C[Mg]Br.Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2cc(C=O)[nH]c2c1=O>>CC(O)c1cc2c(-c3cc(S(C)(=O)=O)ccc3Oc3ccc(F)cc3F)cn(C)c(=O)c2[nH]1,,C1CCOC1,,Cl,,val
US05952362,CCOC(=N)COc1cccc(NS(C)(=O)=O)c1.Cl.NCCN>>CS(=O)(=O)Nc1cccc(OCC2=NCCN2)c1.Cl,,CO,,,,val
US20070129341A1,CCOC(=O)C(Cc1ccc(N)nc1)c1cn(CCC2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)cn1>>Nc1ccc(CC(C(=O)O)c2cn(CCC3CCN(C(=O)C(c4ccccc4)c4ccccc4)CC3)cn2)cn1,,CCO,,Cl,[Na+].[OH-],val
US20140057899A1,C[Si](C)(C)CCOCn1cc(I)c2c(Cl)ncnc21.N>>C[Si](C)(C)CCOCn1cc(I)c2c(N)ncnc21,,CO,O,,,val
US05270289,C=CCBr.COC(=O)CSc1nc(OC)cc(OC)n1>>C=CCC(Sc1nc(OC)cc(OC)n1)C(=O)OC,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US20160145247A1,CC(C)(C)OC(=O)NCc1cccc(-c2cccc(C=O)n2)c1>>CC(C)(C)OC(=O)NCc1cccc(-c2cccc(CO)n2)c1,,CO,,[BH4-].[Na+],,val
US05536846,CCCCN.O=C1OC(=O)c2ccccc21>>CCCCN1C(=O)c2ccccc2C1=O,,O,,,,val
US20050049245A1,CNCC(O)c1cc(C)oc1C.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)sc21>>Cc1cc(C(O)CN(C)Cc2cc3c(=O)c(C(=O)NCc4ccc(Cl)cc4)cn(C)c3s2)c(C)o1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US04358440,COC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1)[C@@H](C)O.NN>>C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NN,,CO,,O,,val
US05002935,CI.COc1ccc2c(C(C)C(=O)OCCNC(=O)c3cccnc3)cccc2c1>>COc1ccc2c(C(C)C(=O)OCCNC(=O)c3ccc[n+](C)c3)cccc2c1.[I-],,CC(C)=O,,,,val
US05424333,CC(C)(C)N(N)C(=O)c1ccccc1.Cc1ccc(N=C=O)cc1>>Cc1ccc(NC(=O)NN(C(=O)c2ccccc2)C(C)(C)C)cc1,,CCOCC,CCOCC,,,val
US20110190297A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.O=C(OCc1ccccc1)N1CCNCC1>>CC(C)(C)OC(=O)N1CCC(C(=O)N2CCN(C(=O)OCc3ccccc3)CC2)CC1,,CN(C)C=O,ClC(Cl)Cl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06121307,BrC(Br)(Br)Br.OCCCc1c[nH]c2ccc(F)cc12>>CCC(Br)c1cc2cc(F)ccc2[nH]1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070203192A1,CN(C)CC1Cc2cc(OC(F)(F)F)ccc2C1(O)c1cccnc1.Cl>>CN(C)CC1=C(c2cccnc2)c2ccc(OC(F)(F)F)cc2C1.Cl,,CC(C)=O,,Cl,,val
US06696456B1,CCS[C@H](c1ccccc1)[C@@H](NS(=O)(=O)c1ccc(-c2ccc(F)cc2)cc1)C(=O)OC>>CCS[C@H](c1ccccc1)[C@@H](NS(=O)(=O)c1ccc(-c2ccc(F)cc2)cc1)C(=O)O,,c1ccncc1,,[I-].[Li+],,val
US20140296208A1,COc1c(N)cc(C(C)(C)C)cc1[N+](=O)[O-].O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1c(NS(=O)(=O)C(F)(F)F)cc(C(C)(C)C)cc1[N+](=O)[O-],,ClC(Cl)Cl,,CCN(CC)CC,,val
US20040006112A1,O=C(O)CN1C(=O)CSC1=S.O=Cc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1>>O=C(O)CN1C(=O)C(=Cc2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)SC1=S,,CC(=O)O,O,CC(=O)[O-].[Na+],,val
US20040009968A1,CC(C)(C)OC(=O)OC(=O)[O-].Nc1n[nH]c2ccc([N+](=O)[O-])cc12>>CC(C)(C)OC(=O)n1nc(N)c2cc([N+](=O)[O-])ccc21,,C1CCOC1,,CCN(CC)CC,CN(C)c1ccccn1,val
US05167863,CCCCO[C@H](C)[C@@H](C)O.CS(=O)(=O)Cl>>CCCCO[C@H](C)[C@@H](C)OS(C)(=O)=O,,ClCCl,,CCN(CC)CC,O,val
US20070213336A1,CCCCOc1cc(C(=O)OC)ccc1I>>CCCCOc1cc(CO)ccc1I,,C1CCOC1,,Cl,[BH4-].[Li+],val
US20160031838A1,C=CC(=O)N(CCN(CCc1ccc(O)c2c1OCC(=O)N2)C(=O)OC(C)(C)C)C1CCCCC1.CO>>COCCC(=O)N(CCNCCc1ccc(O)c2c1OCC(=O)N2)C1CCCCC1,,CO,ClCCl,,,val
US04112095,CC(=O)NN.FC(F)(F)c1ccc(-c2ccc(Cl)nn2)cc1>>Cc1nnc2ccc(-c3ccc(C(F)(F)F)cc3)nn12,,CCCCO,,,,val
US20030186984A1,CN[C@@H]1CC[C@@H](C#CCO)CC1.Clc1ccc(Cl)nn1>>CN(c1ccc(Cl)nn1)[C@@H]1CC[C@@H](C#CCO)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20110257151A1,COC(=O)c1ccc2c(c1)CC(C)(C)C(c1ccc(NC(=O)C3CCCCC3)cc1)N2>>CC1(C)Cc2cc(C(=O)O)ccc2NC1c1ccc(NC(=O)C2CCCCC2)cc1,,CO,O,[Na+].[OH-],,val
US20020156277A1,CCCCC(OC)(OC)OC.CCOC(=O)c1ccc(NC(=O)C(C)n2cnc(C(N)=O)c2N)cc1>>CCCCc1nc2c(ncn2C(C)C(=O)Nc2ccc(C(=O)OCC)cc2)c(=O)[nH]1,,CN(C)C=O,,,,val
US20140148433A1,CCOC(C)=O.CI.Nc1nc(-n2nc(Cc3ccccc3F)c3ncccc32)nc(N)c1N>>Cn1c(=O)[nH]c2nc(-n3nc(Cc4ccccc4F)c4ncccc43)nc(N)c21,,CCOC(C)=O,,C1CCOC1,,val
US20110306587A1,C1CCNCC1.Cn1c(C(=O)N2CC(c3nccnc3Cl)C2)nc2ccccc21>>Cn1c(C(=O)N2CC(c3nccnc3N3CCCCC3)C2)nc2ccccc21,,O,,CCN(CC)CC,CS(C)=O,val
US20100311748A1,Cc1ccc(C#N)cc1N.O=C(Cl)c1ccc(OCc2ccccn2)cc1>>Cc1ccc(C#N)cc1NC(=O)c1ccc(OCc2ccccn2)cc1,,c1ccncc1,,Cl,,val
US20060247260A1,Brc1ccc(OCc2ccccc2)cc1.CCCC[Sn](CCCC)(CCCC)c1ccc(C(=O)OC)s1>>COC(=O)c1ccc(-c2ccc(OCc3ccccc3)cc2)s1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US20090124612A1,COc1ccc2c(OCc3nnc4ccc(C#N)cn34)ccnc2c1.O=S(=O)(O)O>>COc1ccc2c(OCc3nnc4ccc(C(N)=O)cn34)ccnc2c1,,O=S(=O)(O)O,,O=C([O-])O.[Na+],,val
US20130210795A1,C[C@H](Cl)CO.O=Cc1ccc(O)cc1>>C[C@H](CO)Oc1ccc(C=O)cc1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20050197330A1,CC(=O)c1c2c(nn1C)N(c1c(C)cc(C)cc1C)CCC2.CON>>CON=C(C)c1c2c(nn1C)N(c1c(C)cc(C)cc1C)CCC2,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20010051620A1,N#Cc1cnc2c(sc3ccc([N+](=O)[O-])cc32)c1Cl.Nc1ccc(Cl)cc1Cl>>N#Cc1cnc2c(sc3ccc([N+](=O)[O-])cc32)c1Nc1ccc(Cl)cc1Cl,,CN(C)C=O,,[H-].[Na+],,val
US20160137704A1,CC12COC(CCCC#C[C@H]3OC(=O)N4[C@H]3CSC4(C)C)(OC1)OC2.O=C(O)C(F)(F)F>>CC(CO)(CO)COC(=O)CCCC=C1SC[C@@H]2NC(=O)O[C@H]12,,O,,ClCCl,O=C([O-])O.[Na+],val
US20040167171A1,Cc1c(C)c(N2CCN(Cc3ccccc3)CC2)c(C)c2c1OC(C)(C)C2(O)c1ccc(F)nc1>>Cc1c(C)c(N2CCN(Cc3ccccc3)CC2)c(C)c2c1OC(C)(C)C2c1ccc(F)nc1,,CCCCCC,,,,val
US20110288084A1,O=C(N[C@@H]1CC[C@@H](C(O)CNS(=O)(=O)c2ccccc2[N+](=O)[O-])CC1)C(F)(F)F>>N[C@@H]1CC[C@@H](C(O)CNS(=O)(=O)c2ccccc2[N+](=O)[O-])CC1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20030008841A1,Cl.O=c1ccn2c(n1)OC1C(O)C(CO)OC12>>O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2Cl)c(=O)[nH]1,,ClC(Cl)Cl,,,,val
US20060257987A1,CCOC(=O)CSc1ccc(OCC[C@H](C)OS(C)(=O)=O)cc1C.CCc1ccc(O)c(Oc2ccccc2)c1>>CCOC(=O)CSc1ccc(OCCC(C)Oc2ccc(CC)cc2Oc2ccccc2)cc1C,,CN(C)C=O,O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20040204417A1,CC(C)CC(=O)Cl.CCOC(=O)c1cc2cc(NCc3cncn3Cc3ccc(C#N)cc3)ccc2s1>>CCOC(=O)c1cc2cc(N(Cc3cncn3Cc3ccc(C#N)cc3)C(=O)CC(C)C)ccc2s1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20130338140A1,COC(=O)C[C@H](CN(C)C(=O)OC(C)(C)C)c1ccc(Cl)c(F)c1>>CN(C[C@@H](CC(=O)O)c1ccc(Cl)c(F)c1)C(=O)OC(C)(C)C,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20100204196A1,COc1cc2c(cc1[N+](=O)[O-])N(C(=O)[C@@H]1CCCN1C)CC2>>COc1cc2c(cc1N)N(C(=O)[C@@H]1CCCN1C)CC2,[Pd],CO,,C1CCOC1,,val
US20140275030A1,Cc1noc(C)c1-c1ccc2nc(N3CCCNCC3)n3c2c1OC[C@@H]3c1ccccn1.NS(N)(=O)=O>>Cc1noc(C)c1-c1ccc2nc(N3CCCN(S(N)(=O)=O)CC3)n3c2c1OC[C@@H]3c1ccccn1,,CO,c1ccncc1,,,val
US20100004451A1,c1cnc2cc3c(cc2n1)C1CNCC3C1>>c1cnc2cc3c(cc2n1)C1CNCC3C1,,O,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20120282218A1,CCCC[Sn](C=COCC)(CCCC)CCCC.O=c1c(I)cc(Cc2ccc(F)cc2F)cn1Cc1ccccc1F>>CC(=O)c1cc(Cc2ccc(F)cc2F)cn(Cc2ccccc2F)c1=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US20040157886A1,Nc1ccc(Br)cc1.O=C(O)C(=O)N1CCC(Cc2ccc(F)cc2)CC1>>O=C(Nc1ccc(Br)cc1)C(=O)N1CCC(Cc2ccc(F)cc2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100130474A1,COc1ccc(-c2n[nH]c(N)c2F)cn1.O=C(O)CCCN1CCCCC1.O=C(n1ccnc1)n1ccnc1>>COc1ccc(-c2n[nH]c(NC(=O)CCCN3CCCCC3)c2F)cn1.O=CO,,ClCCCl,,Cl,,val
US20160000760A1,CI.C[C@H](NS(C)(=O)=O)c1ccc(-c2c(Cl)cc(N=C=S)cc2C(F)(F)F)cc1.N#CN>>CSCN(NC#N)c1cc(Cl)c(-c2ccc([C@H](C)NS(C)(=O)=O)cc2)c(C(F)(F)F)c1,,CO,,[Na],,val
US20120277423A1,C=CCC(O)c1cccc2ccccc12>>C=CCC(=O)c1cccc2ccccc12,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20070225324A1,CNC(=O)[C@@H](C(C)C)n1ccc2c([N+](=O)[O-])cccc2c1=O>>CNC(=O)[C@@H](C(C)C)n1ccc2c(N)cccc2c1=O,[Pd],,,CO,,val
US20010027196A1,COCCO.N#Cc1c(Cl)nc(N)nc1-c1ccccc1>>COCCOc1nc(N)nc(-c2ccccc2)c1C#N,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20090099155A1,C=C(C)n1c(=O)n(CCCBr)c2ccccc21.CN(C)C(=O)Sc1c(Cl)ccc2c1CCN(C(=O)OC(C)(C)C)CC2>>CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(SCCCn3c(=O)[nH]c4ccccc43)c2CC1,,CO,,[K+].[OH-],,val
US20030232808A1,CN(C)C=O.ClCCl.O=C(O)c1ccc(Cl)nc1>>CON(C)C(=O)c1ccc(Cl)nc1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20140227444A1,CC(C)(C)N=CC(=O)C(C)(C)C.[Li]C>>CC(C)(C)N=CC(C)(O)C(C)(C)C,,CCOCC,,,,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(Oc3cnccn3)cc(OC)c21>>COc1cc(Oc2cnccn2)cc2c1C(CC(=O)O)OB2O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US04820727,COC(=O)Cl.COc1ccc2c(C(N)=O)c(Br)ccc2c1C(F)(F)F>>COC(=O)NC(=O)c1c(Br)ccc2c(C(F)(F)F)c(OC)ccc12,,C1CCOC1,O,[H-].[Na+],[Cl-].[NH4+],val
US03962240,CC1(C)OC(C)(C)C(=O)C1=O.N=C(NN)c1cccc([N+](=O)[O-])c1>>CC1(C)OC(C)(C)c2nc(-c3cccc([N+](=O)[O-])c3)nnc21,,CCO,,,,val
US20100135999A1,CCOC(=O)c1cc(O)c2ccc(C)cc2n1>>Cc1ccc2c(O)cc(C(=O)O)nc2c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US04696949,BrC(Br)(Br)Br.COc1ccc(/C(=C(/CCO)c2ccccc2)c2ccccc2)cc1>>COc1ccc(C(=C(CCBr)c2ccccc2)c2ccccc2)cc1,,CC#N,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US03992535,COC(=O)C1=C(O)c2ccc3ccccc3c2S(=O)(=O)N1C.Cc1cccc(N)c1>>Cc1cccc(NC(=O)C2=C(O)c3ccc4ccccc4c3S(=O)(=O)N2C)c1,,Cc1ccccc1C,,,,val
US20120101083A1,Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(=O)CNC(=O)OC(C)(C)C)CC2.Cl>>Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(=O)CN)CC2.Cl,,C1COCCO1,,,,val
US20110201656A1,COc1ccc(CC(C)=O)cc1.[N-]=[N+]=Nc1ccc(C(F)(F)F)cc1F>>COc1ccc(-c2nnn(-c3ccc(C(F)(F)F)cc3F)c2C)cc1,,CO,,C[O-].[Na+],,val
US20040147748A1,CS(=O)(=O)Nc1ccc([N+](=O)[O-])nc1>>CS(=O)(=O)Nc1ccc(N)nc1,[Zn],CO,O,[Cl-].[NH4+],,val
US20080027116A1,C1CCOC1.CC(C)(C)OC(=O)N[C@@H](Cc1cscn1)C(=O)O.CCN(CC)CC>>C[C@@H]1CCCN1C(=O)[C@H](Cc1cscn1)NC(=O)OC(C)(C)C,,C1CCOC1,,On1nnc2ccccc21,,val
US20130289020A1,CC(C)(C)OC(=O)c1cccc(Cl)n1.OC1CCN(Cc2ccccc2)CC1>>O=C(O)c1cccc(OC2CCN(Cc3ccccc3)CC2)n1,,C1COCCO1,,[H-].[Na+],,val
US05021576,COC(=O)Cc1cc(OCCCCOc2ccccc2)ccc1Nc1c(Cl)cccc1Cl>>O=C(O)Cc1cc(OCCCCOc2ccccc2)ccc1Nc1c(Cl)cccc1Cl,,C1CCOC1,,[Li+].[OH-],,val
US20080275018A1,CC(C)(C)OC(=O)NCCC[C@@H](CC(=O)NCCNC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1.Cl>>Cl.NCCC[C@@H](CC(=O)NCCNC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1,,C1COCCO1,,,,val
US04242519,CI.COC(=O)C(SC)c1ccc2cc(OC)ccc2c1>>COC(=O)C(C)(SC)c1ccc2cc(OC)ccc2c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20160113928A1,CNC1CCN(c2nnc(-c3ccnn3C)c3ccccc23)CC1.N#Cc1ccccc1CBr>>CN(Cc1ccccc1C#N)C1CCN(c2nnc(-c3ccnn3C)c3ccccc23)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20140073623A1,Cc1ccc(S(=O)(=O)Oc2c(Br)ccc(N)c2C(=O)OC(C)(C)C)cc1.O=C(Cl)OCc1ccccc1>>Cc1ccc(S(=O)(=O)Oc2c(Br)ccc(NC(=O)OCc3ccccc3)c2C(=O)OC(C)(C)C)cc1,,c1ccncc1,,,,val
US20120214762A1,CC(=O)c1cc(CO)on1.CI>>COCc1cc(C(C)=O)no1,,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090062328A1,CCOC(=O)CCC1(C)OCCO1>>CC1(CCC(=O)O)OCCO1,,CO,O,[Na+].[OH-],,val
US20090143385A1,Cc1ccc(Cl)nn1.Cc1onc(-c2ccccc2)c1CO>>Cc1ccc(OCc2c(-c3ccccc3)noc2C)nn1,,C1CCOC1,,O,[H-].[Na+],val
US20100029637A1,COC(=O)CCCSc1nc2ccccn2c1Cc1csc2cccc(C)c12>>Cc1cccc2scc(Cc3c(SCCCC(=O)O)nc4ccccn34)c12,,C1CCOC1,O,[Li+].[OH-],,val
US20080004271A1,COc1cc(-c2nc(SC)nc(Cl)c2C#N)cc(Cl)c1Cl.NC(=O)CS>>COc1cc(-c2nc(SC)nc(SCC(N)=O)c2C#N)cc(Cl)c1Cl,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20030119819A1,CCOC(=O)CN1CCN(CCCc2c(C=O)[nH]c3c2CCCC3)CC1>>O=Cc1[nH]c2c(c1CCCN1CCN(CC(=O)O)CC1)CCCC2,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20120149675A1,COC(=O)c1ccc(Cl)nc1.Cc1nnn(-c2ccccc2F)c1-c1c[nH]cn1>>COC(=O)c1ccc(-n2cnc(-c3c(C)nnn3-c3ccccc3F)c2)nc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US03931201,CN(C(N)=O)c1ccc(Oc2cccc(Cl)n2)cc1.ClSc1ccc(Cl)cc1>>CN(Sc1ccc(Cl)cc1)C(=O)Nc1ccc(Oc2cccc(Cl)n2)cc1,,CCCCCC,,O,c1ccncc1,val
US20100331293A1,CCOC(=O)C(C)C(=O)Nc1cc(F)cc(F)c1Cl>>CC(C(=O)O)C(=O)Nc1cc(F)cc(F)c1Cl,,C1CCOC1,,,,val
US20100204472A1,CCC(=O)CBr.CCOC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(C(N)=S)cc3OC)ccc21>>CCOC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(-c4nc(CC)cs4)cc3OC)ccc21,,CCO,,,,val
US20080096874A1,CC(=O)N1CCN(c2ccc(NC(=O)C(=O)NN)cc2)CC1.CCOc1cccc(NC(=S)Oc2c(F)c(F)c(F)c(F)c2F)c1>>CCOc1cccc(Nc2nnc(C(=O)Nc3ccc(N4CCN(C(C)=O)CC4)cc3)o2)c1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US05262390,COC(=O)COc1cc(C)ccc1CO.O=S(Cl)Cl>>COC(=O)COc1cc(C)ccc1CCl,c1ccncc1,ClCCl,,,,val
US20160031875A1,CC(C)(C)CC(=O)Nc1nc2ccc(C(O)CO)nc2n1CC(F)(F)F>>CC(C)(C)CC(=O)Nc1nc2ccc(C=O)nc2n1CC(F)(F)F,,ClCCl,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US06465687B1,COC(=O)c1cc(Br)c(Oc2ccc(OC)c(C(C)C)c2)c(Br)c1>>COc1ccc(Oc2c(Br)cc(CO)cc2Br)cc1C(C)C,,C1CCOC1,,,,val
US20050148621A1,CN(CCCN)CCCNc1c2c(nc3cc(Cl)ccc13)CCCC2.O=C(O)CCc1c[nH]c2ccccc12>>CN(CCCNC(=O)CCc1c[nH]c2ccccc12)CCCNc1c2c(nc3cc(Cl)ccc13)CCCC2,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20070037809A1,CN(C)c1cccc(C(=O)Nc2cccc(-c3nc4nc(CN5CCN(C(=O)OC(C)(C)C)CC5)ccc4o3)c2)c1>>CN(C)c1cccc(C(=O)Nc2cccc(-c3nc4nc(CN5CCNCC5)ccc4o3)c2)c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080125468A1,CNOC.COC(=O)c1ccc(Br)c(C)c1>>CON(C)C(=O)c1ccc(Br)c(C)c1,,C1CCOC1,,CC(C)[Mg]Cl,Cl,val
US20120214762A1,CN(C)C(=O)c1n[nH]c2cc(Br)ccc12.Nc1nccc(Cl)n1>>CN(C)C(=O)c1nn(-c2ccnc(N)n2)c2cc(Br)ccc12,,CN(C)C=O,,[H-].[Na+],,val
US20110251173A1,CN.O=Cc1ccc(Br)c(Cl)c1>>C/N=C\c1ccc(Br)c(Cl)c1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130090480A1,CCc1ccc(Nc2nc3cc([N+](=O)[O-])ccc3o2)cc1>>CCc1ccc(Nc2nc3cc(N)ccc3o2)cc1,[Pd],CO,,[H][H],,val
US20140221330A1,CC(C)(C)[Si](C)(C)OC1CCC(C(C(=O)O)C(O)(C(=O)O)C2CCCC2)CC1>>CC(C)(C)[Si](C)(C)O[C@H]1CC[C@@H](C2=C(C3CCCC3)C(=O)OC2=O)CC1,,CC(=O)OC(C)=O,,,,val
US20050080082A1,CCOC(=O)c1ccc(Sc2c(-c3cc(Cl)ccc3OC)c3cc(C(F)(F)F)ccc3[nH]c2=O)cc1>>COc1ccc(Cl)cc1-c1c(Sc2ccc(C(=O)O)cc2)c(=O)[nH]c2ccc(C(F)(F)F)cc12,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20110178107A1,CC(C)Oc1ccc(-c2nc(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5C=CCCCCC[C@H](N)C(=O)N4C3)c3oc4ccccc4c3n2)cc1.N.S=C(n1ccnc1)n1ccnc1>>CC(C)Oc1ccc(-c2nc(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5C=CCCCCC[C@H](NC(N)=S)C(=O)N4C3)c3oc4ccccc4c3n2)cc1,,C1CCOC1,,CCN(CC)CC,CO,val
US04914207,CCOP([O-])(=S)SCC.N#CCc1nc2ccccc2[nH]1>>NC(=S)Cc1nc2ccccc2[nH]1,,CN(C)C=O,,,,val
US20090042852A1,CCOC(=O)c1cc(C#N)c(N2C[C@@H]3C[C@H]2CN3C(=O)OC(C)(C)C)nc1C>>CCOC(=O)c1cc(C#N)c(N2C[C@@H]3C[C@H]2CN3)nc1C,,CCO,,C1COCCO1,Cl,val
US20090018117A1,CC(C)N=C=O.COc1ccc(C2CCCCC2)cc1-c1csc(NC(=O)N2CCN(C3CCCNC3)CC2)n1>>COc1ccc(C2CCCCC2)cc1-c1csc(NC(=O)N2CCN(C3CCCN(C(=O)NC(C)C)C3)CC2)n1,,ClCCl,,O,,val
US20110245224A1,CCC(O)CN(Cc1ccccc1)CC(C)O>>CCC1CN(Cc2ccccc2)CC(C)O1,,O=S(=O)(O)O,,O=C([O-])O.[Na+],,val
US20040224958A1,CCn1c(=O)c(C)cc2cnc(S(C)=O)nc21.CN1CCN(c2ccc(N)cc2)CC1>>CCn1c(=O)c(C)cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc21,,O,,,,val
US20150094305A1,CCOC(CC)(OCC)OCC.Nc1c(S)ncnc1Cl>>CCc1nc2c(Cl)ncnc2s1,,CCO,,,,val
US20100331326A1,Cc1ccncc1N.O=C=NCCCl>>Cc1ccncc1NC(=O)NCCCl,,Cc1ccccc1,ClC(Cl)Cl,CO,,val
US20160052888A1,COCCCCCC1CCc2cc([C@@H]3CC[C@]4(COC(=O)N4)C3)ccc2C1>>COCCCCCC1CCc2cc([C@@H]3CC[C@](N)(CO)C3)ccc2C1,,C1COCCO1,CCOC(C)=O,[Na+].[OH-],,val
US20130253004A1,Clc1cccc(-c2ccccc2)n1.Cn1ncc(Br)c1N>>Cn1ncc(Br)c1Nc1cccc(-c2ccccc2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20070027185A1,COCOc1cc(C2(C)OCCO2)ccc1C(=O)Nc1cccnc1C(=O)Nc1ccc(Cl)cn1>>CC(=O)c1ccc(C(=O)Nc2cccnc2C(=O)Nc2ccc(Cl)cn2)c(O)c1,,O,,O=C(O)C(F)(F)F,,val
US20080096240A1,COCOC.Oc1ccc(F)cc1Br>>COCOc1ccc(F)cc1Br,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150148340A1,CCOC(=O)c1cn(-c2ccc3c(c2)oc(=O)n3C)c(=O)n(C2CCCc3c2cccc3C(F)(F)F)c1=O>>Cn1c(=O)oc2cc(-n3cc(C(=O)O)c(=O)n(C4CCCc5c4cccc5C(F)(F)F)c3=O)ccc21,,CC#N,,CC(=O)O,Cl,val
US20120115813A1,BrCCCOCc1ccccc1.O=Cc1cc(Cl)cc(O)c1O>>O=Cc1cc(Cl)cc(OCCCOCc2ccccc2)c1O,,CS(C)=O,,[H-].[Na+],,val
US20120101110A1,BrP(Br)Br.OCc1ccccc1-n1nccn1>>BrCc1ccccc1-n1nccn1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20160060237A1,CCOC(=O)C(C)Cc1ccc(N(CC(C)C)CC(C)C)c(N)c1.Cc1ccc(N=C=O)cc1>>Cc1ccc(NC(=O)Nc2cc(CC(C)C(=O)O)ccc2N(CC(C)C)CC(C)C)cc1,,C1CCOC1,O,[Na+].[OH-],,val
US20120245137A1,O=S(=O)(c1cccc(C(F)(F)F)c1)C1CCC2(CC1)OCCO2.O=S(=O)(c1ccccc1)N(F)S(=O)(=O)c1ccccc1>>O=S(=O)(c1cccc(C(F)(F)F)c1)C1(F)CCC2(CC1)OCCO2,,C1CCOC1,,[Li]CCCC,,val
US20160002266A1,CC(C)(C)OC(=O)N1CCC2(CC1)CC2CNC(=O)Oc1ccc([N+](=O)[O-])cc1.c1n[nH]c2c1CNC2>>CC(C)(C)OC(=O)N1CCC2(CC1)CC2CNC(=O)N1Cc2cn[nH]c2C1,,CCO,,CCN(CC)CC,Cl,val
US20150284401A1,COS(=O)(=O)C(F)(F)F.c1ccc2cc([C@H]3[C@H](c4ccc5ccccc5c4)N4CCN3CC4)ccc2c1>>C[N+]12CCN(CC1)[C@@H](c1ccc3ccccc3c1)[C@@H]2c1ccc2ccccc2c1.O=S(=O)([O-])C(F)(F)F,,ClCCl,,,,val
US20120041012A1,CON(C)C(=O)c1cc(OCc2ccccc2)c(-c2ccc(F)cc2)c(OCc2ccccc2)c1>>CON(C)C(=O)c1cc(O)c(-c2ccc(F)cc2)c(O)c1,[Pd],CCOC(C)=O,,CCO,,val
US05470834,C=O.CC(C)CC(C(=O)O)C(=O)O>>C=C(CC(C)C)C(=O)O,,ClC(Cl)Cl,,CCNCC,,val
US05081287,CC(O)CCCCCCCCC=C(F)F>>CC(=O)CCCCCCCCC=C(F)F,,CC(C)=O,,O=S(=O)(O)O,O=[Cr](=O)=O,val
US20120214762A1,C/C(=N\N)c1cc(F)c(Br)cc1F>>Cc1n[nH]c2cc(Br)c(F)cc12,,OCCO,,O=C([O-])O.[Na+],,val
US20080153837A1,O=C(O)c1cccc2c1-c1ccccc1C2=O.[NH-]c1ccc(Br)cc1N>>O=C1c2ccccc2-c2c1cccc2-c1nc2ccc(Br)cc2[nH]1,,CC(=O)O,,,,val
US05252538,CCOC(=O)CC(=O)C(=O)OCC.Nc1nccnc1C=O>>CCOC(=O)c1cc2nccnc2nc1C(=O)OCC,,Cc1ccccc1,,C1CCNCC1,,val
US05342959,C1CN1.O=[N+]([O-])c1nccn1C[C@H]1CO1>>O=[N+]([O-])c1nccn1C[C@H](O)CN1CC1,,ClC(Cl)Cl,,,,val
US20050004094A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cn1cc([N+](=O)[O-])cn1>>Cn1cc(NC(=O)OC(C)(C)C)cn1,[Pd],C1CCOC1,,CCO,[H][H],val
US20070037809A1,COC(=O)c1cc(N)cc(-c2nc3ccncc3s2)c1.COc1cc(C(=O)Cl)cc(OC)c1OC>>COC(=O)c1cc(NC(=O)c2cc(OC)c(OC)c(OC)c2)cc(-c2nc3ccncc3s2)c1,,c1ccncc1,,,,val
US04960779,CC(=O)CCC(C)C.COc1ccc2ccc(N3C(=O)c4ccccc4C3O)nc2n1>>COc1ccc2ccc(N3C(=O)c4ccccc4C3CC(=O)CCC(C)C)nc2n1,,CN(C)C=O,,[H-].[Na+],,val
US20080269200A1,CC(=O)Cl.NC(=O)c1cc(-c2ccccc2)cc2c(CC3CCCNC3)c[nH]c12>>CC(=O)N1CCCC(Cc2c[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090163512A1,C=C(N=Cc1cc(F)ccc1C)O[Si](C)(C)C.CCOC(=O)C(C)(C)Oc1ccc(F)cc1/C=C1\C(=O)N(C(=O)OC(C)(C)C)c2cc(Cl)ccc21>>CCOC(=O)C(C)(C)Oc1ccc(F)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)Nc1cc(Cl)ccc12,,Cc1ccccc1,,,,val
US20150266834A1,Cc1c(N)cccc1CO[Si](C)(C)C(C)(C)C.O=C1CCC(=O)N1Cl>>Cc1c(CO[Si](C)(C)C(C)(C)C)ccc(Cl)c1N,,C1CCOC1,,CCCCCC,,val
US20110064662A1,CC[C@H](C)NC(=O)c1cc2ccccc2c(-c2cc(Br)ccc2Cl)n1.CI>>CC[C@H](C)c1c(C(=O)NC)nc(-c2cc(Br)ccc2Cl)c2ccccc12,,CS(C)=O,O,CN(C)C=O,[H-].[Na+],val
US20100069630A1,CC(C)(C)OC(=O)NC1CCNCC1.CC(C)=O>>CC(C)N1CCC(NC(=O)OC(C)(C)C)CC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20050020654A1,CCCc1nc2c(C)cc(Br)cc2n1CCOS(C)(=O)=O.COC(=O)c1cc(CC2SC(=O)NC2=O)ccc1O>>CCCc1nc2c(C)cc(Br)cc2n1CCOc1ccc(CC2SC(=O)NC2=O)cc1C(=O)OC,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05017573,CNCCNCc1ccccc1.O=S(=O)(c1ccccc1)N1CC1CBr>>CN1CCN(Cc2ccccc2)CC(NS(=O)(=O)c2ccccc2)C1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20100093730A1,NCc1ncco1.O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O>>O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)NCc1ncco1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US04012407,BrBr.Cc1cc2c(cc1C)C(=O)C=CC2=O>>Cc1cc2c(cc1C)C(=O)C(Br)=CC2=O,,CC(=O)O,,O,CC(=O)[O-].[Na+],val
US20160108019A1,CC(C)(C)OC(=O)N1CCC(OS(C)(=O)=O)CC1.O=c1cc(Br)cc[nH]1>>CC(C)(C)OC(=O)N1CCC(n2ccc(Br)cc2=O)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100056491A1,Nc1c[nH]c2cccnc12.ON=C(CCl)CCCl>>O/N=C1/CCN(c2c[nH]c3cccnc23)C1,,CC(C)(C)O,,,,val
US20040158067A1,CC(C)[Mg]Cl.O=Cc1c(F)cccc1Br>>CC(C)C(=O)c1c(F)cccc1Br,,C1CCOC1,,[Cl-].[NH4+],,val
US05389614,CC(=O)N([C@@H](CC(=O)O)C(=O)N[C@H](C(=O)O)C(C)C)N1C(=O)N[C@@H](Cc2ccc([N+](=O)[O-])cc2)C1=O>>CC(=O)N([C@@H](CC(=O)O)C(=O)N[C@H](C(=O)O)C(C)C)N1C(=O)N[C@@H](Cc2ccc(N)cc2)C1=O,,CO,,,,val
US20070238726A1,COc1ccc(Cn2nc(C)c3c(Oc4ccc(N)cn4)ccnc32)cc1.O=C(F)C1(C(=O)Nc2ccc(F)cc2)CC1>>COc1ccc(Cn2nc(C)c3c(Oc4ccc(N(C(=O)C5(C(N)=O)CC5)c5ccc(F)cc5)cn4)ccnc32)cc1,,O,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US05212187,CN(CCN)CCC(c1ccc(Cl)cc1)c1ccccn1.Cc1[nH]cnc1CSCCN.O=C(n1ccnc1)n1ccnc1>>Cc1[nH]cnc1CSCCNC(=O)NCCN(C)CCC(c1ccc(Cl)cc1)c1ccccn1,,CCOC(C)=O,CO,,,val
US20050245571A1,C[C@@H](c1c[nH]c2ccccc12)[C@@H](NC(=O)N1CCCN(C(=O)C(F)(F)F)CC1)C(=O)N1C[C@@H](CN(C)C)Cc2cc(Cl)ccc21>>C[C@@H](c1c[nH]c2ccccc12)[C@@H](NC(=O)N1CCCNCC1)C(=O)N1C[C@@H](CN(C)C)Cc2cc(Cl)ccc21,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US20080176906A1,CCOC(=O)CP(=O)(OCC)OCC.Cc1[nH]c(C=O)c(C#N)c1-c1ccc(C#N)cc1>>CCOC(=O)/C=C/c1[nH]c(C)c(-c2ccc(C#N)cc2)c1C#N,,CN(C)C=O,,[H-].[Na+],,val
US20030220350A1,CCOC(=O)CCNC(=O)c1ccc(C(NC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C3=CCCCC3)cc2)cc1>>O=C(O)CCNC(=O)c1ccc(C(NC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C3=CCCCC3)cc2)cc1,,C1CCOC1,CO,[Li+].[OH-],,val
US04873224,Nc1nccs1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>O=C(Nc1nccs1)Oc1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,,c1ccncc1,,val
US20070191405A1,CC(C)(C)N.O=C(Cl)c1cccc(Br)c1>>CC(C)(C)NC(=O)c1cccc(Br)c1,,ClCCl,,,,val
US20050176689A1,CC(=O)Cl.CCC1(CC)CC(C)(C)c2cc(Br)ccc2O1>>CCC1(CC)CC(C)(C)c2cc(Br)cc(C(C)=O)c2O1,,ClCCl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US04547371,CC(C)(C)OC(=O)CN.O=Cc1ccccc1>>CC(C)(C)OC(=O)CN=Cc1ccccc1,,c1ccccc1,,O=S(=O)([O-])[O-].[Mg+2],,val
US04420615,CCOC(=O)c1c(C)cc(C)nc1NCCN(C)C>>Cc1cc(C)c(CO)c(NCCN(C)C)n1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040142820A1,Cc1c(C(Br)CBr)c(C(F)(F)F)nn1C>>C#Cc1c(C(F)(F)F)nn(C)c1C,,Cc1ccccc1,,[K+].[OH-],,val
US20060058320A1,CCCC[Sn](C#CC1(O[Si](C)(C)C)CCCC1)(CCCC)CCCC.COc1ccc(CNc2nc(Cl)cc3nc(-c4ccco4)nn23)cc1OC>>COc1ccc(CNc2nc(C#CC3(O)CCCC3)cc3nc(-c4ccco4)nn23)cc1OC,,CN(C)C=O,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20090156572A1,CCOC(=O)c1ccc(N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)nc1>>CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(c2ccc(C(=O)O)cn2)C[C@H]1c1ccc(Cl)c(Cl)c1,,CO,,[Na+].[OH-],,val
US06562846B2,CCI.CCOC(=O)CCCCCCn1c(C)nc(-c2ccccc2)c1-c1ccccc1>>CCOC(=O)C(CC)CCCCCn1c(C)nc(-c2ccccc2)c1-c1ccccc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20130289020A1,CC(C)(C)OC(=O)N1CCO[C@H](C(=O)O)C1>>CC(C)(C)OC(=O)N1CCO[C@H](CO)C1,,C1CCOC1,,B,,val
US20060235031A1,O=C(O)c1ccc(NCC(O)c2ccccc2)c([N+](=O)[O-])c1>>O=C(O)c1ccc(NCC(=O)c2ccccc2)c([N+](=O)[O-])c1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US04665187,OC1(c2ccccc2)CCN(Cc2cncc(-c3ccc(F)cc3)c2)CC1>>Fc1ccc(-c2cncc(CN3CC=C(c4ccccc4)CC3)c2)cc1,,Cl,,,,val
US20150344471A1,CNc1ccc(C#N)cn1.O=S(=O)(Cl)c1ccn2nccc2c1>>CN(c1ccc(C#N)cn1)S(=O)(=O)c1ccn2nccc2c1,,C1CCOC1,,[H-].[Na+],,val
US20100227858A1,CS(=O)(=O)Cc1cc(Cl)nc(-c2ccc3[nH]ccc3c2)n1.C[C@H]1COCCN1>>C[C@H]1COCCN1N1C(CS(C)(=O)=O)=CC=NC1c1ccc2[nH]ccc2c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US05629406,CC(C)(C)OC(=O)N1CC[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1CO.O=[Cr](=O)=O>>CC(C)(C)OC(=O)N1CC[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1C(=O)O,,CC(C)=O,O,O=S(=O)(O)O,,val
US06313116B1,COc1cccc2sc(N)nc12.O=C(O)C(F)(F)F>>COc1cccc2sc(C(F)(F)F)nc12,,Clc1ccccc1Cl,,,,val
US20020019371A1,CI.COc1ccc(Br)c(C2OCCO2)c1>>COc1ccc(C)c(C2OCCO2)c1,,C1CCOC1,,[Li]CCCC,,val
US20080032986A1,Cc1ccc2c(N=C(c3ccccc3)C(O)(c3ccccc3)C(F)(F)F)cccc2n1>>Cc1ccc2c(NC(c3ccccc3)C(O)(c3ccccc3)C(F)(F)F)cccc2n1,,C1CCOC1,CO,[BH4-].[Na+],,val
US20110021522A1,CC1(C)OC(=O)CC(=O)O1.COc1ccc(C=O)c(O)c1OC>>COc1ccc2cc(C(=O)O)c(=O)oc2c1OC,,O,,,,val
US20120046289A1,COc1ccc(CN)cc1OC.O=C(O)C1(Cl)C=CC(Cl)=NN1>>COc1ccc(CNC(=O)c2cc(Cl)nnc2Cl)cc1OC,CN(C)c1ccncc1,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US05242914,CN(C)C(=O)[C@@H]1C[C@@H](OS(C)(=O)=O)CN1C(=O)OC(C)(C)C.COc1ccc(CS)cc1>>COc1ccc(CS[C@H]2C[C@@H](C(=O)N(C)C)N(C(=O)OC(C)(C)C)C2)cc1,,CN(C)C=O,,[Na+].[OH-],,val
US20160060197A1,CC(c1cccc(C(C)C2CC2)c1O)C1CC1.ClCBr>>CC(c1cccc(C(C)C2CC2)c1OCCl)C1CC1,,C1CCOC1,,[Na+].[OH-],,val
US05656660,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC1CCC(CN)CC1>>CC(C)(C)OC(=O)NCC1CCC(CN)CC1,,C1CCOC1,,,,val
US20150246912A1,COCC(=O)Cl.O=C1CCC(=O)N1O>>COCC(=O)ON1C(=O)CCC1=O,,ClCCl,,O=C([O-])O.[Na+],,val
US20110028466A1,CC(C)(C)[Si](C)(C)OCC1Cn2cc([N+](=O)[O-])nc2O1>>O=[N+]([O-])c1cn2c(n1)OC(CO)C2,,CCO,CO,Cl,N,val
US20050245503A1,Fc1cccc2c1CCc1ccncc1C2N=C=S.NNc1ncc(C(=O)O)cc1Cl>>O=C(O)c1cnc(NNC(=S)NC2c3cnccc3CCc3c(F)cccc32)c(Cl)c1,,CC(=O)N(C)C,,,,val
US20060241302A1,Fc1ccc(F)c(C(Sc2ccc(Cl)cc2)c2cc(Cl)ncc2Cl)c1.NCCOCCO>>OCCOCCNc1cc(C(Sc2ccc(Cl)cc2)c2cc(F)ccc2F)c(Cl)cn1,,CO,ClCCl,C1COCCO1,,val
US20030216444A1,BrBr.Cc1ccc2c(c1)OCO2>>Cc1cc2c(cc1Br)OCO2,,ClCCl,,c1ccncc1,,val
US05281593,COC(=O)c1cccc(C2OCCO2)c1>>OCc1cccc(C2OCCO2)c1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05753664,CN(C)c1cnn(C(C)(C)C)c(=O)c1C=O.NN>>CC(C)(C)n1ncc2[nH]ncc2c1=O,,CCO,,,,val
US20100130495A1,C=O.Cc1nccn1-c1ccc(Nc2nc3c(c(Cc4ccccc4)n2)CNCC3)cc1>>Cc1nccn1-c1ccc(Nc2nc3c(c(Cc4ccccc4)n2)CN(C)CC3)cc1,,CO,,CC(=O)O,,val
US20150119380A1,Cc1cnc(N)c(C)n1.O=C(CBr)c1cc2ccc(F)cc2oc1=O>>Br.Cc1cn2cc(-c3cc4ccc(F)cc4oc3=O)nc2c(C)n1,,CC#N,CCOCC,,,val
US20070149574A1,CC(=O)Nc1cc(CO)ccn1.CS(=O)(=O)Cl>>CC(=O)Nc1cc(COS(C)(=O)=O)ccn1,,C1CCOC1,,CCN(CC)CC,O,val
US20030119842A1,CC(=O)Cl.Nc1ncccn1.O=Cc1ccccc1.[C-]#[N+]C(C)(C)C>>CC(=O)[n+]1c(-c2ccccc2)c(NC(C)(C)C)n2cccnc21.[Cl-],,[O-][Cl+3]([O-])([O-])O,,,,val
US20080207654A1,CCCc1nc(C)c(-c2ccc(OC(C)C)cc2)c(=O)n1Cc1ccc(-c2ccccc2C#N)c(F)c1.O=C([O-])O.[NH3+]O>>CCCc1nc(C)c(-c2ccc(OC(C)C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)c(F)c1,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20150344490A1,CC(=O)c1ccc(OCc2ccccc2)cc1.CNN.COC(OC)N(C)C>>Cn1nccc1-c1ccc(OCc2ccccc2)cc1,,CCOC(C)=O,CN(C)C=O,,,val
US20100317686A1,CCCC[Sn](CCCC)(CCCC)c1cn(Cc2ccccc2)cn1.O=C(Nc1ccccn1)c1cn2cc(I)ccc2n1>>O=C(Nc1ccccn1)c1cn2cc(-c3cn(Cc4ccccc4)cn3)ccc2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20090093454A1,C[C@H]1CNC[C@@H](C)N1.Fc1cccc2nc(CN3CCC[C@H]4CCc5cccnc5[C@H]43)cn12>>C[C@H]1CN(c2cccc3nc(CN4CCC[C@H]5CCc6cccnc6[C@H]54)cn23)C[C@@H](C)N1,,CS(C)=O,,,,val
US20130216477A1,CC(C)(C)OC(=O)CCC(N)(CCC(=O)OC(C)(C)C)CCC(=O)OC(C)(C)C.O=C(Br)CBr>>CC(C)(C)OC(=O)CCC(CCC(=O)OC(C)(C)C)(CCC(=O)OC(C)(C)C)NC(=O)CBr,,ClCCl,,CCN(CC)CC,,val
US20050230255A1,CCCCCCCCCCCCOS(=O)(=O)[O-].NC(CO)(CO)CO.NC(N)=O.OCC(O)CO.[Na+]>>CCCCCCCCCCCCOS(=O)(=O)[O-].NC(CO)(CO)CO.NCC(=O)O.[Na+],,OCC(O)CO,,,,val
US20160031871A1,CCN(C(=O)OC(C)(C)C)c1ncc(CN2CCC(c3ccccc3)CC2)s1>>CCNc1ncc(CN2CCC(c3ccccc3)CC2)s1,,C1COCCO1,,Cl,,val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2ccc(O)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21.O=S(=O)(Cl)c1cccc2cccnc12>>CC(C)(C)OC(=O)n1c(-c2ccc(OS(=O)(=O)c3cccc4cccnc34)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21,,CC#N,,CCN(CC)CC,,val
US20070213341A1,C=C(C)C1N(CC(=O)F)C(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12.NCCO>>C=C(C)C1N(CC(=O)NCCO)C(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12,CN(C)c1ccncc1,C1CCOC1,,CN1CCOCC1,,val
US20090030012A1,CC(C)(C)OC(=O)N1CC=C(c2cncc(Cl)n2)CC1.CC(C)(C)c1cc(B(O)O)cc(C(C)(C)C)c1>>CC(C)(C)OC(=O)N1CC=C(c2cncc(-c3cc(C(C)(C)C)cc(C(C)(C)C)c3)n2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20100286145A1,C=C(C)c1cc(CN)c(C)nc1C>>Cc1nc(C)c(C(C)C)cc1CN,,CCO,,Cl,[BH4-].[Na+],val
US20140005418A1,COC(=O)C1CCOc2cc(Oc3ccc(C(=O)O)cc3)c(C#N)cc21.NC1Cc2ccccc2C1>>COC(=O)C1CCOc2cc(Oc3ccc(C(=O)NC4Cc5ccccc5C4)cc3)c(C#N)cc21,CN(C)c1ccncc1,CN1CCCC1=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140315888A1,CN1CCN(c2nc3ncccc3nc2Cl)CC1.NN>>CN1CCN(c2nc3ncccc3nc2NN)CC1,,CCO,,O,,val
US20160168139A1,BrC(Br)(Br)Br.CC(CCO)Nc1ccc2c(c1)Sc1cccc(-c3cc(N4CCOCC4)cc(=O)[nH]3)c1S2>>CC(CCBr)Nc1ccc2c(c1)Sc1cccc(-c3cc(N4CCOCC4)cc(=O)[nH]3)c1S2,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04242121,CC(C)c1cc(O)cc(C(C)C)c1.O=C(O)c1cc(Cl)ccc1Cl>>CC(C)c1cc(Oc2ccc(Cl)cc2C(=O)O)cc(C(C)C)c1,,Cc1ccccc1C,,[H-].[Na+],,val
US20070043036A1,C1COCCN1.Cc1c(C(C)O)cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)n1-c1cccc(C(F)(F)F)c1>>Cc1c(C(C)N2CCOCC2)cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)n1-c1cccc(C(F)(F)F)c1,,ClCCl,O,O=S(Cl)Cl,,val
US05401851,CCCCCCC(Br)C(=O)OCC.O=[N+]([O-])c1c[nH]cn1>>CCCCCCC(C(=O)OCC)n1cnc([N+](=O)[O-])c1,,CN(C)C=O,,[H-].[Na+],,val
US20150203453A1,CCOC(=O)c1ccnc(CNCC(=O)OC(C)(C)C)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)c1ccnc(CN(CC(=O)OC(C)(C)C)C(=O)C(F)(F)F)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150045368A1,CC1(C)OC(=O)NC1c1cccnc1.O=C(Nc1cccc2cccnc12)c1ccc(I)cc1>>CC1(C)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)C1c1cccnc1,[Cu]I,C1COCCO1,,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20020016368A1,C=Cc1ccc(CN(CCCCCCC(=O)OCC)S(C)(=O)=O)cc1.O=[Os](=O)(=O)=O>>CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(C=O)cc1,O=[Os](=O)(=O)=O,C1COCCO1,O,C[N+]1([O-])CCOCC1,,val
US20090253684A1,CCOC(=O)CCCOc1cccc(CCCCCCBr)c1CCC(=O)OCC.O=C1CCN(C(=O)c2cc(O)cc(-c3ccc4c(c3)OCO4)c2)CCN1>>O=C(O)CCCOc1cccc(CCCCCCOc2cc(C(=O)N3CCNC(=O)CC3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O,,CC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20100240658A1,CCOC(=O)c1ccc(N2CCCCC2C)c([N+](=O)[O-])c1>>CCOC(=O)c1ccc(N2CCCCC2C)c(N)c1,[Pd],CCOC(C)=O,CO,,,val
US04668812,C=C[Si](OC(C)C)(OC(C)C)OC(C)C.CC(C)(C)O[SiH](OC(C)(C)C)OC(C)(C)C>>CC(C)O[Si](C=C[Si](OC(C)(C)C)(OC(C)(C)C)OC(C)(C)C)(OC(C)C)OC(C)C,,Cc1ccccc1C,,,,val
US20120277208A1,CNC(=O)c1noc(-c2cnc(Oc3cc(OC4(CO[Si](C)(C)C(C)(C)C)CCC4)cc(C(=O)Nc4ccn(C)n4)c3)cn2)n1>>CNC(=O)c1noc(-c2cnc(Oc3cc(OC4(CO)CCC4)cc(C(=O)Nc4ccn(C)n4)c3)cn2)n1,,CCOC(C)=O,,C1CCOC1,Cl,val
US20150218096A1,COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(NC(=O)OC(C)(C)C)cnc23)c(F)c1>>CC(C)(C)OC(=O)Nc1cnc2c(-c3ccc(C(=O)O)cc3F)nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1,,C1CCOC1,O,Cl,[Li]O,val
US04332808,OC1(c2cccc3[nH]ccc23)CCCN(CC2CC2)C1>>C1=C(c2cccc3[nH]ccc23)CN(CC2CC2)CC1,,Cl,O,,,val
US20090312369A1,COC(=O)Cl.Cc1ccc(Cl)cc1[C@H](OCCN)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1>>COC(=O)NCCO[C@@H](c1cc(Cl)ccc1C)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20130029938A1,CCCC[C@]1(CC)CS(=O)(=O)c2cc(CCC(=O)O)c(OC)cc2[C@@H](c2ccccc2)N1>>CCCC[C@]1(CC)CS(=O)(=O)c2cc(CCCO)c(OC)cc2[C@@H](c2ccccc2)N1,,C1CCOC1,,,,val
US20140093960A1,CCOC(=O)C(=O)CBr.NC(=S)c1cccc(OCc2ccccc2)c1OCc1ccccc1>>CCOC(=O)c1csc(-c2cccc(OCc3ccccc3)c2OCc2ccccc2)n1,,CCO,,O=C([O-])O.[Na+],,val
US20160176850A1,Clc1cc(Cl)nc(Cl)n1.c1cnc2[nH]nc(C3CCNCC3)c2c1>>Clc1cc(N2CCC(c3n[nH]c4ncccc34)CC2)nc(Cl)n1,,CO,,Cl,,val
US04508926,CCC(=O)c1ccc(O)cc1.[Li]c1ccc(Br)cc1>>CCC(O)(c1ccc(O)cc1)c1ccc(Br)cc1,,CC(=O)O,,C1CCOC1,,val
US06818642B2,O=[N+]([O-])c1cnc2ccc(Cl)nn12.Oc1ccc(CNc2ncncc2Cl)cc1>>O=[N+]([O-])c1cnc2ccc(Oc3ccc(CNc4ncncc4Cl)cc3)nn12,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150051171A1,COc1ccc(-n2ccc(O)n2)cc1.Cn1nnn(-c2cccc(C3CC3)c2CBr)c1=O>>COc1ccc(-n2ccc(OCc3c(C4CC4)cccc3-n3nnn(C)c3=O)n2)cc1,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20120190677A1,CC(C)N.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CC(C)NS(=O)(=O)c1ccc([N+](=O)[O-])cc1,,ClCCl,,CCN(CC)CC,,val
US20100075948A1,N#CCc1ccc(Br)cc1.O=Cc1cccc(Cl)c1F>>N#C/C(=C\c1cccc(Cl)c1F)c1ccc(Br)cc1,,CO,,C[O-].[Na+],,val
US20040242593A1,CCCCC1(c2cc(OC)cc(OC)c2)SCCS1.COc1cc(OC)cc(C(=O)C2CCCCC2)c1>>COc1cc(OC)cc(C2(C3CCCCC3)SCCS2)c1,,CCCCCC,CCOC(C)=O,,,val
US20130203730A1,NC(=O)c1cc(C2C=CCC2)ccc1Cl>>NC(=O)c1cc(C2CCCC2)ccc1Cl,[Pt],CCOC(C)=O,,,,val
US20120264711A1,CC(C)(C)OC(=O)N1CCC2(CC2)C1.COC(=O)NC(C(=O)N1C2CCC(C2)C1c1ncc(-c2ccc3cc(B4OC(C)(C)C(C)(C)O4)ccc3c2)[nH]1)C(C)C.COC(=O)NC(C(=O)N1CC2(CC2)CC1c1ncc(-c2ccc3cc(-c4ccc(-c5cnc(C6C7CCC(C7)N6C(=O)C(NC(=O)OC)C(C)C)[nH]5)cc4)ccc3c2)[nH]1)C(C)C>>COC(=O)NC(C(=O)N1C2CCC(C2)C1c1ncc(-c2ccc3cc(-c4ccc(-c5cnc(C6CC7(CC7)CN6C(=O)OC(C)(C)C)[nH]5)cc4)ccc3c2)[nH]1)C(C)C,,CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110245224A1,Cc1c(C(=NO)c2nccs2)c(F)c(C)c(N2C[C@H](C)O[C@H](C)C2)c1C(=O)O>>Cc1c(N2C[C@H](C)O[C@H](C)C2)c(C(=O)O)cc2c(-c3nccs3)noc12,,CN(C)C=O,,[I-].[K+],,val
US20110301161A1,CC(C)(C)Nc1ccc(Br)cc1[N+](=O)[O-].CC1(C)OB(c2cnc(N)nc2)OC1(C)C>>CC(C)(C)Nc1ccc(-c2cnc(N)nc2)cc1[N+](=O)[O-],c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20030069271A1,CCc1c(O[Si](C)(C)C(C)(C)C)nc2ccc(F)cc2c1OCC(F)(F)F.[Li]C1CC1>>CCc1c(OC#CC2CC2)c2cc(F)ccc2[nH]c1=O,,CCOCC,CCOCC,,,val
US20110039829A1,CCOC(=O)COc1cc(C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)N2CCN(C(=O)OCC)CC2)nn1-c1cccc(OC)c1>>CCOC(=O)COc1cc(C(=O)N[C@@H](CCC(=O)O)C(=O)N2CCN(C(=O)OCC)CC2)nn1-c1cccc(OC)c1,,ClCCl,O=C(O)C(F)(F)F,Cc1ccccc1,,val
US20150126734A1,CCCCN(CCCC)C(=O)Cl.O=C(O)N1CCOCC1>>CCCCN(CCCC)C(=O)N1CCOCC1,,O,,c1ccncc1,,val
US20120129806A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(O)C1Cc2c(Cl)cc(Cl)cc2CN1>>CC(C)(C)OC(=O)N1Cc2cc(Cl)cc(Cl)c2CC1C(=O)O,,C1COCCO1,O,[Na+].[OH-],,val
US05126125,C/C(=N\[Si](C)(C)C)O[Si](C)(C)C.Oc1cc2cc[nH]c2cc1O>>C[Si](C)(C)Oc1[nH]c2ccccc2c1O[Si](C)(C)C,,ClCCl,,,,val
US20050085639A1,CCCS([NH-])(=O)=O.COc1ccccc1Oc1c(Cl)nc(-c2ncccn2)nc1Cl>>CCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(Cl)c1Oc1ccccc1OC,,CS(C)=O,,Cl,,val
US20030176418A1,CCCCC1CCNCC1.O=C1COc2cc(F)ccc2N1CCCCl>>CCCCC1CCN(CCCN2C(=O)COc3cc(F)ccc32)CC1,,CCCCCCC,CCOC(C)=O,[I-].[K+],O=C([O-])O.[Na+],val
US20050085465A1,COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1O.Cc1ccc(S(=O)(=O)OCC2CO2)cc1>>COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OC[C@H]1CO1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US04923891,CCCc1c(OCCCSCC2COC(CCC(=O)O)(CCC(=O)O)S2)ccc(C(C)=O)c1O.O=C(OO)c1ccccc1Cl>>CCCc1c(OCCCS(=O)CC2COC(CCC(=O)O)(CCC(=O)O)S2)ccc(C(C)=O)c1O,,ClCCl,,,,val
US05179212,Cc1ccc(S(=O)(=O)OC[C@@H](O)CC#N)cc1.Cl>>Cc1ccc(S(=O)(=O)OC[C@@H](O)CCN)cc1.Cl,[Pd],CO,,[H][H],,val
US20030134997A1,C1CCNC1.C=Cc1ccc(CCl)cc1>>C=Cc1ccc(CN2CCCC2)cc1,,CCCCCC,,,,val
US20120214803A1,Nc1c(Cl)ccc2cccnc12.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(Nc1c(Cl)ccc2cccnc12)c1ccccc1,CN(C)c1ccncc1,CCCCC,,,,val
US06359056B1,OCCCCCCCCCCCBr.Oc1ccncc1>>CCCCCCCCCCC(O)Oc1ccncc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140378459A1,CC(C)(C)[Si](C)(C)Oc1ccc(CC(=O)OCc2ccccc2)c(C2CC2)c1>>O=C(Cc1ccc(O)cc1C1CC1)OCc1ccccc1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20020019538A1,O=C(O)c1ccccc1I.O=[N+]([O-])O>>O=C(O)c1cc([N+](=O)[O-])ccc1I,,O=S(=O)(O)O,,,,val
US20040127538A1,CC(=O)O.N#Cc1ccc2[nH]nc(-c3cccc(F)c3)c2c1.O=S(=O)(O)O>>O=C(O)c1ccc2[nH]nc(-c3cccc(F)c3)c2c1,,O,,,,val
US20090169558A1,CSc1nc2[nH]c(-c3ccnc(/C=C/c4ccccc4)c3)cc2c(=O)[nH]1.NCC(O)CO>>O=c1[nH]c(NCC(O)CO)nc2[nH]c(-c3ccnc(/C=C/c4ccccc4)c3)cc12,,CCOC(C)=O,,,,val
US20100210704A1,CC(=O)Nc1cc(OC(F)(F)C(F)OC(F)(F)C(F)(F)C(F)(F)F)nn1-c1cc(SCC(F)(F)F)c(C)cc1F.O=C(OO)c1cccc(Cl)c1>>CC(=O)Nc1cc(OC(F)(F)C(F)OC(F)(F)C(F)(F)C(F)(F)F)nn1-c1cc(S(=O)CC(F)(F)F)c(C)cc1F,,ClC(Cl)Cl,,,,val
US20150368245A1,COC(=O)[C@@H]1CC[C@@H](NC(=O)OCc2ccccc2)CC1>>O=C(N[C@@H]1CC[C@@H](C(=O)O)CC1)OCc1ccccc1,,CO,,Cl,[Na+].[OH-],val
US20120258946A1,COCCOc1ccc(N)cc1F.O=C(Cl)Oc1ccccc1>>COCCOc1ccc(NC(=O)Oc2ccccc2)cc1F,,CC(C)=O,,c1ccncc1,,val
US20160031873A1,CCNCC.O=S(=O)(Cl)c1cc(C(F)(F)F)ccc1F>>CCN(CC)S(=O)(=O)c1cc(C(F)(F)F)ccc1F,,ClCCl,,,,val
US06545033B1,CC(=O)C1CCCCC1=O.NNc1c(Cl)cc(C(F)(F)F)cc1Cl>>Cc1c2c(nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl)CCCC2,,CCO,,,,val
US20140213586A1,COc1cncc(NC(C(=O)c2c[nH]c3c(CCOC(C)=O)cccc23)c2cnc(OC)cn2)c1>>COc1cncc(NC(C(=O)c2c[nH]c3c(CCO)cccc23)c2cnc(OC)cn2)c1,,C1CCOC1,CO,O=C([O-])[O-].[K+].[K+],,val
US20040063170A1,CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.COC(=O)c1ccc(Cc2ccccc2O)cc1>>COC(=O)c1ccc(Cc2ccccc2O[C@@H]2O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)cc1,,Cc1ccccc1,ClCCl,,,val
US20130123252A1,COC(=O)c1sc(-c2ccccc2)cc1N1C(=O)CC(N)CC1C1CCCCC1.O=C(Cl)COc1ccccc1>>COC(=O)c1sc(-c2ccccc2)cc1N1C(=O)CC(NC(=O)COc2ccccc2)CC1C1CCCCC1,,ClCCl,,,,val
US20160176868A1,CC(C)(C)[Si](OCCCBr)(c1ccccc1)c1ccccc1.COC(=O)CC(=O)OC>>COC(=O)C(CCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)C(=O)OC,,C1CCOC1,O,[H-].[Na+],,val
US20030232832A1,O=S(Cl)Cl.O=c1c2ccc(Cl)n2nc(C(O)C2CC2)n1Cc1ccccc1>>O=c1c2ccc(Cl)n2nc(C(Cl)C2CC2)n1Cc1ccccc1,,ClCCl,,c1ccncc1,,val
US20050282819A1,CCOC(=O)Cc1ccc2c(c1)CCC(=O)C2.OCCO>>CCOC(=O)Cc1ccc2c(c1)CCC1(C2)OCCO1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140163000A1,CC1CN(C(=O)OC(C)(C)C)CCN1c1ccncc1[N+](=O)[O-]>>CC1CNCCN1c1ccncc1[N+](=O)[O-],,ClCCl,,O=C(O)C(F)(F)F,,val
US20150038672A1,Cc1ccc(C(NCCCC[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(N)=O)(c2ccccc2)c2ccccc2)cc1>>NCCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(N)=O,,ClCCl,,,,val
US04495178,CN(C(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(=O)O>>CN(C(=O)OC(C)(C)C)[C@@H](CC1CCCCC1)C(=O)O,[Rh],C1CCOC1,,[H][H],,val
US20040072844A1,CC(C)(C)OC(=O)N1CC=C(c2cccc3[nH]ccc23)CC1>>CC(C)(C)OC(=O)N1CCC(c2cccc3[nH]ccc23)CC1,[Pd],CCO,,,,val
US20080070920A1,CC(C)c1c(Cl)nc(OCc2ccccc2)nc1OCc1ccccc1.Cc1cc(C#N)cc(CC#N)c1>>Cc1cc(C#N)cc(C(C#N)c2nc(OCc3ccccc3)nc(OCc3ccccc3)c2C(C)C)c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20120316208A1,OCCOCCOCCO.[N-]=[N+]=[N-]>>[N-]=[N+]=NCCOCCOCCO,[Pd],CO,,,,val
US20120142717A1,CI.O=c1nc(OCCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)[nH]cc1Cc1cncnc1>>Cn1cc(Cc2cncnc2)c(=O)nc1OCCc1cc(F)c(Oc2ccc(Cl)c(C(F)(F)F)c2)c(F)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20050282812A1,CCC1CN(C(C(=O)OC)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cc(Br)ccc2N1.CCOC(=O)Cl>>CCOC(=O)N1c2ccc(Br)cc2N(C(C(=O)OC)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1CC,,ClCCl,,c1ccncc1,,val
US20080221197A1,CC(C)c1ccccc1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12>>CC(C)c1ccccc1-c1c[nH]c2ccccc12,,CO,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20070208052A1,II.OCCc1ccccc1>>ICCc1ccccc1,,ClCCl,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040142983A1,O=C(O)CCc1ccc(O)cc1>>OCCCc1ccc(O)cc1,,C1CCOC1,O,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20060258714A1,CCl.[N-]=[N+]=NC[C@H]1CCc2cc(F)cc(-c3ccccc3-c3ccccc3)c2O1>>Cl.NC[C@H]1CCc2cc(F)cc(-c3ccccc3-c3ccccc3)c2O1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120122838A1,COC(=O)COc1nc([C@H](C)Nc2ncnc3[nH]cnc23)cc2cccc(Cl)c12>>C[C@H](Nc1ncnc2[nH]cnc12)c1cc2cccc(Cl)c2c(OCC(=O)O)n1,,CCO,O,[Li+].[OH-],,val
US20070232627A1,O=C(Nc1ncc(Br)s1)c1ccc(Cl)c([N+](=O)[O-])c1.Oc1ccc(S)cc1>>O=C(Nc1ncc(Br)s1)c1ccc(Sc2ccc(O)cc2)c([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140134133A1,CCOC(CBr)OCC.Nc1ccc(Br)nn1>>Brc1ccc2nccn2n1,Cc1ccc(S(=O)(=O)O)cc1,CCO,O,,,val
US20070248672A1,CC(=O)Cl.COc1ccc(-c2c(N)n(C)c3cc(OC)c(OC)cc23)cc1>>COc1ccc(-c2c(CNC(C)=O)[nH]c3cc(OC)c(OC)cc23)cc1,,ClCCl,,CCN(CC)CC,,val
US20120295884A1,CC(C)(C)OC(=O)N1C[C@](C)(F)C[C@H]1C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N1C[C@](C)(F)C[C@H]1C(=O)O,[Pd],C1CCOC1,,,,val
US20060264429A1,Cc1ccc2c(C3=CCN(C(=O)OC(C)(C)C)CC3)cc(F)cc2n1>>Cc1ccc2c(C3CCN(C(=O)OC(C)(C)C)CC3)cc(F)cc2n1,[Pd],CCO,,,,val
US20050113419A1,CCCc1c(OCCCNC)ccc2c(C(F)(F)F)noc12.CN=C=O>>CCCc1c(OCCCN(C)C(=O)NC)ccc2c(C(F)(F)F)noc12,,c1ccncc1,,,,val
US04927838,COc1cccc(-c2c(CO)ccc3ccc(OC)cc23)c1>>COc1cccc(-c2c(C=O)ccc3ccc(OC)cc23)c1,,ClCCl,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US20160271081A1,CCOC(=O)C(CCc1ccccc1)(Cc1ccccc1)C(=O)OCC>>CCOC(=O)C(CCc1ccccc1)Cc1ccccc1,,CS(C)=O,,[Cl-].[Li+],,val
US20020037907A1,O[C@@H](CNCC1CCN(CCC(F)(F)F)CC1)COc1ccc(OCc2ccccc2)cc1>>Oc1ccc(OC[C@@H](O)CNCC2CCN(CCC(F)(F)F)CC2)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US20130296302A1,Nc1c(-c2ccncc2)cccc1[N+](=O)[O-]>>Nc1cccc(-c2ccncc2)c1N,[Pd],CCOC(C)=O,,,,val
US20110245255A1,Cc1nc(N2CCN(C(=O)OC(C)(C)C)CC2)c2nc(-c3ccccc3Cl)n(CC(C)(C)O)c2n1>>Cc1nc(N2CCNCC2)c2nc(-c3ccccc3Cl)n(CC(C)(C)O)c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080027068A1,CC(C)c1ccc(C(=O)C=O)cc1.CNN=CC(C)=O>>CC(=O)c1nn(C)c(-c2ccc(C(C)C)cc2)c1O,,CC(=O)O,,CCCCCC,CCOC(C)=O,val
US20030013754A1,CCOC(=O)C(CC(=O)c1ccccc1)C(C)=O.Cc1cccc(N)c1>>CCOC(=O)c1cc(-c2ccccc2)n(-c2cccc(C)c2)c1C,,CCO,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110046133A1,Nc1ccc(C(=O)Nc2nccc3ccccc23)cc1[N+](=O)[O-]>>Nc1ccc(C(=O)Nc2nccc3ccccc23)cc1N,O=[Pt],CO,,,,val
US20150315227A1,COC(C)(OC)N1CCOCC1.Nc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](CO)O1>>CC(=Nc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](CO)O1)N1CCOCC1,,CO,,O,c1ccncc1,val
US20120184543A1,CN1CCN(C[C@H](O)CNC(=O)OCc2ccccc2)CC1>>CN1CCN(C[C@H](O)CN)CC1,[Pd],CO,,[H][H],,val
US20090062518A1,CC(=O)n1[nH]c(=O)c(Cc2ccc(OC(C)C)cc2)c1C.CC(C)(C)C(=O)OC[C@H]1O[C@H](Br)[C@H](OC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@@H]1OC(=O)C(C)(C)C>>CC(=O)n1nc(O[C@@H]2O[C@H](COC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@H](OC(=O)C(C)(C)C)[C@H]2OC(=O)C(C)(C)C)c(Cc2ccc(OC(C)C)cc2)c1C,,C1CCOC1,CC#N,O=C([O-])[O-].[K+].[K+],,val
US04829067,COC(=O)C(Br)c1ccc(Cl)cc1.COC(=O)c1cccc(C=O)c1O>>O=C(O)c1cccc2cc(-c3ccc(Cl)cc3)oc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070135457A1,CC(=O)c1ccc(CCC#N)cc1.C[Mg]Cl>>CC(C)(O)c1ccc(CCC#N)cc1,,C1CCOC1,,,,val
US20120309724A1,CCOC(=O)[C@H](O)[C@H](N)Cc1ccccc1Cl.O=C(O)c1cc(Br)ccn1>>CCOC(=O)[C@H](O)[C@@H](Cc1ccccc1Cl)NC(=O)c1cc(Br)ccn1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130053341A1,COc1ccc2cc(Cl)nc(OCc3ccccc3)c2c1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.N#N>>COc1ccc2cc(-c3cccnc3)nc(OCc3ccccc3)c2c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US06783812B2,CCCCCCCCCCc1cnc(-c2ccc(O)cc2)nc1.C[Si](C)(C)CC[Si](C)(C)CCCCCCCCO>>CCCCCCCCCCc1cnc(-c2ccc(OCCCCCCCC[Si](C)(C)CC[Si](C)(C)C)cc2)nc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160016935A1,COc1ccc(COc2ccnc(F)c2)cc1.C[C@@H]1CC[C@@H](O)CN1C(=O)OC(C)(C)C>>COc1ccc(COc2ccnc(O[C@@H]3CC[C@@H](C)N(C(=O)OC(C)(C)C)C3)c2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100029705A1,Cc1c(C)c(C)c2c(c1C)CC(NC(=O)c1ccccc1)C2>>Cc1c(C)c(C)c2c(c1C)CC(NCc1ccccc1)C2,,C1CCOC1,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05360807,Cc1cccc(CN)n1.O=[N+]([O-])c1cccnc1Cl>>Cc1cccc(CNc2ncccc2[N+](=O)[O-])n1,,CCO,,O=C([O-])O.[Na+],,val
US04076818,C#CCO.[N-]=[N+]=C1C(=O)Nc2c1cccc2C(F)(F)F>>O=c1[nH]c2c(C(F)(F)F)cccc2c2cc(CO)nn12,,CCOCC,,,,val
US20040106800A1,CCCN(CC)S(=O)(=O)N=C=S.Clc1ccc(C2=NNCC2c2ccccc2)cc1>>CCCN(CC)S(=O)(=O)NC(=S)N1CC(c2ccccc2)C(c2ccc(Cl)cc2)=N1,,ClCCl,,,,val
US20080113978A1,CC(=O)CC(C)=O.CCC(CC)c1cc(C)nn2c(-c3sc(NN)nc3C)c(C)nc12>>CCC(CC)c1cc(C)nn2c(-c3sc(-n4nc(C)cc4C)nc3C)c(C)nc12,,CC(=O)O,,,,val
US20130045964A1,CC(C)(C)OC(=O)NCCNC(=O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1.O=C(O)C(F)(F)F>>NCCNC(=O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20140187545A1,C1COCCN1.Cc1nn2c(N)cc(Cl)nc2c1Cc1cccc(C(F)(F)F)c1C>>Cc1nn2c(N)cc(N3CCOCC3)nc2c1Cc1cccc(C(F)(F)F)c1C,,CCO,,,,val
US04751297,C1=COCCC1.CSCSC(=S)SC1NC(=O)[C@H]1C(C)O>>CSCSC(=S)SC1NC(=O)[C@H]1C(C)OC1CCCCO1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20150210688A1,CN(C)S(=O)(=O)Cl.Cc1cn[nH]c1>>Cc1cnn(S(=O)(=O)N(C)C)c1,,ClCCl,,CCN(CC)CC,,val
US06093718,O=C(C1CCN(c2ccncn2)C1)N1CCNCC1.O=S(=O)(Cl)c1ccc(Br)cc1>>O=C(C1CCN(c2ccncn2)C1)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20100184741A1,CC1(C)OB(c2cc(S(=O)(=O)N3CCCCc4ccccc43)ccc2Cl)OC1(C)C.Cc1cc(Cl)ncc1Br>>Cc1cc(Cl)ncc1-c1cc(S(=O)(=O)N2CCCCc3ccccc32)ccc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20100227862A1,O=C1NC(=O)C2(CCN(Cc3ccccc3)CC2)C1c1ccc(F)cc1>>Fc1ccc(C2CNCC23CCN(Cc2ccccc2)CC3)cc1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20110288067A1,CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Oc3ccc4cc[nH]c4c3)nc12.CI>>CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Oc3ccc4ccn(C)c4c3)nc12,,CN(C)C=O,,[H-].[Na+],,val
US20040039038A1,CN(Cc1cccc(Br)c1)C(=O)c1ccccc1.O=Cc1ccc(B(O)O)cc1>>CN(Cc1cccc(-c2ccc(C=O)cc2)c1)C(=O)c1ccccc1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20020198189A1,CCCC=O.Cl.Cl.NCCc1c[nH]cn1>>CCCC1NCCc2[nH]cnc21.Cl.Cl,,CO,O,Cl,[Na+].[OH-],val
US04048318,CC(C)(C)C(=O)C(Br)c1ccccc1.Oc1ccc(Cl)cc1>>CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)c1ccccc1,,CCO,CCOC(C)=O,[Na],,val
US20090275534A1,CCN=C=O.Nc1cnc2ccc(Cl)nc2n1>>CCNC(=O)Nc1cnc2ccc(Cl)nc2n1,,C1COCCO1,,,,val
US20150284395A1,CCn1nccc1CC#N.COC(OC)N(C)C>>CCn1nccc1C(C#N)=CN(C)C,,Cc1ccccc1,,,,val
US20090197871A1,CC(C)(C)OC(=O)N1CCC(Cc2cccc(-c3cccc(CN)c3)c2)CC1>>CN1CCC(Cc2cccc(-c3cccc(CN)c3)c2)CC1,,CCOCC,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05158971,C[Si](C)(C)N=C=O.ONCc1ccc(Sc2ccccc2)s1>>NC(=O)N(O)Cc1ccc(Sc2ccccc2)s1,,C1COCCO1,,,,val
US20150152216A1,CC[SiH](Cl)CC.CN(C)c1ccc(C(O)c2ccccc2Br)cc1>>CC[Si]1(CC)OC(c2ccc(N(C)C)cc2)c2ccccc21,,C1CCOC1,,[Li]CCCC,,val
US20150337004A1,CC(C)(C)OC(=O)N1CCC[C@H]1c1nc(-c2cccnc2)no1>>c1cncc(-c2noc([C@@H]3CCCN3)n2)c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20040236114A1,C[C@H](OCc1ccccc1)[C@@H](CCO)n1cnc(C(N)=O)c1.Oc1ccc(Cl)c(Cl)c1>>C[C@H](OCc1ccccc1)[C@@H](CCOc1ccc(Cl)c(Cl)c1)n1cnc(C(N)=O)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100035883A1,CCOC(=O)c1cccc2c1C(=O)C(c1ccc(C(F)(F)F)cc1)C(c1ccc(CN(C)C)cc1)N2.NN>>CN(C)Cc1ccc(C2Nc3cccc4c(=O)[nH]nc(c34)C2c2ccc(C(F)(F)F)cc2)cc1,,CO,,O,,val
US04070481,CCCCCCCCCCCCC(C(=O)Cc1ccccc1C)C(=O)OCC.O=S(=O)(O)O>>CCCCCCCCCCCCC1=C(O)C(=O)c2c(C)cccc2C1=O,,CCO,,[Na+].[OH-],,val
US05705652,ClCCCl.O=S(=O)(Cl)Cl.S=C=NC=CCCl>>Cl.ClCc1cnc(Cl)s1,,ClCCCl,,,,val
US20100076027A1,NC1CCCCC1.O=C(O)C(c1c2cc(F)c(F)cc2nn1-c1ccc(Cl)cc1)C1CCCCC1>>O=C(NC1CCCCC1)C(c1c2cc(F)c(F)cc2nn1-c1ccc(Cl)cc1)C1CCCCC1,CN(C)c1ccncc1,,,O=S(Cl)Cl,,val
US20100331287A1,COCCCn1ncc2ccc(C(=O)OC)cc21>>COCCCn1ncc2ccc(CO)cc21,,CO,,[BH4-].[Na+],,val
US06498166B1,CS(=O)(=O)c1ccc(B(O)O)cc1.N#Cc1ccc2c(Br)c(-c3ccc(F)cc3)nn2c1>>CS(=O)(=O)c1ccc(-c2c(-c3ccc(F)cc3)nn3cc(C#N)ccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20130336920A1,CN(CC=O)C(=O)OCc1ccccc1.COCCNCCOCCOCCOCCOCCOCCOCCOC>>COCCOCCOCCOCCOCCOCCOCCN(CCOC)CCN(C)C(=O)OCc1ccccc1,,C1CCOC1,CCOC(C)=O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20080275127A1,CCOC(C)(C)ONC(=O)CN(Cc1ccc(OC)cc1)S(=O)(=O)c1ccc(OCCCCF)cc1>>COc1ccc(CN(CC(=O)NO)S(=O)(=O)c2ccc(OCCCCF)cc2)cc1,,CCOC(C)=O,,Cl,,val
US20090198063A1,Cc1ccc(S(=O)(=O)Cl)cc1.[O-][n+]1cccc2ncc(Br)cc21>>O=c1ccc2ncc(Br)cc2[nH]1,,ClC(Cl)Cl,,O,O=C([O-])[O-].[K+].[K+],val
US20050090498A1,CC(=O)c1ccc(Cl)c([N+](=O)[O-])c1.CCOC(=O)Cc1ccc2ccccc2n1>>CC(=O)c1ccc2c(c1)N(O)C(=O)C2=C1C=Cc2ccccc2N1,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20040122046A1,CCn1c2ccccc2c2cc(C=O)ccc21.Nc1ccncc1N>>CCn1c2ccccc2c2cc(-c3nc4cnccc4[nH]3)ccc21,,O=[N+]([O-])c1ccccc1,,,,val
US20130023566A1,CC(C)=NO.CCOC(OCC)c1ccccc1C(=O)c1ccc(Br)cc1F>>CCOC(OCC)c1ccccc1C(=O)c1ccc(Br)cc1ON=C(C)C,,C1CCOC1,O,CC(C)(C)[O-].[K+],,val
US04423047,Clc1cnc(SCI)nc1.Oc1ccc(Cl)cc1>>Clc1ccc(OCSc2ncc(Cl)cn2)cc1,,CCO,,C,C[O-].[Na+],val
US20090247526A1,CC(C)(C)OC(=O)N1CCc2ncnc(Sc3cc(Nc4nc(CCc5ccccc5)cs4)ncc3Br)c2C1>>Brc1cnc(Nc2nc(CCc3ccccc3)cs2)cc1Sc1ncnc2c1CNCC2,,O=C(O)C(F)(F)F,,O=C([O-])O.[Na+],,val
US20040097550A1,Nc1ccc(N2CCCCC2=O)cc1.O=C(Cl)OC(Cl)(Cl)Cl>>O=C=Nc1ccc(N2CCCCC2=O)cc1,,C1CCOC1,,,,val
US20120295981A1,CCOC(=O)Cc1cc(Cl)c(OCC2CC2)c(Br)c1.OB(O)c1ccc(C(F)(F)F)cc1>>CCOC(=O)Cc1cc(Cl)c(OCC2CC2)c(-c2ccc(C(F)(F)F)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150011543A1,CI.Fc1ccc(-c2nn[nH]n2)cc1>>Cn1nnc(-c2ccc(F)cc2)n1,,CC#N,,N#N,O=C([O-])[O-].[K+].[K+],val
US20110046088A1,CCN.COC=Nc1cc(Br)c(OCCCC(C)C)nc1C>>CCN=CNc1cc(Br)c(OCCCC(C)C)nc1C,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US04066651,CC(C(=O)O)c1cc(=O)[nH]c2ccccc12.O=[N+]([O-])O>>CC(C(=O)O)c1cc(=O)[nH]c2ccc([N+](=O)[O-])cc12,,O,,,,val
US05753679,O=C(Cl)c1ccccc1.O=[N+]([O-])c1ccccc1CN1CCC(O)CC1>>O=C(OC1CCN(Cc2ccccc2[N+](=O)[O-])CC1)c1ccccc1,,Cc1ccccc1,,CCN(CC)CC,,val
US06355631B1,O=[SH](=O)N(Cc1cccc(Cl)n1)C1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1.O=[SH](=O)NCc1cccc(Cl)n1.OC1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1>>CS(=O)(=O)N(c1cccc(Cl)n1)C1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130331419A1,C#CC(CC(F)(F)F)(c1ccc(Cl)cc1)n1ncc2c(NC(=O)OC(C)(C)C)cccc21>>CCC(CC(F)(F)F)(c1ccc(Cl)cc1)n1ncc2c(NC(=O)OC(C)(C)C)cccc21,O=[Pt]=O,CCO,,,,val
US20150274777A1,CC(C)(C)OC(=O)N[C@@H](CCc1ccccc1)C(=O)O.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)N[C@@H](CCc1ccccc1)C(=O)OCc1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US04255575,COC(=O)c1cc(C(=O)CBr)ccc1OC.Cl.c1ccc(N2CCNCC2)cc1>>COc1ccc(C(=O)CN2CCN(c3ccccc3)CC2)cc1C(=O)O.Cl,,C1CCOC1,CCOCC,CCN(CC)CC,,val
US05270313,COc1ccccc1Cc1c(NS(=O)(=O)c2ccc(C=O)cc2)ncnc1OCCOC1CCCCO1>>COc1ccccc1Cc1c(NS(=O)(=O)c2ccc(CO)cc2)ncnc1OCCOC1CCCCO1,,CO,,[BH4-].[Na+],,val
US20150148340A1,CCOC(=O)c1cn(-c2ccc3c(c2)C(C)(C)C(=O)N3C)c(=O)[nH]c1=O.FC(F)(F)c1c(Cl)cccc1CBr>>CCOC(=O)c1cn(-c2ccc3c(c2)C(C)(C)C(=O)N3C)c(=O)n(Cc2cccc(Cl)c2C(F)(F)F)c1=O,,O,,,,val
US20130143862A1,CC(=O)NC(=N)N.CC(C)(CNc1ccc(C(=O)CBr)nn1)c1ccc(F)cc1>>CC(=O)Nc1nc(-c2ccc(NCC(C)(C)c3ccc(F)cc3)nn2)c[nH]1,,CC#N,,,,val
US03976771,CC(C)(NC(=O)CCl)c1ccccc1.N>>CC(C)(NC(=O)CN)c1ccccc1,,CCO,,,,val
US06008247,CC(=O)c1ccc(C#N)cc1.N#Cc1ccc(C=O)cc1>>N#Cc1ccc(C=CC(=O)c2ccc(C#N)cc2)cc1,,CO,,,,val
US20120245144A1,Cc1nc(-c2cn3c(n2)-c2cc(S(=O)C4CCN(C(C)(C)CO)CC4)c(F)cc2OCC3)n(C(C)C)n1.O=C(OO)c1cccc(Cl)c1>>Cc1nc(-c2cn3c(n2)-c2cc(S(=O)(=O)C4CCN(C(C)(C)CO)CC4)c(F)cc2OCC3)n(C(C)C)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150210705A1,CC(C)Oc1ccnc2[nH]cc(I)c12.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)n2cc(I)c3c(OC(C)C)ccnc32)cc1,,C1CCOC1,,[H-].[Na+],,val
US20050215577A1,COC(=O)C(C)(C1Cc2c(n(C(=O)OC(C)(C)C)c3ccc(Cl)cc23)C1)S(=O)(=O)c1ccccc1>>CC(C)(C)OC(=O)n1c2c(c3cc(Cl)ccc31)CC(C(C)(CO)S(=O)(=O)c1ccccc1)C2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130143863A1,Brc1cncc(I)c1.CC(=O)N1CC=CC1>>CC(=O)N1CCC(c2cncc(Br)c2)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,CCN(CC)CC,O=CO,val
US20030105074A1,F.O=C(OCc1ccccc1)N1CCC2(CC1)CO2>>O=C(OCc1ccccc1)N1CCC(F)(CO)CC1,,ClCCl,,c1ccncc1,O=C([O-])O.[Na+],val
US20130029980A1,COc1cccc(CCCn2c3nc(=O)[nH]c(=O)c-3nc3cc(C)c(C)cc32)c1>>Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCCc3cccc(O)c3)c2cc1C,,CS(C)=O,ClCCl,BrB(Br)Br,O,val
US04554350,CON=C(C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(c3cnc(-c4cccnc4)s3)CSC12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(c3cnc(-c4cccnc4)s3)CSC12)c1csc(N)n1,,O=CO,,COc1ccccc1,,val
US20060199960A1,CCOC(=O)c1nc(C)ccc1Br.Cn1cc(N)cn1>>CCOC(=O)c1nc(C)ccc1Nc1cnn(C)c1,[Pd],,,,,val
US20070142362A1,CON(C)C(=O)C(C)(C)CC(F)(F)F.Cl[Mg]Cc1ccccc1>>CC(C)(CC(F)(F)F)C(=O)Cc1ccccc1,,C1CCOC1,,,,val
US20160083366A1,CI.O=c1[nH]c(Br)cnc1Cl>>Cn1c(Br)cnc(Cl)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080045556A1,CC(C)(CO)Nc1nc(-c2ccc(C#N)cc2)cs1.O=C(Cl)C(=O)Cl>>CC(C)(C=O)Nc1nc(-c2ccc(C#N)cc2)c(Cl)s1,,C1CCOC1,ClCCl,CCN(CC)CC,CS(C)=O,val
US08895313B2,COc1ccc2nc(-c3ccc(N)cc3)sc2c1.O=C(O)c1ccc(OCCCC(F)(F)F)cc1>>COc1ccc2nc(-c3ccc(NC(=O)c4ccc(OCCCC(F)(F)F)cc4)cc3)sc2c1,,ClC(Cl)Cl,c1ccncc1,O=S(Cl)Cl,,val
US20020099212A1,CCc1ccc(C(=O)O)cc1[N+](=O)[O-]>>CCc1ccc(C(=O)O)cc1N,[Pd],CO,,,,val
US20140010783A1,CS/C(=N\C#N)Nc1ccc(C#N)c(C2CC2)c1.NN>>N#Cc1ccc(Nc2n[nH]c(N)n2)cc1C1CC1,,CCO,,,,val
US04200758,C#CCN1CC(=O)N(C(O)C#N)C1=O.CC(C)C(Nc1ccc(C(F)(F)F)cc1F)C(=O)O>>C#CCN1CC(=O)N(C(C#N)OC(=O)C(Nc2ccc(C(F)(F)F)cc2F)C(C)C)C1=O,,CCOCC,,CCN(CC)CC,,val
US20090247561A1,CN(C)C1(c2ccccc2)CCC(=O)CC1.O=C1c2ccccc2C(=O)N1CBr>>CN(C)C1(c2ccccc2)CCC(=O)C(CN2C(=O)c3ccccc3C2=O)C1,,C1CCOC1,,,,val
US20020008229A1,O=C1NC(=O)c2ccccc21.O=[N+]([O-])c1ccc(CCl)cc1>>O=C1c2ccccc2C(=O)N1Cc1ccc([N+](=O)[O-])cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070082912A1,CC(=O)CCC(=O)c1cc(Cl)ccc1OCc1c(F)cccc1F.Nc1ccc(F)c(C(=O)O)c1>>Cc1ccc(-c2cc(Cl)ccc2OCc2c(F)cccc2F)n1-c1ccc(F)c(C(=O)O)c1,,CC#N,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090291079A1,C1CNCCN1.O=C(Nc1ccc(C(=O)O)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1>>O=C(Nc1ccc(C(=O)N2CCNCC2)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06228872B1,CCN(C(C)C)C(C)C.Cc1ccc(S(=O)(=O)Cl)cc1.OCCCc1cccnc1>>Cc1ccc(S(=O)(=O)[O-])cc1.[NH3+]CCCc1cccnc1,,ClCCl,,,,val
US20060030595A1,N#Cc1cccc(C(=O)c2ccnc(Cl)n2)c1>>N#Cc1cccc(C(O)c2ccnc(Cl)n2)c1,,CO,ClCCl,[BH4-].[Na+],,val
US05039805,CC(=O)O.CC(C)(C)OC(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)Nc1cccc(C(=O)NCCC(=O)OCc2ccccc2)c1>>CC(=O)O.CC(C)(C)OC(=O)N[C@@H](CCCN)C(=O)Nc1cccc(C(=O)NCCC(=O)O)c1,[Pd],CC(=O)O,,CCO,,val
US20120053173A1,CON(C)C(=O)c1oc2cc(F)ccc2c1C>>Cc1c(C=O)oc2cc(F)ccc12,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20130217668A1,C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)[C@@H]1CC[C@H](Nc2cc(OCCN3CCCCC3)ncc2[N+](=O)[O-])CC1>>C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)[C@H]1CC[C@@H](Nc2cc(OCCN3CCCCC3)ncc2N)CC1,,CCOC(C)=O,CO,Cl[Sn]Cl,,val
US20070191333A1,CC(C)(C)OC(=O)NC[C@H]1CCN(Cc2ccccc2)C1>>CC(C)(C)OC(=O)NCC1CCNC1,[Pd],,,,,val
US20040259907A1,CC(O)CN.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)oc21>>CC(O)CNCc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2o1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US05403930,COC(=O)c1cc(C#Cc2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O>>O=C(O)c1cc(C#Cc2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O,,[Na+],[OH-],Cl,,val
US05393758,CC1(N)CNC1.O=C(O)c1cn(C2CC2)c2nc(Cl)c(F)cc2c1=O>>CC1(N)CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C1,,c1ccncc1,,CCN(CC)CC,Cl,val
US20150018342A1,CC[C@@H](NC(=O)c1ccn2c1COCC2)c1ccccc1.O=C(Cl)C(Cl)(Cl)Cl>>CC[C@@H](NC(=O)c1cc(C(=O)C(Cl)(Cl)Cl)n2c1COCC2)c1ccccc1,,ClCCl,,,,val
US20090118283A1,NCC(=O)c1ccc(Br)cc1.O=C(Cl)OCc1ccccc1>>O=C(NCC(=O)c1ccc(Br)cc1)OCc1ccccc1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20060014777A1,CCCc1cc(Cl)c2c(c1)C(O)OC2=O.CCI>>CCCc1cc(Cl)c(C(=O)OCC)c(C=O)c1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20090054405A1,COCCOCCl.Oc1cc(Br)cnc1Cl>>COCCOCOc1cc(Br)cnc1Cl,,CO,,CCN(CC)CC,ClCCCl,val
US06277987B1,CC(C)(C)OC(=O)[C@H](N)CCCN1C(=O)c2ccccc2C1=O.O=S(=O)(Cl)c1ccc(-c2ccc(Cl)cc2)cc1>>CC(C)(C)OC(=O)[C@@H](CCCN1C(=O)c2ccccc2C1=O)NS(=O)(=O)c1ccc(-c2ccc(Cl)cc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20070185143A1,CCOC(=O)c1nn(C)c2c1C(C)(C)CC(=CN(C)C)C2=O.CN1CCN(c2ccc(NC(=N)N)cc2Cl)CC1>>CCOC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)c(Cl)c3)nc1-2,,CN(C)C=O,O,,,val
US20030158082A1,CCOC(=O)C(=O)C(=O)OCC.NOCc1ccccc1>>CCOC(=O)C(=NOCc1ccccc1)C(=O)OCC,,c1ccncc1,,,,val
US20120252815A1,CC(C)(C)[Si](C)(C)OCC=O.CC1(C)CCC(C)(C)c2cc(-c3csc(N4CCN(C5CCNCC5)CC4)n3)ccc21>>CC1(C)CCC(C)(C)c2cc(-c3csc(N4CCN(C5CCN(CCO)CC5)CC4)n3)ccc21,,C1COCCO1,,Cl,,val
US20120258946A1,C=C(C(=O)OCc1ccccc1)c1ccc(COCCOC)c(F)c1>>COCCOCc1ccc(C(C)C(=O)O)cc1F,[Pd],CO,,,,val
US20060100194A1,Brc1ccccc1.O=C1CCC(=O)c2ccc(Cl)cc2N1>>O=C1CCC(=O)N(c2ccccc2)c2cc(Cl)ccc21,[Cu]I,Cc1ccccc1,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US20090042841A1,Cc1cccc(C#CC=C2CCNCC2)n1.O=[N+]([O-])c1cn([N+](=O)[O-])cn1>>Cc1cccc(C#CC=C2CCN(c3[nH]cnc3[N+](=O)[O-])CC2)n1,,CC(C)=O,O,O=C([O-])O.[Na+],,val
US20160083370A1,Cc1ccc(S(=O)(=O)OCCCc2c[nH]c3ccc(F)cc23)cc1.FC(F)(F)c1ccnc(N2CCNCC2)n1>>Fc1ccc2[nH]cc(CCCN3CCN(c4nccc(C(F)(F)F)n4)CC3)c2c1,,CC#N,,[I-].[K+],,val
US20040067968A1,Cn1c(=O)cc(C(N)=O)c2cc(C(=O)c3ccc(Cl)cc3)ccc21>>Cn1c(=O)cc(C#N)c2cc(C(=O)c3ccc(Cl)cc3)ccc21,,O=P(Cl)(Cl)Cl,,,,val
US20120040942A1,CC(C)(C)c1ccc(CN)cc1.CC1=CC(=O)OC(C)(C)O1>>CC(=O)CC(=O)NCc1ccc(C(C)(C)C)cc1,,CCOC(C)=O,Cc1ccccc1,,,val
US20070244159A1,CC(C)(C)Br.O=[N+]([O-])c1ccc2[nH]ccc2c1>>CC(C)(C)c1c[nH]c2ccc([N+](=O)[O-])cc12,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20070208024A1,Brc1ccc(CC2CC2)cc1.COC(=O)c1ccc(B(O)O)cc1>>COC(=O)c1ccc(-c2ccc(C(=O)C3CC3)cc2)cc1,,CCO,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20090149475A1,CCOC(=O)CC#N.NC(=S)NCc1ccncc1>>Nc1cc(=O)[nH]c(=S)n1Cc1ccncc1,,CC(=O)O,,,,val
US20090264406A1,Cn1cc(-c2ccc3ncc(Cc4ccc5ncc(Br)n5c4)n3n2)cn1.OB(O)c1cccnc1>>Cn1cc(-c2ccc3ncc(Cc4ccc5ncc(-c6cccnc6)n5c4)n3n2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20060084663A1,CCCc1cc(O)ccc1OCC(=O)OCC.Cc1nc(-c2ccc(C(F)(F)F)cc2)oc1CCl>>CCCc1cc(OCc2oc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1OCC(=O)OC,,CC#N,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20160145297A1,CC(C)(C)OC(=O)N1[C@@H](Cc2ccccc2)C(CCC#N)OC1(C)C.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CC(C)(C)OC(=O)N1[C@@H](Cc2ccccc2)[C@H](CCC(=O)O)OC1(C)C,,CO,,[K+].[OH-],,val
US20020099215A1,O=C(NC(CCCc1ccccc1)CCCc1ccccc1)C1CCN(C(=O)C2CCNCC2)CC1.c1cc(OC[C@H]2CO2)c2cccnc2c1>>O=C(NC(CCCc1ccccc1)CCCc1ccccc1)C1CCN(C(=O)C2CCN(C[C@@H](O)COc3cccc4ncccc34)CC2)CC1,,CCO,,,,val
US20150259367A1,N.O=C1Nc2ccccc2C12CC(=NO)C2>>NN1C(=O)C2(CCC2)c2ccccc21,[Ni],CO,,,,val
US20100173909A1,C=CCO[C@H]1CNCC[C@H]1NC(=O)c1[nH]c(C)c(Cl)c1Cl.COC(=O)c1sc(Cl)nc1-c1ncnn1C>>C=CCO[C@H]1CN(c2nc(-c3ncnn3C)c(C(=O)OC)s2)CC[C@H]1NC(=O)c1[nH]c(C)c(Cl)c1Cl,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,O,val
US04785010,CC(=O)CCC(=O)CN1C(=O)c2ccccc2C1=O.Cl.NCCCn1ccnc1>>Cc1ccc(CN2C(=O)c3ccccc3C2=O)n1CCCn1ccnc1.Cl,,CC(=O)O,,,,val
US20070185195A1,CCc1oc2cc(OC)ccc2c1C(=O)c1ccc(OC)cc1>>CCc1oc2cc(OC)ccc2c1C(=O)c1ccc(O)cc1,,CN(C)C=O,,[Na],,val
US20110034521A1,Nc1cc(-c2ccc(Cl)cc2)nn1Cc1ccccc1.O=C(O)CS>>O=C(CS)Nc1cc(-c2ccc(Cl)cc2)nn1Cc1ccccc1,,Cc1ccccc1,,,,val
US20100076014A1,CC=C(OC)O[Si](C)(C)C.OC(c1ccccc1)c1ccc2[nH]ncc2c1>>COC(=O)C(C)C(c1ccccc1)c1ccc2[nH]ncc2c1,Cl[Ti](Cl)(Cl)Cl,CC#N,,ClCCl,,val
US20160145204A1,CCC=Cc1cccc(C)c1.CCCCCCC=CCCCCCC>>CCCCCCC=CCCc1ccccc1C,,ClCCl,,,,val
US20100286116A1,CCOC(=O)c1cnc(Cl)s1.Cc1onc(-c2ccccc2)c1CO>>CCOC(=O)c1cnc(OCc2c(-c3ccccc3)noc2C)s1,,C1CCOC1,C1CCOC1,O,[H-].[Na+],val
US20070287696A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.CCOC(=O)CN>>CCOC(=O)CNC1CCN(C(=O)OC(C)(C)C)CC1,,CO,,Cl,[BH3-]C#N.[Na+],val
US20060030583A1,CN(C)C(=O)c1cc(Br)ccc1N.COc1ccccc1-c1cn(S(=O)(=O)c2ccc(C)cc2)c2ncc(B3OC(C)(C)C(C)(C)O3)cc12>>COc1ccccc1-c1c[nH]c2ncc(-c3ccc(N)c(C(=O)N(C)C)c3)cc12,,CC#N,,O=C([O-])O.[Na+],,val
US20040121965A1,CC(=O)NCC(=O)O.Cc1cccc(C=O)c1>>CC1=N/C(=C\c2cccc(C)c2)C(=O)O1,,CC(=O)OC(C)=O,,CC(=O)[O-].[Na+],,val
US20080171772A1,CCOC(=O)c1ccc(C#CC(C)C)c(N)c1>>CCOC(=O)c1ccc2cc(C(C)C)[nH]c2c1,[Cu]I,CN(C)C=O,,,,val
US20070249639A1,CC(C)(C)N.Clc1nc(Cl)c2ncn(C3CCCCO3)c2n1>>CC(C)(C)Nc1nc(Cl)nc2c1ncn2C1CCCCO1,,CCO,,O=C([O-])O.[Na+],,val
US20070219370A1,COC(OC)N(C)C.NC(=S)NC(c1ccccc1)(c1ccccc1)c1ccccc1>>CN(C)C=NC(=S)NC(c1ccccc1)(c1ccccc1)c1ccccc1,,CO,,,,val
US20150164074A1,C=C(OCC)c1nc(C(=O)OC)c(Cl)c(N)c1F>>COC(=O)c1nc(C(C)=O)c(F)c(N)c1Cl,,C1CCOC1,,Cl,,val
US20110257137A1,CCOC=CC(=O)Cl.Nc1cccc(Cl)c1>>CCOC=CC(=O)Nc1cccc(Cl)c1,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US04046907,CSC(=C[N+](=O)[O-])NCCSCc1[nH]cnc1C.NCCSCc1nccs1>>Cc1nc[nH]c1CSCCNC(=C[N+](=O)[O-])NCCSCc1nccs1,,CC#N,,,,val
US20080096877A1,COCCOc1cc(N(C)S(=O)(=O)c2ccccn2)c2[nH]c(C(=O)NCC(C)(SCc3ccccc3)C(OC)OC)cc2c1>>COCCOc1cc(N(C)S(=O)(=O)c2ccccn2)c2[nH]c(C(=O)NCC(C)(C=O)SCc3ccccc3)cc2c1,,CC(C)=O,,O,,val
US05506256,BrCCCCCBr.CC(C)(C)OC(=O)[C@@H](N)Cc1ccccc1>>CC(C)(C)OC(=O)[C@H](Cc1ccccc1)N1CCCCC1,,CCOCC,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20130303509A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(NC(=O)C3CN(c4cccnc4)C3)cc2)CC1>>O=C(Nc1ccc(OC2CCNCC2)cc1)C1CN(c2cccnc2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110098297A1,CS(=O)(=O)c1ccc(Br)nc1.O=[N+]([O-])c1ccc(O)cc1OCc1ccccc1>>CS(=O)(=O)c1ccc(Oc2ccc([N+](=O)[O-])c(OCc3ccccc3)c2)nc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060257987A1,COC(=O)CCc1ccc(OCC[C@H](C)Oc2ncc(C(F)(F)F)cc2-c2cccnc2)cc1C>>Cc1cc(OCC[C@H](C)Oc2ncc(C(F)(F)F)cc2-c2cccnc2)ccc1CCC(=O)O,,CO,,Cl,[Na+].[OH-],val
US20130267521A1,C[C@H](NC(=O)c1cccnc1Br)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1.OB(O)c1cn[nH]c1>>C[C@H](NC(=O)c1cccnc1-c1cn[nH]c1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20130045169A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O.ClCCCC1OCCO1>>N[C@@H](Cc1ccccc1)C(=O)OCCCC1OCCO1,,C1COCCO1,,Cl,,val
US05204344,COC(=O)C(C)(C)CC(=O)CSC(C)(C)C.COc1ccc(NN)cc1>>COC(=O)C(C)(C)Cc1[nH]c2ccc(OC)cc2c1SC(C)(C)C,,CC(C)(C)O,,Cl,,val
US20070287725A1,C#CCNc1c(NC(=O)COCC)c(Cl)nc2ccccc12>>C#CCn1c(COCC)nc2c(Cl)nc3ccccc3c21,,CCO,,CCN(CC)CC,,val
US20120065233A1,Cc1ccc(F)cc1C[C@@H](C)OS(C)(=O)=O.[N-]=[N+]=[N-]>>Cc1ccc(F)cc1C[C@H](C)N=[N+]=[N-],,CN(C)C=O,,O,,val
US20040102479A1,COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2CCCCCCCCCN)cc1.O=S(=O)(Cl)CCCC(F)(F)C(F)(F)F>>CC1(c2ccc(O)cc2)COc2cc(O)ccc2C1CCCCCCCCCNS(=O)(=O)CCCC(F)(F)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20160272592A1,C=Cc1ccc(COC)cc1Br.O=C(Cl)C(Cl)(Cl)Cl>>COCc1ccc(C2CC(=O)C2(Cl)Cl)c(Br)c1,[Zn],CCOCC,,O=P(Cl)(Cl)Cl,,val
US20040102450A1,C[C@H]1CN(Cc2ccc3c(N)ncnc3c2)C(=O)[C@H](C)N1.O=C(O)C=Cc1ccc(Cl)s1>>C[C@H]1CN(Cc2ccc3c(N)ncnc3c2)C(=O)[C@H](C)N1C(=O)C=Cc1ccc(Cl)s1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20140045966A1,O=c1c2ccccc2sc2ccc(Cl)cc12.Sc1ccccc1>>O=c1c2ccccc2sc2ccc(Sc3ccccc3)cc12,,CN(C)C=O,,[K+].[OH-],,val
US20100234485A1,CC(=O)C(C)C.CCOC(=O)c1ccccc1C(=O)c1ccccc1>>CC(C)C(=O)CC(=O)c1ccc(C(=O)c2ccccc2)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US04271152,CC(C)(C)OC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)O.CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCNC(=O)OC(C)(C)C)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)OC(C)(C)C)[C@@H](C)O)C(C)C>>CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)OC(C)(C)C)[C@@H](C)O)C(C)C,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20130310384A1,CCC(CC)NS(=O)(=O)c1ccc(F)cc1.COC(=O)c1ccc(CBr)nc1>>CCC(CC)N(Cc1ccc(C(=O)OC)cn1)S(=O)(=O)c1ccc(F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05834471,CCOC(=O)N1CCNCC1.CCOC(=O)c1ccc(F)cc1>>CCOC(=O)c1ccc(N2CCN(C(=O)OCC)CC2)cc1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090324543A1,CC1(C)OB(c2ccc(C(=O)O)s2)OC1(C)C.NC1CC1>>CC1(C)OB(c2ccc(C(=O)NC3CC3)s2)OC1(C)C,,CC#N,CN(C)C=O,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US05166204,COc1ccc2[nH]c3c(C)cc4c(c3c2c1)C(=O)N(CCNC(C)=O)C4=O.Cl>>COc1ccc2[nH]c3c(C)cc4c(c3c2c1)C(=O)N(CCN)C4=O.Cl,,CCO,,,,val
US20080293718A1,CN1C(=O)C(c2ccccc2)(c2cccc(O)c2)NC1=S.CS(=O)(=O)Cl>>CN1C(=O)C(c2ccccc2)(c2cccc(OS(C)(=O)=O)c2)NC1=S,,ClCCl,,CCN(CC)CC,,val
US06352993B1,COc1ccc(OC)c2c1CCN(c1nc(Cl)nc(C)c1C)C2C.Nc1ccc(F)cc1>>COc1ccc(OC)c2c1CCN(c1nc(Nc3ccc(F)cc3)nc(C)c1C)C2C.Cl,,CN(C)C=O,,CCN(CC)CC,,val
US20130172312A1,CC(C)(C)OC(=O)N1CC(OS(C)(=O)=O)C1.Oc1ccc(OCC2CC2)cc1>>CC(C)(C)OC(=O)N1CC(Oc2ccc(OCC3CC3)cc2)C1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05541343,N=C(N)c1ccc2c(c1)C(=O)c1cc(OC[C@@H]3C[C@@H](CC(=O)O)C(=O)N3CCCc3ccccc3)ccc1-2>>N=C(N)c1ccc2c(c1)Cc1cc(OC[C@@H]3C[C@@H](CC(=O)O)C(=O)N3CCCc3ccccc3)ccc1-2,[Pd],CC(=O)O,,[H][H],,val
US20010056100A1,COC(=O)C(Cc1ccccc1)NC(=O)OCc1ccc(COc2ccc(F)cc2)cc1>>O=C(NC(Cc1ccccc1)C(=O)O)OCc1ccc(COc2ccc(F)cc2)cc1,,CO,O,Cl,[Li+].[OH-],val
US20080146606A1,Cc1ccc(S(=O)(=O)n2c(C#CCO)cc3c(-c4ccc(S(=O)(=O)NCCN(C(=O)[O-])C(C)(C)C)cc4)ccnc32)cc1>>NCCNS(=O)(=O)c1ccc(-c2ccnc3[nH]c(C#CCO)cc23)cc1.O=CO,,ClC(Cl)Cl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070111988A1,CC1(C)OB(c2ccc3c(c2)CNC3=O)OC1(C)C.COc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(Br)sc2c1>>COc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3ccc4c(c3)CNC4=O)sc2c1,,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20130150342A1,CCOC(=O)Cl.CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1C1CCCC1>>CCOC(=O)N1C2CCC1CN(C(=O)c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc1)C2,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US20080255143A1,CC(C)(C)CCN.CCOC(=O)c1cnc(Cl)c([N+](=O)[O-])c1Cl>>CCOC(=O)c1cnc(Cl)c([N+](=O)[O-])c1NCCC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20090054508A1,Nc1ccccc1/C=C/c1n[nH]c2ccccc12.O=C(N=C=S)c1ccccc1>>NC(=S)Nc1ccccc1/C=C/c1n[nH]c2ccccc12,,CC(C)=O,,O,,val
US20150018343A1,Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1CO[C@H]1CCCN(C(=O)OC(C)(C)C)C1)C3>>Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1CO[C@H]1CCCNC1)C3,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040220233A1,Cc1ccc(C(=O)NC2CC2)cc1N.O=C(Cl)CCl>>Cc1ccc(C(=O)NC2CC2)cc1NC(=O)CCl,,CC(C)=O,,CN1CCOCC1,Cl,val
US20140107100A1,CNC.Cc1nc(CCl)nc(O)c1C(C)C.O=P(Cl)(Cl)Cl>>Cc1nc(CN(C)C)nc(Cl)c1C(C)C,,CCOC(C)=O,CO,C1CCOC1,,val
US20090062360A1,N#Cc1ccc(C2=NC3(CCCC3)NC2=O)cc1.O=C(CBr)Nc1cc(F)cc(F)c1>>N#Cc1ccc(C2=NC3(CCCC3)N(CC(=O)Nc3cc(F)cc(F)c3)C2=O)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20140228396A1,Cc1ccc(N)nc1.N#Cc1cncc(Br)c1>>Cc1ccc(NC(=N)c2cncc(Br)c2)nc1,,C1CCOC1,,[Li]CCCC,,val
US05658908,C=CCBr.C[C@@H]1CN(C(c2ccc(Br)cc2)c2cccc(O[Si](C)(C)C(C)(C)C)c2)[C@@H](C)CN1>>C=CCN1C[C@@H](C)N(C(c2ccc(Br)cc2)c2cccc(O[Si](C)(C)C(C)(C)C)c2)C[C@@H]1C,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20090156615A1,Cc1cc(-n2ccc(O)cc2=O)sc1C(=O)NCc1ccccc1.Cc1ccc(S(=O)(=O)OCCC2CC2)cc1>>Cc1cc(-n2ccc(OCCC3CC3)cc2=O)sc1C(=O)NCc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070003539A1,CS(=O)(=O)c1ccccc1C#N.Cl>>CS(=O)(=O)c1ccccc1CN.Cl,[Pd],CO,,C1COCCO1,,val
US20070213331A1,COc1ccccc1O[C@@H]1C[C@H]([C@H]2OC(C)(C)N(C(C)=O)[C@H]2Cc2cc(F)cc(F)c2)N(C(=O)OC(C)(C)C)C1.Cl>>COc1ccccc1O[C@H]1CN[C@@H]([C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(C)=O)C1.Cl,,C1COCCO1,,,,val
US20080318923A1,COc1ccc(C=O)cc1Br.OCCO>>COc1ccc(C2OCCO2)cc1Br,,O,c1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20150119412A1,COC(=O)c1ccc(C2CC2)cc1OC(C)C.O=c1[nH]c(=O)n(Br)c(=O)n1Br>>COC(=O)c1cc(Br)c(C2CC2)cc1OC(C)C,,CN(C)C=O,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20110052534A1,CC(C)O.CCCOc1ccc(-c2ccc(C(C(=O)OC)n3cc4nc(-c5cccc(F)c5F)nc-4cn3)cn2)c(C(F)(F)F)c1>>CCCOc1ccc(-c2ccc(C(C(=O)OC(C)C)n3cc4nc(-c5cccc(F)c5F)nc-4cn3)cn2)c(C(F)(F)F)c1,,CCOC(C)=O,,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US05708173,CCOC(=O)C=Cc1ccc(NC(=O)OC(C)(C)C)cc1.COCCBr>>CCOC(=O)C=Cc1ccc(N(CCOC)C(=O)OC(C)(C)C)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20100041711A1,CCOC(=O)C(C)(C)CSc1cnc(N)s1.C[C@@H]1CC[C@@H](NCCOCc2ccccc2Cl)CC1.O=C(n1ccnc1)n1ccnc1>>C[C@@H]1CC[C@@H](N(CCOCc2ccccc2Cl)C(=O)Nc2ncc(SCC(C)(C)C(=O)O)s2)CC1,CN(C)c1ccncc1,C1CCOC1,CCO,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20150057271A1,N#Cc1cc(C(F)(F)F)ccc1N1CCOc2cc(S(=O)(=O)Oc3c(F)c(F)c(F)c(F)c3F)ccc21.Nc1ncco1>>N#Cc1cc(C(F)(F)F)ccc1N1CCOc2cc(S(=O)(=O)Nc3ncco3)ccc21,CC(=O)O,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100168082A1,CN(C)C(=O)Cl.Cc1ccc(C)n1-c1ccn(C)n1>>Cc1ccc(C)n1-c1cc(C(=O)N(C)C)n(C)n1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20160264552A1,CNC/C=C/C(=O)Nc1ccc(CN2CCC(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC2)cc1.NC(=O)CCl>>CN(C/C=C/C(=O)Nc1ccc(CN2CCC(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC2)cc1)CC(N)=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US08629147B2,Cc1cc(N2CCCC3(CCCN(Cc4ccccc4)C3)C2)cc2[nH]c(-c3c(I)ccnc3Cl)nc12.O>>Cc1cc(N2CCCC3(CCCN(Cc4ccccc4)C3)C2)cc2[nH]c(-c3c(Cl)cc[nH]c3=O)nc12,,O,,C1COCCO1,Cl,val
US20040186102A1,O=C(C1NCC(c2ccccc2)c2ccccc21)C(F)(F)F>>c1ccc(C2CNCc3ccccc32)cc1,,CO,,O,[K+].[OH-],val
US20110172429A1,CC(C)(C)OC(=O)NN.Cc1ccc(C(=O)Cl)o1>>Cc1ccc(C(=O)NN)o1,,ClCCl,,,,val
US20010027196A1,CSCCCl.N#Cc1c(-c2ccccc2)nc(N)[nH]c1=S>>CSCCSc1nc(N)nc(-c2ccccc2)c1C#N,,CCO,,C,C[O-].[Na+],val
US20060205728A1,COC(=O)c1cccc(C(=O)OC)c1>>COC(=O)c1cccc(C(=O)O)c1,,CC(C)=O,CO,[Na+].[OH-],,val
US20090181967A1,CN1CCO[C@@H](CO)C1.O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCN(c2ccccc2)CC1>>CN1CCO[C@@H](COC(=O)N2CCN(c3ccccc3)CC2)C1,,C1CCOC1,,[H-].[Na+],,val
US06300334B1,CC(C)Cn1c(=O)n(C)c(=O)c2c(OCCCOC3CCCCO3)c(Cc3cccnc3)sc21>>CC(C)Cn1c(=O)n(C)c(=O)c2c(OCCCO)c(Cc3cccnc3)sc21,,CO,,Cc1ccccc1S(=O)(=O)O,,val
US20110319350A1,C=CCC(=O)[C@@H](O)[C@H](O)[C@H](CO)N=[N+]=[N-]>>[N-]=[N+]=N[C@@H](CO)[C@@H](O)[C@H](O)C=O,Cl[Pd]Cl,CO,,O,,val
US20150232435A1,CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.N#Cc1cccc(N2CCNCC2)c1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCN(c4cccc(C#N)c4)CC3)CC2)cc(C(F)(F)F)n1,,CO,ClC(Cl)Cl,,,val
US04855323,C1CCOC1.OCC(O)CSCC(O)Cc1cccc(C2CCCC2)c1OCc1ccccc1>>O=C1OCC(CSCC(O)Cc2cccc(C3CCCC3)c2OCc2ccccc2)O1,,CCOCC,,,,val
US20030130337A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CSc1ccc2cc(C)[nH]c2c1>>CSc1ccc2cc(C)n(C(=O)OC(C)(C)C)c2c1,CN(C)c1ccncc1,CC#N,,,,val
US20110098324A1,CCCCN.CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(Cc2ccc(C)cc2C)c1=O>>CCCCNC(=O)c1c(O)c(C(=O)NCC(=O)O)c(=O)n(Cc2ccc(C)cc2C)c1O,,ClC(Cl)Cl,,,,val
US20090298744A1,CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)Cl)c3)nc2n(CCC)c1=O.FC(F)(F)c1cccc(N2CCNCC2)c1>>CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)c3)nc2n(CCC)c1=O,,C1CCOC1,,,,val
US20140142085A1,CON(C)C(=O)c1ncncc1Br>>O=Cc1ncncc1Br,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US05286650,CCCC(=O)Cl.O=C1CC(=O)/C(=C/c2ccccc2)N1>>CCCC(=O)OC1=CC(=O)N/C1=C\c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20100204226A1,CCOC(=O)c1cnn(-c2nc3cc(I)ccc3c(=O)[nH]2)c1.COCCOCCl>>CCOC(=O)c1cnn(-c2nc3cc(I)ccc3c(=O)n2COCCOC)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20140024650A1,CC(C)(C)OC(=O)NC1CCOCC1CO.Cc1cnn(-c2ccc(O)cc2)c1>>Cc1cnn(-c2ccc(OCC3COCCC3NC(=O)OC(C)(C)C)cc2)c1,,Cc1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US04963590,COc1ccc(C(C)=O)cc1OC.O=Cc1cc(O)c(O)c([N+](=O)[O-])c1>>COc1ccc(C(=O)C=Cc2cc(O)c(O)c([N+](=O)[O-])c2)cc1OC,,CO,,,,val
US20130336920A1,CC(=O)c1cccc(C(F)(F)F)c1.N>>CC(N)c1cccc(C(F)(F)F)c1,,CCO,,[BH4-].[Na+],,val
US20090093454A1,CC(C)(C)OC(=O)NC1CNC1.Fc1cccc2nc(CN3CCC[C@H]4CCc5cccnc5[C@H]43)cn12>>CC(C)(C)OC(=O)NC1CN(c2cccc3nc(CN4CCC[C@H]5CCc6cccnc6[C@H]54)cn23)C1,,CN1CCCC1=O,,O,,val
US20070287838A1,Nc1ccc(Oc2ccnc(N)c2[N+](=O)[O-])cc1.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>Nc1nccc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)c1[N+](=O)[O-],,ClCCl,,,,val
US20080317806A1,C1CSCCN1.O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(C(F)(F)F)c1>>O=[N+]([O-])c1cc([N+](=O)[O-])c(N2CCSCC2)c(C(F)(F)F)c1,,ClCCl,,,,val
US20050272709A1,NCC1=NN=C(N)C1=NNc1ccc(F)c(F)c1.O=C(Cl)c1cccnc1>>NC1=NN=C(CNC(=O)c2cccnc2)C1=NNc1ccc(F)c(F)c1,,CN(C)C=O,,CCN(CC)CC,CCOC(C)=O,val
US20110257151A1,CC1(C)Cc2cc(S(C)(=O)=O)ccc2NC1c1cccc(N)c1.COC(=O)C(C)(C)Br>>COC(=O)C(C)(C)Nc1cccc(C2Nc3ccc(S(C)(=O)=O)cc3CC2(C)C)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090318428A1,O=C(Nc1cnc2[nH]ccc2c1)c1cc([N+](=O)[O-])ccc1Cl>>Nc1ccc(Cl)c(C(=O)Nc2cnc3[nH]ccc3c2)c1,[Pt],C1CCOC1,,,,val
US20080051418A1,CCOC(=O)CCc1cc(OC(C)C)n[nH]1.COc1ccccc1CCl>>CCOC(=O)CCc1cc(OC(C)C)nn1Cc1ccccc1OC,,CN(C)C=O,,Cl,[H-].[Na+],val
US20080305081A1,CCO/C=C\c1nc(SC)ncc1C#N.Cc1cccnc1N>>CSc1ncc(C#N)c(-c2cnc3c(C)cccn23)n1,,C1COCCO1,O,O=C1CCC(=O)N1Br,,val
US20160024021A1,COC(=O)c1cc(/C=C/c2cnc(Nc3ccnc(C)c3)nc2)c(F)c(OC)c1>>COC(=O)c1cc(CCc2cnc(Nc3ccnc(C)c3)nc2)c(F)c(OC)c1,[Pd],C1CCOC1,CO,,,val
US20070275968A1,CC(=O)OC(C)(C)C(=O)Nc1ccc(-c2cccc(-c3nc(C(C)C)[nH]c3-c3cccc(C)n3)c2)cc1>>Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(-c3ccc(NC(=O)C(C)(C)O)cc3)c2)n1,,CO,,[K+].[OH-],,val
US20080027067A1,O=C(N1CCC(c2ccc(S(=O)(=O)Nc3ncns3)cc2)CC1)C(F)(F)F>>O=S(=O)(Nc1ncns1)c1ccc(C2CCNCC2)cc1,,O,,Cl,[Na+].[OH-],val
US20070184018A1,CC(C)N.Cc1cc(C#N)cc2c(=O)oc(-c3cc(Br)nn3-c3ccccc3Cl)nc12>>Cc1cc(C#N)cc(C(=O)NC(C)C)c1NC(=O)c1cc(Br)nn1-c1ccccc1Cl,,CC#N,,,,val
US20080051441A1,C=Cc1ccc(S(N)(=O)=O)cc1.Cc1cc(C)c(C#[N+][O-])c(C)c1>>Cc1cc(C)c(C2=NOC(c3ccc(S(N)(=O)=O)cc3)C2)c(C)c1,,ClC(Cl)Cl,,,,val
US04054579,Cc1ccc2c(c1)CCc1ccccc1C2=O.ClC(Cl)(Cl)Cl>>CCc1ccc2c(c1)CCc1ccccc1C2=O,,ClC(Cl)(Cl)Cl,,O=C1CCC(=O)N1Br,,val
US04673746,COc1cccc(OC)c1C.O=C(Cl)c1ccccc1F>>COc1ccc(C(=O)c2ccccc2F)c(O)c1C,,CC(Cl)Cl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20070082912A1,BrCc1ccc(-c2ccccc2)cc1.CCOC(=O)c1cccc(-n2c(C)ccc2-c2cc(Br)ccc2O)c1>>CCOC(=O)c1cccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(-c3ccccc3)cc2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120010190A1,Cc1cc(/C(C[C@H](c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1.NCCO>>Cc1cc(/C(C[C@H](c2ccc(C(=O)NCCO)cc2)c2ccccc2C)=N/O)ccn1,,C1CCOC1,,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,,val
US04380638,CCN.CN(C)Cc1ccc(CSCCN)o1.COC1=NS(=O)N=C1OC>>CCNC1=NS(=O)N=C1NCCSCc1ccc(CN(C)C)o1,,CO,,,,val
US20050130976A1,CO.O=C(O)c1cc(Br)c(F)c(F)c1Nc1ccccc1Cl>>COC(=O)c1cc(Br)c(F)c(F)c1Nc1ccccc1Cl,,C1CCOC1,CO,C[Si](C)(C)C=[N+]=[N-],,val
US20080039625A1,COC(=O)c1ccc([N+](=O)[O-])c(C=C(Br)Br)c1>>COC(=O)c1ccc(N)c(C=C(Br)Br)c1,[Pt],CO,,,,val
US20140235608A1,COc1c(C(=O)N[C@H](C)c2cccc(Br)c2)ccn(C)c1=O.OB(O)c1ccc(F)cc1>>COc1c(C(=O)N[C@H](C)c2cccc(-c3ccc(F)cc3)c2)ccn(C)c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20060178373A1,COc1cc(-c2cc(=O)c3ccc(OCC4CO4)cc3o2)cc(OC)c1OC.c1ccc(N2CCNCC2)cc1>>COc1cc(-c2oc3ccccc3c(=O)c2OCC(O)CN2CCN(c3ccccc3)CC2)cc(OC)c1OC,,CO,,,,val
US20020032186A1,CCCCOc1ccc(S(=O)(=O)C2(C(=O)OCC)CCN(Cc3ccc(F)cc3)CC2)cc1>>CCCCOc1ccc(S(=O)(=O)C2(C(=O)O)CCN(Cc3ccc(F)cc3)CC2)cc1,,[Na+],[OH-],,,val
US20040082619A1,CCCCI.O=c1[nH]cccc1CO>>CCCCn1cccc(CO)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090270505A1,BrCCCCCCCCCOC1CCCCO1.OCCc1ccccc1>>c1ccc(CCOCCCCCCCCCOC2CCCCO2)cc1,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US04824952,COCC(=O)C1CC(C)CCC1=O.N#CCC(N)=O>>COCc1[nH]c(=O)c(C#N)c2c1CC(C)CC2,,CCO,,C1CCNCC1,,val
US20090221555A1,O=C1CCOc2ccc([N+](=O)[O-])cc2N1>>Nc1ccc2c(c1)NC(=O)CCO2,[Pd],,,CO,,val
US20070093526A1,CC(C)CNC1CCN(C(=O)OC(C)(C)C)CC1.O=Cc1cnc2ccccc2c1>>CC(C)CN(Cc1cnc2ccccc2c1)C1CCN(C(=O)OC(C)(C)C)CC1,,ClCCCl,,CC(=O)O,[Na+].[OH-],val
US20030013720A1,CN1CCC(CNCCN(C(=O)OC(C)(C)C)c2ccc(F)c(F)c2)(c2ccc(I)cc2)CC1>>CN1CCC(CNCCNc2ccc(F)c(F)c2)(c2ccc(I)cc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090209524A1,CCC[C@H](N)CO.COc1cc(CC#N)ccc1Cc1c(C)nc(N)nc1Cl>>CCC[C@@H](CO)Nc1nc(N)nc(C)c1Cc1ccc(CC#N)cc1OC,,CCOC(C)=O,CN1CCCC1=O,,,val
US20100267709A1,CB1OB(C)OB(C)O1.NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c2c1[nH]c1cc(-c3cnc(N)nc3)c(Br)cc12>>Cc1cc2c(cc1-c1cnc(N)nc1)[nH]c1c(C(N)=O)cnc(N[C@H](C3CC3)C(F)(F)F)c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20070293516A1,COc1cc(F)cc(C(=O)O)c1.O=C(Cl)C(=O)Cl>>COc1cc(F)cc(C(=O)Cl)c1,CN(C)C=O,ClCCl,,,,val
US20100056530A1,COC(=O)CCC(=O)CBr.NC(=S)Nc1ncc(Br)cc1OCc1ccccc1>>COC(=O)CCc1csc(Nc2ncc(Br)cc2OCc2ccccc2)n1,,CO,,CCN(CC)CC,,val
US20140134132A1,C[C@H](CO)[C@@H](c1ccco1)N(C)C(=O)OC(C)(C)C.O=C(O)CBr>>C[C@H](COCC(=O)O)[C@@H](c1ccco1)N(C)C(=O)OC(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US05541324,NC(=S)c1ncn2c1CN(C(=O)N1CCOCC1)c1ccccc1-2.O=C(CBr)C1CC1>>O=C(N1CCOCC1)N1Cc2c(-c3nc(C4CC4)cs3)ncn2-c2ccccc21,,CCO,,,,val
US20150368247A1,C[C@@H]1CC[C@@H](Cn2cnc3nc(C(=O)O)nc(N[C@H](C)C4CCC4)c32)CC1.NN>>C[C@@H]1CC[C@@H](Cn2cnc3nc(C(=O)NN)nc(N[C@H](C)C4CCC4)c32)CC1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20140206681A1,COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CNCC(=O)N3C2)n2ccnc(N)c12.O=C(Cl)c1ccncc1>>COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CN(C(=O)c4ccncc4)CC(=O)N3C2)n2ccnc(N)c12,,ClCCl,,CCN(CC)CC,Cl,val
US20150011562A1,CCOc1cc(N2CCN(c3ccccc3C)CC2)c(N)cc1C(=O)NCCCN1CCCC1=O.O=C(O)c1coc(C2CC2)n1>>CCOc1cc(N2CCN(c3ccccc3C)CC2)c(NC(=O)c2coc(C3CC3)n2)cc1C(=O)NCCCN1CCCC1=O,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090318445A1,CCCC[C@H](CC(=O)O)C(=O)N1CCC[C@H]1c1nc2ccccc2o1.N>>CCCC[C@H](CC(N)=O)C(=O)N1CCC[C@H]1c1nc2ccccc2o1,,CO,,,,val
US20030073731A1,CC(=O)OCCc1c([N+](=O)[O-])cc(NC(=O)OC(C)(C)C)c2ccccc12>>CC(=O)OCCc1c(N)cc(NC(=O)OC(C)(C)C)c2ccccc12,[Pd],C1CCOC1,,,,val
US20090112000A1,COCNCCC(=O)c1cccs1>>COCNCCC(O)c1cccs1,,CO,O,Cl,[Na+].[OH-],val
US06291475B1,CCC(C)(C)OC(=O)N1CC2CNCC(C2)C1.N#Cc1ccc(OCC2CO2)cc1>>CCC(C)(C)OC(=O)N1CC2CC(CN(CC(O)COc3ccc(C#N)cc3)C2)C1,,CC(C)O,O,,,val
US20040132727A1,CI.COc1cc2ncnc(Oc3ccc(NC(=O)OC4CCCCC4)cc3)c2cc1OC>>COc1cc2ncnc(Oc3ccc(N(C)C(=O)OC4CCCCC4)cc3)c2cc1OC,,O,,CN(C)C=O,[H-].[Na+],val
US20160015712A1,NC(=O)[C@@H]1CC[C@@H](Nc2ncc3nnn(-c4ccc(-c5cnn(CCOC6CCCCO6)c5)cc4)c3n2)C1>>NC(=O)[C@@H]1CC[C@@H](Nc2ncc3nnn(-c4ccc(-c5cnn(CCO)c5)cc4)c3n2)C1,,C1COCCO1,ClCCl,CO,Cl,val
US20030216432A1,CN(C)C=O.COc1ccc(Br)c(F)c1>>COc1ccc(C=O)c(F)c1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US06153770,CCC(Br)C(C)=O.SCc1ccco1>>CCCC(=O)CSc1ccoc1,,C1CCOC1,,O,CC(C)(C)[O-].[K+],val
US20140256734A1,CCOC(=O)NN.CN(c1nc(C#N)cc2ccccc12)[C@H]1CCN(C(=O)OC(C)(C)C)C1>>CN(c1nc(-c2n[nH]c(=O)[nH]2)cc2ccccc12)[C@H]1CCN(C(=O)OC(C)(C)C)C1,,CCOC(C)=O,,CN1CCCC1=O,,val
US05733914,CCCI.Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(O)nc2n1>>CCCn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(N)nc21,,CN(C)C=O,,[H-].[Na+],,val
US20070037862A1,CC(=O)Nc1ccc([N+](=O)[O-])cc1.CI>>CC(=O)N(C)c1ccc([N+](=O)[O-])cc1,,CC(C)=O,,[K+].[OH-],,val
US20120010188A1,C=O.Cc1ccc2nc(-c3cccc([N+](=O)[O-])c3)cn2c1>>Cc1ccc2nc(-c3cccc([N+](=O)[O-])c3)c(CO)n2c1,,CC#N,CC(=O)O,O,CC(=O)[O-].[Na+],val
US20150322035A1,Cc1ccc(S(=O)(=O)Nc2ccc(C#N)cc2NS(=O)(=O)c2ccc(C)cc2)cc1.OO>>Cc1ccc(S(=O)(=O)Nc2ccc(C(N)=O)cc2NS(=O)(=O)c2ccc(C)cc2)cc1,,Cl,,[Na+].[OH-],,val
US20100130538A1,CCN=C=O.Cc1cc2c([C@@H]3C[C@H]3CN)cccn2n1>>CCNC(=O)NC[C@@H]1C[C@H]1c1cccn2nc(C)cc12,,C1CCOC1,,,,val
US20100016279A1,C=C(C)C.FC(F)(F)c1nnc2ccc(N3CCC(COC4CCOCC4)CC3)nn12>>CC(C)(C)OCC1CCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20110070317A1,CC1(NC(=O)OC(C)(C)C)CCCNC1.ClCCl.O=C(Nc1c[nH]c2ncc(Br)c(F)c12)c1cccnc1>>CC1(N)CCCN(c2c(Br)cnc3[nH]cc(NC(=O)c4cccnc4)c23)C1.Cl,,CCCCO,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20080293770A1,CC(C)(C)OC(=O)N1CCC(Nc2cc(Br)c(F)cc2N)CC1.O=C(c1ncc[nH]1)c1ncc[nH]1>>CC(C)(C)OC(=O)N1CCC(n2c(=O)[nH]c3cc(F)c(Br)cc32)CC1,,C1CCOC1,,,,val
US20110136827A1,CC(=O)N1CCNCC1.CC(C)(C)OC(=O)NO.O=C(Cl)OC(Cl)(Cl)Cl>>CC(=O)N1CCN(C(=O)ONC(=O)OC(C)(C)C)CC1,,C1CCOC1,ClCCl,CCN(CC)CC,c1ccncc1,val
US20120142625A1,CON(C)C(=O)C1CC(Cc2nc3cc(C(C)(C)C)ccc3[nH]2)C1.C[Si](C)(C)CCOCCl>>CON(C)C(=O)C1CC(Cc2nc3cc(C(C)(C)C)ccc3n2COCC[Si](C)(C)C)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140194411A1,CCOC(=O)N1CCc2ccc3c(c2CC1)C(C)(C)C(F)(F)C3>>CC1(C)c2c(ccc3c2CCNCC3)CC1(F)F,,ClC(Cl)Cl,,C[Si](C)(C)I,,val
US20110028445A1,CCOC(=O)[C@@H]1CCCN(C(=O)N2CC[C@@]3(C)c4ccccc4C[C@@H]2C3(C)C)C1>>CC1(C)[C@H]2Cc3ccccc3[C@]1(C)CCN2C(=O)N1CCC[C@@H](CO)C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04873232,C=Cc1cccc(NC(=O)OCC)c1C(=O)O>>CCOC(=O)Nc1cccc(CC)c1C(=O)O,[Pd],CCO,,,,val
US20080221148A1,Clc1ccc(CBr)cc1.O=c1cc(CO)occ1O>>O=c1cc(CO)occ1OCc1ccc(Cl)cc1,,CO,O,[Na+].[OH-],,val
US03946000,CC(C)(C)OC(=O)NCC1=C(CC(=O)NC2C(=O)N3C(C(=O)O)=C(CSc4c[nH]nn4)CS[C@H]23)CCCC1>>NCC1=C(CC(=O)NC2C(=O)N3C(C(=O)O)=C(CSc4c[nH]nn4)CS[C@H]23)CCCC1,,CCOCC,,O=C(O)C(F)(F)F,,val
US20160002269A1,C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCOCC1.Cl>>C[C@@H](O)[C@H]([NH3+])C(=O)N1CCOCC1.[Cl-],,C1COCCO1,CO,,,val
US20150344425A1,N#CC1(c2ccc(Cl)cc2)CCCCC1>>NCC1(c2ccc(Cl)cc2)CCCCC1,,C1CCOC1,,Cl,,val
US20160096827A1,COc1cc(N)cc(F)c1N1CCN(C2COC2)CC1.N#Cc1cc(-c2ncnc(Cl)n2)ccc1OC1CCOCC1>>COc1cc(Nc2ncnc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)cc(F)c1N1CCN(C2COC2)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20110065691A1,Brc1ccc2[nH]nc(C3CCC3)c2c1.CCI>>CCn1nc(C2CCC2)c2cc(Br)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20020143022A1,COC(=O)c1ccc2[nH]c(SC)cc2c1.O=Cc1ccc(Cl)cc1Cl>>COC(=O)c1ccc2[nH]c(SC)c(Cc3ccc(Cl)cc3Cl)c2c1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20130172389A1,Nc1ccccc1N.O=C(O)CCc1cccc(O)c1>>Oc1cccc(CCc2nc3ccccc3[nH]2)c1,,Cl,,,,val
US03956374,C=CC(=O)OC.Cc1cccc(C=CCC(C(=O)C=Cc2ccc(Cl)cc2)c2ccccc2)c1>>Cc1cccc(C=CCC(CCC(=O)O)(C(=O)C=Cc2ccc(Cl)cc2)c2ccccc2)c1,,CO,COCCOC,,,val
US20070135476A1,CN1CCc2nc(Br)sc2C1.Cc1ccc(S(=O)(=O)O)cc1>>CN1CCc2nc(Br)sc2C1.Cc1ccc(S(=O)(=O)O)cc1,,CO,,O,,val
US06395738B1,CCOC(=O)c1cc2c(C=O)ccc(OC)c2o1.Cc1ncc(Cl)cc1Cl>>COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2cc(C(=O)O)oc12,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US20080096955A1,C[C@@H]1CCCN1.Clc1cc(Br)ccc1CBr>>C[C@@H]1CCCN1Cc1ccc(Br)cc1Cl,,CN(C)C=O,,Br,O=C([O-])[O-].[K+].[K+],val
US20150218096A1,COC(=O)c1c(Cl)cccc1C1=CCCCC1>>COC(=O)c1c(Cl)cccc1C1CCCCC1,[Pd],CCOC(C)=O,,,,val
US05589500,CC/C(=C(\c1ccc(I)cc1)c1ccc(OCCCCCl)cc1)c1ccccc1.CNC>>CC/C(=C(\c1ccc(I)cc1)c1ccc(OCCCCN(C)C)cc1)c1ccccc1,,CO,,CCOCC,,val
US20100144672A1,BrBr.Nc1cc(C(F)(F)F)nn1-c1ncccn1>>Nc1c(Br)c(C(F)(F)F)nn1-c1ncccn1,,CC(=O)O,,O,,val
US04000164,CCCCCCCC/C=C\CCCCCCCCOc1cc(C(=O)O)co1.O=S(Cl)Cl>>CCCCCCCC/C=C\CCCCCCCCOc1cc(C(=O)Cl)co1,,ClCCl,,,,val
US05872118,CC(C)(CC(=O)Cl)c1ccc(F)cc1>>CC1(C)CC(=O)c2cc(F)ccc21,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20120323035A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=Cc1ccccc1O>>CC(C)(C)OC(=O)Oc1ccccc1C=O,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20020016328A1,CCC(CC)Oc1nc(C)nc(Nc2c(C)cc(C)cc2C)c1Br.O=C=O>>CCC(CC)Oc1nc(C)nc(Nc2c(C)cc(C)cc2C)c1C(=O)O,,C1CCOC1,,[Li]CCCC,,val
US20040092546A1,NN.O=C(c1cccnc1Cl)c1[nH]ccc1-c1ccccc1>>c1ccc(-c2cc[nH]c2-c2n[nH]c3ncccc23)cc1,,CCO,,O,,val
US20130178459A1,CC(C)(O)C(C)(C)O.OB(O)c1ccc(OCCCBr)cc1>>CC1(C)OB(c2ccc(OCCCBr)cc2)OC1(C)C,,CCOCC,,,,val
US20120175598A1,CC(=O)n1c2ccccc2c2cc(Br)ccc21.c1ccc(N(c2ccccc2)c2ccc(Nc3cccc4ccccc34)cc2)cc1>>c1ccc(N(c2ccccc2)c2ccc(N(c3ccc4[nH]c5ccccc5c4c3)c3cccc4ccccc34)cc2)cc1,O=[Cu],,,,,val
US20160145218A1,COc1ccc(C/C(C)=N\[S@@](=O)C(C)(C)C)c(Cl)c1>>COc1ccc(C[C@H](C)N[S@@](=O)C(C)(C)C)c(Cl)c1,,C1CCOC1,O,[BH4-].[Na+],,val
US20070197566A1,C=C(C)c1nc2ccc(Cl)cc2c(=O)[nH]1.C[Si](C)(C)C=[N+]=[N-]>>CC1(c2nc3ccc(Cl)cc3c(=O)[nH]2)CC=NN1,,C1CCOC1,,,,val
US05948819,CN.COC(=O)C(OC)c1ccccc1O/N=C(\C)c1ccc(Cl)cc1>>CNC(=O)C(OC)c1ccccc1O/N=C(\C)c1ccc(Cl)cc1,,CO,,,,val
US20110212973A1,COC(=N)C(Cl)(Cl)Cl.Nc1ccc(F)cc1N>>Fc1ccc2nc(C(Cl)(Cl)Cl)[nH]c2c1,,CC(=O)O,,,,val
US20100160303A1,CCOC(OCC)OCC.Cc1c(N)cccc1Br.Nc1ccc(F)cc1C(=O)O>>Cc1c(Br)cccc1-n1cnc2ccc(F)cc2c1=O,,C1CCOC1,CCOC(C)=O,,,val
US20110195977A1,CCOC(=O)/C=C/c1ccc(Cl)c(O)c1>>O=C(O)/C=C/c1ccc(Cl)c(O)c1,,CC(=O)O,Cl,,,val
US20050197350A1,CN(C)c1nc(N[C@@H]2CC[C@H](CN)CC2)nc2c1CCCC2.O=C(Cl)c1ccc(F)c(F)c1>>CN(C)c1nc(N[C@@H]2CC[C@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc2c1CCCC2.Cl,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US04397790,CCOC[PH](=O)Cc1c(Cl)cccc1C(=O)O>>O=C(O)c1cccc(Cl)c1C[PH](=O)CO,,C1COCCO1,,Cl,,val
US20160024103A1,CCC(C)c1cc2oc(-c3ccc(F)cc3)c(C(=O)NC)c2cc1O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCC(C)c1cc2oc(-c3ccc(F)cc3)c(C(=O)NC)c2cc1OS(=O)(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20090270364A1,C1=CCCC=C1.O=C1C=CCCCC1>>O=C1CCCCC2C3C=CC(CC3)C12,,Cc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20140094623A1,CC(=O)N(C)C.CC(=O)OC(C)=O.CCCCCC.O>>CCC1=CC2C(=O)CC2C1,,CC(=O)N(C)C,,CCN(CC)CC,,val
US20100120798A1,Cc1ccc(NC(=O)C2(CN=C(c3ccccc3)c3ccccc3)CCN(C(=O)OC(C)(C)C)CC2)nc1>>Cc1ccc(NC(=O)C2(CN=C(c3ccccc3)c3ccccc3)CCNCC2)nc1,,C1COCCO1,CO,Cl,,val
US20080214615A1,CNCc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O.O=C=Nc1ccc(Cl)c(Cl)c1>>CN(Cc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O)C(=O)Nc1ccc(Cl)c(Cl)c1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20110319378A1,C=CC[C@@H]1C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)NC1=O.CC(C)CBr>>C=CC[C@@H]1C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N(CC(C)C)C1=O,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US04282245,CC(C(=O)O)c1ccc2c(c1)C(=O)Cc1cc([N+](=O)[O-])ccc1S2.CO>>COC(=O)C(C)c1ccc2c(c1)C(=O)Cc1cc([N+](=O)[O-])ccc1S2,,CC(=O)O,,O=C([O-])O.[Na+],,val
US20100240702A1,Cc1cccc2scc(Cn3c(=O)n(CCN)c4ccccc43)c12.O=C=NS(=O)(=O)c1ccccc1>>Cc1cccc2scc(Cn3c(=O)n(CCNC(=O)NS(=O)(=O)c4ccccc4)c4ccccc43)c12,,ClCCl,O,CCN(CC)CC,Cl,val
US04881967,C=CCc1c(O)c(Cl)cc(F)c1N1C(=O)C2=C(CCCC2)C1=O.O=C(OO)c1cccc(Cl)c1>>O=C1C2=C(CCCC2)C(=O)N1c1c(F)cc(Cl)c2c1CC(CO)O2,,ClCCCl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050187409A1,CC(=O)c1ccc(C(=O)O)cc1.CC(=O)c1ccc(N)cc1>>CC(=O)c1ccc(NC(=O)c2ccc(C(C)=O)cc2)cc1,CN(C)C=O,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20080234314A1,OCc1cc2c(cc1I)OCO2>>O=Cc1cc2c(cc1I)OCO2,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20150133451A1,CC1CCN(c2nn(C)cc2NC(=O)c2coc(-c3ccnc(NCC(F)(F)F)c3)n2)C1=O>>C[C@H]1CCN(c2nn(C)cc2NC(=O)c2coc(-c3ccnc(NCC(F)(F)F)c3)n2)C1=O,,CCCCCC,CCO,,,val
US20070161673A1,Cc1cc(-c2cc(C(=O)NC3CC3)cc(F)c2C)ncc1[N+](=O)[O-]>>Cc1cc(-c2cc(C(=O)NC3CC3)cc(F)c2C)ncc1N,[Pd],CCO,,,,val
US08394902B2,CC(C)c1cccc(C(C)C)c1N.Cc1ccccc1NCc1ccc2ccccc2c1-c1cccc(C=O)n1>>Cc1ccccc1NCc1ccc2ccccc2c1-c1cccc(C=Nc2c(C(C)C)cccc2C(C)C)n1,,CCO,,,,val
US20110201608A1,CC(=O)Cl.NC1CCC(Nc2nc(-c3ccc(N4CCOCC4)cc3)cc3ncccc23)CC1>>CC(=O)NC1CCC(Nc2nc(-c3ccc(N4CCOCC4)cc3)cc3ncccc23)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070207994A1,Cn1ncc(Cl)c1-c1cc(N)ccc1OCCN1CC(O)C1.O=C=Nc1ccc(Cl)cc1>>Cn1ncc(Cl)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CC(O)C1,,CN(C)C=O,ClCCl,,,val
US20120316151A1,O=C(C[C@@H]1CCN(C(=O)C2CC2)C1)NNC(=O)Nc1ccc(Br)cc1Cl>>O=C(C1CC1)N1CC[C@@H](Cc2n[nH]c(=O)n2-c2ccc(Br)cc2Cl)C1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20080027049A1,Nc1ccc2oc3c(c2c1)CCCCCC3.O=C(Cl)c1ccco1>>O=C(Nc1ccc2oc3c(c2c1)CCCCCC3)c1ccco1,,ClCCl,,,,val
US05521170,CC1Nc2ccccc2C1C.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>CC1c2ccccc2N(C(=O)c2ccc([N+](=O)[O-])cc2)C1C,,ClCCl,,CCN(CC)CC,,val
US05578627,CSC[C@H](N)COc1noc2ccc(Cl)cc12.O=C(OO)c1cccc(Cl)c1>>CS(=O)C[C@H](N)COc1noc2ccc(Cl)cc12,,ClCCl,,O=C([O-])O.[Na+],,val
US04273773,CCC(C1OC(=O)c2ccccc21)[N+](=O)[O-].COS(=O)(=O)OC>>CCC(=Cc1ccccc1C(=O)OC)[N+](=O)[O-],,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090221604A1,COC(=O)/C(C)=C/c1sc(N2CCN(c3ccc(OC)cc3)CC2)nc1-c1ccccc1>>COc1ccc(N2CCN(c3nc(-c4ccccc4)c(/C=C/C(=O)O)s3)CC2)cc1,,CCO,O,[Li+].[OH-],,val
US04115398,ClCC=Cc1ccccc1Cl.c1ccc2c(c1)CNC2>>Cl.Clc1ccccc1C=CCN1Cc2ccccc2C1,,CCO,,,,val
US20050038050A1,CN(C)C=O.Cc1ccc(S(=O)(=O)OCC(F)(F)F)cc1.Oc1ccc2c(Nc3c(Cl)ccc4c3OCO4)ncnc2c1>>FC(F)(F)COc1cc(OC2CCNCC2)c2c(Nc3c(Cl)ccc4c3OCO4)ncnc2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090163715A1,CC1(C)C=C(c2ccccc2NC(=O)C(C)(C)C)CC(C)(C)C1>>CC1(C)CC(c2ccccc2NC(=O)C(C)(C)C)CC(C)(C)C1,[Pd],CCO,,,,val
US20080280945A1,CC1(C)COC(=O)[C@@H]1OC1CCCCO1.CN>>CNC(=O)[C@H](OC1CCCCO1)C(C)(C)CO,,CO,,,,val
US20130005707A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1nc2cccc(Br)n2n1>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1nc2cccc(Br)n2n1,CN(C)c1ccncc1,CC#N,,,,val
US20020103229A1,CCOC(=O)CCc1nnc(-c2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)[nH]1>>O=C(O)CCc1nnc(-c2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)[nH]1,,C1CCOC1,,O,[Li+].[OH-],val
US20100184808A1,CC1=C[C@@H]2[C@H]3CO[C@H](c4ccccc4)N3C(=O)[C@@H]2C1>>CC1C[C@H]2C(=O)N3[C@H](CO[C@@H]3c3ccccc3)[C@H]2C1,[Pd],CCO,,,,val
US04831041,C#CCc1c(C)nc2c(OCc3c(C)cccc3N)cccn12.O=C(N=C=S)c1ccccc1>>C#CCc1c(C)nc2c(OCc3c(C)cccc3NC(=S)NC(=O)c3ccccc3)cccn12,,ClCCl,,,,val
US20030096828A1,C=O.CC(C)(C)OC(=O)N1CCC(CNCC2CCN(C(=O)OC(C)(C)C)CC2)CC1>>CN(CC1CCN(C(=O)OC(C)(C)C)CC1)CC1CCN(C(=O)OC(C)(C)C)CC1,,CC#N,CC(=O)O,[Na+].[OH-],,val
US04897401,Cc1coc(CN)c1.O=[N+]([O-])c1cccnc1Cl>>Cc1coc(CNc2ncccc2[N+](=O)[O-])c1,,CCO,,O=C([O-])O.[Na+],,val
US20120004203A1,CC1=C(C#N)[C@@H](c2ccc(C#N)cc2)n2nc(N)nc2N1c1cccc(C(F)(F)F)c1.CCN=C=O>>CCNC(=O)Nc1nc2n(n1)[C@H](c1ccc(C#N)cc1)C(C#N)=C(C)N2c1cccc(C(F)(F)F)c1,,c1ccncc1,,O=S(=O)([O-])[O-].[Na+].[Na+],,val
US06184225B2,COc1cc2c(Oc3ccccc3)ncnc2cc1OCCN1CCN(C)CC1>>COc1cc2c(=O)[nH]cnc2cc1OCCN1CCN(C)CC1,,Cl,,O=C([O-])O.[Na+],,val
US20110130415A1,CC(C)O.O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(C(F)(F)F)c1>>CC(C)Oc1c([N+](=O)[O-])cc([N+](=O)[O-])cc1C(F)(F)F,,C1CCOC1,,[H-].[Na+],,val
US06384281B1,COc1ccc2cc([C@@H]3[C@@H](CN(C)C)[C@H]4CC[C@@H]3C4)ccc2c1>>CN(C)C[C@H]1[C@H]2CC[C@H](C2)[C@@H]1c1ccc2cc(O)ccc2c1,,CN(C)C=O,,O,,val
US04831032,Cn1c(=O)[nH]c2cc([N+](=O)[O-])c([N+](=O)[O-])cc21>>Cn1c(=O)[nH]c2cc(N)c(N)cc21,O=[Pt],CO,,[H][H],,val
US20030149036A1,OCC1(Cc2ccccc2)CCN(Cc2ccccc2)CC1>>OCC1(Cc2ccccc2)CCNCC1,,ClCCl,,CC(Cl)OC(=O)Cl,,val
US06525055B1,COc1ccc2c(Cc3c(Cl)cncc3Cl)nnc(Cl)c2c1.NN>>COc1ccc2c(Cc3c(Cl)cncc3Cl)nnc(NN)c2c1,,CCO,,O,,val
US05998433,CCCCCCCc1ccc(C(=O)N2CCc3oc(CN(C)C)cc3C2)cc1.Cl>>CCCCCCCc1ccc(C(=O)N2CCc3oc(CN(C)C)cc3C2)cc1.Cl,,CCOC(C)=O,CO,,,val
US20150148313A1,COC(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2>>Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C(=O)O)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc2c1,,C1CCOC1,,[Li+].[OH-],,val
US20060183732A1,C=CC[C@@H](NC(=O)OCc1ccccc1)C(=O)O.CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CC=C[C@H]1c1ccccc1>>C=CC[C@@H](NC(=O)OCc1ccccc1)C(=O)N(C)C(C=C)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US04402730,C=C(Cl)CCl.CCCCCCNc1nc(C)cc(O)n1>>C=C(Cl)COc1cc(C)nc(NCCCCCC)n1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110195954A1,COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)O)ncn3)CC1)C(=O)N2.c1n[nH]c2c1CCNCC2>>COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)N4CCc5cn[nH]c5CC4)ncn3)CC1)C(=O)N2,,CN(C)C=O,,Cl,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090318441A1,CCC(CC)n1ccc2cnc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cc3)nc21>>CCC(CC)n1ccc2cnc(Nc3ccc(N4CCNCC4)cc3)nc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160096834A1,Brc1ccc(Br)nc1.CCOC(=O)C(=O)OCC>>CCOC(=O)C(=O)c1ccc(Br)nc1,,CCOCC,,[Li]CCCC,,val
US20090298823A1,CC(=O)N1CCN(c2ccc(N)cc2)CC1.Cc1ccc(S(=O)(=O)n2cc(C#N)c3c(NC4CC4)nc(Cl)nc32)cc1>>CC(=O)N1CCN(c2ccc(Nc3nc(NC4CC4)c4c(C#N)c[nH]c4n3)cc2)CC1,,CCCCO,,C[Si](C)(C)Cl,,val
US20080114022A1,COC(=O)n1c(C)cc2ccc(Cl)nc21>>Cc1cc2ccc(Cl)nc2[nH]1,,CO,,[Na+].[OH-],,val
US20160122300A1,CCI.Nc1cc(O)c(C(=O)CCC2CCN(CC3CCCCC3)CC2)cc1Cl>>CCOc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCCC2)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US07005440B1,COC(=O)c1c(C)cccc1COc1cccc(OCc2ccc3ccccc3n2)c1>>Cc1cccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c1C(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20050261317A1,Nc1ccc(Cl)cc1C(=O)O.Nc1ccccc1Cl>>Nc1ccc(Cl)cc1C(=O)Nc1ccccc1Cl,,c1ccccc1,,O=S(Cl)Cl,,val
US20150152080A1,Nc1cccnc1SCc1ccccc1.O=S(=O)(Cl)c1cc2ccccc2s1>>O=S(=O)(Nc1cccnc1SCc1ccccc1)c1cc2ccccc2s1,,c1ccncc1,,,,val
US06303556B1,C=CCC(C)C=C(C)C=CC(C)=O>>CCCC(C)CC(C)CCC(C)O,[Ru],CO,,,,val
US20100022526A1,CO.Fc1cc(F)c(-c2c(Cl)nnc(Cl)c2-c2ccc(Br)cc2)c(F)c1>>COc1nnc(Cl)c(-c2c(F)cc(F)cc2F)c1-c1ccc(Br)cc1,,O,,C[O-].[Na+],,val
US05491144,COC(=O)c1cc(Nc2ccc(OC)cc2)c(Nc2ccc(OC)cc2)cc1C(=O)OC.N>>COc1ccc(Nc2cc3c(cc2Nc2ccc(OC)cc2)C(=O)NC3=O)cc1,,OCCO,,[Cl-].[Na+],,val
US04360660,CN(C)c1ccc(C=O)cc1.CN(CCN(C)c1ccccc1)c1ccccc1>>c1ccc(C(c2ccccc2)c2ccccc2)cc1,,O,,[Na+].[OH-],,val
US20140330026A1,CCOC(=O)C(C)(C(=O)OCC)c1ccc([N+](=O)[O-])cc1F>>CC(C(=O)O)c1ccc([N+](=O)[O-])cc1F,,CC(=O)O,O,O=S(=O)(O)O,,val
US03991076,C1=C(N2CCCC2)CCSC1.O.O=C(CBr)c1ccc(Cl)cc1>>O=C(CC1CSCCC1=O)c1ccc(Cl)cc1,,O,,CN(C)C=O,,val
US05665749,Fc1cc(Br)cc(OCc2ccccc2)c1.O=C1CCOCC1>>OC1(c2cc(F)cc(OCc3ccccc3)c2)CCOCC1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US06380215B1,Cl.O=C(O)CCNC(=O)C1CCCN(C(=O)COC2CCN(C(=O)OCc3ccccc3)CC2)C1>>Cl.O=C(O)CCNC(=O)C1CCCN(C(=O)COC2CCNCC2)C1,[Pd],C1CCOC1,,,,val
US20150299189A1,CC(C)(C)OC(=O)c1cc(C2CC2)cnc1Nc1cccc2c1ccn2CC1CCC1>>O=C(O)c1cc(C2CC2)cnc1Nc1cccc2c1ccn2CC1CCC1,,C1CCOC1,CO,[Na+].[OH-],,val
US20090062558A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCCCC=CCCC(F)(F)C(F)(F)F>>Cc1ccc(S(=O)(=O)OCCCC=CCCC(F)(F)C(F)(F)F)cc1,,ClCCl,,CCN(CC)CC,,val
US04789677,CNCCNC.O=S(=O)(Cl)c1ccc(F)cc1>>CNCCN(C)S(=O)(=O)c1ccc(F)cc1,,ClC(Cl)Cl,,O,O=C([O-])[O-].[Na+].[Na+],val
US20070155839A1,CC(C)(C)OC(=O)/C=C/c1ccc(C(=C2CCOCC2)c2ccc(O)cc2)cc1>>O=C(O)/C=C/c1ccc(C(=C2CCOCC2)c2ccc(O)cc2)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US05283248,CC(C)(C)OC(=O)N1CCN(c2cc(NC3CC3)c([N+](=O)[O-])cc2F)CC1.CCOC(=N)CC(=O)OCC>>CCOC(=O)Cc1nc2cc(F)c(N3CCN(C(=O)OC(C)(C)C)CC3)cc2n1C1CC1,[Pd],CO,,Cl,[H][H],val
US20080306082A1,CN1CCN(CCCNc2nccc(-c3cc4ccc(Br)cc4s3)n2)CC1.CNC(=O)c1cccc(B(O)O)c1>>CNC(=O)c1cccc(-c2ccc3cc(-c4ccnc(NCCCN5CCN(C)CC5)n4)sc3c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CS(C)=O,O,O=C([O-])O.[Na+],,val
US20080027090A1,Nc1cc2c3c(c1)c1c(n3CCC2)CCCCC1.O=C(Cl)CCc1ccccc1>>O=C(CCc1ccccc1)Nc1cc2c3c(c1)c1c(n3CCC2)CCCCC1,,ClCCl,,,,val
US20070010537A1,CCN(c1ccccc1)S(=O)(=O)c1ccc(C)c(N)c1.COC(=O)c1ccccc1N=C=O>>CCN(c1ccccc1)S(=O)(=O)c1ccc(C)c(-n2c(=O)[nH]c3ccccc3c2=O)c1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20080009530A1,COCOc1ccc(C(=O)OC)c(OCc2ccc(Cl)cc2Cl)c1C>>COCOc1ccc(C(=O)O)c(OCc2ccc(Cl)cc2Cl)c1C,,C1CCOC1,CO,O,[Na+].[OH-],val
US20080234284A1,CCOC(C)=O.N#CCc1cccc(Cl)c1>>CC(=O)C(C#N)c1cccc(Cl)c1,,CCO,,[Na],,val
US20070232676A1,CN(C)/C=C1/CN(C(c2ccccc2)(c2ccccc2)c2ccccc2)CC1=O.CNN>>Cn1ncc2c1CN(C(c1ccccc1)(c1ccccc1)c1ccccc1)C2,,CCO,,,,val
US20110152240A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CSc1nc(NC2CC2)n2nccc2n1>>CSc1nc(N(C(=O)OC(C)(C)C)C2CC2)n2nccc2n1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,,,val
US06258953B1,C=CC(=O)Cl.Nc1ccc(Cl)c(Cl)c1>>C=CC(=O)Nc1ccc(Cl)c(Cl)c1,,ClCCl,,CCN(CC)CC,,val
US20120258946A1,NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1.O=C(Nc1ccc(CCO)c(F)c1)Oc1ccccc1>>O=C(NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1)Nc1ccc(CCO)c(F)c1,,C1CCOC1,,Cl,,val
US20150119404A1,CCOc1ccc(F)c(-c2cc(C)nc(Cl)n2)c1.I>>CCOc1ccc(F)c(-c2cc(C)nc(I)n2)c1,,ClCCl,,,,val
US03971819,COCCN.NS(=O)(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1Cl>>COCCNc1c([N+](=O)[O-])cc(C(=O)O)cc1S(N)(=O)=O,,CCO,,,,val
US20060167081A1,COP(=O)(CC(=O)C(F)(F)c1ccccc1)OC.COc1ccc(CN2C(=O)CCC2C=O)cc1>>COc1ccc(CN2C(=O)CC[C@@H]2/C=C/C(=O)C(F)(F)c2ccccc2)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20060094747A1,C=CCOC(=O)CC(=O)OCC=C.FC(F)(F)c1cccc(CBr)c1>>C=CCOC(=O)C(Cc1cccc(C(F)(F)F)c1)C(=O)OCC=C,,C1CCOC1,O,Cl,[H-].[Na+],val
US20150105373A1,CCC(N)c1ccc(OC(F)(F)F)cc1.O=C1CN(C(=O)Oc2ccc([N+](=O)[O-])cc2)c2ncc(C(F)(F)F)cc2N1>>CCC(NC(=O)N1CC(=O)Nc2cc(C(F)(F)F)cnc21)c1ccc(OC(F)(F)F)cc1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20060217372A1,N#Cc1cc(F)c(Oc2ccc(C=O)cc2)c(F)c1.OO>>NC(=O)c1cc(F)c(Oc2ccc(C=O)cc2)c(F)c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160083380A1,C#CCCl.CC(=NOCc1ccc(C(F)(F)F)cc1)c1ccc(O)cc1>>C#CCOc1ccc(C(C)=NOCc2ccc(C(F)(F)F)cc2)cc1,,O,,CN(C)C=O,,val
US20110218197A1,Cn1nc(C(C)(C)C)c(Cl)c1C(=O)Nc1nc(-c2ccccc2C(F)(F)F)cc(Cl)c1[N+](=O)[O-]>>Cn1nc(C(C)(C)C)c(Cl)c1C(=O)Nc1nc(-c2ccccc2C(F)(F)F)cc(Cl)c1N,[Fe],CCO,,O,[Cl-].[NH4+],val
US20090074791A1,C#CCOc1ccc2nc(-c3nc4ccc(C(=O)OCC)cc4n3C)nc(-c3ccc(C(C)C)cc3)c2c1>>C#CCOc1ccc2nc(-c3nc4ccc(C(=O)O)cc4n3C)nc(-c3ccc(C(C)C)cc3)c2c1,,CCO,,[Na+].[OH-],,val
US20110172202A1,CC(C)(C)OC(=O)N[C@@H]1CCc2c(C#N)cccc21.NO>>CC(C)(C)OC(=O)N[C@@H]1CCc2c(C(=N)NO)cccc21,,CCO,,Cl,,val
US20120295874A1,COC(=O)CCOc1ccc(CNC(=O)OC(C)(C)C)cc1>>COC(=O)CCOc1ccc(CN)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120059000A1,C=Cc1cccc2cc([C@H](C)Nc3ncnc4[nH]cnc34)n(-c3ccccc3)c(=O)c12.O=[Os](=O)(=O)=O>>C[C@H](Nc1ncnc2[nH]cnc12)c1cc2cccc(C=O)c2c(=O)n1-c1ccccc1,O=[Os](=O)(=O)=O,C1COCCO1,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US06368814B1,CC(C)(C)OC(=O)NCCBr.CNCCCN1c2ccccc2CCc2ccccc21>>CC(C)(C)OC(=O)NCCNCCCN1c2ccccc2CCc2ccccc21,C1COCCOCCOCCOCCOCCO1,CC(C)=O,CN(C)C=O,[I-].[K+],O=C([O-])O.[Na+],val
US20110257100A1,COCCN(CCc1ccc(Br)nc1)C(=O)OC(C)(C)C.Clc1ccnc2ccsc12>>COCCN(CCc1ccc(-c2cc3nccc(Cl)c3s2)nc1)C(=O)OC(C)(C)C,,C1CCOC1,,[Li]CCCC,,val
US20040102548A1,O=S(=O)(O)Cl.O=S(Cl)Cl.c1ccc2c(c1)-c1nc-2nc2[nH]c(nc3nc(nc4[nH]c(n1)c1ccccc41)-c1ccccc1-3)c1ccccc21>>O=S(=O)(Cl)Cl.c1ccc2c(c1)-c1nc-2nc2[nH]c(nc3nc(nc4[nH]c(n1)c1ccccc41)-c1ccccc1-3)c1ccccc21,,O,,,,val
US20160264573A1,CC(C)(C)OC(=O)N1C[C@H](NOCc2ccccc2)CC[C@H]1C(=O)O.N#Cc1ccc(O)cc1>>CC(C)(C)OC(=O)N1C[C@H](NOCc2ccccc2)CC[C@H]1C(=O)Oc1ccc(C#N)cc1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCN=C=NCCCN(C)C,Cl,val
US20140171316A1,O=C(O)c1cnn(CC(F)(F)F)c1-c1ncccc1Cl.O=S(Cl)Cl>>O=C(Cl)c1cnn(CC(F)(F)F)c1-c1ncccc1Cl,,Cc1ccccc1,,CN(C)C=O,,val
US20050020585A1,C#Cc1ccccn1.C[Si](C)(C)N=[N+]=[N-]>>c1ccc(-c2cn[nH]n2)nc1,,O,,CCOCC,,val
US20130065901A1,Nc1ncc(Br)cc1Sc1ccccc1.S=C=Nc1cccnc1Cl>>Brc1cnc(Nc2nc3cccnc3s2)c(Sc2ccccc2)c1.Cl,,ClCCl,,CN(C)C=O,,val
US20120309738A1,CNc1ccc(N2CCC(C(F)(F)F)CC2)cc1NC(=S)Nc1cc(CNC(=O)C(C)(C)C)ccc1Cl>>CN1c2ccc(N3CCC(C(F)(F)F)CC3)cc2NC1Nc1cc(CNC(=O)C(C)(C)C)ccc1Cl,,CC#N,,CC(C)N=C=NC(C)C,,val
US04681891,CC1=C(C(=O)OCCC#N)C(c2cccc(Cl)c2Cl)C(c2nnco2)=C(C)N1>>CC1=C(C(=O)O)C(c2cccc(Cl)c2Cl)C(c2nnco2)=C(C)N1,,COCCOC,O,[Na+].[OH-],,val
US20100056521A1,CCOC(=O)c1cccc(I)c1.N#Cc1c[nH]c2ccccc12>>CCOC(=O)c1cccc(-n2cc(C#N)c3ccccc32)c1,I[Cu]I,CS(C)=O,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150166521A1,CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.COC(=O)CCCC[S@@](C)(=N)=O.Cc1ccoc1C(=O)Nc1cccc(C#Cc2cc(C(=O)O)cnc2N)c1>>COC(=O)CCCC[S@](C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3ccc(OC)c(OC)c3)c2)c1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US20050090529A1,CI.Cc1c(Br)cncc1CO>>COCc1cncc(Br)c1C,,C1CCOC1,,[H-].[Na+],,val
US06218376B1,CN.Cn1cc(C2c3ccc(Cl)cc3C=Cc3sc(Cl)nc32)c(=O)[nH]c1=O>>CNc1nc2c(s1)C=Cc1cc(Cl)ccc1C2c1cn(C)c(=O)[nH]c1=O,,CCO,,,,val
US20090270460A1,CC(C)CI.CCOC(=O)C(CC(C)=O)=NOC>>CCOC(=O)C(=NOC)C(CC(C)C)C(C)=O,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20020169322A1,Brc1ccncc1.CCCC[Sn](CCCC)(CCCC)c1ccc2cnn(CCN(C)C)c2c1>>CN(C)CCn1ncc2ccc(-c3ccncc3)cc21,,Cc1ccccc1,,Cl,,val
US20140323486A1,CCNC(=O)Nc1cc(Nc2cccc(C)c2)c(C(=O)OCC)cn1>>CCNC(=O)Nc1cc(Nc2cccc(C)c2)c(C(=O)O)cn1,,[Na+],[OH-],Cl,,val
US05942634,CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(S)CC[C@]4(C)[C@H]3CC[C@]12C.c1ccc(SSc2ccccn2)nc1>>CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(SSc5ccccn5)CC[C@]4(C)[C@H]3CC[C@]12C,,ClCCl,,,,val
US20130059834A1,Cn1nc(-c2cnc3c(n2)c(C(=O)NC2CCC(NC(=O)OC(C)(C)C)C2)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21>>Cn1nc(-c2cnc3[nH]cc(C(=O)NC4CCC(N)C4)c3n2)c2ccc(Cl)cc21,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US20060257987A1,CON(C)C(=O)c1ccccc1.COc1ccc(C(F)(F)F)cc1>>COc1ccc(C(F)(F)F)cc1C(=O)c1ccccc1,,C1CCOC1,,Cl,[Li]CCCC,val
US20100168122A1,CCOC(=O)c1ccsc1.[H]/N=C(/CCCCn1c(=O)c2[nH]c(Cl)nc2n(CCCCC)c1=O)NO>>CCCCCn1c(=O)n(CCCCc2noc(-c3ccsc3)n2)c(=O)c2[nH]c(Cl)nc21,,CCO,,C,C[O-].[Na+],val
US04704218,CC(O)CO.CCCCCCCCCCCCSCCCCCCCCCCCC.COP(O)OC>>CC(O)CO.CCCCCCCCCCCCSCCCCCCCCCCCC.OP(O)O,,CO,,,,val
US04962115,COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(O)C(OC)(OC)c2ccc(F)cc2)C[C@H]1OC>>COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(O)C(=O)c2ccc(F)cc2)C[C@H]1OC,,O,,Cl,N,val
US20060160862A1,CC(C)(C)OC(=O)CC(N)C(O)CF.O=C(Nc1cccn([C@@H](Cc2ccccc2)C(=O)O)c1=O)c1ccccc1>>CC(C)(C)OC(=O)CC(NC(=O)[C@H](Cc1ccccc1)n1cccc(NC(=O)c2ccccc2)c1=O)C(O)CF,CN(C)c1ccncc1,C1CCOC1,,ClCCCl,On1nnc2ccccc21,val
US20150065705A1,CSC(=N)NC(=O)n1ccnc1.NCc1ccc(C(F)(F)F)s1>>CSC(=N)NC(=O)NCc1ccc(C(F)(F)F)s1,,C1CCOC1,,,,val
US07091199B1,BrCCCOc1cccc(-c2noc3ccsc23)c1.NCc1ccc(C(F)(F)F)cc1>>FC(F)(F)c1ccc(CNCCCOc2cccc(-c3noc4ccsc34)c2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20070225271A1,CCOc1cc(CN2CCC(N)CC2)ccc1OC.Cc1ccc2nc(Cl)nc(N)c2c1>>CCOc1cc(CN2CCC(Nc3nc(N)c4cc(C)ccc4n3)CC2)ccc1OC,,CN1CCCC1=O,,,,val
US20140315886A1,O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C1Nc2c(ccc(Cl)c2F)C1=O>>O=c1[nH]c2c(F)c(Cl)ccc2c(=O)o1,,C1CCOC1,,,,val
US20100305096A1,C1CC(C2COC2)CCN1.O=Cc1nc2c(N3CCOCC3)nc(Cl)nc2s1>>Clc1nc(N2CCOCC2)c2nc(CN3CCC(C4COC4)CC3)sc2n1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04388317,CC(=O)O.CN(C)CN(C)C.O=c1[nH]c(NCCSCc2ccco2)ncc1Cc1ccco1>>CN(C)Cc1ccc(CSCCNc2ncc(Cc3ccc(CN(C)C)o3)c(=O)[nH]2)o1,,CC(=O)O,,,,val
US20040209878A1,C=O.NC(=O)C1CCNCC1>>CN1CCC(C(N)=O)CC1,[Pd],O,,,,val
US07053107B2,C#Cc1ccccn1.C[Si](C)(C)CCOCn1nc(I)c2ccc([N+](=O)[O-])cc21>>C[Si](C)(C)CCOCn1nc(C#Cc2ccccn2)c2ccc([N+](=O)[O-])cc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCN(CC)CC,,,,val
US20040259884A1,CCOc1cc(C(F)(F)F)ccc1C1=NC(c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)N1.O=C(Cl)Cl>>CCOc1cc(C(F)(F)F)ccc1C1=NC(c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)N1C(=O)Cl,,ClCCl,,CCN(CC)CC,,val
US20070066573A1,CSc1ccsc1-c1ccc(C=O)cc1.Cc1ccc(S(=O)(=O)CC#N)cc1>>CSc1ccsc1-c1ccc(C=C(C#N)S(=O)(=O)c2ccc(C)cc2)cc1,,Cc1ccccc1,,C1CCNCC1,CC(=O)O,val
US20160168156A1,CCOC(=O)c1cnn2ccc(N3C[C@@H](F)C[C@H]3c3cc(F)ccc3F)nc12>>O=C(O)c1cnn2ccc(N3C[C@@H](F)C[C@H]3c3cc(F)ccc3F)nc12,,CCO,O,[Li+].[OH-],,val
US20090124682A1,CC(C)(C)[Si](C)(C)Cl.OC[C@@H]1c2ccccc2C[C@@H]1O>>CC(C)(C)[Si](C)(C)OC[C@@H]1c2ccccc2C[C@@H]1O,,ClCCl,,c1c[nH]cn1,,val
US20100216788A1,CC(C)(C)NC(=O)c1cccc(-n2ccc3cc([N+](=O)[O-])ccc32)c1>>CC(C)(C)NC(=O)c1cccc(-n2ccc3cc(N)ccc32)c1,[Pt],CCOC(C)=O,,,,val
US20100137281A1,CCc1cc(C(=O)OC)c(N)s1.Nc1cnc2ccccc2c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCc1cc2c(=O)n(-c3cnc4ccccc4c3)c(=O)[nH]c2s1,,ClCCl,,CCN(CC)CC,,val
US20080176857A1,CCc1cc2c(N3CCN(C(=O)Cc4ccccc4)CC3)nc(Cl)nc2s1.O=C(CS)Nc1ccc2ccccc2c1>>CCc1cc2c(N3CCN(C(=O)Cc4ccccc4)CC3)nc(SCC(=O)Nc3ccc4ccccc4c3)nc2s1,,CN(C)C=O,,,,val
US20140275028A1,ClCc1nc2ccccc2s1.O=[N+]([O-])c1cc(O)ccc1F>>O=[N+]([O-])c1cc(OCc2nc3ccccc3s2)ccc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130210825A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nn4c(-c5ccc(S(C)(=O)=O)cc5)cnc4cc3-c3ccccc3)cc2)CCC1>>CS(=O)(=O)c1ccc(-c2cnc3cc(-c4ccccc4)c(-c4ccc(C5(N)CCC5)cc4)nn23)cc1,,C1COCCO1,,Cl,,val
US20160152596A1,CC(C)OC(=O)/C(Br)=C/n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1>>O=C(O)/C(Br)=C/n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US05220021,C=C(P(=O)(OCC)OCC)P(=O)(OCC)OCC.[N-]=[N+]=CC(=O)C1CCCCC1>>CCOP(=O)(OCC)C1(P(=O)(OCC)OCC)CC(C(=O)C2CCCCC2)=NN1,,CCOCC,,,,val
US20040102450A1,Clc1ccnc2cc(CBr)ccc12.O=C1CN(C(=O)OCc2ccccc2)CCN1>>O=C1CN(C(=O)OCc2ccccc2)CCN1Cc1ccc2c(Cl)ccnc2c1,,C1CCOC1,,[H-].[Na+],,val
US05026700,COC(=O)COc1cc(C(=O)OC)nc2ccccc12>>O=C(O)COc1cc(C(=O)O)nc2ccccc12,,CO,O,[Li+].[OH-],,val
US20080255150A1,COC(=O)/C=C/c1ccc(Cl)cc1C=O>>COC(=O)CCc1ccc(Cl)cc1CO,[Pt],CCOC(C)=O,,[H][H],,val
US20080051418A1,CCOC(=O)CBr.CCOc1cc(C(O)c2ccccn2)ccc1O>>CCOC(=O)COc1ccc(C(O)c2ccccn2)cc1OCC,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130190320A1,C=CC(=O)Nc1cccc(C(F)(F)c2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3c2ccn3CO)c1>>C=CC(=O)Nc1cccc(C(F)(F)c2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3[nH]ccc23)c1,,CO,,N,,val
US20130274253A1,CC1(C)OB(c2ccnc(F)c2)OC1(C)C.O=C(Cc1nc(Cl)cc(=O)[nH]1)N1CCc2c(F)cccc21>>O=C(Cc1nc(-c2ccnc(F)c2)cc(=O)[nH]1)N1CCc2c(F)cccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080227794A1,COC(=O)c1ccccc1CBr.NCc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1>>O=C1c2ccccc2CN1Cc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1,,CCCCCC,Cc1ccccc1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20090239864A1,COc1ccc(Br)cc1[C@H]1CN(Cc2ccccc2)CCO1.N#C[Cu]C#N>>COc1ccc(C#N)cc1[C@H]1CN(Cc2ccccc2)CCO1,,CN1CCCC1=O,,CCOCC,[Na+].[OH-],val
US20090270395A1,CC(C)OC(=O)c1ccc(CCN2C(=O)OCC[C@@H]2/C=C/C(=O)C(F)(F)c2cccc(Br)c2)cc1>>CC(C)OC(=O)c1ccc(CCN2C(=O)OCC[C@@H]2/C=C/[C@@H](O)C(F)(F)c2cccc(Br)c2)cc1,,ClCCl,,CCN(CC)CC,O=CO,val
US20120214803A1,Cc1ccc(N)c2ncccc12.O=S(=O)(Cl)c1ccccc1>>Cc1ccc(NS(=O)(=O)c2ccccc2)c2ncccc12,,ClCCl,,,,val
US20120270875A1,COC(=O)C(CO)(NC(=O)c1cccc(O)c1)NC(=O)c1c(C)nc(NCCCc2cccc(O)c2)nc1C>>Cc1nc(NCCCc2cccc(O)c2)nc(C)c1C(=O)NC(CO)(NC(=O)c1cccc(O)c1)C(=O)O,,C1CCOC1,O,[Li+].[OH-],,val
US05661108,COCC(C)c1c(F)c(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)cc2nc(C(F)(F)F)[nH]c12>>CC(CO)n1c(C(F)(F)F)nc2cc(F)c(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)cc21,,ClCCl,,BrB(Br)Br,,val
US04943580,CCOCCn1c(CC2CCN(CCN)CC2)nc2cccnc21.S=C=S>>CCOCCn1c(CC2CCN(CCN=C=S)CC2)nc2cccnc21,,C1CCOC1,,,,val
US06392082B1,C[C@@H](S[C@H]1CO[C@@H](c2ccccc2)OC1)[C@](O)(Cn1cncn1)c1ccc(F)cc1>>C[C@@H](SC(CO)CO)[C@](O)(Cn1cncn1)c1ccc(F)cc1,,CO,,Cl,O=C([O-])O.[Na+],val
US20070244132A1,CCOCCBr.Clc1ncnc2cc[nH]c12>>CCOCCn1ccc2ncnc(Cl)c21,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040077584A1,CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(C(=O)O)nc32)[C@H](O)[C@@H]1O.O=C(NC1CCNCC1)C(F)(F)F>>CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(C(=O)N4CCC(NC(=O)C(F)(F)F)CC4)nc32)[C@H](O)[C@@H]1O,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US05516774,Cc1cccc(C(=O)Cl)c1C.Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1>>Cc1cccc(C(=O)Nc2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)c1C,,ClCCl,,CCN(CC)CC,,val
US20100273786A1,CCNC(=O)c1nc(C(F)(F)F)n2c1CN(C(=O)C[C@@H](Cc1cc(F)c(F)cc1F)NC(=O)OC(C)(C)C)CC2>>CCNC(=O)c1nc(C(F)(F)F)n2c1CN(C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)CC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060122065A1,CC(=O)c1ccc(Cl)cc1.NC=O>>CC(N)c1ccc(Cl)cc1,,O,,O=CO,,val
US20140255392A1,CC(C)(C)OC(=O)N(CC(F)F)c1cc(Br)cn2ccnc12.O=C1CCC(=O)N1I>>CC(C)(C)OC(=O)N(CC(F)F)c1cc(Br)cn2c(I)cnc12,,CN(C)C=O,,,,val
US20120028961A1,CN(C)C(=S)Cl.N#Cc1ccc2c(c1O)CCN(C(=O)C(F)(F)F)CC2>>CN(C)C(=S)Oc1c(C#N)ccc2c1CCN(C(=O)C(F)(F)F)CC2,CN(C)c1ccncc1,C1COCCO1,CCOC(C)=O,CCN(CC)CC,,val
US20160194316A1,CCc1nn(C)c(OC)c1CNC(=O)c1cc(Cl)cc(N(CC)[C@@H]2CC[C@@H](N(C)C)CC2)c1C>>CCc1[nH]n(C)c(=O)c1CNC(=O)c1cc(Cl)cc(N(CC)[C@@H]2CC[C@@H](N(C)C)CC2)c1C,,Cl,,,,val
US20130261107A1,BrCc1ccccc1.O=C1NCCCc2nc(COc3ccccc3)sc21>>O=C1c2sc(COc3ccccc3)nc2CCCN1Cc1ccccc1,,CN(C)C=O,O,[H-].[Na+],,val
US20020091265A1,COC(=O)Nc1cnc(N2CCOCC2)cc1-c1ccccc1C>>CNc1cnc(N2CCOCC2)cc1-c1ccccc1C,,Cc1ccccc1,,[Na+].[OH-],,val
US20130096133A1,CCOC(=O)CN1CCN(Cc2c3ccccc3cc3ccccc23)CC1.NN>>NNC(=O)CN1CCN(Cc2c3ccccc3cc3ccccc23)CC1,,CCO,,,,val
US05068300,CC(C)(C)OC(=O)c1ccc(/C=C\c2ccc(C(=O)OC(C)(C)C)cc2)cc1>>O=C(O)c1ccc(/C=C\c2ccc(C(=O)O)cc2)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090156642A1,CCOC(=O)C#CC(=O)OCC.NNc1cccnc1F>>CCOC(=O)c1cc(O)n(-c2cccnc2F)n1,,CCO,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US05998668,CCC(=O)CC(=O)OC>>CC[C@@H](O)CC(=O)OC,[Ru],ClCCl,,CO,[H][H],val
US20090036467A1,CC(=O)Oc1cccc(C(=O)Cl)c1.CSc1csc(N)n1>>CSc1csc(NC(=O)c2cccc(OC(C)=O)c2)n1,,C1CCOC1,,CCN(CC)CC,,val
US20090215803A1,CC(=O)c1ccc(O)c(C)c1.CCOC(=O)COc1cccc(C=O)c1>>Cc1cc(C(=O)/C=C/c2cccc(OCC(=O)O)c2)ccc1O,,CO,O,Cl,[K+].[OH-],val
US20030096841A1,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)C1CC1>>O=C1CCC(N2C(=O)c3cccc(NC(=O)C4CC4)c3C2=O)C(=O)N1,,C1CCOC1,CCOCC,CO,,val
US20020022638A1,Cc1ccn(-c2ccc(-c3nc4cccnc4n3-c3ccc(CCNC[C@H](O)COc4ccc(O[Si](c5ccccc5)(c5ccccc5)C(C)(C)C)cc4)cc3)c(Cl)c2)n1>>Cc1ccn(-c2ccc(-c3nc4cccnc4n3-c3ccc(CCNCC(O)COc4ccc(O)cc4)cc3)c(Cl)c2)n1,,CO,ClC(Cl)Cl,,,val
US04843062,COC(=O)N(CC(=O)OC(C)(C)C)C(=O)c1cccc2c(C(F)(F)F)c(OC)ccc12>>COC(=O)N(CC(=O)O)C(=O)c1cccc2c(C(F)(F)F)c(OC)ccc12,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20030055097A1,CS(=O)(=O)OS(C)(=O)=O.Cn1cc(C2=C(c3nn(CCCO)c4ccccc34)C(=O)NC2=O)c2cc(Cl)ccc21>>Cn1cc(C2=C(c3nn(CCCOS(C)(=O)=O)c4ccccc34)C(=O)NC2=O)c2cc(Cl)ccc21,,C1CCOC1,,Cl,c1ccncc1,val
US20040143115A1,CC(C)(C)OC(=O)N1CCCC[C@H]1CN.N#Cc1cc(F)c(F)c(F)c1>>CC(C)(C)OC(=O)N1CCCC[C@H]1CNc1c(F)cc(C#N)cc1F,,Cc1ccccc1C,,CCN(C(C)C)C(C)C,,val
US20120010228A1,CC(C)(C)OC(=O)c1ccccc1CN1CN(c2ccccc2)C2(CCNCC2)C1=O.O=c1n(CCCCl)c2ccccc2n1C1CC1>>CC(C)(C)OC(=O)c1ccccc1CN1CN(c2ccccc2)C2(CCN(CCCn3c(=O)n(C4CC4)c4ccccc43)CC2)C1=O,,CCC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20070135427A1,N#CC1(c2ccccc2C(F)(F)F)CCC1.O=S(=O)(O)O>>O=CC1(c2ccccc2C(F)(F)F)CCC1,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20090042890A1,CCOC(=O)c1nc(N[C@H]2CCN(C(=O)OC(C)(C)C)C2)nc(Nc2ccccc2OC)c1N.CCOC(=O)c1nc(N[C@H]2CCN(C(=O)OC(C)(C)C)C2)nc2c1[nH]c(=O)n2-c1ccccc1OC>>COc1ccccc1-n1c(=O)[nH]c2c(C(N)=O)nc(N[C@H]3CCNC3)nc21,,ClCCl,,,,val
US20120065210A1,C=O.CC(C)(C)C[C@@H]1N[C@@H](C(=O)Nc2ccc(C(=O)O)c(C(F)(F)F)c2)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F>>CC(C)(C)C[C@@H]1N2CN(c3ccc(C(=O)O)c(C(F)(F)F)c3)C(=O)[C@H]2[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F,,O,,COCCOC,,val
US20030092910A1,COc1cc2ccccc2cc1NC(=O)Oc1ccccc1.Cc1cc(C)cc(N2CCNCC2)c1>>COc1cc2ccccc2cc1NC(=O)N1CCN(c2cc(C)cc(C)c2)CC1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20110207703A1,CCCCCCCCCCCC(C(C)CCCCCC)C(O)C(O)CO.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCCCCCCCCC(C(C)CCCCCC)[C@H](O)C(O)COC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,CC#N,CCN(CC)CC,,val
US20040082780A1,Cc1cnc2cccc(O)c2n1.FC(F)(F)c1ccc(-c2cc(Cl)ncn2)cc1>>Cc1cnc2cccc(Oc3cc(-c4ccc(C(F)(F)F)cc4)ncn3)c2n1,,CN(C)C=O,,[H-].[Na+],,val
US20020120144A1,COCCl.Cc1ccc(S(=O)(=O)n2c(-c3nc4cc(Cl)c(Cl)cc4[nH]3)cc3cc(C=O)ccc32)cc1>>COCn1c(-c2cc3cc(C=O)ccc3[nH]2)nc2cc(Cl)c(Cl)cc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US07687496B2,CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccccc1c2CC[Si](C)(C)CCCBr.c1nc[nH]n1>>CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccccc1c2CC[Si](C)(C)CCCn1cncn1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20030171360A1,O=S(=O)(Cl)c1cccc(C(F)(F)F)c1.O=c1[nH]c2ccccc2n1C1CCNCC1>>O=c1[nH]c2ccccc2n1C1CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1,,CN(C)C=O,ClCCl,,,val
US20160264548A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.NC(=O)c1cc(Cl)cnc1Oc1ccc(Oc2ccccc2)cc1>>CC(C)(C)OC(=O)N1CC=C(c2cnc(Oc3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2)CC1,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080027090A1,Nc1cc2c3c(c1)c1c(n3CCC2)CCCCC1.O=C(Cl)c1cccs1>>O=C(Nc1cc2c3c(c1)c1c(n3CCC2)CCCCC1)c1cccs1,,ClCCl,,,,val
US04469694,COc1cccccc1=O.FC(F)(F)c1cccc(N2CCNCC2)c1>>O=c1cccccc1N1CCN(c2cccc(C(F)(F)F)c2)CC1,,CO,,,,val
US05594004,COc1ccccc1.O=C(O)C(F)(F)F.O=C(O)COc1ccc(CCNC(=O)c2cc3c(s2)CCNC3)cc1OCC(=O)O>>CCOC(=O)COc1ccc(CCN)cc1.O=C([O-])C(F)(F)F,,COc1ccccc1,,O=C(O)C(F)(F)F,,val
US20060030613A1,CC(C)(C)c1cccc(O)c1.COC(Cl)Cl.O>>CC(C)(C)c1ccc(C=O)c(O)c1,,ClCCl,,Cl,,val
US20080280925A1,COc1ccccc1CNC(=O)c1cc(C(F)(F)F)nn1-c1cccc(CNC(=O)[C@H](C)NC(=O)OC(C)(C)C)n1>>COc1ccccc1CNC(=O)c1cc(C(F)(F)F)nn1-c1cccc(CNC(=O)[C@H](C)N)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05753663,COc1cc(N)cc(OC)c1OC.COc1cccc2c1CCc1cnc(SC)nc1-2>>COc1cccc2c1CCc1cnc(Nc3cc(OC)c(OC)c(OC)c3)nc1-2,,C1CCOC1,,O,[H-].[Na+],val
US20070117854A1,C=O.CC(C)(C)c1n[nH]cc1Br>>CC(C)(C)c1nn(CO)cc1Br,CCN(CC)CC,CC(C)=O,,,,val
US20090023724A1,CCN(CC)CC.C[Sn](C)(C)c1cnc2[nH]c(=O)n(CCC3CCOCC3)c2n1.Cc1ccccc1P(c1ccccc1C)c1ccccc1C>>O=c1[nH]c2ncc(-c3ccc(C4CCNC4)cc3)nc2n1CCC1CCOCC1,,CN(C)C=O,,Cl,,val
US20120220616A1,CI.COC(=O)c1sccc1O>>COC(=O)c1sccc1OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04141899,O=C=NC1CC1.c1nc2c([nH]1)CCNC2>>O=C(NC1CC1)N1CCc2[nH]cnc2C1,,C1COCCO1,CC#N,,,val
US20160152621A1,CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(-c2ccncc2)cc1Br.CC1(C)OB(c2ccsc2)OC1(C)C>>CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(-c2ccncc2)cc1-c1ccsc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050148627A1,CC#Cc1cc(OC(F)(F)F)cc2c1OC(C(F)(F)F)C(C(=O)O)=C2>>CCCc1cc(OC(F)(F)F)cc2c1OC(C(F)(F)F)C(C(=O)O)=C2,[Pd],CCO,,,,val
US20120172351A1,COC(=O)c1cccc(Nc2ccc(OC(F)(F)F)cc2NC(=O)[C@H]2CCCO2)c1C>>COC(=O)c1cccc(-n2c([C@H]3CCCO3)nc3cc(OC(F)(F)F)ccc32)c1C,,O,,,,val
US20110086898A1,BrCC1CC1.CCc1nn2c(-c3ccc(OC)cc3OC)coc2c1NC(=O)OC(C)(C)C>>CCc1nn2c(-c3ccc(OC)cc3OC)coc2c1N(CC1CC1)C(=O)OC(C)(C)C,,O,,CN(C)C=O,[H-].[Na+],val
US20050054658A1,CCCCOC(=O)[C@@H]1CC[C@H](CN=[N+]=[N-])CC1>>CCCCOC(=O)[C@@H]1CC[C@H](CN)CC1,[Pd],CCO,O,Cl,[H][H],val
US20120010190A1,CS(=O)(=O)CCN.Cn1cc(C(=O)CC(c2ccc(C(=O)O)cc2)c2ccc(Cl)cc2F)ccc1=O>>Cn1cc(C(=O)CC(c2ccc(C(=O)NCCS(C)(=O)=O)cc2)c2ccc(Cl)cc2F)ccc1=O,,C1CCOC1,,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,,val
US20120115869A1,C#CCOC.CCC(=O)N(Cc1cccc(I)c1)c1cccc(-c2nnn[nH]2)c1>>CCC(=O)N(Cc1cccc(C#CCOC)c1)c1cccc(-c2nnn[nH]2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,,CCN(CC)CC,,val
US20120142681A1,CCC(O)c1ccc2ncc(Cc3cc4cnn(C)c4cc3F)n2n1>>CCC(=O)c1ccc2ncc(Cc3cc4cnn(C)c4cc3F)n2n1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20110301161A1,CC(C)(C)n1c(-c2ccccc2-c2noc(C(Cl)(Cl)Cl)n2)nc2cc(-c3cnc(N)nc3)ccc21.[NH4+]>>CC(C)(C)n1c(-c2ccccc2-c2noc(N)n2)nc2cc(-c3cnc(N)nc3)ccc21,,CN(C)C=O,,O,,val
US20040116328A1,CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2nc(Oc3ccccc3C(N)=O)n(C)c(=O)c21>>CC#CCn1c(N2CCNCC2)nc2nc(Oc3ccccc3C(N)=O)n(C)c(=O)c21,,O=C(O)C(F)(F)F,,[Na+].[OH-],,val
US04255429,COc1cc2nc(Cl)nc(N)c2cc1OC.O=C1CC2(CCCC2)CC(=O)N1C1CCCNC1>>COc1cc2nc(N3CCCC(N4C(=O)CC5(CCCC5)CC4=O)C3)nc(N)c2cc1OC.Cl,,CC(C)CCO,,,,val
US20070270437A1,COC(=O)c1sc(Nc2cc(COC(=O)C(C)(C)C)ccc2[N+](=O)[O-])cc1O[C@H](C)c1ccccc1C(F)(F)F>>COC(=O)c1sc(Nc2cc(COC(=O)C(C)(C)C)ccc2N)cc1O[C@H](C)c1ccccc1C(F)(F)F,[Pt],CCOC(C)=O,,,,val
US20130131352A1,BrCc1ccccc1Br.CC(=O)n1ccc(O)n1>>Brc1ccccc1COc1cc[nH]n1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110021500A1,CCC1Cc2ccccc2N1C(=O)c1cc(Cl)ncn1.Nc1ccc2c(c1)CC1(C2)C(=O)Nc2ncccc21>>CCC1Cc2ccccc2N1C(=O)c1cc(Nc2ccc3c(c2)CC2(C3)C(=O)Nc3ncccc32)ncn1,,CC(C)O,,Cl,,val
US20030130518A1,CCOCc1nc2c(N)nc3ccccc3c2n1CCOCCN.O=C=NC1CCCCC1>>CCOCc1nc2c(N)nc3ccccc3c2n1CCOCCNC(=O)NC1CCCCC1,,ClCCl,,,,val
US20080194557A1,COc1ccc(F)c(C#N)c1.NN>>Nc1n[nH]c2ccccc12,,CCCCO,,O,,val
US04002691,C1=CC2C=CC1C2.C=CC[Mg]Br.O=O>>OCC1CC2C3C=CC(C3)C12,,CCOCC,O,[Cl-].[NH4+],,val
US20090203903A1,Cc1nc(C#Cc2ccc(Cl)nc2)cs1.N#Cc1ccccc1B(O)O>>Cc1nc(C#Cc2ccc(-c3ccccc3C#N)nc2)cs1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,O=C([O-])[O-].[K+].[K+],,val
US20120202785A1,C[C@H](N)c1nc2ncccc2n1-c1ccccc1.Clc1ncnc2c1ncn2C1CCCCO1>>CC(Nc1ncnc2[nH]cnc12)c1nc2ncccc2n1-c1ccccc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20100168418A1,Cc1cc(=O)n(CCN2CCC(N(Cc3ccc4c(c3)OCCO4)C(=O)OC(C)(C)C)CC2)c2cc(OC(F)F)ccc12.Cl>>Cc1cc(=O)n(CCN2CCC(NCc3ccc4c(c3)OCCO4)CC2)c2cc(OC(F)F)ccc12.Cl,,CCOC(C)=O,,CO,,val
US20090137609A1,CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(B3OC(C)(C)C(C)(C)O3)c(C)c2)cc1C)CC.COC(=O)Cc1cncc(Br)c1>>CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3cncc(CC(=O)OC)c3)c(C)c2)cc1C)CC,,CN(C)C=O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20060264460A1,N#Cc1cnc2c(Br)cc(NCc3cccnc3)cc2c1Nc1ccc(F)c(Cl)c1.OB(O)c1ccoc1>>N#Cc1cnc2c(-c3ccoc3)cc(NCc3cccnc3)cc2c1Nc1ccc(F)c(Cl)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US05783704,CN(C)C(=O)Cl.O=c1[nH]ncn1N=Cc1cccnc1>>CN(C)C(=O)n1ncn(N=Cc2cccnc2)c1=O,,c1ccncc1,,,,val
US20120010228A1,CC(C)(C)OC(=O)c1cc2ccccc2n1CCCCl.O=C(OCc1ccccc1)c1cccc(CN2CN(c3ccccc3)C3(CCNCC3)C2=O)c1>>CC(C)(C)OC(=O)c1cc2ccccc2n1CCCN1CCC2(CC1)C(=O)N(Cc1cccc(C(=O)OCc3ccccc3)c1)CN2c1ccccc1,,CCC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20080004271A1,NC(=O)c1sc2ncnc(-c3cccc(N)c3)c2c1N.Nc1ccncc1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>NC(=O)c1sc2ncnc(-c3cccc(NC(=O)Nc4ccncc4)c3)c2c1N,,C1CCOC1,,CCN(CC)CC,,val
US20150111870A1,COc1nc2ccc(I)cc2c(Cl)c1CC1CC1.Cc1ccc(C(=O)c2cnnn2C)c(C)n1>>COc1nc2ccc(C(O)(c3ccc(C)nc3C)c3cnnn3C)cc2c(Cl)c1CC1CC1,,C1CCOC1,,[Li]CCCC,,val
US04239901,CC(=O)Nc1ccc(CC(=O)O)cc1Br>>Nc1ccc(CC(=O)O)cc1Br,,Cl,,CC(=O)O,[Na+].[OH-],val
US20090264445A1,COC(C)(OC)OC.Nc1c(O)cccc1O>>Oc1cccc2ocnc12,O=S(=O)(O)O,,,Cl,,val
US20140243347A1,CCOC(=O)CC1CNC(=O)c2cc(-c3ccnc(N)n3)cn21>>Nc1nccc(-c2cc3n(c2)C(CC(=O)O)CNC3=O)n1,,C1CCOC1,O,[Li+].[OH-],,val
US06143751,CC(C)(C)[Si](C)(C)Cl.C[C@@H](OCc1ccccc1)C(O)C#Cc1cccnc1>>C[C@@H](OCc1ccccc1)C(C#Cc1cccnc1)O[Si](C)(C)C(C)(C)C,,CN(C)C=O,,O,c1c[nH]cn1,val
US20160002221A1,CC(O)c1ccc(Br)cc1.CI>>COC(C)c1ccc(Br)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20120184543A1,CO[C@H](CN1CCN(CC2CC2)CC1)CN(Cc1ccccc1)Cc1ccccc1>>CO[C@@H](CN)CN1CCN(CC2CC2)CC1,[Pd],CO,,[H][H],,val
US05597820,CC(C)I.COC(=O)c1ccc2c(c1)OC(C)(C)C(=O)N2>>COC(=O)c1ccc2c(c1)OC(C)(C)C(=O)N2C(C)C,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20160067208A1,CC1(C)OCC(CO)O1.COC(=O)CCCC(C)CCCC(C)CCCC(C)C>>CC(C)CCCC(C)CCCC(C)CCCC(=O)OCC1COC(C)(C)O1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150166564A1,CCOc1nn(-c2ccccc2)c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)c(F)c2)c1CC=O>>CCOc1nn(-c2ccccc2)c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)c(F)c2)c1CCO,,C1CCOC1,CCOC(C)=O,[BH4-].[Li+],,val
US05081135,CCOC(=O)C1CC(C)CC(O)(C(=O)OCC)N1C=O>>CC1CC(C(=O)O)N(C=O)C(O)(C(=O)O)C1,,CCO,,[Na+].[OH-],,val
US20080227839A1,CC(=O)OC(C)=O.C[C@@H](n1c(N)nc2ccc(C#Cc3ccccc3)cc21)C(C)(C)C>>CC(=O)Nc1nc2ccc(C#Cc3ccccc3)cc2n1[C@H](C)C(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20160237091A1,Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc4[nH]c(=O)c(C(C)c5ccccc5)cc4cc23)ccn1>>Cc1cc(-c2n[nH]c3cc4[nH]c(=O)c(C(C)c5ccccc5)cc4cc23)ccn1,,ClCCl,O=C(O)C(F)(F)F,,,val
US04521420,Nc1ccccc1C(=O)NO.O=C(Cl)c1ccccc1Cl>>O=c1c2ccccc2nc(-c2ccccc2Cl)n1O,,C1COCCO1,,,,val
US20110003787A1,CSc1cnc(N)cn1.Cl>>CSc1cnc(Cl)cn1,,O,,O=N[O-].[Na+],,val
US20050176701A1,Cc1cnc2nc(C=O)nn2c1.O=C1CC(=O)OC(CCc2ccc(O)c(CC(F)(F)F)c2)(C2CCCC2)C1>>Cc1cnc2nc(CC3=C(O)CC(CCc4ccc(O)c(CC(F)(F)F)c4)(C4CCCC4)OC3=O)nn2c1,,CO,,,,val
US20020132812A1,COc1cccc(/C(=C\C#N)c2ccccn2)c1>>COc1cccc(C(CC#N)c2ccccn2)c1,[Pd],CCO,,,,val
US20100056639A1,Cc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1cc(F)c(F)c(N)c1F.OO>>Cc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1cc(F)c(F)c([N+](=O)[O-])c1F,,ClC(Cl)Cl,,O,O=C(O)C(F)(F)F,val
US20100280268A1,COC(=O)c1cc(Sc2ccc([N+](=O)[O-])cc2)ccc1[N+](=O)[O-]>>COC(=O)c1cc(Sc2ccc(N)cc2)ccc1N,[Pd],C1CCOC1,CO,,,val
US20110224225A1,COc1cc(F)ccc1-c1ccnc(NC(=O)[C@@H]2CC[C@H](NC(=O)OC(C)(C)C)C2)c1>>COc1cc(F)ccc1-c1ccnc(NC(=O)[C@@H]2CC[C@H](N)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090023785A1,NC(=O)c1ccc(Oc2ccc3c(c2)CCCC3=O)cc1.NCc1ccccc1>>NC(=O)c1ccc(Oc2ccc3c(c2)CCCC3NCc2ccccc2)cc1,Cl[Ti](Cl)(Cl)Cl,C1CCOC1,,[Na+].[OH-],,val
US20020198388A1,CC(=O)Nc1cc(S(=O)(=O)Cl)ccc1F.CC(C)(CCC#N)CNC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12>>CC(=O)Nc1cc(S(=O)(=O)N(C[C@@H](O)[C@H](Cc2ccccc2)NC(=O)O[C@H]2CO[C@H]3OCC[C@@H]23)CC(C)(C)CCC#N)ccc1F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080300242A1,COc1cc(CCN2CCCCC2)c(F)cc1[N+](=O)[O-]>>COc1cc(CCN2CCCCC2)c(F)cc1N,,CCOC(C)=O,,,,val
US20160031829A1,CS(=O)(=O)c1cc(C#N)ccc1C(N)C1=C(Nc2ccnc(C(F)(F)F)c2)CCC1=O.O=C(n1ccnc1)n1ccnc1>>CS(=O)(=O)c1cc(C#N)ccc1C1NC(=O)N(c2ccnc(C(F)(F)F)c2)C2=C1C(=O)CC2,,CC#N,,CCN(CC)CC,Cl,val
US20100311777A1,COC(=O)Cc1cc(Br)c(C)cc1C.OB(O)C1CC1>>COC(=O)Cc1cc(C2CC2)c(C)cc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20130190307A1,CC(C)(C#N)c1ccc(N)cc1.O=[N+]([O-])c1nnc2ccc(Br)cc2c1Cl>>CC(C)(C#N)c1ccc(Nc2c([N+](=O)[O-])nnc3ccc(Br)cc23)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100204236A1,CCC(C)(C)Cc1c[nH]c(CCC(N)=S)n1.O=C(CBr)c1ccc(F)c(F)c1>>CCC(C)(C)Cc1cnc(CCc2nc(-c3ccc(F)c(F)c3)cs2)[nH]1,,C1COCCO1,CCO,,,val
US04452791,BrCCc1ccccc1.CCOP(Cl)OCC>>CCOP(CCc1ccccc1)OCC,,CCOCC,,[Mg],,val
US04161538,NO.O=C(O)Cc1ccc(CC2CCCCC2=O)cc1>>O=C(O)Cc1ccc(CC2CCCCC2=NO)cc1,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20160122345A1,CC(C)[C@H](NC(=O)OC(C)(C)C)c1ncc(Cl)cc1CO.CS(=O)(=O)Cl>>CC(C)[C@H](NC(=O)OC(C)(C)C)c1ncc(Cl)cc1COS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20150018547A1,COC(=O)CC(=O)CSc1cccc(OC)c1C>>COC(=O)Cc1csc2c(C)c(OC)ccc12,,CS(=O)(=O)O,,,,val
US20150105373A1,COCC(=O)c1ccc(OC(F)(F)F)cc1.NO>>COCC(=NO)c1ccc(OC(F)(F)F)cc1,,CCO,,CCN(CC)CC,Cl,val
US20080261969A1,CCOC(=O)c1[nH]ccc1N.Cc1ccc2[nH]c(Sc3ccc(C=O)o3)nc2c1.O=C1CCCC(=O)C1>>CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3cc(C)ccc3[nH]2)o1,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20030229066A1,COC(=O)CS.O=C(c1ccc(C(F)(F)F)cc1F)C1CCN(Cc2ccccc2)CC1>>COC(=O)c1sc2cc(C(F)(F)F)ccc2c1C1CCN(Cc2ccccc2)CC1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130109662A1,C=C1CC(=O)O1.CCCCNC>>CCCCN(C)C(=O)CC(C)=O,,CO,,,,val
US20150284370A1,C1CCNCC1.CCN(c1cc(-c2ccc(CO)nc2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1>>CCN(c1cc(-c2ccc(CN3CCCCC3)nc2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1,,ClCCl,,CCN(C(C)C)C(C)C,CS(=O)(=O)Cl,val
US20060173048A1,CCC(=O)CC.CCn1c(Br)nc(-c2ccncc2)c1-c1ccc(Cl)cc1>>CCn1c(C(O)(CC)CC)nc(-c2ccncc2)c1-c1ccc(Cl)cc1,,C1CCOC1,,,,val
US20160052939A1,CC(C)(C)OC(=O)N1C[C@H]2C[C@@H](Oc3ccc(Cl)cn3)[C@@H]1C2>>Clc1ccc(O[C@@H]2C[C@@H]3CN[C@H]2C3)nc1,,C1COCCO1,CCOC(C)=O,Cl,,val
US20100249095A1,CC(C)(C)OC(=O)N1CCC2(CCN(c3ccccn3)CC2)C1>>c1ccc(N2CCC3(CCNC3)CC2)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090163471A1,CC(=O)O.CNc1ccc(C(=O)OC)c(C)c1[N+](=O)[O-]>>COC(=O)c1ccc2c(ncn2C)c1C,[Pd],CCOC(C)=O,,,,val
US20030199440A1,CC(C)(C)OC(=O)CCN.O=S(=O)(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>CC(C)(C)OC(=O)CCNS(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1,,ClCCl,,CCN(CC)CC,Cl,val
US20150018332A1,CN(C)CC1(F)CNC1.O=C(O)/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1>>CN(C)CC1(F)CN(C(=O)/C=C\n2cnc(-c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C1,,ClCCl,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20160108040A1,CS(=O)(=O)Cl.C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cncc(OCCO)c4)c4ccccc43)cn12>>C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cncc(OCCOS(C)(=O)=O)c4)c4ccccc43)cn12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070219198A1,CC(=O)c1cccc(S(=O)(=O)N2CCN(c3ccc(F)cc3C(F)(F)F)C[C@H]2C)c1.C[Si](C)(C)C(F)(F)F>>C[C@@H]1CN(c2ccc(F)cc2C(F)(F)F)CCN1S(=O)(=O)c1cccc(C(C)(O)C(F)(F)F)c1,,O=C([O-])O,[Na+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130079313A1,CS(=O)(=O)Cl.O=Cc1ccc(OCC2CC2)c(O)c1>>CS(=O)(=O)Oc1cc(C=O)ccc1OCC1CC1,,ClCCl,,,,val
US20110201643A1,CC(=O)N1CCc2ccc(C(=O)NOC3CCCCO3)cc2C1>>CC(=O)N1CCc2ccc(C(=O)NO)cc2C1,,CO,,O,,val
US20060009456A1,C=CCOc1ccc(C(C)=O)c(C)c1C.CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2>>C=CCOc1ccc([C@H](C)N2C[C@@H]3C[C@H]2CN3C(=O)OC(C)(C)C)c(C)c1C,CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C,CCO,,[BH4-].[Na+],,val
US20090264431A1,CC(C)(C)OC(=O)N1C[C@H](NS(=O)(=O)c2cc(Cl)ccc2Cl)C[C@@H]1CN1C(=O)c2ccccc2C1=O>>CC(C)(C)OC(=O)N1C[C@H](NS(=O)(=O)c2cc(Cl)ccc2Cl)C[C@@H]1CN,,CCO,,NN,O,val
US20120329785A1,CN1CCN(c2ccc(N)cc2)CC1.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1>>COc1ccc2nc(Nc3ccc(N4CCN(C)CC4)cc3)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US20140309192A1,C1CNCCN1.O=[N+]([O-])c1ccc(Br)cc1F>>O=[N+]([O-])c1ccc(Br)cc1N1CCNCC1,,CC(C)O,,,,val
US20110143937A1,Cc1cc(O)c(C)cc1N.Cc1ccc(S(=O)(=O)c2nc(C3(c4ccc(Cl)cc4)CC3)ns2)cc1>>Cc1cc(Oc2nc(C3(c4ccc(Cl)cc4)CC3)ns2)c(C)cc1N,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060089355A1,CCCCNC(=O)COc1ccc(C(=O)NC[C@@H](C[C@H](NC(=O)OC(C)(C)C)[C@@H](O)C[C@H](C(=O)NCCCC)C(C)C)C(C)C)c(OCCCCOC)c1.Cl>>CCCCNC(=O)COc1ccc(C(=O)NC[C@@H](C[C@H](N)[C@@H](O)C[C@H](C(=O)NCCCC)C(C)C)C(C)C)c(OCCCCOC)c1.Cl,,C1COCCO1,,,,val
US07495007B2,C=C(C)C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Br)ccc12.OB(O)C1CC1>>C=C(C)C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(C3CC3)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20140018319A1,CC(C)(C)OC(=O)Nc1cc(C#N)cc(CN2CCN(C(=O)OC(C)(C)C)CC2)c1Cl>>N#Cc1cc(N)c(Cl)c(CN2CCNCC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100035883A1,CC(C)(C)OC(=O)NCCCC(=O)c1ccc(Br)cc1>>Brc1ccc(C2=NCCC2)cc1,,O=C(O)C(F)(F)F,,[Na+].[OH-],,val
US20060094767A1,Cc1ccc(S(=O)(=O)OCC2(C)CO2)cc1.Sc1nnnn1-c1ccccc1>>CC1(CSc2nnnn2-c2ccccc2)CO1,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US06610705B1,COc1ccc(C(c2ccc(O)c(C)c2)C2CCCc3ccccc32)cc1.ClCCN1CCCCC1>>COc1ccc(C(c2ccc(OCCN3CCCC3)c(C)c2)C2CCCc3ccccc32)cc1,,CC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090239864A1,COc1ccc(C#N)cc1[C@H]1CN(Cc2ccccc2)CCO1.ClCCCl>>COc1ccc(C#N)cc1[C@H]1CNCCO1.Cl,,ClCCCl,,CC(Cl)OC(=O)Cl,,val
US20160185779A1,O=C(O)CCc1ccccc1.c1ccc(-c2n[nH]c3c2CNCC3)cc1>>O=C(CCc1ccccc1)N1CCc2[nH]nc(-c3ccccc3)c2C1,,ClCCl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140148340A1,FC(F)(F)Oc1ccc(-n2ccc(Br)c2)cc1.O=Cc1ccc(B(O)O)cc1>>O=Cc1ccc(-c2ccn(-c3ccc(OC(F)(F)F)cc3)c2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20070099880A1,CC(=O)O[C@H]1CC[C@@]2(CO)C(=CC[C@@H]3[C@@H]2CC[C@]2(C)[C@@H](OC(C)=O)CC[C@@H]32)C1.CI>>COC[C@]12CC[C@H](OC(C)=O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](OC(C)=O)CC[C@@H]12,,CN(C)C=O,,[H-].[Na+],,val
US20090042892A1,ClI.Nc1ccc2c(c1)CN(C(=O)OCc1ccccc1)C2>>Nc1cc2c(cc1I)CN(C(=O)OCc1ccccc1)C2,,CO,ClCCl,O=C([O-])O.[Na+],,val
US05620974,COc1cc(C)c(N)c(Br)n1.O=C(Cl)c1cccnc1Cl>>COc1cc(C)c(NC(=O)c2cccnc2Cl)c(Br)n1,,ClCCl,,,,val
US20120322802A1,COC(=O)Cc1cccs1.COc1cc(OC)nc(S(C)(=O)=O)n1.O>>COC(=O)C(Oc1nc(OC)cc(OC)n1)c1cccs1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100035883A1,CCOC(=O)c1cccc2c1C(=O)C(O)(c1ccc(F)cc1)C(c1nccn1C)N2.NN>>Cn1ccnc1C1Nc2cccc3c(=O)[nH]nc(c23)C1(O)c1ccc(F)cc1,,CO,,O,,val
US20060189623A1,Fc1ccccn1.N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCNCC3)cc2C2=CCCCC2)n1.O=C(O)C(F)(F)F>>N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(c4ccccn4)CC3)cc2C2=CCCCC2)n1.O=C(O)C(F)(F)F,,O,,CC(=O)N(C)C,O=C([O-])[O-].[K+].[K+],val
US05110956,N#CCSCCc1ccc2c(c1)OCO2.O=C=O>>N#CC(SCCc1ccc2c(c1)OCO2)C(=O)O,,CCCCCC,CCOCC,O,[Li]CCCC,val
US20160159752A1,CC(C)(C)OC(=O)N(CCO)C[C@H](CCc1c(F)cccc1NC(=O)C(OCc1ccccc1)C(c1ccccc1)c1ccccc1)NS(=O)(=O)c1ccccc1>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccccc2)[C@@H](CCc2c(F)cccc2NC(=O)C(OCc2ccccc2)C(c2ccccc2)c2ccccc2)C1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20120283239A1,CC(C)(C)OC(=O)N1CCC(CCO)CC1.Oc1ncc(Br)cc1C(F)(F)F>>CC(C)(C)OC(=O)N1CCC(CCOc2ncc(Br)cc2C(F)(F)F)CC1,,C1COCCO1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020107257A1,CN[C@@H]1Cc2cccc3[nH]c(=S)n(c23)C1.O=C(O)/C=C\C(=O)O>>CN[C@@H]1Cc2cccc3[nH]c(=S)n(c23)C1.O=C(O)/C=C\C(=O)O,,ClCCl,,CO,,val
US20090197871A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1ccc(F)c(Br)c1>>CC(C)(C)OC(=O)NCc1ccc(F)c(Br)c1,,C1CCOC1,,[Na+].[OH-],,val
US20130029962A1,COCCN.O=Cc1ccc(N(Cc2ccccc2)Cc2ccccc2)cn1>>COCCNCc1ccc(N(Cc2ccccc2)Cc2ccccc2)cn1,CC(=O)O,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20110212962A1,CC(Oc1ccc([N+](=O)[O-])c2ccccc12)c1ccnc(N)c1>>CC(Oc1ccc(N)c2ccccc12)c1ccnc(N)c1,[Pt],CC(=O)O,CO,[H][H],,val
US20130065859A1,COC(=O)c1cnc(Cl)s1.Cc1ccccc1C1CCc2cc(O)ccc2O1>>COC(=O)c1cnc(Oc2ccc3c(c2)CCC(c2ccccc2C)O3)s1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US05994344,O=S(=O)(O)CCCN1CCOCC1.O=S(Cl)Cl>>Cl.O=S(=O)(Cl)CCCN1CCOCC1,,CN(C)C=O,,,,val
US05328909,CC(=O)Cl.CC(C)C[C@H](NC(=O)OCC1CCCCC1)C(=O)N[C@@H](C(C)C)[C@H](O)c1c(-c2ccccc2)c1=O>>CC(=O)O[C@H](c1c(-c2ccccc2)c1=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)OCC1CCCCC1)C(C)C,,CCN(CC)CC,ClCCl,Cl,,val
US20110172245A1,N#CC1(c2cccc(C(=O)O)c2)CC1.Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)[nH]c3c2)c1>>N#CC1(c2cccc(C(=O)Nc3cccc(Oc4ccc5nc(NC(=O)C6CC6)[nH]c5c4)c3)c2)CC1,CN(C)c1ccncc1,c1ccncc1,,CCN=C=NCCCN(C)C,Cl,val
US20100120741A1,NNc1nc2cc(Cl)ccc2nc1Cl.O=N[O-]>>Clc1ccc2nc(Cl)c3nnnn3c2c1,,O,,Cl,,val
US20160271270A1,C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)Nc1cc2c(c3ccccc13)[C@H](CCl)CN2C(=O)OC(C)(C)C.Cc1csc2c(OCc3ccccc3)cc3c(c12)[C@H](CCl)CN3C(=O)CCCC(=O)OC(C)(C)C>>Cc1csc2c(OCc3ccccc3)cc3c(c12)[C@H](CCl)CN3C(=O)CCCC(=O)N1C[C@@H](CCl)c2c1cc(NC(=O)[C@H](C)NC(=O)OCC1c3ccccc3-c3ccccc31)c1ccccc21,,ClCCl,O=C(O)C(F)(F)F,O=C(Cl)C(=O)Cl,,val
US20150299171A1,CC(C)(C)OC(=O)N1CCC[C@@H](n2nc(N)c(C#N)c2-c2ccc(Oc3ccccc3)cc2)C1.OO>>CC(C)(C)OC(=O)N1CCC[C@@H](n2nc(N)c(C(N)=O)c2-c2ccc(Oc3ccccc3)cc2)C1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100035865A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)[C@H]1CCNC[C@H]1c1ccccc1>>CCOC(=O)[C@H]1CCN(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1,,C1CCOC1,O,O=C([O-])[O-].[K+].[K+],,val
US20120088748A1,COC(=O)C1CCN(C[C@H]2OCCN(C(=O)OC(C)(C)C)C[C@H]2c2ccc(Cl)c(Cl)c2)CC1>>CC(C)(C)OC(=O)N1CCO[C@H](CN2CCC(C(=O)O)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1,,CCO,,O,[Na+].[OH-],val
US20090270436A1,CCOC(=O)c1cc(-c2nnn[nH]2)c2ccn(C3CC3)c2c1>>O=C(O)c1cc(-c2nnn[nH]2)c2ccn(C3CC3)c2c1,,CO,,Cl,[Na+].[OH-],val
US20140309192A1,CCCC(=O)Cl.O=C(Nc1ccc(Cl)cc1N1CCN(CCC(F)(F)F)CC1)c1ccc2c(c1)CNCC2>>CCCC(=O)N1CCc2ccc(C(=O)Nc3ccc(Cl)cc3N3CCN(CCC(F)(F)F)CC3)cc2C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130303507A1,N#CC1(CNc2cccc(-c3cc(N[C@@H]4CC[C@@H](N)CC4)ncc3Cl)n2)CCOCC1.OCCCBr>>N#CC1(CNc2cccc(-c3cc(N[C@@H]4CC[C@@H](NCCCO)CC4)ncc3Cl)n2)CCOCC1,,CS(C)=O,ClCCl,CCN(CC)CC,,val
US20100137313A1,COCCOc1ncc(-c2cnc(Nc3ccc(F)c(Cl)c3)nc2-n2nc(C(F)(F)F)cc2C)cc1C(=O)OC>>COCCOc1ncc(-c2cnc(Nc3ccc(F)c(Cl)c3)nc2-n2nc(C(F)(F)F)cc2C)cc1C(=O)O,,C1CCOC1,C1COCCO1,Cl,[Na+].[OH-],val
US20130143925A1,O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)CN2CCN(Cc3ccccc3)CC2)CC1>>O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)CN2CCNCC2)CC1,[Pd],CCO,,,,val
US20140094474A1,C[C@H](N)Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1.Cc1nc(C(=O)O)cn1C[C@@H](C)O>>Cc1nc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3)n2)cn1C[C@@H](C)O,,ClCCl,,CN(C)C=O,,val
US20100099695A1,CCCC[C@@H]1NC(=O)OCCCC=Cc2cccc(c2)CO[C@@H]2C[C@@H](C(=O)OC)N(C2)C1=O>>CCCC[C@@H]1NC(=O)OCCCC=Cc2cccc(c2)CO[C@@H]2C[C@@H](C(=O)O)N(C2)C1=O,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US20080200448A1,CC(=O)O.CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3)CC2)nc1CCl>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3)CC2)nc1COC(C)=O,,CC(C)=O,,[I-].[Na+],,val
US20070112000A1,CON(C)C(=O)[C@H]1CCCN(C(=O)c2ccc(F)cc2)[C@H]1C.Fc1ccc([Mg]Br)cc1>>C[C@H]1[C@@H](C(=O)c2ccc(F)cc2)CCCN1C(=O)c1ccc(F)cc1,,C1CCOC1,,CCOCC,,val
US20110130398A1,COc1cc(OCCO[Si](C)(C)C(C)(C)C)ccc1[N+](=O)[O-]>>COc1cc(OCCO[Si](C)(C)C(C)(C)C)ccc1N,[Pd],CCOC(C)=O,,,,val
US20110263594A1,O=[N+]([O-])c1ccc(Sc2nnc3ccc(-c4ccc(F)cc4)cn23)cc1>>Nc1ccc(Sc2nnc3ccc(-c4ccc(F)cc4)cn23)cc1,,CCO,,Cl,,val
US20110124640A1,Cc1c(C(N)=S)cccc1[N+](=O)[O-].NN>>Cc1c(C(=N)NN)cccc1[N+](=O)[O-],,CCO,,O,,val
US20050032786A1,COC(=O)c1ccccc1S.N#Cc1cccc(CN2C(=O)c3ccccc3C2=O)n1>>O=C1c2ccccc2C(=O)N1Cc1cccc(-c2nc(=O)c3ccccc3s2)n1,,Cc1ccccc1,,CCN(CC)CC,,val
US04794183,CCCCCCCCCCCCCCCCOC[C@@H]1OCC[C@H]1O.CCN(C(C)C)C(C)C.O=P1(Cl)OCCO1>>CCCCCCCCCCCCCCCCOC[C@@H]1OCC[C@H]1OP(=O)([O-])OCC[N+](C)(C)C,,ClCCCl,,,,val
US20140256768A1,CC(C)(C)OC(=O)n1ccc2cccnc21.CC(C)OB(OC(C)C)OC(C)C>>CC(C)(C)OC(=O)n1c(B(O)O)cc2cccnc21,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US04191770,CC(=O)Cl.ClCC1CNC(c2ccccc2)O1>>CC(=O)NCC(O)CCl,,ClC(Cl)Cl,c1ccncc1,Cl,,val
US05962450,C1CCNC1.O=C1c2c(Cl)cccc2-n2cnc(-c3nc(CCl)cs3)c2[C@@H]2CCCN12>>O=C1c2c(Cl)cccc2-n2cnc(-c3nc(CN4CCCC4)cs3)c2[C@@H]2CCCN12,,C1CCOC1,,,,val
US20120094972A1,CC1(C)CNc2cc(N3CCOCC3)ccc21.Cc1c(-c2cccnc2)nc2cc(F)ccc2c1Cl>>Cc1c(-c2cccnc2)nc2cc(F)ccc2c1N1CC(C)(C)c2ccc(N3CCOCC3)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20040186290A1,CCCS.Clc1cc(Br)cnc1Cl>>CCCSc1ncc(Br)cc1Cl,,CS(C)=O,,O,[Na+].[OH-],val
US20160083400A1,CC1(C(=O)NCC2=NNC3=N[C@@H](c4ccc(Cl)cc4)CCN3C2=O)SCCCS1>>CC1(c2ncc3c(=O)n4c(nn23)N[C@@H](c2ccc(Cl)cc2)CC4)SCCCS1,,O=P(Cl)(Cl)Cl,,,,val
US20110124626A1,NCCc1ccc2c(c1)CCN(C1CCC1)CC2.O=C(Cl)c1cccnc1>>O=C(NCCc1ccc2c(c1)CCN(C1CCC1)CC2)c1cccnc1,,c1ccncc1,,,,val
US20050014727A1,CCOP(=O)(CC#N)OCC.COc1ccc(C(=O)c2cc(OC)cc(OC)c2)cc1>>COc1ccc(C(=CC#N)c2cc(OC)cc(OC)c2)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05541324,CC(C)(N)CO.O=[N+]([O-])c1ccc(Cl)cc1Cl>>CC(C)(CO)Nc1cc(Cl)ccc1[N+](=O)[O-],,O,,,,val
US20060004013A1,COC(=O)C(c1ccc(F)cc1)N1CCC/C(=C\c2ccc(-n3cnc(C)c3)c(OC)c2)C1=O>>COc1cc(/C=C2\CCCN(C(C(=O)O)c3ccc(F)cc3)C2=O)ccc1-n1cnc(C)c1,,CO,,Cl,[Na+].[OH-],val
US20060025433A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CN)CC1.CCN(C(C)C)C(C)C.Fc1cnc(Cl)cc1Cl>>CC(C)(C)OC(=O)NC1CCC(CNc2nc(Cl)ncc2F)CC1,,CCO,,,,val
US04146715,C=O.CC(=O)OCCS.Cl>>CC(=O)OCCSCCl,,ClCCl,,[Ca+2].[Cl-].[Cl-],,val
US20050090509A1,CN.COc1ccc(CC(=O)O)c(Cl)c1>>CNC(=O)Cc1ccc(OC)cc1Cl,CN(C)C=O,ClCCl,,C1CCOC1,O=C(Cl)C(=O)Cl,val
US05385692,CCCCCCC(F)COS(=O)(=O)c1ccc(C)cc1.CCCCCCCCC1Cc2ccc(-c3ncc(O)cn3)cc2C1>>CCCCCCCCC1Cc2ccc(-c3ncc(OCC(F)CCCCCC)cn3)cc2C1,,CCCCO,,[K+].[OH-],,val
US20090163572A1,COc1cc(C=O)cc(O)c1OC.SCc1ccccc1S>>COc1cc(C2SCc3ccccc3S2)cc(O)c1OC,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2C(C)(C)C.CSCCCOS(=O)(=O)c1ccc(C)cc1>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCCSC)cc1CC2C(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020137974A1,C1CCNCC1.Clc1ccccc1>>c1ccc(N2CCCCC2)cc1,,Cc1ccccc1,,,,val
US20150291562A1,C=CC#N.OCCCCCO>>N#CCCOCCCCCO,,C1CCOC1,,[H-].[Na+],,val
US20110152318A1,CC(NC(=O)c1coc(Cl)n1)c1cc(F)c(NS(C)(=O)=O)c(F)c1.OB(O)c1ccc2ccccc2c1>>CC(NC(=O)c1coc(-c2ccc3ccccc3c2)n1)c1cc(F)c(NS(C)(=O)=O)c(F)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04066692,CCCCCC(O)CCCC(CCCCCCC(=O)OCC)C(=O)CO>>CCCCCC(O)CCCC(CCCCCCC(=O)O)C(=O)CO,,CO,O,Cl,[K+].[OH-],val
US20060264403A1,CC(C)(C)OC(=O)NC(CO)(CCc1ccc(OCc2ccccc2)cc1)COC(=O)c1ccccc1[N+](=O)[O-].COC(C)(C)OC>>CC(C)(C)OC(=O)N1C(CCc2ccc(OCc3ccccc3)cc2)(COC(=O)c2ccccc2[N+](=O)[O-])COC1(C)C,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080096938A1,CCCCCCCCOc1ccc(C(=O)NNC(=O)[C@]2(C)COC(C)(C)N2C(=O)OC(C)(C)C)cc1C(F)(F)F.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCCCCCCCOc1ccc(-c2nnc([C@@]3(C)COC(C)(C)N3C(=O)OC(C)(C)C)s2)cc1C(F)(F)F,,Cc1ccccc1,,,,val
US20100249085A1,BrCC1CCOCC1.N#Cc1ccc(O)cc1>>N#Cc1ccc(COC2CCOCC2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04413005,CCOC(=O)CNC(=O)CC.CNC(=O)Oc1cccc2c1OC(C)(C)C2.ClSCl>>CCOC(=O)CN(SN(C)C(=O)Oc1cccc2c1OC(C)(C)C2)C(=O)CC,,ClCCl,,CCN(CC)CC,,val
US04229459,CC(C)(C)C(=O)C(Cl)Oc1ccc(Cl)cc1.c1nc[nH]n1>>CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1cncn1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120309738A1,CNc1cc(N2CCC(C(F)(F)F)CC2)c(Cl)cc1N.O=C(NCc1ccc(F)c(N=C=S)c1)C1(C(F)(F)F)CC1>>Cn1c(Nc2cc(CNC(=O)C3(C(F)(F)F)CC3)ccc2F)nc2cc(Cl)c(N3CCC(C(F)(F)F)CC3)cc21,,CN(C)C=O,,CC(C)N=C=NC(C)C,,val
US20110245310A1,CC(C)C(=N)N.CCOC1=C(Br)C(=O)CCC1>>CC(C)c1nc2c([nH]1)CCCC2=O,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20110312945A1,C1CCNC1.CCOC(=O)Cn1c(C)c(Sc2ccc(Br)cc2S(=O)(=O)Cl)c2c1CC(C)(C)CC2=O>>CCOC(=O)Cn1c(C)c(Sc2ccc(Br)cc2S(=O)(=O)N2CCCC2)c2c1CC(C)(C)CC2=O,,ClCCl,,,,val
US20110183960A1,COC(=O)c1ccc(F)cc1Cl.COc1ccc(CC(=O)O)cc1>>COc1ccc(CC(=O)c2ccc(F)cc2Cl)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US04910202,CCCN(CCN)CCN.Nc1nc(N)c(C(=O)n2ccnc2)nc1Cl>>CCCN(CCN)CCNC(=O)c1nc(Cl)c(N)nc1N,,C1CCOC1,,,,val
US04107326,CSC(=NCc1ccccc1)NCc1ccccc1.I.NN>>I.NNC(=NCc1ccccc1)NCc1ccccc1,,CCO,,O,,val
US05330998,Cc1oc(-c2ccccc2)nc1CSc1ccc(C=O)cc1.O=C1CSC(=O)N1>>Cc1oc(-c2ccccc2)nc1CSc1ccc(C=C2SC(=O)NC2=O)cc1,,CCO,CCOCC,C1CCNCC1,,val
US20120184553A1,CC(C)c1ccc(OCc2ccccc2)c(C(=O)O)c1.Nc1cccnc1>>CC(C)c1ccc(OCc2ccccc2)c(C(=O)Nc2cccnc2)c1,,CN(C)C=O,O,ClCCCl,On1nnc2ccccc21,val
US20150210682A1,CCOC=O.COc1ccc(CC(C)N)c(Cl)c1OC>>COc1ccc(CC(C)NC=O)c(Cl)c1OC,,C1COCCO1,,,,val
US20030149060A1,CCn1cnc2c(N)nc(NCc3ccccc3)nc21.O=C1CCC(=O)N1Br>>CCn1c(Br)nc2c(N)nc(NCc3ccccc3)nc21,,CN(C)C=O,,,,val
US20060058542A1,C(=Cc1ccccc1)c1ccccc1.CC(Cl)Cl>>CC1(Cl)CC1(c1ccccc1)c1ccccc1,,CCOCC,O,CCCCCC,[Li]CCCC,val
US20100204196A1,C1CCOC1.COc1ccc2c(c1)CCNC2=O>>COc1ccc2c(c1)CCN(C)C2=O,,[Cl-],[NH4+],[H-].[Na+],,val
US20040049039A1,COC(OC)N(C)C.Cc1nc2ccsc2c(=O)n1-c1ccccc1Cl>>CN(C)C=Cc1nc2ccsc2c(=O)n1-c1ccccc1Cl,,CN(C)C=O,,,,val
US20130336920A1,CC(C)(C)OC(=O)CCSCc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)O)ccn2)c1.NCc1cccc(C(F)(F)F)c1>>CC(C)(C)OC(=O)CCSCc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US04833270,CCOC=C(C(=O)OCC)C(=O)c1cc(F)c(F)cc1Cl.NC1CC1>>CCOC(=O)C(=CNC1CC1)C(=O)c1cc(F)c(F)cc1Cl,,CCO,,,,val
US20130109718A1,Cc1ccccc1C(CC(=O)[C@@H]1CC[C@@H](OC2CCCCO2)CC1)c1ccc(Br)cc1>>Cc1ccccc1C(CC(=O)[C@@H]1CC[C@@H](O)CC1)c1ccc(Br)cc1,,CO,,O=C(O)C(F)(F)F,,val
US20070117854A1,FC(Cl)(Cl)Sc1cn(CCl)c2ccccc12.N#CC(C#N)CCC(F)(F)F>>N#CC(C#N)(CCC(F)(F)F)Cn1cc(SC(F)(Cl)Cl)c2ccccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20020072516A1,COC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O>>COC(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)O,[Pd],CO,,,,val
US20120149711A1,C[C@H]1CC[C@@H](CN)N(C(=O)OC(C)(C)C)C1.Fc1cc(C(F)(F)F)ccn1>>C[C@H]1CC[C@@H](CNc2cc(C(F)(F)F)ccn2)N(C(=O)OC(C)(C)C)C1,,CCOCC,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20090012103A1,CCOC(=O)/C(C#N)=C/c1ccccc1.O=C1CCCC(=O)C1>>CCOC(=O)C1=C(N)OC2=C(C(=O)CCC2)C1c1ccccc1,,CCO,,,,val
US20130102576A1,COC(=O)Cn1ccc2cc(NS(C)(=O)=O)ccc21.ClCCN1CCOCC1>>COC(=O)Cn1ccc2cc(N(CCN3CCOCC3)S(C)(=O)=O)ccc21,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20070088163A1,CCCCOC(=O)N1C(=O)CC(=O)C1C(C)C>>CC(C)[C@H]1NC(=O)CC1=O,,ClCCl,O=C(O)C(F)(F)F,,,val
US05665718,CCCN.O=C1c2cc(Cl)ccc2-n2cnc(-c3noc(CCl)n3)c2[C@@H]2CCN12>>CCCNCc1nc(-c2ncn3c2[C@@H]2CCN2C(=O)c2cc(Cl)ccc2-3)no1,,CN(C)C=O,,,,val
US20100179147A1,COc1cc(C=O)cc(OC)c1OC.Cc1ccc(N)c(NC(=O)c2ccccc2)c1>>COc1cc(/C=N/c2ccc(C)cc2NC(=O)c2ccccc2)cc(OC)c1OC,,CO,,,,val
US04140768,CS(=O)(=O)Cl.OC1=CC=CNN1O>>CS(=O)(=O)Oc1ccc(=O)[nH]n1,,O,,[K+].[OH-],,val
US20160207928A1,N#Cc1ccccc1Nc1nc2cnc(-c3cccc(C(=O)O)c3)cn2n1.NC1CC1>>N#Cc1ccccc1Nc1nc2cnc(-c3cccc(C(=O)NC4CC4)c3)cn2n1,,C1CCOC1,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130210806A1,FC(F)(F)c1c(CCc2ccccc2)cc2c3c1ccn3CCNC2.O=C(O)CCC(F)(F)F>>O=C(CC(F)(F)F)C1Cn2ccc3c(C(F)(F)F)c(CCc4ccccc4)cc(c32)CN1,,C1CCOC1,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160186094A1,CC(C)(C)[Si](C)(C)OCCBr.CCCCCCCCCCCCC(C)c1ccc(CO)cc1>>CCCCCCCCCCCCC(C)c1ccc(COCCO[Si](C)(C)C(C)(C)C)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20110112293A1,O=[N+]([O-])c1nccn1CC(CO)OC1CCCCO1.[N-]=[N+]=NCCCS(=O)(=O)Cl>>[N-]=[N+]=NCCCS(=O)(=O)OCC(Cn1ccnc1[N+](=O)[O-])OC1CCCCO1,,ClCCl,,CCN(CC)CC,O,val
US04814341,CCCCCCNC(=N)NC(N)=S.CN(C)C(=O)c1ccc(C(=O)CBr)o1>>Br.CCCCCCNC(=N)Nc1nc(-c2ccc(C(=O)N(C)C)o2)cs1,,CC(C)=O,,,,val
US20150057265A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@H]1CC(c2ccncc2[N+](=O)[O-])=C[C@@H](N=[N+]=[N-])[C@@]12CO2>>C[C@H]1C[C@@H](c2ccncc2N)C[C@@H](NC(=O)OC(C)(C)C)[C@]1(C)O,[Pd],CCO,,c1ccncc1,,val
US20070060754A1,CCCc1nc2c(N)nc3cc(OCCCN)ccc3c2n1CC(C)C.O=S(=O)(Cl)CCCCl>>CCCc1nc2c(N)nc3cc(OCCCN4CCCS4(=O)=O)ccc3c2n1CC(C)C,,ClC(Cl)Cl,,C1CCC2=NCCCN2CC1,O,val
US06071903,CC(C)(C)OC(=O)[C@@H](N)CO.COc1ccc(S(=O)(=O)Cl)cc1>>COc1ccc(S(=O)(=O)N[C@@H](CO)C(=O)OC(C)(C)C)cc1,,ClCCl,,CCN(CC)CC,,val
US20160264554A1,Cc1c(-c2nc(N[C@@H]3CCC[C@H](NC(=O)OCc4ccccc4)C3)ncc2Cl)c2ccccc2n1S(=O)(=O)c1ccccc1>>Cc1c(-c2nc(N[C@@H]3CCC[C@H](N)C3)ncc2Cl)c2ccccc2n1S(=O)(=O)c1ccccc1,[Pd],CO,,,,val
US20070135631A1,CCOC(=O)CCCCCO.O=C(NC1CCCC1)NC(Cc1ccc(O)cc1)(c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)F)c1>>CCOC(=O)CCCCCOc1ccc(CC(NC(=O)NC2CCCC2)(c2cccc(OC(F)(F)F)c2)c2cccc(OC(F)(F)F)c2)cc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090156607A1,Cc1ccc(S(=O)(=O)Cl)cc1.Cc1n[nH]c(C)c1I>>Cc1ccc(S(=O)(=O)n2nc(C)c(I)c2C)cc1,,ClCCl,,c1ccncc1,,val
US20030220325A1,C1CNCCN1.CS(=O)(=O)O.O=S(=O)(c1ccccc1)c1ccc(Br)c2ccccc12>>CS(=O)(=O)O.O=S(=O)(c1ccccc1)c1ccc(N2CCNCC2)c2ccccc12,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040077654A1,C1CCNCCNC1.COc1ccc(Br)c(OC)c1>>COc1ccc(N2CCCCNCC2)c(OC)c1,,C1CCOC1,,Cl,[Li]CCCC,val
US20050070605A1,CC(C)n1c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)O)c(-c2ccc(F)cc2)c2ccccc21>>CC(C)n1c(/C=C/[C@@H]2C[C@@H](O)CC(=O)O2)c(-c2ccc(F)cc2)c2ccccc21,,CCOC(C)=O,,Cl,[Na],val
US20040058905A1,C[C@H]1CCC[C@@H](C)N1CCCN.ClCCl.O=C(O)[C@@H]1CCCCN1c1nc2ccccc2o1>>Cc1ccc2oc(N3CCCC[C@H]3C(=O)NCCCN3[C@@H](C)CCC[C@H]3C)nc2c1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US05736534,CCCCOc1cc2ncnc(Cl)c2cc1OC.Clc1ccc2c(c1)NCC2>>CCCCOc1cc2ncnc(N3CCc4ccc(Cl)cc43)c2cc1OC,,CC(C)O,,,,val
US07728014B2,C=CN1CCCC1.CCOC(=O)c1nnc(-c2ccccc2)c(-c2ccc(CC)cc2)n1>>CCOC(=O)c1ccc(-c2ccccc2)c(-c2ccc(CC)cc2)n1,,ClC(Cl)Cl,,,,val
US20030187007A1,CC(=O)c1cc(Br)ccc1O.CI>>COc1ccc(Br)cc1C(C)=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06255496B1,CCCCCCCCCCCCNCCOc1ccc(I)cc1.CCOC(=O)CCC=O>>CCCCCCCCCCCCN(CCCC(=O)OCC)CCOc1ccc(I)cc1,,CCOC(C)=O,CO,[BH3-]C#N.[Na+],,val
US20120214762A1,Nc1ccnc(Cl)n1.O=[N+]([O-])c1cc(F)c(Br)cc1F>>O=[N+]([O-])c1cc(F)c(Br)cc1Nc1ccnc(Cl)n1,,C1CCOC1,CO,O,[H-].[Na+],val
US20100280030A1,CC(=O)c1ccc2[nH]c(=O)oc2c1>>CC(O)c1ccc2[nH]c(=O)oc2c1,[Pd],CO,,,,val
US20110118262A1,CO.Cc1cc(O)c(I)cc1C(=O)O>>COC(=O)c1cc(I)c(O)cc1C,,CO,,CC(=O)Cl,,val
US20150291572A1,CC(C)(C)[Si](C)(C)OCC1CC(O)CCO1.CS(=O)(=O)Cl>>CC(C)(C)[Si](C)(C)OCC1CC(OS(C)(=O)=O)CCO1,,ClCCl,,,,val
US20020006948A1,N#CCCCCCOc1ccc2nc(-c3ccccc3)n(-c3ccccc3)c2c1.OO>>NC(=O)CCCCCOc1ccc2nc(-c3ccccc3)n(-c3ccccc3)c2c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20110201625A1,C[N+](C)(CCNC(=O)c1nc(Cl)c(N)nc1N)CCN1C(=O)c2ccccc2C1=O.[Br-]>>C[N+](C)(CCN)CCNC(=O)c1nc(Cl)c(N)nc1N.[Br-],,CCO,,NN,O,val
US04588732,CCOC(=O)c1ccc(-c2cccc(C#N)n2)cc1>>CCOC(=O)c1ccc(-c2cccc(CN)n2)cc1,[Pd],CO,,Cl,[H][H],val
US20140148433A1,COC(=O)c1cnc(-c2nn(Cc3ccccc3F)c3ncccc23)nc1Cl.N=CN>>O=c1nc[nH]c2nc(-c3nn(Cc4ccccc4F)c4ncccc34)ncc12,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20150152113A1,COc1cccc(F)c1C1CC1CNc1cnnc(NNC(=O)CC2CC2)c1Cl>>COc1cccc(F)c1C1CC1CNc1cnn2c(CC3CC3)nnc2c1Cl,,CC#N,,O=P(Cl)(Cl)Cl,,val
US05446153,CC(=O)Cl.CCCCNc1cc(C)nc(N(Cc2ccccc2)Cc2ccccc2)c1N>>CCCCn1c(C)nc2c(N(Cc3ccccc3)Cc3ccccc3)nc(C)cc21,,Cc1ccccc1,,O=P(Cl)(Cl)Cl,,val
US20060217372A1,COc1ccc2c(c1)CCN(C(=O)C(F)(F)F)CC2>>O=C(N1CCc2ccc(O)cc2CC1)C(F)(F)F,,ClCCl,,BrB(Br)Br,,val
US20110288116A1,CC(=O)OC1CCN(C(=O)C(NC(=O)OC(C)(C)C)C2CCCCC2)C1Cc1c(Br)[nH]c2ccccc12>>CC(=O)OC1CCN(C(=O)C(N)C2CCCCC2)C1Cc1c(Br)[nH]c2ccccc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100113410A1,COc1c(C)cnc(Cn2nc(CC(O)C#N)c3c(Cl)nc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nc32)c1C.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1c(C)cnc(Cn2nc(CC(C#N)OS(=O)(=O)c3ccc(C)cc3)c3c(Cl)nc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nc32)c1C,CN(C)c1ccncc1,ClC(Cl)Cl,,CCN(CC)CC,ClCCl,val
US20090312383A1,CC=C(CC)c1ccc(C(F)(F)F)c2[nH]c(=O)n(C)c12>>CCC(CC)c1ccc(C(F)(F)F)c2[nH]c(=O)n(C)c12,[Pd],CC(=O)O,,[H][H],,val
US05175166,CI.c1ncc(C2OCCO2)cn1>>C[n+]1cncc(C2OCCO2)c1.[I-],,CC#N,,,,val
US20160106754A1,CC(=O)NN1C(=O)CC(=O)CC1c1ccccn1.COc1cc(SSc2cc(OC)c(Cl)cc2N)c(N)cc1Cl>>COc1cc2c(cc1Cl)NC1=C(S2)C(=O)N(NC(C)=O)C(c2ccccn2)C1,CCN(CC)CC,CCO,,,,val
US05470834,CC(C)CBr.CCOC(=O)CC(=O)OCC>>CCOC(=O)C(CC(C)C)C(=O)OCC,,CCO,,C,C[O-].[Na+],val
US20120122888A1,C=C[Mg]Br.N#CC(C#N)=C1CCCCC1>>C=CC1(C(C#N)C#N)CCCCC1,,C1CCOC1,,,,val
US20040014766A1,Cn1cc(C(=O)O)cn1.Nc1ccc(Cc2nc3c([nH]2)c(=O)n(Cc2ccccc2F)c(=O)n3CC2CC2)cc1>>Cn1cc(C(=O)Nc2ccc(Cc3nc4c([nH]3)c(=O)n(Cc3ccccc3F)c(=O)n4CC3CC3)cc2)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US06124341,Cc1cc(C)c(N)c(C)c1.O=C(Br)CBr>>Cc1cc(C)c(NC(=O)CBr)c(C)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080280933A1,Cn1c(CO)nc2cccc(Br)c21>>Cn1c(C=O)nc2cccc(Br)c21,O=[Mn]=O,ClCCl,,,,val
US20130023502A1,CC(=O)N(C(C)=O)c1c([N+](=O)[O-])cc([N+](=O)[O-])cc1C(F)(F)F>>Cc1nc2cc(N)cc(C(F)(F)F)c2[nH]1,[Pd],CC(=O)O,,[H][H],,val
US20070142452A1,FC1(F)CNC1.O=C1Cc2c(n(Cc3cccc4ccccc34)c3ccc(F)cc23)C(=O)O1>>O=C(O)c1c(CC(=O)N2CC(F)(F)C2)c2cc(F)ccc2n1Cc1cccc2ccccc12,,CCN(CC)CC,,Cl,,val
US20030032834A1,NCCC(c1ccccc1)c1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(NCCC(c1ccccc1)c1ccccc1)C(F)(F)F,,ClCCl,,Cl,c1ccncc1,val
US20050182096A1,O=S(Cl)Cl.OCc1cccc(C(F)(F)F)n1>>FC(F)(F)c1cccc(CCl)n1,,ClCCl,,,,val
US20040106616A1,CC(C)(C)c1ccc(Nc2nncc3cc(Br)ccc23)cc1.OB(O)c1ccccc1C(F)(F)F>>CC(C)(C)c1ccc(Nc2nncc3cc(-c4ccccc4C(F)(F)F)ccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100331365A1,CCOC(=O)Cl.CCOC(=O)c1cc2c(s1)CCc1ccccc1C2=C1CCN(C)CC1>>CCOC(=O)c1cc2c(s1)CCc1ccccc1C2=C1CCN(C(=O)OCC)CC1,,CC(Cl)Cl,,,,val
US20150018373A1,Cc1c2cc(-n3ccc(O)cc3=O)ccc2nn1C.OCc1csc(C(F)(F)F)c1>>Cc1c2cc(-n3ccc(OCc4csc(C(F)(F)F)c4)cc3=O)ccc2nn1C,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120046292A1,COC(=O)C[C@@H]1CC[C@@H](c2ccc(O)cc2)CC1.O=S(=O)(Cl)C(F)(F)F>>COC(=O)C[C@@H]1CC[C@@H](c2ccc(OS(=O)(=O)C(F)(F)F)cc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20120122709A1,Cc1ccc(S(=O)(=O)N2CCCC2C(=O)Nc2ccccc2)cc1F.ClCn1nnc2ccccc21>>Cc1ccc(S(=O)(=O)N2CCCC2C(=O)N(Cn2nnc3ccccc32)c2ccccc2)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US20090306102A1,O=C(c1ccccc1)c1cccnc1-c1nc2ccccc2c(=O)[nH]1.O=P(Cl)(Cl)Cl>>O=C(c1ccccc1)c1cccnc1-c1nc(Cl)c2ccccc2n1,,c1ccccc1,,CN(C)c1ccccc1,,val
US20080318975A1,CCOC(=O)c1cc2c(OC)cccc2cc1[N+](=O)[O-]>>CCOC(=O)c1cc2c(OC)cccc2cc1N,[Pd],CCO,,[H][H],,val
US04902698,COC(=O)CCCc1ccc(N)cn1.O=S(=O)(Cl)c1ccccc1>>COC(=O)CCCc1ccc(NS(=O)(=O)c2ccccc2)cn1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20150094297A1,COc1cc(OCc2csc(C3CCNCC3)n2)c2cc(-c3cn4nc(OC)sc4n3)oc2c1.O=C(O)c1ccccc1>>COc1cc(OCc2csc(C3CCN(C(=O)c4ccccc4)CC3)n2)c2cc(-c3cn4nc(OC)sc4n3)oc2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040048868A1,Cc1cc(N)c(N)cc1C.O=Cc1n[nH]c2cccc(F)c12>>Cc1cc2nc(-c3n[nH]c4cccc(F)c34)[nH]c2cc1C,,CCOC(C)=O,CN(C)C=O,,,val
US20120028941A1,CN(CCOc1ccccc1C1(N)CC1)C(=O)OCc1ccccc1.COC(=O)c1cc(F)c(C)c(-n2cc(Br)nc(Br)c2=O)c1>>COC(=O)c1cc(F)c(C)c(-n2cc(Br)nc(NC3(c4ccccc4OCCNCC(=O)OCc4ccccc4)CC3)c2=O)c1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20090247746A1,CCOC(=O)CC(=O)Cl.CN(c1cccc2cc(C(=O)NN)[nH]c12)S(=O)(=O)c1cccs1>>CCOC(=O)CC(=O)NNC(=O)c1cc2cccc(N(C)S(=O)(=O)c3cccs3)c2[nH]1,,CC(=O)N(C)C,,O,,val
US04593102,O=S(=O)(c1ccccc1)N1CCCCC1CCl.Sc1ccc(Cl)cc1>>O=S(=O)(c1ccccc1)N1CCCCC1CSc1ccc(Cl)cc1,,CN(C)C=O,,[Na+].[OH-],,val
US20130035377A1,CCOC(=O)C(Cc1ccccc1)NC(=O)NCc1ccccc1>>O=C(NCc1ccccc1)NC(Cc1ccccc1)C(=O)O,,CCO,,[Li+].[OH-],,val
US20080146625A1,CS(=O)(=O)c1ccc(/C(=N\OC2CCCC2)C(=O)O)cc1.Nc1nc2ccccc2s1>>CS(=O)(=O)c1ccc(/C(=N\OC2CCCC2)C(=O)Nc2nc3ccccc3s2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130274253A1,CCOC(=O)Cc1nc(N2CCOCC2)cc(=O)n1-c1ccccc1.c1ccc2c(c1)CCN2>>O=C(Cc1nc(N2CCOCC2)cc(=O)n1-c1ccccc1)N1CCc2ccccc21,,C1CCOC1,Cc1ccccc1,C[Al](C)C,,val
US05721245,Cn1cc(C2=C(c3c4n(c5ccccc35)CC(NC(=O)OC(C)(C)C)CC4)C(=O)OC2=O)c2ccccc21.N>>Cn1cc(C2=C(c3c4n(c5ccccc35)CC(NC(=O)OC(C)(C)C)CC4)C(=O)NC2=O)c2ccccc21,,N,,CN(C)C=O,,val
US20110250136A1,Nc1ccc(F)cc1S.O=Cc1ccc([N+](=O)[O-])cc1>>O=[N+]([O-])c1ccc(-c2nc3ccc(F)cc3s2)cc1,,CS(C)=O,,,,val
US20030036557A1,CS(=O)(=O)c1ccc(-n2cc(C=O)nc2-c2ccc(Cl)cc2)cc1.c1ccncc1>>CS(=O)(=O)c1ccc(-n2cc(C#N)nc2-c2ccc(Cl)cc2)cc1,,CCO,,,,val
US06936602B1,CCOCCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3)cc1.CS(=O)(=O)OS(C)(=O)=O>>CCOCCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3S(C)(=O)=O)cc1,,C1CCOC1,,c1ccncc1,,val
US04746352,CC(C)OC(=O)c1cc(-n2c(=O)[nH]c3c(c2=O)CCC3)c(Cl)cc1Cl.COS(=O)(=O)OC>>CC(C)OC(=O)c1cc(-n2c(=O)c3c(n(C)c2=O)CCC3)c(Cl)cc1Cl,,CC(C)O,,[Na],,val
US05102897,CC(C)(C)c1cc(SCCC(=O)NN)cc(C(C)(C)C)c1O.S=C(Cl)Cl>>CC(C)(C)c1cc(SCCc2n[nH]c(=S)o2)cc(C(C)(C)C)c1O,,C1CCOC1,,CCOC(C)=O,O=C([O-])O.[Na+],val
US20040132694A1,NC(=O)c1c(Cl)ccc([N+](=O)[O-])c1Cl.O>>NC(=O)c1c(Cl)ccc([N+](=O)[O-])c1O,,C1CCOC1,,[H-].[Na+],,val
US20160009744A1,CC(C)[Si](O[C@H]1C[C@H](Nc2ncncc2C(=O)c2cc(Cc3cccc(C#C[Si](C)(C)C)c3)cs2)C[C@@H]1CO)(C(C)C)C(C)C>>C#Cc1cccc(Cc2csc(C(=O)c3cncnc3N[C@@H]3C[C@H](CO)[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)C3)c2)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20140213591A1,NCC1=CCOc2ccc(F)cc21>>NCC1CCOc2ccc(F)cc21,[Ni],CC(=O)O,CO,Cl,,val
US04067723,O=C(c1ccco1)c1ccccc1Cl>>OC(c1ccco1)c1ccccc1Cl,,CO,O,[Na+].[OH-],,val
US04111923,COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)OCc1ccccc1.Cl>>COC(=O)[C@H](CC(C)C)NC(=O)[C@H](N)CC(C)C.Cl,[Pd],CO,,[H][H],,val
US06395731B1,CC(C)(C)OC(=O)Nc1nc(-c2ccc(C(=O)N3CCN(S(=O)(=O)c4ccc5cc(Br)ccc5c4)CC3)cc2)c[nH]1>>Nc1nc(-c2ccc(C(=O)N3CCN(S(=O)(=O)c4ccc5cc(Br)ccc5c4)CC3)cc2)c[nH]1,,C1COCCO1,ClCCl,Cl,,val
US20090186879A1,COc1ccc(N2CCCn3c2nc2c(Cl)ccc(C(O)C4CC4)c23)c(C)n1.OCC(F)F>>COc1ccc(N2CCCn3c2nc2c(Cl)ccc(C(OCC(F)F)C4CC4)c23)c(C)n1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20050038081A1,Cc1ccc(C(=O)Nc2cccc(N(C)C)c2)cc1NC(=O)c1ccc(OCc2ccccc2)cc1>>Cc1ccc(C(=O)Nc2cccc(N(C)C)c2)cc1NC(=O)c1ccc(O)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US20130041007A1,NNc1cc(Cl)ccc1Cl.O=C1CCCCC1=O>>O=C1CCCc2c1[nH]c1c(Cl)ccc(Cl)c21,,CO,,Cl,,val
US20150126492A1,CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)CC1CCO.CI>>COCCC1CN(C(=O)OCc2ccccc2)CCN1C(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US04348399,CCO.O=C(O)CCCc1ccc([N+](=O)[O-])cc1>>CCOC(=O)CCCc1ccc(N)cc1,[Pd],,,[H][H],,val
US20050054645A1,CC(C)(C)OC(=O)NCCN.O=Cc1ccc(Cl)c(Cl)c1>>CC(C)(C)OC(=O)NCCNCc1ccc(Cl)c(Cl)c1,,ClC(Cl)Cl,,CC(=O)O,O=C([O-])O.[Na+],val
US20160185764A1,CCOP(=O)(Cc1ccc(Br)cn1)OCC.C[C@H]1[C@H](C=O)[C@@H]2[C@@H](C)OC(=O)[C@@H]2CC1(F)F>>C[C@H]1[C@H](/C=C/c2ccc(Br)cn2)[C@@H]2[C@@H](C)OC(=O)[C@@H]2CC1(F)F,CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20110319277A1,O=C1CCC(CCCCNC(=O)OCc2ccccc2)(N2C(=O)c3cccc([N+](=O)[O-])c3C2=O)C(=O)N1>>Nc1cccc2c1C(=O)N(C1(CCCCNC(=O)OCc3ccccc3)CCC(=O)NC1=O)C2=O,[Ni],CCO,,[H][H],,val
US04772600,CNC.O=C(O)Cn1c(-c2cccc(Br)c2)nc2cccnc21>>CN(C)C(=O)Cn1c(-c2cccc(Br)c2)nc2cccnc21,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20120122780A1,COC(=O)CSc1scnc1-c1ccc(C)cc1Cl>>Cc1ccc(-c2ncsc2SCC(=O)O)c(Cl)c1,,CCOC(C)=O,CS(C)=O,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20010051631A1,Cc1nc2cccc3n(CCC(C)NS(=O)(=O)CC(F)(F)F)c(=O)c1n23.Cl>>Cc1nc2cccc3n(CCC(C)NS(=O)(=O)CC(F)(F)F)c(=O)c1n23.Cl,,CO,,,,val
US20120316212A1,O=C(CCNC(=O)OCc1ccccc1)N[C@H](CO)Cc1cnc[nH]1>>NCCC(=O)N[C@H](CO)Cc1cnc[nH]1,[Pd],CO,O,,,val
US20070197604A1,NC(=O)c1ccc(Br)cc1.O=C(CCl)CCl>>ClCc1coc(-c2ccc(Br)cc2)n1,,CC(C)O,,,,val
US20040248951A1,CCOC(=O)COc1ccccc1C#CCOC>>CCOC(=O)COc1ccccc1CCCOC,[Pd],CCOC(C)=O,,,,val
US20120190124A1,CCCN.CN1C(=O)C=C(Br)C1=O>>CCCNC1=CC(=O)N(C)C1=O,,CO,,CC(=O)[O-].[Na+],,val
US20100022769A1,NCCN1CCCC1.O=Cc1ccc(C=O)cc1>>O=Cc1ccc(CNCCN2CCCC2)cc1,,CO,O,Cl,[Na+].[OH-],val
US20150126490A1,COC(=O)[C@@H]1C=C(c2ccc(N)nc2)CN1C(=O)OC(C)(C)C>>COC(=O)[C@@H]1C[C@H](c2ccc(N)nc2)CN1C(=O)OC(C)(C)C,[Pd],CO,,,,val
US06710055B2,CCOC(=O)CCN(C(=O)c1ccc(NC)c(N)c1)c1ccccn1.N#Cc1ccc(NCC(=O)O)cc1>>CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C#N)cc1)n2C)c1ccccn1,,CO,ClCCl,,,val
US04540699,CN(C)Cc1ccnc(CSCCN)c1.Cn1ccc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)cc1=O>>CN(C)Cc1ccnc(CSCCNc2ncc(Cc3ccn(C)c(=O)c3)c(=O)[nH]2)c1,,CCO,,c1ccncc1,,val
US20130217680A1,CC(C)(C)OC(=O)N1CCN(C2CC2c2ccc3c(c2)COC3=O)CC1>>O=C1OCc2cc(C3CC3N3CCNCC3)ccc21,,ClCCl,,C1COCCO1,Cl,val
US20120088755A1,O=C(Nc1c(Cl)cc(O)cc1[N+](=O)[O-])C1CCOCC1>>Nc1cc(O)cc(Cl)c1NC(=O)C1CCOCC1,[Ni],CCOC(C)=O,,[H][H],,val
US20090192138A1,COC(=O)c1c(N2CCN(C(=O)OC(C)(C)C)CC2)n(COCC[Si](C)(C)C)c2c(=O)n(COCC[Si](C)(C)C)cnc12>>COC(=O)c1c(N2CCNCC2)[nH]c2c(=O)[nH]cnc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100234365A1,ClC(Cl)(Oc1ccccc1)Oc1ccccc1.NS(N)(=O)=O>>NS(=O)(=O)N=C(Oc1ccccc1)Oc1ccccc1,,CC#N,,,,val
US20080214448A1,COC(=O)CCCCc1nc(-c2ccccc2NC(C)=O)co1>>CC(=O)Nc1ccccc1-c1coc(CCCCC(=O)O)n1,,CCO,,C1CCOC1,[Na+].[OH-],val
US04933355,C=CCNc1nc(C(=O)OCC)cs1>>C=CCNc1nc(CO)cs1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06057357,CN(C(=O)Cc1cccc2occc12)C(CC1CCC(O[Si](C)(C)C(C)(C)C)C1)c1cccc(OCC(=O)OC(C)(C)C)c1>>CN(C(=O)Cc1cccc2occc12)C(CC1CCC(O)C1)c1cccc(OCC(=O)OC(C)(C)C)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US07635779B2,O=c1cc(-c2cc(OCc3ccccc3)cc(OCc3ccccc3)c2)oc2cc(OCC3CO3)ccc12.c1ccc(N2CCNCC2)cc1>>O=c1cc(-c2cc(OCc3ccccc3)cc(OCc3ccccc3)c2)oc2cc(OCC(O)CN3CCN(c4ccccc4)CC3)ccc12,,CO,,,,val
US20150111914A1,COc1ccc(COCc2cnc3oc(C(=O)Nc4ncccc4Br)cc3c2)cc1.C[Si](C)(C)CCOCCl>>COc1ccc(COCc2cnc3oc(C(=O)N(COCC[Si](C)(C)C)c4ncccc4Br)cc3c2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110281842A1,COCOC1(c2ncc(-c3c(Cl)cnc4c3cc(-c3ccc(CN5CCC(F)CC5)c(F)c3)n4S(=O)(=O)c3ccc(C)cc3)s2)CCC1>>Cc1ccc(S(=O)(=O)n2c(-c3ccc(CN4CCC(F)CC4)c(F)c3)cc3c(-c4cnc(C5(O)CCC5)s4)c(Cl)cnc32)cc1,,CO,,Cl,,val
US07122666B2,CC(C(=O)Cl)C(=O)Cl.CCN(CC)CC.ClCCl.O=C([O-])O>>CO[C@H]1C[C@H]2CC(=O)CCN2C1,,ClCCl,,Cl,,val
US20100173944A1,CCCOc1ccnc(COC(C)=O)c1C>>CCCOc1ccnc(CO)c1C,,Cc1ccccc1,,[Na+].[OH-],,val
US20090264406A1,CC(c1cc2cccnc2cc1F)c1cnc2ccc(Cl)nn12.CC1(C)OB(c2cnn(CCOC3CCCCO3)c2)OC1(C)C>>CC(c1cc2cccnc2cc1F)c1cnc2ccc(-c3cnn(CCOC4CCCCO4)c3)nn12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20100016272A1,CI.O=Cc1[nH]c(-c2ccccc2)nc1Cl>>Cn1c(-c2ccccc2)nc(Cl)c1C=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160096829A1,CS(=O)(=O)Cl.OCC1C(c2ccc(Oc3ccc(Cl)cc3)cc2)=NOC12CCCCC2>>CS(=O)(=O)OCC1C(c2ccc(Oc3ccc(Cl)cc3)cc2)=NOC12CCCCC2,,ClCCl,,CCN(CC)CC,O,val
US04062862,COC=CCc1ccccc1.O=C(OO)c1cccc(Cl)c1>>COC=CCC1=CC2OC2C=C1,,ClC(Cl)Cl,,,,val
US20090004209A1,COC(=O)c1cccc(OCc2cccc(Cl)c2)c1C(=O)OC>>O=C(O)c1cccc(OCc2cccc(Cl)c2)c1C(=O)O,,[Na+],[OH-],,,val
US05747498,C#Cc1cccc(Nc2ncnc3ccc(N)cc23)c1.CS(=O)(=O)Cl>>C#Cc1cccc(Nc2ncnc3ccc(NS(C)(=O)=O)cc23)c1,,ClCCCl,,c1ccncc1,,val
US04393245,CC(=O)C1=CCCCCCCCCCC1>>CC(O)C1=CCCCCCCCCCC1,,CCO,,[BH4-].[Na+],,val
US20050148643A1,C[C@H](O)C(=O)O.Nc1ccccc1N>>C[C@H](O)c1nc2ccccc2[nH]1,,Cl,,N,,val
US20130225600A1,COC(=O)c1scc(Br)c1C.Nc1c(F)cccc1F>>Cc1c(Br)csc1C(=O)Nc1c(F)cccc1F,,ClCCl,,C[Al](C)C,,val
US20050272744A1,CCOC(=O)c1ccc(N2CCC(Cc3ccccc3F)(OC)CC2)cc1>>COC1(Cc2ccccc2F)CCN(c2ccc(C(=O)O)cc2)CC1,,C1COCCO1,,Cl,[Na+].[OH-],val
US20050267018A1,CC(C)(C)OC(=O)N[C@H]1CCCCCC=C[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2CC2)NC(=O)[C@@H]2C[C@@H](N)CN2C1=O.O=C(Cl)c1sc2ccccc2c1Cl>>CC(C)(C)OC(=O)N[C@H]1CCCCCC=C[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2CC2)NC(=O)[C@@H]2C[C@@H](NC(=O)c3sc4ccccc4c3Cl)CN2C1=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140142083A1,CC=O.CCc1c(NC2CCOCC2)cc(Cl)cc1C(=O)OC>>CCc1c(C(=O)OC)cc(Cl)cc1N(CC)C1CCOCC1,,ClCCCl,O,CC(=O)O,O=C([O-])O.[Na+],val
US20060142265A1,CCCOc1c(CO)cccc1C(C)C>>CCCOc1c(C=O)cccc1C(C)C,O=[Mn]=O,c1ccccc1,,,,val
US20160016948A1,CO[C@@H]1CCNC[C@H]1N=[N+]=[N-].Cc1nc2cnc(Nc3ccnc(Cl)n3)cc2n1C(C)C>>CO[C@@H]1CCN(c2nccc(Nc3cc4c(cn3)nc(C)n4C(C)C)n2)C[C@H]1N=[N+]=[N-],,CC(C)O,,CCN(CC)CC,,val
US20060094707A1,CC(C)(C)C(=O)Cl.Nc1ncccc1C=O>>CC(C)(C)C(=O)Nc1ncccc1C=O,,ClCCl,,CCN(CC)CC,,val
US04035369,C=C(C)n1c(=O)n(CCCCl)c2ccccc21.O=C(c1ccc(F)cc1)C1CCNCC1>>O=C(c1ccc(F)cc1)C1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1,,CC(=O)CC(C)C,,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20060252812A1,CCCCCN1C(=O)C(=O)c2ccccc21.OCc1cc2c(cc1Br)OCO2>>CCCCCN1C(=O)C(O)(c2cc3c(cc2CO)OCO3)c2ccccc21,,C1CCOC1,,[Li]CCCC,,val
US20050215605A1,N#CC(NC(=O)C1SCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1)c1ccccc1.NO>>N/C(=N\O)[C@H](NC(=O)C1SCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1)c1ccccc1,,CCO,,CCN(CC)CC,Cl,val
US20060160864A1,CCCCOCCOc1ccc(-c2ccc(N3CCCCC3)c(/C=C(\C)C(=O)O)c2)cc1.CCCn1cncc1C[S@](=O)c1ccc(N)cc1>>CCCCOCCOc1ccc(-c2ccc(N3CCCCC3)c(/C=C(\C)C(=O)Nc3ccc([S@@](=O)Cc4cncn4CCC)cc3)c2)cc1,CN(C)C=O,C1CCOC1,O,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US06063810,CS(=O)(=O)Cl.Cc1oc2c(CCO)cccc2c1C>>Cc1oc2c(CCS(C)(=O)=O)cccc2c1C,,O,,CCN(CC)CC,CCOCC,val
US05276186,N#CN.Nc1ccccc1.O=C([O-])O>>N=C(N)Nc1ccccc1.O=C(O)O,,O,,Cl,,val
US20030055076A1,COC(=O)[C@H](Cc1ccc(OCCN2c3ccccc3Oc3ccccc32)cc1)Nc1ccccc1C(=O)c1ccccc1>>O=C(c1ccccc1)c1ccccc1N[C@@H](Cc1ccc(OCCN2c3ccccc3Oc3ccccc32)cc1)C(=O)O,,CCO,,[Na+].[OH-],,val
US20090181942A1,COc1cccc(C(=O)c2cc(Cl)ccc2F)c1OC.Clc1nc[nH]c1Cl>>COc1cccc(C(=O)c2cc(Cl)ccc2-n2cnc(Cl)c2Cl)c1OC,,CS(C)=O,,CCOC(C)=O,[H-].[Na+],val
US20100168094A1,COC(=O)Oc1cc([N+](=O)[O-])ccc1OC(F)(F)F>>COC(=O)Oc1cc(N)ccc1OC(F)(F)F,[Pd],CCOC(C)=O,,,,val
US04772600,CCOC(=O)CNc1ncccc1NC(=O)c1ccccn1>>CCOC(=O)Cn1c(-c2ccccn2)nc2cccnc21,,ClCCl,,C,,val
US20030069239A1,CN1CCNCC1.Cc1ccc(NC(=O)c2ccc(CCl)cc2)cc1Nc1cc(C(F)(F)F)nc(-c2ccncc2)n1>>Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1cc(C(F)(F)F)nc(-c2ccncc2)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20050171109A1,COc1c(C)cccc1C(C)(C)CC(O)(C=O)C(F)(F)F.Cn1ncc2c(N)cccc2c1=O>>COc1c(C)ccc2c1C(C)(C)CC(O)(C(F)(F)F)C2Nc1cccc2c(=O)n(C)ncc12,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US04554351,CC(C)C[C@@H](C(=O)N[C@H](C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)Cc1ccccc1)C(C)C)N(C)C(=O)OC(C)(C)C>>CN[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)Cc1ccccc1)C(C)C,,O=C(O)C(F)(F)F,,,,val
US20090298823A1,Cc1cc2c(NC3CCC3)nc(Cl)nc2[nH]1.Nc1ccc2cn[nH]c2c1>>Cc1cc2c(NC3CCC3)nc(Nc3ccc4cn[nH]c4c3)nc2[nH]1,,CCCCO,,C[Si](C)(C)Cl,,val
US05834463,BrCc1ccccc1.O=C1Nc2ccccc2N=C2CCCCC12>>O=C1C2CCCCC2=Nc2ccccc2N1Cc1ccccc1,,CCCCCC,CCO,,,val
US20130261123A1,COC(=O)C1CCN(c2ncc3cc(O)ccc3n2)CC1>>O=C(O)C1CCN(c2ncc3cc(O)ccc3n2)CC1,,CCOC(C)=O,CO,Cl,[Na+].[OH-],val
US20120088765A1,CI.COc1ccc(CSc2nc(Cl)c3nc[nH]c3n2)cc1[N+](=O)[O-]>>COc1ccc(CSc2nc(Cl)c3ncn(C)c3n2)cc1[N+](=O)[O-],,CN(C)C=O,,O,[H-].[Na+],val
US20150057260A1,COCC(=O)Nc1cc(F)cnc1Br>>COCCNc1cc(F)cnc1Br,,C1CCOC1,,B,,val
US05455252,O=Cc1cc(-c2cccc(Cl)c2)c2ncccc2c1.[Li]C>>CC(O)c1cc(-c2cccc(Cl)c2)c2ncccc2c1,,C1CCOC1,CCOCC,[Cl-].[NH4+],,val
US20090023707A1,Cc1oc(-c2ccc(Cn3cnc4ccccc43)cc2)nc1CO.O=S(Cl)Cl>>Cc1oc(-c2ccc(Cn3cnc4ccccc43)cc2)nc1CCl,,ClCCl,,,,val
US20120258950A1,CC(C)n1cc(C(=O)c2cncc(NC(=O)C(OC3CCCCO3)c3ccccc3)c2)c2cncnc21>>CC(C)n1cc(C(=O)c2cncc(NC(=O)C(O)c3ccccc3)c2)c2cncnc21,,C1COCCO1,,Cl,,val
US20150284395A1,N#Cc1cnn2c(=O)cc(-c3ccc4c(c3)OCO4)[nH]c12.O>>NC(=O)c1cnn2c(=O)cc(-c3ccc4c(c3)OCO4)[nH]c12,,CS(C)=O,O,[Na+].[OH-],,val
US20050032786A1,C[S-].N#Cc1cc(Cl)ccn1>>CSc1ccnc(C#N)c1,,C1CCOC1,,CCOC(C)=O,O,val
US20040082570A1,CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2c1c(=O)n(CCc1ccccc1)c(=O)n2CC(=O)OCC>>CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2c1c(=O)n(CCc1ccccc1)c(=O)n2CC(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20100298221A1,Cc1ccc(-c2ccc(C(=O)OC(C)(C)C)c(Cl)n2)cc1F.Oc1ccc(Br)cc1F>>Cc1ccc(-c2ccc(C(=O)OC(C)(C)C)c(Oc3ccc(Br)cc3F)n2)cc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05434154,CCOC(=O)N1CCNCC1.O=[N+]([O-])c1cnccc1Cl>>CCOC(=O)N1CCN(c2ccncc2[N+](=O)[O-])CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20070032478A1,CCn1nc(C)cc1C(=O)Nc1cccc(C(=O)c2ccc3c(c2)C(=CO)C(=O)N3)c1.Nc1cccc(O)c1>>CCn1nc(C)cc1C(=O)Nc1cccc(C(=O)c2ccc3c(c2)C(=CNc2cccc(O)c2)C(=O)N3)c1,,C1CCOC1,,,,val
US20060211720A1,Brc1ccccc1-c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.CCc1cc(C=O)c(F)c(O[Si](C)(C)C(C)(C)C)c1>>CCc1cc(O[Si](C)(C)C(C)(C)C)c(F)c(C(O)c2nc(-c3ccccc3Br)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US05256679,CSC(=N[N+](=O)[O-])N(C)C(=O)OC(C)Cl.NCc1cnc(Cl)s1>>CC(Cl)OC(=O)N(C)C(=N[N+](=O)[O-])NCc1cnc(Cl)s1,,ClC(Cl)Cl,,,,val
US05935908,COC(=O)C(=NO)c1ccccc1C.FC(F)Cl>>COC(=O)C(=NOC(F)F)c1ccccc1C,,COCCOC,,CC(C)(C)[O-].[K+],,val
US20030220272A1,O=C/C=C/c1ccc(-c2cccnn2)cc1>>OC/C=C/c1ccc(-c2cccnn2)cc1,,CCO,,[BH4-].[Na+],,val
US20100004238A1,Nc1ccc(Oc2cccc3ncccc23)c(Cl)c1.O=C(OCCn1ccc2ncnc(Cl)c21)c1ccccc1>>OCCn1ccc2ncnc(Nc3ccc(Oc4cccc5ncccc45)c(Cl)c3)c21,,CC(C)O,,Cl,c1ccncc1,val
US20040127538A1,CC(C)(C)OC(=O)n1nc(-c2cccc(F)c2)c2cc(C=O)ccc21.CCOC(=O)CP(=O)(OCC)OCC>>CCOC(=O)/C=C/c1ccc2c(c1)c(-c1cccc(F)c1)nn2C(=O)OC(C)(C)C,,CN(C)C=O,,O,[H-].[Na+],val
US20020028832A1,CC(=O)c1ccc(OCc2ccccc2)c(C(N)=O)c1>>NC(=O)c1cc(C2CO2)ccc1OCc1ccccc1,,ClC(Cl)Cl,,BrBr,,val
US20160016948A1,CN(C)/C=C/c1c[n+]([O-])c(Br)cc1[N+](=O)[O-]>>Brc1cc2[nH]ccc2cn1,[Fe],CC(=O)O,,,,val
US20100113438A1,CS(=O)(=O)OCc1ccc(C(=O)/C=C/c2ccc(/C=C/C(=O)NOC3CCCCO3)cc2)cc1.c1ccc(CN2CCNCC2)cc1>>O=C(/C=C/c1ccc(/C=C/C(=O)c2ccc(CN3CCN(Cc4ccccc4)CC3)cc2)cc1)NO,,CN(C)C=O,O,,,val
US20100016319A1,CS(=O)(=O)CCO.N#Cc1cc(C(F)(F)F)ccc1F>>NCc1cc(C(F)(F)F)ccc1O,,CN(C)C=O,,Cl,[H-].[Na+],val
US20100204285A1,Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2cccc3sc(Cl)nc23)c1>>Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2cccc3scnc23)c1,[Pd],CO,,,,val
US20150322024A1,O=C1c2ccccc2C(=O)N1CCCN1CCCCC1>>NCCCN1CCCCC1,,CCO,,NN,O,val
US20070219210A1,CCOC(=O)C(=O)CC(=O)c1ccc(C)cn1.COc1ccc(NN)cn1>>CCOC(=O)c1cc(-c2ccc(C)cn2)n(-c2ccc(OC)nc2)n1,,CCO,CCOC(C)=O,CC(=O)O,O=C([O-])O.[Na+],val
US04656167,C=O.COc1cccc2c1C[C@H]1NCCO[C@@H]1C2>>COc1cccc2c1C[C@@H]1[C@@H](C2)OCCN1C,[Pd],CO,,[H][H],,val
US20160194350A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.O=C[C@@H](O)[C@H](O)[C@H](O)CO>>CC(C)(C)[Si](OC[C@H]1O[C@@H](O)[C@@H](O)C1O)(c1ccccc1)c1ccccc1,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20060235031A1,CS(=O)(=O)OS(C)(=O)=O.NCC1CC(c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(N)nccn23)C1>>CS(=O)(=O)NC[C@@H]1C[C@H](c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(N)nccn23)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040209897A1,CI.CN(C)C=O.Nc1ccc(I)cc1C(=O)O>>CNc1ccc(I)cc1C(=O)OC,,CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06498172B1,COC(=O)CCc1cccc(CN(CC=Cc2cc(Cl)cc(Cl)c2)S(=O)(=O)c2ccccc2)c1>>COC(=O)CCc1cccc(CN(CCCc2cc(Cl)cc(Cl)c2)S(=O)(=O)c2ccccc2)c1,O=[Pt]=O,CO,,,,val
US04876366,CC(C)(C)[Si](C)(C)Oc1ccc(CC(=O)O)cc1.CI>>CC(C(=O)O)c1ccc(O[Si](C)(C)C(C)(C)C)cc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US05536737,COC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSCN1C(=O)OCc1ccccc1>>O=C(O)[C@@H]1CCCN1C(=O)[C@@H]1CSCN1C(=O)OCc1ccccc1,,CO,,[Na+].[OH-],,val
US20100068301A1,COc1ccc(-c2ccc(CO)cc2)cn1.CS(=O)(=O)Cl>>COc1ccc(-c2ccc(COS(C)(=O)=O)cc2)cn1,,ClCCl,,CCN(CC)CC,,val
US20080312226A1,N=C(N)c1cccnc1.SC(Cl)(Cl)Cl>>Clc1nc(-c2cccnc2)ns1,,ClCCl,O,Cl,[Na+].[OH-],val
US20160229816A1,N#Cc1cccc(CBr)c1.OCC1CCCCC1>>N#Cc1cccc(COCC2CCCCC2)c1,,CN(C)C=O,,O,[H-].[Na+],val
US04208430,Clc1cccc(CBr)c1Cl.NC(N)=S>>N=C(N)SCc1cccc(Cl)c1Cl,,CCO,,,,val
US05084463,CN(CCCOc1ccc([N+](=O)[O-])cc1)Cc1ccc2cc([N+](=O)[O-])ccc2n1>>CN(CCCOc1ccc(N)cc1)Cc1ccc2cc(N)ccc2n1,O=[Pt]=O,CCO,,,,val
US20110313176A1,COc1cccc2c1CC[C@H](N)C2.Cc1ccc(S(=O)(=O)OCCc2cccs2)cc1.Cl>>COc1cccc2c1CC[C@H](NCCc1cccs1)C2.Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US08669249B2,COC(=O)COc1ccc(C=O)cc1[N+](=O)[O-]>>O=Cc1ccc2c(c1)NC(=O)CO2,[Fe],CC(=O)O,O,,,val
US04588746,C=C(Cc1ccccc1)C(=O)OC.CNC>>COC(=O)C(Cc1ccccc1)CN(C)C,,CO,,,,val
US20120214837A1,COc1ccc2nc(NC(C)C)c(CO)cc2c1.O=S(Cl)Cl>>COc1ccc2nc(NC(C)C)c(CCl)cc2c1.Cl,,ClCCl,,,,val
US07094789B2,COc1ccc(C(=O)O[C@@H]2CC[C@H](NC(=O)OC(C)(C)C)CC2)cc1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](O)CC1,,CO,,CCOC(C)=O,[Na+].[OH-],val
US05482913,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Oc1ccc(Sc2ccc(O)cc2)cc1>>CC(C)(C)OC(=O)OC(C)(C)C.Oc1ccc(Sc2ccc(O)cc2)cc1,,CCOC(C)=O,,c1ccncc1,,val
US20040267028A1,N#CC(CC(=O)c1ccc(Cl)cc1)C(=O)NC1CCCCC1.Nc1ccccc1Cl>>Nc1c(C(=O)NC2CCCCC2)cc(-c2ccc(Cl)cc2)n1-c1ccccc1Cl,,CCO,,Cl,,val
US20140051676A1,COC(=O)c1ccc(COCC(F)(F)F)cc1>>O=C(O)c1ccc(COCC(F)(F)F)cc1,,CO,,C1CCOC1,[Na+].[OH-],val
US20100075948A1,CCOC(=O)CC(C)(C)C(C)C>>CC(C)C(C)(C)CCO,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050080124A1,COc1ccc(N)cc1-c1c(Br)cnn1C.O=C=Nc1ccc(F)c(F)c1>>COc1ccc(NC(=O)Nc2ccc(F)c(F)c2)cc1-c1c(Br)cnn1C,,ClCCl,,,,val
US20070027178A1,Cl.NNc1ccc(Br)cc1I.O=C1CCNCC1>>Brc1cc(I)c2[nH]c3c(c2c1)CNCC3.Cl,,CC(C)O,,O,,val
US20050014727A1,COc1cc(OC)cc(C(O)c2ccc([N+](=O)[O-])c(OC)c2)c1>>COc1cc(OC)cc(C(=O)c2ccc([N+](=O)[O-])c(OC)c2)c1,O=[Mn]=O,ClCCl,,,,val
US20070179122A1,CC(C)(C)OC(=O)CCNC(=O)c1ccc(Cl)s1>>O=C(O)CCNC(=O)c1ccc(Cl)s1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080146569A1,N#Cc1cccc(-c2ccc(C(=O)O)cn2)c1.NC1CCN(CC(F)(F)F)CC1>>N#Cc1cccc(-c2ccc(C(=O)NC3CCN(CC(F)(F)F)CC3)cn2)c1,,CN(C)C=O,,,,val
US20020103141A1,CCOC(=O)/C=C/C(F)(F)F.CSc1ccc(O)c(C=O)c1>>CCOC(=O)C1=Cc2cc(SC)ccc2OC1C(F)(F)F,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04053606,C=Cc1cnc(C)c(O)c1CSC(=O)c1ccccc1>>C=Cc1cnc(C)c(O)c1CS,,C1CCOC1,,Cl,[Na+].[OH-],val
US20070203227A1,COc1cc2c(=O)c(-c3ccc(O)cc3)coc2cc1O>>COc1cc2c(cc1O)OCC(c1ccc(O)cc1)C2,[Pd],CCO,,,,val
US04254127,NC(N)=O.Nc1cc(Cl)c(Cl)cc1NCCO>>O=c1[nH]c2cc(Cl)c(Cl)cc2n1CCO,,O,,,,val
US20110076292A1,COC(=O)COc1cc2c(cn1)-c1nc(-c3ncnn3C(C)C)cn1CCO2.N>>CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(OCC(N)=O)cc1OCC2,,CO,,,,val
US20140275133A1,C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)NCC(=O)c2ccccc2)C1=O>>C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(c2ncc(-c3ccccc3)o2)C1=O,,O=C([O-])O,[Na+],O=S(=O)(O)O,,val
US05576321,Clc1ccc2c(C3=CCNCC3)c[nH]c2c1Cl.c1cc(OC[C@@H]2CO2)c2cc[nH]c2c1>>O[C@H](COc1cccc2[nH]ccc12)CN1CC=C(c2c[nH]c3c(Cl)c(Cl)ccc23)CC1,,CS(C)=O,,,,val
US06057325,CCOC(=O)N1CCc2[nH]c3ccccc3c2C1>>CCOC(=O)N1CC[C@H]2Nc3ccccc3[C@H]2C1,[Ni],CO,N,,,val
US20040147580A1,CN.O=Cc1cc2ccccc2o1>>CNCc1cc2ccccc2o1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20100035902A1,CC(=O)C1=C(C)Nc2nc[nH]c(=O)c2C1c1cccc2c(=O)cc(C)oc12.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(=O)C1=C(C)Nc2ncnc(OS(=O)(=O)C(F)(F)F)c2C1c1cccc2c(=O)cc(C)oc12,,c1ccncc1,,,,val
US20070049537A1,CC(=O)OC[C@H]1O[C@](O)(c2ccc(Cl)c(Cc3ccc(OC4(C(=O)O)CCCC4)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@](O)(c2ccc(Cl)c(Cc3ccc(OC4(CO)CCCC4)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20040138277A1,CCOC(=O)C(C)Br.Oc1ccc2c(c1)OCO2>>CCOC(=O)C(C)Oc1ccc2c(c1)OCO2,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4cocn4)nc(Cl)c3n2)cc1.Nc1ccc2c(c1)NC(=O)CC2>>O=C1CCc2ccc(Nc3nc(-c4cocn4)nc4cn[nH]c34)cc2N1,C1COCCO1,CO,,Cl,,val
US04153607,NC(=S)c1sc(N2CCCC2)nc1N>>Nc1snc2nc(N3CCCC3)sc12,,CC(=O)O,,OO,,val
US20070149575A1,CC#N.CCCCCCC.CCOC(C)=O.N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1S(=O)C(F)(F)F>>CC[NH+](CC)CCCl.[Cl-],,CC#N,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20040102493A1,COC(=O)CCCBr.Cc1cc(CCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1O>>COC(=O)CCCOc1ccc(CCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060142306A1,CC(C)(C)OC(=O)NCCOc1ccc(CCCCNC(=O)OCc2ccccc2)cc1>>CC(C)(C)OC(=O)NCCOc1ccc(CCCCN)cc1,[Pd],CCO,,[H][H],,val
US20120316151A1,CCOC(=O)CC1CN(C(=O)C2CC2)C1.NN>>NNC(=O)CC1CN(C(=O)C2CC2)C1,,CCO,,O,,val
US20050096380A1,CC(C)[Mg]Cl.COc1cc2c(cc1Br)C(=O)CC(C)(C)O2>>COc1cc2c(cc1Br)C(C(C)C)=CC(C)(C)O2,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05773227,O=[N+]([O-])c1cc(OCc2ccccc2)ccc1O>>Nc1cc(OCc2ccccc2)ccc1O,[Pt],CN(C)C=O,,[H][H],,val
US05219871,BrCCc1ccc2c(c1)CCC2.CNCCCC(C(N)=O)(c1ccccc1)c1ccccc1>>CN(CCCC(C(N)=O)(c1ccccc1)c1ccccc1)CCc1ccc2c(c1)CCC2,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160185786A1,N#Cc1ccc(N2CCNCC2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=c1c2cccn2ncn1CC1(O)CCNCC1>>N#Cc1ccc(N2CCN(C(=O)N3CCC(O)(Cn4cnn5cccc5c4=O)CC3)CC2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US06541491B1,C=CCOC(=O)N1C[C@@H](SC(=O)OC(C)(C)C)C[C@H]1CN.COC(=O)[C@H](CCS(C)(=O)=O)NC(=O)c1cccc(S(=O)(=O)Cl)c1>>C=CCOC(=O)N1C[C@@H](SC(=O)OC(C)(C)C)C[C@H]1CNS(=O)(=O)c1cccc(C(=O)N[C@@H](CCSC)C(=O)OC)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04009200,CC(C)(C)C1=CC(=O)C2C(C1=O)C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl>>CC(C)(C)c1cc(O)c2c(c1O)C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl,c1ccncc1,CO,,,,val
US20140303164A1,COC(=O)Cl.Cn1nc(N)c2c(Cl)ccc(-c3ccc(C#CC(C)(C)O[Si](C)(C)C(C)(C)C)nc3[C@H](Cc3cc(F)cc(F)c3)NC(=O)OC(C)(C)C)c21>>COC(=O)Nc1nn(C)c2c(-c3ccc(C#CC(C)(C)O)nc3[C@@H](N)Cc3cc(F)cc(F)c3)ccc(Cl)c12,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20100075948A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1.CC(C)[C@H](N)C(=O)OC(C)(C)C>>CC(C)[C@H](NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2)[C@H]1c1cccc(Cl)c1)C(=O)OC(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090099171A1,COC(=O)c1c(O)c2cc(Cl)nnc2n(C)c1=O.COC(=O)c1c(O)c2cc(OC)nnc2n(C)c1=O.N>>COc1cc2c(O)c(C(=O)NCC(=O)O)c(=O)n(C)c2nn1,,CO,,C[O-].[Na+],,val
US03983111,C[C@]12CC[C@@H](O)C[C@@H]1CC[C@@H]1[C@@H]2C(=O)C[C@]2(C)[C@@H](C(=O)CN3CCOCC3)CC[C@@H]12.Cl>>C[C@]12CC[C@@H](O)C[C@@H]1CC[C@@H]1[C@@H]2C(=O)C[C@]2(C)[C@@H](C(=O)CN3CCOCC3)CC[C@@H]12.Cl,,CCO,,,,val
US04414226,CO.COc1cc(C)cc2c(=O)oc3c(c12)C(=O)c1cccc(O)c1C3=O.O=S(=O)(Cl)Cl>>COC(=O)c1c(Cl)c(C)cc(OC)c1C1=C(O)C(=O)c2c(O)cccc2C1=O,,CC(=O)O,ClCCl,,,val
US20130178486A1,C[Si](C)(C)C#Cc1ncc(F)cc1N>>Fc1cnc2cc[nH]c2c1,,CN(C)C=O,,[H-].[Na+],,val
US20160152613A1,CC1(C)OC(=O)CC(=O)O1.O=Cc1cc(Cl)ccc1Cl>>CC1(C)OC(=O)C(=Cc2cc(Cl)ccc2Cl)C(=O)O1,,Cc1ccccc1,O,C1CCNCC1,CC(=O)O,val
US20140107122A1,CC(=O)CC(C)=O.N#CCC(N)=O>>Cc1cc(C)c(C#N)c(=O)[nH]1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20110112070A1,Nc1cc(-c2cccc(OC3CCCCO3)c2)cc2nn(C3CCCCO3)cc12.O=C(Cl)C1CCCCC1>>O=C(Nc1cc(-c2cccc(O)c2)cc2[nH]ncc12)C1CCCCC1,,ClCCl,,CCN(C(C)C)C(C)C,[Na+].[OH-],val
US04791139,CCOc1ccc(/C(=C\C(=O)OC)C(F)(F)F)cc1>>CCOc1ccc(C(CC(=O)OC)C(F)(F)F)cc1,[Pd],CCO,,,,val
US20130331452A1,CCOC(=O)c1ccc(OC)c(OCc2c(C)cccc2C)c1>>COc1ccc(C(=O)O)cc1OCc1c(C)cccc1C,,CCO,,[Na+].[OH-],,val
US20040082571A1,CC(C)c1cc(C(C)C)[nH]n1.O=C(CCl)N1CCN(c2ccc(F)cc2)CC1>>CC(C)c1cc(C(C)C)n(CC(=O)N2CCN(c3ccc(F)cc3)CC2)n1,,CCCCCC,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20060229349A1,COC(=O)Cl.NC[C@@H]1CN(c2cc(F)c3c(c2)CC(=O)N3C2CC2)C(=O)O1>>COC(=O)NC[C@H]1CN(c2cc(F)c3c(c2)CC(=O)N3C2CC2)C(=O)O1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20030096826A1,CCOC(=O)CCl.O=Cc1cccc2ccccc12>>CCOC(=O)C1OC1c1cccc2ccccc12,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20040167119A1,C=O.CC(N)Cc1c[nH]c2ccc(OCc3ccccc3)cc12>>CC1Cc2c([nH]c3ccc(OCc4ccccc4)cc23)CN1,,CCO,,CC(=O)O,,val
US04587256,CCCCCCCCCCC(=O)Cl.Nc1cc(F)cc2c1OCCC21SC(=O)NC1=O>>CCCCCCCCCCC(=O)Nc1cc(F)cc2c1OCCC21SC(=O)NC1=O,,c1ccncc1,,,,val
US20100305096A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3C[C@@H]4C[C@H]3CN4C(=O)OC(C)(C)C)n(C)c2n1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04152442,CNc1nnc(C)s1.O=C(Cl)c1ccccc1>>Cc1nnc(N(C)C(=O)c2ccccc2)s1,,c1ccncc1,,,,val
US20110065681A1,COC(=O)c1cc(O)cc(-c2ccc(C)cc2)c1.COCCBr>>COCCOc1cc(C(=O)OC)cc(-c2ccc(C)cc2)c1,,CCOC(C)=O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20150148333A1,Cc1cccc2c1NCCc1onc(C)c1-2.O=Cc1ccccc1>>Cc1cccc2c1N(Cc1ccccc1)CCc1onc(C)c1-2,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US04380675,C=CCC(C=C(C=O)CC)CC>>CCCC(CC)CC(CC)CO,[Ni],CO,,,,val
US20040142982A1,NCC1CCCCC1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CN(C1CCCCC1)S(=O)(=O)c1ccccc1N,,CCOC(C)=O,,c1ccncc1,,val
US20100210672A1,COc1ncc(-c2cnsc2)c(OC)n1.Cl>>Cl.O=c1[nH]cc(-c2cnsc2)c(=O)[nH]1,,C1COCCO1,,,,val
US20110230486A1,COc1cccc(Oc2cc(C)c(C(=O)CBr)c(C)c2)c1.NC(N)=S>>COc1cccc(Oc2cc(C)c(-c3csc(N)n3)c(C)c2)c1,,CCO,,,,val
US04086241,O=C=Nc1nc2cc(Cl)c(Cl)cc2s1.O=CCNCCBr>>O=CCN(CCBr)C(=O)Nc1nc2cc(Cl)c(Cl)cc2s1,,c1ccccc1,,,,val
US20130338137A1,CC(C)(C)OC(=O)NC1CCN(c2nc(-c3nn(Cc4ccccc4F)c4ncccc34)nc3c2C(C)(C)C(=O)N3)C1>>CC1(C)C(=O)Nc2nc(-c3nn(Cc4ccccc4F)c4ncccc34)nc(N3CCC(N)C3)c21,,CCOCC,,Cl,,val
US20100298328A1,CCCCCCBr.COc1c(OC)c(=O)c1=O>>CCCCCCc1c(OC)c(=O)c1=O,,CCOCC,,C1CCOC1,,val
US05521147,COc1ccc(N)c2c1CC(C)(C)O2.O=C(Cl)OC(Cl)(Cl)Cl>>COc1ccc(N=C=O)c2c1CC(C)(C)O2,,Cc1ccccc1,,,,val
US06469021B1,O=CNCc1cc2c3ccccc3n(Cc3cc(Cl)ccc3Cl)c2cn1>>NCc1cc2c3ccccc3n(Cc3cc(Cl)ccc3Cl)c2cn1,,CCO,O,[K+].[OH-],,val
US05547967,CNCCc1ccc(OC)c(OC)c1.ClCCCBr>>COc1ccc(CCN(C)CCCCl)cc1OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120157425A1,CC(C)O.C[C@H](NC(=O)C1CC1)c1ccc(C2CCN(c3cc(Cl)ncn3)CC2)cc1>>CC(C)Oc1cc(N2CCC(c3ccc([C@H](C)NC(=O)C4CC4)cc3)CC2)ncn1,,O,,[H-].[Na+],,val
US20090023811A1,CCOC(=O)c1ccc(-c2ccc(OCCCO[Si](C)(C)C(C)(C)C)c(-c3ccc4c(c3)C(C)(C)CCC4(C)C)c2)cc1>>CCOC(=O)c1ccc(-c2ccc(OCCCO)c(-c3ccc4c(c3)C(C)(C)CCC4(C)C)c2)cc1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20040162321A1,C=O.COc1ccc(F)cc1C(C)(C)CC(O)(CN1CCNc2ccccc21)C(F)(F)F>>COc1ccc(F)cc1C(C)(C)CC(O)(CN1CCN(C)c2ccccc21)C(F)(F)F,,CC#N,,CC(=O)O,[BH3-]C#N.[Na+],val
US20050107388A1,[N-]=[N+]=NCCc1cc2ccccc2cn1>>NCCc1cc2ccccc2cn1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050261496A1,NC(=O)c1[nH]c2ccc(C#Cc3ccccc3)cc2c1S(=O)(=O)N1CCOCC1>>NC(=O)c1[nH]c2ccc(CCc3ccccc3)cc2c1S(=O)(=O)N1CCOCC1,,CO,,,,val
US20060041144A1,O=C(Nc1cccnc1Cl)C(=O)c1ccc(Cl)cc1>>O=C(Nc1cccnc1Cl)C(O)c1ccc(Cl)cc1,,CCO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20100152197A1,CC(C)(C)OC(=O)N1CCN(C(C)(C)C)C[C@@H]1C(=O)N1CCNCC1.Cc1nc(NC(=O)Oc2ccccc2)sc1Cl>>Cc1nc(NC(=O)N2CCN(C(=O)[C@H]3CN(C(C)(C)C)CCN3)CC2)sc1Cl,,C1CCOC1,,,,val
US20130137675A1,BrCc1ccccc1.COc1cn(-c2ccncc2)nc(-c2ccnn2-c2ccccc2)c1=O>>O=c1ccn(-c2cc[n+](Cc3ccccc3)cc2)nc1-c1ccnn1-c1ccccc1.[Br-],,CC#N,,,,val
US20040180897A1,CO.COc1nccc(I)c1C(=O)O>>COC(=O)c1c(I)ccnc1OC,,CO,,C[Si](C)(C)C=[N+]=[N-],,val
US20100179118A1,C1CCNCC1.CC(C)(C)OC(=O)N1CCC(N(C(=O)CCl)c2ccccc2)CC1>>CC(C)(C)OC(=O)N1CCC(N(C(=O)CN2CCCCC2)c2ccccc2)CC1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20110201577A1,CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@@H](NC(C)=O)[C@H](N=[N+]=[N-])[C@@H]1O.CS(=O)(=O)Cl>>CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@@H](NC(C)=O)[C@H](N=[N+]=[N-])[C@@H]1OS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20150266895A1,O=Cc1nc(Cl)cc2c1c(N1CCOCC1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1>>OCc1nc(Cl)cc2c1c(N1CCOCC1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1,,CO,ClCCl,[BH4-].[Na+],,val
US20050256159A1,CNc1ccc(F)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C(c1ccc(F)cc1)C1CCNCC1>>CN(C(=O)N1CCC(C(=O)c2ccc(F)cc2)CC1)c1ccc(F)cc1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US05475007,O=N[O-].Oc1cc(O)c2c(Cl)cc(Cl)cc2n1>>O=C1Nc2cc(Cl)cc(Cl)c2C(=O)C1=NO,,[Na+],[OH-],O=S(=O)(O)O,,val
US04032639,O=C1Nc2cc(NC(=O)C(F)(F)F)ccc2N2CCN(C(=O)OCc3ccccc3)CC12>>Nc1ccc2c(c1)NC(=O)C1CN(C(=O)OCc3ccccc3)CCN21,,O,,[Na+].[OH-],,val
US06521629B2,CCBr.COc1cc([N+](=O)[O-])c(C#N)c(I)c1O>>CCOc1c(OC)cc([N+](=O)[O-])c(C#N)c1I,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080096861A1,CN(Cc1nc2ccccc2n1CC1CN(C(=O)OC(C)(C)C)C1)C1CCCc2cccnc21>>CN(Cc1nc2ccccc2n1CC1CNC1)C1CCCc2cccnc21,,ClCCl,O=C(O)C(F)(F)F,,,val
US20130225584A1,CC(=O)OC(C)=O.COC(=O)c1cc(C)c(Br)cc1O>>COC(=O)c1cc(C)c(Br)cc1OC(C)=O,,c1ccncc1,,,,val
US20120035237A1,Nc1c(F)cccc1F.O=C(O)c1cnn(Cc2cc(Cl)ccc2OCc2ccccc2)n1>>O=C(Nc1c(F)cccc1F)c1cnn(Cc2cc(Cl)ccc2OCc2ccccc2)n1,,CO,,CCN(CC)CC,O=S(Cl)Cl,val
US05807862,CCCCCCCCC=CCCCCCCCCBr.Cn1cnc2c1c(=O)[nH]c(=O)n2C>>CCCCCCCCC=CCCCCCCCCn1c(=O)c2c(ncn2C)n(C)c1=O,,CS(C)=O,,O,[H-].[Na+],val
US06534546B1,CCI.O=C1c2ccccc2C(=O)N1Cc1cc([N+](=O)[O-])ccc1O>>CCOc1ccc([N+](=O)[O-])cc1CN1C(=O)c2ccccc2C1=O,,CN(C)C=O,,O,[H-].[Na+],val
US20070167443A1,COc1ccc(C(=O)c2c[nH]c3ccccc3c2=O)cc1C.N#Cc1cccc(CBr)n1>>COc1ccc(C(=O)c2cn(Cc3cccc(C#N)n3)c3ccccc3c2=O)cc1C,,CN(C)C=O,,,,val
US05453423,CC(C)(C)OC(=O)N1CCCC1COC(=O)N1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1>>O=C(OCC1CCCN1)N1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20140073622A1,C=C(C)CCl.COC1(OC)CCN(C(=O)OC(C)(C)C)CC1O>>C=C(C)COC1CN(C(=O)OC(C)(C)C)CCC1(OC)OC,,CN(C)C=O,,[H-].[Na+],,val
US05243035,CCCCCCCCCCCCCCCC(=O)Cl.NCCO>>CCCCCCCCCCCCCCCC(=O)NCCO,,ClC(Cl)Cl,,,,val
US05004780,CCCC(C)(C)OO.COC1(OC)CC(C)CC(C)(C)C1>>CCCC(C)(C)OOC1(OC)CC(C)CC(C)(C)C1,Cc1ccc(S(=O)(=O)O)cc1,CS(C)=O,,,,val
US20120149676A1,CNc1cc(Cl)c(C(=O)NCCC(F)(F)F)cc1[N+](=O)[O-].FC(F)(F)C1CCCNC1>>CNc1cc(N2CCCC(C(F)(F)F)C2)c(C(=O)NCCC(F)(F)F)cc1[N+](=O)[O-],,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20150105373A1,CC(C)(O)Cc1ccc(OC(F)(F)F)cc1.CI>>COC(C)(C)Cc1ccc(OC(F)(F)F)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20160130237A1,COCCN.Clc1cc(Cl)ncn1>>COCCNc1cc(Cl)ncn1,,CC(C)O,,CCN(C(C)C)C(C)C,O,val
US20080280868A1,COC(=O)c1ccc(=O)[nH]c1C1CC1.O=P(Cl)(Cl)Oc1ccccc1>>COC(=O)c1ccc(Cl)nc1C1CC1,,O=C([O-])O,[Na+],,,val
US20100305093A1,COC(=O)N=C(NC(=O)OC)SC.CS(=O)(=O)c1ccc(C(=O)N2CCOc3ccc(-c4ccc(N)c(N)c4)cc3C2)cc1>>COC(=O)Nc1nc2ccc(-c3ccc4c(c3)CN(C(=O)c3ccc(S(C)(=O)=O)cc3)CCO4)cc2[nH]1,,CC(=O)O,,,,val
US20030032645A1,C1=C(c2c[nH]c3ccccc23)CC2CCC1N2.ClCCOc1cccc2[nH]ccc12>>C1=C(c2c[nH]c3ccccc23)CC2CCC1N2CCOc1cccc2[nH]ccc12,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05221750,CC(C)(C)c1cc(O)no1.CS(=O)(=O)c1ccc(Cl)c(S(C)(=O)=O)c1>>CC(C)(C)c1cc(=O)n(-c2ccc(S(C)(=O)=O)cc2S(C)(=O)=O)o1,,O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20020143023A1,COC1=NC(C)=C(C(=O)OCc2ccccc2)C(c2cccc(Cl)c2)N1C(=O)Oc1ccc([N+](=O)[O-])cc1.NCCC(c1ccccc1)c1ccccc1>>CC1=C(C(=O)OCc2ccccc2)C(c2cccc(Cl)c2)N(C(=O)NCCC(c2ccccc2)c2ccccc2)C(=O)N1,,CC#N,,,,val
US20060293352A1,CCOC(=O)c1ccc(Sc2cc(Cl)ccc2OC)cc1>>COc1ccc(Cl)cc1Sc1ccc(C(=O)O)cc1,,CO,O,Cl,[Li+].[OH-],val
US20160096827A1,CC(=O)N1CC[C@H](Oc2ccc(-c3ncnc(Nc4ccc(C5CCN(C(=O)OC(C)(C)C)CC5)cc4)n3)cc2C#N)C(F)(F)C1>>CC(=O)N1CC[C@H](Oc2ccc(-c3ncnc(Nc4ccc(C5CCNCC5)cc4)n3)cc2C#N)C(F)(F)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120136016A1,Cc1ccc(-c2ncnc(C(=O)OCc3ccccc3)c2OCc2ccccc2)cc1>>Cc1ccc(-c2ncnc(C(=O)O)c2OCc2ccccc2)cc1,,CO,,O,[Li+].[OH-],val
US20050143379A1,CC(C)(C)OC(=O)NCC(=O)c1cccnc1>>CC(C)(C)OC(=O)NCC(O)c1cccnc1,,CCO,,[BH4-].[Na+],,val
US20030125334A1,Cl.Clc1cccc(COc2cncc(N3CCNCC3)n2)c1>>Cl.Clc1cccc(COc2cncc(N3CCNCC3)n2)c1,,CCOCC,ClCCl,CCCCCC,,val
US04596815,O=C(CBr)c1ccc(Br)s1.Oc1ccc(Cl)cc1>>O=C(COc1ccc(Cl)cc1)c1ccc(Br)s1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20150018422A1,CC(C)(C)CBr.COc1ccc(COc2ccc(-c3cc(OC)ccc3F)c(C=O)c2)cc1>>COc1ccc(COc2ccc(-c3cc(OC)ccc3F)c(C(O)CC(C)(C)C)c2)cc1,,CCOCC,,[Mg],[Cl-].[NH4+],val
US20020173490A1,COc1ccc(Cl)cc1NC(N)=S>>COc1ccc(Cl)c2sc(N)nc12,,ClC(Cl)Cl,,BrBr,,val
US20070149508A1,CC(C)(C)OC(=O)N1CCNCC1.O=S(=O)(Cl)c1ccc(Br)cc1F>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(Br)cc2F)CC1,,O,,,,val
US20080146542A1,CN(NC(=O)c1cc2c(NC(=O)c3ccc(CN4CCOCC4)cc3)nn(C(=O)OC(C)(C)C)c2s1)c1ccccc1>>CN(NC(=O)c1cc2c(NC(=O)c3ccc(CN4CCOCC4)cc3)n[nH]c2s1)c1ccccc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US04749704,CC(=O)OC1CCc2c(Cl)ncnc21.N#Cc1ccc(N)cc1>>CC(=O)OC1CCc2c(Nc3ccc(C#N)cc3)ncnc21,,CCO,,,,val
US04886809,Cl.NO.O=C1CCc2cc(C(=O)N3CCN(CCC(=O)c4ccccc4)CC3)ccc2N1>>Cl.O=C1CCc2cc(C(=O)N3CCN(CC(O)c4ccccc4)CC3)ccc2N1,,c1ccncc1,,O,,val
US04978753,CC#CCC(=O)O.NC1=Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1>>CCc1cc(=O)nc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2,,C1CCOC1,CN(C)C=O,O=C(n1ccnc1)n1ccnc1,,val
US20040023968A1,O=C(CC(C(=O)O)c1ccccc1)Nc1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F>>O=C1CC(c2ccccc2)C(=O)N1c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20050288273A1,CCOC(=O)Cl.COC(=O)CCCCc1cc(N)cc(F)c1>>CCOC(=O)Nc1cc(F)cc(CCCCC(=O)OC)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160016948A1,COC(=O)C1(F)CN(C(=O)OC(C)(C)C)CC(F)C1=O>>CC(C)(C)OC(=O)N1CC(F)C(=O)C(F)(C(=O)O)C1,,CO,O,Cl,[Li+].[OH-],val
US08431695B2,CC(C)(C)OC(=O)N1CCCC(c2ccc3c(N)ncnn23)C1.CC1(C)C(=O)N(Br)C(=O)N1Br>>CC(C)(C)OC(=O)N1CCCC(c2cc(Br)c3c(N)ncnn23)C1,,CC(=O)O,CN(C)C=O,,,val
US20070232628A1,CCCC(C(C)=O)C(=O)Nc1ccc(C(C)C)cc1.NC(=O)c1ccccc1O>>CCCc1c(C)nc(-c2ccccc2O)n(-c2ccc(C(C)C)cc2)c1=O,,Cc1ccccc1C,,,,val
US06008230,CC(=NO)c1cnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1.O=P(Cl)(Cl)Cl>>CC(=O)Nc1cnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1,,c1ccncc1,,,,val
US20080070850A1,O=C(Cl)C(=O)Cl.O=C(O)c1ccc(-c2ccc(C(=O)O)cc2)cc1>>O=C(Cl)c1ccc(-c2ccc(C(=O)Cl)cc2)cc1,CN(C)C=O,,,ClCCl,,val
US20090082440A1,CC(C)(COS(=O)(=O)CCCCl)[C@@H](OCc1ccccc1)C(=O)O.CC(C)O>>CC(C)OC(=O)[C@H](OCc1ccccc1)C(C)(C)COS(=O)(=O)CCCCl,,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20100029782A1,CO.O=C(O)CCCc1ccccc1>>COC(=O)CCCc1ccccc1,,O,,O=S(=O)(O)O,,val
US20150141406A1,COc1nccc2c(-c3ccccc3)nn(-c3ccccc3)c12>>O=c1[nH]ccc2c(-c3ccccc3)nn(-c3ccccc3)c12,,CC#N,,C[Si](C)(C)Cl,[I-].[Na+],val
US20060189623A1,CC(C)OB1OC(C)(C)C(C)(C)O1.Cc1ccsc1Br>>Cc1ccsc1B1OC(C)(C)C(C)(C)O1,,C1CCOC1,,[Li]CCCC,,val
US20140275026A1,COc1nc(Br)cc2c(-c3cc([N+](=O)[O-])ccc3F)cn(C)c12.Oc1ccc(F)cc1F>>COc1nc(Br)cc2c(-c3cc([N+](=O)[O-])ccc3Oc3ccc(F)cc3F)cn(C)c12,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120035195A1,CON(C)C(=O)c1nn(C(F)F)cc1Cl>>O=Cc1nn(C(F)F)cc1Cl,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100249187A1,CC(C)(C)OC(=O)N1CCCC(C(=O)OCC(=O)C(C)(C)C)(C(=O)OCc2ccccc2)C1.Cl>>CC(C)(C)C(=O)COC(=O)C1(C(=O)OCc2ccccc2)CCCNC1.Cl,,CC(C)O,CCOC(C)=O,,,val
US06043242,CO.Cc1c(SCCCSc2ccc3ncc([N+](=O)[O-])n3n2)ccnc1CCl>>COCc1nccc(SCCCSc2ccc3ncc([N+](=O)[O-])n3n2)c1C,,CO,,C[O-].[Na+],,val
US04448962,CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21.O=N[O-]>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(N=O)CC3)cc21,,CC(=O)O,,O,,val
US20040058903A1,C=Cc1ccccn1.Cc1cc(N)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1>>Cc1cc(NCCc2ccccn2)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1,,COCCO,,CS(=O)(=O)O,,val
US20160072082A1,CC(C)=Cc1cnc2c3ccccc3c3c(C)cccc3n12>>Cc1ccc2c3c1c1ccccc1c1ncc(n13)CC2(C)C,,ClCCl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20020035110A1,CCOC(=O)c1cc2c(Br)cccc2[nH]1.N#CCCl>>CCOC(=O)c1cc2c(Br)cccc2n1CC#N,,CN(C)C=O,,[H-].[Na+],,val
US20050228155A1,CC(C)(C)C1=CC=CC1.CCC(=O)CC>>CCC(CC)=C1C=CC(C(C)(C)C)=C1,,C1CCOC1,O,CCCCCC,[Li]CCCC,val
US05037883,CC(C)(C)OC(=O)OC(C)(C)C.CC(C)[C@H](N)C(=O)O>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O,,C1COCCO1,O,,,val
US20130137679A1,CC(C)Oc1ccccc1N1CCCN(C(=O)OC(C)(C)C)CC1.Cl>>CC(C)Oc1ccccc1N1CCCNCC1.Cl,,CCOC(C)=O,,,,val
US20070049632A1,CCOC(=O)c1c[nH]nc1C(F)(F)F.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)nc1C(F)(F)F,,CN(C)C=O,,CCN(CC)CC,,val
US20040019016A1,BrCc1ccccc1.COC(=O)c1cc(Cl)c(O)c(Cl)c1>>COC(=O)c1cc(Cl)c(OCc2ccccc2)c(Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030069297A1,CCN(CC)CCNC(=O)c1cc(C)c(C=O)[nH]1.O=C1Cc2c(cccc2-c2cccc(Cl)c2)N1>>CCN(CC)CCNC(=O)c1cc(C)c(C=C2C(=O)Nc3cccc(-c4cccc(Cl)c4)c32)[nH]1,C1CCNCC1,CCO,,,,val
US05340810,CC(=O)c1ccc(Br)c(C)c1.Cc1ccc(S(=O)(=O)NN)cc1>>Cc1cc(-c2csnn2)ccc1Br,,CCO,,,,val
US04777281,CCC=C1CCc2cc(OC)c(Cl)c(Cl)c2C1=O>>CCCC1CCc2cc(OC)c(Cl)c(Cl)c2C1=O,[Pd],CC(C)O,,,,val
US20160108035A1,CCOC(=O)C1(Sc2ccc(C#N)c3ccccc23)CCC1>>N#Cc1ccc(SC2(C(=O)O)CCC2)c2ccccc12,,C1CCOC1,O,[Li+].[OH-],,val
US06025388,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=CCc1cccc(Br)c1>>CCOC(=O)C=CCc1cccc(Br)c1,,ClCCl,,,,val
US20100204480A1,CC(=O)O.CCCN.CCOC(=O)CC(=O)CCl>>CCCNC(=CCC(=O)OCC)CCl,,CCO,,Cc1ccccc1,,val
US04238621,COC(=O)c1ccccc1S(=O)(=O)N=C=O.COc1nc(C)nc(N)n1>>COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(C)nc(OC)n1,,ClCCl,,,,val
US20140155389A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc2c(c1)CCNC2>>COc1ccc2c(c1)CCN(C(=O)OC(C)(C)C)C2,,ClCCl,,CCN(CC)CC,O,val
US20090214444A1,CC(C)(C)OC(=O)NCCCBr.O=Cc1ccc(O)c2ccccc12>>CC(C)(C)OC(=O)NCCCOc1ccc(C=O)c2ccccc12,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040132769A1,CNC.COc1ccc(Br)c(CC(=O)Cl)c1>>COc1ccc(Br)c(CC(=O)N(C)C)c1,,CCOCC,,,,val
US20150141372A1,COCC(=O)Cl.COc1c(N)nc(-c2nn(Cc3ccccc3F)c3c2CCC3)nc1Nc1ccncc1>>COCC(=O)N(c1ccncc1)c1nc(-c2nn(Cc3ccccc3F)c3c2CCC3)nc(N)c1OC,,CN(C)C=O,,CCN(CC)CC,,val
US04999378,COC(=O)c1ccc(OCCCNc2ccc([N+](=O)[O-])cc2)cc1>>COC(=O)c1ccc(OCCCNc2ccc(N)cc2)cc1,[Pd],CO,,,,val
US20080292608A1,CC(=O)OC(C)=O.Cc1cc(OCc2ccccc2)c(C)cc1CO>>CC(=O)OCc1cc(C)c(OCc2ccccc2)cc1C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160184318A1,Cc1cn(C2CCN(C(=O)OC(C)(C)C)CC2)nn1>>Cc1cn(C2CCNCC2)nn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120202785A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(F)cc1NCc1ccccc1>>C[C@H](NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2n1Cc1ccccc1,,CC(=O)O,,,,val
US20050272762A1,N#Cc1c[nH]c(=O)c2ccsc12.NC(=O)CCC(=O)NBr>>N#Cc1c[nH]c(=O)c2cc(Br)sc12,,CN(C)C=O,,O,,val
US20010027196A1,Cc1cnn(-c2nc(N)nc(S(C)=O)c2C#N)c1.SCCc1ccccn1>>Cc1cnn(-c2nc(N)nc(SCCc3ccccn3)c2C#N)c1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20140255381A1,C1CCOC1.CC(N=C=O)c1cccc2ccccc12.CCN(CC)CC.Nc1c(F)c(N)c(F)c(F)c1F>>CC(NC(=O)NC1CN2CCC1CC2)c1cccc2ccccc12,,C1CCOC1,,Cl,Cl,val
US20100035874A1,CC(=O)CC(C)=O.Cc1nn2c(-c3ccc(Cl)cc3Cl)c(C)oc2c1N(NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>Cc1cc(C)n(-c2c(C)nn3c(-c4ccc(Cl)cc4Cl)c(C)oc23)n1,,O,,CC(=O)O,,val
US20080319005A1,CCN(CC)Cc1ccc(N)cc1C(F)(F)F.Cc1cc(-n2cnc3cccnc32)ccc1CC(=O)O>>CCN(CC)Cc1ccc(NC(=O)Cc2ccc(-n3cnc4cccnc43)cc2C)cc1C(F)(F)F,,CO,ClCCl,,,val
US20050085509A1,COC(=O)C(N)Cc1ccc(F)cc1F.O=C(CBr)Nc1c(Cl)cccc1Cl>>COC(=O)C(Cc1ccc(F)cc1F)NCC(=O)Nc1c(Cl)cccc1Cl,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,O,val
US20070185097A1,COC(=O)c1cc(SCCc2ccccc2)c[nH]1>>O=C(O)c1cc(SCCc2ccccc2)c[nH]1,,CO,O,Cl,[K+].[OH-],val
US20160272617A1,CC(C)(C)OC(=O)N1CCC(N)CC1.Cc1cc(C(=O)O)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1>>Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110152233A1,CCN(C(=O)Oc1ccc(F)cc1)[C@@H]1CNC[C@H]1c1ccc(F)cc1.N#Cc1ccc(N2CCC(C(=O)O)CC2)nc1>>CCN(C(=O)Oc1ccc(F)cc1)[C@@H]1CN(C(=O)C2CCN(c3ccc(C#N)cn3)CC2)C[C@H]1c1ccc(F)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04058550,CCCCCCCCCCCCCCCCNc1ccc(C(=O)OCC2CO2)cc1.O=S(=O)(O)O>>CCCCCCCCCCCCCCCCNc1ccc(C(=O)OCC(O)CO)cc1,,O,,COCCOC,,val
US20110263578A1,CN(C)S(=O)(=O)Cl.Fc1cccnc1[C@@H]1CC[C@@H](c2nnc3n2-c2ccc(Cl)cc2CNC3)CC1>>CN(C)S(=O)(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2[C@@H]2CC[C@@H](c3ncccc3F)CC2)C1,,ClCCl,,CCN(CC)CC,,val
US20120214784A1,COC(=O)c1cccc(F)c1-n1cc(C=O)c(C)n1.FC1(F)COC2(CCNCC2)c2sc(Cl)cc21>>COC(=O)c1cccc(F)c1-n1cc(CN2CCC3(CC2)OCC(F)(F)c2cc(Cl)sc23)c(C)n1,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070033742A1,Cc1ccc(Cn2ncc(N)c2N)cc1.O=Cc1ccc(O)cc1>>Cc1ccc(Cn2ncc(N=Cc3ccc(O)cc3)c2N)cc1,,CO,O,,,val
US04812164,C=CC(=O)Cl.COc1nc(C(F)(F)F)c(F)c(=O)n1-c1cc(O)c(Cl)cc1F>>C=CC(=O)Oc1cc(-n2c(OC)nc(C(F)(F)F)c(F)c2=O)c(F)cc1Cl,,CN(C)C=O,,[H-].[Na+],,val
US20090054665A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.COC(=O)C1C(C)=CC(=O)N1C(=O)OC(C)(C)C>>COC(=O)c1[nH]c(O[Si](C)(C)C(C)(C)C)cc1C,,ClCCl,,Cc1cccc(C)n1,,val
US20100197679A1,COc1ccc2ncc(=O)n(-c3cnc4c(c3)CCC(N)C4)c2n1.ClCCl.O=Cc1ccc2c(c1)OCCO2>>COc1ccc2ncc(=O)n(-c3cnc4c(c3)CCC(NCc3ccc5c(c3)OCCO5)C4)c2n1.Cl,,CO,,O=C([O-])O.[Na+],,val
US05017724,COc1c(C)cc(C)c2c1C(=O)C1CCCCC21>>COc1c(C)cc(C)c2c1C(O)C1CCCCC21,,CO,O,[BH4-].[Na+],,val
US20100152157A1,CCOC(=O)Cl.Clc1ccc2nc(-c3ccccc3)cn2n1.c1ccnnc1>>CCOC(=O)N1C=CC(c2c(-c3ccccc3)nc3ccc(Cl)nn23)C=N1,,ClCCl,,,,val
US03974141,CC(C)(C)C(=O)Cl.O=C1NCCN1>>CC(C)(C)C(=O)N1CCNC1=O,,C1CCOC1,,CCN(CC)CC,,val
US20070213359A1,COc1cccc2c(C#N)c[nH]c12.ClCCCI>>COc1cccc2c(C#N)cn(CCCCl)c12,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040132794A1,C[Si](C)(C)CCOCn1nc(N)c2cc(-c3ccccc3)c(F)c(F)c21>>Nc1n[nH]c2c(F)c(F)c(-c3ccccc3)cc12,,CO,,Cl,,val
US04881967,CC1Cc2c(N=C=O)ccc(Cl)c2O1.CCOC(=O)CNC>>CC1Cc2c(N3C(=O)CN(C)C3=O)ccc(Cl)c2O1,,ClCCl,,CCN(CC)CC,Cl,val
US20130115190A1,CCN(CC)C(=O)c1ccc(OC)cc1C.CN(C)C#N>>COc1ccc2c(O)nc(N(C)C)cc2c1,,C1CCOC1,,CCCCC,[Li]C(C)(C)C,val
US04861769,CCOC(=O)C(=NOC1CC1)c1nsc(N)n1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)C(=NOC1CC1)c1nsc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,CN(C)c1ccncc1,c1ccncc1,,,,val
US04237278,CC(C)(C)N.Cc1nnc(C=Cc2ccccc2OCC2CO2)s1>>Cc1nnc(C=Cc2ccccc2OCC(O)CNC(C)(C)C)s1,,Cc1ccccc1,,,,val
US04874764,CCOC(=O)N1CCN(c2c(F)cc([N+](=O)[O-])c(F)c2CO)CC1.O=S(Cl)Cl>>CCOC(=O)N1CCN(c2c(F)cc([N+](=O)[O-])c(F)c2CCl)CC1,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20120208828A1,Cc1ccc(-c2nnc(CCl)o2)cc1.Sc1nnc(-c2ccncn2)n1-c1ccccc1Cl>>Cc1ccc(-c2nnc(CSc3nnc(-c4ccncn4)n3-c3ccccc3Cl)o2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20030181726A1,COc1ccc(C(C[C@@H](C)N(Cc2ccccc2)C[C@H](O)COc2ccccc2)c2ccc(OC)cc2)cc1.O=C([O-])C(=O)[O-]>>COc1ccc(C(C[C@@H](C)NC[C@H](O)COc2ccccc2)c2ccc(OC)cc2)cc1.O=C(O)C(=O)O,[Pd],CO,,Cl,[H][H],val
US05670514,CN1C(=O)CC[C@]2(C)c3ccc(Br)cc3CC[C@@H]12.OB(O)c1ccc(C(F)(F)F)cc1>>CN1C(=O)CC[C@]2(C)c3ccc(-c4ccc(C(F)(F)F)cc4)cc3CC[C@@H]12,,ClC(Cl)Cl,,C1CCOC1,O=C([O-])[O-].[Na+].[Na+],val
US20090131461A1,CC(C)(C)OC(=O)N[C@@H](CCBr)C(=O)OC1CCCC1.COc1cc2c(Nc3cnc(NC(=O)c4ccccc4)nc3)ncnc2cc1O>>COc1cc2c(Nc3cnc(NC(=O)c4ccccc4)nc3)ncnc2cc1OCC[C@H](NC(=O)OC(C)(C)C)C(=O)OC1CCCC1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090137581A1,Cc1cccc2cc(C=O)c(Cl)nc12.OB(O)c1ccccc1C(F)(F)F>>Cc1cccc2cc(C=O)c(-c3ccccc3C(F)(F)F)nc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,O,O=C([O-])[O-].[Na+].[Na+],,val
US04400542,C=CCBr.CC(=O)c1cc(C(C)=O)c(O)cc1O>>C=CCc1c(O)c(C(C)=O)cc(C(C)=O)c1O,,ClCCCl,O,[Na+].[OH-],,val
US20120115902A1,CCOc1nc(N)c([N+](=O)[O-])cc1Br>>CCOc1nc(N)c(N)cc1Br,[Ni],C1CCOC1,,,,val
US05017578,CNn1cccc1.OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O>>CN(c1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)n1cccc1,,CCO,,O=C([O-])[O-].[Ca+2],,val
US20120171245A1,C[Mg]Br.O=C1CCC[C@H](Nc2nc(Cl)ncc2F)C1>>CC1(O)CCC[C@H](Nc2nc(Cl)ncc2F)C1,,C1CCOC1,,CCOC(C)=O,[Cl-].[NH4+],val
US05538988,CCOC(=O)c1c[nH]c(=S)n1C1CCc2c(F)cc(F)cc2C1>>O=C(O)c1c[nH]c(=S)n1C1CCc2c(F)cc(F)cc2C1,,CCO,O,[K+].[OH-],,val
US05530157,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccccc1Oc1ccccc1>>O=C(O)C=Cc1ccccc1Oc1ccccc1,,C1CCOC1,CCOC(C)=O,,,val
US20110166163A1,CCC1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.COC(=O)COc1cccc(Nc2ncnc3oc(-c4ccccc4)c(Br)c23)c1>>CCC1CC=C(c2c(-c3ccccc3)oc3ncnc(Nc4cccc(OCC(=O)O)c4)c23)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CS(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20110263428A1,Cc1cc(F)cc(C)c1C1C(=O)CC(=CC2CCOCC2)C1=O>>Cc1cc(F)cc(C)c1C1C(=O)CC(CC2CCOCC2)C1=O,[Pd],CO,,[H][H],,val
US20050228050A1,CC[C@@H](Cc1ccc(OC)c(C(=O)OCc2ccccc2)c1)C(=O)N1C(=O)OC[C@H]1Cc1ccccc1>>CC[C@@H](Cc1ccc(OC)c(C(=O)O)c1)C(=O)N1C(=O)OC[C@H]1Cc1ccccc1,[Pd],CCOC(C)=O,,,,val
US20160222022A1,CC(C)(C)C(=O)Cl.COC(=O)c1ccc2c(c1)OC[C@H](c1ccccc1)NC2>>COC(=O)c1ccc2c(c1)OC[C@H](c1ccccc1)N(C(=O)C(C)(C)C)C2,,O,,CCN(CC)CC,ClCCl,val
US04609396,CC(C#N)Oc1ccc(O)cc1.Clc1cnc2ccccc2n1>>CC(C#N)Oc1ccc(Oc2cnc3ccccc3n2)cc1,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US20110301142A1,COC(=O)CBr.Cc1noc(-c2ccc(-c3nn[nH]n3)cc2)c1NC(=O)O[C@H](C)c1ccccc1F>>COC(=O)Cn1nnc(-c2ccc(-c3onc(C)c3NC(=O)O[C@H](C)c3ccccc3F)cc2)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110028492A1,CC(C)(C)OC(=O)N1CCC(N)CC1.Fc1cc(I)c(Cl)cn1>>CC(C)(C)OC(=O)N1CCC(Nc2cc(I)c(Cl)cn2)CC1,,CCOC(C)=O,,CS(C)=O,,val
US20160200730A1,COc1ccc(CNC2CCC(CO)C2)c(OC)c1.CS(=O)(=O)Cl>>COc1ccc(CNC2CCC(COS(C)(=O)=O)C2)c(OC)c1,,ClCCl,,CCN(CC)CC,,val
US05696148,CCOC(=O)CC(=O)OCC.COc1ccc(CN2c3ccccc3CC2(Cl)C=O)cc1>>CCOC(=O)C(=Cc1c(Cl)n(Cc2ccc(OC)cc2)c2ccccc12)C(=O)OCC,,CCO,,C1CCNCC1,CC(=O)O,val
US20120238599A1,CN=C=Nc1ccc(I)cc1Cl.COC(=O)Cc1occc1C(=O)OC>>COC(=O)c1c(Nc2ccc(I)cc2Cl)n(C)c(=O)c2ccoc12,,C1CCOC1,,[H-].[Na+],,val
US20120322831A1,C=CCc1ccc(O)c(OC)c1.O=C(Br)CBr>>C=CCc1ccc(OC(=O)CBr)c(OC)c1,,CCOC(C)=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20080275064A1,Nc1cc(Cl)nc(-c2ccco2)n1.c1cn[nH]c1>>Nc1cc(-n2cccn2)nc(-c2ccco2)n1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20140221361A1,COC(=O)c1ccc(C2=CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC[C@@H]3[C@H]5[C@H](C6(C)CO6)CC[C@]5(NCCN5CCS(=O)(=O)CC5)CC[C@]34C)C2(C)C)cc1F>>CC1([C@@H]2CC[C@]3(NCCN4CCS(=O)(=O)CC4)CC[C@]4(C)[C@H](CC[C@@H]5[C@@]6(C)CC=C(c7ccc(C(=O)O)c(F)c7)C(C)(C)[C@@H]6CC[C@]54C)[C@@H]23)CO1,,C1COCCO1,,[Na+].[OH-],,val
US20120202834A1,CCOC(=O)c1ccc(C(=O)C(C)(C)C)cc1>>CC(C)(C)C(=O)c1ccc(C(=O)O)cc1,,CO,,C1CCOC1,[Na+].[OH-],val
US20010027196A1,CSc1nc(N)cc(-c2ccco2)c1C#N.O=S(=O)(c1ccccc1)N1OC1c1ccccc1>>CS(=O)c1nc(N)cc(-c2ccco2)c1C#N,,ClCCl,,,,val
US20150284369A1,COC(=O)c1c(N)cc(F)c2c1OCC1CC21.O=S(=O)(Cl)c1ccc(F)cc1Br>>COC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2Br)cc(F)c2c1OCC1CC21,,ClCCl,c1ccncc1,,,val
US20160272617A1,Cc1cc(C(=O)O)ccc1Br.N[C@H]1CC[C@H](O)CC1>>Cc1cc(C(=O)N[C@@H]2CC[C@@H](O)CC2)ccc1Br,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04261893,CN1C(=O)c2ccc(N)cc2C1=O.ClCC1CO1>>CN1C(=O)c2ccc(NCC(O)CCl)cc2C1=O,,OCC(F)(F)F,,,,val
US20130102576A1,COC(=O)Cn1c(=O)oc2cc([N+](=O)[O-])ccc21>>COC(=O)Cn1c(=O)oc2cc(N)ccc21,[Pd],CO,,CCOC(C)=O,,val
US20100093748A1,COC(=O)C1(NC(=O)OC(C)(C)C)CCNCC1.Clc1ncnc2[nH]cnc12>>COC(=O)C1(NC(=O)OC(C)(C)C)CCN(c2ncnc3[nH]cnc23)CC1,,CCO,,CCN(CC)CC,,val
US20100234395A1,COC(=O)C1(c2nc(-c3ccc(OC)cc3)c(-c3ccc(OC)cc3)o2)CCN(C(=O)OCc2ccccc2)CC1>>COc1ccc(-c2nc(C3(CO)CCN(C(=O)OCc4ccccc4)CC3)oc2-c2ccc(OC)cc2)cc1,,C1CCOC1,,O,[BH4-].[Li+],val
US20140350005A1,CC(C)(C)OC(=O)N1CCC2(CC1)C(=O)N(Cc1cccc(C(=O)O)c1)CN2c1ccccc1.CN(C)CCO>>CN(C)CCOC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCN(C(=O)OC(C)(C)C)CC3)C2=O)c1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04691026,CCOC(CCCN)OCC.O=C1C=CC(=O)O1>>CCOC(CCCNC(=O)/C=C\C(=O)O)OCC,,ClCCl,,,,val
US20100137299A1,BrCc1ccc(-c2ccno2)cc1.Cc1noc2cc3c(cc12)C1(CO3)C(=O)Nc2ccccc21>>Cc1noc2cc3c(cc12)C1(CO3)C(=O)N(Cc2ccc(C(=O)CC#N)cc2)c2ccccc21,,CN(C)C=O,,O,[H-].[Na+],val
US05506219,BrC(Br)(Br)Br.CC(C)c1cc(-c2ccccc2)nc(-c2ccc(F)cc2)c1C=O>>CC(C)c1cc(-c2ccccc2)nc(-c2ccc(F)cc2)c1C=C(Br)Br,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05068325,ClCC1=Cc2ccccc2CC1.Nc1nc2c(s1)CCNCC2>>Nc1nc2c(s1)CCN(CC1=Cc3ccccc3CC1)CC2,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US05912258,CC(C)(C)c1cc(C(=O)O)cc(C(C)(C)C)c1.CCN(CC)CCSc1nnc(N)s1>>CCN(CC)CCSc1nnc(NC(=O)c2cc(C(C)(C)C)cc(C(C)(C)C)c2)s1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20070123504A1,Cc1oc(C2CCCCC2)cc1C(=O)O.Nc1ccc(N2CCOCC2)nc1>>Cc1oc(C2CCCCC2)cc1C(=O)Nc1ccc(N2CCOCC2)nc1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20080312226A1,COc1cccc(-c2csc(N3CCNCC3)n2)c1.O=C(Nc1cccnc1)OCC(Cl)(Cl)Cl>>COc1cccc(-c2csc(N3CCN(C(=O)Nc4cccnc4)CC3)n2)c1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US05149696,BrC(Br)(Br)Br.CCCCN(C)C(=O)CCCCCC#CCO>>CCCCN(C)C(=O)CCCCCC#CCBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050070592A1,COc1ccc(-c2ccc3c(c2)c(Cc2ccccc2)c(C)n3C)cc1>>Cc1c(Cc2ccccc2)c2cc(-c3ccc(O)cc3)ccc2n1C,,ClCCl,,BrB(Br)Br,,val
US20100267688A1,CI.Nc1cccc(C2=CCC3(CC2)OCCO3)n1>>CNc1cccc(C2=CCC3(CC2)OCCO3)n1,,CN(C)C=O,,CO,[H-].[Na+],val
US20100125085A1,Cc1ccc2c(c1)c1c(n2C=Cc2ccc(C)nc2)CCN(C(=O)OC(C)(C)C)C1>>Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C(=O)OC(C)(C)C)C1,[Pd],CO,,,,val
US20120083513A1,CSCN=C=O.N#Cc1ccc(/C=C/C2=NC=NC2=[N+]=[N-])cc1>>CSCn1nnc2c(/C=C/c3ccc(C#N)cc3)ncn2c1=O,,CS(C)=O,,,,val
US20090275037A1,CI.Cc1nc2ccccc2s1>>Cc1sc2ccccc2[n+]1C.[I-],,CCO,,,,val
US06531599B2,CCOC(=O)c1ccc(C#Cc2ccc(C3(OCc4ccccc4)CC3)c(C)c2)cc1>>Cc1cc(C#Cc2ccc(C(=O)O)cc2)ccc1C1(Cc2ccccc2)CO1,,C1CCOC1,CCO,[Na+].[OH-],,val
US05118811,O=C1CCC(=O)O1.O=C1CCCN1>>O=C(O)CCC(=O)N1CCCC1=O,,C1CCOC1,,Cl,[Li]CCCC,val
US04996217,Cc1cc(C)nc(-n2ccnc2SCc2ccccc2N)c1.O=CO>>Cc1cc(C)nc(-n2ccnc2SCc2ccccc2NC=O)c1,,O=CO,,CC(=O)OC(C)=O,,val
US20110015157A1,CC1(c2ccccc2)CCN(c2ccnc(Cl)n2)C(=O)O1.OB(O)c1ccc(F)cc1>>CC1(c2ccccc2)CCN(c2ccnc(-c3ccc(F)cc3)n2)C(=O)O1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20100022544A1,CS(=O)(=O)Cl.OCc1cccc(-c2nnn[nH]2)c1>>CS(=O)(=O)OCc1cccc(-c2nnn[nH]2)c1,,ClCCl,,CCN(CC)CC,,val
US04315928,CCN(CC)SCl.CN=C=O.F>>CCN(CC)SN(C)C(=O)F,,CCN(CC)CC,,ClCCl,,val
US20090156603A1,CON(C)C(=O)C1CCN(C(=O)OC(C)(C)C)CC1C.C[Mg]Cl>>CC(=O)C1CCN(C(=O)OC(C)(C)C)CC1C,,C1CCOC1,,,,val
US20080009530A1,CC(C)OC(=O)Cl.CCCCOc1cc(CCS(N)(=O)=O)n(Cc2ccc(Cl)cc2Cl)n1>>CCCCOc1cc(CCS(=O)(=O)NC(=O)OC(C)C)n(Cc2ccc(Cl)cc2Cl)n1,CN(C)c1ccncc1,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20070105832A1,O=C(CCc1ccccc1)/N=C(\NCCC[C@H]1C(=O)N(C(=O)Nc2ccccc2)[C@@H]1C(=O)OCc1ccccc1)NC(=O)CCc1ccccc1>>N=C(N)NCCC[C@H]1C(=O)N(C(=O)Nc2ccccc2)[C@@H]1C(=O)O,[Pd],C1CCOC1,Cl,,,val
US04521419,Cc1ccc2nc3c(c(=O)n2c1)CCC3.O=Cc1ccccc1>>Cc1ccc2nc3c(c(=O)n2c1)CCC3=Cc1ccccc1,,CO,,C[O-].[Na+],,val
US07368458B2,CC(C)(C)OC(=O)Nc1ccc(Br)nc1.OB(O)c1ccccc1>>CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2)nc1,,C1CCOC1,O,CO,O=C([O-])[O-].[K+].[K+],val
US20070032485A1,CCOC(=O)N1c2ccc(OC)nc2[C@@H](N)C[C@H]1CC.C[C@H](O)c1ccccc1.O=C(n1ccnc1)n1ccnc1>>CCOC(=O)N1c2ccc(OC)nc2[C@@H](NC(=O)O[C@@H](C)c2ccccc2)C[C@H]1CC,,C1CCOC1,,CCN(CC)CC,,val
US20020156087A1,CCOCC.Clc1ccccn1.NC(=[NH2+])c1cccc2[nH]nnc12.NCCN.NCCNc1ccccn1>>NC(=O)c1ccc(-c2ccnc(NCCNc3ccccn3)n2)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080070935A1,NN.Nc1ncnc2cc(F)ccc12>>NNc1ccc2c(N)ncnc2c1,,CC(C)O,,,,val
US20050130954A1,C[C@H]1NC(=O)O[C@H]1c1ccccc1.O=C(Cl)CCc1ccc(Cl)cc1>>C[C@@H]1[C@H](c2ccccc2)OC(=O)N1C(=O)CCc1ccc(Cl)cc1,,C1CCOC1,,[Li]CCCC,,val
US20040102450A1,CC(C)(C)OC(=O)N1CCN(Cc2ccc3c(N)ncnc3c2)C(=O)C1>>Nc1ncnc2cc(CN3CCNCC3=O)ccc12,,CCOC(C)=O,,Cl,,val
US20120065164A1,Cn1nc(C(F)F)c(C(=O)N(Cc2ccccc2[Si](C)(C)C)C2CC2)c1F.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>Cn1nc(C(F)F)c(C(=S)N(Cc2ccccc2[Si](C)(C)C)C2CC2)c1F,,C1COCCO1,,O,,val
US20110021425A1,CC1CCCCN1CC#Cc1cnc2c(ccn2COCC[Si](C)(C)C)n1>>CC1CCCCN1c1ccc2cnc3c(ccn3COCC[Si](C)(C)C)n12,I[Cu]I,CC(=O)N(C)C,,C1CCC2=NCCCN2CC1,,val
US20030232860A1,O=C1OCCO1.O=Cc1cccc(O)c1>>O=Cc1cccc(OCCO)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04496572,Cc1c(Cc2cccnc2)sc2ccc(C#N)cc12.OO>>Cc1c(Cc2cccnc2)sc2ccc(C(N)=O)cc12,,CCO,,O,[Na+].[OH-],val
US20090099174A1,Cc1c(Cl)c(C(=O)O)nn(C)c1=O.Nc1ccc(Br)cc1F>>Cc1c(Nc2ccc(Br)cc2F)c(C(=O)O)nn(C)c1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20070281950A1,CO.O=[N+]([O-])C1=C2N(Cc3ccc(Cl)nc3)CCN2C(O)CC1>>COC1CCC([N+](=O)[O-])=C2N(Cc3ccc(Cl)nc3)CCN21,,CC(=O)O,,,,val
US20010008893A1,CC(=O)Oc1ccc(O)c(C)c1C.ClCC1CO1>>CC(=O)Oc1ccc(OCC2CO2)c(C)c1C,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040122057A1,Brc1ccncc1.CCOC(C(=O)NCc1ccc(C#N)cc1)c1c(F)cc(B2OC(C)(C)C(C)(C)O2)cc1F>>CCOC(C(=O)NCc1ccc(C#N)cc1)c1c(F)cc(-c2ccncc2)cc1F,,COCCOC,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US05523457,COC(=O)c1ccc2cccc(Br)c2c1>>O=C(O)c1ccc2cccc(Br)c2c1,,CCO,,Cl,[Na+].[OH-],val
US20070105904A1,Fc1ccc(CCl)nc1.Nc1ncccc1-c1cc(Cc2ccc(O)cc2)no1>>Nc1ncccc1-c1cc(Cc2ccc(OCc3ccc(F)cn3)cc2)no1,,CN(C)C=O,,C1CCOC1,[Na+].[OH-],val
US20070197553A1,CC(=O)O.CCO.Cc1cc(-c2ccc(F)cc2)cc(C#N)n1>>CCOC(=O)c1cc(-c2ccc(F)cc2)cc(C)n1,,[K+],[OH-],O,,val
US20150152118A1,O=C(OCc1ccccc1)[C@H]1CC[C@H](N2CCN(c3ccc(F)cc3)CC2)C1>>O=C(O)[C@H]1CC[C@H](N2CCN(c3ccc(F)cc3)CC2)C1,[Pd],CO,,,,val
US20090118312A1,COC(=O)c1ccc(OC)c(C)c1N.O=C(Cl)c1ccccc1>>COC(=O)c1ccc(OC)c(C)c1NC(=O)c1ccccc1,,ClCCl,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US20040198790A1,C=CCOP(=O)(OCC=C)OCc1c(C)cccc1C(=O)Cl.C[C@@H](S[C@H]1CO[C@H](/C=C/C=C/c2ccc(C#N)cc2F)OC1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F>>C=CCOP(=O)(OCC=C)OCc1c(C)cccc1C(=O)O[C@@](Cn1cncn1)(c1ccc(F)cc1F)[C@@H](C)S[C@H]1CO[C@H](/C=C/C=C/c2ccc(C#N)cc2F)OC1,,C1CCOC1,,[H-].[Na+],,val
US05808062,O=c1oc(-c2ccccc2)cc(O)c1C(CCc1ccccc1)Sc1ccccc1>>O=c1oc(-c2ccccc2)cc(O)c1CCCc1ccccc1,[Ni],CCO,,,,val
US20090209607A1,COC(=O)c1cc(-c2c(C)c(Cl)nn2C)cs1>>Cc1c(Cl)nn(C)c1-c1csc(C(=O)O)c1,,C1CCOC1,,[Na+].[OH-],,val
US04384123,[N-]=[N+]=NC1C[C@@H](C(=O)O)N(C(=O)CP(=O)(O)CCCCc2ccccc2)C1>>NC1C[C@@H](C(=O)O)N(C(=O)CP(=O)(O)CCCCc2ccccc2)C1,[Pd],O,,,,val
US05712267,CC(=N)NC(=O)OCc1ccc([N+](=O)[O-])cc1.COc1ccc(CS[C@H]2C[C@@H](C(=O)N3CCCNCC3)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1>>COc1ccc(CS[C@H]2C[C@@H](C(=O)N3CCCN(C(C)=NC(=O)OCc4ccc([N+](=O)[O-])cc4)CC3)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1,,CO,,Cl,ClCCl,val
US05364855,Cc1cccc2nnc(-c3ccccc3)c(O)c12.O=P(Cl)(Cl)Cl>>Cc1cccc2nnc(-c3ccccc3)c(Cl)c12,,O=P(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20090203663A1,COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1c(Cl)cccc1Cl.OC1CCN(c2ccccc2)CC1>>COC(=O)[C@H](Cc1ccc(OC2CCN(c3ccccc3)CC2)cc1)NC(=O)c1c(Cl)cccc1Cl,,ClCCl,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04486434,Cc1cc(Br)cnc1CCCCN.Cc1ccc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)cn1>>Cc1ccc(Cc2cnc(NCCCCc3ncc(Br)cc3C)[nH]c2=O)cn1,,c1ccncc1,,,,val
US04443473,CCOC(C)Oc1ccc(C#N)cc1OC>>CCOC(C)Oc1ccc(CN)cc1OC,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140350019A1,CCOC(=O)COc1ccc(C)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F>>Cc1ccc(OCC(=O)O)c(F)c1NCc1cc(-c2cccc(F)c2)ccc1F,,C1CCOC1,,[Na+].[OH-],,val
US20150210739A1,CC(C)(C)OC(=O)N[C@H](C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F)C1CCCCC1.O=C(O)C(F)(F)F>>N[C@H](C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F)C1CCCCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20150119378A1,CC(C)(C)OC(=O)N1CC(Br)=CC(O[C@@H]2CCNC2)=C1Cl>>Clc1ncc(Br)cc1O[C@@H]1CCNC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090137561A1,CCC(C)(CC(=O)OC)c1cccc(OCc2ccccc2)c1>>CCC(C)(CC(=O)OC)c1cccc(O)c1,[Pd],CO,,,,val
US20090124695A1,C=C1C[C@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)[C@H](C/C=C\CCCC(=O)OC)[C@H]1/C=C/C(C)(CCCCC)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C>>C=C1C[C@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)[C@H](C/C=C\CCCC(=O)O)[C@H]1/C=C/C(C)(CCCCC)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,CCOC(C)=O,,CO,[Li+].[OH-],val
US20050075378A1,CC(C)(C)OC(=O)CCc1ccc(OCCCOc2ccc(-c3ccccc3)cc2)cc1COC(=O)NC1CCCCC1>>O=C(O)CCc1ccc(OCCCOc2ccc(-c3ccccc3)cc2)cc1COC(=O)NC1CCCCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05994355,N#CC(c1ccc(Cl)c(Cl)c1)c1c(Cl)cc([N+](=O)[O-])cc1Cl>>N#CC(c1ccc(Cl)c(Cl)c1)c1c(Cl)cc(N)cc1Cl,[Ni],CO,,[H][H],,val
US20040138208A1,CC(C)(C)OC(=O)ONCCC1CCNCC1.Clc1ccncc1>>CC(C)(C)OC(=O)ONCCC1CCN(c2ccncc2)CC1,,CCO,,Cl,,val
US20070197626A1,CCOC(=O)Cc1cccc(OCCN2CC(C)(C)c3cc(-c4ccc(C(F)(F)F)cc4)ccc32)c1.Cl>>CC1(C)CN(CCOc2cccc(CC(=O)O)c2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc21.Cl,,CCO,,[Na+].[OH-],,val
US20130281438A1,O=[N+]([O-])c1cccc2c1ccn2CCCN1CCOCC1>>Nc1cccc2c1ccn2CCCN1CCOCC1,[Pd],CO,,,,val
US04831041,C#CCc1c(C)nc2c(OCc3c(CO)cccc3CO)cccn12.Cl>>C#CCc1c(C)nc2c(OCc3c(CO)cccc3CO)cccn12.Cl,,CO,,,,val
US05008267,C1CCOC1.COC(=O)c1ccc(O)c([N+](=O)[O-])c1.Cn1c(NCCNC(=O)c2ccc([N+](=O)[O-])cc2)cc(=O)n(C)c1=O>>COC(=O)c1ccc(OCCCN2CCN(c3cc(=O)n(C)c(=O)n3C)CC2)c([N+](=O)[O-])c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140100231A1,COc1ccc(Cn2nc(CO)cc(-c3ccc(F)cc3)c2=O)cc1.CS(=O)(=O)Cl>>COc1ccc(Cn2nc(CCl)cc(-c3ccc(F)cc3)c2=O)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090143448A1,BrBr.CCc1csc(N)n1>>CCc1nc(N)sc1Br,,O=S(=O)(O)O,,,,val
US20150111866A1,Cc1cc(C(=O)O)ccc1-c1nc(C)c(-c2cnc(S(C)(=O)=O)nc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)s1.FC1(F)CNC1>>Cc1cc(C(=O)O)ccc1-c1nc(C)c(-c2cnc(N3CC(F)(F)C3)nc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)s1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080306066A1,CC(C)N1CCN(C(=O)c2ccc(CN3CCCCC3)nc2)CC1.CC(C)N1CCNCC1.COC(=O)c1ccc(CN2CCCCC2)nc1>>CC(C)N1CCN(C(=O)c2ccc(CN3CCCCC3)nc2)CC1.N,,C1CCOC1,,,,val
US20130281392A1,Nc1cc(Cl)c(-c2ccc(C(F)(F)F)cc2)cc1N.O=C(O)C(F)(F)C(F)(F)C(F)(F)F>>FC(F)(F)c1ccc(-c2cc3[nH]c(C(F)(F)C(F)(F)C(F)(F)F)nc3cc2Cl)cc1,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20140205537A1,CCOC(OCC)C(=O)CC(C)=O.NN>>CCOC(OCC)c1cc(C)n[nH]1,,[Na+],[OH-],O=S(=O)(O)O,,val
US20160152621A1,COS(=O)(=O)OC.O=[N+]([O-])c1ccc(Br)c(O)c1>>COc1cc([N+](=O)[O-])ccc1Br,,C1CCOC1,,[Li+].[OH-],,val
US04069381,C=CC.CC(=O)O.CC(=O)OC(C)=O>>CC(=O)OCC(C)OC(C)=O,,CC(=O)OC(C)=O,,O=O,,val
US20110230458A1,CCCCc1nnc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1-c1ccc(OC2CCCCC2)c(-c2cn[nH]c2)c1.COCCBr>>CCCCc1nnc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1-c1ccc(OC2CCCCC2)c(-c2cnn(CCOC)c2)c1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US04045439,CCOC(=O)c1nnc2ccc(N)cc2c1O.COC(=O)C(Cc1ccccc1)N=C=O>>CCOC(=O)c1nnc2ccc(NC(=O)NC(Cc3ccccc3)C(=O)OC)cc2c1O,,c1ccncc1,,,,val
US05486517,CN(C)C=O.ClCCCCOc1ccc(-c2nc3ccccc3[nH]2)cc1.c1ccc(N2CCNCC2)cc1>>N.c1ccc(N2CCN(CCCCOc3ccc(-c4nc5ccccc5[nH]4)cc3)CC2)cc1,,CN(C)C=O,,,,val
US20060205772A1,C1CCNC1.CC1(C)CCC(=O)CC1>>CC1(C)CC=C(N2CCCC2)CC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110275611A1,CNc1nc(-c2ccc(C#N)c(F)c2)cc(N2C[C@@H](C(=O)O)OC[C@H]2C)n1.NCc1ccccc1>>CNc1nc(-c2ccc(C#N)c(F)c2)cc(N2C[C@@H](C(=O)NCc3ccccc3)OC[C@H]2C)n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100144710A1,CC(Br)C(=O)OC(C)(C)C.CCCCc1ccc(NC)cc1>>CCCCc1ccc(N(C)C(C)C(=O)OC(C)(C)C)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05633248,CCOC(=O)CCC(CCC#N)(c1ccccc1)c1ccccc1>>N#CCCC(CCC(=O)O)(c1ccccc1)c1ccccc1,,CCO,,[Na+].[OH-],,val
US05008267,Brc1ccccn1.N#Cc1ccc(Cl)cc1.O=S(=O)(O)O.O=[N+]([O-])O>>O=C(c1ccc(Cl)c([N+](=O)[O-])c1)c1ccccn1,,O=S(=O)(O)O,,CCOCC,[Li]CCCC,val
US20040122057A1,CCOC(=O)CBr.CCOC(C(=O)NCc1ccc(C#N)cc1)c1ccc(OC)c(O)c1>>CCOC(=O)COc1cc(C(OCC)C(=O)NCc2ccc(C#N)cc2)ccc1OC,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US05656197,C=CCBr.C=CCOCCOCCOc1ccc(C(=O)OC)cc1.O=C([O-])c1ccc(OCCOCCO)cc1>>C=CCOCCOCCOCCOc1ccc(C(=O)OC)cc1,,C1CCOC1,O,[H][H],[H-].[Na+],val
US20100021423A1,COc1c(NC(=O)c2ccc(Cl)nn2)cc(-c2cccnc2OCc2ccccc2)cc1C(C)(C)C.NCC(F)(F)F>>COc1c(NC(=O)c2ccc(NCC(F)(F)F)nn2)cc(-c2cccnc2OCc2ccccc2)cc1C(C)(C)C,,CN1CCCC1=O,,O,,val
US20060084663A1,Cc1cc(OCCc2nc(-c3ccc(-c4ccccc4F)nc3)sc2C)ccc1CCC(=O)OC(C)(C)C>>Cc1cc(OCCc2nc(-c3ccc(-c4ccccc4F)nc3)sc2C)ccc1CCC(=O)O,O,ClCCl,,O=C(O)C(F)(F)F,,val
US20160108036A1,C1CCNC1.CCOC(=O)c1cn(Cc2cnc(Cl)c(OC)c2)nc1C1CC1>>CCOC(=O)c1cn(Cc2cnc(N3CCCC3)c(OC)c2)nc1C1CC1,,C1COCCO1,CCOC(C)=O,O=C([O-])O.[Na+],,val
US20120277224A1,CN=C=O.Cc1nn2c(=O)cc(-c3ccc(O)cc3)[nH]c2c1-c1ccccn1>>CNC(=O)Oc1ccc(-c2cc(=O)n3nc(C)c(-c4ccccn4)c3[nH]2)cc1,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US20020198197A1,Cc1cc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])cc1C(F)(F)F>>Cc1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F,[Pd],,,,,val
US20020156081A1,CCC=C1CC(O)C1.CS(=O)(=O)Cl>>CCC=C1CC(OS(C)(=O)=O)C1,,c1ccncc1,,,,val
US20060199806A1,COc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)C(Cl)(Cl)Cl)n3Cc3ccccc32)cc1C.NCCc1ccc(O)cc1>>COc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)NCCc4ccc(O)cc4)n3Cc3ccccc32)cc1C,,CS(C)=O,,O,,val
US20130065883A1,CCOC(=O)c1cc2nnn(-c3ccc(OC)cc3)c2nc1OS(=O)(=O)C(F)(F)F.CN1CCC(CN)CC1>>CCOC(=O)c1cc2nnn(-c3ccc(OC)cc3)c2nc1NCC1CCN(C)CC1,,c1ccncc1,,,,val
US20120128630A1,CC(=O)c1ccc(S(C)(=O)=O)cc1.CCOC(=O)C(=O)OCC>>CCOC(=O)C(=O)CC(=O)c1ccc(S(C)(=O)=O)cc1,,CCOC(C)=O,,C,C[O-].[Na+],val
US20080181866A1,O=C(Cl)OCc1ccccc1.O=C(O)[C@@H]1C[C@@H](Cc2ccccc2)CN1>>O=C(O)[C@@H]1C[C@@H](Cc2ccccc2)CN1C(=O)OCc1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20120329784A1,CNS(=O)(=O)c1cc(Cl)cc([N+](=O)[O-])c1>>CNS(=O)(=O)c1cc(N)cc(Cl)c1,,CCO,,Cl[Sn]Cl,,val
US06552225B1,C[C@@](O)(C(=O)Nc1cccc([N+](=O)[O-])c1Cl)C(F)(F)F>>C[C@@](O)(C(=O)Nc1cccc(N)c1Cl)C(F)(F)F,[Pd],CCOC(C)=O,,,,val
US20140228343A1,O=[N+]([O-])c1ccc(Br)cc1NCc1ccccc1>>Nc1ccc(Br)cc1NCc1ccccc1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20120295884A1,NC(=O)n1cc(N=C=O)c2ccccc21.O=C(N[C@@H]1CN[C@H](C(=O)OCc2ccccc2)C1)OCC1c2ccccc2-c2ccccc21>>NC(=O)n1cc(NC(=O)N2C[C@@H](NC(=O)OCC3c4ccccc4-c4ccccc43)C[C@H]2C(=O)OCc2ccccc2)c2ccccc21,,C1CCOC1,,CCN(CC)CC,O,val
US20150353530A1,CS(=O)(=O)Cl.Clc1ccc([C@]2(Cn3ccnc3)OC[C@@H](COc3ccc(N4CCNCC4)cc3)O2)c(Cl)c1>>CS(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20100063078A1,Cc1nc(C)c(-c2nnc(S)n2C)s1.ClCCCBr>>Cc1nc(C)c(-c2nnc(SCCCCl)n2C)s1,,CC(C)=O,CCOC(C)=O,CO,O=C([O-])[O-].[K+].[K+],val
US03947452,C=O.O=C1NC(=O)c2cccc3cccc1c23.c1ccc2c(c1)CCNC2>>O=C1c2cccc3cccc(c23)C(=O)N1CN1CCc2ccccc2C1,,CN(C)C=O,,,,val
US04713393,OCc1ccccc1/C=C/Cc1cc2c(cc1O)CCO2>>OCc1ccccc1CCCc1cc2c(cc1O)CCO2,O=[Pt]=O,CC(=O)O,CCOCC,CCO,,val
US20120149723A1,C=C[C@@H]1CC[C@H](C)CN1C(=O)OC(C)(C)C.OO>>C[C@H]1CC[C@@H](CCO)N(C(=O)OC(C)(C)C)C1,,C1CCOC1,CCOCC,O,[Na+].[OH-],val
US20090005353A1,CC(C)N1C(=O)C(Cl)=C(c2ccccc2)S1(=O)=O.N#Cc1ccc(CCN)cc1>>CC(C)N1C(=O)C(NCCc2ccc(C#N)cc2)=C(c2ccccc2)S1(=O)=O,,CC#N,,,,val
US20070265264A1,CI.O=[N+]([O-])c1ccc(CNC[C@H]2CCCO2)cc1>>CN(Cc1ccc(N)cc1)C[C@H]1CCCO1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090137557A1,Cc1ncc(-c2c(C)nc(-c3cccc(F)c3OCc3ccccc3)n(CCc3ccccc3)c2=O)s1>>Cc1ncc(-c2c(C)nc(-c3cccc(F)c3O)n(CCc3ccccc3)c2=O)s1,,CC(=O)O,,Br,,val
US20070276000A1,COc1ccc2c(OC(C)=O)c(-c3ccccc3)c(C)cc2c1>>COc1ccc2c(O)c(-c3ccccc3)c(C)cc2c1,,C1CCOC1,CO,C[O-].[Na+],,val
US20100099684A1,CCOC(OCC)C(=N)OC.NCc1cccc(Cl)c1F>>CCOC(OCC)C(=N)NCc1cccc(Cl)c1F,,CO,,,,val
US20160159774A1,O=C(N1Cc2ccc([N+](=O)[O-])cc2C1)C(F)(F)F>>O=[N+]([O-])c1ccc2c(c1)CN(CC(F)(F)F)C2,,C1CCOC1,,,,val
US06380238B1,Cc1cc(F)c(N)cc1[N+](=O)[O-].[I-]>>Cc1cc(F)c(I)cc1[N+](=O)[O-],,Cl,O,O=N[O-].[Na+],,val
US20040034038A1,COCCNCCOC.O=[N+]([O-])c1cc(Cl)ccc1F>>COCCN(CCOC)c1ccc(Cl)cc1N,[Ni],CC#N,,[H][H],,val
US20080318978A2,C1CCC2=NCCCN2CC1.O=P(Cl)(Cl)Cl.c1ccncc1>>O=C1NCCC1=C1CCCn2cncc21,,ClCCl,,O,,val
US05227503,CCCCCCCCCCCCCC=CCC(O)C(=O)OC>>CCCCCCCCCCCCCC=CCC(O)C(=O)O,,CO,O,[Na+].[OH-],,val
US20150210652A1,CC(C)(C)[Mg]Cl.Clc1nc(Cl)nc(Cl)n1>>CC(C)(C)c1nc(Cl)nc(Cl)n1,[Cu]I,C1CCOC1,,[Cl-].[NH4+],,val
US20090324581A1,COC(=O)c1ccc(C2CCC2)c(C(F)(F)F)c1>>OCc1ccc(C2CCC2)c(C(F)(F)F)c1,,C1CCOC1,,Cl,[BH4-].[Li+],val
US20100210452A1,COC(=O)/C=C/C(=O)c1ccccc1.O=CCCc1ccccc1Cl>>COC(=O)[C@H]1C=C(c2ccccc2)OC(=O)[C@H]1Cc1ccccc1,,ClC(Cl)Cl,,,,val
US20120329784A1,CNS(=O)(=O)c1cc([N+](=O)[O-])ccc1F>>CNS(=O)(=O)c1cc(N)ccc1F,[Pd],CO,,,,val
US04091220,CN1CCNCC1.O=[N+]([O-])c1ccccc1CCl>>CN1CCN(Cc2ccccc2[N+](=O)[O-])CC1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20060211730A1,CCOC(=O)C1(NS(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2)CCN(C(C)=O)CC1>>CC(=O)N1CCC(NS(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2)(C(=O)O)CC1,,C1COCCO1,,Cl,,val
US20120035168A1,COC(=O)COc1cc(N)nc(C)c1CN.O=C(O)c1cnn(Cc2ccccc2)c1>>COC(=O)COc1cc(N)nc(C)c1CNC(=O)c1cnn(Cc2ccccc2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140018373A1,CCSc1cc(C(F)(F)F)ccc1-c1nc2cc(SC(F)(F)F)cnc2n1C.O=C(OO)c1cccc(Cl)c1>>CCS(=O)(=O)c1cc(C(F)(F)F)ccc1-c1nc2cc(SC(F)(F)F)cnc2n1C,,ClC(Cl)Cl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20100273764A1,COc1ccc(CN(Cc2ccc(OC)cc2)c2cc(-c3cc([C@@H](C)N4CCN(S(C)(=O)=O)CC4)cnc3F)nc(C)n2)cc1.COc1ncc(N)cc1F>>COc1ccc(CN(Cc2ccc(OC)cc2)c2cc(-c3cc([C@@H](C)N4CCN(S(C)(=O)=O)CC4)cnc3Nc3cnc(OC)c(F)c3)nc(C)n2)cc1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20050096380A1,C1CCOC1.CCOc1c(C(C)=O)cc2c(c1Br)C(C)(C)CC=C2C(C)C>>CCOc1c(C(=O)CC)cc2c(c1Br)C(C)(C)CC=C2C(C)C,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20090221555A1,O=C(CN1CCCC1)N1CCCOc2ccc([N+](=O)[O-])cc21>>Nc1ccc2c(c1)N(C(=O)CN1CCCC1)CCCO2,[Pd],C1CCOC1,CCO,,,val
US20150045378A1,CC(C)CBr.COC(=O)c1cncc(O)c1>>COC(=O)c1cncc(OCC(C)C)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070185183A1,CC1(C)CN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)c2ccc(Br)cc21.OB(O)c1ccc(C(F)(F)F)cc1>>CC1(C)CN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20020103229A1,N#Cc1ccc2c(c1)c(/C=C/c1ccccc1)nn2C1CCCCO1>>N#Cc1ccc2[nH]nc(/C=C/c3ccccc3)c2c1,,C1CCOC1,Cl,,,val
US20150126484A1,C[Si](C)(C)C#N.Nc1ncnc(N2CCNCC2)c1-c1ccc(F)cc1.O=Cc1cccc(C(F)(F)F)c1>>N#CC(c1cccc(C(F)(F)F)c1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1,,CC#N,,,,val
US20160000929A1,C#CCC(CO)CC#C.CC(C)OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1>>C#CCC(CC#C)COC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090143353A1,CCOC(=O)[C@@H]1C[C@H]1c1nc2c(C#N)c(C)c(-c3ccccc3)c(F)c2o1.CN(C)[C@H]1CCNC1>>CCOC(=O)[C@@H]1C[C@H]1c1nc2c(C#N)c(C)c(-c3ccccc3)c(N3CC[C@H](N(C)C)C3)c2o1,,CS(C)=O,,CCN(CC)CC,,val
US20130190312A1,COc1cnc(S)cn1.Cc1cc(I)cc(C)c1-c1csc(NC(=O)c2ccncc2)n1>>COc1cnc(Sc2cc(C)c(-c3csc(NC(=O)c4ccncc4)n3)c(C)c2)cn1,I[Cu]I,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110294829A1,BrCCC1CCCCC1.CC(C)(C)OC(=O)Nc1cccc(CO)n1>>CCCCCCN(C(=O)OC(C)(C)C)c1cccc(CO)n1,,CN(C)C=O,O,CC(C)(C)[O-].[K+],,val
US20030187021A1,CN1CCC(Cl)CC1.O=C(c1ccccc1)c1ccccc1>>CN1CCC(C(O)(c2ccccc2)c2ccccc2)CC1,,C1CCOC1,,,,val
US20040082570A1,CC(C)(C)OC(=O)N1CC(OS(C)(=O)=O)CC1CO.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CC(OS(C)(=O)=O)CC1COS(C)(=O)=O,,CCOC(C)=O,c1ccncc1,,,val
US20130184257A1,CS(=O)(=O)c1cc(F)c(O[C@H]2CCN(C3CCN(C#N)CC3)C2=O)cc1F.NO>>CS(=O)(=O)c1cc(F)c(O[C@H]2CCN(C3CCN(C(=N)NO)CC3)C2=O)cc1F,,CCO,,,,val
US04371720,C=CCC1C=CC(=O)CC1.C[Cu]C>>C=CC[C@@H]1CCC(=O)C[C@H]1C,,C1CCOC1,,[Li],,val
US20090029986A1,CC(C)(C)OC(=O)N1CCCC[C@H]1CN.ClN1CC=Nc2ccccc21>>CC(C)(C)OC(=O)N1CCCCC1CNc1ncnc2ccccc12,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20140349989A1,Cc1ccc(S(=O)(=O)OC2CN(C(=O)OC(C)(C)C)C2)cc1.Ic1n[nH]c2ccccc12>>CC(C)(C)OC(=O)N1CC(n2nc(I)c3ccccc32)C1,,CN(C)C=O,,O,[H-].[Na+],val
US06133279,CC(=O)Oc1c(C(C)(C)C)cc2c(c1C(C)(C)C)CC(C)(CI)O2.[C-]#N>>CC1(CC#N)Cc2c(cc(C(C)(C)C)c(O)c2C(C)(C)C)O1,,CS(C)=O,,O,,val
US20090270454A1,CC(C)(C)c1cc(SC2CCNCC2)cc(C(C)(C)C)c1O.COC(=O)c1ccc(S(=O)(=O)Cl)o1>>COC(=O)c1ccc(S(=O)(=O)N2CCC(Sc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)CC2)o1,,ClCCl,,CCN(CC)CC,Cl,val
US20060264429A1,Cc1ccc2c(N3CCN(CCC(O)c4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1.Cl>>Cc1ccc2c(N3CCN(C/C=C/c4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1.Cl,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20160009666A1,CC(C)(C)OC(=O)Nc1ccc(CNc2nc(Nc3cc(Cl)cc(Cl)c3)n[nH]2)cn1>>Nc1ccc(CNc2nc(Nc3cc(Cl)cc(Cl)c3)n[nH]2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060135578A1,CCN=C=NCCCN(C)C.CCOP(=O)(/C=C/c1cn(-c2ccccc2)nc1OCc1ccc(OCc2nc(-c3ccc(C(=O)O)cc3)oc2C)c(OC)c1)OCC>>CCOP(=O)(/C=C/c1cn(-c2ccccc2)nc1OCc1ccc(OCc2nc(-c3ccc(C(N)=O)cc3)oc2C)c(OC)c1)OCC,,O,,CN(C)C=O,Cl,val
US20140248268A1,CC(C)(C)OC(=O)c1c(N)sc2c1CC(C)(C)OC2.COc1cccc(C(=O)N=C=S)c1>>COc1cccc(C(=O)NC(=S)Nc2sc3c(c2C(=O)OC(C)(C)C)CC(C)(C)OC3)c1,,C1CCOC1,,,,val
US07893278B2,CCOc1ccccc1C1=N[C@@H](c2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)N1C(=O)Cl.CS(=O)(=O)CCN1CCNCC1>>CCOc1ccccc1C1=N[C@@H](c2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)N1C(=O)N1CCN(CCS(C)(=O)=O)CC1,,ClCCl,,Cl,Cl,val
US05438052,CC(C)(ON)C(=O)NNC(=O)c1ccc(O)c(O)c1.Nc1nc(C(=O)C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(CSc4cc(-c5ccc(O)c(O)c5)nc5ccnn45)CS[C@H]23)cs1>>CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3cc(-c4ccc(O)c(O)c4)nc4ccnn34)CS[C@H]12)c1csc(N)n1)C(=O)NNC(=O)c1ccc(O)c(O)c1,,CC(=O)N(C)C,,Cl,,val
US05123951,CCOC(=O)C1(C(=O)Nc2cc(Cl)c(Cl)cc2C)CC1>>Cc1cc(Cl)c(Cl)cc1NC(=O)C1(C(=O)O)CC1,,CCO,O,[K+].[OH-],,val
US20050059678A1,CC(=O)O.Nc1ccc([N+](=O)[O-])cc1O>>CC(=O)Nc1ccc([N+](=O)[O-])cc1O,,O,,CC(=O)OC(C)=O,,val
US08609696B2,NO.O=C(c1ccc(-c2ccccc2F)cc1)N1CCC(Cc2nc(C(F)(F)F)c[nH]2)CC1>>N#Cc1c[nH]c(CC2CCN(C(=O)c3ccc(-c4ccccc4F)cc3)CC2)n1,,CC#N,,,,val
US20100168113A1,COc1cc(-c2ncnc(-c3cccnc3C(F)(F)F)n2)cc([N+](=O)[O-])c1OC>>O=[N+]([O-])c1cc(-c2ncnc(-c3cccnc3C(F)(F)F)n2)cc(O)c1O,,ClCCl,,BrB(Br)Br,,val
US05332734,Cc1cccc(NC(=O)[C@H](CC(C)C)NC(=O)OCC2c3ccccc3-c3ccccc32)c1C(=O)O>>Cc1cccc2nc([C@H](CC(C)C)NC(=O)OCC3c4ccccc4-c4ccccc43)oc(=O)c12,,CCOC(C)=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20050222155A1,Clc1nc2ncccc2cc1-c1ccccc1.O=Cc1ccc(B(O)O)cc1>>O=Cc1ccc(-c2nc3ncccc3cc2-c2ccccc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20140256740A1,CCc1noc(C)c1CO.O=S(Cl)Cl>>CCc1noc(C)c1CCl,,ClCCl,,,,val
US20090186911A1,COc1cc(N)c(C(=O)O)cc1Br.c1ncncn1>>COc1cc2nc[nH]c(=O)c2cc1Br,,CO,,C1CCNCC1,,val
US20080318923A1,BrCc1ccccc1.CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)O>>CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)OCc1ccccc1,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20110136778A1,COC(=O)C1(CCCNCc2ccccc2)CCCN1>>O=C1N(Cc2ccccc2)CCCC12CCCN2,,Cc1ccccc1C,,,,val
US20160016903A1,CCOC(=O)CC1(C[N+](=O)[O-])CCC(c2ccccc2)(N2CCC2)CC1>>O=C1CC2(CCC(c3ccccc3)(N3CCC3)CC2)CN1,[Fe],CCO,,O,[Cl-].[NH4+],val
US20160096839A1,C=CC[C@H](NC(=O)OC(C)(C)C)c1cc(-c2c(NC(=O)[C@H](C)C=C)cnn2C)ccn1>>C[C@@H]1C=CC[C@H](NC(=O)OC(C)(C)C)c2cc(ccn2)-c2c(cnn2C)NC1=O,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,ClCCCl,,,,val
US04730055,CN1C(=O)c2ccc(Cl)cc2C1=O.CO[Si](C)(C)[Si](C)(C)OC>>CO[Si](C)(C)c1ccc2c(c1)C(=O)N(C)C2=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US04996218,Brc1ccc2ccccc2n1.C#CCCCCOCCCCCCBr>>BrCCCCCCOCCCCC#Cc1ccc2ccccc2n1,[Cu]I,CC#N,CCOCC,,,val
US20150210720A1,CCOC(=O)CCNC(=O)CC(=O)OCC>>CCOC(=O)C1C(=O)CCNC1=O,,CCO,,Cl,[Na],val
US20110028442A1,CC(Cc1cccc(NC(=O)Nc2ccccc2-c2ccccc2)c1)NC[C@H](O)c1ccc2c(c1)COC(C)(C)O2>>CC(Cc1cccc(NC(=O)Nc2ccccc2-c2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1,,CC(=O)O,O,,,val
US20060009456A1,C=CCOc1ccc(C=CC(=O)CC2CN(c3ccc(Cl)c(OC)c3)CCN2C(=O)OC(C)(C)C)c(C)c1C.Cl>>C=CCOc1ccc(C=CC(=O)CC2CN(c3ccc(Cl)c(OC)c3)CCN2)c(C)c1C.Cl,,CO,,,,val
US20030224283A1,C=C(C)C(=O)Cl.OCCCC(O)(C(F)(F)F)C(F)(F)F>>C=C(C)C(=O)OCCCC(O)(C(F)(F)F)C(F)(F)F,,C1CCOC1,CCOCC,[Li]CCCC,,val
US05430062,COc1ccc(C2Cc3cc(OC)c(OC)c(OC)c3C2=O)cc1>>COc1ccc(C2Cc3cc(OC)c(OC)c(OC)c3C2)cc1,[Pd],CC(=O)O,,,,val
US20120022123A1,CCO.O=C(O)c1cc(Br)cs1>>CCOC(=O)c1cc(Br)cs1,,O,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20150274777A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)C(=O)NCc1ccccc1>>C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCc1ccccc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20080255083A1,O=C(N1CCc2ccc(CCn3ccc(OCc4ccc(F)cn4)cc3=O)cc2CC1)C(F)(F)F>>O=c1cc(OCc2ccc(F)cn2)ccn1CCc1ccc2c(c1)CCNCC2,,CO,,[Na+].[OH-],,val
US06140051,CC(=O)Nc1ccc(CCOC(C)=O)cc1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CC(=O)OCCc1ccc(NC(C)=S)cc1,,Cc1ccccc1,,,,val
US20140187545A1,CCOC(=O)C(C#N)Cc1cccc(Cl)c1Cl.NN>>Nc1n[nH]c(O)c1Cc1cccc(Cl)c1Cl,,CCO,,O,,val
US20140200227A1,CC(C)(C)OC(=O)N[C@@H]1CNC[C@H](C2CC2)[C@H]1O.O=[N+]([O-])c1cnc2c(c1Cl)CCC2>>CC(C)(C)OC(=O)N[C@@H]1CN(c2c([N+](=O)[O-])cnc3c2CCC3)C[C@H](C2CC2)[C@H]1O,,CC(C)O,,CCN(CC)CC,,val
US04760179,C=CC(=O)NC(C)(C)CC(C)(C)C.CCN(O)CC>>CCN(CC)OCCC(=O)NC(C)(C)CC(C)(C)C,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20070219229A1,COC(=O)c1cnc(Cl)c2ccn(C)c12>>Cn1ccc2c(Cl)ncc(C(=O)O)c21,,CO,,[Na+].[OH-],,val
US20060276464A1,CN(CCNS(=O)(=O)c1cc(S(=O)(=O)c2ccccc2)ccc1C(F)(F)F)C(=O)N(C)C1CCN(C(=O)OC(C)(C)C)CC1.Cl>>CN(CCNS(=O)(=O)c1cc(S(=O)(=O)c2ccccc2)ccc1C(F)(F)F)C(=O)N(C)C1CCNCC1.Cl,,CCOC(C)=O,,,,val
US05908860,CC1(C)Oc2ccc(C#N)cc2[C@@H](N)[C@@H]1O.O=C(Cl)c1ccc(Cl)cc1>>CC1(C)Oc2ccc(C#N)cc2[C@@H](NC(=O)c2ccc(Cl)cc2)[C@@H]1O,,ClCCl,,CCN(CC)CC,,val
US20130267510A1,CCOC(=O)C(=O)Cl.COCOc1ccc(C)c(OCOC)c1>>CCOC(=O)C(=O)c1c(OCOC)ccc(C)c1OCOC,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20110178064A1,CC(=O)OC(C)=O.C[C@@H]1CN2c3ncc(C(=N)NO)cc3CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1>>Cc1nc(-c2cnc3c(c2)CC2(C(=O)NC(=O)NC2=O)[C@H]2[C@H](C)O[C@H](C)CN32)no1,,C1COCCO1,,,,val
US20090111692A1,Cc1ccc(C(=N)N)nc1Br.N[NH3+].O=C1CCCCC1=O>>Cc1ccc(-c2nnc3c(n2)CCCC3)nc1Br,,CCO,,Cl,,val
US20090203647A1,CN(C)C=Nc1nc(O)ncc1F.O=C(Cl)c1ccccc1>>CN(C)C=Nc1nc(OC(=O)c2ccccc2)ncc1F,,c1ccncc1,,,,val
US05210092,C=Cc1cc(C#N)n(-c2ccc(CO)cc2)c1.CS(=O)(=O)Cl>>C=Cc1cc(C#N)n(-c2ccc(CCl)cc2)c1,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20160207905A1,CC(C)(C)OC(=O)NC1CCCC(CN2C(=O)c3ccccc3C2=O)C1>>CC(C)(C)OC(=O)NC1CCCC(CN)C1,,CCO,CCOC(C)=O,NN,O,val
US20100267712A1,CC(C)n1ccc2cc([N+](=O)[O-])ccc21>>CC(C)n1ccc2cc(N)ccc21,O=[Pt]=O,C1CCOC1,,,,val
US20090318408A1,CCN1CCC(N)CC1.Nc1ccc(C(=O)On2nnc3ccccc32)cc1>>CCN1CCC(NC(=O)c2ccc(N)cc2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20040220223A1,CN(C)C=O.Cl.O=C(c1ccccc1)N1CCCC(CCCN2CCC(C(=O)N3CCCC3)CC2)(c2ccc(Cl)c(Cl)c2)C1>>Cl.N#CC1(Cc2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1.O,,CN(C)C=O,,Cl,,val
US20110269761A1,C1COCCN1.CC(C)(C)OC(=O)CN(c1ccc2c(-c3noc(CCl)n3)cccc2c1)S(=O)(=O)c1cc(Cl)cc(Cl)c1>>CC(C)(C)OC(=O)CN(c1ccc2c(-c3noc(CN4CCOCC4)n3)cccc2c1)S(=O)(=O)c1cc(Cl)cc(Cl)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US05284847,CC(C)c1csc(NC(=O)OC(C)(C)C)c1NC(=O)OC(C)(C)C.CCOC(=O)C(=O)OCC>>CC(C)c1csc2[nH]c(=O)c(=O)[nH]c12,,CC(=O)O,,,,val
US20110053952A1,CC1(C)OB(c2ccc(OC(F)F)cc2)OC1(C)C.Clc1ncc(Br)cn1>>FC(F)Oc1ccc(-c2cnc(Cl)nc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20090082372A1,CCOC(=O)C(N)Cc1n[nH]c2cccc(F)c12>>NC(CO)Cc1n[nH]c2cccc(F)c12,,C1CCOC1,CCO,[BH4-].[Li+],,val
US04639468,CCCCCCN.N#CCO>>CCCCCCNCC#N,,CO,,,,val
US20160083361A1,C=CCOC(=O)N1CCc2c(c(=O)oc3c(C(=O)O)c(OCOC)ccc23)C1>>C=CCOC(=O)N1CCc2c(c(=O)oc3c(C(=O)O)c(O)ccc23)C1,,CO,,Cl,,val
US20030199440A1,COC(=O)[C@@H](C)N.O=S(=O)(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>COC(=O)[C@@H](C)NS(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1,,ClCCl,,CCN(CC)CC,,val
US20140030221A1,CC(=O)O[C@H](C)c1ccc2ccc(/C=C/C(C)(C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N3CCC[C@@H](C(=O)OCC(Cl)(Cl)Cl)N3)[C@@H](C)O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)C(C)C)cc2n1>>CC(C)[C@H](NC(=O)C(C)(C)/C=C/c1ccc2ccc([C@@H](C)O)nc2c1)C(=O)N[C@H](C(=O)N1CCC[C@@H](C(=O)O)N1)[C@@H](C)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20100311966A1,CCOC(=O)c1cnc(N2Cc3ccc(NC(=O)c4nc(Cl)c(CC)[nH]4)cc3C2)s1>>CCc1[nH]c(C(=O)Nc2ccc3c(c2)CN(c2ncc(C(=O)O)s2)C3)nc1Cl,,ClCCl,,CO,[Li+].[OH-],val
US20130102576A1,CC(C)(C)OC(=O)CBr.CN(C)S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2>>CN(C)S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CC(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20150094296A1,CC(C)[C@]1(C#N)CCN(c2ccnc(Nc3ccc(C4(C(=O)OC(C)(C)C)CCOCC4)cc3)n2)C1=O.Cl>>CC(C)[C@]1(C#N)CCN(c2ccnc(Nc3ccc(C4(C(=O)O)CCOCC4)cc3)n2)C1=O.Cl,,O,,,,val
US05298649,CC(=O)OC(C)=O.CCc1cccc2c(/C=C(\C)C(=O)O)cc(OC)c(O)c12>>CCc1cccc2c(/C=C(/C)C(=O)O)cc(OC)c(OC(C)=O)c12,,c1ccncc1,,O,,val
US20140243302A1,O=C1COc2cnc(Br)cc2N1.OB(O)C=Cc1ccccc1>>O=C1COc2cnc(/C=C/c3ccccc3)cc2N1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20060041123A1,COc1ccc2ncc(Cl)c(C(CO)CN3CCC(NC(=O)OC(C)(C)C)CC3)c2n1>>COc1ccc2ncc(Cl)c(C(CO)CN3CCC(N)CC3)c2n1,,C1COCCO1,ClCCl,Cl,,val
US20010020087A1,CCOC(=O)/C=C/CBr.CCc1ccc(C2=NC(C)(C(C)C)C(=O)N2)nc1>>CCOC(=O)/C=C/CN1C(=O)C(C)(C(C)C)N=C1c1ccc(CC)cn1,,C1CCOC1,,[H-].[Na+],,val
US04637902,NO.O=C(Oc1ccccc1)c1cc(Br)ccc1O>>O=C(NO)c1cc(Br)ccc1O,,CO,,Cl,[K+].[OH-],val
US20160152543A1,COC(=O)C(OC(C)(C)C)c1c(C)ccc(OCc2ccc(OC)cc2)c1-c1ccc(F)cc1>>COC(=O)C(OC(C)(C)C)c1c(C)ccc(O)c1-c1ccc(F)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US20080085890A1,CN1CCC(N(C)c2ccc([N+](=O)[O-])cc2)C1>>CN1CCC(N(C)c2ccc(N)cc2)C1,[Pd],CCO,,,,val
US20030139435A1,CNCC(C)(C)C.CONC(=O)c1ccc(C)c(Nc2nc(SC)nc(Cl)c2C#N)c1>>CONC(=O)c1ccc(C)c(Nc2nc(SC)nc(N(C)CC(C)(C)C)c2C#N)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US04711895,CC(C)(C)[Si](C)(C)OC1CC(=O)C=C1Cl.CCCCCCCC[Mg]Br>>CCCCCCCCC1(O)C=C(Cl)C(O)C1,,CCOCC,,C1CCOC1,O,val
US05576322,CS(=O)(=O)Cl.Nc1cc(CNc2ncnc3ccc(Cl)cc23)ccc1Cl>>CS(=O)(=O)Nc1cc(CNc2ncnc3ccc(Cl)cc23)ccc1Cl,,O,,c1ccncc1,,val
US20110301145A1,CN.O=[N+]([O-])c1cc(CBr)n(CCBr)n1>>CN1CCn2nc([N+](=O)[O-])cc2C1,,C1CCOC1,,,,val
US20130172552A1,CCn1c2ccccc2c2cc(N)ccc21.Clc1ccnc(Cl)n1>>CCn1c2ccccc2c2cc(Nc3ccnc(Cl)n3)ccc21,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US04058611,NO.S=c1cc(-c2cnccn2)ss1>>ON=c1cc(-c2cnccn2)ss1,,CO,O,Cl,CC(=O)[O-].[Na+],val
US20070219203A1,C[C@@H]1CN(Cc2nc(O)c3ccc(-c4ncccc4Cl)cc3n2)C[C@@H](C)O1.O=P(Cl)(Cl)Cl>>C[C@@H]1CN(Cc2nc(Cl)c3ccc(-c4ncccc4Cl)cc3n2)C[C@@H](C)O1,,ClC(Cl)Cl,,Cc1cccc(C)n1,,val
US20160159755A1,CCc1cccc(O)c1.O=C1CCC(=O)N1Br>>CCc1cc(O)ccc1Br,,ClC(Cl)Cl,,,,val
US06511974B1,COC(=O)c1ccc(NN)cc1OC.COC(CC(C)=O)OC>>COC(=O)c1ccc(-n2ccc(C)n2)cc1OC,Cl,CO,O,,,val
US06689780B1,CC(C)(C)c1ccc(C(=O)Cl)cc1.Nc1nccnc1C(=O)Nc1ccc(Cl)cn1>>CC(C)(C)c1ccc(C(=O)Nc2nccnc2C(=O)Nc2ccc(Cl)cn2)cc1,,c1ccncc1,,,,val
US03953506,NCCO.O=C=NC1CCCc2ccccc21>>O=C(NCCO)NC1CCCc2ccccc21,,CCOCC,,,,val
US20100076229A1,CC(C)(C)C=Cc1ccccc1[N+](=O)[O-]>>CC(C)(C)CCc1ccccc1N,[Pd],CO,,[H][H],,val
US20090215759A1,C1COCCN1.O=C(O)c1cc(-c2ccc(C(F)(F)F)cc2)nc(Cl)n1>>O=C(c1cc(-c2ccc(C(F)(F)F)cc2)nc(Cl)n1)N1CCOCC1,,CN(C)C=O,ClCCl,O=C(Cl)C(=O)Cl,O=C([O-])O.[Na+],val
US20120028961A1,COC(=O)c1ccc2nnsc2c1.c1csnn1>>NCc1ccc2nnsc2c1,,CO,,[BH4-].[Na+],,val
US20060074075A1,CCBr.O=[N+]([O-])c1ccc2cc[nH]c2c1>>CCc1c[nH]c2cc(N)ccc12,,CC#N,,,,val
US20030013124A1,Cc1ccc(S(N)(=O)=O)cc1.O=C1CCC(=O)O1>>Cc1ccc(S(N)(=O)=O)cc1C(=O)CCC(=O)O,CN(C)c1ccncc1,CC#N,,CCN(C(C)C)C(C)C,,val
US20150191461A1,CC(C)(C)OC(=O)C1CCC(OS(C)(=O)=O)CC1.CC1(C)OB(c2cn[nH]c2)OC1(C)C>>CC(C)(C)OC(=O)C1CCC(n2cc(B3OC(C)(C)C(C)(C)O3)cn2)CC1,,CCOCC,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US06472386B1,COc1cc(-c2nc(CO)cs2)cc(OC)c1OC.O=S(Cl)Cl>>COc1cc(-c2nc(CCl)cs2)cc(OC)c1OC,,ClCCl,,,,val
US20100004331A1,CCOC(=O)Cc1ccc(OC)c(Oc2ccc([N+](=O)[O-])cc2CBr)c1.FC(F)(F)CS>>CCOC(=O)Cc1ccc(OC)c(Oc2ccc([N+](=O)[O-])cc2CSCC(F)(F)F)c1,,C1COCCO1,,[H-].[Na+],,val
US20160194332A1,CC(=O)OC1C[C@H](NC(=O)OC(C)(C)C)Cn2c1c(-c1cnc3ccccc3c1)c1c(N)ncnc12>>CC(C)(C)OC(=O)N[C@H]1CC(O)c2c(-c3cnc4ccccc4c3)c3c(N)ncnc3n2C1,,CO,,O,[Na+].[OH-],val
US20150361123A1,CI.COc1ccc2[nH]c(C)cc2c1F>>COc1ccc2c(cc(C)n2C)c1F,,C1CCOC1,,[H-].[Na+],,val
US20100029621A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(N)c(Cl)c2)CC1>>Nc1ccc(C(=O)N2CCNCC2)cc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120309739A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3oc4ncc(Cl)nc4c3-c3ccccc3)cc2)CCC1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>Cn1cc(-c2cnc3oc(-c4ccc(C5(NC(=O)OC(C)(C)C)CCC5)cc4)c(-c4ccccc4)c3n2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US04670447,CN1CCC(c2n[nH]c3ccccc23)CC1.O=C(Cl)c1ccc(Cl)c(Cl)c1>>CN1CCC(c2nn(C(=O)c3ccc(Cl)c(Cl)c3)c3ccccc23)CC1,,CCOCC,,,,val
US20140031364A1,COC(=O)c1c(-c2cccc(OC(F)(F)F)c2)noc1N>>Nc1onc(-c2cccc(OC(F)(F)F)c2)c1C(=O)O,,CO,,[Na+].[OH-],,val
US20070021405A1,CC(C)(C)OC(=O)N1CCC(n2cnc(-c3ccccc3)c2)CC1>>c1ccc(-c2cn(C3CCNCC3)cn2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120088746A1,CS(=O)(=O)Cl.Cc1cc(Cl)ncc1N>>Cc1cc(Cl)ncc1NS(C)(=O)=O,,CCOC(C)=O,c1ccncc1,,,val
US05547975,CC(C)c1ccccc1SCCC(=O)O>>CC(C)c1cccc2c1SCCC2=O,,O=C(O)C(F)(F)F,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20100029753A1,CC(C)(C)c1cccc(Br)c1.O=S(=O)(O)Cl>>CC(C)(C)c1ccc(S(=O)(=O)O)c(Br)c1,,ClCCl,,CO,,val
US20110263850A1,CCN(CC(=O)O)Cc1c(N)ccc(Cl)c1Cl.N#CBr.O=C1CN2Cc3c(ccc(Cl)c3Cl)N=C2N1>>N=c1ncc2ccccc2[nH]1,,Cc1ccccc1,,Cl,O,val
US20160137704A1,COC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COC(=O)CCCC[C@@H]1SC[C@@H]2NC(=S)N[C@@H]21,,Cc1ccccc1,,,,val
US20160122300A1,COc1cc(N)c(Cl)cc1C(=O)O.OCC1CCN(CC2CCCCC2)CC1>>COc1cc(N)c(Cl)cc1C(=O)OCC1CCN(CC2CCCCC2)CC1,,C1CCOC1,CCOC(C)=O,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20080021011A1,CCC(=O)Cl.Fc1ccc(Cc2cc(-c3ccncc3)nn2C2CNC2)cc1>>CCC(=O)N1CC(n2nc(-c3ccncc3)cc2Cc2ccc(F)cc2)C1,,ClCCl,,CCN(CC)CC,,val
US20110098429A1,O=C(OO)c1cccc(Cl)c1.O=Cc1cccc(-c2ccccc2)c1OCc1ccccc1>>Oc1cccc(-c2ccccc2)c1OCc1ccccc1,,ClCCl,,,,val
US20090082434A1,Cc1ccc(S(=O)(=O)OCC2Cc3cccc(Br)c3O2)cc1.Cc1ccccc1B(O)O>>Cc1ccc(S(=O)(=O)OCC2Cc3cccc(-c4ccccc4C)c3O2)cc1,Cc1ccccc1[P](c1ccccc1C)(c1ccccc1C)[Pd](Cl)(Cl)[P](c1ccccc1C)(c1ccccc1C)c1ccccc1C,,,O=C([O-])[O-].[K+].[K+],,val
US20080089932A1,O=C(O)CCCCC(=O)O>>O=C1CCCCC(=O)O1,,CC(=O)OC(C)=O,,,,val
US20160221945A1,COCCOc1cc(-c2ccc(C(F)(F)F)nc2)cc(C#N)n1.Cl>>COCCOc1cc(-c2ccc(C(F)(F)F)nc2)cc(CN)n1.Cl,[Pd],CO,,,,val
US04292317,CN1CCNCC1.O=C(O)c1cn(CCO)c2cc(Cl)c(F)cc2c1=O>>CN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3CCO)CC1,,c1ccncc1,,,,val
US20100249119A1,CN(c1ccc(F)c(NC(=O)C(F)(F)F)c1)c1ccc2nc(N)sc2n1.O=C(Cl)C1CC1>>CN(c1ccc(F)c(NC(=O)C(F)(F)F)c1)c1ccc2nc(NC(=O)C3CC3)sc2n1,,c1ccncc1,,,,val
US04670043,CC(=O)C1CCCCC1=O.CC(C)Oc1cc(NN)c(F)cc1Cl>>Cc1c2c(nn1-c1cc(OC(C)C)c(Cl)cc1F)CCCC2,,Cc1ccccc1C,,CC(=O)O,,val
US04929614,O=C(c1ccccc1F)c1cccc2c1NCC2.O=C1CCC(=O)N1Cl>>O=C(c1ccccc1F)c1cc(Cl)cc2c1NCC2,,ClCCl,,,,val
US20100190804A1,COc1ccc(Br)c(CN)c1.Clc1ncc(Cl)c(Cl)n1>>COc1ccc(Br)c(CNc2nc(Cl)ncc2Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130324531A1,CC1(C)OCC(CO)O1.COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F>>COc1cc(C(=O)OCC2COC(C)(C)O2)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F,,C1CCOC1,,[H-].[Na+],,val
US20150284358A1,CCOC(=O)c1c(Cl)nc(-c2cccnc2)n1Cc1cc(Cl)ccc1Cl>>O=C(O)c1c(Cl)nc(-c2cccnc2)n1Cc1cc(Cl)ccc1Cl,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20080027048A1,CC(=O)OC(C)=O.COC(=O)c1ccc(-c2ccc(O)cc2)s1>>COC(=O)c1ccc(-c2ccc(OC(C)=O)cc2)s1,,C1CCOC1,,[H-].[Na+],,val
US20080153812A1,C1CCN2CCNCC2C1.COc1cc(CCc2cc(NC(=O)c3cnc(Cl)cn3)[nH]n2)cc(OC)c1>>COc1cc(CCc2cc(NC(=O)c3cnc(N4CCN5CCCCC5C4)cn3)[nH]n2)cc(OC)c1,,CS(C)=O,,,,val
US20110071115A1,CCN(CC)Cc1cccc(N)c1.O=Cc1cnn2ccc(Cl)nc12>>CCN(CC)Cc1cccc(Nc2ccn3ncc(C=O)c3n2)c1,,C1COCCO1,,ClCCl,,val
US06432993B1,CN(C(=O)OC(C)(C)C)c1cc(Cl)ccc1[N+](=O)[O-].O=C(c1ccccc1)c1ccc(O)cc1O>>CN(C(=O)OC(C)(C)C)c1cc(Oc2ccc(C(=O)c3ccccc3)c(O)c2)ccc1[N+](=O)[O-],,CN(C)C=O,,[H-].[Na+],,val
US20130338367A1,C=CC(=O)Cl.CCNc1cn(-c2cccnc2)nc1Cl>>C=CC(=O)N(CC)c1cn(-c2cccnc2)nc1Cl,,ClCCl,,O=C([O-])O.[Na+],,val
US20100234363A1,COCOc1ccc([N+](=O)[O-])cc1>>COCOc1ccc(N)cc1,O=[Pt]=O,CO,,,,val
US20030060460A1,CNC.COCOC(=O)CN(c1ccc(C(F)(F)F)cc1OCc1ccc(C(=O)OCOC)cc1)S(=O)(=O)c1ccccc1>>CN(C)C(=O)CN(c1ccc(C(F)(F)F)cc1OCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccccc1,,C1CCOC1,,,,val
US20060094767A1,CC(C)(C)OC(=O)N1CCN(c2cccc(OC3CCCCO3)c2)CC1>>CC(C)(C)OC(=O)N1CCN(c2cccc(O)c2)CC1,,CCO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20160207905A1,CI.O=[N+]([O-])c1ccc(F)c(Nc2nc(Cl)ncc2Cl)c1>>CN(c1cc([N+](=O)[O-])ccc1F)c1nc(Cl)ncc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05635477,CC(C)(C)OC(=O)ON=C(C#N)c1ccccc1.NCc1cccc2ccc(C(=O)O)cc12>>CC(C)(C)OC(=O)NCc1cccc2ccc(C(=O)O)cc12,,C1CCOC1,,CCN(CC)CC,,val
US03969506,CSC1=NCCN1.O=c1oc(=O)n(-c2ccc(F)cc2)c2ccccc12>>O=C1c2ccccc2N(c2ccc(F)cc2)C2=NCCN12,,C1COCCO1,,[Na+].[OH-],,val
US20140066424A1,CCOC(=O)c1n[nH]c(C)n1.N>>Cc1nc(C(N)=O)n[nH]1,,CO,,,,val
US20130210787A1,C=C(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(OS(=O)(=O)C(F)(F)F)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.COC(=O)C1CC2(C=C(B3OC(C)(C)C(C)(C)O3)C2)C1>>C=C(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC7(C6)CC(C(=O)OC)C7)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20110015178A1,CS(=O)(=O)Cl.O=C(c1csc(-c2cn[nH]c2)c1)N1CCCNCC1>>CS(=O)(=O)N1CCCN(C(=O)c2csc(-c3cn[nH]c3)c2)CC1,,ClCCl,,CCN(CC)CC,,val
US20100040753A1,CO[Na].O=C(CO)c1ccccc1.O=Cc1ccc(Cl)nc1>>O=C(C=Cc1ccccc1)c1ccccc1,,C1CCOC1,,,,val
US04975444,CCOC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)C1(CC(CNC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NS(C)(=O)=O)C(=O)OC(C)(C)C)CCCC1>>CC(C)(C)OC(=O)NCCCC[C@H](NS(C)(=O)=O)C(=O)NCC(CC1(C(=O)N[C@@H](Cc2ccc(OC(C)(C)C)cc2)C(=O)O)CCCC1)C(=O)OC(C)(C)C,,CC(C)=O,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US20120190701A1,CS(=O)(=O)Cl.OCc1ccnc2ccccc12>>CS(=O)(=O)OCc1ccnc2ccccc12,,ClCCl,,CCN(CC)CC,,val
US20090131502A1,O=C(OCc1c(F)cccc1C(F)(F)F)n1ccnc1.O=C(c1ccccc1)N1C[C@H](O)[C@H]2NCC[C@H]21>>O=C(c1ccccc1)N1C[C@H](O)[C@@H]2[C@H]1CCN2C(=O)OCc1c(F)cccc1C(F)(F)F,,ClCCl,,,,val
US20100298301A1,CC(=O)N1CCNCC1.CC1(C)OB(c2ccc(Br)cc2)OC1(C)C.CN(C)C=O>>CC(=O)N1CCN(Cc2ccc(B(O)O)cc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110207728A1,COC(=O)c1cc(Br)cn1CC(=O)c1cnc(C)cn1.NCCN>>Cc1cnc(C23Cn4cc(Br)cc4C(=O)N2CCN3)cn1,,C1COCCO1,,,,val
US06323235B1,COC(=O)C1(C)Oc2c(OC)cccc2C1=O>>COc1cccc2c1OC(C)C2=O,,C1COCCO1,O,O=S(=O)(O)O,,val
US20040097526A1,Cc1cc(F)c2c(c1)C(=O)C(=O)N2>>Cc1cc(F)c2[nH]ccc2c1,,O,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20150005279A1,COC(=O)c1ccc(Br)c2c(C=O)c[nH]c12.COc1ccc(CN)cc1>>COC(=O)c1ccc(Br)c2c(CNCc3ccc(OC)cc3)c[nH]c12,,ClCCCl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100022505A1,COc1cc2ncn(Cc3ccccc3)c(=O)c2cc1OC1CCC2(CC1)OCCO2>>COc1cc2nc[nH]c(=O)c2cc1OC1CCC2(CC1)OCCO2,[Pd],CC(=O)O,,[H][H],,val
US06462036B1,COC(=O)c1ccc(-c2n[nH]c3c2Cc2ccccc2-3)cc1.NCCN1CCOCC1>>O.O=C(NCCN1CCOCC1)c1ccc(-c2n[nH]c3c2Cc2ccccc2-3)cc1,,ClCCl,,,,val
US20080280855A1,COC1(c2ccccc2C)CCc2c(CO)cc3c(nc(C)n3C)c2O1.O=S(Cl)Cl>>COC1(c2ccccc2C)CCc2c(CCl)cc3c(nc(C)n3C)c2O1,,ClCCl,,O=C([O-])O.[Na+],,val
US20130281452A1,CCS(=O)c1cc(N2CCOCC2)cc(C)c1C#N.O>>CCS(=O)c1cc(N2CCOCC2)cc(C)c1C(N)=O,,CCO,O,[Na+].[OH-],,val
US20120059028A1,COC(=O)C(OC(C)(C)C)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCCC3>>Cc1ccc(-c2c(C(OC(C)(C)C)C(=O)O)c(C)nc3sc4c(c23)CCCC4)cc1,,CO,,[Na+].[OH-],,val
US20080139484A1,COc1ccc(C(C)(C)O)cc1.Clc1cccc2[nH]ccc12>>COc1ccc(C(C)(C)c2c[nH]c3cccc(Cl)c23)cc1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20080139600A1,CC(C)OB(OC(C)C)OC(C)C.CN(C)Cc1cc(Br)cs1>>CC(C)OB(OC(C)C)c1csc(CN(C)C)c1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20080064715A1,Cl.Cl.N=C(N)NN.O=C(c1ccccc1)c1cc2cc(Cl)ncc2[nH]1>>Cl.Cl.N=C(N)NN=C(c1ccccc1)c1cc2cc(Cl)ncc2[nH]1,,CCO,,,,val
US20020173518A1,CC(C)(C)OC(=O)n1ncc2ccc(NC(=O)c3ccccc3N)cc21.CC(C)(C)c1ccc2c(c1)C(=O)OC2=O>>CC(C)(C)c1ccc2c(c1)C(=O)N(c1ccccc1C(=O)Nc1ccc3cn[nH]c3c1)C2=O,,C1CCOC1,CCOCC,,,val
US20080004269A1,CCCC1C(Cl)=NC=CN1O.CCOC(=O)Cc1ccnn1-c1ncccc1Br>>CCCC1C(C(C(=O)OCC)c2ccnn2-c2ncccc2Br)=NC=CN1O,,CS(C)=O,O,CCOC(C)=O,[H-].[Na+],val
US20160137652A1,CCOC(=O)C(CC)C1CCN(C(=O)OC(C)(C)C)CC1>>CCOC(=O)C(CC)C1CCNCC1,,C1COCCO1,,Cl,,val
US20120238599A1,C=COCCONC(=O)c1c(Nc2ccc(I)cc2F)n(C)c(=O)c2ccsc12>>Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOCCO)c2sccc2c1=O,,CO,,Cl,,val
US20090221663A1,CCCSc1c(C(=O)NC2CCCCC2)cnn1Cc1ccc(C(=O)OC)cc1>>CCCSc1c(C(=O)NC2CCCCC2)cnn1Cc1ccc(C(=O)O)cc1,,CO,,O,[Li+].[OH-],val
US20040082571A1,Fc1ccc(N2CCNCC2)cc1.O=C(Cl)CCl>>O=C(CCl)N1CCN(c2ccc(F)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20010021718A1,CCOC(=O)COCc1noc([C@H](CCCC2CCCCC2)CC(=O)NO)n1>>O=C(O)COCc1noc([C@H](CCCC2CCCCC2)CC(=O)NO)n1,,C1COCCO1,O,[Li+].[OH-],,val
US20040142999A1,CCC(NC(=O)C(O)CC1CCCCC1)C(O)c1nc2ncccc2o1>>CCC(NC(=O)C(O)CC1CCCCC1)C(=O)c1nc2ncccc2o1,O=[Mn]=O,ClCCl,,,,val
US20100003710A1,NC[c-]1cccc1.O=C(O)CCCCCCCCCCS.[Fe+2].c1cc[cH-]c1>>O=C(CCCCCCCCCCS)NC[c-]1cccc1.[Fe+2].c1cc[cH-]c1,,CC(C)=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US05075437,CCOC(=O)C(=O)N1C(=O)[C@H]([C@@H](C)O[Si](C)(C)C(C)(C)C)[C@H]1[C@@H](C)C(=O)OC>>COC(=O)[C@H](C)[C@H]1NC(=O)[C@@H]1[C@@H](C)O[Si](C)(C)C(C)(C)C,,CO,,CCN(CC)CC,,val
US20110319380A1,CC1CCNC(=O)CC1.COS(=O)(=O)OC>>COC1=NCCC(C)CC1,,CCOCC,,[K+].[OH-],,val
US20020091111A1,CCCCCCCC(=O)N[C@H]1CC[C@]2(C)[C@H]3C[C@H](O)[C@]4(C)[C@@H]([C@H](C)CCC(=O)OC)CC[C@H]4[C@@H]3[C@H](O)C[C@@H]2C1>>CCCCCCCC(=O)N[C@H]1CC[C@]2(C)[C@H]3C[C@H](O)[C@]4(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@H]4[C@@H]3[C@H](O)C[C@@H]2C1,,CO,,[Na+].[OH-],,val
US20110294807A1,CCC(C)c1ccc(-n2c(-c3cc(C)c(OCCO[Si](C)(C)C(C)(C)C)c(C)c3)nc3ccccc3c2=O)cc1>>CCC(C)c1ccc(-n2c(-c3cc(C)c(OCCO)c(C)c3)nc3ccccc3c2=O)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090264418A1,CS(=O)(=O)OCC(F)(F)F.O=C(c1ccc2[nH]c(C(=O)N3CCC(F)(F)CC3)cc2c1)N1CCN(C2CCC2)CC1>>O=C(c1ccc2c(c1)cc(C(=O)N1CCC(F)(F)CC1)n2CC(F)(F)F)N1CCN(C2CCC2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20130072467A1,NCC1(CO)CCC1.O=C1NC(=S)CS1>>O=C1N=C(NCC2(CO)CCC2)CS1,,CCO,,,,val
US20150257385A1,CC(C)(C)OC(=O)NCCc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1.Cl>>Cl.NCCc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1,,CCOC(C)=O,,,,val
US20120053053A1,COC(=O)c1nc(-c2ccc(C(F)(F)F)cc2)nc(N)c1C(C)=O>>CC(O)c1c(N)nc(-c2ccc(C(F)(F)F)cc2)nc1CO,,CO,,Cl,[BH4-].[Na+],val
US20100286148A1,CI.N#Cc1cc(C(O)C(F)(F)F)ccn1>>COC(c1ccnc(C#N)c1)C(F)(F)F,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20060116515A1,CC(C)(C)OC(=O)CBr.CCOC(=O)Cc1nc(-n2ccnc2)ns1>>CCOC(=O)C(CC(=O)O)c1nc(-n2ccnc2)ns1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20160039841A1,Cc1c(Br)sc2c1c(=O)n(CCCO)c(=O)n2C.OB(O)c1ccc(Cl)c(Cl)c1>>Cc1c(-c2ccc(Cl)c(Cl)c2)sc2c1c(=O)n(CCCO)c(=O)n2C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20160009683A1,CCOC(=O)C(F)(F)Br.Ic1cccc(N2CCCCC2)c1>>CCOC(=O)C(F)(F)c1cccc(N2CCCCC2)c1,[Cu],CS(C)=O,O,,,val
US06303628B1,COC(=O)Cc1c(C(=O)c2cc3c(cn2)CCCC3)[nH]c2cc(Cl)ccc12>>O=C(O)Cc1c(C(=O)c2cc3c(cn2)CCCC3)[nH]c2cc(Cl)ccc12,,CO,,C1CCOC1,[Na+].[OH-],val
US20060264460A1,CCO.Cc1cc([N+](=O)[O-])cc2c(Nc3cccc(Br)c3)c(C#N)cnc12.Cl[Sn]Cl.O.O=C([O-])O.[Na+]>>CCOC(C)=O.O.[Cl-].[Na+],,O,,,,val
US20110190280A1,COC(=O)c1ccc2c(c1)OCO2.Cc1ccnc(Cl)n1>>O=C(Cc1ccnc(Cl)n1)c1ccc2c(c1)OCO2,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20080153861A1,COc1cc(Br)c2[nH]ccc2c1.O=C=O>>COc1cc(C(=O)O)c2[nH]ccc2c1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20110207783A1,COCCCc1ccc(Cl)c(CN(C(=O)CC#N)C2CC2)c1.O=Cc1cccc2[nH]ccc12>>COCCCc1ccc(Cl)c(CN(C(=O)/C(C#N)=C/c2cccc3[nH]ccc23)C2CC2)c1,C1CCNCC1,Cc1ccccc1,,,,val
US20070155726A1,O=Cc1ccc(F)cc1.Oc1ccc(Br)cc1>>O=Cc1ccc(Oc2ccc(Br)cc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070293515A1,CC(C)(C)OC(=O)N[C@H]1CC[C@H](c2nnc(Cc3ccccc3)o2)C1>>N[C@H]1CC[C@H](c2nnc(Cc3ccccc3)o2)C1,,CCOC(C)=O,,Cl,,val
US20050119481A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@@H](NCc1cccc([N+](=O)[O-])c1)[C@H](F)c1ccccc1>>C[C@H]([C@H](F)c1ccccc1)N(Cc1cccc([N+](=O)[O-])c1)C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20070032478A1,CC(=O)Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3=CO)c1.COc1ccc(N)cc1O>>COc1ccc(NC=C2C(=O)Nc3cc(C(=O)c4cccc(NC(C)=O)c4)ccc32)cc1O,,C1CCOC1,,,,val
US20080255124A1,N#Cc1ccc(N(CCO)CC(F)(F)F)cc1C(F)(F)F.Oc1ccc(C(F)(F)F)cn1>>N#Cc1ccc(N(CCOc2ccc(C(F)(F)F)cn2)CC(F)(F)F)cc1C(F)(F)F,,COCCOC,,,,val
US20070149614A1,CCO[C@@H](Cc1ccc(OCCCCc2ccc([N+](=O)[O-])cc2)cc1)C(=O)O>>CCO[C@@H](Cc1ccc(OCCCCc2ccc(N)cc2)cc1)C(=O)O,[Pd],CCOC(C)=O,,,,val
US20030073837A1,Cc1cc(C(=O)O)[nH]c1C=O.O=C1Cc2ccccc2N1>>Cc1cc(C(=O)O)[nH]c1C=C1C(=O)Nc2ccccc21,C1CCNCC1,CCO,,,,val
US20040110804A1,NCc1ccc(F)cc1.O=C(Cl)c1ccc(F)cc1>>O=C(NCc1ccc(F)cc1)c1ccc(F)cc1,,ClCCl,,[Na+].[OH-],,val
US20070225267A1,CC(=O)OC(C)=O.CCCOc1cc(F)cc(C[C@H](N)[C@H](O)[C@H]2CO[C@@H](OCC(C)(C)CF)[C@H](C)N2C(=O)OC(C)(C)C)c1>>CCCOc1cc(F)cc(C[C@H](NC(C)=O)[C@H](O)[C@H]2CO[C@@H](OCC(C)(C)CF)[C@H](C)N2C(=O)OC(C)(C)C)c1,,ClCCl,,CCN(CC)CC,,val
US20110065708A1,CC(=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1.CON>>CO/N=C(\C)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1,,CO,,CCN(CC)CC,Cl,val
US20090186870A1,CCOc1cc(Cl)c(C(=O)OC)cc1[N+](=O)[O-]>>CCOc1cc(Cl)c(C(=O)OC)cc1N,[Pt],C1CCOC1,CO,,,val
US20130261077A1,CC(=O)OC[C@H]1O[C@H](c2ccc(O)cc2)[C@@H](O)[C@@H](O)[C@@H]1OC(C)=O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(=O)OC[C@H]1O[C@H](c2ccc(OS(=O)(=O)C(F)(F)F)cc2)[C@@H](O)[C@@H](O)[C@@H]1OC(C)=O,,ClCCl,,CCN(CC)CC,,val
US05356881,C[C@H]1O[C@@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]5(C)[C@@H](C7=CC(=O)OC7)CC[C@]65O)C4)O[C@@H]3C)O[C@@H]2C)C[C@H](O)[C@@H]1O.O>>C[C@]12CC[C@H](O)C[C@H]1CC[C@@H]1[C@@H]2C[C@@H](O)[C@]2(C)[C@@H](C3=CC(=O)OC3)CC[C@]12O.O,,CCO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US04728651,COc1ccccc1-c1noc2ccsc12>>Oc1ccccc1-c1noc2ccsc12,,ClCCl,,BrB(Br)Br,,val
US20090093465A1,ClCCl.O=C(O)c1ccsc1Br>>COC(=O)c1ccsc1Br,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20140179680A1,CC([C@@H]1CC[C@@H](C)CC1)n1cnc2cc(C#N)nc(-c3cncc(Cl)c3)c21.O=C1CCC(=O)N1Br>>CC([C@@H]1CC[C@@H](C)CC1)n1c(Br)nc2cc(C#N)nc(-c3cncc(Cl)c3)c21,,ClC(Cl)Cl,ClCCl,,,val
US20090286060A1,COC(=O)Cl.O=C1c2ccccc2C(=O)N1O>>COC(=O)ON1C(=O)c2ccccc2C1=O,,C1CCOC1,,CCN(CC)CC,,val
US04472305,CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(N)=O>>CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1)C(N)=O,,CC(=O)O,,Cl,,val
US20100210851A1,CS(=O)(=O)c1ccc([C@H]2OC(=O)N(C(=O)C(Cl)Cl)[C@@H]2CF)cc1>>CS(=O)(=O)c1ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc1,,C1CCOC1,,O,[Li+].[OH-],val
US20120258950A1,C=CCc1c(Cl)ncnc1Cl.O=[O+][O-]>>O=CCc1c(Cl)ncnc1Cl,,ClCCl,,,,val
US20120329791A1,CN(C)C(=O)C1CN(Cc2ccccc2)CCO1>>CN(C)C(=O)C1CNCCO1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20140179672A1,Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NCC3CN(Cc4ccccc4)CCO3)n2c1>>Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NCC3CNCCO3)n2c1,[Pd],CCO,,,,val
US04618619,ClCC1(COc2ccc(Cl)cc2Cl)CO1.Clc1ccc(OCC2(COc3ccc(Cl)cc3Cl)CO2)c(Cl)c1.c1nc[nH]n1>>OC(COc1ccc(Cl)cc1Cl)(COc1ccc(Cl)cc1Cl)Cn1cncn1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130331349A1,Cc1ccccc1C=O.NO>>Cc1ccccc1/C=N/O,,CCO,O,Cl,[Na+].[OH-],val
US20050119274A1,COC(=O)C(=O)c1c[nH]c2c(C)cccc12.NC(=O)Cc1nc(N2CCNC3(CC3)C2)cc2ccccc12>>Cc1cccc2c(C3=C(c4nc(N5CCNC6(CC6)C5)cc5ccccc45)C(=O)NC3=O)c[nH]c12,,O,,C1CCOC1,,val
US20130281433A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccc(Br)cc3)sc2c1-c1ccc(Cl)cc1.Cc1c(B(O)O)cnn1C>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccc(-c4cnn(C)c4C)cc3)sc2c1-c1ccc(Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20100048551A1,BrBr.Oc1nccc2sc3ccc(Cl)cc3c12>>Oc1ncc(Br)c2sc3ccc(Cl)cc3c12,,CC(=O)O,,O,,val
US20140179666A1,COC[C@H]1CN(C(=O)OC(C)(C)C)[C@H](C)CN1.O=C(CBr)OCc1ccccc1>>COC[C@H]1CN(C(=O)OC(C)(C)C)[C@H](C)CN1CC(=O)OCc1ccccc1,,ClC(Cl)Cl,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20100130506A1,N.O=C1CCN(Cc2ccccc2)CC1.[C-]#N>>NCC1(N)CCN(Cc2ccccc2)CC1,,O,,[Cl-].[NH4+],,val
US20050107399A1,CC(C)(C)c1ccc(O)cc1.ClCCl>>CC(C)(C)c1ccc(O)c(Cl)c1,,CO,,,,val
US20130161599A1,CC(=O)Cl.OCc1ccsc1>>CC(=O)OCc1ccsc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20040191811A1,CC(=O)N[C@H]1[C@@H](OP(=O)(O)OP(=O)(O)OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](O)[C@@H]2O)O[C@H](CO)[C@@H](O)[C@@H]1O>>CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O,,Cl,,,,val
US05554620,C#C[Mg]Br.O=Cc1ccoc1>>C#CC(O)c1ccoc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20050124604A1,CCOC(=O)c1c(O)c2cccnc2n(Cc2ccc(OC)cc2)c1=O.NC1CCCCC1>>COc1ccc(Cn2c(=O)c(C(=O)NC3CCCCC3)c(O)c3cccnc32)cc1,,Cc1ccccc1C,,,,val
US05219871,CNCCCC(C(N)=O)(c1ccccc1)c1ccccc1.COc1ccc(CCBr)cc1>>COc1ccc(CCN(C)CCCC(C(N)=O)(c2ccccc2)c2ccccc2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120196864A1,CCN(CC)CCN.COc1cc(C=O)ccc1Oc1ccc(C#N)cc1Cl.O=C1NC(=S)CS1>>CCN(CC)CCNC1=NC(=O)S/C1=C\c1ccc(Oc2ccc(C#N)cc2Cl)c(OC)c1,,CCO,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20140179689A1,COc1cccc(CC(=O)Nc2cccc3[nH]ccc23)c1.Nc1nccc(Cl)n1>>COc1cccc(CC(=O)Nc2cccc3c2ccn3-c2ccnc(N)n2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070135477A1,COC(=O)c1cccc([N+](=O)[O-])c1NC(C)=O>>COC(=O)c1cccc([N+](=O)[O-])c1N,,CO,,Cl,C[O-].[Na+],val
US20150284321A1,Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ccccc1NC(=O)Nc1ccccc1>>Cc1ccc(S(=O)(=O)Nc2ccccc2NC(=O)Nc2ccccc2)cc1,,CCOC(C)=O,,c1ccncc1,,val
US20140323664A1,CC(=O)c1ccc(O)cc1.OCCCBr>>CC(=O)c1ccc(OCCCO)cc1,C1COCCOCCOCCOCCOCCO1,CC(C)=O,,N#N,O=C([O-])[O-].[K+].[K+],val
US06967198B2,CC(C)(C)OC(=O)N1CC=C(c2[nH]c3cc(N)cc4c3c2C=NNC4=O)CC1>>CC(C)(C)OC(=O)N1CCC(c2[nH]c3cc(N)cc4c3c2C=NNC4=O)CC1,[Pd],CO,,,,val
US20130261101A1,Cc1c(Cl)cc(C(C)Cl)c2c1CN(C(=O)OC(C)(C)C)CCO2.Cc1n[nH]c2ncnc(N)c12>>Cc1c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc32)c2c1CN(C(=O)OC(C)(C)C)CCO2,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150252044A1,COCCN.O=C(O)c1ccc2cnccc2n1>>COCCNC(=O)c1ccc2cnccc2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090042892A1,COC(=O)c1cc2c(cc1-c1cc(C(C)C)c(F)cc1OC)CC=C2C>>COC(=O)c1cc2c(cc1-c1cc(C(C)C)c(F)cc1OC)CCC2C,[Pd],CCO,,,,val
US04929613,O=C1CCC(c2cc(F)c(Br)cc2F)C1.OCCO>>Fc1cc(C2CCC3(C2)OCCO3)c(F)cc1Br,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,,,val
US20110190294A1,N#Cc1c(-c2ccccc2)n(-c2ccc(O)cc2)c2ccccc12.OO>>NC(=O)c1c(-c2ccccc2)n(-c2ccc(O)cc2)c2ccccc12,,CCOC(C)=O,CO,Cl,[K+].[OH-],val
US20150126490A1,Cn1cc(-c2cnc(N)cc2F)cn1.O=C1CCC(=O)N1Br>>Cn1cc(-c2cnc(N)c(Br)c2F)cn1,,CC#N,,,,val
US20020128301A1,CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O.COc1ccc(COC(=O)c2ccc(O)cc2)cc1>>COc1ccc(COC(=O)c2ccc(OC(=O)[C@@H](NC(=O)OCc3ccccc3)C(C)C)cc2)cc1,,ClCCl,,CCO,,val
US20090163488A1,Cc1ccc(S(=O)(=O)Nc2ccc(Oc3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)cn2)cc1.NC(=O)CI>>Cc1ccc(S(=O)(=O)N=c2ccc(Oc3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)cn2CC(N)=O)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20020143020A1,CC[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)Cl.OCc1c(F)cc(OCC2CC2)cc1F>>CC[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)OCc1c(F)cc(OCC2CC2)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US20120316147A1,COC(=O)c1ccc(C(F)(F)F)c(Cl)n1.OCC1CC1>>O=C(O)c1ccc(C(F)(F)F)c(OCC2CC2)n1,,O,,Cl,[H-].[Na+],val
US20060009511A9,CN(C)C(N(C)C)N(C)C.Cc1cc(Oc2ccccc2)ccc1[N+](=O)[O-]>>c1ccc(Oc2ccc3[nH]ccc3c2)cc1,[Pd],CCOC(C)=O,Cc1ccccc1,[H][H],,val
US20060172019A1,CC12CCC(C1)C(C)(C)C2=O.NO>>CC1(C)C(=NO)[C@@]2(C)CCC1C2,,CO,O,Cl,CC(=O)[O-].[Na+],val
US20070004771A1,BrBr.O=C1C=CN=CC1[N+](=O)[O-]>>O=C1C([N+](=O)[O-])=CN=CC1Br,,O,,,,val
US20070225377A1,C#CC(C)(C)O.CCC(CC)(c1ccc(O[Si](C)(C)C(C)(C)C)c(C)c1)c1ccc(OS(=O)(=O)C(F)(F)F)c(C)c1>>CCC(CC)(c1ccc(C#CC(C)(C)O)c(C)c1)c1ccc(O[Si](C)(C)C(C)(C)C)c(C)c1,,CCOCC,,CN(C)C=O,,val
US20120190701A1,CS(=O)(=O)Cl.N#Cc1cccc(CO)c1>>CS(=O)(=O)OCc1cccc(C#N)c1,,ClCCl,,CCN(CC)CC,,val
US20120010182A1,Cn1nccc1-c1cc(-c2ccccc2)ccc1O.O=[N+]([O-])c1ccc(F)c(F)c1>>Cn1nccc1-c1cc(-c2ccccc2)ccc1Oc1ccc([N+](=O)[O-])cc1F,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20050049262A1,C[C@@H](CCCCn1c(=O)c2c(ncn2C)n(C)c1=O)OS(C)(=O)=O.[C-]#N>>C[C@@H](C#N)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O,,CS(C)=O,,O,,val
US20090298807A1,CCc1cc(C(=O)N2CCOC3(CCNCC3)C2)cs1.OCCc1cc(CBr)ccc1F>>CCc1cc(C(=O)N2CCOC3(CCN(Cc4ccc(F)c(CCO)c4)CC3)C2)cs1,,CC#N,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US06355638B1,CC(C)(C)C1C(=O)OC=C1O.NN>>CC(C)(C)C1=C(CO)N=NC1=O,,CCO,,O,,val
US20080103183A1,CC(=O)c1ccccc1.CN.[C-]#N>>CNC(C)(C#N)c1ccccc1,,CO,O,Cl,,val
US20130096118A1,CC(=O)c1ccc2c(c1)[nH]c1c(C(N)=O)ncc(-c3cccc(-n4cnc5ccccc5c4=O)c3C)c12.C[Mg]Br>>Cc1c(-c2cnc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1cnc2ccccc2c1=O,,C1CCOC1,,,,val
US20140296254A1,CC1(C=O)CCCO1.Cc1ccco1>>Cc1ccc(C(O)C2(C)CCCO2)o1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US05866589,CCOc1cccnc1N(C)C1CCN(Cc2ccccc2)CC1>>CCOc1cccnc1N(C)C1CCNCC1,[Pd],CO,,O=C[O-].[NH4+],,val
US05972979,COC(=O)C1=CCC2(CC1)OCCO2>>OCC1=CCC2(CC1)OCCO2,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20130072467A1,CC(C)C[C@H](N)C(=O)N(C)C.O=C1NC(=S)CS1>>CC(C)C[C@H](NC1=NC(=O)SC1)C(=O)N(C)C,,CCO,,CCN(CC)CC,Cl,val
US20070249589A1,CC1CN(Cc2ccccc2)CCC(=O)N1>>CC1CNCCC(=O)N1,[Pd],CCO,,,,val
US20120202785A1,CNc1c(N)ccc(F)c1-c1ccccn1.C[C@H](NC(=O)OC(C)(C)C)C(=O)O>>C[C@H](NC(=O)OC(C)(C)C)c1nc2ccc(F)c(-c3ccccn3)c2n1C,,ClCCl,,ClCCCl,On1nnc2cccnc21,val
US20110144105A1,COCc1cnc2c(c1)cc(C(O)CC1CCCC1)n2S(=O)(=O)c1ccccc1>>COCc1cnc2c(c1)cc(C(=O)CC1CCCC1)n2S(=O)(=O)c1ccccc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20030191099A1,CN(CCCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)CCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12>>CN(CCCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)CCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)C(=O)CC[C@H]3[C@H]12,,CCOC(C)=O,CS(C)=O,CCN(C(C)C)C(C)C,,val
US20020192594A1,C=C(C)C(=O)Cl.OCC(Br)(Br)Br>>C=C(C)C(=O)OCC(Br)(Br)Br,,CCOCC,,CCN(CC)CC,O,val
US20100076014A1,CC(C)c1cc2c(cnn2-c2ccc(F)cc2)cc1CO.COC(O[Si](C)(C)C)=C(C)C>>COC(=O)C(C)(C)Cc1cc2cnn(-c3ccc(F)cc3)c2cc1C(C)C,Cl[Ti](Cl)(Cl)Cl,,,ClCCl,,val
US20100305133A1,BrBr.COC(=O)c1c(OC)ccc([N+](=O)[O-])c1N>>COC(=O)c1c(N)c([N+](=O)[O-])cc(Br)c1OC,,ClCCl,,,,val
US20070254881A1,COCCN(CCOC)S(F)(F)F.COc1ccc(-n2nc(C(=O)N3CCOCC3)cc2-c2ccc(CO)cn2)nn1>>COc1ccc(-n2nc(C(=O)N3CCOCC3)cc2-c2ccc(CF)cn2)nn1,,ClCCl,,O=C([O-])O.[Na+],,val
US20130059834A1,COC[C@H](C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3ncn4cc(F)cc(F)c34)nc12>>COC[C@H](C)NC(=O)c1c[nH]c2ncc(-c3ncn4cc(F)cc(F)c34)nc12,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US20110250135A1,CC(C)(C)OC(=O)NCC(=O)N1CCN(c2ccc(OCc3ccccc3)cc2)CC1.Cl>>[Cl-].[NH3+]CC(=O)N1CCN(c2ccc(OCc3ccccc3)cc2)CC1,,CCOCC,,,,val
US20030225130A1,Brc1ccccc1.CN(C)CCOc1ccc(C(=O)C(CCOCc2ccccc2)c2ccc(Cl)cc2)cc1>>CN(C)CCOc1ccc(C(O)(c2ccccc2)C(CCOCc2ccccc2)c2ccc(Cl)cc2)cc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20140175384A1,COc1ccc(-c2ccc3ccc4cccc5ccc2c3c45)c(-c2ccccc2)c1>>Oc1ccc(-c2ccc3ccc4cccc5ccc2c3c45)c(-c2ccccc2)c1,,ClCCl,,BrB(Br)Br,,val
US20110269766A1,CCOC(OCC)OCC.Nc1cccc(C(=O)O)c1N>>CCOc1nc2c(C(=O)O)cccc2[nH]1,,O,,CC(=O)O,,val
US06410482B1,COC(=O)c1ccc(N=CN(C)C)cc1S(=O)(=O)NC(C)(C)C>>COC(=O)c1ccc(N=CN(C)C)cc1S(N)(=O)=O,,O=C(O)C(F)(F)F,,,,val
US20130045964A1,CC(C)[C@@H](N)C#N.O=C(O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1>>CC(C)[C@H](C#N)NC(=O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060264433A1,CC(C)(C)OC(=O)NC1CN(Cc2ccccc2)CC1c1ccc(F)cc1Cl.Clc1cc(Cl)ncn1>>CC(C)(C)OC(=O)NC1CN(c2cc(Cl)ncn2)CC1c1ccc(F)cc1Cl,,COCCOC,,,,val
US20040072827A1,Cc1sc(=Nc2ccccc2)n(CCCNC(=O)OC(C)(C)C)c1-c1ccccc1>>Cc1sc(=Nc2ccccc2)n(CCCN)c1-c1ccccc1,,C1COCCO1,,Cl,,val
US20110124665A1,Clc1ncnc2oc(-c3ccccc3)cc12.N[C@H]1CCC[C@H](O)C1>>O[C@H]1CCC[C@@H](Nc2ncnc3oc(-c4ccccc4)cc23)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20090324581A1,CC(C)(C)OC(=O)N1CCc2cc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)ccc21.Cl>>Cl.FC(F)(F)c1sc(COc2ccc3c(c2)CCN3)cc1-c1ccccc1,,C1COCCO1,,,,val
US04101536,CCCCCCCCCCCCCCC(CCCCCCCCCCCCCC)C(=O)O.O=S(Cl)Cl>>CCCCCCCCCCCCCCC(CCCCCCCCCCCCCC)C(=O)Cl,,c1ccccc1,,,,val
US06110962,CCOC(=O)CCl.O=Cc1cccnc1>>CCOC(=O)CCc1cccnc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20150141433A1,COC(=O)c1cnc(CNS(=O)(=O)c2ccc(F)c(Cl)c2)cn1>>O=C(O)c1cnc(CNS(=O)(=O)c2ccc(F)c(Cl)c2)cn1,,CO,,[K+].[OH-],,val
US05958927,COc1ccc2c(c1)C(=O)C(Br)C2.c1cc2c(c(N3CCNCC3)c1)OCCO2>>COc1ccc2c(c1)C(=O)C(N1CCN(c3cccc4c3OCCO4)CC1)C2,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150353539A1,CC(=O)c1cc2cc(C(=O)O)cnc2[nH]1.Cc1ccc([N+](=O)[O-])cc1N>>CC(=O)c1cc2cc(C(=O)Nc3cc([N+](=O)[O-])ccc3C)cnc2[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070088040A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.NCC1CCCN1>>c1ccc(C(NCC2CCCN2)(c2ccccc2)c2ccccc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20090131473A1,CC(C)S(=O)(=O)c1ccc([N+](=O)[O-])cc1C#N>>CC(C)S(=O)(=O)c1ccc(N)cc1C#N,[Pd],C1CCOC1,,,,val
US05756743,CN=C=O.Cn1c2c(c3cc(O)ccc31)CCC21CCN(Cc2ccccc2)CC1>>CNC(=O)Oc1ccc2c(c1)c1c(n2C)C2(CC1)CCN(Cc1ccccc1)CC2,Cl[Cu],ClCCl,,,,val
US20060270670A1,CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CNCC(=O)OC(C)(C)C>>CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CNC,,CCOC(C)=O,CO,Cl,[Na+].[OH-],val
US20040138277A1,CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccccc1.Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccccc3-c3ccccc3)oc2C)cc1>>CCOC(=O)C(C)(Cc1ccc(OCCc2nc(-c3ccc(-c4ccccc4)cc3)oc2C)cc1)Oc1ccccc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090131458A1,BrCC1CCCCO1.CCCCNc1nc(N)c2nc(OC)[nH]c2n1>>CCCCNc1nc(N)c2nc(OC)n(CC3CCCCO3)c2n1,,CCOC(C)=O,CN(C)C=O,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20060025433A1,N#Cc1cnc(NCc2ccccc2OC(F)(F)F)nc1NC[C@@H]1CC[C@@H](N)CC1.NC(=O)CBr>>N#Cc1cnc(NCc2ccccc2OC(F)(F)F)nc1NC[C@@H]1CC[C@@H](NCC(N)=O)CC1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20160137637A1,Nc1ncn[nH]1.O=C(O)c1csc(-c2ccc3c(c2)CCO3)n1.c1ccncc1>>O=C(Nc1nc(-c2ccncc2)n[nH]1)c1csc(-c2ccc3c(c2)CCO3)n1,,c1ccncc1,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20110257198A1,Cc1ccc(O)c(CO[Si](C)(C)C(C)(C)C)n1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1ccc(OS(=O)(=O)C(F)(F)F)c(CO[Si](C)(C)C(C)(C)C)n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080255083A1,Cc1cccnc1CCl.O=c1cc(O)ccn1CCc1ccc(CO)cc1>>Cc1cccnc1COc1ccn(CCc2ccc(CO)cc2)c(=O)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06066639,COC(=O)c1cccn1[Si](C(C)C)(C(C)C)C(C)C.O=C1CCC(=O)N1I>>COC(=O)c1cc(I)cn1[Si](C(C)C)(C(C)C)C(C)C,,C1CCOC1,,,,val
US20100075946A1,Cc1cc(CCC(=O)c2cc(-c3ccccc3)c(C)s2)cc(C)c1OCC1CO1.N>>Cc1cc(CCC(=O)c2cc(-c3ccccc3)c(C)s2)cc(C)c1OCC(O)CN,,CO,,,,val
US20160096839A1,COc1cc(-c2cc(Cl)ccc2-c2cnn(C(F)F)c2)ncn1>>Oc1cc(-c2cc(Cl)ccc2-c2cnn(C(F)F)c2)ncn1,,CC(=O)O,,Br,,val
US20150246923A1,N#CC1CCCC1=O.NNCCO>>Nc1c2c(nn1CCO)CCC2,,CCO,,,,val
US20150252030A1,COC(=O)CBr.Cc1ccccc1N>>COC(=O)CNc1ccccc1C,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150175557A1,CC1(C)[C@H](Nc2nc(S(C)(=O)=O)ncc2C#N)C[C@@H]1C(N)=O.CN1C(=O)C(CCN)c2ccccc21>>CN1C(=O)C(CCNc2ncc(C#N)c(N[C@@H]3C[C@H](C(N)=O)C3(C)C)n2)c2ccccc21,,O,,CCN(C(C)C)C(C)C,,val
US20050171356A1,Cc1nc2ccc(O)cc2o1.ClC(Cl)=CCOc1cc(Cl)c(OCCCBr)c(Cl)c1>>Cc1nc2ccc(OCCCOc3c(Cl)cc(OCC=C(Cl)Cl)cc3Cl)cc2o1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130040934A1,Clc1nc(Cl)nc(N2CC3(COC3)C2)n1.FC(F)c1nc2ccccc2[nH]1>>FC(F)c1nc2ccccc2n1-c1nc(Cl)nc(N2CC3(COC3)C2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05093328,CC(O)=S.CN1C[C@H](O)C[C@H]1C(N)=O>>CC(=O)S[C@H]1C[C@@H](C(N)=O)N(C)C1,,CN(C)C=O,ClCCl,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120232056A1,COC(=O)c1ccc2[nH]c(=O)c(Cl)nc2c1.COC[C@H]1CCCN1>>COC[C@H]1CCCN1c1nc2cc(C(=O)OC)ccc2[nH]c1=O,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20160244441A1,Nc1cc(Br)ccn1.O=C(CBr)c1ccco1>>Brc1ccn2cc(-c3ccco3)nc2c1,,CC(C)=O,,,,val
US05310735,O=C(O)CS.O=C(OCCN1CCN(C(=O)[C@@H]2C[C@@H](O)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)CC1)OCc1ccc([N+](=O)[O-])cc1>>CC(=O)S[C@H]1C[C@@H](C(=O)N2CCN(CCOC(=O)OCc3ccc([N+](=O)[O-])cc3)CC2)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040259912A1,COC(=O)c1cc([N+](=O)[O-])ccc1OC(c1ccccc1)c1ccc(Cl)cc1Cl>>COC(=O)c1cc(N)ccc1OC(c1ccccc1)c1ccc(Cl)cc1Cl,[Fe],CCO,O,[Ca+2].[Cl-].[Cl-],,val
US20120149737A1,COC(=O)c1cc(Cl)c(OCc2ccccc2)c(OC2CCCCC2)c1>>O=C(O)c1cc(Cl)c(OCc2ccccc2)c(OC2CCCCC2)c1,,C1COCCO1,,,,val
US04035427,CC(=O)OCc1ccc(C(=O)C(C)(C)C)cc1>>CC(C)(C)C(=O)c1ccc(CO)cc1,,CCO,O,[K+].[OH-],,val
US20110178120A1,O=C(NCc1ccc(Cl)c(Cl)c1)c1cnc(C(=O)NOCc2ccccc2)c(OCc2ccccc2)c1CO>>O=C(NCc1ccc(Cl)c(Cl)c1)c1cnc(C(=O)NO)c(O)c1CO,[Pd],CO,,,,val
US20130172386A1,CC(C)(C)OC(=O)N1CCC(=O)C(F)C1>>CC(C)(C)OC(=O)N1CC[C@H](O)[C@H](F)C1,,C1CCOC1,,[Na+].[OH-],,val
US20070032489A1,CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1C.CCc1cc(C(=O)NNC(=O)CNC(=O)OC(C)(C)C)c(C)[nH]c1=O>>CCc1cc(-c2nnc(CNC(=O)OC(C)(C)C)o2)c(C)nc1OC,,C1CCOC1,,Cc1ccc(S(=O)(=O)Cl)cc1,,val
US20050032786A1,CC(C)(C)OC(=O)CCc1cc(-c2nc(=O)c3ccccc3s2)nc(S(C)(=O)=O)c1>>CS(=O)(=O)c1cc(CCC(=O)O)cc(-c2nc(=O)c3ccccc3s2)n1,,O=C(O)C(F)(F)F,,CC(C)OC(C)C,,val
US20160096830A1,CC(C)(C)OC(=O)N1CCC[C@H](C(=O)N[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)c2nc3ccccc3s2)C1>>O=C(NCCCC[C@H](NC(=O)[C@H]1CCCNC1)C(=O)c1nc2ccccc2s1)OCc1ccccc1,,CCOC(C)=O,,Cl,,val
US20090124668A1,CCC[C@@H]1CN(C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)OCc2ccccc2)C1=O>>CCC[C@@H]1CN(C(C)C)CC[C@@H]1N1CC[C@H](N)C1=O,[Pd],CO,,[H][H],,val
US04980509,CCc1c(S(=O)(=O)c2ccc3cc(C(=O)c4ccc5c(C)c(OC)cc(C)c5c4)ccc3c2CC)ccc2cc(C(=O)c3ccc4c(C)c(OC)cc(C)c4c3)ccc12>>CCc1c(S(=O)(=O)c2ccc3c(c2CC)C=CC(=Cc2ccc4c(C)c(OC)cc(C)c4c2)C3)ccc2c1C=CC(=Cc1ccc3c(C)c(OC)cc(C)c3c1)C2,[Zn],CC(=O)O,,Cl,,val
US20030153566A1,CC#N.CCN(C(C)C)C(C)C.CCOC(C)=O.COc1ccc(N)cc1[N+](=O)[O-].Cc1ccc(CBr)cc1>>COc1ccc(N(Cc2ccc(C)cc2)Cc2ccc(C)cc2)cc1[N+](=O)[O-],,CC#N,CCOC(C)=O,,,val
US20160211456A1,Brc1ccc2c(c1)C1(c3ccccc3-c3ccccc31)c1cc(Br)ccc1-2.OB(O)c1ccccc1-c1ccccc1>>Brc1ccc2c(c1)C1(c3ccccc3-c3ccccc31)c1ccc(-c3ccccc3-c3ccccc3)cc1-2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20100009985A1,C[C@@]1(c2ccccc2)CCN2CC[C@@](C)(c3ccccc3)c3cc([N+](=O)[O-])cc1c32>>C[C@@]1(c2ccccc2)CCN2CC[C@@](C)(c3ccccc3)c3cc(N)cc1c32,[Pd],C1CCOC1,,,,val
US20050277619A1,CCOP(=O)(Cl)OCC.O=C(O)c1occ(Cl)c1Cl>>CCOP(=O)(OCC)c1oc(C(=O)O)c(Cl)c1Cl,,CCOCC,,CC(C)[N-]C(C)C.[Li+],,val
US20080045518A1,N#C[S-].O=C(CBr)c1ccc(Br)cc1>>N#CSCC(=O)c1ccc(Br)cc1,,CCO,,O,,val
US05366972,COc1ccc(CN2c3ncccc3C(=O)N(C)c3cccnc32)cc1>>CN1C(=O)c2cccnc2Nc2ncccc21,,O=C(O)C(F)(F)F,,,,val
US20090124671A1,CC(CO)c1ncccc1Cl>>CC(C=O)c1ncccc1Cl,,ClCCl,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US20080280906A1,COCCBr.O=C(c1ccc(I)cc1)N1CCCNCC1>>COCCN1CCCN(C(=O)c2ccc(I)cc2)CC1,,CC(=O)N(C)C,,,,val
US05731344,Cc1cc(O)cc(=O)o1.ClCc1ccccc1>>Cc1cc(OCc2ccccc2)cc(=O)o1,,CN(C)C=O,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20110020460A1,Cn1nnnc1-c1ccc(OCc2ccccc2)c(F)c1>>Cn1nnnc1-c1ccc(O)c(F)c1,[Pd],C1CCOC1,CCO,O=CO,,val
US20150322024A1,COC(=O)c1cccc(C=O)c1.O=C(O)CC(=O)O>>COC(=O)c1cccc(/C=C/C(=O)O)c1,,c1ccncc1,,C1CCNCC1,,val
US20080139610A1,Cc1cc(Br)cc(C)c1NC(=O)CC(C)(C)C.FC(F)(F)c1ccc2c(c1)CCNC2>>Cc1cc(N2CCc3cc(C(F)(F)F)ccc3C2)cc(C)c1NC(=O)CC(C)(C)C,,Cc1ccccc1,,Cl,CC(C)(C)[O-].[K+],val
US20160244410A1,COc1ccc(Cn2c(=O)c3c(OS(=O)(=O)C(F)(F)F)cc(=O)n(C)c3n(-c3ccc(I)cc3F)c2=O)cc1.Cc1ccc(O)cn1>>COc1ccc(Cn2c(=O)c3c(Oc4ccc(C)nc4)cc(=O)n(C)c3n(-c3ccc(I)cc3F)c2=O)cc1,,C1CCOC1,,[H-].[Na+],,val
US05114939,Fc1cccc2c(Cl)ccnc12.NCCc1nc(-c2ccccc2)cs1>>Fc1cccc2c(NCCc3nc(-c4ccccc4)cs3)ccnc12,,O,,Cl,[NH4+].[OH-],val
US20050171103A1,CC(=O)OC(C)=O.Nc1ccccc1NC(=O)c1ccc(C2CCNCC2)cc1>>CC(=O)N1CCC(c2ccc(C(=O)Nc3ccccc3N)cc2)CC1,,CC(=O)N(C)C,,,,val
US20140228371A1,COC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Cl)cn1.COc1ccc(O)c(OC)c1>>COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(C(=O)O)nc2)c(OC)c1,,CN1CCCC1=O,CO,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20140315963A1,CC(C)(C)[Si](C)(C)OCCBr.CN(Cc1nc2ccccc2[nH]1)C(=O)Cn1c(=O)sc2ccc(Cl)cc21>>CN(Cc1nc2ccccc2n1CCO[Si](C)(C)C(C)(C)C)C(=O)Cn1c(=O)sc2ccc(Cl)cc21,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05141551,CC(Sc1cc(Oc2c(F)cc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-])C(=O)O>>CC1Sc2cc(Oc3c(F)cc(C(F)(F)F)cc3Cl)ccc2NC1=O,,CC(=O)O,,,,val
US20070037836A1,CN(C)c1nc(NC[C@@H]2CC[C@@H](NC(=O)OCc3ccccc3)CC2)nc2ccccc12.O=S(=O)(Cl)c1ccc(Br)cc1OC(F)(F)F>>CN(C)c1nc(NC[C@@H]2CC[C@@H](NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12,[Pd],CO,ClCCl,CCN(C(C)C)C(C)C,,val
US20060264460A1,Cn1ccnc1C=O.N#Cc1cnc2ccc(N)cc2c1NC1CCCCCC1>>Cn1ccnc1CNc1ccc2ncc(C#N)c(NC3CCCCCC3)c2c1,,CCO,,[BH3-]C#N.[Na+],,val
US20090023731A1,Nc1cccc(OCCCN2CCOCC2)c1.O=C=NC12CC3CC(CC(C3)C1)C2>>O=C(Nc1cccc(OCCCN2CCOCC2)c1)NC12CC3CC(CC(C3)C1)C2,,ClC(Cl)Cl,,,,val
US20120101136A1,COc1cc(OS(=O)(=O)c2ccc(C)cc2)ccc1Br>>COc1cc(O)ccc1Br,,CO,,[Na+].[OH-],,val
US20130116248A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Nc1ncc(Br)cc1C(F)(F)F>>Nc1ncc(B(O)O)cc1C(F)(F)F,,C1COCCO1,CCOC(C)=O,ClCCl,CC(=O)[O-].[K+],val
US06133266,COC(=O)Cc1cc(C2(C)OCCO2)ccc1OCc1ccccc1>>CC1(c2ccc(OCc3ccccc3)c(CCO)c2)OCCO1,,CCOCC,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20140235593A1,NCC(F)(F)F.O=Cc1cccnc1>>FC(F)(F)CN=Cc1cccnc1,,CC#N,,CCN(CC)CC,Cl,val
US20160137636A1,COc1ccc(CNc2ccon2)cc1.O=S(=O)(Oc1c(F)c(F)c(F)c(F)c1F)c1ccc2c(Cl)nc(Cl)cc2c1>>COc1ccc(CN(c2ccon2)S(=O)(=O)c2ccc3c(Cl)nc(Cl)cc3c2)cc1,,Cl,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20130225584A1,BrCc1ccccc1.CCOC(C)=O.CN(C)C=O.O=C(O)c1cc(CN2CCOCC2)c(Br)cc1O.O=C([O-])[O-]>>O=C(OCc1ccccc1)c1cc(CN2CCOCC2)c(Br)cc1OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,O,,val
US20100317568A1,CC(C)(C)c1ccc(N2C(C(=O)O)CCC2C(=O)O)cc1>>CC(C)(C)c1ccc(N2[C@@H](C(=O)O)CC[C@@H]2C(=O)O)cc1,,O,,CC#N,,val
US20150291577A1,Cc1sc(C(=O)O)cc1[C@@H]1C[C@H]1NC(=O)OC(C)(C)C.NC1CCOCC1>>Cc1sc(C(=O)NC2CCOCC2)cc1[C@@H]1C[C@H]1NC(=O)OC(C)(C)C,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05470845,CS(=O)(=O)Cl.Oc1ccccc1>>CS(=O)(=O)Oc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US05538940,COC(=O)/C=C(/OC)c1ccccc1C.O=C1CCC(=O)N1Br>>COC(=O)/C=C(/OC)c1ccccc1CBr,,CO,,,,val
US03956374,CC(=O)C(CCC(=O)O)(Cc1cccc(Cl)c1)c1ccccc1.O=Cc1ccc(Cl)cc1>>O=C(O)CCC(Cc1cccc(Cl)c1)(C(=O)C=Cc1ccc(Cl)cc1)c1ccccc1,,CCO,O,[Na+].[OH-],,val
US06444679B1,C1CCOC1.CCCC(C)CN1CCC(c2cccc(OC)c2)(c2ncc(C(=O)OC)cn2)CC1.CC[Mg]Br>>CCCC(C)CN1CCC(c2cccc(OC)c2)(c2ncc(C(O)(CC)CC)cn2)CC1,,COC(C)(C)C,,,,val
US20070066624A1,Nc1ccc(Oc2ccc(CO)cn2)cc1>>Nc1ccc(Oc2ccc(C=O)cn2)cc1,O=[Mn]=O,CO,ClCCl,,,val
US20140349994A1,COCCCN1CCc2sc(Nc3ncc(F)cn3)nc2-c2c[nH]nc21>>OCCCN1CCc2sc(Nc3ncc(F)cn3)nc2-c2c[nH]nc21,,ClCCl,,BrB(Br)Br,,val
US20130310394A1,O=[N+]([O-])CC(C[N+](=O)[O-])c1cccc([N+](=O)[O-])c1>>NCC(CN)c1cccc(N)c1,O=[Pt]=O,CO,,[H][H],,val
US04960770,CCCCCCc1cc(C(=O)c2ccc(OC)cc2)c(N)s1.O=C(Cl)CCl>>CCCCCCc1cc(C(=O)c2ccc(OC)cc2)c(NC(=O)CCl)s1,,ClC(Cl)Cl,,,,val
US20070275952A1,CC(C)(C)OC(=O)N1CCN(c2nsnc2Cl)CC1.Cl>>Cl.Clc1nsnc1N1CCNCC1,,C1COCCO1,Cl,,,val
US20150023990A1,CCCn1c(COCC)nc2c(N)nc3cc(OC4CCN(C(=O)OC(C)(C)C)CC4)ccc3c21>>CCCn1c(COCC)nc2c(N)nc3cc(OC4CCNCC4)ccc3c21,,Cl,,,,val
US05998433,COC(=O)c1ccoc1CCOS(C)(=O)=O.NCc1ccccc1>>O=C1c2ccoc2CCN1Cc1ccccc1,,CC#N,,CCN(C(C)C)C(C)C,O,val
US20040229917A1,COCCO.Cc1cc(C#Cc2cn(-c3cncc(Cl)n3)c(C)n2)ccn1>>COCCOc1cncc(-n2cc(C#Cc3ccnc(C)c3)nc2C)n1,,C1CCOC1,,[H-].[Na+],,val
US20150284381A1,CC1CCC(O)(c2ccnc(Cl)c2)CC1>>CC1CC=C(c2ccnc(Cl)c2)CC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100063078A1,Cl.Clc1ccc2c(c1)CCC21CCNC1.O=c1[nH]c(=O)n(CCCCCl)cc1-c1cccs1>>Cl.O=c1[nH]c(=O)n(CCCCN2CCC3(CCc4cc(Cl)ccc43)C2)cc1-c1cccs1,,CN1CCCC1=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20130116235A1,Cn1cc(Br)cc(Nc2cnc(N3CCN(C(=O)OC(C)(C)C)CC3)cn2)c1=O>>Cn1cc(Br)cc(Nc2cnc(N3CCNCC3)cn2)c1=O,,C1COCCO1,Cl,,,val
US20150329538A1,Nc1c(O)ccnc1O.O=C(O)c1cccc2ccc(Oc3ccccc3)nc12>>O=C(Nc1c(O)ccnc1O)c1cccc2ccc(Oc3ccccc3)nc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140107096A1,N#Cc1ccc(OCC(=O)O)cc1.O=C(Cl)C(=O)Cl>>N#Cc1ccc(OCC(=O)Cl)cc1,,ClCCl,,CN(C)C=O,,val
US20090181963A1,CC(C)n1nnc2c(N3CCOCC3)nc(-c3ccc(N)cc3)nc21.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[NH4+]>>CC(C)n1nnc2c(N3CCOCC3)nc(-c3ccc(NC(N)=O)cc3)nc21,,ClCCl,,CCN(CC)CC,,val
US04833146,CC(=O)CCl.Cn1c(=O)[nH]c(=O)c2[nH]cnc21>>CC(=O)Cn1cnc2c1c(=O)[nH]c(=O)n2C,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US03933841,Nc1ccc2nc(Oc3ccccc3)sc2c1.S=C(Cl)Cl>>S=C=Nc1ccc2nc(Oc3ccccc3)sc2c1,,C1COCCO1,,O,,val
US20070049581A1,CC(C)(C)OC(=O)COC1CCNCC1.O=C1CCN(C(=O)OCc2ccccc2)CC1>>CC(C)(C)OC(=O)COC1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1,,C1CCOC1,CCOC(C)=O,[Na+].[OH-],,val
US20130039906A1,Cn1ccc(-c2nn(COCC[Si](C)(C)C)c3cnc(-c4cccnc4)cc23)n1>>Cn1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)n1,,C1COCCO1,,Cl,,val
US20080032967A1,CC(C)(C)OC(=O)Nc1ccc(O)c2ccccc12.ClCCBr>>CC(C)(C)OC(=O)Nc1ccc(OCCCl)c2ccccc12,,CC#N,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20150072977A1,NC(=NO)c1cc(OCc2ccccc2)c(OCc2ccccc2)c([N+](=O)[O-])c1.O=C(O)c1cccnc1C(F)(F)F>>O=[N+]([O-])c1cc(-c2noc(-c3cccnc3C(F)(F)F)n2)cc(OCc2ccccc2)c1OCc1ccccc1,,C1CCOC1,CN(C)C=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080032972A1,Clc1cccc(OC2CCNc3ncc(Br)cc32)c1.OB(O)c1ccc(N2CCOCC2)cc1>>Clc1cccc(OC2CCNc3ncc(-c4ccc(N5CCOCC5)cc4)cc32)c1,,CCCCCC,CCOC(C)=O,,,val
US05102890,CC(=O)NCCCCC(=O)O.O=C1c2ccccc2C(Cl)N1c1ccc2ccc(Cl)nc2n1>>CC(=O)NCCCCC(=O)OC1c2ccccc2C(=O)N1c1ccc2ccc(Cl)nc2n1,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US05594023,CNC1(CC2CCCCC2)C(=O)N(S(=O)(=O)c2ccc([N+](=O)[O-])cc2OC)c2ccc(Cl)cc21>>CNC1(CC2CCCCC2)C(=O)N(S(=O)(=O)c2ccc(N)cc2OC)c2ccc(Cl)cc21,[Ni],C1CCOC1,,CO,,val
US04599344,CCO.Clc1ccc(CC=C2CN3CCC2CC3)cc1.O=S1(=O)CCCO1>>O=S(=O)(O)CCC[N+]12CCC(CC1)C(=CCc1ccc(Cl)cc1)C2.[OH-],,CCO,,,,val
US20070082907A1,COC(O[Si](C)(C)C)=C(C)C.COc1ccc(COC(C)=O)c(C)c1>>COC(=O)C(C)(C)Cc1ccc(OC)cc1C,,ClCCl,,,,val
US20090155209A1,CC(C)(C)OC(=O)N[C@H]1CCCOCC=C[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2CC2)NC(=O)[C@@H]2C[C@@H](OC(=O)N3Cc4cccc(Cl)c4C3)CN2C1=O.Cl>>Cl.N[C@H]1CCCOCC=C[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2CC2)NC(=O)[C@@H]2C[C@@H](OC(=O)N3Cc4cccc(Cl)c4C3)CN2C1=O,,C1COCCO1,ClCCl,,,val
US20050124679A1,COC(=O)c1ccc(CS(=O)(=O)Cl)cc1.Nc1cccnc1>>COC(=O)c1ccc(CS(=O)(=O)Nc2cccnc2)cc1,,ClC(Cl)Cl,ClCCl,CCN(CC)CC,,val
US07511077B2,CC(C)(C)OC(=O)NCC=CCN.O=C(O)CCCCC(c1ccc(F)cc1)c1ccc(F)cc1>>CC(C)(C)OC(=O)NCC=CCNC(=O)CCCCC(c1ccc(F)cc1)c1ccc(F)cc1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20100273779A1,COc1ccc(C(=O)CCC(=O)O)cc1.NNc1ccccn1>>COc1ccc(C2=NN(c3ccccn3)C(=O)CC2)cc1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20090069337A1,O=c1ccc2cccc([N+](=O)[O-])c2[nH]1>>Nc1cccc2ccc(=O)[nH]c12,[Pd],CO,,,,val
US06638945B1,CCOC(=O)c1cnc2cc(OC)c(OC)cc2c1Cl>>COc1cc2ncc(C(=O)O)c(Cl)c2cc1OC,,CCO,O,Cl,[Na+].[OH-],val
US04333937,COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC.Clc1nc2ccccc2s1>>COc1cc2nc(N3CCN(c4nc5ccccc5s4)CC3)nc(N)c2cc1OC,,CCCCO,,CCN(CC)CC,,val
US20030220498A1,CCCCCC[Mg]Br.COC(=O)c1ccc(Cl)cc1>>CCCCCCc1ccc(C(=O)OC)cc1,,CN1CCCC1=O,,C1CCOC1,,val
US20040248854A1,CCOC(C)OC[C@H]1CCCC(=O)N1CC#CCOCC#N>>N#CCOCC#CCN1C(=O)CCC[C@@H]1CO,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060040999A1,C[C@@H]1NC(=O)O[C@@H]1c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Fc1ccc(CCl)c(Cl)c1>>C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1ccc(F)cc1Cl,,C1CCOC1,,[H-].[Na+],,val
US20030065214A1,NCCCC(O)(P(=O)(O)O)P(=O)(O)O.[Na+]>>NCCCC(O)(P(=O)([O-])O)P(=O)(O)O.[Na+],,CCO,,O,,val
US20100029707A1,CC(=O)OC(C)=O.CCc1nn2ccc3c(c2c1CCN)CCO3>>CCc1nn2ccc3c(c2c1CCNC(C)=O)CCO3,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20080207728A1,CCOC(=O)C(N)Cc1c[nH]c2cc(F)c(F)cc12.CNC(=O)c1cc(F)cc(-c2cc3c(c(C(=O)O)c2)OCCCC3)c1>>CCOC(=O)C(Cc1c[nH]c2cc(F)c(F)cc12)NC(=O)c1cc(-c2cc(F)cc(C(=O)NC)c2)cc2c1OCCCC2,,CCN(CC)CC,CN(C)C=O,ClCCCl,On1nnc2ccccc21,val
US20160130253A1,CNC.Clc1cc(-c2ccncc2)c(-c2ccccc2)nn1>>CN(C)c1cc(-c2ccncc2)c(-c2ccccc2)nn1,,CO,,CCOC(C)=O,,val
US20140350032A1,CC(C)C1=C2[C@H]3CC[C@H]4[C@@](C)(CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(=O)OC(C)(C)C)CC[C@@]54C)[C@]3(C)CC[C@@]2(/C=C/C(=O)N[C@H](C)c2ccccc2Cl)CC1=O>>CC(C)C1=C2[C@H]3CC[C@H]4[C@@](C)(CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(=O)O)CC[C@@]54C)[C@]3(C)CC[C@@]2(/C=C/C(=O)N[C@H](C)c2ccccc2Cl)CC1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US06166049,O=C(Cl)C(=O)Cl.O=C(O)COCC(F)(F)F>>O=C(Cl)COCC(F)(F)F,CN(C)C=O,ClCCl,,,,val
US04806141,COS(=O)(=O)OC.Cc1cc(C)c(C=O)c(O)c1>>COc1cc(C)cc(C)c1C=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110245224A1,CC(=O)c1cc(C(O[SiH2]C(C)(C)C)(c2ccccc2)c2ccccc2)c(N2C[C@H](C)O[C@H](C)C2)c(F)c1F>>CC(=O)c1cc(CO)c(N2C[C@H](C)O[C@H](C)C2)c(F)c1F,,C1COCCO1,,Cl,O,val
US20080269208A1,CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(Cl)cc1I.OB(O)c1ccc(F)cc1Cl>>CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(Cl)cc1-c1ccc(F)cc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20110003822A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1cc(Br)cc(C(=O)O)c1>>COC(=O)c1cc(Br)cc(C(=O)OC(C)(C)C)c1,CN(C)c1ccncc1,C1CCOC1,,,,val
US04460588,CC(=O)Nc1ccc(OCCO)cc1.Clc1cnc(Cl)nc1>>CC(=O)Nc1ccc(OCCOc2ncc(Cl)cn2)cc1,,C1CCOC1,,[H-].[Na+],,val
US04394329,CC(C)=O.CCOC(=O)C(CO)(CO)C(=O)OCC>>CCOC(=O)C1(C(=O)OCC)COC(C)(C)OC1,,c1ccccc1,,O=P(O)(O)O,,val
US04670604,CC(=O)OC(COc1ccc(C)c(N)c1)COc1ccc(C(C)=O)c(O)c1CCC(F)(F)F.CCN(CC)CC.COC(=O)C(=O)Cl>>CCOC(=O)C(=O)Nc1cc(OCC(COc2ccc(C(C)=O)c(O)c2CCC(F)(F)F)OC(C)=O)ccc1C,,ClCCl,,,,val
US20110288097A1,C[Si](C)(C)CCOCn1cc(C(=O)NC2CCCN(S(C)(=O)=O)C2)c2nc(C3CC3)cnc21>>CS(=O)(=O)N1CCCC(NC(=O)c2c[nH]c3ncc(C4CC4)nc23)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05164397,CCN(CC)CC.ClC(c1ccccc1)(c1ccccc1)c1ccccc1.ClCCl>>CN(CCCl)C(c1ccccc1)(c1ccccc1)c1ccccc1,,O,,,,val
US20080269193A1,N#Cc1c(F)c(F)c(F)c(F)c1F.NN>>N#Cc1c(F)c(F)c(NN)c(F)c1F,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20150274704A1,CC(C)(C)OC(=O)N1CCCC2(CC=CC2)C1=O.OO>>CC(C)(C)OC(=O)N1CCCC2(CCC(O)C2)C1,,C1CCOC1,,[Na+].[OH-],,val
US04426381,C1CNCCN1.O=C(O)c1c2n(c3ccc(Cl)c(Cl)c3c1=O)CCS2>>O=C(O)c1c2n(c3ccc(Cl)c(N4CCNCC4)c3c1=O)CCS2,,c1ccncc1,,,,val
US04060636,CCCCN.CCCCNc1ccc(C(=O)c2ccccc2)cc1[N+](=O)[O-].O=C(c1ccccc1)c1ccc(Cl)c([N+](=O)[O-])c1>>CCCCN(c1cccc(C(=O)c2ccccc2)c1)[N+](=O)[O-],,Cc1ccccc1,,O,,val
US20140235863A1,CC(=O)c1ccc(C=NNC(N)=S)c(N)c1.O=C(CBr)c1ccc(F)cc1>>CC(=O)c1ccc(C=NNc2nc(-c3ccc(F)cc3)cs2)c(N)c1,,C1CCOC1,,,,val
US20090111776A1,CN(C)c1cc(NC(=O)[C@@H]2CCCN2C(=O)OCc2ccccc2)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O>>CN(C)c1cc(NC(=O)[C@@H]2CCCN2)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O,[Pd],CO,,,,val
US20120214837A1,CNc1nc2cc3c(cc2cc1CCl)OCO3.COc1cc2cc(O)nc(C)c2cc1OC>>CNc1nc2cc3c(cc2cc1Cc1c(O)nc(C)c2cc(OC)c(OC)cc12)OCO3,,Cc1ccccc1,ClCCl,Cl,[K+].[OH-],val
US20160016908A1,CCC1C(C)C(N)c2cc(C(=O)NC)ccc2N1C(C)=O.N#Cc1cnc(Cl)cn1>>CCC1C(C)C(Nc2cnc(C#N)cn2)c2cc(C(=O)NC)ccc2N1C(C)=O,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20150299218A1,O=[N+]([O-])c1cccc(C2OCCc3c2[nH]c2ccccc32)c1>>Nc1cccc(C2OCCc3c2[nH]c2ccccc32)c1,[Pd],CO,,,,val
US20040039061A1,CCC(N)CC.COc1c(C)c(Cc2ccc(-c3ccncc3)c(C(=O)O)c2)c(OC)c(OC)c1OC>>CCC(CC)NC(=O)c1cc(Cc2c(C)c(OC)c(OC)c(OC)c2OC)ccc1-c1ccncc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20100173880A1,CCOC(=O)C(Nc1cccc(F)c1)c1cccc(F)c1>>O=C(O)C(Nc1cccc(F)c1)c1cccc(F)c1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20020173518A1,CC(C)(C)OC(=O)n1ncc2ccc(N)cc21.Cc1cccc(C(=O)O)c1[N+](=O)[O-]>>Cc1cccc(C(=O)Nc2ccc3cnn(C(=O)OC(C)(C)C)c3c2)c1[N+](=O)[O-],,CN(C)C=O,,ClCCCl,,val
US05753679,Cc1cccc(C(=O)Cl)c1.OC1CCN(Cc2ccccc2)CC1>>Cc1cccc(C(=O)OC2CCN(Cc3ccccc3)CC2)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20160166560A1,CN(C(=O)Cl)C1CCN(C(=O)OC(C)(C)C)CC1.NC(=O)c1ccc(-c2c[nH]cn2)cc1>>CN(C(=O)n1cnc(-c2ccc(C(N)=O)cc2)c1)C1CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20090286782A1,COc1ncnc2[nH]ccc12.O=C1CCC(=O)N1I>>COc1ncnc2[nH]cc(I)c12,,ClCCl,,O,,val
US04652652,CCOC(=O)C(C(=O)OCC)c1csc(N)n1.O=CO>>CCOC(=O)C(C(=O)OCC)c1csc(NC=O)n1,,O=CO,,CC(=O)OC(C)=O,,val
US20050015893A1,CC(C)(C)OC(=O)NCCBr.O=[N+]([O-])c1c(Br)n[nH]c1Br>>CC(C)(C)OC(=O)NCCn1nc(Br)c([N+](=O)[O-])c1Br,,CN(C)C=O,,[H-].[Na+],,val
US20160083365A1,COCC(=O)Cl.Nc1ccnc(Cl)n1>>COCC(=O)Nc1ccnc(Cl)n1,,CN(C)C=O,,[H-].[Na+],,val
US07732446B1,CCN(C(C)C)C(C)C.COc1cc(OC)c2c(CNC(=O)OC(C)(C)C)ncc(C(=O)O)c2c1.NCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COc1cc(OC)c2c(CNC(=O)OC(C)(C)C)ncc(NC(=O)N(C)C)c2c1,,CCOC(C)=O,,C1COCCO1,,val
US20030139376A1,CC(O)C(O)C1OC(C)(C)OC1CO.CI.O=C([O-])CI>>COC(=O)COC[C@@H]1OC(C)(C)O[C@@H]1C(O)C(C)O,,O,,[Na+].[OH-],,val
US04863958,CCCc1ccc(OCc2ccccc2)c2c(C)c(C(=O)c3ccc(OC)cc3)oc12>>CCCc1ccc(O)c2c(C)c(Cc3ccc(OC)cc3)oc12,[Pd],CCO,,,,val
US20090298829A1,CC(C)(C)OC(=O)N1CC[C@@H](O)C1.CCOCC.COS(=O)(=O)OC>>C=CC[C@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C,,CCOCC,O,[Li]C(C)CC,,val
US06143779,CC(=O)Cl.COc1cc(C=C2Oc3cc(O)ccc3C2=O)cc(OC)c1>>COc1cc(C=C2Oc3cc(OC(C)=O)ccc3C2=O)cc(OC)c1,,c1ccncc1,,CCOC(C)=O,,val
US06028224,CC(C)(C)O.O=C(O)CCC(=O)c1ccccc1>>CC(C)(C)OC(=O)CCC(=O)c1ccccc1,CN(C)c1ccncc1,c1ccccc1,,CCN(CC)CC,,val
US20110021520A1,C[C@@](O)(CN)c1cc(Br)ccc1F.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>C[C@@](O)(CNS(=O)(=O)c1ccccc1[N+](=O)[O-])c1cc(Br)ccc1F,,C1CCOC1,COC(C)(C)C,[Na+].[OH-],,val
US05412097,CCCCc1nc2ncccc2[nH]1>>c1cnc2[nH]cnc2c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150225405A1,CS(=O)(=O)[C@H]1CCNC1.Cc1nc(Cl)ncc1Br>>Cc1nc(N2CC[C@H](S(C)(=O)=O)C2)ncc1Br,,CCO,,CCN(CC)CC,,val
US20150274705A1,CC(C)(C)OC(=O)N1CCC2(CCC(Nc3nc(Cl)ncc3Cl)CC2)CC1.Cc1c2ccc(N)cc2nn1C>>Cc1c2ccc(Nc3ncc(Cl)c(NC4CCC5(CC4)CCN(C(=O)OC(C)(C)C)CC5)n3)cc2nn1C,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20130190307A1,CC(C)(C)OC(=O)N1CCC(C(=O)NNc2cnc3ccc(Br)cc3n2)CC1>>Brc1ccc2ncc3nnc(C4CCNCC4)n3c2c1,,CC(=O)O,,,,val
US20030092677A1,CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2F)cc1NC(=O)CC(=O)c1ccnc(-n2ccnc2)c1>>O=C1CC(c2ccnc(-n3ccnc3)c2)=Nc2ccc(-c3ccccc3F)cc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04937257,COc1ccc(C2CC(=O)c3cc(O)ccc3O2)cc1.COc1ccc(C=O)cc1>>COc1ccc(C=C2C(=O)c3cc(O)ccc3OC2c2ccc(OC)cc2)cc1,,CCO,,Cl,,val
US20060004043A1,CCOC=CC(=O)Cl.Nc1ccc(Br)cc1>>CCOC=CC(=O)Nc1ccc(Br)cc1,,ClCCl,c1ccncc1,,,val
US06239131B1,CCOC(=O)c1cccc(N)c1.Cc1ccc2c(c1)N(CC(=O)C(C)(C)C)C(=O)C(N)CN2c1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCOC(=O)c1cccc(NC(=O)NC2CN(c3ccccc3)c3ccc(C)cc3N(CC(=O)C(C)(C)C)C2=O)c1,,C1CCOC1,,CCN(CC)CC,,val
US20160159809A1,CS(=O)(=O)Cl.Nc1ccc(-c2nc(NCC(c3ccccc3)c3ccccc3)c3ccccc3n2)cn1>>CS(=O)(=O)Nc1ccc(-c2nc(NCC(c3ccccc3)c3ccccc3)c3ccccc3n2)cn1,,c1ccncc1,,,,val
US20050009841A1,Nc1ccc(Cl)cc1.O=C(O)C1=CCN(c2ncccc2Cl)CC1>>O=C(Nc1ccc(Cl)cc1)C1=CCN(c2ncccc2Cl)CC1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20120101083A1,Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(=O)CBr)C2.Cl.NC(CO)CO>>Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(=O)CNC(CO)CO)C2.Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060293320A1,COC(=O)c1cc(C2CCCCC2)c(-c2ccc3nc(-c4sc(C)nc4C)ccc3c2)n1CC(=O)N1CCOCC1>>Cc1nc(C)c(-c2ccc3cc(-c4c(C5CCCCC5)cc(C(=O)O)n4CC(=O)N4CCOCC4)ccc3n2)s1,,CO,,[Na+].[OH-],,val
US20070299092A1,COCCOc1cc2ncc(C#N)c(Nc3cc(OC)c(OC)c(Cl)c3OC)c2cc1OC>>COCCOc1cc2ncnc(NC3=CC(=O)C(OC)=C(Cl)C3=O)c2cc1OC,,O=C([O-])O,[Na+],CC#N,O,val
US20120035231A1,CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1c1ccc(C(N)=O)c(F)c1.OO>>CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)N1c1ccc(C(N)=O)c(F)c1,,CCO,,,,val
US20160159774A1,C=CC(=O)N1CCC[C@@H](Nc2nc(Nc3ccc4c(c3)CN(CC3CCNCC3)C4)ncc2F)C1.CC(=O)Cl>>C=CC(=O)N1CCC[C@@H](Nc2nc(Nc3ccc4c(c3)CN(C(C)=O)C4)ncc2F)C1,,ClCCl,,,,val
US04803279,NC1=NCCS1.O=C(CCl)c1ccc(F)cc1>>Fc1ccc(-c2cn3c(n2)SCC3)cc1,,O,,CCO,,val
US05654316,CN(C(=O)CC(CCO)c1ccc(Cl)c(Cl)c1)c1ccccc1.CS(=O)(=O)Cl>>CN(C(=O)CC(CCOS(C)(=O)=O)c1ccc(Cl)c(Cl)c1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20140128390A1,CC1(C)OB(c2ccc(N)cc2F)OC1(C)C.COc1cc2c(Cl)ncnc2cc1OCCCN1CCCCC1>>COC1=CC2C(c3ccc(N)cc3F)=NC=NC2C=C1OCCCN1CCCCC1,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20100197655A1,N#Cc1cc(S(=O)(=O)Nc2ncns2)ccc1F.Oc1ccccc1I>>N#Cc1cc(S(=O)(=O)Nc2ncns2)ccc1Oc1ccccc1I,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060257987A1,CCc1ccc(OC)c(Oc2ccccc2C)c1>>CCc1ccc(O)c(Oc2ccccc2C)c1,,ClCCl,,BrB(Br)Br,,val
US20050085487A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1>>O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030069261A1,CC(=O)C(=Cc1cc(F)c(F)c(F)c1)C(C)=O.COC(=N)N>>COC1=NC(C)=C(C(C)=O)C(c2cc(F)c(F)c(F)c2)N1,,CCO,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20110015174A1,CCCCCc1ccc(S(=O)(=O)Cl)cc1.CCOC(=O)CC1(N)CCCN(C)C1>>CCCCCc1ccc(S(=O)(=O)NC2(CC(=O)OC)CCCN(C)C2)cc1,,ClCCl,,CCN(CC)CC,,val
US20110053943A1,CCOC(=O)C1CCCN(C(=O)OC2C3CC4CC(C3)CC2C4)C1.COc1ccccc1CBr>>CCOC(=O)C1(Cc2ccccc2OC)CCCN(C(=O)OC2C3CC4CC(C3)CC2C4)C1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20070281952A1,CC(C)(C)S(=O)/N=C/c1cccnc1S(=O)(=O)c1ccc2cc(-c3ccc(F)cc3)ccc2c1>>CC(C)(C)S(=O)NCc1cccnc1S(=O)(=O)c1ccc2cc(-c3ccc(F)cc3)ccc2c1,,CO,ClCCl,O,[BH4-].[Na+],val
US20090253699A1,CC(C)c1ccc(C(=O)Cl)cc1.COC(=O)c1cccc(C(=O)CN)c1>>COC(=O)c1cccc(C(=O)CNC(=O)c2ccc(C(C)C)cc2)c1,,C1CCOC1,,c1ccncc1,,val
US04908357,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C(NCC(=O)c1cccs1)c1ccc(C(F)(F)F)cc1>>FC(F)(F)c1ccc(-c2ncc(-c3cccs3)s2)cc1,,Cc1ccccc1,,,,val
US06509341B1,COC(c1ccccc1)(c1ccccc1)[C@H](O)C(=O)OCc1ccccc1.O=C(O)CO>>O=C1COC(c2ccccc2)(c2ccccc2)[C@@H](C(=O)OCc2ccccc2)O1,Cc1ccc(S(=O)(=O)O)cc1,ClCCl,,,,val
US20160081334A1,COC1=C(c2c(C)cc(C)cc2C)C(=O)C(CCN)C1.O=C(Cl)c1ccccc1>>COC1=C(c2c(C)cc(C)cc2C)C(=O)C(CCNC(=O)c2ccccc2)C1,,ClCCl,,CCN(CC)CC,,val
US20060264460A1,N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(Cl)c1.O=Cc1cnc(S(=O)(=O)c2ccccc2)s1>>N#Cc1cnc2ccc(NCc3cnc(S(=O)(=O)c4ccccc4)s3)cc2c1Nc1ccc(F)c(Cl)c1,,CCO,,[BH3-]C#N.[Na+],,val
US20050080266A1,CC(C)OB1OC(C)(C)C(C)(C)O1.COCOc1cccc(OC)c1OC>>COCOc1c(B2OC(C)(C)C(C)(C)O2)ccc(OC)c1OC,,CCOCC,,[Li]CCCC,,val
US20050288314A1,N#Cc1c(F)cccc1F.OCc1ccc(Br)cc1>>N#Cc1c(F)cccc1OCc1ccc(Br)cc1,,CN(C)C=O,,[H-].[Na+],,val
US04359470,CC(C)(CF)C(=O)CBr.Oc1ccc(Cl)cc1Cl>>CC(C)(CF)C(=O)COc1ccc(Cl)cc1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140088101A1,COC(=O)C=CC(C(=O)OC)=C(C)NCc1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Br)c(=O)n(Cc2ccccc2)c1C,,CO,,C[O-].[Na+],,val
US20150329538A1,CC1(N)CC1.O=c1c2ccc(F)c(Br)c2nc(Cl)n1C1CC1>>CC1(Nc2nc3c(Br)c(F)ccc3c(=O)n2C2CC2)CC1,,CS(C)=O,O,CCN(CC)CC,Cl,val
US04170956,CCCCCCCCCCCCCC(=O)O.Nc1ccccc1>>CCCCCCCCCCCCCC(=O)Nc1ccccc1,,Cc1ccccc1C,,,,val
US05606037,CS(=O)(=O)Cl.C[C@@H]1OC(O)C[C@H](NC(=O)C(F)(F)F)[C@@H]1O>>C[C@@H]1OC(O)C[C@H](NC(=O)C(F)(F)F)[C@@]1(O)S(C)(=O)=O,,ClCCl,,CCN(CC)CC,Cl,val
US20150225412A1,CC(C)(C)OC(=O)N1CC(Cn2c(NC(=O)c3ccc(C(F)F)s3)nc3ccccc32)C1>>O=C(Nc1nc2ccccc2n1CC1CNC1)c1ccc(C(F)F)s1,,ClCCl,O=C(O)C(F)(F)F,,,val
US04891363,C1=COCCC1.O[C@@H]1CCCO[C@H]1COCc1ccccc1>>c1ccc(COC[C@@H]2OCCC[C@H]2OC2CCCCO2)cc1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20160235716A1,COc1cccc2c1CCC21NC(=O)N(CC(=O)OC(C)(C)C)C1=O>>COc1cccc2c1CCC21NC(=O)N(CC(=O)O)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050107449A1,CCOC(=O)Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CC.CI>>CCOC(=O)C(C)c1nc(-c2ccc(C(F)(F)F)cc2)sc1CC,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20150322087A1,BrCc1ccccc1.COC(=O)[C@H]1NC(=O)N2[C@@H]1SC(C)(C)[C@@H]2C(=O)OC>>COC(=O)[C@@H]1[C@H]2SC(C)(C)[C@H](C(=O)OC)N2C(=O)N1Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080188531A1,NNC(=O)c1ccc([N+](=O)[O-])cc1.O=C(n1ccnc1)n1ccnc1>>O=[N+]([O-])c1ccc(-c2nnc(O)o2)cc1,,CN(C)C=O,ClCCl,CCN(CC)CC,,val
US20070043180A1,C=Cc1cccc(Cl)c1O.CCOCC.CN(C)C=O>>C=Cc1cccc(Cl)c1OC(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070213338A1,Nc1nnc(Cl)c2ccccc12.O=C(CBr)C(F)(F)F>>FC(F)(F)c1cn2nc(Cl)c3ccccc3c2n1,,CCO,,,,val
US20150225394A1,CC(=O)O.CC1(C=O)CCN(C(=O)OC(C)(C)C)CC1.ClCCCl.N[C@@H]1C[C@H]1c1ccccc1>>CC1(CN[C@@H]2C[C@H]2c2ccccc2)CCN(C2(CC(=O)O)CCC2)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110237578A1,Cc1ccc(-c2cc(C(=O)O)cc(N3CCCC3=O)c2)cc1.Cc1ccc(CN)cn1>>Cc1ccc(-c2cc(C(=O)NCc3ccc(C)nc3)cc(N3CCCC3=O)c2)cc1,,CN(C)C=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100280219A1,CN(C)c1cccc2c(S(=O)(=O)Cl)cccc12.NCCO>>CN(C)c1cccc2c(S(=O)(=O)NCCO)cccc12,,ClCCl,,CCN(CC)CC,,val
US20030203904A1,Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(NC(=O)c3ccco3)cc(-c3cccc(Cl)c3)c2c1.O=C=Nc1ccccc1>>Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(NC(=O)Nc3ccccc3)cc(-c3cccc(Cl)c3)c2c1,O,C1CCOC1,,,,val
US20130123438A1,C=C(C)C(=O)OCCCCCCCCOC(=O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1>>C=C(C)C(=O)OCCCCCCCCOC(=O)c1cc(N)cc(N)c1,,CCO,,C1CCOC1,[Na+].[OH-],val
US20020147200A1,C1CNCCN1.CC(Oc1cncc(Cl)n1)c1ccccc1>>CC(Oc1cncc(N2CCNCC2)n1)c1ccccc1,,CC#N,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20160083379A1,CNc1ccc(OC)cc1.O=C(Cl)Cc1ccccc1>>COc1ccc(N(C)C(=O)Cc2ccccc2)cc1,,ClCCl,,,,val
US20150087639A1,CC(=O)C=C=O.CC(C)(Cc1ccc2ccccc2c1)Nc1ccc(N)cc1Cl>>CC(=O)CC(=O)Nc1ccc(NC(C)(C)Cc2ccc3ccccc3c2)c(Cl)c1,,CCOC(C)=O,,,,val
US20130130378A1,COc1ccc(C(OC[C@@H](O)Cn2cnc3c(OCc4ccccc4)nc(N)nc32)(c2ccccc2)c2ccc(OC)cc2)cc1>>COc1ccc(C(OC[C@@H](O)Cn2cnc3c(=O)[nH]c(N)nc32)(c2ccccc2)c2ccc(OC)cc2)cc1,[Pd],CO,,,,val
US07947690B2,CC(C)(C)OC(=O)N1Cc2nc(-c3cc(F)c(Cl)cc3F)[nH]c(=O)c2C1.Cl>>Cl.O=c1[nH]c(-c2cc(F)c(Cl)cc2F)nc2c1CNC2,,CCOC(C)=O,,CO,ClC(Cl)Cl,val
US20080139580A1,CCCc1c(Cn2ccnc2-c2cccc(F)n2)nc(C)nc1N=[N+]=[N-]>>CCCc1c(N)nc(C)nc1Cn1ccnc1-c1cccc(F)n1,[Pd],CO,,,,val
US04391627,COc1nc(C)nc(N)n1.O=C=NS(=O)(=O)c1csc2ccccc12>>COc1nc(C)nc(NC(=O)NS(=O)(=O)c2csc3ccccc23)n1,,CC#N,,,,val
US04062861,CI.CN(C)C(=O)Nc1cc(C(C)(C)C)on1>>CN(C)C(=O)N(C)c1cc(C(C)(C)C)on1,,CN(C)C=O,,[H-].[Na+],,val
US04086238,C=CCN.COCC(Cl)C=O>>C=CCNC(C=O)COC,,Cc1ccccc1,,,,val
US20100210610A1,COC(=O)Cc1c(C)[nH]c2ncccc12.CS(=O)(=O)c1ccc(CBr)c(Cl)c1>>Cc1c(CC(=O)O)c2cccnc2n1Cc1ccc(S(C)(=O)=O)cc1Cl,,CN(C)C=O,,[H-].[Na+],,val
US07629375B2,COCOc1cc(CO)cc(OCOC)c1CC=C(C)C.CS(=O)(=O)[O-]>>COCOc1cc(COS(C)(=O)=O)cc(OCOC)c1CC=C(C)C,,ClCCl,,CCN(CC)CC,,val
US04956372,O=C(O)c1ccc(Cl)c2c1NCCS2=O>>O=C(O)c1ccc(Cl)c2c1NCCS2,,CO,,CCOC(C)=O,,val
US20030236282A1,CC(C)(C)OC(=O)N1CCC(CNc2ccccc2N)CC1.Nc1c(Cl)cc(CC(C=O)CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)cc1C(F)(F)F>>Nc1c(Cl)cc(CC(CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)c2nc3ccccc3n2CC2CCNCC2)cc1C(F)(F)F,,CN(C)C=O,ClCCl,O=C(O)C(F)(F)F,,val
US20130172360A1,CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ncc(C#Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1>>CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ncc(CCc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1,[Pd],C1CCOC1,CO,,,val
US20080139577A1,Nc1ncc([N+](=O)[O-])s1.O=C(Br)CBr>>O=C(CBr)Nc1ncc([N+](=O)[O-])s1,,CCOC(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20130116258A1,N.N#Cc1ncc(N2C(=O)C3(CCC3)N(c3ccc(C(=O)O)c(F)c3)C2=S)cc1C(F)(F)F>>N#Cc1ncc(N2C(=O)C3(CCC3)N(c3ccc(C(N)=O)c(F)c3)C2=S)cc1C(F)(F)F,,CO,ClCCl,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20140275049A1,CN(C)C=O.COC(=O)c1ccc(-c2cc(-c3cc(I)cc(C(C)(C)C)c3)n(-c3ccc(C(=O)N(C)C)cc3)n2)cc1.COC(=O)c1ccc(-c2cc(-c3cc(SC(C)C)cc(C(C)(C)C)c3)n(-c3ccc(C(=O)N(C)C)cc3)n2)cc1>>COC(=O)c1ccc(-c2cc(-c3cc(SC(C)C)cc(C(C)(C)C)c3)n(-c3ccc(C(=O)N4CCN(C)CC4)cc3)n2)cc1,[Zn],CN(C)C=O,,,,val
US20070293475A1,COCCl.O=C(N1CCc2ccccc2CC1)C(F)(F)F>>O=C(N1CCc2ccc(CCl)cc2CC1)C(F)(F)F,,ClCCl,,Cl[Sn](Cl)(Cl)Cl,,val
US20120252807A1,CN(Cc1ccccc1)C(=O)C1CCN(C(=O)c2cc3ccccc3[nH]2)CC1.COc1ccc(CBr)cc1>>COc1ccc(Cn2c(C(=O)N3CCC(C(=O)N(C)Cc4ccccc4)CC3)cc3ccccc32)cc1,,C1CCOC1,O,[H-].[Na+],,val
US20080015222A1,COc1cc(NC(=O)Cn2cnc3cccc(C(=O)O)c32)cc(OC)c1>>COc1cc(NC(=O)Cn2cnc3cccc(CO)c32)cc(OC)c1,,C1CCOC1,,,,val
US09133148B2,FC(F)(F)c1ccc(CN2CCNCC2)c(N2CCOCC2)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OC(C(F)(F)F)C(F)(F)F>>O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(C(F)(F)F)cc2N2CCOCC2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20030008861A1,O=C(O)C1C2CCCCC2CN1S(=O)(=O)c1cc(Cl)cc(Cl)c1.O=S(Cl)Cl>>O=C(Cl)C1C2CCCCC2CN1S(=O)(=O)c1cc(Cl)cc(Cl)c1,CN(C)C=O,ClCCl,,,,val
US20060122065A1,CCOC(=O)C=Cc1cc(F)c(OCc2ccccc2)c(OC)c1>>CCOC(=O)CCc1cc(F)c(O)c(OC)c1,[Pd],CCO,,Cl,,val
US20130059849A1,CCOC(=O)c1cc(C(C)(C)C)nc2c1c(C)nn2C(C)(C)C>>Cc1nn(C(C)(C)C)c2nc(C(C)(C)C)cc(C(=O)O)c12,,CCO,,[Na+].[OH-],,val
US20130317023A1,Nc1ccc(F)c(Nc2ncccc2-c2ncnc3c2ncn3C2CCCCO2)c1F.O=S(=O)(Cl)c1cccc2c1OCC2>>O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3c2ncn3C2CCCCO2)c1F)c1cccc2c1OCC2,,ClCCl,,c1ccncc1,,val
US20090264433A1,CC(=O)c1cc(Br)c(O)c(Br)c1.O=[Se]=O>>O=CC(=O)c1cc(Br)c(O)c(Br)c1,,C1COCCO1,,O,,val
US20130237525A1,FCCI.O=Cc1cccc(O)c1>>O=Cc1cccc(OCCF)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130131016A1,C=C(c1cc(Cl)c(OC)c(Cl)c1)C(F)(F)F.CC1(C)OB(O)c2ccc(C(Cl)=NO)cc21>>COc1c(Cl)cc(C2(C(F)(F)F)CC(c3ccc4c(c3)C(C)(C)OB4O)=NO2)cc1Cl,,CN(C)C=O,,,,val
US05998433,CN(C)Cc1cc2c(o1)CCN(CCCCCCc1ccccc1)C2=O.Cl>>CN(C)Cc1cc2c(o1)CCN(CCCCCCc1ccccc1)C2=O.Cl,,CO,,,,val
US20040248765A1,C1CCOC1.CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCCCNc1cccc2c1C(=O)c1ccccc1C2=O.CCN(CC)CC.O=C(O)C(F)(F)F>>CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCCCNc1cccc2c1C(=O)c1ccccc1C2=O.O=C(O)C(F)(F)F,,C1CCOC1,,,,val
US20080318943A1,CCCC[Sn](Cl)(CCCC)CCCC.COc1ccc(OC)nn1>>CCCC[Sn](CCCC)(CCCC)c1cc(OC)nnc1OC,,C1CCOC1,CCOCC,[Li]CCCC,[Cl-].[NH4+],val
US05001113,CCCCI.O=C1CCCCN1>>CCCCN1CCCCC1=O,,CN(C)C=O,,[H-].[Na+],,val
US20050054819A1,Cn1ccnc1SCCC1(CO[Si](C)(C)C(C)(C)C)CCC1>>Cn1ccnc1SCCC1(CO)CCC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160263122A1,O=C(CN1CCOCC1)Nc1cc(NC(=O)c2ccc(Cl)nc2)ccc1OC(F)(F)F.OB(O)c1ccccc1F>>O=C(CN1CCOCC1)Nc1cc(NC(=O)c2ccc(-c3ccccc3F)nc2)ccc1OC(F)(F)F,,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US09309263B2,Cc1nc(OCC2CC2)cnc1C(=O)Nc1ccc2c(c1)[C@@]1(C)N=C(NC(=O)OC(C)(C)C)C(C)(C)S(=O)(=O)[C@@H]1CCO2>>Cc1nc(OCC2CC2)cnc1C(=O)Nc1ccc2c(c1)[C@@]1(C)N=C(N)C(C)(C)S(=O)(=O)[C@@H]1CCO2,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04017636,CCOC(=O)[C@H](CCC(=O)O)NC(=O)OCc1ccccc1.O=C1CCC(=O)N1O>>CCOC(=O)[C@H](CCC(=O)ON1C(=O)CCC1=O)NC(=O)OCc1ccccc1,,C1COCCO1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20070232645A1,CC(=O)Nc1ccc(O)cc1.O=[N+]([O-])c1cc(F)cc(F)c1>>CC(=O)Nc1ccc(Oc2cc(F)cc([N+](=O)[O-])c2)cc1,,CS(C)=O,O,C1CCOC1,CC(C)(C)[O-].[K+],val
US20090036422A1,CC(=O)O[C@H](C(=O)N(CCc1ccc(F)cc1)c1ccc(C)c(C)c1)c1ccccc1>>Cc1ccc(N(CCc2ccc(F)cc2)C(=O)[C@@H](O)c2ccccc2)cc1C,,C1CCOC1,O,[Li+].[OH-],,val
US20070155737A1,COC(=O)C(=O)CC(C)=O.Nc1nc(C(=O)O)n[nH]1>>COC(=O)c1cc(C)nc2ncnn12,,CC(=O)O,,,,val
US20120015907A1,CN.CS(=O)(=O)OS(C)(=O)=O.Nc1nc2oc(-c3ccc(F)cc3)c(C(=O)O)c2cc1I>>CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(NS(C)(=O)=O)c(I)cc12,,C1CCOC1,,CCN(CC)CC,,val
US20150094474A1,CC1(C)C(/C=C(\Cl)C(F)(F)F)C1C(=O)Cl.CCOC(=O)C(O)c1cccc(Oc2ccccc2)c1>>CCOC(=O)C(OC(=O)C1C(/C=C(\Cl)C(F)(F)F)C1(C)C)c1cccc(Oc2ccccc2)c1,,Cc1ccccc1,,c1ccncc1,,val
US20100261755A1,CCOC(=O)CC(=O)[C@H]1CCN(C(=O)OC)[C@@H](Cc2ccc(F)c(F)c2)C1.NO>>COC(=O)N1CC[C@H](c2cc(=O)[nH]o2)C[C@@H]1Cc1ccc(F)c(F)c1,,CO,O,Cl,[Na+].[OH-],val
US20150218092A1,BrCCOC1CCCCO1.O=[N+]([O-])c1ccc2[nH]ncc2c1>>O=[N+]([O-])c1ccc2c(cnn2CCOC2CCCCO2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04772600,CCOC(=O)CNc1ncccc1NC(=O)c1ccc(Cl)c(Cl)c1>>CCOC(=O)Cn1c(-c2ccc(Cl)c(Cl)c2)nc2cccnc21,,OCCO,,,,val
US20100256092A1,COc1ccc2c(c1)B(O)OC2>>OB1OCc2ccc(O)cc21,,ClCCl,,BrB(Br)Br,,val
US20060264631A1,CC(C)(C)OC(=O)N1CCN(c2cccc(O)c2[N+](=O)[O-])CC1.CC(C)(C)c1ccc(C=O)cc1>>CC(C)(C)OC(=O)N1CCN(c2cccc3oc(-c4ccc(C(C)(C)C)cc4)nc23)CC1,[Pd],CC(C)O,,N#N,,val
US20150353553A1,Brc1ccccn1.OB(O)C1=CCCCC1>>C1=C(c2ccccn2)CCCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20150152047A1,CCOC(=O)c1ccc(C=O)c(OC(F)(F)F)c1.CN(C(=O)OC(C)(C)C)[C@H]1CCCNC1>>CCOC(=O)c1ccc(CN2CCC[C@H](N(C)C(=O)OC(C)(C)C)C2)c(OC(F)(F)F)c1,,ClCCl,,,,val
US20150111876A1,Cc1nc(COS(C)(=O)=O)c2cc(C3CCC(C)(C)CC3)sc2n1.O=S1(=O)CCNCC1>>Cc1nc(CN2CCS(=O)(=O)CC2)c2cc(C3CCC(C)(C)CC3)sc2n1,,O,,CN(C)C=O,,val
US05484942,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.c1ccc(C2(c3ccccc3)CCSC3CNCC32)cc1>>CC(C)(C)OC(=O)N1CC2SCCC(c3ccccc3)(c3ccccc3)C2C1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,Cl,val
US05001157,NC(=O)c1ccccc1N.O=C(N=C=S)c1ccccc1>>NC(=O)c1ccccc1NC(=S)NC(=O)c1ccccc1,,CCOCC,,,,val
US05599930,CN(c1ncccc1[N+](=O)[O-])C1CCN(OC(C)(C)C)C(=C=O)C1>>CN(c1ncccc1[N+](=O)[O-])C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20060122263A1,NCc1ccccc1.c1ccc(C(c2ccccc2)[C@H]2C[C@@H]3O[C@@H]3CO2)cc1>>O[C@H]1C[C@H](C(c2ccccc2)c2ccccc2)OC[C@@H]1NCc1ccccc1,,CCO,,CO,,val
US20100168418A1,CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCNCC1.Cc1cc(=O)n(CC=O)c2cc(N(C)C)ccc12>>Cc1cc(=O)n(CCN2CCC(N(Cc3ccc4c(c3)OCCO4)C(=O)OC(C)(C)C)CC2)c2cc(N(C)C)ccc12,,CC(=O)O,ClC(Cl)Cl,O=C([O-])O.[Na+],,val
US20090253689A1,CC(C)COc1c(C#N)c(-c2ccc(Cl)cc2Cl)cn2c(Br)cnc12>>CC(C)COc1c(CN)c(-c2ccc(Cl)cc2Cl)cn2c(Br)cnc12,C1COCCO1,C1CCOC1,,B,Cl,val
US05696148,CS(=O)(=O)CC#N.O=Cc1c(Cl)n(Cc2ccccc2)c2ccccc12>>CS(=O)(=O)C(C#N)=Cc1c(Cl)n(Cc2ccccc2)c2ccccc12,,C1CCOC1,,CCN(CC)CC,,val
US09248117B2,CC(C)(C)OCl.CN1CC(C)(CO)NC1=O>>CN1CC(C)(CO)N(Cl)C1=O,,CO,,,,val
US20130053362A1,C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cc2cccc(Cl)c2c(=O)[nH]1.O=S(Cl)Cl>>C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cc2cccc(Cl)c2c(Cl)n1,,Cc1ccccc1,,CN(C)C=O,,val
US04600788,CCCCC(=O)Cl.COc1cccc(NC(C)=O)c1>>CCCCC(=O)c1ccc(NC(C)=O)cc1O,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20020037886A1,BrCCCBr.c1ccc2[nH]nnc2c1>>BrCCCn1nc2ccccc2n1,,CCOC(C)=O,CN(C)C=O,O,[K+].[OH-],val
US20150266871A1,COC(=O)c1c(C)nc(SC)nc1Nc1cccc(C)c1.COC(OC)N(C)C>>COC(=O)c1c(/C=C/N(C)C)nc(SC)nc1Nc1cccc(C)c1,,CN(C)C=O,,O,,val
US20080261977A1,O=C(O)c1cnc(Nc2cccc(Cl)c2)nc1C(F)(F)F>>OCc1cnc(Nc2cccc(Cl)c2)nc1C(F)(F)F,,COCCOC,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US06329389B1,O=C(O)CBr.Oc1ccc(-c2ccccc2)cc1>>O=C(O)COc1ccc(-c2ccccc2)cc1,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20100029643A1,Nc1cc(Cl)c(C(F)(F)F)cc1[N+](=O)[O-]>>Nc1cc(Cl)c(C(F)(F)F)cc1N,Cl[Fe](Cl)Cl,CO,,NN,O,val
US20020019402A1,CCOC(=O)CC(NC(=O)C1CC(=O)N(c2cccc(N)c2)C1)c1cccnc1.O=C(CBr)Nc1ccccc1>>CCOC(=O)CC(NC(=O)C1CC(=O)N(c2cccc(NCC(=O)Nc3ccccc3)c2)C1)c1cccnc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20150291623A1,COCCBr.O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2C12COc1cc(O)ccc12>>COCCOc1ccc2c(c1)OCC21C(=O)N(C(c2ccccc2)c2ccccc2)c2ccccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040127747A1,COC(=O)OC.Nc1ccc(O)cc1>>CNc1ccc(O)cc1,,COCCOC,,,,val
US08304419B2,C=O.C[Si](C)(C)CCOCn1c(Br)nc(Br)c1Br>>C[Si](C)(C)CCOCn1c(CO)nc(Br)c1Br,,C1CCOC1,,[Li]CCCC,,val
US20050165042A1,Oc1ccc2cccnc2c1>>Oc1ccc2c(c1)NCCC2,O=[Pt]=O,C1CCOC1,,CCO,Cl,val
US20160244447A1,COP(=O)(CC(=O)CCCCc1ccc2c(n1)NCCC2)OC.O=Cc1ccc(Cl)c(C(F)(F)F)c1>>O=C(/C=C/c1ccc(Cl)c(C(F)(F)F)c1)CCCCc1ccc2c(n1)NCCC2,,C1CCOC1,CCOC(C)=O,O,CC(C)(C)[O-].[K+],val
US20020052400A1,CCCC(=O)Cl.COc1ccc2c(c1)CC(CN)CO2>>CCCC(=O)NCC1COc2ccc(OC)cc2C1,,ClCCl,,CCN(CC)CC,Cl,val
US20130059856A1,CCOC(=O)c1cnc(CNc2c(F)ccc(F)c2F)n1-c1ccc(F)cc1.CI>>CN(Cc1ncc(C(=O)O)n1-c1ccc(F)cc1)c1c(F)ccc(F)c1F,,CCOC(C)=O,CN(C)C=O,Cl,[H-].[Na+],val
US20130172317A1,CCSc1nc(=O)n(C[C@H](C)C(=O)OC)c(=O)n1Cc1ccc(Cl)cc1.Nc1ccc(Oc2ccccc2)cc1>>COC(=O)[C@@H](C)Cn1c(=O)[nH]c(=Nc2ccc(Oc3ccccc3)cc2)n(Cc2ccc(Cl)cc2)c1=O,,CC(C)(C)O,,CC(=O)O,O=C([O-])O.[Na+],val
US20110312936A1,CN(CC(=O)NC1CN(C(=O)OC(C)(C)C)C1)C(=O)OCc1ccccc1>>CNCC(=O)NC1CN(C(=O)OC(C)(C)C)C1,[Pd],,,,,val
US20150361100A1,CC(c1cc2ccccn2c1-c1ccc(CN(C)C)cc1)n1nc(I)c2c(N)ncnc21.OB(O)c1cc(O)cc(F)c1>>CC(c1cc2ccccn2c1-c1ccc(CN(C)C)cc1)n1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20150238473A1,CC(C)(C)c1ccc(N)cc1.Cc1ccc(S(=O)(=O)OCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1>>CC(C)(C)c1ccc(NCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,,O=C([O-])O,[Na+],CC#N,,val
US05025036,BrCCCCCCBr.COc1cccc(C(C)(C)C)c1OC>>COc1c(CCCCCCBr)ccc(C(C)(C)C)c1OC,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20040204421A1,CCN1CCN(c2nc(-c3ccc(OCC(C)O[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)cc3)cc3sccc23)CC1>>CCN1CCN(c2nc(-c3ccc(OCC(C)O)cc3)cc3sccc23)CC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160068487A1,NC(=S)Nc1cccc(Cl)c1.O=CCCl>>Clc1cccc(Nc2nccs2)c1,,CCO,,,,val
US20030195199A1,CCCCCCC(C)OC(=O)c1sc(N)c(C(=O)OC(C)(C)C)c1C.CCCCCCCCN=C=O>>CCCCCCCCNC(=O)Nc1sc(C(=O)OC(C)CCCCCC)c(C)c1C(=O)OC(C)(C)C,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US20160096827A1,O=[N+]([O-])c1ccc(N2CCOC[C@H]2CO)cc1>>Nc1ccc(N2CCOC[C@H]2CO)cc1,[Pd],CCO,,,,val
US20030130213A1,COC(=O)c1nc(F)cnc1N.N>>NC(=O)c1nc(F)cnc1N,,CO,,,,val
US20140194469A1,COc1cccc(-c2ccnn2-c2cc(C(=O)O)ccn2)c1>>O=C(O)c1ccnc(-n2nccc2-c2cccc(O)c2)c1,,ClCCl,,BrB(Br)Br,,val
US20160272596A1,CC(=O)c1ccc(C(=O)O)cc1.CC(C)(C)OC(=O)N[C@H]1CNc2ccccc2NC1=O>>CC(=O)c1ccc(C(=O)N2C[C@H](NC(=O)OC(C)(C)C)C(=O)Nc3ccccc32)cc1,,O,c1ccncc1,O=P(Cl)(Cl)Cl,,val
US20070054900A1,CN(Cc1nc(-c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cs1)C(=O)OC(C)(C)C>>CNCc1nc(-c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cs1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20120184508A1,CC(C)(C)OC(=O)NC1CCC(Nc2ncc3c(-c4cccc(NCc5cccs5)c4)nn(COCC[Si](C)(C)C)c3n2)CC1>>NC1CCC(Nc2ncc3c(-c4cccc(NCc5cccs5)c4)n[nH]c3n2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140275011A1,Brc1ccc2nc[nH]c2c1.Fc1cccc(CBr)c1>>Fc1cccc(Cn2cnc3cc(Br)ccc32)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120088765A1,COc1ccc(CSc2nc(O)c3nc[nH]c3n2)cc1[N+](=O)[O-].O=P(Cl)(Cl)Cl>>COc1ccc(CSc2nc(Cl)c3nc[nH]c3n2)cc1[N+](=O)[O-],,C1COCCO1,,CN(C)c1ccccc1,,val
US05753661,N#CCCl.c1cc2c(c(N3CCNCC3)c1)OCCO2>>N#CCN1CCN(c2cccc3c2OCCO3)CC1,,CN1CCCC1=O,,CCN(CC)CC,,val
US20120329780A1,CN(C)S(=O)(=O)c1cccc(N)c1.COc1ccc(Cn2cc3nc(-c4cccs4)nc(Cl)c3n2)cc1>>CN(C)S(=O)(=O)c1cccc(Nc2nc(-c3cccs3)nc3cn[nH]c23)c1,C1COCCO1,CO,,Cl,,val
US20160007601A1,CC(=O)OCBr.COc1ccnc(C(=O)N[C@H]2COC[C@H](Cc3ccccc3)[C@@H](Cc3ccccc3)[C@H](C)OC2=O)c1O>>COc1ccnc(C(=O)N[C@H]2COC[C@H](Cc3ccccc3)[C@@H](Cc3ccccc3)[C@H](C)OC2=O)c1OCOC(C)=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05185339,C[Si](C)(C)C#N.[O-][n+]1ccccc1Cc1ccccc1Cl>>N#Cc1cccc(Cc2ccccc2Cl)n1,,CC#N,,CCN(CC)CC,,val
US20120021074A1,C[C@@H](NC(=O)OC(C)(C)C)c1ccc(F)c[n+]1[O-]>>C[C@@H](N)c1ccc(F)c[n+]1[O-],,ClCCl,,C1COCCO1,Cl,val
US20070287699A1,CCOC(=O)/C(C#N)=C/NC1=CCN(C(=O)OCc2ccccc2)CC1>>N#Cc1c[nH]c2c(c1=O)CN(C(=O)OCc1ccccc1)CC2,,c1ccc(Oc2ccccc2)cc1,,,,val
US20050282812A1,CCOC(=O)Cl.CC[C@H]1CN(C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2cc(C(F)(F)F)ccc2N1>>CCOC(=O)N1c2ccc(C(F)(F)F)cc2N(C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)C[C@@H]1CC,,ClCCl,,c1ccncc1,,val
US20070191345A1,Fc1cccc2cc(I)cnc12.O=S([O-])c1ccccc1>>O=S(=O)(c1ccccc1)c1cnc2c(F)cccc2c1,[Cu]I,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080039327A1,CC1CC(C2=C(Cl)C(C(=O)O)=CC(=S(=O)=O)C2C)=NO1.O=S(Cl)Cl>>CC1CC(C2=C(Cl)C(C(=O)Cl)=CC(=S(=O)=O)C2C)=NO1,,Cc1ccccc1,,CN(C)C=O,,val
US20090005376A1,CN(C)C=Nc1cnc2ccccc2c1Cl.CON>>COn1cnc2cnc3ccccc3c21,,CCO,,Cl,,val
US20090069340A1,Cc1c(Cl)c(=O)n(-c2ccc(Cl)cc2)n1C.O=C1CCC(=O)N1Br>>Cn1c(CBr)c(Cl)c(=O)n1-c1ccc(Cl)cc1,,ClC(Cl)(Cl)Cl,,,,val
US20090270369A1,CCOC(=O)NN.CSC1=NCCS1>>CCOC(=O)NN=C1NCCS1,,CCO,,,,val
US05998459,Cc1c(-c2ccccc2)[nH]c(N)c1C#N.O=C(Cl)CCCCl>>Cc1c(-c2ccccc2)[nH]c(N2CCCC2=O)c1C#N,,C1CCOC1,,CCN(CC)CC,,val
US20120010182A1,COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3ccc(-c4ccccc4)cc3-c3ccnnc3)cc2F)c(OC)c1>>O=S(=O)(Nc1nncs1)c1cc(Cl)c(Oc2ccc(-c3ccccc3)cc2-c2ccnnc2)cc1F,,O=C(O)C(F)(F)F,,,,val
US20130317002A1,O=C1CCC(=O)N1Br.c1ccc(-c2cn3ccnc3nc2-c2ccc(CN3CC(c4n[nH]c(-c5ccccn5)n4)C3)cc2)cc1>>Brc1cnc2nc(-c3ccc(CN4CC(c5n[nH]c(-c6ccccn6)n5)C4)cc3)c(-c3ccccc3)cn12,,ClC(Cl)Cl,,,,val
US20150353581A1,CCc1c(OCC(C)(N)C#N)ccc2c1B(O)OC2.O=C(O)c1ccc(OC(F)(F)F)cc1>>CCc1c(OCC(C)(C#N)NC(=O)c2ccc(OC(F)(F)F)cc2)ccc2c1B(O)OC2,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04778796,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ncc(CO)c(C=O)c1O.Cl>>CCOC(=O)C=Cc1c(CO)cnc(C)c1O.Cl,,CCO,,,,val
US20080021053A1,CC(C)(C)OC(=O)CBr.CC1=C(C(=O)c2ccco2)C(c2ccc(C#N)cc2)NC(=O)N1c1cccc(C(F)(F)F)c1>>CC1=C(C(=O)c2ccco2)C(c2ccc(C#N)cc2)N(CC(=O)OC(C)(C)C)C(=O)N1c1cccc(C(F)(F)F)c1,,CN(C)C=O,CO,O=C([O-])[O-].[K+].[K+],,val
US20120264944A1,CNC.COC(=O)c1cnc(Cl)cc1C(F)(F)F>>COC(=O)c1cnc(N(C)C)cc1C(F)(F)F,,O,,,,val
US06166006,N#Cc1cccnc1.O=C(Nc1ccc(CCl)cc1)C1=Cc2cc(-c3ccccc3)ccc2CC1>>N#Cc1ccc[n+](Cc2ccc(NC(=O)C3=Cc4cc(-c5ccccc5)ccc4CC3)cc2)c1.[Cl-],,CN(C)C=O,,,,val
US20140045862A1,Cn1nccc1C1=CCC(C)(C)CC12OCCO2>>Cn1nccc1C1=CCC(C)(C)CC1=O,,C1CCOC1,,Cl,,val
US20140328756A1,FCCBr.N#Cc1ccc2cc(O)ccc2c1>>N#Cc1ccc2cc(OCCF)ccc2c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US07413727B2,CC(C)(C)OC(=O)CCNC(=O)c1ccc2c(c1)C(=O)N(CCNc1ccccn1)C2>>O=C(O)CCNC(=O)c1ccc2c(c1)C(=O)N(CCNc1ccccn1)C2,,ClCCl,,O=C(O)C(F)(F)F,,val
US04369309,CCCNCCC.Cc1ccc(S(=O)(=O)OCC2CCn3c(nc4ccccc43)S2)cc1>>CCCN(CCC)CC1CCn2c(nc3ccccc32)S1,,O,,C1COCCO1,,val
US20130109667A1,CC(C)(C)OC(=O)Nc1cscn1.O=S(=O)(Cl)c1cc(Cl)c(F)cc1F>>CC(C)(C)OC(=O)N(c1cscn1)S(=O)(=O)c1cc(Cl)c(F)cc1F,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20150080362A1,CCc1cc(C(=O)OC)c(=O)n(Cc2ccc(OC)cc2OC)c1-c1ccc(N(C)C)s1>>CCc1cc(C(=O)OC)c(=O)[nH]c1-c1ccc(N(C)C)s1,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20110172442A1,C/C=C/C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC>>C/C=C/C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O,,O,,CO,[Na+].[OH-],val
US20100137317A1,C#CC(C)(C)O[Si](C)(C)C.COc1ccc(C(=O)N(C)OC)cc1C#N>>COc1ccc(C(=O)C#CC(C)(C)O[Si](C)(C)C)cc1C#N,,C1CCOC1,,[Li]CCCC,,val
US05648370,c1ccc(CCOCCSCCC2OCCO2)nc1>>O=CCCSCCOCCc1ccccn1,,O=CO,,,,val
US20020077486A1,COC(=O)c1ccc(NC(=O)NS(=O)(=O)c2ccc(Cl)s2)cc1>>O=C(Nc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc(Cl)s1,,CC#N,CO,[Li+].[OH-],,val
US20040053961A1,CCOC(=O)C1CC2CC(=O)CCC2CN1C(=O)OC.CCOC(C)=O.Nc1ccccc1C(=O)[O-]>>CCOC(=O)c1ccccc1N[C@H]1CC[C@H]2CN(C(=O)OC)[C@H](C(=O)OCC)C[C@H]2C1,,CCCCCC,CCOC(C)=O,CC(=O)O,[Na],val
US20110021537A1,CCOC(=O)N1CCN(C(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)OCc3ccccc3)n(-c3cccc(F)c3)n2)CC1>>CCOC(=O)N1CCN(C(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)O)n(-c3cccc(F)c3)n2)CC1,,CCOC(C)=O,,,,val
US20120142705A1,CSc1ccc2c(c1)N(C(CC1CCCC1)C(=O)Nc1nccs1)C(=O)C2.O=S([O-])OO>>CS(=O)(=O)c1ccc2c(c1)N(C(CC1CCCC1)C(=O)Nc1nccs1)C(=O)C2,,O,,CO,,val
US20040110807A1,CCO[C@H](C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1)[C@H](O)c1ccc(OCc2ccccc2)cc1CC.CO>>CCO[C@H](C(=O)OC)[C@H](O)c1ccc(OCc2ccccc2)cc1CC,,CO,,C[O-].[Na+],,val
US20040157849A1,Cn1ncc2c(N)cccc21.FC(F)(F)c1ccnc(N2CCNCC2)c1.O=C(Cl)Cl>>Cn1ncc2c(NC(=O)N3CCN(c4cc(C(F)(F)F)ccn4)CC3)cccc21,,Cc1ccccc1,,CC(C)NC(C)C,,val
US20050187236A1,CCCCCNC(=O)Oc1ccccc1.Nc1cc(Oc2ccc3[nH]ccc3c2)ccn1>>CCCCCNC(=O)n1ccc2cc(Oc3ccnc(N)c3)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20140243302A1,COc1ccc2ncc(N)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CC4)c2n1.Cl>>COc1ccc2ncc(N)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CC4)c2n1.Cl,,CCO,ClCCl,,,val
US20090270374A1,CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCNCC1.O=CCn1c(=O)sc2ccc(Cl)cc21>>CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCN(CCn2c(=O)sc3ccc(Cl)cc32)CC1,CC(=O)O,ClC(Cl)Cl,,CO,,val
US20150259354A1,CI.N#Cc1c(-c2ccc(Oc3ccccc3)cc2)nn2c(CNC(=O)C(F)(F)F)ccnc12>>CN(Cc1ccnc2c(C#N)c(-c3ccc(Oc4ccccc4)cc3)nn12)C(=O)C(F)(F)F,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040235821A1,NC(=O)c1ccsc1N.O=C=NC(=O)C(Cl)(Cl)Cl>>NC(=O)Nc1sccc1C(N)=O,,CC#N,CO,N,,val
US04008266,c1ccc2c(-c3cccc4ccccc34)cccc2c1.c1ccc2ccccc2c1>>c1ccc2c(-c3ccc4ccccc4c3-c3cccc4ccccc34)cccc2c1,,Cc1ccccc1,,,,val
US20090253677A1,CCOC(=O)c1nc2n(c(=O)c1OC(=O)c1ccccc1)CC1CCC2(N(CC)Cc2ccccc2)CC1>>CCNC12CCC(CC1)Cn1c2nc(C(=O)OCC)c(OC(=O)c2ccccc2)c1=O,[Pd],CO,,Cl,[H][H],val
US05905084,CN1CCC(c2c[nH]c3ccc(O)nc23)CC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)C(F)(F)F)nc23)CC1,,c1ccncc1,,,,val
US04282246,Brc1cccs1.O=C(Cl)c1ccccc1>>O=C(c1ccccc1)c1ccc(Br)s1,,CCOCC,,ClCCl,O,val
US20010051733A1,CC(=O)c1cc(Cl)c2c(c1Cl)C(C)(C)CCS2.OO>>CC(=O)c1cc(Cl)c2c(c1Cl)C(C)(C)CCS2(=O)=O,,CC(=O)O,,O=S([O-])O.[Na+],,val
US20140031338A1,CC(C)(C)OC(C(=O)[O-])c1cc2c(cc1-c1ccc3c(c1)CCCO3)OCCO2>>CC(C)(C)OC(C(=O)O)c1cc2c(cc1-c1ccc3c(c1)CCCO3)OCCO2,,CCO,O,[K+].[OH-],,val
US20110245251A1,NN.O=C1OC(c2ccccc2)C(Br)=C1Br>>O=c1cc(Br)c(-c2ccccc2)n[nH]1,,CCO,,O,,val
US20140349987A1,CC(C)(C)C(=N)N.CCOC(=O)CC(=O)C(C)(C)C>>CC(C)(C)c1cc(O)nc(C(C)(C)C)n1,,CO,O,C[O-].[Na+],,val
US20060025474A1,CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(O)c(C)c2)cc1C)CC.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(OS(=O)(=O)C(F)(F)F)c(C)c2)cc1C)CC,,ClCCl,,O,c1ccncc1,val
US20140200227A1,CO.Clc1ccnc2c1CCC2>>COc1ccnc2c1CCC2,,CCOC(C)=O,Cl,C[O-].[Na+],,val
US20050154038A1,CCS(=O)(=O)CCCC12CCC(C(=O)O)(CC1)CC2.CN>>CCS(=O)(=O)CCCC12CCC(C(=O)NC)(CC1)CC2,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US06166006,Cc1ccc(S(=O)(=O)N2CCC(c3ccccc3)CC2)cc1.ClCC(CCl)OC(CCl)CCl>>Cc1ccc(S(=O)(=O)N2CCC(c3ccc(C=O)cc3)CC2)cc1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20010000511A1,CC(=O)OC(C)=O.CCOC(=O)CC1(O)CCC(C)(C)c2ccc(Br)cc21>>CCOC(=O)CC1(OC(C)=O)CCC(C)(C)c2ccc(Br)cc21,,CCOC(C)=O,ClCCl,,,val
US20140275003A1,Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(S(C)(=O)=O)n1.O=C1CCCN1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCCC2=O)n1,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050203078A1,COC(=O)c1ccc(N)c(C)c1.O=S(=O)(Cl)CCCCl>>COC(=O)c1ccc(NS(=O)(=O)CCCCl)c(C)c1,,c1ccncc1,,CCOC(C)=O,O,val
US20030134838A1,CN.COC(=O)c1cnc(Cl)nc1Cl>>CNc1nc(Cl)ncc1C(=O)OC,,CC(C)=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US06291485B1,CC(C)(C)OC(=O)Nc1cccc(CCl)c1.NN>>CC(C)(C)OC(=O)Nc1cccc(CNN)c1,,CCO,,O,,val
US04680401,Fc1cc(-c2ccno2)c(Cl)cc1Cl>>N#CCC(=O)c1cc(F)c(Cl)cc1Cl,,CCO,,[Na],,val
US20120184587A1,COc1c(C#N)cc(C(=O)Cl)cc1C(F)(F)F.FC(F)(F)c1ccc2c(c1)NCS2>>COc1c(C#N)cc(C(=O)N2CSc3ccc(C(F)(F)F)cc32)cc1C(F)(F)F,,ClCCl,,CCN(CC)CC,O,val
US20050203110A1,CCC(NCCN(C)C)c1nc2cccnc2c(=O)n1Cc1ccccc1.O=C(Cl)c1ccc(Br)cc1>>CCC(c1nc2cccnc2c(=O)n1Cc1ccccc1)N(CCN(C)C)C(=O)c1ccc(Br)cc1,,ClCCCl,,,,val
US05180419,C=CCBr.CC(C)C(C)(C#N)N1C(=O)c2cccc(O)c2C1=O>>C=CCOc1cccc2c1C(=O)N(C(C)(C#N)C(C)C)C2=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130289238A1,BrP(Br)Br.COCCOCc1nc(CO)cs1>>COCCOCc1nc(CBr)cs1,,CCOC(C)=O,CCOCC,,,val
US20150011546A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1nc(C)cc(OC(F)F)c1C#N>>COc1nc(C)cc(OC(F)F)c1CNC(=O)OC(C)(C)C,[Ni],C1CCOC1,,CCN(CC)CC,,val
US20100298356A1,O=C(O)c1cc2cc([N+](=O)[O-])cc(Cl)c2s1>>O=[N+]([O-])c1cc(Cl)c2sccc2c1,[Cu],c1ccc2ncccc2c1,,,,val
US03940395,CCOC(=O)CC(=O)OCC.N=C(N)c1ccccc1>>O=C1CC(=O)NC(c2ccccc2)=N1,,CCO,,[Na],,val
US20100048901A1,CC(=O)OC(C)=O.O=Cc1c[nH]c2ccccc12>>CC(=O)n1cc(C=O)c2ccccc21,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US20070244132A1,Nc1ccc(OCc2cccc(F)c2)c(Cl)c1.OCCn1ccc2ncnc(Cl)c21>>OCCn1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c21,,CN1CCCC1=O,,CCOC(C)=O,,val
US20070021443A1,COc1ccc(CNc2ccc(C#N)cc2N)c(OC)c1.N#CSc1nc(Cl)ncc1[N+](=O)[O-]>>COc1ccc(CNc2ccc(C#N)cc2Nc2ncc([N+](=O)[O-])c(SC#N)n2)c(OC)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080096882A1,O=S1CCc2nc(Cl)nc(Nc3cccc(Cl)c3)c21.O=[N+]([O-])c1ccc(N2CCNCC2)cc1>>O=[N+]([O-])c1ccc(N2CCN(c3nc4c(c(Nc5cccc(Cl)c5)n3)S(=O)CC4)CC2)cc1,,C1COCCO1,,CCN(C(C)C)C(C)C,O,val
US20140128435A1,CCCc1nn(-c2ccc(OC)cc2)c(-c2c(C)noc2C)c1/C=N/O>>CCCc1nn(-c2ccc(OC)cc2)c(-c2c(C)noc2C)c1C=NO,,ClCCl,,BrB(Br)Br,O,val
US05434160,COc1ccc(C=O)cc1OC.N#CCC#N>>COc1ccc(C=C(C#N)C#N)cc1OC,,CCO,,,,val
US20100256386A1,Cc1ccc(-n2nc(C(F)(F)F)nc2N)c(F)c1.O=S(=O)(O)Cl>>Cc1cc(F)c(-n2nc(C(F)(F)F)nc2N)cc1S(=O)(=O)Cl,,CCOC(C)=O,,,,val
US20060052398A1,CC(C)(C)OC(=O)[C@H](CN)NC(=O)OCc1ccccc1.Cc1nc(Cl)c(C)c(N2CCC(c3ccc4c(n3)NCCC4)CC2)n1>>Cc1nc(NC[C@H](NC(=O)OCc2ccccc2)C(=O)OC(C)(C)C)c(C)c(N2CCC(c3ccc4c(n3)NCCC4)CC2)n1,,COCCOC,,[Cs+].[F-],,val
US20110288090A1,COc1nccc2nc(-c3ccc(C(CF)NS(=O)C(C)(C)C)cc3)c(-c3ccccc3)cc12>>NC(CF)c1ccc(-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)cc1,,CO,,,,val
US20110237583A1,CCOC(=O)C1CCNCC1.Clc1ccccc1CNc1ncc2c(Cl)nccc2n1>>CCOC(=O)C1CCN(c2nccc3nc(NCc4ccccc4Cl)ncc23)CC1,,C1CCOC1,,N,O,val
US05538988,COc1ccc(Cn2ccn(C3CCc4ccccc4C3)c2=S)cc1OC>>Oc1ccc(Cn2ccn(C3CCc4ccccc4C3)c2=S)cc1O,,ClCCl,,BrB(Br)Br,O,val
US20150291572A1,C=CCCO.CS(=O)(=O)O.O=Cc1ccc(Cl)nc1>>CS(=O)(=O)OC1CCOC(c2ccc(Cl)nc2)C1,,ClCCl,,,,val
US05900145,C=CCCBr.Oc1ccc(-c2ccc(O)cc2)cc1>>CCC=COc1ccc(-c2ccc(O)cc2)cc1,,CO,,[K+].[OH-],,val
US20150152118A1,CCOC(=O)C1=C(NC(=O)[C@H]2CCC3(C2)OCC(C)(C)CO3)CCC2(CC2)C1>>CCOC(=O)C1=C(NC(=O)[C@H]2CCC(=O)C2)CCC2(CC2)C1,,CCO,,Cl,,val
US20080269196A1,CNC(N)=S.N#Cc1ccc(C(=O)CBr)cc1>>CNc1nc(-c2ccc(C#N)cc2)cs1,,CCO,,O=C([O-])O.[Na+],,val
US20100152157A1,Fc1ccc(-c2nc3ccc(N4CC5CN(Cc6ccccc6)CC5C4)nn3c2-c2ccnnc2)cc1>>Fc1ccc(-c2nc3ccc(N4CC5CNCC5C4)nn3c2-c2ccnnc2)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US06281363B1,CC(C)C[C@@H](C(=O)NN1C(=O)CNC1=O)[C@H](CCCC1CCCCC1)C(=O)NOC1CCCCO1>>CC(C)C[C@@H](C(=O)NN1C(=O)CNC1=O)[C@H](CCCC1CCCCC1)C(=O)NO,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20080194653A1,C=CS(=O)(=O)NCCC1(c2ccccc2)SC(NC(=O)C(C)(C)C)=NN1C(=O)C(C)(C)C.CCN>>CCNCCS(=O)(=O)NCCC1(c2ccccc2)SC(NC(=O)C(C)(C)C)=NN1C(=O)C(C)(C)C,,CC#N,,,,val
US06251911B1,C=Nn1nc(NCCNC(=O)OC(C)(C)C)c(C#N)c1N(C)C.Nc1cccc(Cl)c1>>CC(C)(C)OC(=O)NCCNc1n[nH]c2ncnc(Nc3cccc(Cl)c3)c12,,CO,,Cl,,val
US03941828,CCC#CCC1(Cl)C(=O)CCC(C)C1=O>>CCC#CCC1=C(C)CCC1=O,,Cc1ccccc1C,,O=C([O-])[O-].[Na+].[Na+],,val
US20130217668A1,O=C(O)C1(O)CCC(NCc2ccccc2)CC1>>NC1CCC(O)(C(=O)O)CC1,[Pd],CCO,,,,val
US20030166628A1,CC(Br)C(=O)c1cc2c(F)cccc2s1.S=C1NCCN1>>Br.CC1=C(c2cc3c(F)cccc3s2)N2CCN=C2S1,,CCO,,CC(=O)O,,val
US20040082542A1,CCN(CC)CCCOc1ccc(C(=O)CBr)cc1.CCOC(C)=O.CCc1cc(Oc2ccc([N+](=O)[O-])cc2)ccc1Cl.CN(C)C=O>>CCCCc1nc(-c2ccc(OCCCN(CC)CC)cc2)cn1-c1ccc(Oc2ccc(Cl)c(CC)c2)cc1,,CCOC(C)=O,O,,,val
US20080039457A1,C[C@H](N)C(N)=O.O=C(O)c1ccc(-c2cnc3nnc(C4(c5ccc6ncccc6c5)CC4)n3n2)cc1>>C[C@H](NC(=O)c1ccc(-c2cnc3nnc(C4(c5ccc6ncccc6c5)CC4)n3n2)cc1)C(N)=O,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US04604390,Br.CCN(CC)CCn1nc2c3c(c(N)ccc31)Sc1c(OC)cccc1-2.NCCBr>>Br.CCN(CC)CCn1nc2c3c(c(NCCN)ccc31)Sc1c(OC)cccc1-2,,CCO,,,,val
US08680091B2,CC(C)(C)OC(=O)Nc1ccc(CN)cc1.O=C(N1CCc2ccc(Cl)c(OS(=O)(=O)C(F)(F)F)c2CC1)C(F)(F)F>>CC(C)(C)OC(=O)Nc1ccc(CNc2c(Cl)ccc3c2CCN(C(=O)C(F)(F)F)CC3)cc1,,C1COCCO1,Cc1ccccc1,,,val
US20150307452A1,CO.Cl.NC1(CC(=O)O)CCOC1>>COC(=O)CC1(N)CCOC1.Cl,,CO,,C1COCCO1,Cl,val
US05280047,CCCCCCCCc1ccc(C=O)cc1.CCOC(=O)CC(=O)OCC>>CCCCCCCCc1ccc(C=C(C(=O)OCC)C(=O)OCC)cc1,C1CCNCC1,,,,,val
US20060270637A1,CC(=O)NC[C@H]1CN(c2ccc(B3OC(C)(C)C(C)(C)O3)c(F)c2)C(=O)O1.OC[C@H]1CC(c2ccc(Br)cn2)=NO1>>CC(=O)NC[C@H]1CN(c2ccc(-c3ccc(C4=NO[C@@H](CO)C4)nc3)c(F)c2)C(=O)O1,c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd-4]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04185016,COC1Nc2c(ccc(C)c2O)C(=O)N2CCCC12>>Cc1ccc2c(c1O)N=CC1CCCN1C2=O,,CC#N,,,,val
US20030096793A1,C=CCC[Si](C)(C(=O)CC(C)C)c1ccccc1>>C=CCC[Si](C)(c1ccccc1)C(O)CC(C)C,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040204397A1,CCOC(=O)c1ccc2[nH]ccc2c1.C[Si](C)(C)CCS(=O)(=O)Cl>>CCOC(=O)c1ccc2c(ccn2S(=O)(=O)CC[Si](C)(C)C)c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20050277676A1,Cc1csc(-c2ccc(F)cc2NC(=O)OCC2CCN(C(=O)OC(C)(C)C)CC2)n1>>Cc1csc(-c2ccc(F)cc2NC(=O)OCC2CCNCC2)n1,,C1COCCO1,ClCCl,Cl,,val
US20050256102A1,Cc1ccccc1C(=O)c1cc(Cl)ccc1NC(=O)c1ccccc1.O=C1CCC(=O)N1Br>>O=C(Nc1ccc(Cl)cc1C(=O)c1ccccc1CBr)c1ccccc1,,ClC(Cl)(Cl)Cl,ClCCl,,,val
US20160200707A1,C/C=C/C=C/CO.O=C1CCC(=O)O1>>C/C=C/C=C/COC(=O)CCC(=O)O,,CCOCC,,CCN(C(C)C)C(C)C,,val
US20050256201A1,CC1(C)OCc2cc([C@@H]3CN(CCc4ccc(OCCO)cc4)C(=O)O3)ccc2O1.CS(=O)(=O)Cl>>CC1(C)OCc2cc([C@@H]3CN(CCc4ccc(OCCOS(C)(=O)=O)cc4)C(=O)O3)ccc2O1,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US05665718,CCCBr.CCN(C(C)C)C(C)C.CN(C)C=O.NCc1nnc(-c2ncn3c2[C@@H]2CCN2C(=O)c2sccc2-3)o1>>CCCN(CCC)Cc1nnc(-c2ncn3c2[C@@H]2CCN2C(=O)c2sccc2-3)o1,,CN(C)C=O,,,,val
US20130338159A1,CSc1nccc(-c2cnc(N)nc2CC2CC2)n1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nccc(-c2cnc(N)nc2CC2CC2)n1,,ClCCl,O,,,val
US05502187,CN.Clc1cc(Cl)nc(Cl)n1>>CNc1cc(Cl)nc(Cl)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US05556864,CN(C)CCCl.Oc1ccccc1CCCCc1ccccc1>>CN(C)CCOc1ccccc1CCCCc1ccccc1,,CC(=O)N(C)C,,Cl,[H-].[Na+],val
US20110046169A1,CC(C)(C)OC(=O)Nc1ccc(O)c(F)c1.O=[N+]([O-])c1ccc(Cl)nc1>>CC(C)(C)OC(=O)Nc1ccc(Oc2ccc([N+](=O)[O-])cn2)c(F)c1,,CS(C)=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20060194788A1,CCOC(=O)CCCCBr.CCOC(=O)CNCc1ccccc1>>CCOC(=O)CN(CCCCC(=O)O)Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080207703A1,CN(CCNC(=O)OC(C)(C)C)Cc1csc(NC(=O)NCc2ccc(Cl)c(Cl)c2)n1.Cl>>CN(CCN)Cc1csc(NC(=O)NCc2ccc(Cl)c(Cl)c2)n1.Cl,,C1COCCO1,,,,val
US20100069407A1,CNC.ClCCl.N#CN=C([S-])[S-]>>CSC(=NC#N)N(C)C,,C1CCOC1,,,,val
US20040102651A1,CNC=CC(=O)c1ccccc1>>CNCCC(O)c1ccccc1,,CC(=O)O,,[Na+].[OH-],,val
US20110028455A1,CN1CCNCC1.Cc1ncc(C#N)c(Nc2ccc3[nH]ccc3c2C)c1-c1ccc(C=O)o1>>Cc1ncc(C#N)c(Nc2ccc3[nH]ccc3c2C)c1-c1ccc(CN2CCN(C)CC2)o1,CC(=O)O,CN1CCCC1=O,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100016279A1,OCCOC1CCCCO1.Oc1cccc(C2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)c1>>OCCOc1cccc(C2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100016401A1,COC(=O)c1cccc2c1C=CCO2>>O=C(O)c1cccc2c1C=CCO2,,CO,O,[Na+].[OH-],,val
US20060241115A1,Cl.Cn1cc(NC(=O)OC(C)(C)C)ccc1=O>>Cl.Cn1cc(N)ccc1=O,,C1COCCO1,,,,val
US04059431,COP(=O)(CCO)OC.O=S(=O)(Cl)CCCBr>>COP(=O)(CCOS(=O)(=O)CCCBr)OC,,CCOCC,,c1ccncc1,,val
US03931180,CCN(CC)c1nc(O)cc(O)n1.COS(=O)(=O)OC>>CCN(CC)c1nc(O)cc(OC)n1,,[Na+],[OH-],,,val
US20090042967A1,CC[C@H](N)C(=O)O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC[C@@H]1NC(=O)OC1=O,,C1CCOC1,,,,val
US20070010670A1,Cc1cccc(O)c1N.O=C(Cl)CCl>>Cc1cccc(O)c1NC(=O)CCl,,C1CCOC1,,CCN(CC)CC,O,val
US20130225673A1,CCc1oc2ccccc2c1C(=O)c1ccc(OC)c(F)c1>>CCc1oc2ccccc2c1C(=O)c1ccc(O)c(F)c1,,CN(C)C=O,,,,val
US20120053350A1,CC(C)(C)OC(=O)[C@@H]1CC[C@H](O)CN1C(=O)OC(C)(C)C.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1>>CC(C)(C)OC(=O)[C@@H]1CC[C@H](OS(=O)(=O)c2ccc(C(F)(F)F)cc2)CN1C(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,O,,val
US20120196869A1,CN1CCn2cccc2C12CCN(C(=O)OCc1ccccc1)CC2.O=C1CCC(=O)N1Br>>CN1CCn2c(Br)ccc2C12CCN(C(=O)OCc1ccccc1)CC2,,ClCCl,,,,val
US20160144052A1,COc1cc2c(cc1OCc1cc(C#CCNC(=O)CCOCCOCCOCCOCCN)cc(COc3cc4c(cc3OC)C(=O)N3C=C(C)C[C@H]3[C@H](O)N4C(=O)OC(C)(C)C)c1)N(C(=O)OC(C)(C)C)[C@@H](O)[C@@H]1CC(C)=CN1C2=O.O=C(CI)OC(=O)CI>>COc1cc2c(cc1OCc1cc(C#CCNC(=O)CCOCCOCCOCCOCCNC(=O)CI)cc(COc3cc4c(cc3OC)C(=O)N3C=C(C)C[C@H]3[C@H](O)N4C(=O)OC(C)(C)C)c1)N(C(=O)OC(C)(C)C)[C@@H](O)[C@@H]1CC(C)=CN1C2=O,,ClCCl,,,,val
US20030013886A1,O=C(O)/C=C/c1c(F)cccc1F.O=S(Cl)Cl>>O=C(Cl)/C=C/c1c(F)cccc1F,,c1ccccc1,,,,val
US05266554,Cc1cc(=O)n(-c2cc(C(=O)O)c(C#N)cc2F)c(=O)n1C.O=S(Cl)Cl>>Cc1cc(=O)n(-c2cc(C(=O)Cl)c(C#N)cc2F)c(=O)n1C,CN(C)C=O,,,,,val
US20070155808A1,CC(C)CCNc1nc(-c2ccc(C(F)(F)F)cc2)cs1.COC(=O)CCc1ccc(OCc2ccc(CCl)cc2)cc1>>COC(=O)CCc1ccc(OCc2ccc(CN(CCC(C)C)c3nc(-c4ccc(C(F)(F)F)cc4)cs3)cc2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US06903101B1,Clc1nnc(Cc2ccncc2)c2ccccc12.Nc1ccc(Oc2ccncc2)cc1>>c1ccc2c(Nc3ccc(Oc4ccncc4)cc3)nnc(Cc3ccncc3)c2c1,,CCCCO,,,,val
US06506747B1,Cc1cccc(C)c1C=O.N#Cc1cc(-c2cccnc2)nn1-c1ccc(N)cc1>>Cc1cccc(C)c1CNc1ccc(-n2nc(-c3cccnc3)cc2C#N)cc1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20110003815A1,CC(=O)CNC(=O)c1ccc(C2(c3ccc(OCc4ccccn4)cc3)CC3CCC2C3)cc1>>Cc1cnc(-c2ccc(C3(c4ccc(OCc5ccccn5)cc4)CC4CCC3C4)cc2)o1,,O=S(Cl)Cl,,,,val
US20090291971A1,Brc1cnc(On2nnc3cccnc32)nc1.C=Cc1ccc(B(O)O)cc1>>C=Cc1ccc(Oc2ncc(Br)cn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05910506,Cc1cc(C)cc(Sc2c(C(C)C)nc(C)n2C)c1.O=C(OO)c1cccc(Cl)c1>>Cc1cc(C)cc(S(=O)(=O)c2c(C(C)C)nc(C)n2C)c1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20010051642A1,COc1ccc2c(c1CCc1ccccc1)CCCC2=O>>O=C1CCCc2c1ccc(O)c2CCc1ccccc1,,CS(C)=O,,[C-]#N.[Na+],,val
US20090029905A1,Cc1nc(Br)sc1C(=O)N1CCC1.Cn1ccc(NC(=O)c2cc(O)cc(O[C@H]3CCOC3)c2)n1>>Cc1nc(Oc2cc(O[C@H]3CCOC3)cc(C(=O)Nc3ccn(C)n3)c2)sc1C(=O)N1CCC1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070249607A1,CC(C)(C)OC(=O)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccc(F)cc2Br)CC1>>N#Cc1ccc(-c2cc(COCC3(c4ccc(F)cc4Br)CCNCC3)cc(C(F)(F)F)c2)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20150087585A1,OC1(c2cccc(C3OCCO3)n2)COC1>>O=Cc1cccc(C2(O)COC2)n1,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120208791A1,Brc1cnn(C2CCNCC2)c1.CS(=O)(=O)Cl>>CS(=O)(=O)N1CCC(n2cc(Br)cn2)CC1,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20040037022A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=[N+]([O-])c1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1>>CC(C)(C)OC(=O)N(C[C@H](O)COc1ccccc1)[C@H](CO)Cc1ccc([N+](=O)[O-])cc1,,C1CCOC1,,,,val
US20110046132A1,COCCOCn1c(Cl)nc2cc(C(=O)O)ccc21.Nc1ccccc1>>COCCOCn1c(Cl)nc2cc(C(=O)Nc3ccccc3)ccc21,,CC#N,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150119380A1,COCOc1cc(C2(F)CCN(C(=O)OCc3ccccc3)CC2)ccc1C=O>>O=Cc1ccc(C2(F)CCN(C(=O)OCc3ccccc3)CC2)cc1O,,CCO,O,Cl,,val
US20110064662A1,CB1OB(C)OB(C)O1.CC[C@H](C)c1c(C(=O)NC)nc(-c2cc(Br)ccc2Cl)c2ccccc12>>CC[C@H](C)c1c(C(=O)NC)nc(-c2cc(C)ccc2Cl)c2ccccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20080171739A1,CCOC(=O)CCc1ccc(-c2ccccc2F)nc1>>OCCCc1ccc(-c2ccccc2F)nc1,,C1CCOC1,,O,[BH4-].[Li+],val
US20080064699A1,Cc1nc(N)sc1C.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>Cc1nc(NC(=O)C23CC4CC(CC(C4)C2)C3)sc1C,,C1CCOC1,,CCN(CC)CC,Cl,val
US09248117B2,CC(C)(CCS)NC(=O)OCc1ccccc1.COCCOCCOCCOCCBr>>COCCOCCOCCOCCSCCC(C)(C)NC(=O)OCc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05360791,BrC(Br)(Br)Br.O=CCC1CCCCC1>>BrC(Br)=CCC1CCCCC1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060074075A1,COC(=O)Oc1cc([N+](=O)[O-])c(F)cc1C(C)(C)C>>CC(C)(C)c1cc(F)c([N+](=O)[O-])cc1O,,ClCCl,,C1CCNCC1,,val
US20120083501A1,CC(C)(C)[Si](C)(C)Cl.CC1(CCCO)CC(=O)c2cc(Br)ccc2O1>>CC1(CCCO[Si](C)(C)C(C)(C)C)CC(=O)c2cc(Br)ccc2O1,,ClCCl,,c1c[nH]cn1,,val
US20100056521A1,CCOC(=O)c1ccc(-n2cc(C#N)c3cc(OC)c(F)cc32)cc1>>N#Cc1cn(-c2ccc(C(=O)O)cc2)c2cc(F)c(O)cc12,,ClCCl,,BrB(Br)Br,O,val
US20040138255A1,O=C(OCc1ccccc1)c1ccc2cc(CO)ccc2c1>>O=Cc1ccc2cc(C(=O)OCc3ccccc3)ccc2c1,O=[Mn]=O,ClCCl,,,,val
US05623073,Cc1cn2c3ccccc3n(C)c2n1.O=C(Cl)C(Cl)(Cl)Cl>>Cc1nc2n(C)c3ccccc3n2c1C(=O)C(Cl)(Cl)Cl,,Cc1ccccc1C,,,,val
US20070049618A1,NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1nccs1>>O=C1CCC(N2C(=O)c3cccc(CNC(=O)c4nccs4)c3C2=O)C(=O)N1,,CC#N,,CCN(CC)CC,Cl,val
US20100292266A1,CC(C)(C)OC(=O)N1CCC(C(=O)c2ncco2)CC1.Cl>>Cl.O=C(c1ncco1)C1CCNCC1,,C1COCCO1,,,,val
US20130317000A1,COc1ncccc1-c1cc(C#N)ccc1OCC12CC3CC(CC(C3)C1)C2.OO>>COc1ncccc1-c1cc(C(N)=O)ccc1OCC12CC3CC(CC(C3)C1)C2,,CS(C)=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20120238564A1,CC(C)N(C(=O)OC(C)(C)C)c1nccn2c(-c3ccnc(S(C)(=O)=O)n3)cnc12.Nc1ccccc1>>CC(C)Nc1nccn2c(-c3ccnc(Nc4ccccc4)n3)cnc12,,CCCCO,,Cl,,val
US20110224137A1,O=C(CBr)Oc1ccccc1.O=[N+]([O-])c1cnc2[nH]ccc2c1>>O=C(Cn1ccc2cc([N+](=O)[O-])cnc21)Oc1ccccc1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20060069132A1,CCn1nc(C(C)(C)C)cc1C(=O)Nc1cc(C(=O)O)ccc1F.CN(C)C=O.ClCCl>>CCNC(=O)c1ccc(F)c(NC(=O)c2cc(C(C)(C)C)nn2CC)c1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20080076745A1,CC(C)(C)OC(=O)NCCC[C@@H](CN)NC(=O)OC(C)(C)C.CC(C)(C)OC(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)CC(=O)O>>CC(C)(C)OC(=O)NCCC[C@@H](CNC(=O)C[C@H](CCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20160115125A1,CCOC(=O)c1cc(S(=O)(=O)N[C@H](C)C(F)(F)F)c(C)n1C.O=C1CCC(=O)N1Cl>>CCOC(=O)c1c(Cl)c(S(=O)(=O)N[C@H](C)C(F)(F)F)c(C)n1C,,CC(=O)O,,,,val
US20160130254A1,NO.O=C1CCCC(n2cncn2)C1>>O/N=C1/CCCC(n2cncn2)C1,,c1ccncc1,,Cl,,val
US20080177095A1,CCCC1CCC(c2cc3c4c(c(F)c(F)c3o2)OCCC4)CC1>>CCCC1CCC(C2Cc3c4c(c(F)c(F)c3O2)OCCC4)CC1,[Pd],C1CCOC1,,,,val
US06387911B1,N#Cc1ncccc1F.OCC(F)(F)F>>N#Cc1ncccc1OCC(F)(F)F,,C1CCOC1,,[H-].[Na+],,val
US20070259888A1,C=CCBr.CC(C)(C)OC(=O)N1CCC(O)CC1>>C=CCOC1CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20030004172A1,COC(=O)c1ccc(Cn2c(=O)c3cc(C(=O)NCc4cccc(OC)c4)sc3n(C)c2=O)cc1C>>Cc1cc(Cn2c(=O)c3cc(C(=O)NCc4cccc(O)c4)sc3n(C)c2=O)ccc1C(=O)O,,Cl,,Br,CC(=O)O,val
US05710297,C1=CCC=C1.C1CCNC1.CC(=O)CCC(C)=O.CO>>CC(CCC(C)=C1C=CC=C1)=C1C=CC=C1,,CO,O,CC(=O)O,,val
US05952185,O=C1NC2CSC(CCCCC(=O)ON3C(=O)CCC3=O)C2N1.[N-]=[N+]=Nc1ccc(C(=O)NCCCCCCN)cc1>>CCCCC(C[NH-])NC(=O)c1ccc(N=[N+]=[N-])cc1.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21,,CN(C)C=O,,CCN(CC)CC,,val
US20030125370A1,CC(C)(C)OC(=O)N1CC[C@H](O)[C@H]1C(=O)NC1CC1>>O=C(NC1CC1)[C@H]1NCC[C@@H]1O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20070258887A1,CN(C)c1ccc(-c2cn3c(n2)sc2cc(F)ccc23)cc1.II>>CN(C)c1ccc(-c2cn3c(n2)sc2cc(I)ccc23)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20080039440A1,CCN1CCN(Cc2ccc(NC(=O)N3CCc4cc(Oc5cc(N=[N+]=[N-])ncn5)ccc43)cc2)CC1>>CCN1CCN(Cc2ccc(NC(=O)N3CCc4cc(Oc5cc(N)ncn5)ccc43)cc2)CC1,[Pd],C1CCOC1,,CO,ClCCl,val
US20030100555A1,CC1(C)O[C@H]2[C@H](O[C@H](CO)[C@@H]3OC(C)(C)O[C@@H]32)O1.Cc1cc(C)c(/C=C2\C(=O)N(C(=O)Cl)c3ccccc32)[nH]1>>Cc1cc(C)c(/C=C2\C(=O)N(C(=O)OCC3O[C@@H]4OC(C)(C)O[C@@H]4[C@H]4OC(C)(C)O[C@@H]34)c3ccccc32)[nH]1,,C1CCOC1,c1ccncc1,,,val
US05281614,CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1>>CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20040087582A1,CCCC(Oc1cccc(-c2noc(C)n2)c1)C(=O)OCC>>CCCC(Oc1cccc(-c2noc(C)n2)c1)C(=O)O,,O,,CO,[Na+].[OH-],val
US20070276000A1,COc1ccc2c(Oc3ccc(C=O)cc3)c(-c3ccccc3)c(C)cc2c1.OO>>COc1ccc2c(Oc3ccc(O)cc3)c(-c3ccccc3)c(C)cc2c1,O=S(=O)(O)O,CCOC(C)=O,CO,O=C([O-])O.[Na+],,val
US20160237075A1,C=CC(=O)Cl.NC(=O)c1ccc(-c2cccc(N)c2)nc1-c1ccc(Oc2ccccc2)cc1>>C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)n2)c1,,ClCCl,,,,val
US20080021053A1,CCOC(=O)/C=C/c1ccc(CN2C(=O)N(c3cccc(C(F)(F)F)c3)C(C)=C(C(=O)OCC)C2c2ccc(C#N)cc2)cc1>>CC1=C(C(=O)O)C(c2ccc(C#N)cc2)N(Cc2ccc(/C=C/C(=O)O)cc2)C(=O)N1c1cccc(C(F)(F)F)c1,,CCO,,Cl,[Na+].[OH-],val
US05556864,COc1cc(CCCCc2ccccc2OCC2CO2)cc(OC)c1.OCCNCCO>>COc1cc(CCCCc2ccccc2OCC(O)CN(CCO)CCO)cc(OC)c1,,C1CCOC1,,,,val
US20050090499A1,Brc1cn2ccnc2c(Br)n1.CC(C)(C)OC(=O)N1CCN(c2ccc(N)cc2)CC1>>CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3nc(Br)cn4ccnc34)cc2)CC1,,CC(=O)N(C)C,O,CC#N,O=C([O-])[O-].[K+].[K+],val
US20080249107A1,COc1cc(CCC(=O)Nc2cccc([N+](=O)[O-])c2)cc(OC)c1OC>>COc1cc(CCC(=O)Nc2cccc(N)c2)cc(OC)c1OC,[Pd],CO,,N#N,,val
US20120053174A1,O=C([O-])C(F)(F)c1ncc(F)cn1>>O=C(O)C(F)(F)c1ncc(F)cn1,,CCOC(C)=O,,Cl,,val
US20100130506A1,CC1(C)OC[C@@H](COc2ccc(CCCC(N)C#N)cc2)O1>>CC1(C)OC[C@@H](COc2ccc(CCCC(N)CN)cc2)O1,[Ni],CO,,N,[H][H],val
US20140206663A1,CC1C(=O)N(COCC[Si](C)(C)C)N=C2COc3cc(C(F)(F)F)c(NC4(C)CN(C(c5ccccc5)c5ccccc5)C4)cc3N21>>CC1C(=O)NN=C2COc3cc(C(F)(F)F)c(NC4(C)CN(C(c5ccccc5)c5ccccc5)C4)cc3N21,,ClCCl,O=C(O)C(F)(F)F,,,val
US05852016,COc1nc2cc(Cl)c(Cl)c(NS(C)(=O)=O)c2nc1OC.N#CCCl>>COc1nc2cc(Cl)c(Cl)c(N(CC#N)S(C)(=O)=O)c2nc1OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US07297693B2,CC(C)=O.CON=C1CCc2cc(-c3sc(C(=O)N(C)C4CCN(C)CC4)cc3-c3ccncc3)ccc21>>CN1CCC(N(C)C(=O)c2cc(-c3ccncc3)c(-c3ccc4c(c3)CCC4=O)s2)CC1,,Cl,,C1COCCO1,,val
US20130096120A1,CI.OCCOCCOCCOC12CC3CC(CC(Cn4cccn4)(C3)C1)C2>>Cc1ccnn1CC12CC3CC(C1)CC(OCCOCCOCCO)(C3)C2,,C1CCOC1,,[Li]CCCC,,val
US20140228343A1,CC(C)(C)OC(=O)N1CCC(n2cnc3ccc(Br)cc32)C1>>Brc1ccc2ncn(C3CCNC3)c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150018547A1,COC(=O)Cc1coc2c(C(C)=O)c(OCc3ccc(Cl)cc3Cl)ccc12>>COC(=O)Cc1coc2c(C(C)O)c(OCc3ccc(Cl)cc3Cl)ccc12,,CO,,[BH4-].[Na+],,val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2ccc(O[C@H]3CCCCC[C@@H]3c3ccnn3C)c(F)c2F)c(OC)c1>>Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1ccc(S(=O)(=O)Nc2ccncn2)c(F)c1F,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20030130270A1,CC(C)(S)[C@@H](N)C(=O)O.CC(C)I>>CC(C)SC(C)(C)[C@H](N)C(=O)O,,CCO,,Cl,[H-].[Na+],val
US20160083379A1,CC(C)c1ccc(Nc2ccc(OCc3ccccc3)cc2)cc1.CCI>>CCN(c1ccc(OCc2ccccc2)cc1)c1ccc(C(C)C)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20160108056A1,CC(C)(c1cc(O)cc(OC(F)(F)F)c1)c1cc(Cl)cc([N+](=O)[O-])c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(c1cc(OC(F)(F)F)cc(OS(=O)(=O)C(F)(F)F)c1)c1cc(Cl)cc([N+](=O)[O-])c1,,ClCCl,,c1ccncc1,,val
US20150087672A1,Cc1ccc(S(=O)(=O)N=c2ccc(I)cn2C(C)C(=O)C2CC2)cc1>>Cc1c(C2CC2)nc2ccc(I)cn12,,C1CCOC1,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US04245098,N#CC(Cl)CC(Cl)(Cl)C=O>>Clc1cnc(Cl)c(Cl)c1,,CN(C)C=O,,Cl,,val
US20090082358A1,CCOC(=O)N1C=Cc2ncccc2C1c1ccc(C(F)(F)F)cc1>>CCOC(=O)N1CCc2ncccc2C1c1ccc(C(F)(F)F)cc1,[Pd],CCO,,,,val
US20110312903A1,COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)[C@H](Cc1ccc(S(=O)(=O)C(F)(F)F)cc1)NC(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20130018035A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.O=[N+]([O-])c1c[nH]c2ncc(Br)nc12>>O=[N+]([O-])c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c2ncc(Br)nc12,,CN(C)C=O,,O,[H-].[Na+],val
US20110009454A1,N#Cc1ccc(F)cc1.Oc1ccc2ccccc2c1>>N#Cc1ccc(Oc2ccc3ccccc3c2)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20050277611A1,BrCCOC1CCCCO1.CCCCCCCCCCCCCCOC[C@@H](CO)OCCCCCCCCCCCCCC>>CCCCCCCCCCCCCCOCC(COCCOC1CCCCO1)OCCCCCCCCCCCCCC,,C1CCOC1,C1CCOC1,[H-].[Na+],,val
US20030162690A1,COc1ccc(NC(=O)c2ccc(C#N)cc2)c(C(=O)Nc2ccc(Cl)cn2)c1.NO>>COc1ccc(NC(=O)c2ccc(C(N)=NO)cc2)c(C(=O)Nc2ccc(Cl)cn2)c1,,CCO,,CCN(CC)CC,Cl,val
US20120220552A1,c1ccc(CN2CCOC(c3ccc(N=C(c4ccccc4)c4ccccc4)cc3)C2)cc1>>Nc1ccc(C2CN(Cc3ccccc3)CCO2)cc1,,C1CCOC1,,Cl,,val
US20130116243A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)-c3n[nH]cc3CC4)cc2)CCC1>>NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)-c3n[nH]cc3CC4)cc2)CCC1,,O=C(O)C(F)(F)F,,,,val
US20080242665A1,Cc1c(CN2CCN(C(=O)OC(C)(C)C)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3C(F)(F)F)nc12>>Cc1c(CN2CCNCC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3C(F)(F)F)nc12,,C1COCCO1,Cl,,,val
US04125518,CC(N)(CO)CO.O=C1CCCCC1>>CC1(CO)COC2(CCCCC2)N1,,Cc1ccccc1,,,,val
US20100292184A1,C[C@]12CCC(=O)C=C1C=C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1[C@@H]1C[C@@H]1[C@@H]2C#N.C[Mg]Br>>C[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H]([C@@H]4C[C@@H]4[C@@H]3C#N)[C@@H]21,Cl[Cu],C1CCOC1,O,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20120238545A1,CC(Br)C(=O)O.COc1ccccc1S>>COc1ccccc1SCCC(=O)O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150175599A1,COC(=O)c1cc2c(OC)cccc2[nH]1>>COc1cccc2[nH]c(C)cc12,,C1CCOC1,C1COCCO1,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20150266916A1,C[Mg]Br.O=C[C@@]12CO[C@@](c3ccc(Cl)c(Cc4ccc(OC(F)(F)F)cc4)c3)(O1)[C@H](OCc1ccccc1)[C@@H](OCc1ccccc1)[C@@H]2OCc1ccccc1>>CC(O)[C@@]12CO[C@@](c3ccc(Cl)c(Cc4ccc(OC(F)(F)F)cc4)c3)(O1)[C@H](OCc1ccccc1)[C@@H](OCc1ccccc1)[C@@H]2OCc1ccccc1,,C1CCOC1,,,,val
US20130053382A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC1CC=C(c2cc(F)ccc2N)CC1>>CC(C)(C)OC(=O)NCC1CC=C(c2cc(F)ccc2N)CC1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,,,val
US06090813,CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.O=C1CCC(=O)N1O>>CC(C)(C)OC(=O)N1CCC(C(=O)ON2C(=O)CCC2=O)CC1,,CN(C)C=O,,CCN=C=NCCCN(C)C,,val
US20110251190A1,OCc1cc(-c2cccnc2F)ccc1F>>O=Cc1cc(-c2cccnc2F)ccc1F,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20150225367A1,CC(C)(C)OC(=O)N1CCNCC1.O=S(=O)(Cl)c1ccc(Br)cn1>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(Br)cn2)CC1,,ClCCl,,CCN(CC)CC,,val
US20150225449A1,CC(=O)N1c2ccccc2N(Cc2nn(-c3ccccc3C#N)c3ccccc23)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)[C@@H]1C>>CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2nn(-c3ccccc3C#N)c3ccccc23)c2ccccc2N(C(C)=O)[C@H]1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070219210A1,CCOC(=O)C1=NN(c2cccnc2)C(O)(c2ccc(NC(=O)OC(C)(C)C)cn2)C1>>CCOC(=O)c1cc(-c2ccc(N)cn2)n(-c2cccnc2)n1,,CCO,,Cl,,val
US05665748,CC(C)Oc1ccc(C=O)cc1.CCOC(=O)/C=C/CP(=O)(OCC)OCC>>CCOC(=O)/C=C/C=C/c1ccc(OC(C)C)cc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20030130305A1,C=CC(C)O.C=Cc1cc(C(=O)OC)ccc1O>>C=CC(C)Oc1ccc(C(=O)OC)cc1C=O,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040167155A1,CC1c2ccccc2-c2ccccc2N1S(=O)(=O)c1ccc(O)c(C(=O)O)c1.CCI.CCOCC>>CCOC(=O)c1cc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2C)ccc1OCC,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100029650A1,CC(C)(C)OC(=O)N1CCC(C(=O)Nc2ccc(Br)nc2)CC1.CS(=O)(=O)c1ccc(B(O)O)cc1>>CC(C)(C)OC(=O)N1CCC(C(=O)Nc2ccc(-c3ccc(S(C)(=O)=O)cc3)nc2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20060247244A1,CC(C)(C)OC(=O)c1ccc2c(c1)N(C(=O)CCl)CC(=O)N2C1CC1.NC1CCCCC1>>CC(C)(C)OC(=O)c1ccc2c(c1)N(C(=O)CNC1CCCCC1)CC(=O)N2C1CC1,,C1CCOC1,,,,val
US04045556,Cc1c(C(=O)O)[nH]c(=O)[nH]c1=O.NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)c1cc(=O)[nH]c(=O)[nH]1.O.On1nnc2ccccc21>>Cc1c(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(N)=O)[nH]c(=O)[nH]c1=O.O.O.O,,CCN(CC)CC,CN(C)C=O,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05128351,CCCCCCCCCCCCCCOc1ccc(NC(=O)Nc2cccc(CBr)c2)cc1.Cc1cncs1>>CCCCCCCCCCCCCCOc1ccc(NC(=O)Nc2cccc(C[n+]3csc(C)c3)c2)cc1.[Br-],,C1CCOC1,,,,val
US20150166564A1,COCCN1C[C@@H](NC(=O)Nc2c(C)c(C#N)nn2-c2ccccc2)[C@H](c2ccc(F)c(F)c2)C1.O=S(=O)(O)O>>COCCN1C[C@@H](NC(=O)Nc2c(C)c(C(N)=O)nn2-c2ccccc2)[C@H](c2ccc(F)c(F)c2)C1,,O=S(=O)(O)O,,[Na+].[OH-],,val
US20070032478A1,Cc1cc(C(=O)Cl)n(C)n1.Nc1cccc(Cc2ccc3c(c2)NC(=O)C3)c1>>Cc1cc(C(=O)Nc2cccc(Cc3ccc4c(c3)NC(=O)C4)c2)n(C)n1,,C1CCOC1,,,,val
US20030195200A1,C/C(=C\CO)c1ccc(-c2ccccc2)cc1.CCOC(=O)[C@H](Cc1ccc(O)cc1)OCC>>CCOC(=O)[C@H](Cc1ccc(OC/C=C(\C)c2ccc(-c3ccccc3)cc2)cc1)OCC,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05047593,CC(C)(C)c1cc(SCCC=O)cc(C(C)(C)C)c1O.CC(C)[Mg]Cl>>CC(C)C(O)CCSc1ccc(O)c(C(C)(C)C)c1,,C1CCOC1,,Cl,O,val
US20130197014A1,CN(C(=O)OC(C)(C)C)c1cccc([N+](=O)[O-])c1>>CN(C(=O)OC(C)(C)C)c1cccc(N)c1,[Pd],C1CCOC1,CO,,,val
US20150080393A1,Nc1nc(Cl)cc(Cl)n1.O[C@H](c1ccc(Br)cc1)C(F)(F)F>>Nc1nc(Cl)cc(O[C@H](c2ccc(Br)cc2)C(F)(F)F)n1,,C1COCCO1,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20060111347A1,CC(C)(C)N.O=C1CCOc2cc(CBr)c(Cl)cc21>>CC(C)(C)NCc1cc2c(cc1Cl)C(=O)CCO2,,ClCCl,,CCN(CC)CC,,val
US20100041891A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C(Cc1cccc(C(F)(F)F)c1)Nc1c(Br)cccc1Br>>FC(F)(F)c1cccc(CC(=S)Nc2c(Br)cccc2Br)c1,,Cc1ccccc1,,,,val
US20060128787A1,CC(C)(C)O.CCCCCCCCN1CCc2c(C)c(N)c(C)c(NC(=O)C(C)(C)C)c21.O=C=NS(=O)(=O)Cl>>CCCCCCCCN1CCc2c(C)c(NS(=O)(=O)NC(=O)OC(C)(C)C)c(C)c(NC(=O)C(C)(C)C)c21,,ClCCl,,CCN(CC)CC,,val
US09073882B2,CSc1cc(CCN2CCNCC2)ccc1C#N.O=CCc1ccc2c(c1)COC2=O>>CSc1cc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)ccc1C#N,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090275577A1,CCNC(=O)Nc1cn2ccc(-c3cccnc3)cc2n1.Cc1ccc(S(=O)(=O)Cl)cc1>>CCNC(=O)Nc1nc2cc(-c3cccnc3)ccn2c1Cl,,c1ccncc1,,CCN(CC)CC,O,val
US20100009975A1,CCN(CCN1CCSc2ccc(N)cc21)C(=O)OC(C)(C)C.CSC(=N)c1cccs1>>CCN(CCN1CCSc2ccc(NC(=N)c3cccs3)cc21)C(=O)OC(C)(C)C,,CCO,CCOC(C)=O,I,,val
US06462234B2,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O.CCOC(C)=O>>CCOc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc1,,[Na+],[OH-],Cl,,val
US20090275592A1,O=[N+]([O-])c1cnn(-c2ccc3cnccc3c2)c1>>Nc1cnn(-c2ccc3cnccc3c2)c1,[Pd],C1CCOC1,,,,val
US20090192138A1,CC#CCBr.CN(C)C(=O)c1c(N2CCCN(C(=O)OC(C)(C)C)CC2)[nH]c2c(=O)n(C)c(=O)n(C)c12>>CC#CCn1c(N2CCCN(C(=O)OC(C)(C)C)CC2)c(C(=O)N(C)C)c2c1c(=O)n(C)c(=O)n2C,,CN(C)C=O,,[H-].[Na+],,val
US20120316195A1,Cc1cc(B2OC(C)(C)C(C)(C)O2)ccc1C#N.O=Cc1ccncc1Br>>Cc1cc(-c2cnccc2C=O)ccc1C#N,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20120258987A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4Nc4cccc(-c5ccccc5C)n4)cc3)cc2)CC1>>Cc1ccccc1-c1cccc(Nc2c(C)noc2-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)n1,,CO,,Cl,[Li+].[OH-],val
US04266069,CCOC(=O)C(C)(C(=O)OCC)c1ccc([N+](=O)[O-])c(F)c1>>CCOC(=O)C(C)c1ccc([N+](=O)[O-])c(F)c1,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20040063720A1,COc1cc(N)nc(OC)n1.N#Cc1cnc(Cl)s1>>COc1cc(Nc2ncc(C#N)s2)nc(OC)n1,,C1CCOC1,,[H-].[Na+],,val
US04923857,C=CCOC(=O)N=C1CC[C@@H](C=O)N1C.CC(=O)C(C)=P(c1ccccc1)(c1ccccc1)c1ccccc1>>C=CCOC(=O)N=C1CC[C@@H](C=C(C)C(C)=O)N1C,,Cc1ccccc1,,,,val
US20110021522A1,COc1cccc2cc(C(=O)O)c(=O)oc12.N#Cc1cc(-c2cccc(N)c2)ccc1F>>COc1cccc2cc(C(=O)Nc3cccc(-c4ccc(F)c(C#N)c4)c3)c(=O)oc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05317024,O=C(c1ccccc1)N1CCC(CCOC/C=C/c2ccccc2)CC1>>C(=C/c1ccccc1)\COCCC1CCNCC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05486525,CCOC(=O)c1ccc(CO)o1.CS(=O)(=O)Cl>>CCOC(=O)c1ccc(COS(C)(=O)=O)o1,,ClCCl,,Cc1cccc(C)n1,,val
US05977105,COc1ccc(-c2ccccc2)cc1F>>Oc1ccc(-c2ccccc2)cc1F,,ClCCl,,BrB(Br)Br,,val
US20140350032A1,CC(C)C1=C2[C@H]3CC[C@H]4[C@@](C)(CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(=O)OC(C)(C)C)CC[C@@]54C)[C@]3(C)CC[C@@]2(/C=C/C(=O)Nc2ccc(Cl)cn2)CC1=O.O=C(O)C(F)(F)F>>CC(C)C1=C2[C@H]3CC[C@H]4[C@@](C)(CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(=O)O)CC[C@@]54C)[C@]3(C)CC[C@@]2(/C=C/C(=O)Nc2ccc(Cl)cn2)CC1=O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20050261350A1,CC(=O)Nc1ccc2c(c1)C(C(C)C)C(=O)N2C.O=[N+]([O-])O>>CC(=O)Nc1cc2c(cc1[N+](=O)[O-])N(C)C(=O)C2C(C)C,,CC(=O)O,,,,val
US20130123231A1,C1CO1.CCc1ccccc1Br>>CCc1ccccc1CCO,,C1CCOC1,C1CCOC1,N#N,,val
US20100022513A1,COC(=O)C(C)(C)NC(=O)Oc1ccc([N+](=O)[O-])cc1.c1ccc([C@H]2CCNC2)cc1>>COC(=O)C(C)(C)NC(=O)N1CC[C@H](c2ccccc2)C1,,C1COCCO1,ClCCl,Cl,,val
US20150011528A1,CCOC(=O)C(C)Br.CCOc1ccc2nc(NC(=O)c3cccc(Cl)c3)sc2c1>>CCOC(=O)C(C)n1c(=NC(=O)c2cccc(Cl)c2)sc2cc(OCC)ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120142647A1,CCCNc1nc(NCCC)nc(NOC)n1.Cl>>CCCNc1nc(NCCC)nc(NOC)n1.Cl,,C1COCCO1,,CCOCC,,val
US20070213300A1,Cc1ccc(C(=O)N(C(=O)OCOP(=O)(OCc2ccccc2)OCc2ccccc2)C2CC2)cc1[N+](=O)[O-]>>Cc1ccc(C(=O)N(C(=O)OCOP(=O)(OCc2ccccc2)OCc2ccccc2)C2CC2)cc1N,[Zn],C1CCOC1,CO,[Cl-].[NH4+],,val
US20090062360A1,COCCOc1ccc(C(N)C(N)=O)cc1.O=C1CCCCC1>>COCCOc1ccc(C2NC3(CCCCC3)NC2=O)cc1,,CO,,,,val
US20050282858A1,CCC(C)(C)C1(O)CCNC1.O=C(O)C1(c2ccc(Cl)cc2)CC1>>CCC(C)(C)C1(O)CCN(C(=O)C2(c3ccc(Cl)cc3)CC2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20090149475A1,CC(C)(C)OC(=O)NCCNc1nc[nH]c1C(N)=O.O=C(N=C=S)c1ccccc1.O=C(O)C(F)(F)F>>NCCn1c(=S)[nH]c(=O)c2[nH]cnc21.O=C(O)C(F)(F)F,,CO,ClCCl,,,val
US04748272,CCCCCC(O)c1cccc(O)c1.CCOC(=O)C(Br)c1ccc(OC)cc1>>CCCCCC(O)c1cccc(OC(C(=O)OCC)c2ccc(OC)cc2)c1,,CN(C)C=O,O,[I-].[K+],,val
US03976635,CCOC(=O)C(=NO)C(=O)OCC.CCOC(=O)Cl>>CCOC(=O)ON=C(C(=O)OCC)C(=O)OCC,,CC(C)=O,,O,O=C([O-])O.[Na+],val
US20040087570A1,CC1(C)OC(=O)CC(=O)O1.COC1=NCCC1>>CC1(C)OC(=O)C(=C2CCCN2)C(=O)O1,,c1ccccc1,,CCN(CC)CC,,val
US05840732,CC=C1OC(=O)N(CCCCSc2cccc3nccn23)C1=O.Cl>>CC=C1OC(=O)N(CCCCSc2cccc3nccn23)C1=O.Cl,,CO,,,,val
US20100292255A1,Brc1cc2c(cc1Br)OCCO2.N#C[Cu]>>N#Cc1cc2c(cc1Br)OCCO2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04931083,CCOC(=O)C(C)Br.Oc1ncn(-c2cccc(F)c2)n1>>CCOC(=O)C(C)Oc1ncn(-c2cccc(F)c2)n1,,CCO,CS(C)=O,[Na],,val
US20060178418A1,COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2c1oc1ccc([N+](=O)[O-])cc12>>COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2c1oc1ccc(N)cc12,[Ni],CO,,NN,O,val
US20130066124A1,CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C(C)(C)CCC1>>CC(C)=CCC/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C=C(\C)CCC=C(C)C,,O,,CCOC(C)=O,,val
US06043242,CN(CCO)c1ccnc(CSc2nc3ccccc3[nH]2)c1Cl.O=[N+]([O-])c1cnc2ccc(Cl)nn12>>CN(CCOc1ccc2ncc([N+](=O)[O-])n2n1)c1ccnc(CSc2nc3ccccc3[nH]2)c1Cl.Cl,,C1CCOC1,CN(C)C=O,O,[H-].[Na+],val
US20130237525A1,COS(=O)(=O)OC.Cc1noc2c(C=O)c(O)ccc12>>COc1ccc2c(C)noc2c1C=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06147115,CCC(C)S(N)(=O)=O.O=C=Nc1ccc(F)cc1>>CCC(C)S(=O)(=O)NC(=O)Nc1ccc(F)cc1,,CO,,Cl,C[O-].[Na+],val
US20130190307A1,COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1[N+](=O)[O-]>>COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1N,[Ni],CO,,,,val
US20040171634A1,CI.C[Si](C)(C)CCOCOc1ccc(Br)c(CCO)c1>>COCCc1cc(OCOCC[Si](C)(C)C)ccc1Br,,CS(C)=O,O,[K+].[OH-],,val
US20160002205A1,CI.Oc1cc(Br)cnc1Cl>>COc1cc(Br)cnc1Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080221361A1,COCCCN.O=C(O)CO>>COCCC[NH3+].O=C([O-])CO,,CCO,,,,val
US06359143B1,CCOC(=O)C(CCC(=O)[O-])C(C)=O>>CCOC(=O)C1=C(C)OC(=O)CC1,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US06022906,CCC(Cc1ccccc1)(C(=O)c1ccc(-c2ccc(Br)cc2)cc1)N(C)C.SCCCS>>CCC(Cc1ccccc1)(C(=O)c1ccc(-c2ccc(SCCCS)cc2)cc1)N(C)C,,CN(C)C=O,,O,[H-].[Na+],val
US04415562,CC(C)(C)OC(=O)C1(ON=C(C(=O)O)c2csc(NC(c3ccccc3)(c3ccccc3)c3ccccc3)n2)CCC1.Cc1ccc(S(=O)(=O)OC=CC2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)C(N)C3S(=O)C2)cc1>>Cc1ccc(S(=O)(=O)OC=CC2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)C(NC(=O)C(=NOC4(C(=O)OC(C)(C)C)CCC4)c4csc(NC(c5ccccc5)(c5ccccc5)c5ccccc5)n4)C3S(=O)C2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20010039344A1,Nc1nccs1.O=C(O)C(CC1CCCC1)c1cccc(C(F)(F)F)c1>>O=C(Nc1nccs1)C(CC1CCCC1)c1cccc(C(F)(F)F)c1,CN(C)C=O,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20010014684A1,COCCOCN(c1onc(C)c1Cl)S(=O)(=O)c1c(Cc2ccc(C)cc2C)sc2ncccc12>>Cc1ccc(Cc2sc3ncccc3c2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1,,CO,,Cl,,val
US20100240688A1,O=C1CCC(=O)N1Br.O=c1cc(OCc2ccccc2)ccn1CC1CC1>>O=c1c(Br)c(OCc2ccccc2)ccn1CC1CC1,,ClCCl,,,,val
US20050059687A1,CO.COc1ccc(S(=O)(=O)N2CCN(C(C)c3nc(Cl)c4ccccc4n3)CC2)cc1>>COc1ccc(S(=O)(=O)N2CCN(C(C)c3nc(OC)c4ccccc4n3)CC2)cc1,,C1CCOC1,,,,val
US20060229337A1,Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(C=O)cc2)n1.OCCNCCO>>Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(CN(CCO)CCO)cc2)n1,,CO,,CC(=O)O,[BH4-].[Na+],val
US20050107423A1,O=C(OC1C(F)CC2CN(C(=O)OCc3ccccc3)CC21)c1ccccc1>>O=C(OCc1ccccc1)N1CC2CC(F)C(O)C2C1,,CO,,CC(=O)O,C[O-].[Na+],val
US05288693,CCOC(OCC)OCC.O=CCCn1sc(Cl)cc1=O>>CCOC(CCn1sc(Cl)cc1=O)OCC,,CCO,,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US20070072925A1,BrCc1cccc(Br)c1.OCCF>>FCCOCc1cccc(Br)c1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20090258855A1,Clc1ccnc2ccc(Br)cc12.OCCO>>OCCOc1ccnc2ccc(Br)cc12,,CN(C)C=O,,[H-].[Na+],,val
US20160046648A1,CC(C)(C)c1ccccc1-c1ccncc1>>CC(C)(C)c1ccccc1C1CCNCC1,O=[Pt]=O,CO,Cl,,,val
US20150353570A1,Nc1nccn2c([C@@H]3CC[C@H]4CN(C(=O)OCc5ccccc5)CC(=O)N4C3)nc(Br)c12>>Nc1nccn2c([C@@H]3CC[C@H]4CNCC(=O)N4C3)nc(Br)c12,,Br,CC(=O)O,CC(C)O,,val
US20160009710A1,N#CBr.NNc1cc(COc2ccc(Cl)c(Cl)c2)c(Br)cn1>>Nc1nnc2cc(COc3ccc(Cl)c(Cl)c3)c(Br)cn12,,CC(C)O,,ClCCl,,val
US05661159,Cc1ccccc1S(=O)(=O)NC(=O)c1ccc2oc(-c3ccc4ccccc4n3)cc2c1.Cl>>Cc1ccccc1S(=O)(=O)NC(=O)c1ccc2oc(-c3ccc4ccccc4n3)cc2c1.Cl,,CCOC(C)=O,,,,val
US04582529,C#CCN.O=Cc1ccccc1>>C#CCN=Cc1ccccc1,,c1ccccc1,,O=S(=O)([O-])[O-].[Mg+2],,val
US20050070542A1,CCc1nc2c(nc1-c1ccc(C(C)C)nc1O)c(C)nn2C(CC)CC.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCc1nc2c(nc1-c1ccc(C(C)C)nc1OS(=O)(=O)C(F)(F)F)c(C)nn2C(CC)CC,,ClCCl,,CCN(CC)CC,,val
US20040248872A1,CC(CCOS(C)(=O)=O)=C(F)F.Cc1nc(Nc2ccccc2)sc1C(=O)O>>CC(CCOC(=O)c1sc(Nc2ccccc2)nc1C)=C(F)F,,O,,CN(C)C=O,O=C([O-])O.[Na+],val
US20040235822A1,CCOc1ccnc(CSc2ccc([N+](=O)[O-])cc2C)c1>>CCOc1ccnc(CSc2ccc(N)cc2C)c1,,CC(=O)O,,,,val
US20100069381A1,NNC(=O)c1ccc2[nH]ncc2c1.S=C=S>>Sc1nnc(-c2ccc3[nH]ncc3c2)o1,,CCO,O,CCN(CC)CC,Cl,val
US20150353537A1,C[C@@H]1COC[C@@H](C)N1C[C@H]1CN(C(=O)OC(C)(C)C)[C@H](C)CN1Cc1ccccc1>>C[C@@H]1COC[C@@H](C)N1C[C@H]1CN(C(=O)OC(C)(C)C)[C@H](C)CN1,[Pd],CCO,,CC(=O)O,,val
US20060030609A1,COC(=O)[C@H]1CN(c2ccc3c(c2)CC(=O)N3CCF)C(=O)O1.N>>NC(=O)[C@H]1CN(c2ccc3c(c2)CC(=O)N3CCF)C(=O)O1,,CO,,,,val
US20100069431A1,Nc1cccnc1N.O=C(O)c1cccc(NS(=O)(=O)c2cccs2)c1>>O=S(=O)(Nc1cccc(-c2nc3ncccc3[nH]2)c1)c1cccs1,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US04987132,CCCCN=C=O.c1ccc(CN2CCNCC2)cc1>>CCCCNC(=O)N1CCN(Cc2ccccc2)CC1,,C1CCOC1,,,,val
US20100113796A1,BrBr.CC(C)Oc1ccc(-c2nc(-c3ccc4[nH]ccc4c3)no2)cc1Cl>>CC(C)Oc1ccc(-c2nc(-c3ccc4[nH]cc(Br)c4c3)no2)cc1Cl,,CN(C)C=O,,,,val
US20110319439A1,Clc1cc(Cl)ncn1.OB(O)/C=C/c1ccc(Cl)cc1>>Clc1ccc(/C=C/c2cc(Cl)ncn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20070167413A1,FC(F)(F)c1ccc(N2CCNCC2)nc1.NS(=O)(=O)c1cccc(-c2nc(C(F)(F)F)nc(Cl)c2-c2ccccc2)c1>>NS(=O)(=O)c1cccc(-c2nc(C(F)(F)F)nc(N3CCN(c4ccc(C(F)(F)F)cn4)CC3)c2-c2ccccc2)c1,,c1ccncc1,,Cl,,val
US05290801,CCCCCCCN(CCCCCBr)C(=O)Nc1ccc(F)cc1F.S=C1N=C2CCCCC2=N1>>CCCCCCCN(CCCCCSc1nc2c([nH]1)CCCC2)C(=O)Nc1ccc(F)cc1F,,CN(C)C=O,,O,[H-].[Na+],val
US20040157836A1,COC(=O)c1c(NS(=O)(=O)c2ccccc2[N+](=O)[O-])ccc2c1CCCC2>>COC(=O)c1c(NS(=O)(=O)c2ccccc2N)ccc2c1CCCC2,[Ni],CCOC(C)=O,,CO,,val
US20130231328A1,CC(C)(C)OC(=O)N1CCC(COc2ncnc3sc4c(c23)[C@@H](CC#N)CC4)CC1.OO>>NC(=O)C[C@H]1CCc2sc3ncnc(OCC4CCNCC4)c3c21,,CCOC(C)=O,CO,O,[Li]O,val
US20020049223A1,O=C1Cc2ccsc2C1>>OC1Cc2ccsc2C1,,C1CCOC1,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20150232435A1,CC(C)(C)c1nc(N2CCN(CCCCN)CC2)c2ccccc2n1.O=C(n1ccnc1)n1ccnc1.c1ccc(N2CCNCC2)cc1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCN(c4ccccc4)CC3)CC2)c2ccccc2n1,,CO,ClC(Cl)Cl,,,val
US20050256103A1,CC(C)=CC(=O)O.Oc1cc(O)cc(O)c1>>CC1(C)CC(=O)c2c(O)cc(O)cc2O1,,CS(=O)(=O)O,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US05654318,CC(C)(C)OC(=O)N1CCCC2CN(Cc3ccccc3)CC21>>CC(C)(C)OC(=O)N1CCCC2CNCC21,[Pd],CCO,,,,val
US20110092547A1,CCOC(=O)C1(C)CCC(Oc2ccc([N+](=O)[O-])cn2)CC1>>CCOC(=O)C1(C)CCC(Oc2ccc(N)cn2)CC1,[Pd],CCO,,,,val
US20050245519A1,CC(C)(C)OC(=O)N1CCO[C@H](COc2ccccc2OCc2ccccc2)C1>>CC(C)(C)OC(=O)N1CCO[C@H](COc2ccccc2O)C1,[Pd],CCO,,,,val
US04218458,CCN1C[NH+](Cc2ccccc2)C=C1c1ccc(O)cc1.[Br-]>>Br.CCn1cncc1-c1ccc(O)cc1,[Pd],CCO,,[H][H],,val
US20130317033A1,C[Si](C)(C)Cl.Clc1ccc(Cl)nn1>>C[Si](C)(C)c1cc(Cl)nnc1Cl,,C1CCOC1,,CC1(C)CCCC(C)(C)N1,[Li]CCCC,val
US20100324049A1,CC(=O)Nc1cncc(C2CCN(Cc3ccc(/C(=N/O)c4ccc(F)c(F)c4)nc3)CC2)c1.CCCBr>>CCCO/N=C(\c1ccc(F)c(F)c1)c1ccc(CN2CCC(c3cncc(NC(C)=O)c3)CC2)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20120094997A1,COC(=O)c1ccc2ccn(CCBr)c(=O)c2c1.COc1ccc(O)cc1>>COC(=O)c1ccc2ccn(CCOc3ccc(OC)cc3)c(=O)c2c1,,C1CCOC1,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US20090233903A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc(B(O)O)c1.C[Si](C)(C)CCOCn1ccc2c(Cl)ncnc21>>C[Si](C)(C)CCOCn1ccc2c(-c3cc[nH]c3)ncnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20030092677A1,CC(C)(C)OC(=O)Nc1ccc(-c2ccc(Cl)c(Cl)c2)cc1[N+](=O)[O-]>>CC(C)(C)OC(=O)Nc1ccc(-c2ccc(Cl)c(Cl)c2)cc1N,[Ni],,,,,val
US04734419,NCc1ccc(Br)cc1F.O=C(Cl)c1ccc(Br)cc1[N+](=O)[O-]>>O=C(NCc1ccc(Br)cc1F)c1ccc(Br)cc1[N+](=O)[O-],,ClC(Cl)Cl,,CCN(CC)CC,,val
US20060030583A1,COCCN.Nc1ncc(Br)cc1C(=O)c1ccc(F)nc1>>COCCNc1ccc(C(=O)c2cc(Br)cnc2N)cn1,,CCO,O,CCN(CC)CC,,val
US20060173018A1,CCCOC(=O)Cl.Cc1ccc2c(N3CC[C@@H](CN)C3)nc(-c3ccccc3O)nc2c1>>CCCOC(=O)NC[C@@H]1CCN(c2nc(-c3ccccc3O)nc3cc(C)ccc23)C1,,ClCCl,,CCN(CC)CC,,val
US20110166116A1,CC(C)OC(=O)N1CCC(ON=C2CCN(c3cc(F)c(C4SCCCS4)cc3F)CC2)CC1.O=C(OO)c1cccc(Cl)c1>>CC(C)OC(=O)N1CCC(ON=C2CCN(c3cc(F)c(C4SCCCS4=O)cc3F)CC2)CC1,,ClCCl,,,,val
US20070213336A1,CC(C)(C)OC(=O)Nc1cccc(Br)c1.CI>>CN(C(=O)OC(C)(C)C)c1cccc(Br)c1,,CN(C)C=O,,[H-].[Na+],,val
US20070185088A1,CC(C)(C)[O-].N#Cc1cccc(Br)c1.NO>>Cc1nc(-c2cccc(Br)c2)no1,,CO,,Cl,,val
US20050086747A1,CNCCO.COc1ccc([N+](=O)[O-])c(Cl)n1>>COc1ccc([N+](=O)[O-])c(CNCCO)n1,,O,,C1COCCO1,,val
US20060135572A1,CC(Cl)OC(=O)OC1CCCCC1.CC(OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1ccccc1-c1ccc(C(=O)O)cc1>>CC(OC(=O)OC1CCCCC1)OC(=O)c1ccc(-c2ccccc2C(C)OC[C@H](O)CNC(C)(C)Cc2ccc3ccccc3c2)cc1,,CN(C)C=O,O,[I-].[K+],,val
US20120142668A1,CC[C@@H](/C=C/C(=O)N1CCc2ccccc21)NC(=O)[C@@H]1CCCCN1C(=O)OC(C)(C)C.O=S(=O)(O)O>>CC[C@@H](/C=C/C(=O)N1CCc2ccccc21)NC(=O)[C@@H]1CCCCN1.O=S(=O)(O)O,,C1COCCO1,,,,val
US20100305070A1,BrP(Br)Br.OCc1cc2cc(F)ccc2o1>>Fc1ccc2oc(CBr)cc2c1,,Cc1ccccc1,,,,val
US20110039840A1,COC(=O)/C=C/c1ccc2c(c1)C(=O)NC1(CCN(CCc3ccccc3)CC1)O2>>O=C(O)/C=C/c1ccc2c(c1)C(=O)NC1(CCN(CCc3ccccc3)CC1)O2,,C1COCCO1,O,Cl,[Na+].[OH-],val
US04874775,CS(=O)(=O)OS(C)(=O)=O.Cc1ccc(NCc2cccnc2)c(Cl)c1>>Cc1ccc(N(Cc2cccnc2)S(C)(=O)=O)c(Cl)c1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20050101650A1,CO.CS(=O)(=O)Cl.O=Cc1c[nH]c(C(=O)C(Cl)(Cl)Cl)c1>>COC(=O)c1cc(C=O)cn1S(C)(=O)=O,,CCN(CC)CC,,Cl,[H-].[Na+],val
US20050234101A1,Brc1ccc(I)nc1.CC(C)(C)OC(=O)NCCN>>CC(C)(C)OC(=O)NCCNc1ccc(Br)cn1,,CCOC(C)=O,,,,val
US20040102500A1,CCCN.COc1ccc(CCC(=O)O)cc1>>CCCNC(=O)CCc1ccc(OC)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,Cl,val
US20020077318A1,CC(C)(C)OC(=O)N1CCc2[nH]c3ccccc3c2CC1.NC(=O)CI>>CC(C)(C)OC(=O)N1CCc2c(n(CC(N)=O)c3ccccc23)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20110190303A1,BrC1CCCC1.Cc1cc2c(C=O)ccc(O)c2o1>>Cc1cc2c(C=O)ccc(OC3CCCC3)c2o1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20140179666A1,CC(C)(C)OC(=O)N1CC(C)(C)c2ncc(Br)cc21.CCCC(=O)N(C)OC>>CCCC(=O)c1cnc2c(c1)N(C(=O)OC(C)(C)C)CC2(C)C,,CCOCC,,[Li]CCCC,,val
US20100267666A1,CC(C)(C)C(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3cccc(C=O)c3)nc12.c1nnc2n1CCNC2>>CC(C)(C)C(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3cccc(CN4CCn5cnnc5C4)c3)nc12,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130116234A1,Br[Mg]c1ccccc1.COc1ccc(C#N)c(N)c1.[OH-]>>COc1ccc(C(=O)c2ccccc2)c(N)c1,,CCOCC,,Cl,,val
US03951640,CNc1nnc(SC)s1.O=C(Cl)Cl>>CSc1nnc(N(C)C(=O)Cl)s1,,c1ccccc1,,,,val
US20150210687A1,COC(=O)c1cc(F)c(-c2nn(Cc3c(C)cccc3Cl)c3cccc(F)c23)cc1OC>>Cc1cccc(Cl)c1Cn1nc(-c2cc(O)c(C(=O)O)cc2F)c2c(F)cccc21,,ClCCl,,BrB(Br)Br,,val
US20110130380A1,CC1(C)COC(CNc2nc(F)ccc2F)CO1.OCc1ccccc1>>CC1(C)COC(CNc2nc(OCc3ccccc3)ccc2F)CO1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20040116460A1,COc1cc(N)cc(OC)c1OC.O=C(Br)CBr>>COc1cc(NC(=O)CBr)cc(OC)c1OC,,C1CCOC1,,CCN(CC)CC,,val
US20070072862A1,COC(=O)c1cc(C(=O)NCCC2CCCC2)ccc1C>>Cc1ccc(C(=O)NCCC2CCCC2)cc1C(=O)O,,C1CCOC1,O,[Li+].[OH-],,val
US20100173909A1,C=CCO[C@H]1CN(C(=O)OCC)CC[C@H]1NC(=O)OC(C)(C)C>>C=CCO[C@H]1CN(C(=O)OCC)CC[C@H]1N,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20130035311A1,CC1(C)OB(c2ccc(CBr)cc2)OC1(C)C.O=C(CO)c1ccccc1>>CC(=O)c1ccccc1OCc1ccc(B2OC(C)(C)C(C)(C)O2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090324581A1,O=C(O)c1ccc(C2CCCCC2)cc1C(F)(F)F>>OCc1ccc(C2CCCCC2)cc1C(F)(F)F,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20030008849A1,CC#CCOc1ccc(S(=O)(=O)NC2(C(=O)NO)CCN(C(=O)OC(C)(C)C)CC2)cc1>>CC#CCOc1ccc(S(=O)(=O)NC2(C(=O)NO)CCNCC2)cc1,,C1COCCO1,,Cl,,val
US20140274701A1,BrBr.COC(=O)c1nc(-c2ccc([Si](C)(C)C)c3c2OC(F)(F)O3)c(F)c(N)c1Cl>>COC(=O)c1nc(-c2ccc(Br)c3c2OC(F)(F)O3)c(F)c(N)c1Cl,,ClCCCl,,O=S([O-])O.[Na+],,val
US04510158,CO.O=C(O)C1CC=C(c2c(-c3ccccc3)[nH]c3ccccc23)CC1>>COC(=O)C1CC=C(c2c(-c3ccccc3)[nH]c3ccccc23)CC1,,ClCCl,,CS(=O)(=O)O,,val
US20130059846A1,Cc1ccc(C(N)=NO)cc1NC(=O)c1cnc2ccccn12.O=C1CC2(C1)CC(C(=O)O)C2>>Cc1ccc(-c2noc(C3CC4(CC(=O)C4)C3)n2)cc1NC(=O)c1cnc2ccccn12,,CN1CCCC1=O,,O=C(n1ccnc1)n1ccnc1,,val
US20120088766A1,CC(C)(C)OC(=O)N1CCC(N)CC1.Nc1nc2ccc(-c3cccc(C(=O)Nc4cccc(C(F)(F)F)c4)c3)nc2s1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.O=C(O)C(F)(F)F>>O=C(Nc1nc2ccc(-c3cccc(C(=O)Nc4cccc(C(F)(F)F)c4)c3)nc2s1)NC1CCNCC1.O=C(O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20130184257A1,CS(=O)(=O)c1cc(F)c(N[C@H]2CCCCN(C3CCN(C#N)CC3)C2=O)cc1F.NO>>CS(=O)(=O)c1cc(F)c(N[C@H]2CCCCN(C3CCN(C(N)=NO)CC3)C2=O)cc1F,,CCO,,,,val
US06048868,CCOC(=O)NC(=O)CC#N.COc1ccc2[nH]cc(CCN)c2c1>>COc1ccc2[nH]c3c(c2c1)CCN1C(=O)NC(=O)CC31,[Pd],CC(=O)O,,,,val
US04963590,O=[N+]([O-])c1cc(CO)cc(O)c1O.c1cc[nH]c1>>O=[N+]([O-])c1cc(Cc2ccc[nH]2)cc(O)c1O,,C1COCCO1,,O,,val
US20130116243A1,CCOC(=O)NN=C1COc2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc2N1>>CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)-n3c(n[nH]c3=O)CO4)cc2)CCC1,,CN(C)C=O,ClCCl,,,val
US04738986,NOCc1ccccc1.O=C=Nc1ccccc1.O=CCOc1ccc2ccccc2c1>>O=C(Nc1ccccc1)N(O)CCOc1ccc2ccccc2c1,,Cc1ccccc1,,CCO,O,val
US20140235612A1,O=[N+]([O-])c1cccnc1Nc1ccc(Cl)cc1>>Nc1cccnc1Nc1ccc(Cl)cc1,[Ni],CCOC(C)=O,,,,val
US03993646,CC1(CBr)S[C@@H]2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)OCC(Cl)(Cl)Cl>>CC1=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(NC(=O)Cc3ccccc3)[C@H]2SC1,,c1ccncc1,,ClC(Cl)Cl,,val
US20100105900A1,CI.CN(C)C[C@@H](CC(=O)OCc1ccccc1)NS(=O)(=O)c1ccc(Oc2ccccc2)nc1>>C[N+](C)(C)C[C@@H](CC(=O)OCc1ccccc1)NS(=O)(=O)c1ccc(Oc2ccccc2)nc1.[I-],,ClCCl,,,,val
US20150087639A1,O=[N+]([O-])c1ccc(F)c(F)c1.OCCN1CCOCC1>>O=[N+]([O-])c1ccc(OCCN2CCOCC2)c(F)c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150018335A1,Cc1cccc(-c2ccc(CN3CCN(C(=O)OC(C)(C)C)CC3)c(C)c2)c1>>Cc1cccc(-c2ccc(CN3CCNCC3)c(C)c2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120214822A1,C1CCOC1.CCN(CC)CC.COC(=O)c1ccc(C)c(-n2cc(Br)nc(Br)c2=O)c1.ClCCN1CCCC1.NCCc1ccc(O)cc1>>Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(NCCc2ccc(OCCN3CCCC3)cc2)c1=O,,C1CCOC1,CN(C)C=O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20150210688A1,COC(=O)c1ccc(C)c(-c2nc(C)[nH]c2Cl)c1>>Cc1nc(-c2cc(C(=O)O)ccc2C)c(Cl)[nH]1,,CO,,[Na+].[OH-],,val
US05276154,CON(C)C(C)=O.O=Cc1c(C2CC2)nc2ccccc2c1-c1ccc(F)cc1>>CON(C)C(=O)CC(O)c1c(C2CC2)nc2ccccc2c1-c1ccc(F)cc1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20050085639A1,CCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCO)c1Oc1ccccc1OC.COc1cnc(Cl)nc1>>CCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(OC)cn2)c1Oc1ccccc1OC,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20030055071A1,COc1ccc(C)[n+]([O-])c1Br.O=[N+]([O-])O>>COc1c([N+](=O)[O-])cc(C)[n+]([O-])c1Br,,O=S(=O)(O)O,,[Na+].[OH-],,val
US20150284327A1,CN(C(=O)CCl)c1ccc([N+](=O)[O-])cc1.CN1CCNCC1>>CN1CCN(CC(=O)N(C)c2ccc([N+](=O)[O-])cc2)CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060084643A1,CI.Cc1cc2c(s1)Nc1cc(F)ccc1NC2=S>>CSC1=Nc2ccc(F)cc2Nc2sc(C)cc21,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070185103A1,CN(C)C=O.COc1ccc2c(c1)C(NC[C@@H](O)[C@@H](N)Cc1ccccc1)CC(C)(C)C2=O.O=C(O)c1cc(-c2ccccn2)c(=O)n(C2CCCC2)c1>>COc1ccc2c(c1)[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc(N3CCCC3=O)c(=O)n(C3CCCC3)c1)CC(C)(C)C2=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110152282A1,Cc1ccc(N)cc1-c1cc2ccccc2cn1.Clc1ncnc2c1CCN(Cc1ccccc1)C2>>Cc1ccc(Nc2ncnc3c2CCN(Cc2ccccc2)C3)cc1-c1cc2ccccc2cn1,,CC(C)O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US07629358B2,COC(=O)c1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(CO)c2)c1>>C[C@H](Cc1cccc(C(=O)O)c1)NC[C@H](O)c1ccc(O)c(CO)c1,,C1CCOC1,,Cl,[Li+].[OH-],val
US05306692,CCOC(=O)C(C)n1ncc2ccc([N+](=O)[O-])cc21>>CCOC(=O)C(C)n1ncc2ccc(N)cc21,,CC(C)O,,Cl,O,val
US20140005226A1,COC(CBr)OC.Oc1ccc(F)cc1>>COC(COc1ccc(F)cc1)OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150133674A1,CCO.COC(CN)OC.O=C=NS(=O)(=O)Cl>>CCOC(=O)NS(=O)(=O)NCC(OC)OC,,ClCCl,,CCN(CC)CC,Cl,val
US20070049610A1,CC(=O)Cl.COc1ccc2c(c1)C(C)CCC2>>COc1cc2c(cc1C(C)=O)CCCC2C,,ClCCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US04097481,CN(Cc1ccccn1)C(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F>>CN(CC1CCCCN1)C(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F,[Pt],CC(=O)O,,,,val
US20040209928A1,CC(C)(C)NC1CCCCC1.CCOC(=O)C(C)NC(=O)c1ccc(C(Br)CO[Si](C)(C)C(C)(C)C)cc1>>CCOC(=O)CCNC(=O)c1ccc(C(CO[Si](C)(C)C(C)(C)C)NC2CCC(C(C)(C)C)CC2)cc1,,CS(C)=O,O,CCOC(C)=O,,val
US20090163533A1,CCCn1nc(C#N)c(Br)c1CC1(F)CCN(C(=O)OC(C)(C)C)CC1.Cl>>CCCn1nc(C#N)c(Br)c1CC1(F)CCNCC1.Cl,,CCO,,,,val
US20090253671A1,COC(=O)c1cccc(NC(=O)[C@H](CO)NC(=O)OCc2ccccc2)c1>>COC(=O)c1cccc(N2CC(NC(=O)OCc3ccccc3)C2=O)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070225308A1,CI.CNc1ncc2c(-c3cccc(Cl)c3)c(/C=C/C(=O)O)cc(OC)c2n1>>CNc1ncc2c(-c3cccc(Cl)c3)c(/C=C/C(=O)OC)cc(OC)c2n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070066610A1,O=C(NCCCO)c1cc(Br)c2cc[nH]c2c1.OC[C@@H]1CCCN1>>O=C(NCCCN1CCC[C@H]1CO)c1cc(Br)c2cc[nH]c2c1,,C1CCOC1,C1CCOC1,CCN(CC)CC,CS(=O)(=O)Cl,val
US20020198388A1,CC(C)(C)N.CC(C)C=O>>CC(C)C=NC(C)(C)C,,CCOCC,,O=S(=O)([O-])[O-].[Mg+2],,val
US04073799,COC(=O)CC(=O)CCC=C(C)C.Cc1ccc(S(=O)(=O)N=[N+]=[N-])cc1>>COC(=O)C(=[N+]=[N-])C(=O)CCC=C(C)C,,CCN(CC)CC,,,,val
US20090306078A1,COC(=O)c1cncc(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1>>O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cncc(C(=O)O)c1,,c1ccncc1,,[I-].[Li+],,val
US20080299080A1,CI.COC(=O)c1sc(C#CC(C)(C)C)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)[C@@H]1CC[C@@H](O)CC1>>COC(=O)c1sc(C#CC(C)(C)C)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)[C@@H]1CC[C@@H](OC)CC1,,CN(C)C=O,,[H-].[Na+],,val
US05242912,BrCc1ccccc1.O=C(O)c1cc(Br)cc2c1NCCCC2>>O=C(OCc1ccccc1)c1cc(Br)cc2c1NCCCC2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05357001,CC1CCC(C(C)C)C(N)C1.CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)O>>CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)NC1(C)CCC(C(C)C)CC1,,C1CCOC1,,CCN(CC)CC,CCOC(=O)Cl,val
US05436359,CI.COc1c(O)c(CCCCCCCCCCO)c(C)c(OC(=O)c2cccnc2)c1OC>>COc1c(O)c(CCCCCCCCCCO)c(C)c(OC(=O)C2=CN(C)C=CC2)c1OC,,CN(C)C=O,,,,val
US20130053409A1,COc1cc(N2CC[C@@H]3CN(C)C[C@@H]32)c([N+](=O)[O-])cc1Nc1nccc(-c2cnn3ccccc23)n1>>COc1cc(N2CC[C@@H]3CN(C)C[C@@H]32)c(N)cc1Nc1nccc(-c2cnn3ccccc23)n1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20120258949A1,BrC1CCCC1.COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCCN(C(=O)OC(C)(C)C)C1)O2>>COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCCN(C3CCCC3)C1)O2,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120165305A1,CC(C)(C)OC(=O)N1CCN(c2ccc(-c3cnn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CC1>>O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(N5CCNCC5)nc4)cnn23)c1,,C1COCCO1,CO,Cl,,val
US20100144707A1,CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CC[C@H](N(C)C)C4)c(OC)cc3n2)c1>>CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CC[C@H](N(C)C)C4)c(OC)cc3n2)c1,,Cl,,,,val
US20140275173A1,O=CCC12CCC(c3ccccc3Oc3ccccc3)(CC1)OC2>>OCCC12CCC(c3ccccc3Oc3ccccc3)(CC1)OC2,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20060161001A1,CC(=O)O.c1ccc(-c2cc3c(cn2)CCCN3c2ccnc(NC3CCNCC3)n2)cc1>>CC(=O)N1CCC(Nc2nccc(N3CCCc4cnc(-c5ccccc5)cc43)n2)CC1,,ClCCl,,,,val
US07427616B2,CN.OC1COC(O)CO1.[C-]#[N+]C(c1ccccc1)S(=O)(=O)c1ccc(C)cc1>>Cn1cnc(-c2ccccc2)c1CO,,C1CCOC1,,,,val
US06034275,BrCCCCCCBr.CSc1cc(O)ccc1C(=O)c1ccc(Br)cc1>>CSc1cc(OCCCCCCBr)ccc1C(=O)c1ccc(Br)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080242692A1,COc1ccc(C=NCC(OC)OC)cc1OC>>COc1ccc(CNCC(OC)OC)cc1OC,,CCO,O,[BH4-].[Na+],,val
US20030119826A1,CS(=O)(=O)Cl.Cc1noc(=O)n1CC=CCCO>>Cc1noc(=O)n1CC=CCCOS(C)(=O)=O,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20090286778A1,COc1ccc([N+](=O)[O-])c(I)c1>>COc1ccc(N)c(I)c1,[Fe],CO,O,CC(=O)O,,val
US20070191293A1,NS(=O)(=O)OC[C@H]1C=C[C@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)C1>>NS(=O)(=O)OC[C@H]1CC[C@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)C1,[Pd],CCOC(C)=O,,,,val
US20070259888A1,COCCO[C@@H]1CCCN(C[C@@H]2CCCC[C@H]2NC(=O)OC(C)(C)C)C1.Cl>>COCCO[C@@H]1CCCN(C[C@@H]2CCCC[C@H]2N)C1.Cl,,C1COCCO1,,,,val
US20070197537A1,N#C[Cu].Nc1ccc(Oc2ccnc3cc(I)sc23)c(F)c1>>N#Cc1cc2nccc(Oc3ccc(N)cc3F)c2s1,,CN(C)C=O,,[C-]#N.[Na+],,val
US20090318517A1,CC(=O)OC(C)=O.O=C(NCc1cc(Cl)ccc1-n1cnnn1)[C@@H]1CC=NN1C(=O)[C@H](O)c1ccc(F)cc1>>CC(=O)O[C@@H](C(=O)N1N=CC[C@H]1C(=O)NCc1cc(Cl)ccc1-n1cnnn1)c1ccc(F)cc1,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20040209901A1,CCN=C=O.Cc1cc(F)ccc1-c1nc(NCCN)nc2c1ccc(=O)n2-c1c(F)cccc1F>>CCNC(=O)NCCNc1nc(-c2ccc(F)cc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1,,C1CCOC1,ClCCl,,,val
US20130225524A1,COC(=O)c1cc(N2CCN(C)CC2)cc([N+](=O)[O-])c1>>CN1CCN(c2cc(N)cc(C(=O)O)c2)CC1,[Pd],CO,,[Na+].[OH-],,val
US20050282864A1,C1COCCN1.O=C(O)c1cc2cc(O)ccc2[nH]1>>O=C(c1cc2cc(O)ccc2[nH]1)N1CCOCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20080188529A1,CC(=O)N[C@@H](CC(C)C(F)(F)F)C(=O)O>>CC(C[C@H](N)C(=O)O)C(F)(F)F,,O,,[Na+].[OH-],,val
US20150232483A1,Fc1cnc(N2CC3CONC3(c3cccnc3)C2)nc1.O=C(N=C=S)c1ccccc1>>O=C(NC(=S)N1OCC2CN(c3ncc(F)cn3)CC21c1cccnc1)c1ccccc1,,C1CCOC1,,,,val
US05589478,CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(-c2ccc(C)cc2)c(OCCO)n1.Clc1ncc(Br)cn1>>CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(-c2ccc(C)cc2)c(OCCOc2ncc(Br)cn2)n1,,C1CCOC1,CC(=O)N(C)C,[H-].[Na+],,val
US20100035987A1,CC(C)(C)OC(=O)NC1CC=CCC1.COCCBr>>COCCN(C(=O)OC(C)(C)C)C1CC=CCC1,,C1CCCCC1,CCOC(C)=O,,,val
US20060167248A1,CC(C)(C)OC(=O)NCC(O)c1ccc(F)cc1.ClCCl>>Fc1ccc(C2CNCCO2)cc1,,O=C(O)C(F)(F)F,,,,val
US20040122047A1,COC(=O)C(Cc1ccc2c(c1)CN(C(=O)c1c(Cl)cccc1Cl)CC2)NC(=O)OC(C)(C)C>>COC(=O)C(N)Cc1ccc2c(c1)CN(C(=O)c1c(Cl)cccc1Cl)CC2,,ClCCl,O=C(O)C(F)(F)F,,,val
US20030148470A1,Nc1nc(=O)n([C@H]2CC[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)cc1C#CCOCCOCCNC(=O)C(F)(F)F>>NCCOCCOCC#Cc1cn([C@H]2CC[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)nc1N,,[NH4+],[OH-],,,val
US20050182072A1,CSc1nc(-c2ccnc(NC(C)c3ccccc3)c2)cc(N2CC3CC2CN3C(=O)OC(C)(C)C)n1>>CSc1nc(-c2ccnc(N[C@@H](C)c3ccccc3)c2)cc(N2C[C@@H]3C[C@H]2CN3)n1,,C1COCCO1,ClCCl,CO,Cl,val
US20100105604A1,C=CCCBr.CCOC(=O)c1ccccc1O>>C=CCCOc1ccccc1C(=O)O,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100160255A1,CCN1CCC2(CCCN(C3CCN(C(=O)c4c(NC(=O)OC(C)(C)C)sc5ccccc45)CC3)C2)C1=O>>CCN1CCC2(CCCN(C3CCN(C(=O)c4c(N)sc5ccccc45)CC3)C2)C1=O,,O=C(O)C(F)(F)F,,O=C([O-])O.[Na+],,val
US06242443B1,Nc1ccc(C(=O)O)cc1S(N)(=O)=O.S=C(n1ccnc1)n1ccnc1>>O=C(O)c1ccc2c(c1)S(=O)(=O)N=C(n1ccnc1)N2,,C1COCCO1,,,,val
US20100105655A1,CCN(CC)CC.COc1cc(N2CCCC2C(=O)O)ccc1[N+](=O)[O-].ClCCl>>COc1cc(N2CCCC2C(=O)N2CCOCC2)ccc1[N+](=O)[O-],,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20060111402A1,FC(F)(F)Cc1nc2cc(Cl)c(Cl)cc2[nH]1.O=C(CBr)c1ccccc1>>O=C(Cn1c(CC(F)(F)F)nc2cc(Cl)c(Cl)cc21)c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20070197621A1,CCCCN.O=Cc1c(F)cccc1Cl>>CCCC/N=C/c1c(F)cccc1Cl,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20160060257A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)C1=C(OS(=O)(=O)C(F)(F)F)CN(C(=O)OC(C)(C)C)CC1>>CCOC(=O)C1=C(B2OC(C)(C)C(C)(C)O2)CN(C(=O)OC(C)(C)C)CC1,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20160060258A1,C1COCCN1.O=Cc1cc([N+](=O)[O-])ccc1Cl>>O=Cc1cc([N+](=O)[O-])ccc1N1CCOCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20070196270A1,CC(=O)Nc1cc(Cl)c(F)cc1/C=C/C(=O)O.CN1CC2CN(Cc3ccc(F)cc3)CC(C1)N2>>CC(=O)Nc1cc(Cl)c(F)cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2,,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US04000277,CC(C)CCBr.CCn1ncc2c3[nH]c4ccnn4c(=O)c3cnc21>>CCn1ncc2c1ncc1c(=O)n3nccc3n(CCC(C)C)c12,,COCCOCCOC,,[Na],,val
US20100173929A1,CC(C)(C)OC(=O)N[C@@H](CCN)C(=O)OC(C)(C)C.O=[N+]([O-])c1cc(Br)cnc1Cl>>CC(C)(C)OC(=O)NC(CCNc1ncc(Br)cc1[N+](=O)[O-])C(=O)OC(C)(C)C,,C1COCCO1,,CCN(CC)CC,Cl,val
US20140088101A1,COC(=O)C=CC(C(=O)OC)=C(C)NCc1ccc(C#N)cc1.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Br)c(=O)n(Cc2ccc(C#N)cc2)c1C,,CO,,C[O-].[Na+],,val
US20120238545A1,BrP(Br)Br.CCOC(=O)c1nn(-c2ccccc2)c(Br)c1CO>>CCOC(=O)c1nn(-c2ccccc2)c(Br)c1CBr,,CCOCC,,,,val
US20130131062A1,CC(C)(C)OC(=O)NCCCBr.O=[N+]([O-])c1cccc(O)c1>>CC(C)(C)OC(=O)NCCCOc1cccc([N+](=O)[O-])c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140094459A1,CC(C)(C)OC(=O)N1CCCC(n2nc(I)c3c(N)ncnc32)C1.OB(O)c1ccc(Oc2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20070249670A1,COC(=O)[C@@H](NC(=O)c1ccc(-c2ccc(OC)cc2)cc1N)C(C)(C)C.Cc1cc(C)c(N=C=O)c(C)c1>>COC(=O)[C@@H](NC(=O)c1ccc(-c2ccc(OC)cc2)cc1NC(=O)Nc1c(C)cc(C)cc1C)C(C)(C)C,,c1ccncc1,,CCCCCC,CCOC(C)=O,val
US20120329818A1,CC(C)(C)OC(=O)N1CCC(Cc2ccccc2)(C(=O)O)CC1.CN(C)C(=O)Oc1cccc(N)c1>>CN(C)C(=O)Oc1cccc(NC(=O)C2(Cc3ccccc3)CCN(C(=O)OC(C)(C)C)CC2)c1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20070249723A1,CON(C)C(=O)C(CC(F)(F)F)CC(F)(F)F>>O=CC(CC(F)(F)F)CC(F)(F)F,,ClCCl,,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US20160038504A1,C=C(C)B1OC(C)(C)C(C)(C)O1.Cc1cnnc(Cl)c1>>C=C(C)c1cc(C)cnn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20100073621A1,CCCCC[C@@H]1CC[C@@H](c2ccc(I)cc2)CC1.OB(O)c1cccc(F)c1>>CCCCC[C@@H]1CC[C@@H](c2ccc(-c3cccc(F)c3)cc2)CC1,,Cc1ccccc1,O,O=C([O-])[O-].[K+].[K+],,val
US04076709,CCOC(=O)CI.CNS(=O)(=O)c1ccsc1C(=O)OC>>CCOC(=O)CN(C)S(=O)(=O)c1ccsc1C(=O)OC,,CN(C)C=O,,[H-].[Na+],,val
US20100261679A1,CNC(=O)c1cc(Oc2ccc3nc(S(C)(=O)=O)ncc3c2)ccn1.NCc1cccc2c1OCCO2>>CNC(=O)c1cc(Oc2ccc3nc(NCc4cccc5c4OCCO5)ncc3c2)ccn1,,CN(C)C=O,,Cl,,val
US06579883B1,CC(C)(C)[Si](C)(C)Cl.O=C1Nc2cc(CCO)ccc2C2CCCC12>>CC(C)(C)[Si](C)(C)OCCc1ccc2c(c1)NC(=O)C1CCCC21,,CCOCC,CN(C)C=O,c1c[nH]cn1,,val
US20120046292A1,CCOC(=O)[C@H]1CC[C@@H](Oc2ccc(C(=O)NCCNC(=O)OC(C)(C)C)cc2)CC1.Cl>>CCOC(=O)[C@@H]1CC[C@H](Oc2ccc(C(=O)NCCN)cc2)CC1.Cl,,C1COCCO1,,,,val
US20090029905A1,Cc1cnc(N)cn1.O=C(O)c1cc(Oc2ncc(C(=O)N3CCC3)cc2Cl)cc(OC(CF)CF)c1>>Cc1cnc(NC(=O)c2cc(Oc3ncc(C(=O)N4CCC4)cc3Cl)cc(OC(CF)CF)c2)cn1,,ClCCl,,c1ccncc1,,val
US20160002264A1,C=CCC(O)CC1CC1.CCOC(CBr)OCC>>C=CCC(CC1CC1)OCC(OCC)OCC,,C1CCOC1,,[H-].[Na+],,val
US20040058923A1,CS(=O)(=O)Cl.Nc1cccc(CC(=O)O)c1>>CS(=O)(=O)Nc1cccc(CC(=O)O)c1,,O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20150291655A1,C=C(C)[C@@H]1CC[C@]2(NC(=O)CC3CCOCC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@](CF)(C(=O)OCc7ccccc7)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(NC(=O)CC3CCOCC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@](CF)(C(=O)O)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1COCCO1,CO,[Na+].[OH-],,val
US20080124384A1,CC1CCCN1.Cn1ccnc1N1CCN(c2cc(-c3ccc(F)cc3)nc(Cl)n2)CC1>>CC1CCCN1c1nc(-c2ccc(F)cc2)cc(N2CCN(c3nccn3C)CC2)n1,,CC(=O)N(C)C,,,,val
US20120010183A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(O)c1cc(Cl)c(F)cc1F>>CC(C)(C)OC(=O)c1cc(Cl)c(F)cc1F,CN(C)c1ccncc1,CC(C)(C)O,,,,val
US05807857,C1=COCCC1.NNc1ccc(-n2cnnc2)cc1>>OCCCc1c[nH]c2ccc(-n3cnnc3)cc12,,C1COCCO1,,Cl,,val
US05736534,COc1cc2ncnc(Cl)c2cc1OC.Cc1ccc(Br)c2c1NCC2>>COc1cc2ncnc(N3CCc4c(Br)ccc(C)c43)c2cc1OC,,CN(C)C=O,,,,val
US20100202971A1,CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO[C@H]1O[C@H](CS(=O)(=O)O)[C@@H](OC(=O)CCNC(=O)OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1>>CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO[C@H]1O[C@H](CS(=O)(=O)O)[C@@H](OC(=O)CCN)[C@H](O)[C@H]1O,[Pd],CC(=O)O,CO,,,val
US20070149525A1,N#Cc1cccc(C2C=COCOC2)c1>>N#Cc1cccc(C2CCOCOC2)c1,[Pd],CCOC(C)=O,,,,val
US06388104B1,COC(CCl)OC.OCC(O)CCl>>ClCC1COC(CCl)O1,Cc1ccc(S(=O)(=O)O)cc1,,,,,val
US04994471,CI.COC1(OC)CCN(Cc2ccccc2)CC1O>>COC1CN(Cc2ccccc2)CCC1(OC)OC,,CN(C)C=O,,[H-].[Na+],,val
US20160145245A1,CC(C)(C)OC(=O)N[C@H](C(=O)N1CCCC1)c1ccc(O)cc1.OCCBr>>CC(C)(C)OC(=O)N[C@H](C(=O)N1CCCC1)c1ccc(OCCO)cc1,,CC(C)=O,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20080051418A1,BrCc1ccccc1.COC(=O)c1cc(OC(C)C)n[nH]1>>COC(=O)c1cc(OC(C)C)nn1Cc1ccccc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090156600A1,CCc1nc2c(F)ccc(OCC(=O)OC)c2c(OC(F)F)c1Cc1ccc(C(=O)NC2CCC2)cc1Cl>>CCc1nc2c(F)ccc(OCC(=O)O)c2c(OC(F)F)c1Cc1ccc(C(=O)NC2CCC2)cc1Cl,,C1CCOC1,,[Li+].[OH-],,val
US20130096149A1,CC(C)(C)C(N)=S.CSc1nccc(C(Br)C(=O)c2cc(F)cc(NC(=O)C(C)(C)C)c2Cl)n1>>CSc1nccc(-c2sc(C(C)(C)C)nc2-c2cc(F)cc(NC(=O)C(C)(C)C)c2Cl)n1,,CC(=O)N(C)C,O,,,val
US20100113796A1,CCOC(=O)CCCn1ccc2c(C#N)cccc21.NO>>CCOC(=O)CCCn1ccc2c(C(=N)NO)cccc21,,CCO,,Cl,O=C([O-])O.[Na+],val
US20020058767A1,C1=CC2C3C=CC(C3)C2C1.Cc1ccccc1>>C1=CC2C3C=CC(C3)C2C1.C=C,,Cc1ccccc1,,,,val
US04145546,CI.O=c1[nH]c(=S)[nH]cc1Cc1ccc(Cl)cc1>>CSc1ncc(Cc2ccc(Cl)cc2)c(=O)[nH]1,,CCO,O,[Na+].[OH-],,val
US20030139418A1,CCNCc1ccccc1[N+](=O)[O-]>>CCNCc1ccccc1N,[Pd],CCO,,[H][H],,val
US20090270381A1,N#Cc1ccc(NC(=O)C(O)(C#Cc2ccc(C3OCCO3)cc2)C2CCCCC2)cc1Cl>>N#Cc1ccc(NC(=O)C(O)(C#Cc2ccc(C=O)cc2)C2CCCCC2)cc1Cl,,CO,,Cl,O=C([O-])O.[Na+],val
US20080249138A1,CCOC(=O)c1cccc(Cc2cc(Cl)ccc2O)n1.Fc1cc(Cl)ccc1CBr>>CCOC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110183938A1,O=C1CCO1.OC1CCNCC1>>OC1CCN(C2COC2)CC1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100267697A1,CC(C)(C)OC(=O)OC(C)(C)C.Nc1ccc(F)cc1>>CC(C)(C)OC(=O)Nc1ccc(F)cc1,,Cc1ccccc1,,,,val
US06630495B1,C=CCBr.FC(F)(F)c1cnc(CNC(=S)c2ccccc2Cl)c(Cl)c1>>C=CCSC(=NCc1ncc(C(F)(F)F)cc1Cl)c1ccccc1Cl,,C1CCOC1,,[H-].[Na+],,val
US20090036450A1,Cc1ccc(-c2nc(C)c(CO)s2)s1.ClC(Cl)Cl.O=S(Cl)Cl>>Cc1ccc(-c2nc(C)c(CCl)s2)s1.Cl,,ClC(Cl)Cl,,,,val
US05185333,CC(C)(C)C(=O)Cl.CCN1CC(C)(C)Oc2c(C(=O)O)cc(Cl)cc21.NC1CN2CCC1CC2>>CCN1CC(C)(C)Oc2c(C(=O)NC3CN4CCC3CC4)cc(Cl)cc21.Cl,,CCOC(C)=O,,CCN(CC)CC,,val
US20100137371A1,COC(=O)C[C@](O)(c1cnc(Sc2ccc3c(-c4ccc(F)cc4)cc(=O)oc3c2)s1)C(F)(F)F>>O=c1cc(-c2ccc(F)cc2)c2ccc(Sc3ncc([C@@](O)(CCO)C(F)(F)F)s3)cc2o1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050009843A1,CC(C)(C)OC(=O)/C=C/c1c(N2CCC(OC(=O)NCCO)CC2)nc2cc(C(=O)Nc3nc(C(C)(C)C)cs3)ccn2c1=O>>CC(C)(C)c1csc(NC(=O)c2ccn3c(=O)c(/C=C/C(=O)O)c(N4CCC(OC(=O)NCCO)CC4)nc3c2)n1,,C1COCCO1,Cl,,,val
US20020040043A1,Cc1ccc(S(=O)(=O)OCCc2ccc(C#N)cc2)cc1.Nc1ccccc1S>>N#Cc1ccc(CCSc2ccccc2N)cc1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20040157886A1,Nc1ccc2c(c1)OCC(=O)N2.O=C(O)C(=O)N1CCC(Cc2ccc(F)cc2)CC1>>O=C1COc2cc(NC(=O)C(=O)N3CCC(Cc4ccc(F)cc4)CC3)ccc2N1,,CCOCC,,,,val
US07566784B2,CCOC(=O)Nc1nccc2[nH]ccc12.NC(=O)CCC(=O)NI>>CCOC(=O)Nc1nccc2[nH]cc(I)c12,,C1CCOC1,,,,val
US05250574,CC(C)(C)OCl.Oc1ccc(Oc2cc(F)cc(F)c2)cc1>>Oc1ccc(Oc2cc(F)cc(F)c2)cc1Cl,,ClC(Cl)(Cl)Cl,,,,val
US20120223634A1,COC=Cc1c(C)cccc1C>>Cc1cccc(C)c1CC=O,,C1COCCO1,,Cl,O,val
US04876271,OCc1cc2sccc2s1>>O=Cc1cc2sccc2s1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20060172973A1,COC(=O)C(O)=CC(=O)c1cn(Cc2ccccc2)c(=O)n(Cc2ccccc2)c1=O>>O=C(O)C(O)=CC(=O)c1cn(Cc2ccccc2)c(=O)n(Cc2ccccc2)c1=O,,C1COCCO1,,Cl,,val
US04965273,Br.Br.c1ccc(CN2C[C@H]3C[C@@H]2CN3)cc1>>Br.Br.CCCCCCC,[Pd],O,,,,val
US20030195203A1,Cc1cc(-c2ccc(C(=O)O)cc2)ccn1.O=S(=O)(c1ccc2cc(Br)ccc2c1)N1CCNCC1>>Cc1cc(-c2ccc(C(=O)N3CCN(S(=O)(=O)c4ccc5cc(Br)ccc5c4)CC3)cc2)ccn1,,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20150051203A1,CCc1n[nH]c2cc(OCc3ccccc3)c(C(=O)O)cc12.c1ccc(NN2CCOCC2)cc1>>CCc1n[nH]c2cc(OCc3ccccc3)c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc12,CN(C)C=O,ClCCl,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20090209536A1,[N-]=[N+]=NCc1nc(N2CCCC2)c2ccccc2n1>>NCc1nc(N2CCCC2)c2ccccc2n1,[Pd],CO,,[H][H],,val
US06599917B1,CC(C)(C)[Si](C)(C)Cl.O=C(c1ccccc1)c1nc(CO)ccc1OCc1ccccc1>>CC(C)(C)[Si](C)(C)OCc1ccc(OCc2ccccc2)c(C(=O)c2ccccc2)n1,,CN(C)C=O,,c1c[nH]cn1,,val
US20130065906A1,COc1ccc(-c2noc(Cl)n2)cc1.O=C(c1ccc(-c2cnco2)cc1)N(C1CCNCC1)C1CC1>>COc1ccc(-c2noc(N3CCC(N(C(=O)c4ccc(-c5cnco5)cc4)C4CC4)CC3)n2)cc1,,CN1CCCC1=O,,,,val
US20110288067A1,CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Oc3ccc4c(c3)[C@H](N)CC4)nc12.CS(=O)(=O)Cl>>CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Oc3ccc4c(c3)[C@H](NS(C)(=O)=O)CC4)nc12,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20110294758A1,COC(=O)c1cc(Oc2ccc(P(=O)(OC(C)C)OC(C)C)cc2)cc(Sc2nccn2C)c1>>CC(C)OP(=O)(OC(C)C)c1ccc(Oc2cc(Sc3nccn3C)cc(C(=O)O)c2)cc1,,O,,C1COCCO1,[Na+].[OH-],val
US20030216283A1,CC(C)CCOCC1CO1.O=S(=O)(O)O>>CC(C)CCOC(O)C(C)O,,CC(C)=O,,,,val
US20120202785A1,CC(NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2n1-c1ccncc1>>CC(N)c1nc2ccc(F)cc2n1-c1ccncc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US06197967B1,CC1(C)OB(c2ccc(C(=O)NN)cc2)OC1(C)C.CCOC(OCC)OCC>>CC1(C)OB(c2ccc(-c3nnco3)cc2)OC1(C)C,,CCO,,,,val
US04474787,CCCc1c(NC(C)=O)ccc2c(=O)cc(C(=O)OCC)oc12>>CCCc1c(N)ccc2c(=O)cc(C(=O)OCC)oc12,,CCO,O,Cl,,val
US20100298295A1,CNC(=O)c1ccc(-c2cc(C)c([N+](=O)[O-])cc2C(C)C)cc1>>CNC(=O)c1ccc(-c2cc(C)c(N)cc2C(C)C)cc1,[Pd],CO,,,,val
US20040214841A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Oc1cc(OC2CCNCC2)c2c(Nc3c(Cl)ccc4c3OCO4)ncnc2c1>>CC(C)(C)OC(=O)N1CCC(Oc2cc(O)cc3ncnc(Nc4c(Cl)ccc5c4OCO5)c23)CC1,,CN(C)C=O,,,,val
US20110009382A1,COC(=O)c1cccc2nc(CN(C)S(=O)(=O)c3c(C)cc(OC)cc3C)[nH]c12>>COc1cc(C)c(S(=O)(=O)N(C)Cc2nc3cccc(CO)c3[nH]2)c(C)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150111885A1,Cn1ccc2c(c1=O)NC(=O)CO2.O=C1CCC(=O)N1Br>>Cn1cc(Br)c2c(c1=O)NC(=O)CO2,,CC#N,,CCOC(C)=O,,val
US20090281092A1,C=C[C@@]1(F)CN(C2CCCC2)c2nc(Nc3cc(F)c(C(=O)OC)cc3OC)ncc2N(C)C1=O>>C=C[C@@]1(F)CN(C2CCCC2)c2nc(Nc3cc(F)c(C(=O)O)cc3OC)ncc2N(C)C1=O,,Cl,,,,val
US20090030015A1,COC(=O)Cc1ccc(-c2cccc(NC(=O)c3cccc(-c4ccc(OC)cc4OC)c3)c2)s1>>COc1ccc(-c2cccc(C(=O)Nc3cccc(-c4ccc(CC(=O)O)s4)c3)c2)c(OC)c1,,CC#N,,Cl,[Li+].[OH-],val
US20040010016A1,CCOC(OCC)OCC.N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1[S+]([O-])C(F)(F)F>>CCOC=Nc1c(S(=O)C(F)(F)F)c(C#N)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl,,O,,,,val
US20160218293A1,CC1(C)C=CC=C2C=c3cc4c5ccccc5c5cc(Br)ccc5c4cc3=C21.OB(O)c1c2ccccc2c(-c2ccc3ccccc3c2)c2ccccc12>>CC1(C)C=CC=C2C=c3cc4c5ccccc5c5cc(-c6c7ccccc7c(-c7ccc8ccccc8c7)c7ccccc67)ccc5c4cc3=C21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20150065519A1,CC1(C)OB(c2ccc(F)cc2CN2CCCC2)OC1(C)C.O=S(=O)(Nc1ccc(-c2csc(Br)n2)c(Cl)c1)C(F)(F)F>>O=S(=O)(Nc1ccc(-c2csc(-c3ccc(F)cc3CN3CCCC3)n2)c(Cl)c1)C(F)(F)F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20100222317A1,CCCSCC1CC(C#N)(CC2CC2)C1.C[Mg]Br>>CCCSCC1CC(CC2CC2)(C(C)N)C1,,CO,Cc1ccccc1,Cl,[BH4-].[Na+],val
US20020127605A1,O=C(COc1cccc([N+](=O)[O-])c1)Nc1cc(Cl)cc(Cl)c1>>Nc1cccc(OCC(=O)Nc2cc(Cl)cc(Cl)c2)c1,[Ni],CO,,NN,O,val
US05124335,CCCI.O=S(=O)(c1ccccc1)n1ccc2cccnc21>>CCCc1cc2cccnc2n1S(=O)(=O)c1ccccc1,,C1CCOC1,CCCCCC,O,[Li]CCCC,val
US20110152095A1,Cc1ccc(-c2ccc(Cl)cc2)cc1C1C(=O)C(C)(C)OC(C)(C)C1=O.O=S(=O)(Cl)Cl>>Cc1ccc(-c2ccc(Cl)cc2)cc1C1(Cl)C(=O)C(C)(C)OC(C)(C)C1=O,,ClC(Cl)Cl,,,,val
US20120295903A1,COC(=O)c1cccnc1OC>>COc1ncccc1C(=O)O,,CO,O,Cl,[Na+].[OH-],val
US20160272634A1,Cc1cc(Nc2nn([C@@H](CC#N)C3CC3)c3ccnc(OCc4ccccc4)c23)ccc1C(=O)O>>Cc1cc(Nc2nn([C@@H](CC#N)C3CC3)c3cc[nH]c(=O)c23)ccc1C(=O)O,[Pd],CCOC(C)=O,,,,val
US20090181956A1,Clc1cccnc1Cl.c1cn[nH]c1>>Clc1cccnc1-n1cccn1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20100048636A1,BrC12CCC(CC1)CC2.C=C(NC(=O)OCc1ccccc1)C(=O)OC>>COC(=O)C(CC12CCC(CC1)CC2)NC(=O)OCc1ccccc1,,c1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US05439925,COc1ccc(NC(=O)C(F)(F)F)cc1C12CC3CC(CC(C3)C1)C2>>COc1ccc(N)cc1C12CC3CC(CC(C3)C1)C2,,CO,,O,[K+].[OH-],val
US06090850,COc1cccc2c(Oc3ccccc3)cccc12>>Oc1cccc2c(Oc3ccccc3)cccc12,,CC(=O)O,,Br,,val
US20160264517A1,CCCCCC[C@@H](C)OC(=O)c1ccc(-c2ccc(O)cc2)cc1.Cc1ccc(S(=O)(=O)O[C@@H]2CCOC2)cc1>>CCCCCC[C@@H](C)OC(=O)c1ccc(-c2ccc(O[C@@H]3CCOC3)cc2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US05831115,NCc1ccccc1.O=CC=Cc1ccccc1>>C(=C/c1ccccc1)\CNCc1ccccc1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20080280925A1,CCOC(=O)c1csc(NN)n1.O=C(CC(=O)C(F)(F)F)c1ccco1>>CCOC(=O)c1csc(-n2nc(C(F)(F)F)cc2-c2ccco2)n1,,CCO,,C1COCCO1,Cl,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(Cc2ccc(F)cc2)c2nc(C)nn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(Cc2ccc(F)cc2)c2nc(C)nn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US06361815B1,OC[C@H]1O[C@@H](Oc2cc(O)cc(/C=C/c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O>>Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1,,O,,Cl,,val
US20100130506A1,OCCCCc1ccc(O)cc1.OC[C@H]1CO1>>OCCCCc1ccc(OC[C@@H](O)CO)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04304728,CSCOC(=O)c1oc(-c2ccccc2)cc(=O)c1Br.O=C(OO)c1cccc(Cl)c1>>CS(=O)COC(=O)c1oc(-c2ccccc2)cc(=O)c1Br,,ClC(Cl)Cl,,,,val
US20150011528A1,COC(=O)C(Br)CO.O=C(Nc1nc2ccccc2s1)c1cccc(Cl)c1>>COC(=O)C(CO)n1c(=NC(=O)c2cccc(Cl)c2)sc2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05869495,COC(Cc1ccc(OCCN(C)c2ccccn2)cc1)OC.C[Si](C)(C)C#N>>COC(C#N)Cc1ccc(OCCN(C)c2ccccn2)cc1,,ClCCl,,CCOCC,FB(F)F,val
US20150299121A1,Cc1c([N+](=O)[O-])ccc(F)c1C(=O)O>>Cc1c([N+](=O)[O-])ccc(F)c1CO,,C1CCOC1,,,,val
US20160002251A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@]1(C(=O)O)CCCN1>>CC(C)(C)OC(=O)N1CCC[C@]1(C)C(=O)O,,C1COCCO1,O,Cl,[Na+].[OH-],val
US05041455,CCI.Clc1nsnc1-c1cccnc1>>CC[n+]1cccc(-c2nsnc2Cl)c1.[I-],,CC(C)=O,,,,val
US20120015907A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(NS(C)(=O)=O)c(I)cc12.COC(=O)CCCCBr>>CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(N(CCCCC(=O)OC)S(C)(=O)=O)c(I)cc12,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160237090A1,C[C@H]1Cn2ncc(N3CC4(CC3=O)CN(C(=O)OC(C)(C)C)C4)c2CN1C(=O)Nc1ccc(F)c(Cl)c1>>C[C@H]1Cn2ncc(N3CC4(CNC4)CC3=O)c2CN1C(=O)Nc1ccc(F)c(Cl)c1,,CCOC(C)=O,Cl,,,val
US20110269712A1,CN[C@@H]1CC[C@H](O)c2ccccc21.Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C(=O)Cl)cs2)CC1>>Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C(=O)N(C)[C@@H]3CC[C@H](O)c4ccccc43)cs2)CC1,,ClCCl,,CCN(CC)CC,,val
US20050187300A1,CNCCOC.O=[N+]([O-])c1ccc(F)cc1OCCc1cccc(C(F)(F)F)c1>>COCCN(C)c1ccc([N+](=O)[O-])c(OCCc2cccc(C(F)(F)F)c2)c1,,CN(C)C=O,,O,,val
US20040236109A1,CC(=O)N1c2ccc(NC(=O)OC(C)(C)C)cc2C(C)=CC1(C)C.Clc1ccccc1>>CC(=O)N1c2ccc(N)cc2C(C)C(c2ccc(Cl)cc2)C1(C)C,,Clc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20030216390A1,CCCCNCc1nc2ccccc2[nH]1.O=C(Cl)c1cccc(F)c1F>>CCCCN(Cc1nc2ccccc2[nH]1)C(=O)c1cccc(F)c1F,,CCOC(C)=O,Cc1ccccc1,O=C([O-])O.[Na+],,val
US20120329649A1,CC(C)(C)OC(=O)NCC(=O)n1ccc2cc(/C=C/C(c3cc(Cl)c(F)c(Cl)c3)C(F)(F)F)ccc21>>NCC(=O)n1ccc2cc(/C=C/C(c3cc(Cl)c(F)c(Cl)c3)C(F)(F)F)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US06245769B1,COCCC(COC)Nc1cc(C)nc(Cl)c1[N+](=O)[O-]>>COCC[C@@H](COC)Nc1cc(C)nc(Cl)c1N,[Fe],CO,,CC(=O)O,,val
US20140011800A1,CC(C)(C)OC(=O)N[C@@H]1CNCC12CCC2.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)OCc2ccccc2)CC12CCC2,,ClCCl,O,O=C([O-])[O-].[Na+].[Na+],,val
US05654316,CNc1ccc(Cl)cc1.O=C1CC(c2ccccc2)CC(=O)O1>>O=C(O)CC(CC(=O)NCc1ccc(Cl)cc1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20090023729A1,CC(=O)O.COC(=O)CCCCCNC(C)=O>>CCNCCCCCC(=O)OCC,,C1CCOC1,,O,[BH4-].[Na+],val
US20100022518A1,C=CCCBr.O=C1CCN(c2cccc(C(F)(F)F)c2)CCN1>>C=CCCN1CCN(c2cccc(C(F)(F)F)c2)CCC1=O,,CN(C)C=O,,O,[H-].[Na+],val
US04973597,CN.Cc1cccc(C)c1NC(=O)c1ccc(Cl)nc1>>CNc1ccc(C(=O)Nc2c(C)cccc2C)cn1,,CCO,,,,val
US20100168192A1,NS(=O)(=O)C(F)(F)F.O=C(O)Cc1noc2ccccc12>>O=C(Cc1noc2ccccc12)NS(=O)(=O)C(F)(F)F,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US20120184565A1,Cc1ncn(-c2ccc([N+](=O)[O-])cc2OCCCN)n1.Fc1ccc(C2CCc3c(Cl)nc(Cl)nc32)c(F)c1>>Cc1ncn(-c2ccc([N+](=O)[O-])cc2OCCCNc2nc(Cl)nc3c2CCC3c2ccc(F)cc2F)n1,,CC#N,,CCN(C(C)C)C(C)C,,val
US04859692,C=CCn1c(=O)c2ccc(NC(=O)CC3CCCC3)cc2n1Cc1ccc(C(=O)OC)cc1OC>>CCCn1c(=O)c2ccc(NC(=O)CC3CCCC3)cc2n1Cc1ccc(C(=O)OC)cc1OC,[Pd],CCOC(C)=O,,,,val
US20150183791A1,CC(C)CNC(=O)c1cccc(B2OC(C)(C)C(C)(C)O2)c1.Clc1ccc2nccn2n1>>CC(C)CNC(=O)c1cccc(-c2ccc3nccn3n2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,O,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20020173527A1,C[Mg]Br.Cc1ccc(S(=O)(=O)n2cc(C=O)c3ccc(C(=O)Nc4c(Cl)cncc4Cl)cc32)cc1>>Cc1ccc(S(=O)(=O)n2cc(C(C)O)c3ccc(C(=O)Nc4c(Cl)cncc4Cl)cc32)cc1,,C1CCOC1,CCOCC,,,val
US20130261106A1,CC(C)Oc1cc(C2=CCN(CCO)CC2)ccc1[N+](=O)[O-]>>CC(C)Oc1cc(C2CCN(CCO)CC2)ccc1N,[Pd],CCO,ClCCl,O=C[O-].[NH4+],,val
US20120214762A1,C1=COCCC1.N#Cc1nc[nH]n1>>N#Cc1ncn(C2CCCCO2)n1,,ClCCCl,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20100222396A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN=[N+]=[N-].CI>>CN1C(=O)O[C@H](CN=[N+]=[N-])[C@@H]1Cc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US06169090A,COc1nccc2cc(C(C)=O)oc12.O=C1CCC(=O)N1Br>>COc1ncc(Br)c2cc(C(C)=O)oc12,,CC#N,,,,val
US20120258982A1,COC(=O)c1c(C)c(=O)c2ccc(Cl)cc2n1-c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1c(CBr)c(=O)c2ccc(Cl)cc2n1-c1ccccc1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20100004459A1,COCCl.N#Cc1cc(Br)ccc1O>>COc1cc(Br)cc(C#N)c1OC,,CN(C)C=O,,CC(C)(C)O[K],,val
US05302593,C1COCCN1.O=C1NC(=O)c2c(CCCCBr)cccc21>>O=C1NC(=O)c2c(CCCCN3CCOCC3)cccc21,,CCOCC,,,,val
US20070032515A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc(-c2c(C)n[nH]c2N)cc1OCC1CCN(C(=O)OC(C)(C)C)CC1.O=C(O)C(F)(F)F.O=Cc1ccc(O)cc1>>COc1cc2c(-c3ccc(OC(=O)OC(C)(C)C)cc3)nc3[nH]nc(C)c3c2cc1OCC1CCN(C)CC1.O=C(O)C(F)(F)F,CN(C)c1ccncc1,ClCCl,O,,,val
US04182776,CS(=O)(=O)Cl.OCCCCCCOc1ccccc1>>CS(=O)(=O)OCCCCCCOc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20100249094A1,CC(C)(C)[Si](C)(C)OCCBr.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N)c(-c3cccc(C(=O)NC(C)(C)c4ccccc4)c3)cc12.CS(=O)(=O)Cl>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(CCO)S(C)(=O)=O)c(-c3cccc(C(=O)NC(C)(C)c4ccccc4)c3)cc12,,CCOC(C)=O,c1ccncc1,O=C([O-])[O-].[Na+].[Na+],,val
US20150329538A1,CC(C)(C)N.Clc1ncc2cccc(Br)c2n1>>CC(C)(C)Nc1ncc2cccc(Br)c2n1,,O,,CN(C)C=O,,val
US05183921,COS(=O)(=O)OC.N#CC(=NO)c1ccccc1Oc1ccc(Cl)cc1>>CON=C(C#N)c1ccccc1Oc1ccc(Cl)cc1,,CN(C)C=O,,CCOCC,O=C([O-])[O-].[K+].[K+],val
US06458852B1,Nc1cccc(Oc2ccccc2)c1.O=Cc1cccc(O)c1>>Oc1cccc(CNc2cccc(Oc3ccccc3)c2)c1,,ClCCCl,,CC(=O)O,[Na+].[OH-],val
US20090036450A1,Cc1noc(-c2ccnc(Cl)c2)c1CO.O=S(Cl)Cl>>Cc1noc(-c2ccnc(Cl)c2)c1CCl,,ClC(Cl)Cl,,c1ccncc1,,val
US06608070B1,COC(=O)Cc1c(C(=O)c2cccn2C)[nH]c2ccc(Cl)cc12>>Cn1cccc1C(=O)c1[nH]c2ccc(Cl)cc2c1CC(=O)O,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20070185133A1,CSc1ncc(C(F)(F)F)c(-c2cc3ccccc3s2)n1.[OH-]>>Oc1ncc(C(F)(F)F)c(-c2cc3ccccc3s2)n1,,C1COCCO1,,Cl,,val
US05563288,CN(C)CCO.COC(=O)OC(C)C>>CC(C)OC(=O)OCCN(C)C,,CO,,,,val
US20100210672A1,CN(C)C=O.COc1ncc(C(=O)O)c(OC)n1>>COC(=O)c1cnc(OC)nc1OC,,CN(C)C=O,,CCN(CC)CC,,val
US04694017,NC(CC1C(=O)Nc2ccccc21)C(=O)O.O=C(O)c1ccc(Cl)cc1>>O=C(NC(CC1C(=O)Nc2ccccc21)C(=O)O)c1ccc(Cl)cc1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US04881967,C=CCc1c(O)cccc1N1C(=O)C2=C(CCCC2)C1=O>>CC1Cc2c(cccc2N2C(=O)C3=C(CCCC3)C2=O)O1,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04625047,CCOC(=O)CC(C)=O.CN(C)CCC(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl>>O=C(O)COc1ccc(C2=CC(=O)CCC2)c(Cl)c1Cl,,CCO,,C[O-].[Na+],,val
US05597831,NCCO.O=C1c2ccccc2-c2c1c1ccccc1c(=O)n2CCCl>>O=C1c2ccccc2-c2c1c1ccccc1c(=O)n2CCNCCO,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130178459A1,CC1(C)OB(c2ccc(OCCCBr)cc2)OC1(C)C.CCN(CC)CCN>>CCN(CC)CCNCCCOc1ccc(B2OC(C)(C)C(C)(C)O2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130245042A1,Nc1nccc(Cl)c1I.O=CC(Br)CC(F)(F)F>>FC(F)(F)Cc1cnc2c(I)c(Cl)ccn12,,CCO,,,,val
US05278141,C[C@]12CC[C@H]3[C@@H](CCC4=CC(O)CC[C@@]43CO)[C@@H]1CCC2=O.Cc1ccc(S(=O)(=O)NN)cc1>>Cc1ccc(S(=O)(=O)NN=C2CC[C@H]3[C@@H]4CCC5=CC(O)CC[C@]5(CO)[C@H]4CC[C@]23C)cc1,,CO,,,,val
US20150284321A1,Nc1cccc(NC(=O)Nc2ccccc2)c1.O=S(=O)(Cl)c1ccccc1>>O=C(Nc1ccccc1)Nc1cccc(NS(=O)(=O)c2ccccc2)c1,,CCOC(C)=O,,CCN(CC)CC,,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(Oc3ncc(NC(=O)OC(C)(C)C)s3)cc(C)c21>>Cc1cc(Oc2ncc(NC(=O)OC(C)(C)C)s2)cc2c1C(CC(=O)O)OB2O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20130029980A1,C=CC[Sn](CCCC)(CCCC)CCCC.Cc1cc([N+](=O)[O-])c(NCCCc2ccccc2)cc1Br>>C=CCc1cc(NCCCc2ccccc2)c([N+](=O)[O-])cc1C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,O,N#N,,val
US20010001101A1,CCOC(=O)c1cnc2c3c(ccc2c1)C(=O)C([N+](=O)[O-])C=N3>>O=C(O)c1cnc2c3c(ccc2c1)C(=O)C([N+](=O)[O-])C=N3,,O,,CC(=O)O,[Na+].[OH-],val
US20100305070A1,COc1ccc2oc(C=O)cc2c1>>COc1ccc2oc(CO)cc2c1,,CCO,,[BH4-].[Na+],,val
US20160039838A1,C1CO[C@H]2CNC[C@@H]2O1.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CBr>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1C[C@@H]2OCCO[C@H]2C1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,O,val
US04719046,CC(CO)(CO)NCc1cc2c3ccccc3ccc2c2ccccc12.CC(O)C(=O)O>>CC(O)C(=O)OCC(C)(CO)NCc1cc2c3ccccc3ccc2c2ccccc12,,CO,,,,val
US20100029651A1,COc1ccc(CN)c(OC)c1.O=Cc1cn(-c2ccc(I)cc2)nc1-c1ccccc1>>COc1ccc(CNCc2cn(-c3ccc(I)cc3)nc2-c2ccccc2)c(OC)c1,,CC(Cl)Cl,,CC(=O)O,O=C([O-])O.[Na+],val
US20100256172A1,CCOC(=O)c1sc(Br)c(C#N)c1-c1ccc(Cl)cc1Cl>>N#Cc1c(Br)sc(C(=O)O)c1-c1ccc(Cl)cc1Cl,,C1CCOC1,,O,[Na+].[OH-],val
US20060142585A1,N#C[C@@H]1C[C@H](F)CN1C(=O)CN[C@@H]1CC[C@H](Cn2cncn2)C1.O=S(=O)(O)c1cccc2c(S(=O)(=O)O)cccc12>>N#C[C@@H]1C[C@H](F)CN1C(=O)CN[C@@H]1CC[C@H](Cn2cncn2)C1.O=S(=O)(O)c1cccc2c(S(=O)(=O)O)cccc12,,CC(C)=O,,,,val
US20030125334A1,CC(C)(C)OC(=O)N1CCNCC1.Nc1ncc(Br)nc1Br>>CC(C)(C)OC(=O)N1CCN(c2nc(Br)cnc2N)CC1,,CCOC(C)=O,,,,val
US20070037812A1,CCOC(=O)CCc1ccc(Oc2cc(C)cc(Oc3ccc(C(F)(F)F)cc3-c3ccccn3)c2)cc1C>>Cc1cc(Oc2ccc(CCC(=O)O)c(C)c2)cc(Oc2ccc(C(F)(F)F)cc2-c2ccccn2)c1,,CCO,O,Cl,[Na+].[OH-],val
US20090181942A1,COc1cccc(C(=O)c2cccc(Cl)c2N)c1OC>>COc1cccc(C(O)c2cccc(Cl)c2N)c1OC,,CO,,[BH4-].[Na+],,val
US04582862,CC(C)(C(=O)c1ccc(Cl)cc1)N1CCOCC1.CC(O)S>>CC(C)(C(=O)c1ccc(SCCO)cc1)N1CCOCC1,,CCOCC,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20120202802A1,CC(C)[C@@H](NC(=O)[C@@H]1CCC(CC=O)(NC(=O)OC(C)(C)C)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1>>CC(C)[C@@H](NC(=O)[C@@H]1CCC(CCO)(NC(=O)OC(C)(C)C)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1,,CO,,[BH4-].[Na+],,val
US20110257174A1,CC(=O)c1cc(Br)cc(C(=O)O)c1O>>CC(=O)c1cccc(C(=O)O)c1O,[Pd],CCO,,,,val
US20090131336A1,NCc1cc(-c2ccco2)on1.O=C(O)Cc1ccccc1>>O=C(Cc1ccccc1)NCc1cc(-c2ccco2)on1,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20080319005A1,CC(C)(C)C(=O)CC#N.Cc1ccccc1NN>>Cc1ccccc1-n1nc(C(C)(C)C)cc1N,,Cc1ccccc1,,CCN(CC)CC,Cl,val
US20090082365A1,COc1ccc(C(=O)Cl)c([N+](=O)[O-])c1.Nc1ccc(Cl)cc1>>COc1ccc(C(=O)Nc2ccc(Cl)cc2)c([N+](=O)[O-])c1,,C1CCOC1,,,,val
US05216003,CCOP(=O)(Cc1cccc(C(=O)OC)c1[N+](=O)[O-])OCC>>CCOP(=O)(Cc1cccc(C(=O)O)c1[N+](=O)[O-])OCC,,CCO,,[Na+].[OH-],,val
US20050124604A1,CCOC(=O)c1cc(F)c(SCC)nc1NCc1ccc(OC)cc1>>CCOC(=O)c1cc(F)cnc1NCc1ccc(OC)cc1,[Ni],CCO,,,,val
US05124350,CCCc1c(O)ccc(C(=O)NC)c1O.CCCc1c(OCCCI)ccc2c1OC(C(=O)OC)CC2>>CCCc1c(OCCCOc2ccc3c(c2CCC)OC(C(=O)OC)CC3)ccc(C(=O)NC)c1O,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04418197,COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCCCCOS(=O)(=O)c2ccc(C)cc2)C1c1cccc([N+](=O)[O-])c1.O=C1C=C(c2ccc3c(c2)OCO3)N=N1>>COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCCCCOc2cc(-c3ccc4c(c3)OCO4)[nH]n2)C1c1cccc([N+](=O)[O-])c1,,CN(C)C=O,,[H][H],[H-].[Na+],val
US20100261753A1,Cl.O[C@H]1[C@H](OCc2ccccc2)CN(Cc2ccccc2)C[C@H]1CF>>Cl.O[C@@H]1CNC[C@@H](CF)[C@H]1O,,CCO,,,,val
US04845293,NCC(O)CO.O=[N+]([O-])c1c(Cl)cccc1Cl>>O=[N+]([O-])c1c(Cl)cccc1NCC(O)CO,,CN1CCCC1=O,,,,val
US20020099038A1,CCOC(=O)c1ccc(N=Nc2ccc3c(c2)C(O)CCC3(C)C)cc1>>CC1(C)CCC(=O)c2cc(N)ccc21,[Pd],CCOC(C)=O,,,,val
US06511974B1,Cc1ccn(-c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)c(Cl)c2)n1.O=C1CCC(=O)N1Br>>Cc1ccn(-c2ccc(C(=O)N3Cc4ccc(Br)n4Cc4ccccc43)c(Cl)c2)n1,,ClCCl,,,,val
US20120295923A1,CCOC(=O)/C=C/CC[C@H](C=O)N(Cc1ccccc1)Cc1ccccc1.FC(F)(F)c1ccc([Mg]Br)cc1>>CCOC(=O)/C=C/CC[C@H]([C@@H](O)c1ccc(C(F)(F)F)cc1)N(Cc1ccccc1)Cc1ccccc1,,C1CCOC1,,,,val
US20130131017A1,CC1(C)OB(O)c2cc(C=O)ccc21.C[N+](=O)[O-]>>CC1(C)OB(O)c2cc(/C=C/[N+](=O)[O-])ccc21,,CC(=O)O,O,CCOC(C)=O,,val
US04028356,COC(=O)CCCC(=O)COS(C)(=O)=O.NNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NC1>>COC(=O)CCCC(CO)=NNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NC1,,C1CCOC1,,,,val
US05481001,CCCCCC(=O)Cl.CCCCCN>>CCCCCNC(=O)CCCCC,,ClCCl,,,,val
US20130331419A1,CCC(C#CC(=O)O)(c1ccc(Cl)cc1)n1ccc2c(N(COCC[Si](C)(C)C)S(C)(=O)=O)cccc21.[NH4+]>>CCC(C#CC(N)=O)(c1ccc(Cl)cc1)n1ccc2c(N(COCC[Si](C)(C)C)S(C)(=O)=O)cccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100279868A1,O=Cc1cnc(-c2ccc(Cl)cc2)s1>>OCc1cnc(-c2ccc(Cl)cc2)s1,,CO,,[BH4-].[Na+],,val
US05407959,BrP(Br)Br.CC(=O)N(C)c1ccc(CO)cc1>>CC(=O)N(C)c1ccc(CBr)cc1,,ClCCl,,,,val
US20060004084A1,O=C(O)CCc1ccc2c(c1)COC2=O.OC12CC3CC(CC(C3)C1)C2>>O=C(CCc1ccc2c(c1)COC2=O)OC12CC3CC(CC(C3)C1)C2,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20080234327A1,CCOC(=O)OCC.O=C1CCc2cc(Br)ccc2C1>>CCOC(=O)C1C(=O)CCc2cc(Br)ccc21,,c1ccccc1,,CC(=O)O,[H-].[Na+],val
US20060014816A1,O=C1CCc2ccc(Br)cc21.OCCO>>Brc1ccc2c(c1)C1(CC2)OCCO1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05144045,C=C(COCCCCCCCCCCCCCCCC)C(=O)OCC.CCCCCCCCCCCCCCCCS>>CCCCCCCCCCCCCCCCOCC(CSCCCCCCCCCCCCCCCC)C(=O)OCC,,CCO,,CCN(CC)CC,,val
US20070032478A1,Cc1cc(C(=O)Cl)n(C(C)(C)C)n1.Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3)c1>>Cc1cc(C(=O)Nc2cccc(C(=O)c3ccc4c(c3)NC(=O)C4)c2)n(C(C)(C)C)n1,,C1CCOC1,,,,val
US20100204246A1,C[C@H](Nc1nc(Cl)ccc1[N+](=O)[O-])c1ccc(F)cn1.Nc1cc(C2CC2)[nH]n1>>C[C@H](Nc1nc(Nc2cc(C3CC3)[nH]n2)ccc1[N+](=O)[O-])c1ccc(F)cn1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US05707997,CC(=O)OC(C)CCc1cc(O)n2nccc2n1.O=P(Cl)(Cl)Cl>>CC(=O)OC(C)CCc1cc(Cl)n2nccc2n1,,Cc1ccccc1,,CCN(CC)CC,,val
US20140200197A1,CC(C)(C)OC(=O)N1C[C@@H](CCc2c(F)cncc2NC(=O)[C@@H](N=[N+]=[N-])[C@@H](c2ccc(F)cc2)c2cc(F)cc(F)c2)OC[C@@H]1COC(=O)NCC(F)(F)F>>CC(C)(C)OC(=O)N1C[C@@H](CCc2c(F)cncc2NC(=O)[C@@H](N)[C@@H](c2ccc(F)cc2)c2cc(F)cc(F)c2)OC[C@@H]1COC(=O)NCC(F)(F)F,[Pd],CO,,[H][H],,val
US20120157452A1,CO.Cc1ccc(O)c(F)c1C(=O)O>>COC(=O)c1c(C)ccc(O)c1F,,CO,,C[Si](C)(C)C=[N+]=[N-],,val
US20080194549A1,CC(C)(C)OC(=O)N1C[C@@H](CO)[C@H](C(C)(C)O[SiH2]C(C)(C)C)C1>>CC(C)(C)OC(=O)N1C[C@@H](C=O)[C@H](C(C)(C)O[SiH2]C(C)(C)C)C1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20040039038A1,CN.O=Cc1ccc(OCc2ccccc2)c(Br)c1>>CNCc1ccc(OCc2ccccc2)c(Br)c1,,CO,,Cl,[BH3-]C#N.[Na+],val
US20040058964A1,Cc1cc(O)cc(=O)o1.N#Cc1cccc(CN)c1>>Cc1cc(O)cc(=O)n1Cc1cccc(C#N)c1,,O,,,,val
US20040044059A1,COc1ccc(C=O)c(OC(C)C)c1OC(C)C.[Li]C>>COc1ccc(C(C)O)c(OC(C)C)c1OC(C)C,,CCOCC,,,,val
US04389524,CN=NNc1ccc(C)cc1.O=C(Cc1ccccc1)N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)C(=O)CS[C@H]12>>COC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](NC(=O)Cc3ccccc3)[C@H]2SC1,,c1ccccc1,,,,val
US20130196974A1,C[Mg]Br.O=Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(Cl)c2c1>>CC(O)c1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(Cl)c2c1,,C1CCOC1,,,,val
US20100298341A1,CC(C)(C)OC(=O)CBr.C[C@@H]1CN(C2CCCCC2c2ccccc2)CCN1>>C[C@@H]1CN(C2CCCCC2c2ccccc2)CCN1CC(=O)OC(C)(C)C,,CC#N,,CCN(C(C)C)C(C)C,,val
US20110183989A1,Nc1oncc1-c1ccccc1.O=C(n1ccnc1)n1ccnc1.O=C1C2CNCCN2C(=O)N1[C@@H]1C[C@H]1c1ccccc1>>O=C(Nc1oncc1-c1ccccc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05358947,N#CCC(=O)c1ccccc1.NNC(N)=O>>NC(=O)n1nc(-c2ccccc2)cc1N,,CCO,,Cl,C[O-].[Na+],val
US20140296245A1,COC(=O)[C@@H]1CNC(=O)C[C@H]1c1cc(F)c(F)cc1F>>OC[C@@H]1CNCC[C@H]1c1cc(F)c(F)cc1F,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20030013704A1,O=C(O)CCc1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1>>O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(CCCO)ccc1Cl,,C1CCOC1,,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20060030612A1,CCOC(=O)C1CCN(c2ccc(-c3c4cccc(C(F)(F)F)c4nn3Cc3ccccc3)cc2)CC1>>O=C(O)C1CCN(c2ccc(-c3c4cccc(C(F)(F)F)c4nn3Cc3ccccc3)cc2)CC1,,CO,,Cl,[Na+].[OH-],val
US06350749B1,Cc1ccc(S(=O)(=O)NNC2=CC(=O)CC(c3ccccc3Cl)C2)cc1.O=C(CBr)C(F)(F)F>>O=C1CC(c2ccccc2Cl)Cc2nncc(C(F)(F)F)c21,,CO,,O=C([O-])[O-].[K+].[K+],,val
US04214097,CC=CC(C)(C)C(C)C(=O)OCC.O=C1CCC(=O)N1Br>>CCOC(=O)C(C)C(C)(C)C=CCBr,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US05182303,O=C(O)C(CSc1ccccc1F)c1ccc(F)cc1>>O=C1c2cccc(F)c2SCC1c1ccc(F)cc1,,O=S(Cl)Cl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US04745121,C#CCCCI.CCOC(=O)c1cnc2[nH]ncc2c1OCC>>C#CCCCn1ncc2c(OCC)c(C(=O)OCC)cnc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160002266A1,COc1ccc(CNc2cc3c(cn2)CN(Cc2ccc(OC)cc2OC)C3)c(OC)c1>>Nc1cc2c(cn1)CNC2,,O=C(O)C(F)(F)F,,,,val
US04284644,COS(=O)(=O)OC.O=C(O)c1ccc2c(c1)C(=O)C1(CC1)O2>>COC(=O)c1ccc2c(c1)C(=O)C1(CC1)O2,,CC(C)=O,,CN(C)C=O,O=C([O-])O.[Na+],val
US20070043009A1,CC(C)(C)OC(=O)N1CCC[C@@H](O)C1.COc1cc2c(Cl)ncnc2cc1O>>COc1cc2c(Cl)ncnc2cc1O[C@H]1CCCN(C(=O)OC(C)(C)C)C1,,ClCCl,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030114432A1,CCO.CCOC(=O)c1nn(-c2ccc3c(c2)OCO3)c2c1CN(C(C)=O)c1ccc(N)cc1-2.N>>CC(=O)N1Cc2c(C(N)=O)nn(-c3ccc4c(c3)OCO4)c2-c2cc(N)ccc21.CC(=O)O,,CCO,,,,val
US06284863B1,C=C(C)C(=O)OC(C)(C)C.C=CN1CCCC1=O.C=COCC.C=Cc1ccc(O)cc1.CC(=O)CC(C)C.COCC(C)OC(C)=O.Cc1ccc(S(=O)(=O)O)cc1>>C=C(C)C(=O)OC(C)(C)C.C=Cc1ccc(O)cc1.C=Cc1ccc(OC(C)N2CCCC2=O)cc1.C=Cc1ccc(OC(C)OCC)cc1,,CC(=O)CC(C)C,,,,val
US20100029684A1,COC[C@H](C1CC1)n1cc(C#N)nc(Nc2cc(C)c(O)nc2C)c1=O.C[Si](C)(C)OC(=O)C(F)(F)S(=O)(=O)F>>COC[C@H](C1CC1)n1cc(C#N)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O,,CC#N,,[Cs+].[F-],,val
US05001125,CCOC(=O)N1CCN(c2cc(C)c(Cl)nn2)CC1>>Cc1cc(N2CCNCC2)nnc1Cl,,CCCCO,,[K+].[OH-],,val
US20150266874A1,CCOC(=O)c1nc2ccccn2n1.CCOC(C)=O>>CCOC(=O)CC(=O)c1nc2ccccn2n1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US03947470,CCN(CC)CCCCl.COC(=O)c1ccccc1O>>CCN(CC)C(C)COc1ccccc1C(=O)O,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120238574A1,O=[N+]([O-])c1ccc(OC2CCN(Cc3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)c(Br)c1>>Nc1ccc(OC2CCN(Cc3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)c(Br)c1,[Fe],CC(C)O,ClCCl,Cl,,val
US20130266563A1,COc1cc2nc(C)[nH]c(=O)c2cc1OCCCN1CCOCC1.O=S(Cl)Cl>>COc1cc2nc(C)nc(Cl)c2cc1OCCCN1CCOCC1,,CN(C)C=O,,N,,val
US20130210844A1,Cc1cc(Br)c2c(Nc3cccc(C(F)(F)F)c3)ncnc2c1[N+](=O)[O-]>>Cc1ccc2c(Nc3cccc(C(F)(F)F)c3)ncnc2c1N,[Pd],CCO,,,,val
US20060100245A1,C1CCNC1.CC(C)(C)c1ccc(NC(=O)c2ccc(-c3ncccc3C=O)cc2)cc1>>CC(C)(C)c1ccc(NC(=O)c2ccc(-c3ncccc3CN3CCCC3)cc2)cc1,,CC(Cl)Cl,,CC(=O)O,,val
US20140275028A1,ClCc1ccc2ccccc2n1.O=[N+]([O-])c1cc(O)ccc1F>>O=[N+]([O-])c1cc(OCc2ccc3ccccc3n2)ccc1F,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20010039277A1,CCOC1(O[Si](C)(C)C)CC1.c1ccc(-c2cnc(-c3ccc(N4CCNCC4)nc3)[nH]2)cc1>>c1ccc(-c2c[nH]c(-c3ccc(N4CCN(C5CC5)CC4)nc3)n2)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20090209524A1,CCCCCN.COC(=O)c1ccc(Cc2c(C)nc(N)nc2Cl)c(F)c1>>CCCCCNc1nc(N)nc(C)c1Cc1ccc(C(=O)OC)cc1F,,C1COCCO1,,,,val
US05726295,Cc1ccc(S(=O)(=O)N=[N+]=[N-])cc1.O=c1cc(O)c2ccc(OCc3ccccc3)cc2o1>>[N-]=[N+]=C1C(=O)Oc2cc(OCc3ccccc3)ccc2C1=O,,C1CCOC1,,CCN(CC)CC,,val
US20110014186A1,BrCCCc1ccccc1.CN(C)C=NS(=O)(=O)c1cc(C(=O)c2ccc(O)cc2)ccc1Cl>>NS(=O)(=O)c1cc(C(=O)c2ccc(OCCCc3ccccc3)cc2)ccc1Cl,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120034250A1,C[C@@H]1CCNC[C@@H]1n1ccc2cnc3[nH]ccc3c21.N#CCN(C(=O)[O-])c1ccc([N+](=O)[O-])cc1>>CC1CCN(C(=O)NCC#N)CC1n1ccc2cnc3[nH]ccc3c21,,CN(C)C=O,,CCN(CC)CC,O,val
US20090286986A1,C1CCOC1.Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1ccccn1>>O=C1CCC(N2C(=O)c3cccc(NC(=O)Cc4ccccc4)c3C2=O)C(=O)N1,,CO,,Cl,,val
US05153337,CC(C)=CC=O.C[Si](C)(C)Cl>>C=C(C)C=CO[Si](C)(C)C,,CC#N,,CCN(CC)CC,[I-].[Na+],val
US20100197683A1,CCCCc1c(Cc2ccc(-c3ccccc3C#N)c(F)c2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2ccnn12.O=C([O-])O.[NH3+]O>>CCCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)c(F)c2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2ccnn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20140315917A1,Cn1cc(-c2cc(Oc3ccc(N)cc3Cl)ccn2)cn1.O=C(Cl)N1CCN(C2CCOCC2)C1=O>>Cn1cc(-c2cc(Oc3ccc(NC(=O)N4CCN(C5CCOCC5)C4=O)cc3Cl)ccn2)cn1,,ClCCl,,O,,val
US20080214641A1,CC(=O)OCC(=O)Cl.Cc1cc2c(cnn2-c2ccc(F)cc2)cc1O[C@H](c1ccccc1)[C@H](C)N>>Cc1cc2c(cnn2-c2ccc(F)cc2)cc1O[C@H](c1ccccc1)[C@H](C)NC(=O)CO,,C1CCOC1,,CCN(CC)CC,,val
US20090186870A1,CN1CCNCC1.NC(=O)c1cc(F)ccc1Cl>>CN1CCN(c2ccc(Cl)c(C(N)=O)c2)CC1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US06121239,CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O.N=C(N)NCCC[C@H](NC(=O)CN)C(=O)Nc1ccc([N+](=O)[O-])cc1>>CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)Nc1ccc([N+](=O)[O-])cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20060122399A1,CCOC(OCC)c1nc(-c2cccc(C)n2)nn1C.Cl.O>>Cc1cccc(-c2nc(C=O)n(C)n2)n1.Cl.O,,O,,,,val
US20080293712A1,COc1cc2ncc(C#N)c(/C=C/N(C)C)c2cc1OC>>COc1cc2ncc3c(N)nccc3c2cc1OC,,CC(=O)O,,,,val
US20120190666A1,CC(=O)Nc1cc(-c2c(Nc3ccn(C(=O)OC(C)(C)C)n3)nc3cccnn23)nc(C)n1>>CC(=O)Nc1cc(-c2c(Nc3cc[nH]n3)nc3cccnn23)nc(C)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04393210,O=C(O)/C=C\C(=O)O.O=c1c2ccccc2c(-c2ccccc2)cn1CCCN1CCCCC1>>O=C(O)/C=C\C(=O)O.O=c1c2ccccc2c(-c2ccccc2)cn1CCCN1CCCCC1,,CCOC(C)=O,,,,val
US20060046977A1,CC(C)N(CCOc1ccc(-c2oc3nccc(NCCN4CCN(C(=O)OC(C)(C)C)CC4)c3c2-c2ccccc2)cc1)C(C)C>>CC(C)N(CCOc1ccc(-c2oc3nccc(NCCN4CCNCC4)c3c2-c2ccccc2)cc1)C(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050192347A1,CC(C)(CO)CCCN.O=C=NCCc1ccccc1>>CC(C)(CO)CCCNC(=O)NCCc1ccccc1,,ClCCl,,,,val
US20110015175A1,COc1cc(Nc2n[nH]c(C3(CCCCCl)SCCCS3)n2)ccc1-n1cnc(Cl)c1>>COc1cc(Nc2nc3n(n2)CCCCC32SCCCS2)ccc1-n1cnc(Cl)c1,,CN(C)C=O,,[I-].[K+],,val
US05270308,CC1(C)N=C(c2ccccn2)c2cc(C#N)ccc2O1.O=C(OO)c1cccc(Cl)c1>>CC1(C)N=C(c2cccc[n+]2[O-])c2cc(C#N)ccc2O1,,ClCCl,,,,val
US20160218303A1,N#Cc1cccc(F)c1[N+](=O)[O-].Nc1ccccc1-c1ccccc1>>N#Cc1cccc(Nc2cccc(-c3ccccc3)c2)c1[N+](=O)[O-],,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20090087480A1,CC(C)(C)OC(=O)N1CCC(CCCBr)CC1.N#Cc1ccc(O)cc1>>CC(C)(C)OC(=O)N1CCC(CCCOc2ccc(C#N)cc2)CC1,,Cc1ccccc1,O,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US06808766B1,C=CCBr.Cc1c(C(=O)O)cc(C(=O)O)c(C)c1O>>C=CCOc1c(C)c(C(=O)O)cc(C(=O)O)c1C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04036850,Nc1ccccc1.O=C=NC(=O)C(Br)CBr>>O=C(NC(=O)C(Br)CBr)Nc1ccccc1,,c1ccccc1,,,,val
US20050124628A1,Cl.O=C1CCC(=O)N1Cl.O=S(=O)(c1ccccc1)c1cnc2c(N3CCNCC3)cccc2c1>>Cl.O=S(=O)(c1ccccc1)c1cnc2c(N3CCNCC3)c(Cl)ccc2c1,,CC(=O)O,,,,val
US20090264433A1,COC(OC)c1ccc(COc2ncc(-c3cc(Cl)c(O)c(Cl)c3)nn2)cc1>>O=Cc1ccc(COc2ncc(-c3cc(Cl)c(O)c(Cl)c3)nn2)cc1,,Cl,,CCO,,val
US20070161638A1,CC(C)S(=O)(=O)N[C@H]1Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2C1.FC(F)(F)c1cccc(Br)n1>>CC(C)S(=O)(=O)N[C@H]1Cc2ccc(-c3cccc(C(F)(F)F)n3)cc2C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20120289526A1,CI.Cc1c(O)cccc1[N+](=O)[O-]>>COc1cccc([N+](=O)[O-])c1C,,CN(C)C=O,,O,[H-].[Na+],val
US20090118199A1,CC(C)Oc1ccc(C=O)cc1.CCc1ccc(Oc2ccc(C3=NCC(=O)O3)cc2)cc1>>CCc1ccc(Oc2ccc(C3=N/C(=C\c4ccc(OC(C)C)cc4)C(=O)O3)cc2)cc1,,c1ccccc1,,CCN(CC)CC,O,val
US20160136140A1,CC(C)(N)Cc1c[nH]c2ccccc12.COC(=O)/C=C/c1ccc(C=O)c(F)c1>>COC(=O)/C=C/c1ccc(C2NC(C)(C)Cc3c2[nH]c2ccccc32)c(F)c1,,CC(=O)O,,,,val
US20050282819A1,CC1(C)c2ccc(CCN3CCN(c4noc5ccccc45)CC3)cc2C(C)(C)C1O.CS(=O)(=O)O>>CC1(C)c2ccc(CCN3CCN(c4noc5ccccc45)CC3)cc2C(C)(C)C1OS(C)(=O)=O,,CCOC(C)=O,,,,val
US20110003858A1,CCOC(=O)c1cc(-c2ccnn2-c2ccc(C#N)cc2)c(C)n(-c2cccc(C(F)(F)F)c2)c1=O>>Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cc(C(=O)O)c(=O)n1-c1cccc(C(F)(F)F)c1,,C1CCOC1,,[Li+].[OH-],,val
US20140275021A1,COc1ccncc1N.N#CCC(=O)O>>COc1ccncc1NC(=O)CC#N,CN(C)c1ccncc1,C1CCOC1,,CCN=C=NCCCN(C)C,Cl,val
US06756498B2,NO.O=C(Cc1ccc(C(F)(F)F)cn1)c1cccc(F)c1>>ON=C(Cc1ccc(C(F)(F)F)cn1)c1cccc(F)c1,,O,,CO,[Na+].[OH-],val
US20130150381A1,C1COCCO1.CC(C)(Sc1ccccc1Br)C(=O)[O-].N#Cc1ccc(B(O)O)cc1>>CCOC(=O)C(C)(C)Sc1ccccc1-c1ccc(C#N)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20100174088A1,Cc1csc(Cl)c1N.S=C(Cl)Oc1ccccc1>>NC(=S)Oc1ccccc1,,CN1CCCC1=O,,Cl,O=C([O-])O.[Na+],val
US20120004222A1,NC(=O)c1nc(CN2CCC(F)(F)CC2)c2ccccn12>>N#Cc1nc(CN2CCC(F)(F)CC2)c2ccccn12,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20070197581A1,CC#N.O=S(=O)(c1ccc(Cl)cc1)C1c2c(F)ccc(F)c2OCC1CCI>>N#CCCC1COc2c(F)ccc(F)c2C1S(=O)(=O)c1ccc(Cl)cc1,,Cl,,,,val
US20150191452A1,CS(=O)(=O)O[C@H]1CCN(Cc2ccc(C(F)F)cc2)C1=O.Oc1ccc([C@@H]2CCNC[C@H]2F)cc1>>O=C1C(N2CC[C@@H](c3ccc(O)cc3)[C@H](F)C2)CCN1Cc1ccc(C(F)F)cc1,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20120053173A1,CCOC(=O)CCN(C)C(=O)c1ccc(NC(CCCCOC)c2oc3ccc(OC)cc3c2C)cc1>>COCCCCC(Nc1ccc(C(=O)N(C)CCC(=O)O)cc1)c1oc2ccc(OC)cc2c1C,,CCO,,C1CCOC1,[Na+].[OH-],val
US20080167348A1,CC(C)(C)OC(=O)N1CCC(c2ccc(N)c(S(C)(=O)=O)c2)CC1.Cn1c(S(=O)(=O)Cl)cc2cc(F)ccc21>>Cn1c(S(=O)(=O)Nc2ccc(C3CCN(C(=O)OC(C)(C)C)CC3)cc2S(C)(=O)=O)cc2cc(F)ccc21,CN(C)c1ccncc1,ClCCCl,ClCCl,,,val
US20160002264A1,C=CC[Mg]Br.CON(C)C(=O)CC1CC1>>C=CCC(=O)CC1CC1,,C1CCOC1,,,,val
US20150376130A1,CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.O=C(O)c1cc(C(F)(F)F)ccc1NCC(F)F>>C#CC(C)(C)NC(=O)c1cc(C(F)(F)F)ccc1NCC(F)F,,ClCCl,,On1nnc2ccccc21,,val
US20080194535A1,COc1ccc2c(c1)[C@@H](NC(=O)C(F)(F)F)C[C@H]2O>>COc1ccc2c(c1)[C@@H](NC(=O)C(F)(F)F)CC2=O,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20160130263A1,CS(=O)(=O)Cl.OCc1ccc(COc2ccc(Br)cc2)cc1>>CS(=O)(=O)OCc1ccc(COc2ccc(Br)cc2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090197871A1,COC(=O)c1cccc(C(=O)N(C)Cc2ccc(F)c(-c3cccc(CN4CCN(C)CC4)c3)c2)c1>>CN1CCN(Cc2cccc(-c3cc(CN(C)C(=O)c4cccc(C(=O)O)c4)ccc3F)c2)CC1,,CO,O,Cl,[Li]O,val
US03989737,CCONC(CC)=C1C(=O)CC(C)(C)CC1=O.O=C(Cl)c1ccc(Cl)cc1>>CCON=C(CC)C1=C(OC(=O)c2ccc(Cl)cc2)CC(C)(C)CC1=O,,ClC(Cl)Cl,,,,val
US20060172983A1,COC(=O)CCCCCOc1ccc(NC(=O)CCCCCOCc2ccccc2)cc1>>COC(=O)CCCCCOc1ccc(NC(=O)CCCCCO)cc1,[Pd],CO,,,,val
US20030187020A1,CC(C)(C)OC(=O)N(Cc1cccc(C2CCNCC2)c1)C(=O)OC(C)(C)C.CSc1sc(C(=O)O)c2c1C(=O)CCC2>>CSc1sc(C(=O)N2CCC(c3cccc(CN(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c3)CC2)c2c1C(=O)CCC2,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US05629322,C[C@H]1CC(=O)O[C@@H]1CO[Si](C)(C)C(C)(C)C>>C[C@H]1CC(=O)O[C@@H]1CO,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150274740A1,N=C(N)NNC(=O)c1ccc(Cl)cc1>>Nc1nc(-c2ccc(Cl)cc2)n[nH]1,,c1ccc(Oc2ccccc2)cc1,,,,val
US20040072838A1,CCOC(=O)COc1ccc(SCc2sc(-c3ccc(C(F)(F)F)cc3)nc2CO)cc1C.Cc1nc(-c2cccc(O)c2)no1>>CCOC(=O)COc1ccc(SCc2sc(-c3ccc(C(F)(F)F)cc3)nc2COc2cccc(-c3noc(C)n3)c2)cc1C,,Cc1ccccc1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04853027,CCOC(=O)C(=NO)c1ccccc1[N+](=O)[O-]>>CCOC(=O)c1noc2ccccc12,,COCCOCCOC,,O,[H-].[Na+],val
US04548751,O=C(O)[C@@H](Br)COCc1ccccc1.[N-]=[N+]=C(c1ccccc1)c1ccccc1>>O=C(OC(c1ccccc1)c1ccccc1)[C@@H](Br)COCc1ccccc1,,CC(C)=O,,CC(=O)O,,val
US20140221345A1,CCOC(=O)COc1ccccc1S(C)(=O)=O>>CS(=O)(=O)c1ccccc1OCC(=O)O,,CCO,,[Na+].[OH-],,val
US04709025,CC(=O)Cl.COc1ccc(N2C(=O)[C@H](NC(=O)OC(C)(C)C)[C@@H]2CON2C(=O)c3ccccc3C2=O)cc1>>CC(=O)NOC[C@@H]1NC(=O)[C@@H]1NC(=O)OC(C)(C)C,,CN(C)C=O,ClCCl,c1ccncc1,,val
US20100029753A1,CC(C)c1ccc(S(=O)(=O)Cl)cc1.COC(=O)c1sccc1N>>COC(=O)c1sccc1NS(=O)(=O)c1ccc(C(C)C)cc1,,ClCCl,,c1ccncc1,,val
US20130345419A1,COc1ccc(OCc2nnc([C@@H]3CCCN3C(=O)OC(C)(C)C)o2)cc1OC.Cl>>COc1ccc(OCc2nnc([C@@H]3CCCN3)o2)cc1OC.Cl,,CCOC(C)=O,,,,val
US20090143439A1,CN(C)C=O.Cc1ccsc1CC(C)C.O=S(=O)=O>>Cc1cc(S(N)(=O)=O)sc1CC(C)C,,ClCCl,,O=S(Cl)Cl,,val
US04369325,Cc1cccc(C)c1N1CC(C)N(c2c(C)cccc2C)C1=N.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1cccc(C)c1N1CC(C)N(c2c(C)cccc2C)C1=NC(=O)C(F)(F)F,,c1ccccc1,,,,val
US20050113370A1,CC(C)(C)OC(=O)n1nc(-c2ccccc2)c2ccc(NCC3CC3)cc21.Cl>>Cl.c1ccc(-c2n[nH]c3cc(NCC4CC4)ccc23)cc1,,CCOCC,CO,,,val
US20140194386A1,C=O.COc1c(CC(NC(=O)Cc2ccc3c(c2)CNC3)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)O>>COc1c(CC(NC(=O)Cc2ccc3c(c2)CN(C)C3)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)O,[Pd],CO,,,,val
US20160207928A1,COc1ccc2c(c1)S(=O)(=O)C=C2>>COc1ccc2c(c1)S(=O)(=O)CC2,[Pd],CCO,ClCCl,[H][H],,val
US20100179150A1,C1COCCN1.CCOC(=O)c1sc(Cl)nc1CO[Si](C)(C)C(C)(C)C>>CC(C)(C)[Si](C)(C)OCc1nc(Cl)sc1C(=O)N1CCOCC1,,ClCCl,,C[Al](C)C,Cl,val
US20100160280A1,Clc1nccnc1Cl.O=C(c1ccc(O)cc1)c1ccccn1>>O=C(c1ccc(Oc2nccnc2Cl)cc1)c1ccccn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090018122A1,CC(C)CNc1c(N)c2nnnn2c2ccc(OCc3ccccc3)cc12.CCOCC(=O)Cl>>CCOCc1nc2c(c3cc(OCc4ccccc4)ccc3n3nnnc23)n1CC(C)C,,c1ccncc1,,,,val
US20110021537A1,CCCCOC(=O)N1CCN(C(=O)CNC(=O)c2cc(OCC(=O)OCc3ccccc3)n(-c3ccccc3)n2)CC1>>CCCCOC(=O)N1CCN(C(=O)CNC(=O)c2cc(OCC(=O)O)n(-c3ccccc3)n2)CC1,[Pd],C1CCOC1,,,,val
US20150218096A1,COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C#C[Si](C)(C)C)ccc23)cc1>>C#Cc1ccc2c(-c3ccc(C(=O)OC)cc3)nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160083387A1,C=C1CC[C@H]2[C@H](OC(C)=O)[C@@H]([C@@]3(C)CC[C@H](O[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)C[C@@H]3CCO)CC[C@]12C.Clc1ncccn1>>C=C1CC[C@H]2[C@H](OC(C)=O)[C@@H]([C@@]3(C)CC[C@H](O[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)C[C@@H]3CCOc3ncccn3)CC[C@]12C,,CN(C)C=O,,[H-].[Na+],,val
US20070060510A1,O=S(Cl)Cl.O=c1[nH]c2ccccc2[nH]c1=O>>O=c1[nH]c2ccccc2nc1Cl,,CN(C)C=O,,Cc1ccccc1,,val
US20090062366A1,C[C@H](c1cccc2ccccc12)N(C[C@H]1CNC[C@@H]1c1ccccc1)C(=O)OC(C)(C)C.O=C1CCC(=O)O1>>C[C@H](c1cccc2ccccc12)N(C[C@H]1CN(C(=O)CCC(=O)O)C[C@@H]1c1ccccc1)C(=O)OC(C)(C)C,,C1CCOC1,,CCN(CC)CC,Cl,val
US20090069330A1,CN(C)C(C#N)C1CCC2(CC1)OCCO2.Clc1ccc([Mg]Br)cc1>>CN(C)C(c1ccc(Cl)cc1)C1CCC2(CC1)OCCO2,,CCOCC,,O,[Cl-].[NH4+],val
US20100152168A1,CC(C)(C)OC(=O)C(Cc1ccccc1)n1c(=O)n(C(=O)OC(C)(C)C)c2ccc(Cl)cc21>>O=C(O)C(Cc1ccccc1)n1c(=O)[nH]c2ccc(Cl)cc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US05681966,CC(C)(C)[Si](C)(C)Cl.OC1CCC(c2ccc(F)cc2)O1>>CC(C)(C)[Si](C)(C)OC1CCC(c2ccc(F)cc2)O1,,CN(C)C=O,,O,c1c[nH]cn1,val
US06420365B1,CCOC(=O)c1nc2ccccn2c1Cc1cc(Br)ccc1OC>>COc1ccc(Br)cc1Cc1c(CO)nc2ccccn12,,C1CCOC1,CCCCCC,CC(C)C[Al+]CC(C)C.[H-],,val
US20110059940A1,Cc1ccccc1C(N)C(N)=O.O=S(=O)(Cl)c1ccc(Cl)cc1>>Cc1ccccc1C(NS(=O)(=O)c1ccc(Cl)cc1)C(N)=O,,C1COCCO1,,CCN(CC)CC,,val
US20100099681A1,CC1(C)OB(c2cc3nccnc3cc2Cl)OC1(C)C.COC(=O)c1cc(OC)ccc1Nc1c(Br)c(C)nn1-c1ccccc1C>>COC(=O)c1cc(OC)ccc1Nc1c(-c2cc3nccnc3cc2Cl)c(C)nn1-c1ccccc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20120142672A1,CC(=O)CCl.COc1cc(I)ccc1NC=O>>COc1cc(I)ccc1N(C=O)CC(C)=O,,CN(C)C=O,,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20090062279A1,CC(C)(N)CO.COc1ccc2cc(C#N)cnc2c1>>COc1ccc2cc(C3=NC(C)(C)CO3)cnc2c1,,Clc1ccccc1,,,,val
US20120020950A1,CC1(C)OB(c2ccc(N)c([N+](=O)[O-])c2)OC1(C)C.O=[N+]([O-])c1ccc(Br)cc1F>>Nc1ccc(-c2ccc([N+](=O)[O-])c(F)c2)cc1[N+](=O)[O-],,COCCOC,O,,,val
US20110053916A1,C/C=C\c1cnc(-c2ccc(S(=O)(=O)NC(C)(C)C)s2)nc1Nc1cc(C2CC2)[nH]n1>>C/C=C\c1cnc(-c2ccc(S(N)(=O)=O)s2)nc1Nc1cc(C2CC2)[nH]n1,,ClCCl,,ClB(Cl)Cl,,val
US20110015230A1,CCC(C)Oc1cc(F)ccc1C=CC(=O)OC>>CCC(C)Oc1cc(F)ccc1C=CC(=O)O,,C1CCOC1,CO,[Li+].[OH-],,val
US20160168101A1,N#Cc1ccc(-n2ccnc2)cc1.O=C1CCC(=O)N1Br>>N#Cc1ccc(-n2ccnc2Br)cc1,,C1COCCO1,,,,val
US20080027068A1,CC(C)(C)c1ccc(-c2scc(C=O)c2O)cc1.NNC(=S)Nc1ccc(C(=O)O)cc1>>CC(C)(C)c1ccc(-c2scc(C=NNC(=S)Nc3ccc(C(=O)O)cc3)c2O)cc1,,CN(C)C=O,,Cl,,val
US06265349B1,CS.Cn1c(C(F)(F)F)ccc(-c2c(F)cc(Cl)c3oc(CBr)cc23)c1=O>>CSCc1cc2c(-c3ccc(C(F)(F)F)n(C)c3=O)c(F)cc(Cl)c2o1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20100261724A1,C[C@@H](NC(=O)Cc1ccc(O)cc1)c1ccc(NCC(F)(F)F)cn1.OC1CCOC1>>C[C@@H](NC(=O)Cc1ccc(OC2CCOC2)cc1)c1ccc(NCC(F)(F)F)cn1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100292188A1,CC(=O)Oc1ccc(-c2nc3c(s2)CN(C(C)=O)CC3)c(F)c1>>CC(=O)N1CCc2nc(-c3ccc(O)cc3F)sc2C1,,CO,,[Na],,val
US20050004162A1,II.OCCc1coc2ccc(Cl)cc12>>Clc1ccc2occ(CCI)c2c1,,C1CCOC1,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070203155A1,BrBr.CCCc1ccc(-c2cnc(C)s2)cc1>>CCCc1ccc(-c2sc(C)nc2Br)cc1,,ClC(Cl)Cl,ClCCl,,,val
US08680122B2,C[Si](C)(C)Cl.Nc1ccc(C(=O)O)cn1>>C[Si](C)(C)C(=O)c1ccc(N)nc1,,ClCCl,c1ccncc1,,,val
US20060009453A1,CN(C)C1CCNC1.CNc1cc(-c2cccnc2Oc2ccc(Cl)c(NC(=O)c3cc(C(F)(F)F)ccc3F)c2)ccn1>>CNc1cc(-c2cccnc2Oc2ccc(Cl)c(NC(=O)c3cc(C(F)(F)F)ccc3N3CCC(N(C)C)C3)c2)ccn1,,CS(C)=O,,,,val
US20060063767A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(O)c1cccc(Cc2n[nH]c(=O)c3ccccc23)n1>>O=C(c1cccc(Cc2n[nH]c(=O)c3ccccc23)n1)N1CCNCC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090233952A1,Br[Mg]CCC1OCCCO1.C1CCOC1.C1CCOC1.O=C1CCCO1>>OCCCCC(O)(CCC1OCCCO1)CCC1OCCCO1,,C1CCOC1,,[Cl-].[NH4+],,val
US20120040985A1,CC(C)(C)OC(=O)N=C(N)NC(=O)OC(C)(C)C.COC(=O)c1cc(CSc2ncc(C(C)(C)c3ccc(Cl)c(Cl)c3)n2-c2ccc(F)c(OC)c2)ccc1CCCO>>COC(=O)c1cc(CSc2ncc(C(C)(C)c3ccc(Cl)c(Cl)c3)n2-c2ccc(F)c(OC)c2)ccc1CCCNC(=N)N,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110003787A1,COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(C3=NC[C@H](C)O3)[nH]2)c1>>C[C@H]1CN=C(c2ccc(-c3cc(Oc4ccc(S(C)(=O)=O)cc4)cc(O[C@@H](C)CO)c3)[nH]2)O1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20120295884A1,CN1CCN(c2cc(Cl)c(F)c(CNC(=O)OC(C)(C)C)c2)CC1>>CN1CCN(c2cc(Cl)c(F)c(CN)c2)CC1,,C1COCCO1,,Cl,,val
US20140221335A1,CN.N#Cc1ccc(C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)CC3)c(F)c1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1F,CN(C)c1ccncc1,CC#N,,CCN(C(C)C)C(C)C,,val
US20120040954A1,CC(=O)N1C(C)CN(c2ccc(-c3nc4cc(F)cc(F)c4c(=O)[nH]3)cc2)CC1C.CO>>COc1cc(F)cc2nc(-c3ccc(N4CC(C)N(C(C)=O)C(C)C4)cc3)[nH]c(=O)c12,,CC(=O)O,CN(C)C=O,O,C[O-].[Na+],val
US05380724,N#CCc1ccc(N)cc1.O=C(Cl)CCl>>N#CCc1ccc(NC(=O)CCl)cc1,,CC(=O)N(C)C,,O,,val
US20020111358A1,CCOC(=O)c1cc2c(O)cccc2[nH]1.O=[N+]([O-])c1ccc(S(=O)(=O)OC[C@@H]2CO2)cc1>>CCOC(=O)c1cc2c(OC[C@@H]3CO3)cccc2[nH]1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04965403,CCN(CCO)CP(=O)(O)O.O>>O=C(O)CNCP(=O)(O)O,,Cl,,,,val
US20120029190A1,[N-]=[N+]=NC1CCN(C(=O)OCc2ccccc2)CC1N=[N+]=[N-]>>NC1CCN(C(=O)OCc2ccccc2)CC1N,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150223460A1,Cc1cc(-c2ccn(C)n2)ccc1O.Cn1nnn(-c2cccc(C3CC3)c2CBr)c1=O>>Cc1cc(-c2ccn(C)n2)ccc1OCc1c(C2CC2)cccc1-n1nnn(C)c1=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050049262A1,CC(=O)O[C@H](C)CCCCCl.Cn1c(=O)[nH]c(=O)c2c1ncn2Cc1ccccc1>>CC(=O)O[C@H](C)CCCCn1c(=O)c2c(ncn2Cc2ccccc2)n(C)c1=O,,CS(C)=O,,[H-].[Na+],,val
US20140057305A1,CC(C)(C)OC(=O)N1CCN(CCOCCO)C(CNC(=O)C(F)(F)F)C1>>O=C(NCC1CNCCN1CCOCCO)C(F)(F)F,,Cl,,,,val
US20070099944A1,COCC(=O)CC(=O)OC.NC(N)=O.O=Cc1ccc(F)cc1>>COCC1=C(C(=O)OC)C(c2ccc(F)cc2)NC(=O)N1,,Cc1ccccc1,O,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US20040006083A1,COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1NC(=O)c1cc2ccccc2n1C.Nc1ncnc2c1c(I)nn2C1CCNC1>>COc1cc(-c2nn(C3CCNC3)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20060135552A1,CC(=O)CC(C)=O.COc1ccc(C(=O)c2c(N)sc3c2CCCC3)cc1>>COc1ccc(-c2c(C(C)=O)c(C)nc3sc4c(c23)CCCC4)cc1,O=S(=O)(O)O,CC(=O)O,,,,val
US20130030012A1,O=[N+]([O-])c1ccc(Br)cn1.Oc1ccc(Cl)c(C(F)(F)F)c1>>O=[N+]([O-])c1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)cn1,,CC#N,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20040002485A1,O=C(O)c1ccc(Cc2ccc(F)cc2)o1.O=S(Cl)Cl>>O=C(Cl)c1ccc(Cc2ccc(F)cc2)o1,,CN(C)C=O,,,,val
US20060205767A1,COc1ccc(-c2cc(=O)c3ccccc3s2)cc1>>O=c1cc(-c2ccc(O)cc2)sc2ccccc12,,ClCCl,,BrB(Br)Br,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC3(CC2)OCCO3)c2nc(C(F)(F)F)nn12>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC(O)CC2)c2nc(C(F)(F)F)nn12,,C1CCOC1,,Cl,[Na+].[OH-],val
US20040063712A1,CCOC(=O)c1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1CO>>CCOC(=O)c1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1C=O,O=[Mn]=O,ClC(Cl)Cl,,,,val
US20120070410A1,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCCl)ccc34)cc2)no1.NCCO>>CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCNCCO)ccc34)cc2)no1,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20130116248A1,CC(=O)Nc1cc(C)c(Br)cn1.Cn1c(=NC#N)n(-c2ccc(C(C)(C)C#N)nc2)c2c3cc(B(O)O)ccc3ncc21>>CC(=O)Nc1cc(C)c(-c2ccc3ncc4c(c3c2)n(-c2ccc(C(C)(C)C#N)nc2)c(=NC#N)n4C)cn1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20050004119A1,C[C@@H](C(=O)OC(C)(C)C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O>>C[C@@H](C(=O)O)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030032800A1,COC1=Cc2ccccc2Nc2ccccc21.N#CO[Na]>>COC1=Cc2ccccc2N(C(N)=O)c2ccccc21,,CC(=O)O,,,,val
US20040106599A1,COC(=O)c1ccc(C=O)cc1.O=C1CCOc2ccccc21>>COC(=O)c1ccc(C=C2COc3ccccc3C2=O)cc1,,CC(=O)O,,O=S(=O)(O)O,,val
US20100016387A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cccc(C)c1-c1nc2ccc(C=O)cc2[nH]1>>Cc1cccc(C)c1-c1nc2ccc(C=O)cc2n1C(=O)OC(C)(C)C,CN(C)c1ccncc1,C1CCOC1,,,,val
US20140296245A1,COc1ccc(CN)c(OC)c1.O=C(CCl)Nc1ccc(Cl)cc1>>COc1ccc(CNCC(=O)Nc2ccc(Cl)cc2)c(OC)c1,,C1CCOC1,,,,val
US20020103230A1,N#Cc1cn[nH]c1NC(=O)Cc1nc2ccccc2[nH]1>>Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2[nH]ncc12,,O,,C[O-].[Na+],,val
US20030195199A1,CCCCCCCCOC(=O)Nc1scc(C)c1C(=O)OCC>>CCCCCCCCOC(=O)Nc1scc(C)c1C(=O)O,,C1CCOC1,CCO,O,[Li]O,val
US05157038,C=C1N(C)C(=O)OC12CCNCC2.CCCCN=C=O>>C=C1N(C)C(=O)OC12CCN(C(=O)NCCCC)CC2,,CC#N,,,,val
US20120172351A1,Cc1nc(N2CCOCC2)nc(C)c1-c1cccc(CNc2ccc3c(c2)OC[C@H]3CC(=O)O)c1C.NC(CO)(CO)CO>>Cc1nc(N2CCOCC2)nc(C)c1-c1cccc(CNc2ccc3c(c2)OC[C@H]3CC(=O)[O-])c1C.[NH3+]C(CO)(CO)CO,,CO,,,,val
US20120165310A1,CC(C)(N)CS.CCOC(=O)CBr>>CC1(C)CSCC(=O)N1,,CCO,,Cl,[K+].[OH-],val
US20090181928A1,CCC(=O)CC.O=[N+]([O-])c1ccc(CBr)cc1OCc1ccccc1>>CCC(=O)C(C)Cc1ccc([N+](=O)[O-])c(OCc2ccccc2)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100069347A1,CC(=O)OCC(O)(C#Cc1ccc([C@@H]2[C@@H](CC[C@H](O)c3ccc(F)cc3)C(=O)N2c2ccc(OS(=O)(=O)C(F)(F)F)cc2)cc1)COC(C)=O>>CC(=O)OCC(O)(C#Cc1ccc([C@@H]2[C@@H](CCC(=O)c3ccc(F)cc3)C(=O)N2c2ccc(OS(=O)(=O)C(F)(F)F)cc2)cc1)COC(C)=O,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05576321,Cc1cccc2c(C3=CCNCC3)c[nH]c12.ClCCCOc1cccc2[nH]ccc12>>Cc1cccc2c(C3=CCN(CCCOc4cccc5[nH]ccc45)CC3)c[nH]c12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05134152,C=C[C@H](C)[C@](O)(Cn1cncn1)c1ccc(F)cc1F.O=C(OO)c1cccc(Cl)c1>>C[C@@H]([C@H]1CO1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F,,CCOC(C)=O,ClCCl,,,val
US04999377,Oc1ccc(CCNCc2ccccc2)cc1.c1ccc(OCC2CO2)cc1>>Oc1ccc(CCN(Cc2ccccc2)CC(O)COc2ccccc2)cc1,,CC(C)O,,CCN(CC)CC,Cl,val
US20070054935A1,Clc1cc(Cl)cc([Mg]Br)c1.N#Cc1cccc(-c2ccncc2C=O)c1>>N#Cc1cccc(-c2ccncc2C(O)c2cc(Cl)cc(Cl)c2)c1,,C1CCOC1,,,,val
US20120059014A1,CC(C)c1noc(N2CCC(CCCOc3cnc(N4C[C@H](NC(=O)OC(C)(C)C)[C@@H](N5CCCCC5=O)C4)nc3)CC2)n1>>CC(C)c1noc(N2CCC(CCCOc3cnc(N4C[C@H](N)[C@@H](N5CCCCC5=O)C4)nc3)CC2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130281490A1,CC(C)(C)[C@H](O)[C@@H](NC(=O)OCCCCCc1ccccc1)C(=O)O>>CC(C)(C)[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20060052238A1,CC(C)(C)OCCCCCCCl.[SiH3]C(Cl)(Cl)Cl>>CC(C)(C)OCCCCCC[SiH2]C(Cl)Cl,,CCOCC,,,,val
US05866573,CC(C[N+](=O)[O-])c1cccnc1>>CC(CN)c1cccnc1,[Pd],CCO,Cl,,,val
US20050222124A1,Nc1ccc2c(c1)CCN(C(=O)C(F)(F)F)CC2.O=S(=O)(Cl)c1ccc(-c2ccc(Cl)cc2)cc1>>O=C(N1CCc2ccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)cc4)cc3)cc2CC1)C(F)(F)F,,ClCCl,c1ccncc1,,,val
US20160218303A1,N#Cc1cccc(Nc2cccc(-c3ccccc3)c2)c1[N+](=O)[O-]>>N#Cc1cccc(Nc2cccc(-c3ccccc3)c2)c1N,,CCO,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20090069400A1,COC(=O)c1cc(C)c(Br)s1.Cc1cc(C#N)sc1Br.Cc1cc(C(N)=O)sc1Br.N>>NC(=O)c1ncc(Br)cc1N,,CO,,O=P(Cl)(Cl)Cl,,val
US20120115846A1,COc1ccc(Cn2c(=O)c3cc(OCc4ccccc4)ccc3n(C3CCSCC3)c2=O)cc1OC>>COc1ccc(Cn2c(=O)c3cc(O)ccc3n(C3CCSCC3)c2=O)cc1OC,,CCOC(C)=O,,O=CO,,val
US20100048562A1,O=C1CCCc2c(F)cc(Br)cc21>>OC1CCCc2c(F)cc(Br)cc21,,CO,ClCCl,O,[BH4-].[Na+],val
US20140364432A1,Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ncc3c(Br)cccc3n2)c1>>Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ncc3ccccc3n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C[O-].[NH4+],,val
US20140142083A1,CC(C)(C)OC(=O)NCC=O.COC(=O)c1cc(Cl)cc(N)c1C>>COC(=O)c1cc(Cl)cc(NCCNC(=O)OC(C)(C)C)c1C,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20070037796A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=[N+]([O-])c1ccc(CCCNCCNS(=O)(=O)c2cc(Br)cc3cnccc23)cc1>>CC(C)(C)OC(=O)N(CCCc1ccc([N+](=O)[O-])cc1)CCNS(=O)(=O)c1cc(Br)cc2cnccc12,,ClCCl,,,,val
US20060211720A1,CC(C)(O)c1cc(Br)ccc1CO>>CC1(C)OCc2ccc(Br)cc21,,C1COCCO1,O,O=S(=O)(O)O,,val
US20110301167A1,CI.CO.O=c1c2nn(Cc3ccc(-n4cccn4)cc3)c3ccccc3c-2nn1CC(O)CO>>COCC(Cn1nc2c3ccccc3n(Cc3ccc(-n4cccn4)cc3)nc-2c1=O)OC,,O,,CN(C)C=O,[H-].[Na+],val
US06166219,CCOC(=O)c1ccc([N+](=O)[O-])c(NC(C)=O)c1.Clc1ccccc1CBr>>CCOC(=O)c1ccc([N+](=O)[O-])c(NC(=O)CCc2ccccc2Cl)c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20080269196A1,CC(C)CCNc1nc(-c2ccc(CN)cc2)cs1.O=C(N1CCc2ccc(Cl)c(OS(=O)(=O)C(F)(F)F)c2CC1)C(F)(F)F>>CC(C)CCNc1nc(-c2ccc(CNc3c(Cl)ccc4c3CCN(C(=O)C(F)(F)F)CC4)cc2)cs1,,Cc1ccccc1,,,,val
US20090286825A1,COC(=O)C(=O)c1c2n(c3ccccc13)CC(N(C)S(=O)(=O)c1ccc(F)cc1)CC2>>COC(=O)Cc1c2n(c3ccccc13)CC(N(C)S(=O)(=O)c1ccc(F)cc1)CC2,,C1CCOC1,CO,CC(=O)O,[BH4-].[Na+],val
US05066658,CCCCCCCCCCNOCc1ccccc1.CN=C=O>>CCCCCCCCCCN(OCc1ccccc1)C(=O)NC,,ClCCl,,,,val
US20100137336A1,CC(C)C(=O)Cl.O=[N+]([O-])c1ccc(N2CCNCC2)c(Cl)c1>>CC(C)C(=O)N1CCN(c2ccc([N+](=O)[O-])cc2Cl)CC1,,ClCCl,,CCN(CC)CC,,val
US20120295884A1,CC(C)(C)OC(=O)NCc1cc(C=O)cc(Cl)c1F.CNCCOC>>COCCN(C)Cc1cc(Cl)c(F)c(CNC(=O)OC(C)(C)C)c1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US06956049B1,NC(N)=S.O=C(C#Cc1ccccc1)CCl>>Nc1nc(C#Cc2ccccc2)cs1,,CCOC(C)=O,CN(C)C=O,CCCCCC,,val
US20100292241A1,CNCc1ccc(C(C)(C)C)cc1.O=C1OC(CBr)CN1c1ccccc1>>CN(Cc1ccc(C(C)(C)C)cc1)CC1CN(c2ccccc2)C(=O)O1,,C1CCOC1,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140323468A1,ClCCCI.Fc1cc(Cl)ccn1>>Fc1nccc(Cl)c1CCCCl,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20110105463A1,CC(C)(C)Oc1ccccc1C=C[N+](=O)[O-]>>CC(C)(C)Oc1ccccc1CCN,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04514391,C=[N+]=[N-].C[C@H](NC(=O)OC(C)(C)C)C(=O)O>>C[C@H](NC(=O)OC(C)(C)C)C(=O)C=[N+]=[N-],,C1CCOC1,CCOCC,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20150158851A1,CCOC(=O)C1(C(=O)OC)CCC2(CC1)OCCO2>>OCC1(CO)CCC2(CC1)OCCO2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040132963A1,CC(C)(C)Cl.CCCCCC.S=C=S.c1ccc2c(c1)Cc1ccccc1-2>>CC(C)(C)c1ccc2c(c1)Cc1cc(C(C)(C)C)ccc1-2,,CCCCCC,,O,,val
US20150080549A1,CC(C)(C)OC(=O)OC(=O)[O-].CC(C)(C)SSCCN.CCOC(=O)CBr>>CCOC(=O)CN(CCSSC(C)(C)C)C(=O)OC(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05798375,COc1ccc([N+](=O)[O-])c(N(C)C(=O)OC(C)(C)C)c1>>CNc1cc(OC)ccc1[N+](=O)[O-],,C1COCCO1,,Cl,,val
US20040138223A1,COc1ccc2c(c1)C(C(=O)N(Cc1ccc([N+](=O)[O-])cc1)c1ccc(C(C)C)cc1)CCC2>>COc1ccc2c(c1)C(C(=O)N(Cc1ccc(N)cc1)c1ccc(C(C)C)cc1)CCC2,,CCO,,Cl,,val
US05030654,CC(=O)NCCCCC(CC1(C(=O)N[C@H]2CC[C@@H](C(=O)O)CC2)CCCC1)C(=O)OC(C)(C)C>>CC(=O)NCCCCC(CC1(C(=O)N[C@H]2CC[C@@H](C(=O)O)CC2)CCCC1)C(=O)O,,O=C(O)C(F)(F)F,,,,val
US07405302B2,COc1cnc2c(c1)cc(/C=C/C(=O)O)n2Cc1ccc(Cl)cc1.O>>COc1cnc2c(c1)cc(CO)n2Cc1ccc(Cl)cc1,,C1CCOC1,,,,val
US05753679,O=C(Cl)c1ccccc1.OC1CCN(Cc2cccc(Br)c2)CC1>>O=C(OC1CCN(Cc2cccc(Br)c2)CC1)c1ccccc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20100234340A1,COC(=O)c1ncn2c1CN(S(=O)(=O)c1c(C)cc(OC)cc1C)CC2>>COc1cc(C)c(S(=O)(=O)N2CCn3cnc(C(=O)O)c3C2)c(C)c1,,CO,O,[Li+].[OH-],,val
US20100137281A1,COc1ccc(Cn2c(=O)c3cc(CC(F)(F)F)sc3n(Cc3ccc(-c4ccccc4C#N)cc3)c2=O)c(OC)c1>>N#Cc1ccccc1-c1ccc(Cn2c(=O)[nH]c(=O)c3cc(CC(F)(F)F)sc32)cc1,,Cc1ccccc1,,O=C(O)C(F)(F)F,,val
US20020099209A1,COc1cccc(C=O)c1.O=C(O)Cc1ccccc1>>COc1cccc(C=CC(=O)O)c1-c1ccccc1,,CC(=O)OC(C)=O,,CCN(CC)CC,O,val
US20110178132A1,COc1ccc(C(F)(F)F)c(-c2ccncc2)c1.O=C(OO)c1cccc(Cl)c1>>COc1ccc(C(F)(F)F)c(-c2cc[n+]([O-])cc2)c1,,ClC(Cl)Cl,,O=S([O-])[O-].[Na+].[Na+],,val
US20120295934A1,O=C1C2CN(Cc3ccccc3)CC2C(=O)N1c1ccc(OC(F)(F)F)cc1>>O=C1C2CN(Cc3ccccc3)CC2C(O)N1c1ccc(OC(F)(F)F)cc1,,CCO,ClCCl,O,[BH4-].[Na+],val
US20030078251A1,CC(=O)Cl.COc1cccc([C@H]2O[C@H](CC(=O)NCCc3ccc(OC(C)(C)C(=O)O)cc3)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC>>COc1cccc([C@H]2O[C@H](CC(=O)NCCc3ccc(OC(C)(C)C(=O)O)cc3)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC,,O,,CCOC(C)=O,c1ccncc1,val
US20100286114A1,O=C1CCN(c2ccc(Cl)c(-c3nc4ccccc4[nH]3)c2)CC1>>OC1CCN(c2ccc(Cl)c(-c3nc4ccccc4[nH]3)c2)CC1,,CO,,[BH4-].[Na+],,val
US06759509B1,Cl.NCCN(C(=O)OCc1ccccc1)C(=O)OCc1ccccc1>>Cl.NCCNC(=O)OCc1ccccc1,,CC(=O)O,,,,val
USRE039198E1,CC(=O)c1ccc(OCCCCl)c(O)c1.Fc1ccc2c(C3CCNCC3)noc2c1>>CC(=O)c1ccc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)c(O)c1,,O,,CC#N,,val
US20080161305A1,COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)O)CC4)cc3)c2cc1OC.NCc1ccc(F)cc1>>COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)NCc5ccc(F)cc5)CC4)cc3)c2cc1OC,,CC(=O)N(C)C,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04859691,O=C(O)C(Br)c1noc2ccccc12>>BrCc1noc2ccccc12,,Cc1ccccc1,,,,val
US05198450,Cl.N#CN.Nc1ccc(CCCC(=O)N2CCSC2)cc1>>Cl.N=C(N)Nc1ccc(CCCC(=O)N2CCSC2)cc1,,CCO,,,,val
US20040077669A1,CC#CCO.CCN(c1cccc(F)c1)c1cc(Cl)ncn1>>CC#CCOc1cc(N(CC)c2cccc(F)c2)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US08431695B2,CC1(C)C(=O)N(Br)C(=O)N1Br.Nc1ncnn2c([C@@H]3CCCN(C(=O)OCc4ccccc4)C3)ccc12>>Nc1ncnn2c([C@@H]3CCCN(C(=O)OCc4ccccc4)C3)cc(Br)c12,,CN(C)C=O,,,,val
US20080161289A1,N.O=C(O)c1ccc(N2CCC(c3nc4c(s3)CCN(C3CCC3)CC4)CC2)cn1>>NC(=O)c1ccc(N2CCC(c3nc4c(s3)CCN(C3CCC3)CC4)CC2)cn1,,CN(C)C=O,CO,On1nnc2ccccc21,,val
US20150110809A1,Cc1cc(C)cc(C)c1.O=S(=O)(Cl)c1ccc(I)cc1>>Cc1cc(C)c(S(=O)(=O)c2ccc(I)cc2)c(C)c1,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US05187175,CON(C)C(=O)c1nc(C(C)(C)C)c(O)c(C(C)(C)C)n1.C[Si](C)(C)C#CCCC[Mg]Br>>CC(C)(C)c1nc(C(=O)CCCC#C[Si](C)(C)C)nc(C(C)(C)C)c1O,,C1CCOC1,,,,val
US20090156612A1,Brc1ccccn1.COC[C@]1(O)CCCC[C@H]1n1cnc(C(=O)N2CCN(C(=O)OC(C)(C)C)C[C@H]2CCO)c1-c1ccccc1>>COC[C@]1(O)CCCC[C@H]1n1cnc(C(=O)N2CCN(C(=O)OC(C)(C)C)C[C@H]2CCOc2ccccn2)c1-c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20090281140A1,COc1cccc(NC(=O)OC(C)(C)C)c1C>>COc1cccc(N)c1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US04048198,CCCCCC(=O)C=CC1CCC(CCCCCCCC(=O)OC)O1>>CCCCCC(=O)CCC1CCC(CCCCCCCC(=O)OC)O1,[Ni],CO,,,,val
US20160024110A1,CCOC(=O)C(=O)OCC.COc1cc(Br)c(F)cc1F>>CCOC(=O)C(=O)c1cc(OC)c(F)cc1F,,C1CCOC1,O,[Mg],[Cl-].[NH4+],val
US20100227866A1,COc1ccc(CC(C(=O)[O-])c2cccc(CCNC(=O)C3c4ccccc4C(=O)N(C4CCCCC4O)C3c3ccc(Cl)cc3Cl)c2)cc1>>O=C(O)Cc1cccc(CCNC(=O)C2c3ccccc3C(=O)N(C3CCCCC3O)C2c2ccc(Cl)cc2Cl)c1,,ClCCCl,,O=C(O)C(F)(F)F,,val
US06083943,C[C@@H]1[C@H](COCc2ccccc2)[C@H](NC(=O)OC(C)(C)C)[C@H](c2ccccc2)N1C(=O)OCc1ccccc1.O=C=O>>COC(=O)[C@H]1C[C@H](N)[C@H](c2ccccc2)N(C(=O)OCc2ccccc2)C1,,Cl,,CO,,val
US20080207633A1,C1CNCCN1.CN1CCC(C(Cl)c2ccc(F)cc2)CC1>>CN1CCC(C(c2ccc(F)cc2)N2CCNCC2)CC1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090298836A1,CC(C)(C)OC(=O)N[C@H](CCC(=O)NNC(=O)c1ccc([N+](=O)[O-])c(F)c1)Cc1ccc(C(F)(F)F)nc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)(C)OC(=O)N[C@H](CCc1nnc(-c2ccc([N+](=O)[O-])c(F)c2)s1)Cc1ccc(C(F)(F)F)nc1,,C1CCOC1,,,,val
US20110144345A1,CB1OB(C)OB(C)O1.Cn1ncc(C(=O)c2ccc(Br)c(N=C3CCCCS3=O)c2Cl)c1OCc1ccc2ccccc2c1>>Cc1ccc(C(=O)c2cnn(C)c2O)c(Cl)c1N=C1CCCCS1=O,,CCOC(C)=O,O,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20080221192A1,CN1CCN(Cc2ccc(C(=O)Nc3cccc(Nc4ccc5c(c4)CC(=O)N5)c3)cc2)CC1.O=Cc1ccc[nH]1>>CN1CCN(Cc2ccc(C(=O)Nc3cccc(Nc4ccc5c(c4)C(=Cc4ccc[nH]4)C(=O)N5)c3)cc2)CC1,C1CCNCC1,CCO,,,,val
US04994571,N.O=S(=O)(Cl)c1c(Cl)nc2ccccn12>>NS(=O)(=O)c1c(Cl)nc2ccccn12,,CC#N,,,,val
US20040220179A1,CC(c1ccc(Cl)cc1[N+](=O)[O-])N1C(=O)c2cc(I)ccc2N(CCCCC(=O)OC(C)(C)C)C(=O)C1c1ccc(Cl)cc1>>CC(c1ccc(Cl)cc1N)N1C(=O)c2cc(I)ccc2N(CCCCC(=O)OC(C)(C)C)C(=O)C1c1ccc(Cl)cc1,[Fe],CCO,O,[Cl-].[NH4+],,val
US05041513,CC(C)(c1ccc(Oc2ccc(N)cc2)cc1)c1ccc(Oc2ccc(N)cc2)cc1.CN1CCCC1=O.C[Si](C)(CCCN)CC[Si](C)(C)CCCN.O.O=C1OC(=O)c2cc(-c3ccc4c(c3)C(=O)OC4=O)ccc21>>CC1(C)CC(C)(c2ccc(N)cc2)c2ccc(N)cc21.O=C(c1ccc2c(c1)C(=O)OC2=O)c1ccc2c(c1)C(=O)OC2=O,,Cc1ccccc1C,,,,val
US20030008896A1,COc1ccc(CC(=O)Cl)cc1.O=C(O)Cc1ccccc1C(=O)O>>COc1ccc(Cc2cc3ccccc3c(=O)o2)cc1,,Cc1ccccc1,,,,val
US20140228361A1,O=C1OCCC2CN(Cc3ccccc3)CC12>>OCCC1CN(Cc2ccccc2)CC1CO,,C1CCOC1,,[BH4-].[Li+],,val
US20150080367A1,CC(C)(C)OC(=O)N1CCC(c2cc(Cl)nc(Cl)c2)CC1.FC1(F)C=CC=NC1>>CC(C)(C)OC(=O)N1CCC(c2cc(Cl)nc(N3CCC(F)(F)C3)c2)CC1,,CCOC(C)=O,CN1CCCC1=O,CCN(C(C)C)C(C)C,Cl,val
US04358620,CC(=O)OC(C)=O.NCC12CC(c3ccccc31)c1ccccc12>>CC(=O)C12CC(c3ccccc31)c1cccc(CN)c12,,O,,CCO,,val
US05665598,CC(=O)OC(C)=O.COC(=O)C(O)NC(=O)OC(C)(C)C>>COC(=O)C(NC(=O)OC(C)(C)C)OC(C)=O,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,c1ccncc1,,val
US20110021434A1,C=CCCOc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)OC)cc1>>C=CCCOc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc1,,C1CCOC1,O,CO,[Na+].[OH-],val
US20160108056A1,COC(=O)c1cc2ccc(N)cc2s1.CS(=O)(=O)Cl>>COC(=O)c1cc2ccc(NS(C)(=O)=O)cc2s1,,c1ccncc1,,,,val
US06420507B1,CC1=C(C)C(N(C2CCCCC2)[SiH](C)C)c2cc(C)cc(C)c21.CC1=Cc2cc3c(cc2C1[Si](C)(C)Cl)CCC3>>CC1=Cc2cc3c(cc2C1[Si](C)(C)NC1CCCCC1)CCC3,,CCCCCC,,CCN(CC)CC,,val
US20140088078A1,CCN1CCC[C@H]1C(=O)OCc1ccccc1>>CCN1CCC[C@H]1C(=O)O,[Pd],,,,,val
US20120108597A1,CC[C@H](N)C(=O)OC(C)(C)C.Nc1cccnc1C(=O)O>>CC[C@H](NC(=O)c1ncccc1N)C(=O)OC(C)(C)C,,O,c1ccncc1,Cl,O=C(n1ccnc1)n1ccnc1,val
US20090163592A1,COc1cccc(C(=O)NN)c1C.O=CC1CCCCC1>>COc1cccc(C(=O)NN=CC2CCCCC2)c1C,,CCO,,CC(=O)O,,val
US20100004235A1,CCI.COc1ccc(Cn2c(-c3nn(Cc4ccccc4F)c4ncccc34)n[nH]c2=O)c(OC)c1>>CCn1nc(-c2nn(Cc3ccccc3F)c3ncccc23)n(Cc2ccc(OC)cc2OC)c1=O,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150361059A1,C[C@H]1Oc2ccccc2NC(=O)[C@H]1NC(=O)OC(C)(C)C>>C[C@H]1Oc2ccccc2NC(=O)[C@H]1N,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160096804A1,COC(=O)c1ccc(CN(c2nc(C)ns2)c2nc(C)ns2)cc1F.NO>>Cc1nsc(N(Cc2ccc(C(=O)NO)c(F)c2)c2nc(C)ns2)n1,,CO,,,,val
US04136192,CCCc1c(OCC(O)COc2ccc3c(O)cc(=O)oc3c2)ccc(C(C)=O)c1O.O=[N+]([O-])O>>CCCc1c(OCC(O)COc2ccc3c(O)c([N+](=O)[O-])c(=O)oc3c2)ccc(C(C)=O)c1O,,ClC(Cl)Cl,,Cl,,val
US05157041,N#CC[C@H](N)C(=O)O.O=C(Cl)c1ccc2ccccc2c1>>N#CC[C@H](NC(=O)c1ccc2ccccc2c1)C(=O)O,,[Na+],[OH-],,,val
US20070135594A1,BrBr.Cc1ccc(N)c(C)c1>>Cc1cc(C)c(N)c(Br)c1,,CC(=O)O,,,,val
US20150274661A1,CCOC(=O)c1cc2cc(C(C)N3CCCC3)ccc2[nH]1>>CC(c1ccc2[nH]c(C(=O)O)cc2c1)N1CCCC1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20100249110A1,CCOC(=O)CCN(c1ccccc1)c1nc(SC)nc(Cl)c1C(=O)OCC>>CCOC(=O)C1CN(c2ccccc2)c2nc(SC)nc(Cl)c2C1=O,,C1CCOC1,,O,CC(C)[N-]C(C)C.[Li+],val
US06956050B2,CCc1nc(-c2ccccc2)cn1-c1ccc(CCOC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1.Cc1ccc(S(=O)(=O)O)cc1>>CCc1nc(-c2ccccc2)cn1-c1ccc(CCOC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1.Cc1ccc(S(=O)(=O)O)cc1,,CC(C)=O,,,,val
US04025547,C=CCO.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C=CCOC(=O)CC=C,Cl[Pd]Cl,,,Cl[Sn]Cl,,val
US20100305067A1,ClCCN1CCOCC1.Oc1cc(Br)ccn1>>O=c1cc(Br)ccn1CCN1CCOCC1,,CS(C)=O,,O,[K+].[OH-],val
US20110136809A1,COCCN.O=S(=O)(Cl)c1cccc(Br)c1>>COCCNS(=O)(=O)c1cccc(Br)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120283219A1,COC(=O)COc1cccc(N(C)C(=O)OC(C)(C)C)c1>>CN(C(=O)OC(C)(C)C)c1cccc(OCC(=O)O)c1,,C1CCOC1,O,[Li+].[OH-],,val
US04977154,C1CNCCN1.Nc1c(F)c(F)c(Cl)c2c1c(=O)c(C(=O)O)cn2C1CC1>>Nc1c(F)c(N2CCNCC2)c(Cl)c2c1c(=O)c(C(=O)O)cn2C1CC1,,CC#N,,,,val
US04794183,ClCc1ccccc1.OCC1=CCCCO1>>C1=C(COCc2ccccc2)OCCC1,,CN(C)C=O,,O,[H-].[Na+],val
US20120316161A1,CCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc2occc2c1>>CCCC(C(=O)O)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc2occc2c1,,CO,O,[Na+].[OH-],,val
US20060276475A1,CNCCN(C)c1nc(N)n2nc(-c3ccco3)nc2n1.Cc1cc(CCl)no1>>Cc1cc(CN(C)CCN(C)c2nc(N)n3nc(-c4ccco4)nc3n2)no1,,CC#N,,CCN(CC)CC,,val
US20140275179A1,COc1cccc(C(F)(F)F)c1CO.O=S(Cl)Cl>>COc1cccc(C(F)(F)F)c1CCl,,ClC(Cl)Cl,,,,val
US20140336177A1,C[C@@H]1Cc2cc([C@@H]3CN4CCN(C(=O)OCc5ccccc5)C[C@H]4CN3C(=O)OC(C)(C)C)ccc2C(=O)O1>>C[C@@H]1Cc2cc([C@@H]3CN4CCNC[C@H]4CN3C(=O)OC(C)(C)C)ccc2C(=O)O1,[Pd],CO,,,,val
US06229011B1,COC(=O)[C@@H](N)Cc1ccccc1>>N[C@@H](Cc1ccccc1)C(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20100197591A1,COC(=O)Cc1ccc(Br)cc1.ICCCCI>>COC(=O)C1(c2ccc(Br)cc2)CCCC1,,C1CCOC1,,CCOC(C)=O,[H-].[Na+],val
US20050070542A1,BrBr.Oc1cccc(OC(F)(F)F)c1>>Oc1cc(OC(F)(F)F)ccc1Br,,ClCCl,,,,val
US20080004300A1,CC1(C)C(=O)N(c2ccc(OC(F)(F)F)c([N+](=O)[O-])c2)C(=O)N1Cc1ccncc1>>CC1(C)C(=O)N(c2ccc(OC(F)(F)F)c(N)c2)C(=O)N1Cc1ccncc1,[Zn],O,,Cl,,val
US03952104,C1CCNCC1.C=CCc1ccc(OCCC(C)C)c2c(=O)cc(C(=O)O)oc12>>C1CCNCC1.C=CCc1ccc(OCCC(C)C)c2c(=O)cc(C(=O)O)oc12,,CCO,,,,val
US20110195954A1,Cc1cncc2ccccc12.Cl>>CC1CNCc2ccccc21.Cl,O=[Pt]=O,CO,,[H][H],,val
US20100093757A1,CC(C)C(O)C(=O)O.Cc1ccc(N)nc1>>Cc1ccc(NC(=O)C(O)C(C)C)nc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110086889A1,CCOC(=O)CBr.Cc1cccc(-n2nnnc2S)c1C>>CCOC(=O)CSc1nnnn1-c1cccc(C)c1C,,CCOC(C)=O,CS(C)=O,c1ccncc1,,val
US05646173,C=CC(C)O.O=C1CCCc2cccc(Cl)c21>>CC=CCC1CCc2cccc(Cl)c2C1=O,,ClC(Cl)(Cl)Cl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US06329313B1,CCO[Si](CCl)(OCC)OCC.Oc1c(F)c(F)cc(F)c1F>>CCO[Si](COc1c(F)c(F)cc(F)c1F)(OCC)OCC,,Cc1ccccc1,,[Li]CCCC,,val
US06156700,Cn1c(C(F)(F)F)cc(=O)n(-c2ccc3snc(CS(C)=O)c3c2)c1=O.O=C(OO)c1cccc(Cl)c1>>Cn1c(C(F)(F)F)cc(=O)n(-c2ccc3snc(CS(C)(=O)=O)c3c2)c1=O,,ClCCl,,CCOCC,,val
US20060281789A1,CO.COC(OC)OC.O=Cc1ccc(OCCN2CCOCC2)c([N+](=O)[O-])c1>>COC(OC)c1ccc(OCCN2CCOCC2)c([N+](=O)[O-])c1,,ClCCl,,Cl,O=C([O-])[O-].[K+].[K+],val
US20080009541A1,COC(=O)[C@@H]1CCC(=O)N1C(C)C>>CC(C)N1C(=O)CC[C@H]1C(=O)O,,O,,CO,[Na+].[OH-],val
US20150336949A1,CC(C)(C)OC(=O)N1CCN(c2ccc(-c3cc4c(I)cn(C(=O)OC(C)(C)C)c4nc3C3CC3)cc2)CC1.Cc1nn(Cc2cc(F)cc(F)c2)c(C)c1B1OC(C)(C)C(C)(C)O1>>Cc1nn(Cc2cc(F)cc(F)c2)c(C)c1-c1cn(C(=O)OC(C)(C)C)c2nc(C3CC3)c(-c3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cc3)cc12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20120077811A1,C#Cc1cccc(N)c1.O=c1[nH]cnc2cnc(F)cc12>>C#Cc1cccc(Nc2ncnc3cnc(F)cc23)c1,CN(C)C=O,CC(=O)N(C)C,,O=S(Cl)Cl,O=C([O-])O.[Na+],val
US05312829,CCCC[C@@H](O)c1ccc(CC(C)C)cc1.CCOC(=O)CCCn1cc(C(=O)c2ccc(O)cc2)c2ccccc21>>CCCC[C@H](Oc1ccc(C(=O)c2cn(CCCC(=O)OCC)c3ccccc23)cc1)c1ccc(CC(C)C)cc1,,C1CCOC1,Cc1ccccc1,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04472407,Cc1ccc2c(Br)c(F)ccc2n1>>CC1CCc2c(ccc(F)c2Br)N1,[Pt],CC(=O)O,,[H][H],,val
US05162524,CC(OS(=O)(=O)C(F)(F)F)=C(C(=O)OC(c1ccccc1)c1ccccc1)N1C(=O)[C@@H](NC(=O)COc2ccccc2)[C@H]1SS(=O)(=O)c1ccc(C)cc1>>C=C=C(C(=O)OC(c1ccccc1)c1ccccc1)N1C(=O)[C@@H](NC(=O)COc2ccccc2)[C@H]1SS(=O)(=O)c1ccc(C)cc1,,C1CCOC1,,CCN(CC)CC,,val
US05356904,CCOC(=O)C1Cc2ccccc2N(C2CCN(C(=O)c3ccc(OCC)cc3OC)CC2)C1=O.NN>>CCOc1ccc(C(=O)N2CCC(N3C(=O)C(C(=O)NN)Cc4ccccc43)CC2)c(OC)c1,,CCO,,O,,val
US20080009486A1,CI.O=C1OC(O)c2cc(Cl)ccc21>>COC(=O)c1ccc(Cl)cc1C=O,,ClCCl,,,,val
US04017533,CC(=O)C#N.N#C/C(N)=C(/N)C#N>>CC(C#N)=N/C(C#N)=C(\N)C#N,,CC(C)=O,CCOCC,Cc1ccc(S(=O)(=O)O)cc1,,val
US05189054,CCOC(=O)c1[nH]c2cc(Cl)cc(Cl)c2c1N(CC(=O)c1ccccc1)Cc1ccccc1>>O=C(CN(Cc1ccccc1)c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)c1ccccc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20070196270A1,Nc1cc(Cl)ccc1/C=C/C(=O)O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(O)/C=C/c1ccc(Cl)cc1NC(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,Cl,val
US20100168418A1,CCOC(=O)C1(CCCn2c(=O)ccc3ccc(OC)cc32)CCN(CCSc2ccccc2)CC1>>COc1ccc2ccc(=O)n(CCCC3(C(=O)O)CCN(CCSc4ccccc4)CC3)c2c1,,CCO,,[Na+].[OH-],,val
US20040204408A1,CCN.COc1ccccc1N=C=O>>CCNC(=O)Nc1ccccc1O,,ClCCl,,BrB(Br)Br,,val
US20070185097A1,ClCCN1CCCC1.O=[N+]([O-])c1ccc(O)c(Cl)c1>>O=[N+]([O-])c1ccc(OCCN2CCCC2)c(Cl)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20150152047A1,CCSc1ccncc1CN.O=C(O)c1cc(Cl)cc(C(F)(F)F)c1>>CCSc1ccncc1CNC(=O)c1cc(Cl)cc(C(F)(F)F)c1,,ClCCl,,,,val
US20070270452A1,C=CCc1cc(C(=O)OC)ccc1O.CC(=O)OC(C)=O>>C=CCc1cc(C(=O)OC)ccc1OC(C)=O,,c1ccncc1,,,,val
US20030166639A1,Cc1cc(NC(=O)CC(=O)c2cccc(-c3cnccn3)c2)c(NC(=O)OC(C)(C)C)cc1C(F)(F)F>>Cc1cc2c(cc1C(F)(F)F)N=C(c1cccc(-c3cnccn3)c1)CC(=O)N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060030613A1,CC(C)(C)c1ccc(CN(CCc2ccccc2)C(=O)c2cccc3cc[nH]c23)cc1>>CC(C)(C)c1ccc(CN(CCc2ccccc2)C(=O)c2cccc3c2NCC3)cc1,,CC(=O)O,,[Na+].[OH-],,val
US20040152697A1,C[C@@H](C(=O)N1CCC[C@@H](NC(=O)OCc2ccccc2)C1)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O>>C[C@@H](C(=O)N1CCC[C@@H](NC(=O)OCc2ccccc2)C1)N1CC[C@H](NS(=O)(=O)c2ccc3ccccc3c2)C1=O,[Pd],CCO,,,,val
US20130274260A1,O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(CCl)cc1.OB(O)c1ccc(C(F)(F)F)cc1>>O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(Cc2ccc(C(F)(F)F)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,[I-].[Na+],,val
US05030646,CCOC(=O)CCCSc1cc2ccccc2n1C>>Cn1c(SCCCC(=O)O)cc2ccccc21,,CCO,,[Na+].[OH-],,val
US20120258952A1,CCc1nn(Cc2cccc(OC)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12>>CCc1nn(Cc2cccc(O)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20030153568A1,CCNC(=O)Nc1nc2c(s1)C(=O)C(Br)(Br)CC2>>CCNC(=O)Nc1nc2ccc(Br)c(O)c2s1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US05846990,CNCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C.O=C(O)c1ccc(F)c(F)c1>>Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)c2ccc(F)c(F)c2)c1C,,CN(C)C=O,ClCCl,CC(C)N=C=NC(C)C,,val
US20100105736A1,CCCN1CCC(O)(c2cccc(SC)c2)CC1>>CCCN1CC=C(c2cccc(SC)c2)CC1,,O=C(O)C(F)(F)F,,,,val
US06017926,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1cccc(F)c1>>CCOC(=O)C=Cc1cccc(F)c1,,ClCCl,,,,val
US20070213371A1,COC1(c2ccc(C(F)(F)F)cc2CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCO[Si](C)(C)C(C)(C)C)n2)CCCCCC1>>COC1(c2ccc(C(F)(F)F)cc2CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCO)n2)CCCCCC1,,CC1CCCO1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140213581A1,COC(=O)C(=O)C(C)Br.Nc1ccc(Cl)cn1>>Br.COC(=O)C(=O)C(C)n1cc(Cl)ccc1=N,,COCCOC,,,,val
US20020090661A1,CC(N)CCc1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CC(N)CCc1ccccc1.NC(=O)C(F)(F)F,,c1ccncc1,,,,val
US20090318436A1,COC(=O)[C@@H](C)n1ccc2ncccc2c1=O.Cl>>C[C@H](C(=O)O)n1ccc2ncccc2c1=O.Cl,,C1CCOC1,,,,val
US20140179667A1,Cc1cc(C)c(CN2CCOc3cnc(OC(C)C)c(C)c3C2=O)c(OCc2ccccc2)n1>>Cc1cc(C)c(CN2CCOc3cnc(OC(C)C)c(C)c3C2=O)c(=O)[nH]1,[Pd],CO,,,,val
US20130029971A1,CC(C)(C)N.CS(=O)(=O)c1ccc(NC(=O)c2cccc(Cl)c2)c(N2CCC(CC(=O)O)CC2)n1>>CC(C)(C)NC(=O)CC1CCN(c2nc(S(C)(=O)=O)ccc2NC(=O)c2cccc(Cl)c2)CC1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20160218293A1,CC1(C)C=CC=C2C=c3cc4c5ccccc5c5cc(Br)ccc5c4cc3=C21.CC1(C)OB(c2ccc(-c3ccc4ccc5c(-c6ccccc6)ccc6ccc3c4c65)cc2)OC1(C)C>>CC1(C)C=CC=C2C=c3cc4c5ccccc5c5cc(-c6ccc(-c7ccc8ccc9c(-c%10ccccc%10)ccc%10ccc7c8c%109)cc6)ccc5c4cc3=C21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20080255124A1,N#Cc1ccc(N(CCO)CC(F)(F)F)cc1C(F)(F)F.O=c1cccc[nH]1>>N#Cc1ccc(N(CCOc2ccccn2)CC(F)(F)F)cc1C(F)(F)F,,COCCOC,,,,val
US05707987,CC(C)(C)OC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]1C=O.OCc1ccc(Br)c2ccccc12>>CC(C)(C)OC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]1C(O)c1ccc(CO)c2ccccc12,,C1CCOC1,,[Cl-].[NH4+],,val
US20110183985A1,CON(C)C(=O)c1ccc2cccnc2c1-c1cc(F)cc(F)c1.C[Mg]Br>>CC(=O)c1ccc2cccnc2c1-c1cc(F)cc(F)c1,,C1CCOC1,,,,val
US20110118236A1,NC(=O)c1nn2c(c1[N+](=O)[O-])C(=O)NCC2>>NC(=O)c1nn2c(c1N)C(=O)NCC2,[Pd],CC(=O)O,,,,val
US20070185143A1,NC(=O)c1nn(C2CCN(Cc3ccccc3)CC2)c2c1CCc1cnc(NC3CCCC3)nc1-2>>NC(=O)c1nn(C2CCNCC2)c2c1CCc1cnc(NC3CCCC3)nc1-2,O=[Pt]=O,CC(=O)O,,CCOCC,,val
US20070208054A1,CCS(=O)(=O)c1ccc(N)cc1C#N.O=C(Cl)Oc1ccccc1>>CCS(=O)(=O)c1ccc(NC(=O)Oc2ccccc2)cc1C#N,,ClCCl,,c1ccncc1,,val
US20150291558A1,C[C@@H]1CC[C@@H](O)CN1C(=O)c1ccccc1-n1nccn1.N#Cc1ccnc(F)c1Cl>>C[C@@H]1CC[C@@H](Oc2nccc(C#N)c2Cl)CN1C(=O)c1ccccc1-n1nccn1,,CS(C)=O,,[H-].[Na+],,val
US20080114007A1,CS(=O)(=O)Cl.O=[N+]([O-])c1cccc(N2CCNCC2)c1>>CS(=O)(=O)N1CCN(c2cccc(N)c2)CC1,,ClCCl,,CCN(CC)CC,,val
US20150183759A1,C=C[Mg]Br.COc1ccc(CO[C@@H](C)[C@@H](C=O)Cc2ccccc2)cc1>>C=C[C@H](O)[C@@H](Cc1ccccc1)[C@H](C)OCc1ccc(OC)cc1,,C1CCOC1,,,,val
US20050267105A1,COc1cc(F)ccc1Br.N#C[Cu]>>COc1cc(F)ccc1C#N,,CN1CCCC1=O,,[NH4+].[OH-],,val
US04634689,CC(C)(C)O.N#Cc1ccc(C(=O)O)cc1>>CC(C)(C)OC(=O)c1ccc(C#N)cc1,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20160145214A1,c1c[nH]cn1.c1ccc2c(c1)Cc1ccccc1-2>>C1=CN(c2ccc3c(c2)Cc2ccccc2-3)CN1,,ClCCl,,,,val
US05137886,C1COCCN1.O=S(=O)(Cl)c1cccc(F)n1>>O=S(=O)(c1cccc(F)n1)N1CCOCC1,,ClC(Cl)Cl,,,,val
US20050096327A1,Fc1cccc(F)c1-c1nc(Cl)nc2ccccc12.N[C@H]1CCN(C(=O)OCc2ccccc2)C1>>O=C(OCc1ccccc1)N1CCC(Nc2nc(-c3c(F)cccc3F)c3ccccc3n2)C1,,Cc1ccccc1,,CCOC(C)=O,,val
US20150175602A1,CO[C@H](C)C(=O)O.Fc1ccc(OC2CCN(c3nc4c(nc3NCC(F)F)CCNC4)CC2)c(F)c1.O=C(O)C(F)(F)F>>CO[C@H](C)C(=O)N1CCc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1.O=C(O)C(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110319385A1,C1CCOC1.COC(=O)c1cc2nc(Cl)c(NNc3ccccc3)nc2cc1C>>COC(=O)c1cc2nc(Cl)c3nnc(-c4ccccc4)n3c2cc1C,,C1CCOC1,,O=S(Cl)Cl,,val
US20050222424A1,CCOC(=O)C(C)(C)Oc1ccc(CN(Cc2cccc(OC)c2)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C>>COc1cccc(CN(Cc2ccc(OC(C)(C)C(=O)O)c(C)c2)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)c1,,CCO,,[Na+].[OH-],,val
US20140371068A1,COC(=O)Cl.Cn1nnnc1NC(=O)c1ccc(C(F)(F)F)cc1S(C)(=O)=O>>COC(=O)N(C(=O)c1ccc(C(F)(F)F)cc1S(C)(=O)=O)c1nnnn1C,,C1CCOC1,O,[H-].[Na+],,val
US20030162795A1,Clc1cncc2sccc12.II>>ClC1=CN(I)C=C2SCC=C12,,C1CCOC1,C1CCOC1,[Li]CCCC,,val
US20040029901A1,CCN(CC)CC.CO.Nc1cc(OCc2ccccc2)ccc1C(=O)O>>Cc1nc(=O)c2ccc(OCc3ccccc3)cc2[nH]1,,CO,,,,val
US20040122028A1,COC(=O)C=Cc1c(Cc2ccccc2C(F)(F)F)sc2c1c(=O)n(C)c(=O)n2CC(C)C>>COC(=O)CCc1c(Cc2ccccc2C(F)(F)F)sc2c1c(=O)n(C)c(=O)n2CC(C)C,[Pd],CCO,,,,val
US20150210682A1,CCOC=C(C(C)=O)C(=O)OCC.COCCOc1cc2c(cc1Cl)C=NC(CC(C)C)C2>>CCOC(=O)C1=CN2C(CC(C)C)Cc3cc(OCCOC)c(Cl)cc3C2CC1=O,,CCO,,,,val
US04985432,O=[N+]([O-])O.O=c1cc(O)nc2sc(SCc3ccccc3)nn12>>O=c1c([N+](=O)[O-])c(O)nc2sc(SCc3ccccc3)nn12,,CC(=O)O,,O,,val
US05932599,CC(C)c1nc(Cl)c(N)c(NS(=O)(=O)c2ccc(N)cc2)n1.CCN>>CCNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NC(C)C)n1,,CCO,,,,val
US20140275083A1,COC(=O)c1cc(Cl)nc(Cl)n1.C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1>>COC(=O)c1cc(N2C(=O)OC[C@@H]2[C@@H](C)OC(C)(C)C)nc(Cl)n1,,CN(C)C=O,,[H-].[Na+],,val
US20120094982A1,CC(C)(C)OC(=O)n1c(=O)n(C(=O)OC(C)(C)C)c2ncc(Br)cc21.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(C)(C)OC(=O)n1c(=O)n(C(=O)OC(C)(C)C)c2ncc(B3OC(C)(C)C(C)(C)O3)cc21,,C1COCCO1,CCOC(C)=O,CC(=O)[O-].[K+],,val
US20110092485A1,CC#N.CCCN(CCC)C(=O)C1=Cc2ccc(Br)cc2N=C(N)C1.CCOC(C)=O.COC(=O)c1ccc(B(O)O)cc1>>CCCN(CCC)C(=O)C1=Cc2ccc(-c3ccc(C4CCOC4=O)cc3)cc2N=C(N)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120077796A1,COc1ccc(F)c(CC#N)c1.O=Cc1ccccc1>>COc1ccc(F)c(C(C#N)=Cc2ccccc2)c1,,CCO,,C,C[O-].[Na+],val
US20040191792A1,COc1ccc(Nc2ccccc2C(=O)O)cc1>>COc1ccc2[nH]c3ccccc3c(=O)c2c1,,O,,,,val
US05298652,CCCCCCCCCCCCCCOc1ccc(C(=O)OC)cc1OCCCCCCCCCCCCCC>>CCCCCCCCCCCCCCOc1ccc(C(=O)O)cc1OCCCCCCCCCCCCCC,,C1COCCO1,CO,[Na+].[OH-],,val
US20040132727A1,N#C[S-].O=C(Cl)Cc1ccccc1>>O=C(Cc1ccccc1)N=C=S,,CC#N,,O,,val
US20070249642A1,O=C(c1ccccc1)n1c(=O)c(I)cn(CCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)c1=O>>O=c1[nH]c(=O)n(CCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)cc1I,,CO,N,,,val
US20040138251A1,CCCC[Sn](CCCC)(CCCC)c1cnc(C=O)n1C.COc1cc(Nc2c(C#N)cnc3cc(I)sc23)c(Cl)cc1Cl>>COc1cc(Nc2c(C#N)cnc3cc(-c4cnc(C=O)n4C)sc23)c(Cl)cc1Cl,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20020169175A1,CC(C)(C)N.CCOC(Cc1ccc(OCCn2c(CC)nc(-c3ccccc3)cc2=O)cc1)C(=O)O>>CC(C)(C)N.CCOC(Cc1ccc(OCCn2c(CC)nc(-c3ccccc3)cc2=O)cc1)C(=O)O,,CC(C)O,,,,val
US20110172237A1,Cc1cc(NC(=O)CCl)ncn1.O=C(O[C@H]1CN2CCC1CC2)C1(c2ccccc2)CCCCCC1>>Cc1cc(NC(=O)C[N+]23CCC(CC2)[C@@H](OC(=O)C2(c4ccccc4)CCCCCC2)C3)ncn1.[Cl-],,CC#N,,,,val
US20010021718A1,CC(C)(C)OC(=O)C[C@@H](CCCC1CCCCC1)C(=O)O.COCCC(N)=NO>>COCCc1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20060111375A1,CCOC(=O)c1cc(C(C)=O)ccc1O.COc1cc2nccc(Cl)c2cc1OC>>CCOC(=O)c1cc(C(C)=O)ccc1Oc1ccnc2cc(OC)c(OC)cc12,CN(C)c1ccncc1,Clc1ccccc1Cl,,,,val
US20060052377A1,BrC(Br)(Br)Br.O[C@@H](c1cccc(F)c1)[C@@H]1CN(Cc2ccccc2)CCO1.O[C@H](c1cccc(F)c1)[C@H]1CN(Cc2ccccc2)CCO1>>Fc1cccc([C@@H](Br)[C@@H]2CN(Cc3ccccc3)CCO2)c1.Fc1cccc([C@H](Br)[C@H]2CN(Cc3ccccc3)CCO2)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05409943,Nc1ncccc1OCc1c(Cl)cccc1Cl.S=C=Nc1ccccc1>>S=C(Nc1ccccc1)Nc1ncccc1OCc1c(Cl)cccc1Cl,,CCOCC,,Cc1ccccc1,,val
US20050137241A1,CCCC1CC(=O)N(CNc2ccccc2[N+](=O)[O-])C1>>CCCC1CC(=O)N(CNc2ccccc2N)C1,[Pd],CO,O,,,val
US20100075953A1,CC(C)(C)OC(=O)N1CCN(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)CC2)CC1>>O=C(N1CCNCC1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)CC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20050182059A1,CCCO.Cc1cc(N)nnc1Cl>>CCCOc1nnc(N)cc1C,,O,,[Na],,val
US20090131461A1,COc1cc2c(Nc3cnc(NC(=O)c4ccccc4)nc3)ncnc2cc1OCc1ccccc1.Cl.Cl>>COc1cc2c(Nc3cnc(NC(=O)c4ccccc4)nc3)ncnc2cc1O.Cl.Cl,,O=C(O)C(F)(F)F,,,,val
US20130338152A1,Nc1ncnc2c1c(I)cn2[C@H]1C[C@@H](CN2C[C@@H]3C[C@H]2CS3)C1.O=S1(=O)CC2CC1CN2>>Nc1ncnc2c1c(I)cn2[C@@H]1C[C@H](CN2C[C@@H]3C[C@H]2CS3(=O)=O)C1,,CO,,,,val
US20100305096A1,CC(C)(C)OC(=O)N1CC(N2CC(F)C2)C1>>FC1CN(C2CNC2)C1,,ClCCl,O=C(O)C(F)(F)F,,,val
US05223536,N#CCc1cccc(Oc2ccccc2)c1.O=CCC(c1ccc(Cl)cc1)C1CC1>>N#CC(=CCC(c1ccc(Cl)cc1)C1CC1)c1cccc(Oc2ccccc2)c1,,CO,,C[O-].[Na+],,val
US20150045324A1,C=CC(=O)Cl.CN1CCN(c2ccc(Nc3nc(Oc4cccc(N)c4)c4sccc4n3)cc2)CC1>>C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1,,O,,C1CCOC1,O=C([O-])O.[Na+],val
US06262074B1,N#C[Cu].O=[N+]([O-])c1ccc(Br)c2ncccc12>>N#Cc1ccc([N+](=O)[O-])c2cccnc12,,CN(C)C=O,,ClCCl,,val
US20120142689A1,CC(C)(C)OC(=O)N1CC[C@H]([C@H](O)COCc2ccccc2)C1.Fc1ccc(C(F)(F)F)cc1>>CC(C)(C)OC(=O)N1CC[C@H]([C@@H](CO)Oc2ccc(C(F)(F)F)cc2)C1,[Pd],,,CN(C)C=O,[H-].[Na+],val
US20050107364A1,CC(C)(C)CC[C@@](C)(C(=O)N[C@H](CO)c1ccccc1)c1ccccc1.O=S(=O)(O)O>>CC(C)(C)CC[C@@](C)(C(=O)O)c1ccccc1,,C1COCCO1,,,,val
US20090270359A1,Cc1nn(Cc2ccc(C(=O)O)cc2)c(C)c1-c1ccc(C#N)c(Cl)c1.O=S(Cl)Cl>>Cc1nn(Cc2ccc(C(=O)Cl)cc2)c(C)c1-c1ccc(C#N)c(Cl)c1,,C1CCOC1,,CN(C)C=O,,val
US20060173018A1,Cc1ccc2c(N3CCN(C(=O)[C@H](O)CC(C)(C)C)CC3)nc(-c3c(O)cccc3F)nc2c1.Cl>>Cc1ccc2c(N3CCN(C(=O)[C@H](O)CC(C)(C)C)CC3)nc(-c3c(O)cccc3F)nc2c1.Cl,,ClCCl,,CCOCC,,val
US20080058320A1,COCCCc1cn(C)c2ccc(CC(CC(NC(=O)OC(C)(C)C)C3CO3)C(C)C)cc12.O=C1CCCCN1>>COCCCc1cn(C)c2ccc(CC(CC3NC(=O)OC3CN3CCCCC3=O)C(C)C)cc12,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20140080822A1,COC(=O)c1c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)ccc2c1ccn1nccc21>>COC(=O)c1c(N)ccc2c1ccn1nccc21,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20120053191A1,Cn1cnc2c(Cl)nc(C#CCCO)nc21.N>>Cn1cnc2c(N)nc(C#CCCO)nc21,,C1COCCO1,,O,,val
US20130225673A1,CCc1oc2ccccc2c1C(=O)c1ccc(OC)cc1>>CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1,,CN(C)C=O,,,,val
US20100144772A1,CCOC(=O)Cc1csc(NC(=O)OC(C)(C)C)n1>>CC(C)(C)OC(=O)Nc1nc(CCO)cs1,,CCO,,[BH4-].[Na+],,val
US20120059014A1,Cl.O=C1C[C@@H](c2cc(F)ccc2F)[C@H]([N+](=O)[O-])CN1Cc1ccccc1>>Cl.O=[N+]([O-])[C@@H]1CN(Cc2ccccc2)CC[C@H]1c1cc(F)ccc1F,,C1CCOC1,CO,B,CSC,val
US20110053916A1,C=CC(O)c1ccccc1-c1ncc(Cl)c(Nc2n[nH]c(C3CC3)c2Br)n1.CC(=O)Cl>>C=CC(O)c1ccccc1-c1ncc(Cl)c(Nc2nn(C(C)=O)c(C3CC3)c2Br)n1,,C1CCOC1,,,,val
US20030144263A1,NO.O=C1CCN(c2ccc(N3C[C@H](COc4ccon4)OC3=O)cc2F)CC1>>O=C1O[C@@H](COc2ccon2)CN1c1ccc(N2CCC(=NO)CC2)c(F)c1,,CO,ClCCl,Cl,CC(=O)[O-].[Na+],val
US20020147334A1,CCOC(=O)C[C@H](Cc1ccc(OCCc2ccc3c(n2)NCCC3)cc1)c1nccs1>>O=C(O)C[C@H](Cc1ccc(OCCc2ccc3c(n2)NCCC3)cc1)c1nccs1,,C1CCOC1,O,[Li+].[OH-],,val
US20130245006A1,CCCCC(=O)CBr.Cc1cc(C(=O)OC(C)C)ccn1>>CCCCC(=O)C[n+]1ccc(C(=O)OC(C)C)cc1C.[Br-],,CCC(C)=O,,,,val
US20130167431A1,C1CCOC1.CCCCCCCC/C=C\CCCCCCCC(=O)Cl.CCOC(=O)CC(O)(CC(=O)OCC)C(=O)OCC>>CCCCCCCC/C=C\CCCCCCCC(=O)O.CCOC(=O)CC(O)(CC(=O)OCC)C(=O)OCC,,C1CCOC1,,[H-].[Na+],,val
US20080280906A1,O=C(Cl)c1ccc(I)cc1.O[C@@H]1CCNC1>>O=C(c1ccc(I)cc1)N1CC[C@@H](O)C1,,CC#N,ClCCl,[Cl-].[NH4+],,val
US20080234237A1,CC(=O)CCl.O=C1CCc2cc([N+](=O)[O-])ccc2N1>>CC(=O)CN1C(=O)CCc2cc([N+](=O)[O-])ccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04256897,CCSC(=S)OC.N[C@@H](CC(=O)O)C(=O)O>>CCOC(=S)N[C@@H](CC(=O)O)C(=O)O,,O,,CO,[Na+].[OH-],val
US20060063762A1,CCOC(=O)c1cccc2c(CCN[C@@H](C)[C@H](O)c3ccc(O)cc3)c[nH]c12>>C[C@H](NCCc1c[nH]c2c(C(=O)O)cccc12)[C@H](O)c1ccc(O)cc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20040235841A1,CON(C)C(=O)c1ccnc(Cl)c1.C[Mg]Br>>CC(=O)c1ccnc(Cl)c1,,C1CCOC1,,,,val
US06214873B1,BrCCc1ccccc1.COC(Cl)Cl.O>>O=Cc1ccc(CCBr)cc1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20110172245A1,CN1CCNCC1.Cc1ccc(Oc2ccc3nc(NC(=O)CCl)sc3c2)cc1NC(=O)c1cccc(C(C)(C)C#N)c1>>Cc1ccc(Oc2ccc3nc(NC(=O)CN4CCN(C)CC4)sc3c2)cc1NC(=O)c1cccc(C(C)(C)C#N)c1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20060025433A1,BrCCCCBr.NC1CCC(CNC(=O)OCc2ccccc2)CC1>>O=C(NCC1CCC(N2CCCC2)CC1)OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20070270399A1,CC(C)(C)OC(=O)CC(C#N)c1ccc(F)cc1>>NCC(CCO)c1ccc(F)cc1,,O,,C1CCOC1,Cl,val
US20130336918A1,CC(C)(C)OC(=O)CCSCc1cccc(C(=O)O)c1.Cc1ccc(-c2cnc(NC(=O)c3cc(N4CCCCC4)ccc3N)nc2)cc1C>>Cc1ccc(-c2cnc(NC(=O)c3cc(N4CCCCC4)ccc3NC(=O)c3cccc(CSCCC(=O)OC(C)(C)C)c3)nc2)cc1C,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20040110802A1,CCOC(=O)C(=O)c1cc(Br)ccc1F.NO>>CCOC(=O)C(=NO)c1cc(Br)ccc1F,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20100099680A1,CS(=O)(=O)c1cccc(C(F)(F)F)c1.O=[N+]([O-])O>>CS(=O)(=O)c1cc([N+](=O)[O-])cc(C(F)(F)F)c1,,O=S(=O)(O)O,,,,val
US20130109662A1,C=C1CC(=O)O1.CCCNCCC>>CCCN(CCC)C(=O)CC(C)=O,,CO,,,,val
US20060148858A1,CCOC(=O)C(C)(C)Oc1ccc(CC)c(OCOC)c1>>CCOC(=O)C(C)(C)Oc1ccc(CC)c(O)c1,Cl,CCO,,,,val
US20080153836A1,COC(=O)c1cc(-c2ccnn2C)c(C(C)C)cc1NC(=O)Oc1ccc(Cl)cc1.CS(=O)(=O)NN>>CC(C)c1cc2[nH]c(=O)n(NS(C)(=O)=O)c(=O)c2cc1-c1ccnn1C,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US06420375B1,Brc1ccc2ccccc2c1.O=C1CCCO1>>O=C(CCCO)c1ccc2ccccc2c1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US20100311793A1,CC(=O)Oc1ccccc1C(=O)O.COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2>>CC(=O)Oc1ccccc1C(=O)[O-].COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2,,CC(C)=O,CCOC(C)=O,,,val
US05665718,NC(=O)c1ncn2c1[C@@H]1CCN1C(=O)c1ccccc1-2>>N#Cc1ncn2c1[C@@H]1CCN1C(=O)c1ccccc1-2,,C1COCCO1,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US05202344,CCOC(=O)C[C@@H]1CN(c2ccccc2)C(=O)[C@@H]1N.O=C(O)c1cc2ccccc2[nH]1>>O=C(O)C[C@@H]1CN(c2ccccc2)C(=O)[C@@H]1NC(=O)c1cc2ccccc2[nH]1,,CN(C)C=O,,,,val
US20030216460A1,COC(=O)c1cc2[nH]cnc2c(F)c1Nc1ccccc1.O=C1CCC(=O)N1I>>COC(=O)c1cc2[nH]cnc2c(F)c1Nc1ccc(I)cc1,,CO,,C1CCOC1,,val
US20060106089A1,Nc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1.O=S(=O)(Cl)c1cc(C(F)(F)F)ccc1Cl>>O=S(=O)(Nc1ccccc1NS(=O)(=O)c1cc(C(F)(F)F)ccc1Cl)c1ccc(Cl)cc1,,ClCCl,c1ccncc1,,,val
US20150175604A1,CN(C)S(=O)(=O)Cl.Cc1nnc2ccc3c(cc(-c4ccn(C5CNC5)n4)n3Cc3cccc(Cl)c3)n12.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F>>Cc1nnc2ccc3c(cc(-c4ccn(C5CN(S(=O)(=O)N(C)C)C5)n4)n3Cc3cccc(Cl)c3)n12.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20090209532A1,COc1cc(C=O)ccc1OCc1ccccc1.O=C1CSC(=S)N1>>COc1cc(/C=C2\SC(=S)NC2=O)ccc1OCc1ccccc1,,CC(=O)O,,O,CC(=O)[O-].[Na+],val
US20100173999A1,CCC/C=C\CC(C)CC(O)C#CC(C)O>>CCC/C=C\CC(C)CC(O)CCC(C)O,[Pd],CCO,,c1ccc2ncccc2c1,,val
US06376701B1,COC(=O)CC(C)=O.OC1CCCCC1>>CC(=O)CC(=O)OC1CCCCC1,,Cc1ccccc1,,,,val
US20100292255A1,CC(C)(C)OC(=O)N1CCC(O)CC1.Nc1ncnc2nc[nH]c12>>CC(C)(C)OC(=O)N1CCC(n2cnc3c(N)ncnc32)CC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160096834A1,CC(C)(C)OC(=O)NCCOc1cc(Cl)cc(F)c1C(=O)O>>NCCOc1cc(Cl)cc(F)c1C(=O)O,,CO,Cl,,,val
US05654297,Cc1ccccc1N=C=O.Nc1ccc(C(=O)N2CCCCc3sccc32)cc1>>Cc1ccccc1NC(=O)Nc1ccc(C(=O)N2CCCCc3sccc32)cc1,,C1CCOC1,,,,val
US20060094767A1,O=Cc1ccc(OC(F)(F)F)cc1.OC1CCNCC1>>OC1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1,,CC#N,,O=C([O-])O.[Na+],,val
US20160137643A1,CCOC(=O)c1cnc2cnccc2c1.O=C1CCC(=O)N1Br>>CCOC(=O)c1cnc2cncc(Br)c2c1,,CC(=O)O,,,,val
US20160214956A1,BrCCCOC1CCCCO1.CCOC(=O)c1cnn(-c2cccc(-c3ccccc3CCc3ccc(O)cc3)n2)c1C(F)(F)F>>CCOC(=O)c1cnn(-c2cccc(-c3ccccc3CCc3ccc(OCCCOC4CCCCO4)cc3)n2)c1C(F)(F)F,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080004442A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)c1cc(I)cc([N+](=O)[O-])c1>>COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)cc([N+](=O)[O-])c1,,CS(C)=O,,CC(=O)[O-].[K+],,val
US20160060257A1,COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC(=O)O)CC3)cc12.CS(N)(=O)=O>>COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC(=O)NS(C)(=O)=O)CC3)cc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US06548494B1,CC#N.COC(=O)CCCC#Cc1cccc2c1NCCNC2=O>>COC(=O)CCC/C(C)=C/c1cccc2c1NCCNC2=O,Cl[Pd]Cl,,,,,val
US20160068559A1,CNC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C2OC(C)(C)O[C@@H]21.C[C@@H](CC=O)NC(=O)Nc1ccc(C(C)(C)C)cc1>>C[C@@H](CCN(C)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21)NC(=O)Nc1ccc(C(C)(C)C)cc1,,ClCCCl,,O=C([O-])O.[Na+],,val
US20140128374A1,C1=COCCC1.Clc1nccc2[nH]ncc12>>Clc1nccc2c1cnn2C1CCCCO1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20010012901A1,C1CCC(NC2CCCCC2)CC1.Cc1c2c(c3c(c1S(=O)(=O)NC(=N)c1ccccc1)CCCC3)OC(C)(CC(=O)O)CC2>>C1CCC(NC2CCCCC2)CC1.Cc1c2c(c3c(c1S(=O)(=O)NC(=N)c1ccccc1)CCCC3)OC(C)(CC(=O)O)CC2,,CCOC(C)=O,,,,val
US20070208024A1,CS(=O)(=O)Cl.Nc1ccc(Br)cc1F>>CS(=O)(=O)Nc1ccc(Br)cc1F,,ClCCl,c1ccncc1,,,val
US20090105242A1,O=[N+]([O-])c1ccc(N2CCN(C3CCC3)CC2)cc1>>Nc1ccc(N2CCN(C3CCC3)CC2)cc1,[Pd],CCO,,,,val
US20150246892A1,CC(C)(C)OC(=O)[C@@H](CCCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(c2ccccn2)C1=O>>O=C(O)[C@@H](CCCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(c2ccccn2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US08445538B2,CCC[C@H](c1ccc(C(=O)NCCC(=O)OCC)cc1)[C@@H](O)c1ccc(Cl)cc1.Cc1cc(Br)c2ccccc2c1>>CCC[C@H](c1ccc(C(=O)NCCC(=O)OCC)cc1)C(c1ccc(Cl)cc1)c1cccc2c(Br)cc(C)cc12,,O=C(O)C(F)(F)F,,,,val
US05273999,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=c1ccc2c(O)cccc2o1>>O=c1ccc2c(OS(=O)(=O)C(F)(F)F)cccc2o1,,CCOCC,ClCCl,Cl,c1ccncc1,val
US20060100201A1,CC(=O)CCC(C)=O.Nc1cc(Cl)ccc1[N+](=O)[O-]>>Cc1ccc(C)n1-c1cc(Cl)ccc1[N+](=O)[O-],O=S(=O)(O)O,C1CCOC1,ClCCl,Cc1ccccc1,,val
US20080070976A1,CC(=O)c1ccc(OCc2ccc(OC(F)(F)F)cc2)cc1.[NH4+]>>CC(N)c1ccc(OCc2ccc(OC(F)(F)F)cc2)cc1,,CO,,[BH3-]C#N.[Na+],,val
US20060116363A1,CCC(C)=O.Oc1ccc(Br)cc1.c1ccncc1>>Brc1ccc(OCc2cccnc2)cc1,,CCC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100249118A1,CC(C)(C)[Si](C)(C)Oc1ccc(F)cc1F.CN(C)C=O>>CC(C)(C)[Si](C)(C)Oc1ccc(F)c(C=O)c1F,,C1CCOC1,,O,[Li]CCCC,val
US20150210688A1,CCOC(=O)C(C)C=O.NNCc1ccccc1>>Cc1cnn(Cc2ccccc2)c1O,,CCO,,Cl,,val
US20110152260A1,CCOC(=O)c1ccc(F)c([N+](=O)[O-])c1.NC1CCCCC1>>CCOC(=O)c1ccc(NC2CCCCC2)c([N+](=O)[O-])c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20100041726A1,CCc1sc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)cc1-c1ccnn1C>>CCc1sc(C(=O)N[C@H](CN)Cc2ccccc2C(F)(F)F)cc1-c1ccnn1C,,C1CCOC1,CO,NN,,val
US20020019401A1,NC1CC2CC(=O)CC2C1.O=[N+]([O-])c1ccc(F)cc1F>>O=C1CC2CC(Nc3cc(F)ccc3[N+](=O)[O-])CC2C1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20050107371A1,CC(C)(C)OC(=O)C1COc2cc(O)ccc2C1.Cc1oc(-c2ccccc2)nc1CCCOS(C)(=O)=O>>Cc1oc(-c2ccccc2)nc1CCCOc1ccc2c(c1)OCC(C(=O)OC(C)(C)C)C2,,CC#N,CCOCC,O=C([O-])[O-].[K+].[K+],,val
US20050267096A1,Brc1cccc2[nH]ncc12.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>Brc1cccc2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cc12,,ClCCl,O,CCN(CC)CC,,val
US20040092537A1,CN(C)c1nc(-c2ccco2)c2ccn(COCC[Si](C)(C)C)c2n1>>CN(C)c1nc(-c2ccco2)c2ccnc-2[nH]1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US05395941,C1=COCCC1.CC(=O)NCCOC(=O)C1=C(C)NC(C)=C(C(=O)O)[C@@H]1c1cccc([N+](=O)[O-])c1>>CC(=O)NCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC2CCCCO2)[C@H]1c1cccc([N+](=O)[O-])c1,,C1CCOC1,CCOC(C)=O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140323463A1,CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1Cl.NCCCN>>CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1NCCCN,,CN1CCCC1=O,,,,val
US20150361060A1,CCOC(=O)C=NO.NCC(=O)N1CCCCCC1>>O=C(C=NO)NCC(=O)N1CCCCCC1,,CCO,,,,val
US20120220551A1,O=[N+]([O-])O.Oc1cncc(Br)c1>>O=[N+]([O-])c1ncc(Br)cc1O,,O=S(=O)(O)O,,,,val
US03931206,CCOC(=O)COc1cc(Cl)cnc1Cl>>CCOC(=O)COc1cncc(Cl)c1,,CC(=O)O,,,,val
US04346220,NNC(=S)NN.O=CC(=O)O>>Nn1c(=O)cn[nH]c1=S,,O,,,,val
US20150274673A1,C=CCBr.Cc1ccc(Cl)c(O)c1>>C=CCOc1cc(C)ccc1Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050026976A1,Cc1cccc(NC(=O)Nc2ccc(-c3cc(OCC(=O)OC(C)(C)C)cc4c3CNC4=O)cc2)c1>>Cc1cccc(NC(=O)Nc2ccc(-c3cc(OCC(=O)O)cc4c3CNC4=O)cc2)c1,,O=C(O)C(F)(F)F,,,,val
US04431653,Cc1nc(C)c(C)o1.NCCCC1CCN(C=O)CC1>>Cc1nc(C)n(CCCC2CCN(C=O)CC2)c1C,,CC(=O)O,,,,val
US20040087789A1,Clc1ccc(C#Cc2cncnc2Cl)cc1.Nc1ccc(O)cc1>>Cl.Oc1ccc(Nc2ncncc2C#Cc2ccc(Cl)cc2)cc1,,CCO,,,,val
US20140256756A1,CNC.O=S(=O)(Cl)c1ccc(F)c(F)c1>>CN(C)S(=O)(=O)c1ccc(F)c(F)c1,,CN(C)C=O,,CCOCC,,val
US04375536,C#C[Si](C)(C)C.O=C(C(=O)c1ccc(Oc2ccc(Br)cc2)cc1)c1ccccc1>>C[Si](C)(C)C#Cc1ccc(Oc2ccc(C(=O)C(=O)c3ccccc3)cc2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCN(CC)CC,,Cl,,val
US20040082781A1,CCc1nc2c(-c3ccc(C)cc3C)ccnn2c1C(=O)OC>>CCc1nc2c(-c3ccc(C)cc3C)ccnn2c1C(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20100317704A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.O=C1NC2(CCCC2)N=C1c1ccc(Br)cc1>>O=C1NC2(CCCC2)N=C1c1ccc(-c2ccccn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,Cc1ccccc1,,,val
US20110110889A1,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]ccc3c2)c1F.O=C1CCC(=O)N1Br>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cc(Br)c3c2)c1F,,ClC(Cl)Cl,,,,val
US20150266881A1,CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(F)c(C(=O)O)c1.Cc1nnc(N)s1>>Cc1nnc(NC(=O)c2cc([C@@H]3C[C@H]3NC(=O)OC(C)(C)C)ccc2F)s1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05654299,CN(CC(CCOC1CCCCO1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1>>CN(CC(CCO)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20090264445A1,COC(=O)[C@H](CC(C)C)N1CC(Oc2ccc(F)cc2F)=CC1=O>>CC(C)C[C@@H](C(=O)O)N1CC(Oc2ccc(F)cc2F)=CC1=O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US04745198,CCCCC=CC(=O)O>>CCCCCCC(=O)O,[Pd],CCO,,[H][H],,val
US20050032786A1,CC(C)(C)OC(=O)COc1ccc2sc(-c3ccccn3)nc(=O)c2c1>>O=C(O)COc1ccc2sc(-c3ccccn3)nc(=O)c2c1,,O=C(O)C(F)(F)F,,,,val
US20060189601A1,COc1ccc2nccc(OS(=O)(=O)C(F)(F)F)c2n1.OCCN1CCNCC1>>COc1ccc2nccc(N3CCN(CCO)CC3)c2n1,,CN(C)C=O,,,,val
US20040058965A1,Cc1nn(-c2ccccn2)cc1COc1ccc(CO)cc1.N#Cc1cccnc1Cl>>Cc1nn(-c2ccccn2)cc1COc1ccc(COc2ncccc2C#N)cc1,,O,,CN(C)C=O,[H-].[Na+],val
US20070149561A1,COc1ccc(Cn2cc(-c3ccnc4[nH]ccc34)c(-c3ccc([N+](=O)[O-])cc3)n2)cc1>>O=[N+]([O-])c1ccc(-c2n[nH]cc2-c2ccnc3[nH]ccc23)cc1,,O,O=C(O)C(F)(F)F,,,val
US03931277,CNS(=O)(=O)c1ccccc1.O=C=NS(=O)(=O)Cl>>CN(S(=O)(=O)N=C=O)S(=O)(=O)c1ccccc1,,Clc1ccccc1,,,,val
US20050148623A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N[C@H](C(=O)OCc1ccccc1)C(C)(C)CO>>CC(=O)OCC(C)(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O,CN(C)c1ccncc1,ClCCl,,,,val
US04386085,BrBr.CC(C)CCN(C)c1ccccc1>>CC(C)CCN(C)c1ccc(Br)cc1,,CC(=O)O,,O,,val
US06197729B1,COC(=O)C(F)(F)F.COc1ccc([Mg]Br)cc1>>COc1ccc(C(=O)C(F)(F)F)cc1,,C1CCOC1,CCOCC,Cl,,val
US06265588B1,C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)NCC(=O)O.Nc1ccc(N)cc1>>CC(C)(C)OC(=O)NCC(=O)NNc1ccc(N)cc1,,C1CCOC1,,,,val
US20060135578A1,COc1cc(COc2cc(CO)n(-c3ccccc3)n2)ccc1OCc1nc(-c2ccco2)oc1C.c1nc[nH]n1>>COc1cc(COc2cc(Cn3cncn3)n(-c3ccccc3)n2)ccc1OCc1nc(-c2ccco2)oc1C,,C1CCOC1,CCOC(C)=O,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20120142671A1,Cc1cc(Nc2cc(N[C@H](COCc3ccccc3)C(N)=O)ccc2C#N)sn1.OO>>Cc1cc(Nc2cc(N[C@H](COCc3ccccc3)C(N)=O)ccc2C(N)=O)sn1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150284370A1,NCCO.O=C(O)c1ccc(Br)cc1>>O=C(NCCO)c1ccccc1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040092546A1,C[C@H](N)c1ccccc1.O=C(Cl)c1ccc[nH]1>>C[C@H](NC(=O)c1ccc[nH]1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US05274125,CC(C)=CCC/C(C)=C/CO>>CC(C)=CCC[C@@H](C)CCO,,CO,,O=O,,val
US20140073622A1,CO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1N(Cc1ccccc1)C(=O)OCc1ccccc1>>CO[C@@H]1CNCC[C@@H]1N(Cc1ccccc1)C(=O)OCc1ccccc1,,CO,,CCOC(C)=O,Cl,val
US20140018361A1,COC(=O)CC(=O)OC.O=C1CCCC1Cl>>COC(=O)C(C(=O)OC)C1CCCC1=O,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US06787541B1,CCOC(=O)c1nc(C(=O)c2cccs2)c2sccc2n1>>O=C(O)c1nc(C(=O)c2cccs2)c2sccc2n1,,CO,O,Cl,[Na+].[OH-],val
US20100249123A1,N#CC1(c2cccc([N+](=O)[O-])c2)CC1>>N#CC1(c2cccc(N)c2)CC1,[Pd],CO,,,,val
US20160214956A1,CCOC(=O)c1cnn(-c2cccc(-c3cc(F)ccc3C=O)n2)c1C(F)(F)F.CCOP(=O)(Cc1ccc(OC)cc1C)OCC>>CCOC(=O)c1cnn(-c2cccc(-c3cc(F)ccc3/C=C/c3ccc(OC)cc3C)n2)c1C(F)(F)F,,C1CCOC1,O,[H-].[Na+],,val
US20060004017A1,CN1CCNCC1.COc1cc2c(Oc3ccc4[nH]c(C)cc4c3)ncnc2cc1OC[C@H]1CO1>>COc1cc2c(Oc3ccc4[nH]c(C)cc4c3)ncnc2cc1OC[C@H](O)CN1CCN(C)CC1,,CN(C)C=O,,,,val
US20080166359A1,NO.O=C1CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1>>O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(=NO)C1,,C1COCCO1,,,,val
US20020198195A1,COC(=O)c1ccc(F)c(O)c1.OCCc1ccc(Cl)cc1>>COC(=O)c1ccc(F)c(OCCc2ccc(Cl)cc2)c1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070093496A1,Cc1ccccc1S(=O)(=O)Oc1c2c(n3c1C(=O)N(Cc1ccc(F)cc1)CC3)CCN(Cc1ccncc1)C2=O>>O=C1c2c(O)c3n(c2CCN1Cc1ccncc1)CCN(Cc1ccc(F)cc1)C3=O,,CO,,C[O-].[Na+],,val
US04716169,CI.CS(=O)(=O)Nc1cc(O)ccc1-c1cn2ccccc2n1>>CN(c1cc(O)ccc1-c1cn2ccccc2n1)S(C)(=O)=O,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06054591,C=O.CC(C)c1nc(COC(N)=O)n(Cc2ccncc2)c1Sc1cc(Cl)cc(Cl)c1.c1ccc(CNCc2ccccc2)cc1>>CC(C)c1nc(COC(=O)NCN(Cc2ccccc2)Cc2ccccc2)n(Cc2ccncc2)c1Sc1cc(Cl)cc(Cl)c1,,CCOC(C)=O,,,,val
US20050043336A1,CC#N.ClCc1ccccn1.Fc1cccc(COc2ccc(Nc3ncnc4cccc(OC5CCOCC5)c34)cc2Cl)c1>>CN1CCC(Oc2cccc3ncnc(Nc4ccc(OCc5ccccn5)c(Cl)c4)c23)CC1,C1COCCOCCOCCOCCOCCO1,,,Cl,O=C([O-])[O-].[K+].[K+],val
US20110112103A1,CCOC(=O)C(C#N)C1(C)CCN(c2ccc(F)cc2)CC1>>CC1(CC#N)CCN(c2ccc(F)cc2)CC1,,CS(C)=O,O,[Cl-].[Li+],,val
US08476253B2,Cc1cc(NCCCCCC(=O)N(C)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)sc1C(=O)N(C)CCN(C)C(=O)OC(C)(C)C>>CNCCN(C)C(=O)c1sc(NCCCCCC(=O)N(C)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)cc1C,,Cc1ccccc1,,CO,Cl,val
US05719182,CCOC(=O)C1C(c2ccc3c(c2)OCO3)c2ccccc2C1c1ccc2c(c1)OCO2>>O=C(O)C1C(c2ccc3c(c2)OCO3)c2ccccc2C1c1ccc2c(c1)OCO2,,CCO,,[Na+].[OH-],,val
US20090054402A1,CCOC(=O)c1[nH]c2c(Br)cccc2c1CCCOc1cccc2ccccc12.COCCl>>CCOC(=O)c1c(CCCOc2cccc3ccccc23)c2cccc(Br)c2n1COC,,C1CCOC1,,[H-].[Na+],,val
US20090253758A1,Cc1c(N[C@@H](c2nnc(-c3ccc(NC(=O)c4ccccc4)cc3)o2)[C@@H](C)O[Si](C)(C)C(C)(C)C)ccc(C#N)c1Cl>>Cc1c(N[C@@H](c2nnc(-c3ccc(NC(=O)c4ccccc4)cc3)o2)[C@@H](C)O)ccc(C#N)c1Cl,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150031689A1,Clc1ccc(-n2c(-c3ccccc3Cl)nc3c(Cl)ncnc32)cc1.NCC1CCC(CN)CC1>>NCC1CCC(CNc2ncnc3c2nc(-c2ccccc2Cl)n3-c2ccc(Cl)cc2)CC1,,C1COCCO1,,,,val
US20160068559A1,CC(C)(C)c1ccc(N=C=O)cc1.CC[C@H](N)CC(=O)OC>>CC[C@@H](CC(=O)OC)NC(=O)Nc1ccc(C(C)(C)C)cc1,,ClCCl,,,,val
US05763437,CC(=O)c1cccnc1CO.O=S(Cl)Cl>>CC(=O)c1cccnc1CCl,,ClC(Cl)Cl,ClCCl,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US05145870,CCCCN.OC(CCI)c1ccccc1>>CCCCNCCC(O)c1ccccc1,,C1CCOC1,,,,val
US20160272592A1,C=O.Cc1c(OCC2CCNCC2)nn(-c2ccccc2)c1NC(=O)NCc1ccccc1OC(F)(F)F>>Cc1c(OCC2CCN(C)CC2)nn(-c2ccccc2)c1NC(=O)NCc1ccccc1OC(F)(F)F,,CO,,O=CO,,val
US20110166133A1,CC(=O)c1cccc(F)c1.NCCCCl>>CC(=NCCCCl)c1cccc(F)c1,,O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20050261294A1,CC(C)(C)OC(=O)CBr.COc1ccc(OC)c(S(=O)(=O)Nc2nc(-c3ccc(C(C)C)cc3)cs2)c1>>COc1ccc(OC)c(S(=O)(=O)N(CC(=O)OC(C)(C)C)c2nc(-c3ccc(C(C)C)cc3)cs2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100120785A1,Cc1nc(S(=O)(=O)Cl)cn1C.O=Cc1cn[nH]c1>>Cc1nc(S(=O)(=O)n2cc(C=O)cn2)cn1C,,ClCCl,,CCN(CC)CC,,val
US20160152605A1,CC(C)(C)[Si](O[C@H]1CCN(C(=O)OCc2ccccc2)[C@H](c2ccc(C#N)cc2)C1)(c1ccccc1)c1ccccc1>>N#Cc1ccc([C@@H]2C[C@@H](O)CCN2C(=O)OCc2ccccc2)cc1,,CCOCC,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20070105842A1,C#CCc1ccccc1.Clc1cccc(I)c1Cl>>Clc1cccc(C#CCc2ccccc2)c1Cl,[Cu]I,CCN(CC)CC,,,,val
US20050059687A1,CC(Br)c1nc2ccc(C#N)cc2c(=O)n1C.COc1ccc(S(=O)(=O)N2CCNCC2)cc1>>COc1ccc(S(=O)(=O)N2CCN(C(C)c3nc4ccc(C#N)cc4c(=O)n3C)CC2)cc1,,CC#N,,,,val
US20120094972A1,Cc1nc2ccc(Cl)cc2c(N2CC(C)(C)c3ccc(N4CCOCC4)cc32)c1C>>Cc1nc2ccccc2c(N2CC(C)(C)c3ccc(N4CCOCC4)cc32)c1C,[Pd],CO,,CCN(CC)CC,N#N,val
US20140094507A1,CC(C)(C)OC(=O)[C@H](N)Cc1ccccc1.O=C(Cl)c1sc2cc(C(F)(F)F)ccc2c1Cl>>O=C(N[C@H](Cc1ccccc1)C(=O)O)c1sc2cc(C(F)(F)F)ccc2c1Cl,,ClCCl,,CCN(CC)CC,,val
US05238954,CC(=O)O.N#CCc1cccc2c(=O)cc(-c3cccc(F)c3)oc12.O=S(=O)(O)O>>O=C(O)Cc1cccc2c(=O)cc(-c3cccc(F)c3)oc12,,O,,,,val
US06627651B1,CCCOCCOc1ccccc1CO.COC(=O)C1=Cc2cc(O)ccc2S(=O)(=O)CC1>>CCCOCCOc1ccccc1COc1ccc2c(c1)C=C(C(=O)OC)CCS2(=O)=O,,C1CCOC1,Cc1ccccc1,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080070919A1,Cc1cc2c(OCC(O)CN3CC4CC=CCC3CN4c3ccc4ccccc4c3)cccc2[nH]1>>Cc1cc2c(OCC(O)CN3CC4CCCCC3CN4C3CCc4ccccc4C3)cccc2[nH]1,[Pd],CO,,,,val
US20060148858A1,CCOC(=O)CCc1cc(O)nn1-c1ccccc1.OCCCc1cn(-c2ccc(C(F)(F)F)cn2)nc1OCc1ccccc1>>O=C(O)CCc1cc(OCCCc2cn(-c3ccc(C(F)(F)F)cn3)nc2OCc2ccccc2)nn1-c1ccccc1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20160145245A1,CN(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)[C@H](CN1CCCC1)c1cccc([N+](=O)[O-])c1>>CN(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)[C@H](CN1CCCC1)c1cccc(N)c1,[Pd],CCO,CCOC(C)=O,,,val
US20150353581A1,CC(N)(C#N)COc1cc2c(cc1C(F)(F)F)COB2O.O=C(O)c1ccc(OC(F)(F)F)cc1>>CC(C#N)(COc1cc2c(cc1C(F)(F)F)COB2O)NC(=O)c1ccc(OC(F)(F)F)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160194332A1,CC1C[C@H](NC(=O)OC(C)(C)C)Cn2c1c(-c1cnc3ccccc3c1)c1c(N)ncnc12>>CC1C[C@H](N)Cn2c1c(-c1cnc3ccccc3c1)c1c(N)ncnc12,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20060111375A1,CC(C)COC(=O)c1ccccc1O.COc1cc2nccc(Cl)c2cc1OC>>COc1cc2nccc(Oc3ccccc3C(=O)OCC(C)C)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,,,val
US20090306041A1,Brc1cccc(Br)c1.CN(C)c1ccc2c(c1)CCNC2=O>>CN(C)c1ccc2c(c1)CCN(c1cccc(Br)c1)C2=O,,ClCCl,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20040029886A1,O=C(Oc1cc(Cl)c(O)c(I)c1)c1ccccc1.OCCCOc1ccc(C(F)(F)F)cn1>>O=C(Oc1cc(Cl)c(OCCCOc2ccc(C(F)(F)F)cn2)c(I)c1)c1ccccc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070105943A1,CCOC(=O)c1cc2c(nc1N)CCC2>>Nc1nc2c(cc1C(=O)O)CCC2,,CCO,,Cl,[Na+].[OH-],val
US20040023974A1,COC(=O)c1cccc(N2CC(=O)NS2(=O)=O)c1>>O=C1CN(c2cccc(C(=O)O)c2)S(=O)(=O)N1,,CO,O,[Na+].[OH-],,val
US20110028715A1,COCCOc1nc(N)c2nc(OC)[nH]c2n1.CS(=O)(=O)OCc1ccc(Br)nc1>>COCCOc1nc(N)c2nc(OC)n(Cc3ccc(Br)nc3)c2n1,,CN(C)C=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20120142665A1,CCOC(=O)c1c(C(=O)N2CCC2)cnn1C.Nc1ccn2nc(N3CCOCC3)nc2c1>>Cn1ncc(C(=O)N2CCC2)c1C(=O)Nc1ccn2nc(N3CCOCC3)nc2c1,,C1COCCO1,,C[Al](C)C,Cl,val
US07183300B2,C=CCNC.Nc1nc(CCl)cs1>>C=CCN(C)Cc1csc(N)n1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130289029A1,CN.COC(=O)c1ccc2c(n1)CCC1C2=NN(c2ccc(C#N)c(Cl)c2)C1C1CCCC1>>CNC(=O)c1ccc2c(n1)CCC1C2=NN(c2ccc(C#N)c(Cl)c2)C1C1CCCC1,,CCO,,,,val
US20140221345A1,CCN(C(C)C)C(C)C.COc1ccc(OCC(=O)O)cc1.NCC(O)CN1CCc2ccccc2C1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>CC(=O)Nc1ccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)cc1,,ClCCl,,,,val
US20070060573A1,CCOc1ccc(Br)cc1C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OC>>CCOc1ccc(Br)cc1C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12,,C1CCOC1,,Cl,[BH4-].[Li+],val
US07196104B2,CCOC(=O)C(=O)CBr.NC(=S)c1cc(Cl)nc(Cl)c1>>CCOC(=O)c1csc(-c2cc(Cl)nc(Cl)c2)n1,,C1COCCO1,,c1ccncc1,,val
US20160221989A1,CC(C)(C)OC(=O)N1C[C@H](Oc2cccnc2[N+](=O)[O-])C(F)(F)C1>>CC(C)(C)OC(=O)N1C[C@H](Oc2cccnc2N)C(F)(F)C1,[Pd],,,,,val
US20040092559A1,CC(C)(C)[C@H]1N(c2ccc(C#N)c3ccccc23)C(=O)[C@@H]2C[C@@H](OCc3ccccc3)CN12>>CC(C)(C)[C@H]1N(c2ccc(C#N)c3ccccc23)C(=O)[C@@H]2C[C@@H](O)CN12,,ClCCl,,ClB(Cl)Cl,,val
US20100016279A1,ClCCN1CCCC1.FC(F)(F)c1nnc2ccc(N3CCC(c4c[nH]c5ccccc45)CC3)nn12>>FC(F)(F)c1nnc2ccc(N3CCC(c4cn(CCN5CCCC5)c5ccccc45)CC3)nn12,,CN(C)C=O,,Cl,[H-].[Na+],val
US20150322008A1,COc1cc(C#N)c(Cl)c2cc[nH]c12>>N#Cc1cc(O)c2[nH]ccc2c1Cl,,ClCCl,,BrB(Br)Br,,val
US05350872,CCO.COc1ccc(CC2C(=O)OC(C)(C)OC2=O)cc1OC.O=CO>>CCOC(=O)C(Cc1ccc(OC)c(OC)c1)C(=O)O.O,,CCO,,CCN(CC)CC,,val
US20160068542A1,COc1ccc(C(=O)O)c(OC)c1.Nc1ccc(OC2CCCCO2)cc1>>COc1ccc(C(=O)Nc2ccc(OC3CCCCO3)cc2)c(OC)c1,CN(C)c1ccncc1,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20080045520A1,CCOC(=O)c1cn(C2CC2)c2cc(N3C[C@H](C)[C@H](NC(=O)OC(C)(C)C)C3)c(F)cc2c1=O>>C[C@H]1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@H]1NC(=O)OC(C)(C)C,,CCO,,Cl,[Na+].[OH-],val
US20110076292A1,Nc1cnccn1.O=Cc1ccc2c(c1)-n1nc(-c3ncnn3CC(F)(F)F)cc1CCO2>>FC(F)(F)Cn1ncnc1-c1cc2n(n1)-c1cc(CNc3cnccn3)ccc1OCC2,,CCOCC,,Cl,,val
US05223526,CCOC(=O)c1cn(C)nc1C(F)(F)F>>Cn1cc(C(=O)O)c(C(F)(F)F)n1,,CO,,[Na+].[OH-],,val
US20130178453A1,CCCI.Cc1c(C(=O)c2cc3ccccc3[nH]2)c2ccsc2n1CCN1CCOCC1>>CCCn1c(C(=O)c2c(C)n(CCN3CCOCC3)c3sccc23)cc2ccccc21,,CCOC(C)=O,CCOCC,CN(C)C=O,[H-].[Na+],val
US20090105214A1,Cc1cnc(NC(=O)c2cc(OCc3ccccc3)cc(O[C@H]3CCOC3)c2)cn1>>Cc1cnc(NC(=O)c2cc(O)cc(O[C@H]3CCOC3)c2)cn1,[Pd],C1CCOC1,CCO,,,val
US20100004233A1,CCOC(=O)C(Cc1cccc([N+](=O)[O-])c1F)C(C)=O.Oc1cccc(O)c1>>Cc1c(Cc2cccc([N+](=O)[O-])c2F)c(=O)oc2cc(O)ccc12,,O,,O=S(=O)(O)O,,val
US20070072887A1,CCOC(=O)c1oc2ccncc2c1O>>O=C1COc2ccncc21,,Cl,,,,val
US20060148858A1,CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCCO.COC(=O)Cc1cn(-c2ccccc2)nc1O>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCCOc1nn(-c2ccccc2)cc1CC(=O)O,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20100197651A1,CN(C)C=NC(=O)c1nn(-c2cccc(C(F)(F)F)c2)ccc1=O.NNc1ccccc1>>O=c1ccn(-c2cccc(C(F)(F)F)c2)nc1-c1ncnn1-c1ccccc1,,CC(=O)O,,,,val
US20100081830A1,CC(C)C(Cl)OC(=O)Cl.CSc1ccc(O)cc1>>Cc1ccc(SC(=O)OC(Cl)C(C)C)cc1,,ClCCl,,CN1CCOCC1,,val
US20080015246A1,CC(C)(C)[Si](C)(C)OCCCCBr.CCOC(=O)c1ccc(-c2ccc(O)c(-c3ccc(NCCC(C)=O)c(C(C)(C)C)c3)c2)cc1>>CCOC(=O)c1ccc(-c2ccc(OCCCCO[Si](C)(C)C(C)(C)C)c(-c3ccc(NCCC(C)=O)c(C(C)(C)C)c3)c2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120264737A1,CCOP(=S)([S-])OCC.COC(=O)c1ccc(C)c(C#N)c1>>COC(=O)c1ccc(C)c(C(N)=S)c1,,C1CCOC1,O,,,val
US06117875,CC(=O)Nc1cccc(-c2cccc(Nc3ncccc3[N+](=O)[O-])c2)c1>>Nc1cccc(-c2cccc(Nc3ncccc3[N+](=O)[O-])c2)c1,,Cl,,O=C([O-])O.[Na+],,val
US08895313B2,COc1ccc(C(=O)Cl)cc1F.Cc1ccc2nc(-c3ccc(N)cc3)cn2c1>>COc1ccc(C(=O)Nc2ccc(-c3cn4cc(C)ccc4n3)cc2)cc1F,,c1ccncc1,,,,val
US20090036443A1,C1COCCN1.COC(=O)c1cc2c(s1)c(C1CCCCC1)c(-c1ccc(Cl)cc1)n2CC(=O)O>>COC(=O)c1cc2c(s1)c(C1CCCCC1)c(-c1ccc(Cl)cc1)n2CC(=O)N1CCOCC1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US07618996B2,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)CCNCc1cc(F)c(Oc2ccc3c(c2)OC(C)(C)OC3=O)c(F)c1>>CC(C)CCN(Cc1cc(F)c(Oc2ccc3c(c2)OC(C)(C)OC3=O)c(F)c1)C(=O)OC(C)(C)C,,CCOC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20140256736A1,CC(=O)Cl.COc1ccc(CN(c2ncns2)S(=O)(=O)c2cc(F)c(Oc3ccc(Cl)cc3-c3ccc4onc(NC(=O)OC(C)(C)C)c4c3)cc2F)c(OC)c1>>COc1ccc(CN(c2ncns2)S(=O)(=O)c2cc(F)c(Oc3ccc(Cl)cc3-c3ccc4onc(N(C(C)=O)C(=O)OC(C)(C)C)c4c3)cc2F)c(OC)c1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20060128689A1,BrCc1ccccc1.CC(C)(C)OC(=O)NC1CNc2ccccc2C1>>CC(C)(C)OC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20130274255A1,NN.O=C(c1cccc(Br)c1)C1Cc2sccc2C1=O>>Brc1cccc(-c2n[nH]c3c2Cc2sccc2-3)c1,,CCO,,CC(=O)O,O,val
US20130053345A1,CC(C)(C)OC(=O)N1CCC(CC(=O)O)CC1.Nc1ccc(Br)cc1O>>CC(C)(C)OC(=O)N1CCC(CC(=O)Nc2ccc(Br)cc2O)CC1,,CC#N,,ClCCCl,,val
US20090325981A1,COC(=O)c1cccc(-c2nc3c(C4SC(c5ccc(F)c(F)c5)=NN4C(=O)c4c(F)cc(F)cc4F)cccc3o2)c1>>O=C(O)c1cccc(-c2nc3c(C4SC(c5ccc(F)c(F)c5)=NN4C(=O)c4c(F)cc(F)cc4F)cccc3o2)c1,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US20100093703A1,O=C(COCCCl)Nc1cnc(Br)cn1>>O=C1COCCN1c1cnc(Br)cn1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090163512A1,CCC(CC)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(Cl)ccc2C)C12C(=O)N(C(C)=O)c1cc(Cl)ccc12)C(=O)NS(C)(=O)=O>>CCC(CC)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(Cl)ccc2C)C12C(=O)Nc1cc(Cl)ccc12)C(=O)NS(C)(=O)=O,,CO,,O,[Na+].[OH-],val
US20150344481A1,NC1CC1.O=CC(=O)O.[C-]#[N+]C(c1ccc(F)cc1)S(=O)(=O)c1ccc(C)cc1>>Fc1ccc(-c2cn(C3CC3)cn2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20130102776A1,C#Cc1ccc2cc[nH]c2n1.C1N2CN3CN1CN(C2)C3.O=C([O-])O>>C#Cc1ccc2c(C=O)c[nH]c2n1,,O,,CC(=O)O,,val
US07179823B1,CCOC(=O)CCc1cn(Cc2ccc(O)cc2)cc1-c1ccccc1.OCc1ccoc1>>CCOC(=O)CCc1cn(Cc2ccc(OCc3ccoc3)cc2)cc1-c1ccccc1,,C1CCOC1,Cc1ccccc1,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06713471B1,CC(C)(C)OC(=O)N1CC[C@H]2[C@@H](C1)c1cc(-c3ccccc3Cl)cc3c1N2CCO3>>Clc1ccccc1-c1cc2c3c(c1)[C@H]1C=NCC[C@@H]1N3CCO2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030220350A1,Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(Cl)Oc1ccccc1>>O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Oc1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160272631A1,O=C(NCc1ncccn1)C(=O)c1c(Cl)cccc1Cl>>O=C(c1c(Cl)cccc1Cl)c1ncc2ncccn12,,O=P(Cl)(Cl)Cl,,,,val
US20130281431A1,COc1ccccc1C(C)CN.Clc1cc(Cl)ncn1>>COc1ccccc1C(C)CNc1cc(Cl)ncn1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US06093718,CC(C)(C)OC(=O)N1CCN(c2cc(Cl)ncn2)CC1.Cl>>Cl.Clc1cc(N2CCNCC2)ncn1,,CCOC(C)=O,,,,val
US20050054670A1,CC(C)(C)c1ccc(N)cc1.COC(=O)c1c(Br)cccc1CBr>>CC(C)(C)c1ccc(N2Cc3cccc(Br)c3C2=O)cc1,,CC(C)O,,,,val
US20160222005A1,CC(C)(C)OC(=O)N1CCC(c2cnc3[nH]c(-c4ccc(OCc5ccccc5)c(Br)c4)nc3c2)CC1>>Brc1cc(-c2nc3cc(C4CCNCC4)cnc3[nH]2)ccc1OCc1ccccc1,,O=C(O)C(F)(F)F,,ClCCl,,val
US20080193411A1,Nc1ccc(Br)cc1.O=C(Cl)C1CC1>>O=C(Nc1ccc(Br)cc1)C1CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130096113A1,CSc1nc2ccc(Cn3cnc4cc(C)c(C)cc43)cc2s1.O=C(OO)c1cccc(Cl)c1>>Cc1cc2ncn(Cc3ccc4nc(S(C)=O)sc4c3)c2cc1C,,CCOC(C)=O,ClCCl,,,val
US04243408,CNC(=S)NNC(=O)CNc1c(C)cccc1C>>Cc1cccc(C)c1NCc1nnc(S)n1C,,CCO,,O,[Na+].[OH-],val
US20040254185A1,N#Cc1ccc(CNc2ccccc2C(=O)Nc2ccc3c(c2)CC(=O)N3)cn1.OO>>NC(=O)c1ccc(CNc2ccccc2C(=O)Nc2ccc3c(c2)CC(=O)N3)cn1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100004284A1,Fc1cccc(Oc2noc([C@H]3CCCNC3)n2)c1.O=C(Cl)c1ccc(F)cc1>>O=C(c1ccc(F)cc1)N1CCC[C@H](c2nc(Oc3cccc(F)c3)no2)C1,,ClCCl,,CCN(CC)CC,Cl,val
US20050153957A1,CC(=O)c1ccc2c(c1)CC(C)(NC(=O)c1ccccc1)C2>>CCc1ccc2c(c1)CC(C)(NC(=O)c1ccccc1)C2,[Pd],CCO,Cl,,,val
US20090286811A1,COc1cccc(/C=C/c2cc(=O)n3c(C)c(C)sc3n2)c1OCC1CC1.O=C1CCC(=O)N1I>>COc1cccc(/C=C/c2nc3sc(C)c(C)n3c(=O)c2I)c1OCC1CC1,,CC#N,,,,val
US20130303492A1,CSC(Nc1ccc(N2CCN(C(C)C)CC2)cc1)=C(C#N)C(N)=O.NN>>CC(C)N1CCN(c2ccc(Nc3n[nH]c(N)c3C(N)=O)cc2)CC1,,CCO,,O,,val
US05202318,CC=O.Nc1c(Cl)cc2c3c(cccc13)C(=O)N(C1CCNCC1)C2=O>>CCN1CCC(N2C(=O)c3cccc4c(N)c(Cl)cc(c34)C2=O)CC1,,CO,O,Cl,[BH3-]C#N.[Na+],val
US20140088101A1,COC(=O)c1ncc2c(cc(-c3cccc(C(F)(F)F)c3)c(=O)n2Cc2ccccc2)c1O.O=C1CCC(=O)N1Br>>COC(=O)c1nc(Br)c2c(cc(-c3cccc(C(F)(F)F)c3)c(=O)n2Cc2ccccc2)c1O,,ClCCl,,,,val
US05037824,Cc1cc(-c2cccc(C#N)c2)c(C(=O)OCc2ccccc2)c(C)n1>>Cc1cc(-c2cccc(C#N)c2)c(C(=O)O)c(C)n1,[Pd],C1CCOC1,CCO,[H][H],,val
US20120172351A1,COC(=O)c1cccc(Nc2ccc(Cl)cc2NC(=O)[C@H]2CCCO2)c1C>>COC(=O)c1cccc(-n2c([C@H]3CCCO3)nc3cc(Cl)ccc32)c1C,,O,,,,val
US05300503,CC1(C)N=C(N)N=C(N)N1O>>CC1(C)N=C(N)N=C(N)N1O,,O,,Cl,,val
US20070254866A1,COc1c(F)c(F)c(N)c2c(=O)c(C(=O)O)c[nH]c12.NCCNc1ccccn1>>COc1c(NCCNc2ccccn2)c(F)c(N)c2c(=O)c(C(=O)O)c[nH]c12,,CS(C)=O,,CCN(CC)CC,,val
US20040024230A1,CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C>>CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)C=C[C@]4(C)[C@H]3CC[C@@]21C,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20150018363A1,CCOC(=O)c1nc2ccc(I)cn2c1C>>Cc1c(C=O)nc2ccc(I)cn12,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US04788186,COc1ccc(-c2nnc3c4ccccc4c(O)nn23)cc1.O=C1NCCC1Br>>COc1ccc(-c2nnc3c4ccccc4c(OC4CCNC4=O)nn23)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20030013875A1,CCCCCCC1C(=O)C2N(C1=O)C2(C)c1ccccc1[N+](=O)[O-]>>CCCCCCC1C(=O)C2N(C1=O)C2(C)c1ccccc1N,[Pd],C1CCOC1,,,,val
US20150329538A1,CCOC(=O)/C=C/CNC(=O)c1cc(Br)c[nH]1>>CCOC(=O)CC1CNC(=O)c2cc(Br)cn21,,CC#N,,C1CCC2=NCCCN2CC1,,val
US05677303,CCOC(=O)CP(=O)(OCC)OCC.COc1ccc(C=O)cc1OC>>CCOC(=O)C=Cc1ccc(OC)c(OC)c1,,C1CCOC1,,[H-].[Na+],,val
US20120003273A1,COc1ccccc1-c1coc2cc(O)ccc2c1=O>>O=c1c(-c2ccccc2O)coc2cc(O)ccc12,,ClCCl,,BrB(Br)Br,,val
US20080132528A1,C=CCc1cc(C(=O)OC)ccc1C.NN>>C=CCc1cc(C(=O)NN)ccc1C,,CCO,,O,,val
US20070179297A1,COC(=O)c1cc(C#N)c(S(C)(=O)=O)s1.O>>CS(=O)(=O)c1sc(C(=O)O)cc1C(N)=O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20140031342A1,CC(C)(C)OC(=O)N1CCC(Cc2ccc(OCc3ccc(C(F)(F)F)cc3)cc2)CC1>>FC(F)(F)c1ccc(COc2ccc(CC3CCNCC3)cc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100217012A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=[N+]([O-])c1ccc2c(c1)O[C@@H](CO)CO2>>Cc1ccc(S(=O)(=O)OC[C@H]2COc3ccc([N+](=O)[O-])cc3O2)cc1,,c1ccncc1,,O,,val
US20140221333A1,NCc1nccnc1Cl.O=C(O)C1CCC(C(F)(F)F)N(C(=O)OCc2ccccc2)C1>>O=C(NCc1nccnc1Cl)C1CCC(C(F)(F)F)N(C(=O)OCc2ccccc2)C1,,ClCCl,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050075378A1,Cc1oc(-c2ccccc2)nc1CCOc1ccc(CCC(=O)OC(C)(C)C)c(C(=O)OCC[Si](C)(C)C)c1>>CC(C)(C)OC(=O)C=Cc1ccc(OCc2ccccc2)cc1C=O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130029987A1,CCOC(=O)c1cnc(SC)nc1N[C@@H]1CCC[C@@H]1CO>>CSc1ncc(C(=O)O)c(N[C@@H]2CCC[C@@H]2CO)n1,,CCO,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US20140213586A1,COc1cccc(N)c1.N#Cc1cc(F)c(C=O)c(F)c1>>COc1cccc(N=Cc2c(F)cc(C#N)cc2F)c1,,CCO,,,,val
US20080032963A1,Cc1cc(Nc2cc(N3CCC3)nc(Sc3ccc(N)cc3)n2)[nH]n1.Cc1cccc(C(=O)Cl)c1>>Cc1cccc(C(=O)Nc2ccc(Sc3nc(Nc4cc(C)n[nH]4)cc(N4CCC4)n3)cc2)c1,,c1ccncc1,,,,val
US20120184542A1,CNCc1cccc(Cl)c1.COc1ncc2cc(C(=O)Nc3cc(C(=O)O)ccc3C)c(=O)[nH]c2n1>>COc1ncc2cc(C(=O)Nc3cc(C(=O)N(C)Cc4cccc(Cl)c4)ccc3C)c(=O)[nH]c2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05258380,Fc1ccc(Cn2c(NC3CCNCC3)nc3cncnc32)cc1.N#CCCl>>N#CCN1CCC(Nc2nc3cncnc3n2Cc2ccc(F)cc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20160016948A1,CC1(C)OB(c2cn[nH]c2)OC1(C)C.CNC(=O)C(C)(C)Br>>CNC(=O)C(C)(C)n1cc(B2OC(C)(C)C(C)(C)O2)cn1,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US06087380,CCCCCCOC(=O)Cl.CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C)c1ccccc1>>CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccc4)ccc3n2C)cc1,,C1CCOC1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20140315886A1,CC(C)CC(=O)Cl.COc1ccc2nc(-c3cccnc3)nc(N3CCc4cc(N)ccc43)c2c1>>COc1ccc2nc(-c3cccnc3)nc(N3CCc4cc(NC(=O)CC(C)C)ccc43)c2c1,,ClCCl,O,c1ccncc1,,val
US06686353B1,ClCc1ccc2ccccc2n1.c1ccc(C(CCN2CCCNCC2)c2ccccc2)cc1>>c1ccc(C(CCN2CCCN(Cc3ccc4ccccc4n3)CC2)c2ccccc2)cc1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120022080A1,CC(C)(C)c1cccc(O)c1.COC(=O)c1cc(Cl)ccc1NC(=O)CCl>>COC(=O)c1cc(Cl)ccc1NC(=O)COc1cccc(C(C)(C)C)c1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110311474A1,CC[C@@H]1C[C@H](NS(=O)(=O)C2CC2)C[C@@H]1N=C=O.Cc1ccc(S(=O)(=O)n2ccc3c(Cl)c(CCC=O)cnc32)cc1>>CC[C@@H]1C[C@H](NS(=O)(=O)C2CC2)C[C@@H]1NCCCc1cnc2c(ccn2S(=O)(=O)c2ccc(C)cc2)c1Cl,,ClCCCl,ClCCl,CC(=O)O,O=C([O-])O.[Na+],val
US20080015203A1,COC[C@@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)OC)c1>>COC[C@@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)O)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20080058302A1,CC1(C)C(NC(=O)c2ccc(Br)c(S(=O)(=O)N3CCOCC3)c2)[C@@]2(C)CC[C@@H]1C2.OCc1ccccc1>>CC1(C)C(NC(=O)c2ccc(OCc3ccccc3)c(S(=O)(=O)N3CCOCC3)c2)[C@@]2(C)CC[C@@H]1C2,,CN(C)C=O,,CCOC(C)=O,,val
US05948819,CCI.Cc1ccc(C)c(OCc2ccccc2CC#N)c1>>CCC(C#N)c1ccccc1COc1cc(C)ccc1C,,CN(C)C=O,,O,[H-].[Na+],val
US06593314B1,C=C[C@@H]1C[C@](O)(C(=O)OC)C[C@@H](OC(=O)c2ccccc2)[C@H]1O>>C=C[C@@H]1C[C@](O)(C(=O)OC)C[C@@H](O)[C@H]1O,,CO,,O=C([O-])[O-].[K+].[K+],,val
US05556864,CN1CCCC1CCCl.Cc1ccccc1CCc1ccccc1O>>Cc1ccccc1CCc1ccccc1OCCC1CCCN1C,,CC(=O)N(C)C,,Cl,CC(C)(C)[O-].[K+],val
US20100081691A1,C1CNCCN1.CCN(C(C)C)C(C)C.CN(C)C=O.O=C(O)c1cccnc1Cl.On1nnc2ccccc21>>O=C(c1ccc(Cl)nc1)N1CCN(c2ncccn2)CC1,,CCOC(C)=O,O,,,val
US20030199478A1,CCNCC.O=C1Nc2ccccc2C1=CNc1ccc(OCCCCI)cc1>>CCN(CC)CCCCOc1ccc(NC=C2C(=O)Nc3ccccc32)cc1,,CO,,,,val
US04237054,CC(=O)OC/C=C1\CCC(OC(C)=O)C(C)(CCCC(C)COC2CCCCO2)OC1>>CC(CCCC1(C)OC/C(=C/CO)CCC1O)COC1CCCCO1,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US05532266,CN(C(=O)C(c1ccccc1)c1ccccc1)[C@H](CN1CC[C@H](O)C1)c1ccc(OCc2ccccc2)cc1>>CN(C(=O)C(c1ccccc1)c1ccccc1)[C@H](CN1CC[C@H](O)C1)c1ccc(O)cc1,[Pd],CCOC(C)=O,,[H][H],,val
US20160090381A1,Cn1cc(C2CCNCC2)c2c(C(F)(F)F)c(NC(=O)c3cccc(C#N)c3)cnc21.O=C(O)CC1CCCC1>>Cn1cc(C2CCN(C(=O)CC3CCCC3)CC2)c2c(C(F)(F)F)c(NC(=O)c3cccc(C#N)c3)cnc21,,ClCCl,,Cl,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070287711A1,C1COCCN1.COc1ccccc1-c1n[nH]c2ncc(-c3cc(F)c(NC4CCC(=O)CC4)c(C(=O)N(C)C)c3)cc12>>COc1ccccc1-c1n[nH]c2ncc(-c3cc(F)c(NC4CCC(N5CCOCC5)CC4)c(C(=O)N(C)C)c3)cc12,,CO,O,CC(=O)O,[BH3-]C#N.[Na+],val
US04150131,CCOC(=O)Nc1cc(N2CC3CCC(CC3)C2)nc(NC(=O)OCC)[n+]1[O-]>>CCOC(=O)Nc1cc(N2CC3CCC(CC3)C2)nc2nc(=O)on12,,CN(C)C=O,,,,val
US04973735,CCOc1ccc(C(C(=O)Cl)C(C)(C)C)cc1F.OCC(F)(F)F>>CCOc1ccc(C(C(=O)OCC(F)(F)F)C(C)(C)C)cc1F,CN(C)c1ccncc1,c1ccncc1,,,,val
US20150087639A1,CN1CCN(c2ccc(N)cc2F)CC1.COC(=O)/C=C(/C)NC(=O)COc1cccc(F)c1>>Cc1cc(=O)n(-c2ccc(N3CCN(C)CC3)c(F)c2)c(COc2cccc(F)c2)n1,,ClCCl,,C[Al](C)C,,val
US04963568,BrB(Br)Br.COc1ccc2c(c1OC)C[C@@H](C1CCCCC1)C[C@H]2CN>>Br.NC[C@@H]1C[C@H](C2CCCCC2)Cc2c1ccc(O)c2O,,ClCCl,,CO,Cl,val
US20120077799A1,Cc1ccc(C(F)(F)c2ccc(C3=CC=CN4CCS(=O)(=O)N=C34)cc2)cc1>>Cc1ccc(C(F)(F)c2ccc(C3CCCN4CCS(=O)(=O)N=C34)cc2)cc1,O=[Pt]=O,C1CCOC1,CO,,,val
US04847294,C1CO1.O=C1NS(=O)(=O)c2cccc([N+](=O)[O-])c21>>O=C1c2c([N+](=O)[O-])cccc2S(=O)(=O)N1CCO,,O,,,,val
US20160095844A1,CCc1cn(-c2ccc3c(c2)N(COCC[Si](C)(C)C)C(=O)C3(C)C)cn1>>CCc1cn(-c2ccc3c(c2)NC(=O)C3(C)C)cn1,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US20090131458A1,CCCCOc1nc(N)c2nc(OC)n(CCCC3CCOC3)c2n1>>CCCCOc1nc(N)c2[nH]c(=O)n(CCCC3CCOC3)c2n1,,C1COCCO1,CO,Cl,[Na+].[OH-],val
US04520030,Br.CCCN(CCC)C1CCc2c(ccc(O)c2N)C1.O=CO>>Br.CCCN(CCC)C1CCc2c(ccc(O)c2NC=O)C1,,CCOCC,,CC(=O)OC(C)=O,,val
US20110098320A1,C[C@@H](c1ccc(Br)cc1)N1CC[C@@](CCO)(c2ccccc2)CC1=O.OB(O)c1ccc(F)cc1>>C[C@@H](c1ccc(-c2ccc(F)cc2)cc1)N1CC[C@@](CCO)(c2ccccc2)CC1=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04493843,CCCCCCCCCC(=O)Cl.Cc1ccc(C(=O)O)cc1N>>CCCCCCCCCC(=O)Nc1cc(C(=O)O)ccc1C,,CN(C)C=O,,O,,val
US20090163714A1,Clc1ncnc2[nH]ncc12.Fc1ccc(-c2cnc(N3CCNCC3)[nH]2)cc1C(F)(F)F>>Fc1ccc(-c2cnc(N3CCN(c4ncnc5[nH]ncc45)CC3)[nH]2)cc1C(F)(F)F,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20080269208A1,O=C1N[C@@H](CO)C(=O)N2CCOCC12>>OC[C@H]1CN2CCOCC2CN1,,CO,,Cl,,val
US20050004167A1,NN.O=C(O)c1ccc2oc3ccccc3c2c1>>NNC(=O)c1ccc2oc3ccccc3c2c1,,CCOC(C)=O,CN(C)C=O,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20100184740A1,Cc1cc([N+](=O)[O-])ccc1-n1cccc(CCCO)c1=O>>Cc1cc(N)ccc1-n1cccc(CCCO)c1=O,[Pd],C1CCOC1,,[H][H],,val
US20030069257A1,O=[N+]([O-])O.[O-][n+]1cccc(Cl)c1>>O=[N+]([O-])c1cc[n+]([O-])cc1Cl,,O=S(=O)(O)O,,,,val
US20150031693A1,C[Si](C)(C)Cl.NCCCO>>C[Si](C)(C)OCCCN,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20070003539A1,CCc1cc(OC)c(F)c(C(O)C#N)c1.CO.Cl>>CCc1cc(OC)c(F)c(C(O)C(=N)OC)c1.Cl,,C1COCCO1,CCOCC,,,val
US20100130556A1,N=C(Nc1cccc(C2OCCCO2)c1)c1cc(-c2ccccc2)ccc1F>>N=C(Nc1cccc(C=O)c1)c1cc(-c2ccccc2)ccc1F,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20100179172A1,N#C[Cu]C#N.Nc1cc(C(F)(F)F)c(Br)c(C(F)(F)F)c1>>N#Cc1c(C(F)(F)F)cc(N)cc1C(F)(F)F,,CN(C)P(=O)(N(C)C)N(C)C,,CCOC(C)=O,O,val
US08324425B2,CCC1=C[C@@H]2[C@H](C1)C[C@]2(CN)CC(=O)OC(C)(C)C>>CCC1=C[C@@H]2[C@H](C1)C[C@]2(CN)CC(=O)OC(C)(C)C,,CCOC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120172391A1,CI.O=C(O)c1ncc(COc2ccccc2)cc1Cl>>COC(=O)c1ncc(COc2ccccc2)cc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US03962325,CC(C)=CCCl.O=C(F)C(C(=O)F)C(F)(F)F>>CC(C)=CCC(C(=O)F)(C(=O)F)C(F)(F)F,,CCOCC,,CCN(CC)CC,,val
US20110224262A1,N#CCBr.O=C1CC(c2ccccc2)=NN1>>N#CCOc1cc(-c2ccccc2)n[nH]1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04521430,CCN(C)CCN1C(=O)[C@H](O)[C@H](c2ccc(OC)cc2)Sc2ccccc21.O=C(Cl)c1ccc([N+](=O)[O-])cc1Cl.O=C([O-])C(=O)[O-]>>CCN(C)CCN1C(=O)[C@H](OC(=O)c2ccc([N+](=O)[O-])cc2Cl)[C@H](c2ccc(OC)cc2)Sc2ccccc21.O=C(O)C(=O)O,,ClCCl,,CCN(CC)CC,Cl,val
US20070072896A1,Cn1cc(-c2c[nH]c3ncc(C(=O)N4CCc5ccccc54)cc23)cn1>>Cn1cc(-c2c[nH]c3ncc(CN4CCc5ccccc54)cc23)cn1,,C1CCOC1,,,,val
US20110263598A1,BrCc1ccccc1.Cc1ccc2c(c1)C(=O)C(=O)N2>>Cc1ccc2c(c1)C(=O)C(=O)N2Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050239841A1,COc1ccc([C@@]23CC[C@@H](N)C[C@@H]2N(C)CC3)cc1OC.COc1ncccc1N=C(NC#N)Oc1ccccc1>>COc1ccc([C@@]23CC[C@@H](NC(=Nc4cccnc4OC)NC#N)C[C@@H]2N(C)CC3)cc1OC,,CN(C)C=O,ClCCl,,,val
US20160222006A1,C#Cc1ccc(-n2c(/C=C/c3cc(OC)c(OC)c(OC)c3)nc3ncccc3c2=O)cc1.CC(=O)O>>C#Cc1ccc(N2C(=O)c3cccnc3NC2(C)C)cc1,,CC(=O)O,,O=C([O-])O.[Na+],,val
US20100221796A1,CC(=O)Cl.CCCOC(=O)[C@@H](N)CO.Cl>>CCCOC(=O)[C@H](CCl)NC(C)=O,,Cc1ccccc1,,O=S(Cl)Cl,,val
US20120077795A1,C=C(C)CI.C[C@@H](NCC#N)c1ccccc1>>C=C(C)CN(CC#N)[C@H](C)c1ccccc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05534537,CNC(C(=O)OC(C)(C)C)c1cccc(C(=O)N[C@@H](CCSC)C(=O)OC)c1.O=C(O)C(F)(F)F>>CNCc1cccc(C(=O)N[C@@H](CCSC)C(=O)OC)c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20090076004A1,CCOC(=O)Cc1c(C(=O)OCC)c2cc(O)ccc2n1-c1ccc(C(C)C)cc1.OB(O)c1cccc(C(F)(F)F)c1>>CCOC(=O)Cc1c(C(=O)OCC)c2cc(Oc3cccc(C(F)(F)F)c3)ccc2n1-c1ccc(C(C)C)cc1,,c1ccncc1,,,,val
US20040106599A1,Nc1ccccc1NC(=O)c1ccc(C=C2Cc3ccccc3C2=O)cc1>>Nc1ccccc1NC(=O)c1ccc(CC2Cc3ccccc3C2O)cc1,,CO,O,[BH4-].[Na+],,val
US20160046616A1,O=[N+]([O-])c1ccccc1S(=O)(=O)Cl.c1ccc2c(c1)CCN2>>O=[N+]([O-])c1ccccc1S(=O)(=O)N1CCc2ccccc21,,ClCCl,O,CCN(CC)CC,,val
US04778812,Cc1c2n(c3ccccc13)CC(C)(C)C2=O>>Cc1c2n(c3ccccc13)CC(C)(C)C2O,,CO,,[BH4-].[Na+],,val
US20150274624A1,CC(C)(C)C(=O)Cl.OCCOc1ccccc1>>CC(C)(C)C(=O)OCCOc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20160016961A1,CC(C)(C)NS(=O)(=O)c1cncc(-c2cc(NCc3ccccc3)c3c(-c4ccccc4)ccn3n2)c1>>NS(=O)(=O)c1cncc(-c2cc(NCc3ccccc3)c3c(-c4ccccc4)ccn3n2)c1,,CC#N,,O=S(=O)(O)C(F)(F)F,,val
US20080021043A1,C=CCc1ccc([C@@H](CCC(C)C)N2CC[C@@H](C(C)C(=O)[O-])C[C@H]2c2ccc(C(F)(F)F)cc2)cc1>>C=CCc1ccc([C@@H](CCC(C)C)N2CC[C@@H](CC(=O)O)C[C@H]2c2ccc(C(F)(F)F)cc2)cc1,,CO,,[Na+].[OH-],,val
US20150031708A1,COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1C.Cc1ccc(NC(=O)C2(c3ccc4c(c3)CCO4)CC2)nc1Cl>>COc1ncc(-c2nc(NC(=O)C3(c4ccc5c(c4)CCO5)CC3)ccc2C)cc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US05747518,O=[N+]([O-])c1ccsc1-c1ccc(Cl)cc1>>Nc1ccsc1-c1ccc(Cl)cc1,[Fe],CC(=O)O,,,,val
US20070287715A1,BrC1CCCC1.O=c1ccc(Br)c[nH]1>>Brc1ccc(OC2CCCC2)nc1,,Cc1ccccc1,,,,val
US05028610,CC1(C)CN(C(c2ccc(F)cc2)c2ccc(F)cc2)CCN1.O=C(CCl)Nc1cccc(F)c1>>CC1(C)CN(C(c2ccc(F)cc2)c2ccc(F)cc2)CCN1CC(=O)Nc1cccc(F)c1,,C1CCOC1,CN(C)C=O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20040204398A1,C1CNCCN1.CC(C)(C)N1C[C@@H](c2ccc(F)cc2F)[C@H](C(=O)O)C1.CN1CCOCC1.ClCCCl.ClCCl.On1nnc2ccccc21>>CCN(CC)CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1,,ClCCl,,Cl,,val
US20120208852A1,CC(C)(C)OC(=O)NC(C(=O)NN)c1cccc(C(F)(F)F)c1.N#CBr>>CC(C)(C)OC(=O)NC(c1cccc(C(F)(F)F)c1)c1nnc(N)o1,,CO,,,,val
US20120028919A1,CCOC(=O)c1ccccc1-c1ccc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nn12>>CN1CCN(c2ccc(Nc3ncc4ccc(-c5ccccc5C(=O)O)n4n3)cc2)CC1,,O,,CO,[Li+].[OH-],val
US20070293477A1,CC1(O)CCCN(C(=O)OC(C)(C)C)CC1>>CC1(O)CCCNCC1,,ClCCl,,Cl,,val
US20090227591A1,BrBr.Oc1ccc(Cl)cn1>>O=c1[nH]cc(Cl)cc1Br,,CC(=O)O,,CCOC(C)=O,O,val
US20080153852A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(-c2cc(Cl)nc(N)n2)cc1)C(=O)O.COc1ccc(-n2cc(C)cn2)c(C(O)C(F)(F)F)c1>>COc1ccc(-n2cc(C)cn2)c(C(Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)c1,,ClCCl,O=C(O)C(F)(F)F,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US20110263603A1,CC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1C.NO>>CC(=NO)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1C,CC(=O)O,CO,,Cl,,val
US20110028507A1,CCOC(=O)C1C(=O)C2Sc3ccccc3C2CN1Cc1ccc(OC)cc1OC>>CCOC(=O)c1ncc2c(sc3ccccc32)c1O,,ClCCl,,O=S(Cl)Cl,O=C([O-])O.[Na+],val
US20050096306A1,CC(C)(C)OC(=O)NC(=NS(=O)(=O)C(F)(F)F)NC(=O)OC(C)(C)C.Cn1ncc(NC(=O)[C@H](CNC(=O)OC(C)(C)C)NC(=O)OCc2ccccc2)c1N>>Cn1ncc(NC(=O)[C@H](CNC(=O)OC(C)(C)C)NC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)c1N,[Pd],C1CCOC1,,CCN(CC)CC,O,val
US20120172291A1,CCOC(=O)C(=O)c1cc2ccccc2o1.Nc1ccccc1N>>Oc1nc2ccccc2nc1-c1cc2ccccc2o1,,CCO,,,,val
US04310526,CCCc1c(/C=C/c2ccccc2C)nc2ccc(C(=O)O)cn2c1=O.CCN(CC)CCCl>>CCCc1c(/C=C/c2ccccc2C)nc2ccc(C(=O)OCCN(CC)CC)cn2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120035134A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.OCCN1CCNCC1>>CC(C)(C)[Si](OCCN1CCNCC1)(c1ccccc1)c1ccccc1,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20040220235A1,COC(=O)c1ccccc1Nc1ccc(CCCc2ccc(Cl)c(Cl)c2)cc1>>O=C(O)c1ccccc1Nc1ccc(CCCc2ccc(Cl)c(Cl)c2)cc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20050282875A1,CN1CC[C@@H](O)C1.COC(=O)C(O)(c1cccs1)c1cccs1>>CN1CC[C@@H](OC(=O)C(O)(c2cccs2)c2cccs2)C1,,Cc1ccccc1,,,,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4c(Br)cccc4nn23)CC1.Cl>>Cl.O=c1cc(C2CCNCC2)n2nc3cccc(Br)c3c2[nH]1,,C1COCCO1,,,,val
US20090240057A1,O=C(Cl)c1ccccc1.OCc1snc(Cl)c1Cl>>O=C(OCc1snc(Cl)c1Cl)c1ccccc1,,Cc1ccccc1,,CCN(CC)CC,O,val
US20040138277A1,CCOC(=O)C(C)(Cc1ccc(OCc2ccccc2)cc1)Oc1cccc(F)c1>>CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1cccc(F)c1,[Pd],CCOC(C)=O,,,,val
US20160083391A1,CC(C)(C)OC(=O)N(CCO)Cc1nc2c(cnn2C2CCCC2)c(=O)[nH]1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N(CCOS(C)(=O)=O)Cc1nc2c(cnn2C2CCCC2)c(=O)[nH]1,,ClCCl,,CCN(CC)CC,,val
US20030191118A1,COC(=O)c1c(Cl)cc(N)cc1Cl.O=N[O-]>>COC(=O)c1c(Cl)cc(O)cc1Cl,,Cl,,O,,val
US20100135999A1,CCOC(=O)N1CCN(C(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)c2cc(O)c3ccc(C)cc3n2)CC1.O=C(CBr)OCc1ccccc1>>CCOC(=O)N1CCN(C(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)OCc3ccccc3)c3ccc(C)cc3n2)CC1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040053956A1,CC(=O)N1CCc2ccc(S(=O)(=O)n3ccc4ccccc43)cc2C1.Cl>>Cl.O=S(=O)(c1ccc2c(c1)CNCC2)n1ccc2ccccc21,,CCCCO,,,,val
US04776929,COC(=O)[O-].C[N+](C)(C)Cc1ccccc1>>C[N+](C)(C)Cc1ccccc1.O=C([O-])O,,O,,,,val
US20040138255A1,FC(F)(F)Sc1ccc(C#Cc2ccc(SC(F)(F)F)cc2)cc1>>FC(F)(F)Sc1ccc(CCc2ccc(SC(F)(F)F)cc2)cc1,[Pd],CCCCCC,,,,val
US06251890B1,C=CCOC(=O)O[C@H](C)[C@H]1C(=O)N2C(C(=O)OCC=C)=C(CO)[C@H](C)[C@H]12.O=S1(=O)Nc2ccc3c4c(ccc1c24)CNC3>>C=CCOC(=O)O[C@H](C)[C@H]1C(=O)N2C(C(=O)OCC=C)=C(CN3c4ccc5c6c(ccc(c46)S3(=O)=O)CNC5)[C@H](C)[C@H]12,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100331305A1,CC1(C)OCc2c(Cl)nc(Cl)nc21.C[C@H]1COCCN1>>C[C@H]1COCCN1c1nc(Cl)nc2c1COC2(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,[Cl-].[NH4+],val
US05654294,C1CCC(NC2CCCCC2)CC1.CCOC(C)=O.ClCCl.O=C(NC1CCC(=O)N2CCCC(C(=O)O)N2C1=O)C(S)Cc1ccccc1>>COC(=O)CN1C(=O)C(NC(=O)[C@H](Cc2ccccc2)SC(C)=O)CCCC12CCC2,,ClCCl,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20050101617A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1ccco1>>CC(C)(C)OC(=O)NCc1ccco1,,ClCCl,,,,val
US20090023725A1,CC(C)(C)OC(=O)NN=C(c1cnccn1)c1ccc(Br)cc1F>>Brc1ccc2c(-c3cnccn3)n[nH]c2c1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20040167118A1,CC(C)OC(=O)Cl.NCC(=O)N1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1>>CC(C)OC(=O)NCC(=O)N1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US20120270857A1,COC(=O)c1cccc2nc(-c3ccc(F)cc3)n(CC(OC)OC)c12>>COC(=O)c1cccc2nc(-c3ccc(F)cc3)n(CC=O)c12,,ClCCCl,,O,O=C(O)C(F)(F)F,val
US05204344,COC(=O)C(C)(C)Cc1c(Cc2ccc(Cl)cc2)c2ccc(OC(=O)c3ccc(Cl)cc3)cc2n1C>>COC(=O)C(C)(C)Cc1c(Cc2ccc(Cl)cc2)c2ccc(O)cc2n1C,,CO,,C[O-].[Na+],,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4c(C#N)cccc4nn23)CC1.O=C(O)C(F)(F)F>>N#Cc1cccc2nn3c(C4CCNCC4)cc(=O)[nH]c3c12.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20090227619A1,CCOC(=O)c1cc2c(cn1)[nH]c1ccccc12>>O=C(O)c1cc2c(cn1)[nH]c1ccccc12,,O,,CCO,[Na+].[OH-],val
US20060217562A1,CCN(CC)S(F)(F)F.N#Cc1nn(Cc2ccccc2)c2c1CC(O)C2>>N#Cc1nn(Cc2ccccc2)c2c1CC(F)C2,,CCOC(C)=O,ClCCl,,,val
US04348264,CC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1.Cc1onc(-c2ccccc2)c1C(=O)Cl>>CC1=C(C(=O)O)N2C(=O)C(NC(=O)c3conc3-c3cccc(C)c3)[C@H]2SC1,,CC(C)=O,,O,O=C([O-])O.[Na+],val
US20070238715A1,O=C(O)c1ccc(O)c(C(F)(F)F)c1.O=S(=O)(Cl)Cl>>O=C(O)c1cc(Cl)c(O)c(C(F)(F)F)c1,,O,,CC(=O)O,,val
US05334716,CCOC(=O)CC/C=C/c1ccccn1>>CCOC(=O)CCCCc1ccccn1,[Pd],CCO,,,,val
US20140038990A1,Br[Mg]CC1CCCCC1.COC(=O)c1nc(S(C)(=O)=O)n(C)c(=O)c1OCc1ccccc1>>COC(=O)c1nc(CC2CCCCC2)n(C)c(=O)c1OCc1ccccc1,,C1CCOC1,,,,val
US20070275968A1,Cc1cccc(-c2nn(COCC[Si](C)(C)C)cc2-c2ccc(F)c(-c3cn(C)cn3)c2)n1>>Cc1cccc(-c2n[nH]cc2-c2ccc(F)c(-c3cn(C)cn3)c2)n1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20120129843A1,C1CN(C2CC2)CCN1.CC(=O)c1ccc(Cl)nc1>>CC(=O)c1ccc(N2CCN(C3CC3)CC2)nc1,,CCOC(C)=O,,CS(C)=O,,val
US20160002224A1,CCOC(=O)OC(C#Cc1nc(-c2ccc(C3(COC(C)=O)CC3)cc2)c(Cl)cc1NC(=O)C(F)(F)F)c1ccc(C)c(C(=O)OC)c1>>COC(=O)c1cc(Cc2cc3nc(-c4ccc(C5(COC(C)=O)CC5)cc4)c(Cl)cc3[nH]2)ccc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,CCOC(C)=O,CCN(CC)CC,O=CO,val
US20080015191A1,Clc1cncc(Cl)n1.Oc1ccc2ncccc2c1>>Clc1cncc(Oc2ccc3ncccc3c2)n1,,C1CCCCC1,CCOC(C)=O,,,val
US20020193361A1,C=CC[C@H](C)[C@@H](CC(=O)C(C)(C)C(OC(C)C)OC(C)C)OC(=O)OCC(Cl)(Cl)Cl>>C=CC[C@H](C)[C@@H](CC(=O)C(C)(C)C=O)OC(=O)OCC(Cl)(Cl)Cl,,C1CCOC1,O,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20120088750A1,CCOC(=O)C1(F)CCN(C(=O)OC(C)(C)C)CC1.Cl>>CCOC(=O)C1(F)CCNCC1.Cl,,C1COCCO1,,,,val
US20040152702A1,COC(=O)Nc1nc2c(OC)cccc2o1.ClI>>COC(=O)Nc1nc2c(OC)ccc(I)c2o1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20060281768A1,CC(C)(C)OC(=O)NC1CCN(c2ncnc3ccsc23)C1.Cl>>Cl.NC1CCN(c2ncnc3ccsc23)C1,,ClCCl,,CCOCC,,val
US04128562,CCCCOc1cc(O)c(C#N)s1.COP(=S)(Cl)OC>>CCCCOc1cc(OP(=S)(OC)OC)c(C#N)s1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20070082933A1,Cc1ccccc1N1C(=O)CS/C1=N\C(C)C.O=Cc1ccc2c(c1)OCCO2>>Cc1ccccc1N1C(=O)/C(=C/c2ccc3c(c2)OCCO3)S/C1=N\C(C)C,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20100204240A1,CC1(C)OC[C@@](C)(C(Cl)=NO)O1.CS(=O)(=O)Cl>>CC1(C)OC[C@@](C)(C(Cl)=NOS(C)(=O)=O)O1,,CCOCC,,CCN(CC)CC,,val
US20110172209A1,N#CBr.Nc1ccc(OCc2ccccc2)nc1Nc1ccc(Br)cc1>>Nc1nc2ccc(OCc3ccccc3)nc2n1-c1ccc(Br)cc1,,O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20090105214A1,COC(=O)c1cc(Oc2ccc3c(c2Cl)OCCN(C)C3=O)cc(O[C@H]2CCOC2)c1>>CN1CCOc2c(ccc(Oc3cc(O[C@H]4CCOC4)cc(C(=O)O)c3)c2Cl)C1=O,,C1CCOC1,O,[Na+].[OH-],,val
US20110046171A1,CCNC(=N)N1CC2(C=N1)CCCC2.COC(=O)c1cccc(S(=O)(=O)Cl)c1>>CCNC(=NS(=O)(=O)c1cccc(C(=O)OC)c1)N1CC2(C=N1)CCCC2,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20030119838A1,CNC.Cc1ccc(-c2cc(COS(C)(=O)=O)c(=O)n(CC(C)C)n2)cc1F>>Cc1ccc(-c2cc(CN(C)C)c(=O)n(CC(C)C)n2)cc1F,,O,,,,val
US04444775,Cl.O=C(O)CCCCCCc1cccc2cncn12>>Cl.O=C(O)CCCCCCC1CCCc2cncn21,[Pd],CCO,,[H][H],,val
US20100168418A1,COC(=O)c1cc(=O)n(CCNC2CCN(Cc3ccc4c(c3)OCCO4)CC2)c2cc(OC)ccc12.Cl>>COC(=O)c1cc(=O)n(CCNC2CCN(Cc3ccc4c(c3)OCCO4)CC2)c2cc(OC)ccc12.Cl,,CCOC(C)=O,,,,val
US05296591,CC(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NCC(=O)OCc2ccccc2)cc1)C(C)C)C(=O)C(F)(F)F>>CC(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NCC(=O)O)cc1)C(C)C)C(=O)C(F)(F)F,[Pd],CO,O,[H][H],,val
US20160039745A1,CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(C2=C[C@](C(=O)OCc3ccc(OC)cc3)(c3cccc(F)c3C)CC2)cc1>>CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(C2CC[C@@](C(=O)O)(c3cccc(F)c3C)C2)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US20150126741A1,CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)C=C[C@@]3(O)[C@H]1C5.O=CC1CC1>>Oc1ccc2c3c1O[C@H]1[C@H](O)CC[C@@]4(O)[C@@H](C2)N(CC2CC2)CC[C@]314,,CN(C)C=O,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040220185A1,C[C@@H](CC(CS(=O)(=O)N1CCN(c2ccc(C#C[Si](C)(C)C)cc2)CC1)NO)c1ccccc1.O=CO>>C#Cc1ccc(N2CCN(S(=O)(=O)CC(C[C@H](C)c3ccccc3)N(O)C=O)CC2)cc1,,ClCCl,,CC(=O)OC(C)=O,,val
US05858905,CC1c2cc(C(C)(C)C)cc(C(C)(C)C)c2OP(Cl)Oc2c1cc(C(C)(C)C)cc2C(C)(C)C.CC1c2cc(C(C)(C)C)cc(C(C)(C)C)c2O[PH](=O)Oc2c1cc(C(C)(C)C)cc2C(C)(C)C>>CC1c2cc(C(C)(C)C)cc(C(C)(C)C)c2OP(OP2Oc3c(cc(C(C)(C)C)cc3C(C)(C)C)C(C)c3cc(C(C)(C)C)cc(C(C)(C)C)c3O2)Oc2c1cc(C(C)(C)C)cc2C(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20130012491A1,CCc1c(CCN(C)CC(=O)OC)cccc1-c1cnc(-c2ccc(OC(C)C)c(Cl)c2)nc1>>CCc1c(CCN(C)CC(=O)O)cccc1-c1cnc(-c2ccc(OC(C)C)c(Cl)c2)nc1,,CC(C)O,O,[Na+].[OH-],,val
US20130261178A1,ClCC1CO1.Oc1ccc(OCCOC2CCCC2)cc1>>c1cc(OCC2CO2)ccc1OCCOC1CCCC1,,CN(C)C=O,,[H-].[Na+],,val
US05273980,Cc1ccc2cccnc2n1.O=C1CCC(=O)N1Cl>>ClCc1ccc2cccnc2n1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20050032786A1,CCOP(=O)(CCc1ccnc(C#N)c1)OCC.COC(=O)c1ccccc1S>>CCOP(=O)(CCc1ccnc(-c2nc(=O)c3ccccc3s2)c1)OCC,,Cc1ccccc1,,CCN(CC)CC,,val
US20110098324A1,CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(Cc2ccccc2Cl)c1=O.C[C@H](N)c1ccccc1>>C[C@H](NC(=O)c1c(O)c(C(=O)NCC(=O)O)c(=O)n(Cc2ccccc2Cl)c1O)c1ccccc1,,ClC(Cl)Cl,,,,val
US20100150831A1,COC(=O)CC(c1csc(N2CCC(O)CC2)n1)N1CCCN(c2c(OC)ccc3cccnc23)CC1>>COc1ccc2cccnc2c1N1CCCN(C(CC(=O)O)c2csc(N3CCC(O)CC3)n2)CC1,,C1CCOC1,,CO,[Na+].[OH-],val
US20090197856A1,CC(C)(C)OC(=O)NC1CCNc2c(Br)cccc21.COC(=O)c1ccc2c(C3CCCCC3)c(B3OC(C)(C)C(C)(C)O3)[nH]c2c1>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3cccc4c3NCCC4NC(=O)OC(C)(C)C)[nH]c2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCO,O=C([O-])[O-].[K+].[K+],,val
US20020198223A1,CCCOc1ccc(C(C)=O)cc1C(=O)O.CCCc1c(N)c(C(N)=O)nn1Cc1ccccn1>>CCCOc1ccc(C(C)=O)cc1C(=O)Nc1c(C(N)=O)nn(Cc2ccccn2)c1CCC,,CN(C)C=O,ClCCl,O=C(Cl)C(=O)Cl,,val
US20100317568A1,COC(=O)Cl.O=[N+]([O-])c1ccc(N2CCNCC2)c(F)c1>>COC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2F)CC1,,C1COCCO1,CCOC(C)=O,Cl,[Na+].[OH-],val
US20100160369A1,CI.N#Cc1ccc(O)cc1Cl>>COc1ccc(C#N)c(Cl)c1,,CN(C)C=O,,[H-].[Na+],,val
US20060264435A1,CCSc1ccc(-c2cc(Cl)ccc2OCC(=O)OC(C)(C)C)cc1>>CCSc1ccc(-c2cc(Cl)ccc2OCC(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04783467,CCOC(=O)CNCc1cc(F)ccc1[N+](=O)[O-].O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)CN(Cc1cc(F)ccc1[N+](=O)[O-])C(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20090312383A1,CCc1cc(CC)n(-c2cccc3nc(Cl)n(C)c23)n1.Cc1cc(Cl)cc(Cl)c1O>>CCc1cc(CC)n(-c2cccc3nc(Oc4c(C)cc(Cl)cc4Cl)n(C)c23)n1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040053908A1,Nc1cc(Oc2ccc3[nH]ccc3c2)ccn1.O=C=Nc1ccccc1>>Nc1cc(Oc2ccc3c(ccn3C(=O)Nc3ccccc3)c2)ccn1,,CN(C)C=O,,O,[H-].[Na+],val
US20100069348A1,CC(C)(C)c1cc(N)n(Cc2ccc(F)cc2)n1.O=C(Cl)c1cc(C(F)(F)F)ccc1F>>CC(C)(C)c1cc(NC(=O)c2cc(C(F)(F)F)ccc2F)n(Cc2ccc(F)cc2)n1,,C1CCOC1,,c1ccncc1,,val
US06432993B1,CN(C(=O)OC(C)(C)C)c1cc(Oc2cccc(O)c2)ccc1N.O=C(O)COc1ccc(CC2SC(=O)NC2=O)cc1>>CN(C(=O)OC(C)(C)C)c1cc(Oc2cccc(O)c2)ccc1NC(=O)COc1ccc(CC2SC(=O)NC2=O)cc1,,C1CCOC1,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20160207922A1,CS(=O)(=O)c1ccc(N2CC3(CCNCC3)OC2=O)nc1.Cc1c([C@@H]2CO2)ccc2c1COC2=O>>Cc1c([C@@H](O)CN2CCC3(CC2)CN(c2ccc(S(C)(=O)=O)cn2)C(=O)O3)ccc2c1COC2=O,,CCO,,,,val
US20060122168A1,CC[C@H]1Oc2ccc(F)cc2NC(=O)[C@H]1N(Cc1ccccc1)Cc1ccccc1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CC[C@H]1Oc2ccc(F)cc2N(CC(F)(F)F)C(=O)[C@H]1N(Cc1ccccc1)Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06204279B1,COC(=O)C1=COC([C@H](N)CCc2ccccc2)N1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1C(C(=O)O)=COC1[C@H](N)CCc1ccccc1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20040082571A1,O=C(CCl)N1CCN(c2ccc(Cl)cc2)CC1.c1ccc2[nH]cnc2c1>>O=C(Cn1cnc2ccccc21)N1CCN(c2ccc(Cl)cc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130143870A1,CC(=O)CO.CC(C)(C)OC(=O)N1CCN(C#N)CC1>>Cc1coc(N2CCN(C(=O)OC(C)(C)C)CC2)n1,,C1CCOC1,CCOCC,O,[Na+].[OH-],val
US20140371209A1,CCOC(=O)C1CCCN(Cc2ccc3cc(O[Si](C)(C)C(C)(C)C)ccc3n2)C1>>CCOC(=O)C1CCCN(Cc2ccc3cc(O)ccc3n2)C1,,CCO,,Cl,O=C([O-])O.[Na+],val
US04562207,CC(=O)O.CCCC[C@H]1CCC(C#N)C1.O=S(=O)(O)O>>CCCC[C@H]1CCC(C(=O)O)C1,,CCOC(C)=O,O,,,val
US20100197908A1,CC(=O)Cl.CC(C)(C)OC(=O)N1CCC(CN)CC1.ClCCl>>CC(=O)N(C)CC1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,O,c1ccncc1,val
US05990142,OCc1ccc(OCCCCc2ccccc2)cc1F>>O=Cc1ccc(OCCCCc2ccccc2)cc1F,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20100197651A1,CN(C)C=CC(=O)c1nn(-c2cccc(C(F)(F)F)c2)ccc1=O.NN>>O=c1ccn(-c2cccc(C(F)(F)F)c2)nc1-c1ccn[nH]1,,CO,,Cl,O,val
US20090143372A1,CCC(C)CN.CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(C=O)c4)cc23)CC1>>CCC(C)CNCc1cccc(-c2cc(C(N)=O)c3[nH]cc(C4CCN(S(=O)(=O)CC)CC4)c3c2)c1,CC(=O)O,CO,ClCCl,[BH4-].[Na+],,val
US20120022115A1,CC1(C)OC(=O)CC(=O)O1.O=C(Cl)C1CCCCC1>>CC1(C)OC(=O)C(C(=O)C2CCCCC2)C(=O)O1,,ClCCl,c1ccncc1,,,val
US05510326,C=C(C)CC(CO)C1CC=C(C)C1(C)C>>CC1=CCC(C2COC(C)(C)C2)C1(C)C,,CCCCCC,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20160152609A1,CC1(C)COCCN1.COc1cc2c(cc1CC(C)C)-n1c(Br)nc(C(=O)O)c1CC2>>COc1cc2c(cc1CC(C)C)-n1c(Br)nc(C(=O)N3CCOCC3(C)C)c1CC2,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100087431A1,CC(C)(C)[S@@](N)=O.ClCCCl.O=Cc1ccc(F)cc1Br>>C/C(=N\[S@@](=O)C(C)(C)C)c1ccc(F)cc1Br,,O,,,,val
US20140179670A1,Cc1c(-c2ccsc2)c(=O)n(C)c(=O)n1-c1cccc(C(F)(F)F)c1.O=C1CCC(=O)N1Br>>Cc1c(-c2ccsc2Br)c(=O)n(C)c(=O)n1-c1cccc(C(F)(F)F)c1,,CC(=O)O,,O=C([O-])O.[Na+],,val
US20100004292A1,CC(C)(C)[Si](C)(C)OCCN(C#N)c1ccc(NC(=O)c2cccnc2NC(=O)c2ccc(Cl)s2)cc1.CS(=O)(=O)O>>CS(=O)(=O)O.N=C1OCCN1c1ccc(NC(=O)c2cccnc2NC(=O)c2ccc(Cl)s2)cc1,,CCOCC,,,,val
US20050282819A1,CC1(C)C(=O)C(C)(C)c2cc(C(Cl)CN3CCN(c4noc5ccccc45)CC3)ccc21>>CC1(C)C(=O)C(C)(C)c2cc(CCN3CCN(c4noc5ccccc45)CC3)ccc21,,Cc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US20070281949A1,CCOCC(C#N)C#N.NNC1CCCCC1>>N#Cc1cnn(C2CCCCC2)c1N,,CCO,,Cl,C[O-].[Na+],val
US20100216746A1,C#C[Si](C)(C)C.C[Si](C)(C)CCOCn1cnc(Cl)c1C(=O)NCc1ccc(Cl)c(Oc2cc(Cl)cc(Br)c2)c1F>>C[Si](C)(C)C#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CNC(=O)c3c(Cl)ncn3COCC[Si](C)(C)C)c2F)c1,I[Cu]I,C1CCOC1,,,,val
US20100069431A1,CS(=O)(=O)Cl.Nc1cc(-c2nc3cccnc3[nH]2)cc(-c2ncccc2Cl)c1>>CS(=O)(=O)Nc1cc(-c2nc3cccnc3[nH]2)cc(-c2ncccc2Cl)c1,,ClCCl,,CCN(CC)CC,[Cl-].[NH4+],val
US05091384,CCI.O=C(O)c1cn(C2CC2)c2c(F)c(N3CC4=C(CNC4)C3)c(F)cc2c1=O>>CCN1CC2=C(C1)CN(c1c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c1F)C2,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110152273A1,CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.CCOC(=O)c1c(C)nc(S(C)(=O)=O)nc1-c1cnn(C)c1C>>CCOC(=O)c1c(C)nc(N[C@@H]2CCCC[C@@H]2NC(=O)OC(C)(C)C)nc1-c1cnn(C)c1C,,CC(=O)N(C)C,,CCN(CC)CC,,val
US20130253191A1,CC(CC#N)n1cc(-c2ncnc3c2ccn3COCC[Si](C)(C)C)cn1>>C[C@@H](CC#N)n1cc(-c2ncnc3c2ccn3COCC[Si](C)(C)C)cn1,,CCO,,,,val
US06235787B1,BrCc1ccccc1.C=CCOC(=O)[C@H](CC(C)C)[C@H](O)C(=O)OC>>C=CCOC(=O)[C@H](CC(C)C)[C@H](OCc1ccccc1)C(=O)OC,O=[Ag-],CCOCC,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050159469A1,COC(=O)N[C@H](C(=O)NN(Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(C)(C)C>>COC(=O)N[C@H](C(=O)NN(Cc1ccccc1)C[C@H](O)[C@@H](N)Cc1ccccc1)C(C)(C)C,,C1CCOC1,,Cl,,val
US20020161237A1,CC(C)c1ncsc1C=O.COC(=O)C(NC(=O)c1ccc(C(=O)NCc2cccc(O)c2)cc1Cl)P(=O)(OC)OC>>COC(=O)/C(=C/c1scnc1C(C)C)NC(=O)c1ccc(C(=O)NCc2cccc(O)c2)cc1Cl,,C1CCOC1,,CN(C)C(=N)N(C)C,,val
US06537948B1,COC(=O)COc1nc(OC)ccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1[N+](=O)[O-]>>COC(=O)COc1nc(OC)ccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1N,[Fe],CC(=O)O,,O,,val
US20130096118A1,O=C(c1ccc2c(C(C[N+](=O)[O-])c3ccccc3F)c[nH]c2c1)N1CCOCC1>>NCC(c1ccccc1F)c1c[nH]c2cc(C(=O)N3CCOCC3)ccc12,[Ni],CO,,,,val
US05962492,CCCCCC.CCOC(C)=O.CCOC(C)=O.CO.Cc1ccncc1.[Li]CCCC.c1ccncc1>>COc1ccc(C(O)Cc2ccncc2)cc1OC1CCCC1,,c1ccncc1,,,,val
US20090203676A1,CC(C)(C)OC(=O)N1CCC(CCOS(C)(=O)=O)CC1.O=C1CCNCC1>>CC(C)(C)OC(=O)N1CCC(CCN2CCC(=O)CC2)CC1,,CC#N,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US07709468B2,COc1nccn2c(-c3ccnc(NC4CC4)n3)c(-c3ccc(F)cc3)nc12>>O=c1[nH]ccn2c(-c3ccnc(NC4CC4)n3)c(-c3ccc(F)cc3)nc12,,CCOCC,,Br,CC(=O)O,val
US20080171789A1,CC(=O)O[C@H](C)[C@@H](C)OC(=O)[C@H](Cc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1)NC(=O)OC(C)(C)C>>CC(=O)O[C@H](C)[C@@H](C)OC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)OC(C)(C)C,[Pd],CO,,[H][H],,val
US20160168131A1,CC(C)(C)OC(=O)N1C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H]1c1nc2ccc(F)c(Br)c2c(=O)n1-c1ccccc1.CCCC[Sn](CCCC)(CCCC)c1cnn(C)c1>>Cn1cc(-c2c(F)ccc3nc([C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CN4C(=O)OC(C)(C)C)n(-c4ccccc4)c(=O)c23)cn1,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,CCOC(C)=O,CN(C)C=O,,,val
US20020052397A1,C[O-].Cn1ccc2ccccc21.O=C(Cl)C(=O)Cl>>COC(=O)C(=O)c1cn(C)c2ccccc12,,CCOCC,,O,,val
US20070213341A1,C=C(N=Cc1ccccc1C)O[Si](C)(C)C.CC(C)(C)OC(=O)N1C(=O)/C(=C\c2cccc(Cl)c2)c2ccc(Cl)cc21>>Cc1ccccc1C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)N(C(=O)OC(C)(C)C)c1cc(Cl)ccc12,,Cc1ccccc1,,,,val
US05616596,C(=Cc1ccco1)c1cccnc1.II>>Ic1ccc(C=Cc2cccnc2)o1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20110257198A1,Cc1cccn2c(C)c(C[C@@H]3CCCCN3C(=O)OC(C)(C)C)nc12>>Cc1cccn2c(C)c(C[C@@H]3CCCCN3)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050203107A1,CCCS(=O)(=O)c1nc(Cl)c2ncn(-c3ccc(Cl)cc3)c2n1.CCN(C(C)C)C(C)C.NC(=O)[C@@H]1CCCN1>>N#Cc1nc(N2CCC[C@H]2C(N)=O)c2ncn(-c3ccc(Cl)cc3)c2n1,,C1CCOC1,,,,val
US04810806,COC(=O)C(F)(F)C(F)(F)C(=O)OC.OCCCl>>COC(=O)C(F)(F)C(F)(F)C1(OC)OCCO1,,CCOCC,O,CS(C)=O,[H-].[Na+],val
US20150080362A1,CCOC(=O)C(C(=O)OCC)C(=O)OCC.CN(C)c1ccc(C(CCc2ccccc2)=NC(C)(C)C)cc1>>COC(=O)c1c(O)c(Cc2ccccc2)c(-c2ccc(N(C)C)cc2)[nH]c1=O,,COCCOCCOC,,,,val
US20090312338A1,COc1ccc2c(c1)c(-c1cc3nc(CN=[N+]=[N-])cnc3n1COCC[Si](C)(C)C)cn2C.O>>COc1ccc2c(c1)c(-c1cc3nc(CN)cnc3n1COCC[Si](C)(C)C)cn2C.[NH4+].[OH-],,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US03935223,CCOC(=O)CC(=N)N.N#Cc1ccccc1C=O.O=C1CCCC(=O)C1>>CCOC(=O)C1=C(N)NC2=C(C(=O)CCC2)C1c1ccccc1C#N,,CCO,,,,val
US20120101127A1,CC1(C)CC(c2cccc(N)c2)Nc2ccc(C#N)cc21.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)Nc2cccc(C3CC(C)(C)c4cc(C#N)ccc4N3)c2)cc1,,ClCCl,,c1ccncc1,,val
US20160122302A1,Cc1cc(CCc2cccc(C(Cc3cc(C)cc(-n4c(C)ccc4C)n3)C[N+](=O)[O-])c2)nc(-n2c(C)ccc2C)c1>>Cc1cc(CCc2cccc(C(CN)Cc3cc(C)cc(-n4c(C)ccc4C)n3)c2)nc(-n2c(C)ccc2C)c1,[Ni],CCO,CO,,,val
US20120115846A1,COc1ccc(Cn2c(=O)c3cc(C#N)ccc3n(C3CCOCC3)c2=O)cc1OC>>COc1ccc(Cn2c(=O)c3cc(CN)ccc3n(C3CCOCC3)c2=O)cc1OC,,C1CCOC1,ClCCl,Cl,[Na+].[OH-],val
US20060135534A1,CN(CCN)c1ccc([N+](=O)[O-])cn1.O=[N+]([O-])c1ncc(Br)nc1-c1ccc(Cl)cc1Cl>>CN(CCNc1ccc([N+](=O)[O-])cn1)c1cnc([N+](=O)[O-])c(-c2ccc(Cl)cc2Cl)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US06291458B1,Cc1ccc(N2CCN(C)CC2)c2c1CC[C@@H](NC(=O)c1ccc(N3CCOCC3)cc1)C2.O=C(O)CO>>Cc1ccc(N2CCN(C)CC2)c2c1CC[C@@H](NC(=O)c1ccc(N3CCOCC3)cc1)C2.O=C(O)CO,,CCO,,,,val
US20070060754A1,CCCCc1nc2c(N)nc3ccc(OCCC4CCNCC4)cc3c2n1C.CS(=O)(=O)OS(C)(=O)=O>>CCCCc1nc2c(N)nc3ccc(OCCC4CCN(S(C)(=O)=O)CC4)cc3c2n1C,,ClCCl,,CCN(CC)CC,O,val
US20040072887A1,CI.Cc1cscc1C(=O)O>>Cc1csc(C)c1C(=O)O,,C1CCOC1,,[Li]CCCC,,val
US20140148412A1,C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CBr.Nc1ccccn1>>C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@@]43C)[C@@H]1CC[C@@H]2c1cn2ccccc2n1,,CCO,,,,val
US04061730,CCOC(C)=O.CN(C)c1ccc(C=C2C(=O)C3(C)CCC2C3(C)C)cc1.COS(=O)(=O)[O-]>>CC12CCC(C(=Cc3ccc([N+](C)(C)C)cc3)C1=O)C2(C)C.COS(=O)(=O)[O-],,CCOC(C)=O,,,,val
US20120040954A1,CI.COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCCNCC4)cc3)nc2c1>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCCN(C)CC4)cc3)nc2c1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US04144228,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)O.CS(=O)CC[C@H](N)C(=O)O>>CS(=O)CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)O,,CN(C)C=O,O,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20050222210A1,CN(CCO)C(=O)OC(C)(C)C.O=C(Cl)c1ccc(F)c(F)c1>>CNCCOC(=O)c1ccc(F)c(F)c1.Cl,,CCOC(C)=O,,c1ccncc1,,val
US20090054471A1,N#CCC#N.N[n+]1ccccc1>>N#Cc1c(N)nn2ccccc12,,CCO,,[I-].[K+],,val
US20130196993A1,Cc1cc(NC(C)CNC(=O)OC(C)(C)C)cc(C)n1.Cl>>Cc1cc(NC(C)CN)cc(C)n1.Cl,,C1COCCO1,,,,val
US20050043248A1,CCCC1(F)CCN(C(=O)OC(C)(C)C)C(C(=O)OC)C1>>CCCCC1(F)CN[C@H](C(=O)O)C1,,O,,C1CCOC1,[Li+].[OH-],val
US03935223,CC=O.CCOC(=O)CC(=N)N.O=C1CCCC(=O)C1>>CCOC(=O)C1=C(N)NC2=C(C(=O)CCC2)C1C,,CCO,,,,val
US20050004134A1,CC(C)n1nc(C(Cl)C(=O)c2ccc(F)cc2)ccc1=O.NC(N)=S>>CC(C)n1nc(-c2sc(N)nc2-c2ccc(F)cc2)ccc1=O,,C1COCCO1,,O,O=C([O-])O.[Na+],val
US06316389B1,CCOC(=O)Cl.COC(=O)C=NOCC1=C(CN2CCOCC2)CC(C)=C(C)C1>>COC(=O)C=NOCC1=C(CCl)CC(C)=C(C)C1,,C1CCOC1,,,,val
US06878700B1,COc1ccccc1Sc1ccc(C=O)c(Cl)c1Cl.O=C(O)CC(=O)O>>COc1ccccc1Sc1ccc(C=CC(=O)O)c(Cl)c1Cl,,c1ccncc1,,C1CCNCC1,Cl,val
US05242619,COC=C(C=O)c1ccc(C#N)cc1.N=C(N)c1ccc(C(N)=O)cc1>>N#Cc1ccc(-c2cnc(-c3ccc(C(N)=O)cc3)nc2)cc1,,CO,,Cl,[Na],val
US20140328805A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nc(N2CC3CC2C3)n1>>Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CN4)nc(N3CC4CC3C4)n2)cc1C(F)(F)F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060094767A1,CC(O)(CCC(=O)OC(C)(C)C)Cn1cc([N+](=O)[O-])nc1Cl>>CC(C)(C)OC(=O)CCC1(C)Cn2cc([N+](=O)[O-])nc2O1,,C1COCCO1,,[H-].[Na+],,val
US20120022080A1,COC(=O)c1cc(Cl)ccc1NC(=O)Cc1cccc(-c2ccoc2)c1>>O=C(Cc1cccc(-c2ccoc2)c1)Nc1ccc(Cl)cc1C(=O)O,,C1CCOC1,,Cl,[Na+].[OH-],val
US20030069297A1,CCN(CC)CCNC(=O)c1c[nH]c(C=O)c1C.COc1cccc(-c2cccc3c2CC(=O)N3)c1>>CCN(CC)CCNC(=O)c1c[nH]c(C=C2C(=O)Nc3cccc(-c4cccc(OC)c4)c32)c1C,C1CCNCC1,CCO,,,,val
US20060154929A1,CC(=O)C(C(C)=O)C(C(C)=O)C(C)=O.CCOc1ccc(N)c(CO)c1.NN>>CCOc1ccc(-n2c(C)c3c(C)nnc(C)c3c2C)c(CO)c1,,CCO,,CC(=O)O,,val
US20090036492A1,COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.Cc1ccc2ccc(Cl)cc2c1C=O>>COc1cc(O)c2c(c1C(=O)NCc1c(C)ccc3ccc(Cl)cc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,,CC#N,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20150152108A1,FC(F)(F)c1cccc(-c2ccc3c(n2)N[C@H]2CCN3C2)c1.O=C(Nc1ccncc1F)Oc1ccccc1>>O=C(Nc1ccncc1F)N1c2nc(-c3cccc(C(F)(F)F)c3)ccc2N2CC[C@H]1C2,CN(C)c1ccncc1,CC#N,,,,val
US03998829,C=CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C.OC(=S)c1cccnc1>>C[C@]12CC[C@@H](O)C[C@@H]1CC[C@@H]1[C@@H]2C(=O)C[C@]2(C)[C@@H](C(=O)CCSCc3cccnc3)CC[C@@H]12,,CC(C)=O,,,,val
US20040044211A1,NC1CC1.O=Cc1ccc(Cl)cc1Cl>>Clc1ccc(CNC2CC2)c(Cl)c1,,CO,,[BH4-].[Na+],,val
US06350749B1,Cl.N=C(N)NN.O=C1CC(c2ccccc2)Cc2[nH]c(=O)ccc21>>Cl.N=C(N)NN=C1CC(c2ccccc2)Cc2[nH]c(=O)ccc21,,CCO,,Cl,O,val
US20030105098A1,ON=C1CCN(Cc2ccc(Cl)cc2)CC1>>NC1CCN(Cc2ccc(Cl)cc2)CC1,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20040132727A1,COc1ccccc1NC(=O)COc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1>>COc1ccccc1NCCOc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20090176786A1,CN(C(=O)Cl)c1ccc(SC(F)(F)F)cc1F.NCc1ccco1>>CN(C(=O)NCc1ccco1)c1ccc(SC(F)(F)F)cc1F,,COC(C)(C)C,,CCN(CC)CC,,val
US05374637,C=C(C)CCl.COC(=O)c1ccc(NC(C)=O)cc1O>>C=C(C)COc1cc(NC(C)=O)ccc1C(=O)OC,,CN(C)C=O,,[H-].[Na+],,val
US20130178540A1,CCCCCCCCCCOC(=O)C(O)CCSC.O=C(OO)c1cccc(Cl)c1>>CCCCCCCCCCOC(=O)C(O)CCS(C)=O,,ClCCl,,,,val
US20150183749A1,CI.Cc1ccc(S(=O)(=O)n2cc(F)c(N)nc2=O)cc1>>Cc1ccc(S(=O)(=O)n2cc(F)c(=N)n(C)c2=O)cc1,,CC#N,CN(C)C=O,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20090181928A1,CC(=O)OCCCCS(=O)(=O)Cc1ccccc1>>O=S(=O)(CCCCO)Cc1ccccc1,,CO,,[Na+].[OH-],,val
US20070265225A1,O=C(CBr)OCc1ccccc1.O=C1N[C@H](c2ccccc2)CCNC12CCCC2>>O=C(CN1C(=O)C2(CCCC2)NCC[C@H]1c1ccccc1)OCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20070244120A1,CC(C)(C)c1cc(N)on1.O=C=Nc1ccc(Oc2ccccc2)cc1>>CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)on1,,ClCCl,,O,,val
US20140114068A1,CC(C)c1ccc2c(c1)OC1(O)c3cccc([N+](=O)[O-])c3C(=O)C21NC(=O)c1nccn1C>>CC(C)c1ccc2c(c1)OC1(O)c3cccc(N)c3C(=O)C21NC(=O)c1nccn1C,[Fe],CCO,,Cl,O,val
US05565586,C=CC(C)(CCl)OC(C)=O.O=[N+]([O-])c1ccc(O)cc1>>C=CC(C)(O)COc1ccc([N+](=O)[O-])cc1,,CN(C)C=O,O,[H-].[Na+],O=C([O-])[O-].[K+].[K+],val
US20130079339A1,CC(C)Oc1cc(C(F)(F)F)ccc1CN.Nc1cccc2c1OCC(=O)N2.O=C(n1ccnc1)n1ccnc1>>Cc1ccc(CNC(=O)Nc2cccc3c2OCC(=O)N3)c(OC(C)C)c1,,C1CCOC1,CN(C)C=O,,,val
US05145860,COc1ccc(-c2nc(CNC(C)=O)sc2-c2ccc(OC)cc2)cc1.Cl>>COc1ccc(-c2nc(CN)sc2-c2ccc(OC)cc2)cc1.Cl,,O,,[Na+].[OH-],,val
US20120145973A1,COC(=O)c1cc(OC(C)=O)c2ccc(OC)cc2c1-c1ccc(Br)cc1.OB(O)c1ccccc1>>COC(=O)c1cc(OC(C)=O)c2ccc(OC)cc2c1-c1ccc(-c2ccccc2)cc1,,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US20090215779A1,COC(=O)C[C@@H]1CC[C@@H](c2ccc(NC(=O)c3nnc(NC(=O)c4ccc(Cl)cc4)o3)cc2)CC1>>O=C(O)C[C@@H]1CC[C@@H](c2ccc(NC(=O)c3nnc(NC(=O)c4ccc(Cl)cc4)o3)cc2)CC1,,CO,O,Cl,[Li+].[OH-],val
US20060069132A1,CCOS(=O)(=O)OCC.O=C(O)c1ccc(F)c([N+](=O)[O-])c1>>CCOC(=O)c1ccc(F)c([N+](=O)[O-])c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06657062B1,OC1(c2ccc(F)cc2)CCN(Cc2ccccc2)CC1>>Fc1ccc(C2=CCN(Cc3ccccc3)CC2)cc1,,Clc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20050171154A1,N#CN=C1NCCN1c1ccc([N+](=O)[O-])cc1>>N#CN=C1NCCN1c1ccc(N)cc1,[Pd],CO,,[H][H],,val
US04738959,COc1ccsc1.CSSC>>COc1ccsc1SC,,CCOCC,O,CCCCCC,[Li]CCCC,val
US20160002177A1,COCc1cc(C(=O)OC)ccc1-c1cc(OCOCC[Si](C)(C)C)c2ncn(COCC[Si](C)(C)C)c(=O)c2c1>>COCc1cc(C(=O)O)ccc1-c1cc(OCOCC[Si](C)(C)C)c2ncn(COCC[Si](C)(C)C)c(=O)c2c1,,C1CCOC1,CO,[Li+].[OH-],,val
US05144048,CCOC(=O)[C@H](O)[C@@H](O)C(=O)OCC.CCOc1cc(C=O)ccc1O>>CCOC(=O)[C@@H]1OC(c2ccc(O)c(OCC)c2)O[C@H]1C(=O)OCC,Cc1ccc(S(=O)(=O)O)cc1,CO,,Cc1ccccc1,O,val
US20050075281A1,CC1(C=O)CCCCC1.COC(=O)C(NC(=O)OCc1ccccc1)P(=O)(OC)OC>>COC(=O)/C(=C/C1(C)CCCCC1)NC(=O)OCc1ccccc1,,C1CCOC1,,CN(C)C(=N)N(C)C,,val
US20030158235A1,OCc1ccc(OCc2cccc(F)c2)cn1>>O=Cc1ccc(OCc2cccc(F)c2)cn1,O=[Mn]=O,ClC(Cl)Cl,,,,val
US20120252808A1,CCOC(=O)c1cc(O)c2ccccc2n1.O=P(Br)(Br)Br>>CCOC(=O)c1cc(Br)c2ccccc2n1,,CC#N,Cc1ccccc1,,,val
US20140206663A1,CC1C(=O)NN=C2COc3cc(Oc4ccccc4)c(NC4CNC4)cc3N21.O=C(O)C(F)(F)F>>CC1C(=O)NN=C2COc3cc(Oc4ccccc4)c(NC4CNC4)cc3N21.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20150057273A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)cc1.N[C@H]1CC[C@@H](Oc2ccc3nnc(-c4ccnc(N5CCCC5)c4)n3c2)c2ccccc21.O=CO>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(-c5ccnc(N6CCCC6)c5)n4c3)c3ccccc32)cc1.O=CO,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20130336965A1,C=CC(=O)OC.C[C@H]1CC(c2ccncc2[N+](=O)[O-])=C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O>>COC(=O)CCO[C@H]1[C@H](NC(=O)OC(C)(C)C)C=C(c2ccncc2[N+](=O)[O-])C[C@@H]1C,,CC(C)(C)O,O,O=C([O-])[O-].[Cs+].[Cs+],O=C([O-])O.[Na+],val
US20100311798A1,CC(=O)[C@H](CCC1CCCCC1)NC(=O)OC(C)(C)C>>CC(O)[C@H](CCC1CCCCC1)NC(=O)OC(C)(C)C,,CCO,ClCCl,[BH4-].[Na+],,val
US20090325956A1,Cc1cc(C)nc(N)c1.O=C(O)c1cc(COc2cc(Cl)ccc2Cl)ccn1>>Cc1cc(C)nc(NC(=O)c2cc(COc3cc(Cl)ccc3Cl)ccn2)c1,,CN(C)C=O,,CCN(CC)CC,CCOC(C)=O,val
US20060052599A1,CC(Cl)OC(=O)Cl.CCOC(=O)/C=C/c1csc(NC2CCN(Cc3ccccc3)CC2)n1.ClCCl>>CCOC(=O)/C=C/c1csc(NC2CCNCC2)n1.Cl.Cl,,ClCCl,,,,val
US20120083475A1,BrC(Br)(Br)Br.CC[Si](CC)(CC)c1[nH]c2ccc(C#N)cc2c1CCO>>CC[Si](CC)(CC)c1[nH]c2ccc(C#N)cc2c1CCBr,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120053166A1,C1CCC2(C1)CNCCO2.O=S(=O)(c1ccccc1)n1ncc2c(-c3nnc(CCl)o3)cc(Br)cc21>>O=S(=O)(c1ccccc1)n1ncc2c(-c3nnc(CN4CCOC5(CCCC5)C4)o3)cc(Br)cc21,,CC#N,ClCCl,CCN(C(C)C)C(C)C,[I-].[Na+],val
US20150336925A1,CCOC(=O)c1[nH]c2c(Br)cccc2c1CCCOc1cc(C)c(Cl)c(C)c1.OB(O)c1ccco1>>CCOC(=O)c1[nH]c2c(-c3ccco3)cccc2c1CCCOc1cc(C)c(Cl)c(C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,COCCOC,[Cs+].[F-],,val
US20060111375A1,C1COCCN1.COc1cc2c(Oc3cc4cccnc4nc3C)ccnc2cc1O.ClCCBr>>COc1cc2c(Oc3cc4cccnc4nc3C)ccnc2cc1OCCN1CCOCC1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100022560A1,CCCCCC(=O)CC(C)=O.Cc1cc(N)[nH]n1>>CCCCc1cc(C)nc2cc(C)nn12,C1CCNCC1,CCO,,,,val
US04698337,O=CNc1nc(C(=NOCCBr)C(=O)NC2C(=O)N3C(C(=O)O)=C(CSc4nncs4)CS[C@H]23)cs1>>Nc1nc(C(=NOCCBr)C(=O)NC2C(=O)N3C(C(=O)O)=C(CSc4nncs4)CS[C@H]23)cs1,,CO,,C1CCOC1,Cl,val
US20110237573A1,Cc1cc(CC(=O)OC(C)(C)C)ccc1-c1ccnnc1>>Cc1cc(CC(=O)O)ccc1-c1ccnnc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140350010A1,CCOC(=O)C(=O)CC(=O)C(C)C.Cc1cc(Cl)ccc1C=O.N#Cc1cc(N)cc(Cl)c1>>Cc1cc(Cl)ccc1C1C(C(=O)C(C)C)=C(O)C(=O)N1c1cc(Cl)cc(C#N)c1,,CC(=O)O,,,,val
US04251454,CN(C)c1cc(C(O)CS(C)(=O)=O)cc(N(C)C)c1N(C)C.N#CCCNc1ccccc1>>CN(C)c1cc(CC(C#N)=CNc2ccccc2)cc(N(C)C)c1N(C)C,,CS(C)=O,,C[O-].[Na+],,val
US20020028832A1,CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)c3ccc(OCc4ccccc4)c(NS(C)(=O)=O)c3)cc2)CC1>>CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)cc2)CC1,[Pd],CCO,,[H][H],,val
US20110105509A1,CCO.COC(=O)CCC(=O)C(=O)OC.NNCc1ccc(F)cc1F>>CCOC(=O)C1=NN(Cc2ccc(F)cc2F)C(=O)CC1,Cl,,,,,val
US20150203492A1,CC1CCCC(C(=O)Cl)C1.CNOC>>CON(C)C(=O)C1CCCC(C)C1,,ClC(Cl)Cl,,Cl,c1ccncc1,val
US04900477,CC(C)CCC[C@@H](C)[C@H]1CC=C2C3=CC[C@H]4C[C@@H](OC(=O)c5ccccc5)CC[C@]4(C)[C@H]3CC[C@@]21C.O=C(OO)c1cccc(Cl)c1>>CC(C)CCC[C@@H](C)[C@H]1C[C@@H]2O[C@@]23C2=CC[C@H]4C[C@@H](OC(=O)c5ccccc5)CC[C@]4(C)[C@H]2CC[C@]13C,,COC(C)(C)C,,O,O=C([O-])O.[Na+],val
US05723497,CCCCC(CC)CBr.OCCCCCCCCCCO>>CCCCC(CC)COCCCCCCCCCCO,,Cc1ccccc1C,,[K+].[OH-],,val
US20100234344A1,CNC(C)C.O=C(CBr)Oc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>CC(C)N(C)C(=O)CBr,,ClCCl,,,,val
US20090269301A1,CCCCCCC(=O)C(=O)OCC.COc1ccc(C=O)cc1.NCCCn1ccnc1>>CCCCCC1=C(O)C(=O)N(CCCn2ccnc2)C1c1ccc(OC)cc1,,CCO,,,,val
US20020052512A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cccc2nc[nH]c12>>Cc1cccc2c1ncn2C(=O)OC(C)(C)C,,CC#N,,,,val
US04999436,CC(=O)OC1C=C(c2cccs2)SC1c1ccccc1>>CC(=O)Oc1cc(-c2cccs2)sc1-c1ccccc1,,c1ccccc1,,,,val
US20110130380A1,CCC1(CNc2nc(F)ccc2F)CCOCC1.CO>>CCC1(CNc2nc(OC)ccc2F)CCOCC1,,CO,,C[O-].[Na+],,val
US20150018546A1,CC(=O)Cl.CCOC(=O)c1c(NCc2ccc(N)cc2)c2c(C)ncnc2n(OCc2ccccc2)c1=O>>CCOC(=O)c1c(NCc2ccc(NC(C)=O)cc2)c2c(C)ncnc2n(OCc2ccccc2)c1=O,,CCN(CC)CC,ClCCl,,,val
US04948794,CNc1cc(OC)c(OC)cc1[N+](=O)[O-]>>CNc1cc(OC)c(OC)cc1N,[Pd],CCO,,Cl,,val
US04647694,COc1cc(C=C2NC(=O)NC2=O)cc(OC)c1OC>>COc1cc(CC2NC(=O)NC2=O)cc(OC)c1OC,[Ni],[Na+],[OH-],,,val
US04870074,COc1cc(N)c(Cl)cc1C(=O)O.NCCCC1CN(Cc2ccccc2)CCO1>>COc1cc(N)c(Cl)cc1C(=O)NCCCC1CN(Cc2ccccc2)CCO1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US04767768,C/C=C(/C=O)CC.CCOP(=O)(CC#N)OCC>>C/C=C(/C=C/C#N)CC,,O,c1ccccc1,[H-].[Na+],,val
US04689426,CCCCC1C=CC(=O)C1=CCCCCCC(=O)OC.OO>>CCCCC1C(=CCCCCCC(=O)OC)C(=O)C2=C1O2,,CO,,[H-].[Na+],[Cl-].[NH4+],val
US20060211716A1,CI.Nc1cccc(C(F)(F)F)c1.S=C=S>>CSC(=S)Nc1cccc(C(F)(F)F)c1,,CS(C)=O,O,[Na+].[OH-],,val
US06437196B1,CCCCCCCCOCC1CO1.O>>CCCCCCCCOCC(O)CO,,O,,CC(=O)O,[Na+].[OH-],val
US05597922,CCOC(=S)C(N)=O.Nc1cc(C(F)(F)F)cc(Cl)c1N>>Nc1nc2c(Cl)cc(C(F)(F)F)cc2[nH]c1=O,,CCCCO,,,,val
US20120101105A1,ON=C1CCCc2cc(OCC(F)(F)F)cnc21>>NC1CCCc2cc(OCC(F)(F)F)cnc21,[Pd],CO,,,,val
US20100152450A1,CN.COC(=O)CCc1cc(-c2cncc(OC[C@@H]3CCN3C(=O)OC(C)(C)C)c2)on1>>CNC(=O)CCc1cc(-c2cncc(OC[C@@H]3CCN3C(=O)OC(C)(C)C)c2)on1,,C1COCCO1,,O,,val
US20070249670A1,Cc1cc(C)c(NC(=O)Nc2cc(-c3ccc(CN4CCCC4)cc3)ccc2C(=O)N[C@H](C(=O)OC(C)(C)C)C2CCCCC2)c(C)c1>>Cc1cc(C)c(NC(=O)Nc2cc(-c3ccc(CN4CCCC4)cc3)ccc2C(=O)N[C@H](C(=O)O)C2CCCCC2)c(C)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140296205A1,CCN(C(=O)OC(C)(C)C)C1=N[C@@H]2[C@H](F)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](CO)O[C@@H]2S1.ClCCl>>CCN(C(=O)OC(C)(C)C)C1=N[C@@H]2[C@H](F)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]([C@H](C)O)O[C@@H]2S1,,C1CCOC1,,,,val
US20110105462A1,COc1ccc2c(c1)OC(CO)CO2.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1ccc2c(c1)OC(COS(=O)(=O)c1ccc(C)cc1)CO2,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US20100094000A1,CC1(C)OB(c2ccc3c(c2)NC(=O)CO3)OC1(C)C.Cc1nn(CC2CCC(=O)CC2)c(-c2ccc(F)cc2)c1Br>>Cc1nn(CC2CCC(=O)CC2)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2,,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04939130,CCOP(=O)(OCC)C(Cn1cccn1)P(=O)(OCC)OCC.CCOP(=O)(OCC)C(Cn1ccnc1)P(=O)(OCC)OCC>>O=P(O)(O)C(Cn1cccn1)P(=O)(O)O.O=P(O)(O)C(Cn1ccnc1)P(=O)(O)O,,CO,,C[Si](C)(C)Br,,val
US20090247519A1,CC[C@H](CNc1nc(-c2cc(O)ccc2OC)ncc1F)NC(=O)OC(C)(C)C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC[C@H](CNc1nc(-c2cc(OS(=O)(=O)C(F)(F)F)ccc2OC)ncc1F)NC(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,O,val
US20070043084A1,COc1ccc(NC(=N)c2ccc(OC)cc2)cc1.N#CC=CCl>>COc1ccc(C2=NC(C#N)CN2c2ccc(OC)cc2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US04914096,CC#N.COC(=O)c1ccc(CCc2cc(OC)c(OC)c(OC)c2)cc1>>COc1cc(CCc2ccc(C(=O)CC#N)cc2)cc(OC)c1OC,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20070099990A1,COc1ccc(CC(=O)O)cc1.Cc1ccc([C@@H]2c3c(C)c(N)c(C)c(C)c3OC2(C)C)cc1>>COc1ccc(CC(=O)Nc2c(C)c(C)c3c(c2C)[C@@H](c2ccc(C)cc2)C(C)(C)O3)cc1,,CCCCCC,CCOC(C)=O,,,val
US20020120139A1,COC(=O)C=Cc1cncnc1>>COC(=O)CCc1cncnc1,[Pd],CC(=O)O,,O=C[O-].[NH4+],,val
US20070112023A1,CC(C)N.O=[N+]([O-])c1ccc(-c2ccc(S(=O)(=O)Cl)cc2)cc1>>CC(C)NS(=O)(=O)c1ccc(-c2ccc([N+](=O)[O-])cc2)cc1,,CN(C)C=O,,O,,val
US05438052,Cn1c(CON2C(=O)c3ccccc3C2=O)ncc(OCc2ccccc2)c1=O>>Cn1c(CON2C(=O)c3ccccc3C2=O)ncc(O)c1=O,,ClCCl,,BrB(Br)Br,,val
US20100239526A1,COc1ccc(Cn2ncc3c4c(cnc32)CCc2nc(C)sc2-4)cc1>>Cc1nc2c(s1)-c1c(cnc3[nH]ncc13)CC2,,O=C(O)C(F)(F)F,,O,O=C([O-])[O-].[K+].[K+],val
US20130338066A1,CC(C)(O)C(c1ccc(N2CCOCC2)cc1)S(N)(=O)=O.COC(OC)(OC)OC>>COC1=NS(=O)(=O)C(c2ccc(N3CCOCC3)cc2)C(C)(C)O1,,C1COCCO1,,CC(=O)O,,val
US04147672,C=CCC#CC1=CC(C)(C)CCC1>>C=CCC#CC1=CCCC(C)(C)C1,,O,,CO,,val
US20130029969A1,C1CCNC1.NC(=O)c1sc(Br)cc1N.O=C(Cl)CCCl>>O=c1[nH]c(CCN2CCCC2)nc2cc(Br)sc12,,C1CCOC1,,CCN(CC)CC,,val
US20140243336A1,CC(C)(C)OC(=O)N[C@H]1CCS(=O)(=O)C[C@H]1N.N#Cc1ncc(F)cc1Br>>CC(C)(C)OC(=O)N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C#N)c(Br)c1,,CN1CCCC1=O,O,CCN(C(C)C)C(C)C,,val
US20090247507A1,CC(C)(C)OC(=O)NCc1ccc(-c2nc3c(N4CCN(CC(=O)Nc5nccs5)CC4)c(Br)cnc3[nH]2)cc1>>NCc1ccc(-c2nc3c(N4CCN(CC(=O)Nc5nccs5)CC4)c(Br)cnc3[nH]2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060111347A1,CC(C)S(=O)(=O)c1ccc2ccccc2c1.COC(=O)CCI>>COC(=O)CCC(C)(C)S(=O)(=O)c1ccc2ccccc2c1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20120283222A1,Cl.N=C(N)c1ccc(O)cc1.O=[N+]([O-])O>>Cl.N=C(N)c1ccc(O)c([N+](=O)[O-])c1,,O=S(=O)(O)O,,O=C([O-])O.[Na+],,val
US20140031364A1,Clc1ccc(N2CCNCC2)cc1Cl.Nc1onc(-c2ccccc2Cl)c1C(=O)O>>Nc1onc(-c2ccccc2Cl)c1C(=O)N1CCN(c2ccc(Cl)c(Cl)c2)CC1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20140045687A1,CN1C(=O)C(Cl)=C(Cl)C1=O.Cc1ccc(S)c(S)c1>>Cc1ccc2sc3c(=O)n(C)c(=O)c=3sc2c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080221322A1,ClCCCN1CCCC1>>ClCCCN1CCCC1,,COC(C)(C)C,O,Cl,[Na+].[OH-],val
US05721230,CC(C)[Mg]Cl.CON(C)C(=O)[C@H]1CCn2c(cc3ccccc32)C1>>CC(C)C(=O)[C@H]1CCn2c(cc3ccccc32)C1,,C1CCOC1,,[Cl-].[NH4+],,val
US20130059834A1,COC[C@H](C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12>>COC[C@H](C)NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US05436264,BrCC1CC1.OCCOc1ccccc1O>>OCCOc1ccccc1OCC1CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05250521,C[Sn](C)(C)Cl.Cc1ccc([Mg]Br)cc1>>Cc1cccc([Sn](C)(C)C)c1,,C1CCOC1,,[Cl-].[NH4+],,val
US05428041,C1CCNCC1.CS(C)=O.O=C(NC1NC(c2ccc(F)cc2)=NC1(C(F)(F)F)C(F)(F)F)c1ccc(F)cc1>>CN1C(c2ccc(F)cc2)=NC(C(F)(F)F)(C(F)(F)F)C1NC(=O)c1ccc(N2CCCCC2)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100197634A1,CCOc1nccc2c(Nc3c(Cl)cc(C#N)cc3Cl)nc3ccncc3c12.[NH3+]O>>CCOc1nccc2c(Nc3c(Cl)cc(C(N)=NO)cc3Cl)nc3ccncc3c12,,CCO,,CCN(CC)CC,,val
US05679700,CO[P@](=O)(CN(C(=O)CCCc1ccccc1)[C@@H](CC(C)C)C(=O)[N-]c1ccccc1)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(C)=O>>CC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)P(=O)(O)CN(C(=O)CCCc1ccccc1)[C@@H](CC(C)C)C(=O)Nc1ccccc1,,CO,,[Na+].[OH-],,val
US04552696,CS(=O)(=O)Cl.OCCSC(c1ccccc1)(c1ccccc1)c1ccccc1>>CS(=O)(=O)OCCSC(c1ccccc1)(c1ccccc1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20060122221A1,Cc1ccc(NC(=O)c2ccnc(N3CCCC3)c2)cc1B1OC(C)(C)C(C)(C)O1.Cc1noc2cc(Br)ccc12>>Cc1ccc(NC(=O)c2ccnc(N3CCCC3)c2)cc1-c1ccc2c(C)noc2c1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20040122089A1,C#CCCCC(=O)OC.OCC#CCCl>>COC(=O)CCCC#CCC#CCO,[Cu]I,CCOC(C)=O,CN(C)C=O,[I-].[K+],O=C([O-])O.[Na+],val
US20120252808A1,COC(=O)C#CC(=O)OC.Nc1ccccc1F>>COC(=O)/C=C(/Nc1ccccc1F)C(=O)OC,,CO,,,,val
US04101661,NS(=O)(=O)c1ccc(-c2ccc(CCl)c(=O)[nH]2)cc1.O=C(O)c1ccc(-c2ccc(S(=O)(=O)Nc3ccccn3)cc2)[nH]c1=O.O=S(Cl)Cl>>Cl.O=c1[nH]c(-c2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1CCl,,CN(C)C=O,,,,val
US20110263626A1,CC(=O)c1ccc(Oc2ccc(Cl)cc2F)cc1.NO>>CC(=NO)c1ccc(Oc2ccc(Cl)cc2F)cc1,,CCO,,,,val
US20130053409A1,COc1cc(N(C)CCN(C)C)c([N+](=O)[O-])cc1Nc1nccc(-c2cnn3ccccc23)n1>>COc1cc(N(C)CCN(C)C)c(N)cc1Nc1nccc(-c2cnn3ccccc23)n1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20040127574A1,O=C(O)C(Cc1ccc(Oc2ccccc2)cc1)C(O)c1ccc(F)cc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>O=C1NC(Cc2ccc(Oc3ccccc3)cc2)C(c2ccc(F)cc2)O1,,C1CCOC1,,CCN(CC)CC,O,val
US20120295903A1,CS(=O)(=O)Cl.OCC1CCCCN1Cc1ccccc1>>CS(=O)(=O)OCC1CCCCN1Cc1ccccc1,,ClCCl,,CCN(CC)CC,O,val
US20060247251A1,Cc1ccc(CCO)cc1.O=C1CCC(=O)N1Br>>Cc1ccc(CCBr)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06881733B1,CC1CC(c2cc(F)c(F)c3ccoc23)=CCN1C(=O)OC(C)(C)C.Cl>>CC1CC(c2cc(F)c(F)c3ccoc23)=CCN1.Cl,,C1COCCO1,,,,val
US05424280,O=C(Cl)COc1ccccc1Oc1cc(Oc2ccc(Cl)cc2Cl)ccc1[N+](=O)[O-].OCc1ccccc1>>O=C(COc1ccccc1Oc1cc(Oc2ccc(Cl)cc2Cl)ccc1[N+](=O)[O-])OCc1ccccc1,,C1CCOC1,ClCCl,CCN(CC)CC,O,val
US20060264415A1,CN(C)c1ccc(CC(=O)O)cc1.O=C(COCc1ccc(F)cc1)NCCC1CCNCC1>>CN(C)c1ccc(CC(=O)N2CCC(CCNC(=O)COCc3ccc(F)cc3)CC2)cc1,,CN(C)C=O,ClCCl,Cl,O=C(n1ccnc1)n1ccnc1,val
US20120101127A1,CC(C)(N)C(=O)O.COC(=O)c1cc(Cl)cc2c1NC(c1cccc(Br)c1)CC2(C)C>>CC1(C)CC(c2cccc(NC3(C(=O)O)CC3)c2)Nc2c(C(=O)O)cc(Cl)cc21,[Cu]I,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100113475A1,C=C(C)c1cnc(Nc2cc(C)nn2C)cc1Nc1ccccc1C(=O)NC>>CNC(=O)c1ccccc1Nc1cc(Nc2cc(C)nn2C)ncc1C(C)C,O=[Pt]=O,CCO,,N#N,,val
US20050004162A1,C=CCBr.Clc1ccc2scc(CCN3CC=C(c4c[nH]c5ccccc45)CC3)c2c1>>C=CCn1cc(C2=CCN(CCc3csc4ccc(Cl)cc34)CC2)c2ccccc21,,C1CCOC1,,CCCCCC,,val
US20010016207A1,CC(C)N1CCN(c2ccc(C(=O)O)cc2)CC1.N#CCNC(=O)C1(N)CCCCC1.On1nnc2ccccc21>>N#CCNC(=O)C1(NC(=O)c2ccc(N3CCN(Cc4ccccc4)CC3)cc2)CCCCC1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20120283297A1,N#Cc1cccc2[nH]ncc12.NO>>N=C(NO)c1cccc2[nH]ncc12,,CO,,Cl,O=C([O-])O.[Na+],val
US20030144285A1,Cc1ccccc1I.N#CCCCN1CCCC(CO)C1.O=C(O)C(F)(F)F>>Cc1ccccc1C(=O)CCCN1CCCC(CO)C1,,C1CCOC1,,CC#N,,val
US20030092749A1,Cc1cccc(-c2[nH]cnc2-c2ccc3c(c2)n(C)c(=O)n3-c2ccccc2)c1.Clc1cnccn1>>Cc1cccc(C2=C(c3ccc4c(c3)n(C)c(=O)n4-c3ccccc3)N(c3cnccn3)CN2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20150126490A1,COC(=O)c1ccccc1C(=O)ON1C(=O)CCC1=O.N[C@H](CO)c1ccccc1>>O=C1c2ccccc2C(=O)N1[C@H](CO)c1ccccc1,,O,,CC#N,,val
US05859007,BrBr.Cn1nc(CO)c2ccccc21>>Cn1nc(CBr)c2ccccc21,,CC#N,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06071950,Clc1cccc(COC2CCNC2)c1.N#CC(CCBr)(c1ccccc1)c1ccccc1>>N#CC(CCN1CCC(OCc2cccc(Cl)c2)C1)(c1ccccc1)c1ccccc1,,CCN(CC)CC,,CN1CCCC1=O,,val
US20100113475A1,CCNN.COCC(=O)CC#N>>CCn1nc(COC)cc1N,,CCO,,Cl,,val
US04209626,CN(C)C=C(C=O)c1cccc(C(F)(F)F)c1.NC(=O)CC(N)=O>>NC(=O)c1cc(-c2cccc(C(F)(F)F)c2)c[nH]c1=O,,CO,,C[O-].[Na+],,val
US20150141428A1,C#CC(C)NCc1cccc(-c2nccs2)c1.O=C=Nc1ccc(OC(F)(F)F)cc1>>C#CC(C)N(Cc1cccc(-c2nccs2)c1)C(=O)Nc1ccc(OC(F)(F)F)cc1,,ClCCl,,,,val
US20160244409A1,BrCc1ccc(Br)cc1.CC(=O)c1ccc(O)cc1>>CC(=O)c1ccc(OCc2ccc(Br)cc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120040981A1,CCN1c2cc(Br)sc2C(=O)NC12CCCC2.Cc1nn(C(=O)OC(C)(C)C)cc1B1OC(C)(C)C(C)(C)O1>>CCN1c2cc(-c3cn[nH]c3C)sc2C(=O)NC12CCCC2,,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20040224997A1,Fc1cc(Br)ccc1N=C=S.Nc1ccc(C(F)(F)F)cc1N>>Fc1cc(Br)ccc1Nc1nc2cc(C(F)(F)F)ccc2[nH]1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100113511A1,BrCCCCCCCCCCCCCc1cccnc1.c1cc2c(cn1)CCCC2>>[Br-].c1cncc(CCCCCCCCCCCCC[n+]2ccc3c(c2)CCCC3)c1,,CCOCC,,,,val
US04315939,CCOC(=O)CN/C(C)=C(/C)C(=O)OCC>>CCOC(=O)c1[nH]c(C)c(C)c1O,,CCO,,[Na],,val
US20150191431A1,CC(C)(C)OC(=O)NC[C@@H]1CC[C@H](O)CC1.Oc1ccnc2c(F)cccc12>>CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](Oc2ccnc3c(F)cccc23)CC1,,C1CCOC1,O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130053380A1,CS(=O)(=O)Cl.O=S(=O)(c1cccc2ncccc12)N1Cc2ccccc2COC[C@H]1CO>>CS(=O)(=O)OC[C@@H]1COCc2ccccc2CN1S(=O)(=O)c1cccc2cccnc12,,C1CCOC1,,CCOC(C)=O,,val
US20080261952A1,O=[N+]([O-])c1cccc(-c2cccc(N3CCCC3)n2)c1>>Nc1cccc(-c2cccc(N3CCCC3)n2)c1,[Pd],CCO,ClCCl,,,val
US20030153570A1,Cc1ccc(Cl)cc1-c1nc(Cl)nc(Cl)n1.Nc1ccc2cn[nH]c2c1>>Cc1ccc(Cl)cc1-c1nc(Cl)nc(Nc2ccc3cn[nH]c3c2)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080081818A1,COCC(=O)C(Br)C(=O)OC.NC(N)=S>>COCc1nc(N)sc1C(=O)OC,,CCO,,,,val
US20060014739A1,FC1CCCNC1.N#Cc1ccc(F)c2ccccc12>>N#Cc1ccc(N2CCCC(F)C2)c2ccccc12,,[Na+],[OH-],C1CCC2=NCCCN2CC1,Cl,val
US20080051418A1,CCCCI.CCOC(=O)CCc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1O>>CCCCOc1cc(Oc2ccc(C(F)(F)F)cn2)ccc1CCC(=O)OCC,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060148838A1,CCOC(=O)c1c(-c2cc(C)c(O)c(C)c2)c(C)n2c1-c1cc([N+](=O)[O-])c(OC)cc1CC2>>CCOC(=O)c1c(-c2cc(C)c(O)c(C)c2)c(C)n2c1-c1cc(N)c(OC)cc1CC2,[Pd],CCO,,[H][H],,val
US20160009704A1,CCOC(=O)CC(=O)OCC.Fc1cc(C(F)(F)F)ccn1>>CCOC(=O)C(C(=O)OCC)c1cc(C(F)(F)F)ccn1,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080200454A1,O=C(Cl)C(=O)Cl.O=C(O)c1ccc(Cl)c(I)c1>>O=C(Cl)c1ccc(Cl)c(I)c1,,ClCCl,,CN(C)C=O,,val
US20040186077A1,Cc1ncc(CO)c(C)c1OCc1ccccc1>>Cc1ncc(C=O)c(C)c1OCc1ccccc1,O=[Mn]=O,Cc1ccccc1,,,,val
US05843957,CC(C)CBr.COc1cccc(-c2c(NC(=O)Nc3c(C(C)C)cccc3C(C)C)c(=O)[nH]c3ncccc23)c1>>COc1cccc(-c2c(NC(=O)Nc3c(C(C)C)cccc3C(C)C)c(=O)n(CC(C)C)c3ncccc23)c1,,CN(C)C=O,O,[I-].[K+],,val
US20090176804A1,CO.O=C(Cl)C(=O)Cl.O=S(=O)(NC1CCCCC1)c1cc(-c2cc3c(F)cccc3[nH]2)ccc1Cl>>COC(=O)C(=O)c1c(-c2ccc(Cl)c(S(=O)(=O)NC3CCCCC3)c2)[nH]c2cccc(F)c12,,ClCCl,,,,val
US20100298343A1,Nc1ccc(C#Cc2ccccn2)cc1>>Nc1ccc(CCc2ccccn2)cc1,[Pd],CCOC(C)=O,,,,val
US20160024086A1,Cc1ccc(S(=O)(=O)OCC2CN(Cc3ccccc3)C(C)(C)C2)cc1.c1cc2nc(-c3cnn(C4CCCCO4)c3)ccc2[nH]1>>CC1(C)CC(Cn2ccc3nc(-c4cnn(C5CCCCO5)c4)ccc32)CN1Cc1ccccc1,,O,,CN(C)C=O,[H-].[Na+],val
US20060100229A1,CCCn1nc(C(=O)OCC)cc1CC(C)(C)S(C)(=O)=O.N>>CCCn1nc(C(N)=O)cc1CC(C)(C)S(C)(=O)=O,,CO,,,,val
US05141951,COc1cccc(-c2ccccc2)c1.O=C1CCCC(=O)O1>>O=C(O)CCCC(=O)c1ccc(-c2ccccc2)cc1O,,CC(Cl)Cl,O,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20030092140A1,CC(C)(C)OC(=O)NCC=Cc1ccc2oc(=O)[nH]c2c1>>NCC=Cc1ccc2oc(=O)[nH]c2c1,,O=C(O)C(F)(F)F,,,,val
US20080255114A1,COC(=O)c1cc(F)cc(O)c1[N+](=O)[O-]>>COC(=O)c1cc(F)cc(O)c1N,[Pd],CO,,CC(=O)O,,val
US20140249154A1,N#CC(Br)C(=O)c1ccccn1.NC(=S)Nc1ncccn1>>N#Cc1sc(Nc2ncccn2)nc1-c1ccccn1,,CCO,,Br,CCN(CC)CC,val
US20040082651A1,CC(=O)OC(C/C=C(/C)CCC[C@H](C)CO)(C(C)=O)C(=O)OC(C)(C)C>>CC(=O)OC(CC=C(C)CCC[C@H](C)CO)C(C)=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110319378A1,C=CC(=O)Cl.C=C[C@H](c1cccc(Cl)c1)[C@H](NC(C1CC1)C1CC1)c1ccc(Cl)cc1>>C=CC(=O)N(C(C1CC1)C1CC1)[C@H](c1ccc(Cl)cc1)[C@H](C=C)c1cccc(Cl)c1,,C1CCOC1,,CCN(CC)CC,CCOC(C)=O,val
US20120171245A1,CCOC(=O)C[C@@]1(O)CCC[C@H](Nc2nc(-c3cn(S(=O)(=O)c4ccc(C)cc4)c4ncc(Cl)cc34)ncc2F)C1>>O=C(O)C[C@@]1(O)CCC[C@H](Nc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)C1,,C1CCOC1,,Cl,[Li+].[OH-],val
US04560771,CC1Cc2cccc(S(N)(=O)=O)c2OS1(=O)=O.COc1cc(C)nc(N(C(=O)[O-])c2ccccc2)n1>>COc1cc(C)nc(NC(=O)NS(=O)(=O)c2cccc3c2OS(=O)(=O)C(C)C3)n1,,C1COCCO1,,C1CCC2=NCCCN2CC1,,val
US20030153577A1,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCN(Cc2ccc(Cl)c(Cl)c2)CC1>>CC(C)[C@H](N)C(=O)N1CCN(Cc2ccc(Cl)c(Cl)c2)CC1,,CO,,Cl,,val
US20110195954A1,N#C[Cu]C#N.O=C(c1cc(Cl)c(I)cn1)N1CCc2cc(F)ccc21>>N#Cc1cnc(C(=O)N2CCc3cc(F)ccc32)cc1Cl,,CN(C)C=O,,,,val
US20120077847A1,BrCc1ccncc1.O=C(NCc1nnc(-c2ccc(O)cc2)s1)C(O)CCCCCCc1ccccc1>>O=C(NCc1nnc(-c2ccc(OCc3ccncc3)cc2)s1)C(O)CCCCCCc1ccccc1,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20090093464A1,N#CBr.N#Cc1ccc(N2CCCCN2)c2ccccc12>>N#Cc1ccc(N2CCCCN2C#N)c2ccccc12,,CC#N,,CCN(C(C)C)C(C)C,,val
US20160218303A1,Cc1ccc(N)cc1C.N#Cc1cccc(F)c1[N+](=O)[O-]>>Cc1ccc(Nc2cccc(C#N)c2[N+](=O)[O-])cc1C,,O,,C1CCOC1,[H-].[Na+],val
US20040063754A1,CCOC(=O)CC(=O)c1ccc(Cl)nc1Cl.CCOC(OCC)OCC>>CCOC=C(C(=O)OCC)C(=O)c1ccc(Cl)nc1Cl,,CC(=O)OC(C)=O,,,,val
US20110269787A1,CC(C)N=C=NC(C)C.CN(C)C=O.COc1ccc2nc(NC(=S)n3ccnc3)sc2c1.ClC(Cl)Cl.O>>COc1ccc2nc(NC3=NCC4(CN5CCCC4C5)O3)sc2c1,,O,,Cl,,val
US20110039831A1,CC(c1c(F)cc2ncccc2c1F)c1cnc2ccc(N3CCNCC3)nn12.O=COc1ccc([N+](=O)[O-])cc1>>CC(c1c(F)cc2ncccc2c1F)c1cnc2ccc(N3CCN(C=O)CC3)nn12,,ClCCl,,CCN(CC)CC,,val
US20120101100A1,Nc1cc(Cl)nc(Cl)c1.OCC1CC1>>Nc1cc(Cl)nc(OCC2CC2)c1,,O,,[H-].[Na+],,val
US20110201592A1,COC(=O)[C@H]1C[C@H](N)CN1C(=O)OC(C)(C)C.COc1ccccc1-c1nc(Cl)c2ccccc2n1>>COC(=O)[C@H]1C[C@H](Nc2nc(-c3ccccc3OC)nc3ccccc23)CN1C(=O)OC(C)(C)C,,C1COCCO1,ClCCl,CCN(CC)CC,,val
US20140309227A1,COC(=O)c1cc(-c2ccc(F)cc2)c2ccc(C)c(F)c2n1.O=C1CCC(=O)N1Br>>COC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CBr)c(F)c2n1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20120171116A1,CC(C)(C)OC(=O)N1CCN(Cc2ccc(-c3ccccc3)cc2)CC1>>c1ccc(-c2ccc(CN3CCNCC3)cc2)cc1,,CO,,Cl,O=C([O-])O.[Na+],val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccc(OC)nc3)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3ccc(OC)nc3)c2)=C(C)C1=O,,CO,O,O=C([O-])O.[Na+],,val
US20100273744A1,BrP(Br)Br.Cc1ccc([N+](=O)[O-])cc1CO>>Cc1ccc([N+](=O)[O-])cc1CBr,,ClCCl,ClCCl,O=C([O-])O.[Na+],,val
US04632985,NNC(=O)c1cc(=O)c(OCc2ccccc2)c[nH]1.O=N[O-]>>[N-]=[N+]=NC(=O)c1cc(=O)c(OCc2ccccc2)c[nH]1,,O,,Cl,,val
US04503063,CCOC(=N)CC(O)(Cn1cncn1)c1ccc(Cl)cc1Cl>>NC(=O)CC(O)(Cn1cncn1)c1ccc(Cl)cc1Cl,,Clc1ccccc1Cl,,Cl,Cl,val
US08389523B2,CCOC(=O)C(=O)C(=O)OCC.Cc1ccc(-n2c(=O)c(C(=O)O)nc3cccnc32)cc1F.Cc1cccc(Nc2ccccc2N)n1>>CCOC(=O)c1nc2ccccc2n(-c2cccc(C)n2)c1=O,,Cc1ccccc1,,,,val
US20090093454A1,CN(C)[C@H]1CCNC1.Fc1cccc2nc(CN3CCC[C@H]4CCc5cccnc5[C@H]43)cn12>>CN(C)[C@H]1CCN(c2cccc3nc(CN4CCC[C@H]5CCc6cccnc6[C@H]54)cn23)C1,,CN1CCCC1=O,,O,,val
US20160244410A1,COc1ccc(CNC(=O)c2c(Oc3cccc(NC(C)=O)c3C)cc(=O)n(C)c2Nc2ccc(I)cc2F)cc1>>CC(=O)Nc1cccc(Oc2cc(=O)n(C)c(Nc3ccc(I)cc3F)c2C(N)=O)c1C,,COc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20050288283A1,CC(N)=O.O=C(O)/C=C/C(=O)O>>CC(N)=O.O=C(O)/C=C/C(=O)O,,CO,,,,val
US04978753,CCN(CC)CCCC#CC(=O)O.NC1=Nc2ccc([N+](=O)[O-])cc2C(c2c(F)cccc2F)=NC1>>CCN(CC)CCCc1cc(=O)nc2n1-c1ccc([N+](=O)[O-])cc1C(c1c(F)cccc1F)=NC2,,C1CCOC1,CN(C)C=O,O=C(n1ccnc1)n1ccnc1,,val
US20100120841A1,Nc1ccccc1NC1CCN(C2CC3CCCc4cccc2c43)CC1.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]c2ccccc2n1C1CCN(C2CC3CCCc4cccc2c43)CC1,,C1CCOC1,,O,,val
US20030087905A1,Nc1cccc(Oc2ccccc2)c1.O=Cc1cccc(C2CC=CO2)c1>>c1ccc(Oc2cccc(NCc3cccc(C4CCCO4)c3)c2)cc1,,ClCCCl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150025065A1,Br.CN=S1(=O)CC2CN(C(=O)OCc3ccccc3)CC2C1>>Br.CN=S1(=O)CC2CNCC2C1,,CC(=O)O,,,,val
US05426119,NCCc1ccc(C(=CCCCC(=O)O)c2cccnc2)cc1.O=S(=O)(Cl)c1ccc(F)cc1>>O=C(O)CCCC=C(c1ccc(CCNS(=O)(=O)c2ccc(F)cc2)cc1)c1cccnc1,,C1COCCO1,,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US20070208017A1,CC(C)(O)C#Cc1ccc2c(c1)c1cc(Cl)ccc1c1[nH]c(-c3c(C#N)cccc3C#N)nc21>>C=C(C)C#Cc1ccc2c(c1)c1cc(Cl)ccc1c1nc(-c3c(C#N)cccc3C#N)[nH]c21,,CCOC(C)=O,c1ccccc1,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US20040209847A1,O=C(CCCCC1(C(=O)O)CC1)CCCCC1(C(=O)O)CC1>>O=C(O)C1(CCCCC(O)CCCCC2(C(=O)O)CC2)CC1,,CC(C)O,O,Cl,[Na+].[OH-],val
US20120302578A1,CCOC(=O)c1cc2ccccc2[nH]1>>OCc1cc2ccccc2[nH]1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080269293A1,Cc1cc(Oc2ncccc2[N+](=O)[O-])n(-c2ccccc2)n1>>Cc1cc(Oc2ncccc2N)n(-c2ccccc2)n1,[Pd],CO,,C1CCOC1,,val
US05807866,O=C(OO)c1cccc(Cl)c1.OC/C=C/c1cccc(Br)c1>>OC[C@@H]1O[C@H]1c1cccc(Br)c1,,ClCCl,,,,val
US20090298744A1,CCCn1c(N)c(N)c(=O)n(CCC)c1=O.O=C(O)c1ccc(OCC2CC(=O)N(c3ccc(F)cc3)C2)cc1>>CCCn1c(N)c(NC(=O)c2ccc(OCC3CC(=O)N(c4ccc(F)cc4)C3)cc2)c(=O)n(CCC)c1=O,,CO,,CCN=C=NCCCN(C)C,Cl,val
US05665718,CCCBr.CCN(C(C)C)C(C)C.CN(C)C=O.CN1Cc2c(-c3nnc(CN)o3)ncn2-c2ccsc2C1=O>>CCCN(CCC)Cc1nnc(-c2ncn3c2CN(C)C(=O)c2sccc2-3)o1,,CN(C)C=O,,,,val
US20020169317A1,N#CCOc1c(Cl)ccc2c1c1cccc3c1n2C(c1ccccc1)CO3>>NCCOc1c(Cl)ccc2c1c1cccc3c1n2C(c1ccccc1)CO3,,C1CCOC1,,CO,,val
US20090093527A1,COC(=O)c1cnc(N2CCC(Oc3ccccc3C(F)(F)F)C2)s1>>O=C(O)c1cnc(N2CCC(Oc3ccccc3C(F)(F)F)C2)s1,,C1CCOC1,CO,[Na+].[OH-],,val
US20130338150A1,C[Mg]Br.NS(=O)(=O)C1(C(=O)C(F)(F)F)CC1>>CC(O)(C(F)(F)F)C1(S(N)(=O)=O)CC1,,C1CCOC1,CCOCC,[Cl-].[NH4+],,val
US20160039838A1,C1CO[C@H]2CNC[C@H]2O1.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3F)c2cc1NC(=O)/C=C/CBr>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3F)c2cc1NC(=O)/C=C/CN1C[C@H]2OCCO[C@H]2C1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,O,val
US20130210818A1,CC(C)(C)c1nc(Br)c(-c2ccnc(Cl)n2)[nH]1.C[C@@H](CN)NC(=O)OC(C)(C)C>>C[C@@H](CNc1nccc(-c2[nH]c(C(C)(C)C)nc2Br)n1)NC(=O)OC(C)(C)C,,CC#N,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20110152245A1,CC1(c2ccc(NC(=O)c3ccc(Cl)cc3)cc2)CCN(Cc2ccccc2)C1>>CC1(c2ccc(NC(=O)c3ccccc3)cc2)CCNC1,[Pd],CO,,O=C[O-].[NH4+],,val
US20060111355A1,CC(C)(C)c1ccc(-c2nc3c(N4CCN(CCOc5cccc(N)c5N)CC4)cccc3[nH]2)cc1.N#CBr>>CC(C)(C)c1ccc(-c2nc3c(N4CCN(CCOc5cccc6[nH]c(=N)[nH]c56)CC4)cccc3[nH]2)cc1,,CO,,[Na+].[OH-],,val
US04710579,CCCCCCCCCCCCCCCCCCOCC(CO)OC(=O)c1ccccc1.Cc1ccc(S(=O)(=O)[O-])cc1.O=P(Cl)(Cl)Cl.OCCC[n+]1ccccc1>>CCCCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCCC[n+]1ccccc1)OC(=O)c1ccccc1,,ClC(Cl)Cl,c1ccncc1,CCN(CC)CC,O=C([O-])O.[Na+],val
US20110152261A1,CS(=O)(=O)Cl.Cc1ncc(Cl)cc1C(=O)N[C@@H]1CC[C@@H](CO)CC1>>Cc1ncc(Cl)cc1C(=O)N[C@@H]1CC[C@@H](COS(C)(=O)=O)CC1,,ClCCl,,c1ccncc1,,val
US20090143439A1,COc1ccc2scc(S(=O)(=O)Cl)c2c1.N>>COc1ccc2scc(S(N)(=O)=O)c2c1,,C1CCOC1,,,,val
US20150175557A1,CC(F)(F)COc1ccc(CCN)cc1.CC1(C)C[C@H](Nc2nc(S(C)(=O)=O)ncc2C#N)CC[C@@H]1O>>CC(F)(F)COc1ccc(CCNc2ncc(C#N)c(N[C@@H]3CC[C@H](O)C(C)(C)C3)n2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20040087621A1,COc1ccc(C#N)cc1/C=C/C(=O)N[C@H](CC(=O)OCc1ccccc1)CN1CCC(Oc2ccc(F)cc2)CC1>>COc1ccc(C#N)cc1/C=C/C(=O)N[C@H](CC(=O)O)CN1CCC(Oc2ccc(F)cc2)CC1,,CO,,[Na+].[OH-],,val
US05756510,COC(=O)c1cccc2oc(C(C)(C)C)nc12.N>>CC(C)(C)c1nc2c(C(N)=O)cccc2o1,,CO,,,,val
US20050107364A1,CCCC(=O)O.O=C=NS(=O)(=O)Cl>>CCCC(=O)NS(=O)(=O)Cl,,c1ccccc1,,,,val
US04260611,CN(C)CCCN.COc1cc2c(-c3ccc(Cl)cc3)nc(Cl)c(C=O)c2cc1OC>>COc1cc2c(-c3ccc(Cl)cc3)nc(Cl)c(CCCN(C)C)c2c(CN)c1OC,,CO,,CN(C)C=O,,val
US20100172867A1,O=C(N[C@@H]1CNc2ccccc2C1)[C@@H](O)c1ccccc1.O=Cc1ccc(F)cc1>>O=C(N[C@H]1Cc2ccccc2N(Cc2ccc(F)cc2)C1)[C@@H](O)c1ccccc1,,ClCCCl,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20160024110A1,C=C(C)COC(=O)CC(=O)CCl.CCOC(OCC)OCC>>C=C(C)COC(=O)/C=C(\CCl)OCC,O=S(=O)(O)O,ClC(Cl)Cl,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20080004325A1,COC(=O)CN(c1csc(-c2cccc(N)c2)c1C)S(=O)(=O)NC(=O)OC(C)(C)C.O=C1CCN(S(=O)(=O)Cc2ccccc2)CC1>>Cc1c(N2CC(=O)NS2(=O)=O)csc1-c1cccc(NC2CCN(S(=O)(=O)Cc3ccccc3)CC2)c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20160159815A1,COc1cc(C(=O)N2CC[C@]3(c4cccc(F)c4)OCO[C@@H]3C2)ccc1NCC1CC(F)(F)C1.CSCC[C@H](N)C(=O)O>>COc1cc(C(=O)N2CC[C@]3(c4cccc(F)c4)OCO[C@@H]3C2)ccc1N(C)CC1CC(F)(F)C1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20080096883A1,Cc1ccc(C(=O)Cl)cc1Br.Nc1ccc(C=O)c(C(F)(F)F)c1>>Cc1ccc(C(=O)Nc2ccc(C=O)c(C(F)(F)F)c2)cc1Br,,ClCCl,,CCN(CC)CC,,val
US05246931,C=C1CC(NC(=O)OCc2ccccc2)C1.CO>>O=C1CC(NC(=O)OCc2ccccc2)C1,,ClCCl,,,,val
US20150291604A1,CC(C)(CO)NC(=O)OC(C)(C)C.COc1ccc(C(=O)Cl)cc1>>COc1ccc(C(=O)OCC(C)(C)NC(=O)OC(C)(C)C)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150175602A1,CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCNC2.CCC(=O)OC(=O)CC>>CCC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04880841,COc1ccc(CCC(C)N)cc1.CSc1cc(C2CO2)ccc1C>>COc1ccc(CCC(C)NCC(O)c2ccc(C)c(SC)c2)cc1,,c1ccccc1,,,,val
US20140031285A1,CCOC(=O)CCCOc1ccc(C(C)=O)cc1OC.O=[N+]([O-])O>>CCOC(=O)CCCOc1cc([N+](=O)[O-])c(C(C)=O)cc1OC,,O,,,,val
US03948596,COc1cc(N)ccc1Cl>>Nc1ccc(Cl)c(O)c1,,CC(=O)O,,Br,,val
US20020133015A1,COC(=O)[C@H](Cc1ccc(-c2c(C)ccn(C)c2=O)cc1)NC(=O)c1c(C)cccc1Cl>>Cc1cccc(Cl)c1C(=O)N[C@@H](Cc1ccc(-c2c(C)ccn(C)c2=O)cc1)C(=O)O,,CCO,,[Na+].[OH-],,val
US20110098293A1,COC[C@H](C)N.O=Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1>>COC[C@H](C)NCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20090247502A1,COC(=O)c1cnc2c(c1)NCCO2.O=S(=O)(Cl)c1ccccc1>>COC(=O)c1cnc2c(c1)N(S(=O)(=O)c1ccccc1)CCO2,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130065905A1,CCCS(=O)(=O)N(COCC[Si](C)(C)C)c1nc2ccccc2nc1OC(c1cc[n+]([O-])cc1)C(F)(F)F.O=S(=O)(n1ccnc1)n1ccnc1>>CCCS(=O)(=O)N(COCC[Si](C)(C)C)c1nc2ccccc2nc1OC(c1ccnc(-n2ccnc2)c1)C(F)(F)F,,Cc1ccccc1,,[Na+].[OH-],,val
US20120214762A1,Nc1ncc([N+](=O)[O-])c(=O)[nH]1.O=P(Cl)(Cl)Cl>>NC1=NC=C([N+](=O)[O-])C(Cl)N1,,ClCCl,,,,val
US20050043395A1,CCOC(=O)c1cc(OC)c(OCC2CCN(C)CC2)cc1N.N=CN>>COc1cc2c(=O)[nH]cnc2cc1OCC1CCN(C)CC1,,COCCO,,CC(=O)O,,val
US04377580,CCc1ccc(NC(N)=O)c(C#N)c1>>CCc1ccc2nc(O)nc(N)c2c1,,CO,,O,[Na],val
US20160000760A1,CC(=O)Cl.CC(C)(C)OC(=O)N1CCC(S(=O)(=O)c2ccc(-c3c(Cl)cc(Nc4n[nH]c(N)n4)cc3C(F)(F)F)cc2)CC1>>Cl.Nc1nc(Nc2cc(Cl)c(-c3ccc(S(=O)(=O)C4CCNCC4)cc3)c(C(F)(F)F)c2)n[nH]1,,CO,,,,val
US20060211678A1,O=[N+]([O-])c1ccn(CCc2ccccc2)n1>>Nc1ccn(CCc2ccccc2)n1,[Pd],CCO,CCOC(C)=O,,,val
US20130217680A1,CCOC(=O)CC(=O)OC(C)(C)C.O=[N+]([O-])c1ccc(Cl)cn1>>CCOC(=O)C(C(=O)OC(C)(C)C)c1ccc([N+](=O)[O-])nc1,,CN(C)C=O,,[H-].[Na+],,val
US04584293,COc1cc2c(cc1OC)CC(=O)N(CCC=O)C=C2.NC1CCc2ccccc2C1>>COc1cc2c(cc1OC)CC(=O)N(CCCNC1CCc3ccccc3C1)CC2,[Pd],CCO,,,,val
US20100273837A1,CCOC(=O)c1nc(-c2ccc(Cl)cc2OCc2ccccc2)ns1>>OCc1nc(-c2ccc(Cl)cc2OCc2ccccc2)ns1,,CCO,,[BH4-].[Na+],,val
US20160130226A1,Brc1ccc(-c2ccc(Br)cc2)cc1.CC1NC=CN1>>Cc1nccn1-c1ccc(-c2ccc(Br)cc2)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140163009A1,C(=C/C1CCCCC1)\c1ccccc1.CCOC(=O)C=[N+]=[N-]>>CCOC(=O)[C@@H]1[C@H](C2CCCCC2)[C@H]1c1ccccc1,,ClCCl,,,,val
US20090030041A1,C=C(C(=O)OCc1ccccc1)c1ccccc1.CC(C)(C)OC(=O)Nc1cccc(NC2CCNCC2)c1>>CC(C)(C)OC(=O)Nc1cccc(NC2CCN(CC(C(=O)OCc3ccccc3)c3ccccc3)CC2)c1,,CC#N,,,,val
US20110112122A1,CI.Cc1cc(Br)c(C(=O)OC(C)(C)C)c2c3c([nH]c12)CC1CCC3N1>>Cc1cc(Br)c(C(=O)OC(C)(C)C)c2c3c(n(C)c12)CC1CCC3N1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US03968138,CCN(CC)c1c([N+](=O)[O-])cc(C#N)c(Cl)c1[N+](=O)[O-].N>>CCN(CC)c1c([N+](=O)[O-])cc(C#N)c(N)c1[N+](=O)[O-],,CCO,,COCCOC,,val
US20150284405A1,COC(=O)[C@]1(C)CCC(=O)N1C(=O)OC(C)(C)C>>COC(=O)[C@]1(C)CCC(=O)N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US03951988,CCO.CCOC(=O)C=C1NCCN1.CCOC(=O)CC(=O)C=C1CC=Cc2ccccc21>>CCOC(=O)C1=C(C)N2CCNC2=C(C(=O)OCC)C1c1cccc2ccccc12,,CCO,,,,val
US20070292926A1,C[C@@H](CCCOS(C)(=O)=O)OS(C)(=O)=O.NCc1ccccc1>>C[C@@H]1CCCN1Cc1ccccc1,,CCOC(C)=O,,[Na+].[OH-],,val
US20130072467A1,CN(C)C(=O)[C@@H](N)C(C)(C)O.O=C1NC(=S)CS1>>CN(C)C(=O)[C@@H](NC1=NC(=O)SC1)C(C)(C)O,,CCO,,,,val
US20160115158A1,Nc1cccnc1O.O=S(=O)(Cl)c1cnc(Cl)c(Br)c1>>O=S(=O)(Nc1cccnc1O)c1cnc(Cl)c(Br)c1,,CO,,,,val
US20130172323A1,CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(C=Cc4ccccc4)cc3)oc2c1>>CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(CCc4ccccc4)cc3)oc2c1,[Pd],CO,,[H][H],,val
US20070003539A1,COc1ccc(S(N)(=O)=O)cc1CN=[N+]=[N-]>>COc1ccc(S(N)(=O)=O)cc1CN,[Pd],CO,,,,val
US20100317651A1,CC(Cl)OC(=O)Cl.C[C@@H](Oc1cnc2c(n1)OCCN(Cc1ccccc1)C2)C1CC1>>C[C@@H](Oc1cnc2c(n1)OCCNC2)C1CC1.Cl,,Cc1ccccc1,,,,val
US20130217680A1,C=Cc1c(CCN2CCN(C(=O)OC(C)(C)C)CC2)ccc2c1COC2=O>>CCc1c(CCN2CCN(C(=O)OC(C)(C)C)CC2)ccc2c1COC2=O,[Pd],CO,,,,val
US20150018363A1,CNc1cc(-n2ccc(OCc3ccc(Cl)cc3)cc2=O)ccc1N.O=C(O)C1CCC1>>Cn1c(C2CCC2)nc2ccc(-n3ccc(OCc4ccc(Cl)cc4)cc3=O)cc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05312929,CCOC(=O)C(C)(C)N(CC(C)=O)C(=O)Cc1ccccc1>>CCOC(=O)C(C)(C)N1CC(C)=C(c2ccccc2)C1=O,,CCO,,C[O-].[Na+],,val
US20090221578A1,CCOC(=O)Cc1c(C)[nH]c2ccc(F)cc12.CS(=O)(=O)c1ccc(CBr)c(C(F)(F)F)c1>>CCOC(=O)Cc1c(C)n(Cc2ccc(S(C)(=O)=O)cc2C(F)(F)F)c2ccc(F)cc12,,CS(C)=O,O,[H-].[Na+],,val
US20100292238A1,COc1ccc(C2=C(c3ccc(O)cc3)C(=O)C(C)(C)O2)cc1.ClCc1ccc2nccn2n1>>COc1ccc(C2=C(c3ccc(OCc4ccc5nccn5n4)cc3)C(=O)C(C)(C)O2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20100022529A1,CC(C)(C)OC(=O)Nc1ccc(-c2cc3c(cnn3C3CCCCO3)cc2OCc2ccccc2)cn1>>CC(C)(C)OC(=O)Nc1ccc(-c2cc3c(cnn3C3CCCCO3)cc2O)cn1,[Pd],CCO,CCOC(C)=O,,,val
US20140235612A1,CCCN.CCOC(=O)c1nc2cccnc2n1-c1ccc(Cl)c(F)c1>>CCCNC(=O)c1nc2cccnc2n1-c1ccc(Cl)c(F)c1,,CCO,,,,val
US20160214924A1,CC(=O)[C@H]1CC(=O)c2ccccc2[C@@H]1O>>CC(=O)c1cc(O)c2ccccc2c1,,CO,,Cl,,val
US05344843,CCC(C)(C)C(=O)Oc1cccc2ccc(OCCOc3ccc(C(=O)C(=O)OC)cc3)cc12>>CCC(C)(C)C(=O)Oc1cccc2ccc(OCCOc3ccc(C(=O)C(=O)O)cc3)cc12,,CO,,Cl,[Na+].[OH-],val
US20020028807A1,CCN1c2ncc(CCO)cc2C(=O)Nc2c(C)cc(Cl)nc21.Oc1cccc2ncccc12>>CCN1c2ncc(CCOc3cccc4ncccc34)cc2C(=O)Nc2c(C)cc(Cl)nc21,,C1CCOC1,CCOC(C)=O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080188528A1,BrCc1ccccc1.O=C(O)c1ccnc(O)c1>>O=C(O)c1ccn(Cc2ccccc2)c(=O)c1,,CO,,[K+].[OH-],,val
US20160221972A1,COC(=O)c1ccc2c(c1)OC[C@H](C)NC2.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OC1CCC1>>COC(=O)c1ccc2c(c1)OC[C@H](C)N(C(=O)OC1CCC1)C2,,C1CCOC1,,CCN(CC)CC,,val
US04654347,CC(=O)c1cccc(N)c1.CCOC(=O)Cl>>CCOC(=O)Nc1cccc(C(C)=O)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040122235A1,Cc1ccc(NC(=O)Nc2nc(CN)cs2)c(C(=O)C2CCCC2)c1.N=C(N)n1cccc1>>Cc1ccc(NC(=O)Nc2nc(CNC(=N)N)cs2)c(C(=O)C2CCCC2)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US06602889B1,CI.Fc1ccc(-n2ccc3cc(-c4nnn[nH]4)ccc32)cc1>>Cn1nnc(-c2ccc3c(ccn3-c3ccc(F)cc3)c2)n1,,CN1CCCC1=O,,,,val
US05688823,CC(C)(C)[Si](C)(C)Cl.C[C@H](CO)NC(=O)OCc1ccccc1>>C[C@H](CO[Si](C)(C)C(C)(C)C)NC(=O)OCc1ccccc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20060252758A1,CCCCCN1C(=O)C(CO)(c2cc3c(cc2O)OCO3)c2ncccc21>>CCCCCN1C(=O)C2(COc3cc4c(cc32)OCO4)c2ncccc21,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040009995A1,CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cnc(Cl)c(Br)c1.NCc1ccncc1>>CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cnc(NCc2ccncc2)c(Br)c1,,C1CCOC1,,,,val
US20030199440A1,O=C1CCC(=O)N1Cl.O=c1[nH]ccc2ccc(Br)cc12>>O=c1[nH]cc(Cl)c2ccc(Br)cc12,,CC#N,,,,val
US03952031,CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC=C(C(C)=O)[C@@]4(C)CC(=O)[C@@H]32)C1>>CC(=O)C1=CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C,,C1COCCO1,O,[K+].[OH-],,val
US20030045511A1,CC1(C)OC(=O)Nc2ccc(Br)cc21.[O-]B([O-])[O-]>>CC1(C)OC(=O)Nc2ccc(B(O)O)cc21,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20100280043A1,CC(C)(C)OC(=O)N1C(=O)CCC1(C)C.CO>>COC1CCC(C)(C)N1C(=O)OC(C)(C)C,,CCOCC,CO,CC(C)C[AlH]CC(C)C,,val
US04391821,CC(C)N.c1ccc(C2COc3cc(OCC4CO4)ccc3C2)cc1>>CC(C)NCC(O)COc1ccc2c(c1)OCC(c1ccccc1)C2,,CCO,,,,val
US20090137595A1,CC1=NN(C)C(C(=O)O)C1.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)ccc1F>>CC1=NN(C)C(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2F)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130116216A1,C=CC(=O)Cl.Nc1ccc(S(=O)(=O)N2CCN(C(=O)OCc3ccccc3)CC2)c(C(F)(F)F)c1>>C=CC(=O)Nc1ccc(S(=O)(=O)N2CCN(C(=O)OCc3ccccc3)CC2)c(C(F)(F)F)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US06476030B1,Cc1ccc(S(=O)(=O)Oc2nn3c(-c4cc(F)ccc4F)nncc3c2C(C)(C)C)cc1.Cn1ncnc1CO>>Cn1ncnc1COc1nn2c(-c3cc(F)ccc3F)nncc2c1C(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20080306076A1,COc1ccccc1C(=O)Nc1nc(O)c2ncn([C@@H]3O[C@H](CO[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H]3O[Si](C)(C)C)c2n1>>COc1ccccc1C(=O)Nc1nc(O)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1,,CCOCC,,O=C(O)C(F)(F)F,,val
US20020094989A1,CC(C)(C)OC(=O)N1CCC(CCI)CC1.Fc1ccc(S)cc1>>CC(C)(C)OC(=O)N1CCC(CCSc2ccc(F)cc2)CC1,,C1CCOC1,CCOCC,[H-].[Na+],,val
US20100029688A1,CC(C)(C)OC(=O)N1CCC(C2CCN(c3ccc([N+](=O)[O-])cc3)CC2)CC1>>CC(C)(C)OC(=O)N1CCC(C2CCN(c3ccc(N)cc3)CC2)CC1,[Pd],CCO,CCOC(C)=O,,,val
US20100125058A1,COC(=O)Cc1cc(OCc2ccccc2)c2cc(F)ccc2c1C>>COC(=O)Cc1cc(O)c2cc(F)ccc2c1C,[Pd],CO,,,,val
US20040010009A1,CC(C)(C)OC(=O)N1CCC(O)CC1.Cc1cc([N+](=O)[O-])cc(C)c1O>>Cc1cc([N+](=O)[O-])cc(C)c1OC1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020156081A1,Clc1ncnc2[nH]nc(Br)c12.OC1CCC2(CC1)OCCO2>>Clc1ncnc2c1c(Br)nn2C1CCC2(CC1)OCCO2,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060166933A1,CC(C)(C)[Si](C)(C)OCCc1cc(=O)oc2cc(O[Si](C)(C)C(C)(C)C)ccc12>>CC(C)(C)[Si](C)(C)OCCC1=CC(O)Oc2cc(O[Si](C)(C)C(C)(C)C)ccc21,,Cc1ccccc1,,CC(C)C[AlH]CC(C)C,,val
US20140213781A1,COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)OC(C)(C)C>>COC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)OC(C)(C)C,[Pd],CC(=O)O,,,,val
US20100120859A1,COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@@H]2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)cc(OCc2ccc(C#N)cc2)c1.C[Si](C)(C)N=[N+]=[N-]>>COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@@H]2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)cc(OCc2ccc(-c3nnn[nH]3)cc2)c1,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US04517196,CCOC(=O)C(=O)Cl.NC1N=C2C(=Cc3ccccc32)S1>>CCOC(=O)C(=O)NC1N=C2C(=Cc3ccccc32)S1,,ClCCl,,c1ccncc1,,val
US04931083,CCOC(=O)C(C)Br.S=c1ncn(-c2ccc(Cl)c(Cl)c2)[nH]1>>CCOC(=O)C(C)Sc1ncn(-c2ccc(Cl)c(Cl)c2)n1,,CCO,CS(C)=O,[Na],,val
US20080113923A1,CC(C)CCCC(C)CCCC(C)CCO.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCCC(C)CCCC(C)CCCC(C)C)cc1,,ClCCl,,c1ccncc1,,val
US20130102584A1,O=C(O)c1ccc(-c2ccccc2)cc1.c1cc(C2CNC2)ccn1>>O=C(c1ccc(-c2ccccc2)cc1)N1CC(c2ccncc2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06060455,CCCCCCCC/C=C\CCCCCCCC(=O)OCCC(NC(=O)OC(C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC>>CCCCCCCC/C=C\CCCCCCCC(=O)OCCC(N)OC(=O)CCCCCCC/C=C\CCCCCCCC,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070299092A1,CNC1CCCCC1.COCCOc1cc2ncnc(NC3=CC(=O)C(Cl)=CC3=O)c2cc1OC>>COCCOc1cc2ncnc(NC3=CC(=O)C(N(C)C4CCCCC4)=CC3=O)c2cc1OC,,COCCOC,,,,val
US20150315182A1,CC#CC(=O)OC.N[n+]1ccccc1>>Cc1nn2ccccc2c1C(=O)O,,CN(C)C=O,,[I-].[K+],,val
US20100093718A1,N#Cc1ccnc(N)c1.O=CCCl>>N#Cc1ccn2ccnc2c1,,CCO,,O=C([O-])O.[Na+],,val
US20040121965A1,COc1cccc(C(C)(C)C(=O)C(=O)O)c1>>CC(C)(C(=O)C(=O)O)c1cccc(O)c1,,ClCCl,,BrB(Br)Br,,val
US20060047001A1,COC(Cl)Cl.Fc1cccc2ccsc12>>O=Cc1csc2c(F)cccc12,Cl[Ti](Cl)(Cl)Cl,ClCCl,,O=C([O-])O.[Na+],,val
US20030096857A1,CC(=O)OC(C)OC(=O)Oc1ccc([N+](=O)[O-])cc1.CC(C)(C)OC[C@H](N)C(=O)N1CCC[C@H]1C#N>>CC(=O)OC(C)OC(=O)N[C@@H](COC(C)(C)C)C(=O)N1CCC[C@H]1C#N,,ClCCl,,CCN(CC)CC,Cl,val
US20060111402A1,BrCc1cccnc1.FC(F)(F)Cc1nc2cc(Cl)c(Cl)cc2[nH]1>>FC(F)(F)Cc1nc2cc(Cl)c(Cl)cc2n1Cc1cccnc1,,CN(C)C=O,,Br,O=C([O-])[O-].[K+].[K+],val
US20020193402A1,C[C@H](O[C@@H]1CC[C@H]2[C@H](C(=O)OC(C)(C)C)C[C@]1(c1ccccc1)N2Cc1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>C[C@H](O[C@@H]1CC[C@H]2[C@H](C(=O)O)C[C@]1(c1ccccc1)N2Cc1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060223799A1,CCOC(=O)c1cc2c(ncn2-c2cccc(-c3ccsc3)c2)[nH]1>>OCc1cc2c(ncn2-c2cccc(-c3ccsc3)c2)[nH]1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05264415,CCCCC(Cn1cncn1)(C(=O)O)c1ccc(Cl)cc1.CCI>>CCCCC(Cn1cncn1)(C(=O)OCC)c1ccc(Cl)cc1,,CCOC(C)=O,CN(C)C=O,CO,[Na+].[OH-],val
US20120122842A1,CCCNC(=O)c1ccc(NC(=O)N2Cc3ccc(Br)cc3C2)cc1.OB(O)c1cc[nH]n1>>CCCNC(=O)c1ccc(NC(=O)N2Cc3ccc(-c4cc[nH]n4)cc3C2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20070299053A1,CI.O=C1Cc2ccccc2CCN1>>CN1CCc2ccccc2CC1=O,,CN(C)C=O,,[H-].[Na+],,val
US20140315888A1,CC(C)(C)OC(=O)NC1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1>>NC1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150158851A1,N.O=[N+]([O-])c1cnn(C(c2ccnc(Cl)c2)C2CCOCC2)c1>>Nc1cnn(C(c2ccnc(N)c2)C2CCOCC2)c1,[Cu]I,OCCO,,O,,val
US20110178070A1,CC(=O)Nc1nc2cnc(-c3cnc(Cl)c(N(S(C)(=O)=O)S(C)(=O)=O)c3)nc2s1>>CC(=O)Nc1nc2cnc(-c3cnc(Cl)c(NS(C)(=O)=O)c3)nc2s1,,CO,N,,,val
US20150197512A1,CC(C)(C)[Si](C)(C)Cl.OCCCc1cccs1>>CC(C)(C)[Si](C)(C)OCCCc1cccs1,,ClCCl,,O,c1c[nH]cn1,val
US04472305,CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1ccccc1)C(N)=O>>CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H]1CCCCN1)c1ccccc1)C(N)=O,,CCOC(C)=O,,Cl,,val
US04009175,Fc1ccc2c(c1)C(c1ccccc1)=NCc1nnc(CCl)n1-2.O=C1c2ccccc2C(=O)N1O>>O=C1c2ccccc2C(=O)N1OCc1nnc2n1-c1ccc(F)cc1C(c1ccccc1)=NC2,,CC(=O)N(C)C,,CCN(CC)CC,,val
US20080262056A1,CC(C)N1C(=O)Cc2cc(NC[C@@H](O)CNC(=O)OC(C)(C)C)cc(F)c21.O=C(Cl)Cl>>CC(C)N1C(=O)Cc2cc(N3C[C@H](CNC(=O)OC(C)(C)C)OC3=O)cc(F)c21,,ClCCl,,CCN(CC)CC,,val
US04031226,O=C(NCCBr)c1ccccc1[N+](=O)[O-].O=C1NCN(c2ccccc2)C12CCNCC2>>Br.O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccccc1[N+](=O)[O-],,CN(C)C=O,,,,val
US05106871,COCOc1ccc(C=CC(=O)c2c(OCOC)cc(OCOC)c(CC=C(C)C)c2OC(C)=O)cc1>>COCOc1ccc(CCC(=O)c2c(OCOC)cc(OCOC)c(CC=C(C)C)c2OC(C)=O)cc1,[Pd],CCO,,[H][H],,val
US20020028834A1,CC(=O)Cl.COc1ccc2c(c1)NC(=O)CC2>>CC(=O)c1cc2c(cc1O)NC(=O)CC2,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US06350749B1,COc1ccc(Cl)cc1C1CC(=O)c2c(C)ccnc2C1.Cl.N=C(N)NN>>COc1ccc(Cl)cc1C1CC(=NNC(=N)N)c2c(C)ccnc2C1.Cl,,CCO,,Cl,O,val
US20150344437A1,COc1c(-c2noc(-c3ccccc3)n2)c(C)nn1C>>Cc1nn(C)c(O)c1-c1noc(-c2ccccc2)n1,,ClCCl,,BrB(Br)Br,,val
US20140275003A1,CI.O=c1[nH]cc(Br)nc1N1CCOCC1>>O=c1[nH]cc(Br)cc1N1CCOCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040167171A1,COc1ccc(N2CCN(c3c(C)c(C)c4c(c3C)C(O)(c3ccc(OC(F)(F)F)cc3)C(C)(C)O4)CC2)cc1>>COc1ccc(N2CCN(c3c(C)c(C)c4c(c3C)C(c3ccc(OC(F)(F)F)cc3)C(C)(C)O4)CC2)cc1,,CCO,,,,val
US20040033995A1,COC(=O)CC[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CCCCCCc1ccccc1>>O=C(O)CC[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CCCCCCc1ccccc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20050282819A1,CNC1C(C)(C)c2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc2C1(C)C.CS(=O)(=O)O>>CNC1C(C)(C)c2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc2C1(C)C.CS(=O)(=O)O,,CCOC(C)=O,,,,val
US20070105904A1,C#Cc1ccc(N)nc1N.Cc1ccc(Cc2ccc(CC(Cl)=NO)s2)cc1>>Cc1ccc(Cc2ccc(Cc3cc(-c4ccc(N)nc4N)on3)s2)cc1,,O,,C1CCOC1,CCN(CC)CC,val
US20060173058A1,COCCOCOc1cc(N)ccc1C#N.O=Cc1ccc(F)cc1>>COCCOCOc1cc(NCc2ccc(F)cc2)ccc1C#N,,ClCCCl,,[Na+].[OH-],,val
US07250518B2,CCOC(=O)Cc1ccc(CNC(=O)c2cccnc2Oc2ccc(F)cc2)c(F)c1>>O=C(O)Cc1ccc(CNC(=O)c2cccnc2Oc2ccc(F)cc2)c(F)c1,,C1CCOC1,O,[Li+].[OH-],,val
US05998462,C=Cc1ccc2[nH]cc(C(=O)[C@H]3CCCN3C(=O)OCc3ccccc3)c2c1>>C=Cc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100272680A1,CC(C)(C)[Si](C)(C)O[C@@H]1CN(Cc2ccccc2)CC[C@@H]1NC(=O)OCCCl>>CC(C)(C)[Si](C)(C)O[C@@H]1CN(Cc2ccccc2)CC[C@@H]1N1CCOC1=O,,CN(C)C=O,,[H-].[Na+],,val
US20150284409A1,C=CCCCO[C@@H](CC)[C@H](NC(=O)OC(C)(C)C)C(=O)OC>>C=CCCCO[C@@H](CC)[C@H](NC(=O)OC(C)(C)C)C(=O)O,,CO,,C1CCOC1,[Li+].[OH-],val
US20060281784A1,CC(C)CCN(CCC(C)C)C(=O)c1ccc([N+](=O)[O-])c(NCCCN2CCCCC2)c1>>CC(C)CCN(CCC(C)C)C(=O)c1ccc(N)c(NCCCN2CCCCC2)c1,[Pd],CCO,CCOC(C)=O,,,val
US20080269208A1,COC(=O)C1CS(=O)(=O)CCN1C(=O)OC(C)(C)C>>COC(=O)C1CS(=O)(=O)CCN1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20090130097A1,C#CC[C@@H](NC(=O)OC(C)(C)C)c1nc2cc(Cl)ccc2c(=O)n1Nc1ccccc1>>C#CC[C@@H](N)c1nc2cc(Cl)ccc2c(=O)n1Nc1ccccc1,,C1COCCO1,CO,Cl,,val
US20160024110A1,CC(C)O.COC(=O)CC(=O)CCl>>CC(C)OC(=O)CC(=O)CCl,CN(C)c1ccncc1,Cc1ccccc1,,,,val
US06043254,CC(=O)N1C(=O)C(=C(O)c2ccc(C)cc2)c2cc([N+](=O)[O-])ccc21.ClP(Cl)(Cl)(Cl)Cl>>CC(=O)N1C(=O)C(=C(Cl)c2ccc(C)cc2)c2cc([N+](=O)[O-])ccc21,,Cc1ccccc1,,,,val
US20130331419A1,CCC(/C=C/C#N)(c1ccc(Cl)cc1)n1ncc2c(N)cccc21.CS(=O)(=O)Cl>>CCC(/C=C/C#N)(c1ccc(Cl)cc1)n1ncc2c(NS(C)(=O)=O)cccc21,,ClCCl,,CN1CCOCC1,,val
US20140242028A1,O=[N+]([O-])c1cc(Cl)c(Sc2cccc(C(F)(F)F)c2)c(Cl)c1>>Nc1cc(Cl)c(Sc2cccc(C(F)(F)F)c2)c(Cl)c1,[Fe],O,,CO,[Cl-].[NH4+],val
US20120220589A1,COC(=O)c1ccc2[nH]c(=O)c(Cl)nc2c1.N#Cc1ccc2c(c1)CCCN2>>COC(=O)c1ccc2[nH]c(=O)c(N3CCCc4cc(C#N)ccc43)nc2c1,,CN1CCCC1=O,O,,,val
US20150094297A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.NC(=O)C1(c2ccc(Cl)cc2)CCOC1>>NC(=S)C1(c2ccc(Cl)cc2)CCOC1,,C1CCOC1,,,,val
US06140351,CCOC(OCC)OCC.COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CCl)c1Cl.NCCN>>COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN2C=NCC2)c1Cl,,CC(=O)O,CN(C)C=O,O,,val
US20080255105A1,Nc1ccc(CN2CCS(=O)(=O)CC2)cc1.O=C(O)c1ccc(-c2cc(NC(=O)C3CCCCC3)ccc2Cl)cc1>>O=C(Nc1ccc(CN2CCS(=O)(=O)CC2)cc1)c1ccc(-c2cc(NC(=O)C3CCCCC3)ccc2Cl)cc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030176454A1,O=C(NCc1cccc(Nc2nccc3c(-c4ccccc4)cccc23)c1)OCc1ccccc1>>NCc1cccc(Nc2nccc3c(-c4ccccc4)cccc23)c1,[Pd],C1CCOC1,,[H][H],,val
US06677473B1,O=C(COc1c(I)cc(C(=O)c2cc(I)c(OCC(=O)OCc3ccccc3)c(I)c2)cc1I)OCc1ccccc1>>O=C(O)COc1c(I)cc(C(=O)c2cc(I)c(OCC(=O)O)c(I)c2)cc1I,,C1CCOC1,,Cl,[Li+].[OH-],val
US20040006106A1,ClCC1CO1.Oc1cccc2[nH]ccc12>>c1cc(OCC2CO2)c2cc[nH]c2c1,,CS(C)=O,,[K+].[OH-],,val
US20050113414A1,CC(C)(C)OC(=O)N1CCC(N)CC1.O=C=Nc1ccc2ccccc2c1>>CC(C)(C)OC(=O)N1CCC(NC(=O)Nc2ccc3ccccc3c2)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US20110144068A1,COP([O-])OC.N#Cc1cccc(C=O)c1>>COP(=O)(OC)C(O)c1cccc(C#N)c1,,CCOC(C)=O,,CCN(CC)CC,,val
US20090258817A1,CCOC(=O)CCCCCCCBr.COc1ccccc1S>>COc1ccccc1SCCCCCCCC(=O)O,,CCO,,[K+].[OH-],,val
US06166006,CCOC(=O)CCCOc1ccc(N)cc1C(=O)OC.ClCCOCCCl>>CCOC(=O)CCCOc1ccc(N2CCOCC2)cc1C(=O)OC,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20100004222A1,CC(=O)c1cnc2cc(NC(=O)c3ccc(/C=C/C(F)(F)F)cc3C)cnc2c1.[Li]C>>Cc1cc(/C=C/C(F)(F)F)ccc1C(=O)Nc1cnc2cc(C(C)(C)O)cnc2c1,,C1CCOC1,,,,val
US20160214977A1,CCn1c2ccccc2c2cc(-c3nc4cc(C(=O)O)ccc4n3CCOC)ccc21.NN.O=C(n1ccnc1)n1ccnc1>>CCn1c2ccccc2c2cc(-c3nc4cc(-c5n[nH]c(=O)o5)ccc4n3CCOC)ccc21,CN(C)c1ccncc1,,,C1CCOC1,O,val
US20150299161A1,CCOC(=O)CCSc1c(F)cccc1-c1ccc(OCC)c(F)c1F>>CCOc1ccc2c(sc3c(F)cccc32)c1F,,C1CCOC1,,O,CC(C)(C)[O-].[K+],val
US04461896,CC(SC(=O)c1ccccc1)C(=O)Cl.O=C(O)C1CCc2ccccc2N1>>CC(SC(=O)c1ccccc1)C(=O)N1c2ccccc2CCC1C(=O)O,,c1ccncc1,,Cl,Cl,val
US20060247250A1,Nc1cnc(Nc2ccc(C(=O)NCCN3CCCC3)cc2)nc1.O=C(Cl)c1c(Cl)cccc1Cl>>O=C(NCCN1CCCC1)c1ccc(Nc2ncc(NC(=O)c3c(Cl)cccc3Cl)cn2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20090264648A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc(-c2cccc(F)c2)[nH]n1>>CC(C)(C)OC(=O)n1nc(N)cc1-c1cccc(F)c1,,ClCCl,,[K+].[OH-],,val
US20090325933A1,COC(=O)c1sccc1N.O=C(Cl)c1ccc(-c2ccccc2)cc1>>COC(=O)c1sccc1NC(=O)c1ccc(-c2ccccc2)cc1,,ClCCl,,CCN(CC)CC,O,val
US20120115864A1,CCCn1c(Cl)nc2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O.CI>>CCCn1c(Cl)nc2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)n(C)c2c1=O,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20060014822A1,CCOC(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)cc1[N+](=O)[O-]>>CCOC(=O)Nc1ccc(N)cc1[N+](=O)[O-],,COCCOC,,NN,O,val
US20110082130A1,CCCC[Sn](CCCC)(CCCC)c1cccnn1.O=C(CN1CCc2cc(Br)ccc2C1)N1CCN(C2CCC2)CC1>>O=C(CN1CCc2cc(-c3cccnn3)ccc2C1)N1CCN(C2CCC2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,Cc1ccccc1,,val
US20120202834A1,Cc1cc(Br)cnc1Cl.FC(F)(F)c1cn[nH]c1>>Cc1cc(Br)cnc1-n1cc(C(F)(F)F)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100130546A1,CNC.O=C(NCCCOc1ccc(F)cc1[N+](=O)[O-])Oc1ccccc1>>CN(C)C(=O)NCCCOc1ccc(F)cc1[N+](=O)[O-],,O,,CN(C)C=O,,val
US20090298878A1,CC(C)C[C@@H](C(=O)N1CCC(=NO)CC1)N(C)C(=O)OC(C)(C)C.Clc1cccc(CBr)c1>>CC(C)C[C@@H](C(=O)N1CCC(=NOCc2cccc(Cl)c2)CC1)N(C)C(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20040254158A1,CC(C)(C)OC(=O)NC1(c2ccc(I)cc2)CC1.CI>>CN(C(=O)OC(C)(C)C)C1(c2ccc(I)cc2)CC1,O,C1CCOC1,,CCOC(C)=O,[H-].[Na+],val
US20100167931A1,COC(=O)c1cnn2c(NC(C)C)c(-n3nc(C)cc3C)c(Cl)nc12>>Cc1cc(C)n(-c2c(Cl)nc3c(C(=O)O)cnn3c2NC(C)C)n1,,C1COCCO1,,Cl,[K+].[OH-],val
US20100160335A1,CC(C)[Si](Oc1cccc(F)c1F)(C(C)C)C(C)C.O=C=O>>CC(C)[Si](Oc1ccc(C(=O)O)c(F)c1F)(C(C)C)C(C)C,,C1CCOC1,,Cl,[Li]CCCC,val
US20040214837A1,CCO.Clc1ccc(-c2c3ncnc(Cl)c3nn2-c2ccccc2Cl)cc1>>CCOc1ncnc2c(-c3ccc(Cl)cc3)n(-c3ccccc3Cl)nc12,,C1CCOC1,,[H-].[Na+],,val
US20130158059A1,Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-],,COC(C)(C)C,,,,val
US20010027196A1,N#Cc1c(OS(=O)(=O)C(F)(F)F)cc(N)nc1-c1ccco1.NCc1ccccc1>>N#Cc1c(NCc2ccccc2)cc(N)nc1-c1ccco1,,COCCOC,,,,val
US20040087626A1,Cn1c(Nc2cccc(C(C)(C)C)c2)nc2cc(OC3(C(=O)O)C=CC=CN3)ccc21.NCCC1CCCCN1>>Cn1c(Nc2cccc(C(C)(C)C)c2)nc2cc(OC3(C4CCNC(CCNC=O)C4)C=CC=CN3)ccc21,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130336965A1,CCI.C[C@H]1CC(c2ccncc2[N+](=O)[O-])=C[C@@H](NC(=O)OC(C)(C)C)[C@H]1O>>CCO[C@@H]1[C@H](NC(=O)OC(C)(C)C)C=C(c2ccncc2[N+](=O)[O-])C[C@@H]1C,O=[Ag],C1CCOC1,,,,val
US20120142717A1,COc1ncc(Cc2c[nH]c(=S)[nH]c2=O)cn1.FC(F)(F)c1cc(Oc2ccc(CCI)cc2)ccc1Cl>>COc1ncc(Cc2c[nH]c(SCCc3ccc(Oc4ccc(Cl)c(C(F)(F)F)c4)cc3)nc2=O)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080293753A1,COC(=O)[C@@H]1CC[C@H](c2cccc(OCc3ccccc3)c2)N1C(=O)OC(C)(C)C.N#CCBr>>COC(=O)[C@]1(CC#N)CC[C@H](c2cccc(OCc3ccccc3)c2)N1C(=O)OC(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05028629,CCCCCCc1ccc(SC)c(C=CC(=O)O)c1.O=C(Cl)C(=O)Cl>>CCCCCCc1ccc(SC)c(C=CC(=O)Cl)c1,,ClCCl,,CN(C)C=O,,val
US20060229336A1,NC1CC2CCC(C1)N2Cc1ccccc1.O=[N+]([O-])c1ccccc1F>>O=[N+]([O-])c1ccccc1NC1CC2CCC(C1)N2Cc1ccccc1,,CCOC(C)=O,CN1CCCC1=O,CCN(C(C)C)C(C)C,,val
US20120258949A1,COC(=O)/C=C/c1cc(F)c2c(c1)C(=O)CC1(CCN(C(=O)OC(C)(C)C)CC1)O2>>COC(=O)/C=C/c1cc(F)c2c(c1)C(=O)CC1(CCNCC1)O2,,C1COCCO1,ClCCl,Cl,,val
US20090156612A1,CCOC(=O)c1ncn([C@H]2CCCC[C@@H]2O)c1-c1ccccc1>>CCOC(=O)c1ncn(C2CCCCC2=O)c1-c1ccccc1,,CS(C)=O,,CCN(CC)CC,,val
US20060194836A1,Nc1ccc(Cl)cc1.O=C(Cl)c1cccnc1Cl>>O=C(Nc1ccc(Cl)cc1)c1cccnc1Cl,,C1CCOC1,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2ccc(O[C@H]3CCC[C@@H]3c3ccnn3C)c(C#N)c2)c(OC)c1>>Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(S(=O)(=O)Nc2ccncn2)cc1C#N,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20100004221A1,CC(C)(C)OC(=O)NNC(=O)c1ccc(Br)cc1Cl.OB(O)c1ccc(F)cc1>>CC(C)(C)OC(=O)NNC(=O)c1ccc(-c2ccc(F)cc2)cc1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20140200216A1,CC(C)(C)OC(=O)N[C@H]1C[C@@H](C(F)(F)F)CN(c2ccncc2[N+](=O)[O-])C1>>CC(C)(C)OC(=O)N[C@H]1C[C@@H](C(F)(F)F)CN(c2ccncc2N)C1,[Fe],O,,CC(=O)O,,val
US06300353B1,C[C@@H](c1nc(-c2ccc(C#N)cc2)cs1)[C@](O)(Cn1cncn1)c1cc(F)ccc1F.Cc1cc(C(C)(Br)OC(=O)CN)cc(C)c1C(=O)OC(C)(C)C>>C[C@@H](c1nc(-c2ccc(C#N)cc2)cs1)[C@](O)(Cn1c[nH+]cn1)c1cc(F)ccc1F.[Br-],,CC#N,,,,val
US04771054,CCOC(=O)c1cn(C2CC2)c2c(Cl)c(F)c(F)cc2c1=O>>O=C(O)c1cn(C2CC2)c2c(Cl)c(F)c(F)cc2c1=O,,C1CCOC1,,Cl,,val
US06180650B2,CS(=O)(=O)Cl.Nc1ccc(Oc2ccc(C(Cc3ccncc3)c3ccc(OC(F)F)c(OC(F)F)c3)cn2)cc1>>CS(=O)(=O)Nc1ccc(Oc2ccc(C(Cc3ccncc3)c3ccc(OC(F)F)c(OC(F)F)c3)cn2)cc1,,ClCCl,,CCN(CC)CC,,val
US05246931,CC(C)(C)[Si](C)(C)OC[C@H]1[C@H](CO[Si](C)(C)C(C)(C)C)C12CO2>>CC(C)(C)[Si](C)(C)OC[C@@H]1C(=O)C[C@H]1CO[Si](C)(C)C(C)(C)C,,ClCCl,,[I-].[Li+],,val
US20130296344A1,CI.COc1cc(C2C(C#N)=C(N)Oc3c2cc(O)c2ccccc32)cc(Br)c1OC>>COc1cc(C2C(C#N)=C(N)Oc3c2cc(OC)c2ccccc32)cc(Br)c1OC,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20060052379A1,CCn1nc(-c2ccccc2)c(C(C)=O)c([N+](=O)[O-])c1=O.Cc1cccc(N)c1>>CCn1nc(-c2ccccc2)c(C(C)=O)c(Nc2cccc(C)c2)c1=O,,CCO,,,,val
US20040077877A1,Fc1ccc(-c2nn(C3CCCCO3)c3ccc(Br)cc23)cc1.O=CCc1ccccc1>>OC(Cc1ccccc1)c1ccc2c(c1)c(-c1ccc(F)cc1)nn2C1CCCCO1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20120165369A1,FC(F)(F)c1ccccc1Sc1cnc2ccccc2c1.ICCCCCc1ccccc1>>FC(F)(F)c1ccccc1Sc1cc2ccccc2[n+](CCCCCc2ccccc2)c1.[I-],,O=S1(=O)CCCC1,,CCOCC,,val
US06504034B2,CC(C)(C)OC(=O)Oc1cc2c(C#CC(O)c3cccn3C(=O)OC(C)(C)C)c(F)ccc2n1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)Oc1cc2c(C#CC(=O)c3cccn3C(=O)OC(C)(C)C)c(F)ccc2n1C(=O)O,O=[Mn]=O,ClCCl,,,,val
US06114334,O=CNNc1ccccc1>>CNNc1ccccc1,,C1CCOC1,CCOCC,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150291593A1,CCOC(=O)C(N)C(OCC)n1ccc(C)c1C(=O)OC>>CCOC(=O)C1NC(=O)c2c(C)ccn2C1OCC,,Cc1ccccc1,,,,val
US04962103,CC(=O)S[C@H]1C[C@@H](CCC(=O)O)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1.O=[N+]([O-])c1ccc(CBr)cc1>>CC(=O)S[C@H]1C[C@@H](CCC(=O)OCc2ccc([N+](=O)[O-])cc2)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1,,CN(C)C=O,,CCN(CC)CC,O,val
US20120316188A1,COc1ccc(Cn2cc(-c3nc(Nc4ccccn4)ns3)cn2)cc1>>c1ccc(Nc2nsc(-c3cn[nH]c3)n2)nc1,,O=C(O)C(F)(F)F,,[Na+].[OH-],,val
US20150018345A1,C=C[C@@H](N[S@@](=O)C(C)(C)C)c1cc(C)cc(C(F)(F)F)c1.CI>>C=C[C@H](c1cc(C)cc(C(F)(F)F)c1)N(C)[S@@](=O)C(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20140228367A1,CI.CNC(=O)c1cc(Oc2ccc(NC(=O)c3nc(S(C)(=O)=O)[nH]c3-c3ccc(F)cc3)cc2)ccn1>>CNC(=O)c1cc(Oc2ccc(NC(=O)c3nc(S(C)(=O)=O)n(C)c3-c3ccc(F)cc3)cc2)ccn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04556660,Fc1ccc(Cn2c(NC3CCN(CCN=C=S)CC3)nc3ccccc32)cc1.NCc1cccnc1>>Fc1ccc(Cn2c(NC3CCN(CCNC(=S)NCc4cccnc4)CC3)nc3ccccc32)cc1,,C1CCOC1,,,,val
US04363917,CO.Cc1ccc(N=C(O)c2c(C(O)=S)cc([N+](=O)[O-])cc2-c2ccccc2)cc1>>COc1cc(C(O)=S)c(C(O)=Nc2ccc(C)cc2)c(-c2ccccc2)c1,,CS(C)=O,,Cl,C[O-].[Na+],val
US20140142102A1,CC(C)N=C=O.O=C(OCc1ccccc1)N1CCNCC1>>CC(C)NC(=O)N1CCN(C(=O)OCc2ccccc2)CC1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US04927822,CCOC(=O)C1SC(c2ccccc2)=NN1C(=O)CCSC(C)=O>>O=C(O)C1SC(c2ccccc2)=NN1C(=O)CCS,,CO,O,[K+].[OH-],,val
US20120122764A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)O.CNC>>CN(C)C(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)OC(C)(C)C,,CN(C)C=O,ClCCl,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140162971A1,Cc1ccc(S(=O)(=O)n2ccc3c(-c4cc(S(C)(=O)=O)ccc4F)cn(C)c(=O)c32)cc1.OC1CCC1>>Cn1cc(-c2cc(S(C)(=O)=O)ccc2OC2CCC2)c2cc[nH]c2c1=O,,C1CCOC1,,[H-].[Na+],,val
US06020329,CC(=O)OC(C)Br.CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C([C@@H]3CCCO3)CS[C@H]12)c1csc(N)n1>>CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)OC(C)OC(C)=O)=C([C@@H]3CCCO3)CS[C@H]12)c1csc(N)n1,,CCOC(C)=O,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],,val
US20090281140A1,C=CCCCCN(C)C(=O)C1CC(Oc2cc(-c3cccc(C)n3)nc3c(C)c(OC)ccc23)CC1C(=O)NC1(C(=O)OCC)CC1C=C>>CCOC(=O)C12CC1C=CCCCCN(C)C(=O)C1CC(Oc3cc(-c4cccc(C)n4)nc4c(C)c(OC)ccc34)CC1C(=O)N2,,ClCCCl,,,,val
US20090137581A1,CC(c1cc2c(Cl)cccc2nc1-c1ccccn1)N1C(=O)c2ccccc2C1=O>>CC(N)c1cc2c(Cl)cccc2nc1-c1ccccn1,,CCO,,NN,O,val
US20080262021A1,C1CNCCN1.Fc1cccc(-c2ccc3ncc4ncn(-c5ccccc5)c4c3c2)c1>>c1ccc(-n2cnc3cnc4ccc(-c5cccc(N6CCNCC6)c5)cc4c32)cc1,,CN1CCCC1=O,,,,val
US20110052674A1,CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1,,ClCCl,,CCN(CC)CC,,val
US05710170,COc1ccc(C=O)cc1OC1CCCC1.O=P(Oc1ccccc1)(Oc1ccccc1)C(Cl)c1ccncc1>>COc1ccc(C#Cc2ccncc2)cc1OC1CCCC1,,C1COCCO1,O,CC(C)(C)[O-].[K+],,val
US20120040020A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ncc(Br)nc1-c1nc2ccccc2[nH]1>>Cc1ccc(S(=O)(=O)n2c(-c3nc(Br)cnc3N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nc3ccccc32)cc1,CN(C)c1ccncc1,ClCCl,,[H-].[Na+],,val
US20150104384A1,N#Cc1ccc(S(=O)(=O)N2CCN(CC(F)(F)F)CC2)cc1>>NCc1ccc(S(=O)(=O)N2CCN(CC(F)(F)F)CC2)cc1,[Ni],N,,[H][H],,val
US20100168167A1,CNc1ccccc1N.O=C(O)CCl>>Cn1c(CCl)nc2ccccc21,,Cl,,N,,val
US20080312317A1,C=CC[C@H](NC(=O)OC(C)(C)C)/C(C)=C/CO.O=C(OC(=O)c1ccccc1)c1ccccc1>>C=CC[C@H](NC(=O)OC(C)(C)C)/C(C)=C/COC(=O)c1ccccc1,CN(C)c1ccncc1,ClCCl,,O,c1ccncc1,val
US20120053180A1,BrCC1CCCCC1.CS(=O)(=O)c1ccc(CN2CCNCC2)cc1>>CS(=O)(=O)c1ccc(CN2CCN(CC3CCCCC3)CC2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20020132796A1,C#C[Si](C)(C)C.CC(C)c1cc(OS(=O)(=O)C(F)(F)F)ccc1C(C)(C)O[SiH2]C(C)(C)C>>CC(C)c1cc(C#C[Si](C)(C)C)ccc1C(C)(C)O[SiH2]C(C)(C)C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCN(CC)CC,CN(C)C=O,,,val
US20090286791A1,CCOC(=O)c1cn(Cc2ccccn2)nc1C(F)(F)F>>O=C(O)c1cn(Cc2ccccn2)nc1C(F)(F)F,,C1CCOC1,,CCO,[Na+].[OH-],val
US20140057893A1,C1CNC1.COCc1noc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)O)c(F)c3)CC2)n1>>COCc1noc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)c(F)c3)CC2)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060235031A1,COC(=O)[C@@H]1CC[C@@H](C(=O)NCc2nccnc2Cl)CC1>>COC(=O)[C@@H]1CC[C@@H](c2ncc3c(Cl)nccn23)CC1,,CC#N,,CN(C)C=O,,val
US20080093984A1,NNc1ccc([N+](=O)[O-])cc1.O=C(Cc1ccccc1)C(=O)c1ccccc1>>O=[N+]([O-])c1ccc(-n2nc(-c3ccccc3)cc2-c2ccccc2)cc1,,Cc1ccccc1,,,,val
US20110098302A1,CCOC(=O)Cc1cccc(Oc2ccc(Br)cc2CBr)c1.O=C1CCCN1>>CCOC(=O)Cc1cccc(Oc2ccc(Br)cc2CN2CCCC2=O)c1,,C1COCCO1,,[H-].[Na+],,val
US20110281888A1,Brc1cnc2[nH]ccc2c1.COc1ccc(F)c(Cl)c1C=O>>COc1ccc(F)c(Cl)c1C(O)c1c[nH]c2ncc(Br)cc12,,CO,,[K+].[OH-],,val
US20130172353A1,COc1ccc(CNc2nsc(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2C#N)c(OC)c1>>Cc1ccc(F)c(NC(=O)Nc2ccc(-c3snc(N)c3C#N)cc2)c1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20070179060A1,COc1c(C)cc(F)cc1F.II>>COc1c(C)cc(F)c(I)c1F,,C1CCOC1,CCOC(C)=O,CC(C)[N-]C(C)C.[Li+],,val
US20110065702A1,CC(=O)OC(C)=O.Nc1ccc2c(c1)NC(=O)C2>>CC(=O)Nc1ccc2c(c1)NC(=O)C2,,C1CCOC1,,,,val
US06217793B1,CCCCCCCC[C@H](C)C(=O)Oc1ccc(O)cc1.O=C(O)c1ccc(OCc2ccccc2)cc1>>CCCCCCCC[C@H](C)C(=O)Oc1ccc(OC(=O)c2ccc(OCc3ccccc3)cc2)cc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100305133A1,CCOC(=O)CNC(=O)c1c(O)c(-c2cccs2)cc2nccnc12>>O=C(O)CNC(=O)c1c(O)c(-c2cccs2)cc2nccnc12,,CCO,,[Na+].[OH-],,val
US20060235030A1,CC(C)NCCCN.CCCNC(=O)c1ccc(C)c(-c2nc(S(C)=O)nc3c2CNC(=O)N3c2c(F)cccc2F)c1>>CCCNC(=O)c1ccc(C)c(-c2nc(NCCCNC(C)C)nc3c2CNC(=O)N3c2c(F)cccc2F)c1,,ClCCl,,,,val
US20050004129A1,CO.Clc1ccc2c(n1)CCN(Cc1ccccc1)C2>>COc1ccc2c(n1)CCN(Cc1ccccc1)C2,,CN(C)C=O,,[Na],,val
US05240938,COC(=O)C(Oc1ccccc1)c1ccc(C)cc1.O=C1CCC(=O)N1Br>>COC(=O)C(Oc1ccccc1)c1ccc(CBr)cc1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20100009975A1,CN1CCCC1CCN1CCSc2cc([N+](=O)[O-])ccc21>>CN1CCCC1CCN1CCSc2cc(N)ccc21,[Ni],CO,,NN,O,val
US20100029611A1,C=C(B(O)O)c1ccccc1.Cc1nc2ccc(Cl)nc2s1>>C=C(c1ccccc1)c1ccc2nc(C)sc2n1,,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20110257151A1,CC1(C)Cc2cc(C(=O)NS(C)(=O)=O)ccc2NC1c1cccc([N+](=O)[O-])c1>>CC1(C)Cc2cc(C(=O)NS(C)(=O)=O)ccc2NC1c1cccc(N)c1,[Fe],CCO,Cl,,,val
US20140024650A1,CCOC(=O)C1COCCC1NCc1ccccc1>>CCOC(=O)C1COCCC1N,,CCO,,,,val
US20110015157A1,CC(=O)C[C@]1(c2ccccc2)CCN([C@@H](C)c2ccc(OC(F)F)cc2)C(=O)O1.C[Mg]Br>>C[C@@H](c1ccc(OC(F)F)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O,,C1CCOC1,,,,val
US20050215578A1,CSc1nsc(Cl)n1.OCc1cnccc1Cl>>CSc1nsc(OCc2ccc(Cl)nc2)n1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20050004120A1,CC(C)c1cnc(NC(=O)Cc2csc(NC(=O)OC(C)(C)C)n2)s1>>CC(C)c1cnc(NC(=O)Cc2csc(N)n2)s1,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20040048858A1,CI.COc1cc(/C=C/C(=O)c2ccc(NS(C)(=O)=O)cc2)cc(-c2cccs2)c1OC>>COc1cc(/C=C/C(=O)c2ccc(N(C)S(C)(=O)=O)cc2)cc(-c2cccs2)c1OC,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100273781A1,CC(C)(C)OC(=O)N1CCN(c2ccccc2C(=O)Nc2ccccc2)CC1.O=C(O)C(F)(F)F>>O=C(Nc1ccccc1)c1ccccc1N1CCNCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20150374849A1,C=CCN(CCCCC(=O)OCCc1c2ccccc2cc2ccccc12)C(=O)OC(C)(C)C>>C=CCNCCCCC(=O)OCCc1c2ccccc2cc2ccccc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090163508A1,CC(C)(C)OC(=O)N1CCN(c2cc(-c3cccc(F)c3)ncn2)CC1>>Fc1cccc(-c2cc(N3CCNCC3)ncn2)c1,,CCOC(C)=O,,Cl,,val
US20160002205A1,BrCc1ccccc1.C[C@H]1CN(C(=O)OC(C)(C)C)CCN1>>C[C@H]1CN(C(=O)OC(C)(C)C)CCN1Cc1ccccc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120289551A1,C[Si](C)(C)C#Cc1ccnc(N)c1.O=C=NC(=O)c1ccccc1>>C#Cc1ccnc(NC(N)=O)c1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20070197542A1,CS(=O)(=O)N1CCN(c2ncc(I)cn2)CC1.OCc1ccccc1>>CS(=O)(=O)N1CCN(c2ncc(OCc3ccccc3)cn2)CC1,[Cu]I,ClCCl,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US04634701,NCCCCl.Sc1nc2ccccc2o1>>NCCCSc1nc2ccccc2o1,,CCO,O,[Na+].[OH-],,val
US20070185089A1,CC(C)(C)OC(=O)N1CCc2ccc(-c3ccc(O)cc3)cc2CC1.CNC(=O)c1ccc(Cl)nc1>>CNC(=O)c1ccc(Oc2ccc(-c3ccc4c(c3)CCN(C(=O)OC(C)(C)C)CC4)cc2)nc1,,CS(C)=O,,[H-].[Na+],,val
US20020161006A1,BrCc1ccccc1COCCCNC(c1ccccc1)(c1ccccc1)c1ccccc1.COC(=O)CC(C)=O>>COC(=O)CC(=O)CCc1ccccc1COCCCNC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,[Li]CCCC,[H-].[Na+],val
US20120010203A1,CCNCC.Cc1cc(C(=O)O)nn2c(N)nnc12>>CCNC(=O)c1cc(C)c2nnc(N)n2n1,,CN(C)C=O,,Cl,,val
US06124323,CCOC(=O)C(=O)OCC.Cc1cc(OCCOCc2ccccc2)ccc1[N+](=O)[O-]>>CCOC(=O)C(=O)Cc1cc(OCCOCc2ccccc2)ccc1[N+](=O)[O-],,C1CCOC1,CCO,[H][H],[H-].[Na+],val
US20140371278A1,C=COCCON.COC(=O)c1cc2scnc2c(F)c1Nc1ccc(I)cc1F>>C=COCCONC(=O)c1cc2scnc2c(F)c1Nc1ccc(I)cc1F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20130109789A1,CCOC(=O)C(C(=O)OCC)C(C)C.COCCl>>CCOC(=O)C(COC)(C(=O)OCC)C(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20080167361A1,COC(=O)CBr.Cc1cc(Br)ccc1CC#N>>COC(=O)CC(C#N)c1ccc(Br)cc1C,,C1CCOC1,O,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US05206372,CN(C)C=CC=C(C#N)C(=O)N(C)C.Cl>>CN(C)C(=O)c1cccnc1Cl,,ClCCCl,,,,val
US03951989,CCI.CCOC(=O)c1cnc2sc(C)cc2c1O>>CCn1cc(C(=O)O)c(=O)c2cc(C)sc21,,CCO,O,Cl,[K+].[OH-],val
US05869605,CC(=O)OC(C)=O.OCC1c2ccccc2-c2c1c1ccccc1c1ccccc21>>CC(=O)OCC1c2ccccc2-c2c1c1ccccc1c1ccccc21,O=S(=O)(O)O,,,,,val
US03962257,CN1CCCC(CC(=O)c2ccccc2Cl)C1.Cl>>CN1CCCC(CC(=O)c2ccccc2Cl)C1.Cl,,CCOCC,,,,val
US20040063707A1,CC(=O)Cl.CC(C)[Si](C(C)C)(C(C)C)n1ccc2cc(N)cnc21>>CC(=O)Nc1cnc2c(ccn2[Si](C(C)C)(C(C)C)C(C)C)c1,CN(C)c1ccncc1,c1ccncc1,,CCOC(C)=O,[Cl-].[NH4+],val
US20040132727A1,COc1cc2nccc(Oc3ccc(NC(=O)COc4ccc(F)cc4)cc3)c2cc1OC>>COc1cc2nccc(Oc3ccc(NCCOc4ccc(F)cc4)cc3)c2cc1OC,,C1CCOC1,,Cl,[Na+].[OH-],val
US06018046,O=C1CCn2c3ccccc3c3cccc1c32.O=Cc1ccccc1>>O=C(c1ccccc1)c1cn2c3ccccc3c3cccc(c1=O)c32,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
USRE039112E1,Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCC3)nc21.O=S(=O)(O)O>>Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(OS(=O)(=O)O)CCCC3)nc21,,CO,,,,val
US20060074084A1,CCOC(=O)c1[nH]c2ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc2c1Br.OB(O)c1cccc(F)c1>>CCOC(=O)c1[nH]c2ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc2c1-c1cccc(F)c1,,CCCCCC,CCOC(C)=O,,,val
US20100120858A1,CC(C)(C)OC(=O)N1CCC[C@H](COc2ccccc2OCc2ccccc2)C1>>CC(C)(C)OC(=O)N1CCC[C@H](COc2ccccc2O)C1,[Pd],CCO,,,,val
US20040063705A1,COc1cc(N)cc(OC)c1OCCN1CCN(C)CC1.Cc1cccc(C)c1N(c1ccnc(Cl)n1)c1nc2ccccc2[nH]1>>COc1cc(Nc2nccc(N(c3nc4ccccc4[nH]3)c3c(C)cccc3C)n2)cc(OC)c1OCCN1CCN(C)CC1,,CC(=O)O,,[Na+].[OH-],,val
US04005217,CCCCc1ccc(NC(=S)NC(=O)OC)c(N)c1.O=CO>>CCCCc1ccc(NC(=S)NC(=O)OC)c(NC=O)c1,,O,,,,val
US20100261755A1,COC(=O)C1CCNC(Cc2cc(C(C)(C)C)cc(C(C)(C)C)c2)C1.COC(=O)Cl>>COC(=O)C1CCN(C(=O)OC)C(Cc2cc(C(C)(C)C)cc(C(C)(C)C)c2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140315917A1,O=[N+]([O-])c1ccc(O)c(Cl)c1F>>Nc1ccc(O)c(Cl)c1F,[Zn],C1CCOC1,,CO,[Cl-].[NH4+],val
US20110269804A1,Cc1cc(C#N)ccc1Br>>Cc1cc(CN)ccc1Br,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100222345A1,O=Cc1ccc(O)cc1Cl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=Cc1ccc(OS(=O)(=O)C(F)(F)F)cc1Cl,,ClCCl,,c1ccncc1,,val
US20040266789A1,CS(=O)(=O)Cl.OCc1ccc(-c2nc(-c3ccccc3)cc(-c3ccccc3)n2)cc1>>CS(=O)(=O)OCc1ccc(-c2nc(-c3ccccc3)cc(-c3ccccc3)n2)cc1,,ClCCl,,CCN(CC)CC,,val
US20090054398A1,CC(C)(C)OC(=O)NC1C(=O)Nc2ccccc2OC1c1ccccc1.Cl>>[Cl-].[NH3+]C1C(=O)Nc2ccccc2OC1c1ccccc1,,C1COCCO1,,CCOCC,,val
US20150210690A1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.N[C@H](C[C@@H](Cc1ccc(-c2cc(Cl)ccc2F)cc1)NC(=O)c1c[nH]nn1)C(=O)O>>NCC(=O)N[C@H](C[C@@H](Cc1ccc(-c2cc(Cl)ccc2F)cc1)NC(=O)c1c[nH]nn1)C(=O)O,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20050209460A1,Cc1cccc(N)c1.NS(=O)(=O)c1cnccc1Cl>>Cc1cccc(Nc2ccncc2S(N)(=O)=O)c1.Cl,,CCCCO,,,,val
US20100197683A1,Nc1nc[nH]n1.O=C1CCC2(CC1)OCCO2>>c1nnc(NC2CCC3(CC2)OCCO3)[nH]1,,CC(=O)O,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20050119320A1,CC(=O)Nc1nc(C)c(-c2ccc(N)cc2)s1.O=C1CCC(=O)N1Br>>CC(=O)Nc1nc(C)c(-c2ccc(N)c(Br)c2)s1,,CS(C)=O,O,,,val
US05051412,Cc1cc(=O)[nH]cc1[N+](=O)[O-].O=S(Cl)Cl>>Cc1cc(Cl)ncc1[N+](=O)[O-],CN(C)C=O,,,,,val
US06582351B1,CC(=O)OC(C)=O.CC(C)(CO)Nc1ncc(C(F)(F)F)cc1[N+](=O)[O-]>>CC(=O)OCC(C)(C)Nc1ncc(C(F)(F)F)cc1[N+](=O)[O-],,c1ccncc1,,,,val
US06329381B1,COc1cccc(CCl)c1.Nc1nc(S)nc2c1nc(O)n2Cc1ccccc1>>COc1cccc(CSc2nc(N)c3nc(O)n(Cc4ccccc4)c3n2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120041012A1,CC(C)(C)OC(=O)N1CCC2(CC1)CNC(=O)C2.COC(=O)CBr>>COC(=O)CN1CC2(CCN(C(=O)OC(C)(C)C)CC2)CC1=O,,CN(C)C=O,,[H-].[Na+],,val
US20150018343A1,CCOP(=O)(Cc1ccccc1C(=O)OC)OCC.CN1CCC(=O)CC1>>COC(=O)c1ccccc1C=C1CCN(C)CC1,,C1CCOC1,,C1COCCOCCOCCOCCO1,[H-].[Na+],val
US20110101854A1,CCSC(=Nc1ccccc1)C(C)C.NNC(=O)c1ccc2ccccc2c1>>CC(C)c1nnc(-c2ccc3ccccc3c2)n1-c1ccccc1,,Cc1ccccc1,,CCCCO,,val
US20160207922A1,Cc1ccc(S(=O)(=O)OCC2OCCc3c2ccc2c3COC2=O)cc1.N#Cc1ccc(N2CCC3(CCNCC3)C2)nc1>>N#Cc1ccc(N2CCC3(CCN(CC4OCCc5c4ccc4c5COC4=O)CC3)C2)nc1,,CC#N,,,,val
US06335360B1,CC[C@H](NC(=O)OC(C)(C)C)C(=O)O.COC(=O)C1Cc2cc(OC)ccc2N1>>CC[C@H](NC(=O)OC(C)(C)C)C(=O)N1c2ccc(OC)cc2CC1C(=O)OC,,ClCCl,,CC(C)N=C=NC(C)C,,val
US05110925,CC1CC(=O)NN=C1c1ccc(N)cc1.O=C1CCC(=O)C1>>CC1CC(=O)NN=C1c1ccc(NC2=CC(=O)CC2)cc1,,CC(=O)O,CCO,,,val
US05981533,CN(C)C(OCc1ccccc1)OCc1ccccc1.N#Cc1c(-c2cccc([N+](=O)[O-])c2)n[nH]c1N>>CN(C)C=Nc1[nH]nc(-c2cccc([N+](=O)[O-])c2)c1C#N,,Cc1ccccc1,,,,val
US20020013348A1,CC(C)(O)CC1CCN(C(=O)OC(C)(C)C)CC1.CI>>COC(C)(C)CC1CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20160229816A1,CCCC(=O)OC(C)I.Cc1cc(-c2nccc(C(F)(F)F)n2)cc(-c2nn[nH]c2C#N)c1>>CCCC(=O)OC(C)n1nc(C#N)c(-c2cc(C)cc(-c3nccc(C(F)(F)F)n3)c2)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04670562,NO.O=C1c2cc(Cl)ccc2CN2C(=O)CCC12>>O=C1c2cc(Cl)ccc2CN2CCC(=NO)C12,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20130123268A1,COC1(c2ncccc2C)CC2CCC(C1)N2C(=O)OC(C)(C)C.Cl>>COC1(c2ncccc2C)CC2CCC(C1)N2.Cl,,C1COCCO1,Cl,ClCCl,,val
US20030199491A1,COc1ccc2[nH]c(C)cc2c1F>>Cc1cc2c(F)c(O)ccc2[nH]1,,ClCCl,,BrB(Br)Br,,val
US20050165001A1,CC(C)(C)OC(=O)N1CCN(c2c(F)ccc3c2CNC(=O)N3Cc2ccccc2)CC1>>O=C1NCc2c(ccc(F)c2N2CCNCC2)N1Cc1ccccc1,,CCO,Cl,CCOCC,,val
US20080039509A1,Nc1ccc(F)cc1N.O=C(C=Cc1ccccc1)NCc1ccc(C(=O)O)cc1>>Nc1cc(F)ccc1NC(=O)c1ccc(CNC(=O)C=Cc2ccccc2)cc1,,C1CCOC1,,O=C(O)C(F)(F)F,,val
US20120107258A1,CCCCC=O.O=CC=Cc1ccccc1>>CCCC(C=O)=CC=Cc1ccccc1,,CO,,[Na+].[OH-],,val
US20020037885A1,Brc1ccccc1-c1noc2c1CCCC2.CCOCC>>O=Cc1ccccc1-c1noc2c1CCCC2,,CCCCCC,,[Li]CCCC,,val
US04278671,CCOC(=O)C(=O)c1csc(N)n1.CON>>CCOC(=O)C(=NOC)c1csc(N)n1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20100249124A1,COC(=O)c1ccc(Cl)nc1.Cc1cc(C(O)(C(C)c2ccc(O)cc2Cl)C(F)(F)F)cc(C)c1C#N>>COC(=O)c1ccc(Oc2ccc(C(C)C(O)(c3cc(C)c(C#N)c(C)c3)C(F)(F)F)c(Cl)c2)nc1,,CC(=O)N(C)C,CCOC(C)=O,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20060276508A1,COc1cc(OCC(N)=O)cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)c1.Cl>>COc1cc(OCC(N)=O)cc(C(=O)NC2CCNCC2)c1.Cl,,CCO,,C1COCCO1,,val
US20100298257A1,CC(C)[Si](Cl)(O[Si](Cl)(C(C)C)C(C)C)C(C)C.O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1>>CC(C)[Si]1(C(C)C)OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](O)[C@@H]2O[Si](C(C)C)(C(C)C)O1,,c1ccncc1,,,,val
US20020165282A1,CCCCCCC(=O)NCCc1ccc(NC(C)(C)C(=O)OC(C)(C)C)cc1>>CCCCCCCNCCc1ccc(NC(C)(C)C(=O)O)cc1,,C1CCOC1,,B,Cl,val
US20120071482A1,N[C@H]1CCc2ccccc21.OC[C@H]1C[C@@H](Nc2cc(Cl)ncn2)C[C@@H]1O>>OC[C@H]1C[C@@H](Nc2cc(N[C@H]3CCc4ccccc43)ncn2)C[C@@H]1O,,CCCCO,,,,val
US20060199817A1,NC1CC1.O=C(O)c1ccc(F)c(-c2ccc3c(N4CCOCC4)nncc3c2)c1>>O=C(NC1CC1)c1ccc(F)c(-c2ccc3c(N4CCOCC4)nncc3c2)c1,,C1COCCO1,CCOC(C)=O,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US20100145090A1,COC(=O)[C@H](Cc1c(C)cc(C#N)cc1C)NC(=O)OC(C)(C)C.OO>>Cc1cc(C(N)=O)cc(C)c1C[C@H](NC(=O)OC(C)(C)C)C(=O)O,,O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US08618288B2,Cc1ccc(-c2cc(CO)nc(Cc3ccccc3)n2)cc1>>Cc1ccc(-c2cc(C=O)nc(Cc3ccccc3)n2)cc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US04246292,CC(=O)/C=C/C1=C(C)CCCC1(C)C>>CCCCC1C(C)C(=O)CCC1(C)C,[Pd],,,CO,,val
US20110130453A1,COC(=O)Cc1cccc(Oc2ccc(Br)cc2CN(CCc2ccccc2)C(=O)OC)c1>>COC(=O)N(CCc1ccccc1)Cc1cc(Br)ccc1Oc1cccc(CC(=O)O)c1,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US05021431,NCCCc1c[nH]cn1.O=C(NC(=NCCCOc1ccccc1)Oc1ccccc1)c1ccccc1>>O=C(NC(=NCCCOc1ccccc1)NCCCc1c[nH]cn1)c1ccccc1,,CC#N,,,,val
US20100144722A1,COC(=O)C1(c2ccc(Nc3nc(-c4cnn(C)c4)cc(N4CCOCC4)n3)cc2)CCC1>>Cn1cc(-c2cc(N3CCOCC3)nc(Nc3ccc(C4(C(=O)O)CCC4)cc3)n2)cn1,,CO,,O,[Na+].[OH-],val
US20030087924A1,COC(=O)c1cc(NC(=O)NCc2ccccc2)c(C)s1>>Cc1sc(C(=O)O)cc1NC(=O)NCc1ccccc1,,CO,O,Cl,[K+].[OH-],val
US20090054427A1,C=Cc1cc(C[C@@H]2CS(=O)(=O)C[C@H](NCc3cccc(C(C)(C)C)c3)[C@H]2O)cc(F)c1N>>CCc1cc(C[C@@H]2CS(=O)(=O)C[C@H](NCc3cccc(C(C)(C)C)c3)[C@H]2O)cc(F)c1N,[Pd],CCO,,,,val
US20070173506A1,BrBr.CC(=O)Nc1nc(CCOC(C)=O)cs1>>CC(=O)Nc1nc(CCOC(C)=O)c(Br)s1,,CC(=O)O,,,,val
US20160272651A1,CCOC(=O)CBr.CCc1cc(Br)cc(C)c1N1CCNC1=O>>CCOC(=O)CN1CCN(c2ccc(Br)cc2CC)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US05344843,COC(=O)C(=O)c1ccc(OCCOc2cc3ccccc3c3ccccc23)cc1>>O=C(O)C(=O)c1ccc(OCCOc2cc3ccccc3c3ccccc23)cc1,,C1CCOC1,O,[Na+].[OH-],,val
US20150252044A1,CC(C)(C)N.O=C(O)c1ccc2cncc(-c3ccc(Cl)cc3)c2n1>>CC(C)(C)NC(=O)c1ccc2cncc(-c3ccc(Cl)cc3)c2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110275611A1,CSc1nc(Cl)cc(Cl)n1.FC(F)(F)[C@@H]1CCCN1>>CSc1nc(Cl)cc(N2CCC[C@H]2C(F)(F)F)n1,,C1CCOC1,O,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US05196147,CN(C)c1ccc(C=O)cc1.COC(=O)CC#N>>CN(C)c1ccc(C=C(C#N)C(=O)O)cc1,,CCO,,Cl,[Na+].[OH-],val
US20150299105A1,C=C(C)OC(C)=O.COC[C@@H](N)C(=O)NCc1ccccc1>>COCC(NC(C)=O)C(=O)NCc1ccccc1,,CC(=O)OC(C)C,,,,val
US05237070,CC(=O)OC(C)=O.CC(C)(C)c1cc(Nc2cccc(C(=O)O)c2)cc(C(C)(C)C)c1O>>CC(=O)N(c1cccc(C(=O)O)c1)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,c1ccncc1,O,,,,val
US20110313190A1,O=C(Cl)c1ccccc1.OCCCCC(F)(F)C(F)(F)Br>>CCCCC(F)(F)C(F)(F)Br.O=C(O)c1ccccc1,,O,,C1CCOC1,CCN(CC)CC,val
US04282238,CC(C)CCCC(C)CCCC(C)Br.c1c[nH]cn1>>CC(C)CCCC(C)CCCC(C)n1ccnc1,,C1CCOC1,,,,val
US20060084651A1,CCn1c(-c2nc(Br)cnc2N)nc2cnccc21.O=C(OCc1ccccc1)c1ccc(B(O)O)cc1>>CCn1c(-c2nc(-c3ccc(C(=O)OCc4ccccc4)cc3)cnc2N)nc2cnccc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130018043A1,[N-]=[N+]=NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O>>NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O,O=[Pt]=O,CCOC(C)=O,,,,val
US20110034516A1,CC1(c2cncc(CO)c2)OCCO1.CS(=O)(=O)Cl>>CC1(c2cncc(COS(C)(=O)=O)c2)OCCO1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,N#N,val
US20070254931A1,CC(=O)Nc1nc(-c2ccc(CCNC(NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)cc2)c(Cc2ccc(S(C)(=O)=O)cc2)s1.Cl>>CC(=O)Nc1nc(-c2ccc(CCNC(=N)N)cc2)c(Cc2ccc(S(C)(=O)=O)cc2)s1.Cl,,C1COCCO1,,CO,,val
US20050277671A1,CC(C)(C)OC(=O)NCC1CCN(CC2(C(=O)O)CCC2)CC1.Cc1ccc(S(=O)(=O)O)cc1>>Cc1ccc(S(=O)(=O)O)cc1.NCC1CCN(CC2(C(=O)O)CCC2)CC1,,C1CCOC1,,CCN(CC)CC,O,val
US05696146,COC(=O)Cc1ccc(O)c(O)c1.COC(OC)(c1ccc(Cl)cc1)c1ccc(Cl)cc1>>COC(=O)Cc1ccc2c(c1)OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)O2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110034654A1,O=C1CCCCC1.O=Cc1ccc([N+](=O)[O-])cc1>>O=C1CCCCC1C(O)c1ccc([N+](=O)[O-])cc1,,O,,ClC(Cl)Cl,,val
US20030008849A1,COC(=O)C1N(S(=O)(=O)c2ccc(OCC#CCCCNC(=O)OC(C)(C)C)cc2)CCSC1(C)C>>CC(C)(C)OC(=O)NCCCC#CCOc1ccc(S(=O)(=O)N2CCSC(C)(C)C2C(=O)O)cc1,,CCOC(C)=O,,[I-].[Li+],,val
US06465485B1,CC(C)(C)OC(=O)N1CCc2cccc(C#N)c2C1>>N#Cc1cccc2c1CNCC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US04246263,CI.OCCSCc1ccncc1>>COCCSCc1ccncc1,,C1CCOC1,,[H-].[Na+],,val
US20150322073A1,Cc1cc(C(=O)Nc2cc3c(cc2N[C@@H](C)c2ccccc2)N(C(C)C)C(=O)C3(C)C)cn(C)c1=O>>Cc1cc(-c2nc3cc4c(cc3n2[C@@H](C)c2ccccc2)N(C(C)C)C(=O)C4(C)C)cn(C)c1=O,,CC(=O)O,,,,val
US20150005467A1,C=COCCO.CO.COC(=O)C(C)(C)N=NC(C)(C)C(=O)OC>>C=COCC(C)C.C=COCCO,,CO,,,,val
US20050043344A1,CCOC(=O)CC(Cc1nc(CCCCN)no1)c1ccc2c(c1)OCO2.CCOC(C)=N.Cl>>CCOC(=O)CC(Cc1nc(CCCCNC(C)=N)no1)c1ccc2c(c1)OCO2.Cl,,CCO,,CCN(CC)CC,,val
US20110166142A1,O=C(Cc1ccc(O)cc1)c1ccc(O)cc1O.O=C(OC(=O)c1ccccc1)c1ccccc1>>O=c1c(-c2ccc(O)cc2)c(-c2ccccc2)oc2cc(O)ccc12,,CCN(CC)CC,,Cl,O,val
US20100292077A1,Br[Mg]CC12C=CC(CC1)C2.C=CC(Cl)c1ccccc1>>C(=Cc1ccccc1)CCC12C=CC(CC1)C2,,C1CCOC1,,,,val
US05017701,CC(=O)OCC(CCI)COC(C)=O.Nc1nc(SC(c2ccccc2)c2ccccc2)c2[nH]cnc2n1>>CC(=O)OCC(CCn1cnc2c(SC(c3ccccc3)c3ccccc3)nc(N)nc21)COC(C)=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160115126A1,CC#CC(=O)O.Cc1c[nH]c2c(C(N)=O)ccc(C3CCCNC3)c12>>CC#CC(=O)N1CCCC(c2ccc(C(N)=O)c3[nH]cc(C)c23)C1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20060167070A1,COc1ccc([N+](=O)[O-])c2ccn(S(=O)(=O)c3ccccc3)c12>>COc1ccc([N+](=O)[O-])c2cc[nH]c12,,CO,O,[Na+].[OH-],,val
US20040116464A1,CNC[C@@H](O)c1ccccc1.COCCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)sc21>>COCCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN(C)C[C@@H](O)c3ccccc3)sc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20060235033A1,CC(N)c1ccc(F)cc1.COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1N.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1ccc(F)cc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20080042129A1,C[Si](C)(C)c1cc2cc3cc4cc5cc6cc([Si](C)(C)C)c([Si](C)(C)C)cc6cc5cc4cc3cc2cc1[Si](C)(C)C>>c1ccc2cc3cc4cc5cc6ccccc6cc5cc4cc3cc2c1,,C1CCOC1,,O,,val
US20140051672A1,Cc1cnc(-c2cc(OCOCC[Si](C)(C)C)c(Br)c(OCc3ccccc3)c2)o1>>Cc1cnc(-c2cc(O)c(Br)c(OCc3ccccc3)c2)o1,,C1CCOC1,O,Cl,,val
US20090137581A1,CS(=O)(=O)c1ccccc1-c1nc2c(Cl)cccc2cc1CN.Clc1ncnc2nc[nH]c12>>CS(=O)(=O)c1ccccc1-c1nc2c(Cl)cccc2cc1CNc1ncnc2[nH]cnc12,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20150344481A1,Nc1cnccn1.O=C(CBr)c1ccc(F)cc1>>Fc1ccc(-c2cn3ccncc3n2)cc1,,CCO,,O=C([O-])O.[Na+],,val
US20090275606A1,COC(=O)C1CCCN1.O=S(=O)(Cl)Cl>>COC(=O)C1CCCN1S(=O)(=O)Cl,CN(C)c1ccncc1,Cc1ccccc1,ClCCl,Cl,,val
US20110053949A1,CC1CNCC/C1=C\c1cccc(Oc2ccc(Cl)cn2)c1.O=C(Nc1cccnc1)Oc1ccccc1>>CC1CN(C(=O)Nc2cccnc2)CC/C1=C\c1cccc(Oc2ccc(Cl)cn2)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20150191476A1,CN(C)c1ccccc1CO>>CN(C)c1ccccc1C=O,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20110172442A1,CC(C)(C)OC(=O)NCCC[C@H](NC(=O)C=Cc1ccccc1F)C(=O)O.Cl>>Cl.NCCC[C@H](NC(=O)C=Cc1ccccc1F)C(=O)O,,ClCCl,,C1COCCO1,,val
US20160046617A1,CC(C)(C)OC(=O)N(c1cscn1)S(=O)(=O)c1cc(Cl)c(F)cc1F.O=C([O-])CCNCCCc1cc(Cl)ccc1O.O=C([O-])[O-]>>COC(=O)CCNCCCc1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)N(C(=O)OC(C)(C)C)c2cscn2)cc1Cl,,CN(C)C=O,,O,,val
US20070254866A1,CCOC(=O)c1cn(N[C@@H](CO)c2ccccc2)c2c(F)c(F)c(F)c(F)c2c1=O>>CCOC(=O)c1cn2c3c(c(F)c(F)c(F)c3c1=O)OC[C@H]2c1ccccc1,,C1CCOC1,,O,[H-].[Na+],val
US20030166946A1,COC(=O)/C=C(\C)C=Cc1c(-c2ccc(F)cc2)c2ccccc2n1C(C)C.[OH-]>>COC(=O)CC(=O)/C=C/c1c(-c2ccc(F)cc2)c2ccccc2n1C(C)C,,C1CCOC1,,[Cl-].[NH4+],,val
US20010023250A1,COc1ccc2nc(Cl)cnc2c1.ClCCl.Nc1ccccc1>>COc1ccc2nc(Nc3ccccc3)cnc2c1.Cl,,ClCCl,,,,val
US20130158075A1,CCOC(=O)CC1CCC(c2ncc(-c3ccc(N)cc3)s2)CC1.Nc1cc(F)c(F)c(F)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCOC(=O)CC1CCC(c2ncc(-c3ccc(NC(=O)Nc4cc(F)c(F)c(F)c4)cc3)s2)CC1,,ClCCl,O,CCN(CC)CC,,val
US20120149662A1,CC(C)(C)C(=O)OCn1ccc2c(-c3cnn(C(CC#N)C4CCCC4)c3)cnnc21>>N#CCC(C1CCCC1)n1cc(-c2cnnc3[nH]ccc23)cn1,,CO,,[Na+].[OH-],,val
US04221798,NN1Cc2ccccc2C1.O=C=NCCCl>>c1ccc2c(c1)CN(NC1=NCCO1)C2,,Cc1ccccc1,,,,val
US06326382B1,CC(C)(C)OC(=O)N1CCC(CI)CC1.COc1cccc2c(C)noc12>>COc1cccc2c(CCC3CCCCN3C(=O)OC(C)(C)C)noc12,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20120289698A1,CC(C)(CNc1nc(C#N)ns1)c1ccc(F)cc1.OO>>CC(C)(CNc1nc(C(N)=O)ns1)c1ccc(F)cc1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040127574A1,CCOC(=O)C(Cc1cccc(OC(C)C)c1)C(O)c1ccc(F)cc1>>CC(C)Oc1cccc(CC(C(=O)O)C(O)c2ccc(F)cc2)c1,,CO,,Cl,[Na+].[OH-],val
US07671073B2,C[C@@H](C1CCC(O)(c2cccc3ncnn23)CC1)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(F)(F)C1>>C[C@@H](C1CC=C(c2cccc3ncnn23)CC1)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(F)(F)C1,,C1CCOC1,,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US20110190304A1,COc1ccc(B(O)O)cc1.C[C@H]1CN(c2nnc(Cl)c3ccccc23)CCN1C(=O)OC(C)(C)C>>COc1ccc(-c2nnc(N3CCN(C(=O)OC(C)(C)C)[C@@H](C)C3)c3ccccc23)cc1,,C1COCCO1,,[Cs+].[F-],,val
US05658944,CCCCCCC=O.CCOC(=O)C(C)(C)Oc1ccc(CCN)cc1>>CCCCCCCNCCc1ccc(OC(C)(C)C(=O)OCC)cc1,,CCO,,,,val
US20140249133A1,CCOc1cc(F)c(Cn2nc(-c3ncc(OC)c(Nc4ccncc4)n3)c3ccccc32)c(F)c1.Cl>>CCOc1cc(F)c(Cn2nc(-c3ncc(OC)c(Nc4ccncc4)n3)c3ccccc32)c(F)c1.Cl,,CO,ClCCl,,,val
US05217961,Cc1cccc(C(=O)O)c1N.Cc1ccccc1OCC(=O)Cl>>Cc1ccccc1OCC(=O)Nc1c(C)cccc1C(=O)O,,[Na+],[OH-],Cl,,val
US20080262064A1,C=CC1(C)CCC(C(C)(C)O)O1>>CCC1(C)CCC(C(C)(C)O)O1,[Pd],CO,,,,val
US20140179667A1,BrBr.Cc1c(OC(C)C)cccc1C(=O)O>>Cc1c(OC(C)C)ccc(Br)c1C(=O)O,,CC(=O)O,CO,O=S(=O)(O)O,,val
US20110172218A1,Cc1cc(C(=O)c2cc(Cl)ncn2)cc2oc(=O)[nH]c12.O=C1Nc2ccccc2C2(CCNCC2)N1>>Cc1cc(C(=O)c2cc(N3CCC4(CC3)NC(=O)Nc3ccccc34)ncn2)cc2oc(=O)[nH]c12,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20070232607A1,COC(=O)[C@@H](C)Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(C)c3)c12.O[C@@H]1CCNC1>>Cc1cc(Nc2ncnc3cccc(O[C@H](C)C(=O)N4CC[C@@H](O)C4)c23)ccc1OCc1ccccn1,,C1CCOC1,,,,val
US20130059835A1,COc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C)c1-c1cnn(C2CCN(C(=O)OC(C)(C)C)CC2)c1>>COc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C)c1-c1cnn(C2CCNCC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04410536,CN(C)CCCCl.Cc1csc2ccc3[nH]c4c(c3c12)CNCC4>>Cc1csc2ccc3c(c4c(n3CCCN(C)C)CCNC4)c12,,CN(C)C=O,,[H-].[Na+],,val
US20130210844A1,CC(C)(C)Nc1ncnc2c(N)cccc12.CC(C)(CO)C(=O)NCc1ccc(Cl)c(C(=O)O)c1F>>CC(C)(C)Nc1ncnc2c(NC(=O)c3c(Cl)ccc(CNC(=O)C(C)(C)CO)c3F)cccc12,CN(C)C=O,ClCCl,,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20040092546A1,NN.O=C(Nc1cccc(F)c1)c1ccc(C(=O)c2cccnc2Cl)[nH]1>>O=C(Nc1cccc(F)c1)c1ccc(-c2n[nH]c3ncccc23)[nH]1,,CCO,,O,,val
US04486444,Brc1cccs1.COc1ccc(C(=O)Cl)cc1>>COc1ccc(C(=O)c2ccc(Br)s2)cc1,,ClCCl,,,,val
US20130053382A1,CC(C)(C)OC(=O)NCc1cccc(B2OC(C)(C)C(C)(C)O2)c1.C[Si](C)(C)CCOCn1ncc2cc(Br)c([N+](=O)[O-])cc21>>CC(C)(C)OC(=O)NCc1cccc(-c2cc3cnn(COCC[Si](C)(C)C)c3cc2[N+](=O)[O-])c1,,CCOC(C)=O,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20100160303A1,CC(C)(CCO)C(=O)Nc1ccc2c(c1)[nH]c1c(C(N)=O)ccc(Br)c12>>CC1(C)CCN(c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(Br)c23)C1=O,,C1CCOC1,ClCCl,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030119830A1,CCOC(=O)C=O.COC(=O)c1cc2cc(N)ccc2n1Cc1ccc(Cl)c(Cl)c1>>CCOC(=O)CNc1ccc2c(c1)cc(C(=O)OC)n2Cc1ccc(Cl)c(Cl)c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US05580888,COc1ccc(C(O)c2ccccc2)cc1OC1CCCC1>>COc1ccc(C(=O)c2ccccc2)cc1OC1CCCC1,O=[Mn]=O,ClCCl,,,,val
US05116862,C#CCCCCC(C(=O)O)C(=O)O>>C#CCCCCCC(=O)O,,CC#N,,,,val
US20030092720A1,CCOC(=O)/C(C)=C/c1c(N2CCOCC2)nc2cc(CCc3nc(C4CCC4)cs3)ccn2c1=O>>C/C(=C\c1c(N2CCOCC2)nc2cc(CCc3nc(C4CCC4)cs3)ccn2c1=O)C(=O)O,,CO,,[Na+].[OH-],,val
US20160137648A1,C=CC#N.CC(C)(C)OCC(N)C(=O)O>>CC(C)(C)OCC(NCCC#N)C(=O)O,,O,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US20050165055A1,CCO.Cc1c(Sc2ccc(Cl)cc2)c2cc(Br)ccc2n1CC(=O)O.OB(O)c1ccccc1>>CCOC(=O)Cn1c(C)c(Sc2ccc(Cl)cc2)c2cc(-c3ccccc3)ccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20080293712A1,COC(=O)c1cc(OC)c(OCc2ccccc2)cc1[N+](=O)[O-]>>COC(=O)c1cc(OC)c(OCc2ccccc2)cc1N,[Fe],CC(=O)O,CO,,,val
US20100056515A1,CCC(CC)c1ccc(Cl)c2nc(Cl)n(C)c12.Cc1nc(Br)cc(Br)c1O>>CCC(CC)c1ccc(Cl)c2nc(Oc3c(Br)cc(Br)nc3C)n(C)c12,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20040229949A1,CCOC(=O)C(=Cc1cccc(OCCc2ccc(OS(C)(=O)=O)cc2)c1)OCC>>CCOC(=O)C(Cc1cccc(OCCc2ccc(OS(C)(=O)=O)cc2)c1)OCC,[Pd],CCOC(C)=O,,CC(=O)O,,val
US20070185171A1,CC(C)(C)OC(=O)N1CCC[C@H]1COc1cc([N+](=O)[O-])ccc1C(F)(F)C(F)(F)F>>O=[N+]([O-])c1ccc(C(F)(F)C(F)(F)F)c(OC[C@@H]2CCCN2)c1,,ClCCl,O=C(O)C(F)(F)F,[Na+].[OH-],,val
US04652561,CCN(CC)CCCl.COc1ccc([C@@H]2Sc3c(ccc4ccccc34)NC(=O)[C@@H]2O)cc1>>CCN(CC)CCN1C(=O)[C@H](O)[C@H](c2ccc(OC)cc2)Sc2c1ccc1ccccc21,,CCOC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150045349A1,CC(C)[C@H](C)n1cc(Br)c(Cl)c(C#N)c1=O.NN>>CC(C)[C@H](C)n1cc(Br)c2[nH]nc(N)c2c1=O,,CCO,,O,,val
US20040077647A1,COc1ccc(C(F)(F)F)cc1NC(=O)Nc1ccc(Oc2cc(C)nc(NCCN(C)C)n2)c2ccccc12.COc1ccc(CN)cc1>>COc1ccnc(NCc2ccccc2)n1,,CS(C)=O,O,CCN(CC)CC,CCOC(C)=O,val
US04916137,NC(=O)c1cnn2c1NCC=C2c1cccc(F)c1.S=C(n1ccnc1)n1ccnc1>>O=c1[nH]c(=S)n2c3c1cnn3C(c1cccc(F)c1)=CC2,,C1CCOC1,,[H-].[Na+],,val
US20140329799A1,CC(C)(C)OC(=O)N1CCC[C@@H](N)C1.O=C(OCc1ccccc1)N1CCC(c2nc(O)c(-c3nc4ccccc4s3)c(Cl)n2)CC1>>CC(C)(C)OC(=O)N1CCC[C@@H](Nc2nc(C3CCN(C(=O)OCc4ccccc4)CC3)[nH]c(=O)c2-c2nc3ccccc3s2)C1,,CCO,,CCN(C(C)C)C(C)C,,val
US20050187390A1,CC(=O)c1cc[nH]c1.O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4cc(Br)ccc4O)ccc3c1)n2C1CCCCC1>>O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4cc[nH]c4)ccc3c1)n2C1CCCCC1,,CCO,,[K+].[OH-],,val
US06166040,C1CCNCC1.Fc1ccc2cc[nH]c2c1>>Fc1ccc2c(C3=CCNCC3)c[nH]c2c1,,CO,,O,[K+].[OH-],val
US20040259907A1,CNCC(O)c1cccs1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)oc21>>CN(Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2o1)CC(O)c1cccs1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20150366977A1,CI.O=[N+]([O-])c1cc(CO)ccc1Cl>>COCc1ccc(Cl)c([N+](=O)[O-])c1,,CS(C)=O,,O,[K+].[OH-],val
US06177440B1,COC(=O)CBr.NC(=O)c1cccc2c1c1c(O)cccc1n2Cc1c(F)cccc1F>>COC(=O)COc1cccc2c1c1c(C(N)=O)cccc1n2Cc1c(F)cccc1F,,CN(C)C=O,O,,,val
US05149700,CNc1nc2ccccc2n1CCO.CS(=O)(=O)Cl>>CNc1nc2ccccc2n1CCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,O,val
US04393059,CCCCCCCCON=C(C(=O)OCC)c1csc(N)n1>>CCCCCCCCON=C(C(=O)O)c1csc(N)n1,,C1CCOC1,,CO,[Na+].[OH-],val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4cnc5n4CCCC5)cc2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4cnc5n4CCCC5)cc2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20120277224A1,CC1(C)OC(=O)C(C(=O)c2ccc3occc3c2)C(=O)O1.CCO>>CCOC(=O)CC(=O)c1ccc2occc2c1,,CCO,,CCOC(C)=O,,val
US20090093483A1,CC(C)(C)OC(=O)CNC(=O)C1=C(O)c2cc(Cl)ccc2C2(CCCCC2)C1=O>>O=C(O)CNC(=O)C1=C(O)c2cc(Cl)ccc2C2(CCCCC2)C1=O,,O=C(O)C(F)(F)F,,,,val
US05037834,Nc1ncc2c(n1)CCN(C(c1ccccc1)(c1ccccc1)c1ccccc1)C2>>Nc1ncc2c(n1)CCNC2,,CC(C)=O,,CC(=O)O,O,val
US20110218192A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C1NC(=O)C2(CC(c3cccs3)Oc3ccc(Br)cc32)N1>>O=C1NC(=S)NC12CC(c1cccs1)Oc1ccc(Br)cc12,,C1COCCO1,,,,val
US20080171743A1,C[C@H]1COCCN1c1cc(CS(=O)(=O)C2CC2)nc(-c2ccc(N)cc2)n1.O=C(Cl)Oc1ccccc1>>C[C@H]1COCCN1c1cc(CS(=O)(=O)C2CC2)nc(-c2ccc(NC(=O)Oc3ccccc3)cc2)n1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US07074742B2,NCc1ncc(C(F)(F)F)cc1Cl.O=C(O)c1c(Cl)ccnc1Cl>>O=C(NCc1ncc(C(F)(F)F)cc1Cl)c1c(Cl)ccnc1Cl,,ClCCl,O=S(Cl)Cl,CCN(CC)CC,Cl,val
US20100174065A1,CCOC(=O)CCN1CCOc2c(cccc2-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)C1>>CC(C)Oc1ccc(-c2nc(-c3cccc4c3OCCN(CCC(=O)O)C4)no2)cc1C#N,,CCO,,[Na+].[OH-],,val
US20110034451A1,CC(=O)c1cc(O)cc(C(C)(C)C)c1.FCCBr>>CC(=O)c1cc(OCCF)cc(C(C)(C)C)c1,,CN(C)C=O,,O,[H-].[Na+],val
US20080085890A1,COCCl.N#Cc1ccc(I)c(O)c1>>COCOc1cc(C#N)ccc1I,,CN(C)C=O,,[H-].[Na+],,val
US20100249093A1,BrCCCCBr.CC[C@@H](N)CO>>CC[C@H](CO)N1CCCC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US03983111,BrBr.CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](Br)C[C@]4(C)[C@H]3C(=O)C[C@]12C>>C[C@]12C[C@H](Br)[C@@H](O)C[C@@H]1CC[C@@H]1[C@@H]2C(=O)C[C@]2(C)[C@@H](C(=O)CBr)CC[C@@H]12,,CO,,O,,val
US20090069287A1,CC(C)c1cccc(C2(O)CN(C(c3ccccc3)c3ccccc3)C2)c1.CS(=O)(=O)Cl>>CC(C)c1cccc(C2(Cl)CN(C(c3ccccc3)c3ccccc3)C2)c1,,ClC(Cl)Cl,,CCN(CC)CC,O,val
US20090318689A1,CC1(C)CCC(=O)CC1.CCOC=O>>CC1(C)CCC(=O)/C(=C/O)C1,,O,,C1CCOC1,CC(C)(C)[O-].[K+],val
US20150291572A1,C1CCOC1.CC(C)Oc1ccc(C2CC(S(=O)(=O)c3cccc(C(F)(F)F)c3)CCO2)cn1>>CC(C)Oc1ccc(C2CC(C)(S(=O)(=O)c3cccc(C(F)(F)F)c3)CCO2)cn1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20130102576A1,CC(C)(C)OC(=O)CBr.COc1ccc2c(c1)NC(=O)C2=O>>COc1ccc2c(c1)N(CC(=O)OC(C)(C)C)C(=O)C2=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05397798,Nc1ccccc1C(=O)NCCc1ncc[nH]1.O=C(Cl)c1ccc[nH]1>>Cl.O=C(Nc1ccccc1C(=O)NCCc1ncc[nH]1)c1ccc[nH]1,,CCOC(C)=O,CO,CCO,,val
US20060258714A1,Cc1ccc(S(=O)(=O)OCC2C=Cc3cc(F)cc(Br)c3O2)cc1>>Cc1ccc(S(=O)(=O)OCC2CCc3cc(F)cc(Br)c3O2)cc1,[Pt],CCO,,[H][H],,val
US20110046378A1,COCOc1ccc2c(=O)c(OCOC)c(-c3ccc(OCCO)c(OCOC)c3)oc2c1.Cc1ccc(S(=O)(=O)Cl)cc1>>COCOc1ccc2c(=O)c(OCOC)c(-c3ccc(OCCOS(=O)(=O)c4ccc(C)cc4)c(OCOC)c3)oc2c1,,CCOCC,,CCN(C(C)C)C(C)C,,val
US20130109757A1,CC(=O)c1ccc(F)c(Br)c1.O=[N+]([O-])C=C(c1cc(Cl)c(Cl)c(Cl)c1)C(F)(F)F>>O=C(CC(C[N+](=O)[O-])(c1cc(Cl)c(Cl)c(Cl)c1)C(F)(F)F)c1ccc(F)c(Br)c1,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US04606757,CS.Clc1cccc(C(Oc2ccccc2)Oc2ccccc2)n1>>CSc1cccc(C(Oc2ccccc2)Oc2ccccc2)n1,,CO,CS(C)=O,[Na],C[O-].[Na+],val
US20060229309A1,CCCC[Sn](CCCC)(CCCC)c1ncco1.COC[C@H]1CCCN1C(=O)c1cc(Br)cc(C(=O)OC)c1>>COC[C@H]1CCCN1C(=O)c1cc(C(=O)O)cc(-c2ncco2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,CCOC(C)=O,,val
US06297198B1,CSC(SC)=C(C(=O)c1ccc(S(C)(=O)=O)cc1Cl)C(=O)C1CC1.NO>>CSc1noc(C2CC2)c1C(=O)c1ccc(S(C)(=O)=O)cc1Cl,,CCO,,Cl,CC(=O)[O-].[Na+],val
US04371536,CN.COC(=O)c1cc2c(cn1)[nH]c1ccccc12>>CNC(=O)c1cc2c(cn1)[nH]c1ccccc12,,CO,,,,val
US20100267769A1,CC(C)(C)OC(=O)c1ccc2nc(C(F)(F)F)ccc2c1>>O=C(O)c1ccc2nc(C(F)(F)F)ccc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06025372,CC(C)(C)OC(=O)N1CCNCC1.CCOCC.N#CCCl>>CCCCOC(=O)N1CCN(CC#N)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100075948A1,CC(C)(C)C/C=N/CC(=O)OC(C)(C)C.N#C/C(=C\c1cccc(Br)c1F)c1ccc(Cl)cc1F>>CC(C)(C)CC1NC(C(=O)OC(C)(C)C)C(c2cccc(Br)c2F)C1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(CC)CC,,val
US20150175623A1,CCOC(=O)c1cnnn1CCOC>>COCCn1nncc1CO,,O,,CCO,,val
US20120022092A1,CC1(C)CC(Nc2nc(Cl)ncc2F)CC(C)(C)N1.Nc1cc(-n2nnnc2C2CC2)c(C2CC2)cc1F>>CC1(C)CC(Nc2nc(Nc3cc(-n4nnnc4C4CC4)c(C4CC4)cc3F)ncc2F)CC(C)(C)N1,,CC(C)O,,Cl,,val
US20070032518A1,COC(=O)c1ccc(CO)c([N+](=O)[O-])c1>>COC(=O)c1ccc(CO)c(N)c1,[Fe],CCO,,[Cl-].[NH4+],,val
US20090143372A1,CC1(C)OB(c2cc(C=O)c3c(c2)OCC3)OC1(C)C.CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(Br)cc23)CC1>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cc(C=O)c5c(c4)OCC5)cc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20150038498A1,CC(=O)O[C@@H](C(=O)Cl)C(C)(C)C.CC(C)(C)OC(=O)NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CSCCN1>>CC(=O)O[C@@H](C(=O)N1CCSC[C@H]1C(=O)NCc1cc(Cl)ccc1CNC(=O)OC(C)(C)C)C(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20050124622A1,CC(C)(C)OC(=O)NN.COc1ccc(-c2nnc(CCl)o2)cc1>>COc1ccc(-c2nnc(CNNC(=O)OC(C)(C)C)o2)cc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20150158863A1,CCOC(=O)C(Br)CC.Oc1ccc(OC(F)(F)F)cc1>>CCOC(=O)C(CC)Oc1ccc(OC(F)(F)F)cc1,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US04387238,CC[K].NCCCCNC(=O)OCc1ccccc1.O=C(O)C1OC1C(=O)O>>CCOC(=O)C1OC1C(=O)NCCCCNC(=O)OCc1ccccc1,,CCOCC,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20110275673A1,CCCCCCS.O=[N+]([O-])c1ccc(CBr)cc1>>CCCCCCSCc1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,CN1CCCC1=O,[H-].[Na+],,val
US20110301175A1,COC(=O)Cc1cc(N)ccc1C>>Cc1ccc(N)cc1CCO,,C1CCOC1,,,,val
US05243054,Cc1cccc(-c2ccccc2)c1C(=O)O.NN>>Cc1ccc(-c2ccccc2C(=O)NN)cc1,CN(C)C=O,C1CCOC1,O,O=C(Cl)C(=O)Cl,,val
US20040167335A1,Fc1ccc(-c2nn3ccc(NC4CCCC4)cc3c2-c2ccnc(NC3CCCC3)n2)cc1.O=C1CCC(=O)N1Br>>Fc1ccc(-c2nn3ccc(NC4CCCC4)c(Br)c3c2-c2ccnc(NC3CCCC3)n2)cc1,,ClCCl,,[Na+].[OH-],,val
US05968920,CC(=O)Cl.CC1(C)N[Se]c2ccccc21>>CC(=O)N1[Se]c2ccccc2C1(C)C,,CCOCC,,CCN(CC)CC,O,val
US05310743,O=C(Cc1ccccc1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1>>O=C(Cc1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20080119466A1,O=[N+]([O-])c1ccc(-n2cnc3cnccc32)cc1>>ONc1ccc(-n2cnc3cnccc32)cc1,[Zn],C1COCCO1,,[Cl-].[NH4+],,val
US20110237565A1,CC(C)(C)OC(=O)N1CCN(c2ncc(Br)n3cnnc23)CC1.OB(O)c1ccoc1>>CC(C)(C)OC(=O)N1CCN(c2ncc(-c3ccoc3)n3cnnc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US06734200B1,CC(C)(C)OC(=O)N[C@H]1CCN(c2ccc(N3C[C@H](CN(C(=O)OCC(Cl)(Cl)Cl)c4ccon4)OC3=O)cc2F)C1>>N[C@H]1CCN(c2ccc(N3C[C@H](CN(C(=O)OCC(Cl)(Cl)Cl)c4ccon4)OC3=O)cc2F)C1,,CCO,ClCCl,Cl,,val
US20080293713A1,CCC(=O)CC#N.Nc1nc[nH]n1>>CCc1cc(N)n2ncnc2n1,,CC(=O)O,,,,val
US20060106020A1,CO.Cc1ncnc(Cl)c1Br>>COc1ncnc(C)c1Br,,CO,,C[O-].[Na+],,val
US20080269220A1,CCCI.COC(=O)CCc1ccc(NCc2cccc(-c3c(C)cccc3C)c2)cc1>>CCCN(Cc1cccc(-c2c(C)cccc2C)c1)c1ccc(CCC(=O)OC)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090197962A1,C=CCOC(=O)CCC/C=C\C[C@H]1[C@H](Cl)C[C@@H](OC2CCCCO2)[C@@H]1CO>>CCCOC(=O)CCCCCC[C@H]1[C@H](Cl)C[C@@H](OC2CCCCO2)[C@@H]1CO,O=[Pt]=O,CCOC(C)=O,,[H][H],,val
US05338736,C=C[Mg]Br.CCCCc1nc(=O)c2cc(C=O)ccc2[nH]1>>C=CC(O)c1ccc2[nH]c(CCCC)nc(=O)c2c1,,C1CCOC1,,,,val
US20070249591A1,CCOC(=O)c1csc(-c2ccc([N+](=O)[O-])cc2)n1>>CCOC(=O)c1csc(-c2ccc(N)cc2)n1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20080176883A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1[C@H](N)CCN1[C@H](CO)c1ccccc1>>CC1[C@H](NC(=O)OC(C)(C)C)CCN1[C@H](CO)c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20080200494A1,Cc1c(C2CC2)nc2ccc([N+](=O)[O-])cn12.Cl.O=C(O)c1ccc(-c2ccc(F)cc2)nc1>>Cc1c(C2CC2)nc2ccc(NC(=O)c3ccc(-c4ccc(F)cc4)nc3)cn12.Cl,,CCOC(C)=O,,,,val
US20110020460A1,CC(C)OC(=O)N1CCC(n2ncc(CO)c2C#N)CC1.C[Si](C)(C)OCCn1nnc(-c2ccc(O)c(F)c2)n1>>CC(C)OC(=O)N1CCC(n2ncc(COc3ccc(-c4nnn(CCO[Si](C)(C)C)n4)cc3F)c2C#N)CC1,,C1COCCO1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05061703,Br.OC12CC3CC(C1)CC(c1ccccc1)(C3)C2>>BrC12CC3CC(C1)CC(c1ccccc1)(C3)C2,,CC(=O)O,O,,,val
US06090828,CCCCn1nc(C(OC)OC)nc1Cc1ccc(-c2ccccc2-c2nnn[nH]2)nc1>>CCCCn1nc(C=O)nc1Cc1ccc(-c2ccccc2-c2nnn[nH]2)nc1,,CC(C)=O,,O=S(=O)(O)O,,val
US04156609,CC(=O)OC(C)=O.O=S(=O)(F)c1cccc(N=Nc2cc(Cl)c(O)c(C=NO)c2)c1>>CC(=O)Oc1c(Cl)cc(N=Nc2cccc(S(=O)(=O)F)c2)cc1C#N,,O,,CC(=O)[O-].[Na+],,val
US20090306042A1,CC(C)(C)OC(=O)NC(=O)[C@@H](N)Cc1ccc(I)cc1>>NC(=O)[C@@H](N)Cc1ccc(I)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04742060,N#Cc1ccc(CCl)cn1.NCCN>>N#Cc1ccc(CNCCN)cn1,,CC#N,,,,val
US20100197683A1,CC#N.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n([C@@H]2CC[C@@H](OC(C)C(O)CF)CC2)c2ncnn12>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n([C@@H]2CC[C@@H](OC(C)C3(CF)CO3)CC2)c2ncnn12,,CC#N,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20100160430A1,CSC(CCOS(C)(=O)=O)C(F)(F)F.N#CCS(=O)(=O)CCC(F)(F)F>>CSC(CCC(C#N)S(=O)(=O)CCC(F)(F)F)C(F)(F)F,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130225620A1,COC(C)(OC)OC.Cl[Sn]Cl.Nc1cccc(Br)c1N>>Cc1nc2c(Br)cc(Cl)cc2[nH]1,,CCO,,,,val
US20040058965A1,CCOC(=O)CCc1cc(OCC)ccc1O.Cc1oc(-c2ccccc2)nc1COc1ccc(CCl)cc1>>CCOC(=O)CCc1cc(OCC)ccc1OCc1ccc(OCc2nc(-c3ccccc3)oc2C)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US07235572B2,Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CC#N.O.[OH-]>>Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CC(=O)O,,CCO,,Cl,,val
US20150291558A1,Cc1c(C#N)ccnc1O[C@@H]1CC[C@@H](C)N(C(=O)c2ccc(O)nc2-n2nccn2)C1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1c(C#N)ccnc1O[C@@H]1CC[C@@H](C)N(C(=O)c2ccc(OS(=O)(=O)C(F)(F)F)nc2-n2nccn2)C1,,ClCCl,,c1ccncc1,,val
US20070043066A1,CC(C)(C)OC(=O)CCC(NC(=O)c1ccc(-c2ccc(N)cc2)cc1)C(=O)OC(C)(C)C.O=C(O)Cc1ccccc1>>CC(C)(C)OC(=O)CCC(NC(=O)c1ccc(-c2ccc(NC(=O)Cc3ccccc3)cc2)cc1)C(=O)OC(C)(C)C,CN(C)c1ccncc1,CN(C)C=O,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US20100160352A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@H]1CCCN1>>COC(=O)[C@H]1CCCN1C(=O)OC(C)(C)C,,CC(C)(C)O,,CCN(CC)CC,,val
US07074819B2,COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2CCCCCCCCCN2CCN(CCCC(F)(F)C(F)(F)F)CC2)cc1>>CC1(c2ccc(O)cc2)COc2cc(O)ccc2C1CCCCCCCCCN1CCN(CCCC(F)(F)C(F)(F)F)CC1,,CO,Cl,,,val
US06066704,COCCl.Cc1cc(Br)c(O)c(C(C)(C)C)c1>>COCOc1c(Br)cc(C)cc1C(C)(C)C,,O,,C1CCOC1,[H-].[Na+],val
US20070105904A1,O=[N+]([O-])/C=C/c1ccc(Oc2ccccc2)cc1>>O=[N+]([O-])CCc1ccc(Oc2ccccc2)cc1,,CO,,O,[BH4-].[Na+],val
US20150141406A1,CC1(C)OB(c2ccc(C#N)cc2)OC1(C)C.CCC(COC)n1cc(I)c2c(OC)nccc21>>CCC(COC)n1cc(-c2ccc(C#N)cc2)c2c(OC)nccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20060004021A1,CNC(=O)CC(C)n1nnc(-c2cccc(Cl)c2)n1.NNC(=O)c1ccncc1>>CC(Cc1nnc(-c2ccncc2)n1C)n1nnc(-c2cccc(Cl)c2)n1,,ClCCl,,Cc1cccc(C)n1,O=C(Cl)C(=O)Cl,val
US20160221973A1,COC(=O)c1ccc(CBr)c(Br)c1.Cc1ccc([C@H](N)CO)cc1>>COC(=O)c1ccc(CN[C@H](CO)c2ccc(C)cc2)c(Br)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150031690A1,CCOC(=O)C[C@](N[S@@](=O)C(C)(C)C)(c1ccccc1F)C(F)F>>CC(C)(C)[S@](=O)N[C@@](CC=O)(c1ccccc1F)C(F)F,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20040204584A1,C1CCNC1.COc1ccc(C2COCCO2)c2sc(NC(=O)c3ccnc(CCl)c3)nc12>>COc1ccc(C2COCCO2)c2sc(NC(=O)c3ccnc(CN4CCCC4)c3)nc12,,ClC(Cl)Cl,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160108056A1,COC(=O)c1cc2ccc(NS(C)(=O)=O)cc2s1>>CS(=O)(=O)Nc1ccc2cc(C(=O)O)sc2c1,,C1CCOC1,O,Cl,[Li]O,val
US20040043998A1,BrCc1ccccc1.CSc1nc2ccnn2c(O)c1C#N>>CSc1nc2ccnn2c(OCc2ccccc2)c1C#N,,O,,CN(C)C=O,[H-].[Na+],val
US20090036450A1,CC1N=CC(CNC(=O)c2cc(NC(=O)c3cc(F)c(F)cc3Cl)[nH]n2)(Cc2ccccc2)O1.Cc1ccc(S(=O)(=O)O)cc1>>Cc1ccc(S(=O)(=O)O)cc1.Cc1nc(Cc2ccccc2)c(CNC(=O)c2cc(NC(=O)c3cc(F)c(F)cc3Cl)[nH]n2)o1,,CCOC(C)=O,,O,,val
US20060281711A1,Clc1cc(N2CCOCC2)nc(OCCN2CCOCC2)n1.NN>>NNc1cc(N2CCOCC2)nc(OCCN2CCOCC2)n1,,C1COCCO1,,,,val
US20080139558A1,Cc1ncsc1C(=O)C(Cc1cc(=O)[nH]c2c(F)cccc12)C(=O)c1cccc(Cl)c1.NN>>Cc1ncsc1-c1[nH]nc(-c2cccc(Cl)c2)c1Cc1cc(=O)[nH]c2c(F)cccc12,,CCO,CO,,,val
US20150105388A1,O=C(OO)c1cccc(Cl)c1.O=C(c1cc(-c2cc(F)cc(OC(F)(F)F)c2)n(-c2cccnc2)n1)N1CCSC1>>O=C(c1cc(-c2cc(F)cc(OC(F)(F)F)c2)n(-c2cccnc2)n1)N1CCS(=O)C1,,ClCCl,,,,val
US20160075657A1,C[C@H](NC(=O)OC(C)(C)C)c1ccc(C=O)cc1.FC1CNCc2ccc(OCC3CC3)cc21>>C[C@H](N)c1ccc(CN2Cc3ccc(OCC4CC4)cc3C(F)C2)cc1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100137386A1,COc1ccc(Nc2nc(C(N)=O)c(NC(=O)c3ccc(N)cc3)s2)cc1.O=C(Cl)CBr>>COc1ccc(Nc2nc(C(N)=O)c(NC(=O)c3ccc(NC(=O)CBr)cc3)s2)cc1,,C1CCOC1,O,CCN(CC)CC,,val
US20150353553A1,Br[Mg]c1ccccc1.CC(C)(C)[S@](=O)/N=C/C1CCC1>>CC(C)(C)S(=O)NC(c1ccccc1)C1CCC1,,ClCCl,,,,val
US20080221178A1,CCC(CC)C(=O)Cl.Nc1cc(NS(=O)(=O)c2ccccc2)ccc1NCC1CCCCC1>>CCC(CC)c1nc2cc(NS(=O)(=O)c3ccccc3)ccc2n1CC1CCCCC1,CN(C)c1ccncc1,ClCCl,,,,val
US05654428,Brc1ccc2ncccc2c1.CC(=O)NCC1CN(c2ccc([Sn](C)(C)C)c(F)c2)C(=O)O1>>CC(=O)NCC1CN(c2ccc(-c3ccc4ncccc4c3)c(F)c2)C(=O)O1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US04128560,COC(=O)CCC1(C)CCCCC1=O.NNc1ccccc1>>CC12CCCc3c1n(c1ccccc31)C(=O)CC2,,CCO,,,,val
US20110269712A1,CN[C@H]1c2ccccc2CC[C@@H]1C.Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C(=O)Cl)cs2)CC1>>Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C(=O)N(C)[C@H]3c4ccccc4CC[C@@H]3C)cs2)CC1,,ClCCl,,CCN(CC)CC,,val
US05693813,CCOC(=O)c1cc(C2CC2)c2c(C)c(O)c(F)cn2c1=O.O=P(Cl)(Cl)Cl>>CCOC(=O)c1cc(C2CC2)c2c(C)c(Cl)c(F)cn2c1=O,,ClCCl,,CN(C)C=O,,val
US20130196974A1,Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(Cl)c2c1.NC(CO)CO>>Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(NC(CO)CO)c2c1,,CN1CCCC1=O,O,,,val
US20140228361A1,CC(=O)C1CN(C(=O)OC(C)(C)C)CCC1=O.NN>>Cc1n[nH]c2c1CN(C(=O)OC(C)(C)C)CC2,,CCO,,O,,val
US20130156722A1,C=C(C)C(=O)NCC(=O)NCC(=O)O.SC1=NCCS1>>C=C(C)C(=O)NCC(=O)NCC(=O)N1CCSC1=S,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US04816454,CSc1ccc(C(=O)C(C)CC(=O)O)cc1.NN>>CSc1ccc(C2=NNC(=O)CC2C)cc1,,CC(C)O,,O,,val
US05021413,CN(C)CC1COCCN1.O=C1CC(C(=O)Cl)c2ccc(Cl)cc21>>CN(C)CC1COCCN1C(=O)C1CC(=O)c2cc(Cl)ccc21.Cl,,CCN(CC)CC,,,,val
US20060079528A1,COC(=O)CP(=O)(OC)OC.O=Cc1ccc2ccccc2n1>>COC(=O)/C=C/c1ccc2ccccc2n1,,C1CCOC1,,[H-].[Na+],,val
US05091305,NC(=O)c1ccc[n+]([C@@H]2O[C@H](COP(=O)([O-])OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1>>NC(=O)C1=CN([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)C=CC1,,O,,,,val
US20110311474A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(C(=O)CC3CCN(C(=O)OC(C)(C)C)CC3)c(Cl)cnc21.NN>>CC(C)(C)OC(=O)N1CCC(CC(=NN)c2c(Cl)cnc3[nH]ccc23)CC1,,CCO,,CC(=O)O,,val
US20040142925A1,COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(C)=O)CC2>>COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)NCC2,,Cl,,O=C([O-])[O-].[K+].[K+],,val
US05532236,O=c1[nH]c2cc([N+](=O)[O-])c(F)cc2n2c(=O)[nH]nc12.c1c[nH]cn1>>O=c1[nH]c2cc([N+](=O)[O-])c(-n3ccnc3)cc2n2c(=O)[nH]nc12,,CN(C)C=O,,,,val
US20120184542A1,COc1ncc2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1.NCc1ccccc1Cl>>COc1ncc2cc(C(=O)Nc3cc(C(=O)NCc4ccccc4Cl)ccc3Cl)c(=O)[nH]c2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090318428A1,Nc1ccc(Oc2ccccc2)nc1.O=C(Cl)c1ccc(Cl)c(C(=O)Nc2cnc3[nH]ccc3c2)c1>>O=C(Nc1ccc(Oc2ccccc2)nc1)c1ccc(Cl)c(C(=O)Nc2cnc3[nH]ccc3c2)c1,,ClCCl,,,,val
US04472409,CSc1nc2ccc(C(F)(F)F)cc2[nH]1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc2ccc(C(F)(F)F)cc2[nH]1,,ClCCl,,,,val
US04278685,COC(=O)Cn1c(Cl)ccc1Cl.N>>NC(=O)Cn1c(Cl)ccc1Cl,,CCOCC,,,,val
US05684017,COc1ccccc1.O=C(Cl)c1cc(=O)c2ccccc2o1>>COc1ccc(C(=O)c2cc(=O)c3ccccc3o2)cc1,,COc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20120232083A1,Cc1ccc(S(=O)(=O)OC2COC2)cc1.Oc1ccc(Br)cc1>>Brc1ccc(OC2COC2)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US05561101,CC(=O)OC(C)=O.COc1cc(OC)nc(C2(O)OC(=O)c3c(Cl)cccc32)n1>>COc1cc(OC)nc(C2(OC(C)=O)OC(=O)c3c(Cl)cccc32)n1,,c1ccncc1,,Cl,,val
US06689806B1,O=C1Cc2c(CCO)cccc2N1.O=C=Nc1ccccc1-c1ccccc1>>O=C1Cc2c(CCOC(=O)Nc3ccccc3-c3ccccc3)cccc2N1,c1ccncc1,C1CCOC1,CN(C)C=O,,,val
US20110195954A1,Fc1cc2c(cc1F)NCC2.O=C(O)c1ccnc(Cl)c1>>O=C(c1ccnc(Cl)c1)N1CCc2cc(F)c(F)cc21,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US07109229B2,BrC(Br)(Br)Br.CN1C=c2c(c3c4c([nH]c3c3cc(CCCO)c5c(c23)N=CC=5)C=CC(=O)C4)C1=O>>CN1C=c2c(c3c4c([nH]c3c3cc(CCCBr)c5c(c23)N=CC=5)C=CC(=O)C4)C1=O,,CCOC(C)=O,CN(C)C=O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100004239A1,CC(O)C(=O)O.CCN(CC)CCN1CCc2[nH]c(C=C3C(=O)Nc4ccc(F)cc43)c(C)c2C1=O>>CC(O)C(=O)O.CCN(CC)CCN1CCc2[nH]c(C=C3C(=O)Nc4ccc(F)cc43)c(C)c2C1=O,,CO,,ClCCl,,val
US20150197511A1,CN1CCNCC1.O=[N+]([O-])c1cc(CCl)cc(C(F)(F)F)c1>>CN1CCN(Cc2cc([N+](=O)[O-])cc(C(F)(F)F)c2)CC1,,C1CCOC1,,CCOC(C)=O,,val
US20060205790A1,CC(C)(C)[Si](C)(C)OCCc1ccc(O)c(I)c1.c1ccc(COC[C@H]2CO2)cc1>>CC(C)(C)[Si](C)(C)OCCc1ccc(OC[C@@H](O)COCc2ccccc2)c(I)c1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20140031360A1,COc1cc(-c2cn(S(=O)(=O)c3ccc(C)cc3)c3ccc(-c4c(F)cccc4F)cc23)nc(N[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)n1>>COc1cc(-c2c[nH]c3ccc(-c4c(F)cccc4F)cc23)nc(N[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)n1,,C1COCCO1,,[Na+].[OH-],,val
US04808587,Cn1c(=O)c2c(N=[N+]=[N-])ccnc2n(C)c1=O>>Cn1c(=O)c2c(N)ccnc2n(C)c1=O,[Pd],CO,,C,,val
US06034078,CC(C)Br.Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1>>Cc1cc2c(s1)N(C(C)C)c1ccccc1N=C2N1CCN(C)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US20080015184A1,CC(C)Cn1c(CCCCN)nc2c(N)nc3ccccc3c21.O=C(Cl)N1CCOCC1>>CC(C)Cn1c(CCCCNC(=O)N2CCOCC2)nc2c(N)nc3ccccc3c21,,ClCCl,,CCN(CC)CC,,val
US20030195200A1,CCOC(=O)[C@H](Cc1ccc(OCC=Cc2ccc3ccccc3n2)cc1)OCC>>CCO[C@@H](Cc1ccc(OCC=Cc2ccc3ccccc3n2)cc1)C(=O)O,,CCO,,[Na+].[OH-],,val
US20110237628A1,CCOC(=O)C(C)(C)Oc1ccc(N)c(F)c1.O=C(O)C(c1c2c(nn1-c1ccc(Cl)cc1)CCCCC2)C1CCCCC1>>CCOC(=O)C(C)(C)Oc1ccc(NC(=O)C(c2c3c(nn2-c2ccc(Cl)cc2)CCCCC3)C2CCCCC2)c(F)c1,CN(C)c1ccncc1,ClCCl,O=S(Cl)Cl,,,val
US20080004327A1,COC(=O)c1cc2occc2[nH]1.O=C1CCC(=O)N1Br>>COC(=O)c1[nH]c2ccoc2c1Br,,ClCCl,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110098296A1,Cc1nc(-c2cccc([N+](=O)[O-])c2)c(-c2ccnc(Nc3ccc(OCCN(C)C)c(Cl)c3)n2)s1>>Cc1nc(-c2cccc(N)c2)c(-c2ccnc(Nc3ccc(OCCN(C)C)c(Cl)c3)n2)s1,[Pd],CCO,,CC(=O)O,,val
US20050209284A1,CN(C(=O)c1ccccc1)c1ccc(F)c([N+](=O)[O-])c1.CN(C)C=O.NCCC(N)=O>>CN(C(=O)c1ccccc1)c1ccc2c(c1)nc(N)n2CCC(N)=O,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,O,val
US04957971,CC(C)c1nn(-c2nc3ccccc3s2)c(-c2ccc(F)cc2)c1/C=C/C=O.CCOC(=O)CC(C)=O>>CCOC(=O)CC(=O)CC(O)/C=C/c1c(C(C)C)nn(-c2nc3ccccc3s2)c1-c1ccc(F)cc1,,C1CCOC1,,[Li]CCCC,[H-].[Na+],val
US20160244417A1,CN(C)C(OC(C)(C)C)OC(C)(C)C.COC(=O)[C@@H]1CC(F)(F)CC[C@H]1C(=O)O>>COC(=O)[C@@H]1CC(F)(F)CC[C@H]1C(=O)OC(C)(C)C,,Cc1ccccc1,,,,val
US20150133400A1,CCOC(=O)c1ccc(Cl)nc1.Cc1noc(C)c1-c1cnc2[nH]cc(CC3CCC(F)(F)CC3)c2c1>>CCOC(=O)c1ccc(-n2cc(CC3CCC(F)(F)CC3)c3cc(-c4c(C)noc4C)cnc32)nc1,,CN1CCCC1=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20080132551A1,CCOc1ccc(N)c(Nc2ccccn2)c1.Cc1cc(NC(=O)Oc2ccccc2)no1>>CCOc1ccc(NC(=O)Nc2cc(C)on2)c(Nc2ccccn2)c1,,C1CCOC1,,,,val
US20160251320A1,CC1(C)OCC(CO)O1.COc1cccc2c1[n+]([O-])c1cccc(OC(=O)CCl)c1[n+]2[O-]>>CC1(C)OCC(COCC(=O)Oc2cccc3c2[n+]([O-])c2cccc(O)c2[n+]3[O-])O1,,C1CCOC1,,,,val
US06008237,C=CCBr.Oc1ccc2c(CCc3ccccc3)coc2c1>>C=CCOc1ccc2c(CCc3ccccc3)coc2c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050197327A1,C=CC(=O)N(CCN)C(c1nc(C#N)c(C)c(=O)n1Cc1ccccc1)C(C)C>>Cc1c(C#N)nc(C(C(C)C)N2CCNCCC2=O)n(Cc2ccccc2)c1=O,,CO,,,,val
US20110034512A1,COC(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1>>O=C(O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1,,CCO,,[Na+].[OH-],,val
US20100286140A1,COc1ccc(-c2nnc3c4ccccc4c(Cl)nn23)cc1.Nc1ccc(N)cc1>>COc1ccc(-c2nnc3c4ccccc4c(Nc4ccc(N)cc4)nn23)cc1,,CCO,,,,val
US20030069261A1,CC1(c2ccccc2)CCNCC1.NCCCBr>>CC1(c2ccccc2)CCN(CCCN)CC1,,C1COCCO1,,Br,O=C([O-])[O-].[K+].[K+],val
US20100210628A1,CC(C)(C)C1CC(C(=O)NCc2ccc(Cl)cc2Cl)CCN1C(=O)[O-]>>O=C(NCc1ccc(Cl)cc1Cl)C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120094964A1,COC(=O)c1ccc(S(=O)(=O)Cl)cc1.Nc1ncc(Cl)cc1Cl>>COC(=O)c1ccc(S(=O)(=O)Nc2ncc(Cl)cc2Cl)cc1,CN(C)c1ccncc1,,,,,val
US20040147748A1,COC(=O)c1cnc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)cn1>>CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2cnc(CO)cn2)cc1Cl,,CO,,[BH4-].[Na+],,val
US20100130446A1,CC(C)(C)[Si](OCc1nnc(-c2ccc(C(CC3CCOCC3)c3ccc(S(=O)(=O)C4CC4)cc3)[nH]2)s1)(c1ccccc1)c1ccccc1>>O=S(=O)(c1ccc(C(CC2CCOCC2)c2ccc(-c3nnc(CO)s3)[nH]2)cc1)C1CC1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100190763A1,COC(=O)[C@@H]1CCCCN1.COC(=O)c1cnc(Cl)c([N+](=O)[O-])c1>>COC(=O)c1cnc(N2CCCC[C@H]2C(=O)OC)c([N+](=O)[O-])c1,,CCOC(C)=O,,,,val
US04002647,CC(C)=CCCC(C)=CCOc1ccc2c(c1)OCC2.O=C(OO)c1cccc(Cl)c1>>CC(=CCOc1ccc2c(c1)OCC2)CCC1OC1(C)C,,ClCCl,,,,val
US04640913,CCCCCCCCCCCCCCCCCCC(CO)CC1(C)OCCO1>>CCCCCCCCCCCCCCCCCCC(CO)CC(C)=O,,CC(C)=O,,,,val
US05593988,CCCCCCCCC=Cc1ccc([N+](=O)[O-])cc1>>CCCCCCCCCCc1ccc(N)cc1,[Pd],CC(=O)O,,,,val
US20150291617A1,O=C1CCCCN1c1nc(Br)cs1.OB(O)c1ccc(Cl)cc1>>O=C1CCCCN1c1nc(-c2ccc(Cl)cc2)cs1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[K+].[K+],val
US20110015199A1,CC(C)(C)OC(=O)N1CCC(COc2ccc(C3=CCN(S(C)(=O)=O)CC3)cc2)CC1>>CS(=O)(=O)N1CC=C(c2ccc(OCC3CCNCC3)cc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US05438141,Cc1ccc2cc(F)c(F)cc2n1.O=Cc1cccc(C=O)c1>>O=Cc1cccc(C=Cc2ccc3cc(F)c(F)cc3n2)c1,,Cc1ccccc1C,,CC(=O)OC(C)=O,,val
US05387684,CCOC(=O)c1ccccc1-n1cc2cc(C)ccc2n1.O=C1CCC(=O)N1Br>>CCOC(=O)c1ccccc1-n1nc2ccc(C)cc2c1Br,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US04933330,COC(=O)c1cc(N)ccc1O.O=Cc1ccccc1>>COC(=O)c1cc(N=Cc2ccccc2)ccc1O,,CCO,,,,val
US20100317657A1,CC(=O)Cl.COc1cc(Br)cnc1CO>>COc1cc(Br)cnc1COC(C)=O,,ClCCl,,CCN(CC)CC,,val
US20110312976A1,COC(=O)c1ccccc1S(=O)(=O)Cl.Nc1cc(F)cc(Oc2cccnc2)c1>>COC(=O)c1ccccc1S(=O)(=O)Nc1cc(F)cc(Oc2cccnc2)c1,,c1ccncc1,,O,[Cl-].[NH4+],val
US04536391,CC(C)(C)OC(=O)CCc1ccc(CCCO)cc1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)CCc1ccc(CCCOS(C)(=O)=O)cc1,,ClCCl,,CCN(CC)CC,,val
US20150210682A1,COCCCBr.Oc1cc(Br)cc(F)c1F>>COCCCOc1cc(Br)cc(F)c1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120053173A1,Br[Mg]C1CCCCC1.Cc1ccc2oc(C=O)c(C)c2c1>>Cc1ccc2oc(C(O)C3CCCCC3)c(C)c2c1,,C1CCOC1,,[Cl-].[NH4+],,val
US20090088322A1,CCCC[Sn](C#C[Si](C)(C)C)(CCCC)CCCC.COC(=O)c1nc(-c2ccc(Cl)c(OC)c2F)cc(NC(C)=O)c1Cl>>COC(=O)c1nc(-c2ccc(Cl)c(OC)c2F)cc(NC(C)=O)c1C#C[Si](C)(C)C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,ClCCCl,,,,val
US20130096133A1,CCOC(=O)CN1CCN(Cc2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)CC1.NN>>NNC(=O)CN1CCN(Cc2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)CC1,,CCO,,,,val
US20110230461A1,COC(=O)Cc1nn2ccccc2c1C(=O)OC>>COC(=O)Cc1nn2c(c1C(=O)OC)CCCC2,[Pd],CO,,,,val
US20110021537A1,CCOC(=O)N1CCN(C(=O)[C@H](CCN)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)n(-c3ccccc3)n2)CC1.O=C(O)C1CC1(F)F>>CCOC(=O)N1CCN(C(=O)[C@H](CCNC(=O)C2CC2(F)F)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)n(-c3ccccc3)n2)CC1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05733912,CCCc1cc(C23CCCN2CCC3)on1.Cl>>CCCc1cc(C23CCCN2CCC3)on1.Cl,,CCOCC,,,,val
US20130331378A1,COC(=O)c1cccc(C(O)c2c(N3CCOCC3)nn3c([Si](C)(C)C)c(Cl)ccc23)n1>>COC(=O)c1cccc(C(O)c2c(N3CCOCC3)nn3cc(Cl)ccc23)n1,,C1CCOC1,,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US03966760,COc1cc(C=O)c([N+](=O)[O-])cc1OC.NCC1CCCCO1>>COc1cc(C=C2CCCOC2CN)c([N+](=O)[O-])cc1OC,,CCO,,,,val
US20080261940A1,CN.N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(Br)c1[N+](=O)[O-]>>CNc1c([N+](=O)[O-])c(C#N)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl,,CCOC(C)=O,,O,,val
US20050107428A1,CO/C=C1\C(=O)OC(=O)c2ccc(F)cc21>>COC(=O)c1coc(=O)c2ccc(F)cc12,,CO,,O=S(=O)(O)O,,val
US20090118357A1,O=C(O)c1cc([N+](=O)[O-])cc2c1OCC2>>Nc1cc2c(c(C(=O)O)c1)OCC2,,CO,,,,val
US04210754,C1COCCN1.O=C(c1ccc(Cl)cc1)N1CC1>>O=C(NCCN1CCOCC1)c1ccc(Cl)cc1,,Cc1ccccc1,,,,val
US20090221653A1,C=CCSCCCO.Cc1ccc(S(=O)(=O)Cl)cc1>>C=CCSCCCOS(=O)(=O)c1ccc(C)cc1,CN(C)c1ccncc1,ClC(Cl)Cl,ClCCl,CCN(CC)CC,,val
US20140378475A1,COc1cccc2c(=O)oc(=O)[nH]c12.Cc1c(N)cccc1Br>>COc1cccc(C(=O)Nc2cccc(Br)c2C)c1N,,Cc1ccccc1,,C[Al](C)C,Cl,val
US20130336921A1,CN(CCN1CCOCC1)C(=O)c1cccc(C(=O)Cl)c1.Nc1ccc(N2CCCCC2)cc1C(=O)Nc1nc(-c2cccc(C(F)(F)F)c2)n[nH]1>>CN(CCN1CCOCC1)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2C(=O)Nc2nc(-c3cccc(C(F)(F)F)c3)n[nH]2)c1,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US20160152609A1,CCOC(=O)c1nc(Br)n2c1CCc1cc(OC)c(CC(C)C)cc1-2.OB(O)c1ccsc1>>CCOC(=O)c1nc(-c2ccsc2)n2c1CCc1cc(OC)c(CC(C)C)cc1-2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20060247320A1,CC(C)[C@H](NC(=O)c1cc2cc3c(nc2s1)CCC(C(C)(C)C)C3)C(N)=O>>CC(C)[C@@H](C#N)NC(=O)c1cc2cc3c(nc2s1)CCC(C(C)(C)C)C3,,CCOC(C)=O,c1ccncc1,O=P(Cl)(Cl)Cl,,val
US20150274696A1,Nc1cc(F)c([N+](=O)[O-])cc1N.O=S(Cl)Cl>>O=[N+]([O-])c1cc2nsnc2cc1F,,ClCCl,,CCN(CC)CC,,val
US20110263673A1,COC(=O)c1c[nH]c(-c2ccc(F)cc2C(F)(F)F)c1C>>Cc1c(C(=O)O)c[nH]c1-c1ccc(F)cc1C(F)(F)F,,CCOC(C)=O,CO,Cl,[Na+].[OH-],val
US06350749B1,Cc1ccc2c(n1)CC(c1ccccc1)CC2=O.Cl.N=C(N)NN>>Cc1ccc2c(n1)CC(c1ccccc1)CC2=NNC(=N)N.Cl,,CCO,,Cl,O,val
US06174885B1,CCCCCCCCCCCCCCCCCCNC(=O)OCC1CC=CCC1C(=O)NCCN1CCCCC1.Cl>>CCCCCCCCCCCCCCCCCCNC(=O)OCC1CC=CCC1C(=O)NCCN1CCCCC1.Cl,,CCOC(C)=O,,,,val
US20110218192A1,CC(C)(C)N.N#Cc1cccc(-c2ccc3c(c2)C(CI)(N=C=S)CC(c2ccccc2)O3)c1>>CC(C)(C)NC1=NC2(CS1)CC(c1ccccc1)Oc1ccc(-c3cccc(C#N)c3)cc12,,ClC(Cl)Cl,,,,val
US20160264518A1,COC(=O)/C=C/c1ccccc1NCc1cccc(CCCO)c1.NO>>O=C(/C=C/c1ccccc1NCc1cccc(CCCO)c1)NO,,C1CCOC1,CO,[Na+].[OH-],,val
US20100137290A1,COc1ccc2ncc(F)c(CNCCCC3CN(c4ccc5c(c4)NC(=O)CS5)C(=O)O3)c2n1.OC[C@H]1CO1>>COc1ccc2ncc(F)c(CN(CCCC3CN(c4ccc5c(c4)NC(=O)CS5)C(=O)O3)C[C@@H](O)CO)c2n1,,C1CCOC1,CO,,,val
US20050250729A1,C1CCNCC1.CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1>>CC(=O)Nc1ccc(S(=O)(=O)N2CCCCC2)cc1,,C1COCCO1,,,,val
US20160007602A1,COC(=O)[C@@H](CCC(C)C)[C@H](C)O.COc1ccc(COC(=N)C(Cl)(Cl)Cl)cc1>>COC(=O)[C@@H](CCC(C)C)[C@H](C)OCc1ccc(OC)cc1,,ClCCl,,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US05665718,O=C1c2ccccc2C(=O)N1Cc1noc(-c2ncn3c2[C@@H]2CCN2C(=O)c2cc(F)ccc2-3)n1>>NCc1noc(-c2ncn3c2[C@@H]2CCN2C(=O)c2cc(F)ccc2-3)n1,,CCO,,CN,,val
US20100233116A1,Cc1cc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C1=NC(Cc2ccccc2)CN1>>Cc1cc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1-c1nc(Cc2ccccc2)c[nH]1,,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20130292665A1,Brc1c2ccccc2c(-c2ccc3ccc(-c4ccc5ccccc5c4)cc3c2)c2ccccc12.OB(O)c1ccccc1-c1ccccc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>c1ccc(-c2cccc(-c3c4ccccc4c(-c4ccc5ccc(-c6ccc7ccccc7c6)cc5c4)c4ccccc34)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US05073550,CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1cc(SCC2=C(C(=O)O)N3C[C@@H](NC(=O)/C(=N\OCS(=O)(=O)c4ccc(O)c(O)c4)c4csc(N)n4)[C@H]3SC2=O)n2nc(C(N)=O)nc2n1>>CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1cc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)/C(=N\OCS(=O)(=O)c4ccc(O)c(O)c4)c4csc(N)n4)[C@H]3SC2)n2nc(C(N)=O)nc2n1,,O,,,,val
US20140275027A1,Cc1ccc(S(=O)(=O)n2c(C3=CCN(S(C)(=O)=O)CC3)cc3c(Br)ccnc32)cc1>>CS(=O)(=O)N1CC=C(c2cc3c(Br)ccnc3[nH]2)CC1,,C1COCCO1,O,[Na+].[OH-],,val
US20140206681A1,CC1(C)OB(c2ccc(C(=O)O)cc2)OC1(C)C.Cn1nc(N)cc1C(F)(F)F>>Cn1nc(NC(=O)c2ccc(B(O)O)cc2)cc1C(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040039061A1,COC(=O)c1cccc(Cc2c(C)c(OC)c(OC)c(OC)c2OC)c1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1cccc(Cc2c(C)c(OC)c(OC)c(OC)c2OC)c1OS(=O)(=O)C(F)(F)F,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20110028509A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccc(C#N)cc1F>>COC(=O)c1ccc(CNC(=O)OC(C)(C)C)cc1F,[Pd],C1CCOC1,,,,val
US20090221555A1,CC(=O)Cl.O=[N+]([O-])c1ccc2c(c1)OCCCN2>>CC(=O)N1CCCOc2cc([N+](=O)[O-])ccc21,CN(C)c1ccncc1,c1ccncc1,,,,val
US20150361031A1,N#CCC(=O)Nc1ccc2c(c1)S(=O)(=O)C=C2.O=Cc1cccc(Br)n1>>N#CC(=Cc1cccc(Br)n1)C(=O)Nc1ccc2c(c1)S(=O)(=O)C=C2,,CCO,,C1CCNCC1,,val
US20060111375A1,CN1CCNCC1.COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1OCC1CO1>>COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1OCC(O)CN1CCN(C)CC1,,CN(C)C=O,,O,,val
US20100130506A1,COC(=O)CCc1ccc(OCc2ccncc2)cc1>>O=C(O)CCc1ccc(OCc2ccncc2)cc1,,C1CCOC1,CO,[Li+].[OH-],,val
US20100216810A1,CC(C)(C#N)c1cccc(C(=O)Nc2cccc(O)c2)c1.Nc1ccc(F)c([N+](=O)[O-])c1>>CC(C)(C#N)c1cccc(C(=O)Nc2cccc(Oc3ccc(N)cc3[N+](=O)[O-])c2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020198197A1,C1COCCN1.O=C1CC(c2cccc(-c3nc(CCl)cs3)c2)=Nc2ccc(-n3cccc3)cc2N1>>O=C1CC(c2cccc(-c3nc(CN4CCOCC4)cs3)c2)=Nc2ccc(-n3cccc3)cc2N1,,CO,O,[I-].[K+],,val
US20100331341A1,CN(C)C(=O)CCl.COc1cc(Br)c(O)c(C=O)c1>>COc1cc(Br)c2oc(C(=O)N(C)C)cc2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150045368A1,CC(C)(C)OC(=O)NC1CCC(=O)CC1.COC(=O)[C@@H](N)c1ccccc1>>COC(=O)[C@@H](NC1CCC(NC(=O)OC(C)(C)C)CC1)c1ccccc1,,ClCCCl,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100256188A1,CNc1cc(OCC(F)F)c(C(=O)O)cc1[N+](=O)[O-].Nc1ccc(Br)cc1>>CNc1cc(OCC(F)F)c(C(=O)Nc2ccc(Br)cc2)cc1[N+](=O)[O-],,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20030199573A1,CCOC(=O)C(Br)CC.O=c1cc(O)c2ccccc2o1>>CCOC(=O)C(CC)c1c(O)c2ccccc2oc1=O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20150376169A1,O=[N+]([O-])c1ccc(N2CCC2)cc1>>Nc1ccc(N2CCC2)cc1,[Pd],CCO,,,,val
US20120252805A1,BrBr.CCOC(=O)c1c(C)nc2sc(-c3cn[nH]c3)cc2c1NS(=O)(=O)c1cccc(Cl)c1>>CCOC(=O)c1c(C)nc2sc(-c3cn[nH]c3)c(Br)c2c1NS(=O)(=O)c1cccc(Cl)c1,,ClC(Cl)Cl,,,,val
US06121272,CCCCOc1ccc(S(=O)(=O)Cl)cc1.O=C(O)C1CCCCN1>>CCCCOc1ccc(S(=O)(=O)N2CCCCC2C(=O)O)cc1,CN(C)c1ccncc1,C1COCCO1,O,CCN(CC)CC,Cl,val
US20100056576A1,COC(=O)c1ccc(F)c(C2=CCC3(CC2)OCCO3)n1>>COC(=O)c1ccc(F)c(C2CCC3(CC2)OCCO3)n1,[Pd],CO,,,,val
US20040039064A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CO>>CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CO,,C1CCOC1,,,,val
US06610692B1,CCOC(C)=O.O=Cc1ccccn1>>CCOC(=O)/C=C/c1ccccn1,,C1CCOC1,O,[H-].[Na+],,val
US20040132727A1,COc1cc2nccc(Oc3ccc(N)c([N+](=O)[O-])c3)c2cc1OC.NCCN1CCCCC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)NCCN4CCCCC4)c([N+](=O)[O-])c3)c2cc1OC,,ClC(Cl)Cl,O,CCN(CC)CC,,val
US20100278733A1,CC(=O)c1ccc(I)cc1.O=Cc1ccccc1>>O=C(C=Cc1ccccc1)c1ccc(I)cc1,,CCO,,[K+].[OH-],,val
US08476434B2,O=[N+]([O-])c1cc(C(F)(F)F)ccc1F.OCCN1CCCC1>>Nc1cc(C(F)(F)F)ccc1OCCN1CCCC1,,C1CCOC1,,[H-].[Na+],,val
US20130158075A1,CC(C)(C)OC(=O)CC1CCC(C(=O)NCC(=O)c2ccc([N+](=O)[O-])cc2)CC1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)(C)OC(=O)CC1CCC(c2ncc(-c3ccc([N+](=O)[O-])cc3)s2)CC1,,C1COCCO1,,,,val
US20110112065A1,CC(C)N.CS(=O)(=O)c1ccc2c(c1)OC(CCl)OC2>>CC(C)NCC1OCc2ccc(S(C)(=O)=O)cc2O1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US05753678,ClCOc1ccccc1Br.O=C(O)C1CCN(CCCN2c3ccccc3OCOc3ccccc32)CC1>>O=CNc1ccccc1OCOc1ccccc1Br,,CCO,,Cl,C[O-].[Na+],val
US05360809,COc1cccc(-n2cnc3cc(C(F)(F)F)ccc32)c1>>Oc1cccc(-n2cnc3cc(C(F)(F)F)ccc32)c1,,ClCCl,,BrB(Br)Br,,val
US20120022053A1,C1COCCO1.C=O.CNC(=N)N[N+](=O)[O-]>>CN1COCN=C1N[N+](=O)[O-],,Cc1ccccc1,,CCN(CC)CC,,val
US20120040949A1,CC(=O)OCc1c(-c2cc(Nc3ccc(N4CC5(CN(C(=O)OC(C)(C)C)C5)C4)cn3)c(=O)n(C)n2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O>>Cn1nc(-c2cccc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(Nc2ccc(N3CC4(CN(C(=O)OC(C)(C)C)C4)C3)cn2)c1=O,,C1COCCO1,,[Li+].[OH-],,val
US20130116243A1,COC(=O)C1(C)CCc2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc2C1=O.NN>>CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)C3=NNC(=O)C3(C)CC4)cc2)CCC1,,CCO,,O,,val
US20030004193A1,CCOC(OCC)OCC.Cc1cc(I)ccc1Nc1c(C(=O)NN)ccc(F)c1F>>Cc1cc(I)ccc1Nc1c(-c2nnco2)ccc(F)c1F,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100063101A1,N#Cc1ccc(NCC(C2CCCCC2)n2c(-c3ccc(Cl)cc3)nc3cc(F)c(F)cc32)cc1.[N-]=[N+]=[N-]>>Fc1cc2nc(-c3ccc(Cl)cc3)n(C(CNc3ccc(-c4nnn[nH]4)cc3)C3CCCCC3)c2cc1F,,Cc1ccccc1C,,CCN(CC)CC,Cl,val
US20140275129A1,BrCc1ccccc1.COc1ccc2c(c1O)CCNC2=O>>COc1ccc2c(c1OCc1ccccc1)CCNC2=O,,CCO,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100135999A1,CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(O)c3ccccc3c2)CC1.O=C(NC1CC1)[C@@H]1CCCN1C(=O)CBr>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)O)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CC3)c3ccccc3c2)CC1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100105700A1,CCCC[Sn](CCCC)(CCCC)c1cnccn1.C[C@]12CCC(=O)NC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(I)=CC[C@@H]12>>C[C@]12CCC(=O)NC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3cnccn3)=CC[C@@H]12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20140045790A1,C[C@@H](COc1ccc(F)cc1C(F)(F)F)NCCO[Si](C)(C)C(C)(C)C.Cl>>C[C@@H](COc1ccc(F)cc1C(F)(F)F)NCCO.Cl,,CO,,,,val
US05001144,CCOC(=O)Cl.Cc1cc(C2=C(/C=C/C(O)CC(O)CC(=O)O)C(C)(C)CC3(C2)SCCCS3)ccc1F>>COC(=O)C1C(c2ccc(F)c(C)c2)=CCCC1(C)C,,CCOCC,ClCCl,CCN(CC)CC,,val
US20070135595A1,CC1Cc2c(Br)cc(Cl)cc2C1=O>>CC1=Cc2cccc(Br)c2C1,,C1CCOC1,CO,Cl,[BH4-].[Na+],val
US20120046292A1,COC(=O)c1ccc(C2CCC(=CC(=O)OC(C)(C)C)CC2)cc1>>COC(=O)c1ccc(C2CCC(CC(=O)O)CC2)cc1,[Pd],C1CCOC1,,CO,,val
US20060030559A1,CI.Cc1nc(C#Cc2ccnc(Cl)c2)cn1-c1ccc(F)cc1>>Cc1nc(C#Cc2ccnc(Cl)c2)c(C)n1-c1ccc(F)cc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20090143372A1,CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(B4OC(C)(C)C(C)(C)O4)cc23)CC1.O=Cc1cc(Br)co1>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4coc(C=O)c4)cc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20120115844A1,CC(C)N.Cn1nnc(-c2ccc(F)cn2)c1COc1ccc(C(=O)O)nc1>>CC(C)NC(=O)c1ccc(OCc2c(-c3ccc(F)cn3)nnn2C)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20160229814A1,CCn1c(=O)n(CC2COC2)c(=O)c2cc([N+](=O)[O-])ccc21>>CCn1c(=O)n(CC2COC2)c(=O)c2cc(N)ccc21,[Pd],CO,,[H][H],,val
US06136823,CCOC(=O)c1cn(-c2cc(OC)c(F)cc2F)c2c(C)c(N)c(F)cc2c1=O>>Cc1c(N)c(F)cc2c(=O)c(C(=O)O)cn(-c3cc(O)c(F)cc3F)c12,,CC(=O)O,,Br,,val
US20150191450A1,COC(=O)c1cccc2c[n+]([O-])ccc12.O=P(Cl)(Cl)Cl>>COC(=O)c1cccc2c(Cl)nccc12,,ClCCl,,,,val
US20030009028A1,CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)C[C@@H]1O.COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1>>COc1ccc(C(O[C@H]2C[C@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)O[C@@H]2CO[Si](C)(C)C(C)(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1,,c1ccncc1,,O=C([O-])O.[Na+],,val
US20100076199A1,CCCN.CO.Cc1occc(=O)c1OCc1ccccc1>>COCCn1ccc(=O)c(OCc2ccccc2)c1C,,CCOC(C)=O,,[Na+].[OH-],,val
US05405851,C[Si](C)(C)C#Cc1ccc2c(c1)CC1(CC2)OCCO1>>C#Cc1ccc2c(c1)CC1(CC2)OCCO1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20110003784A1,C[C@H]1CCCC(C)(C)[C@@H]1/C=C/C(=O)N1CCN(C(N)=O)CC1>>C[C@H]1CCCC(C)(C)[C@@H]1CCC(=O)N1CCN(C(N)=O)CC1,[Pd],CO,,,,val
US20070225332A1,CC(C)Oc1ccc(Oc2ncc(C=O)s2)cc1.NO>>CC(C)Oc1ccc(Oc2ncc(C=NO)s2)cc1,,O,,Cl,c1ccncc1,val
US06117841,CC(C)C[C@@H](C(=O)OC(C)(C)C)N(C)Cc1ccc(C(C)(C)C)cc1>>CC(C)C[C@@H](C(=O)O)N(C)Cc1ccc(C(C)(C)C)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04563455,Nc1ccccc1Nc1ccccc1.O=C(O)Cc1cccnc1>>c1ccc(-n2c(Cc3cccnc3)nc3ccccc32)cc1,,ClC(Cl)Cl,,O=P(Cl)(Cl)Cl,,val
US20110053940A1,CC(C)(C)OC(=O)N(Cc1cc(Br)cc(C=O)c1)C1CC1.COC/C=C/B1OC(C)(C)C(C)(C)O1>>COC/C=C/c1cc(C=O)cc(CN(C(=O)OC(C)(C)C)C2CC2)c1,,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US04560691,CN(C)C(OC(C)(C)C)N(C)C.Cc1[nH]c(=O)ccc1C(=O)c1ccc(Br)cc1>>CN(C)C=Cc1[nH]c(=O)ccc1C(=O)c1ccc(Br)cc1,,C1COCCO1,,,,val
US05534518,N#Cc1c(N)ccc(Br)c1Cl.OB(O)c1cc(Cl)cc(Cl)c1>>N#Cc1c(N)ccc(-c2cc(Cl)cc(Cl)c2)c1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20070149546A1,CC(=O)CCl.Oc1cccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12>>CC(=O)COc1cccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150329547A1,CC(C)Oc1ccc(-c2cc(Cl)cc(Cl)n2)cc1.c1cn[nH]c1>>CC(C)Oc1ccc(-c2cc(-n3cccn3)cc(Cl)n2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100016319A1,C1COCCN1.Cc1coc(NC(=O)NCc2ccccc2Oc2ccnc(Cl)n2)n1>>Cc1coc(NC(=O)NCc2ccccc2Oc2ccnc(N3CCOCC3)n2)n1,,CCO,,,,val
US05587486,C=CC(=O)OC.COC(=O)Cl.Cc1ccsc1C=Nc1ccccc1>>COC(=O)C1CCc2ccsc2C1N(C(=O)OC)c1ccccc1,,Cc1ccccc1C,,CCN(C(C)C)C(C)C,,val
US20100029722A1,CCCCOC(=O)c1sc(-c2n[nH]c(Cc3ccccc3)n2)cc1C>>Cc1cc(-c2n[nH]c(Cc3ccccc3)n2)sc1C(=O)O,,CCO,O,CC(=O)O,[Na+].[OH-],val
US20130109678A1,Nc1ccc(-c2nc3cc(NN4CCOCC4)ccc3[nH]2)cc1[N+](=O)[O-]>>Nc1ccc(-c2nc3cc(NN4CCOCC4)ccc3[nH]2)cc1N,[Pd],CCOC(C)=O,CO,,,val
US20090137561A1,CC(C)(C)[Si](C)(C)Cl.Oc1ccccc1F>>CC(C)(C)[Si](C)(C)Oc1ccccc1F,,CN(C)C=O,,c1c[nH]cn1,,val
US20110288093A1,Clc1ccc(I)nn1.OCCc1ccc(Cl)cc1>>Clc1ccc(CCOc2ccc(I)nn2)cc1,,C1CCOC1,,[H-].[Na+],,val
US20110245303A1,CCOC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CBr)c1.Oc1ccccc1>>CCOC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2COc2ccccc2)c1,,C1COCCO1,,[H-].[Na+],,val
US20070004713A1,Nc1ccc(O)cc1[N+](=O)[O-].O=C(O)c1ccccc1C(=O)O>>O=C1c2ccccc2C(=O)N1c1ccc(O)cc1[N+](=O)[O-],,CC(=O)O,,,,val
US20060247179A1,COc1cccc2c1C(=O)CS2.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1cccc2scc(OS(=O)(=O)C(F)(F)F)c12,,ClCCl,,CCN(CC)CC,Cl,val
US20020035266A1,COC(=O)/C(=C/C1CCCCC1)c1ccc(-n2nnnc2C(F)(F)F)c(Cl)c1>>O=C(O)/C(=C/C1CCCCC1)c1ccc(-n2nnnc2C(F)(F)F)c(Cl)c1,,CCO,,[Na+].[OH-],,val
US20100152441A1,COc1ccc2ncc(=O)n(C(C)CN3CCC(NC(=O)OC(C)(C)C)CC3)c2c1>>COc1ccc2ncc(=O)n(C(C)CN3CCC(N)CC3)c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160184318A1,CS(=O)(=O)Cl.Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCC(CO)CC2)n1>>Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCC(COS(C)(=O)=O)CC2)n1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US04267174,N#CC1CN1.O=C(Cl)C(c1ccccc1)c1ccccc1>>N#CC1CN1C(=O)C(c1ccccc1)c1ccccc1,,CCOCC,,CCN(CC)CC,,val
US04935437,CC(C)(O)c1cc(Cn2cncn2)cc(C(C)(C)C#N)c1>>CC(C)c1cc(Cn2cncn2)cc(C(C)(C)C#N)c1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20060247287A1,CC(C)C(NC(=O)OC(C)(C)C)C(=O)CCN(C(=O)C(Cl)Cl)c1ccnc(-c2cc(-c3c(Cl)cccc3Cl)no2)c1>>CC(C)C(N)C(=O)CCN(C(=O)C(Cl)Cl)c1ccnc(-c2cc(-c3c(Cl)cccc3Cl)no2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110112075A1,CN1CCN(C(=O)[C@@H](N)CNC(=O)c2ccc(Cl)s2)CC1.Cc1nc(-c2ccc(S(=O)(=O)Cl)cc2)cs1.Cl>>Cc1nc(-c2ccc(S(=O)(=O)N[C@@H](CNC(=O)c3ccc(Cl)s3)C(=O)N3CCN(C)CC3)cc2)cs1.Cl,,ClCCl,,Cl,,val
US20080318922A1,COC(=O)c1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)n(Cc2cc(F)ccc2Cl)c2c(=O)n(Cc3ccc(OC)cc3)c(=O)n(C)c12>>COC(=O)c1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)n(Cc2cc(F)ccc2Cl)c2c(=O)[nH]c(=O)n(C)c12,,COc1ccccc1,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20020007059A1,CCOC(=O)C1=C(COC(C)=O)Nc2c(c(=O)[nH]n2C)C1c1ccc(F)c(Br)c1>>Cn1[nH]c(=O)c2c1NC1=C(C(=O)OC1)C2c1ccc(F)c(Br)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US03940418,COC(=O)c1nn(-c2ccccc2)c2c1CCc1cc(Cl)ccc1-2>>O=C(O)c1nn(-c2ccccc2)c2c1CCc1cc(Cl)ccc1-2,,CO,,Cl,[Na+].[OH-],val
US20090275588A1,CCN.Cc1cc(CCl)on1>>CCNCc1cc(C)no1,,C1CCOC1,,,,val
US20140349991A1,BrCCOC1CCCCO1.Cc1c([C@H]2CCCN2)oc2c(C)c(O)ccc2c1=O>>Cc1c([C@H]2CCCN2CCOC2CCCCO2)oc2c(C)c(O)ccc2c1=O,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20050027129A1,COc1ccc(C(=O)Nc2cccnc2)c2c1oc1ccc([N+](=O)[O-])cc12>>COc1ccc(C(=O)Nc2cccnc2)c2c1oc1ccc(N)cc12,[Ni],CO,,NN,O,val
US05180418,COC(=O)C1(Sc2cc(NC(=S)N3CCCCN3)c(F)cc2Cl)CCC1.O=C(Cl)Cl>>COC(=O)C1(Sc2cc(N=c3sc(=O)n4n3CCCC4)c(F)cc2Cl)CCC1,,Cc1ccccc1,,CCN(CC)CC,,val
US03932663,Clc1ccccc1.O=C(Cl)c1ccc(-c2ccc(Cl)cc2)cc1>>O=C(c1ccc(Cl)cc1)c1ccc(-c2ccc(Cl)cc2)cc1,,Clc1ccccc1,,,,val
US20140249120A1,COCO[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)[C@@H](COCc5ccccc5)CC[C@H]4[C@@H]3C[C@@H](OC)[C@H]2C1>>CO[C@@H]1C[C@H]2[C@@H]3CC[C@H](COCc4ccccc4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@H](O)C[C@H]12,,CO,,Cl,O=C([O-])O.[Na+],val
US06576676B1,CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC1O>>CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC1=O,,CCOCC,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20120157387A1,CC(C)(C)OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC[C@@H](NC(=O)OCc1ccccc1)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)[C@H](N)CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C,[Pd],CCO,,[H][H],,val
US20130225589A1,C=CCN.CCOC(=O)/C(=C\N(C)C)c1nc(SC)ncc1C(=O)OCC>>C=CCn1cc(C(=O)OCC)c2nc(SC)ncc2c1=O,,CCO,,Cl,ClCCl,val
US20100130492A1,CS(=O)(=O)C1CCNCC1.Nc1ncc(-c2nc(N3CCOCC3)c3nc(Cl)n(CC(F)(F)F)c3n2)cn1>>CS(=O)(=O)C1CCN(c2nc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3n2CC(F)(F)F)CC1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,Cl,val
US04920133,O=C(O)c1ccc(CCc2ccc(S(=O)Cc3ccc4ccccc4n3)cc2)cc1.OO>>O=C(O)c1ccc(CCc2ccc(S(=O)(=O)Cc3ccc4ccccc4n3)cc2)cc1,,ClCCl,,CC(=O)O,,val
US20140343032A1,COC(=O)C12CC(F)(CN1C)C2>>O=C(O)C12CC(F)(CN1)C2,,ClCCl,,Cl,,val
US05679623,CCC(=O)CBr.Cc1cn(N=Cc2cccnc2)c(=O)[nH]1>>CCC(=O)Cn1c(C)cn(N=Cc2cccnc2)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20120149910A1,CCOC(=O)Cl.CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1ccc(-n2cncn2)c(N)c1>>CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1ccc(-n2cncn2)c(NC(=O)OC)c1,,C1CCOC1,O,c1ccncc1,,val
US04663329,CCOC(=O)c1cn(CC)c2sc(C=O)cc2c1=O.NO>>CCOC(=O)c1cn(CC)c2sc(C=NO)cc2c1=O,,CCO,,Cl,[Na+].[OH-],val
US06420424B1,CCOC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)OC(C)(C)C.CS(=O)(=O)Cl.c1ccncc1>>CCOC(=O)[C@H](Cc1ccc(NS(=O)(=O)CN)cc1)NC(=O)OC(C)(C)C,,ClCCl,,,,val
US06686353B1,Oc1cccc(C(O)(CCN2CCCNCC2)c2ccccc2)c1>>Oc1cccc(C(=CCN2CCCNCC2)c2ccccc2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100112701A1,CCOC(=O)C(=O)c1ccccc1COC.CN>>CNC(=O)C(=O)c1ccccc1COC,,Cc1ccccc1,O,CO,,val
US20050165003A1,COc1cc(C=O)ccc1O.CS(=O)(=O)CCc1ccccn1>>COc1cc(C=O)ccc1CCc1ccccn1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05244597,COc1ccc(CC[C@@H]2CC[C@@H](O)CC2)cc1>>Oc1ccc(CC[C@@H]2CC[C@@H](O)CC2)cc1,,ClCCl,,BrB(Br)Br,,val
US20160015712A1,CCCCON=O.Nc1cnc(Cl)nc1Nc1ccc(Br)cc1>>Clc1ncc2nnn(-c3ccc(Br)cc3)c2n1,,CC#N,,,,val
US05182283,CCCCCS.CN1CCCC(O)(c2nccnc2Cl)C1.O=S(Cl)Cl>>CCCCCSc1nccnc1C1=CCCN(C)C1.Cl,,C1CCOC1,,[H-].[Na+],,val
US05484685,CCCCSc1ccc2cc(C#N)c(C#N)cc2c1.N>>CCCCSc1ccc2cc3c(cc2c1)C(=N)NC3=N,,CO,,[Na],C[O-].[Na+],val
US20140296183A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCCCCOc1ccc(CCC(N)(CC)CO)cc1C(F)(F)F>>CCCCCCCOc1ccc(CCC(CC)(CO)NC(=O)OC(C)(C)C)cc1C(F)(F)F,,CO,,CCN(C(C)C)C(C)C,Cl,val
US20080221192A1,CCOC(=O)Cc1cccc(Nc2cccc(N)c2)c1N>>Nc1cccc(Nc2cccc3c2NC(=O)C3)c1,,Cl,,O=C([O-])[O-].[Na+].[Na+],,val
US20100184649A1,CCCCCCCCCC(C)C(=O)O.O=C(Cl)C(=O)Cl>>CCCCCCCCCC(C)C(=O)Cl,,ClCCl,,CN(C)C=O,,val
US20160002215A1,O=[N+]([O-])c1cc(-c2nn[nH]n2)cc(C(F)(F)F)c1>>Nc1cc(-c2nn[nH]n2)cc(C(F)(F)F)c1,[Pd],CO,,,,val
US20130053409A1,C=CC(=O)Cl.COc1cc(N2CC[C@@H]3CN(C)C[C@@H]32)c(N)cc1Nc1nccc(-c2cn(C)c3ccccc23)n1>>C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N1CC[C@@H]2CN(C)C[C@@H]21,,C1CCOC1,ClCCl,,,val
US20150232445A1,CCOC(CC#N)OCC.NNC1CC1>>Nc1ccnn1C1CC1,,CCO,,Cl,Cl,val
US20080234255A1,CCOC(=O)C(C)CNC1CCCC1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>CCOC(=O)CC(C)N(c1nc(Cl)ncc1[N+](=O)[O-])C1CCCC1,,CCOCC,O,O=C([O-])O.[K+],,val
US20100292253A1,CSCC(C)C(=O)Nc1sc(-c2cncc(F)c2)nc1C.N#CN.O=C([O-])Cc1cccc(I)c1CC(=O)[O-]>>Cc1nc(-c2cncc(F)c2)sc1NC(=O)C(C)CS(C)(=O)=NC#N,,ClCCl,,,,val
US20120220550A1,CCOC(=O)CC(=O)c1ccc(I)cc1.NNc1ncccn1>>Oc1cc(-c2ccc(I)cc2)nn1-c1ncccn1,,CCO,,,,val
US20130324528A1,CNC(=O)CBr.Cc1ccc(F)c(-c2cc(Nc3ccnc4cn[nH]c34)c(C)cn2)n1>>CNC(=O)Cn1ncc2nccc(Nc3cc(-c4nc(C)ccc4F)ncc3C)c21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090176841A1,CC(C)c1cc(Cn2ccc3c(C(=O)O)cccc32)ccc1OCc1ccccc1.O=C(Cl)C(=O)Cl>>CC(C)c1cc(Cn2ccc3c(C(=O)Cl)cccc32)ccc1OCc1ccccc1,,ClCCl,,,,val
US20060252931A1,COC(=O)[C@H](CC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1)Cc1cc(Cl)c(O)c(C(F)(F)F)c1>>O=C(O)[C@H](CC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1)Cc1cc(Cl)c(O)c(C(F)(F)F)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20100267768A1,COC(=O)C(C)(C)c1cc(C(C)(C)C)c([N+](=O)[O-])cc1O>>CC(C)(C)c1cc(C(C)(C)CO)c(O)cc1[N+](=O)[O-],,C1CCOC1,CO,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US04407813,FC(F)Oc1ccc(C2=NNCC2c2ccccc2)cc1.S=C=Nc1ccc(Cl)cc1>>FC(F)Oc1ccc(C2=NN(C(=S)Nc3ccc(Cl)cc3)CC2c2ccccc2)cc1,,CCOCC,,,,val
US20090270350A1,COc1ccc(Cn2c(C)cc(OCc3ccccc3CNC(=O)Nc3cc(C(C)(C)C)nn3-c3cccc(OCCOC4CCCCO4)c3)c(Cl)c2=O)cc1>>COc1ccc(Cn2c(C)cc(OCc3ccccc3CNC(=O)Nc3cc(C(C)(C)C)nn3-c3cccc(OCCO)c3)c(Cl)c2=O)cc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05055567,O=C(Cl)CCCl.O=C1NCCCN1>>NC(=O)NC(=O)CCCl,,Cc1ccccc1,,CCN(CC)CC,,val
US20110275611A1,CC(C)[C@@H]1COCCN1.Nc1nc(Cl)cc(Cl)n1>>CC(C)[C@@H]1COCCN1c1cc(Cl)nc(N)n1,,CCC#N,,CCN(C(C)C)C(C)C,Cl,val
US20080139610A1,Cc1cc(Br)cc(Cl)c1NC(=O)CC(C)(C)C.Fc1ccc2c(c1)CNCC2>>Cc1cc(N2CCc3ccc(F)cc3C2)cc(Cl)c1NC(=O)CC(C)(C)C,,Cc1ccccc1,,Cl,CC(C)(C)[O-].[K+],val
US20140275130A1,CC(C)(C)OC(=O)Nc1cnccc1B(O)O.Cn1cncc1Br>>Cn1cncc1-c1ccncc1N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20020013310A1,COc1ccc2ccc(S(=O)(=O)Cl)cc2c1.Nc1ccc(CCN2CC[C@H](N)C2=O)cc1[N+](=O)[O-]>>COc1ccc2ccc(S(=O)(=O)N[C@H]3CCN(CCc4ccc(N)c([N+](=O)[O-])c4)C3=O)cc2c1,,ClCCl,,,,val
US20110237590A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.NC(=O)Cc1cnc(Nc2ccc(N)cc2)cc1NCc1ccccc1>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(Nc3cc(NCc4ccccc4)c(CC(N)=O)cn3)cc2)CC1,,C1CCOC1,Cc1ccccc1,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20070072920A1,CC(C)(C)OC(=O)OC(=O)[O-].COc1cc(C)c(OCc2ccccc2)cc1CC(C)N>>COc1cc(C)c(O)cc1CC(C)NC(=O)OC(C)(C)C,,Cl,ClCCl,,,val
US20040106667A1,CC(C)(C)OC(=O)N(c1ccc2c(c1)c(I)nn2C(=O)OC(C)(C)C)S(=O)(=O)c1ccccc1S(C)(=O)=O.OB(O)c1cccs1>>CS(=O)(=O)c1ccccc1S(=O)(=O)Nc1ccc2[nH]nc(-c3cccs3)c2c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20130338142A1,Brc1cn2ccnc2c(Br)n1.COc1cc(N)ccc1N1CCN(C2COC2)CC1>>COc1cc(Nc2nc(Br)cn3ccnc23)ccc1N1CCN(C2COC2)CC1,,CC(C)O,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20060142366A1,CC(C)(C)O.O=C(O)c1cc2ccccc2[nH]1>>CC(C)(C)OC(=O)c1cc2ccccc2[nH]1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20050107288A1,C[C@H](NC(=O)[C@@H]1CCCCN1C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(=O)OCc1ccccc1>>C[C@H](NC(=O)[C@@H]1CCCCN1C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(=O)O,[Pd],CO,,[H][H],,val
US20020025960A1,CCOC(=O)c1cnc2ccc(I)cn2c1=O.NCc1ccc(Cl)cc1>>O=C(NCc1ccc(Cl)cc1)c1cnc2ccc(I)cn2c1=O,,Cc1ccccc1,O,C[Al](C)C,Cl,val
US20040162296A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CSC(=N)NC(=O)c1nc(Cl)c(N)nc1N>>CSC(=NC(=O)c1nc(Cl)c(N)nc1N)NC(=O)OC(C)(C)C,CN(C)c1ccncc1,C1CCOC1,CCN(CC)CC,I,,val
US05422335,CCCCN=C=O.N#Cc1c(N)sc2c1CCCC2>>CCCCNC(=O)Nc1sc2c(c1C#N)CCCC2,,Cc1ccccc1,,CCN(CC)CC,,val
US20140296069A1,CSc1cc(C)cc(C(=O)O)c1N.Cl[Cu]>>CSc1cc(C)cc(C(=O)O)c1Cl,Cl[Cu],O,,Cl,O=N[O-].[Na+],val
US20090298744A1,CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CNC(C(=O)OC)C4)cc3)nc2n(CCC)c1=O.FC(F)(F)c1cccc(CBr)c1>>CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(C(=O)OC)N(Cc5cccc(C(F)(F)F)c5)C4)cc3)nc2n(CCC)c1=O,,ClCCl,,O,,val
US20100158996A1,BrCCOCc1ccccc1.CCOC(=O)C(C(=O)OCC)c1ccccc1>>CCOC(=O)C(CCOCc1ccccc1)(C(=O)OCC)c1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US20150315198A1,CCOC(=O)C(CN)C(=O)OCC.CCOC=C(C#N)C#N>>CCOC(=O)c1[nH]cc(C#N)c1N,,CCO,,Cl,[Na],val
US20150148377A1,CC(=O)Oc1ccc([N+](=O)[O-])cc1F>>CC(=O)Oc1ccc(N)cc1F,[Ni],CO,,,,val
US20100009964A1,Cc1nc(N)sc1C(C)(C)C.O=C(C1CCOCC1)N1CCCNCC1.O=C(Cl)OCC(Cl)(Cl)Cl>>Cc1nc(NC(=O)N2CCCN(C(=O)C3CCOCC3)CC2)sc1C(C)(C)C,,ClCCCl,ClCCl,CCN(C(C)C)C(C)C,,val
US20160031903A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)CC(N)C(F)(F)F>>CCOC(=O)CC(NC(=O)OC(C)(C)C)C(F)(F)F,,C1CCOC1,,CCN(CC)CC,Cl,val
US20100168075A1,CC(C)(C)OC(=O)N[C@H](CCCCN)C(=O)O.O=C(O)CNC(=O)COc1ccc([C@@H]2[C@@H](SCC(=O)c3ccc(F)cc3)C(=O)N2c2ccc(F)cc2)cc1>>N[C@H](CCCCNC(=O)CNC(=O)COc1ccc([C@@H]2[C@@H](SCC(O)c3ccc(F)cc3)C(=O)N2c2ccc(F)cc2)cc1)C(=O)O,,ClCCl,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US04406828,CC1(C)CCC(C(=O)Cl)c2ccccc21.CCBr>>CCC(=O)C1CCC(C)(C)c2ccccc21,[Cu]I,CCOCC,,[Mg],,val
US20110028455A1,CCc1ncc(C#N)c(Cl)c1Br.Cc1c(N)ccc2[nH]ccc12>>CCc1ncc(C#N)c(Nc2ccc3[nH]ccc3c2C)c1Br,,CCO,,O,,val
US20110130377A1,COCCl.OCc1coc(-c2ccc(Cl)cc2)n1>>COCOCc1coc(-c2ccc(Cl)cc2)n1,,C1CCOC1,,O,[H-].[Na+],val
US20060111375A1,COc1cc2nccc(Oc3ccc(C)nc3I)c2cc1OC.OB(O)c1ccc(O)cc1>>COc1cc2nccc(Oc3ccc(C)nc3-c3ccc(O)cc3)c2cc1OC,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070185096A1,C=CS(=O)(=O)C=C.Nc1ccc(Cl)c(C(=O)O)c1>>O=C(O)c1cc(N2CCS(=O)(=O)CC2)ccc1Cl,,O,,,,val
US20140011800A1,CC[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12>>CC[C@@H]1CNCC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130281657A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)NCCCNc1ncc(C=O)s1>>C[C@H](N)C(=O)NCCCNc1ncc(C=O)s1,,ClCCl,,CCOCC,Cl,val
US20110130417A1,CCN.O=C(O)CN1CCC2(CC1)CCN(c1ccc(C3CC3)cc1)C2=O>>CCNC(=O)CN1CCC2(CC1)CCN(c1ccc(C3CC3)cc1)C2=O,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20150239861A1,CCNC(=O)CC[C@H](N)C(=O)OCC.O=C(O)c1cc2cc(Br)ccc2oc1=O>>CCNC(=O)CC[C@H](NC(=O)c1cc2cc(Br)ccc2oc1=O)C(=O)OCC,,ClCCl,,CCN(C(C)C)C(C)C,CCN=C=NCCCN(C)C,val
US20020198196A1,CC1=C(c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2C)CCCC1O>>CC1=C(c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2C)CCC[C@@H]1O,,CCCCCC,,CCO,,val
US20080033001A1,CC(=O)OC(C)=O.COc1ccnc2c1cc1ccnc(N)n12>>COc1ccnc2c1cc1ccnc(NC(C)=O)n12,,C1CCOC1,,,,val
US05780634,COC(=O)c1ccccc1-c1cc(C(=O)OC)c2cc(C)ccc2n1>>COC(=O)c1ccccc1-c1cc(C(=O)O)c2cc(C)ccc2n1,,CO,,O,[Na+].[OH-],val
US20090264420A1,CS(=O)(=O)Cl.OCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CS(=O)(=O)OCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,,ClCCl,,CCN(CC)CC,,val
US20010020095A1,Clc1ccc2c(ccn2-c2ccncc2)c1.ICCC1Cc2ccccc2C1>>Clc1ccc2c(ccn2C2=CCN(CCC3Cc4ccccc4C3)CC2)c1,,CC(=O)CC(C)C,,,,val
US07427626B2,CC(C)n1c(-c2ccnc(Nc3ccccc3)n2)cnc1C=O.CON>>CON=Cc1ncc(-c2ccnc(Nc3ccccc3)n2)n1C(C)C,,CCO,,Cl,c1ccncc1,val
US20160039745A1,COC(=O)[C@]1(c2cccc(F)c2C)C=C(c2nc3c(Br)cccc3s2)CC1>>COC(=O)[C@@]1(c2cccc(F)c2C)CCC(c2nc3ccccc3s2)C1,[Pd],CCO,,[H][H],,val
US20050197362A1,CCN=C=O.O=C(CCCCCl)c1ccc2c(c1)CCNCC2>>CCNC(=O)N1CCc2ccc(C(=O)CCCCCl)cc2CC1,,C1CCOC1,,O,,val
US20050143443A1,CCOC(=O)c1ccc[nH]1.O=C(Cl)CCC1CCCC1>>CCOC(=O)c1cc(C(=O)CCC2CCCC2)c[nH]1,,CC(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20040116465A1,CCOc1ccc(C(=O)c2nc3cc(C(=O)N(CC)CC)ccc3n2CCC(C)C)cc1>>CCOc1ccc(C(O)c2nc3cc(C(=O)N(CC)CC)ccc3n2CCC(C)C)cc1,,CCO,,[BH4-].[Na+],,val
US20090036503A1,CNC(=O)C12CCC(C(=O)OC)(CC1)CC2.FC(F)(F)c1ccccc1-c1nnn[nH]1>>COC(=O)C12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20090029947A1,COCCCCCCc1ccc([C@@H]2CC[C@](N)(C(=O)OC)C2)cc1.Cl>>COCCCCCCc1ccc([C@@H]2CC[C@](N)(CO)C2)cc1.Cl.O,,CCO,,[BH4-].[Na+],,val
US04695575,CCN(CC)CC.Fc1ccc(Cn2c(CC3CCN(CCNc4ccccn4)CC3)nc3ccccc32)cc1.O=C(Cl)c1ccccc1>>O=C(c1ccccc1)N(CCN1CCC(Cc2nc3ccccc3n2Cc2ccc(F)cc2)CC1)c1ncccn1,,C1CCOC1,,,,val
US20090062366A1,CC(=O)c1c(Cl)n(C)c2ccccc12.Oc1ccccc1>>CC(=O)c1c(Oc2ccccc2)n(C)c2ccccc12,,CC(=O)N(C)C,,[H-].[Na+],,val
US20100137313A1,CC(=O)c1cccc(S(N)(=O)=O)c1.COc1cc(Nc2ncc(-c3cnc(OC)c(C(=O)O)c3)c(-n3nc(C(F)(F)F)cc3C)n2)cc(OC)c1>>COc1cc(Nc2ncc(-c3cnc(OC)c(C(=O)NS(=O)(=O)c4cccc(C(C)=O)c4)c3)c(-n3nc(C(F)(F)F)cc3C)n2)cc(OC)c1,CN(C)c1ccncc1,ClCCl,ClCCl,CCN(CC)CC,C[n+]1ccccc1Cl.[I-],val
US20030105081A1,CNCc1ccccc1.COC(OC)c1ncccc1C=O>>COC(OC)c1ncccc1CN(C)Cc1ccccc1,,CC(Cl)Cl,O,[Na+].[OH-],,val
US20120077781A1,CCOC(=O)C(C)(C)CCCCCNc1cc(C)c(C)cc1[N+](=O)[O-]>>CCOC(=O)C(C)(C)CCCCCNc1cc(C)c(C)cc1N,[Pd],CO,,[BH4-].[Na+],,val
US20040121965A1,CCC[C@@H](/C=C(\C)C(=O)OCC)N(CC)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)OC(C)(C)C)C(C)(C)c1ccccc1)C(C)(C)C>>CCC[C@@H](/C=C(\C)C(=O)OCC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)(C)c1ccccc1)C(C)(C)C,,ClCCl,O=C(O)C(F)(F)F,,,val
US03939157,CC(C)(C)OC(=O)C(N1C(=O)C(NC(c2ccccc2)(c2ccccc2)c2ccccc2)C1SCC(=O)Cc1ccc(F)cc1)=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)C1=C(Cc2ccc(F)cc2)CS[C@@H]2C(NC(c3ccccc3)(c3ccccc3)c3ccccc3)C(=O)N12,,C1COCCO1,,,,val
US20120122842A1,CC(C)(C)OC(=O)NCC1CNC1.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)NCC1CN(c2ccc([N+](=O)[O-])cc2)C1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06004977,COC=Cc1cc(OC)ccc1F.Cl.NNc1ccncc1>>COc1ccc(F)c(CC=NNc2ccncc2)c1.Cl,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20040267015A1,COC(=O)Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1.NO>>O=C(Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1)NO,,C1COCCO1,,,,val
US06936602B1,CCOCCN(CC)c1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3C=O)cc1>>CCOCCN(CC)c1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCN3C=O)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20030215959A1,O=[N+]([O-])O.[N-]=[N+]=Nc1ccc2nc(O)c(O)nc2c1>>[N-]=[N+]=Nc1cc2nc(O)c(O)nc2cc1[N+](=O)[O-],,CC(=O)O,,,,val
US20120077828A1,Nc1ncc(I)c2scc(-c3ccc4c(c3)CCN4C(=O)Cc3cc(F)ccc3F)c12.OB(O)c1cc[nH]n1>>Nc1ncc(-c2cc[nH]n2)c2scc(-c3ccc4c(c3)CCN4C(=O)Cc3cc(F)ccc3F)c12,,CCOC(C)=O,O,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20060128732A1,CC(=O)OC(C)=O.Nc1ccc(C(=O)O)cn1>>CC(=O)Nc1ccc(C(=O)O)cn1,,c1ccncc1,,CCOC(C)=O,Cl,val
US05736487,COC(=O)Cl.Nc1ccc(OCc2nc3ccccc3s2)cc1>>COC(=O)Nc1ccc(OCc2nc3ccccc3s2)cc1,,ClCCl,,CCN(CC)CC,O,val
US05891603,Cc1ccc2c(c1)C(=O)OC2=O.NO>>Cc1ccc2c(c1)C(=O)N(O)C2=O,,O,,Cl,[Na+].[OH-],val
US20050113430A1,CC(=O)OC(C)=O.CC(C)(S)[C@@H](N)C(=O)O.O=Cc1ccccc1>>CC(=O)N1[C@H](c2ccccc2)SC(C)(C)[C@@H]1C(=O)O,,CCO,O,,,val
US20060247320A1,CC(C)(C)C1C=CC(=O)CC1.[Li]C>>CC1=CC(=O)CCC1C(C)(C)C,,CCOCC,,,,val
US20160052884A1,CCOC(=O)C(CC)OS(=O)(=O)C(F)(F)F.COc1c[nH]c(=O)cc1-c1cc(Cl)ccc1OC(F)F>>CCOC(=O)C(CC)n1cc(OC)c(-c2cc(Cl)ccc2OC(F)F)cc1=O,,C1CCOC1,,[H-].[Na+],,val
US04619938,CCC=CCC=CCC=CCCCCCCCC(=O)O.O=C(Cl)C(=O)Cl>>CCC=CCC=CCC=CCCCCCCCC(=O)Cl,,ClC(Cl)Cl,,,,val
US20060063814A1,COC(=O)c1csc(NC(=O)[C@H](Cc2ccc(C(N)=O)cc2)N2C(=O)NC(O)(c3ccc4c(c3)OCO4)C2=O)n1>>COC(=O)c1csc(NC(=O)[C@H](Cc2ccc(C(N)=O)cc2)N2C(=O)NC(c3ccc4c(c3)OCO4)C2=O)n1,[Zn],CC(=O)O,,O=C([O-])O.[Na+],,val
US04034043,Cc1ccccc1NC=O.ClCl>>Cc1cc(Cl)ccc1N.Cl,,ClC(Cl)Cl,,CO,,val
US04174958,CC(C)(C)C(=O)Cl.NNc1ccc([N+](=O)[O-])cc1Cl>>CC(C)(C)C(=O)NNc1ccc([N+](=O)[O-])cc1Cl,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20150210635A1,COC(=O)C12CC3CC(C1)C(N)C(C3)C2.O=C(O)c1cccc([N+](=O)[O-])c1>>COC(=O)C12CC3CC(C1)C(NC(=O)c1cccc([N+](=O)[O-])c1)C(C3)C2,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US20160244446A1,C[C@@H](Oc1cc(B2OC(C)(C)C(C)(C)O2)cc2nn(C)cc12)[C@H]1CNC(=O)C1.FC(F)(F)CCn1cc(Br)cn1>>C[C@@H](Oc1cc(-c2cnn(CCC(F)(F)F)c2)cc2nn(C)cc12)[C@H]1CNC(=O)C1,,CCO,O,O=C([O-])[O-].[Na+].[Na+],,val
US20050277628A1,NC1(C(=O)O)CCOC1.O=C(O)c1ccc(Br)s1>>O=C(NC1(C(=O)O)CCOC1)c1ccc(Br)s1,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US05646173,CC(O)CN.O=CCC1CC(=O)c2ccccc2O1>>CC(O)Cn1ccc2c1-c1ccccc1OC2,Cc1ccc(S(=O)(=O)O)cc1,,,Cc1ccccc1,O,val
US04284558,C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@]12F>>C[C@]12CC[C@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@]12F,[Pd],CCO,,[H][H],,val
US20060276508A1,CCOC(=O)C(C)(C)Oc1cccc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)c1>>CCOC(=O)C(C)(C)Oc1cccc(C(=O)NC2CCNCC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120220577A1,CCOC(=O)COc1cccc(NC(=O)COc2cc(C(=O)OC)cc3cc(Cl)cc(Cl)c23)c1>>O=C(O)COc1cccc(NC(=O)COc2cc(C(=O)O)cc3cc(Cl)cc(Cl)c23)c1,,C1CCOC1,O,[Na+].[OH-],,val
US20160083400A1,NC(CCO)c1ccc(Cl)cc1.O=c1nc(Cl)[nH]n2c(C3CCN(Cc4ccccc4)CC3)ncc12>>O=c1nc(NC(CCO)c2ccc(Cl)cc2)[nH]n2c(C3CCN(Cc4ccccc4)CC3)ncc12,,CCCCO,,CCN(C(C)C)C(C)C,[I-].[Na+],val
US20080292585A1,CN(C)CCN1C(=O)c2cccc3cc4cccc(N)c4c(c23)C1=O.FC(F)(F)c1ccc(N=C=S)cc1>>CN(C)CCN1C(=O)c2cccc3cc4cccc(NC(=S)Nc5ccc(C(F)(F)F)cc5)c4c(c23)C1=O,,CC#N,,,,val
US20050026964A1,NC(=O)c1cn(CCOC2CCCCO2)c(=O)cc1Nc1ccc(I)cc1F>>NC(=O)c1cn(CCO)c(=O)cc1Nc1ccc(I)cc1F,,CCO,O,Cl,,val
US20120071489A1,COC(=O)C1(C(=O)N2CCN(c3ccccc3C(C)(C)C)CC2)CC1>>CC(C)(C)c1ccccc1N1CCN(C(=O)C2(C(=O)O)CC2)CC1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20120035214A1,COC(=O)Cl.COC[C@H](C)COCc1ccc([C@@]2(O)CCN(C(=O)OC(C)(C)C)C[C@@H]2c2ccc(-c3ccccc3CCN)cc2C)cc1>>COC[C@H](C)COCc1ccc([C@@]2(O)CCN(C(=O)OC(C)(C)C)C[C@@H]2c2ccc(-c3ccccc3CCNC(=O)OC)cc2C)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20080139631A1,FC(F)(F)c1cccc(-c2nc(CCl)no2)c1.N#Cc1ccc2[nH]c(CC(F)(F)F)cc2c1C(F)(F)F>>N#Cc1ccc2c(cc(CC(F)(F)F)n2Cc2noc(-c3cccc(C(F)(F)F)c3)n2)c1C(F)(F)F,,CCOC(C)=O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20090215776A1,CC(C)(C)OC(=O)N1CCN(Cc2ccc(-c3cncc(-c4cc(N)nc(-c5ccccn5)c4)c3)cc2)CC1>>Nc1cc(-c2cncc(-c3ccc(CN4CCNCC4)cc3)c2)cc(-c2ccccn2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100256192A1,BrCC1CC1.CC(C)(C)OC(=O)N1CC2C(C#N)C2C1>>CC(C)(C)OC(=O)N1CC2C(C1)C2(C#N)CC1CC1,,Cc1ccccc1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20100125061A1,COC(=O)CC(C)C(=O)OC.O=Cc1ccc(F)cc1>>COC(=O)C(=Cc1ccc(F)cc1)C(C)C(=O)O,,Cc1ccccc1,,CO,[H-].[Na+],val
US20040180940A1,Cc1c([N+](=O)[O-])cc(Br)c(Oc2ccc(O)c(C(C)C)c2)c1Br.O=C(O)C(F)(F)F>>Cc1c([N+](=O)[O-])cc(Br)c(Oc2cc(C=O)c(O)c(C(C)C)c2)c1Br,,Cl,,,,val
US20110060142A1,CC(C)(C)[Si](C)(C)C(OC(c1cc(Cl)cc(Cl)c1)[Si](C)(C)C(C)(C)C)c1cc(Cl)cc(Cl)c1.O=C(Cl)c1ccc(Cl)cc1>>O=C(c1ccc(Cl)cc1)c1c(Cl)cc(CO)cc1Cl,,C1CCOC1,CCCCCC,Cl,[Li]CCCC,val
US20060252715A1,CCC(=O)O[C@@H]1[C@@H](COC(C)=O)O[C@@H](n2ccc3c(Cl)ncnc32)[C@@H]1OC(C)=O.O=[N+]([O-])O>>CCC(=O)O[C@@H]1[C@@H](COC(C)=O)O[C@@H](n2cc([N+](=O)[O-])c3c(Cl)ncnc32)[C@@H]1OC(C)=O,,ClCCl,,O=S(=O)(O)O,,val
US20070208005A1,CCNC(=O)c1cnc(Cc2ccc3c(c2)CCNCC3)cn1.O=C1CCC1>>CCNC(=O)c1cnc(Cc2ccc3c(c2)CCN(C2CCC2)CC3)cn1,CC(=O)O,CO,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100004331A1,CCOC(=O)Cc1ccc(OC)c(O)c1.O=Cc1cc(Br)ccc1F>>CCOC(=O)Cc1ccc(OC)c(Oc2ccc(Br)cc2C=O)c1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20120316161A1,Cc1ccc([Mg]Br)cc1.Cc1nc(C#N)c(N)n1C.[OH-]>>Cc1ccc(C(=O)c2nc(C)n(C)c2N)cc1,,C1CCOC1,,Cl,,val
US05145958,COC(=O)c1cc(Cl)c(N)c(Cl)c1>>Nc1c(Cl)cccc1Cl,,O,,,,val
US20150238516A1,CCC(CC)(CO)CO.O=Cc1ccc(C(=O)O)cc1>>CCC1(CC)COC(c2ccc(C(=O)O)cc2)OC1,,ClCCl,,CCOCC,FB(F)F,val
US20130252943A1,C[C@@H](NCCc1nc(COc2ccccc2)oc1C(=O)O)C(C)(C)C>>C[C@@H](N1CCc2nc(COc3ccccc3)oc2C1=O)C(C)(C)C,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20100197756A1,Cc1ccc2c(c1)c(S(=O)(=O)c1ccc(Cl)cc1)c(C)n2CC(=O)O.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)Cn1c(C)c(S(=O)(=O)c2ccc(Cl)cc2)c2cc(C)ccc21,,ClCCl,,,,val
US20120108583A1,COC(=O)c1cc(N)c(N)cc1O.Fc1cccc(Cl)c1N=C=S>>COC(=O)c1cc2nc(Nc3c(F)cccc3Cl)[nH]c2cc1O,,CC#N,,,,val
US20080293767A1,Cc1c(Cl)cc(C(=O)NCC2CCN(C(=O)OC(C)(C)C)CC2)c(=O)n1C(C)C>>Cc1c(Cl)cc(C(=O)NCC2CCNCC2)c(=O)n1C(C)C,,CO,Cl,O=C([O-])[O-].[K+].[K+],,val
US20090028787A1,CN.COc1ccc2sc(-c3ccc(F)nc3)nc2c1>>CNc1ccc(-c2nc3cc(OC)ccc3s2)cn1,,CCO,,ClCCl,O,val
US20090048258A1,CC(C)(C)OC(=O)Nc1cc(-c2ccccc2)cc(-c2ccccc2)c1>>Nc1cc(-c2ccccc2)cc(-c2ccccc2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160221972A1,COC(=O)c1ccc2c(c1)OC[C@H](C(C)C)N(C(=O)Nc1ccc(OC)cc1)C2.NO>>COc1ccc(NC(=O)N2Cc3ccc(C(=O)NO)cc3OC[C@@H]2C(C)C)cc1,,C1CCOC1,,CO,[Na+].[OH-],val
US05840732,CCOC=C1SC(=O)NC1=O.CCS>>CCSC=C1SC(=O)NC1=O,,CCO,,O,[Na],val
US05536725,Clc1ccccc1CBr.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Clc1ccccc1C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-],,Cc1ccccc1,,,,val
US20100160255A1,CC1(C)CC2(CCCN(C3CCN(C(=O)c4nc(-c5ccccc5)sc4N)CC3)C2)C(=O)O1.CCN=C=O>>CCNC(=O)Nc1sc(-c2ccccc2)nc1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1,,CCCCCC,,CC(C)OC(C)C,,val
US05252538,CCOC(=O)c1cc(C(=O)OCC)c(=O)[nH]c1C(=O)OCC.O=P(Cl)(Cl)Cl>>CCOC(=O)c1cc(C(=O)OCC)c(C(=O)OCC)nc1Cl,,CN(C)C=O,,,,val
US20140249134A1,CCOC(=O)[C@@H]1C[C@H]1c1cc(-n2nc(C)nc2C)nc(C(F)(F)F)n1>>Cc1nc(C)n(-c2cc([C@@H]3C[C@H]3CO)nc(C(F)(F)F)n2)n1,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20110318388A1,CCOc1ccc(-c2nc(-c3ccc4oc(C(C)O)cc4c3)no2)cc1OCC>>CCOc1ccc(-c2nc(-c3ccc4oc(C=O)cc4c3)no2)cc1OCC,O=[Mn]=O,C1COCCO1,,,,val
US20130324528A1,Brc1ccnc2cn[nH]c12.CI>>Cn1cc2nccc(Br)c2n1,,C1CCOC1,,[H-].[Na+],,val
US04954518,CC(=O)OC(C)=O.CCOC(=O)CC(=O)c1cc(Oc2ccccc2)c(NS(C)(=O)=O)cc1O>>CCOC(=O)c1c(C)oc2cc(N(C(C)=O)S(C)(=O)=O)c(Oc3ccccc3)cc2c1=O,,CCOC(C)=O,O,Cl,CC(=O)[O-].[Na+],val
US20090105275A1,CCOC(=O)C(CC(C)C)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCCN(C(c3ccccc3)c3ccccc3)C2)c1>>CC(C)CC(C(=O)O)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCCN(C(c3ccccc3)c3ccccc3)C2)c1,,CCO,,[K+].[OH-],,val
US20010051651A1,CCOC(=O)Cc1cc(CC)c(C(=O)c2ccc(Cl)cc2)n1C>>CCc1cc(CC(=O)O)n(C)c1C(=O)c1ccc(Cl)cc1,,CCO,,[Na+].[OH-],,val
US20020042409A1,CC(C)(C)OC(=O)NC1C2CN(C(=O)c3cc4nccc(Cl)c4s3)CC21>>NC1C2CN(C(=O)c3cc4nccc(Cl)c4s3)CC12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060058366A1,C#CCO[Si](C)(C)C(C)(C)C.O=C(Nc1ccccc1/C=C/c1n[nH]c2ccc(I)cc12)c1ccccc1>>CC(C)(C)[Si](C)(C)OCC#Cc1ccc2[nH]nc(/C=C/c3ccccc3NC(=O)c3ccccc3)c2c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,CCN(CC)CC,,val
US05929291,CC(=O)C(C)=CCC1CC2CC2(C)C1(C)C>>CC(=O)C(C)C=CC1CC2CC2(C)C1(C)C,,C1CCOC1,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20100240702A1,C=CS(=O)(=O)Oc1ccccc1.Cc1cccc2scc(Cn3c(=O)[nH]c4ccccc43)c12>>Cc1cccc2scc(Cn3c(=O)n(CCS(=O)(=O)Oc4ccccc4)c4ccccc43)c12,,C1CCOC1,O,[Na+].[OH-],[Cl-].[NH4+],val
US20070299130A1,COc1cc2c(cc1[N+](=O)[O-])OC(C)(C)[C@@H]1O[C@H]21.[NH4+]>>COc1cc2c(cc1[N+](=O)[O-])OC(C)(C)[C@H](O)[C@H]2N,,CCO,,O,,val
US20090306066A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)N(C(=O)OC(C)(C)C)c1nc(Cl)nc(Cl)c1F.C[C@H]1COCCN1>>C[C@H]1COCCN1c1nc(Cl)nc(N(C(=O)OC(C)(C)C)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1F,,CCOCC,CN(C)C=O,CCN(C(C)C)C(C)C,Cl,val
US04045560,Cl.c1ccc(CN2CCOC(CC34CCC(c5ccccc53)c3ccccc34)C2)cc1>>Cl.c1ccc2c(c1)C1CCC2(CC2CNCCO2)c2ccccc21,[Pd],CC(=O)O,,,,val
US05910506,CC(C)c1c(Sc2cccc(Cl)c2)nc(COCc2ccccc2)n1C>>CC(C)c1c(Sc2cccc(Cl)c2)nc(CO)n1C,,Cl,,O=C([O-])O.[Na+],,val
US20140171475A1,NCc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1Cl.O=C(Cl)CCC(F)(F)F>>O=C(CCC(F)(F)F)NC(C1=NOC(c2cc(Cl)cc(Cl)c2)(C(F)(F)F)C1)c1ccccc1Cl,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20140343053A1,CCCC[Sn](CCCC)(CCCC)c1cccnc1.O=c1n(CCc2ccc3ccccc3n2)nc2ccc(Br)cn12>>O=c1n(CCc2ccc3ccccc3n2)nc2ccc(-c3cccnc3)cn12,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,CN(C)C=O,,,,val
US20070129334A1,COc1ccc(I)c(Sc2nc3c(N)ncnc3n2CCCOC(C)=O)c1>>COc1ccc(I)c(Sc2nc3c(N)ncnc3n2CCCO)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20140094507A1,CC(C)(C)OC(=O)[C@H](N)Cc1ccccc1.O=S(=O)(Cl)c1ccccc1F>>O=C(O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccccc1F,,ClCCl,,CCN(CC)CC,,val
US20130315992A1,CC(=O)N1c2ccc(N(C)C)cc2Sc2cc(N(C)C)ccc21.O=S(=O)(O)CCS(=O)(=O)O>>C[NH+](C)c1ccc2c(c1)Sc1cc([NH+](C)C)ccc1N2.O=S(=O)([O-])CCS(=O)(=O)[O-],,CCO,,,,val
US20040167171A1,CN(C)c1ccc(Br)cc1.COc1ccc(N2CCN(c3c(C)c(C)c4c(c3C)C(=O)C(C)(C)O4)CC2)cc1>>COc1ccc(N2CCN(c3c(C)c(C)c4c(c3C)C(O)(c3ccc(N(C)C)cc3)C(C)(C)O4)CC2)cc1,,CCCCCC,CCOC(C)=O,,,val
US20020072514A1,CCS(=O)(=O)Cl.NC1CCCCc2ccc(F)cc21>>CCS(=O)(=O)NC1CCCCc2ccc(F)cc21,,C1CCOC1,,CCN(CC)CC,,val
US06107482,C=CCOc1nc(OCC=C)nc(OCC=C)n1.[N-]=[N+]=NCCCO>>C=CCOc1nc(OCC=C)nc(OCCCN=[N+]=[N-])n1,,C1CCOC1,,[H-].[Na+],,val
US20110275678A1,NC(CO)c1ccccc1.O=C(OCc1ccncc1)Oc1ccc([N+](=O)[O-])cc1>>O=C(N[C@@H](CO)c1ccccc1)OCc1ccncc1,CN(C)c1ccncc1,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20100160315A1,COC(=O)c1ccccc1N=C=S.NN>>Nn1c(=S)[nH]c2ccccc2c1=O,,C1CCOC1,,O,,val
US20140135360A1,BrBr.CC(C)(C)N1COc2c(cccc2-c2ccccc2)C1>>CC(C)(C)N1COc2c(cc(Br)cc2-c2ccccc2)C1,,CC#N,CCO,Cl,O,val
US20050059651A1,CI.O=C(CCc1ccc([N+](=O)[O-])cc1O)N1CCCC1>>COc1cc([N+](=O)[O-])ccc1CCC(=O)N1CCCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130261100A1,COC(=O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3N3CC(Nc4ccc(F)cc4C)C3)CC2)cc1>>Cc1cc(F)ccc1NC1CN(c2ncc(Cl)cc2C(=O)NC2(c3ccc(C(=O)O)cc3)CC2)C1,,C1COCCO1,O,[Na+].[OH-],,val
US20130336920A1,CN(CC=O)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)N[C@H]3CCCc4ccccc43)ccn2)c1.CNCCOCCOCCOCCOCCOCCOCCOC>>COCCOCCOCCOCCOCCOCCOCCN(C)CCN(C)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)N[C@H]3CCCc4ccccc43)ccn2)c1,,CCO,CCOC(C)=O,CC(=O)O,[BH3-]C#N.[Na+],val
US20070155805A1,CCCCC(CCOc1ccc(OCC(=O)OCC)c(CC)c1)c1sc2cc(C(F)(F)F)ccc2c1C>>CCCCC(CCOc1ccc(OCC(=O)O)c(CC)c1)c1sc2cc(C(F)(F)F)ccc2c1C,,C1CCOC1,CO,[Na+].[OH-],,val
US04778513,NS(=O)(=O)c1cccnc1Cl.OC1CCCC1>>NS(=O)(=O)c1cccnc1OC1CCCC1,,CCOC(C)=O,CN(C)C=O,Cl,[H-].[Na+],val
US20060264460A1,N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(Cl)c1.O=Cc1cccc(Br)n1>>N#Cc1cnc2ccc(NCc3cccc(Br)n3)cc2c1Nc1ccc(F)c(Cl)c1,,CCO,,[BH3-]C#N.[Na+],,val
US05013847,CCC(C)Oc1ccc(O)cc1.Cc1cc(CCl)on1>>CCC(C)Oc1ccc(OCc2cc(C)no2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020061996A1,CCOc1ccc(/C=C/C(=O)OC)cc1OCC>>CCOc1ccc(/C=C/C(=O)O)cc1OCC,,CO,,O,[K+].[OH-],val
US20130059849A1,CCOC(=O)c1cc(C2CC2)nc2c1c(C)nn2C(C)(C)C>>Cc1nn(C(C)(C)C)c2nc(C3CC3)cc(C(=O)O)c12,,CCO,,[Na+].[OH-],,val
US20120040999A1,NNC(=O)c1ccn[nH]1.O=C(Cl)CCl>>O=C(CCl)NNC(=O)c1ccn[nH]1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20050130989A1,Clc1cccc(N2CCNCC2)c1.O=C(O)c1cccn1-c1ccccc1>>O=C(c1cccn1-c1ccccc1)N1CCN(c2cccc(Cl)c2)CC1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20050020574A1,BrCc1ccccc1.CSc1nc2cnn(Cc3cccc4ccccc34)c(=O)c2[nH]1>>CSc1nc2cnn(Cc3cccc4ccccc34)c(=O)c2n1Cc1ccccc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20020183320A1,Nc1nccs1.O=Cc1ccccn1.[C-]#[N+]c1c(C)cccc1C>>Cc1cccc(C)c1Nc1c(-c2ccccn2)nc2sccn12,,[O-][Cl+3]([O-])([O-])O,,,,val
US20060281763A1,CC(C)N=C=O.COc1cnc(-c2cc(Cl)ccc2F)nc1Nc1ccncc1C(=O)NCCCN>>COc1cnc(-c2cc(Cl)ccc2F)nc1Nc1ccncc1C(=O)NCCCNC(=O)NC(C)C,,CCOC(C)=O,,CCN(CC)CC,,val
US20130317100A1,ClCCCBr.Oc1ccc(Br)cc1>>ClCCCOc1ccc(Br)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20070004725A1,CN(C)C(=O)C(Cc1ccc(Oc2ccc(CCC(=O)NOCc3ccccc3)cc2)cc1)NC(=O)OC(C)(C)C>>CN(C)C(=O)C(Cc1ccc(Oc2ccc(CCC(=O)NO)cc2)cc1)NC(=O)OC(C)(C)C,[Pd],CO,,[H][H],,val
US04565877,C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)O.O=S(Cl)Cl>>C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)Cl,,CCCCCC,,c1ccccc1,,val
US20090156575A1,C#CC(C)(C)Cl.O=Cc1ccccc1O>>C#CC(C)(C)Oc1ccccc1C=O,Cl[Cu],CC#N,,C1CCC2=NCCCN2CC1,,val
US20090042955A1,CCCCCCCCc1ccc2c(c1)CCC(C(NC(C)=O)(C(=O)OCC)C(=O)OCC)C2O>>CCCCCCCCc1ccc2c(c1)CCC(C(NC(C)=O)(C(=O)OCC)C(=O)OCC)=C2,,CC(=O)OC(C)=O,,CCOCC,,val
US20160137653A1,N[C@@H]1CC[C@@H](c2ccnc3ccc(F)cc23)CC1.O=C(Cl)Cc1ccc(Cl)cc1>>O=C(Cc1ccc(Cl)cc1)N[C@@H]1CC[C@@H](c2ccnc3ccc(F)cc23)CC1,,C1CCOC1,,CCN(CC)CC,,val
US06002008,CC#CC(=O)O.N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(Cl)c1>>CC#CC(=O)Nc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1,,C1CCOC1,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20150284358A1,Clc1ccc(Cl)c(Cn2ccnc2-c2cccnc2)c1.O=C1CCC(=O)N1Br>>Clc1ccc(Cl)c(Cn2c(Br)cnc2-c2cccnc2)c1,,ClCCl,,O,,val
US05364866,COc1ccccc1OCCCCl.Fc1ccc2c(C3CCNCC3)noc2c1.O=C(O)/C=C/C(=O)O>>COc1ccccc1OCCCN1CCC(c2noc3cc(F)ccc23)CC1.O=C(O)/C=C/C(=O)O,,CC#N,CCO,O=C([O-])[O-].[K+].[K+],,val
US05486514,CC(C)(C)CCCS(=O)(=O)[O-].O=C1CC(=O)N(c2ccccc2)c2ccccc2N1>>CC(C)(C)CCN1C(=O)CC(=O)N(c2ccccc2)c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20140204457A1,COS(=O)(=O)c1c(C)cc(C)cc1C.Cc1ccc2ccccc2n1>>Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1.Cc1ccc2ccccc2[n+]1C,,COCCOC,,,,val
US20060004046A1,CCOc1c(C#N)cnc2ccc(C=O)cc12.COc1ccc(/C=C2\SC(=N)NC2=O)cc1OC1CCCC1>>CCOc1c(C#N)cnc2ccc(/C=C3\SC(N)=NC3=O)cc12,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20070149542A1,COCCBr.CS(=O)(=O)Oc1cccc(C2CCNCC2)c1F>>COCCN1CCC(c2cccc(OS(C)(=O)=O)c2F)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050176733A1,CCOC(=O)c1ccc(OCCCN)c([N+](=O)[O-])c1.O=C(Cl)c1ccc(Cl)cc1>>CCOC(=O)c1ccc(OCCCNC(=O)c2ccc(Cl)cc2)c([N+](=O)[O-])c1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20040198736A1,CCOC(=O)Cc1ccc([N+](=O)[O-])c(Oc2cc(Br)cc(C#N)c2)c1F>>CCOC(=O)Cc1ccc(N)c(Oc2cc(Br)cc(C#N)c2)c1F,[Fe],CCO,O,[Cl-].[NH4+],,val
US06114390,NC(=N[N+](=O)[O-])NCCC[C@@H](NC(=O)OCc1ccc2ccccc2c1)C(=O)O.NCc1ccc(CNC(N)=O)cc1>>NC(=O)NCc1ccc(CNC(=O)[C@@H](CCCNC(N)=N[N+](=O)[O-])NC(=O)OCc2ccc3ccccc3c2)cc1,,CO,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20150225367A1,COCCS(=O)(=O)NC1CCN(c2ccc(-c3c[nH]c4cc(F)ccc34)cn2)CC1>>O=S(=O)(CCO)NC1CCN(c2ccc(-c3c[nH]c4cc(F)ccc34)cn2)CC1,,ClCCl,,BrB(Br)Br,,val
US20080171772A1,CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(O)cc2n1Cc1ccccc1.CCC(C)I>>CC(C)COc1ccc2c(C(=O)NCc3ccc(F)c(F)c3)c(C(C)C)n(Cc3ccccc3)c2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120101100A1,NNC(=O)c1cncc(Br)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>FC(F)(F)c1nnc(-c2cncc(Br)c2)o1,,Cc1ccccc1,,,,val
US20110003787A1,COC[C@H](C)Oc1cc(O)cc(-c2ccc(-c3nccs3)n2C(=O)OC(C)(C)C)c1.CS(=O)(=O)c1ccc(F)cn1>>COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc(-c2ccc(-c3nccs3)[nH]2)c1,,CN(C)C=O,,O,,val
US20100041748A1,CC(C)CC(NC(=O)OCc1ccccc1)C(=O)O.COC(=O)c1cc(N)ccc1O>>COC(=O)c1cc(NC(=O)C(CC(C)C)NC(=O)OCc2ccccc2)ccc1O,,CC#N,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120035163A1,CCOC(=O)CC1CN=C(c2cc3cc(Oc4ccc(S(C)(=O)=O)nc4)cc(CC)c3[nH]2)S1>>CCc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C3=NCC(CC(=O)O)S3)[nH]c12,,C1CCOC1,,CO,[K+].[OH-],val
US20060281700A1,CON=Cc1c(N)ncnc1N1CCC(N)CC1.O=C(Nc1ccc(OC2CCC2)nc1)Oc1ccc([N+](=O)[O-])cc1>>CON=Cc1c(N)ncnc1N1CCC(NC(=O)Nc2ccc(OC3CCC3)nc2)CC1,,CC#N,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20030199440A1,CC(C)(C)OC(=O)C[C@@H](N)C(=O)OC(C)(C)C.O=S(=O)(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>CC(C)(C)OC(=O)C[C@@H](NS(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1)C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20130190330A1,FC(F)(F)c1ccccc1CBr.O=c1n(S(=O)(=O)c2ncn[nH]2)nc(-c2ccc(Cl)cc2)n1C1CC1>>O=c1n(S(=O)(=O)c2ncnn2Cc2ccccc2C(F)(F)F)nc(-c2ccc(Cl)cc2)n1C1CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070179298A1,CCCCC(CO)C(=O)O.C[C@@H](N)c1ccccc1>>CCCC[C@H](CO)C(=O)[O-].C[C@@H]([NH3+])c1ccccc1,,CCOC(C)=O,,CC(C)O,,val
USRE028728,CC(O)CO.CCCCCCCC/C=C\CCCCCCCC(=O)O>>CC(O)CO.CCCCCCCC/C=C\CCCCCCCC(=O)O,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1C,,O,,val
US20120046267A1,Nc1nccc2cc(Cl)oc12.OB(O)c1cccc2cnccc12>>Nc1nccc2cc(-c3cccc4cnccc34)oc12,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20030220307A1,CCC(O)(C#CCC[C@H](C)C1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C)CC>>CCC(O)(C#CCC[C@H](C)C1=CC[C@H]2C3=CC=C4C[C@@H](O)C[C@H](O)[C@]4(C)[C@H]3CC[C@]12C)CC,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160024097A1,CCOC(=O)C(C#N)=C(O)C1CC1.CCOS(=O)(=O)C(F)(F)F>>CCOC(=O)C(C#N)=C(OCC)C1CC1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06294532B1,CI.S=c1[nH]cnc2cc(OCc3ccccc3)ccc12>>CSc1ncnc2cc(OCc3ccccc3)ccc12,,C1CCOC1,,Cl,[Na+].[OH-],val
US04751240,CCCCCCSCCCCCCCCCCC1c2ccc(OC)cc2CCC1c1ccc(F)cc1>>CCCCCCSCCCCCCCCCCC1c2ccc(O)cc2CCC1c1ccc(F)cc1,,ClCCl,,BrB(Br)Br,,val
US05231102,COC(=O)c1cc(C(=O)O)nc2cc(Cl)cc(Cl)c12>>COC(=O)[C@@H]1C[C@H](C(=O)O)Nc2cc(Cl)cc(Cl)c21,O=[Pt],CO,,[H][H],,val
US06174881B1,N.O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1)=NCC(=S)N2>>NC1=Nc2ccc([N+](=O)[O-])cc2C(c2ccccc2)=NC1,,C1CCOC1,,,,val
US20150037840A1,CC(C)(C)OC(=O)CI.C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O>>C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)OCC(=O)O,,C1CCOC1,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20160128326A1,C#CCBr.COC1=C(c2c(F)cc(-c3ccc(F)cc3)cc2OC)C(=O)CC1>>C#CCC1CC(OC)=C(c2c(F)cc(-c3ccc(F)cc3)cc2OC)C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20140039030A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCNCCN>>CCNCCNC(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20080312208A1,CCOC(=O)c1cc(C#N)c(Cl)nc1C(C)C.O=C(O)C1CNC1>>CCOC(=O)c1cc(C#N)c(N2CC(C(=O)O)C2)nc1C(C)C,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20070249591A1,CCOC(=O)C(=O)CBr.NC(=S)c1ccc([N+](=O)[O-])cc1>>CCOC(=O)c1csc(-c2ccc([N+](=O)[O-])cc2)n1,,CCO,,CCN(CC)CC,,val
US20040127574A1,Cl.O=CNC(Cc1ccc(C(F)(F)F)cc1)C(=O)c1ccc(F)cc1>>Cl.NC(Cc1ccc(C(F)(F)F)cc1)C(=O)c1ccc(F)cc1,,CO,,,,val
US20080090818A1,CN(C)C=Nc1nc(Br)cnc1Br.NO>>ON=CNc1nc(Br)cnc1Br,,CO,,Cl,,val
US20030158177A1,CC(=O)N1CCc2cc(C(O)CCN(C)C)ccc21>>CN(C)C/C=C/c1ccc2c(c1)CCN2,,Cl,,,,val
US04512991,C=CC[Mg]Cl.Nc1nc(Cl)c(Cl)nc1C=O>>C=CCC(O)c1nc(Cl)c(Cl)nc1N,,C1CCOC1,CCOCC,[Cl-].[NH4+],,val
US20100168110A1,COc1ccc(OC)c2c1CCC2=O>>COc1ccc(OC)c2c1CCC2,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20120149718A1,CC(=O)OCc1cnc(NC(=O)OC(C)(C)C)cn1.O=C(O)C(F)(F)F>>CC(=O)OCc1cnc(N)cn1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20120010190A1,Cn1cc(C(=O)CC(c2ccc(C(=O)O)c(F)c2)c2ccccc2Cl)ccc1=O.NC1COC1>>Cn1cc(C(=O)CC(c2ccc(C(=O)NC3COC3)c(F)c2)c2ccccc2Cl)ccc1=O,,C1CCOC1,,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,,val
US20130210804A1,COC(=O)[C@@H]1CC[C@H]2CCc3nc(O)ccc3C(=O)N2C1.O=P(Cl)(Cl)Cl>>COC(=O)[C@@H]1CC[C@H]2CCc3nc(Cl)ccc3C(=O)N2C1,,CC#N,,O=C([O-])O.[Na+],,val
US04028386,COC(=O)[O-].COC(C)(C)CCCC(C)=CCCC(C)=O>>COC(=O)CC(=O)CCC=C(C)CCCC(C)(C)OC,,CN(C)C=O,,Cl,[H-].[Na+],val
US20120059014A1,CC(CO)COCc1ccccc1>>CC(C=O)COCc1ccccc1,,CCOC(C)=O,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20100144760A1,COC(=O)c1nc(C)ccc1-n1ccc(C)n1>>Cc1ccc(-n2ccc(C)n2)c(C(=O)O)n1,,C1CCOC1,O,[Li+].[OH-],,val
US20050107419A1,C(=NC1CCCCC1)=NC1CCCCC1.CC1(C)OC(=O)CC(=O)O1.ClCCl.O=C(O)CCCC(F)(F)F>>CCOC(=O)CC(=O)CCC(F)(F)F,CN(C)c1ccncc1,ClCCl,,,,val
US06660759B1,CC(=O)O[C@H]1C[C@H](c2nc(-c3ccccc3)c(-c3ccccc3)o2)N(C(=O)OCc2ccccc2)C1>>O=C(OCc1ccccc1)N1C[C@@H](O)C[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1,,CC#N,CO,Cl,C[O-].[Na+],val
US05728899,C=COC(C)=O.CCN(CC)CC.COC(C)(C)C.ClC(Cl)Cl.O[C@@H]1C=C[C@H](OCc2ccccc2)C1>>CC(=O)O[C@@H]1C=C[C@H](OCc2ccccc2)C1.O[C@@H]1C=C[C@H](OCc2ccccc2)C1,,COC(C)(C)C,,,,val
US20070155725A1,COC(=O)C1CN(Cc2ccccc2)CCN1Cc1ccccc1>>OCC1CN(Cc2ccccc2)CCN1Cc1ccccc1,,O,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05238602,C=CCCCC(CO)CO.C=CCCOc1ccc(C=O)cc1>>C=CCCC[C@@H]1CO[C@@H](c2ccc(OCCC=C)cc2)OC1,O=S(=O)(O)O,Cc1ccccc1,,,,val
US20100029728A1,CC(N)c1ccccc1.CCOc1cc(C2=NOC(C)(C(=O)O)C2)ccc1OC(F)F>>CCOc1cc(C2=NOC(C)(C(=O)N[C@H](C)c3ccccc3)C2)ccc1OC(F)F,,ClCCl,c1ccccc1,O=C(Cl)C(=O)Cl,,val
US20040097498A1,CCCOc1ccc(N)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1.O=C=NS(=O)(=O)c1ccc(F)cc1>>CCCOc1ccc(NC(=O)NS(=O)(=O)c2ccc(F)cc2)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1,,C1CCOC1,,,,val
US20100240717A1,C=C(C)CBr.CC(=O)CC(C)=O>>C=C(C)CC(C(C)=O)C(C)=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20070032529A1,O=C(Cl)C(=O)Cl.O=C(O)c1cc([N+](=O)[O-])[nH]n1>>O=C(Cl)c1cc([N+](=O)[O-])[nH]n1,CN(C)C=O,ClC(Cl)Cl,,,,val
US20030120079A1,COC(=O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2C)c1>>Cc1ccccc1-c1cccc(C(O)/C=C/[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1,,CO,,,,val
US04435403,COC(=O)c1cccc2[nH]ccc12.Cc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)c1cccc2c1ccn2S(=O)(=O)c1ccc(C)cc1,,CCN(CC)CC,ClCCl,,,val
US20030125339A1,CC(C)(C)c1ccc(N)cc1.O=C(Cl)c1cccnc1F>>CC(C)(C)c1ccc(NC(=O)c2cccnc2F)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20150344919A1,CC(C)CC(C#N)CC(=O)O>>CC(C)C[C@H](CN)CC(=O)O,[Ni],O,,[Na+].[OH-],,val
US06084106,CCO[Si](CCCN)(OCC)OCC.O=C1OC(=O)c2cc(C#Cc3ccccc3)ccc21>>CCO[Si](CCCN1C(=O)c2ccc(C#Cc3ccccc3)cc2C1=O)(OCC)OCC,,C1CCOC1,,,,val
US07214746B2,BrC1=Cc2ccccc2C1.CC(C)(C)P>>CC(C)(C)PC1=Cc2ccccc2C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCN(CC)CC,,val
US04780504,Nc1cccc(CC(=O)O)c1.O=Cc1cc(Cl)ccc1O>>O=C(O)Cc1cccc(N=Cc2cc(Cl)ccc2O)c1,,CO,,CCO,,val
US20050032786A1,CC(C)(Cc1ccnc(C#N)c1)C(=O)OCC[Si](C)(C)C.COC(=O)c1ccccc1S>>CC(C)(Cc1ccnc(-c2nc(=O)c3ccccc3s2)c1)C(=O)OCC[Si](C)(C)C,,Cc1ccccc1,,CCN(CC)CC,,val
US20130338140A1,CC(C)Nc1ncc2c(n1)CN(C(=O)OC(C)(C)C)CC2=O>>CC(C)Nc1ncc2c(n1)CN(C(=O)OC(C)(C)C)CC2O,,CO,,[BH4-].[Na+],,val
US20150011528A1,CC(C)(C)OC(=O)Nc1nc2ccccc2s1.CCOC(=O)C(Br)CC>>CCOC(=O)C(CC)n1c(=NC(=O)OC(C)(C)C)sc2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120088767A1,COC(=O)c1cc(N2CCOCC2)cc2c1nc(C)n2Cc1cccc2cccnc12>>Cc1nc2c(C(=O)O)cc(N3CCOCC3)cc2n1Cc1cccc2cccnc12,,C1CCOC1,,[Li+].[OH-],,val
US20080139565A1,COC(=O)c1ccccc1NC(=O)OCc1ccc(-c2ccccc2)cc1>>O=C(Nc1ccccc1C(=O)O)OCc1ccc(-c2ccccc2)cc1,,C1COCCO1,,[Na+].[OH-],,val
US20110065706A1,Brc1cnccc1COc1cnc(N2CCNCC2)nc1.N#CBr>>N#CN1CCN(c2ncc(OCc3ccncc3Br)cn2)CC1,,ClCCl,ClCCl,CCN(CC)CC,,val
US04904646,Fc1ccc(CBr)cc1.O=Cc1c(O)cc(Cl)cc1Cl>>O=Cc1c(Cl)cc(Cl)cc1OCc1ccc(F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070259890A1,COc1ccc(-c2cc(-c3ccc(OC)cc3)nc(C)n2)cc1.O=C1CCC(=O)N1Br>>COc1ccc(-c2cc(-c3ccc(OC)cc3)nc(CBr)n2)cc1,,ClC(Cl)(Cl)Cl,ClCCl,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20050176784A1,BrCc1ccc(Br)nc1.N#CC(C#N)CCC(F)(F)F>>N#CC(C#N)(CCC(F)(F)F)Cc1ccc(Br)nc1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150344407A1,O=[N+]([O-])c1ccc(/C(=C\CO)c2ccccc2)cc1>>O=C/C=C(/c1ccccc1)c1ccc([N+](=O)[O-])cc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20030199691A1,CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=Cc1c(Cl)cc(CO)cc1Cl>>CCCC(C)C.CCOC(C)=O,,ClCCl,,,,val
US20100298340A1,CC(C)(C)OC(=O)NC(=N)Nc1nc(C(=O)O)cs1.CCn1c2ccccc2c2cc(N)ccc21>>CCn1c2ccccc2c2cc(NC(=O)c3csc(NC(=N)N)n3)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20070003539A1,CC(=O)O.CCS(=O)(=O)c1ccc([N+](=O)[O-])cc1C#N>>CCS(=O)(=O)c1ccc(NC(C)=O)cc1C#N,[Fe],,,CC(=O)OC(C)=O,,val
US20150307452A1,CC(C)(C)OC(=O)NC1(CC(N)=O)CCN(C(=O)OCc2ccccc2)C1.Cl>>Cl.NC(=O)CC1(N)CCN(C(=O)OCc2ccccc2)C1,,C1COCCO1,,,,val
US20110288090A1,CCOC(=O)Cc1ccccc1.Nc1ncnc(Cl)c1C=O>>Oc1nc2ncnc(Cl)c2cc1-c1ccccc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20130085127A1,O=S(Cl)Cl.OC(c1ccccc1)c1ccc(F)cc1>>Fc1ccc(C(Cl)c2ccccc2)cc1,,ClCCl,,,,val
US20140066453A1,CC[Mg]Br.COc1ccc(/C=N/[S@@](=O)C(C)(C)C)cc1F>>CC[C@@H](N[S@@](=O)C(C)(C)C)c1ccc(OC)c(F)c1,,C1CCOC1,CCOC(C)=O,[Cl-].[NH4+],,val
US20100113776A1,CO.O=[N+]([O-])c1cnn(-c2ccc(OC3CCN(C4CCC4)CC3)cc2)c1>>Nc1cnn(-c2ccc(OC3CCN(C4CCCC4)CC3)cc2)c1,[Pd],,,,,val
US20040102636A1,CC(C)(C)c1ccc(OC2CCOC2)c([N+](=O)[O-])c1>>CC(C)(C)c1ccc(OC2CCOC2)c(N)c1,[Pd],CCOC(C)=O,,,,val
US20060128790A1,C1CCNC1.CC(=O)Oc1c(C)cc(O)c(C(C)=O)c1C.CCOC(C)=O.Cc1ccccc1.O.O=C1CCC1>>CC(=O)Oc1c(C)cc2c(c1C)C(=O)CC1(CCC1)O2.Cc1cc2c(c(C)c1O)C(=O)CC1(CCC1)O2,,CCOC(C)=O,Cc1ccccc1,,,val
US20080125425A1,CCCn1c(=O)c2[nH]c(-c3ccc(Cl)nc3)cc2n(CCC)c1=O.NCC1CCCO1>>CCCn1c(=O)c2[nH]c(-c3ccc(NCC4CCCO4)nc3)cc2n(CCC)c1=O,,CCO,,,,val
US06809199B2,O=C1CCc2c(-c3ccc(F)cc3F)cc(O)cc2N1c1c(Cl)cccc1Cl.OCCN1CCCCC1>>O=C1CCc2c(-c3ccc(F)cc3F)cc(OCCN3CCCCC3)cc2N1c1c(Cl)cccc1Cl,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05719141,NC(=O)COc1ccccc1[N+](=O)[O-]>>NC(=O)COc1ccccc1N,[Pd],C1CCOC1,,,,val
US04209521,C=O.Cc1cc2ccccc2[nH]1.O=C(NC(=O)c1ccccc1)NC1CCNCC1>>Cc1[nH]c2ccccc2c1CN1CCC(NC(=O)NC(=O)c2ccccc2)CC1,,CC(=O)O,O,,,val
US05622976,CCOC(=O)c1nnc(-c2ccc(SC)cc2)o1.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)c1nnc(-c2ccc(S(C)=O)cc2)o1,,ClC(Cl)Cl,,,,val
US20090137561A1,COC(=O)c1ccc(-c2cc(OC)ccc2F)c(C2=C[C@H]3CC[C@]2(C)C3(C)C)c1>>COc1ccc(F)c(-c2ccc(CO)cc2C2=C[C@H]3CC[C@]2(C)C3(C)C)c1,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20140171430A1,CC(C)(C)OC(=O)N1CC2CNCC2C1.COC(=O)c1cc(C)nc(Cl)n1>>COC(=O)c1cc(C)nc(N2CC3CN(C(=O)OC(C)(C)C)CC3C2)n1,,CC#N,,,,val
US20160002225A1,C=O.COc1ccc(Cn2nc(N[C@@H]3CCNC3)c3c(Oc4ccc(Oc5ccccc5)cc4)ccnc32)cc1>>COc1ccc(Cn2nc(N[C@@H]3CCN(C)C3)c3c(Oc4ccc(Oc5ccccc5)cc4)ccnc32)cc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05665718,CCOC(=O)c1ncn2c1[C@@H]1CCCN1C(=O)c1sccc1-2.NN>>NNC(=O)c1ncn2c1[C@@H]1CCCN1C(=O)c1sccc1-2,,CCO,,O,,val
US20070259854A1,C1CCCn2c(nnc2C2(C3CCNCC3)CCCC2)CC1.OCn1ccnn1>>CN1CCC(C2(c3nnc4n3CCCCCC4)CCCC2)CC1,,CO,,[BH4-].[Na+],,val
US20100298340A1,COC(=O)c1ccc(/C=C(\C)[N+](=O)[O-])cc1.OO>>COC(=O)c1ccc(C2OC2(C)[N+](=O)[O-])cc1,,CO,,Cl,[Na+].[OH-],val
US20140100154A1,COc1ccc(CO)cc1.O=C1CCC(=O)O1>>COc1ccc(COC(CC=O)C(=O)O)cc1,CN(C)c1ccncc1,CC#N,O,O=C([O-])[O-].[Na+].[Na+],,val
US20140031360A1,CC(C)(C)OC(=O)N1CCC2(CC2)[C@@H](Oc2cncc(-c3n[nH]c4ccc(C(C)(C)CO)cc34)n2)C1.CO>>CC(CO)c1ccc2c(c1)c(-c1cncc(O[C@H]3CNCCC34CC4)n1)nn2C,,CO,ClCCl,O=C(O)C(F)(F)F,,val
US20080167310A1,CCOC(=O)C(C)(C)Oc1ccc(OCc2ccccc2)cc1CNC(=O)OC(C)(C)C>>CCOC(=O)C(C)(C)Oc1ccc(O)cc1CNC(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20110294800A1,COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2.N>>COc1cc2c(cc1OC)C1CC(N)C(CC(C)C)CN1CC2,,CO,,CC(=O)O,[BH4-].[Na+],val
US20070185089A1,CC(C)(C)OC(=O)c1ccc(N2CCC(c3ccc4c(c3)CCN(C3CCC3)CC4)CC2)cn1>>O=C(O)c1ccc(N2CCC(c3ccc4c(c3)CCN(C3CCC3)CC4)CC2)cn1,,O=C(O)C(F)(F)F,,O,,val
US20040220188A1,Cc1ccc(N2NC(=O)CC2=O)cc1Cl.O=Cc1ccco1>>Cc1ccc(N2NC(=O)C(=Cc3ccco3)C2=O)cc1Cl,c1ccncc1,CCO,,,,val
US20070010556A1,CCOC(=O)[C@H](C#N)NC(=O)c1ccccc1>>CCOC(=O)c1nc(-c2ccccc2)oc1N,,C1COCCO1,,Cl,,val
US20080090801A1,CNc1nc(C)c2cc(C(=O)O)c(=O)n(C3CCCC3)c2n1.Nc1cc[nH]n1>>CNc1nc(C)c2cc(C(=O)Nc3cc[nH]n3)c(=O)n(C3CCCC3)c2n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04575378,CCCN.O=[N+]([O-])c1cc(O)ccc1Cl>>CCCNc1ccc(O)cc1[N+](=O)[O-],,O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20110190255A1,FC(F)(F)c1c(-c2ccccc2)noc1-c1nc(-c2ccc(C3CO3)cc2)no1.OCCC1CCCNC1>>OCCC1CCCN(CC(O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1,,CC(C)O,,CS(C)=O,,val
US03963777,C=CCN1C(=O)CN=C(c2ccccc2F)c2cc(Cl)ccc21.O=C(OO)c1cccc(Cl)c1>>C=CCN1C(=O)C[N+]([O-])=C(c2ccccc2F)c2cc(Cl)ccc21,,ClC(Cl)Cl,,,,val
US20070032478A1,CC(=O)c1ccc(C(=O)Nc2ccc(C(=O)c3ccc4c(c3)NC(=O)C4=CO)cc2)s1.Nc1cccc(O)c1>>CC(=O)c1ccc(C(=O)Nc2ccc(C(=O)c3ccc4c(c3)NC(=O)C4=CNc3cccc(O)c3)cc2)s1,,C1CCOC1,,,,val
US20080033006A1,CCc1cccc(C)c1CNc1cc(C(=O)OC)cn2nc(C)nc12>>CCc1cccc(C)c1CNc1cc(CO)cn2nc(C)nc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050282851A1,COc1ccc2nc(N)sc2n1.CS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)Cl)cc1>>COc1ccc2nc(NC(=O)C(CC3CCCC3)c3ccc(S(C)(=O)=O)cc3)sc2n1,,c1ccncc1,,,,val
US05362878,CCCCCCCCCC1(C(=O)Cl)CCc2ccccc2C1.COc1cc(OC)c(N)c(OC)c1>>CCCCCCCCCC1(C(=O)Nc2c(OC)cc(OC)cc2OC)CCc2ccccc2C1,CN(C)c1ccncc1,ClCCl,,,,val
US05405851,COC(=O)c1ccc(S(=O)(=O)Nc2ccc3ccc4nc(N)[nH]c(=O)c4c3c2)cc1>>Nc1nc2ccc3ccc(NS(=O)(=O)c4ccc(C(=O)O)cc4)cc3c2c(=O)[nH]1,,[Na+],[OH-],Cl,,val
US20010051632A1,COc1ccc(-c2cn3ccccc3c2-c2ccccc2)cc1>>Oc1ccc(-c2cn3ccccc3c2-c2ccccc2)cc1,,CC(=O)O,,Br,,val
US20130224186A1,CC(=O)O[C@@H](C)C(=O)Cl.CC(C)(C)C(NC[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1F)c1nc(-c2cc(F)ccc2F)oc1Cc1ccccc1>>CC(=O)O[C@@H](C)C(=O)N(C[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1F)[C@@H](c1nc(-c2cc(F)ccc2F)oc1Cc1ccccc1)C(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05484689,CCc1ccccc1.O=CC(=O)c1ccccc1>>CCc1ccc(C(O)C(=O)c2ccccc2)cc1,Cl[Ti](Cl)(Cl)Cl,CC(Cl)Cl,,O,,val
US09248117B2,CC1(C)NC(=O)C(C)(C)N1.OCC1CO1>>CC1(C)NC(C)(C)N(CC(O)CO)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20080167345A1,COC(=O)c1cccc(C=O)c1[N+](=O)[O-].Nc1ccccc1>>COC(=O)c1cccc(C=Nc2ccccc2)c1[N+](=O)[O-],,CCO,,CCCCCC,CCOC(C)=O,val
US05631280,COC(=O)c1cccc(NC[C@H](CSC(c2ccccc2)(c2ccccc2)c2ccccc2)NC(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)N[C@H](CNc1cccc(C(=O)O)c1)CSC(c1ccccc1)(c1ccccc1)c1ccccc1,,CO,,[Na+].[OH-],,val
US20140171420A1,CC(C)c1c(N2CCC(Br)C2=O)cnn1-c1ccc(F)cc1.FC(F)(F)c1c[nH]cn1>>CC(C)c1c(N2CCC(n3cnc(C(F)(F)F)c3)C2=O)cnn1-c1ccc(F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130253029A1,CCON=CC1C2CN(C(=O)OC(C)(C)C)CC12c1ccc(Cl)c(Cl)c1.Cl>>CCON=CC1C2CNCC12c1ccc(Cl)c(Cl)c1.Cl,,ClCCl,,CCCCCC,,val
US20110130594A1,O=C1c2cc3ccccc3cc2C(=O)c2cc3ccccc3cc21>>O[C@H]1c2cc3ccccc3cc2[C@H](O)c2cc3ccccc3cc21,,CO,,[BH4-].[Na+],,val
US20080139631A1,N#Cc1ccc2c(ccn2Cc2noc(-c3cccc(C(F)(F)F)c3)n2)c1C(F)(F)F>>N#Cc1ccc2c(c1C(F)(F)F)CCN2Cc1noc(-c2cccc(C(F)(F)F)c2)n1,,O=C(O)C(F)(F)F,,[BH3-]C#N.[Na+],,val
US20110021493A1,CN1CCC2CNCC21.O=C(/C=C/CCl)N1CCc2c(sc3ncnc(Nc4ccc(Cl)c(Cl)c4)c23)C1>>CN1CCC2CN(C/C=C/C(=O)N3CCc4c(sc5ncnc(Nc6ccc(Cl)c(Cl)c6)c45)C3)CC21,,CN(C)C=O,,,,val
US20110245257A1,CNC(=O)c1cccc2nc([C@H](C)N)n(C3CC3)c12.Nc1nnc(Br)s1>>CNC(=O)c1cccc2nc([C@H](C)Nc3nnc(N)s3)n(C3CC3)c12,,CCO,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070293530A1,NCCCCCN1C(=O)c2ccccc2Oc2ccccc21.NS(N)(=O)=O>>NS(=O)(=O)NCCCCCN1C(=O)c2ccccc2Oc2ccccc21,,C1COCCO1,,,,val
US20100256361A1,Nc1nc(-c2ccco2)c(C(=O)c2ccccn2)s1.O=C(n1ccnc1)n1ccnc1>>O=C=Nc1nc(-c2ccco2)c(C(=O)c2ccccn2)s1,,ClCCl,,CCCCCC,,val
US20140343092A1,COC(=O)c1c(-c2ccc(C)cc2)c2c3ccccc3n(Cc3ccc(F)cc3)c2c(=O)n1C>>Cc1ccc(-c2c(C(=O)O)n(C)c(=O)c3c2c2ccccc2n3Cc2ccc(F)cc2)cc1,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US20130045169A1,CCN(CC)CC.O=C(Cl)C(=O)Cl.OCCCCCCCCCBr>>BrCCCCCCCCC1OCCO1,,ClCCl,,CS(C)=O,,val
US20080045506A1,CC(C)N1CCN(C(=O)[C@H]2CCN(C(=O)OC(C)(C)C)C2)CC1>>CC(C)N1CCN(C(=O)[C@H]2CCNC2)CC1,,C1COCCO1,CO,Cl,,val
US20150038438A1,Cn1ccc2cc3c(c(F)c21)C=CCCC3=O>>Cn1ccc2cc3c(c(F)c21)CCCCC3=O,[Pd],CCOC(C)=O,,,,val
US20160137637A1,CN(C)C(=O)c1ccc2[nH]c(N)nc2c1.O=C(O)c1csc(-c2ccc3c(c2)CCO3)n1>>CN(C)C(=O)c1ccc2[nH]c(NC(=O)c3csc(-c4ccc5c(c4)CCO5)n3)nc2c1,CN(C)c1ccncc1,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160272621A1,CC(C)(C)OC(=O)Nc1cnc(Cl)cc1C1(O)CCOCC1>>Nc1cnc(Cl)cc1C1(O)CCOCC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100197697A1,C1CCNCC1.CC(Cl)OC(=O)Cl.CCN(C(C)C)C(C)C.C[C@@H](O)[C@H]1CCN(Cc2ccccc2)C[C@@H]1c1ccc(Cl)cc1.C[C@H](Oc1ccc(Cl)c(Cl)c1)[C@H]1CCN(C(=O)C2CCN(c3ccc(C#N)cn3)CC2)C[C@@H]1c1ccc(Cl)cc1.Oc1cccc(F)c1>>C[C@H](Oc1cccc(F)c1)[C@H]1CCN(C(=O)C2CCN(c3ccc(C#N)cn3)CC2)C[C@@H]1c1ccc(Cl)cc1.N#Cc1ccc(N2CCC(C(=O)O)CC2)nc1,,CO,,,,val
US20130012554A1,O=[N+]([O-])c1ccc(N2CC3CC(O)CC3C2)c(F)c1>>O=C1CC2CN(c3ccc([N+](=O)[O-])cc3F)CC2C1,,ClCCl,,CCN(CC)CC,,val
US20050227987A1,CC(=O)c1ccc(N)cc1.CCCc1ccc(C(=O)Cl)cc1>>CCCc1ccc(C(=O)Nc2ccc(C(C)=O)cc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20110178132A1,N#Cc1cc(Cl)ccn1.OB(O)c1ccccc1C(F)(F)F>>N#Cc1cc(-c2ccccc2C(F)(F)F)ccn1,,C1COCCO1,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US04843068,CCSC(=O)c1ccc(CCl)cc1.Cc1nn(C)c(Oc2ccccc2)c1C=NO>>CCSC(=O)c1ccc(CON=Cc2c(C)nn(C)c2Oc2ccccc2)cc1,,CS(C)=O,,O,[K+].[OH-],val
US20110190290A1,CO.O=C(O)c1n[nH]c2ncccc12>>COC(=O)c1n[nH]c2ncccc12,O=S(=O)(O)O,,,,,val
US05248672,Br.Nc1nc2cc(Cl)c(Cl)cc2[nH]1>>Clc1cc2nc(Br)[nH]c2cc1Cl,,O,,O=N[O-].[Na+],,val
US20120289500A1,COC(=O)c1ccccc1C(=O)c1cccs1.NN>>O=c1[nH]nc(-c2cccs2)c2ccccc12,,CCO,,O,,val
US20060270724A1,CCOC(=O)C[C@@H](c1ccc(OCc2cccc(-c3ccc(Cl)cc3C)c2)cc1)c1nccn1C>>Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1,,CCO,,Cl,[Na+].[OH-],val
US20140024649A1,O=C(O)C(Cc1ccc(Br)cc1)C(=O)O>>O=C(O)CCc1ccc(Br)cc1,,CS(C)=O,,,,val
US04031221,O=C(C(=O)N1CC(Oc2ccc(F)cc2)C1)c1c[nH]c2ccccc12>>Fc1ccc(OC2CN(CCc3c[nH]c4ccccc34)C2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050245572A1,CN1CCC(CO)(c2ccc(F)cc2)CC1.O=C(O)c1cc(Br)cc2ccccc12>>CN1CCC(COC(=O)c2cc(Br)cc3ccccc23)(c2ccc(F)cc2)CC1,CN(C)C=O,ClCCCl,ClCCl,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20120149683A1,CN(C)/C=C1/CN(C(=O)OC(C)(C)C)CC1=O.NN>>CC(C)(C)OC(=O)N1Cc2c[nH]nc2C1,,CCO,,,,val
US20120214791A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.Cc1ccc(-c2c(I)cnn2C)cc1>>CC(=O)c1cnn(C)c1-c1ccc(C)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,[Cl-].[Li+],,val
US03962440,Cn1c(=O)cnc2ccc(C(F)(F)F)cc21.OO>>Cn1c(=O)c(=O)[nH]c2ccc(C(F)(F)F)cc21,,CC(=O)O,,,,val
US05709911,Fc1cccc([C@@H]2CC[C@@H](C=CCCCCCOCc3ccccc3)CC2)c1F>>OCCCCCCC[C@@H]1CC[C@@H](c2cccc(F)c2F)CC1,,CCO,,,,val
US20090042929A1,Cc1c(C(=O)CBr)sc2ccc(Cl)cc12.SCc1ccc(Cl)cc1>>Cc1c(C(=O)CSCc2ccc(Cl)cc2)sc2ccc(Cl)cc12,,CC#N,CCN(CC)CC,,,val
US04985427,CN=C=O.COC(=O)CN(N)c1cccc(C(F)(F)F)c1>>CN1C(=O)CN(c2cccc(C(F)(F)F)c2)NC1=O,,CO,,C[O-].[Na+],,val
US20090281079A1,N#Cc1ccc[nH]1.O=C(Cl)C(Cl)(Cl)Cl>>N#Cc1cc(C(=O)C(Cl)(Cl)Cl)c[nH]1,,CCOC(C)=O,ClCCl,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100004261A1,CI.O=C(Nc1ccccc1)N1CCN(Cc2ccc(Br)c(Br)c2)CC1>>CN(C(=O)N1CCN(Cc2ccc(Br)c(Br)c2)CC1)c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20110230490A1,FC1(F)Oc2ccc(CC3CCCNC3)cc2O1.O=C(Nc1cccnc1)Oc1ccccc1>>O=C(Nc1cccnc1)N1CCCC(Cc2ccc3c(c2)OC(F)(F)O3)C1,,CC#N,,CCN(CC)CC,Cl,val
US04146630,CCOC(=O)c1cc2c(O)cccc2[nH]1.c1ccc(OCC2CCN(CC3CO3)CC2)cc1>>CCOC(=O)c1[nH]c2ccccc2c1OCC(O)CN1CCC(COc2ccccc2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05444084,CC(=O)OC(C)=O.CC(C)(C)C#C/C=C/C/C(=C\CCCCOc1cccc(-c2ccsc2)c1)CO>>CC(=O)OC/C(=C/CCCCOc1cccc(-c2ccsc2)c1)C/C=C/C#CC(C)(C)C,,c1ccncc1,,,,val
US05763450,COc1cc(C=O)cc(-c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)c1OC.N#CCCNc1ccccc1>>COc1cc(CC(C#N)=CNc2ccccc2)cc(-c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)c1OC,,CS(C)=O,O,Cl,CC(C)(C)[O-].[K+],val
US20080221358A1,CCBr.O=Cc1cccc(F)c1>>CCC(O)c1cccc(F)c1,,C1CCOC1,,[Mg],,val
US20050227987A1,COc1ccc(C(=O)Cl)cc1.Nc1ccc(C(=O)c2ccccc2)cc1>>COc1ccc(C(=O)Nc2ccc(C(=O)c3ccccc3)cc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20050101650A1,CCOC(=O)c1cc(N)cn1S(C)(=O)=O.O=Cc1cccc(F)c1F>>CCOC(=O)c1cc(N=Cc2cccc(F)c2F)cn1S(C)(=O)=O,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080275085A1,CC(C)(C)OC(=O)N1CCC(C(=O)OCc2ccccc2)CC1.Cl>>Cl.O=C(OCc1ccccc1)C1CCNCC1,,CCOC(C)=O,,,,val
US20150252030A1,COC(=O)CBr.Cc1cc(C)c(S)c(C)c1>>COC(=O)CSc1c(C)cc(C)cc1C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100069287A1,CC(C)(C)c1cccc(CCC=O)c1.OCCO>>CC(C)(C)c1cccc(CCC2OCCO2)c1,,C1CCCCC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080039462A1,CC(=O)Oc1cn(C(C)=O)c2ccccc12.CC(C)(C)OC(=O)N1CCNCC1>>CC(=O)n1cc(N2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US08450342B2,CC(C)Br.Clc1cc(Cl)c2[nH]cnc2n1>>CC(C)n1cnc2c(Cl)cc(Cl)nc21,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160272602A1,Cc1cccc(CO)c1Br>>Cc1cccc(C=O)c1Br,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20070066647A1,CCOC(=O)C[Si](C)(C)C.O=C(c1ccc(OC2CCCCO2)cc1)c1cnco1>>CCOC(=O)C=C(c1ccc(OC2CCCCO2)cc1)c1cnco1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US04880809,COc1cc(C(=O)Cl)cc(OC)c1OC.COc1cc2c(cc1OC)CCCC(C(=O)N1CCNCC1)=C2>>COc1cc2c(cc1OC)CCCC(C(=O)N1CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)CC1)=C2,,ClCCl,,CCN(CC)CC,,val
US05629406,CC(C)(C)OC(=O)N1CC[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1COCc1ccccc1>>CC(C)(C)OC(=O)N1CC[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1CO,[Pd],CO,,O=CO,,val
US20090181402A1,CC(C)(Br)C(=O)Br.[N-]=[N+]=NCCOCCOCCO>>CC(C)(Br)C(=O)OCCOCCOCCN=[N+]=[N-],,C1CCOC1,,CCN(CC)CC,,val
US05156918,C=CCN(CC=C)c1ccccc1C=O.C=CCNCC=C.O=Cc1ccc(F)cc1>>C=CCN(CC=C)c1ccc[n+]([O-])c1C=Cc1ccccc1,,CO,CS(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20080207882A1,COc1ccc(Cc2sccc2OC2OC(COC(C)=O)C(OC(C)=O)C(OC(C)=O)C2OC(C)=O)cc1>>COc1ccc(Cc2sccc2OC2OC(CO)C(O)C(O)C2O)cc1,,CC(=O)O,,CO,C[O-].[Na+],val
US20140200197A1,COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H]1CN[C@H](Cn2cc([Si](C)(C)C)nn2)CO1)C(c1ccccc1)c1ccccc1>>COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H]1CN[C@H](Cn2ccnn2)CO1)C(c1ccccc1)c1ccccc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080312208A1,Cc1nc(N2CCC(C(=O)OC(C)(C)C)CC2)c(C#N)cc1C(=O)OCC(C)(C)C>>Cc1nc(N2CCC(C(=O)O)CC2)c(C#N)cc1C(=O)OCC(C)(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060128695A1,CCCCC#Cc1cccc(C2=NCC(=O)N(C)c3cc(OC)c(OC)cc32)c1>>CCCCCCc1cccc(C2=NCC(=O)N(C)c3cc(OC)c(OC)cc32)c1,[Pd],CO,,ClCCl,,val
US04118510,O=C(O)C1C2(CCCC2)C12CC2.O=C1C2=C(CCCC2)C(=O)N1CO>>O=C(OCN1C(=O)C2=C(CCCC2)C1=O)C1C2(CCCC2)C12CC2,,CCOCC,c1ccccc1,CCN(CC)CC,O=S(Cl)Cl,val
US05478838,COC(=O)C1CCC(C(C)NC(C)=O)CC1>>COC(=O)[C@@H]1CC[C@@H](C(C)NC(C)=O)CC1,,CO,,Cl,CC(C)(C)[O-].[K+],val
US20160009744A1,CC(C)[Si](O[C@H]1C[C@H](Nc2ncncc2C(=O)c2cc(CC3=CCCCC3)cs2)C[C@@H]1COS(N)(=O)=O)(C(C)C)C(C)C>>NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ncncc2C(=O)c2cc(CC3=CCCCC3)cs2)C[C@@H]1O,,C1CCOC1,,Cl,,val
US20020010176A1,CCOC(C)=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CN1CCOCC1.F[P-](F)(F)(F)(F)F.O=C(O)C[C@H](NCc1ccc2c(n1)NCCC2)c1cccc(F)c1>>CCOC(=O)C[C@H](NC(=O)C[C@H](NCc1ccc2c(n1)NCCC2)c1cccc(F)c1)c1cccc(F)c1,,CC#N,,,,val
US20140112945A1,COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](NC(=O)OC(C)(C)C)C4CCCCC4)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl>>COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](N)C4CCCCC4)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl,,C1COCCO1,,,,val
US20160115126A1,Cc1[nH]c2c(C(N)=O)cc(F)c(Br)c2c1C>>Cc1[nH]c2c(C#N)cc(F)c(Br)c2c1C,,C1CCOC1,,O=P(Cl)(Cl)Cl,,val
US20070191364A1,CCN(CC)C(=O)N(C1CCCCCC1)C1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N[C@@H]2CC[C@H](N)CC2)CC1.Cl>>CCN(CC)C(=O)N(C1CCCCCC1)C1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N[C@@H]2CC[C@H](N)CC2)CC1.Cl,,CCOCC,,,,val
US20160108041A1,CC(C)(CON)O[Si](C)(C)C(C)(C)C.CCOC(=O)c1c2c(c(=O)n(C)c1Nc1ccc(I)cc1F)CCC2>>Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOCC(C)(C)O[Si](C)(C)C(C)(C)C)c2c(c1=O)CCC2,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05892106,CC(N)c1ccccc1.COc1ccc(Cl)cc1C(F)(C(=O)O)c1ccc(C(F)(F)F)cc1[N+](=O)[O-]>>COc1ccc(Cl)cc1[C@](F)(C(=O)O)c1ccc(C(F)(F)F)cc1[N+](=O)[O-].C[C@H](N)c1ccccc1,,CC(C)O,,,,val
US20070010511A1,CCOC(=O)CCl.COCCCOc1cccc(C=O)c1O>>CCOC(=O)c1cc2cccc(OCCCOC)c2o1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04232039,COC(=O)Cc1cc(Cl)c(C2CCCCC2)cc1OC>>COc1cc(C2CCCCC2)c(Cl)cc1CCO,,C1CCOC1,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20100210680A1,CC(C)(C)OC(=O)N1C[C@@H]2OCc3cc(OCc4ccccc4)ccc3[C@@H]2C1>>CC(C)(C)OC(=O)N1C[C@@H]2OCc3cc(O)ccc3[C@@H]2C1,[Pd],CCO,,,,val
US20120059030A1,CCOC(=O)C1(Oc2cc(F)c(F)c(F)c2)CCCN(Cc2ccc(OC)cc2)C1=O>>COc1ccc(CN2CCCC(Oc3cc(F)c(F)c(F)c3)C2=O)cc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20160122342A1,C=CCc1c(N[C@@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)cccc1C(=O)OC.CC=O>>C=CCc1c(C(=O)OC)cccc1N(CC)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1,,ClCCCl,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100256156A1,COC(=O)c1c[nH]cc1C.FC(F)(F)c1cccc(I)c1>>COC(=O)c1cn(-c2cccc(C(F)(F)F)c2)cc1C,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20160264578A1,CC(=O)O.COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(N)cc4)cn3n(Cc3c(F)cccc3F)c2=O)nn1.ClCCl.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CNC(=O)Nc1ccc(-c2cn3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2F)cc1,,Cc1ccccc1,ClCCl,CCN(C(C)C)C(C)C,,val
US20130237502A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(N)(CO)c1ccc(Br)cn1>>CC(C)(C)OC(=O)NC(C)(CO)c1ccc(Br)cn1,,ClCCl,,CCN(CC)CC,,val
US20050187236A1,CCC(CC)NC(=O)Oc1ccccc1.Nc1cc(Oc2ccc3[nH]ccc3c2)ccn1>>CCC(CC)NC(=O)n1ccc2cc(Oc3ccnc(N)c3)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20090023763A1,Nc1nc(-c2ccco2)c(-c2ccncc2)cc1[N+](=O)[O-]>>Nc1cc(-c2ccncc2)c(-c2ccco2)nc1N,[Pd],CCO,,,,val
US20130040949A1,CCN1CCN(Cc2ccc(C(=O)Nc3ccc(C)c(N)c3)cc2C(F)(F)F)CC1.Cc1ccc(S(=O)(=O)n2ccc3c(Cl)c(C(=O)O)cnc32)cc1>>CCN1CCN(Cc2ccc(C(=O)Nc3ccc(C)c(NC(=O)c4cnc5c(ccn5S(=O)(=O)c5ccc(C)cc5)c4Cl)c3)cc2C(F)(F)F)CC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070270422A1,CCOC(=O)CCc1ccc(Nc2ccc([N+](=O)[O-])cn2)c(OC)c1.CI>>CCOC(=O)CCc1ccc(N(C)c2ccc([N+](=O)[O-])cn2)c(OC)c1,,CN(C)C=O,,[H-].[Na+],,val
US20060247178A1,CC(C)(C)[Si](OCCC1(c2ccccc2)SC(c2cc(F)ccc2F)=NN1C(=S)NC(=O)c1ccccc1)(c1ccccc1)c1ccccc1>>CC(C)(C)[Si](OCCC1(c2ccccc2)SC(c2cc(F)ccc2F)=NN1C(N)=S)(c1ccccc1)c1ccccc1,,C1CCOC1,,NN,,val
US20120263679A1,Nc1ccc(Br)cc1F.O=C(O)c1ccc(Cl)nc1Cl>>O=C(O)c1ccc(Cl)nc1Nc1ccc(Br)cc1F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20080194681A1,CC(=O)c1ccc(N)cc1.FC(F)(F)Oc1ccc(CBr)cc1>>CC(=O)c1ccc(NCc2ccc(OC(F)(F)F)cc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05958821,CC(=O)O.Cc1ccc(C)cc1.O=C1c2ccccc2C(=O)N1O.O=O>>Cc1ccc(C(=O)O)cc1.O=C(O)c1ccc(C(=O)O)cc1,,Cc1ccc(C)cc1,,,,val
US05202321,C=[N+]=[N-].CC(C)(Cc1cc2cc(O)ccc2n1Cc1ccc(Cl)cc1)C(=O)O>>COC(=O)C(C)(C)Cc1cc2cc(O)ccc2n1Cc1ccc(Cl)cc1,,CCOCC,,,,val
US20070299085A1,Cc1cc(CCl)ccc1[N+](=O)[O-].O=C(c1cc(I)c[nH]1)C(F)(F)F>>Cc1cc(Cn2cc(I)cc2C(=O)C(F)(F)F)ccc1[N+](=O)[O-],,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20150232463A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc(C)c(-c2ccc(O)cc2)c1N1CCC(C)(C)CC1.OCCCc1ccc(F)cc1>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc(C)c(-c2ccc(OCCCc3ccc(F)cc3)cc2)c1N1CCC(C)(C)CC1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060189623A1,CS(=O)(=O)CCOS(C)(=O)=O.N#Cc1cnc(C(=O)Nc2ccc(C3CCNCC3)nc2C2=CCCCC2)[nH]1>>CS(=O)(=O)CCN1CCC(c2ccc(NC(=O)c3ncc(C#N)[nH]3)c(C3=CCCCC3)n2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20150111870A1,CC1(C)OC(=O)CC(=O)O1.Nc1ccc(Br)cc1>>O=C(O)CC(=O)Nc1ccc(Br)cc1,,CCOC(C)=O,,,,val
US08829007B2,Cc1ccc(S(=O)(=O)n2cc(B3OC(C)(C)C(C)(C)O3)c3cc(Cl)cnc32)cc1.O[C@H]1[C@@H](Nc2nc(Cl)ncc2F)CCC[C@H]1O>>Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(NC4(O)CCCCC4O)n3)c3cc(Cl)cnc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US04971975,CCBr.OC12CCC[N+](Cc3ccccc3)(CC1)C2.[Cl-]>>CCOC12CCC[N+](Cc3ccccc3)(CC1)C2.[Cl-],,CN(C)C=O,,[H-].[Na+],,val
US20050209291A1,N=C(Sc1ccccc1)c1cccs1.Nc1ccc2nc(N)sc2c1>>N=C(Nc1ccc2nc(N)sc2c1)c1cccs1,,CCOCC,,Br,,val
US20100130446A1,CC(=O)N1CCN[C@@H](C)C1.O=Cc1ccc(-c2ccc(C(CC3CCOCC3)c3ccc(S(=O)(=O)C4CC4)cc3)[nH]2)nc1>>CC(=O)N1CCN(Cc2ccc(-c3ccc(C(CC4CCOCC4)c4ccc(S(=O)(=O)C5CC5)cc4)[nH]3)nc2)[C@@H](C)C1,,CCOC(C)=O,ClCCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20130085142A1,O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.c1nc(C2CC2)cnc1O[C@@H]1C[C@H]2CNCCN2C1>>O=C(Cl)N1CCN2C[C@H](Oc3cnc(C4CC4)cn3)C[C@H]2C1,,ClCCl,,,,val
US20040029886A1,COc1cc(Cl)c(O)c(C(C)=O)c1>>CC(=O)c1cc(O)cc(Cl)c1O,,Br,,,,val
US20140221345A1,CCOC(=O)CBr.OC1CCCCC1>>O=C(O)COC1CCCCC1,,CN(C)C=O,,O,[H-].[Na+],val
US20090286813A1,CCOC(=O)CC#N.NC(=S)Nc1cccc(F)c1>>Nc1cc(=O)[nH]c(=S)n1-c1cccc(F)c1,,CCO,,C,C[O-].[Na+],val
US20140349988A1,COC(=O)[C@H](CSCC(=O)N1CC([N+](=O)[O-])([N+](=O)[O-])C1)NC(C)=O>>CC(=O)N[C@@H](CSCC(=O)N1CC([N+](=O)[O-])([N+](=O)[O-])C1)C(=O)O,,CO,O,Cl,[Li+].[OH-],val
US20110190269A1,COc1cc(Br)ccc1-n1cnc(C)c1.Cc1cc(-c2ccc3c(c2)OCCN3C)c2nc(N)nn2c1>>COc1cc(Nc2nc3c(-c4ccc5c(c4)OCCN5C)cc(C)cn3n2)ccc1-n1cnc(C)c1,,CO,ClCCl,,,val
US05464864,COc1ccc(NN)cc1.O=C1CCC(N2C(=O)c3ccccc3C2=O)CC1>>COc1ccc2[nH]c3c(c2c1)CC(N1C(=O)c2ccccc2C1=O)CC3,,CCO,,Cl,,val
US05739083,CCOC(=O)CC.O=Cc1c(Cl)cc(C(F)(F)F)cc1Cl>>CCOC(=O)C(C)C(O)c1c(Cl)cc(C(F)(F)F)cc1Cl,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20130059845A1,CCOC(OCC)OCC.NN=C(Nc1ccc(Cl)cc1)c1c(-c2ccccc2Cl)nc2ccccn12>>Clc1ccc(-n2cnnc2-c2c(-c3ccccc3Cl)nc3ccccn23)cc1,,CN(C)C=O,,CC(=O)O,,val
US20120083475A1,NCCc1c[nH]c2ccc(C(F)(F)F)cc12.O=C(O)c1cc(Cc2cc(F)ccc2F)on1>>O=C(NCCc1c[nH]c2ccc(C(F)(F)F)cc12)c1cc(Cc2cc(F)ccc2F)on1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060270646A1,CCCC[Sn](CCCC)(CCCC)c1cccs1.O=S(=O)(c1ccccc1)n1cc(-c2ccoc2)c2cc(Br)cnc21>>O=S(=O)(c1ccccc1)n1cc(-c2ccoc2)c2cc(-c3cccs3)cnc21,Cl[Pd]Cl,Cc1ccccc1,,Cc1ccccc1P(c1ccccc1C)c1ccccc1C,,val
US20130225620A1,Brc1ccc2[nH]cnc2c1.C1=COCCC1>>Brc1ccc2c(c1)ncn2C1CCCCO1,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20030220350A1,Nc1ccc(OC(F)(F)F)c(-c2nc3ccccc3o2)c1.O=C(Cl)OC(Cl)(Cl)Cl>>O=C=Nc1ccc(OC(F)(F)F)c(-c2nc3ccccc3o2)c1,,CCOC(C)=O,Cc1ccccc1,Cl,,val
US20140364432A1,C=CCOC(=O)N1CCC[C@@H](C)[C@H]1CN.FC(F)(F)c1ccc(Cl)nc1>>C=CCOC(=O)N1CCC[C@@H](C)[C@H]1CNc1ccc(C(F)(F)F)cn1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060276464A1,CN(CCNS(=O)(=O)c1cc(S(=O)(=O)c2ccccc2)ccc1C(F)(F)F)C(=O)N[C@H]1CCN(C(=O)OC(C)(C)C)C1.Cl>>CN(CCNS(=O)(=O)c1cc(S(=O)(=O)c2ccccc2)ccc1C(F)(F)F)C(=O)N[C@H]1CCNC1.Cl,,CCOC(C)=O,,,,val
US20050245743A1,CC(C)(C)OC(=O)N1CCC(c2cccc(NC(=O)CCCCCNc3ccc(F)c(F)c3)c2)CC1>>O=C(CCCCCNc1ccc(F)c(F)c1)Nc1cccc(C2CCNCC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04245108,CC(Sc1ccccc1)(C(=O)O)c1cccc(Oc2ccccc2)c1>>CC(C(=O)O)c1cccc(Oc2ccccc2)c1,[Zn],CC(=O)O,,,,val
US20130085144A1,CN1CCN(c2ccc(C(=O)O)c(N(C(=O)C(F)(F)F)C3CCOCC3)c2)CC1>>CN1CCN(c2ccc(CO)c(NC3CCOCC3)c2)CC1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20030114469A1,CC(=O)Cl.COc1cc2cncc(Cc3nc4c([nH]3)c(=O)n(C)c(=O)n4CC(C)CO)c2cc1OC>>COc1cc2cncc(Cc3nc4c([nH]3)c(=O)n(C)c(=O)n4CC(C)COC(C)=O)c2cc1OC,,c1ccncc1,,,,val
US20080287638A1,BrCCCCCOCc1ccc2ccc3cccc4ccc1c2c34.O=C1NC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1CCCCCOCc1ccc2ccc3cccc4ccc1c2c34,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130137679A1,ClCC#CCCl.O=C1CCc2ccc(O)cc2N1>>O=C1CCc2ccc(OCC#CCCl)cc2N1,,CCO,O,O=C([O-])[O-].[K+].[K+],,val
US20030207883A1,CN1CCN(c2ccc3nc(-c4n[nH]c5cccc(N)c45)[nH]c3c2)CC1.O=C(Cl)c1ccccc1>>CN1CCN(c2ccc3nc(-c4n[nH]c5cccc(NC(=O)c6ccccc6)c45)[nH]c3c2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04288449,COC(=O)C1C=C(n2cccc2)C(Cl)=C([N+](=O)[O-])C1=S(=O)=O.Sc1ccccc1>>COC(=O)C1C=C(n2cccc2)C(Sc2ccccc2)=C([N+](=O)[O-])C1=S(=O)=O,,C1CCOC1,,C[O-].[Na+],,val
US05814648,O=C(N[C@@H](CO)c1ccccc1)c1cccc(I)c1>>Ic1cccc(C2=N[C@H](c3ccccc3)CO2)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100093727A1,CS(=O)(=O)OCCCN1CC(O)C2(CC2)C1.Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C>>Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCCCN5CC(O)C6(CC6)C5)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04746352,CC(C)OC(=O)c1cc(-n2c(=O)c3c(n(C)c2=O)CCC3)c(F)cc1Cl>>Cn1c2c(c(=O)n(-c3cc(C(=O)O)c(Cl)cc3F)c1=O)CCC2,,CO,O,Cl,[Na+].[OH-],val
US20020037931A1,COc1cc2c(cc1OC)C(=O)C(C)(C)CC2>>CC1(C)CCc2cc(O)c(O)cc2C1=O,,Br,,,,val
US05013741,Nc1c2c(nc3ccccc13)CCCC2.O=Cc1ccccc1Cl>>Clc1ccccc1C=Nc1c2c(nc3ccccc13)CCCC2,,Cc1ccccc1,,C1COCCN1,,val
US05438064,CCOC(=O)c1cnc2cc(Cl)ccc2c1Cl.Nc1ccc(C(=O)O)cc1>>CCOC(=O)c1cnc2cc(Cl)ccc2c1Nc1ccc(C(=O)O)cc1.Cl,,C1CCOC1,,,,val
US05858995,Cc1oc2c(N)cccc2c1C.Cn1c(=O)oc(=O)c2c(Cl)cccc21>>CNc1cccc(Cl)c1C(=O)Nc1cccc2c(C)c(C)oc12,,CC(=O)O,,,,val
US20100261762A1,CCOP(=O)(CC(=O)C1CCN(C(=O)OC(C)(C)C)C1)OCC.O=C1CCC1>>CC(C)(C)OC(=O)N1CCC(C(=O)C=C2CCC2)C1,,CCO,,[K+].[OH-],,val
US07074801B1,CC(C)(C)C(=O)Cl.Nc1cccc(N2CCN(c3ncnc4ccc(-c5cnn(C(c6ccccc6)(c6ccccc6)c6ccccc6)c5)cc34)CC2)c1>>CC(C)(C)C(=O)Nc1cccc(N2CCN(c3ncnc4ccc(-c5cnn(C(c6ccccc6)(c6ccccc6)c6ccccc6)c5)cc34)CC2)c1,,O,,CCN(CC)CC,CN(C)C=O,val
US20130196969A1,COC(=O)c1ccc2c(-c3ccccc3)cn(C(=O)[O-])c2c1>>COC(=O)c1ccc2c(-c3ccccc3)c[nH]c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080009530A1,COCCCS(N)(=O)=O.O=C(O)/C=C/c1cc(OCC2CC2)nn1Cc1ccc(C(F)(F)F)cc1Cl>>COCCCS(=O)(=O)NC(=O)/C=C/c1cc(OCC2CC2)nn1Cc1ccc(C(F)(F)F)cc1Cl,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US20030073849A1,CNC.O=C(c1c[nH]c2ccc(F)cc12)[C@@H]1C[C@H]1C(=O)O>>CN(C)C(=O)[C@@H]1C[C@H]1C(=O)c1c[nH]c2ccc(F)cc12,,C1CCOC1,,O=C(c1ncc[nH]1)c1ncc[nH]1,,val
US20100179139A1,C1COCCO1.O.O=S(=O)(NC1CCSCC1)c1ccc(Cl)nc1.OB(O)c1ccnc2[nH]c(C(F)(F)F)cc12>>O=CO.O=S(=O)(NC1CCSCC1)c1ccc(-c2ccnc3[nH]c(C(F)(F)F)cc23)nc1,,O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20160016968A1,CC(C)(C)c1nc(-c2cc(Cl)c(C3CC3)cn2)no1.FC1(F)CCNC1>>CC(C)(C)c1nc(-c2cc(N3CCC(F)(F)C3)c(C3CC3)cn2)no1,,O=S1(=O)CCCC1,,Cl,O=C([O-])[O-].[K+].[K+],val
US20050267095A1,CC(C)(C)OC(=O)N1CCC(C#N)(c2ccc(OCCCN3CCCC3)cc2)CC1>>N#CC1(c2ccc(OCCCN3CCCC3)cc2)CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04826866,CCOC(=O)C(Cl)C(C)=O.COc1ccccc1NC(=S)NN>>CCOC(=O)c1c(Nc2ccccc2OC)n[nH]c1C,,CCO,,Cl,,val
US20120208798A1,CCCOC(=O)Cl.CC[C@H]1C[C@@H](N)c2cc(-c3ccc(CN4CCCCC4)cc3)ccc2N1C(C)=O>>CCCOC(=O)N[C@@H]1C[C@H](CC)N(C(C)=O)c2ccc(-c3ccc(CN4CCCCC4)cc3)cc21,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05576335,CCCCCCCN=C=O.Nc1ccncc1N>>CCCCCCCNC(=O)Nc1cnccc1N,CN(C)c1ccncc1,Cc1ccccc1,,,,val
US05807859,O=c1[nH]c2c3ccccc3c(=Cc3cccc([N+](=O)[O-])c3)c2n2ccnc12>>Nc1cccc(CC2c3ccccc3-c3[nH]c(=O)c4nccn4c32)c1,[Pd],CN(C)C=O,,,,val
US20080176870A1,N#CCC(=O)O.Nc1ccccc1Cl>>N#CCC(=O)Nc1ccccc1Cl,CCN(CC)CC,C1CCOC1,ClCCl,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20030176477A1,O=C(Cl)c1snc(Cl)c1Cl.O=C1CC(c2ccc(Cl)cc2)NN1>>O=C1CC(c2ccc(Cl)cc2)NN1C(=O)C1(Cl)NSC=C1Cl,,C1CCOC1,,CN(C)C=O,[H-].[Na+],val
US20100152192A1,BrCC1CCC1.CCOC(=O)c1c(/C=C/c2cccc(OC(F)F)c2O)nc2sccn12>>CCOC(=O)c1c(/C=C/c2cccc(OC(F)F)c2OCC2CCC2)nc2sccn12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030176418A1,CCCCC1CCNCC1.Cc1ccc2c(c1)OCC(=O)N2CCCCl>>CCCCC1CCN(CCCN2C(=O)COc3cc(C)ccc32)CC1,,CCCCCCC,CCOC(C)=O,[I-].[K+],O=C([O-])O.[Na+],val
US05925635,C=CC1CN(c2cccc(C(=N)N)c2)C(=O)N1C1CCNCC1.O=S(=O)(Cl)c1ccccc1>>C=CC1CN(c2cccc(C(=N)N)c2)C(=O)N1C1CCN(S(=O)(=O)c2ccccc2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20140336154A1,CN(C)C1CCNC1.O=C(O)c1ccc2c(c1)-c1sc(-c3ncnn3-c3ccc(F)cc3F)cc1CCO2>>CN(C)[C@H]1CCN(C(=O)c2ccc3c(c2)-c2sc(-c4ncnn4-c4ccc(F)cc4F)cc2CCO3)C1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030013720A1,CC(C)(C)OC(=O)N1CCC(CNC(=O)C(F)(F)F)(c2ccc(I)cc2)CC1.CI>>CN(CC1(c2ccc(I)cc2)CCN(C(=O)OC(C)(C)C)CC1)C(=O)C(F)(F)F,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20110071150A1,CCOC(=O)n1c(-c2cccnc2C)cc2cc(-c3sc(-c4ccccc4)nc3C)ccc21>>Cc1ncccc1-c1cc2cc(-c3sc(-c4ccccc4)nc3C)ccc2[nH]1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US06133284,CCOC(=O)c1cn(-c2nc(NC(C)(C)C)c(F)cc2F)c2c(C)c(F)c(F)cc2c1=O>>Cc1c(F)c(F)cc2c(=O)c(C(=O)O)cn(-c3nc(N)c(F)cc3F)c12,,Cl,,,,val
US20110130406A1,CC=O.COc1ccc(Cn2nc(OCC3CCNCC3)c3c(Oc4ccc(Nc5ncccc5C(=O)Nc5ccc(F)cc5)cc4F)ccnc32)cc1>>CCN1CCC(COc2nn(Cc3ccc(OC)cc3)c3nccc(Oc4ccc(Nc5ncccc5C(=O)Nc5ccc(F)cc5)cc4F)c23)CC1,,ClCCl,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20080096921A1,COC(=O)c1ccc2cc(-c3ccc(OCc4c(COC5CCCC5)noc4C(C)C)cc3)ccc2n1>>CC(C)c1onc(COC2CCCC2)c1COc1ccc(-c2ccc3nc(C(=O)O)ccc3c2)cc1,,C1CCOC1,,CO,[Na+].[OH-],val
US20060281786A1,CC(O)=C(C(=O)OC(C)(C)C)c1cc(Cl)c(Cl)cc1[N+](=O)[O-]>>On1ccc2ccccc21,[Fe],CO,,CCO,O,val
US05025036,BrCCCCCCc1cccc(OCc2ccccc2)c1OCc1ccccc1.O=C(OCc1ccccc1)c1ccc(O)c([N+](=O)[O-])c1>>O=C(OCc1ccccc1)c1ccc(OCCCCCCc2cccc(OCc3ccccc3)c2OCc2ccccc2)c([N+](=O)[O-])c1,,CC(C)=O,CN(C)C=O,[I-].[K+],O=C([O-])O.[Na+],val
US20160220595A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)C(F)(F)F>>CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)NC(=O)C(F)(F)F,CN(C)c1ccncc1,c1ccncc1,,,,val
US20050038043A1,CCCc1c(Cn2ccnc2-c2ncccc2F)ncnc1NN.NC(N)=O>>CCCc1c(Cn2ccnc2-c2ncccc2F)ncn2nc(O)nc12,,CN1CCCC1=O,,Cl,O,val
US20140011796A1,CC[C@@H](C=CC#N)N1C(=O)[C@@H](CC(=O)OC(C)(C)C)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1>>CC[C@@H](CCC#N)N1C(=O)[C@@H](CC(=O)OC(C)(C)C)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1,[Pd],CCO,,[H][H],,val
US20090291937A1,CC(C)(C)OC(=O)NCC1(c2cccc(-c3ccnc4c3c(C(F)(F)F)nn4C(c3ccccc3)(c3ccccc3)c3ccccc3)c2)COC1>>NCC1(c2cccc(-c3ccnc4[nH]nc(C(F)(F)F)c34)c2)COC1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20130317001A1,COC(=O)c1cc(C(C)O[Si](C)(C)C(C)(C)C)c(OCC23CC4CC(CC(C4)C2)C3)cc1F>>CC(O[Si](C)(C)C(C)(C)C)c1cc(C(=O)O)c(F)cc1OCC12CC3CC(CC(C3)C1)C2,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20110201650A1,C#CC1(O)CCC2(CC1)OCCO2.O=Cc1ccc(Cl)cc1>>OC(C#CC1(O)CCC2(CC1)OCCO2)c1ccc(Cl)cc1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20130045169A1,COC(=O)C1(c2ccc(COc3cccc(C(O)c4ccccc4)c3)cc2)CC1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COC(=O)C1(c2ccc(COc3cccc(C(N=[N+]=[N-])c4ccccc4)c3)cc2)CC1,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,,val
US20090099180A1,O=Cc1c(Cl)cc(OCc2ccccc2)cc1Cl>>OCc1c(Cl)cc(OCc2ccccc2)cc1Cl,,CCO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20130231324A1,C1NCC12CNC2.Clc1nnnn1-c1ccccc1>>c1ccc(-n2nnnc2N2CC3(CNC3)C2)cc1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20030134849A1,COc1ccc(B(O)O)cc1.CS(=O)(=O)N1CCC(CC(=O)NOC2CCCCO2)(c2ccc(Br)s2)S(=O)(=O)CC1>>COc1ccc(-c2ccc(C3(CC(=O)NOC4CCCCO4)CCN(S(C)(=O)=O)CCS3(=O)=O)s2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20160115128A1,COC(=O)c1cc(F)c(OC)cc1F>>COc1cc(F)c(C(=O)O)cc1F,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20040122084A1,CC1C(=O)OC2CC3(C)OC3C(OC(=O)c3cccs3)C(N(C)C)C3=CC(OC3=O)C21.Cl>>CC1C(=O)OC2CC3(C)OC3C(OC(=O)c3cccs3)C(N(C)C)C3=CC(OC3=O)C21.Cl,,CC(C)=O,,,,val
US06359138B1,C=CCc1cc(OCc2ccccc2)ccc1O.CC(=O)OC(C)=O>>C=CCc1cc(OCc2ccccc2)ccc1OC(C)=O,,CC(=O)OC(C)=O,,CC(=O)[O-].[Na+],,val
US20070167413A1,CN.CS(=O)(=O)c1ccc(-c2nc(C(F)(F)F)nc(Cl)c2-c2ccc(S(=O)(=O)Cl)cc2)cc1>>CNS(=O)(=O)c1ccc(-c2c(Cl)nc(C(F)(F)F)nc2-c2ccc(S(C)(=O)=O)cc2)cc1,,ClCCl,,,,val
US20090270376A1,O=C(NNC1C2CC3CC1CC(Br)(C3)C2)c1cnc2[nH]ccc2c1Cl>>O=c1[nH]n(C2C3CC4CC2CC(Br)(C4)C3)c2c1cnc1[nH]ccc12,,CN1CCCC1=O,,CCN(CC)CC,O,val
US20150011579A1,COC(=O)c1cc(-c2cc(C(=O)OCc3ccccc3)c3cnn(Cc4ccccc4)c3n2)ccc1F>>COC(=O)c1cc(-c2cc(C(=O)O)c3cnn(Cc4ccccc4)c3n2)ccc1F,,O=S(=O)(O)O,,,,val
US20060160857A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1nc(C)sc1N>>CCOC(=O)c1nc(C)sc1NC(=O)OC(C)(C)C,CN(C)c1ccncc1,C1CCOC1,,,,val
US20160009744A1,CC(C)=O.C[SiH](C)OCc1sc(C2OCCO2)cc1C(O[Si](C)(C)C(C)(C)C)c1cccc(Cl)c1>>CC(C)(C)[Si](C)(C)OCc1sc(C=O)cc1C(O[Si](C)(C)C(C)(C)C)c1cccc(Cl)c1,,CC(C)=O,,,,val
US05399703,COc1cccc(Oc2ccccc2[N+](=O)[O-])c1>>O=[N+]([O-])c1ccccc1Oc1cccc(O)c1,,O,,Cl,c1ccncc1,val
US20100073754A1,COc1cc(OC)c(C(=O)c2ccc(C)cc2)cc1C(=O)c1ccc(C)cc1>>Cc1ccc(C(=O)c2cc(C(=O)c3ccc(C)cc3)c(O)cc2O)cc1,,Cl,,,,val
US04697033,CCC(C)Oc1ccc(O)cc1.O=C1c2ccccc2C(=O)N1CCBr>>CCC(C)Oc1ccc(OCCN2C(=O)c3ccccc3C2=O)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150361067A1,COc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)cc(C(C)C3CN(C(=O)OC(C)(C)C)C3)c(Cl)c2C1=O>>COc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)cc(C(C)C3CNC3)c(Cl)c2C1=O,,ClCCl,,Cl,,val
US20060281772A1,COc1cc2ncnc(C3CCNCC3)c2cc1OC.O=C=Nc1ccccc1>>COc1cc2ncnc(C3CCN(C(=O)Nc4ccccc4)CC3)c2cc1OC,,CN(C)C=O,,,,val
US04898694,CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CC(C)=C(C(C)=O)[C@@]4(C)CC[C@@H]32)C1.NO>>CC(=O)OC1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CC(C)=C(C(C)=NO)[C@@]4(C)CC[C@@H]32)C1,,CCO,c1ccncc1,Cl,O,val
US20120208852A1,N/C(=N\O)C(NC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(C(F)(F)F)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)NC(c1cccc(C(F)(F)F)c1)c1noc(C(F)(F)F)n1,,ClCCl,,CCN(CC)CC,,val
US20060100245A1,CC(C)(C)c1ccc(N)cc1.O=C(O)c1ccc(-c2ncccc2Cl)cc1>>CC(C)(C)c1ccc(NC(=O)c2ccc(-c3ncccc3Cl)cc2)cc1,,CN(C)C=O,O,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20020040017A1,Cn1ccc2c1C(=O)CCN(CCCCl)S2(=O)=O.NO>>Cn1ccc2c1C(=NO)CCN(CCCCl)S2(=O)=O,,CO,,Cl,CC(=O)[O-].[Na+],val
US05077409,CCCCCCCCCCCCCCOc1ccc(CN(C(C)=O)c2ccc(CBr)cc2)cc1.Cc1ccncc1C>>CCCCCCCCCCCCCCOc1ccc(CN(C(C)=O)c2ccc(C[n+]3ccc(C)c(C)c3)cc2)cc1.[Br-],,CC#N,,,,val
US05244863,CCOC(=O)N=C1SC(CBr)CN1c1cccc(C(F)(F)F)c1>>CCOC(=O)N=c1sc(C)cn1-c1cccc(C(F)(F)F)c1,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20090069305A1,CN1CCNCC1.Clc1ccnc(-c2ccsc2)c1>>CN1CCN(c2ccnc(-c3ccsc3)c2)CC1,Cl,O,,CC(C)O,,val
US20100160324A1,O=C(Nc1cn(C2CCCCO2)nc1CO)c1c(Cl)cccc1Cl>>O=Cc1nn(C2CCCCO2)cc1NC(=O)c1c(Cl)cccc1Cl,O=[Mn]=O,CC(C)=O,,,,val
US20080076771A1,CC1(C)OC[C@@H]([C@@H](O)CNc2cc(Nc3ccc(C(=O)Nc4nc(-c5ccc(F)c(C(F)(F)F)c5)ns4)cc3)ncn2)O1>>O=C(Nc1nc(-c2ccc(F)c(C(F)(F)F)c2)ns1)c1ccc(Nc2cc(NC[C@H](O)[C@@H](O)CO)ncn2)cc1,,CO,,Cl,,val
US20150284395A1,CCOC(=O)CC(=O)c1ccc2c(cnn2C)c1.Cn1ccc(-c2cn[nH]c2N)n1>>Cn1ccc(-c2cnn3c(=O)cc(-c4ccc5c(cnn5C)c4)[nH]c23)n1,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20130274269A1,C[C@@H](N)CNC(=O)OC(C)(C)C.ClCCl.O=S(=O)(Cl)c1ccc2cnccc2c1>>C[C@H](CN)NS(=O)(=O)c1ccc2cnccc2c1.Cl.Cl,,ClCCl,,CCN(CC)CC,,val
US20060287286A1,CC1(C)OCc2cc([C@@H](O)CN(CCCCCCCOCCCc3cccc(S(N)(=O)=O)c3)Cc3ccccc3)ccc2O1>>NS(=O)(=O)c1cccc(CCCOCCCCCCCN(Cc2ccccc2)C[C@H](O)c2ccc(O)c(CO)c2)c1,,CCOC(C)=O,,Cl,O=C([O-])O.[Na+],val
US20060205772A1,C=CCOC(=O)Cl.CN(CC1CCCCC1)C(=O)c1ccc(N)cc1>>C=CCOC(=O)Nc1ccc(C(=O)N(C)CC2CCCCC2)cc1,,C1CCOC1,,CN1CCOCC1,,val
US20040063698A1,COC(=O)CBr.O=C(CCCCl)c1ccc(OCc2ccccc2)cc1>>COC(=O)CC1(c2ccc(OCc3ccccc3)cc2)CCCO1,[Zn],C1CCOC1,CCOC(C)=O,II,,val
US20160200695A1,COc1ccc(C(=O)c2ccc(N)cc2)cc1.O=C(O)c1sc2ccccc2c1Cl>>COc1ccc(C(=O)c2ccc(NC(=O)c3sc4ccccc4c3Cl)cc2)cc1,,ClCCl,c1ccncc1,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20100130495A1,Cc1nccn1-c1ccc(Nc2nc3c(c(NC4CCCCC4)n2)CN(C(=O)OC(C)(C)C)CC3)cc1>>Cc1nccn1-c1ccc(Nc2nc3c(c(NC4CCCCC4)n2)CNCC3)cc1,,CO,,Cl,,val
US20130303524A1,CO.O=S1(=O)CCC2CN21>>COC1CCS(=O)(=O)NC1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20070179122A1,COC(=O)c1cc([N+](=O)[O-])ccc1N1CCOCC1=O>>COC(=O)c1cc(N)ccc1N1CCOCC1=O,,CCO,CCOC(C)=O,,,val
US20090176794A1,Nc1ccc2ncccc2c1.O=C(Nn1ccc2ccccc21)Oc1ccccc1>>O=C(Nc1ccc2ncccc2c1)Nn1ccc2ccccc21,,Cc1ccccc1,,,,val
US04865770,CCN.COc1ccc2cc(C(C)C(=O)O)ccc2c1>>CCN.COc1ccc2cc(C(C)C(=O)O)ccc2c1,,CC(C)=O,,,,val
US06184225B2,COCCOc1ccc2c(=O)[nH]cnc2c1.O=S(Cl)Cl>>COCCOc1ccc2c(Cl)ncnc2c1.Cl,,CN(C)C=O,,,,val
US20050107339A1,CCOc1cc(C(O)c2ccc(N(C)C)cc2)ccc1OC>>CCOc1cc(C(=O)c2ccc(N(C)C)cc2)ccc1OC,O=[Mn]=O,ClCCl,,,,val
US20050014685A1,C1CC2CNCCN2C1.CCOC(=O)c1ccc(F)cc1>>CCOC(=O)c1ccc(N2CCN3CCCC3C2)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US05556886,O=Cc1ccc(C(F)(F)F)cc1>>OCc1ccc(C(F)(F)F)cc1,,O,,CO,[BH4-].[Na+],val
US05112385,CN(C)C(=O)NOc1cc(Cl)cc(Cl)c1.O=C(O)C(Cl)(Cl)Cl>>CN(C)C(=O)NOc1cc(Cl)cc(Cl)c1.O=C(O)C(Cl)(Cl)Cl,,CCOCC,,,,val
US20040110804A1,CO.CON(Cc1ccc(F)c(C#N)c1)C(=O)C=C1OC(C)(C)OC1=O>>COC(=O)C(O)=CC(=O)N(Cc1ccc(F)c(C#N)c1)OC,,CO,,,,val
US05202344,CCCCCN1CC(C(=O)OCC)C(N)C1=O.O=C=Nc1ccc(Cl)cc1>>CCCCCN1C[C@@H](C(=O)OCC)[C@@H](NC(=O)Nc2ccc(Cl)cc2)C1=O,,ClCCl,,,,val
US20020019371A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)Cc1cccc(NC)c1>>CCOC(=O)Cc1cccc(N(C)C(=O)OC(C)(C)C)c1,,C1CCOC1,,,,val
US20110003787A1,CNS(=O)(=O)c1ccc(F)c(F)c1.COC[C@H](C)Oc1cc(O)cc(-c2ccc(-c3nccs3)n2C(=O)OC(C)(C)C)c1>>CNS(=O)(=O)c1ccc(Oc2cc(O[C@@H](C)COC)cc(-c3ccc(-c4nccs4)[nH]3)c2)c(F)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04386073,CCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCSC)C(N)=O.Cl>>CCC[C@H](N)C(=O)N[C@@H](CCSC)C(N)=O.Cl,,CCOC(C)=O,CCOCC,,,val
US20150152108A1,COc1cc(Cl)nc(Cl)c1.O=[N+]([O-])O>>COc1cc(Cl)nc(Cl)c1[N+](=O)[O-],,O=S(=O)(O)O,,,,val
US20050234033A1,COC(=O)c1cnc(Br)s1.OCCN1CCNCC1>>COC(=O)c1cnc(N2CCN(CCO)CC2)s1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080176848A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(Br)cc2)c1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>Cn1cc(-c2ccc(S(=O)(=O)n3ccc(/C=C/C(=O)Nc4ccccc4NC(=O)OC(C)(C)C)c3)cc2)cn1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20070037846A1,CCCOc1ccc(C=O)c(OCCN(C)C)c1C.Cl>>CCCOc1ccc(C=O)c(OCCN(C)C)c1C.Cl,,C1COCCO1,,,,val
US04281008,CCCCc1c(OCC2CO2)ccc(C(C)=O)c1O.CCCc1c(O)ccc2c(=O)cc(CCC(=O)OCC)oc12>>CCCCc1c(OCC(O)COc2ccc3c(=O)cc(CCC(=O)OCC)oc3c2CCC)ccc(C(C)=O)c1O,,CCO,,[Na+].[OH-],,val
US20090247571A1,CCC(N)CC.O=[N+]([O-])c1ccc(Cl)nc1Cl>>CCC(CC)Nc1nc(Cl)ccc1[N+](=O)[O-],,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05321135,COC(=O)/C(=C/c1ccc2c(c1)OCO2)Cc1cc(OC)c(OC)c(OC)c1>>COC(=O)C1=Cc2cc3c(cc2-c2c(cc(OC)c(OC)c2OC)C1)OCO3,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,,val
US20100063054A1,COC(=O)c1cn2nc(C(F)(F)c3nnc4ccc(Br)cn34)ccc2n1>>O=C(O)c1cn2nc(C(F)(F)c3nnc4ccc(Br)cn34)ccc2n1,,CO,O,[Li+].[OH-],,val
US20110178070A1,CC1(C)OB(c2cnc(Cl)c(N)c2)OC1(C)C.O=S(=O)(Cl)C1CC1>>O=S(=O)(Nc1cc(B(O)O)cnc1Cl)C1CC1,,c1ccncc1,,,,val
US20160264582A1,CC(C)(C)OC(=O)N1C[C@@H]2CN(Cc3ccccc3)C[C@@H]2C1=O>>O=C1NC[C@@H]2CN(Cc3ccccc3)C[C@H]12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020193596A1,COC(=O)[C@H](CCSC)NC(=O)c1ccc(N)cc1-c1ccccc1C.O=C(Cl)c1cccnc1>>COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC(=O)c2cccnc2)cc1-c1ccccc1C,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US20110301155A1,COCC(O)Cn1ccc([N+](=O)[O-])n1>>COCC(O)Cn1ccc(N)n1,[Pd],CCOC(C)=O,,,,val
US20130261106A1,COC1=C(c2ccc([N+](=O)[O-])c(OC(C)C)c2)CCN(C)C1>>COC1=C(c2ccc(N)c(OC(C)C)c2)CCN(C)C1,[Zn],CC(=O)O,,,,val
US05733922,CC(=O)N1C(=S)NC(=O)C1(C)C.CN(C)c1ccccc1CCl>>CC(=O)N1C(SCc2ccccc2N(C)C)=NC(=O)C1(C)C,,O,,Cl,[Na+].[OH-],val
US06184225B2,COC(=O)Oc1cc(Nc2ncnc3cc(N)c(OC)cc23)c(F)cc1C.COCC(=O)Cl>>COCC(=O)Nc1cc2ncnc(Nc3cc(OC(=O)OC)c(C)cc3F)c2cc1OC,,ClCCl,c1ccncc1,Cl,,val
US20060276655A1,BrCC1CC1.N#CC1CCC(SCC2CC2)CC1>>N#CC1(CC2CC2)CCC(SCC2CC2)CC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20090181948A1,CC(C)I.C[C@@H]1CCCN1CCN1CCN(C2CCNCC2)C1=C(C#N)C#N>>CC(C)N1CCC(N2CCN(CCN3CCC[C@H]3C)C2=C(C#N)C#N)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US03996043,Nc1ccccc1.O=C1OC(=O)[C@H]2CC=CC[C@@H]12>>O=C(O)c1ccccc1C(=O)Nc1ccccc1,,COCCOC,,,,val
US20110152273A1,CC(C)(C)OC(=O)N[C@H]1COCC[C@H]1N.COc1ccc(CN2Cc3c(F)c(Cl)nc(Cl)c3C2=O)c(OC)c1>>COc1ccc(CN2Cc3c(F)c(N[C@@H]4CCOC[C@@H]4NC(=O)OC(C)(C)C)nc(Cl)c3C2=O)c(OC)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US06479531B1,CCOC(=O)c1nc(-c2ccccc2C)n(C)c1CCC12CC3CC(CC(C3)C1)C2>>Cc1ccccc1-c1nc(CO)c(CCC23CC4CC(CC(C4)C2)C3)n1C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120101123A1,CC(C)Oc1ccc(-c2nnc(Br)s2)cc1Cl.CCOC(=O)CCCn1ccc2c(B3OC(C)(C)C(C)(C)O3)ccnc21>>CCOC(=O)CCCn1ccc2c(-c3nnc(-c4ccc(OC(C)C)c(Cl)c4)s3)ccnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20110190365A1,N#CC(C(=O)C(F)(F)F)c1cc(Cl)cc(C(F)(F)F)c1.N#Cc1cc(NN)ccc1F>>N#Cc1cc(-n2nc(C(F)(F)F)c(-c3cc(Cl)cc(C(F)(F)F)c3)c2N)ccc1F,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110152237A1,CCOC(=O)C1CC2(CCC(O)CC2)CN1C(=O)OCc1ccccc1>>CCOC(=O)C1CC2(CCC(=O)CC2)CN1C(=O)OCc1ccccc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20160237090A1,O=C(c1[nH]ccc1-c1ccc(F)cc1)N(CCCl)Cc1ccccc1>>O=C1c2c(-c3ccc(F)cc3)ccn2CCN1Cc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US07105558B2,BrC12CC3CC(CC(C3)C1)C2.C#CCO>>C#CCOC12CC3CC(CC(C3)C1)C2,,CCOC(C)=O,,CCN(CC)CC,,val
US05821387,CC(=Cc1cccc2ccccc12)[N+](=O)[O-]>>CC(=O)Cc1cccc2ccccc12,[Fe],,,Cl,O,val
US20090048258A1,CC(C)(C)O.O=C(O)c1sc(-c2ccccc2)nc1-c1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)Nc1sc(-c2ccccc2)nc1-c1ccccc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20070254896A1,COC(=O)Cc1ccc(OC)cc1.Cc1ccc(N)cc1>>COc1ccc(CC(=O)Nc2ccc(C)cc2)cc1,,CS(C)=O,,[H-].[Na+],,val
US04327102,Cl.ClCc1ccccn1.FC(F)(F)c1cccc(S)c1>>Cl.FC(F)(F)c1cccc(SCc2ccccn2)c1,,CCO,,[Na+].[OH-],,val
US20100298312A1,C1COCCN1.Fc1cc(Br)cc(F)c1F>>Fc1cc(Br)cc(N2CCOCC2)c1F,,O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20070293515A1,Clc1ncnc2c1cnn2C1CCCCO1.N[C@H]1CC[C@@H](c2nc(Cc3ccccc3)cs2)C1>>c1ccc(Cc2csc([C@@H]3CC[C@H](Nc4ncnc5[nH]ncc45)C3)n2)cc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US07351719B2,CCN(CCOc1ccc(NC(=O)COc2ccc(C(F)(F)F)cc2Cl)cc1Cl)C1CCN(C(=O)OC(C)(C)C)CC1>>CCN(CCOc1ccc(NC(=O)COc2ccc(C(F)(F)F)cc2Cl)cc1Cl)C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05827881,CCCCBr.OCCC1CCCCN1>>CCCCN1CCCCC1CCO,,CCO,,[Na+].[OH-],,val
US20120157432A1,BrCc1cnn(-c2ccccc2)n1.CC(C)(C)OC(=O)N1CCNCC1>>c1ccc(-n2ncc(CN3CCNCC3)n2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20090137609A1,C#Cc1ccc(C(CC)(CC)c2ccc(O)c(C)c2)cc1C.CCC(=O)CC>>CCC(O)(C#Cc1ccc(C(CC)(CC)c2ccc(O)c(C)c2)cc1C)CC,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20090036420A1,COc1cccc(NC(=O)c2cccc(S(=O)(=O)N3CCN(C(=O)OC(C)(C)C)CC3)c2)c1>>COc1cccc(NC(=O)c2cccc(S(=O)(=O)N3CCNCC3)c2)c1,,CCO,Cl,,,val
US20020064794A1,CC(=O)OC(C)=O.COS(=O)(=O)c1ccc(C)cc1.COc1cccc2cc3oc(C)nc3nc12.COc1cccc2ccc(N)nc12>>COc1cccc2c1N(C)C1=[NH+]C(C)OC1=C2.COc1cccc2cc(O)c(N)nc12.Cc1ccc(S(=O)(=O)[O-])cc1,,c1ccncc1,,,,val
US20120108583A1,COC(=O)c1cc(N)c(N)cc1O.S=C=Nc1c(Cl)cccc1Cl>>COC(=O)c1cc2nc(Nc3c(Cl)cccc3Cl)[nH]c2cc1O,,CC#N,,,,val
US20130172314A1,N.O=[N+]([O-])c1cccc(-n2cc(I)c3c(Cl)ncnc32)c1>>Nc1ncnc2c1c(I)cn2-c1cccc([N+](=O)[O-])c1,,C1COCCO1,,O,,val
US20020077271A1,CC(=O)c1cc(Nc2cc(C)nc(N)n2)cc(C(C)=O)c1.CI>>CC(=O)c1cc(Nc2cc(C)[n+](C)c(N)n2)cc(C(C)=O)c1.[I-],,C1CCOC1,CC#N,,,val
US20050124692A1,Cc1cc2c(c3c1CCC3)OC(CNC(=O)OCc1ccccc1)C2>>NCC1Cc2ccc3c(c2O1)CCC3,[Pd],,,,,val
US20090012075A1,COc1ccccc1C(=O)NNC(=O)C(F)(F)c1ccc(C(=O)Nc2nn(-c3ccccc3)cc2NC(=O)OC(C)(C)C)cc1>>COc1ccccc1-c1nnc(C(F)(F)c2ccc(C(=O)Nc3nn(-c4ccccc4)cc3NC(=O)OC(C)(C)C)cc2)o1,,C1CCOC1,,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US20140296272A1,CCCC(C(=O)OC)c1c(C)nc2sc3c(c2c1C(C)(C)C)CCC3>>CCCC(C(=O)O)c1c(C)nc2sc3c(c2c1C(C)(C)C)CCC3,,CCO,,Cl,[Na+].[OH-],val
US20080027068A1,CC(=O)c1nn(C)c(-c2cc(C)cc(C)c2)c1O.NNC(=S)Nc1ccc(C(=O)O)cc1>>CC(=NNC(=S)Nc1ccc(C(=O)O)cc1)c1nn(C)c(-c2cc(C)cc(C)c2)c1O,Cl,O,,CN(C)C=O,,val
US20050065210A1,COC(=O)[C@@H]1CC[C@@H](CNS(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1>>O=C(O)[C@@H]1CC[C@@H](CNS(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1,,CO,O,Cl,[K+].[OH-],val
US20140107157A1,CCNC1(C(N)=O)CCNCC1.Cc1c(C(=O)O)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1>>CCNC1(C(N)=O)CCN(C(=O)c2nn(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)c2C)CC1,,C1CCOC1,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20070244087A1,CO[C@@H](C(=O)NC1CSCCN(Cc2cc(Cl)nc(Cl)c2)C1=O)[C@@H]1OC(C)(C)O[C@H](/C=C/C(C)(C)C)[C@@H]1O>>CO[C@@H](C(=O)NC1CSCCN(Cc2cc(Cl)nc(Cl)c2)C1=O)[C@H](O)[C@@H](O)[C@H](O)/C=C/C(C)(C)C,,C1CCOC1,,Cl,[Na+].[OH-],val
US20060189613A1,COc1cc(Cl)nnc1N.O=S(=O)(Cl)c1cccc(Cl)c1Cl>>COc1cc(Cl)nnc1NS(=O)(=O)c1cccc(Cl)c1Cl,,COCCOC,,CC(=O)O,[H-].[Na+],val
US20080305956A1,BrCC1CC1.COC(=O)c1ccc(Cl)c(S)c1C>>COC(=O)c1ccc(Cl)c(SCC2CC2)c1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130281438A1,CCOC(=O)Cc1c(Cl)nc(Cl)nc1Cl.COc1ccc(CN)cc1>>CCOC(=O)Cc1c(Cl)nc(Cl)nc1NCc1ccc(OC)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05574178,CC(C)(C)c1c(OCc2ccccc2)ccc2oc(C=O)cc12>>CC(C)(C)c1c(O)ccc2c1CC(CO)O2,[Pd],CC(=O)O,CCOC(C)=O,,,val
US04612317,ClCc1ccc(Cl)cc1.OC[C@H]1Cc2c([nH]c3ccccc23)CN1.S=C=S>>OC[C@H]1Cc2c([nH]c3ccccc23)CN1C(=S)SCc1ccc(Cl)cc1,,CCO,CO,[K+].[OH-],,val
US20150197530A1,CCOC(=O)Cc1cc(C(=O)c2ccco2)sc1-c1ccc(Cl)cc1.O=C1CCC(=O)N1Cl>>CCOC(=O)Cc1cc(C(=O)c2ccc(Cl)o2)sc1-c1ccc(Cl)cc1,,CC#N,,,,val
US20140296200A1,CN(C1CC1)C1CN(C(=O)OC(C)(C)C)C1>>CN(C1CC1)C1CNC1,,Cl,ClCCl,C1COCCO1,,val
US20090291971A1,COCCOC.Cn1ccc(On2nnc3cccnc32)nc1=O.O=C(O)Cc1ccc(B(O)O)cc1>>COC(=O)c1ccc(Oc2ccn(C)c(=O)n2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080188528A1,Cc1ccc(F)nc1.O=Cc1ccccc1>>Cc1cnc(F)c(C(O)c2ccccc2)c1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20120245345A1,COc1ccc2ncc(Cl)c(C=C(C=O)[C@@H]3CC[C@@H](NC(=O)OC(C)(C)C)CC3)c2n1.NCc1ccccc1>>COc1ccc2ncc(Cl)c(C=C(CNCc3ccccc3)[C@@H]3CC[C@@H](NC(=O)OC(C)(C)C)CC3)c2n1,,CCO,CCOC(C)=O,CC(=O)O,[BH3-]C#N.[Na+],val
US20050038071A1,CC(C)CC=C[C@H]1CCC[C@H](C)N1C(=O)OC(C)(C)C>>CC(C)CCC[C@H]1CCC[C@H](C)N1C(=O)OC(C)(C)C,[Pd],CCO,,,,val
US20150065550A1,Cc1ccccc1CC(CC=O)OCc1ccccc1>>Cc1ccccc1CC(CCO)OCc1ccccc1,,CO,,[BH4-].[Na+],,val
US04353908,Cc1cc(O)nc(C(Cl)(Cl)Cl)n1.O=C(Cl)Oc1ccccc1>>Cc1cc(OC(=O)Oc2ccccc2)nc(C(Cl)(Cl)Cl)n1,,CCOCC,,CCN(CC)CC,,val
US05750531,CC1c2ccccc2CCN1c1nc(Cl)nc2c1CCCC2.CNc1ccccc1>>CC1c2ccccc2CCN1c1nc(N(C)c2ccccc2)nc2c1CCCC2.Cl,,CN(C)C=O,,,,val
US20020045654A1,BrC(Br)(Br)Br.CSc1ccc(CO)cc1F>>CSc1ccc(CBr)cc1F,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100249123A1,COc1ccc(C(=O)Nc2ccc(C3(C#N)CCCC3)cc2)cc1OC>>COc1ccc(C(=O)Nc2ccc(C3(CN)CCCC3)cc2)cc1OC,[Pd],CCO,,Cl,,val
US20100029611A1,COC(=O)CBr.OCc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1>>COC(=O)COCc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1,,CN(C)C=O,,[H-].[Na+],,val
US20150307451A1,COc1ccc(CN2Cc3cc(C)c(Cc4ccc(-n5cccn5)cc4)cc3C2=O)c(OC)c1>>Cc1cc2c(cc1Cc1ccc(-n3cccn3)cc1)C(=O)NC2,,O=C(O)C(F)(F)F,,COc1ccccc1,,val
US20080318946A1,COC(=O)c1c(Cl)ccc2c(Nc3cccc(C(F)(F)F)c3)noc12>>O=C(O)c1c(Cl)ccc2c(Nc3cccc(C(F)(F)F)c3)noc12,,C1COCCO1,,[Li+].[OH-],,val
US20070066820A1,c1ccc(COc2ccc(Oc3cccnc3)cc2)cc1>>Oc1ccc(Oc2cccnc2)cc1,[Pd],CCO,,C1CCOC1,,val
US20120225866A1,CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(O)ccc21.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OS(=O)(=O)C(F)(F)F)ccc21,,O,,CCN(CC)CC,ClCCl,val
US20050165054A1,C=CC(C)=O.C[N+](=O)[O-]>>CC(=O)CCC[N+](=O)[O-],,C1CCOC1,,[F-].[K+],,val
US20050054633A1,BrCC1CC1.CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CNc2ccccc21.O=C=O>>CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CN(C(=O)OCC2CC2)c2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130109678A1,CCCCN1CCNCC1.Nc1cc(Cl)ccc1[N+](=O)[O-]>>CCCCN1CCN(c2ccc([N+](=O)[O-])c(N)c2)CC1,,CC(=O)N(C)C,,O,O=C([O-])[O-].[K+].[K+],val
US05576343,COC(=O)C(=O)c1ccc(O)cc1.O[C@H]1CCOC1>>COC(=O)C(=O)c1ccc(O[C@@H]2CCOC2)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05521170,CCOC(=O)CN1C(=O)CCNc2ccccc21>>CCOC(=O)CN1CCCNc2ccccc21,,C1CCOC1,,,,val
US05128364,NO.O=C1CCn2c1cc1ccccc12>>ON=C1CCn2c1cc1ccccc12,,CCO,O,Cl,c1ccncc1,val
US06355655B1,C1CCC2=NCCCN2CC1.CC(C)S(=O)(=O)Cl.ClCCl>>CC(CNS(=O)(=O)C(C)C)C1CCCN1C,,O,,,,val
US20030232850A1,CI.O=C(OCc1ccccc1)N1CCc2c([nH]c3ccccc23)C1>>Cn1c2c(c3ccccc31)CCN(C(=O)OCc1ccccc1)C2,,CN(C)C=O,,O,[H-].[Na+],val
US20070225267A1,CC(=O)OC(C)=O.CCCOc1cc(F)cc(CC(N)C(O)C2COC(OCC(C)(CF)CF)C(C)N2C(=O)OC(C)(C)C)c1>>CCCOc1cc(F)cc(CC(NC(C)=O)C(O)C2COC(OCC(C)(CF)CF)C(C)N2C(=O)OC(C)(C)C)c1,,ClCCl,,CCN(CC)CC,,val
US20030224283A1,C=C(C)C(=O)Cl.OCc1ccc2cc(O)ccc2c1>>C=C(C)C(=O)Oc1ccc2cc(CO)ccc2c1,,ClCCl,,CCN(CC)CC,,val
US06511974B1,CNN.O=CC(=CO)c1ccc(C(=O)O)cn1>>Cn1cc(-c2ccc(C(=O)O)cn2)cn1,,CCO,,,,val
US20050245515A1,COC(=O)c1cccc(-c2nc(CN3c4ccc(C(O)(C(F)(F)F)C(F)(F)F)cc4CC3C)c(C)o2)c1>>Cc1oc(-c2cccc(CO)c2)nc1CN1c2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2CC1C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04739066,CCOC(=O)C(=O)OCC.CCOC(=O)CCCCCC1CCN(C(=O)OC(=O)c2ccccc2)CC1>>CCOC(=O)C(=O)CCCCCC1CCN(C(=O)OCc2ccccc2)CC1,,CCO,,[Na],,val
US20040248918A1,CN1CCCNCC1.Cc1ccc(NC(=O)c2ccc(CCl)cc2)cc1Nc1nccc(-c2cccnc2)n1>>Cc1ccc(NC(=O)c2ccc(CN3CCCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,,C1CCOC1,,c1ccncc1,,val
US04563455,ClCc1nc2ccccc2n1-c1ccccc1.c1c[nH]cn1>>c1ccc(-n2c(Cn3ccnc3)nc3ccccc32)cc1,,CCO,O,,,val
US20130345212A1,CCOC(=O)c1c(O)c2cc(I)c(Cl)cc2[nH]c1=O>>O=c1cc(O)c2cc(I)c(Cl)cc2[nH]1,,C1COCCO1,,Cl,,val
US20140256775A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)CCCCCC(=O)O.Nc1cccc(O)c1>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)CCCCCC(=O)Nc1cccc(O)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120071535A1,C1=COCCC1.Fc1cc(Br)cc2cn[nH]c12>>Fc1cc(Br)cc2cnn(C3CCCCO3)c12,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20140309220A1,CC(C)(C)Sc1ccc(C(=O)O)cc1.O=S([O-])OO>>CC(C)(C)S(=O)c1ccc(C(=O)O)cc1,,CO,,O,,val
US05571816,CCCCN(C(=O)C(C#N)=CNC(=N)N1CCNC1=O)c1cccc(C(F)(F)F)c1.N#CCC(=O)O>>C=CC1CN(c2ncc(C(=O)N(C)c3cccc(C(F)(F)F)c3)c(N)n2)C(=O)N1,,CC(=O)O,,,,val
US20080070937A1,COc1ccc(S(=O)(=O)Cl)cc1OC.Cn1nc(-c2ccccc2)cc1N>>COc1ccc(S(=O)(=O)Nc2cc(-c3ccccc3)nn2C)cc1OC,,c1ccncc1,,,,val
US20080058356A1,BrC1CCC1.COC(=O)Cc1ccc(O)c(OC)c1>>COC(=O)Cc1ccc(OC2CCC2)c(OC)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20020006937A1,BrCc1ccccc1.O=C(NCc1ccc(Cl)cc1)c1cnc2sc(CN3CCOCC3)cc2c1O>>O=C(NCc1ccc(Cl)cc1)c1cn(Cc2ccccc2)c2sc(CN3CCOCC3)cc2c1=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060035936A1,C=CCN(CC(OC)OC)c1cnc(Cl)c(Cl)c1>>C=CCN(CC=O)c1cnc(Cl)c(Cl)c1,,C1CCOC1,O,Cl,ClCCl,val
US20120258946A1,COC(=O)c1ccc(N)cc1Cl.O=C(Cl)Oc1ccccc1>>COC(=O)c1ccc(NC(=O)Oc2ccccc2)cc1Cl,,CC#N,,c1ccncc1,,val
US20070232585A1,CCOC(=O)CC1CCCc2c1cnn2-c1ccccc1>>O=C(O)CC1CCCc2c1cnn2-c1ccccc1,,CO,O,[Li]O,,val
US20080076800A1,COc1cccc(-c2ccc(C#N)c(F)c2)c1OC.NC1CCC(O)CC1>>COc1cccc(-c2ccc(C#N)c(NC3CCC(O)CC3)c2)c1OC,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20140243349A1,COc1cc(Br)cc(OC)c1OC>>Oc1cc(Br)cc(O)c1O,,ClCCl,,BrB(Br)Br,,val
US20130274260A1,NC1CCCC1.O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(CCl)cc1>>O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(CNC2CCCC2)cc1,,C1CCOC1,,[I-].[Na+],,val
US20120172333A1,CCOC(=O)c1c(NC(=O)CC#N)cc(Cl)n1-c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.NS(=O)(=O)c1ccc(Br)s1>>N#Cc1c(O)c2c(cc(Cl)n2-c2ccc(-c3ccc(S(N)(=O)=O)s3)cc2)[nH]c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,O,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US05068340,CCCCCCCCCCCCCCBr.Cc1cc(O)no1>>CCCCCCCCCCCCCCCc1cc(O)no1,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US20100041920A1,C#CCN[C@@H]1CCc2ccccc21.O=P(O)(O)O>>C#CCN[C@@H]1CCc2ccccc21.O=P([O-])([O-])[O-],,CC(C)O,,,,val
US04562192,CCOCCc1c(-c2ccccc2)nc(Cl)n2ncnc12.[N-]=[N+]=[N-]>>CCOCCc1c(-c2ccccc2)n2nnnc2n2ncnc12,,CS(C)=O,,O,,val
US20080096877A1,CCN=C=NCCCN(C)C.COCCOc1cc(N(C)S(=O)(=O)c2cccs2)c2[nH]c(C(=O)O)cc2c1>>COCCOc1cc(N(C)S(=O)(=O)c2cccs2)c2[nH]c(C(N)=O)cc2c1,,O,,CN(C)C=O,Cl,val
US20100240678A1,CC(=O)c1cc(O)cc(O)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CC(=O)c1cc(OS(=O)(=O)C(F)(F)F)cc(OS(=O)(=O)C(F)(F)F)c1.CCOCC,,ClCCl,,,,val
US20120129840A1,CCCC(C(=O)OC)c1c(Cl)nc(N2CCCCC2)nc1CC.Cc1ccc(B(O)O)cc1>>CCCC(C(=O)OC)c1c(CC)nc(N2CCCCC2)nc1-c1ccc(C)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,CCN(C(C)C)C(C)C,,val
US20020120148A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Oc1ccc2c(c1)CCCC(NCc1ccccc1)C2>>CC(C)(C)OC(=O)N(Cc1ccccc1)C1CCCc2cc(O)ccc2C1,,C1CCOC1,,,,val
US06723722B1,O=C1CN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CCN1NC1CCN(c2ccncc2)CC1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>O=S(=O)(c1ccc2cc(Cl)ccc2c1)N1CCN(NC2CCN(c3ccncc3)CC2)C(=S)C1,,c1ccncc1,,,,val
US20100240610A1,CCOC(=O)CNC(=O)c1c(O)c2cc(B3OC(C)(C)C(C)(C)O3)ccc2n(C)c1=O.Clc1cc(Cl)ncn1>>CCOC(=O)CNC(=O)c1c(O)c2cc(-c3cc(Cl)ncn3)ccc2n(C)c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20070299069A1,C[C@@H](OC(=O)Nc1ccc(-c2c(C#N)c3ccc(O)cc3n2C2CCC2)cc1)C1CC1.Clc1ncccn1>>C[C@@H](OC(=O)Nc1ccc(-c2c(C#N)c3ccc(Oc4ncccn4)cc3n2C2CCC2)cc1)C1CC1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05877191,C=[N+]=[N-].COc1ccc(C=C(C)[N+](=O)[O-])cc1Br>>COc1ccc(C2CN=NC2(C)[N+](=O)[O-])cc1Br,,CCOC(C)=O,CCOCC,CC(=O)O,,val
US20090018122A1,CCOC(OCC)OC(C)=O.Nc1cnc2cc(OCc3ccccc3)ccc2c1NCCOc1ccccc1>>c1ccc(COc2ccc3c(c2)ncc2ncn(CCOc4ccccc4)c23)cc1,,Cc1ccccc1,,,,val
US20100113542A1,CO.O=C(O)c1cc(Br)c(O)cc1O>>COC(=O)c1cc(Br)c(O)cc1O,,CO,O,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US04241071,BrCCCOc1ccccc1.c1ccc(Cc2ccccc2C2CCNCC2)cc1>>c1ccc(Cc2ccccc2C2CCN(CCCOc3ccccc3)CC2)cc1,,CCCCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060030613A1,CC(C)(C)c1ccc(O)cc1.O=C1CCC(=O)N1Cl>>CC(C)(C)c1ccc(O)c(Cl)c1,,CC#N,,,,val
US20090270460A1,CC(C)c1cnn(-c2c(Cl)cccc2Cl)c1CBr.Cc1cc(O)ccc1Br>>Cc1cc(OCc2c(C(C)C)cnn2-c2c(Cl)cccc2Cl)ccc1Br,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110237849A1,CCCC1CCC(CCc2ccc(C3CCC(=COC)CC3)cc2)CC1>>CCCC1CCC(CCc2ccc([C@@H]3CC[C@@H](C=O)CC3)cc2)CC1,,C1CCOC1,,Cl,,val
US20030013886A1,Fc1ccccn1.Nc1ccc(C(F)(F)F)cc1[N+](=O)[O-]>>O=[N+]([O-])c1cc(C(F)(F)F)ccc1Nc1ccccn1,,CC(=O)N(C)C,,[H-].[Na+],,val
US20110275611A1,CNc1nc(-c2cc(F)c(C#N)c(F)c2)cc(N2CCC[C@H]2C(F)(F)F)n1.CO>>CNc1nc(-c2cc(F)c(C#N)c(OC)c2)cc(N2CCC[C@H]2C(F)(F)F)n1,,CO,,[Na],C[O-].[Na+],val
US05681840,CC12COC(c3cncc(C4(O)CCN(CC56CC(c7ccccc75)c5ccccc56)CC4)c3)(OC1)OC2.CO>>COC(=O)c1cncc(C2(O)CCN(CC34CC(c5ccccc53)c3ccccc34)CC2)c1,,CO,,O=S(=O)(O)O,[Na+].[OH-],val
US20110263626A1,NCc1ccc(Oc2ccc(Br)cc2Cl)cc1.O=C(NC1(C(=O)O)CC1)c1cncnc1>>O=C(NC1(C(=O)NCc2ccc(Oc3ccc(Br)cc3Cl)cc2)CC1)c1cncnc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20050187236A1,C1CSCCN1.CC(C)(C)OC(=O)OC(=O)OC(=O)[O-]>>CC(C)(C)OC(=O)N1CCSCC1,,C1CCOC1,,CCN(CC)CC,,val
US20090286768A1,Brc1ccc(I)cc1.OC1CCCCC1>>Brc1ccc(OC2CCCCC2)cc1,[Cu]I,Cc1ccccc1,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US20060189650A1,CSc1ccc(S)cc1.Cc1ccc(S(=O)(=O)OCCC2CCN(C(=O)OC(C)(C)C)CC2)cc1>>CSc1ccc(SCCC2CCN(C(=O)OC(C)(C)C)CC2)cc1,,CN(C)C=O,ClCCl,[H-].[Na+],,val
US20120071482A1,O=C1c2ccccc2C(=O)N1CCc1c(Cl)ncnc1N[C@H]1CCc2ccccc21>>NCCc1c(Cl)ncnc1N[C@H]1CCc2ccccc21,,CCO,,NN,O,val
US20090131461A1,BrBr.COc1cc2c(=O)cc[nH]c2cc1OCc1ccccc1>>COc1cc2c(=O)c(Br)c[nH]c2cc1OCc1ccccc1,,CC(=O)O,,,,val
US20050250797A1,CN1CCNCC1=O.COCCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCCCl)c(OC)cc23)c2c1OCO2>>COCCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCCN4CCN(C)C(=O)C4)c(OC)cc23)c2c1OCO2,,COCCO,,,,val
US05422360,CCOC(=O)CN1C(=O)CSC1=NN=C(C)C>>CCOC(=O)CN1C(=O)CSC1=NN,,ClC(Cl)Cl,,Cl,O=C([O-])O.[Na+],val
US20110275611A1,CS(=O)(=O)Cl.C[C@@H]1CO[C@H](CO)CN1Cc1ccccc1>>C[C@@H]1CO[C@H](COS(C)(=O)=O)CN1Cc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20040049008A1,C#CCCC(=O)O.CCOC(=O)CON>>C#CCCC(=O)NOCC(=O)OCC,,CCOC(C)=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20020173664A1,C[C@@H]1NC(=O)OC1=O.Cc1ccc(C(=O)Cl)cc1>>Cc1ccc(C(=O)N2C(=O)OC(=O)[C@@H]2C)cc1,CN(C)c1ccncc1,CCOC(C)=O,,,,val
US20030229094A1,NC1CCCCC1.O=C(Cl)CBr>>O=C(CBr)NC1CCCCC1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20110015175A1,BrBr.O=C1CCCCC1=O>>O=C1CCCC(Br)C1=O,,ClC(Cl)(Cl)Cl,,,,val
US20090029994A1,O=S(=O)(Oc1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ncc(N2CCOCC2)cn1)C(F)(F)F.OB(O)c1ccccc1>>FC(F)(F)c1cc(CN(Cc2cc(C(F)(F)F)ccc2-c2ccccc2)c2ncc(N3CCOCC3)cn2)cc(C(F)(F)F)c1,,C1COCCO1,CCOC(C)=O,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20100197924A1,CC(C)(C)OC(=O)c1cc(CN)cc(C(F)(F)F)c1>>NCc1cc(C(=O)O)cc(C(F)(F)F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070093521A1,CCOc1cc(C=O)cc(OCC)c1F.O=[N+]([O-])c1cccc2oc(NC3CCNCC3)nc12>>CCOc1cc(CN2CCC(Nc3nc4c([N+](=O)[O-])cccc4o3)CC2)cc(OCC)c1F,,CC(=O)O,CCO,CCN(C(C)C)C(C)C,[BH3-]C#N.[Na+],val
US20120237475A1,FC1(F)CCNCC1.O=C1C=C(O)C(c2ccc(N3CCOCC3)cc2)N1c1ccc2[nH]cnc2c1>>O=C1C=C(N2CCC(F)(F)CC2)C(c2ccc(N3CCOCC3)cc2)N1c1ccc2[nH]cnc2c1,,CN(C)C=O,Cc1ccccc1,Cl,O=C([O-])[O-].[K+].[K+],val
US04753950,BrCc1ccccc1.Nc1c2c(nc3sccc13)CCCC2=O>>O=C1CCCc2nc3sccc3c(NCc3ccccc3)c21,,CS(C)=O,,O,[K+].[OH-],val
US20120077799A1,Nc1ncccc1-c1ccc(Oc2cccc(Cl)c2)cc1.O=S(=O)(Cl)CCCl>>O=S1(=O)CCN2C=CC=C(c3ccc(Oc4cccc(Cl)c4)cc3)C2=N1,,C1CCOC1,,[H-].[Na+],,val
US05412097,CCc1nc2c(C)cc(C)nc2[nH]1.N#Cc1ccccc1-c1ccc(CBr)cc1>>CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C#N)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100055665A1,CCOC(=O)c1nc2c3cccnc3c3nc(CO)ccc3c2nc1C(=O)OCC.ClP(Cl)Cl>>CCOC(=O)c1nc2c3cccnc3c3nc(CCl)ccc3c2nc1C(=O)OCC,,ClC(Cl)Cl,,,,val
US20150023913A1,C[C@@]1(CO)CC(F)(F)CO1.O=[Cr](=O)=O>>C[C@@]1(C(=O)O)CC(F)(F)CO1,,CC(C)=O,CCOC(C)=O,O=S(=O)(O)O,,val
US20040266753A1,COc1cc2c(c3c1c(=O)c1c4ccccc4ccc1n3C)C=CC(C)(C)O2.O=[Mn](=O)(=O)[O-]>>COc1cc2c(c3c1c(=O)c1c4ccccc4ccc1n3C)C(=O)C(O)C(C)(C)O2,,CC(C)=O,,O,,val
US20120295883A1,COc1ccc(Cn2nc(Oc3ccccc3)c3c(NC4CCOCC4)nccc32)cc1>>c1ccc(Oc2n[nH]c3ccnc(NC4CCOCC4)c23)cc1,,ClCCl,,O=S(=O)(O)C(F)(F)F,,val
US20130029949A1,C#Cc1ccccn1.CC(=O)c1cccnc1Br>>CC(=O)c1cccnc1C#Cc1ccccn1,,CN(C)C=O,ClCCl,CCN(CC)CC,,val
US20120245210A1,CN(C)C=O.N#Cc1ccc(-c2cscc2Br)cc1>>N#Cc1ccc(-c2csc(C=O)c2Br)cc1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20090298823A1,CCOC(=O)CC1CCNCC1.Clc1nc(Cl)c2cc[nH]c2n1>>CCOC(=O)CC1CCN(c2nc(Cl)nc3[nH]ccc23)CC1,,C1COCCO1,CCOC(C)=O,CCN(C(C)C)C(C)C,O,val
US20130296375A1,C[C@@H]1OC(=O)[C@@H](N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)COC[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1>>C[C@@H]1OC(=O)[C@@H](N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)COC[C@H](O)[C@H]1O,[Pd],CCOC(C)=O,,,,val
US20130267510A1,Cc1ccc(B(O)O)c2c1OC(F)(F)O2.OO>>Cc1ccc(O)c2c1OC(F)(F)O2,,C1CCOC1,,[Na+].[OH-],,val
US04602014,CCOC(=O)c1cnc2c(c1Cl)CSC2.NNc1ccc(Cl)cc1>>O=c1c2c[nH]c3c(c-2nn1-c1ccc(Cl)cc1)CSC3,,CCCCO,,,,val
US04485114,C1CCOC1.CSC(C)S(=O)C(C)SC.O=Cc1cccc(Oc2cccc(C(F)(F)F)c2)c1>>O=C(c1cccc(Oc2cccc(C(F)(F)F)c2)c1)C(O)O,,CCCCCC,,[Li]CCCC,,val
US03998829,CC(=O)OCC(I)C(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C.CCNCC>>CCN(CC)CC(=O)OCCC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C,,ClCCl,,,,val
US05536752,CSc1ccc(C(=O)C(C)(C)O)cc1.O=C(Cl)Cc1ccc(F)cc1>>CSc1ccc(C(=O)C(C)(C)OC(=O)Cc2ccc(F)cc2)cc1,,ClCCl,,c1ccncc1,,val
US05530028,CC(C)[Mg]Cl.COc1cccc(C2=NCC(C)(C)O2)c1OC>>COc1cccc(C(=O)O)c1C(C)C,,C1CCOC1,,CCOCC,[Cl-].[NH4+],val
US20070225267A1,CC(=O)OC(C)=O.C[C@H]1[C@H](OCC(F)(F)F)OC[C@H]([C@@H](O)[C@@H](N)Cc2cc(O)cc(F)c2)N1C(=O)OC(C)(C)C>>CC(=O)N[C@@H](Cc1cc(O)cc(F)c1)[C@H](O)[C@H]1CO[C@@H](OCC(F)(F)F)[C@H](C)N1C(=O)OC(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110195977A1,CC(=O)OC(C)=O.COc1ccc(/C=C/C(=O)O)cc1O>>COc1ccc(/C=C/C(=O)O)cc1OC(C)=O,,C1CCOC1,,[H-].[Na+],,val
US20120178751A1,CC(C)(C)C(=O)Nc1cc(-c2cn3cc(Cl)ncc3n2)ccc1C(F)(F)F.OB(O)c1ccccc1F>>CC(C)(C)C(=O)Nc1cc(-c2cn3cc(-c4ccccc4F)ncc3n2)ccc1C(F)(F)F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC(C)O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20050136357A1,CCCCO.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O=C(O)c1ccc(-c2ccc(C(=O)O)cc2)cc1>>CCCCOC(=O)c1ccc(-c2ccc(C(=O)OCCCC)cc2)cc1,,ClCCl,O,Cc1ccccc1,,val
US04039543,CN(C)c1cc(C(O)CS(C)(=O)=O)cc(N(C)C)c1N(C)C.N#CCCNc1ccccc1>>CN(C)c1cc(CC(C#N)CNc2ccccc2)cc(N(C)C)c1N(C)C,,CS(C)=O,,C[O-].[Na+],,val
US20090299089A1,COC(=O)/C=C(/C)NC(C)=O>>COC(=O)C[C@@H](C)NC(C)=O,,C1CCOC1,,,,val
US20140187545A1,CO.Cc1c(Cc2cnn3c(Cl)cc(N4CCOCC4)nc23)cccc1C(F)(F)F>>COc1cc(N2CCOCC2)nc2c(Cc3cccc(C(F)(F)F)c3C)cnn12,,CO,,C[O-].[Na+],,val
US06291677B1,CCOC(=O)Cc1ccc(C#Cc2ccc3c(c2)C(C)(C)CCC3N(C)C2CC2)cc1F>>CN(C1CC1)C1CCC(C)(C)c2cc(C#Cc3ccc(CC(=O)O)c(F)c3)ccc21,,O,,CO,[Li+].[OH-],val
US20160122341A1,Cc1cn2cccc(OCc3c(F)cccc3F)c2n1.O=C1CCC(=O)N1Br>>Cc1nc2c(OCc3c(F)cccc3F)cccn2c1Br,,CCO,,CCOC(C)=O,,val
US20150175604A1,CCCC[Sn](CCCC)(CCCC)c1cn(C)cn1.Clc1ccc2c(cc(Br)n2Cc2ccccc2)n1>>Cn1cnc(-c2cc3nc(Cl)ccc3n2Cc2ccccc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US04351843,COC(=O)c1c[nH]c(C(=O)c2ccccc2)c1-c1ccccc1>>O=C(O)c1c[nH]c(C(=O)c2ccccc2)c1-c1ccccc1,,CO,,[Na+].[OH-],,val
US20090036492A1,C[Sn](C)(C)C.O=Cc1c(Br)ccc2cc(Cl)ccc12>>Cc1ccc2cc(Cl)ccc2c1C=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US04021421,CN1C(=O)CN(N)C(c2ccccc2)c2cc(Cl)ccc21.O=Cc1ccccc1>>CN1C(=O)CN(N=Cc2ccccc2)C(c2ccccc2)c2cc(Cl)ccc21,,c1ccccc1,,,,val
US20100029650A1,CC(C)OC(=O)N1CCC(COS(C)(=O)=O)CC1.CS(=O)(=O)c1ccc(-c2cnc(O)cn2)c(F)c1>>CC(C)OC(=O)N1CCC(COc2cnc(-c3ccc(S(C)(=O)=O)cc3F)cn2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060257987A1,CCc1ccc(O)c(-c2ccco2)c1.CN(C)C=O.COC(=O)CCc1ccc(OCC[C@H](C)OS(C)(=O)=O)cc1>>CCc1ccc(O[C@@H](C)CCOc2ccc(CCC(=O)OC)c(C)c2)c(-c2ccco2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060173058A1,COCCOCOc1cc(NCc2ccc(F)cc2)ccc1C#N>>N#Cc1ccc(NCc2ccc(F)cc2)cc1O,,C1CCOC1,,Cl,,val
US20120208839A1,CN.O=C(N[C@@H]1CC[C@@H](C(F)(F)F)CC1)c1cc([N+](=O)[O-])c(Cl)nc1OCCF>>CNc1nc(OCCF)c(C(=O)N[C@@H]2CC[C@@H](C(F)(F)F)CC2)cc1[N+](=O)[O-],,C1CCOC1,,,,val
US20090156836A1,CCCC[Sn](Cl)(CCCC)CCCC.COc1cccc(CO)c1>>CCCC[Sn](CCCC)(CCCC)c1c(CO)cccc1OC,,c1ccccc1,,[Li]CCCC,[Cl-].[NH4+],val
US20150119362A1,CCCN.CCc1cc(Cc2ccc(CC(=O)Cl)cc2)nc(-c2cccc(Cl)c2)n1>>CCCNC(=O)Cc1ccc(Cc2cc(CC)nc(-c3cccc(Cl)c3)n2)cc1,,ClCCl,O,CCN(C(C)C)C(C)C,Cl,val
US20140005164A1,CCOc1ccc2c(c1)n(C[C@@H]1CC[C@@H](C(=O)OC)CC1)c(=O)n2C>>CCOc1ccc2c(c1)n(C[C@@H]1CC[C@@H](C(=O)O)CC1)c(=O)n2C,,C1CCOC1,O,Cl,[Li+].[OH-],val
US04144347,Brc1coc2ccccc12.O=[N+]([O-])O>>O=[N+]([O-])c1oc2ccccc2c1Br,,CO,,O=N[O-].[Na+],,val
US20030232848A1,CC(C)c1ccc(S(=O)(=O)Nc2c(-c3ccc4c(c3)OCO4)c(OCCO)nn2C)nc1.Clc1ncc(Br)cn1>>CC(C)c1ccc(S(=O)(=O)Nc2c(-c3ccc4c(c3)OCO4)c(OCCOc3ncc(Br)cn3)nn2C)nc1,,C1CCOC1,CC(=O)N(C)C,[H-].[Na+],,val
US20080292626A1,CC(C)C(N=[N+]=[N-])c1nc2c(oc3ccccc32)c(=O)n1Cc1ccccc1>>CC(C)C(N)c1nc2c(oc3ccccc32)c(=O)n1Cc1ccccc1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050153959A1,CCc1cc(CC(C#N)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)cc2c(C)n[nH]c12.C[Sn](C)(C)N=[N+]=[N-]>>CCc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nnn[nH]2)cc2c(C)n[nH]c12,,C1CCOC1,,,,val
US20130059834A1,CC(C)(C)OC(=O)N[C@H]1CC[C@@H](N)CC1.Cn1nc(-c2cnc3[nH]cc(C(=O)O)c3n2)c2cc(OC(F)F)ccc21>>Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@@H]4CC[C@H](NC(=O)OC(C)(C)C)CC4)c3n2)c2cc(OC(F)F)ccc21,,C1CCOC1,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US04851413,Brc1cccnc1.O=C1CCCO1>>O=C(CCCO)c1cccnc1,,CCOCC,,CCCCCC,[Li]CCCC,val
US20040209905A1,COc1cc2nccc(Oc3c(Cl)cc(N)cc3Cl)c2cc1OC.O=C=Nc1ccc(F)cc1F>>COc1cc2nccc(Oc3c(Cl)cc(NC(=O)Nc4ccc(F)cc4F)cc3Cl)c2cc1OC,,ClC(Cl)Cl,,,,val
US04912098,CCC(=O)O[C@]1(C(=O)COC(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](OC(=O)C(F)(F)F)C[C@@]21C>>CCC(=O)O[C@]1(C(=O)COC(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C,,CO,,CCN(CC)CC,,val
US20120011765A1,CCCCCCCCC(=O)O.CO>>CCCCCCCCC(=O)OC,O=S(=O)(O)O,,,,,val
US20030060466A1,CC(C)Br.Cc1nc(N2CCN(c3ccc(F)cc3)CC2)c([N+](=O)[O-])c(=O)[nH]1>>Cc1nc(OC(C)C)c([N+](=O)[O-])c(N2CCN(c3ccc(F)cc3)CC2)n1,,CN(C)C=O,,[I-].[K+],,val
US20110046132A1,CCOC(=O)c1cnn(-c2nc3cc(S(=O)(=O)Nc4ccccc4)c(Cl)cc3n2COCCOC)c1>>CCOC(=O)c1cnn(-c2nc3cc(S(=O)(=O)Nc4ccccc4)c(Cl)cc3[nH]2)c1,,C1COCCO1,CCO,Cl,,val
US20070155805A1,CCCCC(CCO)c1sc2cc(F)ccc2c1C.CCOC(=O)COc1ccc(O)cc1C>>CCCCC(CCOc1ccc(OCC(=O)OCC)c(C)c1)c1sc2cc(F)ccc2c1C,,C1CCOC1,O,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20040224997A1,CC(=O)c1ccc(OS(=O)(=O)C(F)(F)F)cc1C.O=[N+]([O-])c1ccc(B(O)O)cc1>>CC(=O)c1ccc(-c2ccc([N+](=O)[O-])cc2)cc1C,,Cc1ccccc1,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20090124609A1,COc1cnc2ccc(C(C)C(=O)OC(C)(C)C)cc2c1.Cl>>COc1cnc2ccc(C(C)C(=O)O)cc2c1.Cl,,CCOC(C)=O,,,,val
US05356863,CC(=O)O.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(N)c(Cl)cc2F)c1=O>>CC(=O)Nc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl,,c1ccccc1,,,,val
US05663297,CC(C)(C)OC[C@H](NC(=O)[C@@H](N)CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C.O=C(CNC(=O)OCc1ccccc1)ON1C(=O)CCC1=O>>CC(C)(C)OC[C@H](NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)CNC(=O)OCc1ccccc1)C(=O)OC(C)(C)C,,CO,,,,val
US20130059833A1,BrC(Br)(Br)Br.OCc1nc(-c2ccccc2)nn1-c1ccccc1>>BrCc1nc(-c2ccccc2)nn1-c1ccccc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100152208A1,CC(C)O.COC(=O)CCc1nc(Cl)c2sc(N3CCC(Oc4cc(F)ccc4Br)CC3)nc2n1>>CC(C)Oc1nc(CCC(=O)O)nc2nc(N3CCC(Oc4cc(F)ccc4Br)CC3)sc12,,CC(C)O,,,,val
US20100087427A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2O)C(C)C)ccc1OC.O=C=NCc1ccco1>>COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2OC(=O)NCc2ccco2)C(C)C)ccc1OC,,O,,CC#N,CC#N,val
US05264430,CC1=C(C(=O)O)N2C(=O)[C@H](Cl)[C@H]2SC1.[N-]=[N+]=C(c1ccccc1)c1ccccc1>>CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@H](Cl)[C@H]2SC1,,ClCCl,,,,val
US20080269192A1,Fc1ccc(CBr)cc1.OC[C@H]1COCc2nc3cnc4ccccc4c3n21>>Fc1ccc(COC[C@H]2COCc3nc4cnc5ccccc5c4n32)cc1,,CCOC(C)=O,,[H-].[Na+],,val
US20050148656A1,CCOC(=O)[C@H](Cc1ccc(OCC(=O)O)cc1)OCC.Fc1ccc(CNCC2CCCCC2)c(F)c1>>CCOC(=O)[C@H](Cc1ccc(OCC(=O)N(Cc2ccc(F)cc2F)CC2CCCCC2)cc1)OCC,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20040209865A1,CCO/C=C/C(=O)Nc1ccc(Br)cc1>>O=c1ccc2cc(Br)ccc2[nH]1,,O=S(=O)(O)O,,,,val
US05294612,N#Cc1nn(C(N)=O)c(N)c1C#N>>N#Cc1n[nH]c(N)c1C#N,,O,,,,val
US20020147205A1,CCCC[Sn](CCCC)(CCCC)c1ccc(C2OCCO2)o1.Clc1cc2c(Nc3ccc(OCc4ccccc4)cc3)ncnc2cn1>>O=Cc1ccc(-c2cc3c(Nc4ccc(OCc5ccccc5)cc4)ncnc3cn2)o1,,Cl,,,,val
US05747517,CC(C)(C)c1ccc(COc2ccc(C=O)cc2)cc1.O=C1CSC(=S)N1>>CC(C)(C)c1ccc(COc2ccc(C=C3SC(=S)NC3=O)cc2)cc1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20040248884A1,CC(C)(NC(=O)Nc1ccc(SC(F)(F)F)cc1)C(=O)[O-]>>CC1(C)NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O,,C1COCCO1,Cl,,,val
US20090230857A1,Brc1cccc(-n2c3ccccc3c3ncccc32)c1.CC1(C)OB(c2c3ccccc3c(-c3ccccc3)c3ccccc23)OC1(C)C>>c1ccc(-c2c3ccccc3c(-c3cccc(-n4c5ccccc5c5ncccc54)c3)c3ccccc23)cc1,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20080207654A1,BrCCc1ccccc1.CCCCc1n[nH]c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1>>CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20020169191A1,CON.[N-]=[N+]=NC[C@@H]1CN(c2ccc(C(=O)Oc3c(F)c(F)c(F)c(F)c3F)c(F)c2)C(=O)O1>>CONC(=O)c1ccc(N2C[C@@H](CN=[N+]=[N-])OC2=O)cc1F,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20090312369A1,CC(C)(C)OC(=O)N1CCC[C@@H]([C@@H](O)c2cccc(Cl)c2)C1.CCOC(=O)CBr>>CCOC(=O)CO[C@@H](c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],[Cl-].[NH4+],val
US20070259916A1,CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)O.CCOC(C)=O>>COC(=O)[C@H]1CCCCN1C(=O)OC(C)(C)C,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20100041684A1,CSc1cc(Oc2ccc([N+](=O)[O-])cc2)ncn1>>CSc1cc(Oc2ccc(N)cc2)ncn1,[Pd],C1CCOC1,CCO,,,val
US20070197478A1,CCOC(=O)Nc1cc(C(F)(F)F)nc(NCc2ccccc2)c1N>>O=c1[nH]c2cc(C(F)(F)F)nc(NCc3ccccc3)c2[nH]1,,CC(=O)O,,,,val
US20150225449A1,C[C@H]1[C@H](NC(=O)OC(C)(C)C)C(=O)Nc2ccccc2N1C(=O)C1CCOCC1.Cl>>C[C@H]1[C@H](N)C(=O)Nc2ccccc2N1C(=O)C1CCOCC1.Cl,,C1COCCO1,,,,val
US20130274179A1,Cc1ccc(N)nc1.O=Cc1cc(C2CC2)c([N+](=O)[O-])cc1[N+](=O)[O-]>>Cc1ccc(-n2cc3cc(C4CC4)c([N+](=O)[O-])cc3n2)nc1,,CCO,ClCCl,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04675186,CC(=O)c1csc(-c2ccccc2)n1.O>>O=CC(=O)c1csc(-c2ccccc2)n1,,O,,CC(=O)O,,val
US05112867,COCOc1ccc(C(c2ccc(OCOC)cc2)c2ccccc2N(C)C(=O)C2CCCCC2)cc1>>CNC(=O)C1CCCCC1,,CCOC(C)=O,Cl,,,val
US20100190983A1,CCc1ncnc(Sc2ccc(Cl)cc2)c1F.O=C1CCC(=O)N1Br>>CC(Br)c1ncnc(Sc2ccc(Cl)cc2)c1F,,CC(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20030207857A1,CSc1ccc(N)cc1Cl.O=N[O-]>>CSc1ccc(O)cc1Cl,,C1CCOC1,O,O=S(=O)(O)O,,val
US09321800B2,C[Si](C)(C)C#Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c12>>C#Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c12,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20030096793A1,C=CCC[Si](C)(c1ccccc1)C1(CC(C)C)SCCCS1.O>>C=CCC[Si](C)(C(=O)CC(C)C)c1ccccc1,Cl[Hg]Cl,CC#N,,,,val
US20060160864A1,O=Cc1cc(Br)ccc1F.OCC1CCNC1>>O=Cc1cc(Br)ccc1N1CCC(CO)C1,,CS(C)=O,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US06362177B1,ClCc1ccc(Cl)cc1.NCC1CCNCC1>>NCC1CCN(Cc2ccc(Cl)cc2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160168123A1,COC(=O)c1cncc(B2OC(C)(C)C(C)(C)O2)c1.Cc1cnn(Cc2ccc(CBr)cc2)c1>>COC(=O)c1cncc(Cc2ccc(Cn3cc(C)cn3)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US20130338134A1,CNC(=O)c1cc2c3c(cnc2n1S(=O)(=O)c1ccccc1)CN(c1cc(OC)cc(OC)c1)C(=O)N3C>>CNC(=O)c1cc2c3c(cnc2[nH]1)CN(c1cc(OC)cc(OC)c1)C(=O)N3C,,C1CCOC1,CO,CC(C)(C)[O-].[K+],,val
US20090324581A1,CC(C)(C)OC(=O)CCN(CC(=O)N1CCc2cc(O)ccc21)C(=O)OC(C)(C)C.CC(C)Cc1ccc(CCl)cc1OC(F)(F)F>>CC(C)Cc1ccc(COc2ccc3c(c2)CCN3C(=O)CN(CCC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1OC(F)(F)F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140350032A1,Cc1ccc(NC(=O)/C=C/[C@@]23CC[C@]4(C)[C@H](CC[C@@H]5[C@@]6(C)CC[C@H](OC(=O)CC(C)(C)C(=O)OC(C)(C)C)C(C)(C)[C@@H]6CC[C@]54C)C2=C(C(C)C)C(=O)C3)cc1>>Cc1ccc(NC(=O)/C=C/[C@@]23CC[C@]4(C)[C@H](CC[C@@H]5[C@@]6(C)CC[C@H](OC(=O)CC(C)(C)C(=O)O)C(C)(C)[C@@H]6CC[C@]54C)C2=C(C(C)C)C(=O)C3)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080269196A1,CC(C)(C)CCN.COC(=O)Cc1ccc(C#N)cc1>>CC(C)(C)CCNC(=O)Cc1ccc(C#N)cc1,,C1CCOC1,CCOC(C)=O,CC(C)C[AlH]CC(C)C,,val
US20040220191A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.Clc1ccc(Br)nc1>>OC1(c2ccc(Cl)cn2)CCNCC1,,CCOCC,,O,[Li]CCCC,val
US04191840,CCOC(=O)C(=O)Nc1cccc(SC)c1C(N)=O.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)C(=O)Nc1cccc(S(C)=O)c1C(N)=O,,O,,ClCCl,O=C([O-])O.[Na+],val
US04638075,CC(=O)CC(=O)C(F)(F)F.Nc1nc(NS(=O)(=O)c2ccccc2Cl)n[nH]1>>Cc1cc(C(F)(F)F)n2nc(NS(=O)(=O)c3ccccc3Cl)nc2n1,,CC(=O)O,,O,,val
US20060189657A1,CCC(NC(=O)OC(C)(C)C)[C@H](OC(C)=O)C(=O)O.NNC(=O)c1ccc(OC(F)(F)F)cc1>>CCC(NC(=O)OC(C)(C)C)[C@H](OC(C)=O)C(=O)NNC(=O)c1ccc(OC(F)(F)F)cc1,,ClCCl,,,,val
US20060211696A1,BrBr.CCC(CO)Nc1ccncn1>>CCC(CO)Nc1ncncc1Br,,CC(=O)O,,[Na+].[OH-],,val
US20130210768A1,CC1(C)OB(c2ccccc2C#N)OC1(C)C.Cn1c(=O)[nH]c2ccc(Cl)nc21>>Cn1c(=O)[nH]c2ccc(-c3ccccc3C#N)nc21,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,CO,,O=C([O-])O.[Na+],,val
US20100022555A1,Cc1ccc(C(=O)N2CCNC[C@@H]2C)cn1.O=S(=O)(Cl)c1ccc(OC(F)F)cc1>>Cc1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc(OC(F)F)cc3)C[C@@H]2C)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20030139473A1,COC(=O)Cc1ccc(O)cc1.OCC=C(c1ccc(Br)cc1)c1ccc(Br)cc1>>COC(=O)Cc1ccc(OCC=C(c2ccc(Br)cc2)c2ccc(Br)cc2)cc1,,C1CCOC1,,CCCCP(CCCC)CCCC,,val
US20040198728A1,COc1ccc(Cl)cc1B(O)O.Clc1cc(Cl)nc(Cl)c1>>COc1ccc(Cl)cc1-c1cc(Cl)cc(Cl)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,[Cs+].[F-],,val
US05081121,CCI.CCOc1cc2[nH]ccc(=O)c2cc1OC>>CCOc1cc2c(cc1OC)c(=O)ccn2CC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050148627A1,CCOC(=O)C1=Cc2cc(Cl)c(Oc3ccc(N)cc3F)cc2OC1C(F)(F)F>>Nc1ccc(Oc2cc3c(cc2Cl)C=C(C(=O)O)C(C(F)(F)F)O3)c(F)c1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20100120763A1,COc1cc(F)c([N+](=O)[O-])c(-n2cc(C)nc2Br)c1>>COc1cc(F)c(N)c(-n2cc(C)nc2Br)c1,[Fe],CCO,,CC(=O)O,,val
US20140024694A1,C[C@@H](N)c1cccc(C#N)c1.C[Si](C)(C)C#Cc1c(F)ccc(C#N)c1C(F)(F)F>>C[C@H](c1cccc(C#N)c1)n1ccc2c(C(F)(F)F)c(C#N)ccc21,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20050277655A1,C[Mg]Br.O=Cc1cnc(Cl)nc1Cl>>CC(O)c1cnc(Cl)nc1Cl,,C1CCOC1,,,,val
US20160060273A1,COC(=O)c1cc(C2CC2)c(C2CCC2)cc1OC>>COc1cc(C2CCC2)c(C2CC2)cc1C=O,,C1CCOC1,,[H-].[Na+],,val
US20090093492A1,CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2c(Cl)ccc(N)c2O)CC1.[N-]=[N+]=NC(=O)c1cccc(Cl)c1F>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2c(Cl)ccc(NC(=O)Nc3cccc(F)c3Cl)c2O)CC1,,CCOC(C)=O,,CN(C)C=O,,val
US20050208582A1,N#Cc1cc2c(/C=C/c3cccc(F)c3)n[nH]c2cc1F.O=S(=O)(O)O>>O=C(O)c1cc2c(/C=C/c3cccc(F)c3)n[nH]c2cc1F,,O,,CC(=O)O,,val
US20150152047A1,O=C(NCc1cc(Cl)ccc1Sc1ccccc1)c1cc(Cl)cc(C(F)(F)F)c1.O=C(OO)c1cccc(Cl)c1>>O=C(NCc1cc(Cl)ccc1S(=O)c1ccccc1)c1cc(Cl)cc(C(F)(F)F)c1,,CCOC(C)=O,,,,val
US06080754,C#CC(C)=O.CCc1c(-c2ccc(OCc3ccccc3)cc2)cn2cc(OCc3ccccc3)ccc12>>CCc1c(-c2ccc(OCc3ccccc3)cc2)c2cc(C(C)=O)c3c(OCc4ccccc4)ccc1n23,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20070060566A1,CN.O=C(O)c1cnc(C(=O)Nc2ccc3c(c2)CCN(C2CCC2)CC3)cn1>>CNC(=O)c1cnc(C(=O)Nc2ccc3c(c2)CCN(C2CCC2)CC3)cn1,,CN(C)C=O,,,,val
US05264439,BrCc1ccccc1.CCCCc1n[nH]c(=O)n1Cc1ccc(OC(C(=O)OC)c2ccccc2Cl)cc1>>CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05175311,C=Cc1ccccc1.CC(C)C1CCC(C)(OC(=O)C=[N+]=[N-])CC1>>CC(C)C1CCC(C)(OC(=O)C2CC2c2ccccc2)CC1,,ClCCl,,,,val
US20120101080A1,O=C(Cl)CCCc1ccccc1.c1ccc(C2CCN2)cc1>>O=C(CCCc1ccccc1)N1CCC1c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20050239841A1,C=Cc1ccc(OC)c(OC(F)(F)F)c1.O=[Os](=O)(=O)=O>>COc1ccc(C=O)cc1OC(F)(F)F,O=[Os](=O)(=O)=O,C1CCOC1,,O,,val
US04220761,C=CCON=C(C(=O)OCC)c1csc(N)n1>>C=CCON=C(C(=O)O)c1csc(N)n1,,CO,,C1CCOC1,[Na+].[OH-],val
US20130005707A1,COc1cc(Cl)cc(B(O)O)c1>>OB(O)c1cc(O)cc(Cl)c1,,ClCCl,,BrB(Br)Br,,val
US20050272763A1,CC(=O)OCC(=O)Cl.CC(C)(O)C(=O)c1oc2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)cc2c1N>>CC(=O)OCC(=O)Nc1c(C(=O)C(C)(C)O)oc2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)cc12,,CC#N,ClCCl,,,val
US05196454,CCCCI.CCCNC1CCc2c(cccc2NC(C)=O)C1.Cl>>CCCCN(CCC)C1CCc2c(cccc2NC(C)=O)C1.Cl,,C1CCOC1,CN(C)C=O,O=C([O-])O.[Na+],,val
US20130079324A1,C=CC(=O)Cl.Cn1cc(Nc2nc(N[C@H]3C[C@H](N)C3)c3ccn(COCC[Si](C)(C)C)c3n2)cn1>>C=CC(=O)N[C@@H]1C[C@@H](Nc2nc(Nc3cnn(C)c3)nc3c2ccn3COCC[Si](C)(C)C)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20050228015A1,Cc1cc(C)cc(CO)c1.O=[N+]([O-])c1ccc(S)cc1>>Cc1cc(C)cc(CSc2ccc([N+](=O)[O-])cc2)c1,,C1CCOC1,CCOC(C)=O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060189601A1,COc1ccc2ncc(Cl)c(N3CCC(CCNC(=O)OC(C)(C)C)CC3)c2c1>>COc1ccc2ncc(Cl)c(N3CCC(CCN)CC3)c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05155117,CCCCc1nc(CCCC)n(Cc2ccc(Br)cn2)n1.OB(O)c1ccccc1-c1nnnn1C(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cn2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20060166990A1,Cc1ccc(N)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl.O=C=NCc1ccccc1>>Cc1ccc(NC(=O)NCc2ccccc2)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl,,c1ccncc1,,,,val
US20100331326A1,COc1ccc(Br)cc1F.Cc1ccncc1N1CCNC1=O>>COc1ccc(N2CCN(c3cnccc3C)C2=O)cc1F,I[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20100105655A1,COC(=O)C(C#N)c1ccc([N+](=O)[O-])c(OC)c1>>COc1cc(C(CN)CO)ccc1[N+](=O)[O-],,C1CCOC1,,O=C([O-])O.[Na+],,val
US06448270B1,C#CCCS(C)(=O)=O.c1ccc(CC2CCNCC2)cc1>>C#CCCN1CCC(Cc2ccccc2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080009530A1,CC(C)(C)OC(=O)CBr.CCOC(=O)CCc1cc(O)nn1Cc1ccc(Cl)cc1Cl>>CCOC(=O)CCc1cc(OCC(=O)OC(C)(C)C)nn1Cc1ccc(Cl)cc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120202785A1,CO.C[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(F)cc1Nc1ccc(F)nc1>>COc1ccc(-n2c([C@H](C)NC(=O)OC(C)(C)C)nc3ccc(F)cc32)cn1,,CO,,C[O-].[Na+],,val
US20110034464A1,Cl.N#CC(C(N)=O)C1OC(=O)C(Cl)=C1Cl.NCc1cc(F)ccc1S(N)(=O)=O>>Cl.N=c1c(C(N)=O)cc(Cl)cn1Cc1cc(F)ccc1S(N)(=O)=O,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20140294898A1,NCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.O=C(Cl)c1ccccc1>>O=C(N[C@@H](CCNC(=O)c1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21,,C1CCOC1,,[Na+].[OH-],,val
US20100173912A1,N#Cc1cc(F)ccc1N1CCNCC1.O=C(O)COCc1ccc(F)cc1>>N#Cc1cc(F)ccc1N1CCN(C(=O)COCc2ccc(F)cc2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06136848,CC(C)Br.COC(=O)c1cccc(O)c1>>COC(=O)c1cccc(OC(C)C)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160038504A1,Cc1ncc(Br)cc1N1CCOCC1.O=C1CCOCC1>>OC1(Cc2ncc(Br)cc2N2CCOCC2)CCOCC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20060189825A1,CCc1ccc(C=O)o1.NNC(=O)c1ccc(O)cc1>>CCc1ccc(C=NNC(=O)c2ccc(O)cc2)o1,CC(=O)O,CCO,,,,val
US20110160255A1,Cn1nccc1-c1nc(C(=O)O)co1.N[C@@H](Cc1cccc(F)c1)CN1C(=O)c2ccccc2C1=O>>Cn1nccc1-c1nc(C(=O)N[C@@H](Cc2cccc(F)c2)CN2C(=O)c3ccccc3C2=O)co1,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US04840943,C[C@@]12C(=CC(=O)[C@H]3CC31)CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12.O=C1CCC(=O)N1Br>>C[C@@]12C(=CC(=O)[C@H]3CC31)[C@H](Br)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20150105373A1,CC(C)(O)C(NC(=O)N1CC(=O)N(COCC[Si](C)(C)C)c2cc(O)cnc21)c1ccc(OC(F)(F)F)cc1.CI>>COc1cnc2c(c1)N(COCC[Si](C)(C)C)C(=O)CN2C(=O)NC(c1ccc(OC(F)(F)F)cc1)C(C)(C)O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20040162287A1,CN(C)C1(c2ccccc2)CCC(=O)CC1.NCc1c[nH]c2ccccc12>>CN(C)C1(c2ccccc2)CCC(NCc2c[nH]c3ccccc23)CC1,,C1CCOC1,ClCCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060004017A1,COc1cc2c(=O)[nH]cnc2cc1OCCCN(C)S(C)(=O)=O.O=S(Cl)Cl>>COc1cc2c(Cl)ncnc2cc1OCCCN(C)S(C)(=O)=O,CN(C)C=O,,,,,val
US20120184553A1,Nc1ccnnc1.O=C(O)c1cc(Br)ccc1OCc1ccc(F)c(F)c1>>O=C(Nc1ccnnc1)c1cc(Br)ccc1OCc1ccc(F)c(F)c1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04492598,Cc1cc(C)nc(N)n1.O=C=NS(=O)(=O)C1CC2C=CC1O2>>Cc1cc(C)nc(NC(=O)NS(=O)(=O)C2CC3C=CC2O3)n1,,ClCCl,,CCCCCC,,val
US20070010564A1,CC(C)(C)CC(C)(C)NS(=O)(=O)/C=C/c1cccnc1>>NS(=O)(=O)/C=C/c1cccnc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04332809,COc1cc(C(=O)O)nc(-c2ccc(N(C)C)cc2)c1.Nc1nnn[nH]1>>COc1cc(C(=O)Nc2nnn[nH]2)nc(-c2ccc(N(C)C)cc2)c1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20150218096A1,COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C(=O)N4CCOCC4)ccc23)cc1>>O=C(O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C(=O)N4CCOCC4)ccc23)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20110118245A1,CC(F)(F)c1cc(N)n(-c2ccccc2)n1.O=C(Cl)Oc1ccccc1>>CC(F)(F)c1cc(NC(=O)Oc2ccccc2)n(-c2ccccc2)n1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US05374772,CCCCCCCCCCCCCCCCCCBr.COC(=O)c1ccc(O)cc1O>>CCCCCCCCCCCCCCCCCCOc1ccc(C(=O)OC)c(O)c1,,CC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20030187026A1,Cc1n[nH]c2ccc(-c3cc(OC[C@H](Cc4ccccc4)NC(=O)OC(C)(C)C)ccc3C=O)cc12>>Cc1n[nH]c2ccc(-c3cc(OC[C@H](Cc4ccccc4)NC(=O)OC(C)(C)C)ccc3CO)cc12,,CCO,O,[BH4-].[Na+],,val
US06441017B1,CC(=O)N1CC(N)=Cc2c1cccc2[N+](=O)[O-]>>Nc1cnc2cccc([N+](=O)[O-])c2c1,,CCO,,O,[K+].[OH-],val
US06110945,CCOC(=O)CN=C(c1ccccc1)c1ccccc1.O=S(=O)(Oc1ccc(CBr)nc1)c1ccccc1>>CCOC(=O)C(Cc1ccc(OS(=O)(=O)c2ccccc2)cn1)N=C(c1ccccc1)c1ccccc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20130317110A1,BrCc1ccccc1.Nc1ccc2c(c1F)CCC2=O>>O=C1CCc2c1ccc(NCc1ccccc1)c2F,,CC#N,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150361069A1,CC(C)(C)S(=O)(=O)c1cc2c(O)ncnc2cc1F.Cc1[nH]nc(N)c1C.O=P(Cl)(Cl)Cl>>Cc1[nH]nc(Nc2ncnc3cc(F)c(S(=O)(=O)C(C)(C)C)cc23)c1C.Cl,,CC#N,,,,val
US20140256734A1,CN(c1nc(-c2n[nH]c(=O)[nH]2)cc2ccccc12)[C@H]1CCN(C(=O)OC(C)(C)C)C1>>CN(c1nc(-c2n[nH]c(=O)[nH]2)cc2ccccc12)[C@H]1CCNC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160235734A1,CN1CC[C@@H](OC(=O)C(O)(c2ccccc2)c2cccc(C(=O)NCCCCN(C[C@H](O[Si](C)(C)C(C)(C)C)c3ccc(OCc4ccccc4)c4[nH]c(=O)ccc34)C(=O)OC(C)(C)C)c2)C1>>CN1CC[C@@H](OC(=O)C(O)(c2ccccc2)c2cccc(C(=O)NCCCCN(C[C@H](O[Si](C)(C)C(C)(C)C)c3ccc(O)c4[nH]c(=O)ccc34)C(=O)OC(C)(C)C)c2)C1,[Pd],,,O=CO,,val
US20080312291A1,CCOC(=O)[C@H](C#N)NC(=O)C(C)C>>CCOC(=O)c1nc(C(C)C)oc1N,,Cl,,,,val
US20140336415A1,Nc1ccc(Cl)cc1.O=[N+]([O-])c1c(Cl)cccc1Cl>>O=[N+]([O-])c1c(Cl)cccc1Nc1ccc(Cl)cc1,,C1CCOC1,O,Cl,[H-].[Na+],val
US20120220588A1,CNS(=O)(=O)c1ccc(Cl)c([N+](=O)[O-])c1>>CNS(=O)(=O)c1ccc(Cl)c(N)c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20090012147A1,NC(=O)CBr.O=C1Nc2ccc(Cl)cc2C1(F)F>>NC(=O)CN1C(=O)C(F)(F)c2cc(Cl)ccc21,,CN(C)C=O,,O,[H-].[Na+],val
US20110105530A1,Nc1cc(C(=O)NCc2ccccc2)ccn1.O=C(Cl)c1ccccc1F>>O=C(NCc1ccccc1)c1ccnc(NC(=O)c2ccccc2F)c1,CN(C)c1ccncc1,ClCCl,c1ccncc1,,,val
US20090312336A1,CCOc1cc(C(=O)NC2CCN(C)CC2)ccc1[N+](=O)[O-]>>CCOc1cc(C(=O)NC2CCN(C)CC2)ccc1N,[Pd],CO,,,,val
US20110065766A1,CC(C)(C)OC(=O)NC12CC3CC(CC(C3)C1=O)C2.[Li]C>>CC(C)(C)OC(=O)NC12CC3CC(CC(C3)C1(C)O)C2,,C1CCOC1,,,,val
US20070287696A1,O=C(Nc1cc(I)cn(CC2CC2)c1=O)OCc1ccccc1.OB(O)c1ccccc1>>O=C(Nc1cc(-c2ccccc2)cn(CC2CC2)c1=O)OCc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,CCO,O=C([O-])[O-].[Na+].[Na+],,val
US20110212103A1,N#CCC1(COc2ncccc2[N+](=O)[O-])CC1>>N#CCC1(COc2ncccc2N)CC1,,CC(=O)O,CCO,,,val
US20140243334A1,COC(=O)C1CCc2ccc(-c3cccc(NC(=O)OC(C)(C)C)c3)cc2C1.Cl>>COC(=O)C1CCc2ccc(-c3cccc(N)c3)cc2C1.Cl,,ClCCl,,C1COCCO1,,val
US04521428,Cc1cccc(CCCl)n1.Cl.FC(F)(F)c1cccc(C2=CCNCC2)c1>>Cc1cccc(CCN2CC=C(c3cccc(C(F)(F)F)c3)CC2)n1.Cl,,CCO,,CCN(CC)CC,,val
US20150307493A1,CNC(=O)CN1C(=O)C(C(C)C)Oc2c(Br)cc(OC)cc21.Cc1ccc(S(=O)(=O)n2ccc3c(B4OC(C)(C)C(C)(C)O4)cn(C)c(=O)c32)cc1>>CNC(=O)CN1C(=O)C(C(C)C)Oc2c(-c3cn(C)c(=O)c4c3ccn4S(=O)(=O)c3ccc(C)cc3)cc(OC)cc21,,C1COCCO1,O,ClCCl,O=C([O-])[O-].[K+].[K+],val
US05041455,CI.COc1nsnc1-c1cccnc1>>COc1nsnc1-c1ccc[n+](C)c1.[I-],,CC(C)=O,,,,val
US06538015B1,CC(C)n1nc(CO)c(COCc2ccncc2)c1Sc1cc(Cl)cc(Cl)c1.O=C=NC(=O)C(Cl)(Cl)Cl>>CC(C)n1nc(COC(N)=O)c(COCc2ccncc2)c1Sc1cc(Cl)cc(Cl)c1,,ClCCl,,,,val
US20110136780A1,CC[C@@H](C)[C@@H](NC(=O)OC(C)(C)C)C(=O)O.NC1CCCC1>>CC[C@@H](C)[C@@H](NC(=O)OC(C)(C)C)C(=O)NC1CCCC1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030171334A1,CC(C)=O.CC1=C[C@]23C(=O)[C@@H](C=C(CO)[C@@H](O)[C@]2(O)[C@H]1O)[C@H]1[C@@H](C[C@H]3C)C1(C)C>>CC1=CC23C(=O)C(C=C4COC(C)(C)O[C@H]4[C@]2(O)[C@H]1O)C1C(C[C@H]3C)C1(C)C,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20160264598A1,CCCCO.O=C(CCc1nccs1)N[C@H]1Cc2cccc(C(=O)O)c2OB1O>>CCCCOC(=O)c1cccc2c1OB(O)[C@@H](NC(=O)CCc1nccs1)C2,,CCCCO,,,,val
US20040116328A1,CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2nc(Cl)nc(Cl)c21.CS(C)=O>>CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2nc(Cl)[nH]c(=O)c21,,CS(C)=O,,CC(=O)[O-].[Na+],,val
US04147780,CC=O.O=[PH2][O-].[NH3+]C(c1ccccc1)c1ccccc1>>CC(NC(c1ccccc1)c1ccccc1)P(O)O,,C1COCCO1,,,,val
US20070142357A1,CC(Cl)C(=O)Cl.NCCc1ccc(Cl)cc1Cl>>CC(Cl)C(=O)NCCc1ccc(Cl)cc1Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040102484A1,Cc1cc(C)cc(OCC(=O)O)c1.O=S(Cl)Cl>>Cc1cc(C)cc(OCC(=O)Cl)c1,,c1ccccc1,,,,val
US05391743,COC(=O)c1ccc2cc[nH]cc1-2>>COC(=O)C1=C2CNCC=C2C=C1,[Pd],CO,,[H][H],,val
US20080234455A1,CC(=O)OO.CC1=CCC(CO)CC1>>CC12CCC(CO)CC1O2,,CCOC(C)=O,,,,val
US20160016880A1,CCOC(=O)C(C)=P(c1ccccc1)(c1ccccc1)c1ccccc1.COC12CCC(CC=O)(CC1)C2>>CCOC(=O)/C(C)=C/CC12CCC(OC)(CC1)C2,,C1CCOC1,,,,val
US04469868,CC(N)CN.Cc1nn(C)c(C#N)c1[N+](=O)[O-]>>Cc1nn(C)c(C2=NC(C)CN2)c1[N+](=O)[O-],,Clc1ccccc1Cl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20090005376A1,CCOn1cnc2cnc3ccccc3c21.O=C(OO)c1cccc(Cl)c1>>CCOn1cnc2c[n+]([O-])c3ccccc3c21,,ClCCl,,O=C([O-])O.[Na+],,val
US20040259875A1,CC(=O)OC(C)=O.Nc1c(Cl)cc(Cl)c2ccc(O)cc12>>CC(=O)Oc1ccc2c(Cl)cc(Cl)c(N)c2c1,,ClCCl,,O,c1ccncc1,val
US05602160,C1CCNC1.C=O.CCCC(=O)c1cc(-c2ccccc2)no1.Cl>>CCC(CN1CCCC1)C(=O)c1cc(-c2ccccc2)no1.Cl,,C1COCCO1,,Cl,,val
US20070208018A1,COC(=O)c1cn(-c2cc(C(=O)OC)c([N+](=O)[O-])cc2C(F)(F)F)cn1>>COC(=O)c1cn(-c2cc(C(=O)OC)c(N)cc2C(F)(F)F)cn1,[Pd],CO,,,,val
US20140243302A1,COc1ccc2ncc(F)c(CC(O)C34CCC(NC(=O)OC(C)(C)C)(CC3)CO4)c2n1>>COc1ccc2ncc(F)c(CC(=O)C34CCC(NC(=O)OC(C)(C)C)(CC3)CO4)c2n1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20110118245A1,CCOC(C)(C)c1cc(NC(=O)Oc2ccccc2)n(-c2ccccc2)n1.COCCOc1cc2ncnc(Sc3cccc(N)c3)c2cc1OC>>CCOC(C)(C)c1cc(NC(=O)Nc2cccc(Sc3ncnc4cc(OCCOC)c(OC)cc34)c2)n(-c2ccccc2)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20050124626A1,O=C(N1CCN(c2ccccc2[N+](=O)[O-])CC1)C(F)(F)F>>Nc1ccccc1N1CCN(C(=O)C(F)(F)F)CC1,[Pd],CCO,,,,val
US20100076014A1,CC(C)(C(=O)Nc1nccs1)C(c1ccccc1)c1ccc2[nH]ccc2c1.O=C=NS(=O)(=O)Cl>>CC(C)(C(=O)Nc1nccs1)C(c1ccccc1)c1ccc2[nH]cc(C#N)c2c1,,CC#N,,CN(C)C=O,,val
US05679689,Cl.N[C@@]12C=CC=C[C@@H]1CN(c1c(F)cc3c(=O)c(C(=O)O)cn([C@@H]4C[C@@H]4F)c3c1Cl)C2>>Cl.N[C@@]12C=CC=C[C@@H]1CN(c1c(F)cc3c(=O)c(C(=O)O)cn([C@@H]4C[C@@H]4F)c3c1Cl)C2,,Cl,O,,,val
US05338742,CCCCBr.Oc1ccc(CCCc2ccncc2)cc1>>CCCCOc1ccc(CCCc2ccncc2)cc1,,[Na+],[OH-],,,val
US20030069438A1,CO.C[C@@H]1CC[C@@](CC(=O)O)(Cc2ccccc2)C1>>COC(=O)C[C@@]1(Cc2ccccc2)CC[C@@H](C)C1,,CO,Cc1ccccc1,C[Si](C)(C)C=[N+]=[N-],,val
US20090197863A1,CCC=O.NC(=O)c1cccc2nc(-c3ccc(C4CCCCN4)cc3F)oc12>>CCCN1CCCCC1c1ccc(-c2nc3cccc(C(N)=O)c3o2)c(F)c1,[Pd],CO,,,,val
US05571813,CCc1cc(Cl)n2nccc2n1.CNCc1ccc(-c2ccccc2C#N)cc1>>CCc1cc(N(C)Cc2ccc(-c3ccccc3C#N)cc2)n2nccc2n1,,CCO,O,CCN(CC)CC,,val
US20030149001A1,CC1CN(c2ccc(N)nc2)CC(C)O1.Cc1c(Br)c(=O)n(C2CCCC2)c2nc(S(C)=O)ncc12>>Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(N4CC(C)OC(C)C4)cn3)ncc12,,Cc1ccccc1,,,,val
US20040102450A1,Clc1ccnc(Cl)n1.O=C1CN(S(=O)(=O)c2cc3ccc(Cl)cc3s2)CCN1CC1CCNCC1>>O=C1CN(S(=O)(=O)c2cc3ccc(Cl)cc3s2)CCN1CC1CCN(c2ccnc(Cl)n2)CC1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US04064265,O=C(O)CCS.O=[N+]([O-])c1ccc(Oc2ccc(N=C=S)cc2)cc1>>O=C(O)CCSC(=S)Nc1ccc(Oc2ccc([N+](=O)[O-])cc2)cc1,,CN(C)C=O,,O,,val
US20140235702A1,COC(=O)CSc1cc(NS(=O)(=O)c2cccs2)c2ccccc2c1OC.O=C(Cl)Cc1ccc(Cl)cc1>>COC(=O)CSc1cc(NC(=O)Cc2ccc(Cl)cc2)c2ccccc2c1OC,,CCN(CC)CC,,,,val
US20030195210A1,CCCc1nc(C)n2c(=O)[nH]c(-c3cc(S(=O)(=O)Cl)ccc3OCC)nc12.COCCN>>CCCc1nc(C)n2c(=O)[nH]c(-c3cc(S(=O)(=O)NCCOC)ccc3OCC)nc12,,ClCCl,,,,val
US05256824,CC(=O)CC(C=O)(c1ccccc1)c1ccccc1>>O=C1C=CC(c2ccccc2)(c2ccccc2)C1,,C1CCOC1,CO,[K+].[OH-],,val
US09212190B2,CC(C)(C)[Si](C)(C)OC(C#N)C[C@H]1CCc2sc3ncnc(Cl)c3c21.NC1CCC(N2CCOCC2)CC1>>CC(C)(C)[Si](C)(C)OC(C#N)C[C@H]1CCc2sc3ncnc(NC4CCC(N5CCOCC5)CC4)c3c21,,CN1CCCC1=O,ClCCl,CCN(CC)CC,,val
US20140336185A1,CCCCCCCOc1ccc(C(=O)O)cc1.O=Cc1ccc(O)cc1>>CCCCCCCOc1ccc(C(=O)Oc2ccc(C=O)cc2)cc1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US06362181B1,CN1CCNCC1.O=C1c2cccc3c([N+](=O)[O-])c(Br)cc(c23)C(=O)N1OCc1ccccc1>>CN1CCN(c2c(Br)cc3c4c(cccc24)C(=O)N(OCc2ccccc2)C3=O)CC1,,CN(C)C=O,,,,val
US20090221663A1,CCCSc1c(C(=O)NC2CCOCC2)cnn1-c1ccc(C(=O)OC)cc1>>CCCSc1c(C(=O)NC2CCOCC2)cnn1-c1ccc(C(=O)O)cc1,,CO,,[Na+].[OH-],,val
US20110184029A1,CC(=O)OCc1[nH]c(=O)c(C(C)C)c(C(=O)c2cc(C#N)cc(C#N)c2)c1CC1CC1>>CC(C)c1c(C(=O)c2cc(C#N)cc(C#N)c2)c(CC2CC2)c(CO)[nH]c1=O,,CO,,[NH4+].[OH-],,val
US20150057298A1,CCOC(=O)c1ccc(Oc2c(C)cccc2C)cc1>>Cc1cccc(C)c1Oc1ccc(C(=O)O)cc1,,CO,O,Cl,[Na+].[OH-],val
US20120302539A1,CC(C)(C)OC(=O)NC1CCN(S(=O)(=O)c2ccc3c(c2)CCN3C(=O)C2CC2)CC1>>NC1CCN(S(=O)(=O)c2ccc3c(c2)CCN3C(=O)C2CC2)CC1,,C1COCCO1,,Cl,,val
US04923886,CCOC(=O)C(=O)CBr.NC(=S)c1cccc([N+](=O)[O-])c1>>CCOC(=O)c1csc(-c2cccc([N+](=O)[O-])c2)n1,,CCO,,,,val
US20150232474A1,CN1CCCC2(CCNC2)C1.COc1ccc(CNc2nc(S(C)=O)ncc2C(=O)NCc2ncccn2)cc1Cl>>COc1ccc(CNc2nc(N3CCC4(CCCN(C)C4)C3)ncc2C(=O)NCc2ncccn2)cc1Cl,,C1CCOC1,ClCCl,CCN(CC)CC,O,val
US20120302752A1,CCN(CC)C(=O)c1ccccc1OC.COc1ccc(B2OCC(C)(C)CO2)cc1>>CCN(CC)C(=O)c1ccccc1-c1ccc(OC)cc1,,Cc1ccccc1,,,,val
US20140221310A1,CC1(C)OB(c2cnc(N)nc2)OC1(C)C.Nc1cnc(-c2ccc(C3CCC3)c(Oc3ncc(Br)cn3)c2F)cn1>>Nc1cnc(-c2ccc(C3CCC3)c(Oc3ncc(-c4cnc(N)nc4)cn3)c2F)cn1,,C1COCCO1,O,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20110183974A1,CC(C)(C)OC(=O)N1CCN(c2nc(-c3nc4ccccc4[nH]3)no2)CC1.CI>>Cn1c(-c2noc(N3CCN(C(=O)OC(C)(C)C)CC3)n2)nc2ccccc21,,CC(C)=O,,[K+].[OH-],,val
US20040157866A1,CI.O=C(O)c1ccccc1-c1ccc(I)cc1>>COC(=O)c1ccccc1-c1ccc(I)cc1,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20120245172A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(C(O)CNCCO)cnc1Br>>Cc1cc(C(O)CN(CCO)C(=O)OC(C)(C)C)cnc1Br,,C1CCOC1,,CCOC(C)=O,,val
US20110237573A1,CC(=O)N1CCN(c2ccc(N)nc2)CC1.O=C(O)Cc1ccc(I)cc1>>CC(=O)N1CCN(c2ccc(NC(=O)Cc3ccc(I)cc3)nc2)CC1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080261941A1,CC(C)(C)OC(=O)N1CCC(=Cc2cccc(O)c2)CC1.ClCCl.OB(O)c1ccccc1>>CC1C(Oc2ccccc2)=CC=CC1=C1CCNCC1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20040198814A1,CC(C)(CO)CCCCCCC(O)CCCCCCC(C)(C)CO>>CC(C)(CO)CCCCCCC(=O)CCCCCCC(C)(C)CO,,CC(=O)O,,[Na+].[O-]Cl,,val
US20040063698A1,CCOC(=O)C(C)(C)C(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1>>CCOC(=O)C(C)(C)C(O)c1ccc(OCc2cc(C)nc3ccccc23)cc1,,CO,,[BH4-].[Na+],,val
US20080227840A1,CC(=O)C1CCCC1=O.NNC(=O)c1ccccc1Cl>>CC1=NN(C(=O)c2ccccc2Cl)C2(O)CCCC12,,CCOC(C)=O,,,,val
US07012144B2,CCOC(=O)C=C(C)c1ccccn1.C[N+](=O)[O-]>>CCOC(=O)CC(C)(C[N+](=O)[O-])c1ccccn1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20110039852A1,CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(F)cc(CC(=O)O)c1)C(=O)OCc1ccccc1>>CCNCc1cc(C(F)(F)F)ccc1-c1cc(F)cc(CC(=O)O)c1,[Pd],CO,,,,val
US06239151B1,CC(C)C[C@@H](C(=O)NN(Cc1ccccc1)C(=O)CCCNC(=O)OCc1ccccc1)[C@H](CCCC1CCCCC1)C(=O)NOC1CCCCO1>>CC(C)C[C@@H](C(=O)NN(Cc1ccccc1)C(=O)CCCN)[C@H](CCCC1CCCCC1)C(=O)NOC1CCCCO1,[Pd],CO,,[H][H],,val
US04444775,CCOC(=O)C(CCCCc1cccc2cncn12)S(=O)c1ccccc1>>CCOC(=O)C=CCCCc1cccc2cncn12,,Cc1ccccc1C,,,,val
US20090062324A1,COC1=C(CCCNC(=O)OC(C)(C)C)Cc2c(ccc(OC)c2OC)C1.Cl>>COc1ccc2c(c1OC)CC1CCCN=C1C2.Cl,,CO,,,,val
US20080249138A1,Cc1ccc(CCl)nc1C#N.OB(O)c1cc(Cl)ccc1OCc1ccc(Cl)cc1F>>Cc1ccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)nc1C#N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US20150210710A1,CS(=O)(=O)CC(=O)O.FC(F)(F)C1(c2cc(Cl)cc(Cl)c2)CC(c2ccc3c(c2)COC32CNC2)=CO1>>CS(=O)(=O)CC(=O)N1CC2(C1)OCc1cc(C3=COC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)ccc12,,C1CCOC1,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US04721788,Cc1ccc(S(=O)(=O)O)cc1.N#CC12CCN(CC1)CC2>>Cc1ccc(S(=O)(=O)O)cc1.N#CC12CCN(CC1)CC2,,CCO,,O,,val
US20060111406A1,CCOC(=O)[C@@H](Cc1ccc(O[C@@H](C)C(=O)OCc2ccccc2)cc1)OCC>>CCOC(=O)[C@@H](Cc1ccc(O[C@@H](C)C(=O)O)cc1)OCC,[Pd],CCO,O,,,val
US20090105212A1,CCCC(O)N(C)C.CCCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(CN(C)CC(=O)OC)cc3OC)c2n1>>CCCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(CN(C)CC(=O)OCCCCN(C)C)cc3OC)c2n1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20130345246A1,CC(=O)C(N)=S.N=C1c2cc(OCCCF)ccc2CC12CCC(O)CC2>>CC1=NC2(NC1=S)c1cc(OCCCF)ccc1CC21CCC(O)CC1,,CO,,,,val
US06114163,CC(=O)O.CC(C)C(N)C(=O)O>>CC(=O)NC(C(=O)O)C(C)C,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20100249078A1,BrCc1ccccc1.O=C(O)CCc1ccc(O)cc1>>O=C(O)CCc1ccc(OCc2ccccc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20160096830A1,CC(C)(C)OC(=O)NCCCC[C@@H](C=O)NC(=O)OCc1ccccc1.c1ccc2scnc2c1>>CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)OCc1ccccc1)C(O)c1nc2ccccc2s1,,C1CCOC1,,[Li]CCCC,,val
US05006544,Cc1c(C=O)ncn1C(c1ccccc1)(c1ccccc1)c1ccccc1.O=C1CCSc2ccccc21>>Cc1c(/C=C2/CSc3ccccc3C2=O)ncn1C(c1ccccc1)(c1ccccc1)c1ccccc1,,CO,,[K+].[OH-],,val
US20090258917A1,Cc1ccc2oc(-c3cc(I)ccc3OC(C)C)nc2c1.NC(=O)c1ccccc1OC(F)(F)F>>Cc1ccc2oc(-c3cc(NC(=O)c4ccccc4OC(F)(F)F)ccc3OC(C)C)nc2c1,[Cu]I,CCOC(C)=O,Cc1ccccc1,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20120046268A1,N#CC1CCN(C(=O)N2CC(N)CC(c3ccc(C(F)(F)F)cc3)C2)CC1.O=C(Cl)C1CCCC1>>N#CC1CCN(C(=O)N2CC(NC(=O)C3CCCC3)CC(c3ccc(C(F)(F)F)cc3)C2)CC1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,Cl,val
US20040019098A1,COc1ccc(CC(=O)Cl)cc1.Nc1ccc2c(c1)C(=C1C(=O)Nc3ccccc31)OC2>>COc1ccc(CC(=O)Nc2ccc3c(c2)C(=C2C(=O)Nc4ccccc42)OC3)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20120040968A1,CC(C)S.Cc1ccc(F)c([N+](=O)[O-])c1>>Cc1ccc(SC(C)C)c([N+](=O)[O-])c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05438052,COC(=O)c1cc(O)c(O)c(Br)c1.O=S(=O)(Cl)Cl>>COC(=O)c1cc(Br)c(O)c(O)c1Cl,,CC(=O)O,,,,val
US20150307489A1,Brc1ccc(Br)nc1.CCOC(=O)C(F)F>>OC(c1ccc(Br)cn1)C(F)F,,Cc1ccccc1,,[Li]CCCC,,val
US20140018313A1,CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H](C2)[C@H]1c1nc2c([nH]1)-c1ccc(Br)cc1CC2>>CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H](C2)[C@H]1c1nc2ccc3cc(Br)ccc3c2[nH]1,,c1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20150299123A1,CC(C)(C)[C@@H]1CC[C@@H](Oc2ccc(-c3cccc(C=O)c3)cc2)CC1.COC(=O)C1CCNCC1>>COC(=O)C1CCN(Cc2cccc(-c3ccc(O[C@@H]4CC[C@@H](C(C)(C)C)CC4)cc3)c2)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100010041A1,CC(C)(C)CCCN1C(c2ccc(C(F)(F)F)cc2)CC(F)(F)C(CC(=O)OC(C)(C)C)C1c1ccc(C(F)(F)F)cc1>>CC(C)(C)CCCN1C(c2ccc(C(F)(F)F)cc2)CC(F)(F)C(CC(=O)O)C1c1ccc(C(F)(F)F)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160185764A1,CCO[P+](=O)OCC.Cc1nc(COS(C)(=O)=O)ccc1Br>>CCOP(=O)(Cc1ccc(Br)c(C)n1)OCC,,CN(C)C=O,,[H-].[Na+],,val
US04447442,CC1CC(NC(=O)C(F)(F)F)=NN1c1ccc(C(=O)C(F)(F)F)cc1.CCC(=O)OC(=O)CC>>CCC(=O)NC1=NN(c2ccccc2)C(C)C1,,O,,,,val
US20080207728A1,N[C@@H](CO)Cc1c[nH]c2ccccc12.O=C(O)c1cc(I)cc2c1OCC=C2>>O=C(N[C@@H](CO)Cc1c[nH]c2ccccc12)c1cc(I)cc2c1OCC=C2,,CN(C)C=O,O,ClCCCl,On1nnc2ccccc21,val
US20150284396A1,CCOCc1nc(N)c2c(n1)c(C#CCCCCN1CCCCC1)cn2COCc1ccccc1>>CCOCc1nc(N)c2[nH]cc(CCCCCCN3CCCCC3)c2n1,[Pd],CO,,[H][H],,val
US05716954,CCCCN1C(=O)c2cccnc2C1(O)c1ccccc1.O=[N+]([O-])O>>CCCCN1C(=O)c2cccnc2C1(O)c1cccc([N+](=O)[O-])c1,,O,,O=S(=O)(O)O,,val
US04946235,O=C1c2ccc([N+](=O)[O-])cc2C(=O)N1c1cccc([N+](=O)[O-])c1>>Nc1cccc(N2C(=O)c3ccc(N)cc3C2=O)c1,O=[Pt],C1CCOC1,,,,val
US20110306607A1,COC(=O)COc1ccc(C(=O)N2CCC3(CC2)Oc2ccccc2-n2cccc23)cc1OC>>COc1cc(C(=O)N2CCC3(CC2)Oc2ccccc2-n2cccc23)ccc1OCC(=O)O,,C1CCOC1,,[Li+].[OH-],,val
US09268065B1,CCCCCCCCBr.N#Cc1ccc(N=Nc2ccc([N+](=O)[O-])cc2O)cc1>>CCCCCCCCOc1cc(N)ccc1N=Nc1ccc(C#N)cc1,,CC(C)=O,CCO,O,O=C([O-])[O-].[K+].[K+],val
US20040209901A1,Cc1cc(F)ccc1-c1nc(S(C)(=O)=O)nc2c1ccc(=O)n2-c1ccccc1F.NC1CCOCC1>>Cc1cc(F)ccc1-c1nc(NC2CCOCC2)nc2c1ccc(=O)n2-c1ccccc1F,,C1CCOC1,,,,val
US20050239751A1,C#Cc1cccc(NCc2oc(=O)oc2C2CCCN2C(=O)OC(C)(C)C)c1.O=C(Cl)C(Cl)Cl>>C#Cc1cccc(N(Cc2oc(=O)oc2C2CCCN2C(=O)OC(C)(C)C)C(=O)C(Cl)Cl)c1,,ClCCl,,CCN(CC)CC,,val
US20080280924A1,CC(C)(C)NS(=O)(=O)c1cccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)nc4)cc(C(F)F)n3)c2)c1>>NS(=O)(=O)c1cccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)nc4)cc(C(F)F)n3)c2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080139631A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2c(nc(C(F)(F)F)n2CC(F)(F)F)c1Cl>>O=S(=O)(Oc1ccc2c(nc(C(F)(F)F)n2CC(F)(F)F)c1Cl)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US20120101297A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@@H]1C=C[C@H](N)C1>>COC(=O)[C@@]1(N)C=C[C@H](C(=O)OC(C)(C)C)C1,,ClCCl,,CCN(CC)CC,Cl,val
US20030027823A1,ClC/C=C\CCl.O=c1[nH]c2ccccc2n1CCOC1CCCCO1>>O=c1n(C/C=C\CCl)c2ccccc2n1CCOC1CCCCO1,,CN(C)C=O,,O,[H-].[Na+],val
US04052362,NNC(=O)c1ccc(O)cc1.O=C(Cl)C=Cc1ccccc1>>O=C(C=Cc1ccccc1)NNC(=O)c1ccc(O)cc1,,O,,CC(=O)O,,val
US20140275172A1,COCOc1ccc2c(c1C=O)OCO2>>O=Cc1c(O)ccc2c1OCO2,,ClCCl,ClCCl,O=C(O)C(F)(F)F,,val
US20050261177A1,CC(C)(C)OC(=O)ON1CCC(O)CC1.CCCCI>>CCCCOC1CCN(OC(=O)OC(C)(C)C)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US20080234273A1,COC(=O)c1cc(OCc2ccccc2)cc(O[C@@H](C)COC(F)F)c1>>C[C@@H](COC(F)F)Oc1cc(OCc2ccccc2)cc(C(=O)O)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20150141406A1,CCC(CC)n1cc(-c2csc(C(=O)O)c2)c2c(=O)[nH]ccc21.CCN=C=NCCCN(C)C>>CCC(CC)n1cc(-c2csc(C(N)=O)c2)c2c(=O)[nH]ccc21,,CC(=O)N(C)C,O,Cl,,val
US20040116475A1,CCN(CC)CC.COc1ccc(-n2nc(C#N)cc2-c2ccc(CN)cc2)cc1.ClC(Cl)Cl.O>>COc1ccc(-n2nc(C#N)cc2-c2ccc(CNC(N)=O)cc2)cc1,,ClCCl,,,,val
US04364875,Cc1cc(Cl)c(S)cc1Cl.O=[N+]([O-])c1ccc(Cl)c(Cl)c1Oc1ccccc1>>Cc1cc(Cl)c(Sc2ccc([N+](=O)[O-])c(Oc3ccccc3)c2Cl)cc1Cl,,CS(C)=O,,[Na+].[OH-],,val
US20110183998A1,CC(=O)NC(C)CCc1ccc(OC(C)=O)cc1>>CC(=O)NC(C)CCc1ccc(O)cc1,,CO,,Cl,C[O-].[Na+],val
US20020147205A1,CCCC[Sn](CCCC)(CCCC)c1cc(C=O)co1.Fc1cccc(COc2ccc(Nc3ncnc4cnc(Cl)cc34)cc2)c1>>O=Cc1coc(-c2cc3c(Nc4ccc(OCc5cccc(F)c5)cc4)ncnc3cn2)c1,,C1COCCO1,,,,val
US06498275B1,CC(=O)Nc1ccc(S(=O)(=O)c2ccc([N+](=O)[O-])c(Cl)c2)cc1>>CC(=O)Nc1ccc(S(=O)(=O)c2ccc(N)c(Cl)c2)cc1,[Fe],CCO,,Cl,O,val
US20110311461A1,COc1cccc(NC(C(=O)O)c2csc3ccccc23)c1.O[C@H]1CN2CCC1CC2>>COc1cccc(NC(C(=O)O[C@H]2CN3CCC2CC3)c2csc3ccccc23)c1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20130267546A1,BrCc1ccccc1.OCCCCCCCCCBr>>BrCCCCCCCCCOCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20160198713A1,C#CCOc1ccccc1C1CC(c2csc(C3CCN(C(=O)OC(C)(C)C)CC3)n2)=NO1.Cl>>C#CCOc1ccccc1C1CC(c2csc(C3CC[NH2+]CC3)n2)=NO1.[Cl-],,C1COCCO1,,,,val
US20120028970A1,Cc1nc(SCc2cc(N3CCSCC3)cc(NC(=O)OC(C)(C)C)n2)oc1C.Fc1cccc(CCl)n1>>Cc1nc(SCc2cc(N3CCSCC3)cc(N(Cc3cccc(F)n3)C(=O)OC(C)(C)C)n2)oc1C,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US03966766,O=C1COCCOCC(=O)NCCOCCOCCN1>>C1COCCOCCNCCOCCOCCN1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060211734A1,CC1(C)CC(=O)CCN1Cc1ccccc1>>CC1(C)CC(O)CCN1Cc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150141453A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1c(CO)cccc1CO>>CC(C)(C)OC(=O)Nc1c(CO)cccc1CO,,CCO,,,,val
US20110034464A1,CCNS(=O)(=O)c1ccc(F)cc1CN.N#CC(C(N)=O)C1OC(=O)C(Cl)=C1Cl>>CCNS(=O)(=O)c1ccc(F)cc1Cn1cc(Cl)cc(C(N)=O)c1=N.Cl,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20050171109A1,BrCc1ccccc1Br.[C-]#N>>N#CCc1ccccc1Br,,CN(C)C=O,,O,,val
US05585394,CCNCC.CCOc1ccc2c(c1)n(C1CCCCC1)c(=O)n2S(=O)(=O)c1ccc(NC(=O)CCl)cc1OC.O=C(O)/C=C/C(=O)O>>CCOc1ccc2c(c1)n(C1CCCCC1)c(=O)n2S(=O)(=O)c1ccc(NC(=O)CN(CC)CC)cc1OC.O=C(O)/C=C/C(=O)O,,CC(C)=O,CCOCC,C1CCOC1,,val
US20050085476A1,COC(=O)Cc1n[nH]c(=O)c2c1CCCC2>>O=C(O)Cc1n[nH]c(=O)c2c1CCCC2,,CO,,[Na+].[OH-],,val
US04595677,CC(C)C[C@H](NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)N[C@@H](C)C(=O)OC(C)(C)C>>CC(C)C[C@H](NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)N[C@@H](C)C(=O)O,,O=C(O)C(F)(F)F,,,,val
US04874775,CS(=O)(=O)Cl.Fc1ccc(NCc2cccnc2)c(F)c1>>CS(=O)(=O)N(Cc1cccnc1)c1ccc(F)cc1F,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US05677305,Nc1cc(Cl)c(-n2ccc(=O)cc2)cc1N.O=C(O)C(=O)O>>O=c1ccn(-c2cc3[nH]c(=O)c(=O)[nH]c3cc2Cl)cc1,,Cl,,,,val
US06737547B1,CC(=O)OC(C)=O.ON=C1CCc2ccccc21>>CC(=O)NC1=CCc2ccccc21,,c1ccncc1,,,,val
US20160096827A1,C[Si](C)(C)CCOC(=O)ON1C(=O)CCC1=O.Cc1cc([N+](=O)[O-])ccc1C1=CCNCC1>>Cc1cc([N+](=O)[O-])ccc1C1=CCN(C(=O)OCC[Si](C)(C)C)CC1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20110288066A1,COC(=O)c1ccc(Br)cc1S(=O)(=O)C(C)C>>CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20130261178A1,CC(C)(C)OC(=O)NCCN.O=C(Cl)Oc1ccccc1>>CC(C)(C)OC(=O)NCCNC(=O)Oc1ccccc1,,ClCCl,,,,val
US20150133428A1,NC(=O)c1c(-c2ccc(F)c(Cl)c2)nn2c1CN(C(=O)NC1CNC1)CC2.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>NC(=O)c1c(-c2ccc(F)c(Cl)c2)nn2c1CN(C(=O)NC1CN(CC(F)(F)F)C1)CC2,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US05883102,NC1=NC2(CNC2)Nc2cccc(F)c21.O=C(Cl)c1cccs1>>NC1=NC2(CN(C(=O)c3cccs3)C2)Nc2cccc(F)c21,,ClCCl,,CCN(CC)CC,,val
US20090163508A1,Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.Fc1ccc(F)c(-c2ccnc(N3CCNCC3)n2)c1>>Cc1noc(NC(=O)N2CCN(c3nccc(-c4cc(F)ccc4F)n3)CC2)c1C,,C1CCOC1,CCCCCC,Cl,Cl,val
US20110269791A1,CC1(C)[C@H]2Cc3c(O)cccc3[C@]1(C)CCN2C(=O)[C@@H]1CC[C@@H](N)C1.O=S(=O)(Cl)c1ccccc1>>CC1(C)[C@H]2Cc3c(O)cccc3[C@]1(C)CCN2C(=O)[C@@H]1CC[C@@H](NS(=O)(=O)c2ccccc2)C1,,ClCCl,,CCN(CC)CC,,val
US20110117073A1,C=CC(=O)Cl.Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(N)cc3)n2)[nH]n1>>C=CC(=O)Nc1ccc(Sc2nc(Nc3cc(C)n[nH]3)cc(N3CCN(C)CC3)n2)cc1,,CCOC(C)=O,ClCCl,,,val
US20100216802A1,CC(C)(C)OC(=O)N1CCC(N)C1.CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)O)cc3OC)nc2N1C1CCCC1>>CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C(=O)OC(C)(C)C)C4)cc3OC)nc2N1C1CCCC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20150322056A1,CC(C)(C)OC(=O)[C@](C)(O)[C@H]1OCCN(c2ccn(COC(=O)C(C)(C)C)n2)C1=O>>CC(C)(C)OC(=O)[C@](C)(O)[C@H]1OCCN(c2cc[nH]n2)C1=O,,CO,O,C[O-].[Na+],,val
US20030050330A1,CSc1ccc(CC(=O)c2ccc(F)cc2)cc1.O=S([O-])OO>>CS(=O)(=O)c1ccc(CC(=O)c2ccc(F)cc2)cc1,,C1CCOC1,O,CO,,val
US20110112135A1,COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2cccc(Oc3cccc(-c4c(C(C)C)nc5c(Cl)cccn45)c3)c2)cc1>>CC(C)c1nc2c(Cl)cccn2c1-c1cccc(Oc2cccc(S(N)(=O)=O)c2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160194350A1,COC1O[C@H](COC(=O)c2ccccc2)C[C@@H]1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC1O[C@H](COC(=O)c2ccccc2)C[C@@H]1OS(=O)(=O)C(F)(F)F,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20080114006A1,CCNc1cc(Cl)ncc1CO>>CCNc1cc(Cl)ncc1C=O,O=[Mn]=O,ClCCl,,,,val
US20130237537A1,CCO.N#Cc1cncc2c1CCN(Cc1ccccc1)C2.O>>COC(=O)c1cncc2c1CCN(Cc1ccccc1)C2,,O,,[Na+].[OH-],,val
US04625048,CCOC(=O)C(C)Oc1ccc(Oc2ccc(F)cc2)cc1>>CC(CO)Oc1ccc(Oc2ccc(F)cc2)cc1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090325951A1,CN(C)Cc1cc2c([nH]c(=O)c3cccc(O)c32)s1.Cl>>CN(C)Cc1cc2c([nH]c(=O)c3cccc(O)c32)s1.Cl,,CO,,Br,,val
US20110098297A1,COC(OC)C(CNC(=O)c1cc2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O)c2[nH]1)SCc1ccccc1.COCC(C)O>>COCC(C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc2cc(C(=O)NCC(SCc3ccccc3)C(OC)OC)[nH]c12,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US04282365,COC(=O)c1ccc2c(c1)C(n1ccnc1)c1ccccc1CO2>>O=C(O)c1ccc2c(c1)C(n1ccnc1)c1ccccc1CO2,,C1CCOC1,CO,Cl,[K+].[OH-],val
US20100010060A1,O=C(Nc1cccc2c1C(=O)N(Cc1ccc(I)cc1)C2=O)c1ccc(Cl)s1>>O=C(Nc1cccc2c1C(=O)N(Cc1ccc(I)cc1)C2O)c1ccc(Cl)s1,,CO,ClCCl,Cl,[BH4-].[Na+],val
US20100041658A1,CCc1ccc(Oc2ccc(S(=O)(=O)NCCc3ccccn3)cc2F)c(OCc2ccccc2)c1>>CCc1ccc(Oc2ccc(S(=O)(=O)NCCc3ccccn3)cc2F)c(O)c1,,CCO,,C1CCOC1,,val
US20150284395A1,COC(=O)c1ccc2c(cnn2C(C)C)c1>>CC(C)n1ncc2cc(C(=O)O)ccc21,,CO,O,[Na+].[OH-],,val
US20140350019A1,CCOC(=O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2Cl)c1F>>O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2Cl)c1F,,C1CCOC1,,[Na+].[OH-],,val
US20070299056A1,C1COCCN1.O=C(O)c1ncc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cn1>>O=C(c1ncc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cn1)N1CCOCC1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US04611056,CC(=O)Oc1cc2c(c3ccccc13)Nc1ccccc1S2(=O)=O>>O=S1(=O)c2ccccc2Nc2c1cc(O)c1ccccc21,,CO,,CC(=O)O,[Na+].[OH-],val
US20060041128A1,Cc1noc2nc(C(N=[N+]=[N-])C(C)C)n(Cc3cccc(F)c3)c(=O)c12>>Cc1noc2nc(C(N)C(C)C)n(Cc3cccc(F)c3)c(=O)c12,,Cc1ccccc1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100048568A1,O=NN1CCOc2ccc(F)cc21>>NN1CCOc2ccc(F)cc21,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100168418A1,CNC(=O)c1cc(=O)n(CCN2CCC(N)CC2)c2cc(OC)ccc12.Cc1cccc(C=O)c1>>CNC(=O)c1cc(=O)n(CCN2CCC(NCc3cccc(C)c3)CC2)c2cc(OC)ccc12,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US04542132,BrCc1ccccc1.O=S1(=O)CCCN1CCc1ccncc1>>O=S1(=O)CCCN1CCC1=CCN(Cc2ccccc2)CC1,,CCO,,O,[BH4-].[Na+],val
US20050267095A1,CCOC(=O)N1CCN(CCCCl)CC1.N#CC1(c2ccc(OCCCN3CCCC3)cc2)CCOCC1>>CCOC(=O)N1CCN(CCCOc2ccc(C3(C#N)CCOCC3)cc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04968708,Nc1nc2ccccc2s1.O=CCCl>>c1ccc2c(c1)sc1nccn12,,CCCCO,,,,val
US20100240702A1,C#CC(=O)OCC.O=c1[nH]c2ccccc2n1Cc1cccc2ccccc12>>CCOC(=O)/C=C/n1c(=O)n(Cc2cccc3ccccc23)c2ccccc21,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,,,val
US20090048259A1,C[C@@H]1CNCCN1c1nnc(-c2ccccc2)c2ccccc12.O=C(Cl)c1ccccc1>>C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccccc2)c2ccccc12,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20040259883A1,CCOC(=O)CC(=O)C(F)(F)F.COc1ccc(N)c(OC)c1>>COc1cc(OC)c2nc(C(F)(F)F)cc(O)c2c1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20060173002A1,CC(C)(C)c1ccccc1Oc1ncccc1N.O=c1ccccn1C(=S)n1ccccc1=O>>CC(C)(C)c1ccccc1Oc1ncccc1N=C=S,,ClCCl,,,,val
US20050009846A1,CC[C@H](NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(O)C(C)C>>CC[C@H](N)C(O)C(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070185089A1,O=C(O)c1ccc(C(=O)C(F)(F)F)cc1.c1cc2c(cc1N1CCNCC1)CCN(C1CCC1)CC2>>O=C(c1ccc(C(=O)C(F)(F)F)cc1)N1CCN(c2ccc3c(c2)CCN(C2CCC2)CC3)CC1,,CN(C)C=O,,On1nnc2ccccc21,,val
US20080051399A1,C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)OC(C)(C)C)C[C@@H]3C)c21.Cl.ClCCl>>C[C@@H]1C[C@@H](O)c2ncnc(N3CCNC[C@@H]3C)c21.Cl.Cl,,ClCCl,,,,val
US20120245161A1,COC(=O)COc1ccc(CNC(=O)OC(C)(C)C)cc1-c1ccncc1>>COC(=O)COc1ccc(CNC(=O)OC(C)(C)C)cc1C1CCNCC1,O=[Pt]=O,CC(=O)O,CO,,,val
US20090239864A1,Cl.Cn1c(N2CCOCC2)nc(-c2ccncc2F)cc1=O.NCCc1ccc(F)cc1>>Cl.Cn1c(N2CCOCC2)nc(-c2ccncc2NCCc2ccc(F)cc2)cc1=O,,CO,,,,val
US20070072893A1,CC(C)(C)[Si](C)(C)OCCCCNc1c(N)cnc2ccccc12.CCOC(OCC)OCC>>CC(C)(C)[Si](C)(C)OCCCCn1cnc2cnc3ccccc3c21,,Cc1ccccc1,,,,val
US20090076049A1,ClCCl.O=S(Cl)Cl.OCC1CC1c1ccc(Cl)c(Cl)c1.c1ccc2[nH]nnc2c1>>ClCC1CC1c1ccc(Cl)c(Cl)c1.O=S(Cl)Cl.c1ccc2[nH]nnc2c1,,ClCCl,,,,val
US08927550B2,CCOC(=O)c1cccn2c(-c3ccc(F)cc3)ncc12>>O=C(O)c1cccn2c(-c3ccc(F)cc3)ncc12,,CO,O,[K+].[OH-],,val
US06350749B1,Cc1ccnc2c1C(=O)CC(c1c(Cl)cccc1Cl)C2.Cl.N=C(NN)NO>>Cc1ccnc2c1C(=NNC(=N)NO)CC(c1c(Cl)cccc1Cl)C2.Cl,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140371464A1,CC(=O)c1ccc(C2(F)CN(C(=O)OC(C)(C)C)C2)cc1.O=C(c1cc(Cl)cc(Cl)c1)C(F)(F)F>>CC(C)(C)OC(=O)N1CC(F)(c2ccc(C(=O)/C=C(/c3cc(Cl)cc(Cl)c3)C(F)(F)F)cc2)C1,,Cc1ccccc1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140005168A1,COc1ccc(Br)nc1N1CCC[C@H](NC(=O)OC(C)(C)C)C1.Cc1cncc(-c2cc3[nH]ncc3cn2)n1>>COc1ccc(-n2ncc3cnc(-c4cncc(C)n4)cc32)nc1N1CCC[C@H](NC(=O)OC(C)(C)C)C1,I[Cu]I,C1COCCO1,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US20150057265A1,C=C1C(=O)C=C(c2ccncc2[N+](=O)[O-])C[C@@H]1C>>C=C1[C@H](O)C=C(c2ccncc2[N+](=O)[O-])C[C@@H]1C,,CO,,[BH4-].[Na+],,val
US05420275,CCOC(=O)c1c(Cl)nc(-c2ccccc2)c(N)c1C(=O)OCC>>CCOC(=O)c1cnc(-c2ccccc2)c(N)c1C(=O)OCC,[Pd],CCOC(C)=O,,CCN(CC)CC,,val
US20150087646A1,C#Cc1ccc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)cc1.FC(F)(F)c1ccc(I)c(Cl)c1>>O=c1[nH]c(-c2c(F)cccc2Cl)nn1-c1ccc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CS(C)=O,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130116234A1,C1CCNC1.CCOC(=O)c1c(Cl)nc2ccc(Cl)cc2c1-c1ccccc1>>CCOC(=O)c1c(N2CCCC2)nc2ccc(Cl)cc2c1-c1ccccc1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US06756388B1,COc1ccc2cc(C3=CCCCC3)sc2c1>>COc1ccc2cc(C3CCCCC3)sc2c1,[Pd],CCOC(C)=O,,,,val
US20040063781A1,COC(=O)Cc1cc(Br)c(Oc2ccc(OC)c(C(C)C)c2)c(Br)c1.Cc1cccc(C(=O)Cl)c1>>COC(=O)Cc1cc(Br)c(Oc2cc(C(C)C)c(OC)cc2C(=O)c2cccc(C)c2)c(Br)c1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US05559105,CCCCc1ncc(C(=S)c2ccc(OC)cc2OCC(=O)OC(C)(C)C)n1C.COC(=O)C(Cc1ccc2c(c1)OCO2)=[N+]=[N-]>>CCCCc1ncc(/C(=C(\Cc2ccc3c(c2)OCO3)C(=O)O)c2ccc(OC)cc2OCC(=O)O)n1C,,CCOCC,,,,val
US06057369,CCOC(=O)CC(CCCCc1ccccc1)c1ccc(OC)c(OC)c1>>COc1ccc(C(CCCCc2ccccc2)CC(=O)O)cc1OC,,CCO,,Cl,[Na+].[OH-],val
US20110144105A1,CC(C)(C)OC(=O)Nc1cnc2[nH]c(C(=CC3CCCC3)c3ccc(S(C)(=O)=O)cc3)cc2c1>>CC(C)(C)OC(=O)Nc1cnc2[nH]c(C(CC3CCCC3)c3ccc(S(C)(=O)=O)cc3)cc2c1,[Pd],CO,,,,val
US20020103229A1,O=C(NCc1ccccc1)c1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1>>O=C(NCc1ccccc1)c1cccc(-c2n[nH]c3ccc(-c4ncn[nH]4)cc23)c1,,C1COCCO1,,Cl,[Na+].[OH-],val
US20120277208A1,CC(C)Oc1cc(Oc2ccc(C(N)=NO)nc2)cc(C(=O)Nc2ccn(C)n2)c1.O=C(Cl)C1CC1>>CC(C)Oc1cc(Oc2ccc(-c3noc(C4CC4)n3)nc2)cc(C(=O)Nc2ccn(C)n2)c1,,CCOC(C)=O,O,CCN(CC)CC,ClCCl,val
US20140030189A1,CC(C)(C)[Si](C)(C)Oc1ccc(C=O)cc1Br>>CC(C)(C)[Si](C)(C)Oc1ccc(CO)cc1Br,,CO,,,,val
US20160002169A1,O=C(O)[C@H]1C[C@@H](C(=O)O)C1.OCc1ccccc1>>O=C(O)[C@@H]1C[C@H](C(=O)OCc2ccccc2)C1,CN(C)c1ccncc1,CN(C)C=O,O,CCN=C=NCCCN(C)C,Cl,val
US06069157,N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1-c1cc(Br)no1>>N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)cc1-c1cc(Br)no1,,C1CCOC1,,CC(C)(C)ON=O,,val
US20080300275A1,CCOC(CN(CCc1ccccc1)C(=O)CCOCCc1ccc(Br)cc1)OCC>>O=CCN(CCc1ccccc1)C(=O)CCOCCc1ccc(Br)cc1,,C1COCCO1,,Cl,ClCCl,val
US20030065038A1,C#CCCl.NC1CCc2ccccc21>>C#CCNC1CCc2ccccc21.Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04818277,CCCS.NS(=O)(=O)c1ccccc1Cl>>CCCSc1ccccc1S(N)(=O)=O,,CN(C)C=O,,[K+].[OH-],,val
US20130217680A1,C=Cc1ccc2c(c1)CCOC2=O.O=C(OO)c1cccc(Cl)c1>>O=C1OCCc2cc(C3CO3)ccc21,,ClCCl,,,,val
US20070287739A1,Cc1nc(C(=O)O)nn1-c1ccc(F)cc1>>Cc1nc(CO)nn1-c1ccc(F)cc1,,C1CCOC1,,B,,val
US20080009530A1,CCCCOc1cc(CCS(N)(=O)=O)n(Cc2ccc(Cl)cc2Cl)n1.O=C(Cl)OCc1ccccc1>>CCCCOc1cc(CCS(=O)(=O)NC(=O)OCc2ccccc2)n(Cc2ccc(Cl)cc2Cl)n1,CN(C)c1ccncc1,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20040132748A1,BrBr.CCCCOc1nc(N)c2ncn(Cc3ccc(Cl)nc3)c2n1>>CCCCOc1nc(N)c2nc(Br)n(Cc3ccc(Cl)nc3)c2n1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US04806141,CCCCI.Cc1cc(O)cc(C)c1C=O>>CCCCOc1cc(C)c(C=O)c(C)c1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130251761A1,CC(C)(C)OC(=O)N1CCNCC1.CCc1nn2c(=O)cc(Cl)nc2s1>>CCc1nn2c(=O)cc(N3CCN(C(=O)OC(C)(C)C)CC3)nc2s1,,CC#N,,CCN(C(C)C)C(C)C,,val
US04584132,O=C(Cl)Cc1ccccc1.O=C(N[C@H]1CNC1=O)OCc1ccccc1>>O=C(Cc1ccccc1)N[C@H]1CNC1=O,[Pd],CCO,,CCN(CC)CC,CN(C)C=O,val
US20070117854A1,N#Cc1ccn(CO)c1.O=S(Cl)Cl>>N#Cc1ccn(CCl)c1,,ClC(Cl)Cl,,,,val
US20120122840A1,COc1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1nc(NC2CCCCC2)c2ncn(C3CCCCO3)c2n1>>COc1cc(C2=CCNCC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100048553A1,c1ccc(C2(N3CCC3)CCC3(CC2)OCCO3)cc1>>O=C1CCC(c2ccccc2)(N2CCC2)CC1,,CC(C)=O,,Cl,[Na+].[OH-],val
US20070129393A1,O=Cc1ccccc1O.O=[N+]([O-])c1cccc(S(=O)(=O)OC[C@@H]2CO2)c1>>O=Cc1ccccc1OC[C@@H]1CO1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20160184318A1,CC(C)(C)OC(=O)CBr.Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCNC[C@H]2C)n1>>Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCN(CC(=O)OC(C)(C)C)C[C@H]2C)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100298384A1,[N-]=[N+]=NC[C@H]1CN(c2ccc(-c3nc(CCl)co3)c(F)c2)C(=O)O1.c1c[nH]nn1>>[N-]=[N+]=NC[C@H]1CN(c2ccc(-c3nc(Cn4cncn4)co3)c(F)c2)C(=O)O1,,CCOC(C)=O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20160002224A1,CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@H]2[C@@H]1OC[C@H]2OCc1cc2nc(-c3ccc(C4(CO)CC4)cc3)ccc2[nH]1>>OCC1(c2ccc(-c3ccc4[nH]c(CO[C@@H]5CO[C@@H]6[C@H](O)CO[C@@H]65)cc4n3)cc2)CC1,,CCOC(C)=O,,Cl,,val
US20040198988A1,COC(=O)[C@@H]1Cc2ccccc2N1C(=O)[C@H](C)NC(=O)OC(C)(C)C>>COC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@H](C)NC(=O)OC(C)(C)C,[Rh],CO,,,,val
US20060084654A1,CNC.Cc1ccc(S(=O)(=O)OC[C@@H]2C[C@H](c3nc(-c4cccc(OCc5ccccc5)c4)c4c(N)nccn34)C2)cc1>>CN(C)C[C@@H]1C[C@H](c2nc(-c3cccc(OCc4ccccc4)c3)c3c(N)nccn23)C1,,C1CCOC1,,,,val
US20030119899A1,BrBr.O=C1C=CC(OCc2ccccc2)O1>>CCOC1OC(=O)C=C1Br,,ClC(Cl)(Cl)Cl,,,,val
US20090069287A1,C=C(C)c1cccc(C2(NC(=O)OC(C)(C)C)CCN(Cc3ccccc3)C2)c1>>CC(C)c1cccc(C2(NC(=O)OC(C)(C)C)CCNC2)c1,[Pd],,,[H][H],,val
US20160060197A1,CC(c1cccc(C(C)(O)C2CC2)c1OCc1ccccc1)C1CC1>>CC(c1cccc(C(C)(O)C2CC2)c1O)C1CC1,[Pd],CCO,,,,val
US20070037806A1,O=C(Cl)c1ccc(-c2ccccc2)cc1.O=C(O)C[C@H]1C[C@@H](O)CN1>>O=C(O)C[C@@H]1C[C@@H](O)CN1C(=O)c1ccc(-c2ccccc2)cc1,,C1CCOC1,O,CCN(CC)CC,Cl,val
US05162325,CCCCC(=N)OCC.CCOC(=O)Cl>>CCCCC(=NC(=O)OCC)OCC,,ClCCl,,CCN(CC)CC,,val
US04215220,ClCC1CO1.Nc1ccc(Cl)cc1Cl>>OC(CCl)CNc1ccc(Cl)cc1Cl,,CCO,,Cl,,val
US20080312192A1,CC(C)(C)[Si](C)(C)Oc1ccc(Nc2cc(Oc3ccc([N+](=O)[O-])cc3)ncn2)cc1>>CC(C)(C)[Si](C)(C)Oc1ccc(Nc2cc(Oc3ccc(N)cc3)ncn2)cc1,[Ni],C1CCOC1,CCO,,,val
US06380218B1,CCN=C=N.COc1cccc(Oc2ncccc2C(=O)O)c1.Cl.On1nnc2ccccc21>>COc1cccc(Oc2ncccc2C(=O)NCc2ccccc2Cl)c1,,CN(C)C=O,O,,,val
US20040039038A1,CCOc1ccc(C(=O)N(C)Cc2cccc(-c3ccc(C=C4SC(=O)NC4=O)cc3)c2)cc1OCC>>CCOc1ccc(C(=O)N(C)Cc2cccc(-c3ccc(CC4SC(=O)NC4=O)cc3)c2)cc1OCC,,CO,,,,val
US20090312381A1,CCOC(=O)Cn1cc(-c2ccccc2)n(C2CC2)c1=O>>O=C(O)Cn1cc(-c2ccccc2)n(C2CC2)c1=O,,CO,,[K+].[OH-],,val
US20060058352A1,CN(CCCl)CCCl.COc1ccc(CC#N)cc1>>COc1ccc(C2(C#N)CCN(C)CC2)cc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US05218000,COc1ccccc1CC(=O)O.NCCCNCCCCNCCCN>>COc1ccccc1CC(=O)NCCCNCCCCNCCCN,,COCCOC,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100113512A1,CC(C)CCON=O.O=C1CCc2cc(F)c(F)cc21>>NC1Cc2cc(F)c(F)cc2C1,,CO,,Cl,O,val
US04649142,COc1ccc(-c2cc(=O)n(C)c(=O)n2C)cc1OC.O=C1CCC(=O)N1Cl>>COc1ccc(-c2c(Cl)c(=O)n(C)c(=O)n2C)cc1OC,,CC(=O)O,,,,val
US20160039772A1,Cn1c(=O)n(CCCO[Si](C)(C)C(C)(C)C)c(=O)c2cc(OC(F)(F)F)ccc21.O=Cc1ccccc1>>Cn1c(=O)n(CCCO[Si](C)(C)C(C)(C)C)c(=O)c2c(C(O)c3ccccc3)c(OC(F)(F)F)ccc21,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US04627872,COCCCN.Nc1nc(Cl)nc(Cl)c1Cl>>COCCCNc1nc(N)c(Cl)c(Cl)n1,,C1CCOC1,,O,,val
US04424389,COc1c(C)c(C)c(OC)c(CC[C@](C)(O)C=O)c1C>>COc1c(C)c(C)c(OC)c(CC[C@](C)(O)CO)c1C,,CCO,,O,[BH4-].[Na+],val
US20080004309A1,CCOC(=O)c1nc(Br)c2c(c1O)c(C#N)c(-c1ccc(F)cc1)n2-c1ccccc1.C[Sn](C)(C)C>>CCOC(=O)c1nc(C)c2c(c1O)c(C#N)c(-c1ccc(F)cc1)n2-c1ccccc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,,,val
US20080300348A1,CC(C)(Br)C(=O)Br.O.O=C1CCC(=O)N1O>>CC(C)(Br)C(=O)[O-].O=C1CCC(=O)N1O,,ClCCl,,CCN(CC)CC,,val
US05591884,COC(=O)[C@H]1C=C(O)c2cc(OC)c(OC)c3c2[C@@H]1C[C@H](c1ccccc1)C3>>COC(=O)[C@@H]1CCc2cc(OC)c(OC)c3c2[C@@H]1C[C@H](c1ccccc1)C3,[Pd],CCOC(C)=O,CO,Cl,[H][H],val
US20160263093A1,C=C1CCC(C(C)(C)C)CC1.CCOC(=O)C1CCN(Cc2ccc3cc(OS(=O)(=O)C(F)(F)F)ccc3c2)CC1>>CCOC(=O)C1CCN(Cc2ccc3cc(C=C4CCC(C(C)(C)C)CC4)ccc3c2)CC1,,CN1CCCC1=O,,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[K+].[K+],val
US20110118245A1,CC(C)(C)c1cc(NC(=O)Nc2cc(O)ccc2F)no1.COc1cc2ncnc(Cl)c2cc1OC>>COc1cc2ncnc(Oc3ccc(F)c(NC(=O)Nc4cc(C(C)(C)C)on4)c3)c2cc1OC,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110172193A1,CCI.COc1c(N2CCCC(=C(F)CNC(=O)OC(C)(C)C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12>>CCOC(=O)c1cn(C2CC2)c2c(OC)c(N3CCCC(=C(F)CNC(=O)OC(C)(C)C)C3)c(F)cc2c1=O,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040102437A1,Nc1ccncc1.O=C=NC1CCCCC1>>O=C(Nc1ccncc1)NC1CCCCC1,,Cc1ccccc1,,,,val
US05708123,O=[N+]([O-])c1ccccc1NCCOCCOCCNc1ccccc1[N+](=O)[O-]>>Nc1ccccc1NCCOCCOCCNc1ccccc1N,,Cl,,Cl[Sn]Cl,,val
US20030007927A1,CC(C)(C)OC(=O)CCCBr.COC(=O)CCc1c(O)cccc1OCCCCCO>>COC(=O)CCc1c(OCCCCCO)cccc1OCCCC(=O)OC(C)(C)C,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080269193A1,Cc1cn(-c2cc(F)c(C(N)=O)c(N[C@@H]3CC[C@@H](OC(=O)CNC(=O)OC(C)(C)C)CC3)c2)c2c1C(=O)CC(C)(C)C2>>Cc1cn(-c2cc(F)c(C(N)=O)c(N[C@@H]3CC[C@@H](OC(=O)CN)CC3)c2)c2c1C(=O)CC(C)(C)C2,,C1COCCO1,,Cl,,val
US20060052396A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCNS(=O)(=O)c1ccc(Br)cc1OC(F)(F)F>>CC(C)(C)OC(=O)NCCN(C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Br)cc1OC(F)(F)F,CN(C)c1ccncc1,C1CCOC1,,,,val
US20120225866A1,CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(CCCO)ccc21.O=c1c2ccccc2ccn1CCNS(=O)(=O)c1ccccc1[N+](=O)[O-]>>CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(CCCN(CCn3ccc4ccccc4c3=O)S(=O)(=O)c3ccccc3[N+](=O)[O-])ccc21,,Cc1ccccc1,O,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20020115674A1,CCN=C=O.O=C(NOCc1ccccc1)c1cc(F)c(Cl)nc1Cl>>CCn1c(=O)n(OCc2ccccc2)c(=O)c2cc(F)c(Cl)nc21,,CC(=O)N(C)C,,[H-].[Na+],,val
US20140179743A1,CC(C)(C)OC(=O)NCCCBr.CCOc1ccc(/C=C2\SC(=O)NC2=O)cc1>>CCOc1ccc(/C=C2\SC(=O)N(CCCNC(=O)OC(C)(C)C)C2=O)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140171422A1,CO[C@@H]1C[C@@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)OC(C)(C)C)C1>>CO[C@@H]1C[C@@H](CO)N(C(=O)OC(C)(C)C)C1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160130268A1,CCN(CC)CCCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCc3cccc(NC(=O)OC(C)(C)C)c3)c2n1>>CCN(CC)CCCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCc3cccc(N)c3)c2n1,,ClCCl,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],,val
US20150307492A1,O=S(=O)(c1ccccc1)n1cc(I)c2cc(Br)cnc21.OB(O)c1ccccc1>>O=S(=O)(c1ccccc1)n1cc(-c2ccccc2)c2cc(Br)cnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US20100273764A1,COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(C(C)c4ccc(S(C)(=O)=O)cc4)cnc3Nc3ccc(OC)nc3)n2)cc1>>COc1ccc(Nc2ncc(C(C)c3ccc(S(C)(=O)=O)cc3)cc2-c2nc(C)nc(N)n2)cn1,,O=C(O)C(F)(F)F,,,,val
US20150152112A1,Nc1cc(-n2cccn2)ccc1[N+](=O)[O-]>>Nc1ccc(-n2cccn2)cc1N,[Fe],O,,CCO,[Cl-].[NH4+],val
US20120142727A1,BrBr.COC(=O)c1ccc2ccnc(O)c2c1>>COC(=O)c1ccc2c(Br)cnc(O)c2c1,,O,,CC(=O)O,,val
US20140356322A1,COCOc1ccc2c(c1)C[C@@H](CCCCOCCOCCOCCOCc1ccccc1)[C@H]1[C@@H]3CC[C@H](OCOC)[C@@]3(C)CC[C@H]21>>COCOc1ccc2c(c1)C[C@@H](CCCCOCCOCCOCCO)[C@H]1[C@@H]3CC[C@H](OCOC)[C@@]3(C)CC[C@H]21,[Pd],CCO,,,,val
US20120165318A1,COC[C@H]1CCCN1c1nc2cc(C(=O)OC)ccc2nc1-c1ccccc1>>COC[C@H]1CCCN1c1nc2cc(C(=O)O)ccc2nc1-c1ccccc1,,CO,O,[Na+].[OH-],,val
US06245761B1,CNC.Fc1ccc(Br)cc1CBr>>CN(C)Cc1cc(Br)ccc1F,,CO,,,,val
US20140206663A1,C[C@@H]1C(=O)NN=C2COc3ccc(NC4(C)CN(C(c5ccccc5)c5ccccc5)C4)cc3N21>>C[C@@H]1C(=O)NN=C2COc3ccc(NC4(C)CNC4)cc3N21,,CO,,Cl,,val
US05721234,BrBr.CC(=O)Nc1cccc2c1CC(N=[N+]=[N-])CC2>>CC(=O)Nc1ccc(Br)c2c1CC(N=[N+]=[N-])CC2,,CC(=O)O,,,,val
US20160130299A1,CCCN(C(=O)[C@@H](N)C(CC)CC)[C@H](C[C@@H](O)c1nc(C(=O)OC)cs1)C(C)C.CN1CCCC[C@@H]1C(=O)Oc1c(F)c(F)c(F)c(F)c1F>>CCCN(C(=O)[C@@H](NC(=O)[C@H]1CCCCN1C)C(CC)CC)[C@H](C[C@@H](O)c1nc(C(=O)OC)cs1)C(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20130096133A1,C1CNCCN1.ClCc1ccc(OCc2ccccc2)cc1>>c1ccc(COc2ccc(CN3CCNCC3)cc2)cc1,,C1CCOC1,,,,val
US05238832,C#CCCCCCCC.CC(C)(C)[Si](C)(C)OCc1ccc(CI)cc1>>CCCCCCCC#CCc1ccc(CO[Si](C)(C)C(C)(C)C)cc1,,C1CCOC1,CCOCC,O,[Li]CCCC,val
US20140256719A1,Clc1nc(Cl)c2c(-c3ccccc3)ccn2n1.NCc1ccccc1>>Clc1nc(NCc2ccccc2)c2c(-c3ccccc3)ccn2n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20140038919A1,COc1ccc(-c2nn3ccc(Br)cc3c2/C(N)=N/O)cc1.O=C(n1ccnc1)n1ccnc1>>COc1ccc(-c2nn3ccc(Br)cc3c2-c2noc(=O)[nH]2)cc1,,C1COCCO1,Cl,C1CCC2=NCCCN2CC1,,val
US20080207590A1,O=c1ccc2nc3ccccc3ccc-2c1>>Oc1ccc2c(c1)C=Cc1ccccc1N2,,ClC(Cl)Cl,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US04820705,COC(=O)CCC(=O)c1ccc2c(c1)CC(N)C2.COc1ccccc1S(=O)(=O)Br>>COC(=O)CCC(=O)c1ccc2c(c1)CC(NS(=O)(=O)c1ccccc1OC)C2,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US20040028936A1,CCN(CC)CC.O=C(O)CCCCCCCCCCC(=O)O.On1nnc2ccccc21>>NC(=O)CCCCCCCCCCC(N)=O,,ClCCl,,CN(C)C=O,Cl,val
US20130150343A1,CN1CCC[C@H]1C(=O)O.Cc1cc(F)cnc1NN>>Cc1cc(F)cnc1NNC(=O)[C@@H]1CCCN1C,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US20080070928A1,CC(C)(C)OC(=O)Nc1ccc(O)c(F)c1.CCS(=O)(=O)c1ccc(Cl)cn1>>CCS(=O)(=O)c1ccc(Oc2ccc(N)cc2F)cn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06090836,CCCc1cc(OC)c(C(=O)c2ccccc2)cc1OC>>CCCc1cc(O)c(C(=O)c2ccccc2)cc1O,,ClCCl,,BrB(Br)Br,O,val
US20150274704A1,Cc1cnc(Nc2cnn(C)c2)nc1N(C)C1CCC2(CCNCC2)CC1.N#CCC(=O)O>>Cc1cnc(Nc2cnn(C)c2)nc1N(C)C1CCC2(CC1)CCN(C(=O)CC#N)CC2,,CN(C)C=O,ClCCl,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060116512A1,COc1ccc2nccc([C@@H]3CN(CCCN)C(=O)O3)c2c1.O=Cc1ccc2nsnc2c1>>COc1ccc2nccc([C@@H]3CN(CCCNCc4ccc5nsnc5c4)C(=O)O3)c2c1,,CCOC(C)=O,ClCCl,CO,[BH4-].[Na+],val
US20080090863A1,Cc1c[n+]([O-])c(N[C@@H]2CC[C@H](NC(=O)c3ccc(F)c(Cl)c3)CC2)cc1[N+](=O)[O-]>>Cc1cnc(N[C@@H]2CC[C@H](NC(=O)c3ccc(F)c(Cl)c3)CC2)cc1N,[Fe],CC(=O)O,,,,val
US20070185075A1,C=O.CC(C)(C)CCNc1cc(N[C@@H]2CCNC2)ncn1>>CN1CC[C@@H](Nc2cc(NCCC(C)(C)C)ncn2)C1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060293308A1,CCCCCCS(=O)(=O)Cl.Nc1ccc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)cn1>>CCCCCCS(=O)(=O)Nc1ccc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)cn1,,CCOC(C)=O,c1ccncc1,,,val
US20090111791A1,CC(C)(C)OC(=O)N1CCC(O)CC1.CSc1ccc(F)cc1>>CSc1ccccc1OC1CCN(C(=O)OC(C)(C)C)CC1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US06359138B1,CS(=O)(=O)Cl.Nc1ccc2c(c1)CC(CBr)O2>>CS(=O)(=O)Nc1ccc2c(c1)CC(CBr)O2,,ClCCl,,CCN(CC)CC,,val
US20130310384A1,CCC(O)c1ccc(F)cc1.COC(=O)c1ccc(CNS(=O)(=O)c2ccc(Cl)cc2)cc1>>CCC(c1ccc(F)cc1)N(Cc1ccc(C(=O)OC)cc1)S(=O)(=O)c1ccc(Cl)cc1,,C1CCOC1,O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070173486A1,C1CCNCC1.O=C(Cl)N1CCC(OC(c2ccc(Cl)cc2)c2ccccc2Cl)CC1>>O=C(N1CCCCC1)N1CCC(OC(c2ccc(Cl)cc2)c2ccccc2Cl)CC1,,ClCCl,,CCN(CC)CC,,val
US20100273794A1,CC(C)Nc1cc(F)ccc1[N+](=O)[O-].O=C(n1ccnc1)n1ccnc1>>CC(C)n1c(=O)[nH]c2ccc(F)cc21,[Pd],CO,,C1CCOC1,,val
US20090111789A1,CCOC(=O)c1cnc(S(C)(=O)=O)nc1OCC.CNC>>CCOC(=O)c1cnc(N(C)C)nc1OCC,,CC#N,,,,val
US20160039808A1,CO.Oc1nc(Cl)nc2cnccc12>>COc1nc(O)c2ccncc2n1,,CO,,CO[Na],,val
US20140056849A1,CC(=O)Cl.CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F>>CCCS(=O)(=O)N(C(C)=O)c1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F,,C1COCCO1,,CCN(CC)CC,,val
US20030166644A1,CN(C(=O)Cl)c1ccccc1.OCCc1ccc(O)cc1>>CN(C(=O)Oc1ccc(CCO)cc1)c1ccccc1,,ClCCl,,,,val
US20090143444A1,CCCC[Sn](CCCC)(CCCC)c1ncccc1C.CN(Cc1cc(Br)n(S(=O)(=O)c2cccnc2)c1)C(=O)OC(C)(C)C>>Cc1cccnc1-c1cc(CN(C)C(=O)OC(C)(C)C)cn1S(=O)(=O)c1cccnc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20050096380A1,CCOC(=O)C(F)P(=O)(OCC)OCC.CCOc1cc2c(cc1C(=O)CC)C(C(C)(C)C)=CCC2(C)C>>CCOC(=O)/C(F)=C(/CC)c1cc2c(cc1OCC)C(C)(C)CC=C2C(C)(C)C,,C1CCOC1,,[Li]CCCC,,val
US20120022064A1,C1CCNC1.O=C1CCc2cc(OCCCCl)ccc2N1>>O=C1CCc2cc(OCCCN3CCCC3)ccc2N1,,CC(C)O,O,,,val
US20090264428A1,CC(C)(C)OC(=O)N[C@H]1CCCNC1.COc1c(OC)c(=O)c1=O>>COc1c(N2CCC[C@H](NC(=O)OC(C)(C)C)C2)c(=O)c1=O,,CC#N,,,,val
US20120252865A1,CCOC(=O)C(CC(C)=O)C(=O)c1cccc(OC)c1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)c1cc(C)sc1-c1cccc(OC)c1,,Cc1ccccc1,,CCCCCC,CCOC(C)=O,val
US05281593,ClCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1.N#CCCc1cccc2cc[nH]c12>>N#CCCc1cccc2ccn(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c12,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US06268391B1,O=C(O)C(=O)Cc1ccc(Br)cc1[N+](=O)[O-].OO>>O=C(O)Cc1ccc(Br)cc1[N+](=O)[O-],,O,,Cl,[Na+].[OH-],val
US20040127574A1,CCOC(=O)C(Cc1cccc(OCC(F)(F)F)c1)C(O)c1ccc(F)cc1>>O=C(O)C(Cc1cccc(OCC(F)(F)F)c1)C(O)c1ccc(F)cc1,,CO,,Cl,[Na+].[OH-],val
US05338739,CCN1CCCC1c1cccc(O)c1.CN=C=O>>CCN1CCCC1c1cccc(OC(=O)NC)c1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US06265411B1,COc1cc(C(N)=O)c([N+](=O)[O-])cc1OCCCN1CCOCC1>>COc1cc(C(N)=O)c(N)cc1OCCCN1CCOCC1,[Fe],CO,,Cl,,val
US20140073626A1,CC(C)(C)C(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Nc3ccc(C=O)cc3)nc12.N#CCc1nccs1>>CC(C)(C)C(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Nc3ccc(C=C(C#N)c4nccs4)cc3)nc12,,CCO,,C1CCNCC1,CC(=O)O,val
US20090203752A1,C1COCCN1.O=C=NC(=O)c1cccc(-c2noc(-c3ccccc3F)n2)c1>>O=C(NC(=O)N1CCOCC1)c1cccc(-c2noc(-c3ccccc3F)n2)c1,,ClCCl,,,,val
US20120264737A1,CC1(C)COCC(Br)C1=O.COC(=O)c1cc(C(=N)N)c(C)cc1C>>COC(=O)c1cc(-c2nc3c([nH]2)COCC3(C)C)c(C)cc1C,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US06197826B1,CC(C)(C)NO.O=Cc1cc([N+](=O)[O-])ccc1O>>CC(C)(C)[N+]([O-])=Cc1cc([N+](=O)[O-])ccc1O,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050245595A1,[N-]=[N+]=NC(CF)Cc1ccccc1>>NC(CF)Cc1ccccc1,[Pd],CO,,,,val
US07354932B2,C[Si](C)(C)N=C=O.NCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21>>NC(=O)NCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21,,CC(C)O,,,,val
US04257805,CN(C=O)c1ccc(F)c(Cl)c1>>CNc1ccc(F)c(Cl)c1,,O,,O=S(=O)(O)O,,val
US05393891,CCC(=O)c1ccc(-c2ccccc2F)cc1.O=C1Nc2ccc(CCNC(=O)C(F)(F)F)cc2C1=O>>Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(CCN)cc2c1C(=O)O,,CCO,O,[K+].[OH-],,val
US20010051620A1,CC#N.COC(=O)c1cc2ccc(OC)cc2cc1/N=C/N(C)C>>COc1ccc2cc3c(=O)c(C#N)c[nH]c3cc2c1,,C1CCOC1,,CC(=O)O,[Li]CCCC,val
US07935726B1,C[Si](C)(C)CCOCCl.Clc1[nH]cnc2ncnc1-2>>C[Si](C)(C)CCOCN1CNC(Cl)=C2N=CN=C21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110015181A1,CC(C)(C)O.O=C(O)c1cc(OCc2ccccc2)cc(COC2CCCCO2)n1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)Nc1cc(OCc2ccccc2)cc(COC2CCCCO2)n1,,C1COCCO1,O,CCN(CC)CC,,val
US20160046652A1,Cc1ccc(C)c(B(O)O)c1.Cc1ccnc(Br)c1>>Cc1ccnc(-c2cc(C)ccc2C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20090186879A1,COC(=O)CC(O)CNc1c([N+](=O)[O-])cccc1[N+](=O)[O-]>>COC(=O)CC(O)CNc1c(N)cccc1N,[Pd],C1CCOC1,,,,val
US04764617,O=C(Cc1ccc2ccccc2n1)NC(CCN1CCCCC1)c1ccccc1.O=C(O)/C=C/C(=O)O>>O=C(Cc1ccc2ccccc2n1)NC(CCN1CCCCC1)c1ccccc1.O=C(O)/C=C/C(=O)O,,CC(C)=O,CCO,,,val
US20140031338A1,C1COCCO1.CC(=O)c1cccc(C(F)(F)F)c1Br.O=[Se]=O>>COC(=O)C(O)c1cccc(C(F)(F)F)c1Br,,O,,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US20070015813A1,COC(=O)c1cccc2[nH]cc(I)c12.Cc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)c1cccc2c1c(I)cn2S(=O)(=O)c1ccc(C)cc1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20050148602A1,CC(C)(C)OC(=O)CN1CCN2C(=O)N(c3cc(Cl)cc(Cl)c3)C(=O)C2(Cc2ccc(Br)cc2)C1>>O=C(O)CN1CCN2C(=O)N(c3cc(Cl)cc(Cl)c3)C(=O)C2(Cc2ccc(Br)cc2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090176847A1,Cl.N#CC1CCCN1C(=O)CNC1CC2CC(O)(C3CCCCC3)CC2C1>>Cl.N#CC1CCCN1C(=O)CNC1CC2CC(O)(C3CCCCC3)CC2C1,,CCOCC,,,,val
US20120214803A1,Nc1cccc2cccnc12.O=[N+]([O-])c1ccc(F)cc1S(=O)(=O)Cl>>O=[N+]([O-])c1ccc(F)cc1S(=O)(=O)Nc1cccc2cccnc12,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20140031355A1,CC(=O)OC(C)C#Cc1ccccc1/C=N\O.O=C1CCC(=O)N1Br>>CC(=O)OC(C)c1c(Br)c2ccccc2c[n+]1[O-],,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20110190489A1,Cn1cc(-c2cc3nc(NNC(=O)OC(C)(C)C)cnc3n2COCC[Si](C)(C)C)cn1>>Cn1cc(-c2cc3nc(NN)cnc3n2COCC[Si](C)(C)C)cn1,,CCOC(C)=O,,C1COCCO1,Cl,val
US05378703,COCCCCN1CC(O)c2cc(S(=O)(=O)NC(C)(C)C)sc2S1(=O)=O>>COCCCCN1CC(=O)c2cc(S(=O)(=O)NC(C)(C)C)sc2S1(=O)=O,,CC(C)=O,,O=S(=O)(O)O,O=[Cr](=O)=O,val
US20070015748A1,CN1CCN(c2ccc(N)cc2)CC1.Cc1cc(NC(=O)c2ccccc2Sc2ccc3c(c2)NC(=O)/C3=C\O)n(C)n1>>CNC(=O)c1cccc(Sc2ccc3c(c2)NC(=O)C3=CNc2ccc(N3CCN(C)CC3)cc2)c1,,C1CCOC1,,,,val
US20160193218A1,CCN=C=O.COc1cc(OC)c2c(=O)[nH]c(-c3ncccc3NC3CCNCC3)nc2c1>>CCNC(=O)N1CCC(Nc2cccnc2-c2nc3cc(OC)cc(OC)c3c(=O)[nH]2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20080171743A1,C[C@H]1COCCN1c1cc(CS(=O)(=O)CCO)nc(-c2ccc(N)cc2)n1.O=C(Cl)Oc1ccccc1>>C[C@H]1COCCN1c1cc(CS(=O)(=O)CCO)nc(-c2ccc(NC(=O)Oc3ccccc3)cc2)n1,,C1COCCO1,,O,O=C([O-])O.[Na+],val
US20090018163A1,C=O.Cc1cc(COCC2(c3ccccc3)CCNCC2)c2ccccc2n1>>Cc1cc(COCC2(c3ccccc3)CCN(C)CC2)c2ccccc2n1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120270875A1,CCC(O)CC.Cc1nc(NCCCc2cccc(O)c2)nc(C)c1C(=O)N[C@@H](CNC(=O)c1cccs1)C(=O)O>>CCC(CC)OC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1c(C)nc(NCCCc2cccc(O)c2)nc1C,,C1COCCO1,CCOC(C)=O,O=S(Cl)Cl,,val
US20100137349A1,CC1(C)NC(=O)NC1=O.ClCCBr>>CC1(C)NC(=O)N(CCCl)C1=O,,CCO,,[K+].[OH-],,val
US20150210666A1,CC#CCOc1ccc(C[C@H](N)C(=O)OC)cc1.CCCCCCCC(F)(F)CCCCCC/C=C/[C@H](C(=O)N1C(=O)SC(c2ccccc2)(c2ccccc2)[C@@H]1C(C)C)[C@@](O)(CCOC)C(=O)[O-]>>CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCC(F)(F)CCCCCCC)[C@@](O)(CCOC)C(=O)OC(C)(C)C)C(=O)OC)cc1,,ClCCl,,,,val
US20140088079A1,C=CCOc1c([C@@H]2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)cc(Cc2ccc(OCC)cc2)c(Cl)c1OCC=C>>CCOc1ccc(Cc2cc([C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc4ccccc4)[C@H](OCc4ccccc4)[C@H]3OCc3ccccc3)c(O)c(O)c2Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,[BH4-].[Na+],[Cl-].[NH4+],val
US20150001472A1,Cc1cc(C(=O)NCCc2ccc(C(C)C)cc2)cc(C)c1F>>Cc1cc(C2=NCCc3ccc(C(C)C)cc32)cc(C)c1F,,Cc1ccccc1C,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US04933344,CC(=O)Nc1ccc(C(=O)CN2CCN(C)CC2)cc1>>CN1CCN(CC(=O)c2ccc(N)cc2)CC1,,CCO,,O,[Na+].[OH-],val
US20140031342A1,CC(C)(C(=O)O)c1ccc(OCc2ccc(C(F)(F)F)cc2)cc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(N=C=O)c1ccc(OCc2ccc(C(F)(F)F)cc2)cc1,,C1COCCO1,,CCN(CC)CC,,val
US20070219230A1,CN(C)C=O.Cc1cc2ccnc(N3CCc4ccccc4C3)c2n1Cc1cccc(F)c1.Cl>>Cc1c(C=O)c2ccnc(N3CCc4ccccc4C3)c2n1Cc1cccc(F)c1.Cl,,CN(C)C=O,,O=P(Cl)(Cl)Cl,O=C([O-])O.[Na+],val
US20040067981A1,C=Cc1cc(OC(=O)N(C)C)ccc1C(O)CCO.CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccncc1.ClCCl>>C=Cc1cc(OC(=O)N(C)C)ccc1C(O)CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,CN(C)c1ccncc1,ClCCl,,O,,val
US20030100556A1,CN1CCN(c2cccc3c2C[C@H](N)CO3)CC1.Cc1cncc(C(=O)O)c1>>Cc1cncc(C(=O)N[C@@H]2COc3cccc(N4CCN(C)CC4)c3C2)c1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20080009515A1,CCOC(=O)c1cnc(Cl)c2c(COc3cccc(-c4nnc(C)o4)c3)csc12.N>>CCOC(=O)c1cnc(N)c2c(COc3cccc(-c4nnc(C)o4)c3)csc12,,CC(C)O,,,,val
US20100317568A1,COC(=O)Cl.N[C@H](C(=O)O)c1ccccc1>>COC(=O)N[C@H](C(=O)O)c1ccccc1,,C1COCCO1,CCOC(C)=O,[Na+].[OH-],,val
US20030149107A1,BrP(Br)Br.OCc1ccc(O)cc1>>Oc1ccc(CBr)cc1,,C1CCOC1,,c1ccncc1,,val
US20090181957A1,CC(C)(C)[C@H](N)C(N)=O.CC(C)CCn1c(=O)[nH]c2ccccc21.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CC(C)CCn1c(=O)n(C(=O)N[C@H](C(N)=O)C(C)(C)C)c2ccccc21,,ClCCl,,CCN(CC)CC,,val
US20100267561A1,CO.Cc1cc(-c2ccc(C(F)(F)F)cc2)nn1-c1cnn(C)c(=O)c1-n1nc(-c2ccc(C(F)(F)F)cc2)cc1C>>COc1cnn(C)c(=O)c1-n1nc(-c2ccc(C(F)(F)F)cc2)cc1C,,CO,,C[O-].[Na+],,val
US20040157904A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cn1nc(C(C)(C)C)c(Br)c1N>>Cn1nc(C(C)(C)C)c(Br)c1NC(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20030134748A1,BrBr.Cc1csc(C)c1C(=O)O>>Cc1sc(Br)c(C)c1C(=O)O,,CC(=O)O,,O,,val
US06200976B1,CCCI.N#Cc1ccc(Cn2c(=O)[nH]c3cc([N+](=O)[O-])ccc3c2=O)cc1>>CCCn1c(=O)n(Cc2ccc(C#N)cc2)c(=O)c2ccc([N+](=O)[O-])cc21,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100305133A1,COC(=O)c1c(OC)c(-c2ccccc2)cc2ncc(-c3ccccc3)nc12>>O=C(O)c1c(O)c(-c2ccccc2)cc2ncc(-c3ccccc3)nc12,,ClCCl,,BrB(Br)Br,O,val
US20100016396A1,COC(=O)[C@H](C)Oc1cc(Oc2c(/C=N/O)c(C)nn2C)c(Cl)cc1Cl.N#CCBr>>COC(=O)[C@H](C)Oc1cc(Oc2c(/C=N/OCC#N)c(C)nn2C)c(Cl)cc1Cl,,CN(C)C=O,,O,[H-].[Na+],val
US20070037812A1,CCOC(=O)C=Cc1ccc(F)cc1C.COc1ccc(C)c(O)c1>>CCOC(=O)C=Cc1ccc(Oc2cc(OC)ccc2C)cc1C,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100256357A1,NS(=O)(=O)c1ccc(F)c(C(=O)O)c1>>NS(=O)(=O)c1ccc(F)c(CO)c1,,C1CCOC1,,B,CSC,val
US20140228361A1,COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCC2CN(C(=O)OC(C)(C)C)CC21>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCC2CNCC21,,CCOC(C)=O,,Cl,,val
US20130303492A1,CSC(SC)=C(C#N)C(N)=O.N#Cc1cccc(N)c1.NN>>N#Cc1cccc(Nc2n[nH]c(N)c2C(N)=O)c1,,CCO,,O,,val
US20040009983A1,CC(C)(C)c1ccc(-c2[nH]c3nccnc3c2CCCN)cc1.CS(=O)(=O)Cl>>CC(C)(C)c1ccc(-c2[nH]c3nccnc3c2CCCNS(C)(=O)=O)cc1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,O,val
US20100069368A1,COCC(=O)Cl.OCc1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1>>COCC(=O)OCc1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1,,ClCCl,,CCN(CC)CC,,val
US20040122050A1,NS(=O)(=O)O.O=Cc1cccc(C(=O)CC2CCC(c3cc(F)ccc3F)(S(=O)(=O)c3ccc(Cl)cc3)CC2)c1>>O=C(O)c1cccc(C(=O)CC2CCC(c3cc(F)ccc3F)(S(=O)(=O)c3ccc(Cl)cc3)CC2)c1,,ClCCl,O,[Na+].[O-]Cl,,val
US20100256188A1,CC(C)(C)OC(=O)Nc1cc(C#N)ccc1C(F)(F)F>>CC(C)(C)OC(=O)Nc1cc(CN)ccc1C(F)(F)F,[Ni],C1CCOC1,,,,val
US05334594,Fc1cccc(Oc2cccnc2)c1.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1cccc(Oc2cccc(F)c2)c1,,ClCCl,,O=S([O-])O.[Na+],,val
US04663343,C1CCNCC1.CN1C2CCCCC21>>CN[C@@H]1CCCC[C@H]1N1CCCCC1,,O,,[Cl-].[NH4+],,val
US03952031,CC(=O)OC(C)=O.CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](Br)C[C@]4(C)[C@H]3C(=O)C[C@]12C>>CC(=O)O[C@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@H](C(C)=O)[C@@]4(C)CC(=O)[C@@H]3[C@@]2(C)C[C@@H]1Br,,c1ccncc1,,O,,val
US20010018525A1,CCOC(=O)c1cc(Br)c(OCOC)c(Br)c1.CCOC(=O)c1cc(Br)c(OCOC)c(I)c1.Cc1cccc(B(O)O)c1.ClCCl>>CCOC(=O)c1cc(-c2cc(C)cc(C)c2)c(OCOC)c(-c2cc(C)cc(C)c2)c1,,C1COCCO1,O,CCOC(C)=O,,val
US20120157430A1,COc1c(C(C)NC(=O)OCc2ccccc2)cc(Cl)c(Cl)c1C1CN(C(=O)OC(C)(C)C)C1>>COc1c(C(C)N)cc(Cl)c(Cl)c1C1CN(C(=O)OC(C)(C)C)C1,[Pt],CO,Cl,O,[H][H],val
US20080015246A1,CCOC(=O)c1ccc(-c2ccc(OCCCO[Si](C)(C)C(C)(C)C)c(Br)c2)cc1.CCc1cc(B(O)O)ccc1N(CC)CC>>CCOC(=O)c1ccc(-c2ccc(OCCCO[Si](C)(C)C(C)(C)C)c(-c3ccc(N(CC)CC)c(CC)c3)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20120230951A1,O=P(Cl)(Cl)Cl.Oc1cnc2cc(Br)ccc2n1>>Clc1cnc2cc(Br)ccc2n1,,CN(C)C=O,,Cl,O=C([O-])O.[Na+],val
US20120022109A1,CCBr.CCc1ccccc1-c1ccc(C(=O)OC)cc1O>>CCOc1cc(C(=O)OC)ccc1-c1ccccc1CC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05739299,O=S(Cl)Cl.O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)O)c1>>O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)Cl)c1,,CN(C)C=O,,,,val
US09266853B2,CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCC(=O)CCCCCCC)[C@](C)(O)C(=O)O)C(=O)OC)cc1>>CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCC(=O)CCCCCCC)[C@](C)(O)C(=O)O)C(=O)O)cc1,,CO,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US20130172556A1,Cn1ccc2ccccc21.O=C(Cl)C(=O)Cl>>Cn1cc(C(=O)C(=O)Cl)c2ccccc21,,CCOCC,,,,val
US20080269210A1,CI.OC1(c2cc3nc(Cl)nc(N4CCOCC4)c3s2)COC1>>COC1(c2cc3nc(Cl)nc(N4CCOCC4)c3s2)COC1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20050233467A1,COc1cc(OC)c(C(=O)Cl)cc1F.COc1ccc(F)c(OC)c1>>O=C(c1cc(F)c(O)cc1O)c1cc(F)c(O)cc1O,,O=[N+]([O-])c1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20030087936A1,N#CNC(=Nc1ccncc1)NCC(O)c1ccccc1>>N#CN=C1NCC(c2ccccc2)N1c1ccncc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04348223,CCO.O=[N+]([O-])c1cccc(CCl)c1>>CCOCc1cccc([N+](=O)[O-])c1,,CCO,,C,C[O-].[Na+],val
US20070015798A1,CC(=O)OC(C)=O.CC(C)C[C@@H](N)C(=O)O>>CC(=O)N[C@H](CC(C)C)C(=O)O,,O,,Cl,[Na+].[OH-],val
US20090062358A1,CCOC(=O)C(C)(C)Oc1ccc(CCCc2nn(Cc3ccc(C(C)(C)C)cc3)c(=O)n2C)cc1>>Cn1c(CCCc2ccc(OC(C)(C)C(=O)O)cc2)nn(Cc2ccc(C(C)(C)C)cc2)c1=O,,CCO,,[Na+].[OH-],,val
US20080161313A1,II.OCCOc1ccc(Br)cc1>>Brc1ccc(OCCI)cc1,,Cc1ccccc1,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150307493A1,COc1cc(-c2cn(C)c(=O)c3c2ccn3S(=O)(=O)c2ccc(C)cc2)c2c(c1)N(CC(=O)OC(C)(C)C)C(=O)C(C(C)C)O2>>COc1cc(-c2cn(C)c(=O)c3[nH]ccc23)c2c(c1)N(CC(=O)O)C(=O)C(C(C)C)O2,,CCO,O,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20120083488A1,COc1ccc2c(c1)C(C)(C)C(=O)CC2.O=C1CCC(=O)N1Cl>>COc1cc2c(cc1Cl)CCC(=O)C2(C)C,,CC#N,,,,val
US20150152108A1,Clc1ccc2c(n1)N[C@H]1CCN2C1.Nc1ccccc1CCC(F)(F)F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(Nc1ccccc1CCC(F)(F)F)N1c2nc(Cl)ccc2N2CC[C@H]1C2,,C1CCOC1,ClCCl,CO,,val
US20070213333A1,O=Cc1ccc(OCC2CCCCC2)c(Br)c1.OB(O)c1ccc2ccccc2c1>>O=Cc1ccc(OCC2CCCCC2)c(-c2ccc3ccccc3c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20090005519A1,C1=COCCC1.OCCCCCCBr>>BrCCCCCCOC1CCCCO1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US07211119B2,COc1c(C)cc(N2CCOC2=O)cc1N1CCOC1=O>>COc1c(C)cc(NCCO)cc1NCCO,,O,,Cl,[K+].[OH-],val
US20050113436A1,COc1ccc2c(c1)c1c(n2Cc2ccc(C(C)(C)C)cc2)COC(=O)C1=O>>CC(C)(C)c1ccc(Cn2c3c(c4cc(O)ccc42)C(=O)C(=O)OC3)cc1,,ClCCl,,BrB(Br)Br,,val
US05006535,CCOC(=O)c1cnc2c(OC)cccc2c1Cl.COc1cscc1N>>CCOC(=O)c1cnc2c(OC)cccc2c1Nc1cscc1OC,,C1COCCO1,,,,val
US06008230,CNCCOC.O=Cc1ccnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc12>>COCCN(C)Cc1ccnc2c(NC(=O)c3c(Cl)cccc3Cl)cccc12,,CC(=O)O,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US07932274B2,C[C@@H]1C[C@H]1C(=O)Nc1snc(Br)c1Br.Cn1cc2cc(B3OC(C)(C)C(C)(C)O3)ccc2n1>>C[C@@H]1C[C@H]1C(=O)Nc1snc(-c2ccc3nn(C)cc3c2)c1Br,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20160176857A1,COc1ccc(Nc2n[nH]c(N)c2C(N)=O)cc1.Cc1cc(C=O)cc(C)c1O>>COc1ccc(Nc2n[nH]c(NCc3cc(C)c(O)c(C)c3)c2C(N)=O)cc1,C1CCNCC1,CCO,,O,[BH4-].[Na+],val
US06432993B1,CN(C(=O)OC(C)(C)C)c1cc(Oc2ccc(Cc3ccccc3)cc2)ccc1N.O=C(O)COc1ccc(CC2SC(=O)NC2=O)cc1>>CN(C(=O)OC(C)(C)C)c1cc(Oc2ccc(Cc3ccccc3)cc2)ccc1NC(=O)COc1ccc(CC2SC(=O)NC2=O)cc1,,C1CCOC1,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20020049220A1,C[Si](C)(C)CCOCn1cc(Br)nc1-c1ccc(F)cc1>>Fc1ccc(-c2nc(Br)c[nH]2)cc1,,CCO,,Cl,O,val
US04937268,COc1ccc(O)cc1.OCCCBr>>COc1ccc(OCCCO)cc1,,CS(C)=O,,Cl,[Na+].[OH-],val
US20040236109A1,CC(=O)C1(C)CC=C(C(=O)N2c3ccccc3C(C)CC2(C)C)C=C1N.O=C(Cl)c1ccco1>>CC(=O)C1(C)CCC(C(=O)C2=C(C)c3ccccc3NC2(C)C)C=C1NC(=O)c1ccco1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20160009666A1,CC(C)(C)NS(=O)(=O)c1ccc(C=O)cc1.Nc1nc(Nc2cc(Cl)cc(Cl)c2)n[nH]1>>CC(C)(C)NS(=O)(=O)c1ccc(CNc2nc(Nc3cc(Cl)cc(Cl)c3)n[nH]2)cc1,,CO,,CC(=O)O,Cl,val
US20080287517A1,Cc1c(C(=O)Nc2ccc(F)cn2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(O)cc1.O=S(=O)(Cl)CCC(F)(F)F>>Cc1c(C(=O)Nc2ccc(F)cn2)nn(-c2ccc(Cl)cc2Cl)c1C1(OS(=O)(=O)CCC(F)(F)F)C=CC=CC1,,ClCCl,,O,,val
US20100280092A1,CCO.O=C(O)CCc1c[nH]c2ccccc12>>CCOC(=O)CCc1c[nH]c2ccccc12,,O=S(=O)(O)O,,,,val
US20150291573A1,FC(F)(F)c1cccc(S)c1.O=S(=O)([O-])CC1CCOC(c2ccc(Br)cc2)C1>>FC(F)(F)c1cccc(SC2CCOC(c3ccc(Br)cc3)C2)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20150005279A1,BrCc1ccccc1.Cc1ccccc1C(=O)N[C@@H]1CCCNC1>>Cc1ccccc1C(=O)N[C@@H]1CCCN(Cc2ccccc2)C1,,ClCCl,,,,val
US20130109682A1,O=C1C[C@H](c2ccncc2[N+](=O)[O-])O[C@@H]2CCCC[C@]12O>>O=[N+]([O-])c1cnccc1[C@H]1C[C@@H](O)[C@@]2(O)CCCC[C@H]2O1,,CO,,[BH4-].[Na+],,val
US20130310395A1,Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(Br)c1>>Cn1cc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)cn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20140163012A1,CC(C)(C)OC(=O)N1CCc2oc3cc(-n4ccc(-c5ccc(C(F)(F)F)nn5)cc4=O)ccc3c2C1>>O=c1cc(-c2ccc(C(F)(F)F)nn2)ccn1-c1ccc2c3c(oc2c1)CCNC3,,CCOCC,CO,Cl,,val
US20060217380A1,COC(=O)c1cc(Cl)cn(C)c1=O>>Cn1cc(Cl)cc(C(=O)O)c1=O,,CO,,[Na+].[OH-],,val
US20080318957A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H](CC1CCNCC1)C(=O)O>>CC(C)(C)OC(=O)N[C@@H](CC1CCN(C(=O)OC(C)(C)C)CC1)C(=O)O,,ClCCl,,,,val
US04727078,COC(=O)c1cccc(OCC=C(c2ccccc2)c2cccnc2)c1>>O=C(O)c1cccc(OCC=C(c2ccccc2)c2cccnc2)c1,,CO,O,Cl,[Na+].[OH-],val
US05210211,CCCCc1nc(-n2cccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1>>CCCCc1nc(-n2cccc2)cn1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,CCOCC,Cc1ccccc1,,,val
US20110034452A1,CCc1c(Cl)nnc(Cl)c1C.NN>>CCc1c(Cl)nnc(NN)c1C,,C1COCCO1,,O,,val
US20150232463A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc(C)c(-c2ccc(Oc3ccccc3)cc2)c1N1CCC(C)(C)CC1>>Cc1nc(C)c([C@H](OC(C)(C)C)C(=O)O)c(N2CCC(C)(C)CC2)c1-c1ccc(Oc2ccccc2)cc1,,CCO,O,[Li+].[OH-],,val
US20140093505A1,CCOC(=O)c1cnc2ccc(Cl)nc2c1Cl.Nc1cccc(C(F)(F)F)c1>>CCOC(=O)c1cnc2ccc(Cl)nc2c1Nc1cccc(C(F)(F)F)c1,,CC(C)(C)O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20160007598A1,CCC1=C(C)[C@](O)(/C=C/C(C)=C\C(=O)OC)C(C)(C)CC1=O>>CCC1=C(C)[C@](O)(/C=C/C(C)=C\C(=O)O)C(C)(C)CC1=O,,CO,O,[Li+].[OH-],,val
US20040176601A1,CCOC(=O)c1ccncc1.Cc1ccnc(NC(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)Nc1cc(CC(=O)c2ccncc2)ccn1,,C1CCOC1,,[Li]CCCC,,val
US20070043037A1,CN(C)c1ncc(C(=O)O)c(-c2ccccc2)n1.OCCNCC(O)c1cccc(OCc2ccccc2)c1>>CN(C)c1ncc(C(=O)N(CCO)CC(O)c2cccc(OCc3ccccc3)c2)c(-c2ccccc2)n1,,CN(C)C=O,,,,val
US04456716,CC(C)(C)c1cc(S)cc(C(C)(C)C)c1O.O=C1C=CC(=O)N1c1ccccc1>>CC(C)(C)c1cc(SC2CC(=O)N(c3ccccc3)C2=O)cc(C(C)(C)C)c1O,,CCN(CC)CC,,,,val
US04116951,CC(C)(C)OC(=O)N[C@@H](CCC(=O)OCc1ccccc1)C(=O)ON1C(=O)CCC1=O.CC(C)[C@H](N)C(=O)N[C@H](C(=O)O)C(C)C>>CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C)C(C)C)C(=O)O,,CN(C)C=O,,CCN(CC)CC,CO,val
US04395560,CCCCCCC(C)(C)c1cc(OC)c2c(c1)OC(C)(C)[C@@H]1CCC(=O)C[C@@H]21>>CCCCCCC(C)(C)c1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(=O)C[C@@H]21,,ClCCl,,BrB(Br)Br,,val
US20030139409A1,CCN(CC)C[C@H](N)[C@H](C)O.COc1cccc2c1ccc1nc3cccc(C(=O)O)c3nc12>>COc1cccc2c1ccc1nc3cccc(C(=O)N[C@@H](CN(C)C)[C@H](C)O)c3nc12,,CCN(CC)CC,,Cl,,val
US04816587,CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12.C[Si](C)(C)Br>>CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]c(Br)c(c56)C[C@H]4N(C)C3)C(=O)N12,,CO,,,,val
US20070249607A1,COC(=O)c1cc(C=NO)ccc1OC>>COC(=O)c1cc(C#N)ccc1OC,,ClCCl,,O=S(Cl)Cl,,val
US06239131B1,CC(C)(C)OC(=O)NC1CN(C2C=CCC2)c2ccccc2NC1=O>>CC(C)(C)OC(=O)NC1CN(C2CCCC2)c2ccccc2NC1=O,O=[Pt],C1CCOC1,,,,val
US20120028961A1,CN(N=O)C(=N)N[N+](=O)[O-].O=C(O)c1ccc2ncsc2c1>>COC(=O)c1ccc2ncsc2c1,,C1CCOC1,,CCOCC,[Na+].[OH-],val
US20120202776A1,CC(C)S(=O)(=O)c1ccccc1N.Clc1cc(Cl)ncn1>>CC(C)S(=O)(=O)c1ccccc1Nc1cc(Cl)ncn1,,CN(C)C=O,,[H-].[Na+],,val
US20030045532A1,ClCCN1CCCC1.Fc1ccccc1-c1nnn2c1nc(N1CCNCC1)c1ccccc12>>Fc1ccccc1-c1nnn2c1nc(N1CCN(CCN3CCCC3)CC1)c1ccccc12,,CN(C)C=O,O,CCN(CC)CC,Cl,val
US20130053563A1,CCC(C)(C)CO.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CCC(C)(C)COC(=O)Oc1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,c1ccncc1,Cl,ClCCl,val
US05571810,CS(=O)(=O)c1ccc(-c2ccsc2-c2ccc(F)cc2)cc1.O=S(=O)(O)O>>CS(=O)(=O)c1ccc(-c2cc(S(=O)(=O)O)sc2-c2ccc(F)cc2)cc1,,ClCCl,,CC(=O)OC(C)=O,,val
US20160176848A1,COC(=O)c1cc(-c2cc3c(cc2C(=O)N2Cc4ccccc4C[C@H]2C)OCO3)n2c1CC(=O)CC2>>COC(=O)c1cc(-c2cc3c(cc2C(=O)N2Cc4ccccc4C[C@H]2C)OCO3)n2c1CC(O)CC2,,CO,,Cl,[BH4-].[Na+],val
US20120178751A1,C#Cc1ccc(-c2cn3nc(-c4ccccc4F)ccc3n2)cc1[N+](=O)[O-]>>C#Cc1ccc(-c2cn3nc(-c4ccccc4F)ccc3n2)cc1N,[Fe],CCO,O,CC(=O)O,,val
US20070249670A1,COC(=O)C1(NC(=O)c2cc3ccccc3cc2NC(=O)Nc2c(C)cc(C)cc2C)CCN(C(=O)OC(C)(C)C)CC1>>COC(=O)C1(NC(=O)c2cc3ccccc3cc2NC(=O)Nc2c(C)cc(C)cc2C)CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160102073A1,COC(=O)c1c(I)ccnc1O[C@@H]1CC[C@@H](C)N(C(=O)c2ccccc2-n2nccn2)C1>>C[C@@H]1CC[C@@H](Oc2ncccc2CO)CN1C(=O)c1ccccc1-n1nccn1,,C1CCOC1,,[BH4-].[Li+],,val
US20030109459A1,COC(=O)[C@H](Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1)NC(=O)C1(Cc2ccc(OC)cc2)CCCCC1>>COc1ccc(CC2(C(=O)N[C@@H](Cc3ccc(NC(=O)c4c(Cl)cccc4Cl)cc3)C(=O)O)CCCCC2)cc1,,CCO,,[Na+].[OH-],,val
US05106863,CC(C)=CCC/C(C)=C/CCl.COc1ccc2nc(S)[nH]c2c1>>COc1ccc2[nH]c(SC/C=C(\C)CCC=C(C)C)nc2c1,,CO,,[Na+].[OH-],,val
US20030114442A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21>>CC(C)(C)OC(=O)N1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20100261771A1,CC(C)(C)OC(=O)NC(CCO)c1cccc(Cl)c1Cl>>NC(CCO)c1cccc(Cl)c1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080004301A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc(C(F)(F)F)c(O)c1C(=O)O>>Cc1ccc(C(F)(F)F)c(OC(=O)OC(C)(C)C)c1C(=O)OC(C)(C)C,,C1CCOC1,CC(C)(C)O,,,val
US20060063828A1,COC(=O)c1ccc(C(Nc2ccccc2)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1.COc1ccc(-c2cc3ccccc3s2)cc1C=O>>COC(=O)c1ccc(C(=O)Cc2cc(-c3cc4ccccc4s3)ccc2OC)cc1,,C1CCOC1,O,Cl,CC(C)(C)[O-].[K+],val
US20110039829A1,CCOC(=O)C1(Br)CCC1.CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(O)n(-c3cccc(OC)c3)n2)CC1>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OC3(C(=O)OCC)CCC3)n(-c3cccc(OC)c3)n2)CC1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100056521A1,CNC.O=[N+]([O-])c1ccc(F)c(C(F)(F)F)c1>>CN(C)c1ccc([N+](=O)[O-])cc1C(F)(F)F,,C1CCOC1,,O,[H-].[Na+],val
US05843983,CCOC(=O)N1C[C@H](OCc2ccccc2)C[C@H]1CCCl.Cc1cccc(CCc2ccccc2)c1O>>CCOC(=O)N1C[C@H](OCc2ccccc2)C[C@H]1CCOc1c(C)cccc1CCc1ccccc1,,CC(=O)N(C)C,,CC(C)(C)[O-].[K+],,val
US20080213297A1,NNC(=O)CCCCC(=O)NN.OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O>>NNC(=O)CCCCC(=O)NNC1OC(CO)C(OC2OC(CO)C(O)C(O)C2O)C(O)C1O,,O,,CC#N,,val
US04595521,CCCC=O.CCOC(=O)/C=C\C(=O)OCC>>CCCC(=O)C(CC(=O)OCC)C(=O)OCC,O=C(OOC(=O)c1ccccc1)c1ccccc1,,,,,val
US20130079328A1,NCc1ccc(Br)cc1.O=C(O)c1ccc(-c2ccccc2)cc1>>O=C(NCc1ccc(Br)cc1)c1ccc(-c2ccccc2)cc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140148472A1,CC(Cl)C(=O)Cl.Nc1ccccc1>>CC(Cl)C(=O)Nc1ccccc1,,CC#N,O,CN(C)C=O,Cl,val
US20100075948A1,N#CCc1ccc(Cl)cc1F.O=Cc1cccc(Br)c1F>>N#C/C(=C\c1cccc(Br)c1F)c1ccc(Cl)cc1F,,CO,,C[O-].[Na+],,val
US06936602B1,COC(=O)C1=Cc2cc(-c3ccc(N4CCOCC4)cc3)ccc2NCC1.O=CO>>COC(=O)C1=Cc2cc(-c3ccc(N4CCOCC4)cc3)ccc2N(C=O)CC1,,C1CCOC1,,CC(=O)O,,val
US20160272632A1,CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@@H](C(=O)O)OC1.CN(C)C(OC(C)(C)C)OC(C)(C)C>>CC(C)(C)OC(=O)[C@@H]1CC[C@@H](O[Si](C)(C)C(C)(C)C)CO1,,Cc1ccccc1,,,,val
US06610692B1,CCOC(=O)Cn1c(Cl)cnc(N[C@@H]2CN(S(C)(=O)=O)C[C@H]2c2ccccn2)c1=O>>CS(=O)(=O)N1C[C@@H](Nc2ncc(Cl)n(CC(=O)O)c2=O)[C@H](c2ccccn2)C1,,CCO,,Cl,[Na+].[OH-],val
US05618839,CC1(C)CCC(=O)c2cc([N+](=O)[O-])ccc21.O=S(=O)(N(c1ccccn1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC1(C)CC=Cc2cc([N+](=O)[O-])cc(OS(=O)(=O)C(F)(F)F)c21,,O,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20140179666A1,C=C(C)CBr.COc1cc2c(cn1)N(C(=O)OC(C)(C)C)C(=O)C2(C)C>>C=C(C)Cn1cc2c(cc1=O)C(C)(C)C(=O)N2C(=O)OC(C)(C)C,,CCOC(C)=O,,Cl,,val
US20110263598A1,NC(=O)CCl.O=C1Nc2ccccc2C1=O>>NC(=O)CN1C(=O)C(=O)c2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04629495,CO.N#Cc1cnn(-c2ccc(Cl)c(Cl)c2Cl)c1N(C(=O)Oc1ccccc1)C(=O)Oc1ccccc1>>COC(=O)Nc1c(C#N)cnn1-c1ccc(Cl)c(Cl)c1Cl,,CO,,,,val
US20030166676A1,Cn1cc(S(=O)CCl)c(=O)c2ccc(F)cc21.O=S(Cl)Cl>>Cn1cc(SC(Cl)Cl)c(=O)c2ccc(F)cc21,,c1ccncc1,,,,val
US06169107A,COC(=O)c1ccc(OCc2ccccc2)cc1C>>Cc1cc(OCc2ccccc2)ccc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130012492A1,ClCc1ncccn1.O=C1NCCOc2ccc(Br)cc21>>O=C1c2cc(Br)ccc2OCCN1Cc1ncccn1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20110136764A1,CCOC(=O)c1nc(C2CCC3(CC2)OCCO3)ccc1N>>Nc1ccc(C2CCC3(CC2)OCCO3)nc1C(=O)O,,C1CCOC1,O,CO,[Li+].[OH-],val
US20070135415A1,CS(=O)(=O)Cl.Nc1cc2c3c(c(-c4ccccc4)[nH]c3c1)C=NNC2=O>>CS(=O)(=O)Nc1cc2c3c(c(-c4ccccc4)[nH]c3c1)C=NNC2=O,,ClCCl,c1ccncc1,,,val
US20060079572A1,CCOCC(=O)OC(CC)C(C)C1OC1CC(C)/C=C/C=C(\C)C1OC(=O)CC(O)CCC(C)(OC(C)OCC)C(OC(C)=O)C=CC1C>>CCOCC(=O)OC(CC)C(C)C1OC1CC(C)/C=C/C=C(\C)C1OC(=O)CC(O)CCC(C)(O)C(OC(C)=O)C=CC1C,,CCOC(C)=O,CO,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20110046191A1,Cc1cnc(C(=O)c2ccccc2)o1.O=C1CCC(=O)N1Br>>O=C(c1ccccc1)c1ncc(CBr)o1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US05869485,CN(C)C=O.Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2-c1cccc(OCCCCl)c1.[Na]c1ncc[nH]1>>N.Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2-c1cccc(OCCCn2ccnc2)c1,,CN(C)C=O,,O,,val
US20080051458A1,CC(C)C(OC(=O)ON1C(=O)CCC1=O)OC(=O)c1ccccc1.CNCC(=O)O>>CC(C)C(OC(=O)c1ccccc1)OC(=O)N(C)CC(=O)O,,CC#N,O,,,val
US07317009B2,COC(=O)COCCO.II>>COC(=O)COCCI,,CC#N,CCOCC,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120330030A1,CC(=O)/C=C/C(=O)O.CCN>>CC/C(=C\C(C)=O)C(N)=O,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20150329538A1,CS(=O)(=O)C1CNC1.Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1F>>Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N1CC(S(C)(=O)=O)C1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20030069434A1,CN.C[C@]12C[C@H](F)[C@@H]3c4ccc(O)cc4C[C@@H](CCCCCCI)[C@H]3[C@@H]1CCC2=O>>CNC(C)CCCC[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)C(=O)CC[C@H]3[C@H]12,,C1CCOC1,,,,val
US20070015774A1,CCONC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C>>CCONC(=O)[C@@H](N)C(C)C,,C1COCCO1,CO,O=S(=O)(O)O,,val
US20160194332A1,C=C[C@@H](Cn1c(Br)c(-c2cnc3ccccc3c2)c2c(N)ncnc21)NC(=O)OC(C)(C)C>>C=C1c2c(-c3cnc4ccccc4c3)c3c(N)ncnc3n2C[C@H]1NC(=O)OC(C)(C)C,,C1CCOC1,,[Na+].[OH-],,val
US20080070884A1,COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)OCc1ccccc1>>CC(C)C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)O,,C1CCOC1,O,CC(=O)O,[Li+].[OH-],val
US20150056141A1,CCOC(=O)c1c(NC(C)=O)sc2c(OCCN(CC)CC)c(Br)ccc12.OB(O)c1ccc(F)cc1>>CCOC(=O)c1c(NC(C)=O)sc2c(OCCN(CC)CC)c(-c3ccc(F)cc3)ccc12,,CC#N,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US06172108B2,NCCCCCC(=O)O.O=S(=O)(Cl)c1ccc2ccccc2c1>>O=C(O)CCCCCNS(=O)(=O)c1ccc2ccccc2c1,,[Na+],[OH-],,,val
US05194614,COc1ccc2cccc(CC(=O)O)c2c1.O=S(Cl)Cl>>COc1ccc2cccc(CC(=O)Cl)c2c1,,ClC(Cl)Cl,,,,val
US20060189613A1,COc1nnc(Cl)nc1N.O=S(=O)(Cl)c1cccc(Cl)c1Cl>>COc1nnc(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl,,CCOC(C)=O,COCCOC,CO,[H-].[Na+],val
US20110230495A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.COC(=O)c1cnccc1Br>>COC(=O)c1cnccc1C1=CCN(C(=O)OC(C)(C)C)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2c(F)cc(O[C@H]3CC(F)(F)CC[C@@H]3c3ccnn3C)cc2F)c(OC)c1>>Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1cc(F)c(S(=O)(=O)Nc2ccncn2)c(F)c1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US05449785,C=C(C)[C@@H]1CCC(C)(C)[C@H](O)[C@H]1C(=O)OC.CI>>C=C(C)[C@@H]1CCC(C)(C)[C@H](OC)[C@H]1C(=O)OC,,CN(C)C=O,,[H-].[Na+],,val
US20130022644A1,CC(C)c1cccc(C(C)C)c1NC(=O)CCl.CCCC1(C)C(=O)NC(=O)N1c1ccc(C)cc1>>CCCC1(C)C(=O)N(CC(=O)Nc2c(C(C)C)cccc2C(C)C)C(=O)N1c1ccc(C)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060074084A1,CCOC(=O)c1[nH]c2ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc2c1-c1ccncc1>>CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3[nH]c(C(=O)O)c(-c4ccncc4)c3c2)cc1,,CCO,O,[Na+].[OH-],,val
US20100197744A1,COC(=O)CN(c1cc(OCc2ccccc2)cc2ccc(OC)cc12)S(=O)(=O)NC(=O)OC(C)(C)C>>COC(=O)CN(c1cc(OCc2ccccc2)cc2ccc(OC)cc12)S(N)(=O)=O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100113512A1,CC(C)(C)OC(=O)N(Cc1ccc(-c2cccc(C=O)c2)cc1)C1Cc2ccccc2C1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>Cc1ccc(S(=O)(=O)C2N=COC2c2cccc(-c3ccc(CN(C(=O)OC(C)(C)C)C4Cc5ccccc5C4)cc3)c2)cc1,,CCO,O,[C-]#N.[Na+],,val
US20070191447A1,Cn1c(=O)n(C(=O)OC(C)(C)C)c2ccc(Br)cc21>>Cn1c(=O)[nH]c2ccc(Br)cc21,,CC(=O)O,,C1COCCO1,Cl,val
US20100048570A1,CCOC(=O)[C@@H](Nc1ccc(CNC(=O)OC(C)(C)C)cc1)C(C)C>>CCOC(=O)[C@@H](Nc1ccc(CN)cc1)C(C)C,,ClCCl,,C1COCCO1,Cl,val
US20110319394A1,CC(C)n1c(=O)n(-c2ccc(O)cc2)c2ncccc21.Cn1c(S(C)(=O)=O)nc2cccnc21>>CC(C)n1c(=O)n(-c2ccc(Oc3nc4cccnc4n3C)cc2)c2ncccc21,,CN(C)C=O,CO,[H-].[Na+],,val
US05817682,CON=C(OC)C(=O)c1ncsc1C.O=C1CCC(=O)N1Br>>CON=C(OC)C(=O)c1ncsc1CBr,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20130261106A1,CC(C)n1nc(C2CCNCC2)cc1Nc1ncc2sc(C(N)=O)c(-c3ccccc3OC(F)(F)F)c2n1>>CC(C)n1nc(C2CCNCC2)cc1Nc1ncc2sc(C(N)=O)c(-c3ccccc3OC(F)(F)F)c2n1,,CCOC(C)=O,,Cl,[Na+].[OH-],val
US20050234062A1,COc1ccc(C2=NN(C3CCN(c4ccc([N+](=O)[O-])cc4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC.O=c1ccc2ccc(CCl)cc2o1>>COc1ccc(C2=NN(C3CCN(Cc4ccc5ccc(=O)oc5c4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC.Cl,,O,,,,val
US20070265326A1,COc1ccc(F)cc1C(C)(C)C[C@@](O)(CO)C(F)(F)F>>COc1ccc(F)cc1C(C)(C)C[C@]1(C(F)(F)F)CO1,,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US20060063841A1,NOc1ccc(F)cc1.O=C(c1cc(Cl)ccc1NS(=O)(=O)C(F)(F)F)C1CCCCC1>>O=S(=O)(Nc1ccc(Cl)cc1C(=NOc1ccc(F)cc1)C1CCCCC1)C(F)(F)F,,CCO,,Cl,CC(=O)[O-].[Na+],val
US06417009B1,COCC1(CO)CSSC1.O=S1(=O)OCCO1>>COCC1(COCCO)CSSC1,,C1CCOC1,,Cl,[H-].[Na+],val
US20020028406A1,C=CC(=O)OCCO.C[SiH]1O[SiH](C)O[SiH](C)O[SiH](C)O1>>C=CC(=O)OCCO[Si]1(C)O[SiH](C)O[SiH](C)O[SiH](C)O1,,O,,c1ccccc1,,val
US04298535,CC(=O)C1CCC2=C(C1)C1OC2c2cc3ccccc3cc21.O=C(O)C(F)(F)F>>CC(=O)C1CCC2=C(C1)C(=O)c1cc3ccccc3cc1C2=O,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20110160151A1,CC(=O)Cl.OC[C@H]1OC=C[C@@H](O)[C@@H]1OCc1ccccc1>>CC(=O)OC[C@H]1OC=C[C@@H](O)[C@@H]1OCc1ccccc1,,ClCCl,,c1ccncc1,,val
US20050272779A1,CCC(O)C#N.NO.O=C(Cl)c1cccc(Cl)c1>>CCC(O)c1noc(-c2cccc(Cl)c2)n1,,c1ccncc1,,O=C([O-])O.[Na+],,val
US20150166564A1,COCCN1C[C@@H](N)[C@H](c2ccc(F)c(F)c2)C1.Cc1c(-c2cnn(C)c2)nn(-c2cncc(F)c2)c1N.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COCCN1C[C@@H](NC(=O)Nc2c(C)c(-c3cnn(C)c3)nn2-c2cncc(F)c2)[C@H](c2ccc(F)c(F)c2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04179505,CCCNc1ccc(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1N.CCOC(OCC)OCC>>CCCn1cnc2cc(CN3CCN(C(c4ccccc4)c4ccccc4)CC3)ccc21,,CC(=O)O,,,,val
US20140107151A1,CCOC(=O)CC(=O)C1CCN(C(=O)OCc2ccccc2)CC1.N#CC=C(N)c1ccc(Oc2ccccc2)cc1>>N#Cc1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C2CCN(C(=O)OCc3ccccc3)CC2)cc1=O,,CC(=O)N(C)C,O,,,val
US06075029,CC(=O)O[C@H](C)CCCCI.Cc1nc2c(c(=O)[nH]c(=O)n2Cc2ccco2)n1COC(=O)C(C)(C)C>>CC(=O)O[C@H](C)CCCCn1c(=O)c2c(nc(C)n2COC(=O)C(C)(C)C)n(Cc2ccco2)c1=O,,CS(C)=O,,[H-].[Na+],,val
US20070043107A1,CCC(=O)C1(C(=O)OC)CCOCC1>>CCC(=O)C1CCOCC1,,O,,O=S(=O)(O)O,[Na+].[OH-],val
US20150225412A1,C[C@H](N(Cc1ccc(NC[C@@H]2CCCN2C(=O)OC(C)(C)C)c(N)c1)C(=O)OCc1ccccc1)C(C)(C)C.N#CBr>>C[C@H](N(Cc1ccc2c(c1)[nH]c(=N)n2C[C@@H]1CCCN1C(=O)OC(C)(C)C)C(=O)OCc1ccccc1)C(C)(C)C,,CCO,,,,val
US04388104,C=CC(C)=O.Cc1ccccc1.Oc1ccc(O)cc1>>CC(=O)C1CCC=C(C)O1,,Cc1ccccc1,,,,val
US05656645,CCOC(=O)Cn1c(=O)c(NS(=O)(=O)Cc2ccccc2)cn(COC)c1=O>>COCn1cc(NS(=O)(=O)Cc2ccccc2)c(=O)n(CC(=O)O)c1=O,,CO,O,[Na+].[OH-],,val
US20030087882A1,COC(=O)c1ccc(C2=CCS(=O)(=O)c3ccccc32)cc1>>COC(=O)c1ccc(C2CCS(=O)(=O)c3ccccc32)cc1,,CO,,,,val
US20050043544A1,CCOC(=O)C[Zn]Br.CCOC(C)=O.COc1ccc(C#N)cc1>>CCOC(=O)CC(=O)c1ccc(OC)cc1,,C1CCOC1,,Cl,,val
US20070265270A1,COc1ccc(C2OCC(=O)NC2C)cc1>>COc1ccc(C2OCCNC2C)cc1,,C1CCOC1,,,,val
US20120101103A1,COC(=O)C(C#N)c1ncc(Cl)cc1Cl>>N#CCc1ncc(Cl)cc1Cl,,CS(C)=O,O,[Cl-].[Na+],,val
US04751227,Cc1[nH]c(=O)c(C#N)cc1-c1ccc2nccn2c1.O=C1CCC(=O)N1Cl>>Cc1[nH]c(=O)c(C#N)cc1-c1ccc2ncc(Cl)n2c1,,CN(C)C=O,,,,val
US05464864,NNc1ccc(Br)cc1.O=C1CCC(N2C(=O)c3ccccc3C2=O)CC1>>O=C1c2ccccc2C(=O)N1C1CCc2[nH]c3ccc(Br)cc3c2C1,,CCCCO,,Cl,,val
US20050277627A1,COc1cc2c(c(OC)c1OC)-c1ccc(OC(=O)c3cccc(CN4CCN(C(=O)OC(C)(C)C)CC4)c3)cc1[C@@H](NC(C)=O)CC2>>COc1cc2c(c(OC)c1OC)-c1ccc(OC(=O)c3cccc(CN4CCNCC4)c3)cc1[C@@H](NC(C)=O)CC2,,ClCCl,,CCOCC,Cl,val
US20160137636A1,CI.N#Cc1cc(I)c(O)nc1-c1cc(F)cc(F)c1>>COc1nc(-c2cc(F)cc(F)c2)c(C#N)cc1I,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140322247A1,CC(C)[C@H](NC(=O)CCCCCN1C(=O)C=CC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)Oc2ccc([N+](=O)[O-])cc2)cc1.C[C@H](O)C(=O)N(C[C@@H]1CNC[C@@H]1F)[C@@H](c1nc(-c2cc(F)ccc2F)cn1Cc1ccccc1)C1CCOCC1>>CC(C)[C@H](NC(=O)CCCCCN1C(=O)C=CC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)N2C[C@H](F)[C@H](CN(C(=O)[C@H](C)O)[C@@H](c3nc(-c4cc(F)ccc4F)cn3Cc3ccccc3)C3CCOCC3)C2)cc1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US06423840B1,C=CCOC(=O)NC(C=O)CCC(=O)OC(C)(C)C.NNC(N)=O>>C=CCOC(=O)NC(C=O)CCC(=NNC(N)=O)OC(C)(C)C,,CO,,CC(=O)[O-].[Na+],,val
US20060100229A1,CCn1cc2c(n1)c(Cl)nc1cc(OCc3ccccc3)ccc12.N>>CCn1cc2c(n1)c(N)nc1cc(OCc3ccccc3)ccc12,,CO,,,,val
US20050124498A1,CC(=O)OC(C)=O.CO.Cc1cccc(F)c1C(=O)C#N>>COC(=O)C(=O)c1c(C)cccc1F,,COC(C)(C)C,,Cl,,val
US20030119842A1,CC(=O)Cl.Nc1cnccn1.O=Cc1ccccc1.[C-]#[N+]C(C)(C)C>>CC(=O)[n+]1c(-c2ccccc2)c(NC(C)(C)C)n2ccncc21.[Cl-],,[O-][Cl+3]([O-])([O-])O,,,,val
US20070112002A1,CC1(C)CCC(c2ccccc2N2CCN(C(=O)OC(C)(C)C)CC2)CC1.CCOC(C)=O.ClCCl>>CCC1(CC)CCC(c2ccccc2N2CCNCC2)CC1,,O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20070149533A1,C[Si](C)(C)n1cncn1.O=[N+]([O-])c1cc[n+]([O-])c(Cl)c1>>O=[N+]([O-])c1cc[n+]([O-])c(-n2cncn2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100121048A1,CCOC(=O)COc1ccc(-c2c(C(=O)N3CCN(Cc4ccccc4)C[C@H]3Cc3ccccc3)cc(C)n2-c2cccc(OC)c2OC)cc1.Cl>>CCOC(=O)COc1ccc(-c2c(C(=O)N3CCNC[C@H]3Cc3ccccc3)cc(C)n2-c2cccc(OC)c2OC)cc1.Cl,[Pd],CCO,,,,val
US20130187136A1,Br[Mg]c1ccccc1.C1COCCO1.CCOC(C)=O.Clc1nc(-c2ccccc2)cc2cc3cc4c(Cl)nc(-c5ccccc5)cc4cc3cc12>>c1ccc(-c2cc3cc4cc5c(-c6ccccc6)nc(-c6ccccc6)cc5cc4cc3c(-c3ccccc3)n2)cc1,,C1COCCO1,CCOC(C)=O,,,val
US04205074,CBr.c1ccc(C(=C2CCN3CCCCC23)c2ccccc2)cc1>>CBr.c1ccc(C(=C2CCN3CCCCC23)c2ccccc2)cc1,,CC(C)=O,,,,val
US20130245305A1,Nc1cccc(C(=O)O)c1.S=C(n1ccnc1)n1ccnc1>>O=C(O)c1cccc(N=C=S)c1,,CCCCCCC,ClCCl,CCN(CC)CC,Cl,val
US20100075960A1,CC(C)(C)OC(=O)/N=N/C(=O)OC(C)(C)C.COC(=O)c1sc(-n2cnc3cc(OC(F)(F)F)ccc32)cc1O.C[C@H](O)c1cccc(O[Si](C)(C)C(C)(C)C)c1Cl.ClCCl>>COC(=O)c1sc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc1O[C@H](C)c1cccc(O[Si](C)(C)C(C)(C)C)c1Cl,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05571810,CS(=O)(=O)c1ccc(-c2cc(C#N)sc2-c2ccc(NCC=O)cc2)cc1>>CNc1ccc(-c2sc(C#N)cc2-c2ccc(S(C)(=O)=O)cc2)cc1,,C1CCOC1,CO,Cl,,val
US06413987B1,CN1CCCCC1CO.O=S(Cl)Cl>>CN1CCCCC1CCl,,ClC(Cl)Cl,,,,val
US20120277212A1,C1CCNC1.CC(C)(C)ON=c1cc(-c2cc3cccn3cn2)oc2ccc(OCCCl)cc12>>CC(C)(C)ON=c1cc(-c2cc3cccn3cn2)oc2ccc(OCCN3CCCC3)cc12,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04677115,O=C1CCCSc2ccsc21>>OC1CCCSc2ccsc21,,CCO,,[BH4-].[Na+],,val
US20090062292A1,Cc1cc(C(=O)N(C)C)ccc1[N+](=O)[O-]>>Cc1cc(C(=O)N(C)C)ccc1N,,CO,,,,val
US20080132539A1,CC(C)(C)OC(=O)N[C@@H](CCc1nc2ccccc2[nH]1)C(=O)OCc1ccccc1.CCCI>>CCCn1c(CC[C@H](NC(=O)OC(C)(C)C)C(=O)OCc2ccccc2)nc2ccccc21,,C1CCOC1,,Cl,[H-].[Na+],val
US20070191333A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(c1ccccc1)N1CCC(CN)C1>>CC(c1ccccc1)N1CCC(CNC(=O)OC(C)(C)C)C1,,C1CCOC1,,,,val
US20160060257A1,COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCC(=O)CC3)cc12>>COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCC(O)CC3)cc12,,CO,,[BH4-].[Na+],,val
US05958954,COc1ccc(SC(C)(C)CC(=O)O)cc1.O=C(Cl)C(=O)Cl>>COc1ccc(SC(C)(C)CC(=O)Cl)cc1,,c1ccccc1,,,,val
US05998436,CCOC(=O)C(=CNc1cnc(Cl)c(N)c1)C(=O)c1cc(F)c(F)c(Cl)c1F>>CCOC(=O)c1cn(-c2cnc(Cl)c(N)c2)c2c(Cl)c(F)c(F)cc2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160024077A1,COC(=O)c1cc2c(O)c(C(=O)OC(C)(C)C)c(C)cn2n1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1cc2c(OS(=O)(=O)C(F)(F)F)c(C(=O)OC(C)(C)C)c(C)cn2n1,,ClCCl,,CCN(CC)CC,,val
US20130274243A1,N#Cc1ccc(-c2cc([N+](=O)[O-])c(N)cc2F)cc1>>N#Cc1ccc(-c2cc(N)c(N)cc2F)cc1,[Zn],CO,,[Cl-].[NH4+],,val
US04610991,Clc1ccncc1.Nc1cccc(C(=O)O)c1>>O=C(O)c1cccc(Nc2ccncc2)c1,,CC(=O)O,,,,val
US20070219198A1,O=S(=O)(c1cccc(Cl)c1)C1CCNCC1.O=[N+]([O-])c1ccc(Cl)nc1>>O=[N+]([O-])c1ccc(N2CCC(S(=O)(=O)c3cccc(Cl)c3)CC2)nc1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US04440940,C1=COCCC1.CCCCCCCCCC=CCCCNc1cccc(C(=O)O)c1>>CCCCCCCCCC=CCCCNc1cccc(C(=O)OC2CCCCO2)c1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110275622A1,COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)NCCCCCCCCO)c4)cc23)c1>>COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)NCCCCCCCC=O)c4)cc23)c1,,CN(C)C=O,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20070072920A1,COCC=Cc1cc(OC)c(C[C@@H](C)NC(=O)C(F)(F)F)cc1OC>>COCCCc1cc(OC)c(C[C@@H](C)NC(=O)C(F)(F)F)cc1OC,[Pd],CCO,,,,val
US20060160811A1,CC1CCN(c2c(-c3c(F)cc(F)cc3F)c(OCc3ccccc3)nc3ncncc23)CC1>>CC1CCN(c2c(-c3c(F)cc(F)cc3F)c(O)nc3ncncc23)CC1,[Pd],CO,,[H][H],,val
US07074801B1,CC(C)(C)OC(=O)N1CCNCC1.COc1cccc(CCl)c1>>COc1cccc(CN2CCNCC2)c1,,C1CCOC1,,CCN(CC)CC,,val
US20110015119A1,COC(=O)COCCOc1ccc([N+](=O)[O-])cc1>>O=C(O)COCCOc1ccc([N+](=O)[O-])cc1,,CCO,,O,[Li]O,val
US04837333,C=CCCBr.Cc1ccc(C(=O)O)cc1>>C=CCCCc1ccc(C(=O)O)cc1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20050288273A1,CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCC(C(=O)c2cscn2)C3=O)C(=O)O1.NN>>CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCc2c(-c4cscn4)n[nH]c2-3)C(=O)O1,,CCO,,O,,val
US05208250,COc1cccc(C=O)c1OC.O=C1CSC(=S)N1>>COc1cccc(C=C2SC(=S)NC2=O)c1OC,,O,,CC(=O)O,CC(=O)[O-].[Na+],val
US20050261291A1,COc1ccc(F)cc1C1=CCN(C(=O)OC(C)(C)C)CC1>>COc1ccc(F)cc1C1CCN(C(=O)OC(C)(C)C)CC1,[Pd],CO,,,,val
US04214094,CCOC(=O)C(C)(C)Oc1ccc(CNc2ccc(Cl)cc2)cc1>>CC(C)(Oc1ccc(CNc2ccc(Cl)cc2)cc1)C(=O)O,,CCO,,[Na+].[OH-],,val
US20090298807A1,CC(C)(Cc1cccc(C=O)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OC(=O)OC(C)(C)C)c2[nH]c(=O)ccc12>>CC(C)(Cc1cccc(C=O)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c2[nH]c(=O)ccc12,,CO,,N,,val
US20030212055A1,O=CN1CCN(CCCO)CC1>>OCCCN1CCNCC1,,CO,Cl,,,val
US20120232056A1,COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCN(S(C)(=O)=O)CC3)nc2c1>>CS(=O)(=O)N1CCN(c2nc3cc(C(=O)O)ccc3nc2-c2ccc(F)cc2)CC1,,CO,,O,[Na+].[OH-],val
US20140094475A1,Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1.O=C(O)/C=C/c1ccc(O)cc1>>Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1.O=C([O-])/C=C/c1ccc(O)cc1,,CO,,,,val
US20150329538A1,Nc1ccc(F)cc1F.O=C1NCCc2[nH]c(-c3cccc4ccc(Cl)nc34)cc21>>O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5ccc(F)cc5F)nc34)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20160193206A1,N[C@@H]1CC[C@@H](N2CCN(CC3CC3)CC2)CC1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>O=[N+]([O-])c1ccc(S(=O)(=O)N[C@@H]2CC[C@@H](N3CCN(CC4CC4)CC3)CC2)cc1,,ClCCl,,CCN(CC)CC,,val
US20060111440A1,CC(C)(F)C[C@H](N[C@@H](c1ccc(Br)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(C)(F)C[C@H](N[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1,Cl[Pd]Cl,C1COCCO1,CCOCC,ClCCl,CC(=O)[O-].[K+],val
US05399563,CCCCC(CC)COc1ccc(C=O)cc1.O=C1CN2CCC1CC2>>CCCCC(CC)COc1ccc(C=C2C(=O)C3CCN2CC3)cc1,,CCO,O,[Na+].[OH-],,val
US20050203078A1,COC(=O)c1ccc(N2CCCCC2=O)c(C)c1>>Cc1cc(C(=O)O)ccc1N1CCCCC1=O,,CO,,[Na+].[OH-],,val
US20100174065A1,CC(C)(C)OC(=O)N1CCOc2cc(OCc3ccccc3)ccc2C1>>CC(C)(C)OC(=O)N1CCOc2cc(O)ccc2C1,[Pd],C1CCOC1,CCO,,,val
US20160264575A1,CC(C)(C)OC(=O)N1Cc2[nH]c3ccccc3c2C(C)(C)C1C(=O)O.CC(C)=O.CC1(C)c2c(n(Cc3ccc(F)cc3)c3ncccc23)CNC1C(=O)O>>CC(C)(C)OC(=O)CCN1C(=O)C2N(Cc3c(c4cccnc4n3Cc3ccc(F)cc3)C2(C)C)C1=O,,CS(C)=O,O,CCN(CC)CC,,val
US20060276464A1,C1CCNC1.CC(C)(C)OC(=O)NC1CCN(C(=O)c2ccc(Cl)nc2)CC1>>CC(C)(C)OC(=O)NC1CCN(C(=O)c2ccc(N3CCCC3)nc2)CC1,,C1CCOC1,,,,val
US05521147,CC1(C)CCc2ccc(F)c(N)c2O1.O=C1CCC(=O)N1Cl>>CC1(C)CCc2c(Cl)cc(F)c(N)c2O1,,CN(C)C=O,,,,val
US20050203296A1,CCc1nc2c(s1)Nc1ccccc1NC2=S.COS(=O)(=O)C(F)(F)F.Fc1cccc([C@H]2CNCCN2)c1.c1ccncc1>>CCc1nc2c(s1)Nc1ccccc1N=C2N1CCN[C@@H](CCc2cccc(F)c2)C1,,c1ccncc1,,ClCCl,,val
US20080153836A1,CCCC[Sn](CCCC)(CCCC)c1ccnn1C(C)C.COC(=O)c1cc(I)c(C(C)F)cc1N>>COC(=O)c1cc(-c2ccnn2C(C)C)c(C(C)F)cc1N,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,,,val
US20070249670A1,CC(C)(C)OC(=O)[C@@H](NC(=O)c1ccc(S(C)(=O)=O)cc1N)C1CCCCC1.Cc1cc(C)c(N=C=O)c(C)c1>>Cc1cc(C)c(NC(=O)Nc2cc(S(C)(=O)=O)ccc2C(=O)N[C@H](C(=O)OC(C)(C)C)C2CCCCC2)c(C)c1,,c1ccncc1,,CCCCCC,CCOC(C)=O,val
US20120214766A1,CC(C)(CO)NC(=O)c1nn(-c2ccc(Br)cn2)c2c1C[C@@H]1C[C@H]21.N#C[Zn]C#N>>CC(C)(CO)NC(=O)c1nn(-c2ccc(C#N)cn2)c2c1C[C@@H]1C[C@H]21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(=O)N(C)C,,,,val
US04383945,C=CC[C@@H]1[C@@H](C(C)(C)O)C(=O)N1C(C(=O)OC)=C(C)C.O=C(Cl)OCc1ccc([N+](=O)[O-])cc1>>C=CC[C@@H]1[C@@H](C(C)(C)OC(=O)OCc2ccc([N+](=O)[O-])cc2)C(=O)N1C(C(=O)OC)=C(C)C,,C1CCOC1,,CC(=O)O,[Li]CCCC,val
US20090318408A1,CI.O=C1Nc2cnc(Cl)nc2N(CCc2cccs2)CC1(F)F>>CN1C(=O)C(F)(F)CN(CCc2cccs2)c2nc(Cl)ncc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05405851,Cc1cc2nc(NC(=O)C(C)(C)C)[nH]c(=O)c2c2ccccc12.O=C1CCC(=O)N1Br>>CC(C)(C)C(=O)Nc1nc2cc(CBr)c3ccccc3c2c(=O)[nH]1,,c1ccccc1,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20090209536A1,CC(C)S(=O)(=O)Cl.Clc1ccccc1-c1nc(N2CCNCC2)c2ccccc2n1>>CC(C)S(=O)(=O)N1CCN(c2nc(-c3ccccc3Cl)nc3ccccc23)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20060229309A1,CC(C)I.CCCO[C@@H]1C[C@H]([C@@H](O[Si](C)(C)C(C)(C)C)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(O)cc(N3CCCC3=O)c2)N(C(=O)OC(C)(C)C)C1>>CCCO[C@@H]1C[C@H]([C@@H](O[Si](C)(C)C(C)(C)C)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(OC(C)C)cc(N3CCCC3=O)c2)N(C(=O)OC(C)(C)C)C1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US04746648,COC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1>>COC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)N,[Pd],CO,,O=C[O-].[NH4+],,val
US20160096804A1,CO.COC(=O)c1ccc(CN(c2cc(-c3ccc(F)cc3)ccn2)c2nc(C)ns2)cc1.NO>>NO.O=C(NO)c1ccc(CN(c2ccccn2)c2nc3ccccc3s2)cc1,,CO,,Cl,[K+].[OH-],val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n([C@@H]2C[C@@H](OCC(C)(C)O)C2)c2ncnn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2F)c(=O)n([C@@H]2C[C@@H](OCC(C)(C)O)C2)c2ncnn12,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20120225867A1,C[C@@H](Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1)NC(=O)c1coc(CCl)n1.O=C1CCC(=O)N1>>C[C@@H](Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1)NC(=O)c1coc(CN2C(=O)CCC2=O)n1,,CN(C)C=O,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US05753657,O=c1[nH]c2c3ccccc3c(=Cc3ccco3)c2n2ccnc12>>O=c1[nH]c2c(n3ccnc13)C(Cc1ccco1)c1ccccc1-2,[Pd],CN(C)C=O,,,,val
US20140171403A1,CC1CC(CNC(=O)OC(C)(C)C)CCN1C(=O)OCc1cc(Cl)cc(Cl)c1>>CC1CC(CN)CCN1C(=O)OCc1cc(Cl)cc(Cl)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06319920B1,CCN(CC1CCN(C(=O)OC(C)(C)C)CC1)[C@@H](C)Cc1ccc2c(c1)CCO2>>CCN(CC1CCNCC1)[C@@H](C)Cc1ccc2c(c1)CCO2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100075942A1,C1CNC1.CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(-c2ncc(CO)cc2F)cc1>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(-c2ncc(CN3CCC3)cc2F)cc1,,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US20130034504A1,BrCCCCCC1OCCO1.O=Cc1ccc(O)cc1>>O=Cc1ccc(OCCCCCC2OCCO2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US05801249,CC1(C)OC(=O)N[C@H]1Cc1ccccc1.CCC(=O)Cl>>CCC(=O)N1C(=O)OC(C)(C)[C@@H]1Cc1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US04492700,C[Si](C)(C)C#N.ClSc1nccnc1Cl>>N#CSc1nccnc1Cl,,CC#N,,,,val
US20140148433A1,Cn1c(=O)[nH]c2nc(-c3nn(Cc4ccccc4F)c4ncccc34)nc(I)c21>>Cn1c(=O)[nH]c2nc(-c3nn(Cc4ccccc4F)c4ncccc34)ncc21,[Pd],CN(C)C=O,,,,val
US08445509B2,O=C(Nc1cn2cc(Oc3ccc([N+](=O)[O-])cc3F)ccc2n1)C1CC1>>Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1,,C1CCOC1,,CO,,val
US20160221945A1,Cc1cc(CNC(=O)[C@@H]2C[C@@H](F)CN2C(=O)OC(C)(C)C)cc(-c2cnc(C(F)(F)F)nc2)n1>>Cc1cc(CNC(=O)[C@@H]2C[C@@H](F)CN2)cc(-c2cnc(C(F)(F)F)nc2)n1,,C1COCCO1,,Cl,,val
US04845129,COc1cc(CC(=O)C(CCO)c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC>>COc1cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)C2=O)cc(OC)c1OC,[Pd],CCO,,[H][H],,val
US20150011508A1,Cc1ccc(C#N)cc1N.NO>>Cc1ccc(C(=N)NO)cc1N,,CCO,,,,val
US20060166983A1,CCOC(=O)c1cc2cc(OCC(C)c3oc(-c4ccc(C(F)(F)F)cc4)nc3C(C)C)ccc2[nH]1.CI>>CCOC(=O)c1cc2cc(OCC(C)c3oc(-c4ccc(C(F)(F)F)cc4)nc3C(C)C)ccc2n1C,,O,,[H-].[Na+],,val
US06197760B1,Cl.ClCCl.NCCO.O=S(=O)(Cl)Cl>>CS(=O)(=O)OCCN.Cl,[Pd],C1COCCO1,ClCCl,CCN(CC)CC,,val
US04857558,CC(C)(C)c1cc(S)cc(C(C)(C)C)c1O.CCC(=O)CBr>>CCC(=O)CSc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,,CCOCC,,CCN(CC)CC,,val
US20120289526A1,CC(C)c1cccc(O)c1.O=[N+]([O-])c1cnc(Cl)nc1>>CC(C)c1cccc(Oc2ncc([N+](=O)[O-])cn2)c1,,CC#N,,CCN(CC)CC,,val
US20070075632A1,Ic1c2ccccc2c(-c2ccccc2)c2ccccc12.OB(O)c1ccc(Br)cc1>>Brc1ccc(-c2c3ccccc3c(-c3ccccc3)c3ccccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20150175557A1,CC(C)(C)OC(=NO)NC1CC(=NO)C1(C)C>>CC(C)(C)OC(=O)NC1CC(N)C1(C)C,[Ni],N,,CO,,val
US20040157836A1,C=Cc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(=O)OC)c1OCC>>CCOc1c(CC)ccc(NS(=O)(=O)c2ccc(F)cc2)c1C(=O)OC,[Pd],CO,,,,val
US06399773B1,COc1cc([N+](=O)[O-])ccc1Cl.c1nc[nH]n1>>COc1cc([N+](=O)[O-])ccc1-n1cncn1,,CS(C)=O,,[K+].[OH-],,val
US20130116289A1,CCN[C@H](CC(C)C)C(=O)OC(C)(C)C.N#Cc1cc(F)cc(CBr)c1>>CC(C)CC(NCc1cc(F)cc(C#N)c1)C(=O)OC(C)(C)C,,CN(C)C=O,O,Cl,O=C([O-])O.[Na+],val
US20130116249A1,C/C(N)=N\O.COC(=O)Cn1c(=O)[nH]c2ccc(C(=O)c3c(C)c(OC)c4ccccn34)cc2c1=O>>COc1c(C)c(C(=O)c2ccc3[nH]c(=O)n(Cc4nc(C)no4)c(=O)c3c2)n2ccccc12,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120196884A1,Nc1ccc([N+](=O)[O-])cn1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1ccc([N+](=O)[O-])cn1,,Cc1ccccc1,,,,val
US20080221197A1,CCOC(=O)C(C)Cl.CI.O=[N+]([O-])c1ccccc1>>CCOC(=O)C(C)(C)c1ccc([N+](=O)[O-])cc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20110245205A1,Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C(N[S@](=O)C(C)(C)C)(C3CC3)C3CC3)s2)c1>>Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C(N)(C3CC3)C3CC3)s2)c1,,CO,,Cl,,val
US20050124555A1,Brc1cc(Cc2cc3cccccc-3c2)ccc1OCc1ccccc1.O=C1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1>>OC1(c2cc(Cc3cc4cccccc-4c3)ccc2OCc2ccccc2)O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US04568670,CCSC(=N)N(C)C.COP(=O)(Cl)SC>>CCSC(=NP(=O)(OC)SC)N(C)C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05723467,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2.O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O>>Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2.O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O,,CCO,CN(C)C=O,,,val
US09365514B2,CC(C)(C)OC(=O)N1CCC(Oc2ccc3c(c2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)CC1>>CC1(C)c2cc(C3CCNCC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21,,C1CCOC1,,O=C(O)C(F)(F)F,,val
US20080070912A1,CC(C)C(=O)c1c(C(C)C)nn2ccccc12>>CC(C)c1nn2ccccc2c1C(O)C(C)C,,CO,,[BH4-].[Na+],,val
US20060276508A1,CCOc1cc(C=O)ccc1F.c1c[nH]cn1>>CCOc1cc(C=O)ccc1-n1ccnc1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090137564A1,CC(C)N=C=O.Oc1ccc(Cl)cc1F>>CC(C)NC(=O)Oc1ccc(Cl)cc1F,CN(C)c1ccncc1,C1CCOC1,,Cl,,val
US20100210619A1,CC(C)CN.O=C1CCCC1>>CC(C)CNC1CCCC1,,CCO,,[BH4-].[Na+],,val
US04338314,Cl.Cl.ClCCN1CCN2c3ccc(Cl)cc3C(c3ccccc3)=NCC2C1.O>>Cl.Cl.OCCN1CCN2c3ccc(Cl)cc3C(c3ccccc3)=NCC2C1,,CC(C)O,,ClC(Cl)Cl,,val
US20080214520A1,CC(C)(CNc1c(Cl)ccc2c1CCN(C(=O)C(F)(F)F)CC2)COC1CCCCO1>>CC(C)(CO)CNc1c(Cl)ccc2c1CCN(C(=O)C(F)(F)F)CC2,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US05623073,COc1ccc(C(=O)CN2C3=NCCN3c3ccccc32)cc1.Cl>>COc1ccc(C(O)CN2C3=NCCN3c3ccccc32)cc1.Cl,,CO,,[BH4-].[Na+],,val
US20120178934A1,CC#CCOc1ccc(C(=O)NCC(C(=O)NOC(C)(C)C)N2CCN(S(C)(=O)=O)CC2)cc1>>CC#CCOc1ccc(C(=O)NCC(C(=O)NO)N2CCN(S(C)(=O)=O)CC2)cc1,,O=C(O)C(F)(F)F,,,,val
US20090247577A1,CC(C)(C)OC(=O)N1CC(Cc2cc(F)cc(F)c2)C(CN(Cc2ccncc2)C(=O)C2CC(=O)Nc3ccccc32)C1>>O=C1CC(C(=O)N(Cc2ccncc2)CC2CNCC2Cc2cc(F)cc(F)c2)c2ccccc2N1,,O,,CC#N,CC#N,val
US20080269192A1,CC(C)(C)[Si](C)(C)OC[C@H](COCc1ccccc1)Nc1c(N)cnc2ccccc12.CCOC(=N)CCl>>CC(C)(C)[Si](C)(C)OC[C@H](COCc1ccccc1)n1c(CCl)nc2cnc3ccccc3c21,,ClCCCl,,Cl,O=C([O-])O.[Na+],val
US20150196546A1,N#CCC#N.N#CCC(N)=S.O=Cc1c(F)cccc1F>>N#CC1=C(N)SC(N)=C(C#N)C1c1c(F)cccc1F,,CCO,O,C1CCNCC1,,val
US20150191472A1,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O[C@@H]1[C@@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)N(C(=O)OC(C)(C)C)[C@@H](c2c[nH]c3c(N)ncnc23)[C@@H]1O.CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O[C@@H]1[C@H](O)[C@@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)N(C(=O)OC(C)(C)C)[C@H]1c1c[nH]c2c(N)ncnc12>>CC(C)[C@H](N)C(=O)O[C@@H]1[C@@H](CO)N[C@@H](c2c[nH]c3c(N)ncnc23)[C@@H]1O.CC(C)[C@H](N)C(=O)O[C@@H]1[C@H](O)[C@@H](CO)N[C@H]1c1c[nH]c2c(N)ncnc12,,CC(C)=O,,O=S(=O)(O)O,,val
US20090111810A1,Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)O.OCCN1CCOCC1>>Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)OCCN1CCOCC1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150329549A1,CCOC(=O)c1nnn2c1CCCc1cc(OC(F)(F)F)ccc1-2>>O=C(O)c1nnn2c1CCCc1cc(OC(F)(F)F)ccc1-2,,C1CCOC1,CO,[Na+].[OH-],,val
US20100239576A1,CS(=O)(=O)Cl.O=C(OC1(CCO)CC1)c1ccccc1>>CS(=O)(=O)OCCC1(OC(=O)c2ccccc2)CC1,,ClCCl,,,,val
US06204293B1,COC(=O)c1ccc(CCl)cc1-c1ccccc1C.OCc1ccc(-c2ccccc2)o1>>COC(=O)c1ccc(COCc2ccc(-c3ccccc3)o2)cc1-c1ccccc1C,,CCOC(C)=O,CN(C)C=O,C1COCCOCCOCCOCCO1,[H-].[Na+],val
US20040024057A1,COc1ccc2cc([C@H](C)C(=O)O)ccc2c1.O=C(CO)CO>>COc1ccc2cc([C@H](C)C(=O)OCC(=O)CO)ccc2c1,,CC(C)=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100105655A1,C1COCCN1.COc1cc(C(C)C(=O)O)ccc1N>>COc1cc(C(C)C(=O)N2CCOCC2)ccc1N,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130053409A1,COc1cc(N2CC[C@@H](N(C)C)C2)c([N+](=O)[O-])cc1Nc1nccc(-c2cnn3c2CCCC3)n1>>COc1cc(N2CC[C@@H](N(C)C)C2)c(N)cc1Nc1nccc(-c2cnn3c2CCCC3)n1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20070173508A1,CCC(=O)C(F)(F)F.Sc1nccs1>>CCC(O)(c1cnc(S)s1)C(F)(F)F,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20100305122A1,CI.NS(=O)(=O)c1ccc(NCC2CNCCO2)c([N+](=O)[O-])c1>>CN1CCOC(CNc2ccc(S(N)(=O)=O)cc2[N+](=O)[O-])C1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20050261333A1,C1COCCN1.COc1c(Cl)cnc2[nH]c(-c3ccc(OCCCl)cc3)nc12>>COc1c(Cl)cnc2[nH]c(-c3ccc(OCCN4CCOCC4)cc3)nc12,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20090264650A1,COC(=O)C1CC(=O)N(C2CCCCC2)C1>>O=C1CC(CO)CN1C1CCCCC1,,O,,CCO,[BH4-].[Na+],val
US20090318442A1,COc1cccc2c(=O)[nH]c3scnc3c12>>O=c1[nH]c2scnc2c2c(O)cccc12,,ClCCl,,BrB(Br)Br,,val
US20070225332A1,CC(C)O.Oc1ccc(Oc2nccs2)c(Cl)c1>>CC(C)Oc1ccc(Oc2nccs2)c(Cl)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110020447A1,CC(=O)Cl.CNC(=O)c1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)nc1>>CNC(=O)c1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)nc1.Cl,,CO,,CCOC(C)=O,,val
US20080090854A1,CCOC(=O)c1cc(F)ccc1S.COC(=O)C(C)(C)NC(=O)CCl>>COC(=O)C(C)(C)NC(=O)c1sc2ccc(F)cc2c1O,,CO,,C[O-].[Na+],,val
US20100239526A1,CC(C)(C)OC(=O)NCc1cccc(-c2n[nH]c3ncc4c(c23)CCN(C(=O)OC(C)(C)C)C4)c1.O=C(O)C(F)(F)F>>NCc1cccc(-c2n[nH]c3ncc4c(c23)CCNC4)c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20160272628A1,CC(C)(C)OC(=O)CBr.CC1c2cc(-c3c[nH]c4cc(F)ccc34)ccc2S(=O)(=O)N1C1CCNC(=O)C1.CN(C)C=O.O=C([O-])[O-]>>CC(C)(C)OC(=O)CN1C(CO)c2cc(-c3cn(C(=O)OC(C)(C)C)c4cc(F)ccc34)ccc2S1(=O)=O,,CN(C)C=O,,O,,val
US20040029888A1,CN(C)CCOc1ccccc1OCc1ccccc1.O=C1OCCO1>>CN(C)CCOc1ccccc1OCCO,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20140243391A1,CCCCCCCCCCCCO.O=C1CCC(=O)O1>>CCCCCCCCCCCCOC(=O)CCC(=O)O,CN(C)c1ccncc1,Cc1ccccc1,,,,val
US05994355,COC(CNC(=O)N(N=Cc1ccccc1)c1cc(Cl)c(C(C#N)c2ccc(Cl)cc2)c(Cl)c1)OC>>N#CC(c1ccc(Cl)cc1)c1c(Cl)cc(N2N=CCNC2=O)cc1Cl,,CC#N,,Cl,,val
US20130303375A1,N#Cc1ccc(Cl)nc1.O=C1CC2Cc3ccccc3C2N1>>N#Cc1ccc(N2C(=O)CC3Cc4ccccc4C32)nc1,,Cc1ccccc1,,[H-].[Na+],,val
US04156693,BrCCCBr.CNCCC[N+](C)(C)C.[Br-]>>CN(CCCBr)CCC[N+](C)(C)C.[Br-],,CC#N,,,,val
US20150210698A1,CN1CCN([C@@H]2CC[C@@H](n3cc(-c4ccc(N)cc4)c4c(N)ncnc43)CC2)CC1.Cn1c(C(=O)O)cc2ccccc21>>CN1CCN([C@@H]2CC[C@@H](n3cc(-c4ccc(NC(=O)c5cc6ccccc6n5C)cc4)c4c(N)ncnc43)CC2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120219495A1,CC(C)(C)OC(=O)CN1CCCN2CCN(CC(=O)OC(C)(C)C)CCCN(CC1)CC(Cc1ccc([N+](=O)[O-])cc1)C2>>CC(C)(C)OC(=O)CN1CCCN2CCN(CC(=O)OC(C)(C)C)CCCN(CC1)CC(Cc1ccc(N)cc1)C2,[Pd],CCO,,,,val
US20160009645A1,Cl.O=C(Cl)C1CCC1.c1cc(OC2CCNCC2)ccc1OCCCN1CCCCC1>>Cl.O=C(C1CCC1)N1CCC(Oc2ccc(OCCCN3CCCCC3)cc2)CC1,,CCN(CC)CC,,Cl,ClCCl,val
US20050009928A1,CCCCCC1CCC(=C2CCCC2)C1=O>>CCCCCC1CCC(C2CCCC2)C1=O,[Pd],CCO,,,,val
US20100130545A1,CNCCC1(O)CC2CCC1C=C2c1ccccc1.COCC(C)(COC)C(=O)NCCC=O>>COCC(C)(COC)C(=O)NCCCN(C)CC[C@]1(O)C[C@H]2CC[C@@H]1C=C2c1ccccc1,,CC(=O)O,ClCCl,[BH3-]C#N.[Na+],,val
US20110021352A1,O=C1CC(=O)C2C=CC1O2>>O=C1CC(=O)C2CCC1O2,[Pd],CCO,,,,val
US20090005363A1,C1CCNCC1.O=C(O)c1ccc(Nc2ccc(Cl)cc2)nn1>>O=C(c1ccc(Nc2ccc(Cl)cc2)nn1)N1CCCCC1,,CC(=O)N(C)C,CCOC(C)=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04939133,COc1ccc(CCc2ccc(N)cc2)cc1OC.O=CO>>COc1ccc(CCc2ccc(NC=O)cc2)cc1OC,,Cc1ccccc1,,,,val
US20040157890A1,CCOC(=O)CBr.Cc1cc(CO)cc(C)c1O>>CCOC(=O)COc1c(C)cc(CO)cc1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100286390A1,COCOCC1C(N2C(=O)c3ccccc3C2=O)CC2CC1C2(C)C>>CC1(C)C2CC(N3C(=O)c4ccccc4C3=O)C(CO)C1C2,,CO,Cl,,,val
US20110166128A1,CCCCCCO.O=C(Cl)OCCl>>CCCCCCOC(=O)OCCl,,ClCCl,,Cl,c1ccncc1,val
US20150111885A1,BrBr.Cn1ccc2cc(F)ccc2c1=O>>Cn1cc(Br)c2cc(F)ccc2c1=O,,CC(=O)O,,,,val
US20090048259A1,C[C@@H]1CNCCN1c1nnc(Cl)c2ccccc12.O=C(Cl)c1ccccc1>>C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(Cl)c2ccccc12,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20150376179A1,CC(C)(C)OC(=O)N1CCC(OS(C)(=O)=O)CC1.COC(=O)c1cc[nH]n1>>COC(=O)c1ccnn1C1CCN(C(=O)OC(C)(C)C)CC1,,CN1CCCC1=O,,[H-].[Na+],,val
US20120283249A1,COc1ccc(NC(=O)CNC(=O)OC(C)(C)C)cc1>>COc1ccc(NC(=O)CN)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20070249670A1,COC(=O)[C@H](COC1CCOCC1)NC(=O)c1cc2ccccc2cc1N.Cc1cc(C)c(N=C=O)c(C)c1>>COC(=O)[C@H](COC1CCOCC1)NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C,,c1ccncc1,,,,val
US20100179124A1,C=CC(=O)OCC.NCC1CN(S(=O)(=O)c2c(Nc3ccc(I)cc3F)sc3ncccc23)C1>>CCOC(=O)CCNCC1CN(S(=O)(=O)c2c(Nc3ccc(I)cc3F)sc3ncccc23)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20060178418A1,COc1ccc(C(=O)Nc2ccncc2)c2c1oc1ccccc12.O=C(OO)c1cccc(Cl)c1>>COc1ccc(C(=O)[NH2+][O-])c2c1oc1ccccc12,,ClC(Cl)Cl,,,,val
US20070149562A1,Cl.O=C([C@@H](Cc1ccc(Cl)cc1)NC1CCN(c2ccccn2)CC1)N1CCC(Cn2cncn2)(C2CCCCC2)CC1>>Cl.O=C([C@@H](Cc1ccc(Cl)cc1)NC1CCN(c2ccccn2)CC1)N1CCC(Cn2cncn2)(C2CCCCC2)CC1,,CCOCC,ClCCl,,,val
US04798738,CC(=O)OC(C)=O.O=S(=O)([O-])c1c(S(=O)(=O)[O-])c2ccc3cccc4cc(O)c(c1S(=O)(=O)[O-])c2c34.[Na+].[Na+].[Na+]>>CC(=O)Oc1cc2cccc3ccc4c(S(=O)(=O)[O-])c(S(=O)(=O)[O-])c(S(=O)(=O)[O-])c1c4c32.[Na+].[Na+].[Na+],,CN(C)C=O,,CC(=O)[O-].[Na+],,val
US20030078251A1,CCOC(=O)CCc1cccc(NC(=O)C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)COC(C)=O)C2=O)c1>>COc1cccc([C@H]2O[C@H](CC(=O)Nc3cccc(CCC(=O)O)c3)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,O,,CCO,[Na+].[OH-],val
US20080009530A1,CCOC(=O)CCc1cc(OC(C)C)nn1Cc1ccc(C(F)(F)F)cc1Cl>>CC(C)Oc1cc(CCC(=O)O)n(Cc2ccc(C(F)(F)F)cc2Cl)n1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US05436224,C=NC(C)(C)c1cccc(Cl)c1.CC1=C(CC(C)C)C(=O)OC(C)(C)O1>>CC1=C(CC(C)C)C(=O)N(C(C)(C)c2cccc(Cl)c2)CO1,,Cc1ccccc1C,,,,val
US20150051199A1,Br[Mg]c1ccccc1.Cc1ccc(Cl)c(C(=O)Cl)c1F>>Cc1ccc(Cl)c(C(=O)c2ccccc2)c1F,,C1CCOC1,,CCCCP(CCCC)CCCC,,val
US20150093655A1,CC[N+](C)(C)CCCO.O=S(=O)([N-]S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC[N+](C)(C)CC(C)O.O=S(=O)([N-]S(=O)(=O)C(F)(F)F)C(F)(F)F,,O,,[Cl-].[Li+],,val
US05635510,CO.Cl.O=C(O)C1(c2ccccc2)CCNCC1>>COC(=O)C1(c2ccccc2)CCNCC1.Cl,,CCOCC,,O=S(Cl)Cl,,val
US20150353553A1,CC(C)C(O)c1ccccn1>>CC(C)=Cc1ccccn1,,C1CCOC1,,O=S(Cl)Cl,,val
US20120142706A1,COC(=O)c1ccc([N+](=O)[O-])cc1C.O=C1CCC(=O)N1Br>>CN1Cc2cc([N+](=O)[O-])ccc2C1=O,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20160016946A1,C1COCCN1.CC(C)(C)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1-c1ccc(CBr)cn1>>CC(C)(C)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1-c1ccc(CN2CCOCC2)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130331349A1,CO.O=C(O)c1cc2ccc(O)nn2c1>>COC(=O)c1cc2ccc(O)nn2c1,O=S(=O)(O)O,,,,,val
US20040106791A1,C=CCc1cnc2c(c1)C(=O)N(C)c1cccnc1N2CC.O=O>>CCN1c2ncc(CCO)cc2C(=O)N(C)c2cccnc21,,CO,ClCCl,[BH4-].[Na+],[Cl-].[NH4+],val
US20150299192A1,CI.O=C1NCCc2[nH]c(I)cc21>>Cn1c(I)cc2c1CCNC2=O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110136780A1,CC(C)[C@H](C(=O)O)N1Cc2c(F)cnc3[nH]cc(c23)C1=O.NC1CCS(=O)(=O)C1>>CC(C)[C@H](C(=O)NC1CCS(=O)(=O)C1)N1Cc2c(F)cnc3[nH]cc(c23)C1=O,CN(C)c1ccncc1,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20150126484A1,N#Cc1c(N)ncnc1N1CCC(N)(CNC(=O)c2ccc(F)cc2F)C1.OO>>NC(=O)c1c(N)ncnc1N1CCC(N)(CNC(=O)c2ccc(F)cc2F)C1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05219863,CCc1cc(OCc2ccc(-c3ccccc3-c3nnn(C(c4ccccc4)(c4ccccc4)c4ccccc4)n3)cc2)c2nc(OCCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)ccc2n1>>c1cnc2cccnc2c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140364432A1,COc1ccc(CN2CCCC(C)C2C(N)=O)cc1>>COc1ccc(CN2CCC[C@@H](C)[C@H]2CN)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040147543A1,NCC1CCCCC1.O=[N+]([O-])c1cnc2cc(Br)ccc2c1Cl>>O=[N+]([O-])c1cnc2cc(Br)ccc2c1NCC1CCCCC1,,ClCCl,,,,val
US20060199956A1,COP(=O)(OC)c1cc(F)ccc1CNC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>COP(=O)(OC)c1cc(F)ccc1CN.O=C(O)C(F)(F)F,,ClCCl,,,,val
US03943154,CC(C)c1cc(C(C)C)c(S(=O)(=O)Cl)c(C(C)C)c1.N#CC=CS(=O)(=O)c1ccc(N)cc1>>CC(C)c1cc(C(C)C)c(S(=O)(=O)Nc2ccc(S(=O)(=O)C=CC#N)cc2)c(C(C)C)c1,,C1COCCO1,,c1ccncc1,,val
US20140057937A1,Cc1cc(C(F)(F)F)n[nH]1.O=C(CCl)N1CCCc2c1cnn2-c1ccc(F)cc1>>Cc1cc(C(F)(F)F)nn1CC(=O)N1CCCc2c1cnn2-c1ccc(F)cc1,,C1CCOC1,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130281490A1,CC(C)(C)[C@@H](O)[C@H](N)C(=O)O.O=C([O-])n1cccc(CCCCCc2ccccc2)c1=O>>CC(C)(C)[C@H](O)[C@@H](NC(=O)OCCCCCc1ccccc1)C(=O)O,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20100029606A1,BrCC1CC1.COC(=O)c1ccc(O)cc1>>COC(=O)c1ccc(OCC2CC2)cc1,,CC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20070021473A1,CCN.CCOC(=O)c1ccc(-c2ccc(OCCCI)c(-c3ccc4c(c3)C(C)(C)CCC4(C)C)c2)cc1>>CCNCCCOc1ccc(-c2ccc(C(=O)OCC)cc2)cc1-c1ccc2c(c1)C(C)(C)CCC2(C)C,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20030040513A1,O=C(O)c1ccccc1C(=O)c1ccc(Cl)c([N+](=O)[O-])c1.O=C1OCc2ccccc2N1C1CCNCC1>>O=C(O)c1ccccc1C(=O)c1ccc(N2CCC(N3C(=O)OCc4ccccc43)CC2)c([N+](=O)[O-])c1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20100216814A1,CC(=CBr)c1ccncc1.Cc1ccc2[nH]c3c(c2c1)CN(CCCO)CC3>>C/C(=C\n1c2c(c3cc(C)ccc31)CN(CCCO)CC2)c1ccncc1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20150266879A1,CC(C)(C)OC(=O)N1c2ncccc2CC1C(=O)Nc1c(F)cccc1F>>O=C(Nc1c(F)cccc1F)C1Cc2cccnc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030055265A1,C=CCCO.O=C(O)CBr>>C=CCCOCC(=O)O,,C1CCOC1,,[H-].[Na+],,val
US04399141,O=c1c2ccccc2cc(N2CCCCC2)c2ccccc12.[Li]C>>CC1(O)c2ccccc2C=C(N2CCCCC2)c2ccccc21,,C1CCOC1,CCOCC,,,val
US20090209607A1,Cn1nccc1-c1ccc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)s1>>Cn1nccc1-c1ccc(C(=O)NC(CN)Cc2ccccc2C(F)(F)F)s1,,C1CCOC1,CO,NN,,val
US05504082,Cc1c(SCCCN)ccnc1CSc1nc2ccccc2[nH]1.OCCBr>>Cc1c(SCCCNCCO)ccnc1CSc1nc2ccccc2[nH]1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070254866A1,CN(CCN)c1ccccn1.COc1c(F)c(F)c(N)c2c(=O)c(C(=O)O)cn(C3CC3)c12>>COc1c(NCCN(C)c2ccccn2)c(F)c(N)c2c(=O)c(C(=O)O)cn(C3CC3)c12,,CS(C)=O,,CCN(CC)CC,,val
US20080312227A1,CC(C)Oc1nc(N)nc2ncc(Br)cc12.COc1ccc(B(O)O)cc1OC>>COc1ccc(-c2cnc3nc(N)nc(OC(C)C)c3c2)cc1OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090306063A1,CC[C@@H](c1ccccc1)N1Cc2cc3c(cc2C[C@H]1C(=O)O[C@@H]1C[C@H](C)CC[C@H]1C(C)C)N(C)C(=O)[C@@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)O3>>CC[C@@H](c1ccccc1)N1Cc2cc3c(cc2C[C@H]1C(=O)O)N(C)C(=O)[C@@H](c1ccc(O)cc1)O3,,CCCCCC,ClCCl,ClB(Cl)Cl,,val
US20100130497A1,CC#CCBr.COc1cc(C=O)ccc1O>>CC#CCOc1cc(C=O)ccc1OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080287394A1,CCOC(=O)c1c(OC)c2n(c1C#N)[C@@H](C)CN(CC)C2=O.NN>>CCN1C[C@H](C)n2c(c(OC)c3c(=O)[nH]nc(N)c32)C1=O,CC(=O)O,CCO,,,,val
US20100273764A1,Cc1nc(N)cc(Cl)n1.OB(O)c1cccnc1F>>Cc1nc(N)cc(-c2cccnc2F)n1,,C1COCCO1,O,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20140336185A1,CCCCCCCOc1ccc(C(=O)Oc2ccc(CN(CC(=O)OC(C)(C)C)C(=O)c3ccc(NC(=O)Cc4ccc(OC)cc4C(F)(F)F)cn3)cc2)cc1>>CCCCCCCOc1ccc(C(=O)Oc2ccc(CN(CC(=O)O)C(=O)c3ccc(NC(=O)Cc4ccc(OC)cc4C(F)(F)F)cn3)cc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140018319A1,CC(C)(C)OC(=O)N1CCC(O)C1.N#Cc1cc(O)c(Cl)c([N+](=O)[O-])c1>>CC(C)(C)OC(=O)N1CCC(Oc2cc(C#N)cc([N+](=O)[O-])c2Cl)C1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090326003A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1ccc(-c2ccc(C(=O)NCc3c(CC)nc4c(cnn4CC)c3NC3CCOCC3)cc2)cc1.O=C(O)c1ccc(C(=O)O)c(C(=O)O)c1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1ccc(-c2ccc(C(=O)NCc3c(CC)nc4c(cnn4CC)c3NC3CCOCC3)cc2)cc1.O=C(O)c1ccc(C(=O)O)c(C(=O)O)c1,,CO,,,,val
US20050176789A1,CN.O=C(Nc1ncc(Cc2ccccc2Cl)s1)C(Br)c1ccccc1>>CNC(C(=O)Nc1ncc(Cc2ccccc2Cl)s1)c1ccccc1,,CN(C)C=O,,,,val
US20130184257A1,CS(=O)(=O)c1cc(F)c(N[C@H]2CCN(C3CCN(C#N)CC3)C2=O)c(F)c1.NO>>CS(=O)(=O)c1cc(F)c(N[C@H]2CCN(C3CCN(C(=N)NO)CC3)C2=O)c(F)c1,,CCO,,,,val
US20020019527A1,N#Cc1ccc(C(O)c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1-c1cccc2ccccc12.N#Cc1ccc(CBr)cc1>>N#Cc1ccc(COC(c2ccc(C#N)c(-c3cccc4ccccc34)c2)c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1,O=[Ag-],ClCCl,,,,val
US20080261969A1,CC(C)(C)[Si](C)(C)Oc1ccc2[nH]c(Sc3ccc(C=O)o3)nc2c1.CCOC(=O)c1[nH]ccc1N.O=C1CCCC(=O)C1>>CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3cc(O[Si](C)(C)C(C)(C)C)ccc3[nH]2)o1,,CCCCO,,,,val
US20130143870A1,CC(=O)NC1CN(C(=O)OCc2ccccc2)CC1O>>CC(=O)NC1CN(C(=O)OCc2ccccc2)CC1=O,,CS(C)=O,ClCCl,CCN(C(C)C)C(C)C,O,val
US20090131467A1,COc1ccccc1CC(=O)c1c(O)c2cccnc2n(-c2cccc(C(F)(F)F)c2)c1=O.NN>>COc1ccccc1Cc1n[nH]c2c1c(=O)n(-c1cccc(C(F)(F)F)c1)c1ncccc21,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20130116243A1,CC1Oc2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc2NC1=O.N#CCBr>>CC1Oc2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc2N(CC#N)C1=O,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04092150,CC(C)Nc1nc(Cl)c(C#N)c(NC2CC2)n1.CO>>COc1nc(NC(C)C)nc(NC2CC2)c1C#N,,CO,,C[O-].[Na+],,val
US20030220324A1,COC(=O)c1ccccc1N1CCN(Cc2ccccc2)CC1>>COC(=O)c1ccccc1N1CCNCC1,[Pd],,,,,val
US20090030195A1,CN(CC(=O)O)C(=O)OC(C)(C)C.O=C1O[C@@H](CO)CN1c1ccc2cc(-c3ccccc3C(F)(F)F)[nH]c(=O)c2c1>>CN(CC(=O)OC[C@H]1CN(c2ccc3cc(-c4ccccc4C(F)(F)F)[nH]c(=O)c3c2)C(=O)O1)C(=O)OC(C)(C)C,,ClCCl,,,,val
US20020004522A1,N#Cc1ccccc1C=Cc1ccc(F)cc1>>N#Cc1ccccc1CCc1ccc(F)cc1,[Pd],COCCOC,O,,,val
US05663448,CC(=O)O.CC(C)(C)c1ccc(N)cc1>>CC(=O)Nc1ccc(C(C)(C)C)cc1,[Zn],,,,,val
US20060247262A1,C1=COCCC1.CC(C)(C)C(=O)Nc1cccc(O)c1>>CC(C)(C)C(=O)Nc1cccc(OC2CCCCO2)c1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20140148452A1,COc1cccc(O)c1.OC[C@@H]1CN(CCN2CCc3ccccc32)CCO1>>COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030087930A1,CCOC(=O)C(N)C(=O)OCC.O=C(Cl)c1ccc(Cl)cc1>>CCOC(=O)C(NC(=O)c1ccc(Cl)cc1)C(=O)OCC,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US20020032208A1,COc1cc(CCl)cc(Cl)n1.COc1cc2c(Oc3ccccc3)ncnc2cc1O>>COc1cc(COc2cc3ncnc(Oc4ccccc4)c3cc2OC)cc(Cl)n1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20160122359A1,CC(C)(C)OC(=O)N1CCCC12CN([C@@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)C(N)=O)C2=O>>CC(C)(C)OC(=O)N1CCCC12CN([C@@H](CO)C(N)=O)C2=O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050261358A1,CC(N)Cc1c[nH]c2ccccc12.CN(C)C1(c2ccccc2)CCC(N)CC1.S=C(Cl)Cl>>CC(Cc1c[nH]c2ccccc12)NC(=S)NC1CCC(c2ccccc2)(N(C)C)CC1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US06265446B1,CCN(CC)CCCS(=O)(=O)N(CC(C)C)NC(=O)[C@H](CC(C)C)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1.Cc1ccc(S(=O)(=O)O)cc1>>CCN(CC)CCCS(=O)(=O)N(CC(C)C)NC(=O)[C@H](CC(C)C)[C@H](C/C=C/c1ccccc1)C(=O)NO.Cc1ccc(S(=O)(=O)O)cc1,,CO,,O,,val
US20150274747A1,CN(c1ccnc(Cl)n1)C1COC2C(O)COC21.Cn1cc(N)cn1>>CN(c1ccnc(Nc2cnn(C)c2)n1)C1COC2C(O)COC21,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20040019232A1,CCCCCCCCCCCCCCCCOCCCO.Nc1ncnc2c1ncn2CCOCP(=O)(O)O>>CCCCCCCCCCCCCCCCOCCCOP(=O)(O)COCCn1cnc2c(N)ncnc21,,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130023566A1,NC(c1ccc(F)cc1)c1ccc(F)cc1.O=Cc1ccccc1-c1noc2cc(Br)ccc12>>Fc1ccc(C(/N=C/c2ccccc2-c2noc3cc(Br)ccc23)c2ccc(F)cc2)cc1,,ClCCl,,O=S(=O)([O-])[O-].[Mg+2],,val
US20070093521A1,Brc1cccc2nc(NC3CCNCC3)oc12.CCOc1cc(C=O)cc(OCC)c1-n1cccc1>>CCOc1cc(CN2CCC(Nc3nc4cccc(Br)c4o3)CC2)cc(OCC)c1-n1cccc1,,CC(=O)O,CCO,CCN(C(C)C)C(C)C,[BH3-]C#N.[Na+],val
US20100239576A1,COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)OC(=O)[C@H](C)N)n(-c5ccccc5)c4=O)cc3F)ccnc2c1.O=P(O)(O)O>>COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)OC(=O)[C@H](C)N)n(-c5ccccc5)c4=O)cc3F)ccnc2c1.O=P(O)(O)O,,CCOC(C)=O,,CO,,val
US04933458,CN(C)c1ccccc1CSc1cnc2ccccc2n1.O=C(OO)c1cccc(Cl)c1>>CN(C)c1ccccc1CS(=O)c1cnc2ccccc2n1,,ClC(Cl)Cl,,,,val
US05633379,CC(C)(C)OC(=O)CS.CCOC(C)=O.COC(=O)C(Br)CCc1ccccc1>>CCOC(=O)C(CCc1ccccc1)SCC(=O)OC(C)(C)C,,CCOC(C)=O,,C1CCOC1,[H-].[Na+],val
US20060172973A1,NC(=O)CCC(=O)NBr.c1ccc(Cn2cnc3cncnc32)cc1>>Brc1nc2cncnc2n1Cc1ccccc1,,ClC(Cl)Cl,,,,val
US06194454B1,CCOC(=O)C(=O)Nc1cc(C)c(Oc2ccc(O)c(C(C)C)c2)c(C#N)c1>>Cc1cc(NC(=O)C(=O)O)cc(C#N)c1Oc1ccc(O)c(C(C)C)c1,,CCO,,[Na+].[OH-],,val
US06140031,ICCCCI.O=S1(=O)CCN(c2ccc(O)cc2)CC1>>O=S1(=O)CCN(c2ccc(OCCCCI)cc2)CC1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070003539A1,COC(=O)C[C@@H](C(=O)OC(C)(C)C)c1cc([N+](=O)[O-])ccc1SC(C)C.COC(=O)Cl>>COC(=O)C[C@@H](C(=O)OC(C)(C)C)c1cc(C(=O)OC)ccc1SC(C)C,[Pd],CCOC(C)=O,CO,[H][H],,val
US20080058302A1,C1COCCN1.CNc1ccc(C(=O)O)cc1S(=O)(=O)Cl>>CNc1ccc(C(=O)O)cc1S(=O)(=O)C1CNCCO1,,CCOC(C)=O,,,,val
US20140080829A1,C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@@H](c4ccc(Cl)cc4)[C@@H]4CCCN4)CC3)c21.O=S(=O)(OCCC(F)(F)F)C(F)(F)F>>C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@@H](c4ccc(Cl)cc4)[C@@H]4CCCN4CC(F)(F)F)CC3)c21,CN(C)c1ccncc1,CC(C)=O,,CCN(C(C)C)C(C)C,,val
US20110021434A1,COC(=O)[C@@H]1CCCCOc2ccc(cc2)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1.Cl>>COC(=O)[C@@H]1CCCCOc2ccc(cc2)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N1.Cl,,C1COCCO1,,,,val
US20100311965A1,Cc1cccc2cnc(Cl)nc12.Nc1ccc2cn[nH]c2c1>>Cc1cccc2cnc(Nc3ccc4cn[nH]c4c3)nc12,,CCCCO,,Cl,,val
US05958924,CO.Cn1c(=O)cc(CC(=O)O)c2cc(F)ccc21>>COC(=O)Cc1cc(=O)n(C)c2ccc(F)cc12,,ClCCl,,O=S(Cl)Cl,,val
US20110269780A1,CCCC(Cn1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2cccnc21)C(=O)OCC>>CCCC(Cn1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2cccnc21)C(=O)O,,C1COCCO1,O,[Li+].[OH-],,val
US04188396,CC(=O)c1ccc(C2CCN(C(C)=O)CC2)c([N+](=O)[O-])c1>>CC(=O)c1ccc(C2CCN(C(C)=O)CC2)c(N)c1,[Pd],CCO,,[H][H],,val
US20090054428A1,CO.Cc1ccc(C)nc1.O=[Se]=O>>COC(=O)c1ccc(C)cn1,,CO,c1ccncc1,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US06124287,NNc1nc2ccccc2n2ccnc12>>Nc1nc2ccccc2n2ccnc12,[Ni],O,,,,val
US20130096133A1,C1CNCCN1.FC(F)(F)c1ccc(CCl)cc1>>FC(F)(F)c1ccc(CN2CCNCC2)cc1,,C1CCOC1,,,,val
US20090318468A1,COC(=O)c1ccc(N2CCN(C)[C@H](C)C2)cc1.COc1cc(CCc2cc(N)[nH]n2)cc(OC)c1>>COc1cc(CCc2cc(NC(=O)c3ccc(N4CCN(C)[C@H](C)C4)cc3)[nH]n2)cc(OC)c1,,CO,Cc1ccccc1,C[Al](C)C,Cl,val
US20130143870A1,Brc1ccccc1.O=CC1=C(Cl)CCN(Cc2ccccc2)CC1>>OC(C1=C(Cl)CCN(Cc2ccccc2)CC1)c1ccccc1,,CCOCC,,II,[Mg],val
US20080004300A1,CC(C)(C)OC(=O)N1CCC(CBr)CC1.CC1(C)CNc2cc([N+](=O)[O-])ccc21>>CC(C)(C)OC(=O)N1CCC(CN2CC(C)(C)c3ccc([N+](=O)[O-])cc32)CC1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20090186879A1,CCC(CC(N)=O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl>>CCC(CC#N)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US05116530,CCCCCCCCCCCCc1cccs1.CN(C)C=O>>CCCCCCCCCCCCc1ccc(C=O)s1,,O,,O=P(Cl)(Cl)Cl,,val
US20050239981A1,CCOP(=O)(OCC)C1=Cc2ccccc2C1>>PC1=Cc2ccccc2C1,,CCOCC,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20080045521A1,COC(=O)[C@H](Cc1ccc(N2CC(Cc3cccc(N(C)C(=O)OC(C)(C)C)n3)C2)cc1)NC(=O)c1c(Cl)cccc1Cl>>CNc1cccc(CC2CN(c3ccc(C[C@H](NC(=O)c4c(Cl)cccc4Cl)C(=O)OC)cc3)C2)n1,,O=C(O)C(F)(F)F,,,,val
US20120129842A1,CC(=O)c1sc(C)nc1C.CI>>CCC(=O)c1sc(C)nc1C,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20070191604A1,C=CCBr.COC(=O)C1CCN(C(=O)OC(C)(C)C)C1>>C=CCC1(C(=O)OC)CCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20020006943A1,BrCCC1OCCO1.CON(C)C(=O)CCC(F)(F)F>>O=C(CCC1OCCO1)CCC(F)(F)F,,C1CCOC1,,[Cl-].[NH4+],,val
US20090281079A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.COCc1c(-c2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)c(F)c2)c2c(N)ncnn2c1Br>>COCc1c(-c2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)c(F)c2)c2c(N)ncnn2c1C1=CCN(C(=O)OC(C)(C)C)CC1,,C1COCCO1,,N#N,O=C([O-])[O-].[Na+].[Na+],val
US06498172B1,CC(C)(C)OC(=O)COc1cccc(CN)c1.O=Cc1ccc(-c2ccncc2)cc1>>CC(C)(C)OC(=O)COc1cccc(CNCc2ccc(-c3ccncc3)cc2)c1,,CCN(CC)CC,,,,val
US04855084,CCOC(=O)CCCCCCCCCc1ccccc1.O=C1OC(=O)c2ccccc21>>CCOC(=O)CCCCCCCCCc1ccc(C(=O)c2ccccc2C(=O)O)cc1,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100029611A1,COC(=O)CBr.c1ccc(C2(c3ccc4nc(-c5ccc6c(c5)CNC6)sc4n3)CC2)cc1>>COC(=O)CN1Cc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)cc2C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100273775A1,CSc1nccc(C#Cc2ccc(F)cc2)n1.Oc1on[n+]2c1C=COC2>>CSc1nccc(-c2c(-c3ccc(F)cc3)nn3c2CCOC3)n1,,Cc1cc(C)cc(C)c1,,,,val
US20050049245A1,CNCC(O)c1cc2ccccc2n1C.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)sc21>>CN(Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2s1)CC(O)c1cc2ccccc2n1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US04331676,CC(=O)S[C@@H]1CC(=O)N1C(Cl)C(=O)OCc1ccc([N+](=O)[O-])cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=O)S[C@@H]1CC(=O)N1C(C(=O)OCc1ccc([N+](=O)[O-])cc1)=P(c1ccccc1)(c1ccccc1)c1ccccc1,,C1COCCO1,,,,val
US04670447,CN1CCC(c2n[nH]c3cc(Cl)ccc23)CC1.O=C(Cl)c1ccccc1>>CN1CCC(c2nn(C(=O)c3ccccc3)c3cc(Cl)ccc23)CC1.Cl,,CCOCC,,,,val
US05138069,CCCCc1nc(Cl)c(COC)n1Cc1ccc(-c2ccccc2CC#N)cc1.c1nnn[nH]1>>CCCCc1nc(Cl)c(COC)n1Cc1ccc(-c2ccccc2Cc2nnn[nH]2)cc1,,CC(C)O,CCOC(C)=O,CCCCCC,,val
US20060094767A1,CC(C)(C)OC(=O)N1CCN(CC2(C)Cn3cc([N+](=O)[O-])nc3O2)CC1.CC(C)N=C=O>>CC(C)NC(=O)N1CCN(CC2(C)Cn3cc([N+](=O)[O-])nc3O2)CC1,,O,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US07053105B2,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(Cl)cc(-c3cccc(Cl)c3)c2c1>>C=C(OCC)c1cc(-c2cccc(Cl)c2)c2cc(C(O)(c3ccc(Cl)cc3)c3cncn3C)ccc2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,CCOC(C)=O,,val
US20060257987A1,CCc1ccc(OCCC(CC)Oc2ccc(CCC(=O)OC)c(C)c2)c(C(=O)c2ccccc2)c1>>CCc1ccc(OCCC(CC)Oc2ccc(CCC(=O)O)c(C)c2)c(C(=O)c2ccccc2)c1,,CCO,,[Na+].[OH-],,val
US20130324573A1,O=C=Nc1ccc(F)cc1.Oc1ccc2c(c1)N(Cc1ccccc1)CCC2>>O=C(Nc1ccc(F)cc1)Oc1ccc2c(c1)N(Cc1ccccc1)CCC2,,C1CCOC1,,CCN(CC)CC,,val
US20100087427A1,CCc1ccc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2N)C(C)C)cc1OCCCOC.O=S(=O)(Cl)Cc1ccc(F)cc1>>CCc1ccc(C(=O)N(C[C@@H]2CNC[C@H]2NS(=O)(=O)Cc2ccc(F)cc2)C(C)C)cc1OCCCOC,,O,,CC#N,CC#N,val
US20140162985A1,O=C1C=C2CCCc3nc4c(cnn4-c4ccc(F)cc4)cc3C2(Cc2ccccn2)CC1>>O=C1CCC2(Cc3ccccn3)c3cc4cnn(-c5ccc(F)cc5)c4nc3CCCC2C1,[Pd],C1CCOC1,c1ccncc1,[H][H],,val
US20160229815A1,COC(=O)c1ccc2nc(Cl)c(N(C)C(C)C)nc2c1.OB(O)c1ccc(F)c(F)c1>>COC(=O)c1ccc2nc(-c3ccc(F)c(F)c3)c(N(C)C(C)C)nc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20100130546A1,CC(=O)OC(C)=O.NCCCOc1ccc(F)cc1[N+](=O)[O-]>>CC(=O)NCCCOc1ccc(F)cc1[N+](=O)[O-],,ClCCl,O,Cl,c1ccncc1,val
US05142056,C1COCCN1.C=CC(=O)OC>>COC(=O)CCN1CCOCC1,,ClCCl,,,,val
US07495007B2,C=C(C)C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=C(C)C1N(C(=O)OC(C)(C)C)C(=O)CC(c2cccc(Cl)c2)C12C(=O)N(C(=O)OC(C)(C)C)c1cc(Cl)ccc12,CN(C)c1ccncc1,ClCCl,,,,val
US20150353553A1,CC(C)(C)[Si](C)(C)Cl.OCCC[C@@H](Nc1nc(Cl)nc2ncn(Cc3ccc(C(F)(F)F)cc3)c12)C1CCC1>>CC(C)(C)[Si](C)(C)OCCC[C@@H](Nc1nc(Cl)nc2ncn(Cc3ccc(C(F)(F)F)cc3)c12)C1CCC1,,ClCCl,,c1c[nH]cn1,,val
US20150315141A1,CC(=O)O.NC(=O)C1(O)CCCc2cnccc21>>O=C(O)C1(O)CCCc2cnccc21,,Cl,,,,val
US20150315114A1,CC(C)(C)[Si](C)(C)OC[C@H](O)CCC#C[Si](C)(C)C>>C#CCC[C@@H](O)CO[Si](C)(C)C(C)(C)C,,CCO,,[K+].[OH-],,val
US20060135556A1,Cc1ccc2c(C)ccc([N+](=O)[O-])c2n1>>Cc1ccc2c(C)ccc(N)c2n1,[Ni],CCO,,,,val
US20130165440A1,CN1CC=C(c2cc([N+](=O)[O-])cc(C(F)(F)F)c2)CC1>>CN1CCC(c2cc(N)cc(C(F)(F)F)c2)CC1,[Pd],CCO,,,,val
US04593118,CC(=O)NC(C(=O)O)C(C)NCc1ccccc1>>CC(NCc1ccccc1)C(N)C(=O)O,,Cl,,,,val
US20130217679A1,O=C1CCCc2[nH]ccc21>>C1=CCC2CCNC2=C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080096877A1,CCN=C=NCCCN(C)C.CN(c1cc(OC(F)(F)F)cc2cc(C3=NCC(CC(=O)O)S3)[nH]c12)S(=O)(=O)c1cccs1>>CN(c1cc(OC(F)(F)F)cc2cc(C3=NCC(CC(N)=O)S3)[nH]c12)S(=O)(=O)c1cccs1,,O,,CN(C)C=O,Cl,val
US20110110889A1,COCc1cc2cc([N+](=O)[O-])cnc2n1S(=O)(=O)c1ccccc1>>COCc1cc2cc([N+](=O)[O-])cnc2[nH]1,,CO,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20100063081A1,CC(C)(C)OC(=O)N1CCC(CC=O)CC1.CCOP(=O)(CP(=O)(OCC)OCC)OCC>>CCOP(=O)(/C=C/CC1CCN(C(=O)OC(C)(C)C)CC1)OCC,,ClCCl,O,[Na+].[OH-],,val
US20160052884A1,CC(C)(C)OC(=O)c1ccc(N)cc1.COc1cn(C(CC2(C)CC2)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N>>COc1cn(C(CC2(C)CC2)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N,,CN(C)C=O,,CC(C)N=C=NC(C)C,,val
US20110160243A1,CCOC(=O)CCCn1c(C(=O)OCC)cc2cc(OCc3ccccc3)ccc21>>CCOC(=O)C1=C(O)c2cc3cc(OCc4ccccc4)ccc3n2CC1,,C1CCOC1,,Cl,CC(C)(C)[O-].[K+],val
US05240942,COc1ccc2c(c1)C(O)(C1CCN(C)CC1)CCC2>>COc1ccc2c(c1)C(C1CCN(C)CC1)=CCC2,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04877444,CCI.O=C1COc2cc(F)c(-n3nc4c(c3Cl)CCCC4)cc2N1>>CCN1C(=O)COc2cc(F)c(-n3nc4c(c3Cl)CCCC4)cc21,,CN(C)C=O,,O,[H-].[Na+],val
US06057369,C=C(C(=O)OC(C)(C)C)C(O)CCCCc1ccccc1.O=C(O)c1ccccc1>>CC(C)(C)OC(=O)/C(=C/CCCCc1ccccc1)COC(=O)c1ccccc1,,C1CCOC1,CCOCC,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090286974A1,COC(=O)Cc1cccc(CBr)c1.O=[N+]([O-])c1ccccc1S(=O)(=O)NC1CCN(c2nc3ccc(Cl)cc3s2)C1>>COC(=O)Cc1cccc(CN(C2CCN(c3nc4ccc(Cl)cc4s3)C2)S(=O)(=O)c2ccccc2[N+](=O)[O-])c1,,CN(C)C=O,,O,[H-].[Na+],val
US20080269196A1,CN(C)C(=O)Sc1ccc(CNc2c(Cl)ccc3c2CCN(C(=O)OC(C)(C)C)CC3)cc1.COC(=O)CBr>>COC(=O)CSc1ccc(CNc2c(Cl)ccc3c2CCN(C(=O)OC(C)(C)C)CC3)cc1,,CCOC(C)=O,CO,[K+].[OH-],,val
US04804668,CCOC(=O)Cl.COC1(OC)SC=C(C)NC1=O.c1cscn1>>CCOC(=O)N1C=CSC1C1=C(C)N=CC(OC)(OC)S1,,ClCCl,,,,val
US20100216795A1,COCCO.O=[N+]([O-])c1ccc(F)cc1>>COCCOc1ccc([N+](=O)[O-])cc1,,CS(C)=O,O,[K+].[OH-],,val
US20140010783A1,CS/C(=N\C#N)Nc1cccc(S(C)(=O)=O)c1.NN>>CS(=O)(=O)c1cccc(Nc2n[nH]c(N)n2)c1,,CCO,,,,val
US20100121048A1,CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)C(CO)C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)C(COS(C)(=O)=O)C1,,ClCCl,,CCN(CC)CC,,val
US20080200475A1,CCc1cc2c(N3CCN(C(=O)c4ccc(-c5ccccc5)cc4)CC3)nc(NC(=O)[C@@H]3CCCN3C(=O)OC(C)(C)C)nc2s1>>CCc1cc2c(N3CCN(C(=O)c4ccc(-c5ccccc5)cc4)CC3)nc(NC(=O)[C@@H]3CCCN3)nc2s1,,Cc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,val
US20090098086A1,Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCN(CC(F)(F)F)CC4)c3n2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCO>>O=C(Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCN(CC(F)(F)F)CC4)c3n2)cc1)OCCO,,C1CCOC1,,CCN(CC)CC,,val
US20040138269A1,CCOC(=O)c1[nH]c(C)c(-c2ccc(C(=O)O)cc2)c1C.Nc1ccc(Br)cc1>>CCOC(=O)c1[nH]c(C)c(-c2ccc(C(=O)Nc3ccc(Br)cc3)cc2)c1C,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,O=C([O-])O.[Na+],val
US20110152322A1,CCOC(=O)C(C#N)=C(Cl)c1cccnc1Cl.NCCc1ncc(C(F)(F)F)cc1Cl>>CCOC(=O)/C(C#N)=C(\NCCc1ncc(C(F)(F)F)cc1Cl)c1cccnc1Cl,,C1CCOC1,,CCN(CC)CC,Cl,val
US20120010182A1,CC(C)(C)OC(=O)N1CC(NN)C1.COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3ccc(-c4ccccc4C(F)(F)F)cc3C(=O)/C=C/N(C)C)cc2F)c(OC)c1>>COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3ccc(-c4ccccc4C(F)(F)F)cc3-c3ccnn3C3CN(C(=O)OC(C)(C)C)C3)cc2F)c(OC)c1,,CC(=O)O,CCO,O=C([O-])O.[Na+],,val
US20110229568A1,C=[N+]=[N-].CC(C)(C)OC(=O)N[C@@H](CCC(=O)O)C(=O)OC(C)(C)C>>COC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C,,CO,,,,val
US20130184253A1,CCn1nc(C2CC2)c(Cl)c1N1CCc2nc(-c3c(C)ccc4c3c(C)nn4S(=O)(=O)c3ccc(C)cc3)nc(N3CCOC[C@H]3C)c2C1>>CCn1nc(C2CC2)c(Cl)c1N1CCc2nc(-c3c(C)ccc4[nH]nc(C)c34)nc(N3CCOC[C@H]3C)c2C1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US05661161,CC/C=C/C=O.CCOC(=O)C(NC(C)=O)C(=O)OCC>>CCOC(=O)C1(C(=O)OCC)C(CC)CC(O)N1C(C)=O,,CCO,,[Na],,val
US20120264749A1,Cc1cc(C(=O)N2CCC3(CC2)CN(Cc2ccccc2)CC(c2ccccc2)O3)ccc1OC(C)C>>Cc1cc(C(=O)N2CCC3(CC2)CNCC(c2ccccc2)O3)ccc1OC(C)C,[Pd],CO,,O=C[O-].[NH4+],,val
US20090105258A1,COC(=O)C=Cc1ccc(C(C)(C)C)cc1OC1CCOCC1>>CC(C)(C)c1ccc(C=CC(=O)O)c(OC2CCOCC2)c1,,CO,O,Cl,[Na+].[OH-],val
US20130336920A1,COC(=O)c1cccc2[nH]ccc12.O=C(NCc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(N3CCCCC3)ccc2NC(=O)c2cccc(CCl)c2)c1>>O=C(NCc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(N3CCCCC3)ccc2NC(=O)c2cccc(Cn3ccc4c(C(=O)O)cccc43)c2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100048556A1,CCOC(=O)CCc1nccn1-c1ccc(F)cc1[N+](=O)[O-]>>CCOC(=O)CCc1nccn1-c1ccc(F)cc1N,,CC(=O)O,O,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20100069362A1,CC(=O)N(C)N(C(=O)OC(C)(C)C)c1ccc(CCn2cnc3cc(-c4ccc(Cl)cc4)sc3c2=O)cc1>>CC(=O)N(C)Nc1ccc(CCn2cnc3cc(-c4ccc(Cl)cc4)sc3c2=O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150225389A1,C[C@@H](NC(=O)N1C(=O)[C@H](Cc2ccnc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c2)[C@H]1Oc1ccc(C(=O)O)cc1)c1ccccc1.O=C(O)C(F)(F)F>>C[C@@H](NC(=O)N1C(=O)[C@H](Cc2ccnc(N)c2)[C@H]1Oc1ccc(C(=O)O)cc1)c1ccccc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20120165310A1,C1CNC1.Nc1ncnc2c1c(-c1cccc(OCC34CCC(CC3)O4)c1)cn2C1CC(C=O)C1>>Nc1ncnc2c1c(-c1cccc(OCC34CCC(CC3)O4)c1)cn2C1CC(CN2CCC2)C1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04165378,CI.CNC(=S)NCCSCc1csc(NC(=N)N)n1.O=C(O)/C=C\C(=O)O>>CN=C(NCCSCc1csc(NC(=N)N)n1)SC.I.O=C(O)/C=C\C(=O)O,,CCO,,,,val
US20090054502A1,CCCCC(CC)C(=O)[O-].Cc1oc(=O)oc1COC(=O)c1cccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c12.[K+]>>Cc1oc(=O)oc1COC(=O)c1cccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4noc(C(=O)[O-])n4)cc3)c12.[K+],,CC(C)=O,,,,val
US20030166628A1,C1=C(c2cc3ccccc3s2)N2CCN=C2S1.CSSC>>CSC1=C(c2cc3ccccc3s2)N2CCN=C2S1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US05474998,CCOP(=O)(OCC)N1CC2(C(=O)OC)COc3cc(C(F)(F)F)ccc3C2=N1.Cl>>COC(=O)C12CNN=C1c1ccc(C(F)(F)F)cc1OC2.Cl,,CO,,,,val
US20070161685A1,C=C(C)OC(=O)Cl.COc1ccc(C(N)(Cc2ccccc2)c2cc(F)cc(C(F)(F)F)c2)nc1>>C=C(C)OC(=O)NC(Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(OC)cn1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20090023716A1,CC1(C)Oc2cc(N)ccc2N(c2ccccc2)C1=O.CS(=O)(=O)Cl>>CC1(C)Oc2cc(NS(C)(=O)=O)ccc2N(c2ccccc2)C1=O,,ClC(Cl)Cl,,c1ccncc1,O=C([O-])O.[Na+],val
US04299821,C[C@@H](OCc1ccccc1)[C@H](NC(=O)[C@@H]1CCC(=O)N1C(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O>>C[C@@H](O)[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(N)=O,[Pd],CC(=O)O,,,,val
US05202356,CCCCOC(=O)[C@H]1[C@H](c2cccc(C(F)(F)F)c2)C1(C)C>>CC1(C)[C@@H](c2cccc(C(F)(F)F)c2)[C@@H]1CO,,ClCCl,,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US20070027187A1,NCCOc1ccc(F)cc1.O=C(Nc1cccc2c1CC(O)CC2)Oc1ccccc1>>O=C(NCCOc1ccc(F)cc1)Nc1cccc2c1CC(O)CC2,,CS(C)=O,,O,,val
US20140163010A1,Clc1ncnc2[nH]ncc12.OCCN1CCCCC1>>Clc1ncnc2c1cnn2CCN1CCCCC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150322075A1,O.OCCCN(c1cc(Cl)nc(Cl)n1)C1CC1>>O=c1nc(Cl)cc(N(CCCO)C2CC2)[nH]1,,C1COCCO1,O,[Na+].[OH-],,val
US20120071512A1,Br[Mg]C1CC1.O=Cc1cncc(Br)c1>>OC(c1cncc(Br)c1)C1CC1,,C1CCOC1,,,,val
US20070244159A1,CCOC(=O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1/C=C/N(C)C>>CCOC(=O)c1cc(N)cc2[nH]ccc12,,CCO,,Cl[Sn]Cl,,val
US20100190766A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[Si](C)(C)C#Cc1ccc(CNC2CC2)cc1>>CC(C)(C)OC(=O)N(Cc1ccc(C#C[Si](C)(C)C)cc1)C1CC1,,ClCCl,,CCN(CC)CC,,val
US20080275029A1,CC(C)(C)OC(=O)N1CCC(C=O)(c2ccc(Cl)cc2)CC1>>CC(C)(C)OC(=O)N1CCC(CO)(c2ccc(Cl)cc2)CC1,,CCO,CO,[BH4-].[Na+],,val
US20090099156A1,CCN1CCN(C(=O)OCc2ccccc2)C(CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1>>CCN1CCNC(CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1,,C1COCCO1,,Cl,,val
US20130123252A1,COC(=O)c1sc(C#CC(C)(C)C)cc1Br.O=C1NC(C2CCCCC2)COC1CCCO>>COC(=O)c1sc(C#CC(C)(C)C)cc1N1C(=O)[C@@H](CCCO)OCC1C1CCCCC1,[Cu]I,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20150018345A1,NCCN.O=C(Cl)OCc1ccccc1>>NCCNC(=O)OCc1ccccc1,,ClCCl,,,,val
US20040152699A1,C[C@@H](Cl)C(=O)O.Cn1c(S)nnc1-c1cccs1>>CC(Sc1nnc(-c2cccs2)n1C)C(=O)O,,CC#N,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20150158868A1,Cc1ccc(S(N)(=O)=O)cc1.FC(F)(F)c1ccc(Cl)nn1>>Cc1ccc(S(=O)(=O)Nc2ccc(C(F)(F)F)nn2)cc1,,CS(C)=O,,[H-].[Na+],,val
US04877804,CCOc1nnc(C(C)Br)s1.Oc1ccc(Oc2ccccn2)cc1>>CCOc1nnc(C(C)Oc2ccc(Oc3ccccn3)cc2)s1,,CN(C)C=O,O,[I-].[K+],,val
US20120238452A1,CCOC(=O)Cl.Cc1cc(C)c(C2C(=O)N(N(C)C)C3(CCN(N(C)C)CC3)C2=O)c(C)c1>>CCOC(=O)OC1=C(c2c(C)cc(C)cc2C)C(=O)N(N(C)C)C12CCN(N(C)C)CC2,,C1CCOC1,,CCN(CC)CC,,val
US20100009957A1,O=C(N[C@H]1CN(Cc2ccccc2)CCN(Cc2ccccc2)C1=O)OCc1ccccc1>>N[C@H]1CN(Cc2ccccc2)CCN(Cc2ccccc2)C1=O,,CC#N,,Br,,val
US20140005191A1,CC(=O)OC[C@H]1O[C@@H]2SC(N3CCC3)=N[C@@H]2[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>OC[C@H]1O[C@@H]2SC(N3CCC3)=N[C@@H]2[C@@H](O)[C@@H]1O,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20110046137A1,Cc1nn(CC(C)(C)O)c(C)c1C(C(=O)[O-])C(C)(C)C>>Cc1nn(CC(C)(C)O)c(C)c1CC(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US06262040B1,CCc1nn(C2CCCC2)c2cc(C(=O)NCC(=O)NOCc3ccccc3)ccc12>>CCc1nn(C2CCCC2)c2cc(C(=O)NCC(=O)NO)ccc12,[Pd],CO,,CCOC(C)=O,O,val
US05728712,COC(=O)C1Cc2ccccc2CN1S(=O)(=O)c1ccc(OC)c(OC)c1>>COc1ccc(S(=O)(=O)N2Cc3ccccc3CC2C(=O)O)cc1OC,,C1CCOC1,,[Li+].[OH-],,val
US20110257137A1,CC(C)(C)OC(=O)N1CCN(c2nc3ccc(C#N)cc3n3nnnc23)CC1.O=C(O)C(F)(F)F>>N#Cc1ccc2c(c1)-n1nnnc1C(N1CCNCC1)N2.O=C(O)C(F)(F)F,,ClCCl,,CO,,val
US20110098430A1,C=C(c1ccccc1)c1cccc(-c2cccc(-c3ccccc3)c2OCc2ccc(F)cc2)n1>>CC(c1ccccc1)c1cccc(-c2cccc(-c3ccccc3)c2O)n1,[Pd],CCO,,,,val
US20130225679A1,CN(C)CC1CCC2CC2C1(O)c1cccc(O)c1.C[Si](C)(C)Cl>>CN(C)CC1CCC2CC2C1(O)c1cccc(O)c1.Cl,,CCC(C)=O,,O,,val
US20110059948A1,CC(=O)c1cc(F)ccc1Oc1nc2ccc(-n3cc(-c4ccccc4)nn3)cc2cc1Cc1ccccc1>>CC(O)c1cc(F)ccc1Oc1nc2ccc(-n3cc(-c4ccccc4)nn3)cc2cc1Cc1ccccc1,,C1CCOC1,CCO,[BH4-].[Na+],,val
US20120214803A1,Cc1c(F)cccc1S(=O)(=O)Cl.Nc1cccc2cccnc12>>Cc1c(F)cccc1S(=O)(=O)Nc1cccc2cccnc12,CN(C)c1ccncc1,,,,,val
US04788206,CCCCC/C(=C/C=O)c1cccc(F)c1.COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCC/C(=C/C=C/C(=O)OC)c1cccc(F)c1,,ClCCl,,,,val
US20150252038A1,CC(C)(C)OC(=O)N1CC(F)(COc2cc(F)c(C(=O)O)cc2Cl)C1.CCI>>CCOC(=O)c1cc(Cl)c(OCC2(F)CN(C(=O)OC(C)(C)C)C2)cc1F,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20030212276A1,COCCO.COc1cc2c(Nc3cc(OC)c(OC)c(OC)c3)c(C#N)cnc2cc1F>>COCCOc1cc2ncc(C#N)c(Nc3cc(OC)c(OC)c(OC)c3)c2cc1OC,,COCCO,,[H-].[Na+],,val
US20160122344A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCC(F)(F)F)cc1CC2C(C)(C)COC>>COCC(C)(C)C1Cc2cc(OCC(F)(F)F)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21,,C1CCOC1,CCO,Cl,[Li+].[OH-],val
US06303614B1,BrCc1ccccc1.CCOC(=O)N1CCc2[nH]c3ccc(OCc4ccccc4)cc3c2C1>>CCOC(=O)N1CCc2c(c3cc(OCc4ccccc4)ccc3n2Cc2ccccc2)C1,,CN(C)C=O,,O,[H-].[Na+],val
US20070161685A1,N[C@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1.O=C(OC(=O)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)F>>O=C(N[C@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1)C(F)(F)C(F)(F)F,c1ccncc1,ClCCl,,,,val
US05439917,CSSC.Cc1[nH]c2nc(Br)ccc2c1C>>CSc1ccc2c(C)c(C)[nH]c2n1,,C1CCOC1,O,CCCCCC,[Li]CCCC,val
US20140142105A1,CC(C)(C)OC(=O)N1CC[C@@H](NS(=O)(=O)c2ccc(-c3noc(C(F)(F)F)n3)cc2)C1>>O=S(=O)(N[C@@H]1CCNC1)c1ccc(-c2noc(C(F)(F)F)n2)cc1,,Cl,,C1COCCO1,,val
US20160264552A1,C1CCNC1.N#Cc1cnc(N[C@@H]2CCN(C(=O)c3ccc(N)cc3)C2)nc1-c1c[nH]c2ccccc12.O=C(Cl)/C=C/CBr>>N#Cc1cnc(N[C@@H]2CCN(C(=O)c3ccc(NC(=O)/C=C/CN4CCCC4)cc3)C2)nc1-c1c[nH]c2ccccc12,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20060252768A1,CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)C[C@H]1c1ccc(Cl)cc1.CC(Cl)OC(=O)Cl.ClCCCl>>Cl.Cl.Clc1ccc([C@@H]2CNCCN2)cc1,,ClCCCl,,,,val
US20140128637A1,COc1cc(C)c(-c2cccc3cccc(-c4cc(-c5ccccc5)c(OC)cc4C)c23)cc1-c1ccccc1>>Cc1cc(O)c(-c2ccccc2)cc1-c1cccc2cccc(-c3cc(-c4ccccc4)c(O)cc3C)c12,,ClCCl,,BrB(Br)Br,,val
US20070213331A1,CCCN(C)C(=O)c1cc(CO)cc(C(=O)OCC)c1.CI>>CCCN(C)C(=O)c1cc(COC)cc(C(=O)OCC)c1,,C1CCOC1,,[H-].[Na+],,val
US20160229809A1,COC(=O)c1cc2ccsc2[nH]1>>Cc1cc2ccsc2[nH]1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090163464A1,CI.Sc1nc2ccc(I)cc2s1>>CSc1nc2ccc(I)cc2s1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20150031679A1,COC(=O)c1ccc2nc(Cl)c(N(C)C(C)C)nc2c1.COc1ccc(B(O)O)cc1>>COC(=O)c1ccc2nc(-c3ccc(OC)cc3)c(N(C)C(C)C)nc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20080015227A1,COC(=O)C1CCCCC1C(=O)c1ccc(-c2ccc([N+](=O)[O-])cc2)cc1>>COC(=O)C1CCCCC1C(=O)c1ccc(-c2ccc(N)cc2)cc1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20150051199A1,CC[C@@H](NC(=O)OC(C)(C)C)c1ccc(Cl)c(C(=O)c2ccc(Cl)nc2)c1F.c1cn[nH]c1>>CC[C@@H](N)c1ccc(Cl)c(C(=O)c2ccc(-n3cccn3)nc2)c1F,,CN(C)C=O,,[H-].[Na+],,val
US20040208782A1,CCCCCCCCO.CCOCC.OCC(O)CCl>>CCCCCCCCOCC(O)CO.CCOCC,,CCOCC,,[Na],,val
US20100081718A1,CCCC[C@@H](C)C[C@H](N)CC(=O)O.CCCC[C@@H](C)C[C@H](N)CC(=O)OC(C)(C)C>>CCCC[C@@H](C)C[C@@H](CC(=O)OC(C)(C)C)C(=O)O,,Cl,,,,val
US06022870,CNN.Nc1ccccc1Oc1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN(N)C(=O)Nc1ccccc1Oc1ccccc1,,ClCCCl,,CCN(CC)CC,,val
US20120295884A1,CC(C)(C)OC(=O)N1C[C@@](F)(CN)C[C@H]1C(=O)OCc1ccccc1.CC(C)(C)OC(=O)N1C[C@@](F)(CNC(=O)OCC(Cl)(Cl)Cl)C[C@H]1C(=O)OCc1ccccc1.CI.O=C(Cl)OCC(Cl)(Cl)Cl>>CN(C[C@@]1(F)C[C@@H](C(=O)NCc2cccc(Cl)c2F)N(C(=O)OC(C)(C)C)C1)C(=O)OCC(Cl)(Cl)Cl,,ClCCl,,CN(C)C=O,[H-].[Na+],val
US20140100231A1,COc1ccc(Cn2nc(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc(OC(F)F)c2=O)cc1>>COc1ccc(Cn2nc(CO)cc(OC(F)F)c2=O)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090227588A1,Nc1cnc(Br)cn1.O=C(Cl)C1CCCCC1>>O=C(Nc1cnc(Br)cn1)C1CCCCC1,,C1CCOC1,,CCN(C(C)C)C(C)C,[Cl-].[NH4+],val
US05587392,Nc1cc(Oc2ccc(Cl)cc2Cn2cncn2)ccc1[N+](=O)[O-]>>Nc1ccc(Oc2ccc(Cl)cc2Cn2cncn2)cc1N,[Zn],CC(=O)O,,,,val
US20140275071A1,COCCOCCO.CS(=O)(=O)Cl>>COCCOCCOS(C)(=O)=O,,ClCCl,,,,val
US04559354,CC(=O)c1nc(-c2ccc(O)cc2)n(C)c1C.ClCC1CO1>>CC(=O)c1nc(-c2ccc(OCC3CO3)cc2)n(C)c1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150252034A1,COc1ccc(CN(c2cccc(F)n2)S(=O)(=O)c2cc3oc(=O)n([C@H](C)c4ccccc4C4(O)CN(C(=O)OC(C)(C)C)C4)c3cc2F)c(OC)c1>>C[C@H](c1ccccc1C1(O)CNC1)n1c(=O)oc2cc(S(=O)(=O)Nc3cccc(F)n3)c(F)cc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020119963A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=[N+]([O-])c1cn(C2CC(O)C2)cn1>>Cc1ccc(S(=O)(=O)O[C@@H]2C[C@@H](n3cnc([N+](=O)[O-])c3)C2)cc1,,ClCCl,,CCN(CC)CC,,val
US20080214545A1,COCCNS(=O)(=O)c1cccc(-n2nc(C(C)(C)C)cc2N)c1.O=C(Cl)Oc1ccccc1>>COCCNS(=O)(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Oc2ccccc2)c1,,C1CCOC1,,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20100267688A1,N#CC1CCC2(CC1)OCCO2.NO>>N=C(NO)C1CCC2(CC1)OCCO2,,CCO,,,,val
US20100004238A1,CI.O=C1NCc2cc(Oc3ccc([N+](=O)[O-])cc3Cl)ccc21>>CN1Cc2cc(Oc3ccc([N+](=O)[O-])cc3Cl)ccc2C1=O,,CN(C)C=O,,O,[H-].[Na+],val
US20130237537A1,CN1CCC(Oc2ccc(N)cc2)CC1.Nc1ncc2c(n1)CCN(c1cccc(C(=O)O)c1)C2>>CN1CCC(Oc2ccc(NC(=O)c3cccc(N4CCc5nc(N)ncc5C4)c3)cc2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100029737A1,COC(=O)c1cc2c([nH]1)C(Cc1cccc(OC)c1)CC2>>COC(=O)c1cc2c([nH]1)C(Cc1cccc(O)c1)CC2,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US05030652,O=C(O)Cc1ccc2c(c1)CC(NS(=O)(=O)c1ccc(Cl)cc1)C2>>O=S(=O)(NC1Cc2ccc(CCO)cc2C1)c1ccc(Cl)cc1,,C1CCOC1,,CO,,val
US03932663,CC(=O)OC(C)=O.NCC=C(c1ccc(-c2ccccc2)cc1)c1ccc(-c2ccccc2)cc1>>CC(=O)NCC=C(c1ccc(-c2ccccc2)cc1)c1ccc(-c2ccccc2)cc1,,CC(=O)O,,,,val
US20100113528A1,CC(C)Oc1ccc(C(=O)O)cc1Cl.CCOC(=O)C(C)(C)Cn1ncc2c(C(=N)NO)cccc21>>CCOC(=O)C(C)(C)Cn1ncc2c(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)cccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040235919A1,COC(=O)C(C)c1ccc(N)cc1.O=C=NCCCl>>COC(=O)C(C)c1ccc(NC(=O)NCCCl)cc1,,ClCCl,,,,val
US20150291554A1,COC(=C(C#N)C#N)c1ccc(I)cc1.NNC1CCCN(C(=O)OCc2ccccc2)C1>>N#Cc1c(-c2ccc(I)cc2)nn(C2CCCN(C(=O)OCc3ccccc3)C2)c1N,,CCO,,CCN(CC)CC,Cl,val
US20090197908A1,C1CCOC1.CI.CS(=O)(=O)Nc1ccc2c(c1)C(O)c1cc(-c3ccccc3)cnc1C=C2>>COC1c2cc(N(C)S(C)(=O)=O)ccc2C=Cc2ncc(-c3ccccc3)cc21,,CCOC(C)=O,,O,[H-].[Na+],val
US20080051586A1,CCOC(=O)Cn1c(C)c(Sc2ccc(Cl)cc2)c2c(NC(C)=O)cccc21>>CC(=O)Nc1cccc2c1c(Sc1ccc(Cl)cc1)c(C)n2CC(=O)O,,CCCO,,[Na+].[OH-],,val
US20110028469A1,COC(=O)c1sccc1N.O=S(=O)(Cl)c1ccccc1Cl>>COC(=O)c1sccc1NS(=O)(=O)c1ccccc1Cl,,ClCCl,,c1ccncc1,,val
US20050197346A1,Cc1nc2cc(OC[C@H](O)CN3CCC(=O)CC3)ccc2s1.N[C@@H]1CCN(c2ccc(Cl)cc2)C1=O>>Cc1nc2cc(OC[C@H](O)CN3CCC(N[C@@H]4CCN(c5ccc(Cl)cc5)C4=O)CC3)ccc2s1,,CCO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040167123A1,NCc1csc2c1S(=O)(=O)N=C(c1c(O)c3ccccc3n(Cc3ccccc3)c1=O)N2.O=C(Cl)N1CCOCC1>>O=C(NCc1csc2c1S(=O)(=O)N=C(c1c(O)c3ccccc3n(Cc3ccccc3)c1=O)N2)N1CCOCC1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20080045556A1,COC(C)(C)OC.O=C(CO)Nc1nc(-c2ccc(Br)cc2)cs1>>CC1(C)OCC(=O)N1c1nc(-c2ccc(Br)cc2)cs1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20110034436A1,CCOC(=O)C(=CNC1(CO)CC1)C(=O)c1cc(F)c(F)c(F)c1F>>CCOC(=O)c1cn2c3c(c(F)c(F)cc3c1=O)OCC21CC1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050049252A1,CCOC(=O)C1=C(C(F)(F)F)COc2ccc3ccccc3c21>>O=C(O)C1=C(C(F)(F)F)COc2ccc3ccccc3c21,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20100311747A1,CN(C)C(=O)N1CC2CC(C#N)CC2C1.IC1CCCC1>>CN(C)C(=O)N1CC2CC(C#N)(C3CCCC3)CC2C1,,CN(C)C=O,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20160102085A1,CC#N.CC(C)(C#N)C#N>>CC(C)(C#N)C(N)=CC#N,,Cc1ccccc1,,O,,val
US20040063937A1,CC1COC(=O)N1c1cc(-c2ccnc(Nc3cccc(Cl)c3)n2)ccn1.COCCl>>COCN(c1cccc(Cl)c1)c1nccc(-c2ccnc(N3C(=O)OCC3C)c2)n1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20110237620A1,NCc1cccc(C(F)(F)F)c1.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)sc3n2)ccc1F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(NCc1cccc(C(F)(F)F)c1)Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)sc3n2)ccc1F,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20160039804A1,CCNC1CCCCC1.O=CC1(Br)C=NC(Br)=CN1>>CCN(c1ncc(Br)nc1C=O)C1CCCCC1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20070196852A1,Cc1ccc(C(=O)OCC2OC(Cl)CC2OC(=O)c2ccc(C)cc2)cc1.O=[N+]([O-])c1ccc2[nH]cc(I)c2c1>>Cc1ccc(C(=O)OCC2OC(n3cc(I)c4cc([N+](=O)[O-])ccc43)CC2OC(=O)c2ccc(C)cc2)cc1,,CC#N,,[H-].[Na+],,val
US20030109459A1,COC(=O)[C@@H](N)Cc1ccc([N+](=O)[O-])cc1.O=C(O)C1(Cc2ccccc2)CCCC1>>COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1(Cc2ccccc2)CCCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US03975535,CCO.COc1ccc(C=O)c(C(=O)O)c1>>COc1ccc2cc(C(=O)O)oc(=O)c2c1,,CCO,,,,val
US20050282826A1,CCOC(=N)C(O)c1ccc(F)c(Br)c1.NCCCN>>OC(c1ccc(F)c(Br)c1)C1NC=CCN1,,CCO,,Cl,,val
US20110312904A1,C=C[Mg]Br.CCCCCCC[C@H]1OC(C)(C)O[C@@H]1Cc1ccc(C=O)cc1>>C=CC(O)c1ccc(C[C@H]2OC(C)(C)O[C@@H]2CCCCCCC)cc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20090176786A1,CN(C(=O)Cl)c1ccc(SC(F)(F)F)cc1F.NC1CC1>>CN(C(=O)NC1CC1)c1ccc(SC(F)(F)F)cc1F,,COC(C)(C)C,,CCN(CC)CC,,val
US20090298883A1,CCN=C=O.NC1(CN2CCC(CNC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)CCCC1>>CCNC(=O)NC1(CN2CCC(CNC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)CCCC1,,CCOC(C)=O,ClCCl,,,val
US20130116243A1,CN1c2cc(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)nc2OCS1(=O)=O>>CN1c2cc(-c3ccccc3)c(-c3ccc(C4(N)CCC4)cc3)nc2OCS1(=O)=O,,O=C(O)C(F)(F)F,,,,val
US20110092505A1,CCOC(=O)c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1-c1ccnc(NC2CCCCC2)c1>>CCOC(=O)c1ccc(N2CCNCC2)nc1-c1ccnc(NC2CCCCC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150342931A1,CON(C)C(=O)C1(NC(=O)OCc2ccccc2)CCC1.FC(F)(F)c1cc([Mg]Br)cc(C(F)(F)F)c1>>O=C(NC1(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC1)OCc1ccccc1,,C1CCOC1,,,,val
US20080021032A1,CC(C)(C)OC(=O)Cn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)n1>>CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(CC(=O)O)n2)cc1Cl,,ClCCl,O=C(O)C(F)(F)F,,,val
US20150175594A1,Nc1sc2c(c1-c1nc(C3CC3)no1)CCOC2.O=C1OC(=O)C2=C1CCC2>>O=C(O)C1=C(C(=O)Nc2sc3c(c2-c2nc(C4CC4)no2)CCOC3)CCC1,,CC#N,CCOC(C)=O,C1CCC2=NCCCN2CC1,Cl,val
US20060270679A1,CCc1nnc2c(Cl)nccn12>>CCc1nnc2n1CCNC2.Cl,O=[Pt],CO,,,,val
US05412117,CCC1(C)C=C(C(=S)NC)c2cc(C#N)ccc2O1.Cc1ccc(S(=O)(=O)Cl)cc1>>CCC1(C)C=C(C(=O)NC)c2cc(C#N)ccc2O1,,c1ccncc1,,Cl,,val
US20050014787A1,CCOC(=O)CN(CCc1ccc(C(C)C)cc1)S(=O)(=O)c1cc(C#N)ccc1OC>>COc1ccc(C#N)cc1S(=O)(=O)N(CCc1ccc(C(C)C)cc1)CC(=O)O,,C1CCOC1,,Cl,[Na+].[OH-],val
US06399614B1,O=C(O)c1ncccn1.O=S(Cl)Cl>>O=C(Cl)c1ncccn1,,ClC(Cl)Cl,,Cl,,val
US20140249129A1,COC(=O)C(C)Br.N#Cc1ccc(C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)CCC3)cc1>>COC(=O)C(C)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20030114668A1,C=O.O=C1CNC(=O)C(Cc2cccc(NCc3ccccc3)c2)N1>>CN(Cc1ccccc1)c1cccc(CC2NC(=O)CNC2=O)c1,,CN(C)C=O,ClCCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20010039348A1,Nc1cc(Cl)cc(Cl)c1.Nc1ccc(NC(=O)c2csnn2)cc1.S=C(n1cncn1)n1cncn1>>O=C(Nc1ccc(NC(=S)Nc2cc(Cl)cc(Cl)c2)cc1)c1csnn1,,C1CCOC1,,,,val
US20100113410A1,Cc1cnc(C)c(Cl)c1.O=C(OO)c1cccc(Cl)c1>>Cc1cc(Cl)c(C)[n+]([O-])c1,,ClCCl,,,,val
US20100216765A1,Cc1cc(N)n[nH]1.Clc1cc(Cl)n2ccnc2n1>>Cc1cc(Nc2cc(Cl)nc3nccn23)n[nH]1,,CCO,,,,val
US05081311,CC(=O)CCC=CCCCCC=CCCC(C)=O>>CC(=O)CCCCCCCCCCCCC(C)=O,[Pd],CCOC(C)=O,,,,val
US20130172364A1,C#CCN.FC(F)(F)Oc1ccc2nc(CBr)sc2c1>>C#CCNCc1nc2ccc(OC(F)(F)F)cc2s1,,CC#N,,,,val
US20050239769A1,BrCCCCBr.CCCc1c(O)ccc2c(C(F)(F)F)noc12>>CCCc1c(OCCCCBr)ccc2c(C(F)(F)F)noc12,,CCOC(C)=O,CCOCC,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20100113465A1,C1CCOC1.C1COCCO1.CN(C)C=O.ClCCl>>O=C(Cl)Oc1ccccc1,,CN(C)C=O,CS(C)=O,CC#N,,val
US20080214612A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)S(=O)(=O)c1ccc(Br)cc1>>CN(C)S(=O)(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1,,CS(C)=O,,CC(=O)[O-].[K+],,val
US20050191238A1,CC(=O)COc1ccc(CO)cc1>>CC(O)COc1ccc(CO)cc1,,CO,O,[BH4-].[Na+],,val
US20080181866A1,N#Cc1cccc([C@H]2SCC(C(=O)O)N2C(=O)OCc2ccccc2)c1.Nc1nc(-c2ccc(C(=O)NC3CC3)cc2)cs1>>N#Cc1cccc([C@H]2SCC(C(=O)Nc3nc(-c4ccc(C(=O)NC5CC5)cc4)cs3)N2C(=O)OCc2ccccc2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140135332A1,CCOC(=O)CC(=O)OCC.CS(=O)(=O)OCCc1nc(-c2ccc(C(F)(F)F)cc2)c(Br)o1>>CCOC(=O)C(CCc1nc(-c2ccc(C(F)(F)F)cc2)c(Br)o1)C(=O)OCC,,C1CCOC1,,O,[H-].[Na+],val
US20140080808A1,CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(C3(c4ccc(-c5cccnc5C#N)cc4)CC3)n2CCS1>>CC1(CO)Cc2nnc(C3(c4ccc(-c5cccnc5C#N)cc4)CC3)n2CCS1,,CO,,Cl,,val
US20160075692A1,Fc1ccc(F)c([C@H]2C[C@H](F)CN2)c1.O=C(O)CN1CCN(c2cccc3c2cnn3-c2ccccc2F)C1=O>>O=C1N(CC(=O)N2C[C@@H](F)C[C@@H]2c2cc(F)ccc2F)CCN1c1cccc2c1cnn2-c1ccccc1F,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030045558A1,CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccc(-c4cccc5ccccc45)cc3)oc2C)cc1>>Cc1oc(-c2ccc(-c3cccc4ccccc34)cc2)nc1CCOc1ccc(OC(C)(C)C(=O)O)cc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20160097783A1,CC(C)(C)OC(=O)CBr.CCCC(C(=O)c1ccc(O)cc1)N1CCCC1>>CCCC(C(=O)c1ccc(OCC(=O)OC(C)(C)C)cc1)N1CCCC1,,C1CCOC1,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20040097555A1,CC(C)(C)c1ccc(-c2nc(N)sc2-c2ccncc2)cc1.O=C(Cl)c1cccnc1>>CC(C)(C)c1ccc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)cc1,CN(C)c1ccncc1,CC(=O)N(C)C,,Cl,O=C([O-])O.[Na+],val
US05574033,CC1SC(c2ccncc2)=NNC1=O.O=C(CBr)c1ccccc1Cl>>CC1SC(c2cc[n+](CC(=O)c3ccccc3Cl)cc2)=NNC1=O.[Br-],,CCO,,,,val
US20040192686A1,CC[Sn](CC)(CC)CC.[O-][n+]1nc(Cl)nc2ccccc21>>CCc1nc2ccccc2[n+]([O-])n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,,,val
US20090012289A1,O=C([O-])[C@H](O)c1ccccc1>>O=C(O)[C@@H](O)c1ccccc1,,O,,Cl,,val
US20090227570A1,COCCOc1cccc2c1C(=O)CO2.NO>>COCCOc1cccc2c1C(=NO)CO2,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20050192213A1,CCCCCI.Oc1ccc(-c2ccc(Br)cc2)cc1>>CCCCCOc1ccc(-c2ccc(Br)cc2)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US03941802,COC(OC)OC.NCC=O.Nc1ccccc1Cc1ccccc1Cl>>Clc1ccccc1Cc1ccccc1-n1ccnc1,Cl[Ti](Cl)(Cl)Cl,COCCOC,,,,val
US20060276508A1,COC(=O)C(C)(C)c1ccccc1.COC(Cl)Cl>>COC(=O)C(C)(C)c1ccc(C=O)cc1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,Cl,,val
US20050288270A1,CC(C)(C)OC(=O)N1CC(c2ccc(Cl)nc2)C1.ClCCl>>Cl.Cl.Clc1ccc(C2CNC2)cn1,,ClCCl,,,,val
US05147645,CCOC(=O)c1cccc(C)c1OCC>>CCOc1c(C)cccc1CO,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20080045536A1,COc1ccc(CNc2cc(N[C@@H]3CC[C@@H](N)CC3)nn3ccnc23)cc1>>Nc1cc(N[C@@H]2CC[C@@H](N)CC2)nn2ccnc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120041009A1,Clc1cc(Cl)ncn1.OB(O)c1ccccc1C(F)(F)F>>FC(F)(F)c1ccccc1-c1cc(Cl)ncn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US05360808,COC(=O)c1ccc(=O)n(CCN)c1.O=C(O)c1ccc(Cl)nc1>>COC(=O)c1ccc(=O)n(CCNC(=O)c2ccc(Cl)nc2)c1,,CCOC(C)=O,,CCN(CC)CC,ClCCl,val
US20100113502A1,CC(C)(C)OC(=O)N1CCc2[nH]c3ccc(C(=O)N4CCc5ccccc5C4)cc3c2C1.CCS(=O)(=O)Cl>>CCS(=O)(=O)n1c2c(c3cc(C(=O)N4CCc5ccccc5C4)ccc31)CN(C(=O)OC(C)(C)C)CC2,,CN(C)C=O,,[H-].[Na+],,val
US04792628,Cc1cc(CNC(=O)CCl)c(O)c2c1CCC2=O>>Cc1cc(CN)c(O)c2c1CCC2=O,,CCO,,O=S(=O)(O)O,,val
US05376725,C=C1C=CC(c2ccccc2)=C1c1ccccc1.[Li]CCCC.c1ccc2c(c1)Cc1ccccc1-2>>C1=C(C(c2ccccc2)(c2ccccc2)C2c3ccccc3-c3ccccc32)CCC1,,C1CCOC1,O,CCCCCC,,val
US20150133457A1,COCCOc1c(F)cc(Nc2nc(Oc3cccc([N+](=O)[O-])c3)c3cc[nH]c3n2)cc1F>>COCCOc1c(F)cc(Nc2nc(Oc3cccc(N)c3)c3cc[nH]c3n2)cc1F,O=[Pt]=O,C1CCOC1,,[H][H],,val
US20160237076A1,COc1ccc(-c2nc(CO)c(C)s2)cc1OCCF.O=C(C(Br)(Br)Br)C(Br)(Br)Br>>COc1ccc(-c2nc(CBr)c(C)s2)cc1OCCF,,CC#N,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130241401A1,Brc1ccc2c(c1)c1ccccc1n2-c1ccc2c3ccccc3c3ccccc3c2c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC1(C)OB(c2ccc3c(c2)c2ccccc2n3-c2ccc3c4ccccc4c4ccccc4c3c2)OC1(C)C,,C1COCCO1,,ClCCl,CC(=O)[O-].[K+],val
US20040116330A1,Fc1cccc(F)c1/C=C/c1nc(CCl)co1.Oc1ccc(CCCCn2ccnn2)cc1>>Fc1cccc(F)c1/C=C/c1nc(COc2ccc(CCCCn3ccnn3)cc2)co1,,CN(C)C=O,,O,[H-].[Na+],val
US05028606,CC(C)C(c1ccc(N)c([N+](=O)[O-])c1)n1cncn1.O=C(Cl)Cc1ccc(Cl)cc1>>CC(C)C(c1ccc(NC(=O)Cc2ccc(Cl)cc2)c([N+](=O)[O-])c1)n1cncn1,,ClCCl,,c1ccncc1,,val
US20150133510A1,CC(C)(C)c1ccc(CN(Cc2ccccc2)Cc2ccc(C(C)(C)C)cc2)cc1.CS(=O)(=O)O>>CC(C)(C)c1ccc(C[NH+](Cc2ccccc2)Cc2ccc(C(C)(C)C)cc2)cc1.CS(=O)(=O)[O-],,CCOCC,,,,val
US20100317643A1,Nc1ccncc1F.O=C(Cl)c1c(Cl)cccc1Cl>>O=C(Nc1ccncc1F)c1c(Cl)cccc1Cl,,CC#N,ClCCl,CCN(C(C)C)C(C)C,,val
US20150011562A1,Cc1ccccc1N1CCN(c2cc(C3CC3)c(C(=O)NCCCN3CCCC3=O)cc2N)CC1.O=C(Cl)c1ccco1>>Cc1ccccc1N1CCN(c2cc(C3CC3)c(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccco2)CC1,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US20040024010A1,O=C1Cc2ccc(-c3ccccc3)cc2N1.O=Cc1[nH]c2c(c1CCC(=O)O)CCCC2>>O=C(O)CCc1c(C=C2C(=O)Nc3cc(-c4ccccc4)ccc32)[nH]c2c1CCCC2,C1CCNCC1,CCO,,,,val
US20090197863A1,COC(=O)c1cccc2nc(-c3ccc(-c4ccncc4)cc3F)oc12.N>>NC(=O)c1cccc2nc(-c3ccc(-c4ccncc4)cc3F)oc12,,CO,,,,val
US20030050298A1,CN(C)S(=O)(=O)c1c(Cl)ccc([N+](=O)[O-])c1Cl.O>>CN(C)S(=O)(=O)c1c(Cl)ccc([N+](=O)[O-])c1O,,CCOC(C)=O,,[H-].[Na+],,val
US20160009683A1,CCOC(=O)C(F)(F)Br.C[Si](C)(C)c1c(F)ccc(I)c1OC(F)(F)F>>CCOC(=O)C(F)(F)c1ccc(F)cc1OC(F)(F)F,[Cu],CS(C)=O,,,,val
US20120264738A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CO)OC1.Cl>>Cl.N[C@@H]1CC[C@@H](CO)OC1,,CO,,C1COCCO1,,val
US20080234335A1,CCOC(=O)c1cc(Cl)cc(C2=C(O)CCCC2)n1>>CCOC(=O)c1cccc(C2=C(O)CCCC2)n1,[Pd],C1CCOC1,CCO,,,val
US20070275987A1,CCCCc1cnc(Cl)c(C(=O)NC(=N)COCCc2cc(F)ccc2F)c1>>CCCCc1cnc2nc(COCCc3cc(F)ccc3F)[nH]c(=O)c2c1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US05574039,O=C1Nc2cccc3cccc1c23.O=[N+]([O-])O>>O=C1Nc2ccc([N+](=O)[O-])c3cccc1c23,,CC(=O)O,,,,val
US20100004269A1,COC(=O)c1cc(F)c(CNC=O)nc1Nc1ccc(Br)cc1F>>COC(=O)c1cc(F)c2cncn2c1Nc1ccc(Br)cc1F,,Cc1ccccc1,,O=P(Cl)(Cl)Cl,,val
US20080234255A1,C=C(C)C(=O)OC.CC(C)CCN>>COC(=O)C(C)CNCCC(C)C,,CO,,,,val
US20140018313A1,CC(C)(C)OC(=O)N1[C@@H](CO)CC[C@H]1C(=O)O.COS(=O)(=O)OC>>COC[C@H]1CC[C@@H](C(=O)O)N1C(=O)OC(C)(C)C,,C1CCOC1,,[Li]CCCC,,val
US20080167361A1,COc1cc(S(=O)c2ccccc2C#N)ccc1C1CCN(C(=O)OC(C)(C)C)C1.O=C(OO)c1cccc(Cl)c1>>COc1cc(S(=O)(=O)c2ccccc2C#N)ccc1C1CCN(C(=O)OC(C)(C)C)C1,,ClCCl,,,,val
US20140329798A1,CNC.O=C(O)Cc1cc(F)c(OCC[C@@H]2C[C@@H]2C2CCN(C(=O)OCc3ccccc3)CC2)cc1F>>CN(C)C(=O)Cc1cc(F)c(OCC[C@@H]2C[C@@H]2C2CCN(C(=O)OCc3ccccc3)CC2)cc1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040077853A1,CCc1cc(-c2cccc(NC(=O)C(C)(C)C)n2)c(OC)cc1CCO[Si](C)(C)C(C)(C)C>>CCc1cc(-c2cccc(NC(=O)C(C)(C)C)n2)c(OC)cc1CCO,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100273775A1,CC(N)CO.O=C(OCc1ccccc1)N1CCCc2c(-c3ccnc(Cl)n3)c(-c3ccc(F)cc3)nn21>>CC(CO)Nc1nccc(-c2c(-c3ccc(F)cc3)nn3c2CCCN3C(=O)OCc2ccccc2)n1,,ClC(Cl)Cl,,,,val
US05591762,CCCc1nc2cc(-c3cn4ccccc4n3)ccc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCc1nc2cc(-c3cn4ccccc4n3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100204240A1,CC1(C)OC[C@](C)(C=O)O1.NO>>CC1(C)OC[C@](C)(C=NO)O1,,CO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20160207893A1,COC(=O)c1ccc(C=O)cc1F.COc1cnc2c(c1)CNCCS2>>COC(=O)c1ccc(CN2CCSc3ncc(OC)cc3C2)cc1F,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04806538,CCOC(=O)[C@@H](CCSC)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)OC(C)(C)C>>CSCC[C@H]1NC(=O)[C@@H](Cc2cn(C)c3ccccc23)NC1=O,,O=CO,,Cl,,val
US07015218B1,CC(C)Cc1ccc(N)cc1C#N.Cc1nn(-c2ccc(F)cc2)cc1C(=O)O>>Cc1nn(-c2ccc(F)cc2)cc1C(=O)Nc1ccc(CC(C)C)c(C#N)c1,,CN(C)C=O,O,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US04711958,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H](CC1CCCCC1)C(O)C(=O)O>>CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)C(O)C(=O)O,,C1COCCO1,O,CCN(CC)CC,Cl,val
US20150335651A1,COS(=O)(=O)OC.O=C(O)c1c(F)cccc1I>>COC(=O)c1c(F)cccc1I,,C1CCOC1,,O,[Li]O,val
US20110046133A1,COC(=O)CBr.Cc1cc(O)cc(C)c1C=O>>COC(=O)COc1cc(C)c(C=O)c(C)c1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20110196002A1,CCOC(=O)c1cc(-c2ccc(NC(=O)Nc3ccccc3F)cc2)no1>>O=C(Nc1ccc(-c2cc(C(=O)O)on2)cc1)Nc1ccccc1F,,C1CCOC1,,Cl,[Na+].[OH-],val
US04230713,CN1CC(=O)N=C1N.Cc1ccc(N=C=O)s1>>Cc1ccc(NC(=O)N=C2NC(=O)CN2C)s1,,CN(C)C=O,Cc1ccccc1,O,,val
US20120010241A1,Cc1nn(-c2ccc(C#N)c(NC3CC(C)(C)NC(C)(C)C3)c2)c2cccc(-c3cnc4ccccc4c3)c12.OO>>Cc1nn(-c2ccc(C(N)=O)c(NC3CC(C)(C)NC(C)(C)C3)c2)c2cccc(-c3cnc4ccccc4c3)c12,,CS(C)=O,O,CCO,[Na+].[OH-],val
US20150031708A1,CC1(C)OB(c2ccc(=O)n(CCS(C)(=O)=O)c2)OC1(C)C.Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1Cl>>Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1-c1ccc(=O)n(CCS(C)(=O)=O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,ClCCl,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US04595700,CCCCC(C)C(C(=O)[O-])=C(C)CC>>CC=C(C(=O)O)C(C)CCCC,,CO,O,[Na+].[OH-],,val
US03970683,C=[N+]=[N-].O=C(O)CCCCCCC1=CC(O)CC1=O>>COC(=O)CCCCCCC1=CC(O)CC1=O,,CO,,,,val
US20100305093A1,CC(C)(C)OC(=O)N1CCOc2ccc(-c3ccc(NCCN4CCCC4)[n+]([O-])c3)cc2C1.CCc1c(C(=O)O)ccc(S(C)(=O)=O)c1F>>CCc1c(C(=O)N2CCOc3ccc(-c4ccc(NCCN5CCCC5)nc4)cc3C2)ccc(S(C)(=O)=O)c1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06057332,CCOC(=O)CC(=O)CCl.OCCCc1ccccc1>>O=C(CCl)CC(=O)OCCCc1ccccc1,,Cc1ccccc1,,CCO,,val
US20040157909A1,Cc1[nH]c(C=O)c(C)c1C(=O)NCCN(C(C)C)C(C)C.O=C1Cc2c(cccc2-c2cccc(Br)c2)N1>>Cc1[nH]c(C=C2C(=O)Nc3cccc(-c4cccc(Br)c4)c32)c(C)c1C(=O)NCCN(C(C)C)C(C)C,C1CCNCC1,CCO,,,,val
US20110098290A1,COC(=O)c1cc(C(C)C)c(OC)cc1OC>>COc1cc(OC)c(C(C)C)cc1C(=O)O,,CO,O,[K+].[OH-],,val
US20130217680A1,O=C(Cc1ccc(-n2cnnn2)cc1)N1CC2CC1CN2C(=O)OCc1ccccc1>>O=C(Cc1ccc(-n2cnnn2)cc1)N1CC2CC1CN2,[Pd],CO,,,,val
US20050026940A1,C=CCNC(=O)COC.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=CCN(C(=O)COC)C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,O,val
US06087380,CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C#N)cc1)n2C)c1ccccc1.NO>>CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)NO)cc1)n2C)c1ccccc1,,CCO,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US06001836,COc1cccc(C2CCNCC2)c1.N#CCBr>>COc1cccc(C2CCN(CC#N)CC2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040110826A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc(CNc2ncc(C=O)c3nc(-c4ccco4)nn23)cc1OC>>COc1ccc(CN(C(=O)OC(C)(C)C)c2ncc(C=O)c3nc(-c4ccco4)nn23)cc1OC,,CCOC(C)=O,ClCCl,CCN(CC)CC,CN(C)c1ccccn1,val
US20010025109A1,CC(=O)Cl.N[C@@H](CCO)C(=O)O>>CC(=O)OCC[C@H](N)C(=O)O.Cl,,CC(=O)O,,,,val
US20160176825A1,COc1ccc([N+](=O)[O-])cc1Nc1ncc2c(n1)N(C)C(=O)N(c1ccccc1)C2>>COc1ccc(N)cc1Nc1ncc2c(n1)N(C)C(=O)N(c1ccccc1)C2,,CO,,,,val
US20030045507A1,Fc1c(F)c(F)c(B(c2c(F)c(F)c(F)c(F)c2F)c2c(F)c(F)c(F)c(F)c2F)c(F)c1F>>Fc1cc(F)c(F)c(F)c1F,,O,,,,val
US20040138277A1,CCOC(=O)C(C)(Oc1ccc(F)cc1)C(OC(=O)C(F)(F)F)c1ccc(OCc2ccccc2)cc1>>CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccc(F)cc1,[Pd],CCOC(C)=O,,,,val
US20160090374A1,NC(N)=O.Nc1ccccc1C(=O)O>>Oc1nc(O)c2ccccc2n1,,O,,,,val
US06395731B1,CC(C)(C)OC(=O)NCc1ncccc1-c1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc4cc(Cl)ccc4c3)CC2)cc1>>NCc1ncccc1-c1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc4cc(Cl)ccc4c3)CC2)cc1,,C1CCOC1,,Cl,,val
US20130072467A1,CC(C)(C)OC(=O)CN.O=C1NC(=S)CS1>>CC(C)(C)OC(=O)CNC1=NC(=O)SC1,,CCO,,CCN(CC)CC,Cl,val
US06218384B1,CC1C=CC=Cn2c1nc1c2CCCC1=O.O=C=Nc1ccccc1F>>CC1C=CC=CN2C3=C(C(=O)CCC3)N(C(=O)Nc3ccccc3F)C12,,ClCCl,,,,val
US20130116263A1,CSc1ncc(CO)c(NCc2cccnc2)n1>>CSc1ncc(C=O)c(NCc2cccnc2)n1,O=[Mn]=O,ClCCl,,,,val
US04360466,CC(=O)Nc1ccc(C=O)cc1.COC(OC)N(C)C.Nc1cc(Cl)c(N)c(Cl)c1>>CC(=O)Nc1ccc(C=Nc2cc(Cl)c(N=CN(C)C)c(Cl)c2)cc1,,CCCCCC,CCO,,,val
US20100216788A1,CC(C)(C)OC(=O)N1CCC(Cn2ccc3cc([N+](=O)[O-])ccc32)CC1>>CC(C)(C)OC(=O)N1CCC(Cn2ccc3cc(N)ccc32)CC1,[Pt],CCOC(C)=O,,,,val
US20110021771A1,COC(=O)c1sc(CO)cc1-c1ccccc1.O=[Cr](=O)=O>>COC(=O)c1sc(C(=O)O)cc1-c1ccccc1,,CC(C)=O,,O=S(=O)(O)O,,val
US20160046616A1,Nc1cccc(B(O)O)c1.O=C(O)Cc1ccc2c(c1)OCO2>>O=C(Cc1ccc2c(c1)OCO2)Nc1cccc(B(O)O)c1,,ClCCl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090170882A1,FC(F)(F)c1ccc2c(c1)[nH]c1ccccc12.O=[N+]([O-])O>>O=[N+]([O-])c1ccc2[nH]c3cc(C(F)(F)F)ccc3c2c1,,CC(=O)O,,,,val
US04602027,Cc1oc(C2(C)CCCCC2)nc1CC(=O)OCc1ccccc1>>Cc1oc(C2(C)CCCCC2)nc1CC(=O)O,,CCO,O,[Na+].[OH-],,val
US03963776,CI.NN1CCOCC1>>C[N+]1(N)CCOCC1.[I-],,CCOCC,,,,val
US04524207,CN1CCC2(CC1)SC(c1cccc(F)c1)c1ccccc12.O=C(Cl)Oc1ccccc1>>O=C(Oc1ccccc1)N1CCC2(CC1)SC(c1cccc(F)c1)c1ccccc12,,ClCCl,,,,val
US20090042891A1,Nc1cnc(Br)c(-c2cccc(F)c2)n1.OB(O)c1ccncc1Cl>>Nc1cnc(-c2ccncc2Cl)c(-c2cccc(F)c2)n1,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05521192,CC(=O)CCCC#N.FC(F)(F)c1ccc(-c2cccc(Br)c2)cc1>>CC(O)(CCCC#N)c1cccc(-c2ccc(C(F)(F)F)cc2)c1,,C1CCOC1,CCOCC,[Li]CCCC,,val
US20010047038A1,COC(=O)c1cc([N+](=O)[O-])c(N)cc1OC>>COC(=O)c1cc(N)c(N)cc1OC,[Ni],C1CCOC1,,,,val
US20120196833A1,CP(C)(=O)CCN.O=Cc1ccc(-c2ccc3ncnc(Nc4ccc5c(cnn5Cc5cccc(F)c5)c4)c3c2)o1>>CP(C)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc5c(cnn5Cc5cccc(F)c5)c4)c3c2)o1,CC(=O)O,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20050182058A1,CC(C)(OC1CCC(C(O)c2ccn3ncnc(Nc4ccc(F)c(Cl)c4)c23)CC1)[Si](C)(C)C>>O[C@@H]1CC[C@@H](Cc2ccn3ncnc(Nc4ccc(F)c(Cl)c4)c23)CC1,,O=C(O)C(F)(F)F,,,,val
US20140128368A1,CCCC[Sn](CCCC)(CCCC)c1ncco1.CCc1cnc(N2CCC([C@H]3C[C@H]3COCc3ccc(Br)cc3)CC2)nc1>>CCc1cnc(N2CCC([C@H]3C[C@H]3COCc3ccc(-c4ncco4)cc3)CC2)nc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,,,,val
US06162824,BrCCCOC1CCCCO1.c1ccc(C2c3ccccc3-c3ccccc32)cc1>>OCCCC1(c2ccccc2)c2ccccc2-c2ccccc21,[Zn],C1CCOC1,CC(=O)O,[Li]CCCC,,val
US20040087588A1,CC(C)(C)OC(=O)Nc1cccc(C#N)c1.NO>>CC(C)(C)OC(=O)Nc1cccc(C(=N)NO)c1,,CO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US06759547B1,CCOC(=O)/C(F)=C(C)/C=C/C(F)=C(/CC)c1cc2c(cc1OCOC)C(C)(C)CCC2(C)C>>CCOC(=O)/C(F)=C(C)/C=C/C(F)=C(/CC)c1cc2c(cc1O)C(C)(C)CCC2(C)C,,C1CCOC1,CC(C)O,Cl,,val
US05296344,CC(=O)CCC(C)=O.CCOC(=O)c1ccc(N)cc1>>CCOC(=O)c1ccc(-n2c(C)ccc2C)cc1,O=S(=O)(O)O,CCOC(C)=O,,,,val
US06498251B1,CC(=O)OCCBr.CC(C)(C)OC(=O)N1CCc2c([nH]c3ccccc23)C1>>CC(=O)OCCn1c2c(c3ccccc31)CCN(C(=O)OC(C)(C)C)C2,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20150148341A1,COC(=O)[C@]12Cc3cnn(-c4ccc(F)cc4)c3C[C@@H]1CCN(C(=O)OC(C)(C)C)C2.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1>>COC(=O)[C@]12Cc3cnn(-c4ccc(F)cc4)c3C[C@@H]1CCN(S(=O)(=O)c1ccc(C(F)(F)F)cc1)C2,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20150031674A1,CC(C)(C)OC(=O)N1CCC(O)C1.CCOC(=O)CCl>>CCOC(=O)COC1CCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,[H-].[Na+],,val
US20120270824A1,CC(=O)OC[C@H]1O[C@H](O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.N#CC(Cl)(Cl)Cl>>CC(=O)OC[C@H]1O[C@H](OC(=N)C(Cl)(Cl)Cl)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,ClCCl,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060223152A1,CCCCCCCC(=O)OC(=O)CCCCCCC.C[C@@H](N)c1ccccc1>>CCCCCCCC(=O)N[C@H](C)c1ccccc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20100261687A1,COC(=O)c1cc(NC(=O)OC(C)(C)C)cc(C(C)(C)C)c1>>CCOC(=O)c1cc(N)cc(C(C)(C)C)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05688815,O=c1ccn(CCO)c(C(O)c2cccnc2)c1OCc1ccccc1>>O=c1ccn(CCO)c(C(O)c2cccnc2)c1O,,CO,,,,val
US20110009421A1,Cc1ccc(O)c(C)c1.Clc1cccc(Cl)n1>>Cc1ccc(Oc2cccc(Cl)n2)c(C)c1,,O,,O=C([O-])[O-].[K+].[K+],,val
US05110812,CC(=O)Cl.CCS[C@@H]1NC(=O)[C@H]1CCCNC(=NC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1>>CCS[C@H]1[C@H](CCCNC(=NC(=O)OCc2ccccc2)NC(=O)OCc2ccccc2)C(=O)N1C(C)=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20080146566A1,CO.Cc1ccc(C(=O)O)cc1-n1ccc2ccc(O)cc2c1=O>>COC(=O)c1ccc(C)c(-n2ccc3ccc(O)cc3c2=O)c1,,ClCCl,,CN(C)C=O,O=S(Cl)Cl,val
US06204277B1,CCOC(C)=O.Cc1oc(-c2ccccc2)nc1CCOc1ccc(CC(O)C(N)=O)cc1>>COC(=O)OC(Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)cc1)C(N)=O,,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20120058984A1,Nc1ccc(CCC(=O)O)cc1.O=S(=O)(Cc1ccccc1)c1nc(CN2CCCCC2)cc(Nc2nc3cccnc3s2)n1>>O=C(O)CCc1ccc(Nc2nc(CN3CCCCC3)cc(Nc3nc4cccnc4s3)n2)cc1,Cl,CC#N,,,,val
US05665270,CCCCC(=O)O.CCCCCc1ccc(-c2ccc(-c3ncc(OCC(O)C(F)(F)F)cn3)cc2)cc1>>CCCCCc1ccc(-c2ccc(-c3ncc(OCC(OC(=O)CCCC)C(F)(F)F)cn3)cc2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100144722A1,COC(=O)C1(c2ccc(N)cc2)CCC1.Fc1ccc(-c2cc(N3CCOCC3)nc(Cl)n2)cc1>>COC(=O)C1(c2ccc(Nc3nc(-c4ccc(F)cc4)cc(N4CCOCC4)n3)cc2)CCC1,,CCCCO,,,,val
US05753664,Cn1ncc2[nH]ccc2c1=O.O=C(c1ccc(Cl)cc1)c1ccc(CBr)cc1>>Cn1ncc2c(ccn2Cc2ccc(C(=O)c3ccc(Cl)cc3)cc2)c1=O,,CN(C)C=O,,O,[H-].[Na+],val
US05691374,CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1.O=C(OOC(=O)c1ccccc1)c1ccccc1>>CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2OC(=O)c2ccccc2)cc1,,CCOC(C)=O,ClCCl,C1CCC2=NCCCN2CC1,,val
US20080188528A1,CCOC=N.NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)s1)C(=O)O.O=C(O)C(F)(F)F>>N=CNCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)s1)C(=O)O.O=C(O)C(F)(F)F,,CCN(CC)CC,,CCO,Cl,val
US20130029969A1,Cc1[nH]ncc1-c1cc2nc([C@@H]3[C@H]4CC[C@H](C4)N3C(=O)OC(C)(C)C)[nH]c(=O)c2s1>>Cc1[nH]ncc1-c1cc2nc([C@H]3N[C@@H]4CC[C@H]3C4)[nH]c(=O)c2s1,,CO,,CCOC(C)=O,Cl,val
US20140364395A1,CCI.O=Cc1ccnc2[nH]ccc12>>CCn1ccc2c(C=O)ccnc21,,CN(C)C=O,O,[H-].[Na+],[Cl-].[NH4+],val
US20070208150A1,CCCCI.CCOC(=O)C(C(C)=O)C1CCCC1>>CCCCC(C(C)=O)(C(=O)OCC)C1CCCC1,,CN(C)C=O,,[H][H],[H-].[Na+],val
US05179212,CS(=O)(=O)OC[C@@H](O)CC#N.Cl>>CS(=O)(=O)OC[C@@H](O)CCN.Cl,[Pd],CO,,[H][H],,val
US20090209607A1,C/C=C\B(O)O.COC(=O)c1cc(-c2c(Br)cnn2C)c(C)s1>>C/C=C\c1cnn(C)c1-c1cc(C(=O)OC)sc1C,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20150045359A1,CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(C(=O)N[C@@H](CO)c3ccc(F)cc3)cc2)C1>>O=C(N[C@@H](CO)c1ccc(F)cc1)c1ccc([C@H]2CNCCO2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04136189,Nc1cccc2c1=NC(=Cc1ccc([N+](=O)[O-])o1)N=2.O=C=Nc1cccc(Cl)c1>>Nc1cccc2c1NC(=Cc1ccc([N+](=O)[O-])o1)N2C(=O)Nc1cccc(Cl)c1,,CN(C)C=O,ClC(Cl)Cl,,,val
US20050222140A1,C#CC(=O)OCC.Nc1cc[nH]n1>>Oc1ccn2nccc2n1,,C1COCCO1,,Cc1ccccc1,,val
US06420410B1,COc1ccc([N-]Cc2cc(OC)c(OC)c(OC)c2)c([N+](=O)[O-])c1>>COc1ccc(NCc2cc(OC)c(OC)c(OC)c2)c(N)c1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140228394A1,CC(C)(C)OC(=O)N1CCc2cc(Br)sc2C1.Cc1ccncc1N1CCNC1=O>>Cc1ccncc1N1CCN(c2cc3c(s2)CN(C(=O)OC(C)(C)C)CC3)C1=O,I[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US07524840B2,ClCCCN1CCOCC1.O=C1CN=C(c2ccccc2Cl)c2cc(Br)c(O)cc2N1>>O=C1CN=C(c2ccccc2Cl)c2cc(Br)c(OCCCN3CCOCC3)cc2N1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20050065210A1,CCCCN=C=O.CN(CC[C@@H]1CC[C@@H](C(=O)N2CCCN(CCO)CC2)CC1)c1ncc(Br)cn1>>CCCCNC(=O)OCCN1CCCN(C(=O)[C@@H]2CC[C@@H](CCN(C)c3ncc(Br)cn3)CC2)CC1,,ClCCl,,,,val
US20070149574A1,Cc1cc(C)cc(N(CC(=O)OC(C)(C)C)C(=O)c2cccnc2SCc2ccnc(N)c2)c1.Cl>>Cc1cc(C)cc(N(CC(=O)O)C(=O)c2cccnc2SCc2ccnc(N)c2)c1.Cl,,CCOC(C)=O,,,,val
US20050171180A1,CCC(C=O)CC.Cc1ccc(S(=O)(=O)n2cccn2)cc1>>CCC(CC)C(O)c1ccnn1S(=O)(=O)c1ccc(C)cc1,,C1CCOC1,,[Li]C(C)(C)C,,val
US20070219234A1,CC(C)CN.CCO/C(C)=C(/C#N)C(N)=S>>C/C(NCC(C)C)=C(\C#N)C(N)=S,,CCO,,,,val
US20080125413A1,CC(C)(C)OC(=O)N(CC=O)C1CCN(C(=O)OCc2ccccc2)CC1.CC(C)(C)S(N)=O>>CC(C)(C)OC(=O)N(C/C=N/S(=O)C(C)(C)C)C1CCN(C(=O)OCc2ccccc2)CC1,,CC(Cl)Cl,,,,val
US20160237075A1,NC(=O)c1cn(-c2ccc([N+](=O)[O-])cc2)nc1-c1ccc(Oc2ccccc2)cc1>>NC(=O)c1cn(-c2ccc(N)cc2)nc1-c1ccc(Oc2ccccc2)cc1,[Zn],CCO,,[Cl-].[NH4+],,val
US20090192138A1,COC(=O)c1c(Cl)n(COCC[Si](C)(C)C)c2c(=O)n(COCC[Si](C)(C)C)cnc12>>COC(=O)c1c(Cl)[nH]c2c(=O)[nH]cnc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040229900A1,CC(C)N=C=O.c1ccc(CN2CC3CNCC(C3)C2)cc1>>CC(C)NC(=O)N1CC2CC(CN(Cc3ccccc3)C2)C1,,ClCCl,,,,val
US04780471,C=C(CBr)c1ccccc1OCc1ccc(Cl)cc1Cl.c1nc[nH]n1>>C=C(Cn1cncn1)c1ccccc1OCc1ccc(Cl)cc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06057345,CCI.CCOC(=O)c1ccc(CNCc2cc(Br)ccc2OCc2ccccc2)cc1>>CCOC(=O)c1ccc(CN(CC)Cc2cc(Br)ccc2OCc2ccccc2)cc1,,CN(C)C=O,O,CC(=O)O,[H-].[Na+],val
US04772600,CN(C)CCN.O=C(O)Cn1c(-c2cccc(Cl)c2)nc2cccnc21>>CN(C)CCNC(=O)Cn1c(-c2cccc(Cl)c2)nc2cccnc21,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20100190806A1,COc1cccc(N)c1.Cc1nc(Cl)c2[nH]cnc2n1>>COc1cccc(Nc2nc(C)nc3nc[nH]c23)c1,,CCCCO,,CCN(CC)CC,,val
US20150148342A1,Cc1ccc(S(=O)(=O)n2ccc3c(-c4ccc5c(c4OCC4CCC4)n(CCC4CCNCC4)c(=O)n5C)cn(C)c(=O)c32)cc1>>Cn1cc(-c2ccc3c(c2OCC2CCC2)n(CCC2CCNCC2)c(=O)n3C)c2cc[nH]c2c1=O,,CO,O,[Na+].[OH-],,val
US20120295884A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(OCc1ccccc1)[C@@H]1[C@H](O)[C@@H](F)CN1C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N1C[C@H](F)[C@@H](O)[C@H]1C(=O)O,[Pd],CO,,[Na+].[OH-],,val
US04587256,CC(=O)OC(C)=O.Nc1cc(F)cc2c1OCCC21SC(=O)NC1=O>>CC(=O)Nc1cc(F)cc2c1OCCC21SC(=O)NC1=O,,CC(=O)OC(C)=O,,CC(=O)O,,val
US20100016319A1,C1COCCN1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2cc(C)nc(Cl)n2)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2cc(C)nc(N3CCOCC3)n2)cc1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20120315625A1,C#CCCCOCc1ccccc1.C1CCOC1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=S(=O)(Oc1cc(I)c(I)cc1OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=S(=O)(Oc1cc(C#CCCCOCc2ccccc2)c(C#CCCCOCc2ccccc2)cc1OS(=O)(=O)C(F)(F)F)C(F)(F)F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,CCN(CC)CC,,val
US20140051679A1,BrC1CCCC1.COC(=O)Cc1ccccc1OC>>COc1ccccc1C(C(=O)O)C1CCCC1,,CN(C)C=O,,[H-].[Na+],,val
US20160108037A1,COC(=O)c1ccc(C(F)(F)F)nc1NN.COCC(=O)Cl>>COCC(=O)NNc1nc(C(F)(F)F)ccc1C(=O)OC,,C1CCOC1,,CCN(CC)CC,,val
US20070213323A1,CC(=O)Cl.NCCOc1ccc(-c2ccc(=O)n(Cc3ccc(Cl)cc3F)c2)cc1>>CC(=O)NCCOc1ccc(-c2ccc(=O)n(Cc3ccc(Cl)cc3F)c2)cc1,,ClCCl,,CCN(CC)CC,,val
US20150299189A1,Cc1cc([N+](=O)[O-])cc2ccn(Cc3cccc(F)c3)c12>>Cc1cc(N)cc2ccn(Cc3cccc(F)c3)c12,[Fe],O,,CCO,[Cl-].[NH4+],val
US20150126490A1,CC(C)(C)OC(=O)c1ccc(-c2nc(C3=CC(=O)CCC3)cnc2N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1F>>CC(C)(C)OC(=O)c1ccc(-c2nc(C3CCCC(=O)C3)cnc2N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1F,[Pd],CO,ClCCl,,,val
US20150315149A1,CN1CCN(c2cc(Cl)c([N+](=O)[O-])cn2)CC1.Cc1ccccc1OBO>>Cc1ccccc1-c1cc(N2CCN(C)CC2)ncc1[N+](=O)[O-],c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,Cc1ccccc1,O,val
US20030162794A1,N.N#CC(c1ccnc(Cl)n1)c1nc2ccccc2s1>>N#CC(c1ccnc(N)n1)c1nc2ccccc2s1,,CCO,,,,val
US20150073011A1,CN(C)C(=O)C1=C[C@@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)OC(C)(C)C)C[C@@H]1O>>CN(C)C(=O)C1=C[C@@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)OC(C)(C)C)CC1=O,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20100004280A1,CCC(C)(C)CC(O)CNC(=O)C1(Cc2ccc(-c3ccc(F)cn3)cc2)CCC(=O)N1>>CCC(C)(C)CC(=O)CNC(=O)C1(Cc2ccc(-c3ccc(F)cn3)cc2)CCC(=O)N1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20150141433A1,Cc1ncc(CNC(=O)c2cnc(CN=[N+]=[N-])cn2)s1>>Cc1ncc(CNC(=O)c2cnc(CN)cn2)s1,[Pd],CO,,,,val
US20110312911A1,NC(=O)c1cc(Cl)cc(O[C@@H](c2ccc(Cl)cc2)[C@H](CCC(F)(F)F)c2ccc(C(=O)NCCC(=O)O)cc2)c1>>N#Cc1cc(Cl)cc(O[C@@H](c2ccc(Cl)cc2)[C@H](CCC(F)(F)F)c2ccc(C(=O)NCCC(=O)O)cc2)c1,Cl[Pd]Cl,CC#N,O,,,val
US04346231,C=C(C)C(=O)Cl.CC(=O)CC(=O)N1CCNCC1>>C=C(C)C(=O)N1CCN(C(=O)CC(C)=O)CC1,,CN(C)C=O,,Br,CCN(CC)CC,val
US04595683,COC(=N)NC(=O)OC.O=S(=O)(Cl)NCc1ccccc1>>COC(=O)NC(=NS(=O)(=O)NCc1ccccc1)OC,,C1CCOC1,,CCN(CC)CC,,val
US05624935,CC(C)(C)[Si](C)(C)Cl.CCOC(=O)C(N=[N+]=[N-])C(O)c1cccnc1Cl>>CCOC(=O)C(N=[N+]=[N-])C(O[Si](C)(C)C(C)(C)C)c1cccnc1Cl,,CN(C)C=O,,c1c[nH]cn1,,val
US20020016328A1,COC(=O)c1c(Cl)cc(C)nc1Oc1c(C)cc(C)cc1C.OCCNCc1cccs1>>COC(=O)c1c(N(CCO)Cc2cccs2)cc(C)nc1Oc1c(C)cc(C)cc1C,,CN1CCCC1=O,,,,val
US20080027112A1,COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1O[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O>>COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O,,CO,,CCN(CC)CC,O,val
US20020198197A1,COc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3ccnn3)c2)cc1C(F)(F)F>>COc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-n3ccnn3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040204427A1,COc1ccc(N2Cc3cnc(Nc4ccccc4)nc3N(C3CCCN(C(=O)OC(C)(C)C)C3)C2=O)cc1>>COc1ccc(N2Cc3cnc(Nc4ccccc4)nc3N(C3CCCNC3)C2=O)cc1,,ClCCl,O=C(O)C(F)(F)F,O,,val
US20120208817A1,CON(C)C(=O)c1ccncc1.Cl[Mg]Cc1ccccc1>>O=C(Cc1ccccc1)c1ccncc1,,C1CCOC1,,,,val
US20060074075A1,CC(C)(C)OC(=O)NCCc1c[nH]c2cc([N+](=O)[O-])ccc12>>CC(C)(C)OC(=O)NCCc1c[nH]c2cc(N)ccc12,[Ni],CCO,,,,val
US07241773B2,Cl.c1ccc(Oc2ccc(O[C@@H]3CN4CCC3CC4)cc2)cc1>>Cl.c1ccc(Oc2ccc(O[C@@H]3CN4CCC3CC4)cc2)cc1,,C1COCCO1,CCOC(C)=O,,,val
US20120277220A1,CCN1CCN(c2ccc(Nc3ncc4c(=O)c(C(N)=O)c(N)n(CC(C)(C)O)c4n3)c(OC)c2)CC1.Cl>>CCN1CCN(c2ccc(Nc3ncc4c(=O)c(C(N)=O)c(N)n(CC(C)(C)O)c4n3)c(OC)c2)CC1.Cl,,C1COCCO1,CO,CCOCC,,val
US20150080588A1,CC(C)(C)OC(=O)N[C@@H]1C=C[C@@](CO)(CCO)C1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N[C@H]1C[C@]2(CO)CCO[C@@H]2[C@H]1Br,,CCOC(C)=O,,O,,val
US05134128,CCCC[Sn](CCCC)(CCCC)COCCCc1ccc2ccccc2c1.C[Si](C)(C)c1cc(C=O)co1>>C[Si](C)(C)c1cc(C(O)COCCCc2ccc3ccccc3c2)co1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20150344446A1,NN.O=C(O)CCCc1cccc(Br)c1>>NNC(=O)CCCc1cccc(Br)c1,,C1CCOC1,,O,O=C(n1ccnc1)n1ccnc1,val
US20100168075A1,COc1ccc(C(=O)CS[C@H]2C(=O)N(c3ccc(F)cc3)[C@@H]2c2ccc(OCC(=O)NCC(=O)NC(CC(=O)O)C3CCCCC3)cc2)cc1>>COc1ccc(C(O)CS[C@H]2C(=O)N(c3ccc(F)cc3)[C@@H]2c2ccc(OCC(=O)NCC(=O)NC(CC(=O)O)C3CCCCC3)cc2)cc1,CC(=O)O,CO,,[BH4-].[Na+],,val
US20110218200A1,Nc1cc(N2CCN(C(=O)c3ccccc3)CC2)ccc1[N+](=O)[O-]>>Nc1ccc(N2CCN(C(=O)c3ccccc3)CC2)cc1N,[Pd],CCO,,CC(=O)O,,val
US20120157471A1,CS(=O)(=O)Cl.Cn1c(-c2nc(N3CCC(N)CC3)ncc2Cl)nc2ccccc21>>Cn1c(-c2nc(N3CCC(CS(N)(=O)=O)CC3)ncc2Cl)nc2ccccc21,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US06359134B1,CCOC(=O)c1nc(-c2ccncc2)cs1>>O=C(O)c1nc(-c2ccncc2)cs1,,CCO,,[Na+].[OH-],,val
US20110281859A1,CS(=O)(=O)Cl.OC[C@H]1CCCN1c1ccnc2ncnn12>>CS(=O)(=O)OC[C@H]1CCCN1c1ccnc2ncnn12,,ClCCl,,CCN(CC)CC,O,val
US20140163025A1,COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(O)ccc(F)c43)ccc21.Fc1ccnc(Br)c1>>COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccnc(Br)c5)ccc(F)c43)ccc21,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150087663A1,CC[C@H](N)c1nc2cccc(F)c2c(=O)n1-c1ccccc1.Cn1nnc(-c2c(N)ncnc2Cl)n1>>CC[C@H](Nc1ncnc(N)c1-c1nnn(C)n1)c1nc2cccc(F)c2c(=O)n1-c1ccccc1,,CCCCO,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20140194386A1,COc1c(C[C@H](NC(=O)c2ccc(CN(C)C)c(NC(=O)[C@H](CNC(=O)OC(C)(C)C)NC(=O)OCc3ccccc3)c2)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)OC(C)(C)C>>COc1c(C[C@H](NC(=O)c2ccc(CN(C)C)c(NC(=O)[C@@H](N)CNC(=O)OC(C)(C)C)c2)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)OC(C)(C)C,[Pd],CO,,,,val
US04472547,C1CO1.CC1(C)CC(N2CCCCCC2=O)CC(C)(C)N1>>CC1(C)CC(N2CCCCCC2=O)CC(C)(C)N1CCO,,CN(C)C=O,,,,val
US20160158207A1,CN1CCN(c2nn(C3CCOCC3)c3c2CN(C(=O)OC(C)(C)C)CC3)c2cc(C(F)(F)F)c(-c3cnn(C)c3)cc21>>CN1CCN(c2nn(C3CCOCC3)c3c2CNCC3)c2cc(C(F)(F)F)c(-c3cnn(C)c3)cc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090156607A1,CCCC1CC(=O)N(CCl)C1.Clc1cn2cc(Cl)sc2n1>>CCCC1CC(=O)N(Cc2c(Cl)nc3sc(Cl)cn23)C1,,C1COCCO1,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20090105295A1,CC(=O)Cl.CC(C)Cn1c(CON)nc2c(N)nc3c(c21)CCCC3>>CC(=O)NOCc1nc2c(N)nc3c(c2n1CC(C)C)CCCC3,,CCN(CC)CC,ClCCl,,,val
US05756532,COc1ccc(CN)cc1.Cc1ccc(S(=O)(=O)OC[C@H]2COc3ccc4c(c3O2)CC(=O)N4)cc1>>COc1ccc(CNCC2COc3ccc4c(c3O2)CC(=O)N4)cc1,,CS(C)=O,,O,,val
US20160235716A1,O=C1NC(=O)C2(CC(O)c3ccccc32)N1>>O=C1NC(=O)C2(C=Cc3ccccc32)N1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US05684022,BrCCBr.Oc1ccc(Cn2cccn2)cc1>>BrCCOc1ccc(Cn2cccn2)cc1,,O,,[Na+].[OH-],,val
US20090239864A1,CC(C)(C)OC(=O)[O-].CC(C)(C)OC(=O)[O-].N#Cc1ccc([C@H]2CNCCN2)cc1>>CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)[C@@H](c2ccc(C#N)cc2)C1,,C1CCOC1,,CCN(CC)CC,,val
US20100144760A1,C=Cc1nc(C)ccc1C(=O)OC.CC(N)=NO>>C=Cc1nc(C)ccc1-c1nc(C)no1,,C1CCOC1,,[H-].[Na+],,val
US04064259,C=CCCCCN.CCSc1ncc(C(=O)O)s1>>C=CCCCCNC(=O)c1cnc(SCC)s1,,C1CCOC1,,CCN(CC)CC,CCOC(=O)Cl,val
US20100113465A1,CC(C)(C)OC(=O)N1CCC2(CC1)CC(O)(c1ccc(F)c(Cl)c1)C2.CI>>COC1(c2ccc(F)c(Cl)c2)CC2(CCN(C(=O)OC(C)(C)C)CC2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20040067966A1,CCCn1c(=O)c2[nH]c(C34CCC(CCP(=O)(OCC)OCC)(CC3)CC4)nc2n(CCC)c1=O>>CCCn1c(=O)c2[nH]c(C34CCC(CCP(=O)(O)OCC)(CC3)CC4)nc2n(CCC)c1=O,,[Na+],[OH-],Cl,,val
US20150038488A1,C[C@@H](Oc1cc(B2OC(C)(C)C(C)(C)O2)cc2ncn(C3CC3)c12)[C@H]1CNC(=O)C1.Cc1nnc(Br)s1>>Cc1nnc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3c(c2)ncn3C2CC2)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,ClCCl,N#N,O=C([O-])[O-].[Na+].[Na+],val
US05849764,CN(C)C(=O)Cl.Cc1cc(C)cc(-c2[nH]c3ccc(N)cc3c2CCNC(=O)OC(C)(C)C)c1>>Cc1cc(C)cc(-c2[nH]c3ccc(NC(=O)N(C)C)cc3c2CCNC(=O)OC(C)(C)C)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US06936602B1,CCOC(=O)CC1(C)OCCO1>>CC1(CC(=O)O)OCCO1,,CO,,Cl,[Na+].[OH-],val
US20150018335A1,C[C@H]1CN(Cc2ccc(N3CCOCC3)cc2F)CCN1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OC(C(F)(F)F)C(F)(F)F>>C[C@H]1CN(Cc2ccc(N3CCOCC3)cc2F)CCN1C(=O)OC(C(F)(F)F)C(F)(F)F,CN(C)c1ccncc1,ClCCl,O,CCN(C(C)C)C(C)C,,val
US20070117836A1,CN(C)CCN1C(=O)c2cccc3cc(N)cc(c23)C1=O.S=C=Nc1ccc(Cl)cc1>>CN(C)CCN1C(=O)c2cccc3cc(NC(=S)Nc4ccc(Cl)cc4)cc(c23)C1=O,,CC#N,,,,val
US20070197506A1,CC(C)=CCBr.COC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C>>COC(=O)C1(CC=C(C)C)CCCN1C(=O)OC(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20040087588A1,CCOC(=O)CCBr.Cc1ccc(-c2nnn[nH]2)cc1>>CCOC(=O)CCn1nnc(-c2ccc(C)cc2)n1,,CCO,,C,C[O-].[Na+],val
US04777185,C=C[Mg]Br.OCC1(c2ccc(Cl)cc2)CC1>>C=CC(O)C1(c2ccc(Cl)cc2)CC1,,C1CCOC1,,[Cl-].[NH4+],,val
US20160024053A1,CSc1cn(-c2ncc(-c3ccccn3)cn2)c2cc(C(=O)N3C[C@@H]4C[C@H]3CN4C(=O)OC(C)(C)C)ccc12.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1cn(-c2ncc(-c3ccccn3)cn2)c2cc(C(=O)N3C[C@@H]4C[C@H]3CN4C(=O)OC(C)(C)C)ccc12,,ClCCl,,,,val
US20090143372A1,CC1(C)OB(c2cncc(CNCC3CC3)c2)OC1(C)C.CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(Br)cc23)CC1>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cncc(CNCC5CC5)c4)cc23)CC1,,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US04021564,CC(=O)OC1(C(=O)c2ccc(F)cc2)CCN(C)CC1.CCOC(=O)Cl>>Cl.O=C(c1ccc(F)cc1)C1(O)CCNCC1,,c1ccccc1,,,,val
US20140200231A1,C#CCCO.O=C(CCl)N1Cc2cnc(NC3Cc4ccccc4C3)nc2C1>>C#CCCOCC(=O)N1Cc2cnc(NC3Cc4ccccc4C3)nc2C1,,C1CCOC1,,[H-].[Na+],,val
US20150087646A1,CNc1cc(C)c(C)cc1N.COC(=O)c1ccc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)cc1OC>>COc1cc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)ccc1-c1nc2cc(C)c(C)cc2n1C,,Cc1ccccc1,,C[Al](C)C,,val
US20130116281A1,CC(C)(C)[Si](C)(C)Cl.CN(C)c1c(Br)cc2ccc(CO)nc2c1C#N>>CN(C)c1c(Br)cc2ccc(CO[Si](C)(C)C(C)(C)C)nc2c1C#N,,CN(C)C=O,,c1c[nH]cn1,,val
US20110118322A1,COC(=O)c1cccc(COc2ccc(-c3cc(F)c(F)cc3OC)cc2)c1>>COc1cc(F)c(F)cc1-c1ccc(OCc2cccc(C(=O)O)c2)cc1,,CO,,[K+].[OH-],,val
US20080176862A1,CN1C(=O)C(c2ccc(OC(F)F)cc2)(c2ccc(F)c(Br)c2)N=C1N.COc1cc(OS(C)(=O)=O)cc(B2OC(C)(C)C(C)(C)O2)c1.Cl>>COc1cc(OS(C)(=O)=O)cc(-c2cc(C3(c4ccc(OC(F)F)cc4)N=C(N)N(C)C3=O)ccc2F)c1.Cl,,CCOCC,ClCCl,,,val
US06177440B1,CI.CO.O=C([O-])OCCc1cc([N+](=O)[O-])c(F)cc1Cl>>COc1cc([N+](=O)[O-])c(F)cc1Cl,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060264407A1,CC(CCC(CO)C(C)CC(C)(C)C)CC(C)(C)C.O=P(Cl)(Cl)Cl>>CC(CCC(COP(=O)(Cl)Cl)C(C)CC(C)(C)C)CC(C)(C)C,,Cc1ccccc1,,CCN(CC)CC,,val
US20150210682A1,CCOc1ccc(Br)c(CC(CC)NC=O)c1>>CCOc1ccc(Br)c2c1C=NC(CC)C2,,CC#N,,O=P(Cl)(Cl)Cl,,val
US20110201603A1,Cc1cc(C(O)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1cccc([N+](=O)[O-])c1>>Cc1cc(C(O)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1cccc(N)c1,,CCO,,Cl,,val
US03984465,CCC(C)C(=O)Cl.COc1cccc(Cl)c1Cl>>CCC(C)C(=O)c1ccc(OC)c(Cl)c1Cl,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20110021506A1,O=C(O)N[C@@H]1CC[C@@H](CCC(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)CC1.O=[N+]([O-])c1ccc(F)cc1C(F)(F)F>>O=C(CC[C@@H]1CC[C@@H](Nc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)CC1)N1CCN(c2ccc(C(F)(F)F)cc2)CC1,,CS(C)=O,ClCCl,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20110021522A1,Nc1cccc(-c2ccccc2S(=O)(=O)N2CCOCC2)c1.O=C(O)c1cc2cccc(OC(F)(F)F)c2oc1=O>>O=C(Nc1cccc(-c2ccccc2S(=O)(=O)N2CCOCC2)c1)c1cc2cccc(OC(F)(F)F)c2oc1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140171404A1,COc1ccc(Cn2cc(CCCCO)nn2)cc1>>COc1ccc(Cn2cc(CCCC=O)nn2)cc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US09249115B2,CC(C)(C)OC(=O)N1CCNCC1.COc1ccc(C=O)cc1C(C)(C)C>>COc1ccc(CN2CCN(C(=O)OC(C)(C)C)CC2)cc1C(C)(C)C,CC(=O)O,ClCCl,,O=C([O-])O.[Na+],,val
US06350749B1,CC(O)CCN.O=C1CC(=O)CC(c2ccccc2)C1>>CCc1c[nH]c2c1C(=O)CC(c1ccccc1)C2,,C1CCOC1,,,,val
US20150166523A1,C/C(=C\c1ccn(-c2ccc(F)cn2)n1)[N+](=O)[O-]>>CC(N)Cc1ccn(-c2ccc(F)cn2)n1,,C1CCOC1,,O=S(=O)([O-])[O-].[Na+].[Na+],,val
US20110294807A1,Cc1cc(C=O)cc(C)c1OCCO.Nc1ccccc1C(=O)Nc1ccc(Br)cc1>>Cc1cc(-c2nc3ccccc3c(=O)n2-c2ccc(Br)cc2)cc(C)c1OCCO,Cl[Cu]Cl,CCO,,,,val
US20120184553A1,COC(=O)c1cc(S(=O)(=O)N2CCN(C)CC2)ccc1O.OCc1ccccc1>>COC(=O)c1cc(S(=O)(=O)N2CCN(C)CC2)ccc1OCc1ccccc1,,CCOCC,Cc1ccccc1,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06525204B1,CCCCON=O.Cc1c(C(=O)N(c2ccccc2)c2ccccc2)ccc(S(C)(=O)=O)c1C>>Cc1c(C(=O)N(c2ccccc2)c2ccccc2)ccc(S(C)(=O)=O)c1NO,,CC(=O)O,CN(C)C=O,O,CC(C)(C)[O-].[K+],val
US05025036,O=C(O)c1ccc(OCCCCCCc2cccc(OCc3ccccc3)c2OCc2ccccc2)c(Cl)c1>>O=C(O)c1ccccc1,[Pd],C1CCOC1,,[H][H],,val
US05700806,CSc1ccnc2c1CCc1cc(Cl)ccc1C2=C1CCN(C(=O)Cc2cccnc2)CC1.OO>>CS(=O)c1ccnc2c1CCc1cc(Cl)ccc1C2=C1CCN(C(=O)Cc2cccnc2)CC1,,C1CCOC1,,,,val
US20120309796A1,CC(C)(C)OC(=O)COc1cccc2c1CCCCC2N.O=S(=O)(Cl)c1cccc(-c2ccccc2)c1>>CC(C)(C)OC(=O)COc1cccc2c1CCCCC2NS(=O)(=O)c1cccc(-c2ccccc2)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160039780A1,O=Cc1cc(F)ccc1Oc1ccccc1>>OCc1cc(F)ccc1Oc1ccccc1,,CO,,[BH4-].[Na+],,val
US20050222145A1,CCC(C)(C)CC[C@H](NC(=O)N1CCOCC1)C(=O)O.COCCCN1CCC(N)(C#N)CC1>>CCC(C)(C)CC[C@H](NC(=O)N1CCOCC1)C(=O)NC1(C#N)CCN(CCCOC)CC1,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US20110224191A1,CC(c1c(Cl)cccc1Cl)c1c[nH]c2ncc(Br)cc12.CC1(C)OB(c2cnn(C3CCNCC3)c2)OC1(C)C>>CC(c1c(Cl)cccc1Cl)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12,,COCCOC,O,Cl,O=C([O-])[O-].[K+].[K+],val
US04385925,CC1(C(=O)Cn2cncn2)COCOC1.ClCc1ccc(Cl)cc1>>CC1(C(=O)C(Cc2ccc(Cl)cc2)n2cncn2)COCOC1,,CN(C)C=O,,[H-].[Na+],,val
US20050250792A1,NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1.O=C(O)CCc1nnc(-c2ccccc2)o1.O=C([O-])O>>CC(=O)O.O=C(Cc1nnc(-c2ccccc2)o1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US20110144087A1,CN(C)CCN1C(=O)[C@H](O)[C@H](c2ccc(O)cc2)Sc2ccccc21.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CN(C)CCN1C(=O)[C@H](O)[C@H](c2ccc(OS(=O)(=O)C(F)(F)F)cc2)Sc2ccccc21,,ClCCl,,CCN(CC)CC,,val
US20040116475A1,COc1ccc(-n2nc(OCC(F)(F)F)cc2-c2ccc(C#N)cc2)cn1>>COc1ccc(-n2nc(OCC(F)(F)F)cc2-c2ccc(CN)cc2)cn1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160083400A1,NO.O=C1CCc2ccccc21>>O/N=C1\CCc2ccccc21,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20080312226A1,Cc1cccc(N=C=O)c1.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>Cc1cccc(NC(=O)N2CCN(c3nc(-c4ccccc4)ns3)CC2)c1,,C1CCOC1,,CCN(CC)CC,,val
US20150291595A1,BrB(Br)Br.COc1cc(NC(=O)c2c(N)ncnc2Cl)ccc1-c1cnco1>>Nc1ncnc(Br)c1C(=O)Nc1ccc(-c2cnco2)c(O)c1,,ClCCl,,BrBr,,val
US20160145202A1,CNC(=O)Cl.OCc1cc(Br)ccc1Cl>>CNC(=O)OCc1cc(Br)ccc1Cl,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20120302599A1,CCOC(=O)c1cn(Cc2ccccc2)nc1[N+](=O)[O-]>>O=[N+]([O-])c1nn(Cc2ccccc2)cc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080280917A1,C#CCn1nc(-c2cccs2)ccc1=O.Nc1cc(Cl)ncc1I>>Nc1cc(Cl)ncc1C#CCn1nc(-c2cccs2)ccc1=O,,CC#N,ClCCl,CCN(CC)CC,CO,val
US20030087931A1,Cc1cc(N(C)C)c2cc(N)ccc2n1.Clc1nc(Cl)nc(Cl)n1>>Cc1cc(N(C)C)c2cc(Nc3nc(Cl)nc(Cl)n3)ccc2n1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20020019539A1,COC(=O)C(C)(C)N=C=O.NC[C@H](COc1ccc(Br)cc1)NOCc1ccccc1>>CC1(C)NC(=O)N(C[C@H](COc2ccc(Br)cc2)NOCc2ccccc2)C1=O,,C1CCOC1,,,,val
US20100144655A1,COC(=O)Cl.Clc1ncnc2[nH]cc(Br)c12>>COC(=O)c1c[nH]c2ncnc(Cl)c12,,C1CCOC1,,,,val
US20080015191A1,COc1cc(Nc2cncc(Oc3ccc(N)cc3)n2)cc(OC)c1OC.O=C(Cl)c1ccc(C(F)(F)F)cc1>>COc1cc(Nc2cncc(-c3ccc(C(=O)c4ccc(C(F)(F)F)cc4)cc3N)n2)cc(OC)c1OC,,CCOC(C)=O,,,,val
US20070185171A1,CC(C)(C)OC(=O)N1CCC[C@H]1CO.Nc1cccc(C(O)(C(F)(F)F)C(F)(F)F)c1>>CC(C)(C)OC(=O)N1CCC[C@H]1COC(c1cccc(N)c1)(C(F)(F)F)C(F)(F)F,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150344483A1,COC(OC)c1ccncc1OCc1ccc(C#N)cn1.O=C(O)C(F)(F)F>>N#Cc1ccc(COc2cnccc2C=O)nc1.O=C(O)C(F)(F)F,,ClCCl,,CS(C)=O,,val
US20010020112A1,CC(=O)CCC(C(=O)[O-])C(=O)c1ccccc1.CCOC(C)=O>>CCOC(=O)C1CCC(=O)C=C1c1ccccc1,C1CCNCC1,Cc1ccccc1,,CC(=O)O,,val
US20120010182A1,O=C1CCC(=O)N1I.Oc1ccc(-c2ccc(Cl)c(C(F)(F)F)c2)cc1>>Oc1ccc(-c2ccc(Cl)c(C(F)(F)F)c2)cc1I,,CC(=O)O,,O=S(=O)(O)O,,val
US05552534,CO[C@@H]1O[C@H](COCCCCCNC(=O)C(F)(F)F)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1>>CO[C@@H]1O[C@H](COCCCCCN)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1,,CCO,,Cl,,val
US20090306133A1,CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CN)CC1.O=C(O)c1cc(-c2ccc(F)nc2)nc2ccccc12>>CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CNC(=O)c2cc(-c3ccc(F)nc3)nc3ccccc23)CC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120083475A1,CC1(C)OC(=O)C2(CC2)C(=O)O1.Cc1ccc(N)cc1C>>Cc1ccc(N2CCC(C(=O)O)C2=O)cc1C,,CCO,,,,val
US20060074056A1,CCCC[Sn](CCCC)(CCCC)c1cc2nccc(Cl)c2s1.O[C@H]1CCN(Cc2ccc(Br)cc2)C1>>O[C@H]1CCN(Cc2ccc(-c3cc4nccc(Cl)c4s3)cc2)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCOC(C)=O,CO,val
US04775761,CN1CCC(c2n[nH]c3ccccc23)CC1.Cc1ccc(C(=O)Cl)cc1.O=C(O)/C=C/C(=O)O>>Cc1ccc(C(=O)n2nc(C3CCN(C)CC3)c3ccccc32)cc1.O=C(O)/C=C/C(=O)O,,CCO,CCOCC,[NH4+].[OH-],,val
US20130102527A1,CON(C)C(=O)[C@@H](N)Cc1ccc(NC(=O)OC(C)(C)C)cc1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CON(C)C(=O)[C@H](Cc1ccc(NC(=O)OC(C)(C)C)cc1)NC(c1ccccc1)(c1ccccc1)c1ccccc1,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20120115903A1,CI.COc1ccc2[nH]cc(CC(=O)O)c2c1>>COC(=O)Cc1c[nH]c2ccc(OC)cc12,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US05631373,Cc1cc2[nH]c(=O)c(=O)[nH]c2cc1C.O=[N+]([O-])O>>Cc1cc2[nH]c(=O)c(=O)[nH]c2c([N+](=O)[O-])c1C,,O=S(=O)(O)O,,,,val
US20070053831A1,CC(=O)c1cc2ccc(N(C)CCO)cc2oc1=O.Cc1ccc(S(=O)(=O)OS(=O)(=O)c2ccc(C)cc2)cc1>>CC(=O)c1cc2ccc(N(C)CCOS(=O)(=O)c3ccc(C)cc3)cc2oc1=O,,c1ccncc1,,,,val
US03931181,COc1cc(Cc2cnc(N)nc2N)cc(OC)c1C(=O)CS(C)(=O)=O>>COc1cc(Cc2cnc(N)nc2N)cc(OC)c1C(C)=O,,C1CCOC1,,[Al],,val
US20140206663A1,Cc1cc2c(cc1[N+](=O)[O-])N1C(=NNC(=O)C1C)CO2>>Cc1cc2c(cc1N)N1C(=NNC(=O)C1C)CO2,[Zn],C1CCOC1,CO,[Cl-].[NH4+],,val
US20090203688A1,Clc1ncc2cc[nH]c2n1.O=S(=O)(Cc1ccc(Br)cc1)Cc1ccc(Br)cc1>>CS(=O)(=O)c1ccc(-n2ccc3cnc(Cl)nc32)cc1,[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20100137362A1,CC(C)(C)OC(=O)Nc1ccc(Cl)nc1.CI>>Cc1cc(Cl)ncc1NC(=O)OC(C)(C)C,,CCOCC,,[Li]CCCC,,val
US06060482,Cl.O=C1NCN(c2ccccc2)C12CCN(CC1CCc3ccccc3O1)CC2>>Cl.O=C1NCN(c2ccccc2)C12CCN(CC1CCc3ccccc3O1)CC2,,CCOCC,ClCCl,,,val
US20080139539A1,CC[Al](C#N)CC.O=CC1CCN(Cc2ccccc2)CC1>>N#CC(O)C1CCN(Cc2ccccc2)CC1,,C1CCOC1,,,,val
US06136823,CCOC(=O)c1cn(-c2cc(N)c(F)cc2F)c2c(Cl)c(F)c(F)c(C)c2c1=O>>Cc1c(F)c(F)c(Cl)c2c1c(=O)c(C(=O)O)cn2-c1cc(N)c(F)cc1F,,Cl,,,,val
US06043360,COc1ccc(C(=O)C(O)c2ccc(OC)cc2)cc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COc1ccc(-c2cc3ccc(OC)cc3s2)cc1,,Clc1ccccc1,,CS(=O)(=O)O,,val
US20160214974A1,CC(C)(C)OC(=O)N1[C@H]2C=C[C@@H]1CC(C#N)C2.Fc1cncc(F)c1>>CC(C)(C)OC(=O)N1[C@H]2C=C[C@@H]1CC(C#N)(c1cncc(F)c1)C2,,C1CCOC1,C1CCOC1,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20100298377A1,C[Si](C)(C)CCOCCl.O=[N+]([O-])c1ccc2[nH]ncc2c1>>C[Si](C)(C)CCOCn1ncc2cc([N+](=O)[O-])ccc21,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20070093480A1,CCCCOB(OCCCC)OCCCC.COc1cc(OC)c2c(c1)c(I)cn2C(=O)O.[Li]CCCC>>COc1cc(OC)c2c(c1)c(B(O)O)cn2C(=O)OC(C)(C)C,,C1CCOC1,,CCCCCC,,val
US20070032481A1,Cc1cc(-c2nc(C(C)C)nc3c2CCN(Cc2ccccc2)C3)cs1.Cl>>Cc1cc(-c2nc(C(C)C)nc3c2CCNC3)cs1.Cl,,ClCCCl,,CC(Cl)OC(=O)Cl,,val
US20150104384A1,COC(=O)c1cc2ccncc2s1>>O=C(O)c1cc2ccncc2s1,,O,,Cl,[Na+].[OH-],val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.O=C(O)c1c(O)c(-c2ccccc2)nc2ccc(F)cc12>>COc1cc2nccc(Oc3cc4cc(F)ccc4nc3-c3ccccc3)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,O,,val
US20090142297A1,CC1(N)CCC(=O)NC1=O.COC(=O)c1ccc(Br)cc1CBr>>CC1(N2Cc3cc(Br)ccc3C2=O)CCC(=O)NC1=O,,CN(C)C=O,,Br,CCN(CC)CC,val
US20070208017A1,BrCC1CC1.O=C1C(=O)c2ccc(Br)cc2-c2cc(O)ccc21>>O=C1C(=O)c2ccc(OCC3CC3)cc2-c2cc(Br)ccc21,,CC(C)=O,,[I-].[K+],,val
US05914328,C=O.CC(C)(C)OC(=O)N1CCC[C@H]1COc1ccc(Cl)nc1>>CN1CCC[C@H]1COc1ccc(Cl)nc1,,O=CO,,,,val
US20130005707A1,COC(=O)c1ccc(Br)cc1CBr.COCCN>>COCCN1Cc2cc(Br)ccc2C1=O,,CO,,,,val
US20040082570A1,BrCc1ccccc1.Cl.Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1>>Cl.Nc1nc2ncn(Cc3ccccc3)c2c(=O)[nH]1,,CS(C)=O,,CO,,val
US20060128774A1,C=C(C)C(=O)Cl.CC1CN2CC(C)OC2(CCCCCO)O1>>C=C(C)C(=O)OCCCCCC12OC(C)CN1CC(C)O2,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20100016282A1,C[C@@H]1NCCN(CCCN2CCCCC2)C1=O.Nc1cccc(-c2ccccc2)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C[C@H]1C(=O)N(CCCN2CCCCC2)CCN1C(=O)Nc1cccc(-c2ccccc2)c1,,CC#N,,c1ccncc1,,val
US20090099190A1,CSc1ncc(CCl)c(NC(C)C)n1.N#Cc1cc(N)cc([N+](=O)[O-])c1>>CSc1ncc(CNc2cc(C#N)cc([N+](=O)[O-])c2)c(NC(C)C)n1,,CC#N,,CCN(C(C)C)C(C)C,[I-].[Na+],val
US20060247178A1,CC(C)(C)OC(=O)N1CCC(=O)C(Br)C1.CC(C)(C)[Si](OCCC1(c2ccccc2)SC(c2cc(F)ccc2F)=NN1C(N)=S)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N1CCc2nc(N3N=C(c4cc(F)ccc4F)SC3(CCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)c3ccccc3)sc2C1,,CCO,,CCN(C(C)C)C(C)C,,val
US20100009975A1,O=[N+]([O-])c1ccc2c(c1)SCCN2CCN1CCCC1>>Nc1ccc2c(c1)SCCN2CCN1CCCC1,[Ni],CO,,NN,O,val
US20160046624A1,CC(C)Oc1cnc2c(c1C(O)c1ccccc1)c(=O)n(CCCOC1CCCCO1)c(=O)n2C.O=CO>>CC(C)Oc1cnc2c(c1Cc1ccccc1)c(=O)n(CCCOC=O)c(=O)n2C,[Zn],O=CO,,,,val
US20140121197A1,F[C@@H]1CCNC1.O=C(Cl)CCl>>O=C(CCl)N1CC[C@@H](F)C1,,ClCCl,,CCN(CC)CC,O,val
US20140315881A1,CCOC(=O)C(C)(C)Br.Cc1ccc(C(NC(=O)Cc2ccc3oc(C(O)c4c(C)noc4C)cc3c2)c2ccccc2)c(C)c1>>Cc1ccc(C(NC(=O)Cc2ccc3oc(C(OC(C)(C)C(=O)O)c4c(C)noc4C)cc3c2)c2ccccc2)c(C)c1,,CC#N,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20040127574A1,NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)c(F)c1.O=C(Cl)CCc1ccccc1>>O=C(CCc1ccccc1)NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)c(F)c1,,CCOC(C)=O,O,O=C([O-])O.[Na+],,val
US20110098290A1,COC(=O)c1cc(C(C)C)c(OC)cc1O>>COc1cc(O)c(C(C)C)cc1C(=O)O,,O,,CO,[K+].[OH-],val
US04939241,CC(=O)O[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)OC[C@H](NC(=O)C(F)(F)F)C(=O)OCc1ccccc1>>CC(=O)O[C@H](C)[C@H](N)C(=O)OC[C@H](NC(=O)C(F)(F)F)C(=O)O,[Pd],CC(=O)O,,,,val
US20090240052A1,CC(C)(C)OC(=O)c1ccc(CCc2ccccc2)cc1NC(=O)c1ccc(-n2cccc2)nc1>>O=C(Nc1cc(CCc2ccccc2)ccc1C(=O)O)c1ccc(-n2cccc2)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04507315,Nc1ccccc1C(=O)NCCCn1ccnc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=C(NCCCn1ccnc1)c1ccccc1NS(=O)(=O)c1ccc(Cl)cc1,,O,,O=C([O-])O.[Na+],,val
US20070072847A1,CC(C)(C)OC(=O)COC1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1>>CC(C)(C)OC(=O)COC1CCN(C2CCNCC2)CC1,[Pd],CO,,[H][H],,val
US04079179,CO[C@]12SCC(COC(C)=O)=C(C(=O)OCc3ccc([N+](=O)[O-])cc3)N1C(=O)C2N=[N+]=[N-]>>CO[C@]12SCC(COC(C)=O)=C(C(=O)OCc3ccc([N+](=O)[O-])cc3)N1C(=O)[C@H]2N,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20150133446A1,CO.CS(=O)(=O)c1nn2cc(-c3nc4ccccc4o3)nc2s1>>COc1nn2cc(-c3nc4ccccc4o3)nc2s1,,CO,,C[O-].[Na+],,val
US20110144081A1,CN[C@H]1CN(C(=O)C2CCN(C(=O)C3(C)CC3)CC2)C[C@@H]1c1ccc(Cl)cc1.Nc1ccc(F)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN(C(=O)Nc1ccc(F)cc1)[C@H]1CN(C(=O)C2CCN(C(=O)C3(C)CC3)CC2)C[C@@H]1c1ccc(Cl)cc1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,ClCCl,val
US20130065906A1,N=C(NO)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1.O=C(Cl)c1ccccc1>>O=C(c1ccc(-c2cnco2)cc1)N(C1CC1)C1CCN(c2noc(-c3ccccc3)n2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20120220590A1,C=CCOc1cc(Oc2ccc(C=O)cc2)cc(C(=O)OC)c1.Cc1c(N)cccc1[N+](=O)[O-]>>C=CCOc1cc(Oc2ccc(CNc3cccc([N+](=O)[O-])c3C)cc2)cc(C(=O)OC)c1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100120672A1,Cn1ccnc1C1(O)CCN(C(=O)OC(C)(C)C)CC1>>Cn1ccnc1C1=CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CS(=O)(=O)Cl,,val
US04452809,CN(C)C(=O)N1C[C@@H](Oc2ccc(Cl)cc2)[C@H](O)C1.CN=C=O>>CNC(=O)O[C@@H]1CN(C(=O)N(C)C)C[C@H]1Oc1ccc(Cl)cc1,,ClCCl,,,,val
US06251919B1,CC(C)=CCN(c1ccc(OCc2ccccc2)cc1)C1CCN(C(=O)OC(C)(C)C)CC1.CC(C)=CCN(c1ccc(OCc2ccccc2)cc1)C1CCNCC1>>CC(C)=CCN(c1ccc(OCc2ccccc2)cc1)C1CCN(CCC(C)C)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05175337,CC(C)(C)CO.Cc1ccccc1.N#CCC(=O)O>>C=C(C#N)C(=O)OCC(C)(C)C,O=S(=O)(O)O,O,,,,val
US20150336949A1,COc1ncc(-c2cnc3c(c2)c(I)cn3C(=O)OC(C)(C)C)cc1N(C(=O)OC(C)(C)C)S(C)(=O)=O.Cc1nn(Cc2cccc(F)c2)c(C)c1B1OC(C)(C)C(C)(C)O1>>COc1ncc(-c2cnc3c(c2)c(-c2c(C)nn(Cc4cccc(F)c4)c2C)cn3C(=O)OC(C)(C)C)cc1NS(C)(=O)=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090018103A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[Si](C)(C)CCOC(=O)NC[C@@H](N)CC1CCCCC1>>CC(C)(C)OC(=O)N[C@H](CNC(=O)OCC[Si](C)(C)C)CC1CCCCC1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20080076924A1,CC(=O)Nc1ccc(C(=O)C=O)cc1.NCCN>>CC(=O)Nc1ccc(C2CNCCN2)cc1,,CCO,,O,[BH4-].[Na+],val
US20110251181A1,CC(C)(C)OC(=O)N1CCC(C(O)c2ccc(Cl)cc2)CC1.CN(C)CCCl>>CN(C)CCOC(c1ccc(Cl)cc1)C1CCN(C(=O)OC(C)(C)C)CC1,,CCOC(C)=O,CN(C)C=O,Cl,[H-].[Na+],val
US04975439,CO[C@@H]1CN(CCCC(=O)N2CCCC2)CC[C@@H]1NCc1ccccc1>>CO[C@@H]1CN(CCCC(=O)N2CCCC2)CC[C@@H]1N,[Pd],CO,,[H][H],,val
US04737514,NC(=O)c1ccc2c(c1)S(=O)(=O)c1ccc(F)cc1C2=O>>N#Cc1ccc2c(c1)S(=O)(=O)c1ccc(F)cc1C2=O,,CN(C)C=O,,O=S(Cl)Cl,,val
US20070043040A1,CC(C)(C)OC(=O)NCCNS(=O)(=O)c1cc(-c2ccccc2)cc2cnccc12.Cl.ClCCl>>Cl.Cl.NCCNS(=O)(=O)c1cc(-c2ccccc2)cc2cnccc12,,C1COCCO1,ClCCl,CO,,val
US20070082912A1,CC(=O)CCC(=O)c1cc(Cl)ccc1OCc1ccc(F)cc1F.Nc1ccc(S(=O)(=O)NC(=O)c2ccccc2)cc1>>Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1ccc(S(=O)(=O)NC(=O)c2ccccc2)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150361031A1,N#CCC(=O)O.Nc1ccc2c(c1)S(=O)(=O)C=C2>>N#CCC(=O)Nc1ccc2c(c1)S(=O)(=O)C=C2,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05011932,CCOC(=O)NN.O=C(c1ccccc1)c1ccncc1>>CCOC(=O)NN=C(c1ccccc1)c1ccncc1,,CC(=O)O,,,,val
US20040023995A1,CC(=O)O[C@H](C)CCCCn1c(=O)c2c(C)cc(=O)[nH]c2n(C)c1=O>>Cc1cc(=O)[nH]c2c1c(=O)n(CCCC[C@@H](C)O)c(=O)n2C,,CO,,Cl,O=C([O-])O.[Na+],val
US20050244332A1,COc1cc(CC(=O)c2ccc3c(c2)C(O)CC(C)(C)O3)cc(OC)c1OC.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1cc(CC(=O)c2ccc3c(c2)C(OS(=O)(=O)c2ccc(C)cc2)CC(C)(C)O3)cc(OC)c1OC,CN(C)c1ccncc1,ClCCl,O,,,val
US20150005321A1,N#Cc1cnc2[nH]c(C(F)(F)F)cc2c1>>NCc1cnc2[nH]c(C(F)(F)F)cc2c1,,C1CCOC1,,CO,,val
US20130274483A1,ClCc1ccccc1.O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2C1(O)c1cc2c(cc1O)OCCO2>>O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2C1(O)c1cc2c(cc1OCc1ccccc1)OCCO2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04659362,CCC(=O)C1=C(O)CC(c2c(OC)nc(OC)nc2OC)CC1=O.CCON>>CCON=C(CC)C1=C(O)CC(c2c(OC)nc(OC)nc2OC)CC1=O,,CCO,O,Cl,[Na+].[OH-],val
US20110230497A1,C1CCOC1.CC(C)(C)OC(=O)N1CCC2(CC1C=O)OCCO2>>CCOC(=O)/C=C/C1CC2(CCN1C(=O)OC(C)(C)C)OCCO2,,C1CCOC1,,[H-].[Na+],,val
US20100303926A1,C1CCNC1.CCO[C@H](C)COCc1ccc([C@H]2[C@H](C=O)CN(C(=O)OC(C)(C)C)C[C@@H]2OCc2ccc3c(c2)N(CCCOC)CCO3)cc1>>CCO[C@H](C)COCc1ccc([C@H]2[C@H](CN3CCCC3)CNC[C@@H]2OCc2ccc3c(c2)N(CCCOC)CCO3)cc1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120010241A1,O=C1CCC(=O)N1Cl.c1ccc2ncc(-c3cccc4[nH]ncc34)cc2c1>>Clc1n[nH]c2cccc(-c3cnc4ccccc4c3)c12,,CN(C)C=O,,,,val
US05475109,CC(=O)C1(Cc2ccc(Cl)cc2)CCCNC1.ClCc1ccccc1>>CC(=O)C1(Cc2ccc(Cl)cc2)CCCN(Cc2ccccc2)C1,,CC#N,,Cl,O=C([O-])O.[Na+],val
US20050054704A1,CCN(CC)CC.CCOC(C)=O.CN(C)C=O.C[C@@]1(Cc2ccc(OC(F)(F)F)cc2)C(=O)N(c2cc(Cl)cc(Cl)c2)c2ncc(S(=O)(=O)Cl)n21>>C[C@@]1(Cc2ccc(OC(F)(F)F)cc2)C(=O)N(c2cc(Cl)cc(Cl)c2)c2ncc(S(=O)(=O)N3CCC[C@H]3C(=O)NCCO)n21,,ClCCl,,,,val
US20090197926A1,COC(=O)C[C@@H]1CC[C@@H](c2ccc(NC(=O)C(=O)NN)c([N+](=O)[O-])c2)CC1.Fc1ccc(N=C=S)cc1F>>COC(=O)C[C@@H]1CC[C@@H](c2ccc(NC(=O)c3nnc(Nc4ccc(F)c(F)c4)o3)c([N+](=O)[O-])c2)CC1,,CC(=O)N(C)C,,CCN=C=NCCCN(C)C,,val
US20020035102A1,CN(C(=O)OC(C)(C)C)c1cccc(C(=C2CN(C(c3ccccc3)c3ccccc3)C2)S(C)(=O)=O)c1>>CNc1cccc(C(=C2CN(C(c3ccccc3)c3ccccc3)C2)S(C)(=O)=O)c1,,C1COCCO1,,,,val
US20030032804A1,CCN(CC)CC.OCCOCCOCCOCCOCCOCCOCc1ccccc1>>NC(COCCOCCOCCOCCOCCO)OCc1ccccc1,,ClCCl,,CS(=O)(=O)Cl,,val
US20020052322A1,CCOC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1)C(C)C>>CC(C)[C@H](NC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1)C(=O)O,,CO,ClC(Cl)Cl,,,val
US20070155805A1,CCCCC(CCSc1ccc(OCC(=O)OCC)c(C)c1)c1oc2cc(C)ccc2c1C>>CCCCC(CCSc1ccc(OCC(=O)O)c(C)c1)c1oc2cc(C)ccc2c1C,,C1CCOC1,CO,[Na+].[OH-],,val
US20110319394A1,CC(C)(C)OC(=O)Nc1ccc(Oc2nc3ccccc3n2COCC[Si](C)(C)C)cc1>>C[Si](C)(C)CCOCn1c(Oc2ccc(N)cc2)nc2ccccc21,,CCOC(C)=O,,Cl,,val
US04865837,CI.Cn1cnc(C=NO)n1>>Cn1c[n+](C)nc1C=NO.[I-],,C1CCOC1,CN(C)C=O,,,val
US20150166573A1,CCSc1ccncc1-c1nc2cc(C(F)(F)F)cnc2n1C.O=C(OO)c1cccc(Cl)c1>>CCS(=O)c1ccncc1-c1nc2cc(C(F)(F)F)cnc2n1C,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20070249670A1,COC(=O)[C@H](CCNC(=O)OC(C)(C)C)NC(=O)c1cc2ccccc2cc1N.Cc1cc(C)c(N=C=O)c(C)c1>>COC(=O)[C@H](CCNC(=O)OC(C)(C)C)NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C,,c1ccncc1,,,,val
US20030212290A1,C=C(C#N)C(O)C(C)C.CC(=O)Cl>>C=C(C#N)C(OC(C)=O)C(C)C,,ClCCl,O,Cl,c1ccncc1,val
US20080032968A1,CCOC(=O)c1cc2c(CN3CCN(C(=O)OC(C)(C)C)CC3)c(OC)ccc2n1S(=O)(=O)c1ccccc1.[Li+]>>COc1ccc2c(cc(C(=O)[O-])n2S(=O)(=O)c2ccccc2)c1CN1CCN(C(=O)OC(C)(C)C)CC1.[Li+],,C1CCOC1,,O,,val
US20040030137A1,COCc1cc(Br)c(C(=NO)C2CCN(C(=O)OC(C)(C)C)CC2)s1>>COCc1cc2onc(C3CCN(C(=O)OC(C)(C)C)CC3)c2s1,I[Cu]I,COCCO,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020193596A1,COC(=O)[C@@H](N)CC(C)(C)C(=O)c1cccc(NCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)c1-c1cccc2ccccc12>>CC(C)(C[C@H](N)C(=O)O)C(=O)c1cccc(NCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)c1-c1cccc2ccccc12,,C1CCOC1,O,[Li+].[OH-],,val
US20050288273A1,CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCC(C(=O)c2nnc(-c4ccccc4)o2)C3=O)C(=O)O1.NN>>CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCc2c(-c4nnc(-c5ccccc5)o4)n[nH]c2-3)C(=O)O1,,CCO,,O,,val
US20080227839A1,CC(C)CN.CON(C)C(=O)c1ccc([N+](=O)[O-])c(F)c1>>CON(C)C(=O)c1ccc([N+](=O)[O-])c(NCC(C)C)c1,,CC#N,,,,val
US20140148412A1,C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)O>>C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@@]43C)[C@@H]1CC[C@@H]2CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130345194A1,CC(C)(C)OC(=O)NS(=O)(=O)Cl.c1nc(N2CCNC3(CC3)C2)c2cc[nH]c2n1>>CC(C)(C)OC(=O)NS(=O)(=O)N1CCN(c2ncnc3[nH]ccc23)CC12CC2,,ClCCl,,CCN(CC)CC,,val
US20090118501A1,Cc1cnc(NC(=O)N(C2CCC(C)CC2)C2CCC3(CC2)OCCO3)s1>>Cc1cnc(NC(=O)N(C2CCC(=O)CC2)C2CCC(C)CC2)s1,,CC(=O)O,,,,val
US20020052396A1,CO.COC(OC)OC.O=Cc1ccc(Br)o1>>COC(OC)c1ccc(Br)o1,,CO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20110054017A1,COc1ccc(B(O)O)cc1.Cc1oc(-c2ccccc2)c(Br)c1C(=O)NC(C)CCCCC(=O)OC(C)(C)C>>COc1ccc(-c2c(-c3ccccc3)oc(C)c2C(=O)NC(C)CCCCC(=O)OC(C)(C)C)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CS(C)=O,,CO,O=C([O-])[O-].[K+].[K+],val
US06936602B1,CC1(CC(=O)O)OCCO1.CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCCOC4)cc2)CCN3)cc1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCCOC4)cc2)CCN3C(=O)CC2(C)OCCO2)cc1,,C1CCOC1,c1ccncc1,CN(C)C=O,O=S(Cl)Cl,val
US07160887B1,C[C@H](NC(=O)OC(C)(C)C)c1cccc(Oc2cc(Cl)ccc2N(CCCNC(=O)NCc2ccccc2F)C(=O)c2ccc(-c3ccccc3)cc2)c1.Cl>>C[C@H](N)c1cccc(Oc2cc(Cl)ccc2N(CCCNC(=O)NCc2ccccc2F)C(=O)c2ccc(-c3ccccc3)cc2)c1.Cl,,CCOC(C)=O,,,,val
US04113877,CC(C)(C)c1cc(I)c(O)c(CNC(=O)C(F)(F)F)c1.CN(C)S(=O)(=O)Cl>>CN(C)S(=O)(=O)Oc1c(I)cc(C(C)(C)C)cc1CNC(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20140274689A1,C(=NNc1ccccc1)/C(=N\Nc1ccccc1)c1ccco1>>c1ccc(-n2ncc(-c3ccco3)n2)cc1,,C1COCCO1,O,,,val
US20140275064A1,CC(C)(C)OC(=O)Nc1ccc([N+](=O)[O-])cc1C#N>>CC(C)(C)OC(=O)Nc1ccc(N)cc1C#N,[Pd],CCO,,O=C[O-].[NH4+],,val
US20010006969A1,CCCCN.Cc1csc2c(Cl)nc(Cl)nc12>>CCCCNc1nc(Cl)nc2c(C)csc12,,CN(C)C=O,,,,val
US20070167452A1,Cc1ccc(S(=O)(=O)OC[C@H](CO)CCC2CO2)cc1>>Cc1ccc(S(=O)(=O)OC[C@H]2CCC(CO)OC2)cc1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US06518257B1,CC(=O)Nc1ccc(B(O)O)cc1.CC(C)C(O)(c1ccc(Br)cc1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CC(=O)Nc1ccc(-c2ccc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US04820734,O=C1CCCCC1[C@@H](C[N+](=O)[O-])c1ccc(Cl)c(Cl)c1>>NC[C@@H](c1ccc(Cl)c(Cl)c1)[C@H]1CCCC[C@H]1O,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20130023514A1,COCC#CC(=O)[C@@H]1CC[C@@H](N(Cc2ccccc2)Cc2ccccc2)CC1.NN>>COCc1cc([C@@H]2CC[C@@H](N(Cc3ccccc3)Cc3ccccc3)CC2)n[nH]1,,CCO,,O,,val
US20090253758A1,Cc1c(N[C@@H](c2nnc(-c3ccc(NC(=O)c4ccccc4)cc3)o2)[C@H](C)O[Si](C)(C)C(C)(C)C)ccc(C#N)c1Cl>>Cc1c(N[C@@H](c2nnc(-c3ccc(NC(=O)c4ccccc4)cc3)o2)[C@H](C)O)ccc(C#N)c1Cl,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130040930A1,COC(=O)c1cnc(Cl)nc1.O=S1(=O)CCCN1>>COC(=O)c1cnc(N2CCCS2(=O)=O)nc1,,CN(C)C=O,,O,[H-].[Na+],val
US20150266916A1,CC(C)(C)C(=O)OCCl.CCOc1ccc(Cc2cc([C@]34OC[C@](C(C)O)(O3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]4OCc3ccccc3)ccc2Cl)cc1>>CCOc1ccc(Cc2cc([C@]34OC[C@](C(C)OC(=O)C(C)(C)C)(O3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]4OCc3ccccc3)ccc2Cl)cc1,,C1CCOC1,,[H-].[Na+],,val
US05472964,CS(=O)(=O)Cl.Cc1nc2ccc(CO)nc2s1>>Cc1nc2ccc(COS(C)(=O)=O)nc2s1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US05591762,CCCCc1nc2c(C)ccc(OCCN3CNC4CC=CC=C43)c2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCCc1nc2c(C)ccc(OCCN3CNC4CC=CC=C43)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05708008,CN1CCC(=O)CC1.CS(=O)(=O)Nc1ccc2[nH]ccc2c1>>CN1CC=C(c2c[nH]c3ccc(NS(C)(=O)=O)cc23)CC1,,CO,,[K+].[OH-],,val
US20140221311A1,Clc1ncccc1Br.OC1CCSCC1>>Brc1cccnc1OC1CCSCC1,,CN(C)C=O,,[H-].[Na+],,val
US20110301181A1,COC(=O)c1cc(O)nn1C.Cc1ccc(S(=O)(=O)OCC(F)(F)F)cc1>>COC(=O)c1cc(OCC(F)(F)F)nn1C,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04259338,C#CCBr.Cc1oc2ccc(C3CCNCC3)cc2c1C>>C#CCN1CCC(c2ccc3oc(C)c(C)c3c2)CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20030195221A1,CSc1nc(-c2ccnc(Cl)c2)c(-c2cccc(C(F)(F)F)c2)c(=O)n1C.O=P(Cl)(Cl)Cl>>CSc1nc(Cl)c(-c2cccc(C(F)(F)F)c2)c(-c2ccnc(Cl)c2)n1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US20150175601A1,CC(C)(C)OC(=O)N1CCC(N)CC1.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)N1CCC(Nc2ccc([N+](=O)[O-])cc2)CC1,,CS(C)=O,,,,val
US04988689,Cc1ccc(Cn2c(NC3CCCN(CCO)CC3)nc3cccnc32)o1.Clc1ncccn1>>Cc1ccc(Cn2c(NC3CCCN(CCOc4ncccn4)CC3)nc3cccnc32)o1,,CN(C)C=O,,O,[H-].[Na+],val
US20110015065A1,Cc1ccc(Oc2ccc(S(=O)(=O)Cl)cc2)nc1.N>>Cc1ccc(Oc2ccc(S(N)(=O)=O)cc2)nc1,,C1COCCO1,,,,val
US05506258,CCOC(=O)[C@H](Cc1ccc(OC)cc1)NS(=O)(=O)c1ccc(Cl)c(Cl)c1>>COc1ccc(C[C@H](NS(=O)(=O)c2ccc(Cl)c(Cl)c2)C(=O)O)cc1,,CCO,,[K+].[OH-],,val
US20130237535A1,CC1(C)OB(c2ccc(S(=O)(=O)N3CCC4(CC3)CN(C3CC3)C(=O)CO4)cc2)OC1(C)C.COc1cnc2cc(Br)ccc2c1>>COc1cnc2cc(-c3ccc(S(=O)(=O)N4CCC5(CC4)CN(C4CC4)C(=O)CO5)cc3)ccc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US04419357,CCOC(C)(OCC)OCC.Nc1ccccc1C(=O)Nc1nnn[nH]1>>Cc1nc2ccccc2c(=O)n1-c1nnn[nH]1,,CCO,,,,val
US20100093731A1,CCOC(=O)CC1CCNCC1.COc1nc(Cl)nc(Nc2ccc(-n3cnc(C)c3)c(OC)c2)n1>>CCOC(=O)CC1CCN(c2nc(Nc3ccc(-n4cnc(C)c4)c(OC)c3)nc(OC)n2)CC1,,CO,,CCN(CC)CC,Cl,val
US20050070508A1,Brc1ccncc1.O=C(NCCN1CCOCC1)c1cccc2cc(O)ccc12>>O=C(NCCN1CCOCC1)c1cccc2cc(Oc3ccncc3)ccc12,,CC(=O)N(C)C,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20150252038A1,CC(C)(C)OC(=O)N1CCC(O)C(C)(C)C1.FC(F)(F)c1cc(Cl)ncc1Cl>>CC(C)(C)OC(=O)N1CCC(Oc2cc(C(F)(F)F)c(Cl)cn2)C(C)(C)C1,,CCOC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140243334A1,COC(=O)C1CCc2ccc(N)cc2C1.O=C=Nc1ccccc1>>COC(=O)C1CCc2ccc(NC(=O)Nc3ccccc3)cc2C1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20020128301A1,CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)OCC(C)(C)CO.O=C(Cl)OCCl>>CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)OCC(C)(C)COC(=O)OCCl,,ClCCl,,c1ccncc1,,val
US05514812,CCCCC(=O)CC.NO>>CCCCC(CC)=NO,,CO,,Cl,,val
US20090163508A1,Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.Fc1ccc(-c2cc(N3CCNCC3)ccn2)c(F)c1>>Cc1noc(NC(=O)N2CCN(c3ccnc(-c4ccc(F)cc4F)c3)CC2)c1C,,CCCCCC,CCOC(C)=O,,,val
US20110301200A1,COc1ccc(O)cc1C(C)C.O=Cc1cc(Cl)c(I)c(Cl)c1>>COc1ccc(Oc2c(Cl)cc(C=O)cc2Cl)cc1C(C)C,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20050209217A1,CC(C)(C)OC(=O)N1CC[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@@H]1C=O.NCC(c1ccccc1)c1ccccc1>>CN(CC(c1ccccc1)c1ccccc1)[C@H]1[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)CCN1C(=O)OC(C)(C)C,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120046268A1,CCOC(=O)c1ccc(C2CNCC(NC(=O)c3ccccc3)C2)cc1.O=C(Cl)N1CCOCC1>>CCOC(=O)c1ccc(C2CC(NC(=O)c3ccccc3)CN(C(=O)N3CCOCC3)C2)cc1,,ClCCl,,CCN(CC)CC,O,val
US20100331372A1,CI.Clc1cccc(Cl)n1>>Cc1cc(Cl)nc(Cl)c1,,C1CCOC1,,[Li]CCCC,,val
US20010056094A1,COC(=O)Cc1ccc(C(F)(F)F)cc1[N+](=O)[O-]>>O=C1Cc2ccc(C(F)(F)F)cc2N1,[Pd],,,,,val
US04885367,O=[N+]([O-])c1ccccc1SC1CCCCC1>>Nc1ccccc1SC1CCCCC1,[Fe],O,,[Cl-].[NH4+],,val
US20110160056A1,CC(C)(C)C(O)C(CCCCCl)n1cncn1.Oc1ccc(Cl)c(Cl)c1>>CC(C)(C)C(O)C(CCCCOc1ccc(Cl)c(Cl)c1)n1cncn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060116396A1,Cc1ccc2c([N+](=O)[O-])cccc2n1>>Cc1ccc2c(N)cccc2n1,[Pd],CC(=O)O,,[H][H],,val
US20080207728A1,CC(=O)NC(Cc1c[nH]c2c(F)cc(F)cc12)(C(=O)O)C(=O)O>>CC(=O)NC(Cc1c[nH]c2c(F)cc(F)cc12)C(=O)O,,O,,,,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4ccc(C)nc4)cc2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4ccc(C)nc4)cc2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US04576749,COC(CN)OC.O=C(CBr)OCc1ccccc1>>COC(CNCC(=O)OCc1ccccc1)OC,,CCOCC,,,,val
US20160009720A1,CCI.O=c1[nH]c2ncc(Br)cc2o1>>CCn1c(=O)oc2cc(Br)cnc21,,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US07687510B2,CCOC(=O)CC(C)=O.N#Cc1ccc(C=O)cc1.NC(=O)Nc1ccc(F)cc1>>CCOC(=O)C1=C(C)N(c2ccc(F)cc2)C(=O)NC1c1ccc(C#N)cc1,,C1CCOC1,,Cl,,val
US20100168418A1,Cc1cc(=O)n(CCN2CCC(N(Cc3ccc4c(c3)OCCO4)C(=O)OC(C)(C)C)CC2)c2cc(C3CC3)ccc12.Cl>>Cc1cc(=O)n(CCN2CCC(NCc3ccc4c(c3)OCCO4)CC2)c2cc(C3CC3)ccc12.Cl,,CCOC(C)=O,,CO,,val
US20130331372A1,CCOC(C)=O.COc1ccc(C=O)c(F)c1>>CCOC(=O)CCc1ccc(OC)cc1F,,C1CCOC1,,[H-].[Na+],,val
US20090298823A1,CC(C)(CN)CN.Clc1nc(Cl)c2cc[nH]c2n1>>CC(C)(CN)CNc1nc(Cl)nc2[nH]ccc12,,CCCCO,,CCN(CC)CC,,val
US20090163586A1,NS(=O)(=O)c1ccc(F)cc1NS(=O)(=O)/C=C/c1ccc(Cl)cc1>>NS(=O)(=O)c1ccc(F)cc1NS(=O)(=O)CCc1ccc(Cl)cc1,[Pd],CCOC(C)=O,,[H][H],,val
US03944600,Br.CC(CN(C)C)C(=O)Br.Fc1ccccc1>>CC(C)(Br)C(=O)c1ccc(F)cc1,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080004285A1,CC(=O)Nc1nc(-c2nc[nH]n2)c2nc(-c3ccc(F)cc3)ccc2n1.Nc1ccccc1>>CC(=O)Nc1nc(Nc2ccccc2)c2nc(-c3ccc(F)cc3)ccc2n1,,C1COCCO1,,,,val
US20110053931A1,COc1ncnc(Cl)c1C.Nc1ccccc1>>Cc1c(Nc2ccccc2)nc[nH]c1=O,,CCCCO,,,,val
US20060252777A1,BrCc1ccccc1.COc1cc2c(Oc3ccc(N4C(=O)CNC4=O)cc3F)ccnc2cc1OCc1ccccc1>>COc1cc2c(Oc3ccc(N4C(=O)CN(Cc5ccccc5)C4=O)cc3F)ccnc2cc1OCc1ccccc1,,C1CCOC1,CN(C)C=O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20040024034A1,Cc1oc(-c2ccc(Br)cc2)nc1CC(=O)O>>Cc1oc(-c2ccc(Br)cc2)nc1CCO,,C1CCOC1,,,,val
US20100105650A1,COc1ccc(Cn2ccc3cc(S(=O)C4CCN(C(=O)OC(C)(C)C)CC4)c(Cl)cc3c2=O)cc1>>O=c1[nH]ccc2cc(S(=O)C3CCNCC3)c(Cl)cc12,,O=C(O)C(F)(F)F,,,,val
US20030087874A1,COc1ccc(Cn2c(=O)ccn([C@@H]3OC([C@H](O)[C@H](NCCCNC(=O)[C@H](CC(C)C)NC(=O)OCc4ccccc4)C(=O)OC(C)(C)C)[C@@H](O)[C@H]3O)c2=O)cc1>>COc1ccc(Cn2c(=O)ccn([C@@H]3OC([C@H](O)[C@H](NCCCNC(=O)[C@H](CC(C)C)NC(=O)OCc4ccccc4)C(=O)O)[C@@H](O)[C@H]3O)c2=O)cc1,,O=C(O)C(F)(F)F,,,,val
US05772990,C1CCNCC1.CCCNc1cc(Cl)nc(N)[n+]1[O-]>>CCCNc1cc(N2CCCCC2)nc(N)[n+]1[O-],,CCO,,[K+].[OH-],,val
US20090264445A1,CCOC(=O)C=C(C)Cl.Oc1cccc(F)c1F>>CCOC(=O)/C=C(\C)Oc1cccc(F)c1F,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US03962259,CCN1CCC(O)(c2ccccc2CO)CC1>>CCN1CCC2(CC1)OCc1ccccc12,,O=CO,,,,val
US05371086,CSC(=C[N+](=O)[O-])SC.Nc1ccncc1N>>CSC(=C[N+](=O)[O-])Nc1cnccc1N,,CCN(CC)CC,CN(C)C=O,,,val
US20050239829A1,COCCN.O=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>COCCNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120053173A1,CCOC(=O)CCNC(=O)c1ccc(NC(c2oc3ccc(OCc4ccccc4)cc3c2C)C2CCCCC2)cc1>>CCOC(=O)CCNC(=O)c1ccc(NC(c2oc3ccc(O)cc3c2C)C2CCCCC2)cc1,O=[Pt],CCO,,,,val
US20160184318A1,CC(C)(C)OC(=O)N1CCC(CCOS(C)(=O)=O)CC1.Cc1cn[nH]c1>>Cc1cnn(CCC2CCN(C(=O)OC(C)(C)C)CC2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20010047038A1,Cc1ccc(CCl)c(N)c1C.Cc1ccc2nc(S)[nH]c2c1>>Cc1ccc2[nH]c(SCc3ccc(C)c(C)c3N)nc2c1,,CC(C)O,,Cl,,val
US20100004450A1,CCOC(=O)N(CCCC1CCN(C)CC1)c1ncc(C#N)c(C)n1>>Cc1nc(NCCCC2CCN(C)CC2)ncc1C#N,,CO,,[Na+].[OH-],,val
US20080200483A1,N[C@H]1C[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(Cl)nc32)[C@H](O)[C@@H]1O.O=C(Cl)C1CC1>>O=C(N[C@H]1C[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(Cl)nc32)[C@H](O)[C@@H]1O)C1CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20160083312A1,Brc1nc2ccccc2s1.Oc1ccccc1I>>Ic1ccccc1Oc1nc2ccccc2s1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20090069288A1,N#Cc1ccc(N)cc1.O=C(Cl)c1cc(-c2ccccc2)c(C(F)(F)F)s1>>N#Cc1ccc(NC(=O)c2cc(-c3ccccc3)c(C(F)(F)F)s2)cc1,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US20070292352A1,COc1cc([C@@H]2c3cc4c(cc3[C@H](O)[C@H]3COC(=O)[C@@H]32)OCO4)cc(OC)c1OC.O=C1CCC(=O)O1>>COc1cc([C@@H]2c3cc4c(cc3[C@H](OC(=O)CCC(=O)O)[C@H]3COC(=O)[C@@H]32)OCO4)cc(OC)c1OC,,c1ccncc1,,,,val
US20060160879A1,CCOC(=O)c1c(NC(=O)c2ccc(Cl)cc2)c2ccc(-c3ccc(CO)cc3)cc2n1Cc1cccc(Cl)c1>>O=C(Nc1c(C(=O)O)n(Cc2cccc(Cl)c2)c2cc(-c3ccc(CO)cc3)ccc12)c1ccc(Cl)cc1,,CC#N,,[Na+].[OH-],,val
US20020169215A1,C=CC(=O)OCCCCO.CC(C)(Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1>>C=CC(=O)OCCCCOc1c(C(C)(C)C)cc(SC(C)(C)Sc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1C(C)(C)C,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100105904A1,COc1cc([N+](=O)[O-])ccc1Br.Cc1c[nH]cn1>>COc1cc([N+](=O)[O-])ccc1-n1cnc(C)c1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20140088117A1,C=CCCC=O.Cn1cc([N+](=O)[O-])cn1>>C=CCCC(O)c1c([N+](=O)[O-])cnn1C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120128630A1,COC(=O)[C@H](OC1=C(C(=O)c2ccc(C(C)C)cc2)[C@@H](c2ccc(OC(F)(F)F)cc2)N(c2ccc(C)nn2)C1=O)c1ccccc1>>Cc1ccc(N2C(=O)C(O)=C(C(=O)c3ccc(C(C)C)cc3)[C@H]2c2ccc(OC(F)(F)F)cc2)nn1,,CS(C)=O,,,,val
US20100216836A1,Oc1cccc([C@H]2CCCN(C[C@H]3COc4cc(OCc5ccccc5)ccc4O3)C2)c1>>Oc1cccc([C@H]2CCCN(C[C@H]3COc4cc(O)ccc4O3)C2)c1,[Pd],CCOC(C)=O,,CCOCC,,val
US20090203753A1,[N-]=[N+]=NC[C@H](O)c1ccc(OCc2ccccc2)c2[nH]c(=O)sc12>>NC[C@H](O)c1ccc(OCc2ccccc2)c2[nH]c(=O)sc12,[Pd],C1CCOC1,CCO,[H][H],,val
US20160168158A1,COc1ccc(Cn2nnc(C(N)=O)c2NC(=O)C2CC2)cc1>>COc1ccc(Cn2nnc3c(=O)[nH]c(C4CC4)nc32)cc1,,O,,,,val
US20090143596A1,COC(=O)c1cc(I)cc(C(=O)OC)c1.N#Cc1ccc(B(O)O)cc1>>COC(=O)c1cc(C(=O)OC)cc(-c2ccc(C#N)cc2)c1,[Pd],CO,,O=C([O-])[O-].[Na+].[Na+],,val
US20100204472A1,CCCc1cc(C(N)=S)ccc1OCCCOc1ccc2c(c1)CC[C@H]2CC(=O)OCC.O=C1OCCCC1Br>>CCCc1cc(-c2nc3c(s2)CCCO3)ccc1OCCCOc1ccc2c(c1)CC[C@H]2CC(=O)OCC,,CCO,,,,val
US20130261102A1,CC(C)(C)OC(=O)N1CCN(c2cnc3ccc(Cl)nc3c2)CC1>>Clc1ccc2ncc(N3CCNCC3)cc2n1,,CO,,CC(=O)Cl,,val
US20040209905A1,CC(=O)Cl.CCCNC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl>>CCCNC(=O)N(C(C)=O)c1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl,,C1CCOC1,,[H-].[Na+],,val
US20090036492A1,COc1cc(C=O)c2ccccc2c1.COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C>>COc1cc(O)c2c(c1C(=O)NCc1c(OC)ccc3ccccc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,,CC#N,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US09382228B2,O=[N+]([O-])c1ccc(Oc2ccnc(-c3ccc(C(F)(F)F)nc3)c2)cn1>>Nc1ccc(Oc2ccnc(-c3ccc(C(F)(F)F)nc3)c2)cn1,[Pd],CO,,,,val
US04960779,CC(=O)CCc1ccccc1.COc1ccc2ccc(N3C(=O)c4ccccc4C3O)nc2n1>>COc1ccc2ccc(N3C(=O)c4ccccc4C3CC(=O)CCc3ccccc3)nc2n1,,CN(C)C=O,,[H-].[Na+],,val
US20140088101A1,COC(=O)c1cc(Br)c(=O)n(Cc2ccc(OC)cc2)c1C.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Br)c(=O)n(Cc2ccc(OC)cc2)c1CBr,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20140275558A1,CC(=O)Cl.CCO.N#Cc1ccc(C(=O)O)cc1>>CCOC(=N)c1ccc(C(=O)O)cc1.Cl,,CCO,,,,val
US20070213336A1,CCCCCNC(=O)N(C)c1cccc(-c2ccc(/C=C/C(=O)OC)cc2[N+](=O)[O-])c1>>CCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)OC)cc2N)c1,[Pd],CO,,,,val
US20120101099A1,COC(=O)c1cccc(CNC(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)NCc1cccc(C(=O)O)c1,,C1CCOC1,O,[Li+].[OH-],,val
US05654322,CC(=O)OC(C)=O.Cc1nnc(N)s1>>CC(=O)Nc1nnc(C)s1,,CCN(CC)CC,,Cc1ccccc1,,val
US05488120,CC(C)[C@@H](C)CC[C@@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C>>C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@@]2(C)[C@H]1CC[C@@H]2[C@H](C)CC[C@H](C)C(C)C,,CCOCC,c1ccccc1,CCO,O,val
US06306852B1,COC(=O)C(c1cc(OC)c2c(c1)OCO2)c1c[nH]c2cc(Br)ccc12.COS(=O)(=O)c1ccc(C)cc1>>COC(=O)C(c1cc(OC)c2c(c1)OCO2)c1cn(C)c2cc(Br)ccc12,,CN(C)C=O,,[H-].[Na+],,val
US20120270879A1,CC(C)(C)OC(=O)NC1(c2ccnc(S(C)(=O)=O)c2)CC1.Cl>>CS(=O)(=O)c1cc(C2(N)CC2)ccn1.Cl,,CO,,C1COCCO1,,val
US06329381B1,CC(C)CN.Nc1nc(Cl)nc2c1ncn2Cc1ccccc1>>CC(C)CNc1nc(N)c2ncn(Cc3ccccc3)c2n1,,CCCCO,,[Na+].[OH-],,val
US20120245178A1,CCOC(=O)c1nc2cnccc2s1>>OCc1nc2cnccc2s1,,CCO,,[BH4-].[Na+],,val
US04970218,Clc1ccncc1.N#CCc1cn(N)c2ccccc12>>N#CCc1cn(Nc2ccncc2)c2ccccc12,,CC(C)O,,Cl,,val
US20160200719A1,COC(=O)c1csc(S(=O)(=O)O)c1.ClP(Cl)(Cl)(Cl)Cl>>COC(=O)c1csc(S(=O)(=O)Cl)c1,,ClCCl,,c1ccncc1,,val
US20130317026A1,Cc1cc(C)c(CNC(=O)c2cc(Br)cc3c2cnn3C2CCCC2)c(=O)[nH]1.ClCCl.OB(O)c1cccc(O)c1>>Cc1cc(C)c(CNC(=O)c2cc(-c3cccc(CO)c3)cc3c2cnn3C2CCCC2)c(=O)[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20070093524A1,CCOC(=O)Cc1ccc(CBr)cc1.Oc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1>>O=C(O)Cc1ccc(COc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060079687A1,COC(OC)c1cc(Oc2cccc(NCC3CCCCC3)c2)ccc1[N+](=O)[O-]>>O=Cc1cc(Oc2cccc(NCC3CCCCC3)c2)ccc1[N+](=O)[O-],,C1CCOC1,,Cl,O,val
US20140371199A1,CC(=O)Cl.N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)N5CCOCC5)c(N)c4)nn23)cc1>>CC(=O)Nc1cc(-c2ccc3ncc(-c4ccc(C#N)cc4)n3n2)ccc1C(=O)N1CCOCC1,,ClCCl,O,O=C([O-])O.[Na+],,val
US05594007,CC(C(=O)c1ccc(O[Si](C(C)C)(C(C)C)C(C)C)cc1)N1CCC(O)(c2ccccc2)CC1>>CC(C(=O)c1ccc(O)cc1)N1CCC(O)(c2ccccc2)CC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20030207868A1,CC(C)CCn1c(Cn2c(=O)n(C(C)C)c3ccccc32)nc2cc(CO)ccc21.CCN(CC)S(F)(F)F>>CC(C)CCn1c(Cn2c(=O)n(C(C)C)c3ccccc32)nc2cc(CF)ccc21,,ClCCl,,,,val
US20150183749A1,Nc1nc(=O)[nH]cc1F.O=S(=O)(Cl)c1ccccc1>>Nc1nc(=O)n(S(=O)(=O)c2ccccc2)cc1F,,O,,CC#N,,val
US20040167123A1,COS(=O)(=O)OC(SC)(SC)SC.O=c1cc(O)ccn1CC1CCC1>>CSC(SC)=C1C(=O)C=CN(CC2CCC2)C1=O,,C1COCCO1,,c1ccncc1,,val
US20040132727A1,COc1cc2nccc(Oc3cc(C)c(NC(=O)COc4c(C)cccc4C)cc3C)c2cc1OC>>COc1cc2nccc(Oc3cc(C)c(NCCOc4c(C)cccc4C)cc3C)c2cc1OC,,C1CCOC1,,Cl,[Na+].[OH-],val
US04386085,CC(C)CCBr.CNc1ccccc1>>CC(C)CCN(C)c1ccccc1,,CCN(CC)CC,,c1ccccc1,,val
US20150322083A1,Cc1ccc(NC(=O)c2cc(Br)sc2Br)c(O)c1>>Cc1ccc2c(c1)Oc1sc(Br)cc1C(=O)N2,,O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US05958954,CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(c2ccccc2)=CC(C)(C)O3)cc1>>CC1(C)C=C(c2ccccc2)c2cc(C#Cc3ccc(C(=O)O)cc3)ccc2O1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20050008968A1,COCC(=O)OC.OCCn1cnc2ccccc21>>COCC(=O)OCCn1cnc2ccccc21,,COCCOCCOC,,C[O-].[Na+],,val
US20120309755A1,CC(C)(C)OC(=O)NCc1cc(F)c(Cl)c(Nc2nc3cc(C(=O)N[C@@H]4CC[C@@H](C(F)(F)F)CC4)c(N4CCC(F)CC4)nc3[nH]2)c1Cl>>NCc1cc(F)c(Cl)c(Nc2nc3cc(C(=O)N[C@@H]4CC[C@@H](C(F)(F)F)CC4)c(N4CCC(F)CC4)nc3[nH]2)c1Cl,,C1COCCO1,,Cl,,val
US20040092507A1,CC(C)(C)OC(=O)N1CCN(c2ccccc2N)CC1.CN(C)C(=O)Cl>>CN(C)C(=O)Nc1ccccc1N1CCN(C(=O)OC(C)(C)C)CC1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US05859007,COC(=O)c1coc2ccccc12>>OCc1coc2ccccc12,,CCCCCC,ClCCl,CC(C)C[AlH]CC(C)C,,val
US20100087471A1,Cc1ccc(N)cc1.O=C(O)Cc1ccc(Cl)nc1>>Cc1ccc(NC(=O)Cc2ccc(Cl)nc2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080312234A1,CCc1nc(C(F)(F)F)ccc1C(=O)N(C)OC>>CCc1nc(C(F)(F)F)ccc1C=O,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05250690,FC(F)(Cl)C(Cl)(Cl)Cl.Nc1ccc(O)cc1>>Nc1ccc(OC(F)(F)C(Cl)(Cl)Cl)cc1,,CS(C)=O,,[H-].[Na+],,val
US20110182812A1,CN(C)/C=C/C(=O)c1cccc([N+](=O)[O-])c1.Nc1nc2ccccc2[nH]1>>O=[N+]([O-])c1cccc(-c2ccn3c(n2)nc2ccccc23)c1,,CC(=O)O,,,,val
US20140243310A1,O=C(CCl)N1CCOCC1.OC1CCc2nc(-c3ccc(OCC4CC4)c(F)c3)oc2C1>>O=C(COC1CCc2nc(-c3ccc(OCC4CC4)c(F)c3)oc2C1)N1CCOCC1,,C1CCOC1,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20140187553A1,CC(C)(C)OC(=O)n1cc(-c2cccc(N3CCOCC3)n2)c2cc(-c3nnc(S(C)(=O)=O)s3)ccc21>>CC(C)(C)OC(=O)n1cc(-c2cccc(N3CCOCC3)n2)c2cc(-c3nncs3)ccc21,,CCO,,CC(=O)O,[BH4-].[Na+],val
US04025637,CCOC(=O)C(C)c1ccc(O)c(N)c1.O=C(Cl)Cc1ccccc1>>CCOC(=O)C(C)c1ccc2oc(Cc3ccccc3)nc2c1,,c1ccncc1,,,,val
US04920120,CC1(C)COC(c2c(F)c(F)c(F)c(F)c2F)=N1.[Li]C>>Cc1c(F)c(F)c(F)c(F)c1C1=NC(C)(C)CO1,,CCOCC,O,,,val
US20090099229A1,COC(=O)C(O)c1cc(Cl)cc(Cl)c1.CS(=O)(=O)Cl>>COC(=O)C(OS(C)(=O)=O)c1cc(Cl)cc(Cl)c1,,ClCCl,,CCN(CC)CC,O,val
US20080167306A1,BrCc1ccc(I)cc1.COC(=O)C(C)(C)O>>COC(=O)C(C)(C)OCc1ccc(I)cc1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],[Cl-].[NH4+],val
US20090264406A1,CC(c1cc2cnn(C)c2cc1F)c1cnc2ccc(Cl)nn12.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>CC(c1cc2cnn(C)c2cc1F)c1cnc2ccc(-c3cnn(C)c3)nn12,,COCCOC,,,,val
US20080045555A1,CCCCCn1c(N)c(N)c(=O)[nH]c1=O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCCCCn1c(=O)[nH]c(=O)c2[nH]c(C(F)(F)F)nc21,,CN(C)C=O,,,,val
US20140228348A1,C=C(/C=C/OC)O[Si](C)(C)C.C=CC#N>>N#CC1=CCC(=O)CC1,,c1ccccc1,,C1CCOC1,Cl,val
US20160206616A1,CC(C[C@H]1CC(F)(F)CN1)C(=O)O.CCOC(=O)C1=C(CBr)NC(c2nccs2)=N[C@H]1c1ccc(Cl)cc1Cl>>CCOC(=O)C1=C(CN2CC(F)(F)C[C@@H]2CC(C)C(=O)O)NC(c2nccs2)=N[C@H]1c1ccc(Cl)cc1Cl,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090099213A1,COCCOC.Clc1ncc2[nH]cnc2n1.N#CCc1ccc(B(O)O)cc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>N#CCc1ccc(-c2ncnc3c2ncn3C2CCCCO2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20150011546A1,CCC(=O)C(C)Br.Cc1[nH]c2ncccc2c1C(=O)OC(C)(C)C>>CCC(=O)C(C)n1c(C)c(C(=O)OC(C)(C)C)c2cccnc21,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080009515A1,CCOC(=O)c1cnc(Cl)c2c(COc3cc(-c4cn(Cc5ccc(Cl)cc5)nn4)ccc3C)csc12.N>>CCOC(=O)c1cnc(N)c2c(COc3cc(-c4cn(Cc5ccc(Cl)cc5)nn4)ccc3C)csc12,,CC(C)O,,,,val
US20160009691A1,COc1ncc(Cc2cnc(O)nc2)cc1-c1cccc(Cl)c1.O=C(O)C(F)(F)S(=O)(=O)F>>COc1ncc(Cc2cnc(OC(F)F)nc2)cc1-c1cccc(Cl)c1,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20100010053A1,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.N#Cc1cc2[nH]cc(C=O)c2cc1F>>CCOC(=O)/C=C/c1c[nH]c2cc(C#N)c(F)cc12,,CC#N,,,,val
US04798833,CCOC(=O)CC(=O)OCC.COC(CBr)OC>>CCOC(=O)C(CC(OC)OC)C(=O)OCC,,CCO,,C,C[O-].[Na+],val
US20120088748A1,CC(C)(C)[Si](C)(C)Cl.OCC1OCCN(Cc2ccccc2)CC1c1ccc(Cl)c(Cl)c1>>CC(C)(C)[Si](C)(C)OCC1OCCN(Cc2ccccc2)CC1c1ccc(Cl)c(Cl)c1,CN(C)c1ccncc1,CN(C)C=O,,CCN(CC)CC,O,val
US20080188463A1,CCCC(O)(C(=O)N[C@@H]1C(=O)Nc2ccccc2-c2ccccc21)C(=O)OCC>>CCCC(O)(C(=O)O)C(=O)N[C@@H]1C(=O)Nc2ccccc2-c2ccccc21,,C1CCOC1,O,[Li+].[OH-],,val
US20090286811A1,COCCOc1c(C=O)cccc1OC.Cc1nc2sc3ccccc3n2c(=O)c1-c1ccc(C(F)(F)F)cc1>>COCCOc1c(/C=C/c2nc3sc4ccccc4n3c(=O)c2-c2ccc(C(F)(F)F)cc2)cccc1OC,,CCO,,C,C[O-].[Na+],val
US20050277681A1,CC[Mg]Br.O=C(O)C(=O)c1ccccc1>>CCC(O)(C(=O)O)c1ccccc1,,C1CCOC1,,,,val
US04429155,CCC1CCCC(CC)C1N>>CCc1cccc(CC)c1N,[Pd],,,,,val
US04308391,CCOC(=O)CC(=O)c1ccc(Cl)cc1Cl.NC(N)=S>>CCOC(=O)c1sc(N)nc1-c1ccc(Cl)cc1,,CCO,,,,val
US20100216746A1,CC(C)(C)OC(=O)Nc1cccc2cc(C(=O)NCc3ccc(Cl)c(Oc4cc(Cl)cc(C#N)c4)c3F)[nH]c12>>N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CNC(=O)c3cc4cccc(N)c4[nH]3)c2F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110144179A1,O=C(O)c1ccccc1-c1cccs1.O=C(OCc1ccccc1)N1C[C@@H](NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)[C@H](O)C1>>O=C(S[C@H]1CN(C(=O)OCc2ccccc2)C[C@H]1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1)c1ccccc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080045521A1,COC(=O)[C@H](Cc1ccc(OCCc2ccc3c(n2)NCCC3)cn1)NC(=O)OC(C)(C)C>>COC(=O)[C@@H](N)Cc1ccc(OCCc2ccc3c(n2)NCCC3)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05326776,CCOC(=O)c1c(N)nc(SC)n1C>>CCOC(=O)c1c(N)ncn1C,[Ni],CCO,,,,val
US20030069273A1,CN1CCNCC1.O=C(O)c1ccc(-n2nc(-c3ccccc3O)nc2-c2ccccc2O)cc1>>CN1CCN(C(=O)c2ccc(-n3nc(-c4ccccc4O)nc3-c3ccccc3O)cc2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20160083370A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCCCCc1c[nH]c2ccccc12>>Cc1ccc(S(=O)(=O)OCCCCc2c[nH]c3ccccc23)cc1,,ClCCl,,,,val
US20130102576A1,COCCN(CCN(c1ccc2c(c1)C(=O)N(CC(=O)OCc1ccccc1)C2=O)S(C)(=O)=O)C(=O)OC(C)(C)C>>COCCN(CCN(c1ccc2c(c1)C(=O)N(CC(=O)O)C2=O)S(C)(=O)=O)C(=O)OC(C)(C)C,[Pd],CO,,,,val
US20060258672A1,COC(=O)C1CNC1.Clc1ncccn1>>COC(=O)C1CN(c2ncccn2)C1,,CO,,Cl,,val
US20130065897A1,CCCCI.O=C1NCc2cc(-c3ccc(C4OCCO4)s3)ccc21>>CCCCN1Cc2cc(-c3ccc(C4OCCO4)s3)ccc2C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20060148858A1,CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCC(=O)OCC>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO,,C1CCOC1,CCCCCC,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US05252538,CCOC(=O)c1cc([N+](=O)[O-])c(=O)[nH]c1C(=O)OCC.O=P(Cl)(Cl)Cl>>CCOC(=O)c1cc([N+](=O)[O-])c(Cl)nc1C(=O)OCC,,CCOC(C)=O,,,,val
US20120329704A1,COC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cnccn1)C1CCCCC1)C(C)(C)C>>CC(C)(C)[C@H](NC(=O)[C@@H](NC(=O)c1cnccn1)C1CCCCC1)C(=O)O,,C1CCOC1,,CO,[Na+].[OH-],val
US20060004052A1,O=C(O)CCC(=O)Nc1cc2c3c(c(-c4ccccc4)[nH]c3c1)C=NNC2=O>>O=C1NN=Cc2c(-c3ccccc3)[nH]c3cc(N4C(=O)CCC4=O)cc1c23,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160145247A1,C=Cc1ccc(N)c(CC(=O)OC(C)(C)C)c1>>CCc1ccc(N)c(CC(=O)OC(C)(C)C)c1,,CCOC(C)=O,,,,val
US04289763,CC(C)(C)C(=O)OC(=O)C(C)(C)C.C[C@@H]1C[C@H]2[C@@H]3C[C@H](Cl)C4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO>>C[C@@H]1C[C@H]2[C@@H]3C[C@H](Cl)C4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@H]1C(=O)COC(=O)C(C)(C)C,,ClCCCl,ClCCl,O,[Na+].[OH-],val
US20050143422A1,CC(C)[C@@H](N)C(=O)O.O=[N+]([O-])c1ccc(-c2ccc(S(=O)(=O)Cl)cc2)cc1>>CC(C)[C@@H](NS(=O)(=O)c1ccc(-c2ccc([N+](=O)[O-])cc2)cc1)C(=O)O,,C1COCCO1,O,CCN(CC)CC,,val
US04892870,CCN1OCCC(C(O)c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)C1=O>>CCN1OCCC(=Cc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)C1=O,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140371203A1,ClCCN1CCCC1.OCC1CCN(c2ncnc3scc(-c4ccccc4)c23)CC1>>c1ccc(-c2csc3ncnc(N4CCC(COCCN5CCCC5)CC4)c23)cc1,,CN(C)C=O,CO,Cl,[H-].[Na+],val
US20060106096A1,Cl.N#Cc1cccc(N=C=O)c1.Nc1ccc2cc(C(=O)N[C@H]3CN4CCC3CC4)sc2c1>>Cl.N#Cc1cccc(NC(=O)Nc2ccc3cc(C(=O)N[C@H]4CN5CCC4CC5)sc3c2)c1,,C1CCOC1,,CCN(CC)CC,Cl,val
US05703089,NCCNCCCNCCN.O=C1OC(=O)c2c3ccccc3cc3cccc1c23>>NCCNCCCNCCN1C(=O)c2cccc3cc4ccccc4c(c23)C1=O,,CCO,,,,val
US20100249149A1,COc1ccc(F)cc1-c1cc(NC(=O)C2CCN(C(=O)OCc3ccccc3)CC2)ncn1>>COc1ccc(F)cc1-c1cc(NC(=O)C2CCNCC2)ncn1,[Pd],CO,,,,val
US20080021069A1,COc1ccc(-n2c(SCc3ccc(Br)cc3)nc3cc(Br)ccc32)cc1.Cl>>COc1ccc(-n2c(SCc3ccc(Br)cc3)nc3cc(Br)ccc32)cc1.Cl,,CCOCC,,CCOC(C)=O,,val
US05290801,CCCCCCCN(CCCCCBr)C(=O)Nc1ccc(F)cc1F.O=[N+]([O-])c1ccc2c(c1)=NC(=S)N=2>>CCCCCCCN(CCCCCSc1nc2ccc([N+](=O)[O-])cc2[nH]1)C(=O)Nc1ccc(F)cc1F,,CN(C)C=O,O,[H-].[Na+],,val
US04910319,CC1=CC(=O)N(Cc2ccccc2)C1=O.NCc1ccccc1>>CC1(NCc2ccccc2)CC(=O)N(Cc2ccccc2)C1=O,,C1CCOC1,,,,val
US20120289522A1,CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1C=CC(C)Cc1ccc(C(C)C)cc1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4C=CC(C)Cc4ccc(C(C)C)cc4)cc3)cc2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,,,val
US20120244110A1,CC(C)(C)OC(=O)N1CCc2nc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)ccc2C1>>c1cc2c3cnc(Nc4ccc5c(n4)CCNC5)nc3n(C3CCCC3)c2cn1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20040235822A1,Cc1ccc2ncc(CO)n2c1.O=[N+]([O-])c1ccc(S)cc1>>Cc1ccc2ncc(CSc3ccc([N+](=O)[O-])cc3)n2c1,,CC(=O)O,,Cl,[Na+].[OH-],val
US20090093497A1,CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3nc(-c4ccccc4)oc3C(F)(F)F)cc2)CC1.Cl>>Cl.O=C(Nc1ccc(N2CCNCC2)cc1)c1nc(-c2ccccc2)oc1C(F)(F)F,,C1COCCO1,,,,val
US20050009907A1,COc1ccc(-c2ccc(C=O)c3ccccc23)cc1F>>O=Cc1ccc(-c2ccc(O)c(F)c2)c2ccccc12,,O,,Cl,c1ccncc1,val
US20110034464A1,CON.CSc1ccc(Br)cc1C=O>>CON=Cc1cc(Br)ccc1SC,,c1ccncc1,,Cl,O,val
US20050245563A1,CN(C)CCCCl.Cc1nn(C2CCCCO2)c2c1c(=O)[nH]c1ccc(Cl)cc12>>Cc1nn(C2CCCCO2)c2c1c(=O)n(CCCN(C)C)c1ccc(Cl)cc21,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US05104888,CC(=O)Oc1cc2c(cc1C(C)(C)C)OC(C)(COc1ccc([N+](=O)[O-])cc1)CC2=O>>CC1(COc2ccc([N+](=O)[O-])cc2)CC(O)c2cc(O)c(C(C)(C)C)cc2O1,,C1CCOC1,CO,Cl,[BH4-].[Na+],val
US04370326,CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CCS[C@H]12)c1csc(N)n1.O=CO>>Nc1nc(C(N)C(=O)NC2C(=O)N3C(C(=O)O)=CCS[C@H]23)cs1.O=CO,[Zn],O=CO,,,,val
US20080146606A1,NC1CCS(=O)(=O)C1.O=S(=O)(Cl)c1ccc(Br)cc1>>O=S1(=O)CCC(NS(=O)(=O)c2ccc(Br)cc2)C1,,ClCCl,,,,val
US20110034507A1,COC(=O)c1cccc(N2Cc3ccc(OC)cc3CC2=O)c1>>COC(=O)c1cccc(N2Cc3ccc(O)cc3CC2=O)c1,,ClCCl,,BrB(Br)Br,,val
US20140179666A1,C[C@@H]1COCCN1C[C@H]1CN(C(=O)OC(C)(C)C)[C@H](C)CN1CC(=O)N1CC(C)(C)c2ncc(Cc3ccc(F)cc3)cc21>>C[C@@H]1COCCN1C[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ncc(Cc3ccc(F)cc3)cc21,,C1COCCO1,CCOC(C)=O,Cl,,val
US20060019985A1,CC(C)(C)OC(=O)N1CCC(c2cccnc2)C1>>CC(C)(C)OC(=O)N1CCC(C2CCCNC2)C1,O=[Pt]=O,CC(=O)O,CO,,,val
US20020022631A1,CCOC(=O)C(NC(C)=O)C(=O)OCC.ClCc1cncs1>>CCOC(=O)C(Cc1cncs1)(NC(C)=O)C(=O)OCC,,CCO,,[Na],,val
US20090233929A1,CCOC(=O)c1cn(-c2cccc(-c3cccnc3Cl)c2)cn1>>O=C(O)c1cn(-c2cccc(-c3cccnc3Cl)c2)cn1,,CCO,,[K+].[OH-],,val
US06362177B1,FC(F)(F)Sc1ccc(CBr)cc1.Nc1ccc(Cl)cc1C(=O)NCC(=O)NCC1CCNCC1>>Nc1ccc(Cl)cc1C(=O)NCC(=O)NCC1CCN(Cc2ccc(SC(F)(F)F)cc2)CC1,,ClC(Cl)Cl,,CC#N,,val
US20030158219A1,CCOC(=O)C(=Cc1cccc(OC)c1[N+](=O)[O-])C(=O)OCC>>CCOC(=O)c1cc2cccc(OC)c2[nH]c1=O,[Fe],CC(=O)O,,,,val
US20100197681A1,CCCCO.CCN(C(C)C)C(C)C.COc1cccc(C(=O)Nc2nc3cccc(Br)n3n2)c1>>COc1cccc(C(=O)Nc2nc3cccc(NC4CCC(O)CC4)n3n2)c1,,CCCCO,,,,val
US20080269219A1,CCCc1ncc[nH]1.COc1ccccc1OCCCc1oc(Cl)nc1-c1ccc(Cl)cc1>>CCCc1nccn1-c1nc(-c2ccc(Cl)cc2)c(CCCOc2ccccc2OC)o1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160184318A1,COC(=O)c1ccc(Cl)cc1Cn1nnc(C)n1>>Cc1nnn(Cc2cc(Cl)ccc2C(=O)O)n1,,CO,,[Na+].[OH-],,val
US04209625,CN1CCC2(CC1)CNc1cc(Cl)ccc12.Fc1ccccc1Cl.O=C(O)/C=C\C(=O)O>>CN1CCC2(CC1)CN(c1ccccc1Cl)c1cc(Cl)ccc12.O=C(O)/C=C\C(=O)O,,CCOCC,CS(C)=O,[H-].[Na+],,val
US20070213325A1,CSc1nccc(-c2cccnc2Oc2ccc(N)cc2)n1.S=C(Oc1ccccn1)Oc1ccccn1>>CSc1nccc(-c2cccnc2Oc2ccc(N=C=S)cc2)n1,,ClCCl,,,,val
US20130158004A1,CNC.ClCCl.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(n1ccnc1)n1ccnc1>>C[C@H](NC(=O)N(C)C)c1ccc(O)cc1,,ClCCl,,,,val
US20070185092A1,C=O.O=C(NCc1cn(-c2ccc(N3CCNCC3=O)cc2)nn1)c1ccc(Cl)s1>>CN1CCN(c2ccc(-n3cc(CNC(=O)c4ccc(Cl)s4)nn3)cc2)C(=O)C1,,CC(=O)O,,[BH3-]C#N.[Na+],,val
US04929741,C#CCOC(C)OCC.O=Cc1ccc(F)cc1>>CCOC(C)OCC#CC(O)c1ccc(F)cc1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20070043013A1,C[C@H](CCO)NC(=O)OC(C)(C)C.II>>C[C@H](CCI)NC(=O)OC(C)(C)C,,ClCCl,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030158413A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccc2c(c1)SCC[C@@H]2N>>COC(=O)c1ccc2c(c1)SCC[C@@H]2NC(=O)OC(C)(C)C,,O,,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US20130131018A1,CCOC(CN)OCC.CCOc1cccc(C=O)c1>>CCOc1cccc(/C=N/CC(OCC)OCC)c1,,Cc1ccccc1,,O,,val
US05684003,CC(C)O.O=C(O)Cc1cc(OCc2ccccc2)ccc1[N+](=O)[O-]>>CC(C)OC(=O)Cc1cc(OCc2ccccc2)ccc1[N+](=O)[O-],CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20100261902A1,CCC(O)I.O=c1[nH]cccc1OCc1ccccc1>>O=c1c(OCc2ccccc2)cccn1CCCO,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040092598A1,ClCCl.O=C(O)C=Cc1ccc2c(c1)OCO2>>O=C(Cl)C=Cc1ccc2c(c1)OCO2,CN(C)C=O,,,,,val
US20070213314A1,FC(F)(F)c1cc(CNCc2cc(C(F)(F)F)ccc2Br)cc(C(F)(F)F)c1.N#CBr>>N#CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cc(C(F)(F)F)ccc1Br,,CCO,,O,CC(=O)[O-].[Na+],val
US20130172556A1,CC(=O)CS(C)(=O)=O.NN>>CC(CS(C)(=O)=O)=NN,,CCO,,O,,val
US04374262,CC(=O)OC(C)=O.Oc1ccc2cc(Br)ccc2c1>>CC(=O)Oc1ccc2cc(Br)ccc2c1,,Cc1ccccc1,,CC(=O)[O-].[Na+],,val
US20040110945A1,CCOC(=O)Cc1cc(Cl)c(NC(=O)c2n[nH]c3ccccc23)cc1F>>O=C(O)Cc1cc(Cl)c(NC(=O)c2n[nH]c3ccccc23)cc1F,,CO,Cl,[Na+].[OH-],,val
US20080312183A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.O=c1ccn(CCC(CO)CO)c(=O)[nH]1>>O=c1ccn(CCC(CO)COC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]1,CN(C)c1ccncc1,CN(C)C=O,O,CCN(CC)CC,,val
US20110178132A1,N#Cc1cc(Cl)ccn1.OB(O)c1cc(C(F)(F)F)ccc1F>>N#Cc1cc(-c2cc(C(F)(F)F)ccc2F)ccn1,,C1COCCO1,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20150376233A1,C=CCCC(C)C[C@@H](COC)C(N=C(c1ccccc1)c1ccccc1)C(=O)OCC>>C=CCCC(C)C[C@@H](COC)C(N)C(=O)OCC,,CCOCC,,Cl,,val
US20090221583A1,O=C(NCC(=O)N1CCNCC1)c1ccc(-c2ccccc2)cc1.O=C1OC(=O)c2ccccc21>>O=C(NCC(=O)N1CCN(C(=O)c2ccccc2C(=O)O)CC1)c1ccc(-c2ccccc2)cc1,,Cc1ccccc1,,,,val
US20080058349A1,NC1=NC(c2cccc(Br)c2)(c2cccc(OS(=O)(=O)C(F)(F)F)c2)C2=NCCCN12.OB(O)c1cccc(Cl)c1>>NC1=NC(c2cccc(OS(=O)(=O)C(F)(F)F)c2)(c2cccc(-c3cccc(Cl)c3)c2)C2=NCCCN12,,C1COCCO1,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20030186926A1,CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(C#CCC4CCC(C(=O)OC)CC4)nc32)[C@H](O)[C@@H]1O.CN>>CCNC(=O)C1OC(n2cnc3c(N)nc(C#CCC4CCC(C(=O)NC)CC4)nc32)C(O)C1O,,CO,,,,val
US04477466,CN(C)CC(C)(C)C(=O)Cl.NS(=O)(=O)c1ccc(S(=O)(=O)c2ccc(O)cc2)s1>>CN(C)CC(C)(C)C(=O)Oc1ccc(S(=O)(=O)c2ccc(S(N)(=O)=O)s2)cc1,,CC(C)=O,,CCN(CC)CC,Cl,val
US20140088085A1,COc1cc(C=O)ccc1OCc1ccccc1.O=[N+]([O-])O>>COc1cc(C=O)c([N+](=O)[O-])cc1OCc1ccccc1,,ClCCCl,,O,,val
US20020137739A1,C=O.CCOC(=O)Cl.CCOC(=O)c1nn[nH]c1C(=O)c1cc(OC)c(OC)cc1[N+](=O)[O-]>>CCOC(=O)OCn1nc(C(=O)OCC)c(C(=O)c2cc(OC)c(OC)cc2[N+](=O)[O-])n1,,ClCCl,c1ccncc1,Cc1ccc(S(=O)(=O)O)cc1,O,val
US05747516,CN(C)N.Cc1ccccc1N=C=O>>Cc1ccccc1NC(=O)NN(C)C,,Cc1ccccc1,,,,val
US20130317026A1,CC(Br)c1ccccc1.Cc1cc(C)c(CNC(=O)c2cc(Br)nc3[nH]ncc23)c(=O)[nH]1>>Cc1cc(C)c(CNC(=O)c2cc(Br)nc3c2cnn3C(C)c2ccccc2)c(=O)[nH]1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04433152,Cl.N=C(N)N1CCC(C(=O)O)CC1.O=C(OCc1ccccc1)c1ccccc1OS(=O)Oc1ccccc1C(=O)OCc1ccccc1>>Cl.N=C(N)N1CCC(C(=O)Oc2ccccc2C(=O)OCc2ccccc2)CC1,,c1ccncc1,,CN(C)C=O,,val
US20060264460A1,N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(Cl)c1.O=Cc1ccco1>>N#Cc1cnc2ccc(NCc3ccco3)cc2c1Nc1ccc(F)c(Cl)c1,,CCO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20140275085A1,COc1nc(N2CCCC2)ncc1-c1cc(C)c(Oc2ccnc(-c3cnn(C)c3)c2)cn1>>Cc1cc(-c2cnc(N3CCCC3)[nH]c2=O)ncc1Oc1ccnc(-c2cnn(C)c2)c1,,CC(=O)O,,Br,,val
US20160046612A1,CI.COC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]cnc12>>COC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2c1ncn2C,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20130165464A1,CC(=O)Nc1cc(B2OC(C)(C)C(C)(C)O2)c(C)cn1.CCOC(=O)c1c[nH]nc1I>>CCOC(=O)c1cn(-c2cc(NC(C)=O)ncc2C)nc1I,,C1CCOC1,,c1ccncc1,,val
US06420507B1,CC1=C(C)C(N(C2CCCCC2)[SiH](C)C)c2cc(C)cc(C)c21.CC1=C(c2ccccc2)c2cc3c(cc2C1[Si](C)(C)Cl)CCC3>>CC1=C(c2ccccc2)c2cc3c(cc2C1[Si](C)(C)NC1CCCCC1)CCC3,,CCCCCC,,CCN(CC)CC,,val
US20110059954A1,CCI.Cc1cc(C(=O)c2cc(Cl)ncn2)cc2oc(=O)[nH]c12>>CCn1c(=O)oc2cc(C(=O)c3cc(Cl)ncn3)cc(C)c21,,CN(C)C=O,,[H-].[Na+],,val
US20080085890A1,O=[N+]([O-])O.c1ccc(-c2c[nH]cn2)cc1>>O=[N+]([O-])c1ccc(-c2c[nH]cn2)cc1,,O=S(=O)(O)O,,[Na+].[OH-],,val
US20160272621A1,CC(=O)CCCCl.CC(C)(C)OC(=O)Nc1ccc(Cl)nc1>>CC(C)(C)OC(=O)Nc1cnc(Cl)cc1C1(C)CCCO1,,CCOCC,,CN(C)CCN(C)C,[Li]CCCC,val
US20160039841A1,COC(=O)CCn1c(=O)c2c(C)c(-c3ccc(Cl)cc3)sc2n(C)c1=O.O=C1CCC(=O)N1Br>>COC(=O)CCn1c(=O)c2c(CBr)c(-c3ccc(Cl)cc3)sc2n(C)c1=O,,ClC(Cl)(Cl)Cl,ClCCl,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20090258851A1,NCc1ccco1.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1Cc1ccco1,,CCO,,,,val
US20150011508A1,Cc1ccc(/C(N)=N/O)cc1[N+](=O)[O-].O=C(O)COCC(F)(F)F>>Cc1ccc(-c2noc(COCC(F)(F)F)n2)cc1[N+](=O)[O-],,CN1CCCC1=O,,O=C(n1ccnc1)n1ccnc1,,val
US20100105642A1,COC(C=O)OC.C[C@@H](N)C(C)(C)C>>COC(CN[C@H](C)C(C)(C)C)OC,[Pd],CO,,,,val
US20150336905A1,CS(C)=O.O=C(c1ccc(Br)cc1Cl)C1CC1>>Clc1cc(Br)ccc1C1(C2CC2)CO1,,CS(C)=O,,O,CC(C)(C)[O-].[K+],val
US20030212054A1,CNCc1nccn1-c1ccc2c(c1)CCN2C(=O)OC(C)(C)C.CS(=O)(=O)Cl>>CN(Cc1nccn1-c1ccc2c(c1)CCN2C(=O)OC(C)(C)C)S(C)(=O)=O,,ClCCl,,CCN(CC)CC,Cl,val
US20130029948A1,COC(=O)c1cncc(Sc2c(C)[nH]c3cc(Cl)ccc23)c1.Cn1cc(Br)cn1>>COC(=O)c1cncc(Sc2c(C)n(-c3cnn(C)c3)c3cc(Cl)ccc23)c1,O=[Cu],CCOC(C)=O,c1ccncc1,O=C([O-])[O-].[K+].[K+],,val
US20150225378A1,Cc1ncnc(O)c1Cl.O=P(Cl)(Cl)Cl>>Cc1ncnc(Cl)c1Cl,,Cc1ccccc1,,,,val
US05858995,CCOC(=O)CC(C)=O.Cc1oc2c([N+](=O)[O-])cccc2c1CCl>>CCOC(=O)C(Cc1c(C)oc2c([N+](=O)[O-])cccc12)C(C)=O,,CCO,O,Cl,[Na],val
US20100228026A1,CC(C)Nc1cccnc1.CCN(C(=O)C(Cc1ccc(Cl)cc1)C(=O)NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1.Cl>>CC(C)N(C(=O)C(Cc1ccc(Cl)cc1)C(=O)NS(=O)(=O)c1ccc2ccccc2c1)c1cccnc1.Cl,,CCO,,,,val
US20040077655A1,O=C(OCC1c2ccccc2-c2ccccc21)N1CCN(CCc2nc3c(F)cccc3[nH]2)CC1>>Fc1cccc2[nH]c(CCN3CCNCC3)nc12,,CC#N,,C1CCNCC1,,val
US05451688,C[C@H]1C=CC2=C[C@@H](O)C[C@H](O)[C@@H]2[C@H]1CC[C@@H](O)C[C@@H](O)CC(=O)O>>C[C@H]1C=CC2=C[C@@H](O)C[C@H](O)[C@@H]2[C@H]1CC[C@@H]1C[C@@H](O)CC(=O)O1,,C1CCOC1,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20070004753A1,CC(C)(C)OC(=O)N1CCN(c2ccc(N)cc2)CC1.C[Si](C)(C)C#N.O=C1CCC1>>CC(C)(C)OC(=O)N1CCN(c2ccc(NC3(C#N)CCC3)cc2)CC1,,CC(C)=O,ClCCl,O=S(=O)([O-])[O-].[Na+].[Na+],,val
US06403601B1,COC(=O)c1cc(O)cc2c1CCCC2.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1cc(OS(=O)(=O)C(F)(F)F)cc2c1CCCC2,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20060217387A1,CCO.NC(=O)c1nc[nH]c1N>>CCOC(=O)c1nc[nH]c1N,,CS(=O)(=O)O,,,,val
US20160159752A1,CC(C)(C)OC(=O)N1C[C@H](CO)N(Cc2ccccc2)C2(CC2)C1>>CC(C)(C)OC(=O)N1C[C@H](CO)NC2(CC2)C1,[Pd],CCO,ClCCl,,,val
US20100166887A1,Nc1ccccc1C(=O)O.O=[N+]([O-])c1cc(Cl)ccc1Cl>>O=C(O)c1ccccc1Nc1ccc(Cl)cc1[N+](=O)[O-],I[Cu]I,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110269987A1,CCCCCC.CCCCCCCCCCCCCCCCO.NC(=O)CCCCC1CCSS1>>CCC/C=C\CCCCCCCCC(=O)OCCCCCCCCCCCCCCCC,,CCCCCC,,,,val
US20120172367A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1ccc(F)cc1OCc1ccccc1>>CC(C)(C)OC(=O)NCc1ccc(F)cc1OCc1ccccc1,,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20090131458A1,CC(C)COc1nc(N)c2nc(Br)n(CC3CCOCC3)c2n1.[OH-]>>CC(C)COc1nc(N)c2[nH]c(=O)n(CC3CCOCC3)c2n1,,CCCCO,,Cl,,val
US20080058309A1,C[Si](C)(C)CCOCn1ccc(-c2ccc3c(NC(=O)CCl)c(Cl)ccc3n2)n1.Nc1ccc(F)cc1>>C[Si](C)(C)CCOCn1ccc(-c2ccc3c(NC(=O)CNc4ccc(F)cc4)c(Cl)ccc3n2)n1,,CC#N,,CCN(CC)CC,,val
US20100311966A1,CN(C)C(OC(C)(C)C)OC(C)(C)C.CO[C@@H]1CN(c2cccc(C(=O)O)c2)CC[C@@H]1NC(=O)OCc1ccccc1>>CO[C@@H]1CN(c2cccc(C(=O)OC(C)(C)C)c2)CC[C@@H]1NC(=O)OCc1ccccc1,,C1CCOC1,Cc1ccccc1,CCOC(C)=O,,val
US20080090839A1,C#CCBr.COC(=O)CC(C)N1CCN(c2ccc(O)cc2)CC1>>C#CCOc1ccc(N2CCN(CCC(=O)OC)CC2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140163012A1,Brc1ccc2sc3c(c2c1)CCNCC3.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCc2sc3ccc(Br)cc3c2CC1,,CO,,CCN(CC)CC,,val
US20090291965A1,COc1ccccc1C(=O)NNC(=O)Cc1ccc(C(=O)OC(C)(C)C)cc1>>COc1ccccc1-c1nnc(Cc2ccc(C(=O)O)cc2)o1,,C1CCOC1,,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US20100093698A1,COc1cc(C(=O)N(C)OC)ccn1.COc1cc(C(=O)c2cccc3nc(Nc4ccc(C(F)(F)F)cc4)nn23)ccn1>>CC(c1cc[nH]c(=O)c1)c1cccc2nc(Nc3ccc(C(F)(F)F)cc3)nn12,,C1CCOC1,,[Li]CCCC,,val
US20060004017A1,COc1cc2c(Cl)ncnc2cc1OCCCN1CCOCC1.Oc1cc2cc[nH]c2cc1F>>COc1cc2c(Oc3cc4cc[nH]c4cc3F)ncnc2cc1OCCCN1CCOCC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100105651A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1CN(C(c2ccccc2)c2ccccc2)C1N>>CC1(NC(=O)OC(C)(C)C)CN(C(c2ccccc2)c2ccccc2)C1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20020120007A1,COc1ccc(C(=O)Nc2ccccc2N)cc1.O=C(O)CCCC(=O)N1CCOCC1>>COc1ccc(C(=O)Nc2ccccc2NC(=O)CCCC(=O)N2CCOCC2)cc1,,ClCCl,,,,val
US05409943,CCOC(=N)Cc1ccc(OC)cc1.Cl.Nc1ncccc1OCc1ccc(F)cc1>>COc1ccc(CC(=N)Nc2ncccc2OCc2ccc(F)cc2)cc1.Cl,,CCO,,,,val
US06306852B1,CCOC(=O)/C=C/c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)cn(C)c2c1>>CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(/C=C/C(=O)O)ccc23)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20070112016A1,CC(=O)OCCN1C(=O)C2(CCNCC2)c2cc(CC3CCCCCCC3)ccc21>>O=C1N(CCO)c2ccc(CC3CCCCCCC3)cc2C12CCNCC2,,CO,,C[O-].[Na+],,val
US20020077345A1,CCOC(=O)C1([C@H]2CN([C@@H](C)c3ccccc3)C(=O)[C@H]2F)CC1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)C1([C@H]2CN([C@@H](C)c3ccccc3)C(=S)[C@H]2F)CC1,,Cc1ccccc1,,,,val
US20050148623A1,CI.COC(=O)Cl.N[C@@H](CS)C(=O)O>>COC(=O)N[C@@H](CSC)C(=O)O,,CO,,Cl,[Na+].[OH-],val
US20030166639A1,Cc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccnc(C(F)(F)F)c3)c2)cc1Cl>>Cc1cc2c(cc1Cl)NC(=O)CC(c1cccc(-c3ccnc(C(F)(F)F)c3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090197871A1,CC1CNCC(C)N1.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2cc(-c3cccc(C=O)c3)ccc2C)c1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2cc(-c3cccc(CN4C[C@H](C)N[C@H](C)C4)c3)ccc2C)c1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US03944675,Nc1ccccc1.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>O=C(Nc1ccccc1)C12CC3CC(CC(C3)C1)C2,,CCOC(C)=O,,CCOCC,O,val
US20030045527A1,ClCCN(CCCl)Cc1ccccc1.Nc1cccc2[nH]ccc12>>c1ccc(CN2CCN(c3cccc4[nH]ccc34)CC2)cc1,,Clc1ccccc1,,CCN(C(C)C)C(C)C,Cl,val
US20160108039A1,CCC(C(=O)OC)N(CC1CCN1)C(=O)OCc1ccccc1>>CCC1C(=O)N2CCC2CN1C(=O)OCc1ccccc1,,CO,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20120077793A1,CC(C)(C)OC(=O)NC(C(=O)N1CC[C@H](F)C1)c1ccc(O)cc1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)NC(C(=O)N1CC[C@H](F)C1)c1ccc(OS(=O)(=O)C(F)(F)F)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20160221946A1,CN(Cc1cn(S(=O)(=O)c2cccnc2)c2cc(B3OC(C)(C)C(C)(C)O3)ccc12)C(=O)OC(C)(C)C.OO>>CN(Cc1cn(S(=O)(=O)c2cccnc2)c2cc(O)ccc12)C(=O)OC(C)(C)C,,COCCOC,,[Na+].[OH-],,val
US20110034689A1,Cc1nc2cc(Oc3ccc([N+](=O)[O-])cc3C)ccc2o1>>Cc1nc2cc(Oc3ccc(N)cc3C)ccc2o1,[Pd],CCO,,[H][H],,val
US20040180901A1,NO.O=S(=O)(C=CCCCc1ncccn1)N1CCN(c2ccc(-c3ccccn3)cn2)CC1>>O=S(=O)(CC(CCCc1ncccn1)NO)N1CCN(c2ccc(-c3ccccn3)cn2)CC1,,C1CCOC1,,,,val
US20090012075A1,CCOC(=O)c1cc2ccc(C(=O)O)cc2s1.CN(C)C=O.O>>CCOC(=O)c1cc2ccc(C(=O)N(C)OC)cc2s1,,CN(C)C=O,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US20150087825A1,CC(N)(c1cc(Br)ccc1F)C(F)(F)C1(O)CCOCC1.N#CBr>>CC1(c2cc(Br)ccc2F)N=C(N)OC2(CCOCC2)C1(F)F,,CCO,CCOC(C)=O,,,val
US03950393,CNC.COc1ccc(N)c(CO)c1>>COc1ccc(N)c(CN(C)C)c1,,ClCCl,,O=S(Cl)Cl,,val
US20090264431A1,COc1ccc(Cl)cc1S(=O)(=O)N[C@@H]1C[C@H](CN2C(=O)c3ccccc3C2=O)N(C(=O)OC(C)(C)C)C1>>COc1ccc(Cl)cc1S(=O)(=O)N[C@@H]1C[C@H](CN)N(C(=O)OC(C)(C)C)C1,,CCO,,NN,O,val
US20140323464A1,COc1cc(Nc2nc(NCC3CN(C(=O)CC#N)C3)n3ccnc3c2C(N)=O)cc(OC)c1.O=CC1CC1>>COc1cc(Nc2nc(NCC3CN(C(=O)C(C#N)=CC4CC4)C3)n3ccnc3c2C(N)=O)cc(OC)c1,,C1CCOC1,,C1CCNCC1,,val
US20080262020A1,CO.Cn1c(=O)c(-c2ccc(F)cc2Cl)cc2c3ccccc3n(C)c21>>COc1ccc(-c2cc3c4ccccc4n(C)c3n(C)c2=O)c(Cl)c1,,O,,CN(C)C=O,[H-].[Na+],val
US20160235716A1,C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)CN=[N+]=[N-]>>C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)CN,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130023523A1,CCOC(=O)c1cnc(SC)nc1C(=O)c1cccc(C(OC)OC)c1>>CCOC(=O)c1cnc(SC)nc1C(=O)c1cccc(C=O)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090156642A1,CCO.CCOC(C)=O.CN(Cc1cc(S(=O)(=O)c2cccc(C#N)c2)n(-c2cc(F)ccc2F)n1)C(=O)OC(C)(C)C>>CNCc1cc(S(=O)(=O)c2cccc(C#N)c2)n(-c2cc(F)ccc2F)n1.O=C(O)CCC(=O)O,,CCO,,CCOC(C)=O,Cl,val
US05684022,CCN=C=O.OCCOc1ccc(Cn2cccn2)cc1>>CCNC(=O)OCCOc1ccc(Cn2cccn2)cc1,,Cc1ccccc1,,CCN(CC)CC,,val
US05298503,CNCC1CCN(Cc2ccccc2)CC1.O=C(CCCI)c1ccc(F)cc1>>CN(CCCC(=O)c1ccc(F)cc1)CC1CCN(Cc2ccccc2)CC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130172559A1,O=C(NCc1ccc(F)cc1F)c1cn2c(c(OCc3ccccc3)c1=O)C(=O)N1CC[C@@H]3CCCN3[C@@H]1C2>>O=C(NCc1ccc(F)cc1F)c1cn2c(c(O)c1=O)C(=O)N1CC[C@@H]3CCCN3[C@@H]1C2,[Pd],CO,,,,val
US06498165B1,CCOC=C(C#N)C(=O)OCC.CCSC(=N)N>>CCSc1ncc(C#N)c(O)n1,,CO,,[K+].[OH-],,val
US20160254098A1,CCCC(=O)[O-].CCCC[n+]1cccc(C)c1>>CCCC(=O)[O-].CCCC[n+]1cccc(C)c1,,O,,[Cl-].[Na+],,val
US20040186126A1,CI.O=C(c1cc2nccc(Cl)c2s1)N1CC[C@@H](O)C1>>CO[C@@H]1CCN(C(=O)c2cc3nccc(Cl)c3s2)C1,,C1CCOC1,,[H-].[Na+],,val
US20060083681A1,COc1nc(CCCCCCCCCOC2CCCCO2)c(C)c(OCc2ccccc2)c1OC>>COc1nc(CCCCCCCCCO)c(C)c(OCc2ccccc2)c1OC,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070060629A1,Cc1onc(-c2ccccc2)c1C1(O)CCN(C(=O)OC(C)(C)C)CC1>>Cc1onc(-c2ccccc2)c1C1=CCNCC1,,O,,O=C([O-])O.[Na+],,val
US20090220381A1,O=C(O)CCCCCCCCCCBr.O=[N+]([O-])c1ccccc1CO>>O=C(CCCCCCCCCCBr)OCc1ccccc1[N+](=O)[O-],CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20080269194A1,NC(Cc1ccccc1Cl)C(=O)O.O=c1[nH]c2ccc(Cl)cc2c(=O)o1>>O=C1NC(Cc2ccccc2Cl)C(=O)Nc2ccc(Cl)cc21,,CC#N,O,CCN(CC)CC,Cl,val
US20120157459A1,BrCc1ccccc1.O=C1CCc2c(O)cccc21>>O=C1CCc2c(OCc3ccccc3)cccc21,,CN(C)C=O,CN(C)C=O,[H-].[Na+],[Cl-].[NH4+],val
US20050038072A1,C1CC2(CCN1)OCCO2.FC(F)(F)c1cc(CBr)cc(C(F)(F)F)c1>>O=C1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020188000A1,COc1cccc(-c2cnc3cc(C)ccn23)c1>>Cc1ccn2c(-c3cccc(O)c3)cnc2c1,,Br,CC(=O)O,[Na+].[OH-],,val
US20110092531A1,CC#C[C@@H](CC(=O)OCC)c1ccc(OCc2ccc(CBr)cc2)cc1.CN1CC2(CCNCC2)c2ccccc21>>CC#C[C@@H](CC(=O)OCC)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070213341A1,CCCI.Oc1ccc(F)c(F)c1>>CCCOc1ccc(F)c(F)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160159752A1,CC(C)(C)OC(=O)N1C[C@H](/C=C/c2c(F)cccc2[N+](=O)[O-])NC2(CC2)C1.O=S(=O)(Cl)c1ccccc1>>CC(C)(C)OC(=O)N1C[C@H](/C=C/c2c(F)cccc2[N+](=O)[O-])N(S(=O)(=O)c2ccccc2)C2(CC2)C1,,ClCCl,,CCN(CC)CC,,val
US20160166560A1,COc1ccc(N2CCC(N(C)C(=O)n3cnc(-c4ccc(OCc5ccccc5)cc4)c3)CC2)cc1>>COc1ccc(N2CCC(N(C)C(=O)n3cnc(-c4ccc(O)cc4)c3)CC2)cc1,,ClCCl,,Br,,val
US06423689B1,BrCC1CCCCC1.CC(C)CC(NC(=O)N1CCCCCC1)C(=O)NC(Cc1ccc(O)cc1)C(=O)OC(C)(C)C>>CC(C)CC(NC(=O)N1CCCCCC1)C(=O)NC(Cc1ccc(OCC2CCCCC2)cc1)C(=O)OC(C)(C)C,,CN(C)C=O,O,CCOC(C)=O,[H-].[Na+],val
US20150094297A1,CC(F)(F)c1nnc(N)s1.O=C(CBr)c1cc2c(OCc3ccccc3)nccc2o1>>CC(F)(F)c1nn2cc(-c3cc4c(O)nccc4o3)nc2s1,,ClCCl,,CC(C)O,,val
US07307098B2,COc1ccc(NC(=O)OC(C)(C)C)c(C#CCCCCCCCCCCCCCCO[Si](C)(C)C(C)(C)C)c1>>COc1ccc2[nH]c(CCCCCCCCCCCCCCO)cc2c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090124610A1,O=C1Nc2nccc(Cl)c2C1(Br)Br>>O=C1Cc2c(Cl)ccnc2N1,[Pd],CCO,,,,val
US20080255240A1,Cc1cc(C(C)(C)C)c(O)c(S(N)(=O)=O)c1.O=[N+]([O-])c1ccc(F)c(Cl)c1>>Cc1cc(C(C)(C)C)c(O)c(S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2Cl)c1,,CCO,,,,val
US20030229102A1,N#Cc1ccc(CCCNC(=O)OCc2ccccc2)cc1F>>N#Cc1ccc(CCCN)cc1F,[Pd],,,,,val
US20090182023A1,CC(=O)NCCC1CCc2ccc(N)c(O)c21.O=C(Cl)CCCCOCc1ccccc1>>CC(=O)NCCC1CCc2ccc(NC(=O)CCCCOCc3ccccc3)c(O)c21,,c1ccncc1,,Cl,,val
US04404389,CCN(CC)c1ccc2cc(C(N)=S)c(=O)oc2c1.O=C(CBr)c1ccccc1>>CCN(CC)c1ccc2cc(-c3nc(-c4ccccc4)cs3)c(=O)oc2c1,,CCN(CC)CC,,CC(C)O,,val
US20100216788A1,O=Cc1cccc(OCc2ccccc2)c1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>c1ccc(COc2cccc(-c3cnco3)c2)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20140018313A1,CC(C)(C)OC(=O)N1CCCC1c1ncc(-c2ccc3cc(Br)ccc3c2)[nH]1.COC(=O)NC(C(=O)N1C2CCC(C2)C1c1ncc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)[nH]1)C1CCOCC1>>COC(=O)NC(C(=O)N1C2CCC(C2)C1c1ncc(-c2ccc(-c3ccc4cc(-c5cnc(C6CCCN6C(=O)OC(C)(C)C)[nH]5)ccc4c3)cc2)[nH]1)C1CCOCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US05919807,COc1ccc(N)c(S)c1.O=C(Br)CBr>>COc1ccc2nc(CBr)sc2c1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20150225342A1,CC(C)(C)c1ccc(C2(O)CC3CN(C(=O)OCc4ccccc4)CC3C2)cc1>>CC(C)(C)c1ccc(C2(O)CC3CNCC3C2)cc1,[Pd],CCO,,,,val
US20150274696A1,CC(C)(O)C(F)CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1Nc1ccc(C(=O)O)cc1.CN>>CNC(=O)c1ccc(Nc2cc(Nc3ccc4ncsc4c3)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cc1,,CC#N,O,O=C(O)C(F)(F)F,,val
US20090029975A1,CC(C)(C)OC(=O)CCc1cc(Cl)ccn1.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)CCc1cc(Cl)cc[n+]1[O-],,CCOC(C)=O,,,,val
US20120330024A1,CCCC[Sn](CCCC)(CCCC)c1cccc(-c2ccc(C=O)o2)c1.CCOC(=O)CN1C(=O)CSC1=S>>CCCC[Sn](CCCC)(CCCC)c1cccc(-c2ccc(/C=C3\SC(=S)N(CC(=O)OCC)C3=O)o2)c1,,ClCCl,,C1CCNCC1,,val
US05852128,C=COCCO.CC(=O)Cl>>C=COCCOC(C)=O,,O,,CCN(CC)CC,CCOCC,val
US20120058984A1,CSc1nccc(N)n1.Clc1nc2ccc(Br)cc2s1>>CSc1nccc(Nc2nc3ccc(Br)cc3s2)n1,,C1CCOC1,,O,[H-].[Na+],val
US20140323470A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)cc1.N[C@H]1CC[C@@H](Oc2ccc3nnc(N4CCCCCC4)n3c2)c2ccccc21>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCCC5)n4c3)c3ccccc32)cc1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US04352806,Cc1nc(C(Cl)(Cl)Cl)nc(O)c1Cl.O=C(Cl)c1ccccc1F>>Cc1nc(C(Cl)(Cl)Cl)nc(OCc2ccccc2F)c1Cl,,CCOCC,,CCN(CC)CC,,val
US05294608,CCOP(=O)(OCC)C(CCCNC=NN(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)P(=O)(OCC)OCC>>NN=CNCCCC(P(=O)(O)O)P(=O)(O)O,,Cl,,,,val
US05747000,CC(C)(C)OCCBr.O=C(O)CN1CCNCCN(CC(=O)O)CCN(CC(=O)O)CC1>>CC(C)(C)OCCN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100273764A1,CC(C)(O)C(C)(C)O.OB(O)c1cc(C2OCCO2)cnc1F>>CC1(C)OB(c2cc(C3OCCO3)cnc2F)OC1(C)C,,Cc1ccccc1,,O=S(=O)([O-])[O-].[Mg+2],,val
US20160002215A1,Cc1nnc(-c2cc([N+](=O)[O-])cc(C(F)(F)F)c2)o1>>Cc1nnc(-c2cc(N)cc(C(F)(F)F)c2)o1,[Pd],CO,,,,val
US05756545,CC(C)C(NS(=O)(=O)c1ccc(Br)cc1)C(=O)OC(C)(C)C.COc1ccc(B(O)O)cc1>>COc1ccc(-c2ccc(S(=O)(=O)NC(C(=O)OC(C)(C)C)C(C)C)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,Cc1ccccc1,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20090163512A1,C#C[Si](C)(C)C.COB(OC)OC>>COB(C#C[Si](C)(C)C)OC,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20130029969A1,NC(=O)c1sc(Br)cc1NC(=O)C(c1ccccc1)N1CCCC1>>O=c1[nH]c(C(c2ccccc2)N2CCCC2)nc2cc(Br)sc12,,COCCOC,,[Na+].[OH-],,val
US20110288067A1,CC(C)(C)OC(=O)Oc1ccc2c(ccn2C(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)n1ccc2cc(O)ccc21,,ClCCl,,C1COCCN1,,val
US04487726,N=C(N)NCCC[C@H](N)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O>>N=C(N)NCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O,,O,,,,val
US20150001471A1,Brc1cccc2c1[nH]c1ccccc12.Clc1nc(-c2ccccc2)nc(-c2ccc(-c3ccccc3)cc2)n1>>Brc1cccc2c3ccccc3n(-c3nc(-c4ccccc4)nc(-c4ccc(-c5ccccc5)cc4)n3)c12,,CN(C)C=O,O,CO,[H-].[Na+],val
US20060135578A1,CCOP(=O)(CP(=O)(OCC)OCC)OCC.CN(C)C=O.COc1cc(COc2nn(-c3ccccc3)cc2C=O)ccc1OCc1nc(-c2cccc(OCC(=O)[O-])c2)oc1C>>CCOP(=O)(/C=C/c1cn(-c2ccccc2)nc1OCc1ccc(OCc2nc(-c3cccc(OCC(=O)OC)c3)oc2C)c(OC)c1)OCC,,O,,[H-].[Na+],,val
US20030166639A1,Cc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3cccnc3C)c2)cc1C(F)(F)F>>Cc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3cccnc3C)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040147519A1,COC(=O)C[C@@H](Nc1ccccc1[N+](=O)[O-])C(=O)OC>>COC(=O)C[C@H]1Nc2ccccc2NC1=O,O=[Pt]=O,CO,,,,val
US20050148623A1,CC(C)(C)OC(=O)[C@@H](N1CCNC1=O)C(C)(C)C>>CC(C)(C)[C@@H](C(=O)O)N1CCNC1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120214785A1,CC(=O)OC(C)=O.CC(N)Cc1ccc(O)cc1>>CC(=O)NC(C)Cc1ccc(O)cc1,,CC#N,O,O=C([O-])O.[Na+],,val
US20150166480A1,COC(=O)c1ccc(-c2cnc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)nc2)cc1>>O=C(O)c1ccc(-c2cnc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)nc2)cc1,,C1CCOC1,,O,[Li]O,val
US04495198,CCN.Cl.O=c1cc(-c2ccccc2)oc2cc(OCC3CO3)ccc12>>CCNCC(O)COc1ccc2c(=O)cc(-c3ccccc3)oc2c1.Cl,,CO,,CCO,,val
US20110009454A1,N#Cc1cccc(F)c1.Oc1ccc(F)cc1>>N#Cc1cccc(Oc2ccc(F)cc2)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20130231358A1,CCN(CC)CC.COC(=O)c1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncnc(Cl)c21>>CCN(CC)CC.COC(=O)c1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncncc21.Cl,[Pd],CCOC(C)=O,,,,val
US20040116424A1,C=O.CCCCn1cc(-c2ccc(OC)cc2)nc1-c1ccccc1>>CCCCn1c(-c2ccccc2)nc(-c2ccc(OC)cc2)c1CO,,CC(=O)O,,,,val
US20090192156A1,O=C(O)Cc1cccc(Br)c1.O=S(Cl)Cl>>O=C(Cl)Cc1cccc(Br)c1,,ClCCl,,,,val
US20100075961A1,CCC=C(OC)O[Si](C)(C)C.OC(c1ccccc1)c1ccc2c(cnn2-c2ccc(F)cc2)c1>>CCC(C(=O)OC)C(c1ccccc1)c1ccc2c(cnn2-c2ccc(F)cc2)c1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20140350019A1,Cc1c(F)cc(-c2cccc(F)c2)cc1[N+](=O)[O-]>>Cc1c(N)cc(-c2cccc(F)c2)cc1F,[Pd],CCO,,,,val
US20050014765A1,CCOC(=O)CCCBr.COc1cc(OC)cc(N2CCN(C(=O)c3c[nH]cc3-c3ccccc3)CC2)c1>>COc1cc(OC)cc(N2CCN(C(=O)c3cn(CCCC(=O)O)cc3-c3ccccc3)CC2)c1,,Cc1ccccc1,c1ccncc1,[H-].[Na+],,val
US20060264628A1,Cc1nc2c(s1)C(=O)C(=CN1CCOCC1)CC2.N=C(N)N>>Cc1nc2c(s1)-c1nc(N)ncc1CC2,,CCO,,Cl,[Na+].[OH-],val
US20100076034A1,CC(F)(C(=O)O)c1ccc(OS(=O)(=O)C(F)(F)F)cc1.CON>>CONC(=O)C(C)(F)c1ccc(OS(=O)(=O)C(F)(F)F)cc1,,O=S(Cl)Cl,,Cl,,val
US20140221417A1,C=Cc1cccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N(C)c2ccc(OC)cc2)c1.CC(O)=S>>COc1ccc(N(C)C(=O)[C@H](Cc2cccc(CCSC(C)=O)c2)NC(=O)OC(C)(C)C)cc1,,Cc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20100016328A1,CC(O)C(O)C1CNc2[nH]c(N)nc(=O)c2N1.O=C(Cl)OCc1ccccc1>>CC(O)C(O)C1CNc2[nH]c(N)nc(=O)c2N1C(=O)OCc1ccccc1,,c1ccncc1,,Cl,Cl,val
US20100016318A1,C[C@@H](N)CO.Nc1cccc([N+](=O)[O-])c1.O=C(Cl)CCl>>C[C@H](CO)NCC(=O)Nc1cccc([N+](=O)[O-])c1,,CCOC(C)=O,O,O=C([O-])O.[K+],,val
US06265403B1,Brc1cncc(-c2ccsc2)c1.Cc1ccc(S(=O)(=O)n2cc(B(O)O)c3ccccc32)cc1>>Cc1ccc(S(=O)(=O)n2cc(-c3cncc(-c4ccsc4)c3)c3ccccc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US06001860,CCCCC(CN)c1ccccc1C.CSc1cc(C)nc(SC)c1N=C=O>>CCCCC(CNC(=O)Nc1c(SC)cc(C)nc1SC)c1ccccc1C,,CCOC(C)=O,CN(C)C=O,,,val
US20100144695A1,CNC.CS(=O)(=O)c1ncc(C2(O)CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)s1>>CN(C)c1ncc(C2(O)CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)s1,,CN(C)C=O,,,,val
US20130338140A1,CC(C)(C)S(=O)/N=C/c1cnco1.Fc1cc(Br)ccc1OC(F)(F)F>>CC(C)(C)S(=O)NC(c1ccc(OC(F)(F)F)c(F)c1)c1cnco1,,C1CCOC1,Cc1ccccc1,II,,val
US20110015212A1,Cc1csc2nc(C(C)N=[N+]=[N-])c(Br)c(=O)n12.OB(O)c1cc(F)cc(Cl)c1>>Cc1csc2nc(C(C)N=[N+]=[N-])c(-c3cc(F)cc(Cl)c3)c(=O)n12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,O,O=C([O-])[O-].[Na+].[Na+],val
US20070167433A1,COCCCN1C(=O)COc2ccc(C=C[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)C[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]3c3ccc(C(=O)OC)cc3)cc21>>COCCCN1C(=O)COc2ccc(CC[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)C[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]3c3ccc(C(=O)OC)cc3)cc21,[Pd],CCO,,,,val
US20150182537A1,COC(=O)CC#N.COc1ccc(C=O)cn1>>COC(=O)/C(C#N)=C\c1ccc(OC)nc1,,CO,,C1CCNCC1,,val
US05155106,CCCCCCCCSCCN.CCCc1c(OC)ccc(C(=O)O)c1O.CCOC(=O)Cl>>CCCCCCCCSCCNC(=O)c1ccc(OC)c(CCC)c1OC(=O)OCC,,ClCCl,,CCN(CC)CC,,val
US20120071467A1,CCc1nc(NCCCCCC(=O)N(C)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)sc1C(=O)O>>CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCCCCNc1ncc(C(=O)O)s1,,CCO,,Cl,[Na+].[OH-],val
US20130059899A1,CCOC(=O)CCc1c(C(=O)OCC)[nH]c2cc(I)ccc12>>O=C(O)CCc1c(C(=O)O)[nH]c2cc(I)ccc12,,C1CCOC1,O,[Li+].[OH-],,val
US07378409B2,CC(C)OC(=O)[C@@H]1C[C@H](N(C(=O)OC(C)(C)C)C(C)C)CC[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1>>CC(C)N[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](C(=O)OC(C)C)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070078165A1,CCOc1nc2cc(C)ccc2n1C1CCN(C(=O)OC(C)(C)C)CC1>>CCOc1nc2cc(C)ccc2n1C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030109459A1,COCCC1(C(=O)N[C@@H](Cc2ccc(NC(=O)c3c(Cl)cccc3Cl)cc2)C(=O)OC)CCCC1>>COCCC1(C(=O)N[C@@H](Cc2ccc(NC(=O)c3c(Cl)cccc3Cl)cc2)C(=O)O)CCCC1,,C1CCOC1,CCO,[Na+].[OH-],,val
US05849757,CCOC(=O)C1([C@H]2CCN(C(=O)OCc3ccccc3)C2)CC1>>O=C(OCc1ccccc1)N1CC[C@H](C2(C(=O)O)CC2)C1,,CCO,,[Na+].[OH-],,val
US20070167442A1,CS(=O)(=O)c1ccc2c(c1)ncn2C1CCNCC1.O=C(CCCl)c1ccccc1>>CS(=O)(=O)c1ccc2c(c1)ncn2C1CCN(CCC(=O)c2ccccc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150344494A1,Cc1n[nH]c2cc(B(O)O)ccc12.O=c1cc(N2CCOCC2)oc2c(Br)csc12>>Cc1n[nH]c2cc(-c3csc4c(=O)cc(N5CCOCC5)oc34)ccc12,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],,val
US06083908,CC(=O)OC(C)=O.CN(N)C(=O)OC(C)(C)C>>CC(=O)NN(C)C(=O)OC(C)(C)C,,ClCCl,,c1ccncc1,,val
US20130252934A1,CI.O=c1cc(-c2nc(NC3CCOCC3)ncc2F)ccn1C(c1cn[nH]c1)c1ccc(Cl)c(F)c1>>Cn1cc(C(c2ccc(Cl)c(F)c2)n2ccc(-c3nc(NC4CCOCC4)ncc3F)cc2=O)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20120053147A1,CC(=O)O[C@@H](C)C(=O)Cl.Cc1c(Cl)cccc1CNc1nc(N2CCOCC2)sc1C(N)=O>>CC(=O)O[C@@H](C)c1nc(=O)c2sc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1C,,C1CCOC1,,,,val
US20110172236A1,CC(C)([C@@H]1CCNC(=O)C1)S(=O)(=O)c1cccc(C(F)(F)F)c1.Fc1cc(C(F)(F)F)cnc1F>>CC(C)([C@@H]1CCN(c2ncc(C(F)(F)F)cc2F)C(=O)C1)S(=O)(=O)c1cccc(C(F)(F)F)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20100249119A1,C1CSCCN1.CN(c1cccc(NC(=O)c2cccc(C(C)(C)C#N)c2)c1)c1ncc2nc(NC(=O)CCl)sc2n1>>CN(c1cccc(NC(=O)c2cccc(C(C)(C)C#N)c2)c1)c1ncc2nc(NC(=O)CN3CCSCC3)sc2n1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20110245205A1,CC(C)P1(=O)CCN(Cc2ccccc2)CC1.O=C(O)C(=O)O>>CC(C)P1(=O)CCNCC1.O=C(O)C(=O)O,[Pd],O,,CCO,,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccsc4)nc(Cl)c3n2)cc1.Nc1ccc2c(c1)NCCO2>>c1cc(-c2nc(Nc3ccc4c(c3)NCCO4)c3[nH]ncc3n2)cs1,C1COCCO1,CO,,Cl,,val
US05459138,CN1C=NS(=O)(=O)c2ncccc21>>CN1CNS(=O)(=O)c2ncccc21,,CC(C)O,,[BH4-].[Na+],,val
US05795894,NC1CCN(Cc2ccccc2)CC1.OCCBr>>OCCNC1CCN(Cc2ccccc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090076074A1,COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1.CS(=O)(=O)O>>COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1.CS(=O)(=O)O,,CCOC(C)=O,,CCO,,val
US20070099944A1,CC1=C(C(=O)O)C(c2ccc(F)c(F)c2)NC(=O)N1.Nc1ccc2[nH]nc(Nc3ccc(F)cc3)c2c1>>CC1=C(C(=O)Nc2ccc3[nH]nc(Nc4ccc(F)cc4)c3c2)C(c2ccc(F)c(F)c2)NC(=O)N1,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US04116956,CCOC(C)=N.NNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NC1>>Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2,,ClC(Cl)Cl,,Cl,O=C([O-])O.[Na+],val
US20100029718A1,Cc1nc(N)sc1C(=O)NCc1ccccc1.O=C(Cl)CCCCBr>>Cc1nc(NC(=O)CCCCBr)sc1C(=O)NCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20030119868A1,N#CBr.Nc1ccc(-c2ccccc2)cc1N>>Nc1nc2cc(-c3ccccc3)ccc2[nH]1,,C1CCOC1,,CO,O,val
US05629428,CCCCCCCCOc1ccc(-c2ncc(O)cc2Cl)cc1.CCCCC[C@@H]1CC[C@@H](C(=O)O)CC1>>CCCCCCCCOc1ccc(-c2ncc(OC(=O)[C@@H]3CC[C@@H](CCCCC)CC3)cc2Cl)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130116234A1,COC(=O)c1c(C(C)C)nc2c(Cl)cc(Cl)cc2c1O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1c(C(C)C)nc2c(Cl)cc(Cl)cc2c1OS(=O)(=O)C(F)(F)F,,CN(C)C=O,O,[H-].[Na+],,val
US20160200674A1,Cc1ccc(NC(=O)Nc2c(N(CC(C)C)CC(C)C)ccc(Br)c2F)cc1.OB(O)c1ccccc1-c1nnn[nH]1>>Cc1ccc(NC(=O)Nc2c(N(CC(C)C)CC(C)C)ccc(-c3ccccc3-c3nnn[nH]3)c2F)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US20030044718A1,C=CC(=O)Cl.C[C@@H]1CC[C@H]2C(C)(C)[C@H]3C[C@]21CC[C@@]3(C)O.O>>C=CC(=O)[O-].C[C@@H]1CC[C@H]2C(C)(C)[C@H]3C[C@]21CC[C@@]3(C)O,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20100016388A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCc1ccccc1Cl>>CC(C)(C)OC(=O)NCCc1ccccc1Cl,,C1CCOC1,,CCN(CC)CC,,val
US20100029611A1,COC(=O)[C@@H]1C[C@H](c2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)CN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1C[C@@H](c2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)C[C@H]1C(=O)O,,C1CCOC1,O,[Na+].[OH-],,val
US20040147535A1,COC(=O)c1ccccc1N.O=Cc1ccnc(Br)c1>>COC(=O)c1ccccc1NCc1ccnc(Br)c1,,CO,O,CC(=O)O,[BH3-]C#N.[Na+],val
US20090239848A1,O=c1[nH]c2cc([N+](=O)[O-])ccc2o1>>Nc1ccc2oc(=O)[nH]c2c1,[Pd],CO,,,,val
US20090018166A1,CC(C)(C)OC(=O)C1CCN(c2nc(CN3CCCC3=O)c(C(=O)Cl)cc2C#N)CC1.C[Mg]Cl>>CC(=O)c1cc(C#N)c(N2CCC(C(=O)OC(C)(C)C)CC2)nc1CN1CCCC1=O,,C1CCOC1,,,,val
US20040127494A1,COC(=O)c1ccc(N(C)C)nc1>>CN(C)c1ccc(CO)cn1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06235707B1,CCOC(=O)Cl.NC(CC1CCC1)C(=O)O>>CCOC(=O)NC(CC1CCC1)C(=O)O,,[Na+],[OH-],,,val
US20120040981A1,BrBr.Cc1[nH]ncc1-c1cc2c(s1)C(=O)NC(C)(C)N2>>Cc1[nH]ncc1-c1sc2c(c1Br)NC(C)(C)NC2=O,,CC(=O)O,,O=C([O-])O.[Na+],,val
US20100239526A1,COc1ccc(Cn2ncc3c4c(cnc32)CN(C(=O)[C@@H]([NH3+])c2ccccc2)CC4)cc1.O=C([O-])C(F)(F)F>>O=C([O-])C(F)(F)F.[NH3+][C@H](C(=O)N1CCc2c(cnc3[nH]ncc23)C1)c1ccccc1,,Cc1ccccc1,,O=C(O)C(F)(F)F,,val
US20060089370A1,CCS(=O)([O-])=S.Clc1ncnc2scc(Br)c12>>CSc1csc2ncnc(Cl)c12,,C1CCOC1,,CC(C)[Mg]Cl,,val
US04027023,CCN(CC)CCO.O=C(Cl)c1cc2cc(Br)ccc2nn1>>CCN(CC)CCOC(=O)c1cc2cc(Br)ccc2nn1,,C1CCOC1,,,,val
US04198511,COC(=O)c1cc(=O)c2c([nH]1)c(=O)oc1ccccc12>>O=C(O)c1cc(=O)c2c([nH]1)c(=O)oc1ccccc12,,Cl,,,,val
US20130072467A1,CC(c1ccc(C(F)(F)F)cc1C(F)(F)F)N1CCC(CO)CC1>>CC(c1ccc(C(F)(F)F)cc1C(F)(F)F)N1CCC(C=O)CC1,,CS(C)=O,,CCN(CC)CC,O,val
US20110152532A1,COC(=O)C1(O)CC(CO)=NN1c1ncccc1Cl.CS(=O)(=O)Cl>>COC(=O)c1cc(COS(C)(=O)=O)nn1-c1ncccc1Cl,,C1CCOC1,O,CCN(CC)CC,,val
US20090137609A1,CCC(CC)(c1ccc(C#CC(OCOC)(C(F)(F)F)C(F)(F)F)c(C)c1)c1ccc(B2OC(C)(C)C(C)(C)O2)c(C)c1>>CCC(CC)(c1ccc(C#CC(O)(C(F)(F)F)C(F)(F)F)c(C)c1)c1ccc(B2OC(C)(C)C(C)(C)O2)c(C)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160021883A1,FC(F)(F)Oc1ccc(-n2cnc(-c3ccc(N=C=S)cc3)n2)cc1.Nc1cnccc1C(F)(F)F>>FC(F)(F)Oc1ccc(-n2cnc(-c3ccc(NC(=S)Nc4cnccc4C(F)(F)F)cc3)n2)cc1,,C1CCOC1,,[H-].[Na+],,val
US05866567,O=C(Nc1ccc(CN2C(=O)[C@H]3CCC[C@H]3N(C(=O)CBr)c3ccccc32)cc1)OCc1ccccc1.O=C1NC(=O)c2ccccc21>>O=C(Nc1ccc(CN2C(=O)[C@H]3CCC[C@H]3N(C(=O)CN3C(=O)c4ccccc4C3=O)c3ccccc32)cc1)OCc1ccccc1,,CN(C)C=O,O,[K],,val
US20060025400A1,Cc1ccc(S(=O)(=O)N2C=CNC(=O)C2CC(=O)O)cc1.NCCc1ccc(CO)cc1>>Cc1ccc(S(=O)(=O)N2C=CNC(=O)C2CC(=O)NCCc2ccc(CO)cc2)cc1,,CN(C)C=O,ClCCl,ClCCCl,On1nnc2ccccc21,val
US20150051395A1,COc1ccc2c(c1)c(=O)n(-c1ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(C(=O)NC5CC5)cc4)cc3F)C(=O)OC(C)C)cc1)c(=O)n2C>>COc1ccc2c(c1)c(=O)n(-c1ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(C(=O)NC5CC5)cc4)cc3F)C(=O)O)cc1)c(=O)n2C,,O,,C1COCCO1,Cl,val
US20120165305A1,Clc1cnn2ccnc2c1.O=C1CCC(=O)N1I>>Clc1cnn2c(I)cnc2c1,,CCOC(C)=O,CN(C)C=O,,,val
US20130143907A1,CCOC(=O)c1cnn(C2CCOCC2)c1-c1cc(F)c(-c2c(C)cc(C)nc2OC)cc1F>>COc1nc(C)cc(C)c1-c1cc(F)c(-c2c(C(=O)O)cnn2C2CCOCC2)cc1F,,CCO,,[Na+].[OH-],,val
US20050107388A1,COC(Cl)Cl.COc1cc(F)cc(F)c1>>COc1cc(F)cc(F)c1C=O,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20100216788A1,CC(C)(C)[Si](C)(C)OCCn1ccc2ncnc(Cl)c21.Nc1ccc(Oc2cccc(S(=O)(=O)CC(F)(F)F)c2)c(Cl)c1>>O=S(=O)(CC(F)(F)F)c1cccc(Oc2ccc(Nc3ncnc4ccn(CCO)c34)cc2Cl)c1,,CC(C)O,,,,val
US05962682,COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc(C(=O)NCC(=O)OCc2ccccc2)cc1OCCOC(=O)Nc1ccccn1>>COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc(C(=O)NCC(=O)O)cc1OCCOC(=O)Nc1ccccn1,[Pd],CO,,,,val
US20130129753A1,CC(C)(CN)C(=O)O.O=C(Cl)OCC1c2ccccc2-c2ccccc21>>CC(C)(CNC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20030109700A1,COC(=O)c1cccnc1Cl.OB(O)c1ccc(C(F)(F)F)cc1>>COC(=O)c1cccnc1-c1ccc(C(F)(F)F)cc1,[Pd],,,,,val
US04939133,COc1ccc(CCc2ccc(N)cc2)cc1OC.O=C1Oc2ccccc2C1=O>>COc1ccc(CCc2ccc(NC(=O)C(=O)c3ccccc3O)cc2)cc1OC,,C1CCOC1,,,,val
US20140080798A1,Cc1cnc(Nc2ccc(C(C)NC(=O)OC(C)(C)C)cc2)nc1CCc1ccccc1CC(N)=O>>Cc1cnc(Nc2ccc(C(C)N)cc2)nc1CCc1ccccc1CC(N)=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04460596,CCOC(=O)CC(NC(=O)c1ccccc1)C(=O)c1ccsc1>>CCOC(=O)Cc1nc(-c2ccccc2)oc1-c1ccsc1,,CN(C)C=O,,O=P(Cl)(Cl)Cl,,val
US20150274718A1,COC(=O)C(OC(C)(C)C)c1c(C(F)(F)F)ccc(OCc2ccccc2)c1-c1ccc2c(c1)CCCO2>>COC(=O)C(OC(C)(C)C)c1c(C(F)(F)F)ccc(O)c1-c1ccc2c(c1)CCCO2,,CCOC(C)=O,,,,val
US20060052379A1,CCn1nc(-c2ccccc2)c2c(C)onc2c1=O>>CCn1nc(-c2ccccc2)c(C(C)=O)c(N)c1=O,[Pd],CCO,,,,val
US04526978,CCOC(=O)CN=[N+]=[N-].Cc1ccc(S(=O)(=O)C#N)cc1>>CCOC(=O)Cn1nnnc1S(=O)(=O)c1ccc(C)cc1,,c1ccccc1,,,,val
US20090137804A1,Cc1ccc([N+](=O)[O-])cc1NC(=O)N(C)c1cc(NC(=O)OC(C)(C)C)ncn1>>Cc1ccc(N)cc1NC(=O)N(C)c1cc(NC(=O)OC(C)(C)C)ncn1,[Pd],CN(C)C=O,CO,,,val
US20060287309A1,Clc1cccc(N2CCNCC2)c1Cl.O=CCCCOc1ccc2c(n1)NC(=O)CC2>>O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nc2N1,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05116846,O=C(Cc1ccc(F)cc1)C1CCN(Cc2ccccc2)CC1.O=C(O)/C=C\C(=O)O>>O=C(Cc1ccc(F)cc1)C1CCN(Cc2ccccc2)CC1.O=C(O)/C=C\C(=O)O,,CCOCC,,,,val
US20100093730A1,O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O.c1ccc(C2(c3ccccc3)CCNC2)cc1>>O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)N1CCC(c2ccccc2)(c2ccccc2)C1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20140134133A1,C[Si](C)(C)C#Cc1cnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)nn12>>C#Cc1cnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)nn12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100160303A1,CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(-c4cccc5c(C(=O)c6ccc(F)cc6)cccc45)c23)CC1>>NC(=O)c1cccc2c1[nH]c1ccccc12,Cl,CCO,,[BH4-].[Na+],,val
US05739345,Cn1c(COc2ccc(C=O)cc2)nc2cccnc21.O=C1CSC(=O)N1>>Cn1c(COc2ccc(C=C3SC(=O)NC3=O)cc2)nc2cccnc21,,CCO,,C1CCNCC1,,val
US20040039038A1,O=Cc1ccc(-c2ccccc2)cc1CNC(=O)c1ccccc1.OCCO>>O=C(NCc1cccc(-c2ccc(C3OCCO3)cc2)c1)c1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,O,,Cc1ccccc1,,val
US03934008,COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(N)=O.NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1>>COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)OCc1ccccc1,,CCN(CC)CC,CN(C)C=O,Cl,,val
US20060094750A1,CC(C)(C)Cc1nc2cc(CCl)ccc2n1CC1CC1.CC(C)S>>CC(C)SCc1ccc2c(c1)nc(CC(C)(C)C)n2CC1CC1,,CN(C)C=O,,O,[H-].[Na+],val
US04863958,C=CCc1ccc2oc(CCc3ccc(OC)cc3)c(C)c2c1O>>CCCc1ccc2oc(CCc3ccc(OC)cc3)c(C)c2c1O,[Pd],CCO,,,,val
US20130019348A1,O=C(O)c1ccc(-c2ncn(-c3ccc(C(F)(F)C(F)(F)C(F)(F)F)cc3)n2)cc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=NC(=O)c1ccc(-c2ncn(-c3ccc(C(F)(F)C(F)(F)C(F)(F)F)cc3)n2)cc1,,CC(C)O,,CCN(CC)CC,,val
US20090062529A1,COc1nc(/C=C(\C)C(=O)OC(C)(C)C)ccc1-n1cnc(C)c1>>COc1nc(/C=C(\C)C(=O)O)ccc1-n1cnc(C)c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100022544A1,C/C(N)=C/C#N.N#CCC#N.O=CC1CCCCO1>>Cc1nc(N)c(C#N)c(C2CCCCO2)c1C#N,,CCO,,C[O-].[Na+],,val
US20120225884A1,C=O.CO.NCc1ccccc1.O=C1CCOC1>>O=C1C2COC1CN(Cc1ccccc1)C2,,CO,,CC(=O)O,,val
US20120214803A1,O=C(c1ccc(OC(F)(F)F)cc1)c1ccc2cccnc2c1[N+](=O)[O-]>>Nc1c(C(=O)c2ccc(OC(F)(F)F)cc2)ccc2cccnc12,[Pd],C1CCOC1,,,,val
US05051509,COc1c(F)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12.NCC1CCCNC1>>COc1c(N2CCCC(CN)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,,CC#N,CN(C)C=O,CCN(CC)CC,,val
US20060084680A1,CCCc1cc(C#N)ccc1OCc1ccccc1.S>>CCCc1cc(C(N)=S)ccc1OCc1ccccc1,,CN(C)C=O,,CCNCC,,val
US20060264440A1,Clc1ncnc2ccc(I)cc12.N>>Nc1ncnc2ccc(I)cc12,,CO,,,,val
US20120129840A1,CCCC(C(=O)OC)c1c(C)nc(-c2ccccc2)nc1Cl.OB(O)c1ccc2c(c1)OCCCO2>>CCCC(C(=O)OC)c1c(C)nc(-c2ccccc2)nc1-c1ccc2c(c1)OCCCO2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,CCN(C(C)C)C(C)C,,val
US06664214B1,CCOC(=O)C(C)Oc1ccccc1COc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl>>COC(=O)C(C)Oc1ccccc1COc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl,,Cl,,CO,C[O-].[Na+],val
US20150335632A1,O=[N+]([O-])c1cnc2ccc(Cl)c(F)c2c1Br>>Nc1cnc2ccc(Cl)c(F)c2c1Br,[Fe],CC(=O)O,CCOC(C)=O,,,val
US05424444,CC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=C[C@@H]1CCCN1C(=O)OCc1ccccc1>>CC(=O)C=CC1CCCN1C(=O)OCc1ccccc1,,c1ccccc1,,,,val
US20100317693A1,NC1Cc2cccc(N3CCCC3=O)c2N(Cc2ccccc2)C1=O.O=C(O)[C@@H](O)[C@H](O)C(=O)O>>NC1Cc2cccc(N3CCCC3=O)c2N(Cc2ccccc2)C1=O.O=C(O)[C@@H](O)[C@H](O)C(=O)O,,CO,O,,,val
US20060135534A1,N#Cc1ccc(NCCN)nc1.O=[N+]([O-])c1ncc(Br)nc1-c1ccc(Cl)cc1Cl>>N#Cc1ccc(NCCNc2cnc([N+](=O)[O-])c(-c3ccc(Cl)cc3Cl)n2)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04009166,CCOC(OCC)N(C)C.O=C1NCc2cccnc2N1c1cccc(C(F)(F)F)c1>>CCN1Cc2cccnc2N(c2cccc(C(F)(F)F)c2)C1=O,,O,,CN(C)C=O,,val
US20110218192A1,CC(C)(C)S(=O)(=O)/N=C1\CC2(CCCCC2)Oc2ccc(Br)cc21.COC(C)=O>>COC(=O)CC1(NS(=O)C(C)(C)C)CC2(CCCCC2)Oc2ccc(Br)cc21,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US04695654,Cc1ccccc1S(=O)(=O)Cl.NCC(F)(F)CCOCc1ccccc1>>Cc1ccc(S(=O)(=O)NCC(F)(F)CCOCc2ccccc2)cc1,,CCOCC,ClCCl,CCN(CC)CC,,val
US20160024083A1,CCCBr.c1cnc2c(c1)[nH]c1ccc(-c3nnco3)cc12>>CCCn1c2ccc(C#N)cc2c2ncccc21,,CN(C)C=O,,[H-].[Na+],,val
US20080255197A1,Cc1cnc(CN(Cc2ncccc2C(C)(C)c2ccccc2)C2CCNCC2)c(C)c1.O=C(NO)Oc1ccccc1>>Cc1cnc(CN(Cc2ncccc2C(C)(C)c2ccccc2)C2CCN(C(=O)O)CC2)c(C)c1,,C1CCOC1,,,,val
US06187777B1,Cc1nc(Cl)c2[nH]c(-c3ccccc3)cc2n1.NCCOc1ccccc1>>Cc1nc(NCCOc2ccccc2)c2nc(-c3ccccc3)cc-2[nH]1.Cl,,O,,O=C([O-])[O-].[K+].[K+],,val
US20080269213A1,CC(=O)Cl.Nc1cccc(C(NC(=O)COc2ccccc2)c2cc(Cl)c3cccnc3c2O)c1>>CC(=O)Nc1cccc(C(NC(=O)COc2ccccc2)c2cc(Cl)c3cccnc3c2O)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120184542A1,CC(C)(C)OC(=O)NCCC(N)c1ccccc1.Cc1ncc2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1>>Cc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CCNC(=O)OC(C)(C)C)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140088078A1,Nc1ccc2c(c1C(=O)O)OCC1CC21.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(O)c1c(NC(=O)C(F)(F)F)ccc2c1OCC1CC21,,C1CCOC1,,CCN(CC)CC,O,val
US20070049560A1,CC(C)(C)NCC(=O)O.Cl.O=S(Cl)Cl>>CC(C)(C)NCC(=O)Cl.Cl,,Cc1ccccc1,,CN(C)C=O,,val
US04185115,CCOC(=O)c1ccc(NCc2ccc(OCc3ccccc3)cc2)cc1>>O=C(O)c1ccc(NCc2ccc(OCc3ccccc3)cc2)cc1,,CCO,O,Cl,[K+].[OH-],val
US05955607,CC1(C)CC(N)c2cc(OCc3ccccc3)ccc2O1.CS(=O)(=O)Cl>>CC1(C)CC(NS(C)(=O)=O)c2cc(OCc3ccccc3)ccc2O1,,C1CCOC1,,CCN(CC)CC,,val
US20030109755A1,CCCCC(O)C1CCCC1=O>>CCCCC=C1CCCC1=O,,Cc1ccccc1,,O=C(O)C(=O)O,,val
US05393755,CN1C(=O)c2c(ncn2Cc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CN1C(=S)c2c(ncn2Cc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12,,Cc1ccccc1C,,,,val
US04513005,CC[C@@](C)(S)[C@H](NC(C)=O)C(=O)O>>CCC1(C)SC(=O)C1NC(C)=O,,ClCCl,,CCN(CC)CC,CCOC(=O)Cl,val
US20070167449A1,OB(O)c1ccsc1.OCCc1cccc(Br)c1>>OCCc1cccc(-c2ccsc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US04044015,BrCc1ccccc1.C1=CC2=NCCN2C=C1>>C1=CCN2CC[NH+](Cc3ccccc3)C2=C1.[Br-],,CCOCC,,CC#N,,val
US20100305145A1,CCOC(=O)c1nnn(Cc2ccc(OC)cc2)n1>>COc1ccc(Cn2nnc(C(=O)O)n2)cc1,,CCO,,[Na+].[OH-],,val
US04736057,CCOC(=O)CC1=C(c2ccccc2)CC(=O)CC1>>CCOC(=O)C[C@@H]1CCC(=O)C[C@@H]1c1ccccc1,[Pd],CCOC(C)=O,,,,val
US06239126B1,COc1ccc(F)cc1C1CCN(C[C@H](N)Cc2cccnc2)CC1.O=C=NC1CCCCC1>>COc1ccc(F)cc1C1CCN(C[C@@H](Cc2cccnc2)NC(=O)NC2CCCCC2)CC1,,ClCCl,,CCN(CC)CC,,val
US20060089367A1,Fc1cc2nc(COc3ccccc3)n(Cc3ccc(OC(F)(F)F)cc3)c2cc1N1CCNCC1.O=C(Cl)C1CC1>>O=C(C1CC1)N1CCN(c2cc3c(cc2F)nc(COc2ccccc2)n3Cc2ccc(OC(F)(F)F)cc2)CC1,,ClCCl,,,,val
US20030166927A1,CCCCC1(CC)CN(c2ccccc2)c2cc(OC)c(OCC(=O)OCC)cc2S(=O)(=O)C1>>CCCCC1(CC)CN(c2ccccc2)c2cc(OC)c(OCC(=O)O)cc2S(=O)(=O)C1,,CCO,O,CC(=O)O,[Na+].[OH-],val
US20150259295A1,COC(=O)C1(c2ccc(-c3ccc(O)cc3)cc2)CC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)C1(c2ccc(-c3ccc(OS(=O)(=O)C(F)(F)F)cc3)cc2)CC1,,O,,ClCCl,,val
US20110059954A1,Cc1cc(C(=O)c2ccnc(Cl)c2)cc2oc(=O)n(C)c12.O=c1[nH]c2ncccc2n1C1CCNCC1>>Cc1cc(C(=O)c2ccnc(N3CCC(n4c(=O)[nH]c5ncccc54)CC3)c2)cc2oc(=O)n(C)c12,,CN1CCCC1=O,CO,,,val
US20120289509A1,CC(=O)c1ccn2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccc(F)cc5)c4=O)cc3F)c12>>Cc1c(C(=O)Nc2ccc(Oc3ccnn4ccc(C(C)O)c34)c(F)c2)c(=O)n(-c2ccc(F)cc2)n1C,,C1CCOC1,CO,[BH4-].[Na+],[Cl-].[NH4+],val
US20150299178A1,COC(=O)C1(Cc2nc(-c3ccc(Cl)cc3)cs2)CCCC1=O>>O=C1CCCC1Cc1nc(-c2ccc(Cl)cc2)cs1,,CC(=O)O,,Cl,,val
US04599348,CC(C)(Cl)C(Cl)=NO.CO>>COC(C)(C)C(Cl)=NO,,CO,,O=C([O-])[O-].[Ca+2],,val
US20160222028A1,CC(=O)Cl.COC(=O)c1ccc2c(c1)OCC(C)(C)NC2>>COC(=O)c1ccc2c(c1)OCC(C)(C)N(C(C)=O)C2,,ClCCl,,CCN(CC)CC,,val
US20080261941A1,CCN(CC)CC.FC(F)(F)c1ccc(Oc2cc(C=C3CCNCC3)cc(C3CC3)c2)nc1.O=C(Nc1cccnc1)Oc1ccccc1>>O=C(Nc1cccnn1)N1CCC(=Cc2cc(Oc3ccc(C(F)(F)F)cn3)cc(C3CC3)c2)CC1,,CS(C)=O,O,,,val
US20040082611A1,Cl.Cn1c(C(=O)N2CCN(S(=O)(=O)c3ccc4cc(Cl)ccc4c3)CC2)cc2c1CCN(C(=O)OC(C)(C)C)C2>>Cl.Cn1c(C(=O)N2CCN(S(=O)(=O)c3ccc4cc(Cl)ccc4c3)CC2)cc2c1CCNC2,,CCO,,,,val
US20030199510A1,CC1CC(=O)c2ccccc21.O=C1Cc2ccccc2N1>>CC1CC(=C2C(=O)Nc3ccccc32)c2ccccc21,,CN(C)C=O,,C1CCNCC1,Cl,val
US20080269193A1,Cc1c[nH]c2c1C(=O)CC(C)(C)C2.N#Cc1c(F)cc(Br)cc1NC1CCC(O)CC1>>Cc1cn(-c2cc(F)c(C#N)c(NC3CCC(O)CC3)c2)c2c1C(=O)CC(C)(C)C2,[Cu]I,C1COCCO1,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US20080009530A1,CCOC(=O)CCc1cc(O)nn1Cc1ccc(Cl)cc1Cl.OCc1ccccc1>>CCOC(=O)CCc1cc(OCc2ccccc2)nn1Cc1ccc(Cl)cc1Cl,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20040204586A1,N#Cc1c(N2CCNCC2)c2cc(Cl)ccc2n(Cc2ccc(F)cc2)c1=O.O=C(Cl)c1cccs1>>N#Cc1c(N2CCN(C(=O)c3cccs3)CC2)c2cc(Cl)ccc2n(Cc2ccc(F)cc2)c1=O,,c1ccncc1,,,,val
US20160159816A1,CCC1(C(=O)O)CCc2c(sc3ncnc(Nc4cc5cn[nH]c5cc4OC)c23)C1.CNC>>CCC1(C(=O)N(C)C)CCc2c(sc3ncnc(Nc4cc5cn[nH]c5cc4OC)c23)C1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070060573A1,COc1ccc(NC(=O)c2ccc(OC)c(F)c2)c(C(=O)C(=O)O)c1.N>>COc1ccc2nc(-c3ccc(OC)c(F)c3)nc(C(=O)O)c2c1,,CCO,,,,val
US20070281955A1,COc1cc(C(=O)CBr)ccc1F.Nc1nccs1>>COc1cc(-c2cn3ccsc3n2)ccc1F,,CCO,,[NH4+].[OH-],,val
US20160251380A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC[C@@H]1C=C2C=COCC3=C2B(OC3)O1>>CC(C)(C)OC(=O)NC[C@@H]1C=C2C=COCC3=C2B(OC3)O1,,ClCCl,,CCN(CC)CC,Cl,val
US20050143372A1,CCC(C(=O)Cl)c1ccccc1.COC(=O)CNC1CCN(Cc2cccc(Oc3ccccc3OC)c2)CC1>>CCC(C(=O)N(CC(=O)OC)C1CCN(Cc2cccc(Oc3ccccc3OC)c2)CC1)c1ccccc1,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20150250169A1,BrCc1ccccc1.CCCNC1=C(O)C(=O)O[C@@H]1[C@@H]1COC(C)(C)O1>>CCCNC1=C(OCc2ccccc2)C(=O)O[C@@H]1[C@@H]1COC(C)(C)O1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04600714,O=S(=O)(O)Cl.c1ccncc1>>O=S(=O)=O.c1ccncc1,,CN(C)C=O,,,,val
US04604390,CCN(CC)CCn1nc2c3c(c([N+](=O)[O-])ccc31)[Se]c1ccc(O)cc1-2.Cl.ClCCCl.ClCCl.O=C1c2ccccc2C(=O)N1CCBr>>CCN(CC)CCn1nc2c3c(c(NCCN)ccc31)[Se]c1ccc(O)cc1-2.Cl.Cl.Cl,[Pd],CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20070249597A1,COc1ccc(CN(Cc2cccc(-c3nn(C)c4[nH]c(=O)c5c(c34)CCCC5)c2)C(=O)OCc2ccccc2)cc1>>Cn1nc(-c2cccc(CN)c2)c2c3c(c(=O)[nH]c21)CCCC3,,O=C(O)C(F)(F)F,,,,val
US20090270361A1,Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1C=O.O=C(OO)c1cccc(Cl)c1>>Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1O,,CC#N,,CCOC(C)=O,,val
US20080004302A1,CC(C)Oc1cc(Nc2ccnc(Cl)n2)[nH]n1.CC(C)c1cc(CN)on1>>CC(C)Oc1cc(Nc2ccnc(NCc3cc(C(C)C)no3)n2)[nH]n1,,COCCO,,CCN(C(C)C)C(C)C,,val
US20120252817A1,Cc1ccc(-c2ccc([C@@H](C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)O)nc2)cn1.Cl.ClCCl>>Cc1ccc(-c2ccc([C@@H](C)NC(=O)[C@@H](N)[C@@H](C)O)nc2)cn1.Cl.Cl.Cl,,ClCCl,,C1COCCO1,,val
US05405839,Cc1cc2nc[nH]c2cc1C.OCCCCCCCl>>Cc1cc2ncn(CCCCCCO)c2cc1C,,CN(C)C=O,,O,[H-].[Na+],val
US20030003245A1,CCCCC[C@@H]1CC[C@@H](C(=O)O)CC1.CCCCC[C@H](F)[C@@H](F)COc1cnc(-c2ccc(OCCCC[Si](C)(C)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc2)nc1>>CCCCC[C@@H]1CC[C@@H](C(=O)Oc2cnc(-c3ccc(OCCCC[Si](C)(C)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc3)nc2)CC1,CN(C)c1ccncc1,CCOC(C)=O,,CC(C)N=C=NC(C)C,,val
US20150274704A1,O=C1CN(Cc2ccccc2)C(=O)C12CCCC2>>OC1CN(Cc2ccccc2)CC12CCCC2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04552585,COC(=O)Nc1ccc(C)c(Cl)c1.O=C1CCC(=O)N1Br>>COC(=O)Nc1ccc(CBr)c(Cl)c1,,ClC(Cl)(Cl)Cl,,,,val
US20120289497A1,Cc1cc(N2CCC[C@@H](N)C2)c2c(n1)n(C)c(=O)n2Cc1ccccc1C#N.N#Cc1ccccc1CBr>>Cc1cc(N2CCC[C@@H](NCc3ccccc3C#N)C2)c2c(n1)n(C)c(=O)n2Cc1ccccc1C#N,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110269738A1,CCOC(=O)CCc1cccc(-c2cnc(-c3ccc(OC(C)C)c(C#N)c3)s2)c1CC>>CCc1c(CCC=O)cccc1-c1cnc(-c2ccc(OC(C)C)c(C#N)c2)s1,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20080020148A1,C=CCBr.CCCCCC1CCC(c2cc(C=O)c(O)c(F)c2F)CC1>>C=CCOc1c(C=O)cc(C2CCC(CCCCC)CC2)c(F)c1F,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160272617A1,Cc1cc(C(=O)NC(C)C)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)O)cc1.Nc1cc(Cl)c2[nH]c(=O)[nH]c2c1>>Cc1cc(C(=O)NC(C)C)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2cc(Cl)c3[nH]c(=O)[nH]c3c2)cc1,,CCOC(C)=O,CS(C)=O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20150336984A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.O=C1NC[C@@H](CO)O1>>CC(C)(C)[Si](OC[C@@H]1CNC(=O)O1)(c1ccccc1)c1ccccc1,CN(C)c1ccncc1,CN(C)C=O,O,c1c[nH]cn1,,val
US20140275026A1,CCS(=O)(=O)c1ccc(F)c(-c2cn(C)c3c(OC)nc(C#CCCO)cc23)c1.Oc1ccc(F)cc1F>>CCS(=O)(=O)c1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c3c(OC)nc(C#CCCO)cc23)c1,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090105124A1,Cn1cnc2nc(-c3ccc(F)cc3)oc(=O)c21.NN>>Cn1cnc(NC(=O)c2ccc(F)cc2)c1C(=O)NN,,C1CCOC1,,,,val
US20070213359A1,ClCCCI.O=C(NCc1cccc(Cl)c1)c1c[nH]c2ccccc12>>O=C(NCc1cccc(Cl)c1)c1cn(CCCCl)c2ccccc12,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110059043A1,COc1ccc(CN2C(=O)C(NC(=O)OC(C)(C)C)N=C(c3c(Cl)cccc3Cl)c3ccccc32)cc1>>COc1ccc(CN2C(=O)C(N)N=C(c3c(Cl)cccc3Cl)c3ccccc32)cc1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US05225607,CCOc1ccc(C(COCc2cccc(Oc3ccccc3)c2)C(F)(F)F)cc1.O=C1CCC(=O)N1Br>>CCOc1ccc(C(COC(Br)c2cccc(Oc3ccccc3)c2)C(F)(F)F)cc1,,ClC(Cl)(Cl)Cl,,,,val
US20110212945A1,O=[N+]([O-])c1cnc(-c2ccccc2)c(-c2ccccc2)c1>>Nc1cnc(-c2ccccc2)c(-c2ccccc2)c1,[Pd],CO,,,,val
US04544654,CCNCCN.CS(=O)(=O)Nc1ccc(C(=O)Cl)cc1>>CCNCCNC(=O)c1ccc(NS(C)(=O)=O)cc1.Cl,,C1CCOC1,,,,val
US04954507,CCN(CC)CC.CCOC(=O)C(Br)CBr.c1ccc(CNCCNCc2ccccc2)cc1>>O=C(O)CCC1CN(Cc2ccccc2)CCN1Cc1ccccc1,,c1ccccc1,,,,val
US20150119412A1,CI.Fc1ncccc1I>>Cc1c(I)ccnc1F,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20060173010A1,CCOC(=O)C(Cl)C(C)=O.Sc1ccc(Cl)cc1>>CCOC(=O)C(Sc1ccc(Cl)cc1)C(C)=O,,COCCOC,,O,O=C([O-])O.[Na+],val
US20030139406A1,COc1ccc(C2CNC(=O)C2)cc1O.OCC=Cc1ccccc1>>COc1ccc(C2CNC(=O)C2)cc1OCC=Cc1ccccc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080311076A1,O=[N+]([O-])c1ccc(N2CCOCC2)cc1C(F)(F)F>>Nc1ccc(N2CCOCC2)cc1C(F)(F)F,[Pd],CCO,,Cc1ccccc1,,val
US20080269200A1,NC(=O)c1cc(Br)cc2cc[nH]c12.OB(O)c1ccccc1F>>NC(=O)c1cc(-c2ccccc2F)cc2cc[nH]c12,,O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20110105506A1,CN.O=C[C@H]([C@@H](O)C1CCCC1)N1C(=O)c2ccccc2C1=O>>CNC[C@H]([C@@H](O)C1CCCC1)N1C(=O)c2ccccc2C1=O,,C1CCOC1,,CC(=O)O,,val
US20110009354A1,CN(CCN)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O.N=C(N)n1cccn1>>CN(CCNC(=N)N)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20060281666A1,COC(=O)c1cc(-c2ccc(OC)cc2)sc1N>>COc1ccc(-c2cc(C(=O)O)c(N)s2)cc1,,CO,,O,[Na+].[OH-],val
US20100197677A1,CC(C)(C)OC(=O)N1Cc2cc3c(cc2CC1C(=O)O)NC(=O)[C@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)O3>>CC(C)(C)OC(=O)N1Cc2cc3c(cc2C[C@H]1C(=O)O)NC(=O)[C@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)O3,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20110086854A1,CC(C)(C)C[C@@H]1N(CC(=O)Nc2ccc(C(=O)O)cc2)C[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F.N>>CC(C)(C)C[C@@H]1N(CC(=O)Nc2ccc(C(N)=O)cc2)C[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120022075A1,CN1CCNCC1.O=S(=O)(Cl)c1ccc(F)cc1>>CN1CCN(S(=O)(=O)c2ccc(F)cc2)CC1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20100204196A1,COc1ccc2c(c1)C[C@H](C)N2C(C)=O.O=N[O-]>>COc1cc2c(cc1[N+](=O)[O-])N(C(C)=O)[C@@H](C)C2,,O=C(O)C(F)(F)F,,O,,val
US20150158858A1,COC(=O)C(N)c1cccc(OCc2ccccc2)c1.O=C(Cl)OCc1ccccc1>>COC(=O)C(NC(=O)OCc1ccccc1)c1cccc(OCc2ccccc2)c1,,C1CCOC1,O,[Na+].[OH-],,val
US20100298593A1,CN.CO/N=C(/C(=O)OC)c1ccccc1COc1ccc(C=C(Cl)Cl)cc1Cl>>CNC(=O)/C(=N/OC)c1ccccc1COc1ccc(C=C(Cl)Cl)cc1Cl,,CO,,,,val
US20120283219A1,CN(C(=O)OC(C)(C)C)c1cccc(OCC(N)=O)c1>>CNc1cccc(OCC(N)=O)c1,,O=C(O)C(F)(F)F,,ClCCl,,val
US04933453,CC1SC(C)(C)C(=O)N1CCCCBr.Cl.Cl.c1ccc(-n2cc(N3CCNCC3)c3ccccc32)cc1>>CC1SC(C)(C)C(=O)N1CCCCN1CCN(c2cn(-c3ccccc3)c3ccccc23)CC1.Cl.Cl,,CC#N,,CCN(C(C)C)C(C)C,[I-].[Na+],val
US06235911B1,CCOC(=O)C(F)(F)F.CCOC(=O)CC#N.[Na]>>CCOC(=O)C(C#N)=C(O)C(F)(F)F.[Na],,CCO,,,,val
US20160016914A1,COC(=O)C1CC2(C1)CC(c1n[nH]c(=O)c3ccccc13)C2>>O=c1[nH]nc(C2CC3(CC(CO)C3)C2)c2ccccc12,,C1CCOC1,,[BH4-].[Li+],,val
US06127570,CC(=O)OC(C)=O.Cc1c(Br)ccc(O)c1C(=O)O>>CC(=O)Oc1ccc(Br)c(C)c1C(=O)O,,CCOC(C)=O,O,Cl,c1ccncc1,val
US20140336224A1,CCC(C#N)(c1ccc(Cl)cc1)c1n[nH]c2c(N)cccc12.CS(=O)(=O)Cl>>CCC(C#N)(c1ccc(Cl)cc1)c1n[nH]c2c(NS(C)(=O)=O)cccc12,,ClCCl,,CN1CCOCC1,,val
US20150051171A1,Cc1c(Cl)cccc1C(=O)O.O=C(Cl)C(=O)Cl>>Cc1c(Cl)cccc1C(=O)Cl,,C1CCOC1,,CN(C)C=O,,val
US06593325B1,Clc1nnc(-c2ccccc2)c2nc(OCc3ccccc3)ccc12>>O=c1ccc2cnnc(-c3ccccc3)c2[nH]1,[Pd],CC(C)O,,O=C[O-].[NH4+],,val
US20110288052A1,CCCCCCCCC1(C)SC(=O)C=C1OCC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.FC(F)(F)c1ccc(I)cc1>>CCCCCCCCC1(C)SC(=O)C=C1OCC(=O)Nc1ccc(-c2ccc(C(F)(F)F)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160102071A1,CC#C[C@@H](CC(=O)OCC)c1ccc(OCc2ccc3scc(-c4ccc(OCC5COC(C)(C)O5)cc4C)c3c2)cc1>>CC#C[C@@H](CC(=O)OCC)c1ccc(OCc2ccc3scc(-c4ccc(OCC(O)CO)cc4C)c3c2)cc1,,C1CCOC1,,Cl,O,val
US04738710,CCOC(=O)C(C)Oc1ccc(Oc2cnc3cc(Cl)ccc3c2)cc1.N>>CC(Oc1ccc(Oc2cnc3cc(Cl)ccc3c2)cc1)C(N)=O,,CC(C)=O,,,,val
US20050148602A1,O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C1N(c2cc(Cl)nc(Cl)c2)C(=O)[C@@]2(Cc3ccc(OC(F)(F)F)cc3)C[C@H](n3cccc3)CN12>>O=C1N(c2cc(Cl)nc(Cl)c2)C(=O)[C@]2(Cc3ccc(OC(F)(F)F)cc3)C[C@@H](c3cc[nH]c3C(=O)C(F)(F)F)CN12,,ClCCl,,,,val
US20140194432A1,CCOC(=O)c1cn(Cc2ccccc2-c2ccccc2)c2cccnc2c1=O>>O=C(O)c1cn(Cc2ccccc2-c2ccccc2)c2cccnc2c1=O,,CO,O,Cl,[Li]O,val
US20130131040A1,N#Cc1ncc(N[C@@H]2CCCC(F)(F)[C@@H]2N)nc1Nc1ccc(-c2ccno2)cc1.OO>>NC(=O)c1ncc(N[C@@H]2CCCC(F)(F)[C@@H]2N)nc1Nc1ccc(-c2ccno2)cc1,,CCO,CS(C)=O,CC(=O)O,[Na+].[OH-],val
US20050171350A1,CC(C)C[Mg]Br.Clc1cc(Cl)nc(Cl)n1>>CC(C)Cc1cc(Cl)nc(Cl)n1,,C1CCOC1,CCOCC,,,val
US06162808,COC(=O)C[C@H](NC(=O)Cc1csc(N)n1)C(=O)OC.Cc1ccc2c(c1)C=Cc1cc(C)ccc1C2c1cn(Cc2ccc(C(=O)O)o2)c(=O)[nH]c1=S>>COC(=O)C[C@H](NC(=O)Cc1csc(NC(=O)c2ccc(Cn3cc(C4c5ccc(C)cc5C=Cc5cc(C)ccc54)c(=S)[nH]c3=O)o2)n1)C(=O)OC,CN(C)c1ccncc1,CN(C)C=O,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20090099173A1,C[C@@H]1CNCCN1c1nnc(-c2ccc(C(F)(F)F)cc2)c2ccncc12.O=C(Cl)c1ccccc1>>C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(C(F)(F)F)cc2)c2ccncc12,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4nccs4)nc(Cl)c3n2)cc1.COc1ccc(N)cc1OC>>COc1ccc(Nc2nc(-c3nccs3)nc3cn[nH]c23)cc1OC,C1COCCO1,CO,,Cl,,val
US04845291,C=CC(=C)C.Cc1ccc(N)cc1N>>CC(C)=CCc1cc(C)c(N)cc1N,,CCCCC,,,,val
US20140228343A1,BrCC1CO1.Oc1cccc(Br)c1>>Brc1cccc(OCC2CO2)c1,,CN(C)C=O,,O,[H-].[Na+],val
US20160206748A1,CC1(C)OC2CC(C)(C(=O)NCCCNC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@@H]43)CC2O1>>CC1(C(=O)NCCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@@H]32)CC(O)C(O)C1,CO,,,Cl,,val
US20070219198A1,COc1cccc(S(=O)(=O)Cl)c1.C[C@@H]1CN(c2ccc(F)cc2C(F)(F)F)CCN1>>COc1cccc(S(=O)(=O)N2CCN(c3ccc(F)cc3C(F)(F)F)C[C@H]2C)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04886625,N#Cc1cc(-c2cccs2)[nH]c1-c1cccs1>>N#Cc1c(-c2cccs2)c[nH]c1-c1cccs1,,C1CCOC1,,,,val
US03959309,CN(C)CCCl.O=C(OC1CCc2[nH]c3ccccc3c2C1)c1ccccc1>>CN(C)CCn1c2c(c3ccccc31)CC(OC(=O)c1ccccc1)CC2,,c1ccccc1,,CN(C)C=O,[H-].[Na+],val
US20120149691A1,CCOC(=O)c1cccn1N.CCOC(CC#N)OCC>>N#Cc1cnn2cccc2c1O,,CCO,CCOC(C)=O,C1CCC2=NCCCN2CC1,Cl,val
US20100298302A1,N#Cc1ccc(-n2cccc2)c(N)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>N#Cc1ccc2c(c1)[nH]c(=O)c1cccn12,,Cc1ccccc1,,,,val
US20140018313A1,COC(=O)Cl.COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3cc(-c4ccc(-c5cnc([C@@H]6CCCN6C(=O)[C@@H](N)C6CCSCC6)[nH]5)cc4)ccc3c2)[nH]1)C(C)C>>COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3cc(-c4ccc(-c5cnc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)C6CCSCC6)[nH]5)cc4)ccc3c2)[nH]1)C(C)C,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US05852014,CCOC(=O)Cc1ccccc1N.O=C(Cl)CCCCCl>>CCOC(=O)Cc1ccccc1NC(=O)CCCCCl,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US06544985B2,Cc1noc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)c(N(C)C)cc3NC(=O)OC(C)(C)C)c2)c1COC1CCCCO1>>Cc1noc(-c2cccc(C3=Nc4cc(N(C)C)c(C(F)(F)F)cc4NC(=O)C3)c2)c1CO,,ClCCl,,O=C(O)C(F)(F)F,,val
US07713994B2,CON.O=Cc1ccc(OCCN2CCCC2)c(O)c1>>CON=Cc1ccc(OCCN2CCCC2)c(O)c1,,O,,Cl,c1ccncc1,val
US04695569,Fc1ccc(Cn2c(NC3CCN(CCN=C=S)CC3)nc3ccccc32)cc1.N>>NC(=S)NCCN1CCC(Nc2nc3ccccc3n2Cc2ccc(F)cc2)CC1,,CO,,,,val
US20080090863A1,Cc1cnc(N[C@@H]2CC[C@H](N)CC2)cc1N(C)C.ClC(Cl)Cl.O=Cc1ccc(F)c(Cl)c1>>Cc1cnc(N[C@@H]2CC[C@H](NCc3ccc(F)c(Cl)c3)CC2)cc1N(C)C.Cl.Cl,,CC(=O)O,ClC(Cl)Cl,O=C([O-])O.[Na+],,val
US20130065905A1,COS(=O)(=O)c1ccc(C)cc1.Cc1ncc(C=O)[nH]1>>Cc1ncc(C=O)n1C,,CN(C)C=O,O,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US06531613B1,CC(C)CC(O)CC(C)C.CS(=O)(=O)Cl>>CC(C)CC(CC(C)C)OS(C)(=O)=O,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20090197877A1,CCCC[Sn](CCCC)(CCCC)c1cccn1C.CCNC(=O)Nc1nc2cc(-c3cccnc3)cc(I)c2s1>>CCNC(=O)Nc1nc2cc(-c3cccnc3)cc(-c3cccn3C)c2s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US04482546,CCOc1c(C)cc(N)cc1CC.O=C(Cl)Cl>>CCOc1c(C)cc(N=C=O)cc1CC,,Cc1ccccc1,,,,val
US20080108608A1,NCCN1CCCC1.Nc1cccc(C#Cc2cnc(Cl)nc2)c1>>Nc1cccc(C#Cc2cnc(NCCN3CCCC3)nc2)c1,,CC#N,,Cl,,val
US06150524,CC(=O)O.COCOc1ccc2c3c1O[C@H]1[C@@H](OCC4CCCCO4)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341>>CC(=O)Oc1ccc2c3c1O[C@H]1[C@@H](OCC4CCCCO4)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341,,O,,,,val
US20110092479A1,Brc1n[nH]c2ncccc12.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)n2nc(Br)c3cccnc32)cc1,,C1CCOC1,,[H-].[Na+],,val
US20080255094A1,CC(C)(C)OC(=O)N1CCS[C@H]1C(=O)N[C@H](c1ccccc1)c1ccccn1.Cl>>Cl.O=C(N[C@H](c1ccccc1)c1ccccn1)[C@H]1NCCS1,,ClCCl,,[Na+].[OH-],,val
US20010056105A1,Cc1cc2c(cc1[Se]C#Cc1ccc(C(=O)O)cn1)C(C)(C)CCC2(C)C.Nc1ccc(O)cc1>>Cc1cc2c(cc1[Se]C#Cc1ccc(C(=O)Nc3ccc(O)cc3)cn1)C(C)(C)CCC2(C)C,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20120232117A1,CCOC(=O)CC(=O)Cc1ccccc1.NNc1ccccn1>>Oc1cc(Cc2ccccc2)nn1-c1ccccn1,,CCO,,,,val
US20110009381A1,COC(=O)c1cc(Cl)nc(Cl)n1.COCCN1CCNCC1>>COCCN1CCN(c2cc(C(=O)OC)nc(Cl)n2)CC1,,ClCCl,O,CCN(CC)CC,,val
US20060106048A1,CCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccc(C(=O)OC)c(N)c1)=NC(C)(C)C2.Cl>>CCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccc(C(=O)OC)c(N)c1)=NC(C)(C)C2.Cl,,CCOC(C)=O,,,,val
US06258953B1,NCc1ccc(Cl)cc1.O=C(Cl)Cc1ccccc1>>O=C(Cc1ccccc1)NCc1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20030114404A1,Cc1ccc(S(=O)(=O)OCCOCCOCCOCCO)cc1.O=C1NC(=O)c2ccccc21>>O=C1NC(=O)c2ccccc21.OCCOCCOCCOCCO,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US20080085887A1,Cc1ncccc1C(F)F.O=[Se]>>O=Cc1ncccc1C(F)F,,C1COCCO1,,,,val
US06380387B1,ClI.O=c1cc[nH]c(=O)[nH]1>>O=c1[nH]cc(I)c(=O)[nH]1,,CO,,,,val
US05086065,CCOC(=O)CCCCBr.O=c1ccc2cc(O)ccc2o1>>CCOC(=O)CCCCOc1ccc2oc(=O)ccc2c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US04076729,COc1ccc2c(O)c([N+](=O)[O-])c(=O)oc2c1>>COc1ccc(C(=O)C[N+](=O)[O-])c(O)c1,,[Na+],[OH-],Cl,,val
US20140128368A1,CC(C)c1noc(N2CCC([C@H]3C[C@H]3CO)CC2)n1.Fc1cc(Br)ccc1CBr>>CC(C)c1noc(N2CCC([C@H]3C[C@H]3COCc3ccc(Br)cc3F)CC2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20120122840A1,COc1cc(C2CCNCC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1.O=S(=O)(CCCCl)N1CCOCC1>>COc1cc(C2CCN(CCCS(=O)(=O)N3CCOCC3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20090137557A1,CC(=O)Oc1c(F)cccc1C(=O)Cl.NC1=C(C(=O)NCCc2cccc(F)c2)CCCC1.c1ccncc1>>CC(=O)Oc1c(F)cccc1C(=O)CNC1=C(C(=O)NCCc2cccc(F)c2)CCCC1,,C1CCOC1,c1ccncc1,CCOCC,,val
US05041679,COc1ccccc1SCCC(O)CC(C)=O>>COc1ccccc1SCCC=CC(C)=O,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04999378,COC(=O)C(C)=Cc1ccc(OCCCCl)cc1.Nc1ccc(Cl)cc1>>COC(=O)C(C)=Cc1ccc(OCCCNc2ccc(Cl)cc2)cc1,,O,,CN(C)C=O,O=C([O-])O.[Na+],val
US20060122195A1,COC(=O)[C@H](CS)NC(=O)OC(C)(C)C.COc1nc(Cl)cnc1N(COCC[Si](C)(C)C)S(=O)(=O)c1cccc(Cl)c1Cl>>COC(=O)[C@H](CSc1cnc(N(COCC[Si](C)(C)C)S(=O)(=O)c2cccc(Cl)c2Cl)c(OC)n1)NC(=O)OC(C)(C)C,,CC#N,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05116844,C1CCOC1.CC(C(=O)c1ccc(F)cc1F)c1cccnc1>>CC(c1cccnc1)C1(c2ccc(F)cc2F)CO1,,O,,,,val
US20070179151A1,Cc1cc(N)n[nH]1.N#CCc1ccc(Br)cc1C(=O)O>>Cc1cc(Nc2cc3ccc(Br)cc3c(O)n2)n[nH]1,,CC(=O)O,,,,val
US20150322056A1,C=C(C)CN(Cc1ccc(OC)cc1)C(=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C(=O)O.CO>>C=C(C)CN(Cc1ccc(OC)cc1)C(=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C(=O)OC,,CO,ClCCl,C[Si](C)(C)C=[N+]=[N-],,val
US20120252780A1,CC1(C)OC[C@H](COc2cccc(NC(=O)N3CCOc4ccc(-c5cccc(C(F)(F)F)c5)nc43)n2)O1>>O=C(Nc1cccc(OC[C@H](O)CO)n1)N1CCOc2ccc(-c3cccc(C(F)(F)F)c3)nc21,Cl,CO,,,,val
US20070105845A1,Cc1ccc(Br)cc1.O=C1CCc2ccccc2N1>>Cc1ccc(N2C(=O)CCc3ccccc32)cc1,[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=C([O-])[O-].[K+].[K+],val
US05578242,CCCCSc1ccc2cc(C(=O)O)ccc2c1.S=C=Nc1ccc(S)cc1>>CCCCSc1ccc2cc(C(=O)Sc3ccc(N=C=S)cc3)ccc2c1,CN(C)c1ccncc1,,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060235024A1,CC(C)COC(=O)Cl.CCC(C#Cc1cccc(Cl)c1)N1CCNCC1>>CCC(C#Cc1cccc(Cl)c1)N1CCN(C(=O)OCC(C)C)CC1,,ClCCl,,CCN(CC)CC,,val
US20140178360A1,COc1cnc(-c2ccc(NC(=S)Nc3ccccc3N)cc2)nc1N1CCOCC1>>COc1cnc(-c2ccc(Nc3nc4ccccc4[nH]3)cc2)nc1N1CCOCC1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20020127605A1,Nc1cccc(C2OCCO2)c1.O=C(Cl)CCCCc1ccccc1>>O=C(CCCCc1ccccc1)Nc1cccc(C2OCCO2)c1,,C1CCOC1,,CCN(CC)CC,,val
US20080081029A1,C=C(C)C(=O)NCCCCCCCCCCC(=O)O.C=C(C)C(=O)OCC(F)(F)C(F)F>>C=C(C)C(=O)NCCCCCCCCCCC(=O)O.C=C(C)C(=O)OCC(F)(F)C(F)F,CC(C)(C#N)N=NC(C)(C)C#N,CO,,CCOCC,,val
US20140031355A1,CC(=O)c1cnc2c(Cl)cc(F)cc2c1Cl.CCCC[Sn](CCCC)(CCCC)c1ccccn1>>CC(=O)c1cnc2c(Cl)cc(F)cc2c1-c1ccccn1,,C1COCCO1,,,,val
US20020099030A1,CC(C)(C)OC(=O)N1CC[C@H](NC(=O)C(F)(F)F)C1>>O=C(N[C@H]1CCNC1)C(F)(F)F,,O=C(O)C(F)(F)F,,,,val
US20110263558A1,CC([N+](=O)[O-])C1(O)CN(C(=O)c2cn3ccnc3c(Cl)c2Nc2ccc(I)cc2F)C1>>CC(N)C1(O)CN(C(=O)c2cn3ccnc3c(Cl)c2Nc2ccc(I)cc2F)C1,[Fe],C1CCOC1,O,O=C[O-].[NH4+],,val
US05462952,CCOC(OCC)OCC.Cc1ccc(Cl)c(Nc2ccccc2C(=O)NN)c1Cl>>Cc1ccc(Cl)c(Nc2ccccc2-c2nnco2)c1Cl,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110118245A1,CC(CF)(CF)c1cc(NC(=O)Oc2ccccc2)on1.COc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC>>COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(CF)CF)no4)c3)c2cc1OC,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US05495036,CCC(C)(C)O[K].c1ccc(Cc2ccccc2)cc1>>[K]C(c1ccccc1)c1ccccc1,,CCCCCC,,[Li]CCCC,,val
US20100137278A1,CC(=O)N1CCC(c2nccnc2F)CC1.O=C(c1ccc(O)cc1)c1nc2ccccc2[nH]1>>CC(=O)N1CCC(c2nccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04241074,CC(=O)CCCCC=CCO.CS(=O)(=O)Cl>>CC(=O)CCCCC=CCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20030166644A1,CN1CCNCC1.O=C(Cl)Oc1ccc(Cl)cc1>>CN1CCN(C(=O)Oc2ccc(Cl)cc2)CC1,,O,,[Br-].[K+],,val
US04454320,Clc1sccc1Br.O=C1NC(=O)C(=O)C(=O)N1>>O=C1NC(=O)C(c2ccsc2Cl)C(=O)N1,,C1CCOC1,CCOCC,[Li]CCCC,,val
US04136192,CC#N.COC(=O)c1ccc(OCCCOc2ccccc2)cc1C(=O)OC>>N#CC1C(=O)c2ccc(OCCCOc3ccccc3)cc2C1=O,,CCOCC,,[H-].[Na+],,val
US20120309755A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1cc(F)c(Cl)c(N)c1Cl>>CC(C)(C)OC(=O)NCc1cc(F)c(Cl)c(N)c1Cl,,C1CCOC1,,,,val
US20110144153A1,COC(=O)c1ccc(C=O)c(OC)c1.C[Mg]Br>>COC(=O)c1ccc(C(C)O)c(OC)c1,,C1CCOC1,,[Cl-].[NH4+],,val
US05116862,C#CCCCCOS(C)(=O)=O.CCOC(=O)CC(=O)OCC>>C#CCCCCC(C(=O)O)C(=O)O,,CCO,,O,[Na],val
US20120046280A1,CCC(=O)Cl.Ic1ccccc1>>CCC(=O)c1ccc(I)cc1,,S=C=S,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20100331320A1,C=CCC(O)(CCN[C@@H](C)c1ccc(Br)cc1)C(C)C.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C=CCC1(C(C)C)CCN([C@@H](C)c2ccc(Br)cc2)C(=O)O1,,ClCCl,,CCN(CC)CC,,val
US20150291549A1,CS(=O)(=O)c1cccc(CO)c1.O=S(Cl)Cl>>CS(=O)(=O)c1cccc(CCl)c1,,ClCCl,,,,val
US20110112103A1,CCOC(=O)CC#N.O=C1CCN(c2ccc(F)cc2)CC1>>CCOC(=O)C(C#N)=C1CCN(c2ccc(F)cc2)CC1,,Cc1ccccc1,,C,O=C[O-].[NH4+],val
US20120010235A1,CC1(C)OC[C@H](CCNC(=O)C2C(c3cccc(Cl)c3F)C(C#N)(c3ccc(Cl)cc3F)C3CC(C)(C)C(=O)N23)O1>>CC1(C)CC2N(C1=O)C(C(=O)NCC[C@H](O)CO)C(c1cccc(Cl)c1F)C2(C#N)c1ccc(Cl)cc1F,,C1CCOC1,,Cl,,val
US20040198836A1,COc1ccc(OC)c(C(=O)CNC(=O)CN=[N+]=[N-])c1>>COc1ccc(OC)c(C(O)CNC(=O)CN=[N+]=[N-])c1,,CO,,CC(=O)O,[BH4-].[Na+],val
US20130281490A1,C1CCOC1.CC(C)[C@@H](O)[C@H](N)C(=O)O.Cc1c(-c2ccc(-c3ccccc3)cc2)ccn(C(=O)[O-])c1=O.Cc1c(-c2ccc(-c3ccccc3)cc2)ccnc1OC(=O)[O-]>>COC(=O)N(c1ccc(-c2ccccc2)cc1)[C@H](C(=O)O)[C@H](O)C(C)C,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20050261294A1,COC(=O)c1cccc(CN(c2nccc(-c3ccc(O)cc3)n2)C2CCCC2)c1.C[C@@H]1CC[C@H](O)CC1>>COC(=O)c1cccc(CN(c2nccc(-c3ccc(O[C@@H]4CC[C@@H](C)CC4)cc3)n2)C2CCCC2)c1,,C1CCOC1,O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030194722A1,CC(=O)Oc1c(F)c(F)c(F)c(F)c1F.NC[C@]1(CO)O[C@@H](n2ccc(=O)[nH]c2=O)C[C@@H]1O>>CC(=O)NC[C@]1(CO)O[C@@H](n2ccc(=O)[nH]c2=O)C[C@@H]1O,,CN(C)C=O,,,,val
US04190662,COc1cc(C(Cl)(Cl)Cl)cc(OC)n1>>COc1cc(C(Cl)Cl)cc(OC)n1,,CC(C)=O,,Cl,,val
US20100125082A1,C[Sn](C)(C)[Sn](C)(C)C.N#Cc1ccnc(Br)c1>>C[Sn](C)(C)c1cc(C#N)ccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US04874764,Cc1c(N2CCN(Cc3ccccc3)C(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12>>Cc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,[Pd],CC(=O)O,,,,val
US20040266864A1,CNCCC[C@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>CNCCC[C@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-],,CO,O,,,val
US06281353B1,CN1Cc2c(-c3noc(CCl)n3)ncn2-c2cccc(Cl)c2C1=O.CNC>>CN(C)Cc1nc(-c2ncn3c2CN(C)C(=O)c2c(Cl)cccc2-3)no1,,C1COCCO1,,,,val
US20090069320A1,BrBr.COc1ccc(C(=O)O)c(N)c1>>COc1cc(N)c(C(=O)O)cc1Br,,CC(=O)O,,,,val
US20110076276A1,COc1nc(Cl)c(C(C)C)c(OC)n1.OCc1ccccc1>>COc1nc(O)c(C(C)C)c(OC)n1,,CN(C)C=O,,[H-].[Na+],,val
US20090099182A1,CC(C)(C)[Si](OC1CCC(C2CCN(Cc3c(Cl)cc(O)cc3Cl)C2=O)CC1)(c1ccccc1)c1ccccc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)[Si](OC1CCC(C2CCN(Cc3c(Cl)cc(OS(=O)(=O)C(F)(F)F)cc3Cl)C2=O)CC1)(c1ccccc1)c1ccccc1,,ClCCl,,c1ccncc1,,val
US04700008,CC1=CCC2CC1C(O)CC2C.CI>>COC1CC(C)C2CC=C(C)C1C2,,C1CCOC1,,[Na],,val
US20130158009A1,O=C(O)c1ccc(O[C@H]2CCN(C3CCN(c4ncc(Cl)cc4F)CC3)C2=O)c(F)c1.O[C@H]1CCNC1>>O=C(c1ccc(O[C@H]2CCN(C3CCN(c4ncc(Cl)cc4F)CC3)C2=O)c(F)c1)N1CC[C@H](O)C1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130116232A1,C1=COCCC1.Cc1ccc(S(=O)(=O)[O-])cc1.O=C(Cc1cccc(O)c1)c1cc(O)ccc1O.c1cc[nH+]cc1>>O=C(Cc1cccc(OC2CCCCO2)c1)c1cc(OC2CCCCO2)ccc1O,,ClCCl,,,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)O)c2)=C(C)C1=O.Nc1cccnc1>>COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3cccnc3)c2)=C(C)C1=O,,ClCCl,,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US20030008849A1,CC#CCOc1ccc(S(=O)(=O)NCC(=O)OCC)cc1>>CC#CCOc1ccc(S(=O)(=O)NCC(=O)O)cc1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20030162764A1,CC(=O)NCCNc1cc(NCCN)nc(-c2ccc(Cl)cc2)n1.O=C(O)c1ccc2ccccc2n1>>CC(=O)NCCNc1cc(NCCNC(=O)c2ccc3ccccc3n2)nc(-c2ccc(Cl)cc2)n1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05356886,CC(C)OP(=O)(/C=C/CCO)OC(C)C.O=C1c2ccccc2C(=O)N1c1ncnc2c1ncn2O>>CC(C)OP(=O)(/C=C/CCOn1cnc2c(N3C(=O)c4ccccc4C3=O)ncnc21)OC(C)C,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070197588A1,BrC(Br)(Br)Br.OCC1Cc2ccccc2C(c2ccc(Cl)c(Cl)c2)C1>>Clc1ccc(C2CC(CBr)Cc3ccccc32)cc1Cl,,ClCCl,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130217698A1,OCC#Cc1cnc(Cl)nc1NC1CCCC1>>OCc1cc2cnc(Cl)nc2n1C1CCCC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050239841A1,COc1ccc([C@@]23CCC(N)C[C@@H]2N(Cc2ccccc2)CC3)cc1OC.O=C=Nc1ccc(F)c(F)c1>>COc1ccc([C@@]23CC[C@@H](NC(=O)Nc4ccc(F)c(F)c4)C[C@@H]2N(Cc2ccccc2)CC3)cc1OC,,ClCCl,,,,val
US06248739B1,CCOC=C(C(=O)OCC)C(=O)OCC.Nc1ccccc1I>>CCOC(=O)c1cnc2c(I)cccc2c1O,,c1ccc(Oc2ccccc2)cc1,,,,val
US20060052408A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC[C@]1(c2ccccc2)C[C@H]1COCc1ccccc1>>CC(C)(C)OC(=O)NC[C@]1(c2ccccc2)C[C@H]1COCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US05932595,CC(C)(C)ONC(=O)CC1(Sc2ccc(Oc3ccccc3)cc2)CCCC1>>O=C(CC1(Sc2ccc(Oc3ccccc3)cc2)CCCC1)NO,,O=C(O)C(F)(F)F,,,,val
US20140080816A1,COC(=O)C1CCCN1.O=[N+]([O-])c1cccc(F)c1F>>COC(=O)C1CCCN1c1c(F)cccc1[N+](=O)[O-],,CC#N,,CCN(CC)CC,,val
US04650811,OCCCCl.Oc1ccccc1C=Cc1cccc2[nH]ccc12>>ClCCCOc1ccccc1C=Cc1cccc2[nH]ccc12,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120202853A1,CCc1nn(-c2ccc(O)cc2)c(N(CC)CC)c1C#N.NO>>CCc1nn(-c2ccc(O)cc2)c(N(CC)CC)c1/C(N)=N/O,,CS(C)=O,,,,val
US20090163380A1,C=CCCCCCCCCCOCCOCCOCCOc1ccc(OCC(=O)OC(C)(C)C)cc1.CC(O)=S>>CC(=O)SCCCCCCCCCCCOCCOCCOCCOc1ccc(OCC(=O)OC(C)(C)C)cc1,CC(C)(C#N)N=NC(C)(C)C#N,CO,,,,val
US20070254925A1,O=C(Nc1nc(CO)c(-c2cccc(C(F)(F)F)c2)s1)c1c(F)cccc1F.O=S(Cl)Cl>>O=C(Nc1nc(CCl)c(-c2cccc(C(F)(F)F)c2)s1)c1c(F)cccc1F,,ClCCl,,CCN(CC)CC,O,val
US20090105210A1,Cc1cc(C)c(C=C(C#N)C#N)c(C)c1.Nc1n[nH]c2c1CSC2>>Cc1cc(C)c(-c2nc3c4c(nn3c(N)c2C#N)CSC4)c(C)c1,,c1ccncc1,,,,val
US20030069297A1,COc1cccc(-c2cccc3c2CC(=O)N3)c1.Cc1[nH]c(C=O)c(C)c1C(=O)NCCn1ccnn1>>COc1cccc(-c2cccc3c2C(=Cc2[nH]c(C)c(C(=O)NCCn4ccnn4)c2C)C(=O)N3)c1,C1CCNCC1,CCO,,,,val
US20160190470A1,CC1(C)c2ccccc2-c2ccc(B(O)O)cc21.O=[N+]([O-])c1ccc(Br)c(-c2ccccc2)c1>>CC1(C)c2ccccc2-c2ccc(-c3ccc([N+](=O)[O-])cc3-c3ccccc3)cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US04940710,CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)cc21.O=S(=O)(c1ccccc1)n1cc(C2CNCCN2)c2ccccc21>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(c4cn(S(=O)(=O)c5ccccc5)c5ccccc45)C3)cc21,,c1ccncc1,,,,val
US20100075948A1,COc1cc(Cl)ccc1C1(C#N)C(CC(C)(C)C)NC(C(=O)OC(C)(C)C)C1c1cccc(Cl)c1F.O=C(O)C(F)(F)F>>COc1cc(Cl)ccc1C1(C#N)C(CC(C)(C)C)NC(C(=O)O)C1c1cccc(Cl)c1F.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05925632,CC(C)CN1CCC(Br)C1=O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)CN1CCC([P+](c2ccccc2)(c2ccccc2)c2ccccc2)C1=O.[Br-],,C1CCOC1,,,,val
US05705621,CC(=O)OCC=C[Si](c1ccccc1)(c1ccccc1)c1ccccc1>>OCC=C[Si](c1ccccc1)(c1ccccc1)c1ccccc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US05410043,C1CNCCNCCCNCCNC1.CO.COC(OC)N(C)C.Cc1ccccc1>>N#CCCN1CCCNCCNCCCNCC1,,O,,[Na+].[OH-],,val
US04640916,CCOC(=O)C1Sc2ccccc2NC1=O>>O=C1Nc2ccccc2SC1CO,,CCO,O,CC(=O)O,[BH4-].[Na+],val
US20090203657A1,Fc1ccccc1Br.O=C=O>>O=C(O)c1cccc(Br)c1F,,C1CCOC1,CCCCCC,CC1(C)CCCC(C)(C)N1,[Li]CCCC,val
US20080085890A1,CC1(C)Oc2cc(CO)cc(OCc3ccccc3)c2O1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC1(C)Oc2cc(CN=[N+]=[N-])cc(OCc3ccccc3)c2O1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20070191604A1,CN(C=O)C1(C(=O)Nc2ccc3c(c2)c(-c2ccc(F)cc2)nn3C(c2ccccc2)(c2ccccc2)c2ccccc2)CCN(CC(=O)N2CC=C(c3ccc(-c4ncccn4)cc3)CC2)C1>>CN(C=O)C1(C(=O)Nc2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)CCN(CC(=O)N2CC=C(c3ccc(-c4ncccn4)cc3)CC2)C1,,ClCCl,,C1COCCO1,Cl,val
US20140275011A1,Nc1ccc(Br)cc1NCc1cccc(F)c1.O=CO>>Fc1cccc(Cn2cnc3ccc(Br)cc32)c1,,CCOC(C)=O,,,,val
US20060004013A1,CI.O=C(/C=C/c1ccc(-n2ccnc2)c(F)c1)NC1CCc2ccccc21>>CN(C(=O)/C=C/c1ccc(-n2ccnc2)c(F)c1)C1CCc2ccccc21,,CCOC(C)=O,O,CN(C)C=O,[H-].[Na+],val
US20120214769A1,COC(=O)c1ccc(CC(C(=O)N2C(=O)OC[C@H]2Cc2ccccc2)c2ccc(C=CC(C)(C)C)cc2)cc1.OO>>COC(=O)c1ccc(C[C@@H](C(=O)O)c2ccc(C=CC(C)(C)C)cc2)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20130109708A1,CC(C)COc1ncc(O)cc1Cl.COC(=O)c1ccc(CBr)cc1>>COC(=O)c1ccc(COc2cnc(OCC(C)C)c(Cl)c2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130065893A1,N#Cc1ccc([C@H]2CC(O)(c3cccc(OC4CCCCO4)c3)c3cncn32)c(F)c1>>N#Cc1ccc([C@H]2C[C@](O)(c3cccc(O)c3)c3cncn32)c(F)c1,,CO,,CCOCC,Cl,val
US20130121994A1,CCOc1cc(C(=O)O)ccc1Br.CN(C)C=O>>CCOc1cc(C(=O)NCCO)ccc1Br,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US04126689,CC(C)N1CCC(=Nc2ccccc2)CC1>>CC(C)N1CCC(Nc2ccccc2)CC1,,CO,,[BH4-].[Na+],,val
US20070161673A1,CCCS(=O)(=O)Cl.Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(N)n[nH]c2n1>>CCCS(=O)(=O)Nc1n[nH]c2nc(-c3cc(C(=O)NC4CC4)ccc3C)ccc12,,c1ccncc1,,,,val
US20110002855A1,O=C(CCl)N1CCN(C2CCC2)CC1.c1ccn2nc3c(c2c1)CNCC3>>O=C(CN1CCc2nn3ccccc3c2C1)N1CCN(C2CCC2)CC1,,CC#N,O,[I-].[K+],O=C([O-])O.[Na+],val
US20090286765A1,C1COCCN1.COC(=O)[C@H](CO)NC(=O)OC(C)(C)C>>COC(=O)[C@H](CN1CCOCC1)NC(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US05707994,COC(=O)CCCCCc1ccc(C#N)cc1.O>>COC(=O)CCCCC(=O)c1ccc(C#N)cc1,,CCOC(C)=O,O,CC(=O)O,,val
US20150080362A1,CCc1c(OCOC)c(C(=O)OC)c(=O)n(Cc2ccc(OC)cc2OC)c1-c1ccc(C2=CCN(C(=O)OC(C)(C)C)CC2)cc1>>CCc1c(O)c(C(=O)OC)c(=O)n(Cc2ccc(OC)cc2OC)c1-c1ccc(C2CCN(C(=O)OC(C)(C)C)CC2)cc1,[Pd],CCOC(C)=O,CO,,,val
US04525473,CO/N=C(\C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CI)CS[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1.O=C(OO)c1cccc(Cl)c1>>CO/N=C(\C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CI)CS(=O)[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,ClCCl,,O,,val
US20070270422A1,C1CSCCN1.Cl.O=C(Nc1ccc(Oc2ccc(CCl)cc2)nc1)c1ccc(Cl)c(Cl)c1>>Cl.O=C(Nc1ccc(Oc2ccc(CN3CCSCC3)cc2)nc1)c1ccc(Cl)c(Cl)c1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20070185168A1,OC1(c2cccs2)CCNCC1>>c1csc(C2CCNCC2)c1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20070191289A1,CC(C)(C)C(=O)OC[C@H]1O[C@H](Br)[C@H](OC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@@H]1OC(=O)C(C)(C)C.Oc1n[nH]c2nccc(CCc3ccccc3)c12>>CC(C)(C)C(=O)OC[C@H]1O[C@@H](Oc2n[nH]c3nccc(CCc4ccccc4)c23)[C@H](OC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@@H]1OC(=O)C(C)(C)C,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20050227959A1,CCOC(=O)c1csc2c1CCCC2=O.CI>>CCOC(=O)c1csc2c1CCC(C)C2=O,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20060142280A1,CC1(C)OC(=O)Nc2ccc(-c3cccc(CC#N)n3)cc21.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC1(C)OC(=S)Nc2ccc(-c3cccc(CC#N)n3)cc21,,Cc1ccc(C)cc1,,,,val
US20120270838A1,CN.Cc1cc(CI)cc(C)c1Br>>CNCc1cc(C)c(Br)c(C)c1,,CN(C)C=O,,,,val
US20110245232A1,CCCCN1Cc2cc(N)ccc2C1=O.Cc1cc(-c2ccccc2)c(COS(C)(=O)=O)c(C)n1>>CCCCN1Cc2cc(NCc3c(-c4ccccc4)cc(C)nc3C)ccc2C1=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160159773A1,COc1ccc(COCC(C)(C)c2cc(N)n[nH]2)cc1.O=C1OC(=O)c2ccccc21>>COc1ccc(COCC(C)(C)c2cc(N3C(=O)c4ccccc4C3=O)n[nH]2)cc1,,CN(C)C=O,O,CC(=O)O,O=C([O-])O.[Na+],val
US20050026929A1,C1CCOC1.CC(C)(C)OC(=O)NC(=O)OC(C)(C)C>>Cc1cc(CNC(=O)OC(C)(C)C)ccc1C(=O)O,,O,,[Li+].[OH-],,val
US05736284,CCO[PH]([O-])(OCC)C(c1ccccc1)c1ccccc1.CCn1c2ccccc2c2cc(C=O)ccc21>>CCn1c2ccccc2c2cc(C=C(c3ccccc3)c3ccccc3)ccc21,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20080269295A1,CNCCCN(C)c1nccs1.O=C(O)C#Cc1ccccc1>>O=C(C#Cc1ccccc1)NCCCNc1nccs1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20040157886A1,Nc1ccc2c(c1)C(=O)NC2=O.O=C(O)C(=O)N1CCC(Cc2ccccc2)CC1>>O=C(Nc1ccc2c(c1)C(=O)NC2=O)C(=O)N1CCC(Cc2ccccc2)CC1,,CCOCC,,,,val
US20060270679A1,CC(C)(C)OC(=O)N[C@@H](CC(=O)O)Cc1ccc(F)c(F)c1.FC(F)(F)c1cn2c(n1)CNCC2>>CC(C)(C)OC(=O)N[C@@H](CC(=O)N1CCn2cc(C(F)(F)F)nc2C1)Cc1ccc(F)c(F)c1,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US05380852,C=CCOCCCOC(=O)CBr.Oc1ccc(Cl)c2cccnc12>>C=CCOCCCOC(=O)COc1ccc(Cl)c2cccnc12,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05665719,CC(C)(C)OC(=O)N1CCC(Nc2ccccc2O)CC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1CCC(n2c(=O)oc3ccccc32)CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(Oc3ccnc(N)c3)cc(C)c21>>Cc1cc(Oc2ccnc(N)c2)cc2c1C(CC(=O)O)OB2O,,C1CCOC1,CO,[Na+].[OH-],,val
US04273773,Br.O=C(O)Cc1ccc([N+](=O)[O-])cc1C(=O)O>>O=C(O)Cc1ccc(Br)cc1C(=O)O,[Pd],O,,O=N[O-].[Na+],,val
US20140213571A1,COc1ccc(Cl)nc1-c1cc2ccccc2[nH]1>>Oc1ccc(Cl)nc1-c1cc2ccccc2[nH]1,,ClCCl,,BrB(Br)Br,,val
US20030191160A1,O=S(Cl)Cl.OCc1cccc2c1nc(-c1c(F)cccc1F)n2Cc1c(F)cccc1F>>Fc1cccc(F)c1Cn1c(-c2c(F)cccc2F)nc2c(CCl)cccc21,,ClC(Cl)Cl,,,,val
US04655816,CCI.CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)F)c(C)c1O>>CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)F)c(C)c1OCC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130231313A1,CC(C)(NC(=O)[C@](C)(NC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(C(F)(F)F)c1)C(=O)O.N>>CC(C)(NC(=O)[C@](C)(NC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(C(F)(F)F)c1)C(N)=O,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US05880162,CC(=O)Cl.CCOc1ccc(C(C=C(F)CO)C2CC2)cc1>>CCOc1ccc(C(C=C(F)COC(C)=O)C2CC2)cc1,,c1ccncc1,,c1ccccc1,,val
US20050100978A1,CC(C)(C)OC(=O)NCCCCCCNC(=O)c1ccc(N)cc1.CCO/C(=C1\C(=O)N(C(C)=O)c2ccccc21)c1ccccc1.CN(C)C=O>>NCCCCCCNC(=O)c1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1.[NH4+].[OH-],,CN(C)C=O,CO,ClCCl,,val
US20020147334A1,CCOC(=O)C[C@H](Cc1ccc(OCCCNC2=NCCCN2)cc1)c1ccccc1>>O=C(O)C[C@H](Cc1ccc(OCCCNC2=NCCCN2)cc1)c1ccccc1,,CCO,,C1CCOC1,[Na+].[OH-],val
US20050222192A1,CCOC(=O)Cc1ccccn1.COC(OC)N(C)C>>COC(=O)C(=CN(C)C)c1ccccn1,,CCOC(C)=O,,[Cl-].[NH4+],,val
US04659718,CC(C)Br.Cn1cc(-c2nnn[nH]2)c(=O)c2ccccc21>>CC(C)N1NN=C(c2cn(C)c3ccccc3c2=O)N1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130116235A1,CN1CCc2nc(Nc3cc(-c4ccnc(-n5ncc6c7c(sc6c5=O)CCCC7)c4C=O)cn(C)c3=O)sc2C1>>CN1CCc2nc(Nc3cc(-c4ccnc(-n5ncc6c7c(sc6c5=O)CCCC7)c4CO)cn(C)c3=O)sc2C1,,CO,,[BH4-].[Na+],,val
US20120083501A1,COC1CC[C@@H]2[C@@H](C1)Oc1ccc(Br)cc1C21N=C(N)N(C)C1=O.OB(O)c1cc(F)cc(Cl)c1>>COC1CC[C@@H]2[C@@H](C1)Oc1ccc(-c3cc(F)cc(Cl)c3)cc1C21N=C(N)N(C)C1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20140004174A1,CCOC(=O)c1ccc(N)c(NCc2ccccc2)c1.CCOC(OCC)OCC>>CCOC(=O)c1ccc2ncn(Cc3ccccc3)c2c1,Cl,CCO,,,,val
US20060074102A1,NC(=O)CS.O=Cc1c(Br)cncc1Br>>NC(=O)c1cc2c(Br)cncc2s1,,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120322785A1,COc1ccc(CN)cc1.Cc1cc(C(O)(O)C(F)(F)F)ncc1-c1ccc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c1>>COc1ccc(C/N=C(/c2cc(C)c(-c3ccc4cc(NC(=O)[C@@H]5C[C@@H]5F)ncc4c3)cn2)C(F)(F)F)cc1,,Cc1ccccc1,,CC(=O)O,,val
US20100105655A1,CCOC(=O)C(Br)C(=O)OCC.c1ccc(CN2CCNCC2)cc1>>CCOC(=O)C(C(=O)OCC)N1CCN(Cc2ccccc2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080119518A1,COc1ccc(-c2cc(C)no2)nc1CO[Si](C)(C)C(C)(C)C>>COc1ccc(-c2cc(C)no2)nc1CO,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090018132A1,CC(OCC1(c2ccc(F)cc2)CCN(C(=O)OC(C)(C)C)CC1)c1cc(Br)cc2cn(COCC[Si](C)(C)C)nc12>>CC(OCC1(c2ccc(F)cc2)CCNCC1)c1cc(Br)cc2c[nH]nc12,,O=C(O)C(F)(F)F,,,,val
US20090274632A1,COc1ccc(CNCc2ccccc2)cc1.N#Cc1ccc(S(=O)(=O)Cl)cc1>>COc1ccc(CN(Cc2ccccc2)S(=O)(=O)c2ccc(C#N)cc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20060089367A1,CCCCC(=O)Cl.Fc1cc2nc(COc3ccccc3)n(Cc3ccc(Cl)cc3)c2cc1N1CCNCC1>>CCCCC(=O)N1CCN(c2cc3c(cc2F)nc(COc2ccccc2)n3Cc2ccc(Cl)cc2)CC1,,ClCCl,,,,val
US20090264437A1,CSc1nccc(OC[C@H](C)CN2CCN(c3cc(C4CCC4)nc(C(C)(C)C)n3)CC2)n1.OO>>C[C@@H](COc1ccnc(O)n1)CN1CCN(c2cc(C3CCC3)nc(C(C)(C)C)n2)CC1,,CC(=O)O,,O=C([O-])O.[Na+],,val
US06265411B1,CCOC(=O)Cc1ccc(Br)cc1[N+](=O)[O-]>>O=C1Cc2ccc(Br)cc2N1,[Fe],CC(=O)O,,,,val
US20150011528A1,CCC(Br)C(=O)OC.Cc1ccc(C(=O)N=c2[nH]c3ccc(CO)cc3s2)cc1>>CCC(C(=O)OC)n1c(=NC(=O)c2ccc(C)cc2)sc2cc(CO)ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US03931269,CCNCC.COc1ccc2cc(C(O)C(=O)O)ccc2c1>>CC[NH2+]CC.COc1ccc2cc(C(O)C(=O)[O-])ccc2c1,,CCCCCC,,,,val
US20150329538A1,Cc1ccc(S(=O)(=O)n2ccc(C(=O)OC(C)(C)C)c2[C@@H](C)NC(=O)OC(C)(C)C)cc1.O=C(O)C(F)(F)F>>Cc1ccc(S(=O)(=O)n2ccc(C(=O)O)c2[C@@H](C)N)cc1.O=C(O)C(F)(F)F,,ClCCl,,O,,val
US20030083238A1,CC1CCC(N2CCN(c3ccc(C(=O)NN)cc3)CC2)CC1.O=C(Cl)c1ccc(I)cc1>>CC1CCC(N2CCN(c3ccc(C(=O)NNC(=O)c4ccc(I)cc4)cc3)CC2)CC1,,C1CCOC1,,O,c1ccncc1,val
US20090143472A1,COC[C@@H](NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)O.NCc1ccccc1>>COC[C@@H](NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)NCc1ccccc1,,C1CCOC1,CCOC(C)=O,CC(C)COC(=O)Cl,CN1CCOCC1,val
US04732901,C#CCCCCCCCCCCC.O=Cc1occc1Br>>CCCCCCCCCCCC#Cc1ccoc1C=O,,ClCCl,,,,val
US05783572,COc1nc2cc(Cl)c(Cl)c(C(C)Cl)c2nc1OC.c1c[nH]cn1>>COc1nc2cc(Cl)c(Cl)c(C(C)n3ccnc3)c2nc1OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110166184A1,Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)OC(C)(C)C.O=S(=O)(c1ccccc1)N1OC1c1ccccc1>>Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2O)ccc1C(=O)OC(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120028953A1,COc1ccc(N)nn1.O=C(Oc1ccc([N+](=O)[O-])cc1)N1CC(Oc2ccc(-c3ccccc3F)cn2)C1>>COc1ccc(NC(=O)N2CC(Oc3ccc(-c4ccccc4F)cn3)C2)nn1,,CN(C)C=O,,[H-].[Na+],,val
US20150315209A1,CNC1CCOCC1.O=C(O)C1CCN(c2cnccc2-n2cc(Cl)cn2)CC1>>CN(C(=O)C1CCN(c2cnccc2-n2cc(Cl)cn2)CC1)C1CCOCC1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US03992535,CCN1C(C(=O)OC)=C(O)c2ccc3ccccc3c2S1(=O)=O.Nc1ccccc1>>CCN1C(C(=O)Nc2ccccc2)=C(O)c2ccc3ccccc3c2S1(=O)=O,,Cc1ccccc1C,,,,val
US20120289505A1,COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O.Fc1ccccc1N=C=S>>COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=S)Nc4ccccc4F)cc3)cc2C1=O,,C1CCOC1,,,,val
US20130030002A1,Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C(=O)C=Cc3c(F)cccc3F)cs2)CC1.NO>>Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C(C=Cc3c(F)cccc3F)=NO)cs2)CC1,,CO,,Cl,,val
US03961062,O=C1NCC(C2CCCCC2)c2ccccc21>>O=c1[nH]cc(C2CCCCC2)c2ccccc12,,ClC(Cl)Cl,,CO,,val
US20090226398A1,Fc1cccc(-c2nc3cn[nH]cc-3n2)c1F.O=[N+]([O-])c1cc(Br)ccc1CBr>>O=[N+]([O-])c1cc(Br)ccc1Cn1cc2nc(-c3cccc(F)c3F)nc-2cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120022056A1,CC1CC(=O)CCN1C(=O)OC(C)(C)C.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC1CC(OS(=O)(=O)C(F)(F)F)=CCN1C(=O)OC(C)(C)C,,C1CCOC1,CCCCCC,[Cl-].[NH4+],,val
US04003913,BrP(Br)Br.SCCc1c[nH]c2ccccc12>>BrCCc1c[nH]c2ccccc12,,ClCCl,,CCOCC,,val
US20100130468A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1cc(Br)cc2c(C3CCSC(c4ccccc4)C3)c[nH]c12>>CCOC(=O)c1cc(Br)cc2c(C3CCSC(c4ccccc4)C3)cn(C(=O)OC(C)(C)C)c12,,CC#N,,CN(C)c1ccccn1,,val
US07687510B2,CCOC(=O)CC(C)=O.NC(=O)Nc1cccc(C(F)(F)F)c1.O=Cc1ccc(Br)cc1>>CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)NC1c1ccc(Br)cc1,,C1CCOC1,,Cl,,val
US05168103,CC(C)(C)OC(=O)NCCCN.N#CCBr>>CC(C)(C)OC(=O)NCCCNCC#N,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20060074102A1,O=C(O)c1cc2c(Nc3ccc(-c4ccccc4)cc3)cncc2[nH]1>>c1ccc(-c2ccc(Nc3cncc4[nH]ccc34)cc2)cc1,[Cu],c1ccc2ncccc2c1,,,,val
US20060069110A1,CSc1nccc(N(C)c2cccc(-c3ccccc3)n2)n1.O=C(OO)c1cccc(Cl)c1>>CN(c1cccc(-c2ccccc2)n1)c1ccnc(S(C)=O)n1,,ClCCl,,,,val
US05108486,CC(=O)OC(C)=O.CCNc1cc(F)c([N+](=O)[O-])cc1F>>CCN(C(C)=O)c1cc(F)c([N+](=O)[O-])cc1F,O=S(=O)(O)O,,,O,,val
US20030216442A1,BrCc1nc2ccccc2s1.Nc1ccc2c(O)cccc2c1>>Nc1ccc2c(OCc3nc4ccccc4s3)cccc2c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20120015907A1,CCOC(=O)C(CCCCN(c1nc2oc(-c3ccc(C)cc3)c(C(=O)NC)c2cc1C1CC1)S(C)(=O)=O)S(C)(=O)=O>>CNC(=O)c1c(-c2ccc(C)cc2)oc2nc(N(CCCCC(C(=O)O)S(C)(=O)=O)S(C)(=O)=O)c(C3CC3)cc12,,CCO,,[Na+].[OH-],,val
US06350749B1,Cc1ccnc2c1C(=O)CC(c1sccc1Cl)C2.O=S(=O)(Cl)Cl>>Cc1ccnc2c1C(=O)CC(c1sc(Cl)cc1Cl)C2,,CCOC(C)=O,,c1ccncc1,,val
US20140243336A1,Cc1cc(C)nc(Nc2cc(Br)cnc2C#N)c1.OO>>Cc1cc(C)nc(Nc2cc(Br)cnc2C(N)=O)c1,,CS(C)=O,O,[Na+].[OH-],,val
US20090042854A1,Cc1ccccc1[C@@H]1[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CN2C(=O)C(N3CCC(=O)CC3)C[C@@H]12>>Cc1ccccc1[C@@H]1[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CN2C(=O)C(N3CCC(O)CC3)C[C@@H]12,,CO,,[BH4-].[Na+],,val
US20060084680A1,BrCCCBr.Cc1coc2cc(O)ccc12>>Cc1coc2cc(OCCCBr)ccc12,,[Na+],[OH-],,,val
US20110009421A1,C=O.COc1ccc(CCNc2nccc(-c3cccc(NC(=O)CC(C)N)c3)n2)cc1OC.Cl.[BH3-]C#N>>COc1ccc(CCNc2nccc(-c3cccc(NC(=O)CC(C)N(C)C)c3)n2)cc1OC.Cl,,CC(=O)O,CO,CCN(CC)CC,,val
US04904671,O=[N+]([O-])c1cnccc1NCCCCO>>Nc1cnccc1NCCCCO,[Ni],CCO,,,,val
US20080058378A1,Cc1cc(F)c2[nH]c(=O)n(C3CCN(C(=O)OC(C)(C)C)CC3)c2c1.Cl.ClCCl>>Cc1cc(F)c2[nH]c(=O)n(C3CCNCC3)c2c1.Cl.Cl,,C1COCCO1,ClCCl,,,val
US20090118324A1,BrBr.O=c1ccn(C2CC2)c2c(F)cc(F)c(Nc3ccc(I)cc3F)c12>>O=c1c(Br)cn(C2CC2)c2c(F)cc(F)c(Nc3ccc(I)cc3F)c12,,CC(=O)O,,,,val
US04520193,CC(=O)CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)OC(C)(C)C)C2SC1>>CC(=O)CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(N)C2SC1,,CC#N,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20090192162A1,CCOC(C)=O.O=C(O)COc1ccc(Sc2cc(O)cc(Br)c2)cc1Cl.OCCCN1CCOCC1>>CCOC(=O)COc1ccc(Sc2cc(Br)cc(OCCCN3CCOCC3)c2)cc1Cl,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20110224155A1,N#Cc1c(N)cccc1C1CC1.O=C=NC(=O)c1ccccc1>>Nc1nc(=O)[nH]c2cccc(C3CC3)c12,,C1COCCO1,,[Na+].[OH-],,val
US04254127,CCOC(=O)N1CCC(=O)CC1.CCOP(=O)(CC(=O)c1cccc(OC)c1)OCC>>CCOC(=O)N1CC=C(CC(=O)c2cccc(OC)c2)CC1,,O,,C1CCOC1,[H-].[Na+],val
US20060148858A1,CCOC(=O)C(C)(C)Br.COc1ccc(O)cc1OCc1ccccc1>>CCOC(=O)C(C)(C)Oc1ccc(OC)c(OCc2ccccc2)c1,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US04778800,CCOC(=O)c1ncc2[nH]c3cccc(C(C)OCC)c3c2c1C>>CCOC(C)c1cccc2[nH]c3cnc(C(=O)O)c(C)c3c12,,CC(=O)O,,CCO,[Na+].[OH-],val
US20040077669A1,CC#CCOc1cc(C(C)(O)c2ccccc2)ncn1.CN1CCN(C)C1(F)F>>C=C(c1ccccc1)c1cc(OCC#CC)ncn1.c1cncnc1,,CC#N,,O,,val
US20100160388A1,COc1cc(NC(=O)N2C=CC(=O)C[C@H]2c2ccc(F)cc2)c(Br)cc1C(=O)O.N>>COc1cc(NC(=O)N2C=CC(=O)C[C@H]2c2ccc(F)cc2)c(Br)cc1C(N)=O,,C1COCCO1,ClCCl,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20050014806A1,Fc1cc(-c2cc(CNc3ccon3)on2)cc(F)c1N1CCNCC1.O=Cc1ccc(OCC(=O)O)cc1>>O=Cc1ccc(OCC(=O)N2CCN(c3c(F)cc(-c4cc(CNc5ccon5)on4)cc3F)CC2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US06150373,CC(C)(C)[Si](OCc1cccc(N2C(=O)N(c3ccccc3Br)Cc3cnc(S(C)(=O)=O)nc32)c1)(c1ccccc1)c1ccccc1.Nc1ccccc1>>CC(C)(C)[Si](OCc1cccc(N2C(=O)N(c3ccccc3Br)Cc3cnc(Nc4ccccc4)nc32)c1)(c1ccccc1)c1ccccc1,,Cl,,,,val
US20110065699A1,O=Cc1c(F)cccc1Br>>OCc1c(F)cccc1Br,,CO,,[BH4-].[Na+],,val
US20070105819A1,Nc1cc(C(=O)O)ccc1Sc1cc(Cl)ccc1C(=O)O>>O=C(O)c1ccc2c(c1)NC(=O)c1ccc(Cl)cc1S2,,C1CCOC1,,Cl,O,val
US20140045831A1,CC(C(=O)Nc1ccc2[nH]c(=O)n(Cc3ccc(Cl)cc3)c2n1)N(C)C(=O)OC(C)(C)C.Cl>>CNC(C)C(=O)Nc1ccc2[nH]c(=O)n(Cc3ccc(Cl)cc3)c2n1.Cl,,C1CCOC1,CCOC(C)=O,,,val
US06066739,COC(=O)c1cc(C)c(C(O)c2cc(-n3ccnc3)ccc2C)c(C)c1.COc1ccc2cc([C@H](C)C(=O)Cl)ccc2c1>>COC(=O)c1cc(C)c(C(OC(=O)[C@@H](C)c2ccc3cc(OC)ccc3c2)c2cc(-n3ccnc3)ccc2C)c(C)c1,,CN(C)C=O,Cc1ccccc1,O,c1ccncc1,val
US05925768,CC1(C)C(=O)[C@@]2(C)CC[C@@H]1C2.NO>>CC1(C)C(=NO)[C@@]2(C)CCC1C2,,CO,O,Cl,CC(=O)[O-].[Na+],val
US20110118245A1,O=S(Cl)Cl.O=c1[nH]cnc2ccc(I)cc12>>Clc1ncnc2ccc(I)cc12,CN(C)C=O,,,,,val
US05276049,COC(=O)CCN1CCN(c2ccc(-c3ccc(C#N)cc3)cc2[N+](=O)[O-])C1=O>>COC(=O)CCN1CCN(c2ccc(-c3ccc(C#N)cc3)cc2N)C1=O,[Pd],CCOC(C)=O,,[H][H],,val
US06387911B1,CCSc1ccccc1CO.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCSc1ccccc1CN=[N+]=[N-],,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20150105367A1,COC(CBr)OC.Nc1cc(Cl)ncc1C=O>>Clc1cc2ncc(Br)cc2cn1,,CC#N,CCOC(C)=O,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US05416099,COC(=O)[C@H](CNC(=O)OC(C)(C)C)NS(=O)(=O)c1ccccc1>>COC(=O)[C@H](CN)NS(=O)(=O)c1ccccc1,,CCOC(C)=O,,Cl,,val
US20100081643A1,CCOC(=O)CBr.Fc1cc2[nH]ccc2cc1Br>>CCOC(=O)Cn1ccc2cc(Br)c(F)cc21,,C1CCOC1,,[H-].[Na+],,val
US20100216810A1,CC(C)(C#N)c1cccc(C(=O)O)c1Cl.N#Cc1c(Oc2cccc(N)c2)ccc2nc(NC(=O)C3CC3)sc12>>CC(C)(C#N)c1cccc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3C#N)c2)c1Cl,,C1CCOC1,CCOC(C)=O,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20160264578A1,CNC.COc1cccc(-n2c(=O)c3c(CBr)n(-c4ccc([N+](=O)[O-])cc4)nc3n(Cc3c(F)cccc3F)c2=O)c1F>>COc1cccc(-n2c(=O)c3c(CN(C)C)n(-c4ccc([N+](=O)[O-])cc4)nc3n(Cc3c(F)cccc3F)c2=O)c1F,,C1CCOC1,,,,val
US20160000760A1,CS/C(=N\C#N)Nc1cc(Cl)c(-c2ccc(C(=O)OC(C)(C)C)cc2)c(C(F)(F)F)c1.NN>>CC(C)(C)OC(=O)c1ccc(-c2c(Cl)cc(Nc3n[nH]c(N)n3)cc2C(F)(F)F)cc1,,CCO,,,,val
US05547975,C=CC(=O)O.CC(C)c1ccccc1S>>CC(C)c1ccccc1SCCC(=O)O,,CCOC(C)=O,,,,val
US05990137,COc1cc(C=O)ccc1O.COc1ccc(N)cc1>>COc1ccc(N=Cc2ccc(O)c(OC)c2)cc1,,CO,,CCOCC,,val
US06423869B1,CC(C)(C)OC[C@H](N)C(=O)N[C@@H](CO)[C@@H](O)[C@@H](O)[C@H](O)C(=O)N[C@@H](CC(=O)OC(c1ccccc1)c1ccccc1)c1ccccc1>>N[C@@H](CO)C(=O)N[C@@H](CO)[C@@H](O)[C@@H](O)[C@H](O)C(=O)N[C@@H](CC(=O)O)c1ccccc1,,CCOC(C)=O,,Cl,,val
US04885283,CCOP(=O)(CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)c1ccccc1)CC(CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC>>CNC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)CP(=O)(O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)c1ccccc1,,Br,CC(=O)O,CCOCC,,val
US20140309208A1,CCOc1c(OCC)c(=O)c1=O.Nc1cccc(C(=O)N2CC[C@@H](O)C2)c1O>>CCOc1c(Nc2cccc(C(=O)N3CC[C@@H](O)C3)c2O)c(=O)c1=O,,CCO,,,,val
US20060223868A1,BrBr.Cc1nc2cc(N)ccc2s1>>Cc1nc2c(Br)c(N)ccc2s1,,ClC(Cl)Cl,,[NH4+].[OH-],,val
US20090239896A1,CCOC(=O)CN=[N+]=[N-].COc1cccc([N+](=O)[O-])c1C>>CCOC(=O)C(=Cc1cnccc1OC)N=[N+]=[N-],,CCO,,,,val
US20160002209A1,Nc1ccc(I)cc1F.c1cn[nH]c1>>Nc1ccc(-n2cccn2)cc1F,,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140364620A1,CC1(C)OCC(CCO)(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CO1.O=[N+]([O-])c1ncc[nH]1>>CC1(C)OCC(CCn2ccnc2[N+](=O)[O-])(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CO1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160108050A1,C=C(CCO)c1cc(C#N)cc(NC(=O)OC(C)(C)C)c1Cl>>CC(CCO)c1cc(C#N)cc(NC(=O)OC(C)(C)C)c1Cl,O=[Pt]=O,CCO,,,,val
US04066772,O=C1NCN(c2ccccc2)C12CCNCC2.O=c1[nH]c2ccccc2n1CCCCl>>O=C1NCN(c2ccccc2)C12CCN(CCCn1c(=O)[nH]c3ccccc31)CC2,,CC(=O)CC(C)C,O,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20150183802A1,Cc1cc2cc(O)c(F)cc2c(=O)[nH]1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cc2cc(OS(=O)(=O)C(F)(F)F)c(F)cc2c(=O)[nH]1,CN(C)c1ccncc1,O,c1ccncc1,,,val
US20090318475A1,COc1ccc(/C=C(\Cl)[N+](=O)[O-])cc1.Oc1cc(O)ncn1>>COc1ccc(-c2coc3nc[nH]c(=O)c23)cc1,,CCO,,C1CCC2=NCCCN2CC1,,val
US20050234255A1,COc1ccc(Cl)cc1.C[SiH](C)Cl>>COc1ccc([SiH](C)C)cc1,,C1CCOC1,,[Cl-].[Li+],,val
US20060166964A1,C=C(CBr)C(=O)O.C=Cc1ccccc1-c1[nH]c2cc(C(=O)OC)ccc2c1C1CCCCC1>>C=Cc1ccccc1-c1c(C2CCCCC2)c2ccc(C(=O)OC)cc2n1CC(=C)C(=O)O,,C1CCOC1,CN(C)C=O,[H][H],[H-].[Na+],val
US20070197558A1,Cc1ccc(C#N)c(N=CN(C)C)n1.Nc1cc(Br)ccc1Sc1ccccc1>>Cc1ccc2c(Nc3cc(Br)ccc3Sc3ccccc3)ncnc2n1,,CC(=O)O,,,,val
US20090131468A1,CI.O=CC1CCC(c2cc3ccccc3o2)CC1>>CC1(C=O)CCC(c2cc3ccccc3o2)CC1,,ClCCl,,CC(C)(C)[O-].[K+],,val
US20140296064A1,CN(C)C(=O)Cl.Clc1csc(Cl)n1>>CN(C)C(=O)c1sc(Cl)nc1Cl,,C1CCOC1,O,CC(C)NC(C)C,[Li]CCCC,val
US20060004069A1,CCI.O=c1[nH]nc(Cc2ccc([N+](=O)[O-])cc2)o1>>CCn1nc(Cc2ccc([N+](=O)[O-])cc2)oc1=O,,O,,CN(C)C=O,[H-].[Na+],val
US04159273,C=CCc1c(O)c(C(C)=O)cc2c1CCCC2>>CCCc1c(O)c(C(C)=O)cc2c1CCCC2,[Pd],CCO,,[H][H],,val
US20030114442A1,O=C(Cc1ccc([N+](=O)[O-])cc1)N1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1>>Nc1ccc(CC(=O)N2CCN(CCCCC3(C(=O)NCC(F)(F)F)c4ccccc4-c4ccccc43)CC2)cc1,[Ni],CO,,[H][H],,val
US20160152609A1,COc1cc2c(cc1OC)-n1cnc(C(=O)N(C)C(C)(C)C)c1CC2.O=C1CCC(=O)N1Br>>COc1cc2c(cc1OC)-n1c(Br)nc(C(=O)N(C)C(C)(C)C)c1CC2,,CC#N,,O,,val
US04931436,C1CNCC(CCN2CCCC2)C1.O=C1Nc2cccnc2N(C(=O)Cl)c2cc(Cl)ccc21>>O=C1Nc2cccnc2N(C(=O)N2CCCC(CCN3CCCC3)C2)c2cc(Cl)ccc21,,CO,ClCCl,,,val
US20120010190A1,CON(C)C(=O)CC(c1ccc(Br)cc1)c1ccccc1C.Cc1cc(Br)ccn1>>Cc1cc(C(=O)CC(c2ccc(Br)cc2)c2ccccc2C)ccn1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20140200257A1,CC(C)(C)[Si](C)(C)Cl.CCCCCCCCCCCCCCCCCCC(O)CO>>CCCCCCCCCCCCCCCCCCC(O)CO[Si](C)(C)C(C)(C)C,,CN(C)C=O,,c1c[nH]cn1,,val
US04252738,COC1(C)OC2CCC2O1.C[Si](C)(C)I>>CC(=O)O[C@@H]1CC[C@H]1I,,ClCCl,,,,val
US20120232056A1,COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCN(C(=O)c4ccccc4)CC3)nc2c1>>O=C(O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCN(C(=O)c4ccccc4)CC3)nc2c1,,CO,O,[Na+].[OH-],,val
US20130102776A1,O=C1COc2c1ccc(O)c2CN1CCOCC1.O=Cc1c[nH]c2ncccc12>>O=C1/C(=C/c2c[nH]c3ncccc23)Oc2c1ccc(O)c2CN1CCOCC1,,CO,,C1CCNCC1,,val
US20010051645A1,COc1ccc(Oc2c(C)cc(C=O)cc2C)cc1C(C)C.NNC(N)=O>>COc1ccc(Oc2c(C)cc(C=NNC(N)=O)cc2C)cc1C(C)C,,CCO,,CC(=O)[O-].[Na+],,val
US20080039464A1,CC(C)(Br)C(=O)Nc1cc(C(C)(C)C)on1.Sc1cccs1>>CC(C)(Sc1cccs1)C(=O)Nc1cc(C(C)(C)C)on1,,CCO,,[K+].[OH-],,val
US20020065418A1,COC(=O)c1ccc(OC)c([N+](=O)[O-])n1.NC1CCCCC1>>COC(=O)c1ccc(NC2CCCCC2)c([N+](=O)[O-])n1,,CN(C)C=O,,,,val
US20040092535A1,C[C@@H]1CO[C@@H](CN(C)C)CN1Cc1ccccc1>>C[C@@H]1CO[C@H](CN(C)C)CN1,[Pd],CCO,,,,val
US20090163464A1,C1COCCN1.O=C(O)c1ccc2nc(N3CC[C@@H](N4CCCCC4)C3)sc2c1>>O=C(c1ccc2nc(N3CC[C@@H](N4CCCCC4)C3)sc2c1)N1CCOCC1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150175623A1,CCOC(=O)[C@@H](Cc1ccccc1OCC(F)(F)F)Oc1ncnc2sc(-c3ccc(F)cc3)c(Br)c12.Cc1c(B2OC(C)(C)C(C)(C)O2)ccc(O)c1Cl>>CCOC(=O)[C@@H](Cc1ccccc1OCC(F)(F)F)Oc1ncnc2sc(-c3ccc(F)cc3)c(-c3ccc(O)c(Cl)c3C)c12,,C1CCOC1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040229900A1,ClC[C@@H]1CO1.N#Cc1ccc(O)c(N)c1>>N#Cc1ccc2c(c1)NC[C@H](CO)O2,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20160212997A1,CC(c1ccc(C(F)(F)F)nc1)S(C)(=N)=O.N#CBr>>CC(c1ccc(C(F)(F)F)nc1)S(C)(=O)=NC#N,CN(C)c1ccncc1,ClCCl,,,,val
US20140256546A1,C1COCCN1.COc1c(-c2cnc(C(F)(F)F)nc2Cl)cnn(C)c1=O>>Cn1ncc(-c2cnc(C(F)(F)F)nc2N2CCOCC2)c(O)c1=O,,O,,,,val
US20130131050A1,CC[O-].CS(=O)c1nc2c(c(=O)n1-c1ccc(OCC(F)(F)F)cc1)CCC(=O)N2>>CCOc1nc2c(c(=O)n1-c1ccc(OCC(F)(F)F)cc1)CCC(=O)N2,,C1CCOC1,,O,,val
US20150111876A1,Cc1nc(CO)c2cc(C3CCCCC3)sc2n1.O=S(Cl)Cl>>Cc1nc(CCl)c2cc(C3CCCCC3)sc2n1,,CN(C)C=O,,ClCCl,,val
US20020173527A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.Cc1c[nH]c2cc(C(=O)O)ccc12>>CCCCOC(=O)n1cc(C)c2ccc(C(=O)O)cc21,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US06306889B1,NC(=O)C1c2ccccc2Oc2ccccc21>>NCC1c2ccccc2Oc2ccccc21,,C1COCCO1,,CC(=O)O,[Na],val
US20100113391A1,CCOC(=O)CCCNC(=O)c1cc(F)c(F)cc1NC1CCCC1.O=C(Cl)CCl>>CCOC(=O)CCCNC(=O)c1cc(F)c(F)cc1N(C(=O)CCl)C1CCCC1,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20150284409A1,COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6(C)CC6)C[C@H]5C=CCC[C@@H](C)O[C@@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N4C3)nccc2c1>>COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6(C)CC6)C[C@H]5C=CCC[C@@H](C)O[C@@H](C)[C@H](N)C(=O)N4C3)nccc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130053382A1,CCCC[Sn](Cl)(CCCC)CCCC.FC(F)(F)c1ccn(C2CCCCO2)n1>>CCCC[Sn](CCCC)(CCCC)c1cc(C(F)(F)F)nn1C1CCCCO1,,C1CCOC1,CCOC(C)=O,[Li]CCCC,,val
US20070054924A1,CCOC(=O)c1nnn(Cc2ccc(OC)cc2)c1N.CS(=O)(=O)Cl>>COc1ccc(Cn2nnc(C(=O)O)c2NS(C)(=O)=O)cc1,,c1ccncc1,,,,val
US20110319380A1,O=C(OCC1c2ccccc2-c2ccccc21)N1CCC2(CC1)Cc1nc3cc(Br)ccc3c(=O)n1C2>>O=c1c2ccc(Br)cc2nc2n1CC1(CCNCC1)C2,,ClCCl,O,C1CCNCC1,,val
US20050014810A1,BrCc1ccccc1.O=C(O)c1ccc(F)c([N+](=O)[O-])c1>>O=C(OCc1ccccc1)c1ccc(F)c([N+](=O)[O-])c1,,C1CCOC1,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20040063775A1,CCOC(=O)Cc1cn(Cc2ccccc2)nc1O.Cc1oc(-c2ccccc2)nc1COc1ccc(CCl)cc1>>CCOC(=O)Cc1cn(Cc2ccccc2)nc1OCc1ccc(OCc2nc(-c3ccccc3)oc2C)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100227862A1,N#CCc1ccc(F)cc1.O=C1CCN(Cc2ccccc2)CC1>>N#CC(=C1CCN(Cc2ccccc2)CC1)c1ccc(F)cc1,,CCO,,C,C[O-].[Na+],val
US05106871,COC(=O)CBr.COc1ccc(CCC(=O)c2c(OC)cc(OC)c(CC=C(C)C)c2O)cc1>>COC(=O)COc1c(CC=C(C)C)c(OC)cc(OC)c1C(=O)CCc1ccc(OC)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20060148858A1,CCC(CC)c1nn(-c2ccc(Br)cn2)cc1CCCO.COC(=O)Cc1cccc(OC)c1O>>CCC(CC)c1nn(-c2ccc(Br)cn2)cc1CCCOc1c(CC(=O)OC)cccc1OC,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20130281433A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(Br)sc2c1-c1ccc(Cl)cc1.O=c1[nH]ccc2ccncc12>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-n3ccc4ccncc4c3=O)sc2c1-c1ccc(Cl)cc1,[Cu]I,CCOC(C)=O,CN(C)C=O,CN[C@@H]1CCCC[C@H]1NC,O=C([O-])[O-].[K+].[K+],val
US07470705B2,CC[C@H]1C[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nn[nH]n2)c2nc(OC)ccc2N1C(=O)OC(C)C.CO>>CC[C@H]1C[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(OC)ccc2N1C(=O)OC(C)C,,ClCCl,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050038081A1,Cc1ccc(C(=O)Nc2cccc(N3CCOCC3)c2)cc1NC(=O)c1cccc(OCc2ccccc2)c1>>Cc1ccc(C(=O)Nc2cccc(N3CCOCC3)c2)cc1NC(=O)c1cccc(O)c1,[Pd],CCOC(C)=O,,,,val
US20030191316A1,NCCCOC(=O)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1.O=Cc1ccccc1>>O=C(OCCCNCc1ccccc1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1,,CCOC(C)=O,,CO,[BH4-].[Na+],val
US20040214838A1,CCCCB(O)O.Cc1nc2c(-c3ccc(Br)cc3)n(-c3ccccc3Cl)nc2c(=O)n1CC(F)(F)F>>CCCCc1ccc(-c2c3nc(C)n(CC(F)(F)F)c(=O)c3nn2-c2ccccc2Cl)cc1,,C1CCOC1,O,ClCCl,O=C([O-])[O-].[K+].[K+],val
US05547919,CC(C)(C)c1cccc(O)c1.COC(=O)Cc1c(Cl)ncnc1N(C)C>>COC(=O)Cc1c(Oc2cccc(C(C)(C)C)c2)ncnc1N(C)C,,CCOCC,CN(C)C=O,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20140349993A1,Nc1ccccn1.O=C(O)c1cnn2ccc(-c3ccccc3C(F)(F)F)nc12>>O=C(Nc1ccccn1)c1cnn2ccc(-c3ccccc3C(F)(F)F)nc12,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090209524A1,Cc1nc(N)nc(O)c1Sc1ccc(CO)cc1.O=S(Cl)Cl>>Cc1nc(N)nc(O)c1Sc1ccc(CCl)cc1,,ClCCl,,,,val
US20160152621A1,COc1cc(N)ccc1-c1cnco1.O=C1NCC(C(=O)O)N1>>COc1cc(NC(=O)C2CNC(=O)N2)ccc1-c1cnco1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030232818A1,CC(C)(C)OC(=O)N[C@H]1CCNC1.CCOC(=O)c1cn(CCC#N)c2nc(Cl)c(F)cc2c1=O>>N[C@H]1CCN(c2nc3[nH]cc(C(=O)O)c(=O)c3cc2F)C1,,CC#N,,,,val
US20060229294A1,NCCN.O=[N+]([O-])c1ccc2snc(Cl)c2c1>>NCCNc1nsc2ccc([N+](=O)[O-])cc12,,CC#N,,,,val
US20100130492A1,CC(=O)OC(C)=O.Nc1ncc(-c2nc(N3CCOCC3)c3nc(N4CCNC5(CC5)C4)n(CC(F)(F)F)c3n2)cn1>>CC(=O)N1CCN(c2nc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3n2CC(F)(F)F)CC12CC2,,CO,ClCCl,CCN(CC)CC,,val
US20030166639A1,CCc1ncccc1-c1cccc(C(=O)CC(=O)Nc2cc(C(F)(F)F)c(OCC(F)(F)F)cc2NC(=O)OC(C)(C)C)c1>>CCc1ncccc1-c1cccc(C2=Nc3cc(OCC(F)(F)F)c(C(F)(F)F)cc3NC(=O)C2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06274608B1,Cc1cc2c(cc1C(C)O)C(C)(C)CCC2(C)C.O=Cc1ccc(O)cc1>>Cc1cc2c(cc1C(C)Oc1ccc(C=O)cc1)C(C)(C)CCC2(C)C,,C1CCOC1,O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140005231A1,FC(F)(F)c1cc[nH]n1.Fc1ccc(I)c(Cl)c1>>FC(F)(F)c1ccn(-c2ccc(I)c(Cl)c2)n1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20030105151A1,COc1ccc2c(c1)CC(=O)N2.Cc1c(CCC(=O)O)c[nH]c1C=O>>COc1ccc2c(c1)C(=Cc1[nH]cc(CCC(=O)O)c1C)C(=O)N2,C1CCNCC1,CCO,,,,val
US05128361,Cc1c(S)cccc1Cl.Cl.ClCC1=NCCN1>>Cc1c(Cl)cccc1SCC1=NCCN1.Cl,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US05541229,CC(C)(C)OC(=O)c1ccccc1-c1ccc(CBr)cc1.CCCCC(=O)Nc1ccc(OC)cc1[N+](=O)[O-]>>CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1)c1ccc(OC)cc1[N+](=O)[O-],,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20090209607A1,CC(C)OB1OC(C)(C)C(C)(C)O1.CCCn1cccn1>>CCCn1nccc1B1OC(C)(C)C(C)(C)O1,,C1CCOC1,,[Li]CCCC,,val
US20110294776A1,COC(CC/C(=N\NC(=O)OC(C)(C)C)C1CN(C(=O)OCc2ccccc2)C1)OC>>CC(C)(C)OC(=O)Nn1cccc1C1CN(C(=O)OCc2ccccc2)C1,,CC(=O)O,,,,val
US06211216B1,COCc1cc(-c2c(S(C)(=O)=O)ccc(C(=O)O)c2Cl)no1.O=C1CCCCC1=O>>COCc1cc(-c2c(S(C)(=O)=O)ccc(C(=O)OC3=CC(=O)CCC3)c2Cl)no1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130035292A1,COC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](COC(C)=O)NC(=O)OCc1ccccc1)[C@@H](C)O>>COC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)OCc1ccccc1,,CN(C)C=O,ClCCl,CN1CCOCC1,,val
US20150259346A1,C=O.NCCN1CCC(C(F)(F)F)c2ccccc21>>FC(F)(F)C1CCN2CCNCc3cccc1c32,,CCO,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20060281772A1,COc1cc2ncnc(C3CCN(C(=O)Cl)CC3)c2cc1OC.Nc1ccc(OC(F)F)cc1>>COc1cc2ncnc(C3CCN(C(=O)Nc4ccc(OC(F)F)cc4)CC3)c2cc1OC,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20040048909A1,CCCCCN(Cc1ccc(-c2ccccc2[N+](=O)[O-])cc1)C(=O)Nc1c(F)cc(F)cc1F>>CCCCCN(Cc1ccc(-c2ccccc2N)cc1)C(=O)Nc1c(F)cc(F)cc1F,,CCO,,Cl[Sn]Cl,,val
US20060235029A1,Cc1ccc(C(=O)O)cc1-c1nc(N2CCC(N3CCC(C)CC3)CC2)nc2c1ccc(=O)n2-c1c(F)cccc1F.NCC(F)(F)F>>Cc1ccc(C(=O)NCC(F)(F)F)cc1-c1nc(N2CCC(N3CCC(C)CC3)CC2)nc2c1ccc(=O)n2-c1c(F)cccc1F,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130165464A1,N.O=C(O)c1cn(-c2ccnc(Cl)c2)nc1-c1ccccc1Cl>>NC(=O)c1cn(-c2ccnc(Cl)c2)nc1-c1ccccc1Cl,,ClCCl,O,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20160060257A1,COc1ccc(CN)cc1.O=C1CCC(S(=O)(=O)Cl)CC1>>COc1ccc(CNS(=O)(=O)C2CCC(=O)CC2)cc1,,CN(C)C=O,,CCN(CC)CC,,val
US20130338152A1,CC(=O)O.Nc1ncnc2c1c(-c1cc(OCC3CCCO3)ccc1F)cn2[C@H]1CC[C@@H](N)CC1>>CC(=O)N[C@@H]1CC[C@H](n2cc(-c3cc(OCC4CCCO4)ccc3F)c3c(N)ncnc32)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150223461A1,Cc1cc(CO)nc(Cl)n1>>Cc1cc(C=O)nc(Cl)n1,,CS(C)=O,,CCN(CC)CC,Cl,val
US20120157438A1,C1COCCN1.O=c1c2cc(Cc3ccc(Cl)cc3)c3ccccc3c2ncn1[C@H]1CCOC[C@@H]1O>>O=c1c2cc(Cc3ccc(N4CCOCC4)cc3)c3ccccc3c2ncn1[C@H]1CCOC[C@@H]1O,CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04661592,CCN(CC)CCCl.Cl.O=c1c(CO)cnc2c3ccccc3ccn12>>CCN(CC)CCOCc1cnc2c3ccccc3ccn2c1=O.Cl.Cl,,CCOCC,CN(C)C=O,[H-].[Na+],,val
US20140073620A1,CC(C(N)=O)c1ccccc1CCc1nc(Nc2cnn(C3CCN(C(=O)OC(C)(C)C)CC3)c2)ncc1Cl>>CC(C(N)=O)c1ccccc1CCc1nc(Nc2cnn(C3CCNCC3)c2)ncc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US05550251,CC(C)(C)[Si](C)(C)Cl.OCCCCCO>>C[Si](C)(C)OCCCCCO,,C1CCOC1,,[H-].[Na+],,val
US20040053942A1,CN(C)C=CC(=O)c1c(-c2ccc(F)cc2)nn2cc(C(F)(F)F)ccc12.COc1ccc(COCCCNC(=N)N)cc1>>COc1ccc(COCCCNc2nccc(-c3c(-c4ccc(F)cc4)nn4cc(C(F)(F)F)ccc34)n2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06166037,COC(=O)C1CN(C(=O)OC(C)(C)C)CCC1c1ccccc1>>CC(C)(C)OC(=O)N1CCC(c2ccccc2)C(C(=O)O)C1,,CCO,,[Na+].[OH-],,val
US20070173506A1,CO.COCC(C)=O.NC(N)=S>>COCc1csc(N)n1,,CO,,BrBr,,val
US20100137317A1,C#CC(C)(C)O.COc1ccc(C=O)cc1Cl>>COc1ccc(C(O)C#CC(C)(C)O)cc1Cl,,C1CCOC1,,[Li]CCCC,,val
US20100041684A1,Clc1ccnc(Cl)n1.NCCCO>>OCCCNc1nccc(Cl)n1,,CCOC(C)=O,,CCN(CC)CC,O=C([O-])[O-].[Na+].[Na+],val
US20130281657A1,CC(C)(C)OC(=O)CNC(N)=S.O=CC(Br)C=O>>CC(C)(C)OC(=O)CNc1ncc(C=O)s1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20110021522A1,COc1cccc2cc(C(=O)O)c(=O)oc12.Nc1cccc(N2CCOCC2)c1>>COc1cccc2cc(C(=O)Nc3cccc(N4CCOCC4)c3)c(=O)oc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04897490,Cc1nnnn1C.O=C(c1ccccc1)c1ccccc1>>Cn1nnnc1CC(O)(c1ccccc1)c1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20120028974A1,CCOC(=O)C1(c2nc3c(OC)ccc(-c4cccc(C#N)c4)n3n2)CC1>>COc1ccc(-c2cccc(C#N)c2)n2nc(C3(C(=O)O)CC3)nc12,,C1COCCO1,O,[Li+].[OH-],,val
US06046189,COc1ccc(-c2c(Cl)c(CN)nc3sc4c(c23)CCN(Cc2ccccc2)C4)cc1OC.O=C(Cl)c1cccnc1>>COc1ccc(-c2c(Cl)c(CNC(=O)c3cccnc3)nc3sc4c(c23)CCN(Cc2ccccc2)C4)cc1OC,,c1ccncc1,,Cl,O,val
US20160158377A1,BrCCOCCBr.O=Cc1ccc(O)cc1O>>O=Cc1ccc(OCCOCCBr)cc1O,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US04209616,CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)C(=NO)c3ccccc3)[C@H]2SC1.[N-]=[N+]=C(c1ccccc1)c1ccccc1>>CC(=O)OCC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](NC(=O)C(=NO)c3ccccc3)[C@H]2SC1,,C1CCOC1,,CC(=O)O,,val
US20140206681A1,C[C@H](O)[C@@H]1CC[C@@H](c2nc(Br)c3c(N)nccn23)CN1.N#CBr>>C[C@@H]1OC(=N)N2C[C@H](c3nc(Br)c4c(N)nccn34)CC[C@@H]12,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US05952368,Cc1ccc(C(=O)c2ccc(Cc3ccc(NS(C)(=O)=O)cc3Br)n2C)cc1.N#C[Cu]>>Cc1ccc(C(=O)c2ccc(Cc3ccc(NS(C)(=O)=O)cc3C#N)n2C)cc1,,CN(C)C=O,,[C-]#N.[Na+],,val
US05510362,CC(C)(C)OC(=O)N1CC(CC=O)C1.NNc1ccc(-n2cncn2)cc1>>c1ccc2[nH]c(N3CCC3)cc2c1,,O=S(=O)(O)O,,O=C([O-])[O-].[K+].[K+],,val
US20050043309A1,CC1(C)C(=O)Nc2nc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc2C1=O>>CC1(C)C(=O)Nc2nc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc2C1O,,C1CCOC1,,[BH4-].[Na+],,val
US20030130122A1,Nc1cc(Oc2ncccn2)c(Cl)cc1F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C=Nc1cc(Oc2ncccn2)c(Cl)cc1F,,CCOC(C)=O,,CCN(CC)CC,,val
US05556864,CN1CCCC(COc2ccccc2CCc2cccc(OC(F)F)c2)C1.Cl>>CN1CCCC(COc2ccccc2CCc2cccc(OC(F)F)c2)C1.Cl,,C1COCCO1,,,,val
US20020099047A1,COc1ccc(CCCN2CC[C@H](OC(=O)c3ccc([N+](=O)[O-])cc3)C2)cc1>>COc1ccc(CCCN2CC[C@H](O)C2)cc1,,CO,,[Na+].[OH-],,val
US05599814,CI.COc1c(Cl)cc(NC(=O)OC(C)(C)C)c(C(=O)O)c1Cl>>COC(=O)c1c(NC(=O)OC(C)(C)C)cc(Cl)c(OC)c1Cl,,CN(C)C=O,,O,[H-].[Na+],val
US20140296225A1,N#Cc1ccc2c(c1)CC(N1CCNCC1=O)CC2.O=CCc1ccc2c(c1)COC2=O>>N#Cc1ccc2c(c1)CC(N1CCN(CCc3ccc4c(c3)COC4=O)CC1=O)CC2,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040044052A1,COC(=O)[C@H]1CN(c2ccc3c(c2)SCC(=S)N3C)C(=O)O1.N>>CN1C(=S)CSc2cc(N3CC(C(N)=O)OC3=O)ccc21,,CO,,,,val
US04189595,BrCc1ccccc1.CSC(=Cc1ccccc1Nc1c(Cl)cccc1Cl)S(C)=O>>CSC(=Cc1ccccc1N(Cc1ccccc1)c1c(Cl)cccc1Cl)S(C)=O,,CN(C)C=O,,O,[H-].[Na+],val
US20030186962A1,NCc1ccccc1.O=C[C@@H](COCc1ccccc1)OCc1ccccc1>>C(=NCc1ccccc1)[C@@H](COCc1ccccc1)OCc1ccccc1,,CCOCC,,O=S(=O)([O-])[O-].[Mg+2],,val
US20100130545A1,CCOC(CCNC(=O)C(C)(COC)COC)OCC>>COCC(C)(COC)C(=O)NCCC=O,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120040984A1,CCOC(=O)c1ccc([C@@H]2CC[C@@H](/C=C/C(=O)OC(C)(C)C)CC2)cc1>>CCOC(=O)c1ccc([C@@H]2CC[C@@H](CCC(=O)OC(C)(C)C)CC2)cc1,[Pd],CCO,,[H][H],,val
US20120157460A1,CC(C)(C)OC(=O)N1CCC(=O)C(Br)C1.Nc1cc(Br)ccn1>>CC(C)(C)OC(=O)N1CCc2nc3cc(Br)ccn3c2C1,,Cc1ccccc1,,,,val
US20160039841A1,Cn1c(=O)n(CCCOC2CCCCO2)c(=O)c2c(C(O)c3ccc(Cl)cc3)c(Oc3cccc(Cl)c3)sc21.O=C(O)C(F)(F)F>>Cn1c(=O)n(CCCOC(=O)C(F)(F)F)c(=O)c2c(Cc3ccc(Cl)cc3)c(Oc3cccc(Cl)c3)sc21,,CCOC(C)=O,O,CC[SiH](CC)CC,,val
US20150266867A1,CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)O)cs1.c1ccc2sc(SSc3nc4ccccc4s3)nc2c1>>CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)Sc2nc3ccccc3s2)cs1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090324581A1,CC1(c2ccc(CO)cc2C(F)(F)F)CC1.CCOC(=O)CCN(CC(=O)N1CCc2cc(O)ccc21)C(=O)OC(C)(C)C>>CCOC(=O)CCN(CC(=O)N1CCc2cc(OCc3ccc(C4(C)CC4)c(C(F)(F)F)c3)ccc21)C(=O)OC(C)(C)C,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06255305B1,Clc1nn2c(-c3ccccc3)nnc2cc1-c1ccccc1.O>>O=c1[nH]n2c(-c3ccccc3)nnc2cc1-c1ccccc1,,C1COCCO1,O,[Na+].[OH-],,val
US20120053175A1,COc1cc(B(O)O)cc(OC)c1OC.C[Si](C)(C)CCOCN1C(=O)Cc2cc(Br)cnc21>>COc1cc(-c2cnc3c(c2)CC(=O)N3COCC[Si](C)(C)C)cc(OC)c1OC,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20110218219A1,CCS(=O)(=O)Cl.NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1OCc1cccc(N)c1>>CCS(=O)(=O)Nc1cccc(COc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1,,CCOC(C)=O,c1ccncc1,,,val
US20040192728A1,CCOC(=O)c1cnc2ccc(F)cc2c1>>O=C(O)c1cnc2ccc(F)cc2c1,,CO,,Cl,[Na+].[OH-],val
US04835171,CC(C)C=CN(C(=O)Cl)C(C)(C)C.c1cn[nH]c1>>CC(C)C=CN(C(=O)n1cccn1)C(C)(C)C,CN(C)c1ccncc1,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20160046618A1,CC(C)(C)OC(=O)C[C@](CF)(N[S@](=O)C(C)(C)C)c1cc(Br)ccc1F>>CC(C)(C)[S@@](=O)N[C@@](CF)(CCO)c1cc(Br)ccc1F,,C1CCOC1,,CO,[BH4-].[Li+],val
US20110152296A1,N#CCC(=O)c1ccccc1F.Nc1cccnc1C1OCCO1>>N#Cc1cc2ncccc2nc1-c1ccccc1F,,CCOC(C)=O,Cc1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140275003A1,O=C(Nc1cccc(C(F)(F)F)c1)c1ccc(CO)c(-c2ccnc(N3CCOCC3)c2)c1>>O=Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1,O=[Mn]=O,ClCCl,,,,val
US20090137609A1,CCC(CC)(c1ccc(C#CC2(O[Si](C)(C)C)CCCCC2)c(C)c1)c1ccc(-c2cncc(CC(=O)OC)c2)c(C)c1>>CCC(CC)(c1ccc(C#CC2(O)CCCCC2)c(C)c1)c1ccc(-c2cncc(CC(=O)OC)c2)c(C)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130267510A1,CC(C)(N)C(=O)Nc1ccc(Oc2cccc3c2C2(CC2)CO3)nc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC1(C)NC(=O)N(c2ccc(Oc3cccc4c3C3(CC3)CO4)nc2)C1=O,,ClCCl,,,,val
US20130053409A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)C1CNC1>>CN(C)C1CN(C(=O)OC(C)(C)C)C1,,ClCCl,,CCN(CC)CC,,val
US04243609,CC(=O)Nc1ccc(C(=O)O)c(F)c1.CCO>>CCOC(=O)c1ccc(N)cc1F,,CCO,,CCOCC,FB(F)F,val
US20070203111A1,NCC1(c2ccc3cc(F)ccc3c2)CCCCC1.O=C(O)c1ccc(F)c2ccccc12>>NCC1(c2ccc(F)c3ccccc23)CCCCC1,,CO,,CC#N,O,val
US20030144281A1,CC(=O)OC(C)=O.CN(C(=O)c1ccc2c(c1)nc(NC(=O)c1cccs1)n2CCCO)C1CCCCC1>>CC(=O)OCCCn1c(NC(=O)c2cccs2)nc2cc(C(=O)N(C)C3CCCCC3)ccc21,,C1CCOC1,,CCN(CC)CC,,val
US20090131492A1,CC(C)(C)OC(=O)NCCn1c(C(C)(C)C)cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c(F)cc21>>CC(C)(C)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c(F)cc2n1CCN,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080085887A1,CC(Cc1ccc(F)c(F)c1)NC(=O)c1c(N)ccnc1C(F)(F)F.O=Cc1ncccc1OCc1ccccc1>>CC(Cc1ccc(F)c(F)c1)N1C(=O)c2c(ccnc2C(F)(F)F)NC1c1ncccc1OCc1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,,,val
US20090118292A1,COCCN.ClCc1nc(-c2cccc(-c3cn4ncccc4n3)c2)no1>>COCCNCc1nc(-c2cccc(-c3cn4ncccc4n3)c2)no1,,CCO,,,,val
US06740662B1,C1CCNC1.CCn1c(=O)c(CCCOS(C)(=O)=O)c(-c2cccc(Cl)c2)c2ccc(C)nc21.Cl>>CCn1c(=O)c(CCCN2CCCC2)c(-c2cccc(Cl)c2)c2ccc(C)nc21.Cl,,C1CCOC1,O,[I-].[K+],,val
US20040087658A1,C=CC1(CC(=O)O)CC(C)(C)CC(C)(C)C1.NC(N)=S>>C=CC1(CC(N)=O)CC(C)(C)CC(C)(C)C1,,CC(=O)O,CCO,,,val
US20140323480A1,COC(=O)c1cc(N2CCOCC2)nc(N)c1[N+](=O)[O-]>>COC(=O)c1cc(N2CCOCC2)nc(N)c1N,[Pd],CC(=O)O,CO,,,val
US20100144760A1,CCCC[Sn](CCCC)(CCCC)c1ncccn1.COC(=O)c1nc(C)ccc1I>>COC(=O)c1nc(C)ccc1-c1ncccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,[Cs+].[F-],,val
US04322420,CCNc1ccccc1.Clc1ccc2c(Cl)ncnc2c1>>CCN(c1ccccc1)c1ncnc2cc(Cl)ccc12.Cl,,CCO,,,,val
US06316490B1,CN1CCCC1CCCl.Oc1ccc(S)cc1>>CN1CCCC1CCSc1ccc(O)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080027041A1,COc1ccc(C2=CC(=O)OC2O)cc1.NN>>COc1ccc(-c2cn[nH]c(=O)c2)cc1,,CCO,,O,,val
US20020160040A1,CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)CO.CCO>>CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)CO.CCO,,CCO,,O,,val
US20110237517A1,COC(=O)N1CC(c2c[nH]c3cc(F)ccc23)C2C1CCN2C(=O)C(N)C1CCCCC1.C[C@@H](C(=O)O)N(C)C(=O)OC(C)(C)C>>COC(=O)N1CC(c2c[nH]c3cc(F)ccc23)C2C1CCN2C(=O)C(NC(=O)C(C)N(C)C(=O)OC(C)(C)C)C1CCCCC1,,CCOC(C)=O,CN1CCCC1=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090163508A1,Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.Fc1ccc(-c2cncc(N3CCNCC3)n2)c(F)c1>>Cc1noc(NC(=O)N2CCN(c3cncc(-c4ccc(F)cc4F)n3)CC2)c1C,,C1CCOC1,CCCCCC,,,val
US20150232454A1,CCOc1ncc(C2=CCCCC2)cc1OC>>O=c1[nH]cc(C2CCCCC2)cc1O,[Pd],CO,,,,val
US20110288090A1,CC(C)(C)[S@@](N)=O.COc1nccc2nc(-c3ccc(C(=O)CF)cc3)c(-c3ccccc3)cc12>>COc1nccc2nc(-c3ccc(C(CF)NS(=O)C(C)(C)C)cc3)c(-c3ccccc3)cc12,,C1CCOC1,,[BH4-].[Na+],,val
US20060019197A1,Brc1c2ccccc2cc2cc3ccccc3cc12.OB(O)c1ccccc1>>c1ccc(-c2c3ccccc3cc3cc4ccccc4cc23)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,O,Cc1ccccc1,O=C([O-])O.[Na+],val
US04959092,CC1(C)Cc2cccc(CCl)c2O1.CN(C)C(=O)Nc1ccc(O)cc1>>CN(C)C(=O)Nc1ccc(OCc2cccc3c2OC(C)(C)C3)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20140161725A1,CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@H](NC(=O)OCc1cccc2c1Cc1ccccc1-2)C(=O)OC(C)(C)C)OC(=O)CCCCCCCCCCCCCCC>>CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@H](NC(=O)OCc1cccc2c1Cc1ccccc1-2)C(=O)O)OC(=O)CCCCCCCCCCCCCCC,,O=C(O)C(F)(F)F,,,,val
US20050137168A1,CCI.CCOC(=O)C(O)c1nc(C)n(-c2ccccc2)n1>>CCOC(=O)C(OCC)c1nc(C)n(-c2ccccc2)n1,O=[Ag-],Cc1ccccc1,,,,val
US20080096885A1,C1COCCN1.COC(=O)N(NC(=O)c1c(CBr)c(-c2ccccc2)nc2ccccc12)c1ccccc1>>COC(=O)N(NC(=O)c1c(CN2CCOCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1,,C1CCOC1,,,,val
US20100093730A1,O=C(O)CN1CCCC(c2ccccc2)(c2ccccc2)C1=O.[H]/N=C(\NO)c1ccc(Cl)cc1>>O=C1N(Cc2nc(-c3ccc(Cl)cc3)no2)CCCC1(c1ccccc1)c1ccccc1,,CC(Cl)Cl,,CCN=C=NCCCN(C)C,Cl,val
US20030036558A1,O=C(O)COc1ccc([N+](=O)[O-])cc1C(=O)NCc1ccc(Br)cc1F>>Nc1ccc(OCC(=O)O)c(C(=O)NCc2ccc(Br)cc2F)c1,[Pd],CCO,,[H][H],,val
US20060025433A1,CC1(C)OC1O.N[C@@H]1CC[C@@H](CNc2nc(NCc3ccccc3OC(F)(F)F)ncc2[N+](=O)[O-])CC1>>CC(C)(O)CN[C@@H]1CC[C@@H](CNc2nc(NCc3ccccc3OC(F)(F)F)ncc2[N+](=O)[O-])CC1,,CCO,,,,val
US20090298834A1,CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1>>NC[C@@H]1CC[C@@H](CNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130231335A1,CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CCCC1.NN>>CC[C@@H]1C(=O)N(C)c2cnc(NN)nc2N1C1CCCC1,,CCO,,,,val
US20150307512A1,BrBr.CC(=O)CC(C)(C)O>>CC(C)(O)CC(=O)CBr,,O,,CO,,val
US04082751,CC(C)COc1ccccc1-c1ncc(C(N)=O)c(=O)[nH]1>>CC(C)COc1ccccc1-c1ncc(C#N)c(=O)[nH]1,,O=P(Cl)(Cl)Cl,,,,val
US20090118305A1,Cc1ccc(O)c(N)n1.Nc1ncc(Br)cc1C(=O)O>>Cc1ccc2oc(-c3cc(Br)cnc3N)nc2n1,,O,,[Na+].[OH-],,val
US20160122317A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.COC(=O)Cc1ccc(Cl)cc1>>COC(=O)C(c1ccc(Cl)cc1)C1(O)CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,C1CCOC1,[Li]CCCC,,val
US20100130497A1,CCN(CC)Cc1cc(C=O)ccc1OC.O=C(O)CC(=O)Nc1ccccc1C(=O)O>>CCN(CC)Cc1cc(/C=C/C(=O)Nc2ccccc2C(=O)O)ccc1OC,,Cc1ccccc1,,C1CCNCC1,CC(=O)O,val
US20060135561A1,BrCCc1ccccc1.CCCCC1CNCCC1=O>>CCCCC1CN(CCc2ccccc2)CCC1=O,,CCOCC,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20100087429A1,CCNCC.O=C(O)c1cc(Br)ccc1Oc1cccnc1F>>CCN(CC)C(=O)c1cc(Br)ccc1Oc1cccnc1F,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US05859007,Brc1cccnc1.COc1ccc(N(C(=O)CN2C(=O)CC(=O)Nc3ccccc32)C(C)C)cc1>>COc1ccc(N(C(=O)CN2C(=O)CC(=O)N(c3cccnc3)c3ccccc32)C(C)C)cc1,,CN(C)C=O,,CC(=O)[O-].[K+],,val
US20150005280A1,CC(C)(C)OC(=O)N1CC2CCC(C1)N2C(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)cc12>>O=C(c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)cc12)N1C2CCC1CNC2,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,,val
US04012513,CC=NN(c1ccc(OC)cc1)c1ncnc2cc(Cl)ccc12>>COc1ccc(N(N)c2ncnc3cc(Cl)ccc23)cc1,,CCO,,Cl,Cl,val
US20150167017A1,CC(C)(C)[Si](C)(C)Cl.CCSCO>>CCSCO[Si](C)(C)C(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20030216398A1,BrCc1ccccc1.COc1ccc(C(=O)N2CCNc3ccccc32)cc1OC>>COc1ccc(C(=O)N2CCN(Cc3ccccc3)c3ccccc32)cc1OC,,CN(C)C=O,O,CCOC(C)=O,[H-].[Na+],val
US20110166152A1,CCOC(=O)Nc1nc2ncc(C#C[Si](C)(C)C)nc2s1>>C#Cc1cnc2nc(NC(=O)OCC)sc2n1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080171770A1,CC(=O)c1ccc(C(C)(C)C)s1.N>>CC(C)(C)c1ccc(CCN)s1,CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C,[NH4+],[OH-],CCO,[BH4-].[Na+],val
US06620949B1,CCCO.CCO.O=C1C=CC(=O)O1>>O=C1CCCO1.OCCCCO,,CCCO,,,,val
US06432983B1,C1CCNC1.COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(OCCCCCCCCBr)cc2)cc1>>COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(OCCCCCCCCN3CCCC3)cc2)cc1,,CN(C)C=O,,,,val
US20030181726A1,COc1ccc(C(NC(=O)[C@@H](C)NC[C@H](O)COc2ccccc2)c2ccc(OC)cc2)cc1>>COc1ccc(C(NC[C@@H](C)NC[C@H](O)COc2ccccc2)c2ccc(OC)cc2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160002255A1,COc1ccc(F)c(B(O)O)c1.O=Cc1cc(Cl)ccc1Br>>COc1ccc(F)c(-c2ccc(Cl)cc2C=O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20070043080A1,CC(C)(C)C(=O)ON1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.Cc1ccc(NC(=O)C(C)C)cc1Br>>Cc1ccc(NC(=O)C(C)C)cc1C1=CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030166639A1,CC(C)(C)OC(=O)Nc1cc(C(F)(F)F)c(Cl)cc1NC(=O)CC(=O)c1cccc(-c2ccccn2)c1>>O=C1CC(c2cccc(-c3ccccn3)c2)=Nc2cc(C(F)(F)F)c(Cl)cc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090062259A1,CC(C)(C)OC(=O)N(CCc1ccccc1)Cc1ccc(CCO)cc1>>CC(C)(C)OC(=O)N(CCc1ccccc1)Cc1ccc(CC=O)cc1,,CCOC(C)=O,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US05719141,NC(=O)CI.O=[N+]([O-])c1ccccc1O>>NC(=O)COc1ccccc1[N+](=O)[O-],,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150232435A1,CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.CN1CCC(N2CCNCC2)CC1.O=C(n1ccnc1)n1ccnc1>>CN1CCC(N2CCN(C(=O)NCCCCN3CCN(c4cc(C(F)(F)F)nc(C(C)(C)C)n4)CC3)CC2)CC1,,CO,ClC(Cl)Cl,,,val
US20100093730A1,NCc1nccs1.O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O>>O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)NCc1nccs1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20090197870A1,COc1cc(C(C)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F.O=C1CSC(=S)N1>>COc1cc(C(C)=C2SC(=S)NC2=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,,CCOC(C)=O,,Cc1ccccc1,,val
US20060089367A1,NNc1ccccn1.O=C(O)c1ccc2c(c1)nc(COc1ccccc1)n2Cc1ccc(OC(F)(F)F)cc1>>O=C(NNc1ccccn1)c1ccc2c(c1)nc(COc1ccccc1)n2Cc1ccc(OC(F)(F)F)cc1,,C1CCOC1,,CC(C)N=C=NC(C)C,,val
US20090209532A1,CCOc1cc(C=O)ccc1OCc1ccccc1.O=[N+]([O-])O>>CCOc1cc(C=O)c([N+](=O)[O-])cc1OCc1ccccc1,,ClCCl,,,,val
US20040209857A1,C=CCC(C(=O)OC)c1ccc(CN)cc1.CS(=O)(=O)Cl>>C=CCC(C(=O)OC)c1ccc(CNS(C)(=O)=O)cc1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20140275080A1,Cc1nc(NC(=O)NC(=O)C(C)(C)C)ccc1Oc1ccnc(-c2cn(COC(=O)C(C)(C)C)nn2)c1>>Cc1nc(NC(=O)NC(=O)C(C)(C)C)ccc1Oc1ccnc(-c2c[nH]nn2)c1,,CO,,,,val
US20120277244A1,COC(=O)C(=O)N(C)CC(C)(NC(=O)OC(C)(C)C)c1cc(Br)ccc1F>>CN1CC(C)(c2cc(Br)ccc2F)NC(=O)C1=O,,C1COCCO1,,Cl,,val
US06500853B1,BrCC1CC1.O=C(O)Cc1c[nH]c2ccc(Br)cc12>>O=C(O)Cc1cn(CC2CC2)c2ccc(Br)cc12,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20020128290A1,C#CC(C)(C)Cl.COC(=O)c1ccc(OC)c(O)c1>>C#CC(C)(C)Oc1cc(C(=O)OC)ccc1OC,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150126469A1,CC(=O)OC[C@H]1O[C@@H](n2cc(Cc3ccc(OCCCN4CCCC5(CCN(C(=O)CNC(=O)NCC(C)C)CC5)C4)cc3)c3c(C)cccc32)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>Cc1cccc2c1c(Cc1ccc(OCCCN3CCCC4(CCN(C(=O)CNC(=O)NCC(C)C)CC4)C3)cc1)cn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O,,O,,CO,C[O-].[Na+],val
US20080004271A1,CCOC(=O)CC#N.O=Cc1ccc(Cl)c(Cl)c1>>CCOC(=O)/C(C#N)=C/c1ccc(Cl)c(Cl)c1,C1CCNCC1,Cc1ccccc1,,O,,val
US20100298339A1,Nc1cccc(-c2cccc3nc(Nc4ccc(OCCN5CCCC5)cc4)nn23)c1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1cccc(-c2cccc3nc(Nc4ccc(OCCN5CCCC5)cc4)nn23)c1,,ClC(Cl)Cl,,,,val
US20150183801A1,CC1(O)CCN(c2ccc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2Br)C1.OB(O)c1cncnc1>>CC1(O)CCN(c2ccc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1,,CCO,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US06090833,BrBr.O=C1CCc2cc(-c3cccc(C(F)(F)F)c3)ccc21>>O=C1c2ccc(-c3cccc(C(F)(F)F)c3)cc2CC1Br,,CC(=O)O,O,Br,O=C([O-])O.[Na+],val
US06689909B1,CC(=O)Nc1c(Sc2ccc(F)cc2)ccc(N)c1Cl.C[C@@](O[Si](C)(C)C)(C(=O)Cl)C(F)(F)F>>CC(=O)Nc1c(Sc2ccc(F)cc2)ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c1Cl,,CCN(CC)CC,ClCCl,,,val
US20040235822A1,CCSc1nnc(CO)n1CC(C)C.ClC(Cl)Cl.O=S(Cl)Cl>>CCSc1nnc(CCl)n1CC(C)C.Cl,,O=S(Cl)Cl,,,,val
US20060089393A1,Cc1ccc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NNC(=O)OC(C)(C)C)cc1>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NN)cc1,,Cl,,,,val
US20100292212A1,CCOC(=O)C1(CCCOC)CCN(C(=O)OC(C)(C)C)CC1>>CCOC(=O)C1(CCCOC)CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060211719A1,CCOC(=O)N=NC(=O)OCC.O=C(NCCO)OCc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(NCCON1C(=O)c2ccccc2C1=O)OCc1ccccc1,,C1CCOC1,,CCOC(C)=O,,val
US06359134B1,O=CN1CCNCC1.O=S(=O)(Cl)c1ccc2ccccc2c1>>O=CN1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20050032824A1,CC=O.Nc1ccc2nc(S)sc2c1>>CCNc1ccc2nc(S)sc2c1,,C1CCOC1,O,CC(=O)O,[BH3-]C#N.[Na+],val
US20150057271A1,COCC(Cl)C(=O)Cl.COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc(N)c(O)c2)cc1>>COCC1Oc2cc(S(=O)(=O)N(Cc3ccc(OC)cc3)c3nccs3)ccc2NC1=O,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05310500,CCCCCCC(O)C(F)(F)F.ClCCl.O=C(Cl)c1ccc(-c2ccc(C(=O)Cl)cc2)cc1>>CCCCCCCCOC(=O)c1ccc2cc(O)ccc2c1,,ClCCl,,CCN(CC)CC,CN(C)C=O,val
US20100019663A1,Cc1ccccc1.O=[N+]([O-])c1cc(Br)ccc1Br.OB(O)c1cccc2ccccc12.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>O=[N+]([O-])c1cc(-c2cccc3ccccc23)ccc1-c1cccc2ccccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20080132557A1,O=C1CCC(=O)N1I.O=[N+]([O-])c1ccccc1-c1cccs1>>O=[N+]([O-])c1ccccc1-c1ccc(I)s1,,CO,,CC(=O)O,,val
US04231962,CC(C)C=NCc1cccc(Oc2ccccc2)c1.O>>O=Cc1cccc(Oc2ccccc2)c1,,Cc1ccccc1,,Cl,,val
US20090105258A1,C=Cc1cc(C(C)NC(=O)OC(C)(C)C)ccc1NS(C)(=O)=O.O=C(O)C(F)(F)F>>C=Cc1cc([C@@H](C)[NH3+])ccc1NS(C)(=O)=O.O=C([O-])C(F)(F)F,,ClCCl,,,,val
US20080275037A1,[N-]=[N+]=NC(CCO)c1ccc(C(F)(F)F)nc1>>NC(CCO)c1ccc(C(F)(F)F)nc1,[Pd],CCOC(C)=O,,,,val
US20040106616A1,CC(C)(C)Nc1ccccc1.CC(C)(C)c1ccc(Nc2nc(Cl)nc3nc(-c4ccccc4C(F)(F)F)ccc23)cc1>>CC(C)(C)c1ccc(Nc2nc(Cl)nc3nc(-c4ccccc4C(F)(F)F)ccc23)cc1.Nc1ccccc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US04994482,C=CCCCCCCCCC.O=S([O-])OO.c1ccc(-c2n[nH]c(-c3ccccc3)c2-c2ccccc2)cc1>>O=CCCCCCCCCCn1nc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1,,ClCCl,,CO,,val
US20110136801A1,CCOC(=O)COc1cccc(C=O)c1.NCCN1CCCCC1>>CCOC(=O)COc1cccc(CNCCN2CCCCC2)c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20120330012A1,C[Si](C)(C)CCOCn1ccc2c(C(O)C3CCCN(Cc4ccccc4)C3)ncnc21>>C[Si](C)(C)CCOCn1ccc2c(C(=O)C3CCCN(Cc4ccccc4)C3)ncnc21,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20100148229A1,C=CCCCCCC[Si](OC)(OC)OC>>CCCCCCC=C[Si](OC)(OC)OC,,O,,Cl,,val
US20110003787A1,COC(=O)c1ccc(F)c(F)c1.COC[C@H](C)Oc1cc(O)cc(-c2ccc(-c3nccs3)n2C(=O)OC(C)(C)C)c1>>COC[C@H](C)Oc1cc(Oc2ccc(C(=O)OC)cc2F)cc(-c2ccc(-c3nccs3)[nH]2)c1,,CS(C)=O,,O,[H-].[Na+],val
US20110207711A1,CCOC(=O)CC1CCCN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCCC1CC=O,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US20120094837A1,O=C(Cl)C(=O)Cl.O=C(O)c1cc(-c2cccnc2)on1>>O=C(Cl)c1cc(-c2cccnc2)on1,CN(C)C=O,ClCCl,,,,val
US20040138270A1,C1CCOC1.CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(CN)s1.O=C(n1ccnc1)n1ccnc1>>C#CCNC(=O)NCc1ccc(C(=O)Nc2ccccc2N)s1,,C1CCOC1,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20120115811A1,Cc1cc(C(=O)NC(C)C(N)=O)ccn1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>Cc1cc(-c2nc(C)c(N)s2)ccn1,,Cc1ccccc1,,,,val
US20150191452A1,CC(C)(C)[Si](C)(C)O[C@H]1CCNC1=O.FC(F)c1ccc(CBr)cc1>>CC(C)(C)[Si](C)(C)O[C@H]1CCN(Cc2ccc(C(F)F)cc2)C1=O,,C1CCOC1,,[H-].[Na+],,val
US20050124620A1,Cc1ccc(S(=O)(=O)n2cc(CCc3cccnc3)c3ccccc32)cc1>>c1cncc(CCc2c[nH]c3ccccc23)c1,,CO,,[K+].[OH-],,val
US03946043,Cc1cccc(C)c1N.ClCC1OCCCO1>>Cc1cccc(C)c1NCC1OCCCO1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050075342A1,CCOC(=O)CCCCC(C(C)=O)(C(=O)OC(C)(C)C)C(=O)c1cccc(C#N)c1>>CCOC(=O)CCCCC(C(C)=O)C(=O)c1cccc(C#N)c1,,O=C(O)C(F)(F)F,,,,val
US20070149562A1,NCCO.O=C1CCC2(CC1)OCCO2>>OCCNC1CCC2(CC1)OCCO2,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04272437,CCC(O)CC(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)Cl)cc1>>CCC(CC(=O)OC(C)(C)C)OS(=O)(=O)c1ccc(C)cc1,,c1ccncc1,,,,val
US20110230458A1,CCCCc1nnc(OCC2(F)CCN(C(=O)OC(C)(C)C)CC2)cc1-c1ccc(OC2CCCCC2)cc1.Cl.ClCCl>>CCCCc1nnc(OCC2(F)CCNCC2)cc1-c1ccc(OC2CCCCC2)cc1.Cl.Cl,,C1COCCO1,ClCCl,,,val
US20150119385A1,COC(OC)c1nc2c(cc1CN1CCN(C(=O)OCC[Si](C)(C)C)CC1=O)CCCN2.COCCNc1cc(N)ncc1C#N.O=C(n1cncn1)n1cncn1>>COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCN(C(=O)OCC[Si](C)(C)C)CC4=O)c(C(OC)OC)nc32)ncc1C#N,,CN(C)C=O,,,,val
US20120202287A1,C[C@H](O)[C@@H](CCc1ccccc1)n1cnc2c(N)ncnc21.Cl>>C[C@H](O)[C@@H](CCc1ccccc1)n1cnc2c(N)ncnc21.Cl,,CCOCC,,,,val
US20040082619A1,CCCCI.N#Cc1c2c(c[nH]c1=O)C(=O)CCC2>>CCCCn1cc2c(c(C#N)c1=O)CCCC2=O,,CN(C)C=O,,Cl,[H-].[Na+],val
US20040023964A1,FC(F)(F)c1cnn2c(-c3cccc(Br)c3)cnc2n1.OB(O)c1ccncc1>>FC(F)(F)c1cnn2c(-c3cccc(-c4ccncc4)c3)cnc2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US04048222,NCc1ccc(C(=O)O)cc1>>NC[C@@H]1CC[C@@H](C(=O)O)CC1,[Ru],[Na+],[OH-],,,val
US20090143381A1,O=C(O)c1cccc(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)cc3ccccc23)c1.O=S(Cl)Cl>>O=C(Cl)c1cccc(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)cc3ccccc23)c1,,ClCCl,,CN(C)C=O,,val
US20090069300A1,N#Cc1ccc(CBr)cc1.O=C1NCCc2cc(O)ccc21>>N#Cc1ccc(COc2ccc3c(c2)CCNC3=O)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04070373,N#CCC1c2ccccc2Oc2ccccc21>>NCCC1c2ccccc2Oc2ccccc21,O=[Pt],CC(=O)O,,O=S(=O)(O)O,,val
US05082943,CNc1ccccc1CSc1ncc[nH]1.O=C(OO)c1cccc(Cl)c1>>CNc1ccccc1CS(=O)c1ncc[nH]1,,CO,ClC(Cl)Cl,O=C([O-])O.[Na+],,val
US05665718,CCCCNCCCC.O=C1c2c(ccc(F)c2Cl)-n2cnc(-c3noc(CCl)n3)c2[C@@H]2CCN12>>CCCCN(CCCC)Cc1nc(-c2ncn3c2[C@@H]2CCN2C(=O)c2c-3ccc(F)c2Cl)no1,,CN(C)C=O,,,,val
US04469698,CC(C)n1c(=O)cc(Cl)[nH]c1=O.CCCCOS(=O)(=O)c1ccc(C)cc1>>CCCCn1c(Cl)cc(=O)n(C(C)C)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06156700,Cc1noc2cc(F)ccc12.O=[N+]([O-])O>>Cc1noc2cc(F)c([N+](=O)[O-])cc12,,O=S(=O)(O)O,,,,val
US05225402,COc1cc(OC(C)=O)ccc1C(=O)N1CCC(N2C(=O)CCc3ccccc32)CC1>>COc1cc(O)ccc1C(=O)N1CCC(N2C(=O)CCc3ccccc32)CC1,,CO,,[Na+].[OH-],,val
US20120258952A1,CC1(C)OCC(CO)O1.Nc1cc(Cl)ccn1>>CC1(C)OCC(COc2ccnc(N)c2)O1,,ClCCl,,O,[Na],val
US20060194797A1,CCI.CCOC(=O)C1CN(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4ccccc4)cc3)c2O1>>CCOC(=O)CCCN1CC(C(=O)OCC)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100112090A1,CC(C)(C)[Si](C)(C)OCCBr.O=C1c2ccccc2C(=O)N1c1cc(S(=O)(=O)N2CCCCc3ccccc32)c(O)cc1F>>CC(C)(C)[Si](C)(C)OCCOc1cc(F)c(N2C(=O)c3ccccc3C2=O)cc1S(=O)(=O)N1CCCCc2ccccc21,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04737513,C#CCn1ccc(C(=O)OC)c1C=O.NO>>C#CCn1ccc(C(=O)OC)c1C=NO,,c1ccncc1,,Cl,,val
US04048174,Nc1ccccc1N.O=C1CC=Cc2ncc3ccccc3c21>>c1ccc2c(c1)nc1c3ccccc3c3ccccc3n21,,O,,O=P(O)(O)O,,val
US20120122863A1,CCOC(=O)[C@H](c1ccc(Cl)cc1)n1c(=O)[nH]c2ccccc2c1=O.Cc1cc(C)c2c(CBr)nsc2c1>>CCOC(=O)[C@H](c1ccc(Cl)cc1)n1c(=O)c2ccccc2n(Cc2nsc3cc(C)cc(C)c23)c1=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06376666B1,CCCBr.Cc1cc2nc(S)[nH]c2cc1C>>CCCSc1nc2cc(C)c(C)cc2[nH]1,,CCCCCC,,CCOC(C)=O,[Na+].[OH-],val
US20120202785A1,C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)c(Br)c2n1C.OB(O)c1cccnc1>>C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)c(-c3cccnc3)c2n1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04492792,CCCCOC=C(C#N)C(OCCCC)OCCCC.CCCC[O-]>>CCCCOC(OCCCC)C(C#N)C(OCCCC)OCCCC,,CCCCO,,O=S(=O)(O)O,,val
US20110319378A1,CC[C@@H]([C@H](C)O)N1C(=O)[C@@](C)(CC(=O)OC)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1.CI>>CC[C@@H]([C@H](C)OC)N1C(=O)[C@@](C)(CC(=O)OC)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20090062271A1,COC(=O)c1ccc(OC)cc1OCCCNC(=O)OC(C)(C)C>>COc1ccc(C(=O)O)c(OCCCNC(=O)OC(C)(C)C)c1,,O,,C1CCOC1,,val
US20160221997A1,Brc1ccc2c(c1)OCCCNC2.CC(C)(C)OC(=O)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCCOc2cc(Br)ccc2C1,,ClCCl,,CCN(CC)CC,,val
US20100240642A1,COC(=O)c1ccc(-c2ccc(C)c(C=O)c2)cc1>>COC(=O)c1ccc(-c2ccc(C)c(CO)c2)cc1,,C1CCOC1,,[BH4-].[Na+],,val
US20050153959A1,Cc1cc(CC(N)c2nnc3ccccn23)cc2cn[nH]c12.O=C(c1ncc[nH]1)c1ncc[nH]1.O=C1Nc2c(F)cccc2CN1C1CCNCC1>>Cc1cc(CC(NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)c2nnc3ccccn23)cc2cn[nH]c12,,CN(C)C=O,,,,val
US20130131058A1,CSc1ncc2ccc(=O)n(C3CCCC3)c2n1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ncc2ccc(=O)n(C3CCCC3)c2n1,,ClCCl,,,,val
US20150152047A1,CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCOC3(C2)CN(C(c2ccccc2)c2ccccc2)C3)c(C(F)(F)F)c1>>CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCOC3(CNC3)C2)c(C(F)(F)F)c1,,ClCCl,,CC(Cl)OC(=O)Cl,,val
US20040053909A1,CN(C)CCN.COC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)C=C(C)[C@H](OC(N)=O)[C@@H](OC)C=CC=C(C)C(=O)NC(=CC1=O)C2=O.Cl>>CO[C@H]1C[C@H](C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)C(C)=C[C@H](C)[C@H]1O)C2=O.Cl,,C1COCCO1,ClCCl,,,val
US20090082464A1,CC(=O)O.CC(C)(CCCOC(=O)c1ccccc1)COS(=O)(=O)CCCN=[N+]=[N-]>>CC(=O)O.CC(C)(CCCOC(=O)c1ccccc1)COS(=O)(=O)CCCN,[Pd],CCO,,[H][H],,val
US20100069355A1,BrBr.CN(C)CCOc1c2[nH]c3ccc(F)cc3c2cc2c1[nH]c1ccc(F)cc12>>CN(C)CCOc1c2[nH]c3ccc(F)cc3c2c(Br)c2c1[nH]c1ccc(F)cc12,,CN(C)C=O,,ClCCl,,val
US20070259877A1,C[C@H]1CN(c2ccc(OCc3ccccc3)c(N)c2)C[C@@H](C)N1.O=S(=O)(Cl)c1ccc(Br)s1>>C[C@H]1CN(c2ccc(OCc3ccccc3)c(NS(=O)(=O)c3ccc(Br)s3)c2)C[C@@H](C)N1,,ClCCl,c1ccncc1,,,val
US05563141,Brc1cccc(Br)n1.O=C=O>>O=C(O)c1cccc(Br)n1,,CCCCCC,CCOCC,[Li]CCCC,,val
US04806549,COc1cccc2c(Cl)c(C(=O)c3ccccc3)cnc12.Cc1ccccc1N>>COc1cccc2c(Nc3ccccc3C)c(C(=O)c3ccccc3)cnc12,,C1COCCO1,,,,val
US20150259354A1,CC(=O)Nc1cccc(C(=O)/C=C/N(C)C)c1.N#Cc1c(-c2ccc(Oc3ccccc3)cc2)n[nH]c1N>>CC(=O)Nc1cccc(-c2ccnc3c(C#N)c(-c4ccc(Oc5ccccc5)cc4)nn23)c1,,CC(=O)O,,,,val
US20030153604A1,CNC.N#CCCCCBr>>CN(C)CCCCC#N,,[Na+],[OH-],,,val
US20070270422A1,CCOC1(O[Si](C)(C)C)CC1.O=C(CNc1ccc(O)cc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1>>O=C(CN(c1ccc(O)cc1)C1CC1)N1CCN(Cc2ccc3c(c2)OCO3)CC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20140242606A1,CC(C)=CC=O.NCc1ccccc1>>CC(C)=CC=NCc1ccccc1,,ClCCl,,,,val
US20120220565A1,O=C(O)C(F)(F)S(=O)(=O)F.O=S(=O)(c1ccc(N2CCOCC2)nc1)N1CCC2=Cc3c(cnn3-c3ccc(F)cc3)C[C@]2(CO)C1>>O=S(=O)(c1ccc(N2CCOCC2)nc1)N1CCC2=Cc3c(cnn3-c3ccc(F)cc3)C[C@]2(COC(F)F)C1,I[Cu]I,CC#N,,,,val
US20110288280A1,CC(=O)Oc1ccc(-c2cnc(N(S(=O)(=O)c3ccc([N+](=O)[O-])cc3)S(=O)(=O)c3ccc([N+](=O)[O-])cc3)c(Cc3ccccc3)n2)cc1>>O=[N+]([O-])c1ccc(S(=O)(=O)Nc2ncc(-c3ccc(O)cc3)nc2Cc2ccccc2)cc1,,CO,,[Na+].[OH-],,val
US20130137865A1,N#Cc1cccc(S(N)(=O)=O)c1.NO>>N=C(NO)c1cccc(S(N)(=O)=O)c1,,CCO,,,,val
US20150158863A1,CCC(Oc1ccc(C(F)(F)F)cc1)C(=O)OC>>CCC(Oc1ccc(C(F)(F)F)cc1)C(=O)O,,C1CCOC1,,[Na+].[OH-],,val
US20110245257A1,CC(NC(=O)OCc1ccccc1)c1cn2ccncc2n1.O=C1CCC(=O)N1I>>CC(NC(=O)OCc1ccccc1)c1nc2cnccn2c1I,,CC#N,O,,,val
US20020013460A1,CCN(CC)CC.OCC=Cc1ccc(Br)cn1>>CCOCC=Cc1ccc(Br)cn1,,C1CCOC1,,CS(=O)(=O)Cl,,val
US20100216827A1,Cc1snnc1-c1ccccc1.O=C1CCC(=O)N1Br>>BrCc1snnc1-c1ccccc1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US04353827,O=C1Nc2ccc(F)c(Cl)c2C1=O.OO>>O=c1[nH]c2ccc(F)c(Cl)c2c(=O)o1,,CC(=O)O,,O=S(=O)(O)O,,val
US20080004275A1,CCOC(=O)c1nc(N)cn1C.O=C=Nc1ccc(OC(F)(F)F)cc1>>CCOC(=O)c1nc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cn1C,,C1CCOC1,,,,val
US20110112151A1,O=C(CBr)C12CC3CC(CC(C3)C1)C2.OCc1ccc(C(F)(F)F)nc1>>O=C(COCc1ccc(C(F)(F)F)nc1)C12CC3CC(CC(C3)C1)C2,,C1CCOC1,,[H-].[Na+],,val
US20100190775A1,CSc1ncc2c(n1)N1CCC[C@H]1CN(c1cccc(C#N)c1)C2=O.NO>>CSc1ncc2c(n1)N1CCC[C@H]1CN(c1cccc(C(N)=NO)c1)C2=O,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20160221945A1,O=S(=O)(Cl)Cl.OCc1cc(Br)cc(I)c1>>ClCc1cc(Br)cc(I)c1,,O,,ClCCl,,val
US20140178360A1,CCOC=O.CCOCC(=O)OCC.NC(N)=O>>CCOc1cnc(O)nc1O,,CCO,Cc1ccccc1,C,C[O-].[Na+],val
US06693123B2,C=Cc1cnccc1Cl.COC(=O)[C@H](CCSC)NC(=O)c1ccc(I)cc1-c1ccccc1C>>COC(=O)[C@H](CCSC)NC(=O)c1ccc(C=Cc2cnccc2Cl)cc1-c1ccccc1C,,CN1CCCC1=O,,,,val
US20090076063A1,CI.Cc1[nH]c(=O)oc(=O)c1Cl>>Cc1c(Cl)c(=O)oc(=O)n1C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140171414A1,CNC.CS(=O)(=O)CCCBr>>CN(C)CCCS(C)(=O)=O,,CCOCC,,,,val
US20100075948A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.CCN(CC)CC.Nc1ccc(C(=O)[O-])s1>>COC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(c3ccc(Cl)cc3F)[C@H]2c2cccc(Cl)c2F)s1,CN(C)c1ccncc1,,,O=C(Cl)C(=O)Cl,,val
US20090105306A1,NNC(N)=S.O=C(O)C1(C(F)(F)F)CC1>>Nc1nnc(C2(C(F)(F)F)CC2)s1,,C1COCCO1,CCOC(C)=O,O=P(Cl)(Cl)Cl,,val
US20100179216A1,FC(F)(F)Oc1ccc(CCCBr)cc1.[SH-]>>FC(F)(F)Oc1ccc(CCCS)cc1,,CCO,,O,,val
US20110178120A1,COC(=O)c1ncc(CN(CCOCc2ccccc2)CCc2ccc(F)cc2)c2c1OC(C)(C)OC2>>COC(=O)c1ncc(CN(CCOCc2ccccc2)CCc2ccc(F)cc2)c(CO)c1O,,O=CO,,,,val
US20080269220A1,COC(=O)CCc1ccc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])cc1.OCc1ccc(CCl)cc1>>COC(=O)CCc1ccc(N(Cc2ccc(CCl)cc2)S(=O)(=O)c2ccccc2[N+](=O)[O-])cc1,,Cc1ccccc1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05854234,COC1=NCCCCC1C(C)(C)C.[Cl-].[NH4+]>>CC(C)(C)C1CCCCNC1=N.Cl,,CO,,,,val
US20130172353A1,NC(=O)c1c(-c2cccc(N)c2)nsc1N.O=C(Cl)c1cccc(C(F)(F)F)c1>>NC(=O)c1c(-c2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)nsc1N,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120225867A1,CC(=O)c1nc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3C)n2)cs1>>Cc1c(-c2ccn(C[C@H](C)NC(=O)c3csc(C(C)O)n3)n2)ccc(C#N)c1Cl,O,CCO,,[BH4-].[Na+],,val
US20120248969A1,CC(C)C(=O)Nc1ccc2c(c1)Cc1ccccc1-2.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)C(=S)Nc1ccc2c(c1)Cc1ccccc1-2,,Cc1ccccc1,,,,val
US20130172556A1,C=O.CCc1cc(C)cc(CC)c1C(=O)C(=O)NN>>C=NNC(=O)C(=O)c1c(CC)cc(C)cc1CC,,CO,,,,val
US20100029689A1,CCOc1cc(N(Cc2cccnc2)c2ccc(C(=O)OC(C)(C)C)cc2)ccc1OC(F)F>>CCOc1cc(N(Cc2cccnc2)c2ccc(C(=O)O)cc2)ccc1OC(F)F,,CCO,,[K+].[OH-],,val
US20150031730A1,[H]/N=C(C(=N\OCc1csc(NC(=O)OCCc2ccccc2)n1)/c1ccccc1)\N(O)CC>>CCn1oc(=O)nc1/C(=N\OCc1csc(N)n1)c1ccccc1,,CC#N,,O=C(n1ccnc1)n1ccnc1,,val
US20120208815A1,COc1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)c(N)c1.Nc1ncc(Br)nc1C(=O)O>>COc1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)c(NC(=O)c2nc(Br)cnc2N)c1,,CC#N,,,,val
US20110312945A1,CCOC(=O)Cn1c(C)c(Sc2ccc(S(=O)(=O)N3CCOCC3)cc2)c2c1CC(C)(C)CC2>>Cc1c(Sc2ccc(S(=O)(=O)N3CCOCC3)cc2)c2c(n1CC(=O)O)CC(C)(C)CC2,,C1CCOC1,O,[Na+].[OH-],,val
US05110799,C(=NC1CCCCC1)=NC1CCCCC1.O.O=C(O)[C@H](Cc1c[nH]cn1)Nc1ccc([N+](=O)[O-])cc1[N+](=O)[O-].OCc1ccccc1>>O=C(O)CN[C@@H](Cc1c[nH]cn1)C(=O)O,,ClCCl,,On1nnc2ccccc21,,val
US20050227997A1,CNC(=O)N1CCN(S(=O)(=O)c2ccc(O)cc2)C(C23OCC(C)(CO2)CO3)C1C.Cc1ccc(F)cc1CBr>>CNC(=O)N1CCN(S(=O)(=O)c2ccc(OCc3cc(F)ccc3C)cc2)C(C23OCC(C)(CO2)CO3)C1C,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070207994A1,Cc1ccc(C(=O)Cl)cc1F.Cn1ncc(Cl)c1-c1cc(N)ccc1OCCN1CCOCC1>>Cc1ccc(C(=O)Nc2ccc(OCCN3CCOCC3)c(-c3c(Cl)cnn3C)c2)cc1F,,ClCCl,,CCN(CC)CC,,val
US20130116277A1,COc1ccc2c(=O)n(-c3ccc(C=O)c(OC)c3)cc(-c3ccc(C(F)(F)F)cc3)c2c1>>COc1ccc2c(=O)n(-c3ccc(CO)c(OC)c3)cc(-c3ccc(C(F)(F)F)cc3)c2c1,,CCO,,[BH4-].[Na+],,val
US04347315,Cln1cnc2cnccc21.NCc1ccccc1>>c1ccc(CNc2nccc3[nH]cnc23)cc1,O,O,,,,val
US04708955,CC(C)(C)C(=O)OCI.CC=CC1=C(C(=O)O)N2C(=O)C(NC(=O)/C(=N\OC)c3csc(N)n3)[C@H]2SC1>>C/C=C\C1=C(C(=O)OCOC(=O)C(C)(C)C)N2C(=O)C(NC(=O)/C(=N\OC)c3csc(N)n3)[C@H]2SC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20140179715A1,CN1CCn2c1cc(Cl)nc2=O.N#Cc1cc(CO)ccc1Oc1cncc(F)c1>>CN1CCn2c1cc(OCc1ccc(Oc3cncc(F)c3)c(C#N)c1)nc2=O,,C1CCOC1,,[H-].[Na+],,val
US20110311474A1,Cc1ccc(S(=O)(=O)n2ccc3c2ncc2nnc(C45CCC(N)(CC4)CC5)n23)cc1.O=S(=O)(Cl)N1CCCC1>>Cc1ccc(S(=O)(=O)n2ccc3c2ncc2nnc(C45CCC(NS(=O)(=O)N6CCCC6)(CC4)CC5)n23)cc1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,O=C([O-])[O-].[K+].[K+],val
US20030023104A1,CCCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC.NC(CO)(CO)CO.NCC(=O)O.O=C(O)CCCc1ccc(N(CCCl)CCCl)cc1>>CCCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC.NC(CO)(CO)CO.NCC(=O)O.O=C(O)CCCc1ccc(N(CCCl)CCCl)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05702637,CCCCCCO.CCOC(CBr)OCC>>CCCCCCOCC(OCC)OCC,,Cc1ccccc1,,[H-].[Na+],,val
US20080193411A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=C(Nc1ccc(Br)cc1)C1CC1>>CC1(C)OB(c2ccc(NC(=O)C3CC3)cc2)OC1(C)C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CS(C)=O,,CC(=O)[O-].[K+],,val
US20080021022A1,Cc1ccc(-c2oncc2C(=O)Cl)cc1.c1ccc2c(c1)CNC2>>Cc1ccc(-c2oncc2C(=O)N2Cc3ccccc3C2)cc1,,ClCCl,,,,val
US20150165026A1,C#CC(=O)Oc1ccc(-c2ccccc2)cc1.CCNCC>>CCN(C=CC(=O)Oc1ccc(-c2ccccc2)cc1)CC,,C1CCOC1,,,,val
US08815877B2,CC(C)(C)OC(=O)NCc1nc2ccn(COCC[Si](C)(C)C)c2cc1F.CI>>CN(Cc1nc2ccn(COCC[Si](C)(C)C)c2cc1F)C(=O)OC(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20080161278A1,CC(=O)c1nccs1.NC1CCCCC1>>CC(=NC1CCCCC1)c1nccs1,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,,,val
US20070244155A1,C=C1CCOc2cc(OCc3ccccc3)ccc2C1CC(=O)OCC>>C=C1CCOc2cc(OCc3ccccc3)ccc2C1CC(=O)O,,C1CCOC1,,CO,[Li+].[OH-],val
US04806663,CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1>>CCCCc1oc2ccccc2c1C(O)c1ccc(OCCN(CC)CC)cc1,Cl[Pd]Cl,CO,,[BH4-].[Na+],,val
US20100292188A1,CC(=O)N1CCC(=O)C(Br)C1.NC(=S)c1ccc(O)cc1>>CC(=O)N1CCc2nc(-c3ccc(O)cc3)sc2C1,,CC(C)O,,,,val
US05876984,C[C@H]1CC[C@H]2C(C)(C)C(=O)CC[C@]23Oc2c(c(OP(=O)(OC(C)(C)C)OC(C)(C)C)cc4c2CNC4=O)C[C@]13C.NO>>C[C@H]1CC[C@H]2C(C)(C)C(=NO)CC[C@]23Oc2c(c(OP(=O)(OC(C)(C)C)OC(C)(C)C)cc4c2CNC4=O)C[C@]13C,,CCO,,Cl,c1ccncc1,val
US05236912,C[C@]1(O)C[C@]2(C)C(=O)CC[C@H]2[C@@H]2CCC3=CC(=O)CC[C@]3(C)[C@H]21>>C=C1C[C@]2(C)C(=O)CC[C@H]2[C@@H]2CCC3=CC(=O)CC[C@]3(C)[C@@H]12,,O=CO,,[Na+].[OH-],,val
US20090264440A1,COCCN.NC(=O)C1(C(=O)N(c2ccccc2)c2ccc(Oc3ccnc4cc(-c5ccc(C=O)cn5)sc34)c(F)c2)CC1>>COCCNCc1ccc(-c2cc3nccc(Oc4ccc(N(C(=O)C5(C(N)=O)CC5)c5ccccc5)cc4F)c3s2)nc1,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05436229,CC(C)(C)OC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccccc1,[Pd],CCO,,,,val
US20130109854A1,C=CC1CN(CC)C(=O)C1(c1ccccc1)c1ccccc1.OO>>CCN1CC(CCO)C(c2ccccc2)(c2ccccc2)C1=O,,C1CCOC1,,[Na+].[OH-],[Cl-].[NH4+],val
US20150111885A1,CC(C)n1cc(B2OC(C)(C)C(C)(C)O2)cn1.OO>>CC(C)n1cc(O)cn1,,C1CCOC1,,[Na+].[OH-],,val
US06498251B1,C=CCn1c2c(c3ccccc31)CCN(C(=O)OC(C)(C)C)C2.O=C(O)C(F)(F)F>>C=CCn1c2c(c3ccccc31)CCNC2.O=C([O-])C(F)(F)F,,ClCCl,,COc1ccccc1,,val
US07381719B2,CC(C)CCCN.COc1cc(C=O)ccc1Oc1ccc(C(N)=O)cn1>>COc1cc(CNCCCC(C)C)ccc1Oc1ccc(C(N)=O)cn1,,CO,,[BH4-].[Na+],,val
US20160214978A1,Cc1ccc(NC=O)cc1.Cc1nc2ccccc2n1-c1cc(Cl)nc(S(C)(=O)=O)n1>>Cc1ccc(N(C=O)c2nc(Cl)cc(-n3c(C)nc4ccccc43)n2)cc1,,C1COCCO1,,O,[H-].[Na+],val
US20160102107A1,Cc1nnc2c(NC(=O)OC(C)(C)C)cc(N3C(=O)c4c(C5CC5)nn(C)c4C3c3ccc(Cl)cc3)cn12>>Cc1nnc2c(N)cc(N3C(=O)c4c(C5CC5)nn(C)c4C3c3ccc(Cl)cc3)cn12,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20080027093A1,C[C@@H](c1ccc(O)cc1)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CC[C@H](F)C1>>C[C@@H](C1CCC(O)CC1)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CC[C@H](F)C1,[Rh],CO,,[H][H],,val
US20120232237A1,Nc1c(N)c(-c2cccs2)c(F)c(F)c1-c1cccs1.O=S=Nc1ccccc1>>Fc1c(F)c(-c2cccs2)c2nsnc2c1-c1cccs1,,c1ccncc1,,C[Si](C)(C)Cl,,val
US20030105094A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[Si](C)(C)CCOC(=O)N1CCC(C(CN=[N+]=[N-])c2ccc(Br)cc2)CC1>>CC(C)(C)OC(=O)NCC(c1ccc(Br)cc1)C1CCN(C(=O)OCC[Si](C)(C)C)CC1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06599890B1,C=CCBr.COC(=O)CC[C@@H](NC(=O)OCc1ccccc1)C(=O)OC(C)(C)C>>C=CC[C@H](C[C@@H](NC(=O)OCc1ccccc1)C(=O)OC(C)(C)C)C(=O)OC,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20160031871A1,CC(=O)Nc1ncc(CCl)s1.c1cc2c(cc1CC1CCNCC1)OCO2>>CC(=O)Nc1ncc(CN2CCC(Cc3ccc4c(c3)OCO4)CC2)s1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20110118245A1,COc1cc2ncnc(Sc3cccc(N)c3)c2cc1OC.Cn1nc(NC(=O)Oc2ccccc2)cc1C(F)(F)F>>COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(C(F)(F)F)n(C)n4)c3)c2cc1OC,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080214553A1,COc1ccc(CN(CCCN2CCCCC2)c2ccc3nc(-c4cccc(OC)c4)n(CC(=O)NC(C)C)c(=O)c3c2)cc1>>COc1cccc(-c2nc3ccc(NCCCN4CCCCC4)cc3c(=O)n2CC(=O)NC(C)C)c1,[Pd],CCO,,,,val
US04740513,Cc1cc(-n2ccnc2C)cc2ccc(=O)[nH]c12.O=C1CCC(=O)N1Cl>>Cc1cc(-n2c(Cl)cnc2C)cc2ccc(=O)[nH]c12,,ClCCl,,,,val
US20110070192A1,O=c1ccn([C@@H]2CO[C@@H]3COC(c4ccccc4)O[C@H]3[C@H]2O)c(=O)[nH]1>>O=c1ccn([C@@H]2CO[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1,,CCOC(C)=O,CO,Cl,,val
US20090156607A1,Clc1ccc2[nH]ccc2c1.Fc1ncccc1CCl>>Fc1ncccc1Cn1ccc2cc(Cl)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20110257100A1,CN1CCNCC1.O=CCn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)c1>>CN1CCN(CCn2cnc(-c3cc4nccc(Oc5ccc(NC(=O)NC6CC6)cc5F)c4s3)c2)CC1,,CN1CCCC1=O,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20070219186A1,C1CCNC1.O=C(CCl)Nc1cc(C(=O)Nc2cccc(-c3ccnc4cc(-c5ccncc5)nn34)c2)cc(C(F)(F)F)c1>>O=C(CN1CCCC1)Nc1cc(C(=O)Nc2cccc(-c3ccnc4cc(-c5ccncc5)nn34)c2)cc(C(F)(F)F)c1,,CN(C)C=O,,CCN(CC)CC,,val
US20140179666A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc2ccc(Br)cc21.O=S(=O)(F)c1ccccc1>>CC(C)[Si](C(C)C)(C(C)C)n1ccc2ccc(S(=O)(=O)c3ccccc3)cc21,,C1CCOC1,,CCCCC,[Li]C(C)(C)C,val
US04436748,CCOC(=O)CBr.Oc1cc2cc(C3CCCCC3)sc2c(Cl)c1Cl>>CCOC(=O)COc1cc2cc(C3CCCCC3)sc2c(Cl)c1Cl,,CCC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150322073A1,COC(=O)c1cc(C)c(=O)n(C)c1>>Cc1cc(C(=O)O)cn(C)c1=O,,CO,,[Na+].[OH-],,val
US20040044012A1,CCN1C(=O)N(c2cc(OC)cc(OC)c2)Cc2cnc(SC)nc21.O=S(=O)(c1ccccc1)N1OC1c1ccccc1>>CCN1C(=O)N(c2cc(OC)cc(OC)c2)Cc2cnc(S(C)=O)nc21,,ClCCl,,,,val
US20090012082A1,O=C(Nc1cc(Cl)ccc1[N+](=O)[O-])c1cc([N+](=O)[O-])ccc1Cl>>Nc1ccc(Cl)c(-c2nc3cc(Cl)ccc3[nH]2)c1,[Zn],CC(=O)O,,,,val
US20080146565A1,CCC(C)(N)O.O=C(O)[C@@H]1CC[C@@H](Nc2nccc(-n3ncc4ccccc43)n2)CC1>>CC(O)CCNC(=O)[C@@H]1CC[C@@H](Nc2nccc(-n3ncc4ccccc43)n2)CC1,,C1CCOC1,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20100081674A1,CC(=O)OCCBr.O=Cc1c(O)ccc(F)c1F>>CC(=O)OCCOc1ccc(F)c(F)c1C=O,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20140243286A1,COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCN)c1nnc(C)n1-2.O=C(O)c1cccc(B(O)O)c1>>COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCNC(=O)c1cccc(B(O)O)c1)c1nnc(C)n1-2,CN(C)c1ccncc1,CN(C)C=O,ClCCl,CCN=C=NCCCN(C)C,,val
US20050282863A1,CCCCN(C)CCCCCn1c2c(c3ccccc31)CCSc1ccccc1-2.O=C(O)/C=C/C(=O)O>>CCCCN(C)CCCCCn1c2c(c3ccccc31)CCSc1ccccc1-2.O=C(O)/C=C/C(=O)O,,CCO,,,,val
US20120172599A1,CC1=C(C#N)C(=C(C#N)C#N)OC1(c1ccccc1)C(F)(F)F.CCCCN(CCCCO)c1ccc(C=Cc2ccc(C=O)s2)c(OCc2ccccc2)c1>>CCCCN(CCCCO)c1ccc(C=Cc2ccc(C=CC3=C(C#N)C(=C(C#N)C#N)OC3(c3ccccc3)C(F)(F)F)s2)c(OCc2ccccc2)c1,,CCO,,,,val
US20120184548A1,NCc1ccccc1.O=C(Cl)c1ccc(Cl)c([N+](=O)[O-])c1>>NC(=O)c1ccc(Cl)c([N+](=O)[O-])c1Cc1ccccc1,CN(C)c1ccncc1,CCOCC,O,CCN(CC)CC,,val
US20040142979A1,CC(C)(C)OC(=O)C1(S(=O)(=O)c2ccc(-c3ccc(OC(F)(F)C(F)F)cc3)s2)CCOCC1>>O=C(O)C1(S(=O)(=O)c2ccc(-c3ccc(OC(F)(F)C(F)F)cc3)s2)CCOCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04940710,CCn1cc(C(=O)O)c(=O)c2cc(F)c(Cl)cc21.Cc1csc(C2CNCCN2)c1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(c4cc(C)cs4)C3)cc21,,c1ccncc1,,,,val
US20090181963A1,CN(C)CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3nnn(C4CCNCC4)c3n2)cc1.O=Cc1cccnc1>>CN(C)CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3nnn(C4CCN(Cc5cccnc5)CC4)c3n2)cc1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040116465A1,CCOc1ccc(CC(=O)Nc2cc(N(C)C(=O)CC(C)C)ccc2[N+](=O)[O-])cc1>>CCOc1ccc(CC(=O)Nc2cc(N(C)C(=O)CC(C)C)ccc2N)cc1,[Pd],CCOC(C)=O,,,,val
US20130231333A1,CCOC(=O)/C=C/c1ccc(/C(=C(/CC)c2ccc(Br)cc2)c2ccc3c(cnn3C3CCCCO3)c2)cc1.OB(O)c1cncnc1>>CCOC(=O)/C=C/c1ccc(/C(=C(/CC)c2ccc(-c3cncnc3)cc2)c2ccc3c(cnn3C3CCCCO3)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20150239879A1,CC(C)(C)C=O.c1ccc(-c2ccc3nc(Cc4nnc(C5CNC5)o4)sc3c2)cc1>>CC(C)(C)CN1CC(c2nnc(Cc3nc4ccc(-c5ccccc5)cc4s3)o2)C1,CC(=O)O,ClCCl,ClCCl,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20070149508A1,COc1ccc(F)c(CBr)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(F)c(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1.[Br-],,Cc1ccccc1,,,,val
US09428452B2,Cc1ccc(N(CC(C)C)S(=O)(=O)c2ccc(OCC3CCOCC3)cc2Cl)c(C)c1.N#C[Cu]>>Cc1ccc(N(CC(C)C)S(=O)(=O)c2ccc(OCC3CCOCC3)cc2C#N)c(C)c1,,CN1CCCC1=O,,,,val
US04997942,CCCCCCCc1ccc(-c2cnc(-c3ccc(OC)c(F)c3)nc2)cc1>>CCCCCCCc1ccc(-c2cnc(-c3ccc(O)c(F)c3)nc2)cc1,,Br,CC(=O)O,O,,val
US06133284,CCOC(=O)c1cn(-c2nc(NCc3ccc(OC)cc3)c(F)cc2F)c2c(C)c(F)c(F)c(N)c2c1=O>>Cc1c(F)c(F)c(N)c2c(=O)c(C(=O)O)cn(-c3nc(N)c(F)cc3F)c12,,Cl,,,,val
US20080262042A1,CC(Br)C(=O)c1cccnc1F.CCOC(=O)CC#N>>CCOC(=O)C(C#N)C(C)C(=O)c1cccnc1F,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20130102621A1,CC(C)(C)OC(=O)N1CCC(c2coc3c(Nc4ccc(S(C)(=O)=O)cc4F)ncnc23)CC1.Cl>>CS(=O)(=O)c1ccc(Nc2ncnc3c(C4CCNCC4)coc23)c(F)c1.Cl,,CCOC(C)=O,,,,val
US20110263595A1,CCOc1ncnc2[nH]ccc12.O=C1CCC(=O)N1I>>CCOc1ncnc2[nH]cc(I)c12,,ClCCl,,CN(C)C=O,O,val
US20070173530A1,Nc1ccc2cnccc2c1Cl.O=C(O)CCl>>O=C(CCl)Nc1ccc2cnccc2c1Cl,CN(C)c1ccncc1,CN(C)C=O,,ClCCCl,,val
US04769480,CCOC(CBr)OCC.COc1c(CNS(=O)(=O)c2ccc(C)cc2)ccc2c1OCO2>>CCOC(CN(Cc1ccc2c(c1OC)OCO2)S(=O)(=O)c1ccc(C)cc1)OCC,,O,,CN(C)C=O,,val
US06197960B1,CCOC(=O)C1CNC(=O)CC1c1ccc(F)cc1>>CCOC(=O)[C@@H]1CNC(=O)C[C@H]1c1ccc(F)cc1,,Cc1ccccc1,,C,C[O-].[Na+],val
US20060287522A1,COC(=O)c1ccc(C(=O)N2Cc3ccc(C(=O)NCc4cccnc4)n3Cc3ccccc32)cc1>>O=C(O)c1ccc(C(=O)N2Cc3ccc(C(=O)NCc4cccnc4)n3Cc3ccccc32)cc1,,CO,O,[Li+].[OH-],,val
US04477671,CC(C)(C)NCC(O)c1ccc(O)c(CO)[n+]1[O-].Cl.Cl>>Cc1nc(C(O)CNC(C)(C)C)ccc1O.Cl.Cl,[Pd],CO,,,,val
US20130150339A1,COc1ccc(CNc2nccs2)cc1.O=S(=O)(Oc1c(F)c(F)c(F)c(F)c1F)c1ccc2c(Cl)nccc2c1>>COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(Cl)nccc3c2)cc1,,,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20160168100A1,COc1cc(C)c(C=CC(=O)O)cc1OCc1ccccc1.COc1ccc(CCN)cc1OCc1ccccc1>>COc1ccc(CCNC(=O)/C=C/c2cc(OCc3ccccc3)c(OC)cc2C)cc1OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080293718A1,COc1cc(O)cc(-c2cccc(C3(c4ccncc4)NC(=S)N(C)C3=O)c2)c1.CS(=O)(=O)Cl>>COc1cc(OS(C)(=O)=O)cc(-c2cccc(C3(c4ccncc4)NC(=S)N(C)C3=O)c2)c1,,ClCCl,,CCN(CC)CC,O,val
US20110009429A1,CCOC(=O)CC(=O)CCc1ccccc1F.Cc1cc(N)n[nH]1>>Cc1cc2nc(CCc3ccccc3F)cc(O)n2n1,,CC(=O)O,,O,,val
US20070105943A1,O=C1c2ccccc2C(=O)N1Cc1ccc(COc2ccccc2)cn1>>NCc1ccc(COc2ccccc2)cn1,,C1CCOC1,CCO,NN,O,val
US20070259965A1,NCC(O)CN.O=S(=O)(Cl)c1ccc(Cl)cc1Cl>>NCC(O)CNS(=O)(=O)c1ccc(Cl)cc1Cl,,ClCCl,,CCN(CC)CC,,val
US05073641,CN(C)C(=O)CCl.O=C(O)c1ccccc1>>CN(C)C(=O)COC(=O)c1ccccc1,,CN(C)C=O,O,CCN(CC)CC,[I-].[Na+],val
US06437146B1,CNCCc1ccccn1.O=C(O)c1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1>>CN(CCc1ccccn1)C(=O)c1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1,,CCOC(C)=O,CN(C)C=O,CCN=C=NCCCN(C)C,Cl,val
US20110070317A1,CC(C)(C)OC(=O)N[C@@H]1CCCNC1.CC(C)CC(=O)Nc1c[nH]c2ncc(Br)c(F)c12>>CC(C)CC(=O)Nc1c[nH]c2ncc(Br)c(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)c12,,CCCCO,,CCN(CC)CC,,val
US20160237043A1,C=CCN(CCC[C@H](N)C(=O)O)C1C[C@H]1c1ccc(F)cc1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=CCN(CCC[C@H](NC(=O)OC(C)(C)C)C(=O)O)C1C[C@H]1c1ccc(F)cc1,,C1COCCO1,O,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20120142677A1,CN(C(=O)OC(C)(C)C)c1ccc(N2C(=O)CC[C@H]2C(=O)Nc2cc(C(C)(C)C)on2)cc1>>CNc1ccc(N2C(=O)CC[C@H]2C(=O)Nc2cc(C(C)(C)C)on2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05559141,CC(C)(C)NC(=O)c1ccc(C(O)(CCc2c[nH]cn2)c2ccccc2)cc1>>CC(C)(C)NC(=O)c1ccc(C(=CCc2c[nH]cn2)c2ccccc2)cc1,,ClCCl,,O=S(Cl)Cl,,val
US04772600,CCCNCCC.O=C(O)Cn1c(-c2ccc(C(F)(F)F)cc2)nc2cccnc21>>CCCN(CCC)C(=O)Cn1c(-c2ccc(C(F)(F)F)cc2)nc2cccnc21,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20150057238A1,N=C(NO)[C@H]1C[C@@H]1C(=O)c1ccc(F)c(Cl)c1.O=C(c1ncc[nH]1)c1ncc[nH]1>>O=C(c1ccc(F)c(Cl)c1)[C@H]1C[C@@H]1c1nc(=O)o[nH]1,,C1COCCO1,,C1CCC2=NCCCN2CC1,,val
US20080085890A1,CCCC[Sn](CCCC)(CCCC)c1ccco1.O=C1NC(=O)c2ccc(Br)cc2C1=CNc1ccc(CN2CCCC2CO)cc1>>O=C1NC(=O)c2ccc(-c3ccco3)cc2C1=CNc1ccc(CN2CCCC2CO)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US05480899,COC(=O)CCc1ccc(OCC2CN(c3ccc(Cl)cc3)C(=O)O2)cc1>>O=C1OC(COc2ccc(CCCO)cc2)CN1c1ccc(Cl)cc1,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20040019048A1,CCCCc1nc2c(N)nc3ccccc3c2n1CCCN.S=C=Nc1ccccc1>>CCCCc1nc2c(N)nc3ccccc3c2n1CCCNC(=S)Nc1ccccc1,,CN1CCCC1=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160009744A1,Cc1cc(C(=O)OCCCl)n[nH]1>>Cc1cc2n(n1)CCOC2=O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120252807A1,NCCc1ccccn1.O=C(O)C1CCN(C(=O)c2cccn2Cc2ccc(Cl)cc2)CC1>>O=C(NCCc1ccncc1)C1CCN(C(=O)c2cccn2Cc2ccc(Cl)cc2)CC1,,CCOC(C)=O,ClCCl,ClCCCl,On1nnc2ccccc21,val
US04859661,CC(C)c1ccc(O)cc1.O=[N+]([O-])O>>CC(C)c1ccc(O)c([N+](=O)[O-])c1,,O,,,,val
US20110118230A1,BrBr.COC(=O)c1cc2c(cn1)[nH]c1ncccc12>>COC(=O)c1cc2c(cn1)[nH]c1ncc(Br)cc12,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20140005146A1,C=Cc1cccc(-c2cc3c(N[C@H](C)C4CC4)c(C(N)=O)cnn3c2)c1.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>CC(Nc1c(C(N)=O)cnn2cc(-c3cccc([C@@H](O)CO)c3)cc12)C1CC1,O=[Os](=O)(=O)=O,,,C1CCOC1,O,val
US20130203818A1,Cc1nc2cc(Cl)c(-c3ccc(N)cc3)cc2o1.O=C(Cl)c1ccccc1F>>Cc1nc2cc(Cl)c(-c3ccc(NC(=O)c4ccccc4F)cc3)cc2o1,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US05366988,CC(C)(C)CO.CC(C)ON=C(c1cccc(O)c1)n1cncn1>>CC(C)CCc1cccc(C(=NOC(C)C)n2cncn2)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05192766,COc1ccc(/C(=C/C(=O)N2CCN(C(=O)c3cc(OC)c(OC(C)=O)c(OC)c3)CC2)c2ccccc2Cl)cc1>>COc1ccc(/C(=C/C(=O)N2CCN(C(=O)c3cc(OC)c(O)c(OC)c3)CC2)c2ccccc2Cl)cc1,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US20160200681A1,CC(C)(C)OC(=O)N1Cc2c[nH]cc2C1=O.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1Cc2c(c[nH]c2Br)C1=O,,C1CCOC1,,O,,val
US20160002269A1,BrCc1ccccc1.COC(=O)c1ccc([N+](=O)[O-])cc1O>>COC(=O)c1ccc([N+](=O)[O-])cc1OCc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120022082A1,COCCCN.CS(=O)(=O)OCCCc1ccc(Br)cc1>>COCCCNCCCc1ccc(Br)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160221945A1,COc1nn(-c2cnc(C(F)(F)F)nc2)cc1C(=O)O.[NH4+]>>COc1nn(-c2cnc(C(F)(F)F)nc2)cc1C(N)=O,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05574042,Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)C(F)(F)F)c3Cl)cccn2c1Br>>CNc1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl,,CO,,C[O-].[Na+],,val
US20150011530A1,C=CC(=O)Cl.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCC2(CC1)CNC2>>C=CC(=O)N1CC2(CCC(n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)C1,,ClCCl,,CCN(CC)CC,,val
US20130137708A1,CC(C)n1nc(-c2cccc(N)c2)c2c(N)ncnc21.O=C(Cl)CCl>>CC(C)n1nc(-c2cccc(NC(=O)CCl)c2)c2c(N)ncnc21,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20070265228A1,COS(=O)(=O)OC.Cc1cc(O)c(C(=O)C=Cc2cccc(C=CC#N)c2)c(=O)o1>>COc1cc(C)oc(=O)c1C(=O)C=Cc1cccc(C=CC#N)c1,,CN(C)P(=O)(N(C)C)N(C)C,,[H-].[Na+],,val
US04036989,CCc1ccc(I)cc1.O=[N+]([O-])c1ccccc1.O=[N+]([O-])c1ccccc1Br>>CCc1ccc(-c2ccccc2)c([N+](=O)[O-])c1,[Cu],ClCCl,,,,val
US20110230458A1,CC(C)(C)OC(=O)N1CCC(F)(CO)CC1.CCCCc1nnc(Cl)cc1-c1ccc(OC2CCCCC2)cc1>>CCCCc1nnc(OCC2(F)CCN(C(=O)OC(C)(C)C)CC2)cc1-c1ccc(OC2CCCCC2)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20140073650A1,CC(C)(C)OC(=O)CBr.CCCc1ccc(O)cc1>>CCCc1ccc(OCC(=O)OC(C)(C)C)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20130231342A1,CCOC(=O)c1ncc(NC(=O)OC(C)(C)C)s1>>CC(C)(C)OC(=O)Nc1cnc(CO)s1,,CO,,[BH4-].[Na+],,val
US20090270435A1,COC(=O)c1cc(C(=O)C=CN(C)C)ccc1F.NN>>COC(=O)c1cc(-c2cc[nH]n2)ccc1F,,CO,,O,,val
US04535089,CCOC(=O)CC(NC(=O)c1ccc(F)cc1)C(=O)CC(C)C>>CCOC(=O)Cc1nc(-c2ccc(F)cc2)oc1CC(C)C,,CN(C)C=O,,O=P(Cl)(Cl)Cl,,val
US20090209586A1,COc1ccc(CCCl)cc1.Nc1ccccc1N1CCCCC1>>COc1ccc(CCNc2ccccc2N2CCCCC2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100152163A1,Cc1ccc2[nH]c3c(c2c1)CCN(C)CC3.O=C(CCl)N1CCOCC1>>Cc1ccc2c(c1)c1c(n2CC(=O)N2CCOCC2)CCN(C)CC1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20030229053A1,C#CCBr.COC(=O)C(Cc1ccccc1)NS(=O)(=O)c1c(C)cc(OC)c(C)c1C>>C#CCN(C(Cc1ccccc1)C(=O)OC)S(=O)(=O)c1c(C)cc(OC)c(C)c1C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120053180A1,CS(=O)(=O)Cl.OC1CCC(OCc2ccccc2)CC1>>CS(=O)(=O)OC1CCC(OCc2ccccc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20100173901A1,CC1(C)OB(c2cnn(CC3(C#N)CC3)c2)OC1(C)C.CC1Cc2ccc(Br)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1>>CC1Cc2ccc(-c3cnn(CC4(C#N)CC4)c3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,O,C1COCCO1,O=C([O-])O.[Na+],val
US20140350019A1,CCOC(=O)CBr.Oc1ccc(F)c(NCc2c(F)ccc(-c3cccc(F)c3)c2F)c1F>>CCOC(=O)COc1ccc(F)c(NCc2c(F)ccc(-c3cccc(F)c3)c2F)c1F,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04207317,COc1ccc(N2N=C(C)CC2=O)cc1.O=C=Nc1ccc(Cl)c(Cl)c1>>COc1ccc(N2N=C(C)C(C(=O)Nc3ccc(Cl)c(Cl)c3)C2=O)cc1,,c1ccccc1,,CCN(CC)CC,,val
US20130261125A1,CC(C)(C)OC(=O)N1CCCC(CO)(Cc2ccccc2F)C1>>OCC1(Cc2ccccc2F)CCCNC1,,C1COCCO1,,Cl,,val
US20150080393A1,CCOC(=O)[C@@H]1CC2(CCN(c3cc(COc4ccc(-c5ccc6c(C)n[nH]c6c5)cc4)nc(N)n3)CC2)CN1C(=O)OC(C)(C)C>>CCOC(=O)[C@@H]1CC2(CCN(c3cc(COc4ccc(-c5ccc6c(C)n[nH]c6c5)cc4)nc(N)n3)CC2)CN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040014776A1,CC(=O)OC(C)=O.NCCn1cncc1-c1ccnc(Nc2cccc(Cl)c2)n1>>CC(=O)NCCn1cncc1-c1ccnc(Nc2cccc(Cl)c2)n1,,CCOC(C)=O,c1ccncc1,N,,val
US20120108574A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccc(NC(=O)C5CC5)cc4)nc4n3-c3cccnc3Nc3ccccc3-4)cc2)CCC1.Cl.ClCCl>>Cl.Cl.Cl.NC1(c2ccc(-c3c(-c4ccc(NC(=O)C5CC5)cc4)nc4n3-c3cccnc3Nc3ccccc3-4)cc2)CCC1,,ClCCl,,C1COCCO1,,val
US20130116243A1,CCN1C(=O)COc2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc21>>CCN1C(=O)COc2nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)cc21,,O=C(O)C(F)(F)F,,,,val
US20060252811A1,O=S(Cl)Cl.OCc1nccn1Cc1cc(Cl)cc(Cl)c1>>Cl.ClCc1nccn1Cc1cc(Cl)cc(Cl)c1,,ClC(Cl)Cl,,,,val
US20030114679A1,CCOC(C)=O.NC1CCc2cccnc21>>CC(=O)N[C@@H]1CCc2cccnc21,,CO,ClCCl,[NH4+].[OH-],,val
US06043252,O=Cc1ccc(/C=C/C(=O)N2CCc3c([nH]c4ccccc34)C2c2ccc3c(c2)OCO3)cc1>>O=C(/C=C/c1ccc(CO)cc1)N1CCc2c([nH]c3ccccc23)C1c1ccc2c(c1)OCO2,,CO,ClCCl,[BH4-].[Na+],,val
US20150210722A1,CC(C)(C)c1cc(N)n(-c2cccc(P(C)(C)=O)c2)n1.Nc1ccc(Oc2ccnc(Cl)n2)c2ccccc12.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)n(-c2cccc(P(C)(C)=O)c2)n1,,C1CCOC1,ClCCl,,,val
US20050107377A1,BrCCCOc1ccc(-c2csc3ccccc23)cc1.NCc1cccs1>>c1csc(CNCCCOc2ccc(-c3csc4ccccc34)cc2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100105667A1,COc1ccc(CN2CCN(Cc3ccc([N+](=O)[O-])cn3)CC2(C)C)cc1>>COc1ccc(CN2CCN(Cc3ccc(N)cn3)CC2(C)C)cc1,[Ni],C1CCOC1,CO,,,val
US05447718,CCCCC/C=C\C=C\C(=O)OCC>>CCCCC/C=C\C=C\C(=O)OC,,CO,,,,val
US20090156642A1,CN(Cc1cc(Br)c(S(=O)(=O)c2cccc(F)c2)s1)C(=O)OC(C)(C)C.OB(O)c1cccnc1F>>CN(Cc1cc(-c2cccnc2F)c(S(=O)(=O)c2cccc(F)c2)s1)C(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20020177708A1,Cc1ccc(Oc2cccc([N+](=O)[O-])c2)cc1>>Cc1ccc(Oc2cccc(N)c2)cc1,[Pd],CCO,,,,val
US20050020616A1,Nc1ccc2c(c1)C1CCC2CN(C(=O)C(F)(F)F)C1.[I-]>>O=C(N1CC2CCC(C1)c1cc(I)ccc12)C(F)(F)F,,O,O=S(=O)(O)O,O=N[O-].[Na+],,val
US20100305135A1,CC1(C)O[C@@H]2C(COC(c3ccccc3)(c3ccccc3)c3ccccc3)=C[C@@H]([C@H](O)CN)[C@@H]2O1.Clc1nccnc1Cl>>CC1(C)O[C@@H]2C(COC(c3ccccc3)(c3ccccc3)c3ccccc3)=C[C@@H]([C@H](O)CNc3nccnc3Cl)[C@@H]2O1,,CN(C)C=O,,CCN(CC)CC,,val
US05955607,CCC1(CC)CC(CCS(=O)(=O)NCC(=O)O)c2cc(C)ccc2O1.CCOCCOCCO>>CCOCCOCCOC(=O)CNS(=O)(=O)CCC1CC(CC)(CC)Oc2ccc(C)cc21,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05102890,CCC(=O)N1CCC(C(=O)O)CC1.O=C1c2ccccc2C(Cl)N1c1ccc2ccc(Cl)nc2n1>>CCC(=O)N1CCC(C(=O)OC2c3ccccc3C(=O)N2c2ccc3ccc(Cl)nc3n2)CC1,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US20140364396A1,Clc1nccc2ccccc12>>c1ccc2cnccc2c1,,CC(=O)O,,C,O=C[O-].[NH4+],val
US20090165221A1,CCN(CCBr)c1ccc(N=Nc2nc(C)c(C)s2)cc1.Cn1ccnc1>>CCN(CCn1cc[n+](C)c1)c1ccc(N=Nc2nc(C)c(C)s2)cc1.[Br-],,CC#N,,,,val
US04774248,Br[Mg]c1ccccc1.O=C(CCl)CCl>>OC(CCl)(CCl)c1ccccc1,,CCOCC,,CC(=O)O,O,val
US20120238540A1,COc1cc(-c2ccnc(Cl)n2)cc(C#N)c1OC1CCN(C(=O)OC(C)(C)C)CC1.Nc1ccc(N2CCOCC2)cc1>>COc1cc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc(C#N)c1OC1CCN(C(=O)OC(C)(C)C)CC1,,C1COCCO1,CCO,,,val
US20050107395A1,COc1ccccc1N1CCN(C[C@H](N)Cc2ccccn2)CC1.O=C(Cl)C1CCCCC1>>COc1ccccc1N1CCN(C[C@@H](Cc2ccccn2)NC(=O)C2CCCCC2)CC1,,ClCCl,,CCN(CC)CC,,val
US20100152158A1,COc1cc(C)c(S(=O)(=O)N2CCCCC2CCCS(=O)(=O)Cl)c(C)c1.c1cncc(C2(OCCN3CCCC3)CCC3(CCNCC3)CC2)c1>>COc1cc(C)c(S(=O)(=O)N2CCCCC2CCCS(=O)(=O)N2CCC3(CC2)CCC(OCCN2CCCC2)(c2cccnc2)CC3)c(C)c1,,ClCCl,,CCN(CC)CC,,val
US04395415,O=[N+]([O-])c1ccc(SCl)c(C(Cl)(Cl)Cl)c1.Oc1ccnc(S)n1>>O=[N+]([O-])c1ccc(SSc2nccc(O)n2)c(C(Cl)(Cl)Cl)c1,,O,,,,val
US05240938,C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1O[Si](C)(C)C(C)(C)C>>C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110062165A1,CCC[Mg]Cl.COC(=O)c1ccnc(Cl)c1>>CCCc1cc(C(=O)OC)ccn1,,C1CCOC1,COC(C)(C)C,CN1CCCC1=O,,val
US20140315917A1,Cc1nc(N)ccc1Oc1ccnc(Cl)c1.O=C(Cl)Cl.O=C1NCCN1C1CCOCC1>>Cc1nc(NC(=O)N2CCN(C3CCOCC3)C2=O)ccc1Oc1ccnc(Cl)c1,,ClCCl,,c1ccncc1,,val
US20140005388A1,CI.COc1nc(OC)nc(C2C(=O)Nc3c(F)cccc32)n1>>COc1nc(OC)nc(C2(C)C(=O)Nc3c(F)cccc32)n1,,CC#N,,[H-].[Na+],,val
US20070142446A1,CCNCC.COc1cccc2c(-c3nsc(COS(C)(=O)=O)n3)cn(CC3CCCCC3)c12.ClCCl>>CCN(CC)Cc1nc(-c2cn(CC3CCCCC3)c3c(OC)cccc23)ns1.Cl,,C1CCOC1,,,,val
US20130131039A1,CC1(C)OB(c2cnn(CCO)c2)OC1(C)C.CS(=O)(=O)Cl>>CC1(C)OB(c2cnn(CCOS(C)(=O)=O)c2)OC1(C)C,,ClCCl,,,,val
US20120264785A1,CC1=C(C#N)C(c2ccc3[nH]nc(C)c3c2)C(C#N)=C(C(F)(F)F)N1.CI>>CC1=C(C#N)C(c2ccc3[nH]nc(C)c3c2)C(C#N)=C(C(F)(F)F)N1C,,CN(C)C=O,CO,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110092526A1,COC(=O)c1cnc(N[C@@H]2CCOC2)nc1C1CCC1>>O=C(O)c1cnc(N[C@@H]2CCOC2)nc1C1CCC1,,CO,,[Na+].[OH-],,val
US20070208056A1,CCOC(=O)C(NC(=O)NNC(=O)c1ccccc1)C(C)C>>CCOC(=O)C(Nc1nnc(-c2ccccc2)o1)C(C)C,,ClCCCl,,O=P(Cl)(Cl)Cl,,val
US20110190342A1,Cc1ccc(Oc2ccc(C[C@H](N)C(=O)O)cc2)nc1.O=C(O)c1cc2cc(Cl)ccc2nc1Cl>>Cc1ccc(Oc2ccc(C[C@H](Nc3nc4ccc(Cl)cc4cc3C(=O)O)C(=O)O)cc2)nc1,,CS(C)=O,,,,val
US05374641,COC(=O)c1ccc(CC(=O)c2cccnc2)cc1.O=C[O-].[NH4+]>>COC(=O)c1ccc(CC(NC=O)c2cccnc2)cc1,,O,,,,val
US20060252811A1,CCOC(=O)C(Cc1ccccc1)Cc1nccn1Cc1cc(Cl)cc(Cl)c1>>O=C(O)C(Cc1ccccc1)Cc1nccn1Cc1cc(Cl)cc(Cl)c1,,C1CCOC1,,Cl,,val
US20060100246A1,CON(C)C(=O)C1CCCN(C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N1CCCC(C=O)C1,,C1CCOC1,CCOCC,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060025430A1,COCC(=O)Cl.Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1>>COCC(=O)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20070037794A1,COc1cccc(NC(=O)C(C)(C)C)c1C(O)c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>COc1cccc(NC(=O)C(C)(C)C)c1C(=O)c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20100256097A1,CCOC(=N)c1ccc(Br)cc1>>CCOC(=N)c1ccc(Br)cc1,,CCO,,Cl,,val
US03961055,COc1ccc2c(c1)N(CCCCl)c1cccc(SC)c1S2.OCCC1CCNCC1>>COc1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1cccc(SC)c1S2,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20020193382A1,COC(=O)C1(CN2CCN(S(=O)(=O)C3=Cc4ccc(Cl)cc4OC3)CC2=O)CCN(C(=O)OC(C)(C)C)CC1.Cl>>COC(=O)C1(CN2CCN(S(=O)(=O)C3=Cc4ccc(Cl)cc4OC3)CC2=O)CCNCC1.Cl,,CCOC(C)=O,CO,,,val
US20080009482A1,CCN1CC[C@@H](N)C1.COc1cc(C(=O)O)ccc1N>>CCN1CC[C@@H](NC(=O)c2ccc(N)c(OC)c2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130029961A1,C=C(OS(=O)(=O)C(F)(F)F)C(=O)OC.CC1(C)OB(c2cnc(C(=O)N(COCC[Si](C)(C)C)c3ccc(F)cc3)nc2)OC1(C)C>>C=C(C(=O)OC)c1cnc(C(=O)N(COCC[Si](C)(C)C)c2ccc(F)cc2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20090105302A1,C=CCCCCN(C)C(=O)C1CC(OCOCC)CC1C(=O)NC1(C(=O)OCC)CC1C=C>>CCOCOC1CC2C(=O)NC3(C(=O)OCC)CC3C=CCCCCN(C)C(=O)C2C1,,CC(Cl)Cl,,,,val
US06107337,COC(=O)CCN(C1(C(=O)NO)CCCC1)S(=O)(=O)c1ccc(-c2ccc(F)cc2)cc1>>O=C(O)CCN(C1(C(=O)NO)CCCC1)S(=O)(=O)c1ccc(-c2ccc(F)cc2)cc1,,CO,,[Na+].[OH-],,val
US20110002855A1,Cn1c2c(c3cccnc31)CCNC2.O=C(CCl)N1CCN(C2CCC2)CC1>>Cn1c2c(c3cccnc31)CCN(CC(=O)N1CCN(C3CCC3)CC1)C2,,CC#N,ClCCl,[I-].[K+],O=C([O-])O.[Na+],val
US20130172323A1,CCC(C(=O)c1ccc(NCc2ccccc2)c(O)c1)C(C)C(=O)O.NN>>CCC1C(c2ccc(NCc3ccccc3)c(O)c2)=NNC(=O)C1C,,CC(=O)O,,O,,val
US20030013875A1,CCCCCCN1CC2C(C1=O)C2(C)c1cccc(-c2ccccn2)c1>>CCCCCCN1CC2C(C1)C2(C)c1cccc(-c2ccccn2)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140243322A1,CC(C)(C)OC(=O)NCC(=O)O.COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCN)c1nnc(C)n1-2>>COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCNC(=O)CNC(=O)OC(C)(C)C)c1nnc(C)n1-2,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US03981905,CCOC(=O)C(C)(C(=O)[O-])c1ccc(Oc2ccc(F)cc2)cc1>>CC(C(=O)O)c1ccc(Oc2ccc(F)cc2)cc1,,CCO,,[Na+].[OH-],,val
US20120165298A1,CC1CC(N2CCn3c(nnc3NS(=O)(=O)c3ccc(N[C@H](CCN4CCOCC4)CS(=O)(=O)c4ccccc4)c(S(=O)(=O)C(F)(F)F)c3)C2)CCN1C(=O)OC(C)(C)C>>CC1CC(N2CCn3c(nnc3NS(=O)(=O)c3ccc(N[C@H](CCN4CCOCC4)CSc4ccccc4)c(S(=O)(=O)C(F)(F)F)c3)C2)CCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100311747A1,CCC1(NCC(=O)N2CCC[C@H]2C#N)CC2CN(C(=O)N(C)C)CC2C1.O=C(O)C(O)C(O)C(=O)O>>CCC1(NCC(=O)N2CCC[C@H]2C#N)CC2CN(C(=O)N(C)C)CC2C1.O=C(O)C(O)C(O)C(=O)O,,CC(C)=O,CCOC(C)=O,,,val
US20110112110A1,COc1ccc(B(O)O)c(Cl)c1Cl.CSc1ncc(-c2ccc(Br)cn2)s1>>COc1ccc(-c2ccc(-c3cnc(SC)s3)nc2)c(Cl)c1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US05037987,CC1=C(C(=O)OCc2ccccc2)C(c2ccccc2C(F)(F)F)c2c(ccnc2OC(C)C)N1>>CC1=C(C(=O)O)C(c2ccccc2C(F)(F)F)c2c(ccnc2OC(C)C)N1,[Pd],CCO,,,,val
US20100280083A1,CC(C)C=O.COc1cc(-c2noc(C)n2)c(I)cc1OCc1ccccc1>>COc1cc(-c2noc(C)n2)c(C(O)C(C)C)cc1OCc1ccccc1,,C1CCOC1,O,CC(C)[Mg]Cl,Cl,val
US20150080549A1,CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)[C@H](CSSC(C)(C)C)NC(=O)OCc1ccc(N=[N+]=[N-])cc1)C(=O)O.N#CCBr>>CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)[C@H](CSSC(C)(C)C)NC(=O)OCc1ccc(N=[N+]=[N-])cc1)C(=O)OCC#N,,CC#N,,CCN(C(C)C)C(C)C,,val
US20120040954A1,CC(=O)NC1CCNCC1.O=Cc1ccc(F)cc1>>CC(=O)NC1CCN(c2ccc(C=O)cc2)CC1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US05712300,CC(C)CC1(CC(=O)OC(C)(C)C)CCN(CCc2ccccc2)C1=O.CI>>CC(C)CC1(C(C)C(=O)OC(C)(C)C)CCN(CCc2ccccc2)C1=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20110118245A1,COCCOc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC.COc1cc(NC(=O)Oc2ccccc2)ccc1C(F)(F)F>>COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4ccc(C(F)(F)F)c(OC)c4)c3)c2cc1OC,CN(C)c1ccncc1,,,CCN(C(C)C)C(C)C,,val
US04419121,COc1ccccc1S(N)(=O)=O>>NS(=O)(=O)c1ccccc1O,,ClCCl,,BrB(Br)Br,CO,val
US05436247,CCOC(=O)CC(=O)CCl.COc1ccc(C(=O)c2cc3c(cc2N)OCCO3)cc1OC>>CCOC(=O)c1c(CCl)nc2cc3c(cc2c1-c1ccc(OC)c(OC)c1)OCCO3,,CC(=O)O,,O=S(=O)(O)O,,val
US20130130997A1,BrBr.FC(F)(F)Oc1ccccc1>>FC(F)(F)Oc1ccc(Br)cc1,[Fe],,,ClCCl,,val
US20110206653A1,COc1c(CO)cccc1OCc1c(C)cccc1C.CS(=O)(=O)Cl>>COc1c(COS(C)(=O)=O)cccc1OCc1c(C)cccc1C,,ClCCl,,CCN(CC)CC,,val
US20120046271A1,COc1cccc(CN2CCC(=O)CC2)c1.Fc1ccc([Mg]Br)cc1Cl>>COc1cccc(CN2CCC(O)(c3ccc(F)c(Cl)c3)CC2)c1,,C1CCOC1,,,,val
US20150246902A1,COc1cc(Br)cc(Nc2cc(F)cc(F)c2)c1N.N#CBr>>COc1cc(Br)cc2c1nc(N)n2-c1cc(F)cc(F)c1,,CO,,,,val
US06030967,O=C(OO)c1cccc(Cl)c1.O=C1NCc2c1cc1ccc3c(c1c2-c1ccncc1)OCO3>>O=C1c2cc3ccc4c(c3c(-c3ccncc3)c2C[NH+]1[O-])OCO4,,O,,ClCCl,,val
US05556864,COc1cc(CCCCc2ccccc2OCC2CO2)cc(OC)c1.OC1CCNCC1>>COc1cc(CCCCc2ccccc2OCC(O)CN2CCC(O)CC2)cc(OC)c1,,C1CCOC1,CO,Cl,CC(C)(C)[O-].[K+],val
US20070060607A1,CCOC(=O)c1cnc(N)c2c(COc3cccc(Nc4ccccc4)c3)csc12.NCCO>>Nc1ncc(C(=O)NCCO)c2scc(COc3cccc(Nc4ccccc4)c3)c12,,CS(C)=O,,,,val
US20070259854A1,CN=C=S.Cc1csc(C2(C(=O)NN)CCCC2)c1Cl>>CNC(=S)NNC(=O)C1(c2scc(C)c2Cl)CCCC1,,CCO,,,,val
US20090209571A1,COc1cccc(B(O)O)c1.O=Cc1cccnc1Br>>COc1cccc(-c2ncccc2C=O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20130317002A1,CC(C)N.Clc1nc2nc(-c3ccccn3)nn2c(Cl)c1-c1ccccc1>>CC(C)Nc1c(-c2ccccc2)c(Cl)nc2nc(-c3ccccn3)nn12,,CN(C)C=O,,,,val
US05770597,C1CCOC1.C[N+](=O)[O-].O=C(O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O>>COc1c(F)c(F)cc2c(=O)c(C(=O)C[N+](=O)[O-])cn(C3CC3)c12,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20070105913A1,CCCCc1ccc(C#Cc2ccc(CN(C(=O)COCc3ccccc3)c3ccc4c(c3)C(=O)OC(C)(C)O4)cc2)cc1>>CCCCc1ccc(C#Cc2ccc(CN(C(=O)COCc3ccccc3)c3ccc(O)c(C(=O)O)c3)cc2)cc1,,CCO,,[Na+].[OH-],,val
US05547962,Cc1c(N2C[C@@H](NC(=O)C(F)(F)F)[C@@H](C)C2)c(F)c(N)c2c(=O)c(C(=O)O)cn(C3CC3)c12>>Cc1c(N2C[C@@H](N)[C@@H](C)C2)c(F)c(N)c2c(=O)c(C(=O)O)cn(C3CC3)c12,,O,,Cl,[K+].[OH-],val
US20120040951A1,CC(=O)N1C=CN=C(Cl)C1.Nc1ccc(C(F)(F)F)cc1>>CC(=O)c1cnc(Nc2ccc(C(F)(F)F)cc2)cn1,,C1COCCO1,,CCO,Cl,val
US20100298347A1,CCOC(=O)c1cc(-c2ccsc2)c2ccc(OCc3ccccc3)cc2c1>>CCOC(=O)c1cc(-c2ccsc2)c2ccc(O)cc2c1,,ClCCl,,BrB(Br)Br,,val
US20160207926A1,CCn1c(CC2CN(C(=O)OC(C)(C)C)C2)nc2c(N[C@H]3CCN(C(=O)C4CC4)C3)ncnc21.O=C(O)C(F)(F)F>>CCn1c(CC2CNC2)nc2c(N[C@H]3CCN(C(=O)C4CC4)C3)ncnc21.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04670421,CI.C[Si](C)(C)CCCCCCCCCCCCCCNc1ccc(C(=O)O)cc1>>COC(=O)c1ccc(NCCCCCCCCCCCCCC[Si](C)(C)C)cc1,,CN(C)P(=O)(N(C)C)N(C)C,,[H-].[Na+],,val
US20070161673A1,Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(N)n[nH]c2n1.O=C(Cl)c1ccc(F)cc1>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(NC(=O)c3ccc(F)cc3)n[nH]c2n1,,c1ccncc1,,,,val
US04698352,COC(=O)CC(=O)C=Cc1ccc(Cl)cc1.Nc1ccc(F)cc1.c1ccccc1>>COC(=O)C(=CNc1ccc(F)cc1)C(=O)C=Cc1ccc(Cl)cc1,,c1ccccc1,,CCOCC,,val
US20150291573A1,CSc1ccc(C2CC(C)(S(=O)(=O)c3cccc(OS(=O)(=O)C(F)(F)F)c3)CCO2)c(F)c1.OB(O)C1CC1>>CSc1ccc(C2CC(C)(S(=O)(=O)c3cccc(C4CC4)c3)CCO2)c(F)c1,,Cc1ccccc1,O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],val
US20070208055A1,CC(C)(C)OC(=O)OC(C)(C)C.O=C1CC[C@@H](C(=O)OCc2ccccc2)N1>>CC(C)(C)OC(=O)N1C(=O)CC[C@H]1C(=O)OCc1ccccc1,,ClCCl,,CN(C)c1ccccn1,,val
US20130225524A1,CC(C)=Cc1cc(N)cc(C(=O)O)c1>>CC(C)Cc1cc(N)cc(C(=O)O)c1,[Pd],CO,,,,val
US03962249,Cc1ccccc1CCCN1CCNCC1.O=C(Cl)c1ccco1>>Cc1ccccc1CCCN1CCN(C(=O)c2ccco2)CC1.Cl,,c1ccccc1,,,,val
US05382379,Fc1cc(C2=CCC3(CC2)OCCO3)cc(F)c1F>>Fc1cc(C2CCC3(CC2)OCCO3)cc(F)c1F,[Pd],CCO,,[H][H],,val
US20050004154A1,CN(C)CCCl.Cl.O=C1NCN(c2ccccc2)C12CCN(CCc1ccccc1-c1cccs1)CC2>>CN(C)CCN1CN(c2ccccc2)C2(CCN(CCc3ccccc3-c3cccs3)CC2)C1=O.Cl,,CN(C)C=O,,[H-].[Na+],,val
US20100113465A1,Cc1nnc(N)o1.O=C(Cl)Oc1ccccc1>>Cc1nnc(NC(=O)Oc2ccccc2)o1,,C1CCOC1,CCOCC,,,val
US20110201793A1,CC(C)(C)C(=O)OC[C@H]1O[C@H](Br)[C@H](OC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@@H]1OC(=O)C(C)(C)C.CC(C)c1c(Cc2ccccc2)c(=O)[nH]n1C=O>>CC(C)c1c(Cc2ccccc2)c(O[C@@H]2O[C@H](COC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@H](OC(=O)C(C)(C)C)[C@H]2OC(=O)C(C)(C)C)nn1C=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04150131,CCOC(=O)Nc1cc(N(C)C)nc(NC(=O)OCC)[n+]1[O-]>>CCOC(=O)Nc1cc(N(C)C)nc2nc(=O)on12,,CN(C)C=O,,,,val
US20100210452A1,COC(=O)/C=C/C(=O)C1CCCCC1.O=CCCc1ccccc1Cl>>COC(=O)[C@H]1C=C(C2CCCCC2)OC(=O)[C@H]1Cc1ccccc1,,ClC(Cl)Cl,,,,val
US20100016311A1,CCOP(=O)(Cc1cccc(C(=O)OC)c1)OCC.COc1cccc(C=O)c1>>COC(=O)c1cccc(/C=C/c2cccc(OC)c2)c1,,C1CCOC1,,[H-].[Na+],,val
US20130172292A1,CCI.COC(=O)c1n[nH]cc1[N+](=O)[O-]>>CCn1ncc([N+](=O)[O-])c1C(=O)OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060257987A1,CCOC(=O)CSc1ccc(OCCC(C)Oc2ccc(CC)cc2Oc2ccccc2)cc1C>>CCc1ccc(O[C@H](C)CCOc2ccc(SCC(=O)O)c(C)c2)c(Oc2ccccc2)c1,,CCO,O,Cl,[Na+].[OH-],val
US20100075951A1,CCOC(=O)c1sc(N)c(C#N)c1-c1ccc(Cl)cc1Cl.ICI>>CCOC(=O)c1sc(I)c(C#N)c1-c1ccc(Cl)cc1Cl,,CC#N,,CC(C)CCON=O,,val
US20130023522A1,Cc1ccccc1N1CCN(c2ccc(C(=O)O)cc2NC(=O)c2ccco2)CC1.NCCCc1ccccc1>>Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3ccccc3)cc2NC(=O)c2ccco2)CC1,,ClCCl,,CCN(CC)CC,,val
US20050272778A1,CCOC(=O)C1(Cc2ccc(C3=CC(=O)N(C(C)(C)C)S3(=O)=O)cc2)CCC(=O)N1>>CCOC(=O)C1(Cc2ccc(C3CC(=O)N(C(C)(C)C)S3(=O)=O)cc2)CCC(=O)N1,[Pd],CCO,,[H][H],,val
US20020028797A1,CC#CCC(CC#CC)(C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1>>CC#CCC(CC#CC)(C(=O)O)S(=O)(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080009530A1,CCCCOC(=O)Cl.CCCCOc1cc(CCS(N)(=O)=O)n(Cc2ccc(Cl)cc2Cl)n1>>CCCCOC(=O)NS(=O)(=O)CCc1cc(OCCCC)nn1Cc1ccc(Cl)cc1Cl,CN(C)c1ccncc1,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20090291937A1,BrCCBr.N#CCc1cc(Br)cc(Br)c1>>N#CC1(c2cc(Br)cc(Br)c2)CC1,,CS(C)=O,,O,[H-].[Na+],val
US20110009354A1,CBr.CSC[C@H]1O[C@@H](n2c(C)nc3c(N)ncnc32)[C@H](O)[C@@H]1O>>Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](C[S+](C)C)[C@@H](O)[C@H]1O.[Br-],,CCOCC,,CC(=O)O,,val
US20090253709A1,C1CCNCC1.O=C(CCCl)Nc1ccc2c(c1)C(=O)c1cc(NC(=O)CCCl)ccc1C2=O.c1ccncc1>>O=C(CCN1CCCCC1)Nc1ccc2c(c1)C(=O)c1cc(NC(=O)CCN3CCCCC3)ccc1C2=O,,CN(C)C=O,,,,val
US20150119380A1,CSc1ccnc(C)n1.O=C(CBr)c1cc2ccc(F)cc2oc1=O>>CSc1cc[n+](CC(=O)c2cc3ccc(F)cc3oc2=O)c(C)n1.[Br-],,CC#N,,,,val
US20050148549A1,CCCCCCCCCCC(O)C(=O)N[C@H](/C=C/C(=O)OCc1ccccc1)CCCC>>CCCCCCCCCCC(O)C(=O)N[C@@H](CCCC)CCC(=O)O,[Pd],CCO,,N#N,,val
US20120101083A1,CC(C)(C)OC(=O)NC(=O)CN.CCOc1ncc(-c2nc(-c3ccc4c(c3)CCNCC4)no2)cc1C#N>>CCOc1ncc(-c2nc(-c3ccc4c(c3)CCN(C(=O)CNC(=O)OC(C)(C)C)CC4)no2)cc1C#N,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05385925,CCCC(=O)Cl.COC(=O)c1ccc(N)c(N)c1>>CCCc1nc2ccc(C(=O)OC)cc2[nH]1,,O=P(Cl)(Cl)Cl,,Cl,Cl,val
US20140148474A1,N#C[C@@H]1CC[C@@H](C(=O)O)CC1.O=S(Cl)Cl>>N#C[C@@H]1CC[C@@H](C(=O)Cl)CC1,,ClCCl,,,,val
US04853151,CCC[C@@H]1CC[C@@H](C2CCC3(CC2)C(=O)C2(CCC([C@H]4CC[C@H](CCC)CC4)CC2)C3=O)CC1>>CCCCCCCC(=O)CCCCCC,,ClC(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20150087646A1,NC(=O)c1ccc(Cl)cc1F.O=C(Cl)C(=O)Cl>>O=C=NC(=O)c1ccc(Cl)cc1F,,ClCCCl,,,,val
US20100113539A1,N#CCC(O)c1cccc(N)c1.O=Cc1ccccc1>>N#CCC(O)c1cccc(NCc2ccccc2)c1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110230462A1,CC(C)(C)OC(=O)N1CCC(C#N)C1.CI>>CC1(C#N)CCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20050026916A1,ClCc1ccc(-c2ccccc2)cc1.S=C1N[C@@H](c2ccccc2)[C@@H](c2ccccc2)N1>>Cl.c1ccc(-c2ccc(CSC3=N[C@@H](c4ccccc4)[C@@H](c4ccccc4)N3)cc2)cc1,,CCO,,,,val
US20110152318A1,Oc1cccc2c1CC=C2C(F)(F)F>>Oc1cccc2c1CCC2C(F)(F)F,[Pd],CCOC(C)=O,CO,[H][H],,val
US20040097589A1,O=[N+]([O-])c1ccc(F)cc1.Oc1c(Br)cc(Br)cc1Br>>O=[N+]([O-])c1ccc(Oc2c(Br)cc(Br)cc2Br)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160222012A1,C=CCC(c1cc2ccc(F)cc2nc1Cl)N(CC=C)C(=O)OCc1ccccc1>>O=C(OCc1ccccc1)N1CC=CCC1c1cc2ccc(F)cc2nc1Cl,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US04900652,CCCCCCS(=O)(=O)Nc1ccc2oc(C)[n+](CC)c2c1.Cc1ccc(S(=O)(=O)[O-])cc1.N=CN(c1ccccc1)c1ccccc1>>CCCCCCS(=O)(=O)Nc1ccc2oc(C=CNc3ccccc3)[n+](CC)c2c1.Cc1ccc(S(=O)(=O)[O-])cc1,,CC(C)=O,,,,val
US20140288123A1,COC(=O)c1ccc(C(C)O)nn1.Oc1ccccc1>>COC(=O)c1ccc(C(C)Oc2ccccc2)nn1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100292242A1,CC(C)(C)OC(=O)N1Cc2cc(-c3ccc(Cl)nn3)ccc2C(c2ccc(Cl)c(Cl)c2)C1>>Clc1ccc(C2CNCc3cc(-c4cccnn4)ccc32)cc1Cl,[Pd],CCO,,NN,O,val
US20110021522A1,COc1cccc2cc(C(=O)O)c(=O)oc12.Nc1cccc(-c2ccc3c(c2)CCO3)c1>>COc1cccc2cc(C(=O)Nc3cccc(-c4ccc5c(c4)CCO5)c3)c(=O)oc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05241076,CCO.c1ccc(CN2CCC3CNCC32)cc1>>CC1C2NCCC2CN1C,[Pd],,,,,val
US20130116216A1,C=CC(=O)Nc1ccc(S(=O)(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c(OC)c1>>C=CC(=O)Nc1ccc(S(=O)(=O)N2CCNCC2)c(OC)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110230486A1,CCc1ccc(Oc2cc(C)c(C(=O)CBr)c(C)c2)cc1.NC(N)=S>>CCc1ccc(Oc2cc(C)c(-c3csc(N)n3)c(C)c2)cc1,,CCO,,,,val
US05741796,CC(C)(C)OC(=O)[C@H](CNC(=O)c1ccc(COCCNC(=O)OCc2ccccc2)cc1)NS(=O)(=O)c1ccccc1>>NCCOCc1ccc(C(=O)NC[C@H](NS(=O)(=O)c2ccccc2)C(=O)O)cc1,,CC(=O)O,,Br,,val
US20090264445A1,CCOC(=O)C=C(CN[C@@H](CC(C)C)C(=O)OC)Oc1ccc(OC)cc1>>COC(=O)[C@H](CC(C)C)N1CC(Oc2ccc(OC)cc2)=CC1=O,,C1CCOC1,,,,val
US20060160875A1,C1CSCN1.O=C(O)CC(O)CCc1ccc(-c2ccccc2)cc1>>O=C(CC(O)CCc1ccc(-c2ccccc2)cc1)N1CCSC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05185442,COC(=O)c1ccc(C(=O)OC)c([N+](=O)[O-])c1>>COC(=O)c1ccc(C(=O)OC)c(N)c1,[Pd],C1CCOC1,CO,,,val
US20120171245A1,CC(C)(C)OC(=O)N1CCC[C@H](N)C1.Fc1cnc(Cl)nc1Cl>>CC(C)(C)OC(=O)N1CCC[C@H](Nc2nc(Cl)ncc2F)C1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20150291624A1,CC(C)(n1cc(C#N)cc1N)C(F)(F)F.COC(CC(OC)OC)OC>>CC(C)(n1cc(C#N)c2cccnc21)C(F)(F)F,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04757081,CC(C(=O)CC(=O)c1ccccc1)C(=O)c1ccccc1.Nc1c(F)cccc1F>>Cc1c(-c2ccccc2)n(-c2c(F)cccc2F)c(-c2ccccc2)cc1=O,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20030087897A1,COc1cc(OC)c(CN(OCc2ccccc2)C(=O)CCC(Cc2ccc(C(=O)O)cc2)(C(=O)O)C(=O)O)c(OC)c1>>COc1cc(OC)c(CN(OCc2ccccc2)C(=O)CCC(Cc2ccc(C(=O)O)cc2)C(=O)O)c(OC)c1,,CS(C)=O,,,,val
US20040171634A1,O=C1C=C(Cl)CCC1.Oc1cccc(N=C(c2ccccc2)c2ccccc2)c1>>O=C1C=C(Oc2cccc(N=C(c3ccccc3)c3ccccc3)c2)CCC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20070111984A1,CN(C)C=O.O=C(O)c1cc(F)ccc1Br>>NC(=O)c1cc(F)ccc1Br,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US04062798,CCCCCCc1ccc(-c2ccc(-c3ncc(C(=O)OCC)cn3)cc2)cc1>>CCCCCCc1ccc(-c2ccc(-c3ncc(C(=O)O)cn3)cc2)cc1,,CCO,,[Na+].[OH-],,val
US20080090916A1,COc1ccc(OC)c([C@@H](O)[C@H](C)NC(=O)CC[C@H](NC(=O)OCc2ccccc2)C(=O)OCc2ccccc2)c1>>COc1ccc(OC)c([C@@H](O)[C@H](C)NC(=O)CC[C@H](N)C(=O)O)c1,[Pd],CO,,,,val
US20040023974A1,CCC(CC)COC(=O)c1ccc(CN2CC(=O)N(Cc3ccc(OC)cc3OC)S2(=O)=O)cc1>>CCC(CC)COC(=O)c1ccc(CN2CC(=O)NS2(=O)=O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04548932,Cc1ccc(S(=O)(=O)Cl)cc1.O=C(OCc1ccccc1)N1CCC(CCCCCO)CC1>>Cc1ccc(S(=O)(=O)OCCCCCC2CCN(C(=O)OCc3ccccc3)CC2)cc1,,CCOC(C)=O,,c1ccncc1,,val
US20150274701A1,C#CCN(CC#C)CCCO.CCOC(=O)CCCCN=[N+]=[N-]>>C#CCN(CCCO)Cc1cn(CCCCC(=O)OCC)nn1,,CC(C)(C)O,O,O=C(CO)O[CH][C@@H](O)CO,C[O-].[Na+],val
US20060116515A1,CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)O.NCc1ccc2c(c1)OCO2>>CC(C)(C)OC(=O)N1CCCC1C(=O)NCc1ccc2c(c1)OCO2,,CN(C)C=O,ClCCl,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040147569A1,CC(Br)C(=O)OC(C)(C)C.OCc1cccnc1>>CC(C)(C)OC(=O)COCc1cccnc1,,C1CCOC1,,O,[H-].[Na+],val
US08653089B2,C[C@H](N)c1nc2ccc(F)cc2n1-c1ccccc1.N#Cc1cnc(N)nc1Cl>>C[C@H](Nc1nc(N)ncc1C#N)c1nc2ccc(F)cc2n1-c1ccccc1,,CC(C)O,CO,CCN(C(C)C)C(C)C,,val
US20080090802A1,COc1cc(-c2nc3ccc(N4CCCNCC4)cc3c(=O)n2CC(=O)NC(C)C)ccc1F.OCCBr>>COc1cc(-c2nc3ccc(N4CCCN(CCO)CC4)cc3c(=O)n2CC(=O)NC(C)C)ccc1F,,CN(C)C=O,,[I-].[K+],,val
US06117875,C=Cc1cccc(N)c1.O=[N+]([O-])c1cccnc1Cl>>C=Cc1cccc(Nc2ncccc2[N+](=O)[O-])c1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US05284847,CCOC(=O)C(=O)Nc1ccc(-c2ccccc2)s1.O=[N+]([O-])O>>CCOC(=O)C(=O)Nc1sc(-c2ccccc2)cc1[N+](=O)[O-],,CC(=O)O,CC(=O)OC(C)=O,,,val
US20090275590A1,CNC.Cn1c2c(c3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc31)CNCC2.O=C(Cl)CCl>>CN(C)CC(=O)N1CCc2c(c3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc3n2C)C1,,CN(C)C=O,ClCCl,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20120238748A1,Brc1ccc2ccc3cccnc3c2n1.COS(=O)(=O)OC>>C[n+]1cccc2ccc3ccc(Br)nc3c21.O=S(=O)([O-])O,,CCOCC,,,,val
US04129653,CCOC(=O)C(=O)CBr.CCOC(=O)Cc1ncnc2ccccc12>>CCOC(=O)c1cn2cnc3ccccc3c2c1C(=O)OCC,,CCO,,O=C([O-])O.[Na+],,val
US20110034455A1,O=C(NC1C2CC3CC(C2)CC1C3)N1CCCC2(Cc3ccccc3C2=O)C1>>O=C(NC1C2CC3CC(C2)CC1C3)N1CCCC2(Cc3ccccc3C2O)C1,,CO,,[BH4-].[Na+],,val
US20020119983A1,FC(F)(F)c1ccccc1CN1CCNCC1.O=CCCc1cc(C=Cc2ccccc2)no1>>FC(F)(F)c1ccccc1CN1CCN(CCCc2cc(C=Cc3ccccc3)no2)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080306124A1,C#Cc1ccc(-c2ccccc2)c(C(F)(F)F)c1.ON=Cc1ccc(Br)cc1>>FC(F)(F)c1cc(-c2cc(-c3ccc(Br)cc3)no2)ccc1-c1ccccc1,,ClCCl,,[Na+].[O-]Cl,,val
US20070275987A1,NC(=O)c1cccnc1NC(=O)COCc1ccccc1>>O=c1[nH]c(COCc2ccccc2)nc2ncccc12,,CCO,O,O=C([O-])[O-].[Na+].[Na+],,val
US20060264460A1,C[Mg]Br.O=Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CC(O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,,C1CCOC1,,,,val
US04492597,Cc1c(Cl)cccc1NN=C1N=C(c2ccccc2)OC1=O.[NH4+]>>Cc1c(Cl)cccc1-n1nc(C(N)=O)nc1-c1ccccc1,,CC(C)=O,,Cl,,val
US20130102643A1,CCC(C(O)c1ccc(NC(C)=O)cc1)N(C)C.O=C(n1ccnc1)n1ccnc1>>CCC(C(c1ccc(NC(C)=O)cc1)n1ccnc1)N(C)C,,CC#N,,,,val
US04576938,CC(=O)Nn1nnnc1SCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1.CO/N=C(\C(=O)On1nnc2ccccc21)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nnnn3NC(C)=O)CS[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,ClCCl,,CCN(CC)CC,,val
US20160031877A1,Nc1ccc(Br)c(Br)c1.O=c1ncc2cc(F)ncc2[nH]1>>Fc1cc2c(Nc3ccc(Br)c(Br)c3)ncnc2cn1,CN(C)C=O,CC(=O)N(C)C,,O=S(Cl)Cl,,val
US07307086B2,NCCc1ccc(C(F)(F)F)cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(NCCc1ccc(C(F)(F)F)cc1)C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160046560A1,COC(=O)c1cc(N)ccc1O.ClCCOCCCl>>COC(=O)c1cc(N2CCOCC2)ccc1O,,Cc1ccccc1,,CCN(C(C)C)C(C)C,[I-].[Na+],val
US05347013,CCCN(CCC)[C@@H]1Cc2c(Br)ccc3c2[C@@H](C1)CN3C(=O)c1ccccc1>>CCCN(CCC)[C@@H]1Cc2c(Br)ccc3c2[C@H](CN3)C1,,C1CCOC1,CCCCCC,Cl,[Li]CCCC,val
US05641788,CC(=O)CC(C)=O.COc1ccc(C(=O)c2cc(OC)c(OC)cc2N)cc1OC>>COc1ccc(-c2c(C(C)=O)c(C)nc3cc(OC)c(OC)cc23)cc1OC,,CC(=O)O,,O=S(=O)(O)O,,val
US03974145,CC=O.NNc1ccc2c(c1)OCCO2>>CC=NNc1ccc2c(c1)OCCO2,,CCOCC,,,,val
US20120329785A1,COc1cc(N)ccc1OCC(=O)O.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1>>COc1ccc2nc(Nc3ccc(OCC(=O)O)c(OC)c3)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US04851535,C1CNCCN1.CCOC(=O)CC(=O)c1cc(F)c(OS(=O)(=O)c2c(C)cc(C)cc2C)nc1Nc1ccc(F)cc1F>>CCOC(=O)CC(=O)c1cc(F)c(N2CCNCC2)nc1Nc1ccc(F)cc1F,,CCCCCC,ClCCl,CCOC(C)=O,O,val
US20100168418A1,CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCN(CCn2c(=O)ccc3c(Br)cccc32)CC1>>O=c1ccc2c(Br)cccc2n1CCN1CCC(NCc2ccc3c(c2)OCCO3)CC1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20090074675A1,COc1ccc(NN)cc1.Cc1cc(Br)c(C=O)c(Br)c1>>COc1ccc(NN=Cc2c(Br)cc(C)cc2Br)cc1,,CO,,Cl,O=C([O-])O.[Na+],val
US20080096935A1,BrCCCCBr.COC(=O)CCc1ccc(O)cc1>>COC(=O)CCc1ccc(OCCCCBr)cc1,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04336056,CC(C)(C)c1cc(N=C=O)no1.CNC>>CN(C)C(=O)Nc1cc(C(C)(C)C)on1,,c1ccccc1,,,,val
US20040157836A1,CCN(CC)CCN.Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCN(CC)CCNC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2,,c1ccncc1,,,,val
US20110143149A1,CCOC(C)=O.COC(=O)C(F)(F)F.CO[Si](CCCN(C)C)(OC)OC>>CO[Si](CCC[N+](C)(C)C)(OC)OC.O=C([O-])C(F)(F)F,,CCOC(C)=O,,,,val
US04413127,CC(=O)Cc1ccncc1.CCOC(OCC)OCC>>CCOC=C(C(C)=O)c1ccncc1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20020137689A1,CNCC(O)C(O)C(O)C(O)CO.O=C1C(CCC(O)c2ccc(F)cc2)C(c2ccc(OCCCCCCCCI)cc2)N1c1ccc(F)cc1>>CN(CCCCCCCCOc1ccc(C2C(CCC(O)c3ccc(F)cc3)C(=O)N2c2ccc(F)cc2)cc1)CC(O)C(O)C(O)C(O)CO,,CN(C)C=O,,,,val
US20040024208A1,CCOC(=O)c1sc(NOC(=O)OC(C)(C)C)nc1C(F)(F)F>>CC(C)(C)OC(=O)ONc1nc(C(F)(F)F)c(C(=O)O)s1,,CO,,Cl,[Na+].[OH-],val
US20060094707A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C/C(=C\c1ccc(N)c(C)c1[N+](=O)[O-])C(=O)OCC.CN(C)c1ccccn1>>CCOC(=O)CC1Cc2ccc(N)c(C)c2N(CC(C)(C)C)C1=O,[Fe],C1CCOC1,,[Cl-].[NH4+],,val
US20100048610A1,CON(C)C(=O)c1cccnc1OC(F)F.C[Mg]Br>>CC(=O)c1ccc(OC(F)F)nc1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20140323480A1,BrCc1cccc2ccccc12.Clc1cc(Cl)c2[nH]cnc2n1>>Clc1cc(Cl)c2ncn(Cc3cccc4ccccc34)c2n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04760068,C=CC(O)(c1ccccc1)c1cccnc1.COC(=O)c1cccc(O)c1>>COC(=O)c1cccc(OCC=C(c2ccccc2)c2cccnc2)c1,,CN(C)C=O,ClCCl,[H-].[Na+],,val
US05162534,CCOC(CN)OCC.CI.S=C=S>>CCOC(CNC(=S)SC)OCC,,C1CCOC1,,CCN(CC)CC,,val
US20130131040A1,CC(C)C[C@@H](Nc1cnc(C#N)c(Nc2cccc3c2ccn3C)n1)C(N)=O.OO>>CC(C)C[C@@H](Nc1cnc(C(N)=O)c(Nc2cccc3c2ccn3C)n1)C(N)=O,,CCO,CS(C)=O,CC(=O)O,[Na+].[OH-],val
US20160039797A1,C#Cc1cc(Nc2nccc(Oc3ccc(N)c4ccccc34)n2)cc(C(=O)NCCOCCOCCOC)c1.O=C(Cl)Oc1ccccc1>>C#Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Oc4ccccc4)c4ccccc34)n2)cc(C(=O)NCCOCCOCCOC)c1,,C1CCOC1,ClCCl,O=C([O-])O.[Na+],,val
US04437878,COC(=O)C1=C(N)CSC1.O=C=NC1CCCCC1>>COC(=O)C1=C(NC(=O)NC2CCCCC2)CSC1,,CC#N,,CCN(CC)CC,Cl,val
US20080096877A1,CCOC(=O)COc1cc(N(C)S(=O)(=O)c2ccccn2)c2[nH]c(C3=NCC(CN4CCSCC4)S3)cc2c1>>CN(c1cc(OCC(=O)O)cc2cc(C3=NCC(CN4CCSCC4)S3)[nH]c12)S(=O)(=O)c1ccccn1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20030225142A1,CCCCC#CCCO.O=C1CCC(=O)N1Br>>CCCCC#CCCBr,,CN(C)C=O,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090170913A1,CN1CCC(N(C)c2nc3cc(N)ccc3o2)CC1.O=C(O)c1ccc(-c2ccc(F)cc2)cc1>>CN1CCC(N(C)c2nc3cc(NC(=O)c4ccc(-c5ccc(F)cc5)cc4)ccc3o2)CC1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20040132727A1,CC(O)c1cccc(Br)c1.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)OC(C)c4cccc(Br)c4)c(C)c3C)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US04833163,CC1(C)C(C=CC(=O)OC2CCC2)C1C(=O)O>>CC(C)COC(=O)C=CC1C(C(=O)O)C1(C)C,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140018393A1,Brc1ccccn1.CCOC(=O)CC1CCNCC1>>CCOC(=O)CC1CCN(c2ccccn2)CC1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20140309193A1,CCOC(=O)c1c(OCC(=O)O)c(OCc2ccccc2)c(C(=O)OCC)n1-c1ccc(OC)cc1.[NH4+]>>CCOC(=O)c1c(OCC(N)=O)c(OCc2ccccc2)c(C(=O)OCC)n1-c1ccc(OC)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05180723,CCOC(C)=N.Nc1ccc(F)cc1N>>Cc1nc2ccc(F)cc2[nH]1,,CCO,,Cl,,val
US20060287343A1,COC(=O)Cc1ccccc1C#C[Si](C)(C)C.N#CS[Pb]SC#N>>C#Cc1ccccc1CC(=O)N=C=S,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20060217372A1,N#Cc1ccc(Cl)nc1.NC(=O)c1ccc(O)cc1>>N#Cc1ccc(Oc2ccc(C(N)=O)cc2)nc1,,Cc1ccccc1,,CC(=O)N(C)C,O=C([O-])[O-].[K+].[K+],val
US20080287453A1,CC(C)(C)OC(=O)N1CCCC(C(=O)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1>>O=C(C1CCCNC1)N1CCN(c2ccc(Cl)c(Cl)c2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06353015B1,CCC(=O)OC(=O)CC.NCCc1c[nH]c2ccc(OCc3ccccc3)cc12>>CCC(=O)NCCc1c[nH]c2ccc(OCc3ccccc3)cc12,,ClCCl,,CCN(CC)CC,Cl,val
US04655816,CCOC(=O)c1c(Cl)cc(C(F)(F)F)nc1C(F)(F)F.Cc1cc(O)ccc1[N+](=O)[O-]>>CCOC(=O)c1c(Oc2ccc([N+](=O)[O-])c(C)c2)cc(C(F)(F)F)nc1C(F)(F)F,,CC(=O)CC(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20140228386A1,Cc1csc2cc(Br)ccc12.O=C1NCCN1c1cnccc1C1CC1>>Cc1csc2cc(N3CCN(c4cnccc4C4CC4)C3=O)ccc12,I[Cu]I,C1COCCO1,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20140336185A1,COc1ccc(CC(=O)Nc2ccc(C(=O)N(CC(=O)OC(C)(C)C)Cc3ccc(O)cc3)cc2)c(C(F)(F)F)c1.O=C(Cl)c1ccc(Br)cc1>>COc1ccc(CC(=O)Nc2ccc(C(=O)N(CC(=O)OC(C)(C)C)Cc3ccc(OC(=O)c4ccc(Br)cc4)cc3)cc2)c(C(F)(F)F)c1,,ClCCl,,,,val
US20070004776A1,CC(C)(C)OC(=O)NC(Cc1ccc(Oc2ccc(C=O)cc2)cc1)C(=O)O.CNC>>CN(C)C(=O)C(Cc1ccc(Oc2ccc(C=O)cc2)cc1)NC(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US04629797,C1=COCCC1.COC(=O)CNC(=O)CC(O)CBr>>COC(=O)CNC(=O)CC(CBr)OC1CCCCO1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20140378459A1,CC(C)(C)OC(=O)C(C)(C)Br.CC(C)(C)OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)[C@H](Cc1ccc(OC(C)(C)C(=O)OC(C)(C)C)cc1)NC(=O)OCc1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110060009A1,CCN(CC)S(F)(F)F.Cc1[nH]c2ccccc2c1C[C@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C>>Cc1[nH]c2ccccc2c1C[C@H]1CC(F)CN1C(=O)OC(C)(C)C,,CCOC(C)=O,,,,val
US20150111870A1,COc1nc2ccc(Br)cc2c(Cl)c1CBr.FC(F)(F)C1CCNCC1>>COc1nc2ccc(Br)cc2c(Cl)c1CN1CCC(C(F)(F)F)CC1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20050075394A1,CC1(C)OCc2cc([C@@H](O)CNCCCCCCOCCOCc3cccc(NC(=O)Nc4cccc(NC(=O)c5cccnc5)c4)c3)ccc2O1>>O=C(Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)Nc1cccc(NC(=O)c2cccnc2)c1,,CC(=O)O,O,,,val
US20100029650A1,CS(=O)(=O)c1ccc(B(O)O)cc1.Nc1cnc(Br)cn1>>CS(=O)(=O)c1ccc(-c2cnc(N)cn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CO,O=C([O-])[O-].[Na+].[Na+],,val
US20160060267A1,CCC(C=O)C(=O)OC.N#Cc1cn[nH]c1N>>CCc1c[nH]c2c(C#N)cnn2c1=O,,CC(=O)O,,,,val
US20050113400A1,COC(=O)c1ccc(COC(C)=O)c(C)c1>>COC(=O)c1ccc(CO)c(C)c1,,CO,,C[O-].[Na+],,val
US20150252030A1,COC(=O)COc1cccnc1-c1ccoc1.NN>>NNC(=O)COc1cccnc1-c1ccoc1,,CCO,,,,val
US20100168418A1,CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCN(CCn2c(=O)ccc3cc([N+](=O)[O-])ccc32)CC1.Cl>>Cl.O=c1ccc2cc([N+](=O)[O-])ccc2n1CCN1CCC(NCc2ccc3c(c2)OCCO3)CC1,,C1COCCO1,,,,val
US20120101064A1,CC(C)(C)OC(=O)N1CCN(c2ccc3ncn(C(=O)OC(C)(C)C)c3n2)CC1.COC(=O)c1ccc(C#N)c(-c2cncc3ccccc23)c1>>CC(C)(C)OC(=O)N1CCN(c2ccc3nc(C(=O)c4ccc(C#N)c(-c5cncc6ccccc56)c4)[nH]c3n2)CC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20060223709A1,Cn1[nH]c(=O)cc1C(F)(F)F.O=[N+]([O-])c1cc(F)cc(Oc2cccc(C(F)(F)F)c2)c1>>Cn1nc(Oc2cc(Oc3cccc(C(F)(F)F)c3)cc([N+](=O)[O-])c2)cc1C(F)(F)F,,CC(=O)N(C)C,,O,[H-].[Na+],val
US04282246,O=C(O)c1coc(Br)c1.Sc1ccccc1Cl>>O=C(O)c1coc(Sc2ccccc2Cl)c1,,CN(C)C=O,,,,val
US04638060,CC(C)(C)OC(=O)NC(C(=O)NOCc1ccccc1)C1(O)CCCC1>>CC(C)(C)OC(=O)NC1C(=O)N(OCc2ccccc2)C12CCCC2,,c1ccncc1,,,,val
US04507498,CCCc1c(O)c(Cl)cc(C(C)=O)c1O.CCCc1c(OCCCC(=O)OCC)ccc(C(C)=O)c1OCCCOCCCBr>>CCCc1c(O)c(C(C)=O)cc(Cl)c1OCCCOCCCOc1c(C(C)=O)ccc(OCCCC(=O)OCC)c1CCC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160158207A1,CC(C)(C)OC(=O)N1CCc2[nH]nc(Br)c2C1.CS(=O)(=O)OC1CCOCC1>>CC(C)(C)OC(=O)N1CCc2c(c(Br)nn2C2CCOCC2)C1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080085910A1,COC(=O)C(C/C=C/c1ccc(C2(OC)CCOCC2)cc1)NC(=O)c1c(Cl)cccc1Cl>>COC1(c2ccc(/C=C/CC(NC(=O)c3c(Cl)cccc3Cl)C(=O)O)cc2)CCOCC1,,C1CCOC1,,[Na+].[OH-],,val
US20040209948A1,CON(C)C(=O)c1ccc(S(=O)(=O)NC2CCN(Cc3ccccc3)CC2)c2ccccc12.C[Mg]Br>>CC(=O)c1ccc(S(=O)(=O)NC2CCN(Cc3ccccc3)CC2)c2ccccc12,,C1CCOC1,,,,val
US07026336B1,COCCN1CCC(C=O)CC1>>COCCN1CCC(C=O)CC1,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20150152047A1,BrC(Br)(Br)Br.CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CO)c(C(F)(F)F)c1>>CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CBr)c(C(F)(F)F)c1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05688803,O=[N+]([O-])O.O=c1[nH]c(=O)c2ccc(Cl)cc2[nH]1>>O=c1[nH]c(=O)c2cc([N+](=O)[O-])c(Cl)cc2[nH]1,,O=S(=O)(O)O,,,,val
US20110166164A1,Clc1ncnc2scnc12.NCCc1ccc(O)cc1>>Oc1ccc(CCNc2ncnc3scnc23)cc1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20030134848A1,CC1CN=C(N)S1.Clc1ccc(CCBr)cn1>>Cc1cn(CCc2ccc(Cl)nc2)c(=N)s1,,CC#N,,,,val
US20060154974A1,CC(C)(C)CC(=O)Nc1c(Cl)cc(C(=O)O)cc1Cl.Nc1nccs1>>CC(C)(C)CC(=O)Nc1c(Cl)cc(C(=O)Nc2nccs2)cc1Cl,,CN(C)C=O,ClCCCl,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20080176881A1,CC(C)Oc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)C(=O)N(C1CCNCC1)C2.CCOC(=O)Cl>>CCOC(=O)N1CCC(N2Cc3cc(OC(C)C)c(Nc4ncc(Cl)c(Nc5ccccc5S(=O)(=O)C(C)C)n4)cc3C2=O)CC1,,CN(C)C=O,,CCN(CC)CC,,val
US20110071197A1,COC(=O)c1cc(Oc2ccc(N)nc2)ccc1Nc1ccc(F)c(F)c1.Cc1c(Cl)cccc1S(=O)(=O)Cl>>COC(=O)c1cc(Oc2ccc(NS(=O)(=O)c3cccc(Cl)c3C)nc2)ccc1Nc1ccc(F)c(F)c1,,c1ccncc1,,,,val
US20080261952A1,C1CCNC1.O=[N+]([O-])c1ccc(F)c(F)c1>>O=[N+]([O-])c1ccc(N2CCCC2)c(F)c1,,CCOC(C)=O,,CCN(CC)CC,,val
US20090163488A1,CCOC(=O)N=C=S.Cc1cc(C(=O)Nc2cccc(Oc3ccc(N)nc3)c2)n(C)n1>>CCOC(=O)NC(=S)Nc1ccc(Oc2cccc(NC(=O)c3cc(C)nn3C)c2)cn1,,CS(C)=O,O,,,val
US20130317057A1,CN.CS(=O)(=O)Nc1ccc(F)c([N+](=O)[O-])c1>>CNc1ccc(NS(C)(=O)=O)cc1[N+](=O)[O-],,CS(C)=O,,CC(=O)[O-].[Na+],,val
US06043260,CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C.CS(=O)(=O)O>>CCC(CC)Oc1cc(C)[nH+]c(Oc2c(C)cc(C)cc2C)c1C.CS(=O)(=O)[O-],,CCOC(C)=O,,,,val
US20040157866A1,CCOC(=O)C=CN(C)C.O=C(Cl)c1ccc(C(F)(F)F)cc1>>CCOC(=O)/C(=C/N(C)C)C(=O)c1ccc(C(F)(F)F)cc1,,C1CCOC1,O,CCN(CC)CC,CCOC(C)=O,val
US20100174080A1,O=C1c2cccc3c2C(CCC3)CN1C1CN2CCC1CC2>>O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2,,CCO,,Br,,val
US20050245595A1,Cn1c(C(=O)O)cc2c(OCc3ccccc3)cccc21.O=S(Cl)Cl>>Cn1c(C(=O)Cl)cc2c(OCc3ccccc3)cccc21,,c1ccccc1,,,,val
US20100234351A1,CC(C)CO[C@H]1CCN(C(=O)OC(C)(C)C)C1.Cl>>CC(C)CO[C@H]1CCNC1.Cl,,C1CCOC1,,,,val
US20140030189A1,CC(C)(C)OC(=O)NC(=N)NC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)Oc1ccc(CO)cc1Br>>CC(C)(C)OC(=O)NC(=N)N(Cc1ccc(O[Si](C)(C)C(C)(C)C)c(Br)c1)C(=O)OC(C)(C)C,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060142265A1,CN(C)CCN1Cc2cc(/C=C/C(=O)OC(C)(C)C)cnc2NC1=O.Cl>>CN(C)CCN1Cc2cc(/C=C/C(=O)O)cnc2NC1=O.Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110071175A1,COC(=O)Cn1c(C)cc2cc(F)ccc21.O=Cc1sccc1Sc1ccncc1>>COC(=O)Cn1c(C)c(Cc2sccc2Sc2ccncc2)c2cc(F)ccc21,,ClCCCl,ClCCl,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20110281865A1,COC(=O)c1cccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)c1>>O=C(O)c1cccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)c1,,CO,O,Cl,[Li+].[OH-],val
US20100298324A1,COc1cnc(-n2c(=S)[nH]c3cc(C(=O)O)cc(Cl)c3c2=O)nc1OC.NCc1ccc(Cl)cc1>>COc1cnc(-n2c(=S)[nH]c3cc(C(=O)NCc4ccc(Cl)cc4)cc(Cl)c3c2=O)nc1OC,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04226768,CC=O.[O-][N+]1=C(c2ccccc2F)c2cc(Cl)ccc2NC(C(=NO)N2CCOCC2)C1>>Cc1nc(N2CCOCC2)c2n1-c1ccc(Cl)cc1C(c1ccccc1F)=[N+]([O-])C2,,CC(=O)O,,N,,val
US20140228386A1,Brc1ccc2ccsc2c1.O=S(=O)(c1ccccc1)N(F)S(=O)(=O)c1ccccc1>>Fc1cc2ccc(Br)cc2s1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20080262042A1,CN(Cc1cn(S(=O)(=O)c2ccco2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C.Cl>>CNCc1cn(S(=O)(=O)c2ccco2)c(-c2cccnc2F)c1F.Cl,,CC(C)O,CCOC(C)=O,,,val
US20070249670A1,Nc1cc2ccccc2cc1C(=O)O.O=C=Nc1c(Cl)cccc1Cl>>O=C(Nc1cc2ccccc2cc1C(=O)O)Nc1c(Cl)cccc1Cl,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20030036557A1,Cc1ncccc1C1=NC(C(F)(F)F)CN1c1ccc(S(=O)(=O)n2c(C)ccc2C)cc1>>Cc1ncccc1-c1nc(C(F)(F)F)cn1-c1ccc(S(N)(=O)=O)cc1,,O,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],,val
US03946025,CCCC(Cl)CBr.Sc1ccccc1Br>>CCCC(Cl)CSc1ccccc1Br,,CCO,,[Na],,val
US20100069457A1,CCOC(=O)Cc1ccc(N2C(=O)c3c(c(OCC)c4ccccc4c3O)C2=O)c(F)c1.O=S(=O)(OCC(F)F)C(F)(F)F>>CCOC(=O)Cc1ccc(N2C(=O)c3c(c(OCC(F)F)c4ccccc4c3OCC)C2=O)c(F)c1,,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US04766133,Cc1cnc(CCl)c(C)c1.FC(F)(F)c1ccc2nc(S)[nH]c2c1>>Cc1cnc(CSc2nc3ccc(C(F)(F)F)cc3[nH]2)c(C)c1,,O,,Cl,[Na+].[OH-],val
US20160168139A1,CI.COc1ccc(COc2cc(N3CCOCC3)cc(-c3cccc4c3Sc3ccc(NC(=O)OC(C)(C)C)cc3C4)n2)cc1>>COc1ccc(COc2cc(N3CCOCC3)cc(-c3cccc4c3Sc3ccc(N(C)C(=O)OC(C)(C)C)cc3C4)n2)cc1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US05162370,CCCCC(F)C(O)CC[C@H]1[C@H](OC2CCCCO2)C[C@@H]2C/C(=C\CCCC(=O)OC)C[C@@H]21>>CCCCC(F)C(O)CC[C@H]1[C@H](OC2CCCCO2)C[C@@H]2C/C(=C\CCCC(=O)O)C[C@@H]21,,CO,,[Na+].[OH-],,val
US04197298,CON=C(C(=O)OC)c1csc(N)n1.O=C(Cl)CCl>>CON=C(C(=O)OC)c1csc(NC(=O)CCl)n1,,CC(=O)N(C)C,,O,,val
US04051248,CN(C)CC1CCc2ccccc2C1=O.NC(=O)C1(Nc2ccccc2)CCNCC1>>NC(=O)C1(Nc2ccccc2)CCN(CC2CCc3ccccc3C2=O)CC1,,CCO,,Cl,,val
US20130281490A1,CC(C)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C(=O)[O-]>>CC(C)[C@H](O)[C@@H](N)C(=O)O,,Cl,,,,val
US20150210677A1,NC1=C(O)C(=O)C(c2ccccc2Cl)O1.O=S(=O)(Cl)Cc1ccccc1>>NC1=C(OS(=O)(=O)Cc2ccccc2)C(=O)C(c2ccccc2Cl)O1,,C1CCOC1,,CCN(CC)CC,[Cl-].[NH4+],val
US20070191373A1,CCCCCCc1cc2c[nH]c(=O)nc2o1.ClCc1ccccc1>>CCCCCCc1cc2cnc(OCc3ccccc3)nc2o1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100324068A1,Cc1nc(C)c(-c2ccc(O)cc2)nc1C(N)=O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1nc(C)c(-c2ccc(OS(=O)(=O)C(F)(F)F)cc2)nc1C(N)=O,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20080027090A1,NN1CCc2ccccc21.O=C1CCCCCC1>>c1cc2c3c(c1)c1c(n3CC2)CCCCC1,,O,,O=S(=O)(O)O,,val
US20070249642A1,COC(CCn1cc(-c2cccnc2Cl)c(=O)[nH]c1=O)OC>>O=CCCn1cc(-c2cccnc2Cl)c(=O)[nH]c1=O,,C1CCOC1,,,,val
US20040166432A1,BrBr.CCCCCCOc1ccc(C)cc1OCCCCCC>>CCCCCCOc1cc(C)c(Br)cc1OCCCCCC,,ClCCl,,O,,val
US20120172351A1,COC(=O)C[C@@H]1COc2cc(NCc3cccc(-c4c(C)nc(OC(F)F)nc4C)c3C)ccc21>>Cc1nc(OC(F)F)nc(C)c1-c1cccc(CNc2ccc3c(c2)OC[C@H]3CC(=O)O)c1C,,C1CCOC1,CO,[Na+].[OH-],,val
US20020072621A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CCl>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H]1CO1,,CC(C)O,,[Na+].[OH-],,val
US07115611B2,CCOC(=O)C(C)(C)Oc1ccc(OCc2c(C)nc(-c3ccc(C(F)(F)F)cc3)nc2CCOC)cc1C>>COCCc1nc(-c2ccc(C(F)(F)F)cc2)nc(C)c1COc1ccc(OC(C)(C)C(=O)O)c(C)c1,,C1CCOC1,CCOCC,[Li+].[OH-],,val
US04412077,CC(=O)C1=C(C)NC(=O)CC1>>CC(=O)c1ccc(=O)[nH]c1C,[Pd],,,,,val
US05580985,CCOC(=O)Cn1cc(-c2ccc(F)cc2)c(-c2ccc(S(C)(=O)=O)cc2)n1>>CS(=O)(=O)c1ccc(-c2nn(CC(=O)O)cc2-c2ccc(F)cc2)cc1,,C1CCOC1,,Cl,[Li+].[OH-],val
US05236952,COc1cc(C(O)c2ccccc2)cc([N+](=O)[O-])c1OC>>COc1cc(C(=O)c2ccccc2)cc([N+](=O)[O-])c1OC,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20060128790A1,C=CC(=O)O.Cc1cc(O)c(C)c(C)c1O>>Cc1c(C)c2c(c(C)c1O)CCC(=O)O2,,CS(=O)(=O)O,,,,val
US20140021407A1,COCP(Cl)(c1ccccc1)(c1ccccc1)c1ccccc1.O=C1CCC(C2CCC(c3cc(F)c(F)c(F)c3)CC2)CC1>>COC=C1CCC(C2CCC(c3cc(F)c(F)c(F)c3)CC2)CC1,,O,,C1CCOC1,CC(C)(C)[O-].[K+],val
US20040067933A1,CCCCC1(CC)CN(c2ccccc2)c2cc(Br)c(OCC(=O)OCC)cc2S(=O)(=O)C1>>CCCCC1(CC)CN(c2ccccc2)c2cc(Br)c(OCC(=O)O)cc2S(=O)(=O)C1,,CCO,,CC(=O)O,[Na+].[OH-],val
US06239131B1,CCOC(=O)c1cccc(N)c1.Cc1ccc2c(c1)N(CC(=O)c1ccc(C)o1)C(=O)C(N)CN2C(=O)C(C)(C)C.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCOC(=O)c1cccc(NC(=O)NC2CN(C(=O)C(C)(C)C)c3ccc(C)cc3N(CC(=O)c3ccc(C)o3)C2=O)c1,,C1CCOC1,O,CCN(CC)CC,,val
US20090298823A1,Cc1ccc(S(=O)(=O)n2ccc3c(NC4CCN(C(=O)OC(C)(C)C)CC4)nc(Cl)nc32)cc1.NC(=O)c1ccc(N)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c(NC4CCNCC4)nc(Nc4ccc(C(N)=O)cc4)nc32)cc1,,CCCCO,,C[Si](C)(C)Cl,,val
US05272270,CNCC(OC)OC.COc1ccc([C@@H]2O[C@H]2c2ccc(OC)c(OCc3ccccc3)c2)cc1OCc1ccccc1>>COc1ccc([C@H](O)[C@@H](c2ccc(OC)c(OCc3ccccc3)c2)N(C)CC(OC)OC)cc1OCc1ccccc1,,CCC(C)O,,ClCCl,,val
US20040106604A1,Cc1cccc(-c2nn3c(c2-c2ccc(F)cc2)CC[C@H]3COCc2ccccc2)n1>>Cc1cccc(-c2nn3c(c2-c2ccc(F)cc2)CC[C@H]3CO)n1,,CO,ClC(Cl)Cl,C[Si](C)(C)I,,val
US03992546,CC(O)(c1ccc(F)cc1)C1CCNCC1.O=C(CCCCl)c1ccc(F)cc1>>CC(O)(c1ccc(F)cc1)C1CCN(CCCC(=O)c2ccc(F)cc2)CC1,,CC(=O)CC(C)C,,[I-].[Na+],,val
US20130184294A1,CC(C)Nc1nc2c(C(F)(F)F)cccn2c(=O)c1NC(=O)CC(C)(C)C>>CC(C)Nc1nc2n(c(=O)c1NC(=O)CC(C)(C)C)CCCC2C(F)(F)F,[Pd],CCO,,,,val
US20040048916A1,CS(=O)(=O)c1ccc2c(c1)C(=O)N(CC(F)(F)F)C2=O>>CS(=O)(=O)c1ccc2c(c1)C(O)N(CC(F)(F)F)C2=O,,O,,CO,,val
US20070191416A1,C1CCOC1.CCOC(=O)Cn1c2c(c3ccccc31)CN(C(=O)c1ccccc1)CC2>>O=C(O)Cn1c2c(c3ccccc31)CN(C(=O)c1cccc3ccccc13)CC2,,C1CCOC1,O,[Na+].[OH-],,val
US20160068535A1,COc1cc(C2CCN(C(=O)OC(C)(C)C)CC2(F)F)ccc1[N+](=O)[O-]>>COc1cc(C2CCN(C(=O)OC(C)(C)C)CC2(F)F)ccc1N,[Pd],CO,,,,val
US20110218193A1,COCn1c(=O)c2c(c3ccc(CO)cc31)NCCC2.O=S(Cl)Cl>>COCn1c(=O)c2c(c3ccc(CCl)cc31)NCCC2,,ClCCl,,O=C([O-])O.[Na+],,val
US20050137203A1,CC(C)(C)OC(=O)Nc1ccc(-c2cnc(OC3CN4CCC3CC4)nc2)cc1>>Nc1ccc(-c2cnc(OC3CN4CCC3CC4)nc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100305133A1,COC(=O)c1c(OC)ccc([N+](=O)[O-])c1N.O=C(C(=O)c1ccccc1)c1ccccc1>>COC(=O)c1c(OC)ccc2nc(-c3ccccc3)c(-c3ccccc3)nc12,[Pd],CCOC(C)=O,,,,val
US20100292143A1,CCOC(=O)c1ccc[nH]1.O=C(Cl)C1CCCC1>>CCOC(=O)c1cc(C(=O)C2CCCC2)c[nH]1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05883114,Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCCCN=[N+]=[N-])c4c21)C(=O)NC3=O>>Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCCCN)c4c21)C(=O)NC3=O,[Pd],C1CCOC1,CCO,,,val
US20080009509A1,C=CC(=O)Cl.COCCCOc1cc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)[C@H](C)N>>C=CC(=O)N[C@@H](C)C(=O)Nc1cc2c(Nc3ccc(OCc4ccccn4)c(Cl)c3)ncnc2cc1OCCCOC,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20140221335A1,CSc1cc(Br)ccc1C(N)C1=C(Nc2cccc(C(F)(F)F)c2)CCC1=O.O=C(n1ccnc1)n1ccnc1>>CSc1cc(Br)ccc1C1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)CC2,,CC#N,,CCN(CC)CC,Cl,val
US20080009530A1,CCOC(=O)/C=C/c1ccc(OCCOC)cc1O.Fc1ccc(C(F)(F)F)cc1Cl>>CCOC(=O)/C=C/c1ccc(OCCOC)cc1Oc1ccc(C(F)(F)F)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04613691,COC(=O)C(N)Cc1ccccc1>>N[C@@H](Cc1ccccc1)C(=O)O,,O,,CCOC(C)=O,[Na+].[OH-],val
US20070225366A1,C[C@H](COC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)OC(C)(C)C)OC(=O)c1ccccc1.Cl>>C[C@H](COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1)OC(=O)c1ccccc1.Cl,,C1COCCO1,,,,val
US20060258714A1,Cc1ccc(S(=O)(=O)OC[C@H]2C=Cc3ccc(F)c(-c4ccc(Cl)cc4C)c3O2)cc1>>Cc1ccc(S(=O)(=O)OC[C@H]2CCc3ccc(F)c(-c4ccc(Cl)cc4C)c3O2)cc1,O=[Pt]=O,CCO,CCOC(C)=O,,,val
US20150368228A1,CC1(C)OB(c2ccc(S(=O)(=O)NC34CC5CC(CC(C5)C3)C4)nc2)OC1(C)C.Nc1nc(Nc2cc(Cl)c(Br)c(C(F)(F)F)c2)n[nH]1>>Nc1nc(Nc2cc(Cl)c(-c3ccnc(S(=O)(=O)NC45CC6CC(CC(C6)C4)C5)c3)c(C(F)(F)F)c2)n[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20070032518A1,CC(C)(C(N)=S)S(=O)(=O)c1ccccc1.COc1ccc2cc(-c3csc(CSc4ccccc4)n3)c(=O)[nH]c2c1>>COc1ccc2cc(-c3csc(C(C)(C)S(=O)(=O)c4ccccc4)n3)c(=O)[nH]c2c1,,CO,,,,val
US20060135578A1,CCOC(=O)/C=C/c1nc(COc2ccc(CCl)cc2OC)c(C)o1.O=Cc1cn(-c2ccccc2)nc1O>>CCOC(=O)/C=C/c1nc(COc2ccc(COc3nn(-c4ccccc4)cc3C=O)cc2OC)c(C)o1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160031879A1,CCOCCc1cc(C(=O)OCC)c2c(Cl)cccn12>>CCOCCc1cc(C(=O)O)c2c(Cl)cccn12,,CO,,[Na+].[OH-],,val
US05409943,Nc1ncccc1OCc1c(F)cccc1Cl.O=[N+]([O-])c1ccc(N=C=S)cc1>>O=[N+]([O-])c1ccc(NC(=S)Nc2ncccc2OCc2c(F)cccc2Cl)cc1,,CCOCC,,Cc1ccccc1,,val
US20080306082A1,C[C@H]1CN(C(c2ccccc2)c2ccccc2)C[C@@H](C)N1.O=C1c2ccccc2C(=O)N1CCCBr>>C[C@H]1CN(C(c2ccccc2)c2ccccc2)C[C@@H](C)N1CCCN1C(=O)c2ccccc2C1=O,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20140349972A1,CCOP(=O)(OCC)c1ccc(C(N)c2ccccc2)cc1.O=C(O)c1cnc(-c2cccnn2)nc1O>>CCOP(=O)(OCC)c1ccc(C(NC(=O)c2cnc(-c3cccnn3)nc2O)c2ccccc2)cc1,,CC#N,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20140135332A1,CCOC(C)=O.COc1ccc(-c2nc(C(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)Oc3ccc(F)c(C(N)=O)c3F)c(Br)o2)cc1>>C=Cc1oc(-c2ccc(OC)cc2)nc1C(CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)Oc1ccc(F)c(C(N)=O)c1F,,CCOC(C)=O,O,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US20120094996A1,COc1ccc(-c2nn3ccnc3s2)cc1OC.O=C1CCC(=O)N1I>>COc1ccc(-c2nn3c(I)cnc3s2)cc1OC,,CN(C)C=O,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20130252944A1,COc1ccc(Cn2cc3c(n2)C(O)CCc2sc(Nc4nccc(C)n4)nc2-3)cc1>>Cc1ccnc(Nc2nc3c(s2)CCC(O)c2n[nH]cc2-3)n1,,O=C(O)C(F)(F)F,,,,val
US20150119373A1,CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C5(C)CC5)CC[C@]4(C(=O)N4CCC(OCCN5CCOCC5)CC4)CC[C@]23C)C1(C)C>>CC1([C@@H]2CC[C@]3(C(=O)N4CCC(OCCN5CCOCC5)CC4)CC[C@]4(C)[C@H](CC[C@@H]5[C@@]6(C)CC[C@H](O)C(C)(C)[C@@H]6CC[C@]54C)[C@@H]23)CC1,,C1CCOC1,ClCCl,CO,,val
US20140275064A1,CN(C)/C=N/c1ccc2nc(C#N)sc2c1C#N.Nc1ccc(O)cc1>>N#Cc1nc2ccc3ncnc(Nc4ccc(O)cc4)c3c2s1,,CCOC(C)=O,,[Br-].[K+],,val
US20120028931A1,CC(C)(C)OC(=O)N1CCC(=CC(=O)Cl)CC1.NC(=NO)c1ccccc1>>CC(C)(C)OC(=O)N1CCC(=Cc2nc(-c3ccccc3)no2)CC1,,C1COCCO1,,O,,val
US20100120760A1,COC(=O)c1c(-c2ccc(F)cc2)oc2ccc3c(c12)CC(COC(C)=O)O3.O=[N+]([O-])O>>COC(=O)c1c(-c2ccc(F)cc2)oc2cc([N+](=O)[O-])c3c(c12)CC(COC(C)=O)O3,,ClC(Cl)Cl,,,,val
US05877317,NC(=O)c1ccc(N2CCN(CCC3CCc4ccccc43)CC2)cc1>>N#Cc1ccc(N2CCN(CCC3CCc4ccccc43)CC2)cc1,,CN(C)C=O,,O=P(Cl)(Cl)Cl,,val
US20110053952A1,CC(C)(C)OC(=O)N1CCNCC1.COc1ccc(-c2cnc(Nc3ccc(C(=O)O)nc3)nc2)cc1>>COc1ccc(-c2cnc(Nc3ccc(C(=O)N4CCN(C(=O)OC(C)(C)C)CC4)nc3)nc2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160222033A1,CCN(Cc1cc(=O)n2c(C(C)=O)c(C)sc2n1)c1ccc(F)cc1.C[Mg]Br>>CCN(Cc1cc(=O)n2c(C(C)(C)O)c(C)sc2n1)c1ccc(F)cc1,,C1CCOC1,,,,val
US20140228357A1,CI.CN1CCN(C(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)CC1>>C[N+]1(C)CCN(C(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)CC1.[I-],,CCOCC,,,,val
US05101411,CC(=O)c1cccc2ccccc12.O=Cc1cccc2ccccc12>>O=C(Cc1cccc2ccccc12)C(O)c1cccc2ccccc12,,CCO,,[Na+].[OH-],,val
US20140121206A1,COc1ccc(CN2CC3(CCCC(COCc4ccccc4)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cc1>>N#Cc1ccc2ncn(CC3(COCc4ccccc4)CCCC4(CNC(=O)O4)C3)c2c1,,CC#N,,CCOC(C)=O,[Na+].[OH-],val
US04977155,Cn1nnc2ccc(N)c(N)c21.O=C(O)C(=O)O>>Cn1nnc2ccc3nc(O)c(O)nc3c21,,Cl,,O,O,val
US20070082880A1,COC(=O)c1cc2c(Cl)c(C#N)cnc2s1.Cc1c(N)ccc2[nH]ccc12>>COC(=O)c1cc2c(Nc3ccc4[nH]ccc4c3C)c(C#N)cnc2s1,,CO,,,,val
US20040259907A1,CNCC(O)c1cc2ccccc2o1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)oc21>>CN(Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2o1)CC(O)c1cc2ccccc2o1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20130109661A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.CC1CCCN1c1cccc(Nc2cc(-c3cccc(CN)c3)nn3ccnc23)n1>>CC1CCCN1c1cccc(Nc2cc(-c3cccc(CNC4CCN(C(=O)OC(C)(C)C)CC4)c3)nn3ccnc23)n1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120029226A1,CC(C(=O)O)c1ccc(-c2ccccc2)c(F)c1.c1ccc(CNCc2ccccc2)cc1>>CC(C(=O)O)c1ccc(-c2ccccc2)c(F)c1.c1ccc(CNCc2ccccc2)cc1,,CCO,,,,val
US20120289526A1,CC[C@@H](NC(=O)OC(C)(C)C)C(=O)O.COc1cc(Oc2ccc(N)cn2)ccc1C>>CC[C@@H](N)C(=O)Nc1ccc(Oc2ccc(C)c(OC)c2)nc1,,CCOC(C)=O,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US04717724,COc1ccc2c(c1)CCN(c1ccc(Cl)cc1)C2>>Oc1ccc2c(c1)CCN(c1ccc(Cl)cc1)C2,,Br,CC(=O)O,,,val
US20130252934A1,CC(C)(C)[Si](C)(C)Cl.OCC[C@H](O)c1ccc(Cl)c(F)c1>>CC(C)(C)[Si](C)(C)OCC[C@H](O)c1ccc(Cl)c(F)c1,,ClCCl,,c1c[nH]cn1,,val
US20100130464A1,Cc1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1B(O)O.N#Cc1ccc(Cl)nc1>>Cc1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1-c1ccc(C#N)cn1,,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20140107078A1,CCOC(=O)CBr.CCOc1cc(C=O)ccc1O>>CCOC(=O)COc1ccc(C=O)cc1OCC,,CC(C)=O,,CCO,O=C([O-])[O-].[K+].[K+],val
US20060025459A1,CCn1ncc2c([N+](=O)[O-])cc(C(=O)OC)cc21>>CCn1ncc2c(N)cc(C(=O)OC)cc21,[Pd],CO,O,,,val
US20100292208A1,CCOC(=O)c1coc2cc(O)ccc12>>OCc1coc2cc(O)ccc12,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20060111349A1,CCCC[Sn](CCCC)(CCCC)c1c(OC)c(=O)c1=O.O=C(Nc1cccc(I)c1)c1sccc1NCc1ccnc2ccccc12>>COc1c(-c2cccc(NC(=O)c3sccc3NCc3ccnc4ccccc34)c2)c(=O)c1=O,I[Cu]I,ClCCl,,CCOC(C)=O,,val
US04619937,O=C1CCC2CCCC3CCC(=O)N1C23.OCc1ccccc1>>O=C1CCC2CCCC(CCC(=O)OCc3ccccc3)C2N1,Cl,,,,,val
US20080032967A1,CSc1nccc(Oc2ccc(N)c3ccccc23)n1.Cc1cc(F)ccc1-c1cccc(C(=O)O)c1>>CSc1nccc(Oc2ccc(NC(=O)c3cccc(-c4ccc(F)cc4C)c3)c3ccccc23)n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160038504A1,CCOc1nnc(Cl)cc1N1CCOCC1.Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1B1OC(C)(C)C(C)(C)O1>>CCOc1nnc(-c2cc(NC(=O)c3ccnc(C(C)(C)C#N)c3)ccc2C)cc1N1CCOCC1,,COCCOC,,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20090118282A1,C[C@H]1CN(Cc2ccc(O)cc2)C[C@@H](C)O1.FC(F)(F)c1ccc2c(SCCCCCBr)ccnc2c1>>C[C@H]1CN(Cc2ccc(OCCCCCSc3ccnc4cc(C(F)(F)F)ccc34)cc2)C[C@@H](C)O1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040082784A1,CNC.O=[N+]([O-])c1cc(F)c(F)cc1Cl>>CN(C)c1cc(Cl)c([N+](=O)[O-])cc1F,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20080027067A1,Nc1nccs1.O=C(N1CCC(c2ccc(S(=O)(=O)Cl)cc2)CC1)C(F)(F)F>>O=C(N1CCC(c2ccc(S(=O)(=O)Nc3nccs3)cc2)CC1)C(F)(F)F,,c1ccncc1,,,,val
US05217976,CCc1cc2[nH]c(=O)ccc2c(CC)n1.COC(=O)c1ccc(CBr)cc1>>CCc1cc2c(ccc(=O)n2Cc2ccc(C(=O)OC)cc2)c(CC)n1,,CN(C)C=O,,O,[H-].[Na+],val
US04465850,CC1(C2CCCC2)Cc2cc(O)c(Cl)c(Cl)c2C1=O.CCOC(=O)CCCBr>>CCC(Oc1cc2c(c(Cl)c1Cl)C(=O)C(C)(C1CCCC1)C2)C(=O)O,,CN(C)C=O,,,,val
US20130289031A1,CC(C)OCCOS(C)(=O)=O.CC1(C)CCn2c(nc(Cl)cc2=O)N1>>CC(C)OCCN1c2nc(Cl)cc(=O)n2CCC1(C)C,,CC#N,CCOC(C)=O,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20140128360A1,CCN.CS(=O)(=O)c1cc(F)cc(OCCBr)c1>>CCNCCOc1cc(F)cc(S(C)(=O)=O)c1,,CCO,,Cl,,val
US20110306607A1,COc1cc(C(=O)N2CCC3(CC2)Oc2cc(Cl)ccc2-n2cccc23)ccc1Br.OB(O)C1CC1>>COc1cc(C(=O)N2CCC3(CC2)Oc2cc(Cl)ccc2-n2cccc23)ccc1C1CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070191340A1,O=Cc1ccc(Br)cc1.c1ccc(C2CNCCO2)cc1>>Brc1ccc(CN2CCOC(c3ccccc3)C2)cc1,,C1CCOC1,,Cl,,val
US20040116328A1,Cn1c(=O)c2c(ncn2-c2ccccc2Cl)n(COC(=O)C(C)(C)C)c1=O.O=C1CCC(=O)N1Cl>>Cn1c(=O)c2c(nc(Cl)n2-c2ccccc2Cl)n(COC(=O)C(C)(C)C)c1=O,,CCOC(C)=O,CN(C)C=O,,,val
US06147090,CCOC(=O)N1c2cc(CO)c(OC)cc2[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)OC)C[C@@H]1C.CI>>CCOC(=O)N1c2cc(COC)c(OC)cc2[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)OC)C[C@@H]1C,,CN(C)C=O,,O,[H-].[Na+],val
US20140120118A1,COc1cc2c(cc1OCCCOc1cc3c(cc1OC)C(=O)N1C=C(c4ccc(NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)OCC5c6ccccc6-c6ccccc65)C(C)C)cc4)C[C@H]1C=N3)N=C[C@@H]1CC(c3ccc(N4CCN(C)CC4)cc3)=CN1C2=O>>COc1cc2c(cc1OCCCOc1cc3c(cc1OC)C(=O)N1C=C(c4ccc(N5CCN(C)CC5)cc4)C[C@@H]1C=N3)N=C[C@H]1CC(c3ccc(NC(=O)[C@H](C)NC(=O)[C@@H](N)C(C)C)cc3)=CN1C2=O,,CN(C)C=O,ClCCl,C1CCNCC1,,val
US20110009396A1,CC1=C2[C@@](C)(CCC1)CCC1(O)C(CNCC3C(=O)O[C@H]4C5=C(C)CCC[C@]5(C)CCC34O)C(=O)O[C@@]21C.CCN=C=S>>CCNC(=S)N(CC1C(=O)O[C@H]2C3=C(C)CCC[C@]3(C)CCC12O)CC1C(=O)O[C@@H]2C3=C(C)CCC[C@@]3(C)CCC12O,,C1CCOC1,,,,val
US20090062317A1,CC(=O)Nc1cccc(C2CCN(CCC#N)CC2)c1>>CC(=O)Nc1cccc(C2CCN(CCCN)CC2)c1,[Ni],CO,N,,,val
US20070054935A1,CCOC(=O)c1cnc2cc(C(F)(F)F)ccc2c1OS(=O)(=O)C(F)(F)F.OB(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CCOC(=O)c1cnc2cc(C(F)(F)F)ccc2c1-c1cc(C(F)(F)F)cc(C(F)(F)F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20150246923A1,COc1cnc([N+](=O)[O-])c(N)c1.O=C1CCC(=O)N1Br>>COc1cc(N)c([N+](=O)[O-])nc1Br,,CN(C)C=O,,O,,val
US20130005710A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc(C2CNCCN2)cc1>>COc1ccc(C2CN(C(=O)OC(C)(C)C)CCN2)cc1,,Cc1ccccc1,,C1CCOC1,,val
US20110112074A1,CCc1c(N2CCOCC2=O)cccc1S(=O)(=O)Cl.COC(=O)[C@@H](N)Cc1cc(-c2ccc(Cl)s2)on1>>CCc1c(N2CCOCC2=O)cccc1S(=O)(=O)N[C@@H](Cc1cc(-c2ccc(Cl)s2)on1)C(=O)OC,,ClCCl,,CCN(C(C)C)C(C)C,,val
US03931302,CI.Cc1cccc(C(=O)c2ccc(Cl)cc2)c1O>>COc1c(C)cccc1C(=O)c1ccc(Cl)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05066679,C=CC(=O)Cl.CC(C)(C)c1cc(S)cc(C(C)(C)C)c1O.NCC(=O)c1ccccc1>>CC(C)(C)c1cc(SCCC(=O)NCC(=O)c2ccccc2)cc(C(C)(C)C)c1O,,ClCCl,,CCN(CC)CC,Cl,val
US20080249091A1,Cl[Cu].Nc1ccc(Br)cc1OC(F)(F)F>>FC(F)(F)Oc1cc(Br)ccc1Cl,Cl[Cu],O,,Cl,O=N[O-].[Na+],val
US20100261687A1,COC(=O)c1cc(NC(=O)C2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)cc(-c2nnnn2C)c1>>Cc1cc(CN2CCC(N3C(=O)CCC3C(=O)Nc3cc(C(=O)O)cc(-c4nnnn4C)c3)CC2)ccc1Cl,,CO,,[Na+].[OH-],,val
US04031226,C1CN1.O=C(Cl)c1ccc(F)cc1[N+](=O)[O-]>>O=C(c1ccc(F)cc1[N+](=O)[O-])N1CC1,,ClC(Cl)Cl,,[Na+].[OH-],,val
US04772704,CN(C)Cc1cc(CSCCN)cs1.CSc1ncc([N+](=O)[O-])c(O)n1>>CN(C)Cc1cc(CSCCNc2ncc([N+](=O)[O-])c(=O)[nH]2)cs1,,CCO,,,,val
US20090186891A1,COc1ccc(-c2nnc(-c3ccc(N)c([N+](=O)[O-])c3)o2)cc1>>COc1ccc(-c2nnc(-c3ccc(N)c(N)c3)o2)cc1,O=[Pt]=O,C1CCOC1,CCO,,,val
US20130150356A1,Cc1ccc(C(=O)N2CCNCC2)cc1F.Clc1cc(Cl)ncn1>>Cc1ccc(C(=O)N2CCN(c3cc(Cl)ncn3)CC2)cc1F,,C1COCCO1,,CCN(CC)CC,Cl,val
US20080096877A1,CCN=C=NCCCN(C)C.Cc1ccc(N(C)S(=O)(=O)c2cccs2)c2[nH]c(C3=NCC(CC(=O)O)S3)cc12>>Cc1ccc(N(C)S(=O)(=O)c2cccs2)c2[nH]c(C3=NCC(CC(N)=O)S3)cc12,,CCOC(C)=O,,CN(C)C=O,Cl,val
US06117870,CCCC[C@H](N)C(O)C(=O)NC(C)(C)C.O=C(NC1(C(=O)O)CCCCC1)N1CCOCC1>>CCCC[C@H](NC(=O)C1(NC(=O)N2CCOCC2)CCCCC1)C(O)C(=O)NC(C)(C)C,,CCOC(C)=O,ClCCl,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US04230703,CC(=O)Cl.O=C1c2ccccc2CN(Cc2ccccc2)c2ccccc21>>CC(=O)c1ccc2c(c1)C(=O)c1ccccc1CN2Cc1ccccc1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080153871A1,CC(C)c1cccc(C(=O)O)c1O.[Li]C>>CC(=O)c1cccc(C(C)C)c1O,,C1CCOC1,,,,val
US20060247320A1,CC(C)(C)OC(=O)N[C@H](CN=[N+]=[N-])c1cccc(Br)c1>>[N-]=[N+]=NC[C@@H](N)c1cccc(Br)c1,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20120184735A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1.Cl>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1.Cl,,O,,,,val
US20090209607A1,C=Cc1cnn(C)c1-c1cc(C(=O)OC)sc1CC>>CCc1cnn(C)c1-c1cc(C(=O)OC)sc1CC,[Pd],CO,,,,val
US06211234B1,ClCc1cccnc1.O=[N+]([O-])c1ccc(O)cc1F>>O=[N+]([O-])c1ccc(OCc2cccnc2)cc1F,,CN(C)C=O,,Cl,[H-].[Na+],val
US20130029961A1,CNCCO.O=[N+]([O-])c1ccc(Cl)nc1>>CN(CCO)c1ccc([N+](=O)[O-])cn1,,O,,,,val
US20050075331A1,CC(C)CCn1ccc(O)cc1=O.COS(=O)(=O)OC(SC)(SC)SC>>CSC(SC)=C1C(=O)C=CN(CCC(C)C)C1=O,,C1COCCO1,,c1ccncc1,,val
US20100168418A1,Cc1cc2ccccc2n(CCN2CCC(N(Cc3ccc4c(c3)OCCO4)C(=O)OC(C)(C)C)CC2)c1=O>>Cc1cc2ccccc2n(CCN2CCC(NCc3ccc4c(c3)OCCO4)CC2)c1=O,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US05639782,C1COCCN1.CCCOc1c(OC)cc([C@@H]2SC[C@@H](c3cc(OC)c(OC)c(OC)c3)S2)cc1S(=O)(=O)CCO>>CCCOc1c(OC)cc([C@@H]2SC[C@@H](c3cc(OC)c(OC)c(OC)c3)S2)cc1S(=O)(=O)CCN1CCOCC1,,CCO,,,,val
US20150274696A1,Cc1nc2cc(F)c([N+](=O)[O-])cc2s1>>Cc1nc2cc(F)c(N)cc2s1,[Fe],CCO,CCO,Cl,,val
US20050080111A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)Cc1cc(Br)cc(C(C)C)c1>>COC(=O)Cc1cc(B2OC(C)(C)C(C)(C)O2)cc(C(C)C)c1,,CS(C)=O,,ClCCl,CC(=O)[O-].[K+],val
US20060069110A1,CC(=O)Cc1ccccc1.[Li]C>>CC(C)(O)Cc1ccccc1,Cl[Ti](Cl)(Cl)Cl,CCOCC,,,,val
US20150094297A1,CCOC(=O)c1csc(C2(c3cccnc3)CCC2)n1>>OCc1csc(C2(c3cccnc3)CCC2)n1,,C1CCOC1,,CO,[BH4-].[Li+],val
US20110118245A1,COC(=O)c1ccc(OCCCl)c(OC)c1.O=[N+]([O-])O>>COC(=O)c1cc(OC)c(OCCCl)cc1[N+](=O)[O-],,CC(=O)O,,CC(=O)OC(C)=O,,val
US20110300116A1,BrBr.COc1ccc2c(c1)C(c1ccc([N+](=O)[O-])cc1)CN(C)CC2>>COc1cc2c(cc1Br)CCN(C)CC2c1ccc([N+](=O)[O-])cc1,,C1CCOC1,ClC(Cl)Cl,,,val
US20130072467A1,O=C1CCC(C(=O)[O-])CCN1>>OCC1CCCNCC1,,C1CCOC1,O,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20120101136A1,Cc1cc(OCOCC[Si](C)(C)C)ccc1C#N.NO>>Cc1cc(OCOCC[Si](C)(C)C)ccc1C(=N)NO,,CCO,,Cl,O=C([O-])O.[Na+],val
US20160072082A1,Cc1ccc2c3c1c1ccccc1c1ncc(n13)CC2(C)C.O=C1CCC(=O)N1Br>>Cc1ccc2c3c1c1ccccc1c1nc(Br)c(n13)CC2(C)C,,ClCCl,O,,,val
US20040006099A1,CCOC(=O)CN1CCC(COc2ccc3c(c2)CN(C(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)CC3)CC1>>CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)N1CCc2ccc(OCC3CCN(CCO)CC3)cc2C1,,C1CCOC1,CO,O,[BH4-].[Li+],val
US20050119295A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.NCc1ccccc1.O=[N+]([O-])C=Cc1ccc(C(F)(F)F)cc1>>FC(F)(F)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1,,CC#N,,,,val
US04812164,CC(C)Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(F)cc1Br.O=P(Cl)(Cl)Cl>>CC(C)Oc1cc(-n2c(Cl)nc(C(F)(F)F)cc2=O)c(F)cc1Br,,c1ccncc1,,,,val
US20100222600A1,CC(C)(C)OC(=O)NCC1CCN1.O=S(=O)(Cl)c1ccccc1-c1ccccc1>>CC(C)(C)OC(=O)NCC1CCN1S(=O)(=O)c1ccccc1-c1ccccc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US05262390,COc1ccc(-n2nc3c(c2Cl)CCCC3)c(F)c1>>Oc1ccc(-n2nc3c(c2Cl)CCCC3)c(F)c1,,ClCCl,,BrB(Br)Br,,val
US20080161366A1,O=[N+]([O-])c1ccccc1Nc1ccc2ccccc2c1>>Nc1ccccc1Nc1ccc2ccccc2c1,[Pd],CCOC(C)=O,,,,val
US20100048556A1,CCOC(=O)CCc1nccn1-c1ccc(C)cc1N.O=C(n1ccnc1)n1ccnc1>>Cc1ccc2c(c1)[nH]c(=O)c1cnc(CCC(=O)O)n12,,Clc1ccccc1Cl,,,,val
US20150133428A1,Fc1ccc(-c2cc3n(n2)CCN(Cc2ccccc2)C3)cc1>>Fc1ccc(-c2cc3n(n2)CCNC3)cc1,[Pd],CO,,,,val
US20060089393A1,CC(=N)NNC(=O)c1ccc(-c2cc(C(=O)NC3CC3)ccc2C)cc1>>Cc1nnc(-c2ccc(-c3cc(C(=O)NC4CC4)ccc3C)cc2)[nH]1,,Cc1ccccc1C,,,,val
US20100004230A1,Cl.NC1CCN(CC2Cc3c(F)ccc4ccc(=O)n2c34)CC1.O=Cc1cc2c(cn1)OCCO2>>Cl.O=c1ccc2ccc(F)c3c2n1C(CN1CCC(NCc2cc4c(cn2)OCCO4)CC1)C3,,ClCCl,,CCN(CC)CC,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100009991A1,CCOC(=O)COc1cccc(CCCn2cc(-c3ccccc3Br)ccc2=O)c1.COc1ccccc1B(O)O>>CCOC(=O)COc1cccc(CCCn2cc(-c3ccccc3-c3ccccc3OC)ccc2=O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20110319394A1,CC(C)n1c(=O)n(-c2ccc3c(c2)CCN3)c2ncccc21.Clc1nc2cccnc2[nH]1>>CC(C)n1c(=O)n(-c2ccc3c(c2)CCN3c2nc3cccnc3[nH]2)c2ncccc21,,CN1CCCC1=O,,O=C([O-])O.[Na+],,val
US06911516B1,Brc1cccc2cccnc12.O=C1CCc2ccccc21>>C1=CC(c2cccc3cccnc23)c2ccccc21,,C1CCOC1,,Cl,[Li]CCCC,val
US20090221555A1,CCN1CC(=O)Nc2cc(N)c(OC)cc2C1.CN(C)S(=O)(=O)c1ccccc1Nc1nc(Cl)ncc1Cl>>CCN1CC(=O)Nc2cc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)N(C)C)n3)c(OC)cc2C1,,CO,ClCCl,,,val
US05514717,CC(C)(C)OP(=O)(CC(F)=C(F)F)OC(C)(C)C>>O=P(O)(O)CC(F)=C(F)F,,CO,,Cl,,val
US20020007059A1,COC(=O)COC(C)(C)C(C)=O>>CC1(C)OCC(=O)CC1=O,,CCOCC,,CC(C)(C)[O-].[K+],,val
US20130303533A1,Cn1cc(C#N)c(N)n1.O=S(=O)(O)O>>Cn1cc(C(N)=O)c(N)n1,,O,,[NH4+].[OH-],,val
US04180672,COC(=O)CCCCCSC1=CCCC1=O>>O=C(O)CCCCCSC1=CCCC1=O,,CO,O,[Na+].[OH-],,val
US20050245743A1,COc1ccccc1CCCCC(=O)Nc1cc(C2CCN(C(=O)OC(C)(C)C)CC2)c(F)cc1F>>COc1ccccc1CCCCC(=O)Nc1cc(C2CCNCC2)c(F)cc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160083366A1,CI.N#Cc1ccc(F)c(=O)[nH]1>>Cn1c(C#N)ccc(F)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040067955A1,COC(=O)Cn1nc(-c2cc(Cl)c(N)nc2-c2ccccc2)ccc1=O>>Nc1nc(-c2ccccc2)c(-c2ccc(=O)n(CC(=O)O)n2)cc1Cl,,CO,,O,[Na+].[OH-],val
US20080032968A1,CI.O=Cc1c(O)c(F)cc2c1ccn2S(=O)(=O)c1ccccc1>>COc1c(F)cc2c(ccn2S(=O)(=O)c2ccccc2)c1C=O,,CC(C)=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20140066425A1,CC(C)(C)OC(=O)n1ccnc1CCCc1ccc(NC(=O)OCc2ccccc2)cc1>>CC(C)(C)OC(=O)n1ccnc1CCCc1ccc(N)cc1,[Pd],CCOC(C)=O,,,,val
US20040225111A1,CC(C)(C)OC(=O)[C@H](Cc1ccc(OCCCC(=O)NC2=NCCCN2)cc1)Nc1nc2ccc(Br)cc2s1>>O=C(CCCOc1ccc(C[C@H](Nc2nc3ccc(Br)cc3s2)C(=O)O)cc1)NC1=NCCCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130317026A1,CS(=O)(=O)Cl.Cc1cc(C)c(CNC(=O)c2cc(C3=CCN(C4CCNCC4)CC3)nc3c2cnn3C(C)C)c(=O)[nH]1>>Cc1cc(C)c(CNC(=O)c2cc(C3=CCN(C4CCN(S(C)(=O)=O)CC4)CC3)nc3c2cnn3C(C)C)c(=O)[nH]1,,ClCCl,,CCN(CC)CC,,val
US20150094306A1,Cc1cc(CO)cnc1OCC(F)(F)F.O=S(Cl)Cl>>Cc1cc(CCl)cnc1OCC(F)(F)F,,ClCCl,,,,val
US07071201B2,CC(=O)Nc1ccc(CCN2CCC(N3CCc4ccccc43)CC2)cc1>>CCNc1ccc(CCN2CCC(N3CCc4ccccc43)CC2)cc1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20140221333A1,O=C(NCc1nccnc1Cl)C1CCC(C(F)(F)F)N(C(=O)OCc2ccccc2)C1>>O=C(OCc1ccccc1)N1CC(c2ncc3c(Cl)nccn23)CCC1C(F)(F)F,CN(C)C=O,CC#N,,O=P(Cl)(Cl)Cl,,val
US06369086B1,CCOC(=O)CC(=O)OCC.O=[N+]([O-])c1cnccc1Cl>>CCOC(=O)C(C(=O)OCC)c1ccncc1[N+](=O)[O-],,Cc1ccccc1,,[H-].[Na+],,val
US20070072893A1,CCCc1nc2cnc3ccccc3c2n1CCCCCC(=O)OCC>>CCCc1nc2cnc3ccccc3c2n1CCCCCC(=O)O,,CCO,O,[Na+].[OH-],,val
US20010034051A1,CCN(C(C)C)C(C)C.NCCNc1ccc([N+](=O)[O-])c(N)n1.O=[N+]([O-])c1ncc(Br)nc1-c1ccc(Cl)cc1Cl>>Nc1cc(NCCNc2cnc([N+](=O)[O-])c(-c3ccc(Cl)cc3Cl)n2)ccc1[N+](=O)[O-],,CN(C)C=O,,,,val
US20150152069A1,CC(=O)N1CCN(c2ccc([N+](=O)[O-])c(Cl)c2)CC1>>CC(=O)N1CCN(c2ccc(N)c(Cl)c2)CC1,,CCO,,,,val
US20090042918A1,Nc1nc(NCc2ccccc2)ncc1-c1nnn[nH]1.O=C(Cl)c1cccs1>>O=C(Nc1nc(NCc2ccccc2)ncc1-c1nnn[nH]1)c1cccs1,,ClCCCl,,CCN(C(C)C)C(C)C,,val
US20140200231A1,C#CCCOC1CCCCO1.[N-]=[N+]=NCc1ccccc1>>OCCc1cnnn1Cc1ccccc1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20110136800A1,CC[C@@]12CCCN[C@H]1CCc1ccccc12.O=C(O)c1ccc2[nH]cnc2c1>>CC[C@@]12CCCN(C(=O)c3ccc4[nH]cnc4c3)[C@H]1CCc1ccccc12,,CO,ClCCl,,,val
US04694008,O=c1[nH]c(CCCOc2cccc(CN3CCCCC3)c2)ncc1OCc1ccccc1>>O=c1[nH]c(CCCOc2cccc(CN3CCCCC3)c2)ncc1O,,Cl,,,,val
US20060252807A1,COC(=O)c1sc(C)nc1-c1ccc(F)cc1>>Cc1nc(-c2ccc(F)cc2)c(C(=O)O)s1,,CCO,,O,[K+].[OH-],val
US20070249688A1,COC(=O)c1ccc(C(O)C(C)C)cc1.Cc1cc(O)cc(C)c1Br>>COC(=O)c1ccc(C(Oc2cc(C)c(Br)c(C)c2)C(C)C)cc1,,Cc1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20110039842A1,CCOC(=O)c1ncoc1Cc1ccc(Cl)c(F)c1.Cl>>Cl.NCC(=O)Cc1ccc(Cl)c(F)c1,,Cl,,,,val
US20090118279A1,CC(C)CN1CCC2(CCNC2)CC1.CCOC(OCC)c1ccc(C=O)cc1>>CCOC(OCC)c1ccc(CN2CCC3(CCN(CC(C)C)CC3)C2)cc1,,CC(=O)O,CN(C)C=O,[Na+].[OH-],,val
US04242507,CS(=O)(=O)Cl.O=c1c2ccccc2nnn1O>>CS(=O)(=O)On1nnc2ccccc2c1=O,,c1ccccc1,,CCN(CC)CC,,val
US04946787,CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC.CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)CCCCCCCC=CCCCCCCCC>>CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC.CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)CCCCCCCC=CCCCCCCCC,,ClC(Cl)Cl,,,,val
US05250517,C=C[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cn(C(=O)OC(C)(C)C)cn1)NC(=O)OC(C)(C)C)C(C)C>>C=C[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C,,C1COCCO1,Cl,O=C([O-])[O-].[Na+].[Na+],,val
US20150329523A1,COCCOCCOCCBr.O=[N+]([O-])c1cc(O)cc(C(F)(F)F)c1>>COCCOCCOCCOc1cc([N+](=O)[O-])cc(C(F)(F)F)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20070054903A1,Brc1cccc2cnccc12.COC(=O)c1cccc2cc(B3OC(C)(C)C(C)(C)O3)ccc12>>COC(=O)c1cccc2cc(-c3cccc4cnccc34)ccc12,,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US06211234B1,CCC(CC)(C(=O)O)P(=O)(O)O.O=Cc1ccc(OCc2ccccc2)cc1OCc1ccccc1>>O=C(O)/C=C/c1ccc(OCc2ccccc2)cc1OCc1ccccc1,,C1CCOC1,,O,[Li]CCCC,val
US20090054508A1,COC1CCC(OC)O1.Nc1ccccc1/C=C/c1n[nH]c2ccccc12>>C(=C/c1n[nH]c2ccccc12)\c1ccccc1-n1cccc1,,CC(=O)O,,O,,val
US20020016368A1,CCI.O=C(O)Cc1cccc(Br)c1>>CCOC(=O)Cc1cccc(Br)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120122900A1,Cc1nc(O)ccc1Br.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>Cc1c(Br)ccc(=O)n1CC(F)(F)F,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060004052A1,CN(C(=O)OC(C)(C)C)[C@H](Cc1ccc(O)cc1)C(=O)Nc1cc2c3c(c(-c4ccccc4)[nH]c3c1)C=NNC2=O.Cl>>CN[C@H](Cc1ccc(O)cc1)C(=O)Nc1cc2c3c(c(-c4ccccc4)[nH]c3c1)C=NNC2=O.Cl,,C1COCCO1,,CCN(CC)CC,,val
US20150299121A1,CCOC(=O)C1(C(=O)OCC)CC2(CCC2)C1>>O=C(O)C1(C(=O)O)CC2(CCC2)C1,,CCO,,[K+].[OH-],,val
US20050239827A1,O=C(Nc1ccc(NC(=O)c2cccnc2OCc2ccccc2)c(OCc2ccccc2)c1)OCC1c2ccccc2-c2ccccc21>>Nc1ccc(NC(=O)c2cccnc2OCc2ccccc2)c(OCc2ccccc2)c1,,C1CCOC1,CN(C)C=O,C1CCNCC1,,val
US05326498,CCCCCC(=O)O.CCCCCc1ccc(-c2ncc(-c3ccc(O)cc3)cn2)cc1>>CCCCCC(=O)Oc1ccc(-c2cnc(-c3ccc(CCCCC)cc3)nc2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04977146,CC(=O)CCl.CCCOc1c(O)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO>>CCCOc1c(OCC(C)=O)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO,,CN(C)C=O,O,CCOCC,O=C([O-])[O-].[K+].[K+],val
US06852725B1,CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)c1nc(-c2ccccc2)cn1CC(=O)c1ccccc1>>c1cnc2c(n1)NCN2,,ClCCl,O=C(O)C(F)(F)F,,,val
US04716157,[N-]=[N+]=N[C@H](CO)[C@H](CCO)N=[N+]=[N-]>>N[C@H](CO)[C@@H](N)CCO,O=[Pt]=O,CCO,,,,val
US06579933B1,C=CCN.O=S(=O)(O)O>>C=CCN.O=S(=O)(O)O,,O,,,,val
US06150373,Cc1cccc(Cl)c1N1Cc2cnc(Nc3ccccc3)nc2N(c2cccc(CCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)c2)C1=O>>Cc1cccc(Cl)c1N1Cc2cnc(Nc3ccccc3)nc2N(c2cccc(CCO)c2)C1=O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040138211A1,COC(=O)C(Cc1ccc(OCCOc2ccc3ccccc3c2)cc1)C(=O)O.N>>COC(=O)C(Cc1ccc(OCCOc2ccc3ccccc3c2)cc1)C(N)=O,,CCOC(C)=O,c1ccccc1,O=S(Cl)Cl,,val
US20060293299A1,CCOCC.COC(=O)C(c1cc(F)cc(F)c1)C1CN(C(c2ccc(Cl)cc2)c2cccc(Cl)c2)C1.[Li]C>>CC(C)(O)C(c1cc(F)cc(F)c1)C1CN(C(c2ccc(Cl)cc2)c2cccc(Cl)c2)C1,,C1CCOC1,,,,val
US20080300242A1,C#CCO.COc1cc(Br)ccc1[N+](=O)[O-]>>COc1cc(C#CCO)ccc1[N+](=O)[O-],CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C,CC#N,CCOCC,C1CN2CCN1CC2,,val
US20140228386A1,Cc1c(F)sc2ccc(Br)cc12.O=C1NCCN1c1cnccc1C1CC1>>Cc1c(F)sc2ccc(N3CCN(c4cnccc4C4CC4)C3=O)cc12,I[Cu]I,C1COCCO1,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20020065401A1,CC(C)(C)C1CCC(=O)C(C(C)(C)C)C1>>CC(C)(C)C1CCC(O)C(C(C)(C)C)C1,,CCOCC,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20090275611A1,O=S(=O)(c1ccccc1)c1ccc(CNC[C@@H](O)c2ccccc2)cc1>>O=S(=O)(c1ccccc1)c1ccc(CNC[C@H](O)c2ccccc2)cc1,,CCOCC,,,,val
US20090181963A1,CC(C)(C)OC(=O)N1CCC(n2nnc3c(N4CCOCC4)nc(Cl)nc32)CC1.CC1(C)OB(c2ccnc(N)n2)OC1(C)C>>CC(C)(C)OC(=O)N1CCC(n2nnc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc32)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20070185079A1,COc1ccc2c(C)cc(N[C@H]3CC[C@H](N)C3)nc2c1.O=Cc1ccn(-c2ccc(C(F)(F)F)cc2)c1>>COc1ccc2c(C)cc(N[C@H]3CC[C@H](NCc4ccn(-c5ccc(C(F)(F)F)cc5)c4)C3)nc2c1,,ClCCl,,,,val
US20130217680A1,BrBr.COc1ccc(C#N)c(F)c1>>COc1cc(F)c(C#N)cc1Br,,ClC(Cl)Cl,,ClCCl,,val
US06479670B1,COCC1(C)CCCSc2cc(C#Cc3ccc(C(=O)OC)cc3)ccc21>>COCC1(C)CCCSc2cc(C#Cc3ccc(C(=O)O)cc3)ccc21,,C1CCOC1,CCO,[Na+].[OH-],,val
US20040038961A1,CC(C)(C)OC(=O)c1ccc(Cn2ccc3cnc(C#CCn4ccnn4)cc3c2=O)cc1>>O=C(O)c1ccc(Cn2ccc3cnc(C#CCn4ccnn4)cc3c2=O)cc1,,O=C(O)C(F)(F)F,,,,val
US05801202,CCCCC(C)CCCCCCCCCCCOCC1CO1.OCCNCCO>>CCCCC(C)CCCCCCCCCCCOCC(O)CN(CCO)CCO,,CCO,,,,val
US20030087920A1,COc1cc(OC)nc(S(C)(=O)=O)n1.Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)C)cn3)nc(-c3ccncc3)nc2OCC#CCO)cc1>>COc1cc(OC)nc(OCC#CCOc2nc(-c3ccncc3)nc(NS(=O)(=O)c3ccc(C(C)C)cn3)c2-c2ccc(C)cc2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070032494A1,C=O.CNC.Cc1cccc(C)c1O>>Cc1cc(CN(C)C)cc(C)c1O,,CCO,O,Cl,,val
US20100249099A1,CN(C)CCCOc1cccc2c1nc(C(F)F)n2-c1nc(N2CCNCC2)nc(N2CCOCC2)n1.CS(=O)(=O)Cl>>CN(C)CCCOc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(S(C)(=O)=O)CC2)n1,,ClCCl,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2cc(C#N)c(O[C@H]3CCC[C@@H]3c3ccnn3C)cc2F)c(OC)c1>>Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(S(=O)(=O)Nc2ccncn2)cc1C#N,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20090062251A1,CC(C)(C)OC(=O)[C@H]1CCCN1.CCS(=O)(=O)n1c2c(c3cc(C(=O)O)ccc31)CC(C1CCOCC1)CC2.CN(C)C=O>>CCS(=O)(=O)n1c2c(c3cc(C(=O)N(C)CC(=O)NC4CC4)ccc31)CC(C1CCOCC1)CC2,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040006067A1,CC(C)(C)OC(=O)N1CCC(c2ccccc2C(F)(F)F)CC1.Cl>>Cl.FC(F)(F)c1ccccc1C1CCNCC1,,CCOC(C)=O,,,,val
US20130072467A1,CN1CCCC(NC2=NC(=O)SC2)C1=O.O=CC1CCN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)CC1>>CN1CCCC(NC2=NC(=O)S/C2=C\C2CCN(Cc3ccc(C(F)(F)F)cc3C(F)(F)F)CC2)C1=O,,CC(C)O,,C1CC[NH2+]CC1.CC(=O)[O-],,val
US05236952,Nc1nncs1.O=C(CBr)c1cc(O)c(O)c([N+](=O)[O-])c1>>O=[N+]([O-])c1cc(-c2cn3ncsc3n2)cc(O)c1O,,CCCCO,,,,val
US20020049194A1,CCOC(=O)CC1CCCN(C(=O)c2ccc(C3CCCCC3)cc2)c2ccc(Cl)cc21>>O=C(O)CC1CCCN(C(=O)c2ccc(C3CCCCC3)cc2)c2ccc(Cl)cc21,,CCO,,Cl,[Na+].[OH-],val
US20090298896A1,CCCCCCc1nc(-c2ccc(C)cc2)sc1CO.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC(=O)[O-].CCCCCCc1nc(-c2ccc(C)cc2)sc1C=O,,ClCCl,,CCOCC,,val
US20130150414A1,Nc1ccccn1.O=C(O)C(F)(F)C(F)(F)F>>O=C(N=c1cccc[nH]1)C(F)(F)C(F)(F)F,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20130035446A1,COC(=O)/C=C/c1ccc(OC(F)(F)c2ccc(OCCCC(F)(F)F)cc2)cc1>>O=C(O)/C=C/c1ccc(OC(F)(F)c2ccc(OCCCC(F)(F)F)cc2)cc1,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20090131413A1,Cc1cc([N+](=O)[O-])ccc1F.OC1CCNCC1>>Cc1cc([N+](=O)[O-])ccc1N1CCC(O)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05194442,O=C(Cl)CCCOc1ccccc1>>O=C1CCCOc2ccccc21,,ClCCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20070054924A1,COC(=O)c1nnn(Cc2ccc(OC)cc2)c1N(C)S(C)(=O)=O>>COC(=O)c1nn[nH]c1N(C)S(C)(=O)=O,,O=C(O)C(F)(F)F,,,,val
US20160102083A1,CCC(c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1>>CCC(c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)[C@@H]1CC[C@@H](N)CC1,,CO,,C1COCCO1,Cl,val
US20050096380A1,CCOC(=O)/C=C(C)/C=C/C(F)=C(/CC)c1cc2c(c(Cl)c1OC)OC(C)(C)C=C2C(C)C>>CC/C(=C(F)/C=C/C(C)=C/C(=O)O)c1cc2c(c(Cl)c1OC)OC(C)(C)C=C2C(C)C,,C1CCOC1,CCO,[Na+].[OH-],,val
US04054668,C=CCBr.CCOC(=O)CNC>>C=CCN(C)CC(=O)OCC,,c1ccccc1,,CCN(CC)CC,,val
US20100331293A1,COc1ccc(B(O)O)cn1.Cc1c(Cl)nc2cc(F)cc(F)c2c1Cl>>COc1ccc(-c2nc3cc(F)cc(F)c3c(Cl)c2C)cn1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20080207590A1,COC(=O)c1ccc(O)cc1.O=C(CBr)N1C=C2CC=CC=C2Oc2ccccc21>>COC(=O)c1ccc(OCC(=O)N2C=C3CC=CC=C3Oc3ccccc32)cc1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05866567,Nc1ccc(CN2C(=O)[C@H]3CCC[C@H]3N(C(=O)CN3C(=O)c4ccccc4C3=O)c3ccccc32)cc1.O=C=NCc1ccccc1>>O=C(NCc1ccccc1)Nc1ccc(CN2C(=O)[C@H]3CCC[C@H]3N(C(=O)CN3C(=O)c4ccccc4C3=O)c3ccccc32)cc1,,ClCCl,,,,val
US05284863,C=C(Cl)C#N.FC(F)(F)SC(Cl)=NCc1ccc(Cl)cc1>>N#Cc1cc(SC(F)(F)F)[nH]c1-c1ccc(Cl)cc1,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,,val
US20100075948A1,CC(C)(C)CC1NC(C(=O)OC(C)(C)C)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1.O=C(O)C(F)(F)F>>CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20050113397A1,C[C@H]1CNCCN1.Cc1c(-c2ccccc2)c(Cl)n2c(nc3ccccc32)c1C#N>>Cc1c(-c2ccccc2)c(N2CCN[C@@H](C)C2)n2c(nc3ccccc32)c1C#N,,CS(C)=O,,CCN(CC)CC,O,val
US06350749B1,N.O=C(O)c1coc2c1C(=O)CC(c1ccccc1)C2>>NC(=O)c1coc2c1C(=O)CC(c1ccccc1)C2,,ClCCl,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20030060453A1,O=[N+]([O-])c1ccc2nsnc2c1>>Nc1ccc2nsnc2c1,[Zn],C1CCOC1,,O,,val
US20020120144A1,COC(OC)c1cc(C)c(C=O)nc1C.O=C1CSC(=O)N1>>CC1=CC(C=O)=C(C)NC1=C1SC(=O)NC1=O,,CCO,O,C1CCNCC1,Cl,val
US06924374B2,OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(Cc2ccccc2)CC1>>FC(F)(F)c1cc(C2=CCN(Cc3ccccc3)CC2)ccc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040127574A1,COc1ccc(CC(N)C(O)c2ccc(F)cc2)cc1.O=C(Cl)c1cccc2ccccc12>>COc1ccc(CC(NC(=O)c2cccc3ccccc23)C(O)c2ccc(F)cc2)cc1,,CCOC(C)=O,O,O=C([O-])O.[Na+],,val
US20070244092A1,CC(C)(C)c1nc2cc(S(=O)(=O)Cl)ccc2n1CC1CCOCC1.c1cc[nH]c1>>CC(C)(C)c1nc2cc(S(=O)(=O)n3cccc3)ccc2n1CC1CCOCC1,,C1CCOC1,,[H-].[Na+],,val
US20070179178A1,Cc1onc(-c2ccccc2)c1C(=O)CBr.Nc1ccccn1>>Cc1onc(-c2ccccc2)c1-c1cn2ccccc2n1,,CCO,,O=C([O-])O.[Na+],,val
US20060009497A1,COC(=O)C1=C(c2ccc(OCCOc3cc(C)c(C)cc3Cl)cc2)CCN(C(=O)OC(C)(C)C)C1>>Cc1cc(Cl)c(OCCOc2ccc(C3=C(C(=O)O)CN(C(=O)OC(C)(C)C)CC3)cc2)cc1C,,CCO,,[Na+].[OH-],,val
US20140187588A1,C[C@@H]1OC(=O)[C@@H](N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)CCC[C@H](Oc2ccccc2)[C@H]1Oc1ccccc1.Cl>>C[C@@H]1OC(=O)[C@@H]([NH3+])CCC[C@H](Oc2ccccc2)[C@H]1Oc1ccccc1.[Cl-],,ClC(Cl)Cl,,,,val
US20080114007A1,CS(=O)(=O)Cl.NCCc1ccc([N+](=O)[O-])cc1>>CS(=O)(=O)NCCc1ccc(N)cc1,,ClCCl,,CCN(CC)CC,,val
US20080261941A1,COc1ccc(NC(=O)Oc2ccccc2)cn1.FC(=C1CCNCC1)c1cccc(Oc2ccc(C(F)(F)F)cn2)c1>>COc1ccc(NC(=O)N2CCC(=C(F)c3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cn1,CCN(CC)CC,CS(C)=O,O,,,val
US05739345,O=C1SC(Cc2ccc(OCCc3c[nH]c4ccccc34)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1>>O=C1NC(=O)C(Cc2ccc(OCCc3c[nH]c4ccccc34)cc2)S1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060004108A1,CC1(C)C2CC[C@@]1(C)C(=O)CC2=O.O=C=Nc1ccc(F)c(Cl)c1>>CC1(C)C2CC[C@@]1(C)C(=O)C(C(=O)Nc1ccc(F)c(Cl)c1)C2=O,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,Cl,val
US20020193407A1,CCSc1ccc(CCl)cc1.CCc1n[nH]cc1C1CCN(C(=O)OC(C)(C)C)CC1>>CCc1nn(Cc2ccc(SC)cc2)cc1C1CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20050020605A1,CCO/N=C(\c1ccc(Br)cc1)C1CCN(C2(C)CCNCC2)CC1.Cc1cc(C(=O)O)c2ccccc2n1>>CCO/N=C(\c1ccc(Br)cc1)C1CCN(C2(C)CCN(C(=O)c3cc(C)nc4ccccc34)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090197871A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(C#N)c(-c3cccc(C=O)c3)c2)c1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(C#N)c(-c3cccc(CN4C[C@@H]5C[C@H]4CN5)c3)c2)c1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20050113340A1,CI.COc1cc(Cn2cnc3c(Cl)nc(NC(C)=O)nc32)c(Br)c(OC)c1OC>>COc1cc(Cn2cnc3c(Cl)nc(N(C)C(C)=O)nc32)c(Br)c(OC)c1OC,,CN(C)C=O,,[H-].[Na+],,val
US06265349B1,Cn1c(C(F)(F)F)ccc(-c2c(F)cc(Cl)c3oc(C(Br)Br)cc23)c1=O.O>>Cn1c(C(F)(F)F)ccc(-c2c(F)cc(Cl)c3oc(C=O)cc23)c1=O,,O,,O=S(=O)(O)O,,val
US20050153959A1,CCc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nnn[nH]2)cc2c(C)n[nH]c12.CI>>CCc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nnnn2C)cc2c(C)n[nH]c12,,CS(C)=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US05686424,NC(=O)C[C@H](N)C(=O)NCc1ccccc1.O=C(O)[C@@H]1CCCN1CC(=O)C12CC3CC(CC(C3)C1)C2>>NC(=O)C[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)C12CC3CC(CC(C3)C1)C2,,ClCCl,,CCN(CC)CC,,val
US20130165436A1,CC(C)(C)OC(=O)N1CC[C@@H](OS(C)(=O)=O)C1.COc1ncc(N2CCOc3cnc(O)cc32)cc1C>>COc1ncc(N2CCOc3cnc(O[C@H]4CCN(C(=O)OC(C)(C)C)C4)cc32)cc1C,,CN(C)C=O,,[H-].[Na+],,val
US20130267499A1,C=CCN(C)c1nn(Cc2ccc(OC)cc2)cc1C(=O)N(C)OC.C=C[Mg]Br>>C=CCN(C)c1nn(Cc2ccc(OC)cc2)cc1C(=O)C=C,,C1CCOC1,,,,val
US20100204240A1,Cc1ncccc1Oc1cc(Br)cnc1Nc1nc([C@H]2COC3(CCCCC3)O2)ns1>>Cc1ncccc1Oc1cc(Br)cnc1Nc1nc([C@H](O)CO)ns1,Cl,CO,,,,val
US04179505,CCNc1ccc(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1N.CCOC(C)=N>>CCn1c(C)nc2cc(CN3CCN(C(c4ccccc4)c4ccccc4)CC3)ccc21,,CC(=O)O,,Cl,,val
US20080280961A1,CCOC(=O)CO.Cc1ccc2nc(Cl)oc2c1>>CCOC(=O)COc1nc2ccc(C)cc2o1,,C1CCOC1,,[H-].[Na+],,val
US20130245035A1,CCOC(=O)c1cc(C2CC2)c2c(C)c(Cl)ccn2c1=O.Cc1ccc(B(O)O)cc1>>CCOC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(C)cc3)ccn2c1=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20020025958A1,COc1ccc(CC(C)=O)cc1NC(C)=O>>COc1ccc(CC(C)O)cc1NC(C)=O,,CO,,[BH4-].[Na+],,val
US20140249126A1,COc1cc2c(c(N)c1OC)c(=O)c(C(=O)O)cn2C1CC1.Cl>>COc1cc2c(c(Cl)c1O)c(=O)c(C(=O)O)cn2C1CC1,,O,,O=N[O-].[Na+],,val
US20110034491A1,Nc1nc(O)ncc1F.S=C(Cl)Oc1ccccc1>>Nc1nc(=O)n(C(=S)Oc2ccccc2)cc1F,,ClCCl,,CC#N,,val
US20120202815A1,CC(=O)NCc1cc(-c2cc[nH]n2)ccc1Cl.Ic1ccc2c(c1)CCCO2>>CC(=O)NCc1cc(-c2ccn(-c3ccc4c(c3)CCCO4)n2)ccc1Cl,[Cu]I,C1COCCO1,,CN[C@@H]1CCCC[C@H]1NC,O=C([O-])[O-].[K+].[K+],val
US04537886,CCOC(=O)c1cn(-c2ccc([N+](=O)[O-])cc2)[nH]c1=O>>O=C(O)c1cn(-c2ccc([N+](=O)[O-])cc2)[nH]c1=O,,[Na+],[OH-],,,val
US07041689B2,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.CC1(C)OB(c2ccc3c(c2)C[C@H]2CC[C@@H](C3)[C@]23CN(CC(F)(F)F)S(=O)(=O)N3)OC1(C)C.O=S1(=O)N[C@@]2(CN1CC(F)(F)F)[C@@H]1CC[C@H]2Cc2ccc(-c3ncc(Br)s3)cc2C1>>CC(C)(C)OC(=O)N1CC=C(c2cnc(-c3ccc4c(c3)C[C@H]3CC[C@@H](C4)[C@]34CN(CC(F)(F)F)S(=O)(=O)N4)s2)CC1,,CS(C)=O,,,,val
US20100261755A1,COC(=O)N1CC[C@H](c2cc(=O)[nH]o2)C[C@H]1Cc1ccccc1F>>O=c1cc([C@H]2CCN[C@H](Cc3ccccc3F)C2)o[nH]1,,Br,,,,val
US20110021537A1,CCOC(=O)N1CCN(C(=O)OCc2ccccc2)[C@H](C)C1>>CCOC(=O)N1CCN[C@H](C)C1,[Pd],CCOC(C)=O,,,,val
US20100137313A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)c1cc(Br)cnc1OC(C)c1ccncc1>>COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)cnc1OC(C)c1ccncc1,,C1COCCO1,,ClCCl,CC(=O)[O-].[K+],val
US20130172292A1,COc1ccc(-c2nn(C(C)C)c3cccnc23)cn1>>CC(C)n1nc(-c2ccc(O)nc2)c2ncccc21,,CO,,Cl,,val
US20100249101A1,CC(=O)OC(C)=O.CC(=O)c1ccc(S(N)(=O)=O)c(Cl)c1>>CC(=O)NS(=O)(=O)c1ccc(C(C)=O)cc1Cl,,CC#N,O,O=S(=O)(O)O,,val
US20130059830A1,Fc1ccc(-c2cc(C3CCCNC3)n(-c3ncccn3)n2)cc1.O=CCC(F)(F)F>>Fc1ccc(-c2cc(C3CCCN(CCC(F)(F)F)C3)n(-c3ncccn3)n2)cc1,,ClCCCl,,CC(=O)O,[BH3-]C#N.[Na+],val
US20040138251A1,COc1cc(Nc2c(C#N)cnc3cc(/C=C/C(=O)OC(C)(C)C)sc23)c(Cl)cc1Cl>>COc1cc(Nc2c(C#N)cnc3cc(/C=C/C(=O)O)sc23)c(Cl)cc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US06579883B1,CC(C)(C)[Si](C)(C)Cl.O=C1Nc2cc(CCCO)ccc2C2CCCC12>>CC(C)(C)[Si](C)(C)OCCCc1ccc2c(c1)NC(=O)C1CCCC21,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20070105904A1,C[N+](=O)[O-].O=Cc1cccc(OCC2CC2)c1>>O=[N+]([O-])/C=C/c1cccc(OCC2CC2)c1,,CC(=O)O,,C,O=C[O-].[NH4+],val
US20020048687A1,Brc1c2ccccc2c(-c2c3ccccc3c(Br)c3ccccc23)c2ccccc12.Cc1ccccc1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1>>CC(=Cc1cccc(Br)c1)c1ccccc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20100093788A1,Cl.FC(F)(F)c1ccccc1-c1cc(C(F)(F)F)c2[nH]c(C3=NOC4(CCCCC4)C3)nc2c1>>Cl.FC(F)(F)c1ccccc1-c1cc(C(F)(F)F)c2[nH]c(C3=NOC4(CCCCC4)C3)nc2c1,,CCOCC,,CO,,val
US20020165241A1,N#Cc1cccnc1.NCC1CCN(C(=O)OCc2ccccc2)CC1>>N#Cc1cccnc1NCC1CCN(C(=O)OCc2ccccc2)CC1,,CCOC(C)=O,,CCOCC,,val
US20020161240A1,CC(=O)c1cccc(OCC(=O)OC(C)(C)C)c1.O=Cc1cccnc1>>CC(C)(C)OC(=O)COc1cccc(C(=O)C=Cc2cccnc2)c1,,CCO,,C1CCNCC1,,val
US20050277652A1,CCOC(=O)c1cc(Oc2ccc(NC(=O)OCc3ccccc3)c(F)c2)ccn1>>O=C(Nc1ccc(Oc2ccnc(C(=O)O)c2)cc1F)OCc1ccccc1,,CCO,O,Cl,[Li+].[OH-],val
US20060188547A1,COC(=O)C(C)Cl.O=[N+]([O-])c1ccc(O)cc1>>COC(=O)C(C)Oc1ccc([N+](=O)[O-])cc1,,CC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20040157866A1,CCOC(=O)C=Cc1cc([N+](=O)[O-])ccc1Cl.NCCc1ccccn1>>CCOC(=O)C=Cc1cc([N+](=O)[O-])ccc1NCCc1ccccn1,,O,,CCN(CC)CC,CCOC(C)=O,val
US20140142307A1,BrCc1ccc2cc3ccccc3cc2c1.BrCc1cnc2ccccc2n1.Clc1nc[nH]c1Cl>>Clc1c(Cl)[n+](Cc2ccc3cc4ccccc4cc3c2)cn1Cc1cnc2ccccc2n1.[Br-],,CC#N,,[K+].[OH-],,val
US20100197673A1,O=S1(=O)CCNCC1.O=[N+]([O-])c1cc(CI)cc2cc(-c3ccccc3)[nH]c12>>O=[N+]([O-])c1cc(CN2CCS(=O)(=O)CC2)cc2cc(-c3ccccc3)[nH]c12,,C1CCOC1,O,,,val
US20030007927A1,CC(=O)O.N#CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1.O>>O=C(O)CCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1,,Cl,O,,,val
US05252590,Cc1[nH]cnc1C(F)(F)C(F)(F)F.FC(F)Oc1cnc(Cl)c(Cl)c1>>Cc1c(C(F)(F)C(F)(F)F)ncn1-c1ncc(OC(F)F)cc1Cl,,CN(C)C=O,,O,[H-].[Na+],val
US20140113877A1,COc1ccc(OC)c(-c2cc3c(s2)c(=O)n(C2CCN(C(=O)OC(C)(C)C)CC2)c(=O)n3Cc2ccc(OC)c(F)c2)c1.Cl>>COc1ccc(OC)c(-c2cc3c(s2)c(=O)n(C2CCNCC2)c(=O)n3Cc2ccc(OC)c(F)c2)c1.Cl,,C1COCCO1,ClCCl,,,val
US04904815,C=C(C)c1ccccc1.COC(=O)CCCC(C)(C)c1ccc(O)c(C)c1>>COC(=O)CCCC(C)(C)c1cc(C)c(O)c(C(C)(C)c2ccccc2)c1,,ClCCl,,[O-][Cl+3]([O-])([O-])O,,val
US20030013754A1,CC(=O)c1cccc(N)c1.CCOC(=O)C(CC(C)=O)C(=O)c1ccccc1>>CCOC(=O)c1cc(C)n(-c2cccc(C(C)=O)c2)c1-c1ccccc1,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120015975A1,CCCNc1ccc(C(F)(F)F)cc1[N+](=O)[O-]>>CCCNc1ccc(C(F)(F)F)cc1N,[Pd],CCOC(C)=O,,,,val
US05254561,C[Mg]Br.O=C1CCCCc2ccccc21>>CC1(O)CCCCc2ccccc21,,CCOCC,,,,val
US20020022638A1,NCCc1ccc(-n2c(CCC3CCCC3)nc3cccnc32)cc1.O=c1[nH]c2cccc(OC[C@@H]3CO3)c2[nH]1>>O=c1[nH]c2cccc(OCC(O)CNCCc3ccc(-n4c(CCC5CCCC5)nc5cccnc54)cc3)c2[nH]1,,CO,ClC(Cl)Cl,,,val
US20110319424A1,CC1(NCc2ccc(C(F)(F)F)nc2)CCNCC1.O=CCn1c(=O)ccc2ncc(F)cc21>>CC1(NCc2ccc(C(F)(F)F)nc2)CCN(CCn2c(=O)ccc3ncc(F)cc32)CC1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110021489A1,COCCOc1noc(C2CNCC(c3ccc(CC(F)(F)F)cc3)C2)n1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>COCCOc1noc(C2CC(c3ccc(CC(F)(F)F)cc3)CN(C(=O)Oc3ccc([N+](=O)[O-])cc3)C2)n1,,ClCCl,,CCN(CC)CC,,val
US04389416,COc1ccc(O)c(Cl)c1Cl.O=[N+]([O-])c1ccc(F)cc1>>COc1ccc(Oc2ccc([N+](=O)[O-])cc2)c(Cl)c1Cl,,CN(C)C=O,,[H-].[Na+],,val
US20130236468A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2.Cl>>CC(=O)N1C[C@@H]2C[C@H]1CN2.Cl,,ClCCl,,C1COCCO1,,val
US20130023523A1,CCOC(=O)c1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1C(=O)c1ccccc1.CNN>>CN1CCN(c2ccc(Nc3ncc4c(=O)n(C)nc(-c5ccccc5)c4n3)cc2)CC1,,CCCCO,,,,val
US20020103371A1,CC(C)c1ccc2[nH]c(=O)oc(=O)c2c1.COc1ccc(CNCC(=O)O)c(OC)c1>>COc1ccc(CN2CC(=O)Nc3ccc(C(C)C)cc3C2=O)c(OC)c1,,Cc1ccc(C)cc1,,,,val
US20070275935A1,CC(C)c1ccc(CON2C(=O)c3ccccc3C2=O)cc1.Cl>>CC(C)c1ccc(CON)cc1.Cl,,CC(=O)O,,,,val
US20080015231A1,CC(C)I.O=C(O)c1ccc(CCC[C@H]2[C@H](Cl)C[C@@H](O)[C@@H]2CCc2cc(Cl)cc(CO)c2)s1>>CC(C)OC(=O)c1ccc(CCC[C@H]2[C@H](Cl)C[C@@H](O)[C@@H]2CCc2cc(Cl)cc(CO)c2)s1,,CC(C)=O,,C1CCC2=NCCCN2CC1,,val
US20140051679A1,O=C(O)c1ccc2[nH]nc(I)c2c1.OB(O)c1ccc(N2CCOCC2)cc1>>O=C(O)c1ccc2[nH]nc(-c3ccc(N4CCOCC4)cc3)c2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20080280948A1,COc1cc([N+](=O)[O-])ccc1-n1cnc(Br)c1>>COc1cc(N)ccc1-n1cnc(Br)c1,,CCO,CCOC(C)=O,O,O=C([O-])O.[Na+],val
US20140275080A1,C=C(C)OC(=O)Cl.CC(C)(C)C(N)=O>>C=C(C)OC(=O)NC(=O)C(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20090286790A1,COc1cc(CO)cc(C(F)(F)F)c1.O=C1CCC(=O)N1Br>>COc1cc(CBr)cc(C(F)(F)F)c1,,ClCCl,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050148624A1,COC(=O)c1ccc(Cn2c(C(C)=O)c(-c3ccccc3)c3cc(Cl)ccc3c2=O)cc1>>CC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1ccc(C(=O)O)cc1,,C1CCOC1,,CO,[Na+].[OH-],val
US20090286778A1,CC(C)(C)OC(=O)Nc1cccc(C#Cc2cccc(N)c2)n1>>CC(C)(C)OC(=O)Nc1cccc(CCc2cccc(N)c2)n1,[Pd],CO,,,,val
US04271194,N#CCCl.Sc1ccc(Cl)c(Cl)c1>>N#CCSc1ccc(Cl)c(Cl)c1,,O,,[Na+].[OH-],,val
US20150225499A1,C=Cc1ccc(N)nc1.Nc1ccccn1.O=C(Cl)c1cccc(C(=O)Cl)c1>>C=Cc1ccc(NC(=O)c2cccc(C(=O)Nc3ccccn3)c2)nc1,,ClCCl,,CCN(CC)CC,,val
US20160185785A1,C[S+](C)(C)=O.O=C1CCN(C(=O)c2ccccc2)CC1>>O=C(c1ccccc1)N1CCC2(CC1)CO2,,CS(C)=O,,[H-].[Na+],,val
US20090099224A1,CCC1(OC(=O)OCc2ccccc2)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccccc1c2CC[Si](C)(C)CCCO.O=C(Cl)c1ccccc1>>CCC1(OC(=O)OCc2ccccc2)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccccc1c2CC[Si](C)(C)CCCOC(=O)c1ccccc1,CN(C)c1ccncc1,ClCCl,,,,val
US20150126485A1,CC(C)(C)OC(=O)NCC1(O)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccnn2C2CCCCO2)C1>>NCC1(O)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140088114A1,Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.O=S(=O)(c1ccccc1)C(F)(C(c1c(Cl)ccc(F)c1Cl)c1c[nH]c2ncc(Br)cc12)S(=O)(=O)c1ccccc1>>Cn1cc(-c2cnc3[nH]cc(C(c4c(Cl)ccc(F)c4Cl)C(F)(S(=O)(=O)c4ccccc4)S(=O)(=O)c4ccccc4)c3c2)cn1,,C1COCCO1,O,[F-].[K+],,val
US06350892B1,CC(C)(C)[Si](OCCCc1ccc(O)cc1)(c1ccccc1)c1ccccc1.COC(=O)C(C)(C)Br>>COC(=O)C(C)(C)Oc1ccc(CCCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cc1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030073712A1,CCOC(=O)c1ccc(C=Cc2ccc(OCOC)c(OCOC)c2)cc1>>COCOc1ccc(C=Cc2ccc(C(=O)O)cc2)cc1OCOC,,CO,,[Na+].[OH-],,val
US20120114739A1,COC(=O)C1CCC(c2cc(N)n3ncc(-c4cnc5ccccc5c4)c3n2)CN1.O=C1CCC(=O)N1Br>>COC(=O)C1CCC(c2nc3c(-c4cnc5ccccc5c4)cnn3c(N)c2Br)CN1,,CC#N,CO,,,val
US20140113916A1,N#Cc1ccc2ncn(C[C@H]3CCC[C@]4(C3)CN(c3cccc(OCc5ccccc5)c3)C(=O)O4)c2c1>>N#Cc1ccc2ncn(C[C@H]3CCC[C@]4(C3)CN(c3cccc(O)c3)C(=O)O4)c2c1,[Pd],CCO,,O=C[O-].[NH4+],,val
US05753595,CC(=O)Cl.Cn1c(C(F)(F)F)cc(=O)n(-c2c(F)cc(Cl)c3nc(N)oc23)c1=O>>CC(=O)Nc1nc2c(Cl)cc(F)c(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c2o1,,c1ccncc1,,,,val
US20080146547A1,C[O-].O=C(Nc1cccc(C(F)(F)F)c1)c1ccc2c(I)nnc(I)c2c1>>COc1nnc(I)c2ccc(C(=O)Nc3cccc(C(F)(F)F)c3)cc12,,CN(C)C=O,,Cl,,val
US20150344466A1,C#CC(C)O.CCOC(=O)C[N+](=O)[O-]>>CCOC(=O)c1cc(C(C)O)on1,,CCO,,C1CN2CCN1CC2,,val
US20090192145A1,CCOC(=O)COC1(c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)CCCc2cc(C#N)ccc21>>N#Cc1ccc2c(c1)CCCC2(OCCO)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,,CCO,,[BH4-].[Na+],,val
US20080171739A1,Brc1ccc(Br)nc1.O=C1CCCN1CCO>>O=C1CCCN1CCOc1ccc(Br)cn1,,CN1CCCC1=O,O,[Na+].[OH-],,val
US20150105366A1,O=P(Cl)(Cl)Cl.Oc1nc2ccc(I)cc2c(O)c1Cc1ccc(-n2ccnc2)cc1>>Clc1nc2ccc(I)cc2c(Cl)c1Cc1ccc(-n2ccnc2)cc1,,CC#N,,ClCCl,O=C([O-])O.[Na+],val
US20020091260A1,Cc1cccc(CCC(N)C2CCC2)c1.Cc1nc(N)nc(Cl)n1>>Cc1cccc(CCC(Nc2nc(C)nc(N)n2)C2CCC2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20030220323A1,NS(=O)(=O)c1ccccc1.O=C(O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1>>O=C(COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1)NS(=O)(=O)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US20050059673A1,COc1cccc2c(CC(C)=O)coc12.Cc1cc(N2CCNCC2)c2ncccc2c1>>COc1cccc2c(CC(C)N3CCN(c4cc(C)cc5cccnc45)CC3)coc12,,CC(=O)O,ClCCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080280933A1,CCOC(OCC)C(=N)OC.CNc1ccc(C#N)cc1N>>CCOC(OCC)c1nc2cc(C#N)ccc2n1C,,CO,,CC(=O)O,,val
US20150175623A1,CCOC(=O)[C@@H](Cc1ccccc1OC1CCCCO1)Oc1ncnc2sc(-c3ccc(F)c(COC)c3)c(-c3ccc(OCCN4CCN(C)CC4)c(Cl)c3C)c12>>CCOC(=O)[C@@H](Cc1ccccc1O)Oc1ncnc2sc(-c3ccc(F)c(COC)c3)c(-c3ccc(OCCN4CCN(C)CC4)c(Cl)c3C)c12,,CCO,,Cl,O=C([O-])O.[Na+],val
US20140155375A1,CC(C)n1cc(I)c2c(Br)ccnc21.CN1CCc2cc(F)c(B3OC(C)(C)C(C)(C)O3)cc21>>CC(C)n1cc(-c2cc3c(cc2F)CCN3C)c2c(Br)ccnc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US05843983,COc1cc(CCc2cc(F)ccc2OCC[C@@H]2C[C@@H](O)CN2C)ccc1F.Cl>>COc1cc(CCc2cc(F)ccc2OCC[C@@H]2C[C@@H](O)CN2C)ccc1F.Cl,,CCOC(C)=O,,,,val
US20080217606A1,CCO.CCOC(=O)OC.COC(OC)N(C)C.Cn1ccnc1.NN>>Cc1cn[nH]c1-c1nccn1C,,C1CCOC1,CCO,[Li]CCCC,,val
US20150359791A1,COc1ccc(OC)c2c1CCCC2C=O.O=[Cr](=O)=O>>COc1ccc(OC)c2c1CCCC2C(=O)O,,CC(C)=O,ClCCl,O=S(=O)(O)O,,val
US20120035196A1,Cc1cc(OCCOC(=O)c2ccccc2)cc(C)c1-c1cccc(C=O)c1C>>Cc1cc(OCCOC(=O)c2ccccc2)cc(C)c1-c1cccc(CO)c1C,,O,,CO,[BH4-].[Na+],val
US20100160369A1,COC(=O)c1ccc(CNC(=O)OC(C)(C)C)cc1Cl>>CC(C)(C)OC(=O)NCc1ccc(C(=O)O)c(Cl)c1,,CCO,,[Li+].[OH-],,val
US20100160648A1,COc1ccc2c(c1)CCC(c1ccccc1)=C2c1ccc(OCCN2CCCC2)cc1.Cl>>COc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1.Cl,[Pd],O,,CCO,[H][H],val
US20060189591A1,COc1ccc(Br)cn1.N#C[Cu]C#N>>COc1ccc(C#N)cn1,,CN(C)C=O,,,,val
US05733476,BrBr.CCCCCCCCC1Cc2ccccc2O1>>CCCCCCCCC1Cc2cc(Br)ccc2O1,,ClCCl,,O,O=C([O-])O.[Na+],val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2ccc(O)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21.Cc1ccc(S(=O)(=O)Cl)cc1C>>Cc1ccc(S(=O)(=O)Oc2ccc(-c3cc4cc(CN5CCCCC5)ccc4n3C(=O)OC(C)(C)C)c3c2CNC3=O)cc1C,,CC#N,,CCN(CC)CC,,val
US20120116075A1,CN1CCNCC1.Cc1ccc(NC(=O)c2ccc(CBr)c(C(F)(F)F)c2)cc1NC(=O)C=Cc1cccnc1>>Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)C=Cc1cccnc1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20070060563A1,Nc1ccncn1.O=C(Br)CBr>>O=C(CBr)Nc1ccncn1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20060025414A1,CN=C=S.Clc1cccc(-c2nc(C3COCCN3)no2)c1>>CNC(=S)N1CCOCC1c1noc(-c2cccc(Cl)c2)n1,,ClC(Cl)Cl,ClCCl,,,val
US20050119320A1,CC(=O)C(Br)c1cccc([N+](=O)[O-])c1.CC(=O)NC(N)=S>>CC(=O)Nc1nc(C)c(-c2cccc([N+](=O)[O-])c2)s1,,CCO,,,,val
US04304770,CCOC(=O)C(=NO)c1csc(N)n1.O=CO>>CCOC(=O)C(=NO)c1csc(NC=O)n1,,O=CO,,CC(=O)OC(C)=O,,val
US20110053959A1,C[C@@H]1CCc2ncnc(N3CC4(CCCN(C(=O)OC(C)(C)C)C4)c4cc(F)ccc43)c21.Cl.ClCCl>>C[C@@H]1CCc2ncnc(N3C[C@@]4(CCCNC4)c4cc(F)ccc43)c21.Cl.Cl,,C1COCCO1,ClCCl,,,val
US20140142085A1,CC(=O)Cl.Nc1cc(-c2cccnc2[C@H](Cc2cc(F)cc(F)c2)NC(=O)Cc2c[nH]c3ccc(F)cc23)ccc1F>>CC(=O)Nc1cc(-c2cccnc2[C@H](Cc2cc(F)cc(F)c2)NC(=O)Cc2c[nH]c3ccc(F)cc23)ccc1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20150291549A1,Cc1cc(C=O)c(O)cc1OCc1cccc(-c2ccc3c(c2)OCCO3)c1Cl.N#Cc1cncc(CCl)c1>>Cc1cc(C=O)c(OCc2cncc(C#N)c2)cc1OCc1cccc(-c2ccc3c(c2)OCCO3)c1Cl,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150072980A1,COc1cc2c(cc1N1CCOCC1)CCC2=O.O=Cc1cc(Br)cc(OC(F)(F)F)c1>>COc1cc2c(cc1N1CCOCC1)C/C(=C\c1cc(Br)cc(OC(F)(F)F)c1)C2=O,,CCOC(C)=O,Cc1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,,val
US20040162303A1,COc1ccc(F)cc1C(=O)c1cnc(NC2CCNCC2)nc1N.Cc1cc(S(=O)(=O)Cl)c(C)s1>>COc1ccc(F)cc1C(=O)c1cnc(NC2CCN(S(=O)(=O)c3cc(C)sc3C)CC2)nc1N,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,,val
US20070232583A1,C1CCNC1.O=S(=O)(Cl)c1cccc(-c2cc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)ccn2)c1>>O=S(=O)(c1cccc(-c2cc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)ccn2)c1)N1CCCC1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20080081833A1,N#CC1CSCC1=O.NNc1ccccc1>>Nc1c2c(nn1-c1ccccc1)CSC2,,CCO,,Cl,,val
US20020037888A1,C=CCBr.CCC1(c2cccc(OCc3ccccc3)c2)CCCCNC1=O>>C=CCN1CCCCC(CC)(c2cccc(OCc3ccccc3)c2)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US08334292B1,CC1(C)OB(c2ccc(O)cc2)OC1(C)C.Cc1ccc(S(=O)(=O)O[C@H]2CCOC2)cc1>>CC1(C)OB(c2ccc(O[C@@H]3CCOC3)cc2)OC1(C)C,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20040121964A1,CC(C)(C)OC(=O)NC1CCN(C(=O)c2ccc(Cl)cc2)CC1>>NC1CCN(C(=O)c2ccc(Cl)cc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040248872A1,CC(CCOC(=O)c1cnc(S(C)(=O)=O)nc1C)=C(F)F.CCCCNC>>CCCCN(C)c1ncc(C(=O)OCCC(C)=C(F)F)c(C)n1,,O,,CN(C)C=O,,val
US04894385,COC(=O)c1ccc(S)cc1.FC(F)(F)c1ccc(C(Cl)Cn2ccnc2)cc1>>COC(=O)c1ccc(SC(Cn2ccnc2)c2ccc(C(F)(F)F)cc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20140323487A1,O=[N+]([O-])c1cccc(Br)c1.OB(O)c1cc(F)c(CNC2Cc3ccccc3C2)c(F)c1>>O=[N+]([O-])c1cccc(-c2cc(F)c(CNC3Cc4ccccc4C3)c(F)c2)c1,,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20140275172A1,CI.COC(=O)c1cc(F)cc2cc(CCO)oc12>>COCCc1cc2cc(F)cc(C(=O)OC)c2o1,,CN(C)C=O,,[H-].[Na+],,val
US06610692B1,CC(C)(C)OC(=O)N1C[C@@H](NC(=O)OCc2ccccc2)[C@H](c2ccccn2)C1>>CC(C)(C)OC(=O)N1C[C@@H](N)[C@H](c2ccccn2)C1,[Pd],CCO,,,,val
US20050154042A1,CC(C)n1c(CCC2C[C@@H](O)CC(=O)O2)c(-c2ccc(F)cc2)c(-c2ccccc2)c1C(=O)Nc1ccccc1.CCO.[Na+]>>CC(C)n1c(CCC(O)C[C@@H](O)CC(=O)[O-])c(-c2ccc(F)cc2)c(-c2ccccc2)c1C(=O)Nc1ccccc1.[Na+],,CO,ClCCl,O,,val
US20090324581A1,COC(=O)c1ccc(C(C)C)c(OC(F)(F)F)c1>>CC(C)c1ccc(CO)cc1OC(F)(F)F,,C1CCOC1,,Cl,[BH4-].[Li+],val
US20110245272A1,C=Cc1ccc(C(F)(F)F)nc1.c1cnc2[nH]c3c(c2c1)C1CCCN1CC3>>FC(F)(F)c1ccc(CCn2c3c(c4cccnc42)C2CCCN2CC3)cn1,,CN1CCCC1=O,O,[K+].[OH-],,val
US05939439,CC(C)(C)OC(=O)NCCBr.COC(=O)c1ccc(C#N)c(O)c1>>COC(=O)c1ccc(C#N)c(OCCNC(=O)OC(C)(C)C)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080275097A1,Cc1ccnc(N)c1Oc1cc(Cl)cc(Br)c1.O=S(=O)(O)O>>Cc1ccnc(O)c1Oc1cc(Cl)cc(Br)c1,,O,O=S(=O)(O)O,O=N[O-].[Na+],,val
US20110034507A1,Cc1ccc(CBr)cc1C(=O)OC(C)(C)C.c1ccc(COc2ccc3[nH]ccc3c2)cc1>>Cc1ccc(Cn2ccc3cc(OCc4ccccc4)ccc32)cc1C(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20060257980A1,CCN(CC)C(=O)c1ccc(OC)cc1C.CCOC(=O)c1nccs1>>c1ccc2cnccc2c1,,C1CCOC1,,[Li]CCCC,,val
US20110306700A1,CCCCCCCC(=O)Cl.CCO[Si](C)(C)CCCS>>CCCCCCCC(=O)SCCC[Si](C)(C)OCC,,C1CCCCC1,,CCN(CC)CC,,val
US20040034232A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc2ncccc2c1>>CC(C)(C)OC(=O)Nc1ccc2ncccc2c1,CN(C)c1ccncc1,CCOC(C)=O,,C1COCCO1,[Na+].[OH-],val
US20060178377A1,Cc1nc2nc(C(N)=O)cn2c(-c2ccc(Cl)cc2Cl)c1C(=O)OC(C)(C)C>>Cc1nc2nc(C#N)cn2c(-c2ccc(Cl)cc2Cl)c1C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20090156512A1,[N-]=[N+]=NC[C@@H]1CCCN1C(=O)c1ccc(Br)cc1>>NC[C@@H]1CCCN1C(=O)c1ccc(Br)cc1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070287712A1,CC(C)(C)OC(=O)N1CCN(C(=C(C#N)C#N)c2ccccc2)CC1>>N#CC(C#N)=C(c1ccccc1)N1CCNCC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US06936602B1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3)cc1.O=Cc1ccccc1F>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3Cc2ccccc2F)cc1,,ClCCCl,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150111857A1,Br[Mg]Cc1ccccc1.CON(C)C(=O)c1cnc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1>>CC(C)(C)OC(=O)N1CCN(c2ncc(C(=O)c3ccccc3)cn2)CC1,,C1CCOC1,,,,val
US20110124921A1,ClP(Cl)(Cl)(Cl)c1ccccc1.O=P(O)(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>O=P(Cl)(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,,ClC(Cl)Cl,,,,val
US20120015950A1,CCC1(CC#N)CCN(C(=O)OC(C)(C)C)CC1>>CCC1(CCN)CCN(C(=O)OC(C)(C)C)CC1,[Ni],CO,,,,val
US20080153812A1,C=CCN1CCCN(c2ncc(C(=O)OC)cn2)CC1.COc1cc(CCc2cc(N)[nH]n2)cc(OC)c1>>C=CCN1CCCN(c2ncc(C(=O)Nc3cc(CCc4cc(OC)cc(OC)c4)n[nH]3)cn2)CC1,,Cc1ccccc1,,C[Al](C)C,,val
US04479942,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O.COC(=O)CCl>>COC(=O)COc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20160039814A1,COc1ncccc1-c1nc2cc(C)ccn2c1-c1ccc(NC(=O)C(C)N(C)C(=O)OC(C)(C)C)nc1C#Cc1ccc2c(C)nccc2c1>>CNC(C)C(=O)Nc1ccc(-c2c(-c3cccnc3OC)nc3cc(C)ccn23)c(C#Cc2ccc3c(C)nccc3c2)n1,,Cc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,val
US20080119518A1,C=CCBr.Oc1cccc(Br)c1>>C=CCOc1cccc(Br)c1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20100305096A1,CC(C)(C)OC(=O)N1CC(=O)C1.FC1CCNCC1>>CC(C)(C)OC(=O)N1CC(N2CCC(F)CC2)C1,,ClCCCl,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150203486A1,Brc1cnc(I)nc1.O=C1CCOC1>>OC1(c2ncc(Br)cn2)CCOC1,,Cc1ccccc1,O,[Li]CCCC,,val
US20090069319A1,CC(C)(C)OC(=O)N1CCC(N)CC1.O=[N+]([O-])c1cc(Br)cnc1Br>>CC(C)(C)OC(=O)N1CCC(Nc2ncc(Br)cc2[N+](=O)[O-])CC1,,CCOC(C)=O,CS(C)=O,,,val
US20010021714A1,COC(=O)CBr.Oc1ccc2c(c1)OCO2>>COC(=O)COc1ccc2c(c1)OCO2,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050137243A1,O=[N+]([O-])c1ccc2c(Cl)nn(CCN3CCCC3)c2c1>>Nc1ccc2c(Cl)nn(CCN3CCCC3)c2c1,[Fe],CCO,,[Cl-].[NH4+],,val
US20090162319A1,Cc1cc(Br)cc(C)c1Sc1nc(N(C(=O)OC(C)(C)C)c2ccc(C#N)cc2)nc(/C=C/N(C)C)c1[N+](=O)[O-]>>Cc1cc(Br)cc(C)c1Sc1nc(N(C(=O)OC(C)(C)C)c2ccc(C#N)cc2)nc2cc[nH]c12,,C1CCOC1,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20080262230A1,FC(F)(F)c1cc(COCC2(c3ccccc3)OCCO2)cc(C(F)(F)F)c1>>O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1,,C1CCOC1,,Cl,,val
US05106863,CC(C)=CCC/C(C)=C/CSc1nc2ccccc2[nH]1.COc1c(C)cnc(CCl)c1C>>COc1c(C)cnc(Cn2c(SC/C=C(\C)CCC=C(C)C)nc3ccccc32)c1C,,CN(C)C=O,ClCCl,,,val
US20120309739A1,COc1ccc(Cn2cc(Cl)nc(C#Cc3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c2=O)cc1.II>>CC(C)(C)OC(=O)NC1(c2ccc(-c3oc4ncc(Cl)nc4c3I)cc2)CCC1,,ClCCl,,,,val
US04943574,O=C(Cl)c1ccc(F)c([N+](=O)[O-])c1.c1ccccc1>>O=C(c1ccccc1)c1ccc(F)c([N+](=O)[O-])c1,,c1ccccc1,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US06723722B1,CC(=O)OC(C)=O.CN(C1CCN(c2ccncc2)CC1)N1C(=O)CN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CC1CN.Cl.Cl>>CC(=O)NCC1CN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CC(=O)N1N(C)C1CCN(c2ccncc2)CC1.Cl.Cl,,ClCCl,,CCN(CC)CC,,val
US20090093476A1,COC(=O)c1cc(-c2ccccc2)cn1-c1cc(C)ccc1[N+](=O)[O-]>>Cc1ccc2[nH]c(=O)c3cc(-c4ccccc4)cn3c2c1,[Fe],CC(=O)O,,,,val
US05858995,CO.Cc1oc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1CCl>>C=C1c2cccc(NC(=O)c3c(Cl)cccc3Cl)c2OC1(C)OC,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US20110178063A1,CC(C)n1nccc1C(=O)Nc1cc(B2OC(C)(C)CC(C)(C)O2)cc2nn(C3CCCCO3)cc12.Fc1cc(Br)c2cc[nH]c2c1>>CC(C)n1nccc1C(=O)Nc1cc(-c2cc(F)cc3[nH]ccc23)cc2[nH]ncc12,,C1COCCO1,CO,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20110105462A1,CCCNCCC.Cc1ccc(S(=O)(=O)OCC2COc3ccc(F)cc3O2)cc1>>CCCN(CCC)CC1COc2ccc(F)cc2O1,,CC#N,,,,val
US20160002248A1,NCc1ccccc1.O=C(O)c1cn(CCCCc2cc3c(I)c[nH]c3nn2)nn1>>O=C(NCc1ccccc1)c1cn(CCCCc2cc3c(I)c[nH]c3nn2)nn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120225857A1,CC(C)(C)OC(=O)N1CCc2cc(Cl)ncc2C1.O>>CC(C)(C)OC(=O)N1CCc2cc(Cl)ncc2C1=O,,CC#N,ClCCl,,,val
US20090030012A1,CC(C)(C)OC(=O)N1CC=C(c2nccc(-c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)CC1>>CC(C)(C)OC(=O)N1CCC(c2nccc(-c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)CC1,[Pd],CCOC(C)=O,,,,val
US20040162303A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OC1CN(C(c2ccccc2)c2ccccc2)C1>>CC(C)(C)OC(=O)N1CCC1O,[Pd],,,CCOC(C)=O,,val
US20100216798A1,Clc1ccc2ncc(-c3ccncc3)n2n1.N[C@@H](CO)[C@@H](O)c1ccccc1>>OC[C@H](Nc1ccc2ncc(-c3ccncc3)n2n1)[C@@H](O)c1ccccc1,,CS(C)=O,,,,val
US20140094459A1,CN(C(=O)OC(C)(C)C)C(C)(C)C=O.N#CCC(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21>>CN(C(=O)OC(C)(C)C)C(C)(C)C=C(C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21,CC(=O)O,C1COCCO1,,C1CCNCC1,,val
US20120264735A1,CC(c1cccc(-c2ncc(OC3CCN(C(=O)OC(C)(C)C)CC3)cn2)c1)c1nn(-c2cnn(C)c2)ccc1=O>>CC(c1cccc(-c2ncc(OC3CCNCC3)cn2)c1)c1nn(-c2cnn(C)c2)ccc1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030119847A1,C1CNCCN1.OC1(c2nccc(Cl)n2)CC2CCC(C1)N2C(c1ccccc1Cl)c1ccccc1Cl>>OC1(c2nccc(N3CCNCC3)n2)CC2CCC(C1)N2C(c1ccccc1Cl)c1ccccc1Cl,,CCO,,,,val
US20160066574A1,CC#N.CCOC(=O)C(C)(C)C#N>>CC(C)(C#N)C(=O)CC#N,,C1CCOC1,,CC(=O)O,[Li]CCCC,val
US20090240052A1,COC(=O)c1ccc(/C=C/c2ccccc2)cc1NC(=O)c1ccccc1>>O=C(Nc1cc(/C=C/c2ccccc2)ccc1C(=O)O)c1ccccc1,,C1CCOC1,,CO,[Na+].[OH-],val
US20040185215A1,BrC(Br)(Br)Br.CCCCOc1ccc(/C=C/C(=O)OCCCCCCOc2cc(CO)cc(OCCCCCCOC(=O)/C=C/c3ccc(OCCCC)c(OC)c3)c2)cc1OC>>CCCCOc1ccc(/C=C/C(=O)OCCCCCCOc2cc(CBr)cc(OCCCCCCOC(=O)/C=C/c3ccc(OCCCC)c(OC)c3)c2)cc1OC,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05395832,CCOC(=O)N1CC[C@H](N)[C@H](OC)C1.COc1cc(C(=O)O)cc(Cl)c1N>>CCOC(=O)N1CC[C@H](NC(=O)c2cc(Cl)c(N)cc2OC)[C@H](OC)C1,,C1CCOC1,,CCN(CC)CC,CCOC(=O)Cl,val
US20040214832A1,COc1ccccc1CSCCCOc1ccc(N2CCN(C(=O)OC(C)(C)C)C[C@@H]2COc2ccc3ccccc3c2)cc1>>COc1ccccc1CSCCCOc1ccc(N2CCNC[C@@H]2COc2ccc3ccccc3c2)cc1,,C1COCCO1,,Cl,O=C([O-])O.[Na+],val
US20140107340A1,N#CC(c1ccc(C(F)(F)F)nc1)C1CC1>>NCC(c1ccc(C(F)(F)F)nc1)C1CC1,,C1CCOC1,,,,val
US20150291563A1,Fc1ccc(N2N=C(C(F)(F)C(F)(F)F)CC2c2cccc(N3CCNCC3)c2)c(F)c1.O=S(=O)(Cl)C1CC1>>O=S(=O)(C1CC1)N1CCN(c2cccc(C3CC(C(F)(F)C(F)(F)F)=NN3c3ccc(F)cc3F)c2)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US20110124636A1,CC(C)(C)OC(=O)N1[C@H](CNc2ncc(Br)cn2)C[C@@H]2C[C@@H]21>>Brc1cnc(NC[C@@H]2C[C@@H]3C[C@@H]3N2)nc1,,C1COCCO1,,Cl,,val
US20090156607A1,Cc1nc2cc(-c3ccccc3)nn2c(Cl)c1F>>Cc1nc2cc(-c3ccccc3)nn2cc1F,[Zn],CC(=O)O,,,,val
US20160129002A1,C=C(OCC)c1cc(COCC2CC2)nc(Nc2ccc(-n3cnc(C)c3)c(OC)c2)n1>>COc1cc(Nc2nc(COCC3CC3)cc(C(C)=O)n2)ccc1-n1cnc(C)c1,,C1COCCO1,,Cl,O,val
US20100267666A1,O=[N+]([O-])c1cc(O)cc(Br)c1>>Nc1cc(O)cc(Br)c1,[Fe],CCO,,O,[Cl-].[NH4+],val
US20080051416A1,Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cc1C(=O)O.Nc1ccc(F)c(F)c1>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cc1C(=O)Nc1ccc(F)c(F)c1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140170207A1,CC(C)(Br)C(=O)Br.CCCCCCCCCCCC(C)O>>C=C(CCCCCCCCCCC)OC(=O)C(C)Br,,Cc1ccccc1,,CCN(CC)CC,,val
US20070173526A1,CCC1CC(N(C#N)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nc(C(F)(F)F)ccc2N1C(=O)OC(C)C.CCO.NO>>CC[C@H]1C[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2noc(C)n2)c2nc(C(F)(F)F)ccc2N1C(=O)OC(C)C,,CCO,,CCN(CC)CC,Cl,val
US20040142999A1,N#CCNC(=O)[C@@H](O)CS(=O)(=O)Cc1ccccc1OC(F)F.O=C=NC(=O)C(Cl)(Cl)Cl>>N#CCNC(=O)[C@H](CS(=O)(=O)Cc1ccccc1OC(F)F)OC(N)=O,,C1CCOC1,ClCCl,,,val
US04389412,CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)Cl.OCc1cccc(Oc2ccc(Cl)cc2)c1>>CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)OCc1cccc(Oc2ccc(Cl)cc2)c1,,c1ccccc1,,c1ccncc1,,val
US20160045505A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)Nc1cnc2nc(-c3cc(N)ccc3F)cn2c1>>CC(=O)Nc1ccc(F)c(-c2cn3cc(NC(=O)OC(C)(C)C)cnc3n2)c1,,ClCCl,,CCN(CC)CC,,val
US20070287725A1,CCOCC(=O)Cl.Nc1c(Cl)nc2ccccc2c1NCCc1cc(-c2ccc(F)cc2)no1>>CCOCC(=O)Nc1c(Cl)nc2ccccc2c1NCCc1cc(-c2ccc(F)cc2)no1,,ClCCl,,CCN(CC)CC,,val
US04808605,CI.C[C@@H](CCCCC(=O)O)NC(=O)OCc1ccccc1>>C[C@@H](CCCCC(=O)O)N(C)C(=O)OCc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20090270436A1,Cc1nn(-c2ccccn2)c(Cl)c1C=O.O=C(O)CS>>Cc1nn(-c2ccccn2)c2sc(C(=O)O)cc12,,CCO,,[K+].[OH-],,val
US20050221318A1,BrCc1ccccc1.CC(C)(C)OC(=O)NCc1ccc(C(=O)O)cc1>>CC(C)(C)OC(=O)NCc1ccc(C(=O)OCc2ccccc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04031232,CCOC(CCl)OCC.Cc1ccc(S)cc1>>CCOC(CSc1ccc(C)cc1)OCC,,CC(=O)N(C)C,,[Na],,val
US20090156600A1,CC(=O)CC(C)=O.CS(=O)(=O)c1ccc(CBr)c(Cl)c1>>CC(=O)C(Cc1ccc(S(C)(=O)=O)cc1Cl)C(C)=O,,CN(C)C=O,O,[H-].[Na+],,val
US20150166521A1,COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3occc3C)c2)c1>>Cc1ccoc1C(=O)Nc1cccc(C#Cc2cc(C(=O)N=S(C)(=O)CCCCC(=O)O)cnc2N)c1,,C1CCOC1,,Cl,[K+].[OH-],val
US05817671,CN1CCC(c2c[nH]c3ccc(N)nc23)CC1.O=C(Cl)c1ccc(F)cc1>>CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1,,c1ccncc1,,,,val
US20130252963A1,COC(=O)/C(=C\O)Cc1cn(C)c2ccccc12.NC(N)=S>>Cn1cc(Cc2c[nH]c(=S)[nH]c2=O)c2ccccc21,,CO,,,,val
US20010049367A1,ClCCCBr.O=C(c1ccc(O)cc1)C1CC1>>O=C(c1ccc(OCCCCl)cc1)C1CC1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20020087030A1,BrBr.Cc1ccc(C)cc1>>Cc1ccc(C)c(Br)c1,[Fe],,,,,val
US20130172292A1,BrCc1ccccc1.CON(C)C(=O)c1ccc(O)cn1>>CON(C)C(=O)c1ccc(OCc2ccccc2)cn1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20020064735A1,Nc1cc(Cl)c([N+](=O)[O-])cc1O.O=C(Cl)c1ccc(F)c(F)c1>>O=C(Nc1cc(Cl)c([N+](=O)[O-])cc1O)c1ccc(F)c(F)c1,,CCOC(C)=O,,,,val
US20120077811A1,COc1ccc(CNc2cc3c(Nc4ccc(F)c(Br)c4)ncnc3cn2)cc1>>Nc1cc2c(Nc3ccc(F)c(Br)c3)ncnc2cn1,,O=C(O)C(F)(F)F,,COc1ccccc1,,val
US05599483,CCCCCCCCCCCCN.O=C1CCO1>>CCCCCCCCCCCCNC(=O)C(C)O,,CCCCCC,,C1COCCO1,,val
US04973734,CC(C#N)c1ccccc1.O=[N+]([O-])c1ccc(Cl)cc1>>CC(C#N)(c1ccccc1)c1ccc([N+](=O)[O-])cc1,,c1ccncc1,,[K+].[OH-],,val
US20020016326A1,N#Cc1ccccc1F.OC1(C(F)(F)F)CC(c2ccco2)NN1>>N#Cc1ccccc1-n1nc(C(F)(F)F)cc1-c1ccco1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04118386,O=P(OC1=Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1)(N1CCOCC1)N1CCOCC1.[C-]#[N+]CC(=O)OCC>>CCOC(=O)c1ncn2c1CN=C(c1ccccc1Cl)c1cc(Cl)ccc1-2,,CC(=O)O,O,C1CCOC1,CC(C)(C)[O-].[K+],val
US20150336949A1,CC(=O)Cl.Cc1ccc(S(=O)(=O)n2cc(-c3c(C)nn(Cc4cccc(F)c4)c3C)c3cc(-c4ccc(N5CCNCC5)cc4)cnc32)cc1>>CC(=O)N1CCN(c2ccc(-c3cnc4c(c3)c(-c3c(C)nn(Cc5cccc(F)c5)c3C)cn4S(=O)(=O)c3ccc(C)cc3)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US05273999,COc1ccc2c3c(ccc2c1)OC(=O)CC3>>O=C1CCc2c(ccc3cc(O)ccc23)O1,,CCO,CCOC(C)=O,,,val
US20080085895A1,CC(C)(C)OC(=O)NCCC[C@@H](CO[Si](C)(C)C(C)(C)C)Nc1c([N+](=O)[O-])cnc2ccccc12>>CC(C)(C)OC(=O)NCCC[C@@H](CO[Si](C)(C)C(C)(C)C)Nc1c(N)cnc2ccccc12,[Pt],CC#N,,,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(O)C(F)(F)F)CC2)c2ncnn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(O)C(F)(F)F)CC2)c2ncnn12,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20150111894A1,COc1cc(-n2ccc3oc(Br)cc3c2=O)ccc1OCC1(C#N)CC1.OB(O)c1ccccc1F>>COc1cc(-n2ccc3oc(-c4ccccc4F)cc3c2=O)ccc1OCC1(C#N)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US05478826,C[C@@H](NCCOCc1ccccc1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F.O=C(Cl)c1ccc(C(F)(F)F)cc1>>C[C@@H](N(CCOCc1ccccc1)C(=O)c1ccc(C(F)(F)F)cc1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F,,ClCCl,,CCN(CC)CC,,val
US05892104,CC1=CC(C)(C)CC(O)CC1.CI>>COC1CCC(C)=CC(C)(C)C1,,Cc1ccccc1,,[H-].[Na+],,val
US20090048203A1,CC(=O)OC(C)(C)C(=O)Cl.C[C@H]1O[C@@H](n2cnc3c(N)nc(OCC4CC45CC5)nc32)[C@H](O)[C@@H]1O>>C[C@H]1O[C@@H](n2cnc3c(N)nc(OCC4CC45CC5)nc32)[C@H](O)[C@H]1Cl,,CC#N,O,,,val
US04996202,CN1CCc2cc(Cl)c(NC=O)cc2[C@@H](c2ccccc2)C1>>CNc1cc2c(cc1Cl)CCN(C)C[C@@H]2c1ccccc1,,C1CCOC1,,CSC,,val
US20090247596A1,Clc1cccc([Mg]Br)c1.O=Cc1cc(Cl)sc1Br>>OC(c1cccc(Cl)c1)c1cc(Cl)sc1Br,,C1CCOC1,CCOCC,,,val
US05668136,Cc1cccc(O)c1[N+](=O)[O-].ClCCCn1cnc(-c2ccccc2)c1>>Cc1cccc(OCCCn2cnc(-c3ccccc3)c2)c1[N+](=O)[O-],,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20080221096A1,CC1(C)CCc2c(N3CCOCC3)[nH]c(=O)c(C#N)c2C1.CCOC(=O)CBr>>CCOC(=O)COc1nc(N2CCOCC2)c2c(c1C#N)CC(C)(C)CC2,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120010188A1,Nc1cc(Cl)ccn1.O=C(CBr)c1ccc(Br)cc1>>Br.Clc1ccn2cc(-c3ccc(Br)cc3)nc2c1,,CCO,,,,val
US04096267,CI.O=C(O)COc1cc2c(c(Cl)c1Cl)C(=O)C(c1ccccc1)C2>>CC1(c2ccccc2)Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1=O,,CN(C)C=O,,Cl,[H-].[Na+],val
US20070043036A1,BrCCCBr.Cc1c(O)cc(C(=O)NCc2ccc(S(=O)(=O)C(C)C)cc2)c(=O)n1-c1cccc(C(F)(F)F)c1>>Cc1c(OCCCBr)cc(C(=O)NCc2ccc(S(=O)(=O)C(C)C)cc2)c(=O)n1-c1cccc(C(F)(F)F)c1,,CN(C)C=O,,,,val
US20120058997A1,CN1CCC(O)(CN)CC1.FC(F)(F)Oc1cccc(-c2cnc3ccc(Cl)nn23)c1>>CN1CCC(O)(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1,,CS(C)=O,,[Cs+].[F-],,val
US20020177599A1,C#C[Si](C)(C)C.CCCCOc1ncc(I)cc1-c1nc2c(CC)n(CCN(C)C)nc2c(=O)[nH]1>>CCCCOc1ncc(C#C[Si](C)(C)C)cc1-c1nc2c(CC)n(CCN(C)C)nc2c(=O)[nH]1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,CCN(CC)CC,,,val
US20110251190A1,CC(C)(C)OC(=O)NC1=N[C@@]2(CS1)c1cc(-c3cccnc3F)ccc1Oc1cnc(Cl)cc12.FC1(F)CCNC1>>CC(C)(C)OC(=O)NC1=N[C@@]2(CS1)c1cc(-c3cccnc3F)ccc1Oc1cnc(N3CCC(F)(F)C3)cc12,,CCOC(C)=O,O,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20120220593A1,CC(C)Oc1ccc(/C=C(\NC(=O)c2ccc(OCCc3ccc(N(C)C)cc3)cc2)C(=O)NCCO)cc1.Cl>>CC(C)Oc1ccc(/C=C(\NC(=O)c2ccc(OCCc3ccc(N(C)C)cc3)cc2)C(=O)NCCO)cc1.Cl,,CO,,CCOC(C)=O,,val
US06057337,CCCCCCCCCCCCCCCCCC(=O)N1CCCCC1CCON(C=O)CCCN1CCOCC1.Cl>>CCCCCCCCCCCCCCCCCC(=O)N1CCCCC1CCON(C=O)CCCN1CCOCC1.Cl,,CCOC(C)=O,,,,val
US20080255134A1,CC(C)(C)OC(=O)N1CCC(N)CC1.c1ccc(OC[C@@H]2CO2)cc1>>CC(C)(C)OC(=O)N1CCC(NC[C@H](O)COc2ccccc2)CC1,,CCO,,,,val
US20070232583A1,CC(C)(C)COS(=O)(=O)c1cccc(-c2cc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)ccn2)c1.Cl>>Cl.O=S(=O)(O)c1cccc(-c2cc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)ccn2)c1,,C1COCCO1,,,,val
US05006548,CCOC(=O)c1ccccc1N.O=C(O)C=Cc1ccco1>>CCOC(=O)c1ccccc1NC(=O)C=Cc1ccco1,,ClCCl,,CCN(CC)CC,C[n+]1ccccc1Cl.[I-],val
US20040152690A1,CC(=O)Nc1ccc(Br)c(C(F)(F)F)c1.O=[N+]([O-])O>>CC(=O)Nc1cc(C(F)(F)F)c(Br)cc1[N+](=O)[O-],,O=S(=O)(O)O,,O=C([O-])O.[Na+],,val
US06114391,COc1cc2c(cc1OC)C(=O)C(=NO)C2>>COc1cc2c(cc1OC)CC(N)C2,[Pd],CC(=O)O,O,O=S(=O)(O)O,,val
US20090197884A1,COc1ccc(N)cn1.C[N+]1(Cc2ccccc2)CCC(=O)CC1>>COc1ccc(N2CCC(=O)CC2)cn1,,CCO,O,[I-].[K+],,val
US05229516,CCCC(=O)CC(=O)OCC.OCCc1c[nH]c2ccc(OCc3ccccc3)cc12>>CCCC1(CC(=O)OCC)OCCc2c1[nH]c1ccc(OCc3ccccc3)cc21,,ClCCl,,CCOCC,FB(F)F,val
US20100160304A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=[N+]([O-])c1ccc(O)cc1>>Cc1ccc(S(=O)(=O)Oc2ccc([N+](=O)[O-])cc2)cc1,,CC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US03974153,CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(COC(N)=O)CS[C@H]12)c1ccco1>>CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(N)=O)CS[C@H]12)c1ccco1,,O=C(O)C(F)(F)F,,COc1ccccc1,,val
US20060004069A1,CCCn1cnnc1CSc1ccc(NC(=O)/C=C/c2cnn(C)c2-c2ccc(F)cc2)cc1.O=C(OO)c1cccc(Cl)c1>>CCCn1cnnc1CS(=O)c1ccc(NC(=O)/C=C/c2cnn(C)c2-c2ccc(F)cc2)cc1,,C1CCOC1,,,,val
US20010012844A1,Nc1ccccc1.Nc1nc(N)c2c(F)cccc2n1>>Nc1nc(N)c2c(Nc3ccccc3)cccc2n1,,CS(C)=O,,[H-].[Na+],,val
US08912186B2,Nc1ccc(Cl)cc1N.O=C(O)CCl>>ClCc1nc2ccc(Cl)cc2[nH]1,,Cl,,,,val
US20140256700A1,BrCC1CCC1.Cc1noc(C)c1-c1cc(C(N)=O)c2c(c1)[nH]c1ccc(C(=O)N3C[C@H](C)O[C@H](C)C3)cc12>>Cc1noc(C)c1-c1cc(C(N)=O)c2c3cc(C(=O)N4C[C@H](C)O[C@H](C)C4)ccc3n(CC3CCC3)c2c1,,CC(C)=O,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20100009963A1,COc1cc(F)cc(-c2n[nH]c3ncnc(N)c23)c1.IC1CCCC1>>COc1cc(F)cc(-c2nn(C3CCCC3)c3ncnc(N)c23)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US03952031,CC(=O)OC(C)=O.CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](Br)C[C@]4(C)[C@H]3CC[C@]12C>>CC(=O)O[C@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@H](C(C)=O)[C@@]4(C)CC[C@@H]3[C@@]2(C)C[C@@H]1Br,,c1ccncc1,,O,,val
US20030212276A1,N#Cc1cnc2cc(F)ccc2c1O.O=S(Cl)Cl>>N#Cc1cnc2cc(F)ccc2c1Cl,CN(C)C=O,,,,,val
US05708174,COC(=O)c1cccc2c1SCC=C2>>O=C(O)c1cccc2c1SCC=C2,,CCO,,[Na+].[OH-],,val
US20150148340A1,CCOC=C(C(=O)NC(=O)OCC)C(=O)OCC.CN1C(=O)C2(CC2)c2cc(N)ccc21>>CCOC(=O)c1cn(-c2ccc3c(c2)C2(CC2)C(=O)N3C)c(=O)[nH]c1=O,,CCO,O,Cl,CC(C)(C)[O-].[K+],val
US20050020595A1,C=CC(=O)OCC.[O-]P(OCc1ccccc1)OCc1ccccc1>>O=C(O)CCP(=O)(OCc1ccccc1)OCc1ccccc1,,C1CCOC1,,O,O=C([O-])[O-].[K+].[K+],val
US20060264460A1,N#Cc1ccc(C=O)cc1.N#Cc1cnc2c(C(F)(F)F)cc(N)cc2c1Nc1ccc(F)c(Cl)c1>>N#Cc1ccc(CNc2cc(C(F)(F)F)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)cc1,,CCO,,[BH3-]C#N.[Na+],,val
US05491167,CCC(Oc1c(Br)cccc1Br)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O3)[C@H]21>>CCC(Oc1c(Br)cccc1Br)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140249104A1,O=C(NC1=N[C@](CF)(c2cc(Br)ccc2F)C[C@@H](C(F)(F)F)O1)c1ccccc1>>NC1=N[C@](CF)(c2cc(Br)ccc2F)C[C@@H](C(F)(F)F)O1,,CO,,C1CCC2=NCCCN2CC1,,val
US20110190280A1,CCNc1nc(-c2cc(C)cc(OC)c2)c(-c2ccnc(Cl)n2)s1.Nc1ccc(N2CCN(CCF)CC2)c(F)c1>>CCNc1nc(-c2cc(C)cc(OC)c2)c(-c2ccnc(Nc3ccc(N4CCN(CCF)CC4)c(F)c3)n2)s1,,OCC(F)(F)F,,,,val
US20120142672A1,ClCCCBr.O=C(O)Cc1ccc(F)cc1Cl>>O=C(O)C(CCCCl)c1ccc(F)cc1Cl,,C1CCOC1,,[Li]CCCC,,val
US20140243526A1,CC1(C)CCC=C(C(=O)CCCCC=O)C1>>CC1(C)CCC=C(C(=O)CCCCCO)C1,,Cc1ccccc1,,,,val
US20050014822A1,CC(=O)OC(C)=O.COc1ccc(N)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl>>COc1ccc(NC(C)=O)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl,,O,,CN1CCCC1=O,,val
US20160016966A1,CC1(C)OB(c2ccncc2OCC2COC2)OC1(C)C.C[C@@H]1CN(S(C)(=O)=O)CCN1Cc1cc2c(=O)n(C)cc(Br)c2o1>>C[C@@H]1CN(S(C)(=O)=O)CCN1Cc1cc2c(=O)n(C)cc(-c3ccncc3OCC3COC3)c2o1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20070066624A1,Cc1nc(Oc2ccc(C(=O)NC3CC3)cc2)ccc1C=O.c1ccc(N=C2OC[C@@H](c3ccccc3)N2C2CCNCC2)cc1>>Cc1nc(Oc2ccc(C(=O)NC3CC3)cc2)ccc1CN1CCC(N2C(=Nc3ccccc3)OC[C@H]2c2ccccc2)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160251339A1,COc1ccc(S(=O)(=O)Cl)cc1N1CCOCC1.O=Cc1c[nH]c2cc(Br)ccc12>>COc1ccc(S(=O)(=O)n2cc(C=O)c3ccc(Br)cc32)cc1N1CCOCC1,,C1CCOC1,,[H-].[Na+],,val
US20150203493A1,CCOC(=O)C1CC(NCc2ccc3c(O[C@@H]4CC[C@@H](C(C)(C)C)CC4)cccc3c2)C1(C)C>>CC1(C)C(NCc2ccc3c(O[C@@H]4CC[C@@H](C(C)(C)C)CC4)cccc3c2)CC1C(=O)O,,CO,O,[Na+].[OH-],,val
US20110212967A1,C[C@@H](C#N)NC(=O)OC(C)(C)C.NO>>C[C@H](NC(=O)OC(C)(C)C)/C(N)=N/O,,CCO,,CCN(CC)CC,,val
US20070072865A1,NNc1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C1OC(c2ccccc2)(c2ccccc2)C2CNCCN12>>O=C(NNc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1,,C1CCOC1,O,CCN(C(C)C)C(C)C,,val
US20020147181A1,N#Cc1ccc(Nc2nc(Cl)nc(Cc3c(Cl)cccc3Cl)n2)cc1.N=C(N)N>>N#Cc1ccc(Nc2nc(Cc3c(Cl)cccc3Cl)nc(NC(=N)N)n2)cc1,,C1COCCO1,,[Na+].[OH-],,val
US20080125413A1,O=C(OCc1ccccc1)N1CCC(N2CC(c3ccncc3)NC2=O)CC1>>O=C1NC(c2ccncc2)CN1C1CCNCC1,[Pd],CCO,,[H][H],,val
US05753641,COC(=O)CCCCCCCCCCC(=O)N(C)c1ccccc1OCc1ccccc1>>COC(=O)CCCCCCCCCCC(=O)N(C)c1ccccc1O,[Pd],CO,,[H][H],,val
US20050188480A1,Nc1cccc(Nc2ccc([N+](=O)[O-])cc2)n1>>Nc1ccc(Nc2cccc(N)n2)cc1,[Pd],CO,,O=C=O,,val
US04695566,NCCN1CCOCC1.O=C(O)COc1cc(-c2ccccc2)[nH]n1>>O=C(COc1cc(-c2ccccc2)[nH]n1)NCCN1CCOCC1,,ClCCl,,CCN(CC)CC,,val
US20120046278A1,CS(=O)c1nc2c(N3CCN(C(=O)COc4ccc(Cl)cc4)CC3)nc(N)nc2s1.Nc1ccc(F)cc1>>Nc1nc(N2CCN(C(=O)COc3ccc(Cl)cc3)CC2)c2nc(Nc3ccc(F)cc3)sc2n1,,C1COCCO1,,,,val
US20120142717A1,CCc1c[nH]c(OCCc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)cc2)nc1=O.CI>>CCc1cn(C)c(OCCc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)cc2)nc1=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090143439A1,CNC(=O)Nc1cc(Br)cc(N)n1.Cc1cc(S(N)(=O)=O)cs1.O=C(Cl)Oc1ccccc1>>CNC(=O)Nc1cc(Br)cc(NC(=O)NS(=O)(=O)c2csc(C)c2)n1,,CC#N,,CCN(CC)CC,,val
US20110039823A1,C1CNCCN1.COc1ccc2ncnc(Cl)c2c1>>COc1ccc2ncnc(N3CCNCC3)c2c1,,CN(C)C=O,,,,val
US20140296271A1,C#Cc1cc(N)cc(C(=O)NCCOCCOCCOC)c1.CC(C)(C)OC(=O)Nc1ccc(Oc2ccnc(Cl)n2)c2ccccc12>>C#Cc1cc(Nc2nccc(Oc3ccc(NC(=O)OC(C)(C)C)c4ccccc34)n2)cc(C(=O)NCCOCCOCCOC)c1,,CN(C)C=O,,,,val
US20060135484A1,CC(=O)OC(C)(C)C.CCC(CC)(c1ccc(OCC(O[Si](C)(C)C(C)(C)C)C(C)(C)C)c(C)c1)c1cc(C)c(S(N)(=O)=O)s1>>CC(=O)OC(C)(C)C.CCC(CC)(c1ccc(OCC(O)C(C)(C)C)c(C)c1)c1cc(C)c(S(N)(=O)=O)s1,,CCOC(C)=O,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130172302A1,Nc1ccon1.O=C(Cl)CCl>>O=C(CCl)Nc1ccon1,,ClCCl,,,,val
US06008213,CCOC(=O)CC1=Cc2ccc(C#CCCOC3CCCCO3)cc2Cc2ccccc21>>CCOC(=O)CC1=Cc2ccc(CCCCOC3CCCCO3)cc2Cc2ccccc21,[Pd],CCOC(C)=O,,,,val
US20090227580A1,N[C@H](CO)c1ccccc1.O=C(O)CCC(=O)[C@@H]1CC[C@@H](COCc2ccccc2)CC1>>O=C1CC[C@@]2([C@@H]3CC[C@@H](COCc4ccccc4)CC3)OC[C@H](c3ccccc3)N12,,Cc1ccccc1,,O,,val
US20060257987A1,CCCC(Br)CCO.Oc1ccc2c(-c3ccccc3)coc2c1>>CCCC(CCO)Oc1ccc2c(-c3ccccc3)coc2c1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US06235771B1,CCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CCS3(=O)=O)cc1.Cl>>CCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CCS3(=O)=O)cc1.Cl,,C1CCOC1,,,,val
US05516788,CC(C)c1ccc2[nH]c3c(c2c1)Cc1ccccc1-3>>CC(C)c1ccc2c(c1)[C@H]1Cc3ccccc3[C@H]1N2,,CC(=O)O,,[Na+].[OH-],,val
US20060058325A1,COc1cc2c(Cl)ncnc2cc1OCCCCl.Nc1ccc(OCc2cccc(Cl)c2)nc1>>COc1cc2c(Nc3ccc(OCc4cccc(Cl)c4)nc3)ncnc2cc1OCCCCl,,CC(=O)N(C)C,,,,val
US20120165533A1,CC(C)(C)OC(=O)[C@@H]1CC[C@H](O)CN1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)[C@@H]1CC[C@H](O)CN1C(=O)C(F)(F)F,,C1CCOC1,,CCN(CC)CC,O,val
US06362230B1,Br[Zn]C1CCCC1.CC(CNS(=O)(=O)C(C)C)C1CC=C(c2ccc(C=O)cc2)CC1>>CC(CNS(=O)(=O)C(C)C)C1CC=C(C2CCCC2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,,,val
US20070275984A1,C[Si](C)(C)N=[N+]=[N-].Cc1nc(NCCc2ccc(OCC#N)cc2)c2cc(C)sc2n1>>Cc1nc(NCCc2ccc(OCc3nn[nH]n3)cc2)c2cc(C)sc2n1,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US20090143361A1,CC(=O)OC(C)=O.COc1ccc(N)c(-n2cnc(C)c2)n1>>COc1ccc(NC(C)=O)c(-n2cnc(C)c2)n1,,Cc1ccccc1,,,,val
US20070219235A1,CC(C)(C)OC(=O)N1CCN(c2cc(N)c(N)cc2C(=O)Nc2ccc3cn[nH]c3c2)CC1.Cc1cccnc1N=C=S>>Cc1cccnc1Nc1nc2cc(C(=O)Nc3ccc4cn[nH]c4c3)c(N3CCN(C(=O)OC(C)(C)C)CC3)cc2[nH]1,,ClCCCl,,,,val
US20030171219A1,Cc1cc(C)c(C(C(=O)O)C(=O)O)cc1C.O=S(Cl)Cl>>Cc1cc(C)c(C(=C=O)C(=O)Cl)cc1C,,Cc1ccccc1,,,,val
US20060019992A1,O=CC1(c2ccccc2)CCC=CCC1>>OCC1(c2ccccc2)CCC=CCC1,,CO,,[BH4-].[Na+],,val
US20060270713A1,CC(C)(C)OC(=O)N1CC[C@H](/N=C/c2ccccc2C(F)(F)F)C1>>CC(C)(C)OC(=O)N1CC[C@H](NCc2ccccc2C(F)(F)F)C1,[Pd],CCO,,,,val
US20120122843A1,Cc1cc(Cl)nc(Cl)c1CBr.NCC(O)C1CC1>>Cc1cc(Cl)nc(Cl)c1CNCC(O)C1CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100317659A1,CCOC(=O)c1nc(Nc2cc(C)[nH]n2)c2ccc(OC)cc2n1.Fc1ccc([Mg]Br)cc1>>COc1ccc2c(Nc3cc(C)[nH]n3)nc(C(=O)c3ccc(F)cc3)nc2c1,,CC(=O)N(C)C,,C1CCOC1,,val
US20130296302A1,Nc1c(-c2cncc(F)c2)cncc1[N+](=O)[O-]>>Nc1cncc(-c2cncc(F)c2)c1N,[Pd],CCO,,,,val
US04278683,C1CO1.O=C(NCC1(CO)NCC(O)C(O)C1O)c1ccccc1>>O=C(NCC1(CO)C(O)C(O)C(O)CN1CCO)c1ccccc1,CC(=O)O,O,,,,val
US20110274638A1,CCCCCC1(c2ccccc2)CNC1.O=C(O)C(=O)O>>CCCCCC1(C2CCCCC2)CNC1.O=C(O)C(=O)O,[Rh],C1CCOC1,O,,,val
US20080319188A1,CCN(CC)CCCN(C)C(=O)Nc1cc(Oc2ccc([N+](=O)[O-])cc2F)ccn1>>CCN(CC)CCCN(C)C(=O)Nc1cc(Oc2ccc(N)cc2F)ccn1,[Pd],CO,,C1CCOC1,,val
US20040106655A1,O=C(OCc1ccccc1)N1CCNCC1.S=C=Nc1ccccc1>>O=C(OCc1ccccc1)N1CCN(C(=S)Nc2ccccc2)CC1,,CC(C)=O,,,,val
US20100305067A1,Brc1cnc(N2CCNCC2)nc1.OCCBr>>OCCN1CCN(c2ncc(Br)cn2)CC1,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US05929067,CCOC(=O)C=CC(C(c1ccccc1)c1ccccc1)N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(C=CC(=O)O)C(c1ccccc1)c1ccccc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20090258891A1,COC(=O)[C@@H]1C[C@H](OS(=O)(=O)c2ccc(Br)cc2)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C1CCCCC1.COc1cc2[nH]c(=O)cc(O)c2cc1Br>>COC(=O)[C@@H]1C[C@@H](Oc2cc(=O)[nH]c3cc(OC)c(Br)cc23)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C1CCCCC1,,CN1CCCC1=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030134849A1,O=Cc1ccc(Br)cc1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>Brc1ccc(-c2cnco2)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20040171881A1,CCCNCC.COC(=O)c1cc(I)cc(C(=O)O)c1>>CCCN(CC)C(=O)c1cc(I)cc(C(=O)OC)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050182059A1,CCCSc1ccc(N)nn1.COCCOc1ccc(C(=O)CBr)cc1>>CCCSc1ccc2nc(-c3ccc(OCCOC)cc3)cn2n1,,CCO,,O=C([O-])O.[Na+],,val
US20070142413A1,C[C@H](Nc1nc(Nc2cc(C3CC3)[nH]n2)c2cccnc2n1)c1ccc(F)cc1>>C[C@H](Nc1nc2c(c(Nc3cc(C4CC4)[nH]n3)n1)CCCN2)c1ccc(F)cc1,O=[Pt],CCO,,,,val
US20080171772A1,CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(O)cc2n1Cc1ccccc1.COCCl>>COCOc1ccc2c(C(=O)NCc3ccc(F)c(F)c3)c(C(C)C)n(Cc3ccccc3)c2c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120238569A1,COC(=O)[C@H](CNC(=O)OC(C)(C)C)NC(=O)c1sc(C(=O)NCc2cccc3c2CC(=O)N3)cc1C(F)(F)F.O=C(O)C(F)(F)F>>COC(=O)[C@H](CN)NC(=O)c1sc(C(=O)NCc2cccc3c2CC(=O)N3)cc1C(F)(F)F.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05338756,CCCCC(=N)OCC.Nc1cncnc1N>>CCCCc1nc2cncnc2[nH]1,,CN(C)C=O,,Cl,,val
US20090209532A1,COc1cc2c(Cl)c(C(=O)N3CCOCC3)sc2c(Br)c1OC.N#C[Cu]>>COc1cc2c(Cl)c(C(=O)N3CCOCC3)sc2c(C#N)c1OC,,CN(C)C=O,,CCOC(C)=O,O,val
US20140088101A1,COC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O.NC1CC1>>O=C(NC1CC1)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O,,CCO,,CC(=O)O,O,val
US04874775,CS(=O)(=O)Cl.FC(F)(F)COc1ccc(NCc2cccnc2)cc1>>CS(=O)(=O)N(Cc1cccnc1)c1ccc(OCC(F)(F)F)cc1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20160009667A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1noc2cc(COc3ccc(Cl)c(F)c3)c(Cl)cc12>>Nc1noc2cc(COc3ccc(Cl)c(F)c3)c(Cl)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110046167A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC[C@H](O)CO>>CC(C)(C)OC(=O)NC[C@H](O)CO,,CO,,CCN(CC)CC,Cl,val
US20080194576A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CC(O)C(C)S>>CC(S)C(C)O[Si](C)(C)C(C)(C)C,,ClCCl,,Cc1cccc(C)n1,,val
US05817679,COC(=O)N1C2CCC1C(c1ccc(Cl)nc1)C2>>COC(=O)N1C2CCC1C(c1cccnc1)C2,,CO,,[H][H],,val
US20140275027A1,COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCCN(CCO[Si](C)(C)C(C)(C)C)C3)cc12>>COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCCN(CCO)C3)cc12,,ClCCl,,CO,Cl,val
US04795751,CN1CCNCC1.Nc1c(F)c(F)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1>>CN1CCN(c2c(F)c(N)c3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)CC1,,Cc1ccccc1C,,,,val
US20100280010A1,CN(Cc1nc2cccc(F)n2c1Br)[C@H]1CCCc2cccnc21.CN1CCNCC1>>CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(Br)n23)CC1,,CC#N,ClCCl,,,val
US20110245205A1,COC(=O)[C@H]1CC[C@](O)(c2nccs2)CC1(C)C.O>>CC1(C)C[C@@](O)(c2nccs2)CC[C@@H]1C(=O)O.O,,O,,Cl,[Na+].[OH-],val
US20150376212A1,COC(=O)c1ccc(COc2ccccc2Br)cc1>>O=C(O)c1ccc(COc2ccccc2Br)cc1,,O,,CO,[Na+].[OH-],val
US20060178373A1,CC(C)NCC(O)COc1ccc2c(=O)cc(-c3cc(OCc4ccccc4)cc(OCc4ccccc4)c3)oc2c1>>CC(C)NCC(O)COc1ccc2c(=O)cc(-c3cc(O)cc(O)c3)oc2c1,[Pd],CO,,,,val
US04808589,N#CCCCCl.SCc1ccco1>>N#CCCCSCc1ccco1,,CCO,O,[Na+].[OH-],,val
US05157114,Cc1ccc(C(=O)OC[C@H]2O[C@@H](n3cc(C#C[Si](C)(C)C)c(=O)[nH]c3=O)C[C@@H]2F)cc1>>C#Cc1cn([C@H]2C[C@H](F)[C@@H](CO)O2)c(=O)[nH]c1=O,,CO,,C[O-].[Na+],,val
US20100240642A1,Nc1ccccc1C#Cc1cccc(C(F)(F)F)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1ccccc1C#Cc1cccc(C(F)(F)F)c1)C(F)(F)F,,C1CCOC1,CCOC(C)=O,O=C([O-])O.[Na+],,val
US20150166558A1,N#CCCCBr.N[C@@H](Cn1c(=O)c2c(n(Cc3c(F)cccc3C(F)(F)F)c1=O)COC21CCN(Cc2cccc(Cl)c2)CC1)c1ccccc1>>N#CCCCN[C@@H](Cn1c(=O)c2c(n(Cc3c(F)cccc3C(F)(F)F)c1=O)COC21CCN(Cc2cccc(Cl)c2)CC1)c1ccccc1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20100261708A1,CC(C)(C)OC(=O)N1CCCNCC1.Clc1nc2ccccc2[nH]1>>CC(C)(C)OC(=O)N1CCCN(c2nc3ccccc3[nH]2)CC1,,CCO,,CCN(CC)CC,,val
US20110118284A1,CCN.O=C(c1cccs1)c1nc(NCc2cccnc2)nc2cc(Cl)sc12>>CCNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1,,CC(=O)N(C)C,,Cl,,val
US20010027196A1,COCCN.CS(=O)c1nc(N)nc(-c2ccco2)c1Br>>COCCNc1nc(N)nc(-c2ccco2)c1Br,,C1COCCO1,,,,val
US20140213554A1,CC1(C)OB(c2ccc(P(C)(C)=O)cc2)OC1(C)C.Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(I)cc3c2)c1C>>Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(-c4ccc(P(C)(C)=O)cc4)cc3c2)c1C,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20060167055A1,Br.COc1c(F)ccc(F)c1[C@H]1[C@H]2COC(=O)[C@H]21>>O=C1Oc2c(F)ccc(F)c2[C@@H]2[C@H](CBr)[C@H]12,,O,,CC(=O)O,,val
US20060046978A1,CC(C)(C)OC(=O)N(CC(=O)O)CC(=O)O.NC(=O)[C@@H]1CCCN1>>CC(C)(C)OC(=O)N(CC(=O)O)CC(=O)N1CCCC1C(N)=O,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20040224974A1,CCc1nn2c(Br)cccc2c1[N+](=O)[O-]>>CCc1nn2c(Br)cccc2c1N,[Zn],CC(=O)O,,CCO,O,val
US20120022043A1,Cn1cc(N)c(-c2cc(Cl)ccc2Cl)n1.O=C(Cl)c1cnn2ccc(Cl)nc12>>Cn1cc(NC(=O)c2cnn3ccc(Cl)nc23)c(-c2cc(Cl)ccc2Cl)n1,,ClCCl,,CCN(CC)CC,,val
US20080207654A1,CCCc1nc(C)n(-c2ccc(OC(C)C(=O)OC)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1>>CCCc1nc(C)n(-c2ccc(OC(C)CO)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1,,C1CCOC1,,CCOC(C)=O,O,val
US20070244131A1,COc1nc(Cl)cc(NCCc2ccc(Cl)cc2Cl)n1.O=C(O)C1(c2cccc(B(O)O)c2)CCCC1>>COc1nc(NCCc2ccc(Cl)cc2Cl)cc(-c2cccc(C3(C(=O)O)CCCC3)c2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US05162571,CCc1c(C)cc(OC)c(C)c1C>>CCc1c(C)cc(O)c(C)c1C,,O,,Br,,val
US20070185133A1,CC(C)(C)OC(=O)NCCN1C(=O)NCC1O>>NCCn1cc[nH]c1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04401675,COC(=O)Cl.Cc1cccc(C)c1NN>>COC(=O)NNc1c(C)cccc1C,,CCOCC,,CCN(CC)CC,,val
US06706725B1,CC/C(=C\CCC(CC)(CC)O[Si](CC)(CC)CC)c1cc(COc2ccc(C(=O)OC)c(C(=O)OC)c2)cs1>>CC/C(=C\CCC(O)(CC)CC)c1cc(COc2ccc(C(=O)OC)c(C(=O)OC)c2)cs1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04999381,CN(C)C(=O)c1ccc([N+](=O)[O-])cc1Cl>>CN(C)C(=O)c1ccc(N)cc1Cl,[Fe],CCO,,Cl,O,val
US20150175557A1,CC(C)(C)OC(=O)N[C@@H]1CCC(C)(O)C(C)(C)C1>>CC1(C)C[C@H](N)CCC1(C)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080261969A1,CC1(C)CC(=O)CC(=O)C1.CCOC(=O)c1[nH]ccc1N.Cc1ccc2[nH]c(Sc3ccc(C=O)o3)nc2c1>>CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CC(C)(C)C1)C2c1ccc(Sc2nc3cc(C)ccc3[nH]2)o1,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20080146625A1,CC(C)(C)OC(=O)n1nccc1N.CC(C)O/N=C(/C(=O)O)c1ccc(S(C)(=O)=O)c(Cl)c1>>CC(C)O/N=C(/C(=O)Nc1ccnn1C(=O)OC(C)(C)C)c1ccc(S(C)(=O)=O)c(Cl)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20160115158A1,Nc1cnccc1O.O=S(=O)(Cl)c1cc(Cl)sc1Cl>>O=S(=O)(Nc1cnccc1O)c1cc(Cl)sc1Cl,,CO,,,,val
US20140018326A1,CC(C)CCO.COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)NS(=O)(=O)c1ccc([N+](=O)[O-])cc1)C(c1ccccc1)c1ccccc1>>COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)N(CCC(C)C)S(=O)(=O)c1ccc([N+](=O)[O-])cc1)C(c1ccccc1)c1ccccc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150175557A1,CC(C)=O.CI.O=C1CCCC(=O)C1>>CC1(C)C(=O)CCCC1=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110301142A1,COC(=O)C(C(C)=O)C(=O)c1ccc(CCl)cc1.NO>>COC(=O)c1c(C)noc1-c1ccc(CCl)cc1,,CC(=O)O,,Cl,O=C([O-])O.[Na+],val
US20130331387A1,CCO.COC(=O)c1sc(Br)c(C)c1-c1ccc(S(N)(=O)=O)c(C)c1.OB(O)c1ccc(Cl)cc1>>CCOC(=O)c1sc(-c2ccc(Cl)cc2)c(C)c1-c1ccc(S(N)(=O)=O)c(C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US20020165218A1,Nc1ccc(N2CCOCC2)cc1N.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]c2ccc(N3CCOCC3)cc2[nH]1,,C1CCOC1,,,,val
US20110039843A1,Fc1cnccc1-c1nc2cc(C(F)(F)F)ccc2o1.OCC(F)(F)C(F)(F)F>>FC(F)(F)c1ccc2oc(-c3ccncc3OCC(F)(F)C(F)(F)F)nc2c1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20090240055A1,CC(C)(C)OC(=O)Oc1ccccc1.CC(C)(N)CN>>CC(C)(N)CNC(=O)OC(C)(C)C,,CCO,,,,val
US06255302B1,COc1ccccc1N1CCN(CC2CCNCC2)CC1.O=C(Cl)c1ccccc1>>COc1ccccc1N1CCN(CC2CCN(C(=O)c3ccccc3)CC2)CC1,,ClCCl,,CCN(CC)CC,,val
US20140296519A1,Clc1cccc2[nH]c3ccccc3c12.Clc1nc(-c2ccccc2)nc(-c2ccccc2)n1>>Clc1cccc2c1c1ccccc1n2-c1nc(-c2ccccc2)nc(-c2ccccc2)n1,,CN(C)C=O,O,CO,[H-].[Na+],val
US20060083947A1,Brc1ccccc1I.OB(O)c1ccc(-c2ccccc2)cc1>>Brc1ccc(-c2ccccc2-c2ccccc2)cc1,,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20160096827A1,C=O.Cc1cc(Nc2ncnc(-c3ccc(O[C@H]4CCN(C=O)CC4(F)F)c(C#N)c3)n2)ccc1C1CCNCC1>>Cc1cc(Nc2ncnc(-c3ccc(O[C@H]4CCN(C=O)CC4(F)F)c(C#N)c3)n2)ccc1C1CCN(C)CC1,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20020103229A1,CC(=O)n1nc(-c2ccc(F)cc2)c2cc(C(=O)Cl)ccc21.NCc1ccccn1>>O=C(NCc1ccccn1)c1ccc2[nH]nc(-c3ccc(F)cc3)c2c1,,c1ccncc1,,,,val
US20110046127A1,NCc1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12.O=C(Cl)c1ccccc1>>O=C(NCc1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12)c1ccccc1,,c1ccncc1,,,,val
US06599917B1,C#CC1(O)CN2CCC1CC2.COCCOc1ccc(Br)c(Cc2ccccc2)n1>>COCCOc1ccc(C#CC2(O)CN3CCC2CC3)c(Cc2ccccc2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,CCN(CC)CC,,val
US20080027059A1,CN(C)c1ccc(C(=O)O)cc1.NCc1ccc(C2=NOC(O)(C(F)(F)F)C2)cc1>>CN(C)c1ccc(C(=O)NCc2ccc(C3=NOC(O)(C(F)(F)F)C3)cc2)cc1,CN(C)c1ccncc1,CN(C)C=O,ClCCl,CCN=C=NCCCN(C)C,Cl,val
US04071625,CC(=O)O[C@H]1C[C@@H](C)[C@@]2(CO)[C@@H](CC[C@H]3[C@@H]4CC[C@H](OC(C)=O)[C@@]4(C)CC[C@@H]32)C1.O=S(=O)(O)O.O=[Cr](=O)=O>>CC(=O)O.CC(=O)O.C[C@@H]1C[C@H](O)C[C@@H]2CC[C@H]3[C@@H]4CC[C@H](O)[C@@]4(C)CC[C@@H]3[C@@]12C=O,,CC(C)=O,,,,val
US20120252758A1,C[Si](C)(C)C#N.[O-][n+]1cccc(Br)c1Cl>>N#Cc1ccc(Br)c(Cl)n1,,CC#N,,CCN(CC)CC,,val
US03987040,CO.O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)O)C(CBr)=CS[C@H]12>>COCC1=CS[C@@H]2C(NC(=O)Cc3cccs3)C(=O)N2C1C(=O)O,,CO,ClC(Cl)Cl,CCOC(C)=O,O=C([O-])O.[Na+],val
US20100298293A1,CC(C)(C)[Si](OCCN1CCCN(c2ccc(N3C[C@H](CNC(=O)c4ccc(Cl)s4)OC3=O)cc2C(F)(F)F)C1=O)(c1ccccc1)c1ccccc1>>O=C(NC[C@H]1CN(c2ccc(N3CCCN(CCO)C3=O)c(C(F)(F)F)c2)C(=O)O1)c1ccc(Cl)s1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(CC)c(OC)cc1CC2CC>>CCc1cc2c(cc1OC)CC(CC)n1cc(C(=O)O)c(=O)cc1-2,,C1CCOC1,,Cl,[Na+].[OH-],val
US20160272634A1,CC(C)(C)OC(=O)C(C)(C)N.O=S(=O)(Cl)c1ccc(Br)cc1>>CC(C)(C)OC(=O)C(C)(C)NS(=O)(=O)c1ccc(Br)cc1,,ClCCl,,CCN(CC)CC,,val
US20150018422A1,CCOC(=O)CC(c1cc(CO)ncn1)C1CC1.COc1ccc(F)c(-c2ncc(O)cc2CC(C)(C)C)c1>>CCOC(=O)CC(c1cc(COc2cnc(-c3cc(OC)ccc3F)c(CC(C)(C)C)c2)ncn1)C1CC1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20090105344A1,CC(C)CC(C(=O)N1C(=O)OCC1Cc1ccccc1)c1cc(O)cc(-c2ccc(C(F)(F)F)cc2)c1.Fc1cc(F)cc(CBr)c1>>CC(C)CC(C(=O)N1C(=O)OCC1Cc1ccccc1)c1cc(OCc2cc(F)cc(F)c2)cc(-c2ccc(C(F)(F)F)cc2)c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060211730A1,CS(=O)(=O)Cl.Cc1cc(COc2ccc(S(=O)(=O)N[C@H]3CNC[C@H]3C(=O)OC(C)(C)C)cc2)c2ccccc2n1>>Cc1cc(COc2ccc(S(=O)(=O)N[C@H]3CN(S(C)(=O)=O)C[C@H]3C(=O)OC(C)(C)C)cc2)c2ccccc2n1,,CCN(C(C)C)C(C)C,CN(C)C=O,Cl,,val
US20160166560A1,COc1cccc(CN2CCC(N(C)C(=O)n3cnc(-c4cccc(N)c4)c3)CC2)c1.NS(=O)(=O)Cl>>COc1cccc(CN2CCC(N(C)C(=O)n3cnc(-c4cccc(NS(N)(=O)=O)c4)c3)CC2)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020115674A1,CC(C)(C)ON.O=C(O)c1cc(F)c(N2CCCC2)c(F)c1NC1CC1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)On1c(=O)c2cc(F)c(N3CCCC3)c(F)c2n(C2CC2)c1=O,,C1CCOC1,O,CCN(CC)CC,Cl,val
US20050090533A1,CC(C)(C)[Si](C)(C)O[C@H]1CNC[C@H](O[Si](C)(C)C(C)(C)C)C1.O=C(Cl)OCc1ccccc1>>CC(C)(C)[Si](C)(C)O[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN(C(=O)OCc2ccccc2)C1,,C1CCOC1,,CCN(CC)CC,,val
US20140088075A1,CCn1c(=O)c(-c2cc(NC(=O)Nc3ccc(F)c(CN4CCOCC4)c3)c(F)cc2Cl)cc2cnc(NC=O)cc21.Cl>>CCn1c(=O)c(-c2cc(NC(=O)Nc3ccc(F)c(CN4CCOCC4)c3)c(F)cc2Cl)cc2cnc(NC=O)cc21.Cl,,CC#N,,,,val
US20110098429A1,C=C(c1cccc(-c2ccccn2)c1)c1cccc(C(C)(C)C)c1OCc1ccccc1>>CC(c1cccc(-c2ccccn2)c1)c1cccc(C(C)(C)C)c1O,[Pd],CCOC(C)=O,CO,,,val
US20160244485A1,C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)[C@@H](C)O.O=C(NC(Cc1ccccc1)C(=O)O)c1ccc([N+](=O)[O-])cc1>>C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)[C@@H](C)O.O=C(NC(Cc1ccccc1)C(=O)O)c1ccc([N+](=O)[O-])cc1,,CO,,,,val
US20020169192A1,CCCCCCCNCCc1cccc(SC(C)(C)C(=O)OC(C)(C)C)c1.O=C=Nc1ccc(F)cc1F>>CCCCCCCN(CCc1cccc(SC(C)(C)C(=O)OC(C)(C)C)c1)C(=O)Nc1ccc(F)cc1F,,ClCCl,,,,val
US06248755B1,COC=O.O=C(CCc1ccccc1)C1CCN(Cc2ccccc2)CC1>>O=CC(Cc1ccccc1)C(=O)C1CCN(Cc2ccccc2)CC1,,C1CCOC1,,CC(C)(C)O[K],,val
US20030118916A1,CN(C)C=O.CN1CC=C(C=Cc2cccn2C)c2ccccc21.O=S(=O)(O)C(F)(F)F>>CN1CC=C(C=Cc2ccc(C=O)n2C)c2ccccc21.O=S(=O)(O)C(F)(F)F,,CC#N,,O=P(Cl)(Cl)Cl,,val
US20140288088A1,Cc1cc2ncccc2cc1Br.N#C[Cu].O>>Cc1cc2[nH]c(=O)ccc2cc1C#N,,O,,CN1CCCC1=O,,val
US20150194612A1,Cc1cnc(Br)cc1C.Cc1ncccc1B1OC(C)(C)C(C)(C)O1>>Cc1cnc(-c2cccnc2C)cc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20160052930A1,IC1COC1.O=[N+]([O-])c1cn[nH]c1>>O=[N+]([O-])c1cnn(C2COC2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080234237A1,COC(=O)/C=C/c1ccccc1NC1CCN(C)CC1>>COC(=O)CCc1ccccc1NC1CCN(C)CC1,[Pd],CCOC(C)=O,CO,[H][H],,val
US05817599,CCCCCCCCCCCCCCCCCCCCC(=S)Cl.NCCN1CCOCC1>>CCCCCCCCCCCCCCCCCCCCC(=S)NCCN1CCOCC1,,c1ccccc1,,CC(=O)N(C)C,,val
US20050261496A1,CC(=O)OC(C)=O.NC(=O)c1[nH]c2ccc(N)cc2c1S(=O)(=O)N1CCOCC1>>CC(=O)Nc1ccc2[nH]c(C(N)=O)c(S(=O)(=O)N3CCOCC3)c2c1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20090275578A1,COC(=O)c1ccccc1CBr.NCCCc1cccc(OC(F)(F)F)c1>>O=C1c2ccccc2CN1CCCc1cccc(OC(F)(F)F)c1,,CCCCCC,Cc1ccccc1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US05668147,CC(C)(C)OC(=O)NC[C@@H]1CNC[C@H]1C(F)(F)F>>NC[C@@H]1CNC[C@H]1C(F)(F)F,,ClCCl,,Cl,O=C(O)C(F)(F)F,val
US20060211724A1,CC(C)(C)C(=O)O.O=C1c2c(c(O)c3nccnc3c2O)C(=O)N1Cc1ccc(Cl)c(Cl)c1>>CC(C)(C)C(=O)Oc1c2c(c(O)c3nccnc13)C(=O)N(Cc1ccc(Cl)c(Cl)c1)C2=O,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20130252944A1,COc1ccc(Cn2cc3c(n2)C(Cl)(C(F)(F)F)CCc2sc(NC(=O)OC(C)(C)C)nc2-3)cc1>>COc1ccc(Cn2cc3c(n2)C(C(F)(F)F)CCc2sc(NC(=O)OC(C)(C)C)nc2-3)cc1,,C1CCOC1,,O,[BH4-].[Li+],val
US05958944,CC(C)(C)OC(=O)NCc1ccc(C(=O)Nc2ccncc2)c(O)c1.CCBr>>CCOc1cc(CNC(=O)OC(C)(C)C)ccc1C(=O)Nc1ccncc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150057271A1,COC(=O)c1ccccc1N1CCOc2cc(S(=O)(=O)N(Cc3ccc(OC)cc3)c3nccs3)ccc21>>COC(=O)c1ccccc1N1CCOc2cc(S(=O)(=O)Nc3nccs3)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130237525A1,C=C1CC(c2c(OC)cccc2OC)N(Cc2ccc(OC(F)(F)F)cc2)C1=O>>COc1cccc(OC)c1C1CC(C)C(=O)N1Cc1ccc(OC(F)(F)F)cc1,,CO,,,,val
US20160194302A1,CCN(CC)C1CCNCC1.CCOC(=O)Cn1ccnc1CCC(=O)O>>CCOC(=O)Cn1ccnc1CCC(=O)N1CCC(N(CC)CC)CC1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040142850A1,CCOC(=O)N(c1ccc(Cl)cc1Cl)c1c(N)cc(N)cc1C(F)(F)F>>Nc1cc(C(F)(F)F)c2c(c1)[nH]c(=O)n2-c1ccc(Cl)cc1Cl,,CCO,,[H-].[Na+],,val
US20040053958A1,CC(C)c1nnc2ccc(-c3ocnc3-c3cc(F)ccc3F)cn12.CS(=O)(=O)O>>CC(C)c1nnc2ccc(-c3ocnc3-c3cc(F)ccc3F)cn12.CS(=O)(=O)O,,CC(C)O,,,,val
US20060079541A1,Cc1ncc2ccccc2c1C#N.O=C1CCC(=O)N1Br>>N#Cc1c(CBr)ncc2ccccc12,,ClC(Cl)(Cl)Cl,,,,val
US20070197512A1,CC1(C)Oc2ccccc2NC1=O.COC(=O)CBr>>COC(=O)CN1C(=O)C(C)(C)Oc2ccccc21,,CN(C)C=O,O,Cl,[H-].[Na+],val
US04511574,CCOC(=O)Cl.Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1>>CCOC(=O)Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1,,C1CCOC1,,CCN(CC)CC,,val
US20110015156A1,O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1CO.O=C=NCc1ccccc1>>O=C(NCc1ccccc1)OCN1C(=O)CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc21,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20020086879A1,CC(C)(C)OC(=O)N1CC[C@H](CN)[C@H](O)C1.Nc1c(Cl)cc(C(=O)n2ccnc2)c2c1CCO2>>CC(C)(C)OC(=O)N1CC[C@H](CNC(=O)c2cc(Cl)c(N)c3c2OCC3)[C@H](O)C1,,CC#N,,,,val
US05480905,ClCC1COc2ccccc2O1.O=C1NC(=O)c2ccccc21>>NCC1COc2ccccc2O1,,CN(C)C=O,,[K],,val
US20140200225A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)N1CCN(C(=O)c2cc(O)cc(Oc3ccc(CN)cc3)c2)CC1>>CCOC(=O)N1CCN(C(=O)c2cc(O)cc(Oc3ccc(CNC(=O)OC(C)(C)C)cc3)c2)CC1,,C1COCCO1,O,,,val
US20130345123A1,CCOC(=O)/C=C/C[C@@H](C)NC(=O)OC(C)(C)C>>CCOC(=O)CCC[C@@H](C)NC(=O)OC(C)(C)C,[Pd],CCO,,[H][H],,val
US20120316165A1,CCOC(=O)c1cnn(-c2cncc(C(F)(F)F)n2)c1>>O=C(O)c1cnn(-c2cncc(C(F)(F)F)n2)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100120882A1,CI.COCOc1cc(F)cc(F)c1F>>COCOc1c(C)c(F)cc(F)c1F,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4c(Br)cccc4nn23)CC1.OB(O)c1ccccc1OC(F)(F)F>>CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4c(-c5ccccc5OC(F)(F)F)cccc4nn23)CC1,,C1CCOC1,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20060089359A1,CC(=O)Nc1ccc(-n2nc(Br)c3ccccc3c2=O)cc1.CCI>>CCN(C(C)=O)c1ccc(-n2nc(Br)c3ccccc3c2=O)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20080019915A1,COC(=O)c1ccc(C)c(B2OC(C)(C)C(C)(C)O2)c1C.Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1Cl>>COC(=O)c1ccc(C)c(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)ccc2C)c1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20100216746A1,CC(C)(C)[Si](C)(C)OCCBr.CCOC(=O)c1cc2cc(O)ccc2n1C(=O)OC(C)(C)C>>CCOC(=O)c1cc2cc(OCCO[Si](C)(C)C(C)(C)C)ccc2n1C(=O)OC(C)(C)C,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20160067691A1,O=C(C1CCCCC1)N1CCCCC1>>C1CCC(CN2CCCCC2)CC1,,ClCCl,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100249139A1,COC(=O)c1ccc(Oc2ccc(Cl)c(C(C)C(O)(c3ccnc(Cl)c3)C(F)(F)F)c2)nc1>>CC(c1cc(Oc2ccc(C(=O)O)cn2)ccc1Cl)C(O)(c1ccnc(Cl)c1)C(F)(F)F,,C1CCOC1,,O,[Li+].[OH-],val
US20070244095A1,COC(=O)CCCBr.COC(=O)c1cc(Br)ccc1NC(=O)OC(C)C>>COC(=O)CCCN(C(=O)OC(C)C)c1ccc(Br)cc1C(=O)OC,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20100204265A1,COC(=O)c1cn2cccc(C(F)(F)F)c2n1>>O=C(O)c1cn2cccc(C(F)(F)F)c2n1,,C1CCOC1,O,[Na+].[OH-],,val
US20080125468A1,CCCCCC[Mg]Br.CON(C)C(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)c(C)c1>>CCCCCCC(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)c(C)c1,,C1CCOC1,CCOC(C)=O,O,[Cl-].[Na+],val
US20140249130A1,O=[N+]([O-])c1cc(Br)nc(Nc2cc(C(F)(F)F)ccn2)c1>>Nc1cc(Br)nc(Nc2cc(C(F)(F)F)ccn2)c1,[Fe],CC(=O)O,,,,val
US20050176645A1,CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)OC(C)(C)C)C(=O)O.COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314>>CC(C)C[C@H](NC(=O)CNC(=O)CN)C(=O)O.COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314,,C1COCCO1,,Cl,,val
US03959309,CCOC(=O)CBr.COc1cc2[nH]c3c(c2cc1OC)CC(OC(=O)c1ccccc1)CC3>>CCOC(=O)Cn1c2c(c3cc(OC)c(OC)cc31)CC(OC(=O)c1ccccc1)CC2,,CN(C)C=O,,[H-].[Na+],,val
US20130253194A1,Brc1cnn2ccc(N3CCNCC3)nc12.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCN(c2ccn3ncc(Br)c3n2)CC1,,CCOC(C)=O,,,,val
US20080139639A1,CC(=O)c1ccccc1F.CCOC(=O)CC#N>>CCOC(=O)C(C#N)CC(=O)c1ccccc1F,Br[Cu]Br,CC(C)=O,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US05342833,C#CC(C)(C)O[Si](C)(C)C(C)(C)C.CN(C)C=O>>CC(C)(C#CC=O)O[Si](C)(C)C(C)(C)C,,CCCCCC,,C1CCOC1,,val
US20140296260A1,CC[C@H](N)c1nc2cccc(F)c2c(=O)n1-c1ccccc1.Clc1ccnc2[nH]ccc12>>CC[C@H](Nc1ccnc2[nH]ccc12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1,,CC(C)(C)O,,CCN(C(C)C)C(C)C,,val
US20060160857A1,C#C[Si](C)(C)C.[N-]=[N+]=Nc1cccc([N+](=O)[O-])c1>>C[Si](C)(C)c1cn(-c2cccc([N+](=O)[O-])c2)nn1,,C1CCOC1,,,,val
US06369273B1,Nc1ccc(I)cc1F.Sc1ccccc1>>Nc1ccc(Sc2ccccc2)cc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,C[O-].[Na+],,val
US04820705,O=C1CCC(=O)O1.O=S(=O)(NC1Cc2ccccc2C1)c1ccc(Cl)cc1>>O=C(O)CCC(=O)c1ccc2c(c1)CC(NS(=O)(=O)c1ccc(Cl)cc1)C2,,ClCCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20080176813A1,O=C1C=C[C@H](CC(=O)c2ccccc2)[C@H](C(=O)c2ccccc2)C1>>O=C(C[C@H]1C=C[C@@H](O)C[C@H]1C(=O)c1ccccc1)c1ccccc1,,CO,,[BH4-].[Na+],,val
US20070093521A1,CCOC(=O)C1(Oc2ccc3oc(NC4CCN(Cc5cc(OCC)c(F)c(OCC)c5)CC4)nc3c2)CCC1.CCOc1cc(C=O)cc(OCC)c1-n1cccc1>>CCOC(=O)C1(Oc2ccc3oc(NC4CCN(Cc5cc(OCC)c(-n6cccc6)c(OCC)c5)CC4)nc3c2)CCC1,,CC(=O)O,CCO,CCN(C(C)C)C(C)C,[BH3-]C#N.[Na+],val
US20120028959A1,CC(=O)Nc1c(C(C)=O)cccc1[N+](=O)[O-]>>CC(=O)c1cccc([N+](=O)[O-])c1N,,CCO,,Cl,,val
US20150087600A1,COC(=O)N1CCNCC1C(=O)O>>COC(=O)N1CCNC[C@H]1C(=O)O,[Pd],CO,,Cl,,val
US20100267780A1,Cc1ccc(C(=O)O)cc1Br.[NH4+]>>Cc1ccc(C(N)=O)cc1Br,,O=S(Cl)Cl,,CCN(CC)CC,,val
US05304560,NC(=O)c1c(F)cccc1NCCCCN1CC=C(c2ccccc2)CC1.O=C(Cl)OC(Cl)(Cl)Cl>>Cl.O=c1[nH]c(=O)n(CCCCN2CC=C(c3ccccc3)CC2)c2cccc(F)c12,,C1COCCO1,,C,,val
US20080176846A1,CO.Cc1ccc(NC(=O)c2ccccc2)cc1-c1cc2cnc(Cl)cc2n(C)c1=O>>COc1cc2c(cn1)cc(-c1cc(NC(=O)c3ccccc3)ccc1C)c(=O)n2C,,CO,,C[O-].[Na+],,val
US04122083,BrCc1ccccc1.c1ccc2c(c1)nc1sc3c(n12)CCNC3>>c1ccc(CN2CCc3c(sc4nc5ccccc5n34)C2)cc1,,CCOC(C)=O,,CCN(CC)CC,Cc1ccccc1,val
US20120184525A1,CC1(c2ccccn2)C(C#N)C(=O)NC(=O)C1C#N.CO.[OH-]>>CC(CC(=O)O)(CC(=O)O)c1ccccn1,,O,,O=S(=O)(O)O,,val
US20110059951A1,CC(O)CN1CCN(C(=O)OCc2ccccc2)CC1.CS(=O)(=O)Cl>>CC(CN1CCN(C(=O)OCc2ccccc2)CC1)OS(C)(=O)=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100285145A1,CC(C)(C)[Si](C)(C)Cl.OCCSc1ccc2c(c1)CCN2>>CC(C)(C)[Si](C)(C)OCCSc1ccc2c(c1)CCN2,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20110098296A1,BrCc1ccccc1.CCOC(=O)c1cccc(O)c1>>CCOC(=O)c1cccc(OCc2ccccc2)c1,,CCOCC,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05478856,CCOC(=O)CC#N.COc1cc(C=O)cc(OC)c1O>>COc1cc(C=C(C#N)C(=O)O)cc(OC)c1O,,CCO,,C1CCNCC1,,val
US20080293775A1,CN(C)C(=O)Sc1cc(CC(=O)O)cc(C(F)(F)F)c1>>O=C(O)Cc1cc(S)cc(C(F)(F)F)c1,,CO,Cl,[Na+].[OH-],,val
US20140228349A1,CC(C)(C)[Si](C)(C)OCC(OS(C)(=O)=O)C1CC1.Cn1cc(-c2cc3nccn3c(-c3cn[nH]c3)n2)cn1>>Cn1cc(-c2cc3nccn3c(-c3cnn(C(CO[Si](C)(C)C(C)(C)C)C4CC4)c3)n2)cn1,,CN(C)C=O,,[H-].[Na+],,val
US04808729,BrCCCOc1ccccc1.CCOC(=O)CCC1(CCC(=O)OCC)OCC(CS)S1>>CCOC(=O)CCC1(CCC(=O)OCC)OCC(CSCCCOc2ccccc2)S1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110297881A1,CCC[C@@H]1CC[C@@H](C(=O)CC(=O)OCC)CC1>>CCC[C@@H]1CC[C@@H](C(O)CCO)CC1,,CCO,,[BH4-].[Na+],,val
US20130059858A1,Fc1cccc2c1OC(C1CCNCC1)C2.O=C1CCC(=O)N1Br>>Fc1cc(Br)cc2c1OC(C1CCNCC1)C2,,CO,ClCCl,Cl,,val
US20140323468A1,CC(C)(C)OC(=O)N1CCCc2cc(-c3cncc(OCCN4CCOC4=O)c3)cnc21>>O=C1OCCN1CCOc1cncc(-c2cnc3c(c2)CCCN3)c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US05872115,CCCCN=C=O.CCN(CC)c1ccc(N)c(C(=O)NCC2CCN(C(c3ccccc3)c3ccccc3)CC2)c1>>CCCCNC(=O)Nc1ccc(N(CC)CC)cc1C(=O)NCC1CCN(C(c2ccccc2)c2ccccc2)CC1,,ClC(Cl)Cl,,,,val
US20160130229A1,CCOC(=O)CC#N.O=Cc1cccs1>>CCOC(=O)/C(C#N)=C/c1cccs1,C1CCNCC1,CCO,,,,val
US20070027318A1,COc1cc2ncnc(Oc3ccc(N)c(F)c3)c2cc1OC.Cc1ccccc1N=C=O>>COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccccc4C)c(F)c3)c2cc1OC,,ClC(Cl)Cl,,CO,,val
US20050176789A1,COc1ccccc1C(=O)CBr.NC(N)=S>>COc1ccccc1-c1csc(N)n1,,CCO,,,,val
US20050054536A1,CCCOC(=O)C(C#N)=C(O)C(CC)CSC.CCN(CC)CC>>CCCOC(=O)/C(C#N)=C(\N)C(CC)CSC,,ClCCl,,O=P(Cl)(Cl)Cl,,val
US03974150,CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC=O)[C@H]2SC1.[N-]=[N+]=C(c1ccccc1)c1ccccc1>>CC(=O)OCC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](NC=O)[C@H]2SC1,,C1CCOC1,CCOCC,,,val
US04623659,COc1c(C#N)c(OC)c(OC)c(OC)c1OC>>N#Cc1c(O)c(O)c(O)c(O)c1O,,Cc1ccccc1,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20050054670A1,CC(C)(C)c1ccc(N2Cc3cccc(O)c3C2=O)cc1.OCc1ccncc1>>CC(C)(C)c1ccc(N2Cc3cccc(OCc4ccncc4)c3C2=O)cc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150196566A1,CS(=O)c1nc2ccc(CN3C=CN=C(N4CCOCC4)C3)cc2s1.N[C@@H]1CCCC[C@H]1O>>O[C@@H]1CCCC[C@H]1Nc1nc2ccc(CN3C=CN=C(N4CCOCC4)C3)cc2s1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,O,val
US06166006,CCOC(=O)C1=Cc2cc(-c3ccc(SC)cc3)ccc2OCC1>>CSc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCO3)cc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20040209865A1,CC1CCNCC1.OCc1cc2cc(C#Cc3ccc(-c4ccc(Cl)cc4)cn3)ccc2o1>>CC1CCN(Cc2cc3cc(C#Cc4ccc(-c5ccc(Cl)cc5)cn4)ccc3o2)CC1,,ClCCl,O,CCN(CC)CC,CS(=O)(=O)Cl,val
US20080139614A1,CC(C)(C)OC(=O)N1CCC(Oc2ncc(-c3ccc(C#N)cc3)cn2)CC1>>N#Cc1ccc(-c2cnc(OC3CCNCC3)nc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040063780A1,CSCc1ccoc1C=O>>CSCc1ccoc1CO,,CO,,[BH4-].[Na+],,val
US20140200205A1,C=CCCC[C@H](NC(=O)[C@H]1CCCC(=O)N1)C(=O)Nc1ccccc1.CC(O)=S>>CC(=O)SCCCCC[C@H](NC(=O)[C@H]1CCCC(=O)N1)C(=O)Nc1ccccc1,,C1COCCO1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20140088085A1,CCCN(CCC)C(=O)C1=Cc2ccc(-c3ccc(C(=O)N4CCCC4)cc3)cc2N=C(NC(=O)OC(C)(C)C)C1.NN>>CCCN(CCC)C(=O)C1=Cc2ccc(-c3ccc(C(=O)N4CCCC4)cc3)cc2N=C(NN)C1,,CCO,CCOC(C)=O,,,val
US04282242,COC(=O)c1c[nH]c(C(=O)c2ccc(Cl)cc2Cl)c1>>O=C(O)c1c[nH]c(C(=O)c2ccc(Cl)cc2Cl)c1,,CO,,[Na+].[OH-],,val
US04166854,CC(C)(C)C(=O)C(Br)Oc1cccc(F)n1.c1c[nH]cn1>>CC(C)(C)C(=O)C(Oc1cccc(F)n1)n1ccnc1,,CC(C)=O,,C1CCC2=NCCCN2CC1,,val
US20080139551A1,CCOC(=O)c1c(Cl)c2cc(C)ccc2n(-c2ccccc2)c1=O.O=CN1CCNCC1>>CCOC(=O)c1c(N2CCN(C=O)CC2)c2cc(C)ccc2n(-c2ccccc2)c1=O,,ClCCl,,O,,val
US20120142717A1,N#CN.O=S(=O)(O)C(F)(F)F.OCCc1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)c(F)c1>>N=C(N)OCCc1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)c(F)c1.O=S(=O)(O)C(F)(F)F,,C1CCOC1,,,,val
US05021413,C1CCN(CC2CSCCN2)CC1.O=C1CC(C(=O)Cl)c2cc(Cl)c(Cl)cc21>>Cl.O=C1CC(C(=O)N2CCSCC2CN2CCCCC2)c2cc(Cl)c(Cl)cc21,,CCN(CC)CC,,,,val
US20070219211A1,Nc1cc(Cl)ccc1[N+](=O)[O-].O=C(c1ccccc1C(F)(F)F)N1CCNCC1>>Nc1cc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)ccc1[N+](=O)[O-],,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140349990A1,COc1ncc(-n2nc(C(=O)O)c(C(Nc3cc(C)c(=O)n(C)c3)c3ccc(Cl)cc3)c2C)c(OC)n1>>COc1ncc(-n2nc3c(c2C)C(c2ccc(Cl)cc2)N(c2cc(C)c(=O)n(C)c2)C3=O)c(OC)n1,,CO,ClCCl,,,val
US20070185140A1,Clc1nc(-n2cnc3ccccc32)c2nc[nH]c2n1.OCCNCCO>>OCCN(CCO)c1nc(-n2cnc3ccccc32)c2nc[nH]c2n1,,CS(C)=O,,,,val
US20070185101A1,CC(=O)N1CCC(O)CC1.ClCc1ccc(Cl)cc1>>CC(=O)N1CCC(OCc2ccc(Cl)cc2)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US20080021010A1,CC(C)(C)OC(=O)N1CC(C#N)(c2ccccn2)C1.COS(=O)(=O)C(F)(F)F>>CN1CCCCC1C1(C#N)CN(C(=O)OC(C)(C)C)C1,O=[Pt]=O,ClCCCl,,CC(=O)O,,val
US20030220347A1,CC(Br)COc1ccc(C#CCCO)cc1.Clc1ccc([C@@H](c2ccccc2)N2CCNCC2)cc1>>OCCC#Cc1ccc(OCCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1,,ClCCl,,CCN(CC)CC,,val
US05693379,CC[C@@H]1CC[C@@H](c2ccc(O)cc2)CC1.OCCCBr>>CCC(O)Oc1ccc([C@@H]2CC[C@@H](CC)CC2)cc1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20140194411A1,CCOC(=O)N1CCc2ccc3c(c2CC1)C(C)(Cl)C(F)(F)C3.C[Al](C)C>>CCOC(=O)N1CCc2ccc3c(c2CC1)C(C)(C)C(F)(F)C3,,C1CCCCC1,,,,val
US05220000,N#CC(C#N)=Cc1ccc([N+](=O)[O-])cc1>>N#CC(C#N)Cc1ccccc1,,CCOC(C)=O,O,CCO,[BH4-].[Na+],val
US06043242,CSc1ccc2nc(S)[nH]c2c1.Cc1c(SCCCSc2ccc3ncc([N+](=O)[O-])n3n2)ccnc1CCl>>CSc1ccc2[nH]c(SCc3nccc(SCCCSc4ccc5ncc([N+](=O)[O-])n5n4)c3C)nc2c1.Cl,,CC(C)O,,,,val
US20100286390A1,CCOC(=O)CCCn1ncc(N[C@@H]2C[C@@H]3C[C@H]([C@H]2C)C3(C)C)c(Br)c1=O>>C[C@H]1[C@H](Nc2cnn(CCCC(=O)O)c(=O)c2Br)C[C@@H]2C[C@H]1C2(C)C,,C1COCCO1,,CCOC(C)=O,[Na+].[OH-],val
US07998972B2,O=[N+]([O-])c1cnc2cc(Cl)ccc2c1Nc1ccc(F)cc1>>Nc1cnc2cc(Cl)ccc2c1Nc1ccc(F)cc1,[Ni],C1CCOC1,CO,,,val
US20090197909A1,COc1ccc(C2c3cncn3CCC2(C)C)cc1>>CC1(C)CCn2cncc2C1c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US05709867,C=CCOC(=O)c1ccc(N)cc1.COC(=O)C(C(=O)Cl)c1ccc2c(c1)C(C)(C)CCC2(C)C>>C=CCOC(=O)c1ccc(NC(=O)C(C(=O)OC)c2ccc3c(c2)C(C)(C)CCC3(C)C)cc1,,O,,C1CCOC1,CCN(CC)CC,val
US20150218096A1,COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C#CCO)ccc23)cc1>>O=C(O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C#CCO)ccc23)cc1,,C1CCOC1,O,Cl,[Li]O,val
US20110092479A1,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc([C@@H]4CC4(F)F)c3c2)c1F.Cc1ccc(S(=O)(=O)n2nc(O)cc2N)cc1.O=CC(C=O)[N+](=O)[O-]>>Cc1ccc(S(=O)(=O)n2nc(O)c3cc([N+](=O)[O-])cnc32)cc1,,CC(=O)O,O,[Na],,val
US04637902,O=C(O)c1cc(Br)ccc1O.Oc1ccccc1>>O=C(Oc1ccccc1)c1cc(Br)ccc1O,,c1ccccc1,,O=S(Cl)Cl,,val
US09085570B2,CN1CCNCC1.Cc1oc(-c2ccc(C(=O)NCc3cccnc3)cc2)nc1CS(=O)(=O)c1ccc(F)cc1>>Cc1oc(-c2ccc(C(=O)NCc3cccnc3)cc2)nc1CS(=O)(=O)c1ccc(N2CCN(C)CC2)cc1,,CS(C)=O,,,,val
US20110281842A1,COCOC1(c2ncc(-c3c(Cl)cnc4c3cc(C3=CCN(C(=O)OC(C)(C)C)CC3)n4S(=O)(=O)c3ccc(C)cc3)s2)CCC1>>Cc1ccc(S(=O)(=O)n2c(C3=CCNCC3)cc3c(-c4cnc(C5(O)CCC5)s4)c(Cl)cnc32)cc1,,C1CCOC1,CO,Cl,,val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nc(C(F)(F)C(F)(F)C(N)=O)n[nH]3)cc2)cc1.Cl>>Cc1cc(C(=O)NC2CCNCC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc(-c3nc(C(F)(F)C(F)(F)C(N)=O)n[nH]3)cc2)cc1.Cl,,C1COCCO1,,CC#N,,val
US04975444,CC(C)(C)OC(=O)NCCCC[C@H](N)C(=O)NC[C@H](CC1(C(=O)N[C@@H](Cc2ccc(OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CCCC1)C(=O)OC(C)(C)C.CC=O>>CCN[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)NC[C@H](CC1(C(=O)N[C@@H](Cc2ccc(OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CCCC1)C(=O)OC(C)(C)C,,CCO,,Cl,[BH3-]C#N.[Na+],val
US20040023947A1,CCOC(=O)C1NCCc2c1[nH]c1ccccc21.O=C(Cl)c1ccc(F)cc1>>CCOC(=O)C1c2[nH]c3ccccc3c2CCN1C(=O)c1ccc(F)cc1,CN(C)c1ccncc1,ClCCCl,,CCN(C(C)C)C(C)C,,val
US20160052884A1,O=[N+]([O-])c1ccc(-c2cnc(C(F)(F)F)[nH]2)cc1>>Nc1ccc(-c2cnc(C(F)(F)F)[nH]2)cc1,[Pd],CCO,,,,val
US04871852,CN1CCNCC1.O=C(O)c1cn(C2CC2F)c2c(F)c(F)c(F)cc2c1=O>>CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4F)c3c2F)CC1,,CS(C)=O,,,,val
US04767867,CI.CN1OC(CO)CC1(Cn1ccnc1)c1ccc(Cl)cc1>>COCC1CC(Cn2ccnc2)(c2ccc(Cl)cc2)N(C)O1,,C1CCOC1,,O,[H-].[Na+],val
US20100016319A1,COc1cc(Cl)nc(OC)n1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2O)cc1>>COc1cc(Oc2ccccc2CNC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(C)cc2)nc(OC)n1,,CC(C)=O,,[Na+].[OH-],[Cl-].[NH4+],val
US20160096835A1,CCN(c1cccnc1)S(=O)(=O)c1ccc(Cl)nc1.NN>>CCN(c1cccnc1)S(=O)(=O)c1ccc(NN)nc1,,CCO,,O,,val
US20080207654A1,CCCc1nc(C)n(-c2ccc(CC(C)C)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCc1nc(C)n(-c2ccc(CC(C)C)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20090227640A1,Br.COc1ccc(CCc2ccc(F)cc2CO)cc1.c1ccc([PH+](c2ccccc2)c2ccccc2)cc1>>COc1ccc(CCc2ccc(F)cc2C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1.[Br-],,CC#N,,,,val
US20110118251A1,CCOC(=O)c1n[nH]cc1CN1CCC2(CC1)OCC(F)(F)c1cc(Cl)sc12.Fc1cccnc1F>>CCOC(=O)c1nn(-c2ncccc2F)cc1CN1CCC2(CC1)OCC(F)(F)c1cc(Cl)sc12,,CN(C)C=O,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20160022673A1,Cc1ccc(C2=NOC(C)(C(=O)O)C2)cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1.NC1CC1>>Cc1ccc(C2=NOC(C)(C(=O)NC3CC3)C2)cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1,,CC#N,,CCN(CC)CC,O=S(Cl)Cl,val
US20090105275A1,CCOC(=O)C(CC(C)C)c1cc(-c2ccc(C(F)(F)F)cc2)cc(N2CCCCC2CC)c1>>CCC1CCCCN1c1cc(-c2ccc(C(F)(F)F)cc2)cc(C(CC(C)C)C(=O)O)c1,,CO,,[Na+].[OH-],,val
US20040082571A1,Cc1n[nH]c(C)c1Br.O=C(CCl)N1CCN(c2ccc(F)cc2)CC1>>Cc1nn(CC(=O)N2CCN(c3ccc(F)cc3)CC2)c(C)c1Br,,CCCCCC,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070072905A1,COc1cc2c(cc1OC)C(=O)C(Cc1ccncc1)C2.Cc1ccc(S(=O)(=O)O)cc1>>COc1cc2c(cc1OC)C(=O)C(CC1CCNCC1)C2.Cc1ccc(S(=O)(=O)O)cc1,O=[Pt]=O,CO,,,,val
US06919404B2,CCCNCCC.O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1>>CCCN(CCC)c1ccc([N+](=O)[O-])cc1[N+](=O)[O-],,CN1CCCC1=O,,O,O=C([O-])[O-].[K+].[K+],val
US04957927,O=C(O)COC(c1ccccc1)c1ccccc1.O=S(Cl)Cl>>O=C(Cl)COC(c1ccccc1)c1ccccc1,,c1ccccc1,,,,val
US20120094917A1,COC(=O)C1CN(C(=O)OCc2ccccc2)C2CCN(C(=O)C(NC(=O)OC(C)(C)C)C3CCCCC3)C12>>COC(=O)C1CNC2CCN(C(=O)C(NC(=O)OC(C)(C)C)C3CCCCC3)C21,[Pd],CO,,,,val
US20100305085A1,COC(=O)C(=CN(C)C)c1nnc(C(F)(F)F)s1.NNc1cc(N2CCOCC2)ncn1>>O=c1c(-c2nnc(C(F)(F)F)s2)c[nH]n1-c1cc(N2CCOCC2)ncn1,,CO,,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US20090029903A1,CCCCCC=O.COc1ccc(C#Cc2ccc(CNc3ccc4c(c3)C(=O)OC(C)(C)O4)cc2)cc1>>CCCCCCN(Cc1ccc(C#Cc2ccc(OC)cc2)cc1)c1ccc2c(c1)C(=O)OC(C)(C)O2,,CC(=O)O,ClCCCl,O=C([O-])O.[Na+],,val
US20130210803A1,CC(C)=O.O=NN1CC(c2ccc(F)cc2)Cc2ccccc21>>CC(C)=NN1CC(c2ccc(F)cc2)Cc2ccccc21,[Zn],,,O,[Cl-].[NH4+],val
US20080269280A1,COCCN.Cc1c(Cl)cccc1N1CN(C(=O)CCl)CC1=O>>COCCNCC(=O)N1CC(=O)N(c2cccc(Cl)c2C)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20010031760A1,COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC.O=C(Cl)c1cocn1>>COc1cc2nc(N3CCN(C(=O)c4cocn4)CC3)nc(N)c2cc1OC.Cl,,C1COCCO1,,,,val
US20110269712A1,CCOC(=O)c1csc(N2CCN(C(=O)Cn3nc(C(F)(F)F)cc3C)CC2)n1>>Cc1cc(C(F)(F)F)nn1CC(=O)N1CCN(c2nc(C(=O)O)cs2)CC1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20030013720A1,CNCC1(c2ccc(I)cc2)CCN(C(=O)OC(C)(C)C)CC1.O=C=Nc1cc(Cl)cc(Cl)c1>>CN(CC1(c2ccc(I)cc2)CCN(C(=O)OC(C)(C)C)CC1)C(=O)Nc1cc(Cl)cc(Cl)c1,,ClCCl,,,,val
US06777111B1,Nc1ccccc1.Nc1ccccc1.O=C1C2CC3CC(C2)CC1C3>>c1ccc(NC2C3CC4CC(C3)CC2(Nc2ccccc2)C4)cc1,,O,,Cl,[K+].[OH-],val
US20090181942A1,COC(=O)/C=C/c1cccn1-c1ccc(Cl)cc1C(=O)c1c(F)ccc(OC)c1OC>>COC(=O)/C=C/c1cccn1-c1ccc(Cl)cc1C(O)c1c(F)ccc(OC)c1OC,,CCOC(C)=O,,CO,[BH4-].[Na+],val
US20060160862A1,CC(C)(C)OC(=O)[C@H](Cc1ccccc1)n1cccc(N)c1=O.O=C(Cl)c1ccccc1>>CC(C)(C)OC(=O)[C@H](Cc1ccccc1)n1cccc(NC(=O)c2ccccc2)c1=O,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20050131017A1,CC[C@H](C)[C@@H](C(=O)OC(C)(C)C)N1CC(=O)N(Cc2csc(-c3cccnc3)n2)C1=O>>CC[C@H](C)[C@@H](C(=O)O)N1CC(=O)N(Cc2csc(-c3cccnc3)n2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US05100577,CCCCCCCCCCc1cnc(-c2ccc(OCC3(O)CCCCC3)cc2)nc1.CCCC[C@H](F)C(=O)O>>CCCCCCCCCCc1cnc(-c2ccc(OC[C@@H]3CC[C@@H](OC(=O)[C@@H](F)CCCC)CC3)cc2)nc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100261719A1,C[C@@H]1CN2c3ccc([N+](=O)[O-])cc3CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1>>C[C@@H]1CN2c3ccc(N)cc3CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1,[Ni],C1CCOC1,,[H][H],,val
US20040019063A1,Cc1c(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)ccc(Br)c1Cl.N#C[Cu]C#N>>Cc1c(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)ccc(C#N)c1Cl,,CN(C)C=O,O,,,val
US20130200341A1,COc1ccc(-c2c3c(nc4c2CCc2ccccc2-4)-c2ccccc2CC3)cc1>>COc1ccc(-c2c3ccc4ccccc4c3nc3c2ccc2ccccc23)cc1,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20130210844A1,CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)O)n1.Nc1cccc2c(Oc3cccc(C(F)(F)F)c3)ncnc12>>CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)Nc2cccc3c(Oc4cccc(C(F)(F)F)c4)ncnc23)n1,CN(C)C=O,ClCCl,,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US04919848,CN(C)CCCN.O=C(OC(=O)c1cccc2ccccc12)c1cccc2ccccc12>>CN(C)CCCN=C(O)c1cccc2ccccc12,CC(=O)O,Cc1ccccc1,,O,,val
US20070066618A1,CO.COc1cc([N+](=O)[O-])ccc1CC(=O)O>>COC(=O)Cc1ccc([N+](=O)[O-])cc1OC,,CO,ClCCl,C[Si](C)(C)C=[N+]=[N-],,val
US20080119451A1,C=Cc1cccnc1-c1ccc(C(=O)OC)cc1>>CCc1cccnc1-c1ccc(C(=O)OC)cc1,[Pd],CCO,,,,val
US20140288185A1,CI.CN[C@@]12CCC[C@@H]1[C@H]1CC[C@@H]2C1>>CN(C)[C@@]12CCC[C@@H]1[C@H]1CC[C@@H]2C1.I,,CC#N,,CCOCC,,val
US20020091135A1,O=Cc1ccc([N+](=O)[O-])s1.Oc1ccccc1>>O=Cc1ccc(Oc2ccccc2)s1,,CS(C)=O,,O,[H-].[Na+],val
US20090275578A1,COC(=O)c1c(C)cc(F)cc1C#N.NC(=O)CCC(=O)NBr>>COC(=O)c1c(C#N)cc(F)cc1CBr,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20050124692A1,[N-]=[N+]=NCC1Cc2ccc3c(c2O1)CCCC3>>NCC1Cc2ccc3c(c2O1)CCCC3,[Pd],,,,,val
US20060040957A1,COC(=O)CSc1cc(=O)n(Cc2ccccc2)c(=O)[nH]1.COC(OC)N(C)C>>COC(=O)c1cn2c(=O)n(Cc3ccccc3)c(=O)cc2s1,,C1CCOC1,,C1COCCO1,,val
US20120238574A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.CCOP(=O)(Cc1ccc([N+](=O)[O-])cc1)OCC>>CC(C)(C)OC(=O)N1CCC(=Cc2ccc([N+](=O)[O-])cc2)CC1,,C1CCOC1,,[H-].[Na+],,val
US06486155B1,CC(=O)Cl.COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccccc2c(=O)n1N>>COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccccc2c(=O)n1NC(C)=O,,C1CCOC1,O,CCOC(C)=O,c1ccncc1,val
US20110207701A1,CC1(C)OB(c2cc(-c3cccc(C#N)c3)ccc2C=O)OC1(C)C>>N#Cc1cccc(-c2ccc3c(c2)B(O)OC3)c1,,CO,,[BH4-].[Na+],,val
US04352803,CCOC(=O)c1c[nH]c2nc(N3CCN(C(=O)OCC)CC3)c(F)cc2c1=O.OCCBr>>CCOC(=O)c1cn(CCO)c2nc(N3CCN(C(=O)OCC)CC3)c(F)cc2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06248755B1,Nc1ccccn1.O=C(CBr)C1CCN(C(=O)c2ccccc2)CC1>>O=C(c1ccccc1)N1CCC(c2cn3ccccc3n2)CC1,,CCO,,,,val
US20130261116A1,CNC(=O)c1ccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1F.O[C@@H]1CCNC1>>O[C@@H]1CCN(c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)C1,,CN(C)C=O,,[Cs+].[F-],,val
US05780505,CCCCOc1c(OCCCC)c(=O)c1=O.N#Cc1ccc(CN)c(Cl)c1>>CCCCOc1c(NCc2ccc(C#N)cc2Cl)c(=O)c1=O,,C1CCOC1,,,,val
US05449687,COS(=O)(=O)OC.COc1ccc(C2(C#N)CCC(=O)CC2)cc1OC1CCCC1>>COC1=CCC(C#N)(c2ccc(OC)c(OC3CCCC3)c2)CC1,,CN(C)C=O,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20100093998A1,N.OCc1ccc(Cn2cnc3c(Cl)nc(I)nc32)cc1>>Nc1nc(I)nc2c1ncn2Cc1ccc(CO)cc1,,C1CCOC1,,,,val
US20130296363A1,CCOC(=O)c1cc2ccccc2c(Cl)n1.Fc1ccc([Mg]Br)cc1>>O=C(c1ccc(F)cc1)c1cc2ccccc2c(Cl)n1,,C1CCOC1,,CCOCC,Cl,val
US20070185168A1,O=C1CCc2cc(CCCl)ccc2N1.OC1(c2cccs2)CCNCC1>>O=C1CCc2cc(CCN3CCC(O)(c4cccs4)CC3)ccc2N1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060128734A1,O=[N+]([O-])c1ccc(O)cc1.O=[N+]([O-])c1ccc(Oc2cc(Cl)ncn2)cc1>>O=[N+]([O-])c1ccc(Oc2cc(Nc3ccc(O)cc3)ncn2)cc1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20130184280A1,NC(=S)c1cncnc1N.O=C(CBr)c1cccc([N+](=O)[O-])c1>>Nc1ncncc1-c1nc(-c2cccc([N+](=O)[O-])c2)cs1,,CCO,CN(C)C=O,O=C(O)C(F)(F)F,,val
US05424311,C=C(C)OC(=O)Cl.C[C@@H]1Nc2nc(Cl)ccc2NC1=O>>C=C(C)OC(=O)N1C(=O)[C@H](C)Nc2nc(Cl)ccc21,,c1ccncc1,,,,val
US20080261941A1,Cc1ccc(Oc2cccc(CO)c2)nc1.O=S(Cl)Cl>>Cc1ccc(Oc2cccc(CCl)c2)nc1,,ClCCl,,O=C([O-])O.[Na+],,val
US04126689,CC(C)N1CCC(Nc2ccccc2)CC1.O=C(Cl)Cc1ccccc1>>CC(C)N1CCC(N(C(=O)Cc2ccccc2)c2ccccc2)CC1.Cl,,c1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20140141973A1,CC(=O)c1ccc(Oc2ccc(F)cc2F)cc1Cl.CS(C)=O>>CC1(c2ccc(Oc3ccc(F)cc3F)cc2Cl)CO1,,C1CCOC1,COC(C)(C)C,[H-].[Na+],[Cl-].[NH4+],val
US20070082912A1,COC(=O)c1cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccccc2)ccc1Cl>>Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(Cl)c(C(=O)O)c1,CC(=O)O,CO,O,Cl,[Na+].[OH-],val
US20160136172A1,COc1ncc(Br)cc1C(=O)NCc1ccc(F)cc1>>O=C(NCc1ccc(F)cc1)c1cc(Br)cnc1O,,ClCCl,,BrB(Br)Br,CO,val
US04845118,C=O.COc1ccnc(CSc2nc3cscc3[nH]2)c1>>COc1ccnc(CSc2nc3cscc3n2CO)c1,,CC#N,,,,val
US05202356,CCOC(=O)/C=C/[C@@H]1C[C@@H]1c1cccc(C(F)(F)F)c1>>OC=CC[C@@H]1C[C@@H]1c1cccc(C(F)(F)F)c1,,CCCCCC,,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US20040204586A1,N#Cc1c(N2CCNCC2)c2cc(Cl)ccc2n(Cc2ccccc2)c1=O.O=C(Cl)c1ccco1>>N#Cc1c(N2CCN(C(=O)c3ccco3)CC2)c2cc(Cl)ccc2n(Cc2ccccc2)c1=O,,c1ccncc1,,,,val
US20100298288A1,CC(C)(C)OC(=O)NCC1CCNCC1.FC(F)(F)c1ccc(Br)nc1>>CC(C)(C)OC(=O)NCC1CCN(c2ccc(C(F)(F)F)cn2)CC1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20140296225A1,Cc1c(CCN2CCNCC2=O)ccc2c1COC2=O.Cc1c([C@@H]2CO2)ccc2c1COC2=O>>Cc1c(CCN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2=O)ccc2c1COC2=O,,CCO,,,,val
US06451834B1,O=C1CCc2ccccc21.O=Cc1ccsc1>>O=C1C(=Cc2ccsc2)Cc2ccccc21,,CC(=O)O,,C1CCNCC1,,val
US20090252679A1,FCCCBr.Oc1ccc(-c2cn3cc(Br)ccc3n2)cc1>>FCCCOc1ccc(-c2cn3cc(Br)ccc3n2)cc1,,ClC(Cl)Cl,,O,O=C([O-])[O-].[K+].[K+],val
US20080207645A1,CC1(C)CC(=O)CCO1.N#CCC#N.S=C=S>>CC1(C)Cc2c(C#N)c(N)sc(=S)c2CO1,,CO,,CCN(CC)CC,,val
US04874756,CC(=O)c1cccs1.CC1(C)C(=O)Nc2cc(N)ccc21>>CC1(C)C(=O)Nc2cc3[nH]c(-c4cccs4)cc3cc21,,ClCCl,,,,val
US20130210809A1,Cc1ccnc(Nc2nc(-c3c[nH]nc3C(=O)c3ccccc3)cs2)n1>>Cc1ccnc(Nc2nc(-c3c[nH]nc3C(O)c3ccccc3)cs2)n1,,CCO,O,[BH4-].[Na+],,val
US20100120860A1,CC(C)(C)OC(=O)N1CCC(N)CC1.N#Cc1nnc(Cl)s1>>CC(C)(C)OC(=O)N1CCC(Nc2nnc(C#N)s2)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20100152192A1,CCCCCBr.CCOC(=O)c1c(/C=C/c2cccc(OC(F)F)c2O)nc2sccn12>>CCCCCOc1c(/C=C/c2nc3sccn3c2C(=O)OCC)cccc1OC(F)F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05965743,ClCCCSc1ccccc1.O=Cc1ccc(O)cc1>>O=Cc1ccc(OCCCSc2ccccc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05919797,CS(=O)(=O)Cl.O=C(c1ccccc1)N1CCC(OCc2ccc3ccccc3c2Br)C(O)C1>>CS(=O)(=O)OC1CN(C(=O)c2ccccc2)CCC1OCc1ccc2ccccc2c1Br,,C1CCOC1,,CCN(CC)CC,,val
US20140163000A1,CNc1cc(N2CCN(C)CC2)c([N+](=O)[O-])cn1>>CNc1cc(N2CCN(C)CC2)c(N)cn1,[Pd],CO,,,,val
US20100125062A1,Fc1ncccc1Br.O=C1CCOCC1>>OC1(c2cccnc2F)CCOCC1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20130059834A1,II.c1n[nH]c2c1CCCCC2>>Ic1n[nH]c2c1CCCCC2,,CN(C)C=O,,[K+].[OH-],,val
US20100081692A1,COC(=O)/C=C/c1cc(F)ccc1OC[C@@](C)(O)CNC1CCN(Cc2ccc(Cl)cc2)CC1>>COC(=O)CCc1cc(F)ccc1OC[C@@](C)(O)CNC1CCN(Cc2ccc(Cl)cc2)CC1,[Pt],CCOC(C)=O,,,,val
US04589905,N#Cc1c(C(=O)O)cnn1-c1ccc(Cl)cc1.NC1CC1>>N#Cc1c(C(=O)NC2CC2)cnn1-c1ccc(Cl)cc1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20150274777A1,C[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C.O=C(O)c1cccc(Cl)c1Cl>>C[C@H](NC(=O)c1cccc(Cl)c1Cl)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05665718,CCCBr.CCN(C(C)C)C(C)C.CN(C)C=O.NCc1noc(-c2ncn3c2[C@@H]2CCN2C(=O)c2sccc2-3)n1>>CCCN(CCC)Cc1noc(-c2ncn3c2[C@@H]2CCN2C(=O)c2sccc2-3)n1,,CN(C)C=O,,,,val
US20140206681A1,CCOC(=O)CBr.COC(=O)c1ccc(CO)nc1>>CCOC(=O)COCc1ccc(C(=O)OC)cn1,,C1CCOC1,,[H-].[Na+],,val
US20030125558A1,CCOC(=O)CBr.O=Cc1cc(N2CCN(Cc3ccccc3)CC2)ccc1O>>CCOC(=O)COc1ccc(N2CCN(Cc3ccccc3)CC2)cc1C=O,,CCOC(C)=O,CN1CCCC1=O,O,O=C([O-])[O-].[K+].[K+],val
US04311696,CC(C)C(C#N)c1ccccc1.O=[N+]([O-])O>>CC(C)C(C#N)c1ccc([N+](=O)[O-])cc1,,O=S(=O)(O)O,,,,val
US20060142612A1,Nc1ccccc1C(=O)c1ccccc1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>O=C(c1ccccc1)c1ccccc1NS(=O)(=O)c1ccc([N+](=O)[O-])cc1,,ClCCl,,c1ccncc1,,val
US20040038993A1,CCOC(=O)c1cnn2c(C3CCCCC3)c(-c3ccc(-c4cccc(OC)c4)cc3)cnc12>>COc1cccc(-c2ccc(-c3cnc4c(C(=O)O)cnn4c3C3CCCCC3)cc2)c1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20040116461A1,O=C(Cl)C(=O)Cl.O=C(O)c1ccc(-n2nc3c4ccccc4[nH]c(C4CC4)c-3c2=O)cc1>>O=C(Cl)c1ccc(-n2nc3c4ccccc4[nH]c(C4CC4)c-3c2=O)cc1,,ClCCl,,CN(C)C=O,,val
US20140163025A1,COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccc(OC6CCOCC6)cc5F)ccc(F)c43)ccc21>>O=C(O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccc(OC6CCOCC6)cc5F)ccc(F)c43)ccc21,,CCO,,[K+].[OH-],,val
US20040127465A1,O=Cc1cc(Cl)ccc1OCc1ccccc1>>OCc1cc(Cl)ccc1OCc1ccccc1,,CO,O,Cl,[BH4-].[Na+],val
US06075036,CCc1c(-c2ccc(OC)cc2)c2ccc3cc(OC)cc1n32>>CCc1c(-c2ccc(O)cc2)c2ccc3cc(O)cc1n32,,ClCCl,,BrB(Br)Br,,val
US20040019016A1,Cc1ccc(Cl)c(O)c1.O=C(Cl)c1ccccc1>>Cc1ccc(Cl)c(OC(=O)c2ccccc2)c1,,ClCCl,,CCN(CC)CC,,val
US20160016908A1,CC(=O)N1c2ccc(C3=CCN(C(=O)OC(C)(C)C)CC3)cc2[C@H](Nc2nccc(C)n2)[C@@H](C)[C@@H]1C1CC1>>CC(=O)N1c2ccc(C3=CCNCC3)cc2[C@H](Nc2nccc(C)n2)[C@@H](C)[C@@H]1C1CC1,,C1COCCO1,,Cl,,val
US05532370,Brc1cccc(Br)c1.OB(O)c1ccc(Cl)cc1>>Clc1ccc(-c2cccc(Br)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US04831029,COC(=O)C1CN(Cc2ccccc2)CCC1=O.CSc1n[nH]c(N)n1>>CSC1=NC2=NC3=C(CN(Cc4ccccc4)CC3=O)CN2N1,,CC(=O)O,,Cl,[NH4+].[OH-],val
US20160039745A1,COC(=O)[C@]1(c2cccc(F)c2C)C=C(c2cncc(F)c2)CC1>>COC(=O)[C@@]1(c2cccc(F)c2C)CC[C@@H](c2cncc(F)c2)C1,[Pd],CO,,O=C[O-].[NH4+],,val
US20100317582A1,C[C@@H](N)c1cccc2ccccc12.O=C1CCC(C(=O)O)C1>>C[C@@H](NC1CCC(C(=O)O)C1)c1cccc2ccccc12,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060257987A1,CCc1ccc(OC)cc1.O=C(Cl)C1CCCC1>>CCc1ccc(O)c(C(=O)C2CCCC2)c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20160115119A1,Cc1ncccc1C(=O)O.N[C@@H]1CCc2c(F)cc(Cl)cc21.O=Cc1cccnc1.[C-]#[N+]C1=CCC(c2ccccc2)CC1>>Cc1ncccc1C(=O)N([C@@H](C(N)=O)c1cccnc1)[C@@H]1CCc2c(F)cc(Cl)cc21,,CCN(CC)CC,,CO,Cl,val
US20140235647A1,COc1ccc(F)cc1C(=O)c1nccc(-c2cnccc2C)c1F.NO>>COc1ccc(F)cc1/C(=N/O)c1nccc(-c2cnccc2C)c1F,,c1ccncc1,,Cl,,val
US20160152612A1,COC(=O)c1c(C)nc2ccccc2c1Cl.O=C1CCC(=O)N1Br>>COC(=O)c1c(CBr)nc2ccccc2c1Cl,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20150299121A1,CCOC(=O)C1CCCC1.O=S(=O)(c1ccccc1)N(F)S(=O)(=O)c1ccccc1>>CCOC(=O)C1(F)CCCC1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20010027207A1,CSc1ccc(C=O)s1.O=C1Cc2ccccc2N1>>CSc1ccc(C=C2C(=O)Nc3ccccc32)s1,C1CCNCC1,CCO,,,,val
US20090306133A1,CC(=O)NCCC1CCN(C(=O)OC(C)(C)C)CC1.O=C(O)C(F)(F)F>>CC(=O)NCCC1CC[NH2+]CC1.O=C([O-])C(F)(F)F,,ClCCl,,,,val
US20080021059A1,CCNC(=O)Nc1nc2cc(-c3cccnc3)cc(C(=O)OC)n2n1.CN>>CCNC(=O)Nc1nc2cc(-c3cccnc3)cc(C(=O)NC)n2n1,,CCO,,,,val
US05478838,COC(=O)C1CCC(C(C)(C)NC(C)=O)CC1>>COC(=O)[C@@H]1CC[C@@H](C(C)(C)NC(C)=O)CC1,,CO,,Cl,CC(C)(C)[O-].[K+],val
US20160226001A1,Brc1ccc2sc3ccc(Br)cc3c2c1.OB(O)c1cc(-c2ccccc2)cc(-c2ccccc2)c1>>Brc1ccc2sc3ccc(-c4cc(-c5ccccc5)cc(-c5ccccc5)c4)cc3c2c1,c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd-4]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20060142265A1,O=C(Cl)OCc1ccccc1.O=C1CNCc2cc(Br)cnc2N1>>O=C1CN(C(=O)OCc2ccccc2)Cc2cc(Br)cnc2N1,,ClCCl,,CCN(CC)CC,,val
US04543352,CCO.NN.O=C1c2ccccc2C(=O)N1c1cccc2ccccc12>>NCCCOc1ccc2cccc(N3CCCC3)c2c1,,CCO,,O,,val
US05401736,COC(=O)[C@@H]1Cc2c(ncn2Cc2ccc([N+](=O)[O-])c(C)c2)CN1.O=C(O)C(c1ccccc1)c1ccccc1>>COC(=O)[C@@H]1Cc2c(ncn2Cc2ccc([N+](=O)[O-])c(C)c2)CN1C(=O)C(c1ccccc1)c1ccccc1,,CC#N,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20080188506A1,CC(C)(C)N=C=O.O=C1Nc2cc(Cl)ccc2C12C(c1ccc(Cl)cc1)CCNC2c1cccc(F)c1>>CC(C)(C)NC(=O)N1CCC(c2ccc(Cl)cc2)C2(C(=O)Nc3cc(Cl)ccc32)C1c1cccc(F)c1,,ClCCl,,,,val
US05929103,C=Cc1ccccc1.N#CN.O=C1CCC(=O)N1Br>>N#CNC(CBr)c1ccccc1,,ClCCl,,,,val
US20120295884A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@@H](c1ccccc1)N1CC[C@@H](C)[C@H]1C(=O)OCc1ccccc1>>C[C@@H]1CCN(C(=O)OC(C)(C)C)[C@@H]1C(=O)O,,CO,,,,val
US20090298807A1,CCOC(OCC)c1cccc(CCOS(C)(=O)=O)c1.Cc1ccc(C(=O)N2CCOC3(CCNCC3)C2)s1>>CCOC(OCC)c1cccc(CCN2CCC3(CC2)CN(C(=O)c2ccc(C)s2)CCO3)c1,,CC#N,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20140221361A1,C=C(CN(C)CCN(C)C)[C@@H]1CC[C@]2(C(=O)NCCN(C)C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC(C)(C)C)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(CN(C)CCN(C)C)[C@@H]1CC[C@]2(C(=O)NCCN(C)C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050090669A1,COC(=O)c1cc(Oc2ccc3c(c2)C[C@@H](N(C[C@H](O)c2cccc(Cl)c2)C(=O)OC(C)(C)C)CC3)ccc1Cl>>CC(C)(C)OC(=O)N(C[C@H](O)c1cccc(Cl)c1)[C@H]1CCc2ccc(Oc3ccc(Cl)c(C(=O)O)c3)cc2C1,,CO,,Cl,[Na+].[OH-],val
US20030236278A1,CN(C)CCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21.ClCCCl>>CNCCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21.Cl,,ClCCCl,,CC(Cl)OC(=O)Cl,,val
US20090227648A1,C[C@H](N)c1ccc(F)cc1.O=[N+]([O-])c1ccc(N[C@@H](CO)c2ccc(F)cc2)c(F)c1Nc1cc(C2CC2)[nH]n1>>C[C@H](Nc1c(F)cc([N+](=O)[O-])c(Nc2cc(C3CC3)[nH]n2)c1F)c1ccc(F)cc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20060100207A1,CCOC(=O)C=C(C)Nc1cccc(C(F)(F)F)c1.N#CCC#N.N#Cc1ccc(C=O)cc1>>CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(N)=C(C#N)C1c1ccc(C#N)cc1,,CCO,,C1CCNCC1,,val
US20060089375A1,CC(C)(C)OC(=O)NCc1ccc(C(=O)NC2CC2)cc1.Cl>>Cl.NCc1ccc(C(=O)NC2CC2)cc1,,C1COCCO1,,CO,,val
US20050137215A1,CC(C)(C)OC(=O)N1CC2CCCCC2C1C(=N)NO.O=C(c1ncc[nH]1)c1ncc[nH]1>>CC(C)(C)OC(=O)N1CC2CCCCC2C1c1noc(=O)[nH]1,,C1CCOC1,,,,val
US04889851,CI.COc1ccc2c(c1)NC(=O)N(c1ccc(Cl)cc1)S2(=O)=O>>COc1ccc2c(c1)N(C)C(=O)N(c1ccc(Cl)cc1)S2(=O)=O,,CN(C)C=O,,[H-].[Na+],,val
US04013645,CSCC1=C(C(=O)O)N2C(=O)[C@@H](NC=O)[C@H]2SC1.Cl>>CSCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1.Cl,,C1COCCO1,,,,val
US20110034469A1,CCO[C@@H]1C[C@@H]2CN(C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C3CCCCC3)[C@H](C(=O)NC(c3ccccc3)C(F)(F)F)CN2C1>>CCO[C@@H]1C[C@@H]2CN(C(=O)[C@@H](NC(=O)[C@H](C)NC)C3CCCCC3)[C@H](C(=O)NC(c3ccccc3)C(F)(F)F)CN2C1,,CCOC(C)=O,Cl,,,val
US20130225567A1,C#Cc1ccccc1.CC(C)(C)OC(=O)Nc1ccc(N)c(Br)n1>>CC(C)(C)OC(=O)Nc1ccc(N)c(C#Cc2ccccc2)n1,[Cu]I,C1CCOC1,CC#N,CCN(CC)CC,,val
US20110301143A1,CC(C)(C)OC(=O)N1CCN(c2cnc(C#N)cn2)CC1.[N-]=[N+]=[N-].[NH4+]>>CC(C)(C)OC(=O)N1CCN(c2cnc(-c3nn[nH]n3)cn2)CC1,,CN(C)C=O,,[Na+].[OH-],,val
US20120322841A1,COc1ccc(C2=CCCc3[nH]ncc32)cc1>>COc1ccc(C2CCCc3[nH]ncc32)cc1,[Pd],CCO,,C1CCOC1,,val
US20120277217A1,CCOC(=O)c1ccc(COc2ccccc2-c2c[nH]cn2)cc1.[Li]O>>O=C([O-])c1ccc(COc2ccccc2-c2c[nH]cn2)cc1.[Li+],,CO,O,,,val
US04029787,CN(Cc1ccco1)C(=O)c1ccc(Cl)c(S(N)(=O)=O)c1.CN1CCNCC1>>CN1CCN(c2ccc(C(=O)N(C)Cc3ccco3)cc2S(N)(=O)=O)CC1,,O,,Cl,,val
US20070213325A1,ClC(Cl)(Cl)C(Cl)(Cl)Cl.Cn1cnc(-c2ccccc2)c1>>Cn1cc(-c2ccccc2)nc1Cl,,C1CCOC1,,[Li]CCCC,,val
US20020032340A1,C[C@H](OCCC(C)(C)O)C1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C>>C[C@H](OCCC(C)(C)O)C1=CC[C@H]2C3=CC=C4C[C@@H](O)C[C@H](O)[C@]4(C)[C@H]3CC[C@]12C,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080114007A1,CONC(=O)c1cn(-c2ccc(OC(F)(F)F)cc2)c2nc(Nc3ccc(C4CCNCC4)cc3)ncc2c1=O.NS(N)(=O)=O>>CONC(=O)c1cn(-c2ccc(OC(F)(F)F)cc2)c2nc(Nc3ccc(C4CCN(S(N)(=O)=O)CC4)cc3)ncc2c1=O,,C1COCCO1,,,,val
US04810636,CC1(C)C2=CC(=O)C=CC2=Nc2ccc(O)cc21.Cc1ccc(S(=O)(=O)N[C@@H](C)C(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)N[C@@H](C)C(=O)Oc2ccc3c(c2)C(C)(C)C2=CC(=O)C=CC2=N3)cc1,,C1CCOC1,,CCOC(C)=O,c1ccncc1,val
US05994378,CCCC(Oc1ccccc1COc1ccc2oc(-c3nc(C(C)(C)C)cs3)cc2c1)C(N)=O>>CCCC(C#N)Oc1ccccc1COc1ccc2oc(-c3nc(C(C)(C)C)cs3)cc2c1,,CN(C)C=O,,O=P(Cl)(Cl)Cl,,val
US20060276464A1,CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2Cl)CC1>>O=S(=O)(NC1CCNCC1)c1cc(S(=O)(=O)c2ccccc2)ccc1Cl,,C1COCCO1,Cl,O=C([O-])O.[Na+],,val
US20140243527A1,C=C(C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CCOC(C)=O>>C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,CCOC(C)=O,,CC(C)=O,,val
US06894169B1,Cc1ccncc1.OCCBr>>Cc1cc[n+](CCO)cc1.[Br-],,CCO,,,,val
US20100261755A1,COC(=O)N1CC[C@@H](c2cc(=O)[nH]o2)C[C@@H]1Cc1ccccc1C(F)(F)F>>O=c1cc([C@@H]2CCN[C@@H](Cc3ccccc3C(F)(F)F)C2)o[nH]1,,Br,,CC(=O)O,,val
US20120322785A1,CCO.O=C(Nc1cc2ccc(Br)cc2cn1)C1CC1>>COc1ccc2cc(NC(=O)C3CC3)ncc2c1,[Cu]I,CCO,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US20080021032A1,BrCc1ccccc1.O=[N+]([O-])c1cc[nH]n1>>O=[N+]([O-])c1ccn(Cc2ccccc2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20120129811A1,CC(C)Oc1ccccc1N.S=C(Cl)Cl>>CC(C)Oc1ccccc1N=C=S,,ClC(Cl)Cl,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US04963544,CC(=O)S.CS(=O)(=O)O[C@@H]1C[C@@H](Cn2ccnc2)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1>>CC(=O)S[C@H]1C[C@@H](Cn2ccnc2)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20140303168A1,CC(C)(C)NS(=O)(=O)c1cncc(-c2nnc(Cl)c3c(-c4ccccc4)cccc23)c1.NCc1ccccn1>>CC(C)(C)NS(=O)(=O)c1cncc(-c2nnc(NCc3ccccn3)c3c(-c4ccccc4)cccc23)c1,,Cc1ccccc1,,,,val
US20110294776A1,CNC(=O)CCl.c1ccc(CN2CCNCC2)cc1>>CNC(=O)CN1CCN(Cc2ccccc2)CC1,,C1CCOC1,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20010041740A1,ClP(Cl)(Cl)(Cl)Cl.O=C(Nc1c([N+](=O)[O-])cc(C(F)(F)F)cc1[N+](=O)[O-])C(F)(F)C(F)(F)Cl>>O=[N+]([O-])c1cc(C(F)(F)F)cc([N+](=O)[O-])c1N=C(Cl)C(F)(F)C(F)(F)Cl,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20030186955A1,CC(=O)OC(C)=O.CC1(C)NC(=O)NC1=O>>CC(=O)N1C(=O)NC(=O)C1(C)C,O=S(=O)(O)O,,,,,val
US20080176830A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1CCSc2cc(-c3ccc(C(F)(F)F)cc3)ccc2N1>>CC(C)(C)OC(=O)N1C(=O)CCSc2cc(-c3ccc(C(F)(F)F)cc3)ccc21,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20110065739A1,COc1cccc(C(=O)CBr)c1.Oc1ccc(I)cc1>>COc1cccc(C(=O)COc2ccc(I)cc2)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090131461A1,COc1cc2c(Cl)ncnc2cc1OCc1ccccc1.O=C(Nc1ccc(O)cc1)c1ccccc1>>COc1cc2c(Oc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCc1ccccc1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20150065482A1,CC(C)(C)OC(=O)NCc1cc(C(N)=O)ccn1>>CC(C)(C)OC(=O)NCc1cc(C#N)ccn1,,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20090029994A1,Clc1ncc(Br)cn1.OCc1ccc(C(F)(F)F)cc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>OCc1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ncc(Br)cn1,,CCOC(C)=O,Cc1ccccc1,CCN(C(C)C)C(C)C,O,val
US20070270446A1,CC(=N)N.COC(=O)C(CCc1ccccc1)C(=O)c1cccc(F)c1OC>>COc1c(F)cccc1-c1[nH]c(C)nc(=O)c1CCc1ccccc1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20070185133A1,Clc1ncc(Br)c(-c2cccs2)n1.NCCN1CCNC1=O>>O=C1NCCN1CCNc1ncc(Br)c(-c2cccs2)n1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20100010057A1,Cc1nc(NC(=O)N[C@@H](COC(C)(C)C)C(=O)OC2CCCC2)sc1-c1ccc(Cl)c(S(C)(=O)=O)c1>>Cc1nc(NC(=O)N[C@@H](CO)C(=O)OC2CCCC2)sc1-c1ccc(Cl)c(S(C)(=O)=O)c1,,C1COCCO1,,Cl,,val
US20100249119A1,CC(C)(C#N)Oc1cccc(C(=O)Cl)c1Cl.Nc1cc(Nc2ccc3nc(NC(=O)C4CC4)sc3n2)ccc1F>>CC(C)(C#N)Oc1cccc(C(=O)Nc2cc(Nc3ccc4nc(NC(=O)C5CC5)sc4n3)ccc2F)c1Cl,,CC(=O)N(C)C,,O=C([O-])O.[Na+],,val
US20020009483A1,O=C1CN(c2ccc([N+](=O)[O-])cc2F)CCN1CCF>>Nc1ccc(N2CCN(CCF)C(=O)C2)c(F)c1,,CCOC(C)=O,CN(C)C=O,,,val
US06235771B1,CNc1ccccc1.O=C1CCC(=O)N1Br>>CNc1ccc(Br)cc1,,CN(C)C=O,,O,,val
US20150141406A1,COc1ncc(C#N)c2ccn(COCC[Si](C)(C)C)c12.O=C1CCC(=O)N1Br>>COc1ncc(C#N)c2c(Br)cn(COCC[Si](C)(C)C)c12,,CCOC(C)=O,,,,val
US06486330B1,CC(=O)O.O=C1C2CC3CC(C2)CC1C3.O=C1c2ccccc2C(=O)N1O>>O=C1C2CC3CC(C2)CC1C3.O=C1C2CC3CC1CC(O)(C3)C2,,CC(=O)O,,O=O,,val
US05260307,N[C@H](Cc1ccccc1)C(=O)OCc1ccccc1.O=S(=O)(Cl)c1ccc2ccccc2c1>>O=C(OCc1ccccc1)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc2ccccc2c1,,ClCCl,,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US04115397,CCI.CCc1ccncc1>>CCC(C)c1ccncc1,,N,,,,val
US20150284384A1,CB1OB(C)OB(C)O1.Cc1cc(C(=O)NC2CCOCC2)c(OS(=O)(=O)C(F)(F)F)c2nc(C(F)(F)F)c(CC3CCC(F)(F)CC3)n12>>Cc1c(C(=O)NC2CCOCC2)cc(C)n2c(CC3CCC(F)(F)CC3)c(C(F)(F)F)nc12,,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US06509361B1,Cc1cc(-c2ccnc(Cl)c2)n(-c2cccc(F)c2)n1.NCc1cccnc1>>Cc1cc(-c2ccnc(NCc3cccnc3)c2)n(-c2cccc(F)c2)n1,,O,,,,val
US05981572,NCCCc1cccc2c1CCO2.O=C(Cl)C1CCC1>>O=C(NCCCc1cccc2c1CCO2)C1CCC1,,ClCCl,,CCN(CC)CC,Cl,val
US20160022626A1,CC(=O)c1ccc(O)cc1.O=C(NCCCCCO)OCC1c2ccccc2-c2ccccc21>>CC(=O)c1ccc(OCCCCCNC(=O)OCC2c3ccccc3-c3ccccc32)cc1,,CCOC(C)=O,Cc1ccccc1,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04734416,ClCl.O=C1CCc2c(O)cccc2N1>>O=C1CCc2c(ccc(Cl)c2O)N1,,CC(=O)O,,O,,val
US20080146562A1,O=P(Cl)(Cl)Cl.O=c1[nH]c(C=Cc2ccc([N+](=O)[O-])o2)nc2cc(F)c(N3CCOCC3)cc12>>O=[N+]([O-])c1ccc(C=Cc2nc(Cl)c3cc(N4CCOCC4)c(F)cc3n2)o1,,O=P(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US06251897B1,CCCCI.COc1ccc(C=O)cc1O>>CCCCOc1cc(C=O)ccc1OC,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US05159114,COCCNC(=O)c1ccc(SC)c([N+](=O)[O-])c1>>COCCNC(=O)c1ccc(SC)c(N)c1,[Pd],CCOC(C)=O,,[H][H],,val
US20070185109A1,N#C[Cu].O=C1C(Br)=C(c2ccccc2)c2ccc(OCCCc3ccccc3)cc21>>N#CC1=C(c2ccccc2)c2ccc(OCCCc3ccccc3)cc2C1=O,,CN(C)C=O,,[Cl-].[NH4+],,val
US20100197655A1,COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3ccc(C(F)(F)F)cc3-c3cn(C4CCCCO4)nc3[N+](=O)[O-])cc2F)c(OC)c1>>Nc1n[nH]cc1-c1cc(C(F)(F)F)ccc1Oc1cc(F)c(S(=O)(=O)Nc2nncs2)cc1Cl,[Fe],CCO,,[Cl-].[NH4+],,val
US20100144722A1,C1COCCN1.Cc1noc(C)c1-c1cc(Cl)nc(Cl)n1>>Cc1noc(C)c1-c1cc(N2CCOCC2)nc(Cl)n1,,CO,,CCN(C(C)C)C(C)C,,val
US20150166564A1,CCOC(=O)CP(=O)(OCC)OCC.O=Cc1cnco1>>CCOC(=O)/C=C/c1cnco1,,C1CCOC1,,[H-].[Na+],,val
US20090233978A1,CCI.CN(C)C=O.Clc1ccc(C23CNCC2C3)cc1Cl>>CC(C)N1CC2CC2(c2ccc(Cl)c(Cl)c2)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20100240653A1,O=S(=O)(O)c1ccc(-c2ccc(CCCl)cc2)cc1.O=S(Cl)Cl>>O=S(=O)(Cl)c1ccc(-c2ccc(CCCl)cc2)cc1,,CCCCCCC,,CC(=O)N(C)C,,val
US06191292B1,COC(=O)[C@H]1C[C@@H](O)[C@@H](C)[C@@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C1.Cc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)[C@H]1C[C@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)[C@@H](C)[C@H](OS(=O)(=O)c2ccc(C)cc2)C1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20130005771A1,CO.COc1ccc(C=CC(=O)O)cc1OC>>COC(=O)C=Cc1ccc(OC)c(OC)c1,,O=S(=O)(O)O,,,,val
US20020037888A1,CCC1(c2cccc(OC)c2)CCCCN(CCNC(=O)NC(C)(C)C)C1=O>>CCC1(c2cccc(OC)c2)CCCCN(CCNC(N)=O)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US05316755,BrCCC(c1ccccc1)c1ccccc1.Oc1c(I)cc(I)cc1I>>Ic1cc(I)c(OCCC(c2ccccc2)c2ccccc2)c(I)c1,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20140045862A1,COc1ccc(CN(c2ncns2)S(=O)(=O)c2cc(F)c(O[C@H]3CCCC[C@@H]3c3ccnn3C)cc2F)c(OC)c1>>Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(S(=O)(=O)Nc2ncns2)cc1F,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20110257151A1,CC(C)(C)c1ccc(-c2cccc(C3Nc4c(cc(Cl)cc4C(=O)O)CC3(C)C)c2)cc1.CS(N)(=O)=O>>CC(C)(C)c1ccc(-c2cccc(C3Nc4c(cc(Cl)cc4C(=O)NS(C)(=O)=O)CC3(C)C)c2)cc1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20050233988A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C(CNC(=O)c1ccccc1)Cc1cc(Br)ccc1Cl>>Clc1ccc(Br)cc1Cc1cnc(-c2ccccc2)s1,,Cc1ccccc1,,,,val
US20100292210A1,CN(C)C(=O)Cl.Clc1ccc2c(n1)O[C@H](c1ccccc1)CNC2>>CN(C)C(=O)N1Cc2ccc(Cl)nc2O[C@H](c2ccccc2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04152433,CON=C(C(=O)CBr)C(=O)NC1C(=O)N2C(C(=O)OCC(Cl)(Cl)Cl)=CC(C)S[C@H]12.NC(N)=S>>CON=C(C(=O)NC1C(=O)N2C(C(=O)OCC(Cl)(Cl)Cl)=CC(C)S[C@H]12)c1csc(N)n1,,CCO,,,,val
US20160115126A1,C=CC(=O)Cl.Cc1[nH]c2c(C(N)=O)cc(F)c(-c3cccc4c3C(F)(F)CNC4)c2c1C>>C=CC(=O)N1Cc2cccc(-c3c(F)cc(C(N)=O)c4[nH]c(C)c(C)c34)c2C(F)(F)C1,,ClCCl,,,,val
US20100016401A1,O=C=O.c1ccc2c(c1)CCCO2>>O=C(O)c1cccc2c1OCCC2,,CCCCCC,CCOCC,[Li]CCCC,,val
US20140045818A1,[Cr+6].[O-2].[O-2].[O-2].[O-][I+3]([O-])([O-])O>>[Cr+6].[O-2].[O-2].[O-2].[O-][I+3]([O-])([O-])O,,CC#N,,,,val
US20120142705A1,COC(=O)C(CC(C)C)N1C(=O)C(=O)c2ccccc21>>CC(C)CC(C(=O)O)N1C(=O)C(=O)c2ccccc21,,C1CCOC1,O,[Li+].[OH-],,val
US20130190312A1,CC(=O)c1c(C)cc(O)cc1C.COc1cnc(Cl)nc1>>COc1cnc(Oc2cc(C)c(C(C)=O)c(C)c2)nc1,[Cu],CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20100240656A1,CC(C)N(CCCn1c(Sc2cc3c(cc2I)OCO3)nc(C(N)=O)c1N)C(=O)OC(C)(C)C>>CC(C)NCCCn1c(Sc2cc3c(cc2I)OCO3)nc(C(N)=O)c1N,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060160794A1,CC(C)(C)OC(=O)N1CCCC1(C)c1ccccc1Cl.Cl>>CC1(c2ccccc2Cl)CCCN1.Cl,,CC(=O)O,Cl,,,val
US04171303,CC1=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(N)[C@H]2SC1.O=C(Oc1ccccc1)C(C(=O)Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl)c1ccccc1>>CC1=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(NC(=O)C(C(=O)Oc3ccccc3)c3ccccc3)[C@H]2SC1,,ClCCl,,CCN(CC)CC,Cl,val
US20090176786A1,CN(C(=O)NC(=O)c1c(F)cccc1F)c1ccc(SC(F)(F)F)cc1F.CN(C)C(=O)Cl>>CN(C)C(=O)N(C(=O)c1c(F)cccc1F)C(=O)N(C)c1ccc(SC(F)(F)F)cc1F,,CN1CCCC1=O,,[H-].[Na+],,val
US20060004017A1,CCO.CCOC(=O)c1cc2c(Br)c(O)ccc2[nH]1>>COc1ccc2[nH]c(C(=O)O)cc2c1Br,,O,,[K+].[OH-],,val
US20160158207A1,CNCCO.O=[N+]([O-])c1cc(C(F)F)c(Br)cc1F>>CN(CCO)c1cc(Br)c(C(F)F)cc1[N+](=O)[O-],,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20040082780A1,FC(F)(F)c1ccc(-c2cc(Cl)ncn2)cc1.Oc1ccc2cc[nH]c2c1>>FC(F)(F)c1ccc(-c2cc(Oc3ccc4cc[nH]c4c3)ncn2)cc1,,C1COCCO1,,[Na+].[OH-],,val
US04517195,CC(C)(C)OC(=O)NCC(=O)O.CNn1cccc1C(=O)c1ccccc1Cl>>CN(C(=O)CNC(=O)OC(C)(C)C)n1cccc1C(=O)c1ccccc1Cl,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20110015238A1,CC(C)(C)[Si](C)(C)OC[C@H]1CCC(=O)N1Cc1nc(/C=C/C(=O)O)cs1.CCCCI>>CCCCOC(=O)/C=C/c1csc(CN2C(=O)CC[C@@H]2CO[Si](C)(C)C(C)(C)C)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20020147160A1,C[C@@]1(O)[C@H](OCc2ccc(Cl)cc2Cl)[C@@H](COCc2ccc(Cl)cc2Cl)O[C@H]1n1ncc2c(N)ncnc21>>C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1ncc2c(N)ncnc21,,ClCCl,,ClB(Cl)Cl,,val
US20060142265A1,CN.Cn1ccc2ccc(C=O)cc21>>CNCc1ccc2ccn(C)c2c1,,CO,,O,[BH4-].[Na+],val
US05750726,C=CC#N.N#CC(c1ccc(Cl)cc1)N(Cc1ccccc1)C(=O)C(F)(F)F>>N#Cc1cc(C(F)(F)F)n(Cc2ccccc2)c1-c1ccc(Cl)cc1,,Cc1ccccc1,,CS(=O)(=O)O,,val
US20130338066A1,CC(C)(O)C(c1ccc(-c2ccccc2)cc1)S(N)(=O)=O.CCOC(OCC)(OCC)OCC>>CCOC1=NS(=O)(=O)C(c2ccc(-c3ccccc3)cc2)C(C)(C)O1,,CC(=O)O,,,,val
US04381297,CCOP(=O)(CC(=O)N1CCC[C@H]1C(=O)OCc1ccccc1)C(CCc1ccccc1)CC(=O)c1ccccc1>>O=C(CC(CCc1ccccc1)P(=O)(O)CC(=O)N1CCC[C@H]1C(=O)OCc1ccccc1)c1ccccc1,,ClCCl,,C[Si](C)(C)Br,,val
US20120149711A1,Cc1ccc(-c2ncccn2)c(C(=O)N2C[C@@H](C)CC[C@H]2CNC(=O)C(F)(F)F)n1>>Cc1ccc(-c2ncccn2)c(C(=O)N2C[C@@H](C)CC[C@H]2CN)n1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US04001258,CCOC(=O)CC(=N)N.N#Cc1cccc(C=O)c1.O=C1CCCC(=O)C1>>CCOC(=O)C1=CN(c2cccc(C#N)c2)C2=C(C1)C(=O)CCC2,,CCO,,CN(C)C=O,,val
US06495551B1,CC(=O)NC[C@H]1CN(c2ccc(-n3cnc(CO)c3)c(F)c2)C(=O)O1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(=O)NC[C@H]1CN(c2ccc(-n3cnc(CN=[N+]=[N-])c3)c(F)c2)C(=O)O1,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US04695654,CS(=O)(=O)Cl.OCCC(F)(F)COCc1ccccc1>>CS(=O)(=O)OCCC(F)(F)COCc1ccccc1,,ClCCl,,c1ccncc1,,val
US20060025597A1,CCCCCNc1cccc(C(=O)O)c1C(=O)O.NC1CCC(=O)NC1=O>>CCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,,CC(=O)O,,Cl,,val
US20050070592A1,Cn1c(-c2ccccc2)c(Cc2ccccc2)c2cc(-c3ccc(O)cc3)ccc21.N#CCBr>>Cn1c(-c2ccccc2)c(Cc2ccccc2)c2cc(-c3ccc(OCC#N)cc3)ccc21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130028919A1,CC(C)(C)OC(=O)[C@@H]1CCCN1.CCN(C(C)C)C(C)C.CCOC(C)=O>>CC(C)(C)OC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1,,ClCCl,,Cl,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150291655A1,CSC1CCC2(CC1)OCCO2.O=C(OO)c1cccc(Cl)c1>>CS(=O)(=O)C1CCC2(CC1)OCCO2,,ClCCl,,[Na+].[OH-],,val
US04535182,C=CCC1C(=O)C=CC1(C)OC(C)=O>>C=CCC1=C(C)C(OC(C)=O)CC1=O,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20060178378A1,Cc1cccc(NC(=O)Nc2ccc(-c3ccnc(Cl)c3C#N)cc2)c1.NN>>Cc1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(N)c34)cc2)c1,,CCCCO,,O,,val
US20140100231A1,N#Cc1cc(Cl)cc(Oc2c(O)nc[nH]c2=O)c1.O=C([O-])C(F)(F)Cl>>N#Cc1cc(Cl)cc(Oc2c(OC(F)F)nc[nH]c2=O)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20150045378A1,COC(=O)CCc1cccc(O)c1.COc1ccc(F)c(-c2ccc(CO)nc2CC(C)(C)C)c1>>COC(=O)CCc1cccc(OCc2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)n2)c1,,C1CCOC1,Cc1ccccc1,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120172411A1,CCCCC/C=C\C/C=C\CCCCCCCC=O.CN(C)CCCN>>CCCCC/C=C\C/C=C\CCCCCCCCNCCCN(C)C,,C1CCOC1,CCOC(C)=O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080214615A1,CNCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.Cc1cccc(N=C=O)c1>>Cc1cccc(NC(=O)N(C)Cc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c1,,C1CCOC1,,CCN(CC)CC,Cl,val
US04689339,BrBr.CC(=O)C1(C)Cc2ccccc2C1>>CC1(C(=O)CBr)Cc2ccccc2C1,,ClCCl,,,,val
US05104867,CNC(=O)[C@@H]1C[C@H](SCc2ccc(OC)cc2)CN1CCO.CS(=O)(=O)Cl>>CNC(=O)[C@@H]1C[C@H](SCc2ccc(OC)cc2)CN1CCOS(C)(=O)=O,,C1CCOC1,,CCN(CC)CC,,val
US20040121994A1,O=Cc1cccc(F)c1F.Sc1ccc(Cl)cc1>>O=Cc1cccc(F)c1Sc1ccc(Cl)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160039812A1,CCOC(=O)CBr.N#Cc1ccc(C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)NCC3)cc1>>COC(=O)CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)NCC2)C1c1ccc(C#N)cc1,,CN(C)C=O,,O,CC(C)[N-]C(C)C.[Li+],val
US20120029026A1,COC(=O)c1cccc(OCc2nc3ccc(Oc4ncccc4Cl)cc3n2C)c1>>Cn1c(COc2cccc(C(=O)O)c2)nc2ccc(Oc3ncccc3Cl)cc21,,C1COCCO1,,[Na+].[OH-],,val
US20050020654A1,CCCc1nc2c(C)cc(Br)cc2[nH]1.CCOC(=O)CBr>>CCCc1nc2c(C)cc(Br)cc2n1CC(=O)OCC,,C1CCOC1,,[H-].[Na+],,val
US20140371201A1,CCOC(=O)/C=C/c1cc(SCc2ccccc2)ccc1Nc1cc(Br)ccc1OC>>COc1ccc(Br)cc1-n1c(=O)ccc2cc(SCc3ccccc3)ccc21,,CO,,C[O-].[Na+],,val
US20100240706A1,COC(=O)C1(c2ccc(Br)cc2)CCOCC1>>OCC1(c2ccc(Br)cc2)CCOCC1,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20100179143A1,CCCC[Sn](CCCC)(CCCC)c1ccco1.O=S(=O)(Nc1ccc(F)cc1F)c1cncc(-c2ccc3nccc(Cl)c3n2)c1>>O=S(=O)(Nc1ccc(F)cc1F)c1cncc(-c2ccc3nccc(-c4ccco4)c3n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20100210452A1,CC(=O)/C=C/C=O.CCC/C=C/C=NS(=O)(=O)c1ccc(OC)cc1>>CCC[C@H]1C=CN(S(=O)(=O)c2ccc(OC)cc2)C(=O)[C@H]1CC(C)=O,,ClC(Cl)Cl,,,,val
US20120264737A1,COC(=O)c1ccc(C)cc1Br.II>>COC(=O)c1cc(I)c(C)cc1Br,,CC(=O)O,,O=S(=O)(O)O,,val
US20160016947A1,Cc1ccc([C@H]2C[C@@H]2CO)nc1.Cn1[nH]c(=O)cc(Br)c1=O>>Cc1ccc([C@H]2C[C@@H]2COc2cc(Br)c(=O)n(C)n2)nc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100168244A1,CC(=O)Cl.COc1ccc2cccc(C(O)CN)c2c1>>COc1ccc2cccc(C(O)CNC(C)=O)c2c1,,CCOC(C)=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20010020097A1,CC(Nc1ccc(Cl)c(Cl)c1)C(=O)O.COC(=O)[C@@H](N)Cc1ccccc1>>COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)Nc1ccc(Cl)c(Cl)c1,,CCOC(C)=O,,Cl,,val
US20160221972A1,CC[C@H]1COc2cc(C(=O)OC)ccc2CN1.COc1ccc(CBr)cc1>>CC[C@H]1COc2cc(C(=O)OC)ccc2CN1Cc1ccc(OC)cc1,,C1CCOC1,,[H-].[Na+],,val
US05053509,Nc1ccc(F)c(Cl)c1.O=C(Cl)CCCl>>O=C(CCCl)Nc1ccc(F)c(Cl)c1,,CC(C)=O,,,,val
US20130116243A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)NC(=O)CCN4)cc2)CCC1.CI>>CN1C(=O)CCNc2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc21,,CN(C)C=O,,O,[H-].[Na+],val
US20120010235A1,CCN1C(C(=O)OC(C)(C)C)C(c2cccc(Cl)c2)C(C#N)(c2ccc(Cl)cc2)C1CC(C)(C)C>>CCN1C(C(=O)O)C(c2cccc(Cl)c2)C(C#N)(c2ccc(Cl)cc2)C1CC(C)(C)C,,CC#N,,O=S(=O)(O)O,,val
US04933501,CC(C)(C)OO.CC(C)=CCC/C(C)=C/CCl>>CC(C)=CCC/C(C)=C/COOC(C)(C)C,,O=S1(=O)CCCC1,,[K+].[OH-],,val
US05238837,COC(=O)CCCCCCCCCCCCCCCCCCCCCOS(=O)(=O)c1ccc(C)cc1.O=C1NC(=O)c2ccccc21>>COC(=O)CCCCCCCCCCCCCCCCCCCCCN1C(=O)c2ccccc2C1=O,,CN(C)C=O,,[K],,val
US20150361101A1,OCC(O)c1cnc(Cl)cc1-c1cc2c(F)cccc2[nH]1>>O=Cc1cnc(Cl)cc1-c1cc2c(F)cccc2[nH]1,,C1CCOC1,O,O=S([O-])[O-].[Na+].[Na+],,val
US20110112062A1,CC(C)(C)OC(=O)NC1CNC1.O=C(NC1C2CC3CC(C2)CC1C3)Oc1ccc([N+](=O)[O-])cc1>>CC(C)(C)OC(=O)NC1CN(C(=O)NC2C3CC4CC(C3)CC2C4)C1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20150111935A1,CCCCCCC/C=C/C=C/C(=O)OCC>>CCCCCCC/C=C/C=C/C(=O)O,,CO,,Cl,[Na+].[OH-],val
US20060247262A1,CC(C)(C)C(=O)Cl.Nc1ccc2c(c1)OCCO2>>CC(C)(C)C(=O)Nc1ccc2c(c1)OCCO2,,CCOCC,,CCN(CC)CC,,val
US20020107253A1,O=CCCCC1CC(c2cccc([N+](=O)[O-])c2)=NO1.c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>O=[N+]([O-])c1cccc(C2=NOC(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2)c1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05919811,CCOC(=O)c1[nH]c2cc(Cl)cc(Cl)c2c1/C=C/C(=O)OC(C)(C)C.O=S(=O)(Cl)c1ccccc1>>CCOC(=O)c1c(/C=C/C(=O)OC(C)(C)C)c2c(Cl)cc(Cl)cc2n1S(=O)(=O)c1ccccc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20100029650A1,CC(C)OC(=O)N1CCC(C(C)Oc2cnc(-c3ccc(S(C)(=O)=O)cc3)cn2)CC1>>CC(C)OC(=O)N1CCC([C@H](C)Oc2cnc(-c3ccc(S(C)(=O)=O)cc3)cn2)CC1,,CO,,O=C=O,,val
US05710142,CCC(CC)(O[Si](C)(C)C)C(F)(F)C=O>>CCC(CC)(O[Si](C)(C)C)C(F)(F)CO,,C1CCOC1,CCO,[BH4-].[Na+],,val
US05240951,CC(C)N.O=C(O)c1snc(Cl)c1Cl>>CC(C)[NH3+].O=C([O-])c1snc(Cl)c1Cl,,C1CCOC1,,,,val
US20050054627A1,CCS(=O)(=O)C[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)OCc2ccccc2)C1=O>>CCS(=O)(=O)C[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](N)C1=O,,CCOCC,,Br,CC(=O)O,val
US20080207645A1,CCO.COCCN(C)c1nc(S)c(C#N)c2c1COC(C)(C)C2.NC(=O)CCl>>COCCN(C)c1nc2sc(C(N)=O)c(C)c2c2c1COC(C)(C)C2,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20150209445A1,O=C(CC(CC(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21)c1ccc([N+](=O)[O-])cc1)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21>>Nc1ccc(C(CC(=O)N2C[C@@H](CCl)c3c2cc(O)c2ccccc32)CC(=O)N2C[C@@H](CCl)c3c2cc(O)c2ccccc32)cc1,[Pd],C1CCOC1,O,O=C[O-].[NH4+],,val
US20090099155A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C(NCc1ccc(F)cc1)c1ccc(CSc2c(Cl)ccc3c2CCNCC3)cc1>>Fc1ccc(CNC(=S)c2ccc(CSc3c(Cl)ccc4c3CCNCC4)cc2)cc1,,C1COCCO1,,,,val
US20120115852A1,CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CS(C)=O.O=C1Nc2ccc(-c3ccc(Cl)cc3)cc2CN2CCNCC12>>CC(C)(C)[C@H](O)C(=O)N1CCN2Cc3cc(-c4ccc(Cl)cc4)ccc3NC(=O)C2C1,,CS(C)=O,O,On1nnc2ccccc21,,val
US20120115846A1,Nc1ccc(Br)cc1C(=O)O.O=C1CCOCC1>>O=C(O)c1cc(Br)ccc1NC1CCOCC1,,CC(=O)O,,O=S(=O)([O-])[O-].[Na+].[Na+],,val
US20160002177A1,Br.COc1cc(-c2ccc(F)cc2)c(N)c2c(=O)n(COCC[Si](C)(C)C)cnc12>>Br.Nc1c(-c2ccc(F)cc2)cc(O)c2nc[nH]c(=O)c12,,O,,,,val
US20050209241A1,CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3OC(C)C)CC2)c(F)c1.CON>>CON=C(C)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3OC(C)C)CC2)c(F)c1,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US06114527,CN(C)C=O.COC(C)(C)C.Clc1nc(Cl)nc(Cl)n1>>CN(C)C=NC=[N+](C)C.[Cl-],,COC(C)(C)C,,O=C=O,,val
US20150175594A1,O=C(OCc1ccccc1)c1cccnc1C(=O)Nc1sc2c(c1-c1nc(C(F)(F)F)no1)CCC(F)(F)C2>>O=C(O)c1cccnc1C(=O)Nc1sc2c(c1-c1nc(C(F)(F)F)no1)CCC(F)(F)C2,[Pd],CCOC(C)=O,CO,,,val
US20080287475A1,COc1cc(Nc2nc(Cl)nc(Cl)c2Cl)n[nH]1.COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)n[nH]1>>COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(Cl)c2Cl)n[nH]1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20150152112A1,CC(C)(C)OC(=O)Nc1ccc(Cl)cc1-c1cc2n(c(=O)c1)C(C(=O)CCl)CC2.CC(C)=C(Cl)N(C)C.C[Si](C)(C)C=[N+]=[N-].O=C([O-])O>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ccc(Cl)cc1-c1cc2n(c(=O)c1)C(C(=O)CCl)CC2,,CCOCC,ClCCl,Cl,,val
US20050026968A1,COc1cccc(CN)c1OC.O=C(Cl)c1ccc([N+](=O)[O-])o1>>COc1cccc(CNC(=O)c2ccc([N+](=O)[O-])o2)c1OC,,CCN(CC)CC,ClCCl,,,val
US20040127574A1,CCOC(=O)c1cccc2c([N+](=O)[O-])cccc12>>CCOC(=O)c1cccc2c(N)cccc12,[Pd],CCO,,C1CCOC1,,val
US20090275592A1,ClCCl.OCc1cc(Br)ccc1F>>CC(=O)c1cc(Br)ccc1F,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20100324030A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCCc1ccc2c(c1)OCCO2>>Cc1ccc(S(=O)(=O)OCCc2ccc3c(c2)OCCO3)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US05599813,CO.O=C(O)Cc1ccc(Br)cc1.O=[N+]([O-])c1cccc(OB(O)O)c1>>COC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)cc1,,CO,ClC(Cl)Cl,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20110275630A1,CC(C)(C)OC(=O)NCCBr.O=C1NCc2c(Br)cc(O)cc21>>CC(C)(C)OC(=O)NCCOc1cc(Br)c2c(c1)C(=O)NC2,,CN(C)C=O,,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20130096084A1,CC(C)(C)OC(=O)N[C@H]1CCCN(Cc2ccccc2)C1>>N[C@H]1CCCN(Cc2ccccc2)C1,,C1COCCO1,,Cl,,val
US05260316,COc1ccc2c(c1)CC(=O)N(CCCc1ccccc1)S2(=O)=O>>COc1ccc2c(c1)CCN(CCCc1ccccc1)S2(=O)=O,,C1CCOC1,,Cl,,val
US20050197359A1,Cc1c(/N=C2\OC[C@@H]3[C@H](O[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)CCN23)ccc(C#N)c1Cl>>Cc1c(/N=C2\OC[C@@H]3[C@H](O)CCN23)ccc(C#N)c1Cl,,C1CCOC1,,c1ccncc1,O=C([O-])O.[Na+],val
US20160168123A1,COC(=O)c1cncc(Cc2csc(-c3ccccc3)n2)c1>>O=C(O)c1cncc(Cc2csc(-c3ccccc3)n2)c1,,C1CCOC1,CO,CC(=O)O,[Na+].[OH-],val
US04876346,O=C1NCC(c2cccc(OCc3ccc4ccccc4n3)c2)O1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=S(=O)(NCC(O)c1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160244437A1,Cc1ccc(S(=O)(=O)N(C)C)cc1-c1cccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)c1.Cl>>Cc1ccc(S(=O)(=O)N(C)C)cc1-c1cccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)c1.Cl,,C1COCCO1,,CC#N,,val
US20130281449A1,CO.Cc1cc(O)cnc1C#N>>COc1cnc(C#N)c(C)c1,,C1CCOC1,CCOC(C)=O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080296538A1,O=C(CCCCC1CCSS1)OCc1ccc2ccc3cccc4ccc1c2c34>>O=C(CCCCC(S)CCS)OCc1ccc2ccc3cccc4ccc1c2c34,,O,,[BH4-].[Na+],,val
US20110190289A1,Fc1ccc(Oc2nn3ccnc3s2)cc1.O=C1CCC(=O)N1I>>Fc1ccc(Oc2nn3c(I)cnc3s2)cc1,,CN(C)C=O,,,,val
US20160257690A1,N#Cc1cnc2ccc(-c3c(-c4ccc(F)cc4)ncn3CC(F)F)nn12.NO>>N=C(NO)c1cnc2ccc(-c3c(-c4ccc(F)cc4)ncn3CC(F)F)nn12,,CCO,,Cl,,val
US20050096343A1,CC(=O)NC[C@H]1CN(c2ccc(N(C(=O)OCc3ccccc3)C3CN(C(=O)OCc4ccccc4)C3)c(F)c2)C(=O)O1>>CC(=O)NC[C@H]1CN(c2ccc(NC3CNC3)c(F)c2)C(=O)O1,[Pd],CO,,,,val
US20030216589A1,O=C(O)C=Cc1ccc([N+](=O)[O-])cc1F>>Nc1ccc(CCC(=O)O)c(F)c1,[Pd],CCOC(C)=O,,CCO,[H][H],val
US20140336106A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@]1(C)CO1.O=C(O)C(F)(F)F>>C[C@H](N)C(=O)N[C@@H](Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@]1(C)CO1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20150353499A1,O=C1CCCc2ccc(O)cc21.OCCc1ccccc1>>O=C1CCCc2ccc(OCCc3ccccc3)cc21,,C1CCOC1,O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040236109A1,COC(=O)c1ccc2c(c1)C(C)(c1ccccc1)CC(C)(C)N2C(C)=O>>CC(=O)N1c2ccc(C(=O)O)cc2C(C)(c2ccccc2)CC1(C)C,,C1COCCO1,O,[Na+].[OH-],,val
US20030130328A1,N#CCC(=O)Cc1ccc(OCCCN2CCOCC2)cc1.Nc1cc[nH]n1>>Nc1cc(Cc2ccc(OCCCN3CCOCC3)cc2)n[nH]1,,CCO,,NN,,val
US20140066533A1,CC[Zn]CC.O=C1C=CC=C/C1=C/NCCN/C=C1\C=CC=CC1=O>>O=C1C=CC=C/C1=C/NCCN/C=C1\C=CC=CC1=O.[Zn],,C1CCOC1,,,,val
US20150210682A1,CCCBr.COc1ccc(C=O)cc1O>>CCCOc1cc(C=O)ccc1OC,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20160024009A1,N#Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(-c2ccc(C(F)(F)F)cc2)c1>>NCc1cc(-c2ccc(C(F)(F)F)cc2)nc(-c2ccc(C(F)(F)F)cc2)c1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04372953,Cn1nnnc1Cl.NC(N)=S.O=C(CCCCl)c1ccccc1>>Cn1nnnc1SCCCC(=O)c1ccccc1,,CCO,,[Na+].[OH-],,val
US20090197864A1,C[C@@H](Oc1c(N)ncc2c(-c3ccc(C=O)s3)coc12)c1c(Cl)ccc(F)c1Cl>>C[C@@H](Oc1c(N)ncc2c(-c3ccc(CO)s3)coc12)c1c(Cl)ccc(F)c1Cl,,CO,,[BH4-].[Na+],,val
US20080113966A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3CCOC3)cnc21>>N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3CCOC3)cnc21,,C1COCCO1,,Cl,,val
US20150158865A1,CC(C)(C)OC(=O)N[C@@H]1CCCN(c2cnc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)C1.Cl>>Cl.NC(=O)c1ncc(N2CCC[C@@H](N)C2)nc1Nc1ccc(C(=O)N2CCOCC2)cc1,,C1COCCO1,,,,val
US20150158847A1,COc1ccc(COc2ccc(CNc3ccc(I)cc3N)cc2OC)cc1.N#CBr>>COc1ccc(COc2ccc(Cn3c(N)nc4cc(I)ccc43)cc2OC)cc1,,CO,ClCCl,[Na+].[OH-],,val
US20100137385A1,NC1CCc2c(F)cccc21.O=C=NCCCl>>O=C(NCCCl)NC1CCc2c(F)cccc21,,ClCCl,,CCN(CC)CC,,val
US20140350019A1,CC(C)OC(=O)CBr.COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(C)ccc(O)c1C>>COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(C)ccc(OCC(=O)OC(C)C)c1C,,CC(C)=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20160009683A1,CCOC(=O)C(F)(F)c1ccccc1OCCOC>>COCCOc1ccccc1C(F)(F)C(=O)O,,C1CCOC1,O,CO,[Li+].[OH-],val
US20100035883A1,CC(C)I.O=Cc1cnc[nH]1>>CC(C)n1cncc1C=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080027070A1,COc1ccc(C(=O)Cl)cc1.Nc1ccc(Cl)c(C(=O)O)c1>>COc1ccc(C(=O)Nc2ccc(Cl)c(C(=O)O)c2)cc1,,C1CCOC1,,,,val
US20110082133A1,COC(=O)c1ccc(CCn2c(C)cccc2=O)cc1.O=C1CCC(=O)N1Br>>COC(=O)c1ccc(CCn2c(C)c(Br)ccc2=O)cc1,,CC(=O)O,,CCOC(C)=O,O,val
US20100029621A1,O=[N+]([O-])c1cccc(S(=O)(=O)N2CCN(Cc3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)c1>>Nc1cccc(S(=O)(=O)N2CCN(Cc3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)c1,[Pd],CCOC(C)=O,,,,val
US20030149001A1,CC(C)(C)OC(=O)N1CCN(c2ccc(N)nc2)CC1(C)C.Cc1c(Br)c(=O)n(C2CCCC2)c2nc(S(C)=O)ncc12>>Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)C(C)(C)C4)cn3)ncc12,,Cc1ccccc1,,,,val
US20100305093A1,CCc1c(C(=O)O)ccc(F)c1F.OCCS>>CCc1c(C(=O)O)ccc(SCCO)c1F,,CS(C)=O,,Cl,[H-].[Na+],val
US20060079533A1,CC(C)(C)OC(=O)N1CCC(c2ccc(CN)cc2)C(OCc2ccc3ccccc3c2)C1.O=S(=O)(Cl)c1ccccc1>>CC(C)(C)OC(=O)N1CCC(c2ccc(C(N)S(=O)(=O)c3ccccc3)cc2)C(OCc2ccc3ccccc3c2)C1,,ClCCl,,CCN(CC)CC,,val
US20060189665A1,CCOC(=O)C(=O)Cl.Nc1ccc(Cl)c(C(F)(F)F)c1>>CCOC(=O)C(=O)Nc1ccc(Cl)c(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,,val
US20050256159A1,O=C(Cl)C1CCCCC1.O=C(c1ccc(OC(F)(F)F)cc1)C1CCNCC1>>O=C(c1ccc(OC(F)(F)F)cc1)C1CCN(C(=O)C2CCCCC2)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US09152045B2,C=C(CBr)C(=O)OC(C)(C)C.O=S(=O)(O)C(F)(F)CO.c1ccc([S+](c2ccccc2)c2ccccc2)cc1>>C=C(COCC(F)(F)S(=O)(=O)O)C(=O)OC(C)(C)C.c1ccc([S+](c2ccccc2)c2ccccc2)cc1,,CC#N,,[Na+].[OH-],,val
US04282365,Cc1ccc2c(c1)C(=O)OC2.[O-]c1ccccc1>>Cc1ccc(COc2ccccc2)c(C(=O)O)c1,,O,,Cl,,val
US20070185154A1,CC(C)(C)c1ccc(C=O)cc1.NCCc1cccc(C(F)(F)F)c1>>CC(C)(C)c1ccc(CNCCc2cccc(C(F)(F)F)c2)cc1,Cl,CO,,[BH4-].[Na+],,val
US04683239,O=Cc1ccc(O)cc1.O=[N+]([O-])c1ccc(F)cc1>>O=Cc1ccc(Oc2ccc([N+](=O)[O-])cc2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20100273764A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CC(C)(CO)c1ccc(F)nc1>>CC(C)(CO[Si](C)(C)C(C)(C)C)c1ccc(F)nc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080167305A1,CC(C)OB1OC(C)(C)C(C)(C)O1.FC(F)c1ccccc1Br>>CC1(C)OB(c2ccccc2C(F)F)OC1(C)C,,C1CCOC1,CCOC(C)=O,O,[Li]CCCC,val
US20160090374A1,CC(=O)N[C@H]1CCNC1.FC(F)(F)c1ccc2c(Cl)nc(Cl)nc2c1>>CC(=O)N[C@H]1CCN(c2nc(Cl)nc3cc(C(F)(F)F)ccc23)C1,,CCO,,,,val
US20060223801A1,COC(=O)[C@@H]1CC(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)CN1C(=O)OC(C)(C)C>>COC(=O)[C@@H]1CC(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)CN1,,C1COCCO1,Cl,,,val
US20070042909A1,CCOC(C)(OCC)OCC.COc1ccc2nc(NN)nnc2c1>>COc1ccc2c(c1)nnc1nnc(C)n12,,CCO,,,,val
US20130102778A1,Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1.Nc1ccc(F)cc1>>Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)Nc2ccc(F)cc2)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120142681A1,CC(=O)c1ccc2ncc(Cc3c(F)cc4c(cnn4C)c3F)n2n1.NNC(N)=O>>C/C(=N\NC(N)=O)c1ccc2ncc(Cc3c(F)cc4c(cnn4C)c3F)n2n1,,CO,,Cl,,val
US20130150343A1,CC(C)(c1nnc2ccc(O[C@@H]3CC[C@H](N)c4ccccc43)cn12)N1CCCC1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(C(C)(C)N5CCCC5)n4c3)c3ccccc32)cc1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20110112127A1,CC(C)[Si](C(C)C)(C(C)C)n1cc(I)c2cc(Cl)cnc21.COc1ccc(Cn2nc(NCc3ccc(F)cc3)cc2C=O)cc1>>COc1ccc(Cn2nc(NCc3ccc(F)cc3)cc2C(O)c2cn([Si](C(C)C)(C(C)C)C(C)C)c3ncc(Cl)cc23)cc1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20160102071A1,Cc1cc(O)ccc1Br.Cc1ccc(S(=O)(=O)OCCCS(C)(=O)=O)cc1>>Cc1cc(OCCCS(C)(=O)=O)ccc1Br,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20080070920A1,Cc1cc(C(C)(C)O[SiH2]C(C)(C)C)cc(C#N)n1>>Cc1cc(CO)cc(C#N)n1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140378447A1,Cc1cccc(-c2cnn(C)c2C(=O)O)n1.O=C(Cl)C(=O)Cl>>Cc1cccc(-c2cnn(C)c2C(=O)Cl)n1,,CN(C)C=O,,ClCCl,,val
US20120223635A1,Nc1ccccc1Br.O=C(Cl)c1cncc(Br)c1>>Brc1cncc(-c2nc3ccccc3o2)c1,[Cu]I,C1COCCO1,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US20120071461A1,COC(=O)c1ccc2c(c1)[C@H](N)CC2.O=C(Cl)c1cccc(F)c1Cl>>COC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccc(F)c1Cl)CC2,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20070249023A1,Nc1nc(C2O[C@H](CO)[C@@H](O)[C@@H]2O)nc2nc[nH]c12.Nc1ncnc2nc[nH]c12>>Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O,,O,,,,val
US20050267096A1,Brc1cccc2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cc12.CCN1CC(=O)OC[C@@H]1C>>CCN1CC(O)(c2cccc3nn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cc23)OC[C@@H]1C,,C1CCOC1,,[Li]C(C)(C)C,,val
US05945434,C1CC2(CCN1)OCCO2.Fc1ccc(CCl)cc1>>Fc1ccc(CN2CCC3(CC2)OCCO3)cc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20080132507A1,COC(=O)C(Nc1ccc(C(=N)N)cc1)c1cc(OC)c(OC)cc1F.Cl>>COc1cc(F)c(C(Nc2ccc(C(=N)N)cc2)C(=O)O)cc1OC.Cl,,C1CCOC1,CO,CCOCC,[Na+].[OH-],val
US20020004511A1,CC(=O)CN.O=C(Cl)c1cc2nccc(Cl)c2s1>>CC(=O)CNC(=O)c1cc2nccc(Cl)c2s1,,ClCCl,,CCN(CC)CC,Cl,val
US20060135572A1,CC(OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1ccccc1-c1ccc(C#N)cc1.O=C(O)CC(O)(CC(=O)O)C(=O)O.[OH-]>>CC(OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1ccccc1-c1ccc(C(=O)O)cc1,,OCCO,,O,,val
US20150065550A1,CCC[Mg]Br.O=CCc1ccccc1Br>>CCC(O)Cc1ccccc1Br,,C1CCOC1,,,,val
US20100075952A1,COCC(=O)Cl.Nc1cc2c(cc1F)CC(=O)N2>>COCC(=O)Nc1cc2c(cc1F)CC(=O)N2,,C1CCOC1,,c1ccncc1,,val
US20150045340A1,CC(C)(C)OC(=O)NC(=N)c1ncc(O)cc1O.CS(=O)(=O)OCCON1C(=O)c2ccccc2C1=O>>CC(C)(C)OC(=O)NC(=N)c1ncc(OCCON2C(=O)c3ccccc3C2=O)cc1O,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20140315960A1,CN(CCO)c1ccccc1.O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl>>CN(CCOC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl)c1ccccc1,CN(C)c1ccncc1,CCOC(C)=O,,ClCCl,,val
US05739162,NCC(=O)Nc1ccccc1C(=O)c1ccccc1.Nc1cccc(Br)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(CNC(=O)Nc1cccc(Br)c1)Nc1ccccc1C(=O)c1ccccc1,,C1CCOC1,,Br,CCN(CC)CC,val
US20100076026A1,O=C=NC1CCCCC1.c1ccc(-n2nc3ccccc3c2NC2CCCCC2)cc1>>O=C(NC1CCCCC1)N(c1c2ccccc2nn1-c1ccccc1)C1CCCCC1,,Cc1ccccc1,,,,val
US20040176395A1,COC(=O)c1ccc(CN2CC(=O)N(C)C2=O)cc1>>CN1C(=O)CN(Cc2ccc(C(=O)O)cc2)C1=O,,CO,,Cl,,val
US06303556B1,CC(=O)CC/C=C(\C)CCC=C(C)C>>CC(C)CCCC(C)CCCC(C)O,[Ru],CO,,,,val
US05232898,C#CCN1C(=O)COc2cc(F)c(NC(=O)C=C(CC)NC(=O)OCC)cc21>>C#CCN1C(=O)COc2cc(F)c(-n3c(=O)cc(CC)[nH]c3=O)cc21,,CO,O,Cl,C[O-].[Na+],val
US20100249163A1,CC(C)(C)OC(=O)N1CC[C@](O)(c2ccc(F)c(F)c2)[C@@H](C(=O)N(Cc2cccc(Cl)c2Cl)C2CC2)C1>>O=C(C1CNCCC1(O)c1ccc(F)c(F)c1)N(Cc1cccc(Cl)c1Cl)C1CC1,,ClCCl,,Cl,,val
US20090018132A1,Cc1cc(C(C)OCC2(c3ccc(F)cc3)CCN(C(=O)OC(C)(C)C)CC2)c2[nH]ncc2c1>>Cc1cc(C(C)OCC2(c3ccc(F)cc3)CCNCC2)c2[nH]ncc2c1,,O=C(O)C(F)(F)F,,,,val
US20110183985A1,CC(=O)c1cc(Cl)c2cccnc2c1N1CCNCC1.COCC(=O)Cl>>COCC(=O)N1CCN(c2c(C(C)=O)cc(Cl)c3cccnc23)CC1,,ClCCl,ClCCl,CCN(CC)CC,,val
US20120220568A1,C1CCNC1.O=Cc1c(F)cc(Br)cc1F>>Fc1cc(Br)cc(F)c1CN1CCCC1,,ClCCl,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04599333,CC(C)(N)CN(Cc1ccccc1)Cc1ccccc1.Cc1ccccc1OCC1CO1>>Cc1ccccc1OCC(O)CNC(C)(C)CN(Cc1ccccc1)Cc1ccccc1,,CCO,,,,val
US20110190269A1,COc1cc(Br)ccc1-n1cnc(C)c1.Cc1cc(-c2ccc(F)cc2C)c2nc(N)nn2c1>>COc1cc(Nc2nc3c(-c4ccc(F)cc4C)cc(C)cn3n2)ccc1-n1cnc(C)c1,,CO,ClCCl,,,val
US20050256140A1,CC(C)(C)OC(=O)Nc1ccoc1C(N)=O>>O=c1[nH]cnc2ccoc12,,CN(C)C=O,,ClCCl,,val
US06809097B1,COc1cc2c(Nc3ccc(Cl)cc3F)ccnc2cc1O.OCCBr>>COc1cc2c(Nc3ccc(Cl)cc3F)ccnc2cc1OCCO,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20160002188A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(Br)cc2)CC1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C(c1ccc(Br)cc1)N1CCNCC1,,ClCCl,,,,val
US20090076004A1,CCOC(=O)CN(C)Cc1c(C(=O)OCC)n(-c2ccc(OC(C)C)cc2)c2ccc(-c3ccc(C(C)(C)C)cc3)cc12>>CCOC(=O)CN(C)Cc1c(C(=O)O)n(-c2ccc(OC(C)C)cc2)c2ccc(-c3ccc(C(C)(C)C)cc3)cc12,,C1COCCO1,,Cl,[Na+].[OH-],val
US20150133432A1,CCC1(C)CN(Cc2cc(-c3ccc(O)cc3)nc3c2c(C)nn3C2CCCCO2)C(C)(C)CN1C(=O)OC(C)(C)C>>CCC1(C)CN(Cc2cc(-c3ccc(O)cc3)nc3[nH]nc(C)c23)C(C)(C)CN1,,C1CCOC1,,Cl,,val
US20030083335A1,COC(=O)[C@H](C)N(Cc1ccc(F)cc1)C(=O)[C@@H](C)NC(=O)OC(C)(C)C>>C[C@H]1NC(=O)[C@H](C)N(Cc2ccc(F)cc2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060005321A1,NS(=O)(=O)CCNc1ccc([N+](=O)[O-])cc1>>Nc1ccc(NCCS(N)(=O)=O)cc1,,CCO,,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20060106073A1,C[C@@H](CCCCOCc1ccccc1)C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1>>C[C@H](CO)CCCCOCc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06235771B1,CCCOc1ccc2oc(OB([O-])[O-])cc2c1.CN(Cc1ccc(NC(=O)C2=Cc3cc(Br)ccc3S(=O)(=O)CC2)cc1)C1CCOCC1>>CCCOc1ccc2oc(-c3ccc4c(c3)C=C(C(=O)Nc3ccc(CN(C)C5CCOCC5)cc3)CCS4(=O)=O)cc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,CCO,O=C([O-])[O-].[K+].[K+],val
US05877196,CS(=O)(=O)Cl.Cc1ccc(S(=O)(=O)NCCCCSc2ccc(N)cc2)cc1>>Cc1ccc(S(=O)(=O)NCCCCSc2ccc(NS(C)(=O)=O)cc2)cc1,,c1ccncc1,,,,val
US20060281700A1,CC(C)(C)OC(=O)NC1CCN(c2ncnc(N)c2C=O)C1.CON.O=C(O)C(F)(F)F>>CON=Cc1c(N)ncnc1N1CCC(N)C1.O=C(O)C(F)(F)F,,CO,,Cl,ClCCl,val
US04121921,COC(=O)N=C(N)OC.O=C=Nc1ccc(Cl)cc1>>COC(=O)N=C(NC(=O)Nc1ccc(Cl)cc1)OC,,ClCCl,,,,val
US20090170907A1,ClCc1cscn1.N#Cc1ccc(NCC(F)(F)F)cc1Cl>>N#Cc1ccc(N(Cc2cscn2)CC(F)(F)F)cc1Cl,,CC#N,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US05206240,CC(=O)NN1CCC2(CC1)Oc1ccc(S(C)(=O)=O)cc1C(=O)C2C.Cl>>CC1C(=O)c2cc(S(C)(=O)=O)ccc2OC12CCNCC2.Cl,,CO,,,,val
US20140057899A1,[N-]=[N+]=NC1CCc2c(-c3cnc4ccccc4c3)c3c(N)ncnc3n2C1>>Nc1ncnc2c1c(-c1cnc3ccccc3c1)c1n2CC(N)CC1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04612321,CCC(N)=S.COc1ccc(C(=O)C(Br)c2cccnc2)cc1>>CCc1nc(-c2ccc(OC)cc2)c(-c2cccnc2)s1,,CC#N,,CCN(CC)CC,,val
US20130331378A1,COC(=O)c1cccc(C=O)n1.C[Si](C)(C)c1c(Cl)ccc2c(Br)c(N3CCOCC3)nn12>>COC(=O)c1cccc(C(O)c2c(N3CCOCC3)nn3c([Si](C)(C)C)c(Cl)ccc23)n1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US06251925B1,CC(C)(C)OC(=O)N(CC=O)C[C@H](O[Si](C)(C)C(C)(C)C)c1cccc(Cl)c1.COC(=O)c1cc(-c2cccc(N)c2)cc2c1OCC2>>COC(=O)c1cc(-c2cccc(NCCN(C[C@H](O[Si](C)(C)C(C)(C)C)c3cccc(Cl)c3)C(=O)OC(C)(C)C)c2)cc2c1OCC2,,CCCCCC,CCOC(C)=O,,,val
US20070259851A1,ClCCCl.O=C1Nc2c(F)cccc2CCN1C1CCN(Cc2ccccc2)CC1>>Cl.O=C1Nc2c(F)cccc2CCN1C1CCNCC1,,ClCCCl,,CC(Cl)OC(=O)Cl,,val
US20140323464A1,COc1ccc([N+](=O)[O-])cc1N.Fc1cnc(Cl)nc1Nc1ccccc1>>COc1ccc([N+](=O)[O-])cc1Nc1ncc(F)c(Nc2ccccc2)n1,,CC(C)O,,O=C(O)C(F)(F)F,,val
US05173489,O=C1c2ncccc2-c2cccnc21>>c1cnc2c(c1)-c1cccnc1C2,,OCCOCCO,,NN,,val
US20080090822A1,CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3N3CCCCC3)CC2)c(F)c1>>CC(O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3N3CCCCC3)CC2)c(F)c1,,CO,,[BH4-].[Na+],,val
US04992431,C=CCO.CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1>>C=CCOCC1=C(C(=O)O)N2C(=O)C(N)[C@H]2SC1,,CCN(CC)CC,,FB(F)F,,val
US20090298896A1,CCCCCCc1nc(-c2ccc(C)cc2)sc1CCC(=O)c1ccc(CCC(=O)OC)c(C)c1>>CCCCCCc1nc(-c2ccc(C)cc2)sc1CCC(=O)c1ccc(CCC(=O)O)c(C)c1,,CCO,O,Cl,[Li+].[OH-],val
US20070027173A1,O=C(O)c1cccc(Cl)c1Br.O=C1OC2(CCNCC2)c2c(Cl)cccc21>>O=C1CCN(Cc2ccccc2)CC1,[Pd],,,CO,Cl,val
US20140187553A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)c1ccc2c(c1)c(I)cn2S(=O)(=O)c1ccc(C)cc1>>COC(=O)c1ccc2c(c1)c(B1OC(C)(C)C(C)(C)O1)cn2S(=O)(=O)c1ccc(C)cc1,,CN(C)C=O,,ClCCl,CC(=O)[O-].[K+],val
US20090181950A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc2cc(Br)cc(N3CCNCC3)c2n1>>Cc1ccc2cc(Br)cc(N3CCN(C(=O)OC(C)(C)C)CC3)c2n1,CN(C)c1ccncc1,CC#N,,CCN(CC)CC,,val
US20150232445A1,CC(=O)N1c2ccc(-c3cnn(C4CCN(C(=O)OC(C)(C)C)CC4)c3)c(Oc3ccccc3F)c2CC[C@@H]1C>>CC(=O)N1c2ccc(-c3cnn(C4CCNCC4)c3)c(Oc3ccccc3F)c2CC[C@@H]1C,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20140163219A1,CC(C)C(=O)Cl.NC(N)=S>>CC(C)C(=O)NC(N)=S,,Cc1ccccc1,,,,val
US20080207654A1,BrCc1ccccc1.CCCCc1nc(CO)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1>>CCCCc1nc(CO)n(Cc2ccccc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1,,CC(=O)N(C)C,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150105366A1,COc1nc2ccc(C(O)c3cnc(C)n3C)cc2c(Cl)c1Cc1ccc(C(F)(F)F)nc1.Cc1ccc(C(=O)c2cnnn2C)c(C)n1>>COc1nc2ccc(C(O)(c3ccc(C)nc3C)c3cnnn3C)cc2c(Cl)c1Cc1ccc(C(F)(F)F)nc1,,C1CCOC1,,[Li]CCCC,,val
US20080214533A1,CS(=O)(=O)O.Cc1nc(C(=O)Nc2ccc(N(C#N)CCO[Si](C)(C)C(C)(C)C)cc2)c(C(=O)Nc2ccc(Cl)cn2)s1>>CS(=O)(=O)O.Cc1nc(C(=O)Nc2ccc(N3CCOC3=N)cc2)c(C(=O)Nc2ccc(Cl)cn2)s1,,CC#N,,,,val
US20090042967A1,CC(=O)Nc1ccc(C#N)c(Cl)c1F>>N#Cc1ccc(N)c(F)c1Cl,,CCO,,O=C([O-])O.[Na+],,val
US20050267093A1,CC1CCN(CCOc2ccc([N+](=O)[O-])cc2)CC1>>CC1CCN(CCOc2ccc(N)cc2)CC1,[Pd],CO,,[H][H],,val
US20030216406A1,CCNc1nc(Cl)ncc1C#N.Nc1ccc(S(=O)(=O)F)cc1>>CCNc1nc(Nc2ccc(S(=O)(=O)F)cc2)ncc1C#N,,CCC(C)O,,,,val
US04540703,COC(=O)CCCCc1nnnn1-c1ccccc1>>O=C(O)CCCCc1nnnn1-c1ccccc1,,O,,Cl,,val
US20100120846A1,CC(=O)OC(C)=O.Nc1cc2ccccc2cn1>>CC(=O)Nc1cc2ccccc2cn1,,ClCCl,,CCN(CC)CC,,val
US20140142307A1,BrCc1cc2ccc3cccc4ccc(c1)c2c34.BrCc1cnc2ccccc2n1.Clc1nc[nH]c1Cl>>Clc1c(Cl)[n+](Cc2cc3ccc4cccc5ccc(c2)c3c45)cn1Cc1cnc2ccccc2n1.[Br-],,CC#N,,[K+].[OH-],,val
US20100280065A1,CC(C)n1cnc2c([N+](=O)[O-])cc([N+](=O)[O-])nc21.NCc1ccccc1>>CC(C)n1cnc2c(NCc3ccccc3)cc([N+](=O)[O-])nc21,,CN(C)C=O,,CCN(CC)CC,CCOCC,val
US20130064770A1,CC(C)(C)OC(=O)N1CCN(CCCNc2nc(-c3ccccc3)cs2)CC1>>c1ccc(-c2csc(NCCCN3CCNCC3)n2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060264429A1,CC(Cl)Cl.O=Cc1ccc2c(c1)NC(=O)CO2.c1cnc2c(N3CCNCC3)cccc2c1>>Cl.O=C1COc2ccc(CN3CCN(c4cccc5cccnc45)CC3)cc2N1,,O,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20070161648A1,COc1ccc2[nH]c(-c3ccc([N+](=O)[O-])c4c3C(=O)NC4)cc2c1>>COc1ccc2[nH]c(-c3ccc(N)c4c3C(=O)NC4)cc2c1,[Pd],CCO,,,,val
US20110028450A1,COc1cc2c(cc1F)-c1cc3c(n1CC2)C(=O)N(C(C)(C)C)CCCC3.O=C1CCC(=O)N1Br>>COc1cc2c(cc1F)-c1c(Br)c3c(n1CC2)C(=O)N(C(C)(C)C)CCCC3,,CN(C)C=O,,O,,val
US04992433,CCOC(=O)c1ccc(OCC2(O)CCN(c3ccc(Cl)nn3)CC2)cc1>>CCOC(=O)c1ccc(OCC2=CCN(c3ccc(Cl)nn3)CC2)cc1,,CCOC(C)=O,,O=S(Cl)Cl,,val
US20140163000A1,CN1CC=C(c2c(F)cncc2NC(=O)OC(C)(C)C)CC1>>CN1CC=C(c2c(N)cncc2F)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090253758A1,CC(C)(C)[Si](C)(C)Cl.Cc1c(N[C@@H](C(=O)NNC(=O)c2ccc(CO[Si](C)(C)C(C)(C)C)cc2)[C@H](C)O)ccc(C#N)c1Cl>>Cc1c(N[C@@H](C(=O)NNC(=O)c2ccc(CO[Si](C)(C)C(C)(C)C)cc2)[C@H](C)O[Si](C)(C)C(C)(C)C)ccc(C#N)c1Cl,,CN(C)C=O,,O,c1c[nH]cn1,val
US04476307,C1COCCN1.CN(C)C=C1C(=O)N(c2cccc(Cl)c2)c2ccccc21>>O=C1C(=CN2CCOCC2)c2ccccc2N1c1cccc(Cl)c1,,CCO,,,,val
US05679696,COC(=O)c1ccc(SC)c(N)c1.O=N[O-]>>COC(=O)c1ccc(SC)c(O)c1,,O,,Cl,,val
US04514419,CNN.S=C=Nc1ccc(Cl)cc1>>CN(N)C(=S)Nc1ccc(Cl)cc1,,CCO,,,,val
US05200550,COC(=O)c1ccc(O)cc1O.COc1ccc(C(=O)Cl)cc1C12CC3CC(CC(C3)C1)C2>>COC(=O)c1ccc(OC(=O)c2ccc(OC)c(C34CC5CC(CC(C5)C3)C4)c2)cc1O,,C1CCOC1,,CCN(CC)CC,O,val
US20060235033A1,COc1cc2nccc(Oc3ccc(N)c(C)c3)c2cc1OC.C[C@@H](N)c1cccc(Br)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)N[C@H](C)c4cccc(Br)c4)c(C)c3)c2cc1OC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20130059834A1,C1CCOC1.Cn1nc(-c2cnc3c(n2)c(C(=O)[O-])cn3C(c2ccccc2)(c2ccccc2)c2ccccc2)c2cc(O[Si](C)(C)C(C)(C)C)ccc21>>COC(=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c2ncc(-c3nn(C)c4ccc(O)cc34)nc12,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US06486190B1,Cc1cc(N)c(N)c(C)c1[N+](=O)[O-].N#CBr>>Cc1cc2nc(N)[nH]c2c(C)c1[N+](=O)[O-],,CO,,,,val
US20070259856A1,CNCCN.ClCCl.N#Cc1ccccc1S(=O)(=O)Cl>>CN(CCCN)S(=O)(=O)c1ccccc1C#N,,ClCCl,,CCN(CC)CC,,val
US20150175594A1,CC1(C)CC(=O)OC(=O)C1.Cc1noc(-c2c(NC(=O)CC(C)(C)C(=O)O)sc3c2CCCC3)n1>>Cc1noc(-c2c(NC(=O)CC(C)(C)CC(=O)O)sc3c2CCCC3)n1,CN(C)c1ccncc1,COC(C)(C)C,,,,val
US20090048291A1,CS(=O)(=O)Cl.CS(=O)(=O)c1ccc(NC(=O)CC2CCN(CCN(c3ccccc3)C3CCNCC3)CC2)cc1>>CS(=O)(=O)c1ccc(NC(=O)CC2CCN(CCN(c3ccccc3)C3CCN(S(C)(=O)=O)CC3)CC2)cc1,,CC#N,,,,val
US05712267,COc1ccc(CS[C@H]2C[C@@H](C(=O)O)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1.N[C@H]1CCNC1>>COc1ccc(CS[C@H]2C[C@@H](C(=O)N3CC[C@H](N)C3)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1,,CC#N,,,,val
US20160024004A1,CC[C@@H](C)N.O=C(O)c1cc(S(=O)(=O)Cl)ccc1F>>CC[C@@H](C)NS(=O)(=O)c1ccc(F)c(C(=O)O)c1,,ClCCl,,CCN(CC)CC,,val
US20060276464A1,O=C([C@@H]1CCCN1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1.O=CC1CCCCC1>>O=C([C@@H]1CCCN1CC1CCCCC1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1,,CO,,,,val
US20050171180A1,CCC(CC)C(NS(=O)(=O)c1ccc(Cl)s1)c1ccnn1-c1ccc(OC)cc1>>CCC(CC)C(NS(=O)(=O)c1ccc(Cl)s1)c1ccnn1-c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,O,val
US20060172983A1,COC(=O)C(C)Oc1ccc([N+](=O)[O-])cc1>>CC(Oc1ccc([N+](=O)[O-])cc1)C(=O)O,,Cl,,,,val
US03953497,CNC(=O)c1c(I)c(NC(=O)COC)c(I)c(C(=O)O)c1I.O=S(Cl)Cl>>CNC(=O)c1c(I)c(NC(=O)COC)c(I)c(C(=O)Cl)c1I,,CC(=O)N(C)C,,,,val
US20150284411A1,C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@H]3[C@@H]2OC[C@H]3O)nc2nc(N3CCC(c4ccccc4)CC3)c(Cl)cc21>>O[C@@H]1CO[C@@H]2[C@H](Oc3nc4nc(N5CCC(c6ccccc6)CC5)c(Cl)cc4[nH]3)CO[C@@H]21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120059014A1,CC(C)c1noc(N2CCC([C@H](C)CCOc3cc(N4C[C@H](NC(=O)OC(C)(C)C)[C@@H](c5cc(F)ccc5F)C4)ncn3)CC2)n1>>CC(C)c1noc(N2CCC([C@H](C)CCOc3cc(N4C[C@H](N)[C@@H](c5cc(F)ccc5F)C4)ncn3)CC2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05239080,CN.O=C(O)CCc1nc(-c2ccc(Cl)cc2)co1>>CNC(=O)CCc1nc(-c2ccc(Cl)cc2)co1,,C1CCOC1,O,CCN(CC)CC,CCOC(=O)Cl,val
US20140024666A1,CCCCNC(=O)NCc1ccccc1.O=C(Cl)CC(=O)Cl>>CCCCN1C(=O)CC(=O)N(Cc2ccccc2)C1=O,,ClCCl,,,,val
US20160108056A1,N#Cc1cc(-c2ccc(F)cc2F)cc([N+](=O)[O-])c1>>N#Cc1cc(N)cc(-c2ccc(F)cc2F)c1,[Zn],CO,O,[Cl-].[NH4+],,val
US06921763B2,CC(C)(C)OC(=O)N1CCC(n2nc(I)c3c(N)ncnc32)C1.Cc1cc(C)c2oc(Nc3ccc(B4OC(C)(C)C(C)(C)O4)cc3)nc2c1>>Cc1cc(C)c2oc(Nc3ccc(-c4nn(C5CCN(C(=O)OC(C)(C)C)C5)c5ncnc(N)c45)cc3)nc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20080242683A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)O[C@@H]1C[C@@H](CN)N(C(=O)OCc2ccccc2)C1>>CC(C)(C)OC(=O)NC[C@@H]1C[C@@H](OC(C)(C)C)CN1C(=O)OCc1ccccc1,,ClCCl,,,,val
US20060004017A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1cc2c(Oc3ccc4[nH]c(C)c(C)c4c3)ncnc2cc1OCc1ccccc1>>COc1cc2c(Oc3ccc4c(c3)c(C)c(C)n4C(=O)OC(C)(C)C)ncnc2cc1OCc1ccccc1,CN(C)c1ccncc1,CC#N,,,,val
US20090181942A1,CCOC(=O)C[C@@H]1O[C@@H](c2cccc(OC)c2Cl)c2cc(Cl)ccc2-n2c1nnc2C(F)(F)F>>COc1cccc([C@@H]2O[C@@H](CC(=O)O)c3nnc(C(F)(F)F)n3-c3ccc(Cl)cc32)c1Cl,,C1COCCO1,CCOC(C)=O,Cl,,val
US04978753,CCC(=O)OC(=O)CC.O=c1ccn2c(n1)C(O)N=C(c1ccccc1Cl)c1cc(Cl)ccc1-2>>CCC(=O)O.O=c1ccn2c(n1)C(O)N=C(c1ccccc1Cl)c1cc(Cl)ccc1-2,,c1ccncc1,,,,val
US20090163469A1,COC(=O)C(C)(C)CO.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)C(C)(C)COS(=O)(=O)C(F)(F)F,,ClCCl,,Cc1cccc(C)n1,,val
US20090111825A1,CC(C)(C)OC(=O)N1[C@@H](c2cc(-c3csc(Cl)c3)on2)C[C@H]2C[C@H]21>>Clc1cc(-c2cc([C@H]3C[C@H]4C[C@H]4N3)no2)cs1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04732979,C1CCNC1.O=C1CCc2cc(F)ccc2C1>>O=C1CNC2=C(CCc3cc(F)ccc32)C1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150111891A1,CC(C)(C)C(=O)Cl.Cc1cc2ccccc2c(Cl)c1C(CO)OC(C)(C)C(F)(F)F>>Cc1cc2ccccc2c(Cl)c1C(COC(=O)C(C)(C)C)OC(C)(C)C(F)(F)F,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20060231832A1,BrBr.CCCCCCCOc1ccc(-c2nc3ccccc3s2)cc1>>CCCCCCCOc1ccc(-c2nc3ccc(Br)cc3s2)cc1,,CC(=O)O,,,,val
US20100029782A1,CCOC(=O)C(C)(C)Cc1ccc(OC)cc1>>COc1ccc(CC(C)(C)C(=O)O)cc1,,C1CCOC1,O,Cl,CC(C)(C)[O-].[K+],val
US04380640,CC1(C)CC(=O)C(Br)C(=O)C1.CNC(N)=S>>CNc1nc2c(s1)C(=O)CC(C)(C)C2,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20030055085A1,COc1cc(C(N)=O)nc(C(N)=O)c1>>COc1cc(C#N)nc(C#N)c1,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US20090298811A1,CC[C@H](C)[C@H](N)C(N)=O.Cl.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.O=c1[nH]c2ccccc2n1CCN1CCOCC1>>CC[C@H](C)[C@H](NC(=O)n1c(=O)n(CCN2CCOCC2)c2ccccc21)C(N)=O.Cl,,ClCCl,,CCN(CC)CC,,val
US20100016272A1,O=C(O)C=Cc1ccc(Br)s1.OB(O)c1ccccc1F>>O=C(O)C=Cc1ccc(-c2ccccc2F)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20100184739A1,CC(C)(C)C(=O)Cl.Nc1ccc(Br)c([N+](=O)[O-])c1>>CC(C)(C)C(=O)Nc1ccc(Br)c([N+](=O)[O-])c1,,ClCCl,,CCN(CC)CC,,val
US20150353548A1,CC(C)(C)OC(=O)N1CCC2(CCNC2=O)CC1.Cc1ccc(C)n1-c1ncc(Br)c(Cl)c1Cl>>Cc1ccc(C)n1-c1ncc(Br)c(N2CCC3(CCNC3=O)CC2)c1Cl,,CN1CCCC1=O,,CCN(CC)CC,,val
US05834506,CC(C)(C)NS(=O)(=O)Cl.Cc1ccc(S(=O)(=O)Sc2cc(C)c(O)cc2C(C)(C)C)cc1>>Cc1ccc(S(=O)(=O)Sc2cc(C)c(OS(=O)(=O)NC(C)(C)C)cc2C(C)(C)C)cc1,,CCOCC,,CCN(CC)CC,,val
US20150105373A1,CC(C)(C)OC(=O)NC(C#N)c1ccc(OC(F)(F)F)cc1.OO>>CC(C)(C)OC(=O)NC(C(N)=O)c1ccc(OC(F)(F)F)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070225267A1,CC(C)(C)CO[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](C=O)CO1.O=[N+]([O-])CCc1cc(F)cc(Cl)c1>>CC(C)(C)CO[C@H]1CN(C(=O)OC(C)(C)C)[C@@H]([C@@H](O)[C@H](Cc2cc(F)cc(Cl)c2)[N+](=O)[O-])CO1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04058642,CCOC(=O)[C@H](Cc1ccc(C)c(OC)c1)NC(=O)c1ccccc1>>COc1cc(CC(CO)NCc2ccccc2)ccc1C,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20090062358A1,CC(C)(C)OC(=O)NN.O=Cc1cc(F)cc(F)c1>>CC(C)(C)OC(=O)NN=Cc1cc(F)cc(F)c1,,CCOC(C)=O,,,,val
US20080058320A1,CC(C)C(COCc1ccccc1)CC1COC(C)(C)N1C(=O)OC(C)(C)C>>CC(C)C(CO)CC1COC(C)(C)N1C(=O)OC(C)(C)C,[Pd],C1CCOC1,,,,val
US20140228343A1,Clc1cncc(Cl)n1.NCC(O)CN1CCc2ccccc2C1>>OC(CNc1cncc(Cl)n1)CN1CCc2ccccc2C1,,CC(C)O,,,,val
US20150291593A1,C[Mg]I.Cc1ccn2cc(C=O)n(-c3ccccc3)c(=O)c12>>Cc1ccn2cc(C(C)O)n(-c3ccccc3)c(=O)c12,,C1CCOC1,,CCOCC,,val
US05070089,CSC(=S)N1CCN(Cc2cccc(O)c2O)CC1.Cl>>CSC(=S)N1CCN(Cc2cccc(O)c2O)CC1.Cl,,CC(C)=O,,CCOCC,,val
US20100324028A1,COc1cc(C(=O)N2CCc3c2ccc(F)c3F)cc(Cl)n1.O=c1[nH]c2ncccc2n1C1CCNCC1>>COc1cc(C(=O)N2CCc3c2ccc(F)c3F)cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)n1,,CN1CCCC1=O,,,,val
US20030130261A1,COc1ccc(O)c(C(=O)C2CC=CC2)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc(OS(=O)(=O)C(F)(F)F)c(C(=O)C2CC=CC2)c1,,ClCCl,,Cl,c1ccncc1,val
US20090012077A1,CC(C)(C)OC(=O)N1CCc2[nH]c3c(OCCN4CCCCC4)cccc3c2C1>>c1cc(OCCN2CCCCC2)c2[nH]c3c(c2c1)CNCC3,,CO,,Cl,,val
US20120225062A1,COC(=O)c1ccc(F)c(-c2c(F)cc(O)cc2F)n1.N#CC1(CBr)CCOCC1>>COC(=O)c1ccc(F)c(-c2c(F)cc(OCC3(C#N)CCOCC3)cc2F)n1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20120022061A1,CI.CN(C)C=O.O=[N+]([O-])c1cccc2c(Br)c(O)c(O)cc12>>COc1cc2c([N+](=O)[O-])cccc2c(Br)c1OC,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04704459,CCOC(=O)c1cn(-c2ccc(F)cc2F)c2nc(S(=O)(=O)c3ccccc3)c(F)cc2c1=O>>O=C(O)c1cn(-c2ccc(F)cc2F)c2nc(S(=O)(=O)c3ccccc3)c(F)cc2c1=O,,C1COCCO1,,Cl,,val
US20050038056A1,C=C1CC(=O)O1.NC(=O)NCc1c(F)cccc1C(F)(F)F>>Cc1cc(=O)[nH]c(=O)n1Cc1c(F)cccc1C(F)(F)F,,CC#N,O,C[Si](C)(C)Cl,[I-].[Na+],val
US07271186B1,C1CCOC1.C1COCN1.CC1(O)CCC2CC1(O)C2(C)C.CCCCCC.COB(OC)OC.C[Si](C)(C)Cl.[Li]CCCC>>CC1(C)COC(c2cccc(B([O-])[O-])c2)=N1.CC1(O)CCC2CC1(O)C2(C)C,,C1CCOC1,CCOCC,,,val
US20160024044A1,N#CCc1ccc(Br)cc1.O=Cc1ccccc1>>N#CC(c1ccc(Br)cc1)C(O)c1ccccc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20110092561A1,CCOC(=O)Cc1ccc(N2C(=O)c3c(c(OC(F)F)c4ccccc4c3OC(C)C)C2=O)cc1>>CC(C)Oc1c2c(c(OC(F)F)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)cc1)C2=O,,O,,CC(=O)O,Cl,val
US20120094958A1,CCOP(=O)(CNC(=O)c1ccc2cccc(-c3cccc4ccccc34)c2n1)OCC>>O=C(NCP(=O)(O)O)c1ccc2cccc(-c3cccc4ccccc34)c2n1,,ClCCl,,C[Si](C)(C)Br,,val
US20080214641A1,COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(Cl)cc3)c2)[C@H](C)N)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(Cl)cc3)c2)[C@H](C)NC(=O)C(F)(F)F)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080214601A1,Cl.O=C(N[C@@H]1CN2CCC1CC2)c1cccc2oc(C3CCCCC3)nc12>>Cl.O=C(N[C@@H]1CN2CCC1CC2)c1cccc2oc(C3CCCCC3)nc12,,CCOCC,CO,,,val
US20100190766A1,C#Cc1ccc(N)cc1.O=C(Cl)OCC1c2ccccc2-c2ccccc21>>C#Cc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06465455B1,CN(C)c1cccc(C(=O)Nc2cc(N)c(Cl)cc2F)c1.COc1ccc(C(=O)Cl)cc1OC>>COc1ccc(C(=O)Nc2cc(NC(=O)c3cccc(N(C)C)c3)c(F)cc2Cl)cc1OC,,c1ccncc1,,,,val
US20130211075A1,CCOC(=O)c1cnn(-c2ncc(Cl)cc2Cl)c1C>>Cc1c(C(=O)O)cnn1-c1ncc(Cl)cc1Cl,,O,,[Na+].[OH-],,val
US20160229816A1,CCOC(OCC)c1cccc(C=O)c1>>CCOC(OCC)c1cccc(CO)c1,,CCO,,O,[BH4-].[Na+],val
US07572811B2,Clc1ccc(Br)cn1.OCc1ccc(C2CCCCC2)c(C(F)(F)F)c1>>FC(F)(F)c1cc(COc2ccc(Br)cn2)ccc1C1CCCCC1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US04948796,BrC(Br)(Br)Br.OC/C=C/c1cccc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)c1>>BrC/C=C/c1cccc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)c1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070249607A1,CC(C)(C)OC(=O)N1CCC(CO)(c2ccccc2)CC1.COc1ccc([N+](=O)[O-])cc1CBr>>COc1ccc([N+](=O)[O-])cc1COCC1(c2ccccc2)CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,O,[H-].[Na+],,val
US20060122195A1,CO.O=S(=O)(Nc1ncc(Cl)nc1Cl)c1cccc(Cl)c1Cl>>COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl,,CO,,C[O-].[Na+],,val
US06429212B1,C[C@@H](N)c1ccccc1.O=C1OC(=O)c2c1cccc2[N+](=O)[O-]>>C[C@H](c1ccccc1)N1C(=O)c2cccc([N+](=O)[O-])c2C1=O,,ClC(Cl)Cl,,,,val
US20110183973A1,Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12.O=C(O)C1CN(C(=O)OCc2ccccc2)CC1O>>O=C(Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12)C1CN(C(=O)OCc2ccccc2)CC1O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090093517A1,COc1cc2ccncc2cc1OC.C[Si](C)(C)C#N.O=C(Cl)c1ccccc1>>COc1cc2c(cc1OC)C(C#N)N(C(=O)c1ccccc1)C=C2,,ClCCl,O,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20150045351A1,Cc1cc(Br)c2c3c1N(C)C[C@@H]3CN(C(=O)OC(C)(C)C)CC2>>Cc1ccc2c3c1N(C)C[C@@H]3CN(C(=O)OC(C)(C)C)CC2,[Pd],CCO,,CCN(CC)CC,,val
US04438128,CCOC(=O)C(C)C(=O)OCC.CNNC>>Cc1c(O)n(C)n(C)c1=O,,CO,,C[O-].[Na+],,val
US20090131379A1,C[C@H](COC(=O)C(C)(C)C)[C@H]1CC[C@H]2[C@@H](O[Si](C)(C)C(C)(C)C)CCC[C@]12C>>C[C@H](CO)[C@H]1CC[C@H]2[C@@H](O[Si](C)(C)C(C)(C)C)CCC[C@]12C,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US07495007B2,O=C1Cc2ccc(Cl)cc2N1.O=CC1CCCCC1>>O=C1Nc2cc(Cl)ccc2/C1=C/C1CCCCC1,,CO,,C1CCNCC1,,val
US20060120956A1,C[Si](C)(C)c1ccc(N2CCN(C3(c4ccc(Oc5ccc(Br)cc5)cc4)C(=O)NC(=O)NC3=O)CC2)cc1>>C[Si](C)(C)c1ccc(N2CCNCC2)cc1,,CO,,,,val
US20110207754A1,C=C1CC(C=CC#N)C1.C[Si](C)(C)CCOCn1ccc2c(-c3cn[nH]c3)ncnc21>>C=C1CC(C(CC#N)n2cc(-c3ncnc4c3ccn4COCC[Si](C)(C)C)cn2)C1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US06143764,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Nc1c(F)ccc(F)c1F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(F)ccc(F)c4F)cc3)c2cc1OC,,CCN(CC)CC,Cc1ccccc1,O=C([O-])O.[Na+],,val
US20080287479A1,COC(=O)c1cc(C(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(N)cc1F.O=C1CCN(C(=O)OCc2ccccc2)CC1>>COC(=O)c1cc(C(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(NC2CCN(C(=O)OCc3ccccc3)CC2)cc1F,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060025383A1,CCOC1(O[Si](C)(C)C)CC1.Cc1cc(C)c2oc(Nc3ccc(-c4cn([C@@H]5CC[C@H](N6CCNCC6)CC5)c5ncnc(N)c45)cc3F)nc2c1>>Cc1cc(C)c2oc(Nc3ccc(-c4cn([C@@H]5CC[C@H](N6CCN(C7CC7)CC6)CC5)c5ncnc(N)c45)cc3F)nc2c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20010051631A1,Cc1nc2cccc3n(CCCCNC(=O)c4ccccc4)c(=O)c1n23.Cl>>Cc1nc2cccc3n(CCCCNC(=O)c4ccccc4)c(=O)c1n23.Cl,,CO,,,,val
US20100029655A1,CCCOc1ccc(-c2ncc(CCl)cn2)c(C(F)(F)F)c1.Fc1cccc(-c2nc3cn[nH]cc-3n2)c1F>>CCCOc1ccc(-c2ncc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)cn2)c(C(F)(F)F)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05728686,CC(C)CCBr.Cn1c(=O)[nH]c(=O)c2[nH]cnc21>>CC(C)CCn1cnc2c1c(=O)[nH]c(=O)n2C,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US20010046953A1,CCCCCCCCC(=O)NOC.COC(=O)Cl>>CCCCCCCCC(=O)N(OC)C(=O)OC,,C1CCOC1,,CCN(CC)CC,,val
US20040180896A1,Cn1nc(C(C)(C)C)cc1NC(=O)OCC(F)(F)F.NCc1cc(F)ccc1Oc1ccc2c(CN3CCCC3)noc2c1>>Cn1nc(C(C)(C)C)cc1NC(=O)NCc1cc(F)ccc1Oc1ccc2c(CN3CCCC3)noc2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20080312226A1,Br.COc1cccc(C(=O)CSC#N)c1>>COc1cccc(-c2csc(Br)n2)c1,,CC(=O)O,,O,,val
US20130150343A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(CC5CCN(C(=O)OC(C)(C)C)CC5)n4c3)c3ccccc32)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(CC5CCNCC5)n4c3)c3ccccc32)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150080393A1,COC(=O)c1ccc(C)nc1Cl.Cc1cc[nH]n1>>COC(=O)c1ccc(C)nc1-n1ccc(C)n1,,CN(C)C=O,,[H-].[Na+],,val
US20090054422A1,N#Cc1ccc(O)cc1.OCCCBr>>N#Cc1ccccc1OCCCO,,Cc1ccccc1,O,CC#N,O=C([O-])[O-].[K+].[K+],val
US04387238,CC[K].Nc1ccccc1.O=C(O)C1OC1C(=O)O>>CCOC(=O)C1OC1C(=O)Nc1ccccc1,,CCOCC,,O=C(Cl)C(=O)Cl,,val
US20070032478A1,CCn1nc(C)cc1C(=O)Nc1ccc(Cc2ccc3c(c2)C(=CO)C(=O)N3)cc1.CN1CCN(c2ccc(N)cc2)CC1>>CCn1nc(C)cc1C(=O)Nc1ccc(Cc2ccc3c(c2)C(=CNc2ccc(N4CCN(C)CC4)cc2)C(=O)N3)cc1,,CCOC(C)=O,,C1CCOC1,,val
US20110053916A1,CC(C)(C)[Si](C)(C)OC(C(=O)O)c1ccc(-c2ncc(Cl)c(Nc3cc(C4CC4)[nH]n3)n2)s1>>O=C(O)C(O)c1ccc(-c2ncc(Cl)c(Nc3cc(C4CC4)[nH]n3)n2)s1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20090239854A1,C=Cc1ccc(C)nc1.Cc1ccc2[nH]c3c(c2c1)C(=O)N(CO)CC3>>Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(CO)C1=O,,CN1CCCC1=O,,[K+].[OH-],,val
US08816085B2,CCOC(=O)c1c(C)[nH]c2c(O)ccnc12.O=P(Cl)(Cl)Cl>>CCOC(=O)c1c(C)[nH]c2c(Cl)ccnc12,,CC#N,,,,val
US20080045554A1,C1COCCN1.CCCCCn1c2nc(Br)[nH]c2c(=O)n2c(CCC(=O)O)nnc12>>CCCCCn1c2nc(Br)[nH]c2c(=O)n2c(CCC(=O)N3CCOCC3)nnc12,,ClCCl,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20030166644A1,CN(C(=O)Cl)c1ccccc1.OCc1ccc(O)cc1>>CN(C(=O)Oc1ccc(CO)cc1)c1ccccc1,,ClCCl,,,,val
US20150299156A1,C=CC(C)=O.FC(F)(F)c1ccc(S)cc1>>CC(=O)CCSc1ccc(C(F)(F)F)cc1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20110144105A1,COC(=O)c1cnc2[nH]c(C(=CC3CCCC3)c3ccc(C(C)(C)OC4CCCCO4)c(F)c3)cc2c1>>COC(=O)c1cnc2[nH]c(C(CC3CCCC3)c3ccc(C(C)(C)OC4CCCCO4)c(F)c3)cc2c1,[Pd],CO,,,,val
US05252251,COC(=O)C(C)OC1CCCCO1>>CC(CO)OC1CCCCO1,,CCOCC,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20150141401A1,CC(C)(C)OC(=O)NCCBr.O=C1c2ccccc2C(=O)N1O>>CC(C)(C)OC(=O)NCCON1C(=O)c2ccccc2C1=O,,CCN(CC)CC,,CC#N,,val
US20110269738A1,CC(C)Oc1ccc(-c2ncc(Br)s2)cc1C(F)(F)F.CCc1c(C=O)cccc1B1OC(C)(C)C(C)(C)O1>>CCc1c(C=O)cccc1-c1cnc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20110306607A1,O=C(OCc1ccccc1)N1CCC2(CC1)Oc1ccccc1-c1[nH]ncc12>>c1ccc2c(c1)OC1(CCNCC1)c1cn[nH]c1-2,[Pd],CO,,,,val
US06136823,CN.Nc1cc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)c([N+](=O)[O-])c32)c(F)cc1F.c1ccncc1>>CN.CNc1c(F)cc2c(=O)c(C(=O)O)cn(-c3cc(N)c(F)cc3F)c2c1[N+](=O)[O-],,c1ccncc1,,,,val
US20080306082A1,CC(C)(C)OC(=O)N1CCC(C)(C(=O)CC#N)CC1>>CC(C)(C)OC(=O)N1CCC(C)(C(O)CC#N)CC1,,CO,,[BH4-].[Na+],,val
US20130317026A1,Cc1cc(C)c(CNC(=O)c2cc(Br)cc3c2cnn3C2CCCC2)c(=O)[nH]1.O=Cc1ccc(B(O)O)o1>>Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(C=O)o3)cc3c2cnn3C2CCCC2)c(=O)[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090137557A1,COC(=O)CC(C)=O.N=C(N)c1cccc(F)c1OCc1ccccc1>>Cc1cc(=O)nc(-c2cccc(F)c2OCc2ccccc2)[nH]1,,C1COCCO1,CO,C[O-].[Na+],,val
US06420424B1,CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1.CI>>CCOC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)c1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060173041A1,CS(=O)(=O)Cl.FC(F)(F)c1ccc(OC2CCNCC2)c(Cl)c1>>CS(=O)(=O)N1CCC(Oc2ccc(C(F)(F)F)cc2Cl)CC1,,CCN(CC)CC,ClCCl,O=C(O)C(F)(F)F,,val
US05464859,COc1ccc(OC)c2c1CCC(=O)C2.NCc1ccccc1>>COc1ccc(OC)c2c1C=C(NCc1ccccc1)CC2,,Cc1ccccc1,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090131444A1,COC(=O)[C@@H]1C[C@@H](N)CN1C(=O)OC(C)(C)C.O=Cc1cc2c(cn1)OCCO2>>COC(=O)[C@@H]1C[C@@H](NCc2cc3c(cn2)OCCO3)CN1C(=O)OC(C)(C)C,,CO,,[BH3-]C#N.[Na+],,val
US20130178478A1,CCOC(=O)c1nnc(Cl)cc1Nc1ccc2ccn(C)c2n1.N>>Cn1ccc2ccc(Nc3cc(Cl)nnc3C(N)=O)nc21,,CO,,,,val
US20110218197A1,CCOC(=O)c1cc(C(C)(C)C)nn1C>>Cn1nc(C(C)(C)C)cc1C(=O)O,,CO,,O,[Na+].[OH-],val
US20110112063A1,Cc1cc(Nc2nc(Nc3cc(C)c(C4CCNCC4)cc3F)ncc2Cl)n[nH]1.O=C1CCC(=O)C1>>Cc1cc(Nc2nc(Nc3cc(C)c(C4CCN(C5=CC(=O)CC5)CC4)cc3F)ncc2Cl)n[nH]1,,CO,,CCN(C(C)C)C(C)C,[BH3-]C#N.[Na+],val
US20080146625A1,COC(=O)/C(=N/OC1CCCCC1)c1ccc(S(C)(=O)=O)c(Cl)c1>>CS(=O)(=O)c1ccc(/C(=N\OC2CCCCC2)C(=O)O)cc1Cl,,CO,,[Li+].[OH-],,val
US20090137607A1,C=Cc1cnn2cc(-c3ccccc3)c(-c3ccc(C=O)cc3)nc12>>CCc1cnn2cc(-c3ccccc3)c(-c3ccc(C=O)cc3)nc12,[Pd],C1CCOC1,CCO,,,val
US20060135578A1,CCOC(=O)c1cn(C)nc1O.COc1cc(CCl)ccc1OCc1nc(-c2ccccc2)oc1C>>CCOC(=O)c1cn(C)nc1OCc1ccc(OCc2nc(-c3ccccc3)oc2C)c(OC)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090124625A1,COc1cccc(Br)c1N>>Nc1c(O)cccc1Br,,ClCCl,,BrB(Br)Br,,val
US20090181928A1,CCOC(=O)c1ccccc1C=C[C@@H]1COC(C)(C)N1C(=O)OC(C)(C)C>>CCOC(=O)c1ccccc1C=C[C@@H](N)CO,,CO,,Cl,,val
US20100009986A1,CCCCC1(N(C)C)CCC(c2[nH]c3ccc(F)cc3c2C)CC1.C[Si](C)(C)Cl>>CCCCC1(N(C)C)CCC(c2[nH]c3ccc(F)cc3c2C)CC1.Cl,,CCC(C)=O,,,,val
US20040180912A1,BrCc1ccccc1.C#CCOc1ccc(N)c(C(=O)c2ccc(C(C)C)cc2)c1>>C#CCOc1ccc(NCc2ccccc2)c(C(=O)c2ccc(C(C)C)cc2)c1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20120149681A1,C=CB(OCCCC)OCCCC.O=C(O)c1ccnc(Cl)c1F>>C=Cc1nccc(C(=O)O)c1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(=O)N(C)C,O,O=C([O-])[O-].[K+].[K+],,val
US04550105,CC(C)(ON1C(=O)c2ccccc2C1=O)C(=O)OCc1ccc([N+](=O)[O-])cc1>>CC(C)(ON)C(=O)OCc1ccc([N+](=O)[O-])cc1,,ClCCl,,NN,O,val
US20100197681A1,COc1cc(-c2ccc3nc(N)nn3c2)ccc1OCc1ccccc1.O=C(Cl)c1ccc(CN2CCCCC2)cc1>>COc1cc(-c2ccc3nc(NC(=O)c4ccc(CN5CCCCC5)cc4)nn3c2)ccc1OCc1ccccc1,,ClCCl,,c1ccncc1,,val
US20130225524A1,COC(=O)c1cccc(CNC(=O)c2cnc3cc(Br)ccc3c2Nc2cc(C(=O)OC)cc(C(=O)OC)c2)c1.Cc1n[nH]c(C)c1B1OC(C)(C)C(C)(C)O1>>Cc1n[nH]c(C)c1-c1ccc2c(Nc3cc(C(=O)O)cc(C(=O)O)c3)c(C(=O)NCc3cccc(C(=O)O)c3)cnc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US06313097B1,Nc1ccccc1-c1ccccc1[N+](=O)[O-].O=C1CCN(Cc2ccccc2)CC1>>O=[N+]([O-])c1ccccc1-c1ccccc1NC1CCN(Cc2ccccc2)CC1,,ClCCl,,[Na+].[OH-],,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4nccn4CCCC(=O)N(C)C)cc2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4nccn4CCCC(=O)N(C)C)cc2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20060142373A1,CCOC(OCC)OCC.COC(=O)c1ccc2c(c1)N(C(C)=O)C(=O)C2>>CCOC=C1C(=O)N(C(C)=O)c2cc(C(=O)OC)ccc21,,CC(=O)OC(C)=O,,,,val
US20120190860A1,COc1c(Cl)ccc(-c2nc(C(=O)OCc3ccccc3)c(Cl)c(N)c2F)c1F>>COC(=O)c1nc(-c2ccc(Cl)c(OC)c2F)c(F)c(N)c1Cl,,O,,CO,C[O-].[Na+],val
US20130023526A1,CC(=O)Cl.COc1cc(CNC(=O)c2cc(C3=NO[C@H]([C@H]4CO[C@H](CN)CO4)C3)nc(C)n2)ccc1F>>COc1cc(CNC(=O)c2cc(C3=NO[C@H]([C@H]4CO[C@H](CNC(C)=O)CO4)C3)nc(C)n2)ccc1F,,ClCCl,,,,val
US05382379,Br.OCCC1CCC(c2cc(F)c(F)c(F)c2)CC1>>Fc1cc(C2CCC(CCBr)CC2)cc(F)c1F,,O,,,,val
US20020006948A1,CI.O=[N+]([O-])c1ccc(Nc2ccc(O)cc2)c([N+](=O)[O-])c1>>COc1ccc(Nc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040229900A1,O=C=Nc1ccccc1.c1ccc(CN2CC3CNCC(C3)C2)cc1>>O=C(Nc1ccccc1)N1CC2CC(CN(Cc3ccccc3)C2)C1,,ClCCl,,,,val
US20140336381A1,Cc1ccccc1-c1cc(N2CCN(C(=O)OC(C)(C)C)CC2)nnc1C(F)(F)F>>Cc1ccccc1-c1cc(N2CCNCC2)nnc1C(F)(F)F,,CO,,,,val
US20090099190A1,CCN1C(=O)N(c2cc([N+](=O)[O-])c(F)cc2Cl)Cc2cnc(N(C)OC)cc21>>CCN1C(=O)N(c2cc(N)c(F)cc2Cl)Cc2cnc(NC)cc21,[Pd],,,[H][H],,val
US04371529,C=C1C[C@]2(CC)C(=O)C[C@H](O)[C@H]2[C@@H]2CCC3=CC(=O)CC[C@@H]3[C@@H]12.CC(=O)OC(C)=O>>C=C1C[C@]2(CC)C(=O)C[C@H](OC(C)=O)[C@H]2[C@@H]2CCC3=CC(=O)CC[C@@H]3[C@@H]12,,c1ccncc1,,,,val
US20030232863A1,Brc1ccc(Br)cc1.CC(C)C[C@@H](CO[Si](C)(C)C(C)(C)C)/N=C/C(F)F>>CC(C)C[C@@H](CO[Si](C)(C)C(C)(C)C)N[C@@H](c1ccc(Br)cc1)C(F)F,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US05527780,Nc1ncnc2nc[nH]c12.O=C1c2ccccc2C(=O)N1CCCCBr>>Nc1ncnc2c1ncn2C=CCCN1C(=O)c2ccccc2C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20110263562A1,CCOC(C)=O.C[C@@H](CO[C@@H]1CC[C@@H](n2cc3ccc(OCCC4CC4)cc3n2)CC1)NC(=O)OC(C)(C)C>>CC(=O)N[C@@H](C)CO[C@@H]1CC[C@@H](n2cc3ccc(OCCC4CC4)cc3n2)CC1,,CCOC(C)=O,,Cl,,val
US05500423,CC(=O)N1CCC(C(=O)Nc2cccc3cccnc23)CC1>>CC(=O)N1CCC(c2nc3cccc4c3n2CCC4)CC1,O=[Pt],CC(=O)O,,[H][H],,val
US05312828,CCCCc1ncc(/C(C)=C(\Cc2ccccc2)C(=O)OCC)n1Cc1ccccc1Cl>>CCCCc1ncc(/C(C)=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl,,CCO,,[Na+].[OH-],,val
US07157487B2,COC(=O)Cc1ccc([N+](=O)[O-])c(O)c1F>>COC(=O)Cc1ccc(N)c(O)c1F,,CO,O,CC(=O)O,CC(=O)[O-].[Na+],val
US20120252777A1,CNC(=O)c1ccc(N)cc1.COc1ccc(Nc2nc(-c3cccc(C(=O)O)c3)nc3scnc23)cc1OC>>CNC(=O)c1ccc(NC(=O)c2cccc(-c3nc(Nc4ccc(OC)c(OC)c4)c4ncsc4n3)c2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160024031A1,COC(=O)C1(c2ccc(-c3ccc(-c4nn(C)c(C)c4NC(=O)O[C@H](C)c4ccccc4)cc3)cc2)CC1>>Cc1nn(C)c(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)c1NC(=O)O[C@H](C)c1ccccc1,,O,,C1CCOC1,[Li+].[OH-],val
US20110237791A1,COc1ccc(COc2nc(C(Oc3ccc(F)cc3F)c3ccc(S(=O)(=O)C4CC4)cc3)ccc2C2CC2)cc1>>O=c1[nH]c(C(Oc2ccc(F)cc2F)c2ccc(S(=O)(=O)C3CC3)cc2)ccc1C1CC1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20060074071A1,COc1cc(C(=O)N(Cc2cc3ccccc3cn2)C[C@@H]2CCCN2)cc2c1OC(C)(C)O2.O=C1CCC1>>COc1cc(C(=O)N(Cc2cc3ccccc3cn2)C[C@@H]2CCCN2C2CCC2)cc2c1OC(C)(C)O2,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140194431A1,CN1CCn2c(CC3(c4ccccn4)CCCC3)nc(=O)c(OCc3ccccc3)c2C1=O>>CN1CCn2c(CC3(c4ccccn4)CCCC3)nc(=O)c(O)c2C1=O,[Pd],CCO,ClCCl,CO,[H][H],val
US04831041,CC(=O)Nc1ccc(C=O)c(C)c1>>CC(=O)Nc1ccc(CO)c(C)c1,,CO,,[BH4-].[Na+],,val
US05260423,O=[N+]([O-])c1cc([N+](=O)[O-])c(SCc2ccccc2)c(C(F)(F)F)c1>>Nc1cc(N)c(SCc2ccccc2)c(C(F)(F)F)c1,[Ni],C1CCOC1,,,,val
US04110455,O=C(c1ccccc1)c1nc(Cl)ccc1[N+](=O)[O-].S>>O=C(c1ccccc1)c1nc(S)ccc1[N+](=O)[O-],,CCO,,O,[Na],val
US20150099888A1,CC(=O)c1cccnc1Nc1ccc(Cl)cc1.COc1cc(C=O)cc(OC)c1OC>>COc1cc(/C=C/C(=O)c2cccnc2Nc2ccc(Cl)cc2)cc(OC)c1OC,,CO,,Cl,,val
US20100210651A1,CCCCc1noc(C)c1CO.COC(=O)c1cc(=O)[nH]o1>>CCCCc1noc(C)c1COc1cc(C(=O)OC)on1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150344473A1,CC(C)(C)OC(=O)N1CC[C@@H](Oc2ccc(-c3ccnc4[nH]c(-c5ccc(N6CCOCC6)cc5)nc34)cc2C#N)C1>>N#Cc1cc(-c2ccnc3[nH]c(-c4ccc(N5CCOCC5)cc4)nc23)ccc1O[C@@H]1CCNC1,,ClCCl,,Cl,,val
US20080280956A1,Brc1ccccn1.CC(C)=O>>CC(C)(O)c1cccnc1Br,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20130059834A1,CC(=O)N(C)CCCn1nc(-c2cnc3c(n2)c(C(=O)NC(C)(C)C)cn3COCC[Si](C)(C)C)c2cc(OC(F)F)ccc21>>CC(=O)N(C)CCCn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c2cc(OC(F)F)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100305096A1,O=[N+]([O-])c1c(F)cccc1N=P(c1ccccc1)(c1ccccc1)c1ccccc1>>Nc1cccc(F)c1[N+](=O)[O-],,O,,O=C(O)C(F)(F)F,,val
US20100331326A1,C[Si](C)(C)CCOCn1ccc2cc(Br)cnc21.O=C1NCCN1c1ccc2ncsc2c1>>C[Si](C)(C)CCOCn1ccc2cc(N3CCN(c4ccc5ncsc5c4)C3=O)cnc21,I[Cu]I,C1COCCO1,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20120225854A1,O=C(c1ccc(F)cc1)C(F)(F)F.O=S(=O)(c1cccs1)N1CCNCC1>>O=C(c1ccc(N2CCN(S(=O)(=O)c3cccs3)CC2)cc1)C(F)(F)F,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US04554007,CC(C)(C)C(=O)C(=Cc1ccc(Cl)cc1)n1cncn1>>CC(C)(C)C(O)C(=Cc1ccc(Cl)cc1)n1cncn1,,CO,,[BH4-].[Na+],,val
US20040209905A1,COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.COc1ccc(N=C=O)cc1>>COc1ccc(NC(=O)Nc2cc(C)c(Oc3ccnc4cc(OC)c(OC)cc34)cc2C)cc1,,ClC(Cl)Cl,,,,val
US20150080393A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(N3CCC4(CC3)CN[C@H](C(=O)O)C4)nc(N)n2)C(F)(F)F)n1>>Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(N3CCC4(CC3)C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C4)nc(N)n2)C(F)(F)F)n1,,C1CCOC1,ClCCl,Cl,,val
US20130324576A1,CC(C)(C)OC(=O)N1CCC(C(c2ccc(Cl)cc2)C(F)F)CC1.Cl>>Cl.FC(F)C(c1ccc(Cl)cc1)C1CCNCC1,,CO,,,,val
US20070149510A1,BrCc1ccccc1.CC(C)(C)OC(=O)N1CCN(c2cccc3c2COC(=O)N3)CC1>>CC(C)(C)OC(=O)N1CCN(c2cccc3c2COC(=O)N3Cc2ccccc2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20020099212A1,COC(=O)c1ccc2cc(C)cn2c1.O=C(Cl)c1ccc(Cl)cc1Cl>>COC(=O)c1ccc2cc(C)c(Cc3ccc(Cl)cc3Cl)n2c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080045556A1,Br.N#CSCC(=O)c1ccc([N+](=O)[O-])cc1>>O=[N+]([O-])c1ccc(-c2csc(Br)n2)cc1,,CC(=O)O,,O,[Na+].[OH-],val
US20090311217A1,COc1cc(OC)c2c(c1)O/C(=C\c1c(-c3ccccc3)n(C)c3ccccc13)C2=O>>COc1cc(O)c2c(c1)O/C(=C\c1c(-c3ccccc3)n(C)c3ccccc13)C2=O,,ClCCl,,BrB(Br)Br,,val
US04725283,NCCN.O=[N+]([O-])c1cc(Cl)c(Cl)cc1Cl>>NCCNc1cc(Cl)c(Cl)cc1[N+](=O)[O-],,O,,CCO,,val
US20080015191A1,COc1cc(N)cc(OC)c1OC.O=C1CCc2ccc(Oc3cncc(Cl)n3)cc21>>COc1cc(Nc2cncc(Oc3ccc4c(c3)C(=O)CC4)n2)cc(OC)c1OC,,CCOC(C)=O,,,,val
US20120165318A1,CI.COC(=O)c1ccc2nc(-c3ccccc3)c(NC3CC3)nc2c1>>CN(c1nc2cc(C(=O)O)ccc2nc1-c1ccccc1)C1CC1,,C1CCOC1,,[H-].[Na+],,val
US06235900B1,COC(=O)c1ccc(-n2ccc(C)n2)cc1Cl>>Cc1ccn(-c2ccc(C(=O)O)c(Cl)c2)n1,,C1CCOC1,,[Li+].[OH-],,val
US04039551,CCCN(O)CCC.O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1Cl)=NCc1nnc(CCl)n1-2>>CCCN(CCC)Cc1nnc2n1-c1ccc([N+](=O)[O-])cc1C(c1ccccc1Cl)=NC2,,CN(C)C=O,,[H-].[Na+],,val
US20080312316A1,CC(C)c1oc2c(Br)c(N)ccc2c(=O)c1-c1ccc(Cl)cc1.O=C(Cl)Cl.OCc1ccccc1>>CC(C)c1oc2c(Br)c(NC(=O)OCc3ccccc3)ccc2c(=O)c1-c1ccc(Cl)cc1,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US20070010573A1,C[C@H](N)C(=O)OC(C)(C)C.O=S1(=O)CCCO1>>C[C@H](NCCCS(=O)(=O)O)C(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20150291636A1,CCOP(=O)([O-])C(F)(F)C[C@@H](O)[C@@H](O)[C@@H](O)CNOCc1ccccc1.O=COCC(F)(F)F.[Na+]>>CCOP(=O)([O-])C(F)(F)C[C@@H](O)[C@@H](O)[C@@H](O)CN(C=O)OCc1ccccc1.[Na+],,C1CCOC1,,,,val
US06274385B1,C#C.C=Cc1ccc(C=C)cc1.C=Cc1ccccc1.Ic1ccccc1>>C#CCCC#CCCCC,,CN(C)C=O,,,,val
US20070082912A1,CC(=O)CCC(=O)c1cc(Br)ccc1OCc1ccc(F)cc1.Nc1cc(C(=O)O)c2ccccc2c1>>Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1cc(C(=O)O)c2ccccc2c1,,CCOC(C)=O,CN1CCCC1=O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090082311A1,CC(=O)NC(CCc1ccc(-c2ccc(Br)cc2F)cc1Cl)(COC(C)=O)COC(C)=O.Cl>>Cl.NC(CO)(CO)CCc1ccc(-c2ccc(Br)cc2F)cc1Cl,,CO,,,,val
US20050222198A1,ClCc1cc(-c2ccc(Cl)cc2)no1.Fc1ccccc1-c1nc2ccncc2[nH]1>>Fc1ccccc1-c1nc2ccn(Cc3cc(-c4ccc(Cl)cc4)no3)cc-2n1,,CN(C)C=O,,[Na+].[OH-],,val
US20150175628A1,COC(=O)c1ccc([N+](=O)[O-])c(C)c1.NN>>Cc1cc(C(=O)NN)ccc1[N+](=O)[O-],,CCO,O,,,val
US20160002177A1,COc1cc(Br)cc2c(=O)n(COCC[Si](C)(C)C)cnc12.OB(O)c1ccc(F)cc1>>COc1cc(-c2ccc(F)cc2)cc2c(=O)n(COCC[Si](C)(C)C)cnc12,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20060128710A1,Clc1ncccn1.c1nc2c(c(Nc3ccc(N4CCCCCC4)cc3)n1)CCNC2>>c1cnc(N2CCc3c(ncnc3Nc3ccc(N4CCCCCC4)cc3)C2)nc1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20130225552A1,NC1CN(c2ccc3ccccc3n2)C1.O=[N+]([O-])c1cccnc1Cl>>O=[N+]([O-])c1cccnc1NC1CN(c2ccc3ccccc3n2)C1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US05391650,Brc1cccc2c1CC2.Oc1cccc(O)c1>>Oc1cccc(Oc2cccc3c2CC3)c1,,Cc1ccccc1,,CC(=O)N(C)C,O=C([O-])[O-].[K+].[K+],val
US04965155,CCN(CC)c1ccc(C=O)cc1.O=C(O)CN1C(=O)CSC1=S>>CCN(CC)c1ccc(C=C2SC(=S)N(CC(=O)O)C2=O)cc1,,CN(C)C=O,,O,,val
US20140046069A1,CCC(=O)OC(=O)CC.NCc1ccc(N2CCC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)cc1C(F)(F)F>>CCC(=O)NCc1ccc(N2CCC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)cc1C(F)(F)F,,C1CCOC1,O,,,val
US20060208227A1,CC(C)=O.Nc1ccccc1O>>CC(C)Nc1ccccc1O,[Pd],,,O=S(=O)([O-])[O-].[Mg+2],,val
US05922759,COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1.C[C@H](N=C=O)c1cccc2ccccc12>>COc1ccc(C2(OC(=O)NC(C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US04440941,CC(=O)Sc1c(C)cccc1C(=O)N(CC(=O)O)C1CCCC1>>Cc1cccc(C(=O)N(CC(=O)O)C2CCCC2)c1S,,N,,,,val
US20080312183A1,CC(C)(C)OC(=O)NCC(CCn1ccc(=O)[nH]c1=O)COC(c1ccccc1)(c1ccccc1)c1ccccc1>>NCC(CCn1ccc(=O)[nH]c1=O)COC(c1ccccc1)(c1ccccc1)c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140309225A1,CC(C)C(O)[C@H](C)NC(=O)OC(C)(C)C.O=C(O)c1ccc([N+](=O)[O-])cc1>>CC(C)C(OC(=O)c1ccc([N+](=O)[O-])cc1)[C@H](C)NC(=O)OC(C)(C)C,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06441237B1,Cc1cccc(C)c1C(C#N)CO>>Cc1cccc(C)c1C(CN)CO,[Ni],CO,,N,,val
US20080181866A1,COC(=O)c1ccc([C@@H]2NC(C(=O)O)CS2)cc1.O=C(Cl)OCc1ccccc1>>COC(=O)c1ccc([C@H]2SCC(C(=O)O)N2C(=O)OCc2ccccc2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20030125392A1,C=C1CC(=O)O1.Nc1ccc(Nc2ccccc2)cc1>>CC(=O)CC(=O)Nc1ccc(Nc2ccccc2)cc1,,CC(=O)O,,,,val
US20080242667A1,BrBr.Cn1ccc(-c2ccc([N+](=O)[O-])cc2)n1>>Cn1cc(Br)c(-c2ccc([N+](=O)[O-])cc2)n1,,ClC(Cl)Cl,,CCOC(C)=O,,val
US05559111,CC(=O)Cl.CC(C)(C)OC(=O)NCCC1CCNCC1>>CC(=O)N1CCC(CCNC(=O)OC(C)(C)C)CC1,,ClCCl,,CCN(CC)CC,,val
US20010001799A1,CCOc1cc(CO)cc(CO)c1>>CCOc1cc(C=O)cc(CO)c1,O=[Mn]=O,ClCCl,,,,val
US05252540,COC(=O)c1ccccc1S(N)(=O)=O.Cc1cc(C(=O)Cl)nn1C>>COC(=O)c1ccccc1S(=O)(=O)NC(=O)c1cc(C)n(C)n1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080004271A1,O=C1C=CC(=O)O1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1CC(=P(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)O1,,CC(C)=O,,,,val
US05306692,CC(=O)n1ncc2ccc(Oc3c(F)cc(C(F)(F)F)cc3Cl)cc21>>Fc1cc(C(F)(F)F)cc(Cl)c1Oc1ccc2cn[nH]c2c1,,CO,,Cl,,val
US20120225854A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCS.O=C(CBr)C1CC1>>CC(C)(C)OC(=O)N1CCSCC1C1CC1,,CO,,[BH4-].[Na+],,val
US03974127,C=O.CC1(C)CC(O)CC(C)(C)N1>>CC1(C)CC(O)CC(C)(C)N1CO,,c1ccncc1,,,,val
US20150284384A1,CCOC(=O)c1cc(C)n2cc(C(F)(F)F)nc2c1.O=C1CCC(=O)N1I>>CCOC(=O)c1cc(C)n2c(I)c(C(F)(F)F)nc2c1,,CC(=O)O,,,,val
US20160264518A1,Brc1cccc(CCCOC2CCCCO2)c1.CN(C)C=O>>O=Cc1cccc(CCCOC2CCCCO2)c1,,C1CCOC1,,[Li]CCCC,,val
US04859229,COCCl.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(O)c(Cl)cc2F)c1=O>>COCOc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl,,CN(C)C=O,,[H][H],[H-].[Na+],val
US20080139631A1,BrCc1cscn1.CCCc1cc2c(C(F)(F)F)c(C#N)ccc2[nH]1>>CCCc1cc2c(C(F)(F)F)c(C#N)ccc2n1Cc1cscn1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110263588A1,CCOC(=O)C1CCCN(C(=O)c2ccc(F)cc2)C1>>O=C(O)C1CCCN(C(=O)c2ccc(F)cc2)C1,,CO,O,[K+].[OH-],,val
US20040009995A1,CS(=O)O.OCCCCCCBr>>CS(=O)(=O)CCCCCCO,,CO,ClCCl,CCO,O,val
US20100310512A1,COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc(-c3ccc(-c4cnc(CN5CCC[C@@H](NC(=O)OC(C)(C)C)C5=O)[nH]4)cc3)cc2)[nH]1)C(C)C>>COC(=O)N[C@@H](C(=O)N1CCCC1c1ncc(-c2ccc(-c3ccc(-c4cnc(CN5CCCC(N)C5=O)[nH]4)cc3)cc2)[nH]1)C(C)C,,C1COCCO1,ClCCl,Cl,,val
US20060166992A1,CC(=O)NC(C)c1nnc(-c2ccc(Cl)nc2)[nH]c1=O>>Cc1nc(C)n2nc(-c3ccc(Cl)nc3)[nH]c(=O)c12,,C1COCCO1,,O=P(Cl)(Cl)Cl,,val
US20090253725A1,CC(C)(C)OC(=O)N1CCC2(CC1)N=C(CN)NC2=O.O=C(O)C(F)(F)F>>NCC1=NC2(CCNCC2)C(=O)N1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20050054644A1,CNC.OCc1ccccc1B1OCc2ccccc21>>CN(C)Cc1ccccc1B1OCc2ccccc21,,ClCCl,O,CCN(CC)CC,CS(=O)(=O)Cl,val
US04099002,CCI.O=C1NC(c2ccccc2)c2cc(Cl)ccc2N1CC1CC1>>CCN1C(=O)N(CC2CC2)c2ccc(Cl)cc2C1c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20090131444A1,CO.COC(=O)[C@@H]1CC[C@@H](N)CN1C(=O)OC(C)(C)C.O=Cc1cc2c(cn1)OCCO2>>COC(=O)[C@@H]1CC[C@@H](NCc2ccc3c(c2)OCCO3)CN1C(=O)OC(C)(C)C,,CCOC(C)=O,CO,[BH3-]C#N.[Na+],,val
US05250546,CC(C)CCC(N)C(O)c1ccccc1.Cl.ClCCCN1CCCCC1>>CC(C)CCC(NCCCN1CCCCC1)C(O)c1ccccc1.Cl.Cl,,CCO,,,,val
US20110065698A1,C#Cc1cccc(N)c1.COC(=O)c1cccc2c1nc(Cl)c1ccsc12>>C#Cc1cccc(Nc2nc3c(C(=O)OC)cccc3c3sccc23)c1,,CN1CCCC1=O,,O,,val
US20150274704A1,CC(=O)OC(C)=O.Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CCNCC4)CC3)n2)cn1>>CC(=O)N1CCC2(CCC(Nc3nc(Nc4cnn(C)c4)ncc3Cl)CC2)CC1,,ClCCl,,CCN(CC)CC,,val
US20030078251A1,CCOC(=O)CC(=O)O.Cc1cc(C(=O)O)ccc1[N+](=O)[O-]>>CCOC(=O)CC(=O)c1ccc([N+](=O)[O-])c(C)c1,,C1CCOC1,CCOC(C)=O,O=C(n1ccnc1)n1ccnc1,,val
US20140179715A1,CC(C)(C)OC(=O)N1CCn2c1cc(Cl)nc2=O.OCc1ccc(Oc2cccc(C(F)(F)F)c2)c(Cl)c1>>O=c1nc(OCc2ccc(Oc3cccc(C(F)(F)F)c3)c(Cl)c2)cc2n1CCN2,,C1CCOC1,,[H-].[Na+],,val
US20150344480A1,CC(C)(C)OC(=O)N1CCNCC1.CNN.S=C(n1ccnc1)n1ccnc1>>CN(N)C(=S)N1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,,,val
US20100249085A1,Cc1ccc(Cn2nc(-c3nc(-c4ccc(I)cc4)no3)cc2C)cc1.OCC(F)(F)F>>Cc1ccc(Cn2nc(-c3nc(-c4ccc(OCC(F)(F)F)cc4)no3)cc2C)cc1,[Cu]I,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20130029995A1,CC1CCN(c2nc(C(F)(F)F)ccc2CN)CC1.O=C(Nc1cnc2[nH]ncc2c1)Oc1ccccc1>>CC1CCN(c2nc(C(F)(F)F)ccc2CNC(=O)Nc2cnc3[nH]ncc3c2)CC1,CN(C)c1ccncc1,CC#N,,,,val
US06358980B1,CC#CCOc1ccc(S(=O)(=O)CC2(C(=O)NO)CCN(C(=O)C3(C)COC(C)(C)OC3)CC2)cc1>>CC#CCOc1ccc(S(=O)(=O)CC2(C(=O)NO)CCN(C(=O)C(C)(CO)CO)CC2)cc1,,C1CCOC1,CCOC(C)=O,Cl,,val
US20080194565A1,CC(C)(C)OC(=O)C(CCNC(=O)OCc1ccccc1)C(O)CCc1ccc(-c2ccccc2)cc1.O=C(O)c1ccccc1>>CC(C)(C)OC(=O)C(CCNC(=O)OCc1ccccc1)C(CCc1ccc(-c2ccccc2)cc1)OC(=O)c1ccccc1,CN(C)c1ccncc1,ClCCl,O,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US20080312226A1,O=C(O)c1c[nH]c2ccccc12.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>O=C(Nc1c[nH]c2ccccc12)N1CCN(c2nc(-c3ccccc3)ns2)CC1,,Cc1ccccc1,O,CCN(CC)CC,,val
US20050227995A1,COC(O[Si](C)(C)C)=C(C)C.O=Cc1cc(F)ccc1F>>COC(=O)C(C)(C)C(O)c1cc(F)ccc1F,Cl[Ti](Cl)(Cl)Cl,ClCCl,,O,,val
US06326386B1,CC(C)N(CCc1nnnn1C)C(=O)c1cc(O)cc(Cl)c1.Cc1ccc(S(=O)(=O)OCCN(C(=O)OC(C)(C)C)c2ccncc2)cc1>>CC(C)N(CCc1nnnn1C)C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20100144772A1,CC(C)(C)OC(=O)Nc1nc(CCOc2ccc(F)cc2)cs1>>Nc1nc(CCOc2ccc(F)cc2)cs1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090156646A1,O=C(NCCCO)OCc1ccccc1.O=Cc1cccc(O)c1>>O=Cc1cccc(OCCCNC(=O)OCc2ccccc2)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06956049B1,Brc1csc(C#Cc2ccccc2)n1.CI>>Cc1cnc(C#Cc2ccccc2)s1,,C1CCOC1,CCCCC,[Li]C(C)(C)C,,val
US20080004271A1,CS(=O)c1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(C(N)=O)sc2n1.NCC(O)CO>>NC(=O)c1sc2nc(NCC(O)CO)nc(-c3ccc(Cl)c(Cl)c3)c2c1N,,CCO,,,,val
US20020115861A1,CC(C)Cn1c(CO)nc2c(N)nc3ccccc3c21.O=S(Cl)Cl>>CC(C)Cn1c(CCl)nc2c(N)nc3ccccc3c21.Cl,,CCOCC,,,,val
US20130072492A1,COC(=O)C(C)c1cnccn1.O=C1CCC(=O)N1Br>>COC(=O)C(C)(Br)c1cnccn1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20110136802A1,COc1cc(C)cc2c1[C@]1(C)CC[C@H]3C(C)(C)CCC[C@]3(C)[C@H]1CS2>>Cc1cc(O)c2c(c1)SC[C@H]1[C@@]2(C)CC[C@H]2C(C)(C)CCC[C@@]21C,,ClCCl,,BrB(Br)Br,,val
US20110060013A1,Clc1cc(Cl)nc(Cl)c1.F[C@H]1CCNC1>>F[C@H]1CCN(c2cc(Cl)nc(Cl)c2)C1,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US04968704,CN(CCN(C)c1ccc([N+](=O)[O-])cc1)c1ccncc1>>CN(CCN(C)c1ccc(N)cc1)c1ccncc1,,CO,,,,val
US06051722,CC=O.CS(=O)CC(=O)c1ccccc1O>>Cc1cc(=O)c2ccccc2o1,,CCOC(C)=O,Cc1ccccc1,C1CCNCC1,,val
US20090082379A1,CSc1nccc(CO)n1.O=S(Cl)Cl>>CSc1nccc(CCl)n1,,ClCCl,,CN(C)C=O,,val
US20040192767A1,CCOC(=O)Cc1ccoc1C>>Cc1occc1CCO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05356886,CC(C)OP(=O)(/C=C/C(CO)CO)OC(C)C.COC(C)(OC)OC>>CC(=O)OCC(/C=C/P(=O)(OC(C)C)OC(C)C)CO,,C1CCOC1,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20110077235A1,CC(C)(O)c1ccc(C(=O)Nc2cc(N3CCC[C@@H](C(=O)O)C3)n3nccc3n2)cc1.CN>>CNC(=O)[C@@H]1CCCN(c2cc(NC(=O)c3ccc(C(C)(C)O)cc3)nc3ccnn23)C1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20100267774A1,CC(=O)OCCc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3)ccc2=O)c(F)c1>>Nc1c(C(=O)c2ccc(F)cc2)ccc(=O)n1-c1c(F)cc(CCO)cc1F,,Cl,,,,val
US05563280,CN=C=O.O=c1cc(Oc2c(Cl)cccc2Cl)c2cc(O)ccc2o1>>CNC(=O)c1ccc2oc(=O)cc(Oc3c(Cl)cccc3Cl)c2c1,,CN(C)C=O,,CCN(CC)CC,,val
US05753017,CCBr.CCNc1cccc(C)n1>>CCN(CC)c1cccc(C)n1,,Cc1ccccc1,,[H-].[Na+],,val
US06365602B1,N#Cc1ccc(C(=O)O)c2ccccc12.O=C(Cl)C(=O)Cl>>N#Cc1ccc(C(=O)Cl)c2ccccc12,,CN(C)C=O,,ClCCl,,val
US20120094964A1,COC(=O)c1ccc(S(=O)(=O)NCc2ccc(C(F)(F)F)nc2)cc1.FC(F)(F)c1cnc(Cl)c(Cl)c1>>COC(=O)c1ccc(S(=O)(=O)N(Cc2ccc(C(F)(F)F)nc2)c2ncc(C(F)(F)F)cc2Cl)cc1,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110124635A1,C=C(C)CC(O)(CCN(C(=O)OC)[C@H]1CCCN(C(=O)OC(C)(C)C)C1)c1ccccc1>>C=C(C)C[C@]1(c2ccccc2)CCN([C@H]2CCCN(C(=O)OC(C)(C)C)C2)C(=O)O1,,C1CCOC1,CCOCC,[H-].[Na+],,val
US20160108039A1,CC(C)(C)OC(=O)N1CCC1CN.CCC(Br)C(=O)OC>>CCC(NCC1CCN1C(=O)OC(C)(C)C)C(=O)OC,,ClCCl,,CCN(CC)CC,O,val
US20070244125A1,BrCC1CC1.O=C(c1ccc2[nH]c(C(=O)N3CCOCC3)cc2c1)N1CCN(C2CCCC2)CC1>>O=C(c1ccc2c(c1)cc(C(=O)N1CCOCC1)n2CC1CC1)N1CCN(C2CCCC2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US04127646,CC(=O)c1c(O)oc(=O)c(C(C)=O)c1O.CS(=O)(=O)Nc1cc(NS(C)(=O)=O)cc([N+](=O)[O-])c1>>CC(=O)C1=C(O)C(=C(C)Nc2cc(NS(C)(=O)=O)cc(NS(C)(=O)=O)c2)C(=O)OC1=O,[Pd],CCO,,[H][H],,val
US20030225059A1,C=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>OCC(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,O=[Os](=O)(=O)=O,C1CCOC1,O,O=S([O-])O.[Na+],,val
US20070167460A1,CC(C)(O)C#Cc1ccc(N)nc1>>C#Cc1ccc(N)nc1,,Cc1ccccc1,,[Na+].[OH-],,val
US04473568,C1CSCN1.CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)cc21>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCSC3)cc21,,CN(C)C=O,,CC#N,,val
US04027029,CCOC(=O)c1nc2n(n1)-c1ccc(Cl)cc1C(c1ccccc1F)=NC2.CNC>>CN(C)C(=O)c1nc2n(n1)-c1ccc(Cl)cc1C(c1ccccc1F)=NC2,,CO,,CN,,val
US06197975B1,Cc1cc(C)cc(-c2[nH]c3ccc([N+](=O)[O-])cc3c2CCN(CCCCc2ccc(N)c(S(C)(=O)=O)c2S(C)(=O)=O)C(=O)OC(C)(C)C)c1>>Cc1cc(C)cc(-c2[nH]c3ccc(N)cc3c2CCN(CCCCc2ccc(N)c(S(C)(=O)=O)c2S(C)(=O)=O)C(=O)OC(C)(C)C)c1,[Pd],,,,,val
US20120295884A1,CI.COC(=O)[C@@H]1C[C@H](NC(=O)OCC(Cl)(Cl)Cl)CN1C(=O)OC(C)(C)C>>COC(=O)[C@@H]1C[C@H](N(C)C(=O)OCC(Cl)(Cl)Cl)CN1C(=O)OC(C)(C)C,,CN(C)C=O,,O,[H-].[Na+],val
US20050171130A1,CC#CCO.CC1(COc2cc(Cl)ncn2)CC1(Cl)Cl>>CC#CCOc1cc(OCC2(C)CC2(Cl)Cl)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US08841455B2,CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(C(=O)O)ccn34)c12.CN>>CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(C(=O)NC)ccn34)c12,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US04922021,CS(=O)(=O)Cl.Cc1cccc(C)c1N(CC(C)O)S(C)(=O)=O>>Cc1cccc(C)c1N(CC(C)OS(C)(=O)=O)S(C)(=O)=O,,ClCCCl,,CCN(CC)CC,,val
US05864039,COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1.O=C1NC(=O)c2c(CCCCCCBr)cccc21>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCCN2C(=O)c3ccccc3C2=O)CC1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090054475A1,CC(C)(C)OC(=O)N1CCC(F)(c2nc(COc3ccc(S(C)(=O)=O)cc3)cs2)CC1.Cl>>CS(=O)(=O)c1ccc(OCc2csc(C3(F)CCNCC3)n2)cc1.Cl,,C1COCCO1,CO,,,val
US20120035214A1,CC(=O)NCCc1ccccc1-c1ccc([C@H]2CN(C(=O)OC(C)(C)C)CC[C@@H]2c2cccnc2)c(Cl)c1>>CC(=O)NCCc1ccccc1-c1ccc([C@H]2CNCC[C@@H]2c2cccnc2)c(Cl)c1,,ClCCl,,Cl,,val
US20050215610A1,CC(=O)Cl.CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(C2CCNCC2)cn1>>CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(C2CCN(C(C)=O)CC2)cn1,,ClCCl,,CCN(CC)CC,,val
US20120214803A1,CCNCC.O=S(=O)(Nc1cccc2c(Cl)ccnc12)c1ccccc1>>CCN(CC)c1ccnc2c(NS(=O)(=O)c3ccccc3)cccc12,,CCCCO,,CCN(C(C)C)C(C)C,,val
US05004748,C#CCO.COC(=O)c1cc(C(=O)OC)c(Br)cn1>>COC(=O)c1cc(C(=O)OC)c(C#CCO)cn1,,ClCCl,,,,val
US20120316161A1,CCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1Cl.COc1cc(C)ccc1B(O)O>>COC(=O)Cc1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc(C)cc1OC,,COCCOC,O,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20070249680A1,CC(=O)N1CCC(N=[N+]=[N-])(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCC(C)(C)CC3)c2)CC1.CC(=O)O>>CC(=O)N1CCC(N)(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCC(C)(C)CC3)c2)CC1.CC(=O)O,[Zn],C1CCOC1,,,,val
US20080242672A1,CC(C)(C)OC(=O)N1CCNCC1.Cc1c(C=O)sc2ccccc12>>Cc1c(CN2CCN(C(=O)OC(C)(C)C)CC2)sc2ccccc12,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160122343A1,COc1ccc(Cn2cnc3c(CNCc4ccccc4)nccc3c2=O)c(OC)c1>>O=c1[nH]cnc2c(CNCc3ccccc3)nccc12,,O=C(O)C(F)(F)F,,,,val
US20130109708A1,COc1cc(C)ccc1C(=O)NS(C)(=O)=O.O=C1CCC(=O)N1Br>>COc1cc(CBr)ccc1C(=O)NS(C)(=O)=O,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,,,val
US20120202785A1,COc1ccnc(C)c1C#N.O=P(Cl)(Cl)Cl>>Cc1nccc(Cl)c1C#N,,O=P(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20110190258A1,Cc1cc([C@H](Nc2ccc(C)c(C3OCCO3)c2)C(F)(F)F)ccc1Cl>>Cc1cc([C@H](Nc2ccc(C)c(C=O)c2)C(F)(F)F)ccc1Cl,,C1CCOC1,CCOC(C)=O,Cl,,val
US04033947,CI.O=C1CC(=S)Nc2ccc(Cl)cc2N1c1ccccc1>>CSC1=Nc2ccc(Cl)cc2N(c2ccccc2)C(=O)C1,,CO,,[Na+].[OH-],,val
US20100240867A1,CCCCCCCCCCCCCCCCCCOC1CC(COc2ccc3c(c2)C(=O)c2ccccc2-3)CC(OCCCCCCCCCCCCCCCCCC)C1OCCCCCCCCCCCCCCCCCC.Clc1ccc([Mg]Br)cc1>>CCCCCCCCCCCCCCCCCCOC1CC(COc2ccc3c(c2)C(O)(c2ccc(Cl)cc2)c2ccccc2-3)CC(OCCCCCCCCCCCCCCCCCC)C1OCCCCCCCCCCCCCCCCCC,,C1CCOC1,,,,val
US05716948,COc1ccc(N2C(=O)[C@@H](NC(=O)Cc3ccccc3)[C@H]2C=O)cc1.O=C(C=P(c1ccccc1)(c1ccccc1)c1ccccc1)[C@@H]1CCCO1>>COc1ccc(N2C(=O)[C@@H](NC(=O)Cc3ccccc3)[C@H]2C=CC(=O)[C@@H]2CCCO2)cc1,,CC#N,,,,val
US20160108039A1,COC(=O)C(C)N(Cc1ccccc1)CC1CCN1C(=O)OC(C)(C)C>>COC(=O)[C@H](C)N(Cc1ccccc1)CC1CCN1,,C1COCCO1,,Cl,,val
US20100016379A1,CCOC(=O)Cl.COC(=O)c1ccc(C(=O)O)c(O)c1O.NCc1ccccc1>>COC(=O)c1ccc2c(=O)n(Cc3ccccc3)c(=O)oc2c1O,,ClCCl,,CCN(CC)CC,,val
US06140332,Cc1c(-c2cccc[n+]2Cc2ccccc2)[nH]c2ncnc(Cl)c12.Nc1cccc(Cl)c1>>Cc1c(-c2ccccn2)[nH]c2ncnc(Nc3cccc(Cl)c3)c12,,CC(C)O,,,,val
US04636501,COCCOS(C)(=O)=O.O=C(NCCNCC(O)COc1ccc(O)cc1)N1CCOCC1>>COCCOc1ccc(OCC(O)CNCCNC(=O)N2CCOCC2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060154912A1,COC(=O)c1ccc(OCCCc2ccc(OCCCC3CCCCC3)cc2)c(C(=O)N2CCC(C(=O)OC)CC2)c1>>O=C(O)c1ccc(OCCCc2ccc(OCCCC3CCCCC3)cc2)c(C(=O)N2CCC(C(=O)O)CC2)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US05679710,C=C(C)C(=O)OCCO.O=C(O)c1cc(I)cc(I)c1I>>C=C(C)C(=O)OCCOC(=O)c1cc(I)cc(I)c1I,,CCOCC,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20120178748A1,Cc1c(CO)nc2c3c(ccn12)CCCC3.O=S(Cl)Cl>>Cc1c(CCl)nc2c3c(ccn12)CCCC3,,ClCCl,,,,val
US20050148602A1,COC(=O)[C@@H]1CCCN1.O=C=Nc1cc(Cl)cc(Cl)c1>>COC(=O)[C@@H]1CCCN1C(=O)Nc1cc(Cl)cc(Cl)c1,,ClCCl,,CCN(CC)CC,Cl,val
US05330973,CN(C)C=O.Cc1ccc(S(=O)(=O)O)cc1.OCc1ccccc1>>c1ccc(COCc2ccccc2)cc1,,C1CCOC1,CN(C)C=O,,,val
US20100087427A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2O)C(C)C)ccc1OC.FC(F)(F)Oc1cccc(CBr)c1>>COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2OCc2cccc(OC(F)(F)F)c2)C(C)C)ccc1OC,,O,,CC#N,CC#N,val
US04721726,CC(C)(C)C(=O)OCCl.CC(C)(C)OC(=O)NCCC(=O)O>>CC(C)(C)OC(=O)NCCC(=O)OCOC(=O)C(C)(C)C,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20060178377A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1nc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)n2n1>>COC(=O)c1nc2nc(C)c(CC(=O)OC(C)(C)C)c(-c3ccc(Cl)cc3Cl)n2n1,,C1CCOC1,,CCN(CC)CC,,val
US20080108102A1,CC#N.CCI.CN(C)c1ccc(-c2ccncc2)cc1>>CCC[n+]1ccc(-c2ccc(N(C)C)cc2)cc1.[I-],,CC#N,,CCOCC,,val
US20060148806A1,CCC(=O)CC.Nc1cc(F)c(F)c(F)c1>>CCC(CC)Nc1cc(F)c(F)c(F)c1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140045862A1,COS(=O)(=O)OC.COc1ccc(CN(c2ccncn2)S(=O)(=O)c2cc(F)c(O[C@H]3C[C@@H](O)C[C@@H]3c3ccnn3C)cc2F)c(OC)c1>>COc1ccc(CN(c2ccncn2)S(=O)(=O)c2cc(F)c(O[C@H]3C[C@@H](OC)C[C@@H]3c3ccnn3C)cc2F)c(OC)c1,,C1CCOC1,,[H-].[Na+],,val
US20150274704A1,Cc1cnc(Cl)nc1NC1CCC2(CC1)CCN(C(=O)OC(C)(C)C)CC2.Cn1cc(N)cn1>>Cc1cnc(Nc2cnn(C)c2)nc1NC1CCC2(CC1)CCN(C(=O)OC(C)(C)C)CC2,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20090247573A1,CCCCC1(N(C)C)CCC(c2c(C)c3ccccc3n2C)(c2c(C)c3ccccc3n2C)CC1.C[Si](C)(C)Cl>>CCCCC1(N(C)C)CCC(c2c(C)c3ccccc3n2C)(c2c(C)c3ccccc3n2C)CC1.Cl,,C1CCCCC1,,,,val
US20160271130A1,CC(C)(C)c1cc(Cl)nc(Cl)n1.Cc1ccc(N)cc1>>Cc1ccc(Nc2cc(C(C)(C)C)nc(Cl)n2)cc1,,CC#N,,CCN(CC)CC,,val
US20080306115A1,Cc1c(C(=O)OCC(Cl)(Cl)Cl)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(OCc2ccccc2)cc1>>Cc1c(C(=O)OCC(Cl)(Cl)Cl)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(O)cc1,,Br,CC(=O)O,CCO,,val
US20160158207A1,CC(=O)N1CCc2c(c(N3CCN(C(=O)OC(C)(C)C)c4cc(-c5cnn(C)c5)ccc43)nn2[C@H]2CCOC2)C1>>CC(=O)N1CCc2c(c(N3CCNc4cc(-c5cnn(C)c5)ccc43)nn2[C@H]2CCOC2)C1,,CO,,Cl,,val
US20130310419A1,CC1(C)CCOc2ccc(C(=O)CBr)cc21.CCC(=O)CC(C)=O>>CCC(=O)C(CC(=O)c1ccc2c(c1)C(C)(C)CCO2)C(C)=O,,Cc1ccccc1,,O,[Na],val
US20060004017A1,CC(C)NC(C)C.COc1cc2c(Oc3ccc4[nH]ccc4c3)ncnc2cc1OC[C@H]1CO1>>COc1cc2c(Oc3ccc4[nH]ccc4c3)ncnc2cc1OC[C@H](O)CN(C(C)C)C(C)C,,CN(C)C=O,,,,val
US05616793,CC(C)CC1CC(=O)OC(=O)C1.N>>CC(C)CC(CC(N)=O)CC(=O)O,,COC(C)(C)C,,O,,val
US20150018328A1,C[C@@H](Nc1nc(Cl)nc(N[C@H](C)C2CC2)n1)C1CC1.Cc1cn[nH]c1>>Cc1cnn(-c2nc(N[C@H](C)C3CC3)nc(N[C@H](C)C3CC3)n2)c1,,C1CCOC1,,[H-].[Na+],,val
US08188082B2,COCc1nc(I)cn1CCNC(=O)OC(C)(C)C.Cl>>COCc1nc(I)cn1CCN.Cl,,ClCCl,,C1COCCO1,,val
US20160157491A1,O=C1CCCc2cc(Br)ccc21.O=Cc1ccc(OC(F)(F)F)cc1>>O=C1/C(=C/c2ccc(OC(F)(F)F)cc2)CCc2cc(Br)ccc21,,CCO,,[Na+].[OH-],,val
US04855086,COc1cccc(CN)c1.O=C(O)/C=C/CCC#Cc1ccccc1>>COc1cccc(CNC(=O)/C=C/CCC#Cc2ccccc2)c1,,CCOCC,,CCN(CC)CC,,val
US20120196872A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1cccc(C2CNC3(COCCOC3)C(=O)N2)c1>>COc1cccc(C2CN(C(=O)OC(C)(C)C)C3(COCCOC3)C(=O)N2)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20120094999A1,C=CC(=O)Cl.Nc1cccc(Oc2ncnc3c2c(-c2cccnc2)cn3CO)c1>>C=CC(=O)Nc1cccc(Oc2ncnc3c2c(-c2cccnc2)cn3CO)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160145271A1,COC(=O)C(C)(C)c1nnc(-c2nn(COCC[Si](C)(C)C)c3nc(C)ccc23)nc1Cl.N>>Cc1ccc2c(-c3nnc4c(n3)NC(=O)C4(C)C)nn(COCC[Si](C)(C)C)c2n1,,CC#N,,,,val
US20110200546A1,COC(=O)CC/C(C)=C/c1ccccc1>>C/C(=C\c1ccccc1)CCCO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120196872A1,CC(C)(C)OC(=O)N1CC(c2ccc(F)cc2)NC(=O)C12COCCOC2.COC(=O)CBr>>COC(=O)CN1C(=O)C2(COCCOC2)N(C(=O)OC(C)(C)C)CC1c1ccc(F)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20080167348A1,CSCc1cc(Br)ccc1NS(=O)(=O)c1sc2ccc(F)cc2c1C.O=C(OO)c1cccc(Cl)c1>>Cc1c(S(=O)(=O)Nc2ccc(Br)cc2CS(C)=O)sc2ccc(F)cc12,,ClC(Cl)Cl,,,,val
US20130102611A1,CCOC(=O)CCC(=O)NCCN1CCCc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc21>>Cc1ccc(-c2nc3c(nc2-c2ccc(C)cc2)N(CCNC(=O)CCC(=O)O)CCC3)cc1,,CCO,,[Na+].[OH-],,val
US20050203081A1,CC(C)(C)O.COC(=O)COc1c(C(=O)OC)sc2cc(C(=O)O)ccc12.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COC(=O)COc1c(C(=O)OC)sc2cc(NC(=O)OC(C)(C)C)ccc12,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,,val
US20040092598A1,COC(=O)CCCCNC(=O)c1ccc(N(C)C)c2ccccc12.NO>>CN(C)c1ccc(C(=O)NCCCCC(=O)NO)c2ccccc12,,CO,,Cl,C[O-].[Na+],val
US04496579,O=C(O)C1=COc2ccccc2O1.O=C=O>>O=C(O)C1=C(C(=O)O)Oc2ccccc2O1,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US20140005169A1,C[C@H]1C[C@]1(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.Cc1sc(N)c(C(=O)c2ccc(Cl)cc2)c1C>>Cc1sc(NC(=O)[C@@]2(NC(=O)OCC3c4ccccc4-c4ccccc43)C[C@@H]2C)c(C(=O)c2ccc(Cl)cc2)c1C,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US05786486,CCOC(=O)C=Cc1ccc(C=CC(=O)[O-])c2ccccc12>>O=C(O)C=Cc1ccc(C=CC(=O)O)c2ccccc12,,CCO,,Cl,[K+].[OH-],val
US20070088029A1,O=C(Cl)CCCCBr.OCc1ccccc1>>O=C(CCCCBr)OCc1ccccc1,,CCOC(C)=O,O,CCN(CC)CC,ClCCl,val
US20040180911A1,CC(=O)OC(C)=O.NC[C@@H]1C[C@@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1>>CC(=O)NC[C@@H]1C[C@@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1,,CN(C)C=O,,,,val
US20040002475A1,N#CCCBr.Nc1ncnc2nc[nH]c12>>N#CCCn1cnc2c(N)ncnc21,,CN(C)C=O,,[H-].[Na+],,val
US04363813,CC(=O)C(Cl)C(C)=O.COc1cc(C(N)=S)cc(OC)c1OC>>COc1cc(-c2nc(C)c(C(C)=O)s2)cc(OC)c1OC,,c1ccccc1,,,,val
US20130116243A1,CC(C)(C)OC(=O)NC1(c2ccc(-c3[nH]c(=O)c(N)cc3-c3ccccc3)cc2)CCC1.CC(Cl)C(=O)Cl>>CC1Oc2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc2NC1=O,,C1CCOC1,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US06395766B1,CC1(C)CC(=O)c2c(Br)c[nH]c2C1.N#Cc1ccccc1F>>CC1(C)CC(=O)c2c(Br)cn(-c3ccccc3C#N)c2C1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20050065066A1,N#CCS(=O)(=O)c1ccccc1.O=Cc1ccc(OCC(=O)O)cc1.[N-]=[N+]=[N-]>>N#Cc1[nH]nnc1-c1ccc(OCC(=O)O)cc1,,CCO,CN(C)C=O,O,,val
US20160176882A1,CSc1ncc(Br)c(Cl)n1.NN>>CSc1ncc(Br)c(NN)n1,,CCO,,,,val
US05972976,CCOP(=O)(Cc1ccccc1)OCC.Nc1ncccc1C=O>>Nc1ncccc1/C=C/c1ccccc1,,C1CCOC1,,[K+].[OH-],,val
US20040248923A1,COCc1cccc([N+](=O)[O-])c1C>>COCc1cccc(N)c1C,[Pd],CCO,CCOC(C)=O,,,val
US20040171881A1,CCc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1.CN(c1nc(C(=O)O)co1)S(C)(=O)=O>>CCc1cccc(CNC[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2coc(N(C)S(C)(=O)=O)n2)c1,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US04612309,COc1cccc2c1OC(C)(C)C2N1CCCCC1>>CC1(C)Oc2c(O)cccc2C1N1CCCCC1,,CC(=O)O,,Br,,val
US20140288062A1,CCOC(=O)c1ccc2c(c1[N+](=O)[O-])OCCO2>>O=C(O)c1ccc2c(c1[N+](=O)[O-])OCCO2,,CC#N,O,[Li+].[OH-],,val
US05155130,C=CC=O.O=Cc1cc(Oc2ccccc2)ccc1O>>O=CC1=Cc2cc(Oc3ccccc3)ccc2OC1,,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20040248887A1,C[C@@H](C(=O)O)N(C#N)C(=O)OC(C)(C)C.[BH4-].[Na+]>>CC(C)(C)OC(=O)N[C@H](CO)CC#N.[BH4-].[Na+],,C1CCOC1,O,CC(C)COC(=O)Cl,CCN(CC)CC,val
US04853381,NCc1ccccc1.O=[N+]([O-])c1ccc(CCCCOCCCCCCBr)cc1>>O=[N+]([O-])c1ccc(CCCCOCCCCCCNCc2ccccc2)cc1,,Cl,,,,val
US20160235734A1,Cc1ccc(S(=O)(=O)OCC2CCN(C(=O)OC(C)(C)C)CC2)cc1.O=C(O)[C@](O)(c1ccccc1)c1cccc(O)c1>>CC(C)(C)OC(=O)N1CCC(COC(=O)[C@](O)(c2ccccc2)c2cccc(O)c2)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])O.[K+],,val
US04543402,O=C(O)CC(=O)O.O=Cc1ccc(O)cc1>>O=C(O)C=Cc1ccc(O)cc1,,CCOCC,,,,val
US20150094328A1,C[Si](C)(C)N=[N+]=[N-].FC1(F)CCC2OC2C1>>[N-]=[N+]=N[C@@H]1CCC(F)(F)C[C@H]1O,,CCOCC,CO,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US20030212071A1,CCCS(=O)(=O)Cl.N#CCN>>CCCS(=O)(=O)NCC#N,,ClCCCl,,CCN(CC)CC,,val
US20100197761A1,COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)cc(O[Si](C)(C)C(C)(C)C)c(Cl)c4C)c3)ccc21>>COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)cc(O)c(Cl)c4C)c3)ccc21,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20030195160A1,COc1ccc(CCCCN=[N+]=[N-])cc1>>COc1ccc(CCCCN)cc1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05942511,C=CCS.CCCCOc1ccc(Cl)nn1>>C=CCSc1ccc(OCCCC)nn1,,CO,,[Na],,val
US06159904,CCn1nccc1O.Cc1c(C(=O)O)ccc2c1C(Cl)C(Cl)CS2(=O)=O>>CCn1nccc1OC(=O)c1ccc2c(c1C)C(Cl)C(Cl)CS2(=O)=O,,CCC(C)(C)O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20040147535A1,CN(C)CCN.O=C(Nc1cccc(C(F)(F)F)c1)c1ccccc1NCc1ccnc(Br)c1>>CN(C)CCNc1cc(CNc2ccccc2C(=O)Nc2cccc(C(F)(F)F)c2)ccn1,,c1ccncc1,,,,val
US04702561,CC(=O)Nc1ccc(N)cc1.O=C1c2ccccc2C(=O)c2c(NC3CCCCC3)ccc(Br)c21>>CC(=O)Nc1ccc(Nc2ccc(NC3CCCCC3)c3c2C(=O)c2ccccc2C3=O)cc1,,c1ccncc1,,,,val
US04784791,CCCCCCCCOc1ccc(-c2ccc(CO)cc2)cc1.O=S(Cl)Cl>>CCCCCCCCOc1ccc(-c2ccc(CCl)cc2)cc1,,Cc1ccccc1,,,,val
US04073932,CC1(C)OC(=O)CC(=O)O1.O=C=Nc1ccc(Cl)c(Cl)c1>>CC1(C)OC(=O)C(C(=O)Nc2ccc(Cl)c(Cl)c2)=C(O)O1,,CS(C)=O,O,CCN(CC)CC,Cl,val
US05283241,CC(C)(CC(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3N)cc2)C1=O)NC(=O)OC(C)(C)C.C[Si](C)(C)N=C=O>>CC(C)(CC(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3NC(N)=O)cc2)C1=O)NC(=O)OC(C)(C)C,,ClCCl,,,,val
US05118686,CCCOc1ccccc1C(=N)N.CCOC(=O)CC#N>>CCCOc1ccccc1-c1nc(N)cc(=O)[nH]1,,CCO,O,,,val
US20050131014A1,COC(=O)Cc1ccc(C=O)cc1.Nc1cccc(-c2c(C(=O)c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1>>COC(=O)Cc1ccc(CNc2cccc(-c3c(C(=O)c4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)cc1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20020151535A1,Cc1ccc(S(=O)(=O)OCc2noc([C@H](CCCC3CCCCC3)CC(=O)OC(C)(C)C)n2)cc1.N>>CC(C)(C)OC(=O)C[C@@H](CCCC1CCCCC1)c1nc(CN)no1,,C1CCOC1,CCOC(C)=O,,,val
US20080090905A1,CS(=O)(=O)Oc1ccc(OCCc2ccc(CC(SCCc3ccc(O)cc3)C(=O)O)cc2)cc1.C[C@H](N)c1ccc2ccccc2c1>>CS(=O)(=O)Oc1ccc(OCCc2ccc(CC(SCCc3ccc(O)cc3)C(=O)O)cc2)cc1.C[C@H](N)c1ccc2ccccc2c1,,CCO,,,,val
US20120184557A1,CSc1nc(N(C)c2ccccc2)n2ncc(C(C)C)c2n1.NCc1ccc(-c2ccccn2)cc1>>CSc1nc(NCc2ccc(-c3ccccn3)cc2)n2ncc(C(C)C)c2n1,,CCO,,,,val
US20100029626A1,CN1CCN(Cc2ccc(N)cc2)CC1.O=C(Cl)c1cccc2cc(Oc3cc(Cl)ncn3)ccc12>>CN1CCN(Cc2ccc(NC(=O)c3cccc4cc(Oc5cc(Cl)ncn5)ccc34)cc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US05190956,CN1C(=O)C(=NO)C(=O)c2ccccc21>>Cn1c(=O)c(O)c(O)c2ccccc21,[Pd],Cl,,CCO,[H][H],val
US20130017194A1,CC(C)(C)OC(=O)N1CCN(Cc2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1>>NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(CN3CCNCC3)cc2)ncc1C(F)(F)F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080175814A1,Nc1cccc(Nc2ccncc2)c1.O=C(O)c1ccc([N+](=O)[O-])cc1>>O=C(Nc1ccc([N+](=O)[O-])cc1)c1cccc(Nc2ccncc2)c1,CN(C)C=O,C1COCCO1,,O=S(Cl)Cl,c1ccncc1,val
US20060111362A1,CC#CCn1c(=O)n(C)c2ccnc(Cl)c21.CC(C)(C)OC(=O)N1CCNCC1>>CC#CCn1c(=O)n(C)c2ccnc(N3CCN(C(=O)OC(C)(C)C)CC3)c21,,CN1CCCC1=O,,CCOC(C)=O,O,val
US20150284367A1,CC(C)C[C@H](C(N)=O)N(Cc1ccccc1)Cc1ccccc1>>CC(C)C[C@H](CN)N(Cc1ccccc1)Cc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140031391A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1ccc2c(n1)CCCC2NCCc1cc(F)ccc1O>>CCOC(=O)c1ccc2c(n1)CCCC2N(CCc1cc(F)ccc1O)C(=O)OC(C)(C)C,,ClCCl,,,,val
US20150252008A1,Clc1ncccn1.Nc1ncc(-c2ccc(C3CCC3)c(O)c2F)cn1>>Nc1ncc(-c2ccc(C3CCC3)c(Oc3ncccn3)c2F)cn1,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110257151A1,CC1(C)Cc2cc(C(=O)O)ccc2NC1c1cc(F)cc(N2CCCC2=O)c1.CS(N)(=O)=O>>CC1(C)Cc2cc(C(=O)NS(C)(=O)=O)ccc2NC1c1cc(F)cc(N2CCCC2=O)c1,CN(C)c1ccncc1,ClCCl,,,,val
US20120149691A1,COc1ccc(C(C)(C)N)cc1OC.N#Cc1cnn2cccc2c1Cl>>COc1ccc(C(C)(C)Nc2c(C#N)cnn3cccc23)cc1OC,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20060160801A1,CCOC(=O)CC(C)=O.NC(=O)Nc1cccc(C(F)(F)F)c1.O=Cc1cccc([N+](=O)[O-])c1>>CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)NC1c1cccc([N+](=O)[O-])c1,,C1COCCO1,,CN(C)C=O,,val
US04978665,CCCOc1cc(CNC)ccc1OC.O=c1[nH]ncc(Br)c1Br>>CCCOc1cc(CN(C)c2cn[nH]c(=O)c2Br)ccc1OC,,CCO,,,,val
US20020013460A1,CCN1CCN(c2nc(-c3ccc(C=O)cc3)cc3sccc23)CC1.CC[Mg]Br>>CCC(O)c1ccc(-c2cc3sccc3c(N3CCN(CC)CC3)n2)cc1,,C1CCOC1,,CCOCC,[Cl-].[NH4+],val
US20040143115A1,CC(C)(C)OC(=O)N1CCCCC1CN.Clc1nc2ccccc2o1>>CC(C)(C)OC(=O)N1CCCCC1CNc1nc2ccccc2o1,,C1CCOC1,,CCN(CC)CC,,val
US20110224188A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)NC1(c2ccccn2)CC1.Cl.ClCCl>>C[C@H](N)C(=O)NC1(c2ccccn2)CC1.Cl.Cl,,ClCCl,,C1COCCO1,,val
US20050239843A1,COc1cccc(C(=O)CBr)c1>>O=C(CBr)c1cccc(O)c1,,ClCCl,,BrB(Br)Br,,val
US20160272617A1,Cc1cc(C(=O)N[C@H]2CCN(C(=O)OC(C)(C)C)C2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1.Cl>>Cc1cc(C(=O)N[C@H]2CCNC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1.Cl,,C1COCCO1,,,,val
US20090270417A1,COCCCOc1cc(C[C@@H](C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN(C(=O)OC2CCOCC2)C2CC2)C(C)C)ccc1OC>>COCCCOc1cc(C[C@@H](C[C@@H]2CNC[C@H]2CN(C(=O)OC2CCOCC2)C2CC2)C(C)C)ccc1OC,,Cl,,C1COCCO1,,val
US20060160794A1,Clc1ccccc1C1CCCN1.O=C(O)c1nnn(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1Cl>>O=C(c1nnn(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1Cl)N1CCCC1c1ccccc1Cl,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US20090042933A1,BrCC=Cc1ccccc1.OCC(F)(F)C(F)(F)CO>>OCC(F)(F)C(F)(F)COC/C=C/c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US06200963B1,COc1ccc(N=Nc2c(S(=O)(=O)OC(C)C)cc3cc(NC(=O)c4cc(OC)cc(OC)c4)ccc3c2O)cc1>>COc1ccc(N=Nc2c(S(=O)(=O)O)cc3cc(NC(=O)c4cc(OC)cc(OC)c4)ccc3c2O)cc1,,CCC(C)=O,,[I-].[Na+],,val
US20030060633A1,CC(C)(C)OC(=O)CC(=O)CC(O)CCc1ccccc1>>O=C1CC(=O)OC(CCc2ccccc2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05001125,Cc1cc(C)cc(O)c1.Clc1ccc(-n2ccnc2)nn1>>Cc1cc(C)cc(Oc2ccc(-n3ccnc3)nn2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20110130380A1,COC1(C#N)CCOCC1>>COC1(CN)CCOCC1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20040157886A1,O=C(CCl)Nc1ccc2c(c1)OCC(=O)N2.c1ccc(COC2CCNCC2)cc1>>O=C(CN1CCC(OCc2ccccc2)CC1)Nc1ccc2c(c1)OCC(=O)N2,,CCOCC,,,,val
US04612329,COc1ccc(C(C#N)(CCC=O)C(C)C)cc1OC.COc1ccc(OCCN)cc1>>COc1ccc(OCCNCCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1,,CCO,,[BH4-].[Na+],,val
US04316839,CNCC(=O)O.O=c1[nH]c2ccsc2c(=O)o1>>CN1CC(=O)Nc2ccsc2C1=O,,CCOC(C)=O,CS(C)=O,,,val
US20100240642A1,CCOC(=O)c1c(-c2ccc(C(C)(C)C)cc2)c2ccccc2n1Cc1cccc(-c2ccc(OCc3ccccc3)cc2)c1>>CC(C)(C)c1ccc(-c2c(C(=O)O)n(Cc3cccc(-c4ccc(O)cc4)c3)c3ccccc23)cc1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20160075686A1,CC1(C)NC(=O)c2ccc(Cl)cc21.Ic1cncc(I)c1>>CC1(C)c2cc(Cl)ccc2C(=O)N1c1cncc(I)c1,[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20080293737A1,COC(=O)NS(=O)(=O)c1ccc(N)cc1.O=C=NCc1ccc(Cl)c(Cl)c1>>COC(=O)NS(=O)(=O)c1ccc(NC(=O)NCc2ccc(Cl)c(Cl)c2)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20090082339A1,C1CCNCC1.CN(C)[C@@H]1CCN(c2ccc(-n3cnc4cc(Br)sc4c3=O)cc2)C1>>CN(C)[C@@H]1CCN(c2ccc(-n3cnc4cc(N5CCCCC5)sc4c3=O)cc2)C1,,CCOC(C)=O,,O,,val
US20090143455A1,Nc1ccc(F)cc1Cl.O=c1c2c(Cl)cnn2c(=O)c2c(Cl)cnn12>>O=C(Nc1ccc(F)cc1Cl)c1n[nH]cc1Cl,,CCCCC,,,,val
US20150335646A1,C=CCI.O=c1[nH]c2ccccc2c(=O)o1>>C=CCn1c(=O)oc(=O)c2ccccc21,,CC(=O)N(C)C,,Cl,[H-].[Na+],val
US06143764,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Nc1c(F)cc(F)cc1F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(F)cc(F)cc4F)cc3)c2cc1OC,,CCN(CC)CC,Cc1ccccc1,O=C([O-])O.[Na+],,val
US20140221347A1,CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)c1nc(Br)c(NC(=O)C(F)(F)F)cc1Br.O=C(O)C(F)(F)F>>N[C@@H](Cc1cc(F)cc(F)c1)c1nc(Br)c(NC(=O)C(F)(F)F)cc1Br.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04743685,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.COC(O)c1cc(=O)c(OCc2ccccc2)c[nH]1>>CCOC(=O)C=Cc1cc(=O)c(OCc2ccccc2)c[nH]1.O=P(c1ccccc1)(c1ccccc1)c1ccccc1,,C1COCCO1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080167307A1,CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCO)cs1>>CCOC(=O)C(C)(C)Sc1nc(CCO)cs1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020143034A1,CC(C)(C)OC(=O)N(C[C@H](O)COc1ccccc1)[C@@](C)(O)Cc1ccc(Oc2ncccc2C=O)cc1>>CC(C)(C)OC(=O)N(C[C@H](O)COc1ccccc1)[C@H](CO)Cc1ccc(Oc2ncccc2CO)cc1,,CO,,O,[BH4-].[Na+],val
US20060205774A1,CS(=O)(=O)Cl.O=C(C1CCOCC1)N1CCC(c2ccc(OCCCO)cc2)CC1>>CS(=O)(=O)OCCCOc1ccc(C2CCN(C(=O)C3CCOCC3)CC2)cc1,,ClCCl,,CCN(CC)CC,,val
US20130005743A1,COc1ccc(-n2nc(C)c3c(C(=O)O)cc(C)nc32)cc1.Cc1ccnc(C)c1N>>COc1ccc(-n2nc(C)c3c(C(=O)Nc4c(C)ccnc4C)cc(C)nc32)cc1,,c1ccncc1,,O=P(Cl)(Cl)Cl,,val
US05716965,CCN(CC)C(=O)[C@H]1CN2CC[C@@H]1[C@H](NCc1cc(OC)ccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1>>CCN(CC)C[C@@H]1CN2CC[C@H]1[C@@H](NCc1cc(OC)ccc1OC)[C@H]2C(c1ccccc1)c1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20100190783A1,CC(=O)O.COc1cc(C(Nc2ccc(-c3noc(C)n3)cc2)c2nn(-c3ncccn3)c(=O)[nH]2)cc2c1OCOC2.COc1cc(F)c(C(Nc2ccc(C(=N)N)cc2)c2nn(-c3ccccc3C(=O)O)c(=O)[nH]2)cc1OC>>CC(=O)O.COc1cc(C(Nc2ccc(C(=N)N)cc2)c2nn(-c3ncccn3)c(=O)[nH]2)cc2c1OCOC2,[Fe],CO,,O,O=C(O)C(F)(F)F,val
US20140031360A1,CC(C)(C)OC(=O)N1CCC2(CC2)[C@@H](Oc2cncc(-c3nn(C4CCCCO4)c4ccc(Br)cc34)n2)C1.CCCC[Sn](CCCC)(CCCC)c1cncn1C>>Cn1cncc1-c1ccc2c(c1)c(-c1cncc(O[C@H]3CN(C(=O)OC(C)(C)C)CCC34CC4)n1)nn2C1CCCCO1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20090247526A1,Cc1ccc(N)c(Cl)n1.S=C(Cl)Cl>>Cc1ccc(N=C=S)c(Cl)n1,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US20090306123A1,NC1CC1.O=Cc1cccc(C(F)(F)F)c1Cl>>FC(F)(F)c1cccc(CNC2CC2)c1Cl,,CO,,[Na+].[OH-],,val
US20020007059A1,CCOC(=O)CC(=O)COC(C)=O.Cn1[nH]c(=O)cc1N.O=Cc1ccc(F)c(Br)c1>>CCOC(=O)C1=C(COC(C)=O)Nc2c(c(=O)[nH]n2C)C1c1ccc(F)c(Br)c1,,CCO,,,,val
US05665718,CCNCC.O=C1c2c(Cl)cccc2-n2cnc(-c3noc(CCl)n3)c2[C@@H]2CCCN12>>CCN(CC)Cc1nc(-c2ncn3c2[C@@H]2CCCN2C(=O)c2c(Cl)cccc2-3)no1,,CN(C)C=O,,,,val
US20020006936A1,BrP(Br)Br.COc1cc(CO)ccc1C>>COc1cc(CBr)ccc1C,,CCOCC,,,,val
US20160157491A1,C=Cc1ccc2c([N+](=O)[O-])c(Nc3ccc(SC(F)(F)F)cc3)ccc2c1>>C=Cc1ccc2c(N)c(Nc3ccc(SC(F)(F)F)cc3)ccc2c1,[Fe],CCO,,O,[Cl-].[NH4+],val
US20070043063A1,CC(C)(C)[Si](C)(C)Cl.Clc1cnc2[nH]ccc2c1>>CC(C)(C)[Si](C)(C)n1ccc2cc(Cl)cnc21,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US04952573,CCOC(=O)Cl.CCOC(=O)c1ccccc1N>>CCOC(=O)Nc1ccccc1C(=O)OCC,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US04960776,CN(C)CCCNC(=O)N1CCN(c2ccccc2)CC1.NCCN1CCCCC1.c1ccc(N2CCNCC2)cc1>>O=C(NCCN1CCCCC1)N1CCN(c2ccccc2)CC1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US07285557B2,COc1cc([N+](=O)[O-])ccc1OCCBr.FC1CCNC1>>COc1cc([N+](=O)[O-])ccc1OCCN1CCC(F)C1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US05686445,Nc1ccc(C(=O)N2Cc3ccccc3Cc3ccccc32)cc1.O=C(Cl)c1cc(Cl)cc(Cl)c1>>O=C(Nc1ccc(C(=O)N2Cc3ccccc3Cc3ccccc32)cc1)c1cc(Cl)cc(Cl)c1,,ClCCl,,CCN(CC)CC,,val
US05310951,C=CCc1c(OCCCOc2ccc3c(c2CCC)OC(CCC(=O)OC)CC3)ccc(C(=O)NC)c1OC>>C=CCc1c(OCCCOc2ccc3c(c2CCC)OC(CCC(=O)O)CC3)ccc(C(=O)NC)c1OC,,CO,,[Li+].[OH-],,val
US20080161294A1,CCI.CCOCCNC(=O)OC(C)(C)C>>CCOCCN(CC)C(=O)OC(C)(C)C,,CN(C)C=O,,O,[H-].[Na+],val
US05610144,CCOC(=O)CC(NC(=O)NCC(=O)N1C(C(=O)OC(C)(C)C)CCC1c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)C1CCC(c2ccccc2)N1C(=O)CNC(=O)NC(CC(=O)O)c1ccccc1,,CO,O,[K+].[OH-],,val
US04788181,COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1>>COc1ccc(C(OC[C@H]2O[C@@H](n3cnc(N)nc3=O)[C@H](O)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1,,c1ccncc1,,,,val
US20100144695A1,CC(C)O.O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(O)(c3ccc(F)nc3)CC2)C1>>CC(C)Oc1ccc(C2(O)CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20060211697A1,COc1cc(C)ccc1Oc1ccc([N+](=O)[O-])cc1>>Cc1ccc(Oc2ccc([N+](=O)[O-])cc2)c(O)c1,,ClCCl,,BrB(Br)Br,,val
US20030069284A1,COC(=O)c1cc(OC)c(NC(=O)Nc2cnc(C)cn2)cc1C(F)(F)F>>COc1cc(C(=O)O)c(C(F)(F)F)cc1NC(=O)Nc1cnc(C)cn1,,O,,CO,[Li+].[OH-],val
US20080188454A1,CN1CCN(c2ccc(N/C(=N/C#N)Oc3ccccc3)cc2)CC1.NNc1ccc2c(n1)CCCCCC2>>CN1CCN(c2ccc(Nc3nc(N)n(-c4ccc5c(n4)CCCCCC5)n3)cc2)CC1,,CC(C)O,,,,val
US20060089371A1,COC(=O)[C@H](Cc1ccccc1)Nc1cc(-c2ccc(CCc3ccccc3)cc2)ncn1>>O=C(O)[C@H](Cc1ccccc1)Nc1cc(-c2ccc(CCc3ccccc3)cc2)ncn1,,CO,,[Na+].[OH-],,val
US05623005,Oc1cc(N2CCCC2)c2ccccc2c1Cl>>Oc1cc(N2CCCC2)c2ccccc2c1,[Pd],[K+],[OH-],[H][H],,val
US20050245530A1,COc1ccc(CNc2cc(Oc3ccc(NC(=O)NC(=O)Cc4ccc(F)cc4)cc3F)ncn2)cc1.NC(=O)c1cc(Oc2ccc(N)cc2F)ccn1>>NC(=O)c1cc(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)cc2F)ccn1,,CN(C)C=O,ClCCl,,,val
US20100022538A1,Nc1nc(O)ncc1F.O=S(=O)(Cl)c1ccccc1>>Nc1nc(OS(=O)(=O)c2ccccc2)ncc1F,,c1ccncc1,,,,val
US20080009515A1,CCOC(=O)c1cnc(N)c2c(COc3cc(-c4cn(Cc5ccc(Cl)cc5)nn4)ccc3C)csc12.NCCO>>Cc1ccc(-c2cn(Cc3ccc(Cl)cc3)nn2)cc1OCc1csc2c(C(=O)NCCO)cnc(N)c12,,CS(C)=O,,,,val
US20080004312A1,COC(=O)C1(Cc2ccccc2)CCN(C(=O)OC(C)(C)C)CC1>>COC(=O)C1(Cc2ccccc2)CCNCC1,,C1CCOC1,ClCCl,,,val
US20040082570A1,CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)C(CO)C1>>CC(C)(C)OC(=O)N1CCNC(CO)C1,,CCO,,[Na+].[OH-],,val
US04914112,CC(c1ccc(-c2ccccc2)c(F)c1)c1csc(N)n1.CN=C=O>>CNC(=O)Nc1nc(C(C)c2ccc(-c3ccccc3)c(F)c2)cs1,,ClC(Cl)Cl,,,,val
US20080058335A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCC1CCCOC1>>Cc1ccc(S(=O)(=O)OCC2CCCOC2)cc1,,ClCCl,c1ccncc1,,,val
US06235736B1,COc1ccc(N)cc1OC1CCCC1.O=C1CCC(=O)C1>>COc1ccc(NC2=CC(=O)CC2)cc1OC1CCCC1,Cc1ccc(S(=O)(=O)O)cc1,c1ccccc1,,O,,val
US20140107194A1,CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.CCOC(=O)c1ccc(C[C@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@@H]2O)cc1>>CCOC(=O)c1ccc(C[C@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@@H]2OC(=O)[C@@H](N)CC(C)C)cc1,CN(C)c1ccncc1,CCOC(C)=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20140094450A1,COC(=O)c1ccc(NC2CCCC2C)c([N+](=O)[O-])c1>>COC(=O)c1ccc(NC2CCCC2C)c(N)c1,[Pd],CO,,,,val
US20060287363A1,Nc1cc(N)cc(F)c1.O=C(Cl)c1ccc(F)cc1>>Nc1cc(F)cc(NC(=O)c2ccc(F)cc2)c1,,C1CCOC1,,CCN(CC)CC,,val
US20140148340A1,FC(F)(F)Oc1ccc(I)cc1.Oc1cccc2cccnc12.c1c[nH]nn1>>C1=CN(c2ccccc2)NN1c1ccccc1,[Cu]I,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04595535,CCOC(=O)c1nc(Cc2ccccc2[N+](=O)[O-])n[nH]1>>CCOC(=O)c1nc(Cc2ccccc2N)n[nH]1,O=[Pt],CCO,,,,val
US20100160255A1,CC(C)(C)OC(=O)Nc1sc(-c2ccccn2)cc1C(=O)N1CCC(N2CCCC3(CC(=O)N(C4CCC4)C3=O)C2)CC1>>Nc1sc(-c2ccccn2)cc1C(=O)N1CCC(N2CCCC3(CC(=O)N(C4CCC4)C3=O)C2)CC1,,O=C(O)C(F)(F)F,,O=C([O-])[O-].[K+].[K+],,val
US04210758,Nc1nnn[nH]1.O=C(O)c1c[nH]c2c(=O)oc3ccccc3c2c1=O>>O=C(Nc1nnn[nH]1)c1c[nH]c2c(=O)oc3ccccc3c2c1=O,,CN(C)C=O,,O,O=C(n1ccnc1)n1ccnc1,val
US05334709,CCO.COc1nc(Cl)nc(Cl)n1>>CCOc1nc(Cl)nc(OC)n1,,CC(C)=O,,O=C([O-])O.[Na+],,val
US20130079328A1,CC(=O)N1CCN(c2ccc(C(=O)O)nc2)CC1.CCN(C(C)C)C(C)C.NCc1ccc(-c2ccnc(C(F)(F)F)c2)nc1>>CC(=O)N1CCN(c2ccc(C(=O)NCc3cnc(-c4ccnc(C(F)(F)F)c4)c(C)c3)nc2)CC1,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20120322842A1,CC(C)OB1OC(C)(C)C(C)(C)O1.COc1ccc(Br)cc1CCN(C)C>>COc1ccc(B2OC(C)(C)C(C)(C)O2)cc1CCN(C)C,,C1CCOC1,,[Li]CCCC,,val
US20130331374A1,CC1(C)C[C@H](N)C[C@@H]2CCCN21.NC(=O)c1cnc(Cl)nc1Cl>>CC1(C)C[C@H](Nc2nc(Cl)ncc2C(N)=O)C[C@@H]2CCCN21,,CC(C)O,,,,val
US20100234367A1,O=C1C=CCC1.c1cn[nH]c1>>O=C1CCC(n2cccn2)C1,,ClCCl,,O,,val
US20040024261A1,CC1(C)OC[C@H](CCOCc2ccccc2)O1>>OC[C@@H](O)CCOCc1ccccc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140364413A1,CCOC(=O)Cl.CS(N)(=O)=O>>CCOC(=O)NS(C)(=O)=O,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20160264548A1,CC(C)(C)OC(=O)NC1CCCN(c2cnc(Oc3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2)C1>>NC(=O)c1cc(N2CCCC(N)C2)cnc1Oc1ccc(Oc2ccccc2)cc1,,C1COCCO1,ClCCl,Cl,,val
US20110201640A1,C/C(C#N)=C1/c2ccc(CCl)cc2COc2ccccc21.CCc1nc(-c2ccccc2)c[nH]1>>CCc1nc(-c2ccccc2)cn1Cc1ccc2c(c1)COc1ccccc1/C2=C(\C)C#N,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20090036420A1,O=C(O)c1cc(C(F)(F)F)c(Cl)nc1C(=O)O>>O=C(O)c1cnc(Cl)c(C(F)(F)F)c1,,C1COCCO1,,,,val
US20140275043A1,CC(C)(C)OC(=O)NCCC(=O)c1cccc(S(=O)(=O)CC2CCS(=O)(=O)CC2)c1>>NCCC(=O)c1cccc(S(=O)(=O)CC2CCS(=O)(=O)CC2)c1,,ClCCl,,C1COCCO1,Cl,val
US20090264445A1,CCOc1ccc(F)c(B(O)O)c1F.OO>>CCOc1ccc(F)c(O)c1F,,C1CCOC1,,CC(=O)O,,val
US20030236258A1,CS(=O)(=O)c1ccc(NN)nc1.O=C(CC(=O)C(F)(F)F)c1ccc(Cl)cc1Cl>>CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(Cl)cc2Cl)nc1,,OCC(F)(F)F,,O=S(=O)(O)O,,val
US20040209905A1,COc1cc2ncnc(Oc3ccc(N)c(Cl)c3)c2cc1OC.NCc1ccc(F)cc1F.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)NCc4ccc(F)cc4F)c(Cl)c3)c2cc1OC,,CCN(CC)CC,ClC(Cl)Cl,,,val
US20030195230A1,CC(C)(C)c1ccc(NC(=O)c2cccnc2Nc2ccc3cn[nH]c3c2)cc1[N+](=O)[O-]>>CC(C)(C)c1ccc(NC(=O)c2cccnc2Nc2ccc3cn[nH]c3c2)cc1N,,CCO,,,,val
US20080255092A1,CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(CCl)c2CC1.SCc1ccccn1>>CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(CSCc3ccccn3)c2CC1,,CN(C)C=O,O,[H-].[Na+],,val
US20020013310A1,CC(=O)O.O=C(N[C@H]1CCN(CCn2ccc3cnccc32)C1=O)OCc1ccccc1>>CC(=O)O.N[C@H]1CCN(CCn2ccc3cnccc32)C1=O,[Pd],CC(=O)O,,CO,,val
US04568765,CC(=O)NCCN(CCN(CCN(C/C=C(\C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(C)=O)C(C)=O)C(C)=O>>CCNCCN(CC)CCN(CC)CCN(CC)C/C=C(\C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20120046304A1,CC(O)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)cc1)OC31CCOCC1)[C@@H](OC(C)(C)C(C)(C)C)CC(C)(C)C2.CI>>COC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)cc1)OC31CCOCC1)[C@@H](OC(C)(C)C(C)(C)C)CC(C)(C)C2,,C1CCOC1,,,,val
US20060040923A1,O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)c(Cl)c1.O=C=Nc1ccc(Cl)cc1>>O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2NC1=O,,C1CCOC1,,CCN(CC)CC,,val
US20110136763A1,Cc1cc(OS(C)(=O)=O)cc2c1C(CC(=O)[O-])OB2O>>Cc1cc(OS(C)(=O)=O)cc2c1C(CC(=O)O)OB2O,,CCO,,Cl,[Li+].[OH-],val
US05049671,C1COCCN1.Nc1nc(Cl)c2ncn([C@H]3C=C[C@@H](CO)C3)c2n1>>Nc1nc(N2CCOCC2)c2ncn([C@H]3C=C[C@@H](CO)C3)c2n1,,CCO,,[Na+].[OH-],,val
US20050227987A1,CC(=O)c1ccc(N)cc1.COc1ccc(C(=O)Cl)cc1>>COc1ccc(C(=O)Nc2ccc(C(C)=O)cc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20080207660A1,CCc1nn(C2CCCC2)c2cc(-c3ccnn3-c3ccc(C(=O)O)cc3)ccc12.CNOC.O=C(n1ccnc1)n1ccnc1>>CON(C)C(=O)c1ccccc1,,CCOC(C)=O,ClCCl,Cl,O,val
US20110230459A1,CCOC(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1.N#CCBr>>CCOC(=O)C(CC#N)(c1ccc(Cl)cc1)c1ccc(Cl)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20080207891A1,CC(=O)OC[C@H]1O[C@@H](n2cnc3c(Cl)nc(Cl)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O.CCCCc1ncc[nH]1>>CCCCc1nccn1-c1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O,,CC#N,,,,val
US06002008,C=CC(=O)Cl.N#Cc1cccc(Nc2c(C#N)cnc3ccc(N)cc23)c1>>C=CC(=O)Nc1ccc2ncc(C#N)c(Nc3cccc(C#N)c3)c2c1,,CN(C)C=O,,C1CCOC1,CCN(CC)CC,val
US20130060041A1,CCNC(=NS(=O)(=O)c1ccc(NC(=O)C(F)(F)F)c(Br)c1)N1CC(C)(C)C=N1>>CCNC(=NS(=O)(=O)c1ccc(N)c(Br)c1)N1CC(C)(C)C=N1,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US20070219230A1,C#CCBr.Cc1[nH]c2c(N3CCc4ccccc4C3)nccc2c1C.Cl>>C=C=Cn1c(C)c(C)c2ccnc(N3CCc4ccccc4C3)c21.Cl,,C1CCOC1,,[H-].[Na+],,val
US20150291577A1,COC(=O)c1cc(O)n(C)n1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1cc(OS(=O)(=O)C(F)(F)F)n(C)n1,,O,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20120264923A1,COC(=O)CC=C(C)CCCC(C)CCCC(C)C.O=C1O[C@H]([C@@H](O)CO)C(O)=C1O>>CC(=CCC(=O)OC1=C(O)[C@@H]([C@@H](O)CO)OC1=O)CCCC(C)CCCC(C)C,,O=S(=O)(O)O,,O,,val
US20060211730A1,COC(=O)C1(C)COCCC1=O.C[C@@H](N)c1ccccc1>>COC(=O)C1(C)COCCC1=N[C@H](C)c1ccccc1,,Cc1ccccc1,,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US20080176883A1,CC(=O)OC(C)=O.Nc1ccccc1C1CCN(C2CCN(C(=O)CNC(=O)c3ccc(Cl)c(Cl)c3)C2)CC1>>CC(=O)Nc1ccccc1C1CCN(C2CCN(C(=O)CNC(=O)c3ccc(Cl)c(Cl)c3)C2)CC1,,ClCCl,,CCN(CC)CC,,val
US07060425B1,COC(=O)CCCC(C)(C)c1ccc(O)c(C(C)C)c1.O=CC(=O)O>>COC(=O)CCCC(C)(C)c1cc(C(C)C)c2c(c1)C(O)C(=O)O2,,ClCCCl,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080045528A1,COc1ccc2nc(N[C@H]3CCCN(C(=O)OC(C)(C)C)C3)sc2c1>>COc1ccc2nc(N[C@H]3CCCNC3)sc2c1,,C1COCCO1,CO,Cl,,val
US04559354,CC(=O)c1nc(-c2ccc(OCC(O)CN(CCOc3ccc(O)c(C(N)=O)c3)Cc3ccccc3)cc2)n(C)c1C>>CC(=O)c1nc(-c2ccc(OCC(O)CNCCOc3ccc(O)c(C(N)=O)c3)cc2)n(C)c1C,[Pd],CO,,[H][H],,val
US20020133037A1,COc1ccc(C=CC=O)cc1O>>COc1ccc(CCC=O)cc1O,,CO,,,,val
US20080171769A1,CSCCCl.Cc1ccc(OC[C@H](O)CNc2cc[nH]c(=O)c2-c2nc3cc4c(cc3[nH]2)C(=O)N(C2CCNCC2)C4)c(C)c1>>CSCCN1CCC(N2Cc3cc4nc(-c5c(NCC(O)COc6ccc(C)cc6C)cc[nH]c5=O)[nH]c4cc3C2=O)CC1,,CC#N,,[I-].[Na+],,val
US20130116262A1,Nc1cc(Cl)cc(Br)c1N.O=CO>>Clc1cc(Br)c2nc[nH]c2c1,,O=CO,,O=C([O-])[O-].[Na+].[Na+],,val
US20100120763A1,BrCc1ccccc1.O=[N+]([O-])c1c(F)cc(O)cc1F>>O=[N+]([O-])c1c(F)cc(OCc2ccccc2)cc1F,,CCCCCC,CN(C)C=O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20070072897A1,CC1(C)C(=O)N([C@@H](c2cc(F)cc(F)c2)[C@H](O)CO)c2c(F)cccc21.c1ccncc1>>CNC[C@@H](O)[C@H](c1cc(F)cc(F)c1)N1C(=O)C(C)(C)c2cccc(F)c21,,CCOCC,,Cc1ccc(S(=O)(=O)Cl)cc1,,val
US20100048502A1,COCOc1ccc2ccc(C)nc2c1[N+](=O)[O-].O=[Se]=O>>COCOc1ccc2ccc(C=O)nc2c1[N+](=O)[O-],,C1COCCO1,CO,,,val
US20090137607A1,COC(OC)c1ccc(C(O)Cc2ccccc2)cc1.C[O-].N=C(N)N>>COC(OC)c1ccc(-c2nc(N)ncc2-c2ccccc2)cc1,,CO,,Cl,,val
US20110319394A1,CI.Sc1nc2cnccc2[nH]1>>CSc1nc2cnccc2[nH]1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100093694A1,CCOC(=O)c1cccc(B(O)O)c1.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc([N+](=O)[O-])c(OS(=O)(=O)C(F)(F)F)cc12>>CCOC(=O)c1cccc(-c2cc3c(C(=O)NC)c(-c4ccc(F)cc4)oc3cc2[N+](=O)[O-])c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US05712270,CC(C)(C)c1cc(C(=O)Cl)cc(C(C)(C)C)c1O.CCOC(=O)c1csc(N)n1>>CCOC(=O)c1csc(NC(=O)c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)n1,,C1CCOC1,ClCCl,CCN(CC)CC,CO,val
US08012995B1,C=CCN(CC=C)Cc1ccc(S(=O)(=O)N2CCC(C(=O)N(C)OC)CC2)s1.[Li]CCCCCC>>C=CCN(CC=C)Cc1ccc(S(=O)(=O)N2CCC(C(=O)CCCCCC)CC2)s1,,C1CCOC1,,CCO,Cl,val
US20070249580A1,CC(C)(C)OC(=O)NC1CCCNC1.COC(=O)c1ccccc1F>>COC(=O)c1ccccc1N1CCCC(NC(=O)OC(C)(C)C)C1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20030100764A1,CCCc1nc2c(N)nc3ccccc3c2n1CCCCCCl.C[S-]>>CCCc1nc2c(N)nc3ccccc3c2n1CCCCCSC,,CN(C)C=O,,O,,val
US05831004,CCCCCCCBr.CO.COC(=O)CC(C)=O>>CCCCCC(CC)OC(=O)CC(C)=O,,CO,,[Na],C[O-].[Na+],val
US20050059651A1,COC(=O)c1ccc(OC2C=CCCC2)cc1C(=O)OC>>COC(=O)c1ccc(OC2CCCCC2)cc1C(=O)OC,[Pd],C1CCOC1,,,,val
US20080214448A1,COc1ccccc1C#N.NO>>COc1ccccc1C(=N)NO,,CCO,,Cl,[K+].[OH-],val
US20150111887A1,C[Mg]Br.Cn1cc(-c2cc3c(N4CCN(c5ncc(/C(=N\[S@@](=O)C(C)(C)C)c6ccc(F)cc6)cn5)CC4)ncnn3c2)cn1>>Cn1cc(-c2cc3c(N4CCN(c5ncc(C(C)(N[S@@](=O)C(C)(C)C)c6ccc(F)cc6)cn5)CC4)ncnn3c2)cn1,,C1CCOC1,,[Cl-].[NH4+],,val
US20070238700A1,Nc1cccc2c1C(=O)CCC2.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C1CCCc2cccc(NS(=O)(=O)C(F)(F)F)c21,,ClCCl,,,,val
US20160251456A1,Cc1cc(C)c(Cn2ccnc2C)c(C)c1C=O.NO>>Cc1cc(C)c(Cn2ccnc2C)c(C)c1C=NO,,CCO,,,,val
US20060111375A1,COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1OCCCCl.O=C([O-])[O-].c1c[nH]cn1>>COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1OCCCC(=O)n1ccnc1,,CN(C)C=O,,O,,val
US20090259049A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COCc1cc(OC)c(-c2csc3c(N)c(OC)nn23)c(OC)c1>>COCc1cc(OC)c(-c2csc3c(NC(=O)OC(C)(C)C)c(OC)nn23)c(OC)c1,,CCCCCCC,CCOC(C)=O,CCN(CC)CC,ClCCl,val
US20100317568A1,BrBr.CC(=O)c1ccc(Cl)c([N+](=O)[O-])c1>>O=C(CBr)c1ccc(Cl)c([N+](=O)[O-])c1,,c1ccccc1,,,,val
US05358942,CCCCCCCCCCCCCCCCC1(O)CN(C)CCO1>>CCCCCCCCCCCCCCCCC(O)CN(C)CCO,,CO,,[BH4-].[Na+],,val
US04223033,Cc1cccc(C(=O)O)n1.c1ccccc1>>Cc1cccc(C(=O)c2ccccc2)n1,,c1ccccc1,,O=C(Cl)C(=O)Cl,,val
US04618683,COC1=CC=CC(C=CC(=O)O)C1>>COc1cccc(CCCO)c1,,C1CCOC1,,B,Cl,val
US20090018103A1,COCCCC[Mg]Cl.CON(C)C(=O)C1CN(C(=O)OC(C)(C)C)CCO1>>COCCCCC(=O)C1CN(C(=O)OC(C)(C)C)CCO1,,C1CCOC1,,,,val
US20100093811A1,CC=CBr.COc1ccc(CN)c(OC)c1.ClCCl>>C=C(C)CNCc1ccc(OC)cc1OC,,O=C([O-])O,[Na+],Cl,,val
US20040014776A1,O=C1c2ccccc2C(=O)N1CCn1cncc1-c1ccnc(Nc2cccc(Cl)c2)n1>>NCCn1cncc1-c1ccnc(Nc2cccc(Cl)c2)n1,,CCO,,NN,O,val
US20130109701A1,CS(=O)(=O)NC(=O)c1cc(F)c(O)cc1F.Clc1ccc(CBr)cc1Cl>>CS(=O)(=O)NC(=O)c1cc(F)c(OCc2ccc(Cl)c(Cl)c2)cc1F,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04393059,CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CCS[C@H]12)c1csc(N)n1.O.[Na+].[OH-]>>CON=C(C(=O)NC1C(=O)N2C(C(=O)[O-])=CCS[C@H]12)c1csc(N)n1.O.O.[Na+],,CCO,O,,,val
US20030119863A1,CCC(C)c1cc(C=O)c2nc(C)c(C)c(OC(C)=O)c2c1>>CCC(C)c1cc(CO)c2nc(C)c(C)c(OC(C)=O)c2c1,,CO,,O,[BH4-].[Na+],val
US20040147562A1,NNC(=O)c1cccnc1.O=C(CC(=O)C(F)(F)F)c1ccc(Cl)cc1>>OC1(C(F)(F)F)CC(c2ccc(Cl)cc2)=NN1Cc1cccnc1,,CCO,Cc1ccccc1,,,val
US20060270686A1,CC(=O)Cl.Nc1cc(Br)cc(C(=O)c2cccnc2)c1>>CC(=O)Nc1cc(Br)cc(C(=O)c2cccnc2)c1,,CC(Cl)Cl,,CCN(C(C)C)C(C)C,O,val
US20150322058A1,CC(O)c1ccc(S(=O)(=O)Nc2ccnn2-c2ccccn2)cc1.CCN(CC)S(F)(F)F>>CC(F)c1ccc(S(=O)(=O)Nc2ccnn2-c2ccccn2)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20130059834A1,C[C@@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(I)nc12)C(=O)N1CC(C#N)C1.Clc1ccc2[nH]ncc2c1>>C[C@@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-n3ncc4cc(Cl)ccc43)nc12)C(=O)N1CC(C#N)C1,[Cu]I,Cc1ccccc1,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20030134853A1,CC(C)(C)[Si](C)(C)Oc1ccc(-c2nc3cc(-c4nn[nH]n4)ccc3n2C2CCCCC2)cc1>>Oc1ccc(-c2nc3cc(-c4nn[nH]n4)ccc3n2C2CCCCC2)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140364432A1,Cc1ccc(-n2nccn2)c(C(=O)N2CC3CCCC3C2CN2C(=O)c3ccccc3C2=O)c1>>Cc1ccc(-n2nccn2)c(C(=O)N2CC3CCCC3C2CN)c1,,CO,,NN,O,val
US20080214598A1,COC(=O)C1=C(c2ccc(OCCO[Si](C)(C)C(C)(C)C)cc2)CCN(C(=O)OC(C)(C)C)C1>>COC(=O)C1CN(C(=O)OC(C)(C)C)CCC1c1ccc(OCCO[Si](C)(C)C(C)(C)C)cc1,,CO,,Cl,,val
US20040259910A1,COc1ccc(F)c(Cc2ncc(CC#N)c3cc(OC)c(OC)cc23)c1.O.[N-]=[N+]=[N-]>>COc1ccc(F)c(C(=O)c2ncc(Cc3nnn[nH]3)c3cc(OC)c(OC)cc23)c1,Cl,Cc1ccccc1,,CCN(CC)CC,,val
US20020161041A1,COCOc1ccc(C2=CC(=NO)CCC2)c(OCOC)c1>>ON=C1C=C(c2ccc(O)cc2O)CCC1,,CO,,,,val
US20140038919A1,COc1ccc(C(=O)Cc2cc(Br)ccn2)cc1.NO>>COc1ccc(C(Cc2cc(Br)ccn2)=NO)cc1,,CO,O,Cl,[Na+].[OH-],val
US20100278835A1,C1CCOC1.NC(=O)c1cccnc1N>>Nc1ncccc1CNC1CC1,,C1CCOC1,,B,CO,val
US06352993B1,COCc1nc(Cl)nc(N2CCc3ccccc3C2)c1C.Cc1cc(F)ccc1N>>COCc1nc(Nc2ccc(F)cc2C)nc(N2CCc3ccccc3C2)c1C.Cl,,CN(C)C=O,,CCN(CC)CC,,val
US20110015157A1,C=CCC(O)(CCCl)c1ccc(F)cc1.CC(C)(C)OC(=O)N1CCC[C@H](N)C1>>C=CCC(O)(CCN[C@H]1CCCN(C(=O)OC(C)(C)C)C1)c1ccc(F)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040171651A1,CC1(C)ON=C(c2ccccc2)N1N.CCc1ccc(C(=O)Cl)cc1>>CCc1cccc(C(=O)NN2C(c3ccccc3)=NOC2(C)C)c1,,O,,CCO,[Na+].[OH-],val
US20060229348A1,CCCN1C(=O)Cc2cc(N3C[C@@H](CN)OC3=O)ccc21.COC(=O)Cl>>CCCN1C(=O)Cc2cc(N3C[C@H](CNC(=O)OC)OC3=O)ccc21,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05100912,COc1ccc(C[C@H]2CCCN2C(=O)C(F)(F)F)cc1OC>>COc1ccc(C[C@H]2CCCN2)cc1OC,,CC(C)O,,Cl,,val
US20050203108A1,O=C(O)CCNC(=O)c1ccc(CN(CC(c2ccccc2)c2ccccc2)C(=O)c2csc3ccc(Cl)cc23)cc1>>O=C(O)CCNC(=O)c1cccc(CN(CC(c2ccccc2)c2ccccc2)C(=O)c2csc3ccc(Cl)cc23)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080114006A1,CNc1ncc2cc(-c3cc(NC(=O)Nc4cnn(C(C)(C)C)c4)c(F)cc3C)c(=O)n(C)c2n1.C[C@H](N)CO>>Cc1cc(F)c(NC(=O)Nc2cnn(C(C)(C)C)c2)cc1-c1cc2cnc(N[C@@H](C)CO)nc2n(C)c1=O,,C1CCOC1,,,,val
US20110201555A1,Cc1noc(C)c1-c1c(C=O)c2cc(F)c(F)cc2n1-c1ccc(O)cc1.NO>>Cc1noc(C)c1-c1c(C=NO)c2cc(F)c(F)cc2n1-c1ccc(O)cc1,,CCO,,Cl,c1ccncc1,val
US20140088075A1,CCn1c(=O)c(-c2cc(N)c(F)cc2I)cc2cnc(NC)cc21.O=C=Nc1ccccc1>>CCn1c(=O)c(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2I)cc2cnc(NC)cc21,,ClCCl,,c1ccncc1,,val
US20160002204A1,C#CCCBr.O=C(Nc1cc[nH]c(=O)n1)OCc1ccccc1>>C#CCCn1ccc(NC(=O)OCc2ccccc2)nc1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20010046975A1,CCN.Cn1cc(C(=O)O)cn1>>CCNC(=O)c1cnn(C)c1,,O,,,,val
US20050277671A1,CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(C(=O)OC(C)(C)C)CCOCC3)CC2)c2ccccc21>>CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(C(=O)O)CCOCC3)CC2)c2ccccc21,,C1CCOC1,,Cl,,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccco2)c1C#N.c1ccc2c(c1)CCNC2>>N#Cc1c(-c2ccco2)nc(N)nc1N1CCc2ccccc2C1,,COCCOC,,,,val
US20090275581A1,CC(C)(C)OC(=O)N1CCC[C@@H](C(=O)c2cccc(F)c2N2CCCCC2)C1.COCCCC[Mg]Cl>>COCCCC[C@@](O)(c1cccc(F)c1N1CCCCC1)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,N#N,,val
US04939259,BrP(Br)Br.CCCN1CCC[C@H]2Cc3[nH]c(=O)ccc3C[C@@H]21>>Br.Br.CCCN1CCC[C@H]2Cc3nc(Br)ccc3C[C@@H]21,,CN(C)C=O,,,,val
US20080280886A1,CC(C)CBr.COC(=O)Cc1ccc(O)cc1>>COC(=O)Cc1ccc(OCC(C)C)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110092497A1,CCCC[Sn](CCCC)(CCCC)c1cnc(N(C(=O)OC(C)(C)C)c2ccc(N3CCOCC3)cc2)c2nccn12.NC(=O)c1ncc(Br)s1>>NC(=O)c1ncc(-c2cnc(Nc3ccc(N4CCOCC4)cc3)c3nccn23)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20060069144A1,S=C(Cl)Oc1ccccc1.c1nc(Cc2ccc3c(c2)OCO3)c[nH]1>>S=c1[nH]cc(Cc2ccc3c(c2)OCO3)[nH]1,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20150126490A1,CC(C)(C)[S@](=O)N[C@H](CN)c1cc(F)cc(Br)c1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CC(C)(C)[S@](=O)N[C@H](CNS(=O)(=O)c1ccccc1[N+](=O)[O-])c1cc(F)cc(Br)c1,,ClCCl,,,,val
US20160257652A1,CC(C)(C)[Si](C)(C)O[C@H]1C[C@@H](O)C1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)O[C@@H]2C[C@H](O[Si](C)(C)C(C)(C)C)C2)cc1,,ClCCl,,CCN(CC)CC,,val
US04515788,CC(C)(C)OC(=O)CON=C(C(=O)OC(c1ccccc1)c1ccccc1)c1csc(NC=O)n1>>CC(C)(C)OC(=O)CON=C(C(=O)OC(c1ccccc1)c1ccccc1)c1csc(N)n1,,CO,O,Cl,O=C([O-])O.[Na+],val
US20110195954A1,Fc1ccc2c(c1)CCN2.O=C(O)c1cc(Cl)ccn1>>O=C(c1cc(Cl)ccn1)N1CCc2cc(F)ccc21,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20050197348A1,CC1CCN(C(=O)Cl)CC1.Oc1n[nH]c2cccc(F)c12>>CC1CCN(C(=O)Oc2n[nH]c3cccc(F)c23)CC1,,c1ccncc1,,,,val
US20040006141A1,BrCCOC1CCCCO1.CCOC(=O)C(C)(CCCc1ccccc1)Cc1ccc(O)cc1>>CCOC(=O)C(C)(CCCc1ccccc1)Cc1ccc(OCCOC2CCCCO2)cc1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20090012093A1,COC(=O)CCc1ccc(OCc2cccc(Cc3c(C)cccc3C)c2)cc1>>Cc1cccc(C)c1Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1,,CCO,,[Na+].[OH-],,val
US20110275611A1,N#Cc1ccc(-c2cc(NC3(Cc4ccccc4)CC3)nc(N)n2)cc1F.NN>>Nc1nc(NC2(Cc3ccccc3)CC2)cc(-c2ccc3c(N)n[nH]c3c2)n1,,CCO,,O,,val
US20150126498A1,COc1ncc(N)cn1.NCc1c(F)cccc1Cl.O=S(=O)(Cl)c1ccccc1F>>COc1ncc(NS(=O)(=O)c2ccccc2NCc2c(F)cccc2Cl)cn1,,C1COCCO1,CC#N,,,val
US20070082912A1,CC(=O)CCC(=O)c1cc(Cl)ccc1OCc1c(F)cccc1F.COC(=O)c1cc(N)cc(C(F)(F)F)c1>>Cc1ccc(-c2cc(Cl)ccc2OCc2c(F)cccc2F)n1-c1cc(C(=O)O)cc(C(F)(F)F)c1,,CC#N,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140206680A1,CCCC[Sn](Cl)(CCCC)CCCC.c1cc2ccsc2cn1>>CCCC[Sn](CCCC)(CCCC)c1cc2ccncc2s1,,C1CCOC1,,[Li]CCCC,O=C([O-])O.[Na+],val
US05179121,O=C(Cl)CCC(F)(F)Cl.SC1CCCCC1>>O=C(CCC(F)(F)Cl)SC1CCCCC1,,CCOCC,Cc1ccccc1,c1ccncc1,,val
US20130316943A1,CCOC(=O)C(Cc1ccc(C(F)(F)F)cc1)(NC(C)=O)C(=O)OCC>>CC(=O)NC(Cc1ccc(C(F)(F)F)cc1)C(=O)O,,CC(C)=O,,[Na+].[OH-],,val
US20060252782A1,C1CCNC1.Nc1cc(SCCCCN2C(=O)c3ccccc3C2=O)cc([N+](=O)[O-])c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(Nc1cc(SCCCCN2C(=O)c3ccccc3C2=O)cc([N+](=O)[O-])c1)N1CCCC1,,ClCCl,,,,val
US20040254205A1,COc1cc2ncnc(Nc3ccccc3)c2c(N)c1OC.O=C(n1ccnc1)n1ccnc1>>COc1cc2ncnc3c2c(c1OC)NC(=O)N3c1ccccc1,,ClCCCl,,,,val
US20120289522A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CS[Si](C(C)C)(C(C)C)C(C)C)cc3)cc2)CC1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CS)cc3)cc2)CC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04628057,CI.S=C=S.c1ccc2c3c([nH]c2c1)CNC(c1nnn[nH]1)C3>>CSC(=S)N1Cc2[nH]c3ccccc3c2CC1c1nnn[nH]1,,CCO,,CCN(CC)CC,,val
US06005000,CCOC(=O)C(C)(O)c1ccc(-c2ccccc2)cc1>>CC(O)(C(=O)O)c1ccc(-c2ccccc2)cc1,,CCO,,[Na+].[OH-],,val
US20100305122A1,CN1CCC(F)(CO)CC1.NS(=O)(=O)c1ccc(F)c(S(=O)(=O)C(F)(F)F)c1>>CN1CCC(F)(COc2ccc(S(N)(=O)=O)cc2S(=O)(=O)C(F)(F)F)CC1,,C1CCOC1,ClCCl,O,[H-].[Na+],val
US20160090577A1,C=CC[Mg]Cl.CCCCCCCCCCCC=O>>C=CCC(O)CCCCCCCCCCC,,ClCCl,,C1CCOC1,Cl,val
US20160016927A1,CC1(C)OB(c2ccc(C#N)c(N)c2)OC1(C)C.O=S(=O)(Oc1ccc2c(c1)CC(c1cc(Cl)cc(Cl)c1)(C(F)(F)F)S2)C(F)(F)F>>N#Cc1ccc(-c2ccc3c(c2)CC(c2cc(Cl)cc(Cl)c2)(C(F)(F)F)S3)cc1N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20050227959A1,CC(=O)c1cc(S(=O)(=O)N(C)CC(O)c2ccc(F)cc2)c(NC(=O)OC(C)(C)C)s1>>CC(=O)c1cc(S(=O)(=O)N(C)CC(O)c2ccc(F)cc2)c(N)s1,,O,,O=C(O)C(F)(F)F,,val
US20150057265A1,CC(C)(C)OC(=O)Nc1oc2cc(C3CCOCC3)cnc2c1C(=O)Nc1cnsc1N1C[C@H](C(F)(F)F)C[C@H](NC(=O)OC(C)(C)C)C1>>Nc1oc2cc(C3CCOCC3)cnc2c1C(=O)Nc1cnsc1N1C[C@H](C(F)(F)F)C[C@H](N)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060160872A1,FC(F)(F)c1ccc2[nH]c(Cl)nc2c1.Nc1cccc2cccnc12>>FC(F)(F)c1ccc2[nH]c(Nc3cccc4cccnc34)nc2c1,,CCO,,,,val
US20080242596A1,CCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(COCC(C)=O)cc2Cl)cc1>>CCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(COCC(C)O)cc2Cl)cc1,,C1CCOC1,,CO,[BH4-].[Na+],val
US05547983,O=C(OCc1ccccc1)c1ccc2cc(-c3ccc(OC[C@H](O)CO)c(C45CC6CC(CC(C6)C4)C5)c3)ccc2c1>>O=C(O)c1ccc2cc(-c3ccc(OC[C@H](O)CO)c(C45CC6CC(CC(C6)C4)C5)c3)ccc2c1,,CO,,[Na+].[OH-],,val
US04474792,Nc1nnn[nH]1.O=C(O)c1ccccc1O>>O=C(Nc1nnn[nH]1)c1ccccc1O,,O,,O=S(Cl)Cl,c1ccncc1,val
US20060199829A1,COC(=O)c1cnc(N2CCc3[nH]c4ccc(-c5ccc(C=O)cc5)cc4c3C2)nc1>>COC(=O)c1cnc(N2CCc3[nH]c4ccc(-c5ccc(CO)cc5)cc4c3C2)nc1,,ClCCl,,[BH4-].[Na+],,val
US20070185165A1,COCCc1nonc1C(=NO)Nc1ccc(F)c(Cl)c1.O=C(n1ccnc1)n1ccnc1>>COCCc1nonc1-c1noc(=O)n1-c1ccc(F)c(Cl)c1,,C1CCOC1,,,,val
US20070232627A1,CC(C)c1nc2ncnc(Nc3cc(C(=O)O)ccc3Sc3ccc(NC(=O)OC(C)(C)C)cc3)c2cc1F>>CC(C)c1nc2ncnc(Nc3cc(C(=O)O)ccc3Sc3ccc(N)cc3)c2cc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090275567A1,C=O.Cc1ncc(-c2nc(NC3CCN(S(=O)(=O)C4CCNCC4)CC3)ncc2F)n1C(C)C>>Cc1ncc(-c2nc(NC3CCN(S(=O)(=O)C4CCN(C)CC4)CC3)ncc2F)n1C(C)C,,CO,,[BH3-]C#N.[Na+],,val
US20090023763A1,CCOC(OCC)OCC.CSc1nccc(-c2cc(N)c(N)nc2-c2ccco2)n1>>CSc1nccc(-c2cc3nc[nH]c3nc2-c2ccco2)n1,,O,,,,val
US20030199552A1,Nc1cc2oc(=O)[nH]c2cc1[N+](=O)[O-].O=C(Cl)C(=O)N1CCC(Cc2ccccc2)CC1>>O=C(Nc1cc2oc(=O)[nH]c2cc1[N+](=O)[O-])C(=O)N1CCC(Cc2ccccc2)CC1,,ClC(Cl)Cl,,,,val
US20040023938A1,Cc1ccc(S(=O)(=O)Nc2ccc(F)cc2)cc1.O=[N+]([O-])O>>Cc1ccc(S(=O)(=O)Nc2ccc(F)cc2[N+](=O)[O-])cc1,,CC(=O)O,,O,,val
US04578398,Br[Mg]c1ccccc1.CCC1(CC(=O)OC)CCC=CC1=O>>CCC1(CC(=O)OC)CCC(c2ccccc2)CC1=O,,C1CCOC1,,CSC,,val
US20100093694A1,CC(C)(N)c1ccccc1.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3ccc(Cl)c(C(=O)O)c3)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3ccc(Cl)c(C(=O)NC(C)(C)c4ccccc4)c3)cc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040106667A1,CC(C)(C)OC(=O)n1cccc1B(O)O.CC(C)(C)OC(=O)n1nc(I)c2cc(NS(=O)(=O)c3ccccc3S(C)(=O)=O)ccc21>>CS(=O)(=O)c1ccccc1S(=O)(=O)Nc1ccc2[nH]nc(-c3ccc[nH]3)c2c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20040192930A1,CCOC(=O)C(F)(F)F.c1ccc2c(c1)CCc1cn[nH]c1-2>>O=C1CCCc2ccccc21,,CO,,C[O-].[Na+],,val
US20130053366A1,Cc1ccc2c(c1)c1c(n2CC(OS(C)(=O)=O)c2ccncc2)CCN(C)C1.NC1CCC1>>Cc1ccc2c(c1)c1c(n2CC(NC2CCC2)c2ccncc2)CCN(C)C1,,O,,,,val
US20140213586A1,Nc1cccc(C(F)(F)F)c1.O=C(c1c[nH]c2ccccc12)C(Cl)c1ccccc1>>O=C(c1c[nH]c2ccccc12)C(Nc1cccc(C(F)(F)F)c1)c1ccccc1,,CCO,,CCN(C(C)C)C(C)C,,val
US20090253699A1,COC(=O)c1cccc(-c2cc(-c3ccc(Cl)cc3)on2)c1>>O=C(O)c1cccc(-c2cc(-c3ccc(Cl)cc3)on2)c1,,C1CCOC1,O,Cl,,val
US20020045747A1,CCN(CC)S(F)(F)F.COC(=O)C(O)c1cc(F)cc(F)c1>>COC(=O)C(F)c1cc(F)cc(F)c1,,ClCCl,,,,val
US20050203078A1,COC(=O)c1ccc(N)c(C)c1.O=C(Cl)CCOCCCl>>COC(=O)c1ccc(NC(=O)CCOCCCl)c(C)c1,,C1CCOC1,,CCN(CC)CC,O,val
US04163846,COS(=O)(=O)OC.N#Cc1c(N)n[nH]c1N>>Cn1nc(N)c(C#N)c1N,,[Na+],[OH-],,,val
US20150232420A1,C=CC(=O)Cl.COC(=O)[C@@H]1CC(CCN)CN1C(=O)OC(C)(C)C>>C=CC(=O)NCCC1C[C@@H](C(=O)OC)N(C(=O)OC(C)(C)C)C1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US04277395,CCOC(=O)C(Cc1ccccc1)C(CF)C1(C#N)SCCCS1>>CC(C(=O)O)C(CF)C1(C#N)SCCCS1,,CCO,,[Li+].[OH-],,val
US20060194783A1,BrCC1CC1.O=C1CCCC(c2ccccc2)CN1>>O=C1CCCC(c2ccccc2)CN1CC1CC1,,CN(C)C=O,,[H-].[Na+],,val
US20130158026A1,CC(Nc1cccc(Cl)c1F)c1cc(C(=O)O)cc2c(=O)cc(N3CCOCC3)oc12.CN(C)CCN>>CC(Nc1cccc(Cl)c1F)c1cc(C(=O)NCCN(C)C)cc2c(=O)cc(N3CCOCC3)oc12,,CN1CCCC1=O,,CN1CCOCC1,,val
US20060063785A1,Nc1cccc(-c2ccnc3c(C(=O)c4cccs4)cnn23)c1.O=C(Cl)c1ccccc1F>>O=C(Nc1cccc(-c2ccnc3c(C(=O)c4cccs4)cnn23)c1)c1ccccc1F,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US06262074B1,CC(=O)OC(C)=O.O=C(O)c1ccc2c(c1)NCCC2=O>>CC(=O)N1CCC(=O)c2ccc(C(=O)O)cc21,,O,,,,val
US20140336106A1,COC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)OC(C)(C)C>>COc1ccc(C[C@H](NC(=O)[C@H](COCc2ccccc2)NC(=O)OC(C)(C)C)C(=O)O)cc1,,CCOC(C)=O,O,CO,[Li+].[OH-],val
US20060040961A1,CCN1CCN(CCN)CC1.Clc1ncnc2oc(-c3ccc(OCCN4CCCC4)cc3)c(-c3ccccc3)c12>>CCN1CCN(CCNc2ncnc3oc(-c4ccc(OCCN5CCCC5)cc4)c(-c4ccccc4)c23)CC1,,CC#N,ClCCl,CCN(C(C)C)C(C)C,,val
US20100179125A1,CC(=O)c1cc(-c2ccc(N)cc2)c2c(N)ncnn12.O=C(Nc1cccc(C(F)(F)F)n1)Oc1ccccc1>>CC(=O)c1cc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)n3)cc2)c2c(N)ncnn12,,CN(C)C=O,CS(C)=O,CCN(CC)CC,,val
US05703098,COc1ccc(C(N)CCO)cc1OC.O=C1OC(=O)c2ccccc21>>COc1ccc(C(CCO)N2C(=O)c3ccccc3C2=O)cc1OC,,CCOCC,,,,val
US20110059954A1,Cc1cc(C(=O)c2cc(N3CCC(n4c(=O)[nH]c5ncccc54)CC3)nc(N(C)C(=O)OC(C)(C)C)c2)cc2oc(=O)n(C)c12>>CNc1cc(C(=O)c2cc(C)c3c(c2)oc(=O)n3C)cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04309552,CCN1CC([N+](=O)[O-])CN1CC>>CCN1CC(N)CN1CC,[Ni],Cc1ccccc1,,CCO,,val
US05344843,C1CCOC1.CCOC(=O)N=NC(=O)OCC.COC(=O)C(=O)c1ccc(O)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCC(C)(C)C(=O)OCc1cccc(C)c1/C=C\COc1ccc(C(=O)C(=O)OC)cc1,,C1CCOC1,,,,val
US20120046267A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ncc(I)c2ccoc12>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ncc(I)c2ccoc12,CN(C)c1ccncc1,ClCCl,,O,,val
US20080188528A1,COC(=O)c1cccn(Cc2cccc(-c3ccccc3)c2)c1=O>>O=C(O)c1cccn(Cc2cccc(-c3ccccc3)c2)c1=O,,C1CCOC1,CO,[Na+].[OH-],,val
US06395766B1,CCc1c[nH]c2c1C(=O)CC(C)(C)C2.Fc1ccccn1>>CCc1cn(-c2ccccn2)c2c1C(=O)CC(C)(C)C2,,CN(C)C=O,,[H-].[Na+],,val
US20040142850A1,N#C[Cu].O=c1[nH]c2cc(Br)cc(C(F)(F)F)c2n1Cc1cccc(C(F)(F)F)c1>>N#Cc1cc(C(F)(F)F)c2c(c1)[nH]c(=O)n2Cc1cccc(C(F)(F)F)c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20060199956A1,CC1(C)OCCn2c1nc(C(=O)NCc1ccc(F)cc1I)c(OCc1ccccc1)c2=O.Cn1nccc1B1OC(C)(C)C(C)(C)O1>>Cn1nccc1-c1cc(F)ccc1CNC(=O)c1nc2n(c(=O)c1OCc1ccccc1)CCOC2(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20090221555A1,COCC(=O)Cl.O=[N+]([O-])c1ccc2c(c1)OCCCN2>>COCC(=O)N1CCCOc2cc([N+](=O)[O-])ccc21,CN(C)c1ccncc1,c1ccncc1,,,,val
US20100240658A1,CC1CCCCN1c1ccc(C(=O)O)cc1[N+](=O)[O-].COC(=O)c1ccc(C(N)=NO)cc1F>>COC(=O)c1ccc(-c2noc(-c3ccc(N4CCCCC4C)c([N+](=O)[O-])c3)n2)cc1F,,Cc1ccccc1,ClCCl,,,val
US20150284395A1,CCOC(=O)CC(=O)c1ccc(Cl)c(OCC)c1.Cc1coc(-c2cn[nH]c2N)n1>>CCOc1cc(-c2cc(=O)n3ncc(-c4nc(C)co4)c3[nH]2)ccc1Cl,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090062306A1,CCCCCC(=O)Nc1ncc(OC)cn1>>CCCCCC(=O)Nc1ncc(O)cn1,,ClCCCl,,BrB(Br)Br,CO,val
US20140163010A1,CN.Clc1ncnc2c1cnn2CCN1CCCCCC1>>CNc1ncnc2c1cnn2CCN1CCCCCC1,,CCO,,,,val
US20060223792A1,OCCc1ccccc1.Oc1ccc(OCCBr)cc1>>CC(Br)c1ccc(OCCc2ccccc2)cc1,,ClCCl,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090270460A1,CCOC(=O)CC(C)c1ccc(OCc2c(C(C)C)cnn2-c2c(Cl)cccc2Cl)cc1C>>Cc1cc(OCc2c(C(C)C)cnn2-c2c(Cl)cccc2Cl)ccc1C(C)CCO,,C1CCOC1,CO,[BH4-].[Na+],,val
US20130005716A1,Nc1ccc(S(=O)(=O)N2CCSC2C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)cc1>>Nc1ccc(S(=O)(=O)N2CCS[C@H]2C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)cc1,,CCO,,CS(=O)(=O)O,,val
US20060106035A1,O=c1[nH]c(Cc2cccc(Cl)c2)nc2c1cnn2C1CCCC1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>S=c1[nH]c(Cc2cccc(Cl)c2)nc2c1cnn2C1CCCC1,,c1ccncc1,,O=C([O-])O.[Na+],,val
US20120010244A1,CC(C)(C)C1CC(c2c[nH]c3c(C(N)=O)cc(Br)cc23)CCN1C(=O)[O-].Cl>>Cl.NC(=O)c1cc(Br)cc2c(C3CCNCC3)c[nH]c12,,C1COCCO1,CO,CCOCC,,val
US05411966,CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc(C4SCCS4)cc4[nH]c(C)c(c34)C[C@H]2N(C)C1>>CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc(C)cc4[nH]c(C)c(c34)C[C@H]2N(C)C1,[Ni],CO,,,,val
US20160000760A1,CC(=O)Nc1cc(F)c(-c2ccc(S(C)(=O)=O)cc2)c(Cl)c1>>CS(=O)(=O)c1ccc(-c2c(F)cc(N)cc2Cl)cc1,,CCO,,Cl,,val
US20100048610A1,CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1OS(=O)(=O)C(F)(F)F,,ClCCl,c1ccncc1,O,,val
US04243670,Clc1ccccc1C(Cl)(c1ccccc1)c1ccccc1.c1ccc(-c2ccc(C(c3ccccc3)n3ccnc3)cc2)cc1>>Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cc[n+](C(c2ccccc2)c2ccc(-c3ccccc3)cc2)c1.[Cl-],,CC#N,,,,val
US20140329825A1,CN(Cc1ccncc1)c1ncc(C(N)=NO)cn1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CN(Cc1ccncc1)c1ncc(-c2noc(C(F)(F)F)n2)cn1,,C1CCOC1,,,,val
US20160016933A1,CC(C)(C)OC(=O)c1c(CC#N)cccc1-c1ccccc1>>N#CCc1cccc(-c2ccccc2)c1C(=O)O,,CO,O,Cl,,val
US20160264548A1,CC(C)(C)OC(=O)N1CCCC(Nc2ncc(C(N)=O)c(Oc3ccc(Oc4ccccc4)cc3)n2)C1>>NC(=O)c1cnc(NC2CCCNC2)nc1Oc1ccc(Oc2ccccc2)cc1,,CO,Cl,,,val
US04064239,NCc1ccccc1.NS(=O)(=O)c1cc(S(N)(=O)=O)c(C(Cl)=C(Cl)Cl)cc1Br>>NS(=O)(=O)c1cc(S(N)(=O)=O)c(C(Cl)=C(Cl)Cl)cc1NCc1ccccc1,,CC(=O)O,,,,val
US20110207728A1,COC(=O)c1ccc(Br)[nH]1.COc1ccc(C(=O)CBr)cc1>>COC(=O)c1ccc(Br)n1CC(=O)c1ccc(OC)cc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US06218392B1,COc1ccc(CN)cc1Cl.N#Cc1ccc2c(Cl)nnc(Cl)c2c1>>COc1ccc(CNc2nnc(Cl)c3ccc(C#N)cc23)cc1Cl,,C1CCOC1,,CCN(CC)CC,,val
US20070015758A1,Cc1cccc2cc(CN(C#N)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(N(CC3CC3)CC3CC3)nc12.[N-]=[N+]=[N-].[NH4+]>>Cc1cccc2cc(CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nn[nH]n3)c(N(CC3CC3)CC3CC3)nc12,,CN(C)C=O,,[Cl-].[Na+],,val
US20080176830A1,CC[Mg]Br.COC(=O)Cl.N#Cc1cc(-c2ccc(C(F)(F)F)cc2)ccc1N>>CCC1NC(=O)Nc2ccc(-c3ccc(C(F)(F)F)cc3)cc21,,C1CCOC1,CCO,[BH4-].[Na+],,val
US20050065340A1,COc1cc(C(=O)NC2CCCC[C@H]2O)ccc1CC#N>>COc1cc(C(=O)NC2CCCCC2=O)ccc1CC#N,,ClCCl,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US04507498,CCCc1c(OCCCCCC(=O)OC)ccc(C(C)=O)c1O.CS(=O)(=O)OCCOCCOS(C)(=O)=O>>CCCc1c(OCCCCCC(=O)OC)ccc(C(C)=O)c1OCCOCCOS(C)(=O)=O,,CC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20120316165A1,CC(C)(C)OC(=O)N1CCOC(c2ccc(N=C(c3ccccc3)c3ccccc3)c(F)c2)C1>>CC(C)(C)OC(=O)N1CCOC(c2ccc(N)c(F)c2)C1,,CO,,O=C[O-].[NH4+],,val
US20100048901A1,CNC.O=Cc1ccccc1F>>CN(C)c1ccccc1C=O,,CCOC(C)=O,CN(C)C=O,CCO,O=C([O-])[O-].[K+].[K+],val
US20040192688A1,CCCCCCCCN.ClCCCOc1ccc2ccccc2c1>>CCCCCCCCNCCCOc1ccc2ccccc2c1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120053147A1,CSc1nc(=O)c2sc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1C.O=C(OO)c1cccc(Cl)c1>>Cc1c(Cl)cccc1Cn1c(=O)[nH]c(=O)c2sc(N3CCOCC3)nc21,,ClCCl,,,,val
US20100073621A1,C1CCOC1.COB(OC)OC.[Li]C(C)CC>>OB(O)c1ccccc1,,CCOC(C)=O,,Cl,,val
US20080194576A1,CCOC(=O)N1CCN(C(=O)[C@@H](N)CCC(=O)OC(C)(C)C)CC1.O=C(O)c1cc(Cl)nc(-c2ccccc2)n1>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(Cl)nc(-c3ccccc3)n2)CC1,,CC#N,O,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20100204472A1,CCCc1cc(C(N)=S)ccc1OCCCOc1ccc2c(c1)CC[C@H]2CC(=O)OCC.O=C1CCCCC1Cl>>CCCc1cc(-c2nc3c(s2)CCCC3)ccc1OCCCOc1ccc2c(c1)CC[C@H]2CC(=O)OCC,,CCO,,,,val
US04863945,CC1(C)C(=O)Nc2cc(N)c(N)cc21.O=Cc1c[nH]c2ccccc12>>CC1(C)C(=O)Nc2cc3[nH]c(-c4c[nH]c5ccccc45)nc3cc21,,CC(=O)O,,CO,,val
US05047404,CCCOc1ccccc1C(=O)Nc1ncccc1C(N)=O>>CCCOc1ccccc1-c1nc2ncccc2c(=O)[nH]1,,c1ccncc1,,Cl,[Na+].[OH-],val
US20140142081A1,COc1ccccc1CC(=O)O.Nc1nnc([C@H]2CCC[C@H](c3nnc(NC(=O)Cc4ccccn4)s3)C2)s1>>COc1ccccc1CC(=O)Nc1nnc([C@H]2CCC[C@H](c3nnc(NC(=O)Cc4ccccn4)s3)C2)s1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090054405A1,N#CCCl.Oc1cncc(Br)c1>>N#CCOc1cncc(Br)c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030181496A1,CC(N)=S.CCOC(=O)C(C)C(=O)Cl>>CCOC(=O)c1cnc(C)s1,,CC(C)=O,,,,val
US20160176864A1,CC(C)O.Cc1nnn(C)c1-c1cnc2c3ccc(NC(=O)OCCC(F)(F)F)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1>>Cc1nnn(C)c1-c1cnc2c3ccc(NC(=O)OC(C)C)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1,,CC#N,O,O=C(O)C(F)(F)F,,val
US20100093811A1,CCOC(=O)[C@H](CCC[C@H](C)NC(=O)[C@@H](NC(=O)OC)C(c1ccccc1)c1ccccc1)NC(=O)OC(C)(C)C>>CCOC(=O)[C@@H](N)CCC[C@H](C)NC(=O)[C@@H](NC(=O)OC)C(c1ccccc1)c1ccccc1,,ClCCl,,C1COCCO1,Cl,val
US20120022096A1,Brc1ccc2[nH]c3ccc(Br)cc3c2c1.CCOC(=O)CBr>>CCOC(=O)Cn1c2ccc(Br)cc2c2cc(Br)ccc21,,CCOC(C)=O,CN(C)C=O,[K+].[OH-],,val
US20090247517A1,Cc1nc2c(=O)n(-c3ccc(Cl)cc3)c(-c3ccc(-c4ccccc4)cc3)nc2n1-c1ccccc1.O=C1CCC(=O)N1Br>>O=c1c2nc(CBr)n(-c3ccccc3)c2nc(-c2ccc(-c3ccccc3)cc2)n1-c1ccc(Cl)cc1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20120114739A1,CCOC(=O)CC1CCC(c2nc3c(-c4cnc5ccccc5c4)cnn3c(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)c2Br)CC1.OB(O)c1ccncc1>>Nc1c(-c2ccncc2)c(C2CCC(CC(=O)O)CC2)nc2c(-c3cnc4ccccc4c3)cnn12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130017194A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc(C2CCCCN2)cc1>>CC(C)(C)OC(=O)N1CCCCC1c1ccc(N)cc1,O=[Pt],,,[H][H],,val
US20120316161A1,CCCC(C(=O)OCC)c1c(C)nc2c(Br)cnn2c1-c1ccc(C)cc1.OB(O)c1ccccc1>>CCCC(C(=O)OCC)c1c(C)nc2c(-c3ccccc3)cnn2c1-c1ccc(C)cc1,,COCCOC,O,CCN(C(C)C)C(C)C,,val
US04824834,COCCl.CSc1cc(F)ccc1C>>CSc1cc(F)c(CCl)cc1C,,S=C=S,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20060205731A1,CC(=O)OC(C)=O.Cc1ccnc(Nc2cccc(-c3cnc([C@H](C)N)s3)n2)c1>>CC(=O)N[C@@H](C)c1ncc(-c2cccc(Nc3cc(C)ccn3)n2)s1,,c1ccncc1,,,,val
US20050020587A1,CCOC(=O)c1cccnc1N>>Nc1ncccc1CO,,CCOCC,CCOCC,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06184225B2,CC(=O)OC(C)=O.COc1cc2c(Nc3cc(OCc4ccccc4)c(C)cc3F)ncnc2cc1OCCO>>COc1cc2c(Nc3cc(OCc4ccccc4)c(C)cc3F)ncnc2cc1OCCOC(C)=O,CN(C)c1ccncc1,CCOC(C)=O,,CCN(CC)CC,O,val
US04572912,CC(=O)Oc1c(C)c(C)c2c(c1C)C(=O)CC(C)(COc1ccc([N+](=O)[O-])cc1)O2>>CC(=O)Oc1c(C)c(C)c2c(c1C)C(=O)CC(C)(COc1ccc(N)cc1)O2,[Pd],CO,,[H][H],,val
US20160194331A1,CC(C)(C)OC(=O)NCC(=O)O.NC(=O)[C@@H]1CC[C@@H](N)CO1>>CC(C)(C)OC(=O)NCC(=O)N[C@@H]1CC[C@@H](C(N)=O)OC1,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04772600,CCOC(=O)CNC(=O)Cn1c(-c2ccc(Cl)cc2)nc2cccnc21.[K+].[OH-]>>O.O=C([O-])CNC(=O)Cn1c(-c2ccc(Cl)cc2)nc2cccnc21.[K+],,CCO,,,,val
US20100120860A1,CN(c1nnc(C(F)(F)F)s1)C1CCNCC1.Fc1ccc(CCl)cc1>>CN(c1nnc(C(F)(F)F)s1)C1CCN(Cc2ccc(F)cc2)CC1,,CC#N,ClCCl,CCN(C(C)C)C(C)C,,val
US05254543,Cc1ccc(S(=O)(=O)Cl)cc1.O=C1CCC(=O)N1Br>>BrCc1ccccc1.O=S(=O)(O)Cl,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20100130557A1,CO.O=[N+]([O-])c1cc(Cl)cc([N+](=O)[O-])c1>>COc1cc(Cl)cc([N+](=O)[O-])c1,,CO,,C[O-].[Na+],,val
US20040102465A1,CCOC(=O)CSc1nccc(O)n1.O=C1CCC(=O)N1Br>>CCOC(=O)CSc1nccc(Br)n1,,C1COCCO1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100076014A1,COC(=O)CC(=O)OC.O=Cc1ccc2c(cnn2-c2ccc(F)cc2)c1>>COC(=O)C(=Cc1ccc2c(cnn2-c2ccc(F)cc2)c1)C(=O)OC,CC(=O)O,c1ccccc1,,,,val
US20120238559A1,Cc1ccc(S(=O)(=O)n2ccc3c(-c4cc(N)c5cnn(C)c5c4)ccnc32)cc1.Cc1nc(C(=O)Cl)cs1>>Cc1ccc(S(=O)(=O)n2ccc3c(-c4cc(NC(=O)c5csc(C)n5)c5cnn(C)c5c4)ccnc32)cc1,,ClCCl,,c1ccncc1,,val
US04244961,CC(C)C(=O)O.O=C1CCN(C(=O)OCc2ccccc2)CC1>>CC(C)(C(=O)O)C1(O)CCN(C(=O)OCc2ccccc2)CC1,,C1CCOC1,CCOCC,CC(C)NC(C)C,[Li]CCCC,val
US20110319378A1,C=CC[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N(C(CC)C(=O)ON=C(N)C2CC2)C1=O>>C=CC[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N([C@@H](CC)c2nc(C3CC3)no2)C1=O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150025205A1,CC1(CC2Cc3c(-c4cc(C(C)(C)C)cc(C(C)(C)C)c4)cccc3C2O)CCCCC1>>CC1(CC2=Cc3cccc(-c4cc(C(C)(C)C)cc(C(C)(C)C)c4)c3C2)CCCCC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20100317686A1,Nc1cnoc1.O=C(O)c1cn2cc(I)ccc2n1>>O=C(Nc1cnoc1)c1cn2cc(I)ccc2n1,,c1ccncc1,,CCN=C=NCCCN(C)C,Cl,val
US20130137699A1,CCOC(=O)/C=C/c1cnc(-c2ccc(OCc3ccccc3)c(C34CC5CC(CC(C5)C3)C4)c2)cn1>>CCOC(=O)/C=C/c1cnc(-c2ccc(O)c(C34CC5CC(CC(C5)C3)C4)c2)cn1,,ClCCl,,BrB(Br)Br,,val
US20150031670A1,CCOC(=O)Cl.O=C1CCCCCN1c1ccccc1>>CCOC(=O)C1CCCCN(c2ccccc2)C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US04629737,COC(=O)COc1ccc(CCOS(=O)(=O)c2ccc(C)cc2)cc1.COC(CN)c1cccc(Cl)c1>>COC(=O)COc1ccc(CCNCC(OC)c2cccc(Cl)c2)cc1,,CS(C)=O,,CCN(CC)CC,O=C([O-])[O-].[Na+].[Na+],val
US20070265270A1,COc1ccc(C(O)C(C)N)cc1.O=C(Cl)CCl>>COc1ccc(C(O)C(C)NC(=O)CCl)cc1,O,ClCCl,,[Na+].[OH-],,val
US20160207883A1,CC(C)(C)[Si](C)(C)Oc1ccc(N2CC(OCCOC3CCCCO3)C2)cc1>>Oc1ccc(N2CC(OCCOC3CCCCO3)C2)cc1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20160271270A1,CC(=O)N[C@@H](CCCCNC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)N(C)CCN(C)C(=O)OC(C)(C)C)cc1)C(C)C>>CNCCN(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(=O)OCC2c3ccccc3-c3ccccc32)NC(C)=O)C(C)C)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06288061B1,CN1CCCNCC1.N#Cc1ccc(F)cc1>>CN1CCCN(c2ccc(C#N)cc2)CC1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160122342A1,C=CCNC.COc1nc(C)cc(COS(C)(=O)=O)c1C#N>>C=CCN(C)Cc1cc(C)nc(OC)c1C#N,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US05134123,BrC1CCC1.CC(C)(C)OC(=O)N1[C@@H](CC2CCCCC2)[C@H](C=O)OC1(C)C>>CC(C)(C)OC(=O)N1[C@@H](CC2CCCCC2)[C@H]([C@@H](O)C2CCC2)OC1(C)C,,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US20160090374A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H]1CCCN(c2nc(Cl)nc3c2CCCC3)C1>>CC(C)(C)OC(=O)N[C@@H]1CCCN(c2nc(Cl)nc3c2CCCC3)C1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US06350761B1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(NC(=O)C(F)(F)F)cc2[N+](=O)[O-])CC1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(N)cc2[N+](=O)[O-])CC1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20150045367A1,COC(=O)/C=C/c1ccccc1Oc1ccc(Cl)cc1.NO>>O=C(/C=C/c1ccccc1Oc1ccc(Cl)cc1)NO,,CC(C)O,O,CCOC(C)=O,[Na+].[OH-],val
US20110105761A1,Brc1ccc(-n2ccnc2)cc1.CCCCCCCCCCCCCCBr>>CCCCCCCCCCCCCCn1cc[n+](-c2ccc(Br)cc2)c1.[Br-],,C1CCOC1,,,,val
US04593102,NO.O=C1CCC(Br)CC1.c1ccc(Sc2ccccc2)cc1>>ON=C1CCC(Sc2ccccc2)CC1,,CN(C)C=O,,[Na],,val
US20130102009A1,CC(C)(C)OC(=O)N1CCNCC1.N#Cc1ccc(NC(=O)c2cccc3[nH]c(-c4ccc(Cl)nc4)nc23)cc1C(F)(F)F>>CC(C)(C)OC(=O)N1CCN(c2ccc(-c3nc4c(C(=O)Nc5ccc(C#N)c(C(F)(F)F)c5)cccc4[nH]3)cn2)CC1,,CS(C)=O,O,,,val
US20070004695A1,CNN.COc1cccc(C(=O)c2sccc2Br)c1>>COc1cccc(-c2nn(C)c3ccsc23)c1,,OCCO,,,,val
US20150005282A1,CC(C)(C)OC(=O)N1CC(OS(C)(=O)=O)C1.COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)cc(O)cc4C)c3)ccc21>>COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)cc(OC5CN(C(=O)OC(C)(C)C)C5)cc4C)c3)ccc21,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20080275038A1,CC(C)[Si](c1ncco1)(C(C)C)C(C)C.CCCC[Sn](Cl)(CCCC)CCCC>>CCCC[Sn](CCCC)(CCCC)c1cnc([Si](C(C)C)(C(C)C)C(C)C)o1,,C1CCOC1,CCOC(C)=O,[Li]C(C)(C)C,,val
US20150087585A1,C[C@H]1CCN(C(=O)OC(C)(C)C)C[C@H]1C(=O)N(C)C.Cl>>C[C@H]1CCNC[C@H]1C(=O)N(C)C.Cl,,CCOCC,,,,val
US20080318963A1,CCOC(=O)Nc1nc2cc(OC)c(OC)cc2nc1OC.COc1cccc(N2CCNCC2)c1>>COc1cccc(N2CCN(C(=O)Nc3nc4cc(OC)c(OC)cc4nc3OC)CC2)c1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20150045409A1,CCCCC/C=C/C(=O)Cl.NCC1CCOCC1>>CCCCC/C=C/C(=O)NCC1CCOCC1,,O,,C1CCOC1,CCN(CC)CC,val
US05026855,CC(=O)OC(c1ccc(Cl)cc1)c1cnc(C)c(O)c1CO.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCc2c(C(O)c3ccc(Cl)cc3)cnc(C)c2O)cc1,,ClCCl,,c1ccncc1,,val
US20070010573A1,CC(C)(N)c1ccccc1.O=S1(=O)CCCO1>>CC(C)(NCCCS(=O)(=O)O)c1ccccc1,,C1CCOC1,C1CCOC1,,,val
US20070099986A1,CO.O=C(O)CCCC(=O)c1ccc2c(c1)CCO2>>COC(=O)CCCC(=O)c1ccc2c(c1)CCO2,,CO,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20130165437A1,COc1ccc2c(c1)CCn1c-2cc(Cl)nc1=O.OCC1COCCO1>>COc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O,,ClCCl,,[H-].[Na+],,val
US20140161729A1,CC(C)(C)OC(=O)NCc1cccc(C2CCN(C(=O)c3cccc(/C=C/B(O)O)c3)CC2)c1.Cl>>Cl.NCc1cccc(C2CCN(C(=O)c3cccc(/C=C/B(O)O)c3)CC2)c1,,CO,,,,val
US20130317218A1,NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(F)cc1.NCCO>>NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(NCCO)cc1,,CN1CCCC1=O,O,,,val
US05523277,COC(=O)C(C)Oc1ccc(-n2nnc3cc(F)c(NC(C)=O)cc32)cc1>>COC(=O)C(C)Oc1ccc(-n2nnc3cc(F)c(N)cc32)cc1,O=S(=O)(O)O,CO,,Cl,O,val
US05521177,CCc1nc2c(C)cc(NC(=NC#N)OOc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1.CNC>>CCc1nc2c(C)cc(NC(=NC#N)N(C)C)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,CC(C)O,,,,val
US20100216746A1,CC[Zn]CC.C[Si](C)(C)CCOCn1cnc(Cl)c1C(=O)NCc1ccc(Cl)c(Oc2cc(Cl)cc(Br)c2)c1F>>CCc1cc(Cl)cc(Oc2c(Cl)ccc(CNC(=O)c3c(Cl)ncn3COCC[Si](C)(C)C)c2F)c1,,C1CCOC1,CCOC(C)=O,CC(C)C[AlH]CC(C)C,,val
US03971806,BrBr.O=c1ccsc2c1[nH]c1ccccc12>>O=c1ccsc2c1[nH]c1ccc(Br)cc12,,CC(=O)O,,,,val
US20090153031A1,CC(=O)Nc1ccc2c(c1)Sc1ccc(NC(C)=O)cc1S2>>Nc1ccc2c(c1)Sc1ccc(N)cc1S2,,CCO,,Cl,,val
US05317016,COc1ccc(COC(=O)N2C[C@H](OS(C)(=O)=O)C[C@H]2COS(=O)(=O)c2ccc(C)cc2)cc1.O=C1NC(=O)c2ccccc21>>COc1ccc(COC(=O)N2C[C@H](OS(C)(=O)=O)C[C@H]2CN2C(=O)c3ccccc3C2=O)cc1,,CN(C)C=O,,[K],,val
US20100144715A1,CC(C)(C)OC(=O)N[C@H]1CSc2ccccc2NC1=O.CC(C)I>>CC(C)N1C(=O)[C@@H](NC(=O)OC(C)(C)C)CSc2ccccc21,,CN(C)C=O,O,[H-].[Na+],,val
US20140171408A1,Fc1c(N=C(Cl)c2c(Cl)cc(I)cc2Cl)ccnc1Cl.NC(N)=S>>Clc1cc(I)cc(Cl)c1-c1nc2ccnc(Cl)c2s1,,CC(C)O,,CCN(CC)CC,c1ccncc1,val
US20020103229A1,CC(=O)n1nc(-c2ccc(F)cc2)c2cc(C(=O)Cl)ccc21.[NH4+]>>NC(=O)c1ccc2[nH]nc(-c3ccc(F)cc3)c2c1,,ClCCl,,O,,val
US20120022045A1,CC(C)(C)[Si](C)(C)Cl.O=C1CCC(CO)C1>>CC(C)(C)[Si](C)(C)OCC1CCC(=O)C1,,CN(C)C=O,O,c1c[nH]cn1,,val
US20120202785A1,CC[C@H](NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2n1-c1cncc(F)c1>>CC[C@H](N)c1nc2ccc(F)cc2n1-c1cncc(F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060004052A1,Cn1cc(-c2[nH]c3cc(NC(=O)CCl)cc4c3c2C=NNC4=O)cn1.NCc1ccccc1>>Cn1cc(-c2[nH]c3cc(NC(=O)CNCc4ccccc4)cc4c3c2C=NNC4=O)cn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06395733B1,C#Cc1cccc(N)c1.Clc1ncnc2[nH]cc(Br)c12>>C#Cc1cccc(Nc2ncnc3[nH]cc(Br)c23)c1,,CO,,,,val
US20090098218A1,BrCCOCCBr.Oc1cc(Br)ccc1F>>COCCOc1cc(Br)ccc1F,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20050090493A1,CCN(CC)CC.Cc1ccc(C)c(N)c1.Clc1ccnc(Cl)n1>>CCCC(C)C.Cc1ccc(C)c(Nc2ccnc(Cl)n2)c1,,CCO,,,,val
US20150376233A1,C=CCCCC[C@@H](COC)[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)OC>>C=CCCCC[C@@H](COC)[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)O,,C1CCOC1,O,CO,[Li+].[OH-],val
US20090029965A1,Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1OCCCC1CCN(C(=O)OC(C)(C)C)CC1.Cl>>Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1OCCCC1CCNCC1.Cl,,C1COCCO1,CO,,,val
US20150079035A1,CCOC(=O)c1ccc(NC2CCCCCCC2)c(N)c1.CI.CN(C)C=O>>CCOC(=O)c1ccc(NC2CCCCCCC2)c(N(C)C)c1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20050004119A1,CC(C)(C)[Si](C)(C)OCC=O.NCC1CC1>>CC(C)(C)[Si](C)(C)OCCNCC1CC1,,CO,,[Na+].[OH-],,val
US06329546B1,CCOC(=O)C(C)=Cc1cc(OC)c(OC)cc1N>>COc1cc(N)c(C=C(C)C(=O)O)cc1OC,,C1CCOC1,,Cl,[Na+].[OH-],val
US05665719,CI.COC(=O)c1ccc(OC2CCCN(C(=O)OC(C)(C)C)C2)cc1O>>COC(=O)c1ccc(OC2CCCN(C(=O)OC(C)(C)C)C2)cc1OC,,CN(C)C=O,,[H-].[Na+],,val
US05936000,C#CCC(CC#C)C(=O)O.CC(C)(C)O.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>C#CCC(CC#C)NC(=O)OC(C)(C)C,,Cc1ccccc1,,CCN(CC)CC,,val
US20110098324A1,CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(Cc2ccccc2C(F)(F)F)c1=O.NCC(F)(F)F>>O=C(O)CNC(=O)c1c(O)c(C(=O)NCC(F)(F)F)c(O)n(Cc2ccccc2C(F)(F)F)c1=O,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,Cl,val
US05849764,Cc1cc(C)cc(-c2[nH]c3ccccc3c2C(=O)C(=O)N2CCC(c3ccncc3)CC2)c1>>Cc1cc(C)cc(-c2[nH]c3ccccc3c2CCN2CCC(c3ccncc3)CC2)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100063107A1,CCOC(=O)c1cccc(-n2nc(C(C)(C)C)cc2N)c1.O=C(Cl)Oc1ccccc1>>CCOC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Oc2ccccc2)c1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20130184253A1,CO[C@H]1CCN(C(=O)OC(C)(C)C)CC1(C)C.Cl>>CO[C@H]1CC[NH2+]CC1(C)C.[Cl-],,CCOCC,,C1COCCO1,,val
US20060217376A1,CC(C)(C)OC(=O)N1CCC(Oc2nn(-c3ccccc3F)c3ccccc23)CC1.Cl>>Cl.Fc1ccccc1-n1nc(OC2CCNCC2)c2ccccc21,,C1COCCO1,CCOC(C)=O,,,val
US07335655B2,C=CCn1c(N)c(N)c(=O)n(CC=C)c1=O.CCOC(=O)COc1cc(C(=O)O)n(C)n1>>C=CCn1c(=O)c2[nH]c(-c3cc(OCC(=O)O)nn3C)nc2n(CC=C)c1=O,,CO,,CCN=C=NCCCN(C)C,,val
US20120142689A1,CC(C)(C)OC(=O)N1CC[C@H]([C@@H](CS(=O)(=O)Cl)Oc2ccc(C(F)(F)F)cc2)C1.N.O=C(O)C(F)(F)F>>NS(=O)(=O)C[C@@H](Oc1ccc(C(F)(F)F)cc1)[C@H]1CCNC1.O=C(O)C(F)(F)F,,ClCCl,,C1COCCO1,,val
US04497817,Clc1ccc(-c2cn3c(n2)sc2ccccc23)cc1.II>>Clc1ccc(-c2nc3sc4ccccc4n3c2I)cc1,,ClCCl,,O=C([O-])O.[K+],,val
US20080249093A1,COC(=O)C1Cc2ccc(C#N)c(C)c2C1>>Cc1c(C#N)ccc2c1CC(C(=O)O)C2,,CO,,[Na+].[OH-],,val
US20160016908A1,CC(=O)Cl.CC(=O)N1c2ccc(C#N)cc2[C@H](Nc2cccc(OCCN)n2)[C@@H](C)[C@@H]1C1CC1>>CC(=O)NCCOc1cccc(N[C@H]2c3cc(C#N)ccc3N(C(C)=O)[C@@H](C3CC3)[C@@H]2C)n1,,ClCCl,,c1ccncc1,,val
US04351893,COC(Cl)Cl.c1ccc2c(c1)CCCC2>>O=Cc1ccc2c(c1)CCCC2,Cl[Ti](Cl)(Cl)Cl,,,,,val
US06001839,CC(C)(C)n1cc(-c2ccc(Sc3ccccc3)cc2)c2c(N)ncnc21.O>>CC(C)(C)n1cc(-c2ccc(S(=O)c3ccccc3)cc2)c2c(N)ncnc21,,CC(=O)O,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20120108585A1,COC(=O)c1cccc2sc(Cl)nc12.OB(O)c1cccc(C(F)(F)F)c1>>COC(=O)c1cccc2sc(-c3cccc(C(F)(F)F)c3)nc12,,C1COCCO1,CCO,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20130281359A1,Cn1ncc2c1CN(C(=O)OC(C)(C)C)CC2O.O=C1c2ccccc2C(=O)N1O>>Cn1ncc2c1CN(C(=O)OC(C)(C)C)CC2ON1C(=O)c2ccccc2C1=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140315888A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2.Clc1cnc2nc(Cl)c(Cl)nc2c1>>CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2c1nc2ncc(Cl)cc2nc1Cl,,ClCCl,,,,val
US20130331571A1,CCOC(=O)CBr.COc1ccc(CN2C[C@H](C(C)C)NC2=O)c(OC)c1>>CCOC(=O)CN1C(=O)N(Cc2ccc(OC)cc2OC)C[C@@H]1C(C)C,,CN(C)C=O,,[H-].[Na+],,val
US05336778,CCCCC(=NNC(=O)c1ccco1)OCC.NCc1ccc([N+](=O)[O-])cc1>>CCCCc1nnc(-c2ccco2)n1Cc1ccc([N+](=O)[O-])cc1,,CCO,,Cl,,val
US20150291657A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O.CC1(C)OC(=O)CC(=O)O1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)C1C(=O)OC(C)(C)OC1=O,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05198434,CCc1cc(=O)c2c([nH]1)CCCN2.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCc1cc(=O)c2c([nH]1)CCCN2C(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US04006137,CC1N(C)C=C[NH+]1C.Cn1cccc1C=O.[I-]>>CN1C=C[NH+](C)C1C=Cc1cccn1C.[I-],,CCO,,O,[K+].[OH-],val
US05622976,CC(=O)OC(CCCC1CCN(Cc2ccccc2)CC1)C(N)=NO.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>CC(=O)OC(CCCC1CCN(Cc2ccccc2)CC1)C(N)=NOC(=O)c1ccc([N+](=O)[O-])cc1,,C1CCOC1,,,,val
US20100331295A1,CS(=O)(=O)c1cccc(-c2ccc(-c3cc(C(F)(F)F)nn3-c3ccccc3Br)s2)c1.OB(O)c1cccnc1>>CS(=O)(=O)c1cccc(-c2ccc(-c3cc(C(F)(F)F)nn3-c3ccccc3-c3cccnc3)s2)c1,,CCOC(C)=O,O,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US05372939,O=C(CO)[C@@H](O)[C@H](O)CO.O=C[C@H](O)[C@@H](O)[C@H](O)CO>>O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,,CCO,,,,val
US06136992,C[C@]12CC[C@@H]3c4cc(OCC(F)(F)F)c(O)cc4C(=O)C[C@H]3[C@@H]1CC[C@@H]2O.NO>>C[C@]12CC[C@@H]3c4cc(OCC(F)(F)F)c(O)cc4C(=NO)C[C@H]3[C@@H]1CC[C@@H]2O,,CO,O,Cl,CC(=O)[O-].[Na+],val
US20110034450A1,CC(C)(C)OC(=O)/C=C/c1ccc(F)c([N+](=O)[O-])c1>>CC(C)(C)OC(=O)CCc1ccc(F)c(N)c1,[Pd],C1CCOC1,CCO,,,val
US20030186944A1,COC(=O)c1ccc(Cc2ccccc2NC(=O)OC(C)(C)C)cc1C(=O)OC>>COC(=O)c1ccc(Cc2ccccc2N)cc1C(=O)OC,,CCOCC,CO,Cl,,val
US04879295,CCOC(=O)C(=O)CBr.NC(=S)c1ccco1>>CCOC(=O)c1csc(-c2ccco2)n1,,CCO,,,,val
US20130281433A1,CNN.O=C(c1cncnc1)c1cc(Br)ccc1F>>Cn1nc(-c2cncnc2)c2cc(Br)ccc21,,C1COCCO1,,,,val
US05618811,Cc1ccc2c(c1)C(=O)CCC2C1CCCCC1.NO>>Cc1ccc2c(c1)C(=NO)CCC2C1CCCCC1,,CO,,CCN(CC)CC,Cl,val
US20110053912A1,COC(=O)c1cnc(Cl)nc1C(F)(F)F.NCc1ccc(Cl)cc1Cl>>COC(=O)c1cnc(NCc2ccc(Cl)cc2Cl)nc1C(F)(F)F,,CCOC(C)=O,,C1COCCO1,,val
US20070219181A1,COC(=O)C(CCCCl)c1ccccc1Br.NN>>NN1CCCC(c2ccccc2Br)C1=O,,CCO,,O,,val
US03950437,CC(=O)OO.Cc1ccc(O)cc1>>Cc1ccc(O)c(O)c1,,CC(C)=O,,,,val
US06359134B1,Cc1nc(-c2ccncc2)sc1C(=O)N1CCN(S(=O)(=O)c2cnc3cc(Cl)ccc3c2Cl)CC1>>Cc1nc(-c2ccncc2)sc1C(=O)N1CCN(S(=O)(=O)c2cnc3cc(Cl)ccc3c2)CC1,[Zn],CC(=O)O,,,,val
US20020115674A1,CCOC(=O)c1cc(F)c(N2CCN(C)CC2)nc1NC1CC1>>CN1CCN(c2nc(NC3CC3)c(C(=O)O)cc2F)CC1,,C1CCOC1,O,[Na+].[OH-],,val
US20090042890A1,COC(=O)c1nc(-c2cccc(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)c2)nc(NCC2CCOCC2)c1N.COC(=O)c1nc(-c2cccc(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)c2)nc2c1[nH]c(=O)n2CC1CCOCC1>>NC(=O)c1nc(-c2cccc(O)c2)nc2c1[nH]c(=O)n2CC1CCOCC1,,ClCCl,,,,val
US20090163508A1,Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.Fc1cccc(-c2ccnc(N3CCNCC3)n2)c1>>Cc1noc(NC(=O)N2CCN(c3nccc(-c4cccc(F)c4)n3)CC2)c1C,,C1CCOC1,CCCCCC,Cl,Cl,val
US20070010455A1,O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.O=C1NCc2ccccc21>>O=C(OC1=NCc2ccccc21)Oc1ccc([N+](=O)[O-])cc1,,C1CCOC1,,[H-].[Na+],,val
US20090124612A1,Cc1cc(-c2ccc3nnc(CNC(=O)OC(C)(C)C)n3n2)on1>>Cc1cc(-c2ccc3nnc(CN)n3n2)on1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040138283A1,Brc1ccc2[nH]ccc2c1.OB(O)c1ccc(OC(F)(F)F)cc1>>FC(F)(F)Oc1ccc(-c2ccc3[nH]ccc3c2)cc1,,CCOC(C)=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20160060237A1,CCOC(=O)C=C(C)c1ccc(N(CC(C)C)CC(C)C)c([N+](=O)[O-])c1>>CCOC(=O)CC(C)c1ccc(N(CC(C)C)CC(C)C)c(N)c1,[Pd],CCOC(C)=O,,,,val
US20120029026A1,COC(=O)c1cccc(OCc2nc3ccc(O)cc3n2C)c1.Fc1ccc(Br)c(Cl)n1>>COC(=O)c1cccc(OCc2nc3ccc(Oc4ccc(Br)c(Cl)n4)cc3n2C)c1,I[Cu]I,CN(C)C=O,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US20140005168A1,Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C)c(N3C[C@@H](NC(=O)OC(C)(C)C)CCC3=O)n2)n1>>Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C)c(N3C[C@@H](N)CCC3=O)n2)n1,,Cl,,C1COCCO1,,val
US20050119489A1,CCc1nn(C(=O)OC(C)(C)C)c(CC)c1S(=O)(=O)c1ccc([N+](=O)[O-])cc1>>CCc1nn(C(=O)OC(C)(C)C)c(CC)c1S(=O)(=O)c1ccc(N)cc1,,CCOC(C)=O,,,,val
US20080255189A1,BrCCCCCBr.Oc1cccc2[nH]ccc12>>BrCCCCCOc1cccc2[nH]ccc12,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US05521181,CCOC(=O)c1ccccc1NC.O=C=NCCCl>>Cn1c(=O)n(CCCl)c(=O)c2ccccc21,,Cc1ccccc1,,,,val
US20100099665A1,CC(C)(C)OC(=O)N1CCN(Cc2cn(CC3(CO[Si](C)(C)C(C)(C)C)CCC3)c(=O)c3ccc(Br)cc23)CC1.Cc1c(F)cc(C(=O)NC2CC2)cc1B1OC(C)(C)C(C)(C)O1>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(CC3(CO)CCC3)cc(CN3CCNCC3)c2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090099227A1,COc1cccnc1[N+](=O)[O-].c1cc2oc(-c3nc(CC4CCNCC4)no3)cc2cn1>>COc1cccnc1N1CCC(Cc2noc(-c3cc4cnccc4o3)n2)CC1,,CS(C)=O,,CC(=O)O,,val
US20130210819A1,Clc1ncnc2ccc(I)cc12.c1ccc2c(c1)CCCN2.c1ccc2ncncc2c1>>c1ccc2c(c1)CCCN2c1ncnc2ccc(-c3cnc4[nH]ccc4c3)cc12,,C1COCCO1,,CCN(CC)CC,,val
US20080269192A1,C[C@H]1COCc2nc3c(N)nc4cc(OCc5ccccc5)ccc4c3n21>>C[C@H]1COCc2nc3c(N)nc4cc(O)ccc4c3n21,[Pd],CCO,,ClC(Cl)Cl,,val
US20010027193A1,CS(=O)(=O)CC1=CCN(C(O)=S)CC1.O=C1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1>>O=S(=O)(CC1=CCN(C(O)=S)CC1)CC1(O)CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1,,C1CCOC1,O,CC(C)(C)[O-].[K+],,val
US04843087,O=C(NCCCO)c1ccc(O)cc1>>Oc1ccc(C2=NCCCO2)cc1,,O=S(Cl)Cl,,,,val
US20090036473A1,CC(C)c1nc2ccccc2c(=O)n1N.O=C(O)C1CC1c1ccc(Cl)cc1>>CC(C)c1nc2ccccc2c(=O)n1NC(=O)[C@@H]1C[C@@H]1c1ccc(Cl)cc1,,CN(C)C=O,ClCCl,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20050043334A1,CC(C)(C)OC(=O)N1CC2N=C(Nc3ccc4ncnc(Nc5ccc(OCc6ccccn6)c(Cl)c5)c4c3)OC2C1>>Clc1cc(Nc2ncnc3ccc(NC4=NC5CNCC5O4)cc23)ccc1OCc1ccccn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060166933A1,CC1=C(COCC[Si](C)(C)C)C(c2ccc(OCCN3CCCCC3)cc2)Oc2cc(OCOCC[Si](C)(C)C)ccc21>>CC1=C(COCC[Si](C)(C)C)C(c2ccc(OCCN3CCCCC3)cc2)Oc2cc(O)ccc21,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040058923A1,NCC1CN(CCCc2ccc(Cl)c(Cl)c2)CCO1.O=C(O)Cc1ccccc1>>O=C(Cc1ccccc1)NCC1CN(CCCc2ccc(Cl)c(Cl)c2)CCO1,,CN1CCCC1=O,,,,val
US20140275092A1,O=c1c2ccccc2[nH]c2c(C=NO)cnn12>>N#Cc1cnn2c(=O)c3ccccc3[nH]c12,,ClC(Cl)Cl,,O=P(Cl)(Cl)Cl,,val
US20020115640A1,CCOC(C)=O.CI.CN(C)C=O.Cn1cncc1C(OCc1c[nH]c(=O)cc1-c1cccc(Cl)c1)c1ccc(C#N)cc1>>Cn1cncc1C(OCc1cn(C)c(=O)cc1-c1cccc(Cl)c1)c1ccc(C#N)cc1.[NH4+].[OH-],,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20090209553A1,CC(C)[Si](C(C)C)(C(C)C)n1ncc2cc(N3CCN(Cc4ccccc4)C(=O)C3CC3CCOCC3)ccc21>>c1ccc(CN2CCN(c3ccc4[nH]ncc4c3)C(CC3CCOCC3)C2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20150239845A1,CC(C)(C)Oc1cc(Br)c2cc(C(=O)c3ccc(Cl)cc3)ccc2n1.c1cscn1>>CC(C)(C)Oc1cc(Br)c2cc(C(O)(c3ccc(Cl)cc3)c3nccs3)ccc2n1,,C1CCOC1,,[Li]CCCC,,val
US20090186870A1,CCOc1cc(Cl)c(C(=O)O)cc1NN.CO.Cl>>CCOc1cc(Cl)c(C(=O)OC)cc1NN.Cl,,CO,,CC(=O)Cl,,val
US04276216,CCCCCC(C)=CCCC(=O)CBr.O=C(OO)c1cccc(Cl)c1>>CCCCCC1(C)OC1CCC(=O)CBr,,ClCCl,,,,val
US05744612,CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C#N)cc1.[N-]=[N+]=[N-]>>CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,Cc1ccccc1,,CCN(CC)CC,Cl,val
US20100113514A1,COc1ccccc1OCC1CO1.O=C1CCc2cc(-c3ccc(F)cc3F)ccc2N1>>COc1ccccc1OCC(O)CN1C(=O)CCc2cc(-c3ccc(F)cc3F)ccc21,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150183801A1,Nc1ncc(B(O)O)cn1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(Cl)c1>>Nc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)cn1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US07288537B2,Fc1ccc(OC2CNC2)cc1.O=C=NCCCBr.c1ccc2c(c1)CCCN2>>O=C(NCCCN1CC(Oc2ccc(F)cc2)C1)N1CCCc2ccccc21,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20100261678A1,C1CCOC1.CCN(C(C)C)C(C)C.ClCCl.O=C(O)c1cc(Cl)nc(-c2ccccc2)n1>>CO[C@H]1CCN(c2cc(C(=O)O)nc(-c3ccccc3)n2)C1,,C1CCOC1,,O,,val
US20100234377A1,CC(C)C(=N)NO.COC(=O)c1cccc(NC(=O)N2CCN(C(=O)c3cccc(F)c3)CC2)c1>>CC(C)c1noc(-c2cccc(NC(=O)N3CCN(C(=O)c4cccc(F)c4)CC3)c2)n1,,C1CCOC1,,[H-].[Na+],,val
US20150231152A1,CCN(CC)CC.CN(C)C=O.CNOC.CO.On1nnc2ccccc21>>CON(C)C(=O)c1cccc(OC2CC2)c1N,,CO,O,Cl,O=C(O)C(F)(F)F,val
US05958924,COC(=O)CC1=CCN(C)c2ccc(Cl)cc21>>Cn1c(=O)cc(CCO)c2cc(Cl)ccc21,,C1CCOC1,,CO,[BH4-].[Na+],val
US04656265,CN1C(C(=O)Nc2ccccn2)=C(O)c2sccc2S1(=O)=O.O=C(Cl)Cl>>CN1c2c(oc(=O)n(-c3ccccn3)c2=O)-c2sccc2S1(=O)=O.Cl,,Cc1ccccc1,,CCN(CC)CC,,val
US20130197049A1,CON.COc1cc(C(=O)c2csc(-c3ccccc3)n2)cc(OC)c1OC>>CO/N=C(/c1cc(OC)c(OC)c(OC)c1)c1csc(-c2ccccc2)n1,,c1ccncc1,,Cl,,val
US20050107616A1,CC(C)(C)[C@H](O)CCc1nnc(-c2ccc(C(F)(F)F)cc2)o1.CCCC[C@H](N=C=O)C(=O)OC.N#CC=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCC[C@H](NC(=O)O[C@H](CCc1nnc(-c2ccc(C(F)(F)F)cc2)o1)C(C)(C)C)C(=O)C(C#N)=P(c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)c1ccncc1,Cc1ccccc1,O,[Li+].[OH-],,val
US20060089359A1,CC(C)n1nc(Br)c2ccc(N)cc2c1=O.CN=C=O>>CNC(=O)Nc1ccc2c(Br)nn(C(C)C)c(=O)c2c1,,C1CCOC1,,[H-].[Na+],,val
US20050137243A1,COC(CCn1ncc2ccc(NC(=O)Cc3ccc(Oc4ccccc4)cc3)cc21)OC>>O=CCCn1ncc2ccc(NC(=O)Cc3ccc(Oc4ccccc4)cc3)cc21,,CC(C)=O,,Cl,,val
US20100105653A1,CC(C)(C)OC(=O)N1CCCN(c2ccc([N+](=O)[O-])nc2)CC1>>CC(C)(C)OC(=O)N1CCCN(c2ccc(N)nc2)CC1,[Pd],,,[H][H],,val
US20120329649A1,C=Cc1ccc2[nH]ccc2c1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=Cc1ccc2c(ccn2C(=O)OC(C)(C)C)c1,CN(C)c1ccncc1,CC#N,ClCCl,,,val
US05496872,COC(=O)[C@@H](N)CSSC[C@H](N)C(=O)OC>>COC(=O)[C@@H](N)CSSC[C@H](N)C(=O)OC,,O,,CCN=C=NCCCN(C)C,Cl,val
US20120245144A1,CC(C)n1ncnc1-c1cn2c(n1)-c1cc(CC(=O)OC(C)(C)C)ccc1OCC2>>CC(C)n1ncnc1-c1cn2c(n1)-c1cc(CC(=O)O)ccc1OCC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20010020034A1,CCCCCSc1nsc(NC(=O)Oc2ccccc2)c1C(N)=O.NCCCN1CCCC1>>CCCCCSc1nsc(NC(=O)NCCCN2CCCC2)c1C(N)=O,,C1CCOC1,,[Na+].[OH-],,val
US04126689,CC(C)N1CCC(N(C(=O)Cc2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1.Cl>>CC(C)N1CCC(N(C(=O)Cc2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1.Cl,,CC(C)=O,CCOCC,CC(C)O,,val
US20120270838A1,CC(C)(C)OC(=O)N1CCC2(CC1)NC(=S)NC2=O.CI>>CSC1=NC2(CCN(C(=O)OC(C)(C)C)CC2)C(=O)N1,,CO,,O,[Na+].[OH-],val
US04738710,CCOC(=O)C(C)Oc1ccc(Oc2cnc3cc(Cl)ccc3c2)cc1.CI>>CCOC(=O)C(C)Oc1ccc(Oc2cc3ccc(Cl)cc3[n+](C)c2)cc1.[I-],,ClCCl,,,,val
US20100113412A1,COC(=O)c1ccc(N)nc1.O=C(CBr)c1ccc(F)cc1>>COC(=O)c1ccc2nc(-c3ccc(F)cc3)cn2c1,,C1COCCO1,,,,val
US20070225288A1,CCOC(=O)C1=C(c2ccccc2)c2ccc(OCCCc3ccccc3)cc2C1(O)c1ccccc1>>O=C(O)C1=C(c2ccccc2)c2ccc(OCCCc3ccccc3)cc2C1(O)c1ccccc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US03931204,CC(C)Nc1nc(Cl)nc2cscc12>>CC(C)Nc1ncnc2cscc12,[Zn],CC(=O)O,,CCO,,val
US20080105851A1,CC(C)(C)C(=O)Cl.c1ccc(Nc2ccccn2)nc1>>CC(C)(C)C(=O)N(c1ccccn1)c1ccccn1,,O,,CC#N,CCN(CC)CC,val
US06809208B2,CC(C)(C)c1cc(C(c2ccc(C#N)cc2)N2CCCCC2)c(O)c(C(C)(C)C)c1.O=CO>>CC(C)(C)c1cc2c(c(C(C)(C)C)c1)OC(=O)C2c1ccc(C#N)cc1,,Cc1ccccc1,,,,val
US20100093999A1,Fc1ccccc1[C@]12COCC[C@H]1CON2>>N[C@@]1(c2ccccc2F)COCC[C@H]1CO,[Zn],CC(=O)O,,,,val
US07553969B1,CC(C)C(NCC(Cc1ccc(F)cc1)NC(=O)OC(C)(C)C)C(=O)NC(Cc1ccc(O)c(C(C)(C)C)c1)c1nccs1>>CC(C)C(NCC(N)Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(O)c(C(C)(C)C)c1)c1nccs1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20090163491A1,CC(C)(C)C(=O)Cl.CCCn1c(=O)n(C2CC2)c(=O)c2[nH]c(-c3ccc(NCc4ccc(C(F)(F)F)nc4)nc3)nc21>>CCCn1c(=O)n(C2CC2)c(=O)c2[nH]c(-c3ccc(N(Cc4ccc(C(F)(F)F)nc4)C(=O)C(C)(C)C)nc3)nc21,,c1ccncc1,,,,val
US09303015B2,Nc1ccc(Br)cc1C(=O)C(F)(F)F.O=C(Cl)COc1ccc(Cl)cc1>>O=c1[nH]c2ccc(Br)cc2c(C(F)(F)F)c1Oc1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20040242645A1,COC(=O)c1cccc(C)c1[N+](=O)[O-].N>>Cc1cccc(C(N)=O)c1[N+](=O)[O-],,CO,,,,val
US05849758,COC(=O)C(C)C=O.N=C(N)c1ccc(F)cc1>>Cc1cnc(-c2ccc(F)cc2)[nH]c1=O,,CCO,,Cl,[H-].[Na+],val
US20070032473A1,CC(C)(C)OC(=O)N1CCc2nc(N3C[C@H](NC(=O)c4ccc(Br)s4)CC3=O)sc2CC1>>O=C(N[C@@H]1CC(=O)N(c2nc3c(s2)CCNCC3)C1)c1ccc(Br)s1,,ClCCl,O=C(O)C(F)(F)F,BrBr,,val
US20120238599A1,CN=C=Nc1ccc(I)cc1F.COC(=O)Cc1sccc1C(=O)OC>>COC(=O)c1c(Nc2ccc(I)cc2F)n(C)c(=O)c2ccsc12,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20100152168A1,CC(C)(C)OC(=O)N1CCC(N2CCN(C(=O)OCc3ccccc3)CC2)CC1>>CC(C)(C)OC(=O)N1CCC(N2CCNCC2)CC1,[Pd],CO,,O=CO,,val
US05792764,CSC1=Nc2ccncc2S(=O)(=O)N1C.NCc1ccccc1>>CN1C(NCc2ccccc2)=Nc2ccncc2S1(=O)=O,,C1COCCO1,,CCOCC,,val
US06350749B1,CC(=O)CBr.Cc1ccc(S(=O)(=O)NNC2=CC(=O)CC(c3cc(C)ccc3Cl)C2)cc1>>Cc1ccc(Cl)c(C2CCc3c(C)cnnc3C2)c1,,COCCOC,,CO,O=C([O-])[O-].[K+].[K+],val
US20030139599A1,C=CC(=O)OCC.CCO.CN(C)CCO.c1ccc2c(c1)Nc1ccccc1S2>>C=CC(=O)OCC.C=CC(=O)OCCN(C)C,,CCO,,,,val
US07176310B1,O=C(O)COc1ncc(C(=O)Nc2ccc(F)cc2)cn1.OCC1CC1>>O=C(COc1ncc(C(=O)Nc2ccc(F)cc2)cn1)OCC1CC1,,ClCCl,,CO,,val
US20040214832A1,CCOC(=O)CNCc1ccccc1.COc1ccc(COC[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc1>>CCOC(=O)CN(Cc1ccccc1)C(=O)[C@H](COCc1ccc(OC)cc1)NC(=O)OC(C)(C)C,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140243303A1,CC(Oc1cc(-c2cnn(C3CC4(C3)CN(C(=O)OC(C)(C)C)C4)c2)cnc1N)c1c(Cl)ccc(F)c1Cl.O=CO>>CC(Oc1cc(-c2cnn(C3CC4(CNC4)C3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl.O=CO,,O=CO,,Cc1ccccc1,,val
US20090170791A1,CCOC(=O)c1c[nH]c2c(F)cc(I)cc2c1=O.OCCI>>CCOC(=O)c1cn(CCO)c2c(F)cc(I)cc2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05530019,BrC(Br)(Br)Br.CCCCC(O)c1ccc(CC(C)C)cc1>>CCCCC(Br)c1ccc(CC(C)C)cc1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060258571A1,CC(C)(C)OC(=O)N[C@@H](Cc1cc(I)ccc1OCc1ccccc1)C(=O)O.Cl>>Cl.N[C@@H](Cc1cc(I)ccc1OCc1ccccc1)C(=O)O,,C1COCCO1,,,,val
US06265575B1,COc1ccc(Oc2c(-c3ccc(OC)cc3)sc3ccccc23)cc1>>Oc1ccc(Oc2c(-c3ccc(O)cc3)sc3ccccc23)cc1,,CCOC(C)=O,,,,val
US20120316161A1,COC(=O)C(Cc1ccccc1)c1c(C)nc2cc(C(C)(C)C)nn2c1Cl.Cc1ccc(B(O)O)cc1>>COC(=O)C(Cc1ccccc1)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc(C)cc1,,COCCOC,O,CCN(C(C)C)C(C)C,,val
US03960892,O=C1CSC(=S)N1.O=Cc1ccccc1C(=O)O>>O=C1NC(=S)SC1=Cc1ccccc1C(=O)O,,O,,CC(=O)O,CC(=O)[O-].[Na+],val
US20090062277A1,COc1cc2nncc(Br)c2cc1OC.Cc1cc(B(O)O)cnc1F>>COc1cc2nncc(-c3cnc(F)c(C)c3)c2cc1OC,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20110251196A1,BrC(Br)(Br)Br.CCCC(C)COc1ccc([C@H](CO)NC(=O)OC(C)(C)C)cc1>>CCCC(C)COc1ccc([C@H](CBr)NC(=O)OC(C)(C)C)cc1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130158025A1,Cc1nn2c(-c3ccc(F)c(F)c3)cc(Cl)nc2c1I.OC[C@@H]1CCCN1>>Cc1nn2c(-c3ccc(F)c(F)c3)cc(N3CCC[C@H]3CO)nc2c1I,,CC#N,,CCN(C(C)C)C(C)C,,val
US20160137584A1,CCOC(=O)C(C)(C)CCCCOCc1ccccc1>>CC(C)(CCCCOCc1ccccc1)C(=O)O,,CCO,,O,[K+].[OH-],val
US20140296246A1,CCC(CC)[Mg]Br.CCOc1nc2c(C(=O)c3ccccn3)cc(-c3c(C)noc3C)cc2[nH]1>>CCOc1nc2c(C(O)(c3ccccn3)C(CC)CC)cc(-c3c(C)noc3C)cc2[nH]1,,C1CCOC1,,,,val
US20120115850A1,CS(=O)(=O)c1ccc(F)cc1F.NC1CCOc2ccccc21>>CS(=O)(=O)c1ccc(F)cc1NC1CCOc2ccccc21,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20030158188A1,Cc1nccc2c(N)cccc12.O=C=NCc1ccc(Br)cc1>>Cc1nccc2c(NC(=O)NCc3ccc(Br)cc3)cccc12,,Cc1ccccc1,,,,val
US20120269738A1,Cc1ccnc2ccccc12.OCCCBr>>Cc1cc[n+](CCCO)c2ccccc12.[Br-],,CC#N,,,,val
US06277871B1,CC(C)(C)OC(=O)N1CCCC1CO.Oc1ccccc1>>CC(C)(C)OC(=O)N1CCC[C@H]1COc1ccccc1,,Cc1ccccc1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150315229A1,CCCCCCCCCCCCCCCCCCCCOc1cccc(C(=O)O)c1OCCCCCCCCCCCCCCCCCCCC.O=S(Cl)Cl>>CCCCCCCCCCCCCCCCCCCCOc1cccc(C(=O)Cl)c1OCCCCCCCCCCCCCCCCCCCC,,CN(C)C=O,,Cc1ccccc1,,val
US20130053409A1,C=CC(=O)Cl.COc1cc(N2CC[C@@H](N(C)C)C2)c(N)cc1Nc1nccc(-c2cnn3c2CCCC3)n1>>C=CC(=O)Nc1cc(Nc2nccc(-c3cnn4c3CCCC4)n2)c(OC)cc1N1CC[C@@H](N(C)C)C1,,ClCCl,,CC#N,,val
US20160222060A1,COC(=O)[C@H](C)n1nnnc1[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1>>C[C@@H](C(=O)O)n1nnnc1[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1,,CO,,C1CCOC1,[Li+].[OH-],val
US05359076,CCOC(=O)Cc1ccc2c(c1)CCC(c1ccccc1)N2.CI>>CN1c2ccc(CC(=O)O)cc2CCC1c1ccccc1,,CC(C)=O,O,Cl,[K+].[OH-],val
US20040044203A1,NC(=O)Cl.NC1CCNCC1>>NC(=O)C1CCN(N)CC1,,CO,,CCN(C(C)C)C(C)C,,val
US20010027196A1,CC(C)Br.N#Cc1c(-c2ccccc2)nc(N)[nH]c1=S>>CC(C)Sc1nc(N)nc(-c2ccccc2)c1C#N,,CCO,,C,C[O-].[Na+],val
US20140323463A1,CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.OCn1nnc2ccccc21>>CN[C@@H]1CCCC[C@@H]1NC(=O)OC(C)(C)C,,CCOC(C)=O,,CCO,[BH4-].[Na+],val
US20070037807A1,CC(C)(C)O.CC(C)C(=O)Cl.CC1(C)OC(=O)CC(=O)O1>>CC(C)C(=O)CC(=O)OC(C)(C)C,,Cc1ccccc1,ClCCl,Cl,c1ccncc1,val
US20120302566A1,Cc1cccc(C)c1B(O)O.O[C@H]1CCc2c(Br)cccc21>>Cc1cccc(C)c1-c1cccc2c1CC[C@@H]2O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US05086070,COc1ccccc1Br.Cn1ccc2c(C=O)cccc21>>COc1ccccc1C(O)c1cccc2c1ccn2C,,C1CCOC1,,[Mg],,val
US20140256702A1,C[C@@](CO)(C[C@H](N)Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)O.O=CO>>C[C@@](CO)(C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC=O)C(=O)O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050208582A1,CC(C)(C)O.O=C(O)c1cc2c(I)nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c2cn1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)Nc1cc2c(I)nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c2cn1,,CCOC(C)=O,,CCN(CC)CC,,val
US20040110742A1,CS(=O)(=O)Cl.O[C@H]1CCN(CCc2cccc(N3CCCC3)c2)C1>>CS(=O)(=O)O[C@H]1CCN(CCc2cccc(N3CCCC3)c2)C1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20110034526A1,CCS(=O)(=O)c1cccc(F)c1.Cc1nc2c(C(F)(F)F)cccc2n1-c1cccc(O)c1>>CCS(=O)(=O)c1cccc(Oc2cccc(-n3c(C)nc4c(C(F)(F)F)cccc43)c2)c1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20040167155A1,CCC1Nc2ccccc2-c2ccccc21.COc1ccc(S(=O)(=O)Cl)cc1>>CCC1c2ccccc2-c2ccccc2N1S(=O)(=O)c1ccc(OC)cc1,,c1ccncc1,,,,val
US20030191118A1,COC(=O)[C@H](Cc1ccc(-c2ccccc2OC)cc1)NC(=O)c1ccc([N+](=O)[O-])cc1Cl>>COC(=O)[C@H](Cc1ccc(-c2ccccc2OC)cc1)NC(=O)c1ccc(N)cc1Cl,[Ni],CO,,,,val
US20120134934A1,C=COC(=O)NC(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1.O=C(CBr)c1ccccc1>>C=COC(=O)NC(C(=O)O[C@H]1C[N+]2(CC(=O)c3ccccc3)CCC1CC2)c1ccccc1.[Br-],,CC#N,CCOC(C)=O,,,val
US20110065682A1,COC(=O)c1c(OCc2ccc(OC)cc2)c(-c2ccc(N3CCCCC3=O)cc2)nn1C>>COc1ccc(COc2c(-c3ccc(N4CCCCC4=O)cc3)nn(C)c2C(=O)O)cc1,,CO,,O,[Li+].[OH-],val
US20080293706A1,CC(C)(C)OC(=O)N1CCN(c2cnc3ccc(-c4cncc(NS(=O)(=O)c5ccccc5)c4)cc3n2)CC1>>O=S(=O)(Nc1cncc(-c2ccc3ncc(N4CCNCC4)nc3c2)c1)c1ccccc1,,CC#N,,O=C(O)C(F)(F)F,,val
US05661159,COC(=O)c1ccc(OCc2ccc3ccc(Cl)cc3n2)c(C(=O)OC)c1>>COC(=O)c1ccc2oc(-c3ccc4ccc(Cl)cc4n3)c(O)c2c1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20100290992A1,C#CC.Nc1nc(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1I>>CC#Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)nc1N,[Cu]I,CN(C)C=O,,CCN(CC)CC,,val
US20050228062A1,O=C(OCCOCCO)C(=O)c1ccccc1.O=C=Nc1ccc(Cc2ccc(N=C=O)cc2)cc1>>O=C=Nc1ccc(Cc2ccc(NC(=O)OCCOCCOC(=O)C(=O)c3ccccc3)cc2)cc1,,Cc1ccccc1,,,,val
US20120010182A1,CC(C)(C)OC(=O)N1CCN(c2cc(-c3cc(-c4ccc(C(F)(F)F)cc4)ccc3O)ccn2)CC1.COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(F)cc2F)c(OC)c1>>COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3ccc(-c4ccc(C(F)(F)F)cc4)cc3-c3ccnc(N4CCN(C(=O)OC(C)(C)C)CC4)c3)cc2F)c(OC)c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060074071A1,CC(C)(C)OC(=O)N1[C@H](CNCc2cc3ccccc3s2)C[C@@H]2CCCC[C@@H]21.COc1cc(C(=O)Cl)cc2c1OC(C)(C)O2>>COc1cc(C(=O)N(Cc2cc3ccccc3s2)C[C@@H]2C[C@@H]3CCCC[C@@H]3N2)cc2c1OC(C)(C)O2,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20130072519A1,CCOC(=O)C1(C(=O)OCC)CCCc2cccnc21>>CCOC(=O)C1CCCc2cccnc21,,CCO,,[Na+].[OH-],,val
US20090036436A1,CC(C)(C)OC(=O)NC(C(=O)N1CCCC1)C(=NO)c1ccncc1>>NC(C(=O)N1CCCC1)C(=NO)c1ccncc1,,CO,,Cl,,val
US05597826,Nc1ccc2cccc(N3CCN(CO)CC3)c2c1.O=C(Cl)c1cccc([N+](=O)[O-])c1>>CN1CCN(c2cccc3ccc(NC(=O)c4cccc([N+](=O)[O-])c4)cc23)CC1,,CC#N,,CCN(CC)CC,,val
US20090239854A1,BrCCc1ccccn1.CN1CCc2[nH]c3ccc(Cl)cc3c2C1>>CN1CCc2c(c3cc(Cl)ccc3n2CCn2cccc2)C1,,CN1CCCC1=O,O,[K+].[OH-],,val
US20080234199A1,CCCCC(=O)c1ccc(O)cc1.CCOC(=O)CCCBr>>CCCCC(=O)c1ccc(OCCCC(=O)OCC)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090082434A1,COc1ccc(B(O)O)c(OC)c1.Cc1ccc(S(=O)(=O)OCC2Cc3cccc(Br)c3O2)cc1>>COc1ccc(-c2cccc3c2OC(COS(=O)(=O)c2ccc(C)cc2)C3)c(OC)c1,Cc1ccccc1[P](c1ccccc1C)(c1ccccc1C)[Pd](Cl)(Cl)[P](c1ccccc1C)(c1ccccc1C)c1ccccc1C,,,O=C([O-])[O-].[K+].[K+],,val
US20160009703A1,ClCCCBr.On1nnc2ccc(F)cc21>>Fc1ccc2nnn(OCCCCl)c2c1,,CN1CCCC1=O,,O,[H-].[Na+],val
US20160024079A1,CCc1cc(C)c2c(ccn2S(=O)(=O)c2ccc(C)cc2)c1C=O>>CCc1cc(C)c2[nH]ccc2c1C=O,,CCO,ClCCl,[K+].[OH-],,val
US20150223461A1,NO.O=Cc1cncc(Cl)c1>>ON=Cc1cncc(Cl)c1,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20100298295A1,Cc1cc(C)nc(N)c1.Clc1ncc(Cl)c(Cl)n1>>Cc1cc(C)nc(Nc2nc(Cl)ncc2Cl)c1,,CC(=O)N(C)C,,[I-].[K+],,val
US20040023999A1,BrCC1CCCCC1.COc1ccc(F)cc1C(C)(C)CC(=O)N1CCOCC1>>COc1ccc(F)cc1C(C)(C)CC(=O)CC1CCCCC1,,C1CCOC1,,[Li]C(C)(C)C,,val
US05086074,CCOC=O.COc1cccc2c1CCCC2CN>>COc1cccc2c1CCCC2CNC=O,,Cc1ccccc1,,Cl,,val
US04393059,CCCCCCON=C(C(=O)OCC)c1csc(N)n1>>CCCCCCON=C(C(=O)O)c1csc(N)n1,,C1CCOC1,,CO,[Na+].[OH-],val
US05196610,CCOc1ccc(C(O)(C(F)(F)F)C(F)(F)Cl)cc1.O=S(Cl)Cl>>CCOc1ccc(C(Cl)(C(F)(F)F)C(F)(F)Cl)cc1,,Cc1ccccc1,,c1ccncc1,,val
US20070093501A1,CSCC[C@@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)N1CCC(N2Cc3cnc(C)n3C2=O)CC1.O=C(OO)c1cccc(Cl)c1>>Cc1ncc2n1C(=O)N(C1CCN(C(=O)[C@@H](CCS(C)=O)NC(=O)Nc3ccc(Cl)cc3)CC1)C2,,ClCCl,,,,val
US04260410,CC(=NO)C(C)N(C(=O)CCl)c1c(C)cccc1C.O=C=Nc1ccccc1>>CC(=NOC(=O)Nc1ccccc1)C(C)N(C(=O)CCl)c1c(C)cccc1C,CCN(CC)CC,ClCCl,,,,val
US08778983B2,Brc1cccc(-c2ccccc2)n1.CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4N)cc3)cc2)CC1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4Nc4cccc(-c5ccccc5)n4)cc3)cc2)CC1,,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1,O=C([O-])[O-].[Cs+].[Cs+],val
US20040097563A1,CC(C)(C)[Si](C)(C)Oc1ccccc1-c1cc(-c2cccc(NC(=O)C3CCC(=O)O3)c2)c(C#N)c(N)n1>>N#Cc1c(-c2cccc(NC(=O)C3CCC(=O)O3)c2)cc(-c2ccccc2O)nc1N,,C1CCOC1,,,,val
US06884821B1,CCOC(=O)c1cn(C)c(-c2ccccc2)n1>>Cn1cc(C(=O)O)nc1-c1ccccc1,,CCO,,Cl,[Na+].[OH-],val
US20050119271A1,COC(=O)C(=O)Nc1cc(NCCNC(C)=O)nc(-c2ccccc2)n1.c1ccc(N2CCNCC2)cc1>>CC(=O)NCCNc1cc(NC(=O)C(=O)N2CCN(c3ccccc3)CC2)nc(-c2ccccc2)n1,,CS(C)=O,,ClCCl,,val
US20100081825A1,COc1cccc(C(=O)NC2CCN(Cc3ccc4ccc(CCCC5OCCO5)cc4c3)CC2)c1>>COc1cccc(C(=O)NC2CCN(Cc3ccc4ccc(CCCC=O)cc4c3)CC2)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20100120741A1,N#Cc1ccc(Cl)cc1N.O=C1CCC(=O)N1Cl>>N#Cc1cc(Cl)c(Cl)cc1N,,CCOC(C)=O,,CN(C)C=O,,val
US20060069156A1,CCCCCCCCCCCCCCCC(=S)SC(CNC(=O)OC(C)(C)C)CNC(=O)OC(C)(C)C>>CCCCCCCCCCCCCCCC(=S)SC(CN)CN,,CCOCC,Cl,,,val
US04036864,CC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)C(F)(F)F)CC[C@]4(C)[C@H]3CC[C@]12C,,c1ccncc1,,,,val
US20160194328A1,BrCCCBr.Nc1nc(F)nc2[nH]c(Sc3cc(Cl)cc(Cl)c3)nc12>>Nc1nc(F)nc2c1nc(Sc1cc(Cl)cc(Cl)c1)n2CCCBr,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140005164A1,CNCCOC.COC(=O)C1CCC(CN)CC1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>COCCN(C)c1ncc([N+](=O)[O-])c(NC[C@@H]2CC[C@@H](C(=O)OC)CC2)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US04743601,Cc1nc2ccccc2c(NCC(C)O)c1Br>>Cc1nc2ccccc2c2c1OC(C)CN2,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20160222028A1,NCc1ccccc1.O=C1CC(C(=O)O)Oc2cc(O)ccc21>>O=C1CC(C(=O)NCc2ccccc2)Oc2cc(O)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050148609A1,Cc1ccc(C(=O)c2ccc(N)c(C(=O)c3cccc(Cl)c3)c2)cc1.O=C(Cl)C(Cl)(Cl)Cl>>Cc1ccc(C(=O)c2ccc(NC(=O)C(Cl)(Cl)Cl)c(C(=O)c3cccc(Cl)c3)c2)cc1,,ClCCl,,CCN(CC)CC,,val
US20130344023A1,CC(C)(C)OC(=O)NCCS.CC(C)Cc1ccc(C(C)C(=O)O)cc1>>CC(C)Cc1ccc(C(C)C(=O)SCCNC(=O)OC(C)(C)C)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2nc(C(F)(F)F)nn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2nc(C(F)(F)F)nn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20100120841A1,CCOC(=O)CP(=O)(OCC)OCC.O=C1CCCc2c(F)cccc21>>CCOC(=O)C=C1CCCc2c(F)cccc21,,Cc1ccccc1,,[H-].[Na+],,val
US20090209524A1,CCCC[C@@H](CO)Nc1nc(N)nc(C)c1Cc1ccc(CC(=O)O)cc1OC.CO>>CCCC[C@@H](CO)Nc1nc(N)nc(C)c1Cc1ccc(CC(=O)OC)cc1OC,,CO,,Cl,O=C([O-])O.[Na+],val
US20140194386A1,N#CBr.NCc1ccc(C(=O)N[C@@H](Cc2cccc(C(=O)O)c2O)B(O)O)cc1CN>>NC1=NCc2ccc(C(=O)N[C@H]3Cc4cccc(C(=O)O)c4OB3O)cc2CN1,,CN(C)C=O,,,,val
US20100029621A1,Nc1cccc(C(=O)N2CCN(Cc3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)c1.O=C(Nc1ccncc1)Oc1ccccc1>>O=C(Nc1ccncc1)Nc1cccc(C(=O)N2CCN(Cc3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)c1,,C1COCCO1,,,,val
US06207693B1,COc1cc(C(=O)N(C)c2ccc(C)cc2O)ccc1NC(=O)c1cccc([N+](=O)[O-])c1N.O=C1c2ccccc2C(=O)N1CCCCBr>>COc1cc(C(=O)N(C)c2ccc(C)cc2OCCCCN2C(=O)c3ccccc3C2=O)ccc1NC(=O)c1cccc([N+](=O)[O-])c1N,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20130059834A1,C[C@@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3n[nH]c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1>>C[C@@H](NC(=O)c1c[nH]c2ncc(-c3n[nH]c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US05166188,CN(C)C=O.COc1ccc(CCN)cc1Cl.O=C1c2ccccc2C(=O)N1CCCCBr>>COc1ccc(CCN(C)CCCCN)cc1Cl,,O,,O=C([O-])[O-].[K+].[K+],,val
US04092321,CO.O=S(c1ccccc1)c1ccc(Br)nc1>>COc1ccc(S(=O)c2ccccc2)cn1,,CO,,C[O-].[Na+],,val
US20030040533A1,O=Cc1ccc(OCCCl)cc1.O=c1[nH]c2ccccc2o1>>O=Cc1ccc(OCCn2c(=O)oc3ccccc32)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06001331,CCCCCCC[n+]1c(C)sc2ccccc21.CN(C)c1ccc(C=O)c2ccccc12.[I-]>>CCCCCCC[n+]1c(/C=C/c2ccc(N(C)C)c3ccccc23)sc2ccccc21.[I-],,CC(=O)OC(C)=O,,,,val
US20090181942A1,CCOC(=O)C[C@H]1O[C@H](c2cccc(OC)c2OC)c2cc(Cl)ccc2NC1=NN.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)C[C@H]1O[C@H](c2cccc(OC)c2OC)c2cc(Cl)ccc2-n2c1nnc2C(F)(F)F,,ClCCl,,O=C(O)C(F)(F)F,,val
US06936306B1,C1CC[AlH]OC1.COCC(=O)O>>C1CC[AlH]OC1.COCC(=O)[O-],,O,,,,val
US20050101763A1,CC(CO)c1ccccc1[N+](=O)[O-].O=C(Cl)Cl>>CC(COC(=O)Cl)c1ccccc1[N+](=O)[O-],,C1CCOC1,,,,val
US20040209901A1,COCCNC(=O)CNc1nc(-c2ccc(F)cc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1>>Cc1cc(F)ccc1-c1nc(NCC(=O)NCCO)nc2c1ccc(=O)n2-c1c(F)cccc1F,,ClCCl,,BrB(Br)Br,O,val
US05593993,NCCc1c(F)cccc1F.S=C(n1ccnc1)n1ccnc1>>Fc1cccc(F)c1CCNC(=S)n1ccnc1,,CC#N,,,,val
US20140296229A1,Br[Mg]c1ccccc1CN1CCOCC1.Cc1noc(C)c1-c1ccc2c(c1)C(=O)C(=O)N2>>Cc1noc(C)c1-c1ccc2c(c1)C(O)(c1ccccc1CN1CCOCC1)C(=O)N2,,C1CCOC1,,[Cl-].[NH4+],,val
US20020004501A1,C=CCCCBr.O=C1CCCCCCN1>>C=CCCCN1CCCCCCC1=O,,CN(C)C=O,,[H-].[Na+],,val
US20080318878A1,O=C1c2ccccc2C(=O)N1CCCOc1cccc(-c2cccnc2)c1>>NCCCOc1ccc(-c2cccnc2)cc1,,CCO,,NN,O,val
US20120258953A1,CC1(C)OB(c2ccc(-c3ncc[nH]3)cc2)OC1(C)C.O=C(N1CCC(C(F)F)CC1)N1CCOc2ccc(Br)cc2C1>>O=C(N1CCC(C(F)F)CC1)N1CCOc2ccc(-c3ccc(-c4ncc[nH]4)cc3)cc2C1,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100056506A1,Clc1nc(Cl)c2cccc(OC3CCOCC3)c2n1>>Clc1ncc2cccc(OC3CCOCC3)c2n1,[Pd],CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US20050131068A1,CC(=O)O.NCc1ccc(OC(F)(F)F)cc1>>CC(=O)NCc1ccc(OC(F)(F)F)cc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20150018422A1,CCOC(=O)CC(c1cc(COc2cnc(-c3cc(OC)ccc3F)c(CC(C)(C)C)c2)ncn1)C1CC1>>COc1ccc(F)c(-c2ncc(OCc3cc(C(CC(=O)O)C4CC4)ncn3)cc2CC(C)(C)C)c1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20020032340A1,CC[Si](CC)(CC)OC(C)(C)C#CCO[C@@H](C)C1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C>>C[C@H](OCC#CC(C)(C)O)C1=CC[C@H]2C3=CC=C4C[C@@H](O)C[C@H](O)[C@]4(C)[C@H]3CC[C@]12C,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080108624A1,CC(C)(C)OC(=O)N1CCC(CC2CCNCC2)CC1.CC(C)I>>CC(C)N1CCC(CC2CCN(C(=O)OC(C)(C)C)CC2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04355037,Br.COc1ccc2c(C3CCN(C(=O)OCc4ccccc4)CC3)noc2c1>>Br.COc1ccc2c(C3CCNCC3)noc2c1,,CC(=O)O,,,,val
US20060264435A1,Nc1ccc(Br)c(Cl)c1.OB(O)c1cc(C(F)(F)F)ccc1OCc1ccccc1>>Nc1ccc(-c2cc(C(F)(F)F)ccc2OCc2ccccc2)c(Cl)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US04356185,CC(=O)Oc1ccc(C(N)=S)cc1.O=C(O)CC(Br)Cc1ccc(Cl)cc1>>CC(=O)Oc1ccc(-c2nc(-c3ccc(Cl)cc3)c(CC(=O)O)s2)cc1,,CN(C)C=O,,,,val
US20150238473A1,CC(C)(C)c1ccccc1CCO.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCCc2ccccc2C(C)(C)C)cc1,,ClCCl,,,,val
US04623376,Cc1cc(-c2cccc(Cl)c2)nnc1Cl>>Cc1cnnc(-c2cccc(Cl)c2)c1,[Pd],CC(=O)O,,[H][H],,val
US20060229280A1,CCCCN(CCCCBr)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)OCC)[C@H]1c1ccc(OC)cc1.CNC>>CCCCN(CCCCN(C)C)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@H]1c1ccc(OC)cc1,,CCO,,,,val
US20130065880A1,CCOC(CCNC(=O)c1c[nH]c(-c2cc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)ccn2)c1)OCC>>Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)NCCC=O)c[nH]4)c3)cc2F)c1,,C1CCOC1,,Cl,O,val
US20110092423A1,Cn1nccc1-c1ncc(C(=O)N[C@@H](Cc2cccc(F)c2)CN2C(=O)c3ccccc3C2=O)s1>>Cn1nccc1-c1ncc(C(=O)N[C@H](CN)Cc2cccc(F)c2)s1,,C1CCOC1,CO,NN,,val
US20080207654A1,C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CCCc1nc(CC)n(-c2ccc(O)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O>>CCCc1nc(CC)n(-c2ccc(OCC3CCOCC3)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070010668A1,CC(=O)Nc1ccc(N)cc1.CNC(=O)c1ccccc1Nc1nc(Cl)ncc1[N+](=O)[O-].Cl>>CNC(=O)c1ccccc1Nc1nc(Nc2ccc(NC(C)=O)cc2)ncc1[N+](=O)[O-].Cl,,CC(C)O,,CCOCC,,val
US20060116382A1,CC(C)(C)OC(=O)N1CCCC2(CCN([C@@H]3CC[C@H](O)CC3)C2=O)C1.Cl>>Cl.O=C1N([C@@H]2CC[C@H](O)CC2)CCC12CCCNC2,,CCOC(C)=O,,,,val
US20050182045A1,COc1ccc(-n2c(C)cc3ccccc3c2=O)cc1>>Cc1cc2ccccc2c(=O)n1-c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US07902203B2,CS(=O)(=O)Nc1ccc(N)c(S(N)(=O)=O)c1.CSC(SC)=C1C(=O)C=CN(CC2CCC2)C1=O>>CS(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(c1c(O)ccn(CC3CCC3)c1=O)N2,,C1COCCO1,,,,val
US20080234262A1,C[C@H]1CN(c2nc(Cl)nc3c2cnn3C2CCNCC2)C[C@@H](C)O1.O=Cc1cccnc1>>C[C@H]1CN(c2nc(Cl)nc3c2cnn3C2CCN(Cc3cccnc3)CC2)C[C@@H](C)O1,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040009995A1,CNc1ccccn1.COC(=O)c1cc(S(=O)(=O)c2ccc(Br)c([N+](=O)[O-])c2)c(SC)s1>>COC(=O)c1cc(S(=O)(=O)c2ccc(NCc3ccccn3)c([N+](=O)[O-])c2)c(SC)s1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US04618634,CCNC1CC(C)(C)NC(C)(C)C1.O=C(Cl)CCl>>CCN(C(=O)CCl)C1CC(C)(C)NC(C)(C)C1,,ClCCl,O,[Na+].[OH-],,val
US20020082255A1,COc1cc(CC(=O)Nc2ccc(C(C)CC(=O)OC(C)(C)C)cc2)ccc1NC(=O)N1CCc2ccccc21>>COc1cc(CC(=O)Nc2ccc(C(C)CC(=O)O)cc2)ccc1NC(=O)N1CCc2ccccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120101127A1,CS(=O)(=O)Cl.Cc1ccc2c(c1)C(C)(C)CC(c1ccccc1N)N2>>Cc1ccc2c(c1)C(C)(C)CC(c1ccccc1NS(C)(=O)=O)N2,,ClCCl,O,c1ccncc1,,val
US20110269744A1,CCOC(=O)/C=C/c1cc2c(c(Cl)c1N)CCN(C(=O)OCC)CC2>>CCOC(=O)N1CCc2cc3c(c(Cl)c2CC1)NC(=O)CC3,O=[Pt]=O,CO,ClC(Cl)Cl,,,val
US04107310,O=C(O)c1cnc2ccccc2c1O.O=S(Cl)Cl>>O=C(Cl)c1cnc2ccccc2c1O,,c1ccccc1,,,,val
US05908841,Cc1ncccc1C(=O)N(C)c1cccnc1Cl.OO>>Cc1ncccc1C(=O)[N+](C)([O-])c1cccnc1Cl,,CC(=O)O,,,,val
US05726172,CCc1ncccc1CCl.O=C(OO)c1cccc(Cl)c1>>CCc1c(CCl)ccc[n+]1[O-],,ClC(Cl)Cl,,,,val
US20160002224A1,C[Si](C)(C)CCOCn1c(C(=O)O)cc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc21>>O=C(O)c1cc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc2n1CO,,C1CCOC1,,Cl,,val
US09296698B2,COC(=O)/C=C/c1cc2cc(Br)ccc2nc1NCc1ccc(OC)cc1>>COc1ccc(CNc2nc3ccc(Br)cc3cc2/C=C/C(=O)O)cc1,,C1CCOC1,CO,[Li+].[OH-],,val
US20090306066A1,C=O.C[C@H]1CN[C@H](C)CN1C(=O)OCc1ccccc1>>C[C@H]1CN(C)[C@H](C)CN1C(=O)OCc1ccccc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120208815A1,CC(C)(C)OC(=O)Nc1cc(-c2ccncc2N)nc(C(F)(F)F)n1.O=C(O)c1cccc(Br)n1>>CC(C)(C)OC(=O)Nc1cc(-c2ccncc2NC(=O)c2cccc(Br)n2)nc(C(F)(F)F)n1,,CN1CCCC1=O,,ClCCCl,On1nnc2cccnc21,val
US20080015199A1,COc1cc(C(Nc2ccc(C#N)cc2)c2nn(-c3ncccc3C(=O)O)c(=O)[nH]2)c(F)c2c1OCCCO2.[NH3+]O>>COc1cc(C(Nc2ccc(C(=N)NO)cc2)c2nn(-c3ncccc3C(=O)O)c(=O)[nH]2)c(F)c2c1OCCCO2,,CO,,CCN(CC)CC,,val
US20080167368A1,NC(=O)c1c[nH]cc1-c1ccc(N)cc1.O=C=Nc1cc(C(F)(F)F)ccc1F>>NC(=O)c1c[nH]cc1-c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1,,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20140303378A1,N#CC(C#N)CC(=O)c1ccccc1.Nc1ccc(S)cc1>>N#Cc1cc(-c2ccccc2)[nH]c1Sc1ccc(N)cc1,,O,,CO,,val
US20090318408A1,CCCN1C(=O)C(F)(F)CN(C2CCCC2)c2nc(Cl)ncc21.Nc1ccc(C(=O)O)cc1>>CCCN1C(=O)C(F)(F)CN(C2CCCC2)c2nc(Nc3ccc(C(=O)O)cc3)ncc21,,CCO,,Cl,,val
US04254122,COC(=O)N=C(N)SC.Cc1ccc(N=C=O)cc1>>CSC1NC(=O)N(c2ccc(C)cc2)C(=O)N1,,ClCCl,,Cl,C[O-].[Na+],val
US20050222139A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1cccc(C(=O)N2CCCc3ccccc32)c1>>CC(C)(C)OC(=O)NCc1cccc(C(=O)N2CCCc3ccccc32)c1,,ClCCl,,CCN(CC)CC,Cl,val
US20140323504A1,C=CC(=O)Cl.Cn1cc(Nc2ncc3cnn(Cc4cccc(N)c4)c3n2)cn1>>C=CC(=O)Nc1cccc(Cn2ncc3cnc(Nc4cnn(C)c4)nc32)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20130157996A1,Nc1ccc(C(=O)N[C@@H](c2ccc(OC(F)(F)F)c(F)c2)c2ncccc2F)nc1O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>O=C(N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)c1ncccc1F)c1ccc2[nH]c(=O)oc2n1,,C1CCOC1,CCCCCC,CCOC(C)=O,,val
US20100331326A1,Nc1ccc2ccccc2c1.O=C=NCCCl>>O=C(NCCCl)Nc1ccc2ccccc2c1,,Cc1ccccc1,ClC(Cl)Cl,CO,,val
US20140163186A1,CC(C)(C)c1ccc2[nH]c3ccc(C(C)(C)C)cc3c2c1.COCOc1ccc(C(C)(C)CC(C)(C)C)cc1I>>COCOc1ccc(C(C)(C)CC(C)(C)C)cc1-n1c2ccc(C(C)(C)C)cc2c2cc(C(C)(C)C)ccc21,[Cu]I,C1CCOC1,Cc1ccccc1,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US05707991,CC(C)(C)OC(=O)C1CC(C(=O)N2CCOCC2)C(c2ccccc2F)N1C(=O)CN.CCOC(=O)c1cccc(N=C=O)c1>>CCOC(=O)c1cccc(NC(=O)NCC(=O)N2C(C(=O)OC(C)(C)C)CC(C(=O)N3CCOCC3)C2c2ccccc2F)c1,,C1CCOC1,,,,val
US20120329785A1,CCN1CCN(c2ccc(N)cc2)CC1.COc1ccc(Cn2cc3c(n2)c(Cl)nc2cc(OC)ccc23)cc1>>CCN1CCN(c2ccc(Nc3nc4cc(OC)ccc4c4c[nH]nc34)cc2)CC1,C1COCCO1,CO,,Cl,,val
US20090192204A1,COc1ccc2[nH]c(C(=O)O)cc2c1.Nc1ncc([N+](=O)[O-])s1>>COc1ccc2[nH]c(C(=O)Nc3ncc([N+](=O)[O-])s3)cc2c1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US04515948,CCOC(=O)Nc1c(OC)cc(Cc2cnc(N)nc2N)cc1OC>>COc1cc(Cc2cnc(N)nc2N)cc(OC)c1N,,CCO,,[Na+].[OH-],,val
US04535183,CC(=O)Oc1cccc(OCc2ccccc2C(=O)O)c1C=O>>O=Cc1c(O)cccc1OCc1ccccc1C(=O)O,,CCO,,[Na+].[OH-],,val
US20030149043A1,CCOC(=O)c1cnn(-c2cc(C(=O)O)ccc2Cl)c1C1CC1.CN>>CCOC(=O)c1cnn(-c2cc(C(=O)NC)ccc2Cl)c1C1CC1,CN(C)c1ccncc1,ClCCl,O=S(Cl)Cl,,,val
US20070232583A1,CS(=O)(=O)Cl.Nc1cccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)c2)c1>>CS(=O)(=O)Nc1cccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)c2)c1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US04678792,C1=NCCc2ccccc21.ClCc1ccccc1Cl.O=S(=O)([O-])O>>Clc1ccccc1C[N+]1=Cc2ccccc2CC1.O=S(=O)([O-])O,,CC#N,,CC(C)O,,val
US20080023671A1,CCNCC.O=C(O)c1ccccc1>>CCN(CC)C(=O)c1ccccc1,,O,,O=S(Cl)Cl,,val
US20140296268A1,COC(=O)c1ccc(Oc2cc(N)nc(SC)n2)cc1.NN>>CSc1nc(N)cc(Oc2ccc(C(=O)NN)cc2)n1,,CO,,O,,val
US20110053916A1,Cc1nc(Br)nc(Br)c1C#C[Si](C)(C)C.Nc1cc(C2CC2)n[nH]1>>Cc1nc(Br)nc(Nc2cc(C3CC3)[nH]n2)c1C#C[Si](C)(C)C,,CCO,,,,val
US20070135385A1,CCCCCCCCCCCC(Br)Br.Cc1cc2c(OCC(=O)OCc3ccccc3)cccc2[nH]1>>Cc1cc2c(OCC(=O)OCc3ccccc3)cccc2n1CCCCCCCCCCCCBr,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20120101083A1,CCCNc1ncc(C(=O)O)cc1C#N.Cc1c(C(=N)NO)ccc2c1CCN(C(=O)OC(C)(C)C)CC2>>CCCNc1ncc(-c2nc(-c3ccc4c(c3C)CCN(C(=O)OC(C)(C)C)CC4)no2)cc1C#N,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090233817A1,CCCCCCCCCCCCCCCCCCCCCC(N)=O>>CCCCCCCCCCCCCCCCCCCCCCN,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
USRE029439,O=C(O)CCl.Sc1nc(-c2ccc(Cl)cc2)no1>>O=C(O)CSc1nc(-c2ccc(Cl)cc2)no1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20130029961A1,CC1CCN(c2nc(C(F)(F)F)ccc2CN)CC1.COCCOc1ccc(NC(=O)Oc2ccccc2)cn1>>COCCOc1ccc(NC(=O)NCc2ccc(C(F)(F)F)nc2N2CCC(C)CC2)cn1,,CC#N,,CCN(CC)CC,,val
US05719141,COC(=O)[C@H](CC1(COCc2ccccc2)CC1)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@H](CO)CC1(COCc2ccccc2)CC1,,C1CCOC1,,CO,[BH4-].[Li+],val
US20050148627A1,Cc1c(F)cccc1OC1CCCCO1>>Cc1c(O)cccc1F,,CO,,O=C(O)C(=O)O,,val
US06365594B1,CN1CC[C@]23c4c5ccc(O)c4OC2C(=O)CC[C@H]3[C@H]1C5.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CN1CC[C@]23c4c5ccc(OS(=O)(=O)C(F)(F)F)c4OC2C(=O)CC[C@H]3[C@H]1C5.[NH4+].[OH-],,c1ccncc1,,,,val
US06566344B1,CC(=O)O[C@@H]1O[C@H](COC(=O)c2ccccc2)[C@@H](OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1>>CC(=O)O[C@H]1O[C@@H](COC(=O)c2ccccc2)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1,,CCO,,,,val
US20160168139A1,BrC(Br)(Br)Br.OCc1ccc2c(c1)Cc1cccc(Br)c1O2>>BrCc1ccc2c(c1)Cc1cccc(Br)c1O2,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06384041B1,BrCc1ccccc1.CCc1cc2c(Cl)nc(SC)[nH]c-2n1>>CCc1cc2c(Cl)nc(SC)nc2n1Cc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20160108047A1,COc1ncc(B(O)O)c(OC)n1.Cc1noc2c(C)cc(N3C(=O)c4nc(Br)n(C(C)C)c4C3c3ccc(Cl)cc3)cc12>>COc1ncc(-c2nc3c(n2C(C)C)C(c2ccc(Cl)cc2)N(c2cc(C)c4onc(C)c4c2)C3=O)c(OC)n1,,CN(C)C=O,,CCOC(C)=O,CO,val
US20110009401A1,COC(=O)C(C=O)NC(C)=O>>COC(=O)c1coc(C)n1,,ClC(Cl)Cl,,O=S(Cl)Cl,,val
US20070197641A1,CCCC(Oc1ccc(C#N)c(Cl)c1)C(=O)NCCc1ccc(O)cc1>>CCC[C@H](Oc1ccc(C#N)c(Cl)c1)C(=O)NCCc1ccc(O)cc1,,O,,,,val
US20160193218A1,CC(C)N1CCC(Nc2cccc(C=O)c2)CC1.COc1cc(N)c(C(N)=O)c(OC)c1>>COc1cc(OC)c2c(=O)[nH]c(-c3cccc(NC4CCN(C(C)C)CC4)c3)nc2c1,,CC(=O)N(C)C,,O=S([O-])O.[Na+],,val
US20090137557A1,COc1c(F)cccc1-c1nc2c(c(=O)n1CCc1ccccc1)CCCC2>>O=c1c2c(nc(-c3cccc(F)c3O)n1CCc1ccccc1)CCCC2,,ClCCl,,BrB(Br)Br,,val
US05821255,CCCN(c1nc(-c2ccc(Cl)cc2Cl)c(C)s1)C(c1ccc(CO)cc1)C1CC1.II>>CCCN(c1nc(-c2ccc(Cl)cc2Cl)c(C)s1)C(c1ccc(CI)cc1)C1CC1,,ClCCl,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030149027A1,CC(C)(C)OC(=O)NCc1ccc(Nc2ccccc2[N+](=O)[O-])cc1>>CC(C)(C)OC(=O)NCc1ccc(Nc2ccccc2N)cc1,[Pd],CCO,,,,val
US20150183804A1,Br.BrBr.CC(=O)c1ccc(OCCF)nc1>>Br.O=C(CBr)c1ccc(OCCF)nc1,,CC(=O)O,,,,val
US20120010191A1,Cn1cc(Br)cc(Nc2ccc3c(n2)CCN(C(=O)OC(C)(C)C)C3)c1=O>>Cn1cc(Br)cc(Nc2ccc3c(n2)CCNC3)c1=O,,C1COCCO1,ClCCl,Cl,,val
US04704388,COC(=N)NC(=O)OC.O=S(=O)(Cl)NC1CCCCC1>>COC(=N)N(C(=O)OC)S(=O)(=O)NC1CCCCC1,,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20100324068A1,COC(=O)Cc1ccc(-c2ccc(-c3nc(C(N)=O)c(C)nc3C)cc2F)c(F)c1>>Cc1nc(C)c(-c2ccc(-c3ccc(CC(=O)O)cc3F)c(F)c2)nc1C(N)=O,,CC(C)(C)O,,Cl,[K+].[OH-],val
US20130150360A1,CC(=O)OCc1c(-c2cnnc(Nc3ccc(C(=O)N4CCOCC4)cn3)c2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O>>CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-c4cnnc(Nc5ccc(C(=O)N6CCOCC6)cn5)c4)c3CO)ncc2c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150152117A1,COc1ccc(Cl)cc1-c1nn(COCC[Si](C)(C)C)cc1[N+](=O)[O-]>>COc1ccc(Cl)cc1-c1nn(COCC[Si](C)(C)C)cc1N,[Fe],CCO,ClCCl,O,[Cl-].[NH4+],val
US04245088,CC(=O)CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1.Cn1nnnc1S>>Cn1nnnc1SCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1,,O,,O=C([O-])O.[Na+],,val
US05698692,CCN=C=O.O=C(O)C(F)(F)F.O=C(O)COc1ccc(C(=O)CNC(=O)c2cc3c(s2)CCNC3)cc1OCc1ccccc1>>CCNC(=O)Oc1cc(C(=O)CNC(=O)c2cc3c(s2)CCNC3)ccc1OCC(=O)O.O=C(O)C(F)(F)F,,CN(C)C=O,O,CCN(CC)CC,Cl,val
US20130059834A1,CC[C@H](CO)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12>>CC[C@H](CO)NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US20120202867A1,CON=C(C)C1CC1c1c(Cl)cc(Cl)cc1Cl>>CONC(C)[C@@H]1C[C@H]1c1c(Cl)cc(Cl)cc1Cl,,CCO,,CC(=O)O,[BH3-]C#N.[Na+],val
US05808062,Cc1ccc(COS(=O)(=S)c2ccc(C)cc2)cc1.O=c1oc(-c2ccccc2)cc(O)c1SSc1c(O)cc(-c2ccccc2)oc1=O>>Cc1ccc(CSc2c(O)cc(-c3ccccc3)oc2=O)cc1,,CCO,,[Na+].[OH-],,val
US20020090728A1,CC(C)(C)OC(=O)N[C@@H](C(=O)O)C(C)(C)C.Fc1nc(F)nc(F)n1>>CC(C)(C)OC(=O)N[C@@H](C(=O)F)C(C)(C)C,,ClCCl,,c1ccncc1,,val
US05929085,Cl.O=[N+]([O-])c1ccc2c(c1)CN1CCCCC1C2>>Cl.Nc1ccc2c(c1)CN1CCCCC1C2,[Pd],CCO,,,,val
US04469693,CC(C)(C)C(=O)Cl.O=c1cccccc1N1CCN(CCO)CC1>>CC(C)(C)C(=O)OCCN1CCN(c2cccccc2=O)CC1,,ClCCl,,CCN(CC)CC,,val
US20040209865A1,CN(CCOc1ccc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)cc1)C1CCN(C(=O)OC(C)(C)C)CC1>>CN(CCOc1ccc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)cc1)C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030013733A1,N#CC(c1ccc(Br)cc1)N1CCCCC1CCCl>>N#CC1(c2ccc(Br)cc2)CCC2CCCCN21,,CN(C)C=O,O,[H-].[Na+],,val
US20060100229A1,CCOC(=O)C(=O)CC(=O)CC.NN>>CCOC(=O)c1cc(CC)[nH]n1,,CC(=O)O,,,,val
US20160271270A1,CC(=O)Cl.Cc1csc2c(O)cc3c(c12)[C@H](CCl)CN3C(=O)OC(C)(C)C>>CC(=O)Oc1cc2c(c3c(C)csc13)[C@H](CCl)CN2C(=O)OC(C)(C)C,,ClCCl,,c1ccncc1,,val
US20150329533A1,CC(C)Cc1cc(CN)nn1-c1ccccc1.O=S(=O)(Cl)Cc1ccc2ccccc2c1>>CC(C)Cc1cc(CNS(=O)(=O)Cc2ccc3ccccc3c2)nn1-c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US06710057B2,NCC1CCN(c2ccncc2)CC1.O=[N+]([O-])c1ccccc1F>>O=[N+]([O-])c1ccccc1NCC1CCN(c2ccncc2)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20120328540A1,CC(C)=CCC/C(C)=C/CC/C(C)=C/CSC[C@H](N)C(=O)O.O=C1C=CC(=O)O1>>CC(C)=CCC/C(C)=C/CC/C(C)=C/CSC[C@H](NC(=O)/C=C/C(=O)O)C(=O)O,,C1CCOC1,,Cl,O=C([O-])[O-].[K+].[K+],val
US05972988,COc1cccc2[nH]c(C)cc12.ClCc1cccc(-c2ccccc2)c1>>COc1cccc2c1cc(C)n2Cc1cccc(-c2ccccc2)c1,,CN(C)C=O,O,CCCCCC,[H-].[Na+],val
US20080166359A1,COC(=O)C1CSCC1=O.Nc1ccc(I)cc1F>>COC(=O)C1=C(Nc2ccc(I)cc2F)CSC1,CC(=O)O,CCO,,,,val
US20110021522A1,COc1cccc2cc(C(=O)O)c(=O)oc12.Cn1nccc1-c1cccc(N)c1>>COc1cccc2cc(C(=O)Nc3cccc(-c4ccnn4C)c3)c(=O)oc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100216746A1,[N-]=[N+]=NCc1ccc(Cl)c(Oc2cc(Br)cc(F)c2Cl)c1F>>NCc1ccc(Cl)c(Oc2cc(Br)cc(F)c2Cl)c1F,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120149699A1,CCOC(=O)C(=O)C(C)Br.Nc1ccccn1>>CCOC(=O)c1nc2ccccn2c1C,,COCCOC,,,,val
US20080139631A1,BrCc1noc(-c2cccs2)n1.CCCc1cc2c(C(F)(F)F)c(C#N)ccc2[nH]1>>CCCc1cc2c(C(F)(F)F)c(C#N)ccc2n1Cc1noc(-c2cccs2)n1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090264445A1,CC1CC(C=O)C1.COC(=O)C(NC(=O)OCc1ccccc1)P(=O)(O)O>>COC(=O)/C(=C/C1CC(C)C1)NC(=O)OCc1ccccc1,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US05362736,CN=C=O.COc1cccc(CC2NCCc3cc(OC)c(OC)c(O)c32)c1>>CNC(=O)N1CCc2cc(OC)c(OC)c(O)c2C1Cc1cccc(OC)c1,,ClCCl,,,,val
US06093838,CC(=O)Cl.Cc1cc2c(cc1Br)C(C)(C)CO2>>CC(=O)c1c(C)c(Br)cc2c1OCC2(C)C,,ClCCl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20140161740A1,C=C(C)C(=C)C.C=CC#N>>CC1=C(C)CC(C#N)CC1,,Cc1ccccc1,,,,val
US20050256103A1,C=CCc1cc([N+](=O)[O-])c(CO)cc1O.CI>>C=CCc1cc([N+](=O)[O-])c(CO)cc1OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090023781A1,CCOC(=O)C(F)(F)Br.Oc1cccnc1>>CCOC(=O)C(F)(F)Oc1cccnc1,,CCOCC,,[H-].[Na+],,val
US20150368228A1,CC(C)(C)OC(=O)N1CC=C(c2c(Cl)cc(N=C=S)cc2Cl)CC1.CI.N#CN>>CS/C(=N\c1cc(Cl)c(C2=CCN(C(=O)OC(C)(C)C)CC2)c(Cl)c1)NC#N,,CO,,C[O-].[Na+],,val
US20080292585A1,CN(C)CCN1C(=O)c2cccc3cc4c(N)cccc4c(c23)C1=O.O=Cc1cc(O)ccc1O>>CN(C)CCN1C(=O)c2cccc3cc4c(/N=C\c5cc(O)ccc5O)cccc4c(c23)C1=O,,CO,ClCCl,Cc1ccccc1,,val
US20140206618A1,COc1cc([C@@H]2CN3CCN(C(=O)OC(C)(C)C)C[C@@H]3CO2)ccc1C#N.Cl>>COc1cc([C@@H]2CN3CCNC[C@@H]3CO2)ccc1C#N.Cl,,C1COCCO1,,,,val
US20060241083A1,CC(C)(C)OP(=O)(OC(C)(C)C)C(O)c1cnc2ccccc2c1>>O=P(O)(O)C(O)c1cnc2ccccc2c1,,CC(=O)O,O,,,val
US20080269196A1,CC(C)(C)C(=O)Nc1ccc(C#N)cc1.CI>>CN(C(=O)C(C)(C)C)c1ccc(C#N)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20110021537A1,CCCCOC(=O)Cl.O=C(NC1CCNC1)OCc1ccccc1>>CCCCOC(=O)N1CCC(NC(=O)OCc2ccccc2)C1,,ClCCl,,CCN(CC)CC,,val
US20040014776A1,Clc1cccc(Nc2nccc(-c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)n2)c1.O=C1c2ccccc2C(=O)N1CCOS(=O)(=O)C(F)(F)F>>O=C1c2ccccc2C(=O)N1CCn1cncc1-c1ccnc(Nc2cccc(Cl)c2)n1,,ClCCl,,,,val
US20110118245A1,CC(C)(C#N)c1cccc(N)c1.O=C(Cl)Oc1ccccc1>>CC(C)(C#N)c1cccc(NC(=O)Oc2ccccc2)c1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20080305956A1,COCCS.Cc1c(C(=O)O)ccc(C(F)(F)F)c1F>>COCCSc1c(C(F)(F)F)ccc(C(=O)O)c1C,,CN(C)C=O,,[H-].[Na+],,val
US20140275172A1,BrBr.COC(=O)c1cc(Cl)ccc1O>>COC(=O)c1cc(Cl)cc(Br)c1O,,CO,,,,val
US20020040029A1,COc1cccc(OC)c1C(C)=O.O=Cc1ccccc1>>COc1cccc(OC)c1C(=O)C=Cc1ccccc1,,CO,O,[Na+].[OH-],,val
US20090149454A1,COc1cc2nccc(Oc3ccc4c(c3)OCCN4)c2cc1O.Cc1cc(NC(=O)Oc2ccc([N+](=O)[O-])cc2)no1>>COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3cc(C)on3)c2cc1O,,C1CCOC1,,CCN(CC)CC,,val
US20080090834A1,CN(C)C=C(C(=O)c1ccc(-n2ccc3cccnc32)cc1)c1cccnc1.NN>>c1cncc(-c2c[nH]nc2-c2ccc(-n3ccc4cccnc43)cc2)c1,,CO,,O,,val
US04341698,CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN1CCN(C(=O)OC(C)(C)C)C(Cc2ccc(OCc3ccccc3)cc2)C1=O>>CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN1CCN(C(=O)OC(C)(C)C)C(Cc2ccc(O)cc2)C1=O,[Pd],CCO,,[H][H],,val
US20050148648A1,COc1ccc(C2(CN)CCCC2)cc1OC.O=C(O)CSc1ccccc1>>COc1ccc(C2(CNC(=O)CSc3ccccc3)CCCC2)cc1OC,,CC#N,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090099213A1,CN(CC(c1ccc(Cl)cc1)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)C(=O)OC(C)(C)C.Clc1ccnc2[nH]ccc12>>CN(CC(c1ccc(Cl)cc1)c1ccc(-c2ccnc3[nH]ccc23)cc1)C(=O)OC(C)(C)C,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US05240938,BrC(Br)(Br)Br.CCOC(=O)C(O)c1ccccc1C>>CCOC(=O)C(Br)c1ccccc1C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130261100A1,COC(=O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3N3CC(Oc4cccc(N5CCNCC5)c4)C3)CC2)cc1>>O=C(O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3N3CC(Oc4cccc(N5CCNCC5)c4)C3)CC2)cc1,,C1COCCO1,O,Cl,[Na+].[OH-],val
US04918107,O=S(Cl)Cl.OCc1ccc(OCc2ccccc2)cc1OCc1ccccc1>>ClCc1ccc(OCc2ccccc2)cc1OCc1ccccc1,,c1ccccc1,,,,val
US20100041711A1,CC(C)(C(=O)O)c1ccccc1>>CC(C)(CO)c1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05071844,COc1ccc(CCN2CCC[C@H]2CN2c3ccccc3CSc3ccccc32)cc1.Cc1ccc(S(=O)(=O)OC[C@@H]2CCCN2S(=O)(=O)c2ccc(C)cc2)cc1>>Cc1ccc(S(=O)(=O)N2CCC[C@H]2CN2c3ccccc3CSc3ccccc32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20150011527A1,CC(C)(C)c1ccc(C(=O)N[C@@H](Cc2ccc(-c3ncc(Br)cn3)cc2)C(=O)O)s1.C[C@@H](N)C(=O)OC(C)(C)C>>C[C@@H](NC(=O)[C@H](Cc1ccc(-c2ncc(Br)cn2)cc1)NC(=O)c1ccc(C(C)(C)C)s1)C(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070185168A1,CC(C)(C)[Si](C)(C)Cl.O=C1CCCc2cc(C(O)CCl)ccc2N1>>CC(C)(C)[Si](C)(C)OC(CCl)c1ccc2c(c1)CCCC(=O)N2,,CN(C)C=O,,c1c[nH]cn1,,val
US20110183979A1,COCc1ccc(Br)c[n+]1[O-].C[Si](C)(C)C#N>>COCc1ccc(Br)c(C#N)n1,,CC#N,,CCN(CC)CC,O,val
US20120264735A1,CC1(C)OB(c2cccc(N)c2)OC1(C)C.CCOC(=O)Cl>>CCOC(=O)Nc1cccc(B2OC(C)(C)C(C)(C)O2)c1,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,,val
US20120083488A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc3c(c2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)CC1>>CC1(C)c2cc(OC3CCNCC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21,,C1CCOC1,,O=C(O)C(F)(F)F,,val
US20010027196A1,N#Cc1c(Cl)nc(N)nc1OCc1ccccn1.OCc1ccccn1>>N#Cc1c(OCc2ccccn2)nc(N)nc1OCc1ccccn1,,COCCOC,,C1CCC2=NCCCN2CC1,O,val
US04372953,Cn1nnnc1SCCCN1C(=O)c2ccccc2C1=O>>Cn1nnnc1SCCCN,,CCO,,NN,O,val
US20130203739A1,Cc1cccc(C)c1-c1cccc(CO)c1.O=Cc1ccc(O)cc1>>Cc1cccc(C)c1-c1cccc(COc2ccc(C=O)cc2)c1,,C1CCOC1,Cc1ccccc1,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070191340A1,BrCc1ccc(Br)cc1.c1ccc(CC2CNCCO2)cc1>>Brc1ccc(CN2CCOC(Cc3ccccc3)C2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060258714A1,CN.Cc1ccc(S(=O)(=O)OCC2C=Cc3cc(F)cc(-c4ccccc4Cl)c3O2)cc1>>CNCC1C=Cc2cc(F)cc(-c3ccccc3Cl)c2O1,,CS(C)=O,,[Na+].[OH-],,val
US06333414B1,O=C(O)CCCOCc1ccccc1.O=C(c1ccccc1)C(O)c1ccccc1>>O=C(CCCOCc1ccccc1)OC(C(=O)c1ccccc1)c1ccccc1,CN(C)C=O,Cc1ccccc1,ClCCl,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US04556677,CCC(C(=O)c1ccc(O)cc1)C1CCCC1.CN(C)CCOc1ccc(Br)cc1>>CCC(C1CCCC1)C(O)(c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1,,CCO,,Cl,,val
US20140221343A1,CC(C)(C)C=O.NCCn1c(Sc2cc3c(cc2Br)OCO3)nc2c(N)nccc21>>CC(C)(C)CNCCn1c(Sc2cc3c(cc2Br)OCO3)nc2c(N)nccc21,,CO,,[BH3-]C#N.[Na+],,val
US04374773,CC(=O)NN.CC1(C)N=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc2NC1=O>>Cc1nnc2n1-c1ccc([N+](=O)[O-])cc1C(c1ccccc1F)=NC2(C)C,,C1CCOC1,,[H-].[Na+],,val
US20140371278A1,O=C(OCc1ccccc1)c1cc(OCc2ccccc2)c(F)c(F)c1Nc1ccccc1Cl.[N-]=[N+]=[N-]>>[N-]=[N+]=Nc1c(OCc2ccccc2)cc(C(=O)OCc2ccccc2)c(Nc2ccccc2Cl)c1F,,CN(C)C=O,,O,,val
US20030186962A1,CON(C)C(=O)C(NC(=O)OCc1ccccc1)C(C)COC(C)(C)C>>CC(COC(C)(C)C)C(C=O)NC(=O)OCc1ccccc1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080300266A1,CC(C)(C)OC(=O)N[C@H]1CCNC1.Fc1ccc(Br)cn1>>CC(C)(C)OC(=O)N[C@H]1CCN(c2ccc(F)nc2)C1,,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1,O=C([O-])[O-].[Cs+].[Cs+],val
US05183653,Nc1cc(B(O)O)cc(C(=O)O)c1.S=C(Cl)Cl>>O=C(O)c1cc(N=C=S)cc(B(O)O)c1,,Cl,,,,val
US20140275508A1,C[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](CO[Si](C)(C)C(C)(C)C)Cn1ccc(=O)[nH]c1=O.c1nc[nH]n1>>C[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](CO[Si](C)(C)C(C)(C)C)Cn1ccc(-n2cncn2)nc1=O,,c1ccncc1,,,,val
US20150266867A1,CC(C)(C)OC(=O)NCc1ncnn1C[C@@H]1[C@H](NC(=O)/C(=N\OC(C)(C)C(=O)OC(C)(C)C)c2csc(NC(=O)OC(C)(C)C)n2)C(=O)N1S(=O)(=O)O>>CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N(S(=O)(=O)O)[C@@H]1Cn1ncnc1CN)c1csc(N)n1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050288293A1,O=C1CN(C(=O)OCc2ccccc2)CCN1Cc1ccccc1>>O=C1CNCCN1Cc1ccccc1,[Pd],CCO,,,,val
US20130324553A1,Cc1cc(C(F)(F)F)nn1CC(=O)O.Nc1cccc(C2CCNCC2)c1>>Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2cccc(N)c2)CC1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20110021520A1,C[C@](N)(C(=O)O)c1cc(Br)cc([N+](=O)[O-])c1>>C[C@](N)(CO)c1cc(Br)cc([N+](=O)[O-])c1,,CCOC(C)=O,,C1CCOC1,,val
US20120129840A1,CCCC(C(=O)OC)c1c(C)nc(Cl)nc1-c1ccc(C)cc1.c1ccc2c(c1)CCNC2>>CCCC(C(=O)OC)c1c(C)nc(N2CCc3ccccc3C2)nc1-c1ccc(C)cc1,,C1CCOC1,,CCN(CC)CC,,val
US04301295,CCOC(=O)CCl.Cc1ccc(Sc2ccc(O)cc2)cc1>>CCOC(=O)COc1ccc(Sc2ccc(C)cc2)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080275259A1,C[C@]12CC[C@H]3[C@@H](CC(CO)C4=CC(=O)C=C[C@@]43C)[C@@H]1CCC2=O>>C=C1C[C@H]2[C@@H]3CCC(=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)C=CC(=O)C=C12,,CCOC(C)=O,,,,val
US05990133,CC(=O)N1CCc2cc(S)c(C(F)(F)F)cc21.CI>>CSc1cc2c(cc1C(F)(F)F)N(C(C)=O)CC2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160264552A1,CNC.N#Cc1cnc(NC2CCN(C(=O)c3ccc(N)cc3)CC2)nc1-c1c[nH]c2ccccc12.O=C(Cl)/C=C/CBr>>CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CCC(Nc3ncc(C#N)c(-c4c[nH]c5ccccc45)n3)CC2)cc1,,C1CCOC1,CN(C)C=O,CCN(C(C)C)C(C)C,ClCCl,val
US20100267712A1,CCOC(=O)c1cc(OC(F)F)ccc1CBr.Cn1ccc2cc(N)ccc21>>Cn1ccc2cc(N3Cc4ccc(OC(F)F)cc4C3=O)ccc21,,CCO,,CCN(C(C)C)C(C)C,,val
US20130079313A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)CNCc1ccc(OC)c(OC)c1>>CCOC(=O)CN(Cc1ccc(OC)c(OC)c1)C(=O)OC(C)(C)C,,ClCCl,,,,val
US20040167128A1,CCN(CC)CCC/C=C\c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)OC)CCCC2>>CCN(CC)CCCCCc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)OC)CCCC2,[Pd],CO,,,,val
US20060069088A1,CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)ccc2OC(C)(C)C)C=CC(N)C1.CCOC(=O)C(=O)C(=O)OCC>>CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)ccc2OC(C)(C)C)C=CC(=O)C1,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,,val
US04272507,CCOC(=O)C(=O)Cl.Clc1cccc(Cl)c1Nc1ccsc1>>CCOC(=O)C(=O)c1sccc1Nc1c(Cl)cccc1Cl,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,O,val
US20120149910A1,CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1N.O=C(Cl)c1ccc(CCl)cc1>>CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1ccc(CCl)cc1,CN(C)c1ccncc1,C1CCOC1,O,c1ccncc1,,val
US06291640B1,C[C@H](NC(=O)OCc1ccccc1)C(O)c1nc2ccccc2o1.Cc1ccc(N)c(O)c1>>Cc1ccc2nc(C(O)[C@H](C)NC(=O)OCc3ccccc3)oc2c1,,CCOC(C)=O,,[Br-].[K+],,val
US20120040897A1,CC(C)(C)OC(=O)N1CCC(CO)(NC(=O)OCc2ccccc2)CC1.CCN(CC)S(F)(F)F>>CC(C)(C)OC(=O)N1CCC(CF)(NC(=O)OCc2ccccc2)CC1,,ClCCl,,O,,val
US20100210647A1,COc1ccc(CO)cc1.N[C@@H](CS)C(=O)O>>COc1ccc(CSC[C@H](N)C(=O)O)cc1,,CCO,CCOCC,Cl,[Na+].[OH-],val
US20140348748A1,CCOCCl.Oc1ccc2nc(Br)sc2c1>>CCOCOc1ccc2nc(Br)sc2c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040229903A1,CCOC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(C(C)=O)cc3)ccn2c1=O>>CCOC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(C(C)O)cc3)ccn2c1=O,,CCO,,O,[BH4-].[Na+],val
US04228168,CCNCCc1c[nH]c2ccccc12.COC(=O)CCCC(=O)Cl>>CCN(CCc1c[nH]c2ccccc12)C(=O)CCCC(=O)OC,,c1ccncc1,,Cl,,val
US06150372,CSc1ccc2nc(C(F)(F)F)nc(Cl)c2c1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ccc2nc(C(F)(F)F)nc(Cl)c2c1,,ClC(Cl)Cl,,,,val
US09273028B2,CNC1COCCN(C(=O)OC(C)(C)C)C1.Cc1ccc(S(=O)(=O)n2ccc3c(Cl)ncnc32)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c(N(C)C4COCCN(C(=O)OC(C)(C)C)C4)ncnc32)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20090186898A1,CCC#CCN(C)C.Cc1c(N)cccc1B1OC(C)(C)C(C)(C)O1.O=C(Cl)Cl>>Cc1c(NC(=O)NCC#CC(C)(C)C)cccc1B1OC(C)(C)C(C)(C)O1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,ClCCl,val
US20100286114A1,CC(C)(C)OC(=O)n1c(-c2cc(N3CCC4(CC3)OCCO4)ccc2Cl)nc2ccccc21>>O=C1CCN(c2ccc(Cl)c(-c3nc4ccccc4[nH]3)c2)CC1,,C1CCOC1,,Cl,,val
US20060235057A1,CCOC(=O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2O)c1.OCCc1ccccc1>>CCOC(=O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCCc2ccccc2)c1,,C1CCOC1,O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140135277A1,C=CCOC[C@@H]1[C@@H](OCC=C)[C@H](OCC=C)[C@@H](OCC=C)[C@H](c2ccc(Cl)c(Cc3ccc(OCC)cc3)c2)N1C>>C/C=C/OC[C@@H]1[C@@H](O/C=C/C)[C@H](O/C=C/C)[C@@H](O/C=C/C)[C@H](c2ccc(Cl)c(Cc3ccc(OCC)cc3)c2)N1C,,C1CCOC1,,,,val
US20110172428A1,CC(=O)O.O=C1C(=O)N(N=Cc2ccccc2)c2ccccc21>>O=C(O)c1n[nH]c2ccccc12,,O,,Cl,,val
US20110124665A1,COC(=O)CCBr.COc1ccc(-c2c(-c3ccccc3)oc3ncnc(OC4CCCNC4)c23)cc1>>COC(=O)CCN1CCCC(Oc2ncnc3oc(-c4ccccc4)c(-c4ccc(OC)cc4)c23)C1,,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20160168090A1,BrCC1CCCO1.Clc1cccc2[nH]ccc12>>Clc1cccc2c1ccn2CC1CCCO1,,CCOC(C)=O,CN(C)C=O,[K+].[OH-],,val
US06432993B1,CN(C(=O)OC(C)(C)C)c1cc(Oc2ccc(Oc3ccccc3)cc2)ccc1[N+](=O)[O-]>>CN(C(=O)OC(C)(C)C)c1cc(Oc2ccc(Oc3ccccc3)cc2)ccc1N,[Pd],CO,Cc1ccccc1,,,val
US04371720,O=C1CCCCC(O)C1>>O=C1CCCCC(=O)C1,,CC(C)=O,,,,val
US05795891,C=C(C)C.CC(C)C[C@@H](Br)C(=O)O>>CC(C)C[C@@H](Br)C(=O)OC(C)(C)C,,ClCCl,,O=S(=O)(O)O,,val
US06599917B1,COc1cc(C(=O)c2ccccc2)ccn1>>COc1cc(C(O)c2ccccc2)ccn1,,O,,CO,[BH4-].[Na+],val
US20060173049A1,NCc1cccc(N)n1.O=C(CCC(=O)c1ccccc1)c1ccccc1>>Nc1cccc(Cn2c(-c3ccccc3)ccc2-c2ccccc2)n1,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US20140349998A1,C=C(CO)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1.CCN(CC)S(F)(F)F>>C=C(CF)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1,,CS(C)=O,,ClCCl,,val
US20010018099A1,BrCC=CCBr.Oc1cccc(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c1>>FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)c1cccc(OCC=CCBr)c1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US04537891,CSc1ncc(Cc2ccc(O)cc2)c(=O)[nH]1.Cc1cc(Br)cnc1CCCCN>>Cc1cc(Br)cnc1CCCCNc1ncc(Cc2ccc(O)cc2)c(=O)[nH]1,,c1ccncc1,,,,val
US20110046132A1,COCCOCCl.COc1cc2[nH]cnc2cc1Cl>>COCCOCn1cnc2cc(Cl)c(OC)cc21,,CCOC(C)=O,,C1CCOC1,CCN(C(C)C)C(C)C,val
US04927938,CC(=O)c1cnc(O)c(Cl)c1.O=P(Cl)(Cl)Cl>>CC(=O)c1cnc(Cl)c(Cl)c1,,Clc1ccccc1,,CN(C)c1ccccc1,,val
US04603130,CCCBr.CCOCCn1c(CN2CCNCC2)nc2ccccc21>>CCCN1CCN(Cc2nc3ccccc3n2CCOCC)CC1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US04912231,COC(=O)[C@@H]1C[C@H](O)CN1C(=O)OCc1ccccc1.Cl>>COC(=O)[C@@H]1C[C@H](O)CN1.Cl,[Pd],CO,,,,val
US20090312388A1,CCOC(=O)Cc1ccc(N2C(=O)c3c(c(OCC)c4ccccc4c3O)C2=O)c(Cl)c1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CCOC(=O)Cc1ccc(N2C(=O)c3c(c(OCC(F)(F)F)c4ccccc4c3OCC)C2=O)c(Cl)c1,,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20070049616A1,CB1OB(C)OB(C)O1.N#Cc1ccc(Br)c(OC(F)(F)F)c1>>Cc1ccc(C#N)cc1OC(F)(F)F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04808762,CC(C)[C@H]1COC(=O)N1.O=C(Cl)C(c1ccc(Cl)cc1)C1CC1>>CC(C)[C@H]1COC(=O)N1C(=O)C(c1ccc(Cl)cc1)C1CC1,,C1CCOC1,,O,[Li]CCCC,val
US20090181950A1,COC(=O)C=Cc1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1.O=CO>>O=C(O)/C=C/c1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1.O=CO,,C1CCOC1,,[Na+].[OH-],,val
US20060063779A1,C1CCNCC1.O=C(Nc1ccc(Cl)c(-c2ccccn2)c1)c1ccc(CBr)cc1>>O=C(Nc1ccc(Cl)c(-c2ccccn2)c1)c1ccc(CN2CCCCC2)cc1,,CS(C)=O,,,,val
US20160185780A1,CC(C)(C)OC(=O)N1CCC(C#N)(c2ccc(CO)cc2)CC1>>CC(C)(C)OC(=O)N1CCC(C#N)(c2ccc(C=O)cc2)CC1,,ClCCl,,O=C([O-])O.[Na+],,val
US20150342908A1,C=CCBr.COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C>>C=CCN(C)CCc1cc(O)c(OC)c2c1ccc1cc(O)c(OC)cc12,,CN(C)C=O,,,,val
US20160200695A1,CI.O=C(Nc1cccc(F)c1)c1sc2ccccc2c1Cl>>CN(C(=O)c1sc2ccccc2c1Cl)c1cccc(F)c1,,CN(C)C=O,,[H-].[Na+],,val
US20050261295A1,CC(=O)Nc1cccc(F)c1C=O.Cc1ccccc1[Mg]Br>>CC(=O)Nc1cccc(F)c1C(O)c1ccccc1C,,C1CCOC1,CCOCC,,,val
US20160159774A1,COc1ccc(CNc2ccc3c(c2)CCN(C(C)(C)C)C3)cc1>>CC(C)(C)N1CCc2cc(N)ccc2C1,,O=C(O)C(F)(F)F,,,,val
US20070093476A1,CCOC(=O)C(C)(C)Oc1ccc(CCCOS(C)(=O)=O)cc1.Oc1ccc(-c2ccccc2)cc1>>CCOC(=O)C(C)(C)Oc1ccc(CCCOc2ccc(-c3ccccc3)cc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100324086A1,CC(C)(C)OC(=O)Nc1cccc(C(=O)O)c1.Nc1ccc2ccccc2n1>>CC(C)(C)OC(=O)Nc1cccc(C(=O)Nc2ccc3ccccc3n2)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04055597,CCCCC[C@@H](CCCO)OC1CCCCO1.CS(=O)(=O)Cl>>CCCCC[C@@H](CCCOS(C)(=O)=O)OC1CCCCO1,,CCOCC,,c1ccncc1,,val
US20090030038A1,BrBr.COc1cccc2c1C[C@@H](N(C)C)CC2>>COc1ccc(Br)c2c1C[C@@H](N(C)C)CC2,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20090275624A1,COc1ccc(CNCCCNC2=CC(=O)c3sc(C)nc3C2=O)cc1.Cc1nc2c(s1)C(=O)C=C(NCCCBr)C2=O>>COc1ccc(CN(CCCNC2=CC(=O)c3sc(C)nc3C2=O)CCCNC2=CC(=O)c3sc(C)nc3C2=O)cc1,,CC#N,,CCN(C(C)C)C(C)C,[I-].[Na+],val
US20100305122A1,CC(=O)Cl.CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](N)CC1>>CC(=O)N[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1,,ClCCl,,CCN(CC)CC,,val
US04126689,CCCI.O=C(Cc1ccc(Cl)cc1)N(c1ccc(Cl)cc1)C1CCNCC1>>CCCN1CCC(N(C(=O)Cc2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1,,CCCCO,,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20040044057A1,C=CCBr.CCOCC.CN(C)C=O.O=C1c2ccccc2CC1O.O=C1c2ccccc2CCC1O>>CCN(CC)c1ccccc1.O=C1CCc2ccccc21,,CCOCC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100036150A1,COC(=O)C(O)c1ccc(O)cc1.ClCc1ccc(Cl)c(Cl)c1>>COC(=O)C(O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1,,CN(C)C=O,,[I-].[K+],,val
US20160102058A1,COCOC1CCC(C(=O)C2CCCCC2)CC1>>COCOC1CCC(C(O)C2CCCCC2)CC1,,CO,,[BH4-].[Na+],,val
US20090124666A1,OCc1ccc(C(F)F)cc1>>O=Cc1ccc(C(F)F)cc1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US06040309,CCOC(=O)c1sc2cc(Cn3ccnc3)ccc2c1Cl.COc1cccc(S)c1>>CCOC(=O)c1sc2cc(Cn3ccnc3)ccc2c1Sc1cccc(OC)c1,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US20120245136A1,CC(C)O[C@@H]1CC2(CCNCC2)Oc2ccc(F)cc21.O=C(O)c1ccc(Br)cn1>>CC(C)O[C@@H]1CC2(CCN(C(=O)c3ccc(Br)cn3)CC2)Oc2ccc(F)cc21,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100093724A1,COc1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(S(C)(=O)=O)n1>>CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(=O)[nH]1,,CC(=O)O,,Br,,val
US04814338,COc1cc(Cl)nc(S(C)(=O)=O)n1.O=CNc1ccccc1>>COc1cc(Cl)nc(Nc2ccccc2)n1,,C1CCOC1,O,Cl,,val
US05102905,CC(C)(C)C(=O)c1cccs1.CC(C)(CO)CO.c1ccccc1>>O=C(O)CSc1cccc2c1oc1ccccc12,,CCOCC,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150111870A1,CC(=O)OC(C)=O.COc1nc2ccc(C(O)(c3cnc(C)n3C)C3CN(C(=O)OC(C)(C)C)C3)cc2c(Cl)c1CN1CCC(C(F)(F)F)CC1>>COc1nc2ccc(C(O)(c3cnc(C)n3C)C3CN(C(C)=O)C3)cc2c(Cl)c1CN1CCC(C(F)(F)F)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080200460A1,CCNC1CCN(CC[C@@H](c2cc(F)cc(F)c2)C2CCN(S(C)(=O)=O)CC2)CC1.CS(=O)(=O)N1CCC(/C=C/C(=O)O)CC1>>CCN(C(=O)/C=C/C1CCN(S(C)(=O)=O)CC1)C1CCN(CC[C@@H](c2cc(F)cc(F)c2)C2CCN(S(C)(=O)=O)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160002175A1,Cc1c(F)ccc(B(O)O)c1C.Nc1nc(Cl)cc(NCCCN2CCCC2=O)n1>>Cc1c(F)ccc(-c2cc(NCCCN3CCCC3=O)nc(N)n2)c1C,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US06261738B1,COc1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COc1ccc(C(=O)C(F)(F)F)cc1,CN(C)c1ccncc1,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20050107391A1,COc1ccc(CNc2nc(Br)cnc2NC=O)cc1.OB(O)c1ccc(F)cc1>>COc1ccc(Cn2cnc3ncc(-c4ccc(F)cc4)nc32)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])O.[Na+],,val
US20040138063A1,CCCCCO.COC(=O)COc1ncccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl>>CCCCCOC(=O)COc1ncccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20150284405A1,CC1(C)OC[C@@H]2CCC(=O)N21.CCBr>>CCC1C[C@H]2COC(C)(C)N2C1=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20030212094A1,Nc1ccc(F)cc1.O=C(Cl)CCl>>O=C(CCl)Nc1ccc(F)cc1,,Cc1ccccc1,,O,,val
US20030191118A1,COc1cccc(OC)c1-c1ccc(C[C@H](NC(=O)c2c(Cl)cccc2Cl)C(=O)O)cc1.O=C(Cl)C(=O)Cl>>COc1cccc(OC)c1-c1ccc(C[C@H](NC(=O)c2c(Cl)cccc2Cl)C(=O)Cl)cc1,,C1CCOC1,,CN(C)C=O,,val
US20030092720A1,CC(C)c1csc(COc2ccn3c(=O)c(/C=C/C(=O)OC(C)(C)C)c(N4CCCC(O)C4)nc3c2)n1>>CC(C)c1csc(COc2ccn3c(=O)c(/C=C/C(=O)O)c(N4CCCC(O)C4)nc3c2)n1,,C1COCCO1,,Cl,,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)n3nc4cc(Cl)ccc4c3[nH]2)CC1.Cl>>Cl.O=c1cc(C2CCNCC2)n2nc3cc(Cl)ccc3c2[nH]1,,C1COCCO1,Cl,,,val
US04259336,CCOC(=O)CN(C)S(=O)(=O)c1c(C(=O)OC)sc2cc(C)ccc12>>COC(=O)C1=C(O)c2sc3cc(C)ccc3c2S(=O)(=O)N1C,,CO,,C[O-].[Na+],,val
US04002639,Fc1cccc(Cl)c1.O=c1[nH]nc2n1-c1ccccc1Oc1ccccc1-2>>O=c1n(-c2cccc(Cl)c2)nc2n1-c1ccccc1Oc1ccccc1-2,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US20090163709A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Oc1ccc2cccnc2c1>>CC(C)(C)OC(=O)Oc1ccc2cccnc2c1,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,,,val
US20080085890A1,CCNCC1CCN(c2ccc(N)cc2)CC1.CO/C=C1/C(=O)NC(=O)c2ccc(I)cc21>>CCNCC1CCN(c2ccc(N/C=C3\C(=O)NC(=O)c4ccc(I)cc43)cc2)CC1,,CN(C)C=O,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20100069355A1,CN(C)C=O.COc1c2[nH]c3ccc(F)cc3c2cc2c1[nH]c1ccc(F)cc12.CSC.N#CCCl>>COc1c2c(cc3c4cc(F)ccc4n(CCN)c13)c1cc(F)ccc1n2CCN,,C1CCOC1,,[H-].[Na+],,val
US20140275173A1,CC(C)(C)OC(=O)COCCC12CCC(c3cc(F)cc(OC4CCCCO4)c3)(CC1)OC2>>CC(C)(C)OC(=O)COCCC12CCC(c3cc(O)cc(F)c3)(CC1)OC2,,CO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20130023055A1,O=[N+]([O-])c1ccccc1OCCOc1cc(F)ccc1[N+](=O)[O-]>>Nc1ccccc1OCCOc1cc(F)ccc1N,[Pd],C1COCCO1,,CC(=O)O,,val
US20100029611A1,Nc1nc(Cl)ccc1Cl.S=C(Cl)Cl>>S=C=Nc1nc(Cl)ccc1Cl,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US20070026078A1,CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O.Cl.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O.Cl.O=C(O)C(O)C(O)C(=O)O,,C1COCCO1,,COC(C)(C)C,,val
US06699861B1,Cc1cc(C#N)c(N)cc1Cl.OO.[OH-]>>Cc1cc(C(=O)O)c(N)cc1Cl,,O,,Cl,,val
US20080188528A1,Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](N)C(=O)OC(C)(C)C)c(C)c2c1OC(C)(C)CC2.O=C(O)c1cccn(Cc2cccc(Cc3ccccc3)c2)c1=O>>Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)c2cccn(Cc3cccc(Cc4ccccc4)c3)c2=O)C(=O)OC(C)(C)C)c(C)c2c1OC(C)(C)CC2,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150266867A1,CC(C)(C)OC(=O)Nc1nc(/C(=N/OC2(C(=O)OC(c3ccccc3)c3ccccc3)CC2)C(=O)N[C@@H]2C(=O)N[C@@H]2CO)cs1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)Nc1nc(/C(=N/OC2(C(=O)OC(c3ccccc3)c3ccccc3)CC2)C(=O)N[C@@H]2C(=O)N[C@@H]2COS(C)(=O)=O)cs1,,C1CCOC1,CCOC(C)=O,,,val
US20070275900A1,CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O.O=S(Cl)Cl>>CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)Cl,,ClCCl,,,,val
US20150353489A1,CO.O=C(O)Cc1c[nH]c2ccc(O)cc12>>COC(=O)Cc1c[nH]c2ccc(O)cc12,,CO,,CC(=O)Cl,,val
US06432964B1,O=c1[nH]cnc2c(Br)sc(Br)c12>>O=c1[nH]cnc2c(Br)scc12,,CC(=O)O,,BrBr,,val
US20090318690A1,CCCOc1ccc2c(CCC3CCNCC3)noc2c1CN(C)C.O=Cc1ccccc1>>CCCOc1ccc2c(CCC3CCN(Cc4ccccc4)CC3)noc2c1CN(C)C,,CC(=O)O,ClCCl,O=C([O-])O.[Na+],,val
US20130309200A1,COc1ncc(Cl)cc1Nc1nc(N[C@@H](C)c2ccc(F)cn2)ccc1[N+](=O)[O-]>>COc1ncc(Cl)cc1Nc1nc(N[C@@H](C)c2ccc(F)cn2)ccc1N,[Ni],CCOC(C)=O,,,,val
US20100004239A1,CCN(CC)CCN1CCc2[nH]c(C=C3C(=O)Nc4ccc(F)cc43)c(C)c2C1=O.O=C(O)/C=C\C(=O)O>>CCN(CC)CCN1CCc2[nH]c(C=C3C(=O)Nc4ccc(F)cc43)c(C)c2C1=O.O=C(O)/C=C\C(=O)O,,CO,,ClCCl,,val
US20090018132A1,CC(O)c1cc(C(F)(F)F)cc2c(Br)n(COCC[Si](C)(C)C)nc12.N#CC(Cl)(Cl)Cl>>CC(OC(=N)C(Cl)(Cl)Cl)c1cc(C(F)(F)F)cc2c(Br)n(COCC[Si](C)(C)C)nc12,,CCOCC,,C1CCC2=NCCCN2CC1,,val
US20080113966A1,O=C(OCc1ccccc1)N1CCC(c2cc(-c3ccccc3)n[nH]c2=O)CC1>>O=c1[nH]nc(-c2ccccc2)cc1C1CCNCC1,[Pd],CCO,,,,val
US20040209948A1,CC(C)(C)OC(=O)N1CCC(N)CC1.O=S(=O)(Cl)c1ccc(F)c2c1CCCC2>>CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2ccc(F)c3c2CCCC3)CC1,,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20050222210A1,CC(=O)OC(C)=O.CNc1ccccc1CO>>CNc1ccccc1COC(C)=O,CN(C)c1ccncc1,C1CCOC1,,O,c1ccncc1,val
US04029787,CN1CCNCC1.N#Cc1ccc(Cl)c(S(N)(=O)=O)c1>>CN1CCN(c2ccc(C#N)cc2S(N)(=O)=O)CC1,,O,,CN(C)C=O,,val
US20070072865A1,O=C1OC(C2CCCCC2)(C2CCCCC2)C2CN(C(c3ccccc3)(c3ccccc3)c3ccccc3)CCN12>>O=C1OC(C2CCCCC2)(C2CCCCC2)C2CNCCN12,,C1CCOC1,,CCOC(C)=O,Cl,val
US20100041638A1,O=Cc1ccc(O)c(CN2CCOCC2)c1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>O=Cc1ccc(OS(=O)(=O)C(F)(F)F)c(CN2CCOCC2)c1,,ClCCl,,CCN(CC)CC,,val
US20060063759A1,C[Mg]Br.O=C1c2ccc(F)cc2CCc2ncccc21>>C=C1c2ccc(F)cc2CCc2ncccc21,,C1CCOC1,,[Cl-].[NH4+],,val
US20160229814A1,CCI.O=C1Nc2ccc([N+](=O)[O-])cc2OC1c1ccccc1>>CCN1C(=O)C(c2ccccc2)Oc2cc([N+](=O)[O-])ccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05831072,[N-]=[N+]=NC1O[C@H](COC(=O)c2ccccc2)[C@@H](OC(=O)c2ccccc2)[C@@H]1F>>NC1O[C@H](COC(=O)c2ccccc2)[C@@H](OC(=O)c2ccccc2)[C@@H]1F,[Pd],C1COCCO1,,[H][H],,val
US05180735,COC1C(O)CCC(O)(CSCc2ccccc2CO)C1C1(C)OC1CC=C(C)C.CS(=O)(=O)Cl>>COC1C(O)CCC(O)(CSCc2ccccc2COS(C)(=O)=O)C1C1(C)OC1CC=C(C)C,,ClCCl,,CCN(CC)CC,O,val
US05216167,CCCC(NC(=O)Cc1ccc(C=CC(=O)OCC)c(OCC)c1)c1ccccc1N1CCCCC1>>CCCC(NC(=O)Cc1ccc(C=CC(=O)O)c(OCC)c1)c1ccccc1N1CCCCC1,,CCO,,[Na+].[OH-],,val
US20090186879A1,COC(=O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(OC)nc1C>>COc1ccc(N2CCCn3c2nc2c(Cl)ccc(CO)c23)c(C)n1,,C1CCOC1,,[BH4-].[Li+],,val
US20040204450A1,CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(C(O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1CC.CI>>CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(C(OC)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1CC,,CS(C)=O,,[K+].[OH-],,val
US05019587,CC(=O)OC(C)=O.CC1(C)C(=O)Nc2cc(C(=O)Nc3ccc(N)cc3)ccc21>>CC(=O)Nc1ccc(NC(=O)c2ccc3c(c2)NC(=O)C3(C)C)cc1,,CC(=O)O,,,,val
US20100256092A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=Cc1ccc(Oc2cccnc2)cc1Br>>CC1(C)OB(c2cc(Oc3cccnc3)ccc2C=O)OC1(C)C,,C1COCCO1,,CC(=O)[O-].[K+],,val
US04402961,c1ccc(-c2cc(CCc3ccccn3)c3ccccc3n2)cc1>>c1ccc(-c2cc(CCC3CCCCN3)c3ccccc3n2)cc1,O=[Pt],CCO,,CC(=O)O,,val
US20100234340A1,COC(=O)c1ncn2c1CN(Cc1ccccc1)CC2>>COC(=O)c1ncn2c1CNCC2,,CO,,,,val
US20120172379A1,CCc1n[nH]c2ncnc(Cl)c12.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCc1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c2ncnc(Cl)c12,,CN(C)C=O,,[H-].[Na+],,val
US20090149452A1,N#Cc1cc(-c2nc3cncnc3s2)ccc1Cl.Sc1ccccc1>>N#Cc1cc(-c2nc3cncnc3s2)ccc1Sc1ccccc1,,CS(C)=O,,O,[H-].[Na+],val
US05248693,CC(=O)OC(C)=O.COc1cc(C(=O)NS(=O)(=O)c2ccccc2C#CC(C)(C)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12>>COc1cc(C(=O)NS(=O)(=O)c2ccccc2C#CC(C)(C)OC(C)=O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12,CN(C)c1ccncc1,CCOC(C)=O,c1ccncc1,,,val
US20040072816A1,CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C/c2ccccc2[N+](=O)[O-])c2ccc(C)cc2)cc1>>CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C/c2ccccc2N)c2ccc(C)cc2)cc1,[Pd],ClCCl,,,,val
US05670503,CC(=O)Oc1ccc(C(=O)N2CCn3nc(-c4ccc(F)cc4)c(-c4ccncc4)c3N2)cc1>>O=C(c1ccc(O)cc1)N1CCn2nc(-c3ccc(F)cc3)c(-c3ccncc3)c2N1,,CO,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20150094328A1,CC(C)(C)OC(=O)n1cc(C(=O)N[C@H]2CCCC[C@@H]2O)c2nc(C#N)ccc21.Cc1cc(CBr)ccc1F>>Cc1cc(Cn2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c3ncccc32)ccc1F,,CO,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20040186160A1,O=C1Cc2c(cccc2-c2cccc(F)c2)N1.O=Cc1[nH]c2c(c1CCCO)CCCCC2>>O=C1Nc2cccc(-c3cccc(F)c3)c2/C1=C/c1[nH]c2c(c1CCCO)CCCCC2,,CCO,,C1CCNCC1,,val
US20150119385A1,CC(=O)Cl.COC(OC)c1nc2c(cc1CNCCN(C)C)CCCN2>>COC(OC)c1nc2c(cc1CN(CCN(C)C)C(C)=O)CCCN2,,ClCCl,,CCN(CC)CC,,val
US20060084802A1,BrBr.COC(=O)c1ccnc(N)c1>>COC(=O)c1cc(N)ncc1Br,,ClC(Cl)Cl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20140364432A1,Cc1nc(C(=O)N2CCC[C@@H](C)[C@@H]2CNC(=O)OC(C)(C)C)c(-c2ccc(F)cc2)s1>>Cc1nc(C(=O)N2CCC[C@H](C)[C@H]2CN)c(-c2ccc(F)cc2)s1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130345194A1,CC(C)(C)OC(=O)n1ccc2c(N3CCN(S(N)(=O)=O)C4(CC4)C3)ncnc21.CN(C)C=O.N#CCCCBr.O=C([O-])[O-]>>CC(C)(C)OC(=O)n1ccc2c(N3CCN(S(=O)(=O)N(CCCC#N)CCCC#N)C4(CC4)C3)ncnc21,,CN(C)C=O,,O,,val
US20100075948A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.Nc1ccc2c(c1)C(=O)NC2=O>>CC(C)(C)CC1NC(C(=O)Nc2ccc3c(c2)C(=O)NC3=O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F,,CCN(CC)CC,,O=S(Cl)Cl,,val
US20100168062A1,CC1(C)OB(c2cn[nH]c2)OC1(C)C.ClCCCN1CCOCC1>>CC1(C)OB(c2cnn(CCCN3CCOCC3)c2)OC1(C)C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060111347A1,CC1(C)COC(=O)[C@@H]1O.Sc1ccc2ccccc2c1>>CC(C)(CSc1ccc2ccccc2c1)[C@@H](O)C(=O)O,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20030095958A1,CC(C)(C)[SiH2]OC(c1ccccc1)(c1ccccc1)C1CN(Cc2ccccc2)CCC1=O.Cl[Mg]c1ccc(-c2ccccc2)cc1>>CC(C)(C)[SiH2]OC(c1ccccc1)(c1ccccc1)C1CN(Cc2ccccc2)CCC1(O)c1ccc(-c2ccccc2)cc1,,C1CCOC1,CCOCC,,,val
US05401772,COc1ccc(Oc2c(Cl)cc([N+](=O)[O-])cc2Cl)cc1C(C)C>>COc1ccc(Oc2c(Cl)cc(N)cc2Cl)cc1C(C)C,[Pt],CCO,,,,val
US05102877,O=C(Cl)OCc1ccc([N+](=O)[O-])cc1.O=C(O)[C@@H]1CSCN1>>O=C(O)[C@@H]1CSCN1C(=O)OCc1ccc([N+](=O)[O-])cc1,,C1CCOC1,O,Cl,[Na+].[OH-],val
US05677439,CC(C)(C)[Si](C)(C)Cl.Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O.[I-]>>Cc1cn([C@H]2C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](CI)O2)c(=O)[nH]c1=O,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20130109677A1,O=C(O)CC(C[N+](=O)[O-])c1ccsc1>>O=C1CC(C[N+](=O)[O-])c2ccsc21,,ClCCCl,,,,val
US20050165042A1,BrBr.CCc1nccnc1C(C)=O>>CCc1nccnc1C(=O)CBr,,ClC(Cl)Cl,,,,val
US20020040043A1,N#Cc1ccc(CCOc2cccc(N)c2)cc1.O=S(=O)(Cl)c1ccccc1>>N#Cc1ccc(CCOc2cccc(NS(=O)(=O)c3ccccc3)c2)cc1,,c1ccncc1,,Cl,O,val
US20160244444A1,N.OC1(c2ccc(Cl)nc2F)CCC1>>Nc1ccc(C2(O)CCC2)c(F)n1,O=[Cu],CN1CCCC1=O,,O,,val
US20050130221A1,COc1ccc(C#CCCSCc2ccccc2)cc1OC(C)=O.II>>COc1ccc(C2=C(I)CCS2)cc1OC(C)=O,,CCOCC,ClCCl,,,val
US20070072925A1,O=C[C@H](F)c1cccc(Br)c1>>OC[C@H](F)c1cccc(Br)c1,,CCO,ClCCl,[BH4-].[Na+],[Cl-].[NH4+],val
US05910506,CC(C)c1nc(COCc2ccccc2)[nH]c1Sc1cccc(Cl)c1.CI>>CC(C)c1c(Sc2cccc(Cl)c2)nc(COCc2ccccc2)n1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100035863A1,CC1CC=C(B(O)O)CC1.Nc1nc(Cl)cc(Cl)n1>>CC1CC=C(c2cc(Cl)nc(N)n2)CC1,,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US05432169,CC1=CC(C)(C(N)=[NH2+])N=N1.C[C@]12CC[C@H](OCCN)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccoc3)CC[C@]12O.O=[N+]([O-])[O-]>>C[C@]12CC[C@H](OCCNC(=N)N)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccoc3)CC[C@]12O[N+](=O)[O-],,CCO,,,,val
US04988723,CCC1(CC)Oc2ccc(C#N)cc2C2OC21.N#CN=C1NCCS1>>CCC1(CC)Oc2ccc(C#N)cc2[C@@H](N2CCSC2=NC#N)[C@@H]1O,,CCN(CC)CC,CN(C)C=O,O,,val
US04271163,CC(=O)Cl.Nc1cccc(C2=NNC(=O)C3CC23)c1>>CC(=O)Nc1cccc(C2=NNC(=O)C3CC23)c1,,Cc1ccccc1,,,,val
US04861785,CCOC(=O)N1CCC(N)CC1.CS(=O)(=O)c1nc2cnccc2s1>>CCOC(=O)N1CCC(Nc2nc3cnccc3s2)CC1,,ClC(Cl)Cl,,,,val
US20090118244A1,COc1ccc(CN2C(=O)CN=C(c3ccc(F)cc3)c3cc(Cl)ccc32)cc1.Cc1ccccc1CBr>>COc1ccc(CN2C(=O)C(Cc3ccccc3C)N=C(c3ccc(F)cc3)c3cc(Cl)ccc32)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20040260088A1,CCSc1c(CN(C)C)cccc1Oc1cc(Cl)ccc1C#N.CO.O=C(O)/C=C/C(=O)O>>CCS(=O)c1c(CN(C)C)cccc1Oc1cc(Cl)ccc1C#N.O=C(O)/C=C/C(=O)O,,CO,,,,val
US20070259951A1,CC1(C)OB(c2ccc(NS(C)(=O)=O)c(F)c2)OC1(C)C.Fc1c(Br)ccc(C(F)(F)F)c1F>>CS(=O)(=O)Nc1ccc(-c2ccc(C(F)(F)F)c(F)c2F)cc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150291514A1,CC(C)Oc1ncc(Oc2cc(F)c(C(=O)O)cc2F)cc1Cl.COc1ccc(CN(C)S(N)(=O)=O)cc1>>COc1ccc(CN(C)S(=O)(=O)NC(=O)c2cc(F)c(Oc3cnc(OC(C)C)c(Cl)c3)cc2F)cc1,CN(C)c1ccncc1,Cl,ClCCl,CCN(C(C)C)C(C)C,CCN=C=NCCCN(C)C,val
US04684661,C#CCCN(C)Cc1cccc2ccccc12.CCC(=O)CC>>CCC(O)(C#CCCN(C)Cc1cccc2ccccc12)CC,,CCCCCC,,C1CCOC1,[Li]CCCC,val
US20070197597A1,Cl.NO.O=Cc1cccc(-c2ccncc2)c1>>Cl.ON=Cc1cccc(-c2ccncc2)c1,,CO,,,,val
US20150361101A1,CI.CNC(=O)c1c(I)oc2cc(NS(C)(=O)=O)c(Br)cc12>>CNC(=O)c1c(I)oc2cc(N(C)S(C)(=O)=O)c(Br)cc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05155122,CC(C)(C)c1cc(C=CC(=O)NN)cc(C(C)(C)C)c1O.S=C=S>>CC(C)(C)c1cc(C=Cc2n[nH]c(=S)o2)cc(C(C)(C)C)c1O,,CCO,,[K+].[OH-],,val
US04791103,Cl.NCC1(O)CCc2ccccc21>>Cl.NCC1=CCc2ccccc21,,CCO,,,,val
US20030036557A1,Br.C=C(Cl)COc1ccc(Cl)cc1.CC#N.CCOCC.O=C1CCC(=O)N1Br>>O=C(CBr)Cc1ccccc1Oc1ccc(Cl)cc1,,CCOCC,,O,,val
US20110288076A1,O=C(N[C@@H]1C[C@@H](C(=O)Nc2ccc(Oc3ccc(F)cc3)cc2)N(C(=O)Cc2cnc[nH]2)C1)OCc1ccccc1>>N[C@@H]1C[C@@H](C(=O)Nc2ccc(Oc3ccc(F)cc3)cc2)N(C(=O)Cc2cnc[nH]2)C1,[Pd],CO,,,,val
US20110105514A1,CCc1ncn2c1C(CCc1ccc(C(F)(F)F)c(F)c1)N(C(=O)OC(C)(C)C)CC2.O=C1CCC(=O)N1Br>>CCc1nc(Br)n2c1C(CCc1ccc(C(F)(F)F)c(F)c1)N(C(=O)OC(C)(C)C)CC2,,CCCCCCC,CCOC(C)=O,,,val
US05739132,CCCCS(=O)(=O)Cl.NC1Cc2ccc(C3=NNC(=O)CC3)cc2C1>>CCCCS(=O)(=O)NC1Cc2ccc(C3=NNC(=O)CC3)cc2C1,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US05160365,CC(C)OC(=O)c1ccc(Cl)cc1S(=O)(=O)N=C=O.COc1nc(N)nc(C(F)(F)F)n1>>COc1nc(NC(=O)NS(=O)(=O)c2cc(Cl)ccc2C(=O)OC(C)C)nc(C(F)(F)F)n1,,ClCCCl,,,,val
US20110071126A1,C[Si](C)(C)N=C=N[Si](C)(C)C.N#Cc1cccc(-c2ccc3c(c2)C(=O)C2(CCOCC2)C3)c1>>N#CN=C1c2cc(-c3cccc(C#N)c3)ccc2CC12CCOCC2,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20030036618A1,CO.O=[N+]([O-])c1c(F)c(F)c(F)c(F)c1F>>COc1c(F)c(F)c([N+](=O)[O-])c(F)c1F,,CO,,C[O-].[Na+],,val
US20140031563A1,CCOC(=O)C(=O)OCC.O=C(Cc1ccccc1)Nc1ccccc1>>O=C1C(O)=C(c2ccccc2)C(=O)N1c1ccccc1,,O,,CC(C)(C)[O-].[K+],,val
US20100048636A1,CC(C)(C)[Si](C)(C)Cl.O[C@@H]1CCCC[C@H]1Br>>CC(C)(C)[Si](C)(C)O[C@@H]1CCCC[C@H]1Br,,CN(C)C=O,,O,c1c[nH]cn1,val
US20110144105A1,COc1cccc(B(O)O)c1.Cc1ccc(S(=O)(=O)OC(=CC(C)C)c2cc3cccnc3n2S(=O)(=O)c2ccccc2)cc1>>COc1cccc(C(=CC(C)C)c2cc3cccnc3n2S(=O)(=O)c2ccccc2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US04634705,C=CCc1cccc2c1NCC2.CCOC(=O)Cl>>C=CCc1cccc2c1N(C(=O)OCC)CC2,,c1ccncc1,,,,val
US05968955,COc1cc(C(O)CBr)on1.O=C(c1ccc(F)cc1)C1CCNCC1>>COc1cc(C(O)CN2CCC(C(=O)c3ccc(F)cc3)CC2)on1,,CCO,,CCN(C(C)C)C(C)C,,val
US20030130328A1,CC#N.CCOC(=O)c1ccc(N(C)C)cc1>>CN(C)c1ccc(C(=O)CC#N)cc1,,C1CCOC1,CCOC(C)=O,[Li]CCCC,,val
US20150175594A1,Cc1csc(-c2c(N)sc3c2CCC3)n1.O=C1OC(=O)C2=C1CCC2>>Cc1csc(-c2c(NC(=O)C3=C(C(=O)O)CCC3)sc3c2CCC3)n1,CN(C)c1ccncc1,CCOCC,,,,val
US20070167443A1,CON(C)C(=O)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O.Cc1cc(C)cc([Mg]Br)c1>>Cc1cc(C)cc(C(=O)c2cn(Cc3cccc(Br)n3)c3ccccc3c2=O)c1,,C1CCOC1,,,,val
US20110245310A1,CCOC(=O)C(C(=O)OCC)(C(=O)OCC)C1CCc2nc(C(C)C)n(Cc3ccc(Cl)cc3)c21>>CC(C)c1nc2c(n1Cc1ccc(Cl)cc1)C(CC(=O)O)CC2,,CCO,,[Na+].[OH-],,val
US20070112070A1,BrCC1CC1.COC(=O)[C@@H](O)Cc1ccc(Br)cc1>>COC(=O)[C@H](Cc1ccc(Br)cc1)OCC1CC1,O=[Ag],CCOCC,,,,val
US20050026990A1,CCCCOc1ccc(S(=O)(=O)N[C@H]2CC(=O)N(OCc3ccccc3)C2=O)cc1>>CCCCOc1ccc(S(=O)(=O)N[C@H]2CC(=O)N(O)C2=O)cc1,[Pd],CCOC(C)=O,CO,,,val
US20050070441A1,Cc1cc(Oc2ncc(C(F)(F)F)cc2Cl)n[nH]1.S=C=NCCBr>>C=CNC(=S)n1nc(Oc2ncc(C(F)(F)F)cc2Cl)cc1C,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130052151A1,C=CCCCCCCCCCC(=O)CC(C)CCC=C(C)C>>CC1CCC=CCCCCCCCCCC(=O)C1,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,ClCCl,,,,val
US20120101127A1,CC(C)(N)C(=O)O.CC1(C)CC(c2cccc(Br)c2)Nc2ccc(Cl)cc21>>CC(C)(Nc1cccc(C2CC(C)(C)c3cc(Cl)ccc3N2)c1)C(=O)O,[Cu]I,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06211215B1,Br.C=CC(=O)OC.COc1ccc(N)cn1>>COC(=O)C(Br)Cc1ccc(OC)nc1,,CC(C)=O,O,O=N[O-].[Na+],,val
US20060235031A1,N.OCC1CC(c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(Cl)nccn23)C1>>Nc1nccn2c(C3CC(CO)C3)nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c12,,CC(C)O,,,,val
US20120077847A1,CC(Br)CCCCO.Oc1cccc(F)c1>>OCCCCCCOc1cccc(F)c1,,CCOCC,O,[Na+].[OH-],,val
US20120040984A1,CCOC(=O)CC1CCC(c2ccc(O)cc2)CC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)CC1CCC(c2ccc(OS(=O)(=O)C(F)(F)F)cc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080275043A1,CC(C)(C)[Si](C)(C)O[C@H]1CC[C@@H](N2CCC(Cc3c(Cl)cc(OS(=O)(=O)C(F)(F)F)cc3Cl)C2=O)CC1.OB(O)c1ccncc1>>CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@H](N2CCC(Cc3c(Cl)cc(-c4ccncc4)cc3Cl)C2=O)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20100137347A1,CCCCC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(C2=CCC[C@@H]2CCCc2cccs2)cc1.CN(C)C=O>>CCCCC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(C2=CCC[C@@H]2CCCc2ccc(C=O)s2)cc1,,CCOCC,,[Li]CCCC,,val
US20120165316A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.COC(=O)c1ccc2c(c1)CCN(Cc1ccc(Br)cc1)C2>>COC(=O)c1ccc2c(c1)CCN(Cc1ccc(C3=CCN(C(=O)OC(C)(C)C)CC3)cc1)C2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20160039822A1,COC(=O)CC[C@H](C)n1c(Nc2c(F)cc(F)cc2F)nc2cnc(NC(C)C)nc21.N>>CC(C)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@@H](C)CCC(N)=O)c2n1,,CO,,,,val
US20090291903A1,CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)N1CCCN(C2CCC2)CC1.Oc1cccc(F)c1>>CC(C)(C)OC(=O)N1CC(Oc2cccc(F)c2)C[C@H]1C(=O)N1CCCN(C2CCC2)CC1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150344494A1,COC(=O)c1ccc(B(O)O)cc1.O=c1cc(N2CCOCC2)oc2c(Br)csc12>>COC(=O)c1ccc(-c2csc3c(=O)cc(N4CCOCC4)oc23)cc1,,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06288061B1,CC(=O)NCc1ccc(CN2CCOCC2)cc1>>NCc1ccc(CN2CCOCC2)cc1,,Cl,,,,val
US04016170,COC(=O)c1ccccc1C(=O)Cl.NC(=NO)c1ccccc1>>COC(=O)c1ccccc1-c1nc(-c2ccccc2)no1,,C1COCCO1,,CCOCC,FB(F)F,val
US05312823,CCOC(=O)Cl.NCc1ncccn1>>CCOC(=O)NCc1ncccn1,,Cc1ccccc1,,CCN(CC)CC,,val
US20060258721A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNC1CC=C(c2c[nH]c3ccc([N+](=O)[O-])cc23)CC1>>CN(C(=O)OC(C)(C)C)C1CC=C(c2c[nH]c3ccc([N+](=O)[O-])cc23)CC1,,C1COCCO1,,CCN(CC)CC,,val
US20140148412A1,C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@@]43C)[C@@H]1CC[C@@H]2CO>>C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@@]43C)[C@@H]1CC[C@@H]2C=O,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20110195954A1,CCOC(=O)c1cc(Cl)ncn1.OC1Nc2ccccc2C=C1C1CCNCC1>>CCOC(=O)c1cc(N2CCC(c3cc4ccccc4[nH]c3=O)CC2)ncn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20090142297A1,NCc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1ccc2ccccc2n1>>O=C1CCC(N2C(=O)c3ccc(CNC(=O)c4ccc5ccccc5n4)cc3C2=O)C(=O)N1,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20060116515A1,CN(CCNCCc1ccc2c(c1)OCO2)c1nc(-n2ccnc2)ns1.CO>>CN(CCc1ccc2c(c1)OCO2)CCN(C)c1nc(-n2ccnc2)ns1,,CO,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20070082912A1,CCOC(=O)c1cncc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2)c1>>Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2)n1-c1cncc(C(=O)O)c1,,CCOC(C)=O,,CCO,,val
US20150329538A1,Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1F.N[C@H]1CC[C@H]1N>>Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H]1CC[C@@H]1N,,CS(C)=O,,,,val
US05688803,CCOC(=O)c1c(-c2cc(Cl)c(Cl)cc2N)[nH][nH]c1=O>>O=c1[nH][nH]c2c1c(O)nc1cc(Cl)c(Cl)cc12,,CN(C)C=O,,CCO,,val
US20090306202A1,C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](OC(=O)C(F)(F)F)C[C@]2(C)[C@@]1(O)C(=O)CO,CN(C)c1ccncc1,C1CCOC1,O,,,val
US20080009512A1,CC(C)(C)OC(=O)N[C@@H](CC(=O)ON1C(=O)CCC1=O)Cc1ccccc1F.NC1Cc2ccccc2NC1=O>>CC(C)(C)OC(=O)N[C@@H](CC(=O)NC1Cc2ccccc2NC1=O)Cc1ccccc1F,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US04824959,CC=CC=CC=O.COC(=O)CC(C)=O>>CC=CC=CC(=O)CC(O)CC(=O)OC,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US05776718,O=[N+]([O-])c1ccc(CCl)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=[N+]([O-])c1ccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1.[Cl-],,CC#N,CCOCC,,,val
US06329389B1,CCOC(=O)CP(=O)(OCC)OCC.COc1ccc(Oc2ccc(C=O)cc2)cc1>>COc1ccc(Oc2ccc(/C=C/C(=O)O)cc2)cc1,,CCO,O,[Na+].[OH-],,val
US04711883,COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccc(OC)c(OC)c3c2=O)CC1>>COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccc(O)c(O)c3c2=O)CC1,,Br,CC(=O)O,,,val
US20100179126A1,C=Cc1ccc2c(c1)NC(=O)CCC2=O>>CCc1ccc2c(c1)NC(=O)CCC2=O,[Pd],CCO,,,,val
US20090181942A1,CCOC(=O)C[C@H]1S[C@H](c2cccc(F)c2F)c2cc(Cl)ccc2NC1=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)C[C@H]1S[C@H](c2cccc(F)c2F)c2cc(Cl)ccc2NC1=S,,Cc1ccccc1,,,,val
US20080070928A1,COc1ccccc1Oc1cc(F)cc(N)c1[N+](=O)[O-].Oc1cccnc1>>COc1ccccc1Oc1cc(Oc2cccnc2)cc(N)c1[N+](=O)[O-],,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100048610A1,CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1O.O=Cc1cc(F)ccc1[N+](=O)[O-]>>CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1Oc1ccc([N+](=O)[O-])c(C=O)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130203593A1,NN.O=Cc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1>>N/N=C/c1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1,,CCO,O,,,val
US20130116234A1,CC(C)(C)OC(=O)c1c(O)nc2ccc(Cl)cc2c1-c1cccc(Cl)c1.CC(C)Br>>CC(C)Oc1nc2ccc(Cl)cc2c(-c2cccc(Cl)c2)c1C(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20140364411A1,Nc1cccc(O)c1.O=N[O-]>>NNc1cccc(O)c1,,Cl,O,Cl[Sn]Cl,,val
US20050153979A1,CCc1cc2cc(F)ccc2n1C1CCN(Cc2ccccc2)CC1.Fc1ccc(SCCCBr)cc1>>CCc1cc2cc(F)ccc2n1C1CCN(CCCSc2ccc(F)cc2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100022598A1,CN(C)S(=O)(=O)n1cnc(CC(C)(C)C)c1.CON(C)C(=O)C(F)(F)c1ccc(-c2ccc(F)cn2)cc1>>CN(C)S(=O)(=O)n1cc(CC(C)(C)C)nc1C(=O)C(F)(F)c1ccc(-c2ccc(F)cn2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20120245094A1,C=CCOC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)OC)C(C)C)C(C)C>>C=CCOC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)C(C)C,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US05057517,CCc1nc(Cl)c([N+](=O)[O-])c(Cl)n1>>CCc1nc(Cl)c(N)c(Cl)n1,[Ni],CO,,CCOC(C)=O,,val
US20050043537A1,CCOC(OCC)OCC.CCOc1ccc(N)cc1F.COc1cc(NC(=O)CC#N)c(Cl)cc1Cl>>CCOc1ccc(NC=C(C#N)C(=O)Nc2cc(OC)c(Cl)cc2Cl)cc1F,,CC(C)O,,,,val
US20110294189A1,CC(C)(Br)C(=O)O.CC(C)(C)OC(=O)NOCCO>>CC(C)(C)OC(=O)NOCCOC(=O)C(C)(C)Br,,ClCCl,,CCN(CC)CC,,val
US20070293515A1,CC(C)(C)OC(=O)N[C@H]1CC[C@@H](C(=O)O/N=C(\N)c2ccccc2)C1>>CC(C)(C)OC(=O)N[C@H]1CC[C@@H](c2nc(-c3ccccc3)no2)C1,,CCO,O,CC(=O)[O-].[Na+],,val
US20020006948A1,CN=C=O.OCCCCOc1ccc2nc(-c3ccccc3)n(-c3ccccc3)c2c1>>CNC(=O)OCCCCOc1ccc2nc(-c3ccccc3)n(-c3ccccc3)c2c1,,ClCCl,,CCN(CC)CC,,val
US04062862,FC=CCc1ccccc1.O=C(OO)c1ccccc1>>FC=CCC1=CC2OC2C=C1,,ClC(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20110207783A1,CCOC(=O)C(CNC(=O)OC(C)(C)C)Cc1cccnc1Cl>>CCOC(=O)C(CNC(=O)OC(C)(C)C)Cc1cccnc1,[Pd],CO,,CC(=O)[O-].[Na+],,val
US20100016282A1,CC(C)(C)OC(=O)N1CCC(=O)N(OCc2ccccc2)C[C@H]1Cc1ccccc1>>CC(C)(C)OC(=O)N1CCC(=O)NC[C@H]1Cc1ccccc1,,CO,,,,val
US20040254217A1,NC(=O)C=Cc1cccc(C(F)(F)F)c1.O=C(CCl)CCl>>FC(F)(F)c1cccc(C=Cc2nc(CCl)co2)c1,,Cc1ccccc1,,,,val
US20050124605A1,Cc1cc(C)nc(S(C)(=O)=O)n1.O=C1CN2C(=O)[C@@H](O)[C@]2(c2ccccc2)c2ccccc2N1c1ccccc1>>Cc1cc(C)nc(O[C@@H]2C(=O)N3CC(=O)N(c4ccccc4)c4ccccc4[C@@]23c2ccccc2)n1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US05753664,Cc1c(O)nc2scc(C)n2c1=O.O=C(c1ccc(CBr)cc1)c1ccc([N+](=O)[O-])cc1>>Cc1c(OCc2ccc(C(=O)c3ccc([N+](=O)[O-])cc3)cc2)nc2scc(C)n2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100234389A1,CC(C)(C)OC(=O)N1CCN(c2cc(Cl)ncn2)CC1.OB(O)c1ccc(F)cc1F>>CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccc(F)cc3F)ncn2)CC1,,O,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US05206235,CC(C)(C)OC(=O)NCC(=O)NC1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C1=O.Cl>>Cl.NCC(=O)NC1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C1=O,,CO,,,,val
US04210648,CCNCC.CN1C(=O)c2ccccc2N(C(=O)CCCCl)c2ncccc21>>CCN(CC)CCCC(=O)N1c2ccccc2C(=O)N(C)c2cccnc21.Cl,,CN(C)C=O,,,,val
US20160068512A1,OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc2ncnc(Nc3ccc(C(F)(F)F)cc3)c2c1>>FC(F)(F)c1ccc(Nc2ncnc3ccc(C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)cc23)cc1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20080051395A1,CN(C)C1Cc2ccc(Nc3nccc(-c4c(-c5ccc(F)c(N)c5)nn5ccccc45)n3)cc2C1.O=C(Cl)c1c(F)cccc1F>>CN(C)C1Cc2ccc(Nc3nccc(-c4c(-c5ccc(F)c(NC(=O)c6c(F)cccc6F)c5)nn5ccccc45)n3)cc2C1,,C1CCOC1,ClCCl,,,val
US20160159804A1,CC(C)(C)OC(=O)N1CCC(n2ncc3ncnc(Oc4ccc(Oc5ccccc5)cc4)c32)CC1.Cl>>Cl.c1ccc(Oc2ccc(Oc3ncnc4cnn(C5CCNCC5)c34)cc2)cc1,,CO,,,,val
US20060264460A1,N#Cc1cnc2c(Cl)cc(N)cc2c1Nc1ccc(F)c(Cl)c1.O=Cc1cccc(N2CCOCC2)n1>>N#Cc1cnc2c(Cl)cc(NCc3cccc(N4CCOCC4)n3)cc2c1Nc1ccc(F)c(Cl)c1,,CCO,,[BH3-]C#N.[Na+],,val
US20040198693A1,BrCc1ccccc1.OCc1cc(C(F)(F)F)ccc1O>>OCc1cc(C(F)(F)F)ccc1OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US06713471B1,CCOC(=O)OCC.Fc1cccc(S)c1>>CSc1cccc(F)c1,C1COCCOCCOCCOCCOCCO1,,,O=C([O-])[O-].[K+].[K+],,val
US20110294788A1,COC(C)(C)OC.O=S(=O)(c1ccc(Cl)nc1)N(CC(O)CO)c1ccccc1>>CC1(C)OCC(CN(c2ccccc2)S(=O)(=O)c2ccc(Cl)nc2)O1,,CCOC(C)=O,CN(C)C=O,Cc1ccc(S(=O)(=O)O)cc1,,val
US06316436B1,CCC1(c2cccc(OC)c2)CCCCNC1>>CCC1(c2cccc(O)c2)CCCCNC1,,ClCCl,,BrB(Br)Br,,val
US20110166132A1,CC1(C)OB(c2cnn(C3CC3)c2)OC1(C)C.Cc1cc(-c2ccc(NC(=O)C(C)c3cc(Cl)cc(Br)c3)cc2)ccn1>>Cc1cc(-c2ccc(NC(=O)C(C)c3cc(Cl)cc(-c4cnn(C5CC5)c4)c3)cc2)ccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20090209532A1,COc1cc2sc(C(=O)N3CCOCC3)c(CBr)c2cc1OC>>O=C(c1sc2cc(O)c(O)cc2c1CBr)N1CCOCC1,,ClCCl,,BrB(Br)Br,CO,val
US20050107377A1,COc1cccc(-c2noc3ncccc23)c1>>Oc1cccc(-c2noc3ncccc23)c1,,ClCCCl,,BrB(Br)Br,,val
US20110052534A1,CCCOc1ccc(-c2ncc(C(Br)C(=O)OC)cn2)c(C(F)(F)F)c1.Fc1cccc(-c2nc3cn[nH]cc-3n2)c1F>>CCCOc1ccc(-c2ncc(C(C(=O)OC)n3cc4nc(-c5cccc(F)c5F)nc-4cn3)cn2)c(C(F)(F)F)c1,,CCOC(C)=O,CN(C)C=O,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US20100105740A1,COc1cc(CNC(C)=O)c(Br)cc1OC(C)=O.Cl>>COc1cc(CNC(C)=O)c(Cl)cc1O,,C1COCCO1,,[Na+].[OH-],,val
US20130267510A1,CC1CCOc2cccc(Oc3ncc([N+](=O)[O-])cn3)c21>>CC1CCOc2cccc(Oc3ncc(N)cn3)c21,[Fe],C1CCOC1,O,[Cl-].[NH4+],,val
US20040152698A1,COc1cc[n+]([O-])cc1C>>COc1ccncc1C,[Pd],CO,,,,val
US20090227583A1,Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1.O=C(Cl)Cc1cccs1>>O=C(Cc1cccs1)Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1,,Cc1ccccc1,O,CCN(CC)CC,,val
US05885986,C=CCNCC=C.CN1Cc2c(-c3nc(CCl)cs3)ncn2-c2ccc(F)cc2C1=O>>C=CCN(CC=C)Cc1csc(-c2ncn3c2CN(C)C(=O)c2cc(F)ccc2-3)n1,,C1CCOC1,,,,val
US20060217372A1,COc1cc(C=O)ccc1Oc1ccc(C(N)=O)nn1.NCCC1CCOCC1>>COc1cc(CNCCC2CCOCC2)ccc1Oc1ccc(C(N)=O)nn1,,CO,,[BH4-].[Na+],,val
US20160159774A1,O=[N+]([O-])c1ccc2c(c1)CN(CC(F)(F)F)C2>>Nc1ccc2c(c1)CN(CC(F)(F)F)C2,[Pd],CO,,,,val
US20050059702A1,CC(C)(C)OC(=O)N1CC(CN)C1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>O=[N+]([O-])c1ccccc1S(=O)(=O)N1CC(CO)C1,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20160159774A1,CC(=O)Cl.O=[N+]([O-])c1ccc2c(c1)CNCC2>>CC(=O)N1CCc2ccc([N+](=O)[O-])cc2C1,,C1CCOC1,O,CCN(CC)CC,,val
US09309263B2,CC(C)(C)OC(=O)NC1=N[C@]2(C)c3cc([N+](=O)[O-])ccc3OCC[C@H]2S(=O)(=O)C1(C)C.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)C1=N[C@]2(C)c3cc([N+](=O)[O-])ccc3OCC[C@H]2S(=O)(=O)C1(C)C,CN(C)c1ccncc1,CCOC(C)=O,,CCN(CC)CC,ClCCl,val
US06469003B1,CC(=O)c1nn(-c2ccc(F)cc2)c(=O)c(Br)c1C.OCCO>>Cc1c(C2(C)OCCO2)nn(-c2ccc(F)cc2)c(=O)c1Br,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20110046133A1,COC(=O)c1cc2[nH]c(-c3c(Cl)cccc3Cl)nc2c(F)c1F>>O=C(O)c1cc2[nH]c(-c3c(Cl)cccc3Cl)nc2c(F)c1F,,CO,,Cl,[Na+].[OH-],val
US20130123235A1,COC(=O)c1c(CS(=O)(=O)c2ccccc2)ccc(-c2ccoc2C(C)O)c1O>>COC(=O)c1c(CS(=O)(=O)c2ccccc2)ccc2c1OC(C)c1occc1-2,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05649537,CC(C)(C)OC(=O)C(Br)COCc1ccc([N+](=O)[O-])cc1.NCCNCCN>>CC(C)(C)OC(=O)C(COCc1ccc([N+](=O)[O-])cc1)NCCNCCN,,CC#N,,,,val
US20130059834A1,Fc1cc(F)c2cn[nH]c2c1.II>>Fc1cc(F)c2c(I)n[nH]c2c1,,CN(C)C=O,,[K+].[OH-],,val
US20160060265A1,O=C(c1cnn(C2CCCCO2)c1)N(CC(F)(F)F)c1cc(Cl)cnc1Cl>>O=c1c2cnn(C3CCCCO3)c2c2ncc(Cl)cc2n1CC(F)(F)F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,CC(=O)[O-].[K+],,val
US20060052609A1,CN([C@@H](CCC(N)=O)C(=O)O)N1Cc2c(cccc2[N+](=O)[O-])C1=O>>CN([C@@H](CCC(N)=O)C(=O)O)N1Cc2c(N)cccc2C1=O,[Pd],CO,,,,val
US20080058401A1,CC(C)(C)CCc1cc(C(F)(F)F)ccc1CN.COC(=O)n1ncc2c(NC(=O)ON3C(=O)CCC3=O)cccc21>>CC(C)(C)CCc1cc(C(F)(F)F)ccc1CNC(=O)Nc1cccc2[nH]ncc12,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US03954732,Cn1nnnc1SCC1(C)S[C@@H]2C(NC(=O)Cn3cnnn3)C(=O)N2C1C(=O)OCC(Cl)(Cl)Cl>>Cn1nnnc1SCC1(C)S[C@@H]2C(NC(=O)Cn3cnnn3)C(=O)N2C1C(=O)O,[Zn],CN(C)C=O,,CC(=O)O,,val
US20160016927A1,Nc1cccc(-c2ccc3c(c2)CC(c2cccc(C(F)(F)F)c2)(C(F)(F)F)O3)c1.O=C(Cl)C1CC1>>O=C(Nc1cccc(-c2ccc3c(c2)CC(c2cccc(C(F)(F)F)c2)(C(F)(F)F)O3)c1)C1CC1,,C1CCOC1,,CCN(CC)CC,O,val
US20150299121A1,CCOC(=O)C1C2CCCC21>>O=C(O)C1C2CCCC21,,CO,O,[Na+].[OH-],,val
US20160009718A1,Cc1cc(C)c(CN)c(=O)[nH]1.Cc1ccc2c(C(=O)O)c(C)c(C(C)C3CCN(CC(C)(C)O)CC3)n2n1>>Cc1ccc2c(C(=O)NCc3c(C)cc(C)[nH]c3=O)c(C)c(C(C)C3CCN(CC(C)(C)O)CC3)n2n1,,ClCCl,,CCN(CC)CC,,val
US20120270875A1,CCOC(=O)c1c(C)nc(NCCCc2cc(O)ccc2C)nc1C>>Cc1ccc(O)cc1CCCNc1nc(C)c(C(=O)O)c(C)n1,,C1COCCO1,O,[Li+].[OH-],,val
US20130150343A1,CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)n(-c2ccc(O[Si](C)(C)C(C)(C)C)cc2)n1>>CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)n(-c2ccc(O)cc2)n1,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040087548A1,CI.O=[N+]([O-])c1ccc(O)nc1>>Cn1cc([N+](=O)[O-])ccc1=O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120040981A1,COC(=O)CS.N#CC=C(Cl)c1ccncc1>>COC(=O)c1sc(-c2ccncc2)cc1N,,CO,,C[O-].[Na+],,val
US05525711,Cc1cnc2c(N)nc(=O)[nH]c2n1.O=C(Cl)c1ccccc1>>Cc1cnc2c(NC(=O)c3ccccc3)nc(=O)[nH]c2n1,,c1ccncc1,,,,val
US05270329,NS(=O)(=O)c1ccc2c(c1)OCO2.O=C=Nc1ccc(Cl)cc1>>O=C(Nc1ccc(Cl)cc1)NS(=O)(=O)c1ccc2c(c1)OCO2,,CC(C)=O,,O,[Na+].[OH-],val
US20150368273A1,COC1CCc2nccn2C1>>OC1CCc2nccn2C1,,ClCCl,,BrB(Br)Br,O,val
US20090318412A1,CC(C)(C)OC(=O)N1CCNC(CO)C1.O=C(O)c1ccc(F)nc1F>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(F)nc2F)C(CO)C1,,C1CCOC1,O,CCN(CC)CC,O=S(Cl)Cl,val
US20120309966A1,Cc1nccn2c(N3CCNCC3)ncc12>>Cc1nccn2c(N3CCNCC3)ncc12,,CO,,Cl,,val
US05187161,COc1ccc(O)c(C(C)(C)C)c1.O=CC=O>>COc1cc2c(c(C(C)(C)C)c1)OC(=O)C2,,CC(=O)O,,Cl,,val
US06066641,COc1ccc(Cn2c(=O)[nH]c(=O)c3[nH]c(C(C)C)nc32)cc1OC1CCCC1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>COc1ccc(Cn2c(=O)[nH]c(=S)c3[nH]c(C(C)C)nc32)cc1OC1CCCC1,,c1ccncc1,,[Na+].[OH-],,val
US20080103104A1,NC(=O)c1ccc(I)c([N+](=O)[O-])c1>>NC(=O)c1ccccc1,,CC#N,,,,val
US20160176850A1,CC(C)(C)OC(=O)N1CCC(c2ccc(N)c(C(N)=O)n2)CC1.Cl>>Cl.NC(=O)c1nc(C2CCNCC2)ccc1N,,C1COCCO1,,,,val
US06333330B1,CCO.CCOC(=O)C1C=CN(C)N1O>>CCOC(=O)C1=CN(C)N(OCC)C1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110262352A1,CCOC(=O)c1cccnc1N1CCN(C(=O)[C@H]2COc3ccccc3O2)CC1>>OCc1cccnc1N1CCN(C[C@H]2COc3ccccc3O2)CC1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20120071489A1,CC(C)(C)c1ccccc1N1CCN(C(=O)c2ccc(N)cc2)CC1.O=C=NCCCl>>CC(C)(C)c1ccccc1N1CCN(C(=O)c2ccc(N3CCNC3=O)cc2)CC1,,C1CCOC1,,O,[H-].[Na+],val
US20140148433A1,CCOC(=O)C(C)=O.Nc1ccc(-c2nn(Cc3ccccc3F)c3ncccc23)nc1N>>Cc1nc2ccc(-c3nn(Cc4ccccc4F)c4ncccc34)nc2[nH]c1=O,,CCO,,O=S(=O)(O)O,,val
US04496560,CC(C)(C)OC(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(c3cnc(N)s3)CSC12.O=C(Cl)c1cccs1>>CC(C)(C)OC(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(c3cnc(NC(=O)c4cccs4)s3)CSC12,,CCN(CC)CC,,,,val
US20040102432A1,CNCCN1CCC(Oc2ccc(F)c(F)c2)CC1.COc1cccc(C(=O)Cl)c1>>COc1cccc(C(=O)N(C)CCN2CCC(Oc3ccc(F)c(F)c3)CC2)c1.Cl,,C1CCOC1,,CCN(CC)CC,,val
US20130158040A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1c(F)cccc1Cl>>O=S(=O)(Oc1c(F)cccc1Cl)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US20100168131A1,CC(C)(C)OC(=O)N1C[C@H]2C[C@H]2C[C@H]1CN.FC(F)(F)c1cnc(Br)cn1>>CC(C)(C)OC(=O)N1C[C@H]2C[C@H]2C[C@H]1CNc1cnc(C(F)(F)F)cn1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20070167421A1,CI.O=C1N=C(S)NC(=O)C1Cc1ccccc1>>CSC1=NC(=O)C(Cc2ccccc2)C(=O)N1,,CO,,Cl,C[O-].[Na+],val
US05538960,C[C@]12CC[C@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C=O)CC[C@]12O.NNC1=NCCN1>>C[C@]12CC[C@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](/C=N/NC3=NCCN3)CC[C@]12O,,C1COCCO1,O,Br,,val
US20090082367A1,CC(C)(C(=O)NN)c1ccccn1.O=C(Cl)C1CC1>>CC(C)(C(=O)N(N)C(=O)C1CC1)c1ccccn1,,ClCCl,,CCN(CC)CC,,val
US20080076784A1,N#Cc1ccc(C2(O)CCCc3ncncc32)cc1>>N#Cc1ccc(C2=CCCc3ncncc32)cc1,,Cl,,O=C([O-])O.[Na+],,val
US20050234265A1,COc1cc(C(Cl)=C(Cl)Cl)cc(C(Cl)=C(Cl)Cl)c1>>Oc1cc(C(Cl)=C(Cl)Cl)cc(C(Cl)=C(Cl)Cl)c1,,ClCCl,,BrB(Br)Br,,val
US04929741,C#CCOC(C)OCC.COc1ccc(C=O)cc1>>CCOC(C)OCC#CC(O)c1ccc(OC)cc1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20040024010A1,CCCC(=O)c1ccc2c(c1)CC(=O)N2>>CCCCc1ccc2c(c1)CC(=O)N2,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20120101136A1,CCOC(=O)CCCOc1ccc(-c2noc(-c3ccc(OC(C)C)c(Cl)c3)n2)c(CC)c1>>CCc1cc(OCCCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(Cl)c2)n1,,CC(C)O,O,[Na+].[OH-],,val
US20090197862A1,CNC.Nc1ncc(-c2cnn([C@@H]3CN[C@@H](C(=O)O)C3)c2)cc1-c1nc2ccccc2s1>>CN(C)C(=O)[C@H]1C[C@H](n2cc(-c3cnc(N)c(-c4nc5ccccc5s4)c3)cn2)CN1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20160046618A1,CC(C)(C)OC(=O)N(COCC[Si](C)(C)C)C1=N[C@](CF)(c2cc(Br)ccc2F)[C@@H]2C[C@]2(C=O)S1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>CC(C)(C)OC(=O)N(COCC[Si](C)(C)C)C1=N[C@](CF)(c2cc(Br)ccc2F)[C@@H]2C[C@]2(c2cnco2)S1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20050124683A1,Cc1ccc(C)c(C(=O)O)c1.O=S(=O)(O)O>>Cc1cc(O)c(C)c(C(=O)O)c1,,O=S(=O)(O)O,,[Na+].[OH-],,val
US05145865,COC(=O)c1ccc(OCC2CC(=O)N(c3ccc(NC(C)=O)cc3)C2)cc1>>COC(=O)c1ccc(OCC2CC(=O)N(c3ccc(N)cc3)C2)cc1,,CO,,O=S(=O)(O)O,,val
US20040242572A1,COC(OC)c1ccc(CO)cn1.O=S(Cl)Cl>>COC(OC)c1ccc(CCl)cn1,,ClCCl,,,,val
US04555263,CCCCS.O=Cc1ccc(Cl)c([N+](=O)[O-])c1>>CCCCSc1ccc(C=O)cc1[N+](=O)[O-],,,,[Na],,val
US04264599,CN1CCN(C2CCNCC2)C1=O.OC(CCl)COc1cccnc1Cl>>CN1CCN(C2CCN(CC(O)COc3cccnc3Cl)CC2)C1=O,,CC(C)O,,,,val
US20090312342A1,Cc1ccc2c(N3CC[C@@H](CNC(=O)OCC(C)(C)C)C3)nc(-c3ccccc3O)nc2c1.Cl>>Cc1ccc2c(N3CC[C@@H](CNC(=O)OCC(C)(C)C)C3)nc(-c3ccccc3O)nc2c1.Cl,,ClCCl,,CCOCC,,val
US20030078249A1,CCOC(=O)c1ccc(OC[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1>>CC(C)(C)OC(=O)N1CCC[C@H]1COc1ccc(C(=O)O)cc1,,CO,,[Na+].[OH-],,val
US20130289012A1,CC(C)(C)OC(=O)N1CCC(c2noc([C@@H]3CC[C@@H]4CN3C(=O)N4OCc3ccccc3)n2)CC1>>O=C1N2C[C@@H](CC[C@H]2c2nc(C3CCNCC3)no2)N1OCc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060276508A1,CCOc1cc(C=O)cc(OCC)c1-n1cccc1.Cc1cc(C(=O)NC2CCNCC2)cc(C)c1C(=O)O>>CCOc1cc(CN2CCC(NC(=O)c3cc(C)c(C(=O)O)c(C)c3)CC2)cc(OCC)c1-n1cccc1,,CC(=O)O,CCO,CCN(C(C)C)C(C)C,[BH3-]C#N.[Na+],val
US20050227959A1,CNCCc1ccc(F)cc1.O=C1CCCc2c(S(=O)(=O)Cl)csc21>>CN(CCc1ccc(F)cc1)S(=O)(=O)c1csc2c1CCCC2=O,,C1CCOC1,,CCN(CC)CC,,val
US20090023703A1,COc1ccc(C(=O)CBr)cc1.O=C1NC(=O)c2ccccc21>>COc1ccc(C(=O)CN2C(=O)c3ccccc3C2=O)cc1,,CN(C)C=O,,[K],,val
US05733914,CCCCN.CSc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1>>CCCCNN1C=c2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2=NC1,,CN(C)C=O,,,,val
US05965562,CC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc([N+](=O)[O-])cc2)C1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(=O)N(C(=O)OC(C)(C)C)[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc([N+](=O)[O-])cc2)C1,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,,val
US20100311966A1,CCOC(=O)c1cccc2nc(Br)sc12.CCc1[nH]c(C(=O)N[C@@H]2CCN(C(=O)C(F)(F)F)C[C@@H]2NC(=O)OC(C)(C)C)nc1Cl>>CCOC(=O)c1cccc2nc(N3CC[C@@H](NC(=O)c4nc(Cl)c(CC)[nH]4)[C@@H](NC(=O)OC(C)(C)C)C3)sc12,,CO,,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20160009704A1,C#CCCCCn1cc(C(=O)OC)nn1>>C#CCCCCn1cc(C(=O)O)nn1,,CO,O,[Li]O,,val
US20080269293A1,CI.Cc1cc(Oc2ccccc2NC(=O)Nc2ccc(C3CCNCC3)cc2)n(-c2ccccc2Cl)n1>>Cc1cc(Oc2ccccc2NC(=O)Nc2ccc(C3CCN(C)CC3)cc2)n(-c2ccccc2Cl)n1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20050137224A1,CCOC(=O)[C@@H]1[C@@H]2CC[C@@H]([C@@H](O)[C@H]2O)N1[C@H](C)c1ccccc1>>CCOC(=O)[C@H]1N[C@H]2CC[C@@H]1[C@H](O)[C@@H]2O,,CO,,,,val
US20090105242A1,CCN1CCN(c2ccc(Nc3ccc(Cl)n4ncnc34)cc2)CC1.COc1cc(B(O)O)ccn1>>CCN1CCN(c2ccc(Nc3ccc(-c4ccnc(OC)c4)n4ncnc34)cc2)CC1,,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20020037888A1,CCOC(=O)C(=O)OCC.CNC(C)O>>CN1CCOC(=O)C1=O,,Cc1ccccc1,,,,val
US20120101086A1,CC(C)Oc1ccc(-c2nnc(-n3cc4c(n3)CCN(C(=O)OC(C)(C)C)CC4)s2)cc1Cl.CC(C)Oc1ccc(-c2nnc(-n3ncc4c3CNC(C(=O)OC(C)(C)C)CC4)s2)cc1Cl>>CC(C)Oc1ccc(-c2nnc(-n3cc4c(n3)CCNCC4)s2)cc1Cl.CC(C)Oc1ccc(-c2nnc(-n3ncc4c3CNCCC4)s2)cc1Cl,,C1COCCO1,CO,Cl,,val
US05023378,CCc1c(CCNC(=O)C(F)(F)F)ccc(OC)c1OC.COC(=O)CCCCC(=O)Cl>>CCc1c(CCNC(=O)CCCCC(=O)OC)ccc(OC)c1OC,,ClCCl,,CCN(CC)CC,,val
US05405865,COS(=O)(=O)OC.OCc1ccc(CO)o1>>COCc1ccc(CO)o1,,C1CCOC1,CN(C)C=O,Cl,[H-].[Na+],val
US04661438,COS(=O)(=O)C(F)(F)F.Cc1nc2c(ccc3ccccc32)[te]1>>Cc1[te]c2ccc3ccccc3c2[n+]1C.O=S(=O)([O-])C(F)(F)F,,ClCCl,,,,val
US07005440B1,Cc1cccc(CSc2cccc(OCc3ccc4ccccc4n3)c2)c1C(=O)OCC(C)C.O=C(OO)c1cccc(Cl)c1>>Cc1cccc(CS(=O)c2cccc(OCc3ccc4ccccc4n3)c2)c1C(=O)OCC(C)C,,ClCCl,,,,val
US20040053826A1,Nc1ccc2c(c1)CCN(C(=O)C(F)(F)F)CC2.O=C(O)CCN1CCN(Cc2ccccc2)CC1>>O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccc2c(c1)CCN(C(=O)C(F)(F)F)CC2,,CN(C)C=O,O,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20150158865A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1(c2ccc(Br)cc2)CCNCC1>>CC(C)(C)OC(=O)N1CCC(C)(c2ccc(Br)cc2)CC1,,ClCCl,O,,,val
US20160244429A1,ClCCNCCCl.Nc1ccc(N2CCCCC2=O)cc1>>O=C1CCCCN1c1ccc(N2CCNCC2)cc1,,CCCCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20140163012A1,Cl.O=C1CN(CCc2ccc(Cl)cn2)CCN1c1ccc2c3c(oc2c1)CCCNC3>>Cl.O=C1CN(CCc2ccc(Cl)cn2)CCN1c1ccc2c3c(oc2c1)CCCNC3,,CO,,CCOCC,,val
US20040082611A1,CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2cc3cc(Cl)ccc3[nH]2)CC1CC(=O)O.CS(N)(=O)=O>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2cc3cc(Cl)ccc3[nH]2)CC1CC(=O)NS(C)(=O)=O,,C1CCOC1,,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20140135316A1,CC1(C)OB(c2ccc(=O)[nH]c2)OC1(C)C.Cc1nnc2n1-c1ccc(Br)cc1N(c1ccc(Cl)cn1)C[C@H]2C>>Cc1nnc2n1-c1ccc(-c3ccc(=O)[nH]c3)cc1N(c1ccc(Cl)cn1)C[C@H]2C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110172203A1,Nc1ncccc1-c1nc2cc(Br)cnc2n1-c1ccc(CNC(=O)c2ccccc2)cc1.OCc1ccc(B(O)O)cc1>>Nc1ncccc1-c1nc2cc(-c3ccc(CO)cc3)cnc2n1-c1ccc(CNC(=O)c2ccccc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20090182025A1,CI.C[C@@H]1C[C@H]1C(=O)Nc1snc(-c2ccccc2)c1Br>>Cc1c(-c2ccccc2)nsc1NC(=O)[C@@H]1C[C@H]1C,,C1CCOC1,,[Li]CCCC,,val
US20090048454A1,CC(C)(C)[Si](C)(C)Cl.NC(=O)[C@@H]1C[C@H](F)CN1C(=O)CO>>CC(C)(C)[Si](C)(C)OCC(=O)N1C[C@@H](F)C[C@H]1C(N)=O,,CN(C)C=O,,c1c[nH]cn1,,val
US05932601,CCOc1cc(C=O)ccc1OCc1coc(-c2ccccc2)n1.COC(=O)CP(=O)(OC)OC>>CCOc1cc(C=CC(=O)OC)ccc1OCc1coc(-c2ccccc2)n1,,CN(C)C=O,,CO,C[O-].[Na+],val
US05142056,C=C(C(=O)O)C(C)C.OCc1ccccc1>>C=C(C(=O)OCc1ccccc1)C(C)C,CN(C)c1ccncc1,CCOCC,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150175623A1,Clc1ncnc2sc(-c3ccco3)c(Br)c12.O=C1CCC(=O)N1Cl>>Clc1ccc(-c2sc3ncnc(Cl)c3c2Br)o1,,C1CCOC1,,O=C(O)C(F)(F)F,,val
US20110136819A1,Fc1cc(F)cc(-c2ccc(Cl)nn2)c1.O=CO>>O=c1ccc(-c2cc(F)cc(F)c2)n[nH]1,,O,O=CO,[Na+].[OH-],,val
US05922727,BrC(Br)(Br)Br.CC(C)(C)[Si](C)(C)OCC1C=C(CO)CC1CO[Si](C)(C)C(C)(C)C>>CC(C)(C)[Si](C)(C)OCC1C=C(CBr)CC1CO[Si](C)(C)C(C)(C)C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20110086759A1,O=C(O)c1nc(C2CC2)nc(O)c1Cl.O=P(Cl)(Cl)Cl>>O=C(O)c1nc(C2CC2)nc(Cl)c1Cl,,O,,,,val
US20150252059A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)C1=N[C@](C)(c2cc([N+](=O)[O-])ccc2F)CS(=O)(=O)[C@]1(CF)CCI>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)C1=N[C@](C)(c2cc([N+](=O)[O-])ccc2F)[C@@H]2CC[C@@]1(CF)S2(=O)=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05914339,C[C@H](Cc1ccc2c(c1)OC(C(=O)OCC(C)(C)C)(C(=O)OCC(C)(C)C)O2)NC[C@H](O)c1cccc(Cl)c1>>C[C@H](Cc1ccc2c(c1)OC(C(=O)O)(C(=O)OCC(C)(C)C)O2)NC[C@H](O)c1cccc(Cl)c1,,ClC(Cl)Cl,,[Br-].[K+],,val
US05856309,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CC=C(CO)C1>>CC(=O)OCC1=CCN(C(=O)OC(C)(C)C)C1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20100261709A1,Brc1ccsc1.CC(C)(C)OC(=O)N1CCNC(=O)C1>>CC(C)(C)OC(=O)N1CCN(c2ccsc2)C(=O)C1,[Cu]I,C1COCCO1,CCOC(C)=O,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20100105727A1,CC(C)C(=O)N1CCC(CBr)CC1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)C(=S)N1CCC(CBr)CC1,,C1CCOC1,,,,val
US20160002175A1,Cc1ccc2[nH]c(C)c(CCN)c2c1.Cc1cccc(-c2cc(Cl)nc(N)n2)c1C>>Cc1ccc2[nH]c(C)c(CCNc3cc(-c4cccc(C)c4C)nc(N)n3)c2c1,,CO,,,,val
US20110294781A1,C1COCCN1.Clc1cc(Cl)n2nc(-c3ccccc3)cc2n1>>Clc1cc(N2CCOCC2)n2nc(-c3ccccc3)cc2n1,,C1COCCO1,,,,val
US20020045180A1,C#CCBr.O=C1c2ccccc2C(=O)N1CCO>>C#CCOCCN1C(=O)c2ccccc2C1=O,,CN(C)C=O,,CO,[H-].[Na+],val
US03932167,ClC(Cl)(Cl)c1nc(C(Cl)(Cl)Cl)nc(C(Cl)(Cl)Cl)n1.NCc1ccccc1>>ClC(Cl)(Cl)c1nc(NCc2ccccc2)nc(C(Cl)(Cl)Cl)n1,,c1ccccc1,,CCN(CC)CC,,val
US20060154926A1,CCCCNC(=O)C(C)C[C@H](O)[C@H](C[C@H](Cc1ccc(C(C)(C)C)cc1)C(C)C)NC(=O)OC(C)(C)C.Cl>>CCCCNC(=O)C(C)C[C@H](O)[C@@H](N)C[C@H](Cc1ccc(C(C)(C)C)cc1)C(C)C.Cl,,C1COCCO1,,,,val
US20030199440A1,C1CC2(CCN1)OCCO2.CS(=O)(=O)Cl>>CS(=O)(=O)N1CCC2(CC1)OCCO2,,CCOCC,,CCN(CC)CC,,val
US07396936B1,CC(C)CC(=N)CC(N)=O.CCOC(=O)C=C(N)CCc1ccc(F)cc1.O=Cc1ccc(C(=O)NCc2cccnc2)cc1>>CCOC(=O)C1=C(CCc2ccc(F)cc2)NC(CC(C)C)=C(C(N)=O)C1c1ccc(C(=O)NCc2cccnc2)cc1,,CCO,,,,val
US05649045,Nc1ccc(-c2ccc(N)cc2C(F)(F)F)c(C(F)(F)F)c1.O=C1OC(=O)c2cc(-c3ccc4c(c3)C(=O)OC4=O)ccc21>>Nc1ccc(-c2ccc(N)cc2C(F)(F)F)c(C(F)(F)F)c1.O=C1OC(=O)c2cc(-c3ccc4c(c3)C(=O)OC4=O)ccc21,,CN1CCCC1=O,,,,val
US04317820,CCOC=C(C(=O)[O-])C(=O)OCC.Clc1ccc2c(c1)CCCN2>>O=C(O)c1cn2c3c(cc(Cl)cc3c1=O)CCC2,,O,,CCO,[Na+].[OH-],val
US04771055,CN(C)c1c(F)c(F)c(F)c(F)c1C(=O)O.O=C(Cl)C(=O)Cl>>CN(C)c1c(F)c(F)c(F)c(F)c1C(=O)Cl,CN(C)C=O,ClCCl,,,,val
US20100305096A1,CN(C)C1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1.c1ccc2[nH]cnc2c1>>CN(C)C1CCN(Cc2cc3nc(-n4cnc5ccccc54)nc(N4CCOCC4)c3s2)CC1,,C1COCCO1,,Cl,,val
US20160145244A1,CC(C)S(=O)(=O)c1ccccc1Nc1ncnc(Cl)n1.Cc1cc(N)c2c(c1C1CCN(C)CC1)C[C@@H](C)O2>>Cc1cc(Nc2ncnc(Nc3ccccc3S(=O)(=O)C(C)C)n2)c2c(c1C1CCN(C)CC1)C[C@@H](C)O2,,CC(C)O,,O=C(O)C(F)(F)F,,val
US06492416B1,CSc1ccc(C2=C(c3ccccc3)C(=O)C(C)(C)O2)cc1Br.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ccc(C2=C(c3ccccc3)C(=O)C(C)(C)O2)cc1Br,,ClCCl,,[Na+].[OH-],,val
US20120316147A1,CC(C)C[C@H](NC(=O)c1ccc(Br)c(Cl)n1)C(N)=O.Oc1ccc(F)cc1>>CC(C)C[C@H](NC(=O)c1ccc(Br)c(Oc2ccc(F)cc2)n1)C(N)=O,,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20020019402A1,O=[N+]([O-])c1ccc2ccc([N+](=O)[O-])cc2c1>>Nc1ccc2ccc(N)cc2c1,[Pd],CCO,,,,val
US20090318479A1,O=C(O)c1cc(Cl)c(Cl)cc1[N+](=O)[O-].O=c1[nH]c(-c2cc3ccccc3o2)nc2cc(Cl)c(Cl)cc12>>NC(=O)c1cc(Cl)c(Cl)cc1[N+](=O)[O-],,O=S(Cl)Cl,,,,val
US08471005B2,CN(c1ccccc1-c1cc(OCOCC[Si](C)(C)C)c2cnc(S(C)=O)nn12)S(C)(=O)=O>>CN(c1ccccc1-c1cc(OCOCC[Si](C)(C)C)c2cnc(O)nn12)S(C)(=O)=O,,CC(=O)O,,O,[Na+].[OH-],val
US20150291595A1,CN(C)CCCl.Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cn[nH]c3)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12>>Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cnn(CCN(C)C)c3)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110142796A1,CC(C)(C)OC(=O)N1CCNCC1.ClCc1ccc(Cl)nc1>>CC(C)(C)OC(=O)N1CCN(Cc2ccc(Cl)nc2)CC1,,CC#N,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20130324531A1,COCCO.COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F>>COCCOC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(c3ccc(Cl)cc3F)[C@H]2c2cccc(Cl)c2F)c(OC)c1,,C1CCOC1,,[H-].[Na+],,val
US05665878,CC(=O)NN=C(c1ccc([N+](=O)[O-])cc1)c1cc2c(cc1C[C@H](C)O)OCO2>>CC(=O)N1N=C(c2ccc([N+](=O)[O-])cc2)c2cc3c(cc2C[C@H]1C)OCO3,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06204221B1,N.O=C(Cl)c1ncc(Cl)cc1F>>NC(=O)c1ncc(Cl)cc1F,,C1CCOC1,,,,val
US20140011800A1,CC[C@H]1CN(C(=O)OCc2ccccc2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(CN)nc3)cc12.COCC(=O)O>>CC[C@H]1CN(C(=O)OCc2ccccc2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(CNC(=O)COC)nc3)cc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20150165063A1,CC(C)(C)OC(=O)/C=C/c1ccc(/C=C/C(=O)[O-])cc1NC(=O)CCNC(=O)CCCCCN1C(=O)C=CC1=O>>O=C(O)/C=C/c1ccc(/C=C/C(=O)O)c(NC(=O)CCNC(=O)CCCCCN2C(=O)C=CC2=O)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140249134A1,C=C[Sn](CCCC)(CCCC)CCCC.Cc1nc(Cl)cc(-n2nc(C)nc2C)n1>>C=Cc1cc(-n2nc(C)nc2C)nc(C)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20100004221A1,COC(=O)c1cccc2c1ccn2CC1CC1.NN>>NNC(=O)c1cccc2c1ccn2CC1CC1,,CCO,,O,O,val
US20120010414A1,Cn1cnc(C(=O)O)c1.OCCNC1CCOCC1>>Cn1cnc(C(=O)N(CCO)C2CCOCC2)c1,,CC#N,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06407129B1,O=C(Cl)OCCl.OCC1COCO1>>O=C(OCCl)OC1COCOC1,,CCOCC,,c1ccncc1,,val
US04686220,CCOC(=O)N1CCNCC1.O=C1C(Cl)=C(Cl)C(=O)c2ccccc21>>CCOC(=O)N1CCN(C2=C(Cl)C(=O)c3ccccc3C2=O)CC1,,CCO,,,,val
US20100075948A1,CC(C)(C)C[C@@H]1N[C@@H](C(=O)NCCCNC(=O)OC(C)(C)C)[C@H](c2cccc(Cl)c2)[C@@]1(C#N)c1ccc(Cl)cc1>>CC(C)(C)CC1NC(C(=O)NCCCN)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US03959478,CCOC(=O)Cl.NC(=O)N(O)c1cc(Cl)c(Cl)c(Cl)c1>>O=c1[nH]c(=O)n(-c2cc(Cl)c(Cl)c(Cl)c2)o1,,[Na+],[OH-],O,,val
US20040132733A1,[N-]=[N+]=NCCc1ccc(C(N)=O)cc1>>NCCc1ccc(C(N)=O)cc1,[Pd],CCO,,[H][H],,val
US20120010188A1,Nc1ccc(Br)cn1.O=C(CBr)c1ccc(F)c(F)c1>>Fc1ccc(-c2cn3cc(Br)ccc3n2)cc1F,,CCO,,[Na+].[OH-],,val
US20050256078A1,CCOP(=O)(OCC)C(C#N)CC(=CCc1c(OC)c(C)c2c(c1OCC[Si](C)(C)C)C(=O)OC2)CC>>CCC(=CCc1c(O)c2c(c(C)c1OC)COC2=O)CC(C#N)P(=O)(O)O,,ClCCl,O=C(O)C(F)(F)F,,,val
US06469038B1,CC(C)(C)NC(=O)C(Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(Cc1cn(C(=O)OC(C)(C)C)cn1)NC(=O)OC(C)(C)C.CC(C)(C)NC(=O)C(Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(N)Cc1c[nH]cn1>>CC(C)(C)NC(=O)C(Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(Cc1c[nH]cn1)NCC1CCCCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110052578A1,CC(C)(C)OC(=O)Nc1c(F)ccc(Br)c1F>>Nc1c(F)ccc(Br)c1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US06689884B1,CCOC(OCC)N(C)C.Nc1ncnc2c1ncn2[C@H]1CC[C@@H]2CC(=O)N[C@H]1C2>>CN(C)C=Nc1ncnc2c1ncn2[C@H]1CC[C@@H]2CC(=O)N[C@H]1C2,,CN(C)C=O,,,,val
US20150051395A1,COC(=O)c1c(F)cc(N)cc1F.O=S(=O)(Cl)c1ccc(Br)cc1>>COC(=O)c1c(F)cc(NS(=O)(=O)c2ccc(Br)cc2)cc1F,,ClCCl,,c1ccncc1,,val
US05571816,CC(C)N(C(=O)c1cnc(N2CC(C)(C)NC2=O)nc1N)c1cccc(C(F)(F)F)c1.Cl>>CC(C)N(C(=O)c1cnc(N2CC(C)(C)NC2=O)nc1N)c1cccc(C(F)(F)F)c1.Cl,,CC(C)=O,CCOCC,,,val
US20020147214A1,CSC1=c2cc(C#N)ccc2=NC1=O.[OH-]>>N#Cc1ccc(N)c(C(=O)O)c1,,O,,CO,,val
US20090054421A1,CCOC(=O)c1cc2c(C(=O)c3ccc4c(c3)OCO4)nc(N)nc2s1.CON>>CCOC(=O)c1cc2c(C(=NOC)c3ccc4c(c3)OCO4)nc(N)nc2s1,,CO,,Cl,,val
US20040242584A1,CC(C)(C)OC(=O)NC1c2cc(N)ccc2CC1O.O=C(ON1C(=O)CCC1=O)c1ccc(-c2ccccc2)cc1>>Nc1ccc2c(c1)C(NC(=O)c1ccc(-c3ccccc3)cc1)C(O)C2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030069284A1,CCNc1ccccn1.COc1cc(C(=O)O)ccc1NC(=O)Nc1cnc(C)cn1>>COc1cc(C(=O)NCCc2ccccn2)ccc1NC(=O)Nc1cnc(C)cn1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040204448A1,BrCCC1CC1.O=Cc1ccc(OC(F)F)c(O)c1>>O=Cc1ccc(OC(F)F)c(OCC2CC2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150315141A1,CC(C)(C)CC(=O)N1C(=O)OC[C@H]1Cc1ccccc1.ClCOCc1ccccc1>>CC(C)(C)[C@@H](CO)C(=O)N1C(=O)OC[C@H]1Cc1ccccc1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090291973A1,CC(C(=O)O)c1ccccc1.CCc1nc2cc(F)ccc2c(=O)n1N>>CCc1nc2cc(F)ccc2c(=O)n1NC(=O)C(C)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20110212088A1,CC(C)(C)SCCCCCCCCCCCCCCCCOC[C@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)OC1CCCCO1>>CC(C)(C)SCCCCCCCCCCCCCCCCOC[C@H](CO)OC1CCCCO1,,C1CCOC1,,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20110237791A1,COc1nc(C(OC)OC)ccc1CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C>>COc1nc(C=O)ccc1CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,C1CCOC1,,Cl,O,val
US04438128,NCCNc1nc(N)nc2nc[nH]c12.c1ccc(OCC2CO2)cc1>>Nc1nc(NCCNCC(O)COc2ccccc2)c2[nH]cnc2n1,,CO,,,,val
US20070203072A1,CCOC(=O)C12CC1C=CCCCCNC(=O)C1CC(Oc3cc(-c4ccccc4)nc4cc(OC)ccc34)CC1C(=O)N2>>COc1ccc2c(OC3CC4C(=O)NCCCCC=CC5CC5(C(=O)O)NC(=O)C4C3)cc(-c3ccccc3)nc2c1,,C1CCOC1,O,CO,Cl,val
US20130085148A1,CC(=O)c1ccc(Br)cn1.CC1(C)OB(c2ccc(C#N)nc2)OC1(C)C>>CC(=O)c1ccc(-c2ccc(C#N)nc2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US06288082B1,CCOc1cc2ncc(C#N)c(Cl)c2cc1OCC.Cc1cc(=O)oc2cc(N)ccc12>>CCOc1cc2ncc(C#N)c(Nc3ccc4c(C)cc(=O)oc4c3)c2cc1OCC,,COCCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20060009453A1,Cc1ccc(N)c(C)c1Oc1ncccc1-c1ccncn1.O=C(Cl)c1cccc(C(F)(F)F)c1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)c(C)c1Oc1ncccc1-c1ccncn1,,ClCCl,,CCN(CC)CC,,val
US06936602B1,CC(C)=CCBr.CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3)cc1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3CC=C(C)C)cc1,,C1CCOC1,,O,[H-].[Na+],val
US20090270374A1,ClCCl.NC[C@H]1CN(CCn2c(=O)ccc3ncc(F)cc32)C[C@H]1O.O=Cc1ccc2c(n1)NC(=O)CS2>>Cl.O=C1CSc2ccc(CNC[C@H]3CN(CCn4c(=O)ccc5ncc(F)cc54)C[C@H]3O)nc2N1,,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US20090227640A1,Br.CC(C)(C)c1ccc(COc2ccc(F)cc2CO)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)c1ccc(COc2ccc(F)cc2C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1.[Br-],,CC#N,,,,val
US20160089374A1,CO.O=C(O)c1cccc(C(F)(F)F)n1>>COC(=O)c1cccc(C(F)(F)F)n1,,CO,,CC(=O)Cl,,val
US20090233918A1,Cn1c(Cl)nc(-c2ccncn2)cc1=O.c1ccc2c(c1)CC[C@H]1NCCO[C@@H]21>>Cn1c(N2CCO[C@H]3c4ccccc4CC[C@H]32)nc(-c2ccncn2)cc1=O,,C1CCOC1,,CCN(CC)CC,Cl,val
US20080207635A1,CN(C)c1ccc(-c2ccnc(-n3cc(C(=O)O)c(N)n3)n2)cc1.CN1CCN(CCc2ccc(N)cc2)CC1>>CN1CCN(CCc2ccc(NC(=O)c3cn(-c4nccc(-c5ccc(N(C)C)cc5)n4)nc3N)cc2)CC1,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US05840749,CC(C)(Cc1ccc(OCc2ccccc2C(=O)O)cc1)C(=O)O>>CC(C)(Cc1ccc2c(c1)C(=O)c1ccccc1CO2)C(=O)O,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20160052884A1,CCI.COc1cc(I)c(O)cn1>>CCOc1cnc(OC)cc1I,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06080743,COc1nc2cc([N+](=O)[O-])cc(C)c2nc1OC.O=C1CCC(=O)N1Br>>COc1nc2cc([N+](=O)[O-])cc(CBr)c2nc1OC,,ClC(Cl)(Cl)Cl,,,,val
US20080188532A1,C=O.CNC.Cc1cc2c([N+](=O)[O-])cccc2[nH]1>>Cc1[nH]c2cccc([N+](=O)[O-])c2c1CN(C)C,,CC(=O)O,,[Na+].[OH-],,val
US20150057286A1,Brc1cncc2cc[nH]c12.CI>>Cn1ccc2cncc(Br)c21,,CN(C)C=O,ClCCl,[H-].[Na+],,val
US20120101134A1,CC(C)(C)OC(=O)/C=C/c1cccc(C#N)c1>>CC(C)(C)OC(=O)CCc1cccc(C#N)c1,[Pd],CCO,,[H][H],,val
US20090023729A1,CCOC(=O)CCCBr.O=C(OCc1ccccc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ncc(O)cn1>>CCOC(=O)CCCOc1cnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)OCc2ccccc2)nc1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20080139631A1,CCCc1cc2c(C(F)(F)F)c(C#N)ccc2n1CC(=N)NO.O=C(Cl)c1cnccc1Cl>>CCCc1cc2c(C(F)(F)F)c(C#N)ccc2n1Cc1noc(-c2cnccc2Cl)n1,,CC#N,,CCN(CC)CC,Cl,val
US20120128686A1,COCCCO.O=[N+]([O-])c1ccc(Cl)nc1OC1CCOCC1>>COCCCOc1ccc([N+](=O)[O-])c(OC2CCOCC2)n1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20040014766A1,COC(=O)c1sccc1C(N)=O>>NC(=O)c1ccsc1C(=O)O,,CO,,[Na+].[OH-],,val
US20040014751A1,C1CCNCC1.O=c1cc(Nc2ccccc2)n(-c2ccccc2)c2nc(Cl)cc(C(F)(F)F)c12>>O=c1cc(Nc2ccccc2)n(-c2ccccc2)c2nc(N3CCCCC3)cc(C(F)(F)F)c12,,C1COCCO1,,Cl,,val
US20120010235A1,CC(C)(C)C[C@@H]1N[C@@H](C(=O)O)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F.COC(=O)c1ccc(N)cc1F>>COC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(c3ccc(Cl)cc3F)[C@H]2c2cccc(Cl)c2F)cc1F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100261755A1,CCOC(=O)CC(=O)[C@@H]1CCN(C(=O)OC)[C@@H](Cc2cccc(F)c2)C1.NO>>COC(=O)N1CC[C@@H](c2cc(=O)[nH]o2)C[C@@H]1Cc1cccc(F)c1,,CO,O,Cl,[Na+].[OH-],val
US20160024121A1,CC(C)(C)OC(=O)NCC=O.O=C(CN(C(=O)OCc1ccccc1)C1CCNCC1)OCc1ccccc1>>CC(C)(C)OC(=O)NCCN1CCC(N(CC(=O)OCc2ccccc2)C(=O)OCc2ccccc2)CC1,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080015203A1,CCOC(=O)c1ccc(Oc2cc(O[C@@H](C)CO)cc(C(=O)Nc3cnc(C)cn3)c2)cc1>>Cc1cnc(NC(=O)c2cc(Oc3ccc(C(=O)O)cc3)cc(O[C@@H](C)CO)c2)cn1,,C1CCOC1,O,[Li+].[OH-],,val
US20150031685A1,CN[C@H](C(=O)N1CC[C@H](OC)C1)c1ccccc1>>CN[C@H](CN1CC[C@H](OC)C1)c1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05650410,CCNCC.O=C(CCCBr)OCc1ccccc1>>CCN(CC)CCCC(=O)OCc1ccccc1,,ClCCl,,,,val
US03935314,CC(=O)OC(C)=O.Nc1ccc2nc(NC3=NCCN3)[nH]c2c1>>CC(=O)Nc1ccc2nc(NC3=NCCN3)[nH]c2c1,,CCO,,,,val
US20130116258A1,Cc1cc(N2C(=O)C3(CCC3)N(c3ccc(O)cc3)C2=S)cnc1C#N.O=C1CCC(=O)O1>>Cc1cc(N2C(=O)C3(CCC3)N(c3ccc(OCCO)cc3)C2=S)cnc1C#N,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040259923A1,CC(=O)Nc1nc(CCc2ccc(N)cc2)c(Cc2ccc(S(C)(=O)=O)cc2)s1.CSC1=NCCS1>>CC(=O)Nc1nc(CCc2ccc(NC3=NCCS3)cc2)c(Cc2ccc(S(C)(=O)=O)cc2)s1,,COCCO,,Cl,O=C([O-])O.[Na+],val
US20070078263A1,COC(=O)CCCBr.c1ccc(Cc2ccc(OC[C@H]3CCCN3)cc2)cc1>>COC(=O)CCCN1CCC[C@@H]1COc1ccc(Cc2ccccc2)cc1,,ClCCl,,CCN(CC)CC,O,val
US20140350019A1,Cc1cc(-c2cccc(F)c2)cc(C(=O)Nc2c(F)ccc(O)c2C)c1C>>Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(O)c2C)c1C,,C1CCOC1,,,,val
US20120295884A1,C[Al](C)C.Clc1nccc2cn[nH]c12>>Cc1nccc2cn[nH]c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,[Cl-].[NH4+],,val
US04642338,COC(=O)C(C)Oc1ccc(O)cc1.O=[N+]([O-])c1ccc(F)c(F)c1>>COC(=O)C(C)Oc1ccc(Oc2ccc([N+](=O)[O-])cc2F)cc1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140275072A1,CC(C)(C)OC(=O)N1CCC[C@H]([C@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c2nccs2)C1.Cl>>CC(C)(C)[Si](O[C@H](c1nccs1)[C@H]1CCC[NH2+]C1)(c1ccccc1)c1ccccc1.Cl,,ClCCl,,,,val
US20080300242A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2.COc1cc(N2CCC(=O)CC2)ccc1[N+](=O)[O-]>>COc1cc(N2CCC(N3C[C@@H]4C[C@H]3CN4C(=O)OC(C)(C)C)CC2)ccc1[N+](=O)[O-],,ClCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US20020156081A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ncnc2c1c(I)nn2C1CCNC1>>CC(C)(C)OC(=O)N1CCC(n2nc(I)c3c(N)ncnc32)C1,,C1COCCO1,O,Cl,O=C([O-])O.[Na+],val
US20160194302A1,CCOC(=O)CCn1ccnc1CCC(=O)O.CN(C)C1CCNCC1>>CCOC(=O)CCn1ccnc1CCC(=O)N1CCC(N(C)C)CC1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04898854,CCOP(=O)(C[C@H]1CCN[C@@H](C(N)=O)C1)OCC>>NC(=O)[C@H]1C[C@@H](CP(=O)(O)O)CCN1,,ClCCl,,C[Si](C)(C)I,,val
US05736487,BrCc1nc2ccccc2s1.O=[N+]([O-])c1ccc(O)cc1>>O=[N+]([O-])c1ccc(O)c(Cc2nc3ccccc3s2)c1,,CN(C)C=O,,O,[H-].[Na+],val
US04153721,CCOC(=O)Cc1ccc(-c2ccc3oc([N+](=O)[O-])c(C)c3c2)cc1>>Cc1c([N+](=O)[O-])oc2ccc(-c3ccc(CC(=O)O)cc3)cc12,,CC(=O)O,,Cl,,val
US20100168082A1,CN(Cc1cc(Oc2ccc3c(ccn3C(=O)Nc3cc(C4CC4)n(C)n3)c2)ccn1)C(=O)OC(C)(C)C>>CNCc1cc(Oc2ccc3c(ccn3C(=O)Nc3cc(C4CC4)n(C)n3)c2)ccn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060189602A1,CCCCn1nc(C(C)C)c(O)c(C2=Nc3ccc(OC)cc3S(=O)(=O)N2)c1=O>>CCCCn1nc(C(C)C)c(O)c(C2=Nc3ccc(O)cc3S(=O)(=O)N2)c1=O,,ClCCl,,BrB(Br)Br,,val
US06008217,CC(C)(C)OC(=O)[C@@H]1CCCN2C(=O)CC[C@H](NC(=O)c3ccccc3)C(=O)N12>>CC(=O)N[C@H]1CCC(=O)N2CCC[C@@H](C(=O)O)N2C1=O,,CO,,[Br-].[K+],,val
US20090286848A1,COC(=O)C(c1ccc(C=CC(=O)Nc2ccccc2NC(=O)OC(C)(C)C)cc1)N1CCC(O)C1>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)/C=C/c1ccc(C(C(=O)O)N2CC[C@H](O)C2)cc1,,CO,,[Li+].[OH-],,val
US20040186132A1,CC1(C)CNc2ccccc2C1.O=[N+]([O-])O>>CC1(C)CNc2cc([N+](=O)[O-])ccc2C1,,O=S(=O)(O)O,,,,val
US20100113502A1,COC(=O)c1ccccc1S(=O)(=O)n1c2c(c3cc(C(=O)N4CCC(C)CC4)ccc31)CN(C(=O)OC(C)(C)C)CC2.O=C(O)C(F)(F)F>>COC(=O)c1ccccc1S(=O)(=O)n1c2c(c3cc(C(=O)N4CCC(C)CC4)ccc31)CNCC2.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20130115190A1,C=CCCC(C)C[C@@H](C)C(NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)O.CCOc1cnc(Cl)c2ccccc12>>C=CCCC(C)C[C@@H](C)C(NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Oc2ncc(OCC)c3ccccc23)C[C@H]1C(=O)O,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US05527827,CSc1cc(F)cc(C(=O)c2nccs2)c1.O=C(O)c1cccc(OO)c1C(=O)O>>CS(=O)c1cc(F)cc(C(=O)c2nccs2)c1,,CO,ClCCl,O=C([O-])O.[Na+],,val
US04894458,C1CNCCN1.CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)c(C)c21>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)c(C)c21,,CS(C)=O,,,,val
US20080292626A1,COC(=O)c1cc(C)c([N+](=O)[O-])cc1[N+](=O)[O-].COC(OC)N(C)C>>COC(=O)c1cc(C=CN(C)C)c([N+](=O)[O-])cc1[N+](=O)[O-],,Cc1ccccc1,,,,val
US04794186,O=C(O)/C(=N\OC1CCNC1=O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>Nc1nc(/C(=N/OC2CCNC2=O)C(=O)O)cs1,,O,,CO,,val
US20090253758A1,Cc1c(N[C@@H](c2nnc(-c3ccc(F)c(O[Si](C)(C)C(C)(C)C)c3)o2)[C@H](C)O[Si](C)(C)C(C)(C)C)ccc(C#N)c1Cl>>Cc1c(N[C@@H](c2nnc(-c3ccc(F)c(O)c3)o2)[C@H](C)O)ccc(C#N)c1Cl,,C1CCOC1,,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20100210619A1,Nc1ccnc2ccccc12.O=C(O)c1cc(NC2CCCCC2)ncn1>>O=C(Nc1ccnc2ccccc12)c1cc(NC2CCCCC2)ncn1,,CO,,,,val
US20030220350A1,CC(C)N1C(=O)c2ccc([N+](=O)[O-])cc2C1=O>>CC(C)N1C(=O)c2ccc(N)cc2C1=O,[Pd],C1CCOC1,CN(C)C=O,,,val
US20080009530A1,CCOC(=O)CC(C)c1ccc(OCCOC)cc1O.FC(F)(F)c1cnc(Cl)c(Cl)c1>>CCOC(=O)CC(C)c1ccc(OCCOC)cc1Oc1ncc(C(F)(F)F)cc1Cl,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US04806685,ClCC1CO1.Oc1ccc(C(c2ccccc2)C(c2ccc(Cl)cc2)C(F)(F)F)cc1>>FC(F)(F)C(c1ccc(Cl)cc1)C(c1ccccc1)c1ccc(OCC2CO2)cc1,,CO,,[Na+].[OH-],,val
US20050203107A1,CCI.Clc1ccc(Nc2nc(Cl)nc3[nH]cnc23)cc1>>CCn1cnc2c(Nc3ccc(Cl)cc3)nc(Cl)nc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04137273,CC(C)=CCCC(C)=CCBr.S>>CC(C)=CCCC(C)=CCS,,O,,CO,[Na+].[OH-],val
US20160002205A1,CC(Br)c1c(Cl)ccc(F)c1Cl.Nc1ncc(Br)cc1O>>CC(Oc1cc(Br)cnc1N)c1c(Cl)ccc(F)c1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020103229A1,O=C(Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1)C1CCCC1>>O=C(Nc1cccc(-c2n[nH]c3ccc(-c4nc[nH]n4)cc23)c1)C1CCCC1,,C1COCCO1,Cl,,,val
US20090247524A1,CS(=O)c1cc(-c2c(Cl)cc3c4c(cccc24)COC3)nc(N)n1.OCCCS>>Nc1nc(SCCCO)cc(-c2c(Cl)cc3c4c(cccc24)COC3)n1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,Cl,val
US20040116465A1,CC(C)CC(=O)Cl.CCOc1ccc(C(C)c2nc3cc(NC)ccc3n2CC2CC2)cc1>>CCOc1ccc(C(C)c2nc3cc(N(C)C(=O)CC(C)C)ccc3n2CC2CC2)cc1,CN(C)c1ccncc1,CC#N,,CCN(C(C)C)C(C)C,,val
US20060111426A1,CCc1ccccc1S.CN(C)C=O.COc1ccc(S(=O)(=O)c2c(C)n(CC(=O)O)c3ccc(C)cc23)cc1>>CCc1ccccc1Sc1c(C)n(CC(=O)[O-])c2ccc(C)cc12.[NH4+],,CN(C)C=O,,II,,val
US20120252779A1,O=C(CCn1cc([N+](=O)[O-])cn1)N1CCCCC1>>Nc1cnn(CCC(=O)N2CCCCC2)c1,[Pd],CO,,,,val
US20130225552A1,CC1(C)C(=O)N([C@@H]2C[C@H](O)C2)c2nccnc21.Oc1nc2ccccc2s1>>CC1(C)C(=O)N([C@@H]2C[C@@H](Oc3nc4ccccc4s3)C2)c2nccnc21,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US07157487B2,COc1cc(C(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc(F)c1[N+](=O)[O-]>>COc1cc(CC(=O)O)cc(F)c1[N+](=O)[O-],,CC(=O)O,,Cl,,val
US20120183660A1,[N-]=[N+]=N[C@H]1CO[C@@H]2[C@@H](NC(=O)C3CC3)CO[C@H]12>>N[C@H]1CO[C@@H]2[C@@H](NC(=O)C3CC3)CO[C@H]12,[Pd],CO,,,,val
US04861769,CCOC(=O)C(=NOC1CC1)c1nsc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>O=C(O)C(=NOC1CC1)c1nsc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,C1CCOC1,,CO,[Na+].[OH-],val
US20120270865A2,CCOC(=O)c1oc2ccc(OCc3ccccc3)cc2c1C>>Cc1c(CO)oc2ccc(OCc3ccccc3)cc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090029965A1,CC(C)(C)OC(=O)NCc1ccc(C(=O)O)cc1F.Cn1ncc2c1Nc1cc(Cl)ccc1NC2>>Cn1ncc2c1Nc1cc(Cl)ccc1N(C(=O)c1ccc(CNC(=O)OC(C)(C)C)c(F)c1)C2,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080045521A1,COC(=O)[C@H](Cc1ccc(OCCN(C(=O)OC(C)(C)C)c2ccccn2)cc1)NC(=O)c1c(Cl)cccc1Cl>>COC(=O)[C@H](Cc1ccc(OCCNc2ccccn2)cc1)NC(=O)c1c(Cl)cccc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100273764A1,CI.Oc1ccc(F)nc1>>COc1ccc(F)nc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100240658A1,COCc1cc(-c2nc(-c3ccc(F)c(CN(C)CCC(=O)OC(C)(C)C)c3)no2)ccc1-c1ccccc1C>>COCc1cc(-c2nc(-c3cccc(CN(C)CCC(=O)O)c3)no2)ccc1-c1ccccc1C,,C1COCCO1,Cl,,,val
US20120157434A1,CC(=O)NC[C@@H]1OC(=O)N2c3ccc(NCn4nnc5ccccc54)cc3C[C@@H]12>>CNc1ccc2c(c1)C[C@H]1[C@H](CNC(C)=O)OC(=O)N21,,C1CCOC1,CN1CCCC1=O,[BH4-].[Na+],,val
US20050070539A1,N#Cc1ccc(N2CCNCC2)c(Cl)c1.O=C(Cl)c1cc([N+](=O)[O-])ccc1N1CCOCC1>>N#Cc1ccc(N2CCN(C(=O)c3cc([N+](=O)[O-])ccc3N3CCOCC3)CC2)c(Cl)c1,,ClCCl,,CCN(CC)CC,,val
US20130096149A1,CC(C)(C)C(=O)Cl.COC(=O)c1cccc(N)c1Cl>>COC(=O)c1cccc(NC(=O)C(C)(C)C)c1Cl,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US05061712,C.CO.c1ccc(CNC2CCN(Cc3ccccc3)C2)cc1>>CC(C)(C)C=NC1CCNC1,[Pd],CO,,,,val
US20080070960A1,CC(C)=NO.COc1ccc(C(=O)c2ccccc2F)c(OC)c1>>COc1ccc(C(=O)c2ccccc2ON=C(C)C)c(OC)c1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20100093757A1,CCCCC(O[Si](C)(C)C(C)(C)C)C(=O)OCC.Cc1ccc(N)nc1>>CCCCC(O[Si](C)(C)C(C)(C)C)C(=O)Nc1ccc(C)cn1,,C1CCOC1,CCOC(C)=O,O,[Li]CCCC,val
US20130072487A1,CCOC(=O)CNC(=O)c1c(O)n(C(C)(C)C)c(=O)n(Cc2ccc(C(C)(C)C)cc2)c1=O>>CC(C)(C)c1ccc(Cn2c(=O)c(C(=O)NCC(=O)O)c(O)n(C(C)(C)C)c2=O)cc1,,CCO,,[Na+].[OH-],,val
US20120232068A1,CCOC(=O)CNS(=O)(=O)c1cncc(Br)c1.N>>NC(=O)CNS(=O)(=O)c1cncc(Br)c1,,CO,,,,val
US20080227770A1,CCOC(=O)CCc1ccc(C(=O)C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)CO)C2=O)cc1>>COc1cccc([C@H]2O[C@H](CC(=O)c3ccc(CCC(=O)O)cc3)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,C1CCOC1,CCO,[Na+].[OH-],,val
US20100063068A1,CN.O=C(O)c1c(-c2ccc(F)cc2)nc2ccc(Br)cn12>>CNC(=O)c1c(-c2ccc(F)cc2)nc2ccc(Br)cn12,,C1CCOC1,ClCCCl,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20130217671A1,C1COCCO1.CC(=O)c1cnc2ccc(Br)cc2c1Cl.CCN(C(C)C)C(C)C.CN(C)C=O>>CC(=O)c1cnc2ccc(Br)cc2c1N[C@@H]1CC[C@@H](CCN(C)C)CC1,,C1COCCO1,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US04320218,C1=CCC=C1.CCNCC.O=Cc1ccco1>>C=C1C=CC=C1Cc1ccco1,,O,,CO,,val
US20150191439A1,COC(CCl)(OC)OC.Nc1cscc1N>>ClCc1nc2cscc2[nH]1,,COCCOC,,,,val
US04649142,COc1ccc(-c2cc(=Nc3c(C)cc(C)cc3C)n(C)c(=O)n2C)cc1OC>>Cc1cc(C)c(N=c2cc(-c3ccc(O)c(O)c3)n(C)c(=O)n2C)c(C)c1,,Br,,[Na+].[OH-],,val
US20090170828A1,COC(=O)c1ccc(Cl)nn1.FC(F)(F)c1ccccc1OC1CNC1>>COC(=O)c1ccc(N2CC(Oc3ccccc3C(F)(F)F)C2)nn1,,CC(C)(C)O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130225524A1,COC(=O)c1cc(Nc2c(C(N)=O)cnc3cc(-c4ccc(OC)nc4OC)ccc23)cc(C(=O)OC)c1>>COc1ccc(-c2ccc3c(Nc4cc(C(=O)O)cc(C(=O)O)c4)c(C(N)=O)cnc3c2)c(OC)n1,,CCO,,[Na+].[OH-],,val
US04478839,C=CCN=C=O.O=c1ncc(Br)c[nH]1>>C=CCNC(=O)n1cc(Br)cnc1=O,,CN(C)C=O,,,,val
US20020120145A1,COc1cc(-c2cccc(Cl)c2)c2cc(C(O)(c3sccc3Cl)c3cncn3C)ccc2n1>>Cn1cncc1C(O)(c1ccc2[nH]c(=O)cc(-c3cccc(Cl)c3)c2c1)c1sccc1Cl,,C1CCOC1,,Cl,,val
US20050113246A1,C1=NCCc2ccccc21.CC#N.ClCCl.FC(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)COCC1CO1.O=S([O-])[O-]>>CCCCC(CC)COCC(CN1CCc2ccccc2C1)OS(=O)(=O)O,,ClCCl,,,,val
US05610144,CC(C)(C)OC(=O)C1CCC(c2ccccc2)N1C(=O)CN.COc1cccc(N=C=O)c1>>COc1cccc(NC(=O)NCC(=O)N2C(C(=O)OC(C)(C)C)CCC2c2ccccc2)c1,,C1CCOC1,,,,val
US05672753,CC(C)(C)C(=O)C(=O)[O-].NO>>CC(C)(C)C(=NO)C(=O)O,,O,,Cl,,val
US06300363B1,CC(=O)Cl.CC1CCCC(C(=O)c2[nH]c3cc(Cl)ccc3c2N)C1>>CC(=O)Nc1c(C(=O)C2CCCC(C)C2)[nH]c2cc(Cl)ccc12,,CCCCCC,CCOC(C)=O,,,val
US20060229294A1,CC(C)(C)OC(=O)N1CCCC(C(=O)NCCNc2nsc3ccccc23)C1>>O=C(NCCNc1nsc2ccccc12)C1CCCNC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080207654A1,CCCc1nc(CC)n(-c2ccc(OC3CCOCC3)nc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCc1nc(CC)n(-c2ccc(OC3CCOCC3)nc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US03983164,CCOC(=O)c1ccc(O)cc1.CN(C)C(OCc1ccccc1)OCc1ccccc1>>CCOC(=O)c1ccc(OCc2ccccc2)cc1,,ClCCCl,,,,val
US05283349,C=C1C[C@@H]2[C@H](/C=C/[C@H](CCCCC)O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]2C1O.CS(=O)(=O)Cl>>C=C1C[C@@H]2[C@H](/C=C/[C@H](CCCCC)O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]2C1OS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20140296204A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc([N+](=O)[O-])cc1CNC(=S)NCc1ccnc2[nH]ccc12>>CC(C)(C)OC(=O)NCc1cc([N+](=O)[O-])ccc1N,,C1CCOC1,O,[K],,val
US04666890,CC(C)COC(=O)Cl.CC(C)OC(C)C.CCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCC.CN1CCOCC1.C[Si](C)(C)C(C(N)=O)[Si](C)(C)C>>C[C@@H](NC(=O)OC(C)(C)C)C(=O)ON1C(=O)CCC1=O,,CCOC(C)=O,ClCCl,CN(C)C=O,,val
US06057311,Cc1cccc(N=C=O)c1.c1ccc(Cn2c3c(c4ccccc42)CCNC3)cc1>>Cc1cccc(NC(=O)N2CCc3c(n(Cc4ccccc4)c4ccccc34)C2)c1,,C1COCCO1,,,,val
US20090203752A1,N.O=C(Cl)c1cccc(-c2noc(-c3ccccc3F)n2)c1>>NC(=O)c1cccc(-c2noc(-c3ccccc3F)n2)c1,,C1CCOC1,,,,val
US20140275071A1,BrCc1ccccn1.COc1ccc(Cn2c(=O)c3[nH]c(Cc4cccc(OC(F)(F)F)c4)nc3n(C)c2=O)cc1>>COc1ccc(Cn2c(=O)c3c(nc(Cc4cccc(OC(F)(F)F)c4)n3Cc3ccccn3)n(C)c2=O)cc1,,CN(C)C=O,,Br,O=C([O-])[O-].[K+].[K+],val
US20150175557A1,CC1(C)C/C(=N/O)CCC1O>>CC1(C)CC(N)CCC1O,[Ni],CO,,ClCCl,,val
US04086350,CN1CCC(Cl)CC1.O=c1c2ccccc2sc2ccc(F)cc12>>CN1CCC(C2(O)c3ccccc3Sc3ccc(F)cc32)CC1,,C1CCOC1,,[Mg],,val
US20050143422A1,Cc1c(C(=O)OC(C)(C)C)oc2cccc(OS(=O)(=O)C(F)(F)F)c12.OB(O)c1ccoc1>>Cc1c(C(=O)OC(C)(C)C)oc2cccc(-c3ccoc3)c12,,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20060074068A1,Fc1c(Cl)nc(C2CC2)nc1Cl.NC1CC1>>Fc1c(Cl)nc(C2CC2)nc1NC1CC1,,CCOCC,,,,val
US20020114770A1,N#Cc1cccc(S(=O)(=O)N[C@H]2CC[C@@H](c3ccc(O)cc3O)CC2)c1.[N-]=[N+]=[N-]>>O=S(=O)(N[C@H]1CC[C@@H](c2ccc(O)cc2O)CC1)c1cccc(-c2nnn[nH]2)c1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20160024096A1,CC(C)(C)C(=O)Nc1ccc(Cl)cn1.CON(C)C(=O)c1ccccc1>>CC(C)(C)C(=O)Nc1ncc(Cl)cc1C(=O)c1ccccc1,,C1CCOC1,,[Li]C(C)(C)C,,val
US04382939,CC(=O)CN1CCc2c(c(=O)oc3cc(C)c([N+](=O)[O-])cc23)C1>>CC(=O)CN1CCc2c(c(=O)oc3cc(C)c(N)cc23)C1,[Ni],CN(C)C=O,,[H][H],,val
US20130123528A1,CC(C)(C)N1C=CN(C(C)(C)C)[SiH]1Cl.CCCN>>CCCN[SiH]1N(C(C)(C)C)C=CN1C(C)(C)C,,CCCCCC,,,,val
US20090076074A1,COCCn1cc(N)cn1.COc1cc2nccc(Oc3ccc(CC(=O)O)cc3)c2cc1OC>>COCCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20140234965A1,COc1ccc(Nc2nc(Cl)nc(NCCO)n2)cc1>>COc1ccc(Nc2ncnc(NCCO)n2)cc1,[Pd],CO,,,,val
US20140256710A1,COc1nccc2c(-c3cc([N+](=O)[O-])ccc3Nc3ccccn3)cn(C)c12>>Cn1cc(-c2cc([N+](=O)[O-])ccc2Nc2ccccn2)c2cc[nH]c(=O)c21,,CO,,Cl,,val
US20150045359A1,CC(C)(C)OC(=O)N1CCOC(c2ccc(-c3cc(-c4ccc(Cl)cc4)[nH]n3)cc2)C1.Cl>>Cl.Clc1ccc(-c2cc(-c3ccc(C4CNCCO4)cc3)n[nH]2)cc1,,C1COCCO1,,,,val
US20120172382A1,CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1cc(F)c(Oc2ccnc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c2-c2cnn(C)c2)cc1F>>CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1cc(F)c(Oc2ccnc(N)c2-c2cnn(C)c2)cc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110034455A1,CCOC(=O)C1(Cc2ccccc2)CCCN(C(=O)c2ccccc2)C1>>O=C(c1ccccc1)N1CCCC(Cc2ccccc2)(C(=O)O)C1,,CCO,,[Na+].[OH-],,val
US20040106599A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(C(N)CO)cc1.COc1ccc(C(=O)Cl)cc1OC>>COc1ccc(C(=O)NC(O)Cc2ccc(C(=O)Nc3ccccc3NC(=O)OC(C)(C)C)cc2)cc1OC,,ClCCl,,CCN(CC)CC,[Cl-].[NH4+],val
US20140221344A1,CC1CCNCC1NC(=O)OC(C)(C)C.O=[N+]([O-])c1cnccc1Cl>>CC1CCN(c2ccncc2[N+](=O)[O-])CC1NC(=O)OC(C)(C)C,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20090137590A1,CC(C)OC(=O)Cl.c1cc(-n2cnnn2)ncc1OCc1cnn(C2CCNCC2)n1>>CC(C)OC(=O)N1CCC(n2ncc(COc3ccc(-n4cnnn4)nc3)n2)CC1,,CCOC(C)=O,,CCN(CC)CC,O,val
US20120135352A1,C1=CC2CC1CC2CCOCCC1CC2C=CC1C2.CCN(CC)CC.Cc1cc(I)ccc1O.O=CO.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Cc1cc(C2CC3CC2CC3CCOCCC2CC3CC2CC3c2ccc(O)c(C)c2)ccc1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20100093788A1,Cc1cc(-c2c(F)cccc2F)cc(N)c1N.O=CC1=NOC2(CCCCC2)C1>>Cc1cc(-c2c(F)cccc2F)cc2nc(C3=NOC4(CCCCC4)C3)[nH]c12,,CN(C)C=O,,O,,val
US20060019940A1,CN(CCS)Cc1ccc(Br)cc1C(O)c1ccccc1.Cc1ccccc1>>CNCc1ccc(Br)cc1CSCCCc1ccccc1,,CCOC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20040122063A1,CC(C)(C)OC(=O)N1CCC(C=C(Br)Br)CC1.COC(=O)Cl>>COC(=O)C#CC1CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,CCOCC,[Li]CCCC,[Cl-].[NH4+],val
US20060183921A1,CCOC(=O)c1c(C=Cc2ccc(C(C)C)cc2Cl)csc1N.O=C1OC(=O)c2ccccc21>>CCOC(=O)c1c(C=Cc2ccc(C(C)C)cc2Cl)csc1N1C(=O)c2ccccc2C1=O,,CC(=O)O,,,,val
US20010053779A1,CCOC(=O)Cc1nc2cc(C(=O)O)ccc2[nH]1.Nc1ccc(CN2C(=O)c3ccccc3C2=O)cc1N>>O=C(O)c1ccc2[nH]c(Cc3nc4cc(CN5C(=O)c6ccccc6C5=O)ccc4[nH]3)nc2c1,,CCO,ClCCl,,,val
US20090018123A1,CCOC(=O)Cl.NC[C@H]1CN(c2ccc(N3CCC(n4ncnn4)CC3)c(F)c2)C(=O)O1>>CCOC(=O)NC[C@H]1CN(c2ccc(N3CCC(n4ncnn4)CC3)c(F)c2)C(=O)O1,,ClCCl,,CCN(CC)CC,,val
US20130053380A1,C=CC[C@@H](N)C(=O)OC.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=CC[C@@H](NC(=O)OC(C)(C)C)C(=O)OC,,ClCCl,,,,val
US20140275172A1,Cc1c(CCC(=O)OC(C)(C)C)ccc(OCc2cc(F)cc3sc(C(F)(F)F)nc23)c1C>>Cc1c(CCC(=O)O)ccc(OCc2cc(F)cc3sc(C(F)(F)F)nc23)c1C,,ClCCl,ClCCl,O=C(O)C(F)(F)F,,val
US20110275622A1,CNC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12>>CNC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c2[nH]c(=O)ccc12,[Pd],CO,,,,val
US20090312381A1,O=C(NNC(=O)c1ccccc1Cl)NC1CC1>>O=c1[nH]nc(-c2ccccc2Cl)n1C1CC1,,[Na+],[OH-],Cl,,val
US20080096860A1,Fc1cccc(CSc2nc(Cl)cc(Cl)n2)c1F.OCCCO>>OCCCOc1cc(Cl)nc(SCc2cccc(F)c2F)n1,,C1CCOC1,,[H-].[Na+],,val
US20090099201A1,CC(C)(C)OC(=O)N1CCC(Nc2ccc(N)cn2)CC1.O=C(O)c1nc(-c2ccccc2)oc1C(F)(F)F>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(NC(=O)c3nc(-c4ccccc4)oc3C(F)(F)F)cn2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US04806685,COc1ccc(C(C(Br)c2ccc(F)cc2)C(F)(F)F)cc1.COc1ccccc1>>COc1ccc(C(c2ccc(F)cc2)C(c2ccc(OC)cc2)C(F)(F)F)cc1,,COc1ccccc1,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20110034481A1,CCI.O=[N+]([O-])c1cc(O)ccc1F>>CCOc1ccc(F)c([N+](=O)[O-])c1,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20110166147A1,CC(=O)C=O.NC(=O)C(N)C(N)=O>>Cc1cnc(O)c(C(N)=O)n1,,O,,Cl,[Na+].[OH-],val
US20100278833A1,CC(C)CN1CCNCC1.C[C@@H](Oc1cc(-n2cnc3cnc(COS(C)(=O)=O)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F>>CC(C)CN1CCN(Cc2cc3c(cn2)ncn3-c2cc(O[C@H](C)c3ccccc3C(F)(F)F)c(C(N)=O)s2)CC1,,ClCCl,,,,val
US06239151B1,CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)CCC(C)O)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1>>CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)CCC(C)O)[C@H](C/C=C/c1ccccc1)C(=O)NO,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120157428A1,BrCCBr.CCOC(=O)Cc1cc(C)no1>>CCOC(=O)C1(c2cc(C)no2)CC1,,Cc1ccccc1,O,[Na+].[OH-],,val
US06069156,CCCc1cc2ccc(C(=O)OC)cc2n1C(=O)OCc1ccccc1>>CCCc1cc2ccc(C(=O)OC)cc2[nH]1,[Pd],CCOC(C)=O,CO,,,val
US20150191419A1,Br.CC(C)(C)OC(=O)CCOC(=O)CCC(=O)CNC(=O)OC(C)(C)C>>Br.NCC(=O)CCC(=O)OCCC(=O)O,,CC(=O)O,,,,val
US20120208798A1,CC(=O)N1c2ccc(Br)cc2[C@H](NC=O)C[C@@H]1C.O=Cc1ccc(B(O)O)cc1>>CC(=O)N1c2ccc(-c3ccc(C=O)cc3)cc2[C@H](NC=O)C[C@@H]1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20160122331A1,COC(=O)c1ccc(C2CC(O[Si](C)(C)C(C)(C)C)=CC(C)(C)O2)cc1>>COC(=O)c1ccc(C2CC(=O)CC(C)(C)O2)cc1,,C1CCOC1,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090137590A1,CCc1cnc(N2CCC(n3ncc(CO)c3C(F)(F)F)CC2)nc1.O=S(Cl)Cl>>CCc1cnc(N2CCC(n3ncc(CCl)c3C(F)(F)F)CC2)nc1,,ClCCl,,,,val
US20100130464A1,Clc1ccc(C2(c3ccc(I)cc3)CCNCC2)cc1.N#C[Cu]>>N#Cc1ccc(C2(c3ccc(Cl)cc3)CCNCC2)cc1,,CCOC(C)=O,CN(C)C=O,,,val
US20120184533A1,NC(=O)c1cccc(NC(=O)C2c3ccccc3CCN2C(=O)OCc2ccccc2)c1N>>NC(=O)c1cccc2[nH]c(C3c4ccccc4CCN3C(=O)OCc3ccccc3)nc12,,CC(=O)O,,,,val
US20150018363A1,CCn1c(C2CC2)nc2ccc(Br)cc21.O=c1cc(OCc2ccc(F)cc2)cc[nH]1>>CCn1c(C2CC2)nc2ccc(-n3ccc(OCc4ccc(F)cc4)cc3=O)cc21,I[Cu]I,CS(C)=O,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US20030191118A1,COC(=O)[C@H](Cc1ccc(-c2ccccc2OC)cc1)NC(=O)c1c(Cl)cccc1Cl>>COC(=O)[C@H](Cc1ccc(-c2ccccc2O)cc1)NC(=O)c1c(Cl)cccc1Cl,,ClCCl,,BrB(Br)Br,,val
US04728651,COc1cccc(C(=O)c2sccc2Br)c1.NN>>COc1cccc(C=NN)c1,,OCCO,,O,,val
US20040209886A1,Cc1c(C(C)(C)O)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12.OO>>Cc1c(O)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12,,ClCCl,,CCOCC,FB(F)F,val
US20080269445A1,C1=Cc2ccccc2C1.ClCc1cccc2ccccc12>>C1=CC(Cc2cccc3ccccc23)c2ccccc21,,CCOCC,,O,[Li]CCCC,val
US04124601,C1CCC(OC2CCCCO2)OC1.CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC(=O)CCCCC(=O)O>>C1CCC(OC2CCCCO2)OC1.CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CC(=O)CCCCC(=O)O,,CC(C)=O,,O=S(=O)(O)O,O=[Cr](=O)=O,val
US20130040931A1,NNc1ccccc1Br.O=C1CCCCC1=CO>>Brc1ccccc1-n1ncc2c1CCCC2,,CCO,,Cl,,val
US04129661,COC(=O)Cl.NC1=NC(c2ccccc2)CN1>>COC(=O)NC1=NC(c2ccccc2)CN1,,CC(C)=O,,Br,O=C([O-])O.[Na+],val
US20140303168A1,CCOC(=O)c1cncc(-c2nnc(O)c3c(-c4ccccc4)cccc23)c1.O=P(Cl)(Cl)Cl>>CCOC(=O)c1cncc(-c2nnc(Cl)c3c(-c4ccccc4)cccc23)c1,,Cc1ccccc1,,CN(C)c1ccccc1,,val
US04035376,CC(C(=O)Cl)c1ccc(C(=O)c2cccs2)cc1.NCCO>>CC(C(=O)NCCO)c1ccc(C(=O)c2cccs2)cc1,,ClC(Cl)Cl,,,,val
US04070466,CCn1ncc2c1ncc1c(=O)[nH]c3cc(C)nn3c12.CI>>CCn1ncc2c1ncc1c(=O)n(C)c3cc(C)nn3c12,,COCCOCCOC,,[H-].[Na+],,val
US20110196002A1,COC(=O)[C@H](NC(=O)c1cc(-c2ccc(N)cc2)no1)C(C)C.O=S(=O)(Cl)c1ccccc1F>>COC(=O)[C@H](NC(=O)c1cc(-c2ccc(NS(=O)(=O)c3ccccc3F)cc2)no1)C(C)C,,ClCCl,,c1ccncc1,,val
US20020156081A1,COCCN1CCNCC1.COc1cc(-c2nn(-c3ccc(C=O)cc3)c3ncnc(N)c23)ccc1NC(=O)c1ccc(C(F)(F)F)cc1F>>COCCN1CCN(Cc2ccc(-n3nc(-c4ccc(NC(=O)c5ccc(C(F)(F)F)cc5F)c(OC)c4)c4c(N)ncnc43)cc2)CC1,,CC(Cl)Cl,,[Na+].[OH-],,val
US20020107278A1,CC(C)(C)OC(=O)N1CCc2[nH]c3c(Cl)c(Cl)ccc3c2CC1.CCOC(=O)CBr>>CCOC(=O)Cn1c2c(c3ccc(Cl)c(Cl)c31)CCN(C(=O)OC(C)(C)C)CC2,,CN(C)C=O,,[H-].[Na+],,val
US20040034218A1,Nc1ccc(C2(c3ccc(Cl)cc3)OCCO2)cc1C(O)c1cccc(Cl)c1.O=C(O)CS>>Nc1ccc(C(=O)c2ccc(Cl)cc2)cc1C(SCC(=O)O)c1cccc(Cl)c1,,Cl,,,,val
US20120022109A1,CNCC(=O)OC(C)(C)C.N#Cc1ccc(CBr)cc1>>CN(CC(=O)OC(C)(C)C)Cc1ccc(C#N)cc1,,CC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20080255092A1,CC(=O)Cl.CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(CSc3ncc[nH]3)c2CC1>>Cl.Clc1ccc2c(c1CSc1ncc[nH]1)CCNCC2,,CCO,,,,val
US20150353738A1,C=CC(=O)OCCO.Oc1ccc(C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>C=CC(=O)OCC(Oc1ccccc1)C(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020173518A1,CC(C)(C)c1ccc(C(=O)Cl)cc1.Cc1ccc(S(=O)(=O)n2cnc3ccc(NC(=O)c4ccccc4NC(=O)c4ccc(C(C)(C)C)cc4)cc32)cc1.Cc1ccc(S(=O)(=O)n2cnc3ccc(NC(=O)c4ccccc4[N+](=O)[O-])cc32)cc1>>CC(C)(C)c1ccc(C(=O)Nc2ccccc2C(=O)Nc2ccc3[nH]cnc3c2)cc1,,C1COCCO1,O,[Li]O,,val
US20150353553A1,BrC(Br)(Br)Br.OC[C@@H]1CC[C@@H](C(F)(F)F)CC1>>FC(F)(F)[C@@H]1CC[C@@H](CBr)CC1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090203750A1,CC(C)(C)OC(=O)NC[C@@H]1C[C@H]1c1ccccc1Br.OB(O)c1ccc(Cl)cc1>>CC(C)(C)OC(=O)NC[C@@H]1C[C@H]1c1ccccc1-c1ccc(Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20070135456A1,C=CCn1c(Cl)nc2c1c(=O)n(CCCC(F)(F)F)c(=O)n2CCCC(F)(F)F>>O=c1c2[nH]c(Cl)nc2n(CCCC(F)(F)F)c(=O)n1CCCC(F)(F)F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,C1COCCN1,,val
US20110076292A1,COC(OC)N(C)C.NC(=O)c1cn2c(n1)-c1cc(Cl)ncc1OCC2>>CN(C)C=NC(=O)c1cn2c(n1)-c1cc(Cl)ncc1OCC2,,Cc1ccccc1,,,,val
US20040077584A1,CC(C)N(CCNC(=O)n1ccnc1)C(C)C.NCCNC(=O)OCc1ccccc1>>CC(C)N(CCNC(=O)NCCNC(=O)OCc1ccccc1)C(C)C,,ClCCl,,CCN(CC)CC,Cl,val
US20050107449A1,COC(=O)CC(NC(=O)c1ccc(Br)cc1)C(C)=O>>COC(=O)Cc1nc(-c2ccc(Br)cc2)oc1C,,CC(=O)OC(C)=O,,O=S(=O)(O)O,,val
US20050147843A1,CCn1c2ccccc2c2ccccc21.O=C1CCC(=O)N1Br>>CCn1c2ccccc2c2cc(Br)ccc21,,CN(C)C=O,,O,,val
US20050137171A1,COP(=O)(Oc1ccc2[nH]ncc2c1)c1ccccc1.II>>COP(=O)(Oc1ccc2[nH]nc(I)c2c1)c1ccccc1,,CN(C)C=O,,[K+].[OH-],,val
US20160168090A1,O=C(NCC1CCC(F)(F)CC1)c1c[nH]c2cccc(Cl)c12.O=C1CCCN1CCO>>O=C(NCC1CCC(F)(F)CC1)c1cn(CCN2CCCC2=O)c2cccc(Cl)c12,,Cc1ccccc1,,CCCCP(=CC#N)(CCCC)CCCC,,val
US04239681,COC[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CCC(=O)[C@@]3(C)CC[C@@H]12>>COC[C@]12CC[C@H](O)C=C1CC[C@H]1[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]12,O,CO,,CC(=O)O,[BH4-].[Na+],val
US05731322,CC(=O)C(=NNc1ccccc1)C(=O)NCc1ccccc1.CCN1CC[C@]2(c3cccc(OC)c3)CC(=O)CC[C@H]2C1>>COc1cccc([C@@]23CCN(C)C[C@H]2Cc2c([nH]c(C(=O)NCc4ccccc4)c2C)C3)c1,[Zn],CC(=O)O,,Cl,,val
US05455348,COC(=O)C[C@@H]1C[C@@H](COc2ccc(-c3ccc(C(=N)N)cn3)cc2)NC1=O.COC(=O)Cl>>COC(=O)C[C@@H]1C[C@@H](COc2ccc(-c3ccc(C(=N)NC(=O)OC)cn3)cc2)NC1=O,,ClCCl,O,Cl,[Na+].[OH-],val
US20080242665A1,CC(C)(C)OC(=O)N1CCNCC1.O=S(=O)(Cl)c1cccc(F)c1>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2cccc(F)c2)CC1,,ClCCl,,CCN(CC)CC,,val
US20100076187A1,N#Cc1ccc(Cl)nn1.NC1CCN(Cc2cc(F)cc(C(F)(F)F)c2)CC1>>N#Cc1ccc(NC2CCN(Cc3cc(F)cc(C(F)(F)F)c3)CC2)nn1,,CC#N,ClCCl,CCN(C(C)C)C(C)C,,val
US05117057,CC(C)(C)NNC(=O)c1ccccc1.O=C(Cl)c1ccco1>>CC(C)(C)N(NC(=O)c1ccccc1)C(=O)c1ccco1,,Cc1ccccc1,,O,[Na+].[OH-],val
US06005116,COCCl.Oc1cc(-c2ccccc2)on1>>COCOc1cc(-c2ccccc2)on1,,CN(C)C=O,,C[O-].[Na+],,val
US04922022,COC(=O)CCCCC(=O)Cl.NCCC1CCCCC1>>O=C(O)CCCCC(=O)NCCC1CCCCC1,,ClCCl,,CCN(CC)CC,,val
US20140221421A1,Cc1nc(-c2ccccc2)c(C(N)Cc2ccccc2)s1.O=C(O)Cn1nc(C(F)(F)F)c2c1CCCC2>>Cc1nc(-c2ccccc2)c([C@H](Cc2ccccc2)NC(=O)Cn2nc(C(F)(F)F)c3c2CCCC3)s1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04975112,CC(C)(C)C=O.Ic1cnccn1>>CC(C)(C)C(O)c1cnccn1,,CCOCC,,[Li]CCCC,[Cl-].[NH4+],val
US20150152063A1,CNN.N#Cc1ccc(C(F)(F)F)cc1F>>Cn1nc(N)c2ccc(C(F)(F)F)cc21,,CC(C)O,,,,val
US20050222225A1,CC(C)(C)[Si](C)(C)C1Oc2ccc(CO)cc2NC1=O.COC(=O)CCl>>COC(=O)CN1C(=O)COc2ccc(CO)cc21,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20100099658A1,CC(C)S(=O)(=O)c1ccccc1N.COc1nc(Cl)nc(Cl)n1>>COc1nc(Cl)nc(Nc2ccccc2S(=O)(=O)C(C)C)n1,,O,,C1CCOC1,CCN(C(C)C)C(C)C,val
US04505853,CC(C)[C@H](NC(=O)[C@H](CC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N(C(=O)OCc1ccccc1)C(=O)OCc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O>>CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O,[Pd],CO,,O=C[O-].[NH4+],,val
US05015661,C#CC1(C)CCc2c(C)c(O)c(C)c(C)c2O1.Oc1cccnc1Br>>Cc1c(C)c2c(c(C)c1O)CCC(C)(c1cc3ncccc3o1)O2,,CCN(CC)CC,,,,val
US20140171438A1,CC(C)(C)OC(=O)N=C(NCCCCC(=O)Nc1cc(C(F)(F)F)cc(NC(=O)Nc2ccc(Oc3cc([NH+]([O-])O)cc(C(F)(F)F)c3)cc2)c1SCCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C>>N=C(N)NCCCCC(=O)Nc1cc(C(F)(F)F)cc(NC(=O)Nc2ccc(Oc3cc([N+](=O)[O-])cc(C(F)(F)F)c3)cc2)c1SCCN,,ClCCl,,O=C(O)C(F)(F)F,,val
US05919753,O=C(O)CCCCCCCCCCCCCCCCCCCCCCC(=O)O.OCc1ccccc1>>O=C(O)CCCCCCCCCCCCCCCCCCCCCCC(=O)OCc1ccccc1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20090312338A1,Br[Mg]C1CCC1.O=Cc1c(Cl)cnc2[nH]ccc12>>OC(c1c(Cl)cnc2[nH]ccc12)C1CCC1,,C1CCOC1,,O,,val
US04167570,Cc1cc(C)c(C(=O)O)c(Cl)n1.Cc1cc(N)c(N)cc1C>>Cc1cc(C)c2c(n1)Nc1cc(C)c(C)cc1NC2=O,,O=S1(=O)CCCC1,,N,,val
US04833164,C#CCCCC(OC)(OC)OC.O=Cc1ccc2ccccc2c1OCc1ccccc1>>COC(=O)CCCC#CC(O)c1ccc2ccccc2c1OCc1ccccc1,,C1CCOC1,CCOCC,O,[Li]CCCC,val
US20160244451A1,COC(=O)[C@H](Cc1ccc(-c2c(C)n(C)c(=O)n(C)c2=O)cc1)NC(=O)OC(C)(C)C>>COC(=O)[C@@H](N)Cc1ccc(-c2c(C)n(C)c(=O)n(C)c2=O)cc1,,ClCCl,,Cl,,val
US05709911,Fc1cccc(C2=CCC(C3CCC4(CC3)OCCO4)CC2)c1F>>Fc1cccc([C@@H]2CC[C@@H](C3CCC4(CC3)OCCO4)CC2)c1F,,C1CCOC1,,,,val
US20050203079A1,O=C1C(c2ccc(Cl)c(Cl)c2)CC(O)N1c1ccc(Cl)c(OCCN2CCCCC2)c1>>O=C1C(c2ccc(Cl)c(Cl)c2)=CCN1c1ccc(Cl)c(OCCN2CCCCC2)c1,,O=C(O)C(F)(F)F,,,,val
US20050288346A1,CCCC(=O)c1ccc(O)c(C)c1O.N#Cc1ccc(OCCCCBr)cc1>>CCCC(=O)c1ccc(OCCCCOc2ccc(C#N)cc2)c(C)c1O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150080588A1,Br[Mg]C1CC1.CC(C)(C)OC(=O)N[C@@H]1C=C[C@](CC=O)(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1>>CC(C)(C)OC(=O)N[C@@H]1C=C[C@](CC(O)C2CC2)(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1,,C1CCOC1,,[Cl-].[NH4+],,val
US20160176854A1,COc1ccc(-c2cn(C(=O)N(C)C3CCN(C(=O)OC(C)(C)C)CC3)cn2)cc1C.Cl>>COc1ccc(-c2cn(C(=O)N(C)C3CCNCC3)cn2)cc1C.Cl,,CCOCC,,O=C(O)C(F)(F)F,,val
US20110213109A1,COC1c2cccc(CBr)c2CC1C>>CC1=Cc2cccc(CBr)c2C1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20160102081A1,CC(C)(C)[Si](C)(C)OCCCBr.Ic1cncc(-c2nn[nH]n2)c1>>CC(C)(C)[Si](C)(C)OCCCn1nnc(-c2cncc(I)c2)n1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20100256386A1,Cc1ccc(B2OBOBO2)c(C)c1.FC(F)(F)c1nc[nH]n1>>Cc1ccc(-n2cnc(C(F)(F)F)n2)c(C)c1,[Cu],CCOC(C)=O,CN(C)C=O,Cl,c1ccncc1,val
US04417050,COc1ccc(CO)cc1-c1ncccn1.FC(F)(F)c1cccc(CCl)c1>>COc1ccc(COCc2cccc(C(F)(F)F)c2)cc1-c1ncccn1,,O,,C1CCOC1,[H-].[Na+],val
US20100008863A1,C=CCOC(=O)OC(=O)OCC=C.Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](N)C(=O)O)c(C)c2c1OC(C)(C)CC2>>C=CCOC(=O)N[C@@H](CCCNC(=N)NS(=O)(=O)c1c(C)c(C)c2c(c1C)CCC(C)(C)O2)C(=O)O,,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20110301142A1,CCOC(=O)Cc1ccccc1Br.Cc1noc(-c2cccc(B3OC(C)(C)C(C)(C)O3)c2)c1NC(=O)OC(C)c1ccccc1Cl>>CCOC(=O)Cc1ccccc1-c1cccc(-c2onc(C)c2NC(=O)OC(C)c2ccccc2Cl)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,O,O=C([O-])O.[Na+],,val
US20090306043A1,CC(=O)/C=C/c1ccc(C#N)cc1.COCN(Cc1ccccc1)C[Si](C)(C)C>>CC(=O)C1CN(Cc2ccccc2)CC1c1ccc(C#N)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100179126A1,COc1ncc(Br)cc1CCC(=O)N(C)C>>COc1ncc(Br)cc1CCCN(C)C,,C1CCOC1,,B,,val
US20120010244A1,COCCCl.O=S([O-])[O-].[Na+]>>COCCS(=O)(=O)[O-].[Na+],,COCCOC,,O,,val
US20130345438A1,C[N+](=O)[O-].O=C1C(=O)N(Cc2ccccc2Cl)c2ccccc21>>O=C1N(Cc2ccccc2Cl)c2ccccc2C1(O)C[N+](=O)[O-],,O,,,,val
US20140045746A1,BrP(Br)Br.Cc1cc(OCCCS(C)(=O)=O)ncc1-c1ccc(F)c(CO)c1>>Cc1cc(OCCCS(C)(=O)=O)ncc1-c1ccc(F)c(CBr)c1,,C1CCOC1,,,,val
US05552409,CCC#CCBr.CCCCCC.CN(C)C=O.O=c1cccc[nH]1.[Cl-].[NH4+]>>CCC#CCn1cc(-c2ccc(Cl)cc2)cnc1=O,,CN(C)C=O,,[H-].[Na+],,val
US20020161036A1,C#CCOc1ccc2c(C)cc(=O)oc2c1C(C)=O.COc1cccc(C=O)c1>>C#CCOc1ccc2c(C)cc(=O)oc2c1C(=O)C=Cc1cccc(OC)c1,,CCO,O,[K+].[OH-],,val
US04746352,CCOC(=O)C=C(C)NC(=S)Nc1ccc(Cl)c(C(=O)OC(C)C)c1>>Cc1cc(=O)n(-c2ccc(Cl)c(C(=O)OC(C)C)c2)c(=S)[nH]1,,CC(C)O,,[Na],,val
US04316839,CN1Cc2c(C=NO)ncn2-c2ccccc2C1=O>>CN1Cc2c(C#N)ncn2-c2ccccc2C1=O,,CC(=O)OC(C)=O,,,,val
US04730008,CCCCC(=O)OC(=O)CCCC.NCc1ccc(I)cc1>>CCCCC(=O)NCc1ccc(I)cc1,,c1ccncc1,,,,val
US05026856,CC(=O)NCc1ccc2c(c1)CNC2.CCOC(=O)c1cn(C2CC2)c2nc(Cl)c(F)cc2c1=O>>CCOC(=O)c1cn(C2CC2)c2nc(N3Cc4ccc(CNC(C)=O)cc4C3)c(F)cc2c1=O,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20080312270A1,COC(=O)Cc1ccc(O)c(OC)c1.C[Si](C)(C)CCOCn1ncc2c([N+](=O)[O-])c(Cl)ccc21>>COC(=O)Cc1ccc(Oc2ccc3c(cnn3COCC[Si](C)(C)C)c2[N+](=O)[O-])c(OC)c1,,C1CCOC1,,[Na],,val
US20150038437A1,COC(=O)Cl.Nc1ccc(Br)cc1I>>COC(=O)Nc1ccc(Br)cc1I,,O,c1ccncc1,,,val
US20080312226A1,Br.N#CSCC(=O)c1ccc(F)cc1>>Fc1ccc(-c2csc(Br)n2)cc1,,CC(=O)O,,O,,val
US20160221938A1,Cc1cc(Cl)sc1Cl.O=S(=O)(O)Cl>>Cc1c(Cl)sc(Cl)c1S(=O)(=O)Cl,,ClCCl,,,,val
US20130143907A1,COc1ncc(C)c(-c2ccc(-c3c(C(=O)O)cnn3[C@H]3CCOC3)c(F)c2)c1C.N>>COc1ncc(C)c(-c2ccc(-c3c(C(N)=O)cnn3[C@H]3CCOC3)c(F)c2)c1C,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20020037856A1,CN(C)CCNC(=O)c1cc2ccc([N+](=O)[O-])cc2[nH]1>>CN(C)CCNC(=O)c1cc2ccc(N)cc2[nH]1,[Pd],CCO,CCOC(C)=O,,,val
US20050113580A1,O=Cc1ccc(O)cc1.OCCCN(CC(c1ccccc1)c1ccccc1)C(Cl)(c1ccccc1)C(F)(F)F>>O=Cc1ccc(OCCCN(CC(c2ccccc2)c2ccccc2)C(Cl)(c2ccccc2)C(F)(F)F)cc1,,Cc1ccccc1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040082780A1,FC(F)(F)c1ccc(-c2cc(Cl)ncn2)cc1.O=c1ccc2ccc(O)cc2[nH]1>>O=c1ccc2ccc(Oc3cc(-c4ccc(C(F)(F)F)cc4)ncn3)cc2[nH]1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20110263564A1,[N-]=[N+]=NC1CCCc2ccc(-c3cccc(C(F)(F)F)c3)nc21>>NC1CCCc2ccc(-c3cccc(C(F)(F)F)c3)nc21,[Pd],CO,,[H][H],,val
US20070105820A1,O=C(Cl)c1ccc(Cl)cc1.O=C1Nc2ccccc2C1=O>>O=C1C(=O)N(C(=O)c2ccc(Cl)cc2)c2ccccc21,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110021520A1,CC(C)(C)OC(=O)NC1=NC(C)(c2cccc(NC(=O)c3ccco3)c2)COC1.Cl>>CC1(c2cccc(NC(=O)c3ccco3)c2)COCC(N)=N1.Cl,,ClCCl,,C1COCCO1,,val
US04581356,CC1NC(=O)NN=C1c1ccc2c(c1)CCCN2.O=C(Cl)C1CC1>>CC1NC(=O)NN=C1c1ccc2c(c1)CCCN2C(=O)C1CC1,,CN(C)C=O,,CCN(CC)CC,,val
US20150152047A1,CCS(=O)(=O)c1ccc(Cl)cc1NNC(=O)c1ccc(NC2CCN(C(=O)OC(C)(C)C)CC2)c(OC)c1.ClCCl>>CCS(=O)(=O)c1ccc(Cl)cc1NNC(=O)c1ccc(NC2CCNCC2)c(OC)c1.Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US03992441,C1CSCCN1.O=C(O)c1cc(S(=O)(=O)Cl)ccc1Br>>O=C(O)c1cc(S(=O)(=O)N2CCSCC2)ccc1Br,,ClCCl,,,,val
US05801170,CN(C)CCCl.COc1ccccc1N>>COc1ccccc1NCCN(C)C,,CCO,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20030069284A1,COc1cc(CBr)ccc1[N+](=O)[O-].NCc1ccccc1>>COc1cc(CNCc2ccccc2)ccc1[N+](=O)[O-],,C1CCOC1,,CCN(CC)CC,,val
US20140142083A1,CN(c1cc(Cl)nc(C(=O)O)c1Cl)C1CCOCC1.Cc1cc(C)c(CN)c(=O)[nH]1>>Cc1cc(C)c(CNC(=O)c2nc(Cl)cc(N(C)C3CCOCC3)c2Cl)c(=O)[nH]1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130029987A1,CC(C)(C)Nc1nc(S(C)(=O)=O)ncc1C(N)=O.NC12CCC(O)(CC1)C2>>CC(C)(C)Nc1nc(NC23CCC(O)(CC2)C3)ncc1C(N)=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20100190763A1,CC(C)(C)OC(=O)N1CCN(c2cc(F)c(C#N)cc2F)CC1.O.[OH-]>>CC(C)(C)OC(=O)N1CCN(c2cc(F)c(C(=O)O)cc2F)CC1,,CCO,,Cl,,val
US20040176361A1,CN1CCNCC1.Cc1cccc2c(=O)[nH]c(Cl)cc12>>Cc1cccc2c(=O)[nH]c(N3CCN(C)CC3)cc12,,ClC(Cl)Cl,,,,val
US20030149004A1,CCOC(=O)C1CCN(C)CC1>>CN1CCC(C(=O)O)CC1,,CCO,,[Na+].[OH-],,val
US20050014942A1,CCOC(=O)c1c(-c2ccccc2)n(C)c2cccnc12>>Cn1c(-c2ccccc2)c(C(=O)O)c2ncccc21,,CCO,,[K+].[OH-],,val
US20090281131A1,COC(Cl)Cl.COc1cccc2c1oc1ccccc12>>COc1ccc(C=O)c2c1oc1ccccc12,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20060074071A1,CC(C)(C)OC(=O)N1[C@H](CN)C[C@@H]2CCCC[C@@H]21.O=Cc1cc2ccccc2s1>>CC(C)(C)OC(=O)N1[C@H](CNCc2cc3ccccc3s2)C[C@@H]2CCCC[C@@H]21,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070244132A1,CC#Cc1ncnc(Oc2ccccc2)c1N>>Cc1cc2ncnc(Oc3ccccc3)c2[nH]1,,C1CCOC1,,O,CC(C)(C)[O-].[K+],val
US20040077726A1,NO.O=C(Cl)C=Cc1cccc(S(=O)(=O)NCc2ccc3c(c2)OCO3)c1>>O=C(C=Cc1cccc(S(=O)(=O)NCc2ccc3c(c2)OCO3)c1)NO,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20040116694A1,COc1c([N+](=O)[O-])ccc(C=O)c1O>>O=Cc1ccc([N+](=O)[O-])c(O)c1O,,ClCCl,,BrB(Br)Br,,val
US20100135954A1,CC(=O)Nc1ccc(C(C)=O)c(C)c1.Cc1cc(C=O)ccc1O>>CC(=O)Nc1ccc(C(=O)/C=C/c2ccc(O)c(C)c2)c(C)c1,,CCO,O,Cl,[Na+].[OH-],val
US20160158207A1,CNC(C)CO.N#Cc1cc([N+](=O)[O-])c(F)cc1Br>>CC(CO)N(C)c1cc(Br)c(C#N)cc1[N+](=O)[O-],,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US04443448,O=C(O)CC(c1ccc(F)cc1)c1ccc(F)cc1>>O=C1CC(c2ccc(F)cc2)c2ccc(F)cc21,,O=S(Cl)Cl,,,,val
US05516788,COc1cc(C)c2c(c1)-c1c([nH]c3ccccc13)C2>>COc1cc(C)c2c(c1)[C@@H]1c3ccccc3N[C@@H]1C2,,CC(=O)O,O,[Na+].[OH-],,val
US20060116383A1,CCOC(=O)CC(c1ccccc1)n1cnc2cc(N)ccc21.O=C(Cl)c1cccc([N+](=O)[O-])c1>>CCOC(=O)CC(c1ccccc1)n1cnc2cc(NC(=O)c3cccc([N+](=O)[O-])c3)ccc21,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US04286089,CC(C)(C)OC(=O)C1=C(C(CCC(N)=O)Sc2nnn[nH]2)CS[C@@H]2C(N)C(=O)N12.O=C(O)CS(=O)(=O)CC(F)(F)F>>CC(C)(C)OC(=O)C1=C(C(CCC(N)=O)Sc2nnn[nH]2)CS[C@@H]2C(NC(=O)CS(=O)(=O)CC(F)(F)F)C(=O)N12,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150018341A1,CCC(=C(c1ccc(O)cc1)c1ccc(OCCCl)cc1)c1ccc(O)c(F)c1.CN>>CC/C(=C(\c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccc(O)c(F)c1,,CO,,,,val
US20060142265A1,CCc1c(C(=O)NC)[nH]c2ccccc12>>CCc1c(CNC)[nH]c2ccccc12,,C1COCCO1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090099187A1,COc1ccc(S(=O)(=O)Cl)c2c1C[C@@H](N(C)C(=O)C(F)(F)F)CC2.c1cnc2[nH]ccc2c1>>COc1ccc(S(=O)(=O)n2ccc3cccnc32)c2c1C[C@@H](N(C)C(=O)C(F)(F)F)CC2,,CN(C)C=O,,O,[H-].[Na+],val
US20120323006A1,COC(=O)[C@H](CNC(=O)OC(C)(C)C)N1CCN(C(=O)C(C)C)CC1>>CC(C)C(=O)N1CCN([C@@H](CNC(=O)OC(C)(C)C)C(=O)O)CC1,,C1CCOC1,O,CC(=O)O,[Li+].[OH-],val
US20120010183A1,CC(F)(F)Oc1cc(Oc2cc(F)c(C(=O)O)cc2Cl)cnc1C1CC1.CS(N)(=O)=O.ClCCl>>CC(F)(F)Oc1cc(Oc2cc(F)c(C(=O)NS(C)(=O)=O)cc2Cl)cnc1C1CC1.Cl,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120035237A1,BrCC1CC1.O=C(Nc1c(F)cccc1F)c1ccn(Cc2cc(Cl)ccc2O)n1>>O=C(Nc1c(F)cccc1F)c1ccn(Cc2cc(Cl)ccc2OCC2CC2)n1,,CN(C)C=O,CO,O=C([O-])[O-].[K+].[K+],,val
US20120238579A1,COC(=O)c1ccc(C(=O)O)nc1.NC1CCOCC1>>COC(=O)c1ccc(C(=O)NC2CCOCC2)nc1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20040082607A1,CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)C)c(=O)c2ccc(C(N)=NO)cc12.O=C(n1ccnc1)n1ccnc1>>CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)C)c(=O)c2ccc(-c3noc(=O)[nH]3)cc12,,CCOC(C)=O,,O,,val
US20040009965A1,CC(=O)Cl.Cc1cc2ccc(O)cc2s1>>CC(=O)Oc1ccc2cc(C)sc2c1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20100137318A1,CCC(C)(C)C(C=O)CC(C)=O.NN1C(=O)c2ccccc2C1=O>>CCC(C)(C)c1cc(C)n(N2C(=O)c3ccccc3C2=O)c1,Cl,CCOC(C)=O,,C1CCOC1,,val
US20060106096A1,Cl.Nc1ccc2cc(C(=O)N[C@H]3CN4CCC3CC4)sc2c1.O=C=NC1CCCCC1>>Cl.O=C(Nc1ccc2cc(C(=O)N[C@H]3CN4CCC3CC4)sc2c1)NC1CCCCC1,,C1CCOC1,CN(C)C=O,CCN(CC)CC,Cl,val
US20130158057A1,CNc1nc(Nc2cc(OC)c(C(=O)NNC(C)=O)cc2Cl)ncc1C(F)(F)F>>CNc1nc(Nc2cc(OC)c(-c3nnc(C)o3)cc2Cl)ncc1C(F)(F)F,,C1CCOC1,,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US20100010007A1,NC1CCN(C(=O)OCc2ccccc2)CC1.O=C=NCCCl>>O=C(OCc1ccccc1)N1CCC(N2CCNC2=O)CC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20080139631A1,O=Cc1cc2cc(OCc3ccccc3)ccc2n1S(=O)(=O)c1ccccc1.O=S(=O)(Cl)Cl>>O=Cc1cc2c(Cl)c(OCc3ccccc3)ccc2n1S(=O)(=O)c1ccccc1,,CC(=O)O,ClCCl,,,val
US20130231313A1,CC(C)(NC(=O)C(NC(=O)Cn1nc(-c2ccc(Cl)cc2)n(/C=C/C(F)(F)F)c1=O)c1ccccc1C(F)(F)F)C(N)=O>>CC(C)(NC(=O)C(NC(=O)Cn1nc(-c2ccc(Cl)cc2)n(CCC(F)(F)F)c1=O)c1ccccc1C(F)(F)F)C(N)=O,[Pt],CO,,,,val
US20110281838A1,Cc1nc(N)nc(N2CCCC(NC(=O)OC(C)(C)C)C2)c1C#Cc1ccc(N)nc1>>Cc1nc(N)nc(N2CCCC(N)C2)c1C#Cc1ccc(N)nc1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20080227770A1,COc1cccc([C@H]2O[C@H](CC(C#N)O[Si](C)(C)C(C)(C)C)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC.NO>>COc1cccc([C@H]2O[C@H](CC(O[Si](C)(C)C(C)(C)C)/C(N)=N/O)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC,,CCOC(C)=O,CS(C)=O,CCN(CC)CC,Cl,val
US05446152,CCN(CC)CCCN.O=c1[nH]c2ccc(Cl)cc2c(=O)o1>>CCN(CC)CCCNC(=O)c1cc(Cl)ccc1N,,C1COCCO1,,,,val
US08741932B2,COc1ncc(B(O)O)c(OC)n1.O=Cc1cnc2ccc(Br)cn12>>COc1ncc(-c2ccc3ncc(C=O)n3c2)c(OC)n1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20160102083A1,COC(=O)c1csc(Br)c1C>>Cc1c(C(=O)O)csc1Br,,CO,,[Na+].[OH-],,val
US20120020884A1,BrBr.CCN(CC)C(=O)C1CC(C)CCC1=O>>CCN(CC)C(=O)C1=C(O)C(Br)CC(C)C1,,CCOCC,,,,val
US20020147192A1,O=S(=O)(Nc1ccccc1)c1cccc(CO)c1>>O=Cc1cccc(S(=O)(=O)Nc2ccccc2)c1,O=[Mn]=O,ClCCl,,,,val
US20100256143A1,Clc1cc(N2CCOCC2)nc(CBr)n1.NCCc1ccccc1>>Clc1cc(N2CCOCC2)nc(CNCCc2ccccc2)n1,,CC#N,,[Cl-].[NH4+],,val
US20120122888A1,N#CCC#N.O=Cc1ccc(F)cc1>>N#CC(C#N)Cc1ccc(F)cc1,,CCO,O,Cl,[BH4-].[Na+],val
US20050282819A1,CC1(C)C(=O)C(C)(C)c2cc(CCN3CCN(c4noc5ccccc45)CC3)ccc21.CS(=O)(=O)O>>CC1(C)C(=O)C(C)(C)c2cc(CCN3CCN(c4noc5ccccc45)CC3)ccc21.CS(=O)(=O)O,,CCOC(C)=O,,,,val
US04256898,CC(C)(C)OC(=O)ON=C(C#N)c1ccccc1.NO[C@H]1CC=C[C@H]1NC(=O)OCC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)NO[C@H]1CC=C[C@H]1NC(=O)OCC(Cl)(Cl)Cl,,C1CCOC1,,,,val
US20070004675A1,CN(CCn1cnc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)c1)C(=O)OC(C)(C)C>>CN(CCn1cnc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)c1)C(=O)OC(C)(C)C,[Fe],CCO,O,[Cl-].[NH4+],,val
US20050215555A1,BrCCc1ccccc1.Cc1ccn2c(C3CCNCC3)nc(-c3ccccc3)c2c1>>Cc1ccn2c(C3CCN(CCc4ccccc4)CC3)nc(-c3ccccc3)c2c1,,CC#N,CO,CCN(C(C)C)C(C)C,,val
US20100093730A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1NCCNC1c1ccccc1>>CC(C)(C)OC(=O)N1CCNC(=O)C1c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20080306086A1,COC(=O)C1CC(N=[N+]=[N-])CN1Cc1ccccc1>>COC(=O)C1CC(N)CN1Cc1ccccc1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05440044,CCCCCCCCC(/C=C/c1cccc(Br)n1)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.CN(C)C=O>>CCCCCCCCC(/C=C/c1cccc(C=O)n1)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,C1CCOC1,CCOCC,Cl,[Li]CCCC,val
US20150148337A1,Cc1noc2c1-c1ccc(-c3cnn(C)c3)cc1C(=O)N(C(=O)OC(C)(C)C)[C@H]2CC(=O)OC(C)(C)C.Clc1ccc([Mg]Br)cc1>>Cc1noc([C@H](CC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)c1-c1ccc(-c2cnn(C)c2)cc1C(=O)c1ccc(Cl)cc1,,C1CCOC1,,CCOC(C)=O,Cl,val
US20120135316A1,Cc1nccn1C.FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CCCI>>Cc1n(C)cc[n+]1CCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.[I-],,Cc1ccccc1,,,,val
US20010027196A1,N#Cc1c(OS(=O)(=O)C(F)(F)F)nc(N)nc1C1=CCCO1.NCCNc1ccccc1>>N#Cc1c(NCCNc2ccccc2)nc(N)nc1C1=CCCO1,,COCCOC,,,,val
US20070161665A1,CCN.CCOc1ccncc1[N+](=O)[O-]>>CCNc1ccncc1[N+](=O)[O-],,CCO,,,,val
US20060122250A1,Cc1cccc(C)c1N.Cl.ClI>>Cc1cc(I)cc(C)c1N.Cl,,CO,,O=C([O-])O.[Na+],,val
US20100048940A1,CCC(C)=O.OCC(O)CO>>CCC(C)=O.OCC(O)CO,[Pd],,,,,val
US20030144263A1,CC(C)(C)[Si](C)(C)OC1CN(c2ccc(N3C[C@H](COc4ccon4)OC3=O)cc2F)C1>>O=C1O[C@@H](COc2ccon2)CN1c1ccc(N2CC(O)C2)c(F)c1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20020035102A1,CC(=O)OC(C)=O.O=S(=O)(C=C1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1)Cc1cccc(N2CCNCC2)c1>>CC(=O)N1CCN(c2cccc(CS(=O)(=O)C=C3CN(C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)C3)c2)CC1,,CCOC(C)=O,O,c1ccncc1,,val
US20130131016A1,C=C(c1cc(Cl)c(Cl)c(Cl)c1)C(F)(F)F.CC1(C)OB(O)c2ccc(C(Cl)=NO)cc21>>CC1(C)OB(O)c2ccc(C3=NOC(c4cc(Cl)c(Cl)c(Cl)c4)(C(F)(F)F)C3)cc21,,CN(C)C=O,,,,val
US20090029976A1,CCOC(=O)COc1ccc(OC)cc1C=O>>CCOC(=O)c1cc2cc(OC)ccc2o1,,COCCOC,,CC(C)(C)[O-].[K+],,val
US05830915,COC(=O)[C@@H](CC(C)C)NCc1cccnc1.CP(=O)(Cl)c1ccccc1>>COC(=O)[C@@H](CC(C)C)N(Cc1cccnc1)P(C)(=O)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CN1CCOCC1,,val
US20140171403A1,C=CC(=O)OC.Clc1cc(Cl)cc(I)c1>>COC(=O)/C=C/c1cc(Cl)cc(Cl)c1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20040006093A1,COC(=O)[C@@H](N)C(C)C.Cc1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)O)cc1>>Cc1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)O)C(C)C)cc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20080280869A1,COC(=O)c1ccc(-n2nc(-c3cccc(C#N)c3)oc2=O)cc1>>N#Cc1cccc(-c2nn(-c3ccc(C(=O)O)cc3)c(=O)o2)c1,,ClCCl,,BrB(Br)Br,,val
US05646173,C[C@@H](O)CN.O=CCC1Cc2ccc(-c3ccccc3)cc2C1=O>>C[C@@H](O)Cn1ccc2c1-c1cc(-c3ccccc3)ccc1C2,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,O,,val
US20040186118A1,NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br.O=C=Nc1ccccc1>>O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br)Nc1ccccc1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US04616086,CCCCO.CCCCOC(=O)C=Cc1ccc([N+](=O)[O-])cc1.CCCCOC(=O)CCc1ccc(N)cc1>>CCCCOC(=O)CCc1ccc(N2CCNCC2)cc1,[Pd],,,O=C([O-])[O-].[K+].[K+],,val
US04505922,C#C.CC(C)(C)C(=O)C(Oc1ccc(F)cc1)n1cncn1>>C#CC(O)(C(Oc1ccc(F)cc1)n1cncn1)C(C)(C)C,,C1CCOC1,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20070197621A1,CCc1cccc(CC)c1C(O)c1ncc[nH]1>>CCc1cccc(CC)c1Cc1ncc[nH]1,[Zn],Cl,,[Na+].[OH-],,val
US20050250753A1,BrCc1ccccc1Br.N#Cc1cc(Cl)ccc1O>>N#Cc1cc(Cl)ccc1OCc1ccccc1Br,,CN(C)C=O,,[H-].[Na+],,val
US05326776,CCOC(=O)c1cnc(N)s1.Cl>>CCOC(=O)c1cnc(Cl)s1,,CC#N,,CC(C)(C)ON=O,,val
US20080242698A1,CCOC(=O)CNC(c1ccccc1)c1ccccc1>>O=C(O)CNC(c1ccccc1)c1ccccc1,,[K+],[OH-],CO,,val
US20140288040A1,CCC(N)c1ccc(F)c(Oc2ccccc2)c1F.COCCBr.Cl>>CCC(NCCOC)c1ccc(F)c(Oc2ccccc2)c1F.Cl,,C1CCOC1,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US03962249,C[C@@H]1CN(CCCc2ccccc2)[C@@H](C)CN1.Cc1occc1C(=O)Cl>>Cc1occc1C(=O)N1C[C@H](C)N(CCCc2ccccc2)C[C@H]1C.Cl,,c1ccccc1,,,,val
US20130131043A1,CC(C)(C)OC(=O)N1CCCC(COS(C)(=O)=O)C1.Clc1ncc2cn[nH]c2n1>>CC(C)(C)OC(=O)N1CCCC(Cn2ncc3cnc(Cl)nc32)C1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05446161,CC(C)(C)N1CCC[C@H]1C(=O)NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)N1CCC[C@H]1C(=O)[NH+]([O-])C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1,,ClCCl,,,,val
US20150045378A1,CCOC(=O)CC(c1cc(OCc2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)n2)ncc1F)C1CC1>>COc1ccc(F)c(-c2ccc(COc3cc(C(CC(=O)O)C4CC4)c(F)cn3)nc2CC(C)(C)C)c1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20050148627A1,CB1OB(C)OB(C)O1.CCOC(=O)C1=Cc2cc(Cl)c(NCC(C)C)cc2OC1C(F)(F)F>>CCOC(=O)C1=Cc2cc(C)c(NCC(C)C)cc2OC1C(F)(F)F,,COCCOCCOC,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110028467A1,COc1c(Br)cc(C(=O)Cl)cc1Br.FC(F)(F)c1ccccc1-c1cnc2c(c1)NCCO2>>COc1c(Br)cc(C(=O)N2CCOc3ncc(-c4ccccc4C(F)(F)F)cc32)cc1Br,,ClCCl,,CCN(CC)CC,O,val
US04122193,CC(C)NC(=O)NC(C)C.CC12CC3CC(C)(C1)CC(Br)(C3)C2.Cl>>CC(C)N(C)C12CC3CC(C)(CC(C)(C3)C1)C2.Cl,,O,,,,val
US20110230458A1,CCCCc1nnc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1-c1ccc(OC2CCCCC2)c(-c2cnn(CCOC)c2)c1.Cl.ClCCl>>CCCCc1nnc(OC2CCNCC2)cc1-c1ccc(OC2CCCCC2)c(-c2cnn(CCOC)c2)c1.Cl.Cl,,C1COCCO1,ClCCl,,,val
US20050124692A1,[N-]=[N+]=NCC1Cc2c(Cl)cc3c(c2O1)CCC3>>NCC1Cc2c(Cl)cc3c(c2O1)CCC3,[Pt],,,Cl,,val
US05639752,CC#N.CN1CCC[C@@H]1Cc1c[nH]c2ccccc12.O=[N+]([O-])c1cccnc1Cl>>CN1CCC[C@@H]1Cc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12,,CC#N,,CCN(CC)CC,,val
US04210648,CCN1CCCC(N)C1.O=C1Nc2cccnc2N(C(=O)CCl)c2ccccc21>>CCN1CCCC(NCC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20080255239A1,CON=C1CCc2cccnc21>>NC1CCc2cccnc21,[Pd],O=C(O)C(F)(F)F,,,,val
US20130150339A1,CC(=O)O.CC1(C)C(=O)N(Cl)C(=O)N1Cl.COc1cc(C(F)F)ccc1-c1nc(C)nc2cc(SCc3ccccc3)ccc12.O>>COc1cc(C(F)F)ccc1-c1nc(C)nc2cc(S(=O)(=O)Cl)ccc12,,ClCCl,,O,,val
US05958957,N#CN=C(Oc1ccccc1)Oc1ccccc1.NNC(=O)c1ccc2ccccc2c1>>N#CNC1NN=C(c2ccc3ccccc3c2)O1,,CC(C)O,,CCN(CC)CC,,val
US20130217664A1,CC(C)S(=O)(=O)Cl.CCc1cc(C2CNC2)ncc1N(C)c1cc2c(cn1)ncn2C>>CCc1cc(C2CN(S(=O)(=O)C(C)C)C2)ncc1N(C)c1cc2c(cn1)ncn2C,,ClCCl,O,c1ccncc1,,val
US20140274696A1,COC(=O)c1nc(-c2cc(F)c([Si](C)(C)C)cc2F)c(F)c(N)c1Cl.ClI>>COC(=O)c1nc(-c2cc(F)c(I)cc2F)c(F)c(N)c1Cl,,ClCCl,,O=S([O-])[O-].[Na+].[Na+],,val
US20140283218A1,CC(=O)c1sc(-c2cccnc2)nc1Cl.NO>>CC(=NO)c1sc(-c2cccnc2)nc1Cl,,CO,c1ccncc1,Cl,,val
US20050038035A1,O=C(NCCc1ccccn1)c1ccc([N+](=O)[O-])cc1>>Nc1ccc(C(=O)NCCc2ccccn2)cc1,[Pd],C1CCOC1,CO,[H][H],,val
US05614639,COc1ccc2ccsc2c1.II>>COc1ccc2cc(I)sc2c1,,C1CCOC1,,[Li]CCCC,,val
US20150018547A1,CCOC(=O)Cc1csc2cc(/C=C\c3ccc(C)nc3C)ccc12>>CCOC(=O)Cc1csc2cc(CCc3ccc(C)nc3C)ccc12,[Pd],C1CCOC1,,,,val
US20030078248A1,CNC(=O)c1cc(C)c(C)s1.O=C(Cl)c1ccccc1>>CNC(=O)c1sc(C)c(C)c1C(=O)c1ccccc1,,C1CCOC1,,[Li]C(C)(C)C,,val
US20140329794A1,CC(=O)Nc1ccc(C(=O)O)cc1.NCC(O)CN1CCc2ccccc2C1>>CC(=O)Nc1ccc(C(=O)NCC(O)CN2CCc3ccccc3C2)cc1,,ClCCl,O,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20090239810A1,CC(C)(C)OC(=O)NCC(=O)N1CCC(Nc2ccccc2Cl)CC1.Cl>>Cl.NCC(=O)N1CCC(Nc2ccccc2Cl)CC1,,CO,,C1COCCO1,,val
US20130259830A1,CCOC(=O)CBr.Cc1[nH]c2c(c1Cc1cccnc1S(=O)(=O)c1ccccc1)C(=O)CC(C)(C)C2>>CCOC(=O)Cn1c(C)c(Cc2cccnc2S(=O)(=O)c2ccccc2)c2c1CC(C)(C)CC2=O,,CC#N,O,[I-].[K+],,val
US20030166616A1,CN1C(=O)CN(C(=O)OC(C)(C)C)[C@@H](c2ccccc2)[C@H]1COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl>>CN1C(=O)CN[C@@H](c2ccccc2)[C@H]1COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl,,C1COCCO1,,,,val
US20100004280A1,CCC(C)(C)Cc1cn(S(=O)(=O)N(C)C)c(C(O)Cc2ccc(Br)cc2)n1.CCN(CC)S(F)(F)F>>CCC(C)(C)Cc1cn(S(=O)(=O)N(C)C)c(C(F)Cc2ccc(Br)cc2)n1,,ClCCl,,,,val
US20050192300A1,C1COCCN1.Cc1nc(NC(=O)CCBr)sc1-c1ccnc(Nc2ccc(F)cc2)n1>>Cc1nc(NC(=O)CCN2CCOCC2)sc1-c1ccnc(Nc2ccc(F)cc2)n1,,CN(C)C=O,,,,val
US20120077799A1,CC(C)(C)CI.O=S1(=O)CCN2C=CC=C(c3ccc(O)cc3)C2=N1>>CC(C)(C)COc1ccc(C2=CC=CN3CCS(=O)(=O)N=C23)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080207654A1,CCCc1nc(C)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.Cn1nc(CO)c2ccccc21>>CCCc1nc(C)n(Cc2nn(C)c3ccccc23)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20070219230A1,O=[N+]([O-])c1ccc(Cl)nc1Cl.c1ccc2c(c1)CCNC2>>O=[N+]([O-])c1ccc(Cl)nc1N1CCc2ccccc2C1,,O,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20080214616A1,CC(C)(C)NC(=O)c1ccc(C(F)(F)F)nc1C[C@H](O)[C@@H](Cc1cc(F)ccc1F)N(Cc1ccccc1)Cc1ccccc1>>CC(C)(C)NC(=O)c1ccc(C(F)(F)F)nc1C[C@H](O)[C@H](N)Cc1cc(F)ccc1F,[Pd],CO,O,O=C[O-].[NH4+],,val
US20040018192A1,CC(=O)Cl.NCCc1cccc([N+](=O)[O-])c1>>CC(=O)NCCc1cccc([N+](=O)[O-])c1,,c1ccncc1,,O,,val
US20050182096A1,COC(=O)[C@H](CSCc1ccccn1)NC(c1ccc(F)cc1)C(F)(F)F>>O=C(O)[C@H](CSCc1ccccn1)NC(c1ccc(F)cc1)C(F)(F)F,,CO,,[Na+].[OH-],,val
US04704459,CCOC(=O)c1cn(-c2ccc(F)cc2F)c2nc(O)c(F)cc2c1=O.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CCOC(=O)c1cn(-c2ccc(F)cc2F)c2nc(OS(=O)(=O)c3ccccc3[N+](=O)[O-])c(F)cc2c1=O,,CCOCC,ClCCl,CCN(CC)CC,CCOC(C)=O,val
US04310347,CCOC(=O)C(C)(C)Br.COC(=O)C(C)Oc1ccc(N(C)c2nnc3cc(Cl)ccc3n2)cc1>>CCOC(=O)C(C)(C)Oc1ccc(N(C)c2nnc3cc(Cl)ccc3n2)cc1,,ClCCl,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20020028841A1,CCOC(=O)CCl.NC(=O)c1ccc([N+](=O)[O-])s1>>CCOC(=O)Cc1cc(C(N)=O)sc1[N+](=O)[O-],,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US04227000,CCOC(=O)C(C=O)Cc1cnc(C)c(C)c1.N=C(N)N[N+](=O)[O-]>>Cc1cc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)cnc1C,,CO,,C[O-].[Na+],,val
US20160184318A1,Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)O)n1.c1cnc(N2CCNCC2)nc1>>Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCN(c3ncccn3)CC2)n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05200518,C(=NC1CCCCC1)=NC1CCCCC1.C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)[C@@H](O)C(=O)O>>CCCNC(=O)[C@H](O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C,,C1CCOC1,ClCCl,On1nnc2ccccc21,,val
US20020183512A1,BrCCCCCBr.Cc1cc(C)c(S(=O)(=O)Nc2c3ccccc3nc3ccccc23)c(C)c1>>Cc1cc(C)c(S(=O)(=O)N(CCCCCBr)c2c3ccccc3nc3ccccc23)c(C)c1,,CN(C)C=O,,[H-].[Na+],,val
US20120214803A1,O=[N+]([O-])c1c(C(O)c2ccncc2F)ccc2cccnc12>>O=C(c1ccncc1F)c1ccc2cccnc2c1[N+](=O)[O-],,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20030181468A1,Cc1sc2ncnc(N)c2c1-c1ccc(N)cc1.O=C(Cl)c1ccccc1>>Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)c2ccccc2)cc1,,ClCCl,O,c1ccncc1,,val
US20050228155A1,CC(C)(C)c1ccc2c(c1)-c1cc(C(C)(C)C)ccc1C2.CC(C)=C1C=CC(C(C)(C)C)=C1>>CC(C)(C)C1=CC(C(C)(C)c2cc(C(C)(C)C)cc3c2Cc2ccc(C(C)(C)C)cc2-3)C=C1,,CCOCC,O,CCCCCC,[Li]CCCC,val
US06432993B1,CN(C(=O)OC(C)(C)C)c1cc(Sc2ccc(O)cc2)ccc1[N+](=O)[O-]>>CN(C(=O)OC(C)(C)C)c1cc(Sc2ccc(O)cc2)ccc1N,[Pd],CO,,,,val
US20080009541A1,CCN1C(=O)C(C)CC1COC(c1ccccc1)(c1ccccc1)c1ccccc1.CI>>CCN1C(=O)C(C)(C)CC1COC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20130065876A1,CC(C)(C)OC(=O)N1OC1c1ccc(C#N)cc1.CC(C)(C)[Si](C)(C)OC1CNC1>>CC(C)(C)OC(=O)NN1CC(O[Si](C)(C)C(C)(C)C)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090156600A1,CCc1nc2c(Cl)ccc(OCC(=O)OC)c2c(OC(F)F)c1Cc1ccc(Cl)cc1F>>CCc1nc2c(Cl)ccc(OCC(=O)O)c2c(OC(F)F)c1Cc1ccc(Cl)cc1F,,C1CCOC1,,[Li+].[OH-],,val
US20130338142A1,C1COCCN1.COc1cc([N+](=O)[O-])ccc1F>>COc1cc([N+](=O)[O-])ccc1N1CCOCC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20160122344A1,COCC(C)(C)C1Cc2cc(OCCCCCCNC(=O)OC(C)(C)C)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21>>COCC(C)(C)C1Cc2cc(OCCCCCCN)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21,,C1CCOC1,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20080021081A1,C[C@@H]1CCCN1C[C@@H]1C[C@H]1c1ccc(Br)cc1.N#Cc1ccc(B(O)O)cc1>>C[C@@H]1CCCN1C[C@@H]1C[C@H]1c1ccc(-c2ccc(C#N)cc2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC(C)O,,O=C([O-])[O-].[K+].[K+],,val
US20130252952A1,CC(=O)Cl.Fc1ccc(Br)c(F)c1>>CC(=O)c1cc(Br)c(F)cc1F,,CCOC(C)=O,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20070293470A1,COC(=O)c1ccc2c(c1)CCC1(CCNC1=O)C2>>O=C(O)c1ccc2c(c1)CCC1(CCNC1=O)C2,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20150051225A1,COc1ccccc1C#N.N#Cc1ccc(N)cc1>>COc1ccccc1C(=N)Nc1ccc(C#N)cc1,,Cc1ccccc1,,C[Al](C)C,,val
US20030105087A1,CCOC(=O)CC=Cc1c2n(c3ccc(OC)nc13)Cc1ccccc1-2>>COc1ccc2c(n1)c(CCCC(=O)O)c1n2Cc2ccccc2-1,,CCO,,[Na+].[OH-],,val
US05053426,CC1(C)OCC(C)(C)C(C(=O)NCCC(=O)NCCN)O1.CCCCCCCC/C=C\CCCCCCCC(=O)Cl>>CCCCCCCC/C=C\CCCCCCCC(=O)NCCNC(=O)CCNC(=O)C1OC(C)(C)OCC1(C)C,,C1CCOC1,,CCN(CC)CC,,val
US20120136023A1,C=CCOc1cc(C)ccc1-c1c(C(=O)C(=O)OCC)c(C)nc2sc3c(c12)CCCC3>>C=CCOc1cc(C)ccc1-c1c(C(O)C(=O)OCC)c(C)nc2sc3c(c12)CCCC3,,CCO,,Cl,[BH4-].[Na+],val
US05817851,CC(=O)CC(C)=O.Cl[Sn]Cl.O=C(Cl)C=Cc1ccccc1>>CC(=O)C=C(C)[Sn](Cl)(Cl)Cl,,CCOCC,,,,val
US20050113580A1,CN(C)S(=O)(=O)c1cccc(O)c1.Cl.OCCCN(Cc1cccc(Cl)c1C(F)(F)F)CC(c1ccccc1)c1ccccc1>>CN(C)S(=O)(=O)c1ccccc1OCCCN(Cc1cccc(Cl)c1C(F)(F)F)CC(c1ccccc1)c1ccccc1.Cl,,CCOCC,ClCCl,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140045823A1,CCOC(=O)c1sc(-c2ccc(C#N)cc2F)nc1C>>Cc1nc(-c2ccc(C#N)cc2F)sc1C(=O)O,,C1CCOC1,,[Na+].[OH-],,val
US20090291940A1,CCO.Clc1nc(Cl)c2sccc2n1>>CCOc1nc(Cl)nc2ccsc12,,O,,[Na+].[OH-],,val
US20130072487A1,CCOC(=O)c1c(O)n(-c2cccc(C(F)(F)F)c2)c(=O)n(Cc2ccccc2)c1=O.NCC(=O)O>>O=C(O)CNC(=O)c1c(O)n(-c2cccc(C(F)(F)F)c2)c(=O)n(Cc2ccccc2)c1=O,,CCO,Cl,C1CCC2=NCCCN2CC1,,val
US20140155419A1,Cc1cc(Cl)ccc1C(CC(C)C)NC(=O)Cc1ccc(O)cc1.Cc1ncccc1CCl>>Cc1cc(Cl)ccc1C(CC(C)C)NC(=O)Cc1ccc(OCc2cccnc2C)cc1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080132539A1,CC(C)(C)OC(=O)N[C@@H](CCC(=O)Nc1ccccc1Nc1ccccc1)C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N[C@@H](CCc1nc2ccccc2n1-c1ccccc1)C(=O)OCc1ccccc1,,CC(=O)O,,,,val
US20150011546A1,C=CB1OC(C)(C)C(C)(C)O1.COC(=O)c1c(Br)[nH]c2ccccc12>>C=Cc1[nH]c2ccccc2c1C(=O)OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090270412A1,CCC1c2[nH]c3ccc(Cl)cc3c2CCN1C.COc1ccc(C(C)=CBr)cc1>>CCC1c2c(c3cc(Cl)ccc3n2C=C(C)c2ccc(OC)cc2)CCN1C,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20090093454A1,N#CCCCCn1c(CN2CCC[C@@H]3CCc4cccnc4[C@H]32)nc2ccccc21>>NCCCCCn1c(CN2CCC[C@@H]3CCc4cccnc4[C@H]32)nc2ccccc21,[Ni],CO,N,,,val
US05292760,C=O.Cc1ccsc1C(Cc1ccccc1N)N(C)C=O.O=C1CCC(=O)N1>>Cc1ccsc1C(Cc1ccccc1NCN1C(=O)CCC1=O)N(C)C=O,,CCO,,,,val
US20150344473A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)C1.CS(=O)(=O)n1c(I)cc2c(-c3ccc(OC4CCOCC4)c(C#N)c3)ccnc21>>CC(C)(C)OC(=O)N1CC=C(c2cc3c(-c4ccc(OC5CCOCC5)c(C#N)c4)ccnc3n2S(C)(=O)=O)C1,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080269445A1,C1=Cc2ccccc2C1.FC(F)(F)c1ccccc1CCl>>FC(F)(F)c1ccccc1CC1C=Cc2ccccc21,,CCOCC,,O,[Li]CCCC,val
US04268693,COc1cccc(Oc2ccc(Cl)cc2Cl)c1>>Oc1cccc(Oc2ccc(Cl)cc2Cl)c1,,Clc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20050288273A1,COC(=O)Cl.NC[C@H]1CN(c2ccc3c(c2)CCCc2cnoc2-3)C(=O)O1>>COC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCc2cnoc2-3)C(=O)O1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US06306887B1,COC(=O)CCc1cnc(C2CCCN2C(=O)OC(C)(C)C)s1>>COC(=O)CCc1cnc(C2CCCN2)s1,,C1COCCO1,,Cl,,val
US20110230483A1,COC(=O)c1nc(OC)c(C(F)(F)F)cc1-n1c(C)ccc1C>>COC(=O)c1nc(O)c(C(F)(F)F)cc1-n1c(C)ccc1C,,CC#N,,C[Si](C)(C)Cl,,val
US20100286145A1,O=C1CCC(=O)N1Br.O=Cc1cccc(C(F)(F)F)c1>>O=Cc1cc(Br)cc(C(F)(F)F)c1,,O,O=S(=O)(O)O,,,val
US05493030,CCOC(=O)C(C)C.COCCOCOc1c(CCC(C)C[C@H](C)C(=O)N2C(=O)OC[C@H]2C(C)C)c(OC)c(C)c2c1C(=O)OC2>>CCOC(=O)C(C)(C)C/C(C)=C/Cc1c(OC)c(C)c2c(c1OCOCCOC)C(=O)OC2,,C1CCOC1,CN(C)P(=O)(N(C)C)N(C)C,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20030078288A1,CC(C)(C)[Si](C)(C)Cl.CC(C)c1c[nH]c2ccc(Br)cc12>>CC(C)c1cn([Si](C)(C)C(C)(C)C)c2ccc(Br)cc12,,C1CCOC1,,O,[H-].[Na+],val
US20070287708A1,Cc1c(Nc2c(C#N)cncc2-c2cc3cc(CN4CCN(C(=O)OC(C)(C)C)CC4)ccc3o2)ccc2[nH]ccc12>>Cc1c(Nc2c(C#N)cncc2-c2cc3cc(CN4CCNCC4)ccc3o2)ccc2[nH]ccc12,,ClCCl,O=C(O)C(F)(F)F,,,val
US20160052922A1,Cc1nn(C(C)C)c2nc(-c3cccc(O)c3)cc(N3CCOCC3)c12.ClCC1CO1>>Cc1nn(C(C)C)c2nc(-c3cccc(OCC4CO4)c3)cc(N3CCOCC3)c12,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20160137704A1,C=CCCC1(O)SC[C@@H]2OC(C)(C)O[C@@H]21>>C=CCC[C@@H]1SC[C@H](O)[C@@H]1O,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US05660974,CC(C)NO.COC(=O)c1ccc(CCl)cc1>>COC(=O)c1ccc(CN(O)C(C)C)cc1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20130330457A1,COC(=O)CCCCCCCC(C)=O>>COC(=O)CCCCCCCC(C)O,,CO,ClCCl,[BH4-].[Na+],,val
US20060183736A1,COc1cc(-c2ccc3cc(OC(C)=O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)ccc1S(C)(=O)=O>>COc1cc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)ccc1S(C)(=O)=O,,CO,,O=C([O-])O.[Na+],,val
US20090048263A1,CC(C)(C)OC(=O)N1CCN(c2ccc(Br)cn2)CC1.OB(O)c1ccccc1>>CC(C)(C)OC(=O)N1CCN(c2ccc(-c3ccccc3)cn2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20150210687A1,COC(=O)c1cc(F)c(-c2n[nH]c3cccc(F)c23)cc1OC.Clc1cccc(C2CC2)c1CBr>>COC(=O)c1cc(F)c(-c2nn(Cc3c(Cl)cccc3C3CC3)c3cccc(F)c23)cc1OC,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05646164,CC(=O)CCl.O=c1ccc2ccc(O)cc2o1>>CC(=O)COc1ccc2ccc(=O)oc2c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04285944,CC1OC2(C)CCC1C(=NO)C2=O.NN>>CC1OC2(C)CCC1C(=NO)C2=NN,,CCO,,,,val
US06177443B1,CN(C)c1ccc(C=O)cc1.NCCc1cccs1>>CN(C)c1ccc(C=NCCc2cccs2)cc1,,CCO,,,,val
US20090143367A1,Cc1nc(-c2ccccc2Cl)n2c1c(C)nc1cc(O)ccc12.Fc1cccc(F)c1CBr>>Cc1nc(-c2ccccc2Cl)n2c1c(C)nc1cc(OCc3c(F)cccc3F)ccc12,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20140171388A1,CCCCCCCCCCCCCCCBr.Cc1cccc(C(=O)O)c1>>CCCCCCCCCCCCCCCCc1cccc(C(=O)O)c1,,C1CCOC1,,Cl,CC(C)[N-]C(C)C.[Li+],val
US20160155949A1,CC1(C)OB(c2cccc(B3OC(C)(C)C(C)(C)O3)c2)OC1(C)C.Clc1ccc2ccc3cccnc3c2n1>>CC1(C)OB(c2cccc(-c3ccc4ccc5cccnc5c4n3)c2)OC1(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20060166940A1,CC1=NC(CO)(CCc2ccc(OCc3ccccc3)cc2)CO1>>CC1=NC(CO)(CCc2ccc(O)cc2)CO1,[Pd],CO,,,,val
US20110195934A1,COc1cc(NC(=O)c2nn(-c3ccc(Cl)cc3)cc2CO)ccc1OCOCC[Si](C)(C)C.CS(=O)(=O)Cl>>COc1cc(NC(=O)c2nn(-c3ccc(Cl)cc3)cc2CCl)ccc1O,,ClCCl,,CCN(CC)CC,,val
US20080182854A1,CC(C)(C)OC(=O)N1CCNCC1.ClCc1cccc(CCl)n1>>CC(C)(C)OC(=O)N1CCN(Cc2cccc(CCl)n2)CC1,,CCO,,,,val
US20140171390A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(O)CC1CCC(=O)CC1>>CC(C)(C)OC(=O)N1CCN(C2CCC(CC(=O)O)CC2)CC1,[Pd],CO,,,,val
US04315029,CC1(C)[C@@H](CC(Cl)(Cl)Cl)[C@@H]1C(=O)Cl.N#CC(O)c1cccc(Oc2ccccc2)c1>>CC1(C)[C@@H](CC(Cl)(Cl)Cl)[C@@H]1C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1,,c1ccccc1,,O,c1ccncc1,val
US20120295902A1,CC(C)(C)OC(=O)N1CCN(c2ccc(-c3cncc(-c4cc(-c5cc(Cl)ccc5F)nc5ncccc45)c3)cn2)CC1.Cl>>Cl.Fc1ccc(Cl)cc1-c1cc(-c2cncc(-c3ccc(N4CCNCC4)nc3)c2)c2cccnc2n1,,C1COCCO1,,,,val
US20030065212A1,CCOC(=O)CC(C)=O.ClCCCl>>CCOC(=O)C1(C(C)=O)CC1,,CC(=O)N(C)C,,[I-].[K+],,val
US20110172237A1,O=C(CCl)Nc1ccccn1.O=C(O[C@H]1CN2CCC1CC2)C1(c2ccccc2)CCCCCC1>>O=C(C[N+]12CCC(CC1)[C@@H](OC(=O)C1(c3ccccc3)CCCCCC1)C2)Nc1ccccn1.[Cl-],,CC#N,,,,val
US20130053366A1,Cc1ccc2c(c1)c1c(n2CC(OS(C)(=O)=O)c2ccc(F)cc2)CCN2CCCC12.[N-]=[N+]=[N-]>>Cc1ccc2c(c1)c1c(n2CC(N=[N+]=[N-])c2ccc(F)cc2)CCN2CCCC12,,CN(C)C=O,,O,,val
US20100227862A1,ClC/C=C/c1ccc(Cl)cc1.O=C(c1ccnc(Cl)c1)N1CC(c2ccc(F)cc2)C2(CCNCC2)C1>>O=C(c1ccnc(Cl)c1)N1CC(c2ccc(F)cc2)C2(CCN(C/C=C/c3ccc(Cl)cc3)CC2)C1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20120302570A1,CC(=O)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1.CCON>>CCO/N=C(\C)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1,,CO,,,,val
US20060025597A1,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1cccc(Cl)c1>>O=C1CCC(N2C(=O)c3cccc(NC(=O)c4cccc(Cl)c4)c3C2=O)C(=O)N1,,C1CCOC1,CCOCC,CO,,val
US20090163586A1,Cc1ccc(N)c(S(N)(=O)=O)c1.O=S(=O)(Cl)CCc1ccc(Cl)cc1>>Cc1ccc(NS(=O)(=O)CCc2ccc(Cl)cc2)c(S(N)(=O)=O)c1,,c1ccncc1,,,,val
US20070072857A1,COc1ccc(N)cc1-c1c(Br)cnn1C.O=C=Nc1ccc(Cl)cc1Cl>>COc1ccc(NC(=O)Nc2ccc(Cl)cc2Cl)cc1-c1c(Br)cnn1C,,ClCCl,,,,val
US04497822,FC(F)(F)c1ccc(Oc2ccc(NSC(Cl)(Cl)Cl)cc2)c(Cl)c1.O=C=NC(=O)c1ccccc1Cl>>O=C(NC(=O)N(SC(Cl)(Cl)Cl)c1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1)c1ccccc1Cl,,Cc1ccccc1,,,,val
US20030087901A1,NCCc1cccc(OCc2ccccc2)c1.O=C(O)Cc1ccc(O)cc1>>O=C(Cc1ccc(O)cc1)NCCc1cccc(OCc2ccccc2)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CCN=C=NCCCN(C)C,val
US20020098152A1,CCCCCCCCCCCCCCCC(=O)OCCN(CCOC(=O)CCCCCCCCCCCCCCC)C(=O)CN1CCN(CC(=O)OCc2ccccc2)CCN(CC(=O)OCc2ccccc2)CCN(CC(=O)OCc2ccccc2)CC1>>CCCCCCCCCCCCCCCC(=O)OCCN(CCOC(=O)CCCCCCCCCCCCCCC)C(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1,[Pd],CCO,,,,val
US20070142230A1,CCOC(=O)CN=C(c1ccccc1)c1ccccc1.Cc1ccccc1C(=O)Cl.Cl>>CCOC(=O)C(N)C(=O)c1ccccc1C.Cl,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20090156607A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc2cc(C=O)cnc21.CCCC(CC(=O)OCC)C[N+](=O)[O-]>>CCCC1CC(=O)N(Cc2cnc3c(ccn3[Si](C(C)C)(C(C)C)C(C)C)c2)C1,[Pd],CCOCC,CO,O=C[O-].[NH4+],,val
US20150191481A1,CC(=O)Nc1ccc(C(C)=O)c(O)c1[N+](=O)[O-].CN(C)c1ccc(C(=O)Cl)cc1>>CC(=O)Nc1ccc(C(C)=O)c(OC(=O)c2ccccc2)c1[N+](=O)[O-],,ClCCl,,CCN(CC)CC,,val
US20130085144A1,CSc1nc(O)ccc1C#N.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CSc1nc(OS(=O)(=O)C(F)(F)F)ccc1C#N,,C1CCOC1,,O,CC(C)(C)[O-].[K+],val
US20040063954A1,COC1(OC)CCN(c2ccc(N3C[C@@H](CN=[N+]=[N-])OC3=O)cc2)CC1(F)F>>COC1(OC)CCN(c2ccc(N3C[C@H](CN)OC3=O)cc2)CC1(F)F,[Pd],CCOC(C)=O,,,,val
US20160083403A1,CC1(C)OB(c2ccc(C(=O)Cl)cc2[N+](=O)[O-])OC1(C)C.Cc1cc(C)cc(C(=O)N(N)C(C)(C)C)c1>>Cc1cc(C)cc(C(=O)N(NC(=O)c2ccc(B3OC(C)(C)C(C)(C)O3)c([N+](=O)[O-])c2)C(C)(C)C)c1,,O,,ClCCl,O=C([O-])[O-].[K+].[K+],val
US20030055085A1,BrBr.Nc1ccc(C(=O)O)cc1OC(F)(F)F>>Nc1c(Br)cc(C(=O)O)cc1OC(F)(F)F,,CC(=O)O,,O,,val
US04072688,O=C(Cl)CCBr.c1ccc(C2CNCO2)cc1>>O=C(CCBr)N1COC(c2ccccc2)C1,,CCN(CC)CC,,c1ccccc1,,val
US20080182874A1,N#CCCCCc1ccc2c(C(=O)NCC34CC5CC(CC(C5)C3)C4)c(Cl)ccc2n1.NO>>NC(CCCCc1ccc2c(C(=O)NCC34CC5CC(CC(C5)C3)C4)c(Cl)ccc2n1)=NO,,CCO,,,,val
US20130252962A1,O=C1Nc2cc3c(cc2C12COc1cc4c(cc12)CC(C(c1ccccc1)c1ccccc1)O4)OCCO3>>O=C1Nc2cc3c(cc2C12COc1cc4c(cc12)CCO4)OCCO3,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20120027874A1,CN(Cc1ccc(-c2cc(-c3nc(-c4ccc(=O)[nH]c4)cnc3N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)on2)cc1)C(=O)OC(C)(C)C.O=C1CCC(=O)N1Br>>CN(Cc1ccc(-c2cc(-c3nc(-c4c[nH]c(=O)c(Br)c4)cnc3N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)on2)cc1)C(=O)OC(C)(C)C,,C1CCOC1,,,,val
US04153692,CC(=O)Cl.CC(C)(C)C(O)C(Oc1ccccc1)n1ccnc1>>CC(=O)OC(C(Oc1ccccc1)n1ccnc1)C(C)(C)C,,CCOC(C)=O,,,,val
US20160214972A1,CCOC(=O)COCCCCCN(C)C(=O)OC(C)(C)C>>CCOC(=O)COCCCCCNC,,ClCCl,,O=C(O)C(F)(F)F,,val
US04219660,CC(=CC=O)C[N+](=O)[O-].OCCO>>CC(=CC1OCCO1)C[N+](=O)[O-],,c1ccccc1,,O,,val
US20130252937A1,CNC.Cc1cc(C(=O)O)cc(C)c1[N+](=O)[O-]>>Cc1cc(C(=O)N(C)C)cc(C)c1[N+](=O)[O-],,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20140243336A1,Cc1cc(C)nc(Nc2cc(NC(=O)CNC(=O)OCC3c4ccccc4-c4ccccc43)cnc2C#N)c1>>Cc1cc(C)nc(Nc2cc(NC(=O)CN)cnc2C#N)c1,,CN(C)C=O,,C1CCNCC1,,val
US05981546,II.O=C1CC[C@@H](CO)N1Cc1ccccc1>>O=C1CC[C@@H](CI)N1Cc1ccccc1,,CC#N,CCOCC,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070259851A1,O=[N+]([O-])c1ccccc1CCNC1CCN(Cc2ccccc2)CC1>>Nc1ccccc1CCNC1CCN(Cc2ccccc2)CC1,O=[Pt]=O,CO,,[H][H],,val
US20120157430A1,Brc1ncnc2[nH]cnc12.Cc1c(Cl)cc(C(C)N)c(-c2ccccc2)c1-c1cc(F)nc(F)c1>>Cc1c(Cl)cc(C(C)Nc2ncnc3[nH]cnc23)c(-c2ccccc2)c1-c1cc(F)nc(F)c1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20090298823A1,N.O=C(O)CC1CCN(c2nc(Nc3ccc4c(c3)CCC(=O)N4)nc3[nH]ccc23)CC1>>NC(=O)CC1CCN(c2nc(Nc3ccc4c(c3)CCC(=O)N4)nc3[nH]ccc23)CC1,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20140023611A1,CNCCC(=O)NCCOC.O=C(O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1>>COCCNC(=O)CCN(C)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US05032583,O=C(OCc1ccccc1)N1OC2CCC1C2>>O=C(N[C@H]1CC[C@@H](O)C1)OCc1ccccc1,[Zn],CC(=O)O,O,,,val
US20110178117A1,CCCCCCC(=O)CBr.Clc1nc2ccccc2[nH]1>>CCCCCCC(=O)Cn1c(Cl)nc2ccccc21,,CS(C)=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070238726A1,COc1ccc(Cn2nc(N3CC4CN(C(=O)OC(C)(C)C)CC4C3)c3c(Oc4ccc(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)ccnc32)cc1>>COc1ccc(Cn2nc(N3CC4CNCC4C3)c3c(Oc4ccc(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)ccnc32)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05708030,CCOC(=O)C(CC(=O)c1cc(Cl)ccc1N)(NC(C)=O)C(=O)OCC>>Nc1ccc(Cl)cc1C(=O)CC(N)C(=O)O,,Cl,,,,val
US20080015187A1,CN1CCn2nc(C(=O)O)c(OCc3ccccc3)c2C1=O.c1ccc2c(c1)CCNC2>>CN1CCn2nc(C(=O)N3CCc4ccccc4C3)c(OCc3ccccc3)c2C1=O,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20140274696A1,C=Cc1c(C(=O)OC)nc(-c2ccc(Cl)c(F)c2)c(F)c1NC(=O)OC(C)(C)C>>C=Cc1c(C(=O)OC)nc(-c2ccc(Cl)c(F)c2)c(F)c1N,,CC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20090156600A1,CC(=O)OC(F)(F)Cl.CCc1[nH]c2c(F)ccc(OCC(=O)OC)c2c(=O)c1Cc1ccc(F)cc1>>CCc1nc2c(F)ccc(OCC(=O)OC)c2c(OC(F)F)c1Cc1ccc(F)cc1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20100331312A1,COc1ccc(COc2ccc(CCO)cc2Cl)cc1.CS(=O)(=O)Cl>>COc1ccc(COc2ccc(CCOS(C)(=O)=O)cc2Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20130143907A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)c1cnn([C@H]2CCOC2)c1-c1cc(F)c(Br)cc1F>>CCOC(=O)c1cnn([C@H]2CCOC2)c1-c1cc(F)c(B2OC(C)(C)C(C)(C)O2)cc1F,,CN(C)C=O,,CC(=O)[O-].[K+],,val
US07361766B2,CC(C)(C)OC(=O)Nc1ccncc1C=O.CCOP(=O)(OCC)C(NC(=O)OCc1ccccc1)C(=O)OC>>COC(=O)/C(=C/c1cnccc1NC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20070293516A1,CCI.Nc1ncnc2[nH]nc(-c3ccc4ccccc4c3)c12>>CCn1nc(-c2ccc3ccccc3c2)c2c(N)ncnc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100311729A1,CS(=O)(=O)OCCCN1CCCC1=O.Oc1ccc(-c2ccc3nccn3n2)cc1>>O=C1CCCN1CCCOc1ccc(-c2ccc3nccn3n2)cc1,,CC(=O)N(C)C,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20050080124A1,CCOc1ccc(N)cc1-c1c(Br)cnn1C.O=C=Nc1ccc(F)cc1>>CCOc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1c(Br)cnn1C,,ClCCl,,,,val
US20050049245A1,CNCC(O)c1cccn1C.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)sc21>>CN(Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2s1)CC(O)c1cccn1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US06384041B1,CCc1cc2c(OCC(=O)OC)ncnc2n1Cc1cccc(F)c1.O=C(Cl)C(=O)Cl.c1ccncc1>>CCc1c(C(=O)C(N)=O)c2c(OCC(=O)OC)ncnc2n1Cc1cccc(F)c1,,ClC(Cl)Cl,,,,val
US20150141453A1,CC1(C)OB(c2ccc(COC(=O)Nc3c(CO[Si](C)(C)C(C)(C)C)cccc3CO[Si](C)(C)C(C)(C)C)cc2)OC1(C)C>>CC1(C)OB(c2ccc(COC(=O)Nc3c(CO)cccc3CO)cc2)OC1(C)C,,ClCCl,O=C(O)C(F)(F)F,,,val
US20090318690A1,CCOCc1ccc2c(CCC3CCN(C(=O)OC(C)(C)C)CC3)noc2c1CO[Si](C)(C)C(C)(C)C>>CCOCc1ccc2c(CCC3CCN(C(=O)OC(C)(C)C)CC3)noc2c1CO,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20100292238A1,COc1ccc(C2=C(c3ccc(OCc4cn5ncccc5n4)cc3)C(=O)C(C)(C)O2)cc1.CS(=O)(=O)O>>COc1ccc(C2=C(c3ccc(OCc4cn5ncccc5n4)cc3)C(=O)C(C)(C)O2)cc1.CS(=O)(=O)O,,CCOCC,ClCCl,,,val
US20100280005A1,COC(=O)CC(O)CN(CCBr)S(=O)(=O)c1ccccc1[N+](=O)[O-]>>COC(=O)CC1CN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CCO1,,CN(C)C=O,,[H-].[Na+],,val
US04640918,C1CSCCN1.Oc1ccc(O)cc1>>Oc1ccc(N2CCSCC2)cc1,Cl[Cu],,,,,val
US20080306275A1,CCOC(=O)C(C)(C)Br.OCCc1ccc(Br)cc1>>CCOC(=O)C(C)(C)OCCc1ccc(Br)cc1,,C1CCOC1,,CCOC(C)=O,[H-].[Na+],val
US20080207611A1,CC(=O)SC1CCN(C(=O)OC(C)(C)C)CC1.COCCCOS(=O)(=O)c1ccc(C)cc1>>COCCCSC1CCN(C(=O)OC(C)(C)C)CC1,,CO,O,C[O-].[Na+],,val
US20100197683A1,CCCC(=O)CC(=O)OCC.N#Cc1ccccc1-c1ccc(CBr)cc1[N+](=O)[O-]>>CCCC(=O)C(Cc1ccc(-c2ccccc2C#N)c([N+](=O)[O-])c1)C(=O)OCC,,C1CCOC1,,Cl,[H-].[Na+],val
US20120214997A1,C=C[Mg]Br.Fc1cc(F)c(C[C@H]2CO2)cc1F>>C=CC[C@@H](O)Cc1cc(F)c(F)cc1F,,C1CCOC1,,Cl,,val
US20110086858A1,CCOC(=O)C1(Nc2nc(Nc3ccc(C(=O)OC(C)(C)C)cc3)nc(OCC(F)(F)F)n2)CC1>>CCOC(=O)C1(Nc2nc(Nc3ccc(C(=O)O)cc3)nc(OCC(F)(F)F)n2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090042874A1,CC(C)(C)OC(=O)N1CCCC(=O)C1.CCOP(=O)(Cc1ccc(OC)c([N+](=O)[O-])c1)OCC>>COc1ccc(C=C2CCCN(C(=O)OC(C)(C)C)C2)cc1[N+](=O)[O-],,C1CCOC1,O,[H-].[Na+],,val
US20120130084A1,O=C(O)CCc1cccc(F)c1>>O=C1CCc2cc(F)ccc21,,O,,,,val
US20150057265A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.COC(=O)[C@@H]([C@@H](O)[C@H]1COC(C)(C)N1C(=O)OC(C)(C)C)C(F)(F)F>>COC(=O)[C@@H]([C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1COC(C)(C)N1C(=O)OC(C)(C)C)C(F)(F)F,,ClCCl,,Cc1cccc(C)n1,,val
US04831151,CCc1nccn1N.CN(C)c1ccc(C=O)cc1.Cl>>CCc1nccn1N=Cc1ccc(N(C)C)cc1.Cl,,CC(=O)O,,,,val
US03978127,CC(C)(N)c1ccc(C(F)(F)C(F)(F)c2ccccc2)cc1.O=S(=O)(O)CCO>>CC(C)(N)c1ccc(C(F)(F)C(F)(F)c2ccccc2)cc1.O=S(=O)([O-])CCO,,CC(C)O,,,,val
US20070219216A1,Cl.O=C1C2CC(F)C(F)CC2C(=O)N1CCCN1CCN(c2cc(F)ccc2OC2CCCC2)CC1>>Cl.O=C1C2CC(F)C(F)CC2C(=O)N1CCCN1CCN(c2cc(F)ccc2OC2CCCC2)CC1,,CCOCC,,CC(C)O,,val
US20100144714A1,COC(=O)CC(C)(C)n1c(=S)[nH]c2ccccc2c1=O.O=P(Cl)(Cl)Cl>>COC(=O)CC(C)(C)n1c(Cl)nc2ccccc2c1=O,,O=P(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20130040978A1,CCOc1cc(CO)c(Br)cc1C>>CCOc1cc(C=O)c(Br)cc1C,,CCOCC,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US06028213,CCO.CCOC(OCC)OCC.O=C1OC(=O)[C@H]2CCC[C@@H]1C2>>CCOC(=O)[C@@H]1CCC[C@H](C(=O)OCC)C1,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05744627,COC(=O)c1ccc(CN)cc1O.O=C(OCc1ccccc1)ON1C(=O)CCC1=O>>COC(=O)c1ccc(CNC(=O)OCc2ccccc2)cc1O,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,Cl,val
US05190575,CSC(=CN(C)C)C(=O)c1cccc(C(F)(F)F)c1.N=C(N)c1ccc(Cl)cc1>>CSc1cnc(-c2ccc(Cl)cc2)nc1-c1cccc(C(F)(F)F)c1,,CO,,CC(=O)O,C[O-].[Na+],val
US20070293678A1,O=C(O)C1CCC(c2cc3cccnc3c(-c3cccc(F)c3)n2)CC1>>O=C(O)[C@@H]1CC[C@@H](c2cc3cccnc3c(-c3cccc(F)c3)n2)CC1,,CC#N,,O,[Na+].[OH-],val
US20110257100A1,BrCCc1ccc(Br)nc1.O=C1CCCN1>>O=C1CCCN1CCc1ccc(Br)nc1,,CCOC(C)=O,CO,[H-].[Na+],,val
US20110039889A1,CC(C)Cn1ccc(C(=O)O)cc1=O.N=C(NO)c1cccc2cnccc12>>CC(C)Cn1ccc(-c2nc(-c3cccc4cnccc34)no2)cc1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090118259A1,CCOC(=O)C1CC1c1nc2cc(C(=O)N3CC4(C)CC3CC(C)(C)C4)ccc2[nH]1>>CC1(C)CC2CC(C)(CN2C(=O)c2ccc3[nH]c(C4CC4C(=O)O)nc3c2)C1,,CCO,,[Na+].[OH-],,val
US04889553,Clc1ncccn1.c1ccc(CSc2n[nH]c(SCc3ccccc3)n2)cc1>>c1ccc(CSc2nc(SCc3ccccc3)n(-c3ncccn3)n2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100063054A1,Cc1nc(Cl)ccc1F.NN>>Cc1nc(NN)ccc1F,,CC(C)O,,O,,val
US05840732,O=C1CSC(=O)N1CBr.Sc1cccc2nccn12>>O=C1CSC(=O)N1CSc1cccc2nccn12,,CCO,,CCN(CC)CC,,val
US05096919,CNC(=O)N(OCc1ccccc1)C(C)c1ccc(-n2c(C)ccc2C)cc1>>CNC(=O)N(O)C(C)c1ccc(-n2c(C)ccc2C)cc1,,CCOC(C)=O,,,,val
US20060264431A1,COC(=O)[C@](C)(CCN(C)C)NC(=O)c1cc2c(cnn2CC(C)C)cc1Oc1ccc(F)cc1F>>CC(C)Cn1ncc2cc(Oc3ccc(F)cc3F)c(C(=O)N[C@](C)(CO)CCN(C)C)cc21,,C1CCOC1,CO,[BH4-].[Na+],,val
US04188378,[N-]=[N+]=Nc1nc(N=[N+]=[N-])c2ncn([C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc4ccccc4)[C@@H]3OCc3ccccc3)c2n1>>Nc1nc(N)c2ncn([C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc4ccccc4)[C@@H]3OCc3ccccc3)c2n1,[Pd],CCO,,ClC(Cl)Cl,,val
US20120101095A1,CS(=O)c1nc(-c2cccc(Cl)c2)c2c(N)c(C(N)=O)sc2n1.NC(=O)CO>>NC(=O)COc1nc(-c2cccc(Cl)c2)c2c(N)c(C(N)=O)sc2n1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20130085138A1,Cn1c(CCc2ccc3c(cnn3C3CCCCO3)c2)nnc1Nc1ccc(OC(F)F)cc1>>Cn1c(CCc2ccc3[nH]ncc3c2)nnc1Nc1ccc(OC(F)F)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20010051633A1,O=C(CCCCl)c1ccccc1.OC1CCNCC1>>O=C(CCCN1CCC(O)CC1)c1ccccc1,,Cc1ccccc1,,[I-].[K+],O=C([O-])O.[Na+],val
US20100076046A1,COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(CN(C)CCN(C)CCS(=O)(=O)NCc1ccccc1)Oc1ccccc1-3>>CN(CCN(C)CC1Cn2c(c(C3CCCCC3)c3ccc(C(=O)O)cc32)-c2ccccc2O1)CCS(=O)(=O)NCc1ccccc1,,C1CCOC1,CCOCC,Cl,[K+].[OH-],val
US20110263612A1,COc1cc(Br)c(C)cc1N>>Cc1cc(N)c(O)cc1Br,,ClCCl,,BrB(Br)Br,,val
US20080280910A1,NN.O=C1OC(=Cc2cncc(Br)c2)c2ccccc21>>O=c1[nH]nc(Cc2cncc(Br)c2)c2ccccc12,,O,,,,val
US05102880,Cc1ccc(-c2ccc(Cl)cc2-c2nnn[nH]2)cc1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cc1ccc(-c2ccc(Cl)cc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,CCOCC,ClCCl,CCN(CC)CC,,val
US05283248,CCNc1cc(N2CCN(C)CC2)c(F)cc1NC(N)=O.CCOC(=O)CC(=O)OCC>>CCn1c2cc(N3CCN(C)CC3)c(F)cc2n2c(=O)[nH]c(=O)cc12,,CO,,Cl,C[O-].[Na+],val
US20090030041A1,COC(=O)C1(N(C(=O)c2ccco2)c2cccc(NC(=O)OC(C)(C)C)c2)CCN(CC(C(=O)OCc2ccccc2)c2ccccc2)CC1>>COC(=O)C1(N(C(=O)c2ccco2)c2cccc(N)c2)CCN(CC(C(=O)OCc2ccccc2)c2ccccc2)CC1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20160214997A1,COc1ccc(CNc2nc3c4c(ccc3c3nc(C5CCCNC5)nn23)OC(F)(F)O4)c(OC)c1.FC(F)(F)CCI>>COc1ccc(CNc2nc3c4c(ccc3c3nc(C5CCCN(CCC(F)(F)F)C5)nn23)OC(F)(F)O4)c(OC)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20010051733A1,CC(=O)c1cc(C)c2c(c1Cl)C(C)(C)CCS2.OO>>CC(=O)c1cc(C)c2c(c1Cl)C(C)(C)CCS2(=O)=O,,CC(=O)O,,O=S([O-])O.[Na+],,val
US04613603,CN(C)C=C(C=O)c1ccccc1Cl.NC(N)=O>>O=c1ncc(-c2ccccc2Cl)c[nH]1,,CCO,,Cl,,val
US20060154960A1,CCN=C=O.CCc1n[nH]c2cc(-c3ccnn3-c3ccc(S(C)(=O)=O)cc3)ccc12>>CCNC(=O)n1nc(CC)c2ccc(-c3ccnn3-c3ccc(S(C)(=O)=O)cc3)cc21,,c1ccncc1,,CCOC(C)=O,O,val
US20080261965A1,C1=NN=CC1.CN(C)C=O.Nc1ccc(Oc2ccnc(Cl)c2)cc1>>Cn1cc(-c2cc(Oc3ccc(N)cc3)ccn2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20020016347A1,Cc1ccccc1C(=O)c1ccc(N)cc1Cl.O=[N+]([O-])c1ccc(Cl)nc1>>Cc1ccccc1C(=O)c1ccc(Nc2ccc([N+](=O)[O-])cn2)cc1Cl,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20140142083A1,COC(=O)c1cc(Cl)cc(N)c1C.O=C1CCCCC1>>COC(=O)c1cc(Cl)cc(NC2CCCCC2)c1C,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20090203737A1,Cc1oncc1C(=O)O.c1c[nH]c(-c2noc([C@H]3CCCNC3)n2)c1>>Cc1oncc1C(=O)N1CCC[C@H](c2nc(-c3ccc[nH]3)no2)C1,,CCCCCC,CCOC(C)=O,Cl,,val
US20140275064A1,CN(C)/C=N/c1ccc2nc(C#N)sc2c1C#N.Nc1ccc(F)cc1F>>N#Cc1nc2ccc3ncnc(Nc4ccc(F)cc4F)c3c2s1,,CCOC(C)=O,ClCCl,[Br-].[K+],,val
US20100311714A1,CC(C)Oc1cc(Br)cnc1CO.CI>>COCc1ncc(Br)cc1OC(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20020173646A1,CC(=O)N1CCNCC1.COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCBr.ClCCl>>COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCN1CCN(C(C)=O)CC1.Cl,,CCOC(C)=O,ClCCl,,,val
US20120088767A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.Cc1nc2c(O)cc(N3CCOCC3)cc2n1Cc1cccc2ccccc12>>Cc1nc2c(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc(N3CCOCC3)cc2n1Cc1cccc2ccccc12,,ClCCl,,c1c[nH]cn1,,val
US20040044052A1,CN1C(=O)CSc2cc([N+](=O)[O-])ccc21>>CN1C(=O)CSc2cc(N)ccc21,[Fe],CCO,O,[Cl-].[NH4+],,val
US20150158847A1,COc1cc(CNC(=O)OC(C)(C)C)ccc1O.COc1ccc(CCl)cn1>>COc1ccc(COc2ccc(CNC(=O)OC(C)(C)C)cc2OC)cn1,,CC#N,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20090124596A1,CC(C)N.CS(=O)(=O)OCCCc1ccc(-c2cccc(-n3c(=O)n([C@@H]4CC[C@H](NC(=O)c5cn6cc(F)ccc6n5)CC4)c(=O)c4cc(F)cnc43)c2)cc1>>CC(C)NCCCc1ccc(-c2cccc(-n3c(=O)n([C@@H]4CC[C@H](NC(=O)c5cn6cc(F)ccc6n5)CC4)c(=O)c4cc(F)cnc43)c2)cc1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US06511974B1,CCC(=O)OC(=O)CC.O=C(c1ccc(-c2cc[nH]n2)cc1)N1Cc2cccn2Cc2ccccc21>>CCC(=O)n1ccc(-c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)n1,,c1ccncc1,,,,val
US20140288123A1,CCc1cccc(O)c1Br.COC(=O)c1ccc(F)c(C)c1>>CCc1cccc(Oc2ccc(C(=O)OC)cc2C)c1Br,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US04654360,CI.O=S(c1ccccc1)c1c[nH]c2ccccc12>>Cn1cc(S(=O)c2ccccc2)c2ccccc21,,CN(C)C=O,O,[H-].[Na+],,val
US20120165306A1,NCC1CCOCC1.Nc1cc(-c2cncc(Cl)n2)c(C(F)(F)F)cn1>>Nc1cc(-c2cncc(NCC3CCOCC3)n2)c(C(F)(F)F)cn1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20140175406A1,Clc1ccc2scc(Br)c2c1.c1ccc2c(c1)[nH]c1ccccc12>>Clc1ccc2scc(-n3c4ccccc4c4ccccc43)c2c1,[Cu]I,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US04752616,O=C(O)Cc1ccc(CCCS(=O)(=O)c2ccc(Cl)cc2)cc1>>O=C(O)Cc1ccc(CCCS(=O)c2ccc(Cl)cc2)cc1,,CC(C)=O,,O=S(=O)(O)O,O=[Cr](=O)=O,val
US04283420,C=CCCl.O=C(O)C1CCCCC1>>C=CCC1(C(=O)O)CCCCC1,,C1CCOC1,,,,val
US05977027,CCOC(=O)C(C)(C)N.O=C(Cl)C(Br)c1ccccc1>>CCOC(=O)C(C)(C)NC(=O)C(Br)c1ccccc1,,CC#N,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20140323463A1,CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1Oc1cncc(N=C(c2ccccc2)c2ccccc2)c1>>CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1Oc1cncc(N)c1,,C1CCOC1,,Cl,,val
US20080182859A1,COc1ccc(-c2cccnc2)cc1CN(C(=O)c1sc2cccc(F)c2c1Cl)C1CCC(NC(=O)OC(C)(C)C)CC1>>COc1ccc(-c2cccnc2)cc1CN(C(=O)c1sc2cccc(F)c2c1Cl)C1CCC(N)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150246902A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc4nccn4c3)cc12.O=C1CCC(=O)N1Br>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc4ncc(Br)n4c3)cc12,,CN(C)C=O,,O,,val
US20030232875A1,O=C1NC(=O)c2ccccc21.OCc1nocc1-c1ccccc1>>O=C1c2ccccc2C(=O)N1Cc1nocc1-c1ccccc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110136780A1,CC(C)[C@H](C(=O)O)N1Cc2c(F)cnc3[nH]cc(c23)C1=O.NC1CCC(F)(F)C1>>CC(C)[C@H](C(=O)NC1CCC(F)(F)C1)N1Cc2c(F)cnc3[nH]cc(c23)C1=O,CN(C)c1ccncc1,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US05616599,CCCCc1nc(C(C)(C)O)c(C#N)n1C(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCc1nc(C(C)(C)O)c(C#N)[nH]1,,CC(=O)O,,,,val
US20060135552A1,CC(=O)CC(=O)C(F)(F)F.Nc1sc2c(c1C(=O)c1cccs1)CCCC2>>Cc1nc2sc3c(c2c(-c2cccs2)c1C(=O)C(F)(F)F)CCCC3,O=S(=O)(O)O,CC(=O)O,,,,val
US20090036677A1,CCC=O.CCCC(CCC)CCCC(O)COCCNCCO>>CCCC(CCC)CCCC(O)COCCN1CCOC1CC,,Cc1ccccc1,,,,val
US20120196864A1,CNC1=NC(=O)SC1.O=Cc1ccc(OCc2ccc(C(F)(F)F)cc2C(F)(F)F)c(F)c1>>CNC1=NC(=O)S/C1=C\c1ccc(OCc2ccc(C(F)(F)F)cc2C(F)(F)F)c(F)c1,,CCO,,O,CC(C)(C)[O-].[K+],val
US06136823,CN.COc1cc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)c(Cl)c32)ccc1F>>CNc1c(F)cc2c(=O)c(C(=O)O)cn(-c3ccc(F)c(OC)c3)c2c1Cl,,c1ccncc1,,,,val
US04137318,COc1ccc(CCN(C)CCCN2C(=O)c3cc(OC)c(OC)cc3C(C)(C)C2=O)cc1OC>>COc1ccc(CCN(C)CCCN2C(=O)c3cc(OC)c(OC)cc3C(C)(C)C2O)cc1OC,,C1COCCO1,O,Cl,[BH4-].[Na+],val
US20080255122A1,CCNS(=O)(=O)Cc1ccccc1.CCOC(=O)C(=O)[O-]>>CCN1C(=O)C(O)=C(c2ccccc2)S1(=O)=O,,C1CCOC1,,Cl,CC(C)(C)[O-].[K+],val
US20050182048A1,CCSCCCN(C)c1c(S(=O)(=O)C(F)(F)F)c(C#N)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl.O=C(OO)c1cccc(Cl)c1>>CCS(=O)CCCN(C)c1c(S(=O)(=O)C(F)(F)F)c(C#N)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl,,ClCCCl,,CCOC(C)=O,O=C([O-])O.[Na+],val
US05750531,CC1NCCc2ccsc21.CCc1nc(Cl)nc(Cl)c1C>>CCc1nc(Cl)nc(N2CCc3ccsc3C2C)c1C,,CN(C)C=O,,CCN(CC)CC,,val
US04599336,CC(C)c1cc(C(C)C)c2nc[nH]c(=O)c2c1.COC(=O)/C=C\Cl>>COC(=O)/C=C/n1cnc2c(C(C)C)cc(C(C)C)cc2c1=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04421757,CNS(=O)(=O)c1cc(-c2csc(=Nc3ccc(O)cc3)n2C)ccc1Cl.Cl>>CNS(=O)(=O)c1cc(-c2csc(=Nc3ccc(O)cc3)n2C)ccc1Cl.Cl,,CO,,,,val
US20120171245A1,COC(=O)C1(C)CCCC(NC(=O)OC(C)(C)C)C1.Fc1cnc(Cl)nc1Cl>>COC(=O)[C@]1(C)CCC[C@H](Nc2nc(Cl)ncc2F)C1,,CO,,CCN(C(C)C)C(C)C,Cl,val
US20030153566A1,COc1ccc(N(C)C2CCOCC2)cc1NC(N)=S>>COc1ccc(N(C)C2CCOCC2)c2sc(N)nc12,,ClC(Cl)Cl,,BrBr,,val
US20090012093A1,CCCNC(N)=S.O=C(CBr)c1ccc(C(F)(F)F)cc1>>Br.CCCNc1nc(-c2ccc(C(F)(F)F)cc2)cs1,,CC(C)OC(C)C,,CCO,,val
US20110190346A1,COC(=O)C(C)(Oc1ccc(C(C)(c2ccc(I)cc2)C(C)C)cc1)c1ccccn1>>CC(C)C(C)(c1ccc(I)cc1)c1ccc(OC(C)(CO)c2ccccn2)cc1,,C1CCOC1,,[BH4-].[Li+],,val
US20040082590A1,CC(COc1ccccc1N1CCN(C(=O)OC(C)(C)C)CC1)NC(=O)OCc1ccccc1>>CC(N)COc1ccccc1N1CCN(C(=O)OC(C)(C)C)CC1,[Pd],CO,,,,val
US04473570,CC1N=Cc2cc(Cl)nc(=O)n21.CCCBr>>CCCn1c(Cl)cc2cnc(C)n2c1=O,,C1COCCO1,,[H-].[Na+],,val
US05130432,O=S(Cl)Cl.OC[C@H]1CCCN1>>O=[S@@]1OCC2CCCN21,,ClCCl,,c1ccncc1,,val
US20100075983A1,COC(=O)C=C1CCC(OC(C)C)CC1>>COC(=O)CC1CCC(OC(C)C)CC1,[Pd],CCOC(C)=O,,,,val
US20090239865A1,CN.O=C(O)c1ccc(Cl)c(Br)c1>>CNC(=O)c1ccc(Cl)c(Br)c1,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US04492711,CN(C)Cc1ccc(CSCCNC(=O)c2cccc(N)c2)o1.CSC(=NC#N)SC>>CSC(=NC#N)Nc1cccc(C(=O)NCCSCc2ccc(CN(C)C)o2)c1,,CCO,,,,val
US20080114022A1,COC(=O)C(=O)c1c(C)[nH]c2nc(Cl)ccc12>>COC(=O)Cc1c(C)[nH]c2nc(Cl)ccc12,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US05610161,Clc1ccc(C2=CCCNC23CCCCC3)cc1>>Clc1ccc(C2=CCCNC23CCCCC3)cc1,,O,,O=S(=O)(O)O,,val
US20150210649A1,CC(C)(Br)C(=O)O.CNC(=O)c1ccc(N)cc1F>>CNC(=O)c1ccc(NC(C)(C)C(=O)O)cc1F,,CCN(CC)CC,,ClCCl,,val
US20150182507A1,CC(C)[Si](Cl)(C(C)C)C(C)C.OCc1cn2ccccc2n1>>CC(C)[Si](OCc1cn2ccccc2n1)(C(C)C)C(C)C,,ClCCl,,O,,val
US20130012491A1,CCOC(=O)CCCc1cccc(-c2cnc(-c3ccc(OC(C)C)c(C(F)(F)F)c3)nc2)c1CC>>CCc1c(CCCC(=O)O)cccc1-c1cnc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)nc1,,CC(C)O,O,[Na+].[OH-],,val
US20030074833A1,CC(C)(C)CC(C)(C)c1cc(-n2nc3ccc(-c4ccc(N)cc4)cc3n2)c(O)c(C(C)(C)c2ccccc2)c1.CC1(C)CCCC(C)(C)N1O>>CC(C)(C)CC(C)(C)c1cc(-n2nc3ccc(-c4ccc(ON5C(C)(C)CCCC5(C)C)cc4)cc3n2)c(O)c(C(C)(C)c2ccccc2)c1,,c1ccncc1,,CC(C)(C)ON=O,,val
US20100261728A1,FC(F)(F)c1ccc([C@H]2NCCc3ccccc32)cc1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20150225379A1,COCC1(CN(C(=O)C(F)(F)F)[C@@H]2C[C@H]2c2ccccc2)CCN(C(=O)OC(C)(C)C)CC1>>COCC1(CN(C(=O)C(F)(F)F)[C@@H]2C[C@H]2c2ccccc2)CCNCC1,,ClCCl,,C1COCCO1,Cl,val
US04927838,CCCCc1c(/C=C/C(=O)O)ccc2ccc(OC)cc12.O=[N+]([O-])c1ccc(O)cc1>>CCCCc1c(/C=C/C(=O)Oc2ccc([N+](=O)[O-])cc2)ccc2ccc(OC)cc12,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100209420A1,CCNc1cc(C)nc(SC)n1.ClI>>CCNc1nc(SC)nc(C)c1I,,CO,,,,val
US20100261755A1,COC(=O)c1ccnc(Cc2ccc(F)cc2)c1>>COC(=O)C1CCNC(Cc2ccc(F)cc2)C1,O=[Pt]=O,CC(=O)O,,,,val
US05834463,Cl.O=C1c2ccccc2C(=O)N1CC(=O)N1c2ccccc2N(Cc2cccnc2)C(=O)[C@H]2CCC[C@H]21>>Cl.O=C1c2ccccc2C(=O)N1CC(=O)N1c2ccccc2N(Cc2cccnc2)C(=O)[C@H]2CCC[C@H]21,,CCO,CCOCC,,,val
US04861798,CCCCOc1ccc(CCCCCCCCC(=O)Cl)cc1.NO>>CCCCOc1ccc(CCCCCCCCC(=O)NO)cc1,,ClCCl,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20050131014A1,Nc1ccccc1.O=C(O)c1cnc2c(C(F)(F)F)cccc2c1-c1ccccc1>>O=C(Nc1ccccc1)c1cnc2c(C(F)(F)F)cccc2c1-c1ccccc1,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20050256201A1,CC1(C)OCc2cc([C@@H]3CN(CCc4ccc(OCCOCc5cccc(SC6CCCC6)c5)cc4)C(=O)O3)ccc2O1.O>>CC1(C)OCc2cc([C@@H]3CN(CCc4ccc(OCCOCc5cccc(S(=O)C6CCCC6)c5)cc4)C(=O)O3)ccc2O1,,CCO,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20090312310A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NN.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)N1CCC[C@H]1c1n[nH]c(=O)o1,,C1CCOC1,CCOC(C)=O,,,val
US20160038504A1,BrCCOCCBr.Nc1cc(Br)cnc1F>>Fc1ncc(Br)cc1N1CCOCC1,,CN(C)C=O,,O,[H-].[Na+],val
US06737425B1,BrCCOc1ccccc1.C1CNCCN1>>c1ccc(OCCN2CCNCC2)cc1,,C1CCOC1,,,,val
US20140045862A1,COc1ccc(CN(C(=O)OC(C)(C)C)S(=O)(=O)c2c(F)cc(O[C@H]3CCC[C@@H]3c3ccnn3C)cc2F)c(OC)c1>>Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(S(N)(=O)=O)c(F)c1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US04456465,CC(C)(C)C(=O)OCCl.CCP(=O)(O)c1cc(Oc2ccc(Cl)cc2Cl)ccc1[N+](=O)[O-]>>CCP(=O)(OCOC(=O)C(C)(C)C)c1cc(Oc2ccc(Cl)cc2Cl)ccc1[N+](=O)[O-],,CN(C)C=O,,CCN(CC)CC,,val
US05599770,COc1cc(Cl)nc(S(C)(=O)=O)n1.OCc1ccccc1>>COc1cc(Cl)nc(OCc2ccccc2)n1,,Cc1ccccc1,,O,[H-].[Na+],val
US20090042854A1,CI.COC(=O)C[C@@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CN1C(=O)OC(C)(C)C>>COC(=O)C(C)[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CN1C(=O)OC(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20090221555A1,CNC(=O)c1ccccc1N.Fc1cnc(Cl)nc1Cl>>CNC(=O)c1ccccc1Nc1nc(Cl)ncc1F,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US05661159,O=Cc1ccc(OCc2ccc3ccccc3n2)c(C=O)c1>>O=Cc1ccc2oc(-c3ccc4ccccc4n3)cc2c1,,CO,,C[O-].[Na+],,val
US20100093706A1,C[C@H]1CC[C@@H](COc2ccc(C(F)(F)F)cc2)CN1C(=O)OC(C)(C)C>>C[C@H]1CC[C@@H](COc2ccc(C(F)(F)F)cc2)CN1,,CO,,CCOCC,Cl,val
US04167628,CCOP(=O)(Cc1ccc(-c2nc3cc(Cl)ccc3o2)cc1)OCC.O=Cc1ccc2nc(-c3ccccc3)oc2c1>>Clc1ccc2oc(-c3ccc(C=Cc4ccc5nc(-c6ccccc6)oc5c4)cc3)nc2c1,,CN(C)C=O,,O,,val
US20140243302A1,O=c1[nH]c2nc(Br)ccc2o1.OB(O)C=Cc1ccccc1>>O=c1oc2cccnc2n1C=Cc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20150031679A1,COC(=O)c1ccc2nc(-c3ccccc3)c(Br)nc2c1.NCCOc1ccccc1Br>>COC(=O)c1ccc2nc(-c3ccccc3)c(NCCOc3ccccc3Br)nc2c1,,CCCCO,,,,val
US20070197604A1,CS(=O)(=O)Cl.Cc1oc(-c2ccc(OCc3ccccn3)cc2)nc1CCO>>Cc1oc(-c2ccc(OCc3ccccn3)cc2)nc1CCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US05114944,Cc1ccc(-c2nn3cccnc3c2CC(=O)n2ccnc2)cc1.N>>Cc1ccc(-c2nn3cccnc3c2CC(N)=O)cc1,,C1CCOC1,O,,,val
US20030004351A1,CCOC=C1C(=O)Nc2ccc3ncsc3c21.Nc1ccc(S(=O)(=O)Nc2ccccn2)cc1>>O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1,,O,,CCO,,val
US20130231328A1,CC1(N=C=O)CCC(OCOCC[Si](C)(C)C)CC1.Cl>>CC1(N)CCC(O)CC1.Cl,,C1CCOC1,,,,val
US20140135381A1,COc1ccc(N(CCCC[C@H](NC(=O)C[C@H](Cc2ccc(F)cc2)NC(=O)CCC(=O)NCCCO[C@H]2CC[C@@]3(C)C(=CC[C@H]4[C@@H]5CC[C@H]([C@H](C)CCCC(C)C)[C@@]5(C)CC[C@@H]43)C2)C(=O)Nc2ccc(CO)cc2)C(c2ccccc2)c2ccccc2)cc1.O=C(Oc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1>>COc1ccc(N(CCCC[C@H](NC(=O)C[C@H](Cc2ccc(F)cc2)NC(=O)CCC(=O)NCCCO[C@H]2CC[C@@]3(C)C(=CC[C@H]4[C@@H]5CC[C@H]([C@H](C)CCCC(C)C)[C@@]5(C)CC[C@@H]43)C2)C(=O)Nc2ccc(COC(=O)Oc3ccc([N+](=O)[O-])cc3)cc2)C(c2ccccc2)c2ccccc2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,ClCCl,val
US20080227839A1,CC(C)(C)C(N)=O.O=C(CBr)c1ccc(F)cc1>>CC(C)(C)c1nc(-c2ccc(F)cc2)co1,,C1COCCO1,,,,val
US20090239854A1,CN1CCC(=O)CC1=O.Cc1ccc(CCBr)cn1.Cc1ccc(NN)cc1>>Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CC(=O)N(C)C1,,CCO,,CCN(CC)CC,Cl,val
US20090082378A1,CC(C)(C)N.O=C(O)c1cccc(S(=O)(=O)Cl)c1>>CC(C)(C)NS(=O)(=O)c1cccc(C(=O)O)c1,,ClCCl,,,,val
US20050282891A1,C[C@@H](OC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)OC(C)(C)C)[C@@H](C)OC(=O)c1ccccc1.Cl>>C[C@@H](OC(=O)[C@@H](N)Cc1ccc(O)c(O)c1)[C@@H](C)OC(=O)c1ccccc1.Cl,,C1COCCO1,,,,val
US20040138065A1,FC(F)(F)CCCI.N#CC(C#N)Cc1ccc(C(F)(F)F)cc1>>N#CC(C#N)(CCCC(F)(F)F)Cc1ccc(C(F)(F)F)cc1,,CN(C)C=O,,[H-].[Na+],,val
US04243609,CCCCCCCCCCCCCCCCNc1ccc(C(=O)NCC(=O)OCC)c(F)c1>>CCCCCCCCCCCCCCCCNc1ccc(C(=O)NCC(=O)O)c(F)c1,,CCO,,[Na+].[OH-],,val
US20140371238A1,Cc1ccc2nc(-c3ccccc3)n(C3CCN(C(=O)OC(C)(C)C)CC3)c2n1>>Cc1ccc2nc(-c3ccccc3)n(C3CCNCC3)c2n1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20040116694A1,CCc1ccc2c(N=CC(O)(CC(C)(C)c3cc(F)ccc3OC)C(F)(F)F)cccc2n1>>CCc1ccc2c(NCC(O)(CC(C)(C)c3cc(F)ccc3O)C(F)(F)F)cccc2n1,,ClCCl,,BrB(Br)Br,CO,val
US20080015199A1,COc1cc(C=O)cc2c1OCC(=O)N2.FCCI>>COc1cc(C=O)cc2c1OCC(=O)N2CCF,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070049593A1,BrCCOC1CCCCO1.Oc1ccccc1OCc1ccccc1>>c1ccc(COc2ccccc2OCCOC2CCCCO2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20100063108A1,CC(C)O.Cc1cc(C(=O)O)cc(Cl)n1>>Cc1cc(C(=O)OC(C)C)cc(Cl)n1,,O=S(=O)(O)O,,,,val
US20050171109A1,CCOC(=O)C(O)CC(C)(C)c1cccc(OC)c1>>CCOC(=O)C(=O)CC(C)(C)c1cccc(OC)c1,,ClCCl,,CCN(CC)CC,CS(C)=O,val
US20150126492A1,COc1cc(C(N)=O)c(NC(N)=O)c(F)c1OC>>COc1cc2c(=O)[nH]c(=O)[nH]c2c(F)c1OC,,[Na+],[OH-],Cl,,val
US20100197651A1,O=c1ccn(-c2cccc(C(F)(F)F)c2)nc1Br.OB(O)c1ccoc1-c1ccccc1>>O=c1ccn(-c2cccc(C(F)(F)F)c2)nc1-c1ccoc1-c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20050245712A1,CCCCCCCCCCCC(=O)Cl.OCC#CC#CCO.[N-]=[N+]=NCCCCCCCCCCC(=O)Cl>>CCCCCCCCCCCC(=O)OCC#CC#CCOC(=O)CCCCCCCCCCN=[N+]=[N-],,C1CCOC1,c1ccncc1,,,val
US20090099156A1,CC(C)(C)OC(=O)N1CCC(C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1>>O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C(=O)C2CCNC2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150315198A1,Cc1cc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nc(C)c1CN>>Cc1cc(N(C)C)nc(C)c1CN,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130035318A1,C=C(C)[C@@H]1CC[C@]2(NCCNS(C)(=O)=O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(NCCNS(C)(=O)=O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1COCCO1,,[Na+].[OH-],,val
US20110263647A1,CC(C)(C)OC(=O)N1[C@@H](Cc2ccc(C(C)(F)F)nc2)COS1=O.COCc1nc(NC(=O)OC(C)(C)C)sc1Br>>COCc1nc(N(C[C@H](Cc2ccc(C(C)(F)F)nc2)NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)sc1Br,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06265423B1,CC1(C)CCC(C)(C)c2cc(CBr)ccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC1(C)CCC(C)(C)c2cc(C[P+](c3ccccc3)(c3ccccc3)c3ccccc3)ccc21.[Br-],,CCOCC,ClCCl,,,val
US20070027178A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc(F)c2c3c([nH]c12)CCNC3>>Cc1ccc(F)c2c3c([nH]c12)CCN(C(=O)OC(C)(C)C)C3,,C1COCCO1,,Cl,[Na+].[OH-],val
US05578620,CC(CO[Si](C)(C)C(C)(C)C)N1CC(COc2cccc(F)c2)OC1=O>>CC(CO)N1CC(COc2cccc(F)c2)OC1=O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150344468A1,C[Si](C)(C)CCOCCl.O=C(c1ccc2[nH]c(=O)sc2c1)c1nc(Br)cs1>>C[Si](C)(C)CCOCn1c(=O)sc2cc(C(=O)c3nc(Br)cs3)ccc21,,C1CCOC1,,[H-].[Na+],,val
US20100280011A1,CC(C)(C)OC(=O)NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(CO)s1.Cl.ClCCl>>Cl.Cl.NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(CO)s1,,ClCCl,,C1COCCO1,,val
US20160257652A1,Cc1ccc(S(=O)(=O)OCC2CC(O)C2)cc1.Cc1nc(O)ccc1Br>>Cc1nc(OCC2CC(O)C2)ccc1Br,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05591743,CI.O=c1cn[nH]c(=S)[nH]1>>CSc1nc(=O)cn[nH]1,,[Na+],[OH-],CC(=O)O,,val
US20100204240A1,Cc1ncccc1Oc1cc(Sc2ccccn2)cnc1Nc1nc([C@@H]2OC(C)(C)OC2(C)C)ns1.Cl>>Cc1ncccc1Oc1cc(Sc2ccccn2)cnc1Nc1nc([C@H](O)C(C)(C)O)ns1.Cl,,CCO,,,,val
US20050277643A1,CC(=O)OC(C)=O.CC1(C)CNCc2cc(N)ccc21>>CC(=O)N1Cc2cc(N)ccc2C(C)(C)C1,,ClCCl,,CCN(CC)CC,,val
US20060100431A1,CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)F.COC1(OC)CN(C(=O)c2ccccc2)[C@@H]2CCN[C@@H]21>>COC1(OC)CN(C(=O)c2ccccc2)[C@@H]2CCN(C(=O)[C@H](CC(C)C)NC(=O)OCc3ccccc3)[C@@H]21,,CN(C)C=O,,,,val
US20090105253A1,C#CC(=O)OCC.CCNC(=O)c1ccc(N=[N+]=[N-])c(O)c1>>CCNC(=O)c1ccc(-n2cc(C(=O)OCC)nn2)c(O)c1,,Cc1ccccc1,,,,val
US05830902,CN1c2ccccc2Sc2cc(CO)ccc21.O=C(OO)c1cccc(Cl)c1>>CN1c2ccccc2S(=O)c2cc(CO)ccc21,,CO,ClC(Cl)Cl,ClCCl,O=C([O-])O.[Na+],val
US20100305113A1,COc1ccc(-c2ccc3nc(C)cn3n2)cc1OC.O=C1CCC(=O)N1Br>>COc1ccc(-c2ccc3nc(C)c(Br)n3n2)cc1OC,,CN(C)C=O,,,,val
US20130102600A1,CC(C)(C)ON.COC(=O)c1ncc(Br)cc1CBr>>COC(=O)c1ncc(Br)cc1CNOC(C)(C)C,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20070099990A1,CI.Cc1cc(C)c(Cc2ccc(C(C)C)cc2)c(O)c1>>COc1cc(C)cc(C)c1Cc1ccc(C(C)C)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20030078282A1,CC(C)Oc1cccc(C2CCN(C(=O)Oc3ccccc3)CC2)c1>>Oc1cccc(C2CCNCC2)c1,,Br,,CC(=O)O,O,val
US20070270398A1,O=C(C1CCNCC1)N1CCOCC1.O=C1CN(C(c2ccccc2)c2ccccc2)C1>>O=C(C1CCN(C2CN(C(c3ccccc3)c3ccccc3)C2)CC1)N1CCOCC1,,CC(=O)O,CO,,,val
US20090093456A1,C=Cc1cc(-c2ccc(Cl)cc2)sc1C(=O)OC.OO>>COC(=O)c1sc(-c2ccc(Cl)cc2)cc1CCO,,C1CCOC1,,B1C2CCCC1CCC2,[Na+].[OH-],val
US20070093508A1,CC(=O)CCl.Nc1nnc(S)s1>>CC(=O)CSc1nnc(N)s1,,CCO,O,[Na+].[OH-],,val
US05547972,CC(=O)Cl.CCC(CC)(NCCCn1cnc(CO)c1)c1ccccc1.ClCCl>>CCC(CC)(NCCCn1cnc(COC(C)=O)c1)c1ccccc1.Cl,,ClCCl,,CCN(CC)CC,,val
US20070129355A1,C1CCNC1.COC(=O)Cc1c(Cl)nc(Cc2ccc(NC(=O)c3ccc4ccccc4c3)cc2)nc1Cl>>COC(=O)Cc1c(Cl)nc(Cc2ccc(NC(=O)c3ccc4ccccc4c3)cc2)nc1N1CCCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20120193577A1,Brc1ccc(C2=CCC3(CC2)OCCO3)cc1.CCOc1ccc(B(O)O)c(F)c1F>>CCOc1ccc(-c2ccc(C3CCC4(CC3)OCCO4)cc2)c(F)c1F,,O,,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20110017986A1,C=CCc1ccc(-c2ccc(C)s2)s1.Cl[SiH](Cl)Cl>>Cc1ccc(-c2ccc(CCC[Si](Cl)(Cl)Cl)s2)s1,[Pt],Cc1ccccc1,,,,val
US05594004,O=C(O)c1ccc(O)c(O)c1.OCc1ccccc1>>O=C(OCc1ccccc1)c1ccc(O)c(O)c1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US04666913,CC(Br)C(=O)Br.O=C1NCc2ccccc2N1>>CC(Br)C(=O)c1ccc2c(c1)CNC(=O)N2,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20060211712A1,Nc1cc(Br)ccc1C(=O)O.O=C(Cl)Cl>>O=c1[nH]c2cc(Br)ccc2c(=O)o1,,C1CCOC1,Cl,,,val
US20160122342A1,C=CCN(C)Cc1cc(C)nc(OC)c1C#N>>C=CCN(C)Cc1cc(C)nc(OC)c1CN,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100249119A1,CC(C)(C#N)c1cccc(C(=O)Cl)c1.Cc1ccc(O)cc1N>>Cc1ccc(O)cc1NC(=O)c1cccc(C(C)(C)C#N)c1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20060100425A1,CC(C)(C)OC(=O)CBr.CCCCN1N=C(c2c(C)[nH]c3ccccc23)C2CC=CCC2C1=O>>CCCCN1N=C(c2c(C)n(CC(=O)O)c3ccccc23)C2CC=CCC2C1=O,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20110028493A1,Cc1sc(C=O)cc1Br>>Cc1sc(CO)cc1Br,,CCO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20090004185A1,CNC.Cl.O=C(Nc1ccc(CNc2nc(Cl)nc3cc(I)ccc23)cc1)c1ccc(Cl)nc1>>CN(C)c1nc(NCc2ccc(NC(=O)c3ccc(Cl)nc3)cc2)c2ccc(I)cc2n1.Cl,,CN(C)C=O,,O,,val
US05134142,CS(=O)(=O)c1ccc(-c2cc(C#N)nn2-c2ccc(F)cc2)cc1.[N-]=[N+]=[N-]>>CS(=O)(=O)c1ccc(-c2cc(-c3nnn[nH]3)nn2-c2ccc(F)cc2)cc1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20030144338A1,CCCCCc1ccc(CCCOS(C)(=O)=O)cc1.O=C1NC(=O)c2ccccc21>>CCCCCc1ccc(CCCN2C(=O)c3ccccc3C2=O)cc1,,CN(C)C=O,,[K],,val
US20060135512A1,CC(C)(C)OC(=O)N[C@@H]1CCCC[C@H]1n1ccc(C=O)c1.C[Mg]Cl>>CCc1ccn([C@@H]2CCCC[C@H]2NC(=O)OC(C)(C)C)c1,,C1CCOC1,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20070060629A1,CC1(O)ON=C(c2cccnc2)C1c1ccc(Br)cc1>>Cc1onc(-c2cccnc2)c1-c1ccc(Br)cc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US07247645B2,CC(=O)CC(=O)OCCC#N.O=Cc1cccc(Cl)c1>>CC(=O)C(=Cc1cccc(Cl)c1)C(=O)OCCC#N,,CC(C)O,,C1CCNCC1,CC(=O)O,val
US20140315888A1,CN1CCNCC1.Cc1nc2c(Cl)nc3ncc(Cl)cc3n2n1>>Cc1nc2c(N3CCN(C)CC3)nc3ncc(Cl)cc3n2n1,,CN(C)C=O,,O=C(O)C(F)(F)F,,val
US20070060587A1,CCOC(=O)N=NC(=O)OCC.O=C1NC(=O)c2ccccc21.OCCCc1ccccn1>>O=C1c2ccccc2C(=O)N1CCCc1ccccn1.[NH4+].[OH-],,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040171633A1,Brc1ccccn1.OB(O)c1ccccc1F>>Fc1ccccc1-c1ccccn1,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20120202785A1,C[C@H](N)c1nc2cccnc2n1-c1ccccc1.N#Cc1c(N)ncnc1Cl>>CC(Nc1ncnc(N)c1C#N)c1nc2cccnc2n1-c1ccccc1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20110237517A1,CC(C)(C)OC(=O)N1CCC(OS(C)(=O)=O)C1CCNC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC2C1CCN2C(=O)OCc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20060189663A1,NCc1cccnc1.O=C1OC(=O)C(c2ccccc2)=C1Cl>>O=C1C(Cl)=C(c2ccccc2)C(=O)N1Cc1cccnc1,,CC(=O)O,,,,val
US20080009530A1,CC(C)Oc1cc(CCC(=O)O)n(Cc2ccc(Cl)cc2Cl)n1.NS(=O)(=O)Cc1ccccc1>>CC(C)Oc1cc(CCC(=O)NS(=O)(=O)Cc2ccccc2)n(Cc2ccc(Cl)cc2Cl)n1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20100080770A1,C=CCc1c(OC)ccc2ccc(Br)cc12.COC(=O)[C@@H]1CC(=O)CN1C(=O)OCC[Si](C)(C)C>>C=CCc1c(OC)ccc2ccc([C@]3(O)C[C@@H](C(=O)OC)N(C(=O)OCC[Si](C)(C)C)C3)cc12,,C1CCOC1,ClCCl,[Mg],,val
US20160185779A1,C=CCn1nc2c(c1-c1ccccc1)CN(C(=O)COc1ccccc1)CC2>>CCCn1nc2c(c1-c1ccccc1)CN(C(=O)COc1ccccc1)CC2,[Pd],CO,,,,val
US03966930,CN(C)S(=O)(=O)c1ccc2c(c1)Nc1ccc(F)cc1S2.CN1CCN(CCCCl)CC1>>CN1CCN(CCCN2c3ccc(F)cc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20080194617A1,CCOC(=O)CP(=O)(OCC)OCC.Cc1cnc2c(ccn2-c2c(C=O)c(C)nn2C)c1>>CCOC(=O)/C=C/c1c(C)nn(C)c1-n1ccc2cc(C)cnc21,,C1CCOC1,,O,[H-].[Na+],val
US20120208819A1,CNc1ccc(Cl)nc1.C[C@H](NC(=O)c1cc(C#N)cnc1F)c1ccc(F)cc1>>C[C@H](NC(=O)c1cc(C#N)cnc1NCc1ccc(Cl)nc1)c1ccc(F)cc1,,CCOC(C)=O,CS(C)=O,CCN(C(C)C)C(C)C,,val
US06355642B1,BrCCCCBr.O=C1Nc2cccc3c2C1CCC3>>O=C1Nc2cccc3c2C1(CCCCBr)CCC3,,CN(C)C=O,,[H-].[Na+],,val
US05872131,COc1cc(C(=O)CCCN2CCC(O)CC2)cc(OC)c1OC.Nc1c(Cl)cc(C(=O)O)c2c1CCCO2>>COc1cc(C(=O)CCCN2CCC(OC(=O)c3cc(Cl)c(N)c4c3OCCC4)CC2)cc(OC)c1OC,,C1CCOC1,CC#N,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20100087429A1,COC(C)(C)COc1cnc2c(c1)C1(COC(N)=N1)c1cc(Br)ccc1O2.OB(O)c1cccnc1F>>COC(C)(C)COc1cnc2c(c1)C1(COC(N)=N1)c1cc(-c3cccnc3F)ccc1O2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US20100330199A1,C#Cc1nc(C(=O)OCC)c(O)c2c(-c3ccc(Cl)cc3)nsc12.[N-]=[N+]=NCc1ccccc1>>CCOC(=O)c1nc(-c2cn(Cc3ccccc3)nn2)c2snc(-c3ccc(Cl)cc3)c2c1O,,CCO,ClCCl,O=C(CO)O[CH][C@@H](O)CO,C[O-].[Na+],val
US20120107307A1,Cn1c(N(C(=O)OC(C)(C)C)c2ccc(I)cc2F)c(NS(=O)(=O)C2(CC=O)CC2)ccc1=O>>Cn1c(N(C(=O)OC(C)(C)C)c2ccc(I)cc2F)c(NS(=O)(=O)C2(CCO)CC2)ccc1=O,,CO,,[BH4-].[Na+],,val
US20040082575A1,Cc1ccc(CC(=O)O)cc1.O=[N+]([O-])O>>Cc1ccc(CC(=O)O)cc1[N+](=O)[O-],,ClCCl,,,,val
US05574042,Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)C=Cc4ccc(NC(=O)CCC(=O)O)cc4)c3Cl)cccn2c1Br>>Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)C=Cc4ccc(N5C(=O)CCC5=O)cc4)c3Cl)cccn2c1Br,,CC(=O)OC(C)=O,,CC(=O)[O-].[Na+],,val
US20140213599A1,C[C@H]1Cn2c(cc(Cl)nc2=O)N1C(=O)OC(C)(C)C.OCc1ccc(F)c(F)c1>>C[C@H]1Cn2c(cc(OCc3ccc(F)c(F)c3)nc2=O)N1,,C1CCOC1,,[H-].[Na+],,val
US04161598,CCCC1=C(C)C(Cc2ccc(OC)cc2)N(Cc2ccccc2)CC1.O=C(O)C(=O)O>>CCCC1=C(C)C(Cc2ccc(OC)cc2)NCC1.O=C(O)C(=O)O,[Pd],CCO,,,,val
US20150023913A1,C[C@]1(COC(=O)c2ccccc2)CCCC(O)CO1>>C[C@]1(COC(=O)c2ccccc2)CCCC(=O)CO1,,CCCCCC,ClCCl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20150344468A1,CC(c1ccc2c(c1)sc(=O)n2COCC[Si](C)(C)C)c1ccn(-c2ccc(O)cn2)n1.COC(=O)C(C)(C)CO>>COC(=O)C(C)(C)COc1ccc(-n2ccc(C(C)c3ccc4c(c3)sc(=O)n4COCC[Si](C)(C)C)n2)nc1,,C1COCCO1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110178117A1,CCCCCCC(=O)Cn1c(Cl)nc2ccccc21.C[Mg]Br>>CCCCCCC1(C)Cn2c(nc3ccccc32)O1,,C1CCOC1,,,,val
US20030078251A1,CCOC(=O)c1cc2cc([N+](=O)[O-])cc(OC)c2o1>>O=C(O)c1cc2cc([N+](=O)[O-])cc(O)c2o1,,CC(=O)O,,Br,O,val
US20120122843A1,CC(NCC(O)C1CC1)c1ccc(Cl)nc1Cl>>CC1NCC(C2CC2)Oc2nc(Cl)ccc21,,C1CCOC1,,[H-].[Na+],,val
US06054588,BrCc1ccccc1.O=C(Cn1cncn1)c1ccc(Cl)cc1Cl>>Clc1ccc(C(=Cn2cncn2)OCc2ccccc2)c(Cl)c1,,C1CCOC1,CN1CCCN(C)C1=O,[H-].[Na+],,val
US20120028994A1,COC(=O)C1CCC(c2ccccc2OC)C1=O.NC(N)=O>>COc1ccccc1C1CCc2c(O)nc(O)nc21,,O,,CO,,val
US04629736,CCCCCCCCCCCCCCCC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1)OC(=O)CCCCCNC(=O)CCCCCNC(C)=O>>CCCCCCCCCCCCCCCC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)O)OC(=O)CCCCCNC(=O)CCCCCNC(C)=O,[Pd],C1CCOC1,CO,,,val
US20090286840A1,COC(=O)c1sc(-n2ccnc2)cc1OC(C)c1ccccc1Cl.N>>CC(Oc1cc(-n2ccnc2)sc1C(N)=O)c1ccccc1Cl,,CO,,CCOCC,,val
US20060252751A1,O=C(c1cnc(C2(Cl)CCC3(CC2)OCCO3)s1)N1CCCC1>>O=C(c1cnc(C2CCC3(CC2)OCCO3)s1)N1CCCC1,[Pd],CO,,,,val
US20160200704A1,CC(C)(C)NC(=O)O.CC(C)(C)NC(=O)O.Nc1noc2ccc(CBr)cc12.O=C1NC(=O)c2ccccc21>>CC(C)(C)NC(=O)O.CC(C)(C)NC(=O)O.Nc1noc2ccc(CN3C(=O)c4ccccc4C3=O)cc12,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04329353,COc1ccc(C2(C(=O)O)CCC3(CC2)OCCO3)cc1.O=S(Cl)Cl>>COc1ccc(C2(C(=O)Cl)CCC3(CC2)OCCO3)cc1,,c1ccccc1,,,,val
US04738970,C=CCOc1c(C)c[n+]([O-])c2c1CCCC2.CC(=O)OC(C)=O>>C=CCOc1c(C)cnc2c1CCCC2OC(C)=O,,O,,,,val
US20090239854A1,C=Cc1cnc(NC(C)=O)c(C)c1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>CC(=O)Nc1ncc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1C,,CN1CCCC1=O,,[K+].[OH-],,val
US20160060260A1,BrBr.Cn1c(=O)n(C)c2cc(N)ccc21>>Cn1c(=O)n(C)c2cc(Br)c(N)cc21,,CC(=O)O,ClC(Cl)Cl,,,val
US20020188125A1,C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CC#N.CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CCOC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)Cn1cnc2c(=O)[nH]c(N)nc21.CN(C)c1ccncc1.CO>>CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O.CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CCOC(=O)[C@@H](N)C(C)C)Cn1cnc2c(=O)[nH]c(N)nc21,CN(C)c1ccncc1,C1CCOC1,CO,,,val
US20070049632A1,Cn1c2c(c(=O)n1Cc1cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)nc1C(F)(F)F)[C@H]1CC[C@]2(C)C1(C)C>>Cn1c2c(c(=O)n1Cc1c[nH]nc1C(F)(F)F)[C@H]1CC[C@]2(C)C1(C)C,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20020169191A1,CC(=O)OC(C)=O.CS(=O)c1ccc(N2C[C@H](CN)OC2=O)cc1F>>CC(=O)NC[C@H]1CN(c2ccc(S(C)=O)c(F)c2)C(=O)O1,,ClCCl,,c1ccncc1,,val
US20090197834A1,CC1(C)OC(=O)[C@@H](CC(=O)Nc2cn(C3CCCC3)c3cc(NC4CCCCC4)c(F)cc3c2=O)O1>>O=C(C[C@@H](O)C(=O)O)Nc1cn(C2CCCC2)c2cc(NC3CCCCC3)c(F)cc2c1=O,,C1CCOC1,,Cl,[Na+].[OH-],val
US20100234351A1,COC(=O)C1=Cc2c(Nc3ccc(Oc4cccc(C(F)(F)F)c4)c(Cl)c3)ncnc2N(Cc2ccc(OC)cc2)CC1>>COC(=O)C1=Cc2c(ncnc2Nc2ccc(Oc3cccc(C(F)(F)F)c3)c(Cl)c2)NCC1,,ClCCCl,,O=C(O)C(F)(F)F,,val
US07375115B2,COCOCC(CCC1(CCN2CCC(N(C(=O)c3ccco3)c3ccc(C)cn3)CC2)CCCCC1)COCOC>>Cc1ccc(N(C(=O)c2ccco2)C2CCN(CCC3(CCC(CO)CO)CCCCC3)CC2)nc1,,CO,,Cl,,val
US20160151375A1,CC1(C)CCC(O)CC1.CS(=O)(=O)Cl>>CC1(C)CCC(OS(C)(=O)=O)CC1,,ClCCl,,CCN(CC)CC,,val
US20080139595A1,C[Si](C)(C)CCOCn1cc(Br)c2c(Oc3c(F)cc(NC(=O)C(F)(F)F)cc3F)ccnc21>>Nc1cc(F)c(Oc2ccnc3[nH]cc(Br)c23)c(F)c1,,C1COCCO1,O,Cl,[Li+].[OH-],val
US05929085,NOC1=CCCCCC1.O=C1Cc2ccccc2C(=O)O1>>O=c1c2ccccc2cc2n1CCCCC2,,ClC(Cl)Cl,,Cc1ccccc1,,val
US20010006973A1,CC1(N)CCC(=O)NC1=O.Cc1cccc2c1C(=O)OC2=O>>Cc1cccc2c1C(=O)N(C1(C)CCC(=O)NC1=O)C2=O,,CC(=O)O,,Cl,CC(=O)[O-].[Na+],val
US20030195208A1,O=C(OCc1ccc(F)cc1)c1ccc(OCc2ccc(F)cc2)cc1C(=O)OCc1ccc(F)cc1>>O=C(O)c1ccc(OCc2ccc(F)cc2)cc1C(=O)O,,C1CCOC1,O,,,val
US04290953,CCOC(=O)c1ccc2c(c1)NCc1ccccc1O2>>O=C(O)c1ccc2c(c1)NCc1ccccc1O2,,O,,CO,[K+].[OH-],val
US20080171754A1,Nc1ccc(OCc2ccccc2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.Oc1ccccc1C1CC(c2cccnc2)=NN1>>O=C(Nc1ccccc1OCc1ccccc1)N1N=C(c2cccnc2)CC1c1ccccc1O,,CN(C)C=O,ClCCCl,CCN(C(C)C)C(C)C,Cl,val
US05326837,C=Cc1ccc(C)cc1.C=Cc1ccccc1>>C=Cc1ccc(C)cc1.C=Cc1ccccc1,,CC(C)O,,Cc1ccccc1,,val
US20120202776A1,COc1cc(N2CCC(N3CCP(C)(=O)CC3)CC2)ccc1[N+](=O)[O-]>>COc1cc(N2CCC(N3CCP(C)(=O)CC3)CC2)ccc1N,[Pd],CCO,,,,val
US20060194807A1,N#Cc1cccc(F)c1F.c1ccc(-c2cc[nH]n2)nc1>>N#Cc1cc(F)cc(-n2ccc(-c3ccccn3)n2)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130190318A1,CON(C)C(=O)c1ccn(S(=O)(=O)N(C)C)n1.Clc1cccc([Mg]Br)c1>>CN(C)S(=O)(=O)n1ccc(C(=O)c2cccc(Cl)c2)n1,,C1CCOC1,,,,val
US20070197512A1,CC(C)C1Sc2ccccc2NC1=O.COC(=O)CBr>>COC(=O)CN1C(=O)C(C(C)C)Sc2ccccc21,,CN(C)C=O,,Cl,[H-].[Na+],val
US06562823B1,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.N#Cc1ccc(C=O)cc1F>>CCOC(=O)/C=C/c1ccc(C#N)c(F)c1,,Cc1ccccc1,,,,val
US20160237081A1,COC(=O)C(C)c1ccc(F)cc1>>CC(CO)c1ccc(F)cc1,,C1CCOC1,,[BH4-].[Na+],,val
US04088771,CN1C(N)=NCC1c1ccccc1.COC(=O)Cl>>COC(=O)NC1=NCC(c2ccccc2)N1C,,CC(C)=O,,Br,O=C([O-])O.[Na+],val
US20090298827A1,COc1ccccc1NCc1c(-c2ccc(O)cc2OC)ccc2c1C(C)=CC(C)(C)N2.Cc1ncccc1C(=O)O>>COc1ccccc1NCc1c(-c2ccc(OC(=O)c3cccnc3C)cc2OC)ccc2c1C(C)=CC(C)(C)N2,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20030186969A1,C1CCNC1.O=C(O)c1ccc(CN2C(=O)CN(C(=O)c3ccc(Cl)cc3)Cc3ccccc32)cc1>>O=C(c1ccc(CN2C(=O)CN(C(=O)c3ccc(Cl)cc3)Cc3ccccc32)cc1)N1CCCC1,,ClCCl,,CCN(CC)CC,,val
US20140018313A1,COc1cccc(O)c1.Clc1ccc(Br)c(CBr)c1>>COc1cccc(OCc2cc(Cl)ccc2Br)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06083961,CC(=O)Cl.CCNc1cccc(OCc2ccccc2)c1[N+](=O)[O-]>>CCN(C(C)=O)c1cccc(OCc2ccccc2)c1[N+](=O)[O-],,ClCCl,,CCN(CC)CC,,val
US20150336979A1,Cc1ccc(S(=O)(=O)O[C@@H]2CO[C@@H]3[C@@H](NCc4ccccc4)CO[C@H]23)cc1.Oc1ccc(F)cc1>>Fc1ccc(O[C@H]2CO[C@@H]3[C@@H](NCc4ccccc4)CO[C@H]23)cc1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US04390618,CCCCCCCCCCCCOCCCN.CCOC(=O)COc1cc(C(=O)Oc2ccc([N+](=O)[O-])cc2)c(O)c2ccccc12>>CCCCCCCCCCCCOCCCNC(=O)c1c(OC=C=O)c(OCC)c2ccccc2c1O,,CCOC(C)=O,,C1CCOC1,O,val
US20060058324A1,Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@@H]1CC[C@@H](O)CC1>>Cc1ccc(S(=O)(=O)O[C@@H]2CC[C@@H](n3cc(-c4cccc(OCc5ccccc5)c4)c4c(N)ncnc43)CC2)cc1,,ClCCl,,,,val
US20150175621A1,CC(C)(C)OC(=O)N1CCC(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)nc2)CC1.O=C(O)C(F)(F)F>>O=C(NCc1ccc(S(=O)(=O)C2CCNCC2)cn1)c1cc2ccncc2o1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20020183361A1,CC[C@H](C)[C@H](N)CO.O=S(=O)(Cl)c1cccs1>>CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1cccs1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140107194A1,CCI.O=C(O)c1ccc(C[C@@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@H]2O)cc1>>CCOC(=O)c1ccc(C[C@@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@H]2O)cc1,,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],,val
US04677129,CCCCCCCCCCN1C(=O)C2CC(c3ccc([N+](=O)[O-])cc3)(C2)C1=O>>CCCCCCCCCCN1C(=O)C2CC(c3ccc(N)cc3)(C2)C1=O,[Pd],COCCO,,CCCCCC,CCOC(C)=O,val
US20080280875A1,CC1(C)Cc2c(Oc3ccc(S(C)(=O)=O)cc3)cc(C(=O)Nc3ccc(C(C)(C)O[SiH2]C(C)(C)C)cn3)cc2O1>>CC1(C)Cc2c(Oc3ccc(S(C)(=O)=O)cc3)cc(C(=O)Nc3ccc(CO)cn3)cc2O1,,ClCCl,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20070281954A1,CN(C)C1(c2ccccc2)CCC(NC(=O)COc2cccc(Cl)c2)CC1.C[Si](C)(C)Cl>>CN(C)C1(c2ccccc2)CCC(NC(=O)COc2cccc(Cl)c2)CC1.Cl,,CCOC(C)=O,,O,,val
US04213985,O=C(Cl)CCCl.O=C1Nc2cccnc2Nc2ccccc21>>O=C1Nc2cccnc2N(C(=O)CCCl)c2ccccc21,,C1COCCO1,,,,val
US20120040985A1,COc1cc(C(C)(C)c2cnc(SCc3c(F)cc(NC(=O)OC(C)(C)C)cc3F)n2-c2ccc(F)cc2)ccc1Cl>>COc1cc(C(C)(C)c2cnc(SCc3c(F)cc(N)cc3F)n2-c2ccc(F)cc2)ccc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040110804A1,C=O.CNC(=O)c1ccc(CN(OC)C(=O)C=C2OC(C)(C)OC2=O)cc1.NCCN1CCOCC1>>CNC(=O)c1ccc(CN(OC)C(=O)C2=C(O)C(=O)N(CCN3CCOCC3)C2)cc1,,CO,,,,val
US20140011800A1,NC(=O)c1cnn2cc(Br)cc2c1N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1CF>>NC(=O)c1cnn2cc(Br)cc2c1N[C@@H]1CNC[C@@H]1CF,,CC#N,,C[Si](C)(C)I,,val
US20110293520A1,CC(=O)c1ccc2c(c1)OCO2.COC(=O)c1cccc(Br)c1>>O=C(CC(=O)c1ccc2c(c1)OCO2)c1cccc(Br)c1,,CS(C)=O,,[H][H],[H-].[Na+],val
US20090028787A1,CC(C)(C)OC(=O)N1CCN(c2ccc(-c3nc4ccc(N)cc4s3)cn2)CC1>>Nc1ccc2nc(-c3ccc(N4CCNCC4)nc3)sc2c1,,ClCCl,,Cl,O=C(O)C(F)(F)F,val
US05932582,Cc1cc(OCC(N)=O)ccc1NC(=O)OC(C)(C)C>>Cc1cc(OCC(N)=O)ccc1N,,O=C(O)C(F)(F)F,,,,val
US20120077793A1,CC(C)OC(=O)N1CCC(Oc2ccc(Br)cn2)CC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(C)OC(=O)N1CCC(Oc2ccc(B3OC(C)(C)C(C)(C)O3)cn2)CC1,,C1COCCO1,,CC(=O)[O-].[K+],,val
US05095038,O=C1CCc2ccc(NC(=O)C(F)(F)F)cc21>>O=C(Nc1ccc2c(c1)C(O)CC2)C(F)(F)F,[Pd],CN(C)C=O,,CCOC(C)=O,,val
US20160272611A1,CC1COc2c(Cl)cc([Sn](C)(C)C)cc2C1.Cc1ccccc1.O=C([O-])[C@H]1C[C@@H]1C(=O)Cl>>COC(=O)[C@H]1C[C@@H]1C(=O)c1cc(Cl)c2c(c1)CC(C)CO2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,,,val
US04753936,CC(=O)CC(=O)N1CCN(C2CCCCC2)CC1.N>>C/C(N)=C/C(=O)N1CCN(C2CCCCC2)CC1,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04370337,Clc1ccc(C=NNC2=NOCc3ccccc32)cc1>>OCc1ccccc1-c1nc(-c2ccc(Cl)cc2)n[nH]1,,CCO,,,,val
US20020032186A1,CCOC(=O)C(C)(Cc1ccccc1)S(=O)(=O)c1cccs1>>CC(Cc1ccccc1)(C(=O)O)S(=O)(=O)c1cccs1,,CCO,,[Na+].[OH-],,val
US20060148858A1,CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.CCOC(=O)Cc1cccc(O)c1F>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1cccc(CC(=O)O)c1F,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20130217715A1,COCN(c1cccc(-c2nn(C3CCN(C)CC3)cc2-c2ccncc2)c1F)S(=O)(=O)c1cc(F)ccc1F>>CN1CCC(n2cc(-c3ccncc3)c(-c3cccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)n2)CC1,,O,O=C(O)C(F)(F)F,,,val
US20030203946A1,COC(C)(C)n1nnc(C)n1.CON(C)C(=O)c1ccc(CN[C@@H]2CC[C@@H](C(C)(C)C)CC2)cc1>>COC(C)(C)n1nnc(CC(=O)c2ccc(CNC3CCC(C(C)(C)C)CC3)cc2)n1,,C1CCOC1,,[Li]CCCC,,val
US20080058383A1,CC[C@H](N)CO.Cc1cc(F)ccc1[N+](=O)[O-]>>CC[C@@H](CO)Nc1ccc([N+](=O)[O-])c(C)c1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20160108036A1,O=c1ccccn1Cc1ccc(CO)cc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=NCc1ccc(Cn2ccccc2=O)cc1,,CCOC(C)=O,CN(C)C=O,C1CCC2=NCCCN2CC1,,val
US20060035912A1,Cc1cc(C(=O)c2cn(C(C)C)c3ncnc(N)c23)cc(N)n1.O=S(=O)(Cl)c1ccccc1F>>Cc1cc(C(=O)c2cn(C(C)C)c3ncnc(N)c23)cc(NS(=O)(=O)c2ccccc2F)n1,,c1ccncc1,,,,val
US20140038963A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCCCCc1c(C)[nH]c(C)c([N+](=O)[O-])c1=O>>CCCCCCCc1c(C)nc(C)c([N+](=O)[O-])c1OC(=O)OC(C)(C)C,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20150225412A1,CC(C)(C)OC(=O)N1CCC[C@@H]1CN.COC(=O)c1ccc(F)c([N+](=O)[O-])c1>>COC(=O)c1ccc(NC[C@H]2CCCN2C(=O)OC(C)(C)C)c([N+](=O)[O-])c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20090291915A1,COC(=O)c1ccc(Br)o1.C[Si](C)(C)c1cncc(O)c1>>COC(=O)c1ccc(Oc2cncc([Si](C)(C)C)c2)o1,,C1CCOC1,CCOC(C)=O,O,CC(C)(C)[O-].[K+],val
US20140094607A1,CC[SiH](CC)CC.c1ccc2sccc2c1>>CC[Si](CC)(CC)c1csc2ccccc12,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US06511974B1,O=C(c1ccc(F)cc1Cl)N1Cc2cccn2Cc2ccccc21.c1cc[nH]c1>>O=C(c1ccc(-n2cccc2)cc1Cl)N1Cc2cccn2Cc2ccccc21,,CN(C)C=O,,CCCCCC,[H-].[Na+],val
US20160145244A1,Cc1cc(Nc2ncnc(Nc3ccccc3S(=O)(=O)C(C)C)n2)c2c(c1C1CCNCC1)C[C@@H](C)O2.O=C(O)CO>>Cc1cc(Nc2ncnc(Nc3ccccc3S(=O)(=O)C(C)C)n2)c2c(c1C1CCN(C(=O)CO)CC1)C[C@@H](C)O2,,CN(C)C=O,,CCN=C=NCCCN(C)C,,val
US20150252032A1,N#Cc1cccc(F)c1Br.OB(O)c1ccn[nH]1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>N#Cc1cccc(F)c1-c1ccc[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])O.[Na+],,val
US04980349,Clc1cccc(Cl)c1.O=C(Cl)c1cc([N+](=O)[O-])ccc1Cl>>O=C(c1ccc(Cl)cc1Cl)c1cc([N+](=O)[O-])ccc1Cl,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US09272983B2,C=CC[C@@H](C)[C@@H](C(=O)OC)N1C(=O)c2ccccc2C1=O>>C=CC[C@@H](C)[C@H](N)C(=O)O,,CC(=O)O,Cl,,,val
US20130261125A1,CC(C)(C)OC(=O)NC1CCCC(CO)C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)NC1CCCC(COS(C)(=O)=O)C1,,ClCCl,,CCN(CC)CC,,val
US20050187408A1,O=C(Cl)C(=O)Cl.O=S(=O)(O)Cc1ccccc1OCc1ccccc1>>O=S(=O)(Cl)Cc1ccccc1OCc1ccccc1,CN(C)C=O,C1CCOC1,,,,val
US04112095,O=C1CCC(c2ccc(Br)cc2)=NN1>>O=c1ccc(-c2ccc(Br)cc2)n[nH]1,,CC(=O)O,,BrBr,,val
US04294960,CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12)c1csc(NC=O)n1.Cl>>CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12)c1csc(N)n1.Cl,,CO,,,,val
US20130116263A1,CCN.CCOC(=O)c1cnc(Cl)nc1Cl>>CCNc1nc(Cl)ncc1C(=O)OCC,,ClCCl,,CCN(CC)CC,,val
US20030125377A1,COc1ccc(CCCc2ccc(O)cc2)c(O)c1>>Oc1ccc([C@@H]2CCc3ccc(O)cc3O2)cc1,,CO,,[Cl-].[Na+],,val
US06613803B1,NNC(N)=O.O=Cc1ccc(Oc2cc(Cl)ccn2)cc1>>NC(=O)NN=Cc1ccc(Oc2cc(Cl)ccn2)cc1,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20130289033A1,N#Cc1ccc(B(O)O)cc1.O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccccc1I>>N#Cc1ccc(-c2ccccc2C(=O)NCCc2c[nH]c3ccc(Cl)cc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20080058304A1,CCC(O)CN(CC(=O)OC(C)(C)C)C(c1ccccc1)c1ccccc1.O=S(Cl)Cl>>CCC(Cl)CN(CC(=O)OC(C)(C)C)C(c1ccccc1)c1ccccc1,,ClC(Cl)Cl,,,,val
US20120129851A1,NC(N)=O.Nc1cc(Br)ccc1C(=O)O>>O=c1[nH]c(=O)c2ccc(Br)cc2[nH]1,,O,,,,val
US20100331314A1,Nc1cccc(OCCN2CCOCC2)c1.O=Cc1cnn2ccc(Cl)nc12>>O=Cc1cnn2ccc(Nc3cccc(OCCN4CCOCC4)c3)nc12,,C1COCCO1,,ClCCl,,val
US20030092712A1,COc1ccc(CCl)cc1.O=C1NCc2c(-c3ccccc3Cl)cc(C3CCC4(CC3)OCCO4)cc2N1c1c(Cl)cccc1Cl>>COc1ccc(CN2Cc3c(-c4ccccc4Cl)cc(C4CCC5(CC4)OCCO5)cc3N(c3c(Cl)cccc3Cl)C2=O)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20160046630A1,CC(=O)OC(C)=O.Clc1ccc(-n2c(-c3ccccc3Cl)nc3c(N[C@H]4CCCNC4)ncnc32)cc1>>CC(=O)N1CCC[C@H](Nc2ncnc3c2nc(-c2ccccc2Cl)n3-c2ccc(Cl)cc2)C1,,c1ccncc1,,,,val
US20110028469A1,COC(=O)c1sccc1N.Cc1ccc(S(=O)(=O)Cl)c(F)c1>>COC(=O)c1sccc1NS(=O)(=O)c1ccc(C)cc1F,,O,c1ccncc1,,,val
US20120323035A1,CC(C)OC(=O)Oc1ccccc1C(=O)O.O=S(Cl)Cl>>CC(C)OC(=O)Oc1ccccc1C(=O)Cl,c1ccncc1,ClCCl,,,,val
US06258953B1,CC(=O)N(Cc1ccc(Cl)cc1)C(=O)Cc1ccccc1.CN1CCN(c2ccccc2C=O)CC1>>CN1CCN(c2ccccc2C=CC(=O)NCc2ccc(Cl)cc2)CC1,,CCOC(C)=O,,CN(C)C=O,,val
US20040116687A1,CC(C)N(C(C)C)P(Cl)N(C(C)C)C(C)C.ClP(Cl)Cl>>CC(C)N(C(C)C)P(Cl)Cl,,CC#N,,,,val
US20090163586A1,O=C1Nc2ccc(Oc3ccccc3)cc2S(=O)(=O)N1>>Nc1ccc(Oc2ccccc2)cc1S(N)(=O)=O,,O=S(=O)(O)O,,[Na+].[OH-],,val
US20020156081A1,COc1cc(-c2nn(C3CCN(C4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1N.O=C(Cl)c1ccc(OC(F)(F)F)cc1>>COc1cc(-c2nn(C3CCN(C4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)c1ccc(OC(F)(F)F)cc1,,ClCCl,c1ccncc1,,,val
US20070249670A1,COC(=O)[C@@H](NC(=O)c1nc2ccccc2cc1N)C1CCCCC1.Cc1cc(C)c(N=C=O)c(C)c1>>COC(=O)[C@@H](NC(=O)c1nc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C)C1CCCCC1,,c1ccncc1,,,,val
US20040209921A1,C[Si](C)(C)N=C=O.Cc1cnc(CN(Cc2ncccc2C(C)C)C2CCNCC2)c(C)c1>>Cc1cnc(CN(Cc2ncccc2C(C)C)C2CCN(C(N)=O)CC2)c(C)c1,,CC(C)O,,,,val
US20100292279A1,COC(=O)c1ccc(OCc2ccccc2)c(O)c1.OCC1CC1>>COC(=O)c1ccc(OCc2ccccc2)c(OCC2CC2)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090023703A1,CC(C)(C)O.CC(C)(C)OC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)O>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20140179946A1,CC/C=C\CCOC(=O)c1ccccc1>>CCCCCCOC(=O)c1ccccc1,,C1CCOC1,,[H][H],,val
US20140113882A1,CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)[C@@H](C(O)c2ccccc2)C1.CCN(CC)S(F)(F)F>>CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)[C@@H](C(F)c2ccccc2)C1,,ClC(Cl)Cl,,,,val
US20100029657A1,C=O.c1cc(-c2cc3nccc(-c4ccc(N5C[C@@H]6C[C@H]5CN6)nc4)n3n2)ccn1>>CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3cc(-c4ccncc4)nn23)cn1,,CN(C)C=O,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04107307,CCOC(=O)NN.O=Cc1c[nH]c(Cc2ccccc2)n1>>CCOC(=O)NN=Cc1c[nH]c(Cc2ccccc2)n1,CC(=O)O,CCO,,,,val
US20110003793A1,CCCCOC(=O)N1CCCc2c(c3ccc(-n4ccc(OCc5ccc(Cl)cc5)cc4=O)cc3n2C)C1.ClCCl>>Cl.Cn1c2c(c3ccc(-n4ccc(OCc5ccc(Cl)cc5)cc4=O)cc31)CNCCC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080227823A1,CC(C)(C)OC(=O)N1CCC(N)(C(=O)NCCc2c[nH]c3ccc(F)cc23)CC1.O=C(O)/C=C/c1ccc(F)c(Br)c1>>CC(C)(C)OC(=O)N1CCC(NC(=O)/C=C/c2ccc(F)c(Br)c2)(C(=O)NCCc2c[nH]c3ccc(F)cc23)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150018422A1,CCC(C)(C)C(O)c1cc(OCc2ccc(OC)cc2)ccc1-c1cc(OC)ccc1F.CI>>CCC(C)(C)C(OC)c1cc(OCc2ccc(OC)cc2)ccc1-c1cc(OC)ccc1F,,CN(C)C=O,,[Na+].[OH-],,val
US20130165464A1,COC(=O)Nc1cc(-n2cc(-c3ncn(COCC[Si](C)(C)C)n3)c(-c3cc(CN4CCCC4)ccc3Cl)n2)c(C)cn1>>COC(=O)Nc1cc(-n2cc(-c3nc[nH]n3)c(-c3cc(CN4CCCC4)ccc3Cl)n2)c(C)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090227640A1,CC(C)(C)c1ccc(COc2ccccc2/C=C/C(CCCCC#N)CCc2ccc(C(=O)NN)cc2)cc1.O=C(Cl)OC(Cl)(Cl)Cl>>CC(C)(C)c1ccc(COc2ccccc2/C=C/C(CCCCC#N)CCc2ccc(-c3n[nH]c(=O)o3)cc2)cc1,,C1COCCO1,,,,val
US20160257657A1,C[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H](C)N1.Cc1ccccc1Br>>Cc1cccc(N2C(C)CN(C(=O)OC(C)(C)C)CC2C)c1,,C1COCCO1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US05135937,N#Cc1ccc(C(c2ncc[nH]2)C2(O)CCCCCC2)cc1>>N#Cc1ccc(C(=C2CCCCCC2)c2ncc[nH]2)cc1,,ClCCl,,O=S(Cl)Cl,,val
US05206257,N#Cc1nc(-c2c(Cl)cc(C(F)(F)F)cc2Cl)[nH]c1C#N.O>>N#Cc1[nH]c(-c2c(Cl)cc(C(F)(F)F)cc2Cl)nc1C(N)=O,,O,,Cl,[Na+].[OH-],val
US20120245144A1,Cc1nc(-c2cn3c(n2)-c2cc(SC4CCN(C(C)C)CC4)ccc2OCC3)n(C(C)C)n1.O=C(OO)c1cccc(Cl)c1>>Cc1nc(-c2cn3c(n2)-c2cc(S(=O)C4CCN(C(C)C)CC4)ccc2OCC3)n(C(C)C)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090105259A1,CC(C)C[C@@H](CN(CCCCNS(=O)(=O)c1ccc(Cl)cc1Cl)C(=O)OCC1c2ccccc2-c2ccccc21)NC(=O)Nc1ccccc1>>CC(C)C[C@@H](CNCCCCNS(=O)(=O)c1ccc(Cl)cc1Cl)NC(=O)Nc1ccccc1,,CN(C)C=O,,C1CCNCC1,,val
US20020082280A1,CCCc1nc2ccc(C(N)=O)cc2n1Cc1ccccc1Cl>>CCCc1nc2ccc(C#N)cc2n1Cc1ccccc1Cl,Cl[Ti](Cl)(Cl)Cl,C1CCOC1,,CCN(CC)CC,ClCCl,val
US20080227797A1,CS(=O)(=O)Cl.N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3ccc(F)c(F)c3)c2=O)CC1>>CS(=O)(=O)N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3ccc(F)c(F)c3)c2=O)CC1,,c1ccncc1,,Cl,,val
US20130345192A1,NC(=O)c1cnc2[nH]ccc2c1NC1CCCNC1.O=C=NCc1ccccc1>>NC(=O)c1cnc2[nH]ccc2c1NC1CCCN(C(=O)NCc2ccccc2)C1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20050043315A1,CC(C)n1nc(-c2c(-c3ccccc3)nc(N)nc2S(C)=O)ccc1=O.CCN>>CCNc1nc(N)nc(-c2ccccc2)c1-c1ccc(=O)n(C(C)C)n1,,C1CCOC1,,,,val
US20130338140A1,CN1C[C@@H](Oc2ccc(Cl)c(F)c2)[C@H](N)C1.O=C(n1ccnc1)n1ccnc1.c1nc(NC2CCOCC2)nc2c1CCNC2>>CN1CC(NC(=O)N2CCc3cnc(NC4CCOCC4)nc3C2)C(Oc2ccc(Cl)c(F)c2)C1,,ClCCl,,,,val
US20150266838A1,Brc1cc(Br)c2nonc2c1.NCc1ccccc1>>Brc1cc(NCc2ccccc2)c2nonc2c1,,CS(C)=O,O,,,val
US20050148627A1,CCOC(=O)C1=Cc2cc(Cl)cc(C#Cc3ccccc3)c2OC1C(F)(F)F>>CCOC(=O)C1=Cc2cc(Cl)cc(CCc3ccccc3)c2OC1C(F)(F)F,,CCO,,,,val
US20090099207A1,CC(C)(C)c1cccc(C2(N)CC2)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)c1cccc(C2(N=C=O)CC2)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140275523A1,N#Cc1ccc(Cl)cc1F.NO>>N=C(NO)c1ccc(Cl)cc1F,,CO,,CCN(CC)CC,Cl,val
US20020173655A1,O=S(=O)(CCCCn1cnc2c(N(Cc3ccccc3)Cc3ccccc3)nc3ccccc3c21)c1ccccc1>>Nc1nc2ccccc2c2c1ncn2CCCCS(=O)(=O)c1ccccc1,,ClCCl,,O=S(=O)(O)C(F)(F)F,,val
US20110172476A1,CCC=CC(=O)O.CCCCO>>C=CCC.CCC=O.O=C=O,,CCCCO,,,,val
US06693101B2,COc1ccc([C@H](CC(=O)O)N(C)C(=O)CCCCc2nc(N)cc3ccccc23)cn1>>COc1ccc([C@H](CC(=O)O)N(C)C(=O)CCCCc2nc(N)cc3c2CCCC3)cn1,O=[Pt]=O,CC(=O)O,CCO,,,val
US06100257,O=S(Cl)Cl.OCc1ccc(Cl)cc1F>>Fc1cc(Cl)ccc1CCl,,C1CCOC1,c1ccncc1,,,val
US20050197338A1,NC(=O)Nc1cn(-c2ccc(I)cc2)nc1C(N)=O.Sc1ccccn1>>NC(=O)Nc1cn(-c2ccc(Sc3ccccn3)cc2)nc1C(N)=O,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090099224A1,CCC1(OC(=O)OCc2ccccc2)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccccc1c2CC[Si](C)(C)CCCO.O=C(Cl)c1ccco1>>CCC1(OC(=O)OCc2ccccc2)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccccc1c2CC[Si](C)(C)CCCOC(=O)c1ccco1,CN(C)c1ccncc1,ClCCl,,,,val
US20150080369A1,C=Cc1c(F)cc(S(=O)(=O)N(CC(C)C)c2ccc(C)cc2C)cc1F.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(N(CC(C)C)S(=O)(=O)c2cc(F)c(C3CO3)c(F)c2)c(C)c1,,ClCCl,,,,val
US20050037919A1,CC1=Cc2c(ccc(C)c2-c2cc(C)cc(C)c2)C1.[Li]CCCC>>Cc1cc(C)cc(-c2c(C)ccc3[cH-]c(C)cc23)c1.[Li+],,CCCCC,,,,val
US20020019404A1,N#CN.Nc1ccc(Cl)cc1.O=[N+]([O-])O>>N=C(N)Nc1ccc(Cl)cc1.O=[N+]([O-])O,,CCO,,,,val
US03957763,CCC1(C)OC1CCC(C)=CCOc1ccc2c(c1)OCCC2>>CCC1(C)OC1CCC(C)CCOc1ccc2c(c1)OCCC2,O=[Pt],CCOC(C)=O,,[H][H],,val
US20030199440A1,CC(C)(C)OC(=O)CNC(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1.O=C(O)C(F)(F)F>>N=C(N)Nc1ncc(Cl)c2ccc(C(=O)NCC(=O)O)cc12.O=C(O)C(F)(F)F,,Cc1ccccc1,,,,val
US20150119373A1,CC(C)(C)OC(=O)N1CCC(OCCN2CCOCC2)CC1.ClCCl>>C1CC(OCCN2CCOCC2)CCN1.Cl,,C1COCCO1,,,,val
US20060293322A1,CS(=O)(=O)Cl.OCCC1CCc2c(sc3ncnc(Nc4ccc(OCc5ccccn5)c(Cl)c4)c23)C1>>CS(=O)(=O)OCCC1CCc2c(sc3ncnc(Nc4ccc(OCc5ccccn5)c(Cl)c4)c23)C1,,ClCCl,,,,val
US20120142717A1,C=Cc1cc(F)c(Oc2ccc(Cl)c(C(F)(F)F)c2)c(F)c1.OO>>OCCc1cc(F)c(Oc2ccc(Cl)c(C(F)(F)F)c2)c(F)c1,,C1CCOC1,,B1C2CCCC1CCC2,[Na+].[OH-],val
US20160207893A1,COc1ncc2c(n1)C(=O)NCCS2>>COc1ncc2c(n1)CNCCS2,,O,,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20040014766A1,COC(=O)c1nn(C)cc1N.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>COC(=O)c1nn(C)cc1NC(c1ccccc1)(c1ccccc1)c1ccccc1,,CN(C)C=O,,CCN(CC)CC,,val
US20060223826A1,CCOC(=O)c1ccc2c(c1)NC(=O)CC2>>O=C1CCc2ccc(C(=O)O)cc2N1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20120077781A1,CC(C)(C)OC(=O)CCCCCCBr.Cc1cc([N+](=O)[O-])c(N)cc1C1CC1>>Cc1cc([N+](=O)[O-])c(NCCCCCCC(=O)OC(C)(C)C)cc1C1CC1,,CN(C)C=O,,[H][H],[H-].[Na+],val
US20050059650A1,CCOC(=O)Cl.CS(=O)(=O)c1ccc(-n2ncc3c(OC4CCNCC4)ncnc32)cc1>>CCOC(=O)N1CCC(Oc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2)CC1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US06462042B1,CCOC(=O)C(CC(=O)O)C(C)C.NC1CCC(c2ccccc2)CC1>>CCOC(=O)C(CC(=O)NC1CCC(c2ccccc2)CC1)C(C)C,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US05041455,CC(C)Oc1nsnc1-c1cccnc1.CI>>CC(C)Oc1nsnc1-c1ccc[n+](C)c1.[I-],,CC(C)=O,,,,val
US20130190312A1,Cc1cc(Oc2ccc(Oc3ccccc3)cc2)cc(C)c1-c1csc(N)n1.O=C(Cl)c1ccncc1>>Cc1cc(Oc2ccc(Oc3ccccc3)cc2)cc(C)c1-c1csc(NC(=O)c2ccncc2)n1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20070287701A1,CC(C)(C)OC(=O)NC(C)(C)[C@H]1CCN(Cc2ccccc2)C1>>CC(C)(C)OC(=O)NC(C)(C)[C@H]1CCNC1,[Pd],CO,,,,val
US20120115856A1,Cc1nc2cc(-c3nc4ccccc4o3)ccc2n1CC(=O)OC(C)(C)C>>Cc1nc2cc(-c3nc4ccccc4o3)ccc2n1CC(=O)O,,ClC(Cl)Cl,,CO,[Na+].[OH-],val
US08569535B2,CCOC(=O)C1(NC(=O)c2cccc(C)c2OC2CCC2)Cc2ccc(Cl)c(Cl)c2C1>>Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(Cl)c(Cl)c3C2)c1OC1CCC1,,CCO,,[K+].[OH-],,val
US05350872,COc1ccc(C=C2C(=O)OC(C)(C)OC2=O)cc1OC>>COc1ccc(CCC(=O)O)cc1OC,,CCN(CC)CC,,O=CO,,val
US04024149,CCOC(=O)CC(=O)Cl.N=C(c1ccccc1)N(N)c1ccccc1>>CCOC(=O)Cc1nc(-c2ccccc2)nn1-c1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US20140080798A1,Cc1cnc(Nc2ccc(OC3CCN(C(=O)OC(C)(C)C)CC3)cc2)nc1CCc1ccccc1CC(N)=O>>Cc1cnc(Nc2ccc(OC3CCNCC3)cc2)nc1CCc1ccccc1CC(N)=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090054478A1,COC(=O)CC(C)=O.Nc1cc(O)[nH]n1>>Cc1cc(O)nc2[nH]nc(O)c12,,Cl,,O,,val
US04788206,CCCCC/C(=C\C=C\C(=O)O)c1cccc(F)c1.O=[N+]([O-])c1ccc(O)cc1>>CCCCC/C(=C\C=C\C(=O)Oc1ccc([N+](=O)[O-])cc1)c1cccc(F)c1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150152095A1,COc1c(O)nc(N2CCC[C@H]2c2ccc(C)cc2)nc1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1c(OS(=O)(=O)C(F)(F)F)nc(N2CCC[C@H]2c2ccc(C)cc2)nc1OS(=O)(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US04703036,O=C(N[C@H](Cc1ccccc1)C(=O)O)OCc1ccccc1.Oc1cc(Cl)c(Cl)cc1Cl>>O=C(N[C@H](Cc1ccccc1)C(=O)Oc1cc(Cl)c(Cl)cc1Cl)OCc1ccccc1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20070037802A1,COc1ccc([N+](=O)[O-])c(OCCCl)c1.O=S(=O)(CCl)c1cccc2ccccc12>>COc1cc(CS(=O)(=O)c2cccc3ccccc23)c([N+](=O)[O-])c(OCCCl)c1,,C1CCOC1,,Cl,CC(C)(C)[O-].[K+],val
US20140179715A1,N#C[Zn]C#N.N#Cc1cc(C=O)ccc1Oc1ccnc(Cl)c1>>N#Cc1cc(Oc2ccc(C=O)cc2C#N)ccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(=O)N(C)C,,,,val
US20140088100A1,COc1cc(OC)c(Cl)c(-c2cc3cnc(Nc4ccccc4[N+](=O)[O-])c(C)c3n(C)c2=O)c1Cl>>COc1cc(OC)c(Cl)c(-c2cc3cnc(Nc4ccccc4N)c(C)c3n(C)c2=O)c1Cl,,CCOC(C)=O,,,,val
US05849764,COc1ccc(-c2[nH]c3ccccc3c2CCNC(=O)CCc2ccc3[nH]ccc3c2)cc1OC>>COc1ccc(-c2[nH]c3ccccc3c2CCNCCCc2ccc3[nH]ccc3c2)cc1OC,,O,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140296313A1,CC(C)(C)OC(=O)NC1(Cc2nc(-c3ccc(OC(F)(F)F)cc3)c[nH]2)CCOCC1>>NC1(Cc2nc(-c3ccc(OC(F)(F)F)cc3)c[nH]2)CCOCC1,,C1COCCO1,,Cl,,val
US20110021522A1,CCOc1ccc(B(O)O)cc1C.Nc1cccc(Br)c1>>CCOc1ccc(-c2cccc(N)c2)cc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20090023703A1,COc1ccc(C(=O)CN2C(=O)c3ccccc3C2=O)cc1.OCCO>>COc1ccc(C2(CN3C(=O)c4ccccc4C3=O)OCCO2)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070225271A1,CC(C)(C)OC(=O)N1CCC(Nc2ncc(O)cn2)CC1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCC(Nc2ncc(OS(C)(=O)=O)cn2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150038512A1,CC(C)CN(CCCOc1cc(CO)cc(CO)c1)C(=O)OC(C)(C)C>>CC(C)CN(CCCOc1cc(C=O)cc(C=O)c1)C(=O)OC(C)(C)C,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US04281000,Cc1ccnc(C(=O)C=CN(C)C)c1.N#Cc1c[nH]nc1N>>Cc1ccnc(-c2ccnc3c(C#N)cnn23)c1,,CC(=O)O,,,,val
US20040122057A1,CCOC(C(=O)NCc1ccc(C#N)cc1)c1c(F)cc(-c2ccccc2O)cc1F.CN(C)CCCl>>CCOC(C(=O)NCc1ccc(C#N)cc1)c1c(F)cc(-c2ccccc2OCCN(C)C)cc1F,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20130331372A1,COB(OC)OC.COC(=O)c1ccc(-c2ccc(OC)c(I)c2)c(C)c1>>COC(=O)c1ccc(-c2ccc(OC)c(B(O)O)c2)c(C)c1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20100137302A1,COc1ccc2c(c1)OCCN2c1nc2c(s1)C(=O)NC(C)(C)C2.O=C1CCC(=O)N1Br>>COc1cc2c(cc1Br)N(c1nc3c(s1)C(=O)NC(C)(C)C3)CCO2,,C1CCOC1,CC#N,,,val
US05073556,CCOC(=O)c1cc(F)c(F)c(OC(F)F)c1F>>O=C(O)c1cc(F)c(F)c(OC(F)F)c1F,,CCO,,Cl,[Na+].[OH-],val
US20130190248A1,CC(C)(C)OC(=O)N[C@@H](CN)C(=O)O.NCCc1ccncc1.O=C(O)C(F)(F)F>>NCCc1ccncc1.NC[C@H](N)C(=O)O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05278264,CCC1Cc2c(C)cccc2C1O>>CCC1Cc2c(C)cccc2C1=O,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04126635,Nc1c(CC(=O)O)cccc1C(=O)c1ccccc1.[Na+].[OH-]>>Nc1c(CC(=O)[O-])cccc1C(=O)c1ccccc1.O.[Na+],,C1CCOC1,,[Na],,val
US20080300242A1,CCOc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)ccc1N.CCOc1ccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)cc1C(=O)Nc1c(F)cccc1F>>CCOc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)ccc1Nc1nccc(-c2c(-c3ccc(OCC)c(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1,,CC(C)O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20130072677A1,C1CNCCOC1.CCOC(=O)c1ccc(C#Cc2ccc(C=O)cc2)cc1>>CCOC(=O)c1ccc(C#Cc2ccc(CN3CCCOCC3)cc2)cc1,,CC(=O)O,ClC(Cl)Cl,Cl,O=C([O-])O.[Na+],val
US20080318944A1,Cc1nc(C(=O)N2CCCCC2Cc2cc3ncccc3o2)c(-c2ccc(F)cc2)s1.ClCl>>Cc1nc(C(=O)N2CCCCC2Cc2oc3cccnc3c2Cl)c(-c2ccc(F)cc2)s1,,ClCCl,,,,val
US20120009151A1,CCOc1nc(Cl)nc(Cl)n1.Nc1ccc2[nH]c(=O)[nH]c2c1>>CCOc1nc(Cl)nc(Nc2ccc3[nH]c(=O)[nH]c3c2)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US05288743,CC(=O)Nc1ccc(OCc2ccccn2)cc1>>Nc1ccc(OCc2ccccn2)cc1,,CCO,,[K+].[OH-],,val
US20040162276A1,CCOC(=O)CN.O=CC1=C(Cl)C=CC(c2ccccc2)(c2ccccc2)C1>>CCOC(=O)c1[nH]cc2c1C=CC(c1ccccc1)(c1ccccc1)C2,,CN(C)C=O,,Cl,,val
US20020049316A1,CC(C)CN.O=C(Cl)C1CC1>>CC(C)C(=O)NCC1CC1,,ClCCl,,CCN(CC)CC,,val
US20150119385A1,CCOC(=O)CSCCNC(=O)OC(C)(C)C>>CCOC(=O)CSCCN,,C1COCCO1,,Cl,,val
US20060046999A1,C#CC(=O)OC.N=C(CC(=O)c1ccc(F)cc1)Nc1ccc(F)cc1>>Nc1c(C(=O)c2ccc(F)cc2)ccc(=O)n1-c1ccc(F)cc1,,CO,,,,val
US20100120761A1,Brc1cccc(NC2CCOCC2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC1(C)OB(c2cccc(NC3CCOCC3)c2)OC1(C)C,,CS(C)=O,,CC(=O)[O-].[K+],,val
US06642264B1,CN(C(=O)c1cn2c(nc3ccccc32)s1)C1CCCCC1.O=[N+]([O-])O>>CN(C(=O)c1cn2c(nc3ccc([N+](=O)[O-])cc32)s1)C1CCCCC1,,O=S(=O)(O)O,,N,,val
US20120225854A1,COC(=O)CNC(=O)[C@H](CC1CCOCC1)NC(=O)OC(C)(C)C>>O=C1CNC(=O)[C@H](CC2CCOCC2)N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100041638A1,CCOC(=O)c1csc(C(C)(C)C)n1>>CC(C)(C)c1nc(C(=O)O)cs1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20040204402A1,C1=C(c2c[nH]c3ccccc23)CCNC1.O=c1n(CCCCl)nc2ccccn12>>O=c1n(CCCN2CC=C(c3c[nH]c4ccccc34)CC2)nc2ccccn12,,CC(C)=O,O,[I-].[K+],,val
US20120115882A1,C=C1CCN(C(=O)OC(C)(C)C)[C@H](C(=O)OCc2ccccc2)C1.C=[N+]=[N-]>>CC(C)(C)OC(=O)N1CCC2(CC2)C[C@H]1C(=O)OCc1ccccc1,,C1CCOC1,CCOCC,,,val
US06429229B1,NCCC[C@H](N)C(=O)O.O=C(O)CCC(=O)C(=O)O>>CCC(=O)C(=O)O.NCCC[C@H](N)C(=O)O,,CC(C)=O,,,,val
US05401825,C=Cc1ccc(N)cc1.Cc1cccc(N=C=O)c1>>C=Cc1ccccc1.Cc1cccc(NC(N)=O)c1,,ClC(Cl)Cl,,,,val
US08110687B2,CC(=O)NC(C)(C)c1cc(N)cc(C(F)(F)F)c1>>CC(C)(N)c1cc(N)cc(C(F)(F)F)c1,,Cl,O,,,val
US20040248918A1,Cc1ccc(N)cc1[N+](=O)[O-].N#CN.O=[N+]([O-])O>>Cc1ccc(NC(=N)N)cc1[N+](=O)[O-].O=[N+]([O-])O,,CCO,O,,,val
US20090203676A1,CC(C)(C)OC(=O)N1CCC(CCN2CCN(c3ccc(S(C)(=O)=O)cc3)CC2)CC1>>CS(=O)(=O)c1ccc(N2CCN(CCC3CCNCC3)CC2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050171350A1,CC(C)OC=O.CCOc1cc(OCC)nc(OCC)n1>>CCOc1nc(OCC)c(C=O)c(OCC)n1,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US20130274269A1,C[C@H](CO)NC(=O)OC(C)(C)C.O=[N+]([O-])c1ccccc1S(=O)(=O)NCCc1ccccc1Cl>>C[C@@H](N)CN(CCc1ccccc1Cl)S(=O)(=O)c1ccccc1[N+](=O)[O-],,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060094843A1,CCCCCCC1(C(=O)OCC)CCCC1O.O=C(Cl)c1ccccc1>>CCCCCCC1(C(=O)OCC)CCCC1OC(=O)c1ccccc1,,ClCCl,,c1ccncc1,,val
US20150151009A1,CC1(C)Sc2cc3c(c(CO)c2S1)SC(C)(C)S3.C[Si](C)(C)Cl.NC(CO)(CO)CO>>CC1(C)Sc2c(CO)c3c(c([Si](C)(C)C)c2S1)SC(C)(C)S3.NC(CO)(CO)CO,,CCOCC,,CCCCCC,[Li]CCCC,val
US20150057271A1,COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(c2)OC(C)C(=O)N3)cc1>>COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(c2)OC(C)CN3)cc1,,C1CCOC1,CO,B,CSC,val
US20040180940A1,CCOC(=O)CC(=O)Nc1cc(Br)c(Oc2cc(C=O)c(O)c(C(C)C)c2)c(Br)c1C>>Cc1c(NC(=O)CC(=O)O)cc(Br)c(Oc2cc(C=O)c(O)c(C(C)C)c2)c1Br,,C1CCOC1,,Cl,[Li+].[OH-],val
US20120101124A1,COC(=O)CCc1ccc(-c2noc(-c3cnc(OC(C)C)c(Cl)c3)n2)c2ccn(C)c12>>CC(C)Oc1ncc(-c2nc(-c3ccc(CCC(=O)O)c4c3ccn4C)no2)cc1Cl,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20090286835A1,C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]2(C)C=CC(=O)C=C12>>C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]2(C)CCC(=O)C=C12,,CCO,CCOC(C)=O,[H][H],,val
US20030078277A1,Cc1cc(C)c(-c2ccncc2NC(=O)OC(C)(C)C)c(C)c1>>Cc1cc(C)c(-c2ccncc2N)c(C)c1,,CCOC(C)=O,,Cl,[Na+].[OH-],val
US20100197651A1,CN(C)C=CC(=O)c1nn(-c2cccc(Cl)c2)ccc1=O.NNc1ccccc1>>O=c1ccn(-c2cccc(Cl)c2)nc1-c1ccnn1-c1ccccc1,,CO,,,,val
US20150336949A1,CC(C)(C)OC(=O)N1CCC(Cc2cccc(-c3cnc4[nH]cc(-c5cnn(CCc6ccccc6)c5)c4c3)c2)CC1>>c1ccc(CCn2cc(-c3c[nH]c4ncc(-c5cccc(CC6CCNCC6)c5)cc34)cn2)cc1,,CO,Cl,,,val
US20050107345A1,CCCCCCCCCCCCC(CCP(=O)(OCC)OCC)C(=O)OCC>>CCCCCCCCCCCCC(CCP(=O)(OCC)OCC)C(=O)O,,CCOC(C)=O,CO,[Na+].[OH-],,val
US05182272,O=C(Cc1cccs1)NCCC(=O)NNC(=O)N1Cc2ccccc2Sc2ccc(Cl)cc21.OO>>O=C(Cc1cccs1)NCCC(=O)NNC(=O)N1Cc2ccccc2S(=O)c2ccc(Cl)cc21,,CC(=O)O,,,,val
US20070219186A1,CCOC(=O)c1cn[nH]c1N.CN(C)C=CC(=O)c1cccc([N+](=O)[O-])c1>>CCOC(=O)c1cnn2c(-c3cccc([N+](=O)[O-])c3)ccnc12,,CC(=O)O,,,,val
US05859011,CN(C)CCCN1CCN(C(=O)OCc2ccccc2)CC1>>CN(C)CCCN1CCNCC1,[Pd],CO,,,,val
US20150361100A1,CC(c1cc2ccccn2c1-c1ccc(CN(CCO[Si](C)(C)C(C)(C)C)CCO[Si](C)(C)C(C)(C)C)cn1)n1nc(I)c2c(N)ncnc21.OB(O)c1cc(O)cc(F)c1>>CC(c1cc2ccccn2c1-c1ccc(CN(CCO)CCO)cn1)n1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20140171431A1,CCNCC.O=Cc1nnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1>>CCN(CC)Cc1nnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1,,ClCCl,,,,val
US06518265B1,N#CCN1CCC2(CC1)OCCO2>>NCCN1CCC2(CC1)OCCO2,[Ni],,,N,,val
US06228859B1,COc1ccc(Cn2c(N)c(NC(=O)C(C)(C)OCc3ccccc3)c(=O)[nH]c2=S)cc1OCc1ccccc1>>COc1ccc(Cn2c(=S)[nH]c(=O)c3[nH]c(C(C)(C)OCc4ccccc4)nc32)cc1OCc1ccccc1,,CC(C)O,ClCCl,CC(C)(C)[O-].[K+],,val
US20100240656A1,CCC(=O)Cl.Cc1c(N)c(C(N)=O)nn1Cc1cc2c(cc1Br)OCO2>>CCC(=O)Nc1c(C(N)=O)nn(Cc2cc3c(cc2Br)OCO3)c1C,,ClCCl,,CCN(CC)CC,O,val
US05665328,CCCCCCCCCCCCCCCCCCCCCCCCCCO.O=S(=O)(Cl)c1ccc(Cl)cc1>>CCCCCCCCCCCCCCCCCCCCCCCCCCOS(=O)(=O)c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20080262042A1,CN(Cc1cc(Br)n(S(=O)(=O)c2cccnc2)c1)C(=O)OC(C)(C)C.OB(O)c1cccnc1Cl>>CN(Cc1cc(-c2cccnc2Cl)n(S(=O)(=O)c2cccnc2)c1)C(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20160176916A1,CC(C)(C)OC(=O)NCCCCCCN.O=C1CCC(N2C(=O)c3ccc(C(=O)O)cc3C2=O)C(=O)N1>>CC(C)(C)OC(=O)NCCCCCCNC(=O)c1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O,,CCOC(C)=O,CN(C)C=O,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20120202777A1,CC(CCc1ccc(-c2ccccc2)cc1F)(C(=O)NOC1CCCCO1)S(C)(=O)=O>>CC(CCc1ccc(-c2ccccc2)cc1F)(C(=O)NO)S(C)(=O)=O,,C1COCCO1,ClCCl,Cl,,val
US20150166480A1,CC(C)(C)OC(=O)N1CCC(COc2ccc(Br)c(F)c2)CC1.Cl>>Cl.Fc1cc(OCC2CCNCC2)ccc1Br,,ClCCl,,C1COCCO1,,val
US20030078282A1,CCCCCCN1CCC(C)(c2cccc(N)c2)CC1.CCS(=O)(=O)Cl.c1ccncc1>>CCCCCCN1CCC(C)(c2cccc(NS(=O)(=O)CC)c2)CC1.N,,ClCCl,,,,val
US20120220588A1,CNS(=O)(=O)c1ccc(OCC(F)(F)F)c(N)c1.COc1cc2c(Cl)ncnc2cc1OCc1ccccc1>>CNS(=O)(=O)c1ccc(OCC(F)(F)F)c(Nc2ncnc3cc(OCc4ccccc4)c(OC)cc23)c1,,CC(C)O,,,,val
US20060128722A1,COC(=O)c1ccc2c(Sc3ccccc3[N+](=O)[O-])cn(Cc3cc(F)cc(F)c3)c2c1>>O=C(O)c1ccc2c(Sc3ccccc3[N+](=O)[O-])cn(Cc3cc(F)cc(F)c3)c2c1,,C1COCCO1,O,Cl,[Li]O,val
US06492403B1,COC(=S)c1cc(C(N)=S)c(C)s1.O=C(CBr)c1cccc(Br)c1>>COC(=S)c1cc(-c2nc(-c3cccc(Br)c3)cs2)c(C)s1,,CC(C)=O,,,,val
US20060293311A1,COc1ccc(N)nc1NC(=O)C(C)(C)C.Fc1cnc(Cl)nc1Cl>>COc1ccc(Nc2nc(Cl)ncc2F)nc1NC(=O)C(C)(C)C,,CO,,O,,val
US20140179676A1,COC(=O)c1cc(OC)c(Cl)cc1Br>>COc1cc(CO)c(Br)cc1Cl,,C1CCOC1,,[BH4-].[Li+],,val
US20110082294A1,C=CC[C@H]1COC[C@@H](C=O)N1C(=O)OC(C)(C)C.COC(=O)[C@H](C)N.O=C(Cl)OCc1ccccc1>>C=CC[C@H]1COC[C@@H](CN(C(=O)OCc2ccccc2)[C@@H](C)C(=O)OC)N1C(=O)OC(C)(C)C,,ClCCl,O,Cl,O=C([O-])O.[Na+],val
US05308837,O=C1NC(=O)c2ccccc21.OC/C=C\COC1CCCCO1>>O=C1c2ccccc2C(=O)N1C/C=C\COC1CCCCO1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040019098A1,COc1ccc(CN(C)c2ccc3c(c2)C(=C2C(=O)N(CO)c4ccccc42)OC3)c(OC)c1>>CNc1ccc2c(c1)C(=C1C(=O)N(CO)c3ccccc31)OC2,,C1CCOC1,Cl,,,val
US20140288260A1,Brc1cc2ccccc2c2ccccc12.CCO[Ge](OCC)(OCC)OCC>>CCO[Ge](OCC)(OCC)c1cc2ccccc2c2ccccc12,,C1CCOC1,,[Mg],,val
US05506261,O=Cc1cccnc1.[Li]c1cccs1>>OC(c1cccnc1)c1cccs1,,C1CCOC1,,CO,ClC(Cl)Cl,val
US20130231333A1,BrCc1ccc(Br)cc1CBr.CCOC(=O)CC(=O)OCC>>CCOC(=O)C1(C(=O)OCC)Cc2ccc(Br)cc2C1,,CCOCC,,CCO,[H-].[Na+],val
US20040048918A1,C=C1C(=O)[C@]23[C@H](O)[C@H]1CC[C@H]2[C@@]12C(OC)O[C@H]3C[C@@H]1C(C)(C)CC[C@@H]2O>>C=C1C(=O)[C@@]23[C@H](O)C[C@@H]4C(C)(C)CC[C@H](O)[C@@]4(CO)[C@@H]2CC[C@@H]1[C@H]3O,,CCCCCC,CCOC(C)=O,,,val
US04888332,O=C(Cl)c1ccccc1.O=C(O)/C(=N\O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>O=C(O)/C(=N\OC(=O)c1ccccc1)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1,,ClCCl,,CCN(CC)CC,,val
US20150191476A1,Cc1ccnc(CO)n1.O=S(Cl)Cl>>Cc1ccnc(CCl)n1,,ClCCl,,,,val
US20100105653A1,CC(C)=O.CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1>>CC(C)N1CCN(c2ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc2)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20050059702A1,COC(=O)c1ccc(CBr)c(C(=O)OC)c1.Cc1cccnc1C1CCCC(c2ncccc2C)N1>>COC(=O)c1ccc(CN2C(c3ncccc3C)CCCC2c2ncccc2C)c(C(=O)OC)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20050032838A1,CCOC(=O)c1cc(F)cnc1Oc1cccc(SCC)c1>>CCSc1cccc(Oc2ncc(F)cc2C(=O)O)c1,,C1CCOC1,O,[Li+].[OH-],,val
US05399703,COc1cccc(Sc2ccccc2N)c1-c1nnn[nH]1>>Nc1ccccc1Sc1cccc(O)c1-c1nnn[nH]1,,CN(C)C=O,,Cl,,val
US20070021473A1,CCOC(=O)c1ccc(-c2ccc(OCCCI)c(-c3ccc4c(c3)C(C)(C)CCC4(C)C)c2)cc1.CN>>CCOC(=O)c1ccc(-c2ccc(OCCCNC)c(-c3ccc4c(c3)C(C)(C)CCC4(C)C)c2)cc1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US04070178,FC(F)(F)c1ccc(Oc2ccc(OCc3ccccc3)cc2)c(Cl)c1>>Oc1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1,[Pd],CCOC(C)=O,,CO,[H][H],val
US20040162321A1,CC(C)(CC1(C(F)(F)F)CO1)c1cccc(C2(C)OCCO2)c1.Oc1ccnc2ccccc12>>CC(C)(CC(O)(Cn1ccc(=O)c2ccccc21)C(F)(F)F)c1cccc(C2(C)OCCO2)c1,,CCO,,C,C[O-].[Na+],val
US20130158075A1,COC(=O)CCCC(=O)Cl.NC(=NO)c1ccc([N+](=O)[O-])cc1>>COC(=O)CCCc1nc(-c2ccc([N+](=O)[O-])cc2)no1,,Cc1ccccc1,,,,val
US20110053940A1,CCOC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1c1ccncc1.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1c1cc[n+]([O-])cc1,,ClCCl,,,,val
US20070148592A1,O=C(O)CCc1ccccc1.O=C1OCCC1Br>>O=C(CCc1ccccc1)OC1CCOC1=O,,CCOC(C)=O,O,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US05405861,CC(=O)OCC(N)=S.O=C1CCCC1Cl>>CC(=O)OCc1nc2c(s1)CCC2,,CN(C)C=O,,,,val
US20150152096A1,C[C@@]1(C(=O)OCc2ccccc2)COCC(=O)N1Cc1ccccc1>>C[C@@]1(C(=O)OCc2ccccc2)COCCN1Cc1ccccc1,,C1CCOC1,,B,,val
US20040235901A1,OCc1cccnc1-c1cccnc1>>Cc1cccnc1-c1cccnc1,[Pd],CO,,C1COCCO1,Cl,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCC3(C#N)CC3)cc1CC2CC>>CCC1Cc2cc(OCC3(C#N)CC3)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21,,CO,O,[Li]O,,val
US20060014777A1,CC(C)(C)OC(=O)N1C[C@H]2NC(=O)c3c(cccc3C(F)(F)F)[C@H]2C1.CI>>CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CN(C(=O)OC(C)(C)C)C[C@H]21,,C1CCOC1,,[H-].[Na+],,val
US05886014,CC1=CC(=O)C(C)=C(C)C1=O.NO>>CC1=CC(=NO)C(C)=C(C)C1=O,,CO,O,Cl,,val
US20060183921A1,CCOC(=O)c1c(-c2ccccc2C)csc1N.O=C1OC(=O)c2ccccc21>>CCOC(=O)c1c(-c2ccccc2C)csc1N1C(=O)c2ccccc2C1=O,,CC(=O)O,,,,val
US20030203896A1,Cc1nc(NC[C@H](NS(=O)(=O)c2cccc3ccccc23)C(=O)OC(C)(C)C)c2ccn(CCCC(=O)NC3=NCCCN3)c2n1>>Cc1nc(NC[C@H](NS(=O)(=O)c2cccc3ccccc23)C(=O)O)c2ccn(CCCC(=O)NC3=NCCCN3)c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090275606A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=c1c(F)c2c([nH]c(=O)n2-c2ccc(Br)cc2F)c2n1CCC2>>CC(C)(C)OC(=O)n1c(=O)n(-c2ccc(Br)cc2F)c2c(F)c(=O)n3c(c21)CCC3,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20060040957A1,CC#CCBr.Cc1c(=O)[nH]c(=O)n2cc(C(=O)NCc3ccc(F)cc3)sc12>>CC#CCn1c(=O)c(C)c2sc(C(=O)NCc3ccc(F)cc3)cn2c1=O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04069319,CO.ClCc1ccc(Cl)cc1Cl.N#CN=C([S-])[S-]>>Oc1nsc(SCc2ccc(Cl)cc2Cl)n1,,CO,,O,,val
US20090233965A1,CI.CN1CCC(OC(=O)C(C)(c2ccc(Br)cc2)C2CCCC2)CC1>>CC(C(=O)OC1CC[N+](C)(C)CC1)(c1ccc(Br)cc1)C1CCCC1.[I-],,CC#N,,,,val
US20090239854A1,C=Cc1ccc(C(F)(F)F)nc1.CN1Cc2c([nH]c3ccc(Cl)cc23)C(F)C1>>CN1Cc2c(n(CCc3ccc(C(F)(F)F)nc3)c3ccc(Cl)cc23)C(F)C1,,CN1CCCC1=O,,[K+].[OH-],,val
US20160000760A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Nc1cc(Cl)c(Br)c(C(F)(F)F)c1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(-c3c(Cl)cc(N)cc3C(F)(F)F)cc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20090131256A1,Cc1cc(C)cc(CC(NS(=O)C(C)(C)C)c2cnn(C)c2)c1>>Cc1cc(C)cc(CC(N)c2cnn(C)c2)c1,,C1COCCO1,CO,Cl,,val
US04312876,CCOC(=O)N1CC[C@@H](O)[C@H](c2ccccc2)C1.Cc1ccc(O)cc1>>CCOC(=O)N1CC[C@H](Oc2ccc(C)cc2)[C@H](c2ccccc2)C1,,c1ccccc1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150183791A1,CC(C)(C)OC(=O)n1cc(B(O)O)cn1.Clc1ccc2nccn2n1>>c1cn2nc(-c3cn[nH]c3)ccc2n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,O,CC#N,O=C([O-])[O-].[Na+].[Na+],val
US20080280869A1,COC(=O)c1ccc(Cn2nc(-c3ccc(C(C)C)cc3)oc2=O)cc1>>CC(C)c1ccc(-c2nn(Cc3ccc(C(=O)O)cc3)c(=O)o2)cc1,,O,c1ccncc1,[I-].[Li+],,val
US05576427,BrBr.Cn1cnc2c(N)ncnc21>>Cn1c(Br)nc2c(N)ncnc21,,O,,CC(=O)O,CC(=O)[O-].[Na+],val
US08030354B2,C=CC(C)(C)C(O)c1cc(C(=O)OC)ccc1-c1cc(OC)ccc1F>>CCC(C)(C)C(O)c1cc(C(=O)OC)ccc1-c1cc(OC)ccc1F,[Pd],CO,,,,val
US20060241115A1,COc1cc2[nH]ccc(=O)c2cc1OC.II>>COc1cc2[nH]cc(I)c(=O)c2cc1OC,,[Na+],[OH-],CC(=O)O,,val
US20090318465A1,CN(CCO)C(=O)OC(C)(C)C.COC(=O)C(Cc1ccc(O)cc1)(OC)C(=O)OC>>COC(=O)C(Cc1ccc(OCCN(C)C(=O)OC(C)(C)C)cc1)(OC)C(=O)OC,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160075713A1,CC(C)(C)OC(=O)NC1CCN(CC(F)(F)c2ccc(C(F)F)cc2)CC1>>NC1CCN(CC(F)(F)c2ccc(C(F)F)cc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160176882A1,Cc1ccc(S(=O)(=O)NN)cc1.Cc1nc(C2CC2)nc(Cl)c1Br>>Cc1ccc(S(=O)(=O)NNc2nc(C3CC3)nc(C)c2Br)cc1,,ClC(Cl)Cl,,,,val
US20140057914A1,CCOC(=O)c1nc(Cc2cccc(Br)c2)c(C)o1>>Cc1oc(C(=O)O)nc1Cc1cccc(Br)c1,,CCO,,O,[Na+].[OH-],val
US20080214558A1,CN1CCN(c2ccc(Nc3nccc(Nc4cccc(CC#N)c4)n3)cc2C(F)(F)F)CC1.O=S(=O)(O)O>>CN1CCN(c2ccc(Nc3nccc(Nc4cccc(CC#N)c4)n3)cc2C(F)(F)F)CC1.O=S(=O)(O)O,,CC(C)O,,,,val
US20150133446A1,COC(=O)c1cc2c(C(F)(F)F)cc(C)nc2o1>>Cc1cc(C(F)(F)F)c2cc(C(=O)O)oc2n1,,[Na+],[OH-],Cl,,val
US20100056563A1,COC(=O)c1ccc(OC)nc1Cl.NCc1ccc(C(F)(F)F)cc1>>COC(=O)c1ccc(OC)nc1NCc1ccc(C(F)(F)F)cc1,,COCCOC,,,,val
US04880808,NC(=O)C1CN(Cc2ccccc2)CCN1CCCC=C(c1ccc(F)cc1)c1ccc(F)cc1>>NC(=O)C1CNCCN1CCCCC(c1ccc(F)cc1)c1ccc(F)cc1,[Pd],CO,,[H][H],,val
US05958918,BrC(Br)(Br)Br.OCC1(c2ccccc2)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>BrCCc1ccccc1C1CC1,,C1CCOC1,CCOCC,,,val
US20080125468A1,COC(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)nc1>>OCc1ccc(-c2ccc(C(F)(F)F)cc2)nc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06265575B1,Brc1ccc(OCCN2CCCC2)nc1.OB(O)c1cc2ccccc2s1>>c1ccc2sc(-c3ccc(OCCN4CCCC4)nc3)cc2c1,,ClC(Cl)Cl,,CO,,val
US20150031685A1,O=C(N[C@H](C(=O)O)c1ccccc1)OCc1ccccc1.O[C@H]1CCNC1>>O=C(N[C@H](C(=O)N1CC[C@H](O)C1)c1ccccc1)OCc1ccccc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20060069132A1,CCn1nc(C(C)(C)C)cc1C(=O)Cl.CN1Cc2c(N)cccc2C1=O>>CCn1nc(C(C)(C)C)cc1C(=O)Nc1cccc2c1CN(C)C2=O,,ClCCl,O,CCN(CC)CC,CCOC(C)=O,val
US20160200674A1,Brc1ccccc1-c1nnn(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1.CC1CC(C)CN(c2ccc(B3OCC(C)(C)CO3)cc2N)C1>>CC1CC(C)CN(c2ccc(-c3ccccc3-c3nnn(C(c4ccccc4)(c4ccccc4)c4ccccc4)n3)cc2N)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20150210690A1,CCO.N[C@H](C[C@@H](Cc1ccc(-c2cc(Cl)ccc2F)cc1)NC(=O)c1cnn[nH]1)C(=O)O>>CCOC(=O)[C@H](N)C[C@@H](Cc1ccc(-c2cc(Cl)ccc2F)cc1)NC(=O)c1cnn[nH]1,,CCO,,C1COCCO1,Cl,val
US20130095193A1,CC(C)(C#N)c1cc(B2OC(C)(C)C(C)(C)O2)ccn1.CN(Cc1ccc(-c2nnc(-c3nc(Br)cnc3N)o2)cc1)C(=O)OC(C)(C)C>>CN(Cc1ccc(-c2nnc(-c3nc(-c4ccnc(C(C)(C)C#N)c4)cnc3N)o2)cc1)C(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20080064715A1,Cc1cc(N)ncc1[N+](=O)[O-].Cl[Cu]Cl>>Cc1cc(Cl)ncc1[N+](=O)[O-],Cl[Cu]Cl,CN(C)C=O,,Cl,,val
US20150252032A1,Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@H]2c2nc(-c3cccnc3O)no2)c1.O=C(O)C(F)(F)S(=O)(=O)F>>Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@H]2c2nc(-c3cccnc3OC(F)F)no2)c1,,CC#N,O,[H-].[Na+],,val
US20070037820A1,COC(=O)c1cc(-c2cccc(I)c2)on1>>OCc1cc(-c2cccc(I)c2)on1,,C1CCOC1,Cc1ccccc1,CC(C)C[AlH]CC(C)C,,val
US20140024650A1,CC(C)(C)OC(=O)N[C@H]1CCC(F)(F)C[C@@H]1CO.N#Cc1cnc(-c2ccc(O)cc2)nc1>>CC(C)(C)OC(=O)N[C@H]1CCC(F)(F)C[C@@H]1COc1ccc(-c2ncc(C#N)cn2)cc1,,Cc1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20020151723A1,CCCNc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2C#N)cc1.C[Sn](C)(C)N=[N+]=[N-]>>CCCNc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,Cc1ccccc1,,,,val
US05237064,CC(=O)OC1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]32)C1>>CC(=O)OC1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CCC(O)[C@@]4(C)CC[C@@H]32)C1,,CCO,O,[BH4-].[Na+],,val
US20070037794A1,O=C(c1cccc(Cl)n1)c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1.O=CO>>O=C(c1cccc(O)n1)c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1,,CCOC(C)=O,,O,O=C([O-])O.[Na+],val
US05539112,CC(C)(C)[Si](C)(C)Cl.CCOC(=O)c1c(NC(=O)C(C)(C)C)c(F)c(CO)c(F)c1OC1CCCCO1>>CCOC(=O)c1c(NC(=O)C(C)(C)C)c(F)c(CO[Si](C)(C)C(C)(C)C)c(F)c1OC1CCCCO1,,ClCCl,,O,c1c[nH]cn1,val
US20140275087A1,CCCCNC(=O)O[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1c1ccc(F)cc1>>CCCCNC(=O)O[C@@H]1CNC[C@H]1c1ccc(F)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110294781A1,Cc1cccc(C=O)c1.NNc1cc(N2CCOCC2)n2nc(-c3cncnc3)cc2n1>>Cc1cccc(C=NNc2cc(N3CCOCC3)n3nc(-c4cncnc4)cc3n2)c1,,CCO,,CC(=O)O,,val
US20080081812A1,CCOC(=O)c1nn(-c2ccc(Cl)cc2Cl)c(-c2ccc(Cl)cc2)c1Cl.NN>>NNC(=O)c1nn(-c2ccc(Cl)cc2Cl)c(-c2ccc(Cl)cc2)c1Cl,,CCO,,,,val
US05356904,NCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1.O=CO>>O=CNCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1,,O=CO,,CC(=O)OC(C)=O,,val
US20070254869A1,CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCCN(C(=O)OC(C)C)c2ccc(N=C(c3ccccc3)c3ccccc3)cc21>>CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCCN(C(=O)OC(C)C)c2ccc(N)cc21,,C1CCOC1,CCOC(C)=O,Cl,,val
US04550203,CC(=O)NC#N.ClCc1ccccc1>>CC(=O)N(C#N)Cc1ccccc1,,CN(C)C=O,,[Na],,val
US20120059028A1,CCC(C)I.COC(=O)Cc1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCCC3>>CCC(C)C(C(=O)OC)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCCC3,,CN(C)C=O,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20050182040A1,CC(C)(C)OC(=O)NC1CCC(Nc2ccc(C(N)=O)cc2)CC1.O=C(O)C(F)(F)F>>NC(=O)c1ccc(NC2CCC(N)CC2)cc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20060116396A1,C=CCc1cc(F)cc(C(C)(C)CC(O)(C(=O)OCC)C(F)(F)F)c1O.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>CCOC(=O)C(O)(CC(C)(C)c1cc(F)cc(CC(O)CO)c1O)C(F)(F)F,O=[Os](=O)(=O)=O,O,,CC(C)=O,,val
US20090275573A1,CC(C)(C)OC(=O)N1CC(F)(F)C[C@H]1CNc1cccc(Cl)c1>>FC1(F)CN[C@H](CNc2cccc(Cl)c2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060264644A1,CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1.Cl>>CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1.Cl,,CO,,,,val
US20140088124A1,CCOC(=O)[C@@H]1CC[C@@H](OC2CCNCC2)CC1.Fc1ccc(-c2nc3cc(C(F)(F)F)ccc3[nH]2)cn1>>CCOC(=O)[C@@H]1CC[C@@H](OC2CCN(c3ccc(-c4nc5cc(C(F)(F)F)ccc5[nH]4)cn3)CC2)CC1,,CN1CCCC1=O,,O,O=C([O-])O.[Na+],val
US20130164218A1,CC1(C)C=Cc2cc(C=O)cc(O)c2O1.COCCl>>COCOc1cc(C=O)cc2c1OC(C)(C)C=C2,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040110763A1,CC(C)n1nc(-c2c(-c3ccccc3)nn3ccc(O)cc23)ccc1=O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)n1nc(-c2c(-c3ccccc3)nn3ccc(OS(=O)(=O)C(F)(F)F)cc23)ccc1=O,,ClCCl,,Cc1cccc(C)n1,,val
US20110274638A1,CC(C)(C)OC(=O)N1CC(O)(c2ccccc2)C1>>CC(C)(C)OC(=O)N1CC(O)(C2CCCCC2)C1,[Rh],CO,,CC(=O)O,[H][H],val
US20020045613A1,Cl.Cl.N=C(N)c1cccc(C2=CCNCC2)c1>>Cl.Cl.N=C(N)c1cccc(C2CCNCC2)c1,[Pd],CO,,,,val
US20100174065A1,CC(C)(C)OC(=O)CCBr.CC(C)Oc1ccc(-c2nc(-c3cccc4c3CCNCC4)no2)cc1Cl>>CC(C)Oc1ccc(-c2nc(-c3cccc4c3CCN(CCC(=O)OC(C)(C)C)CC4)no2)cc1Cl,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20080004295A1,CCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3ccn(S(=O)(=O)c4ccc(C)cc4)c3n2)cc1>>CCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3ccnc-3[nH]2)cc1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20080200501A1,CCOC(=O)c1nn(-c2ccc(C)cc2)c2c1C1CCC2C1>>Cc1ccc(-n2nc(C(=O)O)c3c2C2CCC3C2)cc1,,O,,[K+].[OH-],,val
US08598174B2,CC1(C)OB(c2ccc(F)c([N+](=O)[O-])c2)OC1(C)C>>CC1(C)OB(c2ccc(F)c(N)c2)OC1(C)C,[Pd],CCOC(C)=O,,,,val
US20070010511A1,CC(=O)Cl.COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCc2ccc3c(c2)N(CCN)CC3(C)C)cc1>>COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCc2ccc3c(c2)N(CCNC(C)=O)CC3(C)C)cc1,,CCN(CC)CC,ClCCl,,,val
US20140187786A1,CCOC(=O)C(CC(C)C)c1ccc(OCC)c(Br)c1.OB(O)c1ccc(C(F)(F)F)cc1>>CCOC(=O)C(CC(C)C)c1ccc(OCC)c(-c2ccc(C(F)(F)F)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05753709,C=CCI.CCCC(=O)NC[C@@H]1C[C@H]1c1cccc(O)c1>>C=CCOc1cccc([C@@H]2C[C@H]2CNC(=O)CCC)c1,,CCO,CCOCC,[K+].[OH-],,val
US20090137609A1,CCC(CC)(c1ccc(CCC(O)C(C)(C)C)c(C)c1)c1ccc(-c2ccc([C@@H](N)C(=O)OC)cc2)c(C)c1>>CCC(CC)(c1ccc(CCC(O)C(C)(C)C)c(C)c1)c1ccc(-c2ccc([C@@H](N)C(=O)O)cc2)c(C)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20100234340A1,COC(=O)c1ccc2c(c1)CN(Cc1ccccc1)C2.Cl>>COC(=O)c1ccc2c(c1)CN(Cc1ccccc1)C2.Cl,,ClCCl,,,,val
US20050032752A1,CCCCCNC(=O)OC[C@H]1CCC(=O)N1C/C=C\CCCC(=O)OC>>CCCCCNC(=O)OC[C@H]1CCC(=O)N1CCCCCCC(=O)OC,[Pd],CO,,,,val
US20160106754A1,Nc1ccc(OC(F)(F)F)cc1SSc1cc(OC(F)(F)F)ccc1N.O=C1CC(=O)NC2(CC2)C1>>O=C1NC2(CC2)CC2=C1Sc1cc(OC(F)(F)F)ccc1N2,CCN(CC)CC,CCO,,,,val
US06017910,CCOC(CBr)OCC.N[C@H](Cc1ccccc1)c1ccccc1>>CCOC(CN[C@H](Cc1ccccc1)c1ccccc1)OCC,,CN(C)C=O,ClCCl,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20050101614A1,Cl.Cn1cc2ccnc(-c3ccc(Cl)cc3Cl)c2n1>>Cl.Cn1cc2ccnc(-c3ccc(Cl)cc3Cl)c2n1,,CCOCC,CCOCC,,,val
US20030055071A1,CN1CCS(=O)(=O)NCC1=O.COC(=O)c1nc(Br)c2cccnc2c1O>>COC(=O)c1nc(N2CC(=O)N(C)CCS2(=O)=O)c2cccnc2c1O,O=[Cu-],c1ccncc1,,,,val
US20130059830A1,CC(C)(C)OC(=O)N(CC(O)c1cc(-c2ccc(Cl)cc2)nn1-c1ncccn1)C(CO)CCc1ccccc1>>CC(C)(C)OC(=O)N1CC(c2cc(-c3ccc(Cl)cc3)nn2-c2ncccn2)OCC1CCc1ccccc1,,Cc1ccccc1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120214762A1,C#CC(C)(O)c1ncccn1.Nc1nccc(-n2c(OCCO)nc3ccc(Br)cc32)n1>>CC(O)(C#Cc1ccc2nc(OCCO)n(-c3ccnc(N)n3)c2c1)c1ncccn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CS(C)=O,,CCN(CC)CC,,val
US05157038,C=C1N(C(C)C)C(=O)OC12CCNCC2.NC(=O)c1cccnc1Cl.O=C(Cl)C(=O)Cl>>C=C1N(C(C)C)C(=O)OC12CCN(C(=O)NC(=O)c1cccnc1Cl)CC2,,ClCCCl,,CCN(CC)CC,,val
US20020062041A1,ClCc1ccccc1.O.[C]=O>>O=C(O)Cc1ccccc1,Cl[Pd]Cl,,,CN1CCCC1=O,,val
US06291475B1,N#Cc1ccc(O)c([N+](=O)[O-])c1.O=[N+]([O-])c1cccc(S(=O)(=O)OCC2CO2)c1>>N#Cc1ccc(OCC2CO2)c([N+](=O)[O-])c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20070105904A1,C#Cc1cccnc1N.ON=C(Cl)Cc1ccc(Oc2cccc(F)c2)cc1>>Nc1ncccc1-c1cc(Cc2ccc(Oc3cccc(F)c3)cc2)no1,,O,,C1CCOC1,CCN(CC)CC,val
US20140378415A1,Cc1cc(C(=O)CC(S)(c2cc(Cl)cc(Cl)c2)C(F)(F)F)ccc1Br.NOS(=O)(=O)O>>Cc1cc(C2=NSC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1Br,,CCOC(C)=O,,[K+].[OH-],,val
US20150297586A1,ClCCCCn1cnc2ccccc21.c1ccc2nc(N3CCNCC3)cnc2c1>>c1ccc2nc(N3CCN(CCCCn4cnc5ccccc54)CC3)cnc2c1,,CC#N,,CCN(C(C)C)C(C)C,[I-].[K+],val
US20090124682A1,CC(=O)C(=O)O.Nc1cc(F)c(F)cc1I>>O=C(O)c1cc2cc(F)c(F)cc2[nH]1,,CN(C)C=O,,C1CN2CCN1CC2,,val
US08188277B2,O=C(Nc1ccc(Oc2ccc(C3OCCO3)cc2)c(F)c1)c1ccc(Cl)c(Cl)c1>>O=Cc1ccc(Oc2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2F)cc1,,CC(=O)O,,,,val
US07304051B2,COC(=O)c1ccc(I)cc1N.COC(=O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12.O=S(=O)(Cl)c1cccc2nsnc12.c1ccncc1>>O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1,,ClCCl,,Cl,,val
US03950376,BrCCc1ccsc1.Nc1cc(C(=O)O)cc(S)c1Oc1ccccc1>>Nc1cc(C(=O)O)cc(SCc2ccsc2)c1Oc1ccccc1,,[Na+],[OH-],,,val
US20110312945A1,CCOC(=O)Cn1c(C)c(Sc2ccc(S(=O)(=O)N3CCCC3)cc2)c2c1CCC(C)(C)C2>>Cc1c(Sc2ccc(S(=O)(=O)N3CCCC3)cc2)c2c(n1CC(=O)O)CCC(C)(C)C2,,C1CCOC1,O,[Na+].[OH-],,val
US05106871,COCOc1ccc(C=CC(=O)c2c(O)cc(OCOC)cc2OCOC)cc1>>COCOc1ccc(CCC(=O)c2c(O)cc(OCOC)cc2OCOC)cc1,[Pd],CCOC(C)=O,,[H][H],,val
US20090318486A1,CC(C)(C)OC(=O)CBr.O=C1Nc2ccc(Cl)cc2C1=O>>CC(C)(C)OC(=O)CN1C(=O)C(=O)c2cc(Cl)ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120264749A1,CC(C)(O)c1ccc(C(=O)OCc2ccccc2)cc1F>>CC(C)(O)c1ccc(C(=O)O)cc1F,[Pd],CO,,[H][H],,val
US20020143034A1,Cl.O=[N+]([O-])c1cccnc1Oc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1>>Cl.O=[N+]([O-])c1cccnc1Oc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1,,C1COCCO1,,,,val
US04316839,CN1Cc2c(C=O)ncn2-c2ccc(F)cc2C1=O.NO>>CN1Cc2c(C=NO)ncn2-c2ccc(F)cc2C1=O,,O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20130324573A1,CCCCCCCN=C=O.Oc1ccc2c(c1)N(Cc1ccccc1)CCC2>>CCCCCCCNC(=O)Oc1ccc2c(c1)N(Cc1ccccc1)CCC2,,C1CCOC1,,CCN(CC)CC,,val
US20060063759A1,Nc1nc2c(s1)C(=O)c1ccccc1CC2>>O=C1c2ccccc2CCc2ncsc21,,CN(C)C=O,,CC(C)CCON=O,,val
US20130023563A1,CC(C)(C)OC(=O)CBr.N#Cc1ccc2cc[nH]c2c1>>CC(C)(C)OC(=O)Cn1ccc2ccc(C#N)cc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050043544A1,CNC(=O)c1ccc2cc([C@@](O)(CC(=O)OC)c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)ccc2c1>>CNC(=O)c1ccc2cc([C@@](O)(CCO)c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)ccc2c1,,CCOC(C)=O,,Cl,O,val
US20020193367A1,CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccnn3CCOC3CCCCO3)c2)cc1C(F)(F)F>>CN(C)c1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3ccnn3CCO)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020161237A1,COC(=O)/C(=C/c1sc(C)nc1C)NC(=O)c1ccc(C(O)CCc2cccc(O)c2)cc1Cl>>Cc1nc(C)c(/C=C(\NC(=O)c2ccc(C(O)CCc3cccc(O)c3)cc2Cl)C(=O)O)s1,,C1CCOC1,CO,[Na+].[OH-],,val
US20050250810A1,CCOC(=O)/C=C/c1cnc(N)cc1C.Cl>>Cc1cc(N)ncc1/C=C/C(=O)O.Cl,,CC(=O)O,,,,val
US20150291636A1,CC(C)[Si](Cl)(C(C)C)C(C)C.CCSC(SCC)[C@@H](O)[C@@H](O)[C@H](O)CO>>CCSC(SCC)[C@@H](O)[C@@H](O)[C@H](O)CO[Si](C(C)C)(C(C)C)C(C)C,CN(C)c1ccncc1,O,c1ccncc1,,,val
US20160122341A1,Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)CC(=O)CC(C)(C)NC(=O)OC(C)(C)C)n2c1.NN>>Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(-c3cc(CC(C)(C)NC(=O)OC(C)(C)C)[nH]n3)n2c1,,CCO,,Cl,,val
US04970213,CCOC(=O)CC(=O)c1cc2cc(F)c(F)c(F)c2nc1Cl.COC(OC)N(C)C>>CCOC(=O)C(=CN(C)C)C(=O)c1cc2cc(F)c(F)c(F)c2nc1Cl,,CCOC(C)=O,,,,val
US05998406,CCSC(C)=S.NC[C@H]1CN(c2ccc(N3CCNC(=O)CC3)c(F)c2)C(=O)O1>>CC(=S)NC[C@H]1CN(c2ccc(N3CCNC(=O)CC3)c(F)c2)C(=O)O1,,CO,ClCCl,CCN(CC)CC,,val
US20140155407A1,O=C(n1ccnc1)n1ccnc1.OC(c1ccc(-c2ccoc2)nc1)C1CC1>>c1cn(C(c2ccc(-c3ccoc3)nc2)C2CC2)cn1,,CN1CCCC1=O,,,,val
US20090137595A1,CN(C)CC(=O)Nc1cn2nc(I)ccc2n1.Nc1cccc(O)c1>>CN(C)CC(=O)Nc1cn2nc(Oc3cccc(N)c3)ccc2n1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20060052315A1,CNCC(O)c1ccccc1.Cn1nc(-c2ccc(C=O)s2)cc1C(F)(F)F>>CN(Cc1ccc(-c2cc(C(F)(F)F)n(C)n2)s1)CC(O)c1ccccc1,,CC#N,CN(C)C=O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140288088A1,Cc1cc2[nH]c(=O)ccc2cc1C#N.O=P(Cl)(Cl)Cl>>Cc1cc2nc(Cl)ccc2cc1C#N,,O,,,,val
US20080096860A1,C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1.NS(N)(=O)=O>>C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1S(N)(=O)=O,,C1COCCO1,,,,val
US20090095343A1,CCCCCCCCCCOc1ccsc1.O=C1CCC(=O)N1Br>>CCCCCCCCCCOc1ccsc1Br,,ClC(Cl)Cl,,,,val
US20090253687A1,COC(=O)CCC(N)=O.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>COC(=O)CCC(N)=S,,C1CCOC1,,,,val
US20100144757A1,CCN.O=C(O)c1ccc(Cl)nc1Cl>>NCCc1nc(Cl)ccc1C(=O)O,,O,,,,val
US20060004017A1,COc1cc2c(Cl)ncnc2cc1OCCCN1CCN(C)CC1.Oc1cc2cc[nH]c2cc1F>>COc1cc2c(Oc3cc4cc[nH]c4cc3F)ncnc2cc1OCCCN1CCN(C)CC1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040152690A1,CC(=O)c1cnc(N2CCN(C(=O)OC(C)(C)C)CC2)c(Cl)c1.Cl>>CC(=O)c1cnc(N2CCNCC2)c(Cl)c1.Cl,,CCOC(C)=O,,,,val
US20080194647A1,N.O=C(Cl)c1cc(I)ccc1F>>NC(=O)c1cc(I)ccc1F,,CO,,,,val
US04511573,BrCCCCCCCCOC1CCCCO1.c1cncc(-c2cc3ccccc3[nH]2)c1>>OCCCCCCCCc1c(-c2cccnc2)[nH]c2ccccc12,,C1CCOC1,,CC[Mg]Br,,val
US20080311179A1,C=O.CC(=O)Cc1ccccc1>>C=C(C(C)=O)c1ccccc1,,CO,,C1CCNCC1,CC(=O)O,val
US20160038504A1,C1COCCN1.Clc1cc(Cl)c(Cl)nn1>>Clc1cc(N2CCOCC2)c(Cl)nn1,,CCO,,,,val
US20040038993A1,COC(=O)c1cc2ncc(-c3ccc(OCc4ccccc4)cc3)c(C3CCCCC3)n2n1.O=C1CCC(=O)N1Br>>COC(=O)c1nn2c(C3CCCCC3)c(-c3ccc(OCc4ccccc4)cc3)cnc2c1Br,,ClCCl,,,,val
US20020037905A1,NC(=O)N(c1cccc(C(F)(F)F)c1)c1ccc(N)cc1-c1nnn[nH]1.O=C(Cl)c1ccccc1>>NC(=O)N(c1cccc(C(F)(F)F)c1)c1ccc(NC(=O)c2ccccc2)cc1-c1nnn[nH]1,,C1CCOC1,,CCN(CC)CC,O,val
US20070270436A1,CC(=O)Cc1ccccc1F.CCOC(CBr)OCC>>CCOC(CC(C(C)=O)c1ccccc1F)OCC,,CN(C)C=O,,O,[H-].[Na+],val
US06235763B1,NC(N)=S.O=C1c2cc([N+](=O)[O-])ccc2CC1Br>>NC1=NC2(O)c3cc([N+](=O)[O-])ccc3CC2S1,,CC(C)=O,,,,val
US20150284395A1,CCn1nc(C)c2cc(C(=O)OC)ccc21>>CCn1nc(C)c2cc(C(=O)O)ccc21,,CO,O,[Na+].[OH-],,val
US20120115844A1,C[Si](C)(C)Cn1cc(-c2ccc(F)cc2)nn1>>Cn1cc(-c2ccc(F)cc2)nn1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20030008861A1,NCc1ccccc1.O=C(Cl)C(Br)CBr.OCc1ccccc1>>O=C(OCc1ccccc1)C1CN1Cc1ccccc1,,C1CCOC1,ClCCl,,,val
US04634465,CC1Cc2cc(Br)ccc2O1.O=S(=O)(O)Cl>>CC1Cc2cc(Br)cc(OS(=O)(=O)Cl)c2O1,,ClC(Cl)Cl,,,,val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.Oc1ccc2ncsc2c1I>>COc1cc2nccc(Oc3ccc4ncsc4c3I)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,,,val
US20050090534A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCSCCN>>CCSCCNC(=O)OC(C)(C)C,,C1CCOC1,,,,val
US05912247,O=C(OCc1ccccc1)N1CCN(c2nc(O[C@H]3C[C@@H](O)[C@H](O)[C@@H]3O)c3ccccc3n2)CC1>>O[C@H]1[C@H](O)C[C@H](Oc2nc(N3CCNCC3)nc3ccccc23)[C@H]1O,[Pd],CO,,,,val
US07179823B1,CCOC(=O)c1cn[nH]c1.Cc1oc(-c2ccccc2)nc1COc1ccc(CCl)cc1>>CCOC(=O)c1cnn(Cc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130084346A1,O=S(Cl)Cl.O=c1cc(CO)occ1OCc1ccccc1>>O=c1cc(CCl)occ1OCc1ccccc1,,CCOCC,,,,val
US20120095040A1,CC(C)(C)OC(=O)N1C[C@H]2CC[C@@H](O)[C@H]2C1.Oc1ccc(Cl)c2ccccc12>>CC(C)(C)OC(=O)N1C[C@H]2CC[C@H](Oc3ccc(Cl)c4ccccc34)[C@H]2C1,,C1CCCCC1,CCOC(C)=O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120040981A1,CC(C)(C)OC(=O)n1cc(B2OC(C)(C)C(C)(C)O2)cn1.Cc1c(Br)sc2c1N(C)C(C)(C)NC2=O>>Cc1c(-c2cn[nH]c2)sc2c1N(C)C(C)(C)NC2=O,,O,,COCCOC,O=C([O-])[O-].[Cs+].[Cs+],val
US20060241302A1,Cn1cnc(S(=O)(=O)Cl)c1.Nc1cc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)c(Cl)cn1>>Cn1cnc(S(=O)(=O)Nc2cc(C(c3cc(F)ccc3F)S(=O)(=O)c3ccc(Cl)cc3)c(Cl)cn2)c1,,CCOC(C)=O,CO,ClCCl,c1ccncc1,val
US20100075995A1,CCCC[C@H](C)Oc1nc(N)c2nc(OC)n(C3CCCCO3)c2n1.O=C(O)C(F)(F)F>>CCCC[C@H](C)Oc1nc2nc(OC)nc-2c(N)[nH]1.O=C(O)C(F)(F)F,,CO,,,,val
US06235929B1,CC(C)(C)OC(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)NCCc1ccccc1.O=S(=O)(Cl)Cc1ccccc1>>O=C(O)C[C@H](NS(=O)(=O)Cc1ccccc1)C(=O)NCCc1ccccc1,,CCOC(C)=O,ClCCl,,,val
US04241071,COC1(c2ccccc2Cc2ccccc2)CCN(C=O)CC1>>COC1(c2ccccc2Cc2ccccc2)CCN(C)CC1,,CCOCC,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US03933835,CCOC(=O)CCCSc1ccc(C23CC4CC(CC(C4)C2)C3)cc1>>O=C(O)CCCSc1ccc(C23CC4CC(CC(C4)C2)C3)cc1,,C1CCOC1,CCO,[Na+].[OH-],,val
US06057311,BrCc1ccccc1.CC(C)(C)OC(=O)N1CCc2c([nH]c3ccccc23)C1>>CC(C)(C)OC(=O)N1CCc2c(n(Cc3ccccc3)c3ccccc23)C1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20150259331A1,O=S(Cl)Cl.O=c1[nH]cnc2ccc(-c3ccc(S(=O)(=O)N4CCOCC4)cc3)cc12>>Cl.O=S(=O)(c1ccc(-c2ccc3ncnc(Cl)c3c2)cc1)N1CCOCC1,CN(C)C=O,,,,,val
US20100076026A1,CC(C)(C)OC(=O)CCc1ccc(N=C=O)c(F)c1.Clc1ccc(-n2nc3ccccc3c2NC2CCCCC2)cc1>>CC(C)(C)OC(=O)CCc1ccc(NC(=O)N(c2c3ccccc3nn2-c2ccc(Cl)cc2)C2CCCCC2)c(F)c1,,ClCCCl,,CCN(CC)CC,,val
US20150344473A1,Nc1ncnc(Cl)c1N.O=C(O)c1ccc(N2CCOCC2)nc1>>Clc1ncnc2[nH]c(-c3ccc(N4CCOCC4)nc3)nc12,,O=P(Cl)(Cl)Cl,,[Cl-].[NH4+],,val
US20100056511A1,CC(=O)Nc1ccc([N+](=O)[O-])cc1C(C)C>>CC(C)c1cc([N+](=O)[O-])ccc1N,,CCO,,Cl,,val
US20040033995A1,CCOC(=O)C=CC(Cc1cn(CC=Cc2ccccc2)cn1)NC(=O)CCCCCCc1ccccc1>>CCOC(=O)CCC(Cc1cn(CCCc2ccccc2)cn1)NC(=O)CCCCCCc1ccccc1,[Pd],CCO,,,,val
US20140094448A1,CC(C)(C)OC(=O)N(c1cc(Cl)nc2c(C=O)cnn12)C1CC1.O=C(O)c1ccc(B(O)O)s1>>CC(C)(C)OC(=O)N(c1cc(-c2ccc(C(=O)O)s2)nc2c(C=O)cnn12)C1CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20140315928A1,Cc1cccnc1N(C(=O)c1ccc(-c2cnn3cccnc23)cc1)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1.Cl>>Cc1cccnc1N(C(=O)c1ccc(-c2cnn3cccnc23)cc1)[C@@H]1CCCNC1.Cl,,C1COCCO1,,,,val
US20100216795A1,COc1ccc(Nc2nc(C(N)=O)c(NC(=O)c3ccc(F)c([N+](=O)[O-])c3)s2)cc1>>COc1ccc(Nc2nc(C(N)=O)c(NC(=O)c3ccc(F)c(N)c3)s2)cc1,[Fe],CCO,O,[Cl-].[NH4+],,val
US04007219,CN(C(=O)CNC(=O)[C@@H](N)Cc1ccccc1)c1ccc(Cl)cc1C(=O)c1ccccc1.Cl>>CN(C(=O)CNC(=O)[C@@H](N)Cc1ccccc1)c1ccc(Cl)cc1C(=O)c1ccccc1.Cl,,CO,,,,val
US20160272592A1,O=Cc1cc(Br)ccc1OC(F)F.OCCO>>FC(F)Oc1ccc(Br)cc1C1OCCO1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04435401,COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC.COc1ccc(Cl)nn1>>COc1cc2nc(N3CCN(c4ccc(Cl)nn4)CC3)nc(N)c2cc1OC,,CCCCCO,,CCN(CC)CC,,val
US04479953,COc1ccc(N)cc1.Nc1nc(Cl)c(Cl)nc1C=O>>COc1ccc(N=Cc2nc(Cl)c(Cl)nc2N)cc1,,CCO,,,,val
US20030232863A1,CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)O.Cc1ccccc1S(=O)(=O)OCC1(C)COC1>>CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)OCC1(C)COC1,,CN(C)C=O,O,[I-].[Na+],O=C([O-])[O-].[Cs+].[Cs+],val
US06204264B1,CCCCCCCCCCCCCCCCCc1nc2ccccc2n1CCN(C)C.Cl>>CCCCCCCCCCCCCCCCCc1nc2ccccc2n1CCN(C)C.Cl,,CCOC(C)=O,,,,val
US20120232061A1,CC(=O)c1ccc(OCc2cc(Cl)ccn2)c(-c2ccc3c(c2)CCN(C(=O)OC(C)(C)C)CC3)c1.CCO>>CCOc1ccnc(COc2ccc(C(C)=O)cc2-c2ccc3c(c2)CCN(C(=O)OC(C)(C)C)CC3)c1,,CCO,,O,CC(C)(C)[O-].[K+],val
US20040002504A1,CCn1nc(C)cc1C1CCN(CCC(N)c2ccccc2)CC1.ClCCl.O=S(=O)(Cl)c1ccc(Br)s1>>CCn1nc(C)cc1C1CCN(CCC(NS(=O)(=O)c2ccc(Br)s2)c2ccccc2)CC1.Cl,,ClCCl,,CCN(CC)CC,,val
US04711882,CCOC(=O)c1cc2c([nH]1)CNCC2.O=C(Cl)OCC(Cl)(Cl)Cl>>CCOC(=O)c1cc2c([nH]1)CN(C(=O)OCC(Cl)(Cl)Cl)CC2,,ClCCl,,CCN(CC)CC,,val
US04666915,CCOC(=O)c1cnc(Nc2ccc(OCC)c(OCC)c2)[nH]c1=O>>CCOc1ccc(Nc2ncc(C(=O)O)c(=O)[nH]2)cc1OCC,,CC(=O)O,,O,[Na+].[OH-],val
US20110201593A1,O=C(OCc1ccccc1)N1CCC(Nc2c([N+](=O)[O-])cnc3c2ccn3S(=O)(=O)c2ccccc2)CC1>>Nc1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1NC1CCN(C(=O)OCc2ccccc2)CC1,[Zn],CC(=O)O,,,,val
US20120142671A1,COC[C@@H](CNc1ccc(C#N)c(Nc2cc(C)ns2)c1)NC(=O)OC(C)(C)C.OO>>COC[C@@H](CNc1ccc(C(N)=O)c(Nc2cc(C)ns2)c1)NC(=O)OC(C)(C)C,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20130053364A1,COC(=O)c1c(CS(=O)(=O)c2ccccc2)ccc(-c2ccoc2)c1OCCN(C)C(=O)OC(C)(C)C>>CN(CCOc1c(-c2ccoc2)ccc(CS(=O)(=O)c2ccccc2)c1C(=O)O)C(=O)OC(C)(C)C,,C1COCCO1,O,[Li+].[OH-],,val
US20030139435A1,CN(CC(C)(C)C)c1nc(Cl)c(C#N)cc1F.CONC(=O)c1ccc(C)c(N)c1>>CONC(=O)c1ccc(C)c(Nc2nc(N(C)CC(C)(C)C)c(F)cc2C#N)c1,,CS(C)=O,,[F-].[K+],,val
US05134152,CCC(OS(C)(=O)=O)C(C)C(O)(Cn1cncn1)c1ccc(F)cc1F>>CC[C@@H]1O[C@@](Cn2cncn2)(c2ccc(F)cc2F)[C@H]1C,,CN(C)C=O,,[H-].[Na+],,val
US20140011783A1,CN1C(=O)c2c(nn(Cc3ccc(C(F)(F)F)cc3)c2Nc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CN1C(=S)c2c(nn(Cc3ccc(C(F)(F)F)cc3)c2Nc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12,,C1COCCO1,,,,val
US07442808B2,BrCc1cccc(I)c1.Oc1ccc2ccoc2c1>>Ic1cccc(COc2ccc3ccoc3c2)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US06225329B1,C=CC(=O)O.CC(C)CC=O.CC(C)N.[C-]#[N+]Cc1ccccc1>>C=C(C(=O)NC(C)C)C(CC(C)C)C(=O)NCc1ccccc1,,CO,,C1CCOC1,,val
US20120252780A1,CC(C)(C)OC(=O)N1CCC(C)(O)c2ccc(-c3cccc(C(F)(F)F)c3)nc21>>CC1=CCNc2nc(-c3cccc(C(F)(F)F)c3)ccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110288091A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(Cl)c(C=O)cnc21.CCOC(C)=O>>CCOC(=O)/C=C/c1cnc2[nH]ccc2c1Cl,,CCOC(C)=O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US04806538,CC(Br)c1cccc2ccccc12.CCOC(=O)C(NC(C)=O)C(=O)OCC>>CCOC(=O)C(NC(C)=O)(C(=O)OCC)C(C)c1cccc2ccccc12,,CCO,,C,C[O-].[Na+],val
US20090029994A1,CCI.CCOC(=O)Nc1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ncc(Br)cn1>>CCOC(=O)N(CC)c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ncc(Br)cn1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20150344446A1,CCOC(=O)Cc1cccc(B(O)O)c1.CCn1c(CCCc2cccc(Br)c2)nn(Cc2ccc(C(C)(C)C)cc2)c1=O>>CCn1c(CCCc2cccc(-c3cccc(CC(=O)O)c3)c2)nn(Cc2ccc(C(C)(C)C)cc2)c1=O,,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20030087926A1,C=Cc1cc(C)cc(C)c1.CCC(=O)C(=O)[O-].Nc1cc(Cl)cc(Cl)c1>>CCOC(=O)C1CC(c2cc(C)cc(C)c2)c2c(Cl)cc(Cl)cc2N1,,CC#N,,O=C(O)C(F)(F)F,,val
US20100204226A1,CCOC(=O)c1cnn(-c2nc3ccc(N)cc3c(=O)n2COCC[Si](C)(C)C)c1.O=C(Cl)c1ccccc1>>CCOC(=O)c1cnn(-c2nc3ccc(NC(=O)c4ccccc4)cc3c(=O)n2COCC[Si](C)(C)C)c1,,ClCCl,,,,val
US20160130254A1,CI.N#Cc1ccc(NC2CCCC(n3cncn3)C2)cc1C(F)(F)F>>CN(c1ccc(C#N)c(C(F)(F)F)c1)C1CCCC(n2cncn2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20040254241A1,COCOc1ccc(C=O)cc1.[C-]#[N+]CC(=O)OCC>>CCOC(=O)C(=Cc1ccc(OCOC)cc1)NC=O,,C1CCOC1,,CC(=O)O,[H-].[Na+],val
US05587487,CCOC(=O)Cn1c(I)c(I)c(I)c1I>>O=C(O)Cn1c(I)c(I)c(I)c1I,,C1COCCO1,,O,[Na+].[OH-],val
US20140364414A1,NNc1ccc(Br)cc1.O=CC(=O)O>>O=C(O)/C=N/Nc1ccc(Br)cc1,,O,,Cl,Cl,val
US20070010573A1,COC(=O)[C@@H](C)N.O=S1(=O)CCCO1>>COC(=O)[C@@H](C)NCCCS(=O)(=O)O,,CC#N,,,,val
US04299821,CCCCCCCCCCN.O=C(O)[C@@H]1CCCN1C(=O)OCc1ccccc1>>CCCCCCCCCCNC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1,,CN(C)C=O,,CC(C)COC(=O)Cl,CCN(CC)CC,val
US06479497B1,CN1CCN(c2cccc3c2C[C@H](N)CO3)CC1.COc1cc(N2CCOCC2)ccc1C(=O)O>>COc1c(C(N)=O)ccc(N2CCOCC2)c1[C@H]1COc2cccc(N3CCN(C)CC3)c2C1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20090298823A1,CCCCOC(=O)c1ccc(Nc2nc(N)c3c(-c4ccncc4)c[nH]c3n2)cc1>>Nc1nc(Nc2ccc(C(=O)O)cc2)nc2[nH]cc(-c3ccncc3)c12,,C1CCOC1,,[Li+].[OH-],,val
US20140308282A1,C1CCOC1.COC(=O)CCl.O=[N+]([O-])c1cccnc1>>CCOC(=O)Cc1ccncc1[N+](=O)[O-],,C1CCOC1,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US20120142668A1,COC(=O)/C=C/[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1cccs1)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@H](/C=C/C(=O)O)CCc1ccccc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US04980356,CCN(CC)C(=O)CCl.Nc1nc2ccc(OC(F)(F)F)cc2s1>>CCN(CC)C(=O)Cn1c(=N)sc2cc(OC(F)(F)F)ccc21,,CCC(C)=O,,[I-].[Na+],,val
US04607041,CCOC(=O)C1=C(C=O)NC(C(F)(F)F)=C(C(=O)OCC)C1c1cccc2nonc12>>CCOC(=O)C1=C(CO)NC(C(F)(F)F)=C(C(=O)OCC)C1c1cccc2nonc12,,CCO,,Cl,[BH4-].[Na+],val
US20160257668A1,COC(=O)Nc1ccc(-c2c[nH]c(C3NCC(C4CCN(C(=O)OC(C)(C)C)CC4)CC3C3CC3)n2)cc1.O=C(O)/C=C/c1cc(Cl)ccc1-n1cnnn1>>COC(=O)Nc1ccc(-c2c[nH]c(C3C(C4CC4)CC(C4CCN(C(=O)OC(C)(C)C)CC4)CN3C(=O)/C=C/c3cc(Cl)ccc3-n3cnnn3)n2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160108056A1,CC(C)(c1cccc(N)c1)c1cccc(C#N)c1.CS(=O)(=O)Nc1ccc2sc(C(=O)O)cc2c1>>CC(C)(c1cccc(C#N)c1)c1cccc(NC(=O)c2cc3cc(NS(C)(=O)=O)ccc3s2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06281363B1,CC(C)C[C@@H](C(=O)Nn1c(=O)[nH]c(=O)[nH]c1=O)[C@H](CCCc1ccccc1)C(=O)NOCc1ccccc1>>CC(C)C[C@@H](C(=O)Nn1c(=O)[nH]c(=O)[nH]c1=O)[C@H](CCCc1ccccc1)C(=O)NO,[Pd],CO,,,,val
US20070299057A9,Fc1ccc(CC2CCNCC2)cc1.O=CC1CCN(C(=O)OCc2ccccc2)C1>>O=C(OCc1ccccc1)N1CCC(CN2CCC(Cc3ccc(F)cc3)CC2)C1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05488061,C#CCCCCCCCCC.Fc1ccccc1Br>>CCCCCCCCCC#Cc1ccccc1F,[Cu]I,CCOC(C)=O,,C1CCOC1,CCN(CC)CC,val
US20050272763A1,COC(=O)C1(c2ccc(F)c(F)c2)Oc2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc2C1=O>>Oc1c(-c2ccc(F)c(F)c2)oc2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc12,,CCO,,[BH4-].[Na+],,val
US20100041891A1,O=C(O)c1cccc(-c2cccc3oc(Cc4cccc(C(F)(F)F)c4)cc23)c1>>O=C(O)c1cccc(-c2cccc3c2CC(Cc2cccc(C(F)(F)F)c2)O3)c1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20110098271A1,CC(N[S@](=O)C(C)(C)C)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12>>CC(N)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12,,C1COCCO1,,Cl,,val
US20090088430A1,CN=C=O.O=C1[C@H](Cc2c(Cl)cc(-c3ccc(F)cc3)cc2Cl)CCN1C1CCNCC1>>CNC(=O)N1CCC(N2CC[C@@H](Cc3c(Cl)cc(-c4ccc(F)cc4)cc3Cl)C2=O)CC1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20160031857A1,COC(=O)C1CSCC1=O.N=C(N)c1ccncc1>>Oc1nc(-c2ccncc2)nc2c1CSC2,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20090298823A1,Cc1ccc(S(=O)(=O)n2cc(I)c3c(Nc4ccc(F)cc4)nc(Cl)nc32)cc1.OB(O)c1ccncc1>>Cc1ccc(S(=O)(=O)n2cc(-c3ccncc3)c3c(Nc4ccc(F)cc4)nc(Cl)nc32)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20070276000A1,COCCl.COc1ccc2c(O)c(Br)c(C)cc2c1>>COCOc1c(Br)c(C)cc2cc(OC)ccc12,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080167356A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1CCl.COC(=O)c1cccc2cc(-c3ccc(O)cc3)ccc12>>COC(=O)c1cccc2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)cc3)ccc12,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06538000B1,O=C1CCC(=O)N1Br.O=C1CCCC2=C1C(c1ccc(Cl)c(Cl)c1)n1nccc1N2>>O=C1CCCC2=C1C(c1ccc(Cl)c(Cl)c1)n1ncc(Br)c1N2,,ClCCl,,,,val
US20060235033A1,COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.C[C@@H](N)c1ccc(F)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)N[C@H](C)c4ccc(F)cc4)c(C)c3C)c2cc1OC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20030199456A1,C=CCBr.O=C(NCCCCc1ccc(O)cc1)OCc1ccccc1>>C=CCOc1ccc(CCCCNC(=O)OCc2ccccc2)cc1,C1COCCOCCOCCOCCOCCO1,CC#N,,CC(C)(C)[O-].[K+],,val
US04146718,CCOC(=O)CNCc1c(N)ccc(Cl)c1Cl.N#CBr>>Br.CCOC(=O)CN1Cc2c(ccc(Cl)c2Cl)N=C1N,,Cc1ccccc1,,,,val
US20160264596A1,Brc1ccc(CC2CCCN2)cc1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCCC1Cc1ccc(Br)cc1,,ClCCCl,ClCCl,CCN(C(C)C)C(C)C,,val
US20060094754A1,CC(=O)CC(=O)C(F)(F)F.Nc1ccc(OC(F)(F)F)cc1C(=O)c1cccc(Cl)c1>>Cc1nc2ccc(OC(F)(F)F)cc2c(-c2cccc(Cl)c2)c1C(=O)C(F)(F)F,,CCCCCCC,CCOC(C)=O,CC(C)O,,val
US05045228,CCCCCCCCO.O=C(Cl)c1ccc(CBr)cc1>>CCCCCCCCOC(=O)c1ccc(CBr)cc1,,CCOC(C)=O,c1ccccc1,CCN(CC)CC,Cl,val
US20150344429A1,Cc1nc(C(C)(N)COCc2ccccc2)no1.O=C(O)c1cc(OCC(F)(F)F)c(C2CC2)cn1>>Cc1nc(C(C)(COCc2ccccc2)NC(=O)c2cc(OCC(F)(F)F)c(C3CC3)cn2)no1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US06136823,CN.Cc1c(F)c(F)cc2c(=O)c(C(=O)O)cn(-c3ccc(F)c(O)c3)c12>>CNc1c(F)cc2c(=O)c(C(=O)O)cn(-c3ccc(F)c(O)c3)c2c1C,,c1ccncc1,,,,val
US04689345,CCC(O)CCCCC1CCC2CC(=O)CC12>>CCC(=O)CCCCC1CCC2CC(=O)CC12,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20040102479A1,COc1ccc2c(c1)OCC(C)(c1ccncc1)C2CCCCCCCCCSCCCC(F)(F)C(F)(F)F>>c1ccc2c(c1)CC(c1ccncc1)CO2,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20120157460A1,Cn1c2c(c3ccc(-n4ccc(-c5ccc(C(F)(F)F)nn5)cc4=O)nc31)CN(C(=O)OC(C)(C)C)CC2>>Cn1c2c(c3ccc(-n4ccc(-c5ccc(C(F)(F)F)nn5)cc4=O)nc31)CNCC2,,CO,ClCCl,Cl,,val
US20080125468A1,CC(C)(C)OC(=O)CCNC(=O)c1ccc(OC(CC2CCCCC2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2)cc1.CI>>CN(CCC(=O)OC(C)(C)C)C(=O)c1ccc(OC(CC2CCCCC2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US04155913,NNC(=O)CO.S=C1CN=C(c2ccccc2Cl)c2cc(Cl)sc2N1>>OCc1nnc2n1-c1sc(Cl)cc1C(c1ccccc1Cl)=NC2,,CCCCO,,,,val
US20030176454A1,O=C(OO)c1cccc(Cl)c1.c1ccc(-c2cccc3cnccc23)cc1>>[O-][n+]1ccc2c(-c3ccccc3)cccc2c1,,ClCCl,,CCOC(C)=O,,val
US20130035326A1,CC(C)(CO)C(=O)CC#N.NO>>CC(C)(CO)c1cc(N)on1,,O,,Cl,[Na+].[OH-],val
US05516774,Cc1ccccc1C(=O)Nc1ccc(C(=O)Cl)cc1.Cc1nnc2n1-c1ccccc1NCC2>>Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3nnc(C)n3-c3ccccc32)cc1,,ClCCl,,CCN(CC)CC,,val
US05576324,Cc1c(C)c2c3c(cc(C)c2[nH]c1=O)CC(CN=[N+]=[N-])O3>>Cc1c(C)c2c3c(cc(C)c2[nH]c1=O)CC(CN)O3,[Pd],C1CCOC1,CO,[H][H],,val
US20120202776A1,COc1cc(P2(=O)CCN(Cc3ccccc3)CC2)ccc1[N+](=O)[O-]>>COc1cc(P2(=O)CCN(Cc3ccccc3)CC2)ccc1N,[Fe],O,,CCO,Cl,val
US20100137315A1,NCCc1cccc(Oc2ccccc2)c1.O=C(O)c1nc(-c2ccc(Cl)cc2)cs1>>O=C(NCCc1cccc(Oc2ccccc2)c1)c1nc(-c2ccc(Cl)cc2)cs1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20050203296A1,Cl.N#Cc1cc(C(F)(F)F)ccc1Nc1ccccc1[N+](=O)[O-]>>Cl.NC1=Nc2ccccc2Nc2ccc(C(F)(F)F)cc21,,CCO,Cl,Cl[Sn]Cl,,val
US20150299189A1,CO.O=C(O)c1nc(Br)ccc1Cl>>COC(=O)c1nc(Br)ccc1Cl,,O=S(=O)(O)O,,,,val
US04870074,CC(=O)NCC1CN(CCCOc2ccc(Cl)cc2)CCO1>>NCC1CN(CCCOc2ccc(Cl)cc2)CCO1,,[Na+],[OH-],,,val
US20060046999A1,C#CC(=O)OC.N=C(CC(=O)c1ccccc1)Nc1ccc(F)cc1>>Nc1c(C(=O)c2ccccc2)ccc(=O)n1-c1ccc(F)cc1,,CO,,,,val
US20070043028A1,C1CNCCNC1.CCOC(=O)CCCCBr>>CCOC(=O)CCCCN1CCCNCC1,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20110112133A1,Cc1ccn(-c2ccc(C(=O)N[C@@H]3CCC(F)(F)C[C@@H]3C(=O)N3CCc4c(-c5ccccc5)nc5ccc(F)cc5c43)cc2)n1.Cl>>Cc1ccn(-c2ccc(C(=O)N[C@@H]3CCC(F)(F)C[C@@H]3C(=O)N3CCc4c(-c5ccccc5)nc5ccc(F)cc5c43)cc2)n1.Cl,,CO,,,,val
US20120077840A1,CC(C)(C)[Si](C)(C)Cl.OC1CCCc2nc(Cl)ccc21>>CC(C)(C)[Si](C)(C)OC1CCCc2nc(Cl)ccc21,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)s2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2ncnn12.O=C([O-])O.[NH3+]O>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)s2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2ncnn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20130059834A1,CC(C)(C)N.Cn1nc(-c2cnc3[nH]cc(C(=O)O)c3n2)c2ccccc21>>Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c2ccccc21,,C1CCOC1,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20060014972A1,CCN(CC)C(F)(F)c1cccc(C)c1.O=C(OC[C@H]1O[C@H](OC(=O)c2ccccc2)[C@H](O)[C@@H]1OC(=O)c1ccccc1)c1ccccc1>>O=C(OC[C@H]1O[C@H](OC(=O)c2ccccc2)[C@H](F)[C@@H]1OC(=O)c1ccccc1)c1ccccc1,,CC#N,,,,val
US20120252805A1,CC1(C)OB(Cc2ccccc2)OC1(C)C.Cc1cc(NS(=O)(=O)c2cccc(Cl)c2)c2c(Br)c(C)sc2n1>>Cc1cc(NS(=O)(=O)c2cccc(Cl)c2)c2c(Cc3ccccc3)c(C)sc2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20100120741A1,N#Cc1ncccc1-c1ccc(Cl)cc1F.O>>O=c1[nH]c2cc(Cl)ccc2c2cccnc12,,O,,CO,[K+].[OH-],val
US06342504B1,COc1cccc(Br)c1OC>>Oc1cccc(Br)c1O,,Cc1ccccc1,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US05225570,C[N+](=O)[O-].O=Cc1cccnc1>>O=[N+]([O-])CC(O)c1cccnc1,,CCO,,CCNCC,,val
US20130072679A1,CN1C(=O)CCc2cc(-c3cncc(OCCNC(=O)OC(C)(C)C)c3)c(F)cc21.Cl>>CN1C(=O)CCc2cc(-c3cncc(OCCN)c3)c(F)cc21.Cl,,CO,,,,val
US20070270411A1,COc1ccc(N(C(=O)CN2C=CN(c3ccccc3)C(=O)C(=Cc3n[nH]c4ccccc34)C2=O)C(C)C)cc1>>CC(C)N(C(=O)CN1C=CN(c2ccccc2)C(=O)C(=Cc2n[nH]c3ccccc23)C1=O)c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,CO,val
US20020120011A1,Nc1cccc([N+](=O)[O-])c1.O=Cc1cccc(OC(F)(F)C(F)F)c1>>O=[N+]([O-])c1cccc(NCc2cccc(OC(F)(F)C(F)F)c2)c1,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20020120144A1,COC(OC)c1ccc(C=O)cc1F.O=C1CSC(=O)N1>>O=Cc1ccc(C=C2SC(=O)NC2=O)cc1F,,CCO,,C1CCNCC1,Cl,val
US04093812,CN(C)N.Cn1cc(C=O)c(-c2ccc([N+](=O)[O-])o2)n1>>CN(C)N=Cc1cn(C)nc1-c1ccc([N+](=O)[O-])o1,CC(=O)O,O,,CCO,,val
US20100167934A1,CCc1nc(Cl)nc(N)c1C#N.N[C@@H]1CCCc2ccccc21>>CCc1nc(N[C@@H]2CCc3ccccc32)nc(N)c1C#N,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20160130237A1,CNc1cc(Nc2ccc(OCCOC)cc2[N+](=O)[O-])ncn1.COc1cc(OC)c(Cl)c(N)c1Cl.O=C(Cl)Cl>>COCCOc1ccc(Nc2cc(N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)ncn2)c([N+](=O)[O-])c1,,C1COCCO1,CCOC(C)=O,Cc1ccccc1,,val
US20140378459A1,CC(C)(C)O.Cc1ccc2sc(C(=O)O)cc2c1>>Cc1ccc2sc(C(=O)OC(C)(C)C)cc2c1,,CCOC(C)=O,CN(C)C=O,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20110306618A1,CS(=O)(=O)NC1CCC(N)CC1.CS(=O)c1nccc(-c2cnc3c(C(C)(C)O)cccn23)n1>>CC(C)(O)c1cccn2c(-c3ccnc(NC4CCC(NS(C)(=O)=O)CC4)n3)cnc12,,CN1CCCC1=O,O,,,val
US20090227575A1,CN.Cn1ccc2c3nc(-c4ccc(N)cc4)nc(N4CCOCC4)c3ccc21.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3ccc4c(ccn4C)c3n2)cc1,,ClCCl,,C1CCOC1,CCN(CC)CC,val
US20020173506A1,CCOC(=O)CC(C)c1cc(N)ccn1.Cc1ccccc1Nc1nc2c(C)cc(CC(=O)O)cc2o1>>CCOC(=O)CC(C)c1ccc(NC(=O)Cc2cc(C)c3nc(Nc4ccccc4C)oc3c2)cn1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140213586A1,Cc1ccc(CC(=O)O)cn1.c1ccc2[nH]ccc2c1>>Cc1ccc(CC(=O)c2c[nH]c3ccccc23)cn1,,CCOC(C)=O,,CC(=O)OC(C)=O,,val
US20120114696A1,COC(=O)Cc1ccsc1Br.O=C(Cl)c1ccc(I)c([N+](=O)[O-])c1>>COC(=O)Cc1cc(C(=O)c2ccc(I)c([N+](=O)[O-])c2)sc1Br,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130143863A1,CC1(C)COC2(CCCc3c(N4C(=O)c5ccc(Cl)cc5C4(C)C)cncc32)OC1>>CC1(C)c2cc(Cl)ccc2C(=O)N1c1cncc2c1CCCC2=O,,CO,,C1COCCO1,Cl,val
US20070060589A1,COC(=O)c1ccccc1-c1cccc(CN)c1.C[C@H](NC(=O)OC(C)(C)C)C(=O)ON1C(=O)CCC1=O>>COC(=O)c1ccccc1-c1cccc(CNC(=O)C(C)NC(=O)OC(C)(C)C)c1,,ClCCl,O,CCN(CC)CC,,val
US20130065925A1,COc1ccc(COC(=O)C2(CC(=O)OC(C)(C)C)CN(C(=O)OCc3ccccc3)CC2C)cc1>>COc1ccc(COC(=O)[C@@]2(CC(=O)OC(C)(C)C)CN(C(=O)OCc3ccccc3)C[C@H]2C)cc1,,CCCCCC,CCO,,,val
US20150284381A1,C#CCCO.Clc1ccc(I)cc1Br>>OCCC#Cc1ccc(Cl)c(Br)c1,[Cu]I,CCN(CC)CC,,,,val
US20110034440A1,CC(C)(C)O.Cc1ccc(C(=O)O)cc1[N+](=O)[O-]>>Cc1ccc(C(=O)OC(C)(C)C)cc1[N+](=O)[O-],CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US20110144333A1,N#CBr.N[C@H](CO)CCOc1ccccc1>>NC1=N[C@@H](CCOc2ccccc2)CO1,,C1CCOC1,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US04886822,COc1ccc(Cl)c([N+](=O)[O-])c1.Sc1ccncc1>>COc1ccc(Sc2ccncc2)c([N+](=O)[O-])c1,,C1COCCO1,CCO,[H-].[Na+],,val
US05281617,CCC(C(=O)O)c1ccccc1.O=C1CCC(=O)N1O>>CCC(C(=O)OC1CC(=O)NC1=O)c1ccccc1,,C1COCCO1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20140142082A1,BrCC1CCCCC1.CCOC(=O)c1ccc(C)[nH]1>>CCOC(=O)c1ccc(C)n1CC1CCCCC1,,CN(C)C=O,,[H-].[Na+],O=C([O-])[O-].[K+].[K+],val
US20140135332A1,CC(=O)OCC(COC(C)=O)CC(Br)c1nc(-c2ccc(C(F)(F)F)cc2)c(Br)o1.NC(=O)c1c(F)ccc(O)c1F>>CC(=O)OCC(COC(C)=O)CC(Oc1ccc(F)c(C(N)=O)c1F)c1nc(-c2ccc(C(F)(F)F)cc2)c(Br)o1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20010027196A1,N#CCC(=O)C(C#N)=C(N)c1ccco1>>N#Cc1c(-c2ccco2)[nH]c(N)cc1=O,,CCO,,C,C[O-].[Na+],val
US20150158865A1,CC(C)(C)OC(=O)N1CCC(c2ccc(N)cc2)CC1.CCOC(=O)c1nnc(SC)nc1Cl.N>>CSc1nnc(C(N)=O)c(Nc2ccc(C3CCN(C(=O)OC(C)(C)C)CC3)cc2)n1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20070105904A1,CCCCOc1ccc(/C=C/[N+](=O)[O-])cc1>>CCCCOc1ccc(CC[N+](=O)[O-])cc1,,CS(C)=O,,CC(=O)O,[BH4-].[Na+],val
US20100093757A1,Cc1ccc(NC(=O)[C@@H](O)COC(C)C)nc1.Cn1ccnc1-n1ncc2c(Oc3ccccc3)ncnc21>>Cc1ccc(NC(=O)[C@H](COC(C)C)Oc2ncnc3c2cnn3-c2nccn2C)nc1,,C1CCOC1,,[H-].[Na+],,val
US20090239845A1,Cc1cc(NC(=O)c2ccc(CO)cc2)nn1Cc1cc(Br)ccc1OCC(C)C>>Cc1cc(NC(=O)c2ccc(C=O)cc2)nn1Cc1cc(Br)ccc1OCC(C)C,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090042966A1,CC(=O)N1N=C(c2cc(F)ccc2F)C[C@@]1(CCC(CF)NCc1ccccc1)c1ccccc1>>CC(=O)N1N=C(c2cc(F)ccc2F)C[C@@]1(CCC(N)CF)c1ccccc1,,CO,,,,val
US20030195354A1,CN(C)C(OC(C)(C)C)N(C)C.COc1cc(CCNC(=O)Cc2ccc3c(c2)CCCC3)ccc1OCc1ccccc1>>COc1cc(CCNC(=O)C(=CO)c2ccc3c(c2)CCCC3)ccc1OCc1ccccc1,,O,,CN(C)C=O,,val
US20130123235A1,CC1(C)C(=O)N(Br)C(=O)N1Br.COC(=O)C1C(=O)C=CCC1C>>COC(=O)c1c(C)ccc(Br)c1O,,ClCCl,,CC(C)NC(C)C,,val
US06734306B2,CC(C)(C)OC(=O)N1C2CCC1CNC2.O=C(O)CN1C(=O)c2ccccc2C1=O>>CC(C)(C)OC(=O)N1C2CCC1CN(C(=O)CN1C(=O)c3ccccc3C1=O)C2,,ClCCl,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20070213323A1,C=O.COc1ccc(-c2cnc(OC)cc2C)cc1>>COc1ccc(-c2cnc(OC)cc2CCO)cc1,,C1CCOC1,,[Li]CCCC,,val
US20140315961A1,C=NCC(=O)OCC.N#Cc1ccc(C(=O)Cl)cc1>>CCOC(=O)c1ncoc1-c1ccc(C#N)cc1,,Cc1ccccc1,,[H-].[Na+],,val
US20120264790A1,CCN(CC)S(F)(F)F.COC(=O)C1(NC(=O)c2ccc(C(C)=O)c(OCCc3cccc(C)c3)c2)CCCCCC1>>Cc1cccc(CCOc2cc(C(=O)NC3(C(=O)O)CCCCCC3)ccc2C(C)F)c1,,CO,,[BH4-].[Na+],,val
US20090209607A1,CC(C)(C)N(CC(Cc1ccccc1)N(OC(=O)c1cc(Br)cs1)C(=O)c1cc(Br)cs1)C(=O)[O-]>>CC(C)(C)OC(=O)NCC(Cc1ccccc1)N(O)C(=O)c1cc(Br)cs1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20130116250A1,CI.O=C(c1ccc2[nH]c(=O)n(Cc3ccc(F)cc3)c(=O)c2c1)c1nc(Br)c2ccccn12>>Cn1c(=O)n(Cc2ccc(F)cc2)c(=O)c2cc(C(=O)c3nc(Br)c4ccccn34)ccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060135447A1,CC(O)c1ccnc2ncccc12>>CC(=O)c1ccnc2ncccc12,,CCOC(C)=O,,,,val
US20100069310A1,CCc1ccc(Cc2cc(Br)c(OC)cc2NC(C)=O)cc1>>CCc1ccc(Cc2cc(Br)c(OC)cc2N)cc1,,CC(C)O,,Cl,,val
US20060094768A1,CS(=O)(=O)Cl.OCc1ccc(-c2ccc(C(F)(F)F)cc2)s1>>FC(F)(F)c1ccc(-c2ccc(CCl)s2)cc1,,ClCCl,,CCN(CC)CC,,val
US04103257,CCOC(=O)CC(=O)OCC.Nc1cccc(N)n1>>Nc1ccc2c(O)cc(=O)[nH]c2n1,,c1ccc(Oc2ccccc2)cc1,,,,val
US20070249051A1,CC1=C(c2ccc(NC(=O)c3c(F)cccc3F)cc2)CN(Cc2ccccc2)CC1.CCOC(=O)Cl>>CCOC(=O)N1CCC(C)=C(c2ccc(NC(=O)c3c(F)cccc3F)cc2)C1,,ClCCl,,,,val
US20090042852A1,CCOC(=O)c1cnc(N2CCNCC2)c(Cl)c1.Cc1ccc(S(=O)(=O)N=C=O)cc1>>CCOC(=O)c1cnc(N2CCN(C(=O)NS(=O)(=O)c3ccc(C)cc3)CC2)c(Cl)c1,,ClCCl,,,,val
US20120010223A1,Cn1c(S)cc(=O)n(C)c1=O.O=C(O)CC(=O)O>>Cn1c(=O)c2c(O)cc(=O)sc2n(C)c1=O,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20070032530A1,Cc1nc(-c2ccc(Cl)cc2)ccc1CCl.Oc1ccc(CCCCn2ccnn2)cc1>>Cc1nc(-c2ccc(Cl)cc2)ccc1COc1ccc(CCCCn2ccnn2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20070032469A1,CC1CCc2cc(F)cc([N+](=O)[O-])c2N1C=O>>CC1CCc2cc(F)cc([N+](=O)[O-])c2N1,,O,,CCO,[Na+].[OH-],val
US20070142331A1,Cc1ccc(CO)cc1.O=C1CCC(=O)O1>>Cc1ccc(COC(=O)CCC(=O)O)cc1,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070112037A1,CC(=O)C1CC1.O=Cc1ccc(OCc2ccccc2)cc1>>O=C(/C=C/c1ccc(OCc2ccccc2)cc1)C1CC1,,CCO,O,[Na+].[OH-],,val
US20090286765A1,CCCS(=O)(=O)c1ccc(/C=N/S(=O)C(C)(C)C)cc1.C[S+](C)(C)=O>>CCCS(=O)(=O)c1ccc(C2CN2S(=O)C(C)(C)C)cc1,,CS(C)=O,,[H-].[Na+],,val
US20110288084A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C2CN2S(=O)(=O)c2ccccc2[N+](=O)[O-])CC1.O=c1cnc2ccc(F)cc2[nH]1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C(Cn2c(=O)cnc3ccc(F)cc32)NS(=O)(=O)c2ccccc2[N+](=O)[O-])CC1,,CN(C)C=O,,[H-].[Na+],,val
US06084130,CCCN(CCC)C1Cc2cc(OCC)c(C(N)=O)cc2C1.FCCBr>>CCCN(CCC)C1Cc2cc(OCC)c(C(=O)NCCF)cc2C1,,CCCCCC,CN(C)C=O,[H-].[Na+],,val
US04697035,COc1ccc(C(Cl)C(C)C)cc1OC.[C-]#N>>COc1ccc(C(C#N)C(C)C)cc1OC,,CCN(CC)CC,O,[Na+].[OH-],,val
US20030139415A1,CC(=O)O.CCC(N)C(=O)O>>CCC(NC(C)=O)C(=O)O,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20150011774A1,CCOC(=O)ON=C(N)c1ccccc1-c1ccc(Cn2c(OCC)nc3cccc(C(=O)OCc4oc(=O)oc4C)c32)cc1>>CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CC(=O)CC(C)C,,,,val
US20110269780A1,Cc1cc(C)c2c(C(N)=O)nsc2c1.[OH-]>>Cc1cc(C)c2c(C(=O)O)nsc2c1,,CCO,O,Cl,,val
US20070142464A1,CC(=O)Oc1ccc(C#CC(O)(CC2(c3cc(C(F)(F)F)ccc3F)CC2)C(=O)Nc2ccc3c(c2)COC3=O)cc1>>O=C1OCc2cc(NC(=O)C(O)(C#Cc3ccc(O)cc3)CC3(c4cc(C(F)(F)F)ccc4F)CC3)ccc21,,CCOC(C)=O,CO,O=C([O-])O.[Na+],,val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2ccc(O[C@H]3CCCC[C@@H]3c3ccnn3C)c(Cl)c2F)c(OC)c1>>Cn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(S(=O)(=O)Nc2ccncn2)c(F)c1Cl,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20090105305A1,Cc1ccc([N+](=O)[O-])cc1C(=O)N1CCC(c2ccc(C#N)cc2)CC1>>Cc1ccc(N)cc1C(=O)N1CCC(c2ccc(C#N)cc2)CC1,[Pd],C1CCOC1,CCO,CCOC(C)=O,,val
US20130203727A1,C#CC(C)(C)C.CCOC(=O)C(OC(C)(C)C)c1c(C)cc2ccc(Br)cc2c1-c1ccc(Cl)cc1>>Cc1cc2ccc(C#CC(C)(C)C)cc2c(-c2ccc(Cl)cc2)c1C(OC(C)(C)C)C(=O)O,,CC#N,O,,,val
US20140349989A1,CCN(CC)CC.CCN=C=NCCCN(C)C.O=C(O)C1CNc2ccccc21.On1nnc2ccccc21>>O=C(C1CNc2ccccc21)N1CCN(C2CCCCC2)CC1,,CN(C)C=O,,,,val
US20120142916A1,CC(C)(C)OC(=O)N1C(=O)CC[C@H]1Cc1ccc(-c2ccccc2)cc1>>O=C1CC[C@@H](Cc2ccc(-c3ccccc3)cc2)N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140349282A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc(C(=O)O)cc1Br>>Cc1ccc(C(=O)OC(C)(C)C)cc1Br,CN(C)c1ccncc1,C1CCOC1,,,,val
US20130026452A1,Cc1cc(Br)ncc1Br.OB(O)c1cccc2c1oc1ccccc12>>Cc1cc(-c2cccc3c2oc2ccccc23)ncc1Br,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US04215216,C=CCn1c(=O)c(C(=O)OCC)c(Cl)c2cnc(-c3ccccc3)nc21.COCCN>>C=CCn1c(=O)c(C(=O)OCC)c(NCCOC)c2cnc(-c3ccccc3)nc21,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20120214762A1,C#C[Mg]Br.CC(=O)c1ncccn1>>C#CC(C)(O)c1ncccn1,,C1CCOC1,,,,val
US20050288287A1,CC(C)(C)OC(=O)N1CCNCC1.Cc1noc(C)c1C(=O)Cl>>Cc1noc(C)c1C(=O)N1CCNCC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070244092A1,CC(C)N.O=C(O)c1cc[nH]c1>>CC(C)NC(=O)c1cc[nH]c1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05389663,CC(=O)O[C@@](Cn1cncn1)(c1ccc(F)cc1F)[C@@H](C)S(=O)(=O)Cl.CCCCN>>CCCCNS(=O)(=O)C(C)=C(Cn1cncn1)c1ccc(F)cc1F,,ClCCl,,,,val
US20100035934A1,CNc1cc(Cl)nc(Nc2ccc(Cl)cc2)c1[N+](=O)[O-].Cc1cc(C)[nH]n1>>CNc1cc(-n2nc(C)cc2C)nc(Nc2ccc(Cl)cc2)c1[N+](=O)[O-],,C1CCOC1,,O,[H-].[Na+],val
US20160237095A1,COc1cccc2c1CNC2.Clc1nccc(Nc2ccc3[nH]ncc3c2)n1>>COc1cccc2c1CN(c1nccc(Nc3ccc4[nH]ncc4c3)n1)C2,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20020119977A1,COc1ccc(C=O)c(Br)c1OC.CSc1ccc(B(O)O)cc1>>COc1cc(C=O)c(-c2ccc(SC)cc2)cc1OC,,Cc1ccccc1,O,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20060004049A1,CO.Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@H](NC(=O)[C@H]2CCCN(C(=O)OC(C)(C)C)C2)C1>>CC(=O)N1CCC[C@H](C(=O)N[C@H]2CCCN(S(=O)(=O)c3cccc(Cl)c3C)C2)C1,,C1COCCO1,CO,Cl,O=C(O)C(F)(F)F,val
US05594145,Nc1nc2c(Cl)c(Cl)ccc2s1.O=N[O-]>>O=c1[nH]c2c(Cl)c(Cl)ccc2s1,,O,,Cl,,val
US05026836,NSc1nc(N)nc2c1ccn2[C@H]1C[C@H](O)[C@@H](CO)O1.O=C(OO)c1cccc(Cl)c1>>Nc1nc(S(N)=O)c2ccn([C@H]3C[C@H](O)[C@@H](CO)O3)c2n1,,CCO,,,,val
US20090023710A1,O=[N+]([O-])c1ccccc1Sc1ccncc1>>Nc1ccccc1Sc1ccncc1,[Fe],CCO,O,[Cl-].[NH4+],,val
US04983610,COC(=O)CCCCCCCCn1cc(-c2ccccc2)c(-c2ccccc2)nc1=O>>O=C(O)CCCCCCCCn1cc(-c2ccccc2)c(-c2ccccc2)nc1=O,,CO,,[Na+].[OH-],,val
US20100273764A1,COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(C(C)c4ccc(S(C)(=O)=O)cc4)cnc3Nc3cnc(OC)c(F)c3)n2)cc1>>COc1ncc(Nc2ncc(C(C)c3ccc(S(C)(=O)=O)cc3)cc2-c2nc(C)nc(N)n2)cc1F,,O=C(O)C(F)(F)F,,,,val
US20160002218A1,C=O.CC(=O)O.CCOC(=O)C1CCN(c2cnc(C(=O)Nc3nc(-c4ccc(OC)c(C(F)(F)F)c4)cs3)cn2)CC1>>CCOC(=O)C1CCN(c2cnc(C(=O)Nc3nc(-c4ccc(OC)c(C(F)(F)F)c4)c(COC(C)=O)s3)cn2)CC1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20110086846A1,CS(=O)(=O)c1cc([C@H](CC=O)NC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1.O>>CS(=O)(=O)c1cc([C@H](CC(=O)O)NC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1,,CC(C)(C)O,O,CC=C(C)C,[Na+].[O-]Cl,val
US04013692,COCCl.O=C(O)Cc1oc2cccc-2cc1-c1ccccc1>>COCOC(=O)Cc1oc2cccc-2cc1-c1ccccc1,,CN(C)C=O,,[K],,val
US20090143353A1,Cc1c(C#N)c(N)c(O)c(F)c1-c1ccccc1.O=C(Cl)C=Cc1ccccc1>>Cc1c(C#N)c(NC(=O)/C=C/c2ccccc2)c(O)c(F)c1-c1ccccc1,,CCOC(C)=O,,C1CCOC1,O=C([O-])O.[Na+],val
US20130041007A1,O=C1CCCCC1=NNc1ccc(Cl)cc1F>>O=C1CCCc2c1[nH]c1c(F)cc(Cl)cc21,,CC#N,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20090209571A1,CC(C)(C)[Si](C)(C)Cl.CC(C)(O)Cc1ccc2ccc3sc(Cl)cc3c2c1>>CC(C)(Cc1ccc2ccc3sc(Cl)cc3c2c1)O[Si](C)(C)C(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20090143361A1,COc1ccc2nc(C)c3c(C)nc(-c4cc(Cl)cc(Cl)c4)n3c2n1.Cc1ccc(B(O)O)cc1>>COc1ccc2nc(C)c3c(C)nc(-c4ccc(C)cc4)n3c2n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20100317655A1,NS(=O)(=O)c1sccc1C(=O)CBr>>O=S1(=O)NCC(O)c2ccsc21,,C1CCOC1,,Cl,[Na+].[OH-],val
US20040147580A1,BrCc1ccc2ccccc2c1.CN>>CNCc1ccc2ccccc2c1,,C1CCOC1,,O,,val
US20160016960A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc(C(=O)O)nn2c1-c1cc(F)c2c(c1C)CCCO2.Nc1ccc(Cl)cc1N>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc(-c3nc4cc(Cl)ccc4[nH]3)nn2c1-c1cc(F)c2c(c1C)CCCO2,CN(C)c1ccncc1,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060178514A1,CCN(CC1CCC1)c1nc2c(cc1C=O)c(C)nn2C.Cc1cc(N)no1>>CCN(CC1CCC1)c1nc2c(cc1CNc1cc(C)on1)c(C)nn2C,,CC(=O)O,ClC(Cl)Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160039821A1,C=O.Cn1cc(-c2cc(CS(C)(=O)=O)ccc2NCc2ccccc2OCC(N)=O)c2cc[nH]c2c1=O>>Cn1cc2c3c(c[nH]c3c1=O)CN(Cc1ccccc1OCC(N)=O)c1ccc(CS(C)(=O)=O)cc1-2,Cl[Ti](Cl)(Cl)Cl,C1CCOC1,,CCOC(C)=O,O=C([O-])O.[Na+],val
US20140073589A1,C[C@H](N)Cc1ccccc1.O=C(O)[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)CO>>C[C@@H](Cc1ccccc1)NC(=O)[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)CO,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110070193A1,CC(C)(C)OC(=O)Nc1ccc(N)cc1.O=S(=O)(Cl)CCCl>>C=CS(=O)(=O)Nc1ccc(NC(=O)OC(C)(C)C)cc1,,Cl,ClCCl,CCN(CC)CC,,val
US20020188000A1,COc1ccnc(N)c1.O=CCCl>>COc1ccn2ccnc2c1,,CCO,O,O=C([O-])O.[Na+],,val
US20110065725A1,COC(=O)c1nnn(-c2ccc(F)cc2)c1C.Nc1nccc(Cl)n1>>Cc1c(C(=O)Nc2nccc(Cl)n2)nnn1-c1ccc(F)cc1,,C1COCCO1,,C[Al](C)C,,val
US20140135316A1,CC1(C)OB(c2ccc(=O)[nH]c2)OC1(C)C.Cc1nnc2n1-c1ccc(Br)cc1N(c1ccc(S(C)(=O)=O)cc1)C[C@H]2C>>Cc1nnc2n1-c1ccc(-c3ccc(=O)[nH]c3)cc1N(c1ccc(S(C)(=O)=O)cc1)C[C@H]2C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040034034A1,C[C@@H]1CN(Cc2ccc(F)cc2)CCN1.O=C1COc2ccc(Cl)cc2O1>>C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1O,,Cc1ccccc1,,,,val
US04968340,CCOC(=O)C(OS(C)(=O)=O)C1=CCCC1.COc1cc(OC)nc(S)n1>>CCOC(=O)C(Sc1nc(OC)cc(OC)n1)C1=CCCC1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100216794A1,COCC(C)O.O=[N+]([O-])c1ncc(Cl)cc1O>>COCC(C)Oc1cc(Cl)cnc1[N+](=O)[O-],,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120083513A1,Cn1nnc2c(C(=N)SCC(=O)C(=O)O)ncn2c1=O.N>>Cn1nnc2c(-c3nc(C(N)=O)cs3)ncn2c1=O,,C1CCOC1,,CC(C)COC(=O)Cl,CCN(CC)CC,val
US08623859B2,CC(C)(C)OC(=O)NCCc1ccc(C2N[C@@H]3CCCC[C@H]3N2)cc1>>NCCc1ccc(C2N[C@@H]3CCCC[C@H]3N2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140024694A1,CCC(O)c1cccc(C#N)c1.CS(=O)(=O)Cl>>CCC(OS(C)(=O)=O)c1cccc(C#N)c1,,ClCCl,,CCN(CC)CC,,val
US20110144106A1,COC(=O)c1cc(Br)cc(I)c1.O=C1Nc2ccccc2[C@]12C[C@@H]2c1ccc(Cl)cc1>>COC(=O)c1cc(Br)cc(N2C(=O)[C@@]3(C[C@@H]3c3ccc(Cl)cc3)c3ccccc32)c1,[Cu]I,CC#N,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US05247042,CC(=O)OC(C)=O.CCCCN(CCCCO)c1ccc(C=O)cc1>>CCCCN(CCCCOC(C)=O)c1ccc(C=O)cc1,,ClCCl,,CCN(CC)CC,,val
US20050233988A1,CC(C)OB(OC(C)C)OC(C)C.FC(F)Oc1ccccc1>>OB(O)c1cccc(OC(F)F)c1,,C1CCOC1,,Cl,[Li]CCCC,val
US20140349919A1,COc1cc2c(c(O)c1C(=O)/C=C/c1ccc(O)cc1)CCC(C)(C)O2>>COc1cc2c(c(O)c1C(=O)CCc1ccc(O)cc1)CCC(C)(C)O2,[Pd],CO,,[H][H],,val
US20140364411A1,C[C@H]1CCC[C@@H](C)N1C(=O)Cl.NNc1ccc(F)cn1>>C[C@H]1CCC[C@@H](C)N1C(=O)NNc1ccc(F)cn1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US04625036,Fc1cc(C(F)(F)F)ccc1C1(Cn2cncn2)CO1.Fc1ccc(-c2nc[nH]n2)cc1>>OC(Cn1cncn1)(Cn1cnc(-c2ccc(F)cc2)n1)c1ccc(C(F)(F)F)cc1F,,CC(C)(C)O,,[H-].[Na+],,val
US20090171108A1,C[Si](C)(C)CC[Si](C)(C)O[Si](C)(C)CCCOCC1CO1.NCCOCCOCCO>>C[Si](C)(C)CC[Si](C)(C)O[Si](C)(C)CCCOCC(O)CNCCOCCOCCO,,CCO,,,,val
US20090062539A1,Br.CNc1nc(-c2cccc(NC(=O)c3ccc(C(=O)O)c(C)c3)c2)c2cc(OC)c(OC)cc2n1>>Br.CNc1nc(-c2cccc(NC(=O)c3ccc(C(=O)O)c(C)c3)c2)c2cc(OC)c(OC)cc2n1,,CC(C)O,,CS(C)=O,,val
US20100112090A1,CC(C)(C)[Si](C)(C)Cl.COc1cc(Cl)nc(CO)c1>>COc1cc(Cl)nc(CO[Si](C)(C)C(C)(C)C)c1,,CN(C)C=O,,O,c1c[nH]cn1,val
US04066695,NC(=S)Nc1c(Br)cccc1Br>>S=C=Nc1c(Br)cccc1Br,,Clc1ccccc1,,,,val
US20080306125A1,CCOC(=O)C(Cl)C(C)=O.COc1ccc(C(N)=S)cc1>>CCOC(=O)c1sc(-c2ccc(OC)cc2)nc1C,,CCO,,,,val
US20130023526A1,C=C[C@H]1CO[C@H](CO)CO1.CI>>C=C[C@H]1CO[C@H](COC)CO1,,C1CCOC1,O,[H-].[Na+],,val
US20060084687A1,Cc1ccc(NCc2ccccc2)c(NC(=O)C(NC(=O)OC(C)(C)C)C(C)C)c1>>Cc1ccc2c(c1)nc(C(NC(=O)OC(C)(C)C)C(C)C)n2Cc1ccccc1,,CC(=O)O,,,,val
US20080269220A1,CC(=O)OC(C)=O.COC(=O)CCc1ccc(NCc2cccc(-c3c(C)cccc3C)c2)cc1>>COC(=O)CCc1ccc(N(Cc2cccc(-c3c(C)cccc3C)c2)C(C)=O)cc1,,c1ccncc1,,,,val
US20060223801A1,COC(=O)c1cncc(Br)c1.O=C(OO)c1cccc(Cl)c1>>COC(=O)c1cc(Br)c[n+]([O-])c1,,ClCCl,,,,val
US20120171245A1,Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(NC[C@@H]4CCCC[C@H]4NC(=O)OC(C)(C)C)n3)c3cc(Cl)cnc32)cc1>>Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(NC[C@@H]4CCCC[C@H]4N)n3)c3cc(Cl)cnc32)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120010182A1,COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3ccc(-c4ccc(C(F)(F)F)cc4)cc3-c3ccnn3C3CN(C(=O)OC(C)(C)C)C3)cc2F)c(OC)c1>>O=S(=O)(Nc1nncs1)c1cc(Cl)c(Oc2ccc(-c3ccc(C(F)(F)F)cc3)cc2-c2ccnn2C2CNC2)cc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US04000151,CCOC(OCC)OCC.NNc1cc(-c2ccccc2)c2cc(Cl)ccc2n1>>Clc1ccc2c(c1)c(-c1ccccc1)cc1nncn12,,Cc1ccccc1C,,,,val
US20050228004A1,CC(=O)c1c(-c2ccc(F)cc2)nc2c([N+](=O)[O-])cccn12>>CC(=O)c1c(-c2ccc(F)cc2)nc2c(N)cccn12,[Fe],CO,,[Cl-].[NH4+],,val
US20100120810A1,CC(=O)Cl.COc1cc2cc(-c3ccccc3N)nc(C)c2cc1OC>>COc1cc2cc(-c3ccccc3NC(C)=O)nc(C)c2cc1OC,,ClCCl,,CCN(CC)CC,,val
US20100168418A1,CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCNCC1.O=CCn1c(=O)cc(Cl)c2ccccc21>>CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCN(CCn2c(=O)cc(Cl)c3ccccc32)CC1,,CC(=O)O,ClC(Cl)Cl,O=C([O-])O.[Na+],,val
US20100130558A1,O=S(=O)(Cl)c1cccc(C(F)(F)F)c1.c1ccc(CN2C[C@@H]3CC[C@H](NC4CC4)[C@@H]3C2)cc1>>O=S(=O)(c1cccc(C(F)(F)F)c1)N(C1CC1)[C@H]1CC[C@H]2CN(Cc3ccccc3)C[C@H]21,,C1CCOC1,,CCN(CC)CC,CN(C)c1ccccn1,val
US20130059834A1,CC1(NS(=O)C(C)(C)C)CCC(NC(=O)OC(C)(C)C)CC1.Cl>>CC1(N)CCC(NC(=O)OC(C)(C)C)CC1.Cl,,C1COCCO1,CO,,,val
US20040138462A1,CCOC(=O)Cc1ccc(Sc2ccc(C#N)cc2)cc1>>N#Cc1ccc(Sc2ccc(CC(=O)O)cc2)cc1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20020143182A1,CC(C)OB(OC(C)C)OC(C)C.COc1ccc(Br)cc1-c1ccccc1>>COc1ccc(B(O)O)cc1-c1ccccc1,,C1CCOC1,CCOCC,Cl,[Li]CCCC,val
US06432980B1,C[C@H]1OCC(=O)N[C@@H]1C(=O)N1CCC(c2cc(-c3ccncc3)c(-c3ccc(F)cc3)[nH]2)CC1>>C[C@H]1OCCN[C@H]1CN1CCC(c2cc(-c3ccncc3)c(-c3ccc(F)cc3)[nH]2)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20010034343A1,COC(=O)c1cc(-n2cnnc2SC)ccc1OC>>COc1ccc(-n2cnnc2SC)cc1C(=O)O,,C1CCOC1,Cl,O,[Li+].[OH-],val
US20080234255A1,CN1CCC(NC(=O)c2ccc([N+](=O)[O-])cc2)CC1>>CN1CCC(NC(=O)c2ccc(N)cc2)CC1,[Pd],C1CCOC1,,CCO,,val
US20130072473A1,CC(C)(C)OC(=O)N1CCc2c(sc(NC(=O)c3ccccc3Cl)c2C(N)=O)C1.O=C(O)C(F)(F)F>>NC(=O)c1c(NC(=O)c2ccccc2Cl)sc2c1CC[NH2+]C2.O=C([O-])C(F)(F)F,,ClCCl,,,,val
US05760021,BrCc1ccccc1.CN(C)CCC(O)(C(=O)O)P(=O)(O)O>>C[N+](C)(CCC(O)(C(=O)O)P(=O)(O)O)Cc1ccccc1.[Br-],,CCO,O,[Na+].[OH-],,val
US20030171411A1,Clc1ccc(NC2CCCC2)cc1Cl.Nc1nccs1.O=C(n1ccnc1)n1ccnc1>>O=C(Nc1nccs1)N(c1ccc(Cl)c(Cl)c1)C1CCCC1,,C1CCOC1,,,,val
US20100130495A1,CC(=O)N1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(OS(=O)(=O)C(F)(F)F)c2C1.N#CCCNC1CC1>>CC(=O)N1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(N(CCC#N)C3CC3)c2C1,,CS(C)=O,,,,val
US04997836,CCN(CC)CC.COc1cc2c(cc1OC)CCCC(C(=O)N1CCN(Cc3cc(OC)c(OC)c(OC)c3)CC1CO)=C2>>CCN(CC)CC1CN(Cc2cc(OC)c(OC)c(OC)c2)CCN1C(=O)C1=Cc2cc(OC)c(OC)cc2CCC1,,ClCCl,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US20130296293A1,CCOC(=O)C=C1CC(NC(=O)OC(C)(C)C)C1>>CCOC(=O)CC1CC(NC(=O)OC(C)(C)C)C1,[Pd],CO,,,,val
US04752645,COC(=O)C1C(=O)Nc2cccc(C(F)(F)F)c2CC1c1ccccc1OC>>COc1ccccc1C1Cc2c(cccc2C(F)(F)F)NC(=O)C1C(=O)O,,C1COCCO1,CO,[K+].[OH-],,val
US20050245532A1,COC(=O)C(C)(C)N1CCN(c2ccc(C(F)(F)F)cn2)CC1>>CC(C)(C(=O)O)N1CCN(c2ccc(C(F)(F)F)cn2)CC1,,C1COCCO1,,[K+].[OH-],,val
US20160272651A1,CCOC(=O)CBr.O=C1NCCN1c1ccc(Br)cc1Cl>>CCOC(=O)CN1CCN(c2ccc(Br)cc2Cl)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20090221555A1,CCI.O=[N+]([O-])c1ccc2c(c1)N1CCCC2CC1>>CCN1CC2CCC(C1)c1cc([N+](=O)[O-])ccc12,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040254378A1,C[C@@H](CO)CBr.Oc1cccnc1Br>>C[C@@H](CO)COc1cccnc1Br,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05747423,CN1N=C(C(F)(F)F)CC1=O.Cc1cc(Cl)nc(Cl)n1>>Cc1cc(Oc2cc(C(F)(F)F)nn2C)nc(Cl)n1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US05376670,COCCOCOc1c(C(C)(C)C)cc(C(=N)NN)cc1C(C)(C)C.S=C(n1ccnc1)n1ccnc1>>COCCOCOc1c(C(C)(C)C)cc(C2=NC(=S)N=N2)cc1C(C)(C)C,,C1CCOC1,,CCN(CC)CC,,val
US06358948B1,CC1(C)CC(=O)Nc2ccc(-c3cccc(F)c3)cc21.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CC1(C)CC(=S)Nc2ccc(-c3cccc(F)c3)cc21,,c1ccncc1,,,,val
US20140142114A1,CC(C)(C)OC(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1.Cl>>NCCN(CCCl)c1ccc2cc(Cl)ccc2n1,,CO,,,,val
US05744635,Cc1ccccc1B(O)O.OCCCO>>Cc1ccccc1B1OCCCO1,,C1CCCCC1,,,,val
US20130172302A1,O=C(CCl)c1cccs1.O=C(O[C@H]1CN2CCC1CC2)C(c1ccc(F)cc1)N1CCCCC1>>O=C(C[N+]12CCC(CC1)[C@@H](OC(=O)C(c1ccc(F)cc1)N1CCCCC1)C2)c1cccs1.[Cl-],,CCOC(C)=O,,CCOCC,,val
US03984552,COc1cccc(Cl)c1Cl.O=C(Cl)Cc1ccccc1>>COc1ccc(C(=O)Cc2ccccc2)c(Cl)c1Cl,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20140235628A1,O=C1OCc2cc(CCC3(O)CCN(C(=O)Cc4ccc(-n5cnnn5)cc4)CC3)ccc21>>O=C1OCc2cc(CCC3=CCN(C(=O)Cc4ccc(-n5cnnn5)cc4)CC3)ccc21,,c1ccccc1,,Cc1ccccc1S(=O)(=O)O,,val
US20100137317A1,COc1ccc(C2=C(c3ccc(OCc4ccc5ccccc5n4)cc3)C(=O)C(C)(C)O2)cc1>>CC1(C)OC(c2ccc(O)cc2)=C(c2ccc(OCc3ccc4ccccc4n3)cc2)C1=O,,C1CCOC1,O,Br,,val
US20050239802A1,CC(C)(C)O.Cc1ccc(I)cc1C(=O)O>>Cc1ccc(I)cc1C(=O)OC(C)(C)C,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCN=C=NCCCN(C)C,Cl,val
US20080125409A1,COc1ccc(-n2nc(C(=O)NC(C)(C)C)nc2-c2ccc(N)cn2)cn1.CS(=O)(=O)Cl>>COc1ccc(-n2nc(C(=O)NC(C)(C)C)nc2-c2ccc(NS(C)(=O)=O)cn2)cn1,,ClCCl,,c1ccncc1,O=C([O-])O.[Na+],val
US20110028390A1,Cc1cc(Br)cc(CO)c1F>>Cc1cc(Br)cc(C=O)c1F,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20060058295A1,Nc1cccnc1N.O=C(O)c1c(-c2ccccn2)nn2c1CCC2>>c1ccc(-c2nn3c(c2-c2nc4ncccc4[nH]2)CCC3)nc1,,Cl,,O=P(Cl)(Cl)Cl,,val
US20090286829A1,CCc1cccc2cccnc12.O=C1CCC(=O)N1Br>>CC(Br)c1cccc2cccnc12,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US06667336B2,CN(C/C=C(\I)c1ccc(Br)cc1)CC(=O)O.OB(O)c1ccsc1>>CN(C/C=C(/c1ccc(Br)cc1)c1ccsc1)CC(=O)O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20060122399A1,Brc1nccs1.CCc1cc(Br)ccc1O>>CCc1cc(Br)ccc1Oc1nccs1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150087639A1,CCNCC.Fc1cc(I)ccc1CBr>>CCN(CC)Cc1ccc(I)cc1F,,CCO,,,,val
US20070037794A1,COCN(c1cc(Cl)cnc1C(=O)c1ccnc(N)c1)S(=O)(=O)c1ccc(C)c(C(F)(F)F)c1.CS(=O)(=O)Cl>>Cc1ccc(S(=O)(=O)Nc2cc(Cl)cnc2C(=O)c2ccnc(NS(C)(=O)=O)c2)cc1C(F)(F)F,,c1ccncc1,,,,val
US20140275173A1,CC(C)(C)OC(=O)COCCC12CCC(c3cccc(OC4CCCCO4)c3)(CC1)OC2>>CC(C)(C)OC(=O)COCCC12CCC(c3cccc(O)c3)(CC1)OC2,,CO,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20060009453A1,CNc1nccc(-c2cccnc2Oc2ccc(N)cc2C)n1.COc1ccc(C2CCCCC2)cc1N=C=O>>CNc1nccc(-c2cccnc2Oc2ccc(NC(=O)Nc3cc(C4CCCCC4)ccc3OC)cc2C)n1,,Cc1ccccc1,,,,val
US20090093454A1,CCO.Cc1ccc(S(=O)(=O)O)cc1.O=C1CCCc2cccnc21.c1ccccc1>>CCOC(=O)CCC1CCc2cccnc2C1=O,,O,c1ccccc1,C1CCNC1,,val
US20060014945A1,CC(=O)O.N=C(NO)c1ccc(CN(C2CCCCNC2=O)S(=O)(=O)c2ccc(Cl)cc2)cc1>>Cc1nc(-c2ccc(CN(C3CCCCNC3=O)S(=O)(=O)c3ccc(Cl)cc3)cc2)no1,,CN(C)C=O,,O,O=C(n1ccnc1)n1ccnc1,val
US20160068510A1,CC(=O)c1ccnc(OC2CCC(C)N(C(=O)c3ccccc3-n3nccn3)C2)c1.CC[Mg]Br>>CCC(C)(O)c1ccnc(O[C@@H]2CC[C@@H](C)N(C(=O)c3ccccc3-n3nccn3)C2)c1,,C1CCOC1,,[Cl-].[NH4+],,val
US20130150364A1,CC(C)(C)OC(=O)N1CC[C@H](N)C1.CS(=O)(=O)c1nc(N2CCOCC2)cc(-n2c(C(F)F)nc3ccccc32)n1>>CC(C)(C)OC(=O)N1CC[C@H](Nc2nc(N3CCOCC3)cc(-n3c(C(F)F)nc4ccccc43)n2)C1,,O,,CC(=O)N(C)C,O=C([O-])[O-].[K+].[K+],val
US20150344429A1,CC(C#N)(CS(C)(=O)=O)NC(=O)OCc1ccccc1.NO>>CC(CS(C)(=O)=O)(NC(=O)OCc1ccccc1)C(=N)NO,,CCO,,CCN(CC)CC,Cl,val
US20150191461A1,COc1ccc(CN2C(=O)CC(CO)C2C)cc1.CS(=O)(=O)Cl>>COc1ccc(CN2C(=O)C[C@H](COS(C)(=O)=O)[C@H]2C)cc1,,ClCCl,,CCN(CC)CC,O,val
US05976858,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)OCC[SiH3].Cl>>Cl.N[C@@H](Cc1ccccc1)C(=O)OCC[SiH3],,C1COCCO1,,,,val
US05246948,O=C(NCCCSc1ccncc1)c1ccccc1CO>>O=C1c2ccccc2CN1CCCSc1ccncc1,,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US20030166697A1,BrCc1cccc(Br)c1.CCOC(=O)CC(=O)OCC>>CCOC(=O)C(Cc1cccc(Br)c1)C(=O)OCC,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20020028807A1,CCNc1nc(C(F)(F)F)ccc1NC(=O)c1cc(Br)cnc1Cl>>CCN1c2nc(C(F)(F)F)ccc2NC(=O)c2cc(Br)cnc21,,CN(C)C=O,O,[H-].[Na+],,val
US20120245210A1,Brc1cscc1Br.COc1ccc(B(O)O)cc1>>COc1ccc(-c2cscc2Br)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20130150360A1,Brc1cn2ccnc2c(Br)n1.CN1CCC(c2ccc(N)cc2)CC1>>CN1CCC(c2ccc(Nc3nc(Br)cn4ccnc34)cc2)CC1,,CC(C)O,,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US20080119457A1,COc1ccc2ccn(-c3ccc(C#N)c(NC4CCC(O)CC4)c3)c2c1.OO>>COc1ccc2ccn(-c3ccc(C(N)=O)c(NC4CCC(O)CC4)c3)c2c1,,CCOC(C)=O,CS(C)=O,CCO,[Na+].[OH-],val
US05744600,CCOP(=O)(CO[C@@H]1C=C[C@@H](O)C1)OCC.Cc1ccccc1S(=O)Cl>>CCOP(=O)(CO[C@@H]1C=C[C@@H](S(=O)c2ccccc2)C1)OCC,,ClCCl,,CCN(CC)CC,,val
US20140371199A1,CN(C(=O)OC(C)(C)C)C1CCNCC1.O=c1[nH]c2cc(Br)ccc2c(=O)o1>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(Br)cc2N)CC1,CN(C)c1ccncc1,,,CN(C)C=O,O,val
US20090202478A1,C1CCOC1.CS(C)=O.O=Cc1cccc(Br)c1>>O=C(O)CC/C=C/c1cccc(Br)c1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20140309222A1,Cc1ccc(N=C=O)cc1.Nc1nc(N2CCNCC2)c2c(-c3ccc(F)cc3)nsc2n1>>Cc1ccc(NC(=O)N2CCN(c3nc(N)nc4snc(-c5ccc(F)cc5)c34)CC2)cc1,,ClCCl,,,,val
US20070170394A1,OCCCCCCCl.Oc1ccc(-c2ccccc2)cc1>>OCCCCCCOc1ccc(-c2ccccc2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US06355642B1,COc1ccccc1N1CCNCC1.O=C1Nc2cccc3c2C1(CCBr)CCC3>>COc1ccccc1N1CCN(CCC23CCCc4cccc(c42)NC3=O)CC1,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US06207823B1,COC(=O)CC1c2ccccc2-c2c(O)cccc21>>OCCC1c2ccccc2-c2c(O)cccc21,,C1CCOC1,CCOCC,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160002188A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2ccccc2-c2cccc(N)c2)CC1.O=S(=O)(Cl)C1CCC1>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccccc2-c2cccc(NS(=O)(=O)C3CCC3)c2)CC1,,O,c1ccncc1,,,val
US20040043960A1,C#C[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21>>C#C[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)ncnc32)[C@H](O)[C@@H]1O,,CC(=O)O,O,,,val
US04797298,CC1SSC(C)C1N.C[C@@H](NC(=O)OC(C)(C)C)C(=O)[O-]>>CC1SSC(C)C1N(C(=O)OC(C)(C)C)[C@H](C)C(=O)O,,C1CCOC1,O,CCN(CC)CC,CCOC(=O)Cl,val
US20030060494A1,CN(C)C(=O)Cl.c1ccc(CSc2nc[nH]n2)cc1>>CN(C)C(=O)n1cnc(SCc2ccccc2)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20020082265A1,Cc1cc2c(cc1Br)C(C)(C)C=CC2(C)C.O.O=[Os](=O)(=O)=O>>Cc1cc2c(cc1Br)C(C)(C)[C@H](O)[C@H](O)C2(C)C,O=[Os](=O)(=O)=O,c1ccncc1,,O=S([O-])O.[Na+],,val
US20150152050A1,CCOC(=O)CP(=O)(OCC)OCC.O=CC1CC1>>CCOC(=O)C=CC1CC1,,CN(C)C=O,O,C1CCOC1,[H-].[Na+],val
US20120122840A1,Cc1cc(N2CCOCC2)ccc1Nc1nc(NC2CCCCC2)c2ncn(C3CCCCO3)c2n1>>Cc1cc(N2CCOCC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1,,CO,,CCOCC,Cl,val
US20080015226A1,CC(C)Cc1ccc([C@H](C)C(=O)Cl)cc1.COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)cc1OC>>COc1ccc(C(=Cc2c(Cl)cncc2Cl)OC(=O)[C@@H](C)c2ccc(CC(C)C)cc2)cc1OC,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20070155723A1,O=C1CCOCC1.O=Cc1ccc(F)cc1>>O=C1CCOCC1=Cc1ccc(F)cc1,,O,,Cl,[K+].[OH-],val
US20100048940A1,CC(O)CO.CCCC=O>>CC(O)CO.CCCC=O,[Pd],,,,,val
US20160024077A1,C=CCOc1cc(F)ccc1C#N>>C=CCOc1cc(F)ccc1CN,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130085157A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NNc1nc(-c2ccccc2)cs1>>CC(C)(C)OC(=O)N(Nc1nc(-c2ccccc2)cs1)C(=O)OC(C)(C)C,,ClCCl,,,,val
US05652237,CCOC(=O)c1ccccc1N.O=C=Nc1ccccc1I>>CCOC(=O)c1ccccc1NC(=O)Nc1ccccc1I,,C1CCOC1,,,,val
US04189595,O=C(O)Cc1ccccc1N(Cc1ccccc1)c1c(Cl)cccc1Cl>>O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl,,Clc1ccccc1Cl,,Cc1ccccc1,,val
US20100216813A1,C=O.N#Cc1ccc(N(Cc2ccccc2C(F)(F)F)[C@H]2CCNC2)cc1Cl>>CN1CC[C@H](N(Cc2ccccc2C(F)(F)F)c2ccc(C#N)c(Cl)c2)C1,,O,,[BH4-].[Na+],[Cl-].[NH4+],val
US20110015175A1,COc1cc(Nc2n[nH]c(C(CCCCCl)c3ccc(OCC(F)(F)F)cc3)n2)c(F)cc1-n1cnc(C)n1>>COc1cc(Nc2nc3n(n2)CCCCC3c2ccc(OCC(F)(F)F)cc2)c(F)cc1-n1cnc(C)n1,,CC(C)=O,,[I-].[Na+],,val
US20130324584A1,CC(C)C[C@@H](/C=C/C(=O)O)NC(=O)OC(C)(C)C.c1ccc2c(c1)CCN2>>CC(C)C[C@@H](/C=C/C(=O)N1CCc2ccccc21)NC(=O)OC(C)(C)C,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20110046133A1,Cc1cc(OCC(=O)N(C)C)cc(C)c1C=O.Cc1ccc(NC(=O)c2ccc(O)c(N)c2)cc1C>>Cc1ccc(NC(=O)c2ccc3oc(-c4c(C)cc(OCC(=O)N(C)C)cc4C)nc3c2)cc1C,,CO,,,,val
US05710170,CC(=O)O.COc1ccc([C@H](Cc2ccncc2)c2ccc(CC=O)cc2)cc1OC1CCCC1>>COc1ccc([C@H](Cc2ccncc2)c2ccc(CC(=O)O)cc2)cc1OC1CCCC1,CC(=O)O,CC(C)(C)O,O,CC=C(C)C,[Na+].[O-]Cl,val
US20160229853A1,O=[N+]([O-])c1cc(Cl)ccc1NC1CC2(C1)CS(=O)(=O)C2>>Nc1cc(Cl)ccc1NC1CC2(C1)CS(=O)(=O)C2,[Ni],CCO,,NN,O,val
US20050054683A1,CC(=O)NC[C@H]1CN(c2ccc(C3CN(C(=O)OCc4ccccc4)C3)c(F)c2)C(=O)O1>>CC(=O)NC[C@H]1CN(c2ccc(C3CNC3)c(F)c2)C(=O)O1,[Pd],CCO,CCOC(C)=O,,,val
US20060079526A1,CSC(=N)Nc1ccc(Cl)c(C(F)(F)F)c1.NNC(=O)c1cccc(O)c1>>Oc1cccc(-c2nnc(Nc3ccc(Cl)c(C(F)(F)F)c3)[nH]2)c1,,c1ccncc1,,I,,val
US20040092582A1,CCOC(=O)C(C)(C)NC(=O)c1cccc(C2=NC(C)(C)Cc3cc(OCC)c4c(c32)CC(C)(C)O4)c1.Cl>>CCOc1cc2c(c3c1OC(C)(C)C3)C(c1cccc(C(=O)NC(C)(C)C(=O)O)c1)=NC(C)(C)C2.Cl,,CCO,,[Na+].[OH-],,val
US09073882B2,O=[N+]([O-])c1ccc(CCBr)cc1.O=[N+]([O-])c1ccc(CCN2CCNCC2)cn1>>O=[N+]([O-])c1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cn3)CC2)cc1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20030065179A1,CCOC1=NCCN(C(=O)OCc2ccccc2)C1.NNC(=O)c1nc2ccccc2s1>>O=C(OCc1ccccc1)N1CCn2c(nnc2-c2nc3ccccc3s2)C1,,CCCCO,,,,val
US20130267493A1,COc1nc(Cl)ccc1Br.OC1CCNC1>>COc1nc(N2CCC(O)C2)ccc1Br,,O,,CCN(CC)CC,CS(C)=O,val
US20080188521A1,CCC(O)(c1cn(Cc2ccc3c(-c4ccc(F)cc4)cc(Cl)nc3c2)nn1)C(F)(F)F.[NH4+]>>CC[C@](O)(c1cn(Cc2ccc3c(-c4ccc(F)cc4)cc(N)nc3c2)nn1)C(F)(F)F,,[NH4+],[OH-],CN1CCCC1=O,,val
US20020133015A1,C=C(C)OC.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COC(C)=CC(=O)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US05684003,CC(=O)OC(C)=O.CC(C)CCON=O.CC(C)OC(=O)Cc1cc(OCc2ccccc2)ccc1N>>CC(=O)n1nc(C(=O)OC(C)C)c2cc(OCc3ccccc3)ccc21,,c1ccccc1,,CC(=O)[O-].[K+],,val
US20030144263A1,CS(=O)(=O)Cl.Cc1cn(-c2ccc(N3C[C@H](CO)OC3=O)cc2F)cn1>>Cc1cn(-c2ccc(N3C[C@H](COS(C)(=O)=O)OC3=O)cc2F)cn1,,c1ccncc1,,CCN(CC)CC,,val
US20100160322A1,CCOC(=O)c1ccc(F)cc1Oc1cc(C#C[Si](C)(C)C)c(N)cc1Cl>>C#Cc1cc(Oc2cc(F)ccc2C(=O)OCC)c(Cl)cc1N,,CO,,[Cs+].[F-],,val
US20110098251A1,O=C(O)C1CCOCC1.O=Cc1ccc(O)cc1>>O=Cc1ccc(OC(=O)C2CCOCC2)cc1,,ClCCl,O,O=S(Cl)Cl,c1ccncc1,val
US20030190298A1,O=C1CCC(c2ccc(O)cc2O)CC1.SCCS>>Oc1ccc(C2CCC3(CC2)SCCS3)c(O)c1,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US04279918,Clc1ccc(CC2CCCN2)cc1.O=C(O)[C@@](O)(C(=O)c1ccccc1)[C@@](O)(C(=O)O)C(=O)c1ccccc1>>Clc1ccc(CC2CCCN2)cc1.O=C(O)C(O)(C(=O)c1ccccc1)C(O)(C(=O)O)C(=O)c1ccccc1,,CC(C)=O,,,,val
US05348971,O=C(O)CCc1ccc(Cl)c(Cl)c1>>O=C1CCc2cc(Cl)c(Cl)cc21,,O=S(Cl)Cl,,,,val
US20100216836A1,O=C([C@H]1COc2ccccc2O1)N1CCC[C@H](c2cccc(F)c2)C1>>Fc1cccc([C@H]2CCCN(C[C@H]3COc4ccccc4O3)C2)c1,,C1CCOC1,,,,val
US05627197,CCOC(=O)CC(C(=O)OCC)N1CCN(CC2CN(c3ccc(C4=NOC(c5ccccc5)N4)cc3)C(=O)O2)CC1>>CCOC(=O)CC(C(=O)OCC)N1CCN(CC2CN(c3ccc(C(=N)NC(=O)c4ccccc4)cc3)C(=O)O2)CC1,,CO,,CCOC(C)=O,,val
US20010051620A1,COc1cc2cc3c(=O)c(C#N)c[nH]c3nc2cc1OC.O=P(Cl)(Cl)Cl>>COc1cc2cc3c(Cl)c(C#N)cnc3nc2cc1OC,,CCCCCC,,,,val
US20020119992A1,NCc1cc(Cl)ccc1C1CCN1C(=O)OCC(Cl)(Cl)Cl.O=C(O)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21>>O=C(NCc1cc(Cl)ccc1C1CCN1C(=O)OCC(Cl)(Cl)Cl)[C@@H]1CCCN1,,CN(C)C=O,,ClCCCl,On1nnc2cccnc21,val
US20140315889A1,C1COCCN1.C=C1CCc2c(c3cc(F)ccc3n2CCCCCCC(=O)OCC)C1=O>>CCOC(=O)CCCCCCn1c2c(c3cc(F)ccc31)C(=O)C(CN1CCOCC1)CC2,,Cc1ccccc1,,,,val
US20110053923A1,C[C@@H]1COCCN1c1cc(C2(S(C)(=O)=O)CCC2)nc(Cl)n1.OB(O)c1cccc2[nH]ccc12>>C[C@@H]1COCCN1c1cc(C2(S(C)(=O)=O)CCC2)nc(-c2cccc3[nH]ccc23)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20130109682A1,C=C1[C@H](O)C[C@H](c2ccncc2[N+](=O)[O-])OC12CC2.CC(C)(C)[Si](C)(C)Cl>>C=C1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](c2ccncc2[N+](=O)[O-])OC12CC2,,CN(C)C=O,,O,c1c[nH]cn1,val
US20070078135A1,COc1ncc(Br)c(OC)n1.OB(O)Oc1ccc(Cl)cc1>>COc1ncc(-c2ccc(Cl)cc2)c(OC)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20150005280A1,O=C(NC1CCC(N2CC[C@H](O)C2)CC1)OCc1ccccc1>>NC1CCC(N2CC[C@H](O)C2)CC1,,CO,,,,val
US20050171108A1,COC(OC)N(C)C.NS(=O)(=O)c1c(Cl)nc2ccc(Cl)nn12>>CN(C)C=NS(=O)(=O)c1c(Cl)nc2ccc(Cl)nn12,,Cc1ccccc1,,,,val
US04592866,CCNCC.CN1CC(CCCl)Oc2ncccc2C1=S>>CCN(CC)CCC1CN(C)C(=S)c2cccnc2O1,,CCO,,,,val
US20150072969A1,CCOC(=O)CC1(c2ccc(OCc3cccc(-c4ccc(OCC5(CO)COC5)cc4Cl)c3)cc2)COC1>>O=C(O)CC1(c2ccc(OCc3cccc(-c4ccc(OCC5(CO)COC5)cc4Cl)c3)cc2)COC1,,C1CCOC1,CO,O,[Li+].[OH-],val
US20120053180A1,CS(=O)(=O)Cl.CS(=O)(=O)c1ccc(-c2cc(F)c(OC3CCC(O)CC3)c(F)c2)cc1>>CS(=O)(=O)OC1CCC(Oc2c(F)cc(-c3ccc(S(C)(=O)=O)cc3)cc2F)CC1,,ClCCl,,CCN(CC)CC,,val
US20050143422A1,Cc1c(C(=O)O)oc2ccc(Br)c(OC(C)C)c12>>Cc1c(CO)oc2ccc(Br)c(OC(C)C)c12,,C1CCOC1,,B,,val
US20100173880A1,O=C(CBr)c1ccc(F)cc1F.O=C(O[C@H]1CN2CCC1CC2)C(Nc1ccccc1)c1ccccc1>>O=C(C[N+]12CCC(CC1)[C@@H](OC(=O)C(Nc1ccccc1)c1ccccc1)C2)c1ccc(F)cc1F.[Br-],,CC#N,,,,val
US20160060248A1,CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CO)n2C)c1ccccn1>>CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(C=O)n2C)c1ccccn1,O=[Mn]=O,CCCCCC,,ClCCl,,val
US20160194350A1,CC[C@H](OC(=O)c1ccccc1)[C@@H]1C[C@@H](C)C(=O)O1>>CC[C@H](OC(=O)c1ccccc1)[C@@H]1C[C@@H](C)C(O)O1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20150119373A1,COC1CCN(C(=O)[C@]23CC[C@@H](C4(C)CC4)[C@@H]2[C@H]2CC[C@H]4[C@@](C)(CC[C@H]5C(C)(C)[C@@H](OC(C)=O)CC[C@@]54C)[C@]2(C)CC3)CC1>>COC1CCN(C(=O)[C@]23CC[C@@H](C4(C)CC4)[C@@H]2[C@H]2CC[C@H]4[C@@](C)(CC[C@H]5C(C)(C)[C@@H](O)CC[C@@]54C)[C@]2(C)CC3)CC1,,C1COCCO1,,[Na+].[OH-],,val
US04938790,COc1ccccc1C(C)(C)c1ccccc1OC>>CC(C)(c1ccccc1O)c1ccccc1O,,CN(C)C=O,,CCOCC,[H-].[Na+],val
US20070249670A1,CC(C)(C)OC(=O)Nc1cc2ccccc2cc1C(=O)NC(C(=O)O)C1CCOCC1.Cl>>Cl.Nc1cc2ccccc2cc1C(=O)NC(C(=O)O)C1CCOCC1,,C1COCCO1,ClCCl,,,val
US20090270351A1,COC(=O)C(C(=O)OC)c1ccc(C(=O)OC(C)(C)C)cc1>>CC(C)(C)OC(=O)c1ccc(CC(=O)O)cc1,,C1CCOC1,,CO,[Na+].[OH-],val
US20160130268A1,CC(C)(C)OC(=O)NCCN1CCNCC1.CC(C)(O)CCl>>CC(C)(O)CN1CCN(CCNC(=O)OC(C)(C)C)CC1,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20160095858A1,Cc1cc(C)c(Cn2nc(C(C)(C)C)cc2C(=O)O)c(C)c1.NS(=O)(=O)c1cccc([N+](=O)[O-])c1>>Cc1cc(C)c(Cn2nc(C(C)(C)C)cc2C(=O)NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c(C)c1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06051716,C=Cc1ccc(N2C[C@H](CNC(C)=O)OC2=O)cc1F.COCN(Cc1ccccc1)C[Si](C)(C)C>>CC(=O)NC[C@H]1CN(c2ccc(C3CCN(Cc4ccccc4)C3)c(F)c2)C(=O)O1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040157865A1,NCc1ccc(C(F)(F)F)cc1.O=C(Nc1cccc2c(Cl)nccc12)Oc1ccccc1>>O=C(NCc1ccc(C(F)(F)F)cc1)Nc1cccc2c(Cl)nccc12,,CS(C)=O,,,,val
US20020137968A1,CC(C)(C)CCN.CCCCCCOc1ccc(C(=O)Cl)cc1.Oc1cccc2[nH]nnc12>>CCCCCCOc1ccc(C(=O)NCCC(C)(C)C)cn1,,CCOC(C)=O,CN(C)C=O,O,,val
US20140051679A1,NC(=O)c1ccc2[nH]nc(I)c2c1.NC(c1ccccc1Cl)C1CCCC1>>O=C(NC(c1ccccc1Cl)C1CCCC1)c1ccc2[nH]nc(I)c2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US03974162,CCOC(=O)CO.Clc1ccc(CNc2cc(Cl)nc(Cl)n2)cc1>>CCOC(=O)COc1nc(Cl)cc(NCc2ccc(Cl)cc2)n1,,C1CCOC1,,[H-].[Na+],,val
US20150065477A1,CCOC(=O)c1cccnc1-n1ccc(CN2CCOCC2)n1>>O=C(O)c1cccnc1-n1ccc(CN2CCOCC2)n1,,CO,O,,,val
US03985888,O=C(O)CCC1(c2ccccc2)CCC(=O)NC1=O>>O=C1CCC2(CCC(=O)c3ccccc32)C(=O)N1,,O=S(=O)(O)O,,,,val
US20140336108A1,Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCNC(=O)OC(C)(C)C)sc34)cc2)c1>>Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN)sc34)cc2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100298288A1,C/C=C(/C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NCC4CCN(c5nccc(C(F)(F)F)n5)CC4)cc3)oc12>>CCC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NCC4CCN(c5nccc(C(F)(F)F)n5)CC4)cc3)oc12,[Pd],CCOC(C)=O,,CO,ClCCl,val
US04214094,BrCc1ccccc1.CCOC(=O)C(C)(C)Oc1ccc(CNc2ccc(Cl)cc2)cc1>>CCOC(=O)C(C)(C)Oc1ccc(CN(Cc2ccccc2)c2ccc(Cl)cc2)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090258851A1,C1COCCN1.CC(C)C(C)(c1ccc(-c2cc(CBr)no2)cc1)c1ccc(OCc2ccccn2)cn1>>CC(C)C(C)(c1ccc(-c2cc(CN3CCOCC3)no2)cc1)c1ccc(OCc2ccccn2)cn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120283216A1,CCC(Br)C(=O)NC(C)(C)CO.COCBr>>CCC(Br)C(=O)NC(C)(C)COCOC,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040102497A1,COc1cc(NC(=O)CCl)ccc1-c1cnco1.Nc1ccccc1>>COc1cc(NC(=O)CNc2ccccc2)ccc1-c1cnco1,,CN(C)C=O,,,,val
US20110086854A1,CC(C)(C)CC1CNC(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.O=C(O)c1cccc(C(=O)O)c1>>CC(C)(C)C[C@@H]1CN(C(=O)c2cccc(C(=O)O)c2)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110275638A1,COC(=O)[C@@H](N)CCc1ccc(O)cc1.O=C(OCc1ccncc1)Oc1ccc([N+](=O)[O-])cc1>>COC(=O)[C@H](CCc1ccc(O)cc1)NC(=O)OCc1ccncc1,CN(C)c1ccncc1,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US04287337,CC(C)(C#N)CC(C)(C)CBr.[Li]CC>>CCC1=NCC(C)(C)CC1(C)C,,CCOCC,,,,val
US20070112019A1,NC(=O)c1cc(Cl)ccc1F.SCc1ccccc1>>NC(=O)c1cc(Cl)ccc1SCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US04560750,CCC(Br)(C=O)C(C)Br.Cn1nnnc1SCC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](N)[C@H]2SC1>>CCC(Br)(C=N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CSc3nnnn3C)CS[C@H]12)C(C)Br,,ClCCl,,O=S(=O)([O-])[O-].[Mg+2],,val
US04555578,COc1ccc(CON)cc1.O=C(O)Cn1nnnc1S>>COc1ccc(CONC(=O)Cn2nnnc2S)cc1,,CN(C)C=O,,Cl,,val
US20060079550A1,CC(C)CN[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O.O=C(Cl)c1ccccc1>>CC(C)CN(C(=O)c1ccccc1)[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O,,Cl,ClCCl,CCN(C(C)C)C(C)C,,val
US20140080810A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1nc2ccc(Br)cn2n1>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1nc2ccc(Br)cn2n1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20100240702A1,CCCC(CC(=O)OCC)Nc1cc(C)ccc1N.O=C(n1ccnc1)n1ccnc1>>CCCC(CC(=O)OCC)n1c(=O)[nH]c2ccc(C)cc21,,C1CCOC1,CCOC(C)=O,,,val
US20120309966A1,COc1cc(-c2nc([C@@H]3CC[C@@H](OC(C)=O)CC3)n3ccnc(C)c23)ccc1NC(=O)c1cc2c(OC)cccc2n1C>>COc1cc(-c2nc([C@@H]3CC[C@@H](O)CC3)n3ccnc(C)c23)ccc1NC(=O)c1cc2c(OC)cccc2n1C,,CC#N,O,Cl,[K+].[OH-],val
US06090805,CC(C)(C)OC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(C(F)(F)F)c2)CC1>>O=C(Cc1ccc(OC2CCNCC2)cc1C(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1,,CCOC(C)=O,,Cl,,val
US20160229816A1,CCOC(OCC)c1cccc(COc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1>>O=Cc1cccc(COc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20140206681A1,BrC1CC1.Oc1ccnc(Cl)c1>>Clc1cc(OC2CC2)ccn1,,CC(=O)N(C)C,,[I-].[Na+],O=C([O-])[O-].[Cs+].[Cs+],val
US20070043048A1,COc1ccc2c(-c3ccnc(NC4CC(C)(C)NC(C)(C)C4)n3)c[nH]c2c1>>CC1(C)CC(Nc2nccc(-c3c[nH]c4cc(O)ccc34)n2)CC(C)(C)N1,,ClCCl,,BrB(Br)Br,,val
US20120184539A1,CC(O)(COS(C)(=O)=O)c1nc(Br)ccc1F.[N-]=[N+]=[N-]>>CC(O)(CN=[N+]=[N-])c1nc(Br)ccc1F,,CCO,CCOC(C)=O,[Cl-].[NH4+],,val
US20160200725A1,COc1cc(OC)c(Cl)c(-c2cc3cnc(SC)nc3n(CCCN3[C@@H](C)CN(C(=O)OC(C)(C)C)C[C@H]3C)c2=O)c1.O=C(OO)c1cccc(Cl)c1>>COc1cc(OC)c(Cl)c(-c2cc3cnc(S(C)=O)nc3n(CCCN3[C@@H](C)CN(C(=O)OC(C)(C)C)C[C@H]3C)c2=O)c1,,ClCCl,,,,val
US20150157736A1,CC(C)(C)[Si](C)(C)O[C@@H](C(=O)NCCNC(=O)OCc1ccccc1)[C@H](O[Si](C)(C)C(C)(C)C)C(=O)NCCC(=O)OCc1ccccc1>>CC(C)(C)[Si](C)(C)O[C@@H](C(=O)NCCN)[C@H](O[Si](C)(C)C(C)(C)C)C(=O)NCCC(=O)O,[Pd],C1CCOC1,,,,val
US20120238517A1,CCN1CC(CO)CS1(=O)=O.O=C1NC(=O)c2ccccc21>>CCN1CC(CN2C(=O)c3ccccc3C2=O)CS1(=O)=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20010021718A1,CN(Cc1ccccc1)C(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1>>CN(Cc1ccccc1)C(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)O)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110003820A1,CC(=O)c1ccco1.NCCN>>CC1=NCCn2cccc21,,O,,Cl,O=C([O-])[O-].[K+].[K+],val
US05700819,Nc1c(F)c(F)cc(F)c1S.O=C1CCC(=O)O1>>O=C(O)CCc1nc2c(F)c(F)cc(F)c2s1,,CN1CCCC1=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20130225620A1,Cc1nc2c(C#N)cc(Cl)cc2n1C1CCCCO1>>Cc1nc2c(CN)cc(Cl)cc2n1C1CCCCO1,[Ni],CO,N,,,val
US20060128685A1,COc1ccc(-n2nc(C(=O)O)cc2-c2ccccc2)cn1>>COc1ccc(-n2nc(CO)cc2-c2ccccc2)cn1,,C1CCOC1,,CCOC(C)=O,O,val
US06346625B1,CCOC(=O)n1cc(-n2c(-c3cn(CCCOC(C)=O)c4ccccc34)c(C(N)=O)[nH]c2=O)c2ccccc21>>CCOC(=O)n1cc(-n2c(-c3cn(CCCOC(C)=O)c4ccccc34)c(C#N)[nH]c2=O)c2ccccc21,,ClCCl,,,,val
US08318928B2,CC(C)(C)COc1c(/C=C/c2nc3sccn3c2C(=O)O)cccc1OC(F)F.Nc1nc2c(s1)CCC2>>CC(C)(C)COc1c(/C=C/c2nc3sccn3c2C(=O)Nc2nc3c(s2)CCC3)cccc1OC(F)F,CN(C)c1ccncc1,C1CCOC1,CN(C)C=O,CCN=C=NCCCN(C)C,Cl,val
US05646173,CCOc1ccc2c(c1)C(=O)C(CC=O)C2.C[C@@H](O)CN>>CCOc1ccc2c(c1)-c1c(ccn1C[C@@H](C)O)C2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20070244092A1,C=CCN.CC(C)(C)c1nc2cc(S(=O)(=O)n3ccc(C(=O)O)c3)ccc2n1CC1CCOCC1>>C=CCNC(=O)c1ccn(S(=O)(=O)c2ccc3c(c2)nc(C(C)(C)C)n3CC2CCOCC2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160024082A1,Cc1nc2c(c(-c3ccnn3C3CCCCO3)n1)CC(C)N(C(C)c1ccccc1)C2>>Cc1nc2c(c(-c3ccnn3C3CCCCO3)n1)CC(C)NC2,[Pd],C1CCOC1,CO,O=C[O-].[NH4+],,val
US20040029877A1,COc1ccc(Cc2nc3c(N)nc4ccccc4c3n2CCCCN)cc1.CS(=O)(=O)OS(C)(=O)=O>>COc1ccc(Cc2nc3c(N)nc4ccccc4c3n2CCCCNS(C)(=O)=O)cc1,,CC#N,,ClCCl,,val
US20130150325A1,CS(=O)(=O)OCc1ccc(F)nc1.Cc1cc(/C(F)=C/c2ccc(N3CC(C)OC(C)C3)nc2)n[nH]1>>Cc1cc(/C(F)=C/c2ccc(N3CC(C)OC(C)C3)nc2)nn1Cc1ccc(F)nc1,,C1CCOC1,,CCOC(C)=O,CC(C)(C)[O-].[K+],val
US20090264437A1,C1CNCCN1.CC(C)(C)c1nc(Cl)cc(C2CC2)n1>>CC(C)(C)c1nc(C2CC2)cc(N2CCNCC2)n1,,CCO,,,,val
US20090137580A1,Cn1ccc2ncnc(Oc3ccc(N)c(Cl)c3)c21.O=C=Nc1ccc2ccccc2c1>>Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4ccc5ccccc5c4)c(Cl)c3)c21,,C1CCOC1,O,CCN(CC)CC,,val
US20150158815A1,C[Si](C)(C)C#N.Nc1cncc(Br)c1.O=Cc1cccc(Cl)c1>>N#CC(Nc1cncc(Br)c1)c1cccc(Cl)c1,,COCCOC,,,,val
US20060094761A1,CCN(CC)S(F)(F)F.Cc1ncc(CNc2ccc(C#N)cc2)c(CO)c1OCc1ccc(C#N)cc1>>Cc1ncc(CNc2ccc(C#N)cc2)c(CF)c1OCc1ccc(C#N)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20050032786A1,CC(C)(C)OC(=O)CCc1cccc(C#N)n1.O=C(O)c1ccc(F)cc1S>>CC(C)(C)OC(=O)CCc1cccc(-c2nc(=O)c3ccc(F)cc3s2)n1,,c1ccncc1,,,,val
US20100075965A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(Nc1cn2cc(I)ccc2n1)c1ccc(F)nc1>>CC(C)(C)OC(=O)N1CCN(c2ccc(C(=O)Nc3cn4cc(I)ccc4n3)cn2)CC1,,CC#N,,,,val
US20070129347A1,CC(Cc1c[nH]c2ccccc12)NC(=O)C=C1CCC(c2ccccc2)(N(C)C)CC1.C[Si](C)(C)Cl>>CC(Cc1c[nH]c2ccccc12)NC(=O)C=C1CCC(c2ccccc2)(N(C)C)CC1.Cl,,CCC(C)=O,,,,val
US20150023913A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@@H](NCCOCc1ccccc1)C(C)(C)C>>COC(=O)[C@@H](N(CCOCc1ccccc1)C(=O)OC(C)(C)C)C(C)(C)C,,C1COCCO1,,,,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4nnc(SCC)n4CC(C)C)cc2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4nnc(SCC)n4CC(C)C)cc2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20090118325A1,CC(=O)O[C@H]1C(O)SC[C@@H](OC(C)=O)[C@@H]1OC(C)=O.CC(C)(C)OC(=O)n1ccc2cc(O)ccc21>>CC(=O)O[C@H]1C(Oc2ccc3c(ccn3C(=O)OC(C)(C)C)c2)SC[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070281933A1,CC(C)(C)OC(=O)N1CCC(c2n[nH]c3c(C(N)=O)cc(Br)cc23)CC1.OB(O)c1cccs1>>CC(C)(C)OC(=O)N1CCC(c2n[nH]c3c(C(N)=O)cc(-c4cccs4)cc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US06498165B1,CC(Nc1nccc(-n2cnc3ccccc32)n1)c1cn(C(=O)OC(C)(C)C)c2ccccc12>>CC(Nc1nccc(-n2cnc3ccccc32)n1)c1c[nH]c2ccccc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US04495195,COC(=O)C(=O)CC(=O)c1cccc(C(F)(F)F)c1.O=N[O-]>>COC(=O)C(=O)C(=NO)C(=O)c1cccc(C(F)(F)F)c1,,CO,,Cl,,val
US20080167329A1,Nc1ccc(Cl)cc1C(=O)c1ccc(Br)cc1.O=C(n1ccnc1)n1ccnc1>>O=C(c1ccc(Br)cc1)c1cc(Cl)ccc1NC(=O)n1ccnc1,,ClCCl,,CCOCC,O,val
US20100252433A1,CCCc1c[nH]c(CCC(=O)OCC)c1.COC(OC)OC>>CCCc1cc(CCC(=O)OCC)[nH]c1C=O,,ClCCl,O=C(O)C(F)(F)F,O,[Na+].[OH-],val
US20150307507A1,CCc1cc(-c2cnc(C(=O)OC(C)(C)C)s2)cc[n+]1[O-]>>CCc1cc(-c2cnc(C(=O)OC(C)(C)C)s2)ccn1,[Pd],CCO,,,,val
US20100152188A1,N#Cc1ccc(N=C=O)cc1.Nc1ccccc1NC(=O)Cc1csc(NC(=O)OCc2ccncc2)n1>>N#Cc1ccc(NC(=O)Nc2ccccc2NC(=O)Cc2csc(NC(=O)OCc3ccncc3)n2)cc1,,C1CCOC1,,,,val
US20110306595A1,O=C(O)C1CN(Cc2ccccc2)CC12CCCc1ccccc12.c1ccc(C2CCNCC2)cc1>>O=C(C1CN(Cc2ccccc2)CC12CCCc1ccccc12)N1CCC(c2ccccc2)CC1,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20100273754A1,CN1C(=O)c2c(n[nH]c2Nc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12.ICC1CCOCC1>>CN1C(=O)c2c(Nc3ccccc3)nn(CC3CCOCC3)c2N2C1=N[C@@H]1CCC[C@@H]12,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US03953397,O=C(Cl)c1cc(Cl)c(Cl)c(Cl)c1Cl.O=C1NC(=O)C2C1CCC(Br)C2Br>>O=C(c1cc(Cl)c(Cl)c(Cl)c1Cl)N1C(=O)C2CCC(Br)C(Br)C2C1=O,,c1ccccc1,,c1ccncc1,,val
US20100227880A1,OCc1nc2ccccn2c1-c1ccc(N2CCOCC2)nc1>>O=Cc1nc2ccccn2c1-c1ccc(N2CCOCC2)nc1,,ClCCl,,,,val
US06723722B1,CCOC(=O)c1cc(Cl)cc(C)n1>>Cc1cc(Cl)cc(CO)n1,,CO,,[BH4-].[Na+],,val
US20130143863A1,CCOC(=O)C1CCCN(C(=O)OC(C)(C)C)C1.Clc1cncc(Cl)n1>>CCOC(=O)C1(c2cncc(Cl)n2)CCCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20120010188A1,Nc1ncc(Cl)cc1Cl.O=C(CBr)c1ccc(Br)cc1>>Clc1cc(Cl)c2nc(-c3ccc(Br)cc3)cn2c1,,CCO,,,,val
US20080221148A1,COc1cc(CO)ncc1OCc1ccc(Cl)cc1>>COc1cc(C=O)ncc1OCc1ccc(Cl)cc1,,CS(C)=O,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090030003A1,CC[C@@H]1CNC[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1.Cc1cnc(C=O)cn1>>CC[C@@H]1CN(Cc2cnc(C)cn2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1,,CN(C)C=O,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140148487A1,CCCCCCCCCCCCCCCCBr.COC(=O)c1cc(O)cc(C(=O)OC)c1>>CCCCCCCCCCCCCCCCOc1cc(C(=O)OC)cc(C(=O)OC)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060094843A1,CCOC(=O)C1(CC(C)C)CCCC1O.O=C(Cl)c1ccccc1>>CCOC(=O)C1(CC(C)C)CCCC1OC(=O)c1ccccc1,,c1ccncc1,,ClCCl,,val
US20100210591A1,CCOC(=O)C=Cc1ccc(NC(=O)c2cc([Si](C)(C)C)cc([Si](C)(C)C)c2)cc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)C=Cc1ccc(NC(=S)c2cc([Si](C)(C)C)cc([Si](C)(C)C)c2)cc1,,Cc1ccccc1,,,,val
US20140094495A1,CN1CC(C)(CO)NC1=O.O=S(Cl)Cl>>CN1CC(C)(CCl)NC1=O,,ClCCCl,,c1ccncc1,,val
US04285867,COC(=O)c1cccc(O)c1.ClCc1ccccc1>>COC(=O)c1cccc(OCc2ccccc2)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20070010668A1,Nc1ccccc1C(=O)c1ccccc1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>O=C(c1ccccc1)c1ccccc1Nc1nc(Cl)ncc1[N+](=O)[O-],,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US03946031,S=C(Nc1nc2ccccc2[nH]1)c1ccoc1>>c1ccc2c(c1)nc1nc(-c3ccoc3)sn12,,ClC(Cl)Cl,,BrBr,,val
US08871782B2,CCOCc1nc2c(N)nc3cc(OCCCCCCNC(=O)OC(C)(C)C)ccc3c2n1CC(C)(C)NC(=O)NC(C)C>>CCOCc1nc2c(N)nc3cc(OCCCCCCN)ccc3c2n1CC(C)(C)NC(=O)NC(C)C,,Cl,,CCO,,val
US20140128390A1,CC(C)(C)OC(=O)N1CCN(c2ncnc3cc(N4CCOCC4)sc23)CC1.Cl>>Cl.c1nc(N2CCNCC2)c2sc(N3CCOCC3)cc2n1,,C1COCCO1,CC#N,,,val
US20090163714A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.C[Si](C)(C)CCOCn1cnc(-c2cccc(C(F)(F)F)c2)c1>>CC(C)(C)OC(=O)N1CCC(O)(c2nc(-c3cccc(C(F)(F)F)c3)cn2COCC[Si](C)(C)C)CC1,,ClCCl,,C1CCOC1,[Li]CCCC,val
US20150361065A1,COC(=O)/C=C/c1ccc(OC2=C(c3ccc(OC)cc3)S(=O)c3cc(OC)ccc32)cc1>>COC(=O)/C=C/c1ccc(Oc2c(-c3ccc(OC)cc3)sc3cc(OC)ccc23)cc1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20080076806A1,CC(C)(C)OC(=O)NCC(=O)NC(c1ccccc1)c1ccc(Cl)cc1.Cl>>Cl.NCC(=O)NC(c1ccccc1)c1ccc(Cl)cc1,,CCOCC,,,,val
US05952327,CC(Cc1ccccc1)OP(=O)(O)CC1(C(=O)O)CCCC1.CCO>>CCOP(=O)(O)CC1(C(=O)O)CCCC1,[Pd],CCO,,[H][H],,val
US20130116430A1,CC(C)(C)O.Cc1nc2ccc(C(=O)O)cc2o1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cc1nc2ccc(NC(=O)OC(C)(C)C)cc2o1,,C1COCCO1,,CCN(CC)CC,,val
US20080261969A1,CCOC(=O)c1[nH]ccc1N.O=C1CCCC(=O)C1.O=Cc1ccc(Sc2nc3ccc(Cl)cc3[nH]2)o1>>CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3cc(Cl)ccc3[nH]2)o1,,CCO,,,,val
US20130236932A1,O=C[C@@H](O)[C@H](O)[C@H](O)CO.OCC(O)CO>>O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,,OCC(O)CO,,CCO,,val
US20150376181A1,N.NC(=O)c1cnc(Cl)cc1Cl>>NC(=O)c1cnc(Cl)cc1N,,C1COCCO1,,,,val
US04891363,BrC(Br)(Br)Br.COCCOCOCCCCCO>>COCCOCOCCCCCBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160083403A1,CC1(C)OB(c2cc(C(=O)Cl)ccc2C(Br)Br)OC1(C)C.COc1cccc(C(=O)NNC(C)(C)C)c1C>>COc1cccc(C(=O)NN(C(=O)c2ccc(C(Br)Br)c(B3OC(C)(C)C(C)(C)O3)c2)C(C)(C)C)c1C,,ClCCl,O,O=C([O-])[O-].[K+].[K+],,val
US07109225B2,CC(C)NC(C)C.CCOCC(=O)OCC.Cc1oc(C(C)(C)C)nc1COc1ccc(C=O)c2sccc12.[Li]CCCC>>CC(C)[N-]C(C)C.CCOC(=O)C(OCC)C(O)c1ccc(OCc2nc(C(C)(C)C)oc2C)c2ccsc12.[Li+],,C1CCOC1,,,,val
US20130296301A1,BrCc1ccccc1.CN(C)C1=N[C@H]2[C@H](O[C@H]([C@@H](O)C3SCCCS3)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)S1>>CN(C)C1=N[C@H]2[C@H](O[C@H]([C@@H](OCc3ccccc3)C3SCCCS3)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)S1,,CN(C)C=O,,[H-].[Na+],,val
US20160060267A1,CCOC(=O)C(C(=O)CCc1ccccc1)C(C)C.N#Cc1c[nH]nc1N>>CC(C)c1c(CCc2ccccc2)[nH]c2c(C#N)cnn2c1=O,Cl[Ti](Cl)(Cl)Cl,Cc1ccccc1,,,,val
US20040186103A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.COc1ccc([N+](=O)[O-])cc1Br>>COc1ccc([N+](=O)[O-])cc1C1=CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100087424A1,CC(C)(C)OC(=O)NC1CCN(C[C@@H]2COc3c(F)cnc4ccc(=O)n2c34)CC1.O=C(O)C(F)(F)F>>NC1CCN(C[C@@H]2COc3c(F)cnc4ccc(=O)n2c34)CC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20060116383A1,CCOC(=O)CC(c1ccccc1)n1cnc2ccc(N)cc21.O=C(Cl)c1cccc([N+](=O)[O-])c1>>CCOC(=O)CC(c1ccccc1)n1cnc2ccc(NC(=O)c3cccc([N+](=O)[O-])c3)cc21,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20130040930A1,CI.Cc1ccc(N2CCN(C(=O)c3ccc(N4CCCS4(=O)=O)cc3NC(=O)OC(C)(C)C)CC2)c(C)c1>>CNc1cc(N2CCCS2(=O)=O)ccc1C(=O)N1CCN(c2ccc(C)cc2C)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US20140094465A1,COC(=O)c1ccc(CC(=O)c2ccc(O)cc2)cc1>>O=C(O)c1ccc(CC(=O)c2ccc(O)cc2)cc1,,C1COCCO1,,Cl,,val
US04150052,CC1CCC(C(C)C)C(C(=O)Cl)C1.NCC#CCO>>CC1CCC(C(C)C)C(C(=O)NCC#CCO)C1,,CCOCC,O,Cl,O=C([O-])O.[Na+],val
US20040176416A1,COC(=O)C1CCC(N)CC1O>>O=C1NC2CCC1C(O)C2,,Cc1cc(C)cc(C)c1,,CC(=O)O,,val
US05158952,CC(C)NC(C)C.Fc1ccc2c(C3CCNCC3)noc2c1.O=c1c(CCCl)cnc2n1CCCC2O>>Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O,,CO,,Cl,,val
US20020052369A1,C1CCNC1.O=C(Br)CBr>>O=C(CBr)N1CCCC1,,ClCCl,,CCN(CC)CC,,val
US20100267992A1,C1N2CN3CN1CN(C2)C3.CC(C)(C)c1cccc(C(C)(C)C)c1O.O>>CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O,,CC(=O)O,,,,val
US20050090483A1,CCOC(C)=O.COC(C=O)OC>>CCOC(=O)C=CC(OC)OC,,C1CCOC1,,O,O=C([O-])[O-].[K+].[K+],val
US20160052922A1,COc1cc(O)cc(-c2nc(N3CCOCC3)c3cnn(C(C)C)c3n2)c1.ClCC1CO1>>COc1cc(OCC2CO2)cc(-c2nc(N3CCOCC3)c3cnn(C(C)C)c3n2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04962234,CCOC(=O)c1ccc(N=C(C)c2ccccc2)cc1>>CCOC(=O)c1ccc(NC(C)c2ccccc2)cc1,[Pd],CCO,,,,val
US20120135999A1,BrC1CCC1.CN(C)C=O.Clc1cc2cc[nH]c2cn1>>N#Cc1cn(C2CCC2)c2cnc(Cl)cc12,,O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070167421A1,CCOC(=O)C(Cc1ccccc1)C(=O)OCC.Cl.N=C(N)c1ccccn1>>Cl.O=C1N=C(c2ccccn2)NC(=O)C1Cc1ccccc1,,CCO,CO,Cl,C[O-].[Na+],val
US20110082181A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4cc(C)no4)cc3)cc2)CC1.O=C1CCC(=O)N1Br>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4Br)cc3)cc2)CC1,,CC(=O)O,,,,val
US04644010,N#CCC(=O)c1ccc[nH]1.O=C=Nc1ccc(Cl)cc1Cl>>N#CC(C(=O)Nc1ccc(Cl)cc1Cl)C(=O)c1ccc[nH]1,,COCCOC,,CCN(CC)CC,,val
US20100048666A1,CC(C(=O)O)c1ccc(CC2CSCC2=O)cc1>>CC(C(=O)O)c1ccc(CC2CSCC2O)cc1,,CCO,,[BH4-].[Na+],,val
US06107301,Cc1cc(C)c([N+](=O)[O-])c(C)n1>>Cc1cc(C)c(N)c(C)n1,[Pd],CO,,,,val
US20040087798A1,Nc1cccc(Cc2ccncc2)c1.O=C(O)c1cccc2c1Cc1ccccc1-2>>O=C(Nc1cccc(Cc2ccncc2)c1)c1cccc2c1Cc1ccccc1-2,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20120264923A1,CC(=CCCCOC[C@H](O)[C@H](O)CO)CCCC(C)CCCC(C)CCCC(C)C.CC(=CCCCO[C@@H](CO)[C@H](O)CO)CCCC(C)CCCC(C)CCCC(C)C.O>>CC(=CCCCOC[C@H](O)[C@H](O)CO)CCCC(C)CCCC(C)CCCC(C)C.CC(=CCCCO[C@@H](CO)[C@H](O)CO)CCCC(C)CCCC(C)CCCC(C)C.O,,O,,,,val
US20100179109A1,CN.COC(=O)c1ccc(CBr)cc1Br>>CNCc1ccc(C(=O)OC)c(Br)c1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20110014142A1,CC(=O)OC(C)=O.C[C@@H](O)C1CCCCC1>>CC(=O)O[C@H](C)C1CCCCC1,Cc1ccc(S(=O)(=O)O)cc1,,,,,val
US20100174113A1,NCc1ccccc1.O=S(=O)(F)C(F)(F)Sc1ccccc1>>O=S(=O)(NCc1ccccc1)C(F)(F)Sc1ccccc1,,ClCCCl,,Cl,,val
US05595995,CC(=O)c1cccnc1.[Li]C>>CC(C)(O)c1cccnc1,,C1CCOC1,CCOCC,,,val
US20100093748A1,Clc1ncnc2[nH]cnc12.N#CC1(c2nc3ccccc3[nH]2)CCNCC1>>N#CC1(c2nc3ccccc3[nH]2)CCN(c2ncnc3[nH]cnc23)CC1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20090018166A1,CC(C)(C)OC(=O)C1CCN(c2nc(CN3CCCCC3=O)c(C(=O)C3CC3)cc2C#N)CC1>>N#Cc1cc(C(=O)C2CC2)c(CN2CCCCC2=O)nc1N1CCC(C(=O)O)CC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20150031668A1,COC(=O)c1cccc(S(=O)(=O)Cl)c1.N[C@]1(c2ccc(OC(F)(F)F)c(F)c2)CCOc2cccnc21>>COC(=O)c1cccc(S(=O)(=O)N[C@]2(c3ccc(OC(F)(F)F)c(F)c3)CCOc3cccnc32)c1,,ClCCl,,Cl,,val
US20160185775A1,Brc1ccccn1.OCc1c(F)cccc1F>>Fc1cccc(F)c1COc1ccccn1,,C1CCOC1,O,[H-].[Na+],,val
US20130252934A1,CCOC(=O)/C=C/c1ccc(Cl)c(F)c1>>OC/C=C/c1ccc(Cl)c(F)c1,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20160176848A1,CC(C)(C)OC(=O)NCC[C@@H]1Cc2ccccc2CN1C(=O)c1cc2c(cc1-c1cc(C(=O)N(c3ccccc3)c3ccc(O[Si](C)(C)C(C)(C)C)cc3)c3n1CCCC3)OCO2.Cl>>Cl.NCC[C@@H]1Cc2ccccc2CN1C(=O)c1cc2c(cc1-c1cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3n1CCCC3)OCO2,,C1COCCO1,CO,[K+].[OH-],,val
US05081246,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O.c1ccc(N2CCNCC2)cc1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCN(c2ccccc2)CC1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20090286827A1,CCCCc1c([Si](C)(C)C)nnn1-c1cnc(Nc2ccc(Cl)cc2)c(Cl)c1>>CCCCc1cnnn1-c1cnc(Nc2ccc(Cl)cc2)c(Cl)c1,,C1CCOC1,CCOC(C)=O,,,val
US20110065708A1,COC(=O)C1(c2ccc3ncccc3c2)CC1.NN>>NNC(=O)C1(c2ccc3ncccc3c2)CC1,,CO,,O,,val
US20140213786A1,CC(=O)Nc1ncc(Cl)cc1F.O=CN1CCOCC1>>CC(=O)Nc1ncc(Cl)c(C=O)c1F,,C1CCOC1,,,,val
US20150315227A1,COC(C)(OC)N1CCOCC1.Nc1ccn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1>>CC(=Nc1ccn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1)N1CCOCC1,,CO,,O,c1ccncc1,val
US20090131458A1,BrCC1CCOCC1.CCC(C)COc1nc(N)c2nc(OC)[nH]c2n1>>CCC(C)COc1nc(N)c2nc(OC)n(CC3CCOCC3)c2n1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20020132796A1,CCOC1(c2ccc(C#C[Si](C)(C)C)cc2C(C)C)CC1>>C#Cc1ccc(C2(OCC)CC2)c(C(C)C)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20140336207A1,Nc1nc(C2CC2)ns1.O=C(Cl)Oc1ccccc1>>O=C(Nc1nc(C2CC2)ns1)Oc1ccccc1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20030092677A1,CS(=O)(=O)Cl.Nc1cccc(C2=Nc3ccc(-c4ccc(F)cc4)cc3NC(=O)C2)c1>>CS(=O)(=O)Nc1cccc(C2=Nc3ccc(-c4ccc(F)cc4)cc3NC(=O)C2)c1,,C1CCOC1,,CCN(CC)CC,,val
US20150290194A1,CCOC(=O)c1cnc2nc1NCCCCc1cn(nn1)CCCCCCN2>>O=C(O)c1cnc2nc1NCCCCc1cn(nn1)CCCCCCN2,,CO,,Cl,[K+].[OH-],val
US20070191413A1,CCOc1cc2c(cc1OC)C(c1ccc(-n3ccnc3)cc1)=NC1CCC(OC(C)=O)CC21>>CCOc1cc2c(cc1OC)C(c1ccc(-n3ccnc3)cc1)=NC1CCC(O)CC21,,CO,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100324030A1,O=c1[nH]c2cc(C3OCCCO3)ccc2o1>>O=Cc1ccc2oc(=O)[nH]c2c1,,CO,,Cl,,val
US05387684,CCCCc1nc(Cl)c(CO)n1Cc1ccc2nn(-c3ccccc3C(=O)OCC)c(Br)c2c1>>CCCCc1nc(Cl)c(CO)n1Cc1ccc2nn(-c3ccccc3C(=O)O)c(Br)c2c1,,O,,CCO,[K+].[OH-],val
US06090797,CN1CCC(C2=NCCc3ccsc32)CC1.COc1ccc(C(=O)Cl)cc1>>COc1ccc(C(=O)N2CCc3ccsc3C2C2CCN(C)CC2)cc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20130029971A1,BrC(Br)(Br)Br.CC(O)C1CCN(c2ncc(Cl)cc2NC(=O)c2cccc(Cl)c2)CC1>>O=C(Nc1cc(Cl)cnc1N1CCC(CBr)CC1)c1cccc(Cl)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070161651A1,NC(=O)c1ccccc1N.O=Cc1ccncc1>>O=c1[nH]c(-c2ccncc2)nc2ccccc12,,CO,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20090143439A1,BrC(Br)(Br)Br.CSc1cc(N)nc(CO)c1>>CSc1cc(N)nc(CBr)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040097563A1,COc1ccc(COc2ccccc2-c2cc(-c3ccc(N(C)C)c(NC(=O)CCl)c3)c(C#N)c(N)n2)cc1.NCC1CC1>>COc1ccc(COc2ccccc2-c2cc(-c3ccc(N(C)C)c(NC(=O)CNCC4CC4)c3)c(C#N)c(N)n2)cc1,,CN(C)C=O,,,,val
US20150284362A1,Fc1ccc2c(c1)c1cc(F)ccc1n2CC1CO1.NCCCN.O=C(n1ccnc1)n1ccnc1>>O=C1NCCCN1CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc21,CN(C)c1ccncc1,CCO,ClCCl,,,val
US20030060459A1,CC(C)(C)OC(=O)CN.O=C(O)c1cc([N+](=O)[O-])cc(C(F)(F)F)c1>>CC(C)(C)N(CC(=O)O)C(=O)c1cccc(C(F)(F)F)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20110218197A1,COc1nc(-c2ccccc2Cl)cc2nc(-c3c(Cl)c(C(C)(C)C)nn3C)[nH]c12.CS(=O)(=O)O>>COc1nc(-c2ccccc2Cl)cc2nc(-c3c(Cl)c(C(C)(C)C)nn3C)[nH]c12.CS(=O)(=O)O,,ClCCl,,,,val
US20130079323A1,CCOC(=O)Cn1c(=O)cc(Sc2nc(N3CC(O)C3)c3cc(CC)[nH]c3n2)[nH]c1=O.O=C1CCC(=O)N1Br>>CCOC(=O)Cn1c(=O)cc(Sc2nc(N3CC(O)C3)c3c(Br)c(CC)[nH]c3n2)[nH]c1=O,,C1CCOC1,,,,val
US05219860,c1ccc2c(c1)CCC21CCNCC1>>c1ccc2c(c1)CCC21CCNCC1,,O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20090029975A1,CS(=O)(=O)c1cc(CCC(=O)O)nc(-c2nc(=O)c3ccc(Cl)cc3s2)c1.NC(CO)(CO)CO>>CS(=O)(=O)c1cc(CCC(=O)O)nc(-c2nc(=O)c3ccc(Cl)cc3s2)c1.NC(CO)(CO)CO,,CC(C)=O,,,,val
US20090203697A1,C[C@@H](O)c1cc(F)c(F)c(F)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>C[C@H](N=[N+]=[N-])c1cc(F)c(F)c(F)c1,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,O,val
US20040072832A1,Cc1cc2c(F)c(Oc3ncnn4cc(O)c(C)c34)ccc2[nH]1.ClCC1CO1>>Cc1cc2c(F)c(Oc3ncnn4cc(OCC5CO5)c(C)c34)ccc2[nH]1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020107269A1,CNc1ccc(C)cc1N.O=C(Cl)c1cc([N+](=O)[O-])ccc1Cl>>Cc1ccc2c(c1)nc(-c1cc([N+](=O)[O-])ccc1Cl)n2C,,ClC(Cl)Cl,,CCN(CC)CC,,val
US06080743,CCOC(=O)CC1=CSC(N)N1Cc1cc([N+](=O)[O-])cc2[nH]c(=O)c(=O)[nH]c12.Cl>>Cl.NC1SC=C(CC(=O)O)N1Cc1cc([N+](=O)[O-])cc2[nH]c(=O)c(=O)[nH]c12,,[Na+],[OH-],Br,,val
US20030078251A1,CC(=O)Cl.COc1cccc([C@H]2O[C@H](CC(=O)NS(=O)(=O)CCCSc3ccccc3)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC>>COc1cccc([C@H]2O[C@H](CC(=O)NS(=O)(=O)CCCSc3ccccc3)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC,,O,,CCOC(C)=O,c1ccncc1,val
US05109012,CSCS(C)=O.O=Cc1cnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)n1>>CSC(=Cc1cnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)n1)S(C)=O,,C1CCOC1,CO,,,val
US20130116245A1,CC(=O)Cl.OCc1c(Br)cc(F)cc1Br>>CC(=O)OCc1c(Br)cc(F)cc1Br,,ClCCl,,c1ccncc1,,val
US20110144334A1,Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)Cl.Nc1ccc(Cl)cn1>>Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)Nc1ccc(Cl)cn1,,c1ccncc1,,,,val
US04470988,O=C1CCCC(=O)c2ccccc2N1>>O=C1CCCC(O)c2ccccc2N1,,CCO,,[BH4-].[Na+],,val
US05574178,CC(=O)Oc1c(C(C)(C)C)cc(OC2CCCCO2)c(C)c1C(C)(C)C>>CC(=O)Oc1c(C(C)(C)C)cc(O)c(C)c1C(C)(C)C,,C1CCOC1,,Cl,O,val
US20120190654A1,COc1ccc(CN2Cc3c(Oc4ccc5c(N)nn(C)c5c4)ccnc3NC2=O)cc1.O=C(O)c1cccc(F)c1>>COc1ccc(CN2Cc3c(Oc4ccc5c(NC(=O)c6cccc(F)c6)nn(C)c5c4)ccnc3NC2=O)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20150299192A1,C=C(C)OC.CN(Cc1ccc([N+](=O)[O-])cc1C(F)(F)F)CC(O)CO>>CN(Cc1ccc([N+](=O)[O-])cc1C(F)(F)F)CC1COC(C)(C)O1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20050096389A1,C1CCOC1.CC(C)CC(CO)(CO)CC(C)C.O=C(Cl)c1ccccc1.c1ccncc1>>CC(C)CC(COC(=O)c1ccccc1)(COC(=O)c1ccccc1)CC(C)C,,O,,,,val
US20070117824A1,CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(Cl)nc1.CCNC(=O)N1CCCC12CCNCC2>>CCNC(=O)N1CCCC12CCN(c1ccc(C(=O)Nc3cc(-c4cccs4)ccc3N)cn1)CC2,,CS(C)=O,,CCN(CC)CC,,val
US05756507,CC(=O)O.CNC.Cc1cc(C)cc(-c2cc3ccccc3[nH]2)c1>>Cc1cc(C)cc(-c2[nH]c3ccccc3c2CN(C)C)c1,,CCO,,,,val
US20040254215A1,CC(=O)OCCBr.O=C1NC(=O)c2c(Br)cccc21>>CCOC(=O)CN1C(=O)c2ccc(Br)cc2C1=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05846989,Cc1ccc(CCO)s1.O=C(O)CCl>>Cc1ccc(CCOCC(=O)O)s1,,CN(C)C=O,,[H-].[Na+],,val
US20150166521A1,CCOC(=O)CS(C)(=O)=NC(=O)OC(C)(C)C>>CCOC(=O)CS(C)(=N)=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090275558A1,C1CCNC1.CC(C)(C)OC(=O)N1CCc2sc(COS(C)(=O)=O)cc2C1>>CC(C)(C)OC(=O)N1CCc2sc(CN3CCCC3)cc2C1,,CCOC(C)=O,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20130109856A1,CC(=CC(=O)NC(C)(C)C)OC(=O)c1nc(Cl)c(NCC2CC2)nc1N.CSC(=N)N>>CSC(=N)NC(=O)c1nc(Cl)c(NCC2CC2)nc1N,,C1CCOC1,,O=S(=O)(O)O,[Na+].[OH-],val
US20160272624A1,O=CN1CCN(c2cccc3sc(C(=O)O)cc23)CC1>>O=CN1CCN(c2cccc3sccc23)CC1,,c1ccc2ncccc2c1,,,,val
US04670434,C=c1c(=O)[nH]c2n1Cc1cc(OCCCC(=O)N(C)C3CCCCC3)ccc1N=2.Cl>>C=c1c(=O)[nH]c2n1Cc1cc(OCCCC(=O)N(C)C3CCCCC3)ccc1N=2.Cl,,CO,,CCOCC,,val
US20110105535A1,CC(=O)C(Br)c1ccnc(C(C)(C)C)n1.NC(N)=S>>Cc1nc(N)sc1-c1ccnc(C(C)(C)C)n1,,CCO,,,,val
US20150196672A1,CC(C)(C)n1ncc(Cl)c(Cl)c1=O.CC(C)(O)c1ccc(CO)cc1>>CC(C)(O)c1ccc(COc2cnn(C(C)(C)C)c(=O)c2Cl)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070129355A1,COC(=O)Cc1cnc(Cc2ccc(N)cc2)nc1N(C)C.O=C(Cl)OCc1ccccc1>>COC(=O)Cc1cnc(Cc2ccc(NC(=O)OCc3ccccc3)cc2)nc1N(C)C,,ClCCl,c1ccncc1,,,val
US06130228,N#CC1=C(Nc2cc(F)cc(F)c2)CCC1>>Nc1c2c(nc3cc(F)cc(F)c13)CCC2,Cl[Ti](Cl)(Cl)Cl,[Na+],[OH-],,,val
US20150361059A1,Nc1ccc(F)c(F)c1OC1(C(C(=O)O)N(Cc2ccccc2)Cc2ccccc2)CCOCC1>>O=C1Nc2ccc(F)c(F)c2OC2(CCOCC2)C1N(Cc1ccccc1)Cc1ccccc1,,CN(C)C=O,O,CCN=C=NCCCN(C)C,,val
US20030109523A1,COC(=O)CC1CCc2cc(OCCCNc3ncccn3)ccc2C1>>O=C(O)CC1CCc2cc(OCCCNC3=NCCCN3)ccc2C1,[Pd],CC(=O)O,,Cl,,val
US05864039,COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCCN)CC1.Cn1cc(C(=O)O)c2ccccc21>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCCNC(=O)c2cn(C)c3ccccc23)CC1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US04992449,CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)cc21.N[C@@H]1CCCC[C@H]1N>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N[C@@H]3CCCC[C@H]3N)cc21,,c1ccncc1,,,,val
US20130116216A1,CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)CC1>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(N)cc2)CC1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20060211678A1,CC(C)(C)OC(=O)N1CC=C(c2cc3c(Cl)ncnc3[nH]2)CC1.Nc1cccc(-c2ccccc2)c1>>CC(C)(C)OC(=O)N1CC=C(c2cc3c(Nc4cccc(-c5ccccc5)c4)ncnc3[nH]2)CC1,,CCCCO,,,,val
US20120264737A1,CCc1cc(C2CCC2)ccc1C(=O)OC.II>>CCc1cc(C2CCC2)c(I)cc1C(=O)OC,,CC(=O)O,,O=S(=O)(O)O,,val
US20140162985A1,CCC12CCC3(CC1CCCc1cc(N=C(c4ccccc4)c4ccccc4)ccc12)OCCO3>>CCC12CCC3(CC1CCCc1cc(N)ccc12)OCCO3,[Pd],CO,,O=C[O-].[NH4+],,val
US20090088459A1,CC(C)CNS(=O)(=O)c1ccccc1Cl.ClCc1cncc(Br)c1>>CC(C)CN(Cc1cncc(Br)c1)S(=O)(=O)c1ccccc1Cl,,CC(=O)N(C)C,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20140371199A1,CC(C)(C)OC(=O)NC1CCNCC1.N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)O)cc4)nn23)cc1>>N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)N5CCC(N)CC5)cc4)nn23)cc1,,CN(C)C=O,O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05519007,CC(=O)NCC(=O)O.CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO>>CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)NC(=O)CNC(C)=O,,ClC(Cl)Cl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20050261291A1,CC1(C)C=C(c2ccccc2N)CC1(C)C.ClCCNCCCl>>CC1(C)C=C(c2ccccc2N2CCNCC2)CC1(C)C,,Clc1ccccc1Cl,,Cl,,val
US20090015143A1,NCCN.O=C(C(=O)c1ccc(F)cc1)c1ccc(F)cc1>>Fc1ccc(C2=NCCN=C2c2ccc(F)cc2)cc1,,CCO,,,,val
US04910190,CCOC(=O)CCCBr.NC(=O)Cc1ccc(O)cc1>>CCOC(=O)CCCOc1ccc(C(N)=O)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100310512A1,CCOC(=O)C1CCC(CN(CC(=O)OC(C)(C)C)C(=O)OC)N1C(=O)OC(C)(C)C>>CCOC(=O)C1CCC(CN(CC(=O)O)C(=O)OC)N1,,C1COCCO1,,Cl,,val
US20090005364A1,O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCNCC1.O=Cc1ccc(Cl)cc1>>O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccc(Cl)cc2)CC1,,CO,,[BH3-]C#N.[Na+],,val
US05166403,COC(=O)c1ccc(CN(C)C(=O)OC(C)(C)C)cc1.Cl>>CNCc1ccc(C(=O)OC)cc1.Cl,,CCOC(C)=O,,,,val
US20160272645A1,C=CC(=O)N(CCn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21)Cc1ccccc1F.CS(=O)(=O)O>>C=CC(=O)N(CCn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21)Cc1ccccc1F.CS(=O)(=O)O,,C1CCOC1,,,,val
US20110124873A1,Brc1ccccc1.C=CC(=O)OCCCC>>CCCCOC(=O)/C=C/c1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060111336A1,COc1ccc(C(=O)N(C)c2ccc([C@H](C(=O)N(C)C)[C@H](NC(=O)OC(C)(C)C)C(=O)N3CC[C@H](F)C3)cc2)cc1.O=C(O)C(F)(F)F>>COc1ccc(C(=O)N(C)c2ccc([C@H](C(=O)N(C)C)[C@H](N)C(=O)N3CC[C@H](F)C3)cc2)cc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20130158006A1,COC(=O)CBr.COc1ccc(O)c(C=O)c1>>COC(=O)c1cc2cc(OC)ccc2o1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120184509A1,C=C[Si](C)(C)c1ccc(NC(=O)OC(C)(C)C)cc1>>C=C[Si](C)(C)c1ccc(N)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080242596A1,C#CCCOCc1cc(Cl)c(Cc2ccc(CC)cc2)cc1Br.C[Si](C)(C)Cl>>CCc1ccc(Cc2cc(Br)c(COCCC#C[Si](C)(C)C)cc2Cl)cc1,,O,,CC(C)[N-]C(C)C.[Li+],,val
US20060025347A1,CCOC(=O)CCc1oc2ccccc2c1CC1CCCN1C(=O)C(CCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NC(CCCNC(=O)OCc1ccccc1)C(=O)N1CCCC1Cc1c(CCC(=O)O)oc2ccccc12,,C1CCOC1,,[Na+].[OH-],,val
US20090099369A1,ClCCl.O=C(NO)c1ccc(CO)cc1O>>Oc1noc2cc(CCl)ccc12,,ClCCl,,CN(C)C=O,O=S(Cl)Cl,val
US20120165320A1,N#CC1(c2ccc(Br)cc2)CC1CO>>NCC1(c2ccc(Br)cc2)CC1CO,,C1CCOC1,,CCOCC,FB(F)F,val
US04268676,C=C(Cl)CN.COC1=C(C)C(=O)C2=C(C1=O)[C@@H](COC(N)=O)[C@@]1(OC)[C@@H]3[C@H](CN21)N3C>>C=C(Cl)CNC1=C(C)C(=O)C2=C(C1=O)C(CO)C1(OC)C3C(CN21)N3C.NC(=O)O,,CO,,,,val
US20100240620A1,COc1cc(C#N)ccc1C=C(C(C)=O)c1nc(C)cs1.N#CC=C(N)C(F)(F)F>>COc1cc(C#N)ccc1C1C(C#N)=C(C(F)(F)F)NC(C)=C1c1nc(C)cs1,,CC(C)O,,CC(C)(C)[O-].[K+],,val
US05102881,O=C(O)CS.c1ccc(COCC(OCc2ccccc2)c2ccc(OCc3ccc4ccccc4n3)cc2)cc1>>O=C(O)CSC(COCc1ccccc1)c1ccc(OCc2ccc3ccccc3n2)cc1,,ClCCl,,CCOCC,FB(F)F,val
US20020002158A1,CC(=O)CCC(C)=O.Nc1ccc(Br)cc1>>Cc1ccc(C)n1-c1ccc(Br)cc1,,Cc1ccccc1,,CC(=O)O,,val
US20080009530A1,CC(=O)C(C)(C)C.CCOC(=O)C(=O)OCC.NN>>CCOC(=O)c1cc(C(C)(C)C)n[nH]1,,C1CCOC1,CC(=O)O,O,CC(C)(C)[O-].[K+],val
US20130079306A1,CCOC(=O)C(Cl)C(C)=O.COc1cc(Cl)ccc1C(N)=S>>CCOC(=O)c1sc(-c2ccc(Cl)cc2OC)nc1C,,CCO,,,,val
US20140135318A1,CCCCN(CCCC)C(=O)c1cn(CC(=O)O)c(-c2ccc(C(=O)OC)cc2C(=O)N2CCc3ccccc3C2)n1.CN>>CCCCN(CCCC)C(=O)c1cn(CC(=O)NC)c(-c2ccc(C(=O)OC)cc2C(=O)N2CCc3ccccc3C2)n1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06306891B1,C=O.CC(=O)c1cc(NCc2ccccc2)cn1Cc1ccc(F)cc1>>CC(=O)c1cc(NCCc2ccccc2)cn1Cc1ccc(F)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20040162287A1,CN(C)C1(Cc2ccccc2)CCC(=O)CC1.NCc1c[nH]c2ccccc12>>CN(C)C1(Cc2ccccc2)CCC(NCc2c[nH]c3ccccc23)CC1,,ClCCCl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130224107A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100056532A1,CCOC(=O)c1c(C2CCCCC2)csc1NC(=O)Nc1ccc(F)c(F)c1>>O=C(Nc1ccc(F)c(F)c1)Nc1scc(C2CCCCC2)c1C(=O)O,,CCO,,[Na+].[OH-],,val
US20030004161A1,Cc1cc(N)n[nH]1.Clc1cc(-c2ccccc2)nc(Cl)n1>>Cc1cc(Nc2cc(-c3ccccc3)nc(Cl)n2)[nH]n1,,CN(C)C=O,,CCN(CC)CC,[I-].[Na+],val
US05444050,COB(OC)OC.Oc1ccccc1Br>>OB(O)c1ccccc1O,,C1CCOC1,,Cl,,val
US20160122318A1,CC(C)(C)OC(=O)NCC1CCN(S(C)(=O)=O)CC1.Cl>>CS(=O)(=O)N1CCC(CN)CC1.Cl,,C1COCCO1,,,,val
US20070213341A1,C=C(N=Cc1cc(F)ccc1C)O[Si](C)(C)C.O=C1Nc2cc(Br)ccc2/C1=C/c1cccc(Cl)c1>>Cc1ccc(F)cc1C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Br)ccc12,,Cc1ccccc1,,,,val
US04705795,CC1CNCC(C)C1.N#CCCCCl>>CC1CC(C)CN(CCCC#N)C1,,c1ccccc1,,,,val
US20040192729A1,NC(=S)N1CCN(Cc2ccccc2)CC1.O=C(O)C(=O)CBr>>Br.O=C(O)c1csc(N2CCN(Cc3ccccc3)CC2)n1,,CCO,,,,val
US20080009530A1,COCCCOc1ccc(/C=C/C(=O)O)c(Oc2ncc(C(F)(F)F)cc2Cl)c1>>COCCCOc1ccc(CCC(=O)O)c(Oc2ncc(C(F)(F)F)cc2Cl)c1,,C1CCOC1,,,,val
US20040248897A1,CCC(=O)CC(=O)CC.Cc1cc(I)ccc1NN>>CCc1cc(CC)n(-c2ccc(I)cc2C)n1,,CO,,CCN(CC)CC,,val
US04588433,COC(=O)c1ccccc1S.ClCOc1ccc(Cl)cc1Cl>>COC(=O)c1ccccc1SCOc1ccc(Cl)cc1Cl,,C1CCOC1,CN(C)C=O,,,val
US04186129,COc1ccc(C(O)C(C)N)cc1OC.O=C(c1ncc[nH]1)c1ncc[nH]1>>COc1ccc(C2OC(=O)NC2C)cc1OC,,ClC(Cl)Cl,,,,val
US20040122016A1,O=C(CSc1ccccc1)Nc1nc(-c2ccncc2)cs1.O=C(OO)c1cccc(Cl)c1>>O=C(CS(=O)c1ccccc1)Nc1nc(-c2ccncc2)cs1,,CN(C)C=O,O,,,val
US20080188566A1,Cc1cc(C[C@H](CCCC=O)C(=O)N2C(=O)OC[C@H]2Cc2ccccc2)cc(C)c1F.NCc1ccc(F)cc1>>Cc1cc(C[C@H](CCCCNCc2ccc(F)cc2)C(=O)N2C(=O)OC[C@H]2Cc2ccccc2)cc(C)c1F,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04426388,COc1ccc2sc(S(N)(=O)=O)nc2c1>>NS(=O)(=O)c1nc2cc(O)ccc2s1,,CCCCCCC,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20150336962A1,CO.NCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1.O=Cc1cccc(O)c1>>O=C(Nc1cn(CCNCc2cccc(O)c2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12.O=CO,,CO,,[BH3-]C#N.[Na+],,val
US20050143443A1,CCOC(=O)c1[nH]ccc1C.O=C(Cl)Cc1ccc(Cl)cc1>>CCOC(=O)c1[nH]cc(C(=O)Cc2ccc(Cl)cc2)c1C,,ClCCCl,ClCCl,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20110281903A1,CC1NCC2(CCN(C)CC2)S1.CCCC(CCC)C(=O)Cl>>CCCC(CCC)C(=O)N1CC2(CCN(C)CC2)SC1C,,ClCCl,,CCN(CC)CC,,val
US20060025438A1,C=C[Mg]Br.O=CCCCc1ccccc1>>C=CC(O)CCCc1ccccc1,,C1CCOC1,,,,val
US20130053382A1,CCCCOC(=O)N1Cc2ccc(-c3cc4cnn(COCC[Si](C)(C)C)c4cc3[N+](=O)[O-])cc2C1.CCOC(C)=O>>CC(C)(C)OC(=O)N1Cc2ccc(-c3cc4cnn(COCC[Si](C)(C)C)c4cc3N)cc2C1,[Pd],CCOC(C)=O,,,,val
US20110070317A1,CCOC(=O)C1(C)CCCN(C(=O)OCc2ccccc2)C1>>CC1(C(=O)O)CCCN(C(=O)OCc2ccccc2)C1,,CCO,,[Li+].[OH-],,val
US20100272681A1,CC(C)(C)OC(=O)[C@@H]1C[C@@]2(CN(c3ccccc3)C(=O)O2)CN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)(C)C>>CC(C)(C)OC(=O)[C@@H]1C[C@@]2(CN(c3ccccc3)C(=O)O2)CN1C(=O)[C@@H](N)C(C)(C)C,[Pd],CO,,,,val
US20010027196A1,N#Cc1c(Cl)nc(N)nc1-c1ccccc1.OCc1ccccc1>>N#Cc1c(OCc2ccccc2)nc(N)nc1-c1ccccc1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20160039834A1,COC(=O)N1CCC(N)CC1.Cc1noc(C)c1-c1nc(-c2cccc(OCC(CN(C)C(=O)OC(C)(C)C)O[Si](C)(C)C(C)(C)C)c2)nc(Cl)c1C>>COC(=O)N1CCC(Nc2nc(-c3cccc(OCC(CN(C)C(=O)OC(C)(C)C)O[Si](C)(C)C(C)(C)C)c3)nc(-c3c(C)noc3C)c2C)CC1,,CCOC(C)=O,CS(C)=O,CCN(CC)CC,Cl,val
US20100185419A1,CC(C)(C)OC(=O)Nc1ccc(S)cc1.CS(=O)(=O)c1nc(Cl)cc(Cl)n1>>CC(C)(C)OC(=O)Nc1ccc(Sc2nc(Cl)cc(Cl)n2)cc1,,CC(C)(C)O,,CC(=O)[O-].[Na+],,val
US20080261965A1,CC(=O)O.Ic1ccccc1.O=[N+]([O-])c1ccc(S(=O)(=O)O)c([N+](=O)[O-])c1>>O=[N+]([O-])c1ccc(S(=O)(=O)OI(O)c2ccccc2)c([N+](=O)[O-])c1,,CC#N,,CC(=O)O,,val
US20140274933A1,Cc1nc2ccc(N(C)C(=O)C(F)(F)F)cc2o1>>CNc1ccc2nc(C)oc2c1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20110212937A1,CN.FC(F)(F)Oc1ccc(C2COCc3c(Cl)nc(Cl)nc32)cc1>>CNc1nc(Cl)nc2c1COCC2c1ccc(OC(F)(F)F)cc1,,CO,,,,val
US20030144288A1,COc1ccc(C2CCCCC2)c2sc(N)nc12.O=C(Cl)c1ccc(CCl)cc1>>COc1ccc(C2CCCCC2)c2sc(NC(=O)c3ccc(CCl)cc3)nc12,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,,val
US20130131034A1,CS(=O)(=O)c1ccc2c(c1)C(O)CC2>>CS(=O)(=O)c1ccc2c(c1)C=CC2,,Cc1ccccc1,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080045550A1,CC(C)(C)OC(=O)N1CCC(N)CC1.COc1cc2nc(Cl)nc(Cl)c2cc1OC>>COc1cc2nc(Cl)nc(NC3CCN(C(=O)OC(C)(C)C)CC3)c2cc1OC,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US04686224,CC(=O)c1cccc2cc[nH]c12.O=C1CCC(=O)N1Cl>>CC(=O)c1cccc2c1NC(=O)C2,,ClCCl,,,,val
US20080090834A1,O=C(Cc1cccnc1)c1ccc(-n2ccc3cccnc32)cc1.O=N[O-]>>O=C(C(=NO)c1cccnc1)c1ccc(-n2ccc3cccnc32)cc1,,O,,CC(=O)O,,val
US20060025438A1,C#CC(O)CCCc1ccc(OC)cc1.O=C1NC(=O)c2ccccc21>>C#CC(CCCc1ccc(OC)cc1)N1C(=O)c2ccccc2C1=O,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060058553A1,CCOC(=O)c1ccc(-c2cccc(CO)c2)cc1.Oc1cccnc1>>CCOC(=O)c1ccc(-c2cccc(COc3cccnc3)c2)cc1,,C1CCOC1,CCOC(C)=O,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060264460A1,N#Cc1cnc2c(I)cc([N+](=O)[O-])cc2c1Cl.Nc1ccc(F)c(Cl)c1>>N#Cc1cnc2c(I)cc([N+](=O)[O-])cc2c1Nc1ccc(F)c(Cl)c1,,CCO,,,,val
US20110015202A1,CCOC(=O)Cn1ccc(-n2cc(C#Cc3cccc(C)c3)nc2C)cc1=O.N>>Cc1cccc(C#Cc2cn(-c3ccn(CC(N)=O)c(=O)c3)c(C)n2)c1,,CO,,,,val
US05232917,CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.CC(Br)C(=O)Cl.CN(C)c1ccccn1.ClCCl.O>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](OC(=O)C(C)NCCO)CC[C@]4(C)[C@H]3CC[C@]12C.Cl,,ClCCl,,CCN(CC)CC,,val
US20150010504A1,Brc1ccc2c(c1)CCc1sc(Br)nc1-2.C1COCCO1.C=C(OCC)[Sn](CCCC)(CCCC)CCCC>>CC(=O)c1ccc2c(c1)CCc1sc(C(C)=O)nc1-2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,[F-].[K+],,val
US20110230521A1,CC[Mg]Br.O=Cc1cnc(Br)s1>>CCC(O)c1cnc(Br)s1,,C1CCOC1,CCOC(C)=O,[Cl-].[NH4+],,val
US20100113438A1,CC(=O)N1[C@@H](C)CN(C(=O)OC(C)(C)C)C[C@H]1C.Cl>>CC(=O)N1[C@@H](C)CNC[C@H]1C.Cl,,ClCCl,,CCOCC,,val
US05755994,CCCOCc1ccc(C(=O)O)cc1.O=S(Cl)Cl>>CCCOCc1ccc(C(=O)Cl)cc1,,Cc1ccccc1,,c1ccncc1,,val
US04533739,CC(=O)Nc1ccc(N)c(C)c1.ClC1=NCCC1>>CC(=O)Nc1ccc(NC2=NCCC2)c(C)c1,,Cc1ccccc1,,,,val
US20100035898A1,CC1CC(CNc2ccccc2)CCC1NCc1ccccc1>>CC1CC(CNc2ccccc2)CCC1N,[Pd],CCO,,O=C[O-].[NH4+],,val
US07763657B2,ClI.N#Cc1ccc(N)c(Cl)c1>>N#Cc1cc(Cl)c(N)c(I)c1,,ClCCl,,,,val
US20070155839A1,CC(C)(C)OC(=O)/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2)c(F)c1>>O=C(O)/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2)c(F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04672068,CC(C)(C)O.CC=CC=CCOC(=O)C1=C(C)NC(C)=C(C(=O)O)C1c1cccc([N+](=O)[O-])c1>>CC=CC=CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1cccc([N+](=O)[O-])c1,CN(C)c1ccncc1,CC(Cl)Cl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100137278A1,COC(=O)C1(c2nccnc2Oc2ccc(N(C(=O)OC(C)(C)C)c3nc4ccccc4s3)cc2)CCN(C(=O)OC(C)(C)C)CC1>>CC(C)(C)OC(=O)N1CCC(CO)(c2nccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110021351A1,O=C(CC(=NO)C(F)(F)F)c1c(O)c2nccnc2[nH]c1=O>>O=c1[nH]c2nccnc2c(O)c1-c1cc(C(F)(F)F)no1,,O=C(O)C(F)(F)F,,,,val
US20080153812A1,COC(=O)c1cnc(Cl)nc1.COCC1CNCCN1>>COCC1CN(c2ncc(C(=O)OC)cn2)CCN1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080032968A1,COC(OC)N(C)C.Cc1c(Br)cc(F)cc1[N+](=O)[O-]>>Fc1cc(Br)c2cc[nH]c2c1,,CN(C)C=O,ClCCl,,,val
US20150005289A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.O=c1cc(O)nc2cnc(Br)cn12>>CC(C)(C)OC(=O)N1CC=C(c2cn3c(=O)cc(O)nc3cn2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100105657A1,O=[N+]([O-])c1ccc2c(c1)CN(CCF)CCO2>>Nc1ccc2c(c1)CN(CCF)CCO2,[Pd],CCOC(C)=O,CO,[H][H],,val
US03931199,CC(=O)c1ccc(O)cc1.O=C(O)c1cccnc1Cl>>CC(=O)c1ccc(Oc2ncccc2C(=O)O)cc1,,CO,,[Na],,val
US20110245241A1,CC1(C)OCCn2c1nc(C(=O)NN)c(OCc1ccccc1)c2=O.O=C(Cl)Cc1ccc(F)cc1>>CC1(C)OCCn2c1nc(C(=O)NNC(=O)Cc1ccc(F)cc1)c(OCc1ccccc1)c2=O,,ClCCl,,CCN(CC)CC,,val
US20100317625A1,COc1cc2ccsc2cc1OC>>Oc1cc2ccsc2cc1O,,CCCCCC,CCOCC,,,val
US20150175561A1,CC(C)(C)OC(=O)NC(CC(=O)OCc1ccccc1)c1nnn[nH]1.N>>CC(C)(C)OC(=O)NC(CC(N)=O)c1nnn[nH]1,,CO,,,,val
US20030073846A1,CC(C)(C)OC(=O)N[C@H](CO)Cc1ccc(O)c(Cl)c1.COC(C)(C)OC>>CC(C)(C)OC(=O)N1[C@@H](Cc2ccc(O)c(Cl)c2)COC1(C)C,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20030229079A1,C[Si](C)(C)CCOCn1ccnc1C(=O)CC(=O)c1cc(Cn2cccn2)cc(Cn2cccn2)c1>>O=C(CC(=O)c1ncc[nH]1)c1cc(Cn2cccn2)cc(Cn2cccn2)c1,,CC(=O)O,O,,,val
US20070167443A1,BrCc1cccc(Br)n1.Cc1ccc(C(=O)c2c[nH]c3ccccc3c2=O)nc1C>>Cc1ccc(C(=O)c2cn(Cc3cccc(Br)n3)c3ccccc3c2=O)nc1C,,CN(C)C=O,,[H-].[Na+],,val
US20040186077A1,CC(C)(C)OP(=O)(OC(C)(C)C)C(O)c1cnc2ccccc2c1.CCN(CC)S(F)(F)F>>CC(C)(C)OP(=O)(OC(C)(C)C)C(F)c1cnc2ccccc2c1,,ClCCl,,O=C([O-])O.[Na+],,val
US05424443,O=[N+]([O-])c1c(F)cc(Cl)c2nc(Cl)sc12>>Nc1c(F)cc(Cl)c2nc(Cl)sc12,[Fe],CC(=O)O,CCOC(C)=O,,,val
US04610983,NC(CCC(=O)O)C(=O)O.O=C(Cl)C=Cc1ccco1>>O=C(O)CC[C@H](NC(=O)C=Cc1ccco1)C(=O)O,,CCOCC,O,[Na+].[OH-],,val
US20150232463A1,Cc1nc(C)c(C(=O)C(=O)OC(C)C)c(Cl)c1Br.c1ccc(C2CCNCC2)cc1>>Cc1nc(C)c(C(=O)C(=O)OC(C)C)c(N2CCC(c3ccccc3)CC2)c1Br,,CC#N,,CCN(C(C)C)C(C)C,,val
US04355040,CCCCOc1ccc(-c2nc(Cl)c(CC(=O)O)n2Cc2ccccc2)cc1>>O=C(O)Cc1c(Cl)nc(-c2ccc(O)cc2)n1Cc1ccccc1,,Br,,O,,val
US04625032,CC(=O)OC(C)=O.CSC(=S)N1Cc2[nH]c3ccccc3c2C[C@H]1CO>>CSC(=S)N1Cc2[nH]c3ccccc3c2C[C@H]1COC(C)=O,,c1ccncc1,,Cl,,val
US20100029689A1,CC(C)COS(=O)(=O)c1ccc(N(Cc2cncs2)c2ccc(OC(F)F)c(OC(F)F)c2)cc1>>O=S(=O)(O)c1ccc(N(Cc2cncs2)c2ccc(OC(F)F)c(OC(F)F)c2)cc1,,CC(C)=O,,[I-].[Na+],,val
US20060089375A1,CCOC(=O)c1cnc2c(cnn2CC)c1N[C@H]1CCOC1>>CCn1ncc2c(N[C@H]3CCOC3)c(C(=O)O)cnc21,,CCO,O,[Na+].[OH-],,val
US20080056987A1,CCOC=C(C(=O)OCC)C(=O)OCC.Nc1ccc2c(c1)CCS2(=O)=O>>CCOC(=O)C(=CNc1ccc2c(c1)CCS2(=O)=O)C(=O)OCC,,CCOC(C)=O,,,,val
US20130065877A1,CC1CCCN1C1CC[C@H](c2ccc(N)cc2)C1.COC(=O)C1(CC=O)CCC(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC1>>CC1CCCN1C1CCC(c2ccc(N3CCC4(CCC(O)CC4)C3=O)cc2)C1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20120232056A1,COC(=O)c1cc([N+](=O)[O-])c(F)cc1F.COc1ccc(CN)cc1>>COC(=O)c1cc([N+](=O)[O-])c(NCc2ccc(OC)cc2)cc1F,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20160102096A1,COc1ccc(Br)c(C)n1.OCc1ccccc1>>COc1ccc(OCc2ccccc2)c(C)n1,[Cu]I,Cc1ccccc1,,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US05663162,CC(C)(C)OC(=O)NCC(N)=S.CCOC(=O)C(=O)CBr>>CCOC(=O)c1csc(CNC(=O)OC(C)(C)C)n1,,CCO,,O=C([O-])[O-].[Ca+2],,val
US20110118245A1,CC(C)(C)c1cc(N=C=O)no1.Nc1ccc(F)c(O)c1>>CC(C)(C)c1cc(NC(=O)Nc2ccc(F)c(O)c2)no1,,Cc1ccccc1,,,,val
US20050075342A1,CCOC(=O)CCCCCC(=O)Cl.C[Si](C)(C)c1nccs1.ClCCl>>CCOC(=O)CCCCCC(=O)c1ccccc1,,ClCCl,,,,val
US20080300242A1,CCOc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)c(CC)cc1N.COc1ccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)cc1C(=O)Nc1c(F)cccc1F>>CCOc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)c(CC)cc1Nc1nccc(-c2c(-c3ccc(OC)c(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1,,OCC(F)(F)F,,Cl,,val
US20050277670A1,Brc1ccccn1.CC(C)(C)OC(=O)N1CCC(C=O)CC1>>CC(C)(C)OC(=O)N1CCC(C(O)c2cccnc2Br)CC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20080275097A1,Cc1ccnc(Cl)c1Oc1cc(Cl)cc(Br)c1.NN>>Cc1ccnc(NN)c1Oc1cc(Cl)cc(Br)c1,,CS(C)=O,,O,,val
US20070179165A1,COS(=O)(=O)OC.CSc1ncc(Br)c(=O)[nH]1>>CSc1ncc(Br)c(=O)n1C,,C1CCOC1,CCOC(C)=O,[K+].[OH-],,val
US04072696,C=CCS(=O)c1ccc(N)c([N+](=O)[O-])c1>>C=CCS(=O)c1ccc(N)c(N)c1,[Fe],O,,CO,,val
US20090022686A1,CCOC(=O)CI.Cn1c(CNc2ccc(C#N)cc2)nc2cc([C@@](C)(N)C(=O)N3CCCC3)ccc21>>CCOC(=O)CN[C@@](C)(C(=O)N1CCCC1)c1ccc2c(c1)nc(CNc1ccc(C#N)cc1)n2C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160207887A1,CCOC(=O)C1C2Cc3cc(N)ncc3C21.O=S(=O)(O)O>>CCOC(=O)C1C2Cc3cc(O)ncc3C21,,O=S(=O)(O)O,,O=N[O-].[Na+],,val
US20100056521A1,CC(=O)Cl.CCOC(=O)c1ccc(-n2cc(C#N)c3ccc(OCCN)cc32)cc1OCOC>>CCOC(=O)c1ccc(-n2cc(C#N)c3ccc(OCCNC(C)=O)cc32)cc1OCOC,,ClCCl,,CCN(CC)CC,,val
US20150361067A1,COc1cc(C)nc(OCc2ccccc2)c1CCl.Cc1cc(I)c(Cl)c2c1CCNC2=O>>COc1cc(C)nc(OCc2ccccc2)c1CN1CCc2c(C)cc(I)c(Cl)c2C1=O,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US04493728,C=O.CN.CN(C)C=O.CNC(=O)Nc1cc(C(C)(C)COC)on1>>COCC(C)(C)c1cc(N2CN(C)CN(C)C2=O)no1,,O,,,,val
US20080300242A1,CI.O=[N+]([O-])c1cc(Cl)c(F)cc1O>>COc1cc(F)c(Cl)cc1[N+](=O)[O-],,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110166162A1,COc1cc(CNS(=O)(=O)c2ccc(-c3ccc(F)cc3F)cc2C#N)ccn1>>COc1cc(CN2C(=N)c3cc(-c4ccc(F)cc4F)ccc3S2(=O)=O)ccn1,,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20110124637A1,Nc1ccc(F)cc1C(=O)O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(O)c1cc(F)ccc1NC(=O)C(F)(F)F,,C1CCOC1,,,,val
US20110288084A1,O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C1COc2ccc(CN[C@@H]3CC[C@@H](C(O)CNS(=O)(=O)c4ccccc4[N+](=O)[O-])CC3)nc2N1>>O=C1COc2ccc(CN(C(=O)C(F)(F)F)[C@@H]3CC[C@@H](C(O)CNS(=O)(=O)c4ccccc4[N+](=O)[O-])CC3)nc2N1,,C1CCOC1,,CCN(CC)CC,,val
US20090099156A1,CCN1CCCC(C=C2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1>>CCN1CCCC(CC2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1,[Pd],CCO,,,,val
US20090215786A1,CCOC(=O)CON=C1c2ccccc2-c2nc(C(N)=O)c(C#N)nc21>>N#Cc1nc2c(nc1C(N)=O)-c1ccccc1C2=NOCC(=O)O,,C1CCOC1,O,Cl,[Li]O,val
US03982007,NNC(N)=S.O=CC(=Cc1ccc([N+](=O)[O-])o1)c1ccc(Br)cc1>>NC(=S)NN=CC(=Cc1ccc([N+](=O)[O-])o1)c1ccc(Br)cc1,,CO,,CC(=O)O,CC(=O)[O-].[Na+],val
US20120202785A1,C[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccc(F)cc1NC1CN(C(=O)OC(C)(C)C)C1>>C[C@H](NC(=O)OCc1ccccc1)c1nc2ccc(F)cc2n1C1CN(C(=O)OC(C)(C)C)C1,,CC(=O)O,,,,val
US06420427B1,CC(C)(C)OC(=O)CBr.COC(=O)C(O)CCNC(=O)c1ccc(Cl)cc1>>COC(=O)C(CCNC(=O)c1ccc(Cl)cc1)OCC(=O)OC(C)(C)C,,C1CCOC1,,Cl,[H-].[Na+],val
US20060257987A1,CC(=O)Cl.CC(O)CCO>>CC(=O)OCCC(C)O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090023702A1,C=C(C)B(O)O.CS(=O)(=O)c1ccc(-n2ccc(OC3CCN(c4ncc(Br)cn4)CC3)cc2=O)cc1>>C=C(C)c1cnc(N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)cc4)c(=O)c3)CC2)nc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US06030967,Brc1ccc2c(c1)OCO2.COc1ccc(Br)c(C=O)c1>>COc1ccc(Br)c(C(O)c2ccc3c(c2)OCO3)c1,,C1CCOC1,,[Cl-].[NH4+],,val
US20050009895A1,Cc1nc(-c2ccc(CN3C(=O)c4ccccc4C3=O)c([N+](=O)[O-])c2)no1>>Cc1nc(-c2ccc(CN)c([N+](=O)[O-])c2)no1,,CCO,,NN,O,val
US20110257165A1,O=[N+]([O-])c1cccc(-c2nn3c(c2-c2ccncc2)SCC3O)c1>>O=[N+]([O-])c1cccc(-c2nn3ccsc3c2-c2ccncc2)c1,,CCOC(C)=O,COCCOC,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20160068545A1,C=CC[C@H](O)[C@@H]1CC[C@H]1CN1C[C@@]2(CCCc3cc(Cl)ccc32)COc2ccc(C(=O)OC)cc21>>C=CC[C@H](O)[C@@H]1CC[C@H]1CN1C[C@@]2(CCCc3cc(Cl)ccc32)COc2ccc(C(=O)O)cc21,,C1CCOC1,CO,Cl,[Li+].[OH-],val
US05010195,CSc1nc(F)cc(NN)n1.ClCc1ccccc1.S=C=S>>CSc1nc(F)cc2nnc(SCc3ccccc3)n12,,CCO,,CCN(CC)CC,,val
US20070197530A1,Nc1ccc(N2CCCC(OC(=O)N3C4CC5CC3CC(C4)O5)C2)c(F)c1.O=C(Cl)CCCCBr>>O=C1CCCCN1c1ccc(N2CCCC(OC(=O)N3C4CC5CC3CC(C4)O5)C2)c(F)c1,CN(C)c1ccncc1,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20150291595A1,COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1NC(=O)c1ccc(O)cc1.Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3Br)n(-c3ccccc3)c(=O)c12>>COc1ncc(-c2c(N)ncnc2N[C@@H](C)c2nn3ccc(C)c3c(=O)n2-c2ccccc2)cc1NC(=O)c1ccc(O)cc1,,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130079313A1,O=C(CO)OCc1ccccc1.O=Cc1cc(C(=O)O)ccc1OCC1CC1>>O=Cc1cc(C(=O)OCC(=O)OCc2ccccc2)ccc1OCC1CC1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20130158025A1,CCOC(=O)CC(=O)c1cccc(Cl)c1.Cc1n[nH]c(N)c1-c1ccc(Cl)cc1>>Cc1nn2c(-c3cccc(Cl)c3)cc(=O)[nH]c2c1-c1ccc(Cl)cc1,,c1ccncc1,,,,val
US04880809,COS(=O)(=O)OC.O=C1CCCCc2cc(O)c(O)cc21>>COc1cc2c(cc1O)C(=O)CCCC2,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140323501A1,CCOC(=O)C(CCc1ccc(Sc2ccccc2)cc1)(NC(C)=O)C(=O)OCC.O=C(Cl)CCl>>CCOC(=O)C(CCc1ccc(Sc2ccc(C(=O)CCl)cc2)cc1)(NC(C)=O)C(=O)OCC,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130116248A1,COc1ccc(Nc2c(N)cnc3ccc(Br)cc23)c(OC)c1.C[S-](C)C([S-])=NC#N>>COc1ccc(-n2c(=NC#N)[nH]c3cnc4ccc(Br)cc4c32)c(OC)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050070547A1,C[O-].FC(F)(F)c1cccnc1-c1cnc2c(Cl)cc(Cl)nc2c1>>COc1cc(Cl)c2ncc(-c3ncccc3C(F)(F)F)cc2n1,,C1CCOC1,,O,,val
US06534496B1,CCC(C(=O)O)C1CCN(C(C)=O)CC1.O=C(Cl)OCc1ccc([N+](=O)[O-])cc1>>CCC(C(=O)O)C1CCN(C(=O)OCc2ccc([N+](=O)[O-])cc2)CC1,,Cl,,,,val
US20100292236A1,CN(C)[C@@H]1CCNC1.O=C(NCC1(c2cccnc2)CCCCC1)c1sc(Br)nc1C(F)(F)F>>CN(C)[C@@H]1CCN(c2nc(C(F)(F)F)c(C(=O)NCC3(c4cccnc4)CCCCC3)s2)C1,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US06281216B1,COc1ccc(N2CCNCC2)cc1.N#CCCl>>COc1ccc(N2CCN(CC#N)CC2)cc1,,CC#N,,CCN(CC)CC,,val
US20150291604A1,Clc1cc(Cl)nc(N2CCOCC2)n1.O=S1(=O)OCCO1>>OCCc1c(Cl)nc(N2CCOCC2)nc1Cl,,C1CCOC1,,Cl,[Li]CCCC,val
US20090163512A1,CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2Cl)C12C(=O)Nc1cc(Cl)ccc12>>CC(C)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2Cl)C12C(=O)Nc1cc(Cl)ccc12)C(=O)O,,C1CCOC1,,O,[Na+].[OH-],val
US20140371238A1,CC(C)(C)OC(=O)N1CCC(Nc2ncccc2[N+](=O)[O-])CC1.O=Cc1ccccc1>>CC(C)(C)OC(=O)N1CCC(n2c(-c3ccccc3)nc3cccnc32)CC1,,CCO,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20080171743A1,C[C@H]1COCCN1.O=S(=O)(Cc1cc(Cl)nc(Cl)n1)c1ccccc1>>C[C@H]1COCCN1c1cc(CS(=O)(=O)c2ccccc2)nc(Cl)n1,,ClCCl,,CCN(CC)CC,,val
US20080114022A1,COC(=O)Cc1c(C)n(Cc2ccc(S(C)(=O)=O)cc2C(F)(F)F)c2nc(Cl)ccc12>>Cc1c(CC(=O)O)c2ccc(Cl)nc2n1Cc1ccc(S(C)(=O)=O)cc1C(F)(F)F,,C1CCOC1,CO,[Na+].[OH-],,val
US20150126371A1,COCN.O=C(O)c1cc(Br)cc(Br)c1>>CON(C)C(=O)c1cc(Br)cc(Br)c1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20120010189A1,CCOC(=O)c1nnc(-c2ccccc2)o1.Cc1cc(OC2CNC2)ccc1CN1CCC(C)(CO)CC1>>Cc1cc(OC2CN(C(=O)c3nnc(-c4ccccc4)o3)C2)ccc1CN1CCC(C)(CO)CC1,,CO,,[C-]#N.[Na+],,val
US20150344429A1,CCOC(=O)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(C2CC2)cn1)c1noc(C)n1>>Cc1nc(C(C)(NC(=O)c2cc(OCC(F)(F)F)c(C3CC3)cn2)C(=O)O)no1,,C1CCOC1,,O,,val
US20110118354A1,COC(=O)C1CCC(=O)C(C)(c2ccc(Cl)c(C(F)(F)F)c2)C1>>CC1(c2ccc(Cl)c(C(F)(F)F)c2)CC(CO)CCC1O,,CCO,,[BH4-].[Na+],,val
US05482942,CC(C)Oc1c(C2=CC(C)(C)Oc3ccc(C#N)cc32)c(=O)c1=O.N>>CC1(C)C=C(c2c(N)c(=O)c2=O)c2cc(C#N)ccc2O1,,CC#N,,,,val
US20070282101A1,CN(C)C=Nc1cc2cc[nH]c2cn1.O=C1CCC(=O)N1Br.O=S(=O)(Cl)c1ccccc1>>CN(C)C=Nc1cc2c(Br)cn(S(=O)(=O)c3ccccc3)c2cn1,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US06340704B1,CCOC(=O)c1cc2nc3c(cc2c2c1OC(C(=O)OCC)O2)C(c1ccc2c(c1)OCO2)OC3=O>>O=C1OCc2c1nc1ccc3c(c1c2-c1ccc2c(c1)OCO2)OCO3,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20160176824A1,CCC(=O)N[C@H]1CC[C@@H](NC(=O)OC(C)(C)C)C1.O=C(O)C(F)(F)F>>CCC(=O)N[C@H]1CC[C@@H](N)C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20130085161A1,CO.O=C(O)c1cccc2nc[nH]c12>>COC(=O)c1cccc2[nH]cnc12,CN(C)c1ccncc1,CO,,CC(C)N=C=NC(C)C,,val
US20140330026A1,C1CC2OC2C1.COC(=O)C(C)c1ccc(O)cc1F>>CC(C(=O)O)c1ccc(O[C@H]2CCC[C@@H]2O)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US05552397,CCOC(=O)CBr.C[C@@H]1CCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1>>CCOC(=O)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CCC[C@H]1C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US06313310B1,O=C1Nc2ccc(C#Cc3ccc([N+](=O)[O-])cc3)cc2/C1=C/c1ccc[nH]1>>Nc1ccc(C#Cc2ccc3c(c2)/C(=C/c2ccc[nH]2)C(=O)N3)cc1,[Zn],C1CCOC1,CO,O,[Cl-].[NH4+],val
US20160096839A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1ccc(N)c(Br)c1>>Cc1ccc(N)c(B2OC(C)(C)C(C)(C)O2)c1,,CS(C)=O,,CC(=O)[O-].[K+],,val
US04302464,C[Mg]Br.Cc1cc(C#N)ccn1.O>>CC(=O)c1ccnc(C)c1,,CCOCC,,Cl,,val
US20120171245A1,COC1CCCC(N=[N+]=[N-])C1O[Si](C)(C)C(C)(C)C>>COC1CCCC(N)C1O[Si](C)(C)C(C)(C)C,[Pd],CCOC(C)=O,,,,val
US05089498,CCCC(=O)c1cnc2c(C(=O)OC)cccc2c1Cl.Cc1ccccc1N>>CCCC(=O)c1cnc2c(C(=O)OC)cccc2c1Nc1ccccc1C,,C1COCCO1,,,,val
US20140135270A1,C=CCOc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc1.NS(=O)(=O)C1CC1>>C#CCOc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)NS(=O)(=O)C2CC2)cc1,,C1CCOC1,ClCCl,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US04210655,CC(=O)N1CCC(c2cc3ccccc3o2)CC1>>CCN1CCC(c2cc3ccccc3o2)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140243404A1,CC(C)=CCC/C(C)=C\CC/C(C)=C/COC(=O)OC(C)(C)C>>C1CC[C@H]2CCCC[C@H]2C1,,C[N+](=O)[O-],,,,val
US05578253,CC(=O)Cl.COC(=C(C(C)C)C(C)C)c1cccc(O)c1>>COC(=C(C(C)C)C(C)C)c1cccc(OC(C)=O)c1,,ClCCl,c1ccncc1,CCCCCC,CCOC(C)=O,val
US20110053940A1,COC/C=C/c1cc(/C=C/COC)cc(C(=O)NC2CC2)c1>>COCCCc1cc(CCCOC)cc(C(=O)NC2CC2)c1,[Pd],CCOC(C)=O,,[H][H],,val
US20090239854A1,C=Cc1ccc(C)nc1.Fc1ccc(N2CCc3[nH]c4ccc(Cl)cc4c3C2)cc1>>Cc1ccc(CCn2c3c(c4cc(Cl)ccc42)CN(c2ccc(F)cc2)CC3)cn1,,CN1CCCC1=O,,[K+].[OH-],,val
US05576335,CC(C)(C)c1cc(C(=O)O)cc(C(C)(C)C)c1O.COc1ccc(N)c([N+](=O)[O-])c1>>COc1ccc(-c2c(C(N)=O)cc(C(C)(C)C)c(O)c2C(C)(C)C)c([N+](=O)[O-])c1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04624954,Cc1c2n(c3ccc(Br)cc13)CCCC2=O>>Cc1c2n(c3ccc(Br)cc13)CCCC2O,,CO,,[BH4-].[Na+],,val
US20070135452A1,CC(C)N(c1ccc(Cl)cc1)c1cccc2nc(Cl)n(C)c12.COc1cc(Cl)cc(C)c1N>>COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(c3ccc(Cl)cc3)C(C)C)c2n1C.Cl,,CCOC(C)=O,,,,val
US20150031708A1,COc1cc(B(O)O)ccn1.Cc1cc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc(Cl)c1C>>COc1cc(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)cc(C)c2C)ccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US05037990,CCOC(=O)c1ccc(CCN)cc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>CCOC(=O)c1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20100305133A1,CCCC[Sn](CCCC)(CCCC)c1cccs1.COC(=O)c1c(OC)c(Br)cc2nc(OS(=O)(=O)C(F)(F)F)cnc12>>COC(=O)c1c(OC)c(Br)cc2nc(-c3cccs3)cnc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20090042892A1,Cc1nc(-c2ccccc2)sc1Br.O=C1CCC(=O)N1Br>>BrCc1nc(-c2ccccc2)sc1Br,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20050131022A1,CN(C)c1ccc([N+](=O)[O-])c(N2CCCCC2)c1>>CNc1ccc(NC)c(N2CCCCC2)c1,[Pd],,,CO,,val
US20020107391A1,CC(C)N(Cc1ccccc1)c1cccc(Br)n1>>CC(C)NCc1ccccc1,,Cc1ccccc1,,,,val
US20160229814A1,C#CCn1c(=O)n(CC)c(=O)c2cc(N)ccc21.CC(CC(=O)O)CC(=O)Nc1ccc(C#N)c(Cl)c1>>C#CCn1c(=O)n(CC)c(=O)c2cc(NC(=O)CC(C)CC(=O)Nc3ccc(C#N)c(Cl)c3)ccc21,,CCOC(C)=O,O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20100069629A1,CCN1CCN(c2cc(F)c(N)c(F)c2)CC1.COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4)cn2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCN1CCN(c2cc(F)c(NC(=O)N3CCc4c(-c5cnc(N(Cc6ccc(OC)cc6)Cc6ccc(OC)cc6)nc5)nc(N5CCOCC5)nc43)c(F)c2)CC1,,ClCCl,,c1ccncc1,,val
US04298739,CN(C(=O)CCCOc1ccc2c(ccc(=O)n2C)c1)C1CCCCC1>>CN1C(=O)CCc2cc(OCCCC(=O)N(C)C3CCCCC3)ccc21,[Pd],CO,,,,val
US20120214762A1,Nc1nc(Cl)cc(Cl)n1.O=C(O)c1n[nH]c2cc(I)ccc12>>Nc1nc(Cl)cc(-n2nc(C(=O)O)c3ccc(I)cc32)n1,,CN(C)C=O,,[H-].[Na+],,val
US20020094938A1,CC(=CC(=O)O)c1ccc(O)cc1O.CC1=C(CCC2(C)NCCCO2)C(C)(C)CCC1>>CC(=CC(=O)N1CCCOC1(C)CCC1=C(C)CCCC1(C)C)c1ccc(O)cc1O,CN(C)c1ccncc1,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20110034493A1,COC(OC)N(C)C.Cn1cnc(S(=O)(=O)n2cc(F)c(N)nc2=O)c1>>CN(C)C=Nc1nc(=O)n(S(=O)(=O)c2cn(C)cn2)cc1F,,CCOCC,,CN(C)C=O,,val
US04007175,CNC(=O)NC.O=C=Nc1ccccc1F>>CNC(=O)N(C)C(=O)Nc1ccccc1F,,Cc1ccccc1C,,,,val
US20100249186A1,CC(C)(C)OC(=O)NCC1CCNCC1.COC(=O)N1CCC(C=O)CC1>>COC(=O)N1CCC(CN2CCC(CNC(=O)OC(C)(C)C)CC2)CC1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040180902A1,CC(=O)O.CCC(=O)c1ccccc1.O=C1Nc2cc(F)c(F)cc2C1=O>>Cc1c(-c2ccccc2)nc2cc(F)c(F)cc2c1C(=O)O,,O,,Cl,,val
US20040058907A1,CC(C)(C)OC(=O)N1CCC(NC(=O)NCC2CN(Cc3ccc(Cl)c(Cl)c3)CCO2)CC1.Cl>>Cl.O=C(NCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1)NC1CCNCC1,,C1COCCO1,,,,val
US20100120741A1,C1CNCCN1.NNc1nc(Cl)nc2ccc(Cl)cc12>>NNc1nc(N2CCNCC2)nc2ccc(Cl)cc12,,CCO,,,,val
US20030216571A1,Cc1ccc2cc(F)c(Cl)cc2n1.O=Cc1ccc2c(c1)C(=O)c1ccccc1CO2>>O=C1c2ccccc2COc2ccc(/C=C/c3ccc4cc(F)c(Cl)cc4n3)cc21,,CC(=O)OC(C)=O,,,,val
US20100105667A1,CNC.COc1cc(OC)c(F)c(-c2ccc(C(=O)Nc3nc(C=O)c[nH]3)c3nccnc23)c1F>>COc1cc(OC)c(F)c(-c2ccc(C(=O)Nc3nc(CN(C)C)c[nH]3)c3nccnc23)c1F,,CO,ClCCl,Cl,,val
US20080182993A1,CC(C)(C)OC(=O)Nc1ccc(CC(=O)O)cc1>>CC(C)(C)OC(=O)Nc1ccccc1CCO,,C1CCOC1,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20120283297A1,CC(C)Oc1ncc(-c2nc(-c3cc4cn[nH]c4cc3Cl)no2)cc1Cl.CCOC(=O)CCCBr>>CCOC(=O)CCCn1ncc2cc(-c3noc(-c4cnc(OC(C)C)c(Cl)c4)n3)c(Cl)cc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140162967A1,CC(=O)OC[C@H]1O[C@@H](Oc2n[nH]c(C(C)C)c2Cc2ccc(/C=C/CCN3CCCC4(CCN(C(=O)OC(C)(C)C)CC4)C3)cc2C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.Cl.ClCCl>>CC(=O)OC[C@H]1O[C@@H](Oc2n[nH]c(C(C)C)c2Cc2ccc(/C=C/CCN3CCCC4(CCNCC4)C3)cc2C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.Cl.Cl,,ClCCl,,,,val
US20160168148A1,BrCc1ccccc1.Cc1cc2c(cc(Cl)c3nnc(C)n32)[nH]1>>Cc1cc2c(cc(Cl)c3nnc(C)n32)n1Cc1ccccc1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US04495187,COc1nc2cc(Cl)ccc2n2cnnc12>>Oc1nc2cc(Cl)ccc2n2cnnc12,,CC(=O)O,,Cl,,val
US20050027121A1,Cc1ccc(C[C@@H]2CNCCN2C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1C.O=Cc1cnn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c1>>Cc1ccc(C[C@@H]2CN(Cc3cn[nH]c3)CCN2C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1C,,ClCCCl,,O=C([O-])O.[Na+],,val
US20160220595A1,CC(C)(C)[Si](OC[C@@H]1CCC(=O)O1)(c1ccccc1)c1ccccc1.CI>>C[C@@H]1C[C@@H](CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)OC1=O,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US04028370,CC(C)c1cc2ccccn2n1.CN(C)C(=O)Cl>>CC(C)c1nn2ccccc2c1C(=O)N(C)C,,O=[N+]([O-])c1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US03989746,Cl.Nc1c(Cl)cc(Br)c2ccccc12>>Clc1cc(Br)c2ccccc2c1Cl,,O,,O=N[O-].[Na+],,val
US20030134873A1,CCOC(=O)N=C=S.COc1ccc(-c2ccccc2)c(N)n1.NO>>COc1ccc(-c2ccccc2)c2nc(N)nn12,,CCN(C(C)C)C(C)C,,Cl,,val
US20120165305A1,COCC(=O)Cl.O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cnn(C5CCNCC5)c4)cnn23)c1>>COCC(=O)N1CCC(n2cc(-c3cnn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CC1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20080207900A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)[C@H]1CC[C@@H](c2ccc(F)cc2)N1>>CCOC(=O)[C@H]1CC[C@@H](c2ccc(F)cc2)N1C(=O)OC(C)(C)C,,CCN(CC)CC,,CN(C)C=O,c1c[nH]cn1,val
US20070232627A1,CC(C)c1ccc2c(Nc3cc(C(=O)Nc4ccc(Br)cc4)ccc3Sc3ccc(NC(=O)OC(C)(C)C)cc3)ncnc2n1>>CC(C)c1ccc2c(Nc3cc(C(=O)Nc4ccc(Br)cc4)ccc3Sc3ccc(N)cc3)ncnc2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090143402A1,Cc1c(C(=O)Cl)c2ccccc2c(=O)n1-c1ccccc1.NN(c1ccccc1)c1ccccc1>>Cc1c(C(=O)NN(c2ccccc2)c2ccccc2)c2ccccc2c(=O)n1-c1ccccc1,,ClCCCl,,Cl,,val
US20070124152A1,COCCNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CC2CCN(C(=O)OCc3ccccc3)CC2)c1=O>>COCCNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CC2CCNCC2)c1=O,[Pd],CO,,,,val
US04045469,CCOC(=O)C1C(C)(C)C12C=CC=C2>>CCOC(=O)C1C(C)(C)C12CCCC2,,CCO,,[H][H],,val
US05200550,C=Cc1ccc(C(=O)OC)cc1C12CC3CC(CC(C3)C1)C2>>CCc1ccc(C(=O)OC)cc1C12CC3CC(CC(C3)C1)C2,[Pd],C1COCCO1,,,,val
US20100234377A1,CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)N3CCN(C(=O)c4cccc(F)c4)CC3)cc2F)CC1>>O=C(Nc1ccc(N2CCNCC2)c(F)c1)N1CCN(C(=O)c2cccc(F)c2)CC1,,CO,ClCCl,C1COCCO1,Cl,val
US20050020608A1,NC(=O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1.[OH-]>>O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1,,O,,Cl,,val
US20040248919A1,CCCC[SnH](CCCC)CCCC.CCOC(=O)C=C(C)C=C(F)S(=O)(=O)c1ccccc1>>CCCC[Sn](CCCC)(CCCC)C(F)=CC(C)=CC(=O)OCC,,c1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US05728376,BrBr.CCC=CCC=CCCCO>>CC/C=C\C/C=C\CCCBr,,ClCCl,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])O.[Na+],val
US20130345123A1,COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)OC(C)(C)C)C(=O)N21>>CC(C)(C)OC(=O)N[C@H]1CCS[C@H]2CCC[C@@H](C(=O)O)N2C1=O,,CO,,Cl,[Na+].[OH-],val
US04461724,CC(C)(C)OC(=O)N[C@@H](COCc1ccccc1)C(=O)O.Cc1ccc(S(=O)(=O)n2cnc(C[C@H](N)C(=O)N[C@@H](CCCCNC(=O)OCc3ccccc3)C(=O)OCc3ccccc3)c2)cc1>>Cc1ccc(S(=O)(=O)n2cnc(C[C@H](NC(=O)[C@H](COCc3ccccc3)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCCCNC(=O)OCc3ccccc3)C(=O)OCc3ccccc3)c2)cc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060199816A1,CCOC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccccc2Cl)C1>>O=C(O)[C@@H]1CCCN(S(=O)(=O)c2ccccc2Cl)C1,,C1CCOC1,,[Li+].[OH-],,val
US20150218160A1,CC(=O)c1cc(Cl)cnc1[C@@H](NC(=O)OC(C)(C)C)C(C)C>>CC(O)c1cc(Cl)cnc1[C@@H](NC(=O)OC(C)(C)C)C(C)C,,CCO,,[BH4-].[Na+],,val
US20030186872A1,CCN(CC)C(=O)c1ccc([C@H](c2ccccc2)N2C[C@@H](C)NC[C@@H]2C)cc1.Fc1cccc(CBr)c1>>CCN(CC)C(=O)c1ccc([C@H](c2ccccc2)N2C[C@@H](C)N(Cc3cccc(F)c3)C[C@@H]2C)cc1,,CC#N,,CCN(CC)CC,[I-].[Na+],val
US20120058988A1,N#Cc1cc(Br)ccc1F.OB(O)c1ccc(Cl)c(Cl)c1>>N#Cc1cc(-c2ccc(Cl)c(Cl)c2)ccc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20110034436A1,Cc1cc(NCCN)nc2ccccc12.Nc1c(F)c(F)c2c3c1c(=O)c(C(=O)O)cn3C1(CCCC1)CO2>>Cc1cc(NCCNc2c(F)c(N)c3c(=O)c(C(=O)O)cn4c3c2OCC42CCCC2)nc2ccccc12,,CS(C)=O,,CCN(CC)CC,,val
US20070213331A1,CCCN(C)C(=O)c1cnc(Cl)c(C(=O)OC)c1>>CCCN(C)C(=O)c1cnc(Cl)c(C(=O)O)c1,,CO,O,[Na+].[OH-],,val
US20110003807A1,CN(C)C=O.Cc1nn2ccsc2c1-c1nc(-c2ccccc2)c(C(=O)O)s1.On1nnc2ccccc21>>CON(C)C(=O)c1sc(-c2c(C)nn3ccsc23)nc1-c1ccccc1,,CN(C)C=O,,CCN=C=NCCCN(C)C,,val
US20050282863A1,CCCCN(C)CCCCCn1c2c(c3ccccc31)CCSc1ccccc1-2.O=C1O[C@H]([C@@H](O)CO)C(O)=C1O>>CCCCN(C)CCCCCn1c2c(c3ccccc31)CCSc1ccccc1-2.O=C1O[C@H]([C@@H](O)CO)C(O)=C1O,,CCO,,,,val
US20110070192A1,Clc1cc2nc[nH]c2cc1Cl.O=S(=O)(O[C@H]1CO[C@@H]2COC(c3ccccc3)O[C@H]2[C@H]1F)C(F)(F)F>>F[C@@H]1[C@@H]2OC(c3ccccc3)OC[C@H]2OC[C@H]1n1cnc2cc(Cl)c(Cl)cc21,,CS(C)=O,,[H-].[Na+],,val
US05104892,CS(=O)(=O)Cl.Nc1ccc(SCCCCl)cc1>>CS(=O)(=O)Nc1ccc(SCCCCl)cc1,,ClCCl,,c1ccncc1,,val
US20160060257A1,COc1ccc(F)cc1-c1ccnc2[nH]c(C3(O)CCN(C(=O)OC(C)(C)C)C3)cc12>>COc1ccc(F)cc1-c1ccnc2[nH]c(C3(O)CCNC3)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120214822A1,CNCCOc1ccccc1C(C)(C)Nc1nccn(-c2cc(C(=O)NC3CC3)ccc2C)c1=O.Cc1ccc(S(=O)(=O)O)cc1>>CNCCOc1ccccc1C(C)(C)Nc1nccn(-c2cc(C(=O)NC3CC3)ccc2C)c1=O.Cc1ccc(S(=O)(=O)O)cc1,,CO,,,,val
US20150031685A1,COC(=O)C(NC(=O)OC(C)(C)C)C1CCOCC1>>CC(C)(C)OC(=O)NC(C(=O)O)C1CCOCC1,,CO,O,[Na+].[OH-],,val
US04226775,COC(=O)[C@@H]1CCCN1C(=O)C(C)CC(=O)c1cccc(F)c1>>CC(CC(=O)c1cccc(F)c1)C(=O)N1CCC[C@H]1C(=O)O,,C1CCOC1,,Cl,[Na+].[OH-],val
US20140336207A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OCC1[C@@H]2CNC[C@H]12>>CC(C)(C)OC(=O)N1C[C@H]2C(CO)[C@H]2C1,,C1COCCO1,O,[Na+].[OH-],,val
US04188395,CCOC(=O)/C=C(/C)N.CCOC(=O)CC(=O)CN1C(=O)c2ccccc2C1=O.O=Cc1cccc(Cl)c1>>CCOC(=O)C1=C(C)NC(CN2C(=O)c3ccccc3C2=O)=C(C(=O)OCC)C1c1cccc(Cl)c1,,CCO,,,,val
US20080114006A1,CCn1c(=O)c(-c2ccc(F)c(N)c2)cc2cnc(S(C)=O)nc21.CN>>CCn1c(=O)c(-c2ccc(F)c(N)c2)cc2cnc(NC)nc21,,CCCCCC,ClCCl,C1CCOC1,O,val
US20150105403A1,CS(=O)(=O)c1cncc(Cl)n1.Oc1cccc(I)c1>>CS(=O)(=O)c1cncc(Oc2cccc(I)c2)n1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070167506A1,Cc1cccc(C(C)c2ncc[nH]2)c1C.O=C(Cl)Oc1ccc(F)cc1>>Cc1cccc(C(C)c2nccn2C(=O)Oc2ccc(F)cc2)c1C,,C1CCOC1,O,CCN(CC)CC,CCOC(C)=O,val
US20130190290A1,C1=COCCC1.N#Cc1cn[nH]c1>>N#Cc1cnn(C2CCCCO2)c1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140127156A1,O=C(O)/C=C/c1cccc2c1OCC2.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=NC(=O)/C=C/c1cccc2c1OCC2,,c1ccccc1,,CCN(CC)CC,,val
US20120277209A1,Fc1nccnc1C1CCCOCC1.O=C(c1ccc(O)cc1)c1nc2ccccc2[nH]1>>O=C(c1ccc(Oc2nccnc2C2CCCOCC2)cc1)c1nc2ccccc2[nH]1,,CN1CCCC1=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04690705,CCCS.O=C(c1cccs1)c1ccccc1Cl>>CCCSc1ccccc1C(=O)c1cccs1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20120316161A1,CC1(C)OB(c2ccc3occc3c2)OC1(C)C.CCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1Cl>>CCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc2occc2c1,,COCCOC,O,CCN(C(C)C)C(C)C,,val
US04729994,COC=Cc1cccc(Cl)c1Cl>>O=CCc1cccc(Cl)c1Cl,,C1CCOC1,O,[O-][Cl+3]([O-])([O-])O,,val
US20080114164A1,O=C(O)c1ncn2cc(Br)sc12.O=S(Cl)Cl>>O=C(Cl)c1ncn2cc(Br)sc12,,Cc1ccccc1,,,,val
US20160031819A1,NCCN.O=[N+]([O-])c1ccc(O)c2ncccc12>>NCCN.O=[N+]([O-])c1ccc(O)c2ncccc12,,C1CCOC1,,,,val
US20040082596A1,CNCc1ccc(OC)c(OC)c1.O=C(Cl)OC(Cl)(Cl)Cl>>COc1ccc(CN(C)C(=O)Cl)cc1OC,,c1ccncc1,,,,val
US20080119511A1,Brc1c(COC2CCCCO2)ccc2c1CCCC2.O=S(=O)(c1ccccc1)N(F)S(=O)(=O)c1ccccc1>>Fc1c(COC2CCCCO2)ccc2c1CCCC2,,C1CCOC1,,O,[Li]CCCC,val
US20070213397A1,CCN(CCCNCCCNC(C)=O)Cc1c2ccccc2cc2ccccc12.Cl>>CCN(CCCNCCCNC(C)=O)Cc1c2ccccc2cc2ccccc12.Cl,,CCO,,,,val
US20040077696A1,Cc1ccnc(N)c1.O=C(N=C=S)c1ccccc1>>Cc1ccnc(NC(=S)NC(=O)c2ccccc2)c1,,CC(C)=O,,,,val
US20160272617A1,Cc1cc(C(=O)NC2CCCNC2=O)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nc(C(F)(F)C(F)(F)C(F)(F)F)n[nH]3)cc2)cc1.Cl>>Cc1cc(C(=O)NC2CCCNC2=O)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc(-c3nc(C(F)(F)C(F)(F)C(F)(F)F)n[nH]3)cc2)cc1.Cl,,C1COCCO1,,,,val
US05177087,CC(=O)N1CCC(C(=O)c2ccc(N(C)C)cc2)CC1>>CC(=O)N1CCC(Cc2ccc(N(C)C)cc2)CC1,[Pd],CCO,,Cl,,val
US04227000,CCOC(=O)CC(=O)[O-].COc1ccc(C=O)cn1>>CCOC(=O)C=Cc1ccc(OC)nc1,C1CCNCC1,c1ccncc1,,,,val
US20150152216A1,CCCCC(O)c1ccncc1Br.C[SiH](C)Cl>>CCCCC1O[Si](C)(C)c2cnccc21,,C1CCOC1,,[Li]CCCC,,val
US20080214623A1,CC(C)OB(OC(C)C)OC(C)C.Cc1c(F)cc(C(=O)Nc2ccon2)cc1I>>Cc1c(F)cc(C(=O)Nc2ccon2)cc1B(O)O,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20130072492A1,CC1(c2ccccc2)C(=O)Nc2nc(N/N=C(\CCC(F)(F)C(F)(F)F)c3cc(Cl)ccc3Br)nc(N)c21>>CC1(c2ccccc2)C(=O)Nc2nc(-n3nc(CCC(F)(F)C(F)(F)F)c4cc(Cl)ccc43)nc(N)c21,[Cu]I,CN(C)C=O,,,,val
US20160068512A1,CC(C)(C)OC(=O)NC1CCNCC1.COC(=O)c1ccc(C(=O)Cl)cc1>>COC(=O)c1ccc(C(=O)N2CCC(NC(=O)OC(C)(C)C)CC2)cc1,,CCN(CC)CC,,ClCCl,,val
US20080119442A1,CSc1ccc2ccc(Br)cc2c1.O=C=O>>CSc1ccc2ccc(C(=O)O)cc2c1,,C1CCOC1,,[Li]CCCC,,val
US20140256933A1,O=C(NC1=N[C@@]2(c3cccs3)CN(C(=O)OCc3ccccc3)C[C@H]2CS1)c1ccccc1.O=C1CCC(=O)N1Br>>O=C(NC1=N[C@@]2(c3ccc(Br)s3)CN(C(=O)OCc3ccccc3)C[C@H]2CS1)c1ccccc1,,CCOC(C)=O,CN(C)C=O,,,val
US20020119961A1,O=C(CO)N1C2CCC1CC(Cc1ccc(F)cc1)C2.O=[N+]([O-])c1cc(Cl)cnc1Cl>>O=C(COc1ncc(Cl)cc1[N+](=O)[O-])N1C2CCC1CC(Cc1ccc(F)cc1)C2,,Cc1ccccc1,,[H-].[Na+],,val
US20140228348A1,C[Si](C)(C)C(F)(F)F.O=Cc1ccc(Br)cn1>>OC(c1ccc(Br)cn1)C(F)(F)F,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040176435A1,COc1cccc2ccsc12.Cc1ccc(S(=O)(=O)C#N)cc1>>COc1cccc2cc(C#N)sc12,,C1CCOC1,,[Li]CCCC,,val
US20060052606A1,O=C(NC(COCC1CCNCC1)c1ccccc1Cl)c1ccc2c(Cl)c[nH]c2c1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>O=C(NC(COCC1CCN(CC(F)(F)F)CC1)c1ccccc1Cl)c1ccc2c(Cl)c[nH]c2c1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US04897405,CC(=O)OCc1ccc2ccccc2c1Br>>OCc1ccc2ccccc2c1Br,,CO,O,[K+].[OH-],,val
US05864039,ClCCCCCBr.Oc1ccccc1>>ClCCCCCOc1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US05134128,BrBr.CCCCCCCCCCCCC(O)C1=CC(=O)OC1OC>>CCCCCCCCCCCCC(O)C1=C(Br)C(=O)OC1OC,CC(=O)O,ClC(Cl)(Cl)Cl,,c1ccncc1,,val
US04582833,CN(C)C=CC(=O)c1cccnc1.Nc1nnc(N2CCN(Cc3ccccc3)CC2)[nH]1>>c1ccc(CN2CCN(c3nc4nccc(-c5cccnc5)n4n3)CC2)cc1,,CC(=O)O,,,,val
US04727073,CC(=N)N.CCOC(=O)C(=CN(C)C)C(=O)c1ccc(OC)c(OC)c1>>CCOC(=O)c1cnc(C)nc1-c1ccc(OC)c(OC)c1,,CCO,,CCN(CC)CC,Cl,val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3cn[nH]c3c2)cc1.Cl>>Cc1cc(C(=O)NC2CCNCC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc3cn[nH]c3c2)cc1.Cl,,C1COCCO1,,O=C(O)C(F)(F)F,,val
US04786644,CCOC(=O)C1=C(O)c2ccccc2N(c2ccccc2)C1.Cc1cc(N)no1>>Cc1cc(NC(=O)C2=C(O)c3ccccc3N(c3ccccc3)C2)no1,,Cc1ccccc1,,,,val
US20120202785A1,Fc1ccc2nc(CCl)n(-c3ccccc3)c2c1.Nc1ncc2nc[nH]c2n1>>Nc1ncc2ncn(Cc3nc4ccc(F)cc4n3-c3ccccc3)c2n1,,CN(C)C=O,,[H-].[Na+],,val
US05420270,CC(C)COC(=O)Cl.NCc1ccncc1.O=C(O)c1ccccc1C(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21>>Cl.O=C(NCc1ccncc1)c1ccccc1C(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21,,ClCCl,,,,val
US04988381,Cc1n[nH]c(=O)n1N.O=S(=O)(Cl)c1ccccc1OC(F)(F)F>>Cc1n[nH]c(=O)n1NS(=O)(=O)c1ccccc1OC(F)(F)F,,c1ccncc1,,,,val
US20110086849A1,CCO.O=C(O)c1cccc([N+](=O)[O-])c1O>>CCOC(=O)c1cccc([N+](=O)[O-])c1O,,Cl,,,,val
US20070208013A1,COCCNC(=O)c1cn2ncnc(N)c2c1-c1ccc([N+](=O)[O-])cc1.C[Si](C)(C)CCOC(=O)Oc1ccc([N+](=O)[O-])cc1>>COCCNC(=O)c1cn2ncnc(NC(=O)OCC[Si](C)(C)C)c2c1-c1ccc([N+](=O)[O-])cc1,,CO,,CN(C)C=O,[H-].[Na+],val
US20150297761A1,CC(C)(C)OC(=O)CN1CCN(CC(=O)OC(C)(C)C)CCN(C[C@@H](N)C(=O)O)CCN(CC(=O)OC(C)(C)C)CC1.O=C(Cl)OCC1c2ccccc2-c2ccccc21>>CC(C)(C)OC(=O)CN1CCN(CC(=O)OC(C)(C)C)CCN(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)CCN(CC(=O)OC(C)(C)C)CC1,,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20110130409A1,CC(C)Oc1cnc(CBr)cn1.CCOC(=O)CC1CCc2c1[nH]c1ccc(O)cc21>>CCOC(=O)CC1CCc2c1[nH]c1ccc(OCc3cnc(OC(C)C)cn3)cc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050137171A1,CC(C)(C)OC(=O)N1c2ccccc2CC1c1nn(C(=O)OC(C)(C)C)c2ccc(OP(=O)(c3ccccc3)c3ccccc3)cc12>>O=P(Oc1ccc2[nH]nc(C3Cc4ccccc4N3)c2c1)(c1ccccc1)c1ccccc1,,C1COCCO1,,Cl,,val
US20080096874A1,COC(=O)C[C@@H]1CC[C@@H](c2ccc(NC(=O)C(=O)NN)cc2)CC1.S=C=Nc1cccnc1>>COC(=O)C[C@@H]1CC[C@@H](c2ccc(NC(=O)c3nnc(Nc4cccnc4)o3)cc2)CC1,,CC#N,,CCN=C=NCCCN(C)C,,val
US05358938,CCCOc1c(N)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1OC.OCCI>>CCCOc1c(NCCO)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070269500A1,COC(=O)CCCCCCCCC(=O)Cl.NC(=O)c1ccc(N)cc1O>>NC(=O)c1ccc(NC(=O)CCCCCCCCC(=O)O)cc1O,,CCN(CC)CC,,ClCCl,,val
US03984397,CC(=O)Nc1ccc(S(=O)(=O)NC2C(=O)N3[C@@H]2SC2(C)CC32C(=O)OCC(Cl)(Cl)Cl)cc1>>CC(=O)Nc1ccc(S(=O)(=O)NC2C(=O)N3[C@@H]2SC2(C)CC32C(=O)O)cc1,[Zn],CC(=O)O,,,,val
US20120238582A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)Cc1ccc2c(c1)C(=O)C(=O)N2>>CCOC(=O)Cc1ccc2c(c1)C(=O)C(=O)N2C(=O)OC(C)(C)C,CN(C)c1ccncc1,C1CCOC1,,,,val
US20110183997A1,Cc1cc2c(cn1)cc(-c1cc(N/C(N)=N/O)ccc1C)c(=O)n2C.O=C(O)C1(C(F)(F)F)CC1>>Cc1cc2c(cn1)cc(-c1cc(Nc3noc(C4(C(F)(F)F)CC4)n3)ccc1C)c(=O)n2C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120220589A1,COC(=O)c1ccc2nc(Br)c(N3CCCc4cc(F)ccc43)nc2c1.Cc1cc2cc(B3OC(C)(C)C(C)(C)O3)ccc2[nH]1>>COC(=O)c1ccc2nc(-c3ccc4[nH]c(C)cc4c3)c(N3CCCc4cc(F)ccc43)nc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US20150011532A1,CCOC(=O)c1nc(-c2cnc(Nc3ccc4ncsc4c3)cc2NC(C)C)oc1C(C)C>>CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(CO)c(C(C)C)o1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070197558A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc(Sc2ccc(OCc3cnc(Cl)s3)cc2[N+](=O)[O-])cc1>>CC(C)(C)OC(=O)Nc1ccc(Sc2ccc(OCc3cnc(Cl)s3)cc2[N+](=O)[O-])cc1,,C1COCCO1,,,,val
US20110172224A1,CCN=C=NCCCN(C)C.CN1CCOCC1.O=C(O)Cn1cc2c(n1)CCc1c-2sc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12>>CN(C)[C@H]1CCN(C(=O)Cn2cc3c(n2)CCc2c-3sc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c23)C1,,CN(C)C=O,,On1nnc2ccccc21,,val
US04305717,CCN(CC)C(=O)CNc1cc([N+](=O)[O-])ccc1OC>>CCN(CC)C(=O)CNc1cc(N)ccc1OC,[Fe],CC(=O)O,,O,,val
US20080045532A1,C1CCNC1.O=C(O)c1ccc(-n2nc(C(F)(F)F)c3c2CCCC3)cc1>>O=C(c1ccc(-n2nc(C(F)(F)F)c3c2CCCC3)cc1)N1CCCC1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20100249119A1,Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncc2nc(N)sc2n1.O=C(Cl)CCl>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncc2nc(NC(=O)CCl)sc2n1,,CC(=O)N(C)C,,O,,val
US20070155839A1,CCOC(=O)CCCBr.Oc1ccc(C(=C2CCCCCC2)c2ccc(O)cc2)cc1>>CCOC(=O)CCCOc1ccc(C(=C2CCCCCC2)c2ccc(O)cc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04155996,CC#N.CCOC(=O)CC(=S)OC.CO>>COc1cc(O)c(C#N)s1,,CO,,C[O-].[Na+],,val
US20020035272A1,COc1ccc(C(=O)O)cc1C1CCCC1.Cc1cc(Cc2ccc(Br)cc2)sc1C>>COc1ccc(C(=O)c2c(Cc3ccc(Br)cc3)sc(C)c2C)cc1C1CCCC1,CN(C)C=O,,,O=C(Cl)C(=O)Cl,,val
US20090099227A1,CC(C)(C)OC(=O)N1CCC(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)CC1.O=Cc1cc2ccncc2o1>>CC(C)(C)OC(=O)N1CCC(C=Cc2cc3ccncc3o2)CC1,,ClCCl,,[I-].[K+],,val
US20110212053A1,CC(C)(C#N)c1ccc(C(=O)c2c(O)cnc3ccc(Br)cc23)cc1.NO>>CC(C)(C#N)c1ccc(C(=NO)c2c(O)cnc3ccc(Br)cc23)cc1,,CCO,,Cl,,val
US20110009584A1,CC(=O)Oc1ccc(-c2nnc(-c3ccc(-c4nnc(-c5ccc(C(C)(C)C)cc5)o4)cc3)o2)cc1>>CC(C)(C)c1ccc(-c2nnc(-c3ccc(-c4nnc(-c5ccc(O)cc5)o4)cc3)o2)cc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20130059834A1,CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3n[nH]c4ccc(OC(F)F)cc34)nc12.ClCCCN1CCOCC1>>CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CCCN4CCOCC4)c4ccc(OC(F)F)cc34)nc12,,CN(C)C=O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],,val
US05800733,C1CCOC1.C=CC(=O)OCCCCCCCCOc1ccc(C(=O)O)cc1.CCN(CC)CC.CN(C)c1ccncc1.CS(=O)(=O)Cl.O.O=Cc1ccc(O)cc1>>C=CC(=O)OCCCCCCCCOc1ccc(C(=O)Oc2ccc(C=O)cc2OC(=O)c2ccc(OCCCCCCCCOC(=O)C=C)cc2)cc1,CN(C)c1ccncc1,C1CCOC1,O,,,val
US20100204196A1,CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCCN3C(=O)CN(C)C)nc2c1ccn2S(=O)(=O)c1ccc(C)cc1>>CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCCN3C(=O)CN(C)C)[nH]c2nccc1-2,,C1COCCO1,CCOC(C)=O,[K+].[OH-],,val
US20020091261A1,Clc1nnc(Cc2ccncc2)c2ccccc12.Oc1cccc(O)c1>>Oc1cccc(Oc2nnc(Cc3ccncc3)c3ccccc23)c1,,C1COCCO1,,C[O-].[Na+],,val
US05932601,Cc1oc(-c2ccccc2)nc1COc1ccc(CCCC2OC(=O)NC2=O)cc1OC(C)C>>Cc1oc(-c2ccccc2)nc1COc1ccc(CCCC2OC(=O)NC2=O)cc1O,Cl[Ti](Cl)(Cl)Cl,ClCCl,,Cl,,val
US20160023983A1,CC/C=C/Cc1cccc(CC(=O)OC)c1O>>CCCCCc1cccc(CC(=O)OC)c1O,,CO,,,,val
US04270948,CCOC(=O)C(C)Cl.Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1>>CCOC(=O)C(C)Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150141402A1,CC(C)(C)OC(=O)N1CC(O)C(F)(F)C1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CC(OS(=O)(=O)C(F)(F)F)C(F)(F)C1,,ClCCl,,c1ccncc1,,val
US04278748,CCCCCON=O.Cl.Nc1ccc(CCNS(=O)(=O)c2cccc3[nH]nnc23)cc1>>Cl.NNc1ccc(CCNS(=O)(=O)c2cccc3[nH]nnc23)cc1,,CCO,,,,val
US20050234036A1,CCOC(=O)CC#N.COCCCNC(N)=S>>COCCCn1c(N)cc(=O)[nH]c1=S,,CCO,,C[O-].[Na+],,val
US20130150376A1,CC(C)Oc1cc(CBr)ncc1OCc1ccccc1.C[C@H]1C[C@@]2(C=CS(=O)(=O)N2c2cccc(F)c2)CCN1>>CC(C)Oc1cc(CN2CC[C@]3(C=CS(=O)(=O)N3c3cccc(F)c3)C[C@@H]2C)ncc1OCc1ccccc1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US03931177,C=CCBr.O=C1CCC(c2cccc(O)c2)=NN1>>C=CCOc1cccc(C2=NNC(=O)CC2)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120220552A1,CCOC(=O)CBr.Clc1cccc(Cl)c1COc1ccc(C2CNCCO2)cc1>>CCOC(=O)CN1CCOC(c2ccc(OCc3c(Cl)cccc3Cl)cc2)C1,,CC#N,,CCN(CC)CC,Cl,val
US20140038954A1,COc1cc(F)c2c(c1)C(Cl)(c1ncc[nH]1)c1cc(Br)ccc1O2.N#CN>>COc1cc(F)c2c(c1)C1(N=C(N)n3ccnc31)c1cc(Br)ccc1O2,,C1COCCO1,,,,val
US20080312316A1,BrCc1ccccc1.CC(C)c1oc2c(C=O)c(O)ccc2c(=O)c1-c1ccc(Cl)cc1>>CC(C)c1oc2c(C=O)c(OCc3ccccc3)ccc2c(=O)c1-c1ccc(Cl)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04988689,BrCCc1ccccc1.Fc1ccc(Cn2c(NC3CCNC3)nc3ccccc32)cc1>>Fc1ccc(Cn2c(NC3CCN(CCc4ccccc4)C3)nc3ccccc32)cc1,,CN(C)C=O,O,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20050113370A1,CC(C)(C)OC(=O)n1nc(-c2ccccc2)c2ccc(N)cc21.O=Cc1ccccc1>>CC(C)(C)OC(=O)n1nc(-c2ccccc2)c2ccc(NCc3ccccc3)cc21,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140094462A1,CC1=CC[C@@H](C)C(=O)OC[C@@H](c2ccccc2)NC(=O)CC1>>CC1CCC(=O)N[C@H](c2ccccc2)COC(=O)[C@H](C)CC1,[Pd],C1CCOC1,,,,val
US20120225061A1,CCOC(=O)c1ncsc1NC(=O)OC(C)(C)C.O=C1CCC(=O)N1Br>>CCOC(=O)c1nc(Br)sc1NC(=O)OC(C)(C)C,,ClCCl,,,,val
US04085107,CCC(=O)OC1(c2ccccc2)CCN(CCNc2ccccc2C(N)=O)CC1.O.O=Cc1ccccc1.O=S(=O)(O)O>>CCC(=O)OC1(c2ccccc2)CCN(CCN2c3ccccc3C(=O)NC2c2ccccc2)CC1.O.O.O=S(=O)(O)O,,CCO,O,C1CCNCC1,,val
US20060173043A1,COC(=O)CCc1ccc(C)cc1>>Cc1ccc(CCCO)cc1,,C1CCOC1,,O,[Na+].[OH-],val
US20150284381A1,COc1ccc(Cn2cc(B3OC(C)(C)C(C)(C)O3)cn2)cc1.Nc1cc(Cl)ccn1>>COc1ccc(Cn2cc(-c3ccnc(N)c3)cn2)cc1,,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100168130A1,CCN(CC)C(=O)c1ccc([C@H](c2cccc([N+](=O)[O-])c2)N2CCNCC2)cc1.O=Cc1cccc(F)c1>>CCN(CC)C(=O)c1ccc([C@H](c2cccc(N)c2)N2CCN(Cc3cccc(F)c3)CC2)cc1,,ClCCCl,,O=C(O)C(F)(F)F,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120071489A1,COC(=O)COc1ccc(NC(=O)N2CCN(c3ccccc3C(C)(C)C)CC2)cc1>>CC(C)(C)c1ccccc1N1CCN(C(=O)Nc2ccc(OCC(=O)O)cc2)CC1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20100222359A1,COc1ccc(C(N)=O)c([N+](=O)[O-])c1>>NC(=O)c1ccc(O)cc1[N+](=O)[O-],,ClCCl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20160016880A1,O=C(OC12CCC(CO)(CC1)C2)c1cc(F)cc(F)c1>>O=CC12CCC(OC(=O)c3cc(F)cc(F)c3)(CC1)C2,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05306692,Cc1ccc(Oc2c(F)cc(C(F)(F)F)cc2Cl)cc1[N+](=O)[O-]>>Cc1ccc(Oc2c(F)cc(C(F)(F)F)cc2Cl)cc1N,,CC(C)O,,Cl,O,val
US20020058660A1,C[Si](C)(C)CC(O)CC(/C(F)=C(\F)Cc1cccc(Oc2ccccc2)c1)c1ccc(Cl)cc1>>C=CCC(/C(F)=C(\F)Cc1cccc(Oc2ccccc2)c1)c1ccc(Cl)cc1,O,CC(=O)O,,,,val
US06156757,Cl.NOc1ccccc1.OC1(O)CCNCC1>>Cl.c1ccc2c3c(oc2c1)CCNC3,,CC(C)O,,Cl,Cl,val
US20030073839A1,CC(C)(C)CC(C)(C)c1ccc(O)cc1.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)CC(C)(C)c1ccc(Oc2ccc([N+](=O)[O-])cc2)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040023971A1,CC(C)(C)OC(=O)N1CC2CCC(Cc3ccccc3)(C1)N2.Cl>>CC(C)(C)OC(=O)N1CC2CCC(C1)N2.Cl,[Pd],CO,,[H][H],,val
US05977174,CCCCCCCCCC=CC=CC=CC=CC=CC=CC(=O)OCCN(C)C.CI>>CCCCCCCCCC=CC=CC=CC=CC=CC=CC(=O)OCC[N+](C)(C)C.[I-],,ClCCl,,,,val
US20150087646A1,COC(=O)c1ccc(-n2nc(-c3c(C)cccc3Cl)[nH]c2=O)cc1OC.NC(=NO)c1ccc(Cl)cc1>>COc1cc(-n2nc(-c3c(C)cccc3Cl)[nH]c2=O)ccc1-c1nc(-c2ccc(Cl)cc2)no1,,C1CCOC1,,[H-].[Na+],,val
US20120142672A1,ClCCCBr.O=C(O)Cc1cc(F)c(F)c(F)c1>>O=C(O)C(CCCCl)c1cc(F)c(F)c(F)c1,,C1CCOC1,,[Li]CCCC,,val
US05328639,CCCCCCC(F)CBr.O=C(O)c1ccc(O)cc1>>CCCCCCC(F)COc1ccc(C(=O)O)cc1,,CCO,O,Cl,[K+].[OH-],val
US20100298293A1,CCC(OC(C)=O)c1cccnc1F>>CCCc1cccnc1F,[Pd],CCO,,[H][H],,val
US20030171418A1,CCOC(C)OC1COc2ccc3cnn(C[C@@H](C)N=[N+]=[N-])c3c2C1>>C[C@H](Cn1ncc2ccc3c(c21)CC(O)CO3)N=[N+]=[N-],,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US05238958,C=[N+]=[N-].Cc1ccc(C(=O)O)cc1O>>COC(=O)c1ccc(C)c(O)c1,,CCOCC,CCOCC,,,val
US20040009991A1,CC1=C(C(=O)OCCC#N)C(c2cccc(Cl)c2)C(C(=O)OCCC(c2ccccc2)c2ccccc2)=C(C)N1>>CC1=C(C(=O)O)C(c2cccc(Cl)c2)C(C(=O)OCCC(c2ccccc2)c2ccccc2)=C(C)N1,,CO,,Cl,[Na+].[OH-],val
US20040206940A1,COC(=O)C1CN2CCN3CCCN4CCN(C1)C2(C)C34C>>COC(=O)C1CNCCNCCCNCCNC1,,CO,,Cl,,val
US20100016315A1,NC(=O)c1cc(Cl)cc(CBr)c1.NC(=O)c1cc(Cl)cnc1N>>Br.N=c1c(C(N)=O)cc(Cl)cn1Cc1cc(Cl)cc(C(N)=O)c1,,CCOC(C)=O,CN(C)C=O,,,val
US05856334,Cl.NC1CCn2c(CCc3ccccc3)nc3cccc1c32>>Cl.NC1CCn2c(CCc3ccccc3)nc3cccc1c32,,CO,,,,val
US05008426,COP1Oc2ccccc2-c2ccccc21.COc1cc(C(=O)Cl)cc(OC)c1OC>>COc1cc(C(=O)P2(=O)Oc3ccccc3-c3ccccc32)cc(OC)c1OC,,Cc1ccccc1,,,,val
US20050131000A1,CC(C)(C)OC(=O)NCCOc1cnsn1.Cl>>Cl.NCCOc1cnsn1,,C1COCCO1,,,,val
US20140051672A1,COc1cc(-n2cccn2)ccc1-c1ccc(C2=CCN(C(=O)OC(C)(C)C)CC2)nn1>>Oc1cc(-n2cccn2)ccc1-c1ccc(C2=CCNCC2)nn1,,ClCCl,,BrB(Br)Br,,val
US05250549,COc1ccc(S(=O)(=O)Cl)cc1.Nc1ccccc1N>>COc1ccc(S(=O)(=O)Nc2ccccc2N)cc1,,C1COCCO1,,CCN(CC)CC,,val
US05155122,COC(=O)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1.COCCOCCl>>COCCOCOc1c(C(C)(C)C)cc(C(=O)OC)cc1C(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,[Cl-].[NH4+],val
US03952001,CC(C)S(=O)c1nc[nH]n1.CCCN(CCC)C(=O)Cl>>CCCN(CCC)C(=O)n1cnc(S(=O)C(C)C)n1,,CCN(CC)CC,,C1CCOC1,,val
US20130231352A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)Cc1ccccn1.O=C1Nc2ccc(F)cc2C1=O>>CC(NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2c(C(=O)O)c1-c1ccccn1,,CCO,O,[K+].[OH-],,val
US20080280933A1,CN.O=[N+]([O-])c1cccc(Br)c1Cl>>CNc1c(Br)cccc1[N+](=O)[O-],,CCO,,,,val
US20160176850A1,C[C@H](COC(=O)c1ccccc1)NC(=O)c1cc(Cl)nc(Cl)n1.c1cnc2[nH]nc(C3CCNCC3)c2c1>>C[C@H](COC(=O)c1ccccc1)NC(=O)c1cc(N2CCC(c3n[nH]c4ncccc34)CC2)nc(Cl)n1,,CO,,CCOC(C)=O,Cl,val
US20110105459A1,CC(C)=O.CNC(=O)c1ccc(OC2CN(C(=O)N3CCCNCC3)C2)cn1>>CNC(=O)c1ccc(OC2CN(C(=O)N3CCCN(C(C)C)CC3)C2)cn1,,CC#N,,,,val
US20150018341A1,CCC(=C(c1ccc(O)cc1)c1ccc(Cl)nc1)c1ccc2c(c1)CCO2.CNCCO>>CCC(=C(c1ccc(O)cc1)c1ccc(OCCNC)nc1)c1ccc2c(c1)CCO2,,C1CCOC1,,[H-].[Na+],,val
US20070010542A1,CC1(C)OCC(OCc2ccccc2)CO1>>OCC(CO)OCc1ccccc1,,CO,,,,val
US20100305096A1,CC(C)(C)OC(=O)N1CC(N2CCNC(=O)C2)C1>>O=C1CN(C2CNC2)CCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150344423A1,C=CCBr.CON(C)C(=O)c1cc(-c2cc(C(C)(C)C)cc(C(C)(C)C)c2)n(CC2CCCCC2)c1C>>C=CCC(=O)c1cc(-c2cc(C(C)(C)C)cc(C(C)(C)C)c2)n(CC2CCCCC2)c1C,,C1CCOC1,CCOCC,II,,val
US04282028,CC(=O)CCC(C)=O.NN1C(=O)c2ccccc2C1=O>>Cc1ccc(C)n1N1C(=O)c2ccccc2C1=O,,CC(=O)O,ClCCl,,,val
US20150050410A1,COc1ccc(C2CC(=O)c3c(O)cc(O)cc3O2)cc1O.O=S1(=O)CCCO1>>COc1ccc(C2CC(=O)c3c(O)cc(OCCCS(=O)(=O)O)cc3O2)cc1O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04257802,CNc1nc(C)cc(OC)n1.O=C=NS(=O)(=O)c1cc(Cl)ccc1Cl>>COc1cc(C)nc(N(C)C(=O)NS(=O)(=O)c2cc(Cl)ccc2Cl)n1,,CC#N,,C1CN2CCN1CC2,,val
US06239131B1,CC(C)(C)C(=O)Cl.Cc1ccc2c(c1)NC(=O)C(NC(=O)OC(C)(C)C)CN2>>Cc1ccc2c(c1)NC(=O)C(NC(=O)OC(C)(C)C)CN2C(=O)C(C)(C)C,,ClCCl,,O,c1ccncc1,val
US20130150361A1,NNc1ccc(F)cn1.O=C(Cl)c1ccccc1Cl>>O=C(NNc1ccc(F)cn1)c1ccccc1Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100016396A1,CC(C)c1nn(C)c(Oc2cc(O)c(Cl)cc2Cl)c1C=O.C[Si](C)(C)C[Mg]Cl>>C=Cc1c(C(C)C)nn(C)c1Oc1cc(O)c(Cl)cc1Cl,,C1CCOC1,CCOC(C)=O,Cl,,val
US05556977,COC(=O)CNC(=O)COc1ccc(C(C)=O)cc1.O=C1CCC(=O)N1Br>>COC(=O)CNC(=O)COc1ccc(C(=O)CBr)cc1,,ClC(Cl)(Cl)Cl,,,,val
US20030069239A1,COc1ccc(Cl)c(N)c1.FC(F)(F)c1ccc(-c2nc(Cl)cc(C(F)(F)F)n2)cn1>>COc1ccc(Cl)c(Nc2cc(C(F)(F)F)nc(-c3ccc(C(F)(F)F)nc3)n2)c1,,CCO,O,Cl,[Na+].[OH-],val
US20160039773A1,CN(C)C(=O)Cl.COC(=O)/C=C/n1nn[nH]c1=O>>COC(=O)/C=C/n1nnn(C(=O)N(C)C)c1=O,CN(C)c1ccncc1,Cc1ccccc1,,,,val
US04360466,CN(C)C=Nc1c(Cl)cc(N)cc1Cl.COc1ccc(C=O)cc1F>>COc1ccc(C=Nc2cc(Cl)c(N=CN(C)C)c(Cl)c2)cc1F,,CO,,,,val
US20100311747A1,CC#N.O=C(O)C(F)(F)F.O=C1CC2CNCC2C1>>CC(=O)N1CC2CC(=O)CC2C1,,CC#N,,CCN(CC)CC,,val
US20140378459A1,CC(C)(C)OC(=O)CN(Cc1cccc(C(=O)OC(C)(C)C)c1)C(=O)c1ccc2cc(OC(=O)c3ccc(NC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)cc3)ccc2n1>>N=C(N)Nc1ccc(C(=O)Oc2ccc3nc(C(=O)N(CC(=O)O)Cc4cccc(C(=O)O)c4)ccc3c2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120258948A1,COc1ccc(-c2ccn(CC[C@](C)(C(=O)NOC3CCCCO3)S(C)(=O)=O)c(=O)c2)c(F)c1F>>COc1ccc(-c2ccn(CC[C@](C)(C(=O)NO)S(C)(=O)=O)c(=O)c2)c(F)c1F,,C1COCCO1,,Cl,,val
US20070185101A1,C=C(C)[C@@H]1CC[C@@H](C)[C@@]2(O)[C@H]1C=C(C)[C@@H](O)[C@@H]2OC(=O)[C@@H]1C[C@@]2(O)c3cccc(Cl)c3N(C)O[C@H]2N1.O=C(O)C1CC1>>C=C(C)[C@@H]1CC[C@@H](C)[C@@]2(O)[C@H]1C=C(C)[C@@H](OC(=O)C1CC1)[C@@H]2OC(=O)[C@@H]1C[C@@]2(O)c3cccc(Cl)c3N(C)O[C@H]2N1,CN(C)c1ccncc1,C1CCOC1,,CCN=C=NCCCN(C)C,Cl,val
US05591762,CCCc1nc2c(C)cc(-c3cn(C(CCC)CCC)cn3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCc1nc2c(C)cc(-c3cn(C(CCC)CCC)cn3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050043337A1,CC(C)(N)Cc1ccc(Oc2ccc(O)cc2)cc1.c1ccc2c(c1)[nH]c1cccc(OC[C@@H]3CO3)c12>>CC(C)CN(C[C@H](O)COc1cccc2[nH]c3ccccc3c12)c1ccc(Oc2ccc(O)cc2)cc1,,CCO,,,,val
US05488152,CCO.O=C1OC(=O)c2c(F)c(F)c(F)c(F)c21>>CCOc1c(F)c(F)cc(C(=O)O)c1F,,O,,[Li+].[OH-],,val
US20130059856A1,CC(=O)c1c(F)ccc(F)c1F.C[Mg]Br>>CC(C)(O)c1c(F)ccc(F)c1F,,C1CCOC1,,,,val
US20140206618A1,CC(C)(C)OC(=O)N1CCN[C@H](CO)C1.N#Cc1c(F)ccc(C2CO2)c1F>>CC(C)(C)OC(=O)N1CCN(CC(O)c2ccc(F)c(C#N)c2F)[C@H](CO)C1,,CCO,,,,val
US20110028486A1,N#Cc1ccc2[nH]c(C(F)(F)F)cc2c1>>NCc1ccc2[nH]c(C(F)(F)F)cc2c1,,C1CCOC1,,,,val
US04352811,Cc1[nH]c2ccccc2c1CCCS(=O)(=O)c1ccccc1.Clc1ccc2c(C3CCNCC3)noc2c1>>Cc1[nH]c2ccccc2c1CCCN1CCC(c2noc3cc(Cl)ccc23)CC1,,CCC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110046147A1,COc1ccc(-c2csc(-c3cccc(OC)c3)c2)cc1>>Oc1ccc(-c2csc(-c3cccc(O)c3)c2)cc1,,CCCCCC,CCOC(C)=O,,,val
US20080269196A1,N#Cc1ccc(C2(CSCC(F)(F)F)OCCO2)cc1>>NCc1ccc(C2(CSCC(F)(F)F)OCCO2)cc1,,C1CCOC1,,,,val
US04242344,C#CCN.O=C(O)c1cnc(Cl)c(Cl)n1>>C#CCNc1ncc(C(=O)O)nc1Cl,,C1COCCO1,,,,val
US20090054478A1,CCCCCCN=C=O.Cc1cc(Cl)nc2[nH]nc(O)c12>>CCCCCCNC(=O)n1[nH]c2nc(Cl)cc(C)c2c1=O,,C1CCOC1,,,,val
US05270311,CC(=O)Oc1ccc(CC(=O)Cl)cc1.CCCN>>CCCNC(=O)Cc1ccc(OC(C)=O)cc1,,CCOCC,O,,,val
US20120142707A1,C=C(C)[C@@H]1CC[C@]2(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05674886,CC(=O)OC(C)=O.O=[N+]([O-])c1ccc(Nn2cnnc2)cc1>>CC(=O)N(c1ccc([N+](=O)[O-])cc1)n1cnnc1,,c1ccncc1,,,,val
US20100286116A1,CCCCc1noc(C)c1/C=C/c1nc(C)c(C(=O)OC)s1>>CCCCc1noc(C)c1/C=C/c1nc(C)c(C(=O)O)s1,,C1CCOC1,O,CO,[Li+].[OH-],val
US20040072829A1,CC(C(=O)O)c1ccc(Cl)cc1>>OCCCc1ccc(Cl)cc1,,Cl,,C1CCOC1,,val
US20090192176A1,Clc1nc(C2=CCOCC2)c2cnn(C3CCCCO3)c2n1>>Clc1nc(C2=CCOCC2)c2cn[nH]c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150166480A1,CC(C)(O)CN1CCC(COc2ccc(Br)c(F)c2)CC1.CCN(CC)S(F)(F)F>>CC(C)(F)CN1CCC(COc2ccc(Br)c(F)c2)CC1,,ClCCl,,[Cl-].[NH4+],,val
US20090130076A1,CC(C)(C)OC(=O)Nc1nc2c(-c3cccc(Br)c3)cc(C=O)cc2s1.Fc1ccc([Mg]Br)cc1>>CC(C)(C)OC(=O)Nc1nc2c(-c3cccc(Br)c3)cc(C(O)c3ccc(F)cc3)cc2s1,,C1CCOC1,,[Cl-].[NH4+],,val
US20120322837A1,CC(C)CC1CC(c2onc(C(CCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)CC(=O)OC(C)(C)C)c2I)C1.CC1(C)OB(C2CC2)OC1(C)C>>CC(C)CC1CC(c2onc(C(CCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)CC(=O)OC(C)(C)C)c2C2CC2)C1,,CN(C)C=O,,,,val
US20090306105A1,O=S(Cl)Cl.O=c1[nH]cnc2cc(O[C@H]3CCOC3)c(O[C@H]3CCOC3)cc12>>Clc1ncnc2cc(O[C@H]3CCOC3)c(O[C@H]3CCOC3)cc12,,CC#N,,CN(C)C=O,,val
US20050234112A1,CC(=O)OC(CNC(C)(C)CCn1cnnc1)c1ccc(OCc2ccccc2)c(CO)c1>>CC(C)(CCn1cnnc1)NCC(O)c1ccc(O)c(CO)c1,[Pd],CO,,[H][H],,val
US20140357664A1,C[C@@H]1N[C@@H](CO[Si](C)(C)C(C)(C)C)Cc2c(CCC(C)(C)O)cccc21.O=C(O)Cc1c(Cl)cccc1Cl>>C[C@H]1c2cccc(CCC(C)(C)O)c2C[C@H](CO[Si](C)(C)C(C)(C)C)N1C(=O)Cc1c(Cl)cccc1Cl,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20100075948A1,CC(C)(C)C[C@@H]1N[C@@H](C(=O)N[C@@H]2CC[C@@H](N)CC2)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F.CCN(CC)CC.O=C(O)C(F)(F)F>>CC(C)(C)C[C@@H]1N[C@@H](C(=O)N[C@@H]2CC[C@@H](NC(N)=O)CC2)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F,,C1COCCO1,,,,val
US20120251551A1,N#Cc1ccc(Cl)nc1.OCCN1CCOCC1>>N#Cc1ccc(OCCN2CCOCC2)nc1,,CN(C)C=O,,[H-].[Na+],,val
US04826963,CC(C)Oc1ccc2c(=O)c(-c3ccccc3)coc2c1.OC[C@H]1OC2O[C@@H]3[C@@H](CO)O[C@H](O[C@@H]4[C@@H](CO)O[C@H](O[C@@H]5[C@@H](CO)O[C@H](O[C@@H]6[C@@H](CO)O[C@H](O[C@@H]7[C@@H](CO)O[C@H](O[C@@H]8[C@@H](CO)OC(OC9[C@H](O)[C@@H](O)C(O[C@@H]9CO)C1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O>>CC(C)Oc1ccc2c(=O)c(-c3ccccc3)coc2c1.OC[C@H]1OC2O[C@@H]3[C@@H](CO)O[C@H](O[C@@H]4[C@@H](CO)O[C@H](O[C@@H]5[C@@H](CO)O[C@H](O[C@@H]6[C@@H](CO)O[C@H](O[C@@H]7[C@@H](CO)O[C@H](O[C@@H]8[C@@H](CO)OC(OC9[C@H](O)[C@@H](O)C(O[C@@H]9CO)C1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O,,CC(C)=O,,O,,val
US20130296373A1,COc1ccnc(C(=O)N[C@H]2COC(=O)[C@H](Cc3ccccc3)[C@@H](O)[C@H](C)OC2=O)c1O>>C[C@@H]1OC(=O)[C@H](Cc2ccccc2)[C@H]1O,,Cl,,,,val
US20070032515A1,COc1ccc(C(C#N)C(=O)C(C)C)cc1OC.NN.O=C(O)C(F)(F)F.O=Cc1ccc(O)cc1>>COc1cc2c(-c3ccc(O)cc3)nc3[nH]nc(C(C)C)c3c2cc1OC.O=C(O)C(F)(F)F,,CCO,,,,val
US20130190289A1,C1COCCN1.CC[C@H](NC(=O)OC(C)(C)C)C(=O)O>>CC[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCOCC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100273786A1,CC(C)(C)OC(=O)N[C@@H](CC(=O)N1CCn2c(C(F)(F)F)nc(C(=O)N3CC[C@@H](O)C3)c2C1)Cc1cc(F)c(F)cc1F.Cl>>Cl.N[C@@H](CC(=O)N1CCn2c(C(F)(F)F)nc(C(=O)N3CC[C@@H](O)C3)c2C1)Cc1cc(F)c(F)cc1F,,CCOC(C)=O,,,,val
US20060035938A1,CCOC(=O)CC(=O)Nc1ccc(Cl)cc1.COC=CC(C)=O>>CCOC(=O)c1ccc(C)n(-c2ccc(Cl)cc2)c1=O,,CCO,,C[O-].[Na+],,val
US20080096874A1,COC(=O)C[C@@H]1CC[C@@H](c2ccc(NC(=O)C(=O)OC)cc2)CC1.NN>>COC(=O)C[C@@H]1CC[C@@H](c2ccc(NC(=O)C(=O)NN)cc2)CC1,,CCO,,O,,val
US20070249670A1,CC(C)(C)OC(=O)CC#N.COC(=O)CS>>CC(C)(C)OC(=O)c1ccsc1N,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,O,val
US20110262352A1,COCc1ccccc1N1CCN(C(=O)[C@H]2COc3ccccc3O2)CC1>>COCc1ccccc1N1CCN(C[C@H]2COc3ccccc3O2)CC1,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20030195226A1,CCBr.CCCCOc1ccc(CC(=O)OC)cc1>>CCCCOc1ccc(C(CC)C(=O)OC)cc1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20100168080A1,CC(C)(C)OC(=O)N(CCCOS(C)(=O)=O)Cc1ccccc1.Fc1ccc(CC2CNCCCO2)cc1>>CC(C)(C)OC(=O)N(CCCN1CCCOC(Cc2ccc(F)cc2)C1)Cc1ccccc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100087427A1,COCCCn1ccc2ccc(C(=O)N(C[C@H]3CN(C(=O)OC(C)(C)C)C[C@@H]3Cc3ccccc3)C(C)C)cc21>>COCCCn1ccc2ccc(C(=O)N(C[C@H]3CNC[C@@H]3Cc3ccccc3)C(C)C)cc21,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20130023696A1,COC(=O)C(N)CSCc1ccccc1.NC(CO)CSCc1ccccc1>>NC(CO)CSCc1ccccc1.NC(CSCc1ccccc1)C(=O)O,,CO,,,,val
US20130267546A1,CC#N.COC(=O)CC(=O)OC>>COC(=O)C(C(=O)OC)=C(C)N,,ClCCCl,,Cl[Sn](Cl)(Cl)Cl,,val
US20070203159A1,CN.COc1ccc(Cn2cnc3c(-c4ccco4)nc(Cl)nc32)cc1>>CNc1nc(-c2ccco2)c2ncn(Cc3ccc(OC)cc3)c2n1,,C1CCOC1,O,,,val
US20070232645A1,CC(=O)Nc1ccc(Sc2ccc(OCc3cccc(C)c3)cc2N)cc1.Cc1ccc2c(Cl)ccnc2n1>>CC(=O)Nc1ccc(Sc2ccc(OCc3cccc(C)c3)cc2Nc2ccnc3nc(C)ccc23)cc1,,CCO,,,,val
US20130225679A1,C[C@H]1C(=O)[C@H](CN(C)CCc2ccccc2)[C@@H]2C[C@H]1C2(C)C.Oc1cccc(Br)c1>>C[C@@H]1[C@H]2C[C@@H]([C@@H](CN(C)CCc3ccccc3)[C@]1(O)c1cccc(O)c1)C2(C)C,,C1CCOC1,,[Li]C(C)(C)C,,val
US20130245021A1,CCCCNc1ccc2ncc(-c3ccc4c(c3)CCC4=O)n2n1.[NH4+]>>CCCCNc1ccc2ncc(-c3ccc4c(c3)CCC4N)n2n1,,CO,,[BH3-]C#N.[Na+],,val
US20080194653A1,CC(C(=O)NC1=NN(C(=O)C(C)(C)C)C(CCCC(=O)NCCO)(c2ccccc2)S1)c1ccccc1.CC(C)(C)[Si](C)(C)Cl>>CC(C(=O)NC1=NN(C(=O)C(C)(C)C)C(CCCC(=O)NCCO[Si](C)(C)C(C)(C)C)(c2ccccc2)S1)c1ccccc1,,ClCCl,O,Cl,c1ccncc1,val
US20080221163A1,CN.COc1ccc(S(=O)(=O)Cl)cc1Br>>CNS(=O)(=O)c1ccc(OC)c(Br)c1,,C1CCOC1,,,,val
US20120077781A1,Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCCCCCC(=O)OC(C)(C)C)c2cc1Cl.NCC(O)CO>>Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCCCCCC(=O)OC(C)(C)C)c2cc1NCC(O)CO,,CS(C)=O,,,,val
US20110152290A1,COc1ccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)cc1C(=O)c1ccccc1C>>COc1ccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)cc1C(O)c1ccccc1C,,CCO,CO,[BH4-].[Na+],,val
US20110201604A1,CN1CCNCC1.C[C@@H](NC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(Cl)cc3s1)n2C)C(=O)O>>C[C@@H](NC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(Cl)cc3s1)n2C)C(=O)N1CCN(C)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050124654A1,NC1CCCc2nc(CCO)ncc21.O=C(O)CC(NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1>>O=C(CC(NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)NC1CCCc2nc(CCO)ncc21,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20060014739A1,CCOC(=O)C1CCCNC1.N#Cc1ccc(F)c2ccccc12>>CCOC(=O)C1CCCN(c2ccc(C#N)c3ccccc23)C1,,c1ccncc1,,CCOC(C)=O,,val
US20060264429A1,CN(C)C=O.COc1cccc(NC(=O)C(C)(C)C)c1>>COc1cccc(NC(=O)C(C)(C)C)c1C=O,,C1CCOC1,CCCCCC,,,val
US20070213371A1,BrP(Br)Br.N#Cc1cc(CO)cc(C(F)(F)F)c1>>N#Cc1cc(CBr)cc(C(F)(F)F)c1,,ClCCl,,,,val
US05411980,CCC(=O)Br.CCCCc1nn(-c2cc(N)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1>>CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1,CN(C)c1ccncc1,,,,,val
US20140094465A1,COc1cccc(OC)c1.O=C(Br)CBr>>COc1ccc(C(=O)CBr)c(OC)c1,,Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US05935972,FC(F)(F)c1nnnn1-c1cc(C2OCCCO2)c2occc2c1>>O=Cc1cc(-n2nnnc2C(F)(F)F)cc2ccoc12,,C1CCOC1,,Cl,,val
US20100168103A1,O=C(N1CCCCC1)C1(c2ccccc2)CCN(Cc2ccccc2)CC1>>c1ccc(CN2CCC(CN3CCCCC3)(c3ccccc3)CC2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110184029A1,COC(=O)c1cc(C)cc(CO)c1>>COC(=O)c1cc(C)cc(C=O)c1,,CCOCC,ClCCl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US04539324,ClCOCc1ccccc1.O=c1ncc(Cl)c[nH]1>>O=c1ncc(Cl)cn1COCc1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US20090036453A1,C[Si](C)(C)CCOCCl.C[Si](C)(C)CCOCn1ccc2c(=O)[nH]ncc21>>C[Si](C)(C)CCOCn1ncc2c(ccn2COCC[Si](C)(C)C)c1=O,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20100210660A1,COC(=O)c1ccc(Oc2ccc(OCc3c(-c4c(Cl)cccc4Cl)noc3C(C)C)nn2)cc1>>CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(Oc2ccc(C(=O)O)cc2)nn1,,CCO,,O,[Na+].[OH-],val
US20150073019A1,COC(OC)N(C)C.O=c1cc(-c2cccc(I)c2)[nH]n1-c1nc2ccccc2s1>>CN(C)C=C1C(=O)N(c2nc3ccccc3s2)N=C1c1cccc(I)c1,,C1CCOC1,,CCOCC,,val
US20020065276A1,COC(C)(C)C.O=C([O-])[O-].O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNC[C@H]1Cc1c[nH]c2ccccc12>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1,,C1CCOC1,COC(C)(C)C,O,,val
US20070129346A1,CC(=O)Cl.C[C@H](CO)C(=O)O>>CC(=O)OC[C@@H](C)C(=O)O,,c1ccncc1,,,,val
US20030149056A1,C1CCNC1.CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccc4)c(Cl)c3)c2cc1NC(=O)/C=C/CBr.CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccc4)c(Cl)c3)c2cc1NC(=O)/C=C/CCl.CN(C)C=O>>CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccc4)c(Cl)c3)c2cc1NC(=O)CC(CN1CCCC1)N1CCCC1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20100158818A1,CC1(C)CCN(CCC(C)(C)NC(=O)OCc2ccccc2)CC1.CI>>CC1(C)CC[N+](C)(CCC(C)(C)NC(=O)OCc2ccccc2)CC1.[I-],,CCO,,,,val
US20020013356A1,CC(=O)OC(C)=O.O=C1c2ccccc2C2CCCCC12>>CC(=O)C12CCCCC1c1ccccc1C2=O,,CC(=O)OC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20040176433A1,CC(C)(C)[Si](C)(C)Cl.OCCNN=C(Cc1ccncc1)c1ccc(F)cc1>>CC(C)(C)[Si](C)(C)OCCNN=C(Cc1ccncc1)c1ccc(F)cc1,,CN(C)C=O,,O,c1c[nH]cn1,val
US06020357,CI.O=[N+]([O-])c1ccc(N2CCNC2=S)cc1>>CSc1nccn1-c1ccc([N+](=O)[O-])cc1,,CC(C)=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20120108568A1,COc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)O)c2n1.NC[C@@H](O)CO>>COc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC[C@@H](O)CO)c2n1,,CCOC(C)=O,CO,,,val
US20160096834A1,CC(C)(C)OC(=O)NCc1ccc(-c2ccnc(N)c2N)cc1F.O=Cc1ccc(CN2CCOCC2)cn1>>CC(C)(C)OC(=O)NCc1ccc(-c2ccnc3nc(-c4ccc(CN5CCOCC5)cn4)[nH]c23)cc1F,,CN(C)C=O,,,,val
US20090023746A1,CN(C(=O)OC(C)(C)C)C1CCNCC1.Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(CC3CC3)cc(C=O)c2c1>>CNC1CCN(Cc2cn(CC3CC3)c(=O)c3ccc(-c4cc(C(=O)NC5CC5)cc(F)c4C)cc23)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040077726A1,ClCCl.O=C(O)C=Cc1cccc(S(=O)(=O)Nc2ccc3ccccc3c2)c1>>O=C(Cl)C=Cc1cccc(S(=O)(=O)Nc2ccc3ccccc3c2)c1,CN(C)C=O,,,,,val
US04366315,CC1=C(C(=O)O)N2C(=O)C(NC(=O)Cc3ccccc3)[C@H]2S(=O)C1.C[Si](C)(C)NC(=O)N[Si](C)(C)C.O=C1c2ccccc2C(=O)N1Br>>C[Si](C)(C)OC(=O)C1=C(CBr)CS(=O)[C@@H]2C(NC(=O)Cc3ccccc3)C(=O)N12,,ClCCCl,,CS(=O)(=O)O,,val
US20160031865A1,CC(C)n1nccc1C1=C(CCl)CN(C)C1.O=Cc1c(O)cccc1O>>CC(C)n1nccc1C1=C(COc2cccc(O)c2C=O)CN(C)C1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04927822,CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1N=C(c2ccccc2)S[C@@H]1C(=O)OCc1ccccc1>>CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1N=C(c2ccccc2)S[C@@H]1C(=O)O,[Pd],CCO,,,,val
US20140336153A1,C=CC(=O)Cl.c1ccc2c(c1)CCNC2>>C=CC(=O)N1CCc2ccccc2C1,,ClCCl,O,CCN(CC)CC,,val
US20140275065A1,Cc1cc(C)nc(NC2CC3CCC2N3C(=O)OC(C)(C)C)n1>>Cc1cc(C)nc(NC2CC3CCC2N3)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110130412A1,CCOC(=O)[C@H](N)[C@H](O)C(=O)OCC.COc1ncnc2c(C=O)cn(COCc3ccccc3)c12>>CCOC(=O)[C@@H](O)[C@@H](NCc1cn(COCc2ccccc2)c2c(OC)ncnc12)C(=O)OCC,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20100016352A1,COC(=O)CC(=O)c1ccc(Cl)cc1.Oc1cc(O)cc(O)c1>>O=c1cc(-c2ccc(Cl)cc2)oc2cc(O)cc(O)c12,,CCOC(C)=O,,,,val
US20100217005A1,FC(F)(F)Oc1ccc(OC2CCN(c3ccc(OCc4ccccc4)cc3)CC2)cc1>>Oc1ccc(N2CCC(Oc3ccc(OC(F)(F)F)cc3)CC2)cc1,[Pd],CCO,,[H][H],,val
US05084572,CC(C)N1CC2CNCC(C2)C1.COc1ccc(C(=O)Cl)cc1OC>>COc1ccc(C(=O)N2CC3CC(C2)CN(C(C)C)C3)cc1OC,,ClCCl,,O,[Na+].[OH-],val
US20040171881A1,CCCCOC(=O)c1ccc2ccn(CCCC)c2c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCCCOC(=O)c1ccc2c(C(=O)C(F)(F)F)cn(CCCC)c2c1,,ClCCl,,O=C([O-])O.[Na+],,val
US04033996,C=[N+]=[N-].CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O>>CCCCCC(O)CCCN(CCCCCCC(=O)OC)S(C)(=O)=O,,CCOCC,,CC(=O)O,,val
US20100009975A1,CC(C)(C)OC(=O)N(CCO)CC(=O)N1CCSc2ccc([N+](=O)[O-])cc21>>CC(C)(C)OC(=O)N(CCO)CCN1CCSc2ccc([N+](=O)[O-])cc21,,C1CCOC1,CCOC(C)=O,B,,val
US20020193596A1,CCCCO.CSCC[C@H](NC(=O)c1ccc(C=Cc2cccnc2)cc1-c1ccccc1C)C(=O)O>>CCCCOC(=O)[C@H](CCSC)NC(=O)c1ccc(C=Cc2cccnc2)cc1-c1ccccc1C,O=S(=O)(O)O,CCCCO,,,,val
US04123542,CC1(CCc2ccc(Cl)cc2)CO1.Sc1ccccc1Cl>>CC(O)(CCc1ccc(Cl)cc1)CSc1ccccc1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05859007,CC(C)N(C(=O)CNc1ccccc1Nc1ccccc1)c1ccc(C(F)(F)F)cc1.O=C(Cl)CC(=O)Cl>>CC(C)N(C(=O)CN1C(=O)CC(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(F)(F)F)cc1,,C1CCOC1,,,,val
US20160009683A1,CCOC(=O)C(F)(F)c1ccc(Cl)cc1OCC>>CCOc1cc(Cl)ccc1C(F)(F)C(=O)O,,C1CCOC1,O,CO,[Li+].[OH-],val
US08716484B1,Brc1ccc(N(c2ccc(-c3ccccc3)cc2)c2ccc(-c3ccccc3)cc2)cc1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC1(C)OB(c2ccc(N(c3ccc(-c4ccccc4)cc3)c3ccc(-c4ccccc4)cc3)cc2)OC1(C)C,,C1COCCO1,O,ClCCl,CC(=O)[O-].[K+],val
US20050267095A1,CCN(CC)CCCCl.CN(C)CC1(c2ccc(O)cc2)CCOCC1>>CCN(CC)CCCOc1ccc(C2(CN(C)C)CCOCC2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110230464A1,CCn1c(C=O)nc2c(N3CCOCC3)nc(Cl)nc21.CN(C1CNC1)C(C)(C)C(N)=O>>CCn1c(CN2CC(N(C)C(C)(C)C(N)=O)C2)nc2c(N3CCOCC3)nc(Cl)nc21,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070225332A1,CC(C)Oc1ccc(O)cc1.O=Cc1cc([N+](=O)[O-])cs1>>CC(C)Oc1ccc(Oc2ccsc2C=O)cc1,,CS(C)=O,,O,[H-].[Na+],val
US05025015,CN(C(=O)CCl)c1ccc(Cl)cc1C(=O)c1ccccc1Cl.Sc1ncc[nH]1>>CN(C(=O)CSc1ncc[nH]1)c1ccc(Cl)cc1C(=O)c1ccccc1Cl.Cl,,CO,,,,val
US04299834,COc1ccc(C(=O)Nc2cncnc2NC(=O)c2ccc(OC)cc2OCCSC)c(OCCSC)c1>>COc1ccc(-c2nc3ncncc3[nH]2)c(OCCSC)c1,,O=P(Cl)(Cl)Cl,,,,val
US20040102634A1,COCCl.O=Cc1c[nH]c2ccccc12>>COCn1cc(C=O)c2ccccc21,,CN(C)C=O,O,[H-].[Na+],[Cl-].[NH4+],val
US20100016373A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc(CN)cc1Cl>>Cc1ccc(CNC(=O)OC(C)(C)C)cc1Cl,,CC(C)(C)O,,,,val
US20020119998A1,Nc1cc2ccccc2[nH]c1=O.O=C(Cl)OCc1ccccc1>>O=C(Nc1cc2ccccc2[nH]c1=O)OCc1ccccc1,,ClCCl,O,C1COCCO1,[Na+].[OH-],val
US20120149681A1,C=Cc1nccc(C(=O)OC)c1F.O=[O+][O-]>>COC(=O)c1ccnc(C=O)c1F,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050228017A1,BrCc1ccccc1.CC(=O)Cl.O=Cc1ccc(O)c(O)c1>>CC(=O)Oc1cc(C=O)ccc1OCc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120202832A1,Nc1ccc(Cl)c(Cl)c1.O=c1ncc2cc(F)ncc2[nH]1>>Fc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cn1,CN(C)C=O,CC(=O)N(C)C,,O=S(Cl)Cl,,val
US20150094297A1,CC(O)c1csc(-c2ccccc2)n1.COc1cc(O)c2cc(-c3cn4nc(OC)sc4n3)oc2c1>>COc1cc(OC(C)c2csc(-c3ccccc3)n2)c2cc(-c3cn4nc(OC)sc4n3)oc2c1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20090318405A1,CC(C)(C)OC(=O)N1CCC(=CC#N)CC1.CC1(C)OB(c2cn[nH]c2)OC1(C)C>>CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(B3OC(C)(C)C(C)(C)O3)cn2)CC1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20100120803A1,O=C1c2ccccc2C(=O)N1CCCCCN1CCCC1>>NCCCCCN1CCCC1,,CCO,,NN,O,val
US20120202785A1,C[C@H](NC(=O)OC(C)(C)C)c1nc2cccnc2n1-c1ccccc1>>C[C@H](N)c1nc2cccnc2n1-c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040019033A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1ccc(CN=[N+]=[N-])cn1>>CC(C)(C)OC(=O)NCc1ccc(C#N)nc1,,C1CCOC1,O,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080146614A1,COC(=O)c1nn(-c2ccc(Cl)cc2Cl)c(-c2ccc(O[Si](C)(C)C(C)(C)C)cc2)c1C.O=C1CCC(=O)N1Br>>COC(=O)c1nn(-c2ccc(Cl)cc2Cl)c(-c2ccc(O[Si](C)(C)C(C)(C)C)cc2)c1CBr,,ClCCCl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US04091115,CNC1CCc2ccccc2C(O)(c2ccccc2)C1>>CNC1C=C(c2ccccc2)c2ccccc2CC1,,C1COCCO1,,O,O=S(=O)(O)O,val
US20090163488A1,Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1O.O=[N+]([O-])c1ccc(Br)cn1>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Oc1ccc([N+](=O)[O-])nc1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US09249145B2,CC(C)(C)OC(=O)N1CCCNCC1.N#CCC(O)CCl>>CC(C)(C)OC(=O)N1CCCN(CC(O)CC#N)CC1,,CCO,,O=C([O-])O.[Na+],,val
US20150315198A1,O=Cc1ccc(SC2CCCC2)cc1>>OCc1ccc(SC2CCCC2)cc1,,CO,,[BH4-].[Na+],,val
US20080051387A1,CC(C)(C)OC(=O)N1CCc2cc(N3CCN(C4CCCC4)CC3)ccc2C1>>c1cc2c(cc1N1CCN(C3CCCC3)CC1)CCNC2,,C1COCCO1,,Cl,,val
US07399841B1,COc1nc(NNc2nc(OC)nc(OC)n2)nc(OC)n1>>COc1nc(N=Nc2nc(OC)nc(OC)n2)nc(OC)n1,,CC#N,,O=C1CCC(=O)N1Br,,val
US20060194801A1,COC(=O)c1ccc(C#CC(C)(C)C)cc1Cl>>CC(C)(C)C#Cc1ccc(C(=O)O)c(Cl)c1,,CO,,C1CCOC1,[Na+].[OH-],val
US20090253736A1,CC(C)(C)c1cc2cc(N)ncc2n1CCO.O=C(O)C1(c2ccc3c(c2)OC(F)(F)O3)CC1>>CC(C)(C)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)ncc2n1CCO,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04943591,CS(=O)(=O)Nc1ccc(/C=C\COCCCCCCBr)cc1.Cl.NCc1ccccc1>>CS(=O)(=O)Nc1ccc(/C=C\COCCCCCCNCc2ccccc2)cc1.Cl,,O,,,,val
US20080051395A1,CCO.N#CN.Nc1cccc(F)c1.O=[N+]([O-])O>>NC(=O)Nc1cccc(F)c1.O=[N+]([O-])O,,CCO,,CCOCC,,val
US20140371199A1,CN1CCN(C(=O)c2ccc(B(O)O)cc2)CC1.Clc1ccc(-c2cnc3ccc(Cl)nn23)cc1>>CN1CCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc(Cl)cc5)n4n3)cc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,Cl,O=C([O-])[O-].[K+].[K+],val
US20050244332A1,COc1cc(CC(=O)c2ccc3c(c2)C=CC(C)(C)O3)cc(OC)c1OCc1ccccc1>>COc1cc(CC(=O)c2ccc3c(c2)CCC(C)(C)O3)cc(OC)c1O,[Pd],CO,,,,val
US20030199440A1,Cc1ccccc1CN(CC(=O)OC(C)(C)C)S(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1.O=C(O)C(F)(F)F>>Cc1ccccc1CN(CC(=O)O)S(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1.O=C(O)C(F)(F)F,,Cc1ccccc1,,CCOCC,,val
US04147799,CC(C)N.OC(CCl)c1ccc2c(c1)OCO2>>CC(C)NCC(O)c1ccc2c(c1)OCO2.Cl,,CCO,,,,val
US04666510,CCC(=O)C1=C(O)CC(c2c(C)cc(C)c([N+](=O)[O-])c2C)CC1=O.CCON>>CCON=C(CC)C1=C(O)CC(c2c(C)cc(C)c([N+](=O)[O-])c2C)CC1=O,,CCO,,Cl,[Na+].[OH-],val
US04499094,CCCNCCC.O=C(O)c1cc2ccccc2c(-c2ccccc2Cl)n1>>CCCN(CCC)C(=O)c1cc2ccccc2c(-c2ccccc2Cl)n1,,ClC(Cl)Cl,,CCN(CC)CC,CCOC(=O)Cl,val
US20090281075A1,Cc1c(I)cccc1CNc1nc(NC[C@@H]2CCN(C(=O)OC(C)(C)C)C2)ncc1N.O=C(n1ccnc1)n1ccnc1>>Cc1c(I)cccc1Cn1c(=O)[nH]c2cnc(NC[C@@H]3CCN(C(=O)OC(C)(C)C)C3)nc21,,C1CCOC1,,,,val
US20160214972A1,CC(C)(C)OC(=O)CCOCCO.Oc1ccc(Br)cn1>>CC(C)(C)OC(=O)CCOCCOc1ccc(Br)cn1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150175601A1,CN1CCN(c2ccc(N)cc2)CC1.Clc1ncc2cccc(Br)c2n1>>CN1CCN(c2ccc(Nc3ncc4cccc(Br)c4n3)cc2)CC1,,CCCCO,,O=C(O)C(F)(F)F,,val
US20110178056A1,CC(C)(C)[Si](C)(C)OCc1cc(C#N)ccn1.NO>>CC(C)(C)[Si](C)(C)OCc1cc(C(=N)NO)ccn1,,CCO,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US04382934,ClCCCBr.O=C1Nc2ccccc2C1=O>>O=C1C(=O)N(CCCCl)c2ccccc21,,CCOC(C)=O,CN(C)C=O,Cl,CC(C)(C)[O-].[K+],val
US20110118208A1,ClCCN1CCOCC1.Oc1ccc(Br)cc1F>>Fc1cc(Br)ccc1OCCN1CCOCC1,,CN(C)C=O,O,Cl,[I-].[K+],val
US20100305135A1,CC1(C)O[C@@H]2C=C[C@@H]([C@H](O)CN)[C@@H]2O1>>CC1(C)O[C@@H]2CC[C@@H]([C@H](O)CN)[C@@H]2O1,[Pd],CO,,,,val
US04279908,Cc1c(Cl)cc(-c2ccc(=O)[nH]n2)cc1Cl.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>Cc1c(Cl)cc(-c2ccc(=S)[nH]n2)cc1Cl,,c1ccncc1,,,,val
US20070275952A1,CC1CN(C(=O)OC(C)(C)C)CCN1c1nccnc1OCc1ccncc1.O=C=Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CC1CN(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1c1nccnc1OCc1ccncc1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20110130412A1,COc1ncnc2c(CN(CCO)C[C@@H]3COC(C)(C)O3)cn(COCc3ccccc3)c12>>O=c1[nH]cnc2c(CN(CCO)C[C@@H](O)CO)c[nH]c12,,Cl,,,,val
US20100160323A1,O=C(Cl)C(=O)Cl.O=C(O)c1ccccc1C(F)(F)F>>O=C(Cl)c1ccccc1C(F)(F)F,CN(C)C=O,ClCCl,,,,val
US20100160302A1,O=C1C2CC3CC1CC(O)(C3)C2.c1ccccc1>>O=C1C2CC3CC1CC(c1ccccc1)(C3)C2,,c1ccccc1,,O=S(=O)(O)C(F)(F)F,,val
US20110071304A1,CCOC(=O)CCCc1ccc(N2Cc3cc(N(C)C)ccc3C2=O)cc1>>CN(C)c1ccc2c(c1)CN(c1ccc(CCCC(=O)O)cc1)C2=O,,CCO,,Cl,[Na+].[OH-],val
US05840975,Fc1cc(F)c(F)c(C(Cl)(Cl)Cl)c1F.[C]=O>>O=C(Cl)c1c(F)c(F)cc(F)c1F,Cl[Fe](Cl)Cl,O=CO,,Cl,,val
US20070219198A1,CC(=O)c1ccc(S(=O)(=O)Cl)cc1.C[C@@H]1CN(c2ccccc2C(F)(F)F)CCN1>>CC(=O)c1ccc(S(=O)(=O)N2CCN(c3ccccc3C(F)(F)F)C[C@H]2C)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040039061A1,COC1=C(OC)C(=O)C(Cc2ccc(-c3cccc(OC)c3)c(C(=O)O)c2)=C(C)C1=O.COc1ccc(N)cc1>>COC1=C(OC)C(=O)C(Cc2ccc(-c3cccc(OC)c3)c(C(=O)Nc3ccc(OC)cc3)c2)=C(C)C1=O,,ClCCl,O,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US20160152626A1,CI.O=C1CCOc2cc(O)c(O)cc21>>COc1cc2c(cc1O)C(=O)CCO2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06344483B1,CC(=O)NC(CC#CCNC(=N)CF)C(=O)O.Cl.Cl>>Cl.Cl.N=C(CF)NCC#CCC(N)C(=O)O,,c1ccncc1,,,,val
US20140275111A1,BrP(Br)Br.OCc1ccc(Br)c(F)c1F>>Fc1c(Br)ccc(CBr)c1F,,ClCCl,,,,val
US20110144110A1,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.Cc1cc(C#N)ccc1-n1cccc1C=O>>CCOC(=O)C=Cc1cccn1-c1ccc(C#N)cc1C,,Cc1ccccc1,,,,val
US20020026060A1,BrC(Br)(Br)Br.CCCCCC(C=O)c1ccc2c(c1)C(C)(C)CCC2(C)C>>CCCCCC(C=C(Br)Br)c1ccc2c(c1)C(C)(C)CCC2(C)C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20030149033A1,NC(=O)c1onc(C2CCCC2)c1[N+](=O)[O-]>>NC(=O)c1onc(C2CCCC2)c1N,[Zn],O,,[Cl-].[NH4+],,val
US20140275071A1,CC(=O)OC(C)(C)C.O=C1CCCC1>>CC(C)(C)OC(=O)CC1(O)CCCC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US04605674,COc1cc(O)c(C(C)=O)c(OC)c1.COc1ccc(C=O)cc1>>COc1ccc(C=CC(=O)c2c(O)cc(OC)cc2OC)cc1,,CCO,,O,[K+].[OH-],val
US20050165000A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1ccc(F)cc1I>>CC(C)(C)OC(=O)NCc1ccc(F)cc1I,,ClCCl,,CCN(CC)CC,,val
US20140323468A1,CC(=O)Cl.C[C@@H](N)c1cncc(Br)c1>>CC(=O)N[C@H](C)c1cncc(Br)c1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US09309263B2,CC(C)(C)OC(=O)NC1=NC(C)(c2cc([N+](=O)[O-])ccc2F)C(CCO)S(=O)(=O)C1(C)C>>CC(C)(C)OC(=O)NC1=NC2(C)c3cc([N+](=O)[O-])ccc3OCCC2S(=O)(=O)C1(C)C,,C1CCOC1,,CN(C)C=O,,val
US20120245209A1,O=S(=O)(Cl)C1CC1.O=c1[nH]c2c3occc3c(F)c(F)c2n1-c1ccc(I)cc1F>>O=c1n(-c2ccc(I)cc2F)c2c(F)c(F)c3ccoc3c2n1S(=O)(=O)C1CC1,CN(C)c1ccncc1,CCCCCC,ClCCl,CCOC(C)=O,,val
US20130131338A1,COC(=O)[C@@H](CC(C)C)N(C(=O)[C@H](NC(=O)OC(C)(C)C)C1Cc2ccccc2C1)[C@@H](C(=O)O)c1ccc(F)cc1.NCC(F)(F)F>>CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NCC(F)(F)F)c1ccc(F)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20140155413A1,COC(=O)c1cc2c(-c3ccnc(F)c3)nccc2[nH]1.Clc1ccc(OCCBr)cc1>>COC(=O)c1cc2c(-c3ccnc(F)c3)nccc2n1CCOc1ccc(Cl)cc1,,CN(C)C=O,O,[H-].[Na+],,val
US20130150342A1,C=O.CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@H]5CNC[C@@H]5CC4=O)cn3)nc2n1C1CCCCCC1>>CN1C[C@@H]2CC(=O)N(c3ccc(Nc4ncc5cc(C(=O)N(C)C)n(C6CCCCCC6)c5n4)nc3)C[C@@H]2C1,,C1CCOC1,,[Na],,val
US20090264444A1,CC(=O)c1sc(N2CCN(CCC3CC3)C2=O)nc1C.COC(OC)N(C)C.NN>>Cc1nc(N2CCN(CCC3CC3)C2=O)sc1-c1cc[nH]n1,,CN(C)C=O,,O,,val
US20140275030A1,O=c1[nH]c2cccc3c2n1C(c1ccccn1)CO3>>O=c1[nH]c2cccc3c2n1C(C1CCCCN1)CO3,,CO,,Cl,O,val
US20060217372A1,CCC(CC)CCN.NC(=O)c1ccc(Oc2ccc(C=O)cc2F)cn1>>CCC(CC)CCNCc1ccc(Oc2ccc(C(N)=O)nc2)c(F)c1,,CO,,[BH4-].[Na+],,val
US20160083366A1,CC(C)(C)[S@](N)=O.COc1nc2cc(OC(C)C)c(Cl)cc2cc1C(C)=O>>COc1nc2cc(OC(C)C)c(Cl)cc2cc1/C(C)=N/[S@](=O)C(C)(C)C,CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C,C1CCOC1,Cc1ccccc1,,,val
US20100048636A1,CC1CCC(C[C@@H](CN(C)C(=O)OCC[Si](C)(C)C)NC(=O)OC(C)(C)C)CC1>>CN(CC(N)CC1(C)CCCCC1)C(=O)OCC[Si](C)(C)C,[Pd],,,CO,[H][H],val
US20140051846A1,COC(CN)OC.O=C1N[C@H]2CS[C@@H](CCCCC(=O)Oc3ccccc3[N+](=O)[O-])[C@H]2N1>>COC(CNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21)OC,,CC#N,,CCN(CC)CC,,val
US20100056597A1,COC(=O)C(=O)C(F)(F)F.Cc1cc(=O)n(-c2ccc(C(C)C)cc2)[nH]1>>COC(=O)C(O)(c1c(C)[nH]n(-c2ccc(C(C)C)cc2)c1=O)C(F)(F)F,,ClC(Cl)Cl,,,,val
US08471035B1,Brc1ccc2c(c1)Cc1ccccc1-2.COC(Cl)Cl>>O=Cc1ccc2c(c1)Cc1cc(Br)ccc1-2,,ClCCl,ClCCl,Cl[Sn](Cl)(Cl)Cl,,val
US20090181942A1,CCOC(=O)c1cnn(CC[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3c2nc(C)c3C)c1>>COc1cccc([C@H]2O[C@H](CCn3cc(C(=O)O)cn3)c3nc(C)c(C)n3-c3ccc(Cl)cc32)c1OC,,CO,,Cl,[Na+].[OH-],val
US20120142717A1,N#CCBr.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#CC=P(c1ccccc1)(c1ccccc1)c1ccccc1,,CCOC(C)=O,,,,val
US20100298402A1,BrCCCBr.COC(=O)C(=Cc1cc(OC)cc(OC)c1)c1ccc(O)cc1>>COC(=O)C(=Cc1cc(OC)cc(OC)c1)c1ccc(OCCCBr)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20060160850A1,O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.OC1CCCCC1>>O=C(Oc1ccc([N+](=O)[O-])cc1)OC1CCCCC1,,C1CCOC1,,c1ccncc1,,val
US20060189602A1,CCCCn1nc(C(C)C)c(O)c(C2=Nc3ccc(O)cc3S(=O)(=O)N2)c1=O.NC(=O)CBr>>CCCCn1nc(C(C)C)c(O)c(C2=Nc3ccc(OCC(N)=O)cc3S(=O)(=O)N2)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130338134A1,COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(C=O)cc4c3N(C)C2=O)c1F.OCCN1CCNCC1>>COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCN(CCO)CC5)cc4c3N(C)C2=O)c1F,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130281433A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3nccc(Cl)n3)sc2c1-c1ccc(Cl)cc1.CN1CCNCC1>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3nccc(N4CCN(C)CC4)n3)sc2c1-c1ccc(Cl)cc1,,C1COCCO1,,,,val
US20050214287A1,CN1CCCC1CCN.O=Cc1cccc2ccccc12>>CN1CCCC1CCNCc1cccc2ccccc12,,ClCCl,,[Na],,val
US20030220272A1,OCC#Cc1ccc(-c2ncccn2)cc1>>O=CC#Cc1ccc(-c2ncccn2)cc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20120035196A1,COC(=O)c1cccc(-c2c(C)cc(OC[C@H]3COC(C)(C)O3)cc2C)c1C>>Cc1cc(OC[C@H]2COC(C)(C)O2)cc(C)c1-c1cccc(C(=O)O)c1C,,C1CCOC1,,CO,[Na+].[OH-],val
US05807883,CCOC(=O)CCC1(NC(=O)c2ccc3ccccc3c2)C(=O)N(c2ccccc2)c2cc(OC)ccc21>>CCOC(=O)CCC1(NC(=O)c2ccc3ccccc3c2)C(=O)N(c2ccccc2)c2cc(O)ccc21,,ClCCl,,BrB(Br)Br,,val
US20130072487A1,CCC(C)(C)NC(=O)NC(C)(C)CC.O=C(Cl)CC(=O)Cl>>CCC(C)(C)N1C(=O)CC(=O)N(C(C)(C)CC)C1=O,,ClC(Cl)Cl,,,,val
US04371736,Clc1cnc(Cl)nc1.O=[N+]([O-])c1ccc(Cl)nc1.Oc1ccccc1S>>O=[N+]([O-])c1ccc(Oc2ccccc2Sc2ncc(Cl)cn2)nc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2ccc(O)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21.CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1>>CC(C)(C)OC(=O)n1c(-c2ccc(OS(=O)(=O)c3ccc(C(C)(C)C)cc3)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21,,CC#N,,CCN(CC)CC,,val
US20130331379A1,C=CC(C)=O.CS(=O)(=O)Cl.OCCNc1nc2cc(Cl)ccc2o1>>CC(=O)CCN(CCOS(C)(=O)=O)c1nc2cc(Cl)ccc2o1,,CN(C)C=O,,CCN(CC)CC,[Na+].[OH-],val
US20090275592A1,CC(C)(C)OC(=O)N[C@H](CCOS(C)(=O)=O)Cc1ccc(C(F)(F)F)cc1.[N-]=[N+]=[N-]>>CC(C)(C)OC(=O)N[C@H](CCN=[N+]=[N-])Cc1ccc(C(F)(F)F)cc1,,CN(C)C=O,,CCOC(C)=O,O,val
US05840974,CC(O)Oc1ccc(Br)cc1.COS(=O)(=O)OC>>COCCOc1ccc(Br)cc1,,C1CCOC1,,[H-].[Na+],,val
US20080261967A1,CCOC(=O)C=CCc1cc(F)ccc1OC>>CCOC(=O)CCCc1cc(F)ccc1OC,[Pd],CCO,,,,val
US05130119,CC1(C)OCC(C(O)CNC(=O)c2ccc(S(=O)(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc2)O1>>O=C(NCC(O)C(O)CO)c1ccc(S(=O)(=O)Nc2ccc(F)c(C(F)(F)F)c2)cc1,,CO,O,,,val
US20040048899A1,CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1.O=C(O)[C@@H](O)[C@H](O)C(=O)O>>O=C(O)[C@@H](O)[C@H](O)C(=O)O.O=C1CSC(=O)N1,,O,,CC(C)=O,,val
US05968952,O=S(Cl)Cl.O=c1cc(-c2ccccc2)c2cc(C(O)c3cccc(F)c3)ccc2[nH]1>>O=c1cc(-c2ccccc2)c2cc(C(Cl)c3cccc(F)c3)ccc2[nH]1,,ClCCl,,,,val
US20090062360A1,Nc1ccc(F)c(F)c1.O=C(O)CN1C(=O)C(c2ccc(C(F)(F)F)cc2)=NC12CCCC2>>O=C(CN1C(=O)C(c2ccc(C(F)(F)F)cc2)=NC12CCCC2)Nc1ccc(F)c(F)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040209921A1,OCc1ncccc1Oc1ccccc1>>O=Cc1ncccc1Oc1ccccc1,O=[Mn]=O,ClCCl,,,,val
US20120172382A1,CCOC(=O)c1c(OCC)cc[nH]c1=O.OB(O)c1ccc(F)cc1>>CCOC(=O)c1c(OCC)ccn(-c2ccc(F)cc2)c1=O,,ClCCl,,c1ccncc1,,val
US20070185297A1,CC(C)=C1C=CC=CC1c1ccc(OCC(O)CO)cc1.O=C1CCCCC1.O=C=Nc1ccccc1>>CC(C)=C1C=CC=CC1c1ccc(OCC(O)CO)cc1.NC(=O)[O-],,CCN(CC)CC,,,,val
US04735959,CCOC(=O)c1ccc(C(C(N)=O)C(C(N)=O)c2ccccc2N2CCCCC2)cc1>>CCOC(=O)c1ccc(C(C(N)=O)C(C#N)c2ccccc2N2CCCCC2)cc1,,c1ccncc1,,N,,val
US20080119461A1,CC(C)(C)C[Mg]Cl.NS(=O)(=O)C1CCCCC1>>CC(C)(C)CS(N)(=O)=O,,CCOCC,,,,val
US20120316161A1,CCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc(Cl)cc1OC>>CCCC(C(=O)O)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc(Cl)cc1OC,,CO,,[Na+].[OH-],,val
US20060074370A1,C=C(C)C(=O)OCCOC(=O)C(=C)C>>C=C(C)C(=O)OCCO,,O,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US04818756,O=S1(=O)c2ccccc2S(=O)(=O)N1CCCCBr.c1cnc(N2CCNCC2)nc1>>O=S1(=O)c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ncccn2)CC1,,CN(C)C=O,,O,,val
US20090270376A1,N#CCCO.NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(Br)(C3)C2>>N#CCCOC12CC3CC(C1)C(Nc1c(C(N)=O)cnc4[nH]ccc14)C(C3)C2,,CCN(CC)CC,,,,val
US20050009895A1,BrCc1ccccc1.COc1cc(C(=O)NCc2ccc(-c3noc(C)n3)cc2NC(=O)C(F)(F)F)cc(OC)c1C>>COc1cc(C(=O)NCc2ccc(-c3noc(C)n3)cc2NCc2ccccc2)cc(OC)c1C,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20040092556A1,COC(=O)c1ccc(CNc2cccc3cccnc23)cc1>>O=C(O)c1ccc(CNc2cccc3cccnc23)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20090022670A1,CC(C)(C)OC(=O)N1CCCC[C@H]1Cc1cn2ccc(C(F)(F)F)cc2n1>>FC(F)(F)c1ccn2cc(C[C@@H]3CCCCN3)nc2c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20050065118A1,COC(=O)Cc1ccc(Oc2cccc([N+](=O)[O-])c2)cc1>>COC(=O)Cc1ccc(Oc2cccc(N)c2)cc1,[Fe],CCO,,Cl,O,val
US20040147519A1,CC(C)(C)OC(=O)NCCc1ccccn1>>CC(C)(C)OC(=O)NCCC1CCCCN1,O=[Pt]=O,CC(=O)O,,,,val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2ccc(O)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21.Cc1ccc(S(=O)(=O)Cl)cc1F>>Cc1ccc(S(=O)(=O)Oc2ccc(-c3cc4cc(CN5CCCCC5)ccc4n3C(=O)OC(C)(C)C)c3c2CNC3=O)cc1F,,CC#N,,CCN(CC)CC,,val
US20130116250A1,CCCNC(=O)Nc1ccc(C(=O)c2ncc3ccccn23)cc1C(=O)OC>>CCCn1c(=O)[nH]c2ccc(C(=O)c3ncc4ccccn34)cc2c1=O,,CO,,[Na+].[OH-],,val
US05162588,COC(Cl)Cl.Cc1cc(C)c2c(c1)C(C)(C)CCC2(C)C>>Cc1cc2c(c(C)c1C=O)C(C)(C)CCC2(C)C,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20050137193A1,CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.Cn1nncc1C(=O)c1cc(Cl)ccc1N>>Cn1nncc1C(=O)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1,,c1ccncc1,,,,val
US06051583,Br.COc1cccc2c1C[C@@H]1NCC[C@@H]1C2>>Br.Oc1cccc2c1C[C@@H]1NCC[C@@H]1C2,,O,,,,val
US20110263648A1,O=C1C=CC(=O)C2C3C=CC(CC3)C12>>OC1C=CC(O)C2C3C=CC(CC3)C12,,CO,,[BH4-].[Na+],,val
US20030149001A1,Cc1c(Br)c(=O)n(C2CCCC2)c2nc(S(C)=O)ncc12.Nc1ccc(N2CCC(O)CC2)cn1>>Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(N4CCC(O)CC4)cn3)ncc12,,Cc1ccccc1,,,,val
US20150376160A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4sc(F)cc4C(=O)OC(C)(C)C)cc3)cc2)CC1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4sc(F)cc4C(=O)O)cc3)cc2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120040954A1,C1CNC1.COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(OCCBr)c(C)c3)nc2c1>>COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(OCCN4CCC4)c(C)c3)nc2c1,,CN(C)C=O,,,,val
US20060094767A1,C=C(C)CCc1nnnn1CC.O=C(OO)c1cccc(Cl)c1>>CCn1nnnc1CCC1(C)CO1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20040254181A1,CC(=O)C(C#N)=Cc1ccccc1.CO>>CC(=O)C(C#N)Cc1ccccc1.O,[Pd],CO,,[H][H],,val
US04686220,CC1=C(N2CCNCC2)C(=O)c2ccccc2C1=O.O=C=Nc1ccc(Cl)cc1>>CC1=C(N2CCN(C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)c2ccccc2C1=O,,C1CCOC1,,,,val
US20140228361A1,O=[N+]([O-])C1C2CN(Cc3ccccc3)CC21>>NC1C2CN(Cc3ccccc3)CC12,[Ni],CO,,NN,O,val
US20030236213A1,CC(=O)O[C@H]1[C@@H](CCCCOc2cc(C)c(NC(=O)C3OC(C)(C)OCC3(C)C)c(C)c2)OC[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(=O)O[C@H]1[C@@H](CCCCOc2cc(C)c(NC(=O)C(O)C(C)(C)CO)c(C)c2)OC[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,O,,CC(=O)O,,val
US09273028B2,CC(C)(C)OC(=O)N1CCC[C@H](Nc2ncnc3c2cnn3COCC[Si](C)(C)C)C1.Cl>>Cl.c1nc(N[C@H]2CCCNC2)c2cn[nH]c2n1,,C1COCCO1,,,,val
US05902905,O=[N+]([O-])c1cccc(S(=O)(=O)CCCl)c1>>C=CS(=O)(=O)c1cccc([N+](=O)[O-])c1,CCN(CC)CC,O,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20160039808A1,Clc1nc(Cl)c2ccncc2n1.O>>Oc1nc(Cl)nc2cnccc12,,C1CCOC1,O,Cl,[Na+].[OH-],val
US05106859,CCOC(=O)c1ccc(C)nc1.OO>>CCOC(=O)c1ccc(C)[n+]([O-])c1,,CC(=O)O,,,,val
US20130190332A1,CC(C)(C)OC(=O)NC1(c2ccc(C(=O)C(Br)c3ccccc3)cc2)CCC1.COC(=O)c1ccnc(N)c1>>COC(=O)c1ccn2c(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)nc2c1,,CCO,,,,val
US20070293567A1,CCCI.CCOC(=O)Cc1cc(OCc2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)c1>>CCCC(C(=O)OCC)c1cc(OCc2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)c1,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20160046625A1,CC(C)(O)C1CCN(Cc2ccc([N+](=O)[O-])c(N[C@H]3CC[C@@H](C(N)=O)CC3)c2)CC1>>CC(C)(O)C1CCN(Cc2ccc(N)c(N[C@H]3CC[C@@H](C(N)=O)CC3)c2)CC1,[Pd],CCO,,[H][H],,val
US20140142094A1,O=C1CSc2nc(N3CCN(c4ccccn4)CC3)ncc2N1.O=Cc1ccc([N+](=O)[O-])cc1>>O=C1Nc2cnc(N3CCN(c4ccccn4)CC3)nc2S/C1=C/c1ccc([N+](=O)[O-])cc1,,CC(=O)OC(C)=O,,CCN(CC)CC,,val
US06297235B1,Clc1cc(-c2ccccc2)c(Cl)nn1.NNC(=O)c1cnccn1>>Clc1nn2c(-c3cnccn3)nnc2cc1-c1ccccc1,,Cc1ccccc1C,,CCN(CC)CC,Cl,val
US20100004333A1,CC(C)(C)c1cccc(C(C)(C)C)c1O.N#CCC(O)C#N.O=[Se]=O>>CC(C)(C)c1cc([Se]C#N)cc(C(C)(C)C)c1O,,CS(C)=O,,O,,val
US20070276025A1,C1COCCO1.O=C1Nc2cc(Br)ccc2/C1=C1/Nc2ccccc2C1=O>>C=Cc1ccc2c(c1)NC(=O)/C2=C1\Nc2ccccc2C1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20140163031A1,CCc1cc(-c2cc(C3CC(C)(C)OC(C)(C)C3)nn2-c2ccccc2OC)ccc1C(=O)O.O=C(Cl)C(=O)Cl>>COc1ccccc1-n1nc(C2CC(C)(C)OC(C)(C)C2)cc1-c1ccc(C(=O)Cl)cc1,CN(C)C=O,ClCCl,,,,val
US20150366977A1,CC(C)NC(=O)c1cc(S(=O)(=O)Cl)cs1.NO>>CC(C)NC(=O)c1cc(S(=O)(=O)NO)cs1,,C1CCOC1,,CCOC(C)=O,O,val
US06346527B1,CCOC(=O)C1=Cc2cccc(I)c2OCC1.O=C(O)C(F)(F)F>>CCOC(=O)C1=Cc2cccc(C(F)(F)F)c2OCC1,[Cu]I,CN1CCCC1=O,,[Na],,val
US20130209400A1,CC(C)(C)OC(=O)N1CCC[C@@H](N)C1.Clc1cncc(-c2cnn3ccccc23)n1>>CC(C)(C)OC(=O)N1CCC[C@@H](Nc2cncc(-c3cnn4ccccc34)n2)C1,,CS(C)=O,,O,[Cs+].[F-],val
US20020107251A1,O=[N+]([O-])c1cccc(/C=C/c2cncc(Cl)c2)c1>>Nc1cccc(/C=C/c2cncc(Cl)c2)c1,[Fe],CO,,Cl,O=C([O-])O.[Na+],val
US20070149406A1,N.Nc1c(SC(F)(F)F)c(C(=O)O)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl>>NC(=O)c1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1SC(F)(F)F,,O,,C1COCCO1,,val
US20150031861A1,C#CCN(C(=O)OC(C)(C)C)N(CCOCCOCCOCCN=[N+]=[N-])C(=O)OC(C)(C)C.COC(=O)N1C(=O)C(Br)=C(Br)C1=O>>C#CCn1c(=O)c(Br)c(Br)c(=O)n1CCOCCOCCOCCN=[N+]=[N-],,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20050014833A1,CCOc1ccc(CC2(C(=O)OC)CCCO2)cc1>>CCOc1ccc(CC2(C(=O)O)CCCO2)cc1,,CCO,,[Na+].[OH-],,val
US05117057,C#CCBr.Cc1cc(C)cc(C(=O)N(NC(=O)c2ccccc2)C(C)(C)C)c1>>C#CCN(C(=O)c1ccccc1)N(C(=O)c1cc(C)cc(C)c1)C(C)(C)C,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20150344466A1,C#CCOCc1cccc2ccccc12.CCOC(=O)C[N+](=O)[O-]>>CCOC(=O)c1cc(COCc2cccc3ccccc23)on1,,ClC(Cl)Cl,,C1CN2CCN1CC2,,val
US20100216839A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.NC(=O)c1c(F)cccc1F>>NC(=S)c1c(F)cccc1F,,Cc1ccccc1,,,,val
US20100298290A1,CC(C)(O)CCBr.Nc1ncc(Br)cc1S(=O)(=O)Cl>>CC(C)(O)CCSc1cc(Br)cnc1N,,C1COCCO1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])[O-].[K+].[K+],val
US06180629B2,O=C1OCc2ccccc21.O=Cc1ccncc1>>O=C1OC(=Cc2ccncc2)c2ccccc21,,CO,,,,val
US20070149521A1,Clc1ncccn1.Nc1nccn2c(=S)[nH]c(-c3ccc4ccc(-c5ccccc5)nc4c3F)c12>>Nc1nccn2c(Sc3ncccn3)nc(-c3ccc4ccc(-c5ccccc5)nc4c3F)c12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100048610A1,CON(C)C(=O)c1ccc(OC(C)C)c(F)c1.C[Mg]Br>>CC(=O)c1ccc(OC(C)C)c(F)c1,,C1CCOC1,,Cl,O,val
US20160096827A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(-c3ncnc(Nc4ccc(N5CCN(C6COC6)CC5)cc4)n3)cc2C#N)C(F)(F)C1>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1OC1CCNCC1(F)F,,ClCCl,O=C(O)C(F)(F)F,,,val
US20160244437A1,COC(=O)C(NC(=O)OC(C)(C)C)P(=O)(OC)OC.COc1ccc(C=O)cc1Br>>COC(=O)/C(=C/c1ccc(OC)c(Br)c1)NC(=O)OC(C)(C)C,,CCOC(C)=O,ClCCl,C1CCC2=NCCCN2CC1,Cl,val
US20130296301A1,CNC1=N[C@H]2[C@H](O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@@H]2OC(C)=O)S1>>CNC1=N[C@@H]2C(O)[C@H](O)[C@@H](CO)O[C@@H]2S1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US06265578B1,CCCCCCI.COC(=O)C(C(=O)OC)c1ccc(Oc2ccccc2)cc1>>CCCCCCC(C(=O)OC)(C(=O)OC)c1ccc(Oc2ccccc2)cc1,,C1CCOC1,,[H-].[Na+],,val
US04028084,CC(C)=C(C#N)C(=O)NCc1ccc(Cl)c(Cl)c1.COC(OC)N(C)C>>Cc1ccn(Cc2ccc(Cl)c(Cl)c2)c(=O)c1C#N,,CCO,,C1CCOC1,,val
US04476126,COC(=O)CCCC(=O)Cl.CSC(=N)N(C)N=Cc1ccccc1>>COC(=O)CCCC(=O)N=C(SC)N(C)N=Cc1ccccc1,,ClCCl,,CCN(CC)CC,O,val
US20110166133A1,O=C1COCC(c2cccc(F)c2)N1>>Fc1cccc(C2COCCN2)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05198517,CC(=O)Oc1cc(C(=O)O)cc(OC(C)=O)c1OC(C)=O.O=C(Cl)C(=O)Cl>>CC(=O)Oc1cc(C(=O)Cl)cc(OC(C)=O)c1OC(C)=O,,ClCCl,,CN(C)C=O,,val
US04956360,CCOC(=O)Oc1cc(C=Cc2nc3c(s2)NCCCC3)ccc1OC>>COc1ccc(C=Cc2nc3c(s2)NCCCC3)cc1O,,CO,,N,,val
US20050043386A1,CC(=O)N[C@](C)(CCc1ccc(C#CCCCc2ccccc2)o1)COC(C)=O>>CC(=O)N[C@](C)(CCc1ccc(CCCCCc2ccccc2)o1)COC(C)=O,[Pd],CO,,,,val
US05716624,CC(=O)OCc1ccc(C#CC(O)c2ccc3c(c2)C(C)(C)CCC3(C)C)cc1>>CC1(C)CCC(C)(C)c2cc(C(O)C#Cc3ccc(CO)cc3)ccc21,,O,,C1CCOC1,[Na+].[OH-],val
US20100324040A1,CC(C)Oc1cc(Nc2nc(Cl)ccc2[N+](=O)[O-])n[nH]1.C[C@H](N)c1ncc(F)cn1>>CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ccc2[N+](=O)[O-])n[nH]1,,CCCCO,CCOC(C)=O,CCN(C(C)C)C(C)C,Cl,val
US20140213571A1,O=Cc1c(-c2cc(Br)ccc2O)nc2ccccn12>>OCc1c(-c2cc(Br)ccc2O)nc2ccccn12,,CO,,O,[BH4-].[Na+],val
US20120295884A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(O)c1ccc2c(Br)n[nH]c2c1>>CC(C)(C)OC(=O)n1nc(Br)c2ccc(C(=O)O)cc21,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20120309738A1,N#Cc1c(N2CCCC(C(F)(F)F)C2)ccc([N+](=O)[O-])c1N>>N#Cc1c(N2CCCC(C(F)(F)F)C2)ccc(N)c1N,[Fe],CCO,,[Cl-].[NH4+],,val
US20150353581A1,COc1ccc([N+](=O)[O-])c(OC)c1F>>COc1ccc(N)c(OC)c1F,[Fe],CCO,,O,[Cl-].[NH4+],val
US20080058320A1,Nc1ncc(Br)cn1.O=CCCl>>Brc1cnc2nccn2c1,,O=C([O-])O,[Na+],,,val
US20100331315A1,C[C@H](Nc1cncc(-c2cccc(C=O)c2F)n1)c1ccccc1.O=C1CSC(=O)N1>>C[C@H](Nc1cncc(-c2cccc(C=C3SC(=O)NC3=O)c2F)n1)c1ccccc1,,CCO,,C1CCNCC1,,val
US20030078260A1,O=C(CBr)c1ccc(Br)cc1.O=S(=O)(Cl)c1ccccc1>>O=C(CS(=O)(=O)c1ccccc1)c1ccc(Br)cc1,[Zn],C1CCOC1,O,,,val
US05736487,Fc1ccc2sc(CBr)nc2c1.O=[N+]([O-])c1ccc(O)cc1>>O=[N+]([O-])c1ccc(OCc2nc3cc(F)ccc3s2)cc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20160145304A1,CC(C)O.O=[N+]([O-])c1ccc(Cl)nc1Cl>>CC(C)Oc1nc(Cl)ccc1[N+](=O)[O-],,Cc1ccccc1,,[H-].[Na+],,val
US20050244332A1,COC(=O)CCC(=O)c1ccc(CO)cc1>>COC(=O)CCCc1ccc(CO)cc1,[Pd],CO,,,,val
US20060160817A1,CC(C)NCc1ccccc1.O=C(O)c1cnc(N2CCOCC2)nc1-c1ccccc1F>>CC(C)N(Cc1ccccc1)C(=O)c1cnc(N2CCOCC2)nc1-c1ccccc1F,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20160205935A1,CC(=O)/C(C)=N/O.CN.COc1ccc(C=O)cc1C>>COc1ccc(-c2nc(C)c(C)n2C)cc1C,[Zn],CC(=O)O,,,,val
US20070185168A1,CCOC(=O)N1CCC(O)(c2sccc2C)CC1>>Cc1ccsc1C1(O)CCNCC1,,CC(C)O,,[K+].[OH-],,val
US20050130982A1,C=O.O=c1cccccc1O.c1cnc(N2CCNCC2)nc1>>O=c1c(O)ccccc1CN1CCN(c2ncccn2)CC1,,CO,,CC(=O)O,,val
US20150315198A1,COc1nc(N)cc(C)c1C#N>>COc1nc(N)cc(C)c1CN,[Ni],CO,N,[H][H],,val
US20020072516A1,COCOc1c(C(=O)OC)c(OCCCCNC(=O)OC(C)(C)C)cc2ccccc12>>COC(=O)c1c(OCCCCN)cc2ccccc2c1O,,C1COCCO1,,Cl,,val
US20050165003A1,COc1cc(C=O)ccc1OCCc1scnc1C.NC1CCCCNC1=O>>COc1cc(CNC2CCCCNC2=O)ccc1OCCc1scnc1C,,CO,,CC(=O)O,,val
US20050026812A1,CC(C)=CCCC(C)CC=O.CC[N+](=O)[O-]>>CC(C)=CCCC(C)CC(O)C(C)[N+](=O)[O-],,ClCCl,,,,val
US20100178247A1,CC(C)(C)OC(=O)NCCCCCN(Cc1ccccn1)Cc1ccccn1>>NCCCCCN(Cc1ccccn1)Cc1ccccn1,,ClCCl,O=C(O)C(F)(F)F,,,val
US05650510,BrCc1ccccc1.CC1(C)OCC(CO)CO1>>CC1(C)OCC(COCc2ccccc2)CO1,,COCCOC,,[H-].[Na+],,val
US04560403,CCC(=O)Cl.CCOC(=O)C1CC(=O)CC(=O)C1>>CCOC(=O)C1CC(=O)C(C(=O)CC)C(=O)C1,,ClCCl,,CCN(CC)CC,,val
US04810800,NCCCc1cccs1>>NCCCc1cccs1,,CN(C)C=O,,Cl,,val
US20080275056A1,CS(=O)(=O)O.Cc1ccc(-n2nc(C3(CF)CC3)cc2NC(=O)Nc2cnc(OC3CCN(C(=O)C4(C)CC4)CC3)c3ccccc23)cc1>>CS(=O)(=O)O.Cc1ccc(-n2nc(C3(CF)CC3)cc2NC(=O)Nc2cnc(OC3CCN(C(=O)C4(C)CC4)CC3)c3ccccc23)cc1,,ClCCl,,,,val
US20100234609A1,CCc1ccc(Cc2cccc3c4c(sc23)[C@@]2(OCC4)O[C@H](COCc3ccccc3)[C@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)cc1>>CCc1ccc(Cc2cccc3c4c(sc23)[C@@]2(OCC4)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1,[Pd],CCOC(C)=O,CO,,,val
US20080171772A1,CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(C(=O)O)cc2n1Cc1ccccc1.NN>>CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(C(=O)NN)cc2n1Cc1ccccc1,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,ClCCCl,,val
US20100190763A1,CCI.COC(=O)[C@H](C)NC(=O)OC(C)(C)C>>CCN(C(=O)OC(C)(C)C)[C@@H](C)C(=O)OC,,C1CCOC1,,[H-].[Na+],,val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)O)cc1.Cc1nnc(-c2ccc(N)cc2)[nH]1>>Cc1nnc(-c2ccc(NC(=O)[C@H](Cc3ccc(-c4ccc(C(=O)NC5CCN(C(=O)OC(C)(C)C)CC5)cc4C)cc3)NC(=O)[C@@H]3CC[C@@H](CNC(=O)OC(C)(C)C)CC3)cc2)[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100316601A1,COc1c(-c2c[nH]c(C(=O)O)c2)cccc1[N+](=O)[O-]>>COc1c(N)cccc1-c1c[nH]c(C(=O)O)c1,[Pd],CCOC(C)=O,,O=C[O-].[NH4+],,val
US20080051384A1,COC(=O)c1cc2[nH]c(-c3ccc4nc(Cl)ccc4c3)cc2s1.Cc1nc(C)c(B2OC(C)(C)C(C)(C)O2)s1>>COC(=O)c1cc2[nH]c(-c3ccc4nc(-c5sc(C)nc5C)ccc4c3)cc2s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20080004271A1,COc1ccc(F)c(-c2nc(NC3CC3)nc3sc(C(N)=O)c(N)c23)c1>>NC(=O)c1sc2nc(NC3CC3)nc(-c3cc(O)ccc3F)c2c1N,,ClCCl,,BrB(Br)Br,,val
US05057513,Nc1ccccc1S.O=C(O)C=C1CCCCC1Cc1ccccc1>>O=C1CC2(CCCCC2Cc2ccccc2)Sc2ccccc2N1,,CCOC(C)=O,CN(C)C=O,,,val
US20100048561A1,BrBr.COc1cccc(C(=O)O)c1N>>COc1cc(Br)cc(C(=O)O)c1N,,ClC(Cl)Cl,,,,val
US20160015690A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccnc(Cl)c3)sc2c1-c1ccc(Cl)cc1.COc1ncccc1B1OC(C)(C)C(C)(C)O1>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccnc(-c4cccnc4OC)c3)sc2c1-c1ccc(Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20040053908A1,COC(=O)c1cc2c(Oc3ccc(Cl)c([N+](=O)[O-])c3)ccnc2cc1OC>>COc1cc2nccc(Oc3ccc(Cl)c([N+](=O)[O-])c3)c2cc1C(=O)O,,CO,,Cl,[Na+].[OH-],val
US20160229814A1,CCN.Nc1ccc(Br)nc1C(=O)O>>CCNC(=O)c1nc(Br)ccc1N,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040054179A1,CCSc1nc(-c2ccc(OC)c(OC)c2)cc2nccn12.Nc1cccc(F)c1>>COc1ccc(-c2cc3nccn3c(Nc3cccc(F)c3)n2)cc1OC,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20090215725A1,CC(C)(C)[Si](C)(C)C#CCOCC1CCC2(CC1)OCCO2>>CC(C)(C)[Si](C)(C)C#CCOCC1CCC(=O)CC1,,CC(C)=O,,Cl,[Na+].[OH-],val
US05475113,CCOC(=O)c1nc(/C=C(\C)c2cc3c(cc2C)C(C)(C)CCC3(C)C)cn1S(=O)(=O)N(C)C.CI>>CCOC(=O)c1nc(/C=C(\C)c2cc3c(cc2C)C(C)(C)CCC3(C)C)cn1C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120208827A1,Nc1cc(C(F)(F)F)ccc1NC[C@@H]1CCN(C(=O)C2CC2)C1.O=Cc1ccc(Br)cc1>>O=C(C1CC1)N1CC[C@@H](Cn2c(-c3ccc(Br)cc3)nc3cc(C(F)(F)F)ccc32)C1,[Pd],CCCCO,,,,val
US04539208,CCCCCCC(=O)C(=O)O.NC(=O)C1CC1(Cl)Cl>>CCCCC/C=C(\NC(=O)C1CC1(Cl)Cl)C(=O)O,,Cc1ccccc1,,,,val
US20100249123A1,COCCBr.O=Cc1c[nH]c2ccc(F)cc12>>COCCn1cc(C=O)c2cc(F)ccc21,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US04423058,CC(C)n1ccc(O)n1.CCCN=C=O>>CCCNC(=O)Oc1cnn(C(C)C)c1,CCN(CC)CC,,,CC(C)=O,,val
US20150284391A1,CCN(CC)C(=O)c1ccc(OC)cc1C.CN(C#N)Cc1ccccc1>>COc1ccc2c(O)nc(N(C)Cc3ccccc3)cc2c1,,C1CCOC1,,[Li]C(C)(C)C,,val
US05594154,C=C(C)CC1=C(C)C(=O)C(C)=C(C)C1=O.Nc1ccc(Cl)cc1>>C=C(C)CC1=C(C)C(=Nc2ccc(Cl)cc2)C(C)=C(C)C1=O,Cl[Ti](Cl)(Cl)Cl,ClCCCl,,c1ccncc1,,val
US20070105904A1,CCCC[Sn](CCCC)(CCCC)c1cnn(Cc2ccc(OCc3ccccc3)cc2)c1.Nc1ncccc1Br>>Nc1ncccc1-c1cnn(Cc2ccc(OCc3ccccc3)cc2)c1,[Cu]I,C1CCOC1,,CCOC(C)=O,O,val
US04213998,CCOC(=O)c1cc2cc(-c3ccc(N)cc3)ccc2o1.Cl>>CCOC(=O)c1cc2cc(-c3ccc(Cl)cc3)ccc2o1,,O,,O=N[O-].[Na+],,val
US20100081653A1,CCN(CC)CC(=O)N(CC)c1ccc(N)c([N+](=O)[O-])c1>>CCN(CC)CC(=O)N(CC)c1ccc(N)c(N)c1,[Pd],CCO,,,,val
US20110028502A1,CCOC(=O)C1=CNC(=O)NC1c1ccc(F)cc1>>O=C1NC=C(C(=O)O)C(c2ccc(F)cc2)N1,,CO,O,Cl,[Na+].[OH-],val
US20070032502A1,CC(C)C[C@H]1CN(Cc2ccccc2)CCN1.O=c1[nH]c(CCl)nc2ccccc12>>CC(C)C[C@H]1CN(Cc2ccccc2)CCN1Cc1nc2ccccc2c(=O)[nH]1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05436259,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(N)(=O)=O)cc3F)c2=O)c1>>CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1,,CN(C)C=O,,[H-].[Na+],,val
US20090087759A1,CC(=O)c1ccc(F)cc1.c1ccc2c(c1)[nH]c1ccccc12>>CC(=O)c1ccc(-n2c3ccccc3c3ccccc32)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150018546A1,Cc1ncnc2c1c(NCc1ccc(N(S(C)(=O)=O)S(C)(=O)=O)nc1)cc(=O)n2OCc1ccccc1>>Cc1ncnc2c1c(NCc1ccc(NS(C)(=O)=O)nc1)cc(=O)n2OCc1ccccc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20050222225A1,NC=O.Nc1ccc(C(=O)O)cc1C(=O)O>>O=C(O)c1ccc2nc[nH]c(=O)c2c1,,CC(C)=O,,,,val
US20070010573A1,CC[C@H](C)[C@H](N)CO.O=S1(=O)CCCO1>>CCC(C)[C@@H](CO)NCCCS(=O)(=O)O,,C1CCOC1,,,,val
US20130065905A1,Cc1nccn1-c1ccc(CO)cn1>>Cc1nccn1-c1ccc(C=O)cn1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US04997840,CN(C=O)c1ccccc1C(=O)CCl.O=C(O)c1ccccc1>>CN(C=O)c1ccccc1C(=O)COC(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20160176896A1,COC(=O)C(F)(F)OCCN(Cc1ccccc1)Cc1ccccc1>>O=C1N(Cc2ccccc2)CCOC1(F)F,[Pd],CCO,,,,val
US20100144884A1,CC(=O)OCc1ccc(O)c(F)c1.COCCOCCl>>COCCOCOc1ccc(COC(C)=O)cc1F,,C1CCOC1,CN(C)C=O,O,[H-].[Na+],val
US20090298878A1,N#Cc1cc(CON=C2CCNCC2)ccc1F.O=C(CBr)Nc1ccc(F)cc1>>N#Cc1cc(CON=C2CCN(CC(=O)Nc3ccc(F)cc3)CC2)ccc1F,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04398938,O=C(Cl)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-].O=C1CCCN1>>O=C1CCCN1C(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],,Cc1ccccc1,,CCN(CC)CC,,val
US20130274268A1,Cn1cc(-c2ccc(S(C)(=O)=O)cc2)c2ncnc(OC3CCN(C(=O)OC(C)(C)C)CC3)c21>>Cn1cc(-c2ccc(S(C)(=O)=O)cc2)c2ncnc(OC3CCNCC3)c21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020065271A1,COC(=O)CCc1ccc(C(=O)NC[C@H](NC(=O)OCc2ccccc2)C(=O)OC(C)(C)C)cc1>>COC(=O)CCc1ccc(C(=O)NC[C@H](N)C(=O)OC(C)(C)C)cc1,[Pd],CO,,CC(=O)O,[H][H],val
US04088652,O=C(Cl)C1CCCCC1.c1ccc(C23CNCC2C3)cc1>>O=C(C1CCCCC1)N1CC2CC2(c2ccccc2)C1,,O,c1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20070299057A9,CCOC(=O)C1(Cc2ccccc2)CCCN(C(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N1CCCC(CO)(Cc2ccccc2)C1,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20030176418A1,CC(C)(C)c1ccc2c(c1)NC(=O)CO2.ClCCCI>>CC(C)(C)c1ccc2c(c1)N(CCCCl)C(=O)CO2,,CCCCCCC,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100273781A1,Cc1cc(C)n(CC(=O)N2CCN(c3ncc(Cl)cc3N)CC2)n1.O=C(Cl)c1cccc(Cl)c1>>Cc1cc(C)n(CC(=O)N2CCN(c3ncc(Cl)cc3NC(=O)c3cccc(Cl)c3)CC2)n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20050043315A1,COc1ccc(-c2nc(N)ncc2-c2ccc(=O)n(C(C)C)n2)cc1>>CC(C)n1nc(-c2cnc(N)nc2-c2ccc(O)cc2)ccc1=O,,ClCCl,,O,[Na+].[OH-],val
US04435406,BrCCCBr.Oc1ccccc1O>>c1ccc2c(c1)OCCCO2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160145263A1,CCOC(=O)C(=C(C)Nc1cccc(Cl)c1F)[N+](=O)[O-].CCOC(OCC)OCC>>CCOC(=O)c1ncn(-c2cccc(Cl)c2F)c1C,[Pt],,,,,val
US20120040953A1,CC(C)(C)OC(=O)N[C@H]1CNC[C@@H]1c1cc(F)ccc1F.Clc1ncc(Br)cn1>>CC(C)(C)OC(=O)N[C@H]1CN(c2ncc(Br)cn2)C[C@@H]1c1cc(F)ccc1F,,CS(C)=O,,C1CCC2=NCCCN2CC1,,val
US20090062265A1,COC(OC)c1ncc2c(n1)NC(=O)CC2>>O=Cc1ncc2c(n1)NC(=O)CC2,,CC(C)=O,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20070244158A1,Cc1cc(F)ccc1[C@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>Cc1cc(F)ccc1[C@H]1CNCC[C@@H]1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CCOC(C)=O,,Cl,,val
US05444080,CCCCc1ncc(CC(Cc2ccccc2)C(=O)OC)n1Cc1ccccc1>>CCCCc1ncc(CC(Cc2ccccc2)C(=O)O)n1Cc1ccccc1,,CCO,O,[K+].[OH-],,val
US20150232443A1,CCOC(=O)N1C2CCC1CC(N1CCC(OC)(C(=O)OC)CC1)C2>>CCOC(=O)N1C2CCC1CC(N1CCC(OC)(C(=O)O)CC1)C2,,C1CCOC1,,Cl,[Li+].[OH-],val
US20160185779A1,CC1Cc2[nH]nc(-c3ccsc3)c2CN1C(=O)OC(C)(C)C>>CC1Cc2[nH]nc(-c3ccsc3)c2CN1,,C1COCCO1,,CCOC(C)=O,Cl,val
US20100240708A1,N#Cc1ccc(CBr)cc1.O=S(=O)(N[C@@H]1CCC[C@H]1CO)c1ccc(Cl)cc1>>N#Cc1ccc(CN([C@@H]2CCC[C@H]2CO)S(=O)(=O)c2ccc(Cl)cc2)cc1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US05607960,Brc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1.C=CC(N)=O>>NC(=O)CCN1CCC[C@@H]1Cc1c[nH]c2ccc(Br)cc12,,COCCOC,,CCN(CC)CC,,val
US20010027196A1,CS(=O)c1nc(N)nc(-n2cccn2)c1C#N.Cc1cnc(CO)c(C)c1>>Cc1cnc(COc2nc(N)nc(-n3cccn3)c2C#N)c(C)c1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20050209241A1,N.O=C(O)c1cc(S(=O)(=O)Cl)ccc1O>>NS(=O)(=O)c1ccc(O)c(C(=O)O)c1,,CC(C)=O,,,,val
US20110076291A1,CC(C)n1nc(NC(=O)OCc2ccccc2)nc1-c1nc2c(s1)CCOc1cc(C3CN(CCS(C)(=O)=O)C3)ccc1-2>>CC(C)n1nc(N)nc1-c1nc2c(s1)CCOc1cc(C3CN(CCS(C)(=O)=O)C3)ccc1-2,[Pd],,,,,val
US20120202776A1,CP(C)(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)cc1.NCCc1ccc(S(N)(=O)=O)cc1>>CP(C)(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCCc3ccc(S(N)(=O)=O)cc3)n2)cc1,,CCO,,CCN(CC)CC,,val
US20030220319A1,CSCc1cccc(Cl)c1N.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CSCc1cccc(Cl)c1NC(=O)C(F)(F)F,,ClCCl,,,,val
US20110136821A1,CN1C(=O)C2(CCN(C(=O)/C=C/c3ccccc3C(F)(F)F)CC2)c2cc(C(N)=O)ccc21>>CN1C(=O)C2(CCN(C(=O)/C=C/c3ccccc3C(F)(F)F)CC2)c2cc(C#N)ccc21,,C1COCCO1,O,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US20050096309A1,CN(C)CC(=O)O.O=C1[C@@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)CCN1C1CCN(C2CCCC2)CC1>>CN(C)CC(=O)N1CCC(N2CCC[C@H](NS(=O)(=O)c3ccc4cc(Cl)ccc4c3)C2=O)CC1,,C1CCOC1,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20110152326A1,C=C[Sn](CCCC)(CCCC)CCCC.CC(C)(c1c(F)cc(OS(=O)(=O)C(F)(F)F)cc1F)C(F)(F)F>>C=Cc1cc(F)c(C(C)(C)C(F)(F)F)c(F)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,[Cl-].[Li+],,val
US20030018016A1,COc1cc(CC(=O)OC(C)(C)C)ccc1N.Cc1ccccc1N=C=O>>COc1cc(CC(=O)OC(C)(C)C)ccc1NC(=O)Nc1ccccc1C,,ClCCl,,,,val
US20100105744A1,CSCc1cccc2cc[nH]c12.OC(c1c(F)cc(Cl)cc1F)C1CC1>>CSCc1cccc2c(C(c3c(F)cc(Cl)cc3F)C3CC3)c[nH]c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110118314A1,COc1cc(F)c(F)cc1-c1ccc(OCC2CCCN(C(=O)[C@H](CC(=O)OC(C)(C)C)N(C)C(C)=O)C2)cc1>>COc1cc(F)c(F)cc1-c1ccc(OCC2CCCN(C(=O)[C@H](CC(=O)O)N(C)C(C)=O)C2)cc1,,O=CO,,,,val
US20130079338A1,CC(=O)c1cc(F)c2c(c1)CCC(=O)N2.O=C(OO)c1cccc(Cl)c1>>CC(=O)Oc1cc(F)c2c(c1)CCC(=O)N2,,ClC(Cl)Cl,,,,val
US20100035883A1,CN(C)C(=O)c1cc(C=O)ccc1F.Nc1cccc2c1COC2=O>>CN(C)C(=O)c1cc(/C=N/c2cccc3c2COC3=O)ccc1F,,CC#N,,O=S(=O)([O-])[O-].[Mg+2],,val
US20040072820A1,COc1cccc(C2=C(OC(C)=O)c3ccc(OC)cc3CC2)c1>>COc1cccc(-c2ccc3cc(OC)ccc3c2OC(C)=O)c1,,C1COCCO1,CO,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US04159984,CC(C)=C(C(=O)OCc1ccccc1)N1C(=O)C2(C(=O)Cc3ccccc3)NC(C(=O)O)OC12.c1ccccc1>>CC(=O)C1NC2(C(=O)Cc3ccccc3)C(=O)N(C(C(=O)OCc3ccccc3)=C(C)C)C2O1,,c1ccccc1,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20120202691A1,Cc1sc(-c2ccc(Cl)cc2)nc1C1C(=O)C/C(=C\c2ccc(F)cn2)C1=O>>Cc1sc(-c2ccc(Cl)cc2)nc1C1C(=O)CC(Cc2ccc(F)cn2)C1=O,[Zn],CC(=O)O,,,,val
US20040157881A1,CC(C)(C)c1ccc(-c2nnc(-c3ccc(C(=O)O)cc3[N+](=O)[O-])o2)cc1>>CC(C)(C)c1ccc(-c2nnc(-c3ccc(C(=O)O)cc3N)o2)cc1,[Pd],C1CCOC1,,,,val
US20150239845A1,CO[Na].O=C(c1ccc(Cl)cc1)c1cc(Br)c2nc(Br)cc(Br)c2c1>>COc1cc(Br)c2cc(C(=O)c3ccc(Cl)cc3)cc(Br)c2n1,,C1CCOC1,,Cc1ccccc1,,val
US03972927,CC(C)(C)c1cc(C(=O)Cl)cc(C(C)(C)C)c1O.CCNCC>>CCN(CC)C(=O)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,,c1ccccc1,,Cl,O,val
US20040132726A1,CC(=O)c1ccsc1.COC(=O)C(=O)OC>>COC(=O)C(=O)CC(=O)c1ccsc1,,CN(C)C=O,,[H-].[Na+],,val
US20040138286A1,CN(C(=O)C(F)(F)F)C1CCN(Cc2ccccc2)CC1>>CNC1CCN(Cc2ccccc2)CC1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20120190649A1,C=C(CO)C(=O)OC.CC(C)(C)[C@@H]1CC[C@@H](Oc2ccc3cc(CN)ccc3c2)CC1>>COC(=O)C(CO)CNCc1ccc2cc(O[C@@H]3CC[C@@H](C(C)(C)C)CC3)ccc2c1,,CO,,,,val
US04722926,COc1cc(N=C=O)cc(OC)c1OC.Cl.Cl.SCCCN1CCN(CCc2ccc(Cl)cc2)CC1>>COc1cc(NC(O)=[SH]CCCN2CCN(CCc3ccc(Cl)cc3)CC2)cc(OC)c1OC.Cl.Cl,,ClCCl,,CCN(CC)CC,,val
US20150025075A1,CO.O=C(O)c1cccc(Cl)c1Br>>COC(=O)c1cccc(Cl)c1Br,,CN(C)C=O,ClCCl,O=S(Cl)Cl,,val
US20080188494A1,CCC(=O)C(C#N)CCc1ccccc1.Nc1nc[nH]n1>>CCc1nc2ncnn2c(N)c1CCc1ccccc1,,Cc1cc(C)cc(C)c1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20160046605A1,CC1(NC(=O)OC(C)(C)C)CCN(c2cccnc2NC(=O)c2nc(B3OC(C)(C)C(C)(C)O3)cnc2N)CC1.FC1(F)CN(c2ccc(C(F)(F)F)c(Cl)n2)C1>>CC1(NC(=O)OC(C)(C)C)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N4CC(F)(F)C4)ccc3C(F)(F)F)cnc2N)CC1,,C1CCOC1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20110009454A1,O=C(O)c1cc(Oc2ccccc2)ccc1F.O=S(Cl)Cl>>O=C(Cl)c1cc(Oc2ccccc2)ccc1F,,Cc1ccccc1,,,,val
US20030207868A1,CC(=O)Cl.CC(C)CCn1c(Cn2c(=O)n(C(C)C)c3ccccc32)nc2cc(CN)ccc21>>CC(=O)NCc1ccc2c(c1)nc(Cn1c(=O)n(C(C)C)c3ccccc31)n2CCC(C)C,,C1CCOC1,,,,val
US20070072911A1,COC(=O)c1ccc(O)c(N)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1ccc(O)c(NC(=O)C(F)(F)F)c1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20090137557A1,Cn1ncc(C(=O)NCCc2cccc(F)c2)c1[N+](=O)[O-]>>Cn1ncc(C(=O)NCCc2cccc(F)c2)c1N,[Zn],C1CCOC1,CC(=O)O,,,val
US20100305092A1,CCOC(=O)c1nnn(-c2ccccc2F)c1-c1ccncc1.NC(=NO)c1ccccn1>>Fc1ccccc1-n1nnc(-c2nc(-c3ccccn3)no2)c1-c1ccncc1,,ClCCl,,,,val
US20040014751A1,C=C(Cl)Cl.O=C(Cl)c1c(C(F)(F)F)cc(Cl)nc1Cl>>O=C(C=C(Cl)Cl)c1c(C(F)(F)F)cc(Cl)nc1Cl,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04202895,FC(F)(F)CI.O=c1nc(-c2ccccc2)c2cc(Cl)ccc2[nH]1>>O=c1nc(-c2ccccc2)c2cc(Cl)ccc2n1CC(F)(F)F,,CN(C)C=O,,O,[H-].[Na+],val
US20130059856A1,COC(=O)c1cnc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1-c1ccc(F)cc1>>COC(=O)c1cnc(N)n1-c1ccc(F)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120010183A1,CC(C)(C)OC(=O)OC(C)(C)C.O=C(O)c1cc(F)c(F)c(F)c1>>CC(C)(C)OC(=O)c1cc(F)c(F)c(F)c1,CN(C)c1ccncc1,CC(C)(C)O,,,,val
US20040009998A1,CCN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CNC[C@H]2c1ccc(C#N)cc1.O=C(O)c1cccc(S(=O)(=O)Cl)c1>>CCN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(S(=O)(=O)c1cccc(C(=O)O)c1)C[C@H]2c1ccc(C#N)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US06713471B1,O=[N+]([O-])c1cc(Br)ccc1SCCCCl>>Nc1cc(Br)ccc1SCCCCl,,CO,,,,val
US07659304B2,C=CCBr.COC(=O)[C@H](Cc1c(Br)[nH]c2cc(Br)c(OC)c(Br)c12)NC(C)=O>>C=CCn1c(Br)c(C[C@H](NC(C)=O)C(=O)OC)c2c(Br)c(OC)c(Br)cc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160015712A1,Nc1ccc(I)cc1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>O=[N+]([O-])c1cnc(Cl)nc1Nc1ccc(I)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20130225552A1,CSc1nc2cccnc2s1.O=[Mn](=O)(=O)[O-]>>CS(=O)(=O)c1nc2cccnc2s1,,CC(=O)O,,O,,val
US20090036492A1,CCN(CC)C(=O)Cl.O=Cc1ccc(O)c2ccccc12>>CCN(CC)C(=O)Oc1ccc(C=O)c2ccccc12,,c1ccncc1,,[Cl-].[NH4+],,val
US20130059853A1,CCN=C=O.COc1ccc(-c2cccc3c2CCC3=O)c(OCC2(CO)COC2)c1OC>>CCNC(=O)OCC1(COc2c(-c3cccc4c3CCC4=O)ccc(OC)c2OC)COC1,,ClCCl,,CCN(CC)CC,,val
US20090197871A1,C1CNCCN1.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cc(C)cc(C(=O)NCc2ccc(OC)c(-c3cccc(C=O)c3)c2)c1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cc(C)cc(C(=O)NCc2ccc(OC)c(-c3cccc(CN4CCNCC4)c3)c2)c1,,CS(C)=O,,CC(=O)O,,val
US06008362,NNC(=S)NCCc1ccccn1.O=C(CCCCl)c1ccccc1>>S=C(NCCc1ccccn1)NN=C(CCCCl)c1ccccc1,,CCO,,,,val
US06251911B1,CCCCCC(=O)OC(=O)CCCCC.Nc1n[nH]c2ncnc(Nc3cccc(Cl)c3)c12>>CCCCCC(=O)Nc1n[nH]c2ncnc(Nc3cccc(Cl)c3)c12,,ClCCl,c1ccncc1,,,val
US20100093748A1,CC(C)(C)OC(=O)NC1(c2nc3ccccc3n2C(=O)OC(C)(C)C)CCN(C(=O)OC(C)(C)C)CC1.CI>>CN(C(=O)OC(C)(C)C)C1(c2nc3ccccc3n2C(=O)OC(C)(C)C)CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US20040038969A1,Clc1cc(Cl)ncn1.Nc1ccc2cccnc2c1>>Clc1cc(Nc2ccc3cccnc3c2)ncn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120316161A1,CCCI.COC(=O)Cc1c(C)nc2c(nc(C)n2C)c1-c1ccc(C)cc1>>CCCC(C(=O)OC)c1c(C)nc2c(nc(C)n2C)c1-c1ccc(C)cc1,,CN(C)C=O,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20120040957A1,CCI.COc1ccc2ncc(C(=O)OC[C@@H]3CC[C@@H](NCc4ccc5c(c4)OCCO5)CC3)cc2c1>>CCN(Cc1ccc2c(c1)OCCO2)[C@@H]1CC[C@@H](COC(=O)c2cnc3ccc(OC)cc3c2)CC1,O=[Ag],CN(C)C=O,,,,val
US20110311474A1,Cc1ccc(S(=O)(=O)n2ccc3nc(NNC(=O)C45CCC(NC(=O)OC(C)(C)C)(CC4)CC5)cnc32)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c2ncc2nnc(C45CCC(N)(CC4)CC5)n23)cc1,,C1COCCO1,,O=S(Cl)Cl,,val
US06511974B1,O=C(Cl)c1ccc(F)cc1Br.c1ccc2c(c1)Cn1cccc1CN2>>O=C(c1ccc(F)cc1Br)N1Cc2cccn2Cc2ccccc21,,ClCCl,,CCN(CC)CC,,val
US05650428,CCOC(=O)Cc1ccc(NC(=O)C(CC)NS(=O)(=O)c2ccc(Cl)cc2)cc1>>CCC(NS(=O)(=O)c1ccc(Cl)cc1)C(=O)Nc1ccc(CC(=O)O)cc1,,CCO,,[Na+].[OH-],,val
US20100048568A1,O=C(Nn1ccc2cc(F)ccc21)c1cnc(-c2cccc(F)c2)nc1.O=S(=O)(O)Cl>>O=C(Nn1cc(S(=O)(=O)Cl)c2cc(F)ccc21)c1cnc(-c2cccc(F)c2)nc1,,CC#N,,,,val
US20090149488A1,COc1cc2c(cc1OCc1ccccc1)C1Cc3c(Cl)cc(OC)c(OS(C)(=O)=O)c3CN1CC2>>COc1cc2c(cc1O)C1Cc3c(Cl)cc(OC)c(OS(C)(=O)=O)c3CN1CC2,[Ni],,,,,val
US20090275592A1,C=CCOC(=O)Nc1cc(-c2ccc3cnccc3c2)no1.O=[N+]([O-])c1ccc(S(=O)(=O)[N@]2CC2Cc2c[nH]c3ccccc23)cc1>>C=CCOC(=O)N(C[C@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc([N+](=O)[O-])cc1)c1cc(-c2ccc3cnccc3c2)no1,,CN(C)C=O,,O,,val
US20090124616A1,BrCCCOc1cccc2ccccc12.COC(=O)c1[nH]c2cccc(-c3ccccc3C)c2c1Br>>COC(=O)c1c(Br)c2c(-c3ccccc3C)cccc2n1CCCOc1cccc2ccccc12,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100298324A1,COC(=O)c1ccc(C(=O)OC)c(N=C=S)c1.NCc1nccs1>>O=C(O)c1ccc2c(=O)n(Cc3nccs3)c(=S)[nH]c2c1,,CN(C)C=O,,Cl,[Na+].[OH-],val
US20100113462A1,C1CCNCC1.CCOC(=O)C1(NC(=O)c2ccncc2F)Cc2ccccc2C1>>CCOC(=O)C1(NC(=O)c2ccncc2N2CCCCC2)Cc2ccccc2C1,,C1COCCO1,,,,val
US20140179672A1,Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NC34CCC3CN(C(=O)OC(C)(C)C)C4)n2c1>>Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NC34CCC3CNC4)n2c1,,CCOCC,,Cl,,val
US06511974B1,Cc1cc[nH]n1.O=C(c1cnc(Cl)nc1C(F)(F)F)N1Cc2cccn2Cc2ccccc21>>Cc1ccn(-c2ncc(C(=O)N3Cc4cccn4Cc4ccccc43)c(C(F)(F)F)n2)n1,,CCCCCC,CN(C)C=O,[H][H],[H-].[Na+],val
US20070167476A1,CC(C)(C)OC(=O)NCCCNc1c(N)cnc2cc(Br)ccc12.O=C(Cl)CCl>>CC(C)(C)OC(=O)NCCCn1c(CCl)nc2cnc3cc(Br)ccc3c21,,ClCCl,,CCN(CC)CC,,val
US20060235030A1,CN(C)CCN.Cc1ccc(C(=O)NC(C)C)cc1-c1nc(S(C)=O)nc2c1CNC(=O)N2c1c(F)cccc1F>>Cc1ccc(C(=O)NC(C)C)cc1-c1nc(NCCN(C)C)nc2c1CNC(=O)N2c1c(F)cccc1F,,C1CCOC1,,,,val
US20110009421A1,Clc1ccnc(Cl)c1.Sc1ccc(Cl)cc1Cl>>Clc1ccc(Sc2cccc(Cl)n2)c(Cl)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06235355B1,C1CCOC1.O=C1CCC(c2cc(F)cc(F)c2)CC1>>O=CC1CCC(c2cc(F)cc(F)c2)CC1,,O,,CC(C)(C)[O-].[K+],,val
US20100120863A1,C[N+](=O)[O-].O=Cc1cc(F)ccc1F>>O=[N+]([O-])CC(O)c1cc(F)ccc1F,,CCOCC,CO,CC(=O)O,[Na+].[OH-],val
US20090239941A1,CC(=O)N(C)C.CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(N)=O.COC(=O)Cl.ClCCl.O>>COC(=O)Oc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(N)=O)cc1OC(=O)OC,,ClCCl,,CCN(CC)CC,,val
US20090247567A1,CNC(=O)c1ccc(N(C)C(=O)c2cc3c(s2)-c2cc(C#N)ccc2OCC3)c(Cl)c1.OO>>CNC(=O)c1ccc(N(C)C(=O)c2cc3c(s2)-c2cc(C(N)=O)ccc2OCC3)c(Cl)c1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20110190269A1,COc1cc(Br)ccc1-n1cnc(C)c1.Cc1cc(-c2ccc(N3CCOCC3)cc2)c2nc(N)nn2c1>>COc1cc(Nc2nc3c(-c4ccc(N5CCOCC5)cc4)cc(C)cn3n2)ccc1-n1cnc(C)c1,,CO,ClCCl,,,val
US20080153820A1,C1CCNC1.CCOC(=O)CCc1nc(-c2ccco2)c2sccc2n1>>O=C(CCc1nc(-c2ccco2)c2sccc2n1)N1CCCC1,,Cc1ccccc1,,C[Al](C)C,,val
US20080103183A1,N#Cc1ccc(N)c(Cl)c1.NC1(CO)Cc2ccccc2C1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>N#Cc1ccc(NC(=O)NC2(CO)Cc3ccccc3C2)c(Cl)c1,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20110118261A1,CN(C)C1CCN(c2ccc(-n3ccc(CO)cc3=O)cn2)C1.O=c1ccc(Cl)c[nH]1>>CN(C)C1CCN(c2ccc(-n3ccc(COc4ccc(Cl)cn4)cc3=O)cn2)C1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100331293A1,Cc1c(-c2ccccc2S(C)(=O)=O)nc2cc(F)cc(F)c2c1Cl.Nc1cncc(C2=CCOCC2)c1>>Cc1c(-c2ccccc2S(C)(=O)=O)nc2cc(F)cc(F)c2c1Nc1cncc(C2=CCOCC2)c1,,Cc1ccccc1,,,,val
US07868205B2,NCCN1CCOCC1.O=C(O)c1ccc2c(c1)C(=O)OC2=O>>O=C(O)c1ccc2c(c1)C(=O)N(CCN1CCOCC1)C2=O,,CC(=O)O,,,,val
US07923450B2,CCCC1(c2cccc(OC)c2)CCCC(Br)C1=O.COc1cc(NC(N)=S)ccc1-n1cnc(C)c1>>CCCC1(c2cccc(OC)c2)CCCc2sc(Nc3ccc(-n4cnc(C)c4)c(OC)c3)nc21,,CCO,,,,val
US20140163012A1,Cl.O=c1cc(-c2ccc(C(F)(F)F)cc2)ccn1-c1ccc2c3c(oc2c1)CCCNC3>>Cl.O=c1cc(-c2ccc(C(F)(F)F)cc2)ccn1-c1ccc2c3c(oc2c1)CCCNC3,,CO,,CCOCC,,val
US05807857,BrCCC1OCCO1.CCOC(=O)CC(=O)N1CCN(Cc2ccccc2)CC1>>CCOC(=O)C(CCC1OCCO1)C(=O)N1CCN(Cc2ccccc2)CC1,,CN(C)C=O,,O,[H-].[Na+],val
US20080255105A1,Nc1ccc(OC(F)(F)F)c(-c2ccc(C(=O)Nc3ccc(CN4CCS(=O)(=O)CC4)cc3)cc2)c1.O=C(Cl)C1CC1>>O=C(Nc1ccc(CN2CCS(=O)(=O)CC2)cc1)c1ccc(-c2cc(NC(=O)C3CC3)ccc2OC(F)(F)F)cc1,,ClCCl,,CN1CCOCC1,,val
US20070219230A1,Cc1c(C)n(Cc2ccccc2)c2c(NCc3ccc(F)cc3)nc(C(=O)O)cc12.Cl>>Cc1c(C)n(Cc2ccccc2)c2c(NCc3ccc(F)cc3)nc(C(=O)O)cc12.Cl,,CCOC(C)=O,,,,val
US05824689,CC(=O)Cl.COc1cccc2cc(O)cnc12>>COc1cccc2cc(OC(C)=O)cnc12,,O,,CCN(CC)CC,ClCCl,val
US20100093703A1,Nc1cnc(Br)cn1.O=C(Cl)COCCCl>>O=C(COCCCl)Nc1cnc(Br)cn1,,C1CCOC1,,CCN(CC)CC,CCOC(C)=O,val
US05432195,CC(C)(C)c1ccc2oc(C(=O)COc3ccc(C(=O)OCc4ccccc4)cc3)cc2c1>>CC(C)(C)c1ccc2oc(C(=O)COc3ccc(C(=O)O)cc3)cc2c1,,CC(=O)O,,Br,,val
US20100105747A1,Cc1ccccc1[C@H]1[C@@H]2CN(C3=NC(=O)CO3)C[C@H]2CC[C@@H]1O[C@H](COC(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>Cc1ccccc1[C@H]1[C@@H]2CN(C3=NC(=O)CO3)C[C@H]2CC[C@@H]1O[C@H](CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CCOCC,CO,[Na+].[OH-],,val
US06376515B2,C1COCCO1.CSc1ccccc1Br.O=C(O)c1ccc(B(O)O)cc1>>CCSc1ccccc1-c1ccc(C(=O)O)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US06294555B1,CC(=O)C(C)Cl.COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCNCC2)CC1>>COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(C)C(C)=O)CC2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110178060A1,CN(C)C=O.Fc1ccc(Br)nc1>>O=Cc1ccc(F)cn1,,Cc1ccccc1,,[Li]CCCC,[Cl-].[NH4+],val
US05447925,C=CCOC(=O)Cl.COC(=O)[C@@H]1CC(O)CN1>>C=CCOC(=O)N1C[C@H](O)C[C@H]1C(=O)OC,,C1CCOC1,O,Cl,[Na+].[OH-],val
US04874773,CC(=O)CC(=O)NC1CC1.O=Cc1ccccc1[N+](=O)[O-]>>O=C(C=Cc1ccccc1[N+](=O)[O-])CC(=O)NC1CC1,,c1ccccc1,,C1CCNCC1,CC(=O)O,val
US20090093484A1,Cc1cc(OC/C=C(\c2ccccc2)c2ccc(C#CCN3CCOCC3)cc2)ccc1OCC(=O)O.OC/C=C(\c1ccc(I)cc1)c1ccc(SC(F)(F)F)cc1>>COC(=O)COc1ccc(OC/C=C(\c2ccc(I)cc2)c2ccc(SC(F)(F)F)cc2)cc1C,,C1CCOC1,Cc1ccccc1,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04367234,C1CCOC1.COc1ccc(Cl)c(C)c1C(O)C(=N)O>>COc1ccc(Cl)c(C)c1C1OC(=O)NC1=O,,Cc1ccccc1,,Cl,,val
US20100227864A1,CI.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>[C-]#[N+]C(C)S(=O)(=O)c1ccc(C)cc1,,ClCCl,,O,[Na+].[OH-],val
US04343945,Nc1nc(C(Cl)(Cl)Cl)ns1.O=C(Cl)c1ccccc1Cl>>O=C(Nc1nc(C(Cl)(Cl)Cl)ns1)c1ccccc1Cl,,Cc1ccccc1C,,,,val
US06294580B1,CC(=O)CC(=O)c1ccco1.NN>>Cc1cc(-c2ccco2)n[nH]1,,CO,,,,val
US20010046999A1,COC(C)(OC)N(C)C.NC(=S)c1ccc(SCCCCOc2cccc(C(F)(F)F)c2)nn1>>CC(=NC(=S)c1ccc(SCCCCOc2cccc(C(F)(F)F)c2)nn1)N(C)C,,Cc1ccccc1,,,,val
US05212187,CN(CCCN)CCC(c1ccc(Cl)cc1)c1ccccn1.N=C(N)Nc1nc(CSCCN)cs1.O=C(n1ccnc1)n1ccnc1>>CN(CCCNC(=O)NCCSCc1csc(NC(=N)N)n1)CCC(c1ccc(Cl)cc1)c1ccccn1,,CCOC(C)=O,CO,,,val
US20040029862A1,CC1CC2CCC(C1)C2N.O=S(=O)(Cl)c1ccc(Cl)s1>>CC1CC2CCC(C1)C2NS(=O)(=O)c1ccc(Cl)s1,,ClCCl,,c1ccncc1,,val
US20130338106A1,C1CCNC1.COC(OC)N(C)C.CSc1sc(C(C)=O)c2c1C(=O)CCC2>>CSc1sc(C(=O)/C=C/N2CCCC2)c2c1C(=O)CCC2,,ClCCl,,,,val
US20100113449A1,CN(C)C=O.CS(N)(=O)=O.O=C([O-])O.OB(O)c1ccc(C(F)(F)F)cc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)ccc1NS(C)(=O)=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O,,val
US04892578,CC1(C)CON(Cc2ccc(N)cc2Cl)C1=O.O=C1OC(=O)c2ncccc21>>CC1(C)CON(Cc2ccc(NC(=O)c3ncccc3C(=O)O)cc2Cl)C1=O,,C1CCOC1,,,,val
US20090258888A1,CC(=O)c1cc(Nc2ccc(Oc3ccnc(C(F)(F)F)c3)cc2)nc(N)n1.CCCN>>CCCNC(C)c1cc(Nc2ccc(Oc3ccnc(C(F)(F)F)c3)cc2)nc(N)n1,,C1CCOC1,CO,[BH3-]C#N.[Na+],,val
US20030105074A1,NN.O=C1OC(=O)c2cc(Br)ccc21>>O=C1N=NC(=O)c2cc(Br)ccc21,,CCO,,O,,val
US20150329533A1,CC(C)(C)n1nc(CN)cc1-c1ccc(C2CCCCC2)cc1.O=S(=O)(Cl)c1ccccc1>>CC(C)(C)n1nc(CNS(=O)(=O)c2ccccc2)cc1-c1ccc(C2CCCCC2)cc1,,ClCCl,,CCN(CC)CC,,val
US04440940,C=CCNc1cccc(CC(=O)O)c1.CC(O)C(=O)O>>C=CCNc1cccc(CC(=O)OC(C)C(=O)O)c1,,Cc1ccccc1,,Cc1ccccc1S(=O)(=O)O,,val
US20040023968A1,O=C(CCCCl)Nc1cccc(Cc2n[nH]c(=O)c3ccccc23)c1>>O=C1CCCN1c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1,,CCO,,C,C[O-].[Na+],val
US20030130270A1,Cl.[O-][n+]1ccc2cc(Br)ccc2c1>>Clc1nccc2cc(Br)ccc12,,O=P(Cl)(Cl)Cl,,,,val
US20150166573A1,CCSSCC.O=C(O)c1ccc(C(F)(F)F)nc1>>CCSc1cc(C(F)(F)F)ncc1C(=O)O,,C1CCOC1,,Cl,[Li]CCCC,val
US20150284382A1,CCOC(=O)c1cnc(Cl)cc1NC1CC(CO)C1>>CCOC(=O)c1cnc(Cl)cc1NC1CC(C=O)C1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090062539A1,C1CCOC1.CNc1nc(-c2cccc(NC(=O)c3ccc(C(=O)O)c(C)c3)c2)c2cc(OC)c(OC)cc2n1>>CNc1nc(-c2cccc(NC(=O)c3ccc(C(=O)O)c(C)c3)c2)c2cc(OC)c(OC)cc2n1.O,,C1CCOC1,,,,val
US20080242859A1,C1COCCO1.COC(=O)c1ccc(Br)cc1.ClCCl>>COCc1ccc(C(=O)OC)cc1,,ClCCl,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05561142,O=C(Cl)CCC1CCCC1.[N-]=[N+]=NCC(=O)c1ccccc1>>[N-]=[N+]=NC=C(OC(=O)CCC1CCCC1)c1ccccc1,,C1CCOC1,,O,CC(C)[N-]C(C)C.[Li+],val
US20150299189A1,COC(=O)c1cc(C2CC2)cnc1Nc1cc(-c2ccccc2)c2[nH]ccc2c1>>O=C(O)c1cc(C2CC2)cnc1Nc1cc(-c2ccccc2)c2[nH]ccc2c1,,C1CCOC1,CO,[Na+].[OH-],,val
US04965282,CCOC(=O)C1Oc2cc(C(=O)c3ccnn3-c3ccccn3)c(Cl)c(Cl)c2O1>>O=C(c1cc2c(c(Cl)c1Cl)OC(C(=O)O)O2)c1ccnn1-c1ccccn1,,C1CCOC1,O,[Li+].[OH-],,val
US20120094982A1,COc1ccc(CN2C(=O)C(Cc3ccccc3Cl)N=C(c3cnc(N)nc3)c3cc(Cl)ccc32)cc1>>Nc1ncc(C2=NC(Cc3ccccc3Cl)C(=O)Nc3ccc(Cl)cc32)cn1,,O,,CC#N,,val
US20060052606A1,CC(C)=O.O=C(NC(COCC1CCNCC1)c1ccc(F)cc1)c1ccc2c(Cl)c[nH]c2c1>>CC(C)N1CCC(COCC(NC(=O)c2ccc3c(Cl)c[nH]c3c2)c2ccc(F)cc2)CC1,,CC#N,,,,val
US20090253689A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1ccnc(N)c1>>CC(C)(C)OC(=O)NCc1ccnc(N)c1,,CO,,CCN(CC)CC,,val
US20140315901A1,N#Cc1c[nH]c2nc(Cl)cc(Cl)c12.O=S(=O)(Cl)c1ccccc1>>N#Cc1cn(S(=O)(=O)c2ccccc2)c2nc(Cl)cc(Cl)c12,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20130005707A1,CC(C)(C)OC(=O)N1CCCCC(N=Cc2ccccc2)C1>>CC(C)(C)OC(=O)N1CCCCC(N)C1,,CC(=O)O,ClCCl,,,val
US20100222398A1,N#CCc1ccc(C(F)(F)F)cc1F.[N-]=[N+]=Nc1ccc(S(N)(=O)=O)cc1>>Nc1c(-c2ccc(C(F)(F)F)cc2F)nnn1-c1ccc(S(N)(=O)=O)cc1,,CO,,C[O-].[Na+],,val
US04443451,CC(=O)C1CCOC1=O.Cc1ccccc1.Cl.Nc1nc2ccccc2s1>>CC1=C(CCCl)C(=O)C2Sc3ccccc3N2C1,,O,,O=P(Cl)(Cl)Cl,,val
US20120214802A1,C=CCO[C@@H]1C[C@H]([C@H]2OC(C)(C)N(C(=O)OCc3ccccc3)[C@H]2Cc2ccccc2)N(C(=O)OC(C)(C)C)C1>>CCCO[C@@H]1C[C@H]([C@H]2OC(C)(C)N[C@H]2Cc2ccccc2)N(C(=O)OC(C)(C)C)C1,,CCOC(C)=O,,,,val
US20100305096A1,CC(C)(C)OC(=O)N1CC(NC(=O)CCCCl)C1>>CC(C)(C)OC(=O)N1CC(N2CCCC2=O)C1,,CN(C)C=O,,[H-].[Na+],,val
US20130217680A1,O=C(Cc1ccc(-n2cnnn2)cc1)N1CC2CCC(C1)N2.O=[N+]([O-])c1ccc(CCBr)cc1>>O=C(Cc1ccc(-n2cnnn2)cc1)N1CC2CCC(C1)N2CCc1ccc([N+](=O)[O-])cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080234255A1,CC1CN(Cc2ccccc2)c2nc(Cl)ncc2N(C)C1=O.COc1cc(C(=O)NC2CCN(C)CC2)ccc1N>>COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(Cc1ccccc1)CC(C)C(=O)N2C,,CC(C)O,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20080306082A1,C[C@H]1CN(C(c2ccccc2)c2ccccc2)C[C@@H](C)N1CCCN1C(=O)c2ccccc2C1=O>>C[C@H]1CN(C(c2ccccc2)c2ccccc2)C[C@@H](C)N1CCCN,,CCO,,NN,,val
US20100261771A1,CCNC(=O)OCC(NC(=O)OC(C)(C)C)c1ccccc1C(F)(F)F.Cl>>CCNC(=O)OCC(N)c1ccccc1C(F)(F)F.Cl,,C1COCCO1,,,,val
US20080096953A1,CN.Cc1ccc2c(C=O)c[nH]c2c1>>CNCc1c[nH]c2cc(C)ccc12,,C1CCOC1,CO,CC(=O)O,[BH3-]C#N.[Na+],val
US20040259923A1,CC(=O)Nc1nc(CCc2ccc(N)cc2)cs1.CC(C)(C)OC(=O)NCCBr>>CC(=O)Nc1nc(CCc2ccc(NCCNC(=O)OC(C)(C)C)cc2)cs1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,O,val
US20090131379A1,CC(=O)O[C@H]1C[C@@H]2O[C@]2(C)[C@H](O[Si](C)(C)C(C)(C)C)C1>>CC(C)(C)[Si](C)(C)O[C@@H]1C[C@@H](O)C[C@@H]2O[C@@]21C,,CO,,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US05064947,Clc1nc(Cl)c2cnn(-c3ccccc3)c2n1.N[C@H](CO)Cc1ccccc1>>OC[C@H](Cc1ccccc1)Nc1nc(Cl)nc2c1cnn2-c1ccccc1,,CCO,,,,val
US20030078251A1,CC(=O)OCCCS(N)(=O)=O.COc1cccc([C@H]2O[C@H](CC(=O)O)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC>>COc1cccc([C@H]2O[C@H](CC(=O)NS(=O)(=O)CCCOC(C)=O)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC,CN(C)c1ccncc1,C1CCOC1,O,CN(C)C=O,O=S(Cl)Cl,val
US20090076070A1,CC(C)O.NC(=O)Cn1ccc2c(-c3noc(-c4ccc(F)c(Cl)c4)n3)cccc21>>CC(C)c1ccc(-c2nc(-c3cccc4c3ccn4CC(N)=O)no2)cc1Cl,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20010039344A1,CCOC(=O)Cc1ccc(SC)c(Cl)c1.ICC1CCCC1>>CCOC(=O)C(CC1CCCC1)c1ccc(SC)c(Cl)c1,,C1CCOC1,CN1CCCN(C)C1=O,CC(C)NC(C)C,[Li]CCCC,val
US20120108619A1,CCC(C)(C)n1cc(CO)c(Br)n1.CS(=O)(=O)Cl>>CCC(C)(C)n1cc(CCl)c(Br)n1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US04593104,CCc1cccc(C)c1N(Cn1cncn1)C(=O)CCl.Cl>>CCc1cccc(C)c1N(Cn1cncn1)C(=O)CCl.Cl,,CCOCC,ClCCl,,,val
US20140364414A1,CCOC(=O)C(=O)CBr.Nc1nccnc1N1CCOCC1>>CCOC(=O)c1cn2ccnc(N3CCOCC3)c2n1,,CN(C)C=O,,,,val
US04491586,CN(C)Cc1cccc(CCCO)c1.NCCCl>>CN(C)Cc1cccc(CCCOCCN)c1,,CN(C)C=O,,Cl,CC(C)(C)[O-].[K+],val
US05972942,CCCC[C@H]1CN(CC(F)(F)F)C(=O)CN1C(=O)OC(C)(C)C.ClCCl.N#Cc1ccc(Cn2cncc2C=O)cc1>>CCCC[C@H]1CN(CC(F)(F)F)C(=O)CN1Cc1cncn1Cc1ccc(C#N)cc1.Cl.Cl,,O=C(O)C(F)(F)F,,O=C([O-])O.[Na+],,val
US06028081,CCOC(=O)c1c(Cl)c2ccccc2n(-c2ccccc2)c1=O.Cc1ccccc1N>>CCOC(=O)c1c(Nc2ccccc2C)c2ccccc2n(-c2ccccc2)c1=O,,ClC(Cl)Cl,,,,val
US07129249B2,CCN=C=NCCCN(C)C.O=C(NC1Cc2ccccc2N(CC(O)CO)C1=O)c1cc2cc(Cl)sc2[nH]1.O=C(O)CN1C(=O)C(NC(=O)c2cc3cc(Cl)sc3[nH]2)Cc2ccccc21>>CC1(C)OCC(CN2C(=O)C(NC(=O)c3cc4cc(Cl)sc4[nH]3)Cc3ccccc32)O1,,CN(C)C=O,,On1nnc2ccccc21,,val
US04923872,CCOC(=O)C(C#N)(Cc1ccco1)c1nc(N)[nH]c(=O)c1[N+](=O)[O-]>>N#CC(Cc1ccco1)c1nc(N)[nH]c(=O)c1[N+](=O)[O-],,[Na+],[OH-],Cl,,val
US06441017B1,CC(C)(C)OC(=O)N1CC[C@H](NC(=S)Cc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)C1>>CC(C)(C)OC(=O)N1CC[C@H](NCCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)C1,,CO,,[BH4-].[Na+],,val
US20070213331A1,CCCSc1cc(C(=O)OC)cc(N[C@@H](C)CC)n1.O=BO[O-]>>CCC[S@](=O)c1cc(C(=O)OC)cc(NC(C)CC)n1,,CC(=O)O,,O,,val
US20090043130A1,C=C(C(F)(F)F)C(F)(F)F.CCCCCCCCCN>>CCCCCCCCCNCC(C(F)(F)F)C(F)(F)F,,O,,CC#N,,val
US20080269220A1,CCOC(=O)CP(=O)(OCC)OCC.O=Cc1c(F)cc(N(Cc2ccccc2)Cc2ccccc2)cc1F>>CCOC(=O)/C=C/c1c(F)cc(N(Cc2ccccc2)Cc2ccccc2)cc1F,,C1CCOC1,,O,[H-].[Na+],val
US20110147681A1,CCN(CCO)c1ccccc1.O=C1C=C(S(=O)(=O)[O-])c2ccccc2C1=O>>CCN(CCO)c1ccc(C2=CC(=O)C(=O)c3ccccc32)cc1,,CO,,O,,val
US20160000760A1,CC1(C)OB(c2cccc3c2ccn3S(C)(=O)=O)OC1(C)C.Nc1nc(Nc2cc(Cl)c(Br)c(Cl)c2)n[nH]1>>CS(=O)(=O)n1ccc2c(-c3c(Cl)cc(Nc4n[nH]c(N)n4)cc3Cl)cccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20140315888A1,Br.CNC1CN(c2nc3ncc(Br)cc3n3cnnc23)C1>>Br.CNC1CN(c2nc3ncc(Br)cc3n3cnnc23)C1,,CCO,,CC(=O)O,,val
US20090105218A1,O=C(Nc1ccccc1C(=O)O)c1cccc([N+](=O)[O-])c1>>Nc1cccc(C(=O)Nc2ccccc2C(=O)O)c1,[Pd],CO,,,,val
US20120214837A1,CCCc1nc(O)cc2cc(OC)c(OC)cc12.COc1ccc2nc(NCC(F)(F)F)c(CCl)cc2c1.Cl.ClCCl>>CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCC(F)(F)F)c2cc(OC)c(OC)cc12.Cl.Cl,,C1CCOC1,ClCCl,[Li+].[OH-],,val
US20070244132A1,CCOC(=O)CBr.Clc1ncnc2cc[nH]c12>>CCOC(=O)Cn1ccc2ncnc(Cl)c21,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US06143764,COS(=O)(=O)OC.Cc1cc(O)cc(O)c1>>COc1cc(C)cc(OC)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04370328,CNCc1ccncc1.O=C=Nc1ccccc1>>CN(Cc1ccncc1)C(=O)Nc1ccccc1,,ClC(Cl)Cl,,,,val
US20050033005A1,CCCCS(=O)(=O)Cl.NN1CCOCC1>>CCCCS(=O)(=O)NN1CCOCC1,,ClCCl,,CCN(CC)CC,,val
US20060148858A1,CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1COc1cc(C=O)n(C)n1.CCOC(=O)CP(=O)(OCC)OCC>>CCOC(=O)/C=C/c1cc(OCc2cn(-c3ccc(C(F)(F)F)cn3)nc2C(C)C)nn1C,,O,,CN(C)C=O,[H-].[Na+],val
US20120184539A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C1COCC(CF)(c2cccc(NC(=O)c3ccc(Cl)cn3)n2)N1>>O=C(Nc1cccc(C2(CF)COCC(=S)N2)n1)c1ccc(Cl)cn1,,C1CCOC1,,,,val
US20080275043A1,CC(C)(C)[SiH2]OC(C)(C)[C@@H]1CC[C@H](N2CCC(Cc3ccc(Cl)cc3Cl)C2=O)CC1>>O=C1C(Cc2ccc(Cl)cc2Cl)CCN1[C@@H]1CC[C@H](CO)CC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20150018318A1,CCN(CC)S(F)(F)F.CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1>>CCNC1=NC2C(OC(CF)C(O)C2O)S1,,ClCCl,,CCOC(C)=O,CO,val
US20070149460A1,C=O.CO.NCC(=O)N1C[C@H](NC(=O)c2ccccc2)C[C@H]1C(=O)O>>CN(C)CC(=O)N1C[C@H](NC(=O)c2ccccc2)C[C@H]1C(=O)O,,CO,,[BH3-]C#N.[Na+],,val
US20120252818A1,CCC(=O)Cl.COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(OC)c(Sc3cccc(N)c3)c(OC)n2)cc1>>CCC(=O)Nc1cccc(Sc2c(OC)nc(N(Cc3ccc(OC)cc3)Cc3ccc(OC)cc3)nc2OC)c1,,ClCCl,,CCN(CC)CC,,val
US20130005707A1,CON(C)C(=O)C1CCOCC1.Nc1nc2cccc(Br)n2n1>>Nc1nc2cccc(C(=O)C3CCOCC3)n2n1,,C1CCOC1,,[Li]CCCC,,val
US04753953,CC(C)(C)OC(=O)ON=C(C#N)c1ccccc1.C[C@@H]1CN(Cc2ccccc2)C[C@H]1N>>C[C@@H]1CN(Cc2ccccc2)C[C@H]1NC(=O)OC(C)(C)C.N,,C1COCCO1,,CCN(CC)CC,,val
US06103718,CCCO.COc1ccc(C2=NN(c3ccc(C(=O)O)cc3)C(=O)[C@H]3CC=CC[C@@H]23)cc1OC>>CCCOC(=O)c1ccc(N2N=C(c3ccc(OC)c(OC)c3)[C@@H]3CC=CC[C@@H]3C2=O)cc1,,CCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US06506747B1,CCc1cc(-c2cccnc2)n[nH]1.O=[N+]([O-])c1ccc(F)cc1>>CCc1cc(-c2cccnc2)nn1-c1ccc([N+](=O)[O-])cc1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US06245746B1,CC(C)(C)[Si](C)(C)Cl.CN(Cc1ccccc1)[C@H](CO)CCCNC(=O)OC(C)(C)C>>CN(Cc1ccccc1)[C@@H](CCCNC(=O)OC(C)(C)C)CO[Si](C)(C)C(C)(C)C,CN(C)c1ccncc1,O,,CCN(CC)CC,CN(C)C=O,val
US20160145219A1,O=C1OCCCN1Nc1cc(C#Cc2c(F)cc(F)cc2F)ccc1Cl>>O=C1OCCCN1Nc1cc(CCc2c(F)cc(F)cc2F)ccc1Cl,O=[Pt]=O,C1CCOC1,,,,val
US20100249179A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1CO.CC1(C)OB(c2ccc(O)cc2)OC1(C)C>>CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(B2OC(C)(C)C(C)(C)O2)cc1,,ClCCl,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160251339A1,COc1ccc(S(=O)(=O)Cl)cc1N1CCN(C(=O)C(F)(F)F)CC1.O=Cc1n[nH]c2cc(Cl)ccc12>>COc1ccc(S(=O)(=O)n2nc(C=O)c3ccc(Cl)cc32)cc1N1CCN(C(=O)C(F)(F)F)CC1,,ClCCl,,CCN(CC)CC,,val
US20150080393A1,Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(N3CCC4(CC3)C[C@@H](C(=O)OC(C)(C)C)N(C(=O)OCc3ccccc3)C4)nc(N)n2)C(F)(F)F)n1>>Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(N3CCC4(CC3)CN[C@H](C(=O)OC(C)(C)C)C4)nc(N)n2)C(F)(F)F)n1,[Pd],CCOC(C)=O,,,,val
US20160024044A1,CC(c1ccc(Cl)c(Cl)c1)C(N)(O)c1ccccc1.CCOC(=O)Cl>>CNC[C@H](c1ccc(Cl)c(Cl)c1)[C@@H](O)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20060122221A1,CC(C)(C)OC(=O)n1ncc2cc(Br)ccc21.Cc1c(F)cc(C(=O)NC2CC2)cc1B(O)O>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(cnn2C(=O)OC(C)(C)C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20040058978A1,CCOC(=C1C(=O)N(C(C)=O)c2ccccc21)c1ccccc1.CS(=O)(=O)Nc1ccc(N)cc1>>CS(=O)(=O)Nc1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1,,CN(C)C=O,CO,[Na+].[OH-],,val
US04133889,CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O.CCO.NC(CO)(CO)CO>>CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O.NC(CO)(CO)CO.O,,CCO,,,,val
US20130023514A1,C#CCOC.CON(C)C(=O)[C@@H]1CC[C@@H](N(Cc2ccccc2)Cc2ccccc2)CC1>>COCC#CC(=O)[C@@H]1CC[C@@H](N(Cc2ccccc2)Cc2ccccc2)CC1,,C1CCOC1,,[Li]CCCC,,val
US04259352,CCOC(=O)C(C)OS(=O)(=O)c1ccc(C)cc1.O=C([O-])Cc1ccc(NCCC2CCCCC2)cc1>>CCOC(=O)C(C)OC(=O)Cc1ccc(NCCC2CCCCC2)cc1,,O,,CCO,,val
US03950425,CS(=O)(=O)Cl.OC1CCC2=C(C1)c1ccccc1Oc1ccccc12>>CS(=O)(=O)OC1CCC2=C(C1)c1ccccc1Oc1ccccc12,,O,,c1ccncc1,,val
US20100256188A1,CC(C)(C)C(=O)Cl.Cn1c(Nc2cc(CN)ccc2Cl)nc2cc(C(=O)Nc3ccc(Br)cc3)c(OCC(F)F)cc21>>Cn1c(Nc2cc(CNC(=O)C(C)(C)C)ccc2Cl)nc2cc(C(=O)Nc3ccc(Br)cc3)c(OCC(F)F)cc21,,ClCCl,,O,,val
US04028386,CCOC(=O)CC(=O)CCC=C(C)CCC=C(C)C.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)CC(=O)CCC=C(C)CCC1OC1(C)C,,ClCCl,,O=C([O-])O.[Na+],,val
US20140336190A1,COC(=O)c1cc(-c2c(C)noc2C)cc([N+](=O)[O-])c1N>>COC(=O)c1cc(-c2c(C)noc2C)cc(N)c1N,[Pd],CCO,,,,val
US04113464,BrCC1OCCO1.CCCCCCN>>CCCCCCNCC1OCCO1,,O,,[Na+].[OH-],,val
US04698340,Cc1nc(-c2ccccc2)nc(-c2ccc(O)c([N+](=O)[O-])c2)c1C(=O)N1CCN(C)CC1>>Cc1nc(-c2ccccc2)nc(-c2ccc(O)c(N)c2)c1C(=O)N1CCN(C)CC1,[Pd],CO,,,,val
US20060194862A1,CS(=O)(=O)O[C@@H]1CCN(Cc2ccccc2)C1.[N-]=[N+]=[N-]>>[N-]=[N+]=N[C@H]1CCN(Cc2ccccc2)C1,,CN(C)C=O,,O,,val
US20100076193A1,CCOC(=O)CC(C)=O.CON=C1CNCC1CN>>CCOC(=O)/C=C(/C)NCC1CNC/C1=N\OC,,CO,,CCN(CC)CC,Cl,val
US20090099187A1,BrCCOCCBr.COc1ccc(S(=O)(=O)Nc2ccc(F)c(Cl)c2)c2c1C[C@@H](N)CC2>>COc1ccc(S(=O)(=O)Nc2ccc(F)c(Cl)c2)c2c1C[C@@H](N1CCOCC1)CC2,,Cc1ccccc1,ClCCl,CCN(C(C)C)C(C)C,,val
US20100144745A1,Cc1ccc(S(=O)(=O)OCC2(C(F)(F)F)CC2)cc1.NC(N)=S>>Cc1ccc(S(=O)(=O)O)cc1.N=C(N)SCC1(C(F)(F)F)CC1,,CCO,,,,val
US20140274930A1,CC(C)(C)[Si](OC[C@H]1O[C@H](Oc2ccc(I)cc2)[C@@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1)(c1ccccc1)c1ccccc1>>OC[C@H]1O[C@H](Oc2ccc(I)cc2)[C@@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1,,C1CCOC1,,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20040186102A1,NCCN1CCc2ccccc2C1.O=C1CCCc2ccc([N+](=O)[O-])cc21>>O=[N+]([O-])c1ccc2c(c1)C(=NCCN1CCc3ccccc3C1)CCC2,,CCOC(C)=O,Cc1ccccc1,O=C(O)C(F)(F)F,,val
US20080004330A1,CC(C)(O)CCN(Cc1ccc(Cl)cc1Cl)CC1CN(C(=O)OC(C)(C)C)C1>>CC(C)(O)CCN(Cc1ccc(Cl)cc1Cl)CC1CNC1,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20130225554A1,CC(C)(C)OC(=O)N1CCCC(CONC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)C1>>CC(C)(C)OC(=O)N1CCCC(CONC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3O)C1,[Pd],CO,,,,val
US20090143367A1,Cc1nc(Br)n2c1c(C)nc1ccc(F)cc12.OB(O)c1ccccc1C(F)(F)F>>Cc1nc(-c2ccccc2C(F)(F)F)n2c1c(C)nc1ccc(F)cc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US04440779,BrBr.CC(=O)Cc1cc2c(n1C)C(=O)c1ccc(Cl)cc1OC2.O.[Na+].[OH-]>>Cn1c(CC(=O)O)cc2c1C(=O)c1ccc(Cl)cc1OC2.[Na+].[O-]Br,,CCOCC,,,,val
US20100190782A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1nc(-c2ccc3c(c2)NCCC3)ccc1O>>COC(=O)c1nc(-c2ccc3c(c2)N(C(=O)OC(C)(C)C)CCC3)ccc1O,,C1CCOC1,CCOC(C)=O,,,val
US20060135524A1,CCNCC.COc1cccc2c(=O)c3ccc(C(=O)O)cc3oc12>>CCN(CC)C(=O)c1ccc2c(=O)c3cccc(OC)c3oc2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140155391A1,C=CCOC(=O)c1ccc(CNS(C)(=O)=O)c(OCC2CC2)c1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=CCOC(=O)c1ccc(CN(C(=O)OC(C)(C)C)S(C)(=O)=O)c(OCC2CC2)c1,CN(C)c1ccncc1,ClCCl,,,,val
US06423688B1,COC(=O)[C@@H](N)C(C(=O)O)C(C)(C)C.Cc1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)O)cc1>>Cc1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(=O)OC(C)(C)C)C(=O)O)cc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20030176418A1,CCCCCC1CC2CCC(C1)N2.COc1ccc2c(c1)N(C[C@H](C)CI)C(=O)CO2>>CCCCCC1CC2CCC(C1)N2C[C@@H](C)CN1C(=O)COc2ccc(OC)cc21,,CCCCCCC,CCOC(C)=O,,,val
US04880808,CCOC(=O)N1CCN(CCCCC(c2ccc(F)cc2)c2cccnc2)CC1C>>CC1CN(CCCCC(c2ccc(F)cc2)c2cccnc2)CCN1,,CC(C)O,,[K+].[OH-],,val
US20120182516A1,Brc1ccc2c(ccc3cc(Br)ccc32)c1.CC(C)OB(OC(C)C)OC(C)C>>Oc1ccc2c(ccc3cc(Br)ccc32)c1,,C1CCOC1,CCCCCC,Cl,[Li]CCCC,val
US20030216382A1,N#Cc1c(N)nc(-c2ccccc2)nc1-c1ccc(Cl)cc1Cl>>NCc1c(N)nc(-c2ccccc2)nc1-c1ccc(Cl)cc1Cl,,C1CCOC1,,CCOC(C)=O,O,val
US20140199263A1,N#Cc1cncc(Br)c1.S>>NC(=S)c1cncc(Br)c1,,c1ccncc1,,CCN(CC)CC,,val
US03946065,CC(=O)C1CC(C(C)=O)C(CCCl)C1C#N.O=C(OO)c1cccc(Cl)c1>>CC(=O)OC1CC(OC(C)=O)C(CCCl)C1C#N,,ClC(Cl)Cl,,,,val
US04563472,Cc1ccc(S(=O)(=O)OCC(I)=C(I)I)cc1.O=[N+]([O-])c1cc[nH]c1>>O=[N+]([O-])c1ccn(CC(I)=C(I)I)c1,,CN(C)C=O,,[Na+].[OH-],,val
US20120214802A1,Cc1csc(CN(C)C(=O)c2cccc(C(=O)N[C@@H](Cc3ccccc3)[C@H](O)[C@H]3CCCN3C(=O)OC(C)(C)C)c2)n1>>Cc1csc(CN(C)C(=O)c2cccc(C(=O)N[C@@H](Cc3ccccc3)[C@H](O)[C@H]3CCCN3)c2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110201604A1,COC(=O)c1ccc(NCC(C)C)c([N+](=O)[O-])c1>>COC(=O)c1ccc(NCC(C)C)c(N)c1,[Pd],CCOC(C)=O,CO,,,val
US20050182040A1,CC(C)(C)OC(=O)N1CCC(Nc2ccc(C(N)=O)cc2)CC1.O=C1CCC(=O)N1Cl>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(C(N)=O)cc2Cl)CC1,,CC(C)O,,,,val
US20050124656A1,O=C1c2ccccc2C(=O)N1Cc1cccs1.O=S(=O)(O)Cl>>O=C1c2ccccc2C(=O)N1Cc1ccc(S(=O)(=O)Cl)s1,,ClCCl,,,,val
US20090306016A1,BrB(Br)Br.COc1ccc(CCCCCOc2ccccc2)cc1>>Oc1ccc(CCCCCBr)cc1,,ClCCl,,,,val
US06323213B1,COC(=O)c1cc(F)c(F)c(Br)c1F.N#C[Cu]>>COC(=O)c1cc(F)c(F)c(C#N)c1F,,CN(C)C=O,,,,val
US05369121,O=C(Nc1ccc(C(F)(F)F)cc1)N1CC(c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)=N1>>O=C(Nc1ccc(C(F)(F)F)cc1)N1CC(c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)N1,Cl[Ti](Cl)(Cl)Cl,COCCOC,,[BH4-].[Na+],,val
US20070259888A1,CC(C)(C)OC(=O)N1CCC[C@@H](CO)C1.CCI>>CCOC[C@@H]1CCCN(C(=O)OC(C)(C)C)C1,,CN(C)C=O,,[H-].[Na+],,val
US20160185779A1,COC(=O)C(C)(C)Br.Oc1ccccc1>>COC(=O)C(C)(C)Oc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040204409A1,N#Cc1ccc([N+](=O)[O-])c(Cl)c1.NCCc1ccccc1>>N#Cc1ccc([N+](=O)[O-])c(NCCc2ccccc2)c1,,CCO,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20160002273A1,CC(C)(C)OC(=O)N1CCC(CCNC(=O)C(C)(C)C)CC1>>CC(C)(C)C(=O)NCCC1CCNCC1,,C1CCOC1,,Cl,,val
US20070244159A1,CCOC(=O)C(C)c1cc2cc(N)ccc2[nH]1.O=C(O)C1(c2ccc3c(c2)OCO3)CC1>>CCOC(=O)C(C)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OCO5)CC3)ccc2[nH]1,,CC#N,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040220404A1,CCOC(CO)OCC.COc1cc([N+](=O)[O-])ccc1Cl>>CCOC(COc1ccc(N)cc1OC)OCC,,CN(C)C=O,,[H-].[Na+],,val
US20100216769A1,BrCc1ccccc1.O=C(N1CCc2cc(O)c([N+](=O)[O-])cc2CC1)C(F)(F)F>>O=C(N1CCc2cc(OCc3ccccc3)c([N+](=O)[O-])cc2CC1)C(F)(F)F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020058644A1,Cc1cccc(CBr)c1.c1ccc2[nH]nnc2c1>>Cc1cccc(Cn2nnc3ccccc32)c1,,CN(C)C=O,O,[Na+].[OH-],,val
US06060038,O=[N+]([O-])c1cc(CO)cc([N+](=O)[O-])c1>>Nc1cc(CO)cc([N+](=O)[O-])c1,[Pd],CCOC(C)=O,,CCN(CC)CC,O=CO,val
US20040138301A1,Cc1cc(C=O)cc(C)c1O.N#CCC#N>>Cc1cc(C=C(C#N)C#N)cc(C)c1O,,CCO,,C1CCNCC1,,val
US20160143895A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c([C@@H]3CCCNC3)cc12.N#Cc1cccc2oc(Cl)nc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c([C@@H]3CCCN(c4nc5c(C#N)cccc5o4)C3)cc12,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20030078426A1,CN(C(=O)OC(C)(C)C)c1cc(OCCc2ccc(NC(=O)OC(C)(C)C)cc2)ccc1NC(=O)COc1ccc(CC2SC(=O)NC2=O)cc1>>Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccc(OCCc3ccc(N)cc3)cc21,,O=C(O)C(F)(F)F,,,,val
US20040072853A1,NO.O=C(Cc1cc(Cl)ccn1)c1ccc(F)cc1>>ON=C(Cc1cc(Cl)ccn1)c1ccc(F)cc1,,CO,,Cl,[Na+].[OH-],val
US20140178336A1,COC(=O)Cl.COC(=O)N[C@H](C(=O)N1[C@@H](C)CC[C@H]1c1ncc(-c2ccc3c(c2)COc2cc4c(ccc5nc([C@@H]6CC[C@H](C)N6C(=O)[C@@H](NC(=O)OC(C)(C)C)C6(C)CCOCC6)[nH]c54)cc2-3)[nH]1)C(C)C>>COC(=O)N[C@H](C(=O)N1[C@@H](C)CC[C@H]1c1ncc(-c2ccc3c(c2)COc2cc4c(ccc5nc([C@@H]6CC[C@H](C)N6C(=O)[C@@H](NC(=O)OC)C6(C)CCOCC6)[nH]c54)cc2-3)[nH]1)C(C)C,,CO,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20060094767A1,C[C@]1(CO)Cn2cc([N+](=O)[O-])nc2O1.Clc1nc2ccccc2o1>>C[C@]1(COc2nc3ccccc3o2)Cn2cc([N+](=O)[O-])nc2O1,,CN(C)C=O,,[H-].[Na+],,val
US20100120741A1,CCOC(=O)Cl.Nc1ccc(C(F)(F)F)cc1I>>CCOC(=O)Nc1ccc(C(F)(F)F)cc1I,,c1ccncc1,,,,val
US20100308322A1,Brc1ccc(-c2cc(-c3ccccn3)nc(-c3cccc(-n4c5ccccc5c5cnccc54)n3)c2)cc1.OB(O)c1ccc2ccccc2c1>>c1ccc(-c2cc(-c3ccc(-c4ccc5ccccc5c4)cc3)cc(-c3cccc(-n4c5ccccc5c5cnccc54)n3)n2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,ClC(Cl)Cl,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20160052884A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=c1cc(-c2ccc([N+](=O)[O-])cc2)[nH][nH]1>>CC(C)(C)OC(=O)n1[nH]c(=O)cc1-c1ccc([N+](=O)[O-])cc1,,ClCCl,O,CCN(CC)CC,,val
US20070106095A1,CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1cc(C)c2oc(C(=O)N(C)CC(=O)O)cc2c1>>CCC(CC)(c1ccc(OCC(O)C(C)(C)C)c(C)c1)c1cc(C)c2oc(C(=O)N(C)CC(=O)O)cc2c1,,C1CCOC1,,[BH4-].[Na+],,val
US20130274269A1,C[C@@H](N)CN(CCc1ccccc1Cl)S(=O)(=O)c1ccccc1[N+](=O)[O-].O=S(=O)(Cl)c1ccc2cnccc2c1>>C[C@H](CN(CCc1ccccc1Cl)S(=O)(=O)c1ccccc1[N+](=O)[O-])NS(=O)(=O)c1ccc2cnccc2c1,,ClCCl,,CCN(CC)CC,,val
US20140296532A1,O=C(NC(=S)NC1CCCCC1)c1ccccc1>>NC(=S)NC1CCCCC1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20110112103A1,BrCCBr.Oc1cccc(-c2ccc(Br)cc2)c1O>>Brc1ccc(-c2cccc3c2OCCO3)cc1,,CN(C)C=O,,[F-].[K+],,val
US20160115126A1,CI.Cc1c(C)n(COCC[Si](C)(C)C)c2c(C#N)cc(F)c(Cc3ccc(Cl)nc3)c12>>Cc1c(C)n(COCC[Si](C)(C)C)c2c(C#N)cc(F)c(C(C)c3ccc(Cl)nc3)c12,,C1CCOC1,CCOC(C)=O,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20130210800A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.Clc1ccc(Cl)c(I)n1>>Clc1ccc(Cl)c(-c2ccccn2)n1,,Cc1ccccc1,,,,val
US20020049187A1,C=C(C)C.CC(C)(C)C[C@H](N)C(=O)O>>CC(C)(C)C[C@H](N)C(=O)OC(C)(C)C,,C1COCCO1,CCOC(C)=O,O=S(=O)(O)O,[Na+].[OH-],val
US04164498,C=[N+]=[N-].O=C1CC(=O)N(c2ccccc2)c2cc(Cl)ccc2N1>>COC1=CC(=O)N(c2ccccc2)c2cc(Cl)ccc2N1,,CCOCC,CO,,,val
US20070155805A1,CCCCC(CCOc1ccc(OCC(=O)OCC)c(C)c1)c1oc2cc(C)ccc2c1C>>CCCCC(CCOc1ccc(OCC(=O)O)c(C)c1)c1oc2cc(C)ccc2c1C,,C1CCOC1,CO,[Na+].[OH-],,val
US06589950B1,CC1COCC(C)N1c1cccc([N+](=O)[O-])c1>>CC1COCC(C)N1c1cccc(N)c1,[Pd],CCO,,,,val
US20060264460A1,CN(C)C(=O)c1ccc2cc(C=O)n(C)c2c1.N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(Cl)c1>>CN(C)C(=O)c1ccc2cc(CNc3ccc4ncc(C#N)c(Nc5ccc(F)c(Cl)c5)c4c3)n(C)c2c1,,CCO,,[BH3-]C#N.[Na+],,val
US20050153972A1,COc1c(C=O)cc(C(C)(C)C)cc1[N+](=O)[O-].OCCO>>COc1c(C2OCCO2)cc(C(C)(C)C)cc1[N+](=O)[O-],,c1ccccc1,,,,val
US20070173488A1,CC(C)(C)OC(=O)Nc1cc([N+](=O)[O-])n[nH]1>>CC(C)(C)OC(=O)Nc1cc(N)n[nH]1,[Pd],CO,,,,val
US20080194618A1,BrCC1CCCCC1.OC(c1ccccc1)(c1ccccc1)C12CCN(CC1)C2>>OC(c1ccccc1)(c1ccccc1)C12CC[N+](CC3CCCCC3)(CC1)C2.[Br-],,CC#N,,,,val
US20040082575A1,CCOC(=O)/C=C/c1ccc(CC2c3ccc(O)cc3CCN2c2ccc(F)cc2)cc1>>O=C(O)/C=C/c1ccc(CC2c3ccc(O)cc3CCN2c2ccc(F)cc2)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20100324068A1,CO.COc1cc(Cl)c(CC(=O)O)cc1Cl>>COC(=O)Cc1cc(Cl)c(O)cc1Cl,,ClCCl,,BrB(Br)Br,,val
US05648315,CC(=O)Cl.COC(=O)c1ccc(CN)cc1S(=O)(=O)NC(C)(C)C>>COC(=O)c1ccc(CNC(C)=O)cc1S(=O)(=O)NC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20090192144A1,N#Cc1ccc(C2CO2)cc1.OCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>N#Cc1ccc(C(O)COCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20120258950A1,CCOC(=O)CC(=O)CBr.Cc1cnc(N)s1>>CCOC(=O)CC(=O)C[n+]1cc(C)sc1N.[Br-],,CC(C)=O,,,,val
US20070249670A1,COC(=O)[C@@H](N)[C@H](C)OC(C)C.Nc1cc2ccccc2cc1C(=O)O>>COC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1N)[C@@H](C)OC(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040152895A1,COc1cc([N+](=O)[O-])ccc1Cl>>Nc1ccc(Cl)c(O)c1,,Br,CC(=O)O,,,val
US20110166161A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](Nc2nc(OCCOCc3ccccc3)c(C(N)=O)cc2F)CC1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](Nc2nc(OCCO)c(C(N)=O)cc2F)CC1,[Pd],CCOC(C)=O,CO,,,val
US20040242884A1,CN.NS(=O)(=O)c1ccc(C2CO2)cc1>>CNCC(O)c1ccc(S(N)(=O)=O)cc1,,CO,,,,val
US20150057238A1,CC(C)(C)C(=O)OCI.O=C([O-])[C@H]1C[C@@H]1C(=O)c1ccc(Cl)c(Cl)c1>>CC(C)(C)C(=O)OCOC(=O)[C@H]1C[C@@H]1C(=O)c1ccc(Cl)c(Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05508293,CCCOC(=NC#N)c1cncc(NCc2ccccc2)c1.NCCc1ccccc1Cl>>N#CNC(=NCCc1ccccc1Cl)c1cncc(NCc2ccccc2)c1,,CO,,,,val
US20130156756A1,C1COCCN1.COc1cc(C=O)ccc1O>>COc1cc(CN2CCOCC2)ccc1O,,CC(=O)O,ClCCl,O=C([O-])O.[Na+],,val
US20110105462A1,Cc1ccc(S(=O)(=O)OC[C@H]2COc3ccc(C(F)(F)F)cc3O2)cc1.NCCO>>OCCNC[C@H]1COc2ccc(C(F)(F)F)cc2O1,,CC#N,,,,val
US20130150325A1,CCNC(=O)C(C)(C)Sc1ccc(/C=C(\F)c2cc(C)n(Cc3ccc(Cl)nc3)n2)cc1.CN>>CCNC(=O)C(C)(C)Sc1ccc(/C=C(\F)c2cc(C)n(Cc3ccc(NC)nc3)n2)cc1,,CCO,,,,val
US06124323,Nc1ccc(OCCBr)cc1[N+](=O)[O-].O=C(n1ccnc1)n1ccnc1>>O=C1N=c2ccc(OCCBr)cc2=N1,[Pd],C1CCOC1,,,,val
US20110129455A1,Cn1ncc(Cl)c1-n1cnc(C(=O)N[C@@H](Cc2ccc(F)c(F)c2)CN2C(=O)c3ccccc3C2=O)c1>>Cn1ncc(Cl)c1-n1cnc(C(=O)N[C@H](CN)Cc2ccc(F)c(F)c2)c1,,CO,ClCCl,NN,O,val
US20160050924A1,Cc1cc(Br)cnc1-n1ncc(C(=O)N(C)c2cccnc2)c1C.N#C[Cu]C#N>>Cc1cc(C#N)cnc1-n1ncc(C(=O)N(C)c2cccnc2)c1C,,CCOC(C)=O,c1ccncc1,,,val
US20040132727A1,CCN(CC)CCN.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCN(CC)CCNC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1,,ClC(Cl)Cl,O,CCN(CC)CC,,val
US20020115675A1,O=[N+]([O-])c1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1F.OCC1CC1>>O=[N+]([O-])c1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCC1CC1,,CN(C)C=O,O,Cl,CC(C)(C)[O-].[K+],val
US06627651B1,CCOc1ccc(C=O)cc1OCC>>CCOc1ccc(CO)cc1OCC,,O,,CO,[BH4-].[Na+],val
US20160016895A1,CSC(C)(C)[C@H](NC(=O)c1ccc(C#CC#C[C@@H]2C[C@H]2CO)cc1)C(=O)NO.OO>>CS(=O)C(C)(C)[C@H](NC(=O)c1ccc(C#CC#C[C@@H]2C[C@H]2CO)cc1)C(=O)NO,,CC#N,O,,,val
US20130261308A1,COc1cc(C(C)=O)ccc1O.ClCCCBr.Fc1ccc2c(C3CCNCC3)noc2c1>>COc1cc(C(C)=O)ccc1OCCCN1CCC(c2noc3cc(F)ccc23)CC1,,CC#N,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20160046633A1,CCOC(=O)c1ccc2c(Cl)ccnc2c1>>OCc1ccc2c(Cl)ccnc2c1,,C1CCOC1,,[BH4-].[Na+],,val
US20050020652A1,CCOC(=O)C(Cc1ccc(OCCC2CN(Cc3ccc(C(F)(F)F)cc3)C(=O)N2C)cc1)OC>>COC(Cc1ccc(OCCC2CN(Cc3ccc(C(F)(F)F)cc3)C(=O)N2C)cc1)C(=O)O,,CCO,,[Na+].[OH-],,val
US20050267149A1,COC(=O)c1ccccc1COc1cccc(CCO)c1.Oc1ccc(OCc2ccccc2)cc1>>COC(=O)c1ccccc1COc1cccc(CCOc2ccc(OCc3ccccc3)cc2)c1,,Cc1ccccc1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04960758,CN(C)C(=S)Cl.N#Cc1ccccc1C(=O)c1ccccc1O>>CN(C)C(=S)Oc1ccccc1C(=O)c1ccccc1C#N,,C1CCOC1,,[H-].[Na+],,val
US20160122335A1,COC(=O)C(C)(C)Cc1nc(-c2nc(C(=O)N3CCCC[C@@H]3C)c(-c3ccc(C(O)(C(F)(F)F)C(F)(F)F)c(Cl)c3Cl)s2)no1>>C[C@H]1CCCCN1C(=O)c1nc(-c2noc(CC(C)(C)C(=O)O)n2)sc1-c1ccc(C(O)(C(F)(F)F)C(F)(F)F)c(Cl)c1Cl,,C1CCOC1,O,[Li]O,,val
US20060046980A1,COCOc1ccc(Cc2c(C)cc(C(=O)OC)cc2C)cc1C(C)C>>COCOc1ccc(Cc2c(C)cc(C(=O)O)cc2C)cc1C(C)C,,CO,,Cl,[Na+].[OH-],val
US20080182843A1,NN.O=C(C=C(CCCOC1CCCCO1)c1ccccc1)c1cc(F)ccc1OCc1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(N1N=C(c2cc(F)ccc2OCc2ccccc2)CC1(CCCOC1CCCCO1)c1ccccc1)C(F)(F)F,,c1ccncc1,,O,,val
US20150191461A1,C[C@@H](NC(=O)OC(C)(C)C)C(=O)CCl>>C[C@@H](NC(=O)OC(C)(C)C)C(O)CCl,CC(=O)O,CO,,[BH4-].[Na+],,val
US20030060459A1,C=C[Sn](CCCC)(CCCC)CCCC.Cc1cc(Br)ccc1CO>>C=Cc1ccc(CO)c(C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,Cc1ccccc1,[F-].[K+],,val
US05831115,NCc1ccccc1.O=C(O)CCCCCCCCCc1ccccc1>>O=C(CCCCCCCCCc1ccccc1)NCc1ccccc1,CN(C)C=O,CCOC(C)=O,ClCCl,O=C(Cl)C(=O)Cl,O=C([O-])O.[Na+],val
US20090264650A1,C[Mg]Br.Cc1ccccc1CN1C(=O)CN(Cc2c(Cl)cccc2Cl)C1=O>>Cc1ccccc1CN1C(=O)N(Cc2c(Cl)cccc2Cl)CC1(C)O,,C1CCOC1,,[Cl-].[NH4+],,val
US05412066,Nc1ccc(O)cc1.O=C(c1ccc(F)cc1)c1ccc(C#Cc2ccccc2)cc1>>Nc1ccc(Oc2ccccc2C(=O)c2ccc(C#Cc3ccccc3)cc2)cc1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US05017569,O=C(O)c1cccc(O)c1O.O=S(=O)(O)O>>O=C(O)c1cc(S(=O)(=O)O)cc(O)c1O,,CCOCC,,ClCCl,,val
US20090197926A1,CCOC(=O)[C@@H]1CC[C@@H](Oc2ccc(NC(=O)C(=O)NN)c([N+](=O)[O-])c2)CC1.Fc1cc(F)c(N=C=S)cc1F>>CCOC(=O)[C@@H]1CC[C@@H](Oc2ccc(NC(=O)c3nnc(Nc4cc(F)c(F)cc4F)o3)c([N+](=O)[O-])c2)CC1,,CC(=O)N(C)C,,CCN=C=NCCCN(C)C,,val
US04435588,CNC(C)O.O=C(Cl)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-]>>CN(CCO)C(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],,C1CCOC1,,CCN(CC)CC,,val
US04654338,BrBr.O=[SH]1(c2ccccc2)C=C(c2ccccc2)N=CN1>>O=[SH]1(c2ccccc2)NC=NC(c2ccccc2)=C1Br,,ClC(Cl)Cl,,,,val
US20070054891A1,Clc1ccc([Mg]Br)cc1.O=Cc1ccc(Cl)cc1Cl>>OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1Cl,,CCOCC,,,,val
US03965113,CC(=O)Nc1cc(Cl)ccc1[N+](=O)[O-].Cc1ccc(S)cc1>>CC(=O)Nc1cc(Sc2ccc(C)cc2)ccc1[N+](=O)[O-],,O,,CN(C)C=O,[H-].[Na+],val
US04673746,COc1cc(O)c(/C(=N/OC(C)=O)c2ccccc2F)c(Cl)c1>>COc1cc(Cl)c2c(-c3ccccc3F)noc2c1,,CN(C)C=O,,[H-].[Na+],,val
US20140296246A1,Brc1ccccn1.CCOc1nc2c(C(=O)c3ccc(Cl)cn3)cc(-c3c(C)noc3C)cc2n1C(=O)OC(C)(C)C>>Cc1noc(C)c1-c1cc(C(O)(c2ccccn2)c2ccc(Cl)cn2)c2[nH]c(=O)[nH]c2c1,,C1CCOC1,CCO,Cl,[Li]CCCC,val
US20020032168A1,CCN(CC)CC.CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CNC(=O)NCCNC(C)C)nc32)[C@H](O)[C@@H]1O.O=C(Cl)c1ccccc1>>CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CNC(=O)NCCN(C(=O)c4ccccc4)C(C)C)nc32)[C@H](O)[C@@H]1O.N,,CCOC(C)=O,,,,val
US20070003539A1,Cl.N#Cc1ccccc1S(=O)(=O)N1CCSCC1>>Cl.NCc1ccccc1S(=O)(=O)N1CCSCC1,,C1CCOC1,,CSC,,val
US20060142612A1,O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCNc1ccccc1>>O=C1OCCN1c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US06087364,COC(=O)CC1NC(=O)c2ccccc21>>O=C1NC(CCO)c2ccccc21,,CO,,[BH4-].[Na+],,val
US20030199440A1,CC(C)(C)OC(=O)CN.O=C(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>CC(C)(C)OC(=O)CNC(=O)c1ccc2c(Cl)cnc(Cl)c2c1,,ClCCl,,CCN(CC)CC,Cl,val
US20150148550A1,C[Si](C)(C)Cl.O=C(O)c1ccc(C(F)(F)F)cc1O>>COC(=O)c1ccc(C(F)(F)F)cc1O,,Cc1ccccc1,,,,val
US20090312305A1,CN(C)C=O.Cc1cccc(Br)c1N(C)C>>Cc1cccc(C=O)c1N(C)C,,CCOCC,,CCCCC,[Li]C(C)(C)C,val
US20070135443A1,CC[Si](CC)(CC)OC(C[N+](=O)[O-])c1cccc(Cl)c1>>O=[N+]([O-])CC(O)c1cccc(Cl)c1,[Ni],CO,,,,val
US20020169318A1,ClCCl.N.N#Cc1ccc(CBr)c(I)c1>>Cl.N#Cc1ccc(CN)c(I)c1,,C1CCOC1,CO,,,val
US20050267105A1,CCOC(=O)c1nc2n(c(=O)c1OCc1ccccc1)CCOC2C>>CCOC(=O)c1nc2n(c(=O)c1O)CCOC2C,[Pd],CCO,CCOC(C)=O,[H][H],,val
US05631208,CCC(=O)C1=C(O)CC(c2c(C)c(C)c3c(c2C)OC(C)(C)C3)CC1=O.CCON>>CCON=C(CC)C1=C(O)CC(c2c(C)c(C)c3c(c2C)OC(C)(C)C3)CC1=O,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20090286778A1,COC(=O)c1cc(C#Cc2cccc(NC(=O)OC(C)(C)C)c2)cc([N+](=O)[O-])c1>>COC(=O)c1cc(N)cc(CCc2cccc(NC(=O)OC(C)(C)C)c2)c1,[Pd],CO,,,,val
US04545810,N#Cc1c(-c2ccccc2)c(-c2ccccc2)n[nH]c1=O.O.O=S(=O)([O-])CCBr>>N#Cc1c(-c2ccccc2)c(-c2ccccc2)nn(CCS(=O)(=O)O)c1=O.O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070191289A1,CC(C)(C)C(=O)OC[C@H]1O[C@H](Br)[C@H](OC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@@H]1OC(=O)C(C)(C)C.Oc1ccc(CCc2ccnc3[nH]nc(O)c23)cc1>>CC(C)(C)C(=O)OC[C@H]1O[C@@H](Oc2n[nH]c3nccc(CCc4ccc(O)cc4)c23)[C@H](OC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@@H]1OC(=O)C(C)(C)C,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04132719,C=C(CCCCCCC(Br)C(Br)CCCCCCCC)C(=O)O.CO>>C=C(CCCCCCC(Br)C(Br)CCCCCCCC)C(=O)OC,,CO,,FB(F)F,,val
US06458781B1,CC(C)=CCBr.CC(C)C[C@H](N)C(=O)NCCCC(c1ccc(F)cc1)c1ccc(F)cc1.Cl>>CC(C)=CCN[C@@H](CC(C)C)C(=O)NCCCC(c1ccc(F)cc1)c1ccc(F)cc1.Cl,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20050090504A1,CC(C)C(N)C(=O)N1CCC(Cc2ccc(Cl)c(Cl)c2)CC1>>CC(C)C(N)CN1CCC(Cc2ccc(Cl)c(Cl)c2)CC1,,C1CCOC1,,B,Cl,val
US20150218102A1,COC(=O)c1ccc2cc(O)ccc2n1.Fc1ccc(C(F)(F)F)cn1>>COC(=O)c1ccc2cc(Oc3ccc(C(F)(F)F)cn3)ccc2n1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20030022884A1,COc1ccc(S(=O)(=O)Nc2ccccc2/C=C/c2cc[n+]([O-])cc2)cc1.ClCCl.O=C(O)CN1CCOCC1>>COc1ccc(S(=O)(=O)N(C(=O)CN2CCOCC2)c2ccccc2/C=C/c2cc[n+]([O-])cc2)cc1.Cl,,CO,ClCCl,CCN(CC)CC,CCOC(=O)Cl,val
US04407930,CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)C(=O)c1cccc(S(=O)(=O)Cl)c1.Cc1nc2c(O)cc(N)cc2o1>>CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)C(=O)c1cccc(S(=O)(=O)Nc2cc(O)c3nc(C)oc3c2)c1,,c1ccncc1,,Cl,,val
US20110178063A1,CI.O=S(=O)(c1ccccc1)n1ccc2c(Br)ccnc21>>Cc1cc2c(Br)ccnc2n1S(=O)(=O)c1ccccc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20120178778A1,Cc1sc(-c2ccnc3[nH]ncc23)nc1C(C)(C)CNC(=O)c1ccccc1>>Cc1sc(-c2ccnc3[nH]ncc23)nc1C(C)(C)CN,,CCO,,[Na+].[OH-],,val
US20090221582A1,CC(C)(C)OC(=O)N1CCN(c2ccc(Cl)cc2)C(c2ccc(Br)cc2)C1.CN(C)C=O>>CC(C)(C)OC(=O)N1CCN(c2ccc(Cl)cc2)C(c2ccc(C=O)cc2)C1,,C1CCOC1,,[Li]C(C)(C)C,,val
US20060069087A1,CN(C)C=O.COC(=O)c1ccc(NC(=O)C(F)(F)F)c(I)c1>>COC(=O)c1ccc2[nH]c(CO)cc2c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,CCN(CC)CC,,val
US05698584,CC(C)C(=O)Cl.CSc1ccccc1>>CSc1ccc(C(=O)C(C)C)cc1,,ClC(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20030220326A1,CCOC(=O)c1ccc(C(=O)c2sc(Nc3ccc(S(N)(=O)=O)cc3)nc2N)cc1>>Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)sc1C(=O)c1ccc(C(=O)O)cc1,,CO,,Cl,[Na+].[OH-],val
US20090264440A1,COCCN(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)cc4F)c3s2)nc1)C(=O)OC(C)(C)C>>COCCNCc1ccc(-c2cc3nccc(Oc4ccc(N(C(=O)C5(C(N)=O)CC5)c5ccc(F)cc5)cc4F)c3s2)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090099205A1,CN=C=S.C[C@H](CCNC(=O)OC(C)(C)C)N1CCC(NCc2ccsc2)CC1>>CNC(=S)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)OC(C)(C)C)CC1,,ClCCl,,,,val
US20110110889A1,CCCS(=O)(=O)N(c1ccc(F)c(C(=O)OC)c1F)S(=O)(=O)CCC.Nc1cnc2c(c1)cc(I)n2S(=O)(=O)c1ccccc1>>CCCS(=O)(=O)N(c1ccc(F)c(C(=O)Nc2cnc3c(c2)cc(I)n3S(=O)(=O)c2ccccc2)c1F)S(=O)(=O)CCC,,CCOC(C)=O,Cc1ccccc1,C[Al](C)C,,val
US20130190312A1,COc1ccc(Sc2cc(C)c(-c3csc(N)n3)c(Cl)c2)cc1.O=C(Cl)c1ccncc1>>COc1ccc(Sc2cc(C)c(-c3csc(NC(=O)c4ccncc4)n3)c(Cl)c2)cc1,CN(C)c1ccncc1,,,Cl,,val
US20140235855A1,CCOP(=O)(OCC)OCC.COc1ccc2ncc(OCc3ccccc3)c(CBr)c2n1>>CCOP(=O)(Cc1c(OCc2ccccc2)cnc2ccc(OC)nc12)OCC,,Cc1ccccc1,,CCOC(C)=O,,val
US20020147219A1,OCC(CO)NC1CCN(Cc2ccccc2)CC1>>OCC(CO)NC1CCNCC1,[Pd],CO,,[H][H],,val
US20150057248A1,CC(C)S(=O)(=O)Cl.CC(CN)c1ccccc1>>CC(CNS(=O)(=O)C(C)C)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,Cl,val
US20080221180A1,C=CCN.CC(=O)Nc1nc(C)c(-c2cc(S(=O)(=O)Cl)sc2Br)s1>>C=CCNS(=O)(=O)c1cc(-c2sc(NC(C)=O)nc2C)c(Br)s1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100105700A1,CI.C[C@]12CC[C@H]3[C@@H](CNC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=O>>CN1C[C@H]2[C@@H]3CCC(=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12,,CN(C)C=O,,[H-].[Na+],,val
US20160264552A1,CC(C)(C)OC(=O)NC1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1>>NC1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1,,CCOC(C)=O,Cl,,,val
US20070004736A1,CC(=O)Cl.O=C(CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(NCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)CC1>>CC(=O)N(Cc1c[nH]cn1)C1CCN(C(=O)CCS(=O)(=O)c2ccc3cc(Cl)ccc3c2)CC1,,ClCCl,,CCN(CC)CC,,val
US20110118235A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=Cc1ccc(Br)cc1[N+](=O)[O-]>>CC1(C)OB(c2ccc(C=O)c([N+](=O)[O-])c2)OC1(C)C,,C1COCCO1,,C1CCC(P(C2CCCCC2)C2CCCCC2)CC1,CC(=O)[O-].[K+],val
US20120202856A1,CNN.COC(=N)C(C)(C)C.Cl>>CNNC(=N)C(C)(C)C.Cl,,CO,,,,val
US20100204196A1,C=CC(=O)Cl.COc1cc2c(cc1[N+](=O)[O-])CNCC2>>C=CC(=O)N1CCc2cc(OC)c([N+](=O)[O-])cc2C1,CN(C)c1ccncc1,ClCCl,O,CCN(CC)CC,,val
US20160052930A1,CCN.O=C(O)c1ccc(Nc2nccc(Cl)n2)cc1>>CCNC(=O)c1ccc(Nc2nccc(Cl)n2)cc1,,ClCCl,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100210647A1,C1COCCN1.CS(=O)(=O)Cc1cc(NC2CCCC2)c2[nH]c(C3=N[C@H](CCI)CS3)cc2c1>>CS(=O)(=O)Cc1cc(NC2CCCC2)c2[nH]c(C3=N[C@H](CCN4CCOCC4)CS3)cc2c1,,CN(C)C=O,,,,val
US05472964,Cc1nc2cccnc2s1.O=C(OO)c1cccc(Cl)c1>>Cc1sc2ncccc2[n+]1[O-],,ClCCl,,[Na+].[OH-],,val
US20100137317A1,CC1(C)OC(=O)C(c2ccc(OCc3ccc4ccccc4n3)cc2)=C1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC1(C)OC(=O)C(c2ccc(OCc3ccc4ccccc4n3)cc2)=C1OS(=O)(=O)C(F)(F)F,,ClCCl,O,,,val
US20030162764A1,C1CCNCC1.O=C(CBr)Nc1cc(Cl)nc(-c2ccccc2)n1>>O=C(CN1CCCCC1)Nc1cc(Cl)nc(-c2ccccc2)n1,,CC#N,,,,val
US06313122B1,COc1ccc(C(=O)Nc2ccccc2OC(=O)c2ccc(OC)cc2)cc1>>COc1ccc(C(=O)Nc2ccccc2O)cc1,,CO,,[Na+].[OH-],,val
US20110312945A1,CCOC(=O)Cn1c(C)c(Cc2ccccc2S(=O)(=O)N(C)C)c2c1CC(C)(C)CC2=O>>Cc1c(Cc2ccccc2S(=O)(=O)N(C)C)c2c(n1CC(=O)O)CC(C)(C)CC2=O,,C1CCOC1,O,[Na+].[OH-],,val
US20060160800A1,O=Cc1ccc(-c2ccccc2)c(F)c1>>OCc1ccc(-c2ccccc2)c(F)c1,,CCO,,[Na+].[OH-],,val
US20120129840A1,C1CCNCC1.COC(=O)Cc1c(C)nc(Cl)nc1-c1ccccc1.O=C([O-])O>>COC(=O)Cc1c(C)nc(N2CCCCC2)nc1-c1ccc(C)cc1,,O=C([O-])O,[Na+],C1CCOC1,,val
US20070167452A1,COCOc1ccc(C(=O)NC[C@@H]2CC[C@H](O)CC2)cc1.O=C(O)c1ccccc1>>COCOc1ccc(C(=O)NC[C@@H]2CC[C@@H](OC(=O)c3ccccc3)CC2)cc1,,c1ccccc1,,CCCCP(=CC#N)(CCCC)CCCC,,val
US20090054440A1,COC(=O)COc1c(-c2ccccc2)nc2ccccc2c1C(=O)NN(C(=O)OC)c1ccccc1>>COC(=O)N(NC(=O)c1c(OCC(=O)O)c(-c2ccccc2)nc2ccccc12)c1ccccc1,,CO,,O,[Na+].[OH-],val
US20070185165A1,COCCc1nonc1-c1noc(=O)n1-c1ccc(F)c(Cl)c1>>O=c1onc(-c2nonc2CCO)n1-c1ccc(F)c(Cl)c1,,ClCCl,,BrB(Br)Br,,val
US20080096877A1,CC(=O)N1CCNCC1.CN(c1cccc2cc(-c3ncc(CCl)s3)[nH]c12)S(=O)(=O)c1cccs1>>CC(=O)N1CCN(Cc2cnc(-c3cc4cccc(N(C)S(=O)(=O)c5cccs5)c4[nH]3)s2)CC1,,O,,CCN(CC)CC,CN(C)C=O,val
US20070106077A1,COC(=O)N1CC=C[C@H]2OC(N)=N[C@H]21>>COC(=O)N1CC=C[C@H]2NC(=O)N[C@H]21,,CN(C)C=O,,,,val
US06018056,Br[Mg]c1ccc(OCCN2CCCCC2)cc1.COC(=O)c1c(-c2ccc(OC)cc2)sc2cc(OC)ccc12>>COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1,,C1CCOC1,,,,val
US20090023729A1,BrBr.CCC(C)c1ccc(O)cc1>>CCC(C)c1ccc(O)c(Br)c1,,ClC(Cl)Cl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20030114436A1,CC(C)(C)OC(=O)N1CCC[C@@H](Nc2ccccc2N)C1.O=C(Cl)Cl>>CC(C)(C)OC(=O)N1CCCC[C@@H]1n1c(=O)[nH]c2ccccc21,,ClCCl,,CCN(CC)CC,,val
US20120029190A1,Cc1cccc(-c2nc3c(o2)CNCC3)c1.N#Cc1cccnc1Cl>>Cc1cccc(-c2nc3c(o2)CN(c2ncccc2C#N)CC3)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20120184548A1,COc1cc(C=O)c([N+](=O)[O-])cc1OC>>COc1cc(N)c(C=O)cc1OC,[Fe],CC(=O)O,CCO,Cl,O,val
US06001849,CC(C)(C)OC(=O)N1CCC[C@H]1c1cc2ncc(Br)cc2o1.Cc1ccccc1>>CC(C)(C)OC(=O)N1CCC[C@H]1c1cc2ncc(-c3ccccc3)cc2o1,[Pd],,,O=C([O-])[O-].[Na+].[Na+],,val
US20070167631A1,CCOC(=O)c1ccc(C(F)(F)F)c(O)n1.O=P(Cl)(Cl)Oc1ccccc1>>CCOC(=O)c1ccc(C(F)(F)F)c(Cl)n1,,CCOC(C)=O,,,,val
US20160075692A1,NC1CC1.O=C(O)CN1CCN(c2cccc3c2cnn3-c2ccccc2F)C1=O>>O=C(CN1CCN(c2cccc3c2cnn3-c2ccccc2F)C1=O)NC1CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090170828A1,CC(C)(C)OC(=O)N1CC(O)C1.FC(F)(F)c1ccccc1CBr>>CC(C)(C)OC(=O)N1CC(OCc2ccccc2C(F)(F)F)C1,,CN(C)C=O,,[H-].[Na+],,val
US20040236109A1,CC(=O)N1c2ccc(N)cc2C(C)(c2ccccc2)CC1(C)C.Cc1ccccc1S(=O)(=O)Cl>>CC(=O)N1c2ccc(NS(=O)(=O)c3ccccc3C)cc2C(C)(c2ccccc2)CC1(C)C,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080280875A1,Cn1ccc(NC(=O)c2cc(Oc3ccc(C#N)nc3)c3c(c2)OC(C)(C)C3)n1.[NH4+].[OH-]>>Cn1ccc(NC(=O)c2cc(Oc3ccc(C(=N)NO)nc3)c3c(c2)OC(C)(C)C3)n1,,CCO,O,,,val
US20130142737A1,Cc1cc(CCl)c(O)c(-n2nc3ccccc3n2)c1.O>>Cc1cc(CO)c(O)c(-n2nc3ccccc3n2)c1,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US06174889B1,O=S(Cl)Cl.Oc1ncnc2cnc(OCc3ccccc3)cc12>>Clc1ncnc2cnc(OCc3ccccc3)cc12,CN(C)C=O,,,,,val
US04093622,Clc1cccs1.O=C(O)c1ccc([N+](=O)[O-])o1>>O=C(Cl)c1ccc([N+](=O)[O-])o1,,CN(C)C=O,,CCOCC,,val
US20030105074A1,COc1ccc(CCl)cc1.O=C1NC(=O)c2ccccc21>>COc1ccc(CN2C(=O)c3ccccc3C2=O)cc1,,CN(C)C=O,,[K],,val
US20080297033A1,Nc1ccc(Cc2ccccc2)cc1.O=C1CCC(=O)N1Br>>Nc1ccc(Cc2ccccc2)cc1Br,,CN(C)C=O,,,,val
US20070027178A1,COCCOC.Cc1c(F)cc(Cl)c2[nH]c3c(c12)CN(C(=O)OC(C)(C)C)CC3>>Cc1c(F)cc(Cl)c2c1c1c(n2C)CCN(C(=O)OC(C)(C)C)C1,,O,,[K+].[OH-],,val
US20090036492A1,COc1cc(OC)c2c(c1C(=O)OCc1ccccc1)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C>>COc1cc(OC)c2c(c1C(=O)O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,[Pd],CCOC(C)=O,,[H][H],,val
US20120142677A1,CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2)no1.O=C(Cl)N1CCS(=O)(=O)CC1>>CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2C(=O)N2CCS(=O)(=O)CC2)no1,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,Cl,val
US20150175599A1,Cc1cc2cc([N+](=O)[O-])ccc2n1Cc1ccc(Cl)cc1>>Cc1cc2cc(N)ccc2n1Cc1ccc(Cl)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130287699A1,CC1(C)OB(c2ccc(CBr)cc2)OC1(C)C.N#Cc1nc2ccc(O)cc2s1>>CC1(C)OB(c2ccc(COc3ccc4nc(C#N)sc4c3)cc2)OC1(C)C,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150225449A1,COC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@H](C)N.O=[N+]([O-])c1ccccc1F>>COC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@H](C)Nc1ccccc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20100267666A1,Brc1cnc2[nH]ccc2n1.COc1cc(B(O)O)cc(OC)c1OC>>COc1cc(-c2cnc3[nH]ccc3n2)cc(OC)c1OC,,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20050209226A1,CCCC=C1CCNCC1.O=C1COc2ccccc2N1CCCCl>>CCCC=C1CCN(CCCN2C(=O)COc3ccccc32)CC1,,CO,ClCCl,[I-].[K+],O=C([O-])O.[Na+],val
US20150045378A1,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ccc(OCc2ccccc2)cc1C=O>>CCOC(=O)C=Cc1cc(OCc2ccccc2)ccc1C,,Cc1ccccc1,,,,val
US04524212,C[C@H](CC(=O)[C@H](Cc1ccccc1)OC(=O)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1>>C[C@H](CC(=O)[C@H](Cc1ccccc1)OC(=O)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)O,[Pd],CCOC(C)=O,,,,val
US20120059001A1,CCC(=O)OC(=O)CC.O=C(Cc1cccc(F)c1)c1cc(F)ccc1O>>CCc1oc2ccc(F)cc2c(=O)c1-c1cccc(F)c1,,CCN(CC)CC,,Cl,,val
US20060046999A1,C#CC(=O)OC.COc1ccc(NC(=N)CC(=O)c2ccc(F)cc2F)cc1>>COc1ccc(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)cc1,,CO,,CCOCC,,val
US20150119374A1,CC(=O)C=O.C[C@H](N)C(=O)NO>>Cc1c[n+]([O-])c(O)c(C)n1,,O,,CO,[Na+].[OH-],val
US20150218170A1,Cn1ncc2c1CCCN2c1cnc2c(n1)c(C(=O)NC(C)(C)C)cn2COCC[Si](C)(C)C>>Cn1ncc2c1CCCN2c1cnc2[nH]cc(C(=O)NC(C)(C)C)c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100120798A1,CC(C)(C)OC(=O)N1CCC(C#N)(C(=O)O)CC1.NCc1cc2ccccc2[nH]1>>CC(C)(C)OC(=O)N1CCC(C#N)(C(=O)NCc2cc3ccccc3[nH]2)CC1,,CC(=O)N(C)C,CCOC(C)=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100063078A1,Cl.Clc1ccc2c(c1)CCC21CCNC1.O=c1[nH]c(=O)n(CCCCl)cc1-c1cccs1>>Cl.O=c1[nH]c(=O)n(CCCN2CCC3(CCc4cc(Cl)ccc43)C2)cc1-c1cccs1,,CN1CCCC1=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20120302549A1,N#CN[C@]1(C(F)(F)CO)CCc2ccc([N+](=O)[O-])cc21>>NC1=N[C@@]2(CCc3ccc([N+](=O)[O-])cc32)C(F)(F)CO1,,CO,,[NH4+].[OH-],,val
US20040058903A1,CC(=O)Cl.CN(CCc1ccccn1)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1N>>CC(=O)Nc1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)ccc1N(C)CCc1ccccn1,,C1CCOC1,O,CCN(CC)CC,CCOC(C)=O,val
US20120065183A1,COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)OC(C)(C)C)C4)c3C2)cc1C(F)(F)F.Cl.ClCCl>>COc1ncc(N2CCc3ncnc(O[C@H]4CCNC4)c3C2)cc1C(F)(F)F.Cl.Cl,,ClCCl,,CCOCC,,val
US20150353553A1,COc1cccc(B(O)O)c1.C[C@@H](Nc1nc(C#N)nc2nc(Br)n(Cc3ccc(C(F)(F)F)cc3)c12)C1CCC1>>COc1cccc(-c2nc3nc(C#N)nc(N[C@H](C)C4CCC4)c3n2Cc2ccc(C(F)(F)F)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20130231327A1,COC(=O)c1ccc2c(c1)[C@H](N)CC2.Cc1ccccc1C(=O)Cl>>COC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccccc1C)CC2,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20110105461A1,CS(=O)(=O)c1ccc2c(c1)OC(CO)CO2.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCC2COc3ccc(S(C)(=O)=O)cc3O2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20060217372A1,Cc1cc(C2OCCO2)ccc1Oc1cnc(C#N)cn1.OO>>Cc1cc(C2OCCO2)ccc1Oc1cnc(C(N)=O)cn1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090291971A1,N#Cc1ccc(B(O)O)cc1.c1ccc2c(On3nnc4cccnc43)ncnc2c1>>N#Cc1ccc(Oc2ncnc3ccccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04917817,CCCCBr.O=C(O)C(F)(F)F>>CCCCC(=O)C(F)(F)F,,CCOCC,,Cl,[Mg],val
US20130165464A1,CNC.O=Cc1ccc(Cl)c(Br)c1>>CN(C)Cc1ccc(Cl)c(Br)c1,,ClCCl,,,,val
US20110039847A1,CC[Mg]Br.N#Cc1ccccc1N.O>>CCC(=O)c1ccccc1N,,O,,C1CCOC1,,val
US20040006081A1,CN(C(=O)Cc1ccc(F)cc1)C1CCN(CCC(O)c2ccccc2)CC1.CS(=O)(=O)Cl>>CN(C(=O)Cc1ccc(F)cc1)C1CCN(CCC(Cl)c2ccccc2)CC1,,ClCCl,,,,val
US05312815,CC(C)[Mg]Br.O=C(Cl)c1ccc(F)cc1F>>CC(C)C(=O)c1ccc(F)cc1F,Cl[Cu],O,,CCOCC,Cl,val
US20070232632A1,CS(=O)c1ccc([N+](=O)[O-])cc1.[N-]=[N+]=[N-]>>CS(=N)(=O)c1ccc([N+](=O)[O-])cc1,,ClC(Cl)Cl,,O=S(=O)(O)O,,val
US20150307480A1,COC(=O)c1cc(Cl)cc(O)c1C.OC1CCOCC1>>COC(=O)c1cc(Cl)cc(OC2CCOCC2)c1C,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080009509A1,O=[N+]([O-])c1cc2c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1>>Nc1cc2c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1,[Fe],CC(=O)O,CCOC(C)=O,,,val
US20140315894A1,CCOC(=O)CC(=O)c1ccc(OC)c(OC)c1.NNc1ccccc1>>COc1ccc(C2=NN(c3ccccc3)C(=O)C2)cc1OC,,CCO,,,,val
US04303656,CN(C)CC1CC(O)(c2ccc(Cl)cc2)c2ccccc2O1>>CN(C)CC1C=C(c2ccc(Cl)cc2)c2ccccc2O1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20090247526A1,CC(C)(C)OC(=O)CBr.Cc1csc(Nc2cc(Sc3cccc(O)c3)ccn2)n1>>Cc1csc(Nc2cc(Sc3cccc(OCC(=O)OC(C)(C)C)c3)ccn2)n1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20110269738A1,CC(C)Cc1ccc(C(=O)O)cc1C#N.NNC(N)=S>>CC(C)Cc1ccc(-c2nnc(N)s2)cc1C#N,,O=P(Cl)(Cl)Cl,,,,val
US20090062534A1,CC(=O)NC[C@H]1CN(c2ccc(N3CCOCC3)c(F)c2)C(=O)O1.O=S(=O)(O)O>>CC(=O)NC[C@H]1CN(c2ccc(N3CCOCC3)c(F)c2)C(=O)O1.O=S(=O)([O-])[O-],,C1CCOC1,,,,val
US20110251190A1,CC(C)(C#N)COS(=O)(=O)C(F)(F)F.NC1=N[C@@]2(CO1)c1cc(Br)ccc1Oc1c(F)cc(O)cc12>>CC(C)(C#N)COc1cc(F)c2c(c1)[C@]1(COC(N)=N1)c1cc(Br)ccc1O2,,CN(C)C=O,,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US20070021445A1,CC(=O)c1c(C)cc(C)cc1C.CNc1nc(N)nc(N)c1C=O>>CNc1nc(N)nc2nc(-c3c(C)cc(C)cc3C)ccc12,,CCO,,[K+].[OH-],,val
US04371736,Clc1cnc(Cl)nc1.O=[N+]([O-])c1ccc(Cl)nc1.Oc1ccccc1S>>O=[N+]([O-])c1ccc(Sc2ccccc2Oc2ncc(Cl)cn2)nc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20070155726A1,COC(=O)c1ccc(CN(C)CC2CCCCN2C(=O)OC(C)(C)C)cc1>>COC(=O)c1ccc(CN(C)CC2CCCCN2)cc1,,C1COCCO1,ClCCl,Cl,,val
US05612363,N#Cc1cccc(CBr)c1.O=c1[nH]c(-c2ccccc2)c(-c2ccccc2)[nH]1>>N#Cc1cccc(Cn2c(-c3ccccc3)c(-c3ccccc3)[nH]c2=O)c1,,CN(C)C=O,,[H-].[Na+],,val
US06017919,N#CCc1ccc(OCc2ccccc2)cc1>>NCCc1ccc(OCc2ccccc2)cc1,,C1CCOC1,,[H-].[Na+],,val
US20160206616A1,COC(=O)C(C)=C[C@@H]1CC(F)(F)CN1C(=O)OC(C)(C)C>>COC(=O)C(C)C[C@@H]1CC(F)(F)CN1C(=O)OC(C)(C)C,[Pd],CO,,,,val
US05126337,CCOC(=O)CC(=O)OCC.COCCl.Fc1ccc(N=C=S)c(Cl)c1F>>CCOC(=O)c1c(SCOC)nc2c(Cl)c(F)c(F)cc2c1O,,C1CCOC1,,[H-].[Na+],,val
US04812164,CCO.CCOC(=O)c1cc(-n2c(Cl)nc(C(F)(F)F)cc2=O)c(F)cc1Cl>>CCOC(=O)c1cc(-n2c(OCC)nc(C(F)(F)F)cc2=O)c(F)cc1Cl,,CCO,,C,C[O-].[Na+],val
US05155113,CC(=O)Cl.O=c1cc(O)c(Cl)c[nH]1>>CC(=O)Oc1cc(=O)[nH]cc1Cl,,c1ccncc1,,,,val
US20030018064A1,CCOC(=O)CCC(=O)CSc1cccc(OC(C)=O)c1>>CCOC(=O)CCc1csc2cc(O)ccc12,,O=S(=O)(O)O,,,,val
US20040077669A1,Fc1cccc(Nc2cc(Cl)ncn2)c1F.N#CCBr>>N#CCN(c1cc(Cl)ncn1)c1cccc(F)c1F,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20060252790A1,CCOC(=O)c1cnc2c(cnn2CC)c1NC1CCCC1>>CCn1ncc2c(NC3CCCC3)c(C(=O)O)cnc21,,CCO,O,[Na+].[OH-],,val
US20100204159A1,C=CCCCCCCCC1(S(N)(=O)=O)CC1.C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)O>>C=CCCCCCCCC1(S(=O)(=O)NC(=O)[C@@]2(NC(=O)OC(C)(C)C)C[C@H]2C=C)CC1,,C1CCOC1,,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US06380218B1,CCOC(=O)c1cccnc1Cl.OCc1cccnc1>>CCOC(=O)c1cccnc1OCc1cccnc1,,O,,CN(C)C=O,,val
US20030027847A1,COC(=O)c1ccc(O)cc1.Fc1ccc(CCl)cc1>>COC(=O)c1ccc(OCc2ccc(F)cc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120277244A1,CC(C)(C)OC(=O)/N=C(/c1cc(Br)ccc1F)C(F)F.C[N+](=O)[O-]>>CC(C)(C)OC(=O)NC(C[N+](=O)[O-])(c1cc(Br)ccc1F)C(F)F,,COC(C)(C)C,,C1CCC2=NCCCN2CC1,,val
US05952341,CC(C)(C)OC(=O)N1CCCC(Cc2ccc3c(n2)NCCC3)C1>>c1cc2c(nc1CC1CCCNC1)NCCC2,,CCOC(C)=O,,Cl,,val
US20100297054A1,COC(=O)c1nnn(Cc2ccc(Cl)c(Cl)c2)c1C>>Cc1c(C(=O)O)nnn1Cc1ccc(Cl)c(Cl)c1,,CO,,O,[Na+].[OH-],val
US20070197512A1,COC(=O)CCN1C(=O)C(C(C)C)Oc2cc(Cl)ccc21>>CC(C)C1Oc2cc(Cl)ccc2N(CCC(=O)O)C1=O,,CO,,[Na+].[OH-],,val
US20070049593A1,COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCOc1cc(OC2CCCN(C(=O)OC(C)(C)C)C2)ccc1-3>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCOc1cc(OC2CCCNC2)ccc1-3,,O=C(O)C(F)(F)F,,Cc1ccccc1,,val
US20140228371A1,COC(=O)c1cc(N)ccn1.O=C(Cl)c1nc2ccccc2nc1Cl>>COC(=O)c1cc(NC(=O)c2nc3ccccc3nc2Cl)ccn1,,ClCCl,,O,c1ccncc1,val
US20150105393A1,CC(C)C(=O)Nc1cc(C(C)N)ccn1.O=C=Nc1ccc(OC(F)(F)F)cc1>>CC(C)C(=O)Nc1cc(C(C)NC(=O)Nc2ccc(OC(F)(F)F)cc2)ccn1,,CC(=O)N(C)C,CCOC(C)=O,CCN(C(C)C)C(C)C,Cl,val
US05240938,CC(C)(C)[Si](C)(C)Oc1c(Cl)cc(CO)cc1Cl>>OCc1cc(Cl)c(O)c(Cl)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20010039344A1,CCOC(=O)c1csc(NC(=O)C(CC2CCCC2)c2cccc(Cl)c2)n1>>COC(=O)c1csc(NC(=O)C(CC2CCCC2)c2cccc(Cl)c2)n1,,CO,,O=S(=O)(O)O,,val
US04255429,COc1cc2nc(Cl)nc(N)c2cc1OC.O=C1CC2(CCCC2)CC(=O)N1C1CCNCC1>>COc1cc2nc(N3CCC(N4C(=O)CC5(CCCC5)CC4=O)CC3)nc(N)c2cc1OC.Cl,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20160175289A1,CC(=O)OCCOc1cc(F)c(C=O)c(F)c1.C[C@H](Cc1c[nH]c2ccccc12)NCC(C)(C)F>>CC(=O)OCCOc1cc(F)c([C@@H]2c3[nH]c4ccccc4c3C[C@@H](C)N2CC(C)(C)F)c(F)c1,,Cc1ccccc1,,CC(=O)O,,val
US20130109708A1,COc1cc(C)ccc1C(=O)O.CS(N)(=O)=O>>COc1cc(C)ccc1C(=O)NS(C)(=O)=O,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US04232032,CI.Oc1ccc2c(c1)C(C(Cl)(Cl)Cl)OC(C(Cl)(Cl)Cl)O2>>COc1ccc2c(c1)C(C(Cl)(Cl)Cl)OC(C(Cl)(Cl)Cl)O2,,CCO,,[Na+].[OH-],,val
US20070142443A1,CC(=O)[O-].COC(=O)CC(=O)CC(C)C.[NH4+]>>CC(=O)O.COC(=O)CC(N)CC(C)C,,CO,,,,val
US20090075971A1,C=C[C@H]1OC(C)(C)O[C@H]2[C@@H](OCC)C(=O)O[C@@H]12>>C=C[C@@H](O)[C@@H]1OC(=O)[C@H](OCC)[C@@H]1O,,O,,O=C(O)C(F)(F)F,,val
US20070299260A1,C1=COCCC1.CCOC(=O)CN1C2CC(O)CC1CC(C(=O)OCC)C2.CS(=O)(=O)O>>CCOC(=O)CN1C2CC(OC3CCCCO3)CC1CC(C(=O)OCC)C2.CS(=O)(=O)O,,COCCOC,,COC(C)(C)C,,val
US20090137609A1,CCC(CC)(c1ccc(CCC(O[Si](C)(C)C(C)(C)C)C(C)(C)C)c(C)c1)c1ccc(B2OC(C)(C)C(C)(C)O2)c(C)c1.COC(=O)C(O)c1ccc(Br)cc1>>CCC(CC)(c1ccc(CCC(O[Si](C)(C)C(C)(C)C)C(C)(C)C)c(C)c1)c1ccc(-c2ccc(C(O)C(=O)OC)cc2)c(C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US05698584,CSc1ccc(C(=O)C(C)(C)O)cc1.O=C(Cl)CCc1ccccc1>>CSc1ccc(C(=O)C(C)(C)OC(=O)CCc2ccccc2)cc1,,ClCCl,,CCOC(C)=O,c1ccncc1,val
US20070293515A1,Clc1ncnc2c1cnn2C1CCCCO1.N[C@H]1CCN(c2nc(-c3ccccc3)no2)C1>>c1ccc(-c2noc(N3CC[C@H](Nc4ncnc5[nH]ncc45)C3)n2)cc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US07495007B2,CCOC(=O)C(C)(C)Oc1ccc(Br)cc1C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12>>CC(C)(CO)Oc1ccc(Br)cc1C1NC(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06706725B1,C#C/C=C(\CC)c1ccc(COc2ccc(CO[Si](C)(C)C(C)(C)C)c(CO[Si](C)(C)C(C)(C)C)c2)s1.O=C(C(F)(F)F)C(F)(F)F>>CC/C(=C\C#CC(O)(C(F)(F)F)C(F)(F)F)c1ccc(COc2ccc(CO[Si](C)(C)C(C)(C)C)c(CO[Si](C)(C)C(C)(C)C)c2)s1,,C1CCOC1,,[Li]CCCC,,val
US20050065162A1,COc1ccc(C(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)OCc2ccccc2)cc1OC.O=C(O)C(F)(F)F>>COc1ccc(C2=N[C@H](C(=O)OCc3ccccc3)CC2)cc1OC.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20090221555A1,CC1CNC(=O)c2c(cccc2[N+](=O)[O-])N1.CC1CNc2cccc([N+](=O)[O-])c2C(=O)N1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(=O)N1CC(C)NC(=O)c2c1cccc2[N+](=O)[O-],,ClCCl,,CCN(C(C)C)C(C)C,[Cl-].[NH4+],val
US05262540,CO.O=C(O)CCCCCCCCc1nc(-c2ccccc2)c(-c2ccccc2)o1>>COC(=O)CCCCCCCCc1nc(-c2ccccc2)c(-c2ccccc2)o1,O=S(=O)(O)O,CCOCC,,,,val
US20100160388A1,C=C(/C=C/OC)O[Si](C)(C)C.C[Si](C)(C)CCS(=O)(=O)N=Cc1cccnc1>>C[Si](C)(C)CCS(=O)(=O)N1C=CC(=O)CC1c1cccnc1,,Cc1ccccc1,,,,val
US20030018197A1,CCn1nc(C)c(CCBr)c1Sc1cc(Cl)cc(Cl)c1.Nc1cccnc1>>CCn1nc(C)c(CNc2cccnc2)c1Sc1cc(Cl)cc(Cl)c1,,CN(C)C=O,,O,[H-].[Na+],val
US20070173488A1,CC(C)(C)OC(=O)Nc1cc(N)n[nH]1.CCOC(=O)N=C=S>>CCOC(=O)Nc1nc2[nH]nc(NC(=O)OC(C)(C)C)c2s1,,C1CCOC1,,O=C1CCC(=O)N1Br,,val
US04859229,CN(C)C(=O)Cl.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(OCCO)c(Cl)cc2F)c1=O>>CN(C)C(=O)OCCOc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl,,Cc1ccccc1,,CCN(CC)CC,,val
US04638071,C=C(C)C1CC=C(C)CC1.COC(=O)[C@H](CS)NC(=O)OCc1ccccc1>>COC(=O)[C@H](CSC(C)(C)C1CC=C(C)CC1)NC(=O)OCc1ccccc1,,CCOCC,,,,val
US20020004511A1,Cc1cc2cc(N)ccc2[nH]1.Cc1cnc(-c2cc3nccc(Cl)c3s2)o1>>Cc1cc2cc(Nc3ccnc4cc(-c5ncc(C)o5)sc34)ccc2[nH]1,,CCO,,,,val
US20060025474A1,CCOC(=O)CCCCOc1ccc(C(CC)(CC)c2ccc(CCC(O)C(C)(C)C)c(C)c2)cc1C>>CCC(CC)(c1ccc(CCC(O)C(C)(C)C)c(C)c1)c1ccc(OCCCCC(=O)O)c(C)c1,,CO,,Cl,[K+].[OH-],val
US20140038919A1,CS(=O)(=O)N(CCCC(=O)NN)c1cc2oc(-c3ccc(F)cc3)c(-c3ncc[nH]3)c2cc1C1CC1.O=C(Cl)Cl>>CS(=O)(=O)N(CCCc1n[nH]c(=O)o1)c1cc2oc(-c3ccc(F)cc3)c(-c3ncc[nH]3)c2cc1C1CC1,,C1CCOC1,ClC(Cl)Cl,Cc1ccccc1,,val
US05029979,CC(=O)OCCOc1ccc(C=O)cc1.COP(=O)(Cc1ccc(S(C)(=O)=O)cc1)OC>>CC(=O)OCCOc1ccc(C=Cc2ccc(S(C)(=O)=O)cc2)cc1,,COCCOC,,[H-].[Na+],,val
US20120214785A1,CCCOc1ccc(C#Cc2ccc(C(C)CNC(=O)OC(C)(C)C)cc2)cc1>>CCCOc1ccc(C#Cc2ccc(C(C)CN)cc2)cc1,,CO,,Cl,,val
US04233056,C=O.O=C(O)CNCc1ccccc1.OCP(O)O>>O=C(CNCc1ccccc1)CP(=O)(O)CO,,Cl,,,,val
US20080269194A1,COc1ccc(CN2C(=O)CN=C(c3ccc(OC)cc3)c3cc(Cl)ccc32)cc1.Clc1ccccc1CBr>>COc1ccc(CN2C(=O)C(Cc3ccccc3Cl)N=C(c3ccc(OC)cc3)c3cc(Cl)ccc32)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20110201615A1,CCOC(=O)C[N+](=O)[O-].CN(C)Cc1c[nH]c2cccc(C#N)c12>>CCOC(=O)C(Cc1c[nH]c2cccc(C#N)c12)[N+](=O)[O-],,Cc1ccccc1C,,,,val
US20140212486A1,CC(C)=CCC[C@@H](C)O.CS(=O)(=O)Cl>>CC(C)=CCC[C@@H](C)OS(C)(=O)=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04800201,CC1=CSCC(=O)N1.O=C(Cl)OCC(Cl)(Cl)Cl.O=Cc1cccnc1>>CC1=C(C2C=CN(C(=O)OCC(Cl)(Cl)Cl)C=C2C=O)SCC(=O)N1,,CC#N,,,,val
US20020086886A1,NS(=O)(=O)c1ccc(-c2oc(CCNC(=O)OCc3ccccc3)nc2-c2ccccc2)cc1>>NCCc1nc(-c2ccccc2)c(-c2ccc(S(N)(=O)=O)cc2)o1,[Pd],CO,,CC(=O)O,,val
US05177196,Cc1cn([C@H]2O[C@H](COC(=O)c3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@@H]2OC(=O)c2ccccc2)c(=O)[nH]c1=O>>Cc1cn([C@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)[nH]c1=O,,CO,,C[O-].[Na+],,val
US20070037806A1,CC(C)(C)[Si](C)(C)Cl.CCOC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C>>CCOC(=O)[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,O,CCN(CC)CC,,val
US20140179670A1,Cc1c(-c2c(S(=O)(=O)Cl)cnn2-c2ccc(C#N)cc2)c(=O)n(C)c(=O)n1-c1cccc(C(F)(F)F)c1.N[C@H](CO)c1ccccc1>>Cc1c(-c2c(S(=O)(=O)N[C@H](CO)c3ccccc3)cnn2-c2ccc(C#N)cc2)c(=O)n(C)c(=O)n1-c1cccc(C(F)(F)F)c1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20140364414A1,NC(=O)CCC(=O)NBr.c1ccc2nc(OCc3cn4ccnc(N5CCOCC5)c4n3)ccc2c1>>Brc1cnc(N2CCOCC2)c2nc(COc3ccc4ccccc4n3)cn12,,ClCCl,,,,val
US20140100231A1,COc1ccc(Cn2nc(Cn3cnc(C(F)(F)F)c(Oc4cc(Cl)cc(C#N)c4)c3=O)cc(C=O)c2=O)cc1.C[Si](C)(C)C(F)(F)F>>COc1ccc(Cn2nc(Cn3cnc(C(F)(F)F)c(Oc4cc(Cl)cc(C#N)c4)c3=O)cc(C(O)C(F)(F)F)c2=O)cc1,,C1CCOC1,O,[Cs+].[F-],,val
US20050267152A1,CCc1cccc(CC)n1>>CCC1CCCC(CC)N1,O=[Pt],CC(=O)O,,,,val
US20080085886A1,CCOC(=O)CO.CCOC(=O)c1c(Cl)ccnc1Cl>>CCOC(=O)c1oc2ccnc(Cl)c2c1O,,CN(C)C=O,,[H-].[Na+],,val
US20140315888A1,Nc1ccc(C(F)(F)F)cn1.O=[N+]([O-])O>>Nc1ncc(C(F)(F)F)cc1[N+](=O)[O-],,O=S(=O)(O)O,,[Na+].[OH-],,val
US20080009513A1,CC(=O)CNc1ccccc1Cl.O=C1CCN(N2CCCCC2)C(=O)C1>>Cc1cn(-c2ccccc2Cl)c2c1C(=O)N(N1CCCCC1)CC2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140024649A1,CC(C)C=O.Cc1oc(-c2ccc(C(=O)NCc3cccnc3)cc2)nc1CS(=O)(=O)C1CCNCC1>>Cc1oc(-c2ccc(C(=O)NCc3cccnc3)cc2)nc1CS(=O)(=O)C1CCN(CC(C)C)CC1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20080009530A1,C=CCCBr.CCOC(=O)CCc1ccc(O)cc1Oc1ncc(C(F)(F)F)cc1Cl>>C=CCCOc1ccc(CCC(=O)OCC)c(Oc2ncc(C(F)(F)F)cc2Cl)c1,,CN(C)C=O,,O,[H-].[Na+],val
US05493030,COC(=O)c1cccc(C)c1/C=C/Cc1c(OC)c(C)c2c(c1OC(C)=O)C(=O)OC2>>COc1c(C)c2c(c(OC(C)=O)c1C/C=C/c1c(C)cccc1C(=O)O)C(=O)OC2,,CO,O,Cl,[Li+].[OH-],val
US20040242868A1,Cc1ccc(N)cc1-c1ccc(C(=O)NCC2CC2)cc1.O=C(O)c1nc(N2CCCCC2)ncc1Cl>>Cc1ccc(NC(=O)c2nc(N3CCCCC3)ncc2Cl)cc1-c1ccc(C(=O)NCC2CC2)cc1,,C1CCOC1,,,,val
US20070219230A1,Cc1c(C)n(Cc2cccc(F)c2)c2c(N3CCc4ccccc4C3)nc(C=O)cc12.Cl>>Cc1c(C)n(Cc2cccc(F)c2)c2c(N3CCc4ccccc4C3)nc(C=O)cc12.Cl,,CCOC(C)=O,,,,val
US20100197665A1,CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(S(=O)(=O)c5ccccc5)cc34)c(N)c2)CC1.O=C(Cl)c1ccc[nH]1>>CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(S(=O)(=O)c5ccccc5)cc34)c(NC(=O)c3ccc[nH]3)c2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040176377A1,CCOC(=O)C(O)(CC(=O)c1ccc(OCc2ccccc2)cc1)C(=O)OCC.NN>>CCOC(=O)c1cc(-c2ccc(OCc3ccccc3)cc2)n[nH]c1=O,,CCO,,Cl,Cl,val
US06339083B1,COC(=O)CC1Nc2ccc(-c3nc(-c4nc5ccccc5[nH]4)no3)cc2CN(C2CC2)C1=O>>O=C(O)CC1Nc2ccc(-c3nc(-c4nc5ccccc5[nH]4)no3)cc2CN(C2CC2)C1=O,,COCCOC,,O,[Li+].[OH-],val
US20070167488A1,CCCI.O=Cc1c[nH]c2ccccc12>>CCCn1cc(C=O)c2ccccc21,,CS(C)=O,,[K+].[OH-],,val
US20090156593A1,O=C=NC1(c2cccs2)CCC2(CC1)OCCO2>>CNC1(c2cccs2)CCC2(CC1)OCCO2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20080139610A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1cc(N2CCc3cc(C(F)(F)F)ccc3C2)cc(C)c1NC(=O)CC(C)(C)C>>Cc1cc(N2CCc3cc(C(F)(F)F)ccc3C2)cc(C)c1NC(=S)CC(C)(C)C,,CC(Cl)Cl,,,,val
US20090192190A1,Cc1ccc(C(C)(C)C)c(O)c1C(=O)O.ClI>>Cc1c(I)cc(C(C)(C)C)c(O)c1C(=O)O,,CN(C)C=O,CS(C)=O,,,val
US20070191309A1,COc1cc([N+](=O)[O-])c(C(=O)N2CCCC2CO)cc1OCc1ccccc1>>COc1cc(N)c(C(=O)N2CCCC2CO)cc1OCc1ccccc1,,CO,,Cl[Sn]Cl,,val
US20150210722A1,CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)n(-c2cccc(CP(C)(C)=O)c2)n1.COCCOCCOCCOc1cc(N)cc(OC)c1>>COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(CP(C)(C)=O)c4)c4ccccc34)n2)cc(OC)c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20130338081A1,O=C1C[C@@H](C(=O)N[C@@H]2CCCc3ccccc32)N(C(=O)OCc2ccccc2)C1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C(N[C@@H]1CCCc2ccccc21)[C@@H]1C=C(OS(=O)(=O)C(F)(F)F)CN1C(=O)OCc1ccccc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20120295924A1,CI.CN(C)C=O.Cc1cc2c(=O)[nH]c(=O)[nH]c2s1>>Cc1cc2c(=O)n(C)c(=O)n(C)c2s1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100087431A1,BrCCCBr.N#CCc1ccc(F)cc1Br>>N#CC1(c2ccc(F)cc2Br)CCC1,,Cc1ccccc1,O,[K+].[OH-],,val
US05064825,CCCC(CC)C(=O)NC#N.CCOC(=O)CN>>CCCCC(=NC#N)NCC(=O)OCC,,CCO,,CCN(CC)CC,Cl,val
US20060063783A1,CC#CCOCC1CCN(S(=O)(=O)CC(C)NO)CC1.O=CO>>CC#CCOCC1CCN(S(=O)(=O)CC(C)N(O)C=O)CC1,,C1CCOC1,,CC(=O)OC(C)=O,,val
US20020103371A1,COc1ccc(CNCC(=O)O)c(OC)c1.Cc1ccc2[nH]c(=O)oc(=O)c2c1>>COc1ccc(CN2CC(=O)Nc3ccc(C)cc3C2=O)c(OC)c1,,Cc1ccc(C)cc1,,,,val
US05137901,COc1cccc2c1OC(CN)CC2.O=C1c2ccccc2S(=O)(=O)N1CCCCBr>>COc1cccc2c1OC(CNCCCCN1C(=O)c3ccccc3S1(=O)=O)CC2,,CN(C)C=O,,CCN(CC)CC,,val
US20060217424A1,CN.Cc1ccc(C#N)c(Oc2cccc(C=O)c2)c1.O=C(O)/C=C/C(=O)O>>CNCc1cccc(Oc2cc(C)ccc2C#N)c1.O=C(O)/C=C/C(=O)O,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US09073882B2,Cc1c(C(C)CN2CCNCC2)ccc2c1COC2=O.Cc1c(CC=O)ccc2c1COC2=O>>Cc1c(CCN2CCN(CC(C)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070259898A1,COC(=O)C(COC(C)(C)C)NC(=O)CCC(C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N>>CC(C)(C)OC[C@H](CO)NC(=O)CC[C@@H](C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N,,CO,,[BH4-].[Na+],,val
US20120028938A1,BrCc1ccc(Br)cc1.COC(=O)Cc1c(C)n[nH]c1C>>COC(=O)Cc1c(C)nn(Cc2ccc(Br)cc2)c1C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04705900,ClC(Cl)(Br)C(Cl)(Cl)Br.OCc1cc(Cl)cc(Cl)c1>>Clc1cc(Cl)cc(CBr)c1,,CCOCC,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20110190334A1,Cc1c(Nc2ccc(Br)cc2F)c([N+](=O)[O-])c2n(c1=O)CCN2C(=O)OC(C)(C)C>>Cc1c(Nc2ccc(Br)cc2F)c(N)c2n(c1=O)CCN2C(=O)OC(C)(C)C,[Zn],C1CCOC1,O,CCOC(C)=O,[Cl-].[NH4+],val
US20040072839A1,COC(=O)Cl.COc1ccccc1N1CCN(CCC(c2ccccc2F)C(O)C2CCCCC2)CC1>>COC(=O)OC(C1CCCCC1)C(CCN1CCN(c2ccccc2OC)CC1)c1ccccc1F,,c1ccncc1,,O,,val
US20150094306A1,O=C1c2ccccc2C(=O)N1Cc1cnc(OCC(F)(F)F)c(Cl)c1>>NCc1cnc(OCC(F)(F)F)c(Cl)c1,,CO,,NN,O,val
US20070213355A1,CC(C)(C)OC(=O)NCCc1ccc(Nc2c(N)cnc3ccc(Br)cc23)cc1.O=CC1CC1>>CC(C)(C)OC(=O)NCCc1ccc(-n2c(C3CC3)nc3cnc4ccc(Br)cc4c32)cc1,,ClCCl,,CC(=O)O,,val
US20110065681A1,CN[C@@H]1CCNC1.Cc1ccc(-c2cc(C(=O)O)cc(C(=O)NCc3ccc(C)nc3)c2)cc1>>Cc1ccc(-c2cc(C(=O)NCc3ccc(C)nc3)cc(C(=O)N(C)[C@@H]3CCNC3)c2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04945158,O=P(C=C[C@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1)(Oc1ccccc1)Oc1ccccc1>>O=P(CC[C@H]1O[C@H](CO)[C@@H](O)[C@@H]1O)(Oc1ccccc1)Oc1ccccc1,[Pd],CC(=O)O,CO,,,val
US20030036658A1,Brc1cccc2cccnc12.O=C1CCc2ccccc21>>OC1(c2cccc3cccnc23)CCc2ccccc21,,C1CCOC1,,Cl,[Li]CCCC,val
US06177427B1,CCCCCC.CS(C)=O.OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1>>CC(C)=CCOC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1,,CS(C)=O,,CCOCC,,val
US20020072524A1,CC(C)(C)OC(=O)N1CC2CC(C1)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc12.CCCCN>>CCCCNc1cc2c(cc1[N+](=O)[O-])C1CC2CN(C(=O)OC(C)(C)C)C1,,C1CCOC1,CCOC(C)=O,,,val
US20120190665A1,CCOC(=O)C(C)(C)Br.COc1ccc(Cl)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12>>CCOC(=O)C(C)(C)n1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC)n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150038574A1,CC1=C(C=O)C(C)(C)CCC1.COc1cccc(N)c1>>COc1cccc(NCC2=C(C)CCCC2(C)C)c1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US04397864,Cc1ccc(F)cc1.O=C1CCC(=O)N1Br>>Fc1ccc(CBr)cc1,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20120082702A1,COC(=O)c1ccc(N)cc1.NC(=O)c1ccc(Cl)nc1Cl>>COC(=O)c1ccc(Nc2nc(Cl)ccc2C(N)=O)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05399542,C=CCBr.CCC(=O)C1=C(O)CC(c2ccc3c(c2)NC(=O)CO3)CC1=O>>C=CCN1C(=O)COc2ccc(C3CC(=O)C(C(=O)CC)=C(O)C3)cc21,,CCCCCC,,[H-].[Na+],,val
US20160068531A1,CCOC(=O)c1c(CCCSC)c2ccc(Cl)cc2n1S(=O)(=O)c1ccccc1>>CSCCCc1c(CO)n(S(=O)(=O)c2ccccc2)c2cc(Cl)ccc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070179191A1,COc1cc(OCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1-c1noc(=O)[nH]1.O=C1CCC(=O)N1Br>>COc1cc(OCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)c(Br)cc1-c1noc(=O)[nH]1,,CC#N,,,,val
US20140060641A1,Clc1cccc(-c2ccccn2)n1.c1cn[nH]c1>>c1ccc(-c2ccccn2)nc1.c1cn[nH]c1,,O,,CC(C)(C)O[K],,val
US20110251186A1,NC1(CCO)c2cc(Br)ccc2Oc2cnc(Cl)cc21.O=C(N=C=S)c1ccc([N+](=O)[O-])cc1>>O=C(NC(=S)NC1(CCO)c2cc(Br)ccc2Oc2cnc(Cl)cc21)c1ccc([N+](=O)[O-])cc1,,C1CCOC1,,,,val
US20130158051A1,CCCOc1nc(Oc2cc(F)ccc2F)nc2oc(-c3cc(C)c(OCC(=O)N4CCC[C@H]4C(=O)OC(C)(C)C)c(C)c3)nc12>>CCCOc1nc(Oc2cc(F)ccc2F)nc2oc(-c3cc(C)c(OCC(=O)N4CCC[C@H]4C(=O)O)c(C)c3)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130116235A1,Cn1cc(-c2ccnc(N3CCn4c5c(c(F)c4C3=O)CCCC5)c2C=O)nc(Nc2cccnc2)c1=O>>Cn1cc(-c2ccnc(N3CCn4c5c(c(F)c4C3=O)CCCC5)c2CO)nc(Nc2cccnc2)c1=O,,CO,,[BH4-].[Na+],,val
US20130102611A1,Cc1ccc(-c2nc3cccnc3nc2-c2ccccc2)cc1>>Cc1ccc(-c2nc3c(nc2-c2ccccc2)NCCC3)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US20060270713A1,CC(C)(C)OC(=O)N1CCC[C@H](N)C1.O=Cc1ccc(F)cc1C(F)(F)F>>CC(C)(C)OC(=O)N1CC[C@H](NCc2ccc(F)cc2C(F)(F)F)C1,,CO,,[BH4-].[Na+],,val
US05882628,CC1(C)OCC(C(=O)Nc2c(I)c(CCC(=O)[O-])c(I)c(NC(=O)C3COC(C)(C)O3)c2I)O1>>O=C(Nc1c(I)c(CO)c(I)c(NC(=O)C(O)CO)c1I)C(O)CO,,CO,Cl,O,,val
US20100143341A1,CC(C)Nc1ccccc1N.Clc1ncnc2sccc12>>CC(C)Nc1ccccc1Nc1ncnc2sccc12,,CC(C)O,,,,val
US06441236B1,CC(C)(CO)CO.CON=C(C(C)=O)C(C)=O>>CO/N=C(\C(C)=O)C1(C)OCC(C)(C)CO1,,Cc1ccccc1,,O,O=S(=O)(O)O,val
US06174898B1,COC(=O)C1=CCCN(CCOC=C(c2ccccc2)c2ccccc2)C1.Cl>>Cl.O=C(O)C1=CCCN(CCOC=C(c2ccccc2)c2ccccc2)C1,,CCO,,O,[Na+].[OH-],val
US20040067966A1,C=CC12CCC(c3nc4c([nH]3)c(=O)n(CCC)c(=O)n4CCC)(CC1)CO2.O>>CCCn1c(=O)c2[nH]c(C34CCC(C=O)(CC3)OC4)nc2n(CCC)c1=O,,CC(C)(C)O,O,C1COCCO1,,val
US20120202785A1,CCn1c([C@H](C)NC(=O)OC(C)(C)C)nc2ccc(F)c(-c3ccccn3)c21>>CCn1c([C@H](C)N)nc2ccc(F)c(-c3ccccn3)c21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030060467A1,CC1OC(=O)C(C(C)(C)C)=C1O.NN>>CC(O)C1=C(C(C)(C)C)C(=O)N=N1,,CCO,,O,,val
US20120202853A1,Cc1csc(C)c1-c1c(-c2ccc(O)cc2F)nn(C)c1C#N.NO>>Cc1csc(C)c1-c1c(-c2ccc(O)cc2F)nn(C)c1C(=N)NO,,CS(C)=O,,CCOC(C)=O,O,val
US04952722,CC(C)=O.O=Cc1ccc2c(c1)CCC2>>CC(=O)C=Cc1ccc2c(c1)CCC2,,O,,[Na+].[OH-],,val
US20030195332A1,CCOC(=O)Cn1c(N)nc2c(I)nc(C(=O)OCc3ccccc3)nc21>>Nc1nc2c(I)nc(C(=O)OCc3ccccc3)nc2n1CC(=O)O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20020115863A1,CCCC[C@H](CC(=O)OC)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1>>CCCC[C@H](CC(=O)OC)C(=O)N1CCC[C@H]1C(=O)O,[Pd],CCOC(C)=O,,,,val
US20130029973A1,CCCN(c1ccc(C(=O)OC)cn1)S(=O)(=O)c1cccc(C(=O)OCC[Si](C)(C)C)c1>>CCCN(c1ccc(C(=O)OC)cn1)S(=O)(=O)c1cccc(C(=O)O)c1,,C1CCOC1,,Cl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20110077252A1,N#Cc1ccc(N)cn1.O=C(Cl)c1cccs1>>N#Cc1ccc(NC(=O)c2cccs2)cn1,,ClCCl,,CCN(CC)CC,,val
US20020193614A1,COc1cc(CBr)ccc1Cl.O=C1NC(=O)c2ccccc21>>COc1cc(CN2C(=O)c3ccccc3C2=O)ccc1Cl,,CN(C)C=O,,[K],,val
US06172064B2,CC(=O)OC=O.Cc1ccc(CCC[C@@H](C(=O)O)[C@H](C)NOC2CCCCO2)cc1>>Cc1ccc(CCC[C@@H](C(=O)O)[C@H](C)N(C=O)OC2CCCCO2)cc1,,c1ccncc1,,,,val
US20140114068A1,CC(C)c1ccc2c(c1)OC1(O)c3cccc([N+](=O)[O-])c3C(=O)C21NC(=O)c1cc2ccccc2n1C>>CC(C)c1ccc2c(c1)OC1(O)c3cccc(N)c3C(=O)C21NC(=O)c1cc2ccccc2n1C,[Fe],CCO,,Cl,O,val
US20120214803A1,CN(C)c1ccncc1.O=[N+]([O-])c1ccc(C(F)(F)F)cc1S(=O)(=O)Cl.c1ccncc1>>O=[N+]([O-])c1ccc(C(F)(F)F)cc1S(=O)(=O)Nc1cccc2cccnc12,CN(C)c1ccncc1,ClCCl,,,,val
US20060211734A1,CN1CCC(Sc2cccc(N)c2)CC1.ClCCl.O=C(Cl)c1ccc(F)cc1Cl>>CN1CCC(Sc2cccc(NC(=O)c3ccc(F)cc3Cl)c2)CC1.Cl,,ClCCl,,c1ccncc1,,val
US20130158025A1,COc1ccc(B(O)O)cc1.Cc1cccc(-c2cc(N3CCC[C@H]3CO)nc3c(I)c(C)nn23)c1>>COc1ccc(-c2c(C)nn3c(-c4cccc(C)c4)cc(N4CCC[C@H]4CO)nc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])O.[Na+],val
US04279918,CC(=O)Cl.CN1CCCC1Cc1ccc(N)cc1>>CC(=O)Nc1ccc(CC2CCCN2C)cc1,,CCOCC,c1ccccc1,CCN(CC)CC,O,val
US20150241439A1,C1CCNCC1.CC(=O)O.CC(C)[Si](OC1CCCCc2cc(C=O)c(O)cc2C1)(C(C)C)C(C)C.CCO.CCOC(=O)CC(=O)OCC>>CCOC(=O)c1cc2cc3c(cc2oc1=O)CC(O[Si](C(C)C)(C(C)C)C(C)C)CCCC3.O=c1ccc2ccccc2o1,,CCO,,,,val
US06124323,COC(=O)c1cc(OCCOCc2ccccc2)ccc1[N+](=O)[O-]>>O=C(O)c1cc(OCCOCc2ccccc2)ccc1[N+](=O)[O-],,CO,,[Li+].[OH-],,val
US05563141,CS(=O)(=O)Cl.O=C(OCc1ccccc1)N1CCC(CO)CC1>>CS(=O)(=O)OCC1CCN(C(=O)OCc2ccccc2)CC1,,ClCCl,,,,val
US20100216803A1,COC(=O)[C@H]1CCC[C@H]1NC(=O)OC(C)(C)C.Cl>>COC(=O)[C@H]1CCC[C@H]1N.Cl,,CCOC(C)=O,,,,val
US20160031852A1,CNc1ccccc1C(=O)OC.N#CO[K]>>Cn1c(=O)[nH]c(=O)c2ccccc21,,O,,CC(=O)O,,val
US20080039457A1,COC(=O)c1ccc(-c2cnc(S(C)=O)nn2)cc1F.NN>>COC(=O)c1ccc(-c2cnc(NN)nn2)cc1F,,C1CCOC1,,O,,val
US20150018546A1,CCOC(=O)c1c(NCCc2ccccc2)c2cncnc2n(OCc2ccccc2)c1=O>>O=c1cc(NCCc2ccccc2)c2cncnc2n1OCc1ccccc1,,CO,,[Na+].[OH-],,val
US20090054417A1,Cc1cc(-c2cccc(COS(C)(=O)=O)c2)cc2c1OCC(=O)N2.c1cn[nH]c1>>Cc1cc(-c2cccc(Cn3cccn3)c2)cc2c1OCC(=O)N2,,CN(C)C=O,,,,val
US20130053359A1,COc1cc(NC(=O)OCCN(C)[C@@H]2CC[C@@H](OC(=O)C(O)(c3cccs3)c3cccs3)CC2)c(Cl)cc1CO[Si](C)(C)C(C)(C)C>>COc1cc(NC(=O)OCCN(C)[C@@H]2CC[C@@H](OC(=O)C(O)(c3cccs3)c3cccs3)CC2)c(Cl)cc1CO,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20080312255A1,COC(=O)c1sc(Cl)nc1C(=O)/C=C/N(C)C.NN>>COC(=O)c1sc(Cl)nc1-c1ccn[nH]1,,CC(=O)O,,Cl,,val
US04181802,C=C(C)n1c(=O)[nH]c2ccccc21.ClCC1CCN(Cc2ccccc2)C1>>O=c1[nH]c2ccccc2n1CC1CCN(Cc2ccccc2)C1,,CN(C)C=O,,[H-].[Na+],,val
US05716936,COC(=O)c1cccc(NC(=O)NCC(=O)N2C(C(=O)NCC(C)C)CC(S(=O)(=O)c3cccc(OC)c3)C2c2ccccc2F)c1>>O=C(O)c1ccccc1,,CO,O,[K+].[OH-],,val
US20100204196A1,COc1ccc(N(C)C(=O)CN(C)C)cc1N.Cc1ccc(S(=O)(=O)n2ccc3c2nc(Cl)n2c(=O)c4c(F)cccc4nc32)cc1>>COc1ccc(N(C)C(=O)CN(C)C)cc1Nc1nc2c(ccn2S(=O)(=O)c2ccc(C)cc2)c2nc3cccc(F)c3c(=O)n12,,C1CCOC1,,,,val
US20120225867A1,COCCN.C[C@@H](Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1)NC(=O)c1csc(Br)n1>>COCCNc1nc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3)n2)cs1,,c1ccncc1,,,,val
US20100144700A1,CC(C)(C)OC(=O)N1CC2CNCCC21.O=C(Cl)c1ccoc1>>CC(C)(C)OC(=O)N1CC2CN(C(=O)c3ccoc3)CCC21,,ClCCl,,CCN(CC)CC,,val
US05643878,C=CC(N)Cc1ccc(C(F)(F)F)cc1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=CC(Cc1ccc(C(F)(F)F)cc1)NC(=O)OC(C)(C)C,,ClCCl,,,,val
US20130281710A1,Cc1c(S(=O)C(F)(F)F)c(C(N)=O)nn1-c1c(F)cc(C(F)(F)F)cc1Cl>>Cc1c(S(=O)C(F)(F)F)c(C#N)nn1-c1c(F)cc(C(F)(F)F)cc1Cl,,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20080146614A1,Cc1c(C(=O)O)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(OCc2ccccc2)cc1.NC1CCC(F)(F)CC1>>Cc1c(C(=O)NC2CCC(F)(F)CC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(OCc2ccccc2)cc1,,O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20030199510A1,Cc1cccc2c1CCC2=O.O=C1Cc2ccccc2N1>>Cc1cccc2c1CCC2=C1C(=O)Nc2ccccc21,,CN(C)C=O,,C1CCNCC1,Cl,val
US20070027126A1,CCS(=O)(=O)Cl.Cn1c(C#N)ccc1-c1ccc(N)c(F)c1>>CCS(=O)(=O)Nc1ccc(-c2ccc(C#N)n2C)cc1F,,CCOC(C)=O,c1ccncc1,O,,val
US20160244451A1,COC(=O)c1cc(F)c(NS(=O)(=O)c2ccc(-c3cnc(C4CCN(C(=O)OC(C)(C)C)CC4)nc3)cc2)cc1F>>CC(C)(C)OC(=O)N1CCC(c2ncc(-c3ccc(S(=O)(=O)Nc4cc(F)c(C(=O)O)cc4F)cc3)cn2)CC1,,CO,,Cl,[Li+].[OH-],val
US20050107364A1,C=CCC1(C)C(OC)=CC(=O)c2ccccc21>>C=CCC1(C)C(=O)C=C(O)c2ccccc21,,CO,,Cl,[Na+].[OH-],val
US20120129806A1,CCOC(=O)N1Cc2cc(Cl)ccc2CC1C(=O)OC.Cl>>Cl.O=C(O)C1Cc2ccc(Cl)cc2CN1,,Cl,,,,val
US04056544,NC1CCCCC1.O=C1c2cccc([N+](=O)[O-])c2C(=O)c2c1cccc2[N+](=O)[O-]>>O=C1c2cccc(NC3CCCCC3)c2C(=O)c2c1cccc2[N+](=O)[O-],,O=[N+]([O-])c1ccccc1,,,,val
US20050004369A1,CC1(C)OC(=O)C(CC(=O)c2ccc(-c3ccc(-c4c(Cc5ccccc5)oc5ccccc45)cc3)cc2)C(=O)O1>>O=C(O)CCC(=O)c1ccc(-c2ccc(-c3c(Cc4ccccc4)oc4ccccc34)cc2)cc1,,C1CCOC1,,Cl,,val
US04861916,CC(=O)OCCOc1ccc(C(=O)c2ccccc2)cc1>>O=C(c1ccccc1)c1ccc(OCCO)cc1,,CCO,,Cl,[Na+].[OH-],val
US20160083343A1,O=Cc1c(O)cccc1O.O=S(=O)(c1ccccc1)N1CCC[C@H]1CO>>O=Cc1c(O)cccc1OC[C@@H]1CCCN1S(=O)(=O)c1ccccc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050054851A1,CC(C)(C)Cn1c(CN2CCN(C(=O)O)CC2)cc2cnc(C#N)nc21>>CC(C)(C)Cn1c(CN2CCNCC2)cc2cnc(C#N)nc21,,CCOCC,,C1COCCO1,Cl,val
US20130023514A1,CCOC(=O)[C@@H]1CC[C@@H](N(Cc2ccccc2)Cc2ccccc2)CC1>>O=C(O)[C@@H]1CC[C@@H](N(Cc2ccccc2)Cc2ccccc2)CC1,,C1CCOC1,O,[Li+].[OH-],,val
US20030153604A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)CCNC1CCN(c2ccc(C(=O)O)cc2)CC1>>CN(C)CCN(C(=O)OC(C)(C)C)C1CCN(c2ccc(C(=O)O)cc2)CC1,,C1CCOC1,O,,,val
US20110152273A1,COc1ccc(CN2Cc3c(F)c(N[C@H](CC(C)C)C(N)=O)nc(-c4ccco4)c3C2=O)c(OC)c1>>CC(C)C[C@@H](Nc1nc(-c2ccco2)c2c(c1F)CNC2=O)C(N)=O,,O=C(O)C(F)(F)F,,,,val
US04933453,Fc1ccc(-n2cc(N3CCNCC3)c3ccccc32)cc1.O=C1N(CCCCBr)CSC12CCCCC2>>O=C1N(CCCCN2CCN(c3cn(-c4ccc(F)cc4)c4ccccc34)CC2)CSC12CCCCC2,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20040029859A1,COc1cc(F)c(C#N)c(F)c1.OC1CCOC1>>COc1cc(F)c(C#N)c(OC2CCOC2)c1,,C1CCOC1,,O,[H-].[Na+],val
US20020107251A1,COC(=O)C(=O)Cl.Nc1cccc(-n2c(=O)c(Cc3ccccc3)nc3cccnc32)c1>>CON(C(=O)C=O)c1cccc(-n2c(=O)c(Cc3ccccc3)nc3cccnc32)c1,,CCOC(C)=O,ClCCl,CCN(CC)CC,O=C([O-])O.[Na+],val
US20090131379A1,C=C1[C@H](O[Si](C)(C)C(C)(C)C)CC(=O)C[C@H]1O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.COC(=O)C[Si](C)(C)C>>C=C1[C@H](O)C/C(=C/C(=O)OC)C[C@H]1O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20150065515A1,CC(C)[C@@H](NC(=O)OCc1ccccc1)C(=O)O.COC(C)(CN)OC>>COC(CNC(=O)[C@H](NC(=O)OCc1ccccc1)C(C)C)OC,,C1CCOC1,,CN1CCOCC1,,val
US20030127020A1,NC(=O)c1ccccc1O.OB(O)O.OCC(O)CO>>NC(=O)c1ccccc1O.OCC(O)COB(O)O,,Cc1ccccc1,,,,val
US20060025614A1,CCOC(=N)Cc1ccccc1C.N#CN>>CCOC(Cc1ccccc1C)=NC#N,,CCO,CCOCC,Cl,,val
US04721820,C=CCCCC(C=C)OC>>C=CCCCC=CCOC,Cl[Pd]Cl,,,CO,,val
US20130252937A1,Cc1c(C#N)cccc1-c1ccc(F)c2c1CC[C@H]2Oc1ccc2c(c1)OC[C@H]2CC(=O)O.OO>>Cc1c(C(N)=O)cccc1-c1ccc(F)c2c1CC[C@H]2Oc1ccc2c(c1)OC[C@H]2CC(=O)O,,CCO,,N,,val
US20080070898A1,O=C(CCl)N1CCC(/C=C/c2ccc(Cl)cc2)CC1.OC1CCCNC1>>O=C(CN1CCCC(O)C1)N1CCC(/C=C/c2ccc(Cl)cc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04036850,Nc1ccc([N+](=O)[O-])cc1.O=C=NC(=O)C(Br)CBr>>O=C(NC(=O)C(Br)CBr)Nc1ccc([N+](=O)[O-])cc1,,CC#N,,,,val
US20140200216A1,CC(C)(C)OC(=O)N[C@H]1C[C@@H](C(F)(F)F)CN(c2ccncc2N)C1.CN1CCN(c2ccc3cc(NC(=O)OCc4ccccc4)c(C(=O)O)nc3c2)CC1>>CN1CCN(c2ccc3cc(NC(=O)OCc4ccccc4)c(C(=O)Nc4cnccc4N4C[C@H](C(F)(F)F)C[C@H](NC(=O)OC(C)(C)C)C4)nc3c2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160185752A1,Clc1ccc(C2CCCNC2)cc1>>Clc1ccc([C@H]2CCCNC2)cc1,,CCO,,,,val
US20090088451A1,C=C[Sn](CCCC)(CCCC)CCCC.COc1ccccc1CNc1ccc2cc(Br)ccc2n1>>C=Cc1ccc2nc(NCc3ccccc3OC)ccc2c1,,Cc1ccccc1,,,,val
US05614527,CC=CN1CCN(CC2CCOC2)C1=N[N+](=O)[O-]>>O=[N+]([O-])N=C1NCCN1CC1CCOC1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20140371199A1,CN1CCN(Cc2ccc(N)cc2)CC1.N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)O)cc4)cn23)cc1>>CN1CCN(Cc2ccc(NC(=O)c3ccc(-c4ccc5ncc(-c6ccc(C#N)cc6)n5c4)cc3)cc2)CC1,,CN(C)C=O,O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US03983111,BrBr.CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C>>C[C@]12CC(=O)[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CBr,,CO,,,,val
US06184225B2,CCOC(=O)c1ccc(O)c(OC)c1.COCCBr>>CCOC(=O)c1ccc(OCCOC)c(OC)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130261327A1,CCOC(=O)/C=C/CP(=O)(OCC)OCC>>CCOP(=O)(C/C=C/C(=O)O)OCC,,O,,[K+].[OH-],,val
US20120302539A1,CC(C)(C)OC(=O)NC1CCNCC1.CS(=O)(=O)OCc1ccc(NC(=O)OCc2ccccc2)cc1>>CC(C)(C)OC(=O)NC1CCN(Cc2ccc(NC(=O)OCc3ccccc3)cc2)CC1,,CN(C)C=O,,O=C([O-])O.[K+],,val
US20090131461A1,CC(=O)Cl.COc1cc2c(Oc3ccc(NC(=O)c4ccccc4)cc3)ccnc2cc1OCC[C@H](N)C(=O)OC1CCCC1>>COc1cc2c(Oc3ccc(NC(=O)c4ccccc4)cc3)ccnc2cc1OCC[C@H](NC(C)=O)C(=O)OC1CCCC1,,ClCCl,,CCN(CC)CC,,val
US20150336986A1,CC(C)(C)[Si](C)(C)Cl.Cn1c(=O)c2c(-c3ccccc3)n(CC(O)CO)cc2n(C)c1=O>>Cn1c(=O)c2c(-c3ccccc3)n(CC(O)CO[Si](C)(C)C(C)(C)C)cc2n(C)c1=O,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4c(Cl)c(F)ccc4nn23)CC1.Cl>>Cl.O=c1cc(C2CCNCC2)n2nc3ccc(F)c(Cl)c3c2[nH]1,,C1COCCO1,,,,val
US20120108801A1,C1CCNC1.C[Si](C)(C)Cl>>C[Si](C)(C)N1CCCC1,,CCOCC,,,,val
US20120264731A1,O=C(c1cc(C2C=CCN2)c2oc(N3CCOCC3)cc(=O)c2c1)N1CCOCC1>>O=C(c1cc(C2CCCN2)c2oc(N3CCOCC3)cc(=O)c2c1)N1CCOCC1,[Pd],CO,,,,val
US04602019,O=C(O)CC1Cc2cc(F)ccc2C1=O.c1c[nH]cn1>>O=C(O)CC1Cc2cc(-n3ccnc3)ccc2C1=O,,c1ccncc1,,O=C([O-])[O-].[K+].[K+],,val
US20150291572A1,O=C(O)c1cc(=O)cco1>>O=C1CCOC(C(=O)O)C1,[Pd],CCOC(C)=O,,,,val
US20120329808A1,CC1SCc2ncnc(Cl)c21.C[C@H]1CN(C(=O)OC(C)(C)C)CCN1>>CC1SCc2ncnc(N3CCN(C(=O)OC(C)(C)C)C[C@@H]3C)c21,,CCOC(C)=O,CN1CCCC1=O,CCN(C(C)C)C(C)C,,val
US20060063739A1,C1COCCN1.CN1N=C(Cl)C=C(Cl)N1>>CN1N=C(Cl)C=C(N2CCOCC2)N1,,ClCCl,,,,val
US20150018343A1,Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1C=C1CCN(C(=O)OC(C)(C)C)CC1)C3>>Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1C=C1CCNCC1)C3,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090054453A1,Cc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)c2c1CC[C@@H](N)C2.O=S(=O)(Cl)c1c(Cl)cccc1Cl>>Cc1ccc(N2CCNCC2)c2c1CC[C@@H](NS(=O)(=O)c1c(Cl)cccc1Cl)C2,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140287984A1,C=CCOC(=O)[C@H](Cc1ccc(OC(=O)NCCC(C(=O)O)N(C)C(=O)OC(C)(C)C)cc1)NC(=O)OC(C)(C)C.NC(=O)[C@@H](N)CSC(c1ccccc1)(c1ccccc1)c1ccccc1>>C=CCOC(=O)[C@H](Cc1ccc(OC(=O)NCCC(C(=O)N[C@@H](CSC(c2ccccc2)(c2ccccc2)c2ccccc2)C(N)=O)N(C)C(=O)OC(C)(C)C)cc1)NC(=O)OC(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110212053A1,CC(C)(C#N)c1ccc(CC(=O)c2cc(Br)ccc2/N=C/C[N+](=O)[O-])cc1>>CC(C)(C#N)c1ccc(Cc2c([N+](=O)[O-])cnc3ccc(Br)cc23)cc1,,CCO,,CC(=O)[O-].[K+],,val
US20080293716A1,Nc1ccccc1Cl.O=C(Cl)c1ccc(Br)s1.OB(O)c1ccncc1>>O=C(Nc1ccccc1Cl)c1ccc(-c2ccncc2)s1,[Pd],,,,,val
US20060142265A1,C=CC(=O)Cl.CCCOc1c(CCN)cccc1OC>>C=CC(=O)N(C)Cc1cccc(OC)c1OCCC,,ClCCl,,CCN(CC)CC,,val
US20120214803A1,Nc1cccc2cccnc12.O=S(=O)(Cl)c1ccc(Cl)cc1F>>O=S(=O)(Nc1cccc2cccnc12)c1ccc(Cl)cc1F,CN(C)c1ccncc1,,,,,val
US05028606,CC(=O)Nc1ccc(C=O)cc1.CCCBr>>CCCC(O)c1ccc(NC(C)=O)cc1,,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US05077288,Cl.O=C(c1ccc(F)cc1)C1CCN(CCCCl)CC1.O=C1CN(Cc2ccccn2)CC(=O)N1>>Cl.O=C(c1ccc(F)cc1)C1CCN(CCCN2C(=O)CN(Cc3ccccn3)CC2=O)CC1,,CCO,CN(C)C=O,[H-].[Na+],,val
US08088793B2,CN(C(=O)NCc1cccc(F)c1Cl)[C@@H](CCCN)COC(=O)Nc1cc2cc(F)ccc2cn1.N#CN=C(Oc1ccccc1)Oc1ccccc1>>CN(C(=O)NCc1cccc(F)c1Cl)[C@@H](CCCN/C(=N/C#N)Oc1ccccc1)COC(=O)Nc1cc2cc(F)ccc2cn1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20030036651A1,CCOC(=O)CP(=O)(OCC)OCC.O=Cc1ccccn1>>CCOC(=O)C=Cc1ccccn1,,C1CCOC1,O,CC(=O)O,[H-].[Na+],val
US20110053933A1,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(O)CC1.Fc1cnc(Cl)nc1>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(Oc2ncc(F)cn2)CC1,,O,,CN(C)C=O,[H-].[Na+],val
US20110130380A1,C[C@H](N)C1CCOCC1.Fc1cccc(Br)n1>>C[C@H](Nc1cccc(Br)n1)C1CCOCC1,,O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20140228396A1,Cc1cc(C)c(S(=O)(=O)ON)c(C)c1.Nc1cc(F)c(F)cn1>>Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1.Nc1cc(F)c(F)c[n+]1N,,ClCCl,,,,val
US04526979,COC(=O)Cl.Nc1ccccc1C(=O)Nc1nnn[nH]1>>COC(=O)Nc1ccccc1C(=O)Nc1nnn[nH]1,,CN(C)C=O,O,,,val
US20020103335A1,N[C@H]1CCCNC(=O)C1.O=C(Cl)OCc1ccccc1>>O=C1C[C@@H](NC(=O)OCc2ccccc2)CCCN1,,C1CCOC1,,CCN(CC)CC,O,val
US20110092475A1,OC(c1ccccc1)c1cnc(C#Cc2ccccc2)s1>>O=C(c1ccccc1)c1cnc(C#Cc2ccccc2)s1,,CCOC(C)=O,ClCCl,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20140080798A1,CC(C)(C)OC(=O)N1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccc(C(F)(F)F)cc4CC(N)=O)n3)cc2)CC1>>NC(=O)Cc1cc(C(F)(F)F)ccc1CCc1nc(Nc2ccc(C3CCNCC3)cc2)ncc1C(F)(F)F,,ClCCl,,O=C(O)C(F)(F)F,,val
US03998834,COC(=O)C1(Nc2cccc(OC)c2)CCN(Cc2ccccc2)CC1>>COC(=O)C1(Nc2cccc(OC)c2)CCNCC1,[Pd],CCO,,[H][H],,val
US20080096877A1,C1CSCCN1.COCCOc1cc(N(C)S(=O)(=O)c2ccccn2)c2[nH]c(C(=O)NCC(C)(C=O)SCc3ccccc3)cc2c1>>COCCOc1cc(N(C)S(=O)(=O)c2ccccn2)c2[nH]c(C(=O)NCC(C)(CN3CCSCC3)SCc3ccccc3)cc2c1,,ClCCCl,,O=C([O-])O.[Na+],,val
US20090186879A1,COc1nc(C)nc(OC)c1N1CCCn2c1nc1c(Cl)ccc(C=O)c12.C[Si](C)(C)C(F)(F)F>>COc1nc(C)nc(OC)c1N1CCCn2c1nc1c(Cl)ccc(C(O)C(F)(F)F)c12,,C1CCOC1,CCOC(C)=O,Cl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20050143422A1,CCOC(=O)c1oc2cccc(NC(=O)OC(C)(C)C)c2c1C>>CCOC(=O)c1oc2cccc(N)c2c1C,,ClCCCl,,O=C(O)C(F)(F)F,,val
US05936000,CC(=O)OCc1cc2c(cc1COC(C)=O)CC(NC(=O)C(F)(F)F)C2>>NC1Cc2cc(CO)c(CO)cc2C1,,CO,O,[K+].[OH-],,val
US20050085484A1,Nc1cccc(-c2cn3ccnc3c(NCc3ccncc3)n2)c1.O=C=Nc1cccc(C(F)(F)F)c1>>O=C(Nc1cccc(-c2cn3ccnc3c(NCc3ccncc3)n2)c1)Nc1cccc(C(F)(F)F)c1,,Cc1ccccc1,,,,val
US20040010007A1,Cc1nc(Cl)c([N+](=O)[O-])c(Cl)c1C.NCCOc1ccccc1>>Cc1nc(Cl)c([N+](=O)[O-])c(NCCOc2ccccc2)c1C,,CCN(CC)CC,,CN(C)C=O,,val
US20150376130A1,COC(=O)c1cc(F)ccc1NCCC(F)(F)F>>O=C(O)c1cc(F)ccc1NCCC(F)(F)F,,C1CCOC1,,[Na+].[OH-],,val
US20090181943A1,C[S+](C)(C)=O.O=C(c1ccccc1)C1CCN(C(=O)OCc2ccccc2)CC1>>O=C(OCc1ccccc1)N1CCC(C2(c3ccccc3)CO2)CC1,,C1CCOC1,,[H-].[Na+],,val
US20080085890A1,CN1CCN(c2ccc(N)cc2)CC1.COC=C1C(=O)NC(=O)c2ccccc21>>CN1CCN(c2ccc(N/C=C3\CN=Cc4ccccc43)cc2)CC1,,CN(C)C=O,,,,val
US20110028493A1,COC(=O)c1ccc(CC(N)=S)cc1.O=C(CBr)c1cccc(C(F)(F)F)c1F>>COC(=O)c1ccc(Cc2nc(-c3cccc(C(F)(F)F)c3F)cs2)cc1,,CO,,,,val
US20100093788A1,C=C1CCCCC1.CCOC(=O)C[N+](=O)[O-]>>CCOC(=O)C1=NOC2(CCCCC2)C1,,CCO,,C1CN2CCN1CC2,,val
US20110003787A1,COC[C@H](C)Oc1cc(O)cc(-c2ccc(C3=N[C@H](C)CO3)[nH]2)c1.CS(=O)(=O)c1cnc(Br)cn1>>COC[C@H](C)Oc1cc(Oc2cnc(S(C)(=O)=O)cn2)cc(-c2ccc(C3=N[C@H](C)CO3)[nH]2)c1,,CC#N,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150307477A1,CNc1nc(-c2cccnc2)nc2c(C)cc(Br)cc12.COc1cccc(B(O)O)c1>>CNc1nc(-c2cccnc2)nc2c(C)cc(-c3cccc(OC)c3)cc12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US03947466,C=O.CC#N.NCc1nnc2n1-c1ccc(Cl)cc1C(c1c(F)cccc1F)=NC2>>CN(C)Cc1nnc2n1-c1ccc(Cl)cc1C(c1c(F)cccc1F)=NC2,,CC#N,,CC(=O)O,[BH3-]C#N.[Na+],val
US20070037829A1,CC(C)(C)[Si](C)(C)Cl.CCOC(=O)[C@@H]1CC[C@H](O)CC1>>CCOC(=O)[C@@H]1CC[C@H](O[Si](C)(C)C(C)(C)C)CC1,,O,,CN(C)C=O,c1c[nH]cn1,val
US20050187247A1,COc1cc2c(Cl)c(C#N)cnc2cc1OCCCCl.Cn1ccnc1Sc1ccc(N)cc1Cl>>COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1OCCCCl,,CCOCCO,,Cl,c1ccncc1,val
US20130065861A1,CCCCCCCCCCCC(=O)OC[C@H](CSC[C@H](N)C(=O)N[C@@H](C)COCCCP(=O)(OCC)OCC)OC(=O)CCCCCCCCCCC>>CCCCCCCCCCCC(=O)OC[C@H](CSC[C@H](N)C(=O)N[C@@H](C)COCCCP(=O)(O)O)OC(=O)CCCCCCCCCCC,,ClCCl,,C[Si](C)(C)Br,,val
US20040006114A1,CCS(=O)(=O)Cl.Nc1cccnc1>>CCS(=O)(=O)N1C=CC=C(N)C1,,ClCCl,,,,val
US20090163508A1,Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.Fc1ccc(-c2cc(N3CCNCC3)ncn2)c(F)c1>>Cc1noc(NC(=O)N2CCN(c3cc(-c4ccc(F)cc4F)ncn3)CC2)c1C,,CCCCCC,CCOC(C)=O,,,val
US20110144100A1,CC(C)(C)[Si](C)(C)Oc1cccc2ccc(C=O)nc12.COCCOc1ccnc(NN)c1>>COCCOc1ccnc(N/N=C/c2ccc3cccc(O[Si](C)(C)C(C)(C)C)c3n2)c1,,CCO,,,,val
US20130096112A1,CC(=O)c1ccc(O)cc1O.CCOC(OCC)OCC>>O=c1ccoc2cc(O)ccc12,,CCOCC,,[O-][Cl+3]([O-])([O-])O,,val
US20030013704A1,CC(C)(C)OC(=O)NCCc1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1>>NCCc1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1,,CO,ClCCl,,,val
US04990517,C=CCN(CC(C)=O)C(C)=O.CNO>>CC(=O)N1CC2CON(C)C2(C)C1,,C1COCCO1,O,Cl,CC(=O)[O-].[Na+],val
US20120277217A1,CI.Oc1ccc(Cl)c(F)c1>>COc1ccc(Cl)c(F)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20040082779A1,Cc1cc(Br)cc2ccsc12.O=C1CCC(=O)N1Br>>BrCc1cc(Br)cc2ccsc12,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US04076712,Cc1ccc(C(=O)O)c(Cl)n1.Nc1ccn[nH]1>>Cc1ccc2c(=O)n3nccc3[nH]c2n1,,CO,,,,val
US20120028800A1,CC(C)(C)C(=O)Cl.Cc1cc(OCc2ccccc2)cc(C)c1C1C(=O)C2C3CCC(CC3)C2C1=O>>Cc1cc(OCc2ccccc2)cc(C)c1C1=C(OC(=O)C(C)(C)C)C2C3CCC(CC3)C2C1=O,,ClCCl,,CCN(CC)CC,,val
US20100137303A1,CN(C)CCOc1ncc(N)cc1Br.COc1ncc(B(O)O)cn1>>COc1ncc(-c2cc(N)cnc2OCCN(C)C)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20160194302A1,CN(C)C1CCN(C(=O)CCc2nccn2CC(=O)OC2CC2)CC1.Cl>>CN(C)C1CCN(C(=O)CCc2nccn2CC(=O)OC2CC2)CC1.Cl,,CCOCC,,,,val
US20050014804A1,CC(C)(C)OC(=O)NCC1(C#N)CC12CCCCC2.NO>>CC(C)(C)OC(=O)NCC1(C(=N)NO)CC12CCCCC2,,CCO,,,,val
US20090298807A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12.O=CCCCCCCCCBr>>CC(C)(C)OC(=O)N(CCCCCCCCCBr)C[C@H](O)c1ccc(O)c2[nH]c(=O)sc12,,CC(=O)O,CN(C)C=O,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20160237075A1,C=CC(=O)Cl.NC(=O)c1ccc(C2CCNCC2)nc1-c1ccc(Oc2ccccc2)cc1>>C=CC(=O)N1CCC(c2ccc(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)n2)CC1,,ClCCl,,,,val
US20080096860A1,C[C@H](COC(c1ccccc1)(c1ccccc1)c1ccccc1)Oc1cc(NS(=O)(=O)N2CCN(C)CC2)nc(SCc2cccc(F)c2F)n1>>C[C@H](CO)Oc1cc(NS(=O)(=O)N2CCN(C)CC2)nc(SCc2cccc(F)c2F)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040097498A1,CCCOc1ccc(N)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1.N#Cc1cccc(S(=O)(=O)Cl)c1>>CCCOc1ccc(NS(=O)(=O)c2cccc(C#N)c2)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1,,C1CCOC1,,c1ccncc1,,val
US05041673,CCOCC(O)(COCC)C(Cc1ccc2ccccc2c1)[N+](=O)[O-]>>CCOCC(O)(COCC)C(N)Cc1ccc2ccccc2c1,[Ni],CC(C)O,,,,val
US20130123268A1,CC(C)(C)OC(=O)N1C2CCC1CC(O)(c1ccccn1)C2>>OC1(c2ccccn2)CC2CCC(C1)N2,,ClCCl,O=C(O)C(F)(F)F,,,val
US04046908,Nc1ccc(SCC2CC2(Cl)Cl)cc1[N+](=O)[O-]>>Nc1ccc(SCC2CC2(Cl)Cl)cc1N,O=[Pt]=O,CCO,,,,val
US20090181967A1,CC(C)(C)OC(=O)N1CCOCC1CO>>CN1CCOCC1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04186199,c1ccc(C2=Nc3ccccc3N3CCc4cccc2c43)cc1>>c1ccc(C2Nc3ccccc3N3CCc4cccc2c43)cc1,,CCO,,O,[BH4-].[Na+],val
US20110301143A1,CCOC(=O)Cn1nnc(-c2cnc(N3CCN(C(=O)c4cccc(F)c4C(F)(F)F)CC3)s2)n1>>O=C(O)Cn1nnc(-c2cnc(N3CCN(C(=O)c4cccc(F)c4C(F)(F)F)CC3)s2)n1,,C1CCOC1,,[Li+].[OH-],,val
US20120172448A1,BrC1CCCC1.CCOC(=O)Cc1ccc([N+](=O)[O-])cc1>>CCOC(=O)C(c1ccc([N+](=O)[O-])cc1)C1CCCC1,,CN(C)C=O,,O,CC(C)(C)[O-].[K+],val
US06656469B1,COC(=O)c1ccc(C#Cc2cncc(C3CCCN3C)c2)cc1>>COC(=O)c1ccc(CCc2cncc(C3CCCN3C)c2)cc1,,CO,,,,val
US20100298336A1,BrP(Br)Br.OCc1cnc2ccccc2c1>>BrCc1cnc2ccccc2c1,,ClCCl,,,,val
US06169086A,Nc1nc(Cl)cc(Cl)n1.OCc1ccccc1>>Nc1nc(Cl)cc(OCc2ccccc2)n1,,C1CCOC1,,[H-].[Na+],,val
US20070066624A1,N#Cc1ccc(Oc2ccc(CBr)cn2)cc1.O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCNCC1>>N#Cc1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cn2)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080221163A1,CC(C)Oc1cc(F)ccc1Br.SCc1ccccc1>>CC(C)Oc1cc(SCc2ccccc2)ccc1Br,,CN(C)C=O,ClCCl,[H-].[Na+],,val
US05385692,CCCCCCCCC1Cc2ccc(C(=O)Cl)cc2C1.NCC(=O)O>>CCCCCCCCC1Cc2ccc(C(=O)NCC(=O)O)cc2C1,,C1COCCO1,O,Cl,[Na+].[OH-],val
US05703125,CC(C)COC(=O)Cl.CN(C)c1ccccn1.CN1CCOCC1.NN=Cc1ccc(NC(=O)CCC(=O)O)cc1>>CCOC(=O)CC(C)NC(=O)CCC(=O)Nc1ccc(C=NN)cc1,,CN(C)C=O,,Cl,,val
US20090143448A1,CCc1nc(N)sc1Br.Cc1cc(S(N)(=O)=O)cs1.O=C(Cl)Oc1ccccc1>>CCc1nc(NC(=O)NS(=O)(=O)c2csc(C)c2)sc1Br,,CC#N,,CCN(CC)CC,,val
US20050096345A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1[nH]nc2c1CCN(c1ccc([N+](=O)[O-])cn1)C2>>CCOC(=O)c1[nH]nc2c1CCN(c1ccc(NC(=O)OC(C)(C)C)cn1)C2,[Pd],CO,,[H][H],,val
US04183933,C=Cc1cnccn1.CCN>>CCNCCc1cnccn1,,CO,O,CC(=O)O,[Na+].[OH-],val
US20080269196A1,CC1(C)CCCC(Oc2ccc(C#N)cn2)C1>>CC1(C)CCCC(Oc2ccc(CN)cn2)C1,,C1CCOC1,,B,Cl,val
US20110015181A1,CON(C)C(=O)C(C)NC(=O)OC(C)(C)C>>CC(C=O)NC(=O)OC(C)(C)C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20070276011A1,Nc1ccc(CN2C(=O)CSC2=O)cc1.O=C(Cl)COc1ccccc1>>O=C(COc1ccccc1)Nc1ccc(CN2C(=O)CSC2=O)cc1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20120329826A1,Nc1ncc2[nH]ccc2c1Br.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1c1ncc2[nH]ccc2c1Br,,CC(=O)O,,,,val
US20140066627A1,Brc1ccc(I)nc1.CC1(C)OB(c2ccc(N(c3ccccc3)c3cccc4ccccc34)cc2)OC1(C)C>>Brc1ccc(-c2ccc(N(c3ccccc3)c3cccc4ccccc34)cc2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20030069419A1,Cc1ccc(S(=O)(=O)O)cc1.FC(F)(F)c1ccc(/C=C/c2nc(COc3ccc(CCCCn4ccnn4)cc3)co2)cc1>>Cc1ccc(S(=O)(=O)O)cc1.FC(F)(F)c1ccc(/C=C/c2nc(COc3ccc(CCCCn4ccnn4)cc3)co2)cc1,,C1CCOC1,CCOC(C)=O,O,,val
US20050107339A1,CCOc1cc(C(O)c2ccc(N(C)C)cc2)ccc1OC>>CCOc1cc(C(=O)c2ccc(NC)cc2)ccc1OC,O=[Mn]=O,ClCCl,,,,val
US20130190249A1,CC(C)(C)OC(=O)NC1CC(F)(F)C1>>O=CNC1CC(F)(F)C1,,CO,,CC(=O)Cl,,val
US20100298325A1,CC(C)OB(OC(C)C)OC(C)C.CN1CCN(c2cccc(Br)c2)CC1>>CN1CCN(c2cccc(B(O)O)c2)CC1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US05952350,Brc1cccc(OCc2ccccc2)c1.CCCOB(OCCC)OCCC>>OB(O)c1cccc(OCc2ccccc2)c1,,C1CCOC1,,[Li]CCCC,,val
US20110306607A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.COC(=O)c1ccc(-n2cccc2)c(O)c1>>COC(=O)c1ccc2c(c1)OC1(CCN(C(=O)OC(C)(C)C)CC1)c1cccn1-2,,ClCCl,,O=C(O)C(F)(F)F,,val
US04855430,C1CC2CCC1CNC2.CCC(Cl)N1CCN(c2cccc(Cl)c2)CC1.Cl>>Cl.Cl.Clc1cccc(N2CCN(CCCN3CC4CCC(CC4)C3)CC2)c1,,CN(C)C=O,,CCN(CC)CC,O=C([O-])[O-].[Na+].[Na+],val
US20130324579A1,Cc1ccc(S(=O)(=O)Cl)cc1.Cc1cccc(-c2ocnc2C(=O)Nc2cnn(CCO)c2)c1>>Cc1ccc(S(=O)(=O)OCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)cc1,,ClCCl,,CCN(CC)CC,,val
US04894302,BrB(Oc1ccccc1)Oc1ccccc1.C1CCOC1>>BrB(Oc1ccccc1)Oc1ccccc1.C1CCOC1,,C1CCOC1,,,,val
US20080105851A1,CCCCCI.c1ccc(CNCc2ccccn2)nc1>>CCCCCN(Cc1ccccn1)Cc1ccccn1,,CN(C)C=O,,[K+].[OH-],,val
US20100120741A1,CC(CO)Nc1nc2cc(Cl)ccc2nc1Cl.CC(CO)Nc1nc2ccc(Cl)cc2nc1Cl>>CC1CN2C(=N1)C(Cl)=Nc1cc(Cl)ccc12.CC1CN2C(=N1)C(Cl)=Nc1ccc(Cl)cc12,,ClC(Cl)Cl,,O=S(Cl)Cl,,val
US05994368,CC(C)C(=O)Cl.Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)C=Cc4ccc(N)c(C)c4)c3Cl)c2n1>>Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)C=Cc4ccc(NC(=O)C(C)C)c(C)c4)c3Cl)c2n1,,ClCCl,,CCN(CC)CC,,val
US04132786,O=[N+]([O-])O.Oc1ccc(Cl)cc1>>O=[N+]([O-])c1cc(Cl)ccc1O,,CC(=O)O,,O,,val
US20110245224A1,CCOC(=O)c1cnn(-c2noc3c(F)c4c(cc23)CC2(C(=O)NC(=O)NC2=O)[C@H]2[C@H](C)O[C@H](C)CN42)c1>>C[C@@H]1CN2c3c(cc4c(-n5cc(CO)cn5)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1,,C1CCOC1,O,CO,[BH4-].[Li+],val
US04113464,C#CCBr.COC(CN)OC>>C#CCNCC(OC)OC,,c1ccccc1,,CCN(CC)CC,,val
US20110152285A1,COc1cccc([N+](=O)[O-])c1CC(=O)[O-]>>COc1cccc([N+](=O)[O-])c1CCO,,C1CCOC1,Cc1ccccc1,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US05185370,CC(=O)CC(C)=O.N#Cc1cccc(C=O)c1>>CC(=O)C(=Cc1cccc(C#N)c1)C(C)=O,,CC(C)O,,C,O=C[O-].[NH4+],val
US20070293507A1,COC(=O)C(O)=CC(=O)c1ccccc1.NN>>COC(=O)c1cc(-c2ccccc2)n[nH]1,,CCO,,O,,val
US04746352,CC(C)OC(=O)c1cc(NC(N)=O)c(F)cc1F.CCOC(=O)C1CCCC1=O>>CCOC(=O)C1=C(NC(=O)Nc2cc(C(=O)OC(C)C)c(F)cc2F)CCC1,,Cc1ccccc1,,,,val
US04610818,CC(C)C[C@H](N)C(=O)NCC(N)=O.O=C(NC1(C(=O)O)CCCCC1)OCc1ccccc1>>CC(C)C[C@H](NC(=O)C1(NC(=O)OCc2ccccc2)CCCCC1)C(=O)NCC(N)=O,,C1CCOC1,CN(C)C=O,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20140162985A1,CC[Si](CC)(CC)O[C@]1(C(F)(F)F)CC[C@@]2(CNC(C)=O)c3cc4cnn(-c5ccc(F)cc5)c4cc3CCC[C@@H]2C1.O=S1(=O)CCCN1C[C@@]12CC[C@](OCc3ccccc3)(C(F)(F)F)C[C@H]1CCCc1cc3c(cnn3-c3ccc(F)cc3)cc12>>CC(=O)NC[C@@]12CC[C@](O)(C(F)(F)F)C[C@H]1CCCc1cc3c(cnn3-c3ccc(F)cc3)cc12.CC(=O)NC[C@]12CC[C@@](O)(C(F)(F)F)C[C@@H]1CCCc1cc3c(cnn3-c3ccc(F)cc3)cc12,,ClCCl,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100261900A1,C#CCCCCC.Cc1ccc(S(=O)(=O)Oc2nn(Cc3ccccc3)c3ccccc23)cc1>>CCCCCC#Cc1nn(Cc2ccccc2)c2ccccc12,,CCCCCCC,ClCCl,,,val
US20110098296A1,Cl.O=[N+]([O-])c1ccc(OCCN2CCCC2)c(Cl)c1>>Cl.Nc1ccc(OCCN2CCCC2)c(Cl)c1,[Pt],CCO,,,,val
US20050137226A1,Cl.Oc1ccc(Sc2ccc(OC3CN4CCC3CC4)cc2)cc1>>Cl.Oc1ccc(Sc2ccc(OC3CN4CCC3CC4)cc2)cc1,,CCOC(C)=O,,C1COCCO1,,val
US20100286115A1,COC(=O)c1cc(OCc2c(-c3ccccc3)noc2C)nn1C.N>>Cc1onc(-c2ccccc2)c1COc1cc(C(N)=O)n(C)n1,,CO,,,,val
US20050127319A1,CCn1ccnc1C.CO.COC(=O)OC>>CC[n+]1ccn(C)c1C.COC(=O)[O-],,CO,,O=C=O,,val
US20140336106A1,CC(C)(C)OC(=O)N[C@@H](CC1CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1.O=C(O)C(F)(F)F>>C[C@]1(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC2CC2)CO1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20090093524A1,COC(=O)c1ccc(-c2ccc(OCc3c(C(C)C)nnn3-c3c(Cl)cccc3Cl)cc2C)cc1>>Cc1cc(OCc2c(C(C)C)nnn2-c2c(Cl)cccc2Cl)ccc1-c1ccc(C(=O)O)cc1,,CO,,[Na+].[OH-],,val
US20100298336A1,CCn1ccc(CSc2nc(C)cc(O)n2)n1.Cl>>CCn1ccc(CSc2nc(C)cc(O)n2)n1.Cl,,CO,,C1COCCO1,,val
US20160075713A1,Clc1ncnc2[nH]ccc12.NC1CCN(CC(F)(F)c2ccc(C(F)(F)F)cc2)CC1>>FC(F)(F)c1ccc(C(F)(F)CN2CCC(Nc3ncnc4[nH]ccc34)CC2)cc1,,CCCCO,,,,val
US20100168094A1,Nc1ccc(C2CCCC2)cc1.O=C1CCC(=O)N1Br>>Nc1ccc(C2CCCC2)cc1Br,,CN(C)C=O,,O,,val
US20090312338A1,COc1ccc2c(c1)c(C#Cc1nc(Br)cnc1N)cn2C>>COc1ccc2c(c1)c(-c1cc3nc(Br)cnc3[nH]1)cn2C,,CN(C)C=O,,[H-].[Na+],,val
US05714633,CC(Br)C#Cc1cccc(Oc2ccc(F)cc2)c1.NO>>CC(C#Cc1cccc(Oc2ccc(F)cc2)c1)NO,,CN1CCCC1=O,O,,,val
US20090118446A1,COCCl.O=C1OCCC1CC1CCCCC1>>COCC1(CC2CCCCC2)CCOC1=O,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US05096919,CC(=O)ON(C(C)=O)C(C)c1ccc(-n2c(C)ccc2C)cc1>>CC(=O)N(O)C(C)c1ccc(-n2c(C)ccc2C)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20090202641A1,CCCCCCCCCCCCCCNCC(=O)NCC(N)=O.CCO>>CCCCCCCCCCCCCCNCC(=O)NCC(N)=O.O,,CCN(CC)CC,,,,val
US20090186891A1,N#Cc1ccc2nc(-c3c(Cl)cccc3Cl)[nH]c2c1.NO>>N=C(NO)c1ccc2nc(-c3c(Cl)cccc3Cl)[nH]c2c1,,CCO,,CCN(CC)CC,Cl,val
US04410540,CC(C)C1NC(=O)NC1C(=O)c1ccccc1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CC(C)C1NC(=O)NC1C(=S)c1ccccc1,,Cc1ccccc1,,,,val
US20020019388A1,CC(C)(C)OC(=O)N1CC[C@H](CO)[C@H](NCc2ccccc2)C1>>CC(C)(C)OC(=O)N1CC[C@H](CO)[C@H](N)C1,[Pd],CCO,,,,val
US20040176367A1,CC(C)=Nn1cnc2cnc3ccccc3c21>>CC(C)Nn1cnc2cnc3ccccc3c21,,CO,,[BH4-].[Na+],,val
US20100113502A1,CC(C)(C)OC(=O)N1CCC2C(C1)c1cc([N+](=O)[O-])ccc1N2S(C)(=O)=O>>CC(C)(C)OC(=O)N1CCC2C(C1)c1cc(N)ccc1N2S(C)(=O)=O,[Pd],C1CCOC1,,,,val
US20100197725A1,CC(Br)c1ccc(F)cc1.O=C1NCCc2c(Br)cccc21>>CC(c1ccc(F)cc1)N1CCc2c(Br)cccc2C1=O,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20090093524A1,CCCCOc1cc(CO)ccc1C(=O)OC>>CCCCOc1cc(C=O)ccc1C(=O)OC,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20120101136A1,CCc1cc(OCCCN(C)C(=O)OC(C)(C)C)ccc1-c1nnc(-c2ccc(OC(C)C)c(C#N)c2)s1>>CCc1cc(OCCCNC)ccc1-c1nnc(-c2ccc(OC(C)C)c(C#N)c2)s1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20120171199A1,Clc1nc(N2CCOCC2)c2ncn(C3CCCCO3)c2n1.O=C1COC1>>OC1(c2nc3c(N4CCOCC4)nc(Cl)nc3n2C2CCCCO2)COC1,,C1CCOC1,,[Li]CCCC,,val
US20110112110A1,C[Si](C)(C)c1ncc([Sn](C)(C)C)s1.Clc1ccc(Br)nc1>>Clc1ccc(-c2cncs2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20120083488A1,CC1(C)c2cc(O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21.CCN(CC)CCCl>>CCN(CC)CCOc1ccc2c(c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O,,CC(=O)N(C)C,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US06642418B1,O=C(Cl)C1CC1.c1c[nH]cn1>>O=C(C1CC1)n1ccnc1,,C1CCOC1,,,,val
US20160221945A1,CI.O=C(OCc1ccccc1)N1CCC(O)CC1.S=C=S>>CSC(=S)OC1CCN(C(=O)OCc2ccccc2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US04962115,COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCNC[C@H]1OC.O=C(c1ccc(F)cc1)N1CC1>>COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCNC(=O)c2ccc(F)cc2)C[C@H]1OC,,CO,,c1ccccc1,,val
US20100137281A1,CCc1cc2c(=O)n(Cc3ccc(OC)cc3OC)c(=O)[nH]c2s1.N#Cc1ccccc1-c1ccc(CBr)cc1>>CCc1cc2c(=O)n(Cc3ccc(OC)cc3OC)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04070481,CC(=O)OC(C)=O.CCCCCCCCCCCCC1=C(O)C(=O)c2c(C)cccc2C1=O>>CCCCCCCCCCCCC1=C(OC(C)=O)C(=O)c2c(C)cccc2C1=O,,c1ccncc1,,,,val
US20130065757A1,COC(=O)c1nc(Cl)cc(NCc2ccc(OC)cc2OC)c1Br>>COC(=O)c1nc(Cl)cc(N)c1Br,,Cl,,,,val
US05294618,BrCCCc1ccccc1.c1ccc2c(c1)CC[C@@H]1CNCC[C@@H]21>>c1ccc(CCCN2CC[C@H]3c4ccccc4CC[C@@H]3C2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110319380A1,CC(C)(C)OC(=O)N1CCCCC1CN.O=C(Cl)CCl>>CC(C)(C)OC(=O)N1CCCCC1CNC(=O)CCl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060258645A1,COc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)C(Cl)(Cl)Cl)n3Cc3ccccc32)cc1.Cc1cc(C(=O)CN)no1>>COc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)NCc4cc(C)on4)n3Cc3ccccc32)cc1,,CC#N,,CCN(CC)CC,CS(C)=O,val
US20100075952A1,CC(=O)OC(C)C(=O)Cl.Nc1cc2c(cc1F)CC(=O)N2>>CC(=O)OC(C)C(=O)Nc1cc2c(cc1F)CC(=O)N2,,C1CCOC1,,C1CCNCC1,,val
US20020188127A1,CC(C)(O)Cn1cnc2c1c1ccccc1n1nnnc21>>CC(C)(O)Cn1cnc2c(N)nc3ccccc3c21,,Clc1ccccc1Cl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150218085A1,Cc1ccc(O)cc1C(CNC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C.O=C(Cl)N(CCCl)CCCl>>Cc1ccc(OC(=O)N(CCCl)CCCl)cc1C(CNC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C,,c1ccncc1,,,,val
US20070066658A1,N#Cc1ccc(Oc2ccc(CCNCc3ccccc3)cc2)cc1.O=C([O-])O.[Li]C>>CC(=O)c1ccc(Oc2ccc(CCNCc3ccccc3)cc2)cc1,,C1CCOC1,CCOCC,O=S(=O)(O)O,,val
US20010051631A1,Cc1cn2c(CN(CCCCNS(=O)(=O)C(F)(F)F)C(=O)OC(C)(C)C)cccc2n1.O=C(Cl)C(Cl)(Cl)Cl>>Cc1nc2cccc(CN(CCCCNS(=O)(=O)C(F)(F)F)C(=O)OC(C)(C)C)n2c1C(=O)C(Cl)(Cl)Cl,CN(C)c1ccncc1,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20130131039A1,CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(-c3nc(Cl)cc4nccn34)cn2)C1.Cl>>Cl.N#CCC1(n2cc(-c3nc(Cl)cc4nccn34)cn2)CNC1,,C1COCCO1,,,,val
US20150080301A1,O=C(CCCCCOc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1>>Nc1ccc(OCCCCCC(=O)Oc2ccc(N)cc2)cc1,[Pd],CCOC(C)=O,,,,val
US06172016B2,CC(CCO)CCc1ccccc1>>CC(CCO)CCC1CCCCC1,[Ni],O,,,,val
US20150158815A1,C[Si](C)(C)C#N.Nc1cncc(Br)c1.O=Cc1ccc(Cl)cc1>>N#CC(Nc1cncc(Br)c1)c1ccc(Cl)cc1,,COCCOC,,,,val
US05866513,CCOC1=CCCCC1=O.COc1cccc(OC)c1OC>>COc1ccc(C2(O)CCCCC2=O)c(OC)c1OC,,C1CCOC1,,CN(C)CCN(C)C,[Li]CCCC,val
US04723991,Cc1nc(C)c(C#N)c(N)n1.O=C=NS(=O)(=O)c1ccccc1Cl>>Cc1nc(C)c(C#N)c(NC(=O)NS(=O)(=O)c2ccccc2Cl)n1,,ClCCl,,C1CN2CCN1CC2,,val
US20110288065A1,CS(=O)(=O)Cl.C[C@H](Nc1nc(Nc2cnccn2)cc(N2CCC(N)C2)n1)c1ccc(F)cc1>>C[C@H](Nc1nc(Nc2cnccn2)cc(N2CCC(NS(C)(=O)=O)C2)n1)c1ccc(F)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,O,val
US20080027096A1,BrCc1cccc(Br)c1.COC(=O)C(O)Cc1cc(Br)c(O)c(Br)c1>>O=C(O)C(O)Cc1cc(Br)c(OCc2cccc(Br)c2)c(Br)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090029994A1,CCOC(=O)C1CCN(c2cnc(N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)Cc3cc(C(F)(F)F)ccc3N(CC)CCOC)nc2)CC1>>CCN(CCOC)c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ncc(N2CCC(C(=O)O)CC2)cn1,,CCO,,CCOC(C)=O,[Na+].[OH-],val
US20150105403A1,Cc1cscc1/C(=C(\c1ccc(/C=C/C(=O)O)cc1)c1ccc2scnc2c1)C1CCC1.NCCO>>Cc1cscc1/C(=C(\c1ccc(/C=C/C(=O)NCCO)cc1)c1ccc2scnc2c1)C1CCC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140235620A1,CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)C2CCNCC2)n1.O=C1CCC1>>CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)C2CCN(C(C)C)CC2)n1,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080021032A1,Cn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)n1.Nc1ccn(Cc2cccc(C(=O)O)c2)n1>>CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(Cc3cccc(C(=O)O)c3)n2)cc1Cl,,ClCCl,,Cc1cccc(C)n1,O=C(Cl)C(=O)Cl,val
US20090181942A1,CCOC(=O)CBr.COc1cccc([C@H]2O[C@H](CCc3nnn[nH]3)c3cccn3-c3ccc(Cl)cc32)c1OC>>CCOC(=O)Cn1nnnc1CC[C@H]1O[C@H](c2cccc(OC)c2OC)c2cc(Cl)ccc2-n2cccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050137184A1,O=C(O)/C=C/C(=O)O.c1cc(-c2ccc(OC3CN4CCC3CC4)cc2)c2cc[nH]c2c1>>O=C(O)/C=C/C(=O)O.c1cc(-c2ccc(OC3CN4CCC3CC4)cc2)c2cc[nH]c2c1,,CCO,CCOC(C)=O,,,val
US20050038043A1,BrBr.CCCc1c(C)ncnc1Cl>>CCCc1c(Cl)ncnc1CBr,,CC(=O)O,,,,val
US20120108583A1,Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(C(F)(F)F)ccc3F)c3c(c2[nH]1)CC(C)(C)O3.O=C(O)CC(O)(CC(=O)O)C(=O)O>>Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(C(F)(F)F)ccc3F)c3c(c2[nH]1)CC(C)(C)O3.O=C(O)CC(O)(CC(=O)O)C(=O)O,,CC(C)=O,,,,val
US20160244815A1,CCC(=O)Oc1cc[c-](CC)c1.[Fe+2].c1cc[cH-]c1>>OCCC[c-]1cccc1.[Fe+2].c1cc[cH-]c1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120230951A1,COC(=O)N[C@H]1CCc2ccn3c2C1C(=O)C[C@H](c1nc2ccc(-c4ccc(-c5ccc(-c6cnc([C@@H]7CC(F)(F)CN7C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]6)cc5)nc4)cc2[nH]1)C3.Clc1cnc2cc(Br)ccc2n1>>COC(=O)N[C@H]1CCc2ccn3c2C1C(=O)C[C@H](c1nc2ccc(-c4cnc5cc(Br)ccc5n4)cc2[nH]1)C3,,O,,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US20120214802A1,COC(=O)[C@H]1CCC(C)=N1>>COC(=O)[C@H]1CC[C@@H](C)N1,[Pd],CCO,,,,val
US20040176435A1,CN.N#Cc1cc2cccc(O[C@H](CCI)c3ccccc3)c2s1.O=C(O)/C=C/C(=O)O>>CNCC[C@@H](Oc1cccc2cc(C#N)sc12)c1ccccc1.O=C(O)/C=C/C(=O)O,,C1CCOC1,CO,,,val
US20080167361A1,CC(C)(C)OC(=O)N1CC[C@@H](c2ccc(S(=O)(=O)c3ccc4[nH]ncc4c3)cc2)C1>>CN1CC[C@@H](c2ccc(S(=O)(=O)c3ccc4[nH]ncc4c3)cc2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110082181A1,Cc1noc(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)c1CC(=O)CCc1ccccc1>>Cc1noc(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)c1CC(O)CCc1ccccc1,,CO,,[BH4-].[Na+],,val
US20100099718A1,O=Cc1ccc([N+](=O)[O-])o1.Oc1ccc(F)cc1>>O=Cc1ccc(Oc2ccc(F)cc2)o1,,O,,CS(C)=O,[H-].[Na+],val
US20130225602A1,Cn1cc(Br)c2ccc(F)nc21.OCc1ccccn1>>Cn1cc(Br)c2ccc(OCc3ccccn3)nc21,,CN(C)C=O,,O,CC(C)(C)[O-].[K+],val
US20160137595A1,C=CC(O)C(F)(F)F.O=[N+]([O-])c1cc(Br)ccc1F>>C=CC(Oc1ccc(Br)cc1[N+](=O)[O-])C(F)(F)F,,C1CCOC1,,Cl,CC(C)(C)[O-].[K+],val
US06054475,COC(=O)c1ccc(OC)c(O)c1.O=C1CCCC1Cl>>COC(=O)c1ccc(OC)c(OC2CCCC2=O)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04672129,BrCc1ccccc1.O=C1c2cccc(O)c2C(=O)c2c(Cl)ccc(Cl)c21>>O=C1c2cccc(OCc3ccccc3)c2C(=O)c2c(Cl)ccc(Cl)c21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150057265A1,CC(C)c1cnc2c(C(=O)O)c(NC(=O)OC(C)(C)C)oc2c1.C[C@@H]1C[C@H](NC(=O)OC(C)(C)C)C[C@H](c2ccncc2N)C1>>CC(C)c1cnc2c(C(=O)Nc3cnccc3[C@H]3C[C@@H](NC(=O)OC(C)(C)C)C[C@@H](C)C3)c(NC(=O)OC(C)(C)C)oc2c1,,ClCCCl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160068513A1,COC(=O)C1CCCN1c1nc2c(c(Nc3ncccn3)n1)CCC2.Nc1nccs1>>O=C(Nc1nccs1)C1CCCN1c1nc2c(c(Nc3ncccn3)n1)CCC2,,C1CCOC1,,CC(C)[Mg]Cl,,val
US04564386,C#CCN.Cc1cc(C)c(S(=O)(=O)Cl)cc1NS(=O)(=O)C(F)(F)F>>C#CCNS(=O)(=O)c1cc(NS(=O)(=O)C(F)(F)F)c(C)cc1C,,C1CCOC1,,,,val
US20080146614A1,COC(=O)c1nn(-c2ccc(Cl)cc2Cl)c(-c2ccc(OC)cc2)c1C.O=C1CCC(=O)N1Br>>COC(=O)c1nn(-c2ccc(Cl)cc2Cl)c(-c2ccc(OC)cc2)c1CBr,,ClCCCl,,,,val
US20110098290A1,COC(=O)c1cc(C(C)C)c(O)cc1O.COS(=O)(=O)OC>>COC(=O)c1cc(C(C)C)c(OC)cc1O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04146715,CCO.Nc1nc2c(ncn2COCCN2C(=O)c3ccccc3C2=O)c(=O)[nH]1.O>>CC(=O)O.NCCOCn1cnc2c(=O)[nH]c(N)nc21.O,,CCO,,NN,,val
US20160272592A1,COCc1ccc(C2CCC2)c(CNC(=O)Nc2c(C)c(OC[C@H]3COC(C)(C)O3)nn2-c2ccccc2)c1>>COCc1ccc(C2CCC2)c(CNC(=O)Nc2c(C)c(OC[C@H](O)CO)nn2-c2ccccc2)c1,,C1CCOC1,,Cl,,val
US04435408,O=C(N1CCCC(c2cccc3[nH]ccc23)C1)C(F)(F)F.O=C1CCC(=O)N1Cl>>O=C(N1CCCC(c2cccc3[nH]cc(Cl)c23)C1)C(F)(F)F,,O,,C1COCCO1,,val
US20110319454A1,CC1(C)C2CCC1C1C(=O)OC(=O)C12.Nc1ccc(Br)cc1>>CC1(C)[C@H]2CC[C@@H]1[C@H](C(=O)O)[C@@H]2C(=O)Nc1ccc(Br)cc1,,ClC(Cl)Cl,,,,val
US20160039838A1,C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(N)cc23)c1.O=C(Cl)/C=C/CN1C[C@H]2OCCO[C@H]2C1>>C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(NC(=O)/C=C/CN4C[C@H]5OCCO[C@H]5C4)cc23)c1,,C1CCOC1,ClCCl,O,O=C([O-])[O-].[Na+].[Na+],val
US20140175384A1,COc1ccc(Br)c(-c2ccccc2)c1.OB(O)c1ccc2ccc3cccc4ccc1c2c34>>COc1ccc(-c2ccc3ccc4cccc5ccc2c3c45)c(-c2ccccc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US06399629B1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@@H]1C[C@@H](N)CN1C(=O)CN(C)C(=O)OC(C)(C)C>>COC(=O)[C@@H]1C[C@@H](NC(=O)OC(C)(C)C)CN1C(=O)CN(C)C(=O)OC(C)(C)C,,C1CCOC1,,,,val
US04130652,CC[O+](CC)CC.F[B-](F)(F)F.O=C(C=C1NCCN1)c1ccccc1>>CCOC(=CC1=NCCN1)c1ccccc1.F[B-](F)(F)F,,ClCCl,,,,val
US20120289549A1,N[C@@H]1C[C@H]2CN(c3ccc(OC(F)(F)F)cc3)C(=O)N2C1.O=C(Cl)c1ccccc1Cl>>O=C(N[C@@H]1C[C@H]2CN(c3ccc(OC(F)(F)F)cc3)C(=O)N2C1)c1ccccc1Cl,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20080167314A1,Cc1cccc(-c2nc3cccnn3c2-c2ccnc(N)c2)c1.O=C(Cl)OCC(Cl)(Cl)Cl>>Cc1cccc(-c2nc3cccnn3c2-c2ccnc(NC(=O)OCC(Cl)(Cl)Cl)c2)c1,,c1ccncc1,,O=C([O-])O.[Na+],,val
US20150045378A1,CCOC(=O)CC(c1cc(NCc2ccc(-c3cc(OC)ccc3F)c(OCC(C)C)n2)ncn1)C1CC1>>COc1ccc(F)c(-c2ccc(CNc3cc(C(CC(=O)O)C4CC4)ncn3)nc2OCC(C)C)c1,,CO,,Cl,[Na+].[OH-],val
US04344946,CCN(CC)N(C(C)=O)c1nc2cc3nc(N)sc3cc2s1.O=C(Cl)CCl>>CCN(CC)N(C(C)=O)c1nc2cc3nc(NC(=O)CCl)sc3cc2s1,,CN(C)C=O,,O,c1ccncc1,val
US20140045872A1,C[N+](=O)[O-].O=Cc1ccc(Br)s1>>O=[N+]([O-])C=Cc1ccc(Br)s1,,CCO,,[Na+].[OH-],,val
US20120220566A1,CC(C)(C)OC(=O)N1CCC(n2ccc(=O)[nH]c2=O)C1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCC(n2cc(Br)c(=O)[nH]c2=O)C1,,CN(C)C=O,,,,val
US05990142,CCOC(=O)c1cc(=O)c2cc(Br)cc([N+](=O)[O-])c2o1>>CCOC(=O)c1cc(=O)c2cccc([N+](=O)[O-])c2o1,[Pd],CN(C)C=O,,O=CO,,val
US20150315126A1,CCOC(=O)C1([N+](=O)[O-])CC1c1ccccc1>>CCOC(=O)C1(N)CC1c1ccccc1,[Zn],CC(C)O,,Cl,,val
US20120208817A1,CCOc1cc(C=O)cc2oc(=O)[nH]c12.NC(N)=O.O=C(Cc1ccccc1)c1ccccc1>>CCOc1cc(C2NC(=O)NC(c3ccccc3)=C2c2ccccc2)cc2oc(=O)[nH]c12,,CCO,,Cl,,val
US04659706,Br.CC(=O)Br.CS(=O)(=O)c1cc2c(cc1O)CCNCC2>>Br.CC(=O)Oc1cc2c(cc1S(C)(=O)=O)CCNCC2,,O=C(O)C(F)(F)F,,,,val
US20050085465A1,CC(=O)N1CCN(CCO)CC1.COc1cc2ncnc(Oc3ccc4[nH]ccc4c3F)c2cc1O>>COc1cc2ncnc(Oc3ccc4[nH]ccc4c3F)c2cc1OCCN1CCN(C(C)=O)CC1,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120232056A1,COC(=O)c1ccc2nc(-c3ccc(F)cc3C)c(N3CCC[C@@H]3C)nc2c1>>Cc1cc(F)ccc1-c1nc2ccc(C(=O)O)cc2nc1N1CCC[C@@H]1C,,CO,O,[Na+].[OH-],,val
US20110212102A1,Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCCN(C(=O)OC(C)(C)C)C3)c12.O=C1CCC(=O)N1O>>Cc1c(C(=O)ON2C(=O)CCC2=O)sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCCN(C(=O)OC(C)(C)C)C3)c12,,CN(C)C=O,,ClCCCl,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(C(=O)O)c(OC(C)=O)c2)=C(C)C1=O.Nc1cccnc1>>COC1=C(OC)C(=O)C(Cc2ccc(C(=O)Nc3cccnc3)c(OC(C)=O)c2)=C(C)C1=O,,ClC(Cl)Cl,ClCCl,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US20040063705A1,CC(=O)N1CC(C)(C)c2ccc(Nc3nccc(Nc4cnc5ccccc5c4)n3)cc21>>CC1(C)CNc2cc(Nc3nccc(Nc4cnc5ccccc5c4)n3)ccc21,Cl,CCO,,CCOC(C)=O,O=C([O-])O.[Na+],val
US20160060255A1,CCCC[Sn](CCCC)(CCCC)c1cncs1.Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(Cl)n1>>Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cncs2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,C1COCCO1,O=C([O-])O.[Na+],val
US20080004309A1,CCOC(=O)C(Cl)C(C)=O.CN(C(N)=S)c1ccccc1>>CCOC(=O)c1sc(N(C)c2ccccc2)nc1C,,CCO,,,,val
US20090054465A1,CNOC.O=C(O)Cc1ccccc1Cl>>CON(C)C(=O)Cc1ccccc1Cl,,ClCCl,,Cl,,val
US20070244125A1,CC(C)N1CCN(C(=O)c2ccc3[nH]c(C(=O)N4CCS(=O)(=O)CC4)cc3c2)CC1.N#CCBr>>CC(C)N1CCN(C(=O)c2ccc3c(c2)cc(C(=O)N2CCS(=O)(=O)CC2)n3CC#N)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20090093524A1,CC(C)c1nnn(-c2c(Cl)cccc2Cl)c1CO.O=Cc1ccc(F)cc1Cl>>CC(C)c1nnn(-c2c(Cl)cccc2Cl)c1COc1ccc(C=O)c(Cl)c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20030195221A1,CC(C)(Nc1nc(NN)c(-c2ccc(F)cc2)c(-c2ccncc2)n1)c1ccccc1.COC(OC)OC>>CC(C)(Nc1nc(-c2ccncc2)c(-c2ccc(F)cc2)c2nncn12)c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05206375,CN(C)C=Nc1sc(C=O)c(Cl)c1C#N>>N#Cc1c(N)sc(C=O)c1Cl,,O,,O=CO,,val
US20060035844A1,CC(=O)OC[C@H]1O[C@H](OC(=N)C(Cl)(Cl)Cl)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.COC(=O)Oc1cc(C)c(Cc2ccc([N+](=O)[O-])cc2)c(O)c1>>COC(=O)Oc1cc(C)c(Cc2ccc([N+](=O)[O-])cc2)c(O[C@@H]2O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)c1,,ClCCl,,O,,val
US20130005707A1,FC(F)(F)c1ccc(Nc2nc3cccc(Br)n3n2)cc1.O[C@H]1CCCNC1>>O[C@H]1CCCN(c2cccc3nc(Nc4ccc(C(F)(F)F)cc4)nn23)C1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,Cl,val
US20160145268A1,Cc1c(Br)cnc(O)c1[N+](=O)[O-]>>Cc1c(Br)cnc(O)c1N,,CCO,,Cl[Sn]Cl,,val
US20160272617A1,CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](C(=O)N[C@@H](Cc2ccc(-c3ccc(C(=O)O)c(F)c3)cc2)C(=O)Nc2ccc(-c3n[nH]c(C(F)(F)C(F)(F)C(=O)O)n3)cc2)CC1.N[C@H]1CC[C@H](O)CC1>>CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](C(=O)N[C@@H](Cc2ccc(-c3ccc(C(=O)N[C@@H]4CC[C@@H](O)CC4)c(F)c3)cc2)C(=O)Nc2ccc(-c3n[nH]c(C(F)(F)C(F)(F)C(=O)O)n3)cc2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060074056A1,CC(C)(C)OC(=O)N1CC(O[Si](C)(C)C(C)(C)C)C1>>CC(C)(C)[Si](C)(C)OC1CNC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05843942,BrC(Br)(Br)Br.CC(O)c1cc(Br)ccc1OCc1ccccc1>>CC(Br)c1cc(Br)ccc1OCc1ccccc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120202785A1,C[C@@H](CO)NC(=O)OC(C)(C)C.O=[N+]([O-])c1ccc(F)c(O)c1F>>C[C@@H](COc1c(F)ccc([N+](=O)[O-])c1F)NC(=O)OC(C)(C)C,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140315889A1,CN1CCCNCC1.COC(=O)c1ccc(Cn2c3c(c4cc(F)ccc42)C(=O)N(CCO)CC3)cc1>>COC(=O)c1ccc(Cn2c3c(c4cc(F)ccc42)C(=O)N(CCN2CCCN(C)CC2)CC3)cc1,,CC#N,,CCN(C(C)C)C(C)C,CS(=O)(=O)Cl,val
US20090099231A1,CC(C)(C)OC(=O)N1CCc2cc(N3CC[C@H](NS(=O)(=O)c4cc5ccc(Cl)cc5n4C(=O)OC(C)(C)C)C3=O)ccc2C1>>O=C1[C@@H](NS(=O)(=O)c2cc3ccc(Cl)cc3[nH]2)CCN1c1ccc2c(c1)CCNC2.O=CO,,CO,,Cl,,val
US05646173,COc1ccc2c(c1)C(=O)C(CC=O)CC2.C[C@H](O)CN>>COc1ccc2c(c1)-c1c(ccn1CC(C)O)CC2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04521430,COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2O)cc1.O=C(Cl)c1cc(Cl)ccc1[N+](=O)[O-]>>COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(=O)c2cc(Cl)ccc2[N+](=O)[O-])cc1,,ClCCl,,CCN(CC)CC,,val
US20040209897A1,BrC(Br)(Br)Br.O=Cc1c(F)cc(N2CCOCC2)cc1F>>Fc1cc(N2CCOCC2)cc(F)c1C=C(Br)Br,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150210720A1,COCC1(C)CC(=O)c2c(C(=O)Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cc3OC)coc2C1>>COCC1(C)CC(=O)c2c(C(=O)Nc3ccc(N4CCNCC4)cc3OC)coc2C1,,O=C(O)C(F)(F)F,,,,val
US20070244154A1,CNC(=O)C1Cc2c(nc(C)n2C)C2=C1C(=O)[C@H](OC(C)=O)[C@@H](c1ccccc1)N2>>CNC(=O)c1cc2c(nc(C)n2C)c2c1C(=O)[C@H](OC(C)=O)[C@@H](c1ccccc1)N2,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20060063762A1,CC(C)(C)OC(=O)N(CCn1ccc2c(O[Si](C)(C)C(C)(C)C)cccc21)C[C@H](O)c1cccnc1>>CC(C)(C)OC(=O)N(CCn1ccc2c(O)cccc21)C[C@H](O)c1cccnc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20070117839A1,C=CCN.O=[N+]([O-])/C=C/c1cc(F)c(F)c(F)c1>>C=CCNC(CN)c1cc(F)c(F)c(F)c1,,C1CCOC1,,,,val
US20100331318A1,CCOC(=O)CCNC(=O)OC(C)(C)C.COc1ccc2ccc(F)c(CBr)c2n1>>CCOC(=O)C(CNC(=O)OC(C)(C)C)Cc1c(F)ccc2ccc(OC)nc12,,C1CCOC1,CCOC(C)=O,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20120277237A1,CC#C[Si](C)(C)C.Fc1ccc(C#CCBr)cc1>>C[Si](C)(C)C#CCCC#Cc1ccc(F)cc1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US05102667,COc1ccccc1CC(=O)O.O=C1CCC(c2ccccc2)(c2ccccc2)C2CNCC12>>COc1ccccc1CC(=O)N1C[C@@H]2C(=O)CCC(c3ccccc3)(c3ccccc3)[C@@H]2C1,,ClCCl,,CCN(CC)CC,Cl,val
US04559349,Cl.N#CCN1CCC(C(=O)c2ccc(F)cc2)CC1>>Cl.NCCN1CCC(C(=O)c2ccc(F)cc2)CC1,O=[Pt],CC(=O)O,,[H][H],,val
US20100113462A1,CCOC(=O)C1(NC(=O)c2cccc3[nH]ccc23)Cc2ccccc2C1>>O=C(NC1(C(=O)O)Cc2ccccc2C1)c1cccc2[nH]ccc12,,CCO,,O,[K+].[OH-],val
US05707987,CS(=O)(=O)OC[C@@H]1C[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)CN1C(=O)OCc1ccc([N+](=O)[O-])cc1.Sc1ccccc1>>O=C(OCc1ccc([N+](=O)[O-])cc1)N1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CSc1ccccc1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US20080015203A1,COC(=O)c1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(O[C@@H](C)CO[Si](C)(C)C(C)(C)C)c1>>C[C@@H](CO[Si](C)(C)C(C)(C)C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)O)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20040242606A1,BrBr.COCC(=O)Nc1ccc2c(c1)CCC2>>COCC(=O)Nc1cc2c(cc1Br)CCC2,,O,,CC(=O)O,,val
US20030055265A1,CCOC(=O)C(Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)c2c1CCC2)OCC>>CCOC(Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)c2c1CCC2)C(=O)O,,C1COCCO1,O,Cl,[Li+].[OH-],val
US20100152160A1,CN(C)c1cc2c(cc1Cl)N(C(=O)OC(C)(C)C)CC(C(=O)N1CCC(C#N)(Cc3ccc(F)cc3)CC1)O2>>CN(C)c1cc2c(cc1Cl)NCC(C(=O)N1CCC(C#N)(Cc3ccc(F)cc3)CC1)O2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050009820A1,CCC1CCc2c(sc3cc(OC)ccc3c2=O)C1>>CCC1CCc2c(sc3cc(O)ccc3c2=O)C1,,CC(=O)O,,Br,,val
US20020049236A1,C=CCOC(=O)NC(Cc1cc(C2CCCN2C(=O)OC(C)(C)C)no1)C(=O)OCC.Cl>>C=CCOC(=O)NC(Cc1cc(C2CCCN2)no1)C(=O)OCC.Cl,,C1COCCO1,,,,val
US20150252059A1,C#CCOc1cnc(C(=O)OC)c(C)n1>>C#CCOc1cnc(C(=O)O)c(C)n1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20140179667A1,CNC(=O)c1ccc2c(c1C)C(=O)N(Cc1c(C)cc(C)nc1OCc1ccccc1)CCO2.CO>>Cc1cc(C)c(CN2CCOc3ccc(C(=O)N(C)C)c(C)c3C2=O)c(=O)[nH]1,[Pd],,,,,val
US20090247547A1,COC(=O)/C=C/c1ccc([C@@H]2CCCN2C(=O)OC(C)(C)C)cc1.Cl>>COC(=O)/C=C/c1ccc([C@@H]2CCCN2)cc1.Cl,,C1COCCO1,,CCOCC,,val
US20100168094A1,CCOC(=O)CCc1ccc(O)c(C2CCCC2)c1.COC(=O)Cl>>CCOC(=O)CCc1ccc(OC(=O)OC)c(C2CCCC2)c1,,ClCCl,,CCN(CC)CC,,val
US20120172351A1,CCC(=O)Cl.COC(=O)C[C@@H]1COc2cc(N(C(=O)C(F)(F)F)[C@@H]3COc4c(Nc5c(N)ccc(F)c5F)cccc43)ccc21>>CCc1nc2ccc(F)c(F)c2n1-c1cccc2c1OC[C@H]2N(C(=O)C(F)(F)F)c1ccc2c(c1)OC[C@H]2CC(=O)OC,,CC(=O)N(C)C,,O=C([O-])O.[Na+],,val
US05650428,CCOC(=O)Cc1ccc(NC(=O)C(COC2CCCCO2)NC(=O)OCc2ccccc2)cc1.Cc1ccc(S(=O)(=O)Cl)cc1>>CCOC(=O)Cc1ccc(NC(=O)C(COC2CCCCO2)NS(=O)(=O)c2ccc(C)cc2)cc1,[Pd],,,,,val
US20150210647A1,CC1CCC(Oc2ccc3ccc(CO)cc3c2C(F)(F)F)CC1.CS(=O)(=O)Cl>>C[C@@H]1CC[C@H](Oc2ccc3ccc(COS(C)(=O)=O)cc3c2C(F)(F)F)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130310395A1,CC(F)(F)Oc1ccc([N+](=O)[O-])cc1>>CC(F)(F)Oc1ccc(N)cc1,[Ni],CCO,,,,val
US20130184272A1,CCCOc1sc(C(=O)O)c2c1-c1c(cnn1C)CC2.CCN=C=NCCCN(C)C>>CCCOc1sc(C(N)=O)c2c1-c1c(cnn1C)CC2,,CN(C)C=O,,O,,val
US20060079503A1,CCCOC(=O)CC#N.CCN=C=S>>CCCOC(=O)C(C#N)C(=S)NCC,,CCN(CC)CC,,,,val
US20020103230A1,CCOC(=O)Cc1nc2cc(N3CCC(N(C)C)C3)ccc2[nH]1.N#Cc1ncccc1N>>CN(C)C1CCN(c2ccc3[nH]c(-c4c(N)c5ncccc5[nH]c4=O)nc3c2)C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20040067966A1,CCCn1c(=O)c2[nH]c(C34CCCC(C=CC(=O)O)(CCC3)C4)nc2n(CCC)c1=O>>CCCn1c(=O)c2[nH]c(C34CCCC(CCC(=O)O)(CCC3)C4)nc2n(CCC)c1=O,[Pd],C1CCOC1,CO,,,val
US20100273795A1,Cc1cc(C)cc(Oc2ccc(C#N)cc2[N+](=O)[O-])c1>>Cc1cc(C)cc(Oc2ccc(C#N)cc2N)c1,,C1CCOC1,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US05273974,CC(=O)N1CCC(CCC(=O)c2ccc3c(c2)CCO3)CC1>>O=C(CCC1CCNCC1)c1ccc2c(c1)CCO2,,Cl,,[Na+].[OH-],,val
US05578620,CC(C)(C)[Si](C)(C)Cl.C[C@@H](CO)NC(=O)OCc1ccccc1>>C[C@H](CO[Si](C)(C)C(C)(C)C)NC(=O)OCc1ccccc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20150038574A1,CC1(C)CCC(C)(C)C(C=O)C1.Nc1cccc(F)c1>>CC1(C)CCC(C)(C)C(CNc2cccc(F)c2)C1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20120142668A1,COc1ccc(NC(=O)/C=C/[C@H](CC(C)C)NC(=O)[C@H](C)N(C(=O)[O-])C(C)(C)C)cc1.O=C(O)C(F)(F)F>>COc1ccc(NC(=O)/C=C/[C@H](CC(C)C)NC(=O)[C@H](C)N)cc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04929613,CC(=O)N1CC=C(c2cc(F)c(C(=O)O)cc2F)CC1>>CC(=O)N1CCC(c2cc(F)c(C(=O)O)cc2F)CC1,[Pd],CC(=O)O,,,,val
US05849744,CC(=O)Cl.COC1CCC(CN)(OC)O1>>COC1CCC(CNC(C)=O)(OC)O1,,C1CCOC1,,CCN(CC)CC,,val
US20110097287A1,CCCCCCCCCCCCCCCCCCCCCC(=O)O.OCCOCCO>>CCCCCCCCCCCCCCCCCCCCCC(=O)OCCOCCO,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US04830660,CCOC(=O)c1ncn(-c2nncs2)c1S(N)(=O)=O.COc1cc(OC)nc(N(C(=O)[O-])c2ccccc2)n1>>CCOC(=O)c1ncn(-c2nncs2)c1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC)n1,,CC#N,,,,val
US20090143358A1,CS(=O)(=O)Cl.O[C@@H]1COC[C@@H]1c1ccc(F)cc1>>CS(=O)(=O)O[C@H]1COC[C@@H]1c1ccc(F)cc1,,ClCCl,O,CCN(CC)CC,,val
US20100160369A1,Cc1ccc(S(=O)(=O)OCC2COC(=O)N2)cc1.Oc1cc(Cl)c(-c2nnc(-c3cn4cc(C(F)(F)F)cc(Cl)c4n3)s2)cc1Cl>>O=C1N[C@H](COc2cc(Cl)c(-c3nnc(-c4cn5cc(C(F)(F)F)cc(Cl)c5n4)s3)cc2Cl)CO1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06013663,CCCCN.CO.O=C1c2ccccc2C(=O)N1CCCCCC1CCSS1>>CCOC(=O)NCCCCCC1CCSS1,,Cc1ccccc1,,,,val
US20160137595A1,C=CC(c1ccccc1)c1cc(Br)cc([N+](=O)[O-])c1OCCC>>C=CC(c1ccccc1)c1cc(Br)cc(N)c1OCCC,[Zn],CCO,ClCCl,O,[Cl-].[NH4+],val
US20040116328A1,CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc(CO)c1C(N)=S.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1>>CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c1C(N)=S,,CCOC(C)=O,,CN(C)C=O,c1c[nH]cn1,val
US05824691,COC(=O)c1cccc(C(=O)C=CN(C)C)c1.N=CN>>COC(=O)c1cccc(-c2ccncn2)c1,,CO,,CC(=O)O,C[O-].[Na+],val
US20110275611A1,CNc1nc(Cl)cc(Cl)n1.C[C@@H]1COCCN1>>CNc1nc(Cl)cc(N2CCOC[C@H]2C)n1,,CCO,,CCN(C(C)C)C(C)C,,val
US20040209905A1,BrCCCBr.CCCNC(=O)Nc1cc(C)c(Oc2ccnc3cc(O)c(OC)cc23)cc1C>>CCCNC(=O)Nc1cc(C)c(Oc2ccnc3cc(OCCCBr)c(OC)cc23)cc1C,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05385922,C1CCOC1.N[C@@H](CS)C(=O)O.O=CCCc1ccccc1>>CC(=O)N1C(CCc2ccccc2)SCC1C(=O)O,,O,,,,val
US20160016936A1,CC(C)Oc1c(N)ncnc1Cl.Cc1cc(-c2cn(CCN3CCC3)c([C@H]3CCNC[C@H]3F)n2)ccc1F>>Cc1cc(-c2cn(CCN3CCC3)c([C@H]3CCN(c4ncnc(N)c4OC(C)C)C[C@H]3F)n2)ccc1F,,CN1CCCC1=O,,C1CCC2=NCCCN2CC1,,val
US20120232051A1,CS(=O)(=O)CCNc1cnccc1-c1ccccc1Cl.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CS(=O)(=O)CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1-c1ccccc1Cl,,CCCCCCC,CCOC(C)=O,,,val
US20070142372A1,BrCC1CCCO1.Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2[nH]ncc2c1>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(cnn2CC2CCCO2)c1,,CN(C)C=O,,[H-].[Na+],,val
US06713473B1,CC(C)c1cccc2c1[nH]c1cc(F)c([N+](=O)[O-])cc12>>CC(C)c1cccc2c1[nH]c1cc(F)c(N)cc12,[Fe],CC(C)O,O,,,val
US20060014945A1,COC(=O)c1ccc(CN(C2CC(C(F)(F)F)CCNC2=O)S(=O)(=O)c2ccc(Cl)cc2)c(F)c1>>O=C(O)c1ccc(CN(C2CC(C(F)(F)F)CCNC2=O)S(=O)(=O)c2ccc(Cl)cc2)c(F)c1,,C1CCOC1,,[Na+].[OH-],,val
US05922733,COc1cc2scc(C(=O)O)c2cc1Br.Nc1cccnc1>>COc1cc2scc(C(=O)Nc3cccnc3)c2cc1Br,,O=S(Cl)Cl,,,,val
US20090042890A1,CCOC(=O)c1nc(N[C@@H]2CC[C@@H](O)CC2)nc2c1[nH]c(=O)n2-c1ccccc1OC.CCOC(=O)c1nc(N[C@H]2CC[C@H](O)CC2)nc(Nc2ccccc2OC)c1N>>COc1ccccc1-n1c(=O)[nH]c2c(C(N)=O)nc(N[C@@H]3CC[C@@H](O)CC3)nc21,,ClCCl,,,,val
US20030207885A1,CCCc1c(C(=O)[O-])nc2ccccn12>>CCCc1c(CO)nc2ccccn12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06057451,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCN(CCCC)C(=O)NCCc1ccc(-c2csc(N)n2)cc1>>CCCCN(CCCC)C(=O)NCCc1ccc(-c2csc(NC(=O)OC(C)(C)C)n2)cc1,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20150210688A1,Nc1ccc(Br)cc1.O=CNNC=O>>Brc1ccc(-n2cnnc2)cc1,,c1ccncc1,,CCN(CC)CC,C[Si](C)(C)Cl,val
US05519029,CNN.O=C1c2ccncc2C(=O)c2c(Cl)ccc(F)c21>>Cn1nc2c3c(c(Cl)ccc31)C(=O)c1cnccc1-2,,c1ccncc1,,,,val
US20130281490A1,CC(C)(CCc1ccccc1)C(=O)O>>CC(C)(CO)CCc1ccccc1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050222118A1,CC(C)(C)OC(=O)N[C@H](CO)CC(=O)OCc1ccccc1.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N[C@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)CC(=O)OCc1ccccc1,,CN(C)C=O,O,c1c[nH]cn1,,val
US20070066624A1,NCc1ccc(CN2CCC(N3C(=O)N(C4CCOCC4)C[C@H]3c3ccccc3)CC2)cc1.O=C=NCc1ccccc1>>O=C(NCc1ccccc1)NCc1ccc(CN2CCC(N3C(=O)N(C4CCOCC4)C[C@H]3c3ccccc3)CC2)cc1,,CC(C)O,,,,val
US20150038488A1,COc1ccc(-c2cc3ncn(C(F)F)c3c(=O)[nH]2)cc1OC.COc1ccc([C@@H](C)N2C[C@H]([C@H](C)O)CC2=O)cc1>>COc1ccc([C@@H](C)N2C[C@H]([C@@H](C)Oc3nc(-c4ccc(OC)c(OC)c4)cc4ncn(C(F)F)c34)CC2=O)cc1,,C1CCOC1,ClCCl,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040157886A1,Cc1ccc(CC2CCN(C(=O)C(=O)O)CC2)cc1.Nc1ccc2[nH]c(=O)[nH]c2c1>>Cc1ccc(CC2CCN(C(=O)C(=O)Nc3ccc4[nH]c(=O)[nH]c4c3)CC2)cc1,,CCOCC,,,,val
US05025012,BrC1CCCC1.COC(=O)c1ccc(N2CCNCC2)nc1>>COC(=O)c1ccc(N2CCN(C3CCCC3)CC2)nc1,,CN(C)C=O,O,[I-].[Na+],,val
US20100130474A1,CC(CC(=O)O)CN1CCCC1.COc1cncc(-c2cc(N)n(C(=O)OC(C)(C)C)n2)c1>>COc1cncc(-c2cc(NC(=O)CC(C)CN3CCCC3)[nH]n2)c1,,CC#N,CN(C)C=O,Cl,O=C(Cl)C(=O)Cl,val
US05639766,CCOC(=O)[C@@H]1CCCN(CCBr)C1.ON=C1CC(c2ccccc2)c2ccccc21>>CCOC(=O)[C@@H]1CCCN(CCON=C2CC(c3ccccc3)c3ccccc32)C1,,CC(C)=O,,Br,O=C([O-])[O-].[K+].[K+],val
US20050171109A1,COc1ccc(F)cc1C(C)(C)CC(O)(C=Nc1cc(F)cc2c1CNC2=O)C(F)(F)F>>CC1(C)CC(O)(C(F)(F)F)C(Nc2cc(F)cc3c2CNC3=O)c2c(F)ccc(O)c21,,ClCCl,,BrB(Br)Br,CO,val
US20060122064A1,CCOC(=O)CCc1ccc(O)c(OC)c1.CS(=O)(=O)OCCF>>CCOC(=O)CCc1ccc(OCCF)c(OC)c1,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20040116518A1,CCOC(=O)C1CCNCC1.COc1ccccc1Sc1ccc(/C=C/C(=O)O)c(C(F)(F)F)c1Cl>>CCOC(=O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccccc3OC)c(Cl)c2C(F)(F)F)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130079335A1,CCN.CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(-c3ccc(C=O)cc3)ccc2-n2c(C)nnc21>>CCNCc1ccc(-c2ccc3c(c2)C(c2ccc(Cl)cc2)=N[C@@H](CC(=O)NCC)c2nnc(C)n2-3)cc1,,CC(=O)O,ClCCl,Cl,O=C([O-])O.[Na+],val
US20040034034A1,COc1ccc(Cl)cc1S(N)(=O)=O>>NS(=O)(=O)c1cc(Cl)ccc1O,,ClCCl,,BrB(Br)Br,,val
US20090317360A1,Nc1ccc(N2CCOCC2)cc1.Nc1nc(-c2ccc(C(=O)O)cc2)cs1>>Nc1nc(-c2ccc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc2)cs1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120214993A1,Brc1cc(Br)cc(-c2nc(-c3ccccc3)nc(-c3ccccc3)n2)c1.CC1(C)C=CC2=c3c(ccc4ccc(B(O)O)cc34)=CC2=C1.OB(O)c1ccc(-c2ccccn2)cc1>>CC1(C)C=CC2=c3c(ccc4ccc(-c5cc(-c6ccc(-c7ccccn7)cc6)cc(-c6nc(-c7ccccc7)nc(-c7ccccc7)n6)c5)cc34)=CC2=C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US20090318475A1,CC(=O)CN(C)Cc1ccccc1>>CC(O)CN(C)Cc1ccccc1,,CO,,[BH4-].[Na+],,val
US20120252805A1,CCOC(=O)CC(C)=O.COc1cccc(-c2csc(N)c2C#N)c1>>CCOC(=O)c1c(C)nc2scc(-c3cccc(OC)c3)c2c1N,,Cc1ccccc1,,Cl[Sn](Cl)(Cl)Cl,,val
US20140073620A1,C=O.NC(=O)C1(c2ccccc2CCc2nc(Nc3ccc(C4CCNCC4)nc3)ncc2C(F)(F)F)CC1>>CN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4C4(C(N)=O)CC4)n3)cn2)CC1,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20040102479A1,CSC(=NC#N)SC.NCCCC(F)(F)C(F)(F)F>>CSC(=NCCCC(F)(F)C(F)(F)F)NC#N,,CCO,,,,val
US20090163489A1,CC(=O)Nc1cn2nc(-c3cccc(NS(=O)(=O)c4ccc(C)cc4)c3)ccc2n1.CI>>CC(=O)Nc1cn2nc(-c3cccc(N(C)S(=O)(=O)c4ccc(C)cc4)c3)ccc2n1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20030176398A1,CC(C)C(Cl)OC(=O)Cl.NCC1(CC(=O)O)CCCCC1>>CC(C)C(Cl)OC(=O)NCC1(CC(=O)O)CCCCC1,,ClCCl,,CCN(CC)CC,C[Si](C)(C)Cl,val
US05807873,CCOC(=O)/C(CCO)=C(\c1ccc(Cl)cc1)c1ccc(S(C)(=O)=O)cc1>>CS(=O)(=O)c1ccc(/C(=C2\CCOC2=O)c2ccc(Cl)cc2)cc1,,Cc1ccccc1,,,,val
US20040122108A1,COc1c(C(=O)CNC(C)(C)Cc2c(C)cc(C)cc2C)ccc2c1OC(c1ccccc1)(c1ccccc1)O2>>COc1c(C(=O)CNC(C)(C)Cc2c(C)cc(C)cc2C)ccc(O)c1O,,Cl,,,,val
US20130064770A1,BrCc1nc2ccccc2s1.FCCOc1ccccc1N1CCNCC1>>FCCOc1ccccc1N1CCN(Cc2nc3ccccc3s2)CC1,CCN(CC)CC,CC#N,,Cl,Cl,val
US20040018986A1,CCOC(=O)c1[nH]c2ccccc2c1C(C)=O.CCOC(=O)c1cc2cc(C(C)=O)ccc2[nH]1>>CC(=O)c1c(C(=O)O)[nH]c2ccccc12.CC(=O)c1ccc2[nH]c(C(=O)O)cc2c1,,CCO,,Cl,[K+].[OH-],val
US20150031651A1,CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/Cc1c(C)c(O)c2ccccc2c1OC(=O)c1ccccc1.CCOP(=O)(Cl)OCC>>CCOP(=O)(OCC)Oc1c(C)c(C/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CCC=C(C)C)c(OC(=O)c2ccccc2)c2ccccc12,,ClCCl,,CCN(CC)CC,,val
US20150119385A1,CC(C)(C)Nc1cc(N)ncc1C#N.COC(OC)c1nc2c(cc1CN1CCN(C)CC1=O)CCCN2.O=C(n1cncn1)n1cncn1>>COC(OC)c1nc2c(cc1CN1CCN(C)CC1=O)CCCN2C(=O)Nc1cc(NC(C)(C)C)c(C#N)cn1,,CN(C)C=O,,,,val
US20060046999A1,CCOc1[nH]c(=O)ccc1C(=O)c1ccccc1.NCC1CCCCC1>>O=C(c1ccccc1)c1ccc(=O)[nH]c1NCC1CCCCC1,,Cc1ccccc1,,,,val
US20080275043A1,C[C@@H]1CC2(CC[C@@H]1N1CCC(Cc3ccc(Cl)cc3Cl)C1=O)OCCO2>>C[C@H]1CC(=O)CC[C@H]1N1CCC(Cc2ccc(Cl)cc2Cl)C1=O,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150376219A1,CCI.Cc1cn(-c2ncnc3nc[nH]c23)cc(C)c1=O>>CCn1cnc2c(-n3cc(C)c(=O)c(C)c3)ncnc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030055002A1,CSC(CC(=O)NCCc1ccccc1)C1CCCN1C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CSC(CC(=O)NCCc1ccccc1)C1CCCN1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20030162795A1,O=C1CCC(=O)N1Br.c1ccc(-c2cc3ncnc(Nc4ccc5[nH]ccc5c4)c3s2)cc1>>Brc1c[nH]c2ccc(Nc3ncnc4cc(-c5ccccc5)sc34)cc12,,ClCCl,,,,val
US20140343029A1,Cc1cc(-c2cn(CCO)c(C3CCN(c4ncnc(N)c4-c4cnn(C(=O)OC(C)(C)C)c4)CC3)n2)ccc1F>>Cc1cc(-c2cn(CCO)c(C3CCN(c4ncnc(N)c4-c4cn[nH]c4)CC3)n2)ccc1F,,C1COCCO1,CO,Cl,,val
US05206129,CCCCCCCCCCCCS(=O)(=O)c1ccc(C(=O)Cl)cc1.Cc1nsc(C#N)c1[N+](=O)[O-]>>CCCCCCCCCCCCS(=O)(=O)c1ccc(C(=O)Cc2nsc(C#N)c2[N+](=O)[O-])cc1,,C1CCOC1,,CCN(CC)CC,[Na+].[OH-],val
US20100249085A1,CCOC(=O)C(=O)CC(=O)CC.COC(=O)c1cc(C)n(Cc2ccc(C)cc2)n1>>CCOC(=O)c1cc(CC)n(Cc2ccc(C)cc2)n1,,CC(=O)O,,,,val
US03940458,CN(C)C=O.O=C(Cl)C(Cl)(Cl)Cl>>CN(C)C(=O)C(=O)C(Cl)(Cl)Cl,,O,,CCN(CC)CC,,val
US06071927,FC(F)(F)COc1ccc(OCc2ccccc2)cc1>>Oc1ccc(OCC(F)(F)F)cc1,[Pd],CO,,,,val
US20130190309A1,Nc1cccc2cnn(-c3cccc(C(F)(F)F)c3)c(=O)c12.O=C(O)c1cnccn1>>O=C(Nc1cccc2cnn(-c3cccc(C(F)(F)F)c3)c(=O)c12)c1cnccn1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030050315A1,CN1C(O)c2cccc(Br)c2S1(=O)=O>>CN1C(=O)c2cccc(Br)c2S1(=O)=O,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20130217666A1,C#CC(C)(C)O.NC(=O)c1nc2n(c1C(O)c1ccnn1C1CCCCO1)C1CC(C1)c1cc(F)c(Br)cc1-2>>CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1C(O)c1ccnn1C1CCCCO1,,CN(C)C=O,,CC(C)NC(C)C,,val
US20110130412A1,CCOC(=O)[C@@H](O)[C@@H](NCc1cn(COCc2ccccc2)c2c(OC)ncnc12)C(=O)OCC>>COc1ncnc2c(CN[C@@H](CO)[C@H](O)CO)cn(COCc3ccccc3)c12,,CCOCC,CO,[BH4-].[Li+],,val
US05658908,CC(C)(C)[Si](C)(C)Oc1cccc(C=O)c1.CSc1ccc(Br)cc1>>CSc1ccc(C(O)c2cccc(O[Si](C)(C)C(C)(C)C)c2)cc1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US05804601,CCOC(=O)CCCCCC(=O)[O-].Nc1ccccc1S>>O=C(O)CCCCCc1nc2ccccc2s1,,O,,,,val
US20020103245A1,COc1cccc(Br)c1.Nc1c(C(=S)Oc2ccccn2)cnn1-c1ccc(F)cc1>>COc1cccc(C(=O)c2cnn(-c3ccc(F)cc3)c2N)c1,,C1CCOC1,,[Mg],,val
US05587161,O=C(Nc1ccccc1)N[C@@H](CC(C(=O)OCc1ccccc1)N(CCCl)CCCl)C(=O)OCc1ccccc1>>O=C(Nc1ccccc1)N[C@@H](CC(C(=O)O)N(CCCl)CCCl)C(=O)O,[Pd],CN(C)C=O,,,,val
US06159990,C[C@H]1CN(c2ccccc2[N+](=O)[O-])CCN1CCCN.O=C1OCC(c2ccc(F)c(F)c2)N1C(=O)Oc1ccc([N+](=O)[O-])cc1>>CC1CN(c2ccccc2[N+](=O)[O-])CCN1CCCNC(=O)N1C(=O)OCC1c1ccc(F)c(F)c1,,C1CCOC1,,,,val
US20100010053A1,COc1cc(-c2nc(-c3ccc4c(CCC(=O)[O-])c[nH]c4c3)no2)cnc1OC(C)C>>COc1cc(-c2nc(-c3ccc4c(CCC(=O)O)c[nH]c4c3)no2)cnc1OC(C)C,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20120115841A1,CC(O)c1nc(CCl)cs1>>CC(=O)c1nc(CCl)cs1,O=[Mn]=O,CC#N,,N#N,,val
US20080113946A1,Cc1cc(N)[nH]n1.O=C(OCC1c2ccccc2-c2ccccc21)N1Cc2nc(Cl)nc(Cl)c2C1>>Cc1cc(Nc2nc(Cl)nc3c2CN(C(=O)OCC2c4ccccc4-c4ccccc42)C3)[nH]n1,,CC(C)O,,,,val
US20090291940A1,O=C(N[C@@H]1CN(C(=O)Cc2ccc(OC(F)(F)F)cc2)C[C@H]1O)OCc1ccccc1>>N[C@@H]1CN(C(=O)Cc2ccc(OC(F)(F)F)cc2)C[C@H]1O,[Pd],CO,,,,val
US20060205715A1,NC(=O)c1ccc(Oc2ccc3c(c2)CCC3=O)nc1.NCCCc1ccccc1>>NC(=O)c1ccc(Oc2ccc3c(c2)CCC3NCCCc2ccccc2)nc1,Cl[Ti](Cl)(Cl)Cl,,,[BH3-]C#N.[Na+],,val
US20110201599A1,COCCN(CCOC)S(F)(F)F.Nc1nccc(-c2cn(S(=O)(=O)c3ccccc3)c3nccc(N4CCC[C@H]4CO)c23)n1>>Nc1nccc(-c2c[nH]c3nccc(N4CCC[C@H]4CF)c23)n1,,C1CCOC1,CCOC(C)=O,[Na+].[OH-],,val
US20100137278A1,CC(=O)N1CCC(c2nccnc2F)CC1.Oc1ccc(Nc2nc3ccccc3s2)cc1>>CC(=O)N1CCC(c2nccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040127514A1,CC(C)(C)C(=O)CBr.CCc1cn2c(N)c(Cl)cc(C(=O)NCC3CCNCC3)c2n1>>CCc1cn2c(N)c(Cl)cc(C(=O)NCC3CCN(CC(=O)C(C)(C)C)CC3)c2n1,,CN(C)C=O,,CCN(CC)CC,[I-].[Na+],val
US04496392,CN(C)S(=O)(=O)c1ccccc1S(=O)(=O)N=C=O.COc1nc(CN)nc(OC)n1>>COc1nc(CNC(=O)NS(=O)(=O)c2ccccc2S(=O)(=O)N(C)C)nc(OC)n1,,CC#N,,,,val
US05538986,C=CCC1(C=CCO)c2ccccc2CCc2ccccc21>>CCCC1(CCCO)c2ccccc2CCc2ccccc21,[Pd],CCO,,[H][H],,val
US20130261298A1,COc1cc2c(cc1OC)[C@@H](CN(C)CCCO)C2.O=S(Cl)Cl>>COc1cc2c(cc1OC)[C@@H](CN(C)CCCCl)C2,,ClCCl,O,CCN(CC)CC,[Na+].[OH-],val
US20090130117A1,COc1ccc(C(C)C)cc1-c1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)c(OCc2ccccc2)cc1OCc1ccccc1.C[Si](C)(C)N=[N+]=[N-]>>COc1ccc(C(C)C)cc1-c1cc(-c2nnnn2C2CCN(C(=O)OC(C)(C)C)CC2)c(OCc2ccccc2)cc1OCc1ccccc1,,ClCCl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20120142717A1,COC(=O)/C(=C\O)Cc1cnc(OC)nc1.NC(N)=S>>COc1ncc(Cc2c[nH]c(=S)[nH]c2=O)cn1,,CC(C)O,,,,val
US20160214960A1,COC(=O)c1cc(O[C@@H]2CC[C@@H](C)N(C(=O)c3ccccc3-n3nccn3)C2)ncc1Br.C[Zn]C>>COC(=O)c1cc(O[C@@H]2CC[C@@H](C)N(C(=O)c3ccccc3-n3nccn3)C2)ncc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,,,val
US07060822B1,CN(C)C=O.Cc1cc(C(C)C)c[nH]1>>Cc1cc(C(C)C)c(C=O)[nH]1,,CC(Cl)Cl,O,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US05552422,CS(=O)(=O)c1ccc(C(Br)C(=O)c2ccccc2)cc1.Nc1nccs1>>CS(=O)(=O)c1ccc(-c2c(-c3ccccc3)nc3sccn23)cc1,,CCO,,O=C([O-])O.[Na+],,val
US20150284367A1,CC(C)(C)c1nccc(N)n1.CCOC(=O)c1nnc(Cl)cc1Cl>>CCOC(=O)c1nnc(Cl)cc1Nc1ccnc(C(C)(C)C)n1,,CC#N,,,,val
US20100331366A1,COC(=O)C12CC3CC(C1)C(N)C(C3)C2>>NC1C2CC3CC1CC(CO)(C3)C2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04464373,CCOC(=O)Cl.CCOC(=O)N1Cc2nccn2-c2ccccc21>>CCOC(=O)c1cn2c(n1)CN(C(=O)OCC)c1ccccc1-2,,CN(C)C=O,,,,val
US04997840,CN(C=O)c1cc(Cl)ccc1C(=O)CCl.O=C(O)c1ccccc1>>CN(C=O)c1cc(Cl)ccc1C(=O)COC(=O)c1ccccc1,,CCN(CC)CC,ClCCl,,,val
US20160145218A1,COc1ccc(C[C@H](C)NC(=O)Cn2ncc3c(C)c(C)sc3c2=O)c(Cl)c1>>Cc1sc2c(=O)n(CC(=O)N[C@@H](C)Cc3ccc(O)cc3Cl)ncc2c1C,,ClCCl,,BrB(Br)Br,,val
US04593104,CCc1cccc(C)c1N(CCl)C(=O)CCl.Cc1n[nH]c(C)c1Cl>>CCc1cccc(C)c1N(Cn1nc(C)c(Cl)c1C)C(=O)CCl,,COCCOC,,,,val
US20020147365A1,CCCCCCCCN.COc1cccc(CN=C=S)c1>>CCCCCCCCNC(=S)NCc1cccc(OC)c1,,CCO,,,,val
US20090093483A1,Cc1cccc(Cl)c1I.O=C1CCC(=O)N1Br>>Clc1cccc(CBr)c1I,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20050049274A1,Brc1ccccn1.Nc1ccc(Cl)cc1C(=O)O>>Nc1ccc(Cl)cc1C(=O)c1ccccn1,,C1CCOC1,,[Li]CCCC,,val
US20090239864A1,CN(C)CC(=O)Nc1ccc([C@H]2CNCCO2)cc1.Cn1c(Cl)nc(-c2ccncc2F)cc1=O>>CN(C)CC(=O)Nc1ccc([C@H]2CN(c3nc(-c4ccncc4F)cc(=O)n3C)CCO2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20100144787A1,Cc1c(Cc2ccc(-n3cccn3)cc2)c(C(C)C)nc2c(Cl)ccc(O)c12.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1c(Cc2ccc(-n3cccn3)cc2)c(C(C)C)nc2c(Cl)ccc(OS(=O)(=O)C(F)(F)F)c12,,O=C([O-])O,[Na+],CCN(CC)CC,ClCCl,val
US20030078252A1,Cc1ccc2cc(N)ccc2n1.O=C(Nc1ncc(C2CCC2)s1)Oc1ccccc1>>Cc1ccc2cc(NC(=O)Nc3ncc(C4CCC4)s3)ccc2n1,,C1COCCO1,,,,val
US20100272680A1,CC(C)(C)OC(=O)N1CC[C@@H](N=[N+]=[N-])[C@H](O)C1.CC(C)(C)[Si](C)(C)Cl>>CC(C)(C)OC(=O)N1CC[C@@H](N=[N+]=[N-])[C@H](O[Si](C)(C)C(C)(C)C)C1,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20100029688A1,CC(C)(C)OC(=O)N1CCC(C2CCN(c3cc(Cl)ncn3)CC2)CC1>>CC(C)(C)OC(=O)N1CCC(C2CCN(c3ccncn3)CC2)CC1,[Pd],CO,O,CC(=O)[O-].[Na+],,val
US20160251321A1,CI.Cc1cc(F)c(-n2ncc(=O)[nH]c2=O)cc1SCC(F)(F)F>>Cc1cc(F)c(-n2ncc(=O)n(C)c2=O)cc1SCC(F)(F)F,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20050159462A1,Cc1cccc2oc(-c3ccc(Cl)cc3)nc12.O=C1CCC(=O)N1Br>>Clc1ccc(-c2nc3c(CBr)cccc3o2)cc1,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,,,val
US04820703,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccc(CCc2cc3c(s2)NC(=O)CN=C3c2ccccc2Cl)cc1>>Cc1ccc(CCc2cc3c(s2)NC(=S)CN=C3c2ccccc2Cl)cc1,,Cc1ccccc1,,,,val
US20090208485A1,CC(C)(C)OC(=O)N1CC=C(c2cncc(C(F)(F)F)c2)CC1>>FC(F)(F)c1cncc(C2=CCNCC2)c1,,C1COCCO1,Cl,,,val
US20060172994A1,CC(C)(C)OC(=O)N1CCNCC1.Clc1nccc2ccccc12>>CC(C)(C)OC(=O)N1CCN(c2nccc3ccccc23)CC1,,O,,C1CCC2=NCCCN2CC1,,val
US05635510,BrCc1ccccc1.N#CC1(c2ccccc2)CCNCC1>>N#CC1(c2ccccc2)CCN(Cc2ccccc2)CC1,,C1CCOC1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20040241795A1,CCOC(=O)C(CCC(=O)OC(C)(C)C)C(=O)OCC>>CCOC(=O)C(CCC(=O)O)C(=O)OCC,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110166139A1,CC(C)I.Cc1n[nH]cc1[N+](=O)[O-]>>Cc1nn(C(C)C)cc1[N+](=O)[O-],,CN(C)C=O,ClCCl,O,O=C([O-])[O-].[K+].[K+],val
US20110028445A1,CC1(C)[C@H]2Cc3cc(N)c(N)cc3[C@]1(C)CCN2C(=O)C(F)(F)F.O=N[O-]>>CC1(C)[C@H]2Cc3cc4nn[nH]c4cc3[C@]1(C)CCN2C(=O)C(F)(F)F,,O,,CC(=O)O,,val
US07495007B2,C=C(Br)[C@@H]1NC(=O)C[C@@H](c2cccc(Cl)c2)[C@]12C(=O)N(C(=O)OC(C)(C)C)c1cc(Cl)ccc12>>C=C(Br)[C@@H]1NC(=O)C[C@@H](c2cccc(Cl)c2)[C@]12C(=O)Nc1cc(Cl)ccc12,,O=C(O)C(F)(F)F,,,,val
US20130131050A1,CCOC(=O)CCC(C(=N)N)C(=O)OCC.FC(F)(F)COc1ccc(N=C=S)cc1>>O=C1CCc2c([nH]c(=S)n(-c3ccc(OCC(F)(F)F)cc3)c2=O)N1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20050038035A1,CC(=O)Nc1cccc(CN2CCN(c3ccc(NC(=O)C4=C(c5ccc(C)cc5)CCCC4)cc3)CC2)n1>>Cc1ccc(C2=C(C(=O)Nc3ccc(N4CCN(Cc5cccc(N)n5)CC4)cc3)CCCC2)cc1,,CO,,Cl,,val
US20100280063A1,C=COCCONC(=O)c1ccn2cncc2c1Nc1ccc(C2CC2)cc1F>>O=C(NOCCO)c1ccn2cncc2c1Nc1ccc(C2CC2)cc1F,,CO,ClCCl,,,val
US04443448,Cc1ccc2c(c1)C(=O)CC2c1ccc(F)cc1>>Cc1ccc2c(c1)C(O)CC2c1ccc(F)cc1,,CO,,[BH4-].[Na+],,val
US04187311,CCOC(=O)CBr.Fc1ccccc1Oc1cccnc1>>CCOC(=O)C[n+]1cccc(Oc2ccccc2F)c1.[Br-],,CC#N,,,,val
US20160152599A1,COc1cc(-n2cc(C(=O)N(c3ccccc3)c3ccc(OC(=O)CSc4ccccc4)cc3)c3ccccc32)c(C(=O)N2Cc3ccccc3C[C@H]2CNC(=O)OC(C)(C)C)cc1NC(=O)CSc1ccccc1>>COc1cc(-n2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3ccccc32)c(C(=O)N2Cc3ccccc3C[C@H]2CN)cc1NC(=O)CSc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20040142996A1,CC1(C)OCC(CCCN)O1.CCOC(=O)c1cccc2c1C(=O)NC2=O>>CC1(C)OCC(CCCN2C(=O)c3ccccc3C2=O)O1,,CC#N,,CCN(CC)CC,,val
US20160002177A1,C[Si](C)(C)CCOCOc1cc(-c2ccc(S(F)(F)(F)(F)F)cc2)cc2c(=O)n(COCC[Si](C)(C)C)cnc12>>O=c1[nH]cnc2c(O)cc(-c3ccc(S(F)(F)(F)(F)F)cc3)cc12,,O=CO,,O,,val
US20090082339A1,CN1CCCN(c2ccc(N)cc2)CC1.COC(=O)c1sc(Br)cc1N=CN(C)C>>CN1CCCN(c2ccc(-n3cnc4cc(Br)sc4c3=O)cc2)CC1,,CC(C)O,,,,val
US04134983,ClCC1CO1.O=Cc1c(Cl)cc(O)cc1Cl>>O=Cc1c(Cl)cc(OCC2CO2)cc1Cl,,[Na+],[OH-],,,val
US20100305122A1,C=CC1(O)CCOCC1.COS(=O)(=O)OC>>C=CC1(OC)CCOCC1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20100305133A1,O=C(O)CNC(=O)c1c(O)c(C2=CCCCC2)cc2ncc(-c3ccc(F)c(F)c3)nc12>>O=C(O)CNC(=O)c1c(O)c(C2CCCCC2)cc2ncc(-c3ccc(F)c(F)c3)nc12,[Pd],C1CCOC1,CO,[H][H],,val
US20030036652A1,CC(=O)O.Nc1ccc(S(=O)(=O)C(F)(F)F)cc1>>CC(=O)Nc1ccc(S(=O)(=O)C(F)(F)F)cc1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20130211075A1,Cc1c(C(=O)Cl)cnn1-c1ccc(C(F)(F)F)cn1.Nc1ccc(Cl)nc1.c1ccncc1>>Cc1c(C(=O)Nc2cnc(Cl)nc2)cnn1-c1ccc(C(F)(F)F)cn1,,O,,Cc1ccccc1,,val
US05223529,Nc1cccc([N+](=O)[O-])c1.O=C(CNC(=O)n1ccnc1)N(c1ccccc1)c1ccccc1>>O=C(NCC(=O)N(c1ccccc1)c1ccccc1)Nc1cccc([N+](=O)[O-])c1,,Cc1ccccc1,,,,val
US04237138,COC(C)COC1CCNCC1.COc1cc2nc(Cl)nc(N)c2cc1OC>>COc1cc2nc(N3CCC(OCC(C)OC)CC3)nc(N)c2cc1OC.Cl,,CCCCO,,CCN(CC)CC,,val
US20120171199A1,Clc1nc(N2CCOCC2)c2nc(CCCCBr)n(C3CCCCO3)c2n1>>Clc1nc(N2CCOCC2)c2nc(CCCCBr)[nH]c2n1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100120761A1,CC1(C)OB(c2cccc(N=C=O)c2)OC1(C)C.NCC(F)(F)CN>>CC1(C)OB(c2cccc(NC(=O)NCC(F)(F)CN)c2)OC1(C)C,,C1CCOC1,,CCN(CC)CC,,val
US20110152240A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(CNc1cc(Cl)nc2ccnn12)N1CCOCC1>>CC(CN(C(=O)OC(C)(C)C)c1cc(Cl)nc2ccnn12)N1CCOCC1,,ClCCl,,CCN(CC)CC,CN(C)c1ccccn1,val
US20090197863A1,O=C(O)c1cccc(Cl)c1[N+](=O)[O-].[OH-]>>O=C(O)c1cccc(O)c1[N+](=O)[O-],,O,,Cl,,val
US20140206680A1,CC(C)(C)OC(=O)N[C@H]1COCC[C@H]1Nc1nc(Cl)c2c(c1F)CN(C(=O)OC(C)(C)C)C2=O.CCCC[Sn](CCCC)(CCCC)c1ccns1>>CC(C)(C)OC(=O)N[C@H]1COCC[C@H]1Nc1nc(-c2ccns2)c2c(c1F)CN(C(=O)OC(C)(C)C)C2=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O,,val
US20090221555A1,Clc1ncc(Cl)c(Cl)n1.Nc1ccccc1-c1nc(C(F)(F)F)c[nH]1>>FC(F)(F)c1c[nH]c(-c2ccccc2Nc2nc(Cl)ncc2Cl)n1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20150111885A1,O=[N+]([O-])c1cnc(Cl)c(Br)c1.OCC1CC1>>O=[N+]([O-])c1cnc(OCC2CC2)c(Br)c1,,C1CCOC1,,O,CC(C)(C)[O-].[K+],val
US06586441B2,CN1c2ccccc2CCC1CN.CS(=O)c1nc(N)nc(-c2ccco2)c1C#N>>CN1c2ccccc2CCC1CNc1nc(N)nc(-c2ccco2)c1C#N,,COCCOC,,C1CCC2=NCCCN2CC1,Cl,val
US20130040933A1,C[C@H](Nc1cncc(-c2cn(S(=O)(=O)c3ccccc3)c3ncc(Cl)cc23)n1)C(=O)OC(C)(C)C>>C[C@H](Nc1cncc(-c2cn(S(=O)(=O)c3ccccc3)c3ncc(Cl)cc23)n1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150065499A1,CC(=O)CCl.COc1cc2ncc(C#N)c(S)c2cc1OC>>COc1cc2ncc3c(N)c(C(C)=O)sc3c2cc1OC,,CO,,[Na+].[OH-],,val
US05130322,COCC1(C)C=C(n2ccccc2=O)c2cc(C(N)=O)ccc2O1>>COCC1(C)CC(n2ccccc2=O)c2cc(C(N)=O)ccc2O1,[Pd],,,,,val
US20010006969A1,C=CCNc1nc(N)c2scc(C)c2n1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCN>>C=CCNc1nc(NC(=O)NCCCC)c2scc(C)c2n1,,CC#N,,CCCCCC,CCOC(C)=O,val
US20080221180A1,CC(=O)Nc1nc(C)c(-c2cc(S(=O)(=O)Cl)sc2Br)s1.CN(C(=O)OC(C)(C)C)C1CCNCC1>>CC(=O)Nc1nc(C)c(-c2cc(S(=O)(=O)N3CCC(N(C)C(=O)OC(C)(C)C)CC3)sc2Br)s1,,ClCCl,,CCN(CC)CC,,val
US20150218096A1,Br[Mg]C1CC1.COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C=O)cnc23)c(F)c1>>COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C(O)C4CC4)cnc23)c(F)c1,,C1CCOC1,,O,,val
US20090118169A1,COC(=O)Cc1ccccc1OCC(C)C.COC(Cl)Cl.O>>COC(=O)Cc1cc(C=O)ccc1OCC(C)C,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20150045554A1,CC(C)(N)C#N.ClCCl.O=C(Cl)c1conn1>>Cc1nnc(C(=O)NC(C)(C)C#N)o1,,ClCCl,,CN1CCOCC1,,val
US20080070935A1,CC(=O)c1cnc(N)c2ccc(F)cc12.Cc1c[nH]c2c1C(=O)CC(C)(C)C2>>CC(=O)c1cnc(N)c2ccc(-n3cc(C)c4c3CC(C)(C)CC4=O)cc12,,CC(=O)N(C)C,,[H-].[Na+],[Cl-].[NH4+],val
US20070213341A1,C=C(N=Cc1cccc(Cl)c1)O[Si](C)(C)C.CC(C)(C)/C=C1/C(=O)Nc2cc(Cl)ccc21>>CC(C)(C)C1CC(=O)NC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12,,Cc1ccccc1,,,,val
US20150291632A1,Fc1cc(Cl)ccc1CBr.O=Cc1ccc(-c2ccc(OC(F)(F)F)cc2)cn1>>OC(Cc1ccc(Cl)cc1F)c1ccc(-c2ccc(OC(F)(F)F)cc2)cn1,,CCOCC,,,,val
US04182865,Cn1ccnc1N.S=C=Nc1ccccc1>>Cn1ccnc1NC(=S)Nc1ccccc1,,ClCCl,,Cl,[Na+].[OH-],val
US20160222014A1,CI.COC(=O)c1ccccc1NS(C)(=O)=O>>COC(=O)c1ccccc1N(C)S(C)(=O)=O,,CN(C)C=O,,[H-].[Na+],,val
US20070265345A1,Nc1ccc(-c2ccc(C(F)(F)F)cc2)cc1.O=COc1ccc([N+](=O)[O-])cc1>>O=CNc1ccc(-c2ccc(C(F)(F)F)cc2)cc1,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US20040082571A1,Cc1n[nH]c(C)c1I.O=C(CCl)N1CCN(c2ccc(F)cc2)CC1>>Cc1nn(CC(=O)N2CCN(c3ccc(F)cc3)CC2)c(C)c1I,,CCCCCC,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04782105,CCCCCCCCCCCCCCNCCCCCCCCCCCCCC.OO>>CCCCCCCCCCCCCCN(O)CCCCCCCCCCCCCC,,CCCO,,,,val
US20140275004A1,CCOC(=O)C1CCC(N2CC=C(c3cc4c(-c5cc(F)ccc5OC)ncnc4[nH]3)CC2)CC1>>COc1ccc(F)cc1-c1ncnc2[nH]c(C3=CCN(C4CCC(C(=O)O)CC4)CC3)cc12,,C1CCOC1,O,[Li+].[OH-],,val
US20110053929A1,CC(=O)N[C@@H](C)C(=O)O.CCOC(C)=O>>CCOC(=O)C(=O)C(C)NC(C)=O,CN(C)c1ccncc1,C1CCOC1,,c1ccncc1,,val
US20090318475A1,COC(=O)CCCCCNc1ncnc2oc(Br)c(-c3ccc(OC)cc3)c12.OB(O)c1ccccc1C(F)(F)F>>COC(=O)CCCCCNc1ncnc2oc(-c3ccccc3C(F)(F)F)c(-c3ccc(OC)cc3)c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20140235620A1,Cc1nn(Cc2ccccc2)cc1[C@H](C)N[S@](=O)C(C)(C)C.Cl>>Cc1nn(Cc2ccccc2)cc1[C@H](C)N.Cl,,C1COCCO1,,,,val
US20070167488A1,CCOC(=O)c1cc(C)c(C=O)[nH]1.O=C1Cc2ccccc2N1>>CCOC(=O)c1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1,,CCO,,C1CCNCC1,,val
US20120003790A1,CC1(C)c2cc(N(c3ccc(C4OCCO4)cc3)c3cccc4ccccc34)ccc2-c2ccc(N(c3ccc(C4OCCO4)cc3)c3cccc4ccccc34)cc21>>CC1(C)c2cc(N(c3ccc(C=O)cc3)c3cccc4ccccc34)ccc2-c2ccc(N(c3ccc(C=O)cc3)c3cccc4ccccc34)cc21,,CC(C)=O,,Cl,,val
US20060142312A1,CS(=O)(=O)Cl.O=c1c(Cc2ccccn2)cc2cnc(NC3CCNCC3)nc2n1C1CCCC1>>CS(=O)(=O)N1CCC(Nc2ncc3cc(Cc4ccccn4)c(=O)n(C4CCCC4)c3n2)CC1,,ClCCl,,CCN(CC)CC,,val
US20020193382A1,Clc1ccncc1.OC1CCNCC1>>OC1CCN(c2ccncc2)CC1,,CC(C)CCO,,Cl,O=C([O-])O.[Na+],val
US06048882,CC(C)=CCCC(C)=CCCC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CBr.NCc1ccc2c(c1)OCO2>>CC(C)=CCCC(C)=CCCC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CNCc1ccc2c(c1)OCO2,,C1CCOC1,,O,,val
US20110152295A1,CCOC(=O)Cn1nnc(-c2cncc(-c3cn(Cc4cc(Br)c(Br)c(Br)c4)nn3)c2)n1>>O=C(O)Cn1nnc(-c2cncc(-c3cn(Cc4cc(Br)c(Br)c(Br)c4)nn3)c2)n1,,C1CCOC1,,[Na+].[OH-],,val
US20060235030A1,Cc1ccc(C(=O)Nc2ccc(F)cc2)cc1-c1nc(NCCN(CC(C)(C)C)C(=O)[O-])nc2c1CNC(=O)N2c1c(F)cccc1F>>CNCCNc1nc(-c2cc(C(=O)Nc3ccc(F)cc3)ccc2C)c2c(n1)N(c1c(F)cccc1F)C(=O)NC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140187553A1,COS(=O)(=O)OC.O=C(O)c1ccc2[nH]ccc2c1>>COC(=O)c1ccc2[nH]ccc2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110263556A1,CC1(C(=O)O)CCCCC1.Cc1ccc(CN)cc1C(=O)O>>Cc1ccc(CNC(=O)C2(C)CCCCC2)cc1C(=O)O,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20070043095A1,Br.CC(=O)c1cc2ccccc2o1>>O=C(CBr)c1cc2ccccc2o1,,CO,,c1ccncc1,,val
US04568675,COc1ccc(N)c(C)c1.COc1ccccc1[N+](=O)[O-]>>COc1cc(C)c2nc3cccc(OC)c3nc2c1,,Cc1ccccc1,,[K+].[OH-],,val
US04379167,COc1ccccc1O.OC(CCl)CCCl>>COc1ccccc1OCC(O)CCCl,,CC(C)O,,O,[Na+].[OH-],val
US20140329871A1,COC(=O)Cc1ccc(-c2ccc(-c3ncn(C)c3NC(=O)O[C@H](C)c3ccccc3)cc2)cc1>>C[C@@H](OC(=O)Nc1c(-c2ccc(-c3ccc(CC(=O)O)cc3)cc2)ncn1C)c1ccccc1,,C1CCOC1,CCO,O,[Li+].[OH-],val
US20140206681A1,CC1(C)CC(=O)N2CC(c3ncc4c(Cl)nccn34)CCC21.O=C1CCC(=O)N1Br>>CC1(C)CC(=O)N2CC(c3nc(Br)c4c(Cl)nccn34)CCC21,,CC#N,,,,val
US20130211075A1,CC(C)(C)OC(=O)N1CCCC(=O)CC1.Cc1cc(Br)cnc1Br>>Cc1cc(Br)cnc1C1(O)CCCN(C(=O)OC(C)(C)C)CC1,,CCCCCC,Cc1ccccc1,[Li]CCCC,[Cl-].[NH4+],val
US20080153805A1,COc1ccc(Cl)cc1S(=O)(=O)Cl.O=[N+]([O-])c1ccc2c(c1)NCCC2>>COc1ccc(Cl)cc1S(=O)(=O)N1CCCc2ccc([N+](=O)[O-])cc21,,ClCCl,,c1ccncc1,,val
US20040110787A1,CCOC(=O)c1cnc2sc(CO)cc2c1O.CI>>CCOC(=O)c1cn(C)c2sc(CO)cc2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050096343A1,CC(=O)NC[C@H]1CN(c2ccc(NC3CCNC3)c(F)c2)C(=O)O1.O=C(O)c1cn(C2CC2)c2nc(Cl)c(F)cc2c1=O>>CC(=O)NC[C@H]1CN(c2ccc(N[C@@H]3CCN(c4nc5c(cc4F)c(=O)c(C(=O)O)cn5C4CC4)C3)c(F)c2)C(=O)O1,,CS(C)=O,,CCN(CC)CC,C[Si](C)(C)Cl,val
US20100009958A1,C#Cc1cccc(Nc2ncnc3ccc(N)cc23)c1.O=C(Cl)Oc1ccccc1>>C#Cc1cccc(Nc2ncnc3ccc(NC(=O)Oc4ccccc4)cc23)c1,,CCOC(C)=O,CN(C)C=O,c1ccncc1,,val
US20100240661A1,COC(CCBr)OC.Cc1n[nH]c(=O)n(C(=O)c2ccccc2)c1=O>>COC(CCn1nc(C)c(=O)n(C(=O)c2ccccc2)c1=O)OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020025960A1,C1COCCN1.CCOC(=O)c1cnc2sc(CBr)cn2c1=O>>CCOC(=O)c1cnc2sc(CN3CCOCC3)cn2c1=O,,CN(C)C=O,ClCCl,,,val
US20030013656A1,CC(C)(S)[C@H](N)C(=O)O.CCOC(=O)C(=O)CBr>>CC1(C)SC=C(C(=O)O)NC1C(=O)O,,CC#N,O,O=C([O-])O.[Na+],,val
US20150166565A1,CCOC(=O)Cc1nc(N(C)C2CC2)c2c3c(sc2n1)CCCC3>>CN(c1nc(CC(=O)O)nc2sc3c(c12)CCCC3)C1CC1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20030013721A1,CC(C)(C)OC(=O)N1C2CCC1CN(CC(=O)Nc1cccc3c1CC(=O)N3)C2.Cl>>Cl.O=C1Cc2c(cccc2NC(=O)CN2CC3CCC(C2)N3)N1,,C1COCCO1,,CO,,val
US20030162764A1,O=C(CBr)Nc1cc(Cl)nc(-c2ccccc2)n1.O=[N+]([O-])c1cc(C(F)(F)F)ccc1N1CCNCC1>>O=C(CN1CCN(c2ccc(C(F)(F)F)cc2[N+](=O)[O-])CC1)Nc1cc(Cl)nc(-c2ccccc2)n1,,CC#N,,,,val
US20130267520A1,C1COCCO1.CC(c1ccccc1)n1ncc(Cl)c(Cl)c1=O.COc1ccc(B(O)O)cc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COc1ccc(-c2cnn(C(C)c3ccccc3)c(=O)c2-c2ccc(OC)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US04031226,C1CN1.COc1cc([N+](=O)[O-])c(Cl)cc1C(=O)Cl>>COc1cc([N+](=O)[O-])c(Cl)cc1C(=O)N1CC1,,ClC(Cl)Cl,O,[Na+].[OH-],,val
US20090137499A1,CCc1ccc(Cc2c(C)cc(COC(C)=O)cc2O[C@@H]2O[C@H]([C@@H](C)OC(=O)c3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@H](OC(=O)c3ccccc3)[C@H]2OC(=O)c2ccccc2)cc1>>CCc1ccc(Cc2c(C)cc(CO)cc2O[C@@H]2O[C@H]([C@@H](C)O)[C@@H](O)[C@H](O)[C@H]2O)cc1,,C1CCOC1,CO,O=C([O-])[O-].[K+].[K+],,val
US06080754,C#CC(=O)OC.CCc1c(-c2ccc(OCc3ccccc3)cc2)cn2cc(NC(C)=O)ccc12>>CCc1c(-c2ccc(OCc3ccccc3)cc2)c2cc(C(=O)OC)c3c(NC(C)=O)ccc1n23,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20040092737A1,CCOP(OCC)OCC.ClCc1ccc2c(c1)Nc1nccnc1S2>>CCOP(=O)(OCC)c1ccc2c(c1)Nc1nccnc1S2,,CCCCCC,,CCOCC,,val
US20080194633A1,CCc1ccc(N=C=O)cc1.O=C(NCc1ccccc1Cl)N(CCO)CCO>>CCc1ccc(NC(=O)OCCN(CCO)C(=O)NCc2ccccc2Cl)cc1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20150152047A1,CC(C)(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCC[C@H](N)C2)c(C(F)(F)F)c1>>CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCC[C@H](NC(=O)C(C)(C)NC(=O)OCC3c4ccccc4-c4ccccc43)C2)c(C(F)(F)F)c1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100130538A1,CCOC(=O)CP(=O)(OCC)OCC.O=Cc1cccc2nnsc12>>CCOC(=O)/C=C/c1cccc2nnsc12,,C1CCOC1,,O,[H-].[Na+],val
US20080194549A1,COc1ccc(Br)cc1O.O=S(=O)(OCCCOC(F)(F)F)C(F)(F)F>>COc1ccc(Br)cc1OCCCOC(F)(F)F,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20030087901A1,COc1ccc2c(c1)C(=O)N(c1ccc(F)cc1)C2Cc1ccc(OCCC2CCCCN2)cc1>>COc1ccc2c(c1)CN(c1ccc(F)cc1)C2Cc1ccc(OCCC2CCCCN2)cc1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20120128686A1,CCOc1cc(C(N)=O)ccc1Nc1ncnc2sc(C(=O)OC)c(C)c12.N>>CCOc1cc(C(N)=O)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12,,CO,N,[Cl-].[NH4+],,val
US20070265265A1,Nc1nc(-c2cccc([N+](=O)[O-])c2)cs1.O=C(O)[C@@H]1CCCN1C(=O)OCc1ccccc1>>O=C(Nc1nc(-c2cccc([N+](=O)[O-])c2)cs1)C1CCCN1C(=O)OCc1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100280024A1,CC(C)(C)OC(=O)N1CCCC(O)C1.CI>>COC1CCCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,O,[H-].[Na+],,val
US20150031685A1,CN[C@H](CN1CC[C@H](O[Si](C)(C)C(C)(C)C)C1)c1cccc(Br)c1.O=C(Cl)OCc1ccccc1>>CN(C(=O)OCc1ccccc1)[C@H](CN1CC[C@H](O[Si](C)(C)C(C)(C)C)C1)c1cccc(Br)c1,,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100184607A1,CC(=O)C1C(=O)CC(C)(C)CC1=O.N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O>>CC(N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O)=C1C(=O)CC(C)(C)CC1=O,,CO,,Cl,,val
US20140187545A1,BrP(Br)Br.OCc1cccc(Cl)c1Cl>>Clc1cccc(CBr)c1Cl,,Cc1ccccc1,,,,val
US05256675,Nc1ccc(Sc2cnc(N)s2)cc1.O=C(OO)c1cccc(Cl)c1>>Nc1ccc(S(=O)c2cnc(N)s2)cc1,,CN(C)C=O,ClC(Cl)Cl,,,val
US20090239854A1,C=Cc1ccc(CO)nc1.CN1CCc2[nH]c3ccc(C(=O)O)cc3c2C1>>CN1CCc2c(c3cc(C(=O)O)ccc3n2CCc2ccc(CO)nc2)C1,,CN1CCCC1=O,,[K+].[OH-],,val
US20140073620A1,CC(C)(C)OC(=O)N1CC(n2cc(N)cn2)C1.NC(=O)C1(c2ccccc2CCc2nc(Cl)ncc2Cl)CC1>>CC(C)(C)OC(=O)N1CC(n2cc(Nc3ncc(Cl)c(CCc4ccccc4C4(C(N)=O)CC4)n3)cn2)C1,,C1COCCO1,,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20100298384A1,CC(=O)CCl.CC(=O)NCC1CN(c2ccc(-n3cnc(CC(N)=S)c3)c(F)c2)C(=O)O1>>CC(=O)NC[C@H]1CN(c2ccc(-n3cnc(Cc4nc(C)cs4)c3)c(F)c2)C(=O)O1,,CCO,,,,val
US20040192688A1,CCOC(=O)CBr.COc1ccc(NCCCOc2ccc3ccccc3c2)cc1>>CCOC(=O)CN(CCCOc1ccc2ccccc2c1)c1ccc(OC)cc1,,CC(C)=O,,,,val
US20070129368A1,COC(=O)C(=O)Nc1ccc2c(c1)C(C)(C)CCC2(C)C>>CC1(C)CCC(C)(C)c2cc(NC(=O)C(=O)O)ccc21,,CO,,[K+].[OH-],,val
US20110006291A1,Brc1cccc(Br)c1.c1ccc2c(c1)[nH]c1ccncc12>>Brc1cccc(-n2c3ccccc3c3cnccc32)c1,[Cu],ClC(Cl)Cl,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20120232052A1,CC(C)(C)OC(=O)NCc1ccnc(C(=O)N2CCC(Oc3ccc(Cl)cc3)CC2)c1>>NCc1ccnc(C(=O)N2CCC(Oc3ccc(Cl)cc3)CC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090209607A1,CC(C)(C)OC(=O)NCC(N)c1ccccc1.O=C(O)c1ccc(Br)s1>>CC(C)(C)OC(=O)NCC(NC(=O)c1ccc(Br)s1)c1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20040077619A1,CNC.ClCCCn1c2ccccc2c2ccccc21>>CN(C)CCCn1c2ccccc2c2ccccc21,,CC#N,,Cl,[I-].[K+],val
US20100093690A1,Cc1nc(N)sc1-c1ccc(S(C)(=O)=O)c(F)c1.O=C(Cl)Cl>>Cc1nc(N=C=O)sc1-c1ccc(S(C)(=O)=O)c(F)c1,,CC#N,,,,val
US05998436,CCOC(=O)c1cn(-c2nc(N)c(F)cc2C)c2c(Cl)c(F)c(F)cc2c1=O>>Cc1cc(F)c(N)nc1-n1cc(C(=O)O)c(=O)c2cc(F)c(F)c(Cl)c21,,O,,CC(=O)O,Cl,val
US20100075948A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1.NCC1CCOCC1>>CC(C)(C)CC1NC(C(=O)NCC2CCOCC2)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130089512A1,NC1CCOCC1.Nc1ncc(Br)nc1Br>>Nc1ncc(Br)nc1NC1CCOCC1,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US05080827,CCCCOC[C@H](C)O.Cc1ccc(S(=O)(=O)Cl)cc1>>CCCCOC[C@H](C)OS(=O)(=O)c1ccc(C)cc1,,c1ccncc1,,Cc1ccccc1,,val
US05198014,N#Cc1cnn(-c2ncc(C(F)(F)F)cc2Cl)c1C=CC(=O)Cl.NS(=O)(=O)Cc1ccccc1>>N#Cc1cnn(-c2ncc(C(F)(F)F)cc2Cl)c1C=CC(=O)NS(=O)(=O)Cc1ccccc1,,C1CCOC1,,O,[H-].[Na+],val
US20110071150A1,BrBr.CCC(=O)c1ccc([N+](=O)[O-])cc1>>CC(Br)C(=O)c1ccc([N+](=O)[O-])cc1,,ClC(Cl)(Cl)Cl,,,,val
US20060264474A1,CCn1nc(C(OC)OC)cc1-c1cccc(C#N)c1>>CCn1nc(C=O)cc1-c1cccc(C#N)c1,,C1CCOC1,,O,O=C(O)C(F)(F)F,val
US20090286768A1,OB(O)c1ccccc1.Oc1ccc(Br)c(Cl)c1>>Clc1cc(Oc2ccccc2)ccc1Br,,ClCCl,,,,val
US20130310379A1,N#Cc1c(F)cccc1-c1ccncn1.O=C(O)c1ccc(O)c(Cl)c1>>N#Cc1c(Oc2ccc(C(=O)O)cc2Cl)cccc1-c1ccncn1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060106012A1,CC(C)(C)OC(=O)N1CCC(Nc2ccc(S(=O)(=O)c3ccccc3)cc2O)CC1.ClCCBr>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(S(=O)(=O)c3ccccc3)cc2OCCCl)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05654326,COC(=O)C(C)Oc1cccc2c1c(C(=O)C(N)=O)c(C)n2Cc1ccccc1>>Cc1c(C(=O)C(N)=O)c2c(OC(C)C(=O)O)cccc2n1Cc1ccccc1,,CO,,[Na+].[OH-],,val
US20080293713A1,C[Si](C)(C)CCO.O=C(O)C1CCCCC1>>C[Si](C)(C)CCOC(=O)C1CCCCC1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US05696122,COc1cc2c(cc1N1CCN(C(=O)OC(C)(C)C)CC1)NCC2.Cc1cc(C(=O)Cl)ccc1Br>>COc1cc2ccn(C(=O)c3ccc(Br)c(C)c3)c2cc1N1CCN(C)CC1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20120028959A1,COC(=O)c1cc(OC)cc([N+](=O)[O-])c1N>>COC(=O)c1cc(OC)cc(N)c1N,[Pd],CO,,[H][H],,val
US05795986,Cl.O=C1COCCN1CCn1c2ccccc2c2c(N3CCCC3)nc(N3CCCC3)nc21>>Cl.O=C1COCCN1CCn1c2ccccc2c2c(N3CCCC3)nc(N3CCCC3)nc21,,CCO,,,,val
US04254135,CCN1C[C@@H](N(C)C(=O)c2ccc([N+](=O)[O-])cc2)[C@H](O)C1>>CCN1C[C@@H](N(C)C(=O)c2ccc(N)cc2)[C@H](O)C1,O=[Pt],CCO,,[H][H],,val
US20100256156A1,Cc1sc(-c2ccc(C(F)(F)F)cc2)cc1C(O)C1CCCCC1.O=S(Cl)Cl>>Cc1sc(-c2ccc(C(F)(F)F)cc2)cc1C(Cl)C1CCCCC1,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20150141406A1,CC1(C)OB(c2ccc(S(N)(=O)=O)cc2)OC1(C)C.COc1nccc2c1c(OS(=O)(=O)C(F)(F)F)nn2C1CCCC1>>COc1nccc2c1c(-c1ccc(S(N)(=O)=O)cc1)nn2C1CCCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US20090041723A1,Cn1cc(C#Cc2ccc(NC(=O)C3COCCN3C(=O)C(N)c3ccccc3)cc2)c(-c2cc(Cl)ccc2O)n1.O=C(O)C1CC1>>Cn1cc(C#Cc2ccc(NC(=O)C3COCCN3C(=O)C(NC(=O)C3CC3)c3ccccc3)cc2)c(-c2cc(Cl)ccc2O)n1,,ClCCl,,CC(C)N=C=NC(C)C,,val
US20150359225A1,CC(=O)OC(C)=O.COc1ccc(S(=O)(=O)n2cc(F)c(N)nc2=O)cc1>>COc1ccc(S(=O)(=O)n2cc(F)c(=NC(C)=O)[nH]c2=O)cc1,,CC#N,,c1ccncc1,,val
US20090247474A1,CC(C)(C)OC(=O)N[C@@H]1CCN(C2CCC(O)(c3ccccn3)CC2)C1.Cl>>Cl.N[C@@H]1CCN(C2CCC(O)(c3ccccn3)CC2)C1,,C1COCCO1,,,,val
US04764202,O=C(Nc1ccnn1-c1c(Cl)cc(C(F)(F)F)c(Cl)c1Cl)C(Cl)Cl.O=[N+]([O-])O>>O=C(Nc1c([N+](=O)[O-])cnn1-c1c(Cl)cc(C(F)(F)F)c(Cl)c1Cl)C(Cl)Cl,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20110118236A1,CCOC(=O)c1sc(SC)c2c1CN(C)C2=O>>CSc1sc(C(=O)O)c2c1C(=O)N(C)C2,,CCO,,Cl,[Na+].[OH-],val
US20100184809A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(N(C)Cc2ccc(C(=O)O)cc2)c(C(F)(F)F)n1.OCC(O)CO>>CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(N(C)Cc2ccc(C(=O)OCC(O)CO)cc2)c(C(F)(F)F)n1,,CC#N,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20070213323A1,COc1ccc(-c2nc3ccccc3s2)cn1.Fc1cc(CBr)ccc1Cl>>O=c1ccc(-c2nc3ccccc3s2)cn1Cc1ccc(Cl)c(F)c1,,CC#N,,[I-].[Na+],,val
US20120095064A1,Cc1cc(N2C(=O)c3ccccc3C2=O)n[nH]1.Fc1cccc(Cl)c1CBr>>Cc1cc(N2C(=O)c3ccccc3C2=O)nn1Cc1c(F)cccc1Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05698554,CS(=O)CCS(=O)(=O)NCCCc1ccc(-c2ccc(=O)[nH]n2)cc1>>C=CS(=O)(=O)NCCCc1ccc(-c2ccc(=O)[nH]n2)cc1,,OCCO,,,,val
US20110077400A1,CN.COc1cccc(C=O)c1>>CNCc1cccc(OC)c1,,CO,,[BH4-].[Na+],,val
US04636513,C1CCNCC1.Cc1oncc1C(=O)Cl>>Cc1oncc1C(=O)N1CCCCC1,,O,,[Na+].[OH-],,val
US20160031871A1,CC1CC(Cc2ccccc2)CCN1C(=O)OC(C)(C)C.Cl>>CC1CC(Cc2ccccc2)CCN1.Cl,,C1COCCO1,,,,val
US05998433,C=O.CNC.O=C(c1ccc(-c2ccccc2)cc1)N1CCc2ccoc2C1>>CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc(-c3ccccc3)cc1)CC2,,CC(=O)O,,,,val
US20110028492A1,CC1(CN)CCOCC1.Fc1cccc(Br)n1>>CC1(CNc2cccc(Br)n2)CCOCC1,,CCOC(C)=O,CS(C)=O,CCN(CC)CC,,val
US20130079341A1,Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1C(=O)CSC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1C(=O)CS,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US04684648,CCOC(=O)c1cn(-c2ccc(OC)cc2)c2cc(F)c(F)cc2c1=O>>COc1ccc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)cc32)cc1,,CC(=O)O,,Cl,,val
US05162315,CCCCCCCCCCCC(=O)Cl.NCCOCCO>>CCCCCCCCCCCC(=O)NCCOCCO,,CCN(CC)CC,ClCCl,,,val
US20150210705A1,CC(C)Nc1cnc2[nH]ccc2n1.O=C1CCC(=O)N1I>>CC(C)Nc1cnc2[nH]cc(I)c2n1,,CN(C)C=O,,,,val
US20120295884A1,CCN(CC)c1cc(Cl)c(F)c(CNC(=O)OC(C)(C)C)c1>>CCN(CC)c1cc(Cl)c(F)c(CN)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US03932617,Cc1cc(=O)nc(N)[nH]1.O=C1CCC(=O)N1I>>Cc1nc(N)nc(O)c1I,,CC(=O)O,,,,val
US20160024068A1,COC(=O)c1ccc(CCCN2[C@@H](/C=C/C(=O)Cc3cccc(C(F)(F)F)c3)CCS2(=O)=O)s1>>COC(=O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(C(F)(F)F)c3)CCS2(=O)=O)s1,,CO,,[BH4-].[Na+],,val
US20030036651A1,CCOC(=O)CCCCc1cccnc1.O=Cc1cccnc1Nc1cccc([N+](=O)[O-])c1>>O=c1c(CCCc2cccnc2)cc2cccnc2n1-c1cccc([N+](=O)[O-])c1,,CCO,CN(C)C=O,CC(C)[N-]C(C)C.[Li+],,val
US20100286118A1,CC(C)(C)OC(=O)NC1(C(=O)N[C@@H](Cc2ccc(I)cc2)C(N)=O)CCOCC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(C)(C)OC(=O)NC1(C(=O)N[C@@H](Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)C(N)=O)CCOCC1,,CC#N,O,CC(=O)[O-].[K+],,val
US04324786,C1COCCO1.COC(=O)Cl.OC1=Nc2ncccc2NN1>>COC(=O)OC1=Nc2ncccc2N(C(=O)OC)N1.Cl,,C1COCCO1,,,,val
US20100273764A1,COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cccnc3Nc3ccc(NC(=O)OC(C)(C)C)nc3)n2)cc1>>COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cccnc3Nc3ccc(N)nc3)n2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040181064A1,COC(=O)[C@@H]1[C@H](O[Si](C)(C)C(C)(C)C)CCCN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCC[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H]1CO,,C1CCOC1,,,,val
US20030186969A1,COC(=O)c1ccc(CNCC(=O)OCCC(=O)c2ccc(Cl)cc2)c(N)c1.O=Cc1ccc(C(=O)N2CCCC2)cc1>>COC(=O)c1ccc(CNCC(=O)OCCC(=O)c2ccc(Cl)cc2)c(NCc2ccc(C(=O)N3CCCC3)cc2)c1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120214803A1,CCc1ccc2cccnc2c1[N+](=O)[O-]>>CCc1ccc2cccnc2c1N,Cl,,,Cl[Sn]Cl,,val
US20070032497A1,CCOC(=O)c1ccc2c(c1)nc(-c1ccc(N)cc1)n2C1CCCC1.O=C(Cl)c1ccccc1>>CCOC(=O)c1ccc2c(c1)nc(-c1ccc(NC(=O)c3ccccc3)cc1)n2C1CCCC1,,ClC(Cl)Cl,c1ccncc1,,,val
US06121253,COC(=O)c1ccc(CC(P(=O)(OCc2ccccc2)OCc2ccccc2)P(=O)(OCc2ccccc2)OCc2ccccc2)cc1>>O=C(O)c1ccc(CC(P(=O)(OCc2ccccc2)OCc2ccccc2)P(=O)(OCc2ccccc2)OCc2ccccc2)cc1,,C1COCCO1,O,Cl,[Li+].[OH-],val
US04642308,COc1ccc2ccc(N)nc2n1.O=C(O)c1ccco1>>COc1ccc2ccc(NC(=O)c3ccco3)nc2n1,,O,,CCO,,val
US04507498,CCCc1c(O)c(C(C)=O)cc(Cl)c1OCCCCCOc1c(C(C)=O)ccc(OCC(=O)OCC)c1CCC>>CCCc1c(O)c(C(C)=O)cc(Cl)c1OCCCCCOc1c(C(C)=O)ccc(OCC(=O)O)c1CCC,,CO,,[Na+].[OH-],,val
US20130053407A1,CCOC(=O)c1c(NC(=O)NC(C)C(=O)OC)cc(Cl)n1-c1ccc(-c2cccc(OC)c2O)cc1>>COc1cccc(-c2ccc(-n3c(Cl)cc4[nH]c(=O)n(C(C)C(=O)O)c(=O)c43)cc2)c1O,,CCO,,[Na],,val
US20110059954A1,COc1ccc2c(c1)CCN(C1CCNCC1)C(=O)N2.Cc1cc(C(=O)c2cc(Cl)ncn2)cc2oc(=O)n(C)c12>>COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)c4cc(C)c5c(c4)oc(=O)n5C)ncn3)CC1)C(=O)N2,,CN(C)C=O,CO,CCN(C(C)C)C(C)C,,val
US20130053409A1,C=CC(=O)Cl.COc1cc(N2CC(N(C)C)C2)c(N)cc1Nc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1>>C=CC(=O)Nc1cc(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)c(OC)cc1N1CC(N(C)C)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04518774,CCOC(=O)C(=NOC)C(C)=O.OCCO>>CCOC(=O)C(=NOC)C1(C)OCCO1,Cc1ccc(S(=O)(=O)O)cc1,c1ccccc1,,,,val
US20120052757A1,CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C.COc1cc(/C=C/C(=O)O)ccc1OC(C)=O>>COc1cc(/C=C/C(=O)O[C@H]2CC[C@@]3(C)C(=CC[C@H]4[C@@H]5CC[C@H]([C@H](C)CCCC(C)C)[C@@]5(C)CC[C@@H]43)C2)ccc1OC(C)=O,CN(C)c1ccncc1,C1CCOC1,ClCCl,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20020072586A1,CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)O.[N-]=[N+]=C(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)OC(c1ccccc1)c1ccccc1,,CCOC(C)=O,,,,val
US20050004114A1,C[Si](C)(C)CCOC(=O)CCC(=O)c1cn(-c2nc(N3CCCCC3)nc(N3CCc4ccccc43)n2)c2ccc(Cl)cc12>>O=C(O)CCC(=O)c1cn(-c2nc(N3CCCCC3)nc(N3CCc4ccccc43)n2)c2ccc(Cl)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070213336A1,CCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)OC)cc2OCCCC)c1>>CCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)O)cc2OCCCC)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20140080825A1,BrBr.O=CCCc1c(F)cccc1Cl>>O=CC(Br)Cc1c(F)cccc1Cl,,ClCCl,,,,val
US20070112016A1,BrCC1CCCCC1.CC(C)(C)OC(=O)N1CCC(C(=O)Nc2ccccc2Br)CC1>>CC(C)(C)OC(=O)N1CCC(C(=O)N(CC2CCCCC2)c2ccccc2Br)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20110124637A1,CC(C)(C)OC(=O)Nc1ccc(CO)cn1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)Nc1ccc(COS(C)(=O)=O)cn1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US04847256,CCCC(=O)CC(=O)CCC.Cc1n[nH]c(N)c1C#N>>CCCc1cc(CCC)n2nc(C)c(C#N)c2n1,,CC(=O)O,,,,val
US20120190124A1,O=C1C=C(Br)C(=O)N1.SCCS>>O=C1CC2(SCCS2)C(=O)N1,,CO,,CC(=O)[O-].[Na+],,val
US05500435,Cn1cnc2cc(C(O)c3ccccc3)ccc21>>Cn1cnc2ccccc21,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20100113511A1,CCCCc1ccc(C#CCCBr)cc1.Cc1cncc(C)c1>>CCCCc1ccc(C#CCC[n+]2cc(C)cc(C)c2)cc1.[Br-],,CC#N,,,,val
US20120129872A1,COc1ccc(S(N)(=O)=O)cc1N=C=S.N>>COc1ccc(S(N)(=O)=O)cc1NC(N)=S,,CO,,C1COCCO1,,val
US20100152208A1,CCOC(=O)CSc1nc2nc(N3CCC(Oc4cc(F)ccc4Br)CC3)sc2c(=O)[nH]1>>O=C(O)CSc1nc2nc(N3CCC(Oc4cc(F)ccc4Br)CC3)sc2c(=O)[nH]1,,CO,,[Li+].[OH-],,val
US20070015784A1,CSCC[C@@H]1NC2(CCN(C(=O)OC(C)(C)C)CC2)N(Cc2ccccc2)C1=O>>CSCC[C@@H]1NC2(CCNCC2)N(Cc2ccccc2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20040198982A1,COC(=O)C1(Br)CCCCC1.Sc1ccccc1Br>>COC(=O)C1(Sc2ccccc2Br)CCCCC1,,CO,,CCN(C(C)C)C(C)C,,val
US06083990,CC/C(=C(\c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1.CI>>CC/C(=C(\c1ccccc1)c1ccc(OCC[N+](C)(C)C)cc1)c1ccccc1.[I-],,CCOC(C)=O,,,,val
US20110275611A1,COc1cccc(C(=O)CN=[N+]=[N-])c1.Cl>>COc1cccc(C(=O)CN)c1.Cl,[Pd],CO,,,,val
US20130296298A1,CCOC(=O)C(CC)Oc1ccc2nnc(-c3cccs3)n2n1>>CCC(Oc1ccc2nnc(-c3cccs3)n2n1)C(=O)O,,C1COCCO1,,[Na+].[OH-],,val
US20070197512A1,CC(C)c1cccc(NC(=O)C(C)(C)Br)c1O>>CC(C)c1cccc2c1OC(C)(C)C(=O)N2,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US04675324,CCC(=O)N1Cc2cn[nH]c2-c2cc(OCC(=O)OC)ccc21>>CCC(=O)N1Cc2cn[nH]c2-c2cc(OCC(=O)O)ccc21,,CO,O,[Na+].[OH-],,val
US20160222022A1,COC(=O)c1ccc2c(c1)OC[C@H](c1ccccc1C)NC2.O=C(O)C1CCOCC1>>COC(=O)c1ccc2c(c1)OC[C@H](c1ccccc1C)N(C(=O)C1CCOCC1)C2,,ClCCl,,CCN(CC)CC,Cl,val
US20110196002A1,COC(=O)C(NC(=O)c1cc(-c2ccc(O)cc2)no1)C(C)C.Fc1ccc(CBr)cc1>>COC(=O)C(NC(=O)c1cc(-c2ccc(OCc3ccc(F)cc3)cc2)no1)C(C)C,,O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20080280875A1,CCOC(=O)c1cc(OC2CN(C(c3ccccc3)c3ccccc3)C2)c2cc(C)oc2c1>>CCOC(=O)c1cc(OC2CNC2)c2cc(C)oc2c1,[Pd],CCOC(C)=O,CO,,,val
US20110306607A1,C1CC2OC2C1.COC(=O)c1ccc(O)c(OC)c1>>COC(=O)c1ccc(O[C@@H]2CCC[C@H]2O)c(OC)c1,,CCOC(C)=O,c1ccccc1,CCOCC,FB(F)F,val
US06407116B1,BrCCCCBr.COc1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1>>COc1ccc(Cn2c(=O)c3ccccc3n(CCCCBr)c2=O)cc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20040171097A1,NC(=S)Nc1ccc(C(=O)O)cc1>>NC(=S)Nc1ccccc1,,CN(C)C=O,,CC(C)N=C=NC(C)C,,val
US20060199800A1,CC#CCO.CCC1CCCCCN1c1ncnc(Cl)c1F>>CC#CCOc1ncnc(N2CCCCCC2CC)c1F,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US05136868,CC(=O)OC(C)=O.Cc1cccc(N)c1>>CC(=O)Nc1cccc(C)c1,,O,,,,val
US20160176854A1,CN(C(=O)n1cnc(-c2cccc([N+](=O)[O-])c2)c1)C1CCOCC1>>CN(C(=O)n1cnc(-c2cccc(N)c2)c1)C1CCOCC1,[Pd],CCOC(C)=O,,CCO,,val
US04940710,Cl.O=C(O)c1cn(C2CC2)c2cc(N3CCNC(c4ccsc4)C3)c(F)cc2c1=O>>Cl.O=C(O)c1cn(C2CC2)c2cc(N3CCNC(c4ccsc4)C3)c(F)cc2c1=O,,[Na+],[OH-],,,val
US20020082218A1,CC(=O)Cl.CCOC(=O)C(Cc1ccc(C2CCCNC2)cc1)NC(=O)C1(NC(=O)OC(C)(C)C)CCCC1>>CCOC(=O)C(Cc1ccc(C2CCCN(C(C)=O)C2)cc1)NC(=O)C1(NC(=O)OC(C)(C)C)CCCC1,,ClCCl,,CCN(CC)CC,,val
US20050143588A1,COc1ccc([C@@H]2COc3c(ccc(OC(C)=O)c3C)[C@H]2O)cc1>>COc1ccc([C@@H]2COc3c(ccc(O)c3C)[C@H]2O)cc1,,CCO,,c1c[nH]cn1,,val
US20140094453A1,CC(C)(C)OC(=O)N1CCCC[C@@H]1COc1cccc([N+](=O)[O-])c1C#N>>CC(C)(C)OC(=O)N1CCCC[C@@H]1COc1cccc(N)c1C#N,[Pd],CCOC(C)=O,,,,val
US20040171777A1,C=C(C)c1ccc(Cl)cc1.S=C(S)c1ccccc1>>CC(C)(SC(=S)c1ccccc1)c1ccc(Cl)cc1,,CCCCCC,,,,val
US20120231462A1,CN(C)S(=O)(=O)n1ccnc1-c1ccnc2c1ccn2[C@H]1C[C@H](O)[C@@H](CO)O1>>OC[C@H]1O[C@@H](n2ccc3c(-c4ncc[nH]4)ccnc32)C[C@@H]1O,,CC(=O)O,,,,val
US20040106808A1,C/C=C(\C)C(=O)Cl.CCCc1cc(=O)oc2cc(O)cc(O)c12>>CC=C(C)C(=O)Oc1cc(O)c2c(CCC)cc(=O)oc2c1,,ClCCCl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20040186160A1,O=C1Cc2cc(F)ccc2N1.O=Cc1[nH]c2c(c1CCCN1CCOCC1)CCCCC2>>O=C1Nc2ccc(F)cc2/C1=C/c1[nH]c2c(c1CCCN1CCOCC1)CCCCC2,,CCO,,C1CCNCC1,,val
US20150218183A1,CC(=O)O[C@@H]1CCCC[C@H]1c1ccccc1.O=C1CCC(=O)N1I>>CC(=O)O[C@@H]1CCCC[C@H]1c1ccc(I)cc1,,O=C(O)C(F)(F)F,,,,val
US20070142365A1,NC(=NO)c1ncc2cccnc2c1O.O=C(Cl)Cc1ccc(F)cc1>>Cl.Oc1c(-c2noc(Cc3ccc(F)cc3)n2)ncc2cccnc12,,C1COCCO1,,,,val
US05091432,CCOC(=O)CCn1cnc2c(=O)[nH]cnc21.NCCc1ccc(S(N)(=O)=O)cc1>>NS(=O)(=O)c1ccc(CCNC(=O)CCn2cnc3c(=O)[nH]cnc32)cc1,,CC#N,,,,val
US20100016279A1,N#CC1CCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1.NO>>N=C(NO)C1CCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1,,CCO,,,,val
US20100016337A1,CCOC(=O)CCc1ccc(-c2ccccc2F)nc1>>O=C(O)CCc1ccc(-c2ccccc2F)nc1,,CCO,,[Na+].[OH-],,val
US20150284358A1,C#Cc1nc(-c2cncc(Cl)c2)n(Cc2cc(Cl)ccc2Cl)c1C(=O)OC>>C#Cc1nc(-c2cncc(Cl)c2)n(Cc2cc(Cl)ccc2Cl)c1C(=O)O,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20080021022A1,COc1cccc(-c2oncc2C(=O)O)c1.c1ccc(C2CCNC2)cc1>>COc1cccc(-c2oncc2C(=O)N2CCC(c3ccccc3)C2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20160016903A1,C=CC(=O)OC.CN(C)C1(c2ccccc2)CCC2(CCNC2)CC1>>COC(=O)CCN1CCC2(CCC(c3ccccc3)(N(C)C)CC2)C1,,C1CCOC1,,,,val
US07109229B2,CN(C)Cc1c[nH]c2cc(C(F)(F)F)ccc12.[C-]#N>>N#CCc1c[nH]c2cc(C(F)(F)F)ccc12,,CCOC(C)=O,,CN(C)C=O,,val
US20070054884A1,N#Cc1cc(Oc2ccc(Cl)cc2Cl)c(OCc2ccccc2)cc1Cl>>N#Cc1cc(Oc2ccc(Cl)cc2Cl)c(O)cc1Cl,,ClCCl,,BrB(Br)Br,,val
US20060148862A1,COC(=O)[C@H](Cc1ccc(O)cc1)Nc1ccccc1C(=O)c1ccccc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)[C@H](Cc1ccc(OS(=O)(=O)C(F)(F)F)cc1)Nc1ccccc1C(=O)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,[Cl-].[NH4+],val
US04572909,CCOC(=O)CC(=O)CCl.CN(CCO)Cc1ccccc1>>CCOC(=O)CC(=O)COCCN(C)Cc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20040082619A1,CCCCI.COc1cc(C)c(C)[nH]c1=O>>CCCCn1c(C)c(C)cc(OC)c1=O,,CCCCO,,[K+].[OH-],,val
US20140206680A1,CC(=O)c1sccc1Br.NN=C(c1ccccc1)c1ccccc1>>C/C(=N\N=C(c1ccccc1)c1ccccc1)c1sccc1Br,,CCO,,,,val
US20040167129A1,COC(=O)c1c(C)c(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(CC2CCCCC2)c1C.NC1CCCCC1>>Cc1c(C(=O)NC2CCCCC2)c(C)n(CC2CCCCC2)c1-c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,Cc1ccccc1,,C[Al](C)C,,val
US20150368265A1,CI.CNC(=O)c1c(-c2cc[nH]c(=O)c2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc4c(n3)-c3cc5c(F)cccc5n3CO4)cc12>>CNC(=O)c1c(-c2ccn(C)c(=O)c2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc4c(n3)-c3cc5c(F)cccc5n3CO4)cc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160244438A1,CCOC(=O)C1=C(CBr)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br.O=C(O)[C@@H]1COCCN1>>CCOC(=O)C1=C(CN2CCOC[C@H]2C(=O)O)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20150361100A1,OCc1cc2ccccn2c1-c1ccncc1>>O=Cc1cc2ccccn2c1-c1ccncc1,O=[Mn]=O,,,,,val
US05998433,CN(C)Cc1cc2c(o1)CCN(S(=O)(=O)c1ccc(/C=C\c3cccc(Cl)c3)cc1)C2.Cl>>CN(C)Cc1cc2c(o1)CCN(S(=O)(=O)c1ccc(/C=C\c3cccc(Cl)c3)cc1)C2.Cl,,CO,,,,val
US20080221201A1,CC(C)N.O=S(=O)(Cl)c1ccc(Br)cc1C(F)(F)F>>CC(C)NS(=O)(=O)c1ccc(Br)cc1C(F)(F)F,,ClCCl,,,,val
US20140171403A1,CC1CC(CN)CCN1C(=O)OC(C)(C)C>>CC1CC(CN)CCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040019065A1,CI.O=C(OCc1ccccc1)N1C[C@@H](O)[C@H](O)C1>>CO[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1O,,C1CCOC1,,[H-].[Na+],,val
US20160194328A1,BrCCCBr.Nc1ncnc2[nH]c(Sc3cc(Cl)cc(Cl)c3)nc12>>Nc1ncnc2c1nc(Sc1cc(Cl)cc(Cl)c1)n2CCCBr,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100004271A1,COC(=O)CCc1cc(Br)c(Oc2ccc([N+](=O)[O-])cc2)c(Br)c1>>COC(=O)CCc1cc(Br)c(Oc2ccc(N)cc2)c(Br)c1,[Fe],CC(=O)O,O,,,val
US20110118283A1,CC(C)(C)CC1NC(C(=O)OC(C)(C)C)C(c2cccc(Cl)c2)C1(C#N)c1cc(Br)cs1.O=C(O)C(F)(F)F>>CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2)C1(C#N)c1cc(Br)cs1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20080153850A1,COC(=O)[C@H](C)Oc1ccccc1-c1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1>>C[C@H](Oc1ccccc1-c1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1)C(=O)O,,O,,Cl,,val
US04410518,CCOP(=S)(NC1CCCC1)OCC.CNC(=O)ON=C(SC)C(=O)N(C)C.O=S(Cl)Cl>>CCOP(=S)(OCC)N(C1CCCC1)S(=O)CNC(=O)ON=C(SC)C(=O)N(C)C,,c1ccncc1,,,,val
US20040092572A1,CC(Br)Br.COc1ccc2c(Cc3ccc(O)cc3)c(-c3ccc(Cl)cc3)c(=O)oc2c1>>COc1ccc2c(Cc3ccc(OCCBr)cc3)c(-c3ccc(Cl)cc3)c(=O)oc2c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080221107A1,CC1(O)CCN(c2ccc([N+](=O)[O-])nc2)C1>>CC1(O)CCN(c2ccc(N)nc2)C1,[Pd],CCO,,,,val
US20080139534A1,N=C(NO)c1ccc(NC(=O)CCCC(=O)Nc2ccc(C(=N)NO)cc2)cc1.O=C(OC(=O)c1ccccc1)c1ccccc1>>O=C(CCCC(=O)Nc1ccc(-c2noc(-c3ccccc3)n2)cc1)Nc1ccc(-c2noc(-c3ccccc3)n2)cc1,,CS(C)=O,,O=C([O-])O.[Na+],,val
US20120238559A1,Cc1cn(C)nc1C(=O)Nc1cc([Sn](C)(C)C)cc2c1cnn2S(=O)(=O)c1ccccc1.N#Cc1cc(Br)c2ccn(S(=O)(=O)c3ccc([N+](=O)[O-])cc3)c2c1>>Cc1cn(C)nc1C(=O)Nc1cc(-c2cc(C#N)cc3[nH]ccc23)cc2[nH]ncc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20040229949A1,CCOC(=O)C(OCC)=C(C)c1ccc(OCc2ccccc2)cc1>>CCOC(=O)C(OCC)C(C)c1ccc(O)cc1,[Pd],CCOC(C)=O,,,,val
US20010046993A1,O=C(NCCCN1CCN(Cc2ccccc2)CC1)OCCCl>>O=C1OCCN1CCCN1CCN(Cc2ccccc2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US04367238,COc1c(C)cccc1Oc1cccc(Cl)c1.O=C1CCC(=O)N1Br>>COc1c(CBr)cccc1Oc1cccc(Cl)c1,,c1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20130102776A1,CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2OCC3=O)CC1.CCCO>>CCCOc1ccc2c(c1CN1CCN(C(=O)OC(C)(C)C)CC1)OCC2=O,,Cc1ccccc1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110201625A1,CC(C)COc1ccc(N)cc1.O=C=NCCCl>>CC(C)COc1ccc(NC(=O)NCCCl)cc1,,CCOCC,,,,val
US04133809,CN(C)CCBr.Cc1nnc2n1-c1ccc(Cl)cc1N(c1ccccc1)C(=O)C2>>Cc1nnc2n1-c1ccc(Cl)cc1N(c1ccccc1)C(=O)C2CCN(C)C,,COCCOC,,[H-].[Na+],,val
US20030096826A1,O=[N+]([O-])c1ccc(Br)c(OCc2ccccc2)c1.SCc1ccccc1>>O=[N+]([O-])c1ccc(SCc2ccccc2)c(OCc2ccccc2)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20140336108A1,Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCNC(=O)OC(C)(C)C)sc34)cc2F)c1>>Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCN)sc34)cc2F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06277987B1,CC(C)(C)OC(=O)CN=C(c1ccccc1)c1ccccc1.Cn1c(=O)n(CCCCI)c(=O)c2ccccc21>>Cn1c(=O)n(CCCCC(N=C(c2ccccc2)c2ccccc2)C(=O)OC(C)(C)C)c(=O)c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20040248947A1,CC#C[Sn](CCCC)(CCCC)CCCC.COc1ccc(CNc2ccccc2C(=O)Nc2ccc(Br)c(C(F)(F)F)c2)cn1>>CC#Cc1ccc(NC(=O)c2ccccc2NCc2ccc(OC)nc2)cc1C(F)(F)F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,[Na+].[OH-],,val
US20040229858A1,COC(=O)c1ccc(OC[C@@H]2CC[C@@H](C)N2C(=O)OC(C)(C)C)cc1>>COC(=O)c1ccc(OC[C@@H]2CC[C@@H](C)N2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04147793,CC(Cl)c1ccccc1.O=C(Cn1cncn1)c1ccc(Cl)cc1>>CC(c1ccccc1)C(C(=O)c1ccc(Cl)cc1)n1cncn1,,CN(C)C=O,,O,[H-].[Na+],val
US20150225397A1,CC1c2oncc2CC2(Cc3ccccc3)c3nn(C)cc3CCC12>>CC1C(=O)C(C#N)CC2(Cc3ccccc3)c3nn(C)cc3CCC12,,C1CCOC1,CO,C[O-].[Na+],,val
US20040058970A1,CCCC[Sn](CCCC)(CCCC)c1cccnc1.Cc1onc(-c2ccccc2)c1-c1nnc2n1Cc1ccc(Br)cc1-2>>Cc1onc(-c2ccccc2)c1-c1nnc2n1Cc1ccc(-c3cccnc3)cc1-2,,CN(C)C=O,,,,val
US05656642,NCCc1ccc(Cl)cc1.O=C1CCN(C(=O)c2ccc(-n3cncn3)cc2)CC1>>O=C(c1ccc(-n2cncn2)cc1)N1CCC(NCCc2ccc(Cl)cc2)CC1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20030105151A1,Cc1c(CCC(=O)O)c[nH]c1C=O.Cc1cccc2c1CC(=O)N2>>Cc1cccc2c1C(=Cc1[nH]cc(CCC(=O)O)c1C)C(=O)N2,,CCO,,C1CCNCC1,,val
US20160046635A1,CCNCC.CCNc1nc(NCC2CC2)c2nc(Cl)nc(NCC3CC3)c2n1>>CCNc1nc(NCC2CC2)c2nc(N(CC)CC)nc(NCC3CC3)c2n1,,CCCCO,,,,val
US08222453B2,CCOC(=O)[C@@H]1CCN(C(=O)OC(C)(C)C)[C@H]1c1cc([N+](=O)[O-])ccc1S(=O)(=O)CC>>CCOC(=O)[C@@H]1CCN(C(=O)OC(C)(C)C)[C@H]1c1cc(N)ccc1S(=O)(=O)CC,[Pd],C1CCOC1,CO,[H][H],,val
US05306562,CCOC(=O)CCCCOc1ccc2oc3ccccc3c(=O)c2c1>>O=C(O)CCCCOc1ccc2oc3ccccc3c(=O)c2c1,,CCO,,Cl,[Na+].[OH-],val
US20060148823A1,CCN(CC)C(=O)c1ccc2c(c1)Oc1c(OC)cccc1N2C1CCN(Cc2ccccc2)CC1>>CCN(CC)C(=O)c1ccc2c(c1)Oc1c(O)cccc1N2C1CCN(Cc2ccccc2)CC1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US05801008,CSC(SC)=C(C#N)C#N.NNc1ccccc1>>CSc1nn(-c2ccccc2)c(N)c1C#N,,CCO,,,,val
US20150133451A1,CI.Cn1ccc(N2CCCC2=O)n1>>CC1CCN(c2ccn(C)n2)C1=O,,C1CCOC1,,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20070043080A1,CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.O=Cc1cccc2[nH]ccc12>>CC(C)C(=O)Nc1cccc(C2CCN(Cc3cccc4[nH]ccc34)CC2)c1,,CC(=O)O,,,,val
US20060276533A1,COC(=O)c1sc(C2(O)CCCCC2)cc1NC(=O)OC(C)(C)C>>COC(=O)c1sc(C2=CCCCC2)cc1N,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150329523A1,COCCOCCOCCBr.N#Cc1cc(O)cc([N+](=O)[O-])c1>>COCCOCCOCCOc1cc(C#N)cc([N+](=O)[O-])c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100004459A1,CCOC(=O)c1c(C)ccnc1-c1ccc(OCOC)c(C#N)c1.Cl>>CCOC(=O)c1c(C)ccnc1-c1ccc(O)c(C#N)c1.Cl,,ClCCl,,C1COCCO1,,val
US04994493,BrCCCc1ccccc1.COC(=O)c1ccccc1N>>COC(=O)c1ccccc1NCCCc1ccccc1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20050049203A1,COc1ccc(C(=O)c2c(C)cc(OC)nc2O)cc1>>COc1ccc(Cc2c(C)cc(OC)[nH]c2=O)cc1,,C1CCOC1,,[BH3-]C#N.[Na+],,val
US20150232452A1,CCn1cc(-c2cccc(N)c2)c(-c2ccncc2)n1.O=C=Nc1cccc(C(F)(F)F)c1>>CCn1cc(-c2cccc(NC(=O)Nc3cccc(C(F)(F)F)c3)c2)c(-c2ccncc2)n1,,ClCCl,,,,val
US05585394,CCN(C#N)CC.CCO.CCOc1ccc2c(c1)n(C13CC4CC(CC(C4)C1)C3)c(=O)n2S(=O)(=O)c1ccc(N)cc1OC.Cl>>CCOc1ccc2c(c1)n(C13CC4CC(CC(C4)C1)C3)c(=O)n2S(=O)(=O)c1ccc(NC(=N)N(CC)CC)cc1OC.Cl.O,,CCO,,CCOC(C)=O,,val
US20100009991A1,COC(=O)[C@@H](C)Cl.OCCCc1cc(O)ccc1F>>COC(=O)[C@H](C)Oc1ccc(F)c(CCCO)c1,,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050215495A1,COC(CBr)OC.c1ccc(-c2c[nH]cn2)cc1>>COC(Cn1cnc(-c2ccccc2)c1)OC,,CN(C)C=O,,[H-].[Na+],,val
US20040152743A1,COc1nn(-c2ccc(N)c(OC)c2)c(=O)o1.O=C=NC(=O)c1ccc(F)cc1Cl>>COc1nn(-c2ccc(NC(=O)NC(=O)c3ccc(F)cc3Cl)c(OC)c2)c(=O)o1,,CC#N,,CCN(CC)CC,Cl,val
US05629406,CC(C)(C)NC(=O)[C@@H]1[C@H](O[Si](C)(C)C(C)(C)C)CCN1C(=O)OC(C)(C)C.NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)C(=O)O>>CC(C)(C)NC(=O)[C@@H]1[C@H](O)CCN1C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1,,C1COCCO1,CO,Cl,,val
US20040143115A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=c1ccc(Br)c[nH]1>>O=S(=O)(Oc1ccc(Br)cn1)C(F)(F)F,,ClCCl,c1ccncc1,,,val
US05919777,O=C1NCCN(Cc2ccccc2)[C@@H]1Cc1ccccc1>>c1ccc(C[C@@H]2CNCCN2Cc2ccccc2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04511392,NNC(=O)c1ccccc1[N+](=O)[O-].S=C=S>>O=[N+]([O-])c1ccccc1-c1nnc(S)o1,,c1ccncc1,,Cl,O,val
US20160130267A1,O=[N+]([O-])c1ccc(F)c([C@@]2(C(F)F)NC(=S)CCC2(F)F)c1>>Nc1ccc(F)c([C@@]2(C(F)F)NC(=S)CCC2(F)F)c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US05334741,CC(C)[C@H]1CC[C@H](C)C[C@@H]1O.O=P(Cl)(Cl)Cl>>CC1CCC(C(C)C)C(OP(=O)(Cl)Cl)C1,,Cc1ccccc1,,CCN(CC)CC,,val
US20160229810A1,C#CCOc1ccc(-c2nc3ccc(C=O)cc3[nH]2)cc1.CN1CCN(c2ccc([N+](=O)[O-])c(N)c2)CC1>>C#CCOc1ccc(-c2nc3ccc(-c4nc5ccc(N6CCN(C)CC6)cc5[nH]4)cc3[nH]2)cc1,[Pd],CCO,O,,,val
US20160052850A1,Cc1c(C)c2c(c(C)c1OC(=O)CCC(=O)OCCO)CCC(C)(CCCC(C)CCCC(C)CCCC(C)C)O2.Cn1c(=O)c2c(ncn2C)n(C)c1=O>>Cc1c(C)c2c(c(C)c1OC(=O)CCC(=O)OCCO)CCC(C)(CCCC(C)CCCC(C)CCCC(C)C)O2.Cn1c(=O)c2c(ncn2C)n(C)c1=O,,O,,CCO,,val
US20070032485A1,CCOC(=O)C1CCN(c2cnc(N[C@H]3C[C@@H](CC)N(C(=O)OCC)c4ccc(OC)nc43)nc2Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1>>CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(N3CCC(C(=O)O)CC3)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC,,CCO,CCOC(C)=O,Cl,[K+].[OH-],val
US05807899,CCC(C(=O)c1ccc(OCc2ccccc2)cc1)c1ccccc1.Ic1ccc(I)cc1>>CCC(c1ccccc1)C(O)(c1ccc(I)cc1)c1ccc(OCc2ccccc2)cc1,,C1CCOC1,CCOCC,[Li]CCCC,[Cl-].[NH4+],val
US20010046975A1,CCNC(=O)c1c([Si](C)(C)C)ccc(I)c1Cl.OB(O)c1ccccc1>>CCNC(=O)c1c([Si](C)(C)C)ccc(-c2ccccc2)c1Cl,,Cc1ccccc1,ClCCl,O=C([O-])[O-].[Na+].[Na+],,val
US20040132727A1,COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.NCCN1CCCC1.S=C(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=S)NCCN4CCCC4)cc3)c2cc1OC,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20090082352A1,CCN(CC1CCCC1)c1ccc(C(F)(F)F)cc1C=O.CSCCOc1cnc(N)nc1>>CCN(CC1CCCC1)c1ccc(C(F)(F)F)cc1CNc1ncc(OCCSC)cn1,,Cc1ccccc1,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20030207899A1,COCCOC(=O)N[C@H]1CCN(c2ccc(N3C[C@H](CN(C(=O)OCC(Cl)(Cl)Cl)c4ccon4)OC3=O)cc2F)C1>>COCCOC(=O)N[C@H]1CCN(c2ccc(N3C[C@H](CNc4ccon4)OC3=O)cc2F)C1,[Zn],CC(=O)O,O,,,val
US20150197498A1,COc1cc(-c2ccc(-c3nc4cc([N+](=O)[O-])ccc4o3)cc2)cc(OC)c1OC>>COc1cc(-c2ccc(-c3nc4cc(N)ccc4o3)cc2)cc(OC)c1OC,[Pd],CO,,CCOC(C)=O,,val
US20160102083A1,COC(=O)c1csc([N+](=O)[O-])c1C>>COC(=O)c1csc(N)c1C,[Pd],CCOC(C)=O,,CC[SiH](CC)CC,,val
US20050192208A2,Cl.Clc1cccc(Cl)c1CO[C@H]1CCCC[C@@H]1N1CCOCC1>>Cl.O=C1CCN([C@H]2CCCC[C@@H]2OCc2c(Cl)cccc2Cl)C1,,CCOCC,,,,val
US05336690,O=C=NS(=O)(=O)Cl.Oc1c(-c2ccccc2)cccc1-c1ccccc1>>O=C(NS(=O)(=O)Cl)Oc1c(-c2ccccc2)cccc1-c1ccccc1,,CCCCCC,CCOCC,,,val
US05610293,Cc1ccc(S(=O)(=O)N2CCN(S(=O)(=O)c3ccc(C)cc3)CC(=O)NCC(C3CCCCC3)NC(=O)CN(S(=O)(=O)c3ccc(C)cc3)CC2)cc1>>C1CCC(C2CNCCNCCNCCNCCN2)CC1,,COCCOC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040266839A1,COc1ccc([N+](=O)[O-])cc1CNC(C)=O>>COc1ccc(N)cc1CNC(C)=O,[Pd],CCO,,[H][H],,val
US20120302541A1,COc1ccc(Oc2cc(C(=N)NO)ccc2NC[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1.O=C(n1ccnc1)n1ccnc1>>COc1ccc(Oc2cc(-c3noc(=O)[nH]3)ccc2NC[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20110137040A1,CN=C=S.Clc1ccc(C2=NNCC2c2ccccc2)cc1>>CNC(=S)N1CC(c2ccccc2)C(c2ccc(Cl)cc2)=N1,,CCO,,,,val
US20120165556A1,Brc1ccc(-c2ccc3c(-c4ccccc4)c4ccccc4c(-c4ccccc4)c3c2)cc1.OB(O)c1cc2ccccc2c2c1oc1ccccc12>>c1ccc(-c2c3ccccc3c(-c3ccccc3)c3cc(-c4ccc(-c5cc6ccccc6c6c5oc5ccccc56)cc4)ccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20160207922A1,CC(C)(C)OC(=O)N1CCC2(CCNC2)CC1.Cc1c([C@@H]2CO2)ccc2c1COC2=O>>Cc1c([C@@H](O)CN2CCC3(CCN(C(=O)OC(C)(C)C)CC3)C2)ccc2c1COC2=O,,CCO,,,,val
US06184225B2,COC(=O)Oc1ccc(F)cc1F.O=[N+]([O-])O>>COC(=O)Oc1cc([N+](=O)[O-])c(F)cc1F,,O=S(=O)(O)O,,,,val
US20080249165A1,CC(=O)O.O.O[C@@H]1[C@@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)O[C@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@H]1O>>O=C(O[C@@H]1[C@@H](CO)O[C@H](CO)[C@H]1OC(=O)c1ccccc1)c1ccccc1,,CC(=O)O,,,,val
US20030229058A1,COc1ccc([N+](=O)[O-])cc1-c1cccc(Cl)c1>>COc1ccc(N)cc1-c1cccc(Cl)c1,O=[Pt]=O,C1CCOC1,CO,[H][H],,val
US20130210801A1,CC(C)(C)[Si](C)(C)Cl.Cc1cc2[nH]c(=O)ccc2c(-c2ccc(Cl)cc2)c1[C@@H](CO)OC(C)(C)C>>Cc1cc2[nH]c(=O)ccc2c(-c2ccc(Cl)cc2)c1[C@@H](CO[Si](C)(C)C(C)(C)C)OC(C)(C)C,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20110237589A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.Fc1ccc(Br)nc1>>CC(=O)c1ccc(F)cn1,[Cu]I,CC#N,,Cl,O=C([O-])O.[Na+],val
US20140256729A1,COc1ccc(N)cc1Br.CS(=O)(=O)Cl>>COc1ccc(NS(C)(=O)=O)cc1Br,,c1ccncc1,,,,val
US20100081646A1,COC(=O)c1ccc(OC)c(OCC2CC2)c1NC(C)=O>>COc1ccc2c(O)cc(=O)[nH]c2c1OCC1CC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20120289501A1,OC1CC(c2ccco2)Oc2cc(Br)ccc21>>Brc1ccc2c(c1)OC(C1CCCO1)CC2,O=[Pt]=O,CC(=O)O,,[H][H],,val
US20130210844A1,Nc1cccc2c(Nc3cc(C(F)(F)F)ccc3F)ncnc12.O=C(O)c1c(F)cccc1Cl>>O=C(Nc1cccc2c(Nc3cc(C(F)(F)F)ccc3F)ncnc12)c1c(F)cccc1Cl,CN(C)C=O,ClCCl,,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US04258059,C#CCBr.NS(=O)(=O)c1cc(C(=O)NNc2ccccc2)ccc1Cl>>CC#CN(NC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1)c1ccccc1,,CN(C)C=O,,,,val
US20100216814A1,CC(=CBr)c1ccccc1Cl.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>C/C(=C/n1c2c(c3cc(C)ccc31)CN(C)CC2)c1ccccc1Cl,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US04512924,CCC(C(=O)N1C(C(=O)OC(C)(C)C)CCN1C(=O)OCc1ccccc1)N1C(=O)c2ccc(C(=O)OCc3ccccc3)cc2C1=O>>CCC(C(=O)N1NCCC1C(=O)OC(C)(C)C)N1C(=O)c2ccc(C(=O)O)cc2C1=O,[Pd],CO,,,,val
US20110190339A1,CCC(N)C1(C(F)(F)F)CCC(O)CC1.COc1nccc2cc(F)c(Cl)cc12>>CCC(N)C1(C(F)(F)F)CCC(Oc2cc3ccnc(OC)c3cc2Cl)CC1,,CC(=O)N(C)C,,[H-].[Na+],,val
US05342839,Fc1ccc(C(CCCCl)c2ccc(F)cc2)cc1.OC(COc1ccc(F)cc1)CN1CCCNCC1>>OC(COc1ccc(F)cc1)CN1CCCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,,Cc1ccccc1,,O=C([O-])[O-].[Ca+2],,val
US20140179666A1,CC(C)(C)OC(=O)N1CC(C)(CO)c2ccc(Br)cc21.CI>>COCC1(C)CN(C(=O)OC(C)(C)C)c2cc(Br)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20110166121A1,CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(N3CC[C@H](N)C3)nc2s1.CCOC(=O)Cl>>CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(N3CC[C@H](NC(=O)OCC)C3)nc2s1,,ClCCl,,CCN(CC)CC,,val
US20110098302A1,NCC(CC(=O)O)c1ccc(Cl)cc1>>O=C1CC(c2ccc(Cl)cc2)CN1,,ClCCl,,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US20100267634A1,COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2cc(CN(Cc3ccc(NC(=O)[C@H]4CCCN4C(=O)OCC4c5ccccc5-c5ccccc54)cc3)c3ccc(F)cc3)ccc2[nH]1)C(C)(C)O>>COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2cc(CN(Cc3ccc(NC(=O)[C@H]4CCCN4)cc3)c3ccc(F)cc3)ccc2[nH]1)C(C)(C)O,,CC#N,,CCNCC,,val
US07138400B2,NC1C2CCC1Cc1c(F)cccc1C2.O=S(=O)(O)Oc1ccccc1O>>O=S(=O)(NC1C2CCC1Cc1c(F)cccc1C2)Oc1ccccc1O,,C1CCOC1,CCOC(C)=O,,,val
US20140065136A1,COC(=O)C1(O)CC1.COc1c(Cl)nc(Cl)nc1Cl>>COC(=O)C1(Oc2nc(Cl)nc(Cl)c2OC)CC1,,C1CCOC1,,[H-].[Na+],,val
US20110009391A1,CC(C)(C)OC(=O)N1CCN(c2ccc(N3CCNCC3)cn2)c2ccccc21.CCS(=O)(=O)Cl>>CCS(=O)(=O)N1CCN(c2ccc(N3CCN(C(=O)OC(C)(C)C)c4ccccc43)nc2)CC1,,CCN(CC)CC,,ClCCl,,val
US20080234262A1,C[C@@H]1COCCN1.Oc1cccc(-c2nc(Br)c3cnn(-c4ccccc4)c3n2)c1>>C[C@@H]1COCCN1c1nc(-c2cccc(O)c2)nc2c1cnn2-c1ccccc1,,CCO,,,,val
US20160145212A1,COC(=O)Cc1ccc(-c2nc3ccccc3c(-c3ccccc3)c2Cl)s1.N>>NC(=O)Cc1ccc(-c2nc3ccccc3c(-c3ccccc3)c2Cl)s1,,CCOCC,CO,,,val
US20080004263A1,BrBr.CC(=O)c1c(-c2cccc(Br)c2)noc1C>>Cc1onc(-c2cccc(Br)c2)c1C(=O)CBr,,ClC(Cl)Cl,,CC(=O)O,O,val
US20100076029A1,CC(C)(CO)c1cc(NC(=O)C(C)(C)S(=O)(=O)CCC(F)(F)F)on1.COCCBr>>COCCOCC(C)(C)c1cc(NC(=O)C(C)(C)S(=O)(=O)CCC(F)(F)F)on1,,C1CCOC1,O,[H-].[Na+],,val
US20020037888A1,CC(C)(C)N=C=O.CCC1(c2cccc(OC)c2)CCCCN(CCN)C1=O>>CCC1(c2cccc(OC)c2)CCCCN(CCNC(=O)NC(C)(C)C)C1=O,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20140275061A1,CC(C)(C)OC(=O)N1CCc2c(Br)cccc2C1.CCCC[Sn](CCCC)(CCCC)c1ccncc1>>CC(C)(C)OC(=O)N1CCc2c(cccc2-c2ccncc2)C1,,Cc1ccccc1,,[Cl-].[Li+],,val
US05344843,COC(=O)C(=O)c1ccc(OCCOc2ccc3ccccc3c2)cc1.N>>NC(=O)C(=O)c1ccc(OCCOc2ccc3ccccc3c2)cc1,,C1CCOC1,CO,,,val
US20090306089A1,COc1ccc2c(n1)NC(=O)CN2.O=C(Cl)OCc1ccccc1>>COc1ccc2c(n1)NC(=O)CN2C(=O)OCc1ccccc1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20100130545A1,CC(C)C(=O)O[C@@]1(CCN(C)CCCc2nc(-c3ccccc3)c(-c3ccccc3)n2COCC[Si](C)(C)C)C[C@H]2CC[C@@H]1C=C2c1ccccc1>>CC(C)C(=O)O[C@@]1(CCN(C)CCCc2nc(-c3ccccc3)c(-c3ccccc3)[nH]2)C[C@H]2CC[C@@H]1C=C2c1ccccc1,,C1CCOC1,ClCCl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05856320,COC(=O)C(=NO)C(C)=O.FCBr>>COC(=O)C(=NOCF)C(C)=O,,CN(C)C=O,CS(C)=O,O=C([O-])[O-].[K+].[K+],,val
US04551534,COC(=O)C1=C(C)NC2=C(C(=O)CNC2)C1c1c(F)c(F)c(F)c(F)c1F.COc1ccc(OCC2CO2)cc1>>COC(=O)C1=C(C)NC2=C(C(=O)CN(CC(O)COc3ccc(OC)cc3)C2)C1c1c(F)c(F)c(F)c(F)c1F,,CO,,Cl,,val
US04350703,O=C1NC2CC=CCC12.O=CC(=O)OCc1ccc([N+](=O)[O-])cc1>>O=C(OCc1ccc([N+](=O)[O-])cc1)C(O)N1C(=O)C2CC=CCC21,,c1ccccc1,,O,O,val
US20110098297A1,COC(=O)c1cc2cc(Oc3ccc(S(C)(=O)=O)cn3)cc(OC)c2[nH]1>>COc1cc(Oc2ccc(S(C)(=O)=O)cn2)cc2cc(C(=O)O)[nH]c12,,C1CCOC1,CCO,[Na+].[OH-],,val
US04923857,C/C(=C\[C@@H]1CCCN1)C1=C(C(=O)O)N2C(=O)[C@H]([C@@H](C)O)[C@H]2C1.N=COCc1ccccc1>>C/C(=C\[C@@H]1CCCN1C=N)C1=C(C(=O)O)N2C(=O)[C@H]([C@@H](C)O)[C@@H]2C1,,O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130005707A1,CC(=O)OC(C)=O.NNc1cc([N+](=O)[O-])ccn1>>CC(=O)NNc1cc([N+](=O)[O-])ccn1,,c1ccncc1,,Cl,Cl,val
US04994485,CCS(=O)c1sc(C#N)cc1C#N.Sc1ccccc1>>N#Cc1cc(C#N)c(Sc2ccccc2)s1,,CC#N,,CCN(CC)CC,,val
US20020082271A1,COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCCBr.C[C@H](O)CNCC(=O)OC(C)(C)C>>COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCCN(CC(=O)OC(C)(C)C)C[C@H](C)O,,CC#N,,CCN(C(C)C)C(C)C,,val
US20150315141A1,CC(C)(C)OC(=O)NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)C1(O)CCCc2ncccc21>>NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)C1(O)CCCc2ncccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20010006619A1,CNCCN1CCCCC1.O=C(O)Cc1ccc(Br)cc1>>CN(CCN1CCCCC1)C(=O)Cc1ccc(Br)cc1,CN(C)C=O,ClC(Cl)Cl,,CCN(CC)CC,O=S(Cl)Cl,val
US20100048881A1,COCCOC(=O)N=NC(=O)OCCOC.COc1ccc(O)cc1.C[C@@H](O)C[C@@H](C)O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(O)cc1.COc1ccc(O[C@@H](C)C[C@@H](C)O)cc1,,C1CCOC1,O,,,val
US20100331326A1,Brc1ccc2cccnc2c1.Cc1ccncc1N1CCNC1=O>>Cc1ccncc1N1CCN(c2ccc3cccnc3c2)C1=O,I[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20140371283A1,Fc1cc(F)cc(C2SCCCS2)c1.O=Cc1ccc(OC(F)F)cc1>>OC(c1ccc(OC(F)F)cc1)C1(c2cc(F)cc(F)c2)SCCCS1,,C1CCOC1,,[Li]CCCC,,val
US05240942,Cl.N#CCBr.c1ccc2c(C3CCNCC3)cccc2c1>>Cl.N#CCN1CCC(c2cccc3ccccc23)CC1,,CC(C)=O,,Br,O=C([O-])[O-].[K+].[K+],val
US20120114739A1,CCOC(=O)CC(=O)C1CCN(C(=O)OC(C)(C)C)C1.Nc1cc[nH]n1>>CC(C)(C)OC(=O)N1CCC(c2cc(O)n3nccc3n2)C1,,Cc1ccccc1,,,,val
US20090275578A1,COC(=O)c1c(CBr)ccc(F)c1I.NCc1ccc(OC(F)(F)F)cc1>>O=C1c2c(ccc(F)c2I)CN1Cc1ccc(OC(F)(F)F)cc1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US05998412,CN(C)S(=O)(=O)N1CCN(S(=O)(=O)N2CCC(c3cn(S(=O)(=O)CC[Si](C)(C)C)c4ccc(C#N)cc34)CC2)[C@@H](C(=O)NOCc2ccccc2)C1>>CN(C)S(=O)(=O)N1CCN(S(=O)(=O)N2CCC(c3c[nH]c4ccc(C#N)cc34)CC2)[C@@H](C(=O)NOCc2ccccc2)C1,,Cl,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20160030395A1,Cc1noc(C)c1-c1ccc2c(c1)C(O)(c1ccc(F)cc1)C(=O)N2.c1ccncc1>>Cc1noc(C)c1-c1ccc2c(c1)C(N)(c1ccc(F)cc1)C(=O)N2,,C1CCOC1,,O=S(Cl)Cl,,val
US20040014745A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(O)c1ccncc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)N1CCN(C(=O)Nc2ccncc2)CC1,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,,val
US07074819B2,COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2CCCCCCCCCO)cc1.CS(=O)(=O)Cl>>COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2CCCCCCCCCOS(C)(=O)=O)cc1,,ClCCl,,CCN(CC)CC,O,val
US20160000760A1,Nc1cc(Cl)c(-c2ccc(F)cc2)c(Cl)c1.S=C(n1ccnc1)n1ccnc1>>Fc1ccc(-c2c(Cl)cc(N=C=S)cc2Cl)cc1,,ClCCl,,,,val
US03946019,Cc1ccc(S(=O)(=O)N2C=Cc3cccc(-n4cccc4)c3C2C#N)cc1>>N#Cc1nccc2cccc(-n3cccc3)c12,,CN(C)C=O,,[H-].[Na+],,val
US20020193407A1,CCC(C)=O.COC(=O)CCCCCl>>CCC(=O)CC(=O)CCCCCl,,C1CCOC1,,[H-].[Na+],,val
US20110152300A1,CS(=O)(=O)c1ncc(F)c(N)n1.ON=Cc1ccccc1Cl>>Nc1nc(ON=Cc2ccccc2Cl)ncc1F,,C1CCOC1,,[H-].[Na+],,val
US20020165241A1,O=C(OCc1ccc(F)cc1)ON1C(=O)CCC1=O.c1cc(NCC2CCNCC2)cnn1>>O=C(OCc1ccc(F)cc1)N1CCC(CNc2ccnnc2)CC1,,CN(C)C=O,,,,val
US20040092402A1,BrBr.Cc1ccc(F)cc1Cl>>Cc1cc(Br)c(F)cc1Cl,[Fe],,,,,val
US20070244095A1,CCc1cc(C(=O)OC)c(NC(=O)OC(C)C)cc1C(F)(F)F.COC(=O)CCCBr>>CCc1cc(C(=O)OC)c(N(CCCC(=O)OC)C(=O)OC(C)C)cc1C(F)(F)F,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100099658A1,CC(C)S(=O)(=O)c1ccccc1N.Clc1nc(Cl)c2ccccc2n1>>CC(C)S(=O)(=O)c1ccccc1Nc1nc(Cl)nc2ccccc12,,O,,CN(C)C=O,[H-].[Na+],val
US20080181866A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(O)[C@@H]1Cc2ccccc2N1>>CC(C)(C)OC(=O)N1c2ccccc2C[C@H]1C(=O)O,,CN(C)C=O,,CCN(CC)CC,,val
US20090099175A1,COc1cc(C(C)=O)ccc1F.O=[N+]([O-])O>>COc1cc(C(C)=O)c([N+](=O)[O-])cc1F,,O,,,,val
US20040006114A1,CC(N)c1ccc(Br)cc1.CCS(=O)(=O)Cl>>CCS(=O)(=O)NC(C)c1ccc(Br)cc1,,ClCCl,,CCN(CC)CC,,val
US20070249670A1,C=[N+]=[N-].C[C@](NC(=O)OCC1c2ccccc2-c2ccccc21)(C(=O)O)C1CCCCC1>>COC(=O)[C@](C)(NC(=O)OCC1c2ccccc2-c2ccccc21)C1CCCCC1,,ClCCl,ClCCl,CC(=O)O,,val
US04207419,CC(=O)C(C)(C)c1ccccc1.CCOC=O>>CC(C)(C(=O)CC=O)c1ccccc1,,CCOCC,c1ccccc1,Cl,[H-].[Na+],val
US20100173925A1,CCO.O=C(NCC1CCN(CC2(C(=O)O)CCC2)CC1)N1C(=O)C2(CCCC2)c2ccc(F)cc21>>CC(C)(C)OC(=O)NCC1CCN(CC2(C(=O)O)CCC2)CC1,,CCO,,Cl,[Na+].[OH-],val
US20110201604A1,CCOC(=O)c1ccc(N)c(NC)c1.CN(C)C=O.Nc1nc2ccc(Cl)cc2s1>>CCOC(=O)c1ccc2nc(Nc3nc4ccc(Cl)cc4s3)n(C)c2c1,,CN(C)C=O,,ClCCCl,,val
US20140364595A1,CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O.CCCCCCCC(=O)OCCl>>C=C(CCCCCC)C(=O)[O-].CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O,,CC#N,,[I-].[Na+],,val
US20070249670A1,COCCOC[C@H](NC(=O)c1cc2ccccc2cc1N)C(=O)OC.Cc1cc(C)c(N=C=O)c(C)c1>>COCCOC[C@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C)C(=O)OC,,c1ccncc1,,,,val
US07396844B1,CC(C)(C)OC(=O)N[C@@H](COc1cc(C#N)ccc1I)CC(=O)OCc1ccccc1.Cl>>N#Cc1ccc(I)c(OC[C@H]([NH3+])CC(=O)OCc2ccccc2)c1.[Cl-],,C1COCCO1,,,,val
US20080194535A1,C=CCO[C@@H]1C[C@H](NC(=O)C(F)(F)F)c2cc(OC)ccc21>>C=CCO[C@@H]1C[C@H](N)c2cc(OC)ccc21,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US20090149441A1,C=C(OCC)c1ccc2nc(C(=O)Nc3ccccc3)cn2c1.Cl>>CC(=O)c1ccc2nc(C(=O)Nc3ccccc3)cn2c1.Cl,,ClCCl,,,,val
US20080108604A1,CCCCO.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=Cc1ccccc1[N+](=O)[O-]>>CCCCOC(OCCCC)c1ccccc1[N+](=O)[O-],,Cc1ccccc1,,O,,val
US20120083476A1,CC(C)(C)OC(=O)N1CCC2(CCNC2)CC1.O=C(Nc1cccnc1)Oc1ccccc1>>CC(C)(C)OC(=O)N1CCC2(CCN(C(=O)Nc3cccnc3)C2)CC1,,CC#N,CCOC(C)=O,Cl,,val
US20070060525A1,Br.N[C@@H](C(=O)O)C1CCCCC1>>O=C(O)[C@H](Br)C1CCCCC1,,O,,O=N[O-].[Na+],,val
US20160194358A1,Clc1ccc(-c2ccccc2)cn1.NC(N)=S>>Sc1ccc(-c2ccccc2)cn1,,CN1CCCC1=O,,,,val
US04859229,CC(C)Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(F)cc1Br.CI>>CC(C)Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Br,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20110245264A1,CC(C)(C)OC(=O)N[C@@H](C(=O)O)c1ccc(O)cc1.CC(C)(C)[Si](C)(C)Cl>>CC(C)(C)OC(=O)N[C@@H](C(=O)O)c1ccc(O[Si](C)(C)C(C)(C)C)cc1,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20140005212A1,CC(C)(C)C(=O)Cl.Nc1cc(Cl)cc(-c2ccc(Oc3ccc(F)cc3)cc2)n1>>CC(C)(C)C(=O)Nc1cc(Cl)cc(-c2ccc(Oc3ccc(F)cc3)cc2)n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120264734A1,CC(=O)C(F)C(C)=O.N#CCC(N)=O>>Cc1[nH]c(=O)c(C#N)c(C)c1F,,CCO,,C1CCNCC1,,val
US20100173944A1,CCCCCCCCCCOc1ccnc(COC(C)=O)c1C>>CCCCCCCCCCOc1ccnc(CO)c1C,,O,,[Na+].[OH-],,val
US20110110889A1,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)O)c1F.Cc1[nH]c2ncc(N)cc2c1C>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(C)c(C)c3c2)c1F,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20160152612A1,COC(=O)c1c(C)nc2ccc(C#N)cc2c1Cl.O=C1CCC(=O)N1Br>>COC(=O)c1c(CBr)nc2ccc(C#N)cc2c1Cl,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US04186135,C=CCN1CCCC1CN.CNS(=O)(=O)c1cc2c(c(C(=O)Cl)c1)OCCO2>>C=CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)NC)cc2c1OCCO2,,O,,ClC(Cl)Cl,,val
US20110275608A1,Nc1nc(Cl)ccc1C(=O)O.O=[N+]([O-])O>>Nc1nc(Cl)c([N+](=O)[O-])cc1C(=O)O,,O=S(=O)(O)O,,,,val
US20130071428A1,CC(C)(C)OC(=O)NCC(CO)(CNC(=O)OC(C)(C)C)CNC(=O)OC(C)(C)C.O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O>>CC(C)(C)OC(=O)NCC(CNC(=O)OC(C)(C)C)(CNC(=O)OC(C)(C)C)C(=O)O,,CCOC(C)=O,,CC#N,O,val
US20040006143A1,CC(C)(C)OC(=O)N(CCc1ccc(O)cc1)C[C@H](O)c1cccc(Cl)c1.CCOC(=O)COc1cccc(CO)c1>>CCOC(=O)COc1cccc(COc2ccc(CCN(C[C@H](O)c3cccc(Cl)c3)C(=O)OC(C)(C)C)cc2)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US03991197,COc1cc(C(C)=O)cc(OC)c1OC.O=Cc1ccncc1>>COc1cc(C(=O)C=Cc2ccncc2)cc(OC)c1OC,,O,,[Na+].[OH-],,val
US20130237628A1,CC(C)CNCC(C)C.Cc1ccc2sc3cc(C(=O)Cl)ccc3c(=O)c2c1>>Cc1ccc2sc3cc(C(N)=O)ccc3c(=O)c2c1,,ClCCl,O,CCN(CC)CC,,val
US20150141406A1,COC(=O)C1CCN(c2ccc([N+](=O)[O-])cc2)CC1>>COC(=O)C1CCN(c2ccc(N)cc2)CC1,[Fe],CO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20090247567A1,CC=O.CN(C(=O)c1cc2c(s1)-c1cc(C(N)=O)ccc1OCC2)c1ccccc1Cl>>CCNC(=O)c1ccc2c(c1)-c1sc(C(=O)N(C)c3ccccc3Cl)cc1CCO2,,CC#N,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20100298324A1,O=C(c1ccccc1)c1cccc(C[N+]23CN4CN(CN(C4)C2)C3)c1>>NCc1cccc(C(=O)c2ccccc2)c1,,CCO,,Cl,,val
US20150266881A1,COC(=O)c1cccc([C@@H]2C[C@H]2NC(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1cccc(C(=O)O)c1,,CO,,[Na+].[OH-],,val
US20100120669A1,N#CCCl.Oc1cc(Cl)c(Cl)cc1Cl>>N#CCOc1cc(Cl)c(Cl)cc1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05424329,CC(=O)Cl.CCOC(=O)c1cc2cc(O)ccc2n1C>>CCOC(=O)c1cc2cc(OC(C)=O)ccc2n1C,,C1CCOC1,O,CCN(CC)CC,,val
US20160194350A1,C=C(C)C[C@@H]1C[C@@H](COC(=O)c2ccccc2)O[C@H]1n1c(=O)sc2c(=O)[nH]c(N)nc21>>C=C(C)C[C@@H]1C[C@@H](CO)O[C@H]1n1c(=O)sc2c(=O)[nH]c(N)nc21,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20090018133A1,Cc1ccc2c(C(=O)NCC34CC5CC(CC(C5)C3)C4)c(Cl)ccc2n1.O=C(OO)c1cccc(Cl)c1>>O=C(NCC12CC3CC(CC(C3)C1)C2)c1c(Cl)ccc2nc(CO)ccc12,,ClCCl,,,,val
US20020072635A1,CCCCCCCCc1ccc(C(CC(COC(C)=O)(COC(C)=O)NC(C)=O)OC(C)=O)cc1>>CCCCCCCCc1ccc(C(O)CC(N)(CO)CO)cc1,,CO,O,[Na+].[OH-],,val
US20080227778A1,CO.COc1ccc2c(=O)n(C)c(CBr)c(-c3ccccc3)c2c1>>COCc1c(-c2ccccc2)c2cc(OC)ccc2c(=O)n1C,,CN(C)C=O,,[H-].[Na+],,val
US20150336935A1,C=C(C)OC(=O)Cl.COc1cc(OC)cc(C(=O)[C@H]2[C@H](C)[C@H](N)C[C@H]3C(C)(C)CCC[C@]23C)c1>>C=C(C)OC(=O)N[C@@H]1C[C@H]2C(C)(C)CCC[C@]2(C)[C@@H](C(=O)c2cc(OC)cc(OC)c2)[C@@H]1C,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20100016396A1,CCOP(=O)(CC#N)OCC.Cn1nc(C(F)(F)F)c(C=O)c1Oc1cc(O)c(Cl)cc1Cl>>Cn1nc(C(F)(F)F)c(/C=C/C#N)c1Oc1cc(O)c(Cl)cc1Cl,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20160137639A1,CC(C)(C)CC1CC(c2onc([C@H]3CN(C(=O)OC(C)(C)C)C[C@@H]3C(=O)OC(C)(C)C)c2I)C1.CC1(C)OB(C2CC2)OC1(C)C>>CC(C)(C)CC1CC(c2onc([C@H]3CN(C(=O)OC(C)(C)C)C[C@@H]3C(=O)OC(C)(C)C)c2C2CC2)C1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US05120758,O=Cc1cc(Oc2ccccc2)ccc1OCc1ccccc1.OO>>Oc1cc(Oc2ccccc2)ccc1OCc1ccccc1,,CO,,O=S(=O)(O)O,,val
US20020173469A1,Br.C1CCOC1.CC(C)COC(=O)Cl.CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)O>>CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)C(=O)CBr,,C1CCOC1,,CN1CCOCC1,,val
US20110130453A1,CCOC(=O)Cc1cccc(Oc2ccc(C(F)(F)F)cc2C=O)c1>>CCOC(=O)Cc1cccc(Oc2ccc(C(F)(F)F)cc2CO)c1,,CO,,[BH4-].[Na+],,val
US20160002228A1,CC(=O)c1c[nH]c2ncc(Br)cc12.Cc1ccc(S(=O)(=O)Cl)cc1>>CC(=O)c1cn(S(=O)(=O)c2ccc(C)cc2)c2ncc(Br)cc12,,C1CCOC1,,[H-].[Na+],,val
US20040242604A1,COc1ccc2ncnc(Nc3ccc(OC4CCNCC4)c(C)c3)c2c1.O=C=NC1CCCC1>>COc1ccc2ncnc(Nc3ccc(OC4CCN(C(=O)NC5CCCC5)CC4)c(C)c3)c2c1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US04720506,CC(C)C(=O)Cl.CCOC(=O)Cc1ccc(N)cc1>>CCOC(=O)Cc1ccc(NC(=O)C(C)C)cc1,,O,c1ccccc1,[Na+].[OH-],,val
US20050148645A1,CSC1=NC(=O)C(=O)N1C(C)C.N=C(N)Nc1ccc(Cl)c(Cl)c1>>CC(C)N1C(=O)C(=O)NC1=NC(=N)Nc1ccc(Cl)c(Cl)c1,,ClC(Cl)Cl,,,,val
US20100216760A1,CC(C)(O)CO.CCCCn1/c(=N/C(=O)c2cc(C(F)(F)F)ccc2F)sc2ccncc21>>CCCCn1/c(=N/C(=O)c2cc(C(F)(F)F)ccc2OCC(C)(C)O)sc2ccncc21,,C1CCOC1,,[H-].[Na+],,val
US04220795,CCOC1(CCCCCCCC(C)=O)OCCO1>>CC(=O)CCCCCCCCO,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110166123A1,BrBr.COc1ccc(C(=O)O)c(Cl)n1>>COc1nc(Cl)c(C(=O)O)cc1Br,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20130053380A1,COc1ccccc1S(=O)(=O)Cl.NC(Cc1ccccc1)CN1C(=O)c2ccccc2C1=O>>COc1ccccc1S(=O)(=O)NC(Cc1ccccc1)CN1C(=O)c2ccccc2C1=O,,c1ccncc1,,,,val
US04997840,CC(=O)c1ccccc1Cl.CN>>CNc1ccccc1C(C)=O,[Cu],Cl,,,,val
US04363813,CCOC(=O)c1sc(-c2cc(OC)c(OC)c(OC)c2)nc1C.NN>>COc1cc(-c2nc(C)c(C(=O)NN)s2)cc(OC)c1OC,,CCO,,O,,val
US20080207654A1,C1COCCN1.CCCc1nc(CC)c(C=O)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1>>CCCc1nc(CC)c(CN2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1,,CC(=O)O,CCOC(C)=O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05604229,CCCCCCCCCCCCCCCCC(COC(C)=O)(COC(C)=O)NC(C)=O.Cl>>CCCCCCCCCCCCCCCCC(N)(CO)CO.Cl,,CO,,[Na+].[OH-],,val
US20100010035A1,C[Si](C)(C)CCOCCl.Cc1ccc(S(=O)(=O)Nc2onc(C)c2C)s1>>Cc1ccc(S(=O)(=O)N(COCC[Si](C)(C)C)c2onc(C)c2C)s1,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20070099928A1,C1CNCCN1.CS(=O)(=O)Oc1ccc(OCCc2ccc(CC(SCCc3ccc(O)cc3)C(=O)O)cc2)cc1>>C1CNCCN1.CS(=O)(=O)Oc1ccc(OCCc2ccc(CC(SCCc3ccc(O)cc3)C(=O)O)cc2)cc1,,CCOC(C)=O,,,,val
US20100273744A1,O=C(Nc1ccn(Cc2ccc(CBr)cc2C(F)(F)F)n1)c1c(F)cccc1F.c1c[nH]nn1>>O=C(Nc1ccn(Cc2ccc(Cn3nccn3)cc2C(F)(F)F)n1)c1c(F)cccc1F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20030166639A1,CCOc1ccc(NC(=O)CC(=O)c2cccc(-c3cccnc3)c2)c(NC(=O)OC(C)(C)C)c1>>CCOc1ccc2c(c1)N=C(c1cccc(-c3cccnc3)c1)CC(=O)N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040067980A1,Cc1cc(Cl)nc(N)n1.Cc1cc(N)c2cc(C(=O)Nc3ccc(CN)cc3)ccc2n1>>Cc1cc(NCc2ccc(NC(=O)c3ccc4nc(C)cc(N)c4c3)cc2)nc(N)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20080312209A1,COC(=O)c1ncccc1-c1ccc(CN2C[C@H](C)N(C(=O)OC(C)(C)C)[C@H](C)C2)cc1>>C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)O)cc2)C[C@@H](C)N1C(=O)OC(C)(C)C,,C1COCCO1,O,[Li+].[OH-],,val
US20100273764A1,CC(C)OB(OC(C)C)OC(C)C.Cc1ccc(F)nc1>>Cc1cnc(F)c(B(O)O)c1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20090258876A1,Cc1ncccc1Oc1ccc(N(C)C(=O)c2cn(C(=O)OC(C)(C)C)c3ccccc23)cn1>>Cc1ncccc1Oc1ccc(N(C)C(=O)c2c[nH]c3ccccc23)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160194316A1,CCN(c1cc(Cl)cc(C(=O)OC)c1C)[C@@H]1COC[C@H]1O.COCCBr>>CCN(c1cc(Cl)cc(C(=O)O)c1C)[C@@H]1COC[C@H]1OCCOC,,CN(C)C=O,,[H-].[Na+],,val
US20040242660A1,Nc1ccc(N2CCOCC2=O)c(F)c1.O=C(NCC1CO1)c1ccc(Cl)s1>>O=C(NCC(O)CNc1ccc(N2CCOCC2=O)c(F)c1)c1ccc(Cl)s1,,CCO,,O,,val
US04477450,CCc1nc(Cl)cc(Cl)n1.NN>>CCc1nc(Cl)cc(NN)n1,,CO,,O,,val
US20100160430A1,CCCC(CCOS(C)(=O)=O)C(F)(F)F.COC(=O)CS(=O)(=O)CCC(F)(F)F>>CCCC(CCC(C(=O)OC)S(=O)(=O)CCC(F)(F)F)C(F)(F)F,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US07705042B2,N#Cc1ccc(C(=O)Nc2ccc(N3CCSCC3)cc2N2CCCCC2)o1.O=[Os](=O)(=O)=O>>N#Cc1ccc(C(=O)Nc2ccc(N3CCS(=O)(=O)CC3)cc2N2CCCCC2)o1,O=[Os](=O)(=O)=O,CC(C)=O,O,C[N+]1([O-])CCOCC1,,val
US06284915B1,CCC(CC)C(N)=O.CCCCCCCC(=O)c1ccc(CCI)cc1.O=C(O)CC(=O)O>>CCC(CC)C(N)=O.CCCCCCCC(=O)c1ccc(CCOC(=O)CC(=O)[O-])cc1,,CCO,,C,C[O-].[Na+],val
US20090082339A1,C=CS(C)(=O)=O.O=[N+]([O-])c1ccc(N2CCCNCC2)cc1>>CS(=O)(=O)CCN1CCCN(c2ccc([N+](=O)[O-])cc2)CC1,,CO,,,,val
US20120225867A1,CC(=O)c1nc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3)n2)co1>>CC(O)c1nc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3)n2)co1,,CCO,,[BH4-].[Na+],,val
US04690931,CCc1ccc(C(=O)C(C)Br)cc1.c1ccc(CC2CCNCC2)cc1>>CCc1ccc(C(=O)C(C)N2CCC(Cc3ccccc3)CC2)cc1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20140357639A1,OCc1cn2c(n1)-c1ccccc1CC2>>O=Cc1cn2c(n1)-c1ccccc1CC2,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05767131,C1CCC(C2CCNCC2)CC1.C=CC#N>>N#CCCN1CCC(C2CCCCC2)CC1,,CCO,,,,val
US20020156296A1,CC(C)(C)C(=O)Cl.COc1ccc(O)c(C(C)(C)C)c1>>COc1ccc(OC(=O)C(C)(C)C)c(C(C)(C)C)c1,,CN(C)C=O,,[H-].[Na+],,val
US20050096337A1,COCc1nc(-c2ccc(C(F)(F)F)cc2)nc(C2CC2)c1CO.O=S(Cl)Cl>>COCc1nc(-c2ccc(C(F)(F)F)cc2)nc(C2CC2)c1CCl,,ClCCl,,,,val
US20120202785A1,C[C@H](N)c1nc2ccc(F)cc2n1C1CC(C#N)C1.Clc1ncnc2c1ncn2C1CCCCO1>>C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2n1C1CC(C#N)C1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US04562198,CC(C)(C(=O)CCl)C(Br)CBr.Oc1ccc(Cl)cc1>>CC(C)(C(=O)COc1ccc(Cl)cc1)C(Br)CBr,,Cc1ccccc1,,O,O=C([O-])[O-].[K+].[K+],val
US20060199795A1,CC(C)(C)OC(=O)NCc1cccc(C(=O)N2CCOc3nccc(-c4ccc(F)cc4)c3C2)c1.Cl>>Cl.NCc1cccc(C(=O)N2CCOc3nccc(-c4ccc(F)cc4)c3C2)c1,,CCOC(C)=O,,,,val
US20090012126A1,CC(C)(C)OC(=O)NCCCBr.[N-]=[N+]=NC[C@H]1CCC(=O)N1>>CC(C)(C)OC(=O)NCCCN1C(=O)CC[C@@H]1CN=[N+]=[N-],,CN(C)C=O,,[H-].[Na+],,val
US05171731,CC(Br)C(=O)c1ccccc1.Cc1nc2cc(Cl)c(Cl)cc2n1C(C)C>>Cc1c(-c2ccccc2)cc2n(C(C)C)c3cc(Cl)c(Cl)cc3n12,,CC(C)=O,,COc1ccccc1,,val
US20100249163A1,C=CCBr.COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(O)c2ccc(F)c(F)c2)C2CC2)cc(OCCOC)c1>>C=CCO[C@]1(c2ccc(F)c(F)c2)CCN(C(=O)OC(C)(C)C)C[C@@H]1C(=O)N(Cc1cc(CCCOC)cc(OCCOC)c1)C1CC1,,CN(C)C=O,,[H-].[Na+],,val
US20080280910A1,NN.O=C1OC(=Cc2ccc(F)c(Br)c2)C2=C1CCCC2>>O=c1[nH]nc(Cc2ccc(F)c(Br)c2)c2c1CCCC2,,O,,,,val
US05747517,CC(C)(C)c1ccc(Sc2ccc(C=O)cc2)cc1.O=C1CSC(=S)N1>>CC(C)(C)c1ccc(Sc2cccc(C=C3SC(=S)NC3=O)c2)cc1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20080207695A1,CCOC(=O)CC1=C(C)CCN(N=O)C1=O>>CCOC(=O)CC1=C(C)CCN(N)C1=O,[Zn],CC(=O)O,CO,,,val
US20100048532A1,CC(C)(C)[Si](C)(C)OCCCBr.Cc1nc2c3c(c(C(=O)N(C)C)cc2[nH]1)CCC(c1ccc(F)cc1)O3>>Cc1nc2cc(C(=O)N(C)C)c3c(c2n1CCCO[Si](C)(C)C(C)(C)C)OC(c1ccc(F)cc1)CC3,,CN(C)C=O,,[H-].[Na+],,val
US20040186114A1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1c(N)cc(C(C)(C)C)cc1NS(C)(=O)=O.O=C(O)c1cc2ccccc2[nH]1.On1nnc2cccnc21>>COc1c(NC(=O)c2cc3cccc(Oc4ccnc(CN(C)C)c4)c3n2C)cc(C(C)(C)C)cc1NS(C)(=O)=O,,CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US20060235033A1,CC(N)c1ccc(F)cc1.COc1cc2nccc(Oc3ccc(N)c(F)c3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)NC(C)c4ccc(F)cc4)c(F)c3)c2cc1OC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20120101086A1,Cc1c2c(nn1-c1nnc(-c3ccc(OC(C)C)c(C#N)c3)s1)CCN(CCO)C2.Cl>>Cc1c2c(nn1-c1nnc(-c3ccc(OC(C)C)c(C#N)c3)s1)CCN(CCO)C2.Cl,,CO,,CCOCC,,val
US20040073025A1,OCc1ccccc1-c1cnccn1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=NCc1ccccc1-c1cnccn1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US09388125B2,CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)c1cc[nH]n1.NCc1ccc(OCCCO)c(Br)c1>>CC(C)(C)OC(=O)NC(=N)N(Cc1ccc(OCCCO)c(Br)c1)C(=O)OC(C)(C)C,,CO,,CCN(C(C)C)C(C)C,Cl,val
US20070249637A1,CC(C)(C)OC(=O)Nc1cccc(Br)n1.CC(C)I>>CC(C)N(C(=O)OC(C)(C)C)c1cccc(Br)n1,,CN(C)C=O,,[H-].[Na+],,val
US03984465,COc1cccc(Cl)c1Cl.O=C(Cl)CCCCCCBr>>COc1ccc(C(=O)CCCCCCBr)c(Cl)c1Cl,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20110105509A1,Cc1c(Br)c2ccccc2n1C(=O)OC(C)(C)C.OB(O)c1cncc2ccccc12>>Cc1c(-c2cncc3ccccc23)c2ccccc2n1C(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US04831190,O=C(O)c1c(F)c(O)c(F)c(F)c1C(=O)O>>O=C(O)c1cc(F)c(F)c(O)c1F,,O,,,,val
US20050176994A1,Br[Mg]c1ccccc1.CCOC(=O)/C=C/C(=O)c1ccc(OC)c(OC)c1>>COc1ccc(C(=O)/C=C/C(=O)c2ccccc2)cc1OC,,C1CCOC1,,[Cl-].[NH4+],,val
US05543534,CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCC3O)cc1.C[Si](C)(C)Cl>>CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCC3O[Si](C)(C)C)cc1,,ClCCl,,CCN(CC)CC,,val
US20070203159A1,COc1ccc(Cn2cnc3c(Cl)ncnc32)cc1.ClC(Cl)(Br)C(Cl)(Cl)Br>>COc1ccc(Cn2c(Br)nc3c(Cl)ncnc32)cc1,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20100316656A1,CNC(COc1cc(C(C)(C)O[SiH2]C(C)(C)C)cc(C(C)(C)O[SiH2]C(C)(C)C)c1)C(=O)OC(C)(C)C.Cl>>CNCCOc1cc(CO)cc(CO)c1.Cl,,C1COCCO1,,,,val
US20110005947A1,NC(=O)c1cnc(Cl)cc1Cl.NCc1cccnc1>>NC(=O)c1cnc(Cl)cc1NCc1cccnc1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US08648068B2,Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCCN(C(=O)OC(C)(C)C)C3)c12.Cn1ccc(N)n1>>Cc1c(C(=O)Nc2ccn(C)n2)sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCCN(C(=O)OC(C)(C)C)C3)c12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140275030A1,CCC1(c2ccccn2)COc2cccc([N+](=O)[O-])c2N1>>CCC1(c2ccccn2)COc2cccc(N)c2N1,,CO,,,,val
US20010046975A1,C=[N+]=[N-].CC(C)(CC(=O)Oc1ccccc1C(C)(C)C)NS(=O)(=O)C(F)(F)F>>CN(C(C)(C)CC(=O)Oc1ccccc1C(C)(C)C)S(=O)(=O)C(F)(F)F,,CCOCC,,,,val
US20110021537A1,CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)OCc3ccccc3)n(-c3ccccc3)n2)CC1>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)O)n(-c3ccccc3)n2)CC1,,CCOC(C)=O,,,,val
US04977167,O=C1CCCN1.O=C=NCCCl>>O=C1CCCN1C(=O)NCCCl,,CCOC(C)=O,Cc1ccccc1,,,val
US20060270714A1,COc1ccnc(Cl)c1.NCCO>>COc1ccnc(NCCO)c1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20100210595A1,Cn1ccc2ccc([N+](=O)[O-])cc21.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cn1cc(C(=O)C(F)(F)F)c2ccc([N+](=O)[O-])cc21,,C1CCOC1,,,,val
US20090227799A1,Brc1ccc2c(c1)CCO2.CN(C)C=O>>O=Cc1ccc2c(c1)CCO2,,C1CCOC1,,Cl,[Li]CCCC,val
US06555542B1,CCOS(=O)(=O)CP(=O)(CC)CC.Cc1ccc(C=O)s1>>CCOS(=O)(=O)C=Cc1ccc(C)s1,,C1CCOC1,,[Li]CCCC,,val
US20030162772A1,CC(C)(C)OC(=O)NC1CCNCC1.ClCc1ccc(Cl)c(Cl)c1>>NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1,,CCN(CC)CC,CN(C)C=O,,,val
US05374641,COC(=O)Cc1ccc(CC(N)c2cccnc2)cc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>COC(=O)Cc1ccc(CC(NS(=O)(=O)c2ccc(Cl)cc2)c2cccnc2)cc1,,ClCCl,,CCN(CC)CC,O,val
US05134142,CC(=O)OC(C)=O.CS(=O)(=O)c1ccc(-c2cc(N)nn2-c2ccc(F)cc2)cc1>>CC(=O)Nc1cc(-c2ccc(S(C)(=O)=O)cc2)n(-c2ccc(F)cc2)n1,,ClCCl,,,,val
US03950333,CSC(=NCCSCc1cc[nH]n1)NC#N.NCCSCc1cc[nH]n1>>N#CNC(=N)NCCSCc1cc[nH]n1,,CCO,,,,val
US20050272778A1,COC(=O)c1c(O)cccc1OCCCCN.Cc1cc(C[C@H](NC(=O)OCc2ccccc2)C(=O)O)ccc1C1CC(=O)NS1(=O)=O>>COC(=O)c1c(O)cccc1OCCCCNC(=O)[C@H](Cc1ccc(C2CC(=O)NS2(=O)=O)c(C)c1)NC(=O)OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US05843983,CCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCC.COc1cc(CCc2cc(F)ccc2OCC[C@@H]2C[C@@H](O)CN2C)ccc1F>>CCCCCCCCCCCC(=O)O[C@@H]1C[C@@H](CCOc2ccc(F)cc2CCc2ccc(F)c(OC)c2)N(C)C1,CN(C)c1ccncc1,c1ccncc1,,CCOC(C)=O,,val
US20110059999A1,CCOC(C)OC(COc1ccccc1)C1CCC(C#N)(N(C)C)CC1.Cl[Mg]c1ccccc1>>CCOC(C)OC(COc1ccccc1)C1CCC(c2ccccc2)(N(C)C)CC1,,C1CCOC1,,O,[Cl-].[NH4+],val
US20080281105A1,COc1ccc2c(ccc(C)[n+]2C)c1.Cc1cc(C=O)c(C)n1-c1ccccc1.O=S(=O)([O-])C(F)(F)F>>COc1ccc2c(ccc(/C=C/c3cc(C)n(-c4ccccc4)c3C)[n+]2C)c1.O=S(=O)([O-])C(F)(F)F,C1CCNCC1,CO,,,,val
US20140051672A1,CN1C(C)(C)CC(N)CC1(C)C.Clc1ccc(-c2cc3ccccc3s2)nn1>>CN1C(C)(C)CC(Nc2ccc(-c3cc4ccccc4s3)nn2)CC1(C)C,,CCCCO,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US05206259,BrP(Br)Br.Cc1ccc(Sc2ccc(CO)cc2)cc1>>Cc1ccc(Sc2ccc(CBr)cc2)cc1,,CCOCC,,,,val
US20160175289A1,BrC(Br)(Br)Br.C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCO)cc2F)N1CC(C)(C)F>>C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCBr)cc2F)N1CC(C)(C)F,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20080114062A1,CN(C)C(=O)CCCC#Cc1cccc(C(=O)O)c1.NC1CC1>>CN(C)C(=O)CCCC#Cc1cccc(C(=O)NC2CC2)c1,,ClCCl,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US20140256700A1,COC(=O)C1(F)CC2CCC1O2>>OC[C@@]1(F)C[C@@H]2CC[C@H]1O2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060025474A1,CCC(CC)(c1ccc(O)c(C)c1)c1ccc(/C=C/C(O)(C(F)(F)F)C(F)(F)F)c(C)c1.COCCl>>CCC(CC)(c1ccc(O)c(C)c1)c1ccc(/C=C/C(OCOC)(C(F)(F)F)C(F)(F)F)c(C)c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20100113502A1,CCS(=O)(=O)n1c2c(c3cc(C(=O)OCc4ccccc4)ccc31)CN(C(=O)OC(C)(C)C)CC2>>CCS(=O)(=O)n1c2c(c3cc(C(=O)O)ccc31)CN(C(=O)OC(C)(C)C)CC2,[Pd],CO,,,,val
US05677302,CCCCn1sc2nc3ccccc3n2c1=O.N#CBr>>Brc1nsc2nc3ccccc3n12,,ClCCl,,,,val
US06476045B2,O=C(/C=C/c1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1>>O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1,,CO,c1ccncc1,O,[BH4-].[Na+],val
US20140206681A1,COC(=O)C1CCC2CCC(=O)N2C1>>O=C(O)[C@H]1CC[C@H]2CCC(=O)N2C1,,CO,O,Cl,C[O-].[Na+],val
US20080207654A1,CCCCc1nn(-c2ccc3c(c2)CC(C)(C)O3)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCCc1nn(-c2ccc3c(c2)CC(C)(C)O3)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US05496872,CCOC(=O)[C@@H](N)CSSC[C@H](N)C(=O)OCC>>CCOC(=O)[C@@H](N)CSSC[C@H](N)C(=O)OCC,,O,,CCN=C=NCCCN(C)C,Cl,val
US06107291,COc1ccc(S(=O)(=O)N2CC=CCC(C(=O)OCc3ccccc3)C2C(=O)OC(C)(C)C)cc1>>COc1ccc(S(=O)(=O)N2CC=CCC(C(=O)OCc3ccccc3)C2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150299189A1,COC(=O)c1cc(Cl)ccc1Nc1ccc2c(ccn2CC2CC2)c1>>O=C(O)c1cc(Cl)ccc1Nc1ccc2c(ccn2CC2CC2)c1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20050213413A1,CC(=O)Br.COc1ccc(C2(O)C(c3ccccc3)=C(c3ccccc3)C(c3ccccc3)=C2c2ccccc2)cc1>>COc1ccc(C2(Br)C(c3ccccc3)=C(c3ccccc3)C(c3ccccc3)=C2c2ccccc2)cc1,,Cc1ccccc1,,CO,,val
US04874775,Clc1ccc(NCc2cccnc2)cc1.O=S(=O)(Cl)CCl>>O=S(=O)(CCl)N(Cc1cccnc1)c1ccc(Cl)cc1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US04133809,CC(=O)OC1C(=O)N(c2ccccc2)c2cc(Cl)ccc2-n2cnnc21>>O=C1C(O)c2nncn2-c2ccc(Cl)cc2N1c1ccccc1,,CCO,,CC(=O)O,[Na+].[OH-],val
US20100280070A1,O=C1CC(c2ccccc2)Nc2c(Br)cc(Br)cc21.O=Cc1ccncc1>>O=c1c(Cc2ccncc2)c(-c2ccccc2)[nH]c2c(Br)cc(Br)cc12,,ClC(Cl)Cl,,C1CCNCC1,,val
US20100197634A1,Cc1ccc(C(C)(C)C)cc1Nc1nc2ccc(F)cc2c2c(Cl)nccc12.O=C([O-])O>>Cc1ccc(C(C)(C)C)cc1Nc1nc2ccc(F)cc2c2c(=O)[nH]ccc12,,C1CCOC1,,Cl,,val
US20070105820A1,CCOC(=O)N=NC(=O)OCC.O=C1N(Cc2ccc(Cl)cc2)c2ccccc2C1(O)c1ccc2c(c1)OCO2>>CCOC(=O)NN(C(=O)OCC)C1(c2ccc3c(c2)OCO3)C(=O)N(Cc2ccc(Cl)cc2)c2ccccc21,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05763450,C1CCOC1.CN(C)c1ccncc1.Nc1cccc(I)c1.O=C(Cl)C1CC1>>O=C(C1CC1)N(C(=O)C1CC1)c1cccc(I)c1,CN(C)c1ccncc1,,,CCN(CC)CC,Cl,val
US20040044203A1,CC(=O)N1CCN(c2cc(C)c(N)c([N+](=O)[O-])c2)CC1>>CC(=O)N1CCN(c2cc(C)c(N)c(N)c2)CC1,[Pd],CC(=O)O,,CO,[H][H],val
US20160185778A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.O=C(n1ccnc1)C1(C(F)(F)F)CC1>>CC(C)(C)OC(=O)N1CCC(=O)C(C(=O)C2(C(F)(F)F)CC2)C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120295882A1,CC(C)(C)OC(=O)N1CCc2c(oc3cc(S(=O)(=O)c4cccc(F)c4)ccc23)C1(C)C>>CC1(C)NCCc2c1oc1cc(S(=O)(=O)c3cccc(F)c3)ccc21,,Cl,,C1COCCO1,,val
US06268363B1,Brc1cccc2ccccc12.O=C(O)/C=C\C(=O)O>>O=C(O)C=CC(=O)c1cccc2ccccc12,,C1CCOC1,,O,,val
US20110112158A1,O=c1c2cc(COc3ccc(-c4cc(F)c(F)cc4F)cc3)ccc2on1C(c1ccccc1)(c1ccccc1)c1ccccc1>>Oc1noc2ccc(COc3ccc(-c4cc(F)c(F)cc4F)cc3)cc12,,C1CCOC1,,CO,Cl,val
US20040180897A1,Nc1ccncc1NC(=O)c1c(I)cc[nH]c1=O>>O=c1[nH]ccc(I)c1-c1nc2cnccc2[nH]1,,c1ccncc1,,O=P(Cl)(Cl)Cl,O=C([O-])O.[Na+],val
US20130116216A1,CN(C)C(=O)C1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)CC1>>CN(C)C(=O)C1CCN(S(=O)(=O)c2ccc(N)cc2)CC1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20140296208A1,COc1c(N)cc(C(C)(C)C)cc1CO.O=C(Cl)Oc1ccccc1>>COc1c(CO)cc(C(C)(C)C)cc1NC(=O)Oc1ccccc1,,C1CCOC1,ClCCl,O=C([O-])O.[Na+],,val
US03976635,CCOC(=O)C(C#N)=NOC(=O)OC.COC(=O)N[C@@H](Cc1ccccc1)C(=O)O>>COC(=O)N[C@@H](Cc1ccccc1)C(=O)OC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20050124623A1,CCOC(=O)c1c[nH]c2c(O)ncnc12.O=P(Cl)(Cl)Cl>>CCOC(=O)c1c[nH]c2c(Cl)ncnc12,,CCOCC,,,,val
US20120114739A1,C1COCCN1.C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)c1cc(Cl)nc2c(-c3cnc4ccccc4c3)cnn12>>C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)c1cc(N2CCOCC2)nc2c(-c3cnc4ccccc4c3)cnn12,,CN1CCCC1=O,O,O=C([O-])O.[Na+],,val
US05162328,NS(=O)(=O)O.c1cc(Nc2nccc(-c3cccs3)n2)cc(OCCn2ccnc2)c1>>NS(=O)(=O)O.c1cc(Nc2nccc(-c3cccs3)n2)cc(OCCn2ccnc2)c1,,CCO,,,,val
US04831041,COC(=O)N(C)c1cccc(C)c1CO.CS(=O)(=O)Cl>>COC(=O)N(C)c1cccc(C)c1CCl,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20090118300A1,CC(C)(C)O.CC(C)(C)OC(=O)N1CCC(O)(c2cc(C=O)c3ccccc3c2)CC1>>CC(C)(C)OC(=O)N1CCC(O)(c2cc(C(=O)O)c3ccccc3c2)CC1,,CC(C)(C)O,O,CC=C(C)C,[Na+].[O-]Cl,val
US20030171396A1,CCCCCS(=O)(=O)NC(=O)c1ccc2nc(C)n(Cc3ccc(N(CC)C(=O)OC(C)(C)C)cc3Cl)c2n1>>CCCCCS(=O)(=O)NC(=O)c1ccc2nc(C)n(Cc3ccc(NC)cc3Cl)c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150266881A1,Cc1nnc(NC(=O)c2cccc([C@@H]3C[C@H]3N)c2)s1.Cl.Cl.O=C1CCC1>>Cc1nnc(NC(=O)c2cccc([C@@H]3C[C@H]3NC3CCC3)c2)s1.Cl.Cl,,CC(=O)O,CO,O=C([O-])O.[Na+],,val
US20110028465A1,CC(C)(c1ccc2c(n1)CC[C@H](C(=O)O)C2)C(F)(F)F.Nc1cnc2c(c1)COCC2>>CC(C)(c1ccc2c(n1)CCC(C(=O)Nc1cnc3c(c1)COCC3)C2)C(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140315889A1,COC(=O)c1ccc(CCBr)cc1.Cc1c[nH]c2c1C(=O)CC(C)(C)C2>>COC(=O)c1ccc(Cn2cc(C)c3c2CC(C)(C)CC3=O)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20160096827A1,N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1OC1CCNCC1.O=CNCC(=O)O>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1OC1CCN(C(=O)CNC=O)CC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020192722A1,CC(C)(C)[Si](OCCOCCOCCOCCCCCCCCCCCC(=O)NCCSSCCNC(=O)CCCCCCCCCCCOCCOCCOCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)(c1ccccc1)c1ccccc1>>O=C(CCCCCCCCCCCOCCOCCOCCO)NCCSSCCNC(=O)CCCCCCCCCCCOCCOCCOCCO,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05270309,C=C(C)c1cccc([N+](=O)[O-])c1>>CC(C)c1cccc(N)c1,[Pd],,,[H][H],,val
US20100222393A1,O=C(CBr)C(O)(c1ccccc1)C1CCCCC1.c1c[nH]cn1>>O=C(Cn1ccnc1)C(O)(c1ccccc1)C1CCCCC1,,ClCCl,,CCN(CC)CC,,val
US20100144695A1,Cn1ccnc1Br.O=C1CCC2(CC1)OCCO2>>Cn1ccnc1C1(O)CCC2(CC1)OCCO2,,C1CCOC1,,,,val
US20060194813A1,CCOC(=C1C(=O)N(C(C)=O)c2cc(Cl)ccc21)c1ccccc1.CN(C)C(=O)CNc1ccc(N)cc1>>CN(C)C(=O)CNc1ccc(N/C(=C2\C(=O)Nc3cc(Cl)ccc32)c2ccccc2)cc1,,CN(C)C=O,,O,,val
US20140091283A1,BrP(Br)Br.OCc1cc2cc3ccccc3cc2s1>>BrCc1cc2cc3ccccc3cc2s1,,CO,,CCOCC,,val
US20100280083A1,COc1cc(-c2noc(C)n2)c(C(=O)c2ccccc2)cc1OCc1ccccc1>>COc1cc(-c2noc(C)n2)c(C(=O)c2ccccc2)cc1O,Cl[Ti](Cl)(Cl)Cl,CCOC(C)=O,,Cl,ClCCl,val
US20090275627A1,C#CCC(N)c1ccccc1.O=C=NCCCl>>C#CCC(NC(=O)NCCCl)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20080146636A1,CC(C)(C)OC(=O)N[C@H]1CC[C@H](N)C1.Cc1ccc(F)c([N+](=O)[O-])c1>>Cc1ccc(N[C@H]2CC[C@H](NC(=O)OC(C)(C)C)C2)c([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030114311A1,CCN(CC)S(F)(F)F.COC(=O)c1nc(-c2ccc(CO)cc2)cc(N)c1Cl>>COC(=O)c1nc(-c2ccc(CF)cc2)cc(N)c1Cl,,ClCCl,,,,val
US20080015199A1,COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc2c(c(OC)c1)OCOC2.NNc1ncccn1>>COc1cc(C(Nc2ccc(-c3noc(C)n3)cc2)c2nn(-c3ncccn3)c(=O)[nH]2)cc2c1OCOC2,,CN(C)C=O,,CCN(CC)CC,,val
US05646173,COc1ccc2c(c1)C(=O)C(C(C)C(C)=O)C2.C[C@@H](O)CN>>COc1ccc2c(c1)-c1c(c(C)c(C)n1C[C@@H](C)O)C2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140038941A1,CCN(CC)C(=O)c1ccn2c(I)c(C(C)C)nc2c1.SC1CCCCC1>>CCN(CC)C(=O)c1ccn2c(SC3CCCCC3)c(C(C)C)nc2c1,I[Cu]I,CS(C)=O,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20100133519A1,Nc1ccc(I)cc1.c1ccc2c(c1)[nH]c1ccccc12>>Nc1ccc(-n2c3ccccc3c3ccccc32)cc1,O=[Cu-],c1ccc(Oc2ccccc2)cc1,,,,val
US20160221973A1,COC(=O)c1ccc2c(c1)OC[C@H](c1ccc(F)cc1)NC2.O=C(Cl)N1CCOCC1>>COC(=O)c1ccc2c(c1)OC[C@H](c1ccc(F)cc1)N(C(=O)N1CCOCC1)C2,,ClCCl,,CCN(CC)CC,Cl,val
US20050054639A1,C=CCc1ccccc1Cl.O=C(OO)c1cccc(Cl)c1>>Clc1ccccc1CC1CO1,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US04242344,C1CNCCN1.CN(C)S(=O)(=O)c1cnc2cnc(Cl)cn12>>CN(C)S(=O)(=O)c1cnc2cnc(N3CCNCC3)cn12.Cl,,CC#N,,,,val
US20070088041A1,COc1nnc(-c2ccncc2)cc1-c1[nH]c2cc(CN3CCCCC3)ccc2c1-c1ccccc1>>O=c1[nH]nc(-c2ccncc2)cc1-c1[nH]c2cc(CN3CCCCC3)ccc2c1-c1ccccc1,,CCO,,[Na+].[OH-],,val
US20110263564A1,CC(C(=O)O)c1cccc(-c2cccc(C(F)(F)F)c2)n1.Nc1cnccn1>>CC(C(=O)Nc1cnccn1)c1cccc(-c2cccc(C(F)(F)F)c2)n1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05968967,N#Cc1ccc(N)cc1.O=N[O-]>>N#Cc1ccc(NN)cc1,,O,,Cl,,val
US20020132776A1,CC(C)(C)OC(=O)CN.NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1>>CC(C)(C)OC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1,,CN(C)C=O,,CN1CCOCC1,Cl,val
US20080167289A1,CCOC(=O)N1CCC(N)CC1.CN1C(=O)CCN(C2CCCC2)c2nc(Cl)ncc21>>CCOC(=O)N1CCC(Nc2ncc3c(n2)N(C2CCCC2)CCC(=O)N3C)CC1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20150361125A1,C=C1C[C@H]2[C@@H](CC[C@@]3(C)C(=O)CC[C@H]23)[C@]2(C)CC[C@H](O)C[C@@H]12.O=Cc1ccccc1>>C=C1C[C@H]2[C@@H](CC[C@@]3(C)C(=O)C(=Cc4ccccc4)C[C@H]23)[C@]2(C)CC[C@H](O)C[C@@H]12,,CCO,,[K+].[OH-],,val
US20100137276A1,Cc1ccc(I)c(F)c1.O=C1CCC(=O)N1Br>>Fc1cc(CBr)ccc1I,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,ClCCl,,,val
US04242267,CCCCCCc1cc(S(C)(=O)=NS(=O)(=O)c2ccc(C)cc2)ccc1OC(=O)c1ccccc1>>CCCCCCc1cc(S(C)(=O)=NS(=O)(=O)c2ccc(C)cc2)ccc1O,,CO,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20060173018A1,Cc1ccc2c(N3CC[C@@H](N)C3)nc(-c3c(O)cccc3F)nc2c1.O=C(O)C1CC1>>Cc1ccc2c(N3CC[C@@H](NC(=O)C4CC4)C3)nc(-c3c(O)cccc3F)nc2c1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090197866A1,CN1CCCN(c2cc(N)c(N)cc2F)CC1.O=Cc1nn(C2CCCCO2)cc1[N+](=O)[O-]>>CN1CCCN(c2cc3[nH]c(-c4nn(C5CCCCO5)cc4[N+](=O)[O-])nc3cc2F)CC1,,CN(C)C=O,,,,val
US20070105919A1,CCOC(=O)c1ccco1.Cc1ccncc1C>>Cc1cnccc1CC(=O)c1ccco1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US05110956,Cc1cc2c(cc1C(C)SCC(=O)O)OCO2.O=C(OO)c1cccc(Cl)c1>>Cc1cc2c(cc1C(C)S(=O)CC(=O)O)OCO2,,ClC(Cl)Cl,,,,val
US20090156801A1,OC(COC(c1ccccc1)(c1ccccc1)c1ccccc1)COC(c1ccccc1)(c1ccccc1)c1ccccc1.Oc1ccc(I)cc1>>Ic1ccc(OC(COC(c2ccccc2)(c2ccccc2)c2ccccc2)COC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05582767,CCCc1cc(F)cc(F)c1.II>>CCCc1cc(F)c(I)c(F)c1,,C1CCOC1,CCCCCC,[Li]CCCC,O=C([O-])O.[Na+],val
US20150252030A1,Cc1cc([N+](=O)[O-])cc(C)c1OCC(=O)NN.O=Cc1cccc2[nH]ccc12>>Cc1cc([N+](=O)[O-])cc(C)c1OCC(=O)N/N=C/c1cccc2[nH]ccc12,,CCO,,,,val
US20070249579A1,CC(C)(C)OC(=O)N1CCN(c2c[nH]nc2-c2ccccc2)CC1.ClCc1ccccn1>>CC(C)(C)OC(=O)N1CCN(c2cn(Cc3ccccn3)nc2-c2ccccc2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20060111375A1,COc1cc2c(Cl)ccnc2cc1OCc1ccccc1.Cc1ccc(-c2nc(C)c(C)cc2O)nc1>>COc1cc2c(Oc3cc(C)c(C)nc3-c3ccc(C)cn3)ccnc2cc1OCc1ccccc1,CN(C)c1ccncc1,CS(C)=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070111986A1,Nc1ccccc1Sc1ccccc1.O=C(Cl)Cl.OCCOCCN1CCNCC1>>O=C(Nc1ccccc1Sc1ccccc1)N1CCN(CCOCCO)CC1,,CCN(CC)CC,Cc1ccccc1,,,val
US06133485,C[C@@H](O)[C@]1(c2ccc(F)cc2F)CO1.c1nc[nH]n1>>C[C@@H](O)[C@@](O)(Cn1cncn1)c1ccc(F)cc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150191478A1,COc1ccccc1NC(=O)c1cncc2cc(C=O)oc12.O=C1CSC(=S)N1>>COc1ccccc1NC(=O)c1cncc2cc(/C=C3\SC(=S)NC3=O)oc12,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20050070582A1,COc1ccc(Br)cc1.O=S(=O)(O)Cl>>COc1ccc(Br)cc1S(=O)(=O)Cl,,ClC(Cl)Cl,,,,val
US06093710,CC(=O)Cl.N#Cc1cc2c(s1)SCCN2>>CC(=O)N1CCSc2sc(C#N)cc21,,ClCCl,O,CCN(CC)CC,CCOC(C)=O,val
US20120258953A1,CC(C)(C)OC(=O)N1CCOc2ccc(-c3ccc(C(=O)O)cc3)cc2C1.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1CCOc2ccc(-c3ccc(C(=O)Cl)cc3)cc2C1,CN(C)C=O,Cc1ccccc1,,c1ccncc1,,val
US04245088,CC(=O)CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1.Cc1nnc(S)s1>>Cc1nnc(SCC2=C(C(=O)O)N3C(=O)[C@@H](N)[C@H]3SC2)s1,,O,,O=C([O-])O.[Na+],,val
US20100029782A1,CCOC(=O)C(C)(C)c1cc(F)c(F)c(OCc2ccccc2)c1>>CCOC(=O)C(C)(C)c1cc(O)c(F)c(F)c1,,CCO,,,,val
US20140315923A1,Cc1nc(N2CC[C@H](N3CCC[C@@H]3C)C2)ccc1N1CCC2(CCN(C(=O)OC(C)(C)C)CC2)C1=O>>Cc1nc(N2CC[C@H](N3CCC[C@@H]3C)C2)ccc1N1CCC2(CCNCC2)C1=O,,C1COCCO1,,Cl,,val
US20130004836A1,O=[N+]([O-])O.O=c1c(=O)c2cccc3c2-c2c1cccc2c(=O)c3=O>>O=c1c(=O)c2cc([N+](=O)[O-])cc3c2-c2c1cccc2c(=O)c3=O,,O,,,,val
US20100292236A1,NCC1(c2cccnc2)CCCCC1.O=C(O)c1cn(-c2ncccn2)nc1Cl>>O=C(NCC1(c2cccnc2)CCCCC1)c1cn(-c2ncccn2)nc1Cl,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20030069230A1,CC(C)(C)OC(=O)N1CCc2c(cccc2C(=N)N2CCOCC2)C1>>N=C(c1cccc2c1CCNC2)N1CCOCC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20070082872A1,COc1ccc(C=O)cc1O[Si](C)(C)C(C)(C)C.[Li]C>>COc1ccc(C(C)O)cc1O[Si](C)(C)C(C)(C)C,,CCOCC,,,,val
US20060100229A1,CCCCn1nc(C(=O)OCC)cc1CCS(=O)(=O)CCC>>CCCCn1nc(C(=O)O)cc1CCS(=O)(=O)CCC,,CCO,,[Na+].[OH-],,val
US20150175599A1,Cc1cc2cc(C(=O)O)ccc2n1Cc1ccc(Cl)cc1>>Cc1cc2cc(CO)ccc2n1Cc1ccc(Cl)cc1,,C1CCOC1,,,,val
US20120082702A1,CN1CCC(C)(c2ccc(N)cc2)CC1.NC(=O)c1cc(F)c(Cl)nc1Cl>>CN1CCC(C)(c2ccc(Nc3nc(Cl)c(F)cc3C(N)=O)cc2)CC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05861359,CC(C)(C)Oc1ccc(-c2noc(C(F)(F)F)c2Cl)c(F)c1>>Oc1ccc(-c2noc(C(F)(F)F)c2Cl)c(F)c1,,ClCCl,,BrB(Br)Br,,val
US05102877,CC(C)(C)OC(=O)N1CC[C@H](OC(=O)c2ccccc2)C1>>CC(C)(C)OC(=O)N1CC[C@H](O)C1,,CO,,CC(=O)O,C[O-].[Na+],val
US05874429,ClCCCCl.O=S1(=O)NCC2(OCCO2)c2ccccc21>>O=S1(=O)c2ccccc2C2(CN1CCCCl)OCCO2,,CN(C)C=O,,[H-].[Na+],,val
US20070167443A1,C1CCNC1.O=C(c1ccc(Cl)nc1)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O>>O=C(c1ccc(N2CCCC2)nc1)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O,,C1CCOC1,,,,val
US20080188528A1,CCOC(=O)Cn1cc(C)cc(Cc2ccccc2)c1=O>>Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)O)c1,,CO,O,[Na+].[OH-],,val
US20080139631A1,O=C(Cl)c1ccccn1.[H]/N=C(/Cn1c(C(F)F)cc2c(Cl)c(C#N)ccc21)NO>>N#Cc1ccc2c(cc(C(F)F)n2Cc2noc(-c3ccccn3)n2)c1Cl,,C1CCOC1,,CCN(CC)CC,Cl,val
US20080269200A1,NC(=O)c1cc(-c2ccccc2)cc2cc[nH]c12.O=C1CCC(=O)N1Br>>NC(=O)c1cc(-c2ccccc2)cc2c(Br)c[nH]c12,,ClCCl,,,,val
US04474754,CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)NNC(=O)OC(C)(C)C>>CC(C)C[C@H](NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NNC(=O)OC(C)(C)C,[Pd],CO,,[H][H],,val
US04379785,NS(=O)(=O)c1ccc(CCNC(=O)N2CCCC2=O)cc1.O=C=NC1CCCCC1>>O=C(NC1CCCCC1)NS(=O)(=O)c1ccc(CCNC(=O)N2CCCC2=O)cc1,,CC(C)=O,,O,[Na+].[OH-],val
US06015774,COc1cc(I)c(Cl)cc1Cl.O=C[O-]>>COc1cc(C=O)c(Cl)cc1Cl,,CN(C)C=O,,Cl,,val
US20070149562A1,CC(C)(C)OC(=O)N1C2CCC1CC(CO)(c1ccccc1)C2.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1C2CCC1CC(COS(C)(=O)=O)(c1ccccc1)C2,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20140005187A1,C=CCCC(N)CCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(F)c1.O=C(O)/C=C/C(=O)O>>C=CCC(C)(N)CCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(F)c1.O=C(O)/C=C/C(=O)O,,CCO,,,,val
US20110190490A1,CC(=N)N.CCOC(=O)C(NC(=O)c1cc(F)ccc1Cl)C(=O)OCC>>Cc1nc(O)c(NC(=O)c2cc(F)ccc2Cl)c(O)n1,,CCO,,Cl,C[O-].[Na+],val
US20120027874A1,C#Cc1nc(-c2ccc(=O)n(C(C)C)c2)cnc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.ON=C(Cl)c1cccc(CCl)c1>>CC(C)n1cc(-c2cnc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(-c3cc(-c4cccc(CCl)c4)no3)n2)ccc1=O,,C1CCOC1,,CCN(CC)CC,,val
US20120088750A1,O=[N+]([O-])c1c(F)c(Br)cc(-c2ccccn2)c1I>>Nc1c(F)c(Br)cc(-c2ccccn2)c1I,[Fe],CO,,[Cl-].[NH4+],,val
US20140275080A1,Cn1cc(-c2cc(Oc3ccc(N)nc3)ccn2)cn1.NC(=O)CC1CC2CCC1C2.O=C(Cl)C(=O)Cl>>Cn1cc(-c2cc(Oc3ccc(NC(=O)NC(=O)CC4CC5CCC4C5)nc3)ccn2)cn1,,C1CCOC1,ClCCCl,c1ccncc1,,val
US20120056183A1,CC1=C(C)C(=O)OC1=O.CCO[Si](CCCN)(OCC)OCC>>CCO[Si](CCCN1C(=O)C(C)=C(C)C1=O)(OCC)OCC,,C1CCCCC1,,c1ccncc1,,val
US05977270,BrCC1CO1.C1=Cc2ccccc2C1.C1CCOC1.CCCCCC.COS(=O)(=O)OC.[Li]CCCC>>COC(CC1=CCc2ccccc21)CC1=CCc2ccccc21,,C1CCOC1,,[Cl-].[NH4+],,val
US05089513,CC[Mg]I.COc1cc(OCc2ccc3ccccc3c2)cc(C(=O)c2nccs2)c1>>CCC(O)(c1cc(OC)cc(OCc2ccc3ccccc3c2)c1)c1nccs1,,C1CCOC1,,CCOCC,[Cl-].[NH4+],val
US20120041004A1,Cc1c(N)c(=O)n(C)c(=O)n1C.O=N[O-]>>Cn1c(=O)c2[nH]ncc2n(C)c1=O,,O,,Cl,,val
US20020169188A1,CS(=O)(=O)Cl.N#Cc1ccc(-c2ccc3c(c2)CC(CCO)O3)cc1>>CS(=O)(=O)OCCC1Cc2cc(-c3ccc(C#N)cc3)ccc2O1,,ClCCl,,CCN(CC)CC,,val
US04245097,CCC1CCCN1C(=O)c1ccc(N)cc1.OCCCCCCCCCCCCCCBr>>O=C(c1ccc(NCCCCCCCCCCCCCCO)cc1)N1CCCC1,,CN(C)P(=O)(N(C)C)N(C)C,,,,val
US06303789B1,CI.COc1ccc(C#N)c2c1OC1(COCC1O)C2>>COc1ccc(C#N)c2c1OC1(COCC1OC)C2,,CN(C)C=O,,[H-].[Na+],,val
US06262045B1,CCOC(=O)C(=O)c1c(C(=O)OCC)n(C)c2cc(Cl)ccc12.NNc1ccccc1>>CCOC(=O)c1nn(-c2ccccc2)c(=O)c2c1c1ccc(Cl)cc1n2C,,CC(=O)O,,ClCCl,O,val
US20080293706A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)S(=O)(=O)c1cc(Br)cnc1N>>CN(C)S(=O)(=O)c1cc(B2OC(C)(C)C(C)(C)O2)cnc1N,,C1COCCO1,,CC(=O)[O-].[K+],,val
US05232917,CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.CC(C)C(=O)O>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](OC(=O)C(C)C)CC[C@]4(C)[C@H]3CC[C@]12C,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090209597A1,CCOC(=O)c1cn(-c2cccc(C(C)(C)O[SiH2]C(C)(C)C)c2)cn1>>CCOC(=O)c1cn(-c2cccc(CO)c2)cn1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130035341A1,C=CCBr.COC(=O)c1ccc(F)cc1O>>C=CCOc1cc(F)ccc1C(=O)OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080287434A1,CCNc1ccnc(N)c1.Cc1ccc(S(=O)(=O)ON)cc1>>CCNc1ccn(N)c(=N)c1.Cc1ccc(S(=O)(=O)O)cc1,,ClCCl,,,,val
US20150174261A1,CC(C)(C)[Si](C)(C)OCCCCO.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CC(C)(C)[Si](C)(C)OCCCCOC(=O)Oc1ccc([N+](=O)[O-])cc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20150284390A1,CC(=O)c1cc(Cl)c(C)c(Br)c1-c1cccc(F)c1.Cc1noc(C)c1B1OC(C)(C)C(C)(C)O1>>CC(=O)c1cc(Cl)c(C)c(-c2c(C)noc2C)c1-c1cccc(F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,[Na],,val
US20050222408A1,O=C(c1ccc([N+](=O)[O-])o1)N1CCNCC1.O=Cc1ccc(F)cc1>>O=C(c1ccc([N+](=O)[O-])o1)N1CCN(Cc2ccc(F)cc2)CC1,,C1CCOC1,,CC(=O)O,,val
US05298652,CCCCCCCCCCCCCCOc1ccc(C(=O)N(CC(=O)OC)CC(=O)OC)cc1OCCCCCCCCCCCCCC>>CCCCCCCCCCCCCCOc1ccc(C(=O)N(CC(=O)O)CC(=O)O)cc1OCCCCCCCCCCCCCC,,C1COCCO1,CO,[Na+].[OH-],,val
US07192967B1,O=C(C=Cc1cccnc1)NCCCCO.O=C1NC(=O)C(c2ccccc2)(c2ccccc2)N1>>NC(=O)C(=Cc1cccnc1)CCCCN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04791231,O=Cc1ccc2c(c1)CCc1cc3c(cc1-2)CCCC3>>O=Cc1ccc2c(ccc3cc4ccccc4cc32)c1,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20040063704A1,O=C(Oc1ccc(O)cc1)c1ccccc1.O=[N+]([O-])O>>O=C(Oc1ccc(O)c([N+](=O)[O-])c1)c1ccccc1,,CC(=O)O,,,,val
US20120071489A1,CC(C)(C)c1ccccc1N1CCN(C(=O)c2ccc(Cl)nc2)CC1.CCOC(=O)CS>>CCOC(=O)CSc1ccc(C(=O)N2CCN(c3ccccc3C(C)(C)C)CC2)cn1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05665522,COC(=O)CC(=O)C(C)(C)C.NO>>CC(C)(C)c1cc(=O)o[nH]1,,CCO,,Cl,O,val
US20100190747A1,CCI.O=C1Cc2c([nH]c(=S)n(-c3ccc(OCC(F)(F)F)c(F)c3)c2=O)N1>>CCSc1nc2c(c(=O)n1-c1ccc(OCC(F)(F)F)c(F)c1)CC(=O)N2,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20140065136A1,CC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.CC1(C)COc2c(nc(Cl)nc2N2CCOCC2)O1>>CC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)OCC(C)(C)O3)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20100256124A1,COc1cccc2ccc(=O)n(C)c12>>Cn1c(=O)ccc2cccc(O)c21,,Br,CC(=O)O,,,val
US20120088748A1,CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Cl)c(F)c2)[C@H](CN)C1.COCC(=O)Cl>>COCC(=O)NC[C@@H]1CN(C(=O)OC(C)(C)C)CCO[C@H]1c1ccc(Cl)c(F)c1,,C1CCOC1,,CCN(CC)CC,,val
US20110237573A1,Cc1cc(-c2ccc(CC(=O)Nc3ccc(N4CCNCC4)cn3)cc2)ccn1.N#CCBr>>Cc1cc(-c2ccc(CC(=O)Nc3ccc(N4CCN(CC#N)CC4)cn3)cc2)ccn1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05965553,CCOC(=O)C[C@H]1O[C@H](c2cccc3ccccc23)c2cc(Cl)ccc2N(CC(C)(C)CN(C)C)C1=O>>CN(C)CC(C)(C)CN1C(=O)[C@@H](CC(=O)O)O[C@H](c2cccc3ccccc23)c2cc(Cl)ccc21,,CO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US05169431,C=C(Cl)CCl.O=[N+]([O-])c1cc(O)c(Cl)cc1F>>C=C(Cl)COc1cc([N+](=O)[O-])c(F)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20020147334A1,CCOC(=O)CC(Cc1ccc(O)cc1)c1ccccn1.CNc1cccc(C(C)O)n1>>CCOC(=O)CC(Cc1ccc(OCCc2cccc(NC)n2)cc1)c1ccccn1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150005311A1,C[Si](C)(C)N=[N+]=[N-].Cc1ccc(-c2nc3c(nc2-c2ccc(C)cc2)N(CCCCCCC(=O)NCCC#N)CCC3)cc1>>Cc1ccc(-c2nc3c(nc2-c2ccc(C)cc2)N(CCCCCCc2nnnn2CCC#N)CCC3)cc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060084687A1,Clc1ccc2[nH]ccc2c1.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(c1ccccc1)n1ccc2cc(Cl)ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20160002224A1,C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@@H]3[C@H](O)CO[C@H]23)cc2nc(-c3ccc(C4(CS(C)(=O)=O)CC4)cc3)c(Cl)cc21>>CS(=O)(=O)CC1(c2ccc(-c3nc4cc(O[C@@H]5CO[C@@H]6[C@H](O)CO[C@H]56)n(CO)c4cc3Cl)cc2)CC1,,C1CCOC1,,Cl,,val
US20050119304A1,Nc1ccc2ncsc2c1.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1ccc2ncsc2c1,c1ccncc1,C1COCCO1,,,,val
US20140329812A1,CC(C)[Si](C#CN(Cc1ccc(N2CCOCC2)cc1)C(=O)OC(C)(C)C)(C(C)C)C(C)C>>C#CN(Cc1ccc(N2CCOCC2)cc1)C(=O)OC(C)(C)C,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US03931326,CC=CC(=O)C=C(C)CCC=C(C)C>>C/C=C/C(=O)C1C(C)=CCCC1(C)C,,c1ccccc1,,CCOCC,FB(F)F,val
US05536718,O=C(Cl)c1ccc(Cl)nc1.c1ccc2c(c1)Cn1nccc1CN2>>O=C(c1ccc(Cl)nc1)N1Cc2ccnn2Cc2ccccc21,,ClCCl,,CCN(CC)CC,,val
US20070167482A1,COc1cc2c(cc1OC)C1CC(OC(C)=O)CCC1N=C2c1ccc(C(=O)N=C(N)N2CCN(C(C)=O)CC2)cc1>>COc1cc2c(cc1OC)C1CC(O)CCC1N=C2c1ccc(C(=O)N=C(N)N2CCN(C(C)=O)CC2)cc1,,CO,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05234894,CCOC(=O)C(C)Oc1ccc(OC2(Cl)C=CC(C(F)(F)F)=CN2)cc1.N#CCc1cccc(C(F)(F)F)c1>>CC(Oc1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1)C(=O)C(C#N)c1cccc(C(F)(F)F)c1,,CCO,,Cl,[Na],val
US20090239854A1,C=Cc1ccc(C)nc1.Cc1ccc2[nH]c3c(c2c1)CN(c1ccc(C(F)F)cc1)CC3>>Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(c2ccc(C(F)F)cc2)C1,,CN1CCCC1=O,,[K+].[OH-],,val
US05708018,CCCN(CCC)C1Cc2ccc(Br)cc2C1.CSSC>>CCCN(CCC)C1Cc2ccc(SC)cc2C1,,CCOCC,,CCCCC,[Li]C(C)(C)C,val
US20080015187A1,COC(=O)c1n[nH]c(C(=O)OC)c1OCc1ccccc1.N#CC(Br)c1ccccc1>>COC(=O)c1nn(C(C#N)c2ccccc2)c(C(=O)OC)c1OCc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070043065A1,Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(N3CCN(C(C)C)CC3)cc2c1=O.Cc1ccc(S(=O)(=O)O)cc1>>Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(N3CCN(C(C)C)CC3)cc2c1=O.Cc1ccc(S(=O)(=O)O)cc1,,CCOC(C)=O,,,,val
US20070225292A1,COCc1ccc(C(=O)Nc2cccnc2C(=O)NCC2CCCCN2C(=O)OC(C)(C)C)c2ccccc12.O=C(O)C(F)(F)F>>COCc1ccc(C(=O)Nc2cccnc2C(=O)NCC2CCCCN2)c2ccccc12.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20120046306A1,COc1cc(OCCOC(C)=O)ccc1NC(=O)CNC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>COc1cc(OCCOC(C)=O)ccc1NC(=O)CN.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20150166573A1,CCS.N#Cc1cnccc1Cl>>CCSc1ccncc1C#N,,C1CCOC1,,[H-].[Na+],,val
US05194664,COC(=O)c1ccc(C(=O)C(=O)c2ccc3c(c2)C(C)(C)CCC3(C)C)cc1>>CC1(C)CCC(C)(C)c2cc(C(=O)C(=O)c3ccc(C(=O)O)cc3)ccc21,,O=S(=O)(O)O,,CC(=O)O,O,val
US20090130165A1,COC(=O)CCS.O=C1Cc2cc(C(=O)CCl)c(Cl)cc2N1>>COC(=O)CCSCC(=O)c1cc2c(cc1Cl)NC(=O)C2,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04178293,O=C(O)c1c(F)c(F)c(F)c(F)c1C(=O)O>>OCc1c(F)c(F)c(F)c(F)c1CO,,C1CCOC1,,B,,val
US20050070441A1,Cc1cc(O)n[nH]1.O=[N+]([O-])c1cc(C(F)(F)F)cc(Cl)c1F>>Cc1cc(Oc2c(Cl)cc(C(F)(F)F)cc2[N+](=O)[O-])n[nH]1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20060148817A1,CC(C)(C)OC(=O)N1CCN(c2c[nH]nc2-c2cc(Cl)c(OCc3ccccc3)cc2OCc2ccccc2)CC1>>CC(C)(C)OC(=O)N1CCN(c2c[nH]nc2-c2cc(Cl)c(O)cc2O)CC1,[Pd],CCOC(C)=O,,,,val
US20160207926A1,CCn1c(-c2cnc(C)nc2)nc2c(N[C@H]3CCN(C(=O)OC(C)(C)C)[C@@H]3C)ncnc21.Cl>>CCn1c(-c2cnc(C)nc2)nc2c(N[C@H]3CCN[C@@H]3C)ncnc21.Cl,,ClCCl,,C1COCCO1,,val
US20100190818A1,CCOc1cc2c(cc1OC)C(c1ccc(-n3cccn3)nc1)=N[C@@H]1CC[C@@H](OC(=O)C(=O)CCC(=O)O)C[C@H]21>>CCOc1cc2c(cc1OC)C(c1cncnc1)=N[C@@H]1CC[C@@H](OC(=O)C(=O)CCC(=O)O)C[C@H]21,,CC(C)=O,,,,val
US20100075948A1,COC(=O)C/N=C/CC(C)(C)Cc1ccc(OC)cc1.N#C/C(=C\c1cccc(Cl)c1F)c1ccc(Cl)cc1F>>COC(=O)C1NC(CC(C)(C)Cc2ccc(OC)cc2)C(C#N)(c2ccc(Cl)cc2F)C1c1cccc(Cl)c1F,,ClCCl,,CCN(CC)CC,,val
US05639770,CCOc1ccc(-c2nc(-c3cccc[n+]3[O-])cs2)cc1OCC.C[Si](C)(C)C#N>>CCOc1ccc(-c2nc(-c3cccc(C#N)n3)cs2)cc1OCC,,CC#N,,CCN(CC)CC,,val
US05719141,O=C1CCC(=O)N1Br.OCC1(COCc2ccccc2)CC1>>BrCC1(COCc2ccccc2)CC1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20160214997A1,COc1ccc(CNc2nc3c4c(ccc3c3nc(COS(C)(=O)=O)nn23)OC(F)(F)O4)c(OC)c1.c1cn[nH]c1>>COc1ccc(CNc2nc3c4c(ccc3c3nc(Cn5cccn5)nn23)OC(F)(F)O4)c(OC)c1,,CC#N,O,[I-].[K+],,val
US04181666,C=CC#N.CCOC(=O)C(C)O>>CC1OCC(C#N)C1=O,,C1CCOC1,,O,[H-].[Na+],val
US20060019961A1,CC[C@@H]1C(=O)Nc2cc(F)ccc2N1C(=O)c1ccc(OC)cc1.CI>>CC[C@@H]1C(=O)N(C)c2cc(F)ccc2N1C(=O)c1ccc(OC)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150299189A1,COC(=O)c1cc(C2CC2)cnc1N(C(=O)C(F)(F)F)c1ccc2[nH]ccc2c1.COc1cccc(CBr)c1>>COC(=O)c1cc(C2CC2)cnc1N(C(=O)C(F)(F)F)c1ccc2c(ccn2Cc2cccc(OC)c2)c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20040235822A1,O=C(c1ccc(F)cc1)c1ccc(Cl)cn1.[N-]=[N+]=[N-]>>Nc1ccc(C(O)c2ccc(Cl)cn2)cc1,,CS(C)=O,,O,,val
US20150080549A1,CC(C)(C)OC(=O)CCCCCc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N2CCCCC2)cc1.O=C(OCC1c2ccccc2-c2ccccc21)ON1C(=O)CCC1=O>>O=C(O)CCCCCc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)N2CCCCC2)cc1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US05817698,CC(C)(c1ccccc1)c1ccc(O)cc1.O=C1c2ccccc2C(=O)N1[C@H]1CCC[C@H]1CO>>CC(C)(c1ccccc1)c1ccc(OC[C@@H]2CCC[C@@H]2N2C(=O)c3ccccc3C2=O)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130237515A1,CC1(O)CCNC1.Cc1cc(CBr)ccc1C(=O)Cn1ccc(OCc2ccccc2)cc1=O>>Cc1cc(CN2CCC(C)(O)C2)ccc1C(=O)Cn1ccc(OCc2ccccc2)cc1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140127240A1,CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@]1(C(=O)N2CCCCO2)C[C@@H]1c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C.O=CCCCCCNC(=O)OCc1ccccc1>>CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@]1(C(=O)N2CCCCO2)C[C@@H]1c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCCCCCN)C(C)C,[Pd],CO,,O=C(O)C(F)(F)F,,val
US20140364413A1,CC(C)(C)OC(=O)CN(C(=O)OC(C)(C)C)c1ccc(-c2c(C#Cc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C(O)CNc1ccc(-c2c(C#Cc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1,,CCOCC,,ClCCl,,val
US20040176325A1,CC(C)Cn1ncc2cc(Oc3ccc(F)cc3)c(C(N)=O)cc21.NCCCN1CCOCC1>>CC(C)Cn1ncc2cc(Oc3ccc(F)cc3)c(C(=O)NCCCN3CCOCC3)cc21,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20060051524A1,CC(C)(Br)C(=O)Br.O=[N+]([O-])c1ccc(O)cc1>>CC(C)(Br)C(=O)Oc1ccc([N+](=O)[O-])cc1,,C1CCOC1,,CCN(CC)CC,,val
US04331674,BrBr.CCOC(=O)C(C)(C)C(=O)COc1ccc(Cl)cc1>>CCOC(=O)C(C)(C)C(=O)C(Br)Oc1ccc(Cl)cc1,,ClC(Cl)(Cl)Cl,,,,val
US20080027074A1,CC(C)(C)OC(=O)N1CCC(c2ccccc2Sc2c[nH]c3ccccc23)CC1>>c1ccc(C2CCNCC2)c(Sc2c[nH]c3ccccc23)c1,,CCOCC,,Cl,O=C([O-])O.[Na+],val
US20110294807A1,CCC(C)c1ccc(-n2c(-c3cc(C)c(OC(C)=O)c(C)c3)nc3ccncc3c2=O)cc1>>CCC(C)c1ccc(-n2c(-c3cc(C)c(O)c(C)c3)nc3ccncc3c2=O)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20160158207A1,Cn1cc(-c2ccc3c(c2)CCN3C(=O)OC(C)(C)C)c(C(F)(F)F)n1>>Cn1cc(-c2ccc3c(c2)CCN3)c(C(F)(F)F)n1,,CCOC(C)=O,,Cl,,val
US20130267510A1,CC(C)(N)C(=O)Nc1ccc(Oc2cccc3c2C(C)(C)CO3)nc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC1(C)NC(=O)N(c2ccc(Oc3cccc4c3C(C)(C)CO4)nc2)C1=O,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20140135330A1,CC(N)C(O)c1nccs1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C[C@@H]1NC(=O)O[C@H]1c1nccs1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090118292A1,COCCOc1cc(C#N)cc(-c2cn3nc(Cl)ccc3n2)c1>>COCCOc1cc(C#N)cc(-c2cn3ncccc3n2)c1,[Pd],CO,,,,val
US20130005707A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cccc(CCC2CCNCC2)n1>>CC(C)(C)OC(=O)N1CCC(CCc2cccc(N)n2)CC1,,ClCCl,,CCN(CC)CC,O,val
US06414173B1,O=C(Cl)c1ccccc1.OC1C=CCCC1>>O=C(c1ccccc1)C1C=CCCC1,,ClCCl,,c1ccncc1,,val
US20080194591A1,CCOCCn1nc(C(=O)OC)c([N+](=O)[O-])c1C(=O)OC>>CCOCCn1nc(C(=O)OC)c([N+](=O)[O-])c1C(=O)O,,CO,,[K+].[OH-],,val
US03967962,O=C(O)CCCCCCCCC(=O)O.OCCCCCCO>>O=C1CCCCCCCCC(=O)OCCCCCCO1,Cc1ccc(S(=O)(=O)O)cc1,O,,Cc1ccccc1C,,val
US20070161654A1,CCC(=O)CC(=O)OC.O/N=C(\Cl)c1ccccc1>>CCc1onc(-c2ccccc2)c1C(=O)OC,,CO,,C[O-].[Na+],,val
US04604390,CCN(CC)CCn1nc2c3c(c(N)ccc31)Sc1ccccc1-2.O=C1OCCN1CCCl>>CCN(CC)CCn1nc2c3c(c(NCCN4CCOC4=O)ccc31)Sc1ccccc1-2,,ClC(Cl)Cl,,,,val
US06610692B1,N#Cc1ccc(F)c(C=O)c1.[Li]C>>CC(O)c1cc(C#N)ccc1F,,C1CCOC1,,,,val
US20100144714A1,CC(C)CC1C(=O)N(Cc2ccc(N3CCNCC3)cc2)c2nc3ccccc3c(=O)n21.CCI.Cl>>CCN1CCN(c2ccc(CN3C(=O)C(CC(C)C)n4c3nc3ccccc3c4=O)cc2)CC1.Cl,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20090156599A1,Clc1cccc(Cl)c1Cc1nc2c(Cl)ncnc2s1.Nc1nnc(C(F)(F)F)s1>>FC(F)(F)c1nnc(Nc2ncnc3sc(Cc4c(Cl)cccc4Cl)nc23)s1,,CN(C)C=O,,O,[H-].[Na+],val
US06110924,CCCCCCCCC1(Br)C(=O)NC(=O)NC1=O.OCCN1CCNCC1>>CCCCCCCCC1(C2CNCCN2CCO)C(=O)NC(=O)NC1=O,,CS(C)=O,,O,,val
US20060025415A1,Nc1ccc(S(=O)(=O)Nc2nccs2)cc1.O=C(O)COc1ccnc2c(C(F)(F)F)cccc12>>O=C(COc1ccnc2c(C(F)(F)F)cccc12)Nc1ccc(S(=O)(=O)Nc2nccs2)cc1,,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US04567172,CCCC(=O)OC(=O)CCC.COCC(=O)O[C@]1(C(=O)CO)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C>>CCCC(=O)OCC(=O)[C@@]1(OC(=O)COC)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C,,ClCCl,,CCN(CC)CC,,val
US20100256097A1,Brc1cccc(Br)n1.CC(C)(C)OC(=O)N1CCN(C=O)CC1>>CC(C)(C)OC(=O)N1CCN(C(O)c2cccc(Br)n2)CC1,,C1CCOC1,,[Li]CCCC,,val
US05532235,CO.O=C(O)c1coc2c1C(=O)CCC2>>COC(=O)c1coc2c1C(=O)CCC2,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120252792A1,NC1CC(=O)N(c2ccc(Cl)cc2)C1.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C(NC1CC(=O)N(c2ccc(Cl)cc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,,val
US20080171748A1,CC(C)[Si](Cl)(C(C)C)C(C)C.COc1ccc([C@H]2C[C@@H](CO)N(S(=O)(=O)c3ccc(C)cc3)C[C@@H]2O)cc1>>COc1ccc([C@H]2C[C@@H](CO[Si](C(C)C)(C(C)C)C(C)C)N(S(=O)(=O)c3ccc(C)cc3)C[C@@H]2O)cc1,,CN(C)C=O,Cl,c1c[nH]cn1,,val
US20160016960A1,CC1(CO)CCNCC1.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc(C(=O)NCC(=O)Cc3ccc(F)cc3)nn2c1I>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc(C(=O)NCC(=O)Cc3ccc(F)cc3)nn2c1N1CCC(C)(CO)CC1,,CN1CCCC1=O,O,CCN(C(C)C)C(C)C,Cl,val
US20030166639A1,CC(C)(C)OC(=O)Nc1ccc(OC(F)(F)F)cc1NC(=O)CC(=O)c1cccc(-c2cccnc2)c1>>O=C1CC(c2cccc(-c3cccnc3)c2)=Nc2ccc(OC(F)(F)F)cc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04202894,CCC(C)(C)c1ccc(C=C(C)C=O)cc1>>CCC(C)(C)c1ccc(C=C(C)CO)cc1,,CO,,[BH4-].[Na+],,val
US20070123535A1,O[C@H](CCCl)c1ccccc1.c1cnc2cc[nH]c2c1>>ClCC[C@@H](c1ccccc1)n1ccc2ncccc21,,CO,,,,val
US05041232,COc1ccc(C=O)cc1.NS(=O)(=O)c1ccc(C(=O)O)cc1>>COc1ccc(C=NS(=O)(=O)c2ccc(C(=O)O)cc2)cc1,,Clc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20130261111A1,C=CCN(CC(=O)N(C)OC)C(=O)OC(C)(C)C.[Li]c1cccs1>>C=CCN(CC(=O)c1cccs1)C(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20110098324A1,CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(Cc2ccc(C)cc2C)c1=O.NC1CCCCC1>>Cc1ccc(Cn2c(O)c(C(=O)NC3CCCCC3)c(O)c(C(=O)NCC(=O)O)c2=O)c(C)c1,,ClC(Cl)Cl,,,,val
US20150087680A1,CC(C)(C)OC(=O)c1ccc(C[C@@H](C(=O)O)c2ccc(C3=CCC(C(C)(C)C)CC3)cc2)cc1>>CC(C)(C)OC(=O)c1ccc(C[C@@H](C(=O)O)c2ccc([C@H]3CC[C@@H](C(C)(C)C)CC3)cc2)cc1,[Pd],CCOC(C)=O,,[H][H],,val
US20090247512A1,CCOCOC1CC2C(=O)NC3(C(=O)OCC)CC3C=CCCCCCN(Cc3ccc(OC)cc3)C(=O)N2C1>>CCOCOC1CC2C(=O)NC3(C(=O)O)CC3C=CCCCCCN(Cc3ccc(OC)cc3)C(=O)N2C1,,CO,ClCCl,C1CCOC1,[Li+].[OH-],val
US20080280875A1,COCOc1cc(CO[Si](C)(C)C(C)(C)C)cc(OCOC)c1C/C=C/c1ccccc1>>COCOc1cc(CO)cc(OCOC)c1C/C=C/c1ccccc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160166574A1,CC(C)(C)OC(=O)NCCCn1cc([N+](=O)[O-])cn1>>CC(C)(C)OC(=O)NCCCn1cc(N)cn1,[Pd],CO,,,,val
US20070287695A1,O=C(O)c1ccccc1.O=C1N[C@@H]2CCCC[C@@H]2N1C1CCN(C2CCNCC2)CC1>>O=C(c1ccccc1)N1CCC(N2CCC(N3C(=O)N[C@@H]4CCCC[C@@H]43)CC2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110237590A1,N#CCCCBr.NC(=O)Cc1cnc(Nc2ccc(N)cc2)cc1NCc1ccccc1>>N#CCCCNc1ccc(Nc2cc(NCc3ccccc3)c(CC(N)=O)cn2)cc1,,O,,CN(C)C=O,O=C([O-])O.[Na+],val
US06303785B1,CC1(C)CC(C)(C)c2cc(Br)cc(C=O)c2O1.CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCC3NC2CC2)cc1>>C=Cc1cc(Br)cc2c1OC(C)(C)CC2(C)C,,CCCCCC,,,,val
US20100298324A1,COC(=O)c1cc(OC)c(C(=O)OC)c([N+](=O)[O-])c1>>COC(=O)c1cc(N)c(C(=O)OC)c(OC)c1,[Fe],Cc1ccccc1,,CC(=O)O,,val
US20150210644A1,CC(N)=O.Cc1ccc2nc(Cl)ccc2c1>>CC(=O)Nc1ccc2cc(C)ccc2n1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20080242706A1,BrCc1ccccc1.Cn1ccc(=O)c(O)c1C(O)C(F)(F)F>>Cn1ccc(=O)c(OCc2ccccc2)c1C(O)C(F)(F)F,,CO,O,[Na+].[OH-],,val
US20090047221A1,CC(C)=O.COC(=O)c1ccc(C)c(C(=O)OC)c1O>>COC(=O)c1ccc2c(c1O)C(=O)OC(C)(C)C2,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20110021534A1,CCOC(Cc1ccc(OC(=O)Cc2ccc(NC(=O)OC(C)(C)C)cc2)c(Cc2ccccc2)c1)C(=O)OCc1ccccc1>>CCOC(Cc1ccc(OC(=O)Cc2ccc(NC(=O)OC(C)(C)C)cc2)c(Cc2ccccc2)c1)C(=O)O,,CCOC(C)=O,,CCO,,val
US20100137361A1,Nc1cccc2c1CC(O)C(=O)N2.O=C=NCc1ccc(C(F)(F)F)cc1>>O=C(NCc1ccc(C(F)(F)F)cc1)Nc1cccc2c1CC(O)C(=O)N2,,CCOC(C)=O,,,,val
US20100029611A1,CS(=O)(=O)Cl.NCCc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1>>CS(=O)(=O)NCCc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1,,ClCCl,ClCCl,c1ccncc1,,val
US20040127494A1,CC(=O)Cl.CC(C)C[C@H](C(N)=O)N(Cc1ccc(N)cc1)S(=O)(=O)c1ccc(Cl)cc1>>CC(=O)Nc1ccc(CN([C@H](CC(C)C)C(N)=O)S(=O)(=O)c2ccc(Cl)cc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20160024004A1,C1CCOC1.C1COCCO1.CCN(CC)CC.CN(C)C=O.ClCCl.c1ccncc1>>CC(Cl)Cl.CCN(C(C)C)C(C)C.Cc1cccc(C)n1,,C1COCCO1,CN(C)C=O,,,val
US20090163488A1,Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc(Oc2cccc([N+](=O)[O-])c2)cn1>>Cc1ccc(S(=O)(=O)Nc2ccc(Oc3cccc([N+](=O)[O-])c3)cn2)cc1,,O,,c1ccncc1,,val
US20130190330A1,N.O=C(O)c1ccc(-c2cccc(Cl)c2Cl)cc1Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O>>NC(=O)c1ccc(-c2cccc(Cl)c2Cl)cc1Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O,,CN(C)C=O,O,ClCCCl,On1nnc2ccccc21,val
US20120122710A1,BrCCc1c[nH]c2ccccc12.O=S(=O)(NCCc1ccccc1)c1cccc2ccccc12>>O=S(=O)(c1cccc2ccccc12)N(CCc1ccccc1)CCc1c[nH]c2ccccc12,,CN(C)C=O,,[H-].[Na+],,val
US20130034616A1,CC(C)S(=O)(=O)c1ccc(-c2cnc3c(n2)c(N2Cc4cc(Br)ccc4C2=O)cn3C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CC(C)S(=O)(=O)c1ccc(-c2cnc3[nH]cc(N4Cc5cc(Br)ccc5C4=O)c3n2)cc1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20040242884A1,COCCOCc1c(C=O)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12>>COCCOCc1c(CO)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060241302A1,Fc1ccc(F)c(C(Sc2ccc(Cl)cc2)c2cc(Cl)ncc2Cl)c1.NCCc1ccccn1>>Fc1ccc(F)c(C(Sc2ccc(Cl)cc2)c2cc(NCCc3ccccn3)ncc2Cl)c1,,C1COCCO1,,,,val
US20030195216A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCCCN1CCN2CCCCC2C1>>Cc1ccc(S(=O)(=O)OCCCN2CCN3CCCCC3C2)cc1,,ClCCl,,c1ccncc1,,val
US04036983,O=C(Cl)CCCl.[Fe+2].c1cc[cH-]c1.c1cc[cH-]c1>>O=C(CCCl)[c-]1cccc1.[Fe+2].c1cc[cH-]c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20150218096A1,COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C#CCNC(=O)OC(C)(C)C)ccc23)c(F)c1>>COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C#CCN)ccc23)c(F)c1,,C1CCOC1,O,O=C(O)C(F)(F)F,,val
US20090124598A1,COC(=O)c1ccc(COC2CCCCO2)cc1>>O=C(O)c1ccc(COC2CCCCO2)cc1,,CCO,,[Na+].[OH-],,val
US20110110889A1,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3c(c2)cc(C2=CCN(C(=O)OC(C)(C)C)CC2)n3S(=O)(=O)c2ccccc2)c1F>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3c(c2)cc(C2=CCNCC2)n3S(=O)(=O)c2ccccc2)c1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030105148A1,COC(=O)C=Cc1ccc(C2=C(c3ccccc3)CCCc3ccccc32)cc1>>O=C(O)C=Cc1ccc(C2=C(c3ccccc3)CCCc3ccccc32)cc1,,C1CCOC1,CO,[K+].[OH-],,val
US20030225141A1,CN(C)C=NC(=S)NCCCNC(=O)OC(C)(C)C.Cc1ccccc1C(=O)CBr>>Cc1ccccc1C(=O)c1cnc(NCCCNC(=O)OC(C)(C)C)s1,,CCO,,CCN(CC)CC,,val
US20150376212A1,Fc1ccccc1Br.OCC1CCSCC1>>Brc1ccccc1OCC1CCSCC1,,CN(C)C=O,,[H-].[Na+],,val
US20090163464A1,C1CCN([C@@H]2CCNC2)CC1.CCNC(=O)c1ccc2[nH]c(=S)oc2c1>>CCNC(=O)c1ccc2nc(N3CC[C@@H](N4CCCCC4)C3)oc2c1,,Cc1ccccc1,ClCCl,Cl,Cl,val
US20110275611A1,N#Cc1ccc(-c2cc(N3CCOC(c4nc5cc(Cl)ccc5[nH]4)C3)nc(N)n2)cc1F.NN>>Nc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2CCOC(c3nc4cc(Cl)ccc4[nH]3)C2)n1,,CCO,,O,,val
US20060069109A1,Cc1ccnc(NC(=O)C(C)(C)C)n1.O=Cc1c(-c2ccccc2)nc2sccn12>>CC(C)(C)C(=O)Nc1nccc(/C=C/c2c(-c3ccccc3)nc3sccn23)n1,,C1CCOC1,O,Cl,CC(C)[N-]C(C)C.[Li+],val
US05629325,CN1CCC[C@H]1COc1cncc(Br)c1.OB(O)c1cnc2ccccc2c1>>CN1CCC[C@H]1COc1cncc(-c2cnc3ccccc3c2)c1,,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US04002647,CC(C)CC(C)CC(C)O.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC(C)CC(C)CC(C)C)cc1,,c1ccncc1,,,,val
US05705499,C=Cc1ccncc1.CCN1c2ncc(Br)cc2C(=O)N(C)c2ccc(F)nc21>>CCN1c2ncc(CCc3ccncc3)cc2C(=O)N(C)c2ccc(F)nc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,CCN(C(C)C)C(C)C,,val
US05298652,CCCCCCCCCCOc1cc(OCCCCCCCCCC)cc(C(=O)C(=O)O)c1.CCOC(=O)CNCC(=O)OCC>>CCCCCCCCCCOc1cc(OCCCCCCCCCC)cc(C(=O)C(=O)N(CC(=O)OCC)CC(=O)OCC)c1,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US04540690,NC1CCCCC1=Cc1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(NC1CCCC/C1=C\c1ccccc1)C(F)(F)F,,CCOCC,,[Na+].[OH-],,val
US20030083333A1,CC(C)(C)OC(=O)Nc1ccc(Oc2ccoc(=O)c2)c2ccccc12.Cl>>Cl.Nc1ccc(Oc2ccoc(=O)c2)c2ccccc12,,C1COCCO1,CCOCC,,,val
US20150218096A1,C=Cc1cccc(Cl)c1C(=O)OC>>C=Cc1cccc(Cl)c1C(=O)O,,CCO,O,Cl,[Na+].[OH-],val
US05120348,CC(Br)C(=O)Cl.OCC1CCCO1>>CC(Br)C(=O)OCC1CCCO1,,CCOCC,,CCN(CC)CC,,val
US20110118245A1,CC(C)(C#N)C(=O)CC#N.NNc1ccccc1>>CC(C)(C#N)c1cc(N)n(-c2ccccc2)n1,,CCO,,Cl,,val
US20120142671A1,CCCC[Sn](CCCC)(CCCC)c1nccs1.Nc1cccc(I)c1>>Nc1cccc(-c2nccs2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20140073589A1,CC(=O)OC[C@H]1O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.OCc1ccccc1>>CC(=O)OC[C@H]1O[C@@H](OCc2ccccc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,ClCCl,,FB(F)F,,val
US20040023973A1,CI.N#Cc1ccccc1-c1cc(-c2nc3cnccc3[nH]2)cn(-c2ccccc2)c1=O>>Cn1cccc2nc(-c3cc(-c4ccccc4C#N)c(=O)n(-c4ccccc4)c3)nc1-2,,CC(C)=O,,,,val
US20160096827A1,N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1F.OCC1CCOCC1>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1OCC1CCOCC1,,CC1CCCO1,,CC(C)(C)[O-].[K+],,val
US20070219236A1,COc1ccc2nc(SCc3nccc(OC)c3OC)[nH]c2n1.O=C(OO)c1cccc(Cl)c1>>COc1ccc2nc(S(=O)Cc3nccc(OC)c3OC)[nH]c2n1,,ClCCl,,,,val
US20080188528A1,Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](N)C(=O)OC(C)(C)C)c(C)c2c1OC(C)(C)CC2.O=C(O)c1cccn(Cc2ccc(Br)cc2)c1=O>>Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)c2cccn(Cc3ccc(Br)cc3)c2=O)C(=O)OC(C)(C)C)c(C)c2c1OC(C)(C)CC2,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150158826A1,C1COCCN1.CC(C)(C)C(=O)Nc1cccc(C(=O)c2ccc3ncc(Cl)nc3c2)c1>>CC(C)(C)C(=O)Nc1cccc(C(=O)c2ccc3ncc(N4CCOCC4)nc3c2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100022589A1,O=C(CSc1ncccc1C(=O)NC1CCCCC1)c1ccccc1>>O=C(NC1CCCCC1)c1cccnc1SCC(O)c1ccccc1,,CCO,,O,[BH4-].[Na+],val
US20110144106A1,O=C1N(c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)c2ccccc2[C@]12C[C@H]2c1ccc(Cl)cc1>>O=C1N(c2c[nH]cn2)c2ccccc2[C@]12C[C@H]2c1ccc(Cl)cc1,,ClCCl,O,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20050119295A1,CC(C)(C)OC(=O)N1CCc2c(-c3ccc(Cl)cc3)nn(Cc3ccc([N+](=O)[O-])cc3)c2CC1>>CC(C)(C)OC(=O)N1CCc2c(-c3ccccc3)nn(Cc3ccc(N)cc3)c2CC1,[Pd],CCO,,[H][H],,val
US20100076029A1,COc1ccc(CN(CC(C)(C)c2cc(NC(=O)C(C)(C)S(=O)(=O)C3CCOCC3)on2)C(C)=O)cc1>>CC(=O)NCC(C)(C)c1cc(NC(=O)C(C)(C)S(=O)(=O)C2CCOCC2)on1,,O,,CC#N,,val
US20070203218A1,CC(C)S(=O)(=O)NC1Cc2ccc(-c3cccc(CN)c3)cc2C1.CS(=O)(=O)Cl>>CC(C)S(=O)(=O)NC1Cc2ccc(-c3cccc(CNS(C)(=O)=O)c3)cc2C1,,ClCCl,,CCN(CC)CC,,val
US20110224225A1,CC(=O)O.CC(=O)OC(C)=O.COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CC[C@@H](N)C2)ncn1>>COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CC[C@@H](NC(C)=O)C2)c1,,ClCCl,,O,,val
US20130072487A1,CCOC(=O)C(C(=O)NCc1ccccc1)C(=O)OCC.O=C=Nc1ccccc1>>CCOC(=O)c1c(O)n(-c2ccccc2)c(=O)n(Cc2ccccc2)c1=O,,C1COCCO1,ClCCl,[H-].[Na+],,val
US20120270892A1,COC(=O)c1cc(Cl)nc(Cl)n1.OB(O)c1cccc(OC(F)(F)F)c1>>COC(=O)c1cc(-c2cccc(OC(F)(F)F)c2)nc(Cl)n1,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US05635510,Cl.O=C([NH2+][O-])C1(c2ccc(F)cc2)CCN(Cc2ccccc2)CC1>>Cl.NC(=O)C1(c2ccc(F)cc2)CCNCC1,[Pd],CCOC(C)=O,,CC(=O)O,[H][H],val
US20120046267A1,COCc1nc2ccc(N)cc2s1.ClI>>COCc1nc2ccc(N)c(I)c2s1,,Cl,O,O=C([O-])O.[Na+],,val
US20020165241A1,O=C(OCc1ccccc1)N1CCC(CNc2ccc(Cl)nn2)CC1>>O=C(OCc1ccccc1)N1CCC(CNc2cccnn2)CC1,[Ni],CCO,,[H][H],,val
US20140005213A1,COCCBr.Cc1ccc2ccc(O)c(C)c2n1>>COCCOc1ccc2ccc(C)nc2c1C,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110082181A1,CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1C(O)C(F)(F)/C=C/c1ccc(F)cc1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4C(O)C(F)(F)/C=C/c4ccc(F)cc4)cc3)cc2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,,,val
US20120065196A1,CON(C)C(=O)C1CCN(C(=O)OC(C)(C)C)C1.[Li]c1ccccc1>>CC(C)(C)OC(=O)N1CCC(C(=O)c2ccccc2)C1,,C1CCOC1,,,,val
US20130216552A1,CC(=O)CC(C)=O.Cc1ccc(S(=O)(=O)OCc2ccccc2S(=O)(=O)N2CCCC2)cc1>>CC(=O)CCc1ccccc1S(=O)(=O)N1CCCC1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US05516774,O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C(c1ccc([N+](=O)[O-])cc1)N1Cc2cccn2Cc2ccccc21>>O=C(c1ccc([N+](=O)[O-])cc1)N1Cc2ccc(C(=O)C(F)(F)F)n2Cc2ccccc21,,ClCCl,,,,val
US20150197526A1,Clc1cc(-c2ccco2)nc2cc(-c3ccccc3)nn12.O=C(c1ccoc1)N1CCNCC1>>O=C(c1ccoc1)N1CCN(c2cc(-c3ccco3)nc3cc(-c4ccccc4)nn23)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20030072964A1,Cc1cc2ccccc2nc1Cl.OB(O)c1ccccc1>>Cc1cc2ccccc2nc1-c1ccccc1,,COCCOC,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])[O-].[K+].[K+],val
US05141945,Cc1c2n(c3ccc(Cl)cc13)C(=O)C(C(O)c1ncn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c1C)CC2>>Cc1[nH]cnc1C(O)C1CCc2c(C)c3cc(Cl)ccc3n2C1=O,,CC(=O)O,O,,,val
US05236952,Nc1ccccn1.O=C(CBr)c1cc(O)c(O)c([N+](=O)[O-])c1>>O=[N+]([O-])c1cc(-c2cnc3ccccn23)cc(O)c1O,,CCO,,,,val
US20070037836A1,CN(C)c1nc(NC[C@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)nc2ccccc12>>CN(C)c1nc(NC[C@@H]2CC[C@H](N)CC2)nc2ccccc12,,ClCCl,O=C(O)C(F)(F)F,,,val
US20140235667A1,Cc1ccc(S(=O)(=O)C#N)cc1.Fc1ccc2nc(Cl)c(I)n2c1>>N#Cc1c(Cl)nc2ccc(F)cn12,,C1CCOC1,,[Li]CCCC,,val
US05670656,BrB(Br)Br.FC(F)(F)c1cccc(Nc2ccccc2)c1.O=C1OCCC1O>>O=C(Nc1cccc(C(F)(F)F)c1)C(O)CCBr,,ClCCCl,,O,,val
US05620997,Cc1ccnc(N)c1.O=C(Cl)c1ccccc1SCl>>Cc1ccnc(-n2sc3ccccc3c2=O)c1,,c1ccncc1,,,,val
US20160060257A1,CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)C1.Cc1ccc(S(=O)(=O)n2c(I)cc3c(Cl)ccnc32)cc1>>Cc1ccc(S(=O)(=O)n2c(C3=CCN(C(=O)OC(C)(C)C)C3)cc3c(Cl)ccnc32)cc1,,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20040014971A1,COC(=O)C(c1ccccc1)C1CCN(c2ccc(N)cc2)CC1.O=C(O)c1ccccc1-c1ccc(C(F)(F)F)cc1>>COC(=O)C(c1ccccc1)C1CCN(c2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)CC1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US05744488,COC(=O)CCn1cc(Cc2cccnc2)c2cc(CCN)ccc21.O=S(=O)(Cl)c1ccc(F)cc1>>COC(=O)CCn1cc(Cc2cccnc2)c2cc(CCNS(=O)(=O)c3ccc(F)cc3)ccc21,,ClCCl,,CCN(CC)CC,,val
US04999378,COC(=O)c1ccc(OCCCN(C(=O)CCC(=O)O)c2ccc(Cl)cc2)cc1>>O=C(O)CCC(=O)N(CCCOc1ccc(C(=O)O)cc1)c1ccc(Cl)cc1,,CO,,Cl,[Na+].[OH-],val
US20040122057A1,CCOC(C(=O)NCc1ccc(C#N)cc1)c1c(F)cc(-c2ccccc2O)cc1F.NC(=O)CI.NO>>CCOC(C(=O)NCc1ccc(C(=N)NO)cc1)c1c(F)cc(-c2ccccc2OCC(N)=O)cc1F,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20150111885A1,CS(=O)O[Na].Oc1ccc(Cl)nc1>>CS(=O)(=O)c1ccc(O)cn1,[Cu]I,CS(C)=O,O,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US20090099175A1,CC(=O)Cl.CCc1ccc(N)cc1OC>>CCc1ccc(NC(C)=O)cc1OC,,ClCCl,,CCN(CC)CC,,val
US20080015177A1,COC(=O)c1ccc(NC(=O)NCCCl)cc1>>COC(=O)c1ccc(N2CCNC2=O)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130059832A1,C=CC[Mg]Cl.O=CCOCc1ccccc1>>C=CCC(O)COCc1ccccc1,,C1CCOC1,,,,val
US20150353529A1,COC(=O)N[C@@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3cc(-c4ccc5c(c4)CCc4nc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)C6CCOCC6)[nH]c4-5)ccc3c2)[nH]1)c1ccccc1>>COC(=O)N[C@@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3cc(-c4ccc5c(ccc6nc([C@@H]7CCCN7C(=O)[C@@H](NC(=O)OC)C7CCOCC7)[nH]c65)c4)ccc3c2)[nH]1)c1ccccc1,O=[Mn]=O,CO,ClCCl,,,val
US20100204206A1,c1ccc(-c2csc(C3(OCC4CC4)CCC4(CC3)OCCO4)n2)cc1>>O=C1CCC(OCC2CC2)(c2nc(-c3ccccc3)cs2)CC1,,CC(C)=O,O,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20090318385A1,CCOC(=O)c1ccc(OC)n2nc(CC)cc12>>CCc1cc2c(C(=O)O)ccc(OC)n2n1,,CO,,[K+].[OH-],,val
US20120077793A1,CC(C)OC(=O)N1CCC(COS(C)(=O)=O)CC1.Oc1ccc(Br)cc1>>CC(C)OC(=O)N1CCC(COc2ccc(Br)cc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120088770A1,NCC1(C(=O)NO[C@@H](Cc2ccc(OCc3ccccc3)cc2)C(=O)OCc2ccccc2)CCCCC1.O=C=NCc1ccccc1>>O=C(NCc1ccccc1)NCC1(C(=O)NO[C@@H](Cc2ccc(OCc3ccccc3)cc2)C(=O)OCc2ccccc2)CCCCC1,,ClCCl,,CCN(CC)CC,,val
US05532240,Cc1cc2c(s1)CCCC(=O)N2.O=C(Cl)CCCl>>Cc1sc2c(c1C(=O)CCCl)NC(=O)CCC2,,CC(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04556666,CC(C)(C)OC(=O)C(=CC1C(C(=O)[O-])C1(C)C)OC(C)(C)C>>CC(C)(C)OC(=O)C(=CC1C(C(=O)O)C1(C)C)OC(C)(C)C,,O,,CO,Cl,val
US20050214287A1,CN1CCCC1CCN.Cn1c(C=O)nc2ccccc21>>CN1CCCC1CCNCc1nc2ccccc2n1C,,ClCCl,,[Na],,val
US20120040957A1,COc1ccc2ncc(Cl)nc2c1.OCCS>>COc1ccc2ncc(SCCO)nc2c1,,CCCCCC,CN(C)C=O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US05741785,CCOC(=O)c1ncn(-c2ccc(C(F)(F)F)cc2N)c1C.O=C(n1ccnc1)n1ccnc1>>CCOC(=O)c1nc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n2c1C,,Clc1ccccc1Cl,,,,val
US20140100231A1,COc1nc(S(C)(=O)=O)ncc1CO>>COc1ncncc1CO,,CCO,,[BH4-].[Na+],,val
US20080076745A1,CC(C)(C)OC(=O)NCCC[C@H](NC(=O)OCc1ccccc1)C(=O)NCCNC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NCCC[C@H](N)C(=O)NCCNC(=O)OC(C)(C)C,[Pd],CCO,,,,val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2ccc(N)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21.O=C(Cl)C1CC1>>CC(C)(C)OC(=O)n1c(-c2ccc(NC(=O)C3CC3)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21,,CCOC(C)=O,,CCN(CC)CC,O,val
US20100273767A1,COC(=O)CC1CN(Cc2ccccc2)CCN1c1cc(Cl)ccc1[N+](=O)[O-]>>O=C1CC2CN(Cc3ccccc3)CCN2c2cc(Cl)ccc2N1,[Fe],CC(=O)O,,,,val
US20110152287A1,COc1ccc(NC(=O)c2ccc3nc(NCCN(C)C(=O)OC(C)(C)C)sc3c2)cc1OC>>CNCCNc1nc2ccc(C(=O)Nc3ccc(OC)c(OC)c3)cc2s1,,C1COCCO1,,Cl,,val
US05281608,Clc1ccc2c(c1)ncc1c3c([nH]c12)CCNC3.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)N1CCc2[nH]c3c(cnc4cc(Cl)ccc43)c2C1,,C1CCOC1,,,,val
US04048311,CC(C)(C)OC(=O)C1=C(C(CCS(N)(=O)=O)Sc2nnn[nH]2)CS[C@@H]2C(NC(=O)CS(=O)(=O)CC(F)(F)F)C(=O)N12>>NS(=O)(=O)CCC(Sc1nnn[nH]1)C1=C(C(=O)O)N2C(=O)C(NC(=O)CS(=O)(=O)CC(F)(F)F)[C@H]2SC1,,CC#N,,O=C(O)C(F)(F)F,,val
US05112988,CN(C)c1ccccc1CC(=O)O.O=C1CCC(c2ccccc2F)(c2ccccc2F)C2CNCC12>>CN(C)c1ccccc1CC(=O)N1CC2C(=O)CCC(c3ccccc3F)(c3ccccc3F)C2C1,,ClCCl,,CCN(CC)CC,Cl,val
US20050038035A1,Cc1nc(CCN(C(=O)OC(C)(C)C)c2ccc(NC(=O)c3cccc(C)c3-c3ccc(C(F)(F)F)cc3)cc2)cs1>>Cc1nc(CCNc2ccc(NC(=O)c3cccc(C)c3-c3ccc(C(F)(F)F)cc3)cc2)cs1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090118292A1,N#Cc1cccc(-c2cn3ncccc3n2)c1.NO.O=C(Cl)CCl>>ClCc1nc(-c2cccc(-c3cn4ncccc4n3)c2)no1,,CCO,Cc1ccccc1,CCN(CC)CC,Cl,val
US20150225406A1,Br.C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12>>Br.C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12,,CC(C)=O,,,,val
US20140024650A1,CC(C)(C)OC(=O)NC1CCOCC1COc1ccc(-n2cc(Cl)cn2)cc1F.Cl>>Cl.NC1CCOCC1COc1ccc(-n2cc(Cl)cn2)cc1F,,CCOC(C)=O,,CCO,,val
US20150284411A1,C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@@H]3[C@H](OCC=O)CO[C@H]23)nc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc21>>C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@@H]3[C@H](OCCO)CO[C@H]23)nc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc21,,CO,,[BH4-].[Na+],,val
US20130184286A1,CCC(=O)Cl.Nc1ccccc1C(=O)O>>CCc1nc2ccccc2c(=O)o1,,ClCCl,,Cl,,val
US20110046127A1,CCOC(=O)c1cccc(NC(=O)c2cnc3c(C)cc(NCc4ccc(OC)cc4)nn23)c1>>COc1ccc(CNc2cc(C)c3ncc(C(=O)Nc4cccc(C(=O)O)c4)n3n2)cc1,,CCO,,[K+].[OH-],,val
US20050137201A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C(Nc1cccc(F)c1F)c1c[nH]c2ncc(Br)cc12>>Fc1cccc(NC(=S)c2c[nH]c3ncc(Br)cc23)c1F,,Cc1ccccc1,,,,val
US20080146566A1,C=CCBr.Cc1ccc(C(=O)NC2CC2)cc1N>>C=CCNc1cc(C(=O)NC2CC2)ccc1C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160257652A1,CCOC(=O)[C@H]1[C@@H]2Cc3cc(OCc4cc(Br)c(C(F)(F)F)cc4F)ncc3[C@H]12.OB(O)c1cc(F)c(O)c(F)c1>>CCOC(=O)[C@H]1[C@@H]2Cc3cc(OCc4cc(-c5cc(F)c(O)c(F)c5)c(C(F)(F)F)cc4F)ncc3[C@H]12,,C1CCOC1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20150225367A1,CNc1ccc(-c2c[nH]c3cc(F)ccc23)cn1.CS(=O)(=O)Cl>>CN(c1ccc(-c2c[nH]c3cc(F)ccc23)cn1)S(C)(=O)=O,,c1ccncc1,,,,val
US20040077662A1,CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=N)NCc1ccccc1.CC=C(C(=O)OC)C(=O)OC>>COC(=O)C1C(=O)N(Cc2ccccc2)C(C(NC(=O)OC(C)(C)C)C(C)C)=NC1C,,CO,,,,val
US20090099200A1,FC(F)(F)c1ccccc1OC1CCN(c2ncc(Br)s2)CC1.N#C[Cu]>>N#Cc1cnc(N2CCC(Oc3ccccc3C(F)(F)F)CC2)s1,,CN(C)C=O,O,,,val
US04478839,O=C=NCCCl.O=c1ncc(Cl)c[nH]1>>O=C(NCCCl)n1cc(Cl)cnc1=O,,CN(C)C=O,,,,val
US05202344,CCOC(=O)C1CN(c2ccccc2)C(=O)C1N.O=C=Nc1ccc(Cl)c(Cl)c1>>CCOC(=O)[C@@H]1CN(c2ccccc2)C(=O)[C@@H]1NC(=O)Nc1ccc(Cl)c(Cl)c1,,ClCCl,,,,val
US20020099068A1,OC1NC=Cc2c1[nH]c1cc(C(F)(F)F)ccc21>>Oc1nccc2c1[nH]c1cc(C(F)(F)F)ccc12,[Pd],,,,,val
US20130005707A1,CC(C)(C)C(=O)Nc1cccc(C=O)n1.NO>>CC(C)(C)C(=O)Nc1cccc(C=NO)n1,,CCO,O,Cl,[Na+].[OH-],val
US20070135594A1,BrBr.CC(C)c1cccc(C(C)C)c1N>>CC(C)c1cc(Br)cc(C(C)C)c1N,,CC(=O)O,,,,val
US20150065464A1,Cc1cc(C=C2CCC3(CC2)OCCO3)cc(Oc2ccc(C(F)(F)F)cn2)c1>>Cc1cc(C=C2CCC(=O)CC2)cc(Oc2ccc(C(F)(F)F)cn2)c1,,CC(C)=O,,Cl,,val
US20070129544A1,CCOC(=O)Cl.N#Cc1ccc(N)c(CO)c1>>N#Cc1ccc2c(c1)COC(=O)N2,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20140171408A1,C1COCCO1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Clc1cc(I)cc(Cl)c1-c1nc2ccnc(Cl)c2s1>>C=Cc1cc(Cl)c(-c2nc3ccnc(Cl)c3s2)c(Cl)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,O=C([O-])[O-].[Na+].[Na+],,val
US06784192B2,CC(C)(C)OC(=O)N1CCC(COc2ccccc2CCC2CCCCC2)CC1>>c1ccc(OCC2CCNCC2)c(CCC2CCCCC2)c1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],val
US20090291992A1,CC1(COS(=O)(=O)C(F)(F)F)CCCCC1.O=C1NC(=O)C(=Cc2ccc(O)cc2)S1>>CC1(CN2C(=O)SC(=Cc3ccc(O)cc3)C2=O)CCCCC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070191309A1,COc1ccc2c(c1)C(=O)N1CCC(OCCCCCCCCOC3CCN4C(=O)c5cc(OC)ccc5N(C(=O)OC(C)(C)C)[C@@H](OC5CCCCO5)[C@H]34)[C@H]1[C@H](OC1CCCCO1)N2C(=O)OC(C)(C)C>>COc1ccc2c(c1)C(=O)N1CCC(OCCCCCCCCOC3CCN4C(=O)c5cc(OC)ccc5N=C[C@@H]34)[C@@H]1C=N2,,CO,ClC(Cl)Cl,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20100249119A1,CC(C)(C#N)c1cccc(C(=O)Nc2ccc(Cl)c(Oc3ccc4nc(N)sc4n3)c2)c1.O=C(Cl)CCl>>CC(C)(C#N)c1cccc(C(=O)Nc2ccc(Cl)c(Oc3ccc4nc(NC(=O)CCl)sc4n3)c2)c1,,CC(=O)N(C)C,CCOC(C)=O,,,val
US05854234,COC1=N[C@H](C(C)C)CC[C@@H](C)C1.[Cl-].[NH4+]>>CC(C)[C@@H]1CC[C@@H](C)CC(=N)N1.Cl,,CO,,,,val
US20100144760A1,Cc1ccc(-c2ncccn2)c(C(=O)N2C[C@@H]3C[C@@H]3C[C@H]2CN)n1.Fc1cc(C(F)(F)F)cnc1F>>Cc1ccc(-c2ncccn2)c(C(=O)N2C[C@@H]3C[C@@H]3C[C@H]2CNc2ncc(C(F)(F)F)cc2F)n1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20090312370A1,C=CCCCBr.COC(=O)c1cc(O)cc(C(=O)OC)c1>>C=CCCCOc1cc(C(=O)OC)cc(C(=O)OC)c1,,CC(C)=O,ClCCl,Cl,O=C([O-])[O-].[K+].[K+],val
US20020115680A1,CN1[C@@H]2CC=C[C@@]1(OC(=O)C(O)(c1ccc(F)c(F)c1)c1ccc(F)c(F)c1)CC2.COCCS(N)(F)(F)(F)CCOC.O>>CN1[C@@H]2CC=C[C@@]1(O)CC2.O=C([O-])C(F)(c1ccc(F)c(F)c1)c1ccc(F)c(F)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US20150322039A1,CC(=O)Cl.C[C@@H]1CC[C@@H](Nc2cc(C#N)ccn2)CN1C(=O)c1ccccc1-n1nccn1>>CC(=O)N(c1cc(C#N)ccn1)[C@@H]1CC[C@@H](C)N(C(=O)c2ccccc2-n2nccn2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20050176775A1,Cc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1Cc1ccc2[nH]ccc2c1>>Cc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1Cc1ccc2c(c1)CCN2,,CC(=O)O,,O,[BH3-]C#N.[Na+],val
US05958944,O=C(NCc1ccc(C(=O)O)c(OCc2ccccc2)c1)OCc1ccccc1.O=S(Cl)Cl>>O=C(NCc1ccc(C(=O)Cl)c(OCc2ccccc2)c1)OCc1ccccc1,CN(C)C=O,ClCCl,,,,val
US20100179137A1,COC(=O)c1ccc(CCn2c(C)cccc2=O)cc1.O=C1CCC(=O)N1Br>>COC(=O)c1ccc(CCn2c(C)ccc(Br)c2=O)cc1,,CC(=O)O,,CCOC(C)=O,O,val
US20140275043A1,CC(C)(C)OC(=O)NCC[C@@H](O)c1cccc(OCC2CCCO2)c1>>NCC[C@@H](O)c1cccc(OCC2CCCO2)c1,,ClCCl,,C1COCCO1,Cl,val
US20130281490A1,CC[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C(=O)[O-]>>CC[C@H](O)[C@@H](N)C(=O)O,,Cl,,,,val
US05102890,CC(=O)N1CCC(C(=O)O)CC1.O=C1c2ccccc2C(Cl)N1c1ccc2ccc(Cl)nc2n1>>CC(=O)N1CCC(C(=O)OC2c3ccccc3C(=O)N2c2ccc3ccc(Cl)nc3n2)CC1,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US04220798,COC(=O)CCCCCC[C@H]1C2OCCOC2C[C@@H]1CCC(=O)C(C)(C)CC=C(C)C>>COC(=O)CCCCCC[C@H]1C(=O)CC[C@@H]1CCC(O)C(C)(C)CC=C(C)C,,CO,O,[BH4-].[Na+],,val
US20150218170A1,COc1ncc(Nc2cnc3c(n2)c(C(=O)NC(C)(C)C)cn3COCC[Si](C)(C)C)cn1>>COc1ncc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110034689A1,CN(C)C=Nc1ccc(NC(=S)NC(C)(C)CO)cc1C#N.Cc1nc2cc(Oc3ccc(N)cc3C)ccc2o1>>Cc1nc2cc(Oc3ccc(Nc4ncnc5ccc(NC(=S)NC(C)(C)CO)cc45)cc3C)ccc2o1,,CC(=O)OC(C)C,,CC(=O)O,,val
US20080306170A1,CC(C)=O.COc1ccccc1CC#N>>COc1ccccc1C(C#N)=C(C)C,,CO,,[K+].[OH-],,val
US04011269,CC1CCC2(O)C(C)(C)C3C=CC2(C)C1C3>>CC1CCC2(O)C(C)(C)C3CCC2(C)C1C3,O=[Pt]=O,,,,,val
US20080096860A1,CCOC(=O)[C@H](C)Oc1cc(NS(=O)(=O)N2CCC2)nc(SCc2cccc(F)c2F)n1>>C[C@@H](CO)Oc1cc(NS(=O)(=O)N2CCC2)nc(SCc2cccc(F)c2F)n1,,C1CCOC1,,[BH4-].[Li+],,val
US20030096812A1,CCOC(=O)N1CC(C)C(=O)C(C)C1.[NH4+]>>CCOC(=O)N1CC(C)C(N)C(C)C1,,CO,,[BH3-]C#N.[Na+],,val
US04786646,C[C@H](N)CCCc1cccnc1.O=C(O)[C@@H](O)c1ccccc1>>CC(CCCc1cccnc1)NC(=O)C(O)c1ccccc1,,CN(C)C=O,CO,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20100016319A1,C1COCCN1.COC(=O)c1sccc1Oc1ccnc(Cl)n1>>COC(=O)c1sccc1Oc1ccnc(N2CCOCC2)n1,,CCO,,,,val
US20020098999A1,CC(C)(C)OC(=O)CNC(=O)[C@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100168122A1,CCCCn1c(=O)n(CCCC(=O)OCC)c(=O)c2[nH]c(Cl)nc21.[H]/N=C(/Cc1cc(Cl)cc(Cl)c1)NO>>CCCCn1c(=O)n(CCCc2nc(Cc3cc(Cl)cc(Cl)c3)no2)c(=O)c2[nH]c(Cl)nc21,,CCO,,C,C[O-].[Na+],val
US20040053931A1,COc1cc2c(cc1OCc1ccccc1)c(-c1cc3cccnc3n1S(=O)(=O)c1ccc(C)cc1)cn2C>>COc1cc2c(cc1O)c(-c1cc3cccnc3n1S(=O)(=O)c1ccc(C)cc1)cn2C,,CC#N,,C[Si](C)(C)Cl,[I-].[Na+],val
US20120190686A1,C1CCOC1.CO.O=C(O)C1CCCC(C(=O)O)C1>>COC(=O)C1CCCC(C(=O)OC)C1,,C1CCOC1,,C[Si](C)(C)Cl,,val
US20080242675A1,CN1CCN(c2cncc(CC(=O)OC(C)(C)C)c2)CC1>>CN1CCN(c2cncc(CC(=O)O)c2)CC1,,C1COCCO1,Cl,,,val
US20140275084A1,BrCCOC(c1ccccc1)(c1ccccc1)c1ccccc1.Brc1cnc[nH]1>>Brc1cn(CCOC(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,,CN(C)C=O,O,[H-].[Na+],,val
US20150025065A1,CS(=O)(=NC#N)c1ccc(Br)cc1>>CS(=N)(=O)c1ccc(Br)cc1,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US04067989,O=C(CBr)c1ccc(Cl)cc1.c1nc[nH]n1>>O=C(Cn1cncn1)c1ccc(Cl)cc1,,CC#N,,CCN(CC)CC,,val
US06214826B1,COc1cccc(NN2C(=O)c3[nH]c4cc(Cl)ccc4c(=O)c3C2=O)c1>>COc1cccc(-n2nc(O)c3c(=O)c4ccc(Cl)cc4[nH]c3c2=O)c1,,CO,,CS(=O)(=O)O,,val
US20100168122A1,NNC(=O)Cc1ccc(F)cc1Cl.O=C(Cl)CCCCl>>O=C(CCCCl)NNC(=O)Cc1ccc(F)cc1Cl,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20120277224A1,COCn1ncc2cc(-c3cc(=O)n4ncc(-c5ccccn5)c4[nH]3)ccc21>>O=c1cc(-c2ccc3[nH]ncc3c2)[nH]c2c(-c3ccccn3)cnn12,,CO,,Cl,,val
US06143763,CN.O=c1ccc2cc(OCCCCl)ccc2[nH]1>>CNCCCOc1ccc2[nH]c(=O)ccc2c1,,CO,,,,val
US20060154945A1,Brc1ccc(Br)s1.CCCC[Sn](CCCC)(CCCC)n1cccn1>>Brc1ccc(-n2cccn2)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20140200216A1,C[C@@H](CN=[N+]=[N-])[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](COS(C)(=O)=O)NC(=O)OC(C)(C)C>>C[C@H]1CNC[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C,[Pd],CO,,CCN(C(C)C)C(C)C,,val
US20070179185A1,CCI.Clc1cccc(C2CCNCC2)c1Cl>>CCN1CCC(c2cccc(Cl)c2Cl)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050004167A1,NNC(=O)c1cc2cccc(Cl)c2o1.O=S(=O)(Cl)c1ccccc1>>O=C(NNS(=O)(=O)c1ccccc1)c1cc2cccc(Cl)c2o1,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20140364433A1,Cc1nc(C(=O)N2CC3CCCC3C2CO)c(-c2ccc(F)cc2)s1.O=C1NC(=O)c2ccccc21>>Cc1nc(C(=O)N2CC3CCCC3C2CN2C(=O)c3ccccc3C2=O)c(-c2ccc(F)cc2)s1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100197679A1,COc1ccc2ncc(=O)n(-c3cnc4c(c3)CCC(NC(=O)OC(C)(C)C)C4)c2n1>>COc1ccc2ncc(=O)n(-c3cnc4c(c3)CCC(N)C4)c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040092556A1,CC(C)(C)OC(=O)N(Cc1ccccn1)Cc1ccc(C(=O)N[C@@H](CCCN[C@@H]2CCCc3cccnc32)C(=O)O)c2ccccc12.Cl>>Cl.O=C(N[C@@H](CCCN[C@@H]1CCCc2cccnc21)C(=O)O)c1ccc(CNCc2ccccn2)c2ccccc12,,CO,,C1COCCO1,,val
US20130296274A1,O=C(O)C1CCN(c2ccccc2)C1=O.O=S(Cl)Cl>>O=C(O)C1(O)CCN(c2ccccc2)C1=O,,CCO,,,,val
US20110034451A1,CCO.Cc1cc2nnc(N)n2nc1Cl>>CCOc1nn2c(N)nnc2cc1C,,CCO,,C,C[O-].[Na+],val
US05358953,N#CC1Cc2ccc([N+](=O)[O-])cc2C1>>N#CC1Cc2ccc(N)cc2C1,[Pd],CO,ClCCl,,,val
US20090197856A1,NO.O=C1CCNc2c(Br)cccc21>>ON=C1CCNc2c(Br)cccc21,,CCO,,Cl,c1ccncc1,val
US20060074119A1,COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(C(N)=O)s3)c2cc1OC.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(C(N)=S)s3)c2cc1OC,,C1COCCO1,,Cl,,val
US04062858,CCOC(=O)C(CCc1ccccc1)C(C)=O.CCn1nccc1N>>CCn1ncc2c(O)c(CCc3ccccc3)c(C)nc21,,O,,,,val
US05536718,O=C1NC2=CCSC2=Cn2cccc21>>c1cc2n(c1)Cc1sccc1NC2,,C1CCOC1,,CO,,val
US20060252834A1,COC(=O)c1ccc(NC(=O)c2ccccc2)cc1>>O=C(O)c1ccc(NC(=O)c2ccccc2)cc1,,CO,,Cl,[K+].[OH-],val
US06153616,C[C@@H](N1CCNCC1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)N2CCN([C@H](C)[C@](O)(Cn3cncn3)c3ccc(F)cc3F)CC2)cc1,,ClC(Cl)Cl,ClCCl,CCN(CC)CC,,val
US20110092497A1,CC1(C)OB(c2ccc(C(N)=O)c(F)c2)OC1(C)C.CN1CCC(COc2ccc(Nc3ncc(Br)n4ccnc34)cc2)CC1>>CN1CCC(COc2ccc(Nc3ncc(-c4ccc(C(N)=O)c(F)c4)n4ccnc34)cc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US06936602B1,CCOCCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3S(C)(=O)=O)cc1>>CCOCCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCN3S(C)(=O)=O)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20030092694A1,C1CNCCN1.Clc1nccnc1Cl>>Clc1nccnc1N1CCNCC1,,CC#N,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20100113502A1,CC1CCN(C(=O)c2ccc3[nH]c4c(c3c2)CN(C(=O)OC(C)(C)C)CC4)CC1.ClCC1CC1>>CC1CCN(C(=O)c2ccc3c(c2)c2c(n3CC3CC3)CCN(C(=O)OC(C)(C)C)C2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20100022598A1,CC(C)(C)Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(CC(O)(c2ccc(Br)cc2)C(F)(F)F)n1.c1c[nH]nn1>>CC(C)(C)Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(CC(O)(c2ccc(-n3nccn3)cc2)C(F)(F)F)n1,[Cu]I,CN1CCCC1=O,O,O=C([O-])[O-].[K+].[K+],,val
US05439909,CCOC(=O)C1=COc2cc(C(C)=O)ccc2O1>>CCOC(=O)C1COc2cc(CC)ccc2O1,[Pd],CC(=O)O,,,,val
US20150141406A1,COc1nccc2c(-c3ccccc3)n[nH]c12.NS(=O)(=O)c1ccc(CBr)cc1>>COc1nccc2c(-c3ccccc3)nn(Cc3ccc(S(N)(=O)=O)cc3)c12,,C1CCOC1,,O,[H-].[Na+],val
US20020120148A1,CC[Si](Cl)(CC)CC.O[C@H](COc1ccccc1)CN(Cc1ccccc1)C1CCCc2ccc(OCc3ccccc3)cc2C1>>CC[Si](CC)(CC)O[C@H](COc1ccccc1)CN(Cc1ccccc1)C1CCCc2ccc(OCc3ccccc3)cc2C1,CN(C)c1ccncc1,CN(C)C=O,,O,c1c[nH]cn1,val
US20030113765A1,C=CC(=C)C(NCCCCCC(=O)n1ccc2c3c(ccc21)NC(C(=O)OC)C3)(c1ccccc1)c1ccc(OC)cc1>>C=CC(=C)C(NCCCCCC(=O)n1ccc2c3c(ccc21)NC(C(=O)O)C3)(c1ccccc1)c1ccc(OC)cc1,,CO,,C1CCOC1,[Li+].[OH-],val
US04966622,CC(=O)CC(=O)C(F)(F)F.NC(=[NH2+])Nc1ccccc1C(F)(F)F>>Cc1cc(C(F)(F)F)nc(Nc2ccccc2C(F)(F)F)n1,,C1CCOC1,,Cl,CC(C)(C)[O-].[K+],val
US20080312226A1,O=C(Nc1ccc2[nH]ccc2c1)OCC(Cl)(Cl)Cl.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>O=C(Nc1ccc2[nH]ccc2c1)N1CCN(c2nc(-c3ccccc3)ns2)CC1,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US20160207893A1,CCOC(=O)c1nc(OC)ncc1SCCNC(=O)OC(C)(C)C>>CCOC(=O)c1nc(OC)ncc1SCCN,,C1COCCO1,,O=C(O)C(F)(F)F,,val
US20120130084A1,O=C(O)CC(=O)O.O=Cc1ccc(F)cc1>>O=C(O)C=Cc1cccc(F)c1,C1CCNCC1,c1ccncc1,,,,val
US20080261979A1,C=CC(F)(F)C(O)c1sc(-c2ccc(C(F)(F)F)nc2)nc1C>>CCC(F)(F)C(O)c1sc(-c2ccc(C(F)(F)F)nc2)nc1C,[Pd],CCOC(C)=O,,,,val
US05753679,BrCc1ccccc1.OC1CCN(Cc2ccccc2)CC1>>c1ccc(COC2CCN(Cc3ccccc3)CC2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US04244961,CC1(C)NC(=O)OC12CCN(C(=O)OCc1ccccc1)CC2>>CC1(C)NC(=O)OC12CCNCC2,[Pd],CCO,,,,val
US04144320,CCCCCCCCCCCCCCCC(=O)Cl.CCCCN>>CCCCCCCCCCCCCCCC(=O)NCCCC,,CCOCC,,,,val
US05462952,NC(=S)c1ccccc1Nc1cccc(C(F)(F)F)c1.NN>>N=C(NN)c1ccccc1Nc1cccc(C(F)(F)F)c1,,CO,,O,,val
US05476841,CCC(=O)C(C)(C)C.CCN(CC)CC.c1ccccc1>>CC[C@@H](N[C@H](C)c1ccccc1)C(C)(C)C,Cl[Ti](Cl)(Cl)Cl,,,Cl,[BH4-].[Na+],val
US20110098276A1,N#Cc1cccc(C(=O)O)c1.NOC1CCN(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)CC1>>N#Cc1cccc(C(=O)NOC2CCN(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)CC2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US20060293354A1,NCC1CCCCC1.O=C(Cl)c1cnc(Cl)nc1C(F)(F)F>>O=C(NCC1CCCCC1)c1cnc(Cl)nc1C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20160221950A1,O=C(NCCc1ncc(Br)cc1Cl)c1ccccc1C(F)(F)F.OB(O)c1ccc(Cl)cc1>>O=C(NCCc1ncc(-c2ccc(Cl)cc2)cc1Cl)c1ccccc1C(F)(F)F,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140315886A1,COc1cc(Br)cc(C(N)=O)c1NC(=O)c1cccnc1>>COc1cc(Br)cc2c(O)nc(-c3cccnc3)nc12,,CCO,,[Na+].[OH-],,val
US20090062265A1,COc1cnc2ccc(F)c(C3(C(=O)O)CO3)c2n1>>O=C(O)C1(O)Cn2c(=O)cnc3ccc(F)c1c32,,C1COCCO1,O,[Li+].[OH-],,val
US05095015,CCC(=O)Cl.O=c1[nH]c2c(c3nc(-c4ccccc4F)cn13)CNCC2>>CCC(=O)N1CCc2[nH]c(=O)n3cc(-c4ccccc4F)nc3c2C1,,CN(C)C=O,,CCN(CC)CC,,val
US20030105084A1,COC(=O)C1CCCNN1.CSc1nccc(C(=O)Cl)n1>>COC(=O)C1CCCN(C(=O)c2ccnc(SC)n2)N1,,ClCCl,,CCN(CC)CC,Cl,val
US05134111,CCc1cccc2c(C=O)ccc(O)c12.O=S(=O)(Cl)Cl>>CCc1cccc2c(C=O)cc(Cl)c(O)c12,,c1ccccc1,,O,,val
US20030187026A1,CC(=O)OC(C)=O.Oc1cncc(Br)c1>>CC(=O)Oc1cncc(Br)c1,,C1CCOC1,CCOCC,CCN(CC)CC,,val
US20050096278A1,OCC1(O)CCCN(Cc2ccccc2)C1>>OCC1(O)CCCNC1,[Pd],C1CCOC1,CO,[H][H],,val
US20140309245A1,Cc1cccc2c(Cl)ncnc12>>Cc1cccc2cncnc12,,ClCCl,,,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccc(C(=O)OC(C)(C)C)cc3)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3ccc(C(=O)OC(C)(C)C)cc3)c2)=C(C)C1=O,,CO,O,O=C([O-])O.[Na+],,val
US06545009B1,COC(=O)c1ccc(C(N)=S)cc1.O=C(CBr)c1ccc(OC(F)F)cc1>>COC(=O)c1ccc(-c2nc(-c3ccc(OC(F)F)cc3)cs2)cc1,,CCO,,,,val
US20100190814A1,CCC(CC)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)Nc1cc(Cl)ccc12)C(=O)NS(C)(=O)=O.CCC(CC)C(=O)Cl>>CCC(CC)C(=O)N1C(=O)C2(c3ccc(Cl)cc31)C(c1cc(Cl)ccc1OC(CC)(CC)C(=O)NS(C)(=O)=O)CC(=O)NC2c1cc(F)ccc1C,CN(C)c1ccncc1,C1CCOC1,,,,val
US20110319378A1,CCOC(=O)C(Br)CC.O=C1CC[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N1>>CCOC(=O)[C@H](CC)N1C(=O)CC[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20150225452A1,N[C@@H]1CCCc2ccccc21.O=C1OC(=O)[C@H]2CCCC[C@H]12>>O=C(N[C@@H]1CCCc2ccccc21)[C@@H]1CCCC[C@H]1C(=O)O,,ClCCl,,,,val
US20120214769A1,BrCc1ccccc1.CC(C)(C)c1ccc(CC(=O)O)cc1>>CC(C)(C)c1ccc(CC(=O)OCc2ccccc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110098429A1,Brc1cccc(Br)c1.COc1ccccc1B(O)O>>COc1ccccc1-c1cccc(Br)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])O.[Na+],,val
US20100010035A1,CCc1nc(C)cc2c1c(CC)nn2Cc1ccc(-c2cc(C)sc2S(=O)(=O)N(COCCOC)c2noc(C)c2C)c(COC)c1>>CCc1nc(C)cc2c1c(CC)nn2Cc1ccc(-c2cc(C)sc2S(=O)(=O)Nc2noc(C)c2C)c(COC)c1,,CCO,,Cl,,val
US20100029666A1,C=CCCC[C@@H]1C[C@H]1OC(=O)N[C@H](C(=O)OC)C(C)(C)C>>C=CCCC[C@@H]1C[C@H]1OC(=O)N[C@H](C(=O)O)C(C)(C)C,,CO,O,[Li]O,,val
US20160257657A1,Brc1ccccc1.C[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H](C)N1>>C[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H](C)N1c1ccccc1,,C1COCCO1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20150018547A1,CCN=C=NCCCN(C)C.COCOc1c(C(=O)O)sc2cc(OCc3ccc(Cl)cc3Cl)ccc12>>COCOc1c(C(N)=O)sc2cc(OCc3ccc(Cl)cc3Cl)ccc12,,O,,CN(C)C=O,,val
US20130178497A1,COc1nc(-c2nnc3n2CCC[C@]3(Oc2cc(F)c(F)c(F)c2)C(C)(C)O)ccc1-n1cnc(C)c1.O=C(O)C(O)c1ccccc1>>COc1nc(-c2nnc3n2CCC[C@]3(Oc2cc(F)c(F)c(F)c2)C(C)(C)OC(=O)[C@@H](O)c2ccccc2)ccc1-n1cnc(C)c1,,CCO,,CCCCCC,,val
US20140073799A1,CC(C)(C)[Si](C)(C)Cl.O=[N+]([O-])c1cccc(S(=O)(=O)CCO)c1>>CC(C)(C)[Si](C)(C)OCCS(=O)(=O)c1cccc([N+](=O)[O-])c1,CN(C)c1ccncc1,ClCCl,,,,val
US20120028961A1,CC1(C)Oc2ccc(CNC(=O)C(F)(F)F)cc2C1=O>>CC1(C)Oc2ccc(CN)cc2C1=O,,CO,N,,,val
US20100234432A1,CC1CC1CO.COC(=O)c1c(C(F)(F)F)cc(-c2ccc(C)c(F)c2)nc1Cl>>Cc1ccc(-c2cc(C(F)(F)F)c(C(=O)O)c(OCC3CC3C)n2)cc1F,,C1CCOC1,,Cl,[H-].[Na+],val
US06313094B1,CC(C)(C)OC(=O)N1CSC[C@H]1C(=O)O.CC(C)(N)CO>>CC(C)(CO)NC(=O)[C@@H]1CSCN1C(=O)OC(C)(C)C,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20050245575A1,CC[C@H](C)O.N#Cc1ccc(F)c(C(F)(F)F)c1>>CC[C@H](C)Oc1ccc(C#N)cc1C(F)(F)F,,C1CCOC1,,[H-].[Na+],,val
US04714774,CCC(=O)OC(=O)CC.CCCc1c(OCCCOc2ccc(C(=O)O)cc2Br)ccc(C(C)=O)c1O>>CCCc1c(OCCCOc2ccc(C(=O)O)cc2Br)ccc(C(C)=O)c1OC(=O)CC,,c1ccncc1,,,,val
US04980356,C=CCBr.Nc1nc2ccc(OC(F)(F)F)cc2s1>>Br.C=CCn1c(=N)sc2cc(OC(F)(F)F)ccc21,,CCO,,,,val
US07030145B2,COc1ccccc1CCl.Cc1ccc(S(=O)(=O)c2ccc(O)cc2)c(Br)n1>>COc1ccccc1COc1ccc(S(=O)(=O)c2ccc(C)nc2Br)cc1,,CC#N,CCOC(C)=O,CO,O=C([O-])[O-].[K+].[K+],val
US06184225B2,CCOC(=O)C(Cl)Cl.O=[N+]([O-])c1cc(F)cc(F)c1>>CCOC(=O)C(Cl)c1c(F)cc([N+](=O)[O-])cc1F,,CN(C)C=O,,Cl,CC(C)(C)[O-].[K+],val
US05049551,CCCC(CCC)C(=O)Cl.NCC(=O)O>>CCCC(CCC)C(=O)NCC(=O)O,,O,,[Na+].[OH-],,val
US20050171115A1,CC1(C)CO1.OC1(C(CN2CCNCC2)c2cccc(OC(F)(F)F)c2)CCCCC1>>CC(C)(O)CN1CCN(CC(c2cccc(OC(F)(F)F)c2)C2(O)CCCCC2)CC1,,CCO,,Cl,Cl,val
US20140045862A1,COc1ccc(CNc2ccncn2)c(OC)c1.O=S(=O)(Cl)c1c(F)cc(F)cc1F>>COc1ccc(CN(c2ccncn2)S(=O)(=O)c2c(F)cc(F)cc2F)c(OC)c1,,CC#N,,C1CN2CCN1CC2,,val
US20040009995A1,Cc1cccc(C(=O)Cl)c1I>>Cc1cccc(CO)c1I,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080114002A1,CC(=O)Cl.N=C(NO)c1ccc(Oc2cc(Cl)ccc2N)c(Cl)c1.c1ccncc1>>CC(=O)Nc1ccc(Cl)cc1Oc1ccc(-c2noc(C)n2)cc1Cl,,Cl,,,,val
US20080293782A1,C=CCCOc1cccc(OCc2ccccc2)c1C(=O)O.O=C(Cl)C(=O)Cl>>C=CCCOc1cccc(OCc2ccccc2)c1C(=O)Cl,CN(C)C=O,ClCCl,,,,val
US05834463,CC1CC(=O)N(Cc2ccccc2)c2ccccc2N1.O=C(Cl)CN1C(=O)c2ccccc2C1=O>>CC1CC(=O)N(Cc2ccccc2)c2ccccc2N1C(=O)CN1C(=O)c2ccccc2C1=O,,CCOCC,,,,val
US20110065708A1,Clc1ccc(Cl)nn1.NNC(=O)C1(c2ccc3ncccc3c2)CC1>>Clc1ccc2nnc(C3(c4ccc5ncccc5c4)CC3)n2n1,,CCCCO,,,,val
US20060264486A1,BrCCBr.Oc1ccc2cc(Br)ccc2c1Br>>BrCCOc1ccc2cc(Br)ccc2c1Br,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150274705A1,CC(C)(C)OC(=O)N1CC2CC(Nc3nc(Cl)ncc3Cl)CC2C1.Cc1c2ccc(N)cc2nn1C>>Cc1c2ccc(Nc3ncc(Cl)c(NC4CC5CN(C(=O)OC(C)(C)C)CC5C4)n3)cc2nn1C,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20120022056A1,NC(=O)COc1c(Br)ccc(F)c1CCN1CCN(c2cccc3nc(C(F)(F)F)ccc23)CC1>>O=C1COc2c(ccc(F)c2CCN2CCN(c3cccc4nc(C(F)(F)F)ccc34)CC2)N1,[Cu]I,CN1CCCC1=O,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US04965368,CC(C)OCC1CNC(C)(C)O1.O=C(Cl)C(Cl)Cl>>CC(C)OCC1CN(C(=O)C(Cl)Cl)C(C)(C)O1,,c1ccccc1,,CCN(CC)CC,,val
US20130005771A1,CCCc1noc(C=Cc2ccc(OC)c(N)c2)n1.CS(=O)(=O)Cl>>CCCc1noc(C=Cc2ccc(OC)c(NS(C)(=O)=O)c2)n1,,ClCCl,,c1ccncc1,,val
US04221715,Clc1ccc2c(c1)N=C(c1ccncc1)c1cc(Cl)ccc1O2>>Clc1ccc2c(c1)NC(c1ccncc1)c1cc(Cl)ccc1O2,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130123230A1,COCCN.O=C(N=C=S)c1ccccc1>>COCCNC(=S)NC(=O)c1ccccc1,,ClCCl,,,,val
US03940458,CC(Cl)(Cl)C(=O)Cl.CN(C)C=O>>CN(C)C(=O)C(=O)C(C)(Cl)Cl,,CCN(CC)CC,,,,val
US05804559,CC(C)(C)OC(=O)ON=C(C#N)c1ccccc1.CNCCNC>>CNCCN(C)C(=O)OC(C)(C)C,,CCOCC,,C[O-].[Na+],,val
US04837236,CC1CNCC(C)O1.COCOc1cccc(-c2c(S(=O)(=O)[O-])ccc(C)c2CC(C)C)c1>>COCOc1cccc(CC(C)CN2CC(C)OC(C)C2)c1,,[Na+],[OH-],,,val
US20140275015A1,O=C(O)c1cccc(C(F)(F)F)c1Cl.c1cnc(-n2nnc3c2CCNC3)nc1>>O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(nnn2-c2ncccn2)C1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140142137A1,CN.COc1c(C(=O)NCc2ccc(F)cc2)cccc1C(=O)N1CCSC1=S>>CNC(=O)c1cccc(C(=O)NCc2ccc(F)cc2)c1OC,,ClCCl,,,,val
US04673746,COc1cccc(Cl)c1Cl.O=C(Cl)c1ccc(Cl)c(Cl)c1>>COc1ccc(C(=O)c2ccc(Cl)c(Cl)c2)c(Cl)c1Cl,,ClCCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20100173955A1,CC(C)(C)OC(=O)Cc1ccc(Oc2ccc(C(=O)Nc3ccc(Cl)c(Cl)c3)cc2)c(CNS(C)(=O)=O)c1>>CS(=O)(=O)NCc1cc(CC(=O)O)ccc1Oc1ccc(C(=O)Nc2ccc(Cl)c(Cl)c2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04900752,CC(C)C(=O)Cl.CC1(C)Oc2cc3nonc3cc2C(N)C1O>>CC(C)C(=O)NC1c2cc3nonc3cc2OC(C)(C)C1O,,ClCCl,,CCN(CC)CC,,val
US20090186898A1,C1COCCN1.O=C(O)c1ccc(Cl)nc1>>O=C(c1ccc(Cl)nc1)N1CCOCC1,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20040110826A1,CCOC(=O)c1cnc(SC)nc1Cl.NN>>CCOC(=O)c1cnc(SC)nc1NN,,CCO,,O,,val
US20160016948A1,CC[C@@H](C)Nc1cc(Br)ncc1[N+](=O)[O-]>>CC[C@@H](C)Nc1cc(Br)ncc1N,[Fe],O,,CC(=O)O,,val
US20030212055A1,CC(C)(C)OC(=O)N1CCC(CO)CC1.COc1cc2c(Cl)cnnc2cc1O>>COc1cc2c(Cl)cnnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04638005,Cc1cnc(C)cn1.O=S1(=O)CCCO1>>CC1=CN(CCC=S(=O)=O)C(C)C=N1,,CCOC(C)=O,,,,val
US20140057893A1,C1CNC1.N#Cc1cc(OCc2ccccc2)ccc1CC(=O)O>>N#Cc1cc(OCc2ccccc2)ccc1CC(=O)N1CCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090054425A1,Cc1ccc(S(=O)(=O)n2ccc3c(Cl)nc(Cl)nc32)cc1.Cn1ncc2ccc(N)cc21>>Cc1ccc(S(=O)(=O)n2ccc3c(Nc4ccc5cnn(C)c5c4)nc(Cl)nc32)cc1,,C1COCCO1,O,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US05716963,COc1ccc(OC)c(N)c1.O=C(Cl)Cc1ccccc1>>COc1ccc(OC)c(NC(=O)Cc2ccccc2)c1,,c1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20020099212A1,CCOC(=O)c1ccc2[nH]c(=O)c(=O)n(Cc3ccc(Cl)cc3Cl)c2c1.CI>>CCOC(=O)c1ccc2c(c1)n(Cc1ccc(Cl)cc1Cl)c(=O)c(=O)n2C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120101093A1,Nc1ccc([N+](=O)[O-])c(N)c1>>Nc1ccc(N)c(N)c1,[Pd],CCOC(C)=O,CO,,,val
US20150322024A1,CC(C)(C)OC(=O)NCc1cccc(N2CCSCC2)c1.Cl.ClCCl>>Cl.Cl.NCc1cccc(N2CCSCC2)c1,,CCOCC,,C1COCCO1,,val
US20060241083A1,CC(C)(C)OP([O-])OC(C)(C)C.Cc1nc(-c2ccccc2)c(C=O)c2c1OC(C)(C)OC2>>Cc1nc(-c2ccccc2)c(C(O)P(=O)(OC(C)(C)C)OC(C)(C)C)c2c1OC(C)(C)OC2,,C1CCOC1,CCOCC,[H-].[Na+],,val
US20090181959A1,N#CCC(n1cc(-c2ncnc3[nH]ccc23)cn1)C1(CN)CCCC1.O=C(Cl)c1ccccc1>>N#CCC(n1cc(-c2ncnc3[nH]ccc23)cn1)C1(CNC(=O)c2ccccc2)CCCC1,,ClCCl,,,,val
US20060025474A1,CCC(CC)(c1ccc(O)c(C)c1)c1ccc(CCC(O)C(C)(C)C)c(C)c1.O=C1c2ccccc2C(=O)N1CCCBr>>CCC(CC)(c1ccc(CCC(O)C(C)(C)C)c(C)c1)c1ccc(OCCCN2C(=O)c3ccccc3C2=O)c(C)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130190289A1,CC(C)(C)OC(=O)N[C@H]1CCCCNC1=O.CN(C)CCBr>>CN(C)CCN1CCCC[C@H](N)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20050148623A1,CC(C)(C)OC(=O)[C@@H](N1CCN(Cc2ccc(C(F)(F)F)cc2)C1=O)C(C)(C)C>>CC(C)(C)[C@@H](C(=O)O)N1CCN(Cc2ccc(C(F)(F)F)cc2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040121965A1,CCOC(=O)/C(C)=C/[C@@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)OC(C)(C)C)C(C)(C)c1ccccc1)C(C)(C)c1ccc(OC)cc1>>COc1ccc(C(C)(C)[C@H](NC(=O)[C@@H](N(C)C(=O)OC(C)(C)C)C(C)(C)c2ccccc2)C(=O)N(C)[C@H](/C=C(\C)C(=O)O)C(C)C)cc1,,CO,,O,[Li+].[OH-],val
US20160031876A1,COC(=O)C1(c2ccccc2)CC=CC1>>O=C(O)C1(c2ccccc2)CC=CC1,,CO,,[Na+].[OH-],,val
US04775669,CC(=O)OCC[C@H]1NC(=O)[C@H]1C(C)N.O=C(Cl)OCc1ccccc1[N+](=O)[O-]>>CC(=O)OCC[C@@H]1NC(=O)[C@H]1C(C)NC(=O)OCc1ccccc1[N+](=O)[O-],,ClCCl,,c1ccncc1,,val
US20130261159A1,COCc1nc(CO)co1.CS(=O)(=O)Cl>>COCc1nc(COS(C)(=O)=O)co1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,N#N,val
US20100092387A1,COc1ccc2nc(-c3ccc(O)cc3)cn2c1.Cc1ccc(S(=O)(=O)OCCCO)cc1>>COc1ccc2nc(-c3ccc(OCCCOS(=O)(=O)c4ccc(C)cc4)cc3)cn2c1,,C1CCOC1,CN(C)C=O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06034239,C=C(C)Cc1c(O)c(Br)cc2c1C(CCNC(=O)CC)CC2>>CCC(=O)NCCC1CCc2cc(Br)c3c(c21)CC(C)(C)O3,,ClCCl,,,,val
US20110213062A1,CCP(=O)(O)C(CCO)c1ccccc1.OCCCCO>>CCP(=O)(OCCCCO)C(CCO)c1ccccc1,,Cc1ccccc1,,,,val
US20060160864A1,C1COCCN1.O=Cc1cc(Br)ccc1F>>O=Cc1cc(Br)ccc1N1CCOCC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160271030A1,COc1ccc(N=Nc2n(C)cc[n+]2C)cc1.NCCN(CCN)CCN.[I-]>>Cn1cc[n+](C)c1N=Nc1ccc(NCCN(CCN)CCN)cc1.[I-],,CC(C)O,,,,val
US05574142,CC(=O)OC[C@H]1OC(Br)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O.N=C(N)S.O=C(O)CCI>>CC(=O)OC[C@H]1O[C@@H](SCCC(=O)O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O,,CC(C)=O,,,,val
US20050075342A1,CCOC(=O)CCCCc1c(CN2C(=O)c3ccccc3C2=O)nn2c(CC)ccc2c1-c1cncc(C)c1>>CCOC(=O)CCCCc1c(CN)nn2c(CC)ccc2c1-c1cncc(C)c1,,CCO,,NN,O,val
US20140039011A1,C=CCOC[C@@H](N)C(C)C.C=CCn1cnc(C[C@@H](NC(=O)OCc2ccccc2)C(=O)O)c1>>C=CCOC[C@@H](NC(=O)[C@@H](Cc1cn(CC=C)cn1)NC(=O)OCc1ccccc1)C(C)C,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20110112062A1,COC(=O)Cl.N[C@@H]1CCN(C(=O)NC2C3CC4CC(C3)CC2C4)C1>>COC(=O)N[C@@H]1CCN(C(=O)NC2C3CC4CC(C3)CC2C4)C1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20100234354A1,Cn1cc(-c2ccc(=O)n(Cc3cccc(-c4ncc(O)cn4)c3)n2)cn1.OCCOC1CCCCO1>>Cn1cc(-c2ccc(=O)n(Cc3cccc(-c4ncc(OCCO)cn4)c3)n2)cn1,,C1CCOC1,ClCCl,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20010016579A1,CN1CCNCC1.Cc1c(Cl)cc2nc(S)oc2c1C>>Cc1c(Cl)cc2nc(N3CCN(C)CC3)oc2c1C,,ClC(Cl)Cl,,,,val
US20100267723A1,C[C@H]1COC[C@H](C)N1.O=Cc1cc(F)c(Cl)cc1F>>C[C@H]1COC[C@H](C)N1Cc1cc(F)c(Cl)cc1F,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US06162824,COC(=O)[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)[C@@H](C)O.OC1(c2ccccc2)c2ccccc2-c2ccsc21>>C[C@@H](OC1(c2ccccc2)c2ccccc2-c2ccsc21)[C@H](N)C(=O)O,O=C(O)C(F)(F)F,,,O=S(=O)(O)O,,val
US05217845,Cc1ccc(C(=O)O)cc1.Cc1ccc(Nc2ccc(C)cc2)cc1>>Cc1ccc(-c2c3cc(C)ccc3nc3ccc(C)cc23)cc1,,O,,N,,val
US20140296226A1,NC1=N[C@@]2(CCO1)c1cc(N)ccc1Oc1c(F)cc(C3=CCOCC3)cc12>>NC1=N[C@@]2(CCO1)c1cc(N)ccc1Oc1c(F)cc(C3CCOCC3)cc12,[Pd],CCO,,[H][H],,val
US05596002,Clc1ccc2c(Cl)ccnc2c1.NC1CCCCC1N1CCCC1>>Clc1ccc2c(NC3CCCCC3N3CCCC3)ccnc2c1,,CC#N,CCO,,,val
US06362166B1,CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O.CSCC[C@H](N)CO>>CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O.CSCC[C@H](N)C=O,,CS(C)=O,,,,val
US20040014802A1,CCCC(=O)Cl.Nc1n[nH]c2cccc(Cl)c12>>CCCC(=O)Nc1n[nH]c2cccc(Cl)c12,,c1ccncc1,,,,val
US06498165B1,CO.C[C@H](Nc1nc(Cl)cc(-n2cnc3ccccc32)n1)c1ccccc1>>COc1cc(-n2cnc3ccccc32)nc(N[C@@H](C)c2ccccc2)n1,,CO,,C[O-].[Na+],,val
US20020193367A1,CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(C#N)c2)cc1C#Cc1ccccc1>>CN(C)c1cc2c(cc1C#Cc1ccccc1)NC(=O)CC(c1cccc(C#N)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US04116956,NNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NC1.O=C(Cl)Cc1ccccc1>>O=C(Cc1ccccc1)NNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NC1,,ClC(Cl)Cl,,CCN(CC)CC,CCOCC,val
US20100286117A1,CCCc1noc(C)c1CO.COC(=O)c1ccc(Cl)nc1>>CCCc1noc(C)c1COc1ccc(C(=O)OC)cn1,,C1CCOC1,C1CCOC1,O,[H-].[Na+],val
US20040209865A1,Brc1ccc2nc(CN3CCCC3)ccc2c1>>Brc1ccc2c(c1)CCC(CN1CCCC1)N2,,CC(=O)O,,[Na+].[OH-],,val
US20030195362A1,Cl.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.OCc1cncs1>>Cl.O=C(OCc1cncs1)Oc1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,,CCN(CC)CC,,val
US20110275797A1,CCNc1ccccc1-c1ccc(C(=O)OC)c([N+](=O)[O-])c1.CI>>CCN(C)c1ccccc1-c1ccc(C(=O)OC)c([N+](=O)[O-])c1,,CCOCC,O,CN(C)C=O,[H-].[Na+],val
US20140275040A1,COC(=O)c1ccc(C(=O)O)nc1.NC1CC1>>COC(=O)c1ccc(C(=O)NC2CC2)nc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130165464A1,COc1ccc(CN)c(OC)c1.Cc1cnc(F)cc1-n1cc(-c2ccccc2Cl)c(-c2nccn2COCC[Si](C)(C)C)c1>>COc1ccc(CNc2cc(-n3cc(-c4ccccc4Cl)c(-c4nccn4COCC[Si](C)(C)C)c3)c(C)cn2)c(OC)c1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20160009704A1,COc1ccc(CNC(=O)c2cn(CCCCc3nnc(NC(=O)Cc4cccc(OC(F)(F)F)c4)s3)nn2)c(OC)c1>>NC(=O)c1cn(CCCCc2nnc(NC(=O)Cc3cccc(OC(F)(F)F)c3)s2)nn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06090846,CC(C)(C)OC(=O)N=COCNCCC[C@H](N)C(=O)OC(C)(C)C.Cl.Cl>>Cl.Cl.N=COCNCCC[C@H](N)C(=O)O,,C1COCCO1,,N#N,,val
US20100010035A1,CCc1cc2c(c(-c3ccccc3)cc(=O)n2C(S)c2ccc(-c3ccsc3S(=O)(=O)N(COCCOC)c3noc(C)c3C)cc2)c(CC)n1>>CCc1cc2c(c(-c3ccccc3)cc(=O)n2C(S)c2ccc(-c3ccsc3S(=O)(=O)Nc3noc(C)c3C)cc2)c(CC)n1,,CCO,O,Cl,O=C([O-])O.[Na+],val
US05037825,CC=O.CN1CCC(C)(C)c2ccc(Br)cc21>>CC(O)c1ccc2c(c1)N(C)CCC2(C)C,,C1CCOC1,,[Mg],,val
US20060183762A1,CCO.COc1c(F)c(F)cc(C(=O)O)c1F>>CCOC(=O)c1cc(F)c(F)c(OC)c1F,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,O=C([O-])O.[Na+],val
US20060276536A1,CC(C)=O.COCOc1ccc(C=O)cc1OC>>COCOc1ccc(C=CC(C)=O)cc1OC,,CCO,,O,[Na+].[OH-],val
US20100009969A1,CC(=O)Cl.ClCCCOc1ccc(-c2nc3c(s2)CNCC3)cc1>>CC(=O)N1CCc2nc(-c3ccc(OCCCCl)cc3)sc2C1,,ClCCl,,CCN(CC)CC,O,val
US04786646,Brc1ccccn1.C#CCCCO>>OCCCC#Cc1ccccn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,ClCCl,,CCN(CC)CC,,val
US20160206616A1,CCOC(=O)C1=C(CBr)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br.O=C(O)[C@@H]1CS(=O)(=O)CCN1>>CCOC(=O)C1=C(CN2CCS(=O)(=O)C[C@H]2C(=O)O)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20160016874A1,CCOC(CC)CCCCO.CS(=O)(=O)Cl>>CCOC(CC)CCCCCl,,CN(C)C=O,,c1ccncc1,,val
US20040132727A1,COc1cc2ncnc(Oc3ccc(N)cc3Cl)c2cc1OC.O=C(N=C=S)c1ccccc1Cl>>COc1cc2ncnc(Oc3ccc(NC(=S)NC(=O)c4ccccc4Cl)cc3Cl)c2cc1OC,,Cc1ccccc1,,CCO,,val
US20070116850A1,O=C(/C=C/c1ccc(O)c(O)c1)O[C@@H]1C[C@](O)(C(=O)O)C[C@@H](O)[C@H]1O>>O=C(O)c1cc(O)c(O)c(O)c1,,O,,[K],,val
US20110297881A1,CCOc1ccc(-c2ccc(C=COC)c(F)c2F)c(F)c1F>>CCOc1ccc(-c2ccc(CC=O)c(F)c2F)c(F)c1F,,CC(C)=O,,Cl,O,val
US20150166480A1,CC(C)(O)CN1CCC(COc2ccc(Cl)nc2)CC1.CCN(CC)S(F)(F)F>>CC(C)(F)CN1CCC(COc2ccc(Cl)nc2)CC1,,ClCCl,,O=C([O-])O.[Na+],,val
US20040010026A1,CCCOC(=O)CN[C@@](C)(C(=O)N1CCCC1)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C.Cc1ccc(S(=O)(=O)O)cc1>>CCCOC(=O)CN[C@@](C)(C(=O)N1CCCC1)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C.Cc1ccc(S(=O)(=O)O)cc1,,CCCO,O,Cl,[Na+].[OH-],val
US20130274255A1,C[Si](C)(C)CCOCn1nc(-c2ccc(Br)cc2)c2c1-c1ccsc1C2.OB(O)c1ccc(C(F)(F)F)cc1>>C[Si](C)(C)CCOCn1nc(-c2ccc(-c3ccc(C(F)(F)F)cc3)cc2)c2c1-c1ccsc1C2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20090227591A1,CC(C)OB(OC(C)C)OC(C)C.COc1ccc(C(F)(F)F)cc1C1=C(Br)CCC1>>COc1ccc(C(F)(F)F)cc1C1=C(B(O)O)CCC1,,C1CCOC1,,[Li]CCCC,,val
US20120115846A1,C=Cc1ccc2c(c1)c(=O)n(Cc1ccc(OC)c(OC)c1)c(=O)n2C1CCOCC1.O=[O+][O-]>>COc1ccc(Cn2c(=O)c3cc(C=O)ccc3n(C3CCOCC3)c2=O)cc1OC,,ClCCl,,,,val
US20160107997A1,COC(=O)N1CCc2c(cccc2N(CC(=O)N(CCN(C)C)Cc2ccccc2)C(=O)C(F)(F)F)C1C>>COC(=O)N1CCc2c(cccc2NCC(=O)N(CCN(C)C)Cc2ccccc2)C1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20090312335A1,CN1C[C@H](c2ccccc2)n2nc(-c3nnc(Cc4ccc(F)cc4)o3)c(OCc3ccccc3)c2C1=O>>CN1C[C@H](c2ccccc2)n2nc(-c3nnc(Cc4ccc(F)cc4)o3)c(O)c2C1=O,[Pd],CO,,,,val
US20020025991A1,C/C=C/n1c2ccccc2c2ccccc21>>CC=Cn1c2ccccc2c2ccccc21,,ClCCl,,CO,,val
US20070299074A1,CC(=O)Cl.COc1cccc(OC)c1CNC(=N)Nc1nc2c(s1)CNCC2>>COc1cccc(OC)c1CNC(=N)Nc1nc2c(s1)CN(C(C)=O)CC2,,C1CCOC1,,CCN(CC)CC,,val
US20140046059A1,O=S(=O)(O)Cl.OCCNCc1ccccc1>>O=S(=O)(O)OCCNCc1ccccc1,,ClC(Cl)(Cl)Cl,,,,val
US20100093088A1,CC(=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C.CC(C)(C)O[K]>>C=C(C)c1cc2c(cc1C)C(C)(C)CCC2(C)C,,C1CCOC1,,,,val
US20070203133A1,COCc1nc2nc(-c3ncccc3C(F)(F)F)ccc2c2[nH]c3ccc(Br)cc3c(=O)c12>>COCc1nc2nc(-c3ncccc3C(F)(F)F)ccc2c2c1C(O)c1cc(Br)ccc1N2,,CC(C)O,,[BH4-].[Na+],,val
US20020107278A1,BrCCOc1ccccc1.CC(C)(C)OC(=O)N1CCC2Nc3cccc(-c4ccc(Cl)cc4Cl)c3C2CC1>>CC(C)(C)OC(=O)N1CCC2c3c(-c4ccc(Cl)cc4Cl)cccc3N(CCOc3ccccc3)C2CC1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20020119960A1,CC(C)(C)OC(=O)N1CCC(c2ccccc2)[C@H]1C(=O)NN1CCN(C(c2ccccc2)c2ccccc2)CC1>>O=C(NN1CCN(C(c2ccccc2)c2ccccc2)CC1)[C@H]1NCCC1c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20120202785A1,C[C@H](N)c1nc2ccc(F)c(C(=O)N3CCOCC3)c2n1C1CC1.N#Cc1c(N)ncnc1Cl>>C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)c(C(=O)N3CCOCC3)c2n1C1CC1,,CC(C)O,CO,CCN(C(C)C)C(C)C,,val
US20040171797A1,CC(=O)OC(C)=O.N[C@H](CCCCNC(=O)OCc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)OCc1ccccc1>>CC(=O)N[C@H](CCCCNC(=O)OCc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)OCc1ccccc1,,O,,Cl,[Na+].[OH-],val
US20070191457A1,COC(=O)c1c(Cl)cc(Cl)cc1CBr.COc1ccc(N)cc1OCCN1CCCCCC1.Cl>>COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCCCC1.Cl,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20100022535A1,Cc1cccc(-c2[nH]c(Cc3ccc(F)c(C#N)c3)nc2-c2ccc3ncccc3c2)n1.[N-]=[N+]=[N-]>>Cc1cccc(-c2[nH]c(Cc3ccc(F)c(-c4nnn[nH]4)c3)nc2-c2ccc3ncccc3c2)n1,,Cc1ccccc1,,[Na+].[OH-],,val
US20120220589A1,COC(=O)c1ccc2[nH]c(=O)c(N3CCCc4ccccc43)nc2c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1ccc2nc(OS(=O)(=O)C(F)(F)F)c(N3CCCc4ccccc43)nc2c1,,ClCCl,,c1ccncc1,,val
US20020006944A1,COc1c(C)cc(C)cc1/C=C/C(=O)O>>COc1c(C)cc(C)cc1CCC(=O)O,[Pd],CC(=O)O,,[H][H],,val
US20140155391A1,CO/N=C\c1ccc(C(=O)OC)cc1OCC1CC1>>COC(=O)c1ccc(CN)c(OCC2CC2)c1,[Pd],CO,,Cl,,val
US20110293654A1,CC(C)(C)OC(=O)NC[C@H]1COCc2nc3c(N)nc4ccccc4c3n21>>NC[C@H]1COCc2nc3c(N)nc4ccccc4c3n21,,CCO,,Cl,,val
US20050239780A1,CC(C)(C)OC(=O)C(C#N)c1ccc(C#N)cc1[N+](=O)[O-]>>CC(C)(C)OC(=O)c1c(N)[nH]c2cc(C#N)ccc12,,CC(=O)O,,,,val
US04107310,CCOC(=O)c1c(O)nc2c(C(F)(F)F)cccc2c1O.Nc1nccs1>>O=C(Nc1nccs1)c1c(O)nc2c(C(F)(F)F)cccc2c1O,,Cc1ccccc1C,,,,val
US20040235892A1,Nc1ccc(-c2ccc(CN3CCOCC3)c3[nH]nc(N)c23)cc1.O=C=Nc1cccc(F)c1>>Nc1n[nH]c2c(CN3CCOCC3)ccc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12,,ClCCl,,,,val
US20090181956A1,CNN.O=c1oc(-c2cc(Br)cn2-c2ncccc2Cl)nc2c(Br)cc(Br)cc12>>CN(N)C(=O)c1cc(Br)cc(Br)c1NC(=O)c1cc(Br)cn1-c1ncccc1Cl,,O,,C1CCOC1,,val
US20090036436A1,O=Cc1ccnc(Cl)c1.[C-]#[N+]CC(=O)N1CC=CC1>>O=C([C@@H]1N=CO[C@H]1c1ccnc(Cl)c1)N1CC=CC1,,CO,,[K+].[OH-],,val
US05736534,CC(C)c1ccc2c(c1)NCC2.COc1cc2ncnc(Cl)c2cc1OC>>COc1cc2ncnc(N3CCc4ccc(C(C)C)cc43)c2cc1OC,,CC(C)O,,,,val
US05478939,CN1C[C@@H]2C[C@H]1CN2.Cc1nsc(Cl)n1>>Cc1nsc(N2C[C@@H]3C[C@H]2CN3C)n1,,C1CCOC1,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20050101647A1,CCN=C=O.Nc1cccc(-c2nc3ccc(Br)cc3o2)c1>>CCNC(=O)Nc1cccc(-c2nc3ccc(Br)cc3o2)c1,,c1ccncc1,,O,,val
US20160039834A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNC[C@@H](O)COc1ccc(F)c(Br)c1>>CN(C[C@@H](O)COc1ccc(F)c(Br)c1)C(=O)OC(C)(C)C,,ClCCl,,,,val
US04775692,C=[N+]=[N-].O=C(O)c1cccc(Cl)c1>>COC(=O)c1cccc(Cl)c1,,CCOCC,,,,val
US20080058356A1,Nc1cc(-c2ccco2)nc(-c2nccs2)n1.O=C(Cl)Cc1ccc(F)cc1>>O=C(Cc1ccc(F)cc1)Nc1cc(-c2ccco2)nc(-c2nccs2)n1,,c1ccncc1,,,,val
US04649146,Cc1cccnc1N.Cc1nc(N)sc1C(=O)CBr>>Cc1nc(N)sc1-c1cn2cccc(C)c2n1,,CC(=O)N(C)C,,Br,,val
US20110281870A1,CC(C)C[C@H](N)C(N)=O.O=S(=O)([O-])c1ccc(Br)cc1[C@@H]1CC[C@@H]2CN(c3cccc(C(F)(F)F)n3)C[C@@H]21>>CC(C)C[C@H](N[C@H]1CC[C@@H]2CN(c3cccc(C(F)(F)F)n3)C[C@H]12)C(N)=O,,CC#N,,,,val
US20060074071A1,CC(C)(C)OC(=O)N1CCC[C@H]1CNc1cccc(-c2ccccc2)c1.COc1ccc(C(=O)Cl)cc1OC>>COc1ccc(C(=O)N(C[C@@H]2CCCN2C(=O)OC(C)(C)C)c2cccc(-c3ccccc3)c2)cc1OC,,CC#N,ClCCl,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20040014962A1,CS(=O)(=O)Cl.O=C(OCc1ccc([N+](=O)[O-])cc1)N1CC(O)C1>>CS(=O)(=O)OC1CN(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1,,ClCCl,,CCN(CC)CC,,val
US20100113438A1,CC(=O)c1ccc(N2CCNCC2)cc1.O=C(Cl)c1ccccc1>>CC(=O)c1ccc(N2CCN(C(=O)c3ccccc3)CC2)cc1,,ClCCl,,,,val
US05447656,CC1(C)OC[C@H](CO)O1.CCCOc1cccc(-c2ncc(-c3ccc(O)cc3)cn2)c1>>CCCOc1cccc(-c2ncc(-c3ccc(OC[C@H]4COC(C)(C)O4)cc3)cn2)c1,,ClC(Cl)Cl,,,,val
US08647827B2,CI.CN(C)c1ccc(-c2ccncc2)cc1F>>CN(C)c1ccc(-c2cc[n+](C)cc2)cc1F.[I-],,CC#N,,,,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccccn2)c1C#N.NCc1nc(C(F)(F)F)ccc1Cl>>N#Cc1c(NCc2ncc(C(F)(F)F)cc2Cl)nc(N)nc1-c1ccccn1,,COCCOC,,C1CCC2=NCCCN2CC1,Cl,val
US20040242584A1,CNC(C)=O.Fc1ccc(CBr)cc1>>CC(=O)N(C)Cc1ccc(F)cc1,,C1CCOC1,,[H-].[Na+],,val
US20050165072A1,Clc1ccccc1Br.O=Cc1ccc(B(O)O)cc1>>O=Cc1ccc(-c2ccccc2Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20160235757A1,C#Cc1cccc(Nc2ncnc3cc4c(cc23)OCCOCCOCCO4)c1>>C#Cc1cccc(Nc2ncnc3cc4c(cc23)OCCOCCOCCO4)c1,,CCO,O,Cl,[Na+].[OH-],val
US20140296208A1,COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Oc4ccccc4)c4ccccc34)n2)cc(OC)c1.COc1c(N)cc(C(C)(C)C)cc1C(=O)N(C)C>>COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(C(=O)N(C)C)c4OC)c4ccccc34)n2)cc(OC)c1,,C1CCOC1,,,,val
US20100125062A1,Cc1cccnc1F.Nc1ccc(O)cc1>>Cc1cccnc1Oc1ccc(N)cc1,,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050272721A1,Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1.O=S(=O)(O)O>>Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1.O=S(=O)([O-])O,,CC(C)=O,,,,val
US03993683,CC(c1ccc(-c2ccccc2F)cc1)S(=O)CC(=O)O.CCCCBr>>CCCCOC(=O)CS(=O)C(C)c1ccc(-c2ccccc2F)cc1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20160145247A1,CCOc1cc(COc2ccccc2CC(=O)OC(C)(C)C)cc(-c2cccc([C@@H](C)NC(=O)OC(C)(C)C)c2F)c1>>CCOc1cc(COc2ccccc2CC(=O)O)cc(-c2cccc([C@@H](C)N)c2F)c1,,C1COCCO1,ClCCl,Cl,,val
US20070037796A1,ClCCl.NCCNS(=O)(=O)c1cc(-c2cccc(C(F)F)c2)cc2cnccc12.O=CCCc1ccc([N+](=O)[O-])cc1>>Cl.Cl.O=[N+]([O-])c1ccc(CCCNCCNS(=O)(=O)c2cc(-c3cccc(C(F)F)c3)cc3cnccc23)cc1,,CO,,[BH4-].[Na+],,val
US20160264567A1,C[C@@H]1N[C@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)ncc2C(F)F)C[C@H]1F.O=S(=O)(Cl)c1ccc(F)cc1>>C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)ncc2C(F)F)N1S(=O)(=O)c1ccc(F)cc1,,ClCCl,,CCN(CC)CC,,val
US20140336166A1,C[C@@H]1COCCN1.Clc1nc(Cl)c2nc[nH]c2n1>>C[C@@H]1COCCN1c1nc(Cl)nc2[nH]cnc12,,CC(C)O,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20050080074A1,CC(C)(C)OC(=O)N1CCN2C(=O)c3c(OC(F)(F)F)cc(OS(=O)(=O)C(F)(F)F)cc3C2C1.CC1(C)OB(C2CC2)OC1(C)C>>CC(C)(C)OC(=O)N1CCN2C(=O)c3c(OC(F)(F)F)cc(C4CC4)cc3C2C1,,COCCOC,,O,O=C([O-])[O-].[K+].[K+],val
US20090274632A1,COC(=O)c1ccc(CBr)cc1.COc1ccccc1CNS(=O)(=O)c1ccc(OC(C)=O)cc1>>COC(=O)c1ccc(CN(Cc2ccccc2OC)S(=O)(=O)c2ccc(OC(C)=O)cc2)cc1,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06307056B1,COc1ccc(C(=O)Cl)cc1.Nc1cccc(-c2cccc3c2/C(=C/c2ccc[nH]2)C(=O)N3)c1>>COc1ccc(C(=O)Nc2cccc(-c3cccc4c3/C(=C/c3ccc[nH]3)C(=O)N4)c2)cc1,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US20130261100A1,COC(=O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3N3CC(N(C)c4ccc(F)cc4C)C3)CC2)cc1>>Cc1cc(F)ccc1N(C)C1CN(c2ncc(Cl)cc2C(=O)NC2(c3ccc(C(=O)O)cc3)CC2)C1,,C1COCCO1,O,[Na+].[OH-],,val
US20130116234A1,CCOC(=O)c1c(NC)nc2c(F)cc(Cl)cc2c1Cc1ccccc1Cl>>CNc1nc2c(F)cc(Cl)cc2c(Cc2ccccc2Cl)c1C(=O)O,,CCO,,[Na+].[OH-],,val
US05276039,C=C1CCc2sccc2C1=O.NN>>c1cc2c(s1)CCC1CNN=C21,,O,,CCO,,val
US04160835,ClP(Cl)(Cl)(Cl)Cl.N#Cc1cc(CO)ccn1>>N#Cc1cc(Cl)ccn1,,c1ccccc1,,O,O=C([O-])O.[Na+],val
US20150344481A1,CC(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)ncn3C3CCOCC3)ccc2n1>>Nc1cn2nc(-c3c(-c4ccc(F)cc4)ncn3C3CCOCC3)ccc2n1,,CO,,C1COCCO1,Cl,val
US20130211075A1,CCOC(=O)c1cnn(-c2ncc(Cl)cc2F)c1C>>Cc1c(C(=O)O)cnn1-c1ncc(Cl)cc1F,,C1CCOC1,,O,[Na+].[OH-],val
US06184225B2,COc1cc2ncnc(Cl)c2cc1OC.Cl.Nc1cc(O)c(Br)cc1F>>COc1cc2ncnc(Nc3cc(O)c(Cl)cc3F)c2cc1OC.Cl,,CC(C)O,,,,val
US20110166161A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](Nc2nc(Cl)c(C#N)cc2F)CC1.CN>>CNc1nc(N[C@@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)c(F)cc1C#N,,C1CCOC1,,,,val
US05644028,C=O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(S)[C@H](N)C(=O)O>>CC(C)(C)OC(=O)N1CSC(C)(C)[C@H]1C(=O)O,,C1CCOC1,O,CCN(CC)CC,,val
US20160120841A1,CC(C)(C)OC(=O)N1CCC2(CC1)CC(=O)c1ccc(F)cc1O2>>CC(C)(C)OC(=O)N1CCC2(CC1)CC(O)c1ccc(F)cc1O2,,CO,,[BH4-].[Na+],,val
US20070254940A1,COC(Cc1cc(Br)ccc1NC1CC2CCC(C1)N2C)OC>>CN1C2CCC1CC(n1ccc3cc(Br)ccc31)C2,,CO,Cl,,,val
US20130184274A1,COC(=O)c1ccc2ccccc2n1>>O=C(O)c1ccc2ccccc2n1,,CO,O,[Li+].[OH-],,val
US20120172357A1,CC(C)(O)CC1(c2ccccc2)CCN(C(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)C2CC2)C(=O)O1.Cn1ccc(Br)cc1=O>>Cn1ccc(-c2ccc(C(C3CC3)N3CCC(CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cc1=O,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20150214492A1,Brc1ccc2c(c1)c1cc3c4ccccc4c4ccccc4c3cc1n2-c1ccccc1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC1(C)OB(c2ccc3c(c2)c2cc4c5ccccc5c5ccccc5c4cc2n3-c2ccccc2)OC1(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,CC(=O)[O-].[K+],,val
US04492692,O=C(CBr)Cc1ccc([N+](=O)[O-])cc1.O=C1NC(=O)c2ccccc21>>O=C(Cc1ccc([N+](=O)[O-])cc1)CN1C(=O)c2ccccc2C1=O,,Cc1ccccc1,,[K],,val
US20100216769A1,C=CC(=O)OC.C=CCOC[C@@](C)(NC(=O)OC(C)(C)C)C(=O)Nc1ccc2c(c1)CCN(C)CC2>>COC(=O)C=CCOC[C@@](C)(NC(=O)OC(C)(C)C)C(=O)Nc1ccc2c(c1)CCN(C)CC2,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,ClCCl,,,,val
US20100292143A1,COC(=O)c1cc(C(=O)C(C)C)c[nH]1.Fc1ccc(CBr)cc1F>>COC(=O)c1cc(C(=O)C(C)C)cn1Cc1ccc(F)c(F)c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110201605A1,Cc1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)c2nc(N)nn2c1.Cc1cc(N2CCC(=O)CC2)ncn1>>Cc1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)c2nc(NC3CCN(c4cc(C)ncn4)CC3)nn2c1,,CO,ClCCl,,,val
US20020049197A1,CC(C)(C)OC(=O)N1CCNCC1.Fc1ccc(Nc2ncnc3cc(OCCBr)c(OC4CCCC4)cc23)cc1Cl>>CC(C)(C)OC(=O)N1CCN(CCOc2cc3ncnc(Nc4ccc(F)c(Cl)c4)c3cc2OC2CCCC2)CC1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US05236952,CC(=O)OC(C)=O.COc1ccc(C=O)c(Cl)c1O>>COc1ccc(C=O)c(Cl)c1OC(C)=O,,c1ccncc1,,,,val
US20130053366A1,COc1ccc(C(O)Cn2c3c(c4cc(C)ccc42)CN(C)CC3)cn1>>Cc1ccc2c(c1)c1c(n2CC(O)c2ccc(=O)[nH]c2)CCN(C)C1,,Cl,,,,val
US20050186444A1,Clc1ccccc1Cl.Ic1ccc(I)cc1.c1ccc(Nc2ccccc2)cc1>>Ic1ccc(N(c2ccccc2)c2ccccc2)cc1,[Cu],Clc1ccccc1Cl,,O=C([O-])[O-].[K+].[K+],,val
US20100298321A1,COc1ccc(CN(Cc2ccc(OC)cc2OC)S(=O)(=O)c2ccc(OCC3(F)CCN(C4COC4)CC3)c(Cl)c2)c(OC)c1>>NS(=O)(=O)c1ccc(OCC2(F)CCN(C3COC3)CC2)c(Cl)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070265272A1,CC(N)c1ccc2ncccc2c1.Nc1ncc(Br)nc1Br>>CC(Nc1nc(Br)cnc1N)c1ccc2ncccc2c1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US06551682B1,Cc1cnc(C)c(Cl)n1.NN>>Cc1cnc(C)c(NN)n1,,CCO,,O,,val
US20030114671A1,CC(=O)C(=O)O.CCC(CC)Oc1nc(C)nc(Nc2c(C)cc(C)cc2C)c1N>>CCC(CC)Oc1nc(C)nc2c1nc(C)c(=O)n2-c1c(C)cc(C)cc1C,,CCO,,,,val
US20090054413A1,Cc1nn(C2CCCC2)c(N)c1C(=O)On1nnc2cccnc21.NCC(=O)c1ccccc1>>Cc1nn(C2CCCC2)c2c1C(=O)NCC(c1ccccc1)=N2,,C1CCOC1,,CCN(CC)CC,Cl,val
US04314065,BrBr.CSc1nc2ccccc2o1>>CSc1nc2ccc(Br)cc2o1,,ClC(Cl)Cl,,,,val
US20060106029A1,CC(C)(C)[Si](C)(C)OCc1cccc(Br)n1.Nc1nccs1>>CC(C)(C)[Si](C)(C)OCc1cccc(Nc2nccs2)n1,,C1COCCO1,CCOC(C)=O,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20080113978A1,CCC(CC)c1cc(C)nn2c(-c3ocnc3C)c(C)nc12.O=C1CCC(=O)N1Br>>CCC(CC)c1cc(C)nn2c(-c3oc(Br)nc3C)c(C)nc12,,ClCCl,,,,val
US20100144757A1,C#C[Si](C)(C)C.COCC(=O)N(C)OC>>COCC(=O)C#C[Si](C)(C)C,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US04772600,C1COCCN1.O=C(O)Cn1c(-c2ccc(Cl)cc2)nc2cccnc21>>O=C(Cn1c(-c2ccc(Cl)cc2)nc2cccnc21)N1CCOCC1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20120245137A1,NCc1ccccc1.O=C1CCC(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1>>O=S(=O)(c1cccc(C(F)(F)F)c1)C1CCC(NCc2ccccc2)CC1,,ClCCCl,,CC(=O)O,,val
US20110184015A1,Nc1ccc(F)cc1N.O=C(O)c1cccc2c1-n1cccc1C2=O>>Nc1cc(F)ccc1NC(=O)c1cccc2c1-n1cccc1C2=O,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060264415A1,COc1cc(NS(=O)(=O)c2ccc(C#CCNC(=O)COCc3ccc(F)cc3)cc2)ccc1NC(=O)OC(C)(C)C>>COc1cc(NS(=O)(=O)c2ccc(CCCNC(=O)COCc3ccc(F)cc3)cc2)ccc1NC(=O)OC(C)(C)C,[Pd],CO,,,,val
US20060258691A1,CC(C)(C)NN.CC(C)(C)OC(=O)C(=O)c1ccc(F)nc1F>>CC(C)(C)NN=C(C(=O)OC(C)(C)C)c1ccc(F)nc1F,,CCO,,CCN(CC)CC,,val
US20100286161A1,CC(=O)OC(C)=O.Cc1cc(C)n(-c2cnc(CN)c(Nc3ccc(Cl)cc3)n2)n1>>CC(=O)NCc1ncc(-n2nc(C)cc2C)nc1Nc1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20140155433A1,CI.COC(=O)c1cc(C)c(-c2ccc(OC)c(Br)c2)[nH]1>>COC(=O)c1cc(C)c(-c2ccc(OC)c(Br)c2)n1C,,CN(C)C=O,,[H-].[Na+],,val
US04450167,CCOC(=O)c1c(C)nc2ccccc2c1O.COc1ccc(N)cc1>>COc1ccc(NC(=O)c2c(C)nc3ccccc3c2O)cc1,,Cc1ccccc1C,,,,val
US20090275618A1,CC(C)(N)c1ccc(C(F)(F)F)nc1.Cc1ccc(S(=O)(=O)O)cc1>>CC(C)(N)c1ccc(C(F)(F)F)nc1.Cc1ccc(S(=O)(=O)O)cc1,,C1CCOC1,COC(C)(C)C,O,,val
US20080070920A1,CC(C)(C)c1c(Cl)nc(OCc2ccccc2)nc1OCc1ccccc1.Cc1cc(C#N)cc(CC#N)c1>>Cc1cc(C#N)cc(C(C#N)c2nc(OCc3ccccc3)nc(OCc3ccccc3)c2C(C)(C)C)c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US03981932,CCOC(=O)C(=O)c1ccc(C2CCCCC2)c([N+](=O)[O-])c1>>CCOC(=O)C(=O)c1ccc(C2CCCCC2)c(N)c1,[Pd],,,CO,[H][H],val
US20080139505A1,CC(=O)c1ccc(OCc2ccc(C(OC3CCCCO3)c3cccc(C#N)c3)cc2)c(C)c1O.O.[OH-]>>CC(=O)c1ccc(OCc2ccc(C(OC3CCCCO3)c3cccc(C(=O)O)c3)cc2)c(C)c1O,,CCO,,Cl,,val
US04188491,CC(C)CCCCCOC(=O)c1ccccc1C(=O)OCCCCCC(C)C.O=C1CCCC1.c1ccc(P(CC2OC3(CCCC3)OC2CP(c2ccccc2)c2ccccc2)c2ccccc2)cc1>>CCOC(=O)C1OC2(CCCC2)OC1C(=O)OCC,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04643990,CCCCCCCCCCCCCCCC(=O)CC(=O)OC(C)(C)C>>CCCCCCCCCCCCCCCC(O)CC(=O)OC(C)(C)C,,CO,,[BH4-].[Na+],,val
US04761420,CC(=O)OC(C)=O.COC(=O)C1=C(C)NC(C)=C(C(=O)OCCOc2ccc(CCO)cc2)C1c1cccc([N+](=O)[O-])c1>>COC(=O)C1=C(C)NC(C)=C(C(=O)OCCOc2ccc(CCOC(C)=O)cc2)C1c1cccc([N+](=O)[O-])c1,,ClCCl,,O,c1ccncc1,val
US20090093483A1,COC(=O)C(C)(C)c1ccc(Cl)cc1F>>CC(C)(C(=O)O)c1ccc(Cl)cc1F,,CCO,CCOCC,[K+].[OH-],,val
US20100022650A1,CCOC(=O)Cc1ccc(NC(=O)c2cc(NCc3ccccc3)ccc2Cl)cc1>>O=C(O)Cc1ccc(NC(=O)c2cc(NCc3ccccc3)ccc2Cl)cc1,,CC(=O)O,Cl,O,,val
US20100210635A1,CC(=O)OC(C)=O.COC(=O)C=Cc1ccccc1Cc1ccccc1CC#N>>COC(=O)CCc1ccccc1Cc1ccccc1CCNC(C)=O,[Ni],,,,,val
US20020035258A1,CON=C1CN(Cc2ccccc2)CC12CN(C)C2>>CON=C1CNCC12CN(C)C2,[Pd],CO,,[H][H],,val
US20040058978A1,CC(=O)N1C(=O)C(=C(Cl)c2ccc(C)cc2)c2cc([N+](=O)[O-])ccc21.CN(C)Cc1ccc(N)cc1>>Cc1ccc(/C(Nc2ccc(CN(C)C)cc2)=C2/C(=O)Nc3ccc([N+](=O)[O-])cc32)cc1,,CN(C)C=O,CO,[Na+].[OH-],,val
US20070299130A1,CC1(C)Oc2cc(NS(C)(=O)=O)ccc2[C@H](NCCc2ccccc2)[C@H]1O.O=C(O)/C=C\C(=O)O>>CC1(C)Oc2cc(NS(C)(=O)=O)ccc2[C@H](NCCc2ccccc2)[C@H]1O.O=C(O)/C=C\C(=O)O,,CCO,,,,val
US05968938,COC(=O)Cc1ccc(NC(=O)OC(C)(C)C)cc1OCC(F)(F)F>>CC(C)(C)OC(=O)Nc1ccc(CC(=O)O)c(OCC(F)(F)F)c1,,CO,,[Na+].[OH-],,val
US05118816,CCOC(=O)C(F)(F)F.NC(C(=O)O)c1ccccc1>>O=C(O)C(NC(=O)C(F)(F)F)c1ccccc1,,CO,,CCN(CC)CC,,val
US20120015962A1,C1CCNCC1.CCOC(=O)Cc1cc(Cl)c([N+](=O)[O-])cc1[N+](=O)[O-]>>CCOC(=O)Cc1cc(N2CCCCC2)c(N)cc1N,[Zn],ClCCl,,CC(=O)O,,val
US20040242613A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC1CCC(CN)CC1>>CC(C)(C)OC(=O)NCC1CCC(CNC(=O)OC(C)(C)C)CC1,,ClCCl,,,,val
US20100063115A1,N#Cc1cc(C(=O)O)ccc1F.NNC(=O)Cc1ccccc1>>N#Cc1cc(C(=O)NNC(=O)Cc2ccccc2)ccc1F,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US06362177B1,CC(C)(C)OC(=O)NCC(=O)NC1CCN(Cc2ccccc2)CC1.Cl>>NCC(=O)NC1CCN(Cc2ccc(Cl)cc2)CC1,,C1COCCO1,CO,,,val
US20100216788A1,CC(=O)c1cccc(O)c1.O=[N+]([O-])c1ccc(F)c(Cl)c1>>CC(=O)c1cccc(Oc2ccc([N+](=O)[O-])cc2Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04439604,CC(=O)OC(C)=O.O=c1[nH]cnc2c1ccn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O.c1ccncc1>>CC(=O)OC[C@H]1O[C@@H](n2ccc3c(=O)[nH]cnc32)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,CN(C)c1ccncc1,c1ccncc1,,,,val
US08476253B2,CN.CNCCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1.O=C(Cl)CCCCCBr>>CNCCCCCC(=O)N(C)CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1,,ClCCl,O,CCN(CC)CC,CO,val
US20070244117A1,O=c1[nH]c2ccccc2c(=O)o1.OCC1CCOCC1>>O=c1oc(=O)n(CC2CCOCC2)c2ccccc12,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100130497A1,CCCC#COc1ccc(C=O)cc1OC.O=C(O)CC(=O)Nc1ccccc1C(=O)O>>C#CCCCOc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1OC,,Cc1ccccc1,,C1CCNCC1,Cl,val
US20150112058A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.COC(=O)Nc1ccc(I)c([N+](=O)[O-])c1>>C=C(OCC)c1ccc(NC(=O)OC)cc1[N+](=O)[O-],Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,,,,val
US20080261990A1,Cc1ccc(Cc2cc(N(Cc3ccc(SC(C)(C)C(=O)OC(C)(C)C)cc3)Cc3ccco3)ncn2)cc1.Cl>>Cc1ccc(Cc2cc(N(Cc3ccc(SC(C)(C)C(=O)O)cc3)Cc3ccco3)ncn2)cc1.Cl,,C1COCCO1,,,,val
US20090156610A1,CS(=O)(=O)OC1CCCCC1.O=Cc1cc(Cl)ccc1O>>O=Cc1cc(Cl)ccc1OC1CCCCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080269213A1,Nc1cccc(C(NC(=O)COc2ccccc2)c2cc(Cl)c3cccnc3c2O)c1.O=C(Cl)CCl>>O=C(CCl)Nc1cccc(C(NC(=O)COc2ccccc2)c2cc(Cl)c3cccnc3c2O)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020099055A1,CC(C)CC=O.O=C(O)c1ccsc1>>CC(C)CC(=O)c1sccc1C(=O)O,,C1CCOC1,,O,CC(C)[N-]C(C)C.[Li+],val
US20040229876A1,COc1cc2nccc(Oc3ccc(N)cc3Cl)c2cc1OC.Cc1cc(N)on1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)no4)cc3Cl)c2cc1OC,,Clc1ccccc1,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US05246948,O=C1c2ccccc2C(=O)N1CCCOc1ccncc1>>O=C1c2ccccc2C(O)N1CCCOc1ccncc1,,CCO,,[BH4-].[Na+],,val
US20090247507A1,COc1ccc(C=O)cc1.Nc1ncc(Br)c(N2CCN(Cc3ccncc3)CC2)c1[N+](=O)[O-]>>COc1ccc(-c2nc3c(N4CCN(Cc5ccncc5)CC4)c(Br)cnc3[nH]2)cc1,,CCO,,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20150322045A1,CC(C)C1CNCCN1.O=C(OCc1ccccc1)ON1C(=O)CCC1=O>>CC(C)C1CN(C(=O)OCc2ccccc2)CCN1,,ClCCl,,,,val
US20160264575A1,CC(C)(C)OC(=O)N1Cc2[nH]c3ccccc3c2C(C)(C)C1C(=O)O.Fc1ccc(CBr)cc1>>CC(C)(C)OC(=O)N1Cc2c(c3ccccc3n2Cc2ccc(F)cc2)C(C)(C)C1C(=O)O,,CN(C)C=O,,[H-].[Na+],,val
US04024134,ClP(Cl)(Cl)(Cl)Cl.O=C(O)CC1C=CC=CC1=NOC(=O)C(Cl)Cl>>O=C(Cl)CC1C=CC=CC1=NOC(=O)C(Cl)Cl,,ClCCl,,,,val
US20030125370A1,Cc1[nH]c(C=O)c(C)c1C(=O)N1CCC[C@H]1CNC1CC1.O=C1Cc2cc(S(=O)(=O)Cc3ccccc3)ccc2N1>>Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4ccccc4)cc32)c(C)c1C(=O)N1CCC[C@H]1CNC1CC1,C1CCNCC1,CCO,,,,val
US20070054924A1,Cc1c(OC2CCN(C[C@H](O)CNC(=O)c3ccc(Cl)c(C(=O)OC(C)(C)C)c3)CC2)ccc(Cl)c1Cl>>Cc1c(OC2CCN(C[C@H](O)CNC(=O)c3ccc(Cl)c(C(=O)O)c3)CC2)ccc(Cl)c1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090192156A1,Cc1cccc(O)n1.O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCC(O)CC1>>Cc1cccc(OC2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)n1,,ClCCl,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05420129,COC(=O)C(Cl)C(=O)OC.COc1ccccc1S>>COC(=O)C(Sc1ccccc1OC)C(=O)OC,,CCO,,[K+].[OH-],,val
US20080081817A1,CC(C)(C)OC(=O)N1CCN(c2ncnc3[nH]ncc23)CC1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCN(c2ncnc3[nH]nc(Br)c23)CC1,,CN(C)C=O,,,,val
US20100204196A1,COc1cc(N2CCOC[C@@H]2C)ccc1Nc1nc(Nc2cc(F)cc(F)c2C(N)=O)c2ccn(S(=O)(=O)c3ccc(C)cc3)c2n1>>COc1cc(N2CCOC[C@@H]2C)ccc1Nc1nc(Nc2cc(F)cc(F)c2C(N)=O)c2ccnc-2[nH]1,,C1COCCO1,,[Na+].[OH-],,val
US20130303507A1,O=C(N[C@@H]1CC[C@@H](CN2CCOCC2)CC1)OCc1ccccc1>>N[C@@H]1CC[C@@H](CN2CCOCC2)CC1,[Pd],C1CCOC1,,CCO,,val
US20100125089A1,CC(N)(C#N)Cn1cc2c(Cl)cc(Cl)c(Cl)c2n1.O=C(Cl)c1ccc(Oc2ccccc2)cc1>>CC(C#N)(Cn1cc2c(Cl)cc(Cl)c(Cl)c2n1)NC(=O)c1ccc(Oc2ccccc2)cc1,,C1CCOC1,,,,val
US20090186869A1,CC(C)(OC(=O)Oc1ccc([N+](=O)[O-])cc1)C(F)(F)F.N[C@H](C(=O)O)C1CC1>>CC(C)(OC(=O)NC(C(=O)O)C1CC1)C(F)(F)F,,CC#N,CO,CCN(C(C)C)C(C)C,O,val
US20150065482A1,COC(=O)c1nn(-c2cc(C#C[C@]3(O)CCN(C)C3=O)cc(C(F)(F)F)c2)c2ncccc12.N>>CN1CC[C@@](O)(C#Cc2cc(-n3nc(C(N)=O)c4cccnc43)cc(C(F)(F)F)c2)C1=O,,CO,,,,val
US20090306043A1,CC(O)C1CNCC1c1ccc(Cl)c(Cl)c1.N#Cc1ccc(O)nc1.O=C(/N=N/C(=O)OCc1ccccc1)OCc1ccccc1>>CC(Oc1ccc(C#N)cn1)C1CN(Cc2ccccc2)CC1c1ccc(Cl)c(Cl)c1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05374638,CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(CCc1ccccc1)C(=O)OCC>>CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(CCc1ccccc1)C(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20070191612A1,C=CCCl.C=CCn1ccnc1>>C=CCn1cc[n+](CC=C)c1.[Cl-],,CC#N,,Cc1ccccc1,,val
US20160221972A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1NCCOc2ccc(Br)cc21>>CC1c2cc(Br)ccc2OCCN1C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20140057945A1,O=C(Cl)C1CCCCC1.O=C(Cn1nc(C(F)F)cc1C(F)F)N1CCC(c2nc(C3=NOC(c4ccccc4O)C3)cs2)CC1>>O=C(Oc1ccccc1C1CC(c2csc(C3CCN(C(=O)Cn4nc(C(F)F)cc4C(F)F)CC3)n2)=NO1)C1CCCCC1,,ClCCl,,CCN(CC)CC,,val
US04971957,CCOP(=O)(Cc1ccc(C(=O)Cl)cc1)OCC.c1ccc2c(c1)CCN2>>CCOP(=O)(Cc1ccc(C(=O)N2CCc3ccccc32)cc1)OCC,CN(C)c1ccncc1,CC(Cl)Cl,O,CCN(CC)CC,ClCCl,val
US20090192156A1,CCOC1CCNCC1.O=C(O)c1cc(Cc2n[nH]c(=O)c3cccc(Cl)c23)ccc1F>>CCOC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4cccc(Cl)c34)ccc2F)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20100240658A1,Cc1ccccc1-c1ccc(C(=O)O)cc1C.O=C(Cl)C(=O)Cl>>Cc1ccccc1-c1ccc(C(=O)Cl)cc1C,,ClCCl,,CN(C)C=O,,val
US20100191019A1,C=CC[Mg]Br.CCCC/C=C/C=C/C=O>>C=CCC(O)/C=C/C=C/CCC,,CCOCC,,[Cl-].[NH4+],,val
US20030149043A1,CCOC(=O)c1cnn(-c2cc(S(=O)(=O)O)ccc2Cl)c1C1CC1.O=P(Cl)(Cl)Cl>>CCOC(=O)c1cnn(-c2cc(S(=O)(=O)Cl)ccc2Cl)c1C1CC1,,O=P(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20160052912A1,CCOc1cc(F)c(Cn2nc(C(=O)OC)c3ccccc32)c(F)c1.N=C(N)NC(=N)N>>CCOc1cc(F)c(Cn2nc(-c3nc(N)nc(N)n3)c3ccccc32)c(F)c1,,CO,,Cl,C[O-].[Na+],val
US04007176,CCOC(=O)CC(=O)CBr.OCCS>>CCOC(=O)CC1=CSCCO1,,CCO,,C,C[O-].[Na+],val
US04060633,BrP(Br)Br.CC(O)(CCO)c1ccc(-c2ccc(F)cc2)cc1>>CC(O)(CCBr)c1ccc(-c2ccc(F)cc2)cc1,,c1ccccc1,,c1ccncc1,,val
US20110263561A1,Clc1ncnc2nc[nH]c12.F[C@@H]1CN[C@@H](COc2ccccc2Cl)C1>>F[C@H]1C[C@H](COc2ccccc2Cl)N(c2ncnc3[nH]cnc23)C1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20050080074A1,C#Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCN(C(=O)OC(C)(C)C)C[C@@H]21.Cl>>C#Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21.Cl,,CCOCC,O,,,val
US05416211,BrBr.COC(=O)c1ccc(CCC=CO[Si](C)(C)C)cc1>>COC(=O)c1ccc(CCC(Br)C=O)cc1,,ClC(Cl)(Cl)Cl,,,,val
US20080125470A1,CCOC(=O)C1(c2csc(NC)n2)C=CON1>>CNc1nc(C2(C(=O)O)C=CON2)cs1,,CCO,,Cl,[Na+].[OH-],val
US20120142937A1,C[Si](C)(C)N1CCCC1.N#Cc1ccc(F)cc1>>N#Cc1ccc(N2CCCC2)cc1,,CN(C)C=O,ClCCl,O,[Cs+].[F-],val
US20090093497A1,CCOC(=O)C(C)(C)C1CCN(c2ccc([N+](=O)[O-])cn2)CC1>>CC(C)(C(=O)O)C1CCN(c2ccc([N+](=O)[O-])cn2)CC1,,C1CCOC1,CO,[Na+].[OH-],,val
US20130137688A1,Cc1cc(-c2cc(-c3ccccc3)n(CC(=O)O)n2)ccc1F.c1cnc(N2CCNCC2)nc1>>Cc1cc(-c2cc(-c3ccccc3)n(CC(=O)N3CCN(c4ncccn4)CC3)n2)ccc1F,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,O=C([O-])[O-].[K+].[K+],val
US20050038043A1,CCCc1c(CBr)ncn2ncnc12.N#Cc1cccnc1-c1ncc[nH]1>>CCCc1c(Cn2ccnc2-c2ncccc2C#N)ncn2ncnc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080176881A1,CC(C)Oc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)C(=O)N(C1CCNCC1)C2.NC(=O)CBr>>CC(C)Oc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)C(=O)N(C1CCN(CC(N)=O)CC1)C2,,CN(C)C=O,,CCN(CC)CC,,val
US20140031336A1,CC(=O)N1c2ccc(-c3ccc(C(=O)O)cn3)cc2[C@H](Nc2ccc(C#N)cn2)C[C@@H]1C.NCCO>>CC(=O)N1c2ccc(-c3ccc(C(=O)NCCO)cn3)cc2[C@H](Nc2ccc(C#N)cn2)C[C@@H]1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070060629A1,Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccccc2)cc1S(=O)(=O)Cl.N>>Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccccc2)cc1S(N)(=O)=O,,C1CCOC1,,CCOC(C)=O,O,val
US20100056510A1,CC(C)(C)OC(=O)NCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N1CCOCC1>>CC(C)(C)OC(=O)NCC[C@H](N)C(=O)N1CCOCC1,,CN(C)C=O,,C1CCNCC1,,val
US05017573,CN1CCN(Cc2ccccc2)CC(NC(=O)c2n[nH]c3ccccc23)C1.COC(=O)Cl>>COC(=O)n1nc(C(=O)NC2CN(C)CCN(Cc3ccccc3)C2)c2ccccc21,,ClCCl,,CCN(CC)CC,,val
US20060178416A1,Nc1c(Cl)ccc2c1C(=O)CO2.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C1COc2ccc(Cl)c(NC(=O)C(F)(F)F)c21,,ClCCl,,CCN(CC)CC,,val
US20160272628A1,CSCCN1C(C)c2cc(Br)ccc2S1(=O)=O.O=C(OO)c1cccc(Cl)c1>>CC1c2cc(Br)ccc2S(=O)(=O)N1CCS(C)=O,,ClCCl,,,,val
US04640913,CCCCCCCCCCCCCCCCCC(=O)Cl.CCOC(C)=O.O>>CCCCCCCCCCCCCCCCCC(=O)CO,,CCOC(C)=O,,C1CCOC1,Cl,val
US20050043544A1,CCOC(C)=O.COc1c(C=O)cc(C(C)(C)C)cc1C(C)(C)C>>CCOC(=O)CC(O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1OC,,C1CCOC1,C1CCOC1,Cl,,val
US05496843,COC(=O)c1[nH]c2cc(Cl)cc3c2c1C(CC(=O)OC(C)(C)C)CC3>>COC(=O)c1[nH]c2cc(Cl)cc3c2c1C(CC(=O)O)CC3,,CCOC(C)=O,Cc1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,,val
US04883806,C#CCN1CC(=O)N(CO)C1=O.CC1(C)C(/C=C\C(=O)OCC(F)F)C1C(=O)O>>C#CCN1CC(=O)N(COC(=O)[C@@H]2[C@H](/C=C\C(=O)OCC(F)F)C2(C)C)C1=O,,ClC(Cl)Cl,,,,val
US20150353498A1,CCOC(=O)CC(=O)O.O=C1Cc2cc(Br)ccc2C(=O)O1>>CCOC(=O)Cc1cc2cc(Br)ccc2c(=O)o1,,C1CCOC1,Cl,CCN(C(C)C)C(C)C,,val
US04207320,C1CCNC1.Cc1ccc(S(=O)(=O)[O-])cc1.Fc1ccc2c(ccc3n4c(ccc5ccccc54)c[n+]23)c1>>Cc1ccc(S(=O)(=O)[O-])cc1.c1ccc2c(c1)ccc1c[n+]3c4ccc(N5CCCC5)cc4ccc3n12,,CN1CCCC1=O,,,,val
US20070249670A1,Cc1ccc(N)c(C(=O)O)c1.Cc1cccc(C)c1N=C=O>>Cc1ccc(NC(=O)Nc2c(C)cccc2C)c(C(=O)O)c1,,CN(C)C=O,O,CCN(CC)CC,Cl,val
US20070060754A1,CC(C)CNc1c(N)cnc2cc(OCc3ccccc3)ccc12.CCCC(OC)(OC)OC>>CCCc1nc2cnc3cc(OCc4ccccc4)ccc3c2n1CC(C)C,,Cc1ccccc1,,Cl,c1ccncc1,val
US20080214448A1,COc1ccccc1C=O.NO>>COc1ccccc1C=NO,,CCO,O,Cl,[Na+].[OH-],val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3[nH]c(C(F)(F)F)nc3c2)cc1.Cl>>Cc1cc(C(=O)NC2CCN(C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc3[nH]c(C(F)(F)F)nc3c2)cc1.Cl,,C1COCCO1,,,,val
US20110269758A1,COC(=O)c1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2[nH]c1=O>>O=C(Nc1ccc(Nc2ncnc3[nH]c(=O)c(C(=O)O)cc23)cc1)c1ccccc1,,C1CCOC1,CO,[Na+].[OH-],,val
US04732998,CCOP(=O)(OCC)C(OCCCN1C(=O)c2ccccc2C1=O)P(=O)(OCC)OCC>>NCCCOC(P(=O)(O)O)P(=O)(O)O,,O,,Cl,,val
US20090036443A1,COC(=O)c1cc2[nH]c(-c3ccc(Cl)cc3)c(C3CCCCC3)c2s1.COCCl>>COCn1c(-c2ccc(Cl)cc2)c(C2CCCCC2)c2sc(C(=O)OC)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20110237784A1,BrCc1ccccc1.Oc1ccc2ccccc2c1O>>Oc1ccc2ccccc2c1OCc1ccccc1,,CC(C)=O,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],val
US20160068545A1,C=CCCBr.CCS(=O)(=O)N(Cc1ccc(OC)cc1)Cc1ccc(OC)cc1>>C=CCC[C@@H](C)S(N)(=O)=O,,C1CCOC1,,[Li]CCCC,,val
US20020090728A1,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)F.NCCS>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)NCCS,,ClCCl,O,Cl,O=C([O-])O.[Na+],val
US20060122168A1,CC(C)(C)OC(=O)N[C@@H](COc1ccc(F)cc1[N+](=O)[O-])C(=O)O>>CC(C)(C)OC(=O)N[C@@H](COc1ccc(F)cc1N)C(=O)O,[Pd],CO,,ClCCl,,val
US20080045493A1,CCCN1CC(c2ccc(N)cc2)C1.O=S(=O)(Cl)c1ccc(Br)cc1>>CCCN1CC(c2ccc(NS(=O)(=O)c3ccc(Br)cc3)cc2)C1,,ClCCl,c1ccncc1,,,val
US04808584,CC(=O)OCC(=O)CCl.CCOC(=O)C(C(=O)OCC)=C(S)Nc1ccc(F)c(F)c1F>>CCOC(=O)C(C(=O)OCC)=C(Nc1ccc(F)c(F)c1F)SCC(=O)COC(C)=O,,CN(C)C=O,,[Na],,val
US20060211603A1,CO.O=C(O)c1cc2ccccc2[nH]1>>COC(=O)c1cc2ccccc2[nH]1,O=S(=O)(O)O,,,,,val
US20090227625A1,COc1c(C(=O)O)cc(F)c2ccccc12>>O=C(O)c1cc(F)c2ccccc2c1O,,CC(=O)O,,,,val
US04187305,N.Nc1nc(Cl)nc(NC2CC2)n1>>Nc1nc(N)nc(NC2CC2)n1,,C1COCCO1,,,,val
US20120149737A1,COC(=O)c1ccc(N)cc1.O=C(O)c1cc(Cl)c(OC2CCCC2)c(Cl)c1>>COC(=O)c1ccc(NC(=O)c2cc(Cl)c(OC3CCCC3)c(Cl)c2)cc1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20130079343A1,CC(C)(C)OC(=O)Oc1ccc(-c2cn(-c3ccncc3)c3cc(N4CCN(C(=O)OC(C)(C)C)CC4)ccc23)cc1>>CC(C)(C)OC(=O)N1CCN(c2ccc3c(-c4ccc(O)cc4)cn(-c4ccncc4)c3c2)CC1,,CO,,O,[Na+].[OH-],val
US20110059034A1,CCCCC1CO1.O=C1O[C@H]([C@@H](O)CO)C(O)=C1O>>CCCCC(O)COC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO,,CN(C)C=O,,,,val
US05019568,CC(=O)OC[C@H]1O[C@H](S)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OCCCCCCI)CC[C@]4(C)[C@H]3CC[C@]12C>>CC(=O)OC[C@H]1O[C@@H](SCCCCCCO[C@H]2CC[C@@]3(C)C(=CC[C@H]4[C@@H]5CC[C@H]([C@H](C)CCCC(C)C)[C@@]5(C)CC[C@@H]43)C2)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,ClCCl,,CCN(CC)CC,,val
US20010009962A1,CCc1n[nH]c(C(N)=O)c1[N+](=O)[O-].ClCc1ccccn1>>CCc1nn(Cc2ccccn2)c(C(N)=O)c1[N+](=O)[O-],,CC#N,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04678781,Brc1nccs1.C[O+](C)C.F[B-](F)(F)F>>C[n+]1ccsc1Br.F[B-](F)(F)F,,ClCCl,,,,val
US20130225646A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC(CO)c1ccccc1C(F)(F)F>>CC(C)(C)OC(=O)NCC(CO)c1ccccc1C(F)(F)F,,C1COCCO1,,Cl,O=C([O-])O.[Na+],val
US05180419,CCOC(=O)c1cc(O)c([N+](=O)[O-])cc1C(=O)OCC>>CCOC(=O)c1cc(N)c(O)cc1C(=O)OCC,[Pd],CCO,,,,val
US20120196894A1,O=C[C@@H]1CCC=C2CCCO[C@@H]21>>OC[C@@H]1CCC=C2CCCO[C@@H]21,,CO,,[BH4-].[Na+],,val
US20040138462A1,COC(=O)c1ccc(B(O)O)cc1.O=C(NCCc1ccc(S(=O)(=O)c2ccc(OS(=O)(=O)C(F)(F)F)c(Cl)c2)cc1)C(F)(F)F>>COC(=O)c1ccc(-c2ccc(S(=O)(=O)c3ccc(CCNC(=O)C(F)(F)F)cc3)cc2Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O=C([O-])[O-].[Na+].[Na+],,val
US20160122342A1,C=CCc1c(C(=O)NCc2c(CN(C)CC=C)cc(C)nc2OC)cccc1N(CC)C1CCOCC1>>CCN(c1cccc2c1CC=CCN(C)Cc1cc(C)nc(OC)c1CNC2=O)C1CCOCC1,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,ClCCl,,,,val
US20100292207A1,Nc1n[nH]c2ccc(C(=O)c3cc(F)cc(F)c3)cc12.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(c1cc(F)cc(F)c1)c1ccc2[nH]nc(NC(=O)C(F)(F)F)c2c1,,C1CCOC1,,,,val
US20090209524A1,CCCCCNc1nc(N)nc(C)c1Cc1ccc(CO)cc1.O=S(Cl)Cl>>CCCCCNc1nc(N)nc(C)c1Cc1ccc(CCl)cc1,,ClCCl,,,,val
US20160052951A1,C=CC[Mg]Br.CC[C@@H](O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)[C@@]1(C)OC(=O)N(CCCCN=[N+]=[N-])[C@@H]1/C=N/[S@@](=O)C(C)(C)C>>C=CC[C@@H](N)[C@H]1N(CCCCN=[N+]=[N-])C(=O)O[C@]1(C)[C@@H](CC)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,CCOC(C)=O,ClCCl,Cl,[Cl-].[NH4+],val
US20120252801A1,CCNC[C@H](O)c1ccccc1.O=CC=O>>CCN1CC(=O)O[C@H](c2ccccc2)C1,,Cc1ccccc1,,,,val
US20020072518A1,CC(C)(C)OC(=O)Nc1cccc(CCO)n1.O=C(O)CC1CCc2cc(OCCCNc3ccccn3)ccc2C1>>CCOC(=O)CC1CCc2cc(OCCc3cccc(NC(=O)OC(C)(C)C)n3)ccc2C1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04816582,CCOC(=O)/C(=N\OCC(=O)N1CCCCCC1)c1csc(N)n1>>Nc1nc(/C(=N/OCC(=O)N2CCCCCC2)C(=O)O)cs1,,CO,,O,[Na+].[OH-],val
US20120059001A1,Nc1ncnc2c1c(C#CCO)nn2Cc1oc2ccccc2c(=O)c1-c1ccccc1>>Nc1ncnc2c1c(CCCO)nn2Cc1oc2ccccc2c(=O)c1-c1ccccc1,[Pd],CO,,ClCCl,,val
US04990517,CCOC(=O)Cl.COC(OC)C(C)N>>CCOC(=O)NC(C)C(OC)OC,,Cc1ccccc1,O,[Na+].[OH-],,val
US04863904,C=O.CC(C)C[C@@H](C=NNC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(CCCCc1ccccc1)Cc1cccc2ccccc12>>CC(C)C[C@@H](C=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(CCCCc1ccccc1)Cc1cccc2ccccc12,,CO,,Cl,O=C([O-])O.[Na+],val
US05219862,CCCN1C[C@H](CC#N)C[C@@H]2c3cccc4[nH]c(COC)c(c34)C[C@H]21>>CCCN1C[C@H](CC#N)C[C@@H]2c3cccc4[nH]c(C)c(c34)C[C@H]21,,ClC(Cl)Cl,,,,val
US20130053565A1,CC(C)(C)OC(=O)N1CC(=O)C1.CCCC[Sn](C#Cc1ccccc1)(CCCC)CCCC>>CCCC[Sn](CCCC)(CCCC)C1=C(c2ccccc2)C(=O)CN(C(=O)OC(C)(C)C)C1,,Cc1ccccc1,,,,val
US20060135552A1,CC(=O)CC(C)=O.Nc1sc(-c2ccccc2)cc1C(=O)c1ccccc1>>CC(=O)c1c(C)nc2sc(-c3ccccc3)cc2c1-c1ccccc1,O=S(=O)(O)O,CC(=O)O,,,,val
US20140187545A1,Cc1nn2c(C(N)=O)cc(N3CCOCC3)nc2c1Cc1cccc2ccccc12>>Cc1nn2c(C#N)cc(N3CCOCC3)nc2c1Cc1cccc2ccccc12,,CN(C)C=O,,O,O=S(Cl)Cl,val
US20080090887A1,CC(C)c1ccc(O)c(-c2nnc(S)n2-c2ccc3c(c2)CC2(C3)OCCO2)c1O>>CC(C)c1cc(-c2nnc(S)n2-c2ccc3c(c2)CC(=O)C3)c(O)cc1O,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20020025958A1,COc1cc2c(cc1NC(C)=O)CC(C)OC2c1ccc([N+](=O)[O-])cc1.O=S(=O)(O)O>>COc1cc(C(=O)c2ccc([N+](=O)[O-])cc2)c(CC(C)=O)cc1NC(C)=O,,O=S(=O)(O)O,,CC(C)=O,,val
US20110118314A1,CN(C(=O)OCC1c2ccccc2-c2ccccc21)[C@@H](CC(=O)OC(C)(C)C)C(=O)O.COc1cc(F)c(F)cc1-c1ccc(OCC2CCCN(C(=O)[C@H](CC(=O)OC(C)(C)C)N(C)C(=O)OCC3c4ccccc4-c4ccccc43)C2)cc1.COc1cc(F)c(F)cc1-c1ccc(OCC2CCCNC2)cc1.ClCCl>>COc1cc(F)c(F)cc1-c1ccc(OCC2CCCN(C(=O)[C@H](CC(=O)OC(C)(C)C)N(C)C(=O)OCC3c4ccccc4-c4ccccc43)C2)cc1.COc1cc(F)c(F)cc1-c1ccc(OCC2CCCN(C(=O)[C@H](CC(=O)OC(C)(C)C)N(C)C(C)=O)C2)cc1,,ClCCl,,C1CCNCC1,,val
US20140038999A1,CC(C)(C)OC(=O)NC(CO)CC(F)(F)F.Cc1nccc2c1c(=O)n(C)c1cc(Cl)ccc21>>Cc1nccc2c1c(=O)n(C)c1cc(OCC(CC(F)(F)F)NC(=O)OC(C)(C)C)ccc21,,CCOCC,,,,val
US20110034450A1,CC(C)(C)OC(=O)C(c1ccc(CN2N=C(c3ccccc3)OCC2=O)cc1)C1CCCC1>>O=C(O)C(c1ccc(CN2N=C(c3ccccc3)OCC2=O)cc1)C1CCCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04694013,O=C(c1cccc(Oc2ccccc2)n1)C(F)(F)F>>OC(c1cccc(Oc2ccccc2)n1)C(F)(F)F,,CCO,,[BH4-].[Na+],,val
US05472933,Cn1ccc(S(=O)(=O)NC(C)(C)C)c1Br>>Cn1ccc(S(N)(=O)=O)c1Br,,ClCCl,,O=C(O)C(F)(F)F,,val
US04942245,CCCc1c(OCCCSc2nc3ccc(C(=O)O)cc3[nH]2)ccc(C(C)=O)c1O.O=C(OO)c1cccc(Cl)c1>>CCCc1c(OCCCS(=O)c2nc3ccc(C(=O)O)cc3[nH]2)ccc(C(C)=O)c1O,,CO,ClCCl,,,val
US20040254175A1,CC(=O)O.CCCC(Oc1cccc(-c2noc(C)n2)c1)C(=O)Nc1ccc(N2CCCS2(=O)=O)cc1>>CC(=O)[O-].CCCC(Oc1cccc(C(=N)N)c1)C(=O)Nc1ccc(N2CCCS2(=O)=O)cc1,,CO,,O,,val
US20090247507A1,Nc1ncc(Br)c(Cl)c1[N+](=O)[O-].c1cncc(CN2CCNCC2)c1>>Nc1ncc(Br)c(N2CCN(Cc3cccnc3)CC2)c1[N+](=O)[O-],,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20130331349A1,O=C(O)c1c(C2CC2c2ccccc2)noc1C1CC1>>OCc1c(C2CC2c2ccccc2)noc1C1CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04243660,CC(=O)OC(C)=O.CCCCC/C=C\CCCCCCCCCCO>>CCCCC/C=C\CCCCCCCCCCOC(C)=O,,c1ccncc1,,,,val
US20120238548A1,COc1ccc(C(NC2=N[C@](C)(c3cc(N=C(c4ccccc4)c4ccccc4)ccc3F)C(F)(F)COC2)(c2ccccc2)c2ccc(OC)cc2)cc1>>COc1ccc(C(NC2=N[C@](C)(c3cc(N)ccc3F)C(F)(F)COC2)(c2ccccc2)c2ccc(OC)cc2)cc1,,C1COCCO1,,Cl,,val
US05625080,Cc1cccc(C)c1O.O=C(Cl)C(=O)Oc1ccc2c(c1)C(c1ccccc1)C(=O)O2>>Cc1cccc(C)c1OC(=O)C(=O)Oc1ccc2c(c1)C(c1ccccc1)C(=O)O2,,Cc1ccccc1,,,,val
US20120309966A1,Br.Cc1nccn2c([C@@H]3CC[C@@H](CNC(=O)OCc4ccccc4)CC3)nc(Br)c12>>Br.Cc1nccn2c([C@@H]3CC[C@@H](CN)CC3)nc(Br)c12,,Br,,CC(=O)O,,val
US20080287477A1,CC(C)(C)OC(=O)NCCN.O=Cc1ccc(OC(F)(F)F)cc1>>CC(C)(C)OC(=O)NCCNCc1ccc(OC(F)(F)F)cc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20050197338A1,N#CCBr.NC(=O)Nc1cn(-c2ccc(-c3cccc(O)c3)c(Cl)c2)nc1C(N)=O>>N#CCOc1cccc(-c2ccc(-n3cc(NC(N)=O)c(C(N)=O)n3)cc2Cl)c1,,CC(C)=O,ClCCl,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06329370B1,CC(C)(N)CO.COc1ccc(C(=O)Cl)cc1>>COc1ccc(C2=NC(C)(C)CO2)cc1,,ClCCl,,O=S(Cl)Cl,,val
US05196610,CCOc1ccccc1.O=C(C(F)(F)F)C(F)(F)Cl>>CCOc1ccc(C(O)(C(F)(F)F)C(F)(F)Cl)cc1,,ClC(Cl)Cl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130005707A1,COc1ccc(CNc2cccc(OC3CCCCC3)n2)cc1>>Nc1cccc(OC2CCCCC2)n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20050153978A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc(F)cc1N>>CC(C)(C)OC(=O)Nc1cc(F)ccc1N,,O,,CCOC(C)=O,,val
US20150274664A1,CC(C)(C)OC(=O)N1CCC([C@H]2C[C@@H]2CCNc2ncc(-n3cnnn3)cn2)CC1.Cl>>Cl.c1nc(NCC[C@H]2C[C@@H]2C2CCNCC2)ncc1-n1cnnn1,,ClCCl,,C1COCCO1,,val
US20050101644A1,O=Cc1cc(Br)ccc1O.OC1(c2ccc(Br)cc2)CCNCC1>>Oc1ccc(Br)cc1CN1CCC(O)(c2ccc(Br)cc2)CC1,,CCOC(C)=O,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20090093483A1,CC(C)(C)OC(=O)CN.CCOC(=O)C1=C(O)c2ccc(OC)cc2C2(CCOCC2)C1=O>>COc1ccc2c(c1)C1(CCOCC1)C(=O)C(C(=O)NCC(=O)OC(C)(C)C)=C2O,,C1COCCO1,,CCN(C(C)C)C(C)C,Cl,val
US20090182020A1,CNCCc1ccccc1.O=C(O)C#Cc1cccc(Cl)c1>>CN(CCc1ccccc1)C(=O)C#Cc1cccc(Cl)c1,,ClCCl,,ClCCCl,,val
US20140128368A1,CC(C)(C)OC(=O)N1CCC([C@H]2C[C@H]2CI)CC1.CS(=O)(=O)c1ccc(CO)cc1>>CC(C)(C)OC(=O)N1CCC([C@H]2C[C@H]2COCc2ccc(S(C)(=O)=O)cc2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20150266864A1,Cl.NO.O=C(C(=CO)CCN1CCC(O)(c2ccccc2Cl)CC1)c1ccc(F)cc1>>Cl.OC1(c2ccc(Cl)cc2)CCN(CCc2conc2-c2ccc(F)cc2)CC1,,CCO,,CC(C)=O,,val
US04514568,O=c1cnc(-c2ccc([N+](=O)[O-])cc2)c[nH]1>>Nc1ccc(-c2c[nH]c(=O)cn2)cc1,[Pd],CN(C)C=O,,[H][H],,val
US20040087568A1,CNc1nccc(CNc2ccccc2C(=O)Nc2ccc3c(c2)CN(C(=O)OC(C)(C)C)CC3(C)C)n1>>CNc1nccc(CNc2ccccc2C(=O)Nc2ccc3c(c2)CNCC3(C)C)n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20050020587A1,CCOC(=O)c1cc(F)cnc1Oc1cccc(SC)c1>>CSc1cccc(Oc2ncc(F)cc2C(=O)O)c1,,C1CCOC1,,[Li+].[OH-],,val
US20030232849A1,COC(=O)c1ccc(Br)cc1C.COc1ccc(O)cc1>>COC(=O)c1ccc(Oc2ccc(OC)cc2)cc1C,[Cu],CCOCC,,O=C([O-])[O-].[K+].[K+],,val
US20080004269A1,CCCc1c(I)ncnc1I.Oc1ccnn1-c1cccc(F)n1>>CCCc1c(I)ncnc1Oc1ccnn1-c1cccc(F)n1,,CCOC(C)=O,CS(C)=O,O,[H-].[Na+],val
US04294960,CON=C(C(=O)NC1C(=O)N2C(C(=O)[O-])=CCS[C@H]12)c1csc(N)n1.NCCCC[C@H](N)C(=O)O>>CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CCS[C@H]12)c1csc(N)n1.NCCCC[C@H](N)C(=O)O,,O,,Cl,,val
US20100305096A1,CC(C)(C)OC(=O)N1CC(=O)C1.O[C@H]1CCNC1>>CC(C)(C)OC(=O)N1CC(N2CC[C@H](O)C2)C1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090048239A1,CC1(C)OCC(CBr)(CBr)CO1.COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccccc3O)[nH]c2c1>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC1(COc2ccccc2-3)COC(C)(C)OC1,,CN(C)C=O,,[H-].[Na+],,val
US20140187542A1,CCO.COc1ccc2ncc(=O)n(CCCN[C@@H]3CC(=O)N(c4ccc5c(c4)NC(=O)CO5)C3)c2c1.Cl>>COc1ccc2ncc(=O)n(CCCN[C@@H]3CC(=O)N(c4ccc5c(c4)NC(=O)CO5)C3)c2c1.Cl.O,,CCO,ClCCl,C1COCCO1,,val
US20150166567A1,O=P(Cl)(Cl)Cl.O=c1[nH]cnc2sc3c(c12)CCSC3>>Clc1ncnc2sc3c(c12)CCSC3,,Cc1ccccc1,,,,val
US20140045697A1,CC(=O)O.CC(=O)O[C@H]1CC[C@H]2[C@@H]3CC(=O)[C@H]4CCCC[C@]4(C)[C@H]3CC[C@@]21C.CCOC(=O)/N=N/C(=O)OCC>>CO[C@]12C[C@H](OC(C)=O)CC[C@]1(C)[C@H]1CC[C@@]3(C)[C@@H](CC[C@@H]3OC(C)=O)[C@@H]1CC2=O,,C1CCOC1,C1CCOC1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130172302A1,C1CCNC1.CCOC(=O)C(Br)c1ccccc1>>CCOC(=O)C(c1ccccc1)N1CCCC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080114013A1,O=C1Cc2ccc(Cl)cc2N1.O=Cc1ccccn1>>O=C1Nc2cc(Cl)ccc2/C1=C/c1ccccn1,,CC(C)O,,,,val
US20140066424A1,C=C[Sn](CCCC)(CCCC)CCCC.Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1cccc(Br)c1>>C=Cc1cccc(Cn2nc(-c3nc(-c4ccc(OC(F)(F)F)cc4)no3)nc2C)c1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20090093484A1,Cc1cc(OC/C=C(\c2ccccc2)c2ccc(C#CCN3CCOCC3)cc2)ccc1OCC(=O)O.OC/C=C(\c1ccc(I)cc1)c1ccc(-c2ccccc2)nc1>>COC(=O)COc1ccc(OC/C=C(\c2ccc(I)cc2)c2ccc(-c3ccccc3)nc2)cc1C,,C1CCOC1,Cc1ccccc1,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US03980788,CC(=O)OC1c2ccccc2Oc2ccccc21.CN(C)C1CCNCC1>>CN(C)C1CCN(C2c3ccccc3Oc3ccccc32)CC1,,c1ccccc1,,,,val
US20110112127A1,COc1ncc(F)cc1C(=O)Cl.Cc1cnc2[nH]cc(Cc3ccc(N)nc3F)c2c1>>COc1ncc(F)cc1C(=O)Nc1ccc(Cc2c[nH]c3ncc(C)cc23)c(F)n1,,C1CCOC1,,Cl,c1ccncc1,val
US20110195954A1,N#CCc1nc(OCc2ccccc2)ccc1[N+](=O)[O-]>>N#CCc1nc(OCc2ccccc2)ccc1N,[Ni],CC(=O)O,CCO,[H][H],,val
US20070099912A1,Fc1ccc(CBr)cc1.O=c1[nH]ccc2c3c(ccc12)N=CC3>>O=c1c2ccc3[nH]ccc3c2ccn1Cc1ccc(F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040138288A1,NC(N)=S.O=C(CCl)CCl>>Cl.Nc1nc(CCl)cs1,,CC(C)=O,,,,val
US20050059636A1,CC(C)C[C@@H](B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1)N([Si](C)(C)C)[Si](C)(C)C>>CC(C)CB1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1,,CCOCC,,C1COCCO1,Cl,val
US20040082570A1,CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2[nH]c(=O)[nH]c(=O)c21.CC(C)(C)C(=O)OCCl>>CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2c1c(=O)[nH]c(=O)n2COC(=O)C(C)(C)C,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20150018547A1,COC(=O)Cc1csc2c(C)c(OCc3ccc(C(F)(F)F)nc3C)cc(C)c12>>Cc1nc(C(F)(F)F)ccc1COc1cc(C)c2c(CC(=O)O)csc2c1C,,C1CCOC1,,CO,[Na+].[OH-],val
US20080004316A1,C#Cc1cncc(Cl)c1.Cc1ccc(N)c(Br)n1>>Cc1ccc(N)c(C#Cc2cncc(Cl)c2)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCN(CC)CC,,,,val
US03952114,CNCCNC.O=Cc1ccccc1>>CN1CCN(C)C1c1ccccc1,,c1ccccc1,,,,val
US20050054640A1,CC(C)(C)OC(=O)NNc1c(N)cnc2ccccc12.CCCCC(=O)Cl>>CCCCc1nc2cnc3ccccc3c2n1NC(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20130150362A1,CCOC(=O)C1(CO)CCC(c2cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3nccc3n2)CC1.O=C1CCC(=O)N1I>>CCOC(=O)C1(CO)CCC(c2cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3ncc(I)c3n2)CC1,,CC#N,,,,val
US04263037,COS(=O)(=O)OC.Cc1cc(Br)cc(Br)c1O>>COc1c(C)cc(Br)cc1Br,,[Na+],[OH-],,,val
US20020052410A1,CC(C)(C)OC(=O)N1CCCC1C(=O)C(CCc1ccccc1)CCc1ccccc1.ClCCl.O=C([O-])C(=O)Cl>>COC(=O)C(=O)N1CCCC1C(=O)C(CCc1ccccc1)CCc1ccccc1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20130096118A1,CCOC(=O)C=O.CN(C)c1ccc(C(=O)Nc2cccc(C(CN)c3c[nH]c4cc(N5CCOCC5)ccc34)c2F)cc1>>CCOC(=O)c1ncc(-c2cccc(NC(=O)c3ccc(N(C)C)cc3)c2F)c2c1[nH]c1cc(N3CCOCC3)ccc12,,C1COCCO1,,Cc1ccccc1,Cl,val
US20150252036A1,CC(=O)Oc1ccc(OC(C)C)cc1.O=C1CCC(=O)N1Br>>CC(=O)Oc1ccc(OC(C)C)c(Br)c1,,CC#N,,,,val
US20080045528A1,CC(C)C(=O)O.CNC(=O)c1cc(Oc2ccc3nc(N[C@H]4CCCNC4)sc3c2)ccn1>>CNC(=O)c1cc(Oc2ccc3nc(N[C@H]4CCCN(C(=O)C(C)C)C4)sc3c2)ccn1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100069457A1,O=C(O)Cc1ccc(N2C(=O)c3c(c(OCC(F)F)c4ccccc4c3OCC(F)F)C2=O)c(Cl)c1>>O=C(O)Cc1ccc(N2C(=O)c3c(c(OCC(F)F)c4ccccc4c3OCC(F)F)C2O)c(Cl)c1,,C1CCOC1,CCO,[BH4-].[Na+],,val
US04616013,BrBr.O=C1CCc2cc([N+](=O)[O-])ccc21>>O=C1c2ccc([N+](=O)[O-])cc2CC1Br,,CO,ClC(Cl)Cl,,,val
US20140080808A1,COc1ccc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO[Si](C)(C)C(C)(C)C)C5)CC3)cc2)cn1>>COc1ccc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO)C5)CC3)cc2)cn1,,CO,,Cl,,val
US20160229849A1,CN.COc1cc(OC)c(Cl)c(-c2cc3cnc(S(C)=O)nc3n(CC[N+](C)([O-])C3CN(C(=O)OC(C)(C)C)C3)c2=O)c1Cl>>CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CC[N+](C)([O-])C3CN(C(=O)OC(C)(C)C)C3)c2n1,,ClCCl,,,,val
US20120283256A1,Cc1cc(N)cc(CN2CCOCC2)c1N1CCN(C)CC1.Clc1ccc2c(Cl)ccnc2c1>>Cc1cc(Nc2ccnc3cc(Cl)ccc23)cc(CN2CCOCC2)c1N1CCN(C)CC1,,CC#N,,Cl,,val
US20140024776A1,C=CCOCCOCCOCCOCCO.OCC(CO)(CO)CO.[N-]=[N+]=[N-].[N-]=[N+]=[N-].[N-]=[N+]=[N-]>>C=CCOCCOCCOCCOCCOCC(CN=[N+]=[N-])(CN=[N+]=[N-])CN=[N+]=[N-],O,C1CCOC1,,[H-].[Na+],,val
US20160137649A1,CC(C)(C)OC(=O)N1CC2CNCC2C1.O=Cc1ccc(N2CCOCC2)cc1F>>CC(C)(C)OC(=O)N1CC2CN(Cc3ccc(N4CCOCC4)cc3F)CC2C1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20130252937A1,COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(O)cc5C)ccc(F)c43)ccc21.Cn1ccnc1CCl>>COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(OCc6nccn6C)cc5C)ccc(F)c43)ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06395724B1,Cc1c(CO)cc(-c2ccc(S(C)(=O)=O)cc2)n1-c1ccc(F)cc1.Oc1ccc(OCc2ccccc2)cc1>>Cc1c(COc2ccc(OCc3ccccc3)cc2)cc(-c2ccc(S(C)(=O)=O)cc2)n1-c1ccc(F)cc1,,C1CCOC1,O,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090137580A1,Cn1ccc2ncnc(Oc3ccc(N)cc3)c21.Nc1nnc(C(F)(F)F)s1.O=C(Cl)Oc1ccccc1>>Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4nnc(C(F)(F)F)s4)cc3)c21,,CC(=O)N(C)C,,c1ccncc1,,val
US04207324,CC(=O)O.CN(C)c1ccc(-c2nc(Cl)c(CC#N)n2Cc2ccccc2)cc1>>CN(C)c1ccc(-c2nc(Cl)c(CC(=O)O)n2Cc2ccccc2)cc1,,Cl,,O,,val
US06235742B1,CCCc1nn(C)c2c(=O)[nH]c(Cc3ccc(OC)cc3)nc12>>CCCc1nn(C)c2c(=O)[nH]c(Cc3ccc(O)cc3)nc12,,Br,,O=C([O-])[O-].[Na+].[Na+],,val
US20030166639A1,Cc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3cccnc3)c2)cc1C(F)(F)F>>Cc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3cccnc3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US05399578,BrCc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)OCc1ccccc1>>NC(CCC[C@H](NCc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1)C(=O)OCc1ccccc1)C(=O)OCc1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05739132,CCCCS(=O)(=O)Cl.NC1Cc2ccccc2C1>>CCCCS(=O)(=O)NC1Cc2ccccc2C1,,ClCCl,,CCN(CC)CC,,val
US20060276449A1,CCNC(=O)[C@@H]1CC(F)CN1.COc1ccccc1C1(Cl)C(=O)Nc2ccc(Cl)cc21>>CCNC(=O)[C@@H]1CC(F)CN1C1(c2ccccc2OC)C(=O)Nc2ccc(Cl)cc21,,ClC(Cl)Cl,,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20090176847A1,CCN(CC)C(=O)OC1CC2CC(NCC(=O)N3CCCC3C#N)CC2C1.Cl>>CCN(CC)C(=O)OC1CC2CC(NCC(=O)N3CCCC3C#N)CC2C1.Cl,,CCOCC,,,,val
US20030125563A1,BrC(CCCOCCCC(Br)Cc1ccccc1)Cc1ccccc1.C=CCCCCC1=CC(=O)CC1.CCOC1=CC(=O)CC1>>CC(CCC1=CCCC1=O)OCc1ccccc1,,CCOC(C)=O,,C1CCOC1,,val
US20140272095A1,CCOC(=O)C(N)C1CC1C(=O)OC>>NC(C(=O)O)C1CC1C(=O)O,,O,,Cl,[Na+].[OH-],val
US20090124596A1,CC(C)(C)OC(=O)NCCN.O=C(O)c1cccc(-n2c(=O)n([C@@H]3CC[C@H](NC(=O)c4cn5ccccc5n4)CC3)c(=O)c3cc(F)cnc32)c1>>CC(C)(C)OC(=O)NCCNC(=O)c1cccc(-n2c(=O)n([C@@H]3CC[C@H](NC(=O)c4cn5ccccc5n4)CC3)c(=O)c3cc(F)cnc32)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130143892A1,CC(C)(C)OC(=O)N1CCC(N(C(=O)c2cnc(-c3ccc(S(C)(=O)=O)cc3)nc2)C2CC2)CC1>>CS(=O)(=O)c1ccc(-c2ncc(C(=O)N(C3CCNCC3)C3CC3)cn2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110230458A1,CCCCc1nnc(OCC2CN(C(=O)OC(C)(C)C)CCC2(F)F)cc1-c1ccc(OC2CCCCC2)cc1.Cl.ClCCl>>CCCCc1nnc(OCC2CN(C)CCC2(F)F)cc1-c1ccc(OC2CCCCC2)cc1.Cl.Cl,,C1COCCO1,ClCCl,,,val
US20040238786A1,CCN(CC)CC(=O)[O-]>>CCN(CC)CC(=O)O,,O,,O=S(=O)(O)O,,val
US20090208485A1,CC(C)(C)OC(=O)N1CCN(c2cccc(I)c2)CC1.CN(C)C=O.C[Si](C)(C)C(F)(F)F>>CC(C)(C)OC(=O)N1CCN(c2cncc(C(F)(F)F)c2)CC1,[Cu]I,CCOC(C)=O,,[F-].[K+],,val
US20090215750A1,CC(C)(C)C(=O)c1c[nH]c2ncc(Br)nc12.CC1(C)OB(c2ccc(N3CCOCC3)nc2)OC1(C)C>>CC(C)(C)C(=O)c1c[nH]c2ncc(-c3ccc(N4CCOCC4)nc3)nc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20090018103A1,CC(C)(C)OC(=O)N[C@H](COS(C)(=O)=O)CC1CCC(F)(F)CC1.CN>>CNC[C@H](CC1CCC(F)(F)CC1)NC(=O)OC(C)(C)C,,CCOC(C)=O,,,,val
US05463077,COc1ccccc1[C@]1(O)CCC(c2ccccc2)(c2ccccc2)[C@H]2CNC[C@H]21.O=C(Cl)C(=O)c1c[nH]c2ccccc12>>COc1ccccc1[C@]1(O)CCC(c2ccccc2)(c2ccccc2)[C@H]2CN(C(=O)C(=O)c3c[nH]c4ccccc34)C[C@H]21,,ClCCl,,CCN(CC)CC,Cl,val
US20110237529A1,NN.O=C(C[N+](=O)[O-])c1ccccc1>>NN=C(C[N+](=O)[O-])c1ccccc1,,CCO,,CC(=O)O,O,val
US20100322855A1,CC(C)(C)OC(=O)CNC(Cc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)CN1CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1>>O=C(O)CNC(Cc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)CN1CCN(CC(=O)O)CCN(CC(=O)O)CC1,,C1COCCO1,,CCOCC,Cl,val
US20120122834A1,CC1(C)CC(N)CC(C)(C)N1.CCOC(=O)C(=O)Nc1ccc(Cl)c(F)c1>>CC1(C)CC(NC(=O)C(=O)Nc2ccc(Cl)c(F)c2)CC(C)(C)N1,,CCO,,,,val
US20050054649A1,Cc1ccc(-c2cn(-c3nc(-c4cccc(N)c4)cn4ccnc34)cn2)cc1.Cc1ccccc1N=C=O>>Cc1ccc(-c2cn(-c3nc(-c4cccc(NC(=O)Nc5ccccc5C)c4)cn4ccnc34)cn2)cc1,,ClCCl,,CN(C)C=O,,val
US20050208582A1,Fc1cc2[nH]ncc2cc1Br.O=C1CCC(=O)N1I>>Fc1cc2[nH]nc(I)c2cc1Br,,CCOC(C)=O,CN(C)C=O,,,val
US04916148,CC1(C)C(=O)Oc2ccc3cc(C#N)c(CBr)cc3c21.c1nc[nH]n1>>CC1(C)C(=O)Oc2ccc3cc(C#N)c(Cn4cncn4)cc3c21,,CN(C)C=O,,O,[Na],val
US20090264445A1,COC(=O)[C@H](CC1CCCCC1)N1CC(Oc2cccc(OC)c2)=CC1=O>>COc1cccc(OC2=CC(=O)N([C@@H](CC3CCCCC3)C(=O)O)C2)c1,,C1CCOC1,O,[Li+].[OH-],,val
US04382947,CC(C)n1cc(O)cn1.CN=C=O>>CNC(=O)Oc1cnn(C(C)C)c1,CCN(CC)CC,CC(C)=O,,,,val
US20090221853A1,CN(C)C(=O)CCl.OCCO>>CN(C)C(=O)COCCO,,OCCO,,[Na],,val
US05569669,COc1cccc2c1OCCO2>>Oc1cccc2c1OCCO2,,ClCCl,,BrB(Br)Br,,val
US20030216570A1,CC1(C)COc2c(C(=O)c3ccccc3)cc(Br)cc21>>CC1(C)COc2c(Cc3ccccc3)cc(Br)cc21,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20070111984A1,Cn1ncnc1-c1cc(F)ccc1Br.N#C[Cu]>>Cn1ncnc1-c1cc(F)ccc1C#N,,CN(C)C=O,,,,val
US20110105504A1,C[C@H](N)c1ccc(Br)cc1.O=C(CBr)c1ccccc1>>C[C@H](NCC(=O)c1ccccc1)c1ccc(Br)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20060252811A1,Clc1cc(I)cc(CBr)c1.Fc1ccc(OCc2ncc[nH]2)cc1>>Fc1ccc(OCc2nccn2Cc2cc(Cl)cc(I)c2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060142265A1,CN1CC(=O)Nc2ncc(/C=C/C(=O)OC(C)(C)C)cc2C1>>CN1CC(=O)Nc2ncc(/C=C/C(=O)O)cc2C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120309769A1,CC(C)(N)c1ccccc1.O=C(O)c1ccc2c(ccn2Cc2ccc(F)cc2F)c1>>CC(C)(NC(=O)c1ccc2c(ccn2Cc2ccc(F)cc2F)c1)c1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080312226A1,O=C=Nc1ccccc1Cl.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>O=C(Nc1ccccc1Cl)N1CCN(c2nc(-c3ccccc3)ns2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US05166347,CC(C)OC(=NC#N)c1cccnc1.NCc1ccc([N+](=O)[O-])cc1>>N#CNC(=NCc1ccc([N+](=O)[O-])cc1)c1cccnc1,,CO,,CCN(CC)CC,Cl,val
US20080139484A1,Cc1cccc2c1c(Cc1ccc(/C=C/CC(=O)OC[C@@H]3COC(C)(C)O3)cc1)cn2[C@@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1>>Cc1cccc2c1c(Cc1ccc(/C=C/CC(=O)OC[C@@H](O)CO)cc1)cn2[C@@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1,,CO,ClCCl,,,val
US20050187390A1,CC(=O)c1cc(Cl)c(N)c(Cl)c1.O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4cc(Br)ccc4O)ccc3c1)n2C1CCCCC1>>Nc1c(Cl)cc(-c2ccc3cc(-c4nc5cc(C(=O)O)ccc5n4C4CCCCC4)ccc3n2)cc1Cl,,CCO,,[K+].[OH-],,val
US20070244103A1,CC(C)[Si](Oc1cccc(N)c1N)(C(C)C)C(C)C.CCOC(=O)C=O>>CC(C)[Si](Oc1cccc2ncc(=O)[nH]c12)(C(C)C)C(C)C,,CCO,Cc1ccccc1,,,val
US20090029996A1,CCn1nc(-c2ccccc2)c(C(=O)OC(C)OC(=O)OC2CCCCC2)c(Nc2cccnc2)c1=O.CCn1nc(-c2ccccc2)c(C(=O)OC(C)OC(=O)OC2CCCCC2)c(Nc2cnccc2C)c1=O>>CCn1nc(-c2ccccc2)c(C(=O)OCCOC(=O)OC2CCCCC2)c(Nc2cccnc2)c1=O,,CO,,,,val
US20040127426A1,CCC(NC(=O)C(N)CC1CCCCC1)C(O)c1nc2ccccc2o1.COC(=NS(C)(=O)=O)c1ccccc1>>CCC(NC(=O)C(CC1CCCCC1)NC(=NS(C)(=O)=O)c1ccccc1)C(O)c1nc2ccccc2o1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20110306607A1,O=C(N1C2CCC1CC1(C2)Oc2ccccc2-n2cccc21)C(F)(F)F>>c1ccc2c(c1)OC1(CC3CCC(C1)N3)c1cccn1-2,,CO,,[Na+].[OH-],,val
US04398029,C1CCNC1.CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)c(F)c21>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCCC3)c(F)c21,,c1ccncc1,,,,val
US20060281772A1,COc1cc2ncnc(C3CCN(C(=O)Cl)CC3)c2cc1OC.Nc1ccc(-n2ccnc2)cc1>>COc1cc2ncnc(C3CCN(C(=O)Nc4ccc(-n5ccnc5)cc4)CC3)c2cc1OC,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20100010058A1,CC(C)(C)OC(=O)N(C1=NCCS1)N(Cc1ccc(Cl)c(C(F)(F)F)c1)c1ccccc1>>FC(F)(F)c1cc(CN(NC2=NCCS2)c2ccccc2)ccc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090318475A1,COC(=O)CCCCCNc1ncnc2oc(-c3ccccc3)c(-c3ccccc3)c12>>O=C(O)CCCCCNc1ncnc2oc(-c3ccccc3)c(-c3ccccc3)c12,O,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20070010511A1,CC(C)=CC(=O)Cl.COC(=O)c1ccccc1N>>COC(=O)c1ccccc1NC(=O)C=C(C)C,,Cc1ccccc1,,CCN(CC)CC,,val
US20100311729A1,Nc1ncc(-c2ccc3ncc(-c4ccc(F)nc4)n3n2)cc1C(F)(F)F.O>>Nc1ncc(-c2ccc3ncc(-c4ccc(O)nc4)n3n2)cc1C(F)(F)F,,O,,CC(=O)O,,val
US20020068737A1,O=C(Cl)c1ccc(F)cc1F.O=C1CCNCC1>>O=C1CC(C(=O)c2ccc(F)cc2F)CCN1,,CCN(CC)CC,ClCCl,Cl,O,val
US20030232869A1,CI.COC(=O)c1cc2[nH]cnc2c(F)c1Nc1ccc(Br)cc1Cl>>COC(=O)c1cc2c(ncn2C)c(F)c1Nc1ccc(Br)cc1Cl,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20130210785A1,C/C(=N\O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C.CC(=O)OC(C)=O>>CC(=O)O/N=C(\C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20120329780A1,CN(C)Cc1ccc(N)cc1.COc1ccc(Cn2cc3nc(-c4ccccc4)nc(Cl)c3n2)cc1>>CN(C)Cc1ccc(Nc2nc(-c3ccccc3)nc3cn[nH]c23)cc1,C1COCCO1,CO,,Cl,,val
US20140323501A1,CC(N)=O.CCOC(=O)C(CCc1ccc(Oc2ccc(C(=O)COC(=O)C(C)C)cc2)cc1)(NC(C)=O)C(=O)OCC>>CCOC(=O)C(CCc1ccc(Oc2ccc(-c3coc(C(C)C)n3)cc2)cc1)(NC(C)=O)C(=O)OCC,,Cc1ccccc1C,,CCOCC,FB(F)F,val
US20110105504A1,C=C(C)CC1(c2ccccc2)CN([C@@H](C)c2ccc(Br)cc2)C(=O)O1.O=C(OO)c1cccc(Cl)c1>>C[C@@H](c1ccc(Br)cc1)N1CC(CC2(C)CO2)(c2ccccc2)OC1=O,,ClCCl,,,,val
US04690929,CCOC(=O)CBr.CN1C[C@H](CN)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21>>CCOC(=O)CNC[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1,,CN(C)C=O,,,,val
US20040127574A1,CCc1cc(Oc2ccc(C3OC(=O)NC3Cc3cccc(OC(F)(F)C(F)F)c3)cc2)ccc1Cl>>CCc1cc(Oc2ccc(C(O)C(N)Cc3cccc(OC(F)(F)C(F)F)c3)cc2)ccc1Cl,,CCO,,[Na+].[OH-],,val
US20100075952A1,CCNCCN1CCCc2[nH]c(C=O)c(C)c2C1=O.O=C1Cc2cc(F)ccc2N1>>CCNCCN1CCCc2[nH]c(C=C3C(=O)Nc4ccc(F)cc43)c(C)c2C1=O,,CCO,,C1CCNCC1,,val
US20080293749A1,Nc1ccccc1CNC1CC(=O)NC1=O.O=C(n1ccnc1)n1ccnc1>>O=C1CC(N2Cc3ccccc3NC2=O)C(=O)N1,,C1CCOC1,,,,val
US08999986B2,COCOC(C)(c1cccc(F)c1)c1cc(-c2c[nH]c3ncc(Br)nc23)nc(N)n1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>COCOC(C)(c1cccc(F)c1)c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)nc23)nc(N)n1,,CN(C)C=O,,,,val
US20070073056A1,CC1C(C(=O)O)=NN(c2ccc(Cl)cc2Cl)C1c1ccc(Cl)cc1.CI>>COC(=O)C1=NN(c2ccc(Cl)cc2Cl)C(c2ccc(Cl)cc2)C1C,,CN(C)C=O,,O,,val
US20120041009A1,O=C(Cl)N1CCCC1.O=c1nc(-c2cc(-c3cccc(C(F)(F)F)c3)ncn2)[nH]o1>>O=C(N1CCCC1)n1c(-c2cc(-c3cccc(C(F)(F)F)c3)ncn2)noc1=O,,c1ccncc1,,C1CCC2=NCCCN2CC1,,val
US20130053364A1,BrBr.COC(=O)C1C(=O)C=CCC1C>>COC(=O)c1c(C)ccc(Br)c1O,,CC(=O)O,,,,val
US05557002,CC1(C)COC(c2ccccc2-c2ccc(CO)cc2)=N1.O=S(Cl)Cl>>CC1(C)COC(c2ccccc2-c2ccc(CCl)cc2)=N1,,ClCCl,,O=C([O-])O.[Na+],,val
US20100249119A1,CN(c1ccc(F)c(NC(=O)c2cccc(OC(C)(C)C#N)c2Cl)c1)c1ccc2nc(NC(=O)C3CC3)sc2n1.O=S(=O)(O)O>>CN(c1ccc(F)c(NC(=O)c2cccc(OC(C)(C)C#N)c2Cl)c1)c1ccc2nc(NC(=O)C3CC3)sc2n1.O=S(=O)(O)O,,CCCCCCC,CCOC(C)=O,,,val
US20040220208A1,CCc1nc(C)[nH]c1C.O=C(Cl)c1ccccc1>>CCc1nc(CC(=O)c2ccccc2)[nH]c1C.Cl,,CC#N,,,,val
US20070082890A1,CCOC(=O)CBr.O=C1COCCN1>>CCOC(=O)CN1CCOCC1=O,,CN(C)C=O,,[H-].[Na+],,val
US06060468,Clc1ccc2c(c1)C(Cl)Cc1ccccc1S2.OCCBr>>Clc1ccc2c(c1)C(OCCBr)Cc1ccccc1S2,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20080132510A1,CCCc1c(COC(C)=O)nnc(Cl)c1C1OCCO1.O=S(Cl)Cl>>CCCc1c(CCl)nnc(Cl)c1C1OCCO1,,C1CCOC1,ClCCl,[Li+].[OH-],,val
US20160152616A1,CC1(C)CCn2c(=O)c(=O)[nH]c3cccc1c32.CC=CCBr>>C/C=C/Cn1c(=O)c(=O)n2c3c(cccc31)C(C)(C)CC2,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US06903107B1,C=CC(=O)OCC.CC(C)(C)OC=O.NC1CCC1>>CCOC(=O)CCN(C(=O)OC(C)(C)C)C1CCC1,,CCCCCCC,CCOC(C)=O,,,val
US20040220403A1,CC(=O)Cl.COc1ccccc1CN1CC(C(c2ccccc2)c2ccccc2)N2CCCNC(=O)[C@H]2C1>>COc1ccccc1CN1CC(C(c2ccccc2)c2ccccc2)N2CCCN(C(C)=O)C[C@H]2C1,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20130324404A1,CON1CCC2(CC1)C(O)=C(c1c(C)ccc(Cl)c1C)C(=O)N2OC.O=[N+]([O-])O>>CON1CCC2(CC1)C(=O)C(c1c(C)ccc(Cl)c1C)([N+](=O)[O-])C(=O)N2OC,,ClC(Cl)Cl,,,,val
US20040121989A1,CCCCc1nc(CCCNC(=O)OC(C)(C)C)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)n1>>CCCCc1nc(CCCN)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)n1,,C1COCCO1,Cl,,,val
US05374772,COC(=O)c1cc(OCCCc2ccccc2)cc(OCCCc2ccccc2)c1>>O=C(O)c1cc(OCCCc2ccccc2)cc(OCCCc2ccccc2)c1,,C1COCCO1,CO,[Na+].[OH-],,val
US20100303928A1,CCOC(=O)c1onc(-c2ccc(OC)cc2)c1C.O=C1CCC(=O)N1Br>>CCOC(=O)c1onc(-c2ccc(OC)cc2)c1CBr,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20110003806A1,CCOC(=N)c1sc(Br)c(C#N)c1-c1ccc(Cl)cc1Cl.COC(=O)C(N)CN>>COC(=O)C1CN=C(c2sc(Br)c(C#N)c2-c2ccc(Cl)cc2Cl)N1,,CCO,,Cl,Cl,val
US05478858,Cc1c(N=C=S)ccc2c1ncn2C(=O)OC(C)(C)C.NCCN>>Cc1c(NC(=S)NCCN)ccc2c1ncn2C(=O)OC(C)(C)C,,ClCCl,,CCOCC,,val
US20020103229A1,CC(C)(C)OC(=O)NNC(=O)c1ccc2[nH]nc(-c3ccc(F)cc3)c2c1>>NNC(=O)c1ccc2[nH]nc(-c3ccc(F)cc3)c2c1,,C1COCCO1,,Cl,[Na+].[OH-],val
US20040235865A1,CC(=O)OC(C)=O.CCOC(=O)Cc1c(F)cccc1Cl>>CCOC(=O)CC(=O)Cc1c(F)cccc1Cl,,C1CCOC1,,Cl,[H-].[Na+],val
US20060205794A1,O=S(=O)(c1cccc(C#CCCOCCCCCCBr)c1)C1CCCC1>>O=S(=O)(c1cccc(CCCCOCCCCCCBr)c1)C1CCCC1,[Pd],CCOC(C)=O,,,,val
US20090030016A1,C=O.NC(=O)c1cccc2[nH]c(-c3ccc([C@H]4CCCN4)s3)nc12>>CN1CCC[C@@H]1c1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)s1,,CO,O,[BH3-]C#N.[Na+],,val
US05192773,O=C(OCc1ccccc1)C1CCCCN1>>O=C(OCc1ccccc1)[C@@H]1CCCCN1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20110206607A1,Cc1ccc(S(=O)(=O)OCCOc2cccc3nc(-c4c(F)cc(O[Si](C)(C)C(C)(C)C)cc4F)c(Nc4ccc5c(c4)OCCO5)n23)cc1>>Cc1ccc(S(=O)(=O)OCCOc2cccc3nc(-c4c(F)cc(O)cc4F)c(Nc4ccc5c(c4)OCCO5)n23)cc1,,C1CCOC1,,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20150225397A1,Cc1ncc2c(n1)C1(c3ccccc3)C/C(=C/O)C(=O)C(C)C1CC2.NO>>Cc1ncc2c(n1)C1(c3ccccc3)Cc3cnoc3C(C)C1CC2,,CO,O,Cl,,val
US06410657B1,C1CCCCC1.C1CCOC1.C=CC=C.C=Cc1ccccc1.CBr.[Li]CCCC>>C=CC=C.C=Cc1ccccc1.C=Cc1ccccc1,,C1CCCCC1,C1CCOC1,,,val
US20110172252A1,CCOCCO.Cc1ccc(-c2nc(N)nc3c2nnn3Cc2cccc(CBr)n2)o1>>CCOCCOCc1cccc(Cn2nnc3c(-c4ccc(C)o4)nc(N)nc32)n1,,C1CCOC1,,[H-].[Na+],,val
US05556864,COc1ccccc1CCc1ccccc1OCCC1CCCN1C.Cl>>COc1ccccc1CCc1ccccc1OCCC1CCCN1C.Cl,,C1COCCO1,,CCOC(C)=O,,val
US05183820,Cc1ncoc1CCl.Cn1c2c(c3cccc(F)c31)C(=O)NCC2>>Cc1ncoc1CN1CCc2c(c3cccc(F)c3n2C)C1=O,,COCCOC,,O,[H-].[Na+],val
US06166050,CCOc1c(N[C@@H](Cc2ccccc2)C(=O)OC)c(=O)c1=O.NCc1ccccc1>>COC(=O)[C@H](Cc1ccccc1)Nc1c(NCc2ccccc2)c(=O)c1=O,,CCO,,,,val
US20120177748A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ncc(Br)cc1-c1nnc(-c2ccccc2)o1.O=C(O)c1ccc(B(O)O)cc1>>Nc1ncc(-c2ccc(C(=O)O)cc2)cc1-c1nnc(-c2ccccc2)o1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,,O,O=C([O-])[O-].[Na+].[Na+],val
US04472316,CC(O)=S.COC(=O)C=CC(=O)c1ccc(Oc2ccccc2)cc1>>COC(=O)C(CC(=O)c1ccc(Oc2ccccc2)cc1)SC(C)=O,,CCOCC,,,,val
US04107310,CCOC(=O)c1c(-c2ccccc2)nc2c(C(F)(F)F)cccc2c1O>>O=C(O)c1c(-c2ccccc2)nc2c(C(F)(F)F)cccc2c1O,,CCO,,,,val
US20070281916A1,C=CCN1OC=CC1NC(=O)OC(C)(C)C.CS(=O)(=O)OCC1CC(c2ccc(I)c(F)c2)=NO1>>CC(C)(C)OC(=O)N(CC1CC(c2ccc(I)c(F)c2)=NO1)c1ccon1,,CN(C)C=O,,[H-].[Na+],,val
US20100292233A1,CC(C)(C)OC(=O)CC1CCn2c1cc1cc(C(N)=NO)ccc12.N#Cc1cc(OC(F)(F)F)cc(C(=O)Cl)c1>>CC(C)(C)OC(=O)CC1CCn2c1cc1cc(-c3noc(-c4cc(C#N)cc(OC(F)(F)F)c4)n3)ccc12,,C1COCCO1,,CCN(CC)CC,,val
US20100120761A1,CN=C=S.NNC(=O)c1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1>>Cn1c(S)nnc1-c1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1,,CCO,,,,val
US20070213341A1,C=C(C)C1N(CC(=O)F)C(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12.CC(C)(N)CO>>C=C(C)C1N(CC(=O)NC2CC2)C(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12,CN(C)c1ccncc1,C1CCOC1,,CN1CCOCC1,,val
US20080221101A1,C[C@@H](N)c1cccc(Cl)c1.O=Cc1ccc(Cl)c([N+](=O)[O-])c1>>C[C@@H](NCc1ccc(Cl)c([N+](=O)[O-])c1)c1cccc(Cl)c1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20020193367A1,CCCN(C)c1cc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])cc1C(F)(F)F>>CCCN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F,[Pd],,,,,val
US20120088755A1,Cc1nc2cc(Oc3cc(Cl)ncn3)cc(Cl)c2[nH]1.O=C1Nc2ncccc2C2(CCNCC2)O1>>Cc1nc2cc(Oc3cc(N4CCC5(CC4)OC(=O)Nc4ncccc45)ncn3)cc(Cl)c2[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20160031934A1,COC(=O)[C@@]1(C)CCCN1C(=O)OC(C)(C)C.O>>COC(=O)[C@@]1(C)CCC(=O)N1C(=O)OC(C)(C)C,,CCO,,,,val
US20030158246A1,CCOC(=O)CC1CCCCC1=O.NNc1ccc(F)cc1Br>>CCOC(=O)CC1CCCc2c1[nH]c1c(Br)cc(F)cc21,,CC(=O)O,,CCO,Cl,val
US04542145,NCCCn1cncn1.O=C(Cl)c1ccco1>>O=C(NCCCn1cncn1)c1ccco1,,ClCCl,,[Na+].[OH-],,val
US20090239866A1,CC1(C)CCNC1=O.O=C(Cl)OCc1ccccc1>>CC1(C)CCN(C(=O)OCc2ccccc2)C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20130072677A1,CNC(=O)C(C(=O)OC)N(C)C(=O)c1ccc(/C=C/C#Cc2ccc(C=O)cc2)cc1.NC1CC1>>CNC(=O)C(C(=O)OC)N(C)C(=O)c1ccc(/C=C/C#Cc2ccc(CNC3CC3)cc2)cc1,,ClC(Cl)Cl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20160263252A1,COC(=O)COc1ccc(F)cc1OCC(=O)OC>>O=C(O)COc1ccc(F)cc1OCC(=O)O,,O,,[H][H],,val
US20120165318A1,COC(=O)c1ccc2nc(N3CCCCC3)c(-c3ccccc3)nc2c1>>O=C(O)c1ccc2nc(N3CCCCC3)c(-c3ccccc3)nc2c1,,CO,,Cl,[Na+].[OH-],val
US06962923B2,CCOc1ccccc1Br.Cc1ccc(-c2c(O)nn(C)c2N)cc1>>Cc1ccc(-c2c(OCCOc3ccccc3)nn(C)c2N)cc1,,CN(C)C=O,O,[H-].[Na+],,val
US20050158863A1,CCCCN.Cc1n[nH]c(=S)[nH]c1=O>>Cc1nn(CCCCN)c(=S)[nH]c1=O,,CCO,,,,val
US20050282812A1,CCC1CN(C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2cc(C(F)(F)F)ccc2N1C[C@@H]1CC[C@@H](CC(=O)OC(C)(C)C)CC1.Cl>>CCC1CN(C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2cc(C(F)(F)F)ccc2N1C[C@@H]1CC[C@@H](CC(=O)O)CC1.Cl,,C1CCOC1,C1COCCO1,,,val
US20050234236A1,CCC1=CC(=CC(=O)OC(C)(C)C)OC1=O.NN>>Cc1cc(CC(=O)OC(C)(C)C)n[nH]c1=O,,CN1CCCC1=O,O,NN,,val
US04547371,CC(C)(C)OC(=O)C(NC=S)C(O)(CBr)C(F)(F)F>>CC(C)(C)OC(=O)[C@H]1N=CSC[C@]1(O)C(F)(F)F,,CC(C)=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20050176767A1,CCCC[Sn](CCCC)(CCCC)c1ccco1.COC(=O)c1nc(Br)cc(OC)c1OCc1ccccc1>>COC(=O)c1nc(-c2ccco2)cc(OC)c1OCc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,,,val
US20120108565A1,CCCC(=O)C(Cl)C(=O)OCC.NC(N)=S>>CCCc1nc(N)sc1C(=O)OCC,,CC#N,,,,val
US20120101123A1,CN(C)/C=C/c1c(Br)cncc1[N+](=O)[O-]>>Brc1cncc2[nH]ccc12,[Zn],CC(=O)O,CCOC(C)=O,,,val
US05082954,CCCCCCCCCCCCC(N)c1coc([Si](C)(C)C)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCCCCCCCCCCCC(NC(=O)C(F)(F)F)c1coc([Si](C)(C)C)c1,,ClCCl,,CCN(CC)CC,,val
US20080280910A1,NN.O=C1OC(=Cc2csc(-c3ccccc3)n2)c2ccccc21>>O=c1[nH]nc(Cc2csc(-c3ccccc3)n2)c2ccccc12,,O,,,,val
US05495020,CC(=O)Nc1c(F)c(C)c(F)c(F)c1[N+](=O)[O-]>>Cc1c(F)c(N)c([N+](=O)[O-])c(F)c1F,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20140045821A1,CI.O=C1NCCCSc2c1sc1ccc(O)cc21>>COc1ccc2sc3c(c2c1)SCCCNC3=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100197651A1,O=C(Nc1ccccc1)c1nn(-c2cccc(C(F)(F)F)c2)ccc1=O.c1ccc2[nH]nnc2c1>>O=c1ccn(-c2cccc(C(F)(F)F)c2)nc1C(=Nc1ccccc1)n1nnc2ccccc21,,ClCCl,,O=S(Cl)Cl,,val
US05387600,COc1ccc(N)c(N)c1.S=C=S>>COc1ccc2nc(S)[nH]c2c1,,O,,CCO,[Na+].[OH-],val
US20090005420A1,C=CCBr.Oc1ccc(S)cc1>>C=CCSc1ccc(O)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120252807A1,NCCc1ccncc1.O=C(O)C1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(Cl)cc2)CC1>>O=C(NCCc1ccncc1)C1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(Cl)cc2)CC1,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US04342781,CCCCCCCCCCNC(=O)C=C(c1ccccc1)c1cccc([N+](=O)[O-])c1>>CCCCCCCCCCNC(=O)C=C(c1ccccc1)c1cccc(N)c1,[Fe],CC(=O)O,,,,val
US20030224006A1,NC(=O)N1c2ccccc2C=Cc2ccccc21.O=Cc1ccc(C=O)cc1>>NC(=O)N1c2ccccc2C=Cc2ccccc21.O=Cc1ccc(C=O)cc1,,CO,,,,val
US20090062290A1,Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc(F)cn1>>Cc1ccc(S(=O)(=O)Nc2ccc(F)cn2)cc1,,c1ccncc1,,,,val
US20040127465A1,CCOP(N)(=O)Cc1cc(Cl)ccc1OCC(=O)N1CC(C)N(Cc2ccc(F)cc2)CC1C>>C[C@H]1CN(C(=O)COc2ccc(Cl)cc2CP(N)(=O)O)[C@H](C)CN1Cc1ccc(F)cc1,,ClCCl,,C[Si](C)(C)Br,,val
US04122183,CCCCNC(=O)CNC(C)=O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCCCN(C(=O)C(F)(F)F)c1cnc(C)o1,,ClC(Cl)Cl,,O=C([O-])[O-].[Na+].[Na+],,val
US20030032804A1,N#CCC(=O)O.O=C(NCC1CCCCC1)NCC1CCCCC1>>Nc1cc(=O)n(CC2CCCCC2)c(=O)n1CC1CCCCC1,,CC(=O)OC(C)=O,,,,val
US05059609,CC1CC(=O)CC(=O)C1.N>>CC1CC(=O)C=C(N)C1,,c1ccccc1,,,,val
US20150152047A1,CCOC(=O)c1ccc(CN2CCC[C@H](NC(=O)OC(C)(C)C)C2)c(C(F)(F)F)c1.CI>>CN(C(=O)OC(C)(C)C)[C@H]1CCCN(Cc2ccc(C(=O)O)cc2C(F)(F)F)C1,,C1CCOC1,,O,[H-].[Na+],val
US20060106025A1,CC(=O)OC(C)=O.Nc1cccc2sc3ccccc3c12.O=S(=O)(O)C(F)(F)F>>CC(=O)Nc1cccc2sc3ccccc3c12.O=S(=O)(O)C(F)(F)F,,O,c1ccncc1,,,val
US20050182109A1,Brc1c[nH]cn1.CC(C)Br>>CC(C)n1cnc(Br)c1,,CN(C)C=O,,[H-].[Na+],,val
US04112236,CCCCCC(CCCN(Cc1cccc(C=CC(=O)OCC)c1)S(C)(=O)=O)OC(C)=O>>CCCCCC(O)CCCN(Cc1cccc(C=CC(=O)O)c1)S(C)(=O)=O,,O,,CCO,[Na+].[OH-],val
US20080207654A1,CCCCC(=O)C(Cc1ccc(-c2ccccc2C#N)cc1)C(=O)OC.COCC(=N)N>>CCCCc1nc(COC)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1,,C1COCCO1,CO,Cl,C[O-].[Na+],val
US20040157886A1,O=C(O)C(=O)Nc1cccc([N+](=O)[O-])c1.c1ccc(CC2CCNCC2)cc1>>O=C(Nc1cccc([N+](=O)[O-])c1)C(=O)N1CCC(Cc2ccccc2)CC1,,CCOCC,,,,val
US20050240001A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C(N)(CF)CF>>CC(C)(C)OC(=O)NC(CF)(CF)C(=O)O,,CC#N,,Cl,,val
US20110275651A1,Nc1ccc(-c2nn([C@@H]3CCOC3)c3ncnc(N)c23)cc1.O=C=Nc1cccc(C(F)(F)F)c1>>Nc1ncnc2c1c(-c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)nn2[C@@H]1CCOC1,,ClCCl,,,,val
US20090253656A1,COc1ccc(/C(C#N)=C/c2ccncc2)cc1OC.O=C(OO)c1cccc(Cl)c1>>COc1ccc(/C(C#[N+][O-])=C/c2ccncc2)cc1OC,,ClCCl,,,,val
US05292770,CN(C)C=O.COc1ccc(CCN)cc1Cl.O=C1c2ccccc2C(=O)N1CCCCBr>>COC1(CCN(C)CCCCN)C=CC=C(Cl)C1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20130310358A1,CCNCC.COc1cccc(C(=O)O)c1>>CCN(CC)C(=O)c1cccc(OC)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120316147A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(N)CC(=O)O>>CC(C)(CC(=O)O)NC(=O)OC(C)(C)C,,C1COCCO1,,[Na+].[OH-],,val
US20050020574A1,Nc1ccnc(O)c1[N+](=O)[O-]>>Nc1ccnc(O)c1N,[Pd],CN(C)C=O,,,,val
US20030225276A1,Cc1ccc(S(=O)(=O)Oc2c(-c3ccc(S(C)(=O)=O)cc3)cnn(-c3cccc(Cl)c3)c2=O)cc1.Cl[Mg]C1CCCC1>>CS(=O)(=O)c1ccc(-c2cnn(-c3cccc(Cl)c3)c(=O)c2C2CCCC2)cc1,,C1CCOC1,,O,,val
US20040087581A1,CC1NC(=O)OC1c1ccc(C(C)(C)C)cc1>>C[C@H](N)Cc1ccc(C(C)(C)C)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US20160218303A1,COS(=O)(=O)C(F)(F)F.N#Cc1cc2ncn(-c3ccccc3)c2cc1C#N>>C[n+]1cn(-c2ccccc2)c2cc(C#N)c(C#N)cc21.O=S(=O)([O-])C(F)(F)F,,CCOCC,,ClCCl,,val
US05041673,N[C@@H]1Cc2ccccc2[C@@H](Cl)[C@H]1O.O=C(Cl)c1ccccc1>>O=C(N[C@@H]1Cc2ccccc2[C@@H](Cl)[C@H]1O)c1ccccc1,,Cc1ccccc1,O,O=C([O-])O.[Na+],,val
US20020035134A1,O=[N+]([O-])c1ccc(Cl)nc1.OCc1ccccn1>>O=[N+]([O-])c1ccc(OCc2ccccn2)nc1,,CN(C)C=O,,O,[H-].[Na+],val
US20100041647A1,BrC(Br)(Br)Br.CC(C)(C)OC(=O)N[C@H](C=O)Cc1cccc(F)c1>>CC(C)(C)OC(=O)N[C@H](C=C(Br)Br)Cc1cccc(F)c1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100160303A1,Cc1c(N)cccc1-c1ccc(C(N)=O)c2[nH]c3cc(N4CCCC4=O)ccc3c12.Cc1ccc2ncnc(Cl)c2c1>>Cc1ccc2ncnc(Nc3cccc(-c4ccc(C(N)=O)c5[nH]c6cc(N7CCCC7=O)ccc6c45)c3C)c2c1,,CC(C)O,,Cl,,val
US20050049261A1,BrBr.CC1(C)CNc2nc(-c3ccncc3)cc(=O)n2C1>>Br.CC1(C)CNc2nc(-c3ccncc3)c(Br)c(=O)n2C1,,CC(=O)O,,,,val
US05854234,COC1=NCCC(C)CC1.[Cl-].[NH4+]>>CC1CCNC(=N)CC1.Cl,,CCO,,,,val
US20140274688A1,CC(C)(C)OC(=O)NCCc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1>>NCCc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120232061A1,Cc1ccnc(CCl)c1.Oc1cccnc1Br>>Cc1ccnc(COc2cccnc2Br)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20150158857A1,CC(C)(C)OC(=O)N[C@@H](c1ccccc1)c1cccc(O)c1.COC(=O)c1coc(CCl)n1>>COC(=O)c1coc(COc2cccc([C@@H](NC(=O)OC(C)(C)C)c3ccccc3)c2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05112853,C=CC(C)=CO[Si](C)(C)C.C[Si](C)(C)c1cc(C=O)co1>>CC(C=O)=CCC(O)c1coc([Si](C)(C)C)c1,,ClCCl,,CCOCC,FB(F)F,val
US04888283,COCOc1cccc(OCOC)c1CN.Cl>>COCOc1cccc(OCOC)c1CN.Cl,,CCOCC,,,,val
US20020040048A1,COC(=O)[C@@H]1C[C@@H](SCc2ccc(OC)cc2)CN1S(=O)(=O)c1ccc2ccccc2c1.NN>>COc1ccc(CS[C@@H]2C[C@@H](C(=O)NN)N(S(=O)(=O)c3ccc4ccccc4c3)C2)cc1,,CO,,O,,val
US20070031514A1,Cc1cc(C(F)(C(F)(F)F)C(F)(F)F)ccc1N.O=C1OC(O)c2c(Cl)cccc21>>Cc1cc(C(F)(C(F)(F)F)C(F)(F)F)ccc1NC1OC(=O)c2cccc(Cl)c21,,CO,,,,val
US04363816,Cc1cn(C)c2c1Nc1ccccc1NC2=O.O=C(Cl)CCBr>>Cc1cn(C)c2c1N(C(=O)CCBr)c1ccccc1NC2=O,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20140128383A1,CCOC(=O)C(OC(C)(C)C)c1c(C)sc(C)c1-c1ccc2c(c1)CCCO2>>Cc1sc(C)c(C(OC(C)(C)C)C(=O)O)c1-c1ccc2c(c1)CCCO2,,CO,O,[K+].[OH-],,val
US04001207,CC(=O)C(C)(C)C.CC(C)(C)NN>>CC(=NNC(C)(C)C)C(C)(C)C,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060074111A1,CCOC(=O)COc1ccc(S(=O)(=O)Cl)cc1C.FC(F)(F)c1ccc(-c2cccc(NCCC3CC3)c2)cc1>>CCOC(=O)COc1ccc(S(=O)(=O)N(CCC2CC2)c2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1C,,ClCCl,O,CCN(CC)CC,,val
US05187175,CON(C)C(=O)c1nc(C(C)(C)C)c(O)c(C(C)(C)C)n1.c1cscn1>>CC(C)(C)c1nc(C(=O)c2nccs2)nc(C(C)(C)C)c1O,,C1CCCCC1,C1CCOC1,CC(C)NC(C)C,[Li]CCCC,val
US20070232627A1,Cc1cc(Br)cc(C)c1NC(=O)c1ccc(Sc2ccc(NC(=O)OCC(Cl)(Cl)Cl)cc2)c([N+](=O)[O-])c1>>Cc1cc(Br)cc(C)c1NC(=O)c1ccc(Sc2ccc(NC(=O)OCC(Cl)(Cl)Cl)cc2)c(N)c1,[Fe],,,[Cl-].[NH4+],,val
US20110288299A1,CCOC(=O)c1ccc(Nc2cc3c4c(c2)CCCC4(C)CCC3)cc1>>CC12CCCc3cc(Nc4ccc(C(=O)O)cc4)cc(c31)CCC2,,CCO,,Cl,[Na+].[OH-],val
US20140135291A1,NNC(=O)c1ccc(CO)cc1.S=C=S>>OCc1ccc(-c2nnc(S)o2)cc1,,CCO,CCOC(C)=O,CCN(CC)CC,,val
US05168103,CCOP(=O)(CCNCC(O)CNC(=O)OC(C)(C)C)OCC.CCOc1c(OCC)c(=O)c1=O>>CCOc1c(N(CCP(=O)(OCC)OCC)CC(O)CNC(=O)OC(C)(C)C)c(=O)c1=O,,CCO,,,,val
US04578395,CC(=O)CC(=O)OCC(C)(C)CN(C)Cc1ccccc1.N>>C/C(N)=C/C(=O)OCC(C)(C)CN(C)Cc1ccccc1,,CCO,,,,val
US04399134,C1COCCN1.CC1CCc2c(Cl)c(F)cc3c(=O)c(C(=O)O)cn1c23>>CC1CCc2c(Cl)c(N3CCOCC3)cc3c(=O)c(C(=O)O)cn1c23,,CN(C)P(=O)(N(C)C)N(C)C,,,,val
US20100204226A1,CC(C)(C)c1ccc(Sc2ccc([N+](=O)[O-])cc2Cl)cc1>>CC(C)(C)c1ccc(Sc2ccc(N)cc2Cl)cc1,[Zn],CC(C)=O,CCOC(C)=O,[Cl-].[NH4+],,val
US06881733B1,C=O.CC(=O)C(C)C.CCN(CC)CC.NCc1ccccc1>>CC1(C)CN(Cc2ccccc2)CCC1=O,,CCO,,Cl,[K+].[OH-],val
US20060211697A1,Cc1ccc(Oc2ccc(C=O)cc2C#N)c(O)c1.N[C@@H](CS)C(=O)O>>Cc1ccc(Oc2ccc(C3NC(C(=O)O)CS3)cc2C#N)c(O)c1,,CCO,O,,,val
US06054470,CO[C@@H]1CC[C@H](Cn2ccc(C)c([N+](=O)[O-])c2=O)CC1>>CO[C@@H]1CC[C@H](Cn2ccc(C)c(N)c2=O)CC1,[Pd],CCO,,,,val
US04379921,BrBr.CC(C)(C)C(=O)CC(c1ccc(Cl)cc1Cl)S(=O)(=O)c1ccccc1>>CC(C)(C)C(=O)C(Br)C(c1ccc(Cl)cc1Cl)S(=O)(=O)c1ccccc1,,ClC(Cl)Cl,,,,val
US20120208800A1,CC(=O)N1c2ccc(Br)cc2C(NC=O)CC1C.COC(=O)c1ccc(B(O)O)cc1>>COC(=O)c1ccc(-c2ccc3c(c2)C(NC=O)CC(C)N3C(C)=O)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20120059028A1,CC1(O)CSC(C)(O)CS1.Cc1ccc(C(=O)CC#N)cc1>>Cc1ccc(C(=O)c2c(C)csc2N)cc1,,CCO,,CCN(CC)CC,,val
US20080242694A1,C=Cc1cncc2ccc(-c3nnc(N[C@H](Cc4ccccc4)CN4C(=O)c5ccccc5C4=O)s3)nc12>>CCc1cncc2ccc(-c3nnc(N[C@@H](CN)Cc4ccccc4)s3)nc12,,CCO,,NN,,val
US04143137,CCCCC(C#N)(CCCCCBr)c1ccc(Cl)cc1Cl.c1c[nH]cn1>>CCCCC(C#N)(CCCCCn1ccnc1)c1ccc(Cl)cc1Cl,,O,,CN(C)C=O,,val
US20080306068A1,CC(C)(C)OC(=O)Nc1cccc(OC2CCN(C(=O)OCc3ccccc3)CC2)c1>>Nc1cccc(OC2CCN(C(=O)OCc3ccccc3)CC2)c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US04256481,NCCO.O=C(Cl)C(Cl)Cl.O=C1CCCCC1>>O=C(C(Cl)Cl)N1CCOC12CCCCC2,,O,,c1ccccc1,,val
US20140371278A1,C=CCC1(S(=O)(=O)Cl)CC1.O=c1[nH]c2cc3snnc3c(F)c2n1-c1ccc(I)cc1F>>C=CCC1(S(=O)(=O)n2c(=O)n(-c3ccc(I)cc3F)c3c(F)c4nnsc4cc32)CC1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20060025474A1,CCC(CC)(c1ccc(C#CCCCCC(=O)OC)c(C)c1)c1ccc(/C=C/C(O)(C(F)(F)F)C(F)(F)F)c(C)c1>>CCC(CC)(c1ccc(C#CCCCCC(=O)O)c(C)c1)c1ccc(/C=C/C(O)(C(F)(F)F)C(F)(F)F)c(C)c1,,CO,,CCOC(C)=O,[Na+].[OH-],val
US20070021394A1,CCOC(=O)[C@]1(N)[C@H](OCc2ccc(Cl)c(Cl)c2)C[C@@H]2[C@H]1[C@@]2(F)C(=O)OCC>>N[C@@]1(C(=O)O)[C@H](OCc2ccc(Cl)c(Cl)c2)C[C@@H]2[C@H]1[C@@]2(F)C(=O)O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20100298290A1,CI.CS(=O)(=O)Nc1cc(Br)cnc1Cl>>CN(c1cc(Br)cnc1Cl)S(C)(=O)=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150005279A1,C=CC(=O)Cl.C[C@H](c1ccc(C(N)=O)c2[nH]ccc12)C1CNC1>>C=CC(=O)N1CC([C@H](C)c2ccc(C(N)=O)c3[nH]ccc23)C1,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20140350011A1,CC12CCC(Nc3c(Cl)cnc(N)c3N)(CC1=O)C2(C)C.O=Cc1ccc(N2CCOCC2)cc1>>CC12CCC(Nc3c(Cl)cnc4[nH]c(-c5ccc(N6CCOCC6)cc5)nc34)(CC1=O)C2(C)C,,CCO,,C,O=C[O-].[NH4+],val
US20090156612A1,N[C@@H]1CCCCC[C@H]1O.[C-]#[N+]C(C(=O)OCC)=C(Br)c1ccccc1>>CCOC(=O)c1ncn([C@@H]2CCCCC[C@H]2O)c1-c1ccccc1,,CN(C)C=O,,CCN(CC)CC,,val
US20050277652A1,Clc1ccnc(Cl)n1.O=[N+]([O-])c1ccc(O)cc1F>>O=[N+]([O-])c1ccc(Oc2cc(Cl)ncn2)cc1F,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20120244149A1,CCOC(=O)C(C)(C)n1cc(-c2ccc3c(c2)OCCn2cc(-c4ncnn4C(C)C)nc2-3)cn1>>CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(-c3cnn(C(C)(C)C(=O)O)c3)cc1OCC2,,O,,[Li+].[OH-],,val
US20030109459A1,COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1(Cc2ccc(OC)cc2)CCCC1>>COC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)C1(Cc2ccc(OC)cc2)CCCC1,,CCO,,,,val
US20140275027A1,CN(C)C(=O)CCl.COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCNCC3)c(C#N)c12>>COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(=O)N(C)C)CC3)c(C#N)c12,,CN(C)C=O,,CCN(CC)CC,,val
US20120010241A1,O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1cccc2[nH]ncc12>>O=S(=O)(Oc1cccc2[nH]ncc12)C(F)(F)F,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20130296377A1,Cc1ccc(S(=O)(=O)n2ccc3c(COC4CCCCO4)c(Cl)cc(C)c32)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c(CO)c(Cl)cc(C)c32)cc1,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120244073A1,Nc1ccccc1Oc1ccccc1.O=Cc1cccc2c1OCC2>>c1ccc(Oc2ccccc2NCc2cccc3c2OCC3)cc1,,Cc1ccccc1,,Cl,[BH4-].[Na+],val
US06218394B1,CC(=O)Cl.Nc1ccc2c(c1)C(CN1CCC(c3ccc(F)cc3)CC1)CC2>>CC(=O)Nc1ccc2c(c1)C(CN1CCC(c3ccc(F)cc3)CC1)CC2,,ClCCl,,CCN(CC)CC,O,val
US03951981,CSC1=Nc2cc(SC)ccc2Nc2cscc21.OCCN1CCNCC1>>CSc1ccc2c(c1)N=C(N1CCN(CCO)CC1)c1cscc1N2,,CC(=O)O,,O,,val
US20070254868A1,ClP(Cl)(Cl)(Cl)Cl.O=C(Nc1cccc(Cl)c1Cl)c1cc(Br)cnc1Cl>>ClC(=Nc1cccc(Cl)c1Cl)c1cc(Br)cnc1Cl,,c1ccccc1,,,,val
US04568700,C=O.CC1CC[C@H](C(C)C)[C@@H](O)C1.ClCC(Cl)Cl>>CC1CCC(C(C)C)C(OCCl)C1,,Cl,,,,val
US20020049226A1,Cc1cc([N+](=O)[O-])cc(Cl)c1Oc1ccc(O)c(COc2ccc(F)cc2)c1>>Cc1cc(N)cc(Cl)c1Oc1ccc(O)c(COc2ccc(F)cc2)c1,[Zn],CC(=O)O,CCOC(C)=O,,,val
US04865618,COc1c(Cl)cc(NC(C)=O)c(OC)c1[N+](=O)[O-]>>COc1c(Cl)cc(NC(C)=O)c(OC)c1N,[Fe],CC(=O)O,,O,[H][H],val
US20120219522A1,O=[N+]([O-])c1ccc(Oc2ccnc3cc(OCc4ccccc4)ccc23)c(F)c1>>Nc1ccc(Oc2ccnc3cc(O)ccc23)c(F)c1,[Pd],CCO,O,O=C[O-].[NH4+],,val
US06562823B1,Cc1nc(CN2CCN(c3cccc4ccc(OCc5ccccc5)cc34)C(=O)C2)cn1Cc1ccc(C#N)c(F)c1>>Cc1nc(CN2CCN(c3cccc4ccc(O)cc34)C(=O)C2)cn1Cc1ccc(C#N)c(F)c1,[Pd],CCOC(C)=O,CO,[H][H],,val
US20150270492A1,Brc1cccc(Br)c1I.OB(O)c1ccccc1>>Brc1cccc(Br)c1-c1ccccc1,,CO,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20120214769A1,CC(C)(C)OC(=O)c1ccc(NC(C(=O)Nc2ccc(I)cc2)c2ccc(C(C)(C)C)cc2)cc1>>CC(C)(C)c1ccc(C(Nc2ccc(C(=O)O)cc2)C(=O)Nc2ccc(I)cc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090062268A1,C=O.NC(=O)c1cccc2[nH]c([C@@]34CC[C@@H](CN3)C4)nc12>>CN1C[C@@H]2CC[C@@]1(c1nc3c(C(N)=O)cccc3[nH]1)C2,,CO,,[BH3-]C#N.[Na+],,val
US04771046,CC(C(=S)c1ccccc1)[C@H]1NC(=O)[C@@H]1[C@@H](C)O[Si](C)(C)C.O=C(Cl)C(=O)OCc1ccc([N+](=O)[O-])cc1>>CC(C(=S)c1ccccc1)[C@@H]1[C@@H]([C@@H](C)O[Si](C)(C)C)C(=O)N1C(=O)C(=O)OCc1ccc([N+](=O)[O-])cc1,,ClCCl,,CCN(CC)CC,,val
US20110059943A1,COc1ccc(CN(C(=O)OC(C)(C)C)c2nc(N=C(c3ccccc3)c3ccccc3)cc3c2ncn3C)c(OC)c1>>COc1ccc(CN(C(=O)OC(C)(C)C)c2nc(N)cc3c2ncn3C)c(OC)c1,,C1CCOC1,,Cl,,val
US05486466,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@@H](N)CS>>COC(=O)[C@H](CS)NC(=O)OC(C)(C)C,,C1COCCO1,,CN1CCOCC1,Cl,val
US05399574,CN1CCC(=O)CC1.O=C1N[C@@H](Cc2ccc3[nH]ccc3c2)CO1>>CN1CC=C(c2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)CC1,,CC(=O)O,,,,val
US20070037881A1,CC(=O)CCl.N#Cc1ccc(Oc2ccc(Cl)cc2Cl)c(O)c1>>CC(=O)COc1cc(C#N)ccc1Oc1ccc(Cl)cc1Cl,,CC(C)=O,,[I-].[K+],,val
US20080319005A1,CCOC(=O)Cc1ccc(-n2cnc3cccnc32)cc1Cl>>O=C(O)Cc1ccc(-n2cnc3cccnc32)cc1Cl,,C1CCOC1,,Cl,[Li+].[OH-],val
US20150018335A1,CN(C)C(=O)c1cc(-c2ccccc2)ccc1CN1CCN(C(=O)OC(C)(C)C)CC1>>CN(C)C(=O)c1cc(-c2ccccc2)ccc1CN1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05650428,CCC[C@H](NS(=O)(=O)c1ccc(Br)cc1)C(O)=S.COC(=O)C(C)c1ccc(N)cc1>>CCC[C@H](NS(=O)(=O)c1ccc(Br)cc1)C(=S)Nc1ccc(CCC(=O)OC)cc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20090149425A1,CC(C)(C)n1ncc(CO)c1-n1cccc1.O=S(Cl)Cl>>CC(C)(C)n1ncc(CCl)c1-n1cccc1,,ClCCl,,,,val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(C=O)ccc21.NCCOCCO>>CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CNCCOCCO)ccc21,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070072866A1,C[SiH](C)CCOCn1c(-c2cc(-n3ccnc3)nn(COCC[Si](C)(C)C)c2=O)nc2ccccc21>>O=c1[nH]nc(-n2ccnc2)cc1-c1nc2ccccc2[nH]1,,ClCCl,O=C(O)C(F)(F)F,,,val
US04442096,COC(=O)CN.N#Cc1nccnc1Cl>>COC(=O)CNc1nccnc1C#N,,CCOCC,,CCN(CC)CC,Cl,val
US06313344B1,CCON=C(C(C)=NOCc1ccccc1C(=NOC)C(=O)OC)c1ccc(OC[Si](C)(C)c2ccc(F)cc2)cc1.CN>>CCON=C(C(C)=NOCc1ccccc1C(=NOC)C(=O)NC)c1ccc(OC[Si](C)(C)c2ccc(F)cc2)cc1,,CCO,CO,,,val
US20100256156A1,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.O>>CCc1oc(-c2ccccc2)cc1C=O,,O,,,,val
US05132310,COC(=O)c1cc(C#CC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)ccc1O>>COC(=O)c1cc(CCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)ccc1O,[Pd],CO,,,,val
US20100120757A1,COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.O=C(Cl)CN1CCCC1=O>>COc1ccc(C2=NN(C3CCN(C(=O)CN4CCCC4=O)CC3)C(=O)C2(C)C)cc1OC,,ClCCl,,CCN(CC)CC,Cl,val
US20110319378A1,C=CCBr.O=C1CC[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N1>>C=CC[C@@H]1C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)NC1=O,,C1CCOC1,,[Li]CCCC,,val
US20120015907A1,CCNC(=O)c1c(-c2ccc(F)cc2)oc2nc(N(C)S(C)(=O)=O)c(CCCCC(=O)OCC)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(N(C)S(C)(=O)=O)c(CCCCC(=O)O)cc12,,CO,,[Li+].[OH-],,val
US20090258874A1,COc1ccc(Br)cc1C(O)c1cnc(Cl)nc1Cl>>COc1ccc(Br)cc1C(=O)c1cnc(Cl)nc1Cl,O=[Mn]=O,CC(C)=O,,,,val
US20130331372A1,COc1cc(F)c(C(C)C)cc1B(O)O.C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(Cl)ccc1Br>>COc1cc(F)c(C(C)C)cc1-c1ccc(Cl)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20100069368A1,C[C@@H]1CNCCN1.Clc1nnc(Cc2ccccc2)c2ccccc12>>C[C@@H]1CN(c2nnc(Cc3ccccc3)c3ccccc23)CCN1,,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20110297881A1,CCC[C@@H]1CC[C@@H](C(=O)O)CC1.O=S(Cl)Cl>>CCC[C@@H]1CC[C@@H](C(=O)Cl)CC1,,c1ccncc1,,Cc1ccccc1,,val
US20160052884A1,CCOC(=O)c1ccccc1NC(=O)C(CC1CCOCC1)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O>>COc1cn(C(CC2CCOCC2)C(=O)Nc2ccc(C(=O)O)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N,,CO,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090143353A1,CCOC(=O)COC.Cc1c(C#N)c(N)c(O)c(F)c1-c1ccccc1>>CCOC(=O)c1nc2c(C#N)c(C)c(-c3ccccc3)c(F)c2o1,,CCCCCC,,,,val
US06251911B1,N#Cc1ccccc1C=O.[N-]=[N+]=[N-]>>O=Cc1ccccc1-c1nnn[nH]1,,CN1CCCC1=O,,CCN(CC)CC,Cl,val
US20090082434A1,COc1ccccc1-c1c(Cl)cc(Cl)cc1Cl>>Oc1ccccc1-c1c(Cl)cc(Cl)cc1Cl,,ClCCl,,BrB(Br)Br,,val
US20010039344A1,CO.O=C(O)Cc1cccc(SC(F)(F)F)c1>>COC(=O)Cc1cccc(SC(F)(F)F)c1,O=S(=O)(O)O,,,,,val
US20090275567A1,Cc1ncc(-c2ccnc(NC3CCNCC3)n2)n1C(C)C.O=S(=O)(Cl)CCCCl>>Cc1ncc(-c2ccnc(NC3CCN(S(=O)(=O)CCCCl)CC3)n2)n1C(C)C,,ClCCl,,,,val
US05859007,COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1>>COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1,[Pd],CCO,,O=CO,,val
US05763599,O=C(Cl)Cl.O=[N+]([O-])c1ccccc1CCO>>O=C(Cl)OCCc1ccccc1[N+](=O)[O-],,C1CCOC1,,,,val
US20080293770A1,Nc1cc(Cl)c(Cl)cc1NC1CCN(C2CCOCC2)CC1.O=C(Cl)Cl>>O=c1[nH]c2cc(Cl)c(Cl)cc2n1C1CCN(C2CCOCC2)CC1,,ClCCl,,CCN(CC)CC,,val
US05763460,C[C@H](CN1CC=C(c2cccs2)CC1)Nc1ccccn1.O=C(Cl)C1CC=CCC1>>C[C@H](CN1CC=C(c2cccs2)CC1)N(C(=O)C1CC=CCC1)c1ccccn1,,ClCCl,,,,val
US20080153813A1,Cl.Clc1ccc2ncc(Cl)n2n1.NCCCN1CCOCC1>>Cl.Clc1cnc2ccc(NCCCN3CCOCC3)nn12,,CCOCC,,,,val
US04853404,COc1ccc(C=O)c(Cl)c1Cl>>O=Cc1ccc(O)c(Cl)c1Cl,,ClCCl,,BrB(Br)Br,,val
US20070270587A1,COC[C@@H]1CCCN1.O=C1Nc2ccc(S(=O)(=O)Cl)cc2C1=O>>COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2,,ClC(Cl)Cl,,C1CCOC1,CCN(C(C)C)C(C)C,val
US20100216788A1,CC(C)(C)OC(=O)NCCn1ccc2ncnc(Cl)c21.Nc1ccc2c(ccn2Cc2cscn2)c1>>CC(C)(C)OC(=O)NCCn1ccc2ncnc(Nc3ccc4c(ccn4Cc4cscn4)c3)c21,,CC(C)O,,,,val
US20120226019A1,Cc1ccc(S(=O)(=O)OCCOCCN=[N+]=[N-])cc1.OCCS>>[N-]=[N+]=NCCOCCSCCO,,CO,,[Na+].[OH-],,val
US20120142805A1,C=C(CP(=O)(C(=O)c1c(C)cc(C)cc1C)C(=O)c1c(C)cc(C)cc1C)C(=O)OCC.C=Cc1ccccc1>>C=C(CP(=O)(C(=O)c1c(C)cc(C)cc1C)C(=O)c1c(C)cc(C)cc1C)C(=O)OCC.C=Cc1ccccc1,,Cc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20100210659A1,CS(=O)(=O)N1CCN(C(=O)N2CC(C#N)C(c3ccc(Cl)c(Cl)c3)C2)CC1>>CS(=O)(=O)N1CCN(C(=O)N2CC(CN)C(c3ccc(Cl)c(Cl)c3)C2)CC1,,C1CCOC1,,,,val
US20120178765A1,CC(C)COc1cc(CO)cc(C(=O)Nc2nccs2)c1.O=P(OBr)(OBr)OBr>>CC(C)COc1cc(CBr)cc(C(=O)Nc2nccs2)c1,,C1CCOC1,,,,val
US04254116,CC(=O)OC(C)=O.CCc1cc(O)c2c(c1)OC(C)(C)c1ccncc1-2>>CCc1cc(OC(C)=O)c2c(c1)OC(C)(C)c1ccncc1-2,,c1ccncc1,,,,val
US20120149676A1,CNCC(F)F.CNc1cc(F)c(C(=O)Nc2ccc(F)c(Cl)c2)cc1[N+](=O)[O-]>>CNc1cc(N(C)CC(F)F)c(C(=O)Nc2ccc(F)c(Cl)c2)cc1[N+](=O)[O-],,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US04826818,CCCCCCCCCCCCCCO.N[C@@H](Cc1ccc(O)cc1)C(=O)O>>CCCCCCCCCCCCCCOC(=O)[C@@H](N)Cc1ccc(O)cc1,,Cc1ccccc1,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140256926A1,CCCC[P+](CCCC)(CCCC)CCCCC(CCC(=O)OCC)(Sc1ccccc1)Sc1ccccc1.[Br-]>>CCCC[P+](CCCC)(CCCC)CCCCC(CCC(=O)O)(Sc1ccccc1)Sc1ccccc1.[Br-],,O,,CO,[Na+].[OH-],val
US20070149534A1,BrCCBr.O=[N+]([O-])c1ccc(F)cc1O>>O=[N+]([O-])c1ccc(F)cc1OCCBr,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040044057A1,CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)NCc1c(O[C@H](Cn2ccnc2)c2ccccc2)ccc2c1CCCC2=O>>CSCC[C@H](N)C(=O)NCc1c(O[C@H](Cn2ccnc2)c2ccccc2)ccc2c1CCCC2=O,,C1COCCO1,CO,Cl,,val
US20020032208A1,COC(=O)c1cc(C)nc(Cl)c1>>COC(=O)c1ccnc(C)c1,[Pd],CO,,,,val
US20040058904A1,CC(C)(C)OC(=O)NCc1ccc(N)cc1.Cc1ccccc1N=C=O>>Cc1ccccc1NC(=O)Nc1ccc(CNC(=O)OC(C)(C)C)cc1,,ClCCl,,,,val
US05006544,CN1CCC(=O)c2ccccc21.Cc1c(C=O)ncn1C(c1ccccc1)(c1ccccc1)c1ccccc1>>Cc1[nH]cnc1Cc1cn(C)c2ccccc2c1=O,,CO,,[K+].[OH-],,val
US20090029981A1,CCN.COCCCN1CCOc2ccc(CO[C@H]3CN(C(=O)OCc4ccccc4)C[C@@H](OC[C@H](C)OS(C)(=O)=O)[C@@H]3c3ccc(OC)cc3)cc21>>CCN[C@H](C)CO[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H](OCc2ccc3c(c2)N(CCCOC)CCO3)[C@H]1c1ccc(OC)cc1,,CCO,,,,val
US20090298866A1,CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12.COC(=O)c1cccc(N)c1N>>COC(=O)c1cccc2[nH]c(-c3csc(-n4cc(CC(C)C)c5ccc(Cl)cc54)n3)nc12,,ClCCl,ClCCl,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20040019016A1,COc1cc(CO)cc(Cl)c1OCc1ccccc1.O=S(Cl)Cl>>COc1cc(CCl)cc(Cl)c1OCc1ccccc1,,ClCCl,,CCOCC,O,val
US06492403B1,COC(=S)c1cc(C(N)=S)c(C)s1.Cc1ccc(C(=O)CBr)cc1>>COC(=S)c1cc(-c2nc(-c3ccc(C)cc3)cs2)c(C)s1,,CC(C)=O,,,,val
US06359138B1,Cc1ccc(CC2(O)CCN(CC3Cc4ccc(O)cc4C3)CC2)cc1.Cl>>Cc1ccc(CC2(O)CCN(CC3Cc4ccc(O)cc4C3)CC2)cc1.Cl,,CCO,,,,val
US05118865,Cl[Sn](c1ccccc1)(c1ccccc1)c1ccccc1>>c1ccc([SnH](c2ccccc2)c2ccccc2)cc1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20020156081A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCNCC1>>CC(C)(C)OC(=O)N1CCC(N2CCC(n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1,,ClCCCl,O,CC(=O)O,O=C([O-])O.[Na+],val
US06277871B1,O=C(Cl)CCl.c1ccc(CNCc2nccs2)cc1>>O=C(CCl)N(Cc1ccccc1)Cc1nccs1,,ClCCl,,O=C([O-])O.[Na+],,val
US20080214533A1,CS(=O)(=O)O.Cc1ccc(NC(=O)c2nccnc2C(=O)Nc2ccc(N(C#N)CCO[Si](C)(C)C(C)(C)C)cc2)nc1>>CS(=O)(=O)O.Cc1ccc(NC(=O)c2nccnc2C(=O)Nc2ccc(N3CCOC3=N)cc2)nc1,,CC#N,,,,val
US20140023611A1,COCCN.O=C(Cl)CCBr>>COCCNC(=O)CCBr,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20090082358A1,FC(F)(F)c1ccc([C@H]2NCCc3cccnc32)cc1.N#Cc1cccc(N=C=O)c1>>N#Cc1cccc(NC(=O)N2CCc3cccnc3[C@H]2c2ccc(C(F)(F)F)cc2)c1,,ClCCl,,,,val
US20160264568A1,CI.COC(=O)c1ccc(Br)c(O)c1>>COC(=O)c1ccc(Br)c(OC)c1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20060235033A1,COc1cc2nccc(Oc3ccc(N)c(Cl)c3)c2cc1OC.C[C@H](N)c1ccc(F)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)N[C@@H](C)c4ccc(F)cc4)c(Cl)c3)c2cc1OC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20020103248A1,CC1(Cc2ccccc2)C(=O)Nc2ccc(-c3cccc(Cl)c3)cc21.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC1(Cc2ccccc2)C(=S)Nc2ccc(-c3cccc(Cl)c3)cc21,,Cc1ccccc1,,,,val
US20160076022A1,CN(C)C1=CCC2=C(c3ccc(N4C(=O)C=CC4=O)cc3C(=O)O)c3ccc(N(C)C)cc3OC2=C1>>CN(C)c1ccc2c(-c3ccccc3C(=O)[O-])c3ccc(N(C)C)cc3[o+]c2c1,,CS(C)=O,,,,val
US04639453,Oc1ccc(C2CCCCC2)c(O)c1>>O=C1CCC(C2CCCCC2)C(=O)C1,[Ni],[Na+],[OH-],,,val
US20140228348A1,CCOP(=O)(CC#N)OCC.O=C1CCS(=O)(=O)CC1>>N#CC=C1CCS(=O)(=O)CC1,,C1CCOC1,O,CC(C)(C)[O-].[K+],,val
US20130053397A1,CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)nc2)cc2c1ccn2C(C)C>>CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCNCC3)nc2)cc2c1ccn2C(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US03974157,CC(=O)Cl.CN(C)CCC1(O)CCCCC1c1ccccc1.O=S(=O)(O)NC1CCCCC1>>CC(=O)OC1(CCN(C)C)CCCCC1c1ccccc1.O=S(=O)(O)NC1CCCCC1,,C1CCOC1,,CCN(CC)CC,,val
US06136825,C(=NCC1CCNCC1)c1ccccc1.O=S(=O)(Cl)c1ccccn1>>O=S(=O)(c1ccccn1)N1CCC(CN=Cc2ccccc2)CC1,,ClCCl,,CCN(CC)CC,CCOCC,val
US20090043097A1,Nc1cc(O)nc(SCc2cccc(F)c2F)n1.O=C(Cl)SCl>>Nc1nc(SCc2cccc(F)c2F)nc2oc(=O)sc12,,C1CCOC1,,,,val
US20110183985A1,CC(=O)c1cc(Cl)c2cccnc2c1N1CCNCC1.O=C(Cl)c1ccncc1>>CC(=O)c1cc(Cl)c2cccnc2c1N1CCN(C(=O)c2ccncc2)CC1,,ClCCl,ClCCl,CCN(CC)CC,Cl,val
US20120208819A1,C[C@H](NC(=O)c1nccnc1N)c1ccc(F)c(F)c1.O=C1CCC(=O)N1Br>>C[C@H](NC(=O)c1nc(Br)cnc1N)c1ccc(F)c(F)c1,,CCOC(C)=O,CN(C)C=O,,,val
US20130267499A1,BrCc1ccccc1.CCOC(=O)CCCNc1c(C(=O)OCC)cnn1Cc1ccc(OC)cc1>>CCOC(=O)CCCN(Cc1ccccc1)c1c(C(=O)OCC)cnn1Cc1ccc(OC)cc1,,CN1CCCC1=O,,O,O=C([O-])[O-].[K+].[K+],val
US20030191181A1,CC(=O)Oc1ccc(OCc2ccccc2)c(C(C)(C)C)c1F>>CC(=O)Oc1ccc(O)c(C(C)(C)C)c1F,[Pd],CCOC(C)=O,,,,val
US06066657,COc1cccc2ccoc12.CSSC>>COc1cccc2cc(SC)oc12,,C1CCOC1,,O,[Li]CCCC,val
US20050203094A1,COCC(COC)(C(=O)OC)c1cc(Br)c(O)c(C=O)c1.COCOc1ccc(F)cc1B(O)O>>COCOc1ccc(F)cc1-c1cc(C(COC)(COC)C(=O)OC)cc(C=O)c1O,,COCCOC,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US04217359,CN(C)C(=O)Cl.COC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1>>COC(=O)[C@@H]1C[C@@H](OC(=O)N(C)C)CN1C(=O)OCc1ccccc1,,ClC(Cl)Cl,,,,val
US20020169206A1,CSc1ccc(B(O)O)cc1.Fc1c(F)c(F)c(Br)c(Br)c1F.OB(O)c1ccc(F)cc1>>CSc1ccc(-c2c(F)c(F)c(F)c(F)c2-c2ccc(F)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20070208056A1,CC(C)[C@@H](NC(=O)OCC[Si](C)(C)C)C(=O)N1CCC(O)(c2ccc(Cl)cc2)C2(CC2)C1>>CC(C)[C@@H](N)C(=O)N1CCC(O)(c2ccc(Cl)cc2)C2(CC2)C1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130096133A1,CCOC(=O)CN1CCN(Cc2ccc(C)cc2)CC1.NN>>Cc1ccc(CN2CCN(CC(=O)NN)CC2)cc1,,CCO,,,,val
US20040102634A1,CC(C)O[C@@H](Cc1cccc(CNC(=O)OCc2ccc(NC(=O)OC(C)(C)C)nc2)c1)C(=O)O>>CC(C)O[C@@H](Cc1cccc(CNC(=O)OCc2ccc(N)nc2)c1)C(=O)O,,O=C(O)C(F)(F)F,,,,val
US05344585,CCCCCCCCOc1ccc(-c2ncc(OCCCCCCCC)c(=O)[nH]2)cc1.CCN(CC)S(F)(F)F>>CCCCCCCCOc1ccc(-c2ncc(OCCCCCCCC)c(F)n2)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20020137776A1,CSc1ccc([N+](=O)[O-])c(N(C)C(=O)OC(C)(C)C)c1>>CSc1ccc(N)c(N(C)C(=O)OC(C)(C)C)c1,[Pd],C1CCOC1,CO,,,val
US20100286152A1,CN1CCN(C(C(=O)O)c2ccc3c(c2)OCCO3)CC1.NNc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CN1CCN(C(C(=O)NNc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc3c(c2)OCCO3)CC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20040106626A1,CC(C)(C)OC(=O)Nc1cc(B(O)O)cc([N+](=O)[O-])c1.COC(=O)Cn1c(Br)cnc(NC(C)C)c1=O>>COC(=O)Cn1c(-c2cc(NC(=O)OC(C)(C)C)cc([N+](=O)[O-])c2)cnc(NC(C)C)c1=O,,C1CCOC1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20160222028A1,COC(=O)c1ccc2c(c1)OCC1(CC1)NC2.O=C(Cl)C1CCOCC1>>COC(=O)c1ccc2c(c1)OCC1(CC1)N(C(=O)C1CCOCC1)C2,,ClCCl,,c1ccncc1,,val
US20130315825A1,Nc1ccccc1S.O=[N+]([O-])c1ccc(Cl)c([N+](=O)[O-])c1>>Nc1ccccc1Sc1ccc([N+](=O)[O-])cc1[N+](=O)[O-],,CCO,,[Na+].[OH-],,val
US20090221535A1,CCOC(=O)Cc1cn(CC(=O)OCC)c2cccc(N)c12>>CCOC(=O)Cn1cc2c3c(cccc31)NC(=O)C2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20060234927A1,CCOC(=O)N1CCNCC1.Oc1ccc(CCl)c2cccnc12>>CCOC(=O)N1CCN(Cc2ccc(O)c3ncccc23)CC1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,Cl,val
US20060004052A1,Nc1cc2c3c(c(-c4ccccc4)[nH]c3c1)C=NNC2=O.O=C(O)C/C=C/c1ccccc1>>O=C(C/C=C/c1ccccc1)Nc1cc2c3c(c(-c4ccccc4)[nH]c3c1)C=NNC2=O,,CN(C)C=O,ClCCl,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150299186A1,CC1(C(=O)O)COC1.Nc1cccc([N+](=O)[O-])c1>>CC1(C(=O)Nc2cccc([N+](=O)[O-])c2)COC1,,c1ccncc1,,CCN=C=NCCCN(C)C,Cl,val
US20140213571A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(OCc4ccccc4)c(-c4cc5c(F)cccc5[nH]4)n3)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(O)c(-c4cc5c(F)cccc5[nH]4)n3)cc12,[Pd],CO,,,,val
US05707933,Cc1cc(Oc2cccc(C(=O)O)n2)n(C)n1.Nc1cccc(F)c1>>Cc1cc(Oc2cccc(C(=O)Nc3cccc(F)c3)n2)n(C)n1,,C1CCOC1,,O,O=C(n1ccnc1)n1ccnc1,val
US20040209886A1,Cc1c(NC(=O)CBr)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12.NC(N)=S>>Cc1c(NC2(O)CSC(N)=N2)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12,,CC(C)=O,,,,val
US20060025433A1,C1CCNC1.CC(C)(C)OC(=O)NC1CCC(CNc2nc(NCC(=O)O)ncc2[N+](=O)[O-])CC1>>CC(C)(C)OC(=O)NC1CCC(CNc2nc(NCC(=O)N3CCCC3)ncc2[N+](=O)[O-])CC1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20070219183A1,CN(C)C=CC(=O)c1cccc(NC(=O)c2cccc(C(F)(F)F)c2)c1.Nc1cc[nH]n1>>O=C(Nc1cccc(-c2ccnc3ccnn23)c1)c1cccc(C(F)(F)F)c1,,CC(=O)O,,,,val
US04072499,Nc1cccnc1Cl.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1c1cccnc1Cl,,Clc1ccccc1Cl,,Cc1ccccc1S(=O)(=O)O,,val
US05591752,CC(O)=S.OC1c2ccccc2COc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc21>>CC(=O)SC1c2ccccc2COc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc21,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080146606A1,CCc1cc2c(-c3ccc(S(=O)(=O)NCCN)cc3)ccnc2[nH]1.Cl>>CCc1cc2c(-c3ccc(S(=O)(=O)NCCN)cc3)ccnc2[nH]1.Cl,,CC(C)O,,,,val
US20100267706A1,COC(=O)c1cc(-c2cc(Cl)c(O)c(Cl)c2)nnc1OCCc1ccc(Cl)cc1>>O=C(O)c1cc(-c2cc(Cl)c(O)c(Cl)c2)nnc1OCCc1ccc(Cl)cc1,,C1CCOC1,,[Na+].[OH-],,val
US20150038498A1,CC(C)(C)OC(=O)N1CCN[C@H](C(=O)O)C1.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)[C@H](C(=O)O)C1,,C1COCCO1,O,O=C([O-])O.[Na+],,val
US04758559,CC1(C=O)OCc2ccccc2-n2cccc21.O=C1NCCN1C1CCNCC1>>CC1(CN2CCC(N3CCNC3=O)CC2)OCc2ccccc2-n2cccc21,,CO,,Cl,[BH3-]C#N.[Na+],val
US20120149676A1,CC(C)(C)C(=O)NCc1ccc(Cl)c(N)c1Cl.O=c1ccccn1C(=S)n1ccccc1=O>>CC(C)(C)C(=O)NCc1ccc(Cl)c(N=C=S)c1Cl,,C1COCCO1,,,,val
US20120258946A1,O=C1CCC(=O)N1Br.OCCOCc1ccccc1>>BrCCOCc1ccccc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20020040154A1,COC(=O)CCC[C@H](O)COc1ccc(F)cc1>>O=C1CCC[C@@H](COc2ccc(F)cc2)O1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20080125468A1,COC(=O)c1ccc(Cl)nc1.OB(O)c1ccc(C(F)(F)F)cc1>>COC(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)nc1,,C1COCCO1,,[Cs+].[F-],,val
US20050096360A1,CC(C)(C)OC(=O)N(N)C/C(=C/F)c1ccccc1.Cl>>Cl.NNC/C(=C/F)c1ccccc1,,CO,,C1COCCO1,,val
US20150353488A1,Brc1ccc(Cc2nnn[nH]2)cc1.C[C@@H]1CCCN1CCc1ccc(B(O)O)cc1>>C[C@@H]1CCCN1CCc1ccc(-c2ccc(Cc3nnn[nH]3)cc2)cc1,,C1COCCO1,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20050004134A1,CCOC(=O)c1nc(-c2ccccc2)c(-c2ccc(=O)n(C(C)C)n2)s1.NCc1ccccn1>>CC(C)n1nc(-c2sc(C(=O)NCc3ccccn3)nc2-c2ccccc2)ccc1=O,,C1COCCO1,,O,,val
US20130079313A1,CC(=O)SC(C)(C)C(N)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1.O=S(=O)(Cl)c1ccccc1>>CC(=O)SC(C)(C)C(NS(=O)(=O)c1ccccc1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1,,c1ccncc1,,,,val
US20040254205A1,COc1cc2ncnc(Nc3ccccc3)c2c(N)c1OC.O=CO>>COc1cc2ncnc3c2c(c1OC)N=CN3c1ccccc1,,ClC(Cl)Cl,,[Na+].[OH-],,val
US20140303198A1,CCN(C[C@@H]1CC[C@@H](CC(=O)O)CC1)c1ccc(C(F)(F)F)cc1CN(c1ncc(OCCS(C)(=O)=O)cn1)C(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.OCc1ccccc1>>CCN(C[C@@H]1CC[C@@H](CC(=O)OCc2ccccc2)CC1)c1ccc(C(F)(F)F)cc1CN(c1ncc(OCCS(C)(=O)=O)cn1)C(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,CN(C)c1ccncc1,ClC(Cl)Cl,O,Cl,ClCCl,val
US20010001799A1,CC(=O)OC(C)=O.[H]/N=C(\NO)c1cc(OC)c(OC)cc1C1OCC(C)(C)CO1>>COc1cc(-c2noc(C)n2)c(C2OCC(C)(C)CO2)cc1OC,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US05494925,CCCC1NS(=O)(=O)N(CCl)C1=O.Sc1nnnn1-c1ccccc1>>CCCC1NS(=O)(=O)N(CSc2nnnn2-c2ccccc2)C1=O,,CN(C)C=O,,[Na],,val
US20160024071A1,NNC(=O)c1ccc(Cl)s1.S=C=Nc1ccccc1>>O=C(NNC(=S)Nc1ccccc1)c1ccc(Cl)s1,,CCO,CCO,,,val
US20160108047A1,CCn1c(-c2ccc(OC)nc2)nc2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1>>CCn1c(-c2ccc(OC)nc2)nc2c1C(=O)N(c1cc(C)c(=O)n(C)c1)[C@H]2c1ccc(Cl)cc1,,CCO,,,,val
US20080275085A1,CC1(C)OC(=O)NC1=O.ClCCBr>>CC1(C)OC(=O)N(CCCl)C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20070082912A1,COC(=O)c1cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2)ccc1OC(F)F>>Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1ccc(OC(F)F)c(C(=O)O)c1,,CO,,[Na+].[OH-],,val
US20120289522A1,Cc1noc(-c2ccc(Br)cc2)c1C(=O)CSC(C)(C)C>>Cc1noc(-c2ccc(Br)cc2)c1C(O)CSC(C)(C)C,,C1CCOC1,,B,CSC,val
US20070066624A1,CN(C)C=O.Cc1nc(Cl)ccc1Br>>Cc1nc(Cl)ccc1C=O,,CCOCC,,[Li]CCCC,,val
US20150025058A1,COc1cc(Cl)cc(OC)c1.Nc1nc2c(Cl)nccn2n1.O=C1CNCCN1>>COc1cc(Nc2nc3c(N4CCNC(=O)C4)nccn3n2)cc(OC)c1,,CN(C)C=O,,,,val
US20130023541A1,CC(C)C(=O)Cl.CCN(Cc1ccc(CN2CCN(c3ncccc3CO)CC2)cc1)Cc1c(F)cccc1Cl>>CCN(Cc1ccc(CN2CCN(c3ncccc3COC(=O)C(C)C)CC2)cc1)Cc1c(F)cccc1Cl,,ClCCl,,CCN(CC)CC,CO,val
US20070037812A1,CCOC(=O)CCc1ccc(Oc2cc(O)ccc2C)cc1C.Fc1ccc(C(F)(F)F)cc1Br>>CCOC(=O)CCc1ccc(Oc2cc(Oc3ccc(C(F)(F)F)cc3Br)ccc2C)cc1C,,CS(C)=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20150045368A1,CC1(C)OC(=O)N(c2ccc(-c3ccc(N)nc3)cc2)[C@H]1c1ccccc1.O=C1CCC(=O)N1Br>>CC1(C)OC(=O)N(c2ccc(-c3cnc(N)c(Br)c3)cc2)[C@H]1c1ccccc1,,ClCCl,,,,val
US20130317074A1,CI.COc1cc(N)ccc1-n1nc(C)cc1C>>CNc1ccc(-n2nc(C)cc2C)c(OC)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160052930A1,CC(C)(C)OC(=O)N1[C@H]2CC[C@@H]1CNC2.Clc1ccnc(Cl)n1>>CC(C)(C)OC(=O)N1[C@H]2CC[C@@H]1CN(c1ccnc(Cl)n1)C2,,CO,,,,val
US07518000B2,CC(C)(C)OC(=O)n1nc(-c2c(Br)c3ccc(OCCCBr)cc3n2C(=O)OC(C)(C)C)c2sccc21.OC1CCNCC1>>Brc1c(-c2n[nH]c3ccsc23)[nH]c2cc(OCCCN3CCCCC3)ccc12,,CC#N,,CCN(C(C)C)C(C)C,,val
US20120214785A1,CC(=O)NC(C)Cc1ccc(C#Cc2ccnc(Cl)n2)cc1.CCO>>CCOc1nccc(C#Cc2ccc(CC(C)NC(C)=O)cc2)n1,,C1COCCO1,,[H-].[Na+],,val
US03960904,CC(=O)O[C@H]1CC[C@@]2(C)C(=C(CBr)C[C@H]3[C@@H]4CC[C@H]([C@H](C)CCCC(C)C)[C@@]4(C)CC[C@@H]32)C1.CCOCCNCCOCC>>CCOCCN(CCOCC)CC1=C2C[C@@H](OC(C)=O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]2C1,,O,,ClCCl,,val
US20020198200A1,O=C(Cc1ccc(Cl)c(Cl)c1)Nc1nccs1.O=C(Cl)C1CCCC1>>O=C(Nc1nccs1)C(C(=O)C1CCCC1)c1ccc(Cl)c(Cl)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20130296301A1,COc1ccc(CO[C@@H]2[C@H]3N=C(N(CCOCc4ccccc4)C(=O)OC(C)(C)C)S[C@H]3O[C@H](CO[Si](C)(C)C(C)(C)C)[C@H]2OCc2ccc(OC)cc2)cc1>>COc1ccc(CO[C@@H]2[C@H]3N=C(N(CCOCc4ccccc4)C(=O)OC(C)(C)C)S[C@H]3O[C@H](CO)[C@H]2OCc2ccc(OC)cc2)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160024110A1,CC(C)OC(=O)CC(=O)CCl.CCOC(OCC)OCC>>CCO/C(=C/C(=O)OC(C)C)CCl,O=S(=O)(O)O,ClC(Cl)Cl,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US04656182,CN[C@@H]1CCCC[C@H]1N1CCCCC1.O=C(O)Cc1cccc2sccc12>>CN(C(=O)Cc1cccc2sccc12)[C@@H]1CCCC[C@H]1N1CCCCC1,,C1CCOC1,,O=C(c1ncc[nH]1)c1ncc[nH]1,,val
US05369110,CCCNCc1ccc(-c2ccccc2C#N)cc1.COC(=O)c1cccc(C(=O)O)c1>>CCCN(Cc1ccc(-c2ccccc2C#N)cc1)C(=O)c1cccc(C(=O)O)c1,,ClCCl,,CCN(CC)CC,,val
US20160207949A1,COC(=O)CP(=O)(CC(=O)OC)CC(=O)OC>>O=P(CCO)(CCO)CCO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040038987A1,CC(C)c1cc(O)cc(C(C)C)c1NC(=O)CN1CCN(CCCO)CC1.CCOCCBr>>CCOCCOc1cc(C(C)C)c(NC(=O)CN2CCN(CCCO)CC2)c(C(C)C)c1,,CN(C)C=O,,[F-].[K+],,val
US05136080,CNC.Nc1nc(N)c(-c2ccc(Cl)cc2Cl)c(CBr)n1>>CN(C)Cc1nc(N)nc(N)c1-c1ccc(Cl)cc1Cl,,CCO,,,,val
US20030119855A1,CC(C)(C)OC(=O)NCCCCCC=O.C[Mg]Br>>CC(O)CCCCCNC(=O)OC(C)(C)C,,C1CCOC1,,O,,val
US20100022598A1,Cn1nccc1-c1ccc(C(O)(Cc2nc(CC(C)(C)C)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)C(F)F)cc1>>Cn1nccc1-c1ccc(C(O)(Cc2nc(CC(C)(C)C)c[nH]2)C(F)F)cc1,,CO,,Cl,,val
US04141982,CCCC(=O)c1cc2nc(C(=O)O)n(C)c2cc1C.CCOC(=O)OC(=O)OCC>>CCCC(=O)c1cc2nc(C(=O)OCC)n(C)c2cc1C,,CCOC(C)=O,,CC#N,CCN(CC)CC,val
US04552876,COc1ccc(CCC(=O)CCc2ccc(OC)cc2)cc1>>COc1ccc(CCCCCc2ccc(OC)cc2)cc1,[Zn],O,,C1COCCO1,Cl,val
US20090124604A1,Cc1ccc(C(=O)O)cc1-n1cnc2ccc(N3CCN(C)CC3)cc2c1=O.Nc1ccon1>>Cc1ccc(C(=O)Nc2ccon2)cc1-n1cnc2ccc(N3CCN(C)CC3)cc2c1=O,,c1ccncc1,,O=P(Cl)(Cl)Cl,,val
US20050020660A1,C#CC1(F)CN2CCC1CC2.O=C(c1ccccc1)C1CCCCC1>>OC(C#CC1(F)CN2CCC1CC2)(c1ccccc1)C1CCCCC1,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20140315933A1,Nc1ncns1.O=S(=O)(Cl)c1ccc(F)c(Cl)c1>>O=S(=O)(Nc1ncns1)c1ccc(F)c(Cl)c1,,C1CCOC1,,CCN(CC)CC,,val
US20100130545A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCCC1(O)CC2CCC1C=C2c1ccccc1>>Cc1ccc(S(=O)(=O)OCC[C@]2(O)C[C@H]3CC[C@@H]2C=C3c2ccccc2)cc1,CN(C)c1ccncc1,Cc1ccccc1,,CCN(CC)CC,,val
US20060142333A1,COC(=O)c1ccc(Br)c(O)c1.OB(O)c1ccc(F)cc1>>COC(=O)c1ccc(-c2ccc(F)cc2)c(O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US03931201,CCC(=O)Cl.Nc1ccc(Oc2cccc(Cl)n2)c(Cl)c1>>CCC(=O)Nc1ccc(Oc2cccc(Cl)n2)c(Cl)c1,,O,,c1ccncc1,,val
US04891432,CCOC(=O)C(C)(C)CCCCOc1ccc(OCCCCCBr)cc1.c1nc[nH]n1>>CCOC(=O)C(C)(C)CCCCOc1ccc(OCCCCCn2cncn2)cc1,,CN(C)C=O,,[Na],,val
US20090030176A1,Nc1cccc2nc(-c3ccccc3)c(-c3ccccc3)nc12.O=[N+]([O-])c1ccc(F)cc1>>O=[N+]([O-])c1ccc(Nc2cccc3nc(-c4ccccc4)c(-c4ccccc4)nc23)cc1,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US05470851,CCOC(=O)N(C)CCO.CS(=O)(=O)Cl>>CCOC(=O)N(C)CCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20090209522A1,CCOC(=O)c1coc(Oc2cc(C(C)(C)C)ccc2C)n1>>Cc1ccc(C(C)(C)C)cc1Oc1nc(C(=O)O)co1,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20110269705A1,CCCOc1ccc(F)c2c(=O)c(-c3ccc(OC)cc3)c(C=O)[nH]c12.c1ccc(N2CCNCC2)nc1>>CCCOc1ccc(F)c2c(=O)c(-c3ccc(OC)cc3)c(CN3CCN(c4ccccn4)CC3)[nH]c12,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20130066055A1,CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@]1(C(=O)N2CCCCO2)C[C@@H]1c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCCCCC(=O)O)C(C)C.O=C1CCC(=O)N1O>>CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@]1(C(=O)N2CCCCO2)C[C@@H]1c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCCCCC(=O)ON1C(=O)CCC1=O)C(C)C,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20100056497A1,COc1cc(Cl)c(C=O)cc1OC>>COc1cc(Cl)c(C=O)cc1O,,O,,O=S(=O)(O)O,[Na+].[OH-],val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2(C)C)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nnc(C(F)(F)C(F)(F)C(=O)O)[nH]3)cc2)cc1.Cl>>Cc1cc(C(=O)NC2CCNCC2(C)C)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc(-c3nnc(C(F)(F)C(F)(F)C(=O)O)[nH]3)cc2)cc1.Cl,,C1COCCO1,,CC#N,,val
US20060014778A1,Cl.O=C1Nc2c(cccc2C(F)(F)F)[C@@H]2CN(Cc3ccccc3)C[C@@H]12>>Cl.O=C1Nc2c(cccc2C(F)(F)F)[C@@H]2CNC[C@@H]12,[Pd],CCOCC,CO,[H][H],,val
US20150018343A1,CC(C)(C)OC(=O)N1Cc2n[nH]c(N)c2C1.O=CC(Cl)C=O>>CC(C)(C)OC(=O)N1Cc2nn3cc(Cl)cnc3c2C1,,CC(=O)O,O,,,val
US04035512,CCOC(=O)Cl.COC(=O)c1c(OCc2ccccc2)ccc2c1CC[C@@H](N)[C@@H]2O>>CCOC(=O)N[C@@H]1CCc2c(ccc(OCc3ccccc3)c2C(=O)OC)[C@H]1O,,O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US06180630B2,CCOC(=O)c1n[nH]c2c(c1=O)CCCCC2.Cc1ccc(S(=O)(=O)Cl)cc1>>CCOC(=O)c1nnc2c(c1Cl)CCCCC2,,ClCCl,,c1ccncc1,,val
US20050107377A1,Fc1ccc2c(-c3ccc(OC[C@H]4CO4)cc3)noc2c1.NCc1ccccc1>>OC(CNCc1ccccc1)COc1ccc(-c2noc3cc(F)ccc23)cc1,,CO,ClC(Cl)Cl,CCO,Cl,val
US20040214888A1,C1CCOC1.COc1ccc(-c2cccc(C(=O)O)c2)cc1CCO.Oc1ccc(Cl)cc1Cl>>COC(=O)c1cccc(-c2ccc(OC)c(CCOc3ccc(Cl)cc3Cl)c2)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05391537,CN(C)C(=O)Cl.COC(=O)c1c(OCc2ccccc2)ccc[n+]1[O-]>>COC(=O)c1nc(N(C)C)ccc1OCc1ccccc1,,ClCCl,,,,val
US20090062253A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)Cc1ccc(C(C)(C)C)cc1.NCCCO>>CC(C)(C)OC(=O)N1CCC[C@H]1C(Cc1ccc(C(C)(C)C)cc1)NCCCO,CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C,C1CCOC1,CO,[Na+].[OH-],,val
US20060258719A1,CCC(=O)Cl.Nc1nonc1C(=NO)Nc1ccc(F)c(Cl)c1>>CCC(=O)ON=C(Nc1ccc(F)c(Cl)c1)c1nonc1N,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06069157,CCOC(CC)OCC.N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)cc1C=O>>CCOC(C#CC(O)c1cn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)nc1C#N)OCC,,C1CCOC1,CCOCC,O,[Li]CCCC,val
US20130172302A1,O=C(CCl)c1ccccc1.O=C(O[C@H]1CN2CCC1CC2)C(c1ccccc1)N1CCSCC1>>O=C(C[N+]12CCC(CC1)[C@@H](OC(=O)C(c1ccccc1)N1CCSCC1)C2)c1ccccc1.[Cl-],,CCOC(C)=O,,,,val
US20100144730A1,Clc1ccnc2[nH]cc(Br)c12.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(c1ccccc1)n1cc(Br)c2c(Cl)ccnc21,,C1CCOC1,,[H-].[Na+],,val
US20130065861A1,CCCCCCCCCCCC(=O)OC[C@H](CSC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)OC(=O)CCCCCCCCCCC.CCOP(=O)(CCOCCOCCOCCN)OCC>>CCCCCCCCCCCC(=O)OC[C@H](CSC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)NCCOCCOCCOCCP(=O)(OCC)OCC)OC(=O)CCCCCCCCCCC,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04910201,O=c1c(Cl)c(Cl)cnn1-c1ccc(Cl)cc1.OCc1ccc(Cl)nc1>>O=c1c(Cl)c(OCc2ccc(Cl)nc2)cnn1-c1ccc(Cl)cc1,,CN(C)C=O,,[K+].[OH-],,val
US20150329523A1,COc1cc(N)cc(OCCOCCOCCN(C)C)c1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)cc1>>COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(C)cc4)c4ccccc34)n2)cc(OCCOCCOCCN(C)C)c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20150252057A1,COC(=O)C1=C(CBr)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Cl.O=C1OCCC2CNCCN12>>COC(=O)C1=C(CN2CCN3C(=O)OCCC3C2)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Cl,,CCOC(C)=O,ClCCCl,CCN(C(C)C)C(C)C,,val
US20090124612A1,CCOC(=O)CCc1ccnc2cc(OC)ccc12.NNc1ccc(-c2ccccc2)nn1>>COc1ccc2c(CCc3nnc4ccc(-c5ccccc5)nn34)ccnc2c1,,CS(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20080114007A1,CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCNCC4)cc3)ncc2c1=O.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCN(CC(F)(F)F)CC4)cc3)ncc2c1=O,,ClCCl,,CCN(CC)CC,,val
US20120028939A1,CC(C)Oc1ccc(-c2cc3ncccc3c(Cl)n2)cc1F.NC[C@H]1CNC(=O)C1.O>>CC(C)Oc1ccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)cc1F,,CC(=O)N(C)C,,,,val
US20090203737A1,CC(C)(C)OC(=O)N1CCCC(C(=NO)NC(=O)c2ccn[nH]2)C1>>CC(C)(C)OC(=O)N1CCCC(c2noc(-c3ccn[nH]3)n2)C1,,C1COCCO1,,CCN(CC)CC,,val
US04219559,CC(C)NC1CCN(CCc2ccccc2)CC1.O=[N+]([O-])c1ccccc1N=C=S>>CC(C)N(C(=S)Nc1ccccc1[N+](=O)[O-])C1CCN(CCc2ccccc2)CC1,,CCO,,C1CCOC1,,val
US20100240671A1,CN1CCN(c2cc(-c3ccc4c(c3)CNCC4)nc(N)n2)CC1.O=C(Cl)c1ccc(Cl)cc1>>CN1CCN(c2cc(-c3ccc4c(c3)CN(C(=O)c3ccc(Cl)cc3)CC4)nc(N)n2)CC1,,C1CCOC1,,CCN(CC)CC,Cl,val
US04473568,C1CSCCN1.CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)cc21>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCSCC3)cc21,,CN(C)C=O,,CC#N,,val
US20150266895A1,C[C@@H](NC(=O)Nc1cc2c(cn1)c(NCc1cccnc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccccc1>>C[C@@H](NC(=O)Nc1cc2[nH]nc(NCc3cccnc3)c2cn1)c1ccccc1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20110319424A1,COc1cnc2ccc(=O)n(CCN3CCC(NCc4ccc(Cl)c(Cl)c4)CC3)c2c1.Cl.ClCCl>>COc1cnc2ccc(=O)n(CCN3CCC(NCc4ccc(Cl)c(Cl)c4)CC3)c2c1.Cl.Cl,,ClCCl,,,,val
US06699861B1,C#CCN(Cc1cc2c(=O)[nH]c(COC(C)=O)nc2cc1Cl)c1ccc(C(=O)OC(C)(C)C)cc1>>C#CCN(Cc1cc2c(=O)[nH]c(CO)nc2cc1Cl)c1ccc(C(=O)OC(C)(C)C)cc1,,C1CCOC1,,O,[Na+].[OH-],val
US20070232615A1,O=Cc1cn2c(Br)cccc2n1>>OCc1cn2c(Br)cccc2n1,,CO,,[BH4-].[Na+],,val
US20040259910A1,CCOCCOc1cc2c(C=O)cnc(Cc3cccc(OCC)c3)c2cc1OC.O=[Se]=O>>CCOCCOc1cc2c(C=O)cnc(C(=O)c3cccc(OCC)c3)c2cc1OC,,CCCCCC,CCOC(C)=O,,,val
US20100179109A1,CCc1cccc(-c2c(Cl)cccc2C(O)(CCCNC(=O)OC)[C@@H]2CCCN(C(=O)c3ccc(CN(C)C(=O)OC(C)(C)C)cc3CCc3nnn[nH]3)C2)c1>>CCc1cccc(-c2c(Cl)cccc2C(O)(CCCNC(=O)OC)[C@@H]2CCCN(C(=O)c3ccc(CNC)cc3CCc3nnn[nH]3)C2)c1,,CC#N,,Cl,,val
US20120094981A1,N[C@H]1CC[C@H](O)CC1.O=[N+]([O-])c1ccc(F)cc1C(F)(F)F>>O=[N+]([O-])c1ccc(NC2CCC(O)CC2)cc1C(F)(F)F,,CS(C)=O,ClCCl,,,val
US20050032786A1,CCc1cccc(C#N)n1.COC(=O)c1ccccc1S>>CCc1cccc(-c2nc(=O)c3ccccc3s2)n1,,Cc1ccccc1,,CCN(CC)CC,,val
US08772533B1,CC(=CC=O)C(C)C.C[Mg]Cl>>CC(O)CC(C)C(C)C,,C1CCOC1,,CC(=O)O,,val
US20110039840A1,NC(=O)c1cc(Br)ccc1N.O=C1CCN(Cc2ccccc2)CC1>>O=C1NC2(CCN(Cc3ccccc3)CC2)Nc2ccc(Br)cc21,O=S(=O)(O)O,CC(=O)O,,O=C([O-])O.[Na+],,val
US20050261350A1,CN1C(=O)C2(CC2)c2cc(NC(=O)C(F)(F)F)ccc21.O=[N+]([O-])O>>CN1C(=O)C2(CC2)c2cc(NC(=O)C(F)(F)F)c([N+](=O)[O-])cc21,,CC(=O)O,O,,,val
US20150353488A1,CCOC(=O)COCc1ccc(-c2ccc(CCN3CCC[C@H]3C)cc2)cc1>>C[C@@H]1CCCN1CCc1ccc(-c2ccc(COCC(=O)O)cc2)cc1,,C1CCOC1,CO,O,[Li+].[OH-],val
US20130090460A1,CC(=O)c1cc(C)sc1C.COC(=O)c1ccc(C(C)(C)C)cc1>>Cc1cc(C(=O)CC(=O)c2ccc(C(C)(C)C)cc2)c(C)s1,,C1CCOC1,O,Cl,[H-].[Na+],val
US20150225375A1,COCC1(C(=O)OC)CCN(C(=O)OC(C)(C)C)CC1>>COCC1(CO)CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20020006936A1,O=C1CCCc2cc(OCCn3ccnc3)ccc21.O=Cc1nccs1>>O=C1c2ccc(OCCn3ccnc3)cc2CCC1C(O)c1nccs1,,CC(=O)O,O,O=S(=O)(O)O,,val
US20040142989A1,CN(c1ccc(CNC(=O)OC(C)(C)C)cc1)c1ccc(C(F)(F)F)cc1NC(=O)c1cc(Cl)c(Cl)cc1C(=O)O>>CN(c1ccc(CN)cc1)c1ccc(C(F)(F)F)cc1NC(=O)c1cc(Cl)c(Cl)cc1C(=O)O,,CO,,Cl,,val
US20150065705A1,CC(C)(C)OC(=O)N1CC=C(c2ccc(F)cc2)C(N2C(=O)c3ccccc3C2=O)C1>>CC(C)(C)OC(=O)N1CC=C(c2ccc(F)cc2)C(N)C1,,CCO,,NN,O,val
US20060052349A1,COc1ccc2cc(-c3ccc(-c4ccccc4)n3C)ccc2c1>>Cn1c(-c2ccccc2)ccc1-c1ccc2cc(O)ccc2c1,,CCOC(C)=O,,Cl,c1ccncc1,val
US20080004271A1,Cc1ccc(N=C=O)cc1.NC(=O)c1sc2nc(NC3CC3)nc(-c3cccc(N)c3)c2c1N>>Cc1ccc(NC(=O)Nc2cccc(-c3nc(NC4CC4)nc4sc(C(N)=O)c(N)c34)c2)cc1,,C1CCOC1,,,,val
US20130274244A1,C[C@H]1CN(CCO)C[C@@H](C)N1C.Cc1nn(Cc2cccc(C(C)C)n2)c2cccc(NC(=O)c3cnc4cc(Cl)ccn34)c12>>Cc1nn(Cc2cccc(C(C)C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5C[C@H](C)N(C)[C@H](C)C5)ccn34)c12,,CS(C)=O,O,[K+].[OH-],,val
US05808062,CCN(CC)CC.C[Si](C)(C)OS(=O)(=O)C(F)(F)F.ClCCl.O=C(O)C(Sc1ccccc1CC1CC1)C(=O)O>>Cc1cc(C)cc(-c2cc(O)c(Sc3ccccc3CC3CC3)c(=O)o2)c1,,ClCCl,,,,val
US06156787,CC1(C)CC(=O)c2c(S(C)(=O)=O)sc(C(=O)N3CCCC3)c2C1.Sc1nccs1>>CC1(C)CC(=O)c2c(Sc3nccs3)sc(C(=O)N3CCCC3)c2C1,,CCO,,[Na+].[OH-],,val
US20040259891A1,CCOc1ccc(-c2nc(SC)c(C#N)c(=O)n2-c2ccccc2)cc1.O=S(=O)(O)Cl>>CCOc1ccc(-c2nc(SC)c(C#N)c(=O)n2-c2ccc(S(=O)(=O)Cl)cc2)cc1,,ClC(Cl)Cl,,,,val
US20150166564A1,COCCN1C[C@@H](NC(=O)Nc2c(C)c(OC[C@H](COC)O[Si](C)(C)C(C)(C)C)nn2-c2ccccc2)[C@H](c2cc(F)c(F)c(F)c2)C1>>COCCN1C[C@@H](NC(=O)Nc2c(C)c(OC[C@@H](O)COC)nn2-c2ccccc2)[C@H](c2cc(F)c(F)c(F)c2)C1,,C1CCOC1,,Cl,,val
US20050107364A1,CC(C)(C)CCCCC1(C)C(=O)C(C2=NS(=O)(=O)c3cc(NC(=O)OC(C)(C)C)ccc3N2)=C(O)c2ccccc21.Cl>>CC(C)(C)CCCCC1(C)C(=O)C(C2=NS(=O)(=O)c3cc(N)ccc3N2)=C(O)c2ccccc21.Cl,,C1COCCO1,,,,val
US20090069222A1,NCc1ccccc1.O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)OCc1ccccc1>>O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1)OCc1ccccc1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05580986,Br.Cn1nc(-n2ncc(C#N)c2N)c(Cl)c1OC(F)F>>Cn1nc(-n2ncc(C#N)c2Br)c(Cl)c1OC(F)F,,O,,O=N[O-].[Na+],,val
US04892872,CI.COC(=O)c1cc(Cl)cc2c1OC(C)(C)C(=O)N2>>CN1C(=O)C(C)(C)Oc2c(C(=O)O)cc(Cl)cc21,,CCOC(C)=O,CN(C)C=O,O,CC(C)(C)[O-].[K+],val
US20120184508A1,NN.O=C(c1cccc(Br)c1)c1cnc(Cl)nc1Cl>>Clc1ncc2c(-c3cccc(Br)c3)n[nH]c2n1,,C1CCOC1,,,,val
US05532397,CC(C)(C)ONC(C(=C=O)c1ccccc1)[Si](C)(C)C.Cl>>C[Si](C)(C)C(N)Cc1ccccc1.Cl,,CCOCC,,,,val
US20080103123A1,CC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.CC(C)(C)OC(=O)N1CCC(COc2ccc(Cl)nc2)CC1>>CC(=O)Nc1ccc(-c2ccc(OCC3CCN(C(=O)OC(C)(C)C)CC3)cn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20090298807A1,CC(C)(C)[Si](C)(C)OCCBr.O=C(O)c1cccc(S)c1>>CC(C)(C)[Si](C)(C)OCCSc1cccc(C(=O)O)c1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20100135999A1,COC(=O)c1cc(OCC(=O)N2CCC[C@H]2C#N)c2ccc(C)cc2n1>>Cc1ccc2c(OCC(=O)N3CCC[C@H]3C#N)cc(C(=O)O)nc2c1,,C1CCOC1,,[Na+].[OH-],,val
US20120309750A1,CC(=O)OC(C)=O.CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1-c1noc(C)n1>>CCNC(=O)c1noc(-c2cc(C(C)C)c(OC(C)=O)cc2OC(C)=O)c1-c1noc(C)n1,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,CCOC(C)=O,val
US04260623,CI.c1ccc(C2OC3(CCNCC3)N3CCCCC23)cc1>>CN1CCC2(CC1)OC(c1ccccc1)C1CCCCN12,,C1CCOC1,,[H-].[Na+],,val
US20080262023A1,O=C1C2CC3CC1CN(C3)C2.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>N#CC1C2CC3CC1CN(C3)C2,,CCO,COCCOC,CC(C)(C)[O-].[K+],,val
US05635477,COC(=O)c1ccc2c(c1)C(C#N)=CCC2>>COC(=O)c1ccc2cccc(C#N)c2c1,,C1COCCO1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20100305122A1,CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@@H](CO)CC1.NS(=O)(=O)c1ccc(F)c(Cl)c1>>NS(=O)(=O)c1ccc(OC[C@@H]2CC[C@@H](O)CC2)c(Cl)c1,,C1CCOC1,,[H-].[Na+],,val
US20060142211A1,COc1cc2oc(-c3ccc(OCc4ccccc4)cc3)cc(=O)c2c(OC)c1OC>>COc1cc2oc(-c3ccc(O)cc3)cc(=O)c2c(OC)c1OC,[Pd],CCO,,,,val
US20140171390A1,COC(=O)CC1CC(=O)C1.COc1ccc(CN)c(OC)c1>>COC(=O)CC1CC(NCc2ccc(OC)cc2OC)C1,[Pd],CO,,,,val
USH0001942H1,C=CC(=O)OCC.Cl.Cn1nc(-c2cc(N)c(Cl)cc2F)c(Cl)c1OC(F)F>>CCOC(=O)C(Cl)Cc1cc(-c2nn(C)c(OC(F)F)c2Cl)c(F)cc1Cl,Cl[Cu]Cl,CC#N,,CC(C)(C)ON=O,,val
US20100035756A1,CCOC(=O)c1ccc(C(F)(F)F)nc1NNC=O>>CCOC(=O)c1ccc(C(F)(F)F)n2cnnc12,,Cc1ccccc1,,O=P(Cl)(Cl)Cl,O=C([O-])O.[Na+],val
US06235771B1,CCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CCS3(=O)=O)cc1.Cl>>CCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CCS3(=O)=O)cc1.Cl,,C1CCOC1,,,,val
US20090042925A1,Cc1c(C)n2nnnc2c2nc(CCl)n(CCCCNS(C)(=O)=O)c12.O=C1c2ccccc2C(=O)N1O>>Cc1c(C)n2nnnc2c2nc(CON3C(=O)c4ccccc4C3=O)n(CCCCNS(C)(=O)=O)c12,,CN(C)C=O,,CCN(CC)CC,,val
US20110274638A1,CCCCOC1(c2ccccc2C)CN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)OC(C)(C)C)C1.Cl>>CCCCOC1(c2ccccc2C)CN(C(=O)[C@H](N)Cc2ccc(OC)cc2)C1.Cl,,CCOC(C)=O,,,,val
US20120040950A1,COC1c2nc(Cl)ccc2C(=O)N1c1cnn(CC(F)(F)F)c1.COc1cc(B2OC(C)(C)C(C)(C)O2)cnc1OC>>COc1cc(-c2ccc3c(n2)C(OC)N(c2cnn(CC(F)(F)F)c2)C3=O)cnc1OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20040102435A1,CI.COc1ccc(C(=O)Nc2ccc(O)cc2Cl)cc1>>COc1ccc(C(=O)Nc2ccc(OC)cc2Cl)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20030069419A1,CCCC(O)c1ccc(OC(C)(C)C)cc1.CS(=O)(=O)Cl>>CC(C)(C)Oc1ccc(CCCCOS(C)(=O)=O)cc1,,O,,CCN(CC)CC,CCOC(C)=O,val
US20110218177A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN[C@@H](C)[C@H](O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN(C(=O)OC(C)(C)C)[C@@H](C)[C@H](O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CC#N,CCOCC,CCN(C(C)C)C(C)C,,val
US20020032208A1,COC(=O)c1ccnc(C)c1>>Cc1cc(CO)ccn1,,CCOCC,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20110092547A1,COC(=O)C(=O)Nc1ccc(Oc2ccc(C(=O)OC)cc2)nc1.NN>>COC(=O)c1ccc(Oc2ccc(NC(=O)C(=O)NN)cn2)cc1,,CCO,,O,,val
US20050059650A1,CC(C)Oc1ccc(N2CCC(O)CC2)nc1.CS(=O)(=O)c1ccc(-n2ncc3c(Cl)ncnc32)c(F)c1>>CC(C)Oc1ccc(N2CCC(Oc3ncnc4c3cnn4-c3ccc(S(C)(=O)=O)cc3F)CC2)nc1,,ClCCl,,C1CCOC1,[H-].[Na+],val
US20060106037A1,CC(O)C(CCCc1ccccc1)n1cnc(C(N)=O)c1N.CCOC(=O)Cc1ccc(Cl)c(OC(F)F)c1>>CC(O)C(CCCc1ccccc1)n1cnc2c(=O)[nH]c(Cc3ccc(Cl)c(OC(F)F)c3)nc21,,CCO,,[Na],,val
US05817829,CCOC(=O)/C=C(/C)N.O=C(Cl)SCl>>CCOC(=O)c1sc(=O)[nH]c1C,,Cc1ccccc1,,,,val
US20040147612A1,CS(=O)(=O)NCCc1ccc2cc(OCCN)ccc2c1.O=S(=O)(Cl)c1ccccc1>>CS(=O)(=O)NCCc1ccc2cc(OCCNS(=O)(=O)c3ccccc3)ccc2c1,,ClCCl,,CCN(CC)CC,,val
US05789405,CCCCN=C=O.COC1C(OC(=O)N2CCOCC2)CCC2(CO2)C1C1(C)OC1CCO>>CCCCNC(=O)OCCC1OC1(C)C1C(OC)C(OC(=O)N2CCOCC2)CCC12CO2,,C1CCOC1,CCOCC,[H-].[Na+],,val
US20050233988A1,CON(C)C(=O)c1cc(Br)ccc1C>>Cc1ccc(Br)cc1C=O,,C1CCOC1,,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US20130143940A1,COc1nn(C)c(-c2c(F)cccc2F)c1C=O.Cc1cc(F)ccc1[Mg]Br>>COc1nn(C)c(-c2c(F)cccc2F)c1C(O)c1ccc(F)cc1C,,C1CCOC1,,,,val
US20150031679A1,COC(=O)c1ccc2[nH]c(=O)c(N3CCC[C@@H]3C)nc2c1.O=S(Cl)Cl>>COC(=O)c1ccc2nc(Cl)c(N3CCC[C@@H]3C)nc2c1,,CN(C)C=O,,Cc1ccccc1,,val
US20090324581A1,CC(C)(C)OC(=O)C[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CCOc2cc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)ccc21.Cl>>Cl.N[C@H](CC(=O)O)C(=O)N1CCOc2cc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)ccc21,,C1COCCO1,,,,val
US20090023773A1,CI.O=[N+]([O-])c1ccc(F)cc1O>>COc1cc(F)ccc1N,[Pd],CC(C)=O,CO,O=C([O-])[O-].[K+].[K+],,val
US20130131050A1,CC(C)(C)OC(=O)NCCSc1nc2cscc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1.Cl>>Cl.NCCSc1nc2cscc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1,,CO,,CCOC(C)=O,,val
US20150087828A1,COc1ccc(CNCCO)c(OC)c1.O=CC(=O)O>>COc1ccc(CN2CCOC(O)C2=O)c(OC)c1,,C1CCOC1,,O,,val
US20120035237A1,Nc1c(F)cccc1F.O=C(Cl)c1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1>>O=C(Nc1c(F)cccc1F)c1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1,,ClCCl,,CCN(CC)CC,,val
US20100124037A1,CC(=O)OC(C)=O.CN(C)C=O.Nc1ccccc1O.O=C(O)c1ccc2cc(O)ccc2c1.O=C(O)c1cccc(C(=O)O)c1>>C#C.O=C(O)c1ccccc1.O=C(O)c1ccccc1.O=C(O)c1ccccc1N1C(=O)C=CC1=O.O=C1C=CC(=O)N1,,CN(C)C=O,,,,val
US20090163586A1,COc1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)c(S(N)(=O)=O)c1>>NS(=O)(=O)c1cc(O)ccc1NS(=O)(=O)c1cccc(Cl)c1Cl,,ClCCl,,BrB(Br)Br,,val
US20100298384A1,N#CCn1cncn1.NO>>N=C(Cn1cncn1)NO,,CCO,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20070021454A1,COC(=O)c1ccc2ccn(C(C)C)c2c1>>CC(C)n1ccc2ccc(CO)cc21,,C1CCOC1,,[BH4-].[Li+],,val
US20090012077A1,CC(C)(C)OC(=O)N1CCc2[nH]c3ccccc3c2C1.COC(=O)CBr>>COC(=O)Cn1c2c(c3ccccc31)CN(C(=O)OC(C)(C)C)CC2,,CN(C)C=O,,[H-].[Na+],,val
US20150291600A1,CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3cccc(NC(=O)C=CCBr)c3)nc12.CNC>>CN(C)CC=CC(=O)Nc1cccc(-c2cnc3c(n2)c(C(=O)NC(C)(C)C)cn3COCC[Si](C)(C)C)c1,,C1CCOC1,,O,,val
US20160145247A1,CC(C)(C)OC(=O)Cc1ccccc1N.O=C(O)c1cc(Br)cc(Br)c1>>CC(C)(C)OC(=O)Cc1ccccc1NC(=O)c1cc(Br)cc(Br)c1,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20120101083A1,CCCN.COC(=O)c1cnc(Cl)c(C#N)c1>>CCCNc1ncc(C(=O)OC)cc1C#N,,CO,,CCN(CC)CC,,val
US20040110741A1,CN1CCNCC1.NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3ccnc(Cl)c3)cc1-2>>CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)ccn2)CC1,,CC(=O)N(C)C,,O,,val
US05972943,COCOCCCCCCCCCCCCCCCCN>>NCCCCCCCCCCCCCCCCO,,CO,,Cl,,val
US20040254227A1,O=[N+]([O-])c1cccc(C2=NOC(c3c(Cl)cccc3Cl)C2)c1>>Nc1cccc(C2=NOC(c3c(Cl)cccc3Cl)C2)c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20060004084A1,COC(Cc1ccc2c(c1)C(C)(C)OC2=O)OC.O=C1Cc2cc(F)ccc2N1>>COC(Cc1ccc2c(c1)C(C)(C)OC2=C1C(=O)Nc2ccc(F)cc21)OC,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20130018043A1,CC(C)(C)OC(=O)N1CCC(NC(=O)NCc2cn(-c3ccccc3)c3cc(Cl)ccc3c2=O)CC1.Cl>>Cl.O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)NC1CCNCC1,,C1COCCO1,,,,val
US20060166278A1,CCN(CC)S(F)(F)F.O=C(CCl)OC[C@H]1O[C@@H](Sc2ccccc2)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@H]1OCc1ccccc1>>O=C(CCl)OC[C@H]1O[C@@H](F)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@H]1OCc1ccccc1,,ClCCl,,O=C1CCC(=O)N1Br,,val
US20150119362A1,CCc1c(C)nc(-c2ccc(Cl)s2)nc1OS(=O)(=O)C(F)(F)F.Nc1ccc2c(c1)B(O)OC2>>CCc1c(C)nc(-c2ccc(Cl)s2)nc1Nc1ccc2c(c1)B(O)OC2,,O,,CS(C)=O,,val
US20080275035A1,C1=COCCC1.CC(C)(C)[Si](C)(C)OC[C@@H](O)Cn1cc([N+](=O)[O-])nc1Cl>>CC(C)(C)[Si](C)(C)OC[C@H](Cn1cc([N+](=O)[O-])nc1Cl)OC1CCCCO1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20050227995A1,CCC=O.O=Cc1cc(F)ccc1F>>CC(C=O)=Cc1cc(F)ccc1F,,CCO,CCOC(C)=O,[Na+].[OH-],,val
US20040110754A1,CON(C)C(=O)C=Cc1ccc(F)cc1.C[S+](C)(C)=O>>CON(C)C(=O)C1CC1c1ccc(F)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20010014680A1,COc1ccccc1N1CCN(CC2CCNCC2)CC1.O=C(Cl)C1CCCCC1>>COc1ccccc1N1CCN(CC2CCN(C(=O)C3CCCCC3)CC2)CC1,,ClCCl,,CCN(CC)CC,,val
US20160052940A1,CI.O=C(OCc1ccccc1)N1CCC(F)(CO)C1>>COCC1(F)CCN(C(=O)OCc2ccccc2)C1,,C1CCOC1,,[H-].[Na+],,val
US07396844B1,CCOC(=O)C[C@H](COc1cccc(C(=N)N)c1)NC(=O)c1ccc(-c2ccccc2)cc1.O=C(O)C(F)(F)F>>N=C(N)c1cccc(OC[C@@H](CC(=O)O)NC(=O)c2ccc(-c3ccccc3)cc2)c1.O=C(O)C(F)(F)F,,Cl,,,,val
US20070155805A1,CCCCC(CCBr)c1sc2cc(C(F)(F)F)ccc2c1C.COC(=O)CCc1ccc(O)cc1>>CCCCC(CCOc1ccc(CCC(=O)OC)cc1)c1sc2cc(C(F)(F)F)ccc2c1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05998649,C#C.Cl[SiH](Cl)C[SiH](Cl)Cl>>Cl[Si]1(Cl)C=C[Si](Cl)(Cl)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,c1ccccc1,,,,val
US20110308592A1,O=C(Cc1ccccc1)Cc1ccccc1.O=C1C(=O)c2cccc3cccc1c23>>O=C1C(c2ccccc2)=C2c3cccc4cccc(c34)C2C1c1ccccc1,,CCO,Cc1ccccc1,[K+].[OH-],,val
US20110071126A1,C[Si](C)(C)C#N.O=Cc1cc(Br)ccc1F>>C[Si](C)(C)OC(C#N)c1cc(Br)ccc1F,CN(C)c1ccncc1,,,CC#N,,val
US20040072871A1,COC(=O)c1ccc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nc1>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ccc(CO)cn1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US08022075B2,CC(=O)c1ccc(-c2cn3cc(I)ccc3n2)cc1.COC(OC)N(C)C>>CN(C)/C=C/C(=O)c1ccc(-c2cn3cc(I)ccc3n2)cc1,,CN(C)C=O,,,,val
US20090029903A1,CCCCc1ccc(C#Cc2ccc(C(=O)OC)cc2)cc1>>CCCCc1ccc(C#Cc2ccc(C(=O)O)cc2)cc1,,CO,,O,[Li+].[OH-],val
US20140024666A1,CCOC(=O)CN=C=O.O=C1CC(=O)N(c2cccc([N+](=O)[O-])c2)C(=O)N1CCC1CC1>>O=C(O)CNC(=O)c1c(O)n(CCC2CC2)c(=O)n(-c2cccc([N+](=O)[O-])c2)c1=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150218131A1,CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(N)cc2)C1.COc1cccc(-n2cc(C(=O)O)cn2)n1>>COc1cccc(-n2cc(C(=O)Nc3ccc([C@H]4CN(C(=O)OC(C)(C)C)CCO4)cc3)cn2)n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20130252944A1,COc1ccc(Cn2cc3c(n2)C(C)(C)OCc2sc(Nc4nccc(C)n4)nc2-3)cc1>>Cc1ccnc(Nc2nc3c(s2)COC(C)(C)c2n[nH]cc2-3)n1,,O,O=C(O)C(F)(F)F,,,val
US20150056141A1,CCOC(=O)c1c(NC(C)=O)sc2c(OCCN(CC)CC)c(Br)ccc12.OB(O)c1ccc(C(F)(F)F)cc1>>CCOC(=O)c1c(NC(C)=O)sc2c(OCCN(CC)CC)c(-c3ccc(C(F)(F)F)cc3)ccc12,,CC#N,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20120178751A1,CCc1ccc(-c2cn3nc(Cl)ccc3n2)cc1[N+](=O)[O-]>>CCc1ccc(-c2cn3nc(Cl)ccc3n2)cc1N,[Fe],CCO,O,CC(=O)O,,val
US20150361059A1,N#Cc1ccccc1-n1ccc2c(C=O)cccc21>>N#Cc1ccccc1-n1ccc2c(CO)cccc21,,CCO,ClCCl,[BH4-].[Na+],,val
US20070161685A1,CC#N.CC(C)(C)[S@](=O)N=C(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1>>CC(C)(C)[S@](=O)N[C@](CC#N)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1,,CCOCC,,CC(C)[N-]C(C)C.[Li+],,val
US04093631,CC(=O)O.O=C1CC(c2cccc3ccccc23)c2ccc(O)cc2O1.[Li]C>>CC1(C)CC(c2cccc3ccccc23)c2ccc(O)cc2O1,,CC(=O)O,,CCOCC,,val
US20120071461A1,CN(C)c1ccc(N2CCC(N(C)C(=O)OCc3ccccc3)CC2)cn1>>CNC1CCN(c2ccc(N(C)C)nc2)CC1,,CO,,,,val
US20100135999A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.NC1CCC1>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NC1CCC1,,CN(C)C=O,O,ClCCCl,On1nnc2cccnc21,val
US20020026056A1,O=C(C(=NO)c1ccnc(F)c1)c1cccc(C(F)(F)F)c1>>NC(c1ccnc(F)c1)C(O)c1cccc(C(F)(F)F)c1,[Pd],CCO,,,,val
US20060173008A1,CCn1nc(-c2ccccc2)c(C(C)=O)c([N+](=O)[O-])c1=O.Nc1cnccn1>>CCn1nc(-c2ccccc2)c(C(C)=O)c(Nc2cnccn2)c1=O,,CCO,,,,val
US20100273850A1,COC(=O)Cc1ccc(-n2ccc3cc(C(=O)O)ccc32)c(C#N)c1.NCCc1ccc(Cl)cc1Cl>>COC(=O)Cc1ccc(-n2ccc3cc(C(=O)NCCc4ccc(Cl)cc4Cl)ccc32)c(C#N)c1,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20100331297A1,CN1CC[C@H](O)C1.Nc1ncnc2[nH]nc(I)c12>>CN1CCC(n2nc(I)c3c(N)ncnc32)C1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04343945,COc1ccc(C(=O)Cl)cc1.Nc1nc(C(Cl)(Cl)Cl)ns1>>COc1ccc(C(=O)Nc2nc(C(Cl)(Cl)Cl)ns2)cc1,,Cc1ccccc1C,,,,val
US20120184587A1,C#Cc1cc(C(=O)O)cc(C#N)c1OC.O=C(Cl)C(=O)Cl>>C#Cc1cc(C(=O)Cl)cc(C#N)c1OC,,CN(C)C=O,,Cc1ccccc1,,val
US04743692,ClP(Cl)(Cl)(Cl)Cl.O=C1NS(=O)(=O)c2cc(-c3ccccn3)ccc21>>O=S1(=O)N=C(Cl)c2ccc(-c3ccccn3)cc21,,COCCOCCOC,,,,val
US05062884,O=Cc1ccccc1Br.O=[N+]([O-])O>>O=Cc1cc([N+](=O)[O-])ccc1Br,,O=S(=O)(O)O,,,,val
US20050215614A1,Cc1cn(C(=O)c2c(Cl)cccc2Cl)c2ccc([N+](=O)[O-])cc12>>Cc1cn(C(=O)c2c(Cl)cccc2Cl)c2ccc(N)cc12,[Fe],CCO,O,[Cl-].[NH4+],,val
US20040142850A1,CCOC(=O)N(c1cccc(Cl)c1)c1c(N)cc(N)cc1C(F)(F)F>>Nc1cc(C(F)(F)F)c2c(c1)[nH]c(=O)n2-c1cccc(Cl)c1,,CCO,,[H-].[Na+],,val
US20140100231A1,CCOC(=O)c1cnc(C(C)(C)C)nc1OC>>COc1nc(C(C)(C)C)ncc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100093730A1,FC(F)(F)c1ccc2c(c1)CNC2.O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O>>O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)N1Cc2ccc(C(F)(F)F)cc2C1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20090215776A1,Brc1cncc(-c2cc(NC3CC3)nc(-c3ccccn3)c2)c1.CC1(C)OB(c2ccc(C(=O)N3CCNCC3)cc2)OC1(C)C>>O=C(c1ccc(-c2cncc(-c3cc(NC4CC4)nc(-c4ccccn4)c3)c2)cc1)N1CCNCC1,,COCCOC,ClCCl,O=C([O-])[O-].[Na+].[Na+],,val
US20060241302A1,O=S(=O)(c1ccc(Cl)cc1)C(c1cccc(/C=C/c2ccccn2)n1)c1cc(F)ccc1F>>O=S(=O)(c1ccc(Cl)cc1)C(c1cccc(CCc2ccccn2)n1)c1cc(F)ccc1F,[Ni],C1COCCO1,CCO,CCCCCC,CCOC(C)=O,val
US20070117816A1,CC(=O)n1cc(C=O)c2c(Br)cccc21.O=C(OO)c1cccc(Cl)c1>>CC(=O)N1CC(=O)c2c(Br)cccc21,,ClCCl,,,,val
US20080262041A1,CC#N.C[C@@H](c1cc(Cl)cc2ccccc12)N1CC=C(C2(c3ccc(F)cc3)CCNCC2)C1=O>>C[C@@H](c1cc(Cl)cc2ccccc12)N1CC=C(C2(c3ccc(F)cc3)CCN(C)CC2)C1=O,,CC#N,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160052888A1,COc1ccccc1CCl.Sc1nnnn1-c1ccccc1>>COc1ccccc1CSc1nnnn1-c1ccccc1,,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20120034270A1,CC(C)(C)OC(=O)NC1(C#Cc2ccc(C#CCn3cc(C(=O)C(F)(F)F)c4ccccc43)cc2)COC(C)(C)OC1>>CC(C)(C)OC(=O)NC1(CCc2ccc(CCCn3cc(C(=O)C(F)(F)F)c4ccccc43)cc2)COC(C)(C)OC1,[Pd],,,,,val
US20100240702A1,CC(C)(C)OC(=O)Oc1cc2c(CO)cc(Br)cc2n1C(=O)OC(C)(C)C.CCCC(CC(=O)OCC)n1c(=O)[nH]c2ccccc21>>CCCC(CC(=O)OC)n1c(=O)n(Cc2cc(Br)cc3c2cc(OC(=O)OC(C)(C)C)n3C(=O)OC(C)(C)C)c2ccccc21,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100261755A1,CCOC(=O)CC(=O)[C@H]1CCN(C(=O)OC)[C@@H](CC2CCC(F)(F)CC2)C1.NO>>COC(=O)N1CC[C@H](c2cc(=O)[nH]o2)C[C@@H]1CC1CCC(F)(F)CC1,,CO,O,Cl,[Na+].[OH-],val
US20160222033A1,CCC(=O)c1c(C)sc2nc(COc3ccc(F)cc3)cc(=O)n12>>CCC(O)c1c(C)sc2nc(COc3ccc(F)cc3)cc(=O)n12,,CO,,[BH4-].[Na+],,val
US20140343053A1,C=Cc1ccc2ccccc2n1.O=c1[nH]nc2c(Br)cccn12>>O=c1n(CCc2ccc3ccccc3n2)nc2c(Br)cccn12,,CN1CCCC1=O,ClCCl,[K+].[OH-],,val
US20100239872A1,O=[Sb](=O)O[Sb](=O)=O.O=[Sn].O=[W].[O-2].[O-2].[O-2].[O-2].[Ti+4].[Zr+4]>>O=[Sb](=O)O[Sb](=O)=O.O=[Sn].O=[W].[O-2].[O-2].[O-2].[O-2].[Ti+4].[Zr+4],,O,,,,val
US20090137541A1,CC(=O)O[C@@H]1CC2=CC(=NO)[C@H]3[C@@H]4CCC[C@@]4(C)CC[C@@H]3[C@@]2(C)[C@H](OC(C)=O)C1.ClCCCBr>>CC(=O)O[C@@H]1CC2=CC(=NOCCCCl)[C@H]3[C@@H]4CCC[C@@]4(C)CC[C@@H]3[C@@]2(C)[C@H](OC(C)=O)C1,,CCC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100222303A1,CCOC(CN)OCC.O=Cc1cccc2cn[nH]c12>>CCOC(CNCc1cccc2cn[nH]c12)OCC,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20100048636A1,CC(C)(C)OC(=O)N1[C@@H](C[C@@H](CCO)CO[Si](C)(C)C(C)(C)C)COC1(C)C.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1[C@@H](C[C@@H](CCOS(C)(=O)=O)CO[Si](C)(C)C(C)(C)C)COC1(C)C,,ClCCl,,,,val
US20140066424A1,BrCc1cccc(Br)c1.Cc1nc(C(N)=O)n[nH]1>>Cc1nc(C(N)=O)nn1Cc1cccc(Br)c1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20150250169A1,COCC(=O)CC(=O)OC.C[Si](C)(C)Cl>>COCC(=CC(=O)OC)O[Si](C)(C)C,,c1ccccc1,,CCN(CC)CC,,val
US09284307B2,COC(=O)[C@@]12C[C@H]1C=CCCCCN(C)C(=O)[C@@H]1CC[C@@H](O)C[C@H]1C(=O)N2.O=S(=O)(Cl)c1ccc(Br)cc1>>COC(=O)[C@@]12C[C@H]1C=CCCCCN(C)C(=O)[C@@H]1CC[C@@H](OS(=O)(=O)c3ccc(Br)cc3)C[C@H]1C(=O)N2,CN(C)c1ccncc1,ClCCl,,,,val
US20120129840A1,COC(=O)Cc1c(C)nc(N2CCCCC2)nc1-c1ccc(C)cc1.COCCBr>>COCCC(C(=O)OC)c1c(C)nc(N2CCCCC2)nc1-c1ccc(C)cc1,,CN(C)C=O,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20120208817A1,Brc1ccc(-c2ccccc2)cc1.Cc1cccc(CC(=O)c2ccccc2)c1>>O=C(Cc1ccccc1)c1ccc(-c2ccccc2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20110086854A1,CC(C)(C)CC1CNC(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.O=S(=O)(Cl)c1ccc(N2CCOCC2)nc1>>CC(C)(C)CC1CN(S(=O)(=O)c2ccc(N3CCOCC3)nc2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100063068A1,CNC(=O)c1c(-c2ccc(F)cc2)nn2ccc(OS(=O)(=O)C(F)(F)F)cc12.O=C(O)c1cccc(B(O)O)c1>>CNC(=O)c1c(-c2ccc(F)cc2)nn2ccc(-c3cccc(C(=O)O)c3)cc12,,O,,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US20090131458A1,CCC(C)COc1nc(N)c2ncn(C3CCCCO3)c2n1.O=C1CCC(=O)N1Br>>CCC(C)COc1nc(N)c2nc(Br)n(C3CCCCO3)c2n1,,ClC(Cl)Cl,,ClCCl,,val
US06376535B2,CCOC(=O)C=C1CCC(C#N)(c2ccc(OC)c3c2OCCO3)CC1>>COc1ccc(C2(C#N)CCC(=CC(=O)O)CC2)c2c1OCCO2,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20070185079A1,Cc1cc(N[C@H]2CC[C@H](N)C2)nc2ccc(F)cc12.Cn1cc(C=O)c2cccnc21>>Cc1cc(N[C@H]2CC[C@H](NCc3cn(C)c4ncccc34)C2)nc2ccc(F)cc12,,CO,,Cl,[Na+].[OH-],val
US20030069284A1,COC(=O)c1ccc(NC(=O)Oc2ccc([N+](=O)[O-])cc2)c(OC)c1.Cc1cnc(N)cn1>>COC(=O)c1ccc(NC(=O)Nc2cnc(C)cn2)c(OC)c1,,CN1CCCC1=O,,CCOC(C)=O,,val
US06528543B1,CCOC(=O)CCNC(=O)NC(=O)C(CC1CCCC1)c1ccc(Cl)c(Cl)c1>>O=C(O)CCNC(=O)NC(=O)C(CC1CCCC1)c1ccc(Cl)c(Cl)c1,,CCO,O,[K+].[OH-],,val
US06531613B1,CCCCC(CC)CBr.O=C1c2ccccc2-c2cc(O)cc3cccc1c23>>CCCCC(CC)COc1cc2c3c(cccc3c1)C(=O)c1ccccc1-2,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050277619A1,CC(=O)OCc1nc2c(Cl)ncnc2n1CC(C)(C)C>>CC(C)(C)Cn1c(CO)nc2c(Cl)ncnc21,,C1CCOC1,O,[Na+].[OH-],,val
US20120142672A1,ClCCCBr.O=C(O)Cc1ccc(F)cc1>>O=C(O)C(CCCCl)c1ccc(F)cc1,,C1CCOC1,,[Li]CCCC,,val
US20100113774A1,COC(=O)Cn1c(=O)c2ccccc2n(CC(=O)Nc2cc(Cl)c(OC)cc2OC)c1=O>>COc1cc(OC)c(NC(=O)Cn2c(=O)n(CC(=O)O)c(=O)c3ccccc32)cc1Cl,,CO,O,[K+].[OH-],,val
US20140213578A1,N#Cc1ccc(S(=O)(=O)Cl)cc1.NCCC=C1c2ccccc2CCc2ccccc21>>N#Cc1ccc(S(=O)(=O)NCCC=C2c3ccccc3CCc3ccccc32)cc1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20040171641A1,CC(C)CC(CS(=O)(=O)N1CCN(c2ccc(F)cc2)CC1)C(=O)OCc1ccccc1>>CC(C)CC(CS(=O)(=O)N1CCN(c2ccc(F)cc2)CC1)C(=O)O,[Pd],CO,,,,val
US20040152741A1,CC(C)(C)OC(=O)N[C@@H](C(=O)O)c1ccccc1.Cc1ccc(N)cc1C>>Cc1ccc(NC(=O)[C@H](NC(=O)OC(C)(C)C)c2ccccc2)cc1C,,C1CCOC1,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20090099175A1,CCc1cc([N+](=O)[O-])c(C(C)=O)cc1OC>>CCc1cc(N)c(C(C)=O)cc1OC,[Fe],CC(=O)O,O,N,,val
US05254558,CC(C)C(NC(=O)Cn1c(-c2ccccc2)ncc(NC(=O)OCc2ccccc2)c1=O)C(O[Si](C)(C)C(C)(C)C)C(F)(F)F>>CC(C)C(NC(=O)Cn1c(-c2ccccc2)ncc(N)c1=O)C(O[Si](C)(C)C(C)(C)C)C(F)(F)F,[Pd],C1CCOC1,CCO,,,val
US04609659,NCC(O)CO.O=[N+]([O-])c1nccnc1Cl>>O=[N+]([O-])c1nccnc1NCC(O)CO,,CC(C)O,,CCN(CC)CC,,val
US20130303505A1,COc1cc(C(C)(C)c2cnc(S)n2-c2ccc(F)cc2)ccc1Cl.Fc1cc(Br)cc(F)c1CBr>>COc1cc(C(C)(C)c2cnc(SCc3c(F)cc(Br)cc3F)n2-c2ccc(F)cc2)ccc1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110028486A1,Cc1cc(C#N)ccc1N.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(C#N)ccc1NC(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,Cl,val
US20090029963A1,C1CCN(C2CCNCC2)C1.Cc1c(C(=O)O)c(-c2ccncc2)nn1-c1cccc(OC(F)(F)F)c1>>Cc1c(C(=O)N2CCC(N3CCCC3)CC2)c(-c2ccncc2)nn1-c1cccc(OC(F)(F)F)c1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150031673A1,BrCc1ccccc1.Oc1ccc(Nc2ccccc2)cc1>>c1ccc(COc2ccc(Nc3ccccc3)cc2)cc1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05328641,CCCCCCCCCC(=O)Oc1ccc(C(=O)O)c(F)c1.CCCCCCCCOc1ccc(-c2ccc(C(=O)Oc3ccc(C(=O)OC(CCCCCC)C(F)(F)F)c(F)c3)cc2)cc1>>CCCCCCCCC(OC(=O)c1ccc(O)cc1)C(F)(F)F,,C1CCOC1,,,,val
US20150087646A1,COC(=O)c1ccc(-c2nn(-c3c(Cl)cccc3Cl)c(=O)[nH]2)cc1OC.Nc1ccc(F)c(C(F)(F)F)c1>>COc1cc(-c2nn(-c3c(Cl)cccc3Cl)c(=O)[nH]2)ccc1C(=O)Nc1ccc(F)c(C(F)(F)F)c1,,Cc1ccccc1,,C[Al](C)C,,val
US20040014780A1,BrCc1ccccc1.CCn1c(Cn2ccnc2-c2ncccn2)nc2cnccc21>>CCn1c(Cn2ccnc2-c2ncccn2)nc2c1CCN(Cc1ccccc1)C2,,CC(C)=O,,,,val
US05968985,COC(=O)c1cc(B(O)O)cc(C(=O)OC)c1.Clc1cc(Br)c(Cl)s1>>COC(=O)c1cc(C(=O)OC)cc(-c2cc(Cl)sc2Cl)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,[Cl-].[Na+],O=C([O-])[O-].[Li+],val
US20080153812A1,CC(C)(C)OC(=O)n1nc(CCc2ccc3c(c2)OCO3)cc1N.CN1CCN(c2ccc(C(=O)Cl)cc2)CC1>>CN1CCN(c2ccc(C(=O)Nc3cc(CCc4ccc5c(c4)OCO5)n[nH]3)cc2)CC1,,c1ccncc1,,O=C(O)C(F)(F)F,,val
US20090118500A1,CC(=O)c1csc(-c2ccc(Br)cc2)c1O.NNC(=O)c1ccc(C(=O)NCc2ccco2)s1>>CC(=NNC(=O)c1ccc(C(=O)NCc2ccco2)s1)c1csc(-c2ccc(Br)cc2)c1O,,CC(C)O,,,,val
US20020103226A1,CSc1ccc(C=O)cc1.c1cscn1>>CSc1ccc(C(O)c2nccs2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20150376194A1,CS(=O)(=O)N(c1ccc(C(=O)N2C[C@@H]3CN(C(=O)OCc4cc(Cl)cc(Cl)c4)C[C@@H]3C2)nc1)S(C)(=O)=O>>CS(=O)(=O)Nc1ccc(C(=O)N2C[C@@H]3CN(C(=O)OCc4cc(Cl)cc(Cl)c4)C[C@@H]3C2)nc1,,C1CCOC1,,[Na+].[OH-],,val
US20140221338A1,CCOC(=O)C(=CN(C)C)C(C)=O.CCOC(=O)c1cnn(-c2cccc(Cl)c2F)c1C.NNc1cccc(Cl)c1F>>CCOC(=O)c1cnn(-c2cccc(Cl)c2F)c1C.Cc1c(C(=O)O)cnn1-c1cccc(Cl)c1F,,CCO,,Cl,,val
US20090036536A1,CCOC(=O)c1ccc(-c2ccc(CC(O)CO)c(-c3ccc4c(c3)C(C)(C)CCC4(C)C)c2)cc1>>CC1(C)CCC(C)(C)c2cc(-c3cc(-c4ccc(C(=O)O)cc4)ccc3CC(O)CO)ccc21,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20060100229A1,CCCn1nc(C(N)=O)cc1CC>>CCCn1nc(C#N)cc1CC,,O=P(Cl)(Cl)Cl,,,,val
US05885986,CCCNCCC.CN1Cc2c(-c3nc(CCl)cs3)ncn2-c2ccc(F)c(Cl)c2C1=O>>CCCN(CCC)Cc1csc(-c2ncn3c2CN(C)C(=O)c2c-3ccc(F)c2Cl)n1,,C1CCOC1,,,,val
US20080146570A1,Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1N.Clc1cc(NC2CC2)nc(-c2cccnc2)n1>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1cc(NC2CC2)nc(-c2cccnc2)n1,,CN1CCCC1=O,,,,val
US20080114005A1,CCCc1nn(C)c2c(=O)n(CCNc3ccc(OC(C)(C)C(=O)OCC)cc3)c(C)nc12>>CCCc1nn(C)c2c(=O)n(CCNc3ccc(OC(C)(C)C(=O)O)cc3)c(C)nc12,,CO,O,O=C([O-])[O-].[Na+].[Na+],,val
US20130109661A1,C[C@@H]1CCCN1.Nc1cccc(F)n1>>C[C@@H]1CCCN1c1cccc(N)n1,,O,,,,val
US05102880,CCc1nc2c(C)cc(C#N)nc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1.C[Sn](C)(C)N=[N+]=[N-]>>CCc1nc2c(C)cc(-c3nnn[nH]3)nc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,CN(C)C=O,,Cc1ccccc1,,val
US04081545,CCOC(=O)c1cnc2ccnn2c1O>>O=C(O)c1cnc2ccnn2c1O,,CC(=O)O,,[Na+].[OH-],,val
US20060035951A1,Cc1cccc(-c2cc(NC(=O)c3ccc4c(c3)ncn4-c3cccc(F)c3)n(C(C)(C)C)n2)c1>>Cc1cccc(-c2cc(NC(=O)c3ccc4c(c3)ncn4-c3cccc(F)c3)[nH]n2)c1,,O=CO,,,,val
US04081530,COC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C.NN>>CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)NN,,CO,,O,,val
US20080300282A1,CCc1ccc(C(O)COc2ccc(C=O)cc2)nc1.Cc1ccc(S(=O)(=O)Cl)cc1>>CCc1ccc(C(COc2ccc(C=O)cc2)S(=O)(=O)c2ccc(C)cc2)nc1,,ClCCl,O,CCN(CC)CC,,val
US20050026973A1,CON=C(c1ccccc1)c1ccc2c(c1)sc(=O)n2CCOc1ccc(CC(OCC(F)(F)F)C(=O)O)cc1>>CO/N=C(/c1ccccc1)c1ccc2c(c1)sc(=O)n2CCOc1ccc(CC(OCC(F)(F)F)C(=O)O)cc1,,CCOCC,,,,val
US20120196884A1,CC(C)(C)OCCCN(c1ccc(NC(=O)Nc2ccccc2)cc1)S(=O)(=O)c1ccc(-c2ccccn2)s1>>O=C(Nc1ccccc1)Nc1ccc(N(CCCO)S(=O)(=O)c2ccc(-c3ccccn3)s2)cc1,,CO,ClCCl,O=C(O)C(F)(F)F,,val
US20140128612A1,COc1ccc(N)cc1.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>COc1ccc(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1,,ClCCl,,,,val
US20080176830A1,CI.COc1ccc(CN2C(=O)NCc3cc(-c4ccc(C(F)(F)F)cc4)ccc32)cc1>>COc1ccc(CN2C(=O)N(C)Cc3cc(-c4ccc(C(F)(F)F)cc4)ccc32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US05298649,CCOP(=O)(CC(=O)N1CCCCC1)OCC.CCc1cccc2c(C=O)cc(OC)c(OCOC)c12>>CCc1cccc2c(/C=C/C(=O)N3CCCCC3)cc(OC)c(O)c12,,CN(C)C=O,,O,[H-].[Na+],val
US20120245176A1,Cc1onc(-c2ccccc2Cl)c1C(=O)N1CCN(C(=O)OC(C)(C)C)CC1>>Cc1onc(-c2ccccc2Cl)c1C(=O)N1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080004267A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)CBr.NC(=O)c1cccs1>>Br.N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1coc(-c2cccs2)n1,,CC#N,,CCOCC,,val
US05789599,COC(=O)[C@@H]1[C@H](c2ccccc2)N1S(=O)c1ccc(C)cc1.O=C(O)C(F)(F)F>>COC(=O)[C@@H](N)[C@@H](O)c1ccccc1,,CC#N,,,,val
US20060040972A1,NN.O=C(Cc1ccccc1[N+](=O)[O-])c1c(O)c2cccnc2n(-c2ccccc2)c1=O>>O=c1c2c(Cc3ccccc3[N+](=O)[O-])n[nH]c2c2cccnc2n1-c1ccccc1,,CN(C)C=O,,O,,val
US20090275753A1,CC1=C2OC(C)(C)CC2C(COS(C)(=O)=O)C([N+](=O)[O-])=C1C.c1ccc(-c2ccn(C3CCNCC3)n2)cc1>>CC1=C2OC(C)(C)CC2C(CN2CCC(n3ccc(-c4ccccc4)n3)CC2)C([N+](=O)[O-])=C1C,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20130252941A1,Cc1cc(Nc2ncc(F)c3nn(-c4c(Cl)cc(C=O)cc4C#N)cc23)ncn1>>Cc1cc(Nc2ncc(F)c3nn(-c4c(Cl)cc(CO)cc4C#N)cc23)ncn1,,C1CCOC1,CCO,[BH4-].[Na+],,val
US20150191450A1,COC(=O)c1cccc2cnccc12.O=C(OO)c1cccc(Cl)c1>>COC(=O)c1cccc2c[n+]([O-])ccc12,,ClCCl,,O=C([O-])O.[Na+],,val
US20080018238A1,O=C(OO)c1cccc(Cl)c1.c1ccc(-n2c(-c3ccc(N4c5ccccc5Sc5ccccc54)cc3)nc3ccccc32)cc1>>O=S1(=O)c2ccccc2N(c2ccc(-c3nc4ccccc4n3-c3ccccc3)cc2)c2ccccc21,,ClCCl,,[K+].[OH-],,val
US04873255,C=CC(=O)OCC.Cc1cc(C)c2c(c1)OC(C)(COc1ccc(N)cc1)CC2=O.Cl>>CCOC(=O)C(Cl)Cc1ccc(OCC2(C)CC(=O)c3c(C)cc(C)cc3O2)cc1,,CC(C)=O,O,O=N[O-].[Na+],,val
US04307234,CC1(CN)OCCc2c1[nH]c1ccccc21.O=C(Cl)C1CCCCC1>>CC1(CNC(=O)C2CCCCC2)OCCc2c1[nH]c1ccccc21,,C1CCOC1,,CCN(CC)CC,,val
US05446121,CC(C)(c1ccccc1)n1nnc(-c2ccccc2-c2ccc(C=O)cc2)n1>>CC(C)(c1ccccc1)n1nnc(-c2ccccc2-c2ccc(CO)cc2)n1,,CCO,,O,[BH4-].[Na+],val
US04844835,CCOC(=O)c1ccc(-c2ccc(OCCCCCCCCCCOC(C)=O)cc2)cc1>>O=C(O)c1ccc(-c2ccc(OCCCCCCCCCCO)cc2)cc1,,O,,CCO,[Na+].[OH-],val
US04371737,CCOC(=O)c1c(CBr)[nH]c(=O)n1C(C)=O.COc1ccccc1N1CCNCC1.Cl>>CCOC(=O)c1[nH]c(=O)[nH]c1CN1CCN(c2ccccc2OC)CC1.Cl,,CCO,,CCN(CC)CC,,val
US20110021496A1,O=Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1.OC1CN(C2CCNCC2)C1>>OC1CN(C2CCN(Cc3cc4nc(Cl)nc(N5CCOCC5)c4s3)CC2)C1,,C1CCOC1,ClCCCl,O=C(O)C(F)(F)F,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150218085A1,N.O=C1CC(c2cc(Cl)ccc2[N+](=O)[O-])CC(=O)O1>>NC(=O)CC(CC(=O)O)c1cc(Cl)ccc1[N+](=O)[O-],,C1CCOC1,CO,,,val
US20040127574A1,CC(=Cc1ccc(F)cc1)[N+](=O)[O-].CCOC(=O)CC(=O)C(C)C>>CCOC(=O)c1c(C(C)C)oc(C)c1-c1ccc(F)cc1,,CCO,,C1CCNCC1,,val
US20150119405A1,COC(=O)C1C[C@H](NC(=O)OC(C)(C)C)[C@H](Nc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)ccc3n2)C1>>COc1cc(OC)c(Cl)c(-c2ccc3nc(N[C@@H]4CC(C(=O)O)C[C@@H]4NC(=O)OC(C)(C)C)ncc3c2)c1Cl,,CO,,C1CCOC1,[Na+].[OH-],val
US20030082404A1,Brc1ccc2cc3cc4ccc5c(ccc6cc7cc8ccccc8cc7c(Br)c65)c4cc3cc2c1.Cc1ccccc1C.OB(O)c1ccccc1>>c1ccc(-c2ccc3cc4cc5ccc6c(ccc7cc8cc9ccccc9cc8c(-c8ccccc8)c76)c5cc4cc3c2)cc1,,Cc1ccccc1C,,,,val
US06083943,CC(C)(C)OC(=O)N[C@H]1[C@H](COCc2ccccc2)[C@@H](CI)N(C(=O)OCc2ccccc2)[C@H]1c1ccccc1>>C[C@@H]1[C@H](COCc2ccccc2)[C@H](NC(=O)OC(C)(C)C)[C@H](c2ccccc2)N1C(=O)OCc1ccccc1,[Pd],CCO,CCOC(C)=O,CCN(CC)CC,,val
US20090076074A1,CCn1cc(NC(=O)Cc2ccc(O)cc2OC)cn1.Fc1ccc2nccc(Cl)c2c1>>CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4ccc(F)cc34)cc2OC)cn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04385177,NOc1ccccc1.O=C(Cl)CCl>>O=C(CCl)NOc1ccccc1,,CS(C)=O,,CCO,Cl,val
US20060189629A1,O=[N+]([O-])c1ccc(F)cc1.OCCOc1ccccn1>>O=[N+]([O-])c1ccc(OCCOc2ccccn2)cc1,,CN(C)C=O,,[H][H],[H-].[Na+],val
US20150232472A1,COC(=O)c1nc2ccc(Cl)nn2c1C>>Cc1c(C(=O)O)nc2ccc(Cl)nn12,,C1CCOC1,O,[Li+].[OH-],,val
US20150197511A1,Nc1cc(N)cc(C(F)(F)F)c1.O=C(O)CCCCl>>Nc1cc(NC(=O)CCCCl)cc(C(F)(F)F)c1,,ClCCl,,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US20010044538A1,CCCC[Si](CCCC)(CCCC)Oc1cccnc1C(=O)OCC.Fc1ccc([Mg]Cl)cc1>>CCCC[Si](CCCC)(CCCC)Oc1cccnc1C(=O)c1ccc(F)cc1,,C1CCOC1,,,,val
US20140135338A1,CCOC(=O)CCNC(=O)c1ccc(C(CCC(F)(F)F)Nc2cnc3ccccc3c2)cc1>>O=C(O)CCNC(=O)c1ccc(C(CCC(F)(F)F)Nc2cnc3ccccc3c2)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20100087431A1,CC(=O)COc1ccc(F)cc1Br.C[Mg]Cl>>CC(C)(O)COc1ccc(F)cc1Br,,C1CCOC1,,,,val
US20020151535A1,CC(C)(C)OC(=O)ON=C(C#N)c1ccccc1.NCc1noc([C@H](CCCC2CCCCC2)CC(=O)O)n1>>CC(C)(C)OC(=O)NCc1noc([C@H](CCCC2CCCCC2)CC(=O)O)n1,,C1COCCO1,O,CCN(CC)CC,,val
US20040198778A1,FC(F)(F)CCI.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>FC(F)(F)CC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[I-],,Cc1ccccc1,,,,val
US20120214803A1,COc1ccnc2c(NS(=O)(=O)c3ccccc3N)cccc12>>COc1ccnc2c3c(ccc12)-c1ccccc1S(=O)(=O)N3,,C1CCOC1,CC(=O)O,CC(C)(C)ON=O,,val
US20090042917A1,CCC(C)c1c(Br)nc(S(C)(=O)=O)nc1NCC(F)(F)F.c1cn[nH]c1>>CCC(C)c1c(Br)nc(-n2cccn2)nc1NCC(F)(F)F,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150166549A1,BrP(Br)Br.CC(O)c1oc(=O)c2ccccc2c1-c1cncs1>>CC(Br)c1oc(=O)c2ccccc2c1-c1cncs1,,CC#N,ClCCl,,,val
US20060223814A1,CN(C)CCCNC(=O)C=CC(Cc1ccccc1)NC(=O)OC(C)(C)C>>CN(C)CCCNC(=O)C=CC(N)Cc1ccccc1,,C1COCCO1,,Cl,,val
US20130109682A1,O=C1C[C@H](c2ccncc2[N+](=O)[O-])O[C@H](C2CC2)[C@H]1O>>O=[N+]([O-])c1cnccc1[C@H]1C[C@@H](O)[C@H](O)[C@@H](C2CC2)O1,,CCO,,[BH4-].[Na+],,val
US20110136805A1,COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1O[C@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1.Cl.ClCCl>>COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1O[C@@H]1CC[C@H](N)CC1.Cl.Cl,,ClCCl,,,,val
US20150291655A1,C=C(C)[C@@H]1CC[C@]2(C=O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(OS(=O)(=O)C(F)(F)F)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CC1(C)OB(C2=CC[C@](CF)(C(=O)OCc3ccccc3)CC2)OC1(C)C>>C=C(C)[C@@H]1CC[C@]2(C=O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@](CF)(C(=O)OCc7ccccc7)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20150299178A1,Br[Mg]C1CC1.CON(C)C(=O)C(C)(C)c1nc(-c2ccc(Cl)cc2)cs1>>CC(C)(C(=O)C1CC1)c1nc(-c2ccc(Cl)cc2)cs1,,C1CCOC1,,,,val
US04966904,BrB(Br)Br.COc1cc(F)c(C2CNCc3c2ccc(OC)c3OC)cc1OC>>Br.Oc1cc(F)c(C2CNCc3c2ccc(O)c3O)cc1O,,ClCCl,,CO,,val
US04910341,O=C1CO[CH-]N1c1ccc(NCCO)c([N+](=O)[O-])c1>>O=[N+]([O-])c1cc(NCCO)ccc1NCCO,,CCO,,[Na+].[OH-],,val
US04371644,CC(C)(c1ccc(OCC2CO2)cc1)c1ccc(OCC2CO2)cc1.CC1(C)CC2(CC(C)(C)N1)OCC(CO)O2.CCCCO.CCN(CC)CC.CCO.CCOC(C)=O>>CC(C)(c1ccc(OCC(O)CN2C(C)(C)CC3(CC2(C)C)OCC(CO)O3)cc1)c1ccc(OCC(O)CN2C(C)(C)CC3(CC2(C)C)OCC(CO)O3)cc1,,CCN(CC)CC,,,,val
US04740561,C=C(C)c1ccccc1.O=C1C=CC(=O)O1>>C=Cc1ccccc1.O=C1C=CC(=O)O1,,CCC(C)=O,,CCOCC,,val
US06429229B1,CCC(=O)C(=O)O.NCCCC[C@H](N)C(=O)O>>CCC(=O)C(=O)O.NCCCC[C@H](N)C(=O)O,,CO,,CC(C)=O,,val
US20090246137A1,Cc1cnc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)cc1-c1cccc(C(=O)OC(C)(C)C)c1>>Cc1cnc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)cc1-c1cccc(C(=O)O)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05422038,CC(=O)OC(C)=O.Cc1ccccc1.c1ccncc1>>CC(=O)OC(C)Cc1ccc2ccccc2c1,CN(C)c1ccncc1,c1ccncc1,,Cl,,val
US04642355,CCCCCCCSC[C@H](N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O)C(=O)OCC>>CCCCCCCSC[C@H](N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O)C(=O)O,,CCO,,[Na+].[OH-],,val
US20110105470A1,O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2.O=C1C=Cc2ccccc2C1=O>>O=C1C=C(N2CCC3(CC2)CSC2=C(O3)c3ccccc3C(=O)C2=O)c2ccccc2C1=O,,ClCCl,,CCN(CC)CC,,val
US20090221645A1,CCC(=O)Cl.Fc1ccc2ccccc2c1>>CCC(=O)c1cccc2ccc(F)cc12,,CCOC(C)=O,ClCCl,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20150218096A1,COC(=O)c1cnc2c(I)n[nH]c2c1.O=C(Cl)c1c(Cl)cccc1C(F)(F)F>>COC(=O)c1cnc2c(I)nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,N#N,val
US20060223850A1,CSc1ccc(-c2sc(C(C)=O)nc2-c2cccc(-c3cc(C(C)(C)S(C)(=O)=O)cc4cccnc34)c2)cc1.Clc1ccc([Mg]Br)cc1>>CSc1ccc(-c2sc(C(C)(O)c3ccc(Cl)cc3)nc2-c2cccc(-c3cc(C(C)(C)S(C)(=O)=O)cc4cccnc34)c2)cc1,,CO,,ClCCl,,val
US20160176849A1,CCOC(=O)c1ccc(-c2ccnc(Cl)n2)cc1.Nc1ccc(N2CCC(N3CC4CC(C3)O4)CC2)cc1>>CCOC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCC(N5CC6CC(C5)O6)CC4)cc3)n2)cc1,,CC(=O)N(C)C,O,c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1,O=C([O-])[O-].[Cs+].[Cs+],val
US20050154042A1,COC(=O)C[C@H]1C[C@H](C=Cc2c(-c3ccc(F)cc3)c(-c3ccc(F)cc3)c(C(=O)OCc3ccccc3)n2C(C)C)OC(C)(C)O1>>COC(=O)C[C@H]1C[C@@H](CCc2c(-c3ccc(F)cc3)c(-c3ccc(F)cc3)cn2C(C)C)OC(C)(C)O1,[Pd],C1CCOC1,CCO,,,val
US20160058734A1,CC/C(=C\c1ccc(C(=O)OC(C)(C)C)s1)C(=O)OC>>CC/C(=C\c1ccc(C(=O)OC(C)(C)C)s1)C(=O)O,,C1CCOC1,,CO,[Li+].[OH-],val
US05977111,NO.O=C1CC(CCCN2CCN(c3ccc(F)cc3)CC2)S(=O)(=O)c2ccccc21>>O=S1(=O)c2ccccc2C(=NO)CC1CCCN1CCN(c2ccc(F)cc2)CC1,,CO,,Cl,CC(=O)[O-].[Na+],val
US20150080364A1,CCOC(=O)c1cc(C)nn1C(C)C>>Cc1cc(CO)n(C(C)C)n1,,C1CCOC1,,[BH4-].[Li+],,val
US20100105744A1,CSCc1cccc2cc[nH]c12.OC(c1ccc(Cl)cc1)C1CC1>>CSCc1cccc2c(C(c3ccc(Cl)cc3)C3CC3)c[nH]c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US06162799,CCOCCl.C[Si](C)(C)CCCCCCCCCC1=C(O)C(=O)c2ccccc2C1=O>>CCOCOC1=C(CCCCCCCCC[Si](C)(C)C)C(=O)c2ccccc2C1=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070021450A1,CC(C)CCON=O.CCN(C)C(=O)Oc1ccc2c(c1)C(Nc1cc(=O)[nH]c(=O)[nH]1)CC2>>CCN(C)C(=O)Oc1ccc2c(c1)C(Nc1[nH]c(=O)[nH]c(=O)c1N=O)CC2,Cl,CCO,,,,val
US20100069381A1,Nc1cc(-c2nnc(SCc3cccc(F)c3)o2)ccn1.O=C(Cl)CCc1ccccc1>>O=C(CCc1ccccc1)Nc1cc(-c2nnc(SCc3cccc(F)c3)o2)ccn1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20140256677A1,BrBr.c1ccc(-c2cc3n(n2)CCCO3)cc1>>Brc1c(-c2ccccc2)nn2c1OCCC2,,ClC(Cl)Cl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US04465507,CCOC(=O)C(C)Oc1ccc(Cl)c(C)c1Cl>>Cc1c(Cl)ccc(OC(C)C(=O)O)c1Cl,,CC(=O)O,,Cl,,val
US20090176769A1,CC(C)(C)CCN.CC(C)(C)N1CCN(c2c(F)cc(F)cc2C=O)CC1.O=C(O)C[C@H](S)C(=O)O>>CC(C)(C)CCN1C(=O)[C@H](CC(=O)O)SC1c1cc(F)cc(F)c1N1CCN(C(C)(C)C)CC1,,Cc1ccccc1,,,,val
US20110118230A1,Cn1cc(-c2cnc3c(c2)c2c(O)c(C#N)ncc2n3S(=O)(=O)c2ccccc2)cn1.O=S(=O)(OS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>Cn1cc(-c2cnc3c(c2)c2c(OS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c(C#N)ncc2n3S(=O)(=O)c2ccccc2)cn1,,ClCCl,,Cl,c1ccncc1,val
US04316839,CCOC(=O)C(C(=O)OCC)=C1CN(C)C(=O)c2ccccc2N1>>CCOC(=O)C=C1CN(C)C(=O)c2ccccc2N1,,CCO,,[Na+].[OH-],,val
US20040110945A1,COC(=O)Cc1ccc2nc(Nc3cccc(F)c3C)oc2c1F>>Cc1c(F)cccc1Nc1nc2ccc(CC(=O)O)c(F)c2o1,,C1CCOC1,CO,[Na+].[OH-],,val
US20080306068A1,Cn1nc(C(C)(C)C)cc1NC(=O)Nc1cccc(OC2CCN(OCc3ccccc3)C(=C=O)C2)c1>>Cn1nc(C(C)(C)C)cc1NC(=O)Nc1cccc(OC2CCNCC2)c1,[Pd],CCO,,,,val
US20100216860A1,CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)=O)cccc32)c1>>CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1,,CO,,Cl,[BH4-].[Na+],val
US20090291983A1,CCOC(=O)C1c2ccccc2C(=O)N1Cc1ccccc1OC>>COc1ccccc1CN1C(=O)c2ccccc2C1C(=O)O,,CO,,Cl,,val
US20090186886A1,CN(C)CCN.[O-][n+]1nc(Cl)nc2cc3c(cc21)OCO3>>CN(C)CCNc1nc2cc3c(cc2[n+]([O-])n1)OCO3,,COCCOC,,,,val
US20090312310A1,COC(=O)C1=C(C(C)C)N2C(=N[C@@](C)(c3ccc(Cl)c([N+](=O)[O-])c3)[C@H]2c2ccc(Cl)cc2)S1>>COC(=O)C1=C(C(C)C)N2C(=N[C@@](C)(c3ccc(Cl)c(N)c3)[C@H]2c2ccc(Cl)cc2)S1,[Fe],CCO,,CC(=O)O,,val
US20110065682A1,CNC(=O)c1ccc(-c2ccc(-c3nn(C)c(C(=O)Nc4cc5c(cc4NCc4ccc(OC)cc4OC)CN(Cc4ccc(OC)cc4OC)C5)c3OCc3ccc(OC)cc3)cc2)cn1>>CNC(=O)c1ccc(-c2ccc(-c3nn(C)c(-c4nc5cc6c(cc5[nH]4)CNC6)c3O)cc2)cn1,,CC(=O)O,,,,val
US20120128592A1,CN(C)c1ccc(C(=O)c2ccc3cc(NC(=O)OC(C)(C)C)ccc3c2)cc1>>CN(C)c1ccc(C(=O)c2ccc3cc(N)ccc3c2)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20040019210A1,CCOC(=O)C1CCC(N2C(=O)N(c3c(F)c(OC)cc(OC)c3F)Cc3cnc(S(C)=O)nc32)CC1.CN>>CCOC(=O)C1CCC(N2C(=O)N(c3c(F)c(OC)cc(OC)c3F)Cc3cnc(NC)nc32)CC1,,C1COCCO1,,C1CCOC1,,val
US20070099990A1,COc1cccc(B(O)O)c1.Cc1c(Br)c2c(c(C)c1NC(=O)CC(C)(C)C)C(c1ccc(C(C)C)cc1)CO2>>COc1cccc(-c2c(C)c(NC(=O)CC(C)(C)C)c(C)c3c2OCC3c2ccc(C(C)C)cc2)c1,,CCCCCC,CCOC(C)=O,,,val
US20060148858A1,CCOC(=O)CP(=O)(OCC)OCC.Cc1nn(-c2ccc(C(F)(F)F)cn2)cc1COc1cc(C=O)n(C)n1>>CCOC(=O)/C=C/c1cc(OCc2cn(-c3ccc(C(F)(F)F)cn3)nc2C)nn1C,,O,,CN(C)C=O,[H-].[Na+],val
US20080051418A1,CCOC(=O)CCc1cc(OC(C)C)n[nH]1.Fc1cccc(Cl)c1CCl>>CCOC(=O)CCc1cc(OC(C)C)nn1Cc1c(F)cccc1Cl,,CN(C)C=O,,Cl,[H-].[Na+],val
US20090258886A1,C=CCNC.O=Cc1cccc([N+](=O)[O-])c1>>C=CCN(C)Cc1cccc([N+](=O)[O-])c1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120101083A1,Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(=O)CBr)CC2.NCCO>>Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(=O)CNCCO)CC2,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04876346,CCN=C=O.CNC[C@H](O)c1cccc(O)c1>>CCNC(=O)NC[C@H](O)c1cccc(O)c1,CCN(CC)CC,,,CCOCC,,val
US20140200222A1,CC(C)(C)OC(=O)N1CCC(O)(c2cc(Cl)ccn2)CC1.COCCN(CCOC)S(F)(F)F>>CC(C)(C)OC(=O)N1CCC(F)(c2cc(Cl)ccn2)CC1,,ClCCl,,,,val
US20060229236A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(OCc1ccccc1)C(=O)CCCCC[C@H](N)C(=O)O>>CC(OCc1ccccc1)C(=O)CCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)O,,C1COCCO1,,Cl,[Na+].[OH-],val
US20050032786A1,O=C(OO)c1cccc(Cl)c1.O=c1nc(-c2cccc(SCc3ccccc3)n2)sc2ccccc12>>O=c1nc(-c2cccc(S(=O)Cc3ccccc3)n2)sc2ccccc12,,ClC(Cl)Cl,,,,val
US07196104B2,CC(C)(C)OC(=O)N1CC=C(c2cccc(NC(=O)Nc3csc(-c4ccncc4)n3)n2)CC1>>O=C(Nc1cccc(C2=CCNCC2)n1)Nc1csc(-c2ccncc2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150087639A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc([N+](=O)[O-])ccc1F>>CC(C)(C)OC(=O)Nc1cc([N+](=O)[O-])ccc1F,CN(C)c1ccncc1,C1CCOC1,,,,val
US20140350002A1,C[C@@H](CCN=[N+]=[N-])c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C>>C[C@@H](CCN)c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C,[Pd],CCO,,,,val
US20080146547A1,COc1nnc(I)c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc12.OB(O)c1ccccc1>>COc1nnc(-c2ccccc2)c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,Cc1ccccc1,O,O=C([O-])[O-].[K+].[K+],val
US04289768,O.O=C(CCn1ccnc1)N1c2ccccc2Sc2ccc(Cl)cc21>>O=C(CCn1ccnc1)N1c2ccccc2S(=O)c2ccc(Cl)cc21,,ClCCl,,O=C([O-])O.[Na+],,val
US20070167443A1,CO.O=C(c1ccc(Cl)nc1)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O>>COc1ccc(C(=O)c2cn(Cc3cccc(Br)n3)c3ccccc3c2=O)cn1,,CO,,C[O-].[Na+],,val
US20040009970A1,COc1ccc2c(c1)C(=O)NCC(=O)N2>>COc1ccc2c(c1)CNCCN2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160184318A1,Clc1ccc(Br)c(CBr)c1.c1cn[nH]n1>>Clc1ccc(Br)c(Cn2nccn2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130090323A1,CC(C)(C)OC(=O)[C@H]1CCCN1.Cc1c(Cl)nc2cc(F)cc(F)c2c1Cl>>Cc1c(N2CCC[C@@H]2C(=O)OC(C)(C)C)nc2cc(F)cc(F)c2c1Cl,,CC#N,,CCN(CC)CC,,val
US20150259295A1,CCOC(=O)C1(c2ccc(-c3ccc(-c4cnn(C)c4NC(=O)OC(C)c4ccccc4Cl)cc3)cc2)CC1>>CC(OC(=O)Nc1c(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)cnn1C)c1ccccc1Cl,,C1CCOC1,,[Li+].[OH-],,val
US20030125371A1,CCOC(=O)C(=O)c1cn(Cc2ccccc2)c2c(-c3ccc(OC(F)(F)F)cc3)cccc12>>O=C(O)C(=O)c1cn(Cc2ccccc2)c2c(-c3ccc(OC(F)(F)F)cc3)cccc12,,C1CCOC1,O,[K+].[OH-],,val
US20050009907A1,COc1ccc(-c2ccc(C=O)c3sccc23)cc1>>O=Cc1ccc(-c2ccc(O)cc2)c2ccsc12,,ClCCl,,BrB(Br)Br,,val
US20050032873A1,BrC(Br)(Br)Br.OCCc1coc2ccccc12>>BrCCc1coc2ccccc12,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040092518A1,CCC(C=Cc1cccc(OCc2c(C)cccc2C)c1)C(=O)O>>Cc1cccc(C)c1COc1cccc(C=CCC(=O)O)c1,,CCO,,[Na+].[OH-],,val
US05486533,C=CCCl.CC(C)(C)c1ccc(O)cc1>>C=CCOc1ccc(C(C)(C)C)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050234238A1,CC(C)(c1cc(-c2cccc(-c3cccc(C=O)c3)c2)c2ncccc2c1)S(C)(=O)=O.COC(=O)CP(=O)(OC)OC>>CC(C)(c1cc(-c2cccc(-c3cccc(C=CC(=O)O)c3)c2)c2ncccc2c1)S(C)(=O)=O,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20130324530A1,CC(=O)N1CCC(CNc2cncc(-c3cc(N[C@@H]4CC[C@@H](NC(=O)OCc5ccccc5)CC4)ncc3Cl)c2)CC1>>CC(=O)N1CCC(CNc2cncc(-c3cc(N[C@@H]4CC[C@@H](N)CC4)ncc3Cl)c2)CC1,,CC#N,,C[Si](C)(C)I,,val
US20140221409A1,CNC1CCN(Cc2ccc(C(F)(F)F)cc2)CC1.CO.Cc1cc(C)nc(OCC(=O)N(C)C2CCN(Cc3ccc(C(F)(F)F)cc3)CC2)n1.Cc1cc(C)nc(OCC(=O)O)n1.O=C(O)/C=C\C(=O)O>>CC(C)O.CC(C)OC(C)C.Cc1cc(C)nc(OCC(=O)N(C)C2CCN(Cc3ccc(C(F)(F)F)cc3)CC2)n1,,CO,,,,val
US20160083655A1,C=C(C)C(=O)OC(=O)C(=C)C.N#C/C(=C\c1ccc(C(F)(F)F)cc1)c1ccc(OCCCCCCCCO)cc1>>C=C(C)C(=O)OCCCCCCCCOc1ccc(/C(C#N)=C/c2ccc(C(F)(F)F)cc2)cc1,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,O,val
US06063806,CCOC(=O)CCC1CN(C(C)=O)c2c(NC(=O)C(C)(C)C)c(C)cc(C)c21>>Cc1cc(C)c2c(c1NC(=O)C(C)(C)C)NCC2CCC(=O)O,,CCO,O,[K+].[OH-],,val
US20130079324A1,C[Si](C)(C)CCOCn1cc(F)c2c(Cl)nc(Cl)nc21.O=[N+]([O-])c1cccc(O)c1>>C[Si](C)(C)CCOCn1cc(F)c2c(Oc3cccc([N+](=O)[O-])c3)nc(Cl)nc21,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160159815A1,COC(=O)c1ccc(OCCC2CC2(F)F)c(OC)c1>>COc1cc(C(=O)O)ccc1OCCC1CC1(F)F,,CO,O,Cl,[Na+].[OH-],val
US05936123,COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)C)cc1C(C)C.O=S(=O)(O)O>>COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)C)cc1C(C)C.O=S(=O)(O)O,,CO,,CCOCC,,val
US05763437,NCC(=O)OCc1ccccc1.O=C(Cl)c1cccc([N+](=O)[O-])c1>>O=C(CNC(=O)c1cccc([N+](=O)[O-])c1)OCc1ccccc1,,ClCCl,,CCN(CC)CC,Cc1ccc(S(=O)(=O)O)cc1,val
US20140171408A1,CS(=O)(=O)c1ncnc2nc(-c3c(Cl)cccc3Cl)sc12.NC(=O)C1CC1>>O=C(Nc1ncnc2nc(-c3c(Cl)cccc3Cl)sc12)C1CC1,,CN(C)C=O,,[H-].[Na+],,val
US20100227880A1,CN1CCN(Cc2c(CN3C(=O)c4ccccc4C3=O)nc3ccccn23)CC1>>CN1CCN(Cc2c(CN)nc3ccccn23)CC1,,CO,,NN,,val
US20130261077A1,CC(=O)OC(C)=O.COC(=O)c1ccc(-c2cccc([C@@H]3O[C@@H](COC(C)=O)[C@H](CC(=O)[O-])[C@H](CC(=O)[O-])[C@H]3CC(=O)[O-])c2)nc1.[OH-]>>CC(=O)OC[C@H]1O[C@H](c2cccc(-c3ccc(C(=O)O)cn3)c2)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,CN(C)c1ccncc1,CO,,Cl,,val
US20130059835A1,CCOc1c(C(C)=O)cc(Cl)c(F)c1C1CNC(=O)C1.[C-]#N>>CCOc1c(C(C)=O)cc(Cl)c(C#N)c1C1CNC(=O)C1,,CS(C)=O,,O,,val
US20130045986A1,CC(C)OC(=O)Cl.Fc1cc(-n2cnnn2)ccc1-c1ccc2oc(C3CCNCC3)nc2c1>>CC(C)OC(=O)N1CCC(c2nc3cc(-c4ccc(-n5cnnn5)cc4F)ccc3o2)CC1,,ClCCl,O,Cc1ccccc1,O=C(O)C(F)(F)F,val
US20140080816A1,CC(C(N)=O)N1CCN(C2CC2)c2ccccc21>>CC(CN)N1CCN(C2CC2)c2ccccc21,,C1CCOC1,CCOC(C)=O,CO,Cl,val
US20130041007A1,CC(C)(C)OC(=O)n1c2c(c3cc(F)c(Cl)cc31)CCCC2=O>>O=C1CCCc2c1[nH]c1cc(Cl)c(F)cc21,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US04155913,NNC(=O)C(N)=O.S=C1CN=C(c2ccccc2Cl)c2cc(Cl)sc2N1>>NC(=O)c1nnc2n1-c1sc(Cl)cc1C(c1ccccc1Cl)=NC2,,CO,,,,val
US20040235839A1,CCC(N)CN1CC(C)(C)OCC1C(=O)Nc1cc(Cl)cc2c1[nH]c1cnccc12.Cc1ncccc1C(=O)O>>CCC(CN1CC(C)(C)OCC1C(=O)Nc1cc(Cl)cc2c1[nH]c1cnccc12)NC(=O)c1cccnc1C,,O,c1ccncc1,CCN=C=NCCCN(C)C,,val
US20100137394A1,COc1ccc(CC(=O)N2CCC(c3ccc([N+](=O)[O-])cc3)=N2)cc1OC>>COc1ccc(CC(=O)N2CCC(c3ccc(N)cc3)=N2)cc1OC,[Pd],CC#N,ClCCl,,,val
US20080139505A1,CC(C)[Si](Cl)(C(C)C)C(C)C.OCc1ccc(Br)cc1>>CC(C)[Si](OCc1ccc(Br)cc1)(C(C)C)C(C)C,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US20070149521A1,Clc1cnccn1.O=Cc1cccc(OCc2ccccc2)c1>>OC(c1cccc(OCc2ccccc2)c1)c1nccnc1Cl,,C1CCOC1,CCOC(C)=O,CC1(C)CCCC(C)(C)N1,[Li]CCCC,val
US20050143372A1,CC(C)(C)OC(=O)NC1CCNC1.COc1ccccc1Oc1cccc(C=O)c1>>COc1ccccc1Oc1cccc(CN2CCC(NC(=O)OC(C)(C)C)C2)c1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140350030A1,CC(C)(C)OC(=O)NC12CCCC(C=O)(CC1)C2.COP(=O)(OC)C(=[N+]=[N-])C(C)=O>>C#CC12CCCC(NC(=O)OC(C)(C)C)(CC1)C2,,CCOC(C)=O,CO,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20110144336A1,CC(=O)OC(C)=O.CC1NC(=O)CNC1=O>>CC(=O)N1CC(=O)N(C(C)=O)C(C)C1=O,,CC(=O)OC(C)=O,,,,val
US20160096827A1,COc1cc(Nc2ncnc(-c3ccc(F)c(C#N)c3)n2)ccc1N1CCN(C2COC2)CC1.O=C1CCC(O)CN1>>COc1cc(Nc2ncnc(-c3ccc(N4C[C@H](O)CCC4=O)c(C#N)c3)n2)ccc1N1CCN(C2COC2)CC1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20160096839A1,COc1cc(-c2cc(Cl)ccc2F)ncn1>>Oc1cc(-c2cc(Cl)ccc2F)ncn1,,CC(=O)O,,Br,,val
US20080300240A1,CCOC(=O)CBr.S=c1[nH]c2ccccc2[nH]1>>CCOC(=O)CSc1nc2ccccc2[nH]1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20100330199A1,CCCCOC(=O)c1nc(-c2ccccc2)c2c(CBr)nsc2c1OC(=O)C(C)(C)C.c1ccc2[nH]ccc2c1>>CCCCOC(=O)c1nc(-c2ccccc2)c2c(Cn3ccc4ccccc43)nsc2c1O,,CN(C)C=O,,O,[H-].[Na+],val
US04224325,Cc1cc(C)n(-c2ccc(Cl)nn2)n1.NNCCO>>Cc1cc(C)n(-c2ccc(NNCCO)nn2)n1,,CCO,,Cl,,val
US20110105463A1,CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)NC4CCC(C)(C)CC4)cc3)c(Cl)cc21>>CC1(C)CCC(NC(=O)c2ccc(Oc3cc4c(cc3Cl)C(C(=O)O)CCO4)cc2)CC1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20030139418A1,BrCc1ccccc1OCc1ccccc1.O=C(O)c1ccc(S)cc1>>O=C(O)c1ccc(SCc2ccccc2OCc2ccccc2)cc1,,CC(=O)O,CN(C)C=O,O,[H-].[Na+],val
US20110071150A1,Cn1nc(C(F)(F)F)cc1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cn1nc(C(F)(F)F)cc1OS(=O)(=O)C(F)(F)F,,ClCCl,,O,,val
US20150225404A1,CC1(C)OB(c2cncc(CO)c2)OC1(C)C.N#Cc1ccc(COc2cc(Cl)c3c(n2)CCC3)cc1>>N#Cc1ccc(COc2cc(-c3cncc(CO)c3)c3c(n2)CCC3)cc1,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US06207693B1,CCCBr.COC(=O)c1cccc2[nH]c(C)nc12>>CCCn1c(C)nc2c(C(=O)OC)cccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160068489A1,Cc1nc(N)c(C)c(C)c1OCc1ccccc1.O=C(Cl)c1cccc2ccccc12>>Cc1nc(NC(=O)c2cccc3ccccc23)c(C)c(C)c1OCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US04797391,CCC1(CCC(C)=O)C(=O)c2c(cc(OCC(=O)OC)c(Cl)c2Cl)C1C>>CCC12CCC(=O)C=C1c1c(cc(OCC(=O)O)c(Cl)c1Cl)C2C,,CC(=O)O,Cl,,,val
US20030092720A1,CC(C)c1csc(CO)n1.O=S(Cl)Cl>>CC(C)c1csc(CCl)n1,,ClCCl,,,,val
US05801170,Cc1noc(-c2ccc(Br)c(C)c2)n1.O=C(O)c1ccc(B(O)O)cc1>>Cc1noc(-c2ccc(-c3ccc(C(=O)O)cc3)c(C)c2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20100113441A1,Clc1ccc(-c2cc3nccn3c(Cl)n2)c(Cl)c1.Nc1nc(NCCO)ccc1[N+](=O)[O-]>>Nc1nc(NCCOc2nc(-c3ccc(Cl)cc3Cl)cc3nccn23)ccc1[N+](=O)[O-],,CN(C)C=O,O,CC(=O)O,[H-].[Na+],val
US20100004249A1,CC(C)(C)OC(=O)N1CCN2C(=O)N(c3ccccc3Cl)CC2C1.Cl>>Cl.O=C1N(c2ccccc2Cl)CC2CNCCN12,,CCOC(C)=O,Cl,,,val
US20120232068A1,CC(C)(C)OC(=O)Nc1cncc(Br)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(C)(C)OC(=O)Nc1cncc(B2OC(C)(C)C(C)(C)O2)c1,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20100305122A1,COC1CCC(C(=O)O)CC1>>COC1CCC(CO)CC1,,C1CCOC1,,,,val
US20090306066A1,C=O.C[C@@H]1CN(Cc2ccccc2)[C@H](C)CN1>>C[C@@H]1CN(Cc2ccccc2)[C@H](C)CN1C,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US06451805B1,Nc1c(N=O)c(-c2ccc(CO)o2)nn1Cc1ccccc1F>>Nc1c(-c2ccc(CO)o2)nn(Cc2ccccc2F)c1N,[Pd],CCO,,[H][H],,val
US20120040957A1,CCI.COc1ccc2ncc(OCCN3CCC(NC(=O)c4ccc5c(c4)NC(=O)CS5)CC3)c(O)c2n1>>CCOc1c(OCCN2CCC(NC(=O)c3ccc4c(c3)NC(=O)CS4)CC2)cnc2ccc(OC)nc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070099908A1,C[Si](C)(C)CC(O)CCc1ccc(S(=O)(=O)c2ccccc2)cc1Br>>C=CCCc1ccc(S(=O)(=O)c2ccccc2)cc1Br,,ClCCl,,CCOCC,FB(F)F,val
US20090253656A1,CCN(CC)CC(=O)OC1CCN(c2ccc(/C=C(\C#N)c3ccc(OC)c(OC)c3)s2)CC1.Cl>>CCN(CC)CC(=O)OC1CCN(c2ccc(/C=C(\C#N)c3ccc(OC)c(OC)c3)s2)CC1.Cl,,CC(C)O,,,,val
US20120264792A1,CC(=O)c1ccc(N)cc1.O=C(Cl)OCc1ccccc1>>CC(=O)c1ccc(NC(=O)OCc2ccccc2)cc1,,C1COCCO1,O,O=C([O-])O.[Na+],,val
US04544764,COc1cccc2c1CC(CC(=O)O)C1(C2)OCCO1>>COc1cccc2c1CC(CC(=O)O)C(=O)C2,,CC(C)=O,,Cl,,val
US04409214,C=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)C(=NOC)c3csc(NC=O)n3)[C@H]2SC1>>C=CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOC)c3csc(NC=O)n3)[C@H]2SC1,,ClCCl,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20060267243A1,CC(=O)OCC(COC(C)=O)OC(C)=O.CC(C)=O>>CC(=O)OCC(COC(C)=O)OC(C)=O.CC(C)=O,,CC(C)=O,,,,val
US04429146,O=C(COc1ccc(Cl)cc1Cl)OCCOCCOCCO.O=C(Cl)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-]>>O=C(COc1ccc(Cl)cc1Cl)OCCOCCOCCOC(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],,CCOCC,,C1CCOC1,CCN(CC)CC,val
US04002746,CCCC[C@]12CC[C@@H]3C4=C(CC[C@H]3[C@@H]1CC[C@@H]2O)CC(OC)=CC4>>CCCC[C@]12CC[C@@H]3[C@H]4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O,,CO,O,Cl,,val
US20140073627A1,CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.COc1cc(C)c(S(=O)(=O)N(C)Cc2nsc(C(=O)O)n2)c(C)c1.On1nnc2ccccc21>>COc1cc(C)c(S(=O)(=O)N(C)Cc2nsc(C(=O)NCCc3ccc(C4=NCCN4)cc3)n2)c(C)c1,,CN(C)C=O,,,,val
US20150274767A1,CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](c2ccc3c(N)ncnn23)O[C@]1(C=O)CO.COP(=O)(OC)C(=[N+]=[N-])C(C)=O>>C#C[C@]1(CO)O[C@@H](c2ccc3c(N)ncnn23)C[C@@H]1O[Si](C)(C)C(C)(C)C,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20060241147A1,Nc1ccc(Oc2ccc3c(c2)CCC(c2ccccc2)O3)nc1.O=C(O)CCC(=O)O>>O=C(O)CCC(=O)Nc1ccc(Oc2ccc3c(c2)CCC(c2ccccc2)O3)nc1,,ClCCl,,O,,val
US20140275015A1,O=C(O)c1cccc(C(F)(F)F)c1Cl.c1ccc(-n2cnc3c2CCNC3)nc1>>O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(ncn2-c2ccccn2)C1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05011683,CC/C=C/C(C)Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC/C=C/C(C)[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-],,CC#N,,,,val
US20150291572A1,CCOC(=O)c1ncc(OC(F)F)cc1Cl>>OCc1ncc(OC(F)F)cc1Cl,,CO,,[BH4-].[Na+],,val
US20150232459A1,CC(C)(C)OC(=O)N1C[C@H](COCc2ccccc2)O[C@H](C(=O)O)C1.CI>>COC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H](COCc2ccccc2)O1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20050090533A1,CN(C(=O)C(C)(C)c1cc(Cl)cc(Cl)c1)c1cnc(Cl)cc1-c1ccccc1Cl.NCCO>>CN(C(=O)C(C)(C)c1cc(Cl)cc(Cl)c1)c1cnc(NCCO)cc1-c1ccccc1Cl,,O=C([O-])O,[Na+],,,val
US20120302541A1,CC(C)(C)OC(=O)N1CCC[C@H]1C=O.COc1ccc(Oc2ccc(N)c(Oc3ccc(OC)cc3)c2)cc1>>COc1ccc(Oc2ccc(NC[C@@H]3CCCN3C(=O)OC(C)(C)C)c(Oc3ccc(OC)cc3)c2)cc1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140349987A1,CC(C)(C)c1cc(Br)cc(Br)c1.O=C1CCC1>>CC(C)(C)c1cc(Br)cc(C2(O)CCC2)c1,,C1CCOC1,,[Li]CCCC,,val
US05175166,CC(=O)O.O=S(Cl)Cl.OC1CN=C(C(F)(F)F)NC1>>CC(=O)OC1CN=C(C(F)(F)F)NC1.Cl,,CCO,,,,val
US20100125071A1,CCOc1c(Nc2ccc(Cl)c(S(C)(=O)=O)c2O)c(=O)c1=O.NC1CCSC1>>CS(=O)(=O)c1c(Cl)ccc(Nc2c(NC3CCSC3)c(=O)c2=O)c1O,,CCO,,,,val
US20120289493A1,O=c1[nH]ncc2ccc(Br)cc12.OB(O)c1ccc(OC(F)(F)F)cc1>>O=c1[nH]ncc2ccc(-c3ccc(OC(F)(F)F)cc3)cc12,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20080051395A1,CN(C)CCOc1cccc(N)c1.O=C(Nc1cccc(-c2nn3cccc(F)c3c2-c2ccnc(Cl)n2)c1)c1c(F)cccc1F>>CN(C)CCOc1cccc(Nc2nccc(-c3c(-c4cccc(NC(=O)c5c(F)cccc5F)c4)nn4cccc(F)c34)n2)c1,Cl,CC(C)O,,,,val
US06043254,Cn1cncc1-c1ccc([N+](=O)[O-])cc1>>Cn1cncc1-c1ccc(N)cc1,,CO,,,,val
US20080227724A1,CCCCCCCCCCCC(=O)Cl.N[C@H]1CCCNC(=O)C1>>CCCCCCCCCCCC(=O)N[C@H]1CCCNC(=O)C1,,ClCCl,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20150064242A1,CCCCC/C=C/CCC(=O)OCC>>CCCCC/C=C/CCCO,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060004021A1,O=Cc1nnn(-c2cccc(Cl)c2)n1>>OCc1nnn(-c2cccc(Cl)c2)n1,,C1CCOC1,,[BH4-].[Li+],,val
US20100105657A1,O=C1NCCOc2ccc([N+](=O)[O-])cc21>>O=[N+]([O-])c1ccc2c(c1)CNCCO2,,C1CCOC1,,Cl,,val
US20150266895A1,COc1ccc(CN2c3n[nH]c4cc(NC(=O)N[C@H](C)c5ccccc5)nc(c34)CC2C)cc1>>C[C@@H]1Cc2nc(NC(=O)N[C@H](C)c3ccccc3)cc3[nH]nc(c23)N1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20130217671A1,C[Si](C)(C)C#Cc1cncc([N+](=O)[O-])c1>>C#Cc1cncc([N+](=O)[O-])c1,,CCOC(C)=O,CO,O=C([O-])[O-].[K+].[K+],,val
US20040106616A1,N#Cc1ccc(Br)cc1[N+](=O)[O-]>>N#Cc1ccc(Br)cc1N,,Cl,,[Na+].[OH-],,val
US05455253,O=C1CCCC2=C1C(c1cccc(Br)c1)C1=C(CCCC1=O)N2>>O=C1CCCC2=C1C(c1cccc(Br)c1)C1=C(CCCC1)N2,,c1ccncc1,,CCO,[BH4-].[Na+],val
US05811419,Cn1nnnc1SCC(=O)O.O=C1CCC(=O)N1O>>CC(=O)ON1C(=O)CCC1=O,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100292222A1,CS(=O)(=O)Cl.OCCOc1ccc(N2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1>>CS(=O)(=O)OCCOc1ccc(N2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1,,ClCCl,,CCN(CC)CC,,val
US03976653,COc1ccc(C[C@H]2[C@@H](C(=O)O)CCCN2Cc2ccccc2)cc1.[Li]C>>COc1ccc(C[C@H]2[C@@H](C(C)=O)CCCN2Cc2ccccc2)cc1,,CCOCC,,,,val
US20080227797A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3ccc(F)c(F)c3)c2=O)CC1.Cl>>Cl.N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3ccc(F)c(F)c3)c2=O)CC1,,C1COCCO1,,,,val
US20100216786A1,CC(=O)N1CCN(c2ccc3nc(N)c(C#N)c(O)c3c2)CC1.O=P(Cl)(Cl)Cl>>CC(=O)N1CCN(c2ccc3nc(N)c(C#N)c(Cl)c3c2)CC1,,CC#N,,[Na+].[OH-],,val
US20150274777A1,COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)c2cc(C)on2)C(=O)N[C@@H](Cc2ccccc2)C(O)C(=O)NCc2ccccc2)cc1>>COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)c2cc(C)on2)C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCc2ccccc2)cc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US04999356,NC(=O)N[N+](=O)[O-].c1ccc(-n2nc(N3CCNCC3)c3ccccc32)cc1>>NC(=O)N1CCN(c2nn(-c3ccccc3)c3ccccc23)CC1,,O,,CN(C)C=O,,val
US20100249119A1,Cc1ccc(N)cc1O.O=C(Cl)c1cccc(C(F)(F)F)c1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1O,,C1CCOC1,,O,O=C([O-])O.[Na+],val
US20150038488A1,C[C@@H](Oc1cc(B2OC(C)(C)C(C)(C)O2)cc2ncn(C3CC3)c12)[C@H]1CNC(=O)C1.Cc1cc(I)nn1C>>Cc1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3c(c2)ncn3C2CC2)nn1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,ClCCl,N#N,O=C([O-])[O-].[Na+].[Na+],val
US20050266428A1,NCCCCCCCCCCCC(=O)O.O=C(OCc1ccccc1)ON1C(=O)CCC1=O>>O=C(O)CCCCCCCCCCCNC(=O)OCc1ccccc1,,CO,O,CCN(CC)CC,,val
US20060160794A1,CCOC(=O)c1nnn(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1O.COS(=O)(=O)OC>>CCOC(=O)c1nnn(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1OC,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20080161289A1,CC(C)(C)OC(=O)N1CCC(c2nc3c(s2)CCN(C2CCC2)CC3)CC1>>C1CC(N2CCc3nc(C4CCNCC4)sc3CC2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030004340A1,BrCCOc1ccccc1.CC1CNCCC1(C)c1cccc(-c2c[nH]nn2)c1>>CC1CN(CCOc2ccccc2)CCC1(C)c1cccc(-c2c[nH]nn2)c1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20090203677A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CN(Cc1ccc(F)c(-c2cccc(C=O)c2)c1)C(=O)C1(C(N)=O)CC1.CN1CCNCC1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CN(Cc1ccc(F)c(-c2cccc(CN3CCN(C)CC3)c2)c1)C(=O)C1(C(N)=O)CC1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20140206663A1,CC1(OS(C)(=O)=O)CN(C(c2ccccc2)c2ccccc2)C1.CC1C(=O)NN=C2COc3ccc(N)cc3N21>>CC1C(=O)NN=C2COc3ccc(NC4(C)CN(C(c5ccccc5)c5ccccc5)C4)cc3N21,,CC(C)O,,O=C([O-])[O-].[K+].[K+],,val
US20090163508A1,Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.Fc1cccc(-c2cc(N3CCNCC3)ncn2)c1F>>Cc1noc(NC(=O)N2CCN(c3cc(-c4cccc(F)c4F)ncn3)CC2)c1C,,C1CCOC1,CCCCCC,,,val
US04757080,C/C(N)=C/C(=O)OCCCCN1C(=O)c2ccccc2C1=O.COC(=O)C(=Cc1ccccc1[N+](=O)[O-])C(C)=O>>COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCCN2C(=O)c3ccccc3C2=O)C1c1ccccc1[N+](=O)[O-],,CCO,,,,val
US05219871,CNC(C)(C)CCC(C(N)=O)(c1ccccc1)c1ccccc1.Fc1ccc(CCBr)cc1>>CN(CCc1ccc(F)cc1)C(C)(C)CCC(C(N)=O)(c1ccccc1)c1ccccc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130004862A1,CS(=O)(=O)CC(O)CO.O=S(Cl)Cl>>CS(=O)(=O)CC1COS(=O)O1,,ClCCl,,,,val
US20100004269A1,O=[N+]([O-])c1ccc(C2CC2)cc1F>>Nc1ccc(C2CC2)cc1F,[Pd],,,,,val
US20120264734A1,CCN(c1cc(-c2ccc(N3CCNCC3)nc2)cc(C(=O)NCc2c(C(C)C)cc(C)[nH]c2=O)c1C)C1CCOCC1.CN1CCC(=O)CC1>>CCN(c1cc(-c2ccc(N3CCN(C4CCN(C)CC4)CC3)nc2)cc(C(=O)NCc2c(C(C)C)cc(C)[nH]c2=O)c1C)C1CCOCC1,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05246929,C=CCBr.CNCCCN1C(=O)C(c2ccc(Cl)cc2)Sc2ccc3ccccc3c21>>C=CCN(C)CCCN1C(=O)C(c2ccc(Cl)cc2)Sc2ccc3ccccc3c21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120142717A1,N#CC=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1>>N#C/C=C/c1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1,,ClCCl,O,[Na+].[OH-],,val
US20050227987A1,CCCc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc2ncncc2c1>>CCCc1ccc(S(=O)(=O)Nc2ccc3ncncc3c2)cc1,,ClCCl,,c1ccncc1,O=C([O-])O.[Na+],val
US20160200674A1,Nc1cc(Br)ccc1N(CCc1ccccc1)CCC(F)(F)F.Nc1ccc(C2CC2)c(F)c1.O=C(n1ccnc1)n1ccnc1>>O=C(Nc1ccc(C2CC2)c(F)c1)Nc1cc(Br)ccc1N(CCc1ccccc1)CCC(F)(F)F,,ClCCl,,,,val
US20110082137A1,COC1CCC(OC)O1.N#CCc1ccccc1N>>N#CCc1ccccc1-n1cccc1,,CC(=O)O,,,,val
US20060040918A1,NN.O=C(O)c1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)nc1>>NNC(=O)c1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)nc1,,C1CCOC1,CCOC(C)=O,O,O=S(Cl)Cl,val
US20150297586A1,Cc1ccc(N2CCNCC2)cc1.ClCCCCn1cnc2ccccc21>>Cc1ccc(N2CCN(CCCCn3cnc4ccccc43)CC2)cc1,,CC#N,,CCN(C(C)C)C(C)C,[I-].[K+],val
US20160002177A1,C[Si](C)(C)CCOCOc1cc(-c2ccccc2Cc2ccccc2)cc2c(=O)n(COCC[Si](C)(C)C)cnc12>>O=c1[nH]cnc2c(O)cc(-c3ccccc3Cc3ccccc3)cc12,,O=CO,,O,,val
US20090062366A1,COC(=O)c1ccc(CBr)cc1.C[C@H](c1cccc2ccccc12)N(C[C@H]1CNC[C@@H]1c1ccccc1)C(=O)OC(C)(C)C>>COC(=O)c1ccc(CN2C[C@H](c3ccccc3)[C@@H](CN(C(=O)OC(C)(C)C)[C@H](C)c3cccc4ccccc34)C2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130143863A1,COC(=O)N1CCc2nc(Cl)ccc2C1=O>>O=C1NCCc2nc(Cl)ccc21,,C1COCCO1,,C[O-].[Na+],,val
US20140135332A1,C=CCc1oc(C(CC)Oc2ccc(F)c(C(N)=O)c2F)nc1-c1ccc(Cl)cc1>>CCCc1oc(C(CC)Oc2ccc(F)c(C(N)=O)c2F)nc1-c1ccc(Cl)cc1,[Pd],CO,,,,val
US20090247567A1,CN(C)[C@@H]1CCNC1.O=C(O)c1ccc2c(c1)-c1sc(-c3ncnn3-c3ccc(F)cc3F)cc1CCO2>>CN(C)[C@@H]1CCN(C(=O)c2ccc3c(c2)-c2sc(-c4ncnn4-c4ccc(F)cc4F)cc2CCO3)C1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100173901A1,CC1Cc2ccc(-c3cc(C(=O)O)n(C)c3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1.CN>>CNC(=O)c1cc(-c2ccc3c(c2)CN(c2cc(N4CCN(C)CC4)nc(N)n2)C(C)C3)cn1C,,C1CCOC1,,,,val
US07060721B1,CCCI.Cc1ccc(O)cc1Cl>>CCCOc1ccc(C)c(Cl)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110245310A1,CC(C)(C)C(=N)N.COC1=C(Br)C(=O)CCC1>>CC(C)(C)c1nc2c([nH]1)CCCC2=O,,CN(C)C=O,ClCCl,Cl,O=C([O-])[O-].[K+].[K+],val
US20120142633A1,CCOC(=O)c1c(C)n(COCC[Si](C)(C)C)c2c(-c3c(OCC4CC4)ccc4c3OCO4)ccnc12>>Cc1c(C(=O)O)c2nccc(-c3c(OCC4CC4)ccc4c3OCO4)c2n1COCC[Si](C)(C)C,,C1COCCO1,,[Li+].[OH-],,val
US04874861,CC(C)(C)c1ccc(CSc2cnn(C(C)(C)C)c(=O)c2Cl)cc1.[Li]CCCC>>CCCCc1c(SCc2ccc(C(C)(C)C)cc2)cnn(C(C)(C)C)c1=O,,C1CCOC1,CCCCCC,,,val
US20100249198A1,C#C[C@@H](C)c1ccc(Cc2nc(C(F)(F)F)cs2)cc1.Cc1ccc(S(=O)(=O)N=[N+]=[N-])cc1>>Cc1ccc(S(=O)(=O)n2cc([C@H](C)c3ccc(Cc4nc(C(F)(F)F)cs4)cc3)nn2)cc1,[Cu]I,ClC(Cl)Cl,,,,val
US20150344481A1,C[Si](C)(C)CCOCn1cc(-c2ccc(F)cc2)nc1C=O>>C[Si](C)(C)CCOCn1cc(-c2ccc(F)cc2)nc1CO,,CO,,[BH4-].[Na+],,val
US20010046993A1,C=CC#N.c1ccc(CN2CCNCC2)cc1>>N#CCCN1CCN(Cc2ccccc2)CC1,,c1ccccc1,,,,val
US05585394,Nc1ccc(Cl)cc1NC1CCN(Cc2ccccc2)CC1.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]c2ccc(Cl)cc2n1C1CCN(Cc2ccccc2)CC1,,CC#N,,,,val
US06069145,COCCN1CCN(C(=O)OC(C)(C)C)CC1=O.O=C(O)C(F)(F)F>>COCCN1CCNCC1=O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04000313,ClCCN(Cc1ccccc1)Cc1ccccc1.Oc1ccc(OCc2ccccc2)cc1>>c1ccc(COc2ccc(OCCN(Cc3ccccc3)Cc3ccccc3)cc2)cc1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060116406A1,CCC(O)(c1cnc(S)s1)C(F)(F)F.O=c1oc2ccccc2c(-c2cc(F)cc(F)c2)c1F>>CCC(O)(c1cnc(Sc2ccc3c(-c4cc(F)cc(F)c4)cc(=O)oc3c2)s1)C(F)(F)F,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20060287386A1,COC(=O)c1ccccc1SSc1ccccc1C(=O)OC.O=S(=O)(Cl)Cl>>COC(=O)c1ccccc1SCl,,ClCCCl,,,,val
US20110065691A1,CCOC(=O)CC(=O)N1CCN(c2ccc(OC)c(OC3CCCC3)c2)C[C@@H]1Cc1ccccc1.CN>>CNC(=O)CC(=O)N1CCN(c2ccc(OC)c(OC3CCCC3)c2)C[C@@H]1Cc1ccccc1,,CCO,,[C-]#N.[Na+],,val
US20090318441A1,CCC(CC)n1c(C(=O)O)cc2cnc(Cl)nc21.CNC>>CCC(CC)n1c(C(=O)N(C)C)cc2cnc(Cl)nc21,,C1CCOC1,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20080269209A1,O=C1c2ccccc2C(=O)N1Cc1nn(-c2ccc(F)cc2)c2c1cc(-c1ccccc1)c1cnccc12>>NCc1nn(-c2ccc(F)cc2)c2c1cc(-c1ccccc1)c1cnccc12,,CCO,,NN,O,val
US20140045872A1,Cc1ccncc1I.O=C1NCCc2ccc(-c3ccc(F)cc3)cc21>>Cc1ccncc1N1CCc2ccc(-c3ccc(F)cc3)cc2C1=O,I[Cu]I,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20140066443A1,C=Cc1c(-c2ccc(CN3CC(=O)N(C)C3=O)cc2)ccc2c1nnn2CC1CC1>>CCc1c(-c2ccc(CN3CC(=O)N(C)C3=O)cc2)ccc2c1nnn2CC1CC1,[Pd],CCO,,,,val
US05201932,COC(=O)c1c(C)noc1C(=O)N1CCCCC1>>Cc1noc(C(=O)N2CCCCC2)c1C(=O)O,,CO,O,[Na+].[OH-],,val
US20120010183A1,CC(C)(C)OC(=O)OC(C)(C)C.O=C(O)c1c(F)cc(F)cc1F>>CC(C)(C)OC(=O)c1c(F)cc(F)cc1F,CN(C)c1ccncc1,CC(C)(C)O,,,,val
US20110065745A1,CC(Br)C(=O)c1ccccc1.Nc1ccc(Br)cn1>>Cc1c(-c2ccccc2)nc2ccc(Br)cn12,,CC(C)=O,,,,val
US20080221166A1,C=C[Mg]Br.COc1ccc(C=O)cc1OC>>C=CC(O)c1ccc(OC)c(OC)c1,,C1CCOC1,,[Cl-].[NH4+],,val
US04952571,COc1cc2cc(C(C#N)(C(C)CC#N)N3CCOCC3)sc2cc1OC.O>>COc1cc2cc(C(=O)C(C)CC#N)sc2cc1OC,,O,,CC(=O)O,,val
US20140288141A1,C=C(C)C(=O)Cl.CN(CCN(C)C(=O)OC(C)(C)C)Cc1cn(C2CCCCO2)nc1-c1ccc(N)cc1>>C=C(C)C(=O)Nc1ccc(-c2nn(C3CCCCO3)cc2CN(C)CCN(C)C(=O)OC(C)(C)C)cc1,,CO,ClCCl,O,,val
US06194454B1,COc1ccc(O)c2c1C(=O)CCC2>>COc1ccc(O)c2c1CCCC2,,O=C(O)C(F)(F)F,,,,val
US20090156612A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2ncn([C@@H]3CCCCC[C@@H]3OC(=O)c3ccc([N+](=O)[O-])cc3)c2-c2ccccc2)[C@H](Cc2ccccc2)C1>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ncn([C@@H]3CCCCC[C@@H]3O)c2-c2ccccc2)[C@H](Cc2ccccc2)C1,,O,,CCO,[Na+].[OH-],val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](O)CC2)c2ncnn12.CS(C)=O>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCSC)CC2)c2ncnn12,,O,,CC(=O)OC(C)=O,,val
US20040122098A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CON(C)C(=O)[C@H](CCCO)CCC(C)C>>CON(C)C(=O)[C@H](CCCO[Si](C)(C)C(C)(C)C)CCC(C)C,,ClCCl,,Cc1cccc(C)n1,,val
US20100041658A1,CCCc1ccc(OS(=O)(=O)c2ccc(C)cc2)c(OCc2ccccc2)c1>>CCCc1ccc(O)c(OCc2ccccc2)c1,,CCO,O,[K+].[OH-],,val
US20130052710A1,Brc1ccc2ccc3cccc4ccc1c2c34.C=Cc1nc2c(=O)[nH]c(N)nc2n1[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@@H](n2c(C=Cc3ccc4ccc5cccc6ccc3c4c56)nc3c(=O)[nH]c(N)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O,,CN(C)C=O,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150045368A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](N)CC1.O=[N+]([O-])c1cccnc1F>>CC(C)(C)OC(=O)NC1CCC(Nc2ncccc2[N+](=O)[O-])CC1,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US04299830,C=CCBr.O=[N+]([O-])c1ccc2c(c1)N1CCNC(C2)C1>>C=CCN1CCN2CC1Cc1ccc([N+](=O)[O-])cc12,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])O.[Na+],val
US20120322785A1,CC(C)OC(=O)Cl.Cc1ccc(F)cc1-c1ccc2cc(N)ncc2c1>>Cc1ccc(F)cc1-c1ccc2cc(NC(=O)OC(C)C)ncc2c1,,c1ccncc1,,,,val
US20150284409A1,C=CCO[C@@H](C)C[C@@H](C)C(NC(=O)OC(C)(C)C)C(=O)OCC>>C=CCO[C@@H](C)C[C@@H](C)C(NC(=O)OC(C)(C)C)C(=O)O,,CO,O,[Na+].[OH-],,val
US20160235734A1,CC(C)(C)[Si](C)(C)O[C@@H](CN=[N+]=[N-])c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12>>CC(C)(C)[Si](C)(C)O[C@@H](CN)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20080280876A1,C=CC(=O)OC.CC(C)Oc1ccc(-c2noc(-c3ccc(C(C)(C)N)cc3)n2)cc1Cl>>COC(=O)CCNC(C)(C)c1ccc(-c2nc(-c3ccc(OC(C)C)c(Cl)c3)no2)cc1,,CO,,CC(=O)O,,val
US05239075,C=CC(N)=O.CC(C)(C)c1ccc2c(c1)CCC(N1CCCC1)=C2>>CC(C)(C)c1ccc2c(c1)CCC1=C2CCC(=O)N1,,O,,,,val
US07015218B1,CC(C)COc1ccc(N)cc1C#N.Cc1c(C(=O)O)cnn1C>>Cc1c(C(=O)Nc2ccc(OCC(C)C)c(C#N)c2)cnn1C,,CCO,,On1nnc2ccccc21,,val
US20150344485A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1CCn2c(cc(Cl)nc2=O)N1>>CC1CCn2c(cc(Cl)nc2=O)N1C(=O)OC(C)(C)C,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,,val
US08614289B2,CC(C)C[C@H](NC(=O)[C@@H](N)[C@@H](C)O)C(=O)O.O=C(CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)NC(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)[C@@H](C)O)C(=O)O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US04073894,C=O.N#Cc1ccc(-n2oc(=S)[nH]c2=S)cc1>>N#Cc1ccc(-n2oc(=S)n(CO)c2=S)cc1,,CO,ClCCl,O,,val
US09296698B2,Brc1ccc2ccccc2n1.CCO.COC(=O)C=Cc1cnc2ccc(Br)cc2c1>>COC(=O)C=Cc1cnc2ccc(-c3ccccc3C)cc2c1,,CCO,,O,CC(=O)[O-].[K+],val
US05917043,CC(=O)C=O.CC1(C)CC(N)CC(C)(C)N1>>CC(=O)C=NC1CC(C)(C)NC(C)(C)C1,,COC(C)(C)C,,,,val
US20100010053A1,CCOC(=O)CCc1c[nH]c2c(-c3noc(-c4cnc(OC(C)C)c(C(F)(F)F)c4)n3)ccc(F)c12>>CC(C)Oc1ncc(-c2nc(-c3ccc(F)c4c(CCC(=O)O)c[nH]c34)no2)cc1C(F)(F)F,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20070099990A1,COc1c(C)c(NC(=O)OCC(Cl)(Cl)Cl)c(C)c2c1OCC2c1ccc(C(C)C)cc1.NCCO>>COc1c(C)c(NC(=O)NCCO)c(C)c2c1OCC2c1ccc(C(C)C)cc1,,CCCCCC,CCOC(C)=O,,,val
US20130079320A1,CC(C(=O)NCc1ccc(C(F)(F)F)nc1N1CCCC1)c1cccc(CN)c1.CS(=O)(=O)Cl>>CC(C(=O)NCc1ccc(C(F)(F)F)nc1N1CCCC1)c1cccc(CNS(C)(=O)=O)c1,,ClCCl,,CCN(CC)CC,,val
US20060142333A1,Nc1ccc2cccnc2c1.O=C(O)c1ccc2c(c1)C(=O)c1ccccc1-2>>O=C(Nc1ccc2cccnc2c1)c1ccc2c(c1)C(=O)c1ccccc1-2,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20120232056A1,COC(=O)c1ccc2nc(-c3cc4ccccc4o3)c(N3CCC[C@@H]3C)nc2c1>>C[C@H]1CCCN1c1nc2cc(C(=O)O)ccc2nc1-c1cc2ccccc2o1,,CO,,O,[Na+].[OH-],val
US20150225405A1,CCI.Cc1nc2[nH]cnc2cc1Br>>CCn1cnc2cc(Br)c(C)nc21,,CN(C)C=O,,[H-].[Na+],,val
US20070066820A1,CC(C)(C)OC(=O)CBr.c1ccc(Cc2ccc(OC[C@@H]3CCCN3)cc2)cc1>>CC(C)(C)OC(=O)CN1CCC[C@H]1COc1ccc(Cc2ccccc2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090291938A1,C=CCBr.CN1C(=O)CCN(C2CCCC2)c2nc(Cl)ncc21>>C=CCC1CN(C2CCCC2)c2nc(Cl)ncc2N(C)C1=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20130005707A1,C1=COCCC1.Cc1cc(I)cc2[nH]ncc12>>Cc1cc(I)cc2c1cnn2C1CCCCO1,,C1CCOC1,CCN(CC)CC,CS(=O)(=O)O,,val
US20030092720A1,CC(C)c1csc(CCc2cc3nc(N4CCCC(O)C4)c(/C=C/C(=O)OC(C)(C)C)c(=O)n3cc2F)n1>>CC(C)c1csc(CCc2cc3nc(N4CCCC(O)C4)c(/C=C/C(=O)O)c(=O)n3cc2F)n1,,C1COCCO1,Cl,,,val
US20090318385A1,COc1ccc(C(=O)O)c2cc(COC3CCCCO3)nn12>>COc1ccc(C(=O)O)c2cc(CO)nn12,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120136002A1,CCOC(=O)c1ccc(Cl)nc1Cl.N#Cc1ccc(O)cc1>>CCOC(=O)c1ccc(Oc2ccc(C#N)cc2)nc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130245043A1,O=C1CCC(=O)N1Cl.O=c1n(-c2ccc(F)cc2)ccc2nc(COc3ccccc3)cn12>>O=c1n(-c2ccc(F)cc2)ccc2nc(COc3ccccc3)c(Cl)n12,,CN(C)C=O,,,,val
US07368578B2,CCOC(=O)c1ccc(O)c(Cl)c1.Cc1oc(-c2ccco2)nc1CCl>>CCOC(=O)c1ccc(OCc2nc(-c3ccco3)oc2C)c(Cl)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110269751A1,CCN.ClCc1ccc(Cl)nc1>>C=CNCc1ccc(Cl)nc1,,CC#N,,O,,val
US20150353541A1,CCOC(=O)/C(Cl)=N/Nc1ccc(OC)cc1.O=C1C(Cl)=CCCN1c1ccc(I)cc1>>CCOC(=O)c1nn(-c2ccc(OC)cc2)c2c1CCN(c1ccc(I)cc1)C2=O,,O,,CCN(CC)CC,Cc1ccccc1,val
US20040147748A1,COC(Cc1cnc(NC(=O)OCc2ccccc2)cn1)OC>>COC(Cc1cnc(N)cn1)OC,[Pd],CO,,,,val
US20080255124A1,COC(=O)CN(CC(F)(F)F)c1ccc(C#N)c(C(F)(F)F)c1>>N#Cc1ccc(N(CCO)CC(F)(F)F)cc1C(F)(F)F,,C1CCOC1,,[BH4-].[Li+],,val
US20080315754A1,Brc1ccc(I)cc1.OB(O)c1cccc2c1oc1ccccc12>>Brc1ccc(-c2cccc3c2oc2ccccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20090197871A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2cc(OC)cc(-c3cccc(CN4CCN(C(=O)OC(C)(C)C)[C@@H](C)C4)c3)c2)c1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2cc(OC)cc(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US06040331,O=C1CCC2c3c1cccc3N(C(=O)c1ccccc1)C2c1ccccc1>>O=C1CCC2c3c(cccc31)NC2c1ccccc1,,CCO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20140288124A1,COCCBr.O=Cc1nn(C2CCCCO2)c2ccc(O)cc12>>COCCOc1ccc2c(c1)c(C=O)nn2C1CCCCO1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US06703082B1,CCOC(=O)C1CC=C(CCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)CC1>>O=C(O)C1CC=C(CCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)CC1,,CCO,O,[K+].[OH-],,val
US20130225552A1,O=[N+]([O-])c1cccnc1N[C@@H]1C[C@@H](Nc2nc3ccccc3s2)C1>>Nc1cccnc1N[C@@H]1C[C@@H](Nc2nc3ccccc3s2)C1,[Fe],CCO,O,[Cl-].[NH4+],,val
US06765114B1,O=C(CC1(C[N+](=O)[O-])CCCCC1)OCc1ccccc1>>NCC1(CC(=O)O)CCCCC1,[Pd],CO,,[H][H],,val
US20100160325A1,C[C@H](N)c1ncc(F)cn1.Cc1cc(Nc2nc(Cl)nc(N(C)S(=O)(=O)N(C)C)c2Cl)n[nH]1>>Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N(C)S(=O)(=O)N(C)C)c2Cl)n[nH]1,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20040082643A1,CCCC1(CC(=O)OCC)OCCc2c1[nH]c1c(C)ccc(C(=O)NC)c21>>CCCC1(CC(=O)O)OCCc2c1[nH]c1c(C)ccc(C(=O)NC)c21,,C1CCOC1,CO,[Na+].[OH-],,val
US20080027099A1,COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c2c1OC1CCCC1.O=C1CCC(=O)N1Br>>COc1ccc2c(Nc3c(Cl)cncc3Cl)c(Br)c(=O)[nH]c2c1OC1CCCC1,,O,,CN(C)C=O,,val
US04857517,O=C=O.c1ccc2c(c1)CCCCO2>>O=C(O)c1cccc2c1OCCCC2,,CCCCCC,O,CN(C)CCN(C)C,[Li]CCCC,val
US20080176906A1,CC(=O)c1c(C#N)c(-c2ccc(C#N)cc2)c(C)n1Cc1cnc(Cl)c(CO)c1.C[Mg]Br>>Cc1c(-c2ccc(C#N)cc2)c(C#N)c(C(C)(C)O)n1Cc1cnc(Cl)c(CO)c1,,C1CCOC1,,[Cl-].[Na+],,val
US20090143353A1,Cc1c(-c2cccc([N+](=O)[O-])c2)c(N2CC[C@H](N(C)C)C2)c2oc(C(C)(C)C)nc2c1C#N>>Cc1c(-c2cccc(N)c2)c(N2CC[C@H](N(C)C)C2)c2oc(C(C)(C)C)nc2c1C#N,,Cl,,,,val
US20120171245A1,Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(N[C@@H]4[C@@H](CO[Si](c5ccccc5)(c5ccccc5)C(C)(C)C)C[C@H]5C[C@@H]4C5(C)C)n3)c3cc(Cl)cnc32)cc1>>CC1(C)[C@H]2C[C@@H]1C[C@H](CO)[C@H]2Nc1nc(-c2c[nH]c3ncc(Cl)cc23)ncc1F,,C1COCCO1,CC#N,Cl,,val
US20080269059A1,C=COCCCC.O=C(Cl)C(F)(Cl)C(F)(F)F>>CCCCOC=CC(=O)C(F)(Cl)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US04698352,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.Cc1cc(O)ccc1-n1cc(C(=O)O)c(=O)cc1C=O>>CCOC(=O)C=Cc1cc(=O)c(C(=O)O)cn1-c1ccc(O)cc1C,,CO,,,,val
US20060014800A1,C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C>>C=C(c1ccc(CO)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20020013356A1,OC1c2ccccc2CCC1(Cc1ccccc1)c1c[nH]cn1>>c1ccc2c(c1)CCC1(c3c[nH]cn3)Cc3ccccc3C21,,CS(=O)(=O)O,,O,[Na+].[OH-],val
US20160257682A1,CC(C)(C)OC(=O)N1C[C@H](F)[C@H](O)C(C)(C)C1.Cl>>CC1(C)CNC[C@H](F)[C@@H]1O.Cl,,C1COCCO1,CCOCC,,,val
US20040259912A1,CC(C)(C)OC(=O)c1cc([N+](=O)[O-])ccc1O.OC(c1ccc(F)cc1)c1ccc(F)cc1>>CC(C)(C)OC(=O)c1cc([N+](=O)[O-])ccc1OC(c1ccc(F)cc1)c1ccc(F)cc1,,CC#N,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04152442,Cc1nnc(N)s1.O=Cc1ccccc1>>Cc1nnc(NCc2ccccc2)s1,,CCO,,[BH4-].[Na+],,val
US06040331,C1COCCN1.OC1CCc2c(-c3ccccc3)[nH]c3cccc1c23>>c1ccc(-c2[nH]c3cccc4c3c2CCC4N2CCOCC2)cc1,,ClCCl,,O,O=S(Cl)Cl,val
US20050090541A1,CC(C)(C)OC(=O)n1cccc1C=O.C[Si](C)(C)N(c1cccc([Mg]Cl)c1)[Si](C)(C)C>>CC(C)(C)OC(=O)n1cccc1C(O)c1cccc(N)c1,,C1CCOC1,,,,val
US20090170828A1,CC(C)(C)OC(=O)N1CC(Cc2ccccc2C(F)(F)F)C1.Cl>>Cl.FC(F)(F)c1ccccc1CC1CNC1,,ClCCl,,,,val
US20050272800A1,CC(C)(C)OC(=O)N1CC2CC2(CN2C(=O)c3ccccc3C2=O)C1c1ccccc1>>CC(C)(C)OC(=O)N1CC2CC2(CN)C1c1ccccc1,,CCO,,NN,,val
US06462036B1,O=S(=O)(Nc1ccc(-c2nn(S(=O)(=O)c3ccccc3)c3c2Cc2ccccc2-3)cc1)c1ccccc1>>O=S(=O)(Nc1ccc(-c2n[nH]c3c2Cc2ccccc2-3)cc1)c1ccccc1,,CO,,Cl,[Na+].[OH-],val
US20110070317A1,CCCC(=O)Nc1c[nH]c2ncc(Cl)c(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)c12>>CCCC(=O)Nc1c[nH]c2ncc(Cl)c(N3CCC[C@@H](N)C3)c12,,O=C(O)C(F)(F)F,,,,val
US04925861,Cc1nc(C(C)C)cs1.N#Cc1cccc(C=O)c1>>CC(C)c1csc(C=Cc2cccc(C#N)c2)n1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20040209921A1,Cc1c(C(C)C)ccc[n+]1[O-]>>CC(C)c1cccnc1CO,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US05641785,CCOC(=O)Cl.COC(=O)C1CCc2cc(OC)ccc2N1>>CCOC(=O)N1c2ccc(OC)cc2CCC1C(=O)OC,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20090286811A1,CCCCOc1c(C=O)cccc1OC.Cc1nc2sccn2c(=O)c1-c1ccc(OC(F)(F)F)cc1>>CCCCOc1c(/C=C/c2nc3sccn3c(=O)c2-c2ccc(OC(F)(F)F)cc2)cccc1OC,,CCO,,C,C[O-].[Na+],val
US20020173469A1,CI.COC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccn1>>COC(=O)[C@H](CC(C)C)N(C)C(=O)OCc1ccccn1,,C1CCOC1,O,CCOC(C)=O,[H-].[Na+],val
US06127570,BrBr.CCOC(=O)c1c(C)cccc1O>>CCOC(=O)c1c(O)ccc(Br)c1C,,CCOC(C)=O,O,CC(=O)O,,val
US20040037022A1,Cl.Cn1cccc1C(=O)Nc1ccc(C[C@@H](CO)N(C[C@H](O)COc2ccccc2)C(=O)OC(C)(C)C)cc1>>Cl.Cn1cccc1C(N)=O,,CCO,,,,val
US20110144090A1,CI.COc1c(Br)cc(F)c2[nH]cc(CC(=O)N(C)C)c12>>COc1c(Br)cc(F)c2c1c(CC(=O)N(C)C)cn2C,,CN(C)C=O,,[K+].[OH-],,val
US20060030613A1,CC(C)(C)c1ccc(CNCCc2ccc(C(F)(F)F)cc2)cc1.O=C(O)c1cccc2cc[nH]c12>>CC(C)(C)c1ccc(CN(CCc2ccc(C(F)(F)F)cc2)C(=O)c2cccc3cc[nH]c23)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20050234244A1,CC=NN(C(=O)c1ccccc1)c1ccc(OC)cc1.Cl>>COc1ccc(N(N)C(=O)c2ccccc2)cc1.Cl,,CO,Cc1ccccc1,,,val
US20070259846A1,Clc1nc2c(c(N[C@@H]3CCC[C@H]3OCc3ccccc3)n1)SCC2.Oc1ccc(N2CCNCC2)cc1>>c1ccc(CO[C@@H]2CCC[C@H]2Nc2nc(N3CCN(c4ccccc4)CC3)nc3c2SCC3)cc1,,C1COCCO1,,,,val
US20150258074A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)n1[nH]c(=O)c2cnc(Cl)cc21>>CC(C)(C)OC(=O)n1[nH]c(=O)c2cnc(Cl)cc21,,ClCCl,,CCN(CC)CC,,val
US20040186091A1,Clc1ccc2c(c1)CNCc1nnc(C3CCN(c4ccccn4)CC3)n1-2.Clc1ccncn1>>Clc1ccc2c(c1)CN(c1ccncn1)Cc1nnc(C3CCN(c4ccccn4)CC3)n1-2,,CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160030395A1,CCOC(O)C(Cl)(Cl)Cl.COc1cc(Br)ccc1N.NO>>COc1cc(Br)ccc1NC(=O)C=NO,,Cl,O,O=S(=O)([O-])[O-].[Na+].[Na+],,val
US20080161295A1,CN.O=S1(=O)N(CCBr)Cc2ccccc2N1c1ccccc1F>>CNCCN1Cc2ccccc2N(c2ccccc2F)S1(=O)=O,,CCO,,,,val
US20030139463A1,CC(C)NC(C)C.CCI.Clc1ccncc1I.[Li]CCCC>>CC(C)[N-]C(C)C.CCc1cncc(I)c1Cl.[Li+],,C1CCOC1,,,,val
US04788206,COc1ccc(C(=C/C=C/C(=O)Oc2ccc([N+](=O)[O-])cc2)c2ccc(OC)cc2)cc1.NCCCc1cccc2ccncc12>>COc1ccc(C(=C/C=C/C(=O)NCCCc2cccc3ccncc23)c2ccc(OC)cc2)cc1,,C1CCOC1,,,,val
US05589473,COc1cc(O[Si](C)(C)C(C)(C)C(C)C)c2c(c1C)C(=O)OC[C@@H](CO)CCC(=O)N[C@H](c1nc(C)no1)CSC2.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COc1cc(O[Si](C)(C)C(C)(C)C(C)C)c2c(c1C)C(=O)OC[C@@H](CN=[N+]=[N-])CCC(=O)N[C@H](c1nc(C)no1)CSC2,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04062858,CCCCN=C1c2ccccc2CCc2c1nc1c(cnn1CC)c2NCCCC.O=S(=O)(O)O>>CCCCNc1c2c(nc3c1cnn3CC)C(=O)c1ccccc1CC2,,CCOC(C)=O,CCOCC,,,val
US04496590,COc1ccc(Br)c(C(=O)O)c1.Nc1ccc(OCc2ccccc2)cc1>>COc1ccc(Nc2ccc(OCc3ccccc3)cc2)c(C(=O)O)c1,[Cu],CCCCCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US04654343,CCC(=O)Nc1cccc(-c2ccc3nncn3n2)c1.CI>>CCC(=O)N(C)c1cccc(-c2ccc3nncn3n2)c1,,O,,CN(C)C=O,[H-].[Na+],val
US20080015203A1,CC(C)[Si](OC[C@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)Nc2ccn(C(=O)OC(C)(C)C)n2)c1)(C(C)C)C(C)C>>CC(C)[Si](OC[C@H](C)Oc1cc(O)cc(C(=O)Nc2ccn(C(=O)OC(C)(C)C)n2)c1)(C(C)C)C(C)C,,C1CCOC1,CCO,,,val
US03981922,CCOC(=O)C=C(C)C=CCC(C)CCCC(C)C>>CC(C=CCC(C)CCCC(C)C)=CC(=O)O,,O,,CCO,[Na+].[OH-],val
US20030158245A1,CCO.CCOC(=O)c1sc(S(C)(=O)=O)c2c1CCc1cnn(C)c1-2>>CCOC(=O)c1sc(OCC)c2c1CCc1cnn(C)c1-2,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US04252984,BrCC1CO1.Oc1ccc(CCSCC2CCC2)cc1>>c1cc(OCC2CO2)ccc1CCSCC1CCC1,,O,,[Na+].[OH-],,val
US20160272632A1,CC(C)(C)OC(=O)N1CCC(=CC#N)CC1.O=C(O)C(F)(F)F>>N#CC=C1CCNCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20120202777A1,CC(CCc1ccc(-c2ccccc2O)cc1)(C(=O)NOC1CCCCO1)S(C)(=O)=O>>CC(CCc1ccc(-c2ccccc2O)cc1)(C(=O)NO)S(C)(=O)=O,,ClCCl,,CO,Cl,val
US20060069077A1,COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1O.N#CCBr>>COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCC#N,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080166359A1,CC(C)(C)OC(=O)N1CC(O)(C2C(=O)N(Cc3ccccc3)CC(=O)N2Cc2ccccc2)C1>>O=C1C(C2(O)CNC2)N(Cc2ccccc2)C(=O)CN1Cc1ccccc1,,CO,,C1COCCO1,Cl,val
US20090076046A1,O=S(=O)(c1ccccc1)n1cc(Cc2sc(NCc3cncc(F)c3)nc2Cl)c2cc(Cl)cnc21>>Fc1cncc(CNc2nc(Cl)c(Cc3c[nH]c4ncc(Cl)cc34)s2)c1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20090253687A1,Nc1ccccn1.O=C1COc2ccc(C(=O)C(Br)c3ccccc3)cc2N1>>O=C1COc2ccc(-c3c(-c4ccccc4)nc4ccccn34)cc2N1,,CC#N,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04766152,CCOC(CBr)OCC.Oc1ccc(Oc2ccccc2)cc1>>CCOC(COc1ccc(Oc2ccccc2)cc1)OCC,,CN(C)C=O,,[I-].[K+],,val
US20130079323A1,CCc1cc2c(Oc3cccnc3)nc(Cc3cccnc3)nc2[nH]1.O=C1CCC(=O)N1Cl>>CCc1[nH]c2nc(Cc3cccnc3)nc(Oc3cccnc3)c2c1Cl,,CN1CCCC1=O,,,,val
US20150329562A1,CC(=O)OC(C)=O.C[C@H]1CN(c2ccn(-c3cnnc(C(F)(F)F)c3)n2)C(=O)[C@@H]([C@@H](O)C(=O)OC(C)(C)C)O1>>CC(=O)O[C@@H](C(=O)OC(C)(C)C)[C@H]1O[C@@H](C)CN(c2ccn(-c3cnnc(C(F)(F)F)c3)n2)C1=O,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,c1ccncc1,,val
US20060004013A1,CCOOP(=O)(OOCC)C(NC(=O)OCc1ccccc1)C(=O)OC.COc1cc(C=O)ccc1-n1cnc(C)c1>>COC(=O)/C(=C/c1ccc(-n2cnc(C)c2)c(OC)c1)NC(=O)OCc1ccccc1,,CCOC(C)=O,ClCCl,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US08912207B2,CN(C)C=O.CSc1ncc(F)c(N)n1>>CSc1ncc(F)c(N=CN(C)C)n1,,CCOCC,,,,val
US20150284337A1,CS(=O)(=O)c1ccc(-c2ccc3c(=O)cn[nH]c3c2)cc1.O=C1CCC(=O)N1I>>CS(=O)(=O)c1ccc(-c2ccc3c(=O)c(I)n[nH]c3c2)cc1,,CCOC(C)=O,CN(C)C=O,CO,ClCCl,val
US20080146637A1,CC(C)(C)OC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)cc1NC(=O)OC(C)(C)C.O=S(=O)(c1ccccc1)C(O)CBr>>CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2S(=O)(=O)CCO)cc1NC(=O)OC(C)(C)C,,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US03962377,Cc1c(CCl)cc(C(C)(C)C)c(O)c1C.ClCCOP(OCCCl)OCCCl>>Cc1c(CP(=O)(OCCCl)OCCCl)cc(C(C)(C)C)c(O)c1C,,Cc1ccccc1C,,,,val
US20100125081A1,CI.Cc1cc(Br)cc(F)c1O>>COc1c(C)cc(Br)cc1F,,CC#N,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20110046377A1,Cc1nc2c3c(ccn2c1C)C(=O)[C@H](O)[C@@H](c1ccccc1)N3>>Cc1nc2c3c(ccn2c1C)[C@@H](O)[C@H](O)[C@@H](c1ccccc1)N3,,CO,O,[BH4-].[Na+],,val
US20140005382A1,CN1C(=O)COc2c1cccc2[N+](=O)[O-]>>CN1C(=O)COc2c(N)cccc21,[Pd],CCO,,,,val
US20080009486A1,C=C(N=Cc1cccc(I)c1)O[Si](C)(C)C.CC(C)(C)OC(=O)N1C(=O)/C(=C\c2cccc(Cl)c2)c2ccc(Cl)cc21>>O=C1CC(c2cccc(Cl)c2)C2(C(=O)Nc3cc(Cl)ccc32)C(c2cccc(I)c2)N1,,Cc1ccccc1,,,,val
US20090281060A1,CC(C)(C)OC(=O)N1CCNCC1.CS(=O)(=O)OCc1nc(-c2ccncc2)no1>>CC(C)(C)OC(=O)N1CCN(Cc2nc(-c3ccncc3)no2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150291595A1,CC1(C)OB(c2cccc(Cl)c2O)OC1(C)C.Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(Br)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12>>Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cccc(Cl)c3O)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12,,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20120077799A1,CCc1ccc(Oc2ccc(C3=CC=CN4CCS(=O)(=O)N=C34)cc2)cc1>>CCc1ccc(Oc2ccc(C3CCCN4CCS(=O)(=O)N=C34)cc2)cc1,O=[Pt]=O,C1CCOC1,CO,,,val
US20090239854A1,C=Cc1ccc(C)nc1.Cc1ccc2[nH]c3c(c2c1)C(=O)N(C)CC3O>>Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)C(O)CN(C)C1=O,,CN1CCCC1=O,,[K+].[OH-],,val
US04775743,O=C(CCc1ccc(OCc2ccccc2)cc1)OCc1ccccc1>>O=C(O)CCc1ccc(OCc2ccccc2)cc1,,CCO,,[K+].[OH-],,val
US20120276018A1,O=C(CCl)c1ccccc1.O=C(N[C@H]1CN2CCC1CC2)OC(c1ccccc1)c1ccccc1>>O=C(N[C@H]1C[N+]2(CC(=O)c3ccccc3)CCC1CC2)OC(c1ccccc1)c1ccccc1.[Cl-],,CCOC(C)=O,,,,val
US20100204246A1,C[C@H](Nc1nc(F)c(F)cc1[N+](=O)[O-])c1ncc(F)cn1.Cc1cc(N)n[nH]1>>Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)c([N+](=O)[O-])cc2F)n[nH]1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US05726192,COC(CN=C=S)OC.N>>COC(CNC(N)=S)OC,,CO,,,,val
US20120329780A1,COC(=O)c1cccc(-c2nc(Cl)c3nn(Cc4ccc(OC)cc4)cc3n2)c1.Nc1ccc2c(c1)NC(=O)CC2>>COC(=O)c1cccc(-c2nc(Nc3ccc4c(c3)NC(=O)CC4)c3[nH]ncc3n2)c1,C1COCCO1,CO,,Cl,,val
US20150291623A1,CC(C)(C)OC(=O)Nc1ccc(CN2C(=O)C3(COc4cc5c(cc43)OCCO5)c3ccccc32)cn1>>Nc1ccc(CN2C(=O)C3(COc4cc5c(cc43)OCCO5)c3ccccc32)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150361031A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(Cl)cc2C(=O)Nc2ccc([N+](=O)[O-])cc2Cl)CC1>>O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1OC1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06107458,CC(C)CCCO.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCCCC(C)C)cc1,,c1ccncc1,,CCOC(C)=O,O,val
US05863936,O=C(O)CC(=O)O.O=Cc1cccc(Cl)c1Cl>>O=C(O)C=Cc1cccc(Cl)c1Cl,,c1ccncc1,,C1CCNCC1,Cl,val
US20120058984A1,CC(C)(C)OC(=O)n1cc(B2OC(C)(C)C(C)(C)O2)cn1.N[C@@H]1CC[C@@H](Nc2nc(Cc3ccccc3)cc(Nc3nc4ccc(Cl)nc4s3)n2)CC1>>N[C@@H]1CC[C@@H](Nc2nc(Cc3ccccc3)cc(Nc3nc4ccc(-c5cn[nH]c5)nc4s3)n2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100324041A1,CC(C)Br.CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(F)c(O)cnc21>>CC(C)Oc1cnc2c(ccn2[Si](C(C)C)(C(C)C)C(C)C)c1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06077853,COC(=O)c1ccc(C#N)c(O)c1>>N#Cc1ccc(CO)cc1O,,C1CCOC1,,[BH4-].[Li+],,val
US03933829,CCCCN1CCC(N)CC1.O=S(=O)(Cl)c1ccc(Nc2ccnc3cc(Cl)ccc23)cc1>>CCCCN1CCC(NS(=O)(=O)c2ccc(Nc3ccnc4cc(Cl)ccc34)cc2)CC1,,ClC(Cl)Cl,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20160075653A1,NO.O=C1CCC1c1ccccc1C(F)(F)F>>ON=C1CCC1c1ccccc1C(F)(F)F,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20160158207A1,C1=COCCC1.CC(=O)N1CCc2[nH]nc(Br)c2C1>>CC(=O)N1CCc2c(c(Br)nn2C2CCCCO2)C1,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050124605A1,CCOC(=O)CN.COc1cc(N)c(C(=N)c2ccccc2)cc1OC>>COc1cc2c(cc1OC)C(c1ccccc1)=NCC(=O)N2,,c1ccncc1,,Cl,,val
US20090247534A1,Brc1ccc(Br)nc1.COC(=O)CC1CCC(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1>>COC(=O)CC1CCC(c2ccc(-c3ccc(Br)cn3)cc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20070179173A1,CC(C)c1ccc(N)cc1.COc1ccc(CC2SC(=O)NC2=O)c2c1N(Cc1ccc(C(=O)O)cc1)C(=O)CC2>>COc1ccc(CC2SC(=O)NC2=O)c2c1N(Cc1ccc(C(=O)Nc3ccc(C(C)C)cc3)cc1)C(=O)CC2,,CN(C)C=O,O,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20100190775A1,CSc1ncc2c(n1)N1CCC[C@H]1CN(c1cccc(C(N)=NO)c1)C2=O.O=COCCl>>CSc1ncc2c(n1)N1CCC[C@H]1CN(c1cccc(-c3noc(=O)[nH]3)c1)C2=O,,ClC(Cl)Cl,c1ccncc1,,,val
US20110028492A1,Fc1cccc(CNc2cccc(-c3cc(F)ncc3Cl)n2)c1.N[C@H]1CC[C@H](N)CC1>>N[C@@H]1CC[C@@H](Nc2cc(-c3cccc(NCc4cccc(F)c4)n3)c(Cl)cn2)CC1,,CS(C)=O,,CC#N,O,val
US20110077252A1,N#Cc1ccc(N)cn1.O=C(Cl)CCCl>>N#Cc1ccc(NC(=O)CCCl)cn1,,ClCCl,,CCN(CC)CC,,val
US20020098442A1,C=C(C)C(=O)Cl.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C.[Li]C>>C=C(C)C(=O)OC1(C)CC[C@@]2(C)C(CC[C@H]3[C@@H]4CC[C@H]([C@H](C)CCCC(C)C)[C@@]4(C)CC[C@@H]32)C1,,CCOCC,,,,val
US20040242572A1,C1CCNCC1.ClCc1ccncc1>>c1cc(CN2CCCCC2)ccn1,,CO,,,,val
US20100292207A1,O=C(Nc1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c2ccc(Cc3cc(F)cc(F)c3)cc12)c1cc(C(=O)N2CCC[C@H]2CN2CCCC2)ccc1F>>O=C(Nc1n[nH]c2ccc(Cc3cc(F)cc(F)c3)cc12)c1cc(C(=O)N2CCC[C@H]2CN2CCCC2)ccc1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080312232A1,CC1(C)OC(=O)C(=CNc2ccsc2)C(=O)O1>>Oc1ccnc2ccsc12,,COC(C)(C)C,,c1ccc(Oc2ccccc2)cc1,,val
US20100286112A1,COc1ccc(/C=C(\NC(C)=O)C(=O)O)c(F)c1>>COc1ccc(CC(NC(C)=O)C(=O)O)c(F)c1,[Pd],CCO,,,,val
US08507683B2,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc([N+](=O)[O-])c(OS(=O)(=O)C(F)(F)F)cc12.COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)ccc1OC>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc([N+](=O)[O-])c(-c3ccc(OC)c(C(=O)OC)c3)cc12,,C1COCCO1,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20050101650A1,C1CCNC1.O=C(c1cc(I)c[nH]1)C(Cl)(Cl)Cl>>O=C(c1cc(I)c[nH]1)N1CCCC1,,CC#N,,,,val
US20080194633A1,CC(C)(C)OC(=O)NCC(=O)O.COC(=O)C1(CO)CCNCC1>>COC(=O)C1(CO)CCN(C(=O)CNC(=O)OC(C)(C)C)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140194411A1,O=C(N1CCc2ccc3c(c2CC1)C(c1nccs1)=CC3)C(F)(F)F>>O=C(N1CCc2ccc3c(c2CC1)C(c1nccs1)CC3)C(F)(F)F,[Pd],CCO,,[H][H],,val
US20120270875A1,CCCI.Cc1nc(NCCCc2cccc3[nH]ncc23)nc(C)c1C(=O)N[C@@H](CNC(=O)c1cccs1)C(=O)O>>CCCOC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1c(C)nc(NCCCc2cccc3[nH]ncc23)nc1C,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20050203151A1,COC(=O)COc1ccc2c(ccn2CCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)c1>>Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CCn1ccc2cc(OCC(=O)O)ccc21,,C1CCOC1,O,[Li+].[OH-],,val
US20080021217A1,CC(C)(C)OC(=O)NCc1nc(-c2c[nH]c3ncccc23)cs1>>NCc1nc(-c2c[nH]c3ncccc23)cs1,,Cc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,val
US20130150344A1,COc1cc(-n2cccn2)ccc1-n1cc(OC)c(=O)c(C(=O)C=CN(C)C)n1.NNc1cccc(Cl)c1>>COc1cc(-n2cccn2)ccc1-n1cc(OC)c(=O)c(-c2ccnn2-c2cccc(Cl)c2)n1,,CCO,,Cl,O=C(O)C(F)(F)F,val
US20160229814A1,CC1(O)CC(=O)OC(=O)C1.N#Cc1ccc(N)cc1Cl>>CC(O)(CC(=O)O)CC(=O)Nc1ccc(C#N)c(Cl)c1,,C1CCOC1,,Cl,,val
US20030069224A1,CCC(=O)c1ccc2c(c1O)C=CCO2.CCOC(=O)C=[N+]=[N-]>>CCOC(=O)C1C2COc3ccc(C(=O)CC)c(O)c3C21,,ClCCCl,,,,val
US20070225288A1,CCOC(=O)C1=C(c2ccccc2)c2ccc(OC)cc2C1=O.NO>>CCOC(=O)C1=C(c2ccccc2)c2ccc(OC)cc2C1=NO,,CCO,,Cl,c1ccncc1,val
US20100310512A1,CC(C)(C)OC(=O)N1CCCC1c1ncc(-c2ccc(Br)c3ccccc23)[nH]1.COC(=O)NC(C(=O)O)C(C)C>>COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc(Br)c3ccccc23)[nH]1)C(C)C,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140206681A1,Nc1nccn2c([C@H]3CN[C@@H](CO)CO3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12.O=C(n1ccnc1)n1ccnc1>>Nc1nccn2c([C@H]3CN4C(=O)OC[C@H]4CO3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080176857A1,CC(O)CS.CCc1cc2c(N3CCN(C(=O)Cc4ccccc4)CC3)nc(Cl)nc2s1>>CCc1cc2c(N3CCN(C(=O)Cc4ccccc4)CC3)nc(SCC(C)O)nc2s1,,CN(C)C=O,,,,val
US05527791,C=CCBr.O=C(O)C=Cc1cccc([N+](=O)[O-])c1>>C=CCOC(=O)C=Cc1cccc([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040023947A1,CC1(c2ccccc2)NCCc2c1[nH]c1ccccc21.O=C(Cl)c1ccc(F)c(F)c1>>CC1(c2ccccc2)c2[nH]c3ccccc3c2CCN1C(=O)c1ccc(F)c(F)c1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,,val
US20090048301A1,CCOC(=O)c1cccnc1OCc1ccc2c(c1)OCO2.NN>>NNC(=O)c1cccnc1OCc1ccc2c(c1)OCO2,,CC(C)O,,O,,val
US20120015970A1,O=C1CN(S(=O)(=O)c2ccccc2Cl)CCC12CCN(c1ccc(OC(F)(F)F)cc1)C2=O>>O=C1N(c2ccc(OC(F)(F)F)cc2)CCC12CCN(S(=O)(=O)c1ccccc1Cl)CC2O,,CO,,[BH4-].[Na+],,val
US06627651B1,CCCOCc1ccccc1OB(O)O.COC(=O)C1=Cc2cc(O)ccc2S(=O)(=O)CC1>>CCCOCc1ccccc1Oc1ccc2c(c1)C=C(C(=O)OC)CCS2(=O)=O,,CCN(CC)CC,,ClCCl,,val
US20100152158A1,Cc1cccc(Cl)c1S(=O)(=O)Cl.OCC1CCCCN1>>Cc1cccc(Cl)c1S(=O)(=O)N1CCCCC1CO,,ClCCl,,CCN(CC)CC,Cl,val
US20040229876A1,COc1cc2nccc(Oc3ccc(N)c(Cl)c3)c2cc1OC.Nc1nnc(C2CC2)s1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4nnc(C5CC5)s4)c(Cl)c3)c2cc1OC,,ClC(Cl)Cl,O,CCN(C(C)C)C(C)C,,val
US20090215728A1,CC(C)=O.O=C(O)c1cc(Br)ccc1O>>CC1(C)OC(=O)c2cc(Br)ccc2O1,,O=C(O)C(F)(F)F,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20080293933A1,CC(C)C1CC[C@@H](C)CC1OC(=O)Cl.COc1ccc(CN2C(=O)C(N)c3ccccc3-c3ccccc32)cc1>>COc1ccc(CN2C(=O)[C@@H](NC(=O)O[C@@H]3C[C@H](C)CC[C@H]3C(C)C)c3ccccc3-c3ccccc32)cc1,,C1CCOC1,,O,O=C([O-])[O-].[K+].[K+],val
US20120270867A1,Nc1ccc(F)cn1.O=C([O-])Cc1nc(N2CCOCC2)cc(=O)[nH]1>>O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)Nc1ccc(F)cn1,,C1CCOC1,,O,,val
US20060004069A1,CSCc1ccc(NC(=O)/C=C/c2cnn(C)c2-c2ccc(F)cc2)cc1.O=C(OO)c1cccc(Cl)c1>>Cn1ncc(/C=C/C(=O)Nc2ccc(CS(C)=O)cc2)c1-c1ccc(F)cc1,,C1CCOC1,,O=S([O-])[O-].[Na+].[Na+],,val
US20050288273A1,CN(C)C=C1CCCc2cc(N3C[C@H](Cn4ccccc4=O)OC3=O)ccc2C1=O.NN>>O=C1O[C@@H](Cn2ccccc2=O)CN1c1ccc2c(c1)CCCc1cn[nH]c1-2,,CCO,ClCCl,O,,val
US04959373,CC(=O)Cl.Nc1ccc(C(=O)N2CC3CC(CN(Cc4ccccc4)C3)C2)cc1>>CC(=O)Nc1ccc(C(=O)N2CC3CC(CN(Cc4ccccc4)C3)C2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US03932472,CCCCCC(O)CC[C@H]1CC[C@@H](O)[C@@H]1CCCCCCC(=O)OCC>>CCCCCC(O)CC[C@H]1CC[C@@H](O)[C@@H]1CCCCCCC(=O)O,,CO,O,Cl,[K+].[OH-],val
US20060116364A1,CC(=O)OC(C)=O.COc1ccc(C2CCc3cc(OC)ccc3C2)c(N)c1>>COc1ccc2c(c1)CCC(c1ccc(OC)cc1NC(C)=O)C2,,c1ccncc1,,O=C([O-])O.[Na+],,val
US04342870,Cc1nc2ccccn2c(=O)c1CCCl.O=C(c1ccc(F)cc1)C1CCNCC1>>Cc1nc2ccccn2c(=O)c1CCN1CCC(C(=O)c2ccc(F)cc2)CC1,,CC(=O)CC(C)C,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20080261957A1,Cc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3cccc(S(=O)(=O)NC(C)(C)C)c3)c1)=N2>>Cc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3cccc(S(N)(=O)=O)c3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110190334A1,Cc1c(Nc2ccc(I)cc2F)c(N)c2n(c1=O)CCS2.O=S(=O)(Cl)C1CCC1>>Cc1c(Nc2ccc(I)cc2F)c(NS(=O)(=O)C2CCC2)c2n(c1=O)CCS2,,c1ccncc1,,,,val
US05834468,NCc1cccnc1.O=C(Cl)c1ccc(SCc2ccccc2OCc2ccccc2)cc1>>O=C(NCc1cccnc1)c1ccc(SCc2ccccc2OCc2ccccc2)cc1,,ClCCl,ClCCl,CCN(CC)CC,,val
US20090054435A1,COCOc1cc(OC)ccc1C(=O)c1ccc(OCc2nc(-c3ccccc3)oc2C)cc1C>>COc1ccc(C(=O)c2ccc(OCc3nc(-c4ccccc4)oc3C)cc2C)c(O)c1,,CC(C)=O,,Cl,,val
US20120130129A1,COc1ccc(/C=C/CCC(=O)O)c(OS(=O)(=O)c2ccc(C)cc2)c1OC>>COc1ccc(CCCCC(=O)O)c(OS(=O)(=O)c2ccc(C)cc2)c1OC,[Pd],CCO,CO,,,val
US20020028938A1,CC(=O)OC(C)=O.CC(C)(CO)COc1c(-c2ccc(S(N)(=O)=O)cc2)cnn(CC(F)(F)F)c1=O>>CC(=O)NS(=O)(=O)c1ccc(-c2cnn(CC(F)(F)F)c(=O)c2OCC(C)(C)CO)cc1,CN(C)c1ccncc1,,,CCN(CC)CC,,val
US20040116694A1,Cc1ccc2c([N+](=O)[O-])cccc2n1.O=C1CCC(=O)N1Br>>O=[N+]([O-])c1cccc2nc(CBr)ccc12,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20160108056A1,CC(C)(c1ccc(F)cc1)c1cc(C#C[Si](C)(C)C)cc(NC(=O)c2cc3ccc(NS(C)(=O)=O)cc3[nH]2)c1>>C#Cc1cc(NC(=O)c2cc3ccc(NS(C)(=O)=O)cc3[nH]2)cc(C(C)(C)c2ccc(F)cc2)c1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20160002175A1,NCCc1ccc(S(N)(=O)=O)cc1.Nc1nc(Cl)cc(-c2cccc(Cl)c2Cl)n1>>Nc1nc(NCCc2ccc(S(N)(=O)=O)cc2)cc(-c2cccc(Cl)c2Cl)n1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US05110955,COc1c(C)c(C)c(OC)c(CC/C(C)=C\COC(C)=O)c1C>>CC(=O)OC/C=C(/C)CCC1=C(C)C(=O)C(C)=C(C)C1=O,,CC#N,O,,,val
US20040254181A1,COC(OC)C(C#N)=CC1CCCCC1>>N#CC(C=O)=CC1CCCCC1,,Cl,,,,val
US20080090854A1,COC(=O)c1ccc2ccccc2c1OCC1COc2ccccc2O1>>O=C(O)c1ccc2ccccc2c1OCC1COc2ccccc2O1,,C1CCOC1,,CO,[Na+].[OH-],val
US04707478,Cc1cccc(OC(=N)NC#N)c1.NCc1ccncc1>>N#CNC(=N)NCc1ccncc1,,CC(C)O,,[Cl-].[Na+],,val
US20140364414A1,CN1c2cc(Br)ccc2NS1(=O)=O.C[Si](C)(C)CCOCCl>>CN1c2cc(Br)ccc2N(COCC[Si](C)(C)C)S1(=O)=O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20050277662A1,CC1(C)OC[C@@H](CO)O1.COC(=O)c1cc2c(CCl)cn(Cc3ccc(F)cc3F)c2cn1>>CC1(C)OC[C@@H](COCOC(=O)c2cc3cc[nH]c3cn2)O1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20060270690A1,CCN(c1cccc(C(C)=O)c1)S(C)(=O)=O.COC(OC)N(C)C>>CCN(c1cccc(C(=O)C=CN(C)C)c1)S(C)(=O)=O,,CCOC(C)=O,CO,,,val
US20100041696A1,CC(C)(C)OC(=O)N1CCc2cc(NC(=O)c3cn[nH]c3)ccc2C1.Fc1ccc(CBr)cc1>>CC(C)(C)OC(=O)N1CCc2cc(NC(=O)c3cnn(Cc4ccc(F)cc4)c3)ccc2C1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060205816A1,CC(C)(C)OC(=O)CBr.O[C@H](c1ccccc1)[C@@H](OC1CCCCO1)c1ccccc1>>CC(C)(C)OC(=O)CO[C@H](c1ccccc1)[C@@H](OC1CCCCO1)c1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20130072492A1,FC(F)(F)C(F)(F)CCI.N#Cc1n[nH]c2ncccc12>>N#Cc1nn(CCC(F)(F)C(F)(F)F)c2ncccc12,,CCOC(C)=O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20070287725A1,C#CCN.O=[N+]([O-])c1c(Cl)nc2ccccc2c1Cl>>C#CCNc1c([N+](=O)[O-])c(Cl)nc2ccccc12,,ClCCl,,CCN(CC)CC,,val
US04652567,CN.O=C1CCc2ncc3ccccc3c2N1>>CNC1=Nc2c(ncc3ccccc23)CC1,Cl[Ti](Cl)(Cl)Cl,C1CCOC1,,,,val
US20020072526A1,CC(C)(C)OC(=O)n1ccc2cc(C(C)(C)O[SiH2]C(C)(C)C)ccc21.CC(C)(C)[Si](C)(C)Cl>>CC(C)(C)[Si](C)(C)Oc1ccc2[nH]ccc2c1,,CN(C)C=O,,c1c[nH]cn1,,val
US20140088121A1,CC(C)(C)C(=O)Cl.CN(C)c1cc2c(cc1Sc1nc3c(N)ncnc3n1CCCN)OCO2>>CN(C)c1cc2c(cc1Sc1nc3c(N)ncnc3n1CCCNC(=O)C(C)(C)C)OCO2,,ClCCl,,CCN(CC)CC,,val
US20100234636A1,C#CCN[C@@H]1CCc2ccccc21.O=C(O)C(=O)O>>C#CCN[C@@H]1CCc2ccccc21.O=C([O-])C(=O)[O-],,CC(C)O,,,,val
US20070105904A1,ClCc1ccc(Cl)cn1.Nc1ncccc1-c1cc(Cc2ccc(O)cc2)no1>>Nc1ncccc1-c1cc(Cc2ccc(OCc3ccc(Cl)cn3)cc2)no1,,CN(C)C=O,,C1CCOC1,[Na+].[OH-],val
US20120316151A1,CC(C)(C)OC(=O)N1CC(CC(=O)NN)C1.O=C=Nc1ccc(Br)cc1F>>CC(C)(C)OC(=O)N1CC(CC(=O)NNC(=O)Nc2ccc(Br)cc2F)C1,,ClCCl,,,,val
US20050059658A1,COc1ccc(C2(O)OC(=O)CC2(C)C)cc1[N+](=O)[O-].NN>>COc1ccc(C2=NNC(=O)CC2(C)C)cc1[N+](=O)[O-],,CCO,,O,,val
US20100003250A1,C1COCCN1.Clc1nc(Cl)c2cc[nH]c2n1>>Clc1nc(N2CCOCC2)c2cc[nH]c2n1,,ClCCl,,CCN(CC)CC,,val
US20090197856A1,CC(C)(C)OC(=O)N[C@@H]1CCN2CCn3c(c(C4CCCCC4)c4ccc(C(=O)O)cc43)-c3cccc1c32>>N[C@@H]1CCN2CCn3c(c(C4CCCCC4)c4ccc(C(=O)O)cc43)-c3cccc1c32,,C1COCCO1,ClCCl,Cl,,val
US20020156081A1,CCN(Cc1ccccc1)c1ccccc1.O=C1C(Br)=CC(Br)(Br)C=C1Br>>CCN(Cc1ccccc1)c1ccc(Br)cc1,,ClCCl,,,,val
US20020099089A1,COC(=O)c1ccccc1NC(=O)/C=C/c1cccc([N+](=O)[O-])c1>>O=C(/C=C/c1cccc([N+](=O)[O-])c1)Nc1ccccc1C(=O)O,,CO,,[Na+].[OH-],,val
US20100179322A1,ClC/C=C\CCl.O=C1CCc2ccc(O)cc2N1>>O=C1CCc2ccc(OC/C=C\CCl)cc2N1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20110263562A1,CCOC(=S)[S-].Nc1cc(O)ccc1O>>Oc1ccc2oc(S)nc2c1,,c1ccncc1,,Cl,,val
US04078076,O=[N+]([O-])c1ccc(C2CCOCC2)cc1>>Nc1ccc(C2CCOCC2)cc1,,Cl,,,,val
US20140316148A1,CCCCCCC=O.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>CCCCCCCOCC(O)C1OCC(O)C1O,[Pd],CO,,[H][H],,val
US20160031819A1,Br.O=[N+]([O-])c1ccc(O)c2ncccc12>>Br.O=[N+]([O-])c1ccc(O)c2ncccc12,,C1CCOC1,,,,val
US04318899,CC(=O)O.CC(C)COC(=O)Cl.CCN(CC)CC.CO.ClC(Cl)Cl>>Cl.NCCc1ccc(O)cc1,,CN(C)C=O,,[Na+].[OH-],,val
US20150005300A1,COc1ccc2c(-c3cccc(Cl)c3)n[nH]c(=O)c2c1.O=C(CBr)C1(c2ccc3c(c2)OC(F)(F)O3)CC1>>COc1ccc2c(-c3cccc(Cl)c3)nn(CC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c(=O)c2c1,,CN(C)C=O,O,[H-].[Na+],,val
US04018785,CCOC(=O)C(C)c1csc(Nc2ccccc2)n1.CI>>CCOC(=O)C(C)c1csc(=Nc2ccccc2)n1C,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20120059014A1,CC(C)c1noc(N2CCC([C@H](C)CCOc3cnc(N4C[C@H](NC(=O)OC(C)(C)C)[C@@H](N5CC[C@H](C)CC5=O)C4)nc3)CC2)n1>>CC(C)c1noc(N2CCC([C@H](C)CCOc3cnc(N4C[C@H](N)[C@@H](N5CC[C@H](C)CC5=O)C4)nc3)CC2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120232051A1,COc1cc(F)c(F)cc1-c1ccncc1N(CCS(C)(=O)=O)C(=O)c1cc(C(F)(F)F)nc(C(F)(F)F)c1.COc1cccc(B(O)O)c1OC>>CNc1cnccc1-c1cccc(OC)c1OC,,CCCCCCC,CCOC(C)=O,,,val
US03995060,CC(C)C(=O)Cl.Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1>>CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1,,c1ccncc1,,,,val
US20070105872A1,CCOC(=O)C(=O)C=CN(C)C.COCCNN>>CCOC(=O)c1ccnn1CCOC,,CCO,,Cl,,val
US20080275086A1,CC(C)(C)OC(=O)N1CC(C(=O)O)C1.NCc1ccccc1>>CC(C)(C)OC(=O)N1CC(C(=O)NCc2ccccc2)C1,,ClCCCl,,O=C(n1ccnc1)n1ccnc1,,val
US05545735,N[C@@H]1Cc2ccccc2CNC1=O.O=C(Cl)OCc1ccccc1>>O=C(N[C@@H]1Cc2ccccc2CNC1=O)OCc1ccccc1,,C1CCOC1,CCOCC,O=C([O-])[O-].[K+].[K+],,val
US06136810,CCc1ccc(C(=O)c2cccc(Cl)c2)c(=O)[nH]1.Cc1ccc(S(=O)(=O)Cl)cc1>>CCc1ccc(C(=O)c2cccc(Cl)c2)c(OS(=O)(=O)c2ccc(C)cc2)n1,CN(C)c1ccncc1,CC(Cl)Cl,,CCN(CC)CC,,val
US20120270857A1,COC(Cn1c(=O)[nH]c2cccc(C(=O)[O-])c21)OC>>COC(=O)c1cccc2[nH]c(=O)n(CC=O)c12,,ClCCl,,O,O=C(O)C(F)(F)F,val
US20030096812A1,C=O.CCC1(C)CN(Cc2ccccc2)CCC1N.CO>>CCC1(C)CN(Cc2ccccc2)CCC1N(C)C,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20120238559A1,O=C(Nc1cc(-c2ccnc3c2ccn3S(=O)(=O)c2ccccc2)cc2c1cnn2S(=O)(=O)c1ccccc1)c1ccco1>>O=C(Nc1cc(-c2ccnc3[nH]ccc23)cc2[nH]ncc12)c1ccco1,,CC(C)O,,Cl,[Na+].[OH-],val
US20090286836A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@@H]1CC[C@H](c2cc(-c3ccc(F)cc3C)c(N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cn2)N1>>COC(=O)[C@@H]1CC[C@H](c2cc(-c3ccc(F)cc3C)c(N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cn2)N1C(=O)OC(C)(C)C,,ClCCl,,,,val
US20030008882A1,COc1ccc(-c2ccc(-c3ccc(CCC#N)cc3CC(C)C)cc2Cc2ccccc2)cc1CC(C)C>>CC(C)Cc1cc(-c2ccc(-c3ccc(CCC#N)cc3CC(C)C)cc2Cc2ccccc2)ccc1O,,ClCCl,,BrB(Br)Br,O,val
US20110021522A1,Nc1cccc(-c2ccc3c(c2)CCO3)c1.O=C(O)c1cc2cccc(OC(F)(F)F)c2oc1=O>>O=C(Nc1cccc(-c2ccc3c(c2)CCO3)c1)c1cc2cccc(OC(F)(F)F)c2oc1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120142706A1,CC1(C(=O)O)CC1.Cc1cc(N(CC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)C(=O)OC(C)(C)C)ncc1N>>CC(C)(C)OC(=O)N(CC[C@@H]1C[C@@H]1C1CCN(c2ncc(Cl)cn2)CC1)c1ccc(NC(=O)C2(C)CC2)nc1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150284371A1,C[C@@H](NC1CCCCC1)C(=O)NC1CCCC1.O=C(O)Cn1nnc(-c2ccc3c(c2)OCO3)n1>>C[C@H](C(=O)NC1CCCC1)N(C(=O)Cn1nnc(-c2ccc3c(c2)OCO3)n1)C1CCCCC1,CN(C)c1ccncc1,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20160122342A1,COc1nc(C)cc(CO)c1C#N.CS(=O)(=O)Cl>>COc1nc(C)cc(COS(C)(=O)=O)c1C#N,,ClCCl,,CCN(CC)CC,,val
US04272437,CCCC(N=[N+]=[N-])C(=O)O.O=C(Cl)C(=O)Cl>>CCCC(N=[N+]=[N-])C(=O)Cl,,ClCCl,,CN(C)C=O,,val
US20120184587A1,COc1ccc(C(=O)O)cc1C#N.O=S(Cl)Cl>>COc1ccc(C(=O)Cl)cc1C#N,,CN(C)C=O,,Cc1ccccc1,,val
US07183297B2,COC(=O)c1ccc(-c2cc(N)ccc2C)cc1.O=C(Cl)c1ccnc(Cl)c1>>COC(=O)c1ccc(-c2cc(NC(=O)c3ccnc(Cl)c3)ccc2C)cc1,,ClCCl,,CCN(CC)CC,,val
US20150158851A1,C[Mg]Br.O=Cc1cncc(F)c1>>CC(O)c1cncc(F)c1,,CCOCC,,[Cl-].[NH4+],,val
US04334015,CC(C)(C)c1ccc(C(=O)O)cc1.CO>>COC(=O)c1ccc(C(C)(C)C)cc1,,CC(Cl)Cl,,O=S(=O)(O)O,,val
US05436334,Cc1ccc(S(=O)(=O)Cl)cc1.O=C(c1ccccc1)N1C[C@@H](Br)[C@H](OCCO)C1>>Cc1ccc(S(=O)(=O)OCCO[C@@H]2CN(C(=O)c3ccccc3)C[C@H]2Br)cc1,CN(C)c1ccncc1,Cc1ccccc1,,CCN(CC)CC,O,val
US04999378,COC(=O)c1ccc(OCC2CCCC2Nc2ccc(Cl)cc2)cc1>>O=C(O)c1ccc(OCC2CCCC2Nc2ccc(Cl)cc2)cc1,,CO,O,Cl,[Na+].[OH-],val
US20110306621A1,CC(=O)CBr.NC(=S)C1CC1>>Cc1csc(C2CC2)n1,,ClC(Cl)Cl,,Cc1ccccc1,,val
US20110263658A1,COCCCc1ccccc1-c1cc(C(F)(F)F)c(C(=O)OC)cn1>>COCCCc1ccccc1-c1cc(C(F)(F)F)c(CO)cn1,,CO,O,[BH4-].[Na+],,val
US20130281490A1,COC(=O)N(c1ccc(-c2ccccc2)cc1)[C@@H](C(=O)O)[C@@H](O)C(C)C.COC(=O)N(c1ccc(-c2ccccc2)cc1)[C@@H](C(=O)O)[C@H](O)C(C)C>>CC(C)[C@H]1OC(=O)[C@@H]1N(C)C(=O)Oc1ccc(-c2ccccc2)cc1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20060094707A1,CCOC(=O)C[C@H](Cc1ccc2[nH]ncc2c1COC(C)=O)C(=O)OCC>>COC(=O)C[C@H](Cc1ccc2[nH]ncc2c1CO)C(=O)OC,,CO,,O=C([O-])[O-].[K+].[K+],,val
US05441950,NCc1ccccn1.O=C(Cl)N1Cc2ccccc2Oc2ccc(Cl)cc21>>Cl.O=C(NCc1ccccn1)N1Cc2ccccc2Oc2ccc(Cl)cc21,,CCN(CC)CC,,,,val
US20160159789A1,CCOC(=O)[C@H]1CCc2c(sc3ncnc(Cl)c23)C1.Nc1cc2cn[nH]c2cn1>>CCOC(=O)[C@H]1CCc2c(sc3ncnc(Nc4cc5cn[nH]c5cn4)c23)C1,,CCO,,,,val
US20080009630A1,CC(COC(=O)Cl)c1ccccc1[N+](=O)[O-].NN>>CC(COC(=O)NN)c1ccccc1[N+](=O)[O-],,ClCCl,,,,val
US20100056532A1,CN(C)c1ccncc1.Cn1nc(C(F)(F)F)cc1-c1csc(NC(=O)OCc2ccccc2)c1C(=O)OC(C)(C)C>>Cn1nc(C(F)(F)F)cc1-c1csc(NC(=O)c2cc3ccccc3o2)c1C(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20030203926A1,O=C(O)c1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCOCC4)cc3)n2)cc1.O=C(c1ccco1)N1CCNCC1>>O=C(c1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCOCC4)cc3)n2)cc1)N1CCN(C(=O)c2ccco2)CC1,,C1CCOC1,ClCCl,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20050049274A1,CC(C)C[C@H](N)CO.O=C(Cl)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O>>CC(C)CC(CO)NC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O,,ClCCl,,ClC(Cl)Cl,,val
US20070265289A1,Cc1ccc(-c2cc(-c3ccccc3O)nc(N)n2)cn1>>CC1CCC(c2cc(-c3ccccc3O)nc(N)n2)CN1,O=[Pt],CC(=O)O,,[H][H],,val
US05840732,O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C1COC(=O)N1CCCCOc1cccn2ccnc12>>O=C1COC(=O)N1CCCCOc1cccn2c(C(=O)C(F)(F)F)cnc12,,ClCCl,,CCN(CC)CC,,val
US20080269208A1,CC(C)(C)OC(=O)N1CCC[C@@H]1CNC(=O)OCc1ccccc1>>O=C(NC[C@H]1CCCN1)OCc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140343092A1,COC(=O)C#CC(=O)OC.ON=C1CCOCC1>>COC(=O)c1[nH]c2c(c1C(=O)OC)COCC2,,Cc1ccccc1,,C1CN2CCN1CC2,,val
US20100113775A1,CN(C)C=O.C[C@H](c1ccccc1)N1CCO[C@@H](c2ccc(Br)cc2)C1>>C[C@H](c1ccccc1)N1CCO[C@@H](c2ccc(C=O)cc2)C1,,C1CCOC1,,[Li]CCCC,,val
US20050148623A1,COC(=O)N[C@@H](CSC)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C.O=S([O-])OO>>COC(=O)N[C@@H](CS(C)(=O)=O)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C,,O,,CO,,val
US20140200197A1,CC(C)(C)OC(=O)N[C@H](C(=O)Nc1cccc(F)c1OC[C@@H]1CN(C(=O)OC(C)(C)C)[C@H](COC(=O)NCC(F)(F)F)CO1)C(c1ccc(F)cc1)c1ccc(F)cc1>>N[C@H](C(=O)Nc1cccc(F)c1OC[C@@H]1CN[C@H](COC(=O)NCC(F)(F)F)CO1)C(c1ccc(F)cc1)c1ccc(F)cc1,,C1COCCO1,,Cl,,val
US20130261077A1,CN.O=C(O)Cc1nnc(-c2ccc(I)cc2)o1>>CNC(=O)Cc1nnc(-c2ccc(I)cc2)o1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050250792A1,NN=C(N)c1ccccn1.O=C1CCC(=O)O1>>O=C(O)CCc1nc(-c2ccccn2)n[nH]1,,CC(=O)N(C)C,,,,val
US20070105951A1,CCOCC.CC[Mg]Br.COC(=O)c1ccco1>>CCC(O)(CC)c1ccco1,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20110105761A1,CCCCCCCBr.CCc1ccc(-n2ccnc2)c(C(=O)O)c1>>CCCCCCCn1cc[n+](-c2ccc(CC)cc2C(=O)O)c1.[Br-],,C1CCOC1,,,,val
US04795486,CSc1nnc(N)c(=O)n1C.O=C(OO)c1cccc(Cl)c1>>Cn1c(S(C)=O)nnc(N)c1=O,,ClCCl,,,,val
US20110269956A1,CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2ccc3cc(-c4ccc5c(ccc6nc([C@@H]7CCCN7C(=O)OC(C)(C)C)[nH]c65)c4)ccc3c2)[nH]1>>c1cc2cc(-c3cnc([C@@H]4CCCN4)[nH]3)ccc2cc1-c1ccc2c(ccc3nc([C@@H]4CCCN4)[nH]c32)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050020652A1,CCOC(=O)C(C)(Cc1ccc(OCCC2CN(Cc3ccc4ccccc4c3)C(=O)N2C)cc1)Oc1ccccc1>>CN1C(=O)N(Cc2ccc3ccccc3c2)CC1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1,,CCO,,[Na+].[OH-],,val
US20010044407A1,C=CCc1ccc(OCC(=O)OC)c(OCC(=O)OCC)c1>>C=CCc1ccc2c(c1)OCC(=O)CO2,,C1CCOC1,,Cl,[H-].[Na+],val
US20120053173A1,CCOC(=O)CCN(C)C(=O)c1ccc(NC(CCCCSC)c2oc3ccc(OC)cc3c2C)cc1>>COc1ccc2oc(C(CCCCSC)Nc3ccc(C(=O)N(C)CCC(=O)O)cc3)c(C)c2c1,,CCO,,C1CCOC1,[Na+].[OH-],val
US20050137171A1,CC(=O)n1ncc2cc(O)ccc21.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(=O)n1ncc2cc(OS(=O)(=O)C(F)(F)F)ccc21,,ClCCl,,c1ccncc1,,val
US03932410,C=CCc1nnc(NC(=O)N(CCl)CCC=O)s1>>C=CCc1nnc(N2C(=O)N(CCl)CCC2O)s1,,O,,Cl,,val
US20140206681A1,C=CC1OC(=O)N2C[C@H](c3ncc4c(Cl)nccn34)CC[C@@H]12.O=C1CCC(=O)N1Br>>C=CC1OC(=O)N2C[C@H](c3nc(Br)c4c(Cl)nccn34)CC[C@@H]12,,CN(C)C=O,,,,val
US20150322043A1,COC(=O)c1ccc(O)cc1Cl.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Br)c(O)cc1Cl,,CC#N,,O=S(=O)(O)C(F)(F)F,,val
US20110311461A1,COc1cccc(N)c1.O=CC(=O)O.OB(O)c1csc2ccccc12>>COc1cccc(NC(C(=O)O)c2csc3ccccc23)c1,,CC#N,,O,,val
US20060020146A1,COc1ccc(COC(=O)NNC(=O)c2ccc3c(c2C)OCCO3)cc1>>Cc1c(C(=O)NN)ccc2c1OCCO2,,C1COCCO1,,Cl,,val
US20130261106A1,CC(C)Oc1cc(C2CCN(C)CC2O)ccc1NC(=O)OCc1ccccc1>>CC(C)Oc1cc(C2CCN(C)CC2O)ccc1N,,CO,,,,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4nccn4CCCC)cc2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4nccn4CCCC)cc2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20070161643A1,CC(C)(C)OC(=O)NCc1ccc(F)cc1CO.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)NCc1ccc(F)cc1CN=[N+]=[N-],,C1CCOC1,O,C1CCC2=NCCCN2CC1,,val
US20110092505A1,CC(C)(C)OC(=O)N1CCN(c2cc(C(N)=O)c(-c3ccccc3)c(-c3ccnc(NC4CCCCC4)c3)n2)CC1>>NC(=O)c1cc(N2CCNCC2)nc(-c2ccnc(NC3CCCCC3)c2)c1-c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120301817A1,COC(CC#N)OC.Cc1ccccc1.OCc1ccccc1>>N#CCC(OCc1ccccc1)OCc1ccccc1,,CCN(CC)CC,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20130005755A1,CN1CC[C@]23CC(=O)CC[C@@]2(O)[C@H]1Cc1ccc(C(=O)NCCc2ccc(Br)cc2)c(O)c13.COc1ncc(B(O)O)cn1>>COc1ncc(-c2ccc(CCNC(=O)c3ccc4c(c3O)[C@]35CCN(C)[C@H](C4)[C@]3(O)CCC(=O)C5)cc2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20090232747A1,CCOC(=O)C(C)(C)Br.CCS>>CCOC(=O)C(C)(C)SCC,,CCO,,[K+].[OH-],,val
US20060106020A1,C[Si](C)(C)CCOCCl.O=c1[nH]ccc2c3nc(Cl)n(Cc4ccccc4)c3c3ccc(F)cc3c12>>C[Si](C)(C)CCOCn1ccc2c3nc(Cl)n(Cc4ccccc4)c3c3ccc(F)cc3c2c1=O,,C1CCOC1,,O,CC(C)(C)[O-].[K+],val
US20130048075A1,CCCCCCCCN.O=C1OC(=O)c2cscc21>>CCCCCCCCNC(=O)c1cscc1C(=O)O,,Cc1ccccc1,,,,val
US20060229312A1,Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1.O=C1OCc2cccc(F)c21.O=S(Cl)Cl>>Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5c(F)cccc5CCl)c4)CC3)cccc2n1,,ClCCl,ClCCl,C[Al](C)C,,val
US20140018313A1,C[C@H]1CC[C@@H](C(=O)O)N1C(=O)OC(C)(C)C.O=C(CBr)c1ccc(Br)cc1>>C[C@H]1CC[C@@H](C(=O)OCC(=O)c2ccc(Br)cc2)N1C(=O)OC(C)(C)C,,CC#N,CCOC(C)=O,CCN(CC)CC,,val
US20060106048A1,COc1c2c(c3c(c1C(F)C#N)CC(C)(C)N=C3c1ccccc1)CC(C)(C)O2.O=S(=O)(c1ccccc1)N(F)S(=O)(=O)c1ccccc1>>COc1c2c(c3c(c1C(F)(F)C#N)CC(C)(C)N=C3c1ccccc1)CC(C)(C)O2,,C1CCOC1,,CCCCC,[Li]C(C)(C)C,val
US07312225B2,Clc1ncc(Br)c(Cl)n1.NCCCCCNC(=O)OCc1ccccc1>>O=C(NCCCCCNc1nc(Cl)ncc1Br)OCc1ccccc1,,CC#N,,CCN(CC)CC,O,val
US20060160803A1,CC(C)(C)c1cc([N+](=O)[O-])ccc1Cl>>CC(C)(C)c1cc(N)ccc1Cl,,CCOC(C)=O,,,,val
US20020082265A1,CC1(C)CC(O)C(C)(C)c2cc(C3OCCO3)c(Br)cc21>>CC1(C)CC(=O)C(C)(C)c2cc(C3OCCO3)c(Br)cc21,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20040082784A1,COc1cc(Cl)c([N+](=O)[O-])cc1F>>COc1cc(Cl)c(N)cc1F,,O,,Cl,,val
US20020107255A1,CC(=O)NCCN.CO.C[C@@H]1CN(Cc2ccc(F)cc2)[C@@H](C)CN1C(=O)COc1ccc(Cl)cc1CN>>CC(=O)NCCNC(=O)NCc1cc(Cl)ccc1OCC(=O)N1CC(C)N(Cc2ccc(F)cc2)CC1C,,ClCCl,,c1ccncc1,,val
US20120077814A1,CC1(C)O[C@H]2[C@H](c3cnn4c(N)ncnc34)O[C@H](CO)[C@H]2O1.NS(=O)(=O)Cl>>Nc1ncnc2c([C@@H]3O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]3O)cnn12,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20160016948A1,CC(C)n1cnc2cnc(Nc3ccnc(C4=CCN(C(=O)OC(C)(C)C)CC4)n3)cc21>>CC(C)n1cnc2cnc(Nc3ccnc(C4CCN(C(=O)OC(C)(C)C)CC4)n3)cc21,[Pd],CCOC(C)=O,CO,,,val
US20060004041A1,Cl.Cl.O=[N+]([O-])c1ccc2c(c1)CNCC2>>Cl.Cl.Nc1ccc2c(c1)CNCC2,O=[Pt]=O,CCO,,O,[Na+].[OH-],val
US20090054463A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Ic1ccc(-n2ccnn2)cc1>>CC1(C)OB(c2ccc(-n3ccnn3)cc2)OC1(C)C,,CS(C)=O,,CC(=O)[O-].[K+],,val
US20030013708A1,CC(=O)OC(C)=O.O=[N+]([O-])c1ccc(N2CCNCC2)cc1>>CC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20080194565A1,CC(C)(C)OC(=O)CC(=O)CCc1ccc(Br)cc1.CC(C)(C)[Si](C)(C)OCCBr>>CC(C)(C)OC(=O)C(CCO[Si](C)(C)C(C)(C)C)C(=O)CCc1ccc(Br)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20050084506A1,Cc1cc(Cl)ccc1N=C=O.c1ccc2c(c1)CNC2>>Cc1cc(Cl)ccc1NC(=O)N1Cc2ccccc2C1,,C1COCCO1,,,,val
US05633392,CC(=O)OC(C)=O.C[C@@]12C=CC[C@H]1c1ccc3cc(O)ccc3c1CC2>>CC(=O)Oc1ccc2c3c(ccc2c1)[C@@H]1CC=C[C@@]1(C)CC3,,CCOC(C)=O,,c1ccncc1,,val
US20070173488A1,O=C(Nc1nc2[nH]nc(-n3cncc3-c3ccccc3Cl)c2s1)C1CC1>>Nc1nc2[nH]nc(-n3cncc3-c3ccccc3Cl)c2s1,,CCO,O,[O-][Cl+3]([O-])([O-])O,,val
US20110021352A1,CCOC(=O)c1cc2cccnc2nc1C(F)(F)F>>O=C(O)c1cc2cccnc2nc1C(F)(F)F,,CCO,O,Cl,[Na+].[OH-],val
US20060135525A1,CC(=O)C(C)O.N#CCC#N>>Cc1oc(N)c(C#N)c1C,,CO,,CCNCC,,val
US20050043537A1,CCI.O=[N+]([O-])c1ccc(O)c(I)c1>>CCOc1ccc([N+](=O)[O-])cc1I,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20130190487A1,CON(C)C(=O)CC[C@H]1C(=O)N(c2ccc(F)cc2)[C@@H]1c1ccc(OCc2ccccc2)cc1.Fc1ccc([Mg]Br)cc1>>O=C(CC[C@H]1C(=O)N(c2ccc(F)cc2)[C@@H]1c1ccc(OCc2ccccc2)cc1)c1ccc(F)cc1,,C1CCOC1,,CCOC(C)=O,Cl,val
US20140179689A1,Cl.NC(=O)c1cccc(N)c1.Nc1nccc(Cl)n1>>Cl.NC(=O)c1cccc(Nc2ccnc(N)n2)c1,,CCO,,,,val
US07396844B1,CCOC(=O)c1ccc(C2=NCCN2)cc1.Cl>>Cl.O=C(O)c1ccc(C2=NCCN2)cc1,,CC(=O)O,,,,val
US20030045558A1,CCOC(=O)C(C)(C)Oc1cccc(OCCc2nc(-c3cccc(-c4ccccc4)c3)oc2C)c1>>Cc1oc(-c2cccc(-c3ccccc3)c2)nc1CCOc1cccc(OC(C)(C)C(=O)O)c1,,C1CCOC1,CCO,[Na+].[OH-],,val
US04416890,CCCCCCCC(=O)Cl.NS(=O)(=O)c1nc2ccc(O)cc2s1>>CCCCCCCC(=O)Oc1ccc2nc(S(N)(=O)=O)sc2c1,CN(C)c1ccncc1,c1ccncc1,,Cl,,val
US04054653,CN1Oc2cc(-c3ccccc3)[nH]c(=O)c2C1c1ccccc1>>Cn1c(-c2ccccc2)cc(O)c(C(=N)c2ccccc2)c1=O,[Pd],,,CCO,[H][H],val
US20070112005A1,CC(=O)N1CCN(C2CC(c3nc(I)c4c(Cl)nccn34)C2)CC1.N>>CC(=O)N1CCN(C2CC(c3nc(I)c4c(N)nccn34)C2)CC1,,CC(C)O,,,,val
US04497813,CC(C)(N)COc1ccc(O)c(C(N)=O)c1.N#Cc1ccccc1OCC1CO1>>CC(C)(COc1ccc(O)c(C(N)=O)c1)NCC(O)COc1ccccc1C#N,,C1COCCO1,,,,val
US20100222339A1,CCC(CC)c1cc(C)nc2c(-c3cnc(-c4ncnn4C)s3)c(C)nn12.O=C1CCC(=O)N1Cl>>CCC(CC)c1cc(C)nc2c(-c3sc(-c4ncnn4C)nc3Cl)c(C)nn12,,CC#N,ClCCl,,,val
US20090233908A1,CC(C)(C)OC(=O)N1CC[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1CO.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CC[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1COS(C)(=O)=O,,CCOC(C)=O,,CCN(CC)CC,O,val
US20130225554A1,O=C(NNC(=O)[C@H]1CC[C@H]2CN1C(=O)N2OCc1ccccc1)C1CC1>>O=C(NNC(=O)[C@H]1CC[C@H]2CN1C(=O)N2O)C1CC1,[Pd],CO,,[H][H],,val
US05559105,CCCCc1nc(I)c(C=O)n1C>>CCCCc1ncc(C=O)n1C,[Pd],CO,,CC(=O)[O-].[K+],,val
US20160237043A1,CC(C)(C)OC(=O)N1CCC(F)(C(=O)O)CC1.[NH4+]>>CC(C)(C)OC(=O)N1CCC(F)(C(N)=O)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120184565A1,C=CCNC.CN1Cc2c(Cl)nc(Cl)nc2C(c2ccc(F)cc2)C1>>C=CCN(C)c1nc(Cl)nc2c1CN(C)CC2c1ccc(F)cc1,,CN1CCCC1=O,,O,,val
US20040132994A1,Nc1c(N=O)cnn1CCO.O=S(=O)(O)O>>Nc1cnn(CCO)c1N.O=S(=O)(O)O,[Pd],O,,,,val
US20040235822A1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4nccn4CCCC(=O)NC)cc2)CCN3CC(C)C)cc1.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4nccn4CCCC(=O)NC)cc2)CCN3CC(C)C)cc1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20140171654A1,CCOC(OCC)c1cc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)c(-c2ccc(Cl)c(OC)c2F)n1>>COc1c(Cl)ccc(-c2nc(C=O)cc(N)c2F)c1F,,O,,CC#N,,val
US20140275092A1,CCc1c(CBr)[nH]c2c(C#N)cnn2c1=O.CN>>CCc1c(CNC)[nH]c2c(C#N)cnn2c1=O,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20060035949A1,C=C[Mg]Br.COC(=O)CCC/C=C\C[C@H]1C(=O)C=C[C@@H]1/C=C/[C@H](CCc1cc(Br)c(C)s1)O[Si](C)(C)C(C)(C)C>>C=CC1CC(=O)[C@H](C/C=C\CCCC(=O)OC)[C@H]1/C=C/[C@H](CCc1cc(Br)c(C)s1)O[Si](C)(C)C(C)(C)C,[Cu]I,C1CCOC1,,,,val
US05190959,O=[N+]([O-])c1ccccc1OCC#CCCl.c1ccc(C(OC2CCNCC2)c2ccccc2)cc1>>O=[N+]([O-])c1ccccc1OCC#CCN1CCC(OC(c2ccccc2)c2ccccc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06191150B1,CCC[C@@H](O)[C@@H](CC(C)C)C(=O)O.NOC1CCCCO1>>CCC[C@@H](O)[C@@H](CC(C)C)C(=O)NOC1CCCCO1,,CCOC(C)=O,ClCCl,ClCCCl,,val
US05965741,CC(=O)OC(C)=O.COC(=O)c1ccc(C)cc1O>>COC(=O)c1ccc(C)cc1OC(C)=O,,c1ccncc1,,,,val
US20120178770A1,Cn1c2c(c(-c3cccc(NS(=O)(=O)c4cccc(F)c4)c3)c1-c1ccnc(N)n1)C(=O)N(C(=O)OC(C)(C)C)CC2>>Cn1c2c(c(-c3cccc(NS(=O)(=O)c4cccc(F)c4)c3)c1-c1ccnc(N)n1)C(=O)NCC2,,C1COCCO1,Cl,,,val
US20060264435A1,C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O.O=S(=O)(c1ccc(Br)cc1)N1CCC1>>C[C@H](Oc1ccc(Cl)cc1-c1ccc(S(=O)(=O)N2CCC2)cc1)C(=O)O,,C1CCOC1,,,,val
US20030105074A1,CC(C)(C)OCC(O)CC1(O)CCN(C(=O)OC(C)(C)C)CC1.ClCc1ccccc1>>CC(C)(C)OCC(CC1(O)CCN(C(=O)OC(C)(C)C)CC1)OCc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20050020587A1,CC(=O)Cl.CC(C)(C)OC(=O)NC1CCNC1>>CC(=O)N1CCC(NC(=O)OC(C)(C)C)C1,,CCN(CC)CC,ClCCl,,,val
US06566364B2,COC(OC)N(C)C.COc1cc(C)c([N+](=O)[O-])cn1>>COc1cc2cc[nH]c2cn1,[Pd],CN(C)C=O,,C1CCNC1,,val
US20070173505A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OC[C@@H]1CC[C@@H]2CNCCN2C1>>CC(C)(C)OC(=O)N1CCN2CC(CO)CCC2C1,,C1COCCO1,,[K+].[OH-],,val
US20160030395A1,COc1cc(-c2c(C)noc2C)cc2c1NC(=O)C21OCCO1>>COc1cc(-c2c(C)noc2C)cc2c1NC(=O)C2=O,,CCOC(C)=O,,CC(=O)O,Cl,val
US20020077356A1,CCOC(=O)C(O)(CC(C)(C)c1cc(F)ccc1[N+](=O)[O-])C(F)(F)F>>CC(C)(CC(O)(C(=O)O)C(F)(F)F)c1cc(F)ccc1[N+](=O)[O-],,CCO,,,,val
US20020010176A1,CCOC(=O)C[C@H](NC(=O)NCCCc1ccc2c(n1)NCCC2)c1cccc(F)c1>>O=C(O)C[C@H](NC(=O)NCCCc1ccc2c(n1)NCCC2)c1cccc(F)c1,,CCO,,[Na+].[OH-],,val
US20160060273A1,CCOC(=O)C1(C)CCN(C2=NOC3(C2)CN(Cc2cc(OCC)c(-c4ccc(F)cc4)c(OCC)c2)C3)CC1>>CCOc1cc(CN2CC3(CC(N4CCC(C(=O)O)CC4)=NO3)C2)cc(OCC)c1-c1ccc(F)cc1,,CCO,,Cl,[Na+].[OH-],val
US04045556,NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)c1cc(=O)[nH]c(=O)[nH]1.O.O=C1N=CC(C(=O)O)=N1>>NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)C1=NC(=O)N=C1.O.O.O,,CCN(CC)CC,CN(C)C=O,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20050203113A1,NC1CCN(C(=O)OCc2ccccc2)CC1.O=C(Cl)CCCCCl>>O=C(CCCCCl)NC1CCN(C(=O)OCc2ccccc2)CC1,,ClCCl,,c1ccncc1,,val
US06168838A,CCCCCCBr.CCCCCCCCc1ccc2c(c1)c(F)cc1cc(O)ccc12>>CCCCCCCCc1ccc2c(c1)c(F)cc1cc(OCCCCCC)ccc12,,CN(C)C=O,,[H-].[Na+],,val
US06949550B2,CC(=O)Cl.CNCc1ccccc1N1CCC(N2CCc3c(C(N)=O)nn(-c4ccc(OC)cc4)c3C2=O)CC1>>COc1ccc(-n2nc(C(N)=O)c3c2C(=O)N(C2CCN(c4ccccc4CN(C)C(C)=O)CC2)CC3)cc1,,ClCCl,,c1ccncc1,,val
US20080234199A1,CCC(=O)c1ccc(O)c(OC)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCC(=O)c1ccc(OS(=O)(=O)C(F)(F)F)c(OC)c1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US04975461,COc1ccc2c(c1)CCC(=O)C2.Nc1ccc(OCc2ccccc2)cc1>>COc1ccc2c(c1)CCC(Nc1ccc(OCc3ccccc3)cc1)C2,,CO,,Cl,[BH3-]C#N.[Na+],val
US20160009716A1,CCn1c(-c2nc3cc(C(=O)N4CCCC(NC(=O)OC(C)(C)C)C4)ccc3n2C)cc2cnccc21>>CCn1c(-c2nc3cc(C(=O)N4CCCC(N)C4)ccc3n2C)cc2cnccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US05100575,[Li]CCCC.[Li]c1cccs1.c1ccsc1>>[Li]c1ccccc1.[Li]c1cccs1,,C1CCOC1,,,,val
US20160221945A1,CC1(O)C[C@@H](C(=O)NCc2cc(-c3ccc(OC(F)(F)F)cc3)ncn2)N(C(=O)OCc2ccccc2)C1.CCN(CC)S(F)(F)F>>CC1(F)C[C@@H](C(=O)NCc2cc(-c3ccc(OC(F)(F)F)cc3)ncn2)N(C(=O)OCc2ccccc2)C1,,ClCCl,,,,val
US20160214978A1,CS(=O)(=O)c1nc(Cl)cc(-c2c(C(F)(F)F)nc3ccc(F)cn23)n1.Nc1ccc(OC(F)(F)F)cc1>>Fc1ccc2nc(C(F)(F)F)c(-c3cc(Cl)nc(Nc4ccc(C(F)(F)F)cc4)n3)n2c1,,C1CCOC1,,,,val
US20100256156A1,COC(=O)c1ccc(N)cc1OC.Cc1oc(-c2ccccc2)cc1C(Cl)CC(C)C>>COc1cc(NC(CC(C)C)c2cc(-c3ccccc3)oc2C)ccc1C(=O)O,,CC(=O)N(C)C,O,[I-].[Na+],,val
US20090192162A1,CCOC(=O)COc1ccc(Sc2cc(C#CCN3CCOCC3)cc(Oc3cccc(C(F)(F)F)c3)c2)cc1C>>Cc1cc(Sc2cc(C#CCN3CCOCC3)cc(Oc3cccc(C(F)(F)F)c3)c2)ccc1OCC(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20120059030A1,COc1nc(-c2nnc3n2CCC[C@]3(Oc2cc(F)c(F)c(F)c2)C(C)(C)O)ccc1-n1cnc(C)c1.O=P(O)(O)O>>COc1nc(-c2nnc3n2CCC[C@]3(Oc2cc(F)c(F)c(F)c2)C(C)(C)OP(=O)(O)O)ccc1-n1cnc(C)c1,,CC(C)O,,,,val
US20130072679A1,CCS(N)(=O)=O.O=Cc1cncc(Br)c1Cl>>CCS(=O)(=O)NCc1cncc(Br)c1Cl,,CO,,[BH4-].[Na+],,val
US20100249187A1,O=S(Cl)Cl.OCc1ccc(-c2noc(-c3ccc(-c4ccccc4)c(F)c3)n2)cc1>>Fc1cc(-c2nc(-c3ccc(CCl)cc3)no2)ccc1-c1ccccc1,,ClCCl,,CN(C)C=O,,val
US20140315917A1,O=C(NCCCl)NC1CC1>>O=C1NCCN1C1CC1,,C1CCOC1,,[H-].[Na+],,val
US20070275968A1,CC#N.Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(Br)c2)n1.N#Cc1ccc(B(O)O)cc1.O>>Cc1cccc(-c2nc(C(C)C)[nH]c2-c2cccc(-c3ccc(CC(N)=O)cc3)c2)n1,,CCOC(C)=O,COCCOC,,,val
US20140073589A1,N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O.O=C(Cl)OCc1ccccc1>>O=C(N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O)OCc1ccccc1,,O,,Cl,,val
US20140228348A1,CO.O=C1CCCC(C(=O)O)C1>>COC(=O)C1CCCC(=O)C1,,CCOCC,,C[Si](C)(C)C=[N+]=[N-],,val
US20030199478A1,C1COCCN1.O=C(O)Cc1ccc([N+](=O)[O-])cc1>>O=C(Cc1ccc([N+](=O)[O-])cc1)N1CCOCC1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US04393210,CCOC(=O)NC=C(C(=O)OCC)c1ccc(Cl)cc1>>CCOC(=O)c1c[nH]c(=O)c2cc(Cl)ccc12,,c1ccccc1,,c1ccc(Oc2ccccc2)cc1,,val
US20090221663A1,COC(=O)c1ccc(-n2ncc(C(=O)OC(C)(C)C)c2SC2CCCC2)cc1>>COC(=O)c1ccc(-n2ncc(C(=O)O)c2SC2CCCC2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160115128A1,O=C(O)c1cc(F)c(F)cc1F.[OH-]>>O=C(O)c1cc(F)c(O)cc1F,,O,,Cl,,val
US05162318,COc1ccc(Cn2c(=O)n(CCN(C)C)c3cc(C(=O)c4ccccc4)ccc32)cc1>>CN(C)CCn1c(=O)[nH]c2ccc(C(=O)c3ccccc3)cc21,,CC#N,O,,,val
US06716961B2,NCCO.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>O=[N+]([O-])c1ccc(S(=O)(=O)NCCO)cc1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20150266837A1,CC(C)(C)OC(=O)NCCCNN.N#CBr>>CC(C)(C)OC(=O)NCCCN(N)C#N,,ClCCl,O,O=C([O-])[O-].[Na+].[Na+],,val
US20040006071A1,CCN(CC)CC.Cc1cc(C(=O)CBr)ccc1O.ClC(c1ccccc1)(c1ccccc1)c1ccccc1.NC=O>>Cc1cc(-c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)ccc1O,,CCOC(C)=O,CN(C)C=O,Cl,,val
US20110190257A1,CC1(C)OC[C@H](CONC(=O)c2ccc3sncc3c2Nc2ccc(I)cc2F)O1>>O=C(NOC[C@H](O)CO)c1ccc2sncc2c1Nc1ccc(I)cc1F,,C1COCCO1,CO,Cl,,val
US05475106,CN(C)c1ccc(N(CC(=O)OC(C)(C)C)C(=O)CN)cc1.Cc1cccc(N=C=O)c1>>Cc1cccc(NC(=O)NCC(=O)N(CC(=O)OC(C)(C)C)c2ccc(N(C)C)cc2)c1,,C1CCOC1,,,,val
US20050239818A1,COc1ccc([C@H]2CC=CC[C@H]2NC(=O)c2ccc(OCC3CC3)c(OCC3CC3)c2)cc1OC.O=C(OO)c1cccc(Cl)c1>>COc1ccc(C2CC3OC3CC2NC(=O)c2ccc(OCC3CC3)c(OCC3CC3)c2)cc1OC,,ClCCl,,,,val
US20050227995A1,CCC=O.O=Cc1cc(F)ccc1F.Sc1ccc(Cl)cc1>>CC(CO)C(Sc1ccc(Cl)cc1)c1cc(F)ccc1F,,CCO,,[Na+].[OH-],,val
US06096780,CN(C)C1CCC(=O)CC1.Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CCl)cc2)CCO3)cc1>>[Cl-].[NH3+]C1CCC(=O)CC1,,CN(C)C=O,,,,val
US20160000760A1,CC(C)(C)OC(=O)N1CC(COc2ccc(-c3c(Cl)cc(N)cc3C(F)(F)F)cc2)C1.Cl.S=C(Cl)Cl>>CC(C)(C)OC(=O)N1CC(COc2ccc(-c3c(Cl)cc(N=C=S)cc3Cl)cc2)C1,,ClCCl,O,O=C([O-])[O-].[Ca+2],,val
US06344470B1,CC(=O)Br.CCCN(c1nc(-c2ccc(OC)cc2Cl)c(C)s1)c1cc(N)ccc1OC>>CCCN(c1nc(-c2ccc(OC)cc2Cl)c(C)s1)c1cc(NC(C)=O)ccc1OC,,ClCCl,,CCN(CC)CC,,val
US20040138449A1,CNCC(O)c1ccc(NC(C)=O)cc1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2sc(CCl)cc21>>CC(=O)Nc1ccc(C(O)CN(C)Cc2cc3c(s2)c(=O)c(C(=O)NCc2ccc(Cl)cc2)cn3C)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20100240692A1,Cc1cc(SC(C)C)c2ccc3cccnc3c2n1.O>>CC(C)Sc1cc(C=O)nc2c1ccc1cccnc12,,O,,C1COCCO1,,val
US20140364432A1,CCc1cnc(Cl)nc1.Cc1nc(C(=O)N2CCC[C@@H](C)[C@H]2CN)c(-c2ccc(F)cc2)s1>>CCc1cnc(NC[C@@H]2[C@H](C)CCCN2C(=O)c2nc(C)sc2-c2ccc(F)cc2)nc1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20090176823A1,CC(C)(C)[SiH2]OC(C)(C)c1cc(CN)ccc1Cl.COC(=O)Cl>>COC(=O)NCc1ccc(Cl)c(C(C)(C)O[SiH2]C(C)(C)C)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060281771A1,CC(C)(C)OC(=O)NCC1CCNCC1.COc1cc2ncnc(Cl)c2cc1OC>>COc1cc2ncnc(N3CCC(CN)CC3)c2cc1OC,,CC(C)O,,ClCCl,O=C(O)C(F)(F)F,val
US05292760,CCOC(CC)(OCC)OCC.CNC(Cc1ccccc1N)c1ccsc1C>>CCC1=Nc2ccccc2CC(c2ccsc2C)N1C,,CCCCCC,,CC(=O)O,,val
US20160031868A1,Cc1noc(C)c1-c1ccc(N)c([N+](=O)[O-])c1.II>>Cc1noc(C)c1-c1cc(I)c(N)c([N+](=O)[O-])c1,,CCO,,,,val
US20160009720A1,CC1(C)OB(c2ccc(Cl)nc2)OC1(C)C.CNCC1CCCO1>>CN(CC1CCCO1)c1ccc(B2OC(C)(C)C(C)(C)O2)cn1,,CN(C)C=O,,CCN(CC)CC,,val
US20050009906A1,CN(C[C@@H]1CC[C@@H](C(=O)O)CC1)C(=O)OC(C)(C)C>>CNC[C@@H]1CC[C@@H](C(=O)O)CC1,,C1COCCO1,,Cl,,val
US20120202783A1,COC(=O)c1c(F)cccc1B1OC(C)(C)C(C)(C)O1.Clc1ncccn1>>COC(=O)c1c(F)cccc1-c1ncccn1,,COC(C)(C)C,O,O=C([O-])[O-].[Na+].[Na+],,val
US20030045558A1,CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3cccc(-c4ccccc4)c3)sc2C)cc1>>Cc1sc(-c2cccc(-c3ccccc3)c2)nc1CCOc1ccc(OC(C)(C)C(=O)O)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20160031810A1,CCC1(CC)c2cc([N+](=O)[O-])ccc2-c2ccc([N+](=O)[O-])cc21>>CC1(C)c2cc(N)ccc2-c2ccc(N)cc21,,CN(C)C=O,,NN,O,val
US04927964,BrBr.CON=C(C(C)=O)C(=O)O>>CON=C(C(=O)O)C(=O)CBr,,CC(=O)O,ClCCl,Br,,val
US04540699,CN(C)Cc1ccc(CSCCN)o1.O=c1[nH]c(N[N+](=O)[O-])ncc1Cc1ccn(Cc2ccccc2)c(=O)c1>>CN(C)Cc1ccc(CSCCNc2ncc(Cc3ccn(Cc4ccccc4)c(=O)c3)c(=O)[nH]2)o1,,c1ccncc1,,,,val
US20080287458A1,CC(=O)C(=O)Cl.CC(C)(O)CNS(=O)(=O)c1ccc(CCC(=O)c2ccc(Cl)cc2Nc2ccccc2)cc1>>CC(=O)C(=O)N(c1ccccc1)c1cc(Cl)ccc1C(=O)CCc1ccc(S(=O)(=O)NCC(C)(C)O)cc1,,Cc1ccccc1,,,,val
US20100120761A1,CN=C=S.NNC(=O)c1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1>>Cn1c(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n[nH]c1=S,,CCO,,,,val
US20050245529A1,CC1CCN(C2CCN(Cc3ccccc3)C2)CC1>>CC1CCN(C2CCNC2)CC1,[Pd],CO,,[H][H],,val
US06184225B2,COCCOc1cc2ncnc(Cl)c2cc1OC.Cc1cc(F)c(N)cc1O>>COCCOc1cc2ncnc(Nc3cc(O)c(C)cc3F)c2cc1OC.Cl,,CC(C)O,,,,val
US05114463,COCCl.COc1cc(OC)nc(Oc2cccc(Oc3nc(OC)cc(OC(F)F)n3)c2C(=O)O)n1>>COCOC(=O)c1c(Oc2nc(OC)cc(OC)n2)cccc1Oc1nc(OC)cc(OC(F)F)n1,,CN(C)C=O,,[H-].[Na+],,val
US04788185,NC(=O)c1ccc2nccn2c1>>N#Cc1ccc2nccn2c1,,O=P(Cl)(Cl)Cl,,,,val
US06358973B1,BrCCc1ccccc1.COc1cccc(CC#N)c1>>COc1cccc(C(C#N)CCc2ccccc2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20140128429A1,CN(C(=O)OC(C)(C)C)c1ccc(C(=O)c2cncn2C)cc1>>CNc1ccc(C(=O)c2cncn2C)cc1,,C1COCCO1,ClCCl,Cl,O=C([O-])O.[Na+],val
US20050020616A1,O=C(N1CC2CCC(C1)c1cc([N+](=O)[O-])c(O)cc12)C(F)(F)F>>Nc1cc2c(cc1O)C1CCC2CN(C(=O)C(F)(F)F)C1,[Pd],CCO,,,,val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Nc1cccc(S(F)(F)(F)(F)F)c1>>COc1ccc2nc(Nc3cccc(S(F)(F)(F)(F)F)c3)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US20120142707A1,C=C(C)C1CCC2(C(=O)O[Si](C)(C)C(C)(C)C)CCC3(C)C(CCC4C5(C)CC=C(c6ccc(C(=O)OC)cc6)C(C)(C)C5CCC43C)C12>>COC(=O)c1ccc(C2=CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC=C3[C@@H]5CC(C)(C)CC[C@]5(C(=O)O[Si](C)(C)C(C)(C)C)CC[C@]34C)C2(C)C)cc1,[Pd],,,,,val
US20080045686A1,C=C(C)C(=O)OCCO.O=C1CCC(=O)O1>>C=C(C)C(=O)OCCOC(=O)CCC(=O)O,,ClCCl,,CCN(CC)CC,,val
US20140142083A1,C=O.Cc1cc(C)c(CNC(=O)c2cc(C3=CCNCC3)cc(N(C)C3CCCC3)c2C)c(=O)[nH]1>>Cc1cc(C)c(CNC(=O)c2cc(C3=CCN(C)CC3)cc(N(C)C3CCCC3)c2C)c(=O)[nH]1,,CO,,[BH3-]C#N.[Na+],,val
US20130296301A1,C[C@@H](F)[C@H]1O[C@@H]2SC(N(C)C)=N[C@@H]2[C@H]2OC(C)(C)O[C@@H]21>>C[C@@H](F)[C@H]1O[C@@H]2SC(N(C)C)=N[C@@H]2[C@@H](O)[C@@H]1O,,CO,,Cl,[NH4+].[OH-],val
US20150210630A1,CON=C(CNC(=O)c1ccccc1C(F)(F)F)c1ncc(Br)cc1Cl.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CON=C(CNC(=S)c1ccccc1C(F)(F)F)c1ncc(Br)cc1Cl,,C1COCCO1,,[Na+].[OH-],,val
US20080015199A1,COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(OC)c2c(c1F)OCCCO2.NNc1ncccn1>>COc1cc(C(Nc2ccc(-c3noc(C)n3)cc2)c2nn(-c3ncccn3)c(=O)[nH]2)c(F)c2c1OCCCO2,,CN(C)C=O,,CCN(CC)CC,,val
US20100105667A1,CCOC(=O)c1ccc(-c2c(F)c(OC)cc(OC)c2F)c2cccnc12.COc1cc(OC)c(Cl)c(-c2ccc(C(=O)Nc3ccc(CN4CCN(C)CC4)cn3)c3nccnc23)c1Cl>>COc1cc(OC)c(F)c(-c2ccc(C(=O)Nc3ccc(CN4CCN(C)CC4)cn3)c3ncccc23)c1F,,CO,ClCCl,C[Al](C)C,,val
US20160031881A1,Fc1ccc(OC2CCN(c3nc4c(nc3NCC(F)F)CCNC4)CC2)c(F)c1.O=C(O)C(F)(F)F.O=C(OC(=O)C(F)F)C(F)F>>O=C(C(F)F)N1CCc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1.O=C(O)C(F)(F)F,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20100105744A1,CCO.CSCc1cccc2c(C(c3cnc(Br)s3)C3C(=O)OC(C)(C)OC3=O)c[nH]c12>>CCOC(=O)CC(c1cnc(Br)s1)c1c[nH]c2c(CSC)cccc12,[Cu],CCO,c1ccncc1,,,val
US04476132,CCCC(=O)c1cc2c(=O)c(C(=O)OCC)cn(CC)c2cc1C>>CCCC(=O)c1cc2c(=O)c(C(=O)O)cn(CC)c2cc1C,,CCO,,[Na+].[OH-],,val
US06177459B1,C1CCNC1.Cc1ccccc1OCc1ccccc1C(=O)Cl>>Cc1ccccc1OCc1ccccc1C(=O)N1CCCC1,,COC(C)(C)C,,O,,val
US20110294777A1,CC(C)(C)OC(=O)N1CCC(N)CC1.O=C(O)[C@@H]1CC[C@@H]2CN1C(=O)N2OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC(NC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)CC1,,ClCCl,,CCN(CC)CC,C[n+]1ccccc1Cl.[I-],val
US20160168090A1,C=O.OCC1COCCN1>>CN1CCOCC1CO,[Pd],CO,,,,val
US05194389,CCCCCCCCCCCCCCCCCCBr.Oc1ccc2ccccc2c1>>CCCCCCCCCCCCCCCCCCOc1ccc2ccccc2c1,,CCO,,[Na+].[OH-],,val
US20050043351A1,CC#N.NC(=O)O.Nc1n[nH]c2ccccc12.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O>>COC(=O)n1ncc2c(NC(=O)ON3C(=O)CCC3=O)cccc21,,CC#N,,c1ccncc1,,val
US20050192287A1,CN1CCC(C(=O)O)CC1.O=C(Cl)C(=O)Cl>>CN1CCC(C(=O)Cl)CC1,,ClCCl,,CN(C)C=O,,val
US20110142796A1,O=C(Cl)OCC1c2ccccc2-c2ccccc21.c1ccc(CN2CCC3(CC2)CNCCO3)cc1>>O=C(OCC1c2ccccc2-c2ccccc21)N1CCOC2(CCN(Cc3ccccc3)CC2)C1,,C1COCCO1,O,Cl,O=C([O-])O.[Na+],val
US20060111353A1,BrBr.CCOC(=O)C=CC1CCCCC1>>CCOC(=O)/C(Br)=C/C1CCCCC1,,ClC(Cl)(Cl)Cl,ClCCl,CCN(CC)CC,Cl,val
US20050020652A1,CCOC(=O)C(C)(Cc1ccc(OCCC2CN(Cc3ccc4ccccc4c3)C(=O)N2)cc1)Oc1ccccc1.CI>>CCOC(=O)C(C)(Cc1ccc(OCCC2CN(Cc3ccc4ccccc4c3)C(=O)N2C)cc1)Oc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20080090805A1,Nc1cc(C(=O)O)ccc1Sc1ccc(Cl)cc1C(=O)O>>O=C(O)c1ccc2c(c1)NC(=O)c1cc(Cl)ccc1S2,,C1CCOC1,,,,val
US20040034034A1,C[C@H]1CN(C(=O)COc2ccc(Cl)cc2CC(=O)O)[C@H](C)CN1Cc1ccc(F)cc1.NS(N)(=O)=O>>C[C@H]1CN(C(=O)COc2ccc(Cl)cc2CC(=O)NS(N)(=O)=O)[C@H](C)CN1Cc1ccc(F)cc1,,O=S(Cl)Cl,,,,val
US05556969,CC(C)CN1C(=O)C(NC(=O)Oc2ccc([N+](=O)[O-])cc2)N=C(C2CCCCCC2)c2ccccc21.CN1CCN(c2cccc(N)c2)CC1>>CC(C)CN1C(=O)C(NC(=O)Nc2cccc(N3CCN(C)CC3)c2)(C2CCCCCC2)N=Cc2ccccc21,,CN(C)C=O,,CCN(CC)CC,,val
US05145483,CC(=O)OC(C)=O.Nc1ccc(NC(=O)OCc2ccccc2)c(O)c1>>CC(=O)Nc1ccc(NC(=O)OCc2ccccc2)c(O)c1,,C1COCCO1,,,,val
US20120220609A1,Brc1ccc(Br)cc1.COc1ccc(C(=O)N(C)OC)cn1>>COc1ccc(C(=O)c2ccc(Br)cc2)cn1,,C1CCOC1,O,CCCCCC,[Li]CCCC,val
US20060155121A1,Cc1cc(N)cc(C)c1NC(=O)CC1CCCC1.O=Cc1ccc(C(F)(F)F)nc1>>Cc1cc(NCc2ccc(C(F)(F)F)nc2)cc(C)c1NC(=O)CC1CCCC1,,CC#N,,,,val
US20100273767A1,II.N#Cc1cccnc1>>N#Cc1cnccc1I,,C1CCOC1,,CC1(C)CCCC(C)(C)N1,[Li]CCCC,val
US20130225602A1,Fc1ccc2c(Br)cn(C3CC3)c2n1.OCc1ccccn1>>Brc1cn(C2CC2)c2nc(OCc3ccccn3)ccc12,,CO,CS(C)=O,[H-].[Na+],,val
US05246937,CC(=O)OCC(CCn1cnc2cnc(N)nc21)COC(C)=O>>CC(=O)OCC(CO)CCn1cnc2cnc(N)nc21,CC(=O)O,CO,,O=C([O-])[O-].[K+].[K+],,val
US05302720,CI.CNC(=S)Nc1ccccc1-c1ccccc1>>CN=C(Nc1ccccc1-c1ccccc1)SC.I,,CC(C)=O,,,,val
US04892578,CC1(C)CON(Cc2ccc(N)cc2Cl)C1=O.O=C1Cc2ccccc2C(=O)O1>>CC1(C)CON(Cc2ccc(NC(=O)Cc3ccccc3C(=O)O)cc2Cl)C1=O,,C1CCOC1,,,,val
US20100105744A1,CCOC(=O)CC(C)(O)c1ccc(C(F)(F)F)cc1>>CC(O)(CCO)c1ccc(C(F)(F)F)cc1,,C1CCOC1,ClCCl,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US20080146636A1,CC(C)(C)OC(=O)N[C@H]1CC[C@@H](N)CC1.Cc1ccc(F)c([N+](=O)[O-])c1>>Cc1ccc(N[C@@H]2CC[C@H](NC(=O)OC(C)(C)C)CC2)c([N+](=O)[O-])c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030158198A1,N#Cc1ccc(CO)cc1.O=C=Nc1cccc2cnccc12>>N#Cc1ccc(COC(=O)Nc2cccc3cnccc23)cc1,,CCOCC,,,,val
US04966905,CC1=CC(=O)C(C)(C)O1.O=Cc1cc(Cl)cc(Cl)c1>>CC1(C)OC(C=Cc2cc(Cl)cc(Cl)c2)=CC1=O,,CCO,,[Na+].[OH-],,val
US20150080549A1,CC(C)(C)OC(=O)N[C@@H](CCC(=O)O)C(=O)OCc1ccccc1.Fc1ccc(S)cc1>>CC(C)(C)OC(=O)N[C@@H](CCC(=O)Sc1ccc(F)cc1)C(=O)OCc1ccccc1,,ClCCl,,CC(C)N=C=NC(C)C,,val
US05648368,CC(C)(C)OC(=O)N[C@@H](CCOc1ccc(C2CNCCN2C(=O)OCc2ccccc2)cc1)C(=O)OC(C)(C)C>>N[C@@H](CCOc1ccc(C2CNCCN2C(=O)OCc2ccccc2)cc1)C(=O)O,,CCOC(C)=O,,Cl,,val
US05599814,CO.COc1cccc2[nH]c(=O)oc(=O)c12>>COC(=O)c1c(N)cccc1OC,,CO,,O,[Na+].[OH-],val
US20130137672A1,Cc1cc(C)nc(Cl)n1.O=C(c1c(F)cccc1-n1nccn1)N1C[C@@H]2CCNC[C@@H]21>>Cc1cc(C)nc(N2CC[C@H]3CN(C(=O)c4c(F)cccc4-n4nccn4)[C@H]3C2)n1,,CC#N,O,CCN(C(C)C)C(C)C,,val
US20050065099A1,C=CC(C)(C)O.Cc1c(O)cc2c(c1C)OC(C)(C)CC2>>CC(C)=CCc1c(O)c(C)c(C)c2c1CCC(C)(C)O2,,C1COCCO1,,FB(F)F,,val
US20130184294A1,Cc1cccnc1N.Cl>>CC1CCCNC1=N.Cl,O=[Pt],CCO,,[H][H],,val
US05393875,CC(C)(CO)S(=O)(=O)CC(Cc1ccccc1)C(=O)OCc1ccccc1.O=C(Cl)C1CC1>>CC(C)(COC(=O)C1CC1)S(=O)(=O)CC(Cc1ccccc1)C(=O)OCc1ccccc1,,c1ccncc1,,,,val
US20120052210A1,CCCCCCC=O.OCC(O)COCC(O)CO>>CCCCCCCOCC(O)COCC(O)CO,[Pd],O,,,,val
US20120329809A1,Cc1nc(N2CCN(C)CC2)c2nc(-c3ccccc3Cl)n(CCNC(=O)OC(C)(C)C)c2n1>>Cc1nc(N2CCN(C)CC2)c2nc(-c3ccccc3Cl)n(CCN)c2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100093723A1,C1COCCN1.CS(=O)(=O)OCC(O)c1cc2c(N)nc(-c3cccc(C#N)c3)nc2s1>>N#Cc1cccc(-c2nc(N)c3cc(C(O)CN4CCOCC4)sc3n2)c1,,CCOC(C)=O,,C1CCOC1,,val
US20140364412A1,C=O.CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)n(-c2ccc(Cl)c(OC3CCNCC3)c2)n1>>CN1CCC(Oc2cc(-n3nc(C(C)(C)C)cc3NC(=O)N[C@H]3CC[C@@H](Oc4ccc5nnc(N6CCCCC6)n5c4)c4ccccc43)ccc2Cl)CC1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100190747A1,CCCI.O=c1c2[nH]ccc2[nH]c(=S)n1-c1ccc(OCC(F)(F)F)cc1>>CCCSc1nc2cc[nH]c2c(=O)n1-c1ccc(OCC(F)(F)F)cc1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])O.[Na+],val
US20140364432A1,C=CCOC(=O)N1CCCC(C)C1CNc1ccc(C(F)(F)F)cn1>>C[C@@H]1CCCN[C@@H]1CNc1ccc(C(F)(F)F)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,C1COCCN1,,val
US20150094328A1,Cc1ccc2c(ccn2S(=O)(=O)c2ccccc2)n1>>Cc1ccc2[nH]ccc2n1,,CCO,,[Na+].[OH-],,val
US20070254873A1,CN.COCCCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(C=O)c4)cc23)CC1>>CNCc1cccc(-c2cc(C(N)=O)c3[nH]cc(C4CCN(S(=O)(=O)CCCOC)CC4)c3c2)c1,,CO,ClCCl,[BH4-].[Na+],,val
US20070219212A1,CC1=NCN(CCl)S1.CN1CCCC1=O.COC(=O)C[C@H]1OCCc2c1[nH]c1c(C)c(O)cc(C#N)c21>>CCC[C@]1(CC(=O)OC)OCCc2c1[nH]c1c(C)c(OCc3nnc(C)s3)cc(C#N)c21,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20090270351A1,C1CCOC1.C=C[Mg]Br.COc1ccc(P(=O)(Cl)Cl)cc1>>C=CP(=O)(C=C)c1ccc(OC)cc1,,CCOCC,,,,val
US20050054631A1,O=C(Cl)C(=O)Cl.c1ccc(Nc2ccccc2)cc1>>O=C1C(=O)N(c2ccccc2)c2ccccc21,,Cc1ccccc1,,Cl,,val
US20080261987A1,[N-]=[N+]=NCc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Cl)cc2)CC1>>NCc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Cl)cc2)CC1,,CO,,,,val
US20090253677A1,CC(C)(C)[Si](C)(C)OCC1CCC(C#N)(OCCO)CC1.NO>>CC(C)(C)[Si](C)(C)OCC1CCC(OCCO)(C(=N)NO)CC1,,CCO,,,,val
US20150065505A1,FC(F)(F)c1cccc(Br)c1.O=C1CCC2(CC1)OCCO2>>OC1(c2cccc(C(F)(F)F)c2)CCC2(CC1)OCCO2,,C1CCOC1,,[Li]CCCC,,val
US20100121048A1,CCCC[Mg]Cl.C[C@H](NC(=O)OC(C)(C)C)C(=O)c1ccccc1>>CCCCC(O)(c1ccccc1)[C@H](C)NC(=O)OC(C)(C)C,,C1CCOC1,,[Cl-].[NH4+],,val
US20060111375A1,CC(C)(C)c1nc2ncccc2cc1O.COc1cc2nccc(Cl)c2cc1OC>>COc1cc2nccc(Oc3cc4cccnc4nc3C(C)(C)C)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,O,,val
US20140031336A1,CC(=O)N1c2ccc(-c3ccc(C(=O)NCCNC(=O)OC(C)(C)C)cc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.Cl>>CC(=O)N1c2ccc(-c3ccc(C(=O)NCCN)cc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.Cl,,C1COCCO1,,,,val
US05593986,C=CC(=O)OC.OCc1ccccc1S>>COC(=O)CCSc1ccccc1CO,CCN(CC)CC,ClCCl,,,,val
US20150141644A1,COC(=O)c1cc2c(N3CCOCC3)nc(-c3ccc(N)cc3)nn2c1>>Nc1ccc(-c2nc(N3CCOCC3)c3cc(C(=O)O)cn3n2)cc1,,CCO,,CC(=O)O,[Na+].[OH-],val
US20060199836A1,COC(=O)c1ncc2c(Br)c(-c3ccc(F)cc3)sc2c1O.OB(O)c1ccc(F)cc1>>COC(=O)c1ncc2c(-c3ccc(F)cc3)c(-c3ccc(F)cc3)sc2c1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,C[O-].[Na+],,val
US20090012078A1,C1COCCN1.Nc1nc(CCl)cs1>>Nc1nc(CN2CCOCC2)cs1,,CCOC(C)=O,CN(C)C=O,Cl,,val
US20090264416A1,CC(C)(C)NC(=O)c1cccc(CCl)c1.C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1>>C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1Cc1cccc(C(=O)NC(C)(C)C)c1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20160102071A1,CC#CC(CC(=O)OCC)c1ccc(OCc2ccc3scc(-c4ccc(OC5CCOCC5)cc4C)c3c2)nc1>>CC#CC(CC(=O)O)c1ccc(OCc2ccc3scc(-c4ccc(OC5CCOCC5)cc4C)c3c2)nc1,,CCO,,Cl,[Li+].[OH-],val
US20100056527A1,CCOC(=O)c1cc(C)n[nH]1.ClCc1cc(Cl)cc2cc(-c3ccc(Cl)cc3Cl)oc12>>CCOC(=O)c1cc(C)n(Cc2cc(Cl)cc3cc(-c4ccc(Cl)cc4Cl)oc23)n1,,CCOC(C)=O,CN(C)C=O,[I-].[K+],O=C([O-])O.[Na+],val
US20140148454A1,CCOC(=O)NC(=O)C(C(=O)OC)=C(C)N>>COC(=O)c1c(C)[nH]c(=O)[nH]c1=O,,CCN(CC)CC,,,,val
US20090156573A1,O=[N+]([O-])c1ccc(N2CC3CC3C2)nc1>>Nc1ccc(N2CC3CC3C2)nc1,[Pd],,,,,val
US20100087427A1,CC(C)(C)OC(=O)N1C[C@H](CNc2ccc(Cl)cc2)[C@@H](Cc2ccccc2)C1.CCCOc1cc(C(F)(F)F)nc2ccc(CBr)cc12>>CCCOc1cc(C(F)(F)F)nc2ccc(CN(C[C@H]3CNC[C@@H]3Cc3ccccc3)c3ccc(Cl)cc3)cc12,,O,,CC#N,CC#N,val
US20030236297A1,C#CCCO.Oc1ccc(F)cc1>>C#CCCOc1ccc(F)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090291940A1,Cc1cc(O)c(C)c(O)n1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(OS(=O)(=O)C(F)(F)F)c(C)c(OS(=O)(=O)C(F)(F)F)n1,,ClC(Cl)Cl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US04328361,C=C(C)c1ccc(O)cc1.CC(=O)OC(C)=O>>C=C(C)c1ccc(OC(C)=O)cc1,O=S(=O)(O)O,O,,,,val
US20070155737A1,Cc1c(C(=O)OC(C)(C)C)ccc2c1CC[C@@H]2NC(=O)c1cc(C(=O)NCc2ccc(F)c(F)c2)nc2c(N)cnn12.O=C=Nc1ccccc1>>Cc1c(C(=O)OC(C)(C)C)ccc2c1CCC2NC(=O)c1cc(C(=O)NCc2ccc(F)c(F)c2)nc2c(NC(=O)Nc3ccccc3)cnn12,,ClCCl,,,,val
US20090131458A1,CC1(C)CC(CCBr)CCO1.CCCCNc1nc(N)c2nc(OC)nc-2[nH]1>>CCCCNc1nc(N)c2nc(OC)n(CCC3CCOC(C)(C)C3)c2n1,,CN(C)C=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20100021423A1,COc1ncccc1-c1cc(N(C)C(=O)c2ccc(NS(C)(=O)=O)cc2)c(OC)c(C(C)(C)C)c1>>COc1c(N(C)C(=O)c2ccc(NS(C)(=O)=O)cc2)cc(-c2ccc[nH]c2=O)cc1C(C)(C)C,,CC(=O)O,CCOC(C)=O,Br,,val
US20080234255A1,CCOC(=O)C(C)CN(c1nc(Cl)ncc1[N+](=O)[O-])C1CCCCC1>>CC1CN(C2CCCCC2)c2nc(Cl)ncc2NC1=O,[Fe],CC(=O)O,,,,val
US05869515,COc1ccc(CN)cc1.O=C(Cl)Oc1ccccc1>>COc1ccc(CNC(=O)Oc2ccccc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20150031668A1,COC(=O)c1cc[nH]c1C.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Br)[nH]c1C,,C1CCOC1,,,,val
US05294734,C=C(CCOC)C(O)C(NC=O)C(=O)OCC.O=S(Br)Br>>CCOC(=O)C(C=C(CBr)CCOC)NC=O,,ClCCCl,,O,,val
US20130261101A1,CC(Cl)c1cc(Cl)c(C#N)c2c1OCCN(C(=O)OC(C)(C)C)C2.Cc1n[nH]c2ncnc(N)c12>>Cc1nn(C(C)c2cc(Cl)c(C#N)c3c2OCCN(C(=O)OC(C)(C)C)C3)c2ncnc(N)c12,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US06262058B1,CCCNC(=S)Nc1sccc1C(=O)OC.CI>>CCCn1c(SC)nc2sccc2c1=O,,C1CCOC1,,[H-].[Na+],,val
US20140275503A1,CC1(C)OB(c2ccc(N=C=O)cc2)OC1(C)C.CCO[C@H]1[C@@H](OC)C(O)O[C@@H](C)[C@@H]1OC>>CCO[C@@H]1[C@@H](OC)[C@H](C)O[C@@H](OC(=O)Nc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)[C@@H]1OC,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04690943,CC(=O)OC(C)=O.O=C1Cc2cc(Cl)ccc2N1>>CC(=O)N1C(=O)Cc2cc(Cl)ccc21,,CCOC(C)=O,,,,val
US20160137647A1,CC1(C)CNC(CO)CO1.COc1cc(C(=O)O)cc2nc(NC(CF)c3cccc(Cl)c3)oc12>>COc1cc(C(=O)N2CC(C)(C)OCC2CO)cc2nc(NC(CF)c3cccc(Cl)c3)oc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160096839A1,C=CC[C@H](NC(=O)OC(C)(C)C)c1cc(-c2ccncc2NC(=O)[C@H](C)C=C)ccn1>>CC1C=CC[C@H](NC(=O)OC(C)(C)C)c2cc(ccn2)-c2ccncc2NC1=O,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20080058349A1,COC(CN)CN.COc1ccc(C2(c3cccc(Br)c3)NC(=S)SC2=S)cc1>>COc1ccc(C2(c3cccc(Br)c3)NC(=S)N3CC(OC)CN=C32)cc1,,CCO,,CCN(CC)CC,,val
US20140031355A1,CC(O)c1cnc2ccccc2c1-c1ccccc1.O=C1NC(=O)c2ccccc21>>CC(c1cnc2ccccc2c1-c1ccccc1)N1C(=O)c2ccccc2C1=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05252578,CCCI.COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2>>CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150011533A1,CNCCOC.O=Cc1ccc(-c2cnc3[nH]cc(NC(=O)c4cnn(Cc5ccccc5)c4)c3c2)cc1>>COCCN(C)Cc1ccc(-c2cnc3[nH]cc(NC(=O)c4cnn(Cc5ccccc5)c4)c3c2)cc1,,CN(C)C=O,,CC(=O)O,,val
US20130116245A1,CC(C)(C)NC(=O)c1cc2c(s1)CCCC2.CN(C)C=O.NN>>CC(C)(C)NC(=O)c1sc2c(c1CN=N)CCCC2,,C1CCOC1,,O,[Li]CCCC,val
US03984548,CCOC=C(C(=O)OCC)C(=O)OCC.Cc1ccc2c(c1)OCC(C)N2>>CCOC(=O)c1cn2c3c(cc(C)cc3c1=O)OCC2C,,O,,[Na+].[OH-],,val
US20140228579A1,CC(C)(C)C(=O)Cl.NCc1ccccc1>>CC(C)(C)C(=O)NCc1ccccc1,,ClCCl,,,,val
US04125726,CN.COC(=O)c1nc(SC)n2c1CN=C(c1ccccc1Cl)c1cc(Cl)ccc1-2>>CNC(=O)c1nc(SC)n2c1CN=C(c1ccccc1Cl)c1cc(Cl)ccc1-2,,CCO,,[Br-].[K+],,val
US20020119260A1,CCC[C@@H]1CC[C@@H]([C@H]2CC[C@H](C=O)CC2)CC1.CCOC(=O)CP(CC)CC>>CCC[C@@H]1CC[C@@H]([C@H]2CC[C@H](C=CC(=O)OCC)CC2)CC1,,C1CCOC1,O,[H][H],[H-].[Na+],val
US20050085483A1,CCOC(CN)OCC.CCOC(O)C(F)(F)F>>CCOC(CNCC(F)(F)F)OCC,,CO,Cc1ccccc1,[Na+].[OH-],,val
US20150111734A1,CCN(C(=O)C(C)O)c1cn(-c2cccnc2)nc1Cl.CN(C)C(=O)Cl>>CCN(C(=O)C(C)OC(=O)N(C)C)c1cn(-c2cccnc2)nc1Cl,,ClCCl,,,,val
US20040038855A1,CC(=O)c1cccc(O[C@H](CCCl)c2ccccc2)c1.CC(C)C(=O)Nc1cccc(C2CCNCC2)c1>>CC(=O)c1cccc(O[C@H](CCN2CCC(c3cccc(NC(=O)C(C)C)c3)CC2)c2ccccc2)c1,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20060040968A1,C=CCOC(=O)Cl.CC(C)(C)NCc1cccc(-c2ccnc(Cl)n2)c1>>C=CCOC(=O)N(Cc1cccc(-c2ccnc(Cl)n2)c1)C(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120101134A1,CC(C)(C)OC(=O)CCc1cccc(C(=N)NO)c1.CC(C)Oc1ccc(C(=O)Cl)cc1Cl>>CC(C)Oc1ccc(-c2nc(-c3cccc(CCC(=O)OC(C)(C)C)c3)no2)cc1Cl,,CN(C)C=O,,CCN(CC)CC,,val
US20070123493A1,CCOC(=O)c1ccc(OC)c(C(=O)[O-])c1.Nc1ccc(Cl)cc1>>CCOC(=O)c1ccc(OC)c(C(=O)Nc2ccc(Cl)cc2)c1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US05721245,CC(=O)OCCC1CCn2c(c(C3=C(c4cn(C)c5ccccc45)C(=O)OC3=O)c3ccccc32)C1.CS(=O)(=O)OS(C)(=O)=O.c1ccncc1>>Cn1cc(C2=C(c3c4n(c5ccccc35)CCC(CCOS(C)(=O)=O)C4)C(=O)NC2=O)c2ccccc21,,ClCCl,,,,val
US20080051405A1,CC(C)(C)OC(=O)N1CCCC[C@H]1COc1cccc(COS(C)(=O)=O)n1.COc1ccc(-c2cc3cn[nH]c(=O)c3s2)cc1>>COc1ccc(-c2cc3cnn(Cc4cccc(OC[C@@H]5CCCCN5C(=O)OC(C)(C)C)n4)c(=O)c3s2)cc1,,CN(C)C=O,ClCCl,O,[H-].[Na+],val
US20120010415A1,COc1cc(C(C)=O)ccc1OCC1(NC(=O)OCc2ccccc2)CC1.O=[N+]([O-])O>>COc1cc(C(C)=O)c([N+](=O)[O-])cc1OCC1(NC(=O)OCc2ccccc2)CC1,,CC(=O)OC(C)=O,,,,val
US20130072535A1,CON.O=C(CF)CCc1ccc(Cl)cc1>>CON=C(CF)CCc1ccc(Cl)cc1,,CO,Cl,c1ccncc1,,val
US20160122318A1,CC(C)[C@H](N[S@@](=O)C(C)(C)C)c1ccc(Cl)cc1C(=O)O.Cl>>CC(C)[C@H](N)c1ccc(Cl)cc1C(=O)O.Cl,,ClCCl,,CO,,val
US20110104109A1,Cc1cc2c3c4cccnc4oc(=O)c3n(Cc3cc(C#N)ccc3F)c2cc1F>>Cc1cc2c(cc1F)[nH]c1c(=O)oc3ncccc3c12,O=S(=O)(O)O,CC(=O)O,,,,val
US20140275537A1,CC1(C)O[C@@H](C=C(I)I)[C@@H](C(O)COC(c2ccccc2)(c2ccccc2)c2ccccc2)O1>>CC1(C)O[C@@H](C=C(I)I)[C@@H](C(=O)COC(c2ccccc2)(c2ccccc2)c2ccccc2)O1,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20150045349A1,O=P(Cl)(Cl)Cl.O=c1cc(O)ncn1C1CCOCC1>>O=c1cc(Cl)ncn1C1CCOCC1,,O,,O=C([O-])O.[Na+],,val
US20150210685A1,C[Si](C)(C)CCOCn1c(S(C)(=O)=O)nc2nc(-c3ccc(Br)cc3)c(Cl)cc21.O[C@H]1CO[C@@H]2COC(c3ccccc3)O[C@H]2C1>>C[Si](C)(C)CCOCn1c(O[C@H]2CO[C@@H]3COC(c4ccccc4)O[C@H]3C2)nc2nc(-c3ccc(Br)cc3)c(Cl)cc21,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030109523A1,COC(=O)CC1Cc2ccc(OC)cc2NC1=O>>COC(=O)CC1Cc2ccc(O)cc2NC1=O,,ClCCl,,BrB(Br)Br,,val
US20070232642A1,C=CCCC(C#N)(Cc1cc(Oc2ccccc2)ccc1[N+](=O)[O-])C(=O)OCC>>C=CCCC(C#N)(Cc1cc(Oc2ccccc2)ccc1[N+](=O)[O-])C(=O)O,,CO,O,Cl,[Li+].[OH-],val
US20090264448A1,COc1ccc(C(=O)C=CN(C)C)cc1N(C)C(C)=O.Nc1[nH]ncc1C(=O)c1cccs1>>COc1ccc(-c2ccnc3c(C(=O)c4cccs4)cnn23)cc1N(C)C(C)=O,,CC(=O)O,,CCOC(C)=O,,val
US20080249093A1,CCOC(=O)CCc1ccc(N2CSC(c3ccc(OC(C)C)c(C#N)c3)=N2)c(C)c1>>CCOC(=O)CCc1ccc(N2CSC(c3ccc(O)c(C#N)c3)=N2)c(C)c1,,ClCCl,,ClB(Cl)Cl,,val
US04684652,CCNC(C)CC.O=C(O)c1cc(-c2ccccc2Cl)nc2ccccc12>>CCC(C)N(CC)C(=O)c1cc(-c2ccccc2Cl)nc2ccccc12,,O=S(Cl)Cl,,,,val
US20030195354A1,COc1cc(CCNC(=O)C(=CO)c2ccc(C)cc2)ccc1OCc1ccccc1>>COc1cc(CCNC(=O)C(=CO)c2ccc(C)cc2)ccc1O,,CC(=O)O,,Br,,val
US06011174,CC(C)N(C(=N)OC(C)(C)C)C(C)C.O=C(O)[C@H](Br)CO>>CC(C)(C)OC(=O)[C@H](Br)CO,,ClC(Cl)Cl,,,,val
US20030095958A1,CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccc(Cl)c(Cl)c3)ccc2N)CC1.O=C(Cl)c1cccc2ccccc12>>CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccc(Cl)c(Cl)c3)ccc2NC(=O)c2cccc3ccccc23)CC1,,ClCCl,,,,val
US20030065182A1,CCC(N)=CC(=O)OC.O=C1COCC(=O)C1.O=Cc1ccc(F)c(I)c1>>CCC1=C(C(=O)OC)C(c2ccc(F)c(I)c2)C2=C(COCC2=O)N1,,CCO,,,,val
US20040063732A1,CCOC(=O)c1ccc(Nc2nc(Nc3cccc([N+](=O)[O-])c3)nc3[nH]cnc23)cc1>>CCOC(=O)c1ccc(Nc2nc(Nc3cccc(N)c3)nc3[nH]cnc23)cc1,O=[Pt],CCOC(C)=O,CO,[H][H],,val
US20060166977A1,CC(C)(C)OC(=O)NCCC(N)=S.COc1ccc2ncc(Cl)c(C(=O)CBr)c2n1>>COc1ccc2nccc(-c3csc(CCNC(=O)OC(C)(C)C)n3)c2n1,,CCO,,O=C([O-])O.[Na+],,val
US20080004302A1,COc1ccc(CCc2cc(N)n[nH]2)s1.Cc1cc(CNc2nccc(Cl)n2)on1>>COc1ccc(CCc2cc(Nc3ccnc(NCc4cc(C)no4)n3)n[nH]2)s1,,CCO,,,,val
US20150329548A1,C[C@@H]1CC[C@@H](Cn2cc(I)c3nc(C#N)nc(-c4cncc(Cl)c4)c32)CC1.OB(O)c1ccccc1>>C[C@@H]1CC[C@@H](Cn2cc(-c3ccccc3)c3nc(C#N)nc(-c4cncc(Cl)c4)c32)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20090143353A1,CC(=O)OC(C)=O.CNCCNCC(=O)OC(C)(C)C>>CC(=O)N(C)CCNCC(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20020147214A1,Nc1ccc2c(=O)[nH]cnc2c1.[I-]>>O=c1[nH]cnc2cc(I)ccc12,,Cl,O,O=N[O-].[Na+],,val
US20110237582A1,Cc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1>>Cc1ccc2[nH]cc(C3CCNC3)c2c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120101127A1,CC1(C)CC(c2ccccc2N)Nc2ccc(C(F)(F)F)cc21.O=S(=O)(Cl)c1cccc(F)c1>>CC1(C)CC(c2ccccc2NS(=O)(=O)c2cccc(F)c2)Nc2ccc(C(F)(F)F)cc21,,ClCCl,O,c1ccncc1,,val
US20080009530A1,CCCCCS(=O)(=O)NC(=O)/C=C/c1ccc(OCCCOCCOC)cc1Oc1ncc(C(F)(F)F)cc1Cl>>CCCCCS(=O)(=O)NC(=O)CCc1ccc(OCCCOCCOC)cc1Oc1ncc(C(F)(F)F)cc1Cl,,C1CCOC1,CO,,,val
US04939253,CC(C)OC(=O)CCl.C[C@H]1[C@H](NC(=O)OC(C)(C)C)C(=O)N1O>>CC(C)OC(=O)CON1C(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H]1C,,CN(C)C=O,,CCN(CC)CC,,val
US05559230,CNC.O=C(Nc1ccc(C(=O)N2CCC3OC3c3ccccc32)cc1)c1ccccc1Cl>>CN(C)[C@@H]1c2ccccc2N(C(=O)c2ccc(NC(=O)c3ccccc3Cl)cc2)CC[C@H]1O,,CO,,CCN(CC)CC,Cl,val
US06479524B1,Cc1cc(Br)c(C)cc1Br.O=C=O>>Cc1cc(C(=O)O)c(C)cc1Br,,CCCCCC,,Cl,[Li]CCCC,val
US04617307,CCOC(=O)CCCc1c[nH]cn1.C[Si](C)(C)Cl>>C[Si](C)(C)n1cnc(CCCC=O)c1,,C1CCOC1,,[H-].[Na+],,val
US04396622,CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.NCCN1CCCC1>>CC(=O)Nc1ccc(S(=O)(=O)NCC[NH+]2CCCC2)cc1.[Cl-],,O,,,,val
US05374643,Nc1cccc(-c2nnn[nH]2)c1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>O=C(Nc1cccc(-c2nnn[nH]2)c1)Oc1ccc([N+](=O)[O-])cc1,,CC#N,CN(C)C=O,c1ccncc1,,val
US04472412,C=CCBr.CCCCCC(=Cc1ccc(Cl)cc1Cl)CN1CCCC1>>C=CC[N+]1(CC(=Cc2ccc(Cl)cc2Cl)CCCCC)CCCC1.[Br-],,CC(=O)O,,,,val
US20140163035A1,CON=C1COc2cnc(Cl)cc21>>NC1COc2cnc(Cl)cc21,,C1CCOC1,,B,,val
US20100324000A1,C[C@H](Cc1cccc(OCCC23CC4CC(CC(C4)C2)C3)c1)NC[C@H](O)c1ccc(OCc2ccccc2)c(NC=O)c1>>C[C@H](Cc1cccc(OCCC23CC4CC(CC(C4)C2)C3)c1)NC[C@H](O)c1ccc(O)c(NC=O)c1,[Pd],,,,,val
US20050209274A1,CN(C(=O)c1cc(=O)c2ccc(F)cc2o1)C1CCNCC1.O=Cc1ccc2c(c1)OCO2>>CN(C(=O)c1cc(=O)c2ccc(F)cc2o1)C1CCN(Cc2ccc3c(c2)OCO3)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100249119A1,N#CC1(c2cccc(C(=O)Nc3cc(O)c(F)cc3F)c2Cl)CC1.O=[N+]([O-])c1ccc(Cl)nc1>>N#CC1(c2cccc(C(=O)Nc3cc(Oc4ccc([N+](=O)[O-])cn4)c(F)cc3F)c2Cl)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US06288082B1,COc1ccc2c(Cl)c(C#N)cnc2c1.Nc1ccc2cn[nH]c2c1>>COc1ccc2c(Nc3ccc4cn[nH]c4c3)c(C#N)cnc2c1,,CCOCCO,,Cl,c1ccncc1,val
US05202327,CCOC(=O)C1=C(C(C)C)NC(c2ccccc2)N=C1c1ccc(F)cc1>>CCOC(=O)c1c(-c2ccc(F)cc2)nc(-c2ccccc2)nc1C(C)C,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20050192287A1,CC1(c2cc([N+](=O)[O-])ccc2F)CO1>>CC(C=O)c1cc([N+](=O)[O-])ccc1F,,CCOCC,,FB(F)F,,val
US20100178291A1,CC(C)(C)OC(=O)NCC(=O)c1cn2c3c(cccc13)CCC2.Cl>>Cl.NCC(=O)c1cn2c3c(cccc13)CCC2,,ClCCl,,,,val
US20110319379A1,CCOC(=O)c1cc(O)c2cn(C)nc2c1.CS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>CCOC(=O)c1cc(Oc2ccc(S(C)(=O)=O)cc2C(F)(F)F)c2cn(C)nc2c1,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05728907,CCCCCCCCCCCCCCCCCCCC(Cl)(CCCCCCCCCC)CCCCCCCCCCCCCC.CCCCCCCC[Al](CCCCCCCC)CCCCCCCC>>CCCCCCCCCCCCCCCCCCCC(CCCCCCCC)(CCCCCCCCCC)CCCCCCCCCCCCCC,,ClCCl,,,,val
US20160145245A1,CN(C(=O)Cc1ccc(Cl)c(Cl)c1)[C@H](CN1CC[C@@H](O)C1)c1cccc(N)c1.N#Cc1ccc(S(=O)(=O)Cl)cc1C(F)(F)F>>CN(C(=O)Cc1ccc(Cl)c(Cl)c1)[C@H](CN1CC[C@@H](O)C1)c1cccc(NS(=O)(=O)c2ccc(C#N)c(C(F)(F)F)c2)c1,,ClCCl,,c1ccncc1,,val
US20090124698A1,CCOC(=O)/C(=C(\CC)c1ccccc1)c1ccc(OCOC)cc1>>CC/C(=C(\C(=O)O)c1ccc(OCOC)cc1)c1ccccc1,,CO,,Cl,[Na+].[OH-],val
US20090143366A1,Fc1ccccc1C1=NCCNc2ccc(Br)cc21.OB(O)c1ccncc1>>Fc1ccccc1C1=NCCNc2ccc(-c3ccncc3)cc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US04933355,CCOC(=O)C(=O)c1csc(N)n1.O=C=Nc1ccc(F)cc1F>>CCOC(=O)C(=O)c1csc(NC(=O)Nc2ccc(F)cc2F)n1,,CN(C)C=O,,,,val
US06022906,CCC(Cc1ccccc1)(C(=O)c1ccc(OC)c(OC)c1)N(C)C.OCCCO>>CCC(Cc1ccccc1)(C(=O)c1ccc(OCCCO)c(OC)c1)N(C)C,,CC(=O)N(C)C,,O,[H-].[Na+],val
US20140323464A1,CN1CCN(c2ccc(Nc3ncc(F)c(NCC4CCCN4)n3)cn2)CC1.N#CCC(=O)O>>CN1CCN(c2ccc(Nc3ncc(F)c(NCC4CCCN4C(=O)CC#N)n3)cn2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070208056A1,CC(C)(C)OC(=O)N1CCC(O)(c2ccc(Cl)cc2CO)CC1>>CC(C)(C)OC(=O)N1CCC2(CC1)OCc1cc(Cl)ccc12,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100204240A1,Cc1nn(C)c(C)c1Oc1cc(Br)cnc1C#N.O=S(=O)(O)O>>Cc1nn(C)c(C)c1Oc1cc(Br)cnc1C(N)=O,,O,,[Na+].[OH-],,val
US20080096874A1,COC(=O)C(=O)Cl.Nc1ccc(C2CCCCC2)cc1>>COC(=O)C(=O)Nc1ccc(C2CCCCC2)cc1,,ClCCl,,O,c1ccncc1,val
US20030199440A1,C1CC2(CCN1)OCCO2.CC(C)S(=O)(=O)Cl>>CC(C)S(=O)(=O)N1CCC2(CC1)OCCO2,,ClCCl,,CCN(CC)CC,,val
US08318760B2,CC(c1ccc(C(=O)[O-])cc1)C(CO)c1cccc(-c2ccc(OC(F)(F)F)cc2)c1.ClCCl>>COC(=O)c1ccc(C(C)C(C=O)c2cccc(-c3ccc(OC(F)(F)F)cc3)c2)cc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20080027099A1,CCOC(=O)CCCCCBr.COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c2c1O>>CCOC(=O)CCCCCOc1c(OC)ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c12,,CS(C)=O,,[H-].[Na+],,val
US20090298815A1,CCOC(=O)c1ccc(F)c(NS(=O)(=O)c2c(F)cccc2F)c1.Cc1ccnc(Cl)n1>>O=C(Cc1ccnc(Cl)n1)c1ccc(F)c(NS(=O)(=O)c2c(F)cccc2F)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20030087925A1,CCN(CC)CC.CO.COc1cc2c(cc1C=O)N(C)C(=O)C(C)(C)C2.Cc1ccccc1.N[C@H]1CCCN[C@H]1c1ccccc1>>CCOC(C)=O.CO.[NH4+].[OH-],,Cc1ccccc1,,Cl,Cl,val
US20040097498A1,CCCOc1ccc(N)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1.O=S(=O)(Cl)c1cc(Cl)sc1Cl>>CCCOc1ccc(NS(=O)(=O)c2cc(Cl)sc2Cl)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1,,C1CCOC1,,c1ccncc1,,val
US20050171087A1,CCOC(=O)CN[C@@H]1CCCN2c3cc(Cl)ccc3N(C)c3ccccc3[C@H]12>>CN1c2ccccc2[C@@H]2[C@H](NCC(=O)O)CCCN2c2cc(Cl)ccc21,,C1COCCO1,O,[Na+].[OH-],,val
US20030149019A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCNc1cc(N2CCNCC2)ccc1[N+](=O)[O-]>>CCNc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1[N+](=O)[O-],,C1CCOC1,O,Cl,[Na+].[OH-],val
US20120132870A1,CC(C)(C)c1ccc(C(=O)Cl)cc1.COc1ccccc1OC>>COc1ccc(C(=O)c2ccc(C(C)(C)C)cc2)cc1OC,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20110165183A1,C[C@@H]1CCN(Cc2ccccc2)C[C@@H]1N(C)C(=O)OC(C)(C)C>>C[C@@H]1CCNC[C@@H]1NC(=O)OC(C)(C)C,[Pd],CCO,,O,,val
US04004912,C#CCNCCC=O.O=C=Nc1nnc(C2CC2)s1>>C#CCN(CCC=O)C(=O)Nc1nnc(C2CC2)s1,,c1ccccc1,,,,val
US20080045521A1,CC(C)(C)OC(=O)[C@@H](N)Cc1cc(Br)cs1.O=C(O)c1c(Cl)cccc1Cl>>CC(C)(C)OC(=O)[C@H](Cc1cc(Br)cs1)NC(=O)c1c(Cl)cccc1Cl,,ClCCl,,,,val
US20160244410A1,Cn1c(=O)c2c(O)cc(=O)n(C)c2n(-c2ccc(I)cc2F)c1=O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cn1c(=O)c2c(OS(=O)(=O)C(F)(F)F)cc(=O)n(C)c2n(-c2ccc(I)cc2F)c1=O,,ClCCl,,CCN(CC)CC,,val
US05041462,COc1cccc(NC(=O)COC(C)=O)c1C#N>>COc1cccc(NC(=O)CO)c1C#N,,CO,,N,,val
US20120196845A1,CCOC(=O)c1cn(Cc2ccc(-c3ccccc3)cc2)c2ccccc2c1=S.NN>>O=c1[nH]nc2c3ccccc3n(Cc3ccc(-c4ccccc4)cc3)cc1-2,,CCO,,,,val
US20120149736A1,CC(C)(N)C(=O)O.CC1CCC(O)C1>>CC1CCC(OC(=O)C(C)(C)N)C1,,C1CCCCC1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04409236,COC(=O)c1ccc(CN2CC2C#N)s1>>N#CC1CN1Cc1ccc(C(=O)O)s1,,CC(C)=O,,[Na+].[OH-],,val
US20120225862A1,CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCCc1ccc(S(=O)(=O)NCc2ccc(C(=O)Nc3cccnc3)cc2)cc1>>NCCOCCOCCOCCOCCOCCOCCCc1ccc(S(=O)(=O)NCc2ccc(C(=O)Nc3cccnc3)cc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110294788A1,BrCCCOCc1ccccc1.O=S(=O)(NC1CCCC1)c1ccc(Cl)nc1>>O=S(=O)(c1ccc(Cl)nc1)N(CCCOCc1ccccc1)C1CCCC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20160024009A1,COC(=O)[C@@H](N)CO.O=S(=O)(Cl)c1ccc(Cl)s1>>COC(=O)[C@H](CO)NS(=O)(=O)c1ccc(Cl)s1,,ClCCl,,Cl,,val
US04863920,O=C(O)c1ncn2c1[C@@H]1CCCN1C(=O)c1c(Br)cccc1-2>>O=C1N=CN2c3cccc(Br)c3CN3CCC[C@H]3C12,,CN(C)C=O,,O,,val
US20130079321A1,CC(C)(C)OC(=O)N1CCC(O)C(N=[N+]=[N-])CC1>>[N-]=[N+]=NC1CCNCCC1O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070167488A1,COc1ccc(C(=O)c2ccc(OC)cc2)cc1.O=C1Cc2ccccc2N1>>COc1ccc(C(=C2C(=O)Nc3ccccc32)c2ccc(OC)cc2)cc1,,C1CCOC1,CC(=O)O,O,[H-].[Na+],val
US20020049201A1,C1CCOC1.O=C1c2ccccc2C(=O)N1O>>O=C1c2ccccc2C(=O)N1OC1CCOC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04772600,NC1CCCC1.O=C(O)Cn1c(-c2ccc(Cl)cc2)nc2cccnc21>>O=C(Cn1c(-c2ccc(Cl)cc2)nc2cccnc21)NC1CCCC1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20090186907A1,CCC(C)Cn1c(-c2c(F)cc(OC)cc2F)c(Cl)nc(-n2cccn2)c1=O>>CCC(C)Cn1c(-c2c(F)cc(O)cc2F)c(Cl)nc(-n2cccn2)c1=O,,ClCCl,,BrB(Br)Br,,val
US20080070928A1,CS(=O)(=O)c1ccc(Oc2cc3nc(-c4cnccn4)[nH]c3cc2C2CCCN2C(=O)C(F)(F)F)cc1>>CS(=O)(=O)c1ccc(Oc2cc3nc(-c4cnccn4)[nH]c3cc2C2CCCN2)cc1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20130331378A1,COC(=O)c1cccc(Cc2c(-c3ccsc3)nn3cc(OC)ccc23)n1>>COc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccsc3)nn2c1,,CO,,Cl,[K+].[OH-],val
US04435404,O=C(/C=C/CBr)N(CCO)C1CCCCC1.O=c1ccc2cc(O)ccc2[nH]1>>O=C(C=CCOc1ccc2[nH]c(=O)ccc2c1)N(CCO)C1CCCCC1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04849436,CC1=CC(=O)OC(C)(C)O1.O=C1c2ccccc2C(=O)N1CO>>CC(=O)CC(=O)OCN1C(=O)c2ccccc2C1=O,,Cc1ccccc1,,,,val
US20100286123A1,CCOC(C)=O.N#Cc1ccc(Br)nc1>>C=Cc1ccc(C#N)cn1,,CCO,O,CCN(CC)CC,ClCCl,val
US05519034,Br.CN1CCc2cc(F)c(O)cc2C1C1(c2ccccc2Cl)CCC1>>Br.CN1CCc2cc(F)c(O)cc2C1C1(c2ccccc2Cl)CCC1,,CC(C)O,,,,val
US20100029678A1,Cc1ncc2c(c1O)COC2c1ccc(Cl)cc1.O=C(Cl)Cl.O=[N+]([O-])OCCCO>>Cc1ncc2c(c1OC(=O)OCCCO[N+](=O)[O-])COC2c1ccc(Cl)cc1,,C1CCOC1,O,CCN(C(C)C)C(C)C,,val
US05250690,FC(F)(Cl)CCl.Nc1ccc(O)cc1>>Nc1ccc(OC(F)(F)CCl)cc1,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20150210635A1,COC(=O)C1(CNS(=O)(=O)c2ccccc2F)CC1>>O=C(O)C1(CNS(=O)(=O)c2ccccc2F)CC1,,C1CCOC1,O,[Li+].[OH-],,val
US20040030137A1,O=C1CNC(=O)C(Cc2ccccc2)N1>>C(=C1CNCCN1)c1ccccc1,,CCOCC,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20120108585A1,ClCc1ccnc2sc(Cl)nc12.OB(O)c1cccc(C(F)(F)F)c1>>FC(F)(F)c1cccc(-c2nc3c(CCl)ccnc3s2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20160083368A1,CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)c1nc(C#CC2(O)CCC2)ccc1Br>>N[C@@H](Cc1cc(F)cc(F)c1)c1nc(C#CC2(O)CCC2)ccc1Br,,ClCCl,,O=C(O)C(F)(F)F,,val
US04504305,CCC(=O)C1=C(O)CC(c2ccc(NC=O)cc2)CC1=O.CCON>>CCON=C(CC)C1=C(O)CC(c2ccc(NC=O)cc2)CC1=O,,CCO,,ClC(Cl)Cl,,val
US20140018393A1,N[C@@H]1CC[C@@H](CN(C(=O)C(F)(F)F)[C@@H]2C[C@H]2c2ccccc2)CC1.O=Cc1ccc(C(=O)O)cc1>>O=C(O)c1ccc(CN[C@@H]2CC[C@@H](CN[C@@H]3C[C@H]3c3ccccc3)CC2)cc1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160194316A1,CCN(c1cc(Cl)cc(C(=O)OC)c1C)[C@@H]1COC[C@H]1O>>CCN(c1cc(Cl)cc(C(=O)O)c1C)[C@@H]1COC[C@H]1O,,CCO,CCO,[Na+].[OH-],,val
US20140194430A1,CNCC(C)O.COc1nccc2oc(-c3cnc4ccc(Cl)nn34)cc12>>COc1nccc2oc(-c3cnc4ccc(N(C)CC(C)O)nn34)cc12,,CCCCO,,,,val
US20030139435A1,CNC(=O)c1ccc(C)c(N)c1.Clc1cc(Cl)ncn1>>CNC(=O)c1ccc(C)c(Nc2cc(Cl)ncn2)c1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20070010670A1,O=C(O)c1ccc(O)c(C(F)(F)F)c1.O=S(Cl)Cl>>O=C(Cl)c1ccc(O)c(C(F)(F)F)c1,CN(C)C=O,Cc1ccccc1,,,,val
US20020156311A1,C=CCOc1cc(OS(=O)(=O)c2ccc(C)cc2)ccc1Br>>C=CCOc1cc(O)ccc1Br,,CCO,O,[K+].[OH-],,val
US04582857,CCc1ccc(Br)cc1.ClCC1CO1>>CCc1ccc(CC2CO2)cc1,,CCOCC,,Cl,[Mg],val
US05104867,CI.COc1ccc(CS[C@@H]2CN[C@H](C(N)=O)C2)cc1>>COc1ccc(CS[C@H]2C[C@@H](C(N)=O)N(C)C2)cc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20040138277A1,CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1cccc(C)c1.Cc1ccc(S(=O)(=O)OCCc2nc(-c3cccc(-c4ccccc4)c3)oc2C)cc1>>Cc1cccc(OC(C)(Cc2ccc(OCCc3nc(-c4cccc(-c5ccccc5)c4)oc3C)cc2)C(=O)O)c1,,CCO,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20060217379A1,O=Cc1c(Cl)ncnc1Cl.OCCO>>Clc1ncnc(Cl)c1C1OCCO1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20040132769A1,CC(=O)Nc1ccc2ccc(C(F)(F)F)cc2c1Cl>>Nc1ccc2ccc(C(F)(F)F)cc2c1Cl,,CCO,,O,O=S(=O)(O)O,val
US20030194722A1,Cc1cn([C@H]2C[C@H](O)[C@@](CN)(CO)O2)c(=O)[nH]c1=O.O=C(O)CNC(=O)C(F)(F)F>>Cc1cn([C@H]2C[C@H](O)[C@](CO)(CNC(=O)CNC(=O)C(F)(F)F)O2)c(=O)[nH]c1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US06831079B1,CCCCI.O=C(c1ccc(-c2cc[nH]n2)cc1)N1Cc2cccn2Cc2ccccc21>>CCCCn1ccc(-c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20100227866A1,C[C@@H](O)C(=O)OC(C)(C)C.O=Cc1cccc(O)c1>>C[C@H](Oc1cccc(C=O)c1)C(=O)OC(C)(C)C,,C1CCOC1,CCOC(C)=O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130005941A1,Cc1nc(CS)c(C=O)s1>>Cc1nc2cscc2s1,,CCO,,CC(=O)O,,val
US20070281933A1,CS(=O)(=O)Nc1cccc(-c2cc(C(N)=O)c3[nH]nc(C4CCNCC4)c3c2)c1.Cc1nc(S(=O)(=O)Cl)cn1C>>Cc1nc(S(=O)(=O)N2CCC(c3n[nH]c4c(C(N)=O)cc(-c5cccc(NS(C)(=O)=O)c5)cc34)CC2)cn1C,CN(C)c1ccncc1,,,CCN(C(C)C)C(C)C,,val
US04638068,CC(C)C(C)(C#N)N1C(=O)C=C(Nc2cc(Cl)ccc2CO)C1=O>>CC(C)C(C)(C#N)N1C(=O)C=C(Nc2cc(Cl)ccc2C=O)C1=O,,CCOCC,ClCCl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20080058304A1,COc1cc(C=O)cc(I)c1OC.NS(=O)(=O)O>>COc1cc(C(=O)O)cc(I)c1OC,,CC#N,O,[Na+].[O-]Cl,,val
US20060094779A1,CCOC(=O)C1Cc2cc(OC)ccc2C1=O.FCCBr>>CCOC(=O)C1(CCF)Cc2cc(OC)ccc2C1=O,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US04436746,Cc1c[nH]c2ccccc12.c1c[nH]cn1>>Cc1c(-n2ccnc2)[nH]c2ccccc12,,C1COCCO1,Cl,BrBr,,val
US06075016,CC(=O)N(c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)c1cc(Cl)cc(Br)c1O>>c1ccc2ocnc2c1,,Cc1ccccc1,,O=P(Cl)(Cl)Cl,,val
US04259338,BrCc1ccccc1.CCN(CC)CC.Cc1oc2c(Br)cc(C(CCOS(C)(=O)=O)CCOS(C)(=O)=O)cc2c1C>>Cc1oc2c(Br)cc(C3CCN(Cc4ccccc4)CC3)cc2c1C,,C1CCOC1,,,,val
US20050049487A1,COc1cc(CCl)cc(OC)c1OC.Cn1ccnc1S>>COc1cc(CSc2nccn2C)cc(OC)c1OC,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130225589A1,CC(=O)O.O=C(O)c1ccccc1Nc1ccccc1>>O=C1CC(=O)N(c2ccccc2)c2ccccc21,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20090105253A1,BrCc1ccccc1.CCNC(=O)c1ccc(N=[N+]=[N-])c(O)c1>>CCNC(=O)c1ccc(N=[N+]=[N-])c(OCc2ccccc2)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080221110A1,CCCCOC(=O)/C=C/c1cc(=O)n(Cc2ccc(OC)cc2)nc1OCc1ccc(OC)cc1>>CCCCOC(=O)CCc1cc(=O)n(Cc2ccc(OC)cc2)[nH]c1=O,[Pd],CCO,,C1COCCO1,,val
US20120171703A1,BrBr.COc1ccc(-c2cnc(N)cn2)cc1>>COc1ccc(-c2cnc(N)c(Br)n2)cc1,,ClC(Cl)Cl,,c1ccncc1,,val
US20030220397A1,CCOC(=O)C=C1CCC1.C[N+](=O)[O-]>>CCOC(=O)CC1(C[N+](=O)[O-])CCC1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05786494,CCOC(=O)CC(=O)OCC.O=Cc1ccccc1>>CCOC(=O)C(=Cc1ccccc1)C(=O)OCC,,Cc1ccccc1,,C1CCNCC1,CC(=O)O,val
US20050187236A1,CCNCC.Nc1cc(Nc2ccc3c(ccn3C(=O)Nc3ccccc3)c2)ccn1.O=C(Cl)Oc1ccccc1>>CCN(CC)C(=O)Nc1cc(Nc2ccc3c(ccn3C(=O)Nc3ccccc3)c2)ccn1,,C1CCOC1,,CCN(CC)CC,,val
US20120129851A1,CN(C)C(=O)c1ccc(N)cc1.O=C=Nc1ccc(Br)cc1>>CN(C)C(=O)c1ccc(NC(=O)Nc2ccc(Br)cc2)cc1,,ClCCl,,,,val
US20090111821A1,CS(=O)(=O)OCc1cc(-c2cccc(Cl)c2)on1.NC1CC1>>Clc1cccc(-c2cc(CNC3CC3)no2)c1,,C1CCOC1,,,,val
US20030187014A1,CO.Cc1nn(-c2ccccn2)c2nc3ccccc3c(Cl)c12>>COc1c2ccccc2nc2c1c(C)nn2-c1ccccn1,,C1CCOC1,,C[O-].[Na+],,val
US20110065736A1,CC(C)(C)OC(=O)N1CCC(CO)CC1.COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1O>>COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05110956,C1=Cc2cc3c(cc2C1)OCO3.OO>>OC1Cc2cc3c(cc2C1)OCO3,,C1CCOC1,CCOC(C)=O,O,[Na+].[OH-],val
US20140031364A1,Cc1onc(-c2cccc(F)c2)c1C(=O)O.Fc1ccc(N2CCNCC2)cc1>>Cc1onc(-c2cccc(F)c2)c1C(=O)N1CCN(c2ccc(F)cc2)CC1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US04393221,CC(=O)O[C@@H]1c2ccccc2[C@H]1OC(C)=O.COC(=O)C1CC2=C(C(=O)C=CC2=O)C2(C1)SCCS2>>COC(=O)C1CC2=C(C(=O)c3cc4ccccc4cc3C2=O)C2(C1)SCCS2,,Cc1ccccc1C,,,,val
US20100093803A1,CC(C)(C)OC(=O)c1ccc(NN)nc1.CCOC(=O)C(=CN(C)C)c1cccnc1>>CC(C)(C)OC(=O)c1ccc(-n2[nH]cc(-c3cccnc3)c2=O)nc1,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080221168A1,Cc1cc(Cl)cc(C(=O)N=S2CCCCC2)c1CC(=O)c1cc(Br)nn1-c1ccccc1Cl.OO>>Cc1cc(Cl)cc(C(=O)N=S2(=O)CCCCC2)c1CC(=O)c1cc(Br)nn1-c1ccccc1Cl,,CC(=O)O,,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20060258714A1,C=CCBr.Cc1cc(Cl)ccc1-c1c(O)cccc1F>>C=CCOc1cccc(F)c1-c1ccc(Cl)cc1C,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100130739A1,CCOC(=O)CN.Clc1cnnc(Cl)c1Cl>>CCOC(=O)CNc1cnnc(Cl)c1Cl,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US06759547B1,CCC(=O)c1cc2c(cc1OCOC)C(C)(C)CCC2(C)C.CCOC(=O)C(F)P(=O)(OCC)OCC>>CCOC(=O)/C(F)=C(/CC)c1cc2c(cc1OCOC)C(C)(C)CCC2(C)C,,C1CCOC1,,[Li]CCCC,,val
US20020013318A1,COc1cnn(Cc2ccccc2)c(=O)c1-c1ccc(F)cc1>>O=c1c(-c2ccc(F)cc2)c(O)cnn1Cc1ccccc1,,CC(=O)O,,Br,,val
US04084951,CCCCOP(=O)(Cl)OCCCC.CCCC[Si](C)(CCO)CCCC>>CCCCOP(=O)(OCCCC)OCC[Si](C)(CCCC)CCCC,,ClC(Cl)(Cl)Cl,,c1ccncc1,,val
US05068334,CI.O=C1CCCc2[nH]c(=O)ccc21>>Cn1c2c(ccc1=O)C(=O)CCC2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04866091,CC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.CS(=O)(=O)Nc1ccc(C=O)cc1Oc1ccc(F)cc1F>>CC(=O)C=Cc1ccc(NS(C)(=O)=O)c(Oc2ccc(F)cc2F)c1,,CS(C)=O,,CCOC(C)=O,,val
US20090137499A1,C1CCOC1.CSc1ccc(Cc2ccc(CO)cc2O)cc1>>OCCCc1ccc(Cc2ccc(CO)cc2O)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080045528A1,CNC(=O)c1cc(Oc2ccc3nc(SC)oc3c2)ccn1.O=C(OO)c1cccc(Cl)c1>>CNC(=O)c1cc(Oc2ccc3nc(S(C)=O)oc3c2)ccn1,,ClCCl,,,,val
US20060287363A1,C[C@H]1CC(=O)CCN1C(=O)OC(C)(C)C.Nc1cccc(NC(=O)c2ccc(F)cc2Cl)c1>>C[C@H]1C[C@@H](Nc2cccc(NC(=O)c3ccc(F)cc3Cl)c2)CCN1C(=O)OC(C)(C)C,,C1CCOC1,CO,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20160214971A1,CS(=O)(=O)NC(=O)c1cc(OC(F)F)c(-c2cnc(F)c(Cl)c2)cc1F.Cc1cc(Cl)cc(Cl)c1O>>Cc1cc(Cl)cc(Cl)c1Oc1ncc(-c2cc(F)c(C(=O)NS(C)(=O)=O)cc2OC(F)F)cc1Cl,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130059849A1,CC1(C)OB(c2ccc3c(c2)CC(=O)N3)OC1(C)C.Cc1cc(C)c(CNC(=O)c2cc(Cl)nc3c2cnn3C(C)C)c(=O)[nH]1>>Cc1cc(C)c(CNC(=O)c2cc(-c3ccc4c(c3)CC(=O)N4)nc3c2cnn3C(C)C)c(=O)[nH]1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CS(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20150329523A1,COCCOCCOCCBr.O=[N+]([O-])c1cc(O)cc(Cl)c1>>COCCOCCOCCOc1cc(Cl)cc([N+](=O)[O-])c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20140121206A1,CC(C)(C)c1cc(N2C[C@@]3(CCC[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)on1.O=C1CCC(=O)N1Cl>>CC(C)(C)c1noc(N2C[C@@]3(CCC[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)c1Cl,,ClC(Cl)Cl,,,,val
US06096750,BrBr.CCCCOC(=O)N1CCC(=O)CC1>>Br.O=C1CCNCC1Br,,ClC(Cl)Cl,,,,val
US04321202,CNC.O=C(Nc1ccccc1)c1ccccc1>>CN(C)C(=Nc1ccccc1)c1ccccc1,,ClCCl,,O=S(Cl)Cl,,val
US20090054402A1,O=C1CCCCC1c1ccccc1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>O=S(=O)(OC1=C(c2ccccc2)CCCC1)C(F)(F)F,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US06013653,CC1(C)C2CC[C@]1(CS(=O)(=O)O)C(=O)C2.Cc1[nH]cnc1CC1CCc2c(C)c3ccccc3n2C1=O>>CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.Cc1[nH]cnc1CC1CCc2c(C)c3ccccc3n2C1=O,,CCO,,O,O,val
US20010031874A1,COc1ccc(C(=O)Nc2ccccc2)cc1N.O=S(=O)(Cl)c1cc(Cl)cc(Cl)c1>>COc1ccc(C(=O)Nc2ccccc2)cc1NS(=O)(=O)c1cc(Cl)cc(Cl)c1,CN(C)c1ccncc1,,,,,val
US20010006969A1,C=CCN.C=CCNc1nc(Cl)nc2ccc([N+](=O)[O-])cc12>>C=CCNc1nc(NCC=C)c2cc([N+](=O)[O-])ccc2n1,,O,,,,val
US20070032494A1,CC(C)c1cc(Cc2c(Cl)cc(CC#N)cc2Cl)n[nH]c1=O.CCOC(C)=O>>CC(C)c1cc(Cc2c(Cl)cc(CC(=O)O)cc2Cl)n[nH]c1=O,,Cl,,,,val
US20130203727A1,CCOC(=O)C=C1C(=O)c2cccc(OC)c2CC1C.O=C1CCC(=O)N1Br>>CCOC(=O)C=C1C(=O)c2cccc(OC)c2C(Br)C1C,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US04837204,CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)CN.CC(C)CCC(=O)Cl>>CC(C)CCC(=O)NC[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20150322073A1,COC[C@H](C)Nc1cc2c(cc1N)C(C)(C)C(=O)N2C.Cc1cc(C(=O)O)cn(C)c1=O>>COC[C@H](C)Nc1cc2c(cc1NC(=O)c1cc(C)c(=O)n(C)c1)C(C)(C)C(=O)N2C,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05686445,Cc1ccccc1CO.O=C(Cl)c1ccc(C(=O)N2Cc3ccccc3Cc3ccccc32)cc1>>Cc1ccccc1COC(=O)c1ccc(C(=O)N2Cc3ccccc3Cc3ccccc32)cc1,,C1CCOC1,,[H-].[Na+],,val
US20080306125A1,COC(=O)c1cc(C)c(-c2ccc(OCc3c(-c4ccccc4OC(F)(F)F)noc3C(C)C)cc2C)s1.NN>>Cc1cc(OCc2c(-c3ccccc3OC(F)(F)F)noc2C(C)C)ccc1-c1sc(C(=O)NN)cc1C,,CCO,,O,,val
US20160251361A1,ClCc1cn2cc(Br)cnc2n1.Oc1ccccc1>>Brc1cnc2nc(COc3ccccc3)cn2c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20120053173A1,Br[Mg]C1CCCCC1.Cc1c(C=O)oc2ccc(C#N)cc12>>Cc1c(C(O)C2CCCCC2)oc2ccc(C#N)cc12,,C1CCOC1,,[Cl-].[NH4+],,val
US20100240656A1,CCOc1cc2c(cc1Br)OCO2.Cn1c(S)nc(C(N)=O)c1N>>CCOc1cc2c(cc1Sc1nc(C(N)=O)c(N)n1C)OCO2,,CCOCC,,,,val
US20070191604A1,COC(=O)C1(N(C)C=O)CCNC1.O=C(CCl)N1CC=C(c2ccc(-c3ncccn3)cc2)CC1>>COC(=O)C1(N(C)C=O)CCN(CC(=O)N2CC=C(c3ccc(-c4ncccn4)cc3)CC2)C1,,C1COCCO1,,CCN(CC)CC,Cl,val
US05041455,CCCCCCOc1nonc1-c1cccnc1.CI>>CCCCCCOc1nonc1-c1ccc[n+](C)c1.[I-],,CC(C)=O,,,,val
US20120101110A1,Cc1ccc(S(=O)(=O)n2cc(CN3CCCC4(CCNCC4)C3=O)c3ccccc32)cc1.Cc1n[nH]c(=O)o1>>CC(=O)NNC(=O)N1CCC2(CCCN(Cc3cn(S(=O)(=O)c4ccc(C)cc4)c4ccccc34)C2=O)CC1,,C1CCOC1,,,,val
US20100298336A1,CCN1CCN(c2ccc(C=O)cn2)CC1>>CCN1CCN(c2ccc(CO)cn2)CC1,,CCO,,[BH4-].[Na+],,val
US20090012069A1,COC(=O)C(C)=O.OCC(CO)Cc1ccc(OCc2ccccc2)cc1>>COC(=O)C1(C)OCC(Cc2ccc(OCc3ccccc3)cc2)CO1,,CC#N,,O=C([O-])O.[Na+],,val
US20020111492A1,CCOC(=O)C1(CCCc2c(F)cnc3ccccc23)CCN(C(=O)OC(C)(C)C)CC1>>CCOC(=O)C1(CCCc2c(F)cnc3ccccc23)CCNCC1,,C1COCCO1,CCOCC,Cl,,val
US20120330012A1,CC(C)(O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cc1ccc(S(=O)(=O)n2ccc3c2ncn2c(Br)nc(C4CCCN(C(=O)OCc5ccccc5)C4)c32)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c2ncn2c(-c4ccc(C(C)(C)O)cc4)nc(C4CCCN(C(=O)OCc5ccccc5)C4)c32)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070197622A1,CCc1cccc(C2CC2)c1C(O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CCc1cccc(C2CC2)c1Cc1c[nH]cn1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20080161566A1,CC1(C)CC(c2ccccc2N2CCN(CC3CC3)CC2)CC(C)(C)C1.O=S(=O)(O)O>>CC1(C)CC(c2ccccc2N2CCN(CC3CC3)CC2)CC(C)(C)C1.O=S(=O)(O)O,,CCOC(C)=O,,CCO,,val
US20120028973A1,COC(=O)c1ccc(/C=C/c2ccc(OC(F)(F)F)cc2)cc1>>OCc1ccc(/C=C/c2ccc(OC(F)(F)F)cc2)cc1,,CCOCC,,,,val
US20110275797A1,CCN(C(=O)OC(C)(C)C)c1ccccc1-c1ccc(C(=O)OC)c([N+](=O)[O-])c1>>CCNc1ccccc1-c1ccc(C(=O)OC)c([N+](=O)[O-])c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05317025,CC(=O)CCl.CN1CCC(S)CC1>>CC(=O)CSC1CCN(C)CC1,,C1CCOC1,,C[O-].[Na+],,val
US20140100231A1,COc1nnc(-c2ccccc2)cc1Cn1cnc(C(F)(F)F)c(Oc2cc(Cl)cc(C#N)c2)c1=O>>N#Cc1cc(Cl)cc(Oc2c(C(F)(F)F)ncn(Cc3cc(-c4ccccc4)n[nH]c3=O)c2=O)c1,,CC#N,,C[Si](C)(C)Cl,,val
US20060160832A1,C[Si](C)(C)CCOCn1c(-c2ccc(OCc3ccccc3)cc2)cc2c(Oc3ccc(N)c(Cl)c3)ncnc21.NC1CC1.O=C(Cl)Oc1ccccc1>>C[Si](C)(C)CCOCn1c(-c2ccc(OCc3ccccc3)cc2)cc2c(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)ncnc21,,CN(C)C=O,O,c1ccncc1,,val
US20040157886A1,Cl.O=C(CN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc2[nH]c(=O)oc2c1>>Cl.O=C(CN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc2[nH]c(=O)oc2c1,,CCOC(C)=O,CCOCC,,,val
US05721234,BrBr.CC(=O)Nc1ccc2c(c1)CCC2CCC(=O)O>>CC(=O)Nc1cc2c(cc1Br)C(CCC(=O)O)CC2,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20110212103A1,CC(C)Oc1cc(F)ccc1N.COC(=O)c1sc2ncnc(Cl)c2c1C>>COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C,,C1COCCO1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20130090323A1,Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Cl.Nc1cc(N2CCOCC2)ncc1I>>Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)ncc1I,,COCCOC,,O,[H-].[Na+],val
US20110118246A1,CS(=O)(=O)c1cccnc1C(=O)O.Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12>>CS(=O)(=O)c1cccnc1C(=O)Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080312226A1,CC(C)(C)OC(=O)N1CCNCC1.Clc1ccc(-c2csc(Br)n2)c(Cl)c1>>CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccc(Cl)cc3Cl)cs2)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100137281A1,CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3F)c2s1.COc1ccc(C(=O)CBr)cc1F>>CCc1cc2c(=O)n(CC(=O)c3ccc(OC)c(F)c3)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3F)c2s1,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20160272585A1,COC(=O)[C@H]1CC2(CCN1C(=O)OC(C)(C)C)CC2>>CC(C)(C)OC(=O)N1CCC2(CC2)C[C@@H]1C(=O)O,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20090186879A1,CCC(CC)c1ccc(Cl)c2nc(Cl)n(CCO)c12.O=C1NC(=O)c2ccccc21>>CCC(CC)c1ccc(Cl)c2nc3n(c12)CCN3,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05071844,CS(=O)(=O)Cl.OCCc1ccncn1>>CS(=O)(=O)OCCc1ccncn1,,ClCCl,,CCN(CC)CC,,val
US20120208817A1,CCOC(=O)c1ccc(C=O)cc1OCC.NC(N)=O.O=C(Cc1ccccc1)c1ccccc1>>CCOC(=O)c1ccc(C2NC(=O)NC(c3ccccc3)=C2c2ccccc2)cc1OCC,,CCO,,Cl,,val
US20090118499A1,CC(=O)OC(C)=O.NCC1CC(c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(N)nccn23)C1>>CC(=O)NC[C@@H]1C[C@H](c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(N)nccn23)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20010039344A1,CCOC(=O)c1csc(NC(=O)C(CC2CCCC2)c2ccc(Cl)c(Cl)c2)n1>>O=C(Nc1nc(CO)cs1)C(CC1CCCC1)c1ccc(Cl)c(Cl)c1,,C1CCOC1,,[BH4-].[Na+],,val
US20160194302A1,CCCCCCCCOC(=O)Cn1ccnc1CCC(=O)N1CCC(N(C)C)CC1.Cl>>CCCCCCCCOC(=O)Cn1ccnc1CCC(=O)N1CCC(N(C)C)CC1.Cl,,CCOCC,,,,val
US20130338133A1,CS(=O)(=O)CCN.Cc1cc(-c2cnc3c(S(C)(=O)=O)cc(Br)nn23)ccc1C(=O)NC1CC1>>Cc1cc(-c2cnc3c(NCCS(C)(=O)=O)cc(Br)nn23)ccc1C(=O)NC1CC1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20150218150A1,CN1Cc2cc(-c3ccc(I)s3)ccc2C1=O.Nc1cccc(B(O)O)c1>>CN1Cc2cc(-c3ccc(-c4cccc(N)c4)s3)ccc2C1=O,,CO,ClCCl,,,val
US04329353,CCOC(=O)N1CCC2(CC1)C(=O)NCN2c1ccc(F)cc1.CI>>CCOC(=O)N1CCC2(CC1)C(=O)N(C)CN2c1ccc(F)cc1,,c1ccccc1,,CS(C)=O,[H-].[Na+],val
US20070244131A1,CCCCOB(OCCCC)OCCCC.O=C(O)C1(c2cccc(Br)c2)CCCC1>>O=C(O)C1(c2cccc(B(O)O)c2)CCCC1,,C1CCOC1,O,Cl,[Li]CCCC,val
US06498165B1,CCCc1cc(Cl)nc(SCC)n1.c1ccc2[nH]cnc2c1>>CCCc1cc(-n2cnc3ccccc32)nc(SCC)n1,,CN(C)C=O,,[H-].[Na+],,val
US20090012077A1,N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCc3[nH]c4c(OCc5ccccc5)cccc4c3C2)CC1>>N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCc3[nH]c4c(O)cccc4c3C2)CC1,[Pd],CCOC(C)=O,,,,val
US20080004275A1,CCOC(=O)c1nc([N+](=O)[O-])cn1CC1CC1>>CCOC(=O)c1nc(N)cn1CC1CC1,[Ni],C1CCOC1,,[H][H],,val
US20130059808A1,CC(C)(C)OC(=O)N[C@@H](CCCN)C(=O)O.O=C1OC(=O)c2ccccc21>>CC(C)(C)OC(=O)N[C@@H](CCCN1C(=O)c2ccccc2C1=O)C(=O)O,,CN(C)C=O,,,,val
US20070010573A1,NC1CCCCC1.O=S1(=O)CCCCO1>>O=S(=O)(O)CCCCNC1CCCCC1,,C1COCCO1,,,,val
US20030069239A1,Cl.FC(F)(F)c1cc(Cl)nc(-c2cccnc2)n1.Nc1cccc(O)c1>>Cl.Oc1cccc(Nc2cc(C(F)(F)F)nc(-c3cccnc3)n2)c1,,CCO,O,,,val
US20080058339A1,CS(=O)(=O)c1ccc(B(O)O)cc1.Cc1ccc(Cl)nn1>>Cc1ccc(-c2ccc(S(C)(=O)=O)cc2)nn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20080161280A1,CC(C)(C)OC(=O)N1CCC1C(=O)Nc1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1.O=C(O)C(F)(F)F>>O=C(Nc1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)C1CCN1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20100190761A1,CC(C)C(C)(c1ccc(OCc2ccccn2)cc1)c1ccc(-c2ccc(F)nc2)cc1.O[C@H]1CCNC1>>CC(C)C(C)(c1ccc(OCc2ccccn2)cc1)c1ccc(-c2ccc(N3CC[C@H](O)C3)nc2)cc1,,CCOC(C)=O,CN1CCCC1=O,,,val
US20050009878A1,CCOC(=O)c1nc(C)n(C2CC2)c1C>>Cc1nc(CO)c(C)n1C1CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160009720A1,CC(C)(C)OC(=O)N1CCC[C@@H](COc2nc(-c3ccc(C#N)cc3)c(Cl)n3ccnc23)C1>>N#Cc1ccc(-c2nc(OC[C@@H]3CCCNC3)c3nccn3c2Cl)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110166135A1,CN(C)c1nc(/C=C/c2nc(C=O)cc(N3CCCC3)n2)nc2ccccc12.NC1CC1>>CN(C)c1nc(/C=C/c2nc(CNC3CC3)cc(N3CCCC3)n2)nc2ccccc12,,ClCCl,,O=C([O-])O.[Na+],,val
US20120122884A1,COC(=O)c1nc(-c2ccc(S(C)(=O)=O)cc2)cnc1N>>CS(=O)(=O)c1ccc(-c2cnc(N)c(C(=O)O)n2)cc1,,CO,O,Cl,[Li+].[OH-],val
US20100076014A1,Fc1ccc(-n2ncc3cc(I)ccc32)cc1.O=C1CCCCC1>>OC1(c2ccc3c(cnn3-c3ccc(F)cc3)c2)CCCCC1,,C1CCOC1,,[Li]CCCC,,val
US20100022555A1,CNC.O=C(c1ccc(Cl)nc1)N1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1>>CN(C)c1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc(C(F)(F)F)cc3)CC2)cn1,,CCOC(C)=O,,,,val
US20070173506A1,CC(C)(C)OC(=O)N[C@H](c1ccc(C(F)(F)F)cc1)[C@@H](O)CO.CC(C)(C)[Si](C)(C)Cl>>CC(C)(C)OC(=O)N[C@H](c1ccc(C(F)(F)F)cc1)[C@@H](O)CO[Si](C)(C)C(C)(C)C,,CN(C)C=O,,c1c[nH]cn1,,val
US20060258722A1,CCOC(=O)C(C(=O)OCC)C1CCCc2nc(SCc3cccc(Oc4ccccc4)c3)sc21>>O=C(O)CC1CCCc2nc(SCc3cccc(Oc4ccccc4)c3)sc21,,CC(=O)O,,Cl,,val
US20060167248A1,Nc1c(Br)cc([N+](=O)[O-])cc1C(F)(F)F>>Nc1cc(Br)c(N)c(C(F)(F)F)c1,[Zn],C1CCOC1,,Cl,,val
US20080287638A1,CCCCCCC(CCCCCN=C=O)N=C=O.CCCCCCN.O=C=NCCCCCCCCCCCCN=C=O>>CCCCCCNC(=O)NCCCCCCCCCCCCNC(=O)NCCCCCC,,Clc1ccccc1Cl,,,,val
US20130045986A1,CC(C)(C)OC(=O)N1CC=C(c2ccc3nc(-c4ccc(C(F)F)cc4)oc3c2)CC1>>Cc1ccc(-c2nc3ccc(C4CCN(C(=O)OC(C)(C)C)CC4)cc3o2)cc1,[Pd],CO,,,,val
US20140121198A1,CCOC([O-])[O-].Nc1cnc2ccsc2c1NC1(CO)CCC2(CC1)OCCO2>>OCC1(n2cnc3cnc4ccsc4c32)CCC2(CC1)OCCO2,,CCOC(C)=O,Cc1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140051676A1,COCCBr.Nc1nc(Nc2ccccc2)nc(-c2noc(-c3ccc(OCC(F)(F)F)nc3)n2)n1>>COCCN(c1ccccc1)c1nc(N)nc(-c2noc(-c3ccc(OCC(F)(F)F)nc3)n2)n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090124609A1,COCC(=O)Cl.Nc1cnc2c(Cl)ccnc2c1>>COCC(=O)Nc1cnc2c(Cl)ccnc2c1,,ClCCl,,CCN(CC)CC,,val
US05637770,CCOC(=O)C(F)(F)F.Cc1c(F)cc(N)c2c1CCC(N)C2=O>>Cc1c(F)cc(N)c2c1CCC(NC(=O)C(F)(F)F)C2=O,,C1CCOC1,CCN(CC)CC,CCO,Cl,val
US20090163471A1,COC(=O)c1cc(C)c(C(=O)OC)c([N+](=O)[O-])c1C>>COC(=O)c1c(C)cc(C(=O)O)c(C)c1[N+](=O)[O-],,C1COCCO1,O,[Na+].[OH-],,val
US05705499,CCN1c2ncc(C=O)cc2C(=O)N(C)c2ccc(Cl)nc21.Nc1ccccc1>>CCN1c2ncc(CNc3ccccc3)cc2C(=O)N(C)c2ccc(Cl)nc21,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20040082574A1,O=C(OC[C@H]1O[C@@H](n2cc([N+](=O)[O-])ccc2=O)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1)c1ccccc1>>O=c1ccc([N+](=O)[O-])cn1C1OC(CO)C(O)C1O,,N,,,,val
US04514044,O=C(O)[C@@H]1CC[C@@H](c2ccc(Cl)cc2)CC1.O=S(Cl)Cl>>O=C(Cl)[C@@H]1CC[C@@H](c2ccc(Cl)cc2)CC1,,ClC(Cl)(Cl)Cl,,,,val
US20100204196A1,COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2cc(F)cc(F)c2C(N)=O)c2ccn(S(=O)(=O)c3ccc(C)cc3)c2n1>>COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2cc(F)cc(F)c2C(N)=O)c2ccnc-2[nH]1,,C1COCCO1,CCOC(C)=O,[Na+].[OH-],,val
US06130239,C#C[C@@H](O)CCCCC.COc1cc[nH]c1/C=C1\C(=O)Nc2cccc(I)c21>>CCCCC[C@H](O)C#Cc1cccc2c1/C(=C/c1[nH]ccc1OC)C(=O)N2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCN(CC)CC,CN(C)C=O,,,val
US20160159808A1,CC(C)(O)[C@@H](NC(=O)c1cnn2ccc(Cl)nc12)c1ccc(OC(F)(F)F)cc1.c1c[nH]nn1>>CC(C)(O)[C@@H](NC(=O)c1cnn2ccc(-n3ccnn3)nc12)c1ccc(OC(F)(F)F)cc1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150274767A1,Cc1ccc(C(=O)OC[C@H]2O[C@@H](n3ccc4c(Cl)nc(Cl)nc43)C[C@@H]2OC(=O)c2ccc(C)cc2)cc1.N>>Nc1nc(Cl)nc2c1ccn2[C@H]1C[C@H](O)[C@@H](CO)O1,,CC(=O)O,,,,val
US20100076014A1,CCOC(=O)/C=C/c1cc2cnn(-c3ccc(F)cc3)c2cc1C>>Cc1cc2c(cnn2-c2ccc(F)cc2)cc1CCC(=O)O,[Pd],CCO,,,,val
US20070032485A1,CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(NCC(C)C(=O)OC(C)(C)C)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC>>CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(NCC(C)C(=O)O)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC,,CCOC(C)=O,Cl,,,val
US20140135336A1,CC(C)(C)OC(=O)N1CCC(Nc2cc(Cl)nnc2Cl)CC1.NN>>CC(C)(C)OC(=O)N1CCC(Nc2cc(Cl)nnc2NN)CC1,,CCO,,O,,val
US20060287327A1,BrC(Br)(Br)Br.N#Cc1ccc(N2CCN(CCO)CC2)cc1C(F)(F)F>>N#Cc1ccc(N2CCN(CCBr)CC2)cc1C(F)(F)F,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])[O-].[K+].[K+],val
US03974154,CC(C)(C)OC(=O)C(Cl)N1C(=O)C(NC(c2ccccc2)(c2ccccc2)c2ccccc2)C1SCC#CCc1ccccc1.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)C(Cl)N1C(=O)C(NC(c2ccccc2)(c2ccccc2)c2ccccc2)C1S(=O)CC#CCc1ccccc1,,CCO,,,,val
US20040229903A1,BrC(Br)(Br)Br.CCOC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(CO)cc3)ccn2c1=O>>CCOC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(CBr)cc3)ccn2c1=O,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120178748A1,COC(=O)CC(C)C(=O)O.O=C(Cl)C(=O)Cl>>COC(=O)CC(C)C(=O)Cl,,ClCCl,,CN(C)C=O,,val
US04999436,CC(=O)OC(C)=O.CCOC(=S)C1CCCCC1(Cc1ccc(OC)cc1)Cc1ccc(OC)cc1>>COc1ccc(-c2sc3c(c2OC(C)=O)CCCC3)cc1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20030069434A1,CN(CC=C(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)CCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)C(=O)CC[C@H]3[C@H]12>>CN(CC=C(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)CCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)C(O)CC[C@H]3[C@H]12,,CO,,[BH4-].[Na+],,val
US05389633,CCOC(=O)C(C)(C)CCCS(N)(=O)=O>>CC(C)(CO)CCCS(N)(=O)=O,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20100190824A1,COc1ccc(CC2NCCC(=O)C2(C)C)cc1.O=Cc1ccccn1>>COc1ccc(CC2NCC(=Cc3ccccn3)C(=O)C2(C)C)cc1,,C1CCOC1,O,Cl,CC(C)(C)[O-].[K+],val
US20060252837A1,CS(=O)(=O)Cl.O=C(N[C@H]1CCCC[C@H]1NC(=O)c1nc2c(s1)CNCC2)c1cc2cc(Cl)ccc2[nH]1>>CS(=O)(=O)N1CCc2nc(C(=O)N[C@@H]3CCCC[C@@H]3NC(=O)c3cc4cc(Cl)ccc4[nH]3)sc2C1,,c1ccncc1,,CCN(CC)CC,Cl,val
US20160002205A1,COc1cc(-c2cnc(N)c(O[C@H](C)c3c(Cl)ccc(F)c3Cl)c2)cnc1C1=CCNCC1>>COc1cc(-c2cnc(N)c(O[C@H](C)c3c(Cl)ccc(F)c3Cl)c2)cnc1C1CCNCC1,[Pd],CO,,,,val
US20120232051A1,COc1cccc(F)c1-c1ccncc1N(CC(F)(F)F)C(=O)c1cc(C(F)(F)F)cc(S(C)(=O)=O)c1.N#CCNc1cnccc1-c1ccccc1OC(F)(F)F>>CS(=O)(=O)c1cc(C(=O)N(CC#N)c2cnccc2-c2ccccc2OC(F)(F)F)cc(C(F)(F)F)c1,,ClCCl,,CCN(C(C)C)C(C)C,[Cl-].[NH4+],val
US20100113462A1,CCOC(=O)C1(N)Cc2ccccc2C1.O=C(O)[C@@H]1CCCc2ccccc21>>CCOC(=O)C1(NC(=O)[C@@H]2CCCc3ccccc32)Cc2ccccc2C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030153596A1,COC(=O)c1cc(C(C)(C)C)ccc1C#N>>CC(C)(C)c1ccc(CN)c(CO)c1,,CCOCC,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20070249579A1,COc1cnc(Cl)c2[nH]cc(C(=O)C(=O)N3CCN(c4nnnn4-c4ccccc4)CC3)c12.C[Sn](C)(C)c1csc(C2OCCO2)n1>>COc1cnc(-c2csc(C3OCCO3)n2)c2[nH]cc(C(=O)C(=O)N3CCN(c4nnnn4-c4ccccc4)CC3)c12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,N#N,,val
US20070249670A1,COC(=O)CS.N#C/C=C(/Cl)c1cccnc1>>COC(=O)c1sc(-c2cccnc2)cc1N,,CN(C)C=O,O,CO,C[O-].[Na+],val
US20110224155A1,CCN.N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-]>>CCNc1cccc([N+](=O)[O-])c1C#N,,C1CCOC1,,,,val
US20120083469A1,C=CCCC(=O)CCCNC(=O)OC(C)(C)C.CC(=O)[O-].C[NH3+].OCC(F)(F)F.[C-]#[N+]C(C)(C)C>>C=CCCC(CCCNC(=O)OC(C)(C)C)(C(=O)NC(C)(C)C)N(C)C(C)=O,,CCOC(C)=O,,Cl,,val
US20110206607A1,Cc1cc(O[Si](C)(C)C(C)(C)C)cc(C)c1-c1nc2cccc(OCCO)n2c1Nc1ccc2c(c1)OCCO2.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCCOc2cccc3nc(-c4c(C)cc(O[Si](C)(C)C(C)(C)C)cc4C)c(Nc4ccc5c(c4)OCCO5)n23)cc1,,ClCCl,,,,val
US20080234301A1,CC[C@H](CC(=O)O)c1ccc(CO)cc1.CO>>CC[C@H](CC(=O)OC)c1ccc(CO)cc1,,O=S(=O)(O)O,,,,val
US04962203,CC(Br)C#N.Oc1cccc(C=Cc2ccc3ccc(Cl)cc3n2)c1>>CC(C#N)Oc1cccc(C=Cc2ccc3ccc(Cl)cc3n2)c1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US03951952,Cl.ClP(Cl)(Cl)(Cl)Cl.N=C(NCC(=O)O)c1ccccc1>>Cl.N=C(NCC(=O)Cl)c1ccccc1,,ClCCl,,,,val
US20030180662A1,C=CC(=O)Cl.CCC(O)(CC)C12CC3CC(CC(O)(C3)C1)C2>>C=CC(=O)OC(CC)(CC)C12CC3CC(CC(O)(C3)C1)C2,,C1COCCO1,,CCN(CC)CC,,val
US20060116410A1,N#Cc1ccc(CNC(=O)c2cccc(Cl)c2)c(NCc2ccc(C(N)=O)cc2)c1.NO>>NC(=O)c1ccc(CNc2cc(C(N)=NO)ccc2CNC(=O)c2cccc(Cl)c2)cc1,,CCN(CC)CC,,Cl,,val
US20130225579A1,ClCc1ccccc1Cl.O=[N+]([O-])c1ccc(O)c(Cl)c1>>O=[N+]([O-])c1ccc(OCc2ccccc2Cl)c(Cl)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06156758,CC(C)(C)OC(=O)c1ccc(NC2CCNCC2)cc1.COc1ccc2nc(Cl)[nH]c2c1>>COc1ccc2[nH]c(N3CCC(Nc4ccc(C(=O)OC(C)(C)C)cc4)CC3)nc2c1,,CCCCCO,,,,val
US20150057271A1,Nc1cncs1.O=S(=O)(Cl)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1Br>>O=S(=O)(Nc1cncs1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1Br,,C1CCOC1,,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20130102576A1,COC(=O)CN1C(=O)C2(OCC(C)(C)CO2)c2cc(NS(C)(=O)=O)ccc21.ClCCN1CCOCC1>>COC(=O)CN1C(=O)C2(OCC(C)(C)CO2)c2cc(N(CCN3CCOCC3)S(C)(=O)=O)ccc21,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090029981A1,COCCCBr.COCCCOc1ccc([C@H]2[C@H](O)CN(C(=O)OCc3ccccc3)C[C@@H]2OCc2ccc3c(c2)N(CCCOC)CCO3)cc1>>COCCCOc1ccc([C@H]2[C@H](OCCCOC)CN(C(=O)OCc3ccccc3)C[C@@H]2OCc2ccc3c(c2)N(CCCOC)CCO3)cc1,,CN(C)C=O,O,[H-].[Na+],,val
US20100041656A1,COC(=O)c1ccc(CN(C(=O)C2CCCc3c(OCc4ccccc4)cccc32)c2ccc(C(C)C)cc2)cc1>>CC(C)c1ccc(N(Cc2ccc(C(=O)O)cc2)C(=O)C2CCCc3c(OCc4ccccc4)cccc32)cc1,,CO,,Cl,[Na+].[OH-],val
US20090227570A1,CN1CCC(OC(=O)Cl)CC1.Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1>>CN1CCC(OC(=O)Nc2ccc3nc(N[C@@H]4CCc5ccccc54)ccc3c2)CC1,,CCN(CC)CC,,Cl,,val
US20140256700A1,C1COCCN1.Cc1noc(C)c1-c1cc(C#N)c2c3ccc(C(=O)O)cc3n(C(c3ccccc3)c3ccccc3)c2c1>>Cc1noc(C)c1-c1cc(C#N)c2c3ccc(C(=O)N4CCOCC4)cc3n(C(c3ccccc3)c3ccccc3)c2c1,,CN(C)C=O,O,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20120022043A1,CN(C)C=C(C(=O)c1cc(Cl)ccc1Cl)N1C(=O)c2ccccc2C1=O.CNN>>Cn1cc(N)c(-c2cc(Cl)ccc2Cl)n1,,CCO,,,,val
US20130331419A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc(F)cc2c1ccn2Cc1ccc(Cl)cc1>>CC(C)(C)OC(=O)Nc1cc(F)cc2c1ccn2Cc1ccc(Cl)cc1,,CC(C)(C)O,,,,val
US20130225602A1,Cn1ccc2ccc(F)nc21.O=C1CCC(=O)N1Br>>Cn1cc(Br)c2ccc(F)nc21,,ClCCl,,,,val
US20040229862A1,COc1ccc(N2CCOCC2)c2sc(C#N)nc12.S>>COc1ccc(N2CCOCC2)c2sc(C(N)=S)nc12,,c1ccncc1,,CCN(CC)CC,,val
US20070179151A1,CC(C)O.COc1ccc2c(Cl)nc(Nc3cc(C)[nH]n3)cc2c1>>COc1ccc2c(OC(C)C)nc(Nc3cc(C)[nH]n3)cc2c1,,CC(C)O,,,,val
US20100093706A1,COC(=O)[C@@H]1CC[C@@H](C)N(C(=O)OC(C)(C)C)C1>>C[C@@H]1CC[C@@H](CO)CN1C(=O)OC(C)(C)C,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20070037802A1,O=[N+]([O-])c1c(CS(=O)(=O)c2cccc3ccccc23)cccc1OCCCCl>>Nc1c(CS(=O)(=O)c2cccc3ccccc23)cccc1OCCCCl,[Pd],C1CCOC1,CO,O=CO,,val
US20090318428A1,N.O=[N+]([O-])c1cnc(Cl)c([N+](=O)[O-])c1>>Nc1ncc([N+](=O)[O-])cc1[N+](=O)[O-],,CCO,,,,val
US20160024077A1,CC(=O)CCl.COC(=O)c1cc(-c2cccc(Br)c2)n[nH]1>>COC(=O)c1cc(-c2cccc(Br)c2)nn1CC(C)=O,,CCOCC,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US20040127574A1,COC(=O)c1cccc2c1C(O)CCC2>>COC(=O)c1cccc2c1C=CCC2,,CO,,Cl,,val
US20150291655A1,CC(C)[C@@H]1CC[C@]2(NCCN3CCS(=O)(=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@@](CF)(C(=O)OCC[Si](C)(C)C)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>CC(C)[C@@H]1CC[C@]2(NCCN3CCS(=O)(=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@@](CF)(C(=O)O)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1COCCO1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20120184587A1,COc1c(C#N)cc(C(=O)O)cc1C1CC1.O=S(Cl)Cl>>COc1c(C#N)cc(C(=O)Cl)cc1C1CC1,,CN(C)C=O,,Cc1ccccc1,,val
US20090062280A1,CC(C)(C)CCBr.CC(C)(C)c1cc2ccccc2[nH]c1=O.CN(C)C=O>>COc1ccc2cc(C(C)(C)C)c(=O)n(CCC(C)(C)C)c2c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05281704,CC(C)(C)OC(=O)NCCNC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)NCCNC(=O)OC(C)(C)C)CC(=O)O)CC(=O)O.O.[OH-]>>NCCNC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)NCCN)CC(=O)O)CC(=O)O.O.O,,O,,Cl,,val
US20140329858A1,CCOC(=O)c1ccc(N2C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)[C@@H]3COCC[C@H]32)cc1C>>Cc1cc(N2C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)[C@@H]3COCC[C@H]32)ccc1C(=O)O,,C1CCOC1,,O,[Li+].[OH-],val
US20130225646A1,CCNC(=O)OCC(CNC(=O)OC(C)(C)C)c1cccc(C(F)(F)F)c1.Cl>>CCNC(=O)OCC(CN)c1cccc(C(F)(F)F)c1.Cl,,C1COCCO1,,,,val
US20140018325A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)OCC>>CCOC(=O)CC[C@@H](C(=O)OCC)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,CN(C)c1ccncc1,CC#N,,,,val
US03979455,C1COCCN1.O=C1CCCCC1>>C1=C(N2CCOCC2)CCCC1,,Cc1ccccc1,,,,val
US20110009405A1,FC(F)c1nc2ccccc2n1-c1nc(Cl)nc(N2CCOCC2)n1.Nc1ccncc1>>FC(F)c1nc2ccccc2n1-c1nc(Nc2ccncc2)nc(N2CCOCC2)n1,,CS(C)=O,,O,,val
US20020156081A1,CC=O.CN1CCN([C@H]2CC[C@@H](n3nc(-c4ccc(N)c(F)c4)c4c(N)ncnc43)CC2)CC1>>CCNc1ccc(-c2nn([C@@H]3CC[C@H](N4CCN(C)CC4)CC3)c3ncnc(N)c23)cc1F,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05612342,COc1cc(C(C)=O)ccc1OCCCl.Clc1ccc2c(C3CCNCC3)noc2c1>>COc1cc(C(C)=O)ccc1OCCN1CCC(c2noc3cc(Cl)ccc23)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100035883A1,CCOC(OCC)c1ccc(CNC)cc1.O=C(Cl)OCc1ccccc1>>CCOC(OCC)c1ccc(CN(C)C(=O)OCc2ccccc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20130244993A1,C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O.OC1(c2ccc(Br)cc2)COC1>>C[C@@H](c1ccc(-c2ccc(C3(O)COC3)cc2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20030109527A1,Nc1ccc(Cl)c(S(N)(=O)=O)c1O.Nc1cccc(F)c1Br.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>NS(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2cccc(F)c2Br)c1O,,CN(C)C=O,Cc1ccccc1,CCN(CC)CC,,val
US05700819,COC(=O)CCCCCCc1nc2c(F)c(F)cc(F)c2s1>>O=C(O)CCCCCCc1nc2c(F)c(F)cc(F)c2s1,,C1COCCO1,O,[Na+].[OH-],,val
US20040048908A1,CCOC(=O)CC(=O)OCC.ClCc1cnoc1-c1cc(Cl)c(Cl)s1>>O=C(O)CCc1cnoc1-c1cc(Cl)c(Cl)s1,,C1CCOC1,O,Cl,[H-].[Na+],val
US20080207639A1,COC(=O)Cc1ccc(-c2ccccc2N)s1.COc1cc(-c2ccccc2C(=O)Cl)cc(OC)c1OC>>COC(=O)Cc1ccc(-c2ccccc2NC(=O)c2ccccc2-c2cc(OC)c(OC)c(OC)c2)s1,,ClCCl,c1ccncc1,,,val
US20090012320A1,CCCCC=O.CCOC(=O)CC(=O)[O-]>>CCCCC=CC(=O)OCC,CN(C)c1ccncc1,CN(C)C=O,,,,val
US20150232435A1,CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.O=C(n1ccnc1)n1ccnc1.c1ccc(N2CCCNCC2)cc1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCCN(c4ccccc4)CC3)CC2)cc(C(F)(F)F)n1,,CO,ClC(Cl)Cl,,,val
US20140037564A1,Nc1cc(C(F)(F)F)ccc1S.O=Cc1cc(O)cc(O)c1>>Oc1cc(O)cc(-c2nc3cc(C(F)(F)F)ccc3s2)c1,,CCOC(C)=O,O,CC(=O)O,CC(=O)[O-].[Na+],val
US20060264428A1,C[C@H](c1ccccc1)N1C[C@@](C)(C(=O)OC(C)(C)C)C(F)C1=O>>C[C@H](c1ccccc1)N1CC(F)[C@](C)(C(=O)OC(C)(C)C)C1,,C1CCOC1,,B,,val
US20060247289A1,CC(C)(C)C(=N)N.O=C(CBr)c1ccc(Br)cc1>>CC(C)(C)c1nc(-c2ccc(Br)cc2)c[nH]1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060041144A1,C#CCOC(C(=O)Cl)c1ccc(Cl)cc1.COc1ccc(-c2ncccc2N)cc1OC>>C#CCOC(C(=O)Nc1cccnc1-c1ccc(OC)c(OC)c1)c1ccc(Cl)cc1,,CCOC(C)=O,,C1CCOC1,CCN(CC)CC,val
US20090264445A1,CCOC(=O)C=C(CN[C@@H](C[C@@H](C)OCC)C(=O)Nc1ccn(CC(C)(C)O)n1)Oc1cccc(Cl)c1Cl>>CCO[C@H](C)C[C@@H](C(=O)Nc1ccn(CC(C)(C)O)n1)N1CC(Oc2cccc(Cl)c2Cl)=CC1=O,,C1CCOC1,,,,val
US20150368208A1,C=CC(=O)Nc1cccc(-c2nc(Nc3ccc(N4CCOCC4)c(O)c3)nc3c2cnn3C2CCCCO2)c1>>C=CC(=O)Nc1cccc(-c2nc(Nc3ccc(N4CCOCC4)c(O)c3)nc3[nH]ncc23)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140228340A1,CC(C)(C)OC(=O)N1CCC(O)CC1.O=[N+]([O-])c1cn[nH]c1>>CC(C)(C)OC(=O)N1CCC(n2cc([N+](=O)[O-])cn2)CC1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150266893A1,COc1ccc(/C=C/C(=O)O)cc1OC.Nc1ccccc1N>>COc1ccc(/C=C/c2nc3ccccc3[nH]2)cc1OC,,O,OCCO,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20100063077A1,Clc1ncc(Br)cn1.Nc1ccc(C(=O)C(F)(F)F)cc1>>O=C(c1ccc(Nc2ncc(Br)cn2)cc1)C(F)(F)F,,CCCCO,,[Cl-].[NH4+],,val
US20130131043A1,CS(=O)(=O)Cl.OC1CCCCCC1>>CS(=O)(=O)OC1CCCCCC1,,ClCCl,c1ccncc1,,,val
US06887890B2,Cc1[nH]c2ccccc2c1CC(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)Nc1ccc(C(c2ccc(NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)Cc3c(C)[nH]c4ccccc34)cc2)c2ccc(NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)Cc3c(C)[nH]c4ccccc34)cc2)cc1>>Cc1[nH]c2ccccc2c1CC(=O)N[C@@H](CCC(=O)O)C(=O)Nc1ccc(C(c2ccc(NC(=O)[C@H](CCC(=O)O)NC(=O)Cc3c(C)[nH]c4ccccc34)cc2)c2ccc(NC(=O)[C@H](CCC(=O)O)NC(=O)Cc3c(C)[nH]c4ccccc34)cc2)cc1,,CO,,O=C(O)C(F)(F)F,,val
US20150018547A1,COc1ccc(CSc2cc(Cl)cc(OC)c2Cl)cc1>>COc1cc(Cl)cc(S)c1Cl,,O,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20040122063A1,BrCc1cscn1.C1COCCN1>>c1nc(CN2CCOCC2)cs1,,CN(C)C=O,,CCN(CC)CC,,val
US20090005353A1,CC(C)(C)N1C(=O)C(Cl)=C(c2ccccc2)S1(=O)=O.NCCCO>>CC(C)(C)N1C(=O)C(NCCCO)=C(c2ccccc2)S1(=O)=O,,CC#N,,,,val
US20090093483A1,C=CCC[Mg]Br.CCOC(=O)C1=C(O)C2(CCOCC2)c2ccc(Cl)cc2C1=O>>C=CCCC(=O)C1=C(O)C2(CCOCC2)c2ccc(Cl)cc2C1=O,,C1CCOC1,,[H-].[Na+],,val
US20160046614A1,CCOC(=O)c1cccc(Sc2c(C3CC3)n(-c3cnn(CCCC(=O)O)c3)c3c(F)c(Cl)ccc23)c1F.O=C1CCC(=O)N1Br>>CCOC(=O)c1cccc(Sc2c(Br)n(-c3cccnc3)c3c(F)c(Cl)ccc23)c1F,,ClCCl,O,,,val
US20080139558A1,CC(=O)c1cccc(Cl)c1.CCOC=O>>O=CCC(=O)c1cccc(Cl)c1,,C1CCOC1,,CO,C[O-].[Na+],val
US20160152614A1,Cc1ccc(S(=O)(=O)n2cc(-c3nc(C)c(F)c(=S=O)[nH]3)c3cc(Cl)cnc32)cc1.N[C@H]1CCCC[C@@H]1N>>Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(N[C@H]4CCCC[C@@H]4N)n3)c3cc(Cl)cnc32)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US03987047,CC(=O)Cl.Clc1c2c(nc3ccccc13)CCCNC2>>CC(=O)N1CCCc2nc3ccccc3c(Cl)c2C1.Cl,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20030060467A1,CC(=O)c1cc(OS(=O)(=O)c2ccc(C)cc2)n[nH]1.NNC(=O)c1ccccc1F>>Cc1ccc(S(=O)(=O)Oc2cc3c(C)nnc(-c4ccccc4F)n3n2)cc1,,Cc1ccccc1C,,,,val
US20070191333A1,C=O.CC(NC[Si](C)(C)C)c1ccccc1.CO>>COCN(C[Si](C)(C)C)C(C)c1ccccc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US05104867,COS(=O)(=O)F.COc1ccc(CSC2CCN(C)CC2)cc1>>COc1ccc(CSC2CC[N+](C)(C)CC2)cc1.O=S(=O)([O-])F,,ClCCl,,,,val
US20030208018A1,C=C(C)C(=O)OC.C=C(C)C(=O)OCCO.C=CC(=O)OCCS(=O)(=O)c1ccc(C)cc1>>C=C(C)C(=O)OC.C=C(C)C(=O)OCCO.C=CC(=O)OCCS(=O)(=O)c1ccc(C)cc1,,C1CCOC1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20050026973A1,CCOC(C(=O)OC)P(=O)(OCC)OCC.O=Cc1ccc(OCCCl)cc1>>CCOC(=Cc1ccc(OCCCl)cc1)C(=O)OC,,C1CCOC1,,[H-].[Na+],,val
US04547508,COc1ccc(CC(NC(=O)c2ccccc2)c2cccnc2)cc1OC>>COc1cc2c(cc1OC)C(c1ccccc1)=NC(c1cccnc1)C2,,O=P(Cl)(Cl)Cl,,,,val
US04316839,C=O.CCOC(=O)C(N)=C1CN(C)C(=O)c2ccccc2N1>>CCOC(=O)c1ncn2c1CN(C)C(=O)c1ccccc1-2,,ClCCl,,,,val
US20050107395A1,COc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccncc2)NC(=O)OC(C)(C)C)CC1>>COc1ccccc1N1CCN(C(=O)[C@H](N)Cc2ccncc2)CC1,,C1CCOC1,,Cl,,val
US05589477,COC(=N)c1ccc(OC)cc1.Cl.N>>COc1ccc(C(=N)N)cc1.Cl,,CO,,,,val
US04267333,O=C1Nc2ccccc2C1=O.[K+].[OH-]>>Nc1ccccc1C(=O)C(=O)[O-].[K+],,O,,Cl,,val
US20160185764A1,CS(=O)(=O)Cl.Cc1nc(CO)ccc1Br>>Cc1nc(COS(C)(=O)=O)ccc1Br,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,O,val
US04612314,CCCCCCCC(=O)OCC(COC(=O)CCCCCCC)OCn1cnc2c(=O)[nH]c(NC(c3ccccc3)(c3ccccc3)c3ccc(OC)cc3)nc21>>CCCCCCCC(=O)OCC(COC(=O)CCCCCCC)OCn1cnc2c(=O)[nH]c(N)nc21,,CC(=O)O,O,N#N,,val
US03933917,Cc1cc(C)cc(C(C)(C)C)c1.O=C(Cl)c1ccccc1>>Cc1cccc(C)c1C(=O)c1ccccc1,,c1ccccc1,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20070099990A1,Cc1c(CCCO)c2c(c(C)c1NC(=O)OCC(Cl)(Cl)Cl)C(c1ccc(C(C)C)cc1)CO2.NCCO>>Cc1c(CCCO)c2c(c(C)c1NC(=O)NCCO)C(c1ccc(C(C)C)cc1)CO2,,CCCCCC,CCOC(C)=O,,,val
US20130150364A1,CC(C)(C)OC(=O)N1CC[C@H](CO)C1.CSc1nc(-n2c(C(F)F)nc3ccccc32)cc(-n2c(C(F)F)nc3ccccc32)n1>>CSc1nc(OC[C@H]2CCN(C(=O)OC(C)(C)C)C2)cc(-n2c(C(F)F)nc3ccccc32)n1,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110301161A1,CCOC(=O)Cn1nc(C)nc1-c1ccccc1-c1nc2cc(-c3cnc(N)nc3)ccc2n1C(C)(C)C>>Cc1nc(-c2ccccc2-c2nc3cc(-c4cnc(N)nc4)ccc3n2C(C)(C)C)n(CC(=O)O)n1,,CC#N,,,,val
US20070117854A1,C=O.CC(C)c1cc[nH]n1>>CC(C)c1ccn(CO)n1,,CC(C)=O,,CCN(CC)CC,,val
US05714488,C1CCOC1.CCOC(=O)C[Si](C)(C)C.O=C(c1ccc(OCc2ccc3ccccc3n2)cc1)c1ccc(OCc2ccc3ccccc3n2)cc1>>C=C(C(=O)OCC)c1ccc(OCc2ccc3ccccc3n2)cc1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20080039452A1,CC(=O)OC(C)=O.NC[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CCN2C(=O)[C@H]1CCCC[C@H]1NC(=O)c1ccccc1>>CC(=O)NC[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CCN2C(=O)[C@H]1CCCC[C@H]1NC(=O)c1ccccc1,,C1CCOC1,,,,val
US06525074B2,BrB(Br)Br.COc1cccc(S(=O)(=O)NCCCO)c1>>O=S(=O)(NCCCBr)c1cccc(O)c1,,ClCCl,,,,val
US20140142105A1,CNC.C[C@@H](NC(=O)OC(C)(C)C)C(=O)O>>C[C@@H](NC(=O)OC(C)(C)C)C(=O)N(C)C,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150266916A1,CO.O=C(O)[C@@]12CO[C@@](c3ccc(Cl)c(Cc4ccc(OC(F)(F)F)cc4)c3)(O1)[C@H](OCc1ccccc1)[C@@H](OCc1ccccc1)[C@@H]2OCc1ccccc1>>COC(=O)[C@@]12CO[C@@](c3ccc(Cl)c(Cc4ccc(OC(F)(F)F)cc4)c3)(O1)[C@H](OCc1ccccc1)[C@@H](OCc1ccccc1)[C@@H]2OCc1ccccc1,,C1CCOC1,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20110313002A1,CCOC[C@@H](Cn1ccc(N)n1)OCC.COc1cccc2c1CC1=C(O2)C(=O)N([C@@H](CC2CCCCC2)C(=O)O)C1>>COc1cccc2c1CC1=C(O2)C(=O)N([C@@H](CC2CCCCC2)C(=O)Nc2ccn(C[C@@H]3COC(C)(C)O3)n2)C1,,C1CCOC1,O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080139631A1,C/C(N)=C/C(=O)OC(C)(C)C.O=C1C=CC(=O)C(C(F)(F)F)=C1>>Cc1[nH]c2ccc(O)c(C(F)(F)F)c2c1C(=O)OC(C)(C)C,,CCO,,ClCCl,,val
US20140288063A1,COc1ccc(COc2nc(SC)ncc2C(=O)NCc2ccc(F)cc2)cc1Cl.O=C(OO)c1cccc(Cl)c1>>COc1ccc(COc2nc(S(C)=O)ncc2C(=O)NCc2ccc(F)cc2)cc1Cl,,ClCCl,,,,val
US04518597,O=C1Nc2ccc(OCCCCO)cc2CO1.O=S(Cl)Cl>>O=C1Nc2ccc(OCCCCCl)cc2CO1,,c1ccncc1,,,,val
US20150038488A1,CS(=O)(=O)OS(C)(=O)=O.C[C@@H](Oc1nc(-c2ccc(N3CCNCC3)cc2)cc2ncn(C3CC3)c12)[C@H]1CNC(=O)C1.O=C(O)C(F)(F)F>>C[C@@H](Oc1nc(-c2ccc(N3CCN(S(C)(=O)=O)CC3)cc2)cc2ncn(C3CC3)c12)[C@H]1CNC(=O)C1.O=C(O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20120149718A1,CO.CS(=O)(=O)c1ccc(CC(=O)O)cc1>>COC(=O)Cc1ccc(S(C)(=O)=O)cc1,O=S(=O)(O)O,,,,,val
US20100249071A1,COC(=O)c1cc(F)c(OCC2COC(C)(C)N2C(=O)OC(C)(C)C)cc1Cl>>CC(C)(C)OC(=O)N1C(COc2cc(Cl)c(C(=O)O)cc2F)COC1(C)C,,C1CCOC1,O,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US04898872,COc1ccc2cc(Nc3ccccc3[N+](=O)[O-])cc(C)c2n1>>COc1ccc2cc(Nc3ccccc3N)cc(C)c2n1,,CCO,,C,,val
US05635510,ClCCCl.O=C1N=CN(c2ccc(F)cc2)C12CCN(Cc1ccccc1)CC2>>Cl.O=C1N=CN(c2ccc(F)cc2)C12CCNCC2,,CO,,CC(Cl)OC(=O)Cl,,val
US20080085890A1,CN1CCN(c2ccc(N)cc2)CC1.COC=C1C(=O)NC(=O)c2ccc(C(=O)O)cc21>>CN1CCN(c2ccc(N/C=C3\C(=O)NC(=O)c4ccc(C(=O)O)cc43)cc2)CC1,,CN(C)C=O,,,,val
US20040067966A1,COC(=O)C12CCC(CO)(CC1)CC2>>O=C(O)C12CCC(CO)(CC1)CC2,,C1CCOC1,CO,[Li+].[OH-],,val
US20120227756A1,COc1ccc(C=O)cc1.NS(=O)(=O)c1ccccc1>>COc1ccc(C=NS(=O)(=O)c2ccccc2)cc1,,O,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US20160158207A1,CC(=O)N1CCc2[nH]nc(Nc3cccc(-c4cnn(C)c4)c3)c2C1.FC(F)(F)CI>>CC(=O)N1CCc2c(c(Nc3cccc(-c4cnn(C)c4)c3)nn2CC(F)(F)F)C1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060217387A1,NC(CO)CO.O=S(=O)(Cl)c1ccc(Br)s1>>O=S(=O)(NC(CO)CO)c1ccc(Br)s1,,C1CCOC1,,CCN(CC)CC,,val
US20130116233A1,O=C(O)/C=C/c1cc(Br)co1.O=S(Cl)Cl>>O=C(Cl)/C=C/c1cc(Br)co1,,CN(C)C=O,ClC(Cl)Cl,,,val
US20040127574A1,CC(C)c1ccc(CCl)cc1.CCOC(=O)CC(=O)c1ccc(F)cc1>>CCOC(=O)C(Cc1ccc(C(C)C)cc1)C(=O)c1ccc(F)cc1,,COCCOC,,O,[H-].[Na+],val
US20150232445A1,BrCc1ccccc1.Brc1cnn(C2CCNCC2)c1>>Brc1cnn(C2CCN(Cc3ccccc3)CC2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140249104A1,O=C(NC1=N[C@](CF)(c2cccc(Br)c2)C[C@@H](C(F)(F)F)O1)c1ccccc1>>NC1=N[C@](CF)(c2cccc(Br)c2)C[C@@H](C(F)(F)F)O1,,CO,,C1CCC2=NCCCN2CC1,,val
US20130126831A1,COC(=O)c1ccc(Cl)cc1N.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Br)c(Cl)cc1N,,CN(C)C=O,,,,val
US20160221972A1,COC(=O)c1ccc(CNC2(CO)CC2)c(Br)c1>>COC(=O)c1ccc2c(c1)OCC1(CC1)NC2,[Cu]I,CC(C)O,,O=C([O-])[O-].[K+].[K+],,val
US20090163488A1,Cc1cccnc1C(=O)Nc1cccc(Oc2ccc3nc(N)cn3c2)c1.O=S(=O)(Cl)C1CC1>>Cc1cccnc1C(=O)Nc1cccc(Oc2ccc3nc(NS(=O)(=O)C4CC4)cn3c2)c1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20120101093A1,CCOC(=O)c1cn2cc(O)ccc2n1.OCCOC1CCCCO1>>CCOC(=O)c1cn2cc(OCCOC3CCCCO3)ccc2n1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070281936A1,Cc1ccc(-c2cc(C#N)nc(N(C)C)n2)o1.O.[Li+].[OH-]>>Cc1ccc(-c2cc(C(=O)[O-])nc(N(C)C)n2)o1.[Li+],,CO,O,C1CCOC1,Cl,val
US20030199553A1,CCOC(=O)CN1CCCOc2ccc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)cc21>>O=C(O)CN1CCCOc2ccc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)cc21,,C1CCOC1,CO,[Na+].[OH-],,val
US04977165,CN(C)C=O.CS(=O)(=O)Nc1ccc(C(=O)CCC(=O)O)cc1.On1nnc2ccccc21>>Cc1cccc(CCN)n1,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US06156801,O=S(Cl)Cl.O=[N+]([O-])c1cc(CO)ccc1Oc1ccc(OCc2ccccc2)cc1>>O=[N+]([O-])c1cc(CCl)ccc1Oc1ccc(OCc2ccccc2)cc1,,ClC(Cl)Cl,,,,val
US08383625B2,CN1CC[C@@H](O)C1=O.O=C(CBr)Nc1cnccn1>>C[N+]1(CC(=O)Nc2cnccn2)CCC(O)C1.[Br-],,CC#N,,,,val
US05344828,C=CC(=O)OCC.c1ccc2c(c1)Cc1ccccc1N1CCNCC21>>CCOC(=O)CCN1CCN2c3ccccc3Cc3ccccc3C2C1,,CCO,,,,val
US20140371201A1,COc1cc(Br)c(C)cc1-n1c(=O)ccc2cc(S(=O)(=O)Oc3c(F)c(F)c(F)c(F)c3F)ccc21.Nc1ncccn1>>COc1cc(Br)c(C)cc1-n1c(=O)ccc2cc(S(=O)(=O)Nc3ncccn3)ccc21,,CCOC(C)=O,Cl,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20120142668A1,CC[C@@H](/C=C/C(=O)OC)NC(=O)[C@@H]1CCN1C(=O)OC(C)(C)C>>CC[C@@H](/C=C/C(=O)O)NC(=O)[C@@H]1CCN1C(=O)OC(C)(C)C,,C1CCOC1,O,[Li+].[OH-],,val
US20140213586A1,COCOCCn1cc(C(=O)C(Cl)c2ccccc2)c2cc(F)ccc21.COc1cccc(N)c1>>COCOCCn1cc(C(=O)C(Nc2cccc(OC)c2)c2ccccc2)c2cc(F)ccc21,,CC#N,,,,val
US20040248897A1,Cc1ccc(NS(=O)(=O)c2ccccc2)cc1N.N#Cc1ccc(CC(=O)O)cc1>>Cc1ccc(NS(=O)(=O)c2ccccc2)cc1NC(=O)Cc1ccc(C#N)cc1,,C1CCOC1,,,,val
US20150291597A1,C#CCNc1nc(NCCC)nc(N(CC#C)OC)n1.Cl>>C#CCNc1nc(NCCC)nc(N(CC#C)OC)n1.Cl,,CCOCC,,,,val
US20100093654A1,Cc1c(Br)cccc1C(=O)O.O=C1CCC(=O)N1I>>Cc1c(Br)cc(I)cc1C(=O)O,,O=S(=O)(O)O,,,,val
US20100256365A1,COc1cccc(C(=O)c2cn(C(=O)OC(C)(C)C)c3ncc(-c4cccs4)cc23)c1F>>O=C(c1cccc(O)c1F)c1c[nH]c2ncc(-c3cccs3)cc12,,ClCCl,,BrB(Br)Br,,val
US20060264429A1,BrCCBr.O=[N+]([O-])c1cc(Cl)cc(O)c1O>>O=[N+]([O-])c1cc(Cl)cc2c1OCCO2,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US07396844B1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.N#Cc1ccc(C(=O)NCCOc2cccc(C#N)c2)cc1>>N#Cc1ccc(C(=S)NCCOc2cccc(C#N)c2)cc1,,Cc1ccccc1,,,,val
US20060063817A1,Cn1c(=O)n(CCCC(C)(C)[N+](=O)[O-])c2c(F)cccc21>>Cn1c(=O)n(CCCC(C)(C)N)c2c(F)cccc21,[Ni],CO,,[H][H],,val
US20160264532A1,COC(=O)c1ccc([N+](=O)[O-])c(C(=O)OC)c1>>COC(=O)c1ccc(N)c(C(=O)OC)c1,[Pd],CCOC(C)=O,,,,val
US20020007071A1,CNC.Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCC(C)C(=O)Cl>>Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCC(C)C(=O)N(C)C,,CO,,,,val
US20130090334A1,Cc1sc(-c2cccnc2)nc1O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1sc(-c2cccnc2)nc1OS(=O)(=O)C(F)(F)F,,C1CCOC1,,[H-].[Na+],,val
US20090042892A1,COC(=O)c1cc2c(cc1N)CN(C(=O)OCc1ccccc1)C2.II>>COC(=O)c1cc2c(cc1I)CN(C(=O)OCc1ccccc1)C2,,ClC(Cl)Cl,,CC(C)(C)ON=O,,val
US20100087489A1,CC(C)COC(=O)c1cccc(-n2ncc3cc(O[C@H](c4ccc5c(c4)OCCO5)[C@H](C)N)ccc32)c1.CC(F)(F)C(=O)O>>CC(C)COC(=O)c1cccc(-n2ncc3cc(O[C@H](c4ccc5c(c4)OCCO5)[C@H](C)NC(=O)C(C)(F)F)ccc32)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060089367A1,COCCC(=O)O.Fc1cc2nc(COc3ccccc3)n(Cc3ccc(OC(F)(F)F)cc3)c2cc1N1CCNCC1>>COCCC(=O)N1CCN(c2cc3c(cc2F)nc(COc2ccccc2)n3Cc2ccc(OC(F)(F)F)cc2)CC1,,ClCCl,,,,val
US20060058320A1,COc1ccc(CNc2nc(-c3ccc(C(=O)O)cc3)cc3nc(-c4ccco4)nn23)cc1OC.ClCCl>>COC(=O)c1ccc(-c2cc3nc(-c4ccco4)nn3c(NCc3ccc(OC)c(OC)c3)n2)cc1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20070299051A1,CC(=O)CCC(C)=O.Cc1cc(N)cc2c1Oc1c(C)cc(C(=O)O)cc1S(=O)(=O)C2>>Cc1cc(-n2c(C)ccc2C)cc2c1Oc1c(C)cc(C(=O)O)cc1S(=O)(=O)C2,,Cc1ccccc1,,CC(=O)O,,val
US20090048281A1,CCOC(=O)C(O)(c1cccs1)C1CCCCC1>>O=C(O)C(O)(c1cccs1)C1CCCCC1,,C1CCOC1,CO,[Na+].[OH-],,val
US20070032485A1,CCC=O.COc1ccc(N)cn1.c1ccc2[nH]nnc2c1>>CCC(Nc1ccc(OC)nc1)n1nnc2ccccc21,,Cc1ccccc1,,,,val
US20150344466A1,CCOC(=O)c1cc(Cc2cccc(OC(F)(F)F)c2)on1>>O=C(O)c1cc(Cc2cccc(OC(F)(F)F)c2)on1,,O,,CCO,[Na+].[OH-],val
US20100190814A1,CC(C)(C)COC(=O)Cl.CCC(CC)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)Nc1cc(Cl)ccc12)C(=O)NS(C)(=O)=O>>CCC(CC)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)N(C(=O)OCC(C)(C)C)c1cc(Cl)ccc12)C(=O)NS(C)(=O)=O,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,,,val
US20050049245A1,CNCC(O)c1ccoc1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)sc21>>CN(Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2s1)CC(O)c1ccoc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20150291597A1,C#CCNc1nc(NCCC)nc(NOC(C)(C)C)n1.Cl>>C#CCNc1nc(NCCC)nc(NOC(C)(C)C)n1.Cl,,CCOCC,,,,val
US20120178770A1,COc1cccc(Nc2c3c(n(C)c2-c2ccnc(N)n2)CCN(C(=O)OC(C)(C)C)C3=O)c1>>Cn1c2c(c(Nc3cccc(O)c3)c1-c1ccnc(N)n1)C(=O)NCC2,,ClCCl,,BrB(Br)Br,O,val
US20090082358A1,CCOC(=O)N1C=Cc2cccnc2C1c1ccc(F)cc1>>CCOC(=O)N1CCc2cccnc2C1c1ccc(F)cc1,[Pd],CCO,,,,val
US06384041B1,CCc1cc2c(OCC(=O)OC)nc(SC)nc2n1Cc1cccc(F)c1>>CCc1cc2c(OCC(=O)OC)ncnc2n1Cc1cccc(F)c1,[Ni],CCO,,,,val
US20100168082A1,Cn1ccnc1.O=Cc1cc(Oc2ccc3c(ccn3C(=O)Nc3cccc(C(F)(F)F)c3)c2)ncn1>>Cn1ccnc1C(O)c1cc(Oc2ccc3c(ccn3C(=O)Nc3cccc(C(F)(F)F)c3)c2)ncn1,,C1CCOC1,,[Li]CCCC,,val
US20140343032A1,N#Cc1nccs1.[Cl-].[NH4+]>>Cl.N=C(N)c1nccs1,,CO,,C[O-].[Na+],,val
US20040138277A1,CC(C)(C)c1cccc(O)c1.CCOC(=O)C(C)Br>>CCOC(=O)C(C)Oc1cccc(C(C)(C)C)c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US04806650,O=C(NC(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(Cl)Cl>>O=C(NC[C@H](O)[C@@H](O)[C@H](O)C(=O)CO)C(Cl)Cl,,O,,O=P(O)(O)O,,val
US20040157844A1,C1CCNCC1.COc1ccc(Oc2c(Cl)cc(-n3ncc(=O)[nH]c3=O)cc2Cl)cc1S(=O)(=O)Cl>>COc1ccc(Oc2c(Cl)cc(-n3ncc(=O)[nH]c3=O)cc2Cl)cc1S(=O)(=O)N1CCCCC1,,CCOCC,CN(C)C=O,,,val
US20100056527A1,CC(C)N.Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12>>Cc1cc(C(=O)NC(C)C)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20070099930A1,CCO.CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ccccc1.O=C1N=C(O)c2ccccc21>>COc1ccc(CN2C(=O)c3ccccc3C2CC(=O)O)cc1,,CCO,O,O=C([O-])[O-].[K+].[K+],,val
US20140128606A1,CI.Cc1ccc2oc(S)nc2n1>>CSc1nc2nc(C)ccc2o1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070082912A1,CCOC(=O)c1ccnc(N)c1.COc1ccc(COc2ccc(Cl)cc2C(=O)CCC(C)=O)cc1>>CCOC(=O)c1ccnc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(OC)cc2)c1,,Cc1ccccc1,,,,val
US20080076924A1,COC(=O)c1cnc(N2CCN(C(=S)Nc3cccc4ncccc34)C(C(C)C)C2)cn1>>CC(C)C1CN(c2cnc(C(=O)O)cn2)CCN1C(=S)Nc1cccc2ncccc12,,C1COCCO1,O,[Li+].[OH-],,val
US05656573,O=C(Cl)c1ccc(C(F)(F)F)cc1[N+](=O)[O-]>>O=Cc1ccc(C(F)(F)F)cc1[N+](=O)[O-],,CC(C)=O,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040019210A1,COc1cc(OC)c(F)c(N=Cc2cnc(SC)nc2NC2CC2)c1F>>COc1cc(OC)c(F)c(NCc2cnc(SC)nc2NC2CC2)c1F,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040121964A1,CC1(NC(=O)OCc2ccccc2)CCC(O[Si](C)(C)C(C)(C)C)CC1>>CC1(NC(=O)OCc2ccccc2)CCC(O)CC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040209878A1,Brc1ccccn1.N#Cc1ccc(B(O)O)cc1>>N#Cc1ccc(-c2ccccn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20150183781A1,Cn1cc(-c2cnc3[nH]cc(-c4cnn(Cc5cccc([N+](=O)[O-])c5)c4)c3c2)cn1>>Cn1cc(-c2cnc3[nH]cc(-c4cnn(Cc5cccc(N)c5)c4)c3c2)cn1,[Pd],C1CCOC1,CO,[H][H],,val
US04477447,CC(C)OC(=O)OC(C)I.CON=C(C(=O)NC1C(=O)N2C(C(=O)[O-])=CCS[C@H]12)c1csc(N)n1>>CON=C(C(=O)NC1C(=O)N2C(C(=O)OC(C)OC(=O)OC(C)C)=CCS[C@H]12)c1csc(N)n1,,CS(C)=O,,CCOC(C)=O,O,val
US20040167131A1,CC(C)(C)OC(=O)NC1(C(=O)Nc2ccc(-c3ccccc3S(C)(=O)=O)cc2F)CC1.O=C=Nc1ccc(Cl)cc1>>CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C2(NC(=O)Nc3ccc(Cl)cc3)CC2)c(F)c1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US04483987,CC(=O)OC(C)=O.Nc1nc(-c2ccccc2)c(CCO)c2ncnn12>>CC(=O)OCCc1c(-c2ccccc2)nc(N)n2ncnc12,,c1ccncc1,,,,val
US20110015157A1,COC(=O)Cl.C[C@@H](c1ccc(C2CCNCC2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O>>COC(=O)N1CCC(c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20030220324A1,CN(C)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)OC(C)(C)C)CC1>>CN(C)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1,,C1COCCO1,,Cl,,val
US20160272628A1,CC(=O)N(C)CC1c2cc(-c3c[nH]c4cc(F)ccc34)ccc2S(=O)(=O)N1C(C)(C)C>>CC(=O)N(C)CC1NS(=O)(=O)c2ccc(-c3c[nH]c4cc(F)ccc34)cc21,,O=C(O)C(F)(F)F,,,,val
US20100168418A1,CCOC(=O)C1(CCCn2c(=O)ccc3ccc(OC)cc32)CCN(CCCc2ccccc2)CC1>>COc1ccc2ccc(=O)n(CCCC3(C(=O)O)CCN(CCCc4ccccc4)CC3)c2c1,,CCO,,[Na+].[OH-],,val
US04055595,CCOC(=O)C(O)(C(F)(F)F)C(F)(F)F.ClCc1ccc(Cl)cc1>>CCOC(=O)C(OCc1ccc(Cl)cc1)(C(F)(F)F)C(F)(F)F,,CN(C)C=O,,[H-].[Na+],,val
US20090203903A1,COc1ccc(F)cc1B(O)O.Cc1nc(C#Cc2ccc(Cl)nc2)cs1>>COc1ccc(F)cc1-c1ccc(C#Cc2csc(C)n2)cn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,O=C([O-])[O-].[K+].[K+],,val
US20110230463A1,OCC1=Cc2sc(COc3ccc(-c4ccccc4)c(C(F)(F)F)c3)cc2CC1>>O=CC1=Cc2sc(COc3ccc(-c4ccccc4)c(C(F)(F)F)c3)cc2CC1,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20080119476A1,COc1cc(F)c(C(C)=O)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C.C[Mg]I>>C=C(C)c1cc(-c2ccc(C(F)(F)F)cc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)c(OC)cc1F,,CCOCC,CCOCC,,,val
US20040092582A1,COc1cc2c(c3c1OC(C)(C)C3)C(c1cccc(N(CCCS(=O)(=O)N=CN(C)C)S(C)(=O)=O)c1)=NC(C)(C)C2.Cl>>COc1cc2c(c3c1OC(C)(C)C3)C(c1cccc(N(CCCS(N)(=O)=O)S(C)(=O)=O)c1)=NC(C)(C)C2.Cl,,O,,O=C([O-])O.[Na+],,val
US04866091,NC(=O)c1ccc([N+](=O)[O-])c(Oc2ccc(F)cc2F)c1>>NC(=O)c1ccc(N)c(Oc2ccc(F)cc2F)c1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20140080788A1,CCOC(=O)Cn1cc(-c2cccc3c2CCCN3C(=O)CCCO)cn1.Oc1cc(Cl)c(Cl)cc1Cl>>CCOC(=O)Cn1cc(-c2cccc3c2CCCN3C(=O)CCCOc2cc(Cl)c(Cl)cc2Cl)cn1,,ClCCl,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US08598161B2,C=C(CCCO[Si](C)(C)C(C)(C)C)C(=O)c1cc(-c2cncnc2)c(F)cc1F.NC(N)=S>>NC1=N[C@]2(c3cc(-c4cncnc4)c(F)cc3F)OCCC[C@@H]2CS1,,C1CCOC1,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080044379A1,CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2cnc(-c3ccc(-c4cnc([C@@H]5CCCN5C(=O)OCc5ccccc5)[nH]4)cc3)nc2)[nH]1>>CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2cnc(-c3ccc(-c4cnc([C@@H]5CCCN5)[nH]4)cc3)nc2)[nH]1,[Pd],CO,,O,O=C([O-])[O-].[K+].[K+],val
US20130190522A1,CC[C@@H](c1cccc(OS(=O)(=O)c2ccc(C)cc2)c1)[C@@H](C)CN(C)C>>CC[C@@H](c1cccc(OS(=O)(=O)c2ccc(C)cc2)c1)[C@@H](C)CN(C)C,,Cl,ClCCl,O=C(O)C(=O)O,,val
US20140350019A1,Cc1ccc(OCC(=O)OC(C)C)c(C)c1NCc1cc(O)cc(-c2cccc(F)c2)c1>>Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(O)cc(-c2cccc(F)c2)c1,,C1CCOC1,,[Na+].[OH-],,val
US20090156604A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.NN=C(N)c1ccccn1>>CC(C)(C)OC(=O)N1CCC(C(=O)N/N=C(\N)c2ccccn2)CC1,,ClCCl,O,O=C(c1ncc[nH]1)c1ncc[nH]1,,val
US20140179733A1,CC(C)c1c(N)cnn1-c1ccc(F)cc1.Cc1c(Cl)c(C(F)(F)F)nn1C(C)C(=O)O>>Cc1c(Cl)c(C(F)(F)F)nn1C(C)C(=O)Nc1cnn(-c2ccc(F)cc2)c1C(C)C,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070135456A1,CCCn1c(=O)[nH]c(=O)c2[nH]cnc21.O=C1CCC(=O)N1Cl>>CCCn1c(=O)[nH]c(=O)c2[nH]c(Cl)nc21,,CN(C)C=O,,,,val
US05608056,C=CCOC(=O)N1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CCN.O=[N+]([O-])c1ccc(-[n+]2ccccc2)c([N+](=O)[O-])c1.[Cl-]>>C=CCOC(=O)N1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CC[n+]1ccccc1.[Cl-],,CCCCO,,,,val
US20110105567A1,COC(=O)c1ccn(Cc2ccccc2)c1C(C)C>>CC(C)c1c(C(=O)O)ccn1Cc1ccccc1,,CO,,Cl,[Na+].[OH-],val
US20070225267A1,CC(C)[S-].C[C@@H]1N[C@@H]([C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)CO[C@H]1OCC(C)(CF)CF>>CC(C)Sc1cc(F)cc(C[C@H](N)[C@H](O)[C@H]2CO[C@@H](OCC(C)(CF)CF)[C@H](C)N2)c1,,CN1CCCC1=O,CO,[Cl-].[NH4+],,val
US20050250810A1,CN(C)C=O.Cc1cc2ccccc2n1C>>Cc1c(C=O)c2ccccc2n1C,,O,,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US20080318927A1,CCOC(=O)CN1C(=O)CO[C@H]2Cc3ccccc3[C@H]21>>O=C(O)CN1C(=O)CO[C@H]2Cc3ccccc3[C@H]21,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20060116357A1,CC(C)CNCCO.COc1cc2c(Nc3cc(CC(=O)Nc4cc(F)cc(F)c4)[nH]n3)ncnc2cc1OCCCCl>>COc1cc2c(Nc3cc(CC(=O)Nc4cc(F)cc(F)c4)[nH]n3)ncnc2cc1OCCCN(CCO)CC(C)C,,CN1CCCC1=O,,[I-].[K+],,val
US20070155726A1,COC(=O)c1ccc(CN2CCCN(CCOc3ccc(Cc4ccccc4)cc3)CC2)cc1>>O=C(O)c1ccc(CN2CCCN(CCOc3ccc(Cc4ccccc4)cc3)CC2)cc1,,CO,,[Na+].[OH-],,val
US05142029,CCCCCCCCCCCCN.O=C(Oc1ccccc1)c1cc(O)c2ccccc2c1O>>CCCCCCCCCCCCNC(=O)c1cc(O)c2ccccc2c1O,,CC#N,,,,val
US20120283297A1,N#Cc1cc2cn[nH]c2cc1F.NO>>N=C(NO)c1cc2cn[nH]c2cc1F,,CCO,,Cl,O=C([O-])O.[Na+],val
US20060100203A1,CCOC(=O)c1ncnnc1NC(=O)Cc1c(F)cc(F)cc1F>>O=C1Nc2nncnc2C(=O)C1c1c(F)cc(F)cc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04863942,CCCc1c(OCCCOc2cccc(NC(=O)C(=O)OC)c2C)ccc(C(C)=O)c1O>>CCCc1c(OCCCOc2cccc(NC(=O)C(=O)O)c2C)ccc(C(C)=O)c1O,,Cc1ccccc1,,,,val
US20070197577A1,CCOC(=O)CC(CC(C)C)C(=O)NCc1ccc(-c2ccc(Cl)c(Cl)c2)cc1.NO>>CC(C)CC(CC(=O)NO)C(=O)NCc1ccc(-c2ccc(Cl)c(Cl)c2)cc1,,CO,,Cl,[K+].[OH-],val
US04508716,ClCCN1c2ccc(Cl)cc2C(c2ccco2)=NCC1CCl.O=C(OO)c1cccc(Cl)c1>>[O-][N+]1=C(c2ccco2)c2cc(Cl)ccc2N(CCCl)C(CCl)C1,,ClCCl,,[Na+].[OH-],,val
US20070281952A1,Nc1ccc(S(=O)(=O)O)cc1.c1ccccc1>>Nc1ccc(S(=O)(=O)c2ccccc2)cc1,,O=C(O)C(F)(F)F,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20090124654A1,C=C(C)c1ccc(C[C@H](NC(=O)c2cc3ccc(Oc4ccc(C(C)(C)C)cc4)cc3c(CC3CCCC3)n2)C(=O)OC)s1>>COC(=O)[C@H](Cc1ccc(C(C)C)s1)NC(=O)c1cc2ccc(Oc3ccc(C(C)(C)C)cc3)cc2c(CC2CCCC2)n1,[Pd],,,,,val
US06699861B1,Cc1cc(C(=O)O)c(N)cc1Cl.N#CCCl>>Cc1cc2c(=O)[nH]c(CCl)nc2cc1Cl,,CO,,[Na],,val
US20160152623A1,C[C@@H](N[S@@](=O)C(C)(C)C)c1cc(Cl)ccc1Br>>C[C@@H](N)c1cc(Cl)ccc1Br,,CO,,Cl,,val
US20120088798A1,Cc1cc(C[C@H]2CN(C(=O)OC(C)(C)C)C[C@H]2OCCNCc2ccccc2F)nc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1>>Cc1cc(N)nc(C[C@H]2CNC[C@H]2OCCNCc2ccccc2F)c1,,CO,,Cl,,val
US20160229837A1,Cc1cnc(Cl)nc1N(C)C1CCN(c2ccc(C#N)cn2)CC1.Cn1cc(N)cn1>>Cc1cnc(Nc2cnn(C)c2)nc1N(C)C1CCN(c2ccc(C#N)cn2)CC1,,CCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20040157839A1,Cc1nc2c(-c3ccc(Cl)cc3)c(-c3ccccc3Cl)nn2c(=O)[nH]1.O=P(Cl)(Cl)Cl>>Cc1nc(Cl)n2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)c2n1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US05366972,CCN1c2ncccc2C(OS(C)(=O)=O)Nc2c(C)cc(C)nc21.CON>>CCN1c2ncccc2C(=NOC)Nc2c(C)cc(C)nc21,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US06177452B1,CI.O=C(O)CCc1oc(=S)[nH]c1-c1ccc(Cl)cc1>>CSc1nc(-c2ccc(Cl)cc2)c(CCC(=O)O)o1,,CN(C)C=O,O,Cl,[Na+].[OH-],val
US20080132507A1,C=CCOc1ccc(C(Nc2ccc(C(=N)N)cc2)C(=O)OC)cc1OCC=C.Cl>>C=CCOc1ccc(C(Nc2ccc(C(=N)N)cc2)C(=O)O)cc1OCC=C.Cl,,C1CCOC1,CO,CCOCC,[Na+].[OH-],val
US20160145245A1,CC(C)(C)OC(=O)N1CC[C@H](O)C1.CS(=O)(=O)OCCOCCOCCOC(F)(F)F>>FC(F)(F)OCCOCCOCCO[C@H]1CCNC1,,C1CCOC1,,[H-].[Na+],,val
US20130261086A1,CCOP(=O)(Cc1ccc([N+](=O)[O-])c(OC)c1)OCC>>CCOP(=O)(Cc1ccc(N)c(OC)c1)OCC,[Pd],CCO,,,,val
US20060035922A1,BrCc1ccccc1.Cc1cc(O)cc(Br)c1>>Cc1cc(Br)cc(OCc2ccccc2)c1,,CC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090286791A1,O=C(NCCNC(=O)c1cn(-c2ccccc2)nc1C(F)(F)F)c1cnc(Cl)c(Br)c1.OCC(F)(F)F>>O=C(NCCNC(=O)c1cn(-c2ccccc2)nc1C(F)(F)F)c1cnc(OCC(F)(F)F)c(Br)c1,,C1CCOC1,,[H-].[Na+],,val
US20090118287A1,OCC1CCC(COCc2ccccc2)CC1>>O=CC1CCC(COCc2ccccc2)CC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20100056524A1,CN1CCN(CCCNC(=O)OC(C)(C)C)C1=O>>CN1CCN(CCCN)C1=O,,C1COCCO1,,Cl,,val
US20160263087A1,O=S(=O)(c1ccccc1)n1cc(-c2cn[nH]c2)c2ccc(F)cc21>>Fc1ccc2c(-c3cn[nH]c3)c[nH]c2c1,,CO,O,[Na+].[OH-],,val
US20050245500A1,COC(=O)c1cc([N+](=O)[O-])ccc1Cl.OCCN1CCCC1>>COC(=O)c1cc([N+](=O)[O-])ccc1OCCN1CCCC1,,Cc1ccccc1,ClCCl,[Na],,val
US20070004710A1,N#CCc1ccc(Br)cn1>>NCCc1ccc(Br)cn1,,C1CCOC1,,B,,val
US20100069391A1,CNc1nc(NC2CCC(C(=O)O)CC2)nc(N2CCN(C)CC2)n1.NCc1ccc(Cl)cc1Cl>>CNc1nc(N[C@H]2CC[C@@H](C(=O)NCc3ccc(Cl)cc3Cl)CC2)nc(N2CCN(C)CC2)n1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US07105509B2,COC(=O)CBr.C[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)NC1N=C(c2ccccc2)c2ccccc2NC1=O>>COC(=O)CN1C(=O)C(NC(=O)C(C)Cc2ccc(Cl)c(Cl)c2)N=C(c2ccccc2)c2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120021017A1,CCOC(=O)c1ccc(NC2(C#N)CCCCC2)cc1.O=S(=O)(O)O>>CCOC(=O)c1ccc(NC2(C(N)=O)CCCCC2)cc1,,O=S(=O)(O)O,,[Na+].[OH-],,val
US20090118284A1,CI.OCc1cc(I)ccn1>>COCc1cc(I)ccn1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US04952722,Cc1ccc(C)c(C(=O)C(C)Cl)c1>>Cc1ccc(C)c2c1CCC2=O,,O=S(=O)(O)O,,,,val
US06518268B1,BrCc1ccccc1.O=Cc1cc([N+](=O)[O-])ccc1O>>O=Cc1cc([N+](=O)[O-])ccc1OCc1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US20110190280A1,CC(C)(C)[Si](C)(C)OCCOc1ccc([N+](=O)[O-])cc1F>>CC(C)(C)[Si](C)(C)OCCOc1ccc(N)cc1F,[Pd],CCOC(C)=O,,,,val
US20080064757A1,CSc1ccccc1C(=O)c1cc(C)ccc1C>>CSc1ccccc1Cc1cc(C)ccc1C,,O,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20140228343A1,C1COCCN1.O=C(O)c1cccc(Br)c1>>O=C(c1cccc(Br)c1)N1CCOCC1,,ClCCl,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US06002008,COc1cc2ncc(C#N)c(Cl)c2cc1OC.Nc1ccc(O)cc1O>>COc1cc2ncc(C#N)c(Nc3ccc(O)cc3O)c2cc1OC,,CCOCCO,,Cl,c1ccncc1,val
US05917090,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OCCCCCc1ccccc1>>O=S(=O)(OCCCCCc1ccccc1)C(F)(F)F,,ClCCl,,O,c1ccncc1,val
US20090054240A1,CNC(=O)[C@H](CNC(=O)OC(C)(C)C)NC(=O)c1cn(C)nc1C(F)(F)F>>CNC(=O)[C@H](CN)NC(=O)c1cn(C)nc1C(F)(F)F,,C1COCCO1,,Cl,,val
US20110117073A1,CN(C(=O)OC(C)(C)C)c1ccc([N+](=O)[O-])cc1>>CN(C(=O)OC(C)(C)C)c1ccc(N)cc1,[Pd],CCOC(C)=O,,[H][H],,val
US20150225412A1,C[C@H](N(Cc1ccc2c(c1)[nH]c(=N)n2CC1CCCN1C(=O)OC(C)(C)C)C(=O)OCc1ccccc1)C(C)(C)C.O=C(O)c1ccc(C(F)F)cc1>>C[C@H](N(Cc1ccc2c(c1)nc(NC(=O)c1ccc(C(F)F)cc1)n2CC1CCCN1C(=O)OC(C)(C)C)C(=O)OCc1ccccc1)C(C)(C)C,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04063925,CC(C)N.Cc1nn(C)c(O)c1C(=O)c1ccc(Cl)cc1Cl>>CC(C)N.Cc1nn(C)c(O)c1C(=O)c1ccc(Cl)cc1Cl,,c1ccccc1,,,,val
US20110218197A1,Cn1nc(C(C)(C)C)c(Cl)c1-c1nc2cc(-c3ccccc3C(F)(F)F)nc(OCCO)c2[nH]1>>Cn1nc(C(C)(C)C)c(Cl)c1-c1nc2cc(-c3ccccc3C(F)(F)F)nc(OCC=O)c2[nH]1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20060079523A1,O=Cc1ccc(Br)nc1.Sc1ccccn1>>O=Cc1ccc(Sc2ccccn2)nc1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20160024060A1,COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(=O)OC)cccc4n3)c(C)c12>>COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(=O)O)cccc4n3)c(C)c12,,c1ccncc1,,[Cl-].[Li+],,val
US20140288264A1,C(=C/c1ccccc1)\c1ccccc1>>C(=Cc1ccccc1)c1ccccc1,,CO,,,,val
US20140179667A1,CC(C)Oc1cc(NC(=O)OC(C)(C)C)c2c(c1)C(=O)NCC2.O=C1CCC(=O)N1Cl>>CC(C)Oc1cc(NC(=O)OC(C)(C)C)c2c(c1Cl)C(=O)NCC2,,CC#N,,,,val
US20090216014A1,FC(F)(F)c1ccc2c(SCc3ccc(CBr)cc3)ccnc2c1.O=c1cc(CN2CCOCC2)occ1O>>O=c1cc(CN2CCOCC2)occ1OCc1ccc(CSc2ccnc3cc(C(F)(F)F)ccc23)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20120295884A1,COC(=O)COc1ccc2c(C(N)=O)cn(CC(=O)N3C[C@H](F)C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1>>NC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(OCC(=O)O)ccc12,,C1CCOC1,O,[Na+].[OH-],,val
US20150191452A1,O=C(NCc1ccc(C(F)(F)F)cc1)C(Br)CCBr>>O=C1C(Br)CCN1Cc1ccc(C(F)(F)F)cc1,,C1CCOC1,O,[H-].[Na+],,val
US20130131039A1,C[Si](C)(C)CCOCn1cc(-c2nc(Cl)cc3nccn23)cn1.Cc1c[nH]cn1>>Cc1cn(-c2cc3nccn3c(-c3cnn(COCC[Si](C)(C)C)c3)n2)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20080269244A1,Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(NC3CCN(C(=O)OC(C)(C)C)CC3)nc2)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(NC3CCNCC3)nc2)cc1,,CCOCC,,Cl,,val
US20060111347A1,O=C(N[C@@H]1CCCc2c1ccc(CN1CCCCC1)c2[N+](=O)[O-])C(F)(F)F>>N[C@@H]1CCCc2c1ccc(CN1CCCCC1)c2[N+](=O)[O-],,CO,O,[Na+].[OH-],,val
US20040097548A1,CC(C)(C)OC(=O)N[C@H]1CCCN[C@H]1c1ccccc1.COC(=O)CBr>>COC(=O)CN1CCC[C@H](NC(=O)OC(C)(C)C)[C@@H]1c1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100234378A1,C#CC(C)(C)N(CCOC)S(=O)(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1.C[Si](C)(C)N=[N+]=[N-]>>COCCN(C(C)(C)c1cnn[nH]1)S(=O)(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1,[Cu]I,CN(C)C=O,CO,,,val
US20090192307A1,Clc1cncc(Cl)c1Cl.Nc1ccc(O)cc1>>Nc1ccc(Oc2c(Cl)cncc2Cl)cc1,,CCOC(C)=O,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US04138564,O=C(O)C1CN(C(=O)OCc2ccccc2)CCN1c1nc(F)ccc1[N+](=O)[O-]>>O=C1Nc2ccc(F)nc2N2CCN(C(=O)OCc3ccccc3)CC12,[Fe],CC(=O)O,,,,val
US20140336177A1,CC(C)(C)OC(=O)Cc1ccnc(N=C(c2ccccc2)c2ccccc2)c1>>CC(C)(C)OC(=O)Cc1ccnc(N)c1,,C1CCOC1,O,Cl,,val
US20070149755A1,CC(=O)N(C)C.O=S(=O)([O-])C(F)(F)F>>CC(=O)N(C)C.O=S(=O)(O)C(F)(F)F,,Cc1ccccc1,,,,val
US20100197655A1,CC(=O)c1cc(Cl)ccc1O.COC(OC)N(C)C>>CN(C)/C=C/C(=O)c1cc(Cl)ccc1O,,CC(C)O,,,,val
US20130065905A1,CC(C)(C)[Si](C)(C)OC(c1cnc(Br)s1)C(F)(F)F.CON(C)C(C)=O>>CC(=O)c1ncc(C(O[Si](C)(C)C(C)(C)C)C(F)(F)F)s1,,C1CCOC1,O,[Li]CCCC,[Cl-].[NH4+],val
US20050272036A1,BrBr.CC(C)C(=O)c1ccc(C(F)(F)F)cc1F>>CC(C)(Br)C(=O)c1ccc(C(F)(F)F)cc1F,,Br,,,,val
US20030069257A1,CCNc1cc(C(C)=O)ccc1[N+](=O)[O-]>>CCNc1cc(C(C)=O)ccc1N,[Pd],CCO,,,,val
US20130116260A1,COC(=O)c1c(C)nc(N[C@@H]2CCCC[C@@H]2NC(=O)OC(C)(C)C)nc1-c1cnn(C)c1.O=[Se]=O>>COC(=O)c1c(C=O)nc(N[C@@H]2CCCC[C@@H]2NC(=O)OC(C)(C)C)nc1-c1cnn(C)c1,,C1COCCO1,,,,val
US20080182861A1,CCOC(=O)C[C@@H]1CC[C@@H](c2ccc(C(C)=O)cc2)CC1.COC(OC)N(C)C>>CCOC(=O)C[C@@H]1CC[C@@H](c2ccc(C(=O)/C=C/N(C)C)cc2)CC1,,CN(C)C=O,,O,,val
US20150166564A1,C[N+](=O)[O-].O=Cc1ccc(F)cc1>>O=[N+]([O-])/C=C/c1ccc(F)cc1,,CC(=O)O,,C,O=C[O-].[NH4+],val
US20050209338A1,CC(=O)O.NC1CCCC1.O=C1CNC(=O)N1c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1>>CC(=O)O.O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1,,CCO,,,,val
US20130172384A1,O=C(Cl)C1CC1.O=c1[nH]nc(-c2ccc(Br)cc2)n1C[C@@H]1CCNC1>>O=C(C1CC1)N1CC[C@@H](Cn2c(-c3ccc(Br)cc3)n[nH]c2=O)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100323994A1,CC(C)N=C=O.COc1ccc(CN(c2cc(N[C@@H]3CC[C@@H](N)CC3)nn3c(C(=O)Nc4ccncc4F)cnc23)C2CC2)cc1>>CC(C)NC(=O)N[C@@H]1CC[C@@H](Nc2cc(NC3CC3)c3ncc(C(=O)Nc4ccncc4F)n3n2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160122336A1,C[Si](C)(C)C(F)(F)F.O=C(c1ccc(Br)c(C(F)F)c1F)C(F)(F)F>>OC(c1ccc(Br)c(C(F)F)c1F)(C(F)(F)F)C(F)(F)F,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US06407248B1,CO[NH3+].CSC(=C[N+](=O)[O-])NCc1cccnc1>>CON=C(C[N+](=O)[O-])NCc1cccnc1,,CC(C)CO,,CCN(CC)CC,,val
US20140256729A1,CCOC(=O)[C@@H]1C[C@H]1c1cncs1>>O=C(O)[C@@H]1C[C@H]1c1cncs1,,CO,,[Na+].[OH-],,val
US20140179666A1,CC(=N)NO.CC(C)(C)OC(=O)N1CC(C)(C)c2cc(C(=O)O)c(Cl)cc21>>Cc1noc(-c2cc3c(cc2Cl)N(C(=O)OC(C)(C)C)CC3(C)C)n1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150329538A1,CNC(C)(C)C.Oc1nc(Cl)nc2c(Br)cccc12>>CN(c1nc2c(Br)cccc2c(=O)[nH]1)C(C)(C)C,,CN1CCCC1=O,,,,val
US20130116248A1,COc1ccc(Nc2c([N+](=O)[O-])cnc3ccc(Br)cc23)cn1>>COc1ccc(Nc2c(N)cnc3ccc(Br)cc23)cn1,[Ni],C1CCOC1,CO,[H][H],,val
US20040259917A1,Fc1cc(F)cc(Br)c1.Oc1cccnc1>>Fc1cc(Br)cc(Oc2cccnc2)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04198419,N#CN1CCC(C#N)(c2ccccc2Sc2ccc(F)cc2)CC1>>N#CC1(c2ccccc2Sc2ccc(F)cc2)CCNCC1,,CC(=O)O,O,Cl,,val
US06936306B1,C1CC[AlH]OC1.CC(=O)O>>C1CC[AlH]OC1.CC(=O)[O-],,O,,,,val
US20130331372A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)[C@@H]1C[C@H]1c1ccc(CC)c(I)c1>>CCOC(=O)[C@@H]1C[C@H]1c1ccc(CC)c(B2OC(C)(C)C(C)(C)O2)c1,,CS(C)=O,,C1COCCO1,CC(=O)[O-].[K+],val
US20040097566A1,COCCl.O=C(c1ccccc1)c1cc(Br)cc(C23CC4CC(CC(C4)C2)C3)c1O>>COCOc1c(C(=O)c2ccccc2)cc(Br)cc1C12CC3CC(CC(C3)C1)C2,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20130281433A1,BrCc1ccccc1.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccc4[nH]nc(C)c4c3)sc2c1-c1ccc(Cl)cc1>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccc4c(c3)c(C)nn4Cc3ccccc3)sc2c1-c1ccc(Cl)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20070179151A1,CC(C)O.Cc1cc(Nc2cc3cc(O)ccc3c(Br)n2)n[nH]1>>Cc1cc(Nc2cc3cc(O)ccc3c(OC(C)C)n2)n[nH]1,,CC(=O)O,,[H-].[Na+],,val
US05208247,CC(=O)OC(C)=O.CCCCCCCCCCCCCCOc1ccc(C(=O)NCc2ccccn2)cc1>>CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2ccccn2)C(C)=O)cc1,CN(C)c1ccncc1,O,,c1ccncc1,,val
US20010053853A1,CCOC(=O)CC(C=CCCCCc1ccc2c(n1)N(C(C)=O)CC2)c1cnc(C)nc1>>CCOC(=O)CC(CCCCCCc1ccc2c(n1)N(C(C)=O)CC2)c1cnc(C)nc1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20040132727A1,COc1cc2nccc(Oc3ccc(NC(=O)CCOc4ccccc4)c(C)c3C)c2cc1OC>>COc1cc2nccc(Oc3ccc(NCCCOc4ccccc4)c(C)c3C)c2cc1OC,,C1CCOC1,,Cl,[Na+].[OH-],val
US06080772,CI.O=[N+]([O-])c1cnc(Sc2nnn[nH]2)s1>>Cn1nnc(Sc2ncc([N+](=O)[O-])s2)n1,,CN(C)C=O,O,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20100240658A1,COC(=O)c1ccc(-c2cccnc2OC)c(C)c1>>COc1ncccc1-c1ccc(C(=O)O)cc1C,,CCO,O,[Na+].[OH-],,val
US20100137587A1,CCOC(=O)c1nccn1CCCCOC.O=C1CCC(=O)N1Br>>CCOC(=O)c1nc(Br)cn1CCCCOC,,CC#N,,,,val
US05334576,COC(=O)c1cc(CCCl)c(Cl)nc1C(=O)OC>>COC(=O)c1cc(CCCl)cnc1C(=O)OC,[Pd],CO,,CC(=O)[O-].[Na+],,val
US20050256201A1,BrCCc1ccc(OCCOCc2ccccc2)cc1>>OCCOc1ccc(CCBr)cc1,[Pd],CCO,CCOC(C)=O,,,val
US20090239810A1,CC(C)(C)OC(=O)N1CCC(OS(C)(=O)=O)CC1.Sc1ccccc1Br>>CC(C)(C)OC(=O)N1CCC(Sc2ccccc2Br)CC1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04116956,CCOC(C)([O-])[O-].NNC1=Nc2ccc(C(F)(F)F)cc2C(c2ccccc2)=NC1>>Cc1nnc2n1-c1ccc(C(F)(F)F)cc1C(c1ccccc1)=NC2,,ClC(Cl)Cl,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20100261696A1,CC(C)(C)OC(=O)N1CC(C#N)C1.Cn1cnc(S(=O)(=O)Cl)c1>>Cn1cnc(S(=O)(=O)N2CC(C#N)C2)c1,,C1COCCO1,,CCN(C(C)C)C(C)C,Cl,val
US06207686B1,O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)C(Cc1ccccc1OCc1ccccc1)C(O)C1CCCCC1>>O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(Cc1ccccc1O)C(O)C1CCCCC1,[Pd],CO,,,,val
US20060235033A1,COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.C[C@H](N)c1ccc(Br)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)N[C@@H](C)c4ccc(Br)cc4)cc3)c2cc1OC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20090029965A1,CC(N)=S.O=C1c2ccccc2N(C(=O)c2ccccc2)CCC1Br>>Cc1nc2c(s1)CCN(C(=O)c1ccccc1)c1ccccc1-2,,CCO,,,,val
US20130225620A1,Cc1ccc(S(=O)(=O)n2ccc3c(CNc4nccc(Nc5cc(C6CC6)[nH]n5)n4)cccc32)cc1>>c1cc(CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)c2cc[nH]c2c1,,CO,,[K+].[OH-],,val
US20120214847A1,CC[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CC[C@@]2(O)CCc1nccc(OC)c1C(F)C(=O)O.N>>CC[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CC[C@@]2(O)CCc1nccc(OC)c1C(F)C(N)=O,,CCOC(C)=O,CN(C)C=O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05646173,CC=CCC1Cc2ccc(Br)cc2C1=O.O=[O+][O-]>>O=CCC1Cc2ccc(Br)cc2C1=O,,CO,ClCCl,,,val
US20070270422A1,CCOC(=O)CNc1cc(F)c(O)cc1F.CI.O=[N+]([O-])c1ccc(Cl)nc1>>CCOC(=O)C(C)Nc1cc(F)c(Oc2ccc([N+](=O)[O-])cn2)cc1F,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US05079235,CC#Cc1cn([C@H]2C[C@H](OC(C)=O)[C@@H](COC(C)=O)O2)c(=O)nc1-n1cncn1>>CC#Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)nc1N,,C1COCCO1,O,,,val
US20120101127A1,N#Cc1ccc(N)cc1.O=Cc1ccccc1[N+](=O)[O-]>>N#Cc1ccc(N=Cc2ccccc2[N+](=O)[O-])cc1,,CCO,,,,val
US20110311474A1,Cc1ccc(S(=O)(=O)n2ccc3c2ncc2ncc(C4CC(N(Cc5ccccc5)Cc5ccccc5)CC4C)n23)cc1>>CC1CC(N(Cc2ccccc2)Cc2ccccc2)CC1c1cnc2cnc3[nH]ccc3n12,,C1COCCO1,,[Na+].[OH-],,val
US04394382,COc1cc(O)c2c(c1)CC(CO)CO2.CS(=O)(=O)Cl>>COc1cc(O)c2c(c1)CC(COS(C)(=O)=O)CO2,,c1ccncc1,,,,val
US20130150343A1,CC(C)(C)c1cc(N)[nH]n1.Ic1cnn(CCOC2CCCCO2)c1>>CC(C)(C)c1cc(N)n(-c2cnn(CCOC3CCCCO3)c2)n1,[Cu]I,Cc1ccccc1,O,CN[C@@H]1CCCC[C@H]1NC,O=C([O-])[O-].[K+].[K+],val
US05177263,C=CCNCC(OC)OC.CC(=O)Cl>>C=CCN(CC(OC)OC)C(C)=O,,Cc1ccccc1,,[Na+].[OH-],,val
US05162311,CCOC(=O)C(N)Cc1cc(CP(=O)(OCC)OCC)cc(-c2ccc(Cl)cc2)c1>>CCOP(=O)(Cc1cc(CC(N)C(=O)O)cc(-c2ccc(Cl)cc2)c1)OCC,,C1CCOC1,,[Na+].[OH-],,val
US20140235660A1,COc1ccc(-c2sc3cc(OC)ccc3c2Oc2ccc(/C=C/C(=O)OC(C)(C)C)cc2)cc1>>COc1ccc(-c2sc3cc(OC)ccc3c2Oc2ccc(CCC(=O)OC(C)(C)C)cc2)cc1,[Pd],ClCCl,,CO,,val
US20120277229A1,O=C(Nc1ccc2c(c1)c(-c1nc3ccccc3[nH]1)nn2C1CCCCO1)c1cccc(F)c1>>O=C(Nc1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1)c1cccc(F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140303164A1,Cn1nc(NS(C)(=O)=O)c2cccc(-c3ccc(C#CC(C)(C)O)nc3[C@H](Cc3cc(F)cc(F)c3)NC(=O)OC(C)(C)C)c21>>Cn1nc(NS(C)(=O)=O)c2cccc(-c3ccc(C#CC(C)(C)O)nc3[C@@H](N)Cc3cc(F)cc(F)c3)c21,,ClCCl,,C1COCCO1,Cl,val
US20090042925A1,CC(C)(C)OC(=O)NCCCn1c(CCl)nc2cnc3cccnc3c21.O=C1c2ccccc2C(=O)N1O>>CC(C)(C)OC(=O)NCCCn1c(CON2C(=O)c3ccccc3C2=O)nc2cnc3cccnc3c21,,CN(C)C=O,O,CCN(CC)CC,,val
US04079081,NCC=C(c1ccc(-c2ccccc2)cc1)c1ccc(-c2ccccc2)cc1.O=CO>>O=CNCC=C(c1ccc(-c2ccccc2)cc1)c1ccc(-c2ccccc2)cc1,,O=CO,,CC(=O)OC(C)=O,,val
US20040106667A1,N#Cc1n[nH]c2ccc(N)cc12.O=S(=O)(Cl)c1cccc(F)c1>>N#Cc1n[nH]c2ccc(NS(=O)(=O)c3cccc(F)c3)cc12,,c1ccncc1,,,,val
US20100324092A1,CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2)nc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1>>CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2)nc1NC(=O)c1ccc(CN)cc1,[Pd],CCO,,O=CO,,val
US20080305037A1,CCC(Oc1cc(C)c(S(=O)(=O)Cl)c(C)c1)C(=O)O.COC(=O)[C@@H](N)CNC(=O)OC(C)(C)C>>COC(=O)C(CNC(=O)OC(C)(C)C)NS(=O)(=O)c1c(C)cc(OCCCC(=O)O)cc1C,,C1COCCO1,,Cl,O=C([O-])O.[Na+],val
US20100087506A1,CC[C@@H]1N(C(=O)OCc2ccccc2)CC[C@@]1(O)CC>>CC[C@@H]1NCC[C@@]1(O)CC,[Pd],O,,,,val
US20070197635A1,CC1(CCCC(=O)COC2C(=O)CCC3(C)C(=O)CCC23)OCCO1>>CC1(CCC2=C3CCC4(C)C(=O)CCC4C3OCC2=O)OCCO1,,Cc1ccccc1,,CO,C[O-].[Na+],val
US20040044012A1,COc1ccc(N)cc1.CS(=O)c1ncc2c(n1)N(C1CCCC1)C(=O)NC2>>COc1ccc(Nc2ncc3c(n2)N(C2CCCC2)C(=O)NC3)cc1,,CCOC(C)=O,,CS(C)=O,,val
US04607041,CCOC(=O)C=C(C)N.COC(=O)C(=Cc1cccc(Cl)c1Cl)C(=O)c1ccccc1>>CCOC(=O)C1=C(C)NC(c2ccccc2)=C(C(=O)OC)C1c1cccc(Cl)c1Cl,,CC(C)(C)O,,N,,val
US05932599,CC(=O)Nc1ccc(S(N)(=O)=O)cc1.CCNc1nc(Cl)cc(Cl)n1>>CCNc1nc(Cl)cc(NS(=O)(=O)c2ccc(NC(C)=O)cc2)n1,,CN1CCCC1=O,,[K],,val
US20030013715A1,C[C@H]1CC[C@H](N)CC1.Cl.ClCCl.O=C(Cl)c1cnc2ccccc2n1.c1ccncc1>>Cl.Cl.O=C(Nc1cnc2ccccc2c1)c1cnc2ccccc2n1,,CCOCC,,,,val
US20100048581A1,CC(C)(C)CNCC(CNC(=O)OC(C)(C)C)(c1ccccc1)c1ccccc1>>CC(C)(C)CNCC(CN)(c1ccccc1)c1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020156081A1,Cn1ccnc1C(=O)O.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CNC1>>Cn1ccnc1CN1CC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100240725A1,COc1ccc(C2(CCCO[Si](C)(C)C(C)(C)C)OCc3cc(C#N)ccc32)cc1>>COc1ccc(C2(CCCO)OCc3cc(C#N)ccc32)cc1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04731374,Br.Br.CC(=O)NC1CCc2nc(N)sc2C1>>Br.Br.Nc1nc2c(s1)CC(N)CC2,,Br,,,,val
US20070254957A1,CCO.O=C(O)Cc1cc(OCc2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)c1>>CCOC(=O)Cc1cc(O)cc(-c2ccc(C(F)(F)F)cc2)c1,[Pd],,,,,val
US20100280011A1,CC(C)[Si](OCc1ccc(C(CNC(=O)OC(C)(C)C)C(=O)O)cc1)(C(C)C)C(C)C.CI>>CC(C)[Si](OCc1ccc(C(CN(C)C(=O)OC(C)(C)C)C(=O)O)cc1)(C(C)C)C(C)C,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20120149737A1,COC(=O)c1ccc(NC(=O)c2cc(Cl)c(OCc3ccccc3)c(OC3CCCCC3)c2)cc1>>COC(=O)c1ccc(NC(=O)c2cc(Cl)c(O)c(OC3CCCCC3)c2)cc1,,O=C(O)C(F)(F)F,,Br,CC(=O)O,val
US20080064872A1,C=CN1CCCC1.CCOC(=O)c1nnc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1>>CCOC(=O)c1ccc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1,,ClC(Cl)Cl,,,,val
US20030199440A1,CC(C)(C)OC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1>>O=C(O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1,,Cl,,O,,val
US05071859,CCOC(=O)[C@@H]1CCCN(CCOC=C(c2ccccc2)c2ccccc2)C1.Cl>>Cl.O=C(O)[C@@H]1CCCN(CCOC=C(c2ccccc2)c2ccccc2)C1,,CCO,,ClCCl,[Na+].[OH-],val
US05236952,COc1cc(C(=O)Cl)cc([N+](=O)[O-])c1OC.NCCc1ccccc1>>COc1cc(C(=O)NCCc2ccccc2)cc([N+](=O)[O-])c1OC,,ClCCl,,CCN(CC)CC,,val
US20100305133A1,COC(=O)c1c(OC)ccc2nc(NCc3ccccc3)c(-c3ccccc3)nc12>>O=C(O)c1c(O)ccc2nc(NCc3ccccc3)c(-c3ccccc3)nc12,,ClCCl,,BrB(Br)Br,,val
US20090176770A1,O=C(O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)OC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1>>O=C(O)[C@@H](Cc1ccc(O)cc1)OC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1,[Pd],CO,,CCN(CC)CC,,val
US20060229294A1,COC(=O)c1ccc(C(=O)O)nc1.NCCNc1nsc2ccccc12>>COC(=O)c1ccc(C(=O)NCCNc2nsc3ccccc23)nc1,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US06191124B1,CC(=O)c1cnc2sc(C)c(C)n12.O=Cc1ccccc1>>Cc1sc2ncc(C(=O)/C=C/c3ccccc3)n2c1C,,C1CCOC1,,C[O-].[Na+],,val
US20090227619A1,CCC=O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O>>CCC1NC(C(=O)O)Cc2c1[nH]c1ccccc21,,O,,O=S(=O)(O)O,,val
US20050080124A1,COc1ccc(N)cc1-c1c(Br)cnn1C.O=C=Nc1ccc2ccccc2c1>>COc1ccc(NC(=O)Nc2ccc3ccccc3c2)cc1-c1c(Br)cnn1C,,ClCCl,,,,val
US04931444,CI.COc1ccc(N2CCN(c3ccc(NC4=NC(C)(C)CS4)cc3)CC2)cc1>>COc1ccc(N2CCN(c3ccc(N=C4SCC(C)(C)N4C)cc3)CC2)cc1,,O,,CN(C)C=O,[H-].[Na+],val
US20150225397A1,Cc1nc(-c2cnn(CCO)c2)c2c(n1)[C@@]1(c3ccccc3)Cc3cnoc3[C@@H](C)[C@@H]1CC2>>Cc1nc(-c2cnn(CCO)c2)c2c(n1)[C@@]1(c3ccccc3)CC(C#N)C(=O)[C@@H](C)[C@@H]1CC2,,C1CCOC1,CO,Cl,C[O-].[Na+],val
US20110269705A1,CCCOc1cc2ccccc2c2c(=O)c(-c3ccoc3)c[nH]c12.CI>>CCCOc1cc2ccccc2c2c(=O)c(-c3ccoc3)cn(C)c12,,CCOC(C)=O,O,CN(C)C=O,[H-].[Na+],val
US20140018313A1,CC(C)(C)OC(=O)N1C2CCC(C2)C1c1ncc(-c2ccc3c(c2)CCc2cc(B4OC(C)(C)C(C)(C)O4)ccc2-3)[nH]1.COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(Br)[nH]1)C(C)C>>COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3c(c2)CCc2cc(-c4cnc([C@@H]5[C@H]6CC[C@H](C6)N5C(=O)OC(C)(C)C)[nH]4)ccc2-3)[nH]1)C(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])O.[Na+],,val
US20160214971A1,COc1nccc(C)c1B(O)O.Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Cl)c(Cl)c1>>COc1nccc(C)c1-c1ncc(-c2cc(F)c(C(=O)NS(C)(=O)=O)cc2C)cc1Cl,,O,,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20150065522A1,CCc1c(C)nc2c(Br)cnn2c1Cl.CO>>CCc1c(C)nc2c(Br)cnn2c1OC,,CO,,C[O-].[Na+],,val
US20110144105A1,Cc1ccc(S(=O)(=O)OC(=CC2CCCC2)c2cc3cccnc3n2S(=O)(=O)c2ccccc2)cc1.OB(O)c1ccc2c(c1)OCCO2>>O=S(=O)(c1ccccc1)n1c(C(=CC2CCCC2)c2ccc3c(c2)OCCO3)cc2cccnc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20160068559A1,CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21)C(=O)CCCc1nc2cc(C(C)(C)C)ccc2[nH]1>>CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)C(=O)CCCc1nc2cc(C(C)(C)C)ccc2[nH]1,,O=C(O)C(F)(F)F,,,,val
US20090156642A1,Fc1cccc(S)c1.O=Cc1cc(Br)c(Br)s1>>O=Cc1cc(Br)c(Sc2cccc(F)c2)s1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20050176767A1,COC(=O)c1nc(Br)cc(Br)c1OCc1ccccc1.OCc1ccccc1>>COC(=O)c1nc(Br)cc(OCc2ccccc2)c1OCc1ccccc1,,CCOCC,CN(C)C=O,[H-].[Na+],,val
US20090082367A1,CCOC(=O)CCn1c(C2CC2)nnc1C(C)(C)c1ccc(Br)s1.Cl>>CC(C)(c1ccc(Br)s1)c1nnc(C2CC2)n1CCC(=O)O.Cl,,CCO,,[Na+].[OH-],,val
US20110028442A1,CC1(Cc2cccc([N+](=O)[O-])c2)OCCO1>>CC1(Cc2cccc(N)c2)OCCO1,[Pd],CO,,,,val
US20060004017A1,O=[N+]([O-])c1ccc(Cl)c(C(F)(F)F)c1.OCc1ccccc1>>O=[N+]([O-])c1ccc(OCc2ccccc2)c(C(F)(F)F)c1,,CC(=O)N(C)C,ClCCl,CC(=O)O,[H-].[Na+],val
US20150291563A1,CC(=O)c1cccc(-c2cccc(C3CC(C(O)(C(F)(F)F)C(F)(F)F)=NN3c3ccccc3Cl)c2)c1.C[Mg]Cl>>CC(C)(O)c1cccc(-c2cccc(C3CC(C(O)(C(F)(F)F)C(F)(F)F)=NN3c3ccccc3Cl)c2)c1,,C1CCOC1,,,,val
US20140275080A1,O=[N+]([O-])c1ccc(Oc2ccnc(Cl)c2)cn1.OB(O)c1ccnc(C(F)(F)F)c1>>O=[N+]([O-])c1ccc(Oc2ccnc(-c3ccnc(C(F)(F)F)c3)c2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US04925861,CC(=O)O.CC(C)c1csc(C=Cc2cccc(C#N)c2)n1>>CC(C)c1csc(C=Cc2cccc(C(=O)O)c2)n1,,Cl,,O,,val
US20070060607A1,ClCc1ccc(Cl)cc1.Oc1ccc(Cl)c(O)c1>>Oc1cc(OCc2ccc(Cl)cc2)ccc1Cl,,CC#N,,[F-].[K+],,val
US04421758,Cc1ccc(S(=O)(=O)OC[C@H]2CCC[C@H](OCc3c(Cl)cccc3Cl)O2)cc1.c1c[nH]cn1>>Clc1cccc(Cl)c1CO[C@H]1CCC[C@H](Cn2ccnc2)O1,,CN(C)C=O,,[H-].[Na+],,val
US20140194431A1,CC(C)(C)[Si](C)(C)OCCNC1CCCC1.O=C(O)c1nc(CC2(c3ccccc3)CCCC2)nc(O)c1OCc1ccccc1>>CC(C)(C)[Si](C)(C)OCCN(C(=O)c1nc(CC2(c3ccccc3)CCCC2)nc(O)c1OCc1ccccc1)C1CCCC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140107157A1,Cc1c(C(=O)NC2CCN(C(=O)Oc3ccc([N+](=O)[O-])cc3)CC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1>>CCOC(=O)N1CCC(NC(=O)c2nn(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)c2C)CC1,,C1CCOC1,,[H-].[Na+],,val
US20080188467A1,BrCc1ccccc1.Cc1cc(C#N)cc(C)c1O>>Cc1cc(C#N)cc(C)c1OCc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20050277652A1,Nc1ccc(Oc2ccnc(NC(=O)N3CCC(CN4CCC4)CC3)c2)c(F)c1.O=C=NC(=O)Cc1ccccc1>>O=C(Cc1ccccc1)NC(=O)Nc1ccc(Oc2ccnc(NC(=O)N3CCC(CN4CCC4)CC3)c2)c(F)c1,,CCCCCC,CN(C)C=O,CCOCC,,val
US20140256707A1,COc1ccc(CN(c2ncns2)S(=O)(=O)c2ccc3c(-c4ccc(C(F)(F)F)cc4-c4ccnn4C)cn(C)c3c2)c(OC)c1.Cl>>Cn1nccc1-c1cc(Cl)ccc1-c1cn(C)c2cc(S(=O)(=O)Nc3ncns3)ccc12,,CO,,,,val
US20080004285A1,COC(=O)CC(=O)N1CCN(c2nc(N)nc3ccc(-c4ccc(F)cc4)nc23)CC1.Nc1ccc(Cl)cc1>>Nc1nc(N2CCN(C(=O)CC(=O)Nc3ccc(Cl)cc3)CC2)c2nc(-c3ccc(F)cc3)ccc2n1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20100093730A1,CC(C)(C)OC(=O)NC1CCNCC1.O=Cc1cccc(C(F)(F)F)c1>>CC(C)(C)OC(=O)NC1CCN(Cc2cccc(C(F)(F)F)c2)CC1,CC(=O)O,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20050014788A1,OCCC(c1ccccc1)c1ccc(-c2ccccc2)cc1>>O=CCC(c1ccccc1)c1ccc(-c2ccccc2)cc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20050165008A1,Nc1ccc(Cl)cc1S(N)(=O)=O.O=C(Cl)C(F)F>>NS(=O)(=O)c1cc(Cl)ccc1NC(=O)C(F)F,,C1COCCO1,,c1ccncc1,,val
US05756519,C=CC(=O)OCC.Nc1ccc(C(=O)O)cc1>>CCOC(=O)CCNc1ccc(C(=O)O)cc1,,CC(=O)O,,,,val
US20110281838A1,CCc1nc(N)nc(-c2ccc(C(=O)OC)c(F)c2)c1C#Cc1ccc(NC)nc1>>CCc1nc(N)nc(-c2ccc(C(=O)O)c(F)c2)c1C#Cc1ccc(NC)nc1,,C1CCOC1,,,,val
US20100179128A1,CCCCCn1c(=O)n(CCCCC(=O)O)c(=O)c2[nH]c(Cl)nc21.CCc1cccc(CN)c1>>CCCCCn1c(=O)n(CCCCC(=O)NCc2cccc(CC)c2)c(=O)c2[nH]c(Cl)nc21,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20050239780A1,Cc1ccc([C@@H](C(=O)OC(C)(C)C)C2CCOCC2)cc1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)[C@H](c1ccc(CBr)cc1)C1CCOCC1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20040127509A1,Fc1cccc(Cl)c1-c1c(Cl)nc2ncnn2c1Cl.NCCCC(F)(F)F>>Nc1nc2nc(Cl)c(-c3c(F)cccc3Cl)c(CCCC(F)(F)F)n2n1,,ClCCl,,CCN(CC)CC,,val
US04007202,C=C(C)C(C(=O)O)N1C(=O)C(NC(=O)Cc2ccccc2)C1SN1C(=O)CCC1=O.C=[N+]=[N-]>>C=C(C)C(C(=O)OC)N1C(=O)C(NC(=O)Cc2ccccc2)C1SN1C(=O)CCC1=O,,CCOCC,,,,val
US20040147580A1,CN(C)C=O.Cc1cn(C)c2ccccc12>>Cc1c(C=O)n(C)c2ccccc12,,O,,O=P(Cl)(Cl)Cl,[Na+].[OH-],val
US04562206,CCOC(=O)C(Cc1cccc(C#N)c1)C(C)=O>>CC(=O)CCc1cccc(C(N)=O)c1,,Cl,,O,,val
US04892962,C=CCC(F)(F)C(=O)[O-].CO[Na]>>C=CCC(F)(F)C(=O)[O-].[Na+],,CO,,,,val
US04680054,CC(=O)Cl.COc1ccccc1Cl>>COc1ccc(C(C)=O)cc1Cl,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US04248620,CN1C(=O)C(=NC(Cl)C(Br)(Br)CCl)N(c2ccccc2F)C1=O.Nc1ccccc1Br>>CN1C(=O)C(=NC(Nc2ccccc2Br)C(Br)(Br)CCl)N(c2ccccc2F)C1=O,,CC#N,CCOCC,CCN(CC)CC,Cl,val
US06066639,C#Cc1cnc2nc(NC(=O)C(C)(C)C)nc(O)c2c1.COC(=O)CC[C@H](NC(=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(I)n1)C(=O)OC>>COC(=O)CC[C@H](NC(=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(C#Cc2cnc3nc(NC(=O)C(C)(C)C)nc(O)c3c2)n1)C(=O)OC,,CC#N,,CCN(CC)CC,,val
US20130267546A1,CCCCCCCCCBr.Cc1nc(-n2c(C)ccc2C)nc(C)c1OCc1ccccc1>>CCCCCCCCCCc1nc(-n2c(C)ccc2C)nc(C)c1OCc1ccccc1,,C1CCOC1,CCCCC,[Li]CCCC,,val
US20050038035A1,CC(=O)Nc1cccc(CCc2ccc(NC(=O)c3ccc(C)cc3-c3ccc(C(F)(F)F)cc3)cc2)n1>>Cc1ccc(C(=O)Nc2ccc(CCc3cccc(N)n3)cc2)c(-c2ccc(C(F)(F)F)cc2)c1,,CO,,Cl,,val
US20100184979A1,CC(C)(C(=O)O)c1cccc(B(O)O)c1.COc1nc(Cl)cc(Cl)n1>>CC(C)(C(=O)O)c1cccc(-c2cc(Cl)nc(O)n2)c1,[Pd],,,,,val
US20140045825A1,CNCCNC.Cc1cccc2cc(CNc3ncnc4[nH]cnc34)c(Cl)nc12>>CNCCN(C)c1nc2c(C)cccc2cc1CNc1ncnc2[nH]cnc12,,CC(=O)N(C)C,,,,val
US06127414,CSC(=NC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1.Cl.NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CO)c1ccccc1>>Cl.N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CO)c1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20090023763A1,CSc1nccc(/C(=C/N(C)C)C(=O)c2ccco2)n1.N#CCC(N)=O>>CSc1nccc(-c2cc(C#N)c(=O)[nH]c2-c2ccco2)n1,,CN(C)C=O,,C[O-].[Na+],,val
US20150141406A1,COc1ncc(C#N)c2c(C3=CCCC3)cn(COCC[Si](C)(C)C)c12>>COc1ncc(C#N)c2c(C3CCCC3)cn(COCC[Si](C)(C)C)c12,[Pd],CO,,,,val
US20090042900A1,CCOC(=O)C1CCC(Oc2c(F)cccc2F)CC1>>OCC1CCC(Oc2c(F)cccc2F)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05300716,C#CCCCCC.C#CCOS(=O)(=O)c1ccc(C)cc1>>C#CCC#CCCCCC,Cl[Cu],O,,,,val
US20100004238A1,CC(C)(C)OC(=O)N1CC[C@@H](O)[C@H](N=[N+]=[N-])C1.Cl>>Cl.[N-]=[N+]=N[C@@H]1CNCC[C@H]1O,,CCOC(C)=O,,,,val
US20140142307A1,Br.BrCCc1cccc2ccccc12.Clc1nc[nH]c1Cl.O=C(O)COc1ccc(CBr)cc1>>O=C(O)COc1ccc(Cn2c[n+](CCc3cccc4ccccc34)c(Cl)c2Cl)cc1.[Br-],,CC#N,,[K+].[OH-],,val
US20050070580A1,FC(F)C(=S)OCCC(c1ccccc1)c1ccccc1.NCC1CN(c2ccc(N3C=CC(=O)CC3)c(F)c2)C(=O)O1>>O=C1C=CN(c2ccc(N3CC(CNC(=S)C(F)F)OC3=O)cc2F)CC1,,CC#N,CN(C)C=O,,,val
US20140010783A1,Nc1cc(F)c(Br)c(F)c1.S=C(Cl)Cl>>Fc1cc(N=C=S)cc(F)c1Br,,ClCCl,,O=C([O-])[O-].[Ca+2],,val
US20050038068A1,CCOC(=O)c1c(C=O)csc1NC(=O)OC(C)(C)C.COP(=O)(OC)C(=[N+]=[N-])C(C)=O>>C#Cc1csc(NC(=O)OC(C)(C)C)c1C(=O)OCC,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US05378720,CC(C)c1cccc2c1C(=O)N(CSc1ccccc1)S2(=O)=O.O=S(=O)(Cl)Cl>>CC(C)c1cccc2c1C(=O)N(CCl)S2(=O)=O,,ClCCl,,,,val
US05696148,CCOC(=O)CC#N.O=Cc1c(Cl)n(Cc2ccccc2)c2ccccc12>>CCOC(=O)C(C#N)=Cc1c(Cl)n(Cc2ccccc2)c2ccccc12,,O,,CCN(CC)CC,CCO,val
US20040044024A1,CCOC(=O)CC(=O)OCC.CCOC(=O)c1cnn(C)c1N>>CCOC(=O)c1c(O)c2cnn(C)c2[nH]c1=O,,CCO,O,[Na],,val
US20150203511A1,COc1cc(C)c(-c2cc(C(F)(F)F)n(C)n2)cc1C>>Cc1cc(-c2cc(C(F)(F)F)n(C)n2)c(C)cc1O,,CC(=O)O,,Br,,val
US20140275080A1,CC(C)OC(=O)C1(C(=O)OC(C)C)CC2(CCC2)C1>>O=C(O)C1(C(=O)O)CC2(CCC2)C1,,CO,,[Na+].[OH-],,val
US20150119380A1,CCOC(=O)CC(C)=O.O=Cc1ccc(F)cc1O>>CC(=O)c1cc2ccc(F)cc2oc1=O,C1CCNCC1,,,,,val
US09428503B2,CO[C@H]1C[C@@H](Nc2c(C(=O)O)cnc3ccc(Br)cc23)C1.[N-]=[N+]=NP(=O)(Oc1ccccc1)Oc1ccccc1>>CO[C@@H]1C[C@H](n2c(=O)[nH]c3cnc4ccc(Br)cc4c32)C1,,CN(C)C=O,,CCN(CC)CC,O,val
US20020132822A1,CCOC(=O)CC(=O)OCC.CCOCCBr.NC(N)=O>>CCOCCC1C(=O)NC(=O)NC1=O,,CCO,,Cl,[Na],val
US05112988,Cl.O=C1CCC(c2ccccc2F)(c2ccccc2F)C2CN(Cc3ccccc3)CC12>>Cl.O=C1CCC(c2ccccc2F)(c2ccccc2F)C2CNCC12,,CO,,C,,val
US20030162806A1,Cc1nc(Cl)c([N+](=O)[O-])c(NCCNC(=O)OC(C)(C)C)c1C.Oc1ccccc1>>Cc1nc(Oc2ccccc2)c([N+](=O)[O-])c(NCCNC(=O)OC(C)(C)C)c1C,,COCCOCCOC,,O,[H-].[Na+],val
US20100137299A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1Nc2ccccc2C12COc1cc3c(cc12)OCCO3>>CC(C)(C)OC(=O)N1C(=O)C2(COc3cc4c(cc32)OCCO4)c2ccccc21,CN(C)c1ccncc1,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20100016319A1,CC(C)(C)c1cc(NC(=O)NCc2ccccc2O)n(-c2cccc(S(=O)(=O)C(F)(F)F)c2)n1.Clc1ccnc(Cl)n1>>CC(C)(C)c1cc(NC(=O)NCc2ccccc2Oc2ccnc(Cl)n2)n(-c2cccc(S(=O)(=O)C(F)(F)F)c2)n1,,CC(C)=O,,[Na+].[OH-],[Cl-].[NH4+],val
US20030134885A1,CN(Cc1cccc(Br)c1)C(=O)OC(C)(C)C.O=Cc1ccc(B(O)O)cc1>>CN(Cc1cccc(-c2ccc(C=O)cc2)c1)C(=O)OC(C)(C)C,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US06436925B1,CCOC(=O)c1cccc(N)c1.O=S(=O)(Cl)c1ccc2ccccc2c1>>CCOC(=O)c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1,,C1CCOC1,,CCN(CC)CC,,val
US20090048230A1,C=O.N#Cc1nc(NCC2CCC3(CC2)CC3)c(C(=O)NCc2ccccc2)c(OCCC2CCNCC2)n1>>CN1CCC(CCOc2nc(C#N)nc(NCC3CCC4(CC3)CC4)c2C(=O)NCc2ccccc2)CC1,,C1CCOC1,,[BH3-]C#N.[Na+],,val
US20090048228A1,Brc1c[nH]c(Br)n1.C[Si](C)(C)CCOCCl>>C[Si](C)(C)CCOCn1cc(Br)nc1Br,,C1CCOC1,,[H-].[Na+],,val
US20040106653A1,CCOC(=O)CBr.O=S(=O)(c1ccc(CCCN(Cc2ccccc2)C[C@H](O)c2cccc(Cl)c2)cc1)c1cccc(O)c1>>CCOC(=O)COc1cccc(S(=O)(=O)c2ccc(CCCN(Cc3ccccc3)C[C@H](O)c3cccc(Cl)c3)cc2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050004143A1,Fc1ccc(Cl)cc1-c1nc(Cl)c2c(n1)CCO2.I>>Fc1ccc(Cl)cc1-c1nc(I)c2c(n1)CCO2,,O,,[I-].[Na+],,val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2cc(C)c(O[C@H]3CCC(F)(F)C[C@@H]3c3ccnn3C)cc2F)c(OC)c1>>Cc1cc(S(=O)(=O)Nc2ccncn2)c(F)cc1O[C@H]1CCC(F)(F)C[C@@H]1c1ccnn1C,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US06355653B1,N=C(CS(=O)(=O)c1ccccc1)NNC(=O)c1cccs1>>O=S(=O)(Cc1n[nH]c(-c2cccs2)n1)c1ccccc1,,CCO,,,,val
US04603128,CC(=O)OCC(=O)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C.CC(=O)S>>CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H](C(=O)CO)CC[C@H]3[C@@H]21,,ClCCl,,CO,O=C([O-])[O-].[K+].[K+],val
US05047420,COc1cc(C(CCC(C(=O)O)c2cc(OC)c(OC)c(OC)c2)C(=O)O)cc(OC)c1OC>>COc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)C2=O)cc(OC)c1OC,,CC(=O)OC(C)=O,,,,val
US04739113,CCOC(=O)C(=O)CCCCCCCCC(=O)C(=O)OCC>>O=C(O)C(=O)CCCCCCCCC(=O)C(=O)O,,[K+],[OH-],Cl,,val
US20070179122A1,COC(=O)c1cc(F)ccc1[N+](=O)[O-].Oc1ccccn1>>COC(=O)c1cc(-n2ccccc2=O)ccc1[N+](=O)[O-],,CN(C)C=O,,O,,val
US20140010783A1,CNS(=O)(=O)c1ccc(N/C(=N/C#N)SC)cc1.NN>>CNS(=O)(=O)c1ccc(Nc2n[nH]c(N)n2)cc1,,CCO,,,,val
US20130109708A1,CCOC(=O)c1cc(F)c(COc2cnc(OC)c(Cl)c2)cc1F>>COc1ncc(OCc2cc(F)c(C(=O)O)cc2F)cc1Cl,,C1CCOC1,,Cl,[Li+].[OH-],val
US20110190255A1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CCOC(=O)[C@H]1CCCN(C[C@@H](O)c2ccc(C#N)cc2)C1>>CCOC(=O)[C@H]1CCCN(C[C@@H](O[Si](C)(C)C(C)(C)C)c2ccc(C#N)cc2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20050119247A1,CCOC(=O)C(CCC1(C(=O)N[C@H]2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)CCCC1)CC(=O)O.CO.COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1>>CCOC(=O)C(CC(=O)NC(C)C)CC1(C(=O)N[C@H]2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)CCCC1,,CO,,Cl,,val
US20100087427A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2O)C(C)C)ccc1OC.COc1ccc(CN=C=O)cc1>>COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2OC(=O)NCc2ccc(OC)cc2)C(C)C)ccc1OC,,O,,CC#N,CC#N,val
US20090042892A1,C1CCNC1.CCOC(=O)C(=O)CBr.Nc1ccccc1C=O>>CCOC(=O)c1nc2ccccc2cc1N,,CCO,,c1ccncc1,,val
US20140057937A1,Fc1ccc(-n2ncc3c2CCCN3)cc1.O=C(O)Cc1ccc(OC(F)(F)F)cc1>>O=C(Cc1ccc(OC(F)(F)F)cc1)N1CCCc2c1cnn2-c1ccc(F)cc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US07109225B2,CCO[C@H](C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1)[C@H](O)c1ccc(OCCc2nc(C(C)(C)C)oc2C)c2ccccc12>>CCO[C@@H](Cc1ccc(OCCc2nc(C(C)(C)C)oc2C)c2ccccc12)C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US05419966,COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.OCCCCCCO>>COc1ccc(C(OCCCCCCO)(c2ccccc2)c2ccc(OC)cc2)cc1,,c1ccncc1,,CCN(C(C)C)C(C)C,,val
US20110034433A1,CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(C)=O)NC(=O)N1c1cccc(C(F)(F)F)c1.CS(=O)(=O)Cl>>CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(C)=O)N(S(C)(=O)=O)C(=O)N1c1cccc(C(F)(F)F)c1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20160002266A1,CCOC(=O)C=C1COC1.C[Mg]Cl>>CCOC(=O)CC1(C)COC1,[Cu]I,C1CCOC1,,C[Si](C)(C)Cl,,val
US04446325,CC(=O)CC(=O)OCC1(C)OCCO1.N>>C/C(N)=C/C(=O)OCC1(C)OCCO1,,CO,,,,val
US20060223801A1,CC(C)(C)OC(=O)NC1CCN(c2cc(C#N)cc(Cl)n2)CC1.NO>>CC(C)(C)OC(=O)NC1CCN(c2cc(C(N)=NO)cc(Cl)n2)CC1,,CO,,Cl,,val
US20110105460A1,CCOC(=O)CNC(=O)c1cc(Cl)ccc1OC(C)(C)c1nnc(-c2ccccc2C(F)(F)F)n1C.CN>>CNC(=O)CNC(=O)c1cc(Cl)ccc1OC(C)(C)c1nnc(-c2ccccc2C(F)(F)F)n1C,,CCO,O,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US04866070,CCOC(=O)c1ccc2nc3c(cc2c1)-c1cccc2cccc-3c12>>OCc1ccc2nc3c(cc2c1)-c1cccc2cccc-3c12,,O,,C1CCOC1,Cl,val
US20070219229A1,Nc1cccc(Cl)c1.O=C(NCC1CCOCC1)c1cnc(Cl)c2[nH]ccc12>>O=C(NCC1CCOCC1)c1cnc(Nc2cccc(Cl)c2)c2[nH]ccc12,,C1COCCO1,CO,CS(=O)(=O)O,,val
US20070205714A1,CC(=O)O.C[Mg]Cl.O=C1C(=O)c2cc(Br)ccc2-c2ccc(Br)cc21>>CC1(O)c2cc(Br)ccc2-c2ccc(Br)cc2C1(C)O,,C1CCOC1,CCOC(C)=O,,,val
US20070213336A1,CCCCCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)OCC)cc2)c1>>CCCCCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)O)cc2)c1,,CCO,,[Na+].[OH-],,val
US05780634,Cc1cccc2c(C(=O)O)cc(-c3ccccc3C(=O)O)nc12>>Cc1cccc2ccc(-c3ccccc3C(=O)O)nc12,,c1ccc2ncccc2c1,,O,[Na+].[OH-],val
US05326868,NC(=O)c1[nH]c2ccccc2c1NC(=O)c1ccccc1>>Oc1nc(-c2ccccc2)nc2c1[nH]c1ccccc12,,CCO,,[H-].[Na+],,val
US20100075953A1,CC(C)(C)OC(=O)N1CCN(c2ccc(OCCCN3CCCCC3)c(F)c2)CC1>>Fc1cc(N2CCNCC2)ccc1OCCCN1CCCCC1,,O=C(O)C(F)(F)F,,ClCCl,,val
US20080312192A1,CN1CCN(Cc2ccc(N)cc2C(F)(F)F)CC1.O=C=Nc1ccc(Oc2cc(Cl)ncn2)cc1>>CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(Cl)ncn4)cc3)cc2C(F)(F)F)CC1,,C1CCOC1,CCOCC,,,val
US20110178070A1,CC(=O)Nc1nc2ccc(-c3ccc4[nH]cc(C#N)c4c3)cc2s1.O=C(O)C(F)(F)F>>CC(=O)Nc1nc2ccc(-c3ccc4[nH]cc(C(N)=O)c4c3)cc2s1,,O=C(O)C(F)(F)F,,O=S(=O)(O)O,,val
US20030130349A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2c(Cl)cccc2Cl)cc1)C(=O)O.CC(C)COC(=O)Cl.CCOCC>>CCOC(=O)CCCc1ccccc1,,CCOCC,,CN1CCOCC1,,val
US20100173933A1,Cc1ccc2cccnc2c1.O=C1CCC(=O)N1Br>>BrCc1ccc2cccnc2c1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US06127361,COc1ccc(CCN2CCC[C@H](Cl)C2)cc1.c1ccc2c(c1)COc1ccccc1N2>>COc1ccc(CCN2CCC[C@@H]2CN2c3ccccc3COc3ccccc32)cc1,,CS(C)=O,,[H-].[Na+],,val
US20070032515A1,Cc1n[nH]c(N)c1-c1ccccc1.O=Cc1ccc(O)cc1>>Cc1n[nH]c2nc(-c3ccc(O)cc3)c3ccccc3c12,,CCOC(C)=O,,CS(=O)(=O)O,,val
US05955495,C#CCBr.Oc1cc(F)ccc1Br>>C#CCOc1cc(F)ccc1Br,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150225427A1,Cc1ccc(-n2nc([Si](C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)cc1.Nc1ccc2[nH]ncc2c1>>Cc1ccc(-n2nc([Si](C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)cc1,,CN(C)C=O,,,,val
US05464864,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#CCc1ccc2[nH]c3c(c2c1)CC(N)CC3>>CC(C)(C)OC(=O)NC1CCc2[nH]c3ccc(CC#N)cc3c2C1,,C1CCOC1,,,,val
US20060270706A1,COC(=O)Cn1nncc1/C=C1\CN(C(C(=O)C2CC2)c2ccccc2F)CCC1SC(C)=O.Cl>>COC(=O)Cn1nncc1/C=C1\CN(C(C(=O)C2CC2)c2ccccc2F)CCC1S.Cl,,CO,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20070072920A1,COCCc1cc(OC)c(C[C@@H](C)NC(=O)C(F)(F)F)cc1OC.Cl>>COCCc1cc(OC)c(C[C@@H](C)N)cc1OC.Cl,,CCOCC,CO,[Na+].[OH-],,val
US20070244092A1,CC(C)(C)c1nc2cc(S(=O)(=O)Cl)ccc2n1CC1CCC(F)(F)CC1.O=C(NC1CC1)C1CNCCO1>>CC(C)(C)c1nc2cc(S(=O)(=O)N3CCOC(C(=O)NC4CC4)C3)ccc2n1CC1CCC(F)(F)CC1,,ClCCCl,,CCN(C(C)C)C(C)C,,val
US20130261077A1,CCOC(=O)Cc1nnc(-c2ccc(I)cc2)o1>>O=C(O)Cc1nnc(-c2ccc(I)cc2)o1,,C1COCCO1,,Cl,[Na+].[OH-],val
US20060100262A1,COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(=O)N(CCN(C)C)Cc1cc(Cl)ccc1-3>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCN(CCN(C)C)Cc1cc(Cl)ccc1-3,,C1CCOC1,CO,B,Cl,val
US20160060258A1,Cc1cn(-c2c(Cl)cccc2Cl)c(=O)c2cnc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cc3)nc12>>Cc1cn(-c2c(Cl)cccc2Cl)c(=O)c2cnc(Nc3ccc(N4CCNCC4)cc3)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US05874427,Cc1nc(N)ccc1[N+](=O)[O-].O>>Cc1nc(O)ccc1[N+](=O)[O-],,O,,O=N[O-].[Na+],,val
US06803457B1,CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cc(Cl)ccc4OCC(=O)O)ncnc32)[C@H](O)[C@@H]1N=[N+]=[N-].O=C1CNCCN1>>CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cc(Cl)ccc4OCC(=O)N4CCNC(=O)C4)ncnc32)[C@H](O)[C@@H]1N=[N+]=[N-],CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US08039497B2,N#C[S-].NNc1ccc(Cl)c(Cl)c1>>NC(=S)NNc1ccc(Cl)c(Cl)c1,,O,,[K],,val
US05910506,CI.COc1ccc(COCc2nc(C(C)C)c(Sc3cc(Cl)cc(Cl)c3)[nH]2)cc1>>COc1ccc(COCc2nc(C(C)C)c(Sc3cc(Cl)cc(Cl)c3)n2C)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120101083A1,Cc1c(-c2noc(-c3cnc(NC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(=O)OC(C)(C)C)CC2.Cl>>Cc1c(-c2noc(-c3cnc(NC(C)C)c(C#N)c3)n2)ccc2c1CCNCC2.Cl,,C1COCCO1,CCOCC,,,val
US20100048537A1,O=C(OC(=O)C(F)(F)F)C(F)(F)F.OC1CCNCc2occc21>>O=C(N1CCC(O)c2ccoc2C1)C(F)(F)F,,ClCCl,,CCN(CC)CC,O,val
US20110224225A1,BrCc1ccccc1.O=C1NC2CCC1CC2>>O=C1C2CCC(CC2)N1Cc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20100076004A1,C[Si](C)(C)C#N.Nc1cccc(F)c1.O=C1CCN(Cc2ccccc2)CC1>>N#CC1(Nc2cccc(F)c2)CCN(Cc2ccccc2)CC1,,CC(=O)O,,[NH4+].[OH-],,val
US20040058894A1,CCCCCCCCCc1ccc(CN2CCC(P(=O)(OCC)OCC)C2)cc1>>CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1,,CC#N,,C[Si](C)(C)Br,,val
US05446153,CC(C)CN.Cc1cc(O)c([N+](=O)[O-])c(=O)[nH]1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(NCC(C)C)c([N+](=O)[O-])c(OS(=O)(=O)C(F)(F)F)n1,,ClCCl,,CCN(CC)CC,,val
US06673804B1,CO.COc1ccc(S(=O)(=O)NC(CCN2C(=O)c3ccccc3C2=O)C(=O)O)cc1>>COC(=O)C(CCN1C(=O)c2ccccc2C1=O)NS(=O)(=O)c1ccc(OC)cc1,,C1CCOC1,CO,C[Si](C)(C)Cl,,val
US20120295934A1,C=C1CC2CN(c3ccc(OC(F)(F)F)cc3)C(=O)C2C1.O=C(OO)c1cccc(Cl)c1>>O=C1C2CC3(CO3)CC2CN1c1ccc(OC(F)(F)F)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US04689327,CNC(=S)N1CCSC1c1ccc(O)cc1.Cc1ccc(S(=O)(=O)OCCCl)cc1>>CNC(=S)N1CCSC1c1ccc(OCCCl)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030232846A1,CC(C)[C@H](NCc1ccccc1N)C(=O)OC(C)(C)C.O=C(n1ccnc1)n1ccnc1>>CC(C)[C@@H](C(=O)OC(C)(C)C)N1Cc2ccccc2NC1=O,,C1CCOC1,,,,val
US20050256158A1,CC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2ccc(OCC3CCCC3C(=O)[O-])cc2)c2ccccc21>>CC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2ccc(OC[C@@H]3CCC[C@H]3C(=O)O)cc2)c2ccccc21,,CO,,O=C([O-])[O-].[K+].[K+],,val
US05378803,CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.CC(C)C[C@H](N)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O>>CC(C)(C)OC(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)O.CC(C)C[C@H](N)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O,,C1CCOC1,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20080207891A1,CCCc1nccn1-c1nc(Cl)nc2nc[nH]c12.Cc1ccc(C(=O)OC[C@H]2O[C@H](Cl)C[C@@H]2OC(=O)c2ccc(C)cc2)cc1>>CCCc1nccn1-c1nc(Cl)nc2c1ncn2[C@H]1C[C@H](OC(=O)c2ccc(C)cc2)[C@@H](COC(=O)c2ccc(C)cc2)O1,,CC#N,ClCCl,[Na],,val
US20050009840A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.Nc1ncc(-c2ccccc2)cc1O>>Oc1cc(-c2ccccc2)cnc1NC(c1ccccc1)(c1ccccc1)c1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20040029963A1,CC(=O)O[C@H](CC(=O)[O-])C[N+](C)(C)C.O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O.[Cl-]>>CC(=O)O[C@H](CC(=O)Oc1c(C(=O)O)cc2ccccc2c1Cc1c(O)c(C(=O)O)cc2ccccc12)C[N+](C)(C)C.[Cl-],,CCOCC,,,,val
US20100120793A1,CCOC(=O)C1(C(=O)O)CCN(C(=O)c2ccc(OC)cc2)C1>>COc1ccc(C(=O)N2CCC(CO)(C(=O)O)C2)cc1,,CC(C)O,,[BH4-].[Li+],,val
US20050187223A1,CC(C)(C)[Si](C)(C)OC1CN(c2ccnc(S(C)(=O)=O)n2)c2nc(-c3ccccc3)cc(=O)n2C1.C[C@H](N)c1ccccc1>>CC(Nc1nccc(N2CC(O[Si](C)(C)C(C)(C)C)Cn3c2nc(-c2ccccc2)cc3=O)n1)c1ccccc1,,C1COCCO1,CCOC(C)=O,,,val
US20080207654A1,CC(=N)N.CCCC(=O)C(Cc1ccc(-c2ccccc2C#N)c(OC)c1)C(=O)OCC>>CCCc1nc(C)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)c(OC)c1,,CO,,Cl,C[O-].[Na+],val
US20030078288A1,COC(=O)CC(=O)Nc1cc(Cl)c(Oc2ccc3[nH]cc(C(C)C)c3c2)c(Cl)c1>>CC(C)c1c[nH]c2ccc(Oc3c(Cl)cc(NC(=O)CC(=O)O)cc3Cl)cc12,,CCO,,[Na+].[OH-],,val
US04065456,O=c1[nH]ccc2c(O)cccc12.OCC1CO1>>O=c1[nH]ccc2c(OCC(O)CO)cccc12,,[Na+],[OH-],,,val
US20160214934A1,BrCCCOc1cccc2ccccc12.COC(=O)Cc1c[nH]c2ccccc12>>COC(=O)Cc1cn(CCCOc2cccc3ccccc23)c2ccccc12,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070275968A1,CC(=O)c1cc(-c2nc(C(C)C)[nH]c2-c2cccc(C)n2)ccc1F.CNN.COC(OC)N(C)C>>Cc1cccc(-c2[nH]c(C(C)C)nc2-c2ccc(F)c(-c3ccnn3C)c2)n1,,CC(=O)O,,,,val
US20080275244A1,Nc1ncccc1-c1cc(Cc2ccc(COc3ccccn3)cc2)no1.O=S(=O)(O)c1ccccc1>>Nc1ncccc1-c1cc(Cc2ccc(COc3ccccn3)cc2)no1.O=S(=O)(O)c1ccccc1,,CO,,,,val
US20140288118A1,Nc1ccc(-c2ccc(NC(=O)[C@H]3CN4CCC3CC4)cc2)cc1.O=S(=O)(Cl)Cc1ccccc1>>O=C(Nc1ccc(-c2ccc(NS(=O)(=O)Cc3ccccc3)cc2)cc1)[C@H]1CN2CCC1CC2,,c1ccncc1,,Cl,Cl,val
US04101659,NC(c1ccccc1)c1ccc(Cl)cc1.S=C=S>>S=C=NC(c1ccccc1)c1ccc(Cl)cc1,,CCOCC,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100168080A1,COc1ccc(NC(=O)OC(C)(C)C)c(OCCCBr)c1>>COc1ccc(N)c(OCCCBr)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160002175A1,NC1CCOCC1.Nc1nc(Cl)cc(Cl)n1>>Nc1nc(Cl)cc(NC2CCOCC2)n1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US05138058,Cc1nccc(N2CCNCC2)n1.O=C(Cl)c1ccccc1>>Cc1nccc(N2CCN(C(=O)c3ccccc3)CC2)n1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04658001,C=Cc1ccccc1.CCC(C)c1ccccc1OC(=O)NC.O=C(OOC(=O)c1ccccc1)c1ccccc1>>C=Cc1ccccc1.O=C([O-])O[O-],,CO,,O=O,,val
US04738972,BrCc1ccccc1.O=C1CCCc2cc(Br)ccc21>>O=C1c2ccc(Br)cc2CCC1Cc1ccccc1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20070149585A1,NC1COc2ccc3c(c2C1)C(=O)NCC3.O=CCCc1c[nH]c2ccc(F)cc12>>O=C1NCCc2ccc3c(c21)CC(NCCCc1c[nH]c2ccc(F)cc12)CO3,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20120058984A1,CCc1ccc([N+](=O)[O-])c(N)n1.Cl>>CCc1ccc([N+](=O)[O-])c(Cl)n1,,O,,O=N[O-].[Na+],,val
US20030186970A1,CC[C@@H]1COc2cc([N+](=O)[O-])ccc2N1CC(F)(F)F>>CC[C@@H]1COc2cc(N)ccc2N1CC(F)(F)F,[Pd],CCOC(C)=O,,,,val
US07238714B2,COc1cccc(-c2nccn2C)c1>>Cn1ccnc1-c1cccc(O)c1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20110046133A1,COC(=O)c1ccc(CBr)c([N+](=O)[O-])c1.O=Cc1c(Cl)cccc1Cl>>COC(=O)c1ccc(/C=C/c2c(Cl)cccc2Cl)c([N+](=O)[O-])c1,,CN(C)C=O,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])[O-].[K+].[K+],val
US20100113462A1,CCOC(=O)C1(N)Cc2ccccc2C1.O=S(=O)(Cl)c1cc(Cl)cc(Cl)c1O>>CCOC(=O)C1(NS(=O)(=O)c2cc(Cl)cc(Cl)c2O)Cc2ccccc2C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20070072853A1,CCNc1ccc2c(c1)nc(C(C)(C)C)n2CC1CCOCC1.O=S(=O)(Cl)c1ccccc1>>CCN(c1ccc2c(c1)nc(C(C)(C)C)n2CC1CCOCC1)S(=O)(=O)c1ccccc1,CN(C)c1ccncc1,CC#N,CCOC(C)=O,Cl,,val
US20160249617A1,BrP(Br)Br.OCc1ccn(-c2ccc(Cl)cc2)n1>>Clc1ccc(-n2ccc(CBr)n2)cc1,,O,,ClC(Cl)Cl,,val
US20140275087A1,COc1ccc([C@@H]2CN(S(=O)(=O)c3cn(C)cn3)C[C@H]2NC(=O)OC(C)(C)C)cc1>>COc1ccc([C@@H]2CN(S(=O)(=O)c3cn(C)cn3)C[C@H]2N)cc1,,C1COCCO1,,Cl,,val
US20030191115A1,COc1ccc(-n2nc(S(C)(=O)=O)c3c2C(=O)N(c2ccc(I)cc2)CC3)cc1.O=C1CN(C(=O)OCc2ccccc2)CCN1>>COc1ccc(-n2nc(S(C)(=O)=O)c3c2C(=O)N(c2ccc(N4CCNCC4=O)cc2)CC3)cc1,[Cu]I,CCOC(C)=O,O,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20100261679A1,CC(C)(C)[Si](C)(C)OCCOc1ccccc1N.CNC(=O)c1cc(Oc2ccc3nc(S(C)(=O)=O)ncc3c2)ccn1>>CNC(=O)c1cc(Oc2ccc3nc(Nc4ccccc4OCCO[Si](C)(C)C(C)(C)C)ncc3c2)ccn1,,CN(C)C=O,,,,val
US20160096834A1,CN(C)c1ccc(C(=O)O)nc1.Nc1nccc(Cl)c1N>>CN(C)c1ccc(-c2nc3c(Cl)ccnc3[nH]2)nc1,,O,,[Na+].[OH-],[Cl-].[NH4+],val
US20070213279A1,N#Cc1cccc(C(=O)O)c1>>NCc1cccc(CO)c1,,C1CCOC1,,B,,val
US20080064740A1,Cc1sc(C(=O)O)c2c1[C@H]1[C@@H](C2)C1(C)C.[Li]C>>CC(=O)c1sc(C)c2c1C[C@@H]1[C@H]2C1(C)C,,CCOCC,,,,val
US20090131378A1,CC(C)(O)C[C@H]1CO[C@](C)([C@H]2CC[C@H]3[C@@H](O)CCC[C@@]32C)C1>>CC(C)(O)C[C@H]1CO[C@](C)([C@H]2CC[C@H]3C(=O)CCC[C@@]32C)C1,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20100292334A1,CC1=CC(=O)c2ccccc2C1=O.COc1ccc(C(=O)NN)cc1>>COc1ccc(C(=O)N/N=C2\C=C(C)C(=O)c3ccccc32)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060211717A1,CC(O)c1ccccc1F.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3cc(C)c(NC(=O)OC(C)c4ccccc4F)cc3C)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US20050085465A1,C=CCN1CCN(CCCOc2cc3ncnc(Cl)c3cc2OC)CC1.Oc1cnc2[nH]ccc2c1>>C=CCN1CCN(CCCOc2cc3ncnc(Oc4cnc5[nH]ccc5c4)c3cc2OC)CC1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20120214767A1,C=Cc1cc2c(cc1C)-c1noc(-c3noc(-c4ccccc4)c3C(F)(F)F)c1CC2.O=[O+][O-]>>Cc1cc2c(cc1C=O)CCc1c-2noc1-c1noc(-c2ccccc2)c1C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20090124629A1,COC(=O)c1ccnnc1.NN>>NNC(=O)c1ccnnc1,,CO,,O,,val
US05223498,CCCCCN(C)C(=O)N(C)C.Nc1ccccc1N1CCOCC1>>CCCCCN(C)C(=Nc1ccccc1N1CCOCC1)N(C)C,,c1ccccc1,,O=P(Cl)(Cl)Cl,,val
US20120115811A1,CS(=O)(=O)Cl.Cc1cc(-c2cc(N)cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)OC(C)(C)C)c2)ccn1>>Cc1cc(-c2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)OC(C)(C)C)cc(NS(C)(=O)=O)c2)ccn1,,ClCCl,O,CCN(CC)CC,O=C([O-])O.[Na+],val
US05804601,CCOC(=O)CCCCC(c1ccc(O)cc1)c1c(C)cc2ccccc2c1OC.CI>>COc1ccc(C(CCCCC(=O)O)c2c(C)cc3ccccc3c2OC)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130225589A1,CCN(CC)S(F)(F)F.CSc1ncc2c(=O)n(-c3c(Cl)cccc3Cl)cc(CO)c2n1>>CSc1ncc2c(=O)n(-c3c(Cl)cccc3Cl)cc(CF)c2n1,,ClCCl,,CCN(CC)CC,,val
US20100022581A1,CC(C)(C)OC(=O)N1CCC[C@@H]1Cc1c[nH]c2cccnc12>>CN1CCC[C@@H]1Cc1c[nH]c2cccnc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120330056A1,CI.O=C(O)c1c(F)cccc1F.[Li]CCCC>>CCCCc1cccc(F)c1C(=O)O,,C1CCOC1,,O,,val
US05663185,COC(=O)C(=O)c1ccc[nH]1.CON>>CON=C(C(=O)OC)c1ccc[nH]1,,CO,,Cl,,val
US20020040043A1,N#Cc1ccc(CCSc2cccc(N)c2)cc1.O=S(=O)(Cl)c1ccccc1>>N#Cc1ccc(CCSc2cccc(NS(=O)(=O)c3ccccc3)c2)cc1,,ClCCl,c1ccncc1,Cl,,val
US20030199440A1,CC(C)(C)OC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1.Cl>>Cl.N=C(N)Nc1ncc(Cl)c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)O)cc12,,CCOC(C)=O,Cl,,,val
US20110136802A1,COC(=O)C1CCN(C(=O)c2cc(O)c3c(c2)S(=O)(=O)C[C@H]2[C@@]3(C)CC[C@H]3C(C)(C)CCC[C@@]32C)CC1>>CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)c3c(O)cc(C(=O)N4CCC(C(=O)O)CC4)cc3S(=O)(=O)C[C@@H]12,,CO,O,[Li]O,,val
US20130345419A1,COc1ccc(OCC(=O)NNC(=O)[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1OC.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COc1ccc(OCc2nnc([C@@H]3CCCN3C(=O)OC(C)(C)C)s2)cc1OC,,Cc1ccccc1,,,,val
US20090275606A1,CCOC(=O)CC(=O)CC(=O)OCC.COC1=NCCC1>>CCOC(=O)c1c(O)cc(=O)n2c1CCC2,,CCN(CC)CC,,,,val
US20140256711A1,CC(C)(C)OC(=O)NC1CCN(CCO)CC1>>NC1CCN(CCO)CC1,,CCO,,Cl,,val
US20020147214A1,Cn1cncc1C=O.OCCO>>Cn1cncc1C1OCCO1,,OCCO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04596816,CCOC(=O)CC(=O)OCC.Cc1nc(-c2cccc(Cl)c2)c(CBr)o1>>Cc1nc(-c2cccc(Cl)c2)c(CCC(=O)O)o1,,CN(C)C=O,O,[H-].[Na+],,val
US20080306125A1,Cc1cc(OCc2c(-c3c(Cl)cccc3Cl)noc2C(C)C)ccc1Br.O=C(O)c1cccc2sc(B(O)O)cc12>>Cc1cc(OCc2c(-c3c(Cl)cccc3Cl)noc2C(C)C)ccc1-c1cc2c(C(=O)O)cccc2s1,,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US04112112,CC(=O)OC(C)=O.Nc1ccc2ccn3cccc3c(=O)c2c1>>CC(=O)Nc1ccc2ccn3cccc3c(=O)c2c1,,c1ccncc1,,,,val
US04322414,COP(=O)(Cl)Sc1cccc([N+](=O)[O-])c1.O=C1CCc2cccc(O)c21>>COP(=O)(Oc1cccc2c1C(=O)CC2)Sc1cccc([N+](=O)[O-])c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20090105231A1,N[C@H](CO)c1ccccc1.O=C([O-])N(c1ccc(-c2ccncc2)cc1)c1ccc([N+](=O)[O-])cc1>>O=C(Nc1ccc(-c2ccncc2)cc1)N[C@H](CO)c1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120309738A1,CNc1cc(N2CCC(C(F)(F)F)CC2)c(Cl)cc1[N+](=O)[O-]>>CNc1cc(N2CCC(C(F)(F)F)CC2)c(Cl)cc1N,[Pt],CO,,C1CCOC1,,val
US20150126490A1,OCc1cc(F)cc(I)c1>>O=Cc1cc(F)cc(I)c1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20150361039A1,CC(C)CNc1ccc(Cl)cc1.Cc1noc(C)c1COc1ccc(S(=O)(=O)Cl)cc1>>Cc1noc(C)c1COc1ccc(S(=O)(=O)N(CC(C)C)c2ccc(Cl)cc2)cc1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20050239766A1,CC(C)(C)OC(=O)CBr.O=C1C(CCSc2ccc(F)cc2)C(c2ccc(O)cc2)N1c1ccc(F)cc1>>CC(C)(C)OC(=O)COc1ccc(C2C(CCSc3ccc(F)cc3)C(=O)N2c2ccc(F)cc2)cc1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030171370A1,CC(=O)OC(C)=O.CCN(CC)C(=O)c1ccc(C(O)c2ccccc2OC)cc1>>CCN(CC)C(=O)c1ccc(C(OC(C)=O)c2ccccc2OC)cc1,,c1ccncc1,,CO,,val
US06004977,COC=Cc1ccc(OCc2ccccc2)c(OC)c1.Cl.NNc1ccncc1>>COc1cc(CC=NNc2ccncc2)ccc1OCc1ccccc1.Cl,Cc1ccc(S(=O)(=O)O)cc1,CCO,,,,val
US20080161252A1,COC(=O)CBr.COc1cc(OC)c(/C=C/S(=O)(=O)Cc2ccc(OC)c(N)c2)c(OC)c1>>COC(=O)CNc1cc(CS(=O)(=O)C=Cc2c(OC)cc(OC)cc2OC)ccc1OC,,CO,,CC(=O)[O-].[Na+],,val
US20130184272A1,CCOC(=O)c1sc(Oc2ccc(F)cc2)c2c1CCc1cnn(C)c1-2>>Cn1ncc2c1-c1c(Oc3ccc(F)cc3)sc(C(=O)O)c1CC2,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20120307177A1,CCCC1CCC(/C(F)=C(\F)I)CC1.CCOc1ccc(B(O)O)c(F)c1F>>CCCC1CCC(/C(F)=C(\F)c2ccc(OCC)c(F)c2F)CC1,,CCO,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],val
US06989393B2,NC1CCN(C(=O)OCc2ccccc2)CC1.O=[N+]([O-])c1ccccc1F>>O=C(OCc1ccccc1)N1CCC(Nc2ccccc2[N+](=O)[O-])CC1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06734200B1,Cc1nccn1-c1ccc(N2C[C@H](CN(C(=O)OC(C)(C)C)c3ccon3)OC2=O)cc1F>>Cc1nccn1-c1ccc(N2C[C@H](CNc3ccon3)OC2=O)cc1F,,ClCCl,,,,val
US20010047099A1,CS(C)=O.Nc1c(Cl)c(Cl)nc(C(=O)O)c1Cl.Oc1ccccc1>>COC(=O)c1nc(Oc2ccccc2)c(Cl)c(N)c1Cl,,O,,[Na+].[OH-],,val
US20130203727A1,C#CC(C)(C)O.CC#N.CCOC(=O)C(=O)c1c(C)cc2ccc(Br)cc2c1-c1ccc(Cl)cc1.CCOC(=O)[C@@H](O)c1c(C)cc2cc(OS(=O)(=O)C(F)(F)F)ccc2c1-c1ccc(Cl)cc1>>Cc1cc2ccc(C#CC(C)(C)O)cc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O,,CC#N,O,[BH4-].[Na+],,val
US20080146636A1,O=C(O)c1ccc(C(F)(F)F)cc1C(=O)O>>OCc1ccc(C(F)(F)F)cc1CO,,C1CCOC1,,B,CO,val
US20150018331A1,COC(=O)c1ccc(/C=C/C#Cc2ccccc2)cc1>>O=C(O)c1ccc(/C=C/C#Cc2ccccc2)cc1,,CS(C)=O,,,,val
US05442060,CCCCCC(C(=O)OCC)C(=O)OCC.COc1cccc(CCl)c1OC>>CCCCCC(Cc1cccc(OC)c1OC)(C(=O)OCC)C(=O)OCC,,CN(C)C=O,,O,[H-].[Na+],val
US04717418,CCC(=O)OC(=O)CC.Cc1c(C)c(C)c(C2CC(=O)C=C(O)C2)c(C)c1C>>CCC(=O)C1=C(O)CC(c2c(C)c(C)c(C)c(C)c2C)CC1=O,,CN(C)C=O,,O,[H-].[Na+],val
US20070142362A1,C=O.O=C(CCC(F)(F)F)Cc1ccccc1>>C=C(C(=O)CCC(F)(F)F)c1ccccc1,,CC(=O)O,,C1CCNCC1,,val
US20110201593A1,CC(C)(C)OC(=O)NC1CCCC(C(=O)O)C1.N>>CC(C)(C)OC(=O)NC1CCCC(C(N)=O)C1,,C1CCOC1,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20110105436A1,C#Cc1cnccc1-c1csc(Nc2cccc(C)c2)n1>>CCc1cnccc1-c1csc(Nc2cccc(C)c2)n1,[Pd],CCO,,,,val
US20120059028A1,CCCI.COC(=O)Cc1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCOC3>>CCCC(C(=O)OC)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCOC3,,CN(C)C=O,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US09169295B2,C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)OC(C)(C)C>>C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)OC(C)(C)C,,CN(C)C=O,,C1CCNCC1,,val
US20020198189A1,CCC=O.N[C@@H](Cc1c[nH]cn1)C(=O)O>>CC[C@@H]1N[C@H](C(=O)O)Cc2nc[nH]c21,,CO,O,Cl,[Na+].[OH-],val
US20060252931A1,COC(=O)[C@@H](Cc1cc(C)c2[nH]c(N(C)C)nc2c1)OC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc2nc(N(C)C)[nH]c12,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20070117836A1,CN(C)CCN1C(=O)c2cccc3cc(N)cc(c23)C1=O.FC(F)(F)Oc1ccc(N=C=S)cc1>>CN(C)CCN1C(=O)c2cccc3cc(NC(=S)Nc4ccc(OC(F)(F)F)cc4)cc(c23)C1=O,,CC#N,,,,val
US20100069391A1,COC(=O)[C@H]1CC[C@@H](N(C)C(=O)OC(C)(C)C)CC1>>CN[C@H]1CC[C@@H](C(=O)OC)CC1,,C1COCCO1,,Cl,,val
US05919789,CCCN=C=O.Cc1ccccc1N>>CCCNC(=O)Nc1ccccc1C,,Cc1ccccc1,,,,val
US20140005226A1,BrCCOc1ccccc1.COC(=O)[C@H]1CCCCN1>>COC(=O)[C@H]1CCCCN1CCOc1ccccc1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US05158949,CCCCN(CCCC)c1ccc(OC)cc1>>CCCCN(CCCC)c1ccc(O)cc1,,Br,,,,val
US20130143863A1,N.O=C(O)COc1cncc(N2CCc3cc(Cl)ccc3C2=O)c1>>NC(=O)COc1cncc(N2CCc3cc(Cl)ccc3C2=O)c1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050009804A1,COC(=O)c1sc(-c2ccccc2)cc1N(C(=O)C1CCC(C)CC1)C1CCNCC1.N#CBr>>COC(=O)c1sc(-c2ccccc2)cc1N(C(=O)C1CCC(C)CC1)C1CCN(C#N)CC1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20110046132A1,CCOC(=O)c1cnn(-c2nc3cc(Oc4ccccc4)c(Cl)cc3[nH]2)c1>>O=C(O)c1cnn(-c2nc3cc(Oc4ccccc4)c(Cl)cc3[nH]2)c1,,CC(=O)O,,Cl,O,val
US20090270380A1,CC(C)N.COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)C[C@@H](COS(=O)(=O)c4ccc(C)cc4)[C@@H]3c3ccc(COCCOC)cc3)cc21>>COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)C[C@@H](CNC(C)C)[C@@H]3c3ccc(COCCOC)cc3)cc21,,CN1CCCC1=O,O,,,val
US20050277662A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC(CC(=O)O)C1CC1>>CC(C)(C)OC(=O)NC(CC(=O)O)C1CC1,,C1CCOC1,,O,[Na+].[OH-],val
US20070072859A1,C1COCCN1.CN(CC[C@@H]1CO1)Cc1ccccc1>>CN(CC[C@@H](O)CN1CCOCC1)Cc1ccccc1,,CO,,,,val
US20070244095A1,CCc1cc2c(cc1C(F)(F)F)N(C(=O)OC(C)(C)C)CCC[C@@H]2NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1.N#CBr>>CCc1cc2c(cc1C(F)(F)F)N(C(=O)OC(C)(C)C)CCC[C@@H]2N(C#N)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20130237502A1,CC(C)(C)OC(=O)N1[C@H](CF)[C@@H](c2ccc(-c3ccn4cc(CNS(C)(=O)=O)nc4c3)cc2)OC1(C)C>>CS(=O)(=O)NCc1cn2ccc(-c3ccc([C@@H](O)[C@H](N)CF)cc3)cc2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04213985,CC(C)=CCN1CCNCC1.O=C1Nc2cccnc2N(C(=O)CCCl)c2ccccc21>>CC(C)=CCN1CCN(CCC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US04062859,CCCCCCCCN1C(=O)C(Cl)C(Cl)S1=O.O=C(OO)c1cccc(Cl)c1>>CCCCCCCCN1C(=O)C(Cl)C(Cl)S1(=O)=O,,ClC(Cl)Cl,,,,val
US20040058820A1,O=C(O)C(Oc1ccc(Cl)cc1)c1ccc(Cl)cc1>>OCC(Oc1ccc(Cl)cc1)c1ccc(Cl)cc1,,C1CCOC1,,B,,val
US20150031689A1,CC(C)(C)OC(=O)N1CCC[C@H](N)C1.Clc1ccc(-n2c(-c3ccccc3Cl)nc3c(Cl)ncnc32)cc1>>CC(C)(C)OC(=O)N1CCC[C@H](Nc2ncnc3c2nc(-c2ccccc2Cl)n3-c2ccc(Cl)cc2)C1,,CCO,,CCN(CC)CC,,val
US20060293337A1,CN.CS(=O)(=O)O[C@@H]1CCCN(c2ccc3c(NC(=O)CC4CCCCC4)c(Cl)ccc3n2)C1>>CNC1CCCN(c2ccc3c(NC(=O)CC4CCCCC4)c(Cl)ccc3n2)C1,,CCO,,,,val
US20090197862A1,CC(C)(C)OC(=O)N1CCC(n2cc(-c3cnc(N)c(N4CCc5c(F)ccc(F)c5C4)c3)cn2)CC1>>Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1N1CCc2c(F)ccc(F)c2C1,,CCOCC,CO,Cl,,val
US20100087418A1,CC(C)(C)OC(=O)N1CCOc2c(cccc2C2=CCCC2)C1>>CC(C)(C)OC(=O)N1CCOc2c(cccc2C2CCCC2)C1,[Pd],CO,,,,val
US05534515,COc1ccc(Cn2c(C)cc3cnnc(Cl)c32)cc1.OCc1ccccc1>>COc1ccc(Cn2c(C)cc3cnnc(OCc4ccccc4)c32)cc1,,CN1CCCC1=O,,CC(C)(C)[O-].[K+],,val
US20060135578A1,COC(=O)c1ccc(-c2nc(CCl)c(C)o2)cc1.COc1cc(C=O)ccc1O>>COC(=O)c1ccc(-c2nc(COc3ccc(C=O)cc3OC)c(C)o2)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20080234314A1,II.OCc1ccc2c(c1)OCO2>>OCc1cc2c(cc1I)OCO2,,ClC(Cl)Cl,,,,val
US20140315888A1,CNC1CN(c2nc3ncc(Br)cc3n3cnnc23)C1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CNC1CN(c2nc3ncc(Br)cc3n3cnnc23)C1.O=C(O)CC(O)(CC(=O)O)C(=O)O,,C1CCOC1,,,,val
US06329400B1,COC(=O)[C@H](CC1CCC(c2ccccc2)CC1)[C@@H](C)O>>C[C@@H](O)[C@@H](CC1CCC(c2ccccc2)CC1)C(=O)O,,C1CCOC1,O,CO,[Li+].[OH-],val
US20130150339A1,COc1cc(F)ccc1B(O)O.COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(Cl)ncc(O)c3c2)c(OC)c1>>COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(-c4ccc(F)cc4OC)ncc(O)c3c2)c(OC)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US05591860,CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)O)C(C)C)co1.N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1ccno1>>CC(C)[C@H](NC(=O)N(C)CC1=CON(C(C)C)C1)C(=O)N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1ccno1,,ClCCl,,CO,,val
US20090042925A1,CC(C)(C)OC(=O)NCCn1c(CON2C(=O)c3ccccc3C2=O)nc2c(N)nc3cc(OCc4ccccc4)ccc3c21>>CC(C)(C)OC(=O)NCCn1c(CON)nc2c(N)nc3cc(OCc4ccccc4)ccc3c21,,CCO,,NN,O,val
US20110275624A1,BrCCBr.Oc1cc(Br)ccc1NC1CCOCC1>>Brc1ccc2c(c1)OCCN2C1CCOCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100137588A1,CC(=O)OC(C)=O.CN(C)[c-]1cccc1CO.[Fe+2].c1cc[cH-]c1>>CC(=O)OCc1ccc[c-]1N(C)C.[Fe+2].c1cc[cH-]c1,CN(C)c1ccncc1,C1CCOC1,CCOCC,CCN(CC)CC,,val
US05696276,CC(C)=CC[C@@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O.CCCCC(=O)O>>CCCCC(=O)OC(CC=C(C)C)C1=CC(=O)c2c(O)ccc(O)c2C1=O,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20140315801A1,CC(C)(C)OC(=O)N1CC(N)C1.O=Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1>>CC(C)(C)OC(=O)N1CC(NCc2ccc(-c3cc4nccc(Oc5ccc(NC(=O)NC6CC6)cc5F)c4s3)nc2)C1,,CN1CCCC1=O,,CC(=O)O,O=C([O-])O.[Na+],val
US20160024053A1,CC(=O)c1cn(-c2ncc(-c3ccccc3F)cn2)c2cc(C(=O)N3CCOCC3)ccc12.C[Mg]I>>CC(C)(O)c1cn(-c2ncc(-c3ccccc3F)cn2)c2cc(C(=O)N3CCOCC3)ccc12,,C1CCOC1,,,,val
US20100069394A1,CC(C)(C)OC(=O)N1CCNCC1.Clc1cc(-c2ccccc2)c(Cl)nn1>>CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccccc3)c(Cl)nn2)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US05360802,Nc1nncs1.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1>>O=[N+]([O-])c1cccc(S(=O)(=O)Nc2nncs2)c1,,c1ccncc1,,[Na+].[OH-],,val
US20090240052A1,CC(C)(C)OC(=O)c1ccc(Br)cc1NC(=O)c1ccccc1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(C)(C)OC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1NC(=O)c1ccccc1,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20120178934A1,CC#CCBr.COC(=O)c1ccc(O)cc1>>CC#CCOc1ccc(C(=O)OC)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05534529,Br[Mg]CC1CCCCC1.CC(C)(C)c1ccc(CCC=O)cc1NC(=O)CC1c2ccccc2Oc2ccccc21>>CC(C)(C)c1ccc(CCC(O)CC2CCCCC2)cc1NC(=O)CC1c2ccccc2Oc2ccccc21,,CCOCC,,C1CCOC1,[Cl-].[NH4+],val
US20150315172A1,COC(=O)CCn1cc(C(=O)N2CCC(c3ccc(F)cc3)CC2)c(Nc2cc(C)ccc2Cl)cc1=O>>Cc1ccc(Cl)c(Nc2cc(=O)n(CCC(=O)O)cc2C(=O)N2CCC(c3ccc(F)cc3)CC2)c1,,CO,,[Na+].[OH-],,val
US20130210801A1,C[Si](C)(C)CCOC(=O)NCCBr.Cc1cc2[nH]c(=O)ccc2c(-c2ccc(Cl)cc2)c1[C@@H](CO[Si](C)(C)C(C)(C)C)OC(C)(C)C>>Cc1cc2c(ccc(=O)n2CCNC(=O)OCC[Si](C)(C)C)c(-c2ccc(Cl)cc2)c1[C@@H](CO[Si](C)(C)C(C)(C)C)OC(C)(C)C,,CCOC(C)=O,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US04607128,C=CCO.FC(F)(F)c1ccc(Cl)cc1>>CC=COc1ccc(C(F)(F)F)cc1,,O=S1(=O)CCCC1,,[K+].[OH-],,val
US20050222142A1,CNC(=O)C(O)C(c1ccccc1)N1CCOc2ccccc21>>CNCC(O)C(c1ccccc1)N1CCOc2ccccc21,,C1CCOC1,,B,Cl,val
US20150368210A1,CC(C)(C)OC(=O)[C@H]1CC(NCc2ccc(-c3cnc(N)c(NCc4c(Cl)cccc4Cl)n3)cc2)CCN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)[C@H]1CC(NCc2ccc(-c3cnc(N)c(NCc4c(Cl)cccc4Cl)n3)cc2)CCN1,,C1COCCO1,,Cl,[Na+].[OH-],val
US20160122364A1,Brc1cnc2c(N3CCOCC3)snc2c1.COc1ccc(B(O)O)c(OC)c1>>COc1ccc(-c2cnc3c(N4CCOCC4)snc3c2)c(OC)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20100197926A1,CCN(CC)C(=O)Cl.COc1cccc(O)c1C>>CCN(CC)C(=O)Oc1cccc(OC)c1C,,CC#N,O,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20090082464A1,CC(=O)NCCCS(=O)(=O)Cl.CC(C)C(=O)OCCOC(=O)NCC(C)(C)CO>>CC(=O)NCCCS(=O)(=O)OCC(C)(C)CNC(=O)OCCOC(=O)C(C)C,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20090318436A1,CC(C)(C)OC(=O)N1CCC(O)(c2cnc3c(NCc4nnc5ccc(-c6cc(F)cc(F)c6)nn45)ccnc3c2)CC1.CCN(CC)S(F)(F)F>>Fc1cc(F)cc(-c2ccc3nnc(CNc4ccnc5cc(C6(F)CCNCC6)cnc45)n3n2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110124618A1,CCOC(=O)c1cc(-c2cccc(Cl)c2)n(-c2cccc(C(F)(F)F)c2)n1>>O=C(O)c1cc(-c2cccc(Cl)c2)n(-c2cccc(C(F)(F)F)c2)n1,,C1COCCO1,O,[Li+].[OH-],,val
US05929097,COC(=O)c1cc(C)cc(Br)c1NS(=O)(=O)c1ccc(OC)cc1.N#C[Cu]>>COc1ccc(S(=O)(=O)Nc2c(C#N)cc(C)cc2C(=O)O)cc1,,c1ccncc1,,Cl,O,val
US20160229865A1,CC(C)(C)OC(=O)N1CC(CN)C1.Clc1nc(Cl)c2ccsc2n1>>CC(C)(C)OC(=O)N1CC(CNc2nc(Cl)nc3sccc23)C1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20030013715A1,Nc1ccc2ncccc2c1.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>O=C(Nc1ccc2ncccc2c1)C12CC3CC(CC(C3)C1)C2,,O,,c1ccncc1,,val
US20140336166A1,BrBr.C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc[nH]c2n1>>C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc(Br)[nH]c2n1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20070072914A1,CC(C)(C)C(=O)Nc1cccc(C=O)n1.CO>>CC(O)c1cccc(NC(=O)C(C)(C)C)n1,,CCOC(C)=O,,[BH4-].[Na+],,val
US20120184508A1,CC(C)(C)OC(=O)N1CCC(CNc2ncc3c(-c4ccnc(NCc5cccc(Cl)c5)n4)n[nH]c3n2)CC1>>Clc1cccc(CNc2nccc(-c3n[nH]c4nc(NCC5CCNCC5)ncc34)n2)c1,,CCO,,Cl,,val
US20030105151A1,CNS(=O)(=O)c1ccc2c(c1)CC(=O)N2.Cc1c(CCC(=O)O)c[nH]c1C=O>>CNS(=O)(=O)c1ccc2c(c1)C(=Cc1[nH]cc(CCC(=O)O)c1C)C(=O)N2,,CCO,,C1CCNCC1,,val
US20070225267A1,C=COCC(C)(C)C.CC(C)(C)OC(=O)N[C@H](CO)COCc1ccccc1.O=C1CCC(=O)N1I>>CC(C)(C)COC(OCCI)[C@H](COCc1ccccc1)NC(=O)OC(C)(C)C,,CC#N,,CCOC(C)=O,,val
US05175290,CCCn1c(N)c(N=O)c(=O)n(CC(=O)OCC)c1=O>>CCCn1c(N)c(N)c(=O)n(CC(=O)OCC)c1=O,[Pd],CCO,,[H][H],,val
US20040082607A1,CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)C)c(=O)c2ccc(C(=O)O)cc12.OCc1cccc2c1Cc1ccccc1-2.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)C)c(=O)c2ccc(NC(=O)OCC3c4ccccc4-c4ccccc43)cc12,,O,,CCN(CC)CC,CN(C)C=O,val
US20030158185A1,CC(C)(C)OC(=O)NCC[C@@H](Oc1cc(Cl)c(F)cc1C#N)c1ccoc1.O=C(O)/C=C/C(=O)O>>N#Cc1cc(F)c(Cl)cc1O[C@H](CCN)c1ccoc1.O=C(O)/C=C/C(=O)O,,C1COCCO1,Cl,O=C([O-])O.[Na+],,val
US20110053959A1,COC(=O)C1=C(N)CCC1C(C)C.NC=O>>CC(C)C1CCc2ncnc(O)c21,,O,,O=C[O-].[NH4+],,val
US20100222352A1,Brc1nccs1.N#Cc1ccc(N)cc1O>>N#Cc1ccc(Nc2nccs2)cc1O,,CCO,,Cl,,val
US20020042431A1,CI.O=C(NC1CCC(OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1c1ccccc1)OCc1ccccc1>>CN(C(=O)OCc1ccccc1)C1CCC(OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20130252934A1,Cc1nn(C)cc1Nc1nccc(-c2ccn([C@H](CO[Si](C)(C)C(C)(C)C)c3ccc(Cl)c(F)c3)c(=O)c2)n1>>Cc1nn(C)cc1Nc1nccc(-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20020099215A1,CC(C)(C)OC(=O)N1CCC(C(=O)NC(CCCc2cccnc2)CCCc2cccnc2)CC1>>O=C(NC(CCCc1cccnc1)CCCc1cccnc1)C1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080194603A1,O=[N+]([O-])c1ccc(CNS(=O)(=O)C2CC2)cc1>>Nc1ccc(CNS(=O)(=O)C2CC2)cc1,[Pd],CO,,,,val
US20110183985A1,COC(=O)c1nc(Cl)c2ccccc2c1O.C[Sn](C)(C)C>>COC(=O)c1nc(C)c2ccccc2c1O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US20130102009A1,Nc1ccccc1-c1nc2cc(CN3CC[C@@H](F)C3)cnc2s1.O=C(Cl)c1cccc(OC2CN3CCC2CC3)c1>>O=C(Nc1ccccc1-c1nc2cc(CN3CC[C@@H](F)C3)cnc2s1)c1cccc(OC2CN3CCC2CC3)c1,,CO,ClCCl,CCN(CC)CC,,val
US20100076014A1,CC(C)c1cc2[nH]ncc2cc1O.Fc1ccc(I)cc1>>CC(C)c1cc2c(cnn2-c2ccc(F)cc2)cc1O,[Cu]I,C1COCCO1,CCOC(C)=O,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20120071467A1,CC(C)(C)[Si](C)(C)OCC[C@](O)(CO)c1ccc(F)c(Br)c1.CS(=O)(=O)Cl>>CC(C)(C)[Si](C)(C)OCC[C@](O)(COS(C)(=O)=O)c1ccc(F)c(Br)c1,,CCOC(C)=O,ClCCl,CCN(CC)CC,O,val
US20150353488A1,CCOC(=O)C1CCNCC1.C[C@@H]1CCCN1CCc1ccc(-c2ccc(CCC(=O)O)cc2)cc1>>CCOC(=O)C1CCN(C(=O)CCc2ccc(-c3ccc(CCN4CCC[C@H]4C)cc3)cc2)CC1,,CN(C)C=O,,Cl,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120121806A1,CCC(C)(C)c1nc(C(C)(C)C)[nH]c1C(C)(C)CC.Cl[Ti](Cl)(Cl)Cl>>CCC(C)(C)c1nc(C(C)(C)C)[n-]c1C(C)(C)CC.[Cl-].[Cl-].[Cl-].[Ti+4],,Cc1ccccc1,,,,val
US20060229312A1,Cc1ccc2c(N3CCN(CCc4cccc([N+](=O)[O-])c4)CC3)cc(F)cc2n1>>Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cc(F)cc2n1,[Fe],CO,O,[Cl-].[NH4+],,val
US20160264575A1,CC(C)(C)OC(=O)N1Cc2c(c3ccccc3n2Cc2ccc(F)cc2)C[C@H]1C(=O)O.Cl>>Cl.O=C(O)[C@@H]1Cc2c(n(Cc3ccc(F)cc3)c3ccccc23)CN1,,C1COCCO1,,CCN(CC)CC,,val
US04024266,CC1C(=O)c2sccc2C(=C2CCN(C)CC2)c2ccccc21.[Li]C>>CC1c2ccccc2C(=C2CCN(C)CC2)c2ccsc2C1(C)O,,CCOCC,c1ccccc1,[Cl-].[NH4+],,val
US20130012491A1,CCOC(=O)CCCc1cc(F)cc(-c2cnc(-c3ccc(OC(C)C)c(C#N)c3)nc2)c1OC>>COc1c(CCCC(=O)O)cc(F)cc1-c1cnc(-c2ccc(OC(C)C)c(C#N)c2)nc1,,CC(C)O,O,[Na+].[OH-],,val
US20140343151A1,CC1(C)CC(=O)OC1=O.CCCc1c(N)cccc1OCCCOc1cc(OCc2ccccc2)c(-c2ccc(F)cc2)cc1CC>>CCCc1c(NC(=O)CC(C)(C)C(=O)O)cccc1OCCCOc1cc(OCc2ccccc2)c(-c2ccc(F)cc2)cc1CC,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20100197674A1,O=[N+]([O-])c1ccccc1Nc1ccc2c(c1)OCO2>>Nc1ccccc1Nc1ccc2c(c1)OCO2,[Fe],CC(=O)O,,CCOC(C)=O,O,val
US20110070317A1,CC(C)C(=O)Nc1c[nH]c2ncc(Cl)c(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)c12.ClCCl>>CC(C)C(=O)Nc1c[nH]c2ncc(Cl)c(N3CCC[C@@H](N)C3)c12.Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100004312A1,CC(=O)OCc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(CO)c1.COC(=O)C[C@@H]1COc2cc(O)ccc21>>COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)cc(OCCCS(C)(=O)=O)cc4COC(C)=O)c3)ccc21,,CCCCCC,Cc1ccccc1,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US04816452,CCOC(=O)/C(=N\OCc1c(Cl)cccc1Cl)C(=O)CBr.NC(N)=S>>CCOC(=O)/C(=N\OCc1c(Cl)cccc1Cl)c1csc(N)n1,,CCO,,CN(C)c1ccccc1,,val
US06340687B1,C=CCNCCCNc1ccc(Cl)cc1C.S=C(Cl)Cl>>C=CCN1CCCN(c2ccc(Cl)cc2C)C1=S,,ClC(Cl)Cl,ClCCl,CCN(CC)CC,,val
US20150111871A1,C=C(CNC(=O)OC(C)(C)C)c1cccc2c(C(=O)NC)ncnc12.O=C([O-])C(F)(F)F>>C=C(CN)c1cccc2c(C(=O)NC)ncnc12.O=C([O-])C(F)(F)F,,ClCCl,,O=C(O)C(F)(F)F,,val
US05137564,COS(=O)(=O)OC.COc1cc(OC)nc(C(C#N)c2cccc(Cl)c2)n1>>COc1cc(OC)nc(C(C)(C#N)c2cccc(Cl)c2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20120016092A1,CC(=O)c1ccc2cccc(Br)c2n1.CC(C)c1cccc(C(C)C)c1N>>C/C(=N\c1c(C(C)C)cccc1C(C)C)c1ccc2cccc(Br)c2n1,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150065468A1,CC1(C)OB(c2ccc(CC(=O)O)c(F)c2)OC1(C)C.Nc1cc(C2(C(F)(F)F)CC2)on1>>CC1(C)OB(c2ccc(CC(=O)Nc3cc(C4(C(F)(F)F)CC4)on3)c(F)c2)OC1(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120077828A1,Cn1cccc1CC(=O)O.Cn1nc(-c2ccc3c(c2)CCN3)c2c(N)ncnc21>>Cn1cccc1CC(=O)N1CCc2cc(-c3nn(C)c4ncnc(N)c34)ccc21,,O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060014739A1,CCO.O=C(O)c1ccc(F)c2ccccc12>>CCOC(=O)c1ccc(F)c2ccccc12,,CCOC(C)=O,,O=S(=O)(O)O,,val
US06521643B1,CCSC(=N)Nc1nc(C)c(-c2cc(C)ccn2)s1.NO>>Cc1ccnc(-c2sc(NC(=N)NO)nc2C)c1,,CC(C)O,CCOC(C)=O,Cl,CC(=O)[O-].[Na+],val
US20100087431A1,CC(C)(NC=O)c1ccc(F)cc1-c1cccc2cc(-c3nc(NCCn4ccnn4)ncc3F)sc12>>CC(C)(N)c1ccc(F)cc1-c1cccc2cc(-c3nc(NCCn4ccnn4)ncc3F)sc12,,CCO,,[Na+].[OH-],,val
US20030236429A1,CCCCCC(C)=C(NC=O)C(=O)OCC.SCc1ccccc1>>CCCCCC(C)(SCc1ccccc1)C(NC=O)C(=O)OCC,,C1CCOC1,,[Li]CCCC,,val
US20100190782A1,Nc1c(C(=O)O)cnn1-c1ccc(Br)cc1.c1ncncn1>>Brc1ccc(-n2ncc3cncnc32)cc1,,CCOC(C)=O,CS(C)=O,CCOCC,FB(F)F,val
US20080255153A1,CCOC(=O)c1c[nH]nc1N.O=CC(Br)C=O>>CCOC(=O)c1cnn2cc(Br)cnc12,,CCO,ClCCl,CC(=O)O,[Na+].[OH-],val
US20090163462A1,CCOC(=O)CCCN1CCC[C@H]1COc1ccc(Oc2ccc(C)cc2)cc1.Cl>>Cc1ccc(Oc2ccc(OC[C@@H]3CCCN3CCCC(=O)O)cc2)cc1.Cl,,C1COCCO1,,,,val
US20120232051A1,COc1cccc(F)c1-c1ccncc1N(CC(F)(F)F)C(=O)c1cc(C(F)(F)F)cc(S(C)(=O)=O)c1.CS(=O)(=O)CCNc1cnccc1-c1ccccc1OC(F)(F)F>>CS(=O)(=O)CCN(C(=O)c1cc(C(F)(F)F)cc(S(C)(=O)=O)c1)c1cnccc1-c1ccccc1OC(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04044141,CC1=C(C(=O)OCc2ccccc2)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC(C)C)=C(C)N1>>C/C(N)=C/C(=O)OCc1ccccc1,,CC(C)O,,CCO,,val
US20040152699A1,CCOC(=N)c1cccs1.NNC(=O)CCc1nc(-c2cccc(Cl)c2)no1>>CCOC(=NNC(=O)CCc1nc(-c2cccc(Cl)c2)no1)c1cccs1,,CCO,,,,val
US20070225365A1,COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN.O=Cc1cc([N+](=O)[O-])cc(C(F)(F)F)c1>>COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CNCc1cc([N+](=O)[O-])cc(C(F)(F)F)c1,CC(=O)O,CO,,O,[BH3-]C#N.[Na+],val
US04127720,CCOC(=O)C(=CNc1ncc(OC)c2ccccc12)C(=O)OCC>>CCOC(=O)c1cnc2c3ccccc3c(OC)cn2c1=O,,CCCCCC,,c1ccc(Oc2ccccc2)cc1,,val
US20130274258A1,CCCc1nccc2c1[nH]c1ccc(Br)cc12.OB(O)c1ccc2c(c1)CCO2>>CCCc1nccc2c1[nH]c1ccc(-c3ccc4c(c3)CCO4)cc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20060264415A1,COc1ccc(S(=O)(=O)n2ccc(CCCCCN=[N+]=[N-])c2)cc1OC>>COc1ccc(S(=O)(=O)n2ccc(CCCCCN)c2)cc1OC,[Pd],CCOC(C)=O,CO,,,val
US20040039007A1,CC(C)(C)c1cc(Cl)nc(-c2ccccc2C(F)(F)F)n1.Nc1n[nH]c2ncccc12>>CC(C)(C)c1cc(Nc2n[nH]c3ncccc23)nc(-c2ccccc2C(F)(F)F)n1,,CN1CCCC1=O,,O,O=C([O-])O.[Na+],val
US20120238549A1,COC(=O)c1ccc2c(c1)CCC[C@@H]1CC(=O)CC[C@]21CC(F)(F)F.COC(=O)c1ccc2c(c1)CCC[C@H]1CC(=O)CC[C@@]21CC(F)(F)F>>O=C1CC[C@@]2(CC(F)(F)F)c3ccc(C(=O)O)cc3CCC[C@H]2C1.O=C1CC[C@]2(CC(F)(F)F)c3ccc(C(=O)O)cc3CCC[C@@H]2C1,,CO,O,[Li+].[OH-],,val
US20080300242A1,CCOc1cc(N2CCN(C3CCN(CCS(C)(=O)=O)CC3)CC2)ccc1[N+](=O)[O-]>>CCOc1cc(N2CCN(C3CCN(CCS(C)(=O)=O)CC3)CC2)ccc1N,[Pt],CCOC(C)=O,CO,,,val
US04855292,CC1CN(Cc2ccccc2)CC1NC(=O)OC(C)(C)C>>CC1CNCC1NC(=O)OC(C)(C)C,[Pd],CCO,,,,val
US20070275968A1,CC(C)(C)OC(=O)n1ccc(Br)c1.Cc1cccc(-c2nn(S(=O)(=O)N(C)C)cc2-c2ccc(F)c(B3OC(C)(C)C(C)(C)O3)c2)n1>>Cc1cccc(-c2nn(S(=O)(=O)N(C)C)cc2-c2ccc(F)c(-c3ccn(C(=O)OC(C)(C)C)c3)c2)n1,,COCCOC,,O,,val
US06723716B1,O=S(Cl)Cl.OCc1ncccc1SC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cl.ClCc1ncccc1SC(c1ccccc1)(c1ccccc1)c1ccccc1,,CN(C)C=O,,,,val
US20150218093A1,COc1cc(N2CCC(Oc3ccc(OC(F)(F)F)cc3)([Se]c3ccccc3)C2=O)ccc1OCC(C)(C)OCOCC[Si](C)(C)C>>COc1cc(N2CC=C(Oc3ccc(OC(F)(F)F)cc3)C2=O)ccc1OCC(C)(C)OCOCC[Si](C)(C)C,,ClCCl,O,OO,,val
US20100173935A1,CC(C)(C)OC(=O)N1CCC(N2CCC(n3c(=O)n(C(=O)OCc4ccccc4)c4ccccc43)CC2)C1.Cl>>Cl.O=C(OCc1ccccc1)n1c(=O)n(C2CCN(C3CCNC3)CC2)c2ccccc21,,CO,,,,val
US06251904B1,CC(Cl)(Cl)Cl.CCc1ccccn1.O=C1CCC(=O)N1Br>>CC(Br)c1ccccn1.Cl,O=C(OOC(=O)c1ccccc1)c1ccccc1,,,,,val
US20130035446A1,O=C(/C=C/c1ccc(C(F)(F)Oc2ccc(OCCCC(F)(F)F)cc2)cc1)OCCc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>Nc1ccc(CCOC(=O)/C=C/c2ccc(C(F)(F)Oc3ccc(OCCCC(F)(F)F)cc3)cc2)c(N)c1,[Zn],CN(C)C=O,O,,,val
US20140206681A1,COc1ccc(CNc2nccn3c([C@H]4CN(C(=O)OC(C)(C)C)[C@@H](CO[Si](c5ccccc5)(c5ccccc5)C(C)(C)C)CO4)nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c23)c(OC)c1>>Nc1nccn2c([C@H]3CN[C@@H](CO)CO3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12,,O,O=C(O)C(F)(F)F,,,val
US20150299178A1,C1NC[C@@H]2C[C@H]12.COC(=O)C(F)(F)c1nc(Br)cs1>>O=C(N1CC2CC2C1)C(F)(F)c1nc(Br)cs1,,ClCCl,,CCN(CC)CC,Cl,val
US20160031786A1,C=C(C)C=O.CC(C)(C)O>>C=C(C)C.C=C(C)C=O,,CC(C)(C)O,,,,val
US20040229876A1,COc1cc2nccc(Oc3ccc(N)c(F)c3)c2cc1OC.ClC(Cl)Cl.Nc1nccs1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4nccs4)c(F)c3)c2cc1OC.Cl,,ClC(Cl)Cl,O,CCN(CC)CC,,val
US20080207611A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.Nc1ccccn1>>CC(C)(C)OC(=O)N1CCC(Nc2ccccn2)CC1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130267571A1,CC(C)=CCC/C(C)=C/CO.COS(=O)(=O)OC>>COC/C=C(\C)CCC=C(C)C,,CN1CCCC1=O,,[H-].[Na+],,val
US20030158177A1,CC(=O)N1CCc2cc(C(=O)CCN(C)C)ccc21>>CC(=O)N1CCc2cc(C(O)CCN(C)C)ccc21,,CO,,O,[BH4-].[Na+],val
US05877193,NC(N)=S.O=C(CBr)c1ccccc1OCc1ccccc1>>Br.Nc1nc(-c2ccccc2OCc2ccccc2)cs1,,CO,,,,val
US20030199494A1,O=CCCN(Cc1ccccc1)C(=O)C(F)(F)F.OC1CNCc2ccccc2C1(O)C1CCC1>>O=C(N(CCCN1Cc2ccccc2C(O)(C2CCC2)C(O)C1)Cc1ccccc1)C(F)(F)F,,CO,,Cl,[BH3-]C#N.[Na+],val
US20130171127A1,CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1.CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCNC(=O)CCCN)OC(=O)CCCCCCC/C=C\CCCCCCCC>>CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCNC(=O)CCCNC(=O)/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC,,CN(C)C=O,ClC(Cl)Cl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150152096A1,CCOC(=O)C1=C(CBr)NC(c2nccs2)=NC1c1ccccc1C(F)(F)F.O=C(O)C1COCCN1>>CCOC(=O)C1=C(CN2CCOCC2C(=O)O)NC(c2nccs2)=NC1c1ccccc1C(F)(F)F,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2ccc(N)c3c2C(=O)NC3=O)cc2ccccc21>>Nc1ccc(-c2cc3ccccc3[nH]2)c2c1C(=O)NC2=O,,CO,,Cl,O=C([O-])O.[Na+],val
US03976644,Clc1nc(Cl)c(Cl)nc1Cl.NN>>NNc1nc(Cl)c(Cl)nc1Cl,,C1COCCO1,CCO,O,,val
US20100222270A1,CN(C1CCc2c(CC(=O)O)c3cnc(Cl)cc3n2C1)S(=O)(=O)c1ccc(F)cc1>>CN(C1CCc2c(CC(=O)O)c3cccnc3n2C1)S(=O)(=O)c1ccc(F)cc1,[Pd],CO,,,,val
US20020049214A1,CN(C)C=O.Fc1cc(Br)cc(Br)c1>>O=Cc1c(F)cc(Br)cc1Br,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US08754100B2,COc1ccc(C(C)(O)C(F)(F)F)cc1C.ClCCl>>COc1ccc(C(C)(C)C(F)(F)F)cc1C,Cl[Ti](Cl)(Cl)Cl,,,,,val
US20160176896A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1[nH]ncc1[N+](=O)[O-]>>COc1nn(C(=O)OC(C)(C)C)cc1[N+](=O)[O-],CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20070032518A1,O=c1[nH]c2cc(CO)ccc2cc1-c1csc(CS(=O)(=O)c2ccccc2)n1>>O=Cc1ccc2cc(-c3csc(CS(=O)(=O)c4ccccc4)n3)c(=O)[nH]c2c1,O=[Mn]=O,CN(C)C=O,,,,val
US06770596B1,CC(C)(Br)C(=O)Br.Cn1nc(-c2c(F)cc3c(c2N)NC(=O)CO3)c(Cl)c1C(F)(F)F>>Cn1nc(-c2c(F)cc3c(c2NC(=O)C(C)(C)Br)NC(=O)CO3)c(Cl)c1C(F)(F)F,,C1COCCO1,,,,val
US06127354,CN(CCc1ccccc1[N+](=O)[O-])C(=O)OC(C)(C)C>>CN(CCc1ccccc1N)C(=O)OC(C)(C)C,[Pd],CCO,,,,val
US20090036492A1,COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.COc1cccc(C=O)c1>>COc1ccccc1CNC(=O)c1c(OC)cc(O)c2c1OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,,Cc1ccccc1,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20090131433A1,C1CCNC1.O=Cc1cc(Cl)c(O)cc1Cl>>Oc1cc(Cl)c(CN2CCCC2)cc1Cl,,ClCCl,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20070054935A1,Clc1ccc([Mg]Br)cc1Cl.N#Cc1cccc(-c2ccncc2C=O)c1>>N#Cc1cccc(-c2ccncc2C(O)c2ccc(Cl)c(Cl)c2)c1,,C1CCOC1,,,,val
US20130116262A1,CC(=O)Cl.O=C1c2cc3c(n2CCN1c1nccc(Cl)c1CO)CCCC3>>CC(=O)OCc1c(Cl)ccnc1N1CCn2c(cc3c2CCCC3)C1=O,,ClCCl,,CCN(CC)CC,,val
US20030120105A1,N[C@@H]1C[C@H]1c1ccc(F)c(F)c1.O=C(O)[C@H](O)c1ccccc1>>O=C([O-])C(O)c1ccccc1.[NH3+][C@@H]1C[C@@H]1c1ccc(F)c(F)c1,,CCOC(C)=O,,,,val
US05693811,CC(C)(O)Cn1cnc2c(N)nc3ccccc3c21>>CC(C)(O)Cn1cnc2c(N)nc3c(c21)CCCC3,O=[Pt]=O,O=C(O)C(F)(F)F,,,,val
US20050032873A1,CC(C)C=O.NC(=O)c1cccc2c1CC(NCCCc1c[nH]c3ccc(F)cc13)CO2>>CC(C)CN(CCCc1c[nH]c2ccc(F)cc12)C1COc2cccc(C(N)=O)c2C1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20070248672A1,CC(=O)O.COc1ccc(-c2c(C(=O)NN)[nH]c3cc(OC)c(OC)cc23)cc1>>COc1ccc(-c2c(C(=O)NNC(C)=O)[nH]c3cc(OC)c(OC)cc23)cc1,,ClCCl,,,,val
US20090156642A1,CCOC(=O)C#CC(=O)OCC.NNc1cccnc1Cl>>CCOC(=O)c1cc(O)n(-c2cccnc2Cl)n1,,CCO,,Cl,Cl,val
US03963573,CC(=O)O.CO.COC(=O)C(CCSC)NC(C)=O.CSCCC(NC(C)=O)C(=O)O.[Na+].[OH-]>>CC(=O)OC(C)=O.COC(C)=O.[Na+].[OH-],,CC(=O)O,CO,O=S(=O)(O)O,,val
US20080114006A1,C#Cc1cc(F)c([N+](=O)[O-])cc1CC(=O)OCC>>CCOC(=O)Cc1cc(N)c(F)cc1CC,[Pd],CO,,CCOC(C)=O,,val
US06498172B1,CC(C)(C)OC(=O)COc1cccc(CN)c1.CC(C)(C)c1ccc(C=O)cc1>>CC(C)(C)OC(=O)COc1cccc(CNCc2ccc(C(C)(C)C)cc2)c1,,CO,O,[BH4-].[Na+],,val
US20110065708A1,OCc1cnc2ccc(Cl)nn12>>O=Cc1cnc2ccc(Cl)nn12,O=[Mn]=O,ClCCl,,,,val
US20120083488A1,CC1(C)c2cc(OC3CCN(C(=O)C(F)(F)F)CC3)ccc2C(=O)c2c1[nH]c1cc(Br)ccc21>>CC1(C)c2cc(OC3CCNCC3)ccc2C(=O)c2c1[nH]c1cc(Br)ccc21,,C1CCOC1,CO,O,[K+].[OH-],val
US05294631,NCc1ccccc1Cl.O=C(O)c1c(Cl)c(Cl)cc([N+](=O)[O-])c1Cl>>Nc1c([N+](=O)[O-])cc(Cl)c(Cl)c1C(=O)O,,Cc1ccccc1,,Cl,,val
US20100152193A1,CN(C)/C=C/C(=O)c1nn(-c2ccc(OC(F)(F)F)cc2)ccc1=O.N#Cc1cccc(NN)c1>>N#Cc1cccc(-n2nccc2-c2nn(-c3ccc(OC(F)(F)F)cc3)ccc2=O)c1,,CCO,,,,val
US20020193367A1,CC(C)CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3nncc3COC3CCCCO3)c2)cc1C(F)(F)F>>CC(C)CN(C)c1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-n3nncc3CO)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090221551A1,CC(C)(C)OC(=O)N1CCn2c1nc1c(N)nc3cccnc3c12>>Nc1nc2cccnc2c2c1nc1n2CCN1,,C1COCCO1,CO,Cl,,val
US05349107,CCCCC(=O)CCC(C)=O>>CCCCC(=O)CCC(C)O,,ClCCl,,CCN(CC)CC,CO,val
US06071928,CCCC[Sn](CCCC)(CCCC)C(=CC1(O)CCCN(Cc2ccccc2)C1)CO>>CCCC[Sn](CCCC)(CCCC)C1=CC2(CCCN(Cc3ccccc3)C2)OC1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110112151A1,Cc1cc(C)c(C(=O)CBr)c(C)c1.Oc1cccnc1>>Cc1cc(C)c(C(=O)COc2cccnc2)c(C)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05661108,C#CCn1c(C(F)(F)F)nc2cc(F)c([N+](=O)[O-])cc21>>C#CCn1c(C(F)(F)F)nc2cc(F)c(N)cc21,[Fe],CC(=O)O,,CCOC(C)=O,O,val
US20090030176A1,Cc1ccc(-c2nc3cccc(Nc4ccc([N+](=O)[O-])cc4)c3nc2-c2ccc(C)cc2)cc1>>Cc1ccc(-c2nc3ccc(N)c(-c4ccc(N)cc4)c3nc2-c2ccc(C)cc2)cc1,,C1CCOC1,,,,val
US05088978,BrCc1ccccc1.OCCCCc1ccc(O)cc1>>OCCCCc1ccc(OCc2ccccc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040133008A1,Cc1ccc(C(=O)Nc2ccc(OCCc3cccc(NC(=O)OC(C)(C)C)n3)cc2)c(OC(C)C)c1>>Cc1ccc(C(=O)Nc2ccc(OCCc3cccc(N)n3)cc2)c(OC(C)C)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040092556A1,NCCC[C@H](NC(=O)c1ccc(CNCc2ccccn2)s1)C(=O)O.O=C1CCCc2cccnc21>>O=C(N[C@@H](CCCNC1CCCc2cccnc21)C(=O)O)c1ccc(CNCc2ccccn2)s1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20130317065A1,COC(=O)c1cccc(C=O)n1.COc1cc2[nH]c(C3(C)CC3)cc2cc1C>>COC(=O)c1cccc(Cc2c(C3(C)CC3)[nH]c3cc(OC)c(C)cc23)n1,,CCOC(C)=O,ClCCl,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20090264650A1,BrCC1CC1.O=C1NCCC1c1ccccc1>>O=C1C(c2ccccc2)CCN1CC1CC1,,O,,CN(C)C=O,[H-].[Na+],val
US20040167171A1,Cc1c(C)c(N2CCNCC2)c(C)c2c1OC(C)(C)C2N1CCCC1.Cl.Fc1ccc(CCl)cc1>>Cc1c(C)c(N2CCN(Cc3ccc(F)cc3)CC2)c(C)c2c1OC(C)(C)C2N1CCCC1.Cl.Cl,,CCOC(C)=O,,,,val
US20060205952A1,COc1cc2ccc(C#N)cc2cc1C#N>>N#Cc1ccc2cc(O)c(C#N)cc2c1,,c1ccccc1,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20120214766A1,CCOC(=O)c1nn(-c2cc(Br)ccn2)c2c1C[C@H]1C[C@@H]21>>O=C(O)c1nn(-c2cc(Br)ccn2)c2c1C[C@H]1C[C@@H]21,,C1CCOC1,CO,[Na+].[OH-],,val
US20140018533A1,CCOC(=O)C1=C(N(C)CCO)OCC1=O.COCCOCCl>>CCOC(=O)C1=C(N(C)CCOCOCCOC)OCC1=O,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US06218538B1,CN1CCN(CCO)CC1.O=C(CCl)CC(=O)OCCCc1ccccc1>>CN1CCN(CCOCC(=O)CC(=O)OCCCc2ccccc2)CC1,,C1CCOC1,,Cl,[H-].[Na+],val
US20090209561A1,CCCCn1c(=O)n(CCCCC(=O)OC)c(=O)c2[nH]c(C(F)(F)F)nc21.NC(=NO)c1ccccc1>>CCCCn1c(=O)n(CCCCc2nc(-c3ccccc3)no2)c(=O)c2[nH]c(C(F)(F)F)nc21,,CCO,CCOC(C)=O,C,C[O-].[Na+],val
US05547967,CNCc1ccccc1.ClCCCBr>>CN(CCCCl)Cc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080300266A1,C[Al](C)C.Fc1cnc(N2CC[C@H](NCc3ccc(Cl)cc3Cl)C2)nc1Cl>>Cc1nc(N2CC[C@H](NCc3ccc(Cl)cc3Cl)C2)ncc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,,,val
US20150308956A1,CC(C)(C)O.CC1(C)OBOC1(C)C.CCCC1(CCC)c2cc(Br)ccc2-c2ccc(I)cc21.Cc1ccccc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCCCC(CC)COc1ccc(-c2ccc3c(c2)C(CCC)(CCC)c2cc(Br)ccc2-3)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,O=C([O-])[O-].[K+].[K+],,val
US20080119442A1,CC(C)(C)OC(=O)N(CC=CCl)c1ccc2cc(S(C)(=O)=O)ccc2c1Br>>CC(C)(C)OC(=O)N1CC(CCl)c2c1ccc1cc(S(C)(=O)=O)ccc21,,c1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US20090233920A1,CC(C)(C)CC(=O)Cl.N[C@@H]1C[C@H](C(=O)N(Cc2cccc(Cl)c2Cl)C2CC2)CN(C(=O)OCC2c3ccccc3-c3ccccc32)C1>>CC(C)(C)CC(=O)N[C@H]1CNC[C@@H](C(=O)N(Cc2cccc(Cl)c2Cl)C2CC2)C1,,CC#N,,Cl,,val
US20150336949A1,NC(=O)CCl.O=[N+]([O-])c1cc(Br)ccc1N1CCNCC1>>NC(=O)CN1CCN(c2ccc(Br)cc2[N+](=O)[O-])CC1,,CCO,Cc1ccccc1,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20110086759A1,COC(=O)CBr.Cc1c(O)nc(C2CC2)nc1O>>COC(=O)COc1nc(C2CC2)nc(O)c1C,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US03956310,Cc1ccc(N=C=O)cc1.O=C1NC2(CCCCC2)NC12CCCCC2>>Cc1ccc(NC(=O)N2C(=O)C3(CCCCC3)NC23CCCCC3)cc1,,c1ccccc1,,C1CN2CCN1CC2,,val
US20060199804A1,Clc1cc(-c2ccco2)nc(Cl)n1.O=C1CCC(=O)N1Br>>Clc1cc(-c2ccc(Br)o2)nc(Cl)n1,,CCOC(C)=O,CN(C)C=O,,,val
US05250517,C=C[C@@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cncn1C(=O)OC(C)(C)C)N(C)C(=O)C(=O)OC(C)(C)C)C(C)C>>C=C[C@@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]cn1)N(C)C=O)C(C)C,,C1COCCO1,Cl,CCOCC,,val
US20070015774A1,CN(C)CCCN.Clc1nc(CN(Cc2ccccc2)Cc2ccccc2)nc2ccccc12>>CN(C)CCCNc1nc(CN(Cc2ccccc2)Cc2ccccc2)nc2ccccc12,,CCO,,,,val
US20060183762A1,CCO.O=C(O)c1c(F)cc(F)c(F)c1F>>CCOC(=O)c1c(F)cc(F)c(F)c1F,CN(C)C=O,ClCCl,c1ccccc1,O=C(Cl)C(=O)Cl,O=C([O-])O.[Na+],val
US05420151,CCC(=O)CC.COc1ccc(F)c2c1C[C@@H](N)CO2.[BH3-]C#N>>CCC(CC)N[C@H]1COc2c(F)ccc(OC)c2C1.N,,CO,,CC(=O)O,,val
US20100179128A1,Nc1ccccc1O.O=C(Cl)CCCCCCl>>O=C(CCCCCCl)Nc1ccccc1O,,CCOC(C)=O,,CCN(CC)CC,,val
US20130059883A1,CCc1cc(Br)cc(C(=O)OC)c1.N#C[Cu]C#N>>CCc1cc(C#N)cc(C(=O)OC)c1,,CN(C)C=O,,,,val
US04973353,CC(C)CCOCc1cc(NN=C2N=C(c3ccccc3F)OC2=O)ccc1Cl.N>>CC(C)CCOCc1cc(-n2nc(C(N)=O)nc2-c2ccccc2F)ccc1Cl,,CC(C)=O,,Cl,O,val
US20040176608A1,CC(C)Br.O=Cc1cccc(-c2ccccc2)c1O>>CC(C)Oc1c(C=O)cccc1-c1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US06018046,CCOC(=O)c1cn2c3ccc(Br)cc3c3cc(OC)cc(c1=O)c32>>COc1cc2c(=O)c(C(=O)O)cn3c4ccc(Br)cc4c(c1)c23,,CCO,,[Na+].[OH-],,val
US20060052445A1,O=Cc1ccccc1S(=O)(=O)c1ccc(/C=C/c2ccc(F)cc2F)cc1>>O=S(=O)(c1ccc(/C=C/c2ccc(F)cc2F)cc1)c1ccccc1CO,,CO,ClCCl,[BH4-].[Na+],,val
US20090318493A1,CCCC1(C(=O)c2cc3cc(F)ccc3[nH]2)CCN(C(=O)OC(C)(C)C)CC1>>CCCC1(C(=O)c2cc3cc(F)ccc3[nH]2)CCNCC1,,Cl,,,,val
US05656260,BrCc1ccccc1.COC(CCCC(C)O)OC>>COC(CCCC(C)OCc1ccccc1)OC,,CN(C)C=O,,,,val
US20040127494A1,CC(C)C[C@H](C(N)=O)N(CC(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Cl)cc1>>CC(C)C[C@H](C(N)=O)N(CC(=O)O)S(=O)(=O)c1ccc(Cl)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040106604A1,C=O.CO.Cc1cccc(-c2nn3c(c2-c2ccnc4cc(C(=O)NC(C)(C)CN)ccc24)CCC3)n1>>Cc1cccc(-c2nn3c(c2-c2ccnc4cc(C(=O)NC(C)(C)CN(C)C)ccc24)CCC3)n1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20030158405A1,CCOC(=O)CCc1ccc(S(=O)(=O)CCc2c(CCNS(=O)(=O)Cc3ccccc3Cl)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1>>O=C(O)CCc1ccc(S(=O)(=O)CCc2c(CCNS(=O)(=O)Cc3ccccc3Cl)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1,,CO,,C1CCOC1,[Na+].[OH-],val
US06043246,COc1ccc(C(=O)CC#N)cc1OC.NN>>COc1ccc(-c2cc(N)n[nH]2)cc1OC,,CCO,,O,,val
US20140275528A1,CNC.Cn1c(=O)c2c(nc(Oc3cccc(OC(F)(F)F)c3)n2Cc2ccc(CCl)cc2)n(C)c1=O>>CN(C)Cc1ccc(Cn2c(Oc3cccc(OC(F)(F)F)c3)nc3c2c(=O)n(C)c(=O)n3C)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130225589A1,CC(=O)O.CCOC(=O)C(Cl)C(=O)CC>>CCOC(=O)C(OC(C)=O)C(=O)CC,,CN(C)C=O,,CCN(CC)CC,O,val
US20120094972A1,CC1(C)CNc2cc(I)ccc21.Cc1c(-c2ccccc2S(C)(=O)=O)nc2cc(F)ccc2c1Cl>>Cc1c(-c2ccccc2S(C)(=O)=O)nc2cc(F)ccc2c1N1CC(C)(C)c2ccc(I)cc21,,CN1CCCC1=O,,Cl,,val
US20060004013A1,COc1cc(/C=C(\CCO)C(=O)OC(C)(C)C)ccc1-n1cnc(C)c1.O=C1NC(=O)c2ccccc21>>COc1cc(/C=C(\CCN2C(=O)c3ccccc3C2=O)C(=O)OC(C)(C)C)ccc1-n1cnc(C)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06498185B1,CC(C)(C)C(=O)Cl.O=C(Nc1ccccc1)c1cc(O)c(O)cc1NC(=O)c1sc2ccccc2c1Cl>>CC(C)(C)C(=O)Oc1ccc(C(N)=O)cc1O,,ClCCl,c1ccncc1,,,val
US20110065764A1,CCOC(=O)c1noc(-c2ccc(Cl)cc2)c1Cl>>O=C(O)c1noc(-c2ccc(Cl)cc2)c1Cl,,CO,,Cl,[Na+].[OH-],val
US20140252279A1,Brc1cscc1Br.CCCCCCCCCC(CCCCCCC)C(=O)Cl>>CCCCCCCCCC(CCCCCCC)C(=O)c1scc(Br)c1Br,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20160152570A1,CCO[C@H](Cc1ccc(OCC(=O)c2cccc(OC)c2)cc1)C(=O)O.CO[NH3+]>>CCO[C@H](Cc1ccc(OCC(=O)c2cccc(OC)c2)cc1)C(=O)NOC,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04010177,C#CCN.Fc1ccc2c(c1)C(c1ccccc1Cl)=NCc1nnc(CBr)n1-2>>C#CCNCc1nnc2n1-c1ccc(F)cc1C(c1ccccc1Cl)=NC2,,CN(C)C=O,,[I-].[K+],,val
US20090239854A1,C=Cc1ccc(Cl)cc1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>Cc1ccc2c(c1)c1c(n2CCc2ccc(Cl)cc2)CCN(C)C1,,CN(C)C=O,,[H-].[Na+],,val
US20050020684A1,CO[C@](C(=O)O[C@@H]1CCC[C@H](Oc2ccc(-c3ccccc3)cc2)C1)(c1ccccc1)C(F)(F)F>>O[C@@H]1CCC[C@H](Oc2ccc(-c3ccccc3)cc2)C1,,CCO,,[Na+].[OH-],,val
US20150307449A1,CN(Cc1cc(-c2ccccc2F)n(S(=O)(=O)c2cccc(OCC(N)=O)c2)c1)C(=O)OC(C)(C)C>>CNCc1cc(-c2ccccc2F)n(S(=O)(=O)c2cccc(OCC(N)=O)c2)c1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20080287409A1,N#Cc1cc(F)c(F)cc1F.OCc1sc(-c2ccc(C(F)(F)F)cc2)nc1CN1CCC(C(F)(F)F)CC1>>N#Cc1cc(F)c(OCc2sc(-c3ccc(C(F)(F)F)cc3)nc2CN2CCC(C(F)(F)F)CC2)cc1F,,C1CCOC1,CC(C)(C)O,O,CC(C)(C)[O-].[K+],val
US20020077318A1,CC(C)O.CCN(CC)CC>>CC(C)O.CCNCC,,C1CCOC1,CC(C)O,CCCCCCC,,val
US20030125494A1,CC(C)(C)C(=O)Cl.CCC1(CC)NC(C)(CO)COC1=O>>CCC1(CC)NC(C)(COC(=O)C(C)(C)C)COC1=O,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20100216814A1,CC(=CBr)c1ccc(C)nc1.CN1CCc2[nH]c3ccccc3c2C1>>C/C(=C\n1c2c(c3ccccc31)CN(C)CC2)c1ccc(C)nc1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US04342781,CCCCCCCCCC(C)NC(=O)C=C(c1ccccc1)c1ccc([N+](=O)[O-])cc1>>CCCCCCCCCC(C)NC(=O)C=C(c1ccccc1)c1ccc(N)cc1,[Fe],CC(=O)O,,,,val
US20060257337A1,CI.COc1cc(Br)c(O)cc1OCc1ccccc1>>COc1cc(OCc2ccccc2)c(OC)cc1Br,,O,,[H-].[Na+],,val
US06174839B1,CI.Cc1c(C(F)(F)F)[nH]c(=O)n(-c2ccc(Br)cc2F)c1=O>>Cc1c(C(F)(F)F)n(C)c(=O)n(-c2ccc(Br)cc2F)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120165305A1,N#C/C=C/C(F)(F)F.O=C(NCC(F)(F)F)Nc1cccc(-n2cnc3cc(-c4cn[nH]c4)ccc32)c1>>N#CCC(n1cc(-c2ccc3c(c2)ncn3-c2cccc(NC(=O)NCC(F)(F)F)c2)cn1)C(F)(F)F,,CC#N,,C1CCC2=NCCCN2CC1,Cl,val
US04024272,CN(C)C(=S)Cl.COc1cc(O)cc(OC)c1>>COc1cc(OC)cc(OC(=S)N(C)C)c1,,CN(C)C=O,,[H-].[Na+],,val
US20120277224A1,CCOC(=O)CC(=O)c1ccc2c(cnn2C)c1.Nc1n[nH]c(N)c1-c1ccccn1>>Cn1ncc2cc(-c3cc(=O)n4nc(N)c(-c5ccccn5)c4[nH]3)ccc21,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060194843A1,N[C@H]1CC[C@H](O)CC1.O=C(O)c1n[nH]cc1[N+](=O)[O-]>>O=C(NC1CCC(O)CC1)c1n[nH]cc1[N+](=O)[O-],,CN(C)C=O,ClCCl,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20130267510A1,CC1OCc2cccc(Oc3ccc([N+](=O)[O-])cn3)c21>>CC1OCc2cccc(Oc3ccc(N)cn3)c21,[Pd],CCO,,NN,O,val
US20100216792A1,CCOC(=O)c1sc(Cl)nc1C(F)(F)F.FC(F)(F)C1(c2cc(Cl)c(Cl)c(Cl)c2)CCNC1>>CCOC(=O)c1sc(N2CCC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)nc1C(F)(F)F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05155240,C=CC=COC(=O)N(C)C.COC(=O)C=O>>COC(=O)C1CC=CC(OC(=O)N(C)C)O1,,O=C([O-])O,[Na+],,,val
US20080188565A1,C=CCI.Cc1cc(OCC(=O)N2C(=O)OC[C@@H]2Cc2ccccc2)ccc1F>>C=CC[C@@H](Oc1ccc(F)c(C)c1)C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US04529726,CCC(=O)Cl.O=[N+]([O-])C=C1NCCCS1>>CCC(=O)N1CCCSC1=C[N+](=O)[O-],,CN(C)C=O,,CCN(CC)CC,Cl,val
US20050192300A1,CNc1nc(C)c(-c2ccnc(Nc3cccc(CN)c3)n2)s1.CS(=O)(=O)Cl>>CNc1nc(C)c(-c2ccnc(Nc3cccc(CNS(C)(=O)=O)c3)n2)s1,,CC#N,,,,val
US05536717,C#CCBr.O=C1Nc2cc(Br)ccc2N2CCc3cccc1c32>>C#CCN1C(=O)c2cccc3c2N(CC3)c2ccc(Br)cc21,,CN(C)C=O,,O,[H-].[Na+],val
US04537903,COc1ccc(O)c(CC=Cc2ccccc2C=O)c1>>COc1ccc(O)c(CC=Cc2ccccc2CO)c1,,CO,,[BH4-].[Na+],,val
US20160016948A1,CCOC(=O)C(C)(C)Cn1ccc2cnc(Nc3ccnc(N4CCC(OC)CC4)n3)cc21>>COC1CCN(c2nccc(Nc3cc4c(ccn4CC(C)(C)C(=O)O)cn3)n2)CC1,,CO,O,[Li+].[OH-],,val
US20080166358A1,COCCOc1cc(N)c(C(=O)OC)cc1OCCOC.NC=O>>COCCOc1cc2nc[nH]c(=O)c2cc1OCCOC,,CN1CCCC1=O,,,,val
US20120142691A1,CC(C)(C)OC(=O)N1CCC[C@@H]1COS(C)(=O)=O.N#Cc1ncccc1O>>CC(C)(C)OC(=O)N1CCC[C@@H]1COc1cccnc1C#N,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120232088A1,O=c1[nH]c(=Cc2ccc(O)cn2)c(=O)[nH]c1=CCc1ccccc1>>O=C1NC(Cc2ccccc2)C(=O)N/C1=C\c1ccc(O)cn1,[Zn],CN(C)C=O,,[Cl-].[NH4+],,val
US20120277224A1,CCO.Cn1ncc2cc(C(=O)C3C(=O)OC(C)(C)OC3=O)ccc21>>CCOC(=O)CC(=O)c1ccc2c(cnn2C)c1,,CCO,,,,val
US20040259916A1,N#CC1(c2ccc(N)cc2)CCC1.Nc1ccccc1C(=O)O>>N#CC1(c2ccc(NC(=O)c3ccccc3N)cc2)CCC1,,ClCCl,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20090054644A1,CC(Oc1ccc(C#N)cn1)C1CNCC1c1ccc(Cl)c(Cl)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(Oc1ccc(C#N)cn1)C1CN(C(=O)Cl)CC1c1ccc(Cl)c(Cl)c1,,ClCCl,,CCOC(C)=O,c1ccncc1,val
US20130217663A1,CCN=C=NCCCN(C)C.CCO.N.O=C([O-])O.O=Cc1ccc(-c2ncc(Br)s2)cc1Cl.On1nnc2ccccc21>>CC(C)Oc1ccc(-c2cnc(-c3ccc(CN4CC(C(N)=O)C4)cc3)s2)cc1,,ClC(Cl)Cl,,CN(C)C=O,,val
US20030130270A1,COc1ccc2c(c1)CN(C(=O)OC(C)(C)C)CC2>>COc1ccc2c(c1)CNCC2,,CCOCC,,Cl,,val
US20090324581A1,Cc1nc(-c2ccccc2)c(C(F)(F)F)o1.O=C1CCC(=O)N1Br>>FC(F)(F)c1oc(CBr)nc1-c1ccccc1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US04052455,COc1ccc(C(Cl)=NS(=O)(=O)C=Cc2ccc(Cl)c(Cl)c2)cc1OC.N>>COc1ccc(C(=N)NS(=O)(=O)C=Cc2ccc(Cl)c(Cl)c2)cc1OC,,c1ccccc1,,,,val
US20080280923A1,COCCN.N#Cc1ccc2c(c1)cc(C(=O)O)n2Cc1cccc(OC(F)(F)F)c1>>COCCNC(=O)c1cc2cc(C#N)ccc2n1Cc1cccc(OC(F)(F)F)c1,,ClCCl,,CCN(CC)CC,O=S(Cl)Cl,val
US20120329830A1,CCOC(C)=O.COc1ccc(CN)cc1.O=C([O-])CCc1nc2cc(Br)ccc2nc1Cl>>COC(=O)CCc1nc2cc(Br)ccc2nc1NCc1ccc(OC)cc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20070219228A1,CC(C)(C)[Si](C)(C)OCc1cncc(B(O)O)c1.CCOCc1nc2c(N)nc3cc(Br)cnc3c2n1CC(C)(C)O>>CCOCc1nc2c(N)nc3cc(-c4cncc(CO[Si](C)(C)C(C)(C)C)c4)cnc3c2n1CC(C)(C)O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20070155805A1,CCCCC(CCBr)c1sc2cc(C(F)(F)F)ccc2c1C.CCOC(=O)Cc1ccc(O)c(OC)c1>>CCCCC(CCOc1ccc(CC(=O)OCC)cc1OC)c1sc2cc(C(F)(F)F)ccc2c1C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050256201A1,CC(C)(C)[Si](C)(C)Oc1ccc(CCO)cc1.CS(=O)(=O)Cl>>CC(C)(C)[Si](C)(C)Oc1ccc(CCOS(C)(=O)=O)cc1,,ClCCl,O,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20060287362A1,CN1CCC[C@H]1CO.COC(=O)C(O)(c1ccccc1)c1ccccc1>>CN1CCC[C@H]1COC(=O)C(O)(c1ccccc1)c1ccccc1,,Cc1ccccc1,,[Na],,val
US20040044057A1,CCOC(=O)C(C)(C)Br.O=C1CCCc2c1ccc(O)c2CCc1ccccc1>>CCOC(=O)C(C)(C)Oc1ccc2c(c1CCc1ccccc1)CCCC2=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090286778A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc(Br)cc(C(=O)O)c1>>CC(C)(C)OC(=O)Nc1cc(Br)cc(C(=O)O)c1,,C1COCCO1,O,CCN(CC)CC,,val
US20020198200A1,CN=C=O.NC(=O)C(OC1CCCCC1)c1ccc(Cl)c(Cl)c1>>CNC(=O)NC(=O)C(OC1CCCCC1)c1ccc(Cl)c(Cl)c1,,Cc1ccccc1,,,,val
US20060247251A1,Cl.O=C1CC2(CCNCC2)C(=O)N1>>Cl.O=C1CC2(CCNCC2)C(=O)N1,,CCO,,C1COCCO1,,val
US20140275061A1,c1cc2c(c(-c3ccncc3)c1)CCNC2>>C1=NCCc2c1cccc2-c1ccncc1,O=[Mn]=O,,,,,val
US20050059713A1,COc1ccc(Br)cc1CCNC(=O)c1cc2ccccc2cc1O.O=[N+]([O-])c1ccc(B(O)O)cc1>>COc1ccc(-c2ccc([N+](=O)[O-])cc2)cc1CCNC(=O)c1cc2ccccc2cc1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20100286173A1,Cc1ccc(C(=NO)c2nnnn2C)cc1C(F)(F)F.Nc1nc(CCl)cs1>>Cc1ccc(C(=NOCc2csc(N)n2)c2nnnn2C)cc1C(F)(F)F,,C1CCOC1,C1CCOC1,Cl,,val
US20110224447A1,CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OCCCCCCCCOS(C)(=O)=O)CC[C@]4(C)[C@H]3CC[C@]12C.CCCCC/C=C\C/C=C\CCCCCCCCOC[C@H](O)CN(C)C>>CCCCC/C=C\C/C=C\CCCCCCCCOC[C@@H](CN(C)C)OCCCCCCCCO[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CC[C@H]([C@H](C)CCCC(C)C)[C@@]4(C)CC[C@@H]32)C1,,Cc1ccccc1,,CCO,[H-].[Na+],val
US20100063285A1,C[C@@H]1O[C@@]1(Cn1cncn1)c1ccc(F)cc1F.O=[N+]([O-])c1cn[nH]c1>>C[C@@H](n1cc([N+](=O)[O-])cn1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070099915A1,C[Si](C)(C)CCOCON.O=C1OCCc2c1ncc1c2ccn1Cc1ccc(F)cc1>>C[Si](C)(C)CCOCONC(=O)c1ncc2c(ccn2Cc2ccc(F)cc2)c1CCO,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US06121280,COc1cc(CCCCC(=O)C2NC3C=CC2C3)cc(OC)c1OC>>COc1cc(CCCCC(=O)C2NC3CCC2C3)cc(OC)c1OC,[Pd],CCOC(C)=O,,,,val
US06110937,CN1CCC[C@@H](CO)C1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC[C@@H]2CCCN(C)C2)cc1,,ClCCl,,,,val
US06740647B1,COC(=O)c1nc(CNC(=O)OC(C)(C)C)sc1C>>Cc1sc(CNC(=O)OC(C)(C)C)nc1C(=O)O,,CCO,O,[Li+].[OH-],,val
US06358971B1,O=C(c1ccccc1)c1ccc2nc(NC(=O)C(F)(F)F)c(-c3ccc(C(F)(F)F)cc3F)n2c1>>Nc1nc2ccc(C(=O)c3ccccc3)cn2c1-c1ccc(C(F)(F)F)cc1F,,CCOC(C)=O,,,,val
US04115416,CCCCCCCCCCC(Br)C(=O)OCC.Oc1ccc(C2=CCCCC2)cc1>>CCCCCCCCCCC(Oc1ccc(C2=CCCCC2)cc1)C(=O)OCC,,CCO,,[Na],,val
US06140100,CCOC(=O)CCC(N)C(=O)O.O=C(Cl)OCc1ccccc1>>CCOC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)O,,O,,O=C([O-])O.[Na+],,val
US20100317865A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)[C@@](C)(CCCBr)C(=O)OC1CCCC1.Nc1c(C(=O)c2ccc(F)cc2F)ccc(=O)n1-c1c(F)cc(O)cc1F>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)[C@@](C)(CCCOc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)OC1CCCC1,,CCOC(C)=O,CN(C)C=O,[I-].[K+],O=C([O-])O.[Na+],val
US04992454,CC(n1cncn1)C1(c2ccc(F)cc2)CO1.c1nc[nH]n1>>CC(n1cncn1)C(O)(Cn1cncn1)c1ccc(F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060069255A1,Nc1cc(Cl)ccc1C(=O)O.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1cc(Cl)ccc1C(=O)O,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20090105231A1,CCOC(=O)C(CNC(=O)OC(C)(C)C)Cc1ccccc1>>CC(C)(C)OC(=O)NCC(Cc1ccccc1)C(=O)O,,C1CCOC1,,Cl,[Na+].[OH-],val
US05741785,CCOC(=O)c1nc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n2c1CP(=O)(O)O>>O=C(O)c1nc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n2c1CP(=O)(O)O,,Br,,,,val
US20090005558A1,N#Cc1ccc(OCCN2CC3CN(CCN)CC(C2)O3)c(F)c1.O=S(=O)(Cl)c1ccc(F)cc1F>>N#Cc1ccc(OCCN2CC3CN(CCNS(=O)(=O)c4ccc(F)cc4F)CC(C2)O3)c(F)c1,,ClCCl,,CCN(CC)CC,Cl,val
US20100075948A1,CC(C)(C)C/C=N/CC(=O)OC(C)(C)C.N#C/C(=C\c1ccc(C(F)(F)F)c(Cl)c1)c1ccc(Cl)cc1F>>CC(C)(C)CC1NC(C(=O)OC(C)(C)C)C(c2ccc(C(F)(F)F)c(Cl)c2)C1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(CC)CC,,val
US20100111900A1,COc1cc(Cn2c(=O)n(C)c3ccccc32)c(-c2cccnc2OCc2ccccc2)cc1C(C)(C)C>>COc1cc(Cn2c(=O)n(C)c3ccccc32)c(-c2ccc[nH]c2=O)cc1C(C)(C)C,[Pd],CO,,,,val
US20080188467A1,CO.COC(OC)OC.O=Cc1ccc(I)cc1>>COC(OC)c1ccc(I)cc1,Cc1ccc(S(=O)(=O)O)cc1,CO,,,,val
US20160237075A1,CNC(=O)c1sc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1-c1ccc(Oc2ccccc2)cc1>>CNC(=O)c1sc(N2CCNCC2)nc1-c1ccc(Oc2ccccc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040033896A1,Cc1cnc(-c2ccc(C(F)(F)F)cc2)nc1.[Li]C>>Cc1cnc(-c2ccc(C(F)(F)F)cc2)nc1C,,C1CCOC1,,O,,val
US20120214837A1,CCOc1ccc2cc(CO)cnc2c1.O=S(Cl)Cl>>CCOc1ccc2cc(CCl)cnc2c1.Cl,,ClCCl,,,,val
US20090012117A1,Nc1nccs1.O=CN1CCCc2cc(S(=O)(=O)Cl)ccc21>>O=CN1CCCc2cc(S(=O)(=O)Nc3nccs3)ccc21,,c1ccncc1,,,,val
US20060025456A1,C=[N+](C)C.O=C1CCSCC1.[Cl-]>>CN(C)CC1CSCCC1=O.Cl,,CC#N,,CC(=O)Cl,,val
US20120232056A1,COC(=O)c1ccc2nc(OS(=O)(=O)C(F)(F)F)c(N3CCCCCC3)nc2c1.OB(O)c1cc2ccccc2s1>>COC(=O)c1ccc2nc(-c3cc4ccccc4s3)c(N3CCCCCC3)nc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20110212053A1,O=P(Cl)(Cl)Cl.O=[N+]([O-])c1cnc2ccc(Br)cc2c1O>>O=[N+]([O-])c1cnc2ccc(Br)cc2c1Cl,,CC#N,,CCN(C(C)C)C(C)C,,val
US20160024021A1,CCn1cc(Nc2ncc(CCc3cc(C(=O)OC)cc(OC)c3F)cn2)cn1>>CCn1cc(Nc2ncc(CCc3cc(C(=O)O)cc(OC)c3F)cn2)cn1,,CO,,[Na+].[OH-],,val
US20100168418A1,CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCNCC1.O=CCn1c(=O)cnc2ccc(F)cc21>>CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCN(CCn2c(=O)cnc3ccc(F)cc32)CC1,,CC(=O)O,ClC(Cl)Cl,O=C([O-])O.[Na+],,val
US20150050659A1,C#CCOc1cc(C(=O)OC)cc(OCC#C)c1CCCNC(=O)OC(C)(C)C>>C#CCOc1cc(C(=O)O)cc(OCC#C)c1CCCN,,C1COCCO1,,[Na+].[OH-],,val
US06265411B1,COc1cc2c(Cl)ncnc2cc1OCCCN1CCOCC1.O=C1Cc2cc([N+](=O)[O-])ccc2N1>>COc1cc2c(C3C(=O)Nc4ccc([N+](=O)[O-])cc43)ncnc2cc1OCCCN1CCOCC1.Cl,,C1CCOC1,,CN(C)C=O,[H-].[Na+],val
US20080153810A1,CN(C)C(=O)CN(C)c1n[nH]c2ccc(N)cc12.O=C(O)Cc1ccc(Oc2ccccc2)cc1.On1nnc2ccccc21>>CN(C)C(=O)CN(C)c1n[nH]c2ccc(NC(=O)Cc3ccc(OCc4ccccc4)cc3)cc12,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,ClCCCl,val
US20050143452A1,Cc1ccccc1-c1cccc2c1OC(CN=[N+]=[N-])C2>>Cc1ccccc1-c1cccc2c1OC(CN)C2,[Pd],,,,,val
US20090286778A1,CC(C)(C)OC(=O)Nc1cccc(N)c1.O=C(Cl)c1cccc([N+](=O)[O-])c1>>CC(C)(C)OC(=O)Nc1cccc(NC(=O)c2cccc([N+](=O)[O-])c2)c1,,C1CCOC1,,CCN(CC)CC,O=C([O-])[O-].[Na+].[Na+],val
US20120245161A1,COC(=O)c1cn(CCCN2CCOCC2)c2c(C)cccc12>>Cc1cccc2c(C(=O)O)cn(CCCN3CCOCC3)c12,,CO,,Cl,[Na+].[OH-],val
US20150353499A1,BrP(Br)Br.Cc1cc(CO)ccc1-c1ccccc1>>Cc1cc(CBr)ccc1-c1ccccc1,,ClCCl,,,,val
US20120142662A1,Cc1ccc(/C=C(/C#N)c2cccc(F)c2)cc1C>>Cc1ccc(CC(C#N)c2cccc(F)c2)cc1C,,CCO,,[BH4-].[Na+],,val
US20070232590A1,O=C1CCCC1.O=C1CCCN1c1ccc(Oc2ccc3c(c2)CCNCC3)nc1>>O=C1CCCN1c1ccc(Oc2ccc3c(c2)CCN(C2CCCC2)CC3)nc1,,CO,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080015199A1,CC(C)(C)[Si](C)(C)OCCCBr.COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(OC)cc(O)c1F>>COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(OC)cc(OCCCO[Si](C)(C)C(C)(C)C)c1F,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070249614A1,O=C1CC2(CCCCC2)Oc2c(Cl)cc(Cl)cc21.c1ccncc1>>NC1CC2(CCCCC2)Oc2c(Cl)cc(Cl)cc21,,CO,,O,[K+].[OH-],val
US20050070559A1,COCCOCCOc1ccc2c(=O)[nH]cnc2c1.O=C(Cl)C(=O)Cl>>COCCOCCOc1ccc2c(Cl)ncnc2c1,,ClCCl,,CS(C)=O,,val
US20020068756A1,CCOC(=O)c1[nH]c2ccc(Br)cc2c1OCc1ccccc1.Fc1ccc(CBr)cc1>>CCOC(=O)c1c(OCc2ccccc2)c2cc(Br)ccc2n1Cc1ccc(F)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20080096889A1,CC(C)(C)OC(=O)C=Cc1ccc(C=CC(=O)c2cccnc2)cc1>>O=C(O)C=Cc1ccc(C=CC(=O)c2cccnc2)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20060135578A1,CCOP(=O)(CP(=O)(OCC)OCC)OCC.COc1cc(C(=O)Nc2nn(-c3ccccc3)cc2C=O)ccc1OCc1nc(-c2ccco2)oc1C>>CCOP(=O)(/C=C/c1cn(-c2ccccc2)nc1NC(=O)c1ccc(OCc2nc(-c3ccco3)oc2C)c(OC)c1)OCC,,CN(C)C=O,,O,[H-].[Na+],val
US20090227588A1,O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)nc1)c1cccc([N+](=O)[O-])c1>>Nc1cccc(C(=O)Nc2ccc(-n3nc(-c4cccnc4)cc3C(F)(F)F)nc2)c1,[Pd],CCO,,,,val
US20070004772A1,Cc1ccc(-c2ccnc(NN)c2Cl)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1ccc(-c2ccn3c(=O)[nH]nc3c2Cl)cc1,,C1CCOC1,,,,val
US20150376212A1,COC(=O)c1ccc(Oc2ccccc2Br)cc1>>O=C(O)c1ccc(Oc2ccccc2Br)cc1,,O,,CO,[Na+].[OH-],val
US20090048290A1,O=C(N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1)c1cc2ccccc2o1.O=C(O)/C=C\C(=O)O>>O=C(N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1)c1cc2ccccc2o1.O=C(O)/C=C\C(=O)O,,CC(=O)OC(C)C,,CC(C)O,,val
US20140243353A1,COCOc1cc(SCc2cccc(F)c2)cnc1OCOC>>O=c1[nH]cc(SCc2cccc(F)c2)cc1O,,C1COCCO1,,Cl,,val
US20040204584A1,COc1ccc(C2COCCO2)c2sc(N)nc12.O=C(O)c1ccc(F)cc1F>>COc1ccc(C2COCCO2)c2sc(NC(=O)c3ccc(F)cc3F)nc12,,C1CCOC1,ClC(Cl)Cl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150133490A1,NC1CCc2ccc(F)cc21.O=[N+]([O-])c1ccc(Cl)nc1Cl>>O=[N+]([O-])c1ccc(Cl)nc1NC1CCc2ccc(F)cc21,,CO,,CCN(CC)CC,,val
US20050085465A1,COc1cc2c(Cl)ncnc2cc1OCCCN1CCN(CCF)CC1.Cc1cc2cc(O)ccc2[nH]1>>COc1cc2c(Oc3ccc4[nH]c(C)cc4c3)ncnc2cc1OCCCN1CCN(CCF)CC1,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US07666888B2,COC(=O)c1ccccc1.Cc1noc(C)c1C(=O)O>>Cc1noc(CC(=O)c2ccccc2)c1C(=O)O,,C1CCOC1,Cc1ccccc1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20070155727A1,COC(=O)c1ccc(CN2CCCNCC2)cc1.O=C(CCl)Nc1ccc(OC(F)(F)F)cc1>>COC(=O)c1ccc(CN2CCCN(CC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20070173506A1,COc1ccc(CC(N)CNc2ncc(-c3ccc4[nH]c(=O)oc4c3)s2)cc1F>>NC(CNc1ncc(-c2ccc3ncoc3c2)s1)Cc1ccc(O)c(F)c1,,ClCCl,,BrB(Br)Br,,val
US20150353533A1,CCOC(=O)c1c[nH]cn1.Fc1cccc(CBr)c1>>CCOC(=O)c1cn(Cc2cccc(F)c2)cn1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20160200704A1,COC(=O)c1cc(I)c2ncccc2c1.O=C1CCC(=O)N1Cl>>COC(=O)c1cc(I)c2ncc(Cl)cc2c1,,CC(=O)O,,,,val
US20080318922A1,Cn1c(S(C)(=O)=O)nc2c(C#N)c(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)n(Cc3cc(F)ccc3Cl)c2c1=O.[C-]#N>>Cn1c(C#N)nc2c(C#N)c(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)n(Cc3cc(F)ccc3Cl)c2c1=O,,C1CCOC1,,O,,val
US20150291572A1,COC(=O)c1cnc(OC)c(F)c1>>COc1ncc(CO)cc1F,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070037836A1,C=O.CN(C)c1nc(NC[C@@H]2CC[C@@H](CNCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12>>CN(Cc1ccc(Br)cc1OC(F)(F)F)C[C@@H]1CC[C@@H](CNc2nc(N(C)C)c3ccccc3n2)CC1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120202785A1,C=CC(C)N.C=Cc1c(F)ccc([N+](=O)[O-])c1F>>C=Cc1c(F)ccc([N+](=O)[O-])c1NC(C)C=C,,CCO,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20130237535A1,O=C1COC2(CCNCC2)CN1C1CC1.O=S(=O)(Cl)c1cc(F)c(Br)c(F)c1>>O=C1COC2(CCN(S(=O)(=O)c3cc(F)c(Br)c(F)c3)CC2)CN1C1CC1,,ClCCl,,Cl,,val
US20090146139A1,Cc1ccc(-c2c3ccccc3c(-c3ccc4c(c3)C(=O)c3ccc(-c5c6ccccc6c(-c6ccc(C)c7ccccc67)c6ccccc56)cc3C4=O)c3ccccc23)c2ccccc12.Cc1ccccc1-c1ccc2c(c1)C(=O)c1ccc(-c3ccccc3C)cc1C2=O>>Cc1ccccc1-c1c2ccc(-c3c4ccccc4c(-c4ccc(C)c5ccccc45)c4ccccc34)cc2c(-c2ccccc2C)c2ccc(-c3c4ccccc4c(-c4ccc(C)c5ccccc45)c4ccccc34)cc12,,Cc1ccccc1,,,,val
US20120232083A1,C[C@@](CCn1cc(F)c(-c2ccc3c(c2)OC(F)(F)O3)cc1=O)(C(=O)NOC1CCCCO1)S(C)(=O)=O>>C[C@@](CCn1cc(F)c(-c2ccc3c(c2)OC(F)(F)O3)cc1=O)(C(=O)NO)S(C)(=O)=O,,CCO,O,Cl,,val
US20090029903A1,CCCCCCN(Cc1ccc(O)c(C(=O)O)c1)C(=O)c1ccc(C#Cc2ccc(CCCC)cc2)cc1.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>CCCCCCN(Cc1ccc(O)c(C(=O)O)c1)C(=O)c1ccc(C#Cc2ccc(CCCC)cc2)cc1.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,,CO,O,,,val
US04788185,CC(C)(C)OC(=O)CO/N=C(\C(=O)O)c1csc(N)n1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)CO/N=C(\C(=O)O)c1nc(N)sc1Br,,CO,,,,val
US20140031336A1,C1COCCN1.CC(=O)N1c2ccc(-c3ccc(C(=O)O)nc3)cc2[C@H](N)C[C@@H]1C>>CC(=O)N1c2ccc(-c3ccc(C(=O)N4CCOCC4)nc3)cc2[C@H](N)C[C@@H]1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120058989A1,CC(C)(C)OC(=O)NC[C@@H]1C[C@H](NC(=O)OCc2ccccc2)CN1C(=O)OCc1ccccc1.CCOC(=O)C(F)(F)F>>CC(C)(C)OC(=O)NC[C@@H]1C[C@H](NC(=O)C(F)(F)F)CN1,[Pd],C1CCOC1,CO,,,val
US20030220350A1,CCOC(=O)CCNC(=O)c1ccc(C(NC(=O)Nc2ccc(OC(F)(F)F)cc2)[C@H]2CC[C@@H](C(C)(C)C)CC2)cc1>>CC(C)(C)[C@@H]1CC[C@H](C(NC(=O)Nc2ccc(OC(F)(F)F)cc2)c2ccc(C(=O)NCCC(=O)O)cc2)CC1,,CCO,,[Na+].[OH-],,val
US04246270,CCN(CC)S(F)(F)F.CCN1C(=O)C(O)N=C(c2ccccc2)c2cc(Cl)ccc21>>CCN1C(=O)C(F)N=C(c2ccccc2)c2cc(Cl)ccc21,,ClCCl,,O,,val
US20030176698A1,CCCN1C(=O)N2C[C@@H](Cc3ccccc3)N=C2c2c1nc(C(=O)OC)n2Cc1ccccc1.C[Mg]Br>>CCCN1C(=O)N2C[C@@H](Cc3ccccc3)N=C2c2c1nc(C(C)(C)O)n2Cc1ccccc1,,C1CCOC1,,CCOCC,,val
US20020173646A1,COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1O.ClCCl.OC/C=C/CN1CCOCC1>>COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OC/C=C/CN1CCOCC1.Cl,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04466980,CC(C)(C)[Si](C)(C)OC1C=CC(=O)C1.OO>>CC(C)(C)[Si](C)(C)OC1CC(=O)C2OC12,,CO,,[Na+].[OH-],,val
US05698691,CC(C)N.CCCCCC.CCOC(=O)CI.O=C1CCC(c2ccccc2Cl)c2cc(Cl)ccc2N1>>CCOC(=O)CC1CC(c2ccccc2Cl)c2cc(Cl)ccc2N(CC(C)C)C1=O,,C1CCOC1,CCCCCC,Cl,[Li]CCCC,val
US20160007598A1,CC1=C(C(F)F)C(O)CC(C)(C)C1(O)C#C/C(C)=C\CO>>CC1=C(C(F)F)C(O)CC(C)(C)C1(O)/C=C/C(C)=C\CO,,C1CCOC1,,Cc1ccccc1,O,val
US20150322048A1,COC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@@H]1CCCOC1>>COC(=O)N[C@H](C(=O)OC)[C@@H]1CCCOC1,[Pd],CO,,,,val
US05736540,CC(=O)C(O)(C(=O)Cl)c1ccccc1.Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1>>CC(=O)OC(C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20110190297A1,COc1ccc(B(O)O)cc1.NC(=O)C1CCN(c2c(Cl)cncc2Cl)CC1>>COc1ccc(-c2cncc(Cl)c2N2CCC(C(N)=O)CC2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20070232607A1,O=C(CCl)NCCN1CCOCC1.Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12>>O=C(COc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)NCCN1CCOCC1,,CC(=O)N(C)C,,[I-].[K+],,val
US20130102576A1,CCOC(=O)CBr.O=[N+]([O-])c1c[nH]c2ccccc12>>CCOC(=O)Cn1cc([N+](=O)[O-])c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20040102433A1,C=CCOC(=O)N1CC=C(C(=O)OC)[C@H]1CO.ClC(Cl)(Cl)Cl>>C=CCOC(=O)N1CC=C(C(=O)OC)[C@H]1CCl,,ClC(Cl)Cl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100261698A1,COC=Cc1cncc(-c2cc3ccccc3n2C)c1>>COCCc1cncc(-c2cc3ccccc3n2C)c1,[Pd],CO,,,,val
US20060030613A1,CCN(CCNCc1ccc(C(C)(C)C)cc1)c1cccc(C)c1.O=C(O)c1cc(Cl)cc2cc[nH]c12>>CCN(CCN(Cc1ccc(C(C)(C)C)cc1)C(=O)c1cc(Cl)cc2cc[nH]c12)c1cccc(C)c1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20100113512A1,FC(F)(F)c1cc(I)ccc1C1OCCO1.NC(=O)c1cccc(B(O)O)c1>>NC(=O)c1cccc(-c2ccc(C3OCCO3)c(C(F)(F)F)c2)c1,,CCO,Cc1ccccc1,,,val
US20140228361A1,COCN(Cc1ccccc1)C[Si](C)(C)C.O=C1C=CCCO1>>O=C1OCCC2CN(Cc3ccccc3)CC12,,ClCCl,,O=C(O)C(F)(F)F,,val
US05837718,CCBr.N=C(S)Nc1ccccc1>>CCSC(=N)Nc1ccccc1,,CCO,,CCOC(C)=O,,val
US05438052,Cc1cc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)C(=O)c4csc(N)n4)[C@H]3SC2)n2nc(C(=O)NO)nc2n1.NOCc1nc(=O)c(O)c[nH]1>>Cc1cc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)/C(=N\OCc4nc(=O)c(O)c[nH]4)c4csc(N)n4)[C@H]3SC2)n2nc(C(=O)NO)nc2n1,,CC(=O)N(C)C,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20080027115A1,C=CCCCCCCCCC(=O)O.O=C(Cl)C(=O)Cl>>C=CCCCCCCCCC(=O)Cl,,ClCCl,,,,val
US05459270,CC(=O)OC=O.FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1>>O=CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1,,C1CCOC1,,,,val
US05171865,COC(=O)c1cc(=O)c2cc(F)ccc2o1.C[C@@H](N)c1ccccc1>>C[C@@H](NC(=O)c1cc(=O)c2cc(F)ccc2o1)c1ccccc1,,c1ccccc1,,C[O-].[Na+],,val
US20110183985A1,COCCN1CCN(c2c(C(=O)N(C)OC)cc(Cl)c3cccnc23)CC1.C[Mg]Br>>COCCN1CCN(c2c(C(C)=O)cc(Cl)c3cccnc23)CC1,,C1CCOC1,,,,val
US20130296290A1,CCOC(=O)CN(C(=O)OC(C)(C)C)C1CN(C(=O)OC(C)(C)C)C1.NN>>CC(C)(C)OC(=O)N1CC(N(CC(=O)NN)C(=O)OC(C)(C)C)C1,,CCO,,,,val
US20120202845A1,CCCCO/N=[N+](\[O-])N1CCC[C@H]1C(=O)O.Cc1ncc2c(c1O)CO[C@H]2c1ccc(Cl)cc1>>CCCCO/N=[N+](\[O-])N1CCC[C@H]1C(=O)Oc1c(C)ncc2c1CO[C@H]2c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,O=C1OCCN1P(=O)(Cl)N1CCOC1=O,val
US03936471,CCN[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(C)cc1.O=C(O)c1ccccc1C(=O)c1ccccc1>>CCN(C(=O)c1ccccc1C(=O)c1ccccc1)[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(C)cc1,,CCN(CC)CC,,ClCCl,,val
US20100105921A1,CC(C=O)c1ccccc1.O=Nc1ccccc1>>CC(C(=O)N(O)c1ccccc1)c1ccccc1,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US20070185058A1,C#Cc1cccc(CCN(Cc2ccc(C(C)(C)C)cc2)C(=O)OC(C)(C)C)c1>>CCc1cccc(CCN(Cc2ccc(C(C)(C)C)cc2)C(=O)OC(C)(C)C)c1,[Pd],CO,,,,val
US20140057937A1,CCOC(=O)CBr.Cc1[nH]nc(C(F)(F)F)c1Cl>>Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)O,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04410520,CC(C(=O)O)N1C(=O)C(N)CCc2ccccc21.CCOC(=O)C(=O)CCc1ccccc1.Cl>>CCOC(=O)C(CCc1ccccc1)NC1CCc2ccccc2N(C(C)C(=O)O)C1=O.Cl,,CC(=O)O,CO,Cl,[BH3-]C#N.[Na+],val
US20090291971A1,Brc1cnc(On2nnc3cccnc32)nc1.COOB(O)c1cccnc1>>COc1ncccc1Oc1ncc(Br)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150210720A1,CC(=O)N1CCN(c2ccc([N+](=O)[O-])c(OC3CSC3)n2)CC1.O=C(OO)c1cccc(Cl)c1>>CC(=O)N1CCN(c2ccc([N+](=O)[O-])c(OC3CS(=O)C3)n2)CC1,,ClCCl,,,,val
US20160016927A1,O=[N+]([O-])c1cccc(-c2ccc3c(c2)CC(c2cc(Cl)cc(Cl)c2)(C(F)(F)F)O3)c1F>>Nc1cccc(-c2ccc3c(c2)CC(c2cc(Cl)cc(Cl)c2)(C(F)(F)F)O3)c1F,[Ni],CO,O,[H][H],,val
US20040259923A1,CC(=O)Nc1nc(CCc2ccc(NC(=O)OC(C)(C)C)cc2)c(Cc2ccc(S(C)(=O)=O)cc2)s1>>CC(C)(C)OC(=O)Nc1ccc(CCc2nc(N)sc2Cc2ccc(S(C)(=O)=O)cc2)cc1,,CCO,,[Na+].[OH-],,val
US20060241127A1,Nc1nc(Cl)cc(Nc2ccc(Oc3ccc4[nH]ncc4c3)c(F)c2)n1>>Nc1nccc(Nc2ccc(Oc3ccc4[nH]ncc4c3)c(F)c2)n1,[Pd],CCO,,,,val
US20090280106A1,CCOC(=O)c1scnc1S>>O=C(O)c1scnc1S,,CO,O,[Na+].[OH-],,val
US20030114668A1,Br.Br.COc1cc(CC2CNCCN2)ccc1C>>Br.Br.Cc1ccc(CC2CNCCN2)cc1O,,Br,,,,val
US20120225812A1,CCCn1c(Cl)nc2nc(C3CCCC3)[nH]c2c1=O.Nc1ccccc1>>CCCn1c(Nc2ccccc2)nc2nc(C3CCCC3)[nH]c2c1=O,,CN1CCCC1=O,,O,,val
US04777176,C=O.CC(C)(C)c1ccc2c(c1)CCCC2=O.CC1=C(CN2CCCCC2)CCc2cc(C(C)(C)C)ccc21>>CC(C)(C)c1ccc2c(c1)CCC(CN1CCCCC1)C2=O,Cl,CCO,,C1CCNCC1,,val
US20120323005A1,CC(C)(C)OC(=O)C[C@H]1C[C@@H](CO)OC(C)(C)O1>>CC1(C)O[C@H](CO)C[C@H](CC(=O)O)O1,,C1CCOC1,,[Na+].[OH-],,val
US20110190281A1,CCS(=O)(=O)Cl.COc1c(OCCCN)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21>>CCS(=O)(=O)NCCCOc1ccc2c(c1OC)N=C(NC(=O)c1cccnc1)N1CCN=C21,,CN(C)C=O,ClCCl,CCN(CC)CC,,val
US20060089394A1,CCCCC(O)c1ccc(-c2ccc(Cl)cc2)cc1.CCOC(=O)COc1ccc(O)cc1C>>CCCCC(Oc1ccc(OCC(=O)OCC)c(C)c1)c1ccc(-c2ccc(Cl)cc2)cc1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20040063658A1,CO.Nc1ncnc2c1nc(Br)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O>>COc1nc2c(N)ncnc2n1C1OC(CO)C(O)C1O,,CO,,C[O-].[Na+],,val
US05804588,CC(C)(C)[Si](C)(C)Cl.Cc1ccc2cccc(O)c2n1>>Cc1ccc2cccc(O[Si](C)(C)C(C)(C)C)c2n1,,CN(C)C=O,O,c1c[nH]cn1,,val
US20040176433A1,CN(C)/C=C(\C(=O)c1cccc(Cl)c1)c1ccnc(Br)c1.NN>>Clc1cccc(-c2n[nH]cc2-c2ccnc(Br)c2)c1,,CCO,,O,,val
US20070197577A1,CC(C)(C)OC(=O)N[C@H](C(=O)OCc1ccccc1)c1ccc(O)cc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N[C@H](C(=O)OCc1ccccc1)c1ccc(OS(=O)(=O)C(F)(F)F)cc1,,ClCCl,,c1ccncc1,,val
US20090215843A1,C=CCOC(=O)C(CCCCC(=O)OCC)C(=O)OCC=C.N#Cc1ccc(CCBr)cc1>>C=CCOC(=O)C(CCCCC(=O)OCC)(CCc1ccc(C#N)cc1)C(=O)OCC=C,,CN(C)C=O,,O,[H-].[Na+],val
US20030073668A1,CO.CSc1ncc2ccc(N)nc2n1>>CS(=O)c1ncc2ccc(N)nc2n1,,ClCCl,,,,val
US05334794,C=CC=C.Cc1ccccc1>>CCC=CCc1ccccc1,,CC(C)O,,,,val
US04281003,Nc1ccc(Cl)cn1.O=C=NC(=O)c1c(F)cccc1Cl>>O=C(NC(=O)c1c(F)cccc1Cl)Nc1ccc(Cl)cn1,,CC#N,,,,val
US20130079324A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)[C@@H]1CN(Cc2ccccc2)C[C@H]1C(F)(F)F>>CCOC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1C(F)(F)F,[Pd],CCO,,[H][H],,val
US04182893,Nc1ccc(SC=CC(Cl)Cl)cc1[N+](=O)[O-]>>Nc1ccc(SCC=C(Cl)Cl)cc1N,,CO,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20100168094A1,BrCc1ccccc1.Oc1ccc(Br)cc1C1CCCC1>>Brc1ccc(OCc2ccccc2)c(C2CCCC2)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090209607A1,COC(=O)c1cc(-c2ccnn2C)c(C)o1.O=C1CCC(=O)N1Br>>Cc1oc(C(=O)O)cc1-c1c(Br)cnn1C,,C1CCOC1,,[Na+].[OH-],,val
US05358939,N#CC(CCc1ccc(Cl)cc1)(Cn1cncn1)c1ccccc1>>NCC(CCc1ccc(Cl)cc1)Cn1cncn1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160158207A1,CNC(=O)n1ccnc1.Cc1c(-c2cc3c(cc2C(F)F)N(c2nn(C4CCS(=O)(=O)CC4)c4c2CNCC4)CCC3)cnn1C>>CNC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5C)c(C(F)F)cc43)nn2C2CCS(=O)(=O)CC2)C1,,ClCCl,,CCN(CC)CC,O,val
US04061761,CN=C1SCC(O)(c2ccc(Cl)c(S(=O)(=O)Cl)c2)N1C.NCc1ccccn1>>CN=C1SCC(O)(c2ccc(Cl)c(S(=O)(=O)NCc3ccccn3)c2)N1C,,CCN(CC)CC,,Br,,val
US20130303533A1,CC(C)(C)NN.O=Cc1c(Cl)nc(Cl)nc1Cl>>CC(C)(C)n1ncc2c(Cl)nc(Cl)nc21,,CCO,,Cl,,val
US05521213,COC(=O)c1sc(-c2ccc(F)cc2)c(-c2ccc(SC)cc2)c1CBr.O>>CSc1ccc(-c2c(-c3ccc(F)cc3)sc(C(=O)O)c2CO)cc1,,CN(C)C=O,,,,val
US20110092490A1,Cc1ccc(N)cc1S(=O)(=O)N1CCOCC1.N#CN>>Cc1ccc(NC(=N)N)cc1S(=O)(=O)N1CCOCC1,,CCO,,Cl,,val
US20150166564A1,CC(C)(C)OC(=O)N[C@@H]1CN([C@@H](CO)C(F)(F)F)C[C@H]1c1ccc(F)c(F)c1.CI>>COC[C@H](N1C[C@@H](NC(=O)OC(C)(C)C)[C@H](c2ccc(F)c(F)c2)C1)C(F)(F)F,,Cc1ccccc1,,CC#N,,val
US06110960,CC(=O)Cl.CC(C)(C)c1cccc2c1OCCC2>>CC(=O)c1cc2c(c(C(C)(C)C)c1)OCCC2,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US04385058,CN(C)Cc1ccnc(CSCCN)c1.Cc1ccc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)cn1>>Cc1ccc(Cc2cnc(NCCSCc3cc(CN(C)C)ccn3)[nH]c2=O)cn1,,c1ccncc1,,,,val
US20050020652A1,CCOC(=O)C(C)(C)Oc1ccc(OCCC2CN(Cc3ccc(C)c(C)c3)C(=O)N2)cc1.CI>>CCOC(=O)C(C)(C)Oc1ccc(OCCC2CN(Cc3ccc(C)c(C)c3)C(=O)N2C)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100239526A1,COc1ccc(Cn2ncc3c4c(cnc32)CN(C(=O)[C@@H](NC(=O)OC(C)(C)C)c2ccccc2)CC4)cc1.COc1ccc(Cn2ncc3c4c(cnc32)CN(C(=O)[C@@H]([NH3+])c2ccccc2)CC4)cc1.O=C(O)C(F)(F)F.O=C([O-])C(F)(F)F>>COc1ccc(Cn2ncc3c4c(cnc32)CN(C(=O)[C@@H]([NH3+])c2ccccc2)CC4)cc1.O=C([O-])C(F)(F)F.O=C([O-])C(F)(F)F.[NH3+][C@H](C(=O)N1CCc2c(cnc3[nH]ncc23)C1)c1ccccc1,,ClCCl,,,,val
US20090281152A1,Cc1ccc2[nH]ccc2c1.O=C(Cl)C(Cl)(Cl)Cl>>Cc1ccc2[nH]cc(C(=O)C(Cl)(Cl)Cl)c2c1,,C1COCCO1,CCOC(C)=O,c1ccncc1,,val
US20100048568A1,Cc1nc(-c2ccccn2)ncc1C(=O)Cl.Nn1ccc2cc(F)ccc21>>Cc1nc(-c2ccccn2)ncc1C(=O)Nn1ccc2cc(F)ccc21,,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120263670A1,CN(CCCN)CCCN.CN1Cc2c(Cl)cc(Cl)cc2C(c2cccc(S(=O)(=O)Cl)c2)C1>>CN(CCCN)CCCNS(=O)(=O)c1cccc(C2CN(C)Cc3c(Cl)cc(Cl)cc32)c1,,ClCCl,,CCN(CC)CC,,val
US20150266881A1,Cl.Cl.Cn1cc(NC(=O)c2cc([C@@H]3C[C@H]3N)ccc2F)cn1.O=C1CCC(F)(F)CC1>>Cl.Cl.Cn1cc(NC(=O)c2cc([C@@H]3C[C@H]3NC3CCC(F)(F)CC3)ccc2F)cn1,,CC(=O)O,CO,O=C([O-])O.[Na+],,val
US05700809,CC(=O)N1CCC(=O)CC1.COc1ccc(Br)cc1>>COc1ccc(C2(O)CCN(C(C)=O)CC2)cc1,,C1CCOC1,,Cl,[Mg],val
US20110076292A1,CC(C)NN.CSC(=N)NC(=O)c1cn2c(n1)-c1ccc(Br)cc1OCC2>>CSc1nc(-c2cn3c(n2)-c2ccc(Br)cc2OCC3)n(C(C)C)n1,,CC(=O)O,,Cl,,val
US20100004459A1,CCOC(=O)c1cccnc1-c1cccc(C#N)c1O.COCOc1c(C(C)(C)C)cc(CCCCOS(C)(=O)=O)cc1C(C)(C)C>>CCOC(=O)c1cccnc1-c1ccc(OCCCCc2cc(C(C)(C)C)c(OCOC)c(C(C)(C)C)c2)c(C#N)c1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20030092712A1,COc1ccc(CN2Cc3c(-c4ccccc4Cl)cc(N)cc3N(c3c(Cl)cccc3Cl)C2=O)cc1.Cn1cnc(S(=O)(=O)Cl)c1>>COc1ccc(CN2Cc3c(-c4ccccc4Cl)cc(NS(=O)(=O)c4cn(C)cn4)cc3N(c3c(Cl)cccc3Cl)C2=O)cc1,CN(C)c1ccncc1,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20110237588A1,CC(C)Cn1cc(-c2ccnc(Cl)c2)c(-c2ccc(Cl)s2)n1.Clc1cc(-c2c[nH]nc2-c2ccc(Cl)s2)ccn1>>CC(C)Cn1ncc(-c2ccnc(Cl)c2)c1-c1ccc(Cl)s1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130317057A1,CNc1cc(C#N)c(Br)cc1[N+](=O)[O-]>>CNc1cc(C#N)c(Br)cc1N,[Pd],CCO,,,,val
US20150266867A1,Cc1nnnn1C[C@H]1NC(=O)[C@H]1NC(=O)OCc1ccccc1>>Cc1nnnn1C[C@H]1NC(=O)[C@H]1N,[Pd],CCO,CO,,,val
US20160083387A1,CC(=O)O[C@H]1[C@@H]2CCC3(OCCO3)[C@@]2(C)CC[C@@H]1[C@@]1(C)CC[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1CCN1CCCC1>>CC(=O)O[C@H]1[C@@H]2CCC(=O)[C@@]2(C)CC[C@@H]1[C@@]1(C)CC[C@H](O)C[C@@H]1CCN1CCCC1,,CC(=O)O,,O,,val
US20030073710A1,Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1.ClC(c1ccccc1)c1ccccc1>>Cc1cc(C)nc(NS(=O)(=O)c2ccc(NC(c3ccccc3)c3ccccc3)cc2)n1,,c1ccncc1,,,,val
US20110021522A1,COc1ccc(-c2cccc(N)c2)cc1OC.O=C(O)c1cc2cccc(OC(F)(F)F)c2oc1=O>>COc1ccc(-c2cccc(NC(=O)c3cc4cccc(OC(F)(F)F)c4oc3=O)c2)cc1OC,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070197619A1,CCN=C=NCCCN(C)C.CN(Cc1nc(CC(=O)O)cn1-c1ccc(Cl)cc1)c1ccc(F)cc1.Nc1ccccc1N>>CCN(Cc1nc(CC(=O)Nc2ccccc2N)cn1-c1ccc(Cl)cc1)c1ccc(F)cc1,,c1ccncc1,,Cl,,val
US20140357614A1,CN1CCNCC1.Clc1cnnc(Cl)c1>>CN1CCN(c2cnnc(Cl)c2)CC1,,C1CCOC1,CCOC(C)=O,,,val
US07888487B2,BrBr.COc1ccc(-c2cc(OCc3ccccc3)nn2C(C)C)cc1>>COc1ccc(-c2c(Br)c(OCc3ccccc3)nn2C(C)C)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US06696473B2,CCNc1ccc(C(C)=O)cc1N=C1SC(=C2Sc3ccccc3N2CC)C(=O)N1Cc1ccccc1>>CCNc1ccc(C(C)O)cc1N=C1SC(=C2Sc3ccccc3N2C)C(=O)N1Cc1ccccc1,,C1CCOC1,CO,[BH4-].[Na+],,val
US05872111,CCCCCCCCCCCCCCCCN.O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>CCCCCCCCCCCCCCCCNC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O,,O,,CC(C)O,,val
US20140323300A1,Cc1c(NN)ccc(S(C)(=O)=O)c1C1=NOCC1.O=C1OC(O)C(Br)=C1Br>>Cc1c(-n2ncc(Br)c(Br)c2=O)ccc(S(C)(=O)=O)c1C1=NOCC1,,Br,,,,val
US20100041635A1,CC(C)(C)OC(=O)Nc1cccc(-c2ccc(/C=C3/C(=O)Nc4ccccc43)o2)c1>>Nc1cccc(-c2ccc(/C=C3/C(=O)Nc4ccccc43)o2)c1,,C1COCCO1,Cl,,,val
US20130216498A1,COC(=O)[C@@H]1CCCN1.Fc1ccc2ncc(-c3nccc(Cl)n3)n2c1>>COC(=O)[C@@H]1CCCN1c1ccnc(-c2cnc3ccc(F)cn23)n1,,CO,,CCN(CC)CC,Cl,val
US20080146616A1,CC1(C)OB(c2cccnc2)OC1(C)C.CCOC(=O)c1[nH]c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1I>>CCOC(=O)c1[nH]c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1-c1cccnc1,,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US20030176506A1,CCO.O=C(O)c1ccc(Br)c(O)c1>>CCOC(=O)c1ccc(Br)c(O)c1,,c1ccccc1,,CS(=O)(=O)O,,val
US20070191362A1,C1CCNCC1.O=C1CCCC1>>C1=C(N2CCCCC2)CCC1,,c1ccccc1,,,,val
US20140121200A1,CCI.CS(=O)(=O)N1CCO[C@H](CNc2nc(-c3ccc(C4CCNCC4)cc3)cc3nccnc23)C1>>CCN1CCC(c2ccc(-c3cc4nccnc4c(NC[C@@H]4CN(S(C)(=O)=O)CCO4)n3)cc2)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20080300239A1,Brc1cnc2nn[nH]c2c1.C[Sn](C)(C)c1ccc2nccc(-c3ccncc3)c2c1>>c1cc(-c2ccnc3ccc(-c4cnc5nn[nH]c5c4)cc23)ccn1,,C1COCCO1,,,,val
US20100240717A1,CCc1cc(-c2noc(-c3cc(CC(C)C)c(C)s3)n2)cc(C)c1CCC(=O)O.NCCO>>CCc1cc(-c2noc(-c3cc(CC(C)C)c(C)s3)n2)cc(C)c1CCC(=O)NCCO,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120035409A1,CC1=C(C#N)C(c2ccc3[nH]nc(C)c3c2)C2=C(COC2=O)N1.CI>>CC1=C(C#N)C(c2ccc3[nH]nc(C)c3c2)C2=C(COC2=O)N1C,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20040266906A1,C=C(C)C(=O)NCCP(=O)(OCC)OCC>>C=CC(=O)NCCP(=O)(O)O,,ClCCl,,C[Si](C)(C)Br,,val
US20120220795A1,CCOC(=O)C(F)(F)Br.Ic1ccc(-c2ccccc2)cc1>>CCOC(=O)C(F)(F)c1ccc(-c2ccccc2)cc1,[Cu],CS(C)=O,,,,val
US06087380,CCCCCOC(=O)Cl.CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1OC)n2C)c1ccccn1>>CCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)c(OC)c1,,CCO,ClCCl,Cl,,val
US20140242300A1,O=C(NCc1ccccc1)Nc1ccccc1.O=C(O)CC(=O)O>>O=C1CC(=O)N(c2ccccc2)C(=O)N1Cc1ccccc1,,Cc1ccccc1,,CC(=O)OC(C)=O,,val
US20160237059A1,CCOC(=O)c1nocc1O.CI>>CCOC(=O)c1nocc1OC,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US05082950,CCOC(=O)C(OC(C)=O)(C(=O)OCC)c1ccc(C(=O)c2ccccc2)[nH]1>>CCOC(=O)C(C(=O)OCC)c1ccc(C(=O)c2ccccc2)[nH]1,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US06566381B1,COC(=O)C(CC1CO1)NS(=O)(=O)c1ccc(-c2ccc(OC)cc2)cc1.SCc1ccccc1>>COc1ccc(-c2ccc(S(=O)(=O)NC3CC(CSCc4ccccc4)OC3=O)cc2)cc1,,O,c1ccccc1,CCN(CC)CC,O=C([O-])O.[Na+],val
US20040254161A1,N#CCc1ccc(Oc2ccc3c(c2)S(=O)(=O)NC2CCCN32)cc1.NO>>NC(Cc1ccc(Oc2ccc3c(c2)S(=O)(=O)N=C2CCCN23)cc1)=NO,,CS(C)=O,,CCN(CC)CC,Cl,val
US20110294777A1,C=CCOC(=O)[C@@H]1C[C@@H](NOCc2ccccc2)CN1C(=O)OC(C)(C)C.O=C(Cl)OC(Cl)(Cl)Cl>>C=CCOC(=O)[C@@H]1C[C@@H](N(OCc2ccccc2)C(=O)OC(Cl)(Cl)Cl)CN1C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US20160207930A1,Cc1nn(Cc2ccccc2)cc1C(=O)[C@@H]1CCC(=O)N1CCNC(=O)OC(C)(C)C>>Cc1nn(Cc2ccccc2)cc1[C@@H](O)[C@@H]1CCCN1CCNC(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20090220438A1,COc1c(C)oc2cc(O)cc(O)c2c1=O>>Cc1oc2cc(O)cc(O)c2c(=O)c1O,,ClCCl,,BrB(Br)Br,,val
US20080312226A1,CCC(=O)Nc1ccc(NC(=O)OCC(Cl)(Cl)Cl)cc1.Fc1ccccc1-c1nsc(N2CCNCC2)n1>>CCC(=O)Nc1ccc(NC(=O)N2CCN(c3nc(-c4ccccc4F)ns3)CC2)cc1,,O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20120142659A1,CI.Cc1ccc(C(=O)N[C@H](CN2CCC(F)(F)C2)C(C)C)cc1C>>Cc1ccc(C(=O)N(C)[C@H](CN2CCC(F)(F)C2)C(C)C)cc1C,,C1CCOC1,,[H-].[Na+],,val
US20070167476A1,CC(C)(C)OC(=O)NCCN.O=[N+]([O-])c1cnc2cc(OCc3ccccc3)ccc2c1Cl>>CC(C)(C)OC(=O)NCCNc1c([N+](=O)[O-])cnc2cc(OCc3ccccc3)ccc12,,CN(C)C=O,,CCN(CC)CC,O,val
US20110160433A1,CCCCCCCCCCCCCCCCCCOC1CC(CO)CC(OCCCCCCCCCCCCCCCCCC)C1OCCCCCCCCCCCCCCCCCC.COc1cc(O)ccc1C=O>>CCCCCCCCCCCCCCCCCCOC1CC(COc2ccc(C=O)c(OC)c2)CC(OCCCCCCCCCCCCCCCCCC)C1OCCCCCCCCCCCCCCCCCC,,C1CCOC1,O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06235911B1,CCOC(=O)CC#N.O=C(Cl)C(F)(F)C(F)(F)F>>CCOC(=O)C(C#N)=C(O)C(F)(F)C(F)(F)F,,C1CCOC1,,CCN(CC)CC,,val
US20080171771A1,CC(C)(C)S(=O)N=C(c1cccc(Br)c1)c1ccccc1C#N.COc1ccc(Br)cc1>>COc1ccc(C2(c3cccc(Br)c3)N=C(N)c3ccccc32)cc1,,C1CCOC1,,[Li]CCCC,,val
US20100160304A1,CC1(C)OC(=O)Nc2ccc(Br)cc21.CN(C)C=O>>CC1(C)OC(=O)Nc2ccc(C=O)cc21,,O,,C1CCOC1,,val
US04273709,C[C@@H](O)[C@H]1C(=O)N[C@@H]1CC(=O)CC(=O)OCc1ccc([N+](=O)[O-])cc1.[N-]=[N+]=NS(=O)(=O)c1ccc(C(=O)O)cc1>>[N-]=[N+]=C(C(=O)CC1CC(=O)N1)C(=O)OCc1ccc([N+](=O)[O-])cc1,,CC#N,,CCN(CC)CC,,val
US20050049261A1,CS(=O)(=O)OCCCc1ccccc1F.O=c1cc(-c2ccncc2)nc2n1CC(O)CN2>>O=c1cc(-c2ccncc2)nc2n1CC(O)CN2CCCc1ccccc1F,,CC#N,,[F-].[K+],,val
US20050233988A1,CN(C)C=O.Cc1ccc(C(=O)O)c(C)c1>>COC(=O)c1ccc(C)cc1C,CN(C)C=O,ClC(Cl)Cl,,O=C(Cl)C(=O)Cl,,val
US20130116234A1,CCOC(=O)c1c(C(C)C)nc2ccc(Cl)cc2c1Cc1ccccc1Cl>>CC(C)c1nc2ccc(Cl)cc2c(Cc2ccccc2Cl)c1C(=O)O,,CCO,,[Na+].[OH-],,val
US20080207654A1,CCCc1nc(C)n(-c2ccc(OC(C)C(N)=O)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCc1nc(C)n(-c2ccc(OC(C)C(N)=O)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20150306095A1,CN1CCN(CC(=O)n2ccc3cc([N+](=O)[O-])ccc32)CC1>>CN1CCN(CC(=O)n2ccc3cc(N)ccc32)CC1,[Pd],CO,,,,val
US20110003787A1,COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(C(=O)NNC(C)=O)[nH]2)c1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(-c3nnc(C)s3)[nH]2)c1,,CCOC(C)=O,Cc1ccccc1,O,c1ccncc1,val
US20100278833A1,COC(=O)c1sc(-n2cnc3cnc(CO[Si](C)(C)C(C)(C)C)cc32)cc1O.OC(c1ccccc1Cl)C(F)(F)F>>COC(=O)c1sc(-n2cnc3cnc(CO[Si](C)(C)C(C)(C)C)cc32)cc1OC(c1ccccc1Cl)C(F)(F)F,,ClCCl,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040254205A1,COc1cc2ncnc3c2c(c1OC)CC(CI)N3c1ccc(F)c(Cl)c1>>COc1cc2ncnc3c2c(c1OC)C=C(C)N3c1ccc(F)c(Cl)c1,,Cc1ccccc1,ClC(Cl)Cl,C1CCC2=NCCCN2CC1,,val
US20130116443A1,CCOC(=O)CC(=O)OCC.COc1cc([N+](=O)[O-])ccc1-n1cccc(Br)c1=O>>CCOC(=O)C(C(=O)OCC)c1cccn(-c2ccc([N+](=O)[O-])cc2OC)c1=O,,C1COCCO1,,,,val
US20080139610A1,COc1ccc2c(c1)CCNC2.Cc1cc(Br)cc(C)c1NC(=O)CC(C)(C)C>>COc1ccc2c(c1)CCN(c1cc(C)c(NC(=O)CC(C)(C)C)c(C)c1)C2,,Cc1ccccc1,,Cl,CC(C)(C)[O-].[K+],val
US20100216788A1,CC(C)(C)c1coc(-c2cccc(Oc3ccc([N+](=O)[O-])cc3Cl)c2)n1>>CC(C)(C)c1coc(-c2cccc(Oc3ccc(N)cc3Cl)c2)n1,[Pt],CO,,CCOC(C)=O,,val
US20140171404A1,CC(C)(C)OC(=O)N1CCC(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)CC1.O=CCCCc1cn(Cc2ccccc2)nn1>>CC(C)(C)OC(=O)N1CCC(/C=C/CCCc2cn(Cc3ccccc3)nn2)CC1,,C1CCOC1,,[Li]CCCC,,val
US20100120862A1,CC(=O)c1cnc(Cl)c(Cl)c1>>CC(O)c1cnc(Cl)c(Cl)c1,,CO,,[BH4-].[Na+],,val
US20160002225A1,Clc1ccnc2[nH]ncc12.II>>Clc1ccnc2[nH]nc(I)c12,,CN(C)C=O,,[K+].[OH-],,val
US20090275567A1,BrCCc1ccccc1.Cc1ncc(-c2ccnc(NC3CCNCC3)n2)n1C(C)C>>Cc1ncc(-c2ccnc(NC3CCN(CCc4ccccc4)CC3)n2)n1C(C)C,,CN(C)C=O,,,,val
US20120015942A1,COc1ccc(CCCC(=O)O)cc1F>>COc1cc2c(cc1F)CCCC2=O,,O=C(O)C(F)(F)F,,CS(=O)(=O)O,,val
US20010053779A1,O=[N+]([O-])c1ccc(Cl)cc1[N+](=O)[O-].OCCCCc1ccccc1>>O=[N+]([O-])c1ccc(OCCCCc2ccccc2)cc1[N+](=O)[O-],,C1CCOC1,,[H-].[Na+],,val
US20090264650A1,O=C1N(Cc2ccc(Cl)cc2Cl)CCN1C1CCC2(CC1)OCCO2>>O=C1CCC(N2CCN(Cc3ccc(Cl)cc3Cl)C2=O)CC1,,C1CCOC1,,Cl,O=C([O-])O.[Na+],val
US20110136764A1,CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(Br)c4c3C(=O)N(C)C4)n2)c(OC)c1)OCC.O=C(O)c1ccc(B(O)O)cc1>>CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(-c4ccc(C(=O)O)cc4)c4c3C(=O)N(C)C4)n2)c(OC)c1)OCC,,C1COCCO1,O,ClCCl,O=C([O-])[O-].[K+].[K+],val
US04935413,C=C(C)C(=O)N=C=O.O=C(c1ccccc1)C(O)c1ccccc1>>C=C(C)C(=O)NC(=O)OC(C(=O)c1ccccc1)c1ccccc1,,ClCCCl,,ClC(Cl)Cl,,val
US20080045556A1,CC1(C)COC(=O)N1c1nc(-c2ccc(Br)cc2F)cs1.N#C[Cu]>>CC1(C)COC(=O)N1c1nc(-c2ccc(C#N)cc2F)cs1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(=O)N(C)C,,c1ccncc1,,val
US20140288123A1,CC(O)c1ccc(Br)c(F)c1.Oc1ccccc1>>CC(Oc1ccccc1)c1ccc(Br)c(F)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070149437A1,CN(C)CCCN.O=S(=O)(Cl)CCCC(F)(C(F)(F)F)C(F)(F)F>>CN(C)CCCNS(=O)(=O)CCCC(F)(C(F)(F)F)C(F)(F)F,,ClC(Cl)Cl,,,,val
US20120029226A1,C[C@@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c1.NCc1ccccc1>>C[C@@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c1.NCc1ccccc1,,CCO,,,,val
US20080269268A1,BrBr.C[Si](C)(C)CCOCn1ccc2c([N+](=O)[O-])ccnc21>>C[Si](C)(C)CCOCn1cc(Br)c2c([N+](=O)[O-])ccnc21,,ClCCl,,,,val
US04647558,CS(=O)C1(NC(=O)COc2ccccc2)CNC1=O.N>>NC1(NC(=O)COc2ccccc2)CNC1=O,,C1CCOC1,,,,val
US20150361067A1,COC(=O)C(c1cc(Cl)c2c(c1Cl)C(=O)N(Cc1c(C)cc(C)[nH]c1=O)CC2)N1CC[C@@H](F)C1>>Cc1cc(C)c(CN2CCc3c(Cl)cc(C(CO)N4CC[C@@H](F)C4)c(Cl)c3C2=O)c(=O)[nH]1,CO,C1CCOC1,,[BH4-].[Li+],,val
US20090042854A1,C[C@@H](O[C@H]1CN2C(=O)C(N=[N+]=[N-])C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,[Pd],C1COCCO1,CCO,Cl,,val
US20150011533A1,CC(C)(C)OC(=O)N[C@@H]1CCCNC1.O=C(Nc1c[nH]c2ncc(Br)c(F)c12)c1cnn(Cc2ccccc2)c1>>N[C@@H]1CCCN(c2c(Br)cnc3[nH]cc(NC(=O)c4cnn(Cc5ccccc5)c4)c23)C1,,CCCCO,,,,val
US20050049272A1,CCOC(=O)c1cn2c(C)c(C)nc2c(O)c1CCC(=O)c1ccccc1>>CCOC(=O)c1cn2c(C)c(C)nc2c(O)c1CCC(O)c1ccccc1,,CCO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20120157430A1,Brc1ncnc2[nH]cnc12.COc1c(C(C)N)cc(Cl)c(C)c1N1CCCC1=O>>COc1c(C(C)Nc2ncnc3[nH]cnc23)cc(Cl)c(C)c1N1CCCC1=O,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20100075948A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.NC(=O)c1ccc(N)cc1>>CC(C)(C)CC1NC(C(=O)Nc2ccc(C(N)=O)cc2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05641788,CCCCC(=O)CC(C)=O.COc1ccc(C(=O)c2cc(OC)c(OC)cc2N)cc1OC>>CCCCC(=O)c1c(C)nc2cc(OC)c(OC)cc2c1-c1ccc(OC)c(OC)c1,,CCO,,Cl,,val
US20070123527A1,CNCCC(c1ccccc1)c1ccc2c(c1)c(S(C)(=O)=O)cn2S(C)(=O)=O>>CNCCC(c1ccccc1)c1ccc2[nH]cc(S(C)(=O)=O)c2c1,,CO,,[K+].[OH-],,val
US06013662,COc1ccccc1C1CCC(=O)CC1(O)C(=O)O>>COc1ccccc1C1CCC(=O)C=C1C(=O)O,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150218141A1,FC(F)(F)[C@@H]1CO1.FC(F)(F)c1cccc(C2CCCNC2)c1>>O[C@@H](CN1CCCC(c2cccc(C(F)(F)F)c2)C1)C(F)(F)F,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20080004261A1,NCCc1ccncc1.O=C(O)CC(S)C(=O)O.O=Cc1ccccc1>>O=C(O)CC1SC(c2ccccc2)N(Cc2ccncc2)C1=O,,O,,CN(C)C=O,,val
US20020173490A1,CCOP(=O)(OCC)c1ccc(C=O)o1.NO>>CCOP(=O)(OCC)c1ccc(C=NO)o1,,CCO,,CC(=O)[O-].[Na+],,val
US20100129753A1,CCCn1c2ccccc2c2cc(C(C)=O)ccc21.CCOC(C)=O>>CCCn1c2ccccc2c2cc(C(=O)CC(C)=O)ccc21,,O,,Cl,CC(C)(C)[O-].[K+],val
US04873236,NCCN1CCC(CCN2CCCCC2)CC1.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>Cl.O=C1Nc2cccnc2N(C(=O)NCCN2CCC(CCN3CCCCC3)CC2)c2ccccc21,,CC#N,,,,val
US06538152B1,CCOC(=O)CBr.COc1ccc(Cl)cc1O>>CCOC(=O)COc1cc(Cl)ccc1OC,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110319378A1,CC[C@@H]([C@H](C)O)N1C(=O)[C@@](C)(CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1.CI>>CC[C@@H]([C@H](C)O)N1C(=O)[C@@](C)(CC(=O)OC)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1,,C1CCOC1,,[H-].[Na+],,val
US04563452,CN1c2c(oc(=O)n(-c3ccccn3)c2=O)-c2ccccc2S1(=O)=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CN1c2c(oc(=S)n(-c3ccccn3)c2=O)-c2ccccc2S1(=O)=O,,Cc1ccccc1C,,,,val
US20080213510A1,CC(=O)OC(C)=O.CN1CCCC1=O.NC(CCCCCc1ccccc1)CCCCC1C(=O)NC(=O)C1N.Nc1ccccc1N.O=C1OC(=O)C2C1C1C(=O)OC(=O)C21.c1ccncc1>>CC1(C)CC(C)(c2ccc(N)cc2)c2ccc(N)cc21.O=C(c1ccc2c(c1)C(=O)OC2=O)c1ccc2c(c1)C(=O)OC2=O,,CN1CCCC1=O,,,,val
US20040204422A1,C=CCN1CCNCC1.CC(C)c1ccc(S(=O)(=O)Nc2cc(Cl)ncn2)cc1>>C=CCN1CCN(c2cc(NS(=O)(=O)c3ccc(C(C)C)cc3)ncn2)CC1,,CS(C)=O,O,,,val
US20100197683A1,CCOC(=O)C1CC(=O)C1.Cc1nnc(N)[nH]1>>CCOC(=O)C1CC(Nc2nnc(C)[nH]2)C1,,CC(=O)O,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100152168A1,COc1ccc(S(=O)(=O)n2c(=O)n(CC(=O)OC(C)(C)C)c3cc(Cl)ccc32)cc1>>COc1ccc(S(=O)(=O)n2c(=O)n(CC(=O)O)c3cc(Cl)ccc32)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US03962053,CC(C)[N+](=O)[O-].CCOC(=O)C1([N+](=O)[O-])CCC1>>CCOC(=O)C1(C(C)(C)[N+](=O)[O-])CCC1,,CN(C)P(=O)(N(C)C)N(C)C,,[Li],,val
US20100010053A1,CCOC(=O)CCc1cc2cc(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)ccc2[nH]1.COC(=O)OC>>COC(=O)CCc1cc2cc(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)ccc2n1C,,CCOC(C)=O,CN(C)C=O,C1CN2CCN1CC2,,val
US04960781,CC(=O)C(C)(C)COS(C)(=O)=O.c1nc[nH]n1>>CC(=O)C(C)(C)Cn1cncn1,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US20070275962A1,CI.NC(=O)c1c(NC(=O)C2CC2)sc2cc(O)ccc12>>COc1ccc2c(C(N)=O)c(NC(=O)C3CC3)sc2c1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20090036492A1,CN(C)C=O.Cc1ccc2c(Br)c(C)ccc2c1>>Cc1ccc2c(C=O)c(C)ccc2c1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2cc(OC)ccc23)cc1.Nc1ccc2cn[nH]c2c1>>COc1ccc2c(c1)nc(Nc1ccc3cn[nH]c3c1)c1n[nH]cc12,C1COCCO1,CO,,Cl,,val
US20110124636A1,CC(C)(C)OC(=O)N1[C@H](C=O)C[C@@H]2C[C@@H]21.NCc1ccccc1>>CC(C)(C)OC(=O)N1[C@H](CNCc2ccccc2)C[C@@H]2C[C@@H]21,,ClCCl,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20090176778A1,CC(C)(C)OC(=O)Nc1nc2c(C(F)(F)F)cc(-c3ccco3)cn2c1Cl.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1nc2c(C(F)(F)F)cc(-c3ccco3)cn2c1Cl,,C1CCOC1,,[H-].[Na+],,val
US20140213586A1,CON(C)C(=O)c1noc2ccccc12.Cl[Mg]Cc1ccccc1>>O=C(Cc1ccccc1)c1noc2ccccc12,,C1CCOC1,,,,val
US04636523,FC(F)(Br)C(F)(F)Br.Sc1c(Cl)cccc1Cl>>FC(F)(Br)C(F)(F)Sc1c(Cl)cccc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2cc(F)c(O[C@H]3CC(F)(F)C[C@@H]3c3ccnn3C)cc2F)c(OC)c1>>Cn1nccc1[C@H]1CC(F)(F)C[C@@H]1Oc1cc(F)c(S(=O)(=O)Nc2ccncn2)cc1F,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20040072818A1,Clc1ccc2c(N3CCNCC3)ccnc2c1.N#CN=C(Oc1ccccc1)Oc1ccccc1.Nc1ccc(F)cc1>>N#CN=C(Nc1ccc(F)cc1)N1CCN(c2ccnc3cc(Cl)ccc23)CC1,,CC(C)O,,,,val
US20030199550A1,C1CCNCC1.CN(CC[C@@H]1CC[C@@H](/C=C/CCl)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1>>CN(CC[C@@H]1CC[C@@H](/C=C/CN2CCCCC2)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1,,CC(=O)N(C)C,,,,val
US06699861B1,C=O.CC(=O)OCc1nc2cc3c(cc2c(=O)n1COC(=O)C(C)(C)C)C(Nc1ccc(C(=O)OC(C)(C)C)cc1)CC3>>CC(=O)OCc1nc2cc3c(cc2c(=O)n1COC(=O)C(C)(C)C)C(N(C)c1ccc(C(=O)OC(C)(C)C)cc1)CC3,,C1CCOC1,,CC(=O)O,[BH3-]C#N.[Na+],val
US20090215786A1,CC(=O)Cl.N#Cc1nc2c(nc1C(N)=O)-c1ccccc1C2=NO>>CC(=O)ON=C1c2ccccc2-c2nc(C(N)=O)c(C#N)nc21,,c1ccncc1,,O,,val
US04948794,Nc1cc([N+](=O)[O-])ccc1NCc1ccccc1.O=C(O)C(=O)O>>O=c1[nH]c2cc([N+](=O)[O-])ccc2n(Cc2ccccc2)c1=O,,Cl,,O,O,val
US06048875,COc1ccc(Oc2c(C=O)sc3cc(OC)c(OC)cc23)cc1>>COc1ccc(Oc2c(CO)sc3cc(OC)c(OC)cc23)cc1,,CO,,[BH4-].[Na+],,val
US04940710,CCn1cc(C(=O)O)c(=O)c2cc(F)c(Cl)cc21.Cc1cc(C2CNCCN2)c(C)s1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(c4cc(C)sc4C)C3)cc21,,c1ccncc1,,,,val
US20050267172A1,N[C@@H](C[Se][Se]C[C@H](N)C(=O)O)C(=O)O.O=C(n1ccnc1)n1ccnc1>>O=C1N[C@H](C(=O)O)C[Se]1,,CCO,,[Na+].[OH-],,val
US20020037886A1,Cc1coc2ccccc12.ClCCCI>>Cc1c(CCCCl)oc2ccccc12,[Cu]I,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20090318689A1,CC1(C)CCC(=O)CC1.CN(C)C=O.O=P(Cl)(Cl)Cl>>CC1(C)CCC(Cl)=C(C=O)C1,,ClCCl,,,,val
US04238494,CCOC(CN)OCC.CSC(=C[N+](=O)[O-])S(C)=O>>CCOC(CNC(=C[N+](=O)[O-])SC)OCC,,CO,,,,val
US20150218096A1,CC(=O)N(C)c1ccc2c(-c3ccc(C(=O)[O-])cc3F)nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1>>CC(=O)N(C)c1ccc2c(-c3ccc(C(=O)O)cc3F)nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1,,C1CCOC1,O,[Li]O,,val
US20070149574A1,CC(C)(C)c1ccc(NC(=O)c2ccccc2S)cc1.CN(C)c1cc(CCl)ccn1>>CN(C)c1cc(CSc2ccccc2C(=O)Nc2ccc(C(C)(C)C)cc2)ccn1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20120142705A1,COC(=O)C(Br)CC(C)C.O=C1Nc2ccc(Cl)cc2C1=O>>COC(=O)C(CC(C)C)N1C(=O)C(=O)c2cc(Cl)ccc21,,CN(C)C=O,O,[H-].[Na+],,val
US06060469,CC(=O)OC(C)=O.COc1ccc(N)cc1Br>>COc1ccc(NC(C)=O)cc1Br,,ClCCl,,CO,,val
US04223136,CC(=O)OO.N#Cc1c2c(c[nH]c1=O)Sc1ccc(Cl)cc1N2>>N#Cc1c2c(c[nH]c1=O)S(=O)c1ccc(Cl)cc1N2,,CC(=O)O,,,,val
US05910506,CCOC(=O)CN.O=C(Cl)COCc1ccccc1>>CCOC(=O)CNC(=O)COCc1ccccc1,CN(C)c1ccncc1,ClCCl,,Cl,,val
US20120083475A1,CCOC(=O)c1sc(-c2ccc(C)cc2)nc1C>>Cc1ccc(-c2nc(C)c(C(=O)O)s2)cc1,,CCO,O,[Na+].[OH-],,val
US20080207608A1,Cc1ccc2cc(C(F)(F)F)ccc2n1.O=[Se]=O>>O=Cc1ccc2cc(C(F)(F)F)ccc2n1,,C1COCCO1,,,,val
US20120178715A1,N#Cc1ccc(Br)cc1F.O=C(O)C(F)(F)F>>NC(=O)c1ccc(Br)cc1F,,O,,O=S(=O)(O)O,,val
US04590196,COc1cccc2c1C=NS2=O.ClP(Cl)(Cl)(Cl)Cl>>COc1cccc2snc(Cl)c12,,CC(Cl)Cl,,,,val
US20100093757A1,CC(C)(C)[Si](C)(C)OC1CN(C[C@H](Oc2ncnc3c2cnn3-c2ncccc2Cl)C(=O)Nc2ccc(Cl)cn2)C1>>O=C(Nc1ccc(Cl)cn1)[C@H](CN1CC(O)C1)Oc1ncnc2c1cnn2-c1ncccc1Cl,,C1CCOC1,ClCCl,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20120196864A1,COc1cc(C=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F.N=C1CNC(=O)N1C(=O)c1ccccc1>>COc1cc(/C=C2\NC(=O)N(C(=O)c3ccccc3)C2=N)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,,CCO,,C1CCNCC1,,val
US20120034295A1,C#CCOCCOCCOS(=O)(=O)c1ccc(C)cc1.NC1CCCCC1>>C#CCOCCOCCNC1CCCCC1,,CCO,,,,val
US20080300242A1,O=[N+]([O-])c1ccc(F)cc1OCC(F)(F)F.OC1CCNCC1>>O=[N+]([O-])c1ccc(N2CCC(O)CC2)cc1OCC(F)(F)F,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05300514,O=C(Cl)Oc1ccc(Cl)cc1.O=C1NNC(c2ccccc2)C1c1ccccc1>>O=C1NN(C(=O)Oc2ccc(Cl)cc2)C(c2ccccc2)C1c1ccccc1,,ClC(Cl)Cl,,,,val
US20140288081A1,N#CBr.Nc1c(S)cccc1S(=O)(=O)Nc1ccc(C(=O)O)cc1>>Nc1nc2c(S(=O)(=O)Nc3ccc(C(=O)O)cc3)cccc2s1,,C1CCOC1,,,,val
US20110312944A1,C1CCNC1.CC(C)(C)c1cc(NC(=O)[C@@H]2CCCCN2C(=O)CCl)no1>>CC(C)(C)c1cc(NC(=O)[C@@H]2CCCCN2C(=O)CN2CCCC2)no1,CN(C)c1ccncc1,CN(C)C=O,,,,val
US20050131014A1,C[Mg]Br.O=C(c1ccccc1)c1cnc2c(C(F)(F)F)cccc2c1-c1ccccc1>>CC(O)(c1ccccc1)c1cnc2c(C(F)(F)F)cccc2c1-c1ccccc1,,C1CCOC1,,,,val
US05665723,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1NCCc2ccc(N3CCNCC3)cc21>>CC(C)(C)OC(=O)N1CCN(c2ccc3c(c2)C(=O)NCC3)CC1,,C1CCOC1,CCOCC,O,O=C([O-])[O-].[K+].[K+],val
US20090062223A1,CC1(O)C2O[Si](C(C)(C)C)(C(C)(C)C)OCC2OC1n1cc2c(N)cc3c(=O)[nH]ncc(n1)c23.Cc1oc(=O)oc1CO.O=C(O)Cl>>Cc1oc(=O)oc1COC(=O)Nc1cc2c(=O)[nH]ncc3nn(C4OC5CO[Si](C(C)(C)C)(C(C)(C)C)OC5C4(C)O)cc1c32,,c1ccncc1,,C[Si](C)(C)Cl,,val
US20060041146A1,CCC(=O)c1csc(NC(=O)[C@@H](NC(=O)[C@H](N)c2ccc(OCCN3CCOCC3)cc2)[C@@H](C)c2ccccc2)n1.O=C(Cl)OC(Cl)(Cl)Cl>>CCC(=O)c1csc(NC(=O)[C@H]([C@@H](C)c2ccccc2)N2C(=O)NC(c3ccc(OCCN4CCOCC4)cc3)C2=O)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20160102058A1,O=C(OC(C1CCCCC1)C1CCC(O)CC1)c1ccccc1>>O=C1CCC(C(OC(=O)c2ccccc2)C2CCCCC2)CC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05218124,CC(C(=O)N(C)O)c1ccc(-c2ccc(OCc3nc4ccccc4n3C)cc2)cc1.Cl>>CC(C(=O)N(C)O)c1ccc(-c2ccc(OCc3nc4ccccc4n3C)cc2)cc1.Cl,,CCOCC,CO,,,val
US20060089354A1,CC(C)(C)c1ccc(N)cc1OCCO[Si](C)(C)C(C)(C)C.OC1(Cl)NC=Nc2cc(-c3ncccc3C(F)(F)F)ccc21>>CC(C)(C)c1ccc(Nc2ncnc3cc(-c4ncccc4C(F)(F)F)ccc23)cc1OCCO[Si](C)(C)C(C)(C)C,,CC#N,,,,val
US20120228583A1,O=[N+]([O-])c1cccnc1Nc1cccc2c1oc1ccccc12>>Nc1cccnc1Nc1cccc2c1oc1ccccc12,[Pd],CCO,,,,val
US20140378447A1,Cn1ncc(-c2nc(C(F)F)c(Cl)s2)c1C(=O)O.Nc1ccn2cc(-c3ccccc3)nc2c1>>Cn1ncc(-c2nc(C(F)F)c(Cl)s2)c1C(=O)Nc1ccn2cc(-c3ccccc3)nc2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US04048141,CCCCP(CCCC)CCCC.O=C1C=CC(=O)O1>>CCCCP(CCCC)(CCCC)=C1CC(=O)OC1=O,,CC(C)=O,,,,val
US20030195259A1,Cc1ccc(C=O)cc1Br.OCCO>>Cc1ccc(C2OCCO2)cc1Br,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,O,,val
US20150291582A1,CI.Cc1cc(C(=O)O)cnc1OCC(F)F>>COC(=O)c1cnc(OCC(F)F)c(C)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04727077,Nc1ccc(Oc2ncc(Br)cn2)c(Cl)c1.O=C(Cl)Cl>>O=C=Nc1ccc(Oc2ncc(Br)cn2)c(Cl)c1,,CCOC(C)=O,,,,val
US20130129812A1,CCCCCCCCCC(=O)Cl.CCN(CC)CC.NCCc1c[nH]c2ccccc12>>CCCCCCCCCC([NH-])=O.NCCc1c[nH]c2ccccc12,,ClCCl,,Cl,,val
US20150299219A1,CC(C)(C)OC(=O)N(c1ccccc1)N1CCOCC1=O>>O=C1COCCN1Nc1ccccc1,,CCOC(C)=O,,Cl,[Na+].[OH-],val
US20060235029A1,CC(C)CN.CCN(CC)CCCNc1nc(-c2cccc(C(=O)O)c2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1>>CCN(CC)CCCNc1nc(-c2cccc(C(=O)NCC(C)C)c2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100048561A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(Br)c3cnc(Nc4ccc(N5CCOCC5)c(Cl)c4)nc23)CC1>>Clc1cc(Nc2ncc3c(Br)ccc(OC4CCNCC4)c3n2)ccc1N1CCOCC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20010029256A1,CCOC(=O)C(Cc1ccc(OCCN(C)C2c3ccccc3CCc3ccccc32)cc1)OCC>>CCOC(Cc1ccc(OCCN(C)C2c3ccccc3CCc3ccccc32)cc1)C(=O)O,,CCO,,[Na+].[OH-],,val
US20090181942A1,CNC.COc1cccc(C2OC(CCC(=O)N3CCC(CC(=O)O)CC3)c3cccn3-c3ccc(Cl)cc32)c1OC>>COc1cccc([C@H]2O[C@H](CCC(=O)N3CCC(CC(=O)N(C)C)CC3)c3cccn3-c3ccc(Cl)cc32)c1OC,,CO,,,,val
US05856503,C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(N)c1.NC=O>>C=CCN(C)CCCCCCOc1ccc2c(c1)N=CNC2c1ccc(Br)cc1,,O=CO,,,,val
US20030134808A1,CC(=O)OC[C@]1(COCc2ccccc2)O[C@@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)[C@H](OC(C)=O)[C@@H]1OCc1ccccc1>>O=C(Nc1ncnc2c1ncn2[C@@H]1O[C@](CO)(COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H]1O)c1ccccc1,,CO,,Cl,C[O-].[Na+],val
US20050215572A1,Clc1ncnc2c1CCN(Cc1ccccc1)C2.Nc1ccc(OC(F)F)cc1>>FC(F)Oc1ccc(Nc2ncnc3c2CCN(Cc2ccccc2)C3)cc1,,C1COCCO1,CCOCC,,,val
US05162360,CCCCCCCCCCCC(C)=O.C[Si](C)(C)Cl>>C=C(CCCCCCCCCCC)O[Si](C)(C)C,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US05872118,NC1CC1.O=C(Cl)/C=C1\CCc2c(F)cc(F)cc21>>O=C(/C=C1\CCc2c(F)cc(F)cc21)NC1CC1,,ClCCl,,,,val
US20080153812A1,COC(=O)c1cnc(C2=CCN(C)CC2)cn1.COc1cc(CCc2cc(N)[nH]n2)cc(OC)c1>>COc1cc(CCc2cc(NC(=O)c3cnc(C4=CCN(C)CC4)cn3)[nH]n2)cc(OC)c1,,Cc1ccccc1,,C[Al](C)C,,val
US20150111857A1,CC1(C)OCC(Cn2cc(N)cn2)O1.Clc1ncnc(N2CCN(c3ncc(Cc4ccccc4)cn3)CC2)n1>>CC1(C)OCC(Cn2cc(Nc3ncnc(N4CCN(c5ncc(Cc6ccccc6)cn5)CC4)n3)cn2)O1,,C1COCCO1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20020193402A1,FC(F)(F)c1cc(CO[C@@H]2CC[C@H]3CC[C@]2(c2ccccc2)N3Cc2ccccc2)cc(C(F)(F)F)c1>>FC(F)(F)c1cc(CO[C@@H]2CC[C@H]3CC[C@]2(c2ccccc2)N3)cc(C(F)(F)F)c1,[Pd],CCO,,,,val
US20040132727A1,CC(O)c1ccc(OC(F)(F)F)cc1.COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)OC(C)c4cccc(OC(F)(F)F)c4)cc3)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US20020082292A1,CCOC(=O)C1(CC)CCc2ccc(OCCCOCc3ccccc3)cc2O1>>CCOC(=O)C1(CC)CCc2ccc(OCCCO)cc2O1,[Pd],O,,CCO,,val
US05430042,CCOC(=O)c1ccc2[nH]c(S)nc2c1.COc1ccnc(CCl)c1OC>>CCOC(=O)c1ccc2[nH]c(SCc3nccc(OC)c3OC)nc2c1,,CCO,O,Cl,[Na+].[OH-],val
US20070155727A1,C1CCOC1.CC(C)(C)OC(=O)N1CCNC(=O)CC1.O=C([O-])c1ccc(CBr)cc1>>COC(=O)c1ccc(CN2CCN(C(=O)OC(C)(C)C)CCC2=O)cc1,,C1CCOC1,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20110166158A1,COc1cccc(C(=O)O)n1.Nc1cccc(Oc2cccnc2)c1>>COc1cccc(C(=O)Nc2cccc(Oc3cccnc3)c2)n1,,ClCCl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160096827A1,N#Cc1cc(-c2ncnc(Cl)n2)ccc1OC1CCOCC1.Nc1ccc(C2CCN(CC(F)F)CC2)cc1>>N#Cc1cc(-c2ncnc(Nc3ccc(C4CCN(CC(F)F)CC4)cc3)n2)ccc1OC1CCOCC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20140323464A1,Cn1c(=O)c(-c2ccccc2Cl)cc2cnc(Nc3cccc(CNC(=O)OC(C)(C)C)c3)nc21>>Cn1c(=O)c(-c2ccccc2Cl)cc2cnc(Nc3cccc(CN)c3)nc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030176454A1,COc1ccccc1C(Br)C=O.Cc1ncn(-c2cccc(NC(N)=S)c2)c1C>>COc1ccccc1-c1cnc(Nc2cccc(-n3cnc(C)c3C)c2)s1,,CCO,,,,val
US20060183909A1,COC(=O)c1cc(NS(=O)(=O)c2ccc(C)cc2)c2cccc(O)c2n1>>COC(=O)c1cc(N)c2cccc(O)c2n1,,O,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20060009453A1,CC(=O)N1CC(C)(C)c2ccc(NC(=O)c3ccc(F)c(Nc4ncccc4-c4ccncn4)c3)cc21>>CC1(C)CNc2cc(NC(=O)c3ccc(F)c(Nc4ncccc4-c4ccncn4)c3)ccc21,,CCO,,,,val
US07993494B2,Fc1cc(F)cc(Br)c1.c1ccc(-c2nccnc2-c2ccccc2)cc1>>Fc1cc(F)cc(-c2cnc(-c3ccccc3)c(-c3ccccc3)n2)c1,,CCCCCC,O,C1CCOC1,[Li]CCCC,val
US20080255113A1,CC(C)n1c(=O)c(C(=O)O)cc2c(Cl)cccc21.CCCCN1CCC(CN)CC1.Cl>>CCCCN1CCC(CNC(=O)c2cc3c(Cl)cccc3n(C(C)C)c2=O)CC1.Cl,,Cl,ClCCl,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20150031727A1,CCC(CC)N(CCNC(=O)OC(C)(C)C)Cc1cccc(C(=O)Nc2sc3c(c2C(=O)Nc2ccc(CCc4ccc(C(=O)OC)cc4)cc2)CCCC3)c1>>CCC(CC)N(CCN)Cc1cccc(C(=O)Nc2sc3c(c2C(=O)Nc2ccc(CCc4ccc(C(=O)OC)cc4)cc2)CCCC3)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130344023A1,CC(C)Cc1ccc(C(C)C(=O)NCCNC(=O)OC(C)(C)C)cc1.Cl>>CC(C)Cc1ccc(C(C)C(=O)NCC[NH3+])cc1.[Cl-],,C1CCOC1,,,,val
US20070060607A1,CCOC(=O)c1cnc(Cl)c2c(CBr)csc12.Oc1cccc(COc2ccc(Cl)cc2)c1>>CCOC(=O)c1cnc(Cl)c2c(COc3cccc(COc4ccc(Cl)cc4)c3)csc12,,C1CCOC1,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20040210080A1,CC(C)(C)C(=O)Nc1ccc(Br)cc1F.CCCCCC=O>>CCCCCC(O)c1ccc(NC(=O)C(C)(C)C)c(F)c1,,C1CCOC1,,[Li]CCCC,,val
US20060100229A1,CC(C)Cc1c2c(nn1C)c(N)nc1ccccc12.O=C(O)C(F)(F)F>>CC(C)Cc1c2c3c(nc(N)c2nn1C)CCCC3.O=C(O)C(F)(F)F,O=[Pt]=O,ClC(Cl)Cl,,,,val
US20050004095A1,Nc1nc(/C(=N/OC(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)N[C@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(Cl)CCC23)c(Cl)s1.Nc1nnc(S)s1>>Nc1nnc(SC2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)[C@H](NC(=O)/C(=N\OC(c4ccccc4)(c4ccccc4)c4ccccc4)c4nc(N)sc4Cl)C3CC2)s1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040138286A1,COc1ccc2[nH]ncc2c1>>Oc1ccc2[nH]ncc2c1,,ClCCl,,BrB(Br)Br,O,val
US20150087646A1,NC(=O)c1cc(S(=O)(=O)NC2CC2)ccc1Cl.O=C(Cl)C(=O)Cl>>O=C=NC(=O)c1cc(S(=O)(=O)NC2CC2)ccc1Cl,,ClCCCl,,,,val
US20050171103A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(Br)cc1.OB(O)c1ccncc1>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(-c2ccncc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,O=C([O-])O.[Na+],,val
US20120220565A1,CC(C)(C)[Si](C)(C)Cl.OCC1CC(OCc2ccccc2)C1>>CC(C)(C)[Si](C)(C)OCC1CC(OCc2ccccc2)C1,,CN(C)C=O,,c1c[nH]cn1,,val
US04866077,CC(C)(N)CO.COC(=O)c1cccnc1>>CC1(C)COC(c2cccnc2)=N1,,Cc1ccccc1,,O,,val
US20100331312A1,C[C@@H]1CCCN1CCc1ccc(O)cc1F.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>C[C@@H]1CCCN1CCc1ccc(OS(=O)(=O)C(F)(F)F)cc1F,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US05741796,COC(=O)c1ccc(CCC#N)cc1.COC(CN)OC.Cl>>COC(=O)c1ccc(CCc2ncc[nH]2)cc1.Cl,,CCOCC,,CO,,val
US20150307497A1,BrCc1ccccc1.Oc1c(F)cc(Br)cc1Br>>Fc1cc(Br)cc(Br)c1OCc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US03940486,COC(=O)Cc1ccccc1.COC(=O)c1cccnc1>>O=C(Cc1ccccc1)c1cccnc1,,ClC(Cl)Cl,O,Cl,C[O-].[Na+],val
US20140179676A1,Cc1cc2c(cnn2-c2ccc(F)cc2)cc1C=O.Cn1nc(-c2ccccn2)cc1N.O=C(O)CS>>Cc1cc2c(cnn2-c2ccc(F)cc2)cc1C1SCC(=O)Nc2c1c(-c1ccccn1)nn2C,,O,,,,val
US04962110,CC1CC(=O)NN=C1c1ccc(N)cc1.CSc1nc2ccccc2c(=O)[nH]1>>CC1CC(=O)NN=C1c1ccc(Nc2nc(=O)c3ccccc3[nH]2)cc1,,c1ccncc1,,,,val
US20150011551A1,COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(C(=O)O)c1.NC1CCCCC1>>COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(C(=O)NC2CCCCC2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150329538A1,CC(=O)c1cccc2nc(C)c(F)nc12.CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F>>C=C(O[Si](C)(C)C(C)(C)C)c1cccc2nc(C)c(F)nc12,,ClCCl,,,,val
US05041462,CC(=O)OCC(=O)Cl.CCNc1cccc(N)c1C#N>>CCNc1cccc(NC(=O)COC(C)=O)c1C#N,,ClCCl,,O,c1ccncc1,val
US20140231754A1,COc1ccc(-c2ccc3c(c2)C(C)(C)c2cc(Br)ccc2-3)c(-c2ccccc2)c1.OB(O)c1ccccc1-c1ccccc1>>COc1ccc(-c2ccc3c(c2)C(C)(C)c2cc(-c4ccccc4-c4ccccc4)ccc2-3)c(-c2ccccc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20140228361A1,O=C1c2ccncc2C(=O)N1Cc1ccccc1>>O=C1C2CCNCC2C(=O)N1Cc1ccccc1,[Pd],COCCO,,O,,val
US20040229868A1,CCO.CCOC(=O)COc1cc(C2OCCCO2)ccc1[N+](=O)[O-]>>O=C1CCc2cc(C3OCCCO3)ccc2N1,[Zn],CCO,O,[Ca+2].[Cl-].[Cl-],,val
US04327101,CCOC(=O)c1cn(CCF)c2c(F)c(C)c(F)cc2c1=O>>Cc1c(F)cc2c(=O)c(C(=O)O)cn(CCF)c2c1F,,CCO,,[Na+].[OH-],,val
US20140142098A1,CC(=O)C(=NO)c1ccccc1.CNc1nc(C=O)cn2c(C)nnc12.NCc1ccccc1>>CNc1nc(-c2nc(-c3ccccc3)c(C)n2Cc2ccccc2)cn2c(C)nnc12,,CC(=O)O,,O,,val
US20150051171A1,COc1ccccc1-n1ccc(O)n1.Cn1nnn(-c2cccc(C3CC3)c2CBr)c1=O>>COc1ccccc1-n1ccc(OCc2c(C3CC3)cccc2-n2nnn(C)c2=O)n1,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20120058988A1,CC(=O)O.COc1cccc(-c2ccc(Nc3cccnc3)c(C#N)c2)c1>>COc1cccc(-c2cc(C(N)=O)c3[nH]c4cccnc4c3c2)c1,CC(=O)O[Pd]OC(C)=O,CO,,Cl,,val
US20090075979A1,CCOC(=O)C[C@@H]1CC[C@@H](C(=O)Nc2ccc(OC(F)(F)F)cc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC1.CI>>CCOC(=O)C[C@@H]1CC[C@@H](C(=O)N(C)c2ccc(OC(F)(F)F)cc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC1,,C1CCOC1,,[H-].[Na+],,val
US20030162806A1,CC(=O)NC(C)(C)CNc1c(C)c(C)nc(Oc2ccccc2)c1[N+](=O)[O-]>>CC(=O)NC(C)(C)CNc1c(C)c(C)nc(Oc2ccccc2)c1N,,Cc1ccccc1,,,,val
US05268389,CC(C)OC(=O)c1cc(N)c(F)cc1Cl.O=C(Cl)c1ccccc1>>CC(C)OC(=O)c1cc(NC(=O)c2ccccc2)c(F)cc1Cl,,CCC(C)=O,,,,val
US20100041628A1,COC(=O)c1ccc2c(C(N)=O)c(NC(N)=O)[nH]c2c1>>NC(=O)Nc1[nH]c2cc(C(=O)O)ccc2c1C(N)=O,,C1CCOC1,,CO,O,val
US20140309225A1,COCCOc1ncc(C(=O)OC)cc1F>>COCCOc1ncc(C(=O)O)cc1F,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20120029190A1,BrBr.CC(C)(C)OC(=O)N1CCC(=O)CC1>>Br.O=C1CCNCC1Br,,ClC(Cl)Cl,,,,val
US20140235628A1,NOS(=O)(=O)O.O=Cc1c(F)ccc(I)c1Cl>>N#Cc1c(F)ccc(I)c1Cl,,O,,,,val
US20050171114A1,CCCC(=O)Cl.COc1cc2c(c3c1c(=O)c1cc4ccccc4nc1n3C)[C@@H](O)[C@@H](O)C(C)(C)O2>>CCCC(=O)O[C@@H]1[C@H](O)c2c(cc(OC)c3c(=O)c4cc5ccccc5nc4n(C)c23)OC1(C)C,CN(C)c1ccncc1,c1ccncc1,,,,val
US05627203,O=C(c1cc(Cl)ccc1-n1cccc1)N1CCCC1>>O=C1c2cc(Cl)ccc2-n2cccc21,,O=P(Cl)(Cl)Cl,,,,val
US20050277676A1,CC(C)(C)OC(=O)N1CCC(COC(=O)Nc2ccc(-c3nc(Cl)cs3)cc2)CC1.Cl>>Cl.O=C(O)Nc1ccc(-c2nc(Cl)cs2)cc1,,C1COCCO1,CO,,,val
US05153226,CCOC(=O)c1ccc(C(NCC(=O)Nc2c(C(C)C)cccc2C(C)C)c2ccccc2)cc1>>CC(C)c1cccc(C(C)C)c1NC(=O)CNC(c1ccccc1)c1ccc(C(=O)O)cc1,,CO,,[Na+].[OH-],,val
US05112829,O=C1COc2cccc3nc4c(c(c23)N1Cc1ccccc1)CCCC4>>c1ccc(CN2CCOc3cccc4nc5c(c2c34)CCCC5)cc1,,C1CCOC1,,B,,val
US20150166559A1,COC(=O)C1=C(O)c2cc(C)c(C#N)c(=O)n2C1>>Cc1cc2n(c(=O)c1C#N)CCC2=O,,CC(=O)O,,Cl,,val
US20100087429A1,CC(C)(C)CCO.O=c1c2cc(-c3cncnc3)ccc2oc2ccnc(Cl)c12>>CC(C)(C)CCOc1nccc2oc3ccc(-c4cncnc4)cc3c(=O)c12,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130237518A1,CC(C)[Si](C#Cc1ccc2c(c1)c(-c1ccncc1)nn2C(=O)OC(C)(C)C)(C(C)C)C(C)C>>C#Cc1ccc2c(c1)c(-c1ccncc1)nn2C(=O)OC(C)(C)C,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04100277,CC1(C)OCCC(=O)c2ccccc2NC1=O.NO>>CC1(C)OCCC(=NO)c2ccccc2NC1=O,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20130217671A1,Cl.O=C(c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)cc2c1N[C@@H]1CC[C@@H](CN2CCCC2)CC1)C1CC1>>Cl.O=C(c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)cc2c1N[C@@H]1CC[C@@H](CN2CCCC2)CC1)C1CC1,,CO,,O,,val
US20060223849A1,O=C(Cl)c1ccccc1.O=C(Nc1nc2cccc(C(=O)Nc3nc4c(s3)CNCC4)c2[nH]1)c1cc2ccccc2cn1>>O=C(Nc1nc2c(C(=O)Nc3nc4c(s3)CN(C(=O)c3ccccc3)CC4)cccc2[nH]1)c1cc2ccccc2cn1,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US05495046,CCCN(CCC)CCCc1cc(Cl)ccc1OCCc1ccccc1.O=C(O)C(=O)O>>CCCN(CCC)CCCc1cc(Cl)ccc1OCCc1ccccc1.O=C(O)C(=O)O,,CCO,,,,val
US20150284395A1,CC(=O)N(C)C.NC(=O)c1cnn2c(=O)cc(-c3ccc4c(c3)OCCO4)[nH]c12>>C/C(=N\C(=O)c1cnn2c(=O)cc(-c3ccc4c(c3)OCCO4)[nH]c12)N(C)C,,CN(C)C=O,,CC(=O)N(C)C,,val
US20140343285A1,O=C1OC[C@@H](c2ccccc2)N1C(=O)[C@@H]1CO[C@@](CI)(c2ccc(F)cc2F)C1.OO>>O=C(O)[C@@H]1CO[C@@](CI)(c2ccc(F)cc2F)C1,,C1CCOC1,,O,[Na+].[OH-],val
US05750531,Cc1cc(F)ccc1N.ClC1(N2CCc3ccccc3C2)N=CN=C2C=CC=C21>>Cc1cc(F)ccc1NC1(N2CCc3ccccc3C2)N=CC2=CC=CC2=N1.Cl,,CN(C)C=O,,,,val
US20160237072A1,O=C(O)C12CCCCC1C2>>OCC12CCCCC1C2,,C1CCOC1,,B,,val
US20100190782A1,CCOC(=O)c1nc(-c2ccc3c(c2)N(C(C)=O)CCC3)sc1-c1ccc(OC)cc1>>COc1ccc(-c2sc(-c3ccc4c(c3)NCCC4)nc2C(=O)O)cc1,,O,,CO,[K+].[OH-],val
US20110257225A1,CC(=O)Cl.NC1CCCCC1>>CC(=O)NC1CCCCC1,,ClCCl,,CCN(CC)CC,,val
US05922725,CCCC[Sn](CCCC)(CCCC)c1nccs1.N#Cc1ccc2c(c1)ncn2-c1cccc(I)c1>>N#Cc1ccc2c(c1)ncn2-c1cccc(-c2nccs2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,,,val
US20140066424A1,Cc1nc(C#N)nn1Cc1cccc(N2CCN(C)CC2)c1.NO>>Cc1nc(C(=N)NO)nn1Cc1cccc(N2CCN(C)CC2)c1,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20030225059A1,CC(C)(C)OC(=O)N1CCC2(CCOC2)CC1>>C1CC2(CCN1)CCOC2,,CO,,Cl,,val
US06002008,CC#CC(=O)O.N#Cc1cnc2ccc(N)cc2c1Nc1ccc(Br)c(Br)c1>>CC#CC(=O)Nc1ccc2ncc(C#N)c(Nc3ccc(Br)c(Br)c3)c2c1,,C1CCOC1,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20100179148A1,CCOC(=O)Nc1cccc(CO)c1.N#Cc1ccc(=O)[nH]n1>>CCOC(=O)Nc1cccc(Cn2nc(C#N)ccc2=O)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150197509A1,COC(=O)CNCC(C)O.O=S(=O)(Cl)c1ccc(F)cc1>>COC(=O)CN(CC(C)O)S(=O)(=O)c1ccc(F)cc1,,ClCCl,,CCN(CC)CC,,val
US20050209241A1,CC(C)S(=O)(=O)c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)c(F)c1F.Cl>>CC(C)S(=O)(=O)c1ccc(N2CCNCC2)c(F)c1F.Cl,,C1COCCO1,,,,val
US20030018032A1,Nc1ccccn1.O=Cc1sccc1Br.[C-]#[N+]C1CCCCC1>>Brc1ccsc1-c1nc2ccccn2c1NC1CCCCC1,,[O-][Cl+3]([O-])([O-])O,,,,val
US20040048826A1,CC(C)C(=O)Cl.Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2OCCCCn2ccnc2)c(=O)[nH]1>>CC(C)C(=O)Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2OCCCCn2ccnc2)c(=O)[nH]1,,c1ccncc1,,C[Si](C)(C)Cl,,val
US20020055505A1,COC(=O)C(CCS(N)(=O)=O)c1ccc([N+](=O)[O-])cc1F>>O=C1NS(=O)(=O)CCC1c1ccc([N+](=O)[O-])cc1F,,C1CCOC1,CCCCCC,CO,[H-].[Na+],val
US20150322056A1,Clc1cnnc(Cl)c1.Ic1cc[nH]n1>>Clc1cc(-n2ccc(I)n2)cnn1,,CCOC(C)=O,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US20020006922A1,CCC(CC)CBr.CCOC(=O)CSc1ccc(O)cc1>>CCOC(=O)CSc1ccc(OCC(CC)CC)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04215127,COC(C)(C)C(=O)CBr.Oc1ccc(Cl)cc1Cl>>COC(C)(C)C(=O)COc1ccc(Cl)cc1Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130203727A1,Cc1cc2ccc(C#CC3CCCC3)cc2c(-c2ccc(Cl)cc2)c1C(OC(C)(C)C)C(=O)O>>Cc1cc2ccc(CCC3CCCC3)cc2c(-c2ccc(Cl)cc2)c1C(OC(C)(C)C)C(=O)O,,CC#N,O,,,val
US20070299081A1,CC(C)(C)OC(=O)N1CCC(N(C(=O)C(F)(F)Br)c2ccccc2I)CC1>>CC(C)(C)OC(=O)N1CCC(N2C(=O)C(F)(F)c3ccccc32)CC1,[Cu],CS(C)=O,,,,val
US20110195094A1,CCOCOc1cc(OCc2ccccc2)c(/C=N/NC(=O)Nc2ccc3c(ccn3C)c2)cc1C(C)C>>CCOCOc1cc(OCc2ccccc2)c(-c2n[nH]c(=O)n2-c2ccc3c(ccn3C)c2)cc1C(C)C,,CCO,,[Na+].[OH-],,val
US20090130090A1,COc1ccc(F)cc1N.O=C(Cl)OC(Cl)(Cl)Cl>>COc1ccc(F)cc1N=C=O,,C1COCCO1,,,,val
US20040102433A1,C=CCOC(=O)Cl.COC(=O)C1=CCC(C)N(Cc2ccccc2)C1>>C=CCOC(=O)N1CC(C(=O)OC)=CCC1C,,C1CCOC1,,CCOC(C)=O,O=C([O-])O.[Na+],val
US20100094000A1,C1COCCN1.Cc1ccc(S(=O)(=O)OCCn2nc(C)c(Br)c2-c2ccc(F)cc2)cc1>>Cc1nn(CCN2CCOCC2)c(-c2ccc(F)cc2)c1Br,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20090143353A1,CN[C@H]1CCNC1.Cc1c(-c2cccs2)c(F)c2oc(C(=O)N(C)C)nc2c1C#N>>CN[C@H]1CCN(c2c(-c3cccs3)c(C)c(C#N)c3nc(C(=O)N(C)C)oc23)C1,,CS(C)=O,,CCN(CC)CC,,val
US20030045558A1,CCOC(=O)c1ccc(-c2cccc(-c3nc(CCOc4cccc(OC(C)(C)C(=O)OCC)c4)c(C)o3)c2)cc1>>Cc1oc(-c2cccc(-c3ccc(C(=O)O)cc3)c2)nc1CCOc1cccc(OC(C)(C)C(=O)O)c1,,CCO,,Cl,[Na+].[OH-],val
US20100267718A1,C[C@H]1CN(CCO)C(=O)O1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCCN2C[C@H](C)OC2=O)cc1,,c1ccncc1,,CCOC(C)=O,Cl,val
US04243683,O=C(C=P(c1ccccc1)(c1ccccc1)c1ccccc1)CBr.Sc1ccccc1>>O=C(C=P(c1ccccc1)(c1ccccc1)c1ccccc1)CSc1ccccc1,,CCO,,O,[Na],val
US20040106800A1,CI.O=S(=O)(NC(=S)N1CC(c2ccccc2)C(c2ccc(Cl)cc2)=N1)N1CCCCC1>>CSC(=NS(=O)(=O)N1CCCCC1)N1CC(c2ccccc2)C(c2ccc(Cl)cc2)=N1,,CC(C)=O,,CCN(CC)CC,,val
US04835165,Clc1ccncc1.NS(=O)(=O)c1ccc(C2CCNCC2)cc1>>NS(=O)(=O)c1ccc(C2CCN(c3ccncc3)CC2)cc1,,CC(C)CCO,,Cl,O=C([O-])O.[Na+],val
US20090253687A1,O=C1COc2ccc(C3=C(c4ccc(F)cc4)C(=O)OC3)cc2N1.O=O>>O=C1COc2ccc(C3=C(c4ccc(F)cc4)C(=O)OC3=O)cc2N1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US05696276,CCI.COc1ccc(OC)c2c(OC)c(C(O)CCC(C)C)cc(OC)c12>>CCOC(CCC(C)C)c1cc(OC)c2c(OC)ccc(OC)c2c1OC,,C1CCOC1,,[H-].[Na+],,val
US20120040950A1,C=C1c2nc(-c3cnc(OC)c(OC)c3)ccc2C(=O)N1c1cnn(CC(F)(F)F)c1>>COc1cc(-c2ccc3c(n2)C(C)N(c2cnn(CC(F)(F)F)c2)C3=O)cnc1OC,[Pd],C1CCOC1,,,,val
US20050004137A1,O=C1N=c2ccc(CCBr)cc2=N1.c1ccc2c(N3CCNCC3)cccc2c1>>O=C1N=c2ccc(CCN3CCN(c4cccc5ccccc45)CC3)cc2=N1,,CC(=O)CC(C)C,,[I-].[Na+],,val
US20100004292A1,CS(=O)(=O)O.CSc1nc(NC(=O)c2ccc(Cl)s2)c(C(=O)Nc2ccc(N3CCOC3=N)cc2)s1.OO>>CS(=O)(=O)c1nc(NC(=O)c2ccc(Cl)s2)c(C(=O)Nc2ccc(N3CCOC3=N)cc2)s1,,CC(=O)O,,C1CCOC1,,val
US04908372,CC(C)(C)OC(=O)N1CCC(C(=O)c2nc3ccccc3n2Cc2ccc(F)cc2)CC1>>O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCNCC1,,CCOCC,,O=C(O)C(F)(F)F,,val
US20070219210A1,CC(C)(C)N.NC(=O)CBr>>CC(C)(C)NCC(N)=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120010228A1,CC(C)(C)OC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCN(CCCN4C(=O)C(F)(F)c5ccccc54)CC3)C2=O)c1>>O=C(O)c1cccc(CN2CN(c3ccccc3)C3(CCN(CCCN4C(=O)C(F)(F)c5ccccc54)CC3)C2=O)c1,,C1COCCO1,Cl,,,val
US20140011802A1,O=C(NC1=N[C@@]2(c3ccc(F)cc3F)CO[C@H](CO)[C@H]2CS1)c1ccccc1.O=S(=O)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>O=C(NC1=N[C@@]2(c3ccc(F)cc3F)CO[C@H](CF)[C@H]2CS1)c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20160168132A1,CSC.Nc1nc(Cl)cc(Cl)n1>>CSc1cc(Cl)nc(N)n1,,CN(C)C=O,,[Na],,val
US20110105461A1,COCCN.Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1>>COCCNCC1COc2c(F)cc(S(C)(=O)=O)cc2O1,,CC#N,,,,val
US20100160388A1,CC(C)(C)[Si](C)(C)OCCOc1cc(N)c(Br)cc1Cl.O=C(Cl)Cl>>CC(C)(C)[Si](C)(C)OCCOc1cc(N=C=O)c(Br)cc1Cl,CN(C)c1ccncc1,Cc1ccccc1,,c1ccncc1,,val
US20140142083A1,CCN(c1cc(Cl)cc(C(=O)OC)c1Br)C1CCOCC1>>CCN(c1cc(Cl)cc(C(=O)O)c1Br)C1CCOCC1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20090238808A1,Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(CNC(=O)OC(C)(C)C)cc3)cc21>>Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(CN)cc3)cc21,,CO,,Cl,,val
US20150342930A1,Clc1cc(OCc2c(-c3c(Cl)cccc3Cl)noc2C2CC2)ccc1Br.O=C1CC(c2cccc(Br)c2)C1>>OC1(c2ccc(OCc3c(-c4c(Cl)cccc4Cl)noc3C3CC3)cc2Cl)CC(c2cccc(Br)c2)C1,,C1CCOC1,,[Li]CCCC,,val
US20160095844A1,CNN.COc1ccc(CN2C(=O)C(C)(C)c3ccc(C(=O)CC(C)=O)cc32)cc1>>COc1ccc(CN2C(=O)C(C)(C)c3ccc(-c4cc(C)nn4C)cc32)cc1,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20040106606A1,CN(C)C=O.Cc1cc(S)c(C(C)(C)C)cc1NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)n1ccc2cc(S)c(C(C)(C)C)cc21,,C1CCOC1,,[Li]C(C)CC,,val
US20130089512A1,O=[N+]([O-])c1cnc(-c2cnc3ccc(F)cn23)nc1NCc1ccccn1>>Nc1cnc(-c2cnc3ccc(F)cn23)nc1NCc1ccccn1,[Pd],CCO,,,,val
US20140343050A1,CC(C)(C)OC(=O)N[C@H](CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)C(=O)OCCC(F)(F)F>>CC(C)(C)OC(=O)N[C@H](CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)C(=O)OCCC(F)(F)F,[Pd],CCO,,[H][H],,val
US07358386B2,CC(=O)Cl.CCC(C(=O)OC)C1CCc2cc(OC)ccc21>>CCC(C(=O)OC)C1CCc2cc(OC)c(C(C)=O)cc21,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20110217311A1,CI.O=[N+]([O-])c1ccc(F)cc1O[C@@H]1CC[C@@H](O)CC1>>CO[C@@H]1CC[C@@H](Oc2cc(F)ccc2[N+](=O)[O-])CC1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20090163508A1,Fc1ccc(F)c(-c2ccnc(N3CCNCC3)n2)c1.O=C(Nc1cccnn1)OCC(Cl)(Cl)Cl>>O=C(Nc1cccnn1)N1CCN(c2nccc(-c3cc(F)ccc3F)n2)CC1,,C1CCOC1,CCCCCC,Cl,Cl,val
US20150119380A1,Cc1cn2cc(-c3cc4ccc(C5(F)CCN(C(=O)OCc6ccccc6)CC5)cc4oc3=O)nc2c(C)n1>>Cc1cn2cc(-c3cc4ccc(C5(F)CCNCC5)cc4oc3=O)nc2c(C)n1,[Pd],CO,ClCCl,,,val
US20130026452A1,Clc1ccc(Cl)nc1.OB(O)c1ccccc1>>Clc1ccc(-c2ccccc2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US04988705,O=C(O)c1cccnc1Nc1cccc(Cl)c1.O=S(Cl)Cl>>O=C(Cl)c1cccnc1Nc1cccc(Cl)c1,,CN(C)C=O,,,,val
US20110160221A1,CC(C)(C)OC(=O)N1CCN(C(=O)Cl)CC1.CCN(CC)CCNc1ccc(Cl)cc1>>CCN(CC)CCN(C(=O)N1CCN(C(=O)OC(C)(C)C)CC1)c1ccc(Cl)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06653491B1,CC(C)(C)[Si](C)(C)Cl.COC(=O)C[C@H]1CC=C2C3=C(CC[C@@]21C)[C@@]1(C)CC[C@H](O)C(C)(C)C1CC3>>COC(=O)C[C@H]1CC=C2C3=C(CC[C@@]21C)[C@@]1(C)CC[C@H](O[Si](C)(C)C(C)(C)C)C(C)(C)C1CC3,,CN(C)C=O,,c1c[nH]cn1,,val
US04816452,CCOC(=O)/C(=N\OCC=C(Cl)Cl)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>CCOC(=O)/C(=N\OCC=C(Cl)Cl)c1csc(N)n1,,O=CO,,O,,val
US20160264598A1,CC(=O)NC1Cc2cccc(C(=O)O)c2OB1O.CC(=O)OCCBr>>CC(=O)N[C@H]1Cc2cccc(C(=O)OC(C)OC(C)=O)c2OB1O,,CC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20040259875A1,CC(C)(C)OC(=O)Nc1ccc(Br)c2ccc(O)cc12>>Nc1ccc(Br)c2ccc(O)cc12,,C1COCCO1,Cl,,,val
US20120329791A1,CC1(C)OB(c2cccc(N)c2)OC1(C)C.O=C(Cl)C1COCCO1>>CC1(C)OB(c2cccc(NC(=O)C3COCCO3)c2)OC1(C)C,,CC(=O)N(C)C,CCOC(C)=O,CCN(CC)CC,,val
US05321135,COc1cc(/C=C2/C(=O)OC[C@H]2Cc2cc(OC)c3c(c2)OCO3)cc(OC)c1OC>>COc1cc(C[C@@H]2COC(=O)/C2=C/c2cc(OC)c(OC)c(OC)c2)cc(O)c1O,,ClCCl,,ClB(Cl)Cl,,val
US04975439,CO[C@@H]1CNCC[C@@H]1N(C)C.O=C(Cl)CCCCl>>CO[C@@H]1CN(C(=O)CCCCl)CC[C@@H]1N(C)C,,ClCCl,,CCN(CC)CC,,val
US04521422,C1CCNC1.CN(C)C=CC(=O)c1cccnc1>>O=C(C=CN1CCCC1)c1cccnc1,,Cc1ccccc1C,,,,val
US05359055,CC(=O)OC(C)=O.COC(OC)C(C)[C@H]1CC[C@H]2[C@@H]3[C@@H]4O[C@]45OC4=C5[C@](C)(CC[C@@H]4O)[C@H]3CC[C@]12C>>COC(OC)C(C)[C@H]1CC[C@H]2[C@@H]3[C@@H]4O[C@]45OC4=C5[C@](C)(CC[C@@H]4OC(C)=O)[C@H]3CC[C@]12C,,ClCCl,,c1ccncc1,,val
US20070117824A1,CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1N.CCOC(C)=O.ClCc1ccc(Cl)nc1>>CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(Cl)nc1,,c1ccncc1,,,,val
US04964895,COc1cc(F)ccc1[N+](=O)[O-].Cn1nc(O)c(Cl)c1C(F)(F)F>>COc1cc(Oc2nn(C)c(C(F)(F)F)c2Cl)ccc1[N+](=O)[O-],,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160083403A1,CC(C)NN.COc1cccc(C(=O)NN(C(=O)c2ccc(C=O)c(B3OC(C)(C)C(C)(C)O3)c2)C(C)(C)C)c1C>>COc1cccc(C(=O)NN(C(=O)c2ccc3c(c2)B(O)N(C(C)C)N=C3)C(C)(C)C)c1C,,CCO,,,,val
US20080004309A1,CCOC(=O)c1ncc2nc(-c3cccc(OC)c3)sc2c1O.O=C1CCC(=O)N1Br>>CCOC(=O)c1nc(Br)c2nc(-c3cccc(OC)c3)sc2c1O,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20110152273A1,COC(=O)c1c(C#N)cc(N[C@@H]2CCCC[C@@H]2NC(=O)OC(C)(C)C)nc1Nc1ccc2cn[nH]c2c1>>COC(=O)c1c(C#N)cc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1ccc2cn[nH]c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080255186A1,CCn1ncc2c(NC3CCOCC3)c(CN=[N+]=[N-])cnc21>>CCn1ncc2c(NC3CCOCC3)c(CN)cnc21,[Pd],CCO,,,,val
US20120225867A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.N#Cc1c[nH]cn1>>N#Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,,CCCCCC,O,CC#N,CCN(CC)CC,val
US20100239576A1,COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@H](C)OC(=O)[C@H](C)NC(=O)OCc5ccccc5)n(-c5ccccc5)c4=O)cc3F)ccnc2c1>>COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@H](C)OC(=O)[C@H](C)N)n(-c5ccccc5)c4=O)cc3F)ccnc2c1,[Pd],CCOC(C)=O,,CO,,val
US20070293516A1,COc1cc(Br)cc(-c2nn(C(C)C)c3ncnc(N)c23)c1>>CC(C)n1nc(-c2cc(O)cc(Br)c2)c2c(N)ncnc21,,ClCCl,,BrB(Br)Br,,val
US07122678B2,CCOC(=O)CC1(C[N+](=O)[O-])CCC(C)(C)C1>>CC1(C)CCC2(CNC(=O)C2)C1,[Ni],CO,,,,val
US04632969,C=CCO.O=C(Cl)c1ccccc1Cl>>C=CCOC(=O)c1ccccc1Cl,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20130115310A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ncc(Br)nc1-c1cc(-c2ccccc2)no1.CC(C)(C)OC(=O)N1CCCC(S(=O)(=O)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)C1>>CC(C)(C)OC(=O)Nc1ncc(-c2ccc(S(=O)(=O)C3CCCN(C(=O)OC(C)(C)C)C3)cc2)nc1-c1cc(-c2ccccc2)no1,,CC#N,,O,O=C([O-])[O-].[Na+].[Na+],val
US20150225423A1,Cc1cc(O)nc(S)n1.Clc1ccnn1CBr>>Cc1cc(O)nc(SCn2nccc2Cl)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030186962A1,Br[Mg]c1ccccc1.C(=NCc1ccccc1)[C@@H](COCc1ccccc1)OCc1ccccc1>>c1ccc(CN[C@H](c2ccccc2)[C@@H](COCc2ccccc2)OCc2ccccc2)cc1,,CCOCC,,[Cl-].[NH4+],,val
US20110263549A1,Cc1cc(-c2cc3ncccc3c(Cl)n2)ccc1N(C)C.O=C1CC(CO)CN1>>Cc1cc(-c2cc3ncccc3c(OCC3CNC(=O)C3)n2)ccc1N(C)C,,CC(=O)N(C)C,,[H-].[Na+],,val
US20120184548A1,NCc1cccc(Cl)c1.Nc1cc(C(=O)O)ccc1Cl>>Nc1cc(C(=O)NCc2cccc(Cl)c2)ccc1Cl,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050059702A1,CS(=O)(=O)OCCc1ccccn1.Cc1cccnc1[C@@H]1CCC[C@H](c2ncccc2C)N1>>Cc1cccnc1[C@@H]1CCC[C@H](c2ncccc2C)N1CCc1ccccn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090143385A1,CCOC(=O)c1ccc(OCc2c(-c3ccccc3)noc2C)nn1>>Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)nn1,,CCO,,[Na+].[OH-],,val
US05318975,CCc1ncncc1N.CCn1cnc(C(=O)O)c1>>CCc1ncncc1NC(=O)c1cn(CC)cn1,,C1CCOC1,,O=S(Cl)Cl,c1ccncc1,val
US04424219,COc1cc2cc(c1Cl)N(C)C(=O)CC(O)C1(C)OC1C(C)C1CC(O)(NC(=O)O1)C(OC)C=CC=C(C)C2.O=C(O)C1CCC1>>COc1cc2cc(c1Cl)N(C)C(=O)CC(O)C1(C)OC1C(C)C1CC(O)(NC(=O)O1)C(OC)C=CC=C(C)C2.O=C([O-])C1CCC1,CN(C)c1ccncc1,ClCCl,,O,,val
US20100267634A1,CCN(CC)[C@@H](C(=O)O)c1ccccc1.COC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)Nc1ccc(CN(Cc2ccc(NC(=O)[C@@H]3CCCN3)cc2)c2ccccc2)cc1)C(C)(C)C>>CCN(CC)[C@@H](C(=O)N1CCC[C@H]1C(=O)Nc1ccc(CN(Cc2ccc(NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)OC)C(C)(C)C)cc2)c2ccccc2)cc1)c1ccccc1,,CS(C)=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070072885A1,Cc1cc([N+](=O)[O-])ccc1Oc1ccc(CO)nc1.O=C(OO)c1cccc(Cl)c1>>Cc1cc([N+](=O)[O-])ccc1Oc1ccc(CO)[n+]([O-])c1,,ClCCl,,,,val
US20050222261A1,CCNCc1ccc(C(C)(C)C)cc1.COC(=O)c1ccccc1OCCc1ccc(OCC(=O)Cl)cc1>>CCN(Cc1ccc(C(C)(C)C)cc1)C(=O)COc1ccc(CCOc2ccccc2C(=O)OC)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20110195954A1,Fc1ccc2c(c1)CCN2.O=C(Cl)c1cc(Cl)nc(Cl)c1>>O=C(c1cc(Cl)nc(Cl)c1)N1CCc2cc(F)ccc21,,ClCCl,,[Na+].[OH-],,val
US20040133011A1,CC1(CCCC23CCC(c4nnc(-c5ccccc5C(F)(F)F)o4)(CC2)CC3)OCCO1>>CC(=O)CCCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)o3)(CC1)CC2,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140296243A1,CN[C@H](C)c1ccccc1.Cc1nnc2ccc(Cl)nn12>>Cc1nnc2ccc(N(C)[C@H](C)c3ccccc3)nn12,,CN1CCCC1=O,,,,val
US06326359B1,COC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CN)nc32)[C@H](O)[C@@H]1O.O=C1CCCCC1>>COC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CNC4CCCCC4)nc32)[C@H](O)[C@@H]1O,,C1CCOC1,CCOCC,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20080280920A1,CC(C)(C)OC(=O)Nc1ccc(O)c(C(=O)NCCOC(=O)Oc2ccc([N+](=O)[O-])cc2)c1.NCCNC(=O)c1cc(OCc2ccccc2)ccc1OCc1ccccc1>>CC(C)(C)OC(=O)Nc1ccc(O)c(C(=O)NCCOC(=O)NCCNC(=O)c2cc(OCc3ccccc3)ccc2OCc2ccccc2)c1,,CN(C)C=O,,,,val
US20110230414A1,CC(C)(C)OC(=O)N[C@@H]1CCCNC1=O.CI>>CN1CCC[C@@H](NC(=O)OC(C)(C)C)C1=O,,CN(C)C=O,,O,[H-].[Na+],val
US20090163488A1,Cc1ccc(S(=O)(=O)Nc2ccc(Oc3cccc(NC(=O)c4cccc(C(C)(C)C#N)c4)c3)cn2)cc1.NC(=O)CI>>Cc1ccc(S(=O)(=O)N=c2ccc(Oc3cccc(NC(=O)c4cccc(C(C)(C)C#N)c4)c3)cn2CC(N)=O)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130196974A1,Cc1ccc2nc(Cl)nc(Cl)c2c1.[OH-]>>Cc1ccc2nc(Cl)[nH]c(=O)c2c1,,C1CCOC1,,CC(=O)O,,val
US20140275011A1,O=[N+]([O-])c1ccc(Br)cc1NCc1cccc(F)c1>>Nc1ccc(Br)cc1NCc1cccc(F)c1,[Ni],CO,O,NN,,val
US20130005716A1,CS(=O)(=O)Cl.Nc1ccc(S(=O)(=O)N2CCSC2C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)cc1>>CS(=O)(=O)Nc1ccc(S(=O)(=O)N2CCSC2C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)cc1,,ClCCl,,c1ccncc1,,val
US20060247250A1,Cc1cccc(C)c1C(=O)Nc1cnc(Nc2ccc(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)cc2)nc1>>Cc1cccc(C)c1C(=O)Nc1cnc(Nc2ccc(C(=O)N3CCNCC3)cc2)nc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20140275027A1,CC(C)(C)OC(=O)N1CC=C(c2cc3c(-c4cccc(F)n4)ccnc3n2S(=O)(=O)c2ccccc2)CC1>>CC(C)(C)OC(=O)N1CC=C(c2cc3c(-c4cccc(F)n4)ccnc3[nH]2)CC1,,C1COCCO1,O,[Na+].[OH-],,val
US20100130446A1,CC(O)c1cnc(-c2ccc(C(CC3CCOCC3)c3ccc(S(=O)(=O)C4CC4)cc3)[nH]2)s1.O=C1CCC(=O)N1Cl>>CC(O)c1cnc(-c2[nH]c(C(CC3CCOCC3)c3ccc(S(=O)(=O)C4CC4)cc3)cc2Cl)s1,,C1CCOC1,CCOC(C)=O,,,val
US20120295884A1,CC(C)(C)OC(=O)NCc1cc(C(=O)N2CCOCC2)cc(Cl)c1F>>NCc1cc(C(=O)N2CCOCC2)cc(Cl)c1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090192162A1,CCOC(=O)COc1ccc(Sc2cc(C#CCc3ccccc3)cc(OCCCN3CCOCC3)c2)cc1C>>Cc1cc(Sc2cc(C#CCc3ccccc3)cc(OCCCN3CCOCC3)c2)ccc1OCC(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20130059801A1,CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCSSCCN.O=C1CCC(=O)O1>>CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCSSCCNC(=O)CCC(=O)O,,ClCCl,,CCN(CC)CC,Cl,val
US20130245355A1,N#CCc1ccccc1F.[NH3+]O>>N=C(Cc1ccccc1F)NO,,CCO,,CCN(CC)CC,,val
US20130317026A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.Cc1cc(C)c(CNC(=O)c2cc(C3=CCNCC3)nc3c2cnn3C(C)C)c(=O)[nH]1>>Cc1cc(C)c(CNC(=O)c2cc(C3=CCN(C4CCN(C(=O)OC(C)(C)C)CC4)CC3)nc3c2cnn3C(C)C)c(=O)[nH]1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US04329471,Cc1c[nH]c(=O)[nH]1.O=C(Cl)c1ccc(F)cc1>>Cc1[nH]c(=O)[nH]c1C(=O)c1ccc(F)cc1,,O=[N+]([O-])c1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20150313864A1,CC1(C)OC(=O)/C(=C/C(=O)Cl)O1.CNC>>CN(C)C(=O)/C=C1\OC(C)(C)OC1=O,,ClCCl,,CCN(CC)CC,Cl,val
US05843942,COC(=O)c1cc(Br)ccc1O.OCc1cccs1>>COC(=O)c1cc(Br)ccc1OCc1cccs1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06498165B1,C#C[Sn](CCCC)(CCCC)CCCC.C[C@H](Nc1nccc(-n2cnc3ccc(N=[N+]=[N-])cc32)n1)c1ccccc1>>CCCC[Sn](CCCC)(CCCC)c1cn(-c2ccc3ncn(-c4ccnc(N[C@@H](C)c5ccccc5)n4)c3c2)nn1,,C1COCCO1,,,,val
US04859684,Nc1ccc(C(=O)c2ccccc2)cc1[N+](=O)[O-]>>Nc1ccc(C(O)c2ccccc2)cc1[N+](=O)[O-],,O,,CO,[BH4-].[Na+],val
US20100160308A1,CCOC(=O)c1sc(Nc2cc(OCc3ccccc3)ccc2[N+](=O)[O-])nc1-c1cccc(Cl)c1>>CCOC(=O)c1sc(Nc2cc(OCc3ccccc3)ccc2N)nc1-c1cccc(Cl)c1,[Zn],C1CCOC1,,Cl,,val
US20090054465A1,CCN(C(C)C)C(C)C.COC(=O)/C=C/c1cnc(N[C@@H]2CCNC2)cn1.O=CCCc1ccccc1>>COC(=O)/C=C/c1cnc(N[C@@H]2CCCN(CCCc3ccccc3)C2)cn1,,ClCCl,,O=C([O-])O.[Na+],,val
US20120270838A1,CC(O)Br.Cc1ccc(N)cc1Br>>Cc1ccc(NCCO)cc1Br,,Cc1ccccc1,,CCN(CC)CC,O,val
US20140121200A1,CC(=O)Cl.CC1(C)OB(c2ccc(N3CCNCC3)cc2)OC1(C)C>>CC(=O)N1CCN(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1,,C1CCOC1,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20070249612A1,CC(C)(C)c1cn2c(=O)[nH]nc2c(Cl)n1.CC(C)C=O.CC1(C)CCCC(C)(C)N1>>CC(C)CC(O)c1c(C(C)(C)C)nc(Cl)c2n[nH]c(=O)n12,,C1CCOC1,,[Li]CCCC,,val
US20110118245A1,CC(C)(c1cc(NC(=O)Oc2ccccc2)no1)C(F)(F)F.CCOc1cc2c(Oc3cccc(N)c3)ncnc2cc1OC>>CCOc1cc2c(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)ncnc2cc1OC,CN(C)c1ccncc1,C1CCOC1,,,,val
US20120115856A1,Nc1ccccc1S.O=C(O)c1ccc2c(c1)nc(COCc1ccccc1)n2-c1ccccc1>>c1ccc(COCc2nc3cc(-c4nc5ccccc5s4)ccc3n2-c2ccccc2)cc1,,C1CCOC1,,O=C(Cl)C(=O)Cl,,val
US20060287303A1,COc1ccc(Cl)cc1C1(OC)CCN(C(=O)OC(C)(C)C)CC1.Cl>>COc1ccc(Cl)cc1C1(OC)CCNCC1.Cl,,CO,Cl,,,val
US20050282858A1,O=S1(=O)NC2(CCN(Cc3ccccc3)C2)c2ccccc21>>O=S1(=O)NC2(CCNC2)c2ccccc21,[Pd],CO,,O=CO,,val
US06384028B1,CC(C)(C)OC(=O)N1CCC(/C=C/C(=O)N2CCC[C@@H](C(=O)NCCC(=O)O)C2)CC1>>O=C(O)CCNC(=O)[C@@H]1CCCN(C(=O)/C=C/C2CCNCC2)C1,,CCOC(C)=O,,Cl,,val
US20130338137A1,CC1(C)C(=O)Nc2nc(-c3nn(Cc4ccccc4F)c4ncccc34)nc(I)c21.CC1NCCNC1=O>>CC1C(=O)NCCN1c1nc(-c2nn(Cc3ccccc3F)c3ncccc23)nc2c1C(C)(C)C(=O)N2,,CN1CCCC1=O,,,,val
US20150225367A1,CC(=O)OC(C)=O.Nc1ccc(-c2cn(S(=O)(=O)c3ccccc3)c3cc(F)ccc23)cn1>>CC(=O)Nc1ccc(-c2cn(S(=O)(=O)c3ccccc3)c3cc(F)ccc23)cn1,,CN(C)C=O,,Cl,c1ccncc1,val
US20090111809A1,O=C1[C@H](Cc2c(Cl)cc(O)cc2Cl)CCN1N1CCC(O)CC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C1[C@H](Cc2c(Cl)cc(OS(=O)(=O)C(F)(F)F)cc2Cl)CCN1N1CCC(O)CC1,,ClCCl,,,,val
US20090264448A1,COc1c(C(=O)C=CN(C)C)cc(F)cc1N(C)C(C)=O.Nc1[nH]ncc1C(=O)c1cccs1>>COc1c(-c2ccnc3c(C(=O)c4cccs4)cnn23)cc(F)cc1N(C)C(C)=O,,CC(=O)O,,CCOC(C)=O,,val
US20120277224A1,CC(=O)C(C#N)Cc1ccccc1Cl.NN>>Cc1n[nH]c(N)c1Cc1ccccc1Cl,,CCO,,CCOCC,O,val
US07183260B2,CC(C)(C)OC(=O)CC(C=O)NC(=O)OCC1c2ccccc2-c2ccccc21.Cc1ccc(S(=O)(=O)O)cc1.OCc1ccccc1>>CC(C)(C)OC(=O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(OCc1ccccc1)OCc1ccccc1,,ClCCl,,O,,val
US20110053912A1,CCOC(=O)c1cnc(S(C)(=O)=O)nc1C(C)C.NC1CC2CCC1C2>>CCOC(=O)c1cnc(N[C@@H]2C[C@H]3CC[C@@H]2C3)nc1C(C)C,,O,,C1COCCO1,,val
US20080032972A1,COC(=O)C(C)(C)N.O=[N+]([O-])c1cc(I)cnc1Cl>>COC(=O)C(C)(C)Nc1ncc(I)cc1[N+](=O)[O-],,CCO,,CCN(CC)CC,Cl,val
US20120010244A1,CC(C)N1Cc2ccc(Br)cc2C1.COB(OC)OC>>CC(C)N1Cc2ccc(B(O)O)cc2C1,,C1CCOC1,,II,[Mg],val
US06057358,CC(=O)Nc1cc([N+](=O)[O-])ccc1O.CC(Br)Br>>CC(=O)Nc1cc([N+](=O)[O-])ccc1OCCBr,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04803301,C[C@H](O)C(=O)OC(C)(C)C.O=[N+]([O-])c1ccc(Oc2ccc(O)cc2)c([N+](=O)[O-])c1>>C[C@@H](Oc1ccc(Oc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])cc1)C(=O)OC(C)(C)C,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100173880A1,CCOC(=O)C(c1ccccc1)N(C)c1ccc(F)cc1.Cl>>CN(c1ccc(F)cc1)C(C(=O)O)c1ccccc1.Cl,,C1CCOC1,O,[Li+].[OH-],,val
US20090082440A1,CC(C)(COS(=O)(=O)CCCN1C(=O)c2ccccc2C1=O)[C@@H](OCc1ccccc1)C(=O)O.CCO>>CCOC(=O)[C@H](OCc1ccccc1)C(C)(C)COS(=O)(=O)CCCN1C(=O)c2ccccc2C1=O,,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US05190689,C=CCOC(=O)CCCCCCCCBr.CCCCCc1ccc(-c2ccc(CC(O)C3CCC(CCC)CC3)cc2)cc1>>C=CCOC(=O)CCCCCCCCOC(Cc1ccc(-c2ccc(CCCCC)cc2)cc1)C1CCC(CCC)CC1,,Cc1ccccc1,,[H][H],[H-].[Na+],val
US20050049245A1,CNCC(O)c1cc(C)c(C)o1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)sc21>>Cc1cc(C(O)CN(C)Cc2cc3c(=O)c(C(=O)NCc4ccc(Cl)cc4)cn(C)c3s2)oc1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US20140045819A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C1CCc2cc(Br)cc(F)c2N1>>Fc1cc(Br)cc2c1NC(=S)CC2,,Cc1ccccc1,,,,val
US20090042929A1,O=C(CSc1cc(Cl)ccc1Cl)C12CC3CC(CC(C3)C1)C2.O=C(OO)c1cccc(Cl)c1>>O=C(CS(=O)c1cc(Cl)ccc1Cl)C12CC3CC(CC(C3)C1)C2,,ClCCl,,,,val
US20110098324A1,CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(Cc2ccccc2Br)c1=O.NC1CCCCC1>>O=C(O)CNC(=O)c1c(O)c(C(=O)NC2CCCCC2)c(O)n(Cc2ccccc2Br)c1=O,,ClC(Cl)Cl,,Cl,,val
US05753664,CN(C)CCCl.Cc1cccc2nc(CCc3ccc(C(=O)c4ccc(O)cc4)cc3)n(C)c(=O)c12>>Cc1cccc2nc(CCc3ccc(C(=O)c4ccc(OCCN(C)C)cc4)cc3)n(C)c(=O)c12.Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050107377A1,CCNCC.Fc1ccc2c(-c3ccc(OC[C@H]4CO4)cc3)noc2c1>>CCN(CC)C[C@@H](O)COc1ccc(-c2noc3cc(F)ccc23)cc1,,CCO,CN(C)C=O,,,val
US20110312969A1,CCOC(=O)c1cccc(OCCCCl)c1.N=c1[nH]c2ccccc2[nH]1>>CCOC(=O)c1cccc(OCCCn2c(=N)[nH]c3ccccc32)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140187556A1,O=C(c1ccccc1)N1CCN(c2ccc(OC(F)F)c([N+](=O)[O-])c2)CC1>>Nc1cc(N2CCN(C(=O)c3ccccc3)CC2)ccc1OC(F)F,[Pd],CO,,,,val
US20060241115A1,CNC(=O)c1cc(Cl)ccn1.Nc1cccc2cc(O)ccc12>>CNC(=O)c1cc(Oc2ccc3c(N)cccc3c2)ccn1,,CN(C)C=O,ClC(Cl)Cl,[H-].[Na+],,val
US20100093740A1,CCc1nc(I)c2n1CCN(C(=O)OC(C)(C)C)C2CCc1ccc(C(F)(F)F)cc1.ClC(Cl)(Cl)C(Cl)(Cl)Cl>>CCc1nc(Cl)c2n1CCN(C(=O)OC(C)(C)C)C2CCc1ccc(C(F)(F)F)cc1,,C1CCOC1,,[Li]CCCC,,val
US20110178130A1,CC(C)[C@H]1COCC=CCOc2ccc(cc2)C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)N1>>CC(C)[C@H]1COCCCCOc2ccc(cc2)C[C@@H](N)C(=O)N1,[Pd],CO,,,,val
US20140315917A1,Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.Nc1cc(Br)c(Oc2ccnc(Cl)c2)cc1F>>Cn1cc(-c2cc(Oc3cc(F)c(N)cc3Br)ccn2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20040122007A1,[N-]=[N+]=NC(CO)c1cccc(Br)c1>>NC(CO)c1cccc(Br)c1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20030013705A1,COC(Cl)Cl.O=C(O)C1CCc2ccccc2O1>>O=Cc1ccc2c(c1)CCC(C(=O)O)O2,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US05665883,CC(C)c1cc(C(C)C)c(S(=O)(=O)N=[N+]=[N-])c(C(C)C)c1.COC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>COC(=O)C(=[N+]=[N-])c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20110224190A1,CC(C)N.C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CN(C5CCN(C(=O)c6cc(CO)nc(C(F)(F)F)n6)CC5)C4)c3)ncnc21>>CC(C)NCc1cc(C(=O)N2CCC(N3CC(CC#N)(n4cc(-c5ncnc6[nH]ccc56)cn4)C3)CC2)nc(C(F)(F)F)n1,,ClCCl,,CCN(CC)CC,CS(=O)(=O)Cl,val
US20100130492A1,C1COCCN1.CNc1ncc(-c2nc(N3CCOCC3)c3nc(Cl)n(CC4CC4)c3n2)cn1>>CNc1ncc(-c2nc(N3CCOCC3)c3nc(N4CCOCC4)n(CC4CC4)c3n2)cn1,,CO,ClCCl,CS(C)=O,,val
US20100022611A1,CNOC.Cc1c(C(=O)Cl)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1>>COCNC(=O)c1nn(-c2ccc(Cl)cc2Cl)c(-c2ccc(Cl)cc2)c1C,,ClCCl,,O,c1ccncc1,val
US20070049618A1,CCOc1cc(-c2cccc(C(=O)O)c2)ccc1OC.NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(n1ccnc1)n1ccnc1>>CCOc1cc(-c2cccc(C(=O)NCc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)n2)ccc1OC,,CN(C)C=O,O,CCN(CC)CC,Cl,val
US20020028832A1,CC(C)(C)[Si](Oc1ccc(OCC2CO2)cc1)(c1ccccc1)c1ccccc1.COc1cccc(CCNC(=O)N2CCC(Nc3ccc(CCN)cc3)CC2)c1>>COc1cccc(CCNC(=O)N2CCC(Nc3ccc(CCNC[C@H](O)COc4ccc(O)cc4)cc3)CC2)c1,,CO,ClC(Cl)Cl,O=CO,,val
US20090176778A1,O=C(NCc1cccs1)c1cc2cc(-c3ccccc3)cc(Br)n2n1.O=C1CCC(=O)N1Cl>>O=C(NCc1cccs1)c1nn2c(Br)cc(-c3ccccc3)cc2c1Cl,,CCOC(C)=O,CN(C)C=O,,,val
US20130029971A1,CCO.CCOC(=O)CN1CCN(c2ncc(C(=O)NC3CC3)cc2[N+](=O)[O-])CC1>>CCOC(=O)CC1CCN(c2ncc(C(=O)NC3CC3)cc2N)CC1,[Pd],,,,,val
US05254571,COC(OC)N(C)C.COCC(=O)c1ccccc1>>COc1ccccc1C(=O)C=CN(C)C,,CCOC(C)=O,,CN(C)C=O,,val
US20080275041A1,CCNCC.[O-][n+]1cc(CCl)ccc1Cl>>CCN(CC)Cc1ccc(Cl)[n+]([O-])c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130178486A1,C[C@H](N[S@](=O)C(C)(C)C)c1ccc2[nH]ccc2n1.Cl>>C[C@H](N)c1ccc2[nH]ccc2n1.Cl,,C1COCCO1,CO,,,val
US20110028449A1,CCc1cc(-c2noc(-c3cc(C)cc(CN(C)CC)c3)n2)cc(C)c1O.OCCCBr>>CCc1cc(-c2noc(-c3cc(C)cc(CN(C)CC)c3)n2)cc(C)c1OCCCO,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04075165,C=CCBr.CCC1(C)CC(OC(=O)c2ccccc2)C(C)C(C)(CC)N1>>C=CCN1C(C)(CC)CC(OC(=O)c2ccccc2)C(C)C1(C)CC,,CN(C)C=O,,,,val
US20070049593A1,COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccccc3OCCCl)[nH]c2c1>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCOc1ccccc1-3,,CN(C)C=O,,O,[H-].[Na+],val
US05624942,CNc1cc(Cl)nc(Cl)c1.OCc1ccsc1>>CNc1cc(Cl)nc(OCc2ccsc2)c1,,C1CCOC1,,[H-].[Na+],,val
US20110152523A1,BrCCc1ccc(Br)cc1.COc1ccc([Mg]Br)cc1>>COc1ccc(CCc2ccc(Br)cc2)cc1,,CCCCCC,CCOC(C)=O,C1CCOC1,,val
US20050227953A1,CO.COc1ccc2c(c1)CCC13CNCC1CCC23>>COc1ccc2c(c1)CCC13CN(C)CC1CCC23,,ClCCl,,[NH4+].[OH-],,val
US20070208010A1,CC(C)(C)OC(=O)N[C@H](Cc1cc(F)c(F)cc1F)Cc1nnc2n1CCc1cnc(C(F)(F)F)nc1-2.Cl>>Cl.N[C@H](Cc1cc(F)c(F)cc1F)Cc1nnc2n1CCc1cnc(C(F)(F)F)nc1-2,,C1COCCO1,,,,val
US04801605,C=CC(=O)OC(C)(C)C.COc1cc(O)c(C=O)cc1OC>>COc1cc2c(cc1OC)OCC(C(=O)O)=C2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040058978A1,CC(=O)Nc1cccc(N)c1.CCOC(=C1C(=O)Nc2ccc([N+](=O)[O-])cc21)c1ccccc1>>CC(=O)Nc1cccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)c1,,CN(C)C=O,,,,val
US05057614,Cn1cc(C2=C(c3csc4ccccc34)C(=O)OC2=O)c2ccccc21.N>>Cn1cc(C2=C(c3csc4ccccc34)C(=O)NC2=O)c2ccccc21,,CN(C)C=O,,,,val
US20120069289A1,CC1(C)c2cc(O)ccc2-c2ccc(C#CCCO)cc21>>CC1(C)c2cc(O)ccc2-c2ccc(CCCCO)cc21,,C1CCOC1,,,,val
US05380724,ClCCCBr.O=CN1CCNCC1>>O=CN1CCN(CCCCl)CC1,,Clc1ccccc1,,,,val
US20040006116A1,Cc1oc(-c2ccccc2)nc1CCO.Oc1ccc(Nc2ccccc2)cc1>>Cc1oc(-c2ccccc2)nc1CCOc1ccc(Nc2ccccc2)cc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04621089,CCOC(=O)c1cnc2cn[nH]c2c1Cl.CN(C)C=O>>CCOC(=O)c1cnc2cn(C)nc2c1Cl,,Cc1ccccc1,,,,val
US06248739B1,CCCI.O=C(NCc1ccc(Cl)cc1)c1cnc2ccc(C#CCO)cc2c1O>>CCCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(C#CCO)ccc21,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US04820834,CN1C(=O)C(N)N=C(c2ccccc2)c2ccccc21.Cc1ccc(N=C=O)cc1>>Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1,,C1CCOC1,,,,val
US20110195933A1,CS(=O)(=O)Cl.C[C@@H](N[C@H]1CCCC(F)(F)[C@@H]1O)c1ccccc1>>C[C@@H](N[C@@H]1CCCC(F)(F)[C@H]1OS(C)(=O)=O)c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20150174099A1,CC1(C)OC[C@H]2CC(F)C(=O)N21.O=S(=O)(c1ccccc1)N(F)S(=O)(=O)c1ccccc1>>CC1(C)OC[C@H]2CC(F)(F)C(=O)N21,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20130079320A1,COc1cc(C(C)C(=O)NCc2ccc(C(F)(F)F)nc2N2CCC(C)CC2)ccc1CN.CS(=O)(=O)Cl>>COc1cc(C(C)C(=O)NCc2ccc(C(F)(F)F)nc2N2CCC(C)CC2)ccc1CNS(C)(=O)=O,,ClCCl,c1ccncc1,,,val
US20130029963A1,CS(=O)(=O)c1nncc(-c2ncccn2)n1.N>>Nc1nncc(-c2ncccn2)n1,,C1CCOC1,,,,val
US04906285,CC(C)N.COc1cc(OC)nc(Oc2cccc(Oc3nc(OC)cc(OC)n3)c2C(=O)O)n1>>CC(C)[NH3+].COc1cc(OC)nc(Oc2cccc(Oc3nc(OC)cc(OC)n3)c2C(=O)[O-])n1,,C1CCOC1,,,,val
US20010039344A1,COC(=O)c1ccc(N)nc1.O=C(O)C(CC1CCCC1)c1cccc(Cl)c1>>COC(=O)c1ccc(NC(=O)C(CC2CCCC2)c2cccc(Cl)c2)nc1,CN(C)C=O,ClCCl,,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US06951958B1,CC(C)C=O.c1ccc(CNOCc2ccccc2)cc1>>CC(C)CN(Cc1ccccc1)OCc1ccccc1,,C1CCOC1,CO,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20030212095A1,N#CN1CC2CC(C1)CN(Cc1ccccc1)C2.[N-]=[N+]=[N-].[NH4+]>>[NH4+].c1ccc(CN2CC3CC(C2)CN(c2nn[nH]n2)C3)cc1,,CN(C)C=O,,[Cl-].[Na+],,val
US20140364413A1,O=[N+]([O-])c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1>>Nc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1,[Fe],CC(=O)O,,O,[Na+].[OH-],val
US20090131503A1,CN(C(=O)OC(C)(C)C)C1CCCC(c2c[nH]c3ccc(N)cc23)C1.CSC(=N)c1cccs1>>CN(C(=O)OC(C)(C)C)C1CCCC(c2c[nH]c3ccc(NC(=N)c4cccs4)cc23)C1,,CCO,,I,,val
US20160175284A1,COc1ccc2oc(=O)c(Br)c(C)c2c1>>Cc1c(Br)c(=O)oc2ccc(O)cc12,,ClCCl,,BrB(Br)Br,,val
US20080004258A1,CN.O=Cc1cc(Br)ccc1Oc1ccc(Cl)c(Cl)c1>>CNCc1cc(Br)ccc1Oc1ccc(Cl)c(Cl)c1,,CO,,[BH4-].[Na+],,val
US20150119431A1,CC(C)(C)OC(=O)NN1C[C@H](CO)OC1=O.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)NN1C[C@@H](COS(C)(=O)=O)OC1=O,,ClCCl,,CCN(CC)CC,,val
US07250511B2,CC(=O)Nc1cc2c(cc1Br)C(Nc1ccc(C(=O)OC(C)(C)C)c(F)c1)CC2.N#C[Cu]>>CC(=O)Nc1cc2c(cc1C#N)C(Nc1ccc(C(=O)OC(C)(C)C)c(F)c1)CC2,,CN1CCCC1=O,,N,,val
US20160120850A1,C#CCC(C)(C)C(=O)OC.ON=Cc1nc(CC2CCC2)cs1>>COC(=O)C(C)(C)Cc1cc(-c2nc(CC3CCC3)cs2)no1,,ClCCl,,[Na+].[O-]Cl,,val
US20140121198A1,O=[N+]([O-])c1cnc2ccsc2c1N[C@H]1CCCOC1>>Nc1cnc2ccsc2c1N[C@H]1CCCOC1,[Fe],CCO,,O,[Cl-].[NH4+],val
US06252082B1,COC(=O)Cn1c(C)cc(O)c([N+](=O)[O-])c1=O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)Cn1c(C)cc(OS(=O)(=O)C(F)(F)F)c([N+](=O)[O-])c1=O,,ClCCl,,CCN(CC)CC,,val
US20100184808A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OC[C@@H]1[C@H]2CCC[C@H]2CN1Cc1ccccc1>>CC(C)(C)OC(=O)N1C[C@@H]2CCC[C@@H]2[C@H]1CO,[Pd],CCOC(C)=O,,,,val
US20140066426A1,C/C(=C\c1ccc(Cl)cc1)[N+](=O)[O-].[C-]#[N+]CC(=O)OCC>>CCOC(=O)c1[nH]cc(C)c1-c1ccc(Cl)cc1,,C1CCOC1,CC(C)O,,,val
US20160152613A1,CC(C)(C)OC(=O)Cn1c2c(c(O)cc1=O)C(=O)CC2.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)Cn1c2c(c(OS(=O)(=O)C(F)(F)F)cc1=O)C(=O)CC2,,ClCCl,,CCN(CC)CC,,val
US20080318975A1,CNC.COC(=O)Cc1c(Cl)ccc2ncc(CBr)cc12>>COC(=O)Cc1c(Cl)ccc2ncc(CN(C)C)cc12,,CN(C)C=O,,CCO,,val
US20110021520A1,C[Mg]Br.O=Cc1cc(Br)cc([N+](=O)[O-])c1>>CC(O)c1cc(Br)cc([N+](=O)[O-])c1,Cl[Ti](Cl)(Cl)Cl,C1CCOC1,,,,val
US20100168145A1,COc1ccc(C2(CCO)CC=CC(=O)N2)c(OC)c1>>COc1ccc(C2(CCO)CCCC(=O)N2)c(OC)c1,[Pd],CCO,,,,val
US20110237573A1,Nc1ccc(-c2cnccn2)cn1.O=C(O)Cc1ccc(Br)c(C(F)(F)F)c1>>O=C(Cc1ccc(Br)c(C(F)(F)F)c1)Nc1ccc(-c2cnccn2)cn1,,CCOC(C)=O,CN(C)C=O,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20130065907A1,O=C(Nc1cccnc1)c1cnc(OCC(F)(F)F)c(C2=CCCCC2)c1>>O=C(Nc1cccnc1)c1cnc(OCC(F)(F)F)c(C2CCCCC2)c1,[Pd],CCOC(C)=O,,,,val
US20160075710A1,CC(=O)c1cc(=O)n(Cc2ccccc2)nc1-c1ccccc1>>CC(O)c1cc(=O)n(Cc2ccccc2)nc1-c1ccccc1,,C1CCOC1,CO,O,[BH4-].[Na+],val
US20150299121A1,CC1(C)CC(C(=O)O)C1.Cc1ccc(C(=O)Nc2cc(F)cc(CN3CCN[C@@H](C)C3)c2C)cn1>>Cc1ccc(C(=O)Nc2cc(F)cc(CN3CCN(C(=O)C4CC(C)(C)C4)[C@@H](C)C3)c2C)cn1,,ClCCl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080153850A1,COC(=O)[C@@H](C)Cl.O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(-c2cccc(O)c2)ccc1Cl>>COC(=O)[C@H](C)Oc1cccc(-c2ccc(Cl)c(C(=O)NCC34CC5CC(CC(C5)C3)C4)c2)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080090802A1,CC(C)(C)NC(=O)Cn1c(-c2cccc(Cl)c2)nc2ccc(N3CCCNCC3)cc2c1=O.CC(C)=O>>CC(C)N1CCCN(c2ccc3nc(-c4cccc(Cl)c4)n(CC(=O)NC(C)(C)C)c(=O)c3c2)CC1,,C1CCOC1,,CC(=O)O,[BH3-]C#N.[Na+],val
US06258811B1,ClCCl.O=C(Cl)C(=O)Cl.Oc1cc2c(F)ccc(F)c2o1>>O=Cc1cc2c(F)ccc(F)c2o1,,CCN(CC)CC,O,CS(C)=O,,val
US04173633,COc1ccc2c(c1)CCC(CC#N)C2=O>>COc1ccc2c(c1)CCC1CCN=C21,[Ni],CCO,,[H][H],,val
US20120040991A1,Cc1ccc(-n2ncc(C)n2)c(C(=O)O)n1.FC(F)(F)c1ccc(OC[C@@H]2C[C@H]3C[C@H]3CN2)nc1>>Cc1ccc(-n2nccn2)c(C(=O)N2C[C@@H]3C[C@@H]3C[C@H]2COc2ccc(C(F)(F)F)cn2)n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20100280071A1,CCCO[C@@H]1CC[C@H](N2CCC(Nc3cc(C)ccc3N)CC2)CC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCO[C@@H]1CC[C@H](N2CCC(n3c(=O)[nH]c4ccc(C)cc43)CC2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20060004043A1,FC(F)Cl.N#Cc1ccc2c(c1)c(-c1ccc3cc(O)ccc3c1)nn2C1CCCCO1>>N#Cc1ccc2c(c1)c(-c1ccc3cc(OC(F)F)ccc3c1)nn2C1CCCCO1,,O,,C1CCOC1,[Na+].[OH-],val
US20050085458A1,CC(C)(C)OC(=O)N1CCNCC1.Cc1ccc2c(OCCBr)cccc2n1>>Cc1ccc2c(OCCN3CCN(C(=O)OC(C)(C)C)CC3)cccc2n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060211714A1,COCCBr.O=C(CO)N1CCC[C@@H]1COc1cc(O)cc2ncnc(Nc3ccc(F)c(Cl)c3)c12>>COCCOc1cc(OC[C@H]2CCCN2C(=O)CO)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060194850A1,COC=CC(=O)OC.O/N=C(/Cl)c1ccc(CCl)cc1>>COC(=O)c1conc1-c1ccc(CCl)cc1,,ClCCl,,CCN(CC)CC,O,val
US05217643,CCCCCC1CCC(C(=O)Cl)CC1>>CCCCCC1CCC(CO)CC1,,CCOCC,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20150133422A1,O=C1CCC(n2cc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)cn2)CC1>>O=S(=O)(c1ccccc1)n1cc(-c2cnn([C@@H]3CC[C@@H](O)CC3)c2)c2ccc(F)cc21,,CO,,[BH4-].[Na+],,val
US20100197683A1,CC#N.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(O)CF)CC2)c2ncnn12>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC3(CF)CO3)CC2)c2ncnn12,,CC#N,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20030153753A1,COC(=O)[C@@H](Cc1ccc(C)c(OC)c1)NC(=O)CCl.NCc1ccccc1>>COC(=O)[C@@H](Cc1ccc(C)c(OC)c1)NC(=O)CNCc1ccccc1,,CN(C)C=O,ClCCl,Cl,O=C([O-])[O-].[K+].[K+],val
US05506219,BrC(Br)(Br)Br.CC(C)c1nc(-c2ccccc2)cc(-c2ccc(F)cc2)c1C=O>>CC(C)c1nc(-c2ccccc2)cc(-c2ccc(F)cc2)c1C=C(Br)Br,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070135631A1,CC(C)Oc1ccc([C@](N)(Cc2ccccc2)c2cc(F)cc(OC(F)(F)C(F)F)c2)cc1F.O=C(OC(=O)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)F>>CC(C)Oc1cc([C@@](Cc2ccccc2)(NC(=O)C(F)(F)C(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F,c1ccncc1,ClCCl,,CO,,val
US20070232642A1,C=CCBr.O=C(CC1CCCCC1)N1C(=O)OCC1Cc1ccccc1>>C=CCC(C(=O)N1C(=O)OCC1Cc1ccccc1)C1CCCCC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20040198778A1,CCC(CC(F)(F)F)C(=O)O>>CCC(CO)CC(F)(F)F,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04177274,Nc1ccc(I)cn1.Sc1ccccc1>>Nc1ccc(Sc2ccccc2)cn1,[Cu],CO,,C[O-].[Na+],,val
US20140213554A1,Cc1n[nH]c(C(=O)O)c1C.Nc1cnc2c(c1)cc(I)n2S(=O)(=O)c1ccccc1>>Cc1[nH]nc(C(=O)Nc2cnc3c(c2)cc(I)n3S(=O)(=O)c2ccccc2)c1C,,C1CCOC1,CC#N,CCN(C(C)C)C(C)C,Cl,val
US05464808,COc1cc(OC)nc(N)n1.Nc1ccccc1C(O)C1CC1.O=C=NS(=O)(=O)Cl>>COc1cc(OC)nc(NC(=O)NS(=O)(=O)Nc2ccccc2C(O)C2CC2)n1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20040110787A1,CN(CC(=O)c1cnccn1)Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2s1>>CN(Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2s1)CC(O)c1cnccn1,,CO,,[BH4-].[Na+],,val
US20120208797A1,CC(C)(C)OC(=O)N1CCCC(O)C1.Cn1c(Cl)nc(-c2ccncn2)cc1=O>>Cn1c(OC2CCCNC2)nc(-c2ccncn2)cc1=O,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20130158025A1,Cc1cc2nc(Cl)cc(-c3ccc(F)c(F)c3)n2n1.O=C1CCC(=O)N1I>>Cc1nn2c(-c3ccc(F)c(F)c3)cc(Cl)nc2c1I,,ClCCl,,,,val
US20070275987A1,CCc1cnc(Cl)c(C(=O)NC(=N)COCCc2cccc(Cl)c2)c1>>CCc1cnc2nc(COCCc3cccc(Cl)c3)[nH]c(=O)c2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090170913A1,CN1CCC(CN(C)c2nc3cc(N)ccc3o2)C1.O=C(O)c1ccc(-c2ccc(F)cc2)cc1>>CN1CCC(CN(C)c2nc3cc(NC(=O)c4ccc(-c5ccc(F)cc5)cc4)ccc3o2)C1,,ClCCl,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20060128732A1,BrCCn1cccc1.O=C(NC1=Nc2cc(O)ccc2C2=NCCN12)c1cccnc1>>O=C(NC1=Nc2cc(OCCn3cccc3)ccc2C2=NCCN12)c1cccnc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140343032A1,CN(C)C(OC(C)(C)C)N(C)C.NN.O=C1CC2COCC(C1)N2S(=O)(=O)c1ccccc1[N+](=O)[O-]>>O=[N+]([O-])c1ccccc1S(=O)(=O)N1C2COCC1c1cn[nH]c1C2,,C1COCCO1,,O,,val
US20090275588A1,COc1ccc(S(=O)(=O)Nc2cc(C=O)ccc2Cl)cc1OC.[Li]C>>COc1ccc(S(=O)(=O)Nc2cc(C(C)O)ccc2Cl)cc1OC,,C1CCOC1,,CCOCC,,val
US20160052888A1,CC(C)(C)OC(=O)N[C@]1(CO)CC[C@H](c2ccc3c(c2)CCC(O)C3)C1.COC(C)(C)OC>>CC(C)(C)OC(=O)N1C(C)(C)OC[C@]12CC[C@H](c1ccc3c(c1)CCC(O)C3)C2,,CC(C)=O,,CCOCC,FB(F)F,val
US20120252815A1,CC1(C)CCC(C)(C)c2cc(-c3csc(CC#N)n3)ccc21>>CC1(C)CCC(C)(C)c2cc(-c3csc(CCN)n3)ccc21,,C1CCOC1,CO,Cl,,val
US05811459,COC(=O)c1ccc(CCCc2ncccc2OCc2ccccc2)cc1>>O=C(O)c1ccc(CCCc2ncccc2OCc2ccccc2)cc1,,CCO,,Cl,[Na+].[OH-],val
US20040127574A1,O=C(OCc1ccccc1)C(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1ccc(Oc2ccccn2)cc1>>O=C(O)C(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1ccc(Oc2ccccn2)cc1,[Pd],CCO,,[H][H],,val
US20120088755A1,Cc1nc2c(C(F)(F)F)cc(Oc3cc(Cl)ncn3)cc2[nH]1.O=C1Nc2ncccc2C2(CCNCC2)O1>>Cc1nc2c(C)cc(Oc3cc(N4CCC5(CC4)OC(=O)Nc4ncccc45)ncn3)cc2[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20070066618A1,CC(C)(C)OC(=O)NOC(=O)OC(C)(C)C.CCc1nc2cc(Cl)c(Cl)cc2n1-c1ccc(CCO)cc1>>CCc1nc2cc(Cl)c(Cl)cc2n1-c1ccc(CCN(OC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070213359A1,CC(=O)Cl.c1cnc2[nH]ccc2c1>>CC(=O)c1c[nH]c2ncccc12,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20070043063A1,CC(C)OB(OC(C)C)OC(C)C.COc1cc(Br)ccc1C#N>>COc1cc(B(O)O)ccc1C#N,,C1CCOC1,O,Cl,[Li]CCCC,val
US20100125081A1,Cc1cc(C2(c3ccnc(Cl)c3)N=C(N)c3ncccc32)cc(C2CC2)c1OC(F)F.OB(O)c1cncnc1>>Cc1cc(C2(c3ccnc(-c4cncnc4)c3)N=C(N)c3ncccc32)cc(C2CC2)c1OC(F)F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20070049618A1,NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1cccc(C(F)(F)F)c1F>>O=C1CCC(N2C(=O)c3cccc(CNC(=O)c4cccc(C(F)(F)F)c4F)c3C2=O)C(=O)N1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US05352388,C1CCNCC1.O=C(O)c1ccc(O)cc1>>C1CC[NH2+]CC1.O=C([O-])c1ccc(O)cc1,,CCO,,,,val
US20160000760A1,CCCC(=O)Nc1ccc(-c2ccc([N+](=O)[O-])cc2)cc1.CO>>CCCCC(=O)Nc1ccc(-c2ccc(N)cc2)cc1,[Fe],,,O,[Cl-].[NH4+],val
US20110136871A1,CCCO.N#Cc1c(Cl)nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1ccccc1>>CCCOc1nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c(-c2ccccc2)c1C#N,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20110112158A1,Cc1ccc2onc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c2c1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1noc2ccc(CBr)cc12,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US06046201,CC(C)(C)OC(=O)NCCCCCCCCCCCCO.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)NCCCCCCCCCCCCOS(C)(=O)=O,,C1CCOC1,,CCN(CC)CC,CCOC(C)=O,val
US20130281434A1,Cc1cc2nc(-c3cccc(-c4ccc5c(cnn5C)c4)c3)sc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C>>Cc1cc2nc(-c3cccc(-c4ccc5c(cnn5C)c4)c3)sc2c(-c2ccc(Cl)cc2)c1[C@@H](CO)OC(C)(C)C,,C1CCOC1,CO,CCOC(C)=O,[Na+].[OH-],val
US20040082542A1,O=[N+]([O-])c1ccc(Oc2ccc(-c3ccccc3)cc2)cc1>>Nc1ccc(Oc2ccc(-c3ccccc3)cc2)cc1,[Pd],CCOC(C)=O,,,,val
US20050245503A1,NNc1ncc(C(=O)O)cc1Cl.S=C=NC1c2ccccc2CSc2ccccc21>>O=C(O)c1cnc(NNC(=S)NC2c3ccccc3CSc3ccccc32)c(Cl)c1,,CC(=O)N(C)C,,,,val
US06093345,CCCC[C@H](C)C[C@@H](OC1CCCCO1)C(=O)OC>>CCCC[C@H](C)C[C@H](CO)OC1CCCCO1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120329785A1,CN1CCCc2cc(N)ccc21.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1>>COc1ccc2nc(Nc3ccc4c(c3)CCCN4C)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US20080167307A1,CCOC(=O)C(C)(C)Sc1nc(CCOCc2ccc(Br)cc2)cs1.OB(O)Oc1ccc(F)cc1>>CCOC(=O)C(C)(C)Sc1nc(CCOCc2ccc(-c3ccc(F)cc3)cc2)cs1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20060183743A1,COc1ccc2c(c1)CSC(C(=O)O)C2.O=C(Cl)C(=O)Cl>>COc1ccc2c(c1)CSC(C(=O)Cl)C2,,ClCCl,,CN(C)C=O,,val
US20130035318A1,C=C(C)[C@@H]1CC[C@]2(NCCCN3CCS(=O)(=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)O)c(C)c6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(NCCCN3CCS(=O)(=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1COCCO1,,[Na+].[OH-],,val
US20040034017A1,C1CCNCC1.CCOC(C)=O.Oc1ccc(C2=C(C(F)(F)F)c3ccc(O)cc3OC2c2ccc(OCCCCl)cc2)cc1>>Oc1ccc(C2=C(C(F)(F)F)c3ccc(O)cc3OC2c2ccc(OCCCCN3CCCCC3)cc2)cc1,,CCOC(C)=O,CN1CCCC1=O,[I-].[K+],,val
US20100254942A1,Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.O=C(O)c1ccc2c(Br)cccc2c1>>Cn1cc(-c2cccc3cc(C(=O)O)ccc23)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,,,val
US07135467B2,CCOC(=O)c1nc(N2CCCCS2(=O)=O)n(C)c(=O)c1O.NCc1ccc(F)cc1>>Cn1c(N2CCCCS2(=O)=O)nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O,,CN(C)C=O,,CCO,,val
US20160250216A1,Nc1nnn[nH]1.O=C(/C=C/c1cccc(Br)c1)c1cc(F)cc(Br)c1>>Fc1cc(Br)cc(C2=CC(c3cccc(Br)c3)n3nnnc3N2)c1,,CN(C)C=O,ClCCl,O,,val
US20120309735A1,CCOC(=O)C1CCN(c2nc(-c3cccc(N)c3)cs2)CC1.FC(F)(F)c1ccnc(Cl)n1>>CCOC(=O)C1CCN(c2nc(-c3cccc(Nc4nccc(C(F)(F)F)n4)c3)cs2)CC1,,C1COCCO1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150031689A1,CC(C)(C)NC(=O)C1(c2ccccc2)CCNCC1.Clc1ccc(-n2c(-c3ccccc3Cl)nc3c(Cl)ncnc32)cc1>>CC(C)(C)NC(=O)C1(c2ccccc2)CCN(c2ncnc3c2nc(-c2ccccc2Cl)n3-c2ccc(Cl)cc2)CC1,,CCO,,CCN(CC)CC,,val
US20060111305A1,C=CCO.O=c1oc(=O)c2ccccc2c2ccccc12>>C=CCOC(=O)c1ccccc1-c1ccccc1C(=O)O,CN(C)c1ccncc1,,,,,val
US04608383,Cc1c(NCCN)n(C)c(=O)n(C)c1=O.Fc1ccc(OCC2CO2)cc1.O=C(O)/C=C/C(=O)O>>Cc1c(NCCNCC(COc2ccc(F)cc2)OC(=O)/C=C/C(=O)O)n(C)c(=O)n(C)c1=O,,CCO,CCOC(C)=O,CN(C)C=O,,val
US20150329538A1,ON=C1CCCc2[nH]c(Br)cc21>>O=C1NCCCc2[nH]c(Br)cc21,,C1CCOC1,CCOC(C)=O,O=S(Cl)Cl,,val
US20100305096A1,CC(C)(O)C(=O)O.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CNC3)sc2n1>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CN(C(=O)C(C)(C)O)C3)sc2n1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050059650A1,O=C(O)c1c[nH]c2c(I)cccc2c1=O>>O=c1cc[nH]c2c(I)cccc12,,c1ccc(Oc2ccccc2)cc1,,,,val
US05624935,COC(=O)C1Cc2ccccc2N1C>>CN1c2ccccc2CC1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160122335A1,C[Si](C)(C)C(F)(F)F.Cc1cc(C(=O)C(F)(F)F)ccc1Br>>Cc1cc(C(O)(C(F)(F)F)C(F)(F)F)ccc1Br,,C1CCOC1,,Cl,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20100221269A1,CC(C)CCCCCCCCC[C@H](CC(=O)OCC(=O)c1ccc(Br)cc1)OCc1ccccc1>>CC(C)CCCCCCCCC[C@H](CC(=O)O)OCc1ccccc1,[Zn],CC(=O)O,ClCCl,,,val
US20090124802A1,Nc1cc(O)nc(N)n1.O=CCCl>>Nc1nc2[nH]ccc2c(=O)[nH]1,,O,,CC(=O)[O-].[Na+],,val
US20140221311A1,C[C@H](N)C(F)(F)F.Nc1ncc(-c2ccc(-c3ccccc3C(=O)O)cc2F)cn1>>C[C@H](NC(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)c(F)c1)C(F)(F)F,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130190325A1,COc1cc(OC)c(C=O)c(OC)c1.COc1ccc(CS(=O)(=O)CC(=O)O)nc1[N+](=O)[O-]>>COc1cc(OC)c(/C=C/S(=O)(=O)Cc2ccc(OC)c([N+](=O)[O-])n2)c(OC)c1,,Cc1ccccc1,,CC(=O)OC(C)=O,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3ccncc3)c2)=C(C)C1=O.CS(=O)(=O)O>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3ccncc3)c2)=C(C)C1=O.CS(=O)(=O)O,,ClCCl,,CO,,val
US20160083400A1,Cc1cccc(C(CCn2c(Cl)nn3c(C4CCOCC4)ncc3c2=O)N(C(=O)[O-])C(C)(C)C)c1>>Cc1cccc(C(N)CCn2c(Cl)nn3c(C4CCOCC4)ncc3c2=O)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050124654A1,C1CCOC1.CC(C)(C)OC(=O)NC1CCCc2cc(C=O)ccc21.CCOP(=O)(C#N)OCC>>CC(C)(C)OC(=O)NC1CCCc2cc(C=CC#N)ccc21,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20060166963A1,CC(C)(C)C(=O)OC(=O)C(C)(C)C.Cc1ccc2c(=O)[nH]c(-c3ccccc3O)nc2c1>>Cc1ccc2c(=O)[nH]c(-c3ccccc3OC(=O)C(C)(C)C)nc2c1,,CN(C)C=O,,O,c1ccncc1,val
US20130072473A1,CC(=O)Nc1sc2c(c1C(=O)Nc1ccccc1)CCN(C(=O)OC(C)(C)C)C2.O=C(O)C(F)(F)F>>CC(=O)Nc1sc2c(c1C(=O)Nc1ccccc1)CC[NH2+]C2.O=C([O-])C(F)(F)F,,ClCCl,,,,val
US04824470,CC(=O)C1=C(O)CC(C2CCCSC2)CC1=O.NOCc1ccc(Cl)s1>>CC(=NOCc1ccc(Cl)s1)C1=C(O)CC(C2CCCSC2)CC1=O,,CCO,,,,val
US20040122098A1,COC(=O)C(O)[C@@H](CCSC)NC(=O)OC(C)(C)C>>COC(=O)C(O)[C@H](N)CCSC,,C1COCCO1,Cl,,,val
US05958918,CC(C)(C)OC(=O)N[C@H]1CCNC1=O.N#Cc1cc(CBr)cs1>>CC(C)(C)OC(=O)NC1CCN(Cc2csc(C#N)c2)C1=O,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20160158207A1,CC(C)C=O.NNc1ccc(Br)cc1>>CC1(C)CNc2ccc(Br)cc21,,CC(=O)O,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140107097A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(c1cccnc1)C1CCNCC1>>CC(C)(C)OC(=O)N1CCC(C(=O)c2cccnc2)CC1,CN(C)c1ccncc1,C1CCOC1,ClCCl,CCN(CC)CC,Cl,val
US04701459,CCOC(=O)C1CCN(c2ccc([N+](=O)[O-])c(C=C3NC(=O)NC3=O)c2)CC1>>COC(=O)C1CCN(c2ccc3nc4[nH]c(=O)[nH]c4cc3c2)CC1,[Pd],CN(C)C=O,,,,val
US06566381B1,C=CCN(CC(=O)OC)C(=O)OC(C)(C)C.O=S(=O)(Cl)c1ccc(-c2ccccc2)cc1>>C=CCC(NS(=O)(=O)c1ccc(-c2ccccc2)cc1)C(=O)OC,,ClCCl,O,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20120083475A1,CCOCC1CC(C(=O)OCC)=NO1>>CCOCC1CC(C(=O)O)=NO1,,CCO,,Cl,[Na+].[OH-],val
US20080261941A1,C#CCCCOc1ccc(Oc2cccc(C=C3CCNCC3)c2)nc1.O=C(Nc1cccnn1)Oc1ccccc1>>C#CCCCOc1ccc(Oc2cccc(C=C3CCN(C(=O)Nc4cccnn4)CC3)c2)nc1,,CS(C)=O,O,CCN(CC)CC,,val
US20100160424A1,COC(=O)NCCOC(c1cc(F)cc(Cl)c1)c1cccc(C(=O)NCC(CC2CCCOC2)N(C)C(=O)OC(C)(C)C)c1>>CN[C@H](CNC(=O)c1cccc([C@@H](OCCNC(=O)OC)c2cc(F)cc(Cl)c2)c1)C[C@H]1CCCOC1,,C1COCCO1,Cl,,,val
US20070197512A1,CC(C)c1cccc2c1OC(C(C)C)CN2.COC(=O)C(=O)Cl>>COC(=O)C(=O)N1CC(C(C)C)Oc2c(C(C)C)cccc21,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20160039844A1,C=CCCc1ccccc1C#N>>C=CCCc1ccccc1CN,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05288428,CI.OC/C=C/[C@@H]1CC[C@@H](c2ccc(Br)cc2)CC1>>COC/C=C/[C@@H]1CC[C@@H](c2ccc(Br)cc2)CC1,,O,,C1CCOC1,[H-].[Na+],val
US20160194328A1,Nc1ncnc2c1nc(Sc1cc(Cl)cc(Cl)c1)n2CCCN1C(=O)c2ccccc2C1=O>>NCCCn1c(Sc2cc(Cl)cc(Cl)c2)nc2c(N)ncnc21,,ClCCl,,NN,O,val
US06441017B1,COC(=O)C=Cc1c[nH]cn1.Cl>>COC(=O)CCc1c[nH]cn1.Cl,[Pd],CCO,,,,val
US05455273,CNCc1cc(C(=O)OC(C)(C)C)ccc1[C@@H]1CC[C@@H](NC)CC1.O=C(Cl)c1ccc(Cl)cc1>>CNCc1cc(C(=O)OC(C)(C)C)ccc1[C@@H]1CC[C@@H](N(C)C(=O)c2ccc(Cl)cc2)CC1,,CCOCC,,CCN(CC)CC,,val
US20150133457A1,CC(=O)N1CC[C@H](Nc2ccc([N+](=O)[O-])cc2)C1>>CC(=O)N1CC[C@H](Nc2ccc(N)cc2)C1,[Pd],,,[H][H],,val
US20090291079A1,NCc1ccccn1.O=C(Nc1ccc(C(=O)O)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1>>O=C(Nc1ccc(C(=O)Cc2ccccn2)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04426321,C=CC(C)=CCCl.CCC(=O)CC>>C=CC(C)=CCC(C)C(=O)CC,,CCCCC,,[K+].[OH-],,val
US20140200227A1,CC(=O)OC1CCc2c1ncc(N)c2N1C[C@H](C(F)(F)F)C[C@H](NC(=O)OC(C)(C)C)C1.CC(C)(O)c1cc(F)c(-c2nc(C(=O)O)ccc2F)c(F)c1>>CC(=O)OC1CCc2c1ncc(NC(=O)c1ccc(F)c(-c3c(F)cc(C(C)(C)O)cc3F)n1)c2N1C[C@H](C(F)(F)F)C[C@H](NC(=O)OC(C)(C)C)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06130239,CCOC(=O)c1c[nH]c(/C=C2\C(=O)Nc3ccc(F)c(C#C[C@@H]4CCCN4)c32)c1C.Cl>>CCOC(=O)c1c[nH]c(/C=C2\C(=O)Nc3ccc(F)c(C#C[C@@H]4CCCN4)c32)c1C.Cl,,C1COCCO1,,,,val
US20120094972A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1c(Nc2ccccn2)nc2cc(F)cc(F)c2c1Cl>>Cc1c(N(C(=O)OC(C)(C)C)c2ccccn2)nc2cc(F)cc(F)c2c1Cl,CN(C)c1ccncc1,CN(C)C=O,ClCCl,CCN(CC)CC,,val
US04772630,CCN(CC)CCN.COc1cc(Cl)c(C#N)cc1C(=O)Cl>>CCN(CC)CCNC(=O)c1cc(C#N)c(Cl)cc1OC,,ClCCl,,[Na+].[OH-],,val
US20120322784A1,C#CC1CCN(C(=O)OC(C)(C)C)CC1.Oc1ccc(Cl)nc1I>>CC(C)(C)OC(=O)N1CCC(c2cc3nc(Cl)ccc3o2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,CCN(CC)CC,,val
US20100087429A1,COc1ccc2c(c1)C1(N=C(N)OC1C)c1cc(Br)ccc1O2.OB(O)c1cncnc1>>COc1ccc2c(c1)[C@]1(N=C(N)O[C@H]1C)c1cc(-c3cncnc3)ccc1O2,,CCOC(C)=O,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20160237090A1,C[C@H]1Cn2ncc(C3CCNC3=O)c2CN1.O=C(Nc1cc(F)c(F)c(F)c1)Oc1ccccc1>>C[C@H]1Cn2ncc(C3CCNC3=O)c2CN1C(=O)Nc1cc(F)c(F)c(F)c1,,CN(C)C=O,,CCN(CC)CC,,val
US20080207654A1,CCCCc1nc(CCc2ccccc2)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCCc1nc(CCc2ccccc2)[nH]c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20020107280A1,CS(=O)(=O)c1ccc(C=O)cc1.O=C(O)CC(=O)O>>CS(=O)(=O)c1ccc(C=CC(=O)O)cc1,,CCO,c1ccncc1,,,val
US05981533,CC(=O)Nc1ccc(Nc2n[nH]c(N)c2C#N)cc1.CCOC(OCC)N(C)C>>CC(=O)Nc1ccc(Nc2n[nH]c(N=CN(C)C)c2C#N)cc1,,Cc1ccccc1,,,,val
US20100168145A1,CCOC(=O)Cl.N#Cc1ccc(C2CCCc3cncn32)cc1>>CCOC(=O)C1(c2ccc(C#N)cc2)CCCc2cncn21,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20130150343A1,C[C@H]1COCCN1.NC(=O)Cl.NNc1ccc(F)cn1>>C[C@H]1COCCN1C(=O)N(N)c1ccc(F)cn1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04339386,CN=C=O.COc1ccc(-c2ccc(C=NO)o2)cc1OC>>CNC(=O)ON=Cc1ccc(-c2ccc(OC)c(OC)c2)o1,,O,,CN(C)C=O,,val
US20080139631A1,N#Cc1ccc(N=C(c2ccccc2)c2ccccc2)c(CBr)c1C(F)(F)F>>N#Cc1ccc(N)c(CBr)c1C(F)(F)F,,C1CCOC1,,Cl,,val
US05360811,CCCCCCCCCCC#Cc1csc(CC(NC(C)=O)(C(=O)OCC)C(=O)OCC)c1>>CCCCCCCCCCC#Cc1csc(CC(CO)NC(C)=O)c1,,C1CCOC1,,[BH4-].[Li+],,val
US05750549,C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(Cl)C(=O)Cl>>C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)Cl)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,ClCCl,,CN(C)C=O,,val
US06703082B1,BrCc1ccc2cc(OCc3ccccc3)ccc2c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>[Br-].c1ccc(COc2ccc3cc(C[P+](c4ccccc4)(c4ccccc4)c4ccccc4)ccc3c2)cc1,,CN(C)C=O,,,,val
US20090137610A1,COc1cccc(C2=CCC3(CC2)OCCO3)c1>>COc1cccc(C2CCC3(CC2)OCCO3)c1,[Pd],CCOC(C)=O,,,,val
US20140088080A1,CC(C)(C)OC(=O)N[C@H](c1ccccc1)[C@H](O)CO[Si](C)(C)C(C)(C)C.Cl>>Cl.N[C@H](c1ccccc1)[C@H](O)CO,,CO,,C1COCCO1,,val
US20140275179A1,CCOC(=O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)c(F)c1>>OCCCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)c(F)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20020035134A1,COc1ccc([N+](=O)[O-])cc1C(F)(F)F.N#CC(Cl)Oc1ccccc1>>COc1cc(CC#N)c([N+](=O)[O-])cc1C(F)(F)F,,CN(C)C=O,,Cl,CC(C)(C)[O-].[K+],val
US20110046093A1,CCOC(=O)C(C)(C)CN(c1nc(Cl)ncc1[N+](=O)[O-])C1CCCC1>>CCOC(=O)C(C)(C)CN(c1nc(Cl)ncc1N)C1CCCC1,[Fe],CCO,,[Cl-].[NH4+],,val
US20140023603A1,COc1cc(C=O)cc(OC)c1O.O=C1CNC(=O)N1>>COc1cc(/C=C2\NC(=O)NC2=O)cc(OC)c1O,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20100093724A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC[C@H](N)c1ccnc(S(C)(=O)=O)c1>>CC[C@H](NC(=O)OC(C)(C)C)c1ccnc(S(C)(=O)=O)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20160159774A1,CC(C)(C)OC(=O)N1CCc2cc(N)ccc2C1.COc1ccc(CCl)cc1>>COc1ccc(CNc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04883789,C=CCc1ccc(F)c(Oc2ccccc2)c1.C[SiH](C)Cl>>C[Si](C)(Cl)CCCc1ccc(F)c(Oc2ccccc2)c1,,C1CCOC1,,,,val
US20090215725A1,CC#CCOCC1CCC2(CC1)OCCO2>>CC#CCOCC1CCC(=O)CC1,,CC(C)=O,,Cl,,val
US03936439,CC(=O)OC(C)=O.OC[C@H]1O[C@@H](n2cnc3c(O)nc(Nc4ccccc4)nc32)[C@H](O)[C@@H]1O.c1ccncc1>>CC(=O)OC[C@H]1O[C@@H](n2cnc3c(O)nc(Nc4ccccc4)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O,,c1ccncc1,,,,val
US04377576,CCC1CCCCN1.CN1C(=O)c2ccccc2N(C(=O)CCCl)c2ccccc21>>CCC1CCCCN1CCC(=O)N1c2ccccc2C(=O)N(C)c2ccccc21.Cl,,CCCO,,,,val
US20030092712A1,CC1CN(C(=O)OC(C)(C)C)CCN1.O=Cc1cc(-c2ccccc2Cl)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)NC2>>CC1CN(C(=O)OC(C)(C)C)CCN1Cc1cc(-c2ccccc2Cl)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)NC2,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20130267546A1,CCCCCCCCCCCCCCCBr.Cc1nc(-n2c(C)ccc2C)nc(C)c1OCc1ccccc1>>CCCCCCCCCCCCCCCCc1nc(-n2c(C)ccc2C)nc(C)c1OCc1ccccc1,,C1CCOC1,CCCCC,[Li]CCCC,,val
US20080261941A1,CC(C)(C)OC(=O)N1CCC(=Cc2cccc(Oc3ccc(Br)cn3)c2)CC1.O=C(O)C(F)(F)F>>Brc1ccc(Oc2cccc(C=C3CCNCC3)c2)nc1.O=C(O)C(F)(F)F,,ClCCl,,Cc1ccccc1,,val
US20090203750A1,CCOC(=O)[C@@H]1C[C@H]1c1cccc(Br)c1.OB(O)c1ccc(Cl)cc1>>CCOC(=O)[C@@H]1C[C@H]1c1cccc(-c2ccc(Cl)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20150175601A1,CC(C)(C)OC(=O)N1CCC(O)C(F)C1.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])cc2)C(F)C1,,CC(=O)N(C)C,,[H-].[Na+],,val
US04523030,COC(=O)C1=Cc2cc(C(=O)c3ccccc3F)c(OC)cc21>>COC(=O)C1=Cc2cc(C(=O)c3ccccc3F)c(O)cc21,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20140249143A1,CCOC(=O)CC(=O)C(C)C.Nc1cccc(N)n1>>CC(C)c1cc(=O)c2ccc(N)nc2[nH]1,,c1ccc(Oc2ccccc2)cc1,,,,val
US20040220185A1,NO.O=S(=O)(C=CCCCc1ncccn1)N1CCN(c2ccc(C#Cc3ccc(F)cc3)cn2)CC1>>O=S(=O)(CC(CCCc1ncccn1)NO)N1CCN(c2ccc(C#Cc3ccc(F)cc3)cn2)CC1,,C1CCOC1,,,,val
US20110218197A1,BrBr.CCOC(=O)c1cc(C(C)(C)C)nn1C>>CCOC(=O)c1c(Br)c(C(C)(C)C)nn1C,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20110207781A1,CON=Cc1cc(Cl)c(OC[C@@H]2CCCN2)c(Cl)c1.Cn1cc(C(=O)Cl)c(C(F)F)n1>>CON=Cc1cc(Cl)c(OC[C@@H]2CCCN2C(=O)c2cn(C)nc2C(F)F)c(Cl)c1,,ClCCl,,CCN(CC)CC,,val
US20120064181A1,Cc1ccc(-c2cc(C(=O)OC(C)(C)C)cc3nccn23)cc1>>Cc1ccc(-c2cc(C(=O)O)cc3nccn23)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140031368A1,CC(C)(C)OC(=O)C(C(=O)OC(C)(C)C)c1ccc(N)cc1.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)C(C(=O)OC(C)(C)C)c1ccc(NC(=O)OCc2ccccc2)cc1,,O,,ClCCl,O=C([O-])O.[Na+],val
US20120244171A1,CC1(C)CS1.OCc1cc(CO)cc(CS)c1>>CC(C)(S)CSCc1cc(CO)cc(CO)c1,,CO,,CCN(CC)CC,,val
US20020120130A1,O=C(OC[C@@H]1O[C@H](n2cc(F)c(=O)[nH]c2=O)C[C@@H]1OC(=O)c1ccccc1)c1ccccc1>>O=c1[nH]c(=O)n([C@@H]2C[C@H](O)[C@H](CO)O2)cc1F,,CO,O,,,val
US20020052400A1,CCOC(=O)C(Br)CBr.Oc1ccccc1O>>CCOC(=O)C1COc2ccccc2O1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06777428B1,COc1cccc(C(=O)C2CCN(C)CC2)c1>>CN1CCC(C(=O)c2cccc(O)c2)CC1,,Br,,,,val
US20140031342A1,Cc1ccc(S(=O)(=O)OCCC2CCN(C(=O)OC(C)(C)C)CC2)cc1.Oc1ccc(OC(F)(F)F)cc1>>CC(C)(C)OC(=O)N1CCC(CCOc2ccc(OC(F)(F)F)cc2)CC1,,O,,CN(C)C=O,[H-].[Na+],val
US20040106645A1,CCOC(=O)N1CCC(N)C(C)(C)C1.O=c1cc(OS(=O)(=O)C(F)(F)F)c2cc(Cl)ccc2o1>>CCOC(=O)N1CCC(Nc2cc(=O)oc3ccc(Cl)cc23)C(C)(C)C1,,CN(C)C=O,,[H-].[Na+],,val
US05006549,CCOC(=O)c1oc2cccc(O)c2c1C.CI>>CCOC(=O)c1oc2cccc(OC)c2c1C,,CC(C)=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20140179695A1,CC(C)(C)OC(=O)NC1=NC2(CO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1OC(C)(C)C21COC1>>CC1(C)Oc2ccc(NC(=O)c3ccc(Cl)cn3)cc2C2(COC(N)=N2)C12COC2,,Cc1ccccc1,,,,val
US20140357512A1,BrCCCCCBr.N#CCc1cccc(F)c1>>N#CC1(c2cccc(F)c2)CCCCC1,,CN(C)C=O,,[H-].[Na+],,val
US20080255078A1,C=CC(=O)OCC.CCC(=O)c1cccc(Br)c1>>CCOC(=O)/C=C/c1cccc(C(=O)CC)c1,,CN(C)C=O,,CCN(CC)CC,,val
US20150284344A1,COc1cc(Oc2ccc(Cl)cc2)ccc1C(=O)Cn1cncn1>>COc1cc(Oc2ccc(Cl)cc2)ccc1C(O)Cn1cncn1,,CO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20120157448A1,CC1(CCO)CC(=O)c2cc(Br)ccc2O1.COCCl>>COCOCCC1(C)CC(=O)c2cc(Br)ccc2O1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020045758A1,C=CS(=O)(=O)CC.CS(=O)c1c(C=NO)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N>>CCS(=O)(=O)CCON=Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1S(C)=O,,CCO,,C,C[O-].[Na+],val
US05594144,CC(C)c1ccc(C=O)c(=O)c(O)c1.[Li]C>>CC(C)c1ccc(C(C)O)c(=O)c(O)c1,,C1CCOC1,,CCOCC,,val
US20040063739A1,C/C=C/C=O.Cl.Nc1ccc(Cl)cc1.[Cl-].[Cl-].[Zn+2]>>Cc1ccc2cc(Cl)ccc2n1.Cl.[Cl-].[Cl-].[Zn+2],,CCCCO,,,,val
US20020019371A1,CCOC(=O)Cc1cccc(N)c1.O=CO>>CCOC(=O)Cc1cccc(NC=O)c1,,CC(C)OC(C)C,,,,val
US20040204448A1,CCOc1cc(C(CC(=O)O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC(F)F.CNC>>CCOc1cc(C(CC(=O)N(C)C)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC(F)F,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20140275316A1,C=CC(=O)OC.CC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1>>COC(=O)CCC(C)c1cccc(C(=O)c2ccccc2)c1,,[Na+],[OH-],CC#N,,val
US20130172323A1,CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OC(C)C(OC)OC)cc3)oc2c1>>CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OC(C)C=O)cc3)oc2c1,,C1COCCO1,,Cl,,val
US05834506,CC(C)(C)[Si](C)(C)OCCOc1ccc(C2(CCc3ccccc3)CC(O)=CC(=O)O2)cc1.Cc1ccc(S(=O)(=O)Sc2cc(C)c(O[Si](C)(C)C(C)(C)C)cc2C(C)(C)C)cc1>>Cc1cc(SC2=C(O)CC(CCc3ccccc3)(c3ccc(OCCO)cc3)OC2=O)c(C(C)(C)C)cc1O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110152297A1,COC(=O)[C@@H]1C[C@H](Oc2cc3c(Cl)ncnc3cc2OC)CCN1C(=O)OC(C)(C)C.Nc1cccc(Cl)c1F>>COC(=O)[C@@H]1C[C@H](Oc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)CCN1,,C1COCCO1,CC#N,Cl,,val
US20120010183A1,FC(F)(F)c1cccnc1Cl.OCC(F)(F)C(F)F>>FC(F)C(F)(F)COc1ncccc1C(F)(F)F,,C1CCOC1,,[H-].[Na+],,val
US20090091243A1,CCCc1cc(F)c2cc(C)c(C)nc2c1C#CCO>>C#Cc1c(CCC)cc(F)c2cccnc12,,CCOCC,,Cc1ccccc1,[Na+].[OH-],val
US20160022640A1,Cc1cc(O)[nH]n1.O=C1c2ccccc2C(=O)N1CCBr>>Cc1cc(O)n(CCN2C(=O)c3ccccc3C2=O)n1,,C1COCCO1,,,,val
US20090209755A1,Brc1cccc(C2=CCOCC2)c1.O=C(OO)c1cccc(Cl)c1>>Brc1cccc(C23CCOCC2O3)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US20070161685A1,FC(F)(F)[C@@H]1CO1.N[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1>>O[C@H](CN[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1)C(F)(F)F,,CC#N,,,,val
US20100267708A1,CCOC(=O)CC[C@@H]1CSC(c2cc3cc(C)cc(NC4CCCC4)c3[nH]2)=N1>>Cc1cc(NC2CCCC2)c2[nH]c(C3=N[C@H](CCC(=O)O)CS3)cc2c1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US07495007B2,C#CC1CC1.CCN(CC)CC.CN(C)C=O.O=C1CC(c2cccc(Cl)c2)C2(C(=O)Nc3cc(Cl)ccc32)C(c2cc(I)ccc2OCCO)N1>>CC(C#Cc1ccc(OCCO)c(C2NC(=O)CC(c3cccc(Cl)c3)C23C(=O)Nc2cc(Cl)ccc23)c1)C1CC1,[Cu]I,,,,,val
US20140235620A1,CC1(C)COC(=O)N1.Clc1cc(Cl)nc(Cl)n1>>CC1(C)COC(=O)N1c1cc(Cl)nc(Cl)n1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20110021489A1,CCc1ccc(C2CC(c3nc(N)no3)CN(C(=O)N3CCC(O)CC3)C2)cc1.Cl>>CCc1ccc(C2CC(c3nc(Cl)no3)CN(C(=O)N3CCC(O)CC3)C2)cc1,,O,,O=N[O-].[Na+],,val
US20110135668A1,COc1ccc(Cn2nnc3c(Nc4ccccc4S(=O)(=O)C(C)C)nc(Cl)nc32)cc1.Cc1cc(N)c(OC(C)C)cc1C1CCNCC1>>Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3nn[nH]c3n2)c(OC(C)C)cc1C1CCNCC1,,C1COCCO1,Cl,,,val
US05877317,CCOC(CCCl)OCC.OCCc1ccccc1>>CCOC(CCCl)OCCc1ccccc1,,C[N+](=O)[O-],,CS(=O)(=O)O,,val
US20120077828A1,Nc1nccc2occ(-c3ccc4c(c3F)CCN4C(=O)Cc3cc(F)ccc3F)c12.O=C1CCC(=O)N1I>>Nc1ncc(I)c2occ(-c3ccc4c(c3F)CCN4C(=O)Cc3cc(F)ccc3F)c12,,CN(C)C=O,,O,,val
US20130102645A1,CNC(=S)Nc1ccc(C(=O)O)cc1.COC(=O)CBr>>CN1C(=O)CSC1=Nc1ccc(C(=O)O)cc1,,C1COCCO1,,,,val
US20090253687A1,NC(=O)c1cc(-c2ccc3c(c2)NC(=O)CO3)n(-c2ccc(F)cc2)n1>>N#Cc1cc(-c2ccc3c(c2)NC(=O)CO3)n(-c2ccc(F)cc2)n1,,CN(C)C=O,,O=C(Cl)C(=O)Cl,,val
US20020111367A1,CCOC(=O)c1cnc(N2CCOCC2)cc1Oc1ccccc1>>O=C(O)c1cnc(N2CCOCC2)cc1Oc1ccccc1,,O,,CO,[Na+].[OH-],val
US03989507,CC(C)NS(=O)(=O)Cl.COC(=O)c1cccnc1N>>COC(=O)c1cccnc1NS(=O)(=O)NC(C)C,,c1ccccc1,,,,val
US20100298339A1,C[C@H](CO)NC(=O)OC(C)(C)C.Oc1ccc(Br)cc1>>C[C@H](COc1ccc(Br)cc1)NC(=O)OC(C)(C)C,,Cc1ccccc1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080045532A1,O=C(O)Cc1ccc(-n2nc(C(F)(F)F)c3c2CCCC3)cc1.c1ccc(C2CCCN2)cc1>>O=C(Cc1ccc(-n2nc(C(F)(F)F)c3c2CCCC3)cc1)N1CCCC1c1ccccc1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20090209755A1,C=CCC(O)CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.CCI>>C=CCC(CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)OCC,,C1CCOC1,,[H-].[Na+],,val
US20100216860A1,CN(C)CCOc1ccc(CO)cc1.COc1cccc2[nH]nc(N(S(=O)(=O)c3ccc(Cl)s3)S(=O)(=O)c3ccc(Cl)s3)c12>>COc1cccc2c1c(N(S(=O)(=O)c1ccc(Cl)s1)S(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(OCCN(C)C)cc1,,C1CCOC1,ClCCl,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060025433A1,CC(C)(C)OC(=O)NC1CCC(CNc2nc(NCc3ccccc3OC(F)(F)F)ncc2Br)CC1>>N[C@@H]1CC[C@@H](CNc2nc(NCc3ccccc3OC(F)(F)F)ncc2Br)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05808062,C=O.O=c1cc(O)cc(-c2ccccc2)o1.Sc1ccccc1>>O=c1oc(-c2ccccc2)cc(O)c1CSc1ccccc1,,CC(=O)O,CCO,C1CCNCC1,,val
US20090082358A1,O=C(c1ccc(C(F)(F)F)cc1)c1ccncc1CCN1C(=O)c2ccccc2C1=O>>FC(F)(F)c1ccc(C2=NCCc3cnccc32)cc1,,CCO,,NN,O,val
US20030100770A1,CC(C)(C)OC(=O)[C@H]1CCCN1C(=O)CCN(CCC(=O)N1CCC[C@@H]1C(=O)OC(C)(C)C)Cc1ccc(C(F)(F)F)cc1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C(O)[C@H]1CCCN1C(=O)CCN(CCC(=O)N1CCC[C@@H]1C(=O)O)Cc1ccc(C(F)(F)F)cc1,,CCOCC,ClCCl,,,val
US04409220,Nc1cnc2c(n1)CCN(C(=O)c1ccc(Cl)cc1)CC2>>Nc1cnc2c(n1)CCN(Cc1ccc(Cl)cc1)CC2,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20080167361A1,Cc1cc(S(=O)(=O)c2cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc23)ccc1C1CCN(C)C1>>Cc1cc(S(=O)(=O)c2c[nH]c3ccc(F)cc23)ccc1C1CCN(C)C1,,CO,,[Na+].[OH-],,val
US20110306588A1,CC(C)(C)[Si](C)(C)OC1CC=C(c2nccnc2OC2CN(C(=O)c3nc4ccccc4[nH]3)C2)CC1>>O=C(c1nc2ccccc2[nH]1)N1CC(Oc2nccnc2C2=CCC(O)CC2)C1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140162971A1,CS(=O)(=O)c1ccc(F)c([N+](=O)[O-])c1.Oc1ccc(F)cc1F>>CS(=O)(=O)c1ccc(Oc2ccc(F)cc2F)c([N+](=O)[O-])c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20070093453A1,COc1cc(OC)c(C=O)cc1C#Cc1ccccc1N>>COc1cc(OC)c(CO)cc1C#Cc1ccccc1N,,C1CCOC1,CO,[BH4-].[Na+],,val
US20060235031A1,O=C(O)c1ccc2ccc(-c3ccccc3)nc2c1>>OCc1ccc2ccc(-c3ccccc3)nc2c1,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20040038943A1,COc1ccc(-c2cc3cc(F)c(F)cc3[nH]2)cc1N.O=Cc1ccc([N+](=O)[O-])c(O)c1>>COc1ccc(-c2cc3cc(F)c(F)cc3[nH]2)cc1NCc1ccc([N+](=O)[O-])c(O)c1,,CC(=O)O,ClCCl,O=C([O-])O.[Na+],,val
US20160108050A1,C1COCCN1.N#Cc1cc(N)c(Cl)cc1CCC=O>>N#Cc1cc(N)c(Cl)cc1CCCN1CCOCC1,,C1CCOC1,,CC(=O)O,[BH3-]C#N.[Na+],val
US20020137689A1,CN(CC(O)C(O)C(O)C(O)CO)C(=O)CCCC=Cc1ccc(C2C(CCC(O[Si](C)(C)C(C)(C)C)c3ccc(F)cc3)C(=O)N2c2ccc(F)cc2)cc1>>CN(CC(O)C(O)C(O)C(O)CO)C(=O)CCCC=Cc1ccc(C2C(CCC(O)c3ccc(F)cc3)C(=O)N2c2ccc(F)cc2)cc1,,CO,,Cl,[Na+].[OH-],val
US20100056573A1,NC1CCNCC1.O=Cc1ccccc1>>C(=NC1CCNCC1)c1ccccc1,,Cc1ccccc1,,,,val
US20030008901A1,COC(=O)C1CCC(C)(O)CN1S(=O)(=O)c1ccc(OCc2ccccc2)cc1>>CC12CCC(C(=O)O1)N(S(=O)(=O)c1ccc(OCc3ccccc3)cc1)C2,,CCOC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US20160046597A1,Cn1cc(C2CCN(C(=O)OC(C)(C)C)CC2)c2cc(NS(=O)(=O)c3ccc(F)cc3)ccc21>>Cn1cc(C2CCNCC2)c2cc(NS(=O)(=O)c3ccc(F)cc3)ccc21,,C1COCCO1,CO,Cl,O=C([O-])O.[Na+],val
US20120010228A1,CC(C)(C)OC(=O)c1ccccc1CN1CN(C2CCCCC2)C2(CCNCC2)C1=O.O=C(CCCI)c1ccccc1>>CC(C)(C)OC(=O)c1ccccc1CN1CN(C2CCCCC2)C2(CCN(CCCC(=O)c3ccccc3)CC2)C1=O,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US07230007B2,O=C(Cl)C(=O)Cl.O=C(O)c1cn(-c2nccc3ccccc23)c2ncccc12>>Cl.O=C(Cl)c1cn(-c2nccc3ccccc23)c2ncccc12,,ClCCl,,,,val
US20040116708A1,O=C(O)c1ccnc(Cl)c1.OCc1ccccc1>>O=C(O)c1ccnc(OCc2ccccc2)c1,,CN(C)C=O,O,Cl,[H-].[Na+],val
US20150361067A1,NCCc1cc(Cl)ccc1Br.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>O=C(NCCc1cc(Cl)ccc1Br)Oc1ccc([N+](=O)[O-])cc1,,ClCCCl,O,O=C([O-])[O-].[Na+].[Na+],,val
US20030139464A1,COC(=O)C(CN1C(=O)c2cccc(O)c2C1=O)C1(C)OCCO1>>COC(=O)C(CN1C(=O)c2cccc(O)c2C1=O)C(C)=O,,CC(C)=O,O,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110190263A1,CC(C)c1noc(N2CCC(CCCOS(C)(=O)=O)CC2)n1.CS(=O)(=O)N1CCc2nc(O)ncc2C1>>CC(C)c1noc(N2CCC(CCCOc3ncc4c(n3)CCN(S(C)(=O)=O)C4)CC2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140343035A1,CC(C)(C)OC(=O)N1CCC(CO)C1.COc1cc(C#Cc2n[nH]c3ncnc(N)c23)cc(OC)c1>>COc1cc(C#Cc2nn(CC3CCN(C(=O)OC(C)(C)C)C3)c3ncnc(N)c23)cc(OC)c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140221343A1,C1CCOC1.O=Cc1cc2c(cc1I)OCO2>>C=Cc1cc2c(cc1I)OCO2,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20090093483A1,CC(C)(C)OC(=O)CN.CCOC(=O)C1=C(O)c2cc(Cl)cc(F)c2C(C)(C)C1=O>>CC(C)(C)OC(=O)CNC(=O)C1=C(O)c2cc(Cl)cc(F)c2C(C)(C)C1=O,,C1COCCO1,CCOC(C)=O,CCN(C(C)C)C(C)C,Cl,val
US05218110,CC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=C(N=[N+]=[N-])C(=O)CC[C@]4(C)[C@H]3CC[C@]12C>>CC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=C(N)C(=O)CC[C@]4(C)[C@H]3CC[C@]12C,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070105889A1,C[C@@H](Cn1ccc2ccc3ccccc3c21)NC(=O)OC(C)(C)C>>C[C@@H](CN1CCc2ccc3ccccc3c21)NC(=O)OC(C)(C)C,,CC(=O)O,,[BH3-]C#N.[Na+],,val
US20060148797A1,C1=C(c2ccccc2)CCNC1.O=C(Cl)c1cc([N+](=O)[O-])ccc1N1CCOCC1>>O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CC=C(c2ccccc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20050014767A1,c1nc2cc(-c3ccc(C4OCCO4)cn3)cc(C34CC5CC(CC(C5)C3)C4)c2o1>>O=Cc1ccc(-c2cc(C34CC5CC(CC(C5)C3)C4)c3ocnc3c2)nc1,,CC(C)=O,O,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20040044057A1,COC(=O)CSCc1c(O)ccc2c1CCCC2=O.O[C@@H](Cn1ccnc1)c1ccccc1>>COC(=O)CSCc1c(O[C@H](Cn2ccnc2)c2ccccc2)ccc2c1CCCC2=O,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120208815A1,CC(C)(C)OC(=O)N[C@H]1CN(C(=O)OCc2ccccc2)CC[C@@H]1O.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N[C@H]1CN(C(=O)OCc2ccccc2)CC[C@@H]1OS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US05646173,CC(O)CN.COc1ccc2c(c1)C(=O)C(CC=O)C2>>COc1ccc2c(c1)-c1c(ccn1CC(C)O)C2,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,O,,val
US07074817B2,Brc1ccc2ccn(Cc3ccccc3)c2c1.OB(O)c1ccccc1>>c1ccc(Cn2ccc3ccc(-c4ccccc4)cc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20050059729A1,Cc1c(-c2ccccc2)sc2ccc(Cl)cc12.O=C1CCC(=O)N1Br>>Clc1ccc2sc(-c3ccccc3)c(CBr)c2c1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20050227972A1,CC(=O)C(Cl)Cl.NC(=S)N1CCOCC1>>ClCc1csc(N2CCOCC2)n1,,CCO,,,,val
US06420418B1,CC(C)C=O.COC(=O)C1CCCO1>>COC(=O)C1(C(O)C(C)C)CCCO1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20130211075A1,Cc1cc(Br)cnc1C1=CCNCC1.O=C1CCOCC1>>Cc1cc(Br)cnc1C1=CCN(C2CCOCC2)CC1,,C1CCOC1,CCCCCC,[Na+].[OH-],,val
US20090054413A1,CSc1nn(-c2ccccc2)c(N)c1C(=O)NCC(=O)c1ccccc1>>CSc1nn(-c2ccccc2)c2c1C(=O)NCC(c1ccccc1)=N2,,Cc1ccccc1C,,,,val
US20090149425A1,CC(C)(O)c1cc(C=O)no1.N#CCC#N>>CC(C)(O)c1cc(C=C(C#N)C#N)no1,,CCO,,,,val
US20050059705A1,COC(=O)[C@@H](NC(=O)c1cc2ccc(C(=O)NC3CCC(C(C)(C)C)CC3)cc2c(CC2CCCC2)n1)C(C)(C)C>>CC(C)(C)C1CCC(NC(=O)c2ccc3cc(C(=O)N[C@H](C(=O)O)C(C)(C)C)nc(CC4CCCC4)c3c2)CC1,,C1CCOC1,CO,[Li+].[OH-],,val
US20120214769A1,CC(C)(C)c1ccc(CC(=O)OCc2ccccc2)cc1.COC(=O)c1ccc(C(C)Br)cc1>>COC(=O)c1ccc(C(C)C(C(=O)OCc2ccccc2)c2ccc(C(C)(C)C)cc2)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20040082570A1,C=Cc1ccccc1-n1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2c1c(=O)n(COC(=O)C(C)(C)C)c(=O)n2C>>C=Cc1ccccc1-n1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2c1c(=O)[nH]c(=O)n2C,,CO,,Cl,[H-].[Na+],val
US20070066595A1,COc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(O)ccc2c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(OS(=O)(=O)C(F)(F)F)ccc2c1,,ClCCl,,CCN(CC)CC,,val
US20100234377A1,COC(=O)c1ccccc1C(=O)N1CCN(C(=O)Nc2ccc(F)cc2)CC1>>O=C(Nc1ccc(F)cc1)N1CCN(C(=O)c2ccccc2CO)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140275092A1,CCCBr.CCOC(=O)CC(C)=O>>CCCC(C(C)=O)C(=O)OCC,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20060211709A1,OC1CCc2cc(-c3cccs3)ccc21.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=NC1CCc2cc(-c3cccs3)ccc21,,C1CCOC1,CCOC(C)=O,C1CCC2=NCCCN2CC1,,val
US20120302756A1,CCC/C(=N\[S@@](=O)C(C)(C)C)c1ccccc1>>CCC[C@@H](NS(=O)C(C)(C)C)c1ccccc1,,CO,,,,val
US20130079328A1,CC(C)(C)OC(=O)c1ccc(Br)cn1.OB(O)c1cccc(F)c1>>CC(C)(C)OC(=O)c1ccc(-c2cccc(F)c2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20120142717A1,O=Cc1cc(F)c(F)c(F)c1.Oc1ccc(Cl)c(C(F)(F)F)c1>>O=Cc1cc(F)c(Oc2ccc(Cl)c(C(F)(F)F)c2)c(F)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040248951A1,COC(=O)COc1ccc(N(Cc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)C(=O)OC(C)(C)C)cc1C>>COC(=O)COc1ccc(NCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060063762A1,CCC(=O)Cl.C[C@H](Cc1c[nH]c2c(N)cccc12)N1C[C@@H](c2cccc(Cl)c2)OC1=O>>CCC(=O)Nc1cccc2c(C[C@@H](C)N3C[C@@H](c4cccc(Cl)c4)OC3=O)c[nH]c12,,C1CCOC1,,CCN(CC)CC,O,val
US20160108035A1,CCOC(=O)C1(Sc2ccnc3ccc(OCC(=O)NC)cc23)CCC1>>CNC(=O)COc1ccc2nccc(SC3(C(=O)O)CCC3)c2c1,,C1CCOC1,O,[Na+].[OH-],,val
US20080090875A1,CCOC(=O)Cc1ccc(OCC)cc1.CS(=O)(=O)c1ccc(C(=O)O)cc1>>CCOC(=O)C(C(=O)c1ccc(S(C)(=O)=O)cc1)c1ccc(OCC)cc1,,CN(C)C=O,O,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20040039038A1,CN(Cc1cccc(-c2ccc(C=C3SC(=O)NC3=O)cc2)c1)C(=O)CCc1ccccc1>>CN(Cc1cccc(-c2ccc(CC3SC(=O)NC3=O)cc2)c1)C(=O)CCc1ccccc1,,C1CCOC1,,,,val
US20020132810A1,CC(C)CCC(CC(O)C(N)Cc1ccccc1)S(=O)(=O)c1ccccc1.O=C(O)c1cnc2ccccc2n1>>CC(C)CCC(CC(O)C(Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)S(=O)(=O)c1ccccc1,,ClCCl,,CN1CCOCC1,,val
US20070219266A1,O=C(Cl)c1ccc(F)cc1.O=C(c1ccc(F)cc1)C1CCNC1>>O=C(c1ccc(F)cc1)C1CCN(C(=O)c2ccc(F)cc2)C1,,ClCCl,,CCN(CC)CC,Cl,val
US20090111796A1,COCOc1ccc(C)cc1/C=C1\CNC(=O)CN(S(=O)(=O)c2ccc(Cl)cc2)C1=O>>Cc1ccc(O)c(/C=C2\CNC(=O)CN(S(=O)(=O)c3ccc(Cl)cc3)C2=O)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060094762A1,COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C.[Mg]>>COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C.[Mg],,CO,,II,,val
US06936602B1,CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CCN3C=O)cc1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CCN3)cc1,,C1CCOC1,Cl,,,val
US20100035936A1,CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCc2c(cccc2OS(=O)(=O)C(F)(F)F)C1.Cc1nn(C)c(C)c1B1OC(C)(C)C(C)(C)O1>>Cc1nn(C)c(C)c1-c1cccc2c1CC[C@H](N(Cc1ccccc1)C(=O)C(C)(C)C)C2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20150057271A1,COc1cc(C#N)ccc1N1CCOc2ccccc21.O=S(=O)(O)Cl>>COc1cc(C#N)ccc1N1CCOc2cc(S(=O)(=O)Cl)ccc21,,ClCCl,,,,val
US20160205936A1,CC(C)(C)OC(=O)N1CC2(C1)OCc1cc(C(=O)C=C(c3cc(Cl)c(F)c(Cl)c3)C(F)(F)F)ccc12.CC(O)=S>>CC(=S)C(CC(=O)c1ccc2c(c1)COC21CN(C(=O)OC(C)(C)C)C1)(c1cc(Cl)c(F)c(Cl)c1)C(F)(F)F,CCN(CC)CC,ClCCl,,,,val
US20090062253A1,CC(C)(C)c1ccc(C(=O)c2cccnc2CCCN2C(=O)c3ccccc3C2=O)cc1>>CC(C)(C)c1ccc(C2=NCCCc3ncccc32)cc1,,O,,Cl,[Na+].[OH-],val
US20080096897A1,Nc1ccc(N2CCNCC2)cc1.O=C1NC(=O)C(Br)(c2ccc(-c3ccccc3)cc2)C(=O)N1>>Nc1ccc(N2CCN(C3(c4ccc(-c5ccccc5)cc4)C(=O)NC(=O)NC3=O)CC2)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20040209887A1,COc1ccc(-c2c(C)ccn2N2C(=O)c3ccccc3C2=O)c(C)c1>>COc1ccc(-c2c(C)ccn2N)c(C)c1,,CCO,,NN,O,val
US20110274591A1,C1CCCCC1.O=C(O)CCCCC(=O)O>>O=C1CCCCC1.OC1CCCCC1,,C1CCCCC1,,,,val
US20040106631A1,COc1c(Br)cc(F)cc1Br.O=[N+]([O-])O>>COc1c(Br)cc(F)c([N+](=O)[O-])c1Br,,O=S(=O)(O)O,,,,val
US20090270435A1,CC(=O)c1ccccc1O.CC(C)(C)OC(=O)N1CCC(=O)CC1>>CC(C)(C)OC(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2,,CO,,C1CCNC1,,val
US20050222183A1,COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1>>COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150232445A1,C=CCn1c(Br)nc2ccccc21.CC(=O)N1c2ccc(Br)c(O)c2CC[C@@H]1C>>C=CCn1c(Oc2c(Br)ccc3c2CC[C@H](C)N3)nc2ccccc21,,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20150111885A1,O=C1CCC(=O)N1Br.O=c1[nH]ccc2ncncc12>>O=c1[nH]cc(Br)c2ncncc12,,CN(C)C=O,,,,val
US20060025601A1,COCN(Cc1ccccc1)C[Si](C)(C)C.COc1ccc2c(c1)C=CC2=O>>COc1ccc2c(c1)C1CN(Cc3ccccc3)CC1C2=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060148858A1,COC(=O)CCc1cccc(O)c1.OCc1cn(-c2ccc(C(F)(F)F)cn2)nc1C1CCCCC1>>O=C(O)CCc1cccc(OCc2cn(-c3ccc(C(F)(F)F)cn3)nc2C2CCCCC2)c1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US05256675,Cc1nc(N)sc1Br.Sc1ccccn1>>Cc1nc(N)sc1Sc1ccccn1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20160177010A1,C=CC(=C)Cl.O=S(=O)(CCCI)c1ccccc1>>C=CC(=C)CCCS(=O)(=O)c1ccccc1,,C1CCOC1,,,,val
US20140155391A1,COc1ccc(C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)cc1NC(=O)CC(=O)N1C[C@@H](C)N(C(=O)OC(C)(C)C)C[C@@H]1C>>COc1ccc(C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)cc1NC(=O)CC(=O)N1C[C@@H](C)NC[C@@H]1C,,C1COCCO1,Cl,,,val
US20080275252A1,CCC1(c2c[nH]cn2)Cc2ccccc2C1O.Cl>>CCC1(c2c[nH]cn2)Cc2ccccc2C1.Cl,[Pd],CCO,,O,[H][H],val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3[nH]c(C(F)(F)C(F)(F)F)nc3c2)cc1.Cl>>Cc1cc(C(=O)NC2CCNCC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc3[nH]c(C(F)(F)C(F)(F)F)nc3c2)cc1.Cl,,C1COCCO1,,,,val
US06008245,CC(=O)OC(C)=O.CN(C1c2cc(OCc3ccccc3)ccc2OC(C)(C)C1O)S(C)(=O)=O>>CC(=O)OC1C(N(C)S(C)(=O)=O)c2cc(OCc3ccccc3)ccc2OC1(C)C,,c1ccncc1,,,,val
US20080293776A1,O=[N+]([O-])c1ccc(F)cc1OCc1ccccc1.Sc1ccccc1>>O=[N+]([O-])c1ccc(Sc2ccccc2)cc1OCc1ccccc1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US04081542,CO.Clc1cncc(Cl)n1>>COc1cncc(Cl)n1,,CO,,C[O-].[Na+],,val
US20060030583A1,Brc1cnc2[nH]ccc2c1.O=C(c1cccc(B(O)O)c1)N1CCOCC1>>O=C(c1cccc(-c2cnc3[nH]ccc3c2)c1)N1CCOCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])O.[Na+],,val
US20140275173A1,Cc1ccc(S(=O)(=O)OCC2(COS(=O)(=O)c3ccc(C)cc3)CCC(=O)CC2)cc1.Fc1cc([Mg]Br)cc(OC2CCCCO2)c1F>>Cc1ccc(S(=O)(=O)OCC23CCC(c4cc(F)c(F)c(OC5CCCCO5)c4)(CC2)OC3)cc1,,C1CCOC1,,[Na+].[OH-],,val
US20130023534A1,Cc1c(N(C)c2ccnc(Cl)n2)nn(C(=O)OC(C)(C)C)c1C>>Cc1[nH]nc(N(C)c2ccnc(Cl)n2)c1C,,ClCCl,,Cl,,val
US20150141641A1,COC(=O)c1cc(F)ccc1NS(=O)(=O)c1ccc(C)cc1.N#CCCCCl>>COC(=O)c1cc(F)ccc1N(CCCC#N)S(=O)(=O)c1ccc(C)cc1,,CCC(C)=O,,[I-].[K+],,val
US20160159752A1,CC(C)(C)[Si](C)(C)OCCC[C@H]1CN(Cc2ccccc2)CCN1.O=S(=O)(Cl)c1ccccc1>>CC(C)(C)[Si](C)(C)OCCC[C@H]1CN(Cc2ccccc2)CCN1S(=O)(=O)c1ccccc1,,ClCCl,,,,val
US05886044,O=[N+]([O-])c1cccc(-c2ccccc2)c1O>>Nc1cccc(-c2ccccc2)c1O,[Pd],CO,,,,val
US20090227640A1,BrCc1ccc(Br)cc1.COC(=O)c1ccc(CN(CCc2ccccc2O)C(=O)OC(C)(C)C)cc1>>COC(=O)c1ccc(CN(CCc2ccccc2OCc2ccc(Br)cc2)C(=O)OC(C)(C)C)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060128790A1,CC1=C2OC3(CCC3)CCC2=CC(O)C1(C)Cl.CN(C)CC(=O)Cl>>Cc1c2c(c(C)c(Cl)c1OC(=O)CN(C)C)OC1(CCC1)CC2,,CCOC(C)=O,,Cl,ClCCl,val
US20050101541A1,CCCCCCCCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCCCCCCCC.COc1cc(C[C@H]2COC(=O)[C@@H]2Cc2ccc(O)c(OC)c2)ccc1O>>CCCCCCCCCCCCCCCCCC(=O)[O-].COc1cc(C[C@H]2COC(=O)[C@@H]2Cc2ccc(O)c(OC)c2)ccc1O,,c1ccncc1,,,,val
US05985909,CCCCOC(=O)CNC(=O)c1ccc2cc(C(=O)N3CC(CCl)c4ccc([N+](=O)[O-])cc43)[nH]c2c1>>O=C(O)CNC(=O)c1ccc2cc(C(=O)N3CC(CCl)c4ccc([N+](=O)[O-])cc43)[nH]c2c1,,Cl,,C1COCCO1,,val
US20040157885A1,CCOC(=O)C(C)(C)Oc1cc(C2CCCN(C(=O)c3sc(-c4ccc(C(F)(F)F)cc4)nc3C)C2)ccc1C>>Cc1ccc(C2CCCN(C(=O)c3sc(-c4ccc(C(F)(F)F)cc4)nc3C)C2)cc1OC(C)(C)C(=O)O,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US04978753,CCOC(=O)C#CC(=O)OCC.NC1=Nc2ccc([N+](=O)[O-])cc2C(c2ccccc2Cl)=NC1>>CCOC(=O)c1cc(=O)nc2n1-c1ccc([N+](=O)[O-])cc1C(c1ccccc1Cl)=NC2,,CCO,,,,val
US20110144339A1,CC(C)(C)OC(=O)OC(=O)[O-].CC1(N)CN(Cc2ccccc2)CC12CC2>>CC(C)(C)OC(=O)NC1(C)CN(Cc2ccccc2)CC12CC2,,Cc1ccccc1,,[Na+].[OH-],,val
US20130252934A1,CC(C)(C)[Si](C)(C)OC[C@H](c1ccc(Cl)c(F)c1)n1ccc(-c2ccnc(S(C)(=O)=O)n2)cc1=O.Cc1nn(C)cc1N>>Cc1nn(C)cc1Nc1nccc(-c2ccn([C@H](CO[Si](C)(C)C(C)(C)C)c3ccc(Cl)c(F)c3)c(=O)c2)n1,,CCC(C)O,,O,,val
US20120101100A1,CCCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2cc(C(=O)OC3CCOCC3)cnc2OC2CCOCC2)cn1>>CCCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2cc(C(=O)O)cnc2OC2CCOCC2)cn1,,C1CCOC1,O,[Li+].[OH-],,val
US20120101080A1,CCC(C=O)CC(=O)OC.NCCc1ccccn1>>CCC1=CC(=O)N(CCc2ccccn2)C1,,CC(=O)O,,,,val
US04279637,COC(CN(C)C(=O)Nc1ccc(Oc2ccc(C)cc2)c(Cl)c1)OC>>Cc1ccc(Oc2ccc(-n3ccn(C)c3=O)cc2)cc1Cl,,O,,Cl,,val
US20070105943A1,CC(C)(C)c1ccc(CN)cc1.Clc1ncnc2ccccc12>>CC(C)(C)c1ccc(CNc2ncnc3ccccc23)cc1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US05077402,CCC(Cc1ccccc1)(C(=O)c1ccc(F)cc1)N(C)C.CNC>>CCC(Cc1ccccc1)(C(=O)c1ccc(N(C)C)cc1)N(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100234365A1,CS(=O)(=O)Cl.O=C1[C@@H](CCCO)C[C@H](c2cccc(C(F)(F)F)c2)N1c1ccc(Oc2ccc(Cl)cc2)cc1>>CS(=O)(=O)OCCC[C@H]1C[C@H](c2cccc(C(F)(F)F)c2)N(c2ccc(Oc3ccc(Cl)cc3)cc2)C1=O,,ClCCl,,,,val
US20050245543A1,C[C@H](c1ccc(-c2ccc(-c3ccncc3)cc2)cc1)N1CCCC1>>C[C@H](c1ccc(-c2ccc(C3CCNCC3)cc2)cc1)N1CCCC1,O=[Pt],CO,,[H][H],,val
US20150284395A1,CCOC(=O)c1ccc(Cl)c(OCC)c1>>CCOc1cc(C(=O)O)ccc1Cl,,CO,O,Cl,[Na+].[OH-],val
US20150166480A1,CCC(F)(CC)CN1CCC(COc2ccc(-c3ccc(C(=O)OC)cc3F)cc2C#N)CC1>>CCC(F)(CC)CN1CCC(COc2ccc(-c3ccc(C(=O)O)cc3F)cc2C#N)CC1,,O,,[Li]O,,val
US20040122063A1,CCOC(=O)[C@@H]1CC[C@@H]2O[C@@H]2C1.[N-]=[N+]=[N-]>>CCOC(=O)[C@@H]1CC[C@H](O)[C@@H](N=[N+]=[N-])C1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20060199962A1,COC(=O)c1c(C)c(C(=O)c2ccc([N+](=O)[O-])c(OC)c2)n2cccc(O)c12.COS(=O)(=O)OC>>COC(=O)c1c(C)c(C(=O)c2ccc([N+](=O)[O-])c(OC)c2)n2cccc(OC)c12,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160102071A1,CC#C[C@@H](CC(=O)OC)c1ccc(OCc2ccc3scc(-c4ccc(O)cc4C)c3c2)cc1>>CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3scc(-c4ccc(O)cc4C)c3c2)cc1,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20130203727A1,C=Cc1c(C)c(C(OC(C)(C)C)C(=O)O)c(-c2ccc(Cl)cc2)c2ccccc12>>CCc1c(C)c(C(OC(C)(C)C)C(=O)O)c(-c2ccc(Cl)cc2)c2ccccc12,[Rh],CCO,,,,val
US04990511,O=C(O)Cc1ccc(OCc2ccccc2)cc1OCc1ccccc1.c1ccc(CC2CCNCC2)cc1>>O=C(Cc1ccc(OCc2ccccc2)cc1OCc1ccccc1)N1CCC(Cc2ccccc2)CC1,,CN(C)C=O,O,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US04835164,CCOc1ccccc1OCC1OCC(=O)N2CCCCC12>>CCOc1ccccc1OCC1OCCN2CCCCC12,,C1CCOC1,ClC(Cl)Cl,B,,val
US04760052,CC(C)(C)OC(=O)C(N)(CCCC1(CC(=O)OCc2ccccc2)CCCCC1)C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)C(N)(CCCC1(CC(=O)OCc2ccccc2)CCCCC1)C(=O)O,,C1COCCO1,,Cl,[Na+].[OH-],val
US04792628,C=CCBr.Cc1ccc(O)c2c1CCC2=O>>C=CCOc1ccc(C)c2c1C(=O)CC2,,CO,,[K+].[OH-],,val
US05831099,C1CCOC1.C=C1CC(NS(=O)(=O)c2ccc(C)cc2)CC(=C)NN(NS(=O)(=O)c2ccc(C)cc2)C1>>CC1CNCC(C)(C2CCCCCCC2)CNC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04515948,COC(=O)c1cc(OC)c(N(C)C(=O)OCc2ccccc2)c(OC)c1>>CNc1c(OC)cc(C(=O)OC)cc1OC,[Pd],CO,,[H][H],,val
US20160166560A1,CN(C(=O)n1cnc(-c2cccc(NC(N)=O)c2)c1)C1CCN(c2ccc(O)cc2)CC1.Cl>>CN(C(=O)n1cnc(-c2cccc(NC(N)=O)c2)c1)C1CCN(c2ccc(O)cc2)CC1.Cl,,CCOC(C)=O,CO,CCOCC,,val
US04550169,CCBr.OC1CNC(=S)NC1>>Br.CCSC1=NCC(O)CN1,,CCOCC,,CCO,,val
US05707982,CCCCN(C)C(=O)CBr.OCCCCCS>>CCCCN(C)C(=O)CSCCCCCO,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US05552426,COc1cc(C(=O)Cl)cc(OC)c1OC.Nc1ccccc1Nc1ccccc1>>COc1cc(C(=O)Nc2ccccc2Nc2ccccc2)cc(OC)c1OC,,CCOCC,,,,val
US04020169,CCOC(=O)c1ccccc1SC(F)(F)F>>O=C(O)c1ccccc1SC(F)(F)F,,CCO,,Cl,[Na+].[OH-],val
US20100286152A1,CCOC(=O)C(c1ccc(C)nc1C)N1CCN2CCC[C@@H]2C1.[K+]>>Cc1ccc(C(C(=O)[O-])N2CCN3CCC[C@@H]3C2)c(C)n1.[K+],,CO,,O,,val
US20110245264A1,COc1cc(OS(=O)(=O)C(F)(F)F)ccc1[C@H](CO)NC(=O)[C@H]1C[C@@H]1c1cccs1.Cc1ccccc1B(O)O>>COc1cc(-c2ccc(C)cc2)ccc1[C@H](CO)NC(=O)[C@H]1C[C@@H]1c1cccs1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US05536737,CC(C)(C)OC(=O)N1CCC[C@H]1C1CO1.COc1ccc(O)cc1>>COc1ccc(OCC(O)[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1,,CO,,O,C[O-].[Na+],val
US20080188528A1,Br[Mg]c1ccccc1.O=C(c1ccccc1)c1cccc(Br)c1>>OC(c1ccccc1)(c1ccccc1)c1cccc(Br)c1,,c1ccccc1,,Cl,,val
US20050107389A1,Cc1csc(C(=O)C2CCN(C(=O)OC(C)(C)C)CC2)c1Br.[NH4+].[OH-]>>Cc1csc(C(=NO)C2CCN(C(=O)OC(C)(C)C)CC2)c1Br,,c1ccncc1,,Cl,Cl,val
US20150291636A1,COP(=O)(CP(=O)(OC)OC)OC.O=C[C@@H](OCc1ccccc1)[C@H](OCc1ccccc1)[C@@H](CN(C=O)OCc1ccccc1)OCc1ccccc1>>COP(=O)(/C=C/[C@@H](OCc1ccccc1)[C@H](OCc1ccccc1)[C@@H](CN(C=O)OCc1ccccc1)OCc1ccccc1)OC,,CCOCC,,[H-].[Na+],,val
US20020124980A1,CC1(C)CC(OCC2CO2)CC(C)(C)N1O.OCCNCCO>>CC1(C)CC(OCC(O)CN(CCO)CCO)CC(C)(C)N1O,,O,,,,val
US20050209241A1,COC(=O)c1cnc(N2CCN(C(=O)OC(C)(C)C)CC2)cn1.Cl>>COC(=O)c1cnc(N2CCNCC2)cn1.Cl,,C1COCCO1,,,,val
US20080051578A1,N#Cc1c[nH]nc1N.O=[N+]([O-])c1ccc(F)cc1>>N#Cc1cn(-c2ccc([N+](=O)[O-])cc2)nc1N,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100063041A1,CC(NC(=O)c1ccc(Br)cc1)C(=O)[O-]>>CC(NC(=O)c1ccc(Br)cc1)C(=O)O,,CO,,[Na+].[OH-],,val
US20050107364A1,CC(=O)OC(C)=O.COC1=CCc2ccccc2[C@]1(CCC(C)C)C(=O)N1CCC[C@@H]1CO>>COC1=CCc2ccccc2[C@]1(CCC(C)C)C(=O)N1CCC[C@@H]1COC(C)=O,,ClCCl,c1ccncc1,,,val
US06436962B1,C=CC#N.N#CC1(c2ccccc2)CCNCC1>>N#CCCN1CCC(C#N)(c2ccccc2)CC1,,CO,,,,val
US20040102450A1,C[Mg+].O=C1CCc2cc(Cl)ccc2C1.[Br-]>>Clc1ccc2cc(CBr)ccc2c1,Cl[Ti](Cl)(Cl)Cl,O,,ClCCl,,val
US20100056516A1,CC(=O)c1cnc2c(c1)c(O)c(-c1ccccc1)c(=O)n2OCc1ccccc1.NCc1cccc(Cl)c1>>CC(NCc1cccc(Cl)c1)c1cnc2c(c1)c(O)c(-c1ccccc1)c(=O)n2OCc1ccccc1,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05856334,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.OC1CCn2c(CCc3ccccc3)nc3cccc1c32>>SC1CCn2c(CCc3ccccc3)nc3cccc1c32,,Cc1ccccc1C,,,,val
US05159083,COc1cccc(-c2ncc3n2CC(=O)N(C)C3)c1>>COc1cccc(-c2ncc3n2C=CN(C)C3)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090203647A1,COC(OC)N(C)C.Nc1nc(O)ncc1F>>CN(C)C=Nc1nc(O)ncc1F,,CCOCC,CN(C)C=O,,,val
US04022769,C[C@@H]1CC2=CC(=O)C[C@H](C)[C@]2(CO)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3O)[C@@H]21>>C[C@@H]1CC2=CC(=O)C[C@H](C)[C@]2(C=O)[C@H]2CC[C@]3(C)C(=O)CC[C@H]3[C@@H]21,,CC(C)=O,,O=S(=O)(O)O,O=[Cr](=O)=O,val
US20090253747A1,Nc1ccccc1NC1CCN([C@@H]2Cc3cccc4cccc2c34)CC1.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]c2ccccc2n1C1CCN([C@@H]2Cc3cccc4cccc2c34)CC1,,C1CCOC1,,O,,val
US04717720,CCCCCCCCCCI.Oc1ccc(Br)cc1C12CC3CC(CC(C3)C1)C2>>CCCCCCCCCCOc1ccc(Br)cc1C12CC3CC(CC(C3)C1)C2,,C1CCOC1,O,CN(C)C=O,[H-].[Na+],val
US05559113,ClCc1c[nH]cn1.NC(N)=S.O=[N+]([O-])c1ccc(CCl)cc1>>O=[N+]([O-])c1ccc(CSCc2c[nH]cn2)cc1,,CCO,O,Cl,[Na+].[OH-],val
US09428503B2,CN(C)CCCO.Oc1ccc(Br)c(F)n1>>CN(C)CCCOc1ccc(Br)c(F)n1,,ClCCl,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04535089,CCCCCC(=O)Cl.[C-]#[N+]CC(=O)OC>>CCCCCc1ocnc1C(=O)OC,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20060209587A1,C=CCc1ccc(C2OCC(C)(C)CO2)cc1.CC(O)=S>>CC(=O)SCCCc1ccc(C2OCC(C)(C)CO2)cc1,,Cc1ccccc1,,,,val
US04959349,CC1(C)CC(CO)c2ccccc21>>CC1(C)CC(CO)C2CCCCC21,,CCO,,[H][H],,val
US04808584,CCOC(=O)C(C(=O)OCC)=C(Nc1ccc(F)c(F)c1F)SCc1ccc(OC)cc1>>CCOC(=O)c1c(SCc2ccc(OC)cc2)nc2c(F)c(F)c(F)cc2c1O,,c1ccc(Oc2ccccc2)cc1,,CCCCCC,,val
US20110309300A1,CCCCC1CCC(O)(c2ccc(OCC)c(F)c2F)C1>>CCCCC1C=C(c2ccc(OCC)c(F)c2F)CC1,,O,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US20120129852A1,N#Cc1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C2CCCN(C(=O)NCc3ccccc3)C2)cc1=O.O=P(Cl)(Cl)Cl>>N#Cc1c(Cl)cc(C2CCCN(C(=O)NCc3ccccc3)C2)nc1-c1ccc(Oc2ccccc2)cc1,,CN(C)C=O,,,,val
US20140142083A1,CN1CCC(=O)CC1.COC(=O)c1cc(Br)cc(N)c1C>>COC(=O)c1cc(Br)cc(NC2CCN(C)CC2)c1C,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20010011090A1,Cn1nc(-c2ccc(C(=O)Cl)s2)cc1C(F)(F)F.Nc1nccs1>>Cn1nc(-c2ccc(C(=O)Nc3nccs3)s2)cc1C(F)(F)F,,O,,ClCCl,O=C([O-])O.[Na+],val
US20150291577A1,Cc1sc(C(=O)Nc2cnn(C)c2)cc1[C@@H]1C[C@H]1NC1CCC1.Cl>>Cc1sc(C(=O)Nc2cnn(C)c2)cc1[C@@H]1C[C@H]1NC1CCC1.Cl,,CCOC(C)=O,,,,val
US20110124665A1,COc1ccc(-c2c(-c3ccccc3)oc3ncnc(OCC4(COCC(=O)OC(C)(C)C)CCC4)c23)cc1>>COc1ccc(-c2c(-c3ccccc3)oc3ncnc(OCC4(COCC(=O)O)CCC4)c23)cc1,,C1COCCO1,,Cl,,val
US20090233928A1,C[C@H](O)C(=O)O.Cc1ncc(-c2nc(Nc3ccc(N4CCNCC4)cn3)ncc2F)n1C1CCCC1>>Cc1ncc(-c2nc(Nc3ccc(N4CCN(C(=O)[C@H](C)O)CC4)cn3)ncc2F)n1C1CCCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06649643B1,CC(C)C(O)(c1ccc2cc(OS(=O)(=O)C(F)(F)F)ccc2c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.CCCC[Sn](CCCC)(CCCC)c1ccco1>>CC(C)C(O)(c1ccc2cc(-c3ccco3)ccc2c1)c1c[nH]cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,[Cl-].[Li+],,val
US20140031391A1,CCOC(=O)c1ccc2c(n1)CCCC2NCCc1cc(F)ccc1OCc1ccc(CCc2ccc(C(F)(F)F)cc2)cc1.COC(=O)c1ccc(CCI)cc1>>CCOC(=O)c1ccc2c(n1)CCCC2N(CCc1ccc(C(=O)OC)cc1)CCc1cc(F)ccc1OCc1ccc(CCc2ccc(C(F)(F)F)cc2)cc1,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20050107449A1,CON(C)C(=O)c1sc(-c2ccc(C(F)(F)F)cc2)nc1C(C)C.C[Mg]Br>>CC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)nc1C(C)C,,C1CCOC1,,,,val
US20110071152A1,CCOC=C=C(C#N)C(=O)OCC.Cc1ccc(C(=O)O)cc1NN>>CCOC(=O)c1cnn(-c2cc(C(=O)O)ccc2C)c1N,,CCO,,CCN(CC)CC,Cl,val
US20070213338A1,COc1nnc(OCc2cccc(CNCCc3ccccc3)n2)c2ccccc12>>Oc1nnc(OCc2cccc(CNCCc3ccccc3)n2)c2ccccc12,,ClCCl,,Cl,,val
US20120208844A1,CCOC(=O)/C=C/c1ccccc1C1(C#N)CCN(C(=O)OC(C)(C)C)CC1>>CCOC(=O)CCc1ccccc1C1(C#N)CCN(C(=O)OC(C)(C)C)CC1,,CO,,,,val
US05292719,CC(C)(Cl)CCC(C)(C)Cl.COc1cccc(C)c1>>COc1cc(C)cc2c1C(C)(C)CCC2(C)C,Cl[Ti](Cl)(Cl)Cl,,,ClCCl,,val
US20100317568A1,COC(=O)N[C@H](C(=O)N1CCC[C@@]1(C(N)=O)c1ccc(-c2ccc(-c3ccc([C@]4(C(N)=O)CCCN4C(=O)[C@@H](NC(=O)OC)C(C)C)cc3)n2-c2ccc(F)cc2)cc1)C(C)C.O=C1CCC(=O)N1Br>>COC(=O)N[C@H](C(=O)N1CCC[C@@]1(C(N)=O)c1ccc(-c2c(Br)cc(-c3ccc([C@]4(C(N)=O)CCCN4C(=O)[C@@H](NC(=O)OC)C(C)C)cc3)n2-c2ccc(F)cc2)cc1)C(C)C,,ClCCl,,,,val
US20060247250A1,COc1ccc(Cl)c(C(=O)Nc2cnc(Nc3ccc(C(=O)NCCN4CCCC4)nc3)nc2)c1>>O=C(NCCN1CCCC1)c1ccc(Nc2ncc(NC(=O)c3cc(O)ccc3Cl)cn2)cn1,,ClCCl,,BrB(Br)Br,,val
US20100305109A1,Nn1cnc2ccccc2c1=O.O=C(Cl)CC12CC3CC(CC(C3)C1)C2>>O=C(CC12CC3CC(CC(C3)C1)C2)Nn1cnc2ccccc2c1=O,,ClC(Cl)Cl,,c1ccncc1,,val
US20110184188A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1cc(Cn2nc(C(F)(F)C(F)(F)F)cc2O)ccc1[N+](=O)[O-]>>Cc1cc(Cn2nc(C(F)(F)C(F)(F)F)cc2S)ccc1[N+](=O)[O-],,Cc1ccccc1,,,,val
US20160168100A1,COc1cc(C)c(/C=C/C2NCCc3cc(OCc4ccccc4)c(OC)cc32)cc1OCc1ccccc1.O=C(O)c1cnccn1>>COc1cc(C)c(/C=C/C2c3cc(OC)c(OCc4ccccc4)cc3CCN2C(=O)c2cnccn2)cc1OCc1ccccc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060041128A1,Cc1ccc(C(=O)Cl)cc1.Cc1nsc2nc(C(NCCNC(=O)OC(C)(C)C)C(C)C)n(Cc3ccccc3)c(=O)c12>>Cc1ccc(C(=O)N(CCNC(=O)OC(C)(C)C)C(c2nc3snc(C)c3c(=O)n2Cc2ccccc2)C(C)C)cc1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20020052349A1,CSc1ccc(N)cc1.Fc1ccc(CBr)cc1>>CSc1ccc(NCc2ccc(F)cc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20110201641A1,[N-]=[N+]=NC1CCc2cc3ccccc3n2C1>>NC1CCc2cc3ccccc3n2C1,[Pd],CO,,,,val
US20080275085A1,Cc1cc(F)ccc1[C@@H]1CNCC[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cc1nsc(Cl)n1.Cl>>Cc1nsc(N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3C)C2)n1.Cl,,C1CCOC1,,CCN(CC)CC,O,val
US05063228,CN1CC(CCCl)c2nc3ccccc3n2C1=O.c1ccc(N2CCNCC2)nc1>>CN1CC(CCN2CCN(c3ccccn3)CC2)c2nc3ccccc3n2C1=O,,Cc1ccccc1,,CCN(CC)CC,,val
US20100331295A1,CC(C)(C)OC(=O)C(C)(C)Oc1cccc(-c2ccc(-c3cc(C(F)(F)F)nn3-c3ccccc3Cl)s2)c1>>CC(C)(Oc1cccc(-c2ccc(-c3cc(C(F)(F)F)nn3-c3ccccc3Cl)s2)c1)C(=O)O,,ClCCl,,O=CO,,val
US20120115848A1,CC[C@@H]1c2nncn2-c2cnc(-c3ccnc(O)c3)nc2N1C1CCCC1.COP(=O)(OC)OC>>CC[C@@H]1c2nncn2-c2cnc(-c3ccn(C)c(=O)c3)nc2N1C1CCCC1,,C1COCCO1,,C1CCC2=NCCCN2CC1,,val
US20130203804A1,O=C(O)/C=C\C(=O)O.O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1>>O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1.O=C([O-])/C=C\C(=O)[O-],,CC(=O)OC(C)C,,,,val
US20090111807A1,COCOc1ccc(-c2ccc3c(c2CN(C(=O)OCC2c4ccccc4-c4ccccc42)c2ccccc2OC)N(C)C(=O)C(C)(C)N3)c(OC)c1>>COc1cc(O)ccc1-c1ccc2c(c1CN(C(=O)OCC1c3ccccc3-c3ccccc31)c1ccccc1OC)N(C)C(=O)C(C)(C)N2,,C1COCCO1,CCOC(C)=O,Cl,,val
US05166214,CCCCCCCNCCCCCSc1nc(-c2ccccc2)c(-c2ccccc2)[nH]1.Cl>>CCCCCCCNCCCCCSc1nc(-c2ccccc2)c(-c2ccccc2)[nH]1.Cl,,CCOCC,,CCCCCC,,val
US20080207654A1,CCCCc1nc(C)n(CC2Cc3ccccc3O2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCCc1nc(C)n(CC2Cc3ccccc3O2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US05145483,CNc1ccc([N+](=O)[O-])cc1O.O=C(Cl)OCc1ccccc1>>CN(C(=O)OCc1ccccc1)c1ccc([N+](=O)[O-])cc1O,,C1COCCO1,,O=C([O-])[O-].[Ca+2],,val
US05554706,CCCCCCCCBr.COC(=O)c1ccc(O)cc1O>>CCCCCCCCOc1ccc(C(=O)OC)c(O)c1,,CCC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110172442A1,COC(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)C=Cc1ccccc1F>>CC(C)(C)OC(=O)NCCC[C@H](NC(=O)C=Cc1ccccc1F)C(=O)O,,CO,,[Na+].[OH-],,val
US20120101095A1,CCOC(=O)c1sc2nc(SC)nc(-c3cccc(C)n3)c2c1N>>CSc1nc(-c2cccc(C)n2)c2c(N)c(C(=O)O)sc2n1,,C1COCCO1,O,[Li+].[OH-],,val
US20110135671A1,CCCCOc1nc(N)c2nc(OC)n(CCCCCl)c2n1.CN1CCNCC1>>CCCCOc1nc(N)c2nc(OC)n(CCCCN3CCN(C)CC3)c2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20060154977A1,NC(=O)[C@@H](N)Cc1cccc(C(=O)O)c1.O=C1N=c2ccccc2=N1>>O=C(NC(Cc1ccccc1)C(=O)O)c1ccc2[nH]c(=O)[nH]c2c1,,CO,,CCO,[Na+].[OH-],val
US20060079687A1,CN(CCCNCc1cc(C(=O)c2ccccc2)ccc1[N+](=O)[O-])C1CCCCC1.N#CBr>>CN(CCCN1Cc2cc(C(=O)c3ccccc3)ccc2N=C1N)C1CCCCC1,,CCO,,,,val
US20080312085A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Clc1cccc(CNC2=NCCS2)c1Cl>>CC(C)(C)OC(=O)N1CCSC1=NCc1cccc(Cl)c1Cl,,ClCCl,,,,val
US20150133428A1,CI.O=C(OCc1ccccc1)C1CC(F)(F)C1>>CC1(C(=O)OCc2ccccc2)CC(F)(F)C1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20040242455A1,COc1ccc(C(N)=O)cc1S(=O)(=O)Cl>>COc1ccc(C#N)cc1S(=O)(=O)Cl,,CCOC(C)=O,,CN(C)C=O,O=S(Cl)Cl,val
US20050113397A1,COC(=O)C(C(C)=O)c1cccc(C#N)c1.N#CCc1nc2ccccc2[nH]1>>CC1=C(C#N)c2nc3ccccc3n2C(=O)C1c1cccc(C#N)c1,,CO,ClC(Cl)Cl,C,O=C[O-].[NH4+],val
US03966783,O=C(Cl)CCCC(=O)c1ccccc1.[Fe+2].c1cc[cH-]c1.c1cc[cH-]c1>>O=C(CCCC(=O)[c-]1cccc1)c1ccccc1.[Fe+2].c1cc[cH-]c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20090018103A1,CC(C)(C)OC(=O)N1CCC[C@@H](C(=O)c2cccc(Cl)c2)C1.CC(F)(F)CCC[Mg]Cl>>CC(F)(F)CCC[C@@](O)(c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,,,val
US20150218141A1,COc1ccc(C2CCCNC2)cc1.FC(F)(F)[C@@H]1CO1>>COc1ccc(C2CCCN(C[C@H](O)C(F)(F)F)C2)cc1,,CC#N,,,,val
US06541491B1,C=CCOC(=O)N1C[C@@H](S)C[C@H]1CNC(=O)c1ccc(C(=O)OCC)s1.NCc1ccc(Cl)c(Cl)c1>>CCOC(=O)c1ccc(C(=O)NCc2ccc(Cl)c(Cl)c2)s1,,CC#N,,CCN(CC)CC,,val
US20080058486A1,COc1ccccc1P(Cl)c1ccccc1>>COc1ccccc1Pc1ccccc1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140080788A1,CCOC(=O)CO.Clc1ncc(Br)cn1>>CCOC(=O)COc1ncc(Br)cn1,,CCOC(C)=O,Cc1ccccc1,[H-].[Na+],,val
US20140162971A1,O=C(O)c1cnc(Cl)c(Br)c1.Oc1ccc(F)cc1F>>O=C(O)c1cnc(Oc2ccc(F)cc2F)c(Br)c1,,CS(C)=O,O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20100113458A1,CN.N#Cc1cc([N+](=O)[O-])cc(S(=O)(=O)Cl)c1>>CNS(=O)(=O)c1cc(C#N)cc([N+](=O)[O-])c1,,ClCCl,,,,val
US20040077852A1,CS(=O)(=O)Cl.O=[N+]([O-])c1ccc(N2CCC(O)C2)cc1>>CS(=O)(=O)OC1CCN(c2ccc([N+](=O)[O-])cc2)C1,,C1CCOC1,,CCN(CC)CC,,val
US20060189629A1,C1CCOC1.CN(C)C=O.O=C(NCc1cccnc1)c1ccc2c(c1)ncn2-c1ccc(O)cc1>>O=C(NCc1cccnc1)c1ccc2c(c1)ncn2-c1ccc(OCc2cccnc2)cc1,,CN(C)C=O,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080146582A1,CN1C2CCC1CN(c1ccc(C#Cc3ccc(N)cc3)nn1)C2.O=C(Cl)c1ccccc1>>CN1C2CCC1CN(c1ccc(C#Cc3ccc(NC(=O)c4ccccc4)cc3)nn1)C2,,ClCCl,,[Na+].[OH-],,val
US20080009477A1,NC1CC1c1ccccc1.O=C=Nc1cccc(OC(F)F)c1>>O=C(Nc1cccc(OC(F)F)c1)NC1CC1c1ccccc1,,CCCCCC,,,,val
US20060094707A1,COC(=O)c1c(F)cccc1[N+](=O)[O-]>>COC(=O)c1c(N)cccc1F,[Fe],CC(=O)O,CCO,,,val
US20150011773A1,CC(C)(C)OC(=O)N[C@@H](C[C@H](Cc1ccc(O)cc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.FCCCI>>CC(C)(C)OC(=O)N[C@@H](C[C@H](Cc1ccc(OCCCF)cc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040043987A1,CCB(CC)c1cccnc1.Nc1cc(Br)ccc1S(N)(=O)=O>>Nc1cc(-c2cccnc2)ccc1S(N)(=O)=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US04968711,CC(=O)N[C@@H](CS)C(=O)O.CO>>CC(=O)N(C)[C@@H](CS)C(=O)O,Cl,,,,,val
US20050070582A1,CI.Cc1cc(C)cc(Oc2ccc(O)cc2S(=O)(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1>>COc1ccc(Oc2cc(C)cc(C)c2)c(S(=O)(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US08575156B2,C=CCC1(c2ccc(F)cc2)CCNC(=O)O1.ClCc1ccc(Cl)cc1Cl>>C=CCC1(c2ccc(F)cc2)CCN(Cc2ccc(Cl)cc2Cl)C(=O)O1,,CN(C)C=O,,[H-].[Na+],,val
US20050020605A1,CCON=C(c1ccc(Br)cc1)C1CCN(C2(C)CCNCC2)CC1.CCn1c(C(=O)O)cc2ccccc21>>CCON=C(c1ccc(Br)cc1)C1CCN(C2(C)CCN(C(=O)c3cc4ccccc4n3CC)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccsc4)nc(Cl)c3n2)cc1.Nc1ccc2cn[nH]c2c1>>c1cc(-c2nc(Nc3ccc4cn[nH]c4c3)c3[nH]ncc3n2)cs1,C1COCCO1,CO,,Cl,,val
US20150087600A1,NC(=O)OCc1ccccc1.O=C1C=CCC1>>O=C1CCC(NC(=O)OCc2ccccc2)C1,,ClCCl,,,,val
US20120053166A1,Cc1ccc(S(=O)(=O)n2ncc3c(-c4nnn[nH]4)cc(-c4cnc(Cl)c(NS(C)(=O)=O)c4)cc32)cc1.O=C(Cl)CCl>>Cc1ccc(S(=O)(=O)n2ncc3c(-c4nnc(CCl)o4)cc(-c4cnc(Cl)c(NS(C)(=O)=O)c4)cc32)cc1,,Cc1ccccc1,,,,val
US06384041B1,CCc1cc2c(OCC(=O)OC)nc(SC)nc2n1Cc1cccc(F)c1.O=C(Cl)C(=O)Cl.c1ccncc1>>CCc1c(C(=O)C(N)=O)c2c(OCC(=O)OC)nc(SC)nc2n1Cc1cccc(F)c1,,ClC(Cl)Cl,,,,val
US20160052896A1,O=C(NCCCNc1ccnc(Cl)n1)c1cc(-c2ccccc2)on1>>NC(=O)c1cc(-c2ccccc2)on1,,CC(C)O,,C1COCCN1,,val
US04931560,O=S(Br)Br.OCc1cc(C2CC2)nc(Nc2ccccc2)n1>>BrCc1cc(C2CC2)nc(Nc2ccccc2)n1,,CCOCC,O,c1ccncc1,O=C([O-])O.[Na+],val
US20080207616A1,CC(C)(C#N)c1cccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)c1>>CC(C)(C#N)c1cccc(C(=O)Nc2ccc(F)c(N)c2)c1,[Fe],CO,O,[Cl-].[NH4+],,val
US20060293310A1,CNC(=O)COC(=O)N1CCCN(c2ccc(Br)cn2)CC1.OB(O)c1ccc(OC(F)(F)F)cc1>>CNC(=O)COC(=O)N1CCCN(c2ccc(-c3ccc(OC(F)(F)F)cc3)cn2)CC1,,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US06307056B1,Nc1cccc(-c2cccc3c2/C(=C/c2ccc[nH]2)C(=O)N3)c1.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>O=C1Nc2cccc(-c3cccc(NC(=O)c4ccc([N+](=O)[O-])cc4)c3)c2/C1=C/c1ccc[nH]1,,ClC(Cl)Cl,,CCN(CC)CC,Cl,val
US07071175B1,CC(C)(C)OC(=O)Nc1cc(CBr)ccn1.CCOC(=O)CC(=O)OCC>>CCOC(=O)C(Cc1ccnc(NC(=O)OC(C)(C)C)c1)C(=O)OCC,,C1CCOC1,,[H-].[Na+],,val
US04898854,CCOP(=O)(Cc1cc[n+]([O-])c2ccccc12)OCC.C[Si](C)(C)C#N>>CCOP(=O)(Cc1cc(C#N)nc2ccccc12)OCC,,CCN(CC)CC,,,,val
US20150191478A1,O=C1CSC(=S)N1.O=Cc1cc2cncc(C#CC3CC3)c2o1>>O=C1NC(=S)S/C1=C\c1cc2cncc(C#CC3CC3)c2o1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20040122033A1,O=C1CCCCCCCCC1.[N-]=[N+]=[N-]>>O=C1CCCCCCCCCN1,,O,O=S(=O)(O)O,[Na+].[OH-],,val
US20030236287A1,COc1cc(OC)c(Br)cc1N.O=C(Cl)Cl>>COc1cc(OC)c(N=C=O)cc1Br,,CCOC(C)=O,,,,val
US20090264428A1,C1CCOC1.CCO.COC(=O)[C@@H]1C[C@H](O)[C@H](NC(=O)OC(C)(C)C)C1>>CC(C)(C)OC(=O)N[C@@H]1C[C@@](C(=O)O)(C(C)(C)C)C[C@@H]1O,,C1CCOC1,CCO,[Na+].[OH-],,val
US20120238599A1,C=COCCONC(=O)c1c(Nc2ccc(I)cc2F)n(C)c(=O)c2cc(C)oc12>>Cc1cc2c(=O)n(C)c(Nc3ccc(I)cc3F)c(C(=O)NOCCO)c2o1,,CO,,Cl,,val
US05783591,CCOc1cc(C2(C)CNC(=O)O2)ccc1OC.CI>>CCOc1cc(C2(C)CN(C)C(=O)O2)ccc1OC,,C1CCOC1,,[K+].[OH-],,val
US20140073620A1,Cc1nn(C)cc1N.NC(=O)C1(c2ccccc2CCc2nc(Cl)ncc2Cl)CC1>>Cc1nn(C)cc1Nc1ncc(Cl)c(CCc2ccccc2C2(C(N)=O)CC2)n1,,C1COCCO1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20040122016A1,CC(C)(C)OC(=O)Nc1csc(-c2ccncc2)n1>>Nc1csc(-c2ccncc2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030233002A1,CC(C)(C)OC(=O)Nc1ccc2c(c1)CCC(O)O2.CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)CC1CCc2cc(NC(=O)OC(C)(C)C)ccc2O1,,Cc1ccccc1,,C,C[O-].[Na+],val
US06815465B1,C[C@H]1C[C@@H](C)C[C@H](C)[C@@H](O)C(C#N)=CC=CC[C@@H]([C@@H]2CCC[C@H]2C(=O)O)OC(=O)C[C@H](O)[C@@H](C)C1.Nc1cccnc1>>C[C@H]1C[C@@H](C)C[C@H](C)[C@@H](O)C(C#N)=CC=CC[C@@H]([C@@H]2CCC[C@H]2C(=O)O)OC(=O)C[C@H](O)[C@@H](C)C1.[NH-]c1cccnc1,,CO,ClC(Cl)Cl,,,val
US20120046268A1,C[C@H]1CNC[C@@H](C)O1.O=C(NC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)Oc2ccc([N+](=O)[O-])cc2)C1)c1ccccc1>>CC1CN(C(=O)N2CC(NC(=O)c3ccccc3)CC(c3ccc(C(F)(F)F)cc3)C2)CC(C)O1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05215982,CN(C)C(=O)Cl.c1cc2[nH]ccn2n1>>CN(C)C(=O)n1ccn2nccc12,,C1CCOC1,O,CCN(CC)CC,CCOC(C)=O,val
US20030144288A1,CCCC[Sn](CCCC)(CCCC)C1=CCCCC1.COc1ccc(Br)cc1[N+](=O)[O-]>>COc1ccc(C2=CCCCC2)cc1[N+](=O)[O-],c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20090029988A1,CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)CS(C)(=O)=O>>CC(C)(Cn1c(CO)nc2c(N)nc3ccccc3c21)CS(C)(=O)=O,,ClCCl,,BrB(Br)Br,,val
US05726319,CNc1ccc(-c2ccccc2C#N)cc1.O=C(N[C@H](CCc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21>>CN(C(=O)[C@H](N)CCc1ccccc1)c1ccc(-c2ccccc2C#N)cc1,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20070072896A1,CN1CC(c2cn(COCC[Si](C)(C)C)c3ncc(CC4CCC(=O)CC4)cc23)=CN1>>CN1CC(c2c[nH]c3ncc(CC4CCC(=O)CC4)cc23)=CN1,,CCO,,Cl,,val
US20150322056A1,CC(C)N=C(NC(C)C)OC(C)(C)C.COc1ccc(CN(CC(C)Cl)C(=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C(=O)O)cc1>>COc1ccc(CN(CC(C)Cl)C(=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C(=O)OC(C)(C)C)cc1,,C1CCOC1,,,,val
US20090042929A1,CC(C)N.O=C(O)c1ccc(OCC(=O)C23CC4CC(CC(C4)C2)C3)cc1>>CC(C)NC(=O)c1ccc(OCC(=O)C23CC4CC(CC(C4)C2)C3)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US20090291937A1,CCC(C)(CNC(=O)OC(C)(C)C)c1cccc(B2OC(C)(C)C(C)(C)O2)c1.Clc1n[nH]c2nccc(I)c12>>CCC(C)(CNC(=O)OC(C)(C)C)c1cccc(-c2ccnc3[nH]nc(Cl)c23)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20100331320A1,C=C(C)CC(O)(CCCl)c1ccccc1.C[C@H](N)c1ccc(Br)cc1>>C=C(C)CC(O)(CCN[C@@H](C)c1ccc(Br)cc1)c1ccccc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160129001A1,CC(C)(C)OC(=O)N1CCC(N)CC1.Cc1nnc2c(Cl)nc(Br)cn12>>Cc1nnc2c(NC3CCN(C(=O)OC(C)(C)C)CC3)nc(Br)cn12,,C1CCOC1,O,,,val
US20120059030A1,CC1(C)OB(c2ccc(C#N)cc2F)OC1(C)C.Cc1cc(Br)ccn1>>Cc1cc(-c2ccc(C#N)cc2F)ccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090111809A1,CC(C)[Si](OC1CCN(N2CC[C@@H](Cc3c(Cl)cc(O)cc3Cl)C2=O)CC1)(C(C)C)C(C)C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)[Si](OC1CCN(N2CC[C@@H](Cc3c(Cl)cc(OS(=O)(=O)C(F)(F)F)cc3Cl)C2=O)CC1)(C(C)C)C(C)C,,ClCCl,,c1ccncc1,,val
US20110143937A1,Cc1ccc(S(=O)(=O)C#N)cc1.O=c1oc(Cc2cccc(Cl)c2)ns1>>Cc1ccc(S(=O)(=O)c2nc(Cc3cccc(Cl)c3)ns2)cc1,,Clc1ccccc1Cl,,,,val
US20090275606A1,Cc1c(=O)n2c(c3[nH]c(=O)n(-c4ccc(Br)cc4F)c13)CCC2.O=S(=O)(Cl)C1CC1>>Cc1c(=O)n2c(c3c1n(-c1ccc(Br)cc1F)c(=O)n3S(=O)(=O)C1CC1)CCC2,,CN(C)C=O,ClC(Cl)Cl,CO,[H-].[Na+],val
US05482971,CC(Cc1ccc(O)c(O)c1)N1CC(c2cccc(Cl)c2)OC1=O.O=C(CBr)CBr>>CC(CC1CCC2=C(CC(=O)CO2)OC1)N1CC(c2cccc(Cl)c2)OC1=O,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090105305A1,CCOC(=O)c1ccc(C#N)c(N)c1>>N#Cc1ccc(C(=O)O)cc1N,,C1CCOC1,O,[Li+].[OH-],,val
US04714774,CC(=O)OC(C)=O.CCCc1c(OCCCOc2ccc(C(=O)O)cc2Br)ccc(C(C)=O)c1O>>CCCc1c(OCCCOc2ccc(C(=O)O)cc2Br)ccc(C(C)=O)c1OC(C)=O,,c1ccncc1,,,,val
US20020169266A1,C=CC(=O)Cl.CC1(O)C2CC3CC(O)(C2)CC1(O)C3>>C=CC(=O)OC1(C)C2CC3CC(O)(C2)CC1(O)C3,,O,,C1CCOC1,CCN(CC)CC,val
US20140194432A1,CCOC(=O)C(=CN(C)C)C(=O)c1ncccc1F.NCc1ccccc1-c1ccccc1>>CCOC(=O)c1cn(Cc2ccccc2-c2ccccc2)c2cccnc2c1=O,,CC(=O)N(C)C,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20130338190A1,CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/[C@H]1CCCN1C.Cl.ClCCl>>CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/[C@H]1CCCN1C.Cl.Cl,,ClCCl,,CCOCC,,val
US20090215843A1,CCOC(=O)CCCCC(/C=C/c1ccccc1OCc1ccc(C(C)(C)C)cc1)CCc1ccc(C#N)cc1.C[Si](C)(C)N=[N+]=[N-]>>CCOC(=O)CCCCC(/C=C/c1ccccc1OCc1ccc(C(C)(C)C)cc1)CCc1ccc(-c2nnn[nH]2)cc1,,Cc1ccccc1,,CCCC[Sn](=O)CCCC,,val
US04165365,O=C(O)C(=O)C(=O)Nc1cccc([N+](=O)[O-])c1>>Nc1cccc(NC(=O)C(=O)C(=O)O)c1,[Pd],CO,,,,val
US20040072858A1,C#CCOCCn1cnc2cnc3ccccc3c21.Ic1cccs1>>C(#Cc1cccs1)COCCn1cnc2cnc3ccccc3c21,[Cu]I,CN(C)C=O,,CCN(CC)CC,,val
US20040106667A1,CS(=O)(=O)c1ccccc1S(=O)(=O)Cl.C[Si](C)(C)CCOCn1nc(Sc2ccccc2)c2cc(N)ccc21>>C[Si](C)(C)CCOCn1nc(Sc2ccccc2)c2cc(NS(=O)(=O)c3ccccc3S(C)(=O)=O)ccc21,,c1ccncc1,,,,val
US04920133,COC(=O)c1cccc(Cc2ccc(O)cc2)c1.ClCc1ccc2ccccc2n1>>COC(=O)c1cccc(Cc2ccc(OCc3ccc4ccccc4n3)cc2)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110251186A1,[N-]=[N+]=NC1(CCO)c2cc(Br)ccc2Oc2c1cc(Cl)nc2F>>NC1(CCO)c2cc(Br)ccc2Oc2c1cc(Cl)nc2F,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06184225B2,COC(=O)Oc1cc(Nc2ncnc3cc(N)ccc23)c(F)cc1C.COCC(=O)Cl>>COCC(=O)Nc1ccc2c(Nc3cc(OC(=O)OC)c(C)cc3F)ncnc2c1,,ClCCl,,CCN(CC)CC,Cl,val
US20100075948A1,CN(C)C[C@H](O)COC(C)(C)Cn1ccc([N+](=O)[O-])n1>>CN(C)C[C@H](O)COC(C)(C)Cn1ccc(N)n1,[Pd],CCO,,CCOC(C)=O,[H][H],val
US20100311777A1,COC(=O)C1(N)CCN(OC)CC1.Cc1cc(C)c(C2CC2)cc1CC(=O)Cl>>COC(=O)C1(NC(=O)Cc2cc(C3CC3)c(C)cc2C)CCN(OC)CC1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US04829061,CC(C)(C)c1cc(C(=O)N2CCCN(C(=O)OCc3ccccc3)CC2)cc(C(C)(C)C)c1O>>CC(C)(C)c1cc(C(=O)N2CCCNCC2)cc(C(C)(C)C)c1O,[Pd],CC(=O)O,,[H][H],,val
US06562827B1,COC(=O)c1cccnc1Cl.c1ccc(CN2CCNCC2)cc1>>COC(=O)c1cccnc1N1CCN(Cc2ccccc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110172245A1,CC(C)(C)OC(=O)Nc1cccc(Oc2ccc3nc(N)[nH]c3c2)c1.O=C(Cl)C1CC1>>CC(C)(C)OC(=O)Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)[nH]c3c2)c1,CN(C)c1ccncc1,c1ccncc1,,CO,[Na+].[OH-],val
US20090099243A1,CCC1(c2ccccc2)NC(=O)N(Cc2ccc(N)cc2)C1=O.Cc1noc(C)c1C(=O)O>>CCC1(c2ccccc2)NC(=O)N(Cc2ccc(NC(=O)c3c(C)noc3C)cc2)C1=O,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05418232,CC1(C)C2C(=O)OC(=O)C21.CNN>>CN1NC(=O)C2C(C1=O)C2(C)C,,CCO,,,,val
US04963590,CC(=O)c1ccc(C)cc1.O=Cc1cc(O)c(O)c([N+](=O)[O-])c1>>Cc1ccc(C(=O)C=Cc2cc(O)c(O)c([N+](=O)[O-])c2)cc1,,C1CCOC1,,Cl,,val
US20160160359A1,C=C[Si](OC)(OC)OC.C=Cc1ncc[nH]1>>C=C[Si](OC)(OC)OC.C=Cc1ncc[nH]1,,CC(C)O,,,,val
US08609849B1,CC(C)(C#N)C(O)c1ccccc1F>>CC(C)(CN)C(O)c1ccccc1F,,C1CCOC1,,B,,val
US20140148474A1,CCOC(=O)C1CCC(=Cc2ncc(Br)s2)CC1.Cc1cc(Nc2nccc(C)n2)cc(B2OC(C)(C)C(C)(C)O2)c1>>CCOC(=O)C1CCC(=Cc2ncc(-c3cc(C)cc(Nc4nccc(C)n4)c3)s2)CC1,,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US05627193,CC(=O)C(=O)O.Cc1ccc(N)cc1.O=Cc1ccccc1>>Cc1ccc2nc(-c3ccccc3)cc(C(=O)O)c2c1,,CCO,,,,val
US03966736,CI.CN(C)CC(=O)N1c2ccccc2-n2c(n[nH]c2=O)-c2cccnc21>>CN(C)CC(=O)N1c2ccccc2N2CN(C)N=C2c2cccnc21,,CN(C)C=O,,[H-].[Na+],,val
US03951640,CNc1nnc(S(C)(=O)=O)s1.O=C(Cl)Cl>>CN(C(=O)Cl)c1nnc(S(C)(=O)=O)s1,,c1ccccc1,,,,val
US20030232852A1,CC(C)(O)CN.Cc1nc(Cl)c([N+](=O)[O-])c(Cl)c1C>>Cc1nc(Cl)c([N+](=O)[O-])c(NCC(C)(C)O)c1C,,CN(C)C=O,,CCN(CC)CC,,val
US20150329538A1,CC(C)(C)OC(=O)N1CCC[C@H](N)C1.O=C1NCCc2[nH]c(-c3cccc4ccc(Cl)nc34)cc21>>CC(C)(C)OC(=O)N1CCC[C@H](Nc2ccc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)C1,,CS(C)=O,,,,val
US06936602B1,COC(=O)C1=Cc2cc(Br)ccc2NCC1.Clc1cccs1.O.c1ccncc1>>COC(=O)C1=Cc2cc(Br)ccc2N(C(=O)c2cccs2)CC1,,C1CCOC1,,,,val
US20100298330A1,COC(=O)c1ccc(OC/C(F)=C\CN)cc1.Cl>>Cl.[NH3+]C/C=C(/F)COc1ccc(C(=O)[O-])cc1,,Cl,,,,val
US20140179666A1,C[C@@H]1CN(CC(=O)OCc2ccccc2)[C@@H](CN2CC[C@@H](F)C2)CN1C(=O)OC(C)(C)C>>C[C@@H]1CN(CC(=O)O)[C@@H](CN2CC[C@@H](F)C2)CN1C(=O)OC(C)(C)C,,CCO,,,,val
US20050222151A1,OCc1cncc(Br)c1>>O=Cc1cncc(Br)c1,O=[Mn]=O,,,,,val
US20070105866A1,CCOC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCc3nc4ccccc4s3)ccc2n1Cc1ccc(-c2ccc(OC)nc2)cc1>>CCOC(=O)C(C)(C)Cc1cc2cc(OCc3nc4ccccc4s3)ccc2n1Cc1ccc(-c2ccc(OC)nc2)cc1,,ClCCl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20150166480A1,C=O.CC(C)(F)CN1CCC(CNc2ccc(-c3ccc(C(=O)N4CCC[C@@H](O)C4)cc3)cc2)CC1>>CN(CC1CCN(CC(C)(C)F)CC1)c1ccc(-c2ccc(C(=O)N3CCC[C@@H](O)C3)cc2)cc1,,CC#N,,CC(=O)O,[BH3-]C#N.[Na+],val
US20040116697A1,CI.CSc1nc(-c2ccccc2F)c2ccc(=O)[nH]c2n1>>CSc1nc(-c2ccccc2F)c2ccc(=O)n(C)c2n1,,C1CCOC1,,[H-].[Na+],,val
US20040063645A1,CCOC(=O)c1cc2cc(C(=O)NCCNC(=O)OC(C)(C)C)ccc2[nH]1>>CC(C)(C)OC(=O)NCCNC(=O)c1ccc2[nH]c(C(=O)O)cc2c1,,CO,,[Na+].[OH-],,val
US20120220575A1,Cc1ccc(C#N)c(CN2CC3COCCN3c3nc(Cl)ncc32)c1.O=S(=O)(O)O>>Cc1ccc(C(N)=O)c(CN2CC3COCCN3c3nc(Cl)ncc32)c1,,CCOC(C)=O,,,,val
US20070224130A1,CCC1(CC(O)(CO)C(F)(F)F)CCCc2ccccc21>>CCC1(CC(O)(C=O)C(F)(F)F)CCCc2ccccc21,,CS(C)=O,ClCCl,CCN(CC)CC,[Cl-].[NH4+],val
US04299992,C=O.Cc1ccccc1[N+](=O)[O-]>>O=[N+]([O-])c1ccccc1CCO,,CN(C)C=O,O,[K+].[OH-],,val
US20070265301A1,CCOC(=O)CC(Cc1cc(F)ccc1F)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NC(CC(=O)O)Cc1cc(F)ccc1F,,C1CCOC1,,Cl,[Li+].[OH-],val
US05216162,Clc1ccc2c(c1)ncc1c3c([nH]c12)CCNC3.N#Cc1ccc(F)cc1.O>>N#Cc1ccc(NCCc2[nH]c3c(cnc4cc(Cl)ccc43)c2C=O)cc1,,O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20020019548A1,CC(=O)O[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@@]1(C)CCC(=O)CC1=C[C@H]3C>>CC(=O)O[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@@]1(C)CC[C@H](O)CC1=C[C@H]3C,,C1CCOC1,CCO,CC(=O)O,[BH4-].[Na+],val
US05962465,Cc1ccc(S(=O)(=O)OC[C@H]2COc3ccc4c(c3O2)CC(=O)N4)cc1.NCCc1c[nH]c2ccccc12>>O=C1Cc2c(ccc3c2OC(CNCCc2c[nH]c4ccccc24)CO3)N1,,CS(C)=O,,,,val
US20160083379A1,CC(C)c1ccc(NC(=O)C(F)(F)F)cc1>>CC(C)c1ccc(NCC(F)(F)F)cc1,,C1CCOC1,,,,val
US20140163025A1,Cc1ccc(S(=O)(=O)OCCC(C)(C)O)cc1.c1ccc(COc2ccc3[nH]ncc3c2)cc1>>CC(C)(O)CCn1ncc2cc(OCc3ccccc3)ccc21,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120046419A1,C=C.C=CCCCCC=C.C=CCCCCCC>>C=C.C=CCCCCC=C.C=CCCCCCC,,Cc1ccccc1,,,,val
US20120122780A1,CCOC(=O)Cc1cccc2ccccc12.CCOC=O>>CC(=O)C(C=O)c1cccc2ccccc12,,CCOCC,,[Na],,val
US20030130213A1,N#Cc1nc(Cl)cnc1Cl.Oc1ccc(OCc2ccccc2)cc1>>N#Cc1nc(Cl)cnc1Oc1ccc(OCc2ccccc2)cc1,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20090131468A1,COC(=O)c1cncc(O)c1.O=C1CCC(=O)N1Cl>>COC(=O)c1cnc(Cl)c(O)c1,,CN(C)C=O,,,,val
US20150336960A1,COC(=O)N(C)[C@H]1[C@@H](C)CN(c2ccncc2N)C[C@H]1NC(=O)OC(C)(C)C.S=C(n1ccnc1)n1ccnc1>>COC(=O)N(C)[C@H]1[C@@H](C)CN(c2ccncc2N=C=S)C[C@H]1NC(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20050043388A1,CCCCCC(=O)Cl.COC(=O)c1ccc(N)cc1>>CCCCCC(=O)Nc1ccc(C(=O)OC)cc1,,c1ccncc1,,,,val
US20040209921A1,CN(C)S(=O)(=O)Cl.Cc1cnc(CN(CCCCNC(=O)OC(C)(C)C)Cc2ncccc2O)c(C)c1>>Cc1cnc(CN(CCCCNC(=O)OC(C)(C)C)Cc2ncccc2OS(=O)(=O)N(C)C)c(C)c1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US05356911,CCCCc1cc(C(=O)OC)cc(=O)[nH]1.N>>CCCCc1cc(C(N)=O)cc(=O)[nH]1,,CCO,,,,val
US20100273739A1,CCOC(=O)Cl.COc1ccc2c(c1)C(Cc1ccc(Cl)c(Cl)c1)C(N)CC2>>CCOC(=O)NC1CCc2ccc(OC)cc2C1Cc1ccc(Cl)c(Cl)c1,,c1ccncc1,,Cl,,val
US20150274767A1,C#C[C@]1(CO)O[C@@H](c2cnn3c(N)ncnc23)C[C@@H]1O[Si](C)(C)C(C)(C)C>>C#C[C@]1(CO)O[C@@H](c2cnn3c(N)ncnc23)C[C@@H]1O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080275056A1,Cc1ccc(-n2nc(C3(C)CC3)cc2NC(=O)Nc2cnc(OC3CCN(C(=O)OC(C)(C)C)CC3)c3ccccc23)cc1.Cl.ClCCl>>Cc1ccc(-n2nc(C3(C)CC3)cc2NC(=O)Nc2cnc(OC3CCNCC3)c3ccccc23)cc1.Cl.Cl,,ClCCl,,C1COCCO1,,val
US20090124682A1,COC(=O)C[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2cc(Cl)cc(F)c2[nH]1>>O=C(O)C[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2cc(Cl)cc(F)c2[nH]1,,CO,,[Na+].[OH-],,val
US20080171754A1,O=Cc1c(F)cccc1Cl.[OH-]>>O=Cc1c(O)cccc1Cl,,CS(C)=O,O,Cl,,val
US20120142679A1,C[C@@]1(C(F)(F)F)Cn2c(nc(N3CCOCC3)cc2=O)N1.Cc1ccccc1C(=O)Cl>>Cc1ccccc1C(=O)N1c2nc(N3CCOCC3)cc(=O)n2C[C@@]1(C)C(F)(F)F,,C1CCOC1,,[H-].[Na+],,val
US20090082393A1,CC(C)(C)OC(=O)CCO.O=S(=O)(c1ccccc1)c1no[n+]([O-])c1S(=O)(=O)c1ccccc1>>CC(C)(C)OC(=O)CCOc1no[n+]([O-])c1S(=O)(=O)c1ccccc1,,C1CCOC1,,[Na+].[OH-],,val
US20070254937A1,O=C(c1sc2ccccc2c1NN=C(c1ccccc1)c1ccccc1)c1nc2ccc(OCCCN3CCCCC3)cc2n1COCc1ccccc1>>c1ccc2c(c1)sc1c(-c3nc4ccc(OCCCN5CCCCC5)cc4[nH]3)n[nH]c12,,CCO,,Br,,val
US20020091272A1,CC(=O)OCc1c(C)cc(C)c(N)c1C.COCN(c1onc(C)c1C)S(=O)(=O)c1ccsc1C(=O)Cl>>COCN(c1onc(C)c1C)S(=O)(=O)c1ccsc1C(=O)Nc1c(C)cc(C)c(COC(C)=O)c1C,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20090075979A1,CCOC(=O)C[C@@H]1CC[C@@H](C(=O)OCc2ccccc2)CC1>>CCOC(=O)C[C@@H]1CC[C@@H](C(=O)O)CC1,[Pd],CO,,,,val
US20130023541A1,CCN(C(=O)OC(C)(C)C)[C@@H]1CCN(c2ncccc2C(=O)OC(C)C)C1>>CCN(C(=O)OC(C)(C)C)[C@@H]1CCN(c2ncccc2CO)C1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100093757A1,CC(C)(C)[Si](C)(C)OCCC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(C#N)cn1>>N#Cc1ccc(NC(=O)[C@H](CCCO)Oc2ncnc3c2cnn3-c2ncccc2Cl)nc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04163112,CN=C=O.COC(COc1ccc(O)cc1)OC>>CNC(=O)Oc1ccc(OCC(OC)OC)cc1,CCN(CC)CC,c1ccccc1,,,,val
US20140114068A1,Cc1cc2c(cc1C)C1(NC(=O)c3ccc4ncccc4c3)C(=O)c3c([N+](=O)[O-])cccc3C1(O)O2>>Cc1cc2c(cc1C)C1(NC(=O)c3ccc4ncccc4c3)C(=O)c3c(N)cccc3C1(O)O2,[Fe],CCO,,Cl,O,val
US20100273764A1,C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1.F[B-](F)(F)CBr.[K+]>>C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C[B-](F)(F)F.[K+],,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20130109682A1,CC[Si](CC)(CC)OS(=O)(=O)C(F)(F)F.O=[N+]([O-])c1cnccc1[C@H]1C[C@@H](NCc2ccccc2)[C@H](O)[C@@H](C2CC2)O1>>CC[Si](CC)(CC)O[C@H]1[C@H](NCc2ccccc2)C[C@H](c2ccncc2[N+](=O)[O-])O[C@@H]1C1CC1,,ClCCl,,CCN(CC)CC,,val
US20140080806A1,C1CNC1.Cc1ccc(-c2c(C(=O)c3c(Cl)ncnc3Cl)cnn2C)cc1>>Cc1ccc(-c2c(C(=O)c3c(Cl)ncnc3N3CCC3)cnn2C)cc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US06080743,COc1nc2cc(Br)cc(CBr)c2nc1OC.O>>COc1nc2cc(Br)cc(CO)c2nc1OC,,C1COCCO1,O,O=C([O-])[O-].[Ca+2],,val
US20160175289A1,C[C@@H](N)Cc1c[nH]c2ccccc12.O=S(=O)(OCC(F)F)C(F)(F)F>>C[C@H](Cc1c[nH]c2ccccc12)NCC(F)F,,CC(=O)OC(C)C,,CC(C)NC(C)C,,val
US20160060273A1,CCOC(=O)C1(CC)CCN(C2=NOC3(C2)CN(Cc2cc(OCC)c(-c4ccc(F)cc4Cl)c(OCC)c2)C3)CC1>>CCOc1cc(CN2CC3(CC(N4CCC(CC)(C(=O)O)CC4)=NO3)C2)cc(OCC)c1-c1ccc(F)cc1Cl,,CCO,,[Na+].[OH-],,val
US04038396,C=C(C)Cc1cc(CC(=C)C)cc(-c2nc3ncccc3o2)c1>>CC(C)Cc1cc(CC(C)C)cc(-c2nc3ncccc3o2)c1,[Pd],CO,,[H][H],,val
US20040220200A1,CCOC(=O)c1[nH]c(C)c(C(C)=O)c1C.CN(C)C(OC(C)(C)C)N(C)C>>CCOC(=O)c1[nH]c(C)c(C(=O)C=CN(C)C)c1C,,C1CCOC1,,,,val
US05422358,NC(=O)C(c1ccccc1)(c1ccccc1)C1CCCNC1.Oc1ccc(CCBr)cc1>>NC(=O)C(c1ccccc1)(c1ccccc1)C1CCCN(CCc2ccc(O)cc2)C1,,CC#N,,O=C([O-])O.[Na+],,val
US03974162,CCOC(=O)CNc1cc(Cl)nc(Cl)n1.NCc1ccc(Cl)cc1>>CCOC(=O)CNc1cc(Cl)nc(NCc2ccc(Cl)cc2)n1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20060094767A1,C[C@](O)(CO)Cn1cc([N+](=O)[O-])nc1Cl.O=C(Cl)N1CC=C(c2ccc(C(F)(F)F)cc2)CC1>>C[C@](O)(COC(=O)N1CC=C(c2ccc(C(F)(F)F)cc2)CC1)Cn1cc([N+](=O)[O-])nc1Cl,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,,val
US20010039344A1,COC(=O)C(CC1CCCC1)c1ccc(S(C)(=O)=O)c(S(C)(=O)=O)c1>>CS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)O)cc1S(C)(=O)=O,,C1CCOC1,,[Li+].[OH-],,val
US05736534,COc1cc2ncnc(N3CCc4ccc(N)cc43)c2cc1OC.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COc1cc2ncnc(N3CCc4ccc(NC(=O)C(F)(F)F)cc43)c2cc1OC,,ClCCl,,c1ccncc1,,val
US20100022795A1,CCCCCCCCCCCCCCC[C@@H](O)[C@@H](NC(C)=O)C(=O)OCC.Cl>>CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)C(=O)OCC.Cl,,CCO,,,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(C(=O)Nc3cccnc3)c(OC(C)=O)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(C(=O)Nc3cccnc3)c(O)c2)=C(C)C1=O,,CO,,O=C([O-])O.[Na+],,val
US06214882B1,COc1ccc(S(N)(=O)=O)cc1C(O)CN=[N+]=[N-]>>COc1ccc(S(N)(=O)=O)cc1C(O)CN,[Pd],CCO,,,,val
US20070203124A1,CCN=C=O.COc1ccc(N2CCN[C@@H](Cc3ccccc3)C2)cc1OC1CCCC1>>CCNC(=O)N1CCN(c2ccc(OC)c(OC3CCCC3)c2)C[C@@H]1Cc1ccccc1,,ClCCl,,,,val
US05830821,BrCc1ccc2ccccc2c1.CCOC(=O)C(C)C(=O)OCC>>CCOC(=O)C(C)(Cc1ccc2ccccc2c1)C(=O)OCC,,CCO,,[Na],,val
US20040158065A1,CC(=O)Cl.O=[N+]([O-])c1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1>>CC(=O)N(c1ccc(F)c(Cl)c1)c1ncnc2cc(OCCCN3CCOCC3)c([N+](=O)[O-])cc12,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120149699A1,COC(=O)c1ccc(S(=O)(=O)Cl)cc1.Cc1cccn2c(C)c(NC(=O)OC(C)(C)C)nc12>>COC(=O)c1ccc(S(=O)(=O)N(C(=O)OC(C)(C)C)c2nc3c(C)cccn3c2C)cc1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20100204240A1,CC(=O)[C@@H]1COC(C)(C)O1.NO>>CC1(C)OC[C@@H](C=NO)O1,,C1CCOC1,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20040137052A1,CCOC(=O)C(C)(C)c1cn2nc(NCCCN3CCC(OC(c4ccccc4)c4ccccc4)CC3)ccc2n1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CCOC(=O)C(C)(C)c1cn2nc(NCCCN3CCC(OC(c4ccccc4)c4ccccc4)CC3)ccc2n1.O=C(O)CC(O)(CC(=O)O)C(=O)O,,CCO,,O,,val
US20100261709A1,Cl.O=C(OCc1ccccc1)N1CCN([C@H]2CC[C@@H](F)C2)C(=O)C1>>O=C1C[NH2+]CCN1[C@H]1CC[C@@H](F)C1.[Cl-],[Pd],CO,,,,val
US05756524,COC(=O)Cl.O=C(O)c1ccc(Cl)nc1>>COC(=O)c1ccc(Cl)nc1,,ClCCl,,CCN(CC)CC,,val
US20050159460A1,CC(C)[C@H](N)C(=O)O.O=C(Cl)CCc1ccccc1>>CC(C)[C@H](NC(=O)CCc1ccccc1)C(=O)O,,CCOCC,,[Na+].[OH-],,val
US20110112110A1,CN1CCNCC1.O=C(O)c1ccc(B(O)O)cc1>>CN1CCN(C(=O)c2ccc(B(O)O)cc2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US04786648,Cl.NO.O=Cc1ccncc1>>Cl.ON=Cc1ccncc1,,CO,,,,val
US20050014791A1,BrBr.COC(=O)c1ccc(CC(=O)O)cc1OC>>COC(=O)c1cc(Br)c(CC(=O)O)cc1OC,,CC(=O)O,,CCCCCC,,val
US03993656,CCOC(=O)c1cc2c(C)c(NC(C)=O)c(C)nc2[nH]c1=O>>CC(=O)Nc1c(C)nc2[nH]c(=O)c(C(=O)O)cc2c1C,,O,,CC(=O)O,[K+].[OH-],val
US20070072865A1,CC(C)(C)OC(=O)NCCN1CC=CCC1>>CNCCN1CC=CCC1,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20070093501A1,NC1CCN(Cc2ccccc2)CC1.O=Cc1c[nH]cn1>>c1ccc(CN2CCC(NCc3c[nH]cn3)CC2)cc1,,CC(=O)O,ClCCCl,[Na+].[OH-],,val
US20130303524A1,C=CCN.O=S(=O)(Cl)CCCl>>C=CCNS(=O)(=O)C=C,,ClCCl,,CCN(CC)CC,,val
US20090156642A1,CCOC(=O)c1cc(O)n(-c2ccccc2C)n1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)c1cc(OS(=O)(=O)C(F)(F)F)n(-c2ccccc2C)n1,,C1CCOC1,,CCN(CC)CC,O,val
US06177462B1,CC(=O)C=Cc1ccc(C)cc1.NO>>CC(C=Cc1ccc(C)cc1)=NO,,CO,,Cl,[Na+].[OH-],val
US20130274460A1,Cc1ccc(C)c(C)c1C.Cc1ccc(S(=O)CBr)cc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1ccc([S+](CBr)c2cc(C)c(C)c(C)c2C)cc1.O=S(=O)([O-])C(F)(F)F,,CCOCC,,,,val
US20050124654A1,NO.O=C1CCc2cc(Br)ccc2C1>>ON=C1CCc2cc(Br)ccc2C1,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20080105851A1,CNc1ccccn1.Cn1c(CCl)nc2ccccc21>>CN(Cc1nc2ccccc2n1C)c1ccccn1,,C1CCOC1,,[H-].[Na+],,val
US06010681,CC(C)(C)OC(=O)CN1CCNCCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1.COC(=O)CBr>>COC(=O)CN1CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1,,CC#N,,Br,,val
US04624954,Cc1c2n(c3ccccc13)CCCC2N(C=O)C(C)C>>Cc1c2n(c3ccccc13)CCCC2N(C)C(C)C,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20130210825A1,C=Cc1c(C)nc2cc(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)nn12>>C=Cc1c(C)nc2cc(-c3ccccc3)c(-c3ccc(C4(N)CCC4)cc3)nn12,,C1COCCO1,Cl,,,val
US20080214641A1,CC(=O)OCC(=O)Cl.CCC[C@H](N)[C@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccccc1>>CCC[C@H](NC(=O)CO)[C@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US04544667,CO.NS(=O)(=O)c1cc2ccc(OCC3CO3)cc2o1>>COCC(O)COc1ccc2cc(S(N)(=O)=O)oc2c1,O=S(=O)(O)O,,,,,val
US20040077669A1,Clc1cc(Cl)ncn1.O[C@H]1CCCC[C@H]1O>>O[C@H]1CCCC[C@H]1Oc1cc(Cl)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20140274954A1,COB(OC)OC.Cc1ccc(C(=O)O)cc1Br>>Cc1ccc(C(=O)O)cc1B(O)O,,C1CCOC1,,[Li]CCCC,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(-c2ccc(O)cc2)c2ncnn12.COC(=O)C(C)(C)Br>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(-c2ccc(OC(C)(C)C(=O)OC)cc2)c2ncnn12,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US05380742,CI.Cc1ccc(S(=O)(=O)N2Cc3cscc3C2)cc1>>Cc1ccc(S(=O)(=O)N2Cc3csc(C)c3C2)cc1,,C1CCOC1,CCCCCC,O,[Li]CCCC,val
US20160194316A1,CC1(C)OB(c2ccc(CN3CCOCC3)cc2)OC1(C)C.CCCN(c1cc(Br)cc(C(=O)OC)c1C)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1>>CCCN(c1cc(-c2ccc(CN3CCOCC3)cc2)cc(C(=O)OC)c1C)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20060160794A1,CN(Cc1ccccc1Cl)C(=O)c1nnn(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1Cl.Sc1ccccc1>>CN(Cc1ccccc1Cl)C(=O)c1nnn(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1Sc1ccccc1,,CN(C)C=O,O,,,val
US20110257151A1,CC1(C)Cc2cc(C(F)(F)F)ccc2NC1c1cccc(N)c1.COC(=O)C(C)(C)Br>>COC(=O)C(C)(C)Nc1cccc(C2Nc3ccc(C(F)(F)F)cc3CC2(C)C)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150320736A1,CC(C)(C#Cc1cc(N)c(F)cc1NCC(O)COCc1ccccc1)COCc1ccccc1>>CC(C)(COCc1ccccc1)c1cc2cc(N)c(F)cc2n1C[C@@H](O)COCc1ccccc1,[Cu]I,CC#N,,,,val
US20020028832A1,CC(C)(C)[Si](Oc1ccc(OCC2CO2)cc1)(c1ccccc1)c1ccccc1.COc1ccc(CCCCNC(=O)N2CCC(Nc3ccc(CCN)cc3)CC2)cc1OC>>COc1ccc(CCCCNC(=O)N2CCC(Nc3ccc(CCNCC(O)COc4ccc(O)cc4)cc3)CC2)cc1OC,,CO,ClC(Cl)Cl,,,val
US20130252936A1,CNCCN(C)C.O=C(O)Cn1nc(-c2ccccc2)c2c(Cl)c(-c3ccccc3)nnc21>>CN(C)CCN(C)C(=O)Cn1nc(-c2ccccc2)c2c(Cl)c(-c3ccccc3)nnc21,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05202407,CCI.Cc1ccc(P(c2ccc(C)cc2)c2ccc(C)cc2)cc1>>CC[P+](c1ccc(C)cc1)(c1ccc(C)cc1)c1ccc(C)cc1.[I-],,Cc1ccccc1,,O=P(O)(O)O,,val
US20120035214A1,CC(=O)c1c([C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(O)c2ccc(F)c(F)c2)noc1-c1c(Cl)cccc1Cl>>CC(O)c1c([C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(O)c2ccc(F)c(F)c2)noc1-c1c(Cl)cccc1Cl,,CO,,[BH4-].[Na+],,val
US05329033,COC(=O)C(C)Cc1ccccc1C>>Cc1ccccc1CC(C)C(=O)O,,CO,,[Na+].[OH-],,val
US20100075948A1,CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.Nc1ccc(-c2nnn[nH]2)cc1>>CC(C)(C)CC1NC(C(=O)Nc2ccc(-c3nnn[nH]3)cc2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020143026A1,CC(=O)CC(N)=O.NC(N)=O.O=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CC1=C(C(N)=O)C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)N1,Cl[Cu]Cl,C1CCOC1,CC(=O)O,CCOCC,FB(F)F,val
US20080167329A1,NCC(F)(F)F.O=C(c1ccc(Br)cc1)c1cc(Cl)ccc1NC(=O)n1ccnc1>>O=C1Nc2ccc(Cl)cc2C(O)(c2ccc(Br)cc2)N1CC(F)(F)F,,C1CCOC1,,,,val
US20100317659A1,CON.Cc1cc(Nc2nc(C(=O)c3ccc(F)cc3)nc3ccccc23)n[nH]1>>CON=C(c1ccc(F)cc1)c1nc(Nc2cc(C)[nH]n2)c2ccccc2n1,,CCO,,Cl,O,val
US06465482B2,CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1cc(N2CCNCC2)c2nccnc2c1.Cn1cc(C2CCC(=O)CC2)c2cc(C#N)ccc21>>COc1cc(N2CCN([C@@H]3CC[C@H](c4cn(C)c5ccc(C#N)cc45)CC3)CC2)c2cccnc2c1,,CC(Cl)Cl,,CC(=O)O,,val
US20150133428A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Fc1ccc(-c2cc3n(n2)CCNC3)cc1>>CC(C)(C)OC(=O)N1CCn2nc(-c3ccc(F)cc3)cc2C1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20140288045A1,CC(C)(C)OC(=O)N1CCNC(C(N)=O)C1.CS(=O)(=O)OC1CN(C(c2ccccc2)c2ccccc2)C1>>CC(C)(C)OC(=O)N1CCN(C2CN(C(c3ccccc3)c3ccccc3)C2)C(C(N)=O)C1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20060270688A1,CCOC(=S)[S-].Nc1cc([N+](=O)[O-])ccc1F>>O=[N+]([O-])c1ccc2sc(S)nc2c1,,CN(C)C=O,O,Cl,,val
US20120114739A1,CC(C)(C)OC(=O)N1CCC(CC(=O)CC#N)CC1.Nc1ccn[nH]1>>CC(C)(C)OC(=O)N1CCC(Cc2cc(N)n3nccc3n2)CC1,,CC(=O)O,,,,val
US20060194837A1,CN.O=Cc1cccc(OCCCO)c1>>CNCc1cccc(OCCCO)c1,,CO,,[BH4-].[Na+],,val
US20080015199A1,COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc2c(c(OC)c1)OCCC2.NNc1ncccc1F>>COc1cc(C(Nc2ccc(-c3noc(C)n3)cc2)c2nn(-c3ncccc3F)c(=O)[nH]2)cc2c1OCCC2,,CN(C)C=O,,CCN(CC)CC,,val
US20130237525A1,BrC(Br)(Br)Br.OCc1cccc(OC(F)F)n1>>FC(F)Oc1cccc(CBr)n1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040138251A1,COc1cc(N)c(Cl)cc1Cl.Cc1cc2c(Cl)c(C#N)cnc2s1>>COc1cc(Nc2c(C#N)cnc3sc(C)cc23)c(Cl)cc1Cl,,C1CCOC1,,[H-].[Na+],,val
US20140051676A1,COC(=O)c1ccc(-c2nc(-c3nc(N)nc(N(C)c4ccccc4)n3)no2)cn1>>CN(c1ccccc1)c1nc(N)nc(-c2noc(-c3ccc(CO)nc3)n2)n1,,C1CCOC1,,[BH4-].[Na+],,val
US20090182002A1,COC(=O)c1cc(Cl)cnc1C.O=Cc1ccc(Br)cc1>>O=C(O)c1cc(Cl)cnc1/C=C/c1ccc(Br)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20080312224A1,CCCCCc1cc(OC)c([C@@H]2CCCC[C@H]2C(=O)OC)c(OC)c1>>CCCCCc1cc(O)c2c(c1)OC(=O)[C@@H]1CCCC[C@@H]21,,ClCCl,,BrB(Br)Br,,val
US20120082702A1,CC(C)(C)OC(=O)N[C@@H]1CCCNC1.NC(=O)c1ccc(Cl)nc1Nc1ccc(C(=O)N2CCOCC2)cc1>>CC(C)(C)OC(=O)N[C@@H]1CCCN(c2ccc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)C1,,CN1CCCC1=O,O,CCN(C(C)C)C(C)C,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n(C2CCC3(CC2)OCCO3)c2ccnn12>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n([C@@H]2CC[C@@H](O)CC2)c2ccnn12,,C1CCOC1,CCOC(C)=O,Cl,[Na+].[OH-],val
US04612309,COc1ccc2occc(=O)c2c1>>COc1ccc2c(c1)C(O)CCO2,[Pd],CCO,,CCN(CC)CC,,val
US20060041146A1,CC(C)(C)OC(=O)N[C@@H](C(=O)O)c1ccc(OCCN2CCOCC2)cc1.CCC(=O)c1csc(NC(=O)[C@H]([C@@H](C)c2ccccc2)N2C(=O)N[C@H](c3ccc(OC)cc3)C2=O)n1>>CCC(=O)c1csc(NC(=O)[C@@H](NC(=O)[C@H](NC(=O)OC(C)(C)C)c2ccc(OCCN3CCOCC3)cc2)[C@@H](C)c2ccccc2)n1,,C1CCOC1,,CCN=C=NCCCN(C)C,Cl,val
US20020025957A1,COC(=O)CC(=O)OC.Cc1cc2cc(N=C=S)ccc2o1.N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O>>COC(=O)C(C(=O)OC)=C(Nc1ccc2oc(C)cc2c1)N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O,Cl[Hg]Cl,CN(C)C=O,,[H-].[Na+],,val
US20060264415A1,O=S(=O)(Cl)c1ccc(I)cc1.[K+].[OH-]>>O=S(=O)([O-])c1ccc(I)cc1.[K+],,O,,,,val
US06573270B1,CS(=O)(=O)c1cnc(Cl)nc1.Cc1ccc(-c2c(OCCO)nn(C)c2NS(=O)(=O)c2ccc(C(C)C)cn2)cc1>>Cc1ccc(-c2c(OCCOc3nccc(S(C)(=O)=O)n3)nn(C)c2NS(=O)(=O)c2ccc(C(C)C)cn2)cc1,,C1CCOC1,CC(=O)N(C)C,[H-].[Na+],,val
US20150133512A1,CCc1nnn(-c2ccc(Br)cc2)c1C(=O)O.C[C@@H](O)c1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCc1nnn(-c2ccc(Br)cc2)c1NC(=O)O[C@H](C)c1ccccc1,,Cc1ccccc1,,CCN(CC)CC,,val
US20100120801A1,ICCCCI.O=C1Cc2c(Cl)ncnc2N1>>O=C1Nc2ncnc(Cl)c2C12CCCC2,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05883106,CC(C)(C)[Si](C)(C)Cl.Oc1cc(F)ccc1F>>CC(C)(C)[Si](C)(C)Oc1cc(F)ccc1F,,CN(C)C=O,,O,[H-].[Na+],val
US20150359215A1,CCCCCCCCCCC(OOC(C)=O)C(=O)O.CCCO>>CCCCCCCCCCC(OC(C)=O)C(=O)OCCC,,ClCCl,,CC(C)N=C=NC(C)C,,val
US20110224208A1,COCCN.O=C(Cl)c1cccs1>>COCCNC(=O)c1cccs1,,ClCCl,,CCN(CC)CC,O,val
US04551460,O=C(O)CCCCCc1cccnc1>>OCCCCCCc1cccnc1,,C1CCOC1,,B,,val
US20110237551A1,COc1cc(/C=C/C(=O)O)ccc1O.NCCc1ccc(O)c(O)c1>>COc1cc(/C=C/C(=O)NCCc2ccc(O)c(O)c2)ccc1O,,CN(C)C=O,ClCCl,CCN(CC)CC,,val
US20110244481A1,CC(C)(C)[Si](C)(C)Oc1ccc(-c2cnc(N)c(-c3ccc([N+](=O)[O-])cc3)n2)cc1.CC(C)(C)[Si](C)(C)Oc1ccc(CC(=O)Cl)cc1>>CC(C)(C)[Si](C)(C)Oc1ccc(CC(=O)Nc2ncc(-c3ccc(O[Si](C)(C)C(C)(C)C)cc3)nc2-c2ccc([N+](=O)[O-])cc2)cc1,CN(C)c1ccncc1,c1ccncc1,,O,,val
US20110178001A1,CC(=O)Oc1ccc(CO)cc1.O=C(Cl)Cl>>CC(=O)Oc1ccc(CC(=O)Cl)cc1,,Cc1ccccc1,,,,val
US20100137286A1,COC(=O)[C@@H]1CC[C@@H](Oc2cccnc2)CC1.NN>>NNC(=O)[C@@H]1CC[C@@H](Oc2cccnc2)CC1,,CCCCO,,O,,val
US03931205,CC(=O)O.N#CCc1ccc2oc3ncccc3c(=O)c2c1>>O=C(O)Cc1ccc2oc3ncccc3c(=O)c2c1,,Cl,,,,val
US20120142928A1,CN(C)c1ccc2c(n1)n(C1CCNCC1)c(=O)n2C.CS(=O)(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2CC2CO2)C1>>CN(C)c1ccc2c(n1)n(C1CCN(C[C@H](O)Cn3nc(-c4ccc(C(F)(F)F)cc4)c4c3CCN(S(C)(=O)=O)C4)CC1)c(=O)n2C,,CC(Cl)Cl,ClCCl,[Na+].[OH-],,val
US04028404,Cc1cccc(C(=O)C2CC2)c1.O=C1CCC(=O)N1Br>>O=C(c1cccc(CBr)c1)C1CC1,,ClC(Cl)(Cl)Cl,,,,val
US20070191457A1,CCOC(=O)c1c(C(F)(F)F)cc(C)nc1CBr.COc1ccc(N)cc1OCCN1CCC(C)CC1.Cl>>COc1ccc(N2Cc3nc(C)cc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1.Cl,,CN(C)C=O,,,,val
US20140018313A1,Nc1ccc2cc(Br)ccc2c1[N+](=O)[O-]>>Nc1ccc2cc(Br)ccc2c1N,[Ni],CCO,,,,val
US20120252780A1,CN(C)c1nc(-c2cccc(F)c2)nc2c1OCCN2.Nc1ccncc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN(C)c1nc(-c2cccc(F)c2)nc2c1OCCN2C(=O)Nc1ccncc1,,ClCCl,,CCN(CC)CC,,val
US05296492,CC1(C)C=C(n2ccc(CCCO[Si](C)(C)C(C)(C)C)cc2=O)c2cc(C#N)ccc2O1>>CC1(C)C=C(n2ccc(CCCO)cc2=O)c2cc(C#N)ccc2O1,,C1COCCO1,CO,Cl,,val
US20140371176A1,N#CCCCN1CCC(CN(C(=O)C(F)(F)F)C2CC2c2ccccc2)CC1.[N-]=[N+]=[N-]>>O=C(N(CC1CCN(CCCc2nnn[nH]2)CC1)C1CC1c1ccccc1)C(F)(F)F,,CN(C)C=O,,[Cl-].[NH4+],,val
US06451839B1,CC(C)(C)OC(=O)CBr.CCc1cc2c(O)cccc2n1Cc1ccccc1-c1ccccc1>>CCc1cc2c(OCC(=O)OC(C)(C)C)cccc2n1Cc1ccccc1-c1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20090186870A1,COC(=O)c1cc([N+](=O)[O-])c(OC(C)C)cc1Cl>>COC(=O)c1cc(N)c(OC(C)C)cc1Cl,[Pt],C1CCOC1,CO,,,val
US04228183,CSCC[C@H](NC(C)=O)C(=O)O.NCCc1ccc(O)c(O)c1>>CSCC[C@H](NC(C)=O)C(=O)NCCc1ccc(O)c(O)c1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20140315917A1,Cn1cc(-c2cc(Oc3ccc(N)c(F)c3Cl)ccn2)cn1.O=C(Cl)N1CCN(C2CCOCC2)C1=O>>Cn1cc(-c2cc(Oc3ccc(NC(=O)N4CCN(C5CCOCC5)C4=O)c(F)c3Cl)ccn2)cn1,,ClCCl,,O,,val
US20160244414A1,COC(=O)c1nn(-c2ccccc2)c(=O)cc1Sc1ccccc1.NN>>NNC(=O)c1nn(-c2ccccc2)c(=O)cc1Sc1ccccc1,,CCO,,O,,val
US20130244929A1,COC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)CCNC(=O)OCc1ccccc1>>COC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)CCN,[Pd],CCO,,[H][H],,val
US20100009957A1,N[C@H]1CCCCN(Cc2ccccc2)C1.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O>>O=C(N[C@H]1CCCCN(Cc2ccccc2)C1)ON1C(=O)CCC1=O,,CC#N,,CCN(C(C)C)C(C)C,,val
US20160185778A1,C[C@H]1Cc2[nH]nc(C3CCCC3)c2CN1C(=O)OC(C)(C)C>>C[C@H]1Cc2[nH]nc(C3CCCC3)c2CN1,,C1COCCO1,,Cl,,val
US20040034049A1,CC(=O)Oc1c(C)c(C)c2oc(C)c(-c3ccccc3)c2c1C>>Cc1oc2c(C)c(C)c(O)c(C)c2c1-c1ccccc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20040029888A1,CN(C)C(C)(C)CO.Clc1ncccc1OCCOC1CCCCO1>>CN(C)C(C)(C)COc1ncccc1OCCO,,Cc1ccccc1,,CC(C)(C)O,CC(C)(C)[O-].[K+],val
US20060089349A1,CC1(C)CC2CC(C)(CN2C(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)C1.COCCBr>>COCCNc1ccc(C(=O)N2CC3(C)CC2CC(C)(C)C3)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20110160243A1,CCOC(=O)CP(=O)(OCC)OCC.O=C1CCCn2c1cc1cc(OCc3ccccc3)ccc12>>CCOC(=O)C=C1CCCn2c1cc1cc(OCc3ccccc3)ccc12,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20160221990A1,C=Cc1ccc(N2CCN(C(C)=O)CC2)cc1.Fc1cc(Br)cc(-c2ccncc2)c1>>CC(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(-c4ccncc4)c3)cc2)CC1,,C1CCOC1,,CCN(CC)CC,Cc1ccccc1P(c1ccccc1C)c1ccccc1C,val
US20060183749A1,CS(=O)(=O)Cl.O=c1cc(CO)occ1OCCCCCOc1ncnc2ccccc12>>CS(=O)(=O)OCc1cc(=O)c(OCCCCCOc2ncnc3ccccc23)co1,,ClCCl,ClCCl,CCN(CC)CC,,val
US20120289474A1,Cc1ncoc1Cn1c(=O)n(C2CCN(C(=O)OC(C)(C)C)CC2)c(=O)c2sc(-c3ccccc3)cc21.Cl>>Cc1ncoc1Cn1c(=O)n(C2CCNCC2)c(=O)c2sc(-c3ccccc3)cc21.Cl,,C1COCCO1,,,,val
US20070032501A1,BrBr.Nc1ccc(-c2ccc(F)cc2)cn1>>Nc1ncc(-c2ccc(F)cc2)cc1Br,,CC(=O)O,ClCCl,CC(=O)[O-].[Na+],,val
US20090036492A1,CCCCOc1ccc(C=O)c2ccccc12.COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C>>CCCCOc1ccc(CNC(=O)c2c(OC)cc(O)c3c2OC2=CC(O)=C(C(C)=O)C(=O)[C@]23C)c2ccccc12,,CC#N,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20140275172A1,C#CC.O=Cc1cc(I)cc(I)c1O>>Cc1cc2cc(I)cc(C=O)c2o1,,CCOC(C)=O,c1ccncc1,,,val
US20040009993A1,CCOC(=O)c1ccc(N)cc1.Cc1nc(S(C)(=O)=O)nc2c1ccc(=O)n2-c1ccc(C(=O)OC(C)(C)C)cc1>>CCOC(=O)c1ccc(Nc2nc(C)c3ccc(=O)n(-c4ccc(C(=O)OC(C)(C)C)cc4)c3n2)cc1,,C1COCCO1,,,,val
US05310722,C1CCNNC1.COC(=O)COC(=S)c1cc(N=C=S)c(F)cc1Cl>>COC(=O)COC(=S)c1cc(NC(=S)N2CCCCN2)c(F)cc1Cl,,Cc1ccccc1,,,,val
US20050026916A1,Fc1cccc(CCl)c1.S=C1N[C@@H](c2ccccc2)[C@@H](c2ccccc2)N1>>Cl.Fc1cccc(CSC2=N[C@@H](c3ccccc3)[C@@H](c3ccccc3)N2)c1,,CCO,,,,val
US20110136780A1,C1CCNC1.CC[C@H](NC(=O)OC(C)(C)C)C(=O)O>>CC[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCCC1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06451854B1,Br.CC(C)C[C@@H](N)C(=O)O>>CC(C)CC(Br)C(=O)O,,CCOCC,O,O=N[O-].[Na+],,val
US20060205942A1,CC(C)(C)N=C=O.CN(C)C=O.NCc1cccc(-c2cc(-c3nnn[nH]3)ccc2O)c1>>CC(C)(C)NC(=O)NCc1cccc(-c2cc(-c3nnn[nH]3)cc(C=O)c2O)c1,,CN(C)C=O,O,CCN(CC)CC,CCOC(C)=O,val
US20100004222A1,CC(O)c1cnc2cc(NC(=O)OCc3ccccc3)ccc2c1>>CC(O)c1cnc2cc(N)ccc2c1,[Pd],CO,,,,val
US20150329538A1,Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1F.N>>Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N,,CS(C)=O,,O,,val
US06075043,Cc1cc(N)n(-c2c(Cl)cc(Cl)cc2Cl)n1.O=C1CCC(=O)N1I>>Cc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(N)c1I,,CC#N,,,,val
US04012223,CNCC=O.O=C=Nc1nnc(C2CCCC2)s1>>CN(CC=O)C(=O)Nc1nnc(C2CCCC2)s1,,c1ccccc1,,,,val
US20090221586A1,C=CCBr.CCOc1ccccc1C(=O)CCc1coc(-c2ccc(OC)c(O)c2)n1>>C=CCOc1cc(-c2nc(CCC(=O)c3ccccc3OCC)co2)ccc1OC,,CCO,,C1CCC2=NCCCN2CC1,,val
US05281571,COc1cc(-c2nn(C)c(C(F)(F)F)c2Br)c(F)cc1[N+](=O)[O-]>>COc1cc(-c2nn(C)c(C(F)(F)F)c2Br)c(F)cc1N,[Fe],CC(=O)O,,,,val
US20010053788A1,CNC.CSC(=NS(=O)(=O)c1ccc(Cl)cc1)N1CC(c2ccccc2)C(c2ccc(Cl)cc2)=N1>>CN(C)C(=NS(=O)(=O)c1ccc(Cl)cc1)N1CC(c2ccccc2)C(c2ccc(Cl)cc2)=N1,,CO,,ClCCl,,val
US20140121198A1,CCCC#N.C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CCNC1>>C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CCN(CCCC#N)C1,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20090117125A1,COC(=O)c1c(C(=O)OC)c(-c2ccc(OC)cc2)n2c1Cc1ccccc1C2>>COc1ccc(-c2c(CO)c(CO)c3n2Cc2ccccc2C3)cc1,,CCOCC,ClCCl,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110269780A1,CCOC(=O)C[C@@H](Nc1nc(C#N)ccc1[N+](=O)[O-])c1ccccc1>>CCOC(=O)C[C@@H](Nc1nc(C#N)ccc1N)c1ccccc1,[Pd],CCO,,,,val
US20100256092A1,CC(C)CCC(=O)Cl.NCC1OB(O)c2ccccc21>>CC(C)CCC(=O)NCC1OB(O)c2ccccc21,,ClCCl,,CCN(CC)CC,,val
US20080221096A1,CN(Cc1ccccc1)c1nc2oc3c(Cl)ncnc3c2c2c1COC(C)(C)C2.NCCN1CCOCC1>>CN(Cc1ccccc1)c1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2c1COC(C)(C)C2,,CCO,,,,val
US20020198197A1,CC(C)(C)OC(=O)Nc1cc(Cl)c(C(F)(F)F)cc1NC(=O)CC(=O)c1cccc(-n2cncn2)c1>>O=C1CC(c2cccc(-n3cncn3)c2)=Nc2cc(Cl)c(C(F)(F)F)cc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150166564A1,Cc1nn(-c2ccccc2)c(NC(=O)Oc2ccccc2)c1C.N[C@@H]1CN(CCO)C[C@H]1c1ccc(F)c(F)c1>>Cc1nn(-c2ccccc2)c(NC(=O)N[C@@H]2CN(CCO)C[C@H]2c2ccc(F)c(F)c2)c1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20160168101A1,CCCCI.Cc1c(-c2ccnn2-c2ccc(C#N)cc2)[nH]c(=O)n1-c1cccc(C(F)(F)F)c1>>CCCCn1c(-c2ccnn2-c2ccc(C#N)cc2)c(C)n(-c2cccc(C(F)(F)F)c2)c1=O,,O,,C1CCOC1,CC(C)(C)[O-].[K+],val
US20160152613A1,BrBr.COC(=O)C1=C(C)N(CC(=O)OC(C)(C)C)C(=O)CC1c1cc(Cl)ccc1Cl>>COC(=O)C1=C(CBr)N(CC(=O)OC(C)(C)C)C(=O)CC1c1cc(Cl)ccc1Cl,,ClCCl,,,,val
US20080255172A1,COc1cccc(N)c1.CSc1ncc(C#N)c(O)n1>>COc1cccc(Nc2ncc(C#N)c(O)n2)c1,,CCCCCO,,,,val
US20040019052A1,NC(=O)c1cc(-c2cccc(F)c2F)nnc1Cl>>N#Cc1cc(-c2cccc(F)c2F)nnc1Cl,,O=P(Cl)(Cl)Cl,,,,val
US20110190309A1,COC(=O)C1(c2ccccc2)CCCCCC1>>O=C(O)C1(c2ccccc2)CCCCCC1,,CO,O,[Na+].[OH-],,val
US20050026916A1,CC(C)(C)[Si](C)(C)Cl.COC(=O)[C@@H](O)c1ccccc1>>COC(=O)C(O[Si](C)(C)C(C)(C)C)c1ccccc1,CN(C)c1ccncc1,CCOCC,ClCCl,c1c[nH]cn1,,val
US20160083363A1,CCOC(=O)c1cc2cc(C(F)(F)F)ccc2[nH]1.O=C1CCC(=O)N1Br>>CCOC(=O)c1[nH]c2ccc(C(F)(F)F)cc2c1Br,,C1CCOC1,,,,val
US20150329529A1,CCOC(=O)c1noc(C2=CCC(C(C)C)CC2)c1C>>Cc1c(C(=O)O)noc1C1=CCC(C(C)C)CC1,,C1CCOC1,,CO,[Na+].[OH-],val
US04837217,CC(C)(C)n1ncc(O)c(Cl)c1=O.CCOCC(C)Oc1ccc(CBr)cc1>>CCOCC(C)Oc1ccc(COc2cnn(C(C)(C)C)c(=O)c2Cl)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06410790B1,CN(C)C(c1ccc(Cl)cc1)C1CCCCC1=O.Cl.Cl[Mg]Cc1ccccc1>>CN(C)C(c1ccc(Cl)cc1)C1CCCCC1(O)Cc1ccccc1.Cl,,C1CCOC1,,O,,val
US20080045493A1,COC(=O)N1CCC(c2cccc(NS(=O)(=O)c3ccc(OC(F)(F)F)cc3)c2)C1>>O=S(=O)(Nc1cccc(C2CCNC2)c1)c1ccc(OC(F)(F)F)cc1,,CCO,,Cl,,val
US20160130263A1,O=Cc1ccc(COc2ccc(Br)cc2)cc1>>OCc1ccc(COc2ccc(Br)cc2)cc1,,CCO,,[BH4-].[Na+],,val
US20090156806A1,COC(=O)CNc1ccc(N2CCOCC2)c(F)c1.COC(C=O)OC>>COC(CNc1ccc(N2CCOCC2)c(F)c1)OC,[Pd],CCO,,,,val
US20050014749A1,N#Cc1ccc2c(c1)CCCC2N1C(=O)c2ccccc2C1=O.O=CO>>O=Cc1ccc2c(c1)CCC[C@H]2N1C(=O)c2ccccc2C1=O,[Ni],O=CO,,O,,val
US04803280,COC(=O)NN.O=C(O)C(S)C(=S)Cc1ccccc1>>COC(=O)NNC(=S)Cc1ccccc1,,O,,[Na+].[OH-],,val
US20130225567A1,Cc1ncnc(C)c1-c1ccc(NC(=O)C(C)N(C)C(=O)OC(C)(C)C)nc1C#Cc1ccc2ccccc2c1>>CNC(C)C(=O)Nc1ccc(-c2c(C)ncnc2C)c(C#Cc2ccc3ccccc3c2)n1,,Cc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,val
US20120035408A1,Nc1ncc(Br)nc1Br.OCc1ccccc1>>Nc1ncc(Br)nc1OCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20130203727A1,C=CC(O)c1c(C)c(Br)c2ccccc2c1-c1ccc(Cl)cc1.CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F>>C=CC(O[Si](C)(C)C(C)(C)C)c1c(C)c(Br)c2ccccc2c1-c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20150175599A1,CO.COc1ccc2[nH]c(C)cc2c1.O=C(Cl)C(=O)Cl>>COC(=O)C(=O)c1c(C)[nH]c2ccc(OC)cc12,,ClCCl,,,,val
US20080221166A1,CNC(=O)[C@H](N)c1ccccc1.COc1ccc(C#N)cc1OC.Cl[Mg]CCc1ccccc1>>CNC(=O)[C@H](N[C@H](CCc1ccccc1)c1ccc(OC)c(OC)c1)c1ccccc1,,C1CCOC1,CO,[BH4-].[Na+],[Cl-].[NH4+],val
US04529548,CC(=O)O[C@H]1C[C@@]2(C)[C@@H](CC[C@@H]2O)[C@@H]2CCC3=CC(=O)C=C[C@]3(C)[C@@]12F.CS(=O)(=O)Cl>>CC(=O)O[C@H]1C[C@@]2(C)[C@@H](CC[C@@H]2OS(C)(=O)=O)[C@@H]2CCC3=CC(=O)C=C[C@]3(C)[C@@]12F,,c1ccncc1,,,,val
US20070049620A1,CCOC(=O)c1ccc(CCN2CC=C(c3c[nH]c(-c4ccc(F)cc4)c3-c3ccncc3)CC2)cc1>>O=C(O)c1ccc(CCN2CC=C(c3c[nH]c(-c4ccc(F)cc4)c3-c3ccncc3)CC2)cc1,,CCO,,Cl,[Li+].[OH-],val
US20060205942A1,COc1c(C=O)cc(S(=O)(=O)NC(C)=O)cc1-c1cccc(S(=O)(=O)NC(C)(C)C)c1>>CC(=O)NS(=O)(=O)c1cc(C=O)c(O)c(-c2cccc(S(N)(=O)=O)c2)c1,,ClCCl,,,,val
US20130267510A1,COCBr.COc1cccc(O)c1>>COCOc1cccc(OC)c1,,C1CCOC1,,O,[H-].[Na+],val
US20090197866A1,CN1CCN(c2ccc3nc(-c4nn(C5CCCCO5)cc4NC(=O)N4CCCCC4)[nH]c3c2)CC1>>CN1CCN(c2ccc3nc(-c4n[nH]cc4NC(=O)N4CCCCC4)[nH]c3c2)CC1,,ClCCl,,O,O=C(O)C(F)(F)F,val
US20160024056A1,C[C@H]1C[C@H](Cn2ccc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CN1.O=S(=O)(Cl)c1ccccc1>>C[C@H]1C[C@H](Cn2ccc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CN1S(=O)(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20040110811A1,CC1(C)NC(=O)NC1=O.O=S(=O)(Cl)c1cccc2ccccc12>>CC1(C)NC(=O)N(S(=O)(=O)c2cccc3ccccc23)C1=O,,C1CCOC1,,[H-].[Na+],,val
US20040087552A1,CC(=O)CC(=O)C1CCN(C(=O)OC(C)(C)C)CC1.CCCCCCCCCCCCc1ccc(S(=O)(=O)N=[N+]=[N-])cc1>>CC(=O)C(=[N+]=[N-])C(=O)C1CCN(C(=O)OC(C)(C)C)CC1,,CC#N,,CCN(CC)CC,CCOCC,val
US05324726,COC(=O)Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1>>CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)O)c2)N=C(c2ccccc2)c2ccccc21,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20050014812A1,CC(=O)Nc1c(C)cc(OC(C)=O)cc1[N+](=O)[O-]>>CC(=O)Nc1c(C)cc(O)cc1[N+](=O)[O-],,CCO,,O=S(=O)(O)O,[Na+].[OH-],val
US20100173910A1,C1CCNCC1.COc1c(NCCNc2cc(N3CCCC3)nc(N3CCCC3)n2)c(=O)c1=O>>O=c1c(NCCNc2cc(N3CCCC3)nc(N3CCCC3)n2)c(N2CCCCC2)c1=O,,CCO,,,,val
US20030045728A1,CCOC(=O)CC(c1ccccc1)c1c[nH]c2cc(OCCCO)ccc12.O=C(Nc1ccccn1)OCC(Cl)(Cl)Cl>>CCOC(=O)CC(c1ccccc1)c1c[nH]c2cc(OCCCN(C(=O)OCC(Cl)(Cl)Cl)c3ccccn3)ccc12,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130012499A1,COC(=O)c1c(CBr)c(-c2cccc(C(F)(F)F)c2)nc2ccc(S(C)(=O)=O)cc12.FC1(F)CCN(C2CCNCC2)C1>>COC(=O)c1c(CN2CCC(N3CCC(F)(F)C3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccc(S(C)(=O)=O)cc12,,CC#N,,,,val
US20090270351A1,CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(CN)cc1.O=C(Cl)OCCl>>CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(CNC(=O)OCCl)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110257151A1,CC1(C)Cc2cc(C(=O)O)ccc2NC1c1cc(C#N)cc(N2CCOCC2)c1.CS(N)(=O)=O>>CC1(C)Cc2cc(C(=O)NS(C)(=O)=O)ccc2NC1c1cc(C#N)cc(N2CCOCC2)c1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20160075681A1,Cc1cn(-c2cccnc2)nc1Cl.O=[Mn](=O)(=O)[O-]>>O=C(O)c1cn(-c2cccnc2)nc1Cl,,CC(C)(C)O,,O,,val
US20150152108A1,NCCc1ccccc1.O=C(Oc1ccccc1)N1c2nc(-c3cccc(C(F)(F)F)c3)ccc2N2CC[C@H]1C2>>O=C(NCCc1ccccc1)N1c2nc(-c3cccc(C(F)(F)F)c3)ccc2N2CC[C@H]1C2,CN(C)c1ccncc1,CC#N,,,,val
US20090036492A1,COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.Cc1ccc(C=O)cc1>>COc1cc(O)c2c(c1C(=O)NCc1ccc(C)cc1)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C,,Cc1ccccc1,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US03992535,COC(=O)C1=C(O)c2ccc3ccccc3c2S(=O)(=O)N1C.Nc1ccc(F)cc1>>CN1C(C(=O)Nc2ccc(F)cc2)=C(O)c2ccc3ccccc3c2S1(=O)=O,,Cc1ccccc1C,,,,val
US20050245518A1,COC(=O)c1ccc(CN)cc1.Clc1ccc(N2CCOCC2)nn1>>COC(=O)c1ccc(CNc2ccc(N3CCOCC3)nn2)cc1,,CC(C)O,,Cl,[Cl-].[NH4+],val
US04788210,CI.Fc1ccccc1-c1n[nH]c(-c2ccccc2C(F)(F)F)n1>>Cn1nc(-c2ccccc2C(F)(F)F)nc1-c1ccccc1F,,CN(C)C=O,,[H-].[Na+],,val
US20120214803A1,CN(C)c1ccncc1.Cc1cccc([N+](=O)[O-])c1S(=O)(=O)Cl.c1ccncc1>>Cc1cccc([N+](=O)[O-])c1S(=O)(=O)Nc1cccc2cccnc12,CN(C)c1ccncc1,ClCCl,,,,val
US05266570,COC(=O)COCC(F)(F)F>>O=C(O)COCC(F)(F)F,,CCOCC,CO,O=S(=O)(O)O,[Na+].[OH-],val
US20160024079A1,COc1cc(C)c2c(ccn2C(=O)OC(C)(C)C)c1C(NS(=O)C(C)(C)C)(c1nc2cc(C#N)cnc2n1COCC[Si](C)(C)C)C(F)(F)F>>COc1cc(C)c2[nH]ccc2c1C(N)(c1nc2cc(C#N)cnc2[nH]1)C(F)(F)F,,CO,,Cl,N,val
US20120295934A1,C=C1CC2C(=O)N(c3ccc(OC(F)(F)F)cc3)C(O)C2C1>>C=C1CC2CN(c3ccc(OC(F)(F)F)cc3)C(=O)C2C1,,O=C(O)C(F)(F)F,,O,[BH3-]C#N.[Na+],val
US04778796,CO.O=[N+]([O-])c1ccc(Cl)nc1>>COc1ccc([N+](=O)[O-])cn1,,C1CCOC1,,O,[H-].[Na+],val
US20140179720A1,CC(C)(C)OC(=O)Nc1cccc(Nc2nc(Cl)ncc2F)c1.COCCOc1ccc(N)cc1>>COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)OC(C)(C)C)c3)n2)cc1,CC(=O)O,CCC(C)(C)O,,,,val
US20110098324A1,CC(C)CN.CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(C2CCC2)c1=O>>CC(C)CNC(=O)c1c(O)c(C(=O)NCC(=O)O)c(=O)n(C2CCC2)c1O,,ClC(Cl)Cl,,Cl,,val
US20120208797A1,Cn1c(Cl)nc(-c2ccncc2F)cc1=O.OC[C@H]1CCN(c2ccsc2)C1>>Cn1c(OC[C@H]2CCN(c3ccsc3)C2)nc(-c2ccncc2F)cc1=O,,CN(C)C=O,,[H-].[Na+],,val
US04193800,CNC.O=[N+]([O-])c1ccc(CCl)cc1>>CN(C)Cc1ccc([N+](=O)[O-])cc1,,CCO,,,,val
US20080200697A1,c1ccc(C23OC2CCc2cc4c(cc23)OCO4)cc1>>O=C1CCc2cc3c(cc2C1c1ccccc1)OCO3,,Cc1ccccc1,,O=S(=O)([O-])[O-].[Mg+2],,val
US20120101124A1,CCOC(CBr)OCC.COc1ccc(Br)cc1O>>CCOC(COc1cc(Br)ccc1OC)OCC,,CN(C)C=O,,[H][H],[H-].[Na+],val
US20120094971A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)C/C=C/CCO[Si](C)(C)C(C)(C)C>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)C/C=C/CCO,,C1CCOC1,CCOCC,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05250527,Cc1cc(Br)cnc1C.O=C(OO)c1cccc(Cl)c1>>Cc1cc(Br)c[n+]([O-])c1C,,ClCCl,,,,val
US20150210688A1,CNC.Cc1ccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)cc1-c1[nH]c(CCCl)nc1C>>Cc1ccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)cc1-c1[nH]c(CCN(C)C)nc1C,,CCO,,,,val
US03979444,CC1(c2ccccc2)CCC(=O)CC1>>CC1(c2ccccc2)CCC(O)CC1,,CCO,,[BH4-].[Na+],,val
US20150166549A1,O=CC1=C(c2ccccc2)c2ccccc2CO1>>OCC1=C(c2ccccc2)c2ccccc2CO1,,CO,,[BH4-].[Na+],,val
US20090054467A1,C#CCc1ccc(N)cc1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C#CCc1ccc(NC(=O)OC(C)(C)C)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20150057298A1,COC(=O)c1ccc(CN)cc1.c1ccc(C[C@H]2CO2)cc1>>COC(=O)c1ccc(CNC[C@@H](O)Cc2ccccc2)cc1,,CO,,CCN(C(C)C)C(C)C,Cl,val
US20120136000A1,CC1(C)CC1(O)c1cnccn1>>CC1(C)CC1(O)C1CNCCN1,O=[Pt],CO,,,,val
US20050026836A1,C=CC1CCCCC1.Nc1ncc(Cl)cc1Br>>Nc1ncc(Cl)cc1/C=C/C1CCCCC1,,CCCCCC,,,,val
US20100056597A1,COC(=O)C(=O)C(F)(F)F.Cc1cc(=O)n(-c2ccc(Cl)cc2)[nH]1>>COC(=O)C(O)(c1c(C)[nH]n(-c2ccc(Cl)cc2)c1=O)C(F)(F)F,,ClC(Cl)Cl,,,,val
US05750531,CCCc1cc(N2CCc3ccccc3C2C)nc(Cl)n1.Nc1ccc(F)cc1>>CCCc1cc(N2CCc3ccccc3C2C)nc(Nc2ccc(F)cc2)n1.Cl,,CN(C)C=O,,,,val
US20130336965A1,C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](NC(=O)OC(C)(C)C)[C@H]1S(C)(=O)=O>>C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040063944A1,Cn1c(=O)cc(CCc2cccc(Cl)c2)c2cc(C(Cl)(c3ccc(Cl)cc3)c3cccnc3)ccc21.N>>Cn1c(=O)cc(CCc2cccc(Cl)c2)c2cc(C(N)(c3ccc(Cl)cc3)c3cccnc3)ccc21,,C1CCOC1,,CC(C)O,,val
US20130287731A1,Brc1ccc(-c2c[nH]c([C@@H]3C=C(C4CC4)CN3)n2)cc1.COC(=O)N[C@H](C(=O)O)C(C)C>>COC(=O)N[C@H](C(=O)N1CC(C2CC2)=C[C@H]1c1nc(-c2ccc(Br)cc2)c[nH]1)C(C)C,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150051199A1,CC(=O)OC(=O)[C@@H](O)c1ccccc1.CC[C@@H](NC(C)CC(N)=O)c1ccc(Cl)c(C(=O)c2ccc(N)nc2)c1F>>CC(=O)OC(=O)[C@@H](O)c1ccccc1.CC[C@@H](N[C@@H](C)CC(N)=O)c1ccc(Cl)c(C(=O)c2ccc(N)nc2)c1F,,CCO,,,,val
US20100056490A1,CC(C)(C)OC(=O)N[C@H]1CS(=O)(=O)C[C@@H](Cc2cc(F)c([N+](=O)[O-])c(OC(C(F)(F)F)C(F)(F)F)c2)[C@@H]1O.Cl>>Cl.N[C@H]1CS(=O)(=O)C[C@@H](Cc2cc(F)c([N+](=O)[O-])c(OC(C(F)(F)F)C(F)(F)F)c2)[C@@H]1O,,C1CCOC1,C1COCCO1,,,val
US20030203909A1,COc1ccc2c(N)c(C(=O)Nc3ccc(Cl)cc3Cl)oc2c1.O=C=NS(=O)(=O)Cl>>COc1ccc2c(NC(N)=O)c(C(=O)Nc3ccc(Cl)cc3Cl)oc2c1,,ClCCl,,O,,val
US04786654,CC1(C)C(CO)C1(C)C.Fc1ccc(CBr)cc1Br>>CC1(C)C(COCc2ccc(F)c(Br)c2)C1(C)C,,CN(C)C=O,Cc1ccccc1,[H-].[Na+],[Cl-].[NH4+],val
US20050004200A1,CCOC(=O)CC(Cc1cc(O)n(CC(F)(F)F)n1)c1ccc2c(c1)OCO2.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCOC(=O)CC(Cc1cc(S)n(CC(F)(F)F)n1)c1ccc2c(c1)OCO2,,c1ccccc1,,,,val
US08129361B2,BrCCCCc1ccccc1.CC(C)(C)OC(=O)NC(CO)(CO)CCc1ccc(O)c(C(F)(F)F)c1>>CC(C)(C)OC(=O)NC(CO)(CO)CCc1ccc(OCCCCc2ccccc2)c(C(F)(F)F)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130336920A1,CC(C)(C)OC(=O)N(Cc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(N3CCCCC3)ccc2[N+](=O)[O-])c1>>CC(C)(C)OC(=O)N(Cc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(N3CCCCC3)ccc2N)c1,[Zn],ClCCl,,CC(=O)O,,val
US20150025237A1,CC(=O)OC[C@@H]1C[C@@]1(CO)c1cccc(F)c1.Cc1ccc(S(=O)(=O)OS(=O)(=O)c2ccc(C)cc2)cc1>>CC(=O)OC[C@@H]1C[C@@]1(COS(=O)(=O)c1ccc(C)cc1)c1cccc(F)c1,,CCCCCCC,CCOC(C)=O,c1ccncc1,,val
US20080227770A1,CCOC(=O)c1cnn(-c2ccccc2C(=O)O)c1C[C@H]1O[C@H](c2cccc(OC)c2OC)c2cc(Cl)ccc2N(CC(C)(C)COC(C)=O)C1=O>>COc1cccc([C@H]2O[C@H](Cc3c(C(=O)O)cnn3-c3ccccc3C(=O)O)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,CCO,,Cl,[Na+].[OH-],val
US20120214785A1,CSc1nccc(C#Cc2ccc(CC(C)NC(C)=O)cc2)n1.O=C(OO)c1cccc(Cl)c1>>CC(=O)NC(C)Cc1ccc(C#Cc2ccnc(S(C)=O)n2)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20120142735A1,COCCBr.Fc1ccc(C(F)(F)F)c2cc[nH]c12>>COCCn1ccc2c(C(F)(F)F)ccc(F)c21,,CS(C)=O,,[K+].[OH-],,val
US20060173010A1,CI.Sc1ncnc(-c2ccccn2)n1>>CSc1ncnc(-c2ccccn2)n1,,CC(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20070219206A1,CCOC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCCc3nc4ccccc4s3)ccc2n1Cc1ccc(-c2ccc(OC)nc2)cc1>>CCOC(=O)C(C)(C)Cc1cc2cc(OCCc3nc4ccccc4s3)ccc2n1Cc1ccc(-c2ccc(OC)nc2)cc1,,ClCCl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20130252962A1,COc1ccc(CN2C(=O)C(c3cc(C#N)c(O)cc3O)c3ccccc32)cc1.ClCI>>COc1ccc(CN2C(=O)C3(COc4cc(O)c(C#N)cc43)c3ccccc32)cc1,,C1CCOC1,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US05288719,CC(C)(C)OC(=O)NCCC(=O)O.NCC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21>>CC(C)(C)OC(=O)NCCC(=O)NCC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US04956359,C#CCN.O=C(Cl)N1CC(Oc2ccc(Cl)c(Cl)c2)C1>>C#CCNC(=O)N1CC(Oc2ccc(Cl)c(Cl)c2)C1,,C1CCOC1,O,O=C([O-])[O-].[K+].[K+],,val
US20160137636A1,COc1cc(-c2cccc(F)c2)c(Cl)cc1B(O)O.Cn1cc(Br)c2ccc(S(=O)(=O)Nc3ccon3)cc21>>COc1cc(-c2cccc(F)c2)c(Cl)cc1-c1cn(C)c2cc(S(=O)(=O)Nc3ccon3)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20120149699A1,Cc1c(NC(=O)OC(C)(C)C)nc2ccc(Cl)cn12.Cl>>Cc1c(N)nc2ccc(Cl)cn12.Cl,,C1COCCO1,Cl,CO,,val
US20100286118A1,COc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)C3(NC(=O)OC(C)(C)C)CCOCC3)cc2)cc1>>COc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)C3(N)CCOCC3)cc2)cc1,,O=CO,,,,val
US04772704,CSc1ncc([N+](=O)[O-])c(O)n1.NCCCOc1cccc(CN2CCCCC2)c1>>O=c1[nH]c(NCCCOc2cccc(CN3CCCCC3)c2)ncc1[N+](=O)[O-],,CCO,,,,val
US20080214615A1,CNCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C=Nc1ccccc1>>CN(Cc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)Nc1ccccc1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20100298384A1,CC(C)(C)[SiH2]OC(C)(C)c1cnn(-c2c(F)cc(N3C[C@H](CO)OC3=O)cc2F)c1.CS(=O)(=O)Cl>>CC(C)(C)[SiH2]OC(C)(C)c1cnn(-c2ccc(N3C[C@H](COS(C)(=O)=O)OC3=O)cc2F)c1,,ClCCl,,CCN(CC)CC,,val
US20040077726A1,COC(=O)C=Cc1cccc(S(=O)(=O)Cl)c1.Nc1cccc2ccccc12>>COC(=O)C=Cc1cccc(S(=O)(=O)Nc2cccc3ccccc23)c1,,C1COCCO1,O,O=C([O-])O.[Na+],,val
US20100286211A1,ON=Cc1cn(-c2ccc(Br)cn2)cn1>>N#Cc1cn(-c2ccc(Br)cn2)cn1,,CC(=O)OC(C)=O,,,,val
US20120225854A1,CC1(C)OB(c2ccc(S(=O)(=O)c3ccc(N)nc3)cc2)OC1(C)C.OC(c1ccc(Cl)nc1)(C(F)(F)F)C(F)(F)F>>Nc1ccc(S(=O)(=O)c2ccc(-c3ccc(C(O)(C(F)(F)F)C(F)(F)F)cn3)cc2)cn1,,O,,COCCOC,O=C([O-])[O-].[Cs+].[Cs+],val
US20050154040A1,Cc1cccc(C(=O)OC(C)(C)C)c1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)c1cccc(CBr)c1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20060178399A1,CCON.Cl.O=C(O)c1ccc(Oc2ccc(CN3CCC(C(=O)c4ccc(Br)cc4)CC3)cc2)cc1>>CCO/N=C(\c1ccc(Br)cc1)C1CCN(Cc2ccc(Oc3ccc(C(=O)O)cc3)cc2)CC1.Cl,,CCO,,Cl,c1ccncc1,val
US20040097594A1,CCC(CC)ONC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12.O=S(=O)(Cl)c1ccc2c(c1)OCO2>>CCC(CC)ON(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12)S(=O)(=O)c1ccc2c(c1)OCO2,CN(C)c1ccccn1,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20060276464A1,O=C1CCC(=O)O1.O=S(=O)(NC1CCNCC1)c1cc(S(=O)(=O)c2ccccc2)ccc1C(F)(F)F>>O=C(O)CCC(=O)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1,,CCO,,,,val
US05506194,CON.Cc1c(Br)ccc2c1C(=O)CCS2>>CON=C1CCSc2ccc(Br)c(C)c21,,c1ccncc1,,CCO,Cl,val
US06943184B2,CN(C)C(=O)C1CC1OC1CCCCO1>>CN(C)C[C@@H]1C[C@H]1OC1CCCCO1,,CCOCC,,,,val
US20050148659A1,CC1(C)C=Cc2cc(CC(=O)NCc3ccccc3)ccc2O1.O=C(OO)c1cccc(Cl)c1>>CC1(C)Oc2ccc(CC(=O)NCc3ccccc3)cc2C2OC21,,ClCCl,,O=C([O-])O.[Na+],,val
US20150126490A1,CC(C)(C)OC(=O)N[C@H](CN=[N+]=[N-])c1cc(F)cc(Br)c1.Cl>>Cl.[N-]=[N+]=NC[C@@H](N)c1cc(F)cc(Br)c1,,C1COCCO1,,,,val
US20160207949A1,COC(=O)[C@@H]1CCCCN1.COc1cc(C(=O)O)c([N+](=O)[O-])cc1OCc1ccccc1.O=C(Cl)C(=O)Cl>>COC(=O)[C@H]1CCCCN1C(=O)c1cc(OC)c(OC(=O)c2ccccc2)cc1[N+](=O)[O-],,CCN(CC)CC,ClCCl,CN(C)C=O,Cl,val
US20160000760A1,CC1(O)CCNC1.O=S(=O)(Cl)c1ccc(Br)cc1>>CC1(O)CCN(S(=O)(=O)c2ccc(Br)cc2)C1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20110009407A1,COC(=O)C(=CC=CN[C@@H]1CCc2ccccc21)C(=O)OC>>O=C(O)c1cccn([C@@H]2CCc3ccccc32)c1=O,,CO,,O,[H-].[Na+],val
US04247555,COc1cc(OC)c2[nH]c3cc(C(=O)O)nn3c(=O)c2c1.Nc1nnn[nH]1>>COc1cc(OC)c2[nH]c3cc(C(=O)Nc4nnn[nH]4)nn3c(=O)c2c1,,CN(C)C=O,,O,O=C(n1ccnc1)n1ccnc1,val
US20050197340A1,CSc1nc(Cl)c(C(=O)C2CCCC2)c(Cl)n1.NN>>CSc1nc(Cl)c2c(C3CCCC3)n[nH]c2n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20130267510A1,O=[N+]([O-])c1ccc(F)cc1.Oc1cccc2c1COC2>>O=[N+]([O-])c1ccc(Oc2cccc3c2COC3)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030092677A1,O=C1CC(c2cccc([N+](=O)[O-])c2)=Nc2ccc(-c3ccc(F)cc3)cc2N1>>Nc1cccc(C2=Nc3ccc(-c4ccc(F)cc4)cc3NC(=O)C2)c1,[Ni],,,,,val
US20130085144A1,CCOC(=O)c1cc(C#N)c(SC)nc1N>>CSc1nc(N)c(C(=O)O)cc1C#N,,CCO,O,[Li+].[OH-],,val
US20090105307A1,CCN(C[C@H]1COC(C)(C)N1C(=O)OC(C)(C)C)c1ccnc(C(F)(F)F)n1>>CCN(C[C@H](N)CO)c1ccnc(C(F)(F)F)n1,,C1COCCO1,,Cl,,val
US05206240,CC(=O)N1CCC2(CC1)CC(=O)c1c(ccc([N+](=O)[O-])c1O)O2.CI>>COc1c([N+](=O)[O-])ccc2c1C(=O)CC1(CCN(C(C)=O)CC1)O2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080045537A1,C=O.CN(C)CCN(C)c1cccc2[nH]c(CN)nc12.O=C1CCCc2cccnc21>>CN(C)CCN(C)c1cccc2[nH]c(CN(C)C3CCCc4cccnc43)nc12,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04985419,CC(COS(C)(=O)=O)N1c2ccccc2Sc2ccc(C#N)cc21.OC[C@H]1CCCN1>>CC(CN1CCC[C@@H]1CO)N1c2ccccc2Sc2ccc(C#N)cc21,,CCO,,,,val
US05494925,O=C1C2CCCN2S(=O)(=O)N1CCl.Sc1nnnn1-c1ccccc1>>O=C1C2CCCN2S(=O)(=O)N1CSc1nnnn1-c1ccccc1,,CN(C)C=O,,,,val
US20100222321A1,Oc1nnc2c3cc(-c4ccccc4)c(-c4ccc(C5OCCO5)cc4)nc3ccn12>>O=Cc1ccc(-c2nc3ccn4c(O)nnc4c3cc2-c2ccccc2)cc1,,C1COCCO1,Cl,,,val
US20090082254A1,C#CCOc1cccc(C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)c1>>C#CCOc1cccc(C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110245224A1,CC(=O)c1cc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c(N2C[C@H](C)O[C@H](C)C2)c(F)c1ON=C(C)C>>Cc1noc2c(F)c(N3C[C@H](C)O[C@H](C)C3)c(CO)cc12,,CCO,,Cl,,val
US20130079335A1,CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(-c3ccc(C=O)cc3)ccc2-n2c(C)nnc21.CN1CCNCC1>>CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(-c3ccc(CN4CCN(C)CC4)cc3)ccc2-n2c(C)nnc21,,CC(=O)O,ClCCl,O=C([O-])O.[Na+],,val
US20070191340A1,Brc1ccc(CN2CCO[C@@H](c3ccccc3)C2)cc1.OB(O)c1ccccc1C(F)(F)F>>FC(F)(F)c1ccccc1-c1ccc(CN2CCO[C@@H](c3ccccc3)C2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US05118811,O=C(O)CCC(=O)N1CCCC1=O.OC[C@@H]1CCCN1>>O=C1CCCN1C(=O)CCC(=O)N1CCC[C@H]1CO,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20140275071A1,BrCCOC1CCCCO1.Cn1c(=O)[nH]c(=O)c2c1nc(Br)n2Cc1ccc(Cl)cc1>>Cn1c(=O)n(CCOC2CCCCO2)c(=O)c2c1nc(Br)n2Cc1ccc(Cl)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140135316A1,CCOC(=O)CC(C)N.O=[N+]([O-])c1ccccc1F>>CCOC(=O)CC(C)Nc1ccccc1[N+](=O)[O-],,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20090253677A1,CCOC(=O)c1nc2n(c(=O)c1O)CC1CCC(C1)C2N(C)C(=O)OCc1ccccc1.O=C(OC(=O)c1ccccc1)c1ccccc1>>CCOC(=O)c1nc2n(c(=O)c1OC(=O)c1ccccc1)CC1CCC(C1)C2N(C)C(=O)OCc1ccccc1,,c1ccncc1,,,,val
US20100029611A1,CCOC(=O)CC(=O)OCC.Fc1cc(CC(CBr)CBr)ccc1-c1nc2ccc(C3(c4ccccc4)CC3)nc2s1>>CCOC(=O)C1(C(=O)OCC)CC(Cc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20150259354A1,CNc1ccccc1-c1ccnc2c(C#N)c(-c3ccc(Oc4ccccc4)cc3)nn12>>CNc1ccccc1C1CCNc2c(C#N)c(-c3ccc(Oc4ccccc4)cc3)nn21,,CCO,,[BH4-].[Na+],,val
US20080234349A1,COC(=O)COc1ccc2c(ccn2S(=O)(=O)c2ccc(-c3cc(C(F)(F)F)n(C)n3)s2)c1>>Cn1nc(-c2ccc(S(=O)(=O)n3ccc4cc(OCC(=O)O)ccc43)s2)cc1C(F)(F)F,,C1CCOC1,O,Cl,[K+].[OH-],val
US20120232056A1,COC(=O)c1ccc2nc(-c3cc[nH]c3)c(N3CCC[C@@H]3C)nc2c1>>C[C@H]1CCCN1c1nc2cc(C(=O)O)ccc2nc1-c1cc[nH]c1,,CO,O,[Na+].[OH-],,val
US20130059863A1,Cc1nc(N2CC[C@@H](N3CCC[C@@H]3C)C2)ccc1N1CCCC2(CCN(C(=O)OC(C)(C)C)CC2)C1=O.Cl>>Cc1nc(N2CC[C@@H](N3CCC[C@@H]3C)C2)ccc1N1CCCC2(CCNCC2)C1=O.Cl,,CCO,CO,,,val
US20140350002A1,Cn1c(=O)n(CC(C)(C)C)c2ccc(C34CC5CNCC5C3C4(F)F)nc21.O=C(O)c1ccon1>>Cn1c(=O)n(CC(C)(C)C)c2ccc(C34CC5CN(C(=O)c6ccon6)CC5C3C4(F)F)nc21,,CC#N,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130039906A1,Brc1cc2c(-c3ccccc3)nn(C3CCCCO3)c2cn1.CCCC[Sn](CCCC)(CCCC)C1=CCOC1=O>>O=C1C=C(c2cc3c(-c4ccccc4)nn(C4CCCCO4)c3cn2)CO1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,,,,val
US20110195977A1,COc1ccc(/C=C/C(=O)Nc2cccc(O)c2)cc1O.ClCc1cccnc1>>COc1ccc(/C=C/C(=O)Nc2cccc(OCc3cccnc3)c2)cc1O,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20100292255A1,C[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(Cn2c(Sc3nc4cccc(Cl)c4s3)nc3c(N)ncnc32)CC1>>C[C@@H](N)C(=O)N1CCC(Cn2c(Sc3nc4cccc(Cl)c4s3)nc3c(N)ncnc32)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070254912A1,COc1ccc2c(c1)nc(C(F)(F)F)n2-c1ccc(NC(=O)C(F)(F)F)nc1>>COc1ccc2c(c1)nc(C(F)(F)F)n2-c1ccc(N)nc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20080085890A1,CC=O.O=C1NC(=O)c2ccc(I)cc2/C1=C/Nc1ccc(N2CCNCC2)cc1>>CCN1CCN(c2ccc(N/C=C3\C(=O)NC(=O)c4ccc(I)cc43)cc2)CC1,,CN1CCCC1=O,ClCCl,CC(=O)O,O=C([O-])O.[Na+],val
US05840913,CO.c1ccc(-c2cc(-c3ccccc3)[nH]n2)cc1>>Cn1nc(-c2ccccc2)cc1-c1ccccc1,O=S(=O)(O)O,,,,,val
US20130085144A1,CN1CCN(c2ccc(C(=O)Nc3nn(C(=O)c4ccc(N5CCN(C)CC5)cc4N(C(=O)C(F)(F)F)C4CCOCC4)c4ncc(Sc5cc(F)cc(F)c5)nc34)c(N(C(=O)C(F)(F)F)C3CCOCC3)c2)CC1>>CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ncc(Sc5cc(F)cc(F)c5)nc34)c(NC3CCOCC3)c2)CC1,,CO,,CCN(CC)CC,,val
US06004982,CCN(CC)CC.COc1cccc(CC(O)C2CCNCC2)c1OC.CS(=O)(=O)Cl>>COc1cccc(CC(O)C2CCN(CS(N)(=O)=O)CC2)c1OC,,ClCCl,,,,val
US07091199B1,BrCCCOc1cccc(-c2noc3ccsc23)c1.NC1Cc2ccccc2C1>>c1cc(OCCCNC2Cc3ccccc3C2)cc(-c2noc3ccsc23)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150291598A1,CI.Nc1ccc(Cl)nc1>>CNc1ccc(Cl)nc1,,C1CCOC1,,[H-].[Na+],,val
US20020028938A1,CC(=O)CO.CS(=O)(=O)c1ccc(-c2cnn(-c3ccc(F)c(F)c3)c(=O)c2O)cc1>>CC(=O)COc1c(-c2ccc(S(C)(=O)=O)cc2)cnn(-c2ccc(F)c(F)c2)c1=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06121264,Nc1cccc(CO)c1.O=[N+]([O-])c1cc(C(F)(F)F)c(F)cc1F>>O=[N+]([O-])c1cc(C(F)(F)F)c(F)cc1Nc1cccc(CO)c1,,CCO,,,,val
US20130231328A1,CC(C)(C)OC(=O)NCCc1cc2c(OC3CCC(N4CCOCC4)CC3)ncnc2s1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.c1nc(OC2CCC(N3CCOCC3)CC2)c2c3c(sc2n1)CCNC3,,ClCCl,O,,,val
US20120010184A1,CC(C)(CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)c1nnc(N)s1.CC(C)(SC[C@H]1CCCCO1)C(=O)O>>CC(C)(SC[C@H]1CCCCO1)C(=O)Nc1nnc(C(C)(C)CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)s1,CN(C)C=O,Cc1ccccc1,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US20140051676A1,BrCC1CC1.CC(C)(C)OC(=O)N1CCC(CO)CC1>>CC(C)(C)OC(=O)N1CCC(COCC2CC2)CC1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20140057893A1,CC(C)(C)N=C=O.c1cc(-n2cnnn2)ccc1OCC[C@@H]1C[C@@H]1C1CCNCC1>>CC(C)(C)NC(=O)N1CCC([C@H]2C[C@H]2CCOc2ccc(-n3cnnn3)cc2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05134128,Br[Mg]CCCCC/C=C/CCc1ccccc1.C[Si](C)(C)c1cc(C=O)co1>>C[Si](C)(C)c1cc(C(O)CCCCC/C=C/CCc2ccccc2)co1,,C1CCOC1,,,,val
US20110144105A1,CCOCCS(=O)(=O)c1ccc(C(=CC2CCCC2)c2cc3cc(F)cnc3[nH]2)cc1>>CCOCCS(=O)(=O)c1ccc(C(CC2CCCC2)c2cc3cc(F)cnc3[nH]2)cc1,[Pd],CO,,,,val
US20070259965A1,CC(C)C[C@H](NC(=O)c1cccc2c1CCNC2)C(=O)NCCCNS(=O)(=O)c1ccc(F)cc1Cl.ClCc1ccccc1>>CC(C)C[C@H](NC(=O)c1cccc2c1CCN(Cc1ccccc1)C2)C(=O)NCCCNS(=O)(=O)c1ccc(F)cc1Cl,,ClCCl,,CCN(CC)CC,,val
US20160009667A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1noc2cc(CBr)c(Cl)cc12.CC1(C)CCc2cc(O)ccc2O1>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1noc2cc(COc3ccc4c(c3)CCC(C)(C)O4)c(Cl)cc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030139409A1,CC(=O)Cl.CN(C)CCNC(=O)c1cccc2nc3ccc4c(N)cccc4c3nc12>>CC(=O)Nc1cccc2c1ccc1nc3cccc(C(=O)NCCN(C)C)c3nc12,,C1CCOC1,,c1ccncc1,,val
US20060189636A1,O=C(OO)c1cccc(Cl)c1.OC[C@@H]1CC=C[C@@H]1O>>OC[C@@H]1C[C@@H]2O[C@@H]2[C@@H]1O,,ClCCl,,,,val
US04115367,CC(=O)Oc1ccc(C(F)(F)C(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)c2ccc(OC(C)=O)cc2)cc1>>Oc1ccc(C(F)(F)C(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)c2ccc(O)cc2)cc1,,CO,,Cl,,val
US20070281917A1,C1CC2(CCN1)OCCO2.CN(C)S(=O)(=O)Cl>>CN(C)S(=O)(=O)N1CCC2(CC1)OCCO2,,C1CCOC1,,CCN(CC)CC,,val
US04906624,COC(=O)c1c(C(C)C)nc(C(C)C)c(CC=CO)c1-c1ccc(F)cc1>>CC(C)c1nc(C(C)C)c(C(=O)O)c(-c2ccc(F)cc2)c1CC=CO,,CCCCO,,[K+].[OH-],,val
US05705504,CCOC(=O)CBr.COc1ccccc1N>>CCOC(=O)CNc1ccccc1OC,,ClC(Cl)Cl,,,,val
US20140206680A1,CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1nc(-c2cc3ccncc3s2)c2c(c1F)CN(C(=O)OC(C)(C)C)C2=O.O=C(O)C(F)(F)F>>N[C@H]1CCCC[C@H]1Nc1nc(-c2cc3ccncc3s2)c2c(c1F)CNC2=O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20080114062A1,CN(C)C(=O)CCCC#Cc1cccc(C(=O)O)c1.NCCF>>CN(C)C(=O)CCCC#Cc1cccc(C(=O)NCCF)c1,,ClCCl,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US20020119992A1,CC(C)[C@@H](O)C(=O)N1CCC[C@H]1C(=O)NCc1cc(Cl)ccc1CNC(=O)OC(C)(C)C>>CC(C)[C@@H](O)C(=O)N1CCC[C@H]1C(=O)NCc1cc(Cl)ccc1CN,,CCOC(C)=O,,,,val
US06156767,CON(C)C(=O)Cc1cccnc1>>O=CCc1cccnc1,,C1CCOC1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20100173905A1,BrBr.COC(=O)c1cc(OC)c(C)c(OC)c1>>COC(=O)c1cc(OC)c(C)c(OC)c1Br,,ClCCl,,,,val
US20040058964A1,C=C[Sn](CCCC)(CCCC)CCCC.O=c1c(I)c(OCc2ccccc2)ccn1Cc1ccccc1>>C=Cc1c(OCc2ccccc2)ccn(Cc2ccccc2)c1=O,,CC#N,,CN(C)C=O,,val
US20140200227A1,CC(C)(O)c1cc(F)cc(F)c1.CC(C)OB1OC(C)(C)C(C)(C)O1>>CC(C)(O)c1cc(F)c(B2OC(C)(C)C(C)(C)O2)c(F)c1,,C1CCOC1,,[Li]CCCC,,val
US20160152626A1,CNC(C)(C)C.COc1cc2c(cc1C=C(C)C)-c1c(c(C(=O)O)nn1-c1cccs1)CO2>>COc1cc2c(cc1C=C(C)C)-c1c(c(C(=O)N(C)C(C)(C)C)nn1-c1cccs1)CO2,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110263610A1,CC(C)(C)OC(=O)N1CC=C(c2nn(C3CCCCO3)cc2CO)CC1>>CC(C)(C)OC(=O)N1CC=C(c2nn(C3CCCCO3)cc2C=O)CC1,O=[Mn]=O,ClCCl,,,,val
US20050059650A1,CCNCC1CCN(C(=O)OC(C)(C)C)CC1.CS(=O)(=O)c1ccc(-c2noc3c(Cl)ncnc23)cc1>>CCN(CC1CCN(C(=O)OC(C)(C)C)CC1)c1ncnc2c(-c3ccc(S(C)(=O)=O)cc3)noc12,,C1CCOC1,,[H-].[Na+],,val
US20070191603A1,COC(=O)c1ccc2c(c1)N(S(=O)(=O)c1cc(Cl)ccc1OC)CCO2>>COc1ccc(Cl)cc1S(=O)(=O)N1CCOc2ccc(C(=O)O)cc21,,C1CCOC1,CO,[Na+].[OH-],,val
US20030199552A1,CCOC(=O)c1cc2cc3oc(=O)[nH]c3cc2o1>>O=C(O)c1cc2cc3oc(=O)[nH]c3cc2o1,,CCO,,[K+].[OH-],,val
US20020169317A1,CC(=O)NCCOc1cccc2c1c1cc(C)cc3c1n2C(c1ccccc1)CO3>>CCNCCOc1cccc2c1c1cc(C)cc3c1n2C(c1ccccc1)CO3,,C1CCOC1,,CO,,val
US20160107980A1,C=CC(C)c1ccccc1.C=CC/C=C(\C)CC/C=C(\C)CCC=C(C)C>>CC(C)CCCC(C)CCCC(C)CCCCC(C)c1ccccc1,[Pd],,,,,val
US05998433,CN(C)Cc1cc2c(o1)CN(C(=O)CCCCCc1ccc(F)cc1)CC2.Cl>>CN(C)Cc1cc2c(o1)CN(C(=O)CCCCCc1ccc(F)cc1)CC2.Cl,,CCOC(C)=O,CO,,,val
US06881736B1,CCOC(=O)CC(Cc1ccc(OCCc2cccc(NC)n2)cc1)c1ccc(C(F)(F)F)cc1>>CNc1cccc(CCOc2ccc(CC(CC(=O)O)c3ccc(C(F)(F)F)cc3)cc2)n1,,CO,,[Na+].[OH-],,val
US20080262042A1,CN(Cc1c[nH]c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C.CS(=O)(=O)c1cccc(S(=O)(=O)Cl)c1>>CN(Cc1cn(S(=O)(=O)c2cccc(S(C)(=O)=O)c2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C,,C1CCOC1,O,C1COCCOCCOCCOCCO1,[H-].[Na+],val
US20090311217A1,CNC(=O)Nc1ccc2c(c1)C(=O)CO2.COCCOc1ccc2[nH]c(-c3c(C)nn(C)c3C)c(C=O)c2c1>>CNC(=O)Nc1ccc2c(c1)C(=O)/C(=C/c1c(-c3c(C)nn(C)c3C)[nH]c3ccc(OCCOC)cc13)O2,Cl,CCO,CCOC(C)=O,,,val
US20060142263A1,O=[N+]([O-])c1ccc(F)cc1F.Oc1ccccn1>>O=c1ccccn1-c1ccc([N+](=O)[O-])c(F)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05100891,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1CCc2c1[nH]c1ccccc21>>CC(C)(C)OC(=O)n1c2c(c3ccccc31)CCC2=O,CN(C)c1ccncc1,CC#N,,,,val
US20080076705A1,CC(C)(C)OC(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1>>CC(C)(C)OC(=O)c1cc(N)cc(C(=O)O)c1,[Pd],CCOC(C)=O,,,,val
US06645976B1,CCOC(=O)COc1cccn2c(Cc3cccc(Cl)c3)c(CC)c(C(=O)C(N)=O)c12>>CCOC(=O)COc1cccn2c(Cc3ccccc3)c(C)c(C(=O)C(N)=O)c12,,CCCCCC,CCOC(C)=O,,,val
US20120178748A1,CNc1ccc2cccnc2c1[N+](=O)[O-]>>CNc1ccc2cccnc2c1N,[Ni],CO,,NN,O,val
US20130045986A1,CC(C)OC(=O)Cl.CS(=O)(=O)c1ccc(-c2ccc3oc(C4CCNCC4)nc3c2)c(F)c1>>CC(C)OC(=O)N1CCC(c2nc3cc(-c4ccc(S(C)(=O)=O)cc4F)ccc3o2)CC1,,ClCCl,O,Cc1ccccc1,O=C(O)C(F)(F)F,val
US20140114086A1,C=C[C@H](O)CCCCC.CC(C)(C)[Si](C)(C)Cl>>C=C[C@@H](CCCCC)O[Si](C)(C)C(C)(C)C,,ClCCl,,O,c1c[nH]cn1,val
US20100190763A1,C[C@H]1CNCCN1C(=O)OC(C)(C)C.N#Cc1ccc(F)cc1>>C[C@H]1CN(c2ccc(C#N)cc2)CCN1C(=O)OC(C)(C)C,,CCOC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20020137744A1,CC1(C)SCCNC1C(=O)O[Si](C)(C)C(C)(C)C.CN1CCOCC1.O=S(=O)(Cl)c1ccc2oc(-c3ccncc3)cc2c1>>CC1(C)SCCN(S(=O)(=O)c2ccc3oc(-c4ccc(N)cc4)cc3c2)C1C(=O)O[Si](C)(C)C(C)(C)C,,ClCCl,,O,,val
US20060128729A1,CCCc1nn(C)c2c(-c3ccc(O)c(C)c3)nc(-c3ccc(OC)c(O)c3)nc12.Cc1ccccc1O>>CCCc1nn(C)c2c(-c3ccc(O)c(C)c3)nc(-c3ccc(OC)c(OC)c3)nc12,,O=[N+]([O-])c1ccccc1,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20080096861A1,CN(CC(=O)OCc1ccccc1)C1CCCc2cccnc21>>CN(CC(=O)O)C1CCCc2cccnc21,[Pd],CO,,,,val
US20030120080A1,CC[C@@H](C(N)=O)N1CC(CN)CC1=O.S=C=C1N=CC=N1>>CC[C@@H](C(N)=O)N1CC(CN=C=S)CC1=O,,CN(C)C=O,,,,val
US05663346,O=C1Nc2ccc(O)cc2C1=Cc1c[nH]c2ncccc12.OCC(O)CCl>>O=C1Nc2ccc(OCC(O)CO)cc2C1=Cc1c[nH]c2ncccc12,,Cc1ccccc1,,O,,val
US20120053166A1,CC(C)N1CCNCC1.Cc1ccc(S(=O)(=O)n2ncc3c(-c4nnc(CCl)o4)cc(-c4cnc(Cl)c(NS(C)(=O)=O)c4)cc32)cc1>>CC(C)N1CCN(Cc2nnc(-c3cc(-c4cnc(Cl)c(NS(C)(=O)=O)c4)cc4[nH]ncc34)o2)CC1,,CC(C)O,,[Na+].[OH-],,val
US04885292,CC(C)C[C@@H](C=O)NC(=O)OC(C)(C)C.c1cscn1>>CC(C)C[C@H](NC(=O)OC(C)(C)C)C(O)c1nccs1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20090048203A1,CC(=O)O[C@H]1C=C[C@@H](O)C1>>CC(=O)OC1C=CC(=O)C1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20100215618A1,COC(=O)N[C@H](C(=O)O)C(C)C.O=C(Nc1ccc(CN2CCS(=O)(=O)CC2)cc1)c1ccc(-c2ccc(-c3cnc([C@@H]4CCCN4)[nH]3)cc2)cc1>>COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc(-c3ccc(C(=O)Nc4ccc(CN5CCS(=O)(=O)CC5)cc4)cc3)cc2)[nH]1)C(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04391815,CC(C)(C)C(=O)Cl.CC1(C)Oc2ccc(C#N)cc2[C@@H](N2CCCC2)[C@@H]1O>>CC(C)(C)C(=O)O[C@H]1[C@H](N2CCCC2)c2cc(C#N)ccc2OC1(C)C,CN(C)c1ccncc1,ClCCl,,,,val
US20080262042A1,CN(Cc1cn(S(=O)(=O)c2cccnc2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C>>CN(Cc1c[nH]c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C,,C1CCOC1,CC(C)O,[Na+].[OH-],,val
US20100240634A1,CCOC(=O)C(C=O)n1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1>>OCC(CO)n1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1,,C1CCOC1,,CCO,[BH4-].[Na+],val
US20110251190A1,FC1(F)CC2(NC1=S)c1cc(-c3cccnc3)ccc1Oc1ncc(-c3cccnc3)cc12.N>>NC1=NC2(CC1(F)F)c1cc(-c3cccnc3)ccc1Oc1ncc(-c3cccnc3)cc12,,C1CCOC1,,,,val
US04808586,COc1ccc(OC)c2[nH]c(-c3ccccc3)nc12>>Oc1ccc(O)c2[nH]c(-c3ccccc3)nc12,,Cc1ccccc1,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20130052281A1,FC(F)(F)c1ccc(/C=C/c2cc(OCc3ccccc3)c(OCc3ccccc3)nn2)cc1C(F)(F)F>>O=c1[nH]nc(CCc2ccc(C(F)(F)F)c(C(F)(F)F)c2)cc1O,[Pd],C1CCOC1,,,,val
US20060069088A1,CC(C)(C)OC(=O)N1CCC(c2cc(O)no2)CC1.Cc1ccccc1S(=O)(=O)Cl>>Cc1ccc(S(=O)(=O)Oc2cc(C3CCN(C(=O)OC(C)(C)C)CC3)on2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20080021024A1,N#Cc1ccc(CNC(=O)c2cc(N)ncn2)cc1.O=C(Cl)Oc1ccccc1>>N#Cc1ccc(CNC(=O)c2cc(NC(=O)Oc3ccccc3)ncn2)cc1,,c1ccncc1,,Cl,,val
US20050090534A1,CC(CC(=O)O)c1oc(Cl)nc1-c1ccc(Cl)cc1.c1ccc2[nH]cnc2c1>>O=C(O)CCCc1oc(-n2cnc3ccccc32)nc1-c1ccc(Cl)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06019986,BrC(Br)Br.Nc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)cc1C1CC1(Br)Br>>FC(F)(F)c1cc(Cl)c(-n2cc(C3CC3(Br)Br)c(Br)n2)c(Cl)c1,,CC#N,,CC(C)(C)ON=O,,val
US20080221110A1,C=C(C(=O)OC)c1c(F)ccc2ccc(OC)nc12.CC(C)(C)OC(=O)NC1CCNCC1>>COC(=O)C(CN1CCC(NC(=O)OC(C)(C)C)CC1)c1c(F)ccc2ccc(OC)nc12,,CN(C)C=O,,CN(C)C(=N)N(C)C,,val
US20120178751A1,O=[N+]([O-])c1cc(-c2cn3nc(Cl)ccc3n2)ccc1C(F)(F)F>>Nc1cc(-c2cn3nc(Cl)ccc3n2)ccc1C(F)(F)F,[Fe],CCO,O,CC(=O)O,,val
US20100137587A1,CC(C)CN(C(=O)c1nc2ccccc2[nH]1)[C@H]1C[C@@H](C(=O)N2CCOCC2)CN(C(=O)OC(C)(C)C)C1.COCCCCOS(C)(=O)=O>>COCCCCn1c(C(=O)N(CC(C)C)[C@H]2C[C@@H](C(=O)N3CCOCC3)CN(C(=O)OC(C)(C)C)C2)nc2ccccc21,,CC(=O)N(C)C,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090005380A1,O=C([C@@H]1CC[C@H](O)CC1)N1CCN(C2CCC2)CC1.Oc1ccc(-n2cncn2)cc1>>O=C([C@@H]1CC[C@@H](Oc2ccc(-n3cncn3)cc2)CC1)N1CCN(C2CCC2)CC1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020091264A1,CCOC(=O)C[C@@H]1Cc2ccc(OCCCNc3cc(OCC)ccn3)cc2Cc2ccccc21>>CCOc1ccnc(NCCCOc2ccc3c(c2)Cc2ccccc2[C@H](CC(=O)O)C3)c1,,CCO,,Cl,[Na+].[OH-],val
US20070149561A1,CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(N)cc2)n1.O=C=Nc1ccccc1>>CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)n1,CCN(CC)CC,C1CCOC1,,,,val
US06077866,NC(N)=S.O=C(c1ccc(Cl)cc1)c1ccc(CBr)cc1>>NC(=[NH2+])SCc1ccc(C(=O)c2ccc(Cl)cc2)cc1.[Br-],,CC(C)=O,,,,val
US20100048568A1,CCOC(=O)CN(CCNN1C(=O)c2ccccc2C1=O)C(=O)OCc1ccccc1>>O=C(OCc1ccccc1)N1CCN(N2C(=O)c3ccccc3C2=O)C(=O)C1,,c1ccc(Oc2ccccc2)cc1,,,,val
US20050288357A1,C=CCBr.COC(=O)CO>>C=CCOCC(=O)OC,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US03963745,CC(=O)OC(C)=O.Nc1ccc(C(=O)NC2CCN(C3CCCCC3)C2)cc1>>CC(=O)Nc1ccc(C(=O)NC2CCN(C3CCCCC3)C2)cc1,,ClC(Cl)Cl,,,,val
US20150210681A1,CCOC(=O)C1CCNCC1.Clc1cncc(Cl)n1>>CCOC(=O)C1CCN(c2cncc(Cl)n2)CC1,,C1COCCO1,,CCN(CC)CC,,val
US20110021520A1,CC(C)(C)OC(=O)NC1=NC(c2cc(N=[N+]=[N-])ccc2F)(C(F)F)COC1>>CC(C)(C)OC(=O)NC1=NC(c2cc(N)ccc2F)(C(F)F)COC1,[Pd],C1CCOC1,CCO,,,val
US20160002259A1,C=Cc1cccc(-n2cnnn2)c1.O=C(OO)c1cccc(Cl)c1>>c1cc(C2CO2)cc(-n2cnnn2)c1,,ClCCl,,,,val
US05418229,CNCCC(=O)N1c2ccccc2NC(=O)c2ccccc21.Cc1ccc(CCBr)cc1>>Cc1ccc(CCN(C)CCC(=O)N2c3ccccc3NC(=O)c3ccccc32)cc1,,CC#N,,O=C([O-])O.[Na+],,val
US20050131014A1,COS(=O)(=O)OC.Nc1cccc(-c2c(C(=O)c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1>>CNc1cccc(-c2c(C(=O)c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1,,CCO,,,,val
US06204261B1,CC(C)O.O=CC(CC(=O)O)NC(=O)C1CCCN2C(=O)CCC(NC(=O)c3ccccc3)C(=O)N12>>CC(C)OC1OC(=O)CC1NC(=O)C1CCCN2C(=O)CCC(NC(=O)c3ccccc3)C(=O)N12,,CC(C)O,,Cc1ccc(S(=O)(=O)O)cc1,O=C([O-])O.[Na+],val
US20080269293A1,CC(=O)c1ccc([N+](=O)[O-])cc1>>CC(O)c1ccc([N+](=O)[O-])cc1,,C1CCOC1,CO,[BH4-].[Na+],,val
US20070179148A1,CC(C)(C)OC(=O)N[C@@H]1CCC[C@H](C(=O)O)C1.Clc1ccc(N2CCNCC2)cc1Cl>>CC(C)(C)OC(=O)N[C@H]1CCC[C@@H](C(=O)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US05880126,CN(CCc1ccccc1)C(=O)CBr.Cc1c(C(=O)OC(C)C)ncc2[nH]c3cccc(OCc4ccccc4)c3c12>>Cc1c(C(=O)OC(C)C)ncc2c1c1c(OCc3ccccc3)cccc1n2CC(=O)N(C)CCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US06245743B1,C(=NC1CCCCC1)=NC1CCCCC1.CCN(C(C)C)C(C)C.Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@@H](NC(=O)OC(C)(C)C)C(=O)O)cc1.NCC(=O)OCc1ccccc1.On1nnc2ccccc21>>Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)NCC(=O)OCc2ccccc2)cc1,,ClCCl,,Cl,,val
US20060105997A1,CC(C)(C)[C@H](N)C(=O)N1CC(c2cc(F)ccc2F)=C[C@H]1c1ccccc1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CC(C)(C)[C@H](NC(=O)Oc1ccc([N+](=O)[O-])cc1)C(=O)N1CC(c2cc(F)ccc2F)=C[C@H]1c1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US06265446B1,CC(C)CNNC(=O)[C@H](CC(C)C)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1.O=S(=O)(Cl)CCCCl>>CC(C)C[C@@H](C(=O)NN(CC(C)C)S(=O)(=O)CCCCl)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1,,CCOC(C)=O,ClCCl,c1ccncc1,,val
US20160024072A1,CN(C)c1ncc(N(C(=O)OC(C)(C)C)c2ccc(Oc3ccc(F)cn3)cc2)c(Cc2ccc(F)cc2)n1>>CN(C)c1ncc(Nc2ccc(Oc3ccc(F)cn3)cc2)c(Cc2ccc(F)cc2)n1,,C1COCCO1,Cl,O=C([O-])O.[Na+],,val
US20060004017A1,COc1ccc2[nH]c(C(F)(F)F)cc2c1>>Oc1ccc2[nH]c(C(F)(F)F)cc2c1,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20050004149A1,CCOC(=O)C1CCN(c2cc(-c3c(-c4ccco4)nc(N)nc3-c3ccco3)ccn2)CC1>>Nc1nc(-c2ccco2)c(-c2ccnc(N3CCC(C(=O)O)CC3)c2)c(-c2ccco2)n1,,CO,,[Na+].[OH-],,val
US20140163008A1,C[Si](C)(C)C#Cc1ccc2c(c1)COc1cc(F)ccc1C2=C(C#N)C1CC1>>C#Cc1ccc2c(c1)COc1cc(F)ccc1C2=C(C#N)C1CC1,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US20130237535A1,CCN(CC1(O)CCN(S(=O)(=O)c2ccc(Br)cc2)CC1)C(=O)CCl>>CCN1CC2(CCN(S(=O)(=O)c3ccc(Br)cc3)CC2)OCC1=O,,CS(C)=O,,[H-].[Na+],,val
US20080004271A1,NC(=O)c1sc2ncnc(-c3cccc(N)c3)c2c1N.Nc1cccnc1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>NC(=O)c1sc2ncnc(-c3cccc(NC(=O)Nc4cccnc4)c3)c2c1N,,C1CCOC1,,CCN(CC)CC,,val
US20040082611A1,C[C@H]1CN(S(=O)(=O)c2cc3cc(Cl)ccc3n2S(=O)(=O)c2ccccc2)C[C@@H](C)N1.O=C(Cl)c1ccc(Br)cc1>>CC1CN(S(=O)(=O)c2cc3cc(Cl)ccc3n2S(=O)(=O)c2ccccc2)CC(C)N1C(=O)c1ccc(Br)cc1,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20100125058A1,CCOC(=O)C=Cc1cc2ccc(F)cc2c(Oc2ccc(S(=O)(=O)CC)cc2)c1C>>CCOC(=O)CCc1cc2ccc(F)cc2c(Oc2ccc(S(=O)(=O)CC)cc2)c1C,[Pd],CCOC(C)=O,,,,val
US20020160931A1,CC(=O)Cl.Cc1ccc(CC2c3cc(C)ccc3C(C)(C)C2C)cc1>>CC(=O)C1=C(C)c2cc(C)ccc2C1(C)C,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US06350878B1,CC(C)(C)[Si](C)(C)Cl.CC1(O)OCC[C@@H]1O[Si](C)(C)C(C)(C)C>>CC(=O)[C@H](CCO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C,,CN(C)C=O,,c1c[nH]cn1,,val
US06017919,CCCCCBr.COC(=O)c1cccc(O)c1C(=O)OC>>CCCCCOc1cccc(C(=O)OC)c1C(=O)OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05905074,CC(C)(C)O[C@H]1CCCC2C(O)CCC[C@@]21C>>CC(C)(C)O[C@H]1CCC[C@H]2C(=O)CCC[C@]12C,,CCOCC,ClCCl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20150232459A1,COC(=O)NCCCc1cc([C@@H](C)N(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)C[C@@H](COS(C)(=O)=O)O2)C2CC2)cc(OC)n1.O=C1NC(=O)c2ccccc21>>COC(=O)NCCCc1cc([C@@H](C)N(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)C[C@@H](CN3C(=O)c4ccccc4C3=O)O2)C2CC2)cc(OC)n1,,CN(C)C=O,,O,[K],val
US20140010783A1,Cn1c(=O)ccn(-c2ccc([N+](=O)[O-])cc2Cl)c1=O>>Cn1c(=O)ccn(-c2ccc(N)cc2Cl)c1=O,[Zn],C1CCOC1,,[Cl-].[NH4+],,val
US20100093707A1,O.O=C(O)c1cccc(I)c1.[Li]CCCC>>CC(C)C(=O)c1cccc(C(=O)O)c1,,CCCCCC,,C1CCOC1,,val
US20060264460A1,N#Cc1c[nH]c2c(Br)cc([N+](=O)[O-])cc2c1=O.O=C(Cl)C(=O)Cl>>N#Cc1cnc2c(Br)cc([N+](=O)[O-])cc2c1Cl,,ClCCCl,,CN(C)C=O,,val
US20030036655A1,O=C(Nc1ccc(CC2CCNCC2)cc1)C(F)(F)F.O=S(=O)(Cl)c1ccccc1>>O=C(Nc1ccc(CC2CCN(S(=O)(=O)c3ccccc3)CC2)cc1)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US05736487,CI.Cc1cc(OCc2nc3ccccc3s2)ccc1N.S=C=S>>CSC(=S)Nc1ccc(OCc2nc3ccccc3s2)cc1C,,CN(C)C=O,O,[K+].[OH-],,val
US20120041208A1,CCOC(=O)c1cn(-c2nc(N)c(F)cc2F)c2c(Cl)c(NCC(O)COC3CN(C(=O)OCc4ccccc4)C3)c(F)cc2c1=O>>CCOC(=O)c1cn(-c2nc(N)c(F)cc2F)c2c(Cl)c(NCC(O)COC3CNC3)c(F)cc2c1=O,[Pd],CO,,,,val
US20130190289A1,CC[C@H](Nc1cc(C#CC(C)(C)C)sc1C(=O)OC)C(=O)N1CCOCC1.O=C(Cl)c1ccc(Cl)cc1Cl>>CC[C@@H](C(=O)N1CCOCC1)N(C(=O)c1ccc(Cl)cc1Cl)c1cc(C#CC(C)(C)C)sc1C(=O)OC,,CO,ClCCCl,c1ccncc1,,val
US20070004772A1,CC(C)Cn1nc2c(I)c(Br)ccn2c1=O.OB(O)c1ccc(Cl)cc1>>CC(C)Cn1nc2c(-c3ccc(Cl)cc3)c(Br)ccn2c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US04140785,CCC(=O)Cl.Cn1nc(N)c2sc3ccccc3c21>>CCC(=O)Nc1nn(C)c2c1sc1ccccc12,,c1ccncc1,,ClCCl,,val
US04814265,COS(=O)(=O)C(F)(F)F.COc1nc2cccccc-2n1>>COC1[NH+]=C2C=CC=CC=C2N1C.O=S(=O)([O-])C(F)(F)F,,CCOC(C)=O,,COc1ccccc1,,val
US20120196845A1,CCOC(=O)C1CCN(c2ccccc2)C(=O)C1>>O=C1CC(CO)CCN1c1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20160185778A1,CC(C)(C)OC(=O)N1CCc2[nH]nc(CO)c2C1>>OCc1n[nH]c2c1CNCC2,,C1COCCO1,,Cl,,val
US20120258953A1,CC(C)(C)OC(=O)N1CC[C@@H](O)C[C@H]1c1ccc(F)cc1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CC[C@@H](OS(C)(=O)=O)C[C@H]1c1ccc(F)cc1,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US07541374B2,O=S(Cl)Cl.OCn1cnc(C(F)(F)C(F)(F)F)n1>>FC(F)(F)C(F)(F)c1ncn(CCl)n1,,ClCCl,,,,val
US20080139595A1,BrBr.CC(=O)Nc1cc(F)c(Oc2ccnc3[nH]ccc23)c(F)c1>>CC(=O)Nc1cc(F)c(Oc2ccnc3[nH]cc(Br)c23)c(F)c1,,CC(=O)O,ClCCl,,,val
US04692447,CC(=O)Nc1ccc2ccc(CC(=O)O)c(=O)c-2cc1>>CC(=O)NC1CCC2=C(CC1)C(=O)C(CC(=O)O)C=C2,[Zn],CC(=O)O,,,,val
US04870092,BrBr.CC(=O)C(C)(C)Cc1ccc(Cl)cc1Cl>>CC(C)(Cc1ccc(Cl)cc1Cl)C(=O)CBr,,ClC(Cl)Cl,,,,val
US20100204196A1,CCN(CC)CC(=O)N1CCc2cc(OC)c([N+](=O)[O-])cc21>>CCN(CC)CC(=O)N1CCc2cc(OC)c(N)cc21,[Pd],CCO,,,,val
US20020177594A1,CC(C)(C)OC(=O)C(CCCCCO[Si](C)(C)C(C)(C)C)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)C(CCCCCO)C(=O)OC(C)(C)C,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090118338A1,CC(C)(C)c1ccc(C(=O)Nc2cccc(S(C)(=O)=O)c2)c(Oc2ccc(F)cc2Cl)c1.CI>>CN(C(=O)c1ccc(C(C)(C)C)cc1Oc1ccc(F)cc1Cl)c1cccc(S(C)(=O)=O)c1,,CN(C)C=O,,[H-].[Na+],,val
US20150299123A1,COC(=O)C1CCNCC1.ClCc1cn2nc(Cl)ccc2n1>>COC(=O)C1CCN(Cc2cn3nc(Cl)ccc3n2)CC1,,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US20020016466A1,C[C@@H](C(=O)c1ccc(OCc2ccccc2)cc1)N1CCC(O)(c2ccccc2)CC1>>C[C@@H]([C@@H](O)c1ccc(OCc2ccccc2)cc1)N1CCC(O)(c2ccccc2)CC1,,CCO,,O,[BH4-].[Li+],val
US05843942,CCN(Cc1cc(Br)ccc1OCc1cccs1)c1ccc(C(=O)OC)cn1>>CCN(Cc1cc(Br)ccc1OCc1cccs1)c1ccc(C(=O)O)cn1,,CO,,[Na+].[OH-],,val
US20100121048A1,COC(=O)c1ncn(-c2ccccc2)c1C1CCCCC1>>O=C(O)c1ncn(-c2ccccc2)c1C1CCCCC1,,C1CCOC1,CO,[Na+].[OH-],,val
US04350697,CN1CCC2C(=O)c3ccccc3SC2C1.[Li]c1ccccc1>>CN1CCC2C(C1)Sc1ccccc1C2(O)c1ccccc1,,CCOCC,,O,,val
US20070093521A1,CC(C)(C)OC(=O)N1CCC(Nc2nc3cc(O)ccc3o2)CC1.CSCCCO>>CSCCCOc1ccc2oc(NC3CCN(C(=O)OC(C)(C)C)CC3)nc2c1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060194842A1,CC(C)(C)OC(=O)NCC1CCNCC1.COC(=O)C1(C=O)CCC1>>COC(=O)C1(CN2CCC(CNC(=O)OC(C)(C)C)CC2)CCC1,,C1CCOC1,,CC(=O)O,O=C([O-])O.[Na+],val
US20060089367A1,CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])c(NC(=O)COc3ccccc3)c2)CC1.FC(F)(F)Oc1ccc(CBr)cc1>>CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])c(N(Cc3ccc(OC(F)(F)F)cc3)C(=O)COc3ccccc3)c2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06017919,CCCCCOc1cc(-c2cccc(C=CC(=O)OC)c2)c(Br)c2ccccc12>>CCCCCOc1cc(-c2cccc(C=CC(=O)O)c2)c(Br)c2ccccc12,,CCO,,[Na+].[OH-],,val
US20160000929A1,C#CCCCC(=O)OCC(C)(COC(=O)CCCC#C)C(=O)O.CCCCB1O[C@@H]2C[C@H](O1)[C@H](C/C=C\CCCC(=O)OC(C)C)[C@H]2CC[C@@H](O)CCc1ccccc1>>C#CCCCC(=O)OCC(C)(COC(=O)CCCC#C)C(=O)O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)OC(C)C,CN(C)c1ccncc1,CO,ClCCl,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20090306066A1,CN(C)C(=O)[C@@H]1CCCN1C(=O)c1ccccc1>>CN(C)C[C@@H]1CCCN1Cc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06596730B1,COc1ccc(C(=O)O)cc1C(C)=O.Cc1cc(N)c2ncccc2n1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COc1ccc(NC(=O)Nc2cc(C)nc3cccnc23)cc1C(C)=O,,Cc1ccccc1,,CCN(CC)CC,,val
US04166735,CC(C)[O-].O=[N+]([O-])c1ccc(Cl)c(C(F)(F)F)c1>>CC(C)Oc1ccc([N+](=O)[O-])cc1C(F)(F)F,,CS(C)=O,,O,,val
US09006451B1,COc1cc(C(C)=O)cc(OC)c1OC.O=Cc1cccnc1Nc1ccccc1>>COc1cc(C(=O)C=Cc2cccnc2Nc2ccccc2)cc(OC)c1OC,,CO,,Cl,,val
US20050148624A1,NOCc1ccccc1.O=C(O)c1oc(=O)c2ccc(Cl)cc2c1-c1ccccc1>>O=C(O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1OCc1ccccc1,,CCO,,,,val
US20080319188A1,CN(C)C1CCNC1.O=C(Oc1ccccc1)N(C(=O)Oc1ccccc1)c1cc(Oc2ccc(NC(=O)C3(C(=O)Nc4ccccc4)CC3)c(F)c2)ccn1>>CN(C)[C@@H]1CCN(C(=O)Nc2cc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccccc5)CC4)c(F)c3)ccn2)C1,,CN(C)C=O,,,,val
US20120329818A1,C=CCC1(C(=O)O)CCN(C(=O)OC(C)(C)C)CC1.Nc1cccc(Cl)c1>>C=CCC1(C(=O)Nc2cccc(Cl)c2)CCN(C(=O)OC(C)(C)C)CC1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20050143421A1,CC(=O)NC[C@H]1CN(c2ccc(N3CCC(F)(CN=[N+]=[N-])CC3)c(F)c2)C(=O)O1>>CC(=O)NC[C@H]1CN(c2ccc(N3CCC(F)(CN)CC3)c(F)c2)C(=O)O1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US07547718B2,CCOCC(O)COCC.Cc1cccc([C@H](C)c2ncc[nH]2)c1C.O=C(Cl)Cl>>CCOCC(COCC)OC(=O)n1ccnc1[C@@H](C)c1cccc(C)c1C,,ClCCl,,c1ccncc1,O=C([O-])O.[Na+],val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccc(N5CCCC5)nc4)nc(Cl)c3n2)cc1.Nc1cc[nH]n1>>c1cc(Nc2nc(-c3ccc(N4CCCC4)nc3)nc3cn[nH]c23)n[nH]1,C1COCCO1,CO,,Cl,,val
US20100096327A1,C=Cc1ccc(CCl)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C=Cc1ccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1.[Cl-],,CC#N,,,,val
US20090324581A1,BrCc1ccccc1.CC(C)(C)OC(=O)n1ccc2cc(-c3ccc(O)cc3)ccc21>>CC(C)(C)OC(=O)N1CCc2cc(-c3ccc(OCc4ccccc4)cc3)ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050245741A1,CC(C)[Si](Oc1cc(O)c(NC(=O)C2CCCC2)cc1Cl)(C(C)C)C(C)C.O=[N+]([O-])c1cccc(S(=O)(=O)OC[C@@H]2CO2)c1>>CC(C)[Si](Oc1cc(OCC2CO2)c(NC(=O)C2CCCC2)cc1Cl)(C(C)C)C(C)C,,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150299179A1,CC(C)Oc1ccc(-c2nnc(-c3cccc4c3CCC[C@H]4N)s2)cc1C#N.COC(=O)CS(=O)(=O)Cl>>COC(=O)CS(=O)(=O)N[C@@H]1CCCc2c(-c3nnc(-c4ccc(OC(C)C)c(C#N)c4)s3)cccc21,,ClCCl,,Cl,,val
US04514416,CS(=O)(=O)Oc1ccc(C(=N)N)cc1C(=O)c1ccccc1.O=C(O)c1ccc(OCc2ccccc2)cc1>>N=C(N)c1ccc(OC(=O)c2ccc(OCc3ccccc3)cc2)c(C(=O)c2ccccc2)c1,,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130281366A1,CCOC(=O)COc1ccc(C(CC)=NOCc2ccc(C(F)(F)F)cc2)cc1>>CCC(=NOCc1ccc(C(F)(F)F)cc1)c1ccc(OCC(=O)O)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20100190775A1,COC(=O)c1nc(-c2cccc(N3C[C@@H]4CCCN4c4nc(SC)ncc4C3=O)c2)no1.N>>CSc1ncc2c(n1)N1CCC[C@H]1CN(c1cccc(-c3noc(C(N)=O)n3)c1)C2=O,,CO,,,,val
US20130172302A1,CCOC(=O)C(Br)c1ccccc1.NC(=O)C1CCNCC1>>CCOC(=O)C(c1ccccc1)N1CCC(C(N)=O)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20060148858A1,CC(C)(C)c1nn(-c2ccc(Br)cn2)cc1CCCO.COC(=O)Cc1cccc(OC)c1O>>COc1cccc(CC(=O)O)c1OCCCc1cn(-c2ccc(Br)cn2)nc1C(C)(C)C,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20090124663A1,Clc1ccc(N2CCC3(CC2)OCCO3)cc1Cl.NO>>ON=C1CCN(c2ccc(Cl)c(Cl)c2)CC1,,CO,,Cl,,val
US20160235734A1,Cc1ccc(S(=O)(=O)OCC2CCN(C(=O)OC(C)(C)C)CC2)cc1.O=C(O)C(O)(c1ccccc1)c1cccc(OCCCCC2OCCO2)c1>>CC(C)(C)OC(=O)N1CCC(COC(=O)C(O)(c2ccccc2)c2cccc(OCCCCC3OCCO3)c2)CC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20160221945A1,CC(C)(C)OC(=O)NCc1cc(-c2cnc(C(F)(F)F)nc2)ccc1C(=O)O.[NH4+]>>CC(C)(C)OC(=O)NCc1cc(-c2cnc(C(F)(F)F)nc2)ccc1C(N)=O,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04009175,CCNO.ClCc1nnc2n1-c1ccc(Br)cc1C(c1ccccn1)=NC2>>CCN(O)Cc1nnc2n1-c1ccc(Br)cc1C(c1ccccn1)=NC2,,CN(C)C=O,,[H-].[Na+],,val
US20090118357A1,COC(=O)c1ccc(N)cc1OC.NO>>COc1cc(N)ccc1C(=O)NO,,CO,,Cl,[K+].[OH-],val
US20100286118A1,CN1Cc2cc(-c3ccc(C[C@H](NC(=O)C4(NC(=O)OC(C)(C)C)CCOCC4)C(N)=O)cc3)ccc2C1=O>>CN1Cc2cc(-c3ccc(C[C@@H](C#N)NC(=O)C4(NC(=O)OC(C)(C)C)CCOCC4)cc3)ccc2C1=O,,ClCCl,,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US20110003815A1,CS(=O)(=O)OS(C)(=O)=O.O=C(NC1CCNCC1)c1ccc(C2(c3ccc(OCc4ccccn4)cc3)CC3CCC2C3)cc1>>CS(=O)(=O)N1CCC(NC(=O)c2ccc(C3(c4ccc(OCc5ccccn5)cc4)CC4CCC3C4)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US03937837,N#CCC(=O)c1ccc(O)cc1O.O=CCC(=O)OC(=O)CC=O>>CC(=O)O.N#Cc1coc2cc(O)ccc2c1=O,,c1ccncc1,,,,val
US20110046110A1,O=[N+]([O-])c1cccc2ccc(-c3cc(F)cc(C(F)(F)F)c3)nc12>>Nc1cccc2ccc(-c3cc(F)cc(C(F)(F)F)c3)nc12,[Fe],CC(C)O,O,[Cl-].[NH4+],,val
US20060189681A1,COc1ccc(CCC2(C3CCCC3)CC(=O)C(Cl)C(=O)O2)cc1Cl.Sc1nnc(-c2ccncc2)o1>>COc1ccc(CCC2(C3CCCC3)CC(O)=C(Sc3nnc(-c4ccncc4)o3)C(=O)O2)cc1Cl,,O,,,,val
US03989709,ClCCCNc1nc2ccccc2n1-c1ccc(Cl)cc1>>Clc1ccc(N2C3=NCCCN3c3ccccc32)cc1,,CO,,C[O-].[Na+],,val
US05854277,O=C(O)[C@@H]1CCC[C@H]1C(=O)O>>O=C1OC(=O)[C@H]2CCC[C@@H]12,,CC(=O)OC(C)=O,,,,val
US20080306068A1,CC(C)(C)OC(=O)Nc1ccc(OC2CCN(C(=O)c3c(Cl)cccc3Cl)CC2)cc1>>Nc1ccc(OC2CCN(C(=O)c3c(Cl)cccc3Cl)CC2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070112005A1,COC(=O)[C@@H]1CC[C@@H](c2nc(I)c3c(=O)[nH]c(N)nn23)CC1>>COC(=O)[C@@H]1CC[C@@H](c2nc(I)c3c(=O)[nH]cnn23)CC1,,C1CCOC1,CN(C)C=O,CC(C)(C)ON=O,,val
US06875884B1,Clc1ccc(CCNCCc2ccc(Cl)cc2)cc1.O=C(NCCCBr)Nc1ccccc1>>O=C(NCCCN(CCc1ccc(Cl)cc1)CCc1ccc(Cl)cc1)Nc1ccccc1,,CC#N,CN(C)C=O,[I-].[K+],,val
US20060041123A1,CC(C)(C)OC(=O)NC1CCN(CCc2c(Cl)cnc3ccc4c(c23)OCCO4)CC1>>NC1CCN(CCc2c(Cl)cnc3ccc4c(c23)OCCO4)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05650410,CCNCC.COc1ccc(-c2nc(CCBr)nc3cc(OC)c(OC)cc23)cc1OC>>CCN(CC)CCc1nc(-c2ccc(OC)c(OC)c2)c2cc(OC)c(OC)cc2n1,,O,,ClCCl,,val
US20020156054A1,CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(c2ccc(CC)cc2)=CCC3(C)C)cc1>>CCc1ccc(C2=CCC(C)(C)c3ccc(C#Cc4ccc(C(=O)O)cc4)cc32)cc1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20150166480A1,CCC(O)CN1CCC(COc2ccc(Br)cc2)CC1.COCCN(CCOC)S(F)(F)F>>CCC(F)CN1CCC(COc2ccc(Br)cc2)CC1,,ClCCl,,O=C([O-])O.[Na+],,val
US20090275618A1,C[C@@H](N)c1ccccc1.O=C1CC(c2cccc(OC(F)(F)F)c2)N(c2ccc(Br)cc2)C1=O>>C[C@@H](NC1=C[C@@H](c2cccc(OC(F)(F)F)c2)N(c2ccc(Br)cc2)C1=O)c1ccccc1,,ClCCl,,,,val
US20150291595A1,COc1ccc(S(=O)(=O)Nc2cccc(B3OC(C)(C)C(C)(C)O3)c2)cc1>>O=S(=O)(Nc1cccc(B(O)O)c1)c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,,val
US04435405,CN(C)C(=O)CCl.S=c1[nH]c2ccccc2cc1-c1ccccc1>>CN(C)C(=O)CSc1nc2ccccc2cc1-c1ccccc1,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US20040220191A1,CN(C)C1CCN(c2ccc(NC(=O)C3CCNCC3)cc2)C1.O=S(=O)(Cl)c1ccc(F)cc1>>CN(C)C1CCN(c2ccc(NC(=O)C3CCN(S(=O)(=O)c4ccc(F)cc4)CC3)cc2)C1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20160031857A1,COC(=O)C(=O)c1ccc2c(c1)CC(=O)N2>>COC(=O)Cc1ccc2c(c1)CC(=O)N2,[Pd],O=C(O)C(F)(F)F,,[H][H],,val
US20100261728A1,FC(F)(F)c1ccc(C2NCCc3ccccc32)cc1.O=C=Nc1cccnc1>>O=C(Nc1cccnc1)N1CCc2ccccc2C1c1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150291554A1,CC(C)(C)OC(=O)NN.O=C1CCN(C(=O)OCc2ccccc2)CC1>>CC(C)(C)OC(=O)NN=C1CCN(C(=O)OCc2ccccc2)CC1,,CCCCCCC,,,,val
US04607128,C=C(C)CO.FC(F)(F)c1ccc(Cl)cc1>>CC(C)=COc1ccc(C(F)(F)F)cc1,,O=S1(=O)CCCC1,,O,[K+].[OH-],val
US04786644,CCOC(=O)C1=C(O)c2ccccc2N(c2ccccc2)C1.Nc1nccs1>>O=C(Nc1nccs1)C1=C(O)c2ccccc2N(c2ccccc2)C1,,Cc1ccccc1,,,,val
US05120347,C#CCBr.CC(C)(C)n1[nH]c(C2=CCCC=C2)nc1=O>>C#CCn1c(-c2ccccc2)nn(C(C)(C)C)c1=O,,Cc1ccccc1,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20050234101A1,C#Cc1ncc(C2=CCC(C)CC2)cc1F.CC1CCN(CCOc2ccc(I)cc2)CC1>>CC1CC=C(c2cnc(C#Cc3ccc(OCCN4CCC(C)CC4)cc3)c(F)c2)CC1,,CCN(CC)CC,,,,val
US20130102576A1,COC(=O)Cn1ccc2cc(N(C(=O)OC(C)(C)C)S(C)(=O)=O)ccc21>>CC(C)(C)OC(=O)N(c1ccc2c(ccn2CC(=O)O)c1)S(C)(=O)=O,,O,,C1CCOC1,[Li+].[OH-],val
US20090118284A1,O=[N+]([O-])c1ccc2c(c1)c(-c1cc3cnccc3o1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1>>Nc1ccc2c(c1)c(-c1cc3cnccc3o1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1,[Pd],CCOC(C)=O,CO,,,val
US04125732,COC(=O)Cc1ccc(O)cc1.ClCCCBr>>COC(=O)Cc1ccc(OCCCCl)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05137881,BrCc1ccccc1.CC(C)c1nc2c(c(-c3ccc(F)cc3)c1C=O)COC(=O)N2>>CC(C)c1nc2c(c(-c3ccc(F)cc3)c1C=O)COC(=O)N2Cc1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US20150291632A1,C=[N+]=[N-].O=C(Cc1ccc(Cl)cc1F)c1ccc(Oc2ccc(Cl)cc2)cn1>>Fc1cc(Cl)ccc1CC1(c2ccc(Oc3ccc(Cl)cc3)cn2)CO1,,CCOCC,,,,val
US20040171881A1,CCCCn1cc(C(C)=O)c2ccc(C(=O)O)cc21.CCc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1>>CCCCn1cc(C(C)=O)c2ccc(C(=O)N[C@@H](Cc3cc(F)cc(F)c3)[C@H](O)CNCc3cccc(CC)c3)cc21,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US04523042,CC(=O)Cl.CC(C=CC1=C(C)CCCC1(C)C)=CC=CC(C)=CC=C(C)CO>>CC(=O)OCC(C)=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C,,CCOCC,ClCCl,c1ccncc1,,val
US20110275611A1,CNc1nc(Cl)cc(N2CCC[C@H]2C(F)(F)F)n1.N#Cc1c(F)cc(B(O)O)cc1F>>CNc1nc(-c2cc(F)c(C#N)c(F)c2)cc(N2CCC[C@H]2C(F)(F)F)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])O.[Na+],,val
US20120094979A1,CC(C)Oc1ccc(-c2nccs2)cc1C#N.O=C1CCC(=O)N1Br>>CC(C)Oc1ccc(-c2ncc(Br)s2)cc1C#N,,O,,CN(C)C=O,,val
US05446152,BrCC1CCCCC1.CCN(CC)CCN1Cc2cc(Cl)ccc2NC1=O>>CCN(CC)CCN1CN(CC2CCCCC2)c2ccc(Cl)cc2C1=O,,CC(=O)N(C)C,,O,[H-].[Na+],val
US20090082367A1,CC(C)(c1cccs1)c1nnc(C2CC2)n1C1CC1.O=C1CCC(=O)N1Br>>CC(C)(c1ccc(Br)s1)c1nnc(C2CC2)n1C1CC1,,CC(=O)O,,,,val
US20060167251A1,O=[N+]([O-])c1ccc(Cl)cc1F.Sc1ccccc1>>O=[N+]([O-])c1ccc(Cl)cc1Sc1ccccc1,,CN(C)C=O,,CCN(CC)CC,O,val
US20080051415A1,CC(C)O.Oc1ccc2nc(Cl)sc2c1>>CC(C)Oc1ccc2nc(Cl)sc2c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090176786A1,Nc1ccc(SSc2ccc(N)cc2)cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1ccc(SSc2ccc(NC(=O)C(F)(F)F)cc2)cc1)C(F)(F)F,,CCN(CC)CC,,ClC(Cl)Cl,,val
US20070155721A1,CCOC(=O)c1cc2c(O)cccc2[nH]1.OCc1ccoc1>>CCOC(=O)c1cc2c(OCc3ccoc3)cccc2[nH]1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160090374A1,CC(=O)N[C@H]1CCNC1.Clc1nc(Cl)c2ncccc2n1>>CC(=O)N[C@H]1CCN(c2nc(Cl)nc3cccnc23)C1,,CCO,ClC(Cl)Cl,,,val
US20100105900A1,CCCCCCCOc1ccc(N=C=O)cc1.C[N+](C)(C)C[C@H](N)CC(=O)[O-]>>CCCCCCCOc1ccc(NC(=O)N[C@H](CC(=O)[O-])C[N+](C)(C)C)cc1,,CO,,CCN(C(C)C)C(C)C,,val
US20100069352A1,CC(=O)Cl.COc1cc(-n2ccc3nc(-c4ccc(Cl)cc4)sc3c2=O)ccc1OC1CNC1>>COc1cc(-n2ccc3nc(-c4ccc(Cl)cc4)sc3c2=O)ccc1OC1CN(C(C)=O)C1,,ClCCl,,CCN(CC)CC,Cl,val
US04908363,CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O.Cc1nccn1N>>Cc1nccn1N=Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,,CCO,,Cl,,val
US05252732,CC(C)OC(=N)C(Cl)(Cl)Cl.CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(O)C3)C(C)C(O)CC1=O)C(C)CC2OC>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OC(C)C)C3)C(C)C(O)CC1=O)C(C)CC2OC,,CCOC(C)=O,,O=S(=O)(O)C(F)(F)F,,val
US04555503,NC(=O)CCl.NCCCC[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N1CCC[C@H]1C(=O)O>>NC(=O)CNCCCC[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N1CCC[C@H]1C(=O)O,,CCO,O,CCN(CC)CC,,val
US20110015196A1,BrCc1ccccc1.CC(C)(C)OC(=O)[C@H]1C[C@@H](C(=O)O)C1(C)C>>CC(C)(C)OC(=O)[C@H]1C[C@@H](C(=O)OCc2ccccc2)C1(C)C,,CCOC(C)=O,CN(C)C=O,,,val
US07074801B1,C=C[Sn](CCCC)(CCCC)CCCC.Nc1ccc(Br)cn1>>C=Cc1ccc(N)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1C,,,,val
US20160083376A1,CCOC(=O)c1c(Cl)c(-c2cccc([N+](=O)[O-])c2)nn(C)c1=O.CN>>CCOC(=O)c1c(NC)c(-c2cccc([N+](=O)[O-])c2)nn(C)c1=O,,ClCCl,,CCO,,val
US20150295186A1,c1ccc2nc3ccccc3nc2c1>>c1ccc2c(c1)Nc1ccccc1N2,,CCO,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US06458814B1,CCOC(=O)CC(Cc1nc(C(=O)NCCCCNc2ccccn2)co1)c1ccccc1>>O=C(O)CC(Cc1nc(C(=O)NCCCCNc2ccccn2)co1)c1ccccc1,,C1CCOC1,O,[Li+].[OH-],,val
US20130237501A1,CCOC(=O)c1c(-c2ccc(Cl)cc2)oc2ccc(OC(C)C)cc12.O=[N+]([O-])O>>CCOC(=O)c1c(-c2ccc(Cl)cc2)oc2cc([N+](=O)[O-])c(OC(C)C)cc12,,ClC(Cl)Cl,O,,,val
US05616599,CCCc1nc(C(O)CCC)c(C(N)=O)n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCc1nc(C(O)CCC)c(C(N)=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,C1COCCO1,,Cl,,val
US04180522,CN(C)CCCl.Nc1ccc(Cl)c(Cl)c1>>CN(C)CCNc1ccc(Cl)c(Cl)c1,,Cc1ccccc1,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20120208819A1,Nc1ccc(F)cc1N.O=C(O)c1cc(C(F)(F)F)cnc1Cl>>Nc1ccc(F)cc1NC(=O)c1cc(C(F)(F)F)cnc1Cl,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05952355,CI.O=Cc1c[nH]c2ccc([N+](=O)[O-])cc12>>Cn1cc(C=O)c2cc([N+](=O)[O-])ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100311748A1,Cc1ccc(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCC2CCCCN2C(=O)OC(C)(C)C)cc1>>Cc1ccc(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCC2CCCCN2)cc1,,CO,,Cl,,val
US20020137968A1,CC1(C)C=CC(=O)C1.NCc1ccccc1>>CC1(C)CCC(NCc2ccccc2)C1,O=[Pt],CCO,,C,,val
US20160068559A1,CC(C)I.CC1(C)O[C@@H]2[C@H](O1)[C@@H](CNCCCN1C(=O)c3ccccc3C1=O)O[C@H]2n1cnc2c(N)ncnc21>>CC(C)N(CCCN1C(=O)c2ccccc2C1=O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US06133457,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.Cc1ccc(S(=O)(=O)OC[C@H](O)[C@H](C)CCc2ccccc2)cc1>>Cc1ccc(S(=O)(=O)OC[C@H](O[Si](C)(C)C(C)(C)C)[C@H](C)CCc2ccccc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20160115126A1,Cc1c[nH]c2c(C(N)=O)ccc(C3=CCCNC3)c12>>Cc1c[nH]c2c(C(N)=O)ccc(C3CCCNC3)c12,[Pd],CO,,,,val
US06627651B1,COC(=O)C1=Cc2cc(OC3CCN(C(=O)OC(C)(C)C)CC3)ccc2CCC1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc3c(c2)C=C(C(=O)O)CCC3)CC1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20120277305A1,CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C>>CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)NCCCO,,ClCCl,,On1nnc2ccccc21,,val
US20080221220A1,COC(=O)c1ccc(Br)cc1.OB(O)c1ccc(Cl)cc1Cl>>COC(=O)c1ccc(-c2ccc(Cl)cc2Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US05086055,CN1CC(CCCl)OC1=O.Fc1cccc(N2CCNCC2)c1>>CN1CC(CCN2CCN(c3cccc(F)c3)CC2)OC1=O,,CCCCO,,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20050267075A1,CC(C)(C)OC(=O)N[C@@H](CSCCOP(=O)(N(CCCl)CCCl)N(CCCl)CCCl)C(=O)O.CO>>COC(=O)[C@@H](N)CSCCOP(=O)(N(CCCl)CCCl)N(CCCl)CCCl,,CCOC(C)=O,ClCCl,C[Si](C)(C)Cl,,val
US05631373,Cc1cc(F)c([N+](=O)[O-])cc1F.NCC(=O)[O-].[Na+]>>Cc1cc(NCC(=O)[O-])c([N+](=O)[O-])cc1F.[Na+],,CN(C)C=O,O,,,val
US20020052369A1,C1CCNC1.O=C1Cc2cc(S(=O)(=O)Cl)ccc2N1>>O=C1Cc2cc(S(=O)(=O)N3CCCC3)ccc2N1,,CCOC(C)=O,ClCCl,Cl,c1ccncc1,val
US20090029975A1,CCOC(=O)CCc1cc(S(C)(=O)=O)cc(C#N)n1.COC(=O)c1ccc(Cl)cc1S>>CCOC(=O)CCc1cc(S(C)(=O)=O)cc(-c2nc(=O)c3ccc(Cl)cc3s2)n1,,Cc1ccccc1,,CCN(CC)CC,,val
US20090137577A1,C[C@@H]1CN(Cc2ccc(O)c(F)c2)C(=O)O1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>C[C@@H]1CN(Cc2ccc(OS(=O)(=O)C(F)(F)F)c(F)c2)C(=O)O1,,C1CCOC1,,CC(C)NC(C)C,,val
US20160186094A1,CCCCCCCCCCCC(C)c1ccccc1.COCBr>>CCCCCCCCCCCC(C)c1ccc(CBr)cc1,,O,,O=S(=O)(O)O,,val
US20150152108A1,COc1cc(-c2cccc(C(F)(F)F)c2)nc2c1N1CC[C@@H](C1)N2C(=O)Nc1ccccn1>>O=C(Nc1ccccn1)N1c2nc(-c3cccc(C(F)(F)F)c3)cc(O)c2N2CC[C@H]1C2,,ClCCl,ClCCl,BrB(Br)Br,O=C([O-])O.[Na+],val
US20120010185A1,BrP(Br)Br.O=C(Cn1ccc(OCc2ccccc2)cc1=O)c1ccc(CO)cc1>>O=C(CBr)c1ccc(CO)cc1,,C1CCOC1,ClCCl,,,val
US04178379,CCCNN.O=C1C(=Cc2ccccc2)COCC1=Cc1ccccc1>>CCCn1nc2c(c1-c1ccccc1)COCC2=Cc1ccccc1,,CO,,,,val
US20130237525A1,CCOc1ccccc1B(O)O.O=C1CCC=C(OP(=O)(Oc2ccccc2)Oc2ccccc2)N1Cc1ccc(OC(F)(F)F)cc1>>CCOc1ccccc1C1=CCCC(=O)N1Cc1ccc(OC(F)(F)F)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20040157836A1,CC(C)(C)OC(=O)Nc1ccc2ccccc2c1C(=O)O>>Nc1ccc2c(c1C(=O)O)CCCC2,,CC(=O)O,,,,val
US04064106,CCCCCCCCCCCCCCCCCCBr.S=P(S)(C1CCCCC1)C1CCCCC1>>CCCCCCCCCCCCCCCCCCSP(=S)(C1CCCCC1)C1CCCCC1,,CC(C)=O,,,,val
US20150218124A1,CC(C)Oc1cc(C#N)c(Br)c(C#N)c1OC(C)C.FC(F)(F)c1ccc(S)cc1>>CC(C)Oc1cc(C#N)c(Sc2ccc(C(F)(F)F)cc2)c(C#N)c1OC(C)C,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05106878,CCN(CC)CCCCCCO.O=Cc1ccc(O)cc1>>CCN(CC)CCCCCCOc1ccc(C=O)cc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04579947,Cl.Cl.NCCCN1CCN(Cc2ccc(Cl)cc2)CC1.O=C=NCc1ccccc1>>Cl.Cl.O=C(NCCCN1CCN(Cc2ccc(Cl)cc2)CC1)NCc1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US20130059853A1,COc1ccc(-c2ccc3c(c2)COC3=O)c(OC)c1O.CS(=O)(=O)c1ccc(CBr)cc1>>COc1ccc(-c2ccc3c(c2)COC3=O)c(OC)c1OCc1ccc(S(C)(=O)=O)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160128989A1,FC(F)c1cc(Cl)nc2c1c(I)nn2C1CCCCO1.OB(O)c1ccccc1>>FC(F)c1cc(Cl)nc2c1c(-c1ccccc1)nn2C1CCCCO1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20030236297A1,C[C@H](CCc1ccc(C#CCCCc2ccccc2)s1)C(N)O.O=C(O)C(=O)O>>C[C@H](CCc1ccc(C#CCCCc2ccccc2)s1)C(N)O.O=C(O)C(=O)O,,CO,,,,val
US05393732,C#CCO.Ic1ncn(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>OCC#Cc1ncn(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,CCN(CC)CC,O,val
US20100298301A1,NC(=O)c1nc(-c2c(F)cccc2F)oc1-c1ccc(O)cc1.O=C(OCc1ccccc1)N1CCC(CBr)CC1>>NC(=O)c1nc(-c2c(F)cccc2F)oc1-c1ccc(OCC2CCNCC2)cc1,[Pd],CO,,,,val
US20110152285A1,CC(=O)N1CCc2c(F)cccc21.O=[N+]([O-])O>>CC(=O)N1CCc2c1ccc([N+](=O)[O-])c2F,,O=S(=O)(O)O,,O=C([O-])O.[Na+],,val
US20090192176A1,CCCC[Sn](CCCC)(CCCC)C1=CCOCC1.Clc1nc(Cl)c2cnn(C3CCCCO3)c2n1>>Clc1nc(C2=CCOCC2)c2cnn(C3CCCCO3)c2n1,,CN(C)C=O,,,,val
US20140155419A1,Cc1ccc(C(NC(=O)Cc2ccc(C(=O)Cc3cccnc3C)cc2)c2ccccc2)c(C)c1>>Cc1ccc(C(NC(=O)Cc2ccc(C(O)Cc3cccnc3C)cc2)c2ccccc2)c(C)c1,,CO,O,[BH4-].[Na+],,val
US04995903,CC(C)=CCN.CN(N=O)C(=N)N[N+](=O)[O-]>>CC(C)=CCNC(=N)N[N+](=O)[O-],,CCO,O,,,val
US20050222175A1,CC(C)(C)OC(=O)N1CCC(Nc2ncnc3sccc23)CC1.O=C1CCC(=O)N1Cl>>CC(C)(C)OC(=O)N1CCC(Nc2ncnc3sc(Cl)cc23)CC1,,CC(=O)O,,,,val
US20060155121A1,C=O.Cc1cc(NCc2ccc(C(F)(F)F)cc2)cc(C)c1NC(=O)CC1CCCC1>>Cc1cc(N(C)Cc2ccc(C(F)(F)F)cc2)cc(C)c1NC(=O)CC1CCCC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20120258953A1,CC(C)(C)OC(=O)N1CCCCC1=O.Fc1cc([Mg]Br)cc(F)c1F>>CC(C)(C)OC(=O)NCCCCC(=O)c1cc(F)c(F)c(F)c1,,C1CCOC1,,Cl,,val
US20040198982A1,COc1ccc(COC(=O)[C@H](CC(C)C)Nc2nn(C(=O)OC(C)(C)C)cc2-c2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2)cc1>>CC(C)C[C@H](Nc1nn(C(=O)OC(C)(C)C)cc1-c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)cc1)C(=O)O,[Pd],CCO,,,,val
US20130289058A1,COC(=O)CC12CCC(c3ccc(B4OC(C)(C)C(C)(C)O4)cc3)(CC1)CO2.Nc1ccc(Br)nc1>>COC(=O)CC12CCC(c3ccc(-c4ccc(N)cn4)cc3)(CC1)CO2,,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20110092497A1,Brc1cnc(Nc2ccc(-n3cc(-c4ccccn4)nn3)cc2)c2nccn12.NC(=O)c1ccc(B(O)O)cc1>>NC(=O)c1ccc(-c2cnc(Nc3ccc(-n4cc(-c5ccccn5)nn4)cc3)c3nccn23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CN(C)C=O,,,val
US05021420,Fc1ccc(N2CCNCC2)cc1.O=S1(=O)c2cccc3cccc(c23)N1CCCCl>>O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccc(F)cc2)CC1,,Cc1ccccc1,,CCN(CC)CC,,val
US06506792B1,O=c1c(-c2ccc(O)cc2)coc2cc(O)ccc12>>Oc1ccc(C2COc3cc(O)ccc3C2)cc1,[Pd],CC(=O)O,,O=O,,val
US05760032,CCOC(=O)CC1N=C(c2ccccc2Cl)c2cc(CC)sc2-n2c(CNC(=O)c3ccc(Cl)c(Cl)c3)nnc21.CO>>CC(C)[O-].CCc1cc2c(s1)-n1c(CNC(=O)c3ccc(Cl)c(Cl)c3)nnc1C(CC(=O)O)N=C2c1ccccc1Cl,,CO,,[Na+].[OH-],,val
US20140349972A1,Br[Mg]c1ccccc1.CC(C)(C)[S@@](=O)/N=C/c1ccc(Br)cc1>>CC(C)(C)[S@](=O)N[C@H](c1ccccc1)c1ccc(Br)cc1,,C1CCOC1,,,,val
US20110319392A1,CCOC(=O)c1cccc(NS(=O)(=O)c2ccccc2)c1.Cc1ccnc(Cl)n1>>O=C(Cc1ccnc(Cl)n1)c1cccc(NS(=O)(=O)c2ccccc2)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120184546A1,N=C(N)NN.O=c1oc(Cc2ccc([N+](=O)[O-])cc2)nc2ccccc12>>Nc1nc2c3ccccc3nc(Cc3ccc([N+](=O)[O-])cc3)n2n1,,CCOC(C)=O,c1ccncc1,O=C(O)O,,val
US04886809,CCC(=O)NC1CCN(c2ccc(N)cc2)CC1.O=C(Cl)CCBr>>CCC(=O)NC1CCN(c2ccc(NC(=O)CCBr)cc2)CC1,,Cc1ccccc1,,CCN(CC)CC,,val
US20110251190A1,NC1=N[C@@]2(CS1)c1cc(I)ccc1Oc1ncc(Br)cc12.OB(O)c1cnccc1F>>NC1=N[C@@]2(CS1)c1cc(-c3cnccc3F)ccc1Oc1ncc(Br)cc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)C(C)C2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3c(=O)[nH][nH]c3c2)cc1.Cl>>Cc1cc(C(=O)NC2CCNC(C)C2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc3c(=O)[nH][nH]c3c2)cc1.Cl,,C1COCCO1,,,,val
US20090181942A1,COc1cccc([C@H]2S[C@H](CC(=O)Nc3ccc(CCC(=O)OC(C)(C)C)cn3)c3nnc(C(F)(F)F)n3-c3ccc(Cl)cc32)c1OC>>COc1cccc([C@H]2S[C@H](CC(=O)Nc3ccc(CCC(=O)O)cn3)c3nnc(C(F)(F)F)n3-c3ccc(Cl)cc32)c1OC,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100210466A1,COC(=O)COC(C)(C)C#Cc1cc(-c2ccc(Cl)cc2)ccc1C>>Cc1ccc(-c2ccc(Cl)cc2)cc1C#CC(C)(C)OCC(=O)O,,C1COCCO1,O,[K+].[OH-],,val
US05162311,CCOC(=O)C(N)Cc1cc(CP(=O)(O)O)cc(-c2ccccc2)c1>>NC(Cc1cc(CP(=O)(O)O)cc(-c2ccccc2)c1)C(=O)O,,Cl,,,,val
US20080113978A1,CCC(CC)c1cc(C)nn2c(B(O)O)c(C)nc12.Cc1nc(C)c(Br)s1>>CCC(CC)c1cc(C)nn2c(-c3sc(C)nc3C)c(C)nc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20070249670A1,Nc1cc(-c2ccc(OC(F)(F)F)cc2)sc1C(=O)O.O=C=Nc1c(Cl)cccc1Cl>>O=C(Nc1cc(-c2ccc(OC(F)(F)F)cc2)sc1C(=O)O)Nc1c(Cl)cccc1Cl,,CN(C)C=O,,CCN(CC)CC,O,val
US08304419B2,CNS(=O)(=O)c1nc(Cl)c(CO)n1COCC[Si](C)(C)C>>CNS(=O)(=O)c1nc(Cl)c(C=O)n1COCC[Si](C)(C)C,O=[Mn]=O,ClCCl,,,,val
US20120316156A1,COC(=O)[C@@H]1CCC[C@@H]1N(Cc1ccc(F)cc1)C(=O)CC1=NS(=O)(=O)c2cc(NS(C)(=O)=O)ccc2N1>>CS(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(C1=C(O)[C@@H]3CCC[C@@H]3N(Cc3ccc(F)cc3)C1=O)N2,,CCO,,C,C[O-].[Na+],val
US06333336B1,BrBr.Cc1cc(=O)c(C(=O)O)c[nH]1>>Cc1[nH]cc(C(=O)O)c(=O)c1Br,,CC(=O)O,,c1ccncc1,,val
US20120028919A1,O=[N+]([O-])c1ccc2nc(CO)[nH]c2c1>>Nc1ccc2nc(CO)[nH]c2c1,[Pd],CO,,Cl,,val
US20140163026A1,CCCC[Sn](CCCC)(CCCC)c1cnc(C)s1.COC(=O)Cc1ccc(Br)nc1>>COC(=O)Cc1ccc(-c2cnc(C)s2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20080039517A1,Cc1ccccc1CN(c1ccc(C#N)c(Cl)c1)[C@H]1CC(=O)N(CC(O)CO)C1>>Cc1ccccc1CN(c1ccc(C#N)c(Cl)c1)[C@H]1CC(=O)N(CC=O)C1,,C1CCOC1,,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20120110702A1,CCOC(=O)C1(CO)CC1.CS(=O)(=O)Cl>>CCOC(=O)C1(COS(C)(=O)=O)CC1,,ClCCl,O,CCN(CC)CC,,val
US05002949,Cc1nc(O)c(Br)c(Cl)n1.N#Cc1cncc(CN)c1>>Cc1nc(=O)c(Br)c(NCc2cncc(C#N)c2)[nH]1,,COCCOC,,Cc1cccc(C)n1,,val
US20040180896A1,CC(C)(C)C(=O)CC(=O)C(C)(C)C.CC(C)Cn1ncc2cc(Br)ccc21.O=C(O)c1ccccc1O>>CC(C)Cn1ncc2cc(Oc3ccccc3CC(=O)O)ccc21,Cl[Cu],CN1CCCC1=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040092582A1,NO.O=Cc1ccc2c(c1)CCO2>>N#Cc1ccc2c(c1)CCO2,,O=CO,,Cl,[K+].[OH-],val
US20020103192A1,CCO.N#CC(O)CCCCCCOc1ccc(-c2ccccc2)cc1>>OC(CCCCCCOc1ccc(-c2ccccc2)cc1)C1=NCCO1,,CCO,ClC(Cl)Cl,CC(=O)Cl,,val
US20020103377A1,O=C(Cl)COCc1ccccc1.OC1CCNC1>>O=C(COCc1ccccc1)N1CCC(O)C1,,ClCCl,,CCN(CC)CC,O,val
US20160009683A1,CCOC(=O)C(F)(F)c1ccc(-c2ccc(F)cc2)cc1>>O=C(O)C(F)(F)c1ccc(-c2ccc(F)cc2)cc1,,C1CCOC1,O,CO,[Li+].[OH-],val
US05166347,CC(C)OC(=NC#N)c1cccnc1.NCCc1ccccc1>>N#CNC(=NCCc1ccccc1)c1cccnc1,,CO,,,,val
US20070197531A1,CC(C)(C)OC(=O)N1CCC(F)(C(=O)c2ccc(F)cc2)CC1>>O=C(c1ccc(F)cc1)C1(F)CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20040014971A1,CCCC[Sn](CCCC)(CCCC)c1ccco1.COC(=O)C(c1ccccc1)N1CCN(c2ccc(NC(=O)c3ccccc3I)cc2)CC1>>COC(=O)C(c1ccccc1)N1CCN(c2ccc(NC(=O)c3ccccc3-c3ccco3)cc2)CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US06610692B1,CCOC(=O)Cn1c(C)cc(-c2ccccc2C(C)C)c(OC(C)=O)c1=O>>Cc1cc(-c2ccccc2C(C)C)c(O)c(=O)n1CC(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20120035163A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C(N)=O)[nH]c12>>Cc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C(N)=S)[nH]c12,,C1CCOC1,,,,val
US05536725,Clc1ccccc1C=C1CCC2(CC1)OCCO2>>Clc1ccccc1CC1CCC2(CC1)OCCO2,[Pd],CCO,,,,val
US04988694,BrBr.CC(=O)c1ccc(N)c(Cl)n1>>CC(=O)c1cc(Br)c(N)c(Cl)n1,,CC(=O)O,,,,val
US07622466B2,C1COCCN1.CC(C)(C)OC(=O)n1c(C(=O)O)cc2cc(OCc3ccccc3)cnc21>>CC(C)(C)OC(=O)n1c(C(=O)N2CCOCC2)cc2cc(OCc3ccccc3)cnc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20050070583A1,CCOC(=O)CBr.CCc1ccccc1O.O=S(=O)(O)Cl>>CCOC(=O)COc1ccc(S(=O)(=O)Cl)cc1CC,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US09085570B2,COC(=O)c1ccc(-c2nc(CS(=O)(=O)c3ccc(C)cc3C)c(C)o2)cc1>>Cc1ccc(S(=O)(=O)Cc2nc(-c3ccc(C(=O)O)cc3)oc2C)c(C)c1,,C1COCCO1,,[Na+].[OH-],,val
US20090281075A1,OCc1cc(Br)ccc1Cl.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>[N-]=[N+]=NCc1cc(Br)ccc1Cl,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,,val
US20080021022A1,CS(=O)(=O)N1Cc2ccccc2C12CCNCC2.Cc1ccc(-c2oncc2C(=O)Cl)cc1>>Cc1ccc(-c2oncc2C(=O)N2CCC3(CC2)c2ccccc2CN3S(C)(=O)=O)cc1,,ClCCl,,,,val
US20110224155A1,CC(C)(C)OC(=O)N1CCC(CCO)CC1.N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)N1CCC(CCOc2cccc([N+](=O)[O-])c2C#N)CC1,,CN(C)C=O,,[H-].[Na+],,val
US06100272,CC(=O)N1CCc2cc(Br)c(OCC3=CCN(C)CC3)cc21>>CC(=O)N1CCc2cc3c(cc21)OCC31CCN(C)CC1,,c1ccccc1,,Cc1ccccc1,,val
US20140094445A1,COC(=O)c1cncc(Cl)c1.NN>>NNC(=O)c1cncc(Cl)c1,,CO,,,,val
US20100197652A1,COC(=O)c1cc(-c2cncc(C)c2)cnc1Cl.OB(O)c1ccccc1F>>COC(=O)c1cc(-c2cncc(C)c2)cnc1-c1ccccc1F,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090318690A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.COCOc1cc(OCC2CC2)c(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cc1Br>>C=C(OCC)c1cc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c(OCC2CC2)cc1OCOC,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,O,CN1CCCC1=O,,val
US20130338140A1,CN(C[C@@H](N)c1ccc(C(F)(F)F)c(F)c1)C(=O)OC(C)(C)C.C[C@@H](CO)Nc1ncc2c(n1)CNCC2.O=C(n1ccnc1)n1ccnc1>>C[C@@H](CO)Nc1ncc2c(n1)CN(C(=O)N[C@H](CN(C)C(=O)OC(C)(C)C)c1ccc(C(F)(F)F)c(F)c1)CC2,,O,,ClCCl,,val
US20090264445A1,CC(C)(O)Cn1ccc(NC(=O)[C@H](CC2CCCCC2)N2CC(Oc3c(F)ccc(Cl)c3F)=CC2=O)n1.O=C(O)[C@H](CC1CCCCC1)N1CC(Oc2ccccc2C(F)(F)F)=CC1=O>>COCCn1ccc(NC(=O)[C@H](CC2CCCCC2)N2CC(Oc3ccccc3C(F)(F)F)=CC2=O)n1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20150045349A1,CC(C1CC1)n1cc(Br)c2[nH]nc(N)c2c1=O>>C[C@@H](C1CC1)n1cc(Br)c2[nH]nc(N)c2c1=O,,CCCCCC,CCO,,,val
US05750555,COC(=O)[C@H](C)NC(=O)CCn1cc(C2=C(c3cn(C)c4ccccc34)C(=O)NC2=O)c2ccccc21>>C[C@H](NC(=O)CCn1cc(C2=C(c3cn(C)c4ccccc34)C(=O)NC2=O)c2ccccc21)C(=O)O,,C1COCCO1,O,[Li+].[OH-],,val
US04655816,CCOC(=O)/C(C(=O)CC)=C(\N)C(F)(F)F.CCOC(=O)C(F)(F)Cl>>CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)Cl)c(C)c1O,,CCOCC,,CC(C)NC(C)C,[Li]CCCC,val
US20080181866A1,CC(C)(C)OC(=O)N1[C@H](C(=O)Nc2nc(-c3ccc(C(=O)NC4CC4)cc3)cs2)CC[C@@H]1c1ccccc1>>O=C(NC1CC1)c1ccc(-c2csc(NC(=O)[C@@H]3CC[C@H](c4ccccc4)N3)n2)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100076029A1,CC(=O)N(C)CC(C)(C)c1cc(NC(=O)OC(C)(C)C)on1>>CC(=O)N(C)CC(C)(C)c1cc(N)on1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160002263A1,C=CCCO.C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OCC)c(C)nc3cc(-c4ncc(Cc5ccccc5O)s4)nn23)CC1>>C=CCCOc1ccccc1Cc1cnc(-c2cc3nc(C)c([C@H](OC(C)(C)C)C(=O)OCC)c(N4CCC(C)(OCC=C)CC4)n3n2)s1,,C1CCOC1,O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140213574A1,CC(C)(C)OC(=O)Nc1cccc(Oc2nc(S(C)(=O)=O)ncc2C(=O)Nc2ccccc2)c1.CO>>COc1cccc(N)c1,[Pd],CO,,,,val
US20050272777A1,CC(C)(C)c1ccc(-c2cc(Cl)ncn2)cc1.Oc1ccc2[nH]ccc2c1>>CC(C)(C)c1ccc(-c2cc(Oc3ccc4[nH]ccc4c3)ncn2)cc1,,C1COCCO1,,[Na+].[OH-],,val
US20140187532A1,O=C(c1ccccc1)N1CCC(c2ccc(OCc3ccccc3)cc2OCc2ccccc2)CC1>>O=C(c1ccccc1)N1CCC(c2ccc(O)cc2O)CC1,[Pd],CO,,,,val
US20100323994A1,N[C@H]1CC[C@H](N)CC1.O=C(Nc1ccncc1)c1cnc2c(Nc3ccncn3)cc(Cl)nn12>>N[C@@H]1CC[C@@H](Nc2cc(Nc3ccncn3)c3ncc(C(=O)Nc4ccncc4)n3n2)CC1,,CN1CCCC1=O,CO,,,val
US20050014804A1,CC(C)C1CC1(CNC(=O)OC(C)(C)C)C(=N)NO.O=C(c1ncc[nH]1)c1ncc[nH]1>>CC(C)C1CC1(CNC(=O)OC(C)(C)C)c1noc(=O)[nH]1,,C1CCOC1,,,,val
US05998438,CCCC[Sn](CCCC)(CCCC)C1C=COCC1.CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(Br)cc12>>CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(C3C=COCC3)cc12,,Cc1ccccc1,,,,val
US20020016329A1,CCI.COC(=O)c1cccc(Nc2nc(Cl)nc3[nH]cnc23)c1>>CCn1cnc2c(Nc3cccc(C(=O)OC)c3)nc(Cl)nc21,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20060094767A1,CC(C)(C)OC(=O)N1CCC(n2c(=O)n(CC3(C)Cn4cc([N+](=O)[O-])nc4O3)c3ccccc32)CC1>>CC1(Cn2c(=O)n(C3CCNCC3)c3ccccc32)Cn2cc([N+](=O)[O-])nc2O1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040248941A1,CC(Cl)OC(=O)Cl.OCC1COCO1>>CC(Cl)OC(=O)OC1COCOC1,,C1CCOC1,,c1ccncc1,,val
US20080096903A1,NS(=O)(=O)Cl.Nc1nc(F)nc2c1nc(Cc1cc3c(cc1I)OCO3)n2Cc1cn(CCO)nn1>>Nc1nc(F)nc2c1nc(Cc1cc3c(cc1I)OCO3)n2Cc1cn(CCOS(N)(=O)=O)nn1,,CC(=O)N(C)C,,CCN(CC)CC,O,val
US20080139631A1,Cn1ncc(C(=O)O)c1C(F)(F)F.[H]/N=C(/Cn1c(CCC)cc2c(Cl)c(C#N)ccc21)NO>>CCCc1cc2c(Cl)c(C#N)ccc2n1Cc1noc(-c2cnn(C)c2C(F)(F)F)n1,,C1CCOC1,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20150232435A1,NCCCCN1CCN(c2ccc3ccccc3n2)CC1.O=C(O)c1cn2cccnc2n1>>O=C(NCCCCN1CCN(c2ccc3ccccc3n2)CC1)c1cn2cccnc2n1,,CO,ClC(Cl)Cl,,,val
US20070197534A1,CN(C)CCNc1nc2cc(F)ccc2[n+]([O-])n1.COCCO>>COCCOc1ccc2c(c1)nc(NCCN(C)C)n[n+]2[O-],,C1CCOC1,,[H-].[Na+],,val
US20120101147A1,CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1N.NS(=O)(=O)c1ccc(C(=O)O)cc1>>Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(S(N)(=O)=O)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05965756,CC(C)(C)N.CC1=C(C)C([Si](C)(C)Cl)c2cc3c(cc21)CCC3>>CC1=C(C)C([Si](C)(C)NC(C)(C)C)c2cc3c(cc21)CCC3,,CCCCCC,,CCN(CC)CC,,val
US20080085890A1,CC=O.O=C1NC(=O)c2ccc(I)cc2/C1=C/Nc1ccc(N2CCNCC2)nc1>>CCN1CCN(c2ccc(N/C=C3\C(=O)NC(=O)c4ccc(I)cc43)cn2)CC1,,CN1CCCC1=O,ClCCl,CC(=O)O,O=C([O-])O.[Na+],val
US20060276464A1,CCCc1ccc(S(=O)(=O)c2ccc(F)cc2)cc1S(=O)(=O)Cl.NCCc1ccccc1>>CCCc1ccc(S(=O)(=O)c2ccc(F)cc2)cc1S(=O)(=O)NCCc1ccccc1,,ClCCl,,,,val
US20090088445A1,Cc1ccc(S(=O)(=O)n2ccc3c(C(=O)CBr)ncnc32)cc1.NC(N)=S>>Cc1ccc(S(=O)(=O)n2ccc3c(-c4csc(N)n4)ncnc32)cc1,,CC(C)=O,,,,val
US20090137580A1,Cn1ccc2ncnc(Oc3ccc(N)c(Cl)c3)c21.Nc1ccc(CN2CCOCC2)c(C(F)(F)F)c1.O=C(Cl)Oc1ccccc1>>Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4ccc(CN5CCOCC5)c(C(F)(F)F)c4)c(Cl)c3)c21,,CN1CCCC1=O,,c1ccncc1,,val
US20140350019A1,CC(C)OC(=O)CBr.Cc1cc(-c2cccc(F)c2)cc(CNc2c(C)ccc(O)c2C)c1C>>Cc1cc(-c2cccc(F)c2)cc(CNc2c(C)ccc(OCC(=O)OC(C)C)c2C)c1C,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20120302564A1,Cc1nc2ccc(Cl)cc2nc1Cl.NN>>Cc1nc2ccc(Cl)cc2nc1NN,,CCO,ClCCl,O,,val
US20110301155A1,CC(C)(C)C(=O)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)c2[nH]ncc2c1.O=C1CCC(=O)N1Br>>CC(C)(C)C(=O)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)c2[nH]nc(Br)c2c1,,CCOC(C)=O,CN(C)C=O,,,val
US05958918,COc1ccc2ccc(S(=O)(=O)Cl)cc2c1.N#Cc1ccc(CN2CCC(N)C2=O)o1>>COc1ccc2ccc(S(=O)(=O)N[C@H]3CCN(Cc4ccc(C#N)o4)C3=O)cc2c1,,ClCCl,,Cl,,val
US20120232083A1,COc1ccc(B(O)O)cc1F.C[C@@](CCn1cc(F)c(I)cc1=O)(C(=O)NOC1CCCCO1)S(C)(=O)=O>>COc1ccc(-c2cc(=O)n(CC[C@](C)(C(=O)NOC3CCCCO3)S(C)(=O)=O)cc2F)cc1F,[Pd],C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20140179666A1,CC(=O)N1CC(C)(C)c2cc(F)c(S(=O)(=O)CCCCl)cc21>>CC(=O)N1CC(C)(C)c2cc(F)c(S(=O)(=O)C3CC3)cc21,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20100279311A1,CCOC(=O)CCSc1sc(C)c(C)n2c(=O)[nH]/c(=N\S(=O)(=O)c3ccc(C)cc3)c1-2>>Cc1ccc(S(=O)(=O)/N=c2\[nH]c(=O)n3c(C)c(C)sc(S)c2-3)cc1,,C1CCOC1,CO,Cl,[K+].[OH-],val
US20150166564A1,O=C(Nc1cc(CO)nn1-c1ccccc1)Oc1ccccc1.O=C1CCC(=O)N1Br>>O=C(Nc1c(Br)c(CO)nn1-c1ccccc1)Oc1ccccc1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20100160389A1,CCOC(=O)C(C(=O)OCC)c1cc(N)c(C)cc1Cl>>CCOC(=O)Cc1cc(N)c(C)cc1Cl,,CS(C)=O,O,[Cl-].[Li+],,val
US20040180939A1,O=C1CCOc2ccccc21>>OC1CCOc2ccccc21,,CO,,[BH4-].[Na+],,val
US20110251169A1,CC1(C)CNC(=O)N1.Fc1cc(I)cnc1F>>CC1(C)CN(c2ncc(I)cc2F)C(=O)N1,,Cc1ccccc1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040204397A1,O=c1[nH]c2c(F)cccc2c(=O)n1C1CCN(Cc2ccccc2)CC1>>O=c1[nH]c2c(F)cccc2c(=O)n1C1CCNCC1,[Pd],CO,,,,val
US20100261725A1,CCOC(=O)CC#N.COc1cc(C(C)=O)cc(OC)c1OC.O=C(Nc1scc(-c2ccc(Cl)cc2)c1C(=O)O)c1nc2cc(Br)ccc2o1>>CCOC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)csc1N,,Cc1ccccc1,,C1COCCN1,,val
US20040002507A1,Nc1ccc(Sc2ccncc2)c(F)c1.Nc1nc(Cl)cc(Cl)n1>>Nc1nc(Cl)cc(Nc2ccc(Sc3ccncc3)c(F)c2)n1,Cl,O,,[NH4+].[OH-],,val
US20090062342A1,Cc1cc(Cl)c(OCCOc2ccc([C@@]3(O)CCN(C(=O)OC(C)(C)C)C[C@@H]3C(=O)N(Cc3cccc(C)c3C)C3CC3)cc2)c(Cl)c1>>Cc1cc(Cl)c(OCCOc2ccc([C@@]3(O)CCNC[C@@H]3C(=O)N(Cc3cccc(C)c3C)C3CC3)cc2)c(Cl)c1,,C1COCCO1,,Cl,,val
US20090062279A1,COc1cccc2ncc(Br)cc12.CSSC>>COc1cccc2ncc(SC)cc12,,C1CCOC1,,,,val
US20150329538A1,CI.O=c1c2cccc(Br)c2[nH]c(=S)n1-c1ccccc1>>CSc1nc2c(Br)cccc2c(=O)n1-c1ccccc1,,C1CCOC1,,O,O=C([O-])[O-].[K+].[K+],val
US20090270361A1,CN(C)C=O.Cc1cc(C)n(-c2ccc(Br)cc2)n1>>Cc1nn(-c2ccc(Br)cc2)c(C)c1C=O,,CCOC(C)=O,,O=P(Cl)(Cl)Cl,,val
US20150152093A1,Cc1cc([C@H](C)NC(=O)OC(C)(C)C)ncc1-c1ccnc(C(F)(F)F)c1>>Cc1cc([C@H](C)N)ncc1-c1ccnc(C(F)(F)F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050282824A1,COC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)c1cc(N2CCCCC2)nc(N2CCC(c3ccccc3)CC2)n1>>O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)c1cc(N2CCCCC2)nc(N2CCC(c3ccccc3)CC2)n1,,ClCCl,,CO,[Na+].[OH-],val
US05969138,CCO.COCCN1CCN(C[C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1.O=S(=O)(O)O>>COCCN1CCN(C[C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1.O.O=S(=O)(O)O,,CCO,,,,val
US20140275016A1,CC(C)C(=O)Nc1cc(Oc2ccc([N+](=O)[O-])nc2)ccn1>>CC(C)C(=O)Nc1cc(Oc2ccc(N)nc2)ccn1,[Ni],CO,,NN,O,val
US20080255386A1,CCCCCN(C)CCC(=O)OC>>CCCCCN(C)CCC(=O)O,,O,,,,val
US20100029952A1,CI.[N-]=[N+]=Nc1ccc(C=Cc2ccncc2)cc1>>C[n+]1ccc(C=Cc2ccc(N=[N+]=[N-])cc2)cc1.[I-],,CC#N,,,,val
US05618941,CC(O)(c1ccc(F)cc1)c1cc(Br)cc(Br)c1.CN(C)C=O>>CC(O)(c1ccc(F)cc1)c1cc(Br)cc(C=O)c1,,CCCCCC,CCOCC,[Li]CCCC,,val
US20100016282A1,C[C@@H]1NCCN(CCCN2CCCCC2)C1=O.O=C=Nc1cccc(C(F)(F)F)c1>>C[C@H]1C(=O)N(CCCN2CCCCC2)CCN1C(=O)Nc1cccc(C(F)(F)F)c1,,CC#N,,,,val
US20100173886A1,CC(C)CCON=O.O=C1CCc2cc(F)c(F)cc21>>O=C1C(=NO)Cc2cc(F)c(F)cc21,,CO,,Cl,O,val
US20060247227A1,C1CC(N2CCC(OC3CCNCC3)CC2)C1.FC(F)(F)c1ccc(Cl)nn1>>Cl.FC(F)(F)c1ccc(N2CCC(OC3CCN(C4CCC4)CC3)CC2)nn1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04548818,Nc1c(N=O)c(=O)[nH]c(=O)n1C1CCC1>>Nc1c(N)n(C2CCC2)c(=O)[nH]c1=O,O=[Pt]=O,CN(C)C=O,,,,val
US05624950,CC(=O)OC1CCC2CN(Cc3ccccc3)CC2C1=O.COc1ccccc1[Mg]Br>>COc1ccccc1C1(O)C(O)CCC2CN(Cc3ccccc3)CC21,,C1CCOC1,CCOCC,[Cl-].[NH4+],,val
US20080096897A1,Nc1ccc(N2CCN(C3(c4ccc(-c5ccccc5)cc4)C(=O)NC(=O)NC3=O)CC2)cc1.O=C1CCC(=O)O1>>O=C(O)CCC(=O)Nc1ccc(N2CCN(C3(c4ccc(-c5ccccc5)cc4)C(=O)NC(=O)NC3=O)CC2)cc1,,CCOC(C)=O,CN(C)C=O,,,val
US05123951,CCOC(=O)C[N+](=O)[O-].Cc1cc(Br)ccc1N=C=O>>CCOC(=O)C(C(=O)Nc1ccc(Br)cc1C)[N+](=O)[O-],,c1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20050038101A1,Brc1ccccc1.CCOC(=O)c1cc2cc([N+](=O)[O-])ccc2[nH]1>>CCOC(=O)c1cc2cc([N+](=O)[O-])ccc2n1-c1ccccc1,Br[Cu]Br,,,O=C([O-])[O-].[K+].[K+],,val
US20160264582A1,C[C@@H](O)CC(=O)O.O=C1[C@H]2CNC[C@H]2CN1c1cccc2c1cnn2-c1ccccc1F>>C[C@@H](O)CC(=O)N1C[C@H]2CN(c3cccc4c3cnn4-c3ccccc3F)C(=O)[C@H]2C1,,C1CCOC1,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US20050124656A1,CCCCCCCCCCCCNS(=O)(=O)c1ccc(CN)s1.O=Cc1ccc(C(F)(F)F)cc1>>CCCCCCCCCCCCNS(=O)(=O)c1ccc(CNCc2ccc(C(F)(F)F)cc2)s1,,ClCCCl,,O=C([O-])O.[Na+],,val
US20160270399A1,Cc1cccc(-n2nnn(C)c2=O)c1CO.Clc1nc(Br)ns1>>Cc1cccc(-n2nnn(C)c2=O)c1COc1nc(Br)ns1,,COCCOC,,[H-].[Na+],,val
US20150284411A1,CI.C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@H]3[C@@H]2OC[C@H]3O)nc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc21>>CO[C@@H]1CO[C@@H]2[C@H](Oc3nc4nc(-c5ccc(-c6ccccc6)cc5)c(Cl)cc4n3COCC[Si](C)(C)C)CO[C@@H]21,,CCOC(C)=O,CN(C)C=O,CCCCCC,[H-].[Na+],val
US20090233979A1,O=[N+]([O-])c1ccc(F)cc1.Oc1c(Cl)cc(Br)cc1Cl>>O=[N+]([O-])c1ccc(Oc2c(Cl)cc(Br)cc2Cl)cc1,[Cu],CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06043248,C1COCCN1.ClCc1ccncc1>>c1cc(CN2CCOCC2)ccn1,,ClCCl,,Cl,O,val
US20040029290A1,Nc1ccccc1O.O=Cc1cc(CCC(=O)O)ccc1O>>O=C(O)CCc1ccc(O)c(C=Nc2ccccc2O)c1,,CCO,,,,val
US04997835,Clc1cccc(Cl)n1.NN>>NNc1cccc(Cl)n1,,CO,,O,,val
US05194446,NS(=O)(=O)Cl.OCCc1ccccc1>>NS(=O)(=O)OCCc1ccccc1,,CC#N,,,,val
US05064844,CCS.FC(F)(F)c1cc(Cl)c(-n2ncc(CBr)n2)c(Cl)c1>>CCSCc1cnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)n1,,C1CCOC1,,O,[H-].[Na+],val
US04528114,C(=NC1CCCCC1)=NC1CCCCC1.CCCCC[C@@H]1CC[C@@H](C(=O)O)CC1.CCOCC.CN(C)c1ccncc1>>C#Cc1ccc(OC(=O)[C@@H]2CC[C@@H](CCCCC)CC2)cc1,CN(C)c1ccncc1,,,,,val
US20130281433A1,BrC(Br)(Br)Br.CC(C)N1CCN(c2cncs2)CC1>>CC(C)N1CCN(c2cnc(Br)s2)CC1,,C1CCOC1,,[Li]CCCC,,val
US20090275558A1,CCOC(=O)c1cc2c(s1)CCN(C(=O)OCC)C2.Cl>>Cl.O=C(O)c1cc2c(s1)CCNC2,,[K+],[OH-],,,val
US20030087925A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=C1CC[C@@H](CO)N1>>Cc1ccc(S(=O)(=O)OCC2CCC(=O)N2)cc1,,ClCCl,,CCN(CC)CC,,val
US20060100298A1,CCC(=O)C(O)c1ccc(N2CCOCC2)cc1.Cc1ccc(CBr)cc1>>CCC(=O)C(O)(Cc1ccc(C)cc1)c1ccc(N2CCOCC2)cc1,,CS(C)=O,O,[Na+].[OH-],,val
US04232035,CN1C(=O)C(C)(C)SC1=NO.Cc1ccc(SSN(C)C(=O)F)cc1>>Cc1ccc(SSN(C)C(=O)ON=C2SC(C)(C)C(=O)N2C)cc1,,C1COCCO1,,CCN(CC)CC,,val
US20140357664A1,C=CB(OCCCC)OCCCC.C[C@H]1c2cccc(Br)c2C[C@H](CO[Si](C)(C)C(C)(C)C)N1C(=O)Cc1c(F)cccc1Cl>>C=Cc1cccc2c1C[C@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)Cc1c(F)cccc1Cl)[C@H]2C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20110172436A1,CNN.O=Cc1ccccc1>>CNN=Cc1ccccc1,,CCOCC,,,,val
US20060148858A1,CCOC(=O)c1cn(CC)nc1OCc1ccccc1>>CCn1cc(CO)c(OCc2ccccc2)n1,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20090227591A1,CCOC(=O)c1ncccc1C.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)c1c(C)ccc[n+]1[O-],,ClCCl,,,,val
US20060148858A1,CCOC(=O)CCc1c[nH]nc1OCc1ccccc1.FC(F)(F)c1ccc(Cl)nc1>>CCOC(=O)CCc1cn(-c2ccc(C(F)(F)F)cn2)nc1OCc1ccccc1,,O,,CN(C)C=O,[H-].[Na+],val
US20150232465A1,CC(=O)N1c2ccc(-c3cn[nH]c3)cc2N(C(=O)OCC2CC2)C[C@@H]1C.CS(=O)(=O)OC1CCS(=O)(=O)CC1>>CC(=O)N1c2ccc(-c3cnn([C@H]4CCCS(=O)(=O)C4)c3)cc2N(C(=O)OCC2CC2)C[C@@H]1C,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20090221555A1,COC(=O)CBr.O=C1CCCc2cc([N+](=O)[O-])ccc2N1>>COC(=O)CN1C(=O)CCCc2cc([N+](=O)[O-])ccc21,,CN(C)C=O,,[H-].[Na+],,val
US20050070585A1,CC/C(=C/CNO)c1ccc2c(Cc3ccccc3)c(CC)oc2c1.O=C=NC(=O)Cl>>CC/C(=C/Cn1oc(=O)[nH]c1=O)c1ccc2c(Cc3ccccc3)c(CC)oc2c1,,C1CCOC1,,Cl,,val
US05610303,CC(=O)N1CCC(/C=C/C(=O)c2ccc([N+](=O)[O-])cc2)CC1>>CC(=O)N1CCC(CCC(=O)c2ccc(N)cc2)CC1,O=[Pt],CO,,,,val
US20090291971A1,N#Cc1cccc(B(O)O)c1.c1cnc2c(c1)nnn2Oc1ncnc2sccc12>>N#Cc1cccc(Oc2ncnc3sccc23)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06184398B2,CC[Si](CC)(CC)OC(C)(C)C#CCBr.C[C@H](O)C1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C>>CC[Si](CC)(CC)OC(C)(C)C#CCO[C@@H](C)C1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C,,C1CCOC1,O,C1COCCOCCOCCOCCO1,[H-].[Na+],val
US05672586,C[C@H](Cc1ccccc1)C(=O)O>>C[C@H](CC1CCCCC1)C(=O)O,[Rh],CO,,,,val
US20160068494A1,COC(=O)CNC(=O)c1cc(I)ccc1N.O=C(Cl)c1cccc(Cl)c1>>COC(=O)CNC(=O)c1cc(I)ccc1NC(=O)c1cccc(Cl)c1,,C1CCOC1,,CCN(CC)CC,,val
US20010027196A1,C1CCNCC1.CS(=O)(=O)c1nc(N)nc(-c2ccccc2)c1C#N>>N#Cc1c(-c2ccccc2)nc(N)nc1N1CCCCC1,,COCCOC,,,,val
US07723376B2,C=CCCCBr.COc1ccc(CN)c(OC)c1>>C=CCCCNCc1ccccc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US05278148,CC(C)(C)OC(=O)n1cncc1C[C@H](NC(=O)[C@@H](CC(=O)C(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CN1CCCC1=O>>CC(C)(C)C(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CN1CCCC1=O,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20110301161A1,CC1(C)OB(c2cn[nH]c2)OC1(C)C.O=Cc1ccccc1Br>>O=Cc1ccccc1-c1cn[nH]c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],val
US04007179,CCOC(=O)C(C)c1ccc(CC(CC)(C(=O)OCC)C(=O)OCC)cc1>>CCC(Cc1ccc(C(C)C(=O)O)cc1)C(=O)O,,CCO,,O,[K+].[OH-],val
US20160016908A1,CC(=O)N1c2ccc(OC3CCOC3)cc2[C@H](NC(=O)OCc2ccccc2)[C@@H](C)[C@@H]1C1CC1>>CC(=O)N1c2ccc(OC3CCOC3)cc2[C@H](N)[C@@H](C)[C@@H]1C1CC1,,C1CCOC1,CO,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100152257A1,CCOC(=O)C(C)c1ccc(Br)cc1.Cc1noc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c1NC(=O)OC(C)c1ccccc1F>>CCOC(=O)C(C)c1ccc(-c2ccc(-c3onc(C)c3NC(=O)OC(C)c3ccccc3F)cc2)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,,,val
US20020052498A1,CCCCCCCCCCCCCCCCCCOc1ccccc1CCC(=O)NCCCN1CCOCC1.Cl>>CCCCCCCCCCCCCCCCCCOc1ccccc1CCC(=O)NCCCN1CCOCC1.Cl,,CCOC(C)=O,,,,val
US05328924,CI.FC(F)(F)CCCCCOc1nsnc1-c1cccnc1>>C[n+]1cccc(-c2nsnc2OCCCCCC(F)(F)F)c1.[I-],,CC(C)=O,,,,val
US05772990,CCCCNc1cc(Cl)nc(N)[n+]1[O-].CNC>>CCCCNc1cc(N(C)C)nc(N)[n+]1[O-],,CCO,O,[Na+].[OH-],,val
US20110039842A1,CON(C)C(=O)c1nc2ccc(N3CCOCC3)cn2c(=O)c1OCc1ccccc1>>O=Cc1nc2ccc(N3CCOCC3)cn2c(=O)c1OCc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05852011,O=[N+]([O-])c1ccc(F)c(F)c1.OCCNCCO>>O=[N+]([O-])c1ccc(N(CCO)CCO)c(F)c1,,CS(C)=O,,CCCCCC,CCOC(C)=O,val
US20110144105A1,COCC#Cc1cnc2c(c1)cc(C(=O)CC1CCCC1)n2S(=O)(=O)c1ccccc1.Cc1ccc(S(=O)(=O)OS(=O)(=O)c2ccc(C)cc2)cc1>>COCC#Cc1cnc2c(c1)cc(C(=CC1CCCC1)OS(=O)(=O)c1ccc(C)cc1)n2S(=O)(=O)c1ccccc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100016349A1,CC(=O)OCc1cocc2c(C=O)ccc1-2.CN(C)CCCN>>c1cc2cc[nH]cc-2c1,,ClC(Cl)Cl,,,,val
US20080113966A1,N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.O=c1[nH]c(-c2ccccc2)nn1C1CCNCC1>>O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC(n2nc(-c3ccccc3)[nH]c2=O)CC1,,C1CCOC1,,CCN(CC)CC,O=C([O-])[O-].[Na+].[Na+],val
US20060094767A1,CC(C)(C)OC(=O)CCC1(C)Cn2cc([N+](=O)[O-])nc2O1>>CC1(CCC(=O)O)Cn2cc([N+](=O)[O-])nc2O1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120208828A1,Cc1ccc(-c2nnc(CCl)o2)cc1.Nc1ncc(-c2nnc(S)n2-c2ccccc2Cl)cn1>>Cc1ccc(-c2nnc(CSc3nnc(-c4cnc(N)nc4)n3-c3ccccc3Cl)o2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2cc(F)c(O[C@H]3CCC[C@@H]3c3ccnn3C)cc2F)c(OC)c1>>Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(S(=O)(=O)Nc2ccncn2)cc1F,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US05827887,COC(=O)c1ccc(-c2ccc(OCc3ccccc3)cc2)c(Cl)c1>>COC(=O)c1ccc(-c2ccc(O)cc2)c(Cl)c1,[Pd],CCOC(C)=O,,,,val
US20060026772A1,NC(=O)CCl.Nc1ccc([N+](=O)[O-])cc1>>NC(=O)CNc1ccc([N+](=O)[O-])cc1,,CCO,O,O=C([O-])[O-].[Ca+2],,val
US20140336377A1,Cl.[N-]=[N+]=NCc1ccc(OCC(F)(F)C(F)F)nc1>>Cl.NCc1ccc(OCC(F)(F)C(F)F)nc1,[Pd],CO,,,,val
US05108486,CC#N.CCI.Cn1nc(C(F)(F)F)n(-c2ccc(N)cc2Cl)c1=S>>CCN(CC)c1ccc(-n2c(C(F)(F)F)nn(C)c2=S)c(Cl)c1,,O,,O=C([O-])O.[Na+],,val
US20120295884A1,CN1CCN(C(=O)c2cc(Cl)c(F)c(CNC(=O)OC(C)(C)C)c2)CC1>>CN1CCN(C(=O)c2cc(Cl)c(F)c(CN)c2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090264399A1,CC(C)[Si](Cl)(C(C)C)C(C)C.CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCC[C@@H](CO)C1>>CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCC[C@@H](CO[Si](C(C)C)(C(C)C)C(C)C)C1,,CCOC(C)=O,CN(C)C=O,O,c1c[nH]cn1,val
US20090181958A1,CC(C)(C)OC(=O)CCC[C@H](N)c1nc2cc(Cl)ccc2[nH]1.O=C(c1cc2ncnc(Cl)c2cc1Cl)N1CC=CC1>>CC(C)(C)OC(=O)CCC[C@H](Nc1ncnc2cc(C(=O)N3CC=CC3)c(Cl)cc12)c1nc2cc(Cl)ccc2[nH]1,,CN(C)C=O,,CCN(CC)CC,,val
US20100222581A1,CCCN(CCC)C(=O)c1cc(C(=O)O)cc(-c2ncco2)c1.CCCS(=O)(=O)[C@@H]1C[C@H]([C@@H](O[Si](C)(C)C(C)(C)C)[C@H](Cc2ccccc2)NC(=O)c2cc(NC(=O)c3ccccc3)cc(-c3ncco3)c2)N(C(=O)OC(C)(C)C)C1>>CCCN(CCC)C(=O)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)[C@H]2C[C@@H](S(=O)(=O)CCC)CN2)cc(-c2ncco2)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150141406A1,COc1nccc2c1c(-c1csc(C(N)=O)c1)nn2C1CCC2(CC1)OCCO2>>NC(=O)c1cc(-c2nn(C3CCC(=O)CC3)c3cc[nH]c(=O)c23)cs1,,O,,C1CCOC1,Cl,val
US20100056788A1,COC(=O)c1ccc(-c2ccccc2)nc1Cl>>OCc1ccc(-c2ccccc2)nc1Cl,,O,,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20040034071A1,CC(C)(C)OC(=O)CN(CCN1CCOCC1)S(=O)(=O)c1ccc(Sc2ccccc2)cc1.Cl>>Cl.O=C(O)CN(CCN1CCOCC1)S(=O)(=O)c1ccc(Sc2ccccc2)cc1,,O,,CC(C)=O,,val
US20030105342A1,C/C=C/c1ccc2ncccc2c1OCc1ccccc1.O=[O+][O-]>>O=Cc1ccc2ncccc2c1OCc1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05872115,CCN(CC)c1ccc([N+](=O)[O-])c(C(=O)NCC2CCN(C(c3ccccc3)c3ccccc3)CC2)c1>>CCN(CC)c1ccc(N)c(C(=O)NCC2CCN(C(c3ccccc3)c3ccccc3)CC2)c1,O=[Pt]=O,,,,,val
US20120157479A1,Br[Mg]c1ccccc1.O=C(OCc1ccccc1)N1CC2OC2C1>>O=C(OCc1ccccc1)N1C[C@@H](O)[C@H](c2ccccc2)C1,,C1CCOC1,,CSC,,val
US05753714,CCCCN(CCCN(CCCCCCCCN(CCCN(CCCC)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>CCCCNCCCNCCCCCCCCNCCCNCCCC,,CCO,CCOCC,Cl,,val
US06482478B1,CCCCCCBr.Oc1cccc(Br)c1F>>CCCCCCOc1cccc(Br)c1F,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130085131A1,COC(=O)c1c(OC)c(C(C)Nc2ncnc(N)c2C#N)nc2ccc(F)cc12>>COc1c(C(C)Nc2ncnc(N)c2C#N)nc2ccc(F)cc2c1C(=O)O,,C1CCOC1,CC(C)(C)O,[Li+].[OH-],,val
US20120015958A1,CC(C)(C)OC(=O)N1CCNCC1.COC(=O)c1coc(CCl)n1>>COC(=O)c1coc(CN2CCN(C(=O)OC(C)(C)C)CC2)n1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US04931436,CCN(CC)CCC1CCNC1.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>CCN(CC)CCC1CCN(C(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1,,CCOC(C)=O,CO,,,val
US20120316161A1,CCCC(C(=O)OCC)c1c(C)nc2c(Br)cnn2c1Cl.CCN(C(C)C)C(C)C.COCCOC.Cc1ccc(B(O)O)cc1>>CCCC(C(=O)OCC)c1c(C)nc2c(-c3ccc(C)cc3)cnn2c1-c1ccc(C)cc1,,COCCOC,O,,,val
US20100048666A1,CCOC(=O)C(C)c1ccc(C(O)C2CCCS2(=O)=O)cc1.O=S(Cl)Cl>>CCOC(=O)C(C)c1ccc(C(Cl)C2CCCS2(=O)=O)cc1,,C1COCCO1,,,,val
US20150080364A1,CC(C)(C)OC(=O)N1CCN(Cc2cc(C(F)(F)F)ccc2N2CCCC2)CC1>>FC(F)(F)c1ccc(N2CCCC2)c(CN2CCNCC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04145432,CCOC(=O)C1=C(C)NC(CO)=C(C(=O)OCC)C1c1cccs1>>CCOC(=O)C1=C(C)NC2=C(C(=O)OC2)C1c1cccs1,,CCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110172237A1,BrCCc1cnccn1.O=C(O[C@H]1CN2CCC1CC2)C1(c2ccccc2)CCCCCC1>>O=C(O[C@H]1C[N+]2(CCc3cnccn3)CCC1CC2)C1(c2ccccc2)CCCCCC1.[Br-],,CC#N,,,,val
US20140275015A1,c1ccc(CN2CCc3c(ncn3-c3ccccn3)C2)cc1>>c1ccc(-n2cnc3c2CCNC3)nc1,,ClCCCl,,CC(Cl)OC(=O)Cl,,val
US04054579,CN(C)C=O.Cc1cccc(C=Cc2ccccc2C(=O)O)c1>>O=C(O)c1ccccc1CCCCc1ccccc1,[Pd],,,,,val
US20080207654A1,CCCCc1nc(C)n(C(C)C)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCCc1nc(C)n(C(C)C)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20130317001A1,CC(C)(C)[Si](C)(C)Cl.COC(=O)c1cc(Cl)c(OCC23CC4CC(CC(CO)(C4)C2)C3)cc1F>>COC(=O)c1cc(Cl)c(OCC23CC4CC(C2)CC(CO[Si](C)(C)C(C)(C)C)(C4)C3)cc1F,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20140163024A1,CC(C)CBr.COC(=O)c1ccc(S(=O)(=O)Nc2ccc(F)cc2)cc1>>COC(=O)c1ccc(S(=O)(=O)N(CC(C)C)c2ccc(F)cc2)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20100152166A1,BrC(Br)(Br)Br.OCc1c(-c2c(Cl)cccc2Cl)noc1C1CC1>>Clc1cccc(Cl)c1-c1noc(C2CC2)c1CBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120040991A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2C[C@H]1CO.FC(F)(F)c1cnc(Br)cn1>>CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2C[C@H]1COc1cnc(C(F)(F)F)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20100081644A1,CC(C)(CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)c1cc(NC(=O)C(C)(C)S(=O)(=O)CC2CCC(=O)CC2)on1>>CC(C)(CO)c1cc(NC(=O)C(C)(C)S(=O)(=O)CC2CCC(=O)CC2)on1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090299072A1,CCOC(=O)Cc1cc(Cl)c(OCC2CC2)c(-c2ccc(C(F)(F)F)cc2)c1.FC(F)(F)CI>>CCOC(=O)C(CC(F)(F)F)c1cc(Cl)c(OCC2CC2)c(-c2ccc(C(F)(F)F)cc2)c1,,CN(C)C=O,O,Cl,[H-].[Na+],val
US05210211,CC(=O)O.CCCc1nc(N)c(C(=O)OC)[nH]1.COC1CCC(OC)O1>>CCCc1nc(-n2cccc2)c(C(=O)OC)[nH]1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20090042856A1,CCOC(=O)CCN1CCn2nc(-c3ccc(F)cc3)c(-c3ccc(=O)n(-c4ccccc4C)n3)c21>>Cc1ccccc1-n1nc(-c2c(-c3ccc(F)cc3)nn3c2N(CCC(=O)O)CC3)ccc1=O,,CCO,,[Na+].[OH-],,val
US20070003539A1,CC(C)Sc1ccccc1C=CC(=O)OC(C)(C)C.C[C@H](NCc1ccccc1)c1ccccc1>>CC(C)Sc1ccccc1[C@@H](CC(=O)OC(C)(C)C)N(Cc1ccccc1)[C@@H](C)c1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20150133446A1,CCC(=O)C(=O)C(F)(F)F.COC(=O)c1ccc(N)o1>>COC(=O)c1cc2c(C(F)(F)F)cc(C)nc2o1,,CC(=O)O,,,,val
US05644016,C=Cc1ccccc1.CCOC(=O)N=NC(=O)[O-].CN(C)C=O.CO.O=C1C=CC(=O)N1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C=Cc1ccccc1.CCCCOC(=O)CCN1C(=O)C=CC1=O,,CN(C)C=O,,,,val
US20130203768A1,COc1cc(N2CCNCC2)cc(OC)n1.O=C(O)/C=C/C(F)(F)C(F)(F)F>>COc1cc(N2CCN(C(=O)/C=C/C(F)(F)C(F)(F)F)CC2)cc(OC)n1,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060084802A1,CCCCCOC(=O)c1cc(NS(=O)(=O)c2ccc(Cl)cc2Cl)ncc1Sc1ccc(S(=O)(=O)N2CCCCC2)cc1>>O=C(O)c1cc(NS(=O)(=O)c2ccc(Cl)cc2Cl)ncc1Sc1ccc(S(=O)(=O)N2CCCCC2)cc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20130046093A1,CN(Cc1ccccc1)c1ccc2nc(-c3ccccc3)oc2n1>>CNc1ccc2nc(-c3ccccc3)oc2n1,,O,,O=S(=O)(O)O,[Na+].[OH-],val
US04198503,O=C(NC1C(=O)N2C(C(=O)O)=C(CO)CS[C@H]12)OCc1ccc([N+](=O)[O-])cc1.O=C=NS(=O)(=O)Cl>>NC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)OCc3ccc([N+](=O)[O-])cc3)[C@H]2SC1,,CC#N,,,,val
US06353017B1,CC(C)CC(N)C(=O)NC(C)(C)C#N.O=C(O)c1ccc(CBr)cc1>>CC(C)CC(NC(=O)c1ccc(CBr)cc1)C(=O)NC(C)(C)C#N,,CN(C)C=O,CN(C)C=O,On1nnc2ccccc21,,val
US20140163008A1,C/C(C#N)=C1/c2ccc(Cc3c(C4CC4)nc4c(Cl)nccn34)cc2COc2cc(F)ccc21.CNC>>C/C(C#N)=C1/c2ccc(Cc3c(C4CC4)nc4c(N(C)C)nccn34)cc2COc2cc(F)ccc21,,C1CCOC1,,O,,val
US04622415,CC(Oc1cccc(Oc2c(Cl)cc(C(F)(F)F)cc2Cl)c1)C(=O)O.O=S(Cl)Cl>>CC(Oc1cccc(Oc2c(Cl)cc(C(F)(F)F)cc2Cl)c1)C(=O)Cl,,Cc1ccccc1,,,,val
US07091216B2,CCOC(=O)COc1nc(-c2ccc(Cl)cc2Cl)c(-c2ccc(Cl)cc2)cc1C#N>>CCOC(=O)c1oc2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc2c1N,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20130303524A1,COc1ccc(CN2CCCC(F)(F)S2(=O)=O)c(OC)c1>>O=S1(=O)NCCCC1(F)F,,ClCCl,,O=C(O)C(F)(F)F,,val
US06359134B1,CC(C)NC(C)C.COC(=O)c1ccc(CBr)cc1OC>>COc1cc(CN(C(C)C)C(C)C)ccc1C(=O)O,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150099782A1,CCNN.O=Cc1c(F)cc(Br)cc1F>>CCn1ncc2c(F)cc(Br)cc21,,CN1CCCC1=O,,O=C(O)C(=O)O,,val
US20060217372A1,BrCCc1ccccc1.NC(=O)c1ccc(Oc2ccc3c(c2)CCNC3)nc1>>NC(=O)c1ccc(Oc2ccc3c(c2)CCN(CCc2ccccc2)C3)nc1,,CCOC(C)=O,O,CCN(CC)CC,CN(C)C=O,val
US20100056507A1,CC1(C)CCC(C)(C)c2cc(C(=O)O)ccc21.C[Si](C)(C)C=[N+]=[N-]>>CC1(C)CCC(C)(C)c2cc(C(=O)NN)ccc21,,CO,,,,val
US20110081365A1,C/C=C/c1cnc2c(N)nc3cc(C)ccc3c2c1>>CCCc1cnc2c(N)nc3cc(C)ccc3c2c1,[Pd],CCOC(C)=O,CO,[H][H],,val
US20140100231A1,COc1ccc(COc2nc(C(N)=O)ncc2CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cc1>>COc1ccc(COc2nc(C(N)=O)ncc2CO)cc1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US06884821B1,CCOC(=O)C(CC)Cc1ccc(OC)c(CNC(=O)c2ccc(C(F)(F)F)cc2)c1>>CCC(Cc1ccc(OC)c(CNC(=O)c2ccc(C(F)(F)F)cc2)c1)C(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20080292548A1,CNC.COC(=O)c1cc(F)c(F)cc1Cl>>COC(=O)c1cc(F)c(N(C)C)cc1Cl,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120108566A1,CN(C)C=O.NC(=O)c1cnc(Nc2ccc(C3CCNCC3)cc2)cc1NCc1cccc(F)c1F>>NC(=O)c1cnc(Nc2ccc(C3CCN(C=O)CC3)cc2)cc1NCc1cccc(F)c1F,,CN(C)C=O,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20150175623A1,CCOC(=O)[C@H](O)Cc1ccccc1OC[C@H]1CCCO1.Fc1ccc(-c2sc3ncnc(Cl)c3c2Br)cc1>>CCOC(=O)[C@@H](Cc1ccccc1OC[C@H]1CCCO1)Oc1ncnc2sc(-c3ccc(F)cc3)c(Br)c12,,CC(C)(C)O,O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20070032485A1,CCOC(=O)CCCOc1cnc(N[C@H]2C[C@@H](CC)N(C(=O)OCC)c3ccc(OC)nc32)nc1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(OCCCC(=O)O)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC,,CCO,,[Na+].[OH-],,val
US07807673B2,O=C(NC1Cc2ccc([N+](=O)[O-])cc2C1)C(F)(F)F>>Nc1ccc2c(c1)CC(NC(=O)C(F)(F)F)C2,[Pd],CCOC(C)=O,,,,val
US06307056B1,COc1cc[nH]c1/C=C1\C(=O)Nc2ccc(N)c(-c3ccc4cc[nH]c4c3)c21.O=C(Cl)Cc1cccs1>>COc1cc[nH]c1/C=C1\C(=O)Nc2ccc(NC(=O)Cc3cccs3)c(-c3ccc4cc[nH]c4c3)c21,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US06960586B2,Cc1c(O[Si](C)(C)C(C)(C)C)ccc2cc(C(=O)c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)ccc12>>Cc1c(O)ccc2cc(C(=O)c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)ccc12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20040116694A1,CCOc1ccc2c([N+](=O)[O-])cccc2n1>>CCOc1ccc2c(N)cccc2n1,[Pd],CCOC(C)=O,,[H][H],,val
US04017633,CC(=O)c1c(O)oc(=O)c(C(C)=O)c1O.Nc1ccccc1N>>CC(=O)C1=C(O)C(=C(C)Nc2ccccc2N)C(=O)OC1=O,,CO,,,,val
US20120232083A1,CCOC(=O)[C@@](C)(CCBr)S(C)(=O)=O.O=c1cc(I)c(F)c[nH]1>>CCOC(=O)[C@@](C)(CCn1cc(F)c(I)cc1=O)S(C)(=O)=O,,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070099990A1,CCOC(C)=O.Cc1c(Br)c2c(c(C)c1NC(=O)CC(C)(C)C)[C@@H](c1ccc(C(C)C)cc1)CO2>>COc1c(C)c(NC(=O)CC(C)(C)C)c(C)c2c1OC[C@@H]2c1ccc(C(C)C)cc1,,ClC(Cl)Cl,,CCCCCC,,val
US20070219228A1,CCOCc1nc2c(N)nc3cc(-c4cccc(CO)c4)cnc3c2n1CC(C)(C)O>>CC(C)(O)Cn1c(CO)nc2c(N)nc3cc(-c4cccc(CO)c4)cnc3c21,,ClCCl,,BrB(Br)Br,CO,val
US20110206653A1,CCOC(=O)c1ccc(OC)c(O)c1.Cc1cccc(C)c1CO>>CCOC(=O)c1ccc(OC)c(OCc2c(C)cccc2C)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070066583A1,COc1cc(N2CCN(C(=O)CCl)CC2)ccc1Cl.O=c1[nH]c2ccc(Cl)cc2o1>>COc1cc(N2CCN(C(=O)Cn3c(=O)oc4cc(Cl)ccc43)CC2)ccc1Cl,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US05631206,Cc1ccc([N+](=O)[O-])c(C(N)=S)c1.O=C(CBr)C(F)(F)F>>Cc1ccc([N+](=O)[O-])c(C2=NC(O)(C(F)(F)F)CS2)c1,,CCO,,CCCCCC,CCOC(C)=O,val
US20150307493A1,BrBr.N#Cc1ccc(O)c([N+](=O)[O-])c1>>N#Cc1cc(Br)c(O)c([N+](=O)[O-])c1,,O,,CC(=O)O,,val
US20140088074A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCOc1cccc(C(F)(F)CN)c1>>CCCCOc1cccc(C(F)(F)CNC(=O)OC(C)(C)C)c1,,C1CCOC1,,CCN(CC)CC,,val
US20050107616A1,CC(C)(C)[C@H](O)Cn1ccc(-c2ccc(C(F)(F)F)cc2)n1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CC(C)(C)[C@@H](Cn1ccc(-c2ccc(C(F)(F)F)cc2)n1)OC(=O)Oc1ccc([N+](=O)[O-])cc1,,ClCCl,,c1ccncc1,,val
US20130274260A1,Cc1cccc(B(O)O)c1.O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1cccc(CCl)c1>>Cc1cccc(Cc2cccc(C(=O)NCCc3c[nH]c4ccc(Cl)cc34)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,[I-].[Na+],,val
US20060223810A1,CC(C)(C)OC(=O)CBr.COc1ccc2nccc(-n3cc4c(n3)CCC(NCc3ccc5c(c3)NC(=O)CS5)C4)c2n1>>COc1ccc2nccc(-n3cc4c(n3)CCC(N(CC(=O)OC(C)(C)C)Cc3ccc5c(c3)NC(=O)CS5)C4)c2n1,,CN(C)C=O,,CCN(CC)CC,,val
US20150045523A1,CC(C)(C)c1cc2c(cc1Br)Cc1cc(Br)c(C(C)(C)C)cc1-2.CCO.COCCOC.OB(O)c1ccccc1>>CC(C)(C)c1cc2c(cc1-c1ccccc1)Cc1cc(-c3ccccc3)c(C(C)(C)C)cc1-2,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20130072487A1,CCOC(=O)CN=C=O.O=C1CC(=O)N(CCC2CC2)C(=O)N1CCC1CC1>>O=C(O)CNC(=O)c1c(O)n(CCC2CC2)c(=O)n(CCC2CC2)c1=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110195954A1,O=C(c1cc(Cl)c(I)cn1)N1CCc2cc(F)ccc21.O=c1[nH]c2ncccc2n1C1CCNCC1>>O=C(c1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c(I)cn1)N1CCc2cc(F)ccc21,,O,,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US06106908,C/C=C/C=C/C(=O)O.N#Cc1ccc(-c2ccc(O)cc2)cc1>>C/C=C/C=C/C(=O)Oc1ccc(-c2ccc(C#N)cc2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05541229,CCCSCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1.OO>>CCCS(=O)Cc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,CC(=O)O,,,,val
US05576322,CCOC(=O)C(Nc1ncnc2ccc(Cl)cc12)c1ccc2c(c1)OCO2.N>>NC(=O)C(Nc1ncnc2ccc(Cl)cc12)c1ccc2c(c1)OCO2,,CCO,,,,val
US09315514B2,BrCc1ccccc1.CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(O)c5c2[C@@]4(CCN1CC1CC1)[C@H]3O5>>CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(OCc5ccccc5)c5c2[C@@]4(CCN1CC1CC1)[C@H]3O5,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20020052322A1,COC(=O)C(C)(C)N.C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O>>COC(=O)C(C)(C)NC(=O)[C@H](C)NC(=O)Cc1cc(F)cc(F)c1,,CO,ClC(Cl)Cl,,,val
US20120142707A1,C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CCC4[C@@]5(C)CC=C(c6cccc(C(=O)O)c6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>CC(C)C1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CCC4[C@@]5(C)CC[C@H](c6cccc(C(=O)O)c6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,[Pd],CCOC(C)=O,,,,val
US20080188452A1,Cc1ccc(S(=O)(=O)Cl)cc1.Nc1nc(O)c2c(n1)-c1ccccc1CCCC2>>Cc1ccc(S(=O)(=O)Oc2nc(N)nc3c2CCCCc2ccccc2-3)cc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US04855085,C#C[C@@](C)(O)CCC1=C(C)C(=O)C(C)=C(C)C1=O.CC(=O)OC(C)=O>>C#C[C@](C)(CCC1=C(C)C(=O)C(C)=C(C)C1=O)OC(C)=O,,CCN(CC)CC,,,,val
US20070249597A1,CCN=C=O.Cc1nn(-c2ccccc2)c(N)c1C1=CCCCC1>>Cc1nn(-c2ccccc2)c2[nH]c(=O)c3c(c12)CCCC3,,c1ccncc1,,,,val
US20040214855A1,CCOC(=O)C(=O)CBr.N=C(Nc1ccc(Cl)cc1)c1ccccc1Cl>>CCOC(=O)C1(O)CN(c2ccc(Cl)cc2)C(c2ccccc2Cl)=N1,,CC(C)O,,O=C([O-])O.[Na+],,val
US06407120B1,CNC.O=C(O)c1ccc(NC(=O)C(c2ccccc2)c2ccccc2)cc1>>CN(C)C(=O)c1ccc(NC(=O)C(c2ccccc2)c2ccccc2)cc1,,ClC(Cl)Cl,ClCCl,ClCCCl,On1nnc2ccccc21,val
US20080167307A1,CC(C)(C)OC(=O)C(C)(C)Sc1nc(CC(=O)O)cs1.ClCCl.Nc1ccccn1.O=C(O)C(F)(F)F>>CCCCCCCN(CCc1csc(SC(C)(C)C(=O)O)n1)c1ccccn1,,ClCCl,,,,val
US20020010182A1,O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNC[C@H]1Cc1ccc(Cl)c(Cl)c1.O=[N+]([O-])c1ccc(CCl)cc1>>O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2ccc([N+](=O)[O-])cc2)C[C@H]1Cc1ccc(Cl)c(Cl)c1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20040092520A1,CNC1(C#N)CN(C(c2ccccc2)c2ccccc2)C1.O=S(=O)(O)O>>CNC1(C(N)=O)CN(C(c2ccccc2)c2ccccc2)C1,,ClCCl,,,,val
US20080280836A1,C=Cc1ccc(C2(O)COC(C)(C)OC2)cc1.C=Cc1ccc([C@@H]2[C@@H](CC[C@H](OC(C)=O)c3ccc(F)cc3)C(=O)N2c2ccc(OS(=O)(=O)C(F)(F)F)cc2)c(OCc2ccccc2)c1>>CC(=O)O[C@@H](CC[C@H]1C(=O)N(c2ccc(OS(=O)(=O)C(F)(F)F)cc2)[C@@H]1c1ccc(/C=C/c2ccc(C3(O)COC(C)(C)OC3)cc2)cc1OCc1ccccc1)c1ccc(F)cc1,,ClCCl,,,,val
US20050256104A1,CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)C(=O)NC1CCCNCC1O.O=S(=O)(Cl)c1ccccn1>>CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)C(=O)NC1CCCN(S(=O)(=O)c2ccccn2)CC1O,,ClCCl,,O,O=C([O-])O.[Na+],val
US20080194586A1,CCCc1nccc(Oc2ccc(Cl)cc2)c1C(=O)c1cc(OC)c(Cl)cc1F.CNN>>CCCc1nc(Oc2ccc(Cl)cc2)ccc1-c1nn(C)c2cc(Cl)c(OC)cc12,,CS(C)=O,,CCOC(C)=O,,val
US20020120144A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=Cc1ccc2[nH]ccc2c1>>Cc1ccc(S(=O)(=O)n2ccc3cc(C=O)ccc32)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20090143353A1,COc1c(F)c(I)c(C)c(C#N)c1NC(=O)C(C)(C)C.OB(O)c1ccccc1>>COc1c(F)c(-c2ccccc2)c(C)c(C#N)c1NC(=O)C(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,CN(C)C=O,,val
US20050049260A1,COc1ccc(-c2nn3c(NCCCCN)cccc3c2-c2ccnc(NC3CCCC3)n2)cc1.O=C1CCC(=O)O1>>COc1ccc(-c2nn3c(NCCCCNC(=O)CCC(=O)O)cccc3c2-c2ccnc(NC3CCCC3)n2)cc1,,ClCCl,,CCOCC,,val
US20030158185A1,NOS(=O)(=O)O.O=Cc1cc(F)c(Br)cc1F>>N#Cc1cc(F)c(Br)cc1F,,O,,,,val
US20090324581A1,COC(=O)c1ccc(C(F)(F)F)c(C2=CCCC2)c1>>COC(=O)c1ccc(C(F)(F)F)c(C2CCCC2)c1,[Pd],CO,,,,val
US20030186969A1,CCOC(C)=N.O=C(O)C(F)(F)F.O=C(c1ccc(Cl)cc1)N1CC(=O)N(CC2CCNCC2)c2ccccc2C1>>CC(=N)N1CCC(CN2C(=O)CN(C(=O)c3ccc(Cl)cc3)Cc3ccccc32)CC1.O=C(O)C(F)(F)F,,CCO,,CCN(CC)CC,Cl,val
US20030158198A1,CCCCC(=CC([Sn])CCCC)CCCC.Cc1cc2c(Br)cccc2cn1>>C=CCc1cccc2cnc(C)cc12,,CCOC(C)=O,Cc1ccccc1,,,val
US20060135578A1,CCOP(=O)(CCc1cn(-c2ccccc2)nc1O)OCC.COc1cc(CCl)ccc1OCc1nc(-c2ccco2)oc1C>>CCOP(=O)(CCc1cn(-c2ccccc2)nc1OCc1ccc(OCc2nc(-c3ccco3)oc2C)c(OC)c1)OCC,,O,,CN(C)C=O,[H-].[Na+],val
US20050143366A1,COc1cccc(O)c1C(N)=O.O=[N+]([O-])O>>COc1ccc([N+](=O)[O-])c(O)c1C(N)=O,,CC(=O)O,,,,val
US20100256156A1,COC(=O)c1cc(Br)oc1C.COc1ccccc1B(O)O>>COC(=O)c1cc(-c2ccccc2OC)oc1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20120259123A1,CCCCCCc1cccc(CC(NS(=O)(=O)c2ccccn2)c2cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)c1>>CCCCCCc1cccc(CC(NS(=O)(=O)c2ccccn2)c2cccc(NCC(=O)O)n2)c1,,ClCCl,,C1COCCO1,Cl,val
US20110009454A1,NCc1cccc(CCc2ccccc2)c1.Nc1ncccc1C(=O)O>>Nc1ncccc1C(=O)NCc1cccc(CCc2ccccc2)c1,,CN(C)C=O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20020077345A1,CCOC(=O)/C(F)=C(\CBr)C1(C(=O)OCC)CC1.C[C@H](N)c1ccccc1>>CCOC(=O)C1(C2=C(F)C(=O)N([C@@H](C)c3ccccc3)C2)CC1,,CCO,,O=C([O-])O.[Na+],,val
US06159967,CC(C)Oc1cccc(CC(=O)N2CCO[C@H](CCO)C2c2ccc(Cl)c(Cl)c2)c1.CS(=O)(=O)Cl>>CC(C)Oc1cccc(CC(=O)N2CCO[C@H](CCOS(C)(=O)=O)C2c2ccc(Cl)c(Cl)c2)c1,CN(C)c1ccncc1,c1ccncc1,,Cl,,val
US20100273792A1,CC(=O)OCBr.COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc4nc(-c5cc(OC)ccc5-c5ccc(Cl)cc5)ccc4c3)[nH]c2c1>>COC(=O)Cn1c(-c2ccc3nc(-c4cc(OC)ccc4-c4ccc(Cl)cc4)ccc3c2)c(C2CCCCC2)c2ccc(C(=O)OC)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20080261973A1,CS(=O)(=O)Nc1cccc(Nc2nc(Cl)c3nc[nH]c3n2)c1.NC1CCC1>>CS(=O)(=O)Nc1cccc(Nc2nc(NC3CCC3)c3nc[nH]c3n2)c1,,CCO,,CCN(CC)CC,,val
US20080090834A1,Cc1ccc(-n2cc(-c3cccs3)nc2-c2ccc(Nc3ncccc3[N+](=O)[O-])cc2)cn1>>Cc1ccc(-n2cc(-c3cccs3)nc2-c2ccc(Nc3ncccc3N)cc2)cn1,[Pd],CO,,[H][H],,val
US07579323B1,CC(C)[C@@H](C=O)N(C)C(=O)OC(C)(C)C.CCOC(=O)CC=P(c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)/C(C)=C/[C@H](C(C)C)N(C)C(=O)OC(C)(C)C,,ClCCl,O,,,val
US06262045B1,CCn1c2ccc(F)cc2c2c(C(=O)OC)nn(-c3ccccc3)c(=O)c21>>CCn1c2ccc(F)cc2c2c(CO)nn(-c3ccccc3)c(=O)c21,,C1CCOC1,CO,[BH4-].[Na+],,val
US03940421,CCCCCC(C)C(C)c1cc(O)cc(O)c1.CCOC(=O)C1CSCCC1=O>>CCCCCC(C)C(C)c1cc(O)c2c3c(c(=O)oc2c1)CSCC3,,CCO,,Cl,,val
US04259105,Nc1ccc(O)cc1.O=[N+]([O-])c1cc(C(F)(F)F)ccc1Cl>>O=[N+]([O-])c1cc(C(F)(F)F)ccc1Nc1ccc(O)cc1,,CC(C)O,,,,val
US04235923,CCCCCCC=C(C(=O)OCC)C(=O)OCC.OO>>CCCCCCC1OC1(C(=O)OCC)C(=O)OCC,,CO,,O=C([O-])O.[K+],,val
US20090221555A1,CCNC(=O)NNC(=O)c1ccccc1[N+](=O)[O-]>>CCNc1nnc(-c2ccccc2[N+](=O)[O-])o1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US04186132,CSC1C(=O)Nc2ccc([N+](=O)[O-])cc21.O=C1CCC(=O)N1Cl>>CSC1(Cl)C(=O)Nc2ccc([N+](=O)[O-])cc21,,ClC(Cl)Cl,,,,val
US20150299169A1,CC(C)(O)CCOc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1.Cl>>CC(C)(O)CCOc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1.Cl,,CC(C)=O,,,,val
US20070015784A1,CCC(CC)C(=O)N1CCC2(CC1)NC(=O)[C@H](Cc1ccccc1)N2.ClCc1ccccc1>>CCC(CC)C(=O)N1CCC2(CC1)N[C@@H](Cc1ccccc1)C(=O)N2Cc1ccccc1,,C1CCOC1,,Cl,[H-].[Na+],val
US05648367,Cl.Cl.NCCON.O=C(CCCn1ccnc1)c1ccc(F)cc1>>Cl.Cl.NCCON=C(CCCn1ccnc1)c1ccc(F)cc1,,CCO,,c1ccncc1,,val
US20020156081A1,COc1cc(-c2nn([C@@H]3CC[C@@H](N4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1N.O=C(Cl)CCc1ccccc1>>COc1cc(-c2nn([C@@H]3CC[C@@H](N4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)CCc1ccccc1,,c1ccncc1,,,,val
US20160002188A1,CC(C)(C)OC(=O)N1CCNCC1.Nc1cccc(-c2ccc(C(=O)O)cc2)c1>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccccc2-c2cccc(N)c2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20110288066A1,CCCCC=Cc1ccncc1Br>>CCCCCCc1ccncc1Br,O=[Pt]=O,CCOC(C)=O,,,,val
US20080090851A1,CCOC(=O)Cn1c(CCc2ccc(F)cc2F)nc(=O)c2cccnc21>>O=C(O)Cn1c(CCc2ccc(F)cc2F)nc(=O)c2cccnc21,,CCO,O,[Li+].[OH-],,val
US20120040020A1,CC(C)S(=O)(=O)N1CC2(CCN(C(=O)OCc3ccccc3)C2)C1>>CC(C)S(=O)(=O)N1CC2(CCNC2)C1,[Pd],CC(=O)O,ClCCl,,,val
US20110237588A1,CCI.Cc1[nH]nc(-c2ccc(Cl)s2)c1Br>>CCn1nc(-c2ccc(Cl)s2)c(Br)c1C,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US05612373,CC(C)(C)OC(=O)COc1ccc(C(=O)NNC(=O)C2CCN(C(=O)OC(C)(C)C)CC2)cc1OCC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C(O)COc1ccc(C(=O)NNC(=O)C2CCNCC2)cc1OCC(=O)O,,ClCCl,,,,val
US05284849,COC(=O)C(Cc1ccccc1)CS(=O)(=O)Cl.c1ccc(CN2CCNCC2)cc1>>COC(=O)C(Cc1ccccc1)CS(=O)(=O)N1CCN(Cc2ccccc2)CC1,,ClCCl,,[Na+].[OH-],,val
US20050272784A1,O=C(Cl)c1ccc(-c2ccccc2)cc1.[C-]#[N+]CC(=O)OC>>COC(=O)c1ncoc1-c1ccc(-c2ccccc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20100173793A1,COc1cccc(Br)c1.O=C(N1CCCCC1)C(F)(F)F>>COc1cccc(C(=O)C(F)(F)F)c1,,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US20120059015A1,C(#Cc1ccccc1)C1=NOC2(CCNCC2)C1.Cc1ccc([N+](=O)[O-])c(Cl)n1>>Cc1ccc([N+](=O)[O-])c(N2CCC3(CC2)CC(C#Cc2ccccc2)=NO3)n1,,CC(=O)N(C)C,,CCN(CC)CC,O,val
US20020156116A1,CC(C)CCC(=O)O.Cc1ccccc1N>>Cc1ccccc1NC(=O)CCC(C)C,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20130116262A1,Brc1cn2ccnc2c(Br)n1.CC(C)(C)OC(=O)N1CCN(c2ccc(N)nc2)CC1>>CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3nc(Br)cn4ccnc34)nc2)CC1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US06124323,Fc1ccc(OCCCBr)cc1.c1ccc(OC2CCNCC2)cc1>>Fc1ccc(OCCCN2CCC(Oc3ccccc3)CC2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100056542A1,COC(CN)OC.N#Cc1ccc(N=C=S)c2ccccc12>>N#Cc1ccc(-n2ccnc2S)c2ccccc12,,C1COCCO1,,Cl,,val
US06573288B1,CN(C)C=NS(=O)(=O)c1ccccc1S(=O)(=O)c1ccc(CBr)cc1.O=Cc1[nH]c(-c2ccccc2)nc1Cl>>CN(C)C=NS(=O)(=O)c1ccccc1S(=O)(=O)c1ccc(Cn2c(-c3ccccc3)nc(Cl)c2C=O)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US05166390,CC(=O)S/C=C\C(=O)Cl.NC1CCCCCCCCCCC1>>CC(=O)S/C=C\C(=O)NC1CCCCCCCCCCC1,,ClCCl,,CCN(CC)CC,O,val
US20130059835A1,COc1c(C(C)O)cc(C)c(C#N)c1C1CN(C(=O)OC(C)(C)C)C1.O=S(Cl)Cl>>COc1c(C(C)Cl)cc(C)c(C#N)c1C1CN(C(=O)OC(C)(C)C)C1,,CN(C)C=O,ClCCl,,,val
US20100105744A1,Cc1cccc2ccn(C(=O)OC(C)(C)C)c12.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)n1ccc2cccc(CBr)c21,,ClC(Cl)(Cl)Cl,,,,val
US05705654,C1=COCCC1.C1COCCO1.OCC1(O)COC(O)(CO)CO1>>O=C(COC1CCCCO1)COC1CCCCO1,,CCN(CC)CC,ClCCl,O=C([O-])O.[Na+],,val
US04381395,CN=C(NC#N)SC.O=C(OO)c1cccc(Cl)c1>>CN=C(NC#N)S(C)=O,,CC(C)=O,,,,val
US20140045862A1,CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@@H]2O[C@@H]2C1.Cn1cccn1>>Cn1nccc1[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@@H]1O,,C1CCOC1,,[Li]CCCC,,val
US20130085132A1,COc1ccc(CN2CC(C(=O)O)CC2=O)c(OC)c1.O=C1N[C@@H](Cc2ccccc2)CO1>>COc1ccc(CN2C[C@@H](C(=O)N3C(=O)OC[C@@H]3Cc3ccccc3)CC2=O)c(OC)c1,CN(C)c1ccncc1,ClC(Cl)Cl,,CCN=C=NCCCN(C)C,Cl,val
US20150232454A1,COc1cc(Cc2ccc(F)cc2)cnc1OC>>O=c1[nH]cc(Cc2ccc(F)cc2)cc1O,,ClCCl,,BrB(Br)Br,,val
US20070149533A1,CC(C)(C)OC(=O)n1cccc1B(O)O.Nc1cc(Br)cc(C(F)(F)F)c1>>CC(C)(C)OC(=O)n1cccc1-c1cc(N)cc(C(F)(F)F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US05849759,Cc1nc2cc(OC3CCN(C(=O)OC(C)(C)C)CC3)c(O)cc2n1Cc1ccc(C#N)c2ccccc12.O=C(OCc1ccccc1)N1CCC(O)CC1>>Cc1nc2cc(OC3CCN(C(=O)OC(C)(C)C)CC3)c(OC3CCN(C(=O)OCc4ccccc4)CC3)cc2n1Cc1ccc(C#N)c2ccccc12,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150126490A1,CN[C@H](C(=O)O)c1ccccc1>>CN[C@H](CO)c1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080287410A1,CC(C)(C)OC(=O)NC1CCC(CNc2nc(NC(Cc3ccccc3)c3ccccc3)ncc2[N+](=O)[O-])CC1>>N[C@@H]1CC[C@@H](CNc2nc(NC(Cc3ccccc3)c3ccccc3)ncc2[N+](=O)[O-])CC1,,C1COCCO1,,Cl,,val
US20060183762A1,CC(C)N.CCOC(=O)c1cc(F)c(N2CCC(NC(=O)OC(C)(C)C)C2)cc1F>>CCOC(=O)c1cc(F)c(N2CCC(NC(=O)OC(C)(C)C)C2)cc1NC(C)C,,CS(C)=O,,,,val
US20090247746A1,COC(=O)CSCc1sccc1S(=O)(=O)N(C)c1cccc2cc(-c3nccs3)[nH]c12>>CN(c1cccc2cc(-c3nccs3)[nH]c12)S(=O)(=O)c1ccsc1CSCC(=O)O,,C1CCOC1,CO,[Na+].[OH-],,val
US20090318690A1,BrC(Br)(Br)Br.CC(C)(C)[Si](OC[C@H]1C[C@H]1CO)(c1ccccc1)c1ccccc1>>CC(C)(C)[Si](OC[C@@H]1C[C@@H]1CBr)(c1ccccc1)c1ccccc1,,ClCCl,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140256706A1,CC(C)(C)[Si](C)(C)OCc1ccc(Br)c2ccccc12.CC(C)OB1OC(C)(C)C(C)(C)O1>>CC1(C)OB(c2ccc(CO[Si](C)(C)C(C)(C)C)c3ccccc23)OC1(C)C,,C1CCOC1,,[Li]CCCC,,val
US05750549,COC(=O)N(C)[C@H]1CC[C@H](N(Cc2ccc(OC)cc2)C(=O)OCc2ccccc2)[C@@H]1c1ccc(F)cc1>>COC(=O)N(C)[C@H]1CC[C@H](N)[C@@H]1c1ccc(F)cc1,[Pd],CO,,,,val
US20080214641A1,COc1ccc(F)c(C=NNc2ccc(F)cc2)c1>>COc1ccc2c(cnn2-c2ccc(F)cc2)c1,,CN1CCCC1=O,,CC(C)(C)[O-].[K+],,val
US20100087433A1,CC1(C)OB(c2cnn(CC(N)=O)c2)OC1(C)C.COc1ccc(CNc2cncc(Br)c2)cc1OC1CCCC1>>COc1ccc(CNc2cncc(-c3cnn(CC(N)=O)c3)c2)cc1OC1CCCC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,CC#N,O=C([O-])[O-].[Na+].[Na+],val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(Oc3ccccc3)c(C(=O)O)c2)=C(C)C1=O.COc1ccc(N)cc1>>COC1=C(OC)C(=O)C(Cc2ccc(Oc3ccccc3)c(C(=O)Nc3ccc(OC)cc3)c2)=C(C)C1=O,,ClCCl,,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US20080119539A1,CCCCCC(OCc1ccc(OC)cc1)c1ccc(N(CC#CCCCC(=O)OC)C(C)=O)cc1>>CCCCCC(O)c1ccc(N(CC#CCCCC(=O)OC)C(C)=O)cc1,,ClC(Cl)Cl,O,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20080015199A1,CC(C)(C)O.CCc1cc(OCC(=O)N(C)C)c(F)c(C(Nc2ccc(-c3noc(C)n3)cc2)c2nn(-c3ccccc3C(=O)O)c(=O)[nH]2)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCc1cc(OCC(=O)N(C)C)c(F)c(C(Nc2ccc(-c3noc(C)n3)cc2)c2nn(-c3ccccc3NC(=O)OC(C)(C)C)c(=O)[nH]2)c1,,O,,CCN(CC)CC,CCOC(C)=O,val
US20140024650A1,CCBr.O=C([O-])CCCO>>CCOC(=O)CCCO,,CN(C)C=O,,O,,val
US20100197716A1,CC1(C)CCN(c2ccccc2N)c2ccccc21.O=C(N=C=S)c1ccccc1>>CC1(C)CCN(c2ccccc2NC(=S)NC(=O)c2ccccc2)c2ccccc21,,ClCCl,,,,val
US20090186909A1,Cc1cccc(C)c1-c1cccc(CO)c1.N#Cc1ccc(Cl)nc1>>Cc1cccc(C)c1-c1cccc(COc2ccc(C#N)cn2)c1,,C1CCOC1,,[H-].[Na+],,val
US20070249637A1,COC(=O)[C@@H]1C[C@H](O)CN1C(=O)OC(C)(C)C.Oc1nc(-c2ccccn2)nc2ccsc12>>COC(=O)[C@@H]1C[C@@H](Oc2nc(-c3ccccn3)nc3ccsc23)CN1C(=O)OC(C)(C)C,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150284395A1,CCOC(=O)CC(=O)c1ccc(Cl)cc1.Cc1csc(-c2cn[nH]c2N)n1>>Cc1csc(-c2cnn3c(=O)cc(-c4ccc(Cl)cc4)[nH]c23)n1,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04870096,C=CC(=O)Cl.CCOC(=O)Cc1ccc(CN)cc1>>C=CC(=O)NCc1ccc(CC(=O)OCC)cc1,,ClCCl,,CCN(CC)CC,,val
US20120165318A1,COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N(C)C(C)C)nc2c1>>CC(C)N(C)c1nc2cc(C(=O)O)ccc2nc1-c1ccc(F)cc1,,CO,O,[Na+].[OH-],,val
US20140018345A1,Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(N)nc2c1-c1cccc(C(F)(F)F)c1.O=C(Cl)CCl>>Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(NC(=O)CCl)nc2c1-c1cccc(C(F)(F)F)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20090203737A1,N#Cc1ccc[nH]1.NO>>N=C(NO)c1ccc[nH]1,,CCO,,,,val
US20070281955A1,COc1cc(-c2nc3sccn3c2-c2ccnc(N[C@@H]3CCCNC3)n2)ccc1F.O=S(=O)(Cl)c1ccc(Cl)cc1>>COc1cc(-c2nc3sccn3c2-c2ccnc(N[C@@H]3CCCN(S(=O)(=O)c4ccc(Cl)cc4)C3)n2)ccc1F,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20140178374A1,O=Cc1ccccc1O.O=[N+]([O-])c1ccc2c(c1)Cc1ccccc1-2>>O=[N+]([O-])c1ccc2c(c1)C(=Cc1ccccc1O)c1ccccc1-2,,CO,,ClCCl,,val
US20150087663A1,O=C1CCC(=O)N1Cl.ON=Cc1c(Cl)ncnc1Cl>>ON=C(Cl)c1c(Cl)ncnc1Cl,,CCOC(C)=O,CN(C)C=O,,,val
US20140329876A1,Cc1c(C2=NN3CC[C@@H](O)[C@H]3[C@@H]2OC2CCCCO2)ccc(C#N)c1Cl>>Cc1c(C2=NN3CC[C@@H](O)[C@H]3[C@@H]2O)ccc(C#N)c1Cl,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090306082A1,COC(=O)c1ccc(OC)c2oc(C=O)cc12.O=C(O)CC(=O)O>>COC(=O)c1ccc(OC)c2oc(/C=C\C(=O)O)cc12,,Cc1ccccc1,,C1CCNCC1,Cl,val
US20040234958A1,CC=NO.Nc1ccc2[nH]nnc2c1.O=Cc1cccc2[nH]nnc12>>CC(=O)c1ccc2[nH]nnc2c1,,ClCCl,,,,val
US04966904,BrB(Br)Br.COc1cc(F)c(C2CNCc3sccc32)cc1OC>>Br.Oc1cc(F)c(C2CNCc3sccc32)cc1O,,ClCCl,,CO,,val
US07241317B2,CN1CCCNCC1.O=[N+]([O-])c1ccccc1F>>CN1CCCN(c2ccc([N+](=O)[O-])cc2)CC1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20070208017A1,COc1ccc2c(c1)-c1cc(Br)ccc1C(=O)C2=O>>O=C1C(=O)c2ccc(Br)cc2-c2cc(O)ccc21,,ClCCl,,BrB(Br)Br,,val
US20080269257A1,Cc1c(-c2ccncn2)nc2n(c1=O)CCCN2.O=C(CBr)c1ccccc1>>Cc1c(-c2ccncn2)nc2n(c1=O)CCCN2CC(=O)c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20080051418A1,CCCOc1cc(CCC(=O)OCC)[nH]n1.FC(F)(F)c1ccc(CBr)cc1>>CCCOc1cc(CCC(=O)OCC)n(Cc2ccc(C(F)(F)F)cc2)n1,,O,,CN(C)C=O,[H-].[Na+],val
US20090111859A1,COC(=O)CCc1ccc(OCc2ccc(C(C)(C)C)c(-c3cc(OC)ccc3F)c2)cc1>>COc1ccc(F)c(-c2cc(COc3ccc(CCC(=O)O)cc3)ccc2C(C)(C)C)c1,,C1CCOC1,CCO,[Li+].[OH-],,val
US20140228368A1,Cc1nc(Cl)cc(Cl)n1.Cn1cc(CN)cn1>>Cc1nc(Cl)cc(NCc2cnn(C)c2)n1,,C1COCCO1,CCOC(C)=O,CCN(CC)CC,,val
US05877204,Nc1ccc(C(=O)c2ccccc2)cc1.O=C1C=CC(=O)O1>>O=C(O)/C=C\C(=O)Nc1ccc(C(=O)c2ccccc2)cc1,,ClCCl,,,,val
US20160075647A1,CC1(C)O[C@H](c2ccc(-c3ccc(S(C)(=N)=O)nc3)cc2)[C@H](CF)N1C(=O)C(F)F>>CS(=N)(=O)c1ccc(-c2ccc([C@@H](O)[C@@H](CF)NC(=O)C(F)F)cc2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130225620A1,Cc1ccc(S(=O)(=O)n2ccc3ccc(CNc4nccc(Nc5cc(C6CC6)[nH]n5)n4)cc32)cc1>>c1cc(Nc2cc(C3CC3)[nH]n2)nc(NCc2ccc3cc[nH]c3c2)n1,,CO,O,[K+].[OH-],,val
US20050250822A1,CSc1ccc(C2=NOC(c3ccc(NC(=O)OC(C)(C)C)c(C)c3)(C(F)(F)F)C2)cc1.O=C(OO)c1cccc(Cl)c1>>Cc1cc(C2(C(F)(F)F)CC(c3ccc(S(C)=O)cc3)=NO2)ccc1NC(=O)OC(C)(C)C,,ClCCl,,,,val
US20100022775A1,O=C(O)[C@H](O)[C@@H](O)C(=O)O.OCCOc1cccc(CN2CC[C@@H](Nc3cccc4cnccc34)C2)c1>>O=C(O)[C@H](O)[C@@H](O)C(=O)O.OCCOc1cccc(CN2CC[C@@H](Nc3cccc4cnccc34)C2)c1,,CCO,,,,val
US20150175604A1,CI.Cc1nnc2ccc3c(cc(-c4ccn[nH]4)n3Cc3ccccc3)n12>>Cc1nnc2ccc3c(cc(-c4ccn(C)n4)n3Cc3ccccc3)n12,,CN(C)C=O,,[H-].[Na+],,val
US20130059834A1,C[Si](C)(C)CCOCn1cc(C(=O)O)c2nc(Br)cnc21.N[C@@H]1CCN(Cc2ccccc2)C1>>C[Si](C)(C)CCOCn1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c2nc(Br)cnc21,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040067983A1,C1CCOC1.CCOC(=O)C(CC#CC(=O)c1ccc(Br)cc1)c1cccc(C)c1.CCOC(C)=O.NN>>Cc1ccc(-n2nc(CC(C(=O)O)c3cccc(C)c3)cc2-c2ccc(Br)cc2)cc1,,C1CCOC1,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140187545A1,CCOC(=O)C(C#N)Cc1cccc(Cl)c1Cl>>N#CC(Cc1cccc(Cl)c1Cl)C(=O)O,,CO,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090054508A1,CCCS(=O)(=O)Cl.COc1c(OCCN)ccc(C(OC)OC)c1[N+](=O)[O-]>>CCC(CCOc1ccc(C=O)c([N+](=O)[O-])c1OC)S(N)(=O)=O,,C1CCOC1,,CCN(CC)CC,O,val
US20020049220A1,BrBr.CSC1=NC=CC(F)(CC(=O)c2ccccc2)N1>>CSC1=NC=CC(F)(C(Br)C(=O)c2ccccc2)N1,,CC(=O)O,,,,val
US05436134,C=C1CC(=O)O1.CNc1ccccc1>>Cc1cc(=O)n(C)c2ccccc12,,CCOC(C)=O,O,CC(=O)O,O=S(=O)(O)O,val
US20070232627A1,O=C(Nc1ccc(Sc2ccc(O)cc2)c([N+](=O)[O-])c1)c1ccccc1>>Nc1cc(NC(=O)c2ccccc2)ccc1Sc1ccc(O)cc1,[Fe],CC(=O)O,CCO,,,val
US20020103229A1,O=C(Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1)c1ccncc1>>Fc1ccc(-c2n[nH]c3ccc(NCc4ccncc4)cc23)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05244894,COC(=O)c1ccnc(NCCN2CCN(c3cc(Cl)ccc3OC)CC2)n1.NCCCNc1nc(=O)cc[nH]1>>COc1ccc(Cl)cc1N1CCN(CCNc2nccc(C(=O)NCCCNc3nc(=O)cc[nH]3)n2)CC1,,CCCCO,,,,val
US20110245353A1,CCOC(=O)c1cnc2ccc(OC)cc2c1Cl.N>>CCOC(=O)c1cnc2ccc(OC)cc2c1N,,CC(C)O,,,,val
US09186423B1,CC(=C(C#N)C#N)c1ccc2cc(N(C)CCOCCO)ccc2c1.CCN(CC)S(F)(F)F>>CC(=C(C#N)C#N)c1ccc2cc(N(C)CCOCCF)ccc2c1,,ClCCl,,,,val
US20130123268A1,CCN(CC)S(F)(F)F.O=C(c1csc(-c2cn[nH]c2)c1)N1C2CCC1CC(O)(c1ncccc1Cl)C2>>O=C(c1csc(-c2cn[nH]c2)c1)N1C2CCC1CC(F)(c1ncccc1Cl)C2,,ClCCl,,O=C([O-])O.[Na+],,val
US20090281103A1,C=CC[Sn](CCCC)(CCCC)CCCC.CC(C)(C)OC(=O)N(Cc1cc(Br)ccc1Cl)C1CC1>>C=CCc1ccc(Cl)c(CN(C(=O)OC(C)(C)C)C2CC2)c1,,C1CCOC1,,[Cs+].[F-],,val
US20030083335A1,COC(=O)c1cc(Cl)ccc1OC>>COc1ccc(Cl)cc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070249649A1,CC1(C)CC=C(c2cc(C(C)(C)CN3CC4OC(C)(C)OC4C3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1.Cl>>CC1(C)CC=C(c2cc(C(C)(C)CN3CC(O)C(O)C3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1.Cl,,CCOC(C)=O,,C1CCOC1,,val
US20120277240A1,CC(C)(C)OC(=O)N1Cc2c[nH]nc2C1.NC(=O)CI>>CC(C)(C)OC(=O)N1Cc2cn(CC(N)=O)nc2C1,,CC#N,,[H-].[Na+],,val
US04714698,C1CNCCN1.CCCSc1ncnc2c(N3CCCCC3)nc(Cl)nc12>>CCCSc1ncnc2c(N3CCCCC3)nc(N3CCNCC3)nc12,,CS(C)=O,,,,val
US20150175594A1,Nc1sc2c(c1-c1nc(C3CC3)ns1)CCC(F)(F)C2.O=C1OC(=O)C2=C1CCCC2>>O=C(O)C1=C(C(=O)Nc2sc3c(c2-c2nc(C4CC4)ns2)CCC(F)(F)C3)CCCC1,,CO,ClCCl,,,val
US04585789,O=C1OC(CCCOCc2ccccc2)C(c2ccccc2)=C1O>>O=C1OC(CCCO)C(c2ccccc2)=C1O,[Pd],CO,,,,val
US20150018547A1,COC(=O)Cc1csc2cc(OCc3ccc(C(F)(F)F)nc3C)cc(Cl)c12>>Cc1nc(C(F)(F)F)ccc1COc1cc(Cl)c2c(CC(=O)O)csc2c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20050148623A1,CC(C)(C)OC(=O)[C@@H](N1CCN(Cc2ccccc2F)C1=O)C(C)(C)C>>CC(C)(C)[C@@H](C(=O)O)N1CCN(Cc2ccccc2F)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110218201A1,COc1ccc(C2=NN(C3CCN(C(=O)c4ccccc4O)CC3)C(=O)C2(C)C)cc1OC.NC(=O)CCl>>COc1ccc(C2=NN(C3CCN(C(=O)c4ccccc4OCC(N)=O)CC3)C(=O)C2(C)C)cc1OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20070004772A1,CCCCBr.O=c1[nH]nc2c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)ccn12>>CCCCn1nc2c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)ccn2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100234395A1,CC(C)(C)c1ccc(C(=O)O)cc1.COC(=O)Cc1ccc(OC)cc1>>COC(=O)C(C(=O)c1ccc(C(C)(C)C)cc1)c1ccc(OC)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20070232583A1,Cc1cc(-c2ccc(Cl)cc2)nc(-n2cnc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)c2)n1>>Cc1cc(-c2ccc(Cl)cc2)nc(-n2cnc(-c3ccc(S(N)(=O)=O)cc3)c2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150158847A1,COc1ccc(COc2ccc(Cn3cnc4cc(C#N)cnc43)cc2OC)cn1.NO>>COc1ccc(COc2ccc(Cn3cnc4cc(C(N)=NO)cnc43)cc2OC)cn1,,CCO,,,,val
US20100298221A1,COC(=O)c1ccc(-c2ccc(C)c(F)c2)nc1Cl.COc1ccc(Cl)c(O)c1>>COC(=O)c1ccc(-c2ccc(C)c(F)c2)nc1Oc1cc(OC)ccc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020193596A1,COC(=O)[C@H](CCSC)NC(=O)c1ccc(C=O)cc1-c1ccccc1>>COC(=O)[C@H](CCSC)NC(=O)c1ccc(CO)cc1-c1ccccc1,,CCO,,[BH4-].[Na+],,val
US20110183938A1,CC(C)(C)OC(=O)N[C@H]1CCNC1.C[Si](C)(C)CCOCn1c2cnc(C#N)cc2c2c(Cl)ccnc21>>CC(C)(C)OC(=O)N[C@H]1CCN(c2ccnc3c2c2cc(C#N)ncc2n3COCC[Si](C)(C)C)C1,,CC(=O)N(C)C,CCOC(C)=O,,,val
US20110112140A1,O=[N+]([O-])c1cccc(Cc2ccco2)c1>>Nc1cccc(Cc2ccco2)c1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20030087924A1,CC(C)N=C(NC(C)C)OCc1ccccc1.Cc1sc(C(=O)O)cc1[N+](=O)[O-]>>Cc1sc(C(=O)OCc2ccccc2)cc1[N+](=O)[O-],,CC#N,,,,val
US20030096816A1,CCOC(=O)C(C#N)C(=O)C1CCCCC1>>N#CCC(=O)C1CCCCC1,,CS(C)=O,O,,,val
US20080119535A1,CCN(Cc1cnc[nH]1)c1cc(Cl)nc(Cc2ccccc2)n1>>CCN(Cc1cnc[nH]1)c1ccnc(Cc2ccccc2)n1,[Pd],CO,,O=C[O-].[NH4+],,val
US05554624,CCOC(=O)CC(=O)OCC.Cc1ccc(C=O)cc1>>CCOC(=O)C(=Cc1ccc(C)cc1)C(=O)OCC,,O,c1ccccc1,C1CCNCC1,,val
US20040220173A1,CC(C)(C)OC(=O)C1(CCN2CCN(c3csc4cc(C(F)(F)F)ccc34)CC2)CC1>>O=C(O)C1(CCN2CCN(c3csc4cc(C(F)(F)F)ccc34)CC2)CC1,,O=C(O)C(F)(F)F,,,,val
US20020107252A1,C[Si](C)(C)N=C=O.NC(=O)c1sc(-c2ccccc2)cc1N>>NC(=O)Nc1cc(-c2ccccc2)sc1C(N)=O,,CN(C)C=O,,ClCCl,,val
US20030119869A1,CC(C)(C)OC(=O)NC1CCN(CCC(c2ccccc2)c2ccccc2)CC1>>NC1CCN(CCC(c2ccccc2)c2ccccc2)CC1,,ClCCl,,Cc1ccccc1,O=C(O)C(F)(F)F,val
US20100144714A1,COC(=O)CCCn1c(=S)[nH]c2ccccc2c1=O.O=P(Cl)(Cl)Cl>>COC(=O)CCCn1c(Cl)nc2ccccc2c1=O,,O=P(Cl)(Cl)Cl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20090258854A1,O=C(Cl)C(=O)Cl.S=c1[nH]c2ccncc2s1>>Clc1nc2ccncc2s1,,ClCCCl,O,CN(C)C=O,O=C([O-])O.[Na+],val
US20120034270A1,CC(C)(C)OC(=O)NC1(C#Cc2ccc(OCCC3=CCC4CC3C4(C)C)cc2)COC(C)(C)OC1>>CC(C)(C)OC(=O)NC1(CCc2ccc(OCCC3=CCC4CC3C4(C)C)cc2)COC(C)(C)OC1,[Pd],CCO,,,,val
US20060100246A1,CC(C)(C)OC(=O)N1CCCC(c2cc(-c3c(OCc4ccccc4)cccc3OCc3ccccc3)nc(N)c2C#N)C1>>CC(C)(C)OC(=O)N1CCCC(c2cc(-c3c(O)cccc3O)nc(N)c2C#N)C1,[Pd],C1CCOC1,CCOC(C)=O,CC(=O)O,,val
US03979381,CCCNN.O=C1C(=Cc2ccc(Cl)c(Cl)c2)CSCC1=Cc1ccc(Cl)c(Cl)c1>>CCCN1N=C2C(=Cc3ccc(Cl)c(Cl)c3)CSCC2C1c1ccc(Cl)c(Cl)c1,,CO,ClC(Cl)Cl,,,val
US20050277689A1,COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12.C[C@H](O)C(=O)O>>CC(O)C(=O)[O-].COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12,,O,,CC(C)=O,,val
US20080119457A1,CCOC(=O)CC(C)=O.N#Cc1ccc(NN)cc1Br>>Cc1cc(O)n(-c2ccc(C#N)c(Br)c2)n1,,CC(=O)O,,,,val
US20090299072A1,BrCCCCBr.CCOC(=O)Cc1ccc([N+](=O)[O-])c(OCC(F)(F)F)c1>>CCOC(=O)C1(c2ccc([N+](=O)[O-])c(OCC(F)(F)F)c2)CCCC1,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20100267712A1,CI.CN(C)/C=N/c1ccc2[nH]ccc2n1>>CN(C)/C=N/c1ccc2c(ccn2C)n1,,O,,CN(C)C=O,[H-].[Na+],val
US20150322076A1,CC(C)(C#N)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C12C(=O)Nc1cc(Cl)ccc12.NC(=O)c1ccc(N)cc1>>CC(C)(C#N)CC1NC(C(=O)Nc2ccc(C(N)=O)cc2)C(c2cccc(Cl)c2F)C12C(=O)Nc1cc(Cl)ccc12,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20020198197A1,Cc1cc(-c2cccc(C(=O)CC(=O)Nc3cc(C#N)c(N4CCOCC4)cc3NC(=O)OC(C)(C)C)c2)on1>>Cc1cc(-c2cccc(C3=Nc4cc(N5CCOCC5)c(C#N)cc4NC(=O)C3)c2)on1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090203750A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)NC[C@@H]1C[C@H]1c1cccc(N)c1>>CC(=O)Nc1cccc([C@@H]2C[C@H]2CNC(=O)OC(C)(C)C)c1,CN(C)c1ccncc1,ClCCl,,,,val
US20150152113A1,FC(F)(F)c1c(N2CCC(c3ccccc3)CC2)cnnc1Cl.NN>>NNc1nncc(N2CCC(c3ccccc3)CC2)c1C(F)(F)F,,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US06514968B1,Cc1ccc2c(c1)c1c(O)cccc1n2Cc1ccccc1.N#CCBr>>Cc1ccc2c(c1)c1c(OCC#N)cccc1n2Cc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04210648,O=C1Nc2cccnc2N(C(=O)CCNCc2ccccc2)c2ccccc21>>NCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21,[Pd],CCO,,,,val
US20050250810A1,CC(C)(C)OC(=O)N1CCCc2cccnc21.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCCc2cc(Br)cnc21,,ClCCl,,CC(=O)O,,val
US20060094754A1,CC(=O)CC(=O)C(F)(F)F.Nc1ccc(OC(F)(F)F)cc1C(=O)c1ccc(F)c(F)c1>>Cc1nc2ccc(OC(F)(F)F)cc2c(-c2ccc(F)c(F)c2)c1C(=O)C(F)(F)F,,CCCCCCC,CCOC(C)=O,CC(C)O,,val
US20070072865A1,Nc1ccc(F)cc1.O=C(Cl)CCl.O=C1OC(c2ccccc2)(c2ccccc2)C2CNCCN12>>O=C(CNc1ccc(F)cc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1,,C1CCOC1,O,CCN(C(C)C)C(C)C,,val
US20160060273A1,CCOC(=O)C1(CC)CCN(C2=NOC3(C2)CN(Cc2cc(OCC)c(-c4ccc(F)cc4)c(C4CC4)c2)C3)CC1>>CCOc1cc(CN2CC3(CC(N4CCC(CC)(C(=O)O)CC4)=NO3)C2)cc(C2CC2)c1-c1ccc(F)cc1,,CO,,Cl,[Na+].[OH-],val
US06093838,CCCN(c1ccc(C(=O)OCC)cc1)c1ccc2c(c1)C(C)(C)OC2(C)C>>CCCN(c1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)OC2(C)C,,CCO,,[Na+].[OH-],,val
US05665777,CCOC(=O)CCCBr.Oc1ccc(-c2ccccc2)cc1>>CCOC(=O)CCCOc1ccc(-c2ccccc2)cc1,,CCOCC,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110065764A1,N[C@@H]1CCC[C@H](O)C1.O=C(Cl)c1noc(-c2ccc(F)c(F)c2)c1Cl>>O=C(N[C@@H]1CCC[C@H](O)C1)c1noc(-c2ccc(F)c(F)c2)c1Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150175628A1,CS/C(=N\C(=O)C(CCCCl)c1ccc(F)cc1)Nc1ccc(-c2nn3c(C)ncc3o2)cc1.NN>>Cc1ncc2oc(-c3ccc(Nc4n[nH]c(C(CCCCl)c5ccc(F)cc5)n4)cc3)nn12,,CCO,,O,,val
US20030130354A1,N#CC(=CC12CC3CC(CC(C3)C1)C2)c1ccccc1>>N#CC(CC12CC3CC(CC(C3)C1)C2)c1ccccc1,[Pd],CCOC(C)=O,,,,val
US20070032517A1,COC(=O)c1c(NC(C)=O)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2n(C)c1=O.N>>Cn1c(=O)c(C(N)=O)c(N)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc21,,C1CCOC1,CO,,,val
US20070259869A1,CCC(=O)Nc1ccc(S)cc1.CCOC(=O)Cc1cc(Nc2cc(C)[nH]n2)nc(Cl)n1>>CCOC(=O)Cc1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)CC)cc2)n1,,CC(C)(C)O,,CCOC(C)=O,,val
US04732978,ClCc1ccc2ccccc2n1.Oc1cccc(Br)c1>>Brc1cccc(OCc2ccc3ccccc3n2)c1,,CN(C)C=O,,[H-].[Na+],,val
US05420138,CCCCc1nn2ccccc2c1C(=O)c1ccc(Br)cc1.CN(C)C=O>>CCCCc1nn2ccccc2c1C(=O)c1ccccc1C#N,,O,,,,val
US20090192138A1,COc1cccc(C(=O)Cn2cnc3c(C(N)=O)c(N4CCC[C@@H](NC(=O)OC(C)(C)C)C4)n(CC=C(C)C)c3c2=O)c1>>COc1cccc(C(=O)Cn2cnc3c(C(N)=O)c(N4CCC[C@@H](N)C4)n(CC=C(C)C)c3c2=O)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110288090A1,COC(=O)C(=O)c1ccccc1.Nc1ccc(Cl)nc1N>>O=c1[nH]c2ccc(Cl)nc2nc1-c1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20150087644A1,Cc1nc2ccccc2nc1Cl.OCc1cccc(N2CCCC2)n1>>Cc1nc2ccccc2nc1OCc1cccc(N2CCCC2)n1,,CN(C)C=O,,O,[H-].[Na+],val
US20130225552A1,Clc1ncc2ccccc2n1.Cn1c(=O)n([C@H]2C[C@H](N)C2)c2ncc(F)cc21>>Cn1c(=O)n([C@@H]2C[C@@H](Nc3ncc4ccccc4n3)C2)c2ncc(F)cc21,,CS(C)=O,O,CCN(C(C)C)C(C)C,Cl,val
US20040009998A1,CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(Cc1ccccc1)C[C@H]2c1ccc(Br)cc1.C[Sn](C)(C)c1cncnc1>>CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(Cc1ccccc1)C[C@H]2c1ccc(-c2cncnc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US04012379,C=C1CC(=O)O1.Cc1ccc(SCC2=C(C(=O)O)N3C(=O)C(N)[C@H]3SC2)n[n+]1[O-]>>CC(=O)CC(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3ccc(C)[n+]([O-])n3)CS[C@H]12,,CC(C)=O,,O,O=C([O-])O.[Na+],val
US20070191395A1,CCOC(=O)C1CCCCC1=O.N#CCc1ncc[nH]1>>N#CC1CCc2c(cc3[nH]ccn3c2=O)C1,,O,,C,O=C[O-].[NH4+],val
US04929613,CCOC(=O)C(=CNC1CC1)C(=O)c1cc(F)c(C2CCN(C)CC2)cc1F>>CCOC(=O)c1cn(C2CC2)c2cc(C3CCN(C)CC3)c(F)cc2c1=O,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20080139606A1,NC(=O)c1[nH]c2ncccc2c1-c1ccc(N)cc1.O=C=Nc1cc(C(F)(F)F)ccc1F>>NC(=O)c1[nH]c2ncccc2c1-c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1,,C1CCOC1,,,,val
US20070208033A1,CCCN(CCC)Cc1ccc(N)cc1.O=C(O)c1ccc(CN(Cc2ncc[nH]2)Cc2ncc[nH]2)c2ccccc12>>CCCN(CCC)Cc1ccc(NC(=O)c2ccc(CN(Cc3ncc[nH]3)Cc3ncc[nH]3)c3ccccc23)cc1,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20080275069A1,CN.Cc1cccc(C(=O)O)c1N>>CNC(=O)c1cccc(C)c1N,,C1CCOC1,,,,val
US20110039843A1,CCc1cccnc1.OO>>CCc1ccc[n+]([O-])c1,,CC(=O)O,,O=C([O-])[O-].[Na+].[Na+],,val
US20150368210A1,CC(C)(C)OC(=O)N(Cc1c(Cl)cccc1Cl)c1nc(-c2ccc(CN3CCN(C(=O)OC(C)(C)C)C(C(=O)OC4CCCC4)C3)nc2)cnc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>Nc1ncc(-c2ccc(CN3CCNC(C(=O)OC4CCCC4)C3)nc2)nc1NCc1c(Cl)cccc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US06562954B1,CC(C)(C)C(=O)Cl.CC(CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CCC4CCCC[C@]4(C)[C@H]3CC[C@]12C)CO[C@@H]1O[C@H](CO)[C@H](OCc2ccccc2)[C@H](O)[C@H]1OCc1ccccc1>>CC(CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CCC4CCCC[C@]4(C)[C@H]3CC[C@]12C)CO[C@@H]1O[C@H](COC(=O)C(C)(C)C)[C@H](OCc2ccccc2)[C@H](O)[C@H]1OCc1ccccc1,,CCOC(C)=O,c1ccncc1,,,val
US20060106012A1,CS(=O)(=O)OC1CCN(Cc2ccccc2)C1.O=S(=O)(c1ccccc1)c1ccc2c(c1)OCCN2>>O=S(=O)(c1ccccc1)c1ccc2c(c1)OCCN2C1CCN(Cc2ccccc2)C1,,CN(C)C=O,,O,[H-].[Na+],val
US20140343038A1,CC1(O)CCC1.Cc1cc(Br)cc2cn[nH]c12>>Cc1cc(Br)cc2cn(C3(C)CCC3)nc12,,CCOC(C)=O,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20140315888A1,CC1(NC(=O)OC(C)(C)C)CN(c2nc3ncc(Br)cc3nc2Cl)C1.NN>>CC1(NC(=O)OC(C)(C)C)CN(c2nc3ncc(Br)cc3nc2NN)C1,,CCO,,O,,val
US05173485,CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccc4n3CCCN4)CS[C@H]12)c1csc(N)n1.O=S(=O)(O)O>>CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(C[n+]3ccc4n3CCCN4)CS[C@H]12)c1csc(N)n1.O=S(=O)([O-])O,,CCO,,,,val
US06018046,CC(C)(C)OC(=O)CBr.O=c1ccn2c3ccc(Br)cc3c3cc(O)cc1c32>>CC(C)(C)OC(=O)COc1cc2c(=O)ccn3c4ccc(Br)cc4c(c1)c23,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060040999A1,FC(F)(F)c1ccc(I)c(CBr)c1.O=C1NCC(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)O1>>O=C1OC(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CN1Cc1cc(C(F)(F)F)ccc1I,,C1CCOC1,,[H-].[Na+],,val
US20160122344A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCc3ccccc3)cc1CC2C(C)(C)COC>>COCC(C)(C)C1Cc2cc(OCc3ccccc3)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21,,C1CCOC1,CCO,Cl,[Li+].[OH-],val
US06576766B1,CCOP(=O)(OCC)c1cc(CCC(=O)OC)ccc1OCP(=O)(OC(C)C)OC(C)C>>CCOP(=O)(OCC)c1cc(CCC(=O)O)ccc1OCP(=O)(OC(C)C)OC(C)C,,C1CCOC1,O,[Li]O,,val
US06034055,CC(C)(C)OC(=O)NCC(=O)NCC(=O)O.CCCCCCCC/C=C\CCCCCCCC(=O)N(CCCCCCCCCCCCCC)[C@]1(N)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1C(=O)[C@H](C)N>>CCCCCCCC/C=C\CCCCCCCC(=O)N(CCCCCCCCCCCCCC)[C@]1(N)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1C(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)OC(C)(C)C,,C1CCOC1,,,,val
US04981962,CC(=O)OC(C)=O.O=C1c2cc(C(F)(F)F)c(C(F)(F)F)cc2C(=O)c2cc3ccccc3cc21>>CC(=O)Oc1c2cc(C(F)(F)F)c(C(F)(F)F)cc2c(OC(C)=O)c2cc3ccccc3cc12,[Pd],CCOC(C)=O,,CC(=O)[O-].[K+],,val
US20110251186A1,CCOCCl.Oc1ccc(Br)cc1Br>>COCOc1ccc(Br)cc1Br,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100063054A1,CCn1cc(-c2ccc(NN)nc2)ccc1=O.S=C=Nc1ccccc1>>CCn1cc(-c2ccc3nnc(S)n3c2)ccc1=O,,CN1CCCC1=O,ClCCl,,,val
US20070032470A1,COc1cccc(CN(C[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(NC(=O)c3ccccc3)cc(C(C)=O)c2)C(=O)OC(C)(C)C)c1.NO>>COc1cccc(CN(C[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(NC(=O)c3ccccc3)cc(/C(C)=N/O)c2)C(=O)OC(C)(C)C)c1,,CCO,,Cl,,val
US20090042872A1,O=Cc1ccc(OC2CCCCO2)cc1OCc1ccccc1Br>>O=Cc1ccc(O)cc1OCc1ccccc1Br,,CCO,,CCCCCC,,val
US05708008,CN1CCC(c2c[nH]c3ccc(N)cc23)CC1.COC(=O)Cl>>COC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2c1,,ClCCl,,,,val
US20120088767A1,Cc1nc2c(C(=O)O)cc(N3CCOCC3)cc2n1Cc1cccc2ccccc12>>Cc1nc2c(CO)cc(N3CCOCC3)cc2n1Cc1cccc2ccccc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110212918A1,CC(C)c1cccnc1N.O=[N+]([O-])O>>CC(C)c1cc([N+](=O)[O-])cnc1O,,O=S(=O)(O)O,,O,,val
US05981576,CC(C)I.CC1(C)OC(=O)C(O)=C1c1ccc(S(C)(=O)=O)cc1>>CC(C)OC1=C(c2ccc(S(C)(=O)=O)cc2)C(C)(C)OC1=O,,c1ccccc1,,,,val
US20110028493A1,CCOC(=O)c1cnn(Cc2nc(-c3cccc([N+](=O)[O-])c3)cs2)c1>>CCOC(=O)c1cnn(Cc2nc(-c3cccc(N)c3)cs2)c1,[Pd],C1CCOC1,CCO,,,val
US20060166983A1,COC(=O)C(=O)c1c[nH]c2cc(OCc3ccccc3)ccc12>>COC(=O)Cc1c[nH]c2cc(O)ccc12,[Pd],C1COCCO1,,,,val
US20060106048A1,CCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccc(C(=O)OC)c(N(Cc3ccc4ccccc4n3)C(=O)C(F)(F)F)c1)=NC(C)(C)C2>>CCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccc(C(=O)OC)c(NCc3ccc4ccccc4n3)c1)=NC(C)(C)C2,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20160159774A1,C=CC(=O)N1CCC[C@@H](Nc2nc(Nc3ccc4c(c3)CNC4)ncc2F)C1.O=C1CCOCC1>>C=CC(=O)N1CCC[C@@H](Nc2nc(Nc3ccc4c(c3)CN(C3CCOCC3)C4)ncc2F)C1,,CO,,[BH3-]C#N.[Na+],,val
US20150175594A1,COC(=O)C1=C(C(=O)O)CC(C)(C)C1.Nc1sc2c(c1-c1nc(C3CC3)no1)CCCC2>>COC(=O)C1=C(C(=O)Nc2sc3c(c2-c2nc(C4CC4)no2)CCCC3)CC(C)(C)C1,,ClCCl,O=S(Cl)Cl,CCN(C(C)C)C(C)C,CN(C)C=O,val
US20150329489A1,CC(=O)O.N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C12CC3CC(CC(O)(C3)C1)C2>>CC(=O)[O-].N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C12CC3CC(CC(O)(C3)C1)C2,,CC(=O)O,,CC(C)O,,val
US20040180929A1,CC(C)(C)OC(=O)OC(C)(C)C.Clc1ccc(C2=CCNCC2)cc1>>CC(C)(C)OC(=O)N1CC=C(c2ccc(Cl)cc2)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US20130190303A1,COc1ccc(CCBr)cc1.Cc1ccc(NN)cc1>>COc1ccc(N(N)c2ccc(C)cc2)cc1,,CCO,,CCN(CC)CC,Cl,val
US07189850B2,N#CC1(Nc2ccc(F)cc2)CCN(Cc2ccccc2)CC1.O>>NC(=O)C1(Nc2ccc(F)cc2)CCN(Cc2ccccc2)CC1,,O,,O=S(=O)(O)O,[Na+].[OH-],val
US20090118305A1,Nc1nccnc1-c1nc2ccc(F)cc2o1.O=C1CCC(=O)N1Br>>Nc1ncc(Br)nc1-c1nc2ccc(F)cc2o1,,CCOC(C)=O,,CN(C)C=O,,val
US04959361,C#CCn1c(=O)n(-c2ccccc2)c2ccccc21.Cc1nnc2n1-c1sc(I)cc1C(c1ccccc1Cl)=NC2>>Cc1nnc2n1-c1sc(C#CCn3c(=O)n(-c4ccccc4)c4ccccc43)cc1C(c1ccccc1Cl)=NC2,,ClCCl,,CCO,,val
US05290948,NC(c1ccccc1)c1ccccc1.O=C[C@H](O)[C@@H](O)[C@H](O)C(=O)CO>>OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1C(c1ccccc1)c1ccccc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20120289506A1,CCOC(=O)c1ccc(-n2cc(C#N)c(-c3ccccc3O)c2)cc1OCOC.COCCCBr>>CCOC(=O)c1ccc(-n2cc(C#N)c(-c3ccccc3OCCOC)c2)cc1OCOC,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110201605A1,CC(C)(C)OC(=O)N1CCC(Nc2nc3c(-c4ccc(F)cc4Cl)cccn3n2)CC1>>Fc1ccc(-c2cccn3nc(NC4CCNCC4)nc23)c(Cl)c1,,C1CCOC1,CO,Cl,,val
US20100137338A1,Cn1ncc(Cl)c1-c1ccc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)cc1F>>Cn1ncc(Cl)c1-c1ccc(C(=O)N[C@H](CN)Cc2ccccc2C(F)(F)F)cc1F,,C1CCOC1,CO,NN,,val
US20120202803A1,CC#CCBr.COC(=O)c1ccc(O)cn1>>CC#CCOc1ccc(C(=O)OC)nc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110009547A1,CCCCCCCC[Si](C)(C)Cl.O>>CCCCCCCC[Si](C)(C)O,,CCOCC,,CCN(CC)CC,,val
US20120245136A1,CI.COc1cc(C(=O)N2CCC3(CC2)CC(O)c2ccccc2O3)ccc1OC(C)C>>COc1cc(C(=O)N2CCC3(CC2)CC(OC)c2ccccc2O3)ccc1OC(C)C,,C1CCOC1,,[H-].[Na+],,val
US06166006,CI.Cc1ccccc1-c1cccc(/C=C/C(=O)Nc2ccc(CN3CCCCC3)cc2)c1>>Cc1ccccc1-c1cccc(/C=C/C(=O)Nc2ccc(C[N+]3(C)CCCCC3)cc2)c1.[I-],,CN(C)C=O,,,,val
US20110306607A1,CC(=O)OCc1ccc2c(c1)OC1(CCN(C(=O)OC(C)(C)C)CC1)c1ccc(C#N)n1-2>>CC(=O)OCc1ccc2c(c1)OC1(CCNCC1)c1ccc(C#N)n1-2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090325985A1,COC(=O)c1ncn(-c2ncc(OC)c3cc[nH]c23)n1>>COc1cnc(-n2cnc(CO)n2)c2[nH]ccc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20010053851A1,Nc1nccs1.O=C(O)C(CC1CCCC1)c1ccc(C#CC2(O)CCCCC2)cc1>>O=C(Nc1nccs1)C(CC1CCCC1)c1ccc(C#CC2(O)CCCCC2)cc1,,ClCCl,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20100112090A1,CCOC(=O)c1cncnc1Cl.Nc1cc(S(=O)(=O)N2CCCc3ccccc32)ccc1Cl>>CCOC(=O)c1cncnc1Nc1cc(S(=O)(=O)N2CCCc3ccccc32)ccc1Cl,,CN1CCCC1=O,,Cl,[H-].[Na+],val
US20070219198A1,N#Cc1cccnc1Cl.O=S(=O)(c1cccc(Cl)c1)C1CCNCC1>>N#Cc1cccnc1N1CCC(S(=O)(=O)c2cccc(Cl)c2)CC1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20090075979A1,CCOC(=O)C[C@@H]1CC[C@@H](CN(CC)c2cccnc2C=O)CC1>>CCOC(=O)C[C@@H]1CC[C@@H](CN(CC)c2cccnc2CO)CC1,,CCO,O,[BH4-].[Na+],,val
US20160222028A1,COC(=O)c1ccc2c(c1)OC[C@@H](C(C)C)N(C(C)=O)C2.NO>>CC(=O)N1Cc2ccc(C(=O)NO)cc2OC[C@H]1C(C)C,,C1CCOC1,CO,[Na+].[OH-],,val
US20020193382A1,Cl.O=C1CN(S(=O)(=O)C2=Cc3ccc(Cl)cc3OC2)CCN1CC1CCN(c2ccncc2)CC1>>Cl.O=C1CN(S(=O)(=O)C2=Cc3ccc(Cl)cc3OC2)CCN1CC1CCN(c2ccncc2)CC1,,CCOC(C)=O,,,,val
US20100324010A1,CC(C)CN(C(=O)c1ccc(C(F)(F)F)cc1N)C1CCCN(C(=O)OC(C)(C)C)C1.O=Cc1ccco1>>CC(C)CN(C(=O)c1ccc(C(F)(F)F)cc1NCc1ccco1)C1CCCNC1,,CC(=O)O,,O=C([O-])O.[Na+],,val
US20070032502A1,O=S(Cl)Cl.O=c1[nH]c(CN2CCN(Cc3ccccc3)CC2)nc2ccccc12>>Clc1nc(CN2CCN(Cc3ccccc3)CC2)nc2ccccc12,,ClCCl,,CN(C)C=O,,val
US20050234065A1,CC(C)(C)OC(=O)N[C@H](C(=O)O)[C@@H]1CC[C@H](O)CC1.CI>>COC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H]1CC[C@H](O)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150210682A1,C#CC(=O)OC.CCCOc1ccc(CCN)cc1OCCC>>CCCOc1ccc(CCNC=CC(=O)OC)cc1OCCC,,ClCCl,,,,val
US20040143136A1,CC1(C)CC(=O)O1.[Na+].[OH-]>>CC(C)(O)CC(=O)[O-].[Na+],,O,,,,val
US04416687,CNC(=O)CCl.Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CNC(=O)COc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CC(C)=O,,O,[K+].[OH-],val
US20120149691A1,N#Cc1cnn2cccc2c1Cl.NC1CCCC1>>N#Cc1cnn2cccc2c1NC1CCCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130345120A1,CC(C)(C)OC(=O)C1CCN(C(=O)OCc2ccccc2)N1C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)C1CCNN1,[Pd],CO,,N#N,,val
US04680293,NCCCCn1ccnc1.O=c1[nH]c2ccccc2c(=O)o1>>Nc1ccccc1C(=O)NCCCCn1ccnc1,,CCO,,,,val
US20110152273A1,COC(=O)c1c(C#N)cc(Cl)nc1Nc1cccc(C)c1.N[C@@H]1CCCC(F)(F)[C@@H]1N>>COC(=O)c1c(C#N)cc(N[C@@H]2CCCC(F)(F)[C@@H]2N)nc1Nc1cccc(C)c1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,Cl,val
US20100160303A1,CC(C)COC(=O)c1cccc2c(Br)cccc12.Fc1ccc([Mg]Br)cc1>>O=C(c1ccc(F)cc1)c1cccc2c(Br)cccc12,,C1CCOC1,,CCOCC,Cl,val
US20030187014A1,CCOC(=O)c1cnc2c(c(C)nn2-c2ccccn2)c1O>>Cc1nn(-c2ccccn2)c2ncc(C(=O)O)c(O)c12,,Cl,,[Na+].[OH-],,val
US04711895,C[Si](C)(C)OS(=O)(=O)C(F)(F)F.O=C1C=CC(O)(CCCCOc2ccccc2)C1>>C[Si](C)(C)OC1(CCCCOc2ccccc2)C=CC(=O)C1,,CCN(C(C)C)C(C)C,,CCOCC,O,val
US05436264,CS(=O)(=O)Cl.OCCOc1ccccc1OCC1CC1>>CS(=O)(=O)OCCOc1ccccc1OCC1CC1,,ClCCl,,CCN(CC)CC,O,val
US20040152598A1,Nc1ccc(C(C(F)(F)F)C(F)(F)F)nc1.O=C1CCC(=O)N1Cl>>Nc1ccc(C(C(F)(F)F)C(F)(F)F)nc1Cl,,CC#N,,,,val
US20050239780A1,COC(=O)Cc1c(C)nc2[nH]c3ccccc3c2c1C>>Cc1nc2[nH]c3ccccc3c2c(C)c1CC(=O)O,,CO,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US20140121197A1,CNN.O=C(c1cccnc1)c1c(Cl)nnc(-c2ccccc2)c1Cl>>Cn1nc(-c2cccnc2)c2c(Cl)c(-c3ccccc3)nnc21,,CCO,,,,val
US20080070866A1,CC(C)(C)OC(=O)N1C(C)(C)OC[C@]1(C)c1nnc(-c2ccc(OCCCCO)c(C(F)(F)F)c2)s1.NNC(=O)c1ccccc1>>C[C@](N)(CO)c1nnc(-c2ccc(OCCCCOCc3ccccc3)c(C(F)(F)F)c2)s1,,CC#N,O,,,val
US20050014765A1,CC(O[Si](C)(C)C(C)(C)C)n1ccc(C(=O)N2CCN(c3cccc(C(N)=O)c3)CC2)c1-c1ccccc1>>CC(O)n1ccc(C(=O)N2CCN(c3cccc(C(N)=O)c3)CC2)c1-c1ccccc1,,C1CCOC1,,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20070208064A1,CON(C)C(=O)c1cnc(S)n1-c1ccc(C)cc1>>Cc1ccc(-n2c(C=O)cnc2S)cc1,,C1CCOC1,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20020006937A1,CCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(C#CCO)sc21>>CCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCCO)sc21,[Pd],CO,ClCCl,,,val
US20090264431A1,CC(C)(C)OC(=O)N1C[C@H](NS(=O)(=O)c2cc(Br)ccc2Br)C[C@@H]1CO.CCN(CC)CC.O=C=Nc1ccc(C(F)(F)F)cc1>>CC(C)(C)NC(=O)OC[C@H]1C[C@@H](NS(=O)(=O)c2cc(Br)ccc2Br)CN1C(=O)OC(C)(C)C,,ClCCl,,,,val
US20110311461A1,CCOC(=O)c1cccc(NC(C(=O)O[C@H]2CN3CCC2CC3)c2ccc(OC)nc2)c1.O=C(CCl)c1ccccc1>>CCOC(=O)c1cccc(NC(C(=O)O[C@H]2C[N+]3(CC(=O)c4ccccc4)CCC2CC3)c2ccc(OC)nc2)c1.[Cl-],,CCOC(C)=O,,,,val
US04831151,CCc1n(N)cc[n+]1NCc1ccc(N(C)C)cc1.CN(C)c1ccc(C=O)cc1.[Cl-]>>CCc1n(N=Cc2ccc(N(C)C)cc2)cc[n+]1NCc1ccc(N(C)C)cc1.[Cl-],,CC(=O)O,,,,val
US20070037816A1,COC(=O)c1cccc(C(=O)OC)n1.Cl>>COC(=O)[C@@H]1CCC[C@H](C(=O)OC)N1.Cl,,CO,,,,val
US20090264445A1,CC(C)(C)OC(=O)C[C@H]1C[C@@H](Cn2ccc([N+](=O)[O-])n2)OC(C)(C)O1>>CC(C)(C)OC(=O)C[C@H]1C[C@@H](Cn2ccc(N)n2)OC(C)(C)O1,[Pd],CCO,,[H][H],,val
US06320081B1,C=CCOc1c(F)c(OCc2ccccc2)c(F)c(F)c1[N+](=O)[O-]>>C=CCOc1c(F)c(O)c(F)c(F)c1[N+](=O)[O-],,O=C(O)C(F)(F)F,,,,val
US07157487B2,CC(C)(C)OC(=O)C(C(=O)OC(C)(C)C)c1ccc([N+](=O)[O-])c(OCc2ccccc2)c1F>>O=C(O)Cc1ccc([N+](=O)[O-])c(O)c1F,,CC(=O)O,,Cl,,val
US05064825,CCCCc1nc(N)c(C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCCCc1nc(N)c(C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,CC(=O)O,,,,val
US20080096921A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1CCl.COC(=O)c1cc2ccc(-c3ccc(O)cc3)cc2cn1>>COC(=O)c1cc2ccc(-c3ccc(OCc4c(-c5ccccc5Cl)noc4C(C)C)cc3)cc2cn1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US03952046,CCCCCC(=O)Cl.N#Cc1ccc(-c2ccc(O)cc2)cc1>>CCCCCC(=O)Oc1ccc(-c2ccc(C#N)cc2)cc1,,c1ccccc1,,c1ccncc1,,val
US20100048568A1,Cc1cn(N)c2ccc(C(F)(F)F)cc12.Cc1nc(-c2ccccn2)ncc1C(=O)O>>Cc1nc(-c2ccccn2)ncc1C(=O)Nn1cc(C)c2cc(C(F)(F)F)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130079323A1,CCc1[nH]c2nc(Nc3cnc4c(c3)nnn4C(C)C)nc(N3CC(NC(=O)OC(C)(C)C)C3)c2c1Br>>CCc1[nH]c2nc(Nc3cnc4c(c3)nnn4C(C)C)nc(N3CC(N)C3)c2c1Br,,O=C(O)C(F)(F)F,,,,val
US20120232051A1,CNc1cnccc1N1CCCCC1C.O=C(Cl)c1cc(Cl)cc(Cl)c1>>CC1CCCCN1c1ccncc1N(C)C(=O)c1cc(Cl)cc(Cl)c1,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20090163534A1,COC(=O)Cc1c(C)c(Sc2ccc(S(C)(=O)=O)cc2)n2ccc(Cl)cc12>>Cc1c(CC(=O)O)c2cc(Cl)ccn2c1Sc1ccc(S(C)(=O)=O)cc1,,O,,C1CCOC1,[Li+].[OH-],val
US20110257179A1,COc1ccc(Cn2cc(-c3csc(Nc4ncccn4)n3)cn2)cc1.O=C1CCC(=O)N1Cl>>COc1ccc(Cn2cc(-c3nc(Nc4ncccn4)sc3Cl)cn2)cc1,,CN(C)C=O,,,,val
US20110269965A1,CCCc1nc(C#N)c(N)n1CCOCCNC(=O)OC(C)(C)C.ICI>>CCCc1nc(C#N)c(I)n1CCOCCNC(=O)OC(C)(C)C,,ClC(Cl)Cl,,CC(C)CCON=O,,val
US20070072893A1,CC1(CCCN)OCCO1.O=[N+]([O-])c1cnc2ccccc2c1Cl>>CC1(CCCNc2c([N+](=O)[O-])cnc3ccccc23)OCCO1,,ClCCl,,CCN(CC)CC,,val
US05919814,COc1cccc2c1OCC=C2>>COc1cccc2c1OCCC2,[Pd],CC(=O)O,,[H][H],,val
US20040192767A1,Cc1oc(C#N)cc1C(O[SiH2]C(C)(C)C)(c1ccccc1)c1ccccc1>>Cc1oc(C#N)cc1CO,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20160272597A1,O=C(n1ccnc1)n1ccnc1.O=C1c2ccccc2C(=O)N1C[C@H](O)CNc1ccc(F)c(F)c1>>O=C1c2ccccc2C(=O)N1C[C@H]1CN(c2ccc(F)c(F)c2)C(=O)O1,,CCOC(C)=O,,,,val
US20140221344A1,CC1CCC(NC(=O)OC(C)(C)C)CN1c1ccncc1[N+](=O)[O-]>>CC1CCC(NC(=O)OC(C)(C)C)CN1c1ccncc1N,[Pd],CCO,,,,val
US20080207721A1,O=C(Sc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccccc1>>Fc1ccc(-n2ncc3cc(S)ccc32)cc1,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US20040180893A1,CC(C)OC(=O)C(NC(=O)OCc1ccccc1)OC(C)C.N>>CC(C)OC(N)C(=O)NC(=O)OCc1ccccc1,,CCO,,,,val
US20070099903A1,COC(=O)[C@@H]1CCCN1C1CCN(C(=O)[C@@H](Cc2cc(C)c3[nH]c(=O)oc3c2)OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)CC1>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCC[C@H]3C(=O)O)CC2)cc2oc(=O)[nH]c12,,C1CCOC1,O,[Li+].[OH-],,val
US20100249163A1,COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(O)c2ccc(OCc3ccccc3)nc2)C2CC2)cc(OCCOC)c1>>COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(O)c2ccc(O)nc2)C2CC2)cc(OCCOC)c1,[Pd],CCOC(C)=O,,CC(=O)O,,val
US20040242572A1,C[Si](C)(C)C#Cc1cc(CC#N)ccc1CN1CCCC1>>CCc1cc(CCN)ccc1CN1CCCC1,[Ni],N,,,,val
US20150368247A1,C[C@@H](Nc1nc(Cl)nc2ncn(C[C@@H]3CC[C@@H](CI)CC3)c12)C1CCC1>>C=C1CCC(Cn2cnc3nc(Cl)nc(N[C@H](C)C4CCC4)c32)CC1,,COCCOC,,CC(C)(C)[O-].[K+],,val
US20050096337A1,CC(=O)c1ccc(OC(F)(F)F)cc1.CCOC(=O)C(F)(F)F>>O=C(/C=C(\O)C(F)(F)F)c1ccc(OC(F)(F)F)cc1,,Cc1ccccc1,,O=S(=O)(O)O,,val
US20110319430A1,CC1=NN(C)C(=O)C1.N#Cc1cc(F)c(F)c(F)c1>>Cc1cc(Oc2c(F)cc(C#N)cc2F)n(C)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030078249A1,COC(=O)c1ccc(OC(C)(C)CN)cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1ccc(OC(C)(C)CNC(=O)C(F)(F)F)cc1,,ClCCl,,CCN(CC)CC,O,val
US06124283,CN1CCN(c2cccc3c2CC2(CC3)OCCO2)CC1>>CN1CCN(c2cccc3c2CC(=O)CC3)CC1,,C1CCOC1,,Cl,,val
US20050054658A1,CS(=O)(=O)Cl.OC1CCC(OCCc2ccccc2)C(F)C1>>CS(=O)(=O)OC1CCC(OCCc2ccccc2)C(F)C1,,CCCCCC,CCOC(C)=O,CCN(C(C)C)C(C)C,ClCCl,val
US20150111869A1,Brc1ccc(Br)nc1.CCC(C)CC(=O)N(C)OC>>CCC(C)CC(=O)c1ccc(Br)cn1,,Cc1ccccc1,,[Li]CCCC,,val
US20140038976A1,CCOc1ccc(S(=O)(=O)N2CCN3C(=O)c4ccc(C)nc4C3C2)cc1.CI>>CCOc1ccc(S(=O)(=O)N2CCN3C(=O)c4ccc(C)nc4C3(C)C2)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05834506,O=C1C=C(O)C[C@@](CCc2cccc(OCc3ccccc3)c2)(C2CCCC2)O1>>O=C1C=C(O)C[C@@](CCc2cccc(O)c2)(C2CCCC2)O1,[Pd],C1CCOC1,,C,,val
US20120302566A1,CCOC(=O)C(F)(F)F.O=C(O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Br)cccc43)ccc21>>O=C(O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(C(=O)C(F)(F)F)cccc43)ccc21,,C1CCOC1,,CCOCC,[Li]CCCC,val
US20100310512A1,CC(C)(C)OC(=O)N1CCCC1c1ncc(-c2ccc(-c3ccc(-c4cnc(C5CCCN5)[nH]4)cc3)cc2)[nH]1.COC(CCC(F)(F)F)(N=C=O)C(=O)O>>COC(=O)NC(CCC(F)(F)F)C(=O)N1CCCC1c1ncc(-c2ccc(-c3ccc(-c4cnc(C5CCCN5C(=O)OC(C)(C)C)[nH]4)cc3)cc2)[nH]1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020193599A1,CCC1=CC(=O)OC(C)(C)O1.CN>>CCC(=O)CC(=O)NC,,Cc1ccccc1C,,Cl,,val
US20030060460A1,CC(C)I.COC(=O)c1ccc(COc2ccc(Cl)cc2NS(=O)(=O)c2ccccc2)cc1>>COC(=O)c1ccc(COc2ccc(Cl)cc2N(C(C)C)S(=O)(=O)c2ccccc2)cc1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20080009530A1,COCCOc1ccc(CCCN)c(Oc2ncc(C(F)(F)F)cc2Cl)c1.O=S(=O)(Cl)C1CCCCC1>>COCCOc1ccc(CCCNS(=O)(=O)C2CCCCC2)c(Oc2ncc(C(F)(F)F)cc2Cl)c1,,CCOC(C)=O,,Cl,c1ccncc1,val
US20040067938A1,O=C(Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1)c1ccc(CCl)cc1.c1ccncc1>>O=C(Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1)c1ccc(Cc2ccccn2)cc1,,c1ccncc1,,,,val
US20090163534A1,COC(=O)C(=O)Cl.Cc1cc2cc(Cl)ccn2c1Sc1ccc(S(C)(=O)=O)cc1>>COC(=O)C(=O)c1c(C)c(Sc2ccc(S(C)(=O)=O)cc2)n2ccc(Cl)cc12,,C1CCOC1,,,,val
US20020161237A1,COC(=O)C(NC(=O)c1ccc(C(O)/C=C/c2cccc(O)c2)cc1Cl)P(=O)(OC)OC.Cc1nc(C)c(C=O)s1>>COC(=O)/C(=C/c1sc(C)nc1C)NC(=O)c1ccc(C(O)/C=C/c2cccc(O)c2)cc1Cl,,C1CCOC1,,CN(C)C(=N)N(C)C,,val
US04229438,C[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)OC(C)(C)C>>C[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)O,,O=C(O)C(F)(F)F,,,,val
US20100035898A1,NC1CCC(CNc2ccccc2)CC1.O=C(Cl)c1cccc(Cl)c1>>O=C(N[C@@H]1CC[C@@H](CNc2ccccc2)CC1)c1cccc(Cl)c1,,ClCCl,,,,val
US20060287341A1,Cc1ccc(C(C)(C)O)cc1.O=C1CCC(=O)N1Br>>CC(C)(O)c1ccc(CBr)cc1,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,CCOC(C)=O,O,val
US20120071523A1,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.O=C(c1ccccc1)c1coc2ccc(O)cc12>>O=C1C=Cc2occ(C(=O)c3ccccc3)c2C1=O,,CS(C)=O,,CO,ClC(Cl)Cl,val
US20070219195A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)n1nc(Br)c2ccc(N)cc2c1=O>>CC(C)n1nc(Br)c2ccc(NC(=O)OC(C)(C)C)cc2c1=O,,CN(C)C=O,,O,[H-].[Na+],val
US20050014749A1,C=C(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2N.Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)O)cc1>>C=C(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)CC1C(=O)NCCN1S(=O)(=O)c1ccc(C)cc1,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US20090099169A1,CO[C@@H]1CC[C@@H](N)CC1.Cc1cc(C(=O)Cl)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12>>CO[C@@H]1CC[C@@H](NC(=O)c2cc(C)n(Cc3cc(Cl)cc4cc(C(C)C)oc34)n2)CC1,,ClCCl,,CCN(CC)CC,,val
US04582842,O=C(O)c1ccc([N+](=O)[O-])cc1SSc1cc([N+](=O)[O-])ccc1C(=O)O>>O=[N+]([O-])c1ccc(CO)c(S)c1,,C1CCOC1,,,,val
US20110028445A1,C=C1CCN(C=O)C(Cc2cccc(OC)c2)C1(C)C>>CC12CCNC(Cc3cccc(O)c31)C2(C)C,,O,,Br,,val
US05449783,Cc1ccc(-c2nc(N)sc2-c2ccccc2)cc1.O=S(=O)(O)C(F)(F)F>>Cc1ccc(-c2nc(NS(=O)(=O)C(F)(F)F)sc2-c2ccccc2)cc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US04654343,CC(=O)N(C)c1cccc(-c2ccc(Cl)nn2)c1.CCNC(=S)NN>>CCNc1nnc2ccc(-c3cccc(N(C)C(C)=O)c3)nn12,,CCO,,,,val
US20050250761A1,COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=CCCl.FC1CCCNC1>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=CCN1CCCC(F)C1,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,Cl,val
US20120129811A1,Cn1cnc2c(N=C=S)cccc21.N#Cc1ccc(N)c(OC(F)(F)F)c1>>Cn1cnc2c(NC(=S)Nc3ccc(C#N)cc3OC(F)(F)F)cccc21,,CN(C)C=O,,[H-].[Na+],,val
US04942163,CNC(C)N(C)C.Cc1ccc2cc(-c3cccc4ccccc34)nc(Cl)c2c1>>Cc1ccc2cc(-c3cccc4ccccc34)nc(N(C)CCN(C)C)c2c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20140329807A1,FC(F)(F)Oc1cccc(-c2cnc3ccc(Cl)nn23)c1.OCC1CCOCC1>>FC(F)(F)Oc1cccc(-c2cnc3ccc(OCC4CCOCC4)nn23)c1,,C1COCCO1,,CC(C)(C)[O-].[K+],,val
US20070219229A1,Brc1ncc(Br)c2[nH]ccc12.CI>>Cn1ccc2c(Br)ncc(Br)c21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050267095A1,CC(CCCl)N1CCCC1.N#CC1(c2ccc(O)cc2)CCOCC1>>CC(CCOc1ccc(C2(C#N)CCOCC2)cc1)N1CCCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120040981A1,Cc1[nH]ncc1-c1cc2c(s1)C(=O)NC1(CCC(O[Si](C)(C)C(C)(C)C)CC1)N2>>Cc1[nH]ncc1-c1cc2c(s1)C(=O)NC1(CCC(O)CC1)N2,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20060235029A1,CCN(CC)CCCNc1nc(-c2cccc(C(=O)O)c2)c2ccc(=O)n(-c3c(F)cccc3F)c2n1.NC1CC1>>CCN(CC)CCCNc1nc(-c2cccc(C(=O)NC3CC3)c2)c2ccc(=O)n(-c3c(F)cccc3F)c2n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150133446A1,BrCc1cccc(OCc2ccccc2)c1.COc1cc(O)c2oc(-c3cn4nc(OC)sc4n3)cc2c1>>COc1cc(OCc2cccc(OCc3ccccc3)c2)c2oc(-c3cn4nc(OC)sc4n3)cc2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050261290A1,CC(C)(O)CN1CCCC1C(=O)NC1CCCCC1.CI>>COC(C)(C)CN1CCCC1C(=O)NC1CCCCC1,,C1CCOC1,,[H-].[Na+],,val
US20130059853A1,CCOc1ccc(-c2ccc3c(c2)CCC3=O)c(OCOC)c1OC>>CCOc1ccc(-c2cccc3c2CCC3=O)c(O)c1OC,,CO,,Cl,,val
US20120202794A1,CC(C)C[C@H](N)C(N)=O.O=Cc1ccccc1>>CC(C)C[C@@H]1NC(c2ccccc2)NC1=O,,CCO,,CCN(CC)CC,O=C([O-])[O-].[K+].[K+],val
US20150105317A1,C[C@@H]1O[C@@H](OCCNC(=O)CCCCC(=O)NCCCC[C@H](NC(=O)OCc2ccccc2)C(=O)O)[C@@H](O)[C@H](O)[C@@H]1O>>C[C@@H]1O[C@@H](OCCNC(=O)CCCCC(=O)NCCCC[C@H](N)C(=O)O)[C@@H](O)[C@H](O)[C@@H]1O,,O,,,,val
US20070224130A1,CC1(CC(O)(CO)C(F)(F)F)CCCc2ccccc21>>CC1(CC(O)(C=O)C(F)(F)F)CCCc2ccccc21,,CS(C)=O,ClCCl,CCN(CC)CC,[Cl-].[NH4+],val
US20120122764A1,CC(C)(C)OC(=O)N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)c1nnnn1CCC#N>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)c1nnn[nH]1,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US20040029932A1,CC(=O)O.COc1ccc(F)cc1C(C)(C)CC(O)(Cc1ccc(C=O)cc1Cl)C(F)(F)F.NO>>COc1ccc(F)cc1C(C)(C)CC(O)(Cc1ccc(C(C)=NO)cc1Cl)C(F)(F)F,,CC(=O)O,,CCO,Cl,val
US20040162331A1,COc1ccc(Cl)c(I)c1>>Oc1ccc(Cl)c(I)c1,,ClCCl,,Cl,O=C([O-])O.[Na+],val
US04125544,CC(C)CCCO[C@H]1CC[C@H]2[C@@H]3C(=O)C=C4CCCC[C@]4(C)[C@H]3CC[C@]12C.O>>CC(C)CCCO[C@H]1CC[C@H]2[C@@H]3C(=O)C=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C,,O,,C1CCOC1,,val
US20090176786A1,CNc1cc(F)c(SC(F)(F)F)cc1F.O=C=NC(=O)c1c(F)cccc1F>>CN(C(=O)NC(=O)c1c(F)cccc1F)c1cc(F)c(SC(F)(F)F)cc1F,,CCOCC,,CCCCCC,,val
US05840732,Cl.O=C1SC(=CCCc2ccccc2Cl)C(=O)N1CCCCSc1cccc2nccn12>>Cl.O=C1SC(=CCCc2ccccc2Cl)C(=O)N1CCCCSc1cccc2nccn12,,CO,,CCOC(C)=O,,val
US20080207728A1,C#CCO.COC(=O)c1cc(I)ccc1O.Cc1ccccc1>>C#CC(C)Oc1ccc(I)cc1C(=O)OC,,Cc1ccccc1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05039693,CCc1nn(C)c(C(=O)NCc2ccc(Oc3ccc(C)cc3)cc2)c1Cl.NCc1ccc(Sc2ccccc2)cc1>>CCc1nn(C)c(C(=O)NCc2ccc(Sc3ccccc3)cc2)c1Cl,,O,,CCN(CC)CC,CCOC(C)=O,val
US20160152613A1,CC1(C)OC(=O)C(=Cc2cc(Cl)ccc2Br)C(=O)O1.NC1=CC(=O)CC1>>O=C1CC(c2cc(Cl)ccc2Br)C2=C(CCC2=O)N1,,C1COCCO1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120295882A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.O=C1COc2cc(I)ccc21>>CC(C)(C)OC(=O)N1CCc2c(oc3cc(I)ccc23)C1,,ClC(Cl)Cl,,Cl,,val
US20020173490A1,CCOP(=O)(CC(F)(F)C(CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)OC(=S)Oc1ccccc1)OCC>>CCOP(=O)(CC(F)(F)CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)OCC,,Cc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US04416683,CC#N.CCC(C)(CC)C(=O)OC>>CCC(C)(CC)C(=O)CC#N,,C1CCOC1,,[H-].[Na+],,val
US20110319439A1,COc1cc(Br)ccc1OCC(=O)C1CC1>>COc1cc(Br)ccc1OCC(O)C1CC1,,C1CCOC1,,CO,[BH4-].[Na+],val
US20140336106A1,C=O.COC(=O)C(CCN)C[C@H](NC(=O)OC(C)(C)C)C(=O)OC>>CNCCC(C[C@H](NC(=O)OC(C)(C)C)C(=O)OC)C(=O)OC,[Pd],CO,,,,val
US20050004119A1,BrCc1ccncc1.CC(C)N>>CC(C)NCc1ccncc1,,C1CCOC1,CCO,,,val
US04362887,C=CC(=O)OC(CSCc1ccccc1)CSCc1ccccc1.CCCCCCCCCCCCS>>CCCCCCCCCCCCSCCC(=O)OC(CSCc1ccccc1)CSCc1ccccc1,,CCO,,O,,val
US20130210858A1,COC(=O)c1ccc(S(=O)(=O)N(Cc2ccc3occc3c2)c2ncc(C(F)(F)F)cc2Cl)cc1>>O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc3occc3c2)c2ncc(C(F)(F)F)cc2Cl)cc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20050043309A1,Clc1cccc(N2CCN(CCCOc3ccc4ccc(OCc5ccccc5)nc4n3)CC2)c1Cl>>O=c1ccc2ccc(OCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nc2[nH]1,[Pd],CO,,,,val
US20020032227A1,CON=C(C#N)c1ccccc1CBr.Oc1cccc(Cl)c1>>CON=C(C#N)c1ccccc1COc1cccc(Cl)c1,,CN(C)C=O,,CCOCC,O=C([O-])[O-].[K+].[K+],val
US20130005730A1,CC(C)COC(=O)Cl.COCCCOc1cc(C[C@@H](C[C@@H]2NCO[C@H]2C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)ccc1OC>>COCCCOc1cc(C[C@@H](C[C@H]2[C@H](C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)OCN2C(=O)OCC(C)C)C(C)C)ccc1OC,CN(C)c1ccncc1,ClCCl,,,,val
US20100130545A1,CNCCCN(C)CCC1(O)CC2CCC1C=C2c1ccccc1.COCC(C)(COC)C(=O)O>>COCC(C)(COC)C(=O)N(C)CCCN(C)CC[C@]1(O)C[C@H]2CC[C@@H]1C=C2c1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140121198A1,CS(=O)(=O)Cl.C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CN)OC1>>C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CNS(C)(=O)=O)OC1,,CO,,CCN(C(C)C)C(C)C,,val
US05368641,Cc1ccc(Nc2cc(C(=O)O)c(Nc3ccc(C)cc3)cc2C(=O)O)cc1.O=C(O)c1cc(Nc2ccccc2)c(C(=O)O)cc1Nc1ccccc1>>O=c1c2ccccc2[nH]c2cc3c(=O)c4ccccc4[nH]c3cc12,,O,,,,val
US20100267774A1,C#CC(=O)O.CC(=O)OCCc1cc(F)c(NC(N)=CC(=O)c2ccc(F)cc2F)c(F)c1>>CC(=O)OCCc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20140256805A1,COCO[C@H]1CC[C@]2(C)[C@H](CC[C@@H]3C[C@]4(C)C(C#N)=CC[C@@H]4C[C@H]32)C1>>C[C@]12C[C@H]3CC[C@@H]4C[C@@H](O)CC[C@@]4(C)[C@@H]3C[C@H]1CC=C2C#N,,CO,ClCCl,Cl,,val
US20140256734A1,CC(C)(C)OC(=O)N1CC[C@H](Oc2nc(C#N)cc3ccc(Cl)cc23)C1.NN>>CC(C)(C)OC(=O)N1CC[C@H](Oc2nc(C(=N)NN)cc3ccc(Cl)cc23)C1,,CO,,O,,val
US20090247522A1,C1CC(N2CCOCC2)CCN1.C=CCOc1cc(OCC=C)c(C(=O)c2ccc(OCCCl)c(OC)c2)c(CC(=O)N(CCOC)CCOC)c1CC>>C=CCOc1cc(OCC=C)c(C(=O)c2ccc(OCCN3CCC(N4CCOCC4)CC3)c(OC)c2)c(CC(=O)N(CCOC)CCOC)c1CC,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20120046255A1,CCC(=O)c1ccc(OC)c(OC(C)C)c1>>CCC(=O)c1ccc(OC)c(O)c1,,CCCCCC,CCOC(C)=O,,,val
US20110257196A1,CON(C)C(=O)c1cccc(-c2ccccc2)c1.COc1cc([Mg]Br)cc(OC)c1OC>>COc1cc(C(=O)c2cccc(-c3ccccc3)c2)cc(OC)c1OC,,C1CCOC1,,,,val
US20040171634A1,C[Si](C)(C)CCOCN1CN(I)c2ccccc21.C[Si](C)(C)CCOCn1nc([Sn](C)(C)C)c2ccc([N+](=O)[O-])cc21>>C[Si](C)(C)CCOCn1nc(-c2nc3ccccc3n2COCC[Si](C)(C)C)c2ccc([N+](=O)[O-])cc21,[Cu]I,C1CCOC1,,,,val
US20080293665A1,CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2c(-c3cccnc3)nc3c(N)ncnc32)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C>>Nc1ncnc2c1nc(-c1cccnc1)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130296320A1,CCNc1cc(-c2nccc3c(-n4cnc(-c5cnn(C)c5)c4)ccnc23)ccc1C#N.OO>>CCNc1cc(-c2nccc3c(-n4cnc(-c5cnn(C)c5)c4)ccnc23)ccc1C(N)=O,,CS(C)=O,,O,[Na+].[OH-],val
US20080090834A1,Cc1ccc(N=C(N)c2ccc(I)cc2)cn1.Cc1csc(C(=O)CBr)n1>>Cc1ccc(-n2cc(-c3nc(C)cs3)nc2-c2ccc(I)cc2)cn1,,CC(C)O,,O=C([O-])O.[Na+],,val
US20150368265A1,CNC(=O)c1c(C(=O)OC)oc2cc(N(C)S(C)(=O)=O)c(Br)cc12.NN>>CNC(=O)c1c(C(=O)NN)oc2cc(N(C)S(C)(=O)=O)c(Br)cc12,,CCO,,O,,val
US03936465,BrCCCc1ccc2c(c1)CCC2.C1CCNCC1>>c1cc2c(cc1CCCN1CCCCC1)CCC2,,CCOCC,Cc1ccccc1,,,val
US20150232428A1,CC(C)(C)OC(=O)N1CCC(Oc2ccnc(Cl)n2)CC1.Cc1cc(N)cc(-c2ccccc2)c1.Cc1ccc(S(=O)(=O)O)cc1>>Cc1cc(Nc2nccc(OC3CCNCC3)n2)cc(-c2ccccc2)c1.Cc1ccc(S(=O)(=O)[O-])cc1,,C1COCCO1,,,,val
US05859007,Cc1ccc(N(C(=O)CBr)C(C)C)cc1.O=C1CC(=O)N(c2ccccc2)c2ccccc2N1>>Cc1ccc(N(C(=O)CN2C(=O)CC(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20110301176A1,CC(C)C[C@H](CO)N(CC1(NC(=O)OCc2ccccc2)CC1)C(=O)OC(C)(C)C>>CC(C)C[C@@H]1CN(C(=O)OCc2ccccc2)C2(CC2)CN1C(=O)OC(C)(C)C,,Cc1ccccc1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06242443B1,CC(=O)OC(C)=O.CC(C)NC1=NS(=O)(=O)c2cc(N)ccc2N1>>CC(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(NC(C)C)N2,,C1COCCO1,,O,,val
US20060111342A1,O=C(Cl)OCC(Cl)(Cl)Cl.c1ccc(CN2CCC(=C3c4ccccc4Oc4ccccc43)CC2)cc1>>O=C(OCC(Cl)(Cl)Cl)N1CCC(=C2c3ccccc3Oc3ccccc32)CC1,,ClC(Cl)Cl,,CC#N,O,val
US20110136780A1,Cc1ccc(S(=O)(=O)n2cc3c4c(c(F)cnc42)CN([C@@H](C(=O)OC(C)(C)C)C(C)C)C3=O)cc1>>CC(C)[C@H](C(=O)OC(C)(C)C)N1Cc2c(F)cnc3[nH]cc(c23)C1=O,,CO,,[Na+].[OH-],,val
US20090131458A1,COc1nc2c(N)nc(OCCC3CC3)nc2n1C1CCCCO1.O=C(O)C(F)(F)F>>COc1nc2c(N)nc(OCCC3CC3)nc2[nH]1.O=C(O)C(F)(F)F,,CO,,CCOC(C)=O,,val
US20140179667A1,Cc1cc(C)c(CCl)c(OCc2ccccc2)n1.O=C(OC[C@H]1C[C@@H](Oc2cc(Cl)c3c(c2Cl)C(=O)NCC3)CO1)c1ccc([N+](=O)[O-])cc1>>Cc1cc(C)c(CN2CCc3c(Cl)cc(O[C@H]4CO[C@@H](CO)C4)c(Cl)c3C2=O)c(OCc2ccccc2)n1,,CCOC(C)=O,CN(C)C=O,C1CCOC1,CC(C)(C)[O-].[K+],val
US08304419B2,C[Si](C)(C)CCOCn1cnc(Cl)c1C(=O)O.Cc1cc(C#N)cc(Oc2c(Cl)ccc(CN)c2F)c1>>Cc1cc(C#N)cc(Oc2c(Cl)ccc(CNC(=O)c3[nH]cnc3Cl)c2F)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140005164A1,COC(=O)[C@@H]1CC[C@@H](Cn2c(=O)n(C)c3ccc(=O)[nH]c32)CC1.COc1cccc(CBr)c1>>COC(=O)[C@@H]1CC[C@@H](Cn2c(=O)n(C)c3ccc(OCc4cccc(OC)c4)nc32)CC1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080114006A1,CN.CSc1ncc2cc(-c3cc(NC(=O)Nc4cnn(C(C)(C)C)c4C(F)(F)F)c(F)cc3C)c(=O)n(C)c2n1>>CNc1ncc2cc(-c3cc(NC(=O)Nc4cnn(C(C)(C)C)c4C(F)(F)F)c(F)cc3C)c(=O)n(C)c2n1,,C1CCOC1,,O=C(OO)c1cccc(Cl)c1,,val
US03962282,CC(C)=CCCC(C)=CCCc1ccc2c(c1)OCO2>>CC(C)CCCC(C)CCCc1ccc2c(c1)OCO2,[Pd],c1ccccc1,,[H][H],,val
US20020173646A1,CC(=O)Oc1cc(N)ccc1C.COc1cc2c(Cl)ncnc2cc1OCc1ccccc1>>COc1cc2c(Nc3ccc(C)c(OC(C)=O)c3)ncnc2cc1OCc1ccccc1,,CC(C)O,,,,val
US20060258690A1,CC(C)(C)Cn1c(CBr)cc2cnc(C#N)nc21.CC(C)(C)OC(=O)N1CCC2(CC1)CC(=O)NC2=O>>CC(C)(C)Cn1c(CN2C(=O)CC3(CCN(C(=O)OC(C)(C)C)CC3)C2=O)cc2cnc(C#N)nc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100113424A1,COCN(Cc1ccccc1)C[Si](C)(C)C.O=[N+]([O-])/C=C/c1ccc(Cl)c(F)c1>>O=[N+]([O-])C1CN(Cc2ccccc2)CC1c1ccc(Cl)c(F)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150291636A1,CC(C)[Si](OC[C@@H](OCc1ccccc1)[C@H](OCc1ccccc1)[C@@H](CNOCc1ccccc1)OCc1ccccc1)(C(C)C)C(C)C.O=CO>>CC(C)[Si](OC[C@@H](OCc1ccccc1)[C@H](OCc1ccccc1)[C@@H](CN(C=O)OCc1ccccc1)OCc1ccccc1)(C(C)C)C(C)C,,C1CCOC1,O,O=C(n1ccnc1)n1ccnc1,,val
US20040116509A1,C=CCC(CC(=C)C)C(=O)OCC>>CCOC(=O)C1CC=C(C)C1,,ClCCl,,,,val
US20140275104A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CC=O)CC1.CC(C)(C)c1nc(C2CCC2)cc(N2CCNCC2)n1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CCN2CCN(c3cc(C4CCC4)nc(C(C)(C)C)n3)CC2)CC1,,ClCCCl,O,CC(=O)O,[Na],val
US20150299125A1,Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc([C@](C)(O)[C@@H]3CC[C@@H](C(=O)OCOC(=O)OCCCCCCNC(=O)OC(C)(C)C)CC3)nc2)c1>>Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc([C@](C)(O)[C@@H]3CC[C@@H](C(=O)OCOC(=O)OCCCCCCN)CC3)nc2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130116235A1,Cn1cc(-c2ccnc(-n3ncc4c5n(cc4c3=O)CCCC5)c2C=O)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O>>Cn1cc(-c2ccnc(-n3ncc4c5n(cc4c3=O)CCCC5)c2CO)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O,,CO,,[BH4-].[Na+],,val
US20080207616A1,COC(=O)c1cc([N+](=O)[O-])cc(C(C)(C)C#N)c1>>COC(=O)c1cc(N)cc(C(C)(C)C#N)c1,[Pd],CO,,,,val
US07211586B2,CCOC(=O)CC(C)c1ccc2c(c1)CCNC2C(=O)Cc1cc(C)c2nc(Nc3ccccc3C)oc2c1>>Cc1ccccc1Nc1nc2c(C)cc(CC(=O)C3NCCc4cc(C(C)CC(=O)O)ccc43)cc2o1,,CCO,,[Na+].[OH-],,val
US20140336185A1,CCCCCCCOc1ccc(C(=O)Oc2ccc(CN(CC(=O)OC(C)(C)C)C(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1>>CCCCCCCOc1ccc(C(=O)Oc2ccc(CN(CC(=O)OC(C)(C)C)C(=O)c3ccc(N)cc3)cc2)cc1,[Pd],C1CCOC1,,,,val
US20060194780A1,CSCC1(C2CCCCC2)CC2CCC(C1)N2C(=O)[C@H]1C[NH+](C(C)(C)C)C[C@H]1c1ccc(F)cc1F.O.[Cl-]>>CS(=O)CC1(C2CCCCC2)CC2CCC(C1)N2C(=O)[C@H]1C[NH+](C(C)(C)C)C[C@H]1c1ccc(F)cc1F.[Cl-],,CCOCC,O,CCO,Cl,val
US20130225561A1,N#Cc1ccc2c(c1)OCCC2C=O.O=C1OCc2cc(CCN3CCNCC3)ccc21>>N#Cc1ccc2c(c1)OCCC2CN1CCN(CCc2ccc3c(c2)COC3=O)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20060025474A1,CCC(CC)(c1ccc(O)c(C)c1)c1ccc(/C=C/C(OCOC)(C(F)(F)F)C(F)(F)F)c(C)c1.CCOC(=O)CCCCCBr>>CCOC(=O)CCCCCOc1ccc(C(CC)(CC)c2ccc(/C=C/C(OCOC)(C(F)(F)F)C(F)(F)F)c(C)c2)cc1C,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090048230A1,C=CCOC(=O)c1cnc(Cl)nc1Cl.CNCC1CCC2(CC1)CC2>>C=CCOC(=O)c1cnc(Cl)nc1N(C)CC1CCC2(CC1)CC2,,C1COCCO1,,CCN(CC)CC,,val
US04713387,O=S(Cl)Cl.OCCCc1ccc(Cc2cccnc2)cc1>>Cl.ClCCCc1ccc(Cc2cccnc2)cc1,,ClCCl,,,,val
US20070225318A1,CC(C)(C)OC(=O)N1CCc2ncc(NC(=O)c3cc[nH]n3)cc2C1>>O=C(Nc1cnc2c(c1)CNCC2)c1cc[nH]n1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20090170927A1,COC(=O)C(C)Oc1ccc(OC(C)C(=O)OC)cc1>>CC(Oc1ccc(OC(C)C(=O)O)cc1)C(=O)O,,Cl,,,,val
US20050203172A1,CC(C)(C)OC(=O)N1[C@@H](CC(=O)OCc2ccccc2)COC1(C)C>>CC(C)(C)OC(=O)N1[C@@H](CC(=O)O)COC1(C)C,[Pd],CCO,,[H][H],,val
US20130261077A1,CC(=O)OC[C@H]1O[C@H](c2cccc(O[Si](C)(C)C(C)(C)C)c2)[C@@H](O)[C@@H](O)[C@@H]1OC(C)=O.FCCI>>OC[C@H]1O[C@H](c2cccc(OCCF)c2)[C@@H](O)[C@@H](O)[C@@H]1O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070213337A1,CCCc1ccc(C(=O)N(CC)CC)cc1.CSSC>>CCCc1ccc(C(=O)N(CC)CC)c(SC)c1,,C1CCOC1,,[Li]C(C)CC,,val
US05661162,CC(C)(C)OC(=O)N1CCC(CS(=O)(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1.Cl>>Cl.O=S(=O)(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC1(c2ccccc2)CCNCC1,,CCOCC,,,,val
US20070232645A1,Cc1ccc(OS(=O)(=O)C(F)(F)F)c([N+](=O)[O-])c1.Sc1ccccn1>>Cc1ccc(Sc2ccccn2)c([N+](=O)[O-])c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090156612A1,Cc1nc2cc(N(CC[C@@H]3CN(C(=O)OCc4ccccc4)CCN3C(=O)OC(C)(C)C)S(=O)(=O)c3ccccc3[N+](=O)[O-])ccc2s1>>Cc1nc2cc(N(CC[C@@H]3CN(C(=O)OCc4ccccc4)CCN3)S(=O)(=O)c3ccccc3[N+](=O)[O-])ccc2s1,,CCOC(C)=O,,Cl,,val
US20020045546A1,CC(C)N=C=NC(C)C.CCCCCCCCCCCCCCCCCC(=O)NN.CCCCCCCCCCCCCCCCCC(=O)O>>CCCCCCCCCCCCCCCCCCC(=O)NNC(=O)CCCCCCCCCCCCCCCCC,,C1CCOC1,,On1nnc2ccccc21,,val
US03937715,Nc1nnc(C(F)(F)C(Cl)Cl)s1.O=C(Cl)Cl>>O=C=Nc1nnc(C(F)(F)C(Cl)Cl)s1,,Clc1ccccc1,,,,val
US20160122341A1,Cc1cc(OCc2c(F)ccc(F)c2F)c2nc(C)c(C(=O)O)n2c1>>Cc1cc(OCc2c(F)ccc(F)c2F)c2nc(C)cn2c1,,C1COCCO1,,Cl,,val
US20060148888A1,O=C(O)CC1CCOc2cc(S(=O)(=O)c3cccc(F)c3)ccc21>>O=S(=O)(c1cccc(F)c1)c1ccc2c(c1)OCCC2CCO,,C1CCOC1,,CSC,,val
US20080319074A1,C=CCC(CO)(CC=C)c1ccc(C(=O)O)cc1.CI>>C=CCC(CO)(CC=C)c1ccc(C(=O)OC)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04198532,CC(=CC=O)CC(C)C.CC(C)Cl>>CC(=CC(O)C(C)C)CC(C)C,,CCOCC,,[Mg],,val
US20160045505A1,C1COCCN1.Cc1nc(C)c(C(=O)Nc2ccc(F)c(-c3cn4cc(C#CCCO)cnc4n3)c2)o1>>Cc1nc(C)c(C(=O)Nc2ccc(F)c(-c3cn4cc(C#CCCN5CCOCC5)cnc4n3)c2)o1,,c1ccncc1,,CS(=O)(=O)Cl,,val
US20120264737A1,COC(=O)c1cc(C(=N)N)c(C2CCC2)cc1C.COCC(=O)CBr>>COCc1cnc(-c2cc(C(=O)OC)c(C)cc2C2CCC2)[nH]1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20110312936A1,CC(C)(C)OC(=O)N1CC(NC(=O)CN)C1.FC(F)(F)c1ccc2cnnc(Cl)c2c1>>CC(C)(C)OC(=O)N1CC(NC(=O)CNc2c(C(F)(F)F)ccc3cnncc23)C1,,COCCOCCOC,,CCN(CC)CC,,val
US20050107310A1,COc1ccc(C=O)cc1.N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O>>COc1ccc(C=N[C@H]2C(O)O[C@H](CO)[C@@H](O)[C@@H]2O)cc1,,[Na+],[OH-],Cl,,val
US20100240641A1,COC(=O)C#N.COc1cc(C#N)ccc1Cn1cncc1C(C)(C)O[SiH2]C(C)(C)C>>COC(=O)C(c1ccc(C#N)cc1OC)n1cncc1C(C)(C)O[SiH2]C(C)(C)C,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US07189850B2,CC(C)CCN1CNC(=O)C12CCN(Cc1ccccc1)CC2>>CC(C)CCN1CNC(=O)C12CCNCC2,[Pd],CO,,[H][H],,val
US20020045619A1,COC(=O)c1ccc2nnc(C(=O)NCc3ccc(Cl)cc3)c(O)c2c1>>O=C(NCc1ccc(Cl)cc1)c1nnc2ccc(CO)cc2c1O,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120029026A1,CNc1cc(F)ccc1[N+](=O)[O-].Cc1cc(O)cc(O)n1>>CNc1cc(Oc2cc(C)nc(O)c2)ccc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05210276,CC(C)(C)OC(=O)NCC1CCc2ccc(O)cc2C1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)NCC1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1,,c1ccncc1,,,,val
US20120295842A1,CCOC(=O)[C@@]12C[C@H]1C=CCCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](OS(=O)(=O)c3ccc(Br)cc3)C[C@H]1C(=O)N2.Oc1nc2cc(F)ccc2c2ccccc12>>CCOC(=O)[C@@]12C[C@H]1C=CCCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Oc3nc4cc(F)ccc4c4ccccc34)C[C@H]1C(=O)N2,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090221555A1,CC(C)N1CC2CCC(C1)c1cc([N+](=O)[O-])ccc12>>CC(C)N1CC2CCC(C1)c1cc(N)ccc12,[Pd],CO,,,,val
US04266014,CCOC(=O)CC(=O)c1cccc([N+](=O)[O-])c1.NNCC(F)(F)F>>O=C1CC(c2cccc([N+](=O)[O-])c2)=NN1CC(F)(F)F,,CC(=O)O,O,,,val
US20070142638A1,COC(=O)CCc1ccccc1NC(=O)[C@H](CCCNC(=O)n1ccnc1)NC(=O)OC(C)(C)C.Cc1ccc(CO)cc1>>COC(=O)CCc1ccccc1NC(=O)[C@H](CCCNC(=O)OCc1ccc(C)cc1)NC(=O)OC(C)(C)C,,CC#N,,,,val
US20160229843A1,COC(=N)C(Cl)(Cl)Cl.Nc1ccc(F)cc1N>>Fc1ccc2[nH]c(C(Cl)(Cl)Cl)nc2c1,,CC(=O)O,,O,,val
US20080004302A1,CC#N.COC(=O)CCc1cccc(OC)n1.NN>>COc1cccc(CCc2cc(N)n[nH]2)n1,,C1CCOC1,CCO,Cl,CC(C)[N-]C(C)C.[Li+],val
US20090105249A1,CC(C)c1ccc(CBr)cc1.O=S(=O)(c1ccccc1)N(C1CCNCC1)C1CC1>>CC(C)c1ccc(CN2CCC(N(C3CC3)S(=O)(=O)c3ccccc3)CC2)cc1,,CN(C)C=O,,CCN(CC)CC,,val
US05134111,CC(=O)OC(C)=O.Cc1cccc2c(C=O)cc(C(C)C)c(O)c12>>CC(=O)Oc1c(C(C)C)cc(C=O)c2cccc(C)c12,,c1ccncc1,,O,,val
US06358948B1,CC(C)=O.CC(O)c1cc(-c2cccc([N+](=O)[O-])c2)ccc1N>>CC1OC(C)(C)Nc2ccc(-c3cccc([N+](=O)[O-])c3)cc21,,O,,,,val
US20130029961A1,CC(C)(C)[Si](C)(C)Cl.Nc1cncc(CO)c1>>CC(C)(C)[Si](C)(C)OCc1cncc(N)c1,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US20140154179A1,COC(=O)c1ncn(-c2ccc(I)cc2)n1>>O=C(O)c1ncn(-c2ccc(I)cc2)n1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20150065482A1,CO.COC(=O)c1nn(-c2cccc(Br)c2)c2cc(Cl)ncc12>>COc1cc2c(cn1)c(C(=O)O)nn2-c1cccc(Br)c1,,CN(C)C=O,,Cl,C[O-].[Na+],val
US20160039808A1,C[C@H](c1ccccc1)n1cc(O)cn1.Oc1nc(Cl)nc2cnccc12>>C[C@H](c1ccccc1)n1cc(Oc2nc(O)c3ccncc3n2)cn1,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05342846,COc1c(F)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12.Cc1cnnn1C1CCNC1>>COc1c(N2CCC(n3nncc3C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,,CC#N,,C1CCC2=NCCCN2CC1,Cl,val
US20100160302A1,O=C(NC12CC3CC1CC(c1ccc(-n4cccc4)cc1)(C3)C2)OCc1ccccc1>>NC12CC3CC1CC(c1ccc(-n4cccc4)cc1)(C3)C2,,CO,,,,val
US20050239797A1,CN1CCN(c2nccc3ccc(N)cc23)CC1.O=C(Cl)c1ccc(Cl)cc1>>CN1CCN(c2nccc3ccc(NC(=O)c4ccc(Cl)cc4)cc23)CC1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20120238599A1,CCOC(=O)CC(=O)C(C)C(=O)OCC.CN=C=Nc1ccc(I)cc1F>>CCOC(=O)c1c(O)c(C)c(=O)n(C)c1Nc1ccc(I)cc1F,,C1CCOC1,,[H-].[Na+],,val
US20060111431A1,ClCCOc1ccccc1Br.NCCc1ccccc1Cl>>Clc1ccccc1CCNCCOc1ccccc1Br,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160067345A1,CC[C@]1(S[C@H]2O[C@H](C)[C@@H](N=[N+]=[N-])[C@H](OCc3ccccc3)[C@@H]2O)O[C@H](C)[C@@H](N=[N+]=[N-])[C@H](OCc2ccccc2)[C@@H]1OC(C)=O>>CC[C@]1(S[C@H]2O[C@H](C)[C@@H](N=[N+]=[N-])[C@H](OCc3ccccc3)[C@@H]2O)O[C@H](C)[C@@H](N=[N+]=[N-])[C@H](OCc2ccccc2)[C@@H]1O,,CO,,C[O-].[Na+],,val
US05658491,CCCCCCOc1cnc(-c2ccc(O)cc2)nc1.FC(F)(COCCCCCCCBr)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>CCCCCCOc1cnc(-c2ccc(OCCCCCCCOCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc2)nc1,,O,,,,val
US20120095031A1,COCn1c(C)nc(C)c(I)c1=O.OCc1ccccc1>>COCn1c(C)nc(C)c(OCc2ccccc2)c1=O,I[Cu]I,CCOC(C)=O,Cc1ccccc1,c1cnc2c(c1)ccc1cccnc12,O=C([O-])[O-].[Cs+].[Cs+],val
US20080176926A1,CCOC(=O)C=Cc1c(C)cc(C=CC(=O)c2sc(C(F)(F)F)c3c2CCC(C)(C)C3)cc1CC>>CCOC(=O)CCc1c(C)cc(CCC(=O)c2sc(C(F)(F)F)c3c2CCC(C)(C)C3)cc1CC,[Pd],CCO,,,,val
US20150171351A1,CC(C)(C)c1ccnc(Cl)c1.OB(O)c1ccc(F)nc1F>>CC(C)(C)c1ccnc(-c2ccc(F)nc2F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20040014753A1,C=CCOC(=O)NC1CC(=O)OC1OCC.O=C(N[C@H]1CC=CC[C@@H]2CCC[C@@H](C(=O)O)N2C1=O)c1ccccc1>>CCOC1OC(=O)CC1NC(=O)[C@@H]1CCC[C@@H]2CC=CC[C@H](NC(=O)c3ccccc3)C(=O)N21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,ClCCl,On1nnc2ccccc21,,val
US20110152238A1,COc1cccc(C(c2ccc(C(=O)N(C)C)cc2)N2CCC3CCC(C2)N3C)c1>>COc1cccc(C(c2ccc(C(=O)N(C)C)cc2)N2CCC3CCC(C2)N3)c1,[Zn],CC(=O)O,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US20100022525A1,CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.On1nnc2ccccc21>>CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.On1nnc2ccccc21,,CN(C)C=O,,O,,val
US20060111402A1,Clc1ccccc1CBr.FC(F)(F)Cc1cc2cc(Cl)c(Cl)cc2[nH]1.FC(F)(F)Cc1nc2c(Cl)cccc2n1Cl>>FC(F)(F)Cc1nc2cc(Cl)c(Cl)cc2n1Cc1ccccc1Cl,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20110046147A1,COc1ccc(C(=O)CBr)cc1.c1ccc2[nH]nnc2c1>>COc1ccc(C(=O)Cn2nnc3ccccc32)cc1,,C1CCOC1,,[H-].[Na+],,val
US04009210,C=O.CC(C)(C)c1cccc(C(C)(C)C)c1O>>CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O,,CC(=O)O,O,C,O=C[O-].[NH4+],val
US20110212918A1,CC(=O)Nc1cnc(S(=O)(=O)Cl)c(Br)c1.Nc1ccc2c(c1)B(O)OC2>>CC(=O)Nc1cnc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(Br)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150336938A1,CI.COc1cc2c(O)c3c(c(/C=C/c4ccccc4)c2cc1OC)C(=O)OC3>>COc1cc2c(/C=C/c3ccccc3)c3c(c(OC)c2cc1OC)COC3=O,,CN(C)C=O,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US04912226,COc1ccc(NC(=S)NCC(OC)OC)cc1>>COc1ccc(-n2ccnc2S)cc1,,O,,O=S(=O)(O)O,,val
US04619941,NCCCCCn1ccnc1.O=C(O)c1cc2cc(Cl)ccc2[nH]1>>O=C(NCCCCCn1ccnc1)c1cc2cc(Cl)ccc2[nH]1,,C1CCOC1,,O,O=C(n1ccnc1)n1ccnc1,val
US07612075B2,CC(C)(C)OC(=O)Nc1ccncc1C#CCN1CCN(Cc2cc3cnccc3n2C(=O)OC(C)(C)C)C(=O)C1>>CC(C)(C)OC(=O)n1c(CN2CCN(Cc3cc4cnccc4n3C(=O)OC(C)(C)C)C(=O)C2)cc2cnccc21,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20030105333A1,Cc1ccc(/C=C/C(O)C(C)C)cc1>>Cc1ccc(CCC(O)C(C)C)cc1,[Pd],CCOC(C)=O,CO,,,val
US20130116235A1,Cn1cc(B2OC(C)(C)C(C)(C)O2)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O.O=Cc1c(N2CCn3c(cc4c3CCCC4)C2=O)ccnc1Cl>>Cn1cc(-c2nccc(N3CCn4c(cc5c4CCCC5)C3=O)c2C=O)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O,[Pd],C1CCOC1,,,,val
US20050137240A1,COc1ccccc1OCCCC(=O)O>>COc1cccc2c1OCCCC2=O,,Cc1ccccc1,,,,val
US20100305065A1,Cc1cc(N2CCC(NC(=O)OC(C)(C)C)C2)c2cc(Oc3ccccc3)ccc2n1>>Cc1cc(N2CCC(N)C2)c2cc(Oc3ccccc3)ccc2n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05643908,CC(C)(C)OC(=O)CBr.CCCCCCC(=O)N1C(=O)OC[C@@H]1C(C)C>>CCCCC[C@H](CC(=O)OC(C)(C)C)C(=O)N1C(=O)OC[C@@H]1C(C)C,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20160272595A1,Cc1ccc([N+](=O)[O-])c(C(=O)O)c1.O=C1CCC(=O)N1Br>>Cc1cc(C(=O)O)c([N+](=O)[O-])cc1Br,,O,,O=S(=O)(O)O,,val
US20120208821A1,Cc1c([N+](=O)[O-])cnc2c1ccn2S(=O)(=O)c1ccccc1>>Cc1c(N)cnc2c1ccn2S(=O)(=O)c1ccccc1,[Pd],C1CCOC1,CCO,[H][H],,val
US20150210687A1,C1=COCCC1.Fc1cccc2[nH]nc(I)c12>>Fc1cccc2c1c(I)nn2C1CCCCO1,,C1CCOC1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04939137,COC(=O)c1cscc1N.O=C=NCCCCBr>>COC(=O)c1cscc1NC(=O)NCCCCBr,,Cc1ccccc1,,,,val
US20070043040A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=S(=O)(NCCNCCOc1ccc(Cl)cc1Br)c1cccc2c(O)nccc12>>CC(C)(C)OC(=O)N(CCNS(=O)(=O)c1cccc2c(O)nccc12)CCOc1ccc(Cl)cc1Br,,ClCCl,,CO,,val
US06011031,O=Cc1ccc(OCCBr)cc1.c1ccc2c(c1)Nc1ccccc1O2>>O=Cc1ccc(OCCN2c3ccccc3Oc3ccccc32)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20080280933A1,CCOC(OCC)c1nc2cc(C#N)ccc2n1C.Cl>>Cl.Cn1c(C=O)nc2cc(C#N)ccc21.O,,C1COCCO1,,,,val
US20140100154A1,CC(C)C[C@H](NC(=O)[C@@H](N)CCc1ccccc1)C(=O)OCc1ccccc1.CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1>>NNC(=O)CCCC(=O)O,,CO,,Cl,O=C(O)C(F)(F)F,val
US04997836,CC(=O)OC(C)=O.COc1cc2c(cc1OC)CCCC(C(=O)N1CCN(Cc3cc(OC)c(OC)c(OC)c3)CC1CO)=C2>>COc1cc2c(cc1OC)CCCC(C(=O)N1CCN(Cc3cc(OC)c(OC)c(OC)c3)CC1COC(C)=O)=C2,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20110230458A1,CC(C)(C)OC(=O)N1CCC(F)(F)C(N=[N+]=[N-])C1>>CC(C)(C)OC(=O)N1CCC(F)(F)C(N)C1,[Pd],CO,,,,val
US20150104384A1,CC(=O)O.Cc1ncc(Br)cc1N>>CC(=O)Nc1cc(Br)cnc1C,,CC(=O)O,,CC(=O)OC(C)=O,,val
US20030055085A1,N#Cc1cc(F)cc(-c2nc(-c3ccccn3)no2)c1.c1c[nH]cn1>>N#Cc1cc(-c2nc(-c3ccccn3)no2)cc(-n2ccnc2)c1,,ClC(Cl)Cl,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150329538A1,C1CCNC1.Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1F>>Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N1CCCC1,,CS(C)=O,,CO,ClCCl,val
US07495007B2,O=C1Cc2ccc(Cl)cc2N1.O=Cc1cc(Cl)ccc1Cl>>O=C1Nc2cc(Cl)ccc2/C1=C/c1cc(Cl)ccc1Cl,,CO,,C1CCNC1,,val
US20110301170A1,COc1cccc(N)c1N.O=N[O-]>>COc1cccc2[nH]nnc12,,O,,CC(=O)O,,val
US20150216171A1,COC(=O)c1ccc2ccsc2c1C>>Cc1c(C(=O)O)ccc2ccsc12,,CO,O,[Na+].[OH-],,val
US20120214837A1,CCNc1nc2ccc(OCC)cc2cc1CCl.CCc1nc(O)cc2cc(OC)c(OC)cc12.Cl.ClCCl>>CCNc1nc2ccc(OCC)cc2cc1Cc1c(O)nc(CC)c2cc(OC)c(OC)cc12.Cl.Cl,,C1CCOC1,ClCCl,[Li+].[OH-],,val
US04457943,NC(=O)c1c(F)cccc1F.[C]=O>>O=C=NC(=O)c1c(F)cccc1F,,Cc1ccccc1,,Cl,O=C(Cl)C(=O)Cl,val
US20130109682A1,COC[C@H]1OC(c2ccncc2[N+](=O)[O-])=C[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]1O[Si](C(C)C)(C(C)C)C(C)C>>COC[C@H]1O[C@H](c2ccncc2N)C[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]1O[Si](C(C)C)(C(C)C)C(C)C,[Pd],CCO,,,,val
US20130029962A1,CCOC(=O)C(C(=O)OCC)c1ccc([N+](=O)[O-])cn1>>CCOC(=O)Cc1ccc([N+](=O)[O-])cn1,,CS(C)=O,,O,[Cl-].[Na+],val
US20130079341A1,Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1N.Cl>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1N.Cl,,C1COCCO1,,,,val
US05389614,CC(=O)N(CCC(=O)OC(C)(C)C)N1C(=O)N[C@@H](CCCNC(=N)N)C1=O>>CC(=O)N(CCC(=O)O)N1C(=O)N[C@@H](CCCNC(=N)N)C1=O,,O=C(O)C(F)(F)F,,,,val
US20040116698A1,Cn1c(=O)c(Oc2ccccc2F)cc2cnc(S(C)(=O)=O)nc21.NCCN1CCCCC1>>Cn1c(=O)c(Oc2ccccc2F)cc2cnc(NCCN3CCCCC3)nc21,,ClC(Cl)Cl,,,,val
US20120071466A1,COC(=O)CCN.O=C(Cl)N1CCCC2CCCCC21>>COC(=O)CCNC(=O)N1CCCC2CCCCC21,,C1CCOC1,CCN(CC)CC,CCOC(C)=O,Cl,val
US20150191461A1,O=P(Cl)(Cl)Cl.Oc1nccc(C(F)F)n1>>FC(F)c1ccnc(Cl)n1,,ClCCl,,O,,val
US20140148440A1,BrBr.O=C1CCCN(C(=O)C2CC2)CC1>>O=C1CCN(C(=O)C2CC2)CCC1Br,,CC(=O)O,,,,val
US04725531,Cc1cc(S(=O)(=O)O)c(C)cc1N=Nc1c(C#N)[nH]n(-c2ccccc2C)c1=O.O=P(Cl)(Cl)Cl>>Cc1cc(S(=O)(=O)Cl)c(C)cc1N=Nc1c(C#N)[nH]n(-c2ccccc2C)c1=O,,CC(=O)N(C)C,,CC#N,,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccsc4)nc(Cl)c3n2)cc1.Nc1ccc2c(c1)NC(=O)CS2>>O=C1CSc2ccc(Nc3nc(-c4ccsc4)nc4cn[nH]c34)cc2N1,C1COCCO1,CO,,Cl,,val
US20030199440A1,N=C(N)Nc1ncc(Cl)c2ccc(C(=O)NC(CC(=O)[O-])c3ccccc3)cc12.O=C(O)C(F)(F)F>>N=C(N)Nc1ncc(Cl)c2ccc(C(=O)NC(CC(=O)O)c3ccccc3)cc12.O=C(O)C(F)(F)F,,Cc1ccccc1,,,,val
US20130005771A1,CCCCCc1noc(C=Cc2ccc(OC)c(OC)c2)n1>>CCCCCc1noc(C=Cc2ccc(O)c(O)c2)n1,,ClCCl,,BrB(Br)Br,,val
US20080153802A1,CCC(C)N.O=C(O)c1cccc(-c2ccccc2)c1>>CCC(C)NC(=O)c1cccc(-c2ccccc2)c1,,C1CCOC1,CN(C)C=O,O=C(Cl)C(=O)Cl,,val
US20090186884A1,C[Si](C)(C)CCOC(=O)NC[C@H](O)[C@@H](N)CC1CCCCC1.C[Si](C)(C)Cl>>C[Si](C)(C)CCOC(=O)NC[C@H](O[Si](C)(C)C)[C@@H](N)CC1CCCCC1,,ClCCl,,CCN(CC)CC,,val
US20070043061A1,N#CCCNc1nonc1-c1nc2ccccc2[nH]1.O=C(CBr)c1ccc(Cl)cc1>>N#CCCNc1nonc1-c1nc2ccccc2n1CC(=O)c1ccc(Cl)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US05252747,C[C@H]1C[C@H](NC(=O)OC(C)(C)C)CN1Cc1ccccc1>>C[C@H]1C[C@H](NC(=O)OC(C)(C)C)CN1,[Pd],CO,,[H][H],,val
US20110046131A1,CC(=O)N(C)C.NCc1cccs1.Nc1cncnc1.O=Cc1c(Cl)cccc1Cl.c1ncc2[nH]cnc2n1>>Clc1cccc(Cl)c1-c1nc2cnc(NCc3cccs3)nc2n1C[C@@H]1CCCNC1,,CC(=O)O,,,,val
US20130324516A1,Nc1cc(F)cc(-c2ccc3ncnc(N)c3c2)c1.O=C(O)CN1CCOCC1>>Nc1ncnc2ccc(-c3cc(F)cc(NC(=O)CN4CCOCC4)c3)cc12,,ClCCl,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US05864039,COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCN)CC1,,CCO,,NN,O,val
US20140140956A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cc(C(=O)N(C)C)ccc1Br>>Cc1cc(C(=O)N(C)C)ccc1B1OC(C)(C)C(C)(C)O1,,CS(C)=O,,CC(=O)[O-].[K+],,val
US20080153810A1,CN1CCN(c2n[nH]c3ccc([N+](=O)[O-])cc23)CC1>>CN1CCN(c2n[nH]c3ccc(N)cc23)CC1,[Pd],CO,,,,val
US20070142432A1,COC(=O)CCBr.c1ccc(Oc2ccc(OC3CCNCC3)cc2)cc1>>COC(=O)CCN1CCC(Oc2ccc(Oc3ccccc3)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US05179206,CC1CCCC(C)N1N.CC=O.[C-]#N>>CC(C#N)NN1C(C)CCCC1C,,CO,O,Cl,,val
US20150284411A1,C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@@H]3C(CC(N)=O)CO[C@H]23)nc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc21>>OCCC1CO[C@@H]2[C@H](Oc3nc4nc(-c5ccc(-c6ccccc6)cc5)c(Cl)cc4[nH]3)CO[C@H]12,,O=C(O)C(F)(F)F,,ClCCl,,val
US20080170993A1,COC(=O)c1ccc(N(C)C)cc1Cl.COS(=O)(=O)C(F)(F)F>>COC(=O)c1ccc([N+](C)(C)C)cc1Cl.O=S(=O)([O-])C(F)(F)F,,CCOCC,,ClCCl,,val
US05432182,CCCC(=O)c1cnc2c(O)cccc2c1Nc1ccc(F)cc1C.OCCCl>>CCCC(=O)c1cnc2c(OCCO)cccc2c1Nc1ccc(F)cc1C,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20160272596A1,CC(C)(C)OC(=O)N[C@H]1CNc2ccccc2NC1=O.O=C(Cl)c1ccc(F)cc1>>CC(C)(C)OC(=O)N[C@H]1CN(C(=O)c2ccc(F)cc2)c2ccccc2NC1=O,,ClCCl,O,c1ccncc1,,val
US20060252812A1,CCCCCN1C(=O)C2(CC(O)c3cc4c(cc32)OCO4)c2ccccc21.CI>>CCCCCN1CC2(CC(OC)c3cc4c(cc32)OCO4)c2ccccc21,,C1CCOC1,,O,[H-].[Na+],val
US20130012499A1,CO.Cc1c(-c2cccc(C(F)(F)F)c2)nc2cc(O)c(S(C)(=O)=O)cc2c1C(=O)O>>COC(=O)c1c(C)c(-c2cccc(C(F)(F)F)c2)nc2cc(O)c(S(C)(=O)=O)cc12,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20140066426A1,BrCc1ccccc1.CCOC(=O)c1[nH]cc(C)c1-c1ccc(Cl)cc1F>>CCOC(=O)c1c(-c2ccc(Cl)cc2F)c(C)cn1Cc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20140005213A1,COc1ccc(C(O[C@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2OS(C)(=O)=O)(c2ccccc2)c2ccc(OC)cc2)cc1.[N-]=[N+]=[N-]>>COc1ccc(C(O[C@H]2CN(C(=O)OC(C)(C)C)C[C@H]2N=[N+]=[N-])(c2ccccc2)c2ccc(OC)cc2)cc1,,CS(C)=O,,O,,val
US20150087585A1,CC(C)(C)OC(=O)N1CCC[C@@H](C(=O)O)C1.Nc1ccc(N2CCC[C@@H](C(=O)N3CCCC3)C2)nc1N>>CC(C)(C)OC(=O)N1CCCC(C(=O)Nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2N)C1,,C1COCCO1,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US20040198711A1,COCO[C@H]1C[C@H](C)[C@H]2[C@@H]3CCc4cc(OC)ccc4[C@H]3CC[C@@]21C>>COc1ccc2c(c1)CC[C@H]1[C@@H]3[C@@H](C)C[C@H](O)[C@@]3(C)CC[C@H]21,,CO,,Cl,O=C([O-])O.[Na+],val
US20130210796A1,C=O.CC(C)N.C[Si](C)(C)N=[N+]=[N-].[C-]#[N+]c1ccc(C(F)(F)F)cc1>>CC(C)NCc1nnnn1-c1ccc(C(F)(F)F)cc1,,CO,,,,val
US20110204341A1,CCCCC(C#Cc1c2ccsc2c(C#CC(CC)CCCC)c2ccsc12)CC>>CCCCC(CC)CCc1c2ccsc2c(CCC(CC)CCCC)c2ccsc12,[Pd],C1CCOC1,,,,val
US20020045623A1,CC(C)(C)OC(=O)[C@@H]1CCCCN1C(=O)OC(C)(C)C.O>>CC(C)(C)OC(=O)[C@@H]1CCCC(=O)N1C(=O)OC(C)(C)C,,CCOC(C)=O,,,,val
US20060276536A1,CN.O=C(C=Cc1ccc2ccccc2c1)C=Cc1ccc2ccccc2c1>>CN1C(c2ccc3ccccc3c2)CC(=O)CC1c1ccc2ccccc2c1,,CN(C)C=O,,O,,val
US20020090728A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.Fc1nc(F)nc(F)n1>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)F,,ClCCl,,c1ccncc1,,val
US20130045980A1,Cc1ccncc1B(O)O.Clc1cc(Br)c2nccn2n1>>Cc1ccncc1-c1cc(Cl)nn2ccnc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20080221110A1,CCOC(=O)c1c[nH]c(=O)c(I)c1.OCCS>>CCOC(=O)c1c[nH]c(=O)c(SCCO)c1,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070072897A1,CCOC(=O)/C=C/c1cc(F)cc(Cl)c1>>OC/C=C/c1cc(F)cc(Cl)c1,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US20130116235A1,CN1CCn2nc(Nc3cc(-c4ccnc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4C=O)cn(C)c3=O)cc2C1>>CN1CCn2nc(Nc3cc(-c4ccnc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)cc2C1,,CO,,[BH4-].[Na+],,val
US20060287341A1,CSc1nc(Cl)c(-c2ccccc2)c(-c2ccc(Cl)cc2)n1.NN>>CSc1nc(NN)c(-c2ccccc2)c(-c2ccc(Cl)cc2)n1,,C1CCOC1,,,,val
US04436753,COC1=C(OC)C(=O)C(CCCCCCCCCCCCOC(C)=O)=C(C)C1=O>>COC1=C(OC)C(=O)C(CCCCCCCCCCCCO)=C(C)C1=O,,CO,,Cl,O=C([O-])O.[Na+],val
US04855455,CC(C)NC(=O)C(C)N=[N+]=[N-]>>CC(C)NC(=O)[C@@H](C)N,[Ni],CC(C)O,,,,val
US20110275636A1,COC(=O)c1ccn(-c2ccc(OC)cc2OC)n1>>COC(=O)c1ccn(-c2ccc(O)cc2O)n1,,ClCCl,,BrB(Br)Br,,val
US20140038999A1,C=Cc1cc2c3ccncc3c(=O)n(C)c2cc1OC[C@H](CC(C)C)NC(=O)OC(C)(C)C>>CCc1cc2c3ccncc3c(=O)n(C)c2cc1OC[C@H](CC(C)C)NC(=O)OC(C)(C)C,[Pd],CCOC(C)=O,CO,[H][H],,val
US20160002241A1,C=CC(=O)Nc1cccc(N)c1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>C=CC(=O)Nc1cccc(Nc2nc(Cl)ncc2[N+](=O)[O-])c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US06080781,CCOc1cc(C=O)ccc1OC.O=c1ccoc2cc(O)ccc12>>CCOc1cc(C=C2COc3cc(O)ccc3C2=O)ccc1OC,,O,,CO,Cl,val
US20130109718A1,CNOC.Cc1ccccc1C(CC(=O)O)c1ccc(Br)cc1>>CON(C)C(=O)CC(c1ccc(Br)cc1)c1ccccc1C,,ClCCl,,Cl,O=C(n1ccnc1)n1ccnc1,val
US20110015240A1,CC(=O)Nc1nc(CCc2ccc(O)cc2)cs1.CC(C)(C)OC(=O)NN.O=C(n1ccnc1)n1ccnc1>>CC(=O)Nc1nc(CCc2ccc(OC(=O)NNC(=O)OC(C)(C)C)cc2)cs1,,C1CCOC1,,,,val
US20080090836A1,CCCCc1c[nH]nc1C(=O)O.Nc1ccc(F)cc1Cl>>CCCCc1c[nH]nc1C(=O)Nc1ccc(F)cc1Cl,CN(C)c1ccncc1,Cc1ccccc1,ClCCl,O=S(Cl)Cl,c1ccncc1,val
US20100311966A1,CCCCOC(=O)C(=O)C(Br)CC.CO[C@@H]1CN(C(N)=O)CC[C@@H]1NC(=O)OCc1ccccc1>>CCOC(=O)c1nc(N2CC[C@H](NC(=O)OCc3ccccc3)[C@H](OC)C2)oc1CC,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20060173034A1,Cc1c(N)cccc1CO.NC(=O)C1(Cl)C=c2cc3c(cc2=NC1)OCO3>>Cc1c(CO)cccc1Nc1c(C(N)=O)cnc2ccccc12,,CN(C)C=O,O,CC(=O)O,,val
US20130150325A1,COC(=O)C(C)(C)Sc1ccc(/C=C(\F)c2cc(C)[nH]n2)cc1.ClCc1ccc(Cl)nc1>>Cc1cc(/C(F)=C/c2ccc(SC(C)(C)C(=O)O)cc2)nn1Cc1ccc(Cl)nc1,,C1CCOC1,,CCOC(C)=O,CC(C)(C)[O-].[K+],val
US06313132B1,CC(C)N(CCC(C(N)=O)c1ccccc1)C(C)C.CCOC(Cl)CCl>>CC(C)N(CCC(c1ccccc1)c1ncco1)C(C)C.Cl,,O=CO,,O,,val
US20090062258A1,CC(C)(C)OC(=O)CNC(=O)c1scc2[nH]c(=O)n(-c3cccc(S(=O)(=O)N4CCCc5ccccc54)c3)c(=O)c12>>O=C(O)CNC(=O)c1scc2[nH]c(=O)n(-c3cccc(S(=O)(=O)N4CCCc5ccccc54)c3)c(=O)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110190278A1,COC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1c1ccccc1>>COC(=O)[C@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1c1ccccc1,,CO,,C[O-].[Na+],,val
US20050267149A1,CCN(CCc1ccccn1)C(=O)CCc1ccc(OCc2ccccc2C(=O)OC)cc1>>CCN(CCc1ccccn1)C(=O)CCc1ccc(OCc2ccccc2C(=O)O)cc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20100035936A1,Cc1nn(C)c(C)c1-c1cccc2c1CC[C@H](N(Cc1ccccc1)C(=O)C(C)(C)C)C2>>Cc1nn(C)c(C)c1-c1cccc2c1CC[C@H](NCc1ccccc1)C2,,ClCCl,,O,O=C(O)C(F)(F)F,val
US04544670,Cc1onc(-c2ccccc2)c1C(=O)C(=O)O.O=S(Cl)Cl>>Cc1onc(-c2ccccc2)c1C(=O)Cl,c1ccncc1,,,,,val
US20120238587A1,CC1(C)OB(c2cnc(Cl)c(NS(=O)(=O)c3ccccc3)c2)OC1(C)C.Clc1ccc2ncnc(OC3CCOCC3)c2n1>>O=S(=O)(Nc1cc(-c2ccc3ncnc(OC4CCOCC4)c3n2)cnc1Cl)c1ccccc1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US05081145,CCCC(=O)C(C)CC(=O)O.NN(Cc1ccc(Cl)cc1)c1ccc(F)cc1>>Cc1c(CC(C)CC(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(F)cc12,,CC(C)O,,Cl,,val
US20050182040A1,N#Cc1ccc(N2CCN(Cc3ccccc3)CC2)cc1.O=S(=O)(O)O>>NC(=O)c1ccc(N2CCN(Cc3ccccc3)CC2)cc1,,O=S(=O)(O)O,,[Na+].[OH-],,val
US04247705,CCN1CC(CCN(Cc2ccccc2)Cc2ccccc2)N(c2ccccc2)C1=N.Cl.Cl>>CCN1CC(CCN)N(c2ccccc2)C1=N.Cl.Cl,[Pd],CCO,,O,[H][H],val
US20160218303A1,CI.N#Cc1ccc2ncn(-c3ccccc3)c2c1>>C[n+]1cn(-c2ccccc2)c2cc(C#N)ccc21.[I-],,Cc1ccccc1,,,,val
US20070299085A1,FC(F)(F)C(F)(F)I.FC(F)(F)C(F)(F)c1n[nH]cc1I>>FC(F)(F)C(F)(F)c1c[nH]nc1C(F)(F)C(F)(F)F,[Cu],CN(C)C=O,,,,val
US20140235620A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@H](N)c1cccc(O)c1>>C[C@H](NC(=O)OC(C)(C)C)c1cccc(O)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04755323,CCCCCC(CO)OCC(O)c1ccc(OCC)cc1>>CCCCC[C@@H]1CO[C@@H](c2ccc(OCC)cc2)CO1,,O,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US04333937,COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC.COc1cccccc1=O>>COc1cc2nc(N3CCN(c4cccccc4=O)CC3)nc(N)c2cc1OC,,CCCCO,,CCN(CC)CC,,val
US20030073847A1,OCc1ccncc1.Oc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl>>ClC(Cl)=CCOc1cc(Cl)c(OCc2ccncc2)c(Cl)c1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04337250,ClCCCCCl.O=C1CCCCN1>>O=C1CCCCN1CCCCCl,,CN(C)C=O,,[H-].[Na+],,val
US20150065705A1,Clc1ccc(CBr)cc1.O=c1nc(N2CCN(c3ccc(F)cc3)CC2)nc[nH]1>>O=c1nc(N2CCN(c3ccc(F)cc3)CC2)ncn1Cc1ccc(Cl)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20040102324A1,CNC(=O)c1cc(C)nc(NC(=O)c2cc(Cl)nn2-c2ncccc2Cl)n1.Cc1ncnc(C(=O)[O-])c1N>>Cc1ncnc2c(=O)oc(-c3cc(Cl)nn3-c3ncccc3Cl)nc12,,CC#N,O,CCN(CC)CC,CS(=O)(=O)Cl,val
US20110224155A1,Cc1cc(N)c(C#N)s1.NS(=O)(=O)Cl>>Cc1cc2c(s1)C(N)=NS(=O)(=O)N2,,CC(=O)N(C)C,O,Cl,[Na+].[OH-],val
US20140336190A1,Cc1noc(C)c1-c1cc(C(O)c2ccccn2)c2nc(C3CC3)[nH]c2c1.O=C1CCCC1>>Cc1noc(C)c1-c1cc(C(O)(c2ccccn2)C2CCCC2=O)c2nc(C3CC3)[nH]c2c1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20090209607A1,CCCc1sc(C(=O)O)cc1-c1c(C)cnn1C.N[C@@H](Cc1ccccc1C(F)(F)F)CN1C(=O)c2ccccc2C1=O>>CCCc1sc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)cc1-c1c(C)cnn1C,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20110245272A1,CC(=CBr)c1ccc(C)nc1.Cc1ccc2[nH]c3c(c2c1)C1CCCN1CC3>>C/C(=C\n1c2c(c3cc(C)ccc31)C1CCCN1CC2)c1ccc(C)nc1,I[Cu]I,CN(C)C=O,O,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20140112945A1,COc1ccc(C2=NN(C3CCN(C(=O)CNC(=O)OC(C)(C)C)CC3)C(=O)C3(CCCC3)C2)cc1OC>>COc1ccc(C2=NN(C3CCN(C(=O)CN)CC3)C(=O)C3(CCCC3)C2)cc1OC,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20120010247A1,BrC(Br)(Br)Br.Cc1nc2ccc(CO)cc2o1>>Cc1nc2ccc(CBr)cc2o1,,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050148624A1,C[Mg]Br.O=Cc1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccccc1>>CC(O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccccc1,,C1CCOC1,,O,,val
US20090012126A1,O=C1CC[C@H](CO)N1.[N-]=[N+]=N>>[N-]=[N+]=NC[C@H]1CCC(=O)N1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050124555A1,COC(=O)c1ccc(C)c([C@@H]2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)c1>>Cc1ccc(CO)cc1[C@@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20160130253A1,CCOC(=O)CBr.O=C(Cc1ccncc1)c1ccccc1>>CCOC(=O)CC(C(=O)c1ccccc1)c1ccncc1,,C1CCOC1,,[H-].[Na+],,val
US20040162303A1,COc1c(O[Si](C)(C)C(C)(C)C)cc(F)c(F)c1C(=O)c1cnc(Cl)nc1Cl.N>>COc1c(O[Si](C)(C)C(C)(C)C)cc(F)c(F)c1C(=O)c1cnc(Cl)nc1N,,Cc1ccccc1,,,,val
US20060235013A1,CCN1C(=O)C(C)(C)c2cc3nc(-c4n[nH]c5c4CNCC5)[nH]c3cc21.O=S(=O)(Cl)c1ccc(F)cc1>>CCN1C(=O)C(C)(C)c2cc3nc(-c4n[nH]c5c4CN(S(=O)(=O)c4ccc(F)cc4)CC5)[nH]c3cc21,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20100292210A1,COc1cc([N+](=O)[O-])ccc1F.Cc1c[nH]cn1>>COc1cc([N+](=O)[O-])ccc1-n1cnc(C)c1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20030207865A1,CC(C)CN[C@H](CO)CC(C)C.O=S(Cl)Cl>>CC(C)CN[C@H](CCl)CC(C)C.Cl,,Cc1ccccc1,,,,val
US20130274260A1,O=C(NCc1c[nH]c2ccc(Cl)cc12)c1ccc(CCl)cc1.OB(O)c1cc(F)cc(F)c1>>O=C(NCc1c[nH]c2ccc(Cl)cc12)c1ccc(Cc2cc(F)cc(F)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,[I-].[Na+],,val
US20130281359A1,CC(C)(C)OC(=O)n1cnc(CON)c1.O=C(O)[C@@H]1CC[C@@H]2CN1C(=O)N2OCc1ccccc1>>CC(C)(C)OC(=O)n1cnc(CONC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)c1,,ClCCl,,On1nnc2ccccc21,,val
US20100292236A1,NCC12CC3CC(CC(C3)C1)C2.O=C(O)c1cn(-c2ncccn2)nc1Cl>>O=C(NCC12CC3CC(CC(C3)C1)C2)c1cn(-c2ncccn2)nc1Cl,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US03980795,CC(O)(CC(=O)NN)c1ccc(-c2ccc(F)cc2)cc1>>CC1(c2ccc(-c3ccc(F)cc3)cc2)CC(=O)NN1,,CN(C)C=O,,,,val
US20080004271A1,CC[C@H](N)CO.CS(=O)c1nc(-c2cccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c2)c2c(N)c(C(N)=O)sc2n1>>CC[C@@H](CO)Nc1nc(-c2cccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c2)c2c(N)c(C(N)=O)sc2n1,,CCOC(C)=O,CN(C)C=O,,,val
US20120108589A1,Cc1cc(C#N)ccc1-n1nc(C(F)(F)F)c2c(=O)cc[nH]c21.O=S(Cl)Cl>>Cc1cc(C#N)ccc1-n1nc(C(F)(F)F)c2c(Cl)ccnc21,,ClC(Cl)Cl,,CN(C)C=O,O,val
US20040214035A1,Brc1cc2ccccc2c2ccccc12.CC(C)OB(OC(C)C)OC(C)C>>OB(O)c1cc2ccccc2c2ccccc12,,CCCCCC,CCOCC,Cl,[Li]CCCC,val
US20090048239A1,COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(CCC(=O)N1CCN(C(=O)OC(C)(C)C)CC1)COc1ccccc1-3>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(CCC(=O)N1CCNCC1)COc1ccccc1-3,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040242593A1,CCCCC1(c2cc(O)cc(O)c2)SCCS1.COc1cc(OC)cc(C(C)(C)C2CCCC2)c1>>CC(C)(c1cc(O)cc(O)c1)C1CCCC1,,CCCCCC,CCOCC,,,val
US20070037809A1,CC(C)(C)OC(=O)N1CCNCC1.O=[N+]([O-])c1ccccc1-c1nc2ccccn2c1CCl>>CC(C)(C)OC(=O)N1CCN(Cc2c(-c3ccccc3N)nc3ccccn23)CC1,,ClCCl,,CCN(CC)CC,,val
US20080287479A1,COC(=O)c1ccc([N+](=O)[O-])c(C(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1>>COC(=O)c1ccc(N)c(C(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1,[Ni],CO,,,,val
US20110077248A1,O=C1c2ccccc2C(=O)N1O.O=[N+]([O-])c1ccc(Cl)c([N+](=O)[O-])c1>>O=C1c2ccccc2C(=O)N1Oc1ccc([N+](=O)[O-])cc1[N+](=O)[O-],,CC(C)=O,,CCN(CC)CC,,val
US20130053364A1,CC(C)(C)O.O=C(O)c1c(CS(=O)(=O)c2ccccc2)ccc(-c2ccoc2)c1O>>CC(C)(C)OC(=O)c1c(CS(=O)(=O)c2ccccc2)ccc(-c2ccoc2)c1O,CN(C)c1ccncc1,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20090105259A1,CC(C)(C)OC(=O)N[C@@H]1CCCNC1.O=C=Nc1ccccc1>>N[C@@H]1CCCN(C(=O)Nc2ccccc2)C1,,ClCCl,,,,val
US07531506B2,CC(C)(C)OC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)OCC(Cl)(Cl)Cl>>O=C(N[C@@H](CO)C(=O)OCC(Cl)(Cl)Cl)OCC1c2ccccc2-c2ccccc21,,O,O=C(O)C(F)(F)F,,,val
US20070185155A1,CCCCCCCCCBr.OC(c1ccccc1)(c1ccccc1)C12CCN(CC1)CC2>>CCCCCCCCC[N+]12CCC(C(O)(c3ccccc3)c3ccccc3)(CC1)CC2.[Br-],,CC#N,,,,val
US20100210696A1,CCOC(C)=O.CCOC(C)=O.COc1cccc(S(=O)c2sc(CN(C)C(=O)OC(C)(C)C)cc2-c2ccccc2F)c1>>CNCc1cc(-c2ccccc2F)c(S(=O)c2cccc(OC)c2)s1.O=C(O)/C=C/C(=O)O,,CCO,,Cl,,val
US20070232627A1,CC(C)c1ccc2c(Nc3cc(C(=O)N[C@@H](C)c4ccccc4)ccc3Sc3ccc(N)cc3)ncnc2n1.CS(=O)(=O)Cl>>CC(C)c1ccc2c(Nc3cc(C(=O)N[C@@H](C)c4ccccc4)ccc3Sc3ccc(NS(C)(=O)=O)cc3)ncnc2n1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US07202221B2,CC(C)(C)OC(=O)NCCN.O=C(O)c1cn(C2CC2)c2cc(Cl)c(F)cc2c1=O>>CC(C)(C)OC(=O)NCCNc1cc2c(cc1F)c(=O)c(C(=O)O)cn2C1CC1,,CS(C)=O,,CC(=O)O,,val
US20080171756A1,CC(C)(C)c1ccc(Cn2c(-c3c(Br)cccc3Br)nc(O)c(C(=O)NCC(=O)O)c2=O)cc1.OB(O)c1ccccc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)c1ccc(Cn2c(-c3c(-c4ccccc4)cccc3-c3ccccc3)nc(O)c(C(=O)NCC(=O)O)c2=O)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,[Na+].[OH-],,val
US20070219186A1,Nc1cc(C(=O)Nc2cccc(-c3ccnc4cc(-c5ccncc5)nn34)c2)cc(C(F)(F)F)c1.O=C(Cl)CCl>>O=C(CCl)Nc1cc(C(=O)Nc2cccc(-c3ccnc4cc(-c5ccncc5)nn34)c2)cc(C(F)(F)F)c1,,CN(C)C=O,ClCCl,c1ccncc1,,val
US20110021537A1,CCOC(=O)N1CCN(C(=O)[C@@H](N)CC(=O)OC(C)(C)C)CC1.CN(C)C=O.O=C(O)c1cc(O)n(-c2cccc(F)c2)n1>>CCOC(=O)N1CCN(C(=O)[C@@H](NC(=O)c2cc(O)n(-c3cccc(F)c3)n2)C(C)C(=O)OC(C)(C)C)CC1,,CCN(C(C)C)C(C)C,CN(C)C=O,ClCCCl,,val
US20110034450A1,Cc1ccc([C@@H](C(=O)OC(C)(C)C)C2CCCC2)cc1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)[C@H](c1ccc(CBr)cc1)C1CCCC1,,ClC(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20100234521A1,C=CCCCCCCCCCO.FC(F)(F)C(F)(F)C(F)(F)C(F)(F)I>>OCCCCCCCCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F,[Zn],CCO,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20120010188A1,Nc1ncccn1.O=C(CCl)c1ccc(Cl)cc1Cl>>Clc1ccc(-c2cn3cccnc3n2)c(Cl)c1,,CCO,,[Na+].[OH-],,val
US06284913B1,CS(=O)(=O)O.N#Cc1ccc(C#N)cc1>>CS(=O)(=O)[O-].N#Cc1ccc(C[NH3+])cc1,[Pd],CC(C)O,,[H][H],,val
US04683241,CC(C)(C)C(=O)Cl.O.Oc1ccc(N=Nc2ccc(O)cc2)cc1.c1ccncc1>>CC(C)(C)C(=O)Oc1ccc(N=Nc2ccc(OC(=O)C(C)(C)C)cc2)cc1,,c1ccncc1,,N#N,,val
US06376665B1,COC(=O)C(CC(=O)OC(C)(C)C)c1ccc(OCc2ccccc2)cc1>>CC(C)(C)OC(=O)CC(C(=O)O)c1ccc(OCc2ccccc2)cc1,,CO,,[Li+].[OH-],,val
US20040077622A1,OCc1cc2c(o1)CCC2>>O=Cc1cc2c(o1)CCC2,O=[Mn]=O,ClC(Cl)Cl,,,,val
US20040110764A1,C[Si](C)(C)CCOCn1ccnc1C=CC(=O)c1ccc(C#N)cc1>>C[Si](C)(C)CCOCn1ccnc1C=CC(O)c1ccc(C#N)cc1,,CO,,[BH4-].[Na+],,val
US20040133011A1,NNC(=O)c1ccc(OCc2ccccc2)cc1C(F)(F)F.O=C(O)C12CCC(c3ccccc3)(CC1)CC2>>O=C(NNC(=O)C12CCC(c3ccccc3)(CC1)CC2)c1ccc(OCc2ccccc2)cc1C(F)(F)F,CN(C)C=O,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20150148340A1,CCNc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>CCNc1ccc([N+](=O)[O-])cc1N,[Pd],CC#N,,CCN(CC)CC,O=CO,val
US20130317231A1,COc1ccc(/C=C\c2cc(OC)c(OC)c(OC)c2)cc1OCC(=O)O.Nc1nc2ccccc2s1>>COc1ccc(/C=C\c2cc(OC)c(OC)c(OC)c2)cc1OCC(=O)Nc1nc2ccccc2s1,,ClCCl,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20130267556A1,CCOC(=O)c1cc2cc(Cl)ncc2n1CCCCF>>OCc1cc2cc(Cl)ncc2n1CCCCF,,C1CCOC1,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20120277224A1,COC(=O)CC(=O)c1ccc(O)cc1.Cc1n[nH]c(N)c1-c1ccccc1>>Cc1nn2c(=O)cc(-c3ccc(O)cc3)[nH]c2c1-c1ccccc1,,CC(=O)O,,,,val
US20130244993A1,C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O.O=C(O)C(F)(F)F.OC1CN(c2ncc(Br)cn2)C1>>C[C@@H](c1ccc(-c2cnc(N3CC(O)C3)nc2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O.O=C(O)C(F)(F)F,,C1COCCO1,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05763437,Nc1cccc(O)c1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>O=C(Nc1cccc(O)c1)Oc1ccc([N+](=O)[O-])cc1,,C1CCOC1,CCOC(C)=O,Cl,c1ccncc1,val
US04632927,CNN.CSC(=NCCCOc1cccc2c(N3CCOCC3)nccc12)NC#N>>Cn1nc(N)nc1NCCCOc1cccc2c(N3CCOCC3)nccc12,,CN(C)C=O,,,,val
US04005096,COc1ccccc1OCCN.O=Cc1cccnc1>>COc1ccccc1OCCNCc1cccnc1,,CO,,[BH4-].[Na+],,val
US20120178736A1,CC(C)(C)OC(=O)N1CCNCC1.C[C@H](O)C(=O)O>>CC(O)C(=O)N1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US05391541,BrP(Br)Br.O=[N+]([O-])c1cc(Cl)c(Cl)c(CO)c1>>O=[N+]([O-])c1cc(Cl)c(Cl)c(CBr)c1,,Cc1ccccc1,,,,val
US20060281772A1,CC(C)c1ccc(NC(=O)Oc2ccc([N+](=O)[O-])cc2)cc1.c1ccc2c(C3CCNCC3)ccnc2c1>>CC(C)c1ccc(NC(=O)N2CCC(c3ccnc4ccccc34)CC2)cc1,,CS(C)=O,,CCN(C(C)C)C(C)C,O=C([O-])[O-].[K+].[K+],val
US20090036422A1,COc1ccc(NC(=O)Cc2ccc(C(F)(F)F)cc2)cc1OC>>COc1ccc(NCCc2ccc(C(F)(F)F)cc2)cc1OC,,C1CCOC1,,B,,val
US20160185727A1,CCOC(=O)CC(C)=O.C[C@@H]1CC[C@@H](Oc2cccc(N)c2C#N)CC1>>CCOC(=O)c1c(C)nc2cccc(O[C@@H]3CC[C@@H](C)CC3)c2c1N,,Cc1ccccc1,,Cl[Sn](Cl)(Cl)Cl,,val
US20040209886A1,CCOC(=O)c1ccc(C(=O)OCC)n1N.COC(OC)N(C)C>>CCOC(=O)c1ccc(C(=O)OCC)n1N=CN(C)C,,CN(C)C=O,,,,val
US20050020566A1,CN=C=O.C[C@@H](O[Si](C)(C)C)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(c3cccc(O)c3)C[C@H]12>>CNC(=O)Oc1cccc(C2=C(C(=O)OCc3ccc([N+](=O)[O-])cc3)N3C(=O)[C@H]([C@@H](C)O[Si](C)(C)C)[C@H]3C2)c1,,ClCCl,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US04720495,CCOC(=O)c1cn2c3c(c(N4CCNC(C)C4)c(Cl)cc3c1=O)C=CC2C>>CC1CN(c2c(Cl)cc3c(=O)c(C(=O)O)cn4c3c2C=CC4C)CCN1,,CCO,,Cl,[Na+].[OH-],val
US20080166359A1,C1COCCO1.CC(C)(C)OC(=O)N1CCCC[C@H]1C1(O)CN(C(=O)c2ccncc2Nc2ccc(I)cc2F)C1>>CC(=O)OC1([C@@H]2CCCCN2)CN(C(=O)c2ccncc2Nc2ccc(I)cc2F)C1,,CO,,Cl,,val
US05686424,CC(Br)C(=O)c1ccccc1.CC[C@H](C)[C@H](N)C(=O)NCc1ccccc1.O=C(O)[C@@H]1CCCN1>>CC[C@H](C)[C@H](N)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1C(C)C(=O)c1ccccc1,,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US20120309735A1,CC(=O)Nc1cc(-c2cnc(N3CCCNC(=O)C3)s2)cc(N(C(=O)OC(C)(C)C)c2nccc(C(F)(F)F)n2)c1>>CC(=O)Nc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(N3CCCNC(=O)C3)s2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150197498A1,O=[N+]([O-])c1ccc2oc(-c3ccc(-c4ccc(C(F)(F)F)cc4)cc3)nc2c1>>Nc1ccc2oc(-c3ccc(-c4ccc(C(F)(F)F)cc4)cc3)nc2c1,[Pd],CCOC(C)=O,CO,,,val
US20120208815A1,O=[N+]([O-])c1cnccc1C1=CCCCC1>>Nc1cnccc1C1=CCCCC1,[Fe],CC(=O)O,,,,val
US20030181468A1,CN1CCNCC1.Nc1ncnc2sc(CBr)c(-c3ccc([N+](=O)[O-])cc3)c12>>CN1CCN(Cc2sc3ncnc(N)c3c2-c2ccc([N+](=O)[O-])cc2)CC1,,CN(C)C=O,,,,val
US03996374,CCOC(=O)c1c2ccc(Cl)cc2c(-c2ccccc2)n1CC(=O)N(CC)CC.Cl>>CCOC(=O)c1c2ccc(Cl)cc2c(-c2ccccc2)n1CCN(CC)CC.Cl,,C1CCOC1,,B,,val
US20110144068A1,Brc1cccc(-c2n[nH]cc2-c2ccncc2)c1.COc1ccc(CCl)cc1>>COc1ccc(Cn2cc(-c3ccncc3)c(-c3cccc(Br)c3)n2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140275015A1,O=C(Cl)c1cccc2c1OC(F)(F)O2.c1ccc(-n2cnc3c2CCNC3)cc1>>O=C(c1cccc2c1OC(F)(F)O2)N1CCc2c(ncn2-c2ccccc2)C1,,ClC(Cl)Cl,,,,val
US20120046271A1,Cc1nnc(Br)s1.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>Cc1nncs1.O=C(O)[C@H](O)[C@@H](O)C(=O)O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20100087429A1,CC(C)(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(Br)cnc1O2.OB(O)c1cccnc1>>CC(C)(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cccnc3)cnc1O2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US20030176450A1,CC(=O)c1ccccn1.CCOC(=O)C(F)(F)F>>O=C(CC(=O)C(F)(F)F)c1ccccn1,,CO,,C[O-].[Na+],,val
US07452906B2,N#CCBr.ON=C1CCc2cc(-c3oc(C4CCNCC4)cc3-c3ccncc3)ccc21>>N#CCN1CCC(c2cc(-c3ccncc3)c(-c3ccc4c(c3)CCC4=NO)o2)CC1,,CN(C)C=O,ClCCl,CCN(CC)CC,,val
US20020019371A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)Cc1cccc(N)c1>>CCOC(=O)Cc1cccc(NC(=O)OC(C)(C)C)c1,,C1CCOC1,,,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3cc(OC)ccc3OC)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)Nc3cc(OC)ccc3OC)c2)=C(C)C1=O,,CO,O,O=C([O-])O.[Na+],,val
US05409943,CCOC(=N)Cc1ccccc1Cl.Cl.Nc1ncccc1OCc1c(F)cccc1Cl>>Cl.N=C(Cc1ccccc1Cl)Nc1ncccc1OCc1c(F)cccc1Cl,,CCO,,,,val
US05849958,CC(C)(C#N)c1ccc(Cl)cc1.O>>CC(C)(C=O)c1ccc(Cl)cc1,,CCCCCC,CCOCC,Cl,CC(C)C[Al+]CC(C)C.[H-],val
US05347030,CCOC(=O)CCCCCCCCCC=Cc1cccc([N+](=O)[O-])c1>>CCOC(=O)CCCCCCCCCCCc1cccc(N)c1,[Pd],CCOC(C)=O,,,,val
US20030032657A1,CSc1c(F)cc(CC(=O)c2ccccc2)cc1F.NO>>CSc1c(F)cc(CC(=NO)c2ccccc2)cc1F,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20090023716A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.CC1(C)Oc2cc(N)cc(Br)c2N(c2ccc(F)cc2)C1=O>>C=C(OCC)c1cc(N)cc2c1N(c1ccc(F)cc1)C(=O)C(C)(C)O2,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,,,,val
US20070129408A1,C[C@@H](Oc1nnc(-c2ccncc2)n1C)c1cc(-c2cccc(Cl)c2)on1.O=S(=O)(O)O>>C[C@@H](Oc1nnc(-c2ccncc2)n1C)c1cc(-c2cccc(Cl)c2)on1.O=S(=O)(O)O,,CO,,O,,val
US20030171303A1,CC(C)C=O.SCCCS>>CC(C)C1SCCCS1,,ClCCl,,CCOCC,FB(F)F,val
US20100209340A1,C=CC(=O)OCC.CCN(CC)CC.CCNc1nc(N)nc(C)c1I.CN(C)C=O>>CCOC(=O)/C=C/c1c(C)nc(N)nc1NC1CCOC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,,val
US06060432,O=C1[C@H]2C[C@@H](O)CN2C(=O)N1c1cc(NS(=O)(=O)CCl)c(Cl)cc1F.O=S(Cl)Cl>>O=C1[C@H]2C[C@H](Cl)CN2C(=O)N1c1cc(NS(=O)(=O)CCl)c(Cl)cc1F,,Cc1ccccc1,,CN(C)C=O,,val
US20070004761A1,CI.Nc1nc(Cl)cc(=O)[nH]1>>Cn1c(N)nc(Cl)cc1=O,,CCO,,[Na+].[OH-],,val
US20080161302A1,O=[N+]([O-])c1ccc(Nc2ccccn2)cc1>>Nc1ccc(Nc2ccccn2)cc1,,CCOC(C)=O,,,,val
US20050282843A1,CC(=O)c1c(C)c[nH]c1C.O=C=NS(=O)(=O)Cl>>CC(=O)c1c(C)[nH]c(C#N)c1C,,CC#N,CN(C)C=O,,,val
US20060052315A1,Cc1cccc(I)c1C.O=Cc1ccc(B(O)O)cc1>>Cc1cccc(-c2ccc(C=O)cc2)c1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20090042925A1,CC(C)C(=O)NCCCn1c(CCl)nc2c(N)nc3cccnc3c21.O=C1c2ccccc2C(=O)N1O>>CC(C)C(=O)NCCCn1c(CON2C(=O)c3ccccc3C2=O)nc2c(N)nc3cccnc3c21,,CN(C)C=O,,CCN(CC)CC,,val
US20150112063A1,COc1cc(OC)nc(NC(=O)Oc2ccccc2)n1.Cn1nnc(-c2cnn(C)c2S(N)(=O)=O)n1>>COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2c(-c3nnn(C)n3)cnn2C)n1,,CC#N,O,CCN(CC)CC,Cl,val
US05216105,O=S(=O)(Cl)c1cccc2ccccc12>>O=S(O)c1cccc2ccccc12,,O,,O=S([O-])[O-].[Na+].[Na+],,val
US04855086,O=CC=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=CCCC#Cc1ccccc1>>O=C/C=C/CCC#Cc1ccccc1,,ClCCl,,,,val
US20110118251A1,CI.OCc1cccnc1Br>>COCc1cccnc1Br,,C1CCOC1,,[H-].[Na+],,val
US20090054465A1,COC(=O)/C=C/c1cnc(N[C@@H]2CCN(CCc3cccc(F)c3)C2)cn1>>O=C(O)/C=C/c1cnc(N[C@@H]2CCN(CCc3cccc(F)c3)C2)cn1,,CO,,Cl,[Na+].[OH-],val
US20120077797A1,Brc1ncccn1.CC(C)(C)OC(=O)N1CCNC(=O)C1>>CC(C)(C)OC(=O)N1CCN(c2ncccn2)C(=O)C1,,CN(C)C=O,,O,[H-].[Na+],val
US20100204196A1,CCCN(CCC)[C@@H](C)C(=O)N1CCc2cc(OC)c([N+](=O)[O-])cc21>>CCCN(CCC)[C@@H](C)C(=O)N1CCc2cc(OC)c(N)cc21,[Pd],CCO,,,,val
US20040259923A1,CC(=O)Nc1nc(-c2ccc(S(=O)[O-])cc2)cs1.OCCBr>>CC(=O)Nc1nc(-c2ccc(S(=O)(=O)CCO)cc2)cs1,,CN(C)C=O,,CCOC(C)=O,O,val
US05629325,CC(C)(C)OC(=O)N1CC[C@H]1COc1cncc(Br)c1.OB(O)c1ccccc1>>CC(C)(C)OC(=O)N1CC[C@H]1COc1cncc(-c2ccccc2)c1,,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US04937240,CCCNCCC.Cc1nnc2n1-c1sc(CCC(=O)O)cc1C(c1ccccc1Cl)=NC2C>>CCCN(CCC)C(=O)CCc1cc2c(s1)-n1c(C)nnc1C(C)N=C2c1ccccc1Cl,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20060009439A1,CCOC(C)=O.CCOC(C)OC1CCC(C)(OC(C)OCC)C(O)C=CC(C)C(/C(C)=C/C=C/C(C)(CC2OC2C(C)C(CC)OC(C)OCC)OC(C)OCC)OC(=O)C1.ClCc1ccccc1>>CCOC(C)OC1CCC(C)(OC(C)OCC)C(OC(=O)c2ccccc2)C=CC(C)C(/C(C)=C/C=C/C(C)(CC2OC2C(C)C(CC)OC(C)OCC)OC(C)OCC)OC(=O)C1,,c1ccncc1,,,,val
US05679711,CC(C)(C)OC(=O)C(C)(C)O.O=C(O)CBr>>CC(C)(C)OC(=O)C(C)(C)OC(=O)CBr,,C1CCOC1,,,,val
US20070213349A1,Cc1ccnc(N)c1.Cc1cn(CC(=O)O)c(=O)[nH]c1=O>>Cc1ccnc(NC(=O)Cn2cc(C)c(=O)[nH]c2=O)c1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090286790A1,CCC1CC(=O)CC(COC)N1C(=O)OC(C)(C)C.NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CCC1CC(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(COC)N1C(=O)OC(C)(C)C,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150031627A1,Brc1cscn1.O=C1CC[C@@H](C(=O)N(c2cccc(F)c2)C(C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)N1>>O=C(NC1CC(F)(F)C1)[C@H](c1ccccc1Cl)N(C(=O)[C@@H]1CCC(=O)N1c1cscn1)c1cccc(F)c1,[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20150322074A1,CC(C)(C)OC(=O)N1CCC(F)(F)[C@@H](O)C1.Clc1ccc2ccccc2n1>>CC(C)(C)OC(=O)N1CCC(F)(F)[C@@H](Oc2ccc3ccccc3n2)C1,,CS(C)=O,,[H-].[Na+],,val
US20060100425A1,CC(C)(C)OC(=O)Cn1cc(C2NS(=O)(=O)c3ccccc32)c2cc(Cl)ccc21>>O=C(O)Cn1cc(C2NS(=O)(=O)c3ccccc32)c2cc(Cl)ccc21,,CCO,,[Na+].[OH-],,val
US20090036473A1,CC(C)c1nc2ccccc2c(=O)n1N.Cc1ccc(C2CC2C(=O)O)cc1F>>Cc1ccc([C@@H]2C[C@H]2C(=O)Nn2c(C(C)C)nc3ccccc3c2=O)cc1F,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20130237555A1,CC(C)C[C@@H](COc1ccc2c(c1)OC(C(F)(F)F)c1cnccc1-2)NC(=O)OC(C)(C)C.O=C1CCC(=O)N1Cl>>CC(C)C[C@@H](COc1cc2c(cc1Cl)-c1ccncc1C(C(F)(F)F)O2)NC(=O)OC(C)(C)C,,CC#N,,,,val
US04529548,CS[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](OC(C)=O)C[C@]12C>>CS[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C,,C1CCOC1,CO,,,val
US20150133428A1,CC(C)(C(=O)O)C(F)F.NC(=O)c1c(-c2ccc(Cl)c(Cl)c2)nn2c1CNCC2.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(NC(=O)N1CCn2nc(-c3ccc(Cl)c(Cl)c3)c(C(N)=O)c2C1)C(F)F,,CCOC(C)=O,Cc1ccccc1,C1CCOC1,,val
US20120252802A1,CC#N.CC(C)(O)Cc1cccc2ccccc12.O=S(=O)(O)O>>CC(=O)NC(C)(C)Cc1cccc2ccccc12,,O,,,,val
US20140163012A1,Cl.O=C1CN(CCc2ccc(F)cn2)CCN1c1ccc2c3c(oc2c1)CCCNC3>>Cl.O=C1CN(CCc2ccc(F)cn2)CCN1c1ccc2c3c(oc2c1)CCCNC3,,CO,,CCOCC,,val
US20120264734A1,C=O.CCN(c1cc(-c2ccc(N3CCNCC3)nc2)cc(C(=O)NCc2c(C(C)C)c(F)c(C)[nH]c2=O)c1C)C1CCOCC1.O.[BH3-]C#N>>CCN(c1cc(-c2ccc(N3CCN(C)CC3)nc2)cc(C(=O)NCc2c(C(C)C)c(F)c(C)[nH]c2=O)c1C)C1CCOCC1.O=CO,,CO,,Cl,,val
US20070043081A1,CCN(C1CCN(CCNC(=O)Nc2cc(C)nc(C)c2)CC1)S(=O)(=O)c1cc(Br)ccc1OC>>CCN(C1CCN(CCNC(=O)Nc2cc(C)nc(C)c2)CC1)S(=O)(=O)c1ccccc1OC,[Pd],CO,,,,val
US20090062353A1,O=C(NCCC(O)c1cccc(C#CC2(O)CCCCC2)c1)C(F)(F)F>>NCCC(O)c1cccc(C#CC2(O)CCCCC2)c1,,CO,O,,,val
US20030186969A1,COC(=O)c1ccc(N)c(CNCC(=O)OCCC(=O)c2ccc(Cl)cc2)c1.O=Cc1ccc(C(=O)N2CC=CC2)cc1>>COC(=O)c1ccc(NCc2ccc(C(=O)N3CC=CC3)cc2)c(CNCC(=O)OCCC(=O)c2ccc(Cl)cc2)c1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20090233937A1,O=[N+]([O-])c1ccc(F)c(C(F)(F)F)c1.Oc1cccc2sncc12>>Nc1ccc(Oc2cccc3sncc23)c(C(F)(F)F)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060235013A1,CCC1(CC)C(=O)N(C(C)C)c2cc([N+](=O)[O-])c(NC(C)=O)cc21>>CCC1(CC)C(=O)N(C(C)C)c2cc([N+](=O)[O-])c(N)cc21,,CCO,,Cl,,val
US06160003,Cc1ccccc1C(=O)Cl.Cn1cccc1CC#N>>Cc1ccccc1C(=O)c1ccc(CC#N)n1C,,ClCCl,,,,val
US20030060474A1,CCOC(C)=O.CN(C)C=O.O=C(O)c1cc(S)c2ccc(Cl)cc2n1>>COC(=O)c1cc(SC)c2ccc(Cl)cc2n1,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US05411933,C#CC(O)Br.Cc1ccc(S(=O)(=O)Cl)cc1>>C#CC(Br)OS(=O)(=O)c1ccc(C)cc1,,C1CCOC1,O,[Na+].[OH-],,val
US20110306612A1,Cn1c(-c2cccc(C(F)(F)F)c2)nc2c(N)cccc2c1=O.O=S(=O)(Cl)c1cccnc1>>Cn1c(-c2ccccc2)nc2c(NS(=O)(=O)c3cccnc3)cccc2c1=O,,c1ccncc1,,Cl,,val
US20120220665A1,CCOC(=O)NCC(c1ccccc1)C(O)c1cccc2ccccc12>>CNCC(c1ccccc1)C(O)c1cccc2ccccc12,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030036557A1,Cc1cncc(C2=NC(O)(C(F)(F)F)CN2c2ccc(S(C)(=O)=O)cc2)c1>>Cc1cncc(-c2nc(C(F)(F)F)cn2-c2ccc(S(C)(=O)=O)cc2)c1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US05723614,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1cc2cc(N3CCNCC3)ccc2o1>>CCOC(=O)c1cc2cc(N3CCN(C(=O)OC(C)(C)C)CC3)ccc2o1,,C1CCOC1,,,,val
US05389641,CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2C#N)cc1.C[Sn](C)(C)N=[N+]=[N-]>>CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1,,Cc1ccccc1,,,,val
US20090286836A1,Cc1cc(F)ccc1-c1cc([C@@H]2CC[C@](C)(C(N)=O)N2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl>>Cc1cc(F)ccc1-c1cc([C@@H]2CC[C@](C)(C(N)=O)N2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl,,CCOCC,,,,val
US20040242573A1,Cc1ccc(S(=O)(=O)Oc2ccc(Br)c(O)c2)cc1.ClCCN1CCCCC1>>Cc1ccc(S(=O)(=O)Oc2ccc(Br)c(OCCN3CCCCC3)c2)cc1,,CC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20110269956A1,CC(C)(C)OC(=O)N1CCCC1c1nc2cc(-c3ccc4cc(-c5ccc6nc(C7CCCN7C(=O)OC(C)(C)C)[nH]c6c5)ccc4c3)ccc2[nH]1>>c1cc2cc(-c3ccc4[nH]c(C5CCCN5)nc4c3)ccc2cc1-c1ccc2[nH]c(C3CCCN3)nc2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04276417,Nc1nc(N)nc(N2CC=CCC2)n1.O=C(OO)c1cccc(Cl)c1>>Nc1nc(N2CC=CCC2)nc(N)[n+]1[O-],,COCCOC,,,,val
US20030134843A1,CC(=O)c1ccccc1Br.CCOC(=O)c1cccnc1N>>CCOC(=O)c1cccn2cc(-c3ccccc3)nc12,,CC(C)=O,,,,val
US05076832,Nc1cccc(C(F)(F)F)c1.O=Cc1ccccc1F>>Fc1ccccc1C=Nc1cccc(C(F)(F)F)c1,,Cc1ccccc1,,,,val
US20030232860A1,CC1(C)OCC(CO)O1.CC1(C)OCC(COc2cccc(N)c2-c2ncc(C#N)cc2C#N)O1.N#Cc1cc(C#N)c(Cl)nc1N>>N#Cc1c(N)nc(OCC(O)CO)c(C#N)c1-c1ccccc1,,CCO,,Cl,,val
US20110046378A1,COCOc1ccc(C(=O)/C=C/c2ccc(OCc3ccccc3)c(OCOC)c2)c(O)c1.OO>>COCOc1ccc2c(=O)c(O)c(-c3ccc(OCc4ccccc4)c(OCOC)c3)oc2c1,,CO,,[Na+].[OH-],,val
US20150057260A1,CCCC[Sn](CCCC)(CCCC)c1cnccn1.CCOC(=O)c1cc(Cl)nc(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)n1>>CCOC(=O)c1cc(-c2cnccn2)nc(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,,,val
US06492416B1,CSc1ccc(C2=C(c3ccccc3)C(=O)C(C)(C)O2)c(Cl)c1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ccc(C2=C(c3ccccc3)C(=O)C(C)(C)O2)c(Cl)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US20140309193A1,CCOC(=O)c1c(OCc2ccccc2)c(OCc2ccccc2)c(C#N)n1-c1ccc(F)cc1>>CCOC(=O)c1c(O)c(O)c(C#N)n1-c1ccc(F)cc1,[Pd],C1CCOC1,,,,val
US20150329538A1,Clc1cnc2cccc(Cl)c2n1.Oc1ccccc1>>Clc1cccc2ncc(Oc3ccccc3)nc12,,C1CCOC1,,[H-].[Na+],,val
US20080045528A1,CI.Oc1ccc2nc(S)sc2c1>>CSc1nc2ccc(O)cc2s1,,ClCCl,,CCN(CC)CC,,val
US05166198,C=CCCP(=O)(OCC)OCC.C[N+]1([O-])CCOCC1.O=[Os](=O)(=O)=O>>CCOP(=O)(CCC(O)CO)OCC,O=[Os](=O)(=O)=O,O,,CC(C)=O,,val
US20100075952A1,O=C1Cc2ccccc2N1.O=S(=O)(O)Cl>>O=C1C=c2cc(S(=O)(=O)Cl)ccc2=N1,,O,,,,val
US07030118B2,CCC(O)c1nn2ccc(C(=O)OC)c2c(=O)n1Cc1ccccc1.CS(=O)(=O)Cl>>CCC(OS(C)(=O)=O)c1nn2ccc(C(=O)OC)c2c(=O)n1Cc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US04228167,CCCCN1C2=NCCN2C(O)(c2ccccc2)c2ccccc21>>CCCCN1C2=NCCN2C(c2ccccc2)c2ccccc21,,O=C(O)C(F)(F)F,,[BH4-].[Na+],,val
US20130109639A1,CCO.C[C@@](CO)(C[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)O>>CCOC(=O)[C@](C)(CO)C[C@H](N)Cc1ccc(-c2ccccc2)cc1,,C1COCCO1,,Cl,,val
US20050165063A1,CCCN(CCC)CCCCN(C)S(=O)(=O)c1ccc(CNCc2ncc[nH]2)cc1.Cn1ccnc1C=O>>CCCN(CCC)CCCCN(C)S(=O)(=O)c1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20140031360A1,CC(C)N.COc1ccc(COc2cc(-c3c[nH]c4ccc(-c5cncc(C6CC6)n5)cc34)nc(S(C)(=O)=O)n2)cc1>>COc1ccc(COc2cc(-c3c[nH]c4ccc(-c5cncc(C6CC6)n5)cc34)nc(NC(C)C)n2)cc1,,CN1CCCC1=O,O,,,val
US20050267149A1,CCCCCCN(Cc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2C(=O)OC)c(OC)c1>>CCCCCCN(Cc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2C(=O)O)c(OC)c1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20120172345A1,CCOC(=O)c1sc(N2CCOCC2)nc1C.O=C1CCC(=O)N1Br>>CCOC(=O)c1sc(N2CCOCC2)nc1CBr,CC(C)(C#N)N=NC(C)(C)C#N,,,ClCCl,,val
US20120323035A1,CC(C)(C)C(=O)Oc1ccccc1C(=O)O.O=S(Cl)Cl>>CC(C)(C)C(=O)Oc1ccccc1C(=O)Cl,c1ccncc1,ClCCl,,,,val
US20090221551A1,Cc1ccc(S(=O)(=O)Cl)cc1.c1ccc2c(c1)ncc1nc3cc[nH]n3c12>>Cc1ccc(S(=O)(=O)n2ccc3nc4cnc5ccccc5c4n32)cc1,,C1CCOC1,COC(C)(C)C,[H-].[Na+],,val
US20160226003A1,CC1(C)CC(C)(C)c2c1cnc1c2ccc2cc3ccccc3cc21.O=C1CCC(=O)N1Br>>CC1(C)CC(C)(C)c2c1cnc1c2ccc2c(Br)c3ccccc3cc21,,CN(C)C=O,,,,val
US20060046977A1,O=C(Cl)C(=O)Cl.O=c1cc[nH]c2oc(-c3ccc(O)cc3)c(-c3ccccc3)c12>>Oc1ccc(-c2oc3nccc(Cl)c3c2-c2ccccc2)cc1,,CN(C)C=O,,ClC(Cl)Cl,,val
US03952033,C[C@@H](CBr)CCC(=O)O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(CCC(=O)O)C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-],,CCOCC,,CC#N,,val
US20090048259A1,C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(CO)cc2)c2ccccc12.O=C=NC(=O)C(Cl)(Cl)Cl>>C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(COC(N)=O)cc2)c2ccccc12,,ClC(Cl)Cl,,,,val
US20080255105A1,CCOC(=O)c1ccc(B(O)O)cc1.COc1ccc(C(=O)Nc2ccc(N3CCOCC3)cc2C)cc1Br>>COc1ccc(C(=O)Nc2ccc(N3CCOCC3)cc2C)cc1-c1ccc(C(=O)O)cc1,,O,,COCCOC,O=C([O-])[O-].[Cs+].[Cs+],val
US20070066641A1,COc1cccc(C(=O)c2c[nH]c3ncc(Nc4ccccc4)cc23)c1>>O=C(c1cccc(O)c1)c1c[nH]c2ncc(Nc3ccccc3)cc12,,ClCCl,,BrB(Br)Br,,val
US20080255197A1,COC(=O)c1ccc(CBr)c(C(=O)OC)c1.Cc1cnc(CN[C@H]2CCCc3cccnc32)c(C)c1>>COC(=O)c1ccc(CN(Cc2ncc(C)cc2C)C2CCCc3cccnc32)c(C(=O)OC)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20110009454A1,NCc1ccc(Oc2cccc(OC(F)(F)F)c2)cc1.Nc1nc(F)ccc1C(=O)O>>Nc1nc(F)ccc1C(=O)NCc1ccc(Oc2cccc(OC(F)(F)F)c2)cc1,,CN(C)C=O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20060178376A1,CCCCCN.O=CNc1cccc([N+](=O)[O-])c1C=O>>CCCCCN1C=Nc2cccc([N+](=O)[O-])c2C1O,,CCO,,,,val
US20160166560A1,COc1ccc(CN2CCC(N(C)C(=O)n3cnc(-c4cccc(C(N)=O)c4)c3)CC2)cc1.Cl>>COc1ccc(CN2CCC(N(C)C(=O)n3cnc(-c4cccc(C(N)=O)c4)c3)CC2)cc1.Cl,,CO,,CCOCC,,val
US20150038528A1,CC(C)(C)OC(=O)N[C@@H](CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(=O)O.O=C(O)C(F)(F)F>>N#Cc1nc(C(=O)NCC[C@H](N)C(=O)O)c(O)c2ccc(Oc3ccccc3)cc12.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05959107,O=[N+]([O-])c1ccc(Sc2cccc3cnccc23)cc1NCc1ccccc1>>Nc1ccc(Sc2cccc3cnccc23)cc1NCc1ccccc1,,Cl,,[Cl-].[Na+],,val
US20110046122A1,CC1(c2cc(NC(=O)c3ccc(Cl)cc3)ccc2F)COCC(N)=N1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC1(c2cc(NC(=S)c3ccc(Cl)cc3)ccc2F)COCC(N)=N1,,COCCOC,,,,val
US03931204,CC(C)N.Clc1nc(Cl)c2cscc2n1>>CC(C)Nc1nc(Cl)nc2cscc12,,CCO,,,,val
US05883049,CC(=O)C(C)Cl.O=C1C2=CCCCN2C(=O)N1c1cc(O)c(Cl)cc1F>>CC(=O)C(C)Oc1cc(N2C(=O)C3=CCCCN3C2=O)c(F)cc1Cl,,CC#N,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US05093027,CCCCC[C@@H]1CC[C@@H](CCC=Cc2ccc(C#N)cc2)CC1>>CCCCC[C@@H]1CC[C@@H](CCCCc2ccc(C#N)cc2)CC1,[Pd],CCOC(C)=O,,[H][H],,val
US20150232443A1,CCOC(=O)C1CCN(C2CC3(CCN(C(=O)OCC)C3)C2)CC1>>CCOC(=O)N1CCC2(CC(N3CCC(C(=O)O)CC3)C2)C1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20090005416A1,CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)c2ccc3c(c2)OCCO3)C[C@@H]1C(=O)O.Cc1ccc(N)c(N)c1>>Cc1ccc(NC(=O)[C@H]2C[C@H](NC(=O)c3ccc4c(c3)OCCO4)CCN2C(=O)OC(C)(C)C)c(N)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20070049632A1,CCI.COc1ccc(-n2[nH]c3c(c2=O)[C@H]2CC[C@]3(C)C2(C)C)cc1>>CCn1c2c(c(=O)n1-c1ccc(OC)cc1)[C@H]1CC[C@]2(C)C1(C)C,,CN(C)C=O,ClCCl,,,val
US20080103129A1,O=C1C(S(=O)(=O)c2ccc(-c3nc4cc(C(F)(F)F)ccc4[nH]3)cc2)CCCCN1OC(c1ccccc1)(c1ccccc1)c1ccccc1>>O=C1C(S(=O)(=O)c2ccc(-c3nc4cc(C(F)(F)F)ccc4[nH]3)cc2)CCCCN1O,,ClCCl,,O=C(O)C(F)(F)F,,val
US05990106,CC(C)(C)OC(=O)NC12CCC1CNC2.O=C(O)c1cn(C2CC2)c2c(Cl)c(F)c(F)cc2c1=O>>CC(C)(C)OC(=O)NC12CCC1CN(c1c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c1Cl)C2,,CC#N,,C1CCC2=NCCCN2CC1,,val
US05556981,Cc1cccc(-c2ccccc2C#N)c1.O=[N+]([O-])O>>Cc1cc(-c2ccccc2C#N)ccc1[N+](=O)[O-],,O,,O=S(=O)(O)O,,val
US20010027196A1,C=Cc1ccc(CNc2nc(N)nc(-c3ccco3)c2C#N)cc1>>CCc1ccc(CNc2nc(N)nc(-c3ccco3)c2C#N)cc1,[Pd],CCO,,[H][H],,val
US20130116234A1,CC(C)c1cccc(-c2c(C#N)c(=O)[nH]c3ccc(Cl)cc23)c1.O=P(Cl)(Cl)Cl>>CC(C)c1cccc(-c2c(C#N)c(Cl)nc3ccc(Cl)cc23)c1,,O,,,,val
US20090042929A1,CC1(C(=O)O)CC1.CNCc1cccs1>>CN(Cc1cccs1)C(=O)C1(C)CC1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US20130053384A1,CCCS(=O)(=O)N(c1cc(F)c(F)c(C(=O)c2ccc3ncc(Cl)nc3c2)c1F)S(=O)(=O)CCC.Cc1ncc[nH]1>>CCCS(=O)(=O)Nc1cc(F)c(F)c(C(=O)c2ccc3ncc(-n4ccnc4C)nc3c2)c1F,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030036651A1,CCOC(=O)CCCCc1ccncc1.CSc1cccc(Nc2nc(C)ccc2C=O)c1>>CSc1cccc(-n2c(=O)c(CCCc3ccncc3)cc3ccc(C)nc32)c1,,CCOC(C)=O,,CC(C)[N-]C(C)C.[Li+],,val
US20050130954A1,CC(C)(C)OC(=O)N1CCNCC1.Cc1ccc2c(Cl)ncnc2n1>>Cc1ccc2c(N3CCN(C(=O)OC(C)(C)C)CC3)ncnc2n1,,ClCCCl,,,,val
US20150376191A1,NCCCN1c2ccccc2CCc2ncccc21.O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>O=S(=O)(NCCCN1c2ccccc2CCc2ncccc21)c1ccc(OC(F)(F)F)cc1,,CN(C)C=O,,CCN(CC)CC,,val
US20130316906A1,CCc1cc(C)cc(CC)c1C1C(=O)C2CC(CCCC=O)CC2C1=O.CON>>CCc1cc(C)cc(CC)c1C1C(=O)C2CC(CCC(C)=NOC)CC2C1=O,,CC#N,CCOC(C)=O,CCN(CC)CC,Cl,val
US20100029617A1,O=C(O)CC(=O)O.O=Cc1ccc(C(F)(F)F)cc1F>>O=C(O)C=Cc1ccc(C(F)(F)F)cc1F,,O,c1ccncc1,C1CCNCC1,Cl,val
US20010021718A1,CCOC(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1.COC(=O)CN>>COC(=O)CNC(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1,,CCO,,CCN(CC)CC,Cl,val
US04147804,CCc1cccc(CC)c1N.Cc1ccc(S(=O)(=O)Cl)cc1>>CCc1cccc(CC)c1NS(=O)(=O)c1ccc(C)cc1,,c1ccncc1,,Cl,,val
US20160244437A1,CN(C)C(=O)c1cccc(-c2cccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CNC(=O)OC(C)(C)C)CC3)C(=O)Nc3ccc(-c4nnn[nH]4)cc3)c2)c1.Cl>>CN(C)C(=O)c1cccc(-c2cccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CN)CC3)C(=O)Nc3ccc(-c4nnn[nH]4)cc3)c2)c1.Cl,,C1COCCO1,,CC#N,,val
US20040242584A1,CC(=O)N(C)Cc1ccc(F)cc1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(=S)N(C)Cc1ccc(F)cc1,,Cc1ccccc1,,,,val
US08906135B1,CCCn1cc(C[Si](C)(C)C)nn1.CI>>CCCn1cc(C[Si](C)(C)C)[n+](C)n1.[I-],,CC#N,,,,val
US20090042896A1,CON(C)C(=O)[C@H]1CN(Cc2ccccc2)C[C@@H]1c1ccc(Cl)c(Cl)c1>>O=C[C@H]1CN(Cc2ccccc2)C[C@@H]1c1ccc(Cl)c(Cl)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070155839A1,CC(C)(C)OC(=O)/C=C/c1ccc(C(=C2C3CCCC2CCC3)c2ccc(O)cc2)cc1>>O=C(O)/C=C/c1ccc(C(=C2C3CCCC2CCC3)c2ccc(O)cc2)cc1,,Cc1ccccc1,ClCCl,O=C(O)C(F)(F)F,,val
US05922727,CC(C)(C)[Si](C)(C)OCC1C=C(CBr)CC1CO[Si](C)(C)C(C)(C)C.CCc1c(Sc2ccccc2)[nH]c(=O)[nH]c1=O>>CCc1c(Sc2ccccc2)n(CC2=CC(CO[Si](C)(C)C(C)(C)C)C(CO[Si](C)(C)C(C)(C)C)C2)c(=O)[nH]c1=O,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20090137561A1,C=C(c1cc(C(=O)OC)ccc1-c1cc(OC)ccc1F)C(C)(C)C.O=S(Cl)Cl>>C=C(c1cc(CCl)ccc1-c1cc(OC)ccc1F)C(C)(C)C,,ClCCl,,CN(C)C=O,,val
US20030096826A1,CON(C)C(=O)[C@H](CC(=O)OC(C)(C)C)NS(=O)(=O)c1ccccc1OCc1ccccc1>>CON(C)C(=O)[C@H](CC(=O)OC(C)(C)C)NS(=O)(=O)c1ccccc1O,[Pd],,,[H][H],,val
US20060235037A1,CN(CCC=O)C(=O)OC(C)(C)C.COc1ccccc1-c1cc2cc(C3CCNCC3)ccc2[nH]1>>CNCCCN1CCC(c2ccc3[nH]c(-c4ccccc4OC)cc3c2)CC1,,CCOC(C)=O,ClCCl,CC(=O)O,[Na],val
US20100311754A1,CCCCC=CB(O)O.O=C(Nc1ccc(Br)c2ccccc12)c1cc(F)cc(N2CCOCC2)c1>>CCCCC=Cc1ccc(NC(=O)c2cc(F)cc(N3CCOCC3)c2)c2ccccc12,,C1COCCO1,,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110039843A1,Nc1cc(C(F)(F)F)ccc1O.O=C(O)c1ccncc1Br>>O=C(Nc1cc(C(F)(F)F)ccc1O)c1ccncc1Br,,c1ccncc1,,CCN=C=NCCCN(C)C,,val
US20120316192A1,CCOC(=O)C#CC(=O)OCC.COc1ccc2[nH]cc(CCN)c2c1.O=Cc1coc2ccc(Cl)cc2c1=O>>CCOC(=O)C1=CC(C(=O)c2cc(Cl)ccc2O)=CN2CCc3c([nH]c4ccc(OC)cc34)C12C(=O)OCC,,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130150407A1,COC(=O)Cc1cc2ccc(F)cc2c(C2CCNCC2)c1C.O=S(=O)(Cl)Cc1ccccc1>>COC(=O)Cc1cc2ccc(F)cc2c(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)c1C,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US05441950,ClCCl.NCc1ccncc1.O=C(Cl)N1Cc2ccccc2Oc2ccc(Cl)cc21>>Cl.O=C(NCc1ccncc1)N1Cc2ccccc2Oc2ccc(Cl)cc21,,ClCCl,,CCN(CC)CC,,val
US04067874,C1CCNCC1.Cc1cc(Cl)cc(N)[n+]1[O-]>>Cc1cc(N2CCCCC2)cc(N)[n+]1[O-],,O,,Cl,,val
US20080312226A1,O=C(Nc1ccc(NC(=O)C(F)(F)F)cc1)OCC(Cl)(Cl)Cl.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>O=C(Nc1ccc(NC(=O)C(F)(F)F)cc1)N1CCN(c2nc(-c3ccccc3)ns2)CC1,,O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US20060247320A1,CC(C)(C)OC(=O)NC[C@@H](NC(=O)c1cc2cc3c(nc2s1)CC[C@@H](C(C)(C)C)C3)c1ccc(N)cc1.O=C(Cl)c1ccco1>>CC(C)(C)OC(=O)NC[C@@H](NC(=O)c1cc2cc3c(nc2s1)CC[C@@H](C(C)(C)C)C3)c1ccc(NC(=O)c2ccco2)cc1,,ClCCl,,CCN(CC)CC,CO,val
US20130225588A1,COC(=O)Cc1cc2ccc(F)cc2c(B2OC(C)(C)C(C)(C)O2)c1C.FC(F)(F)Oc1ccc(Sc2ccc(Br)cc2)cc1>>COC(=O)Cc1cc2ccc(F)cc2c(-c2ccc(Sc3ccc(OC(F)(F)F)cc3)cc2)c1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])O.[Na+],val
US05627182,COCCCOc1cc(C[C@@H](C[C@H]2[C@H](C[C@H](COCc3ccccc3)C(C)C)OC(C)(C)N2C(=O)OC(C)(C)C)C(C)C)ccc1OC>>COCCCOc1cc(C[C@@H](C[C@H]2[C@H](C[C@H](CO)C(C)C)OC(C)(C)N2C(=O)OC(C)(C)C)C(C)C)ccc1OC,[Pd],C1CCOC1,,,,val
US20100308754A1,O=[N+]([O-])c1ccc(F)cc1.c1ccc2c(c1)[nH]c1ccccc12>>O=[N+]([O-])c1ccc(-n2c3ccccc3c3ccccc32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20040102481A1,CN1CCC(c2c[nH]c3ccc(O)cc23)CC1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc([N+](=O)[O-])cc4)cc23)CC1,,C1CCOC1,,[Na+].[OH-],,val
US20150111889A1,COC(=O)C1Oc2ccc(Cl)cc2C(C2CCCCC2)(C2CCCCC2)O1.NN>>NNC(=O)C1Oc2ccc(Cl)cc2C(C2CCCCC2)(C2CCCCC2)O1,,CCO,,O,,val
US20050101647A1,COc1cccc(-c2nc3ccc(Br)cc3o2)c1>>Oc1cccc(-c2nc3ccc(Br)cc3o2)c1,,ClC(Cl)Cl,,BrB(Br)Br,O,val
US06057304,CCOC(=O)C(=O)O.Nc1cc([N+](=O)[O-])ccc1NCCC(=O)O>>O=C(O)CCn1c(=O)c(=O)[nH]c2cc([N+](=O)[O-])ccc21,,C1CCOC1,,CCN(CC)CC,,val
US20050130960A1,CC(Cn1ncc2ccc3c(c21)NC(=O)CO3)NC(=O)OC(C)(C)C.CI>>C[C@@H](Cn1ncc2ccc3c(c21)N(C)C(=O)CO3)NC(=O)OC(C)(C)C,,C1CCOC1,,CN(C)C=O,[H-].[Na+],val
US20120258953A1,N#CC1CCNCC1.O=C(Cl)N1CCOc2ccc(-c3ccc(-c4ncc[nH]4)nc3)cc2C1>>N#CC1CCN(C(=O)N2CCOc3ccc(-c4ccc(-c5ncc[nH]5)nc4)cc3C2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US20060135764A1,CS(=O)(=O)N1CCN(C[C@@H](O)CCl)CC1>>CS(=O)(=O)N1CCN(C[C@@H]2CO2)CC1,,C1CCOC1,O,[Na+].[OH-],,val
US20130029938A1,CCCC[C@]1(CC)CS(=O)(=O)c2cc(C=O)c(OC)cc2[C@@H](c2ccccc2)N1.CCOC(=O)CC(=O)OCC>>CCCC[C@]1(CC)CS(=O)(=O)c2cc(C=C(C(=O)OCC)C(=O)OCC)c(OC)cc2[C@@H](c2ccccc2)N1,,Cc1ccccc1,,C1CCNCC1,,val
US20120196872A1,BrCc1ccccc1.COC(=O)[C@@H](N)CC1CCCCCC1>>COC(=O)[C@H](CC1CCCCCC1)NCc1ccccc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130203735A1,N#CC1CCCN(c2ccc(F)cc2)C(=O)C1.NO>>NC(=NO)C1CCCN(c2ccc(F)cc2)C(=O)C1,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20150322079A1,C=CCCC(CC=C)OCc1ccccc1>>C1=CCC(OCc2ccccc2)CC1,,Cc1ccccc1,,,,val
US20080319188A1,CN1CCC(N(C)C(=O)Nc2cc(Oc3ccc(NC(=O)C4(C(=O)O)CC4)c(F)c3)ccn2)CC1.Nc1ccccc1>>CN1CCC(N(C)C(=O)Nc2cc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccccc5)CC4)c(F)c3)ccn2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20100292222A1,CC(C)(C)OC(=O)N1CCN(CCO)CC1.O=C(OCc1ccccc1)N1CC=C(c2ccc(O)cc2)CC1>>CC(C)(C)OC(=O)N1CCN(CCOc2ccc(C3=CCN(C(=O)OCc4ccccc4)CC3)cc2)CC1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070149508A1,COc1cccc(C=Cc2cnc(Nc3ccc(S(=O)(=O)C4CCN(C(=O)OC(C)(C)C)CC4)cc3)nc2)c1>>COc1cccc(C=Cc2cnc(Nc3ccc(S(=O)(=O)C4CCNCC4)cc3)nc2)c1,,ClCCl,,Cl,,val
US20090264416A1,CC(C)(C)NC(=O)c1cccc(CCl)c1.O=C(c1ccc([N+](=O)[O-])c(F)c1)N1CCNC(CF)C1>>CC(C)(C)NC(=O)c1cccc(CN2CCN(C(=O)c3ccc([N+](=O)[O-])c(F)c3)CC2CF)c1,,CC#N,,CCN(CC)CC,[I-].[Na+],val
US20130203076A1,COc1cccc(C2(c3ccccc3)CC(C)N(C)C2=N)c1.O=N[O-]>>COc1cccc(C2(c3ccccc3)CC(C)N(C)C2=O)c1,,O,,Cl,,val
US20160031871A1,CC(C)(C)OC(=O)Nc1ncc(CN2CCC(c3ccccc3)CC2)o1.CCI>>CCN(C(=O)OC(C)(C)C)c1ncc(CN2CCC(c3ccccc3)CC2)o1,,CN(C)C=O,,[H-].[Na+],,val
US20090286812A1,CC(C)c1noc([C@H]2CC[C@@H](NNC(=O)OC(C)(C)C)CC2)n1.O=Cc1c(Cl)ncnc1Cl>>CC(C)c1noc([C@@H]2CC[C@H](n3ncc4c(Cl)ncnc43)CC2)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20060217373A1,COCCOc1ccc(-c2c(C#N)c(N)nc(S)c2C#N)cc1.ClCc1csc(-c2ccsc2)n1>>COCCOc1ccc(-c2c(C#N)c(N)nc(SCc3csc(-c4ccsc4)n3)c2C#N)cc1,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20060270725A1,N=C(N)NN.S=C=Nc1ccc(C2CC2)c2ccccc12>>Nc1nnc(S)n1-c1ccc(C2CC2)c2ccccc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20030176441A1,COc1cccc(N=C=O)c1.Nc1ccccc1N1CCN(Cc2ccc(Cl)c(Cl)c2)CC1>>COc1cccc(NC(=O)Nc2ccccc2N2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)c1,,CCN(CC)CC,ClCCl,,,val
US20070072853A1,CCNc1ccc2c(c1)nc(C(C)(C)C)n2CC1CCOCC1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CCN(c1ccc2c(c1)nc(C(C)(C)C)n2CC1CCOCC1)S(=O)(=O)c1ccc([N+](=O)[O-])cc1,CN(C)c1ccncc1,CC#N,,Cl,,val
US20130178457A1,Cc1cccc2c(O)ccc(C(=O)N3CCOCC3)c12.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cccc2c(OS(=O)(=O)C(F)(F)F)ccc(C(=O)N3CCOCC3)c12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110105461A1,COCCN.Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(Cl)cc(S(C)(=O)=O)cc3O2)cc1>>COCCNC[C@H]1COc2c(Cl)cc(S(C)(=O)=O)cc2O1,,CC#N,,,,val
US04472579,CCOC(=O)c1cn(CC)c2cc(N3CCNCC3)c(F)cc2c1=O>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21,,CC(=O)O,,Cl,,val
US20160075713A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OCC(F)(F)c1ccc(C(F)(F)F)cn1>>O=S(=O)(OCC(F)(F)c1ccc(C(F)(F)F)cn1)C(F)(F)F,,CCOCC,,CCN(C(C)C)C(C)C,,val
US04713387,CCOC(=O)/C=C/c1ccc(Cc2cccnc2)cc1>>OC/C=C/c1ccc(Cc2cccnc2)cc1,,CCOCC,,C1CCOC1,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20100137313A1,CCOC(=O)c1cncc(B2OC(C)(C)C(C)(C)O2)c1.Clc1ncc(Br)c(N2CCOCC2)n1>>CCOC(=O)c1cncc(-c2cnc(Cl)nc2N2CCOCC2)c1,,CC#N,O,ClCCl,O=C([O-])[O-].[Na+].[Na+],val
US20090143353A1,CN(C)[C@H]1CCNC1.Cc1c(-c2cccc(F)c2)c(F)c2oc(C(=O)N(C)C)nc2c1C#N>>CN[C@H]1CCN(c2c(-c3cccc(F)c3)c(C)c(C#N)c3nc(C(=O)N(C)C)oc23)C1,,CS(C)=O,,CCN(CC)CC,,val
US20020032168A1,CC(C)NC1CCCC1.N#CCO>>CC(C)N(CC#N)C1CCCC1,,CCO,O,,,val
US20020115853A1,CCC(Br)C(=O)Br.Nc1ccc(Br)cc1S>>CCC1Sc2cc(Br)ccc2NC1=O,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100029609A1,CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1cc(S(=O)(=O)Nc2cccc(-c3ccc(C(=O)N[C@@H](CO)C(=O)O)cc3)c2)c(C)cc1Cl>>C[NH2+]C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1cc(S(=O)(=O)Nc2cccc(-c3ccc(C(=O)N[C@@H](CO)C(=O)[O-])cc3)c2)c(C)cc1Cl,,CO,,,,val
US20020099068A1,O=C1CCC(=O)N1Cl.c1ccc2c(c1)[nH]c1cnccc12>>Clc1ccc2c(c1)[nH]c1cnccc12,,O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090264462A1,COc1c(Br)cc2c(c1Br)CN(C(=O)OC(C)(C)C)[C@@](C)(C(=O)O)C2>>COc1ccc2c(c1)CN(C(=O)OC(C)(C)C)[C@@](C)(C(=O)O)C2,[Pd],CO,,CCN(CC)CC,,val
US20080027112A1,COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OC[C@@H]1OC(=O)[C@H]2OC(C)(C)O[C@@H]12>>COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OC[C@@H]1OC(=O)[C@@H](O)[C@H]1O,,C1CCOC1,,O,O=C(O)C(F)(F)F,val
US20060035921A1,Cc1ccc(S(=O)(=O)Oc2ncc(Br)cc2[N+](=O)[O-])cc1.Nc1ccc(OCc2ccccc2)cc1>>O=[N+]([O-])c1cc(Br)cnc1Nc1ccc(OCc2ccccc2)cc1,,Cc1ccccc1,ClCCl,CCN(CC)CC,,val
US20040220069A1,O=CNCCCc1ccccc1>>C1=NCCCc2ccccc21,,CCCCCC,CCOCC,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20090286782A1,O=[N+]([O-])O.c1ncc2cc[nH]c2n1>>O=[N+]([O-])c1c[nH]c2ncncc12,,O,,O=C([O-])O.[Na+],,val
US20090227541A1,C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.CCOC(C)=O.O>>OCCCOc1cccc2c1B(O)OC2,,O,,Cl,[Li]CCCC,val
US20100331335A1,CCCC[Sn](CCCC)(CCCC)c1cnccn1.N#Cc1csc([N+](=O)[O-])c1Br>>N#Cc1csc([N+](=O)[O-])c1-c1cnccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,,,val
US20080269210A1,CC1(C)OB(c2cnc(N)nc2)OC1(C)C.OCCOCCNc1cccc(-c2cc3nc(Cl)nc(N4CCOCC4)c3s2)c1>>Nc1ncc(-c2nc(N3CCOCC3)c3sc(-c4cccc(NCCOCCO)c4)cc3n2)cn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,,CC(=O)[O-].[K+],,val
US04746671,COC(OC)c1cccc(C(O)c2cccnc2)c1>>COC(OC)c1cccc(C(=O)c2cccnc2)c1,,ClCCl,,,,val
US20090075996A1,CCCCc1ccc(B(O)O)cc1.Nc1cccc(Br)c1>>CCCCc1ccc(-c2cccc(N)c2)cc1,,C1COCCO1,,[Cs+].[F-],,val
US20080227823A1,OCC(Br)C(F)c1ccc(F)c(Br)c1>>OC/C=C(\F)c1ccc(F)c(Br)c1,,CS(C)=O,,CCN(CC)CC,,val
US20050288337A1,CCOC(=O)CCc1ccc(Cn2cccc(-c3ccc(NC(=O)Nc4ccccc4C)cc3)c2=O)cc1>>Cc1ccccc1NC(=O)Nc1ccc(-c2cccn(Cc3ccc(CCC(=O)O)cc3)c2=O)cc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20060235231A1,CCOC(=O)/C=C/c1cccc(Sc2ccc(N(C)C)cc2)c1.NO>>C=C(C(=O)NO)c1cccc(Sc2ccc(N(C)C)cc2)c1,,C1CCOC1,,CO,[K+].[OH-],val
US20080167294A1,CCOC(=O)c1ccc2c(c1)CCC1C2=NN(c2ccc(C#N)c(COC)c2)C1C1CCCC1>>COCc1cc(N2N=C3c4ccc(C(=O)O)cc4CCC3C2C2CCCC2)ccc1C#N,,C1CCOC1,,CO,[Na+].[OH-],val
US05081145,CCC(=O)CC(C)CC(=O)O.COc1ccc(N(N)Cc2ccc(Cl)cc2)cc1>>COc1ccc2c(c1)c(C)c(CC(C)CC(=O)O)n2Cc1ccc(Cl)cc1,,CC(C)O,,Cl,,val
US20110230464A1,C=O.CC(C)(C)OC(=O)N1CC(NC(C)(C)C(N)=O)C1>>CN(C1CN(C(=O)OC(C)(C)C)C1)C(C)(C)C(N)=O,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100029681A1,Nc1nc2ccc(F)cc2s1.O=C(O)CN1CCN(C(c2ccccc2)c2ccccc2)CC1>>O=C(CN1CCN(C(c2ccccc2)c2ccccc2)CC1)Nc1nc2ccc(F)cc2s1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20020095041A1,CN(C)c1ccc(C=O)cc1.c1ccc2sccc2c1>>CN(C)c1ccc(C(O)c2cc3ccccc3s2)cc1,,C1CCOC1,,[Li]C(C)(C)C,,val
US05405851,O=C1CCc2ccc(Br)cc2C1.OCCO>>Brc1ccc2c(c1)CC1(CC2)OCCO1,,CCOCC,c1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050187272A1,CC(C)(C)c1cc(C(=O)O)cc(C(C)(C)C)c1O.O=[N+]([O-])c1ccc(CCO)cc1>>CC(C)(C)c1cc(C(=O)OCCc2ccc([N+](=O)[O-])cc2)cc(C(C)(C)C)c1O,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130345194A1,BrCCCc1ccccc1.CNS(=O)(=O)N1CCN(c2ncnc3c2ccn3C(=O)OC(C)(C)C)CC12CC2>>CN(CCCc1ccccc1)S(=O)(=O)N1CCN(c2ncnc3[nH]ccc23)CC12CC2,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150336949A1,Cc1nn(Cc2cccc(F)c2)c(C)c1-c1c[nH]c2ncc(-c3ccc(C4CCN(C(=O)OC(C)(C)C)CC4)cc3)cc12>>Cc1nn(Cc2cccc(F)c2)c(C)c1-c1c[nH]c2ncc(-c3ccc(C4CCNCC4)cc3)cc12,,ClCCl,O=C(O)C(F)(F)F,,,val
US20060074102A1,N=C(NO)c1cc2c(Nc3ccc(-c4ccccc4)cc3)cncc2s1.O=C(OC(=O)C(Cl)(Cl)Cl)C(Cl)(Cl)Cl>>ClC(Cl)(Cl)c1nc(-c2cc3c(Nc4ccc(-c5ccccc5)cc4)cncc3s2)no1,,Cc1ccccc1,,,,val
US20030166690A1,CCC(CC)N1CCNCC1.COC(=O)c1ccc(OC(=O)Cl)cc1>>CCC(CC)N1CCN(C(=O)Oc2ccc(C(=O)OC)cc2)CC1.Cl,,ClCCl,,,,val
US20060178438A1,CNC(C)=O.Cc1ccc(S(=O)(=O)OCCOC2(C)CC2)cc1>>CC(=O)N(C)CCOC1(C)CC1,,C1CCOC1,,[H-].[Na+],,val
US20040132727A1,COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccc(C)c(SC(C)CO)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)OCCCSc4cc(C)ccc4C)c(C)c3C)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US20090005356A1,CN(C)C(=O)C(O)c1cncc(Br)c1.COc1ccccc1-c1cn(COCC[Si](C)(C)C)c2ncc(B3OC(C)(C)C(C)(C)O3)c(Cl)c12>>COc1ccccc1-c1c[nH]c2ncc(-c3cncc(C(O)C(=O)N(C)C)c3)c(Cl)c12,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20150119385A1,COCCNc1cc(NC(=O)N2CCCc3cc(C4CCOCC4)c(C(OC)OC)nc32)ncc1C#N>>COCCNc1cc(NC(=O)N2CCCc3cc(C4CCOCC4)c(C=O)nc32)ncc1C#N,,C1CCOC1,O,Cl,O=C([O-])O.[Na+],val
US06492416B1,CSc1ccccc1.O=C(Cl)Cc1cccc(F)c1>>CSc1ccc(C(=O)Cc2cccc(F)c2)cc1,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US05494925,CCCC1C(=O)N(CSc2ccccc2)S(=O)(=O)N1CC.O=S(=O)(Cl)Cl>>CCCC1C(=O)N(CCl)S(=O)(=O)N1CC,,ClCCl,,,,val
US20150368273A1,CC(C)(C)[Si](OC[C@H](O)Cn1ccnc1)(c1ccccc1)c1ccccc1.O=C(Cl)OC(Cl)(Cl)Cl>>CC(C)(C)[Si](OC[C@H]1Cn2ccnc2C(=O)O1)(c1ccccc1)c1ccccc1,,CC#N,,c1ccncc1,,val
US04125710,CC(=O)OC[C@H]1O[C@@H](S)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(=O)OC[C@H]1O[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,c1ccncc1,,,,val
US20040157836A1,C#CCCOS(=O)(=O)c1ccc(C)cc1.C1CCOC1.CCNCC>>C#CCCN(CC)CC.C1CCOC1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US04581452,O=C(NCc1ccccc1)NCC(C(=O)O)C(F)(F)F>>O=C1NCC(C(F)(F)F)C(=O)N1Cc1ccccc1,,CN(C)C=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US06306887B1,BrCc1ccccc1.CC(C)(C)OC(=O)NCC(O)CC(=O)O>>CC(O)C(NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130267556A1,CCOC(=O)c1cc2cnccc2n1S(=O)(=O)c1ccc(C)cc1>>COC(=O)c1cc2cccnc2[nH]1,,C1CCOC1,CO,O=C([O-])[O-].[Cs+].[Cs+],,val
US05574042,CC(=O)Nc1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl.CI>>CC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl,,CN(C)C=O,,O,[H-].[Na+],val
US20040198793A1,COC(=O)Cn1c(C(=O)NC(N)=S)cc2cc(C)cc(C)c21.COc1ccc(OC)c(C(=O)C(Br)CC2CCCCC2)c1>>COC(=O)Cn1c(C(=O)Nc2nc(-c3cc(OC)ccc3OC)c(CC3CCCCC3)s2)cc2cc(C)cc(C)c21,,CCO,,CN(C)C=O,,val
US20130158009A1,C1CCNC1.O=C(O)c1ccc(O[C@H]2CCN(C3CCN(c4ncc(C(F)(F)F)cc4Cl)CC3)C2=O)c(F)c1>>O=C(c1ccc(O[C@H]2CCN(C3CCN(c4ncc(C(F)(F)F)cc4Cl)CC3)C2=O)c(F)c1)N1CCCC1,,CCOC(C)=O,CN(C)C=O,,,val
US20140350019A1,CCOC(=O)CBr.Cc1c(O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F>>CCOC(=O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1C,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20050197372A1,CC(C)[C@@H](C(=O)OCc1ccccc1)N(Cc1ccc(-c2ccccc2C#N)cc1)C(=O)CCC1(C)OCCO1>>CC(=O)CCC(=O)N(Cc1ccc(-c2ccccc2C#N)cc1)[C@H](C(=O)OCc1ccccc1)C(C)C,,C1CCOC1,,Cl,,val
US20070293530A1,CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)NN.COC(=N)c1ccccc1>>CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)OCc1ccccc1)c1n[nH]c(-c2ccccc2)n1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20090093483A1,COC(=O)C(C)(C)c1ccc(C(F)(F)F)cc1>>CC(C)(C(=O)O)c1ccc(C(F)(F)F)cc1,,CO,O,[K+].[OH-],,val
US20110183938A1,CCN1CCC(N(C)C(=O)OC(C)(C)C)CC1>>CCN1CCC(NC)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100305096A1,CN(C1CCN(C(=O)OC(C)(C)C)CC1)C1COC1>>CN(C1CCNCC1)C1COC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05710322,C[C@H](N=C(C(=O)NC(C)(C)C)C(C)(C)C)c1ccccc1>>CC(C)(C)NC(=O)[C@@H](N)C(C)(C)C,[Pd],CO,,,,val
US20140296200A1,COc1c(C(=O)O)cnn1-c1ccc(C(=O)NCC2CCOCC2)cn1.O=C1CCC(=O)N1Br>>COc1c(Br)cnn1-c1ccc(C(=O)NCC2CCOCC2)cn1,,CN(C)C=O,O,O=C([O-])O.[Na+],,val
US20100035865A1,CC(C)S(=O)(=O)N[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@H]1c1ccc(-c2ccccc2C#N)cc1.O=C(O)C(F)(F)F>>CC(C)S(=O)(=O)N[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@H]1c1ccc(-c2ccccc2C(N)=O)cc1,,CC#N,O,,,val
US05753664,Cn1cnc2c1c(=O)[nH]c(=O)n2C.O=C(c1ccc(Cl)cc1)c1ccc(CBr)cc1>>Cn1cnc2c1c(=O)n(Cc1ccc(C(=O)c3ccc(Cl)cc3)cc1)c(=O)n2C,,O,,CN(C)C=O,[H-].[Na+],val
US20160046597A1,Cn1cc(C2CCNCC2)c2cc(NC(=O)c3cccc(C#N)c3)ccc21.O=C(O)C1CCCC1>>Cn1cc(C2CCN(C(=O)C3CCCC3)CC2)c2cc(NC(=O)c3cccc(C#N)c3)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20150225379A1,COC(=O)C1(CO)CCN(C(=O)OC(C)(C)C)CC1.Oc1ccccc1F>>COC(=O)C1(COc2ccccc2F)CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04618359,N#Cc1ccc(Oc2ccc(Cl)cc2Cl)cc1C(=O)Cl.OC1CCOC1>>N#Cc1ccc(Oc2ccc(Cl)cc2Cl)cc1C(=O)OC1CCOC1,,Cc1ccccc1,,CCN(CC)CC,,val
US08609731B2,N[C@H]1CCc2cc(CN3CCCC3)ccc2C1.O=C(O)c1ccc(OC[C@@H]2CCCO2)cc1>>O=C(N[C@H]1CCc2cc(CN3CCCC3)ccc2C1)c1ccc(OC[C@@H]2CCCO2)cc1,,CCOC(C)=O,CN1CCCC1=O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05994372,CNC(=O)C(CCCl)(c1ccccc1)c1ccccc1.OC1(c2ccc(Cl)cc2)CCNCC1>>CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1.Cl,,CC(=O)CC(C)C,,,,val
US20110269716A1,CCC1(CC)c2cc(C(=O)O)c(C(=O)O)cc2C(CC)(CC)N1C(=O)c1ccccc1>>CCC1(CC)c2cc(CO)c(CO)cc2C(CC)(CC)N1Cc1ccccc1,,CCOCC,O,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20070213355A1,Nc1cnc2ccc(Br)cc2c1Nc1ccc(F)cc1.O=C(Cl)OC(Cl)(Cl)Cl>>O=c1[nH]c2cnc3ccc(Br)cc3c2n1-c1ccc(F)cc1,,ClCCl,,CCN(CC)CC,,val
US05679696,BrC1CCCC1.COC(=O)c1ccc([N+](=O)[O-])c(O)c1>>COC(=O)c1ccc([N+](=O)[O-])c(OC2CCCC2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160022640A1,Cc1cc(Oc2c([N+](=O)[O-])c(C)nn2-c2ccccc2)n(-c2ccccc2)n1>>Cc1cc(Oc2c(N)c(C)nn2-c2ccccc2)n(-c2ccccc2)n1,,Cl,,O=C([O-])O.[Na+],,val
US20080269220A1,FC(F)(F)c1ccc(Cl)nc1.O=C1CCc2c(O)cccc21>>O=C1CCc2c(Oc3ccc(C(F)(F)F)cn3)cccc21,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070117816A1,CCS(=O)(=O)c1cccc(-c2cn(Cc3ccccc3)c(=O)c3[nH]c4ncc(C)cc4c23)c1>>CCS(=O)(=O)c1cccc(-c2c[nH]c(=O)c3[nH]c4ncc(C)cc4c23)c1,,CC(=O)OC(C)=O,,,,val
US20160039815A1,CC(C)c1ccccc1-c1ncc2c(c1C(O)c1ccc(Cl)cc1)c(=O)n(CCCO[Si](C)(C)C(C)(C)C)c(=O)n2C.O=CO>>CC(C)c1ccccc1-c1ncc2c(c1Cc1ccc(Cl)cc1)c(=O)n(CCCOC=O)c(=O)n2C,[Zn],CCOC(C)=O,O,,,val
US20040229861A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.Nc1cncnc1N>>CC(C)(C)OC(=O)N1CCC(Nc2cncnc2N)CC1,,CC(Cl)Cl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070208020A1,CSc1nc(N)nc(SC)c1C#N.O=C(OO)c1cccc(Cl)c1>>CSc1nc(N)nc(S(C)=O)c1C#N,,ClCCl,,,,val
US20090042890A1,CCOC(=O)c1nc(Nc2cccc(CO[Si](C)(C)C(C)(C)C)c2)nc2c1[nH]c(=O)n2-c1ccccc1OC.COc1ccccc1-n1c(=O)[nH]c2c(C(N)=O)nc(Nc3cccc(CO[Si](C)(C)C(C)(C)C)c3)nc21>>COc1ccccc1-n1c(=O)[nH]c2c(C(N)=O)nc(Nc3cccc(CO)c3)nc21,,CO,N,,,val
US20020183369A1,CCOC(=O)c1cc2sc(C=O)cc2[nH]1>>O=Cc1cc2[nH]c(C(=O)O)cc2s1,,CCOC(C)=O,,O=S(=O)([O-])[O-].[Mg+2],,val
US20080207708A1,CC(C)COc1ccc(Cl)cc1Nc1nc(-c2nc3cc(CO)ccc3[nH]2)cs1>>CC(C)COc1ccc(Cl)cc1Nc1nc(-c2nc3cc(C=O)ccc3[nH]2)cs1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US04066660,COC(=O)c1[nH]c2ccccc2c1Oc1ccccc1N>>Nc1ccccc1Oc1c(C(=O)O)[nH]c2ccccc12,,CCO,,CC(=O)O,O,val
US20100256203A1,CCN(CC)c1cc(NC(=O)c2ccccc2OC)c([N+](=O)[O-])cc1[N+](=O)[O-]>>CCN(CC)c1cc2[nH]c(-c3ccccc3OC)nc2cc1N,[Pd],C1COCCO1,CO,O=C[O-].[NH4+],,val
US05229387,CCNCC.CCOC(=O)c1cc[nH]c1C>>CCN(CC)C(=O)c1cc[nH]c1C,,CCCCCC,Cc1ccccc1,C[Al](C)C,Cl,val
US04868196,CI.Cc1cc(Cl)ccc1OCC(O)(Cn1cncn1)C(C)(C)C>>COC(COc1ccc(Cl)cc1C)(Cn1cncn1)C(C)(C)C,,C1COCCO1,,[H-].[Na+],,val
US04210750,O=C=NC(=O)OCC(Cl)(Cl)Cl.OCc1ccccc1>>NC(=O)OCc1ccccc1,,ClCCl,,,,val
US06277790B1,CCN(C(=O)Cl)C1CCOCC1.O=c1nn[nH]n1-c1ccccc1Cl>>CCN(C(=O)n1nnn(-c2ccccc2Cl)c1=O)C1CCOCC1,CN(C)c1ccncc1,Cc1ccccc1,,,,val
US20070265225A1,CCOC(=O)CBr.O=C1CO[C@H]2Cc3ccccc3[C@H]2N1>>CCOC(=O)CN1C(=O)CO[C@H]2Cc3ccccc3[C@H]21,,CN(C)C=O,,[H-].[Na+],,val
US20080293674A1,COc1cc(OC)nc(CN)n1.O=C(O)c1cnccc1C(F)(F)F>>COc1cc(OC)nc(CNC(=O)c2cnccc2C(F)(F)F)n1,,ClCCl,O=S(Cl)Cl,CCN(CC)CC,CN(C)C=O,val
US20070037808A1,CCCCOC(=O)N(Cc1ccc(OC)cc1)S(=O)(=O)NCC(=O)OCC>>CCOC(=O)CNS(=O)(=O)NCc1ccc(OC)cc1,,CO,,Cl,,val
US20160096827A1,CC(=O)Cl.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@@H]1CCNC1>>CC(=O)N1CC[C@@H](Oc2ccc(-c3ncnc(Nc4ccc(N5CCN(C6COC6)CC5)cc4)n3)cc2C#N)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06162832,CCOc1ccc(Oc2ccc(O)cc2)c(N)c1.Fc1ccc(F)c(CBr)c1>>CCOc1ccc(Oc2ccc(OCc3cc(F)ccc3F)cc2)c(N)c1,,CN(C)C=O,,O,CC(C)(C)[O-].[K+],val
US05430027,NOCc1ccccc1.O=C(OC[C@H]1O[C@@H](n2cnc3c(Cl)nc(Cl)nc32)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1)c1ccccc1>>O=C(OC[C@H]1O[C@@H](n2cnc3c(NOCc4ccccc4)nc(Cl)nc32)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1)c1ccccc1,,C1COCCO1,,CCN(C(C)C)C(C)C,Cl,val
US20050227995A1,O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.O=S(=O)(c1ccc(Cl)cc1)C(CCO)c1cc(F)ccc1F.OC1CCNCC1>>O=C(OCCC(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)N1CCC(O)CC1,,C1CCOC1,CC#N,c1ccncc1,,val
US04992433,CCOC(=O)N1CCC(CCC(=O)O)CC1.O=S(Cl)Cl>>CCOC(=O)N1CCC(CCC(=O)Cl)CC1,,ClC(Cl)Cl,,,,val
US20130131016A1,C=C(c1cc(F)c(F)c(F)c1)C(F)(F)F.CC1(C)OB(O)c2ccc(C(Cl)=NO)cc21>>CC1(C)OB(O)c2ccc(C3=NOC(c4cc(F)c(F)c(F)c4)(C(F)(F)F)C3)cc21,,CN(C)C=O,,,,val
US20060281746A1,CNCc1ccccc1.O=C1OC[C@@H]2C[C@]12c1ccccc1>>CN(Cc1ccccc1)C(=O)[C@@]1(c2ccccc2)C[C@H]1CO,,C1CCOC1,ClCCl,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20110183960A1,BrCCCOC1CCCCO1.COC(=O)c1cc(-c2ccc(O)cc2)c(-c2ccccc2Cl)s1>>COC(=O)c1cc(-c2ccc(OCCCOC3CCCCO3)cc2)c(-c2ccccc2Cl)s1,,CCOCC,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05672710,CCOC(=O)c1cnc(Sc2cc3c(cc2C)C(C)(C)CCC3(C)C)s1>>Cc1cc2c(cc1Sc1ncc(C(=O)O)s1)C(C)(C)CCC2(C)C,,C1CCOC1,,CO,[Li+].[OH-],val
US20070232645A1,CC(C)S(=O)(=O)Cl.Cc1ccc2c(Nc3cc(Cl)ccc3Oc3ccc(O)cc3)ccnc2n1>>Cc1ccc2c(Nc3cc(Cl)ccc3Oc3ccc(OS(=O)(=O)C(C)C)cc3)ccnc2n1,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040023974A1,COC(=O)C(Cc1ccc([N+](=O)[O-])c(OCc2ccccc2)c1)(NC(=O)OC(C)(C)C)C(=O)OC>>COC(=O)C(Cc1ccc([N+](=O)[O-])c(OCc2ccccc2)c1)NC(=O)OC(C)(C)C,,CS(C)=O,O,,,val
US20140194431A1,COc1ccc(Br)c(CC#N)c1.[Cl-].[NH4+]>>COc1ccc(Br)c(CC(=N)N)c1.Cl,,Cc1ccccc1,,C[Al](C)C,,val
US04249937,C=CCON.CCCC(=O)C1C(=O)CC(CC(C)S(=O)CC)CC1=O>>C=CCONC(CCC)=C1C(=O)CC(CC(C)S(=O)CC)CC1=O,,CCO,,,,val
US04474777,C[C@H](NC(=O)OCc1ccccc1)C(=O)O.Nc1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1Cl>>C[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1Cl,,C1CCOC1,,O=S(Cl)Cl,,val
US20090325993A1,O=C(CBr)Nc1cccc(C(F)(F)F)c1.O=C1NC2(CCOC2)N=C1c1ccc(Br)cc1>>O=C(CN1C(=O)C(c2ccc(Br)cc2)=NC12CCOC2)Nc1cccc(C(F)(F)F)c1,,CN(C)C=O,,[H-].[Na+],,val
US20090131402A1,CC(C)(C)[Si](C)(C)OCCN(Cc1ccccc1)C(=O)c1cccnc1Cl>>OCCN(Cc1ccccc1)Cc1cccnc1Cl,,C1CCOC1,,CO,,val
US20150175594A1,CC(=O)Nc1sc2c(c1-c1nc(C)no1)CCCC2>>Cc1noc(-c2c(N)sc3c2CCCC3)n1,,CCO,CO,C[O-].[Na+],,val
US20060142265A1,O=C(O)COc1ccccc1C(=O)O.O=P(Cl)(Cl)Cl>>O=Cc1oc2ccccc2c1Cl,,CN(C)C=O,,,,val
US20040248923A1,COC(=O)CCCCl.COc1cc2c(Nc3ccccc3C)c(C(N)=O)cnc2cc1O>>COC(=O)CCCOc1cc2ncc(C(N)=O)c(Nc3ccccc3C)c2cc1OC,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05324832,CI.O=C1Nc2cccnc2Nc2ccc(S(=O)(=O)Cl)cc21>>CSc1ccc2c(c1)C(=O)Nc1cccnc1N2,,C1COCCO1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090203677A1,CC(C)(C)OC(=O)N1CCC(Cc2cccc(-c3cccc(CN)c3)c2)CC1.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)CC(=O)O>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)CC(=O)NCc1cccc(-c2cccc(CC3CCNCC3)c2)c1,,ClCCl,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US03965174,CC(=O)OC(C)=O.CCN(N)CC>>CCN(CC)NC(C)=O,,ClC(Cl)(Cl)Cl,,c1ccccc1,,val
US05597823,COC(=O)CS.N#Cc1cccc(C#N)c1Cl>>COC(=O)c1sc2c(C#N)cccc2c1N,,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US20090124604A1,CCOC(C)=O.Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(O[C@H]3CCNC3)cc2c1=O>>Cc1ccc(C(=O)O)cc1-n1cnc2ccc(O[C@H]3CCNC3)cc2c1=O,,Br,,,,val
US05599813,CC1=C(C(=O)OC(C)(C)C)SC2=NCC(C)(C)CN21.Cl>>CC1=C(C(=O)O)SC2=NCC(C)(C)CN21.Cl,,Cl,,,,val
US20130115190A1,C=CCCC(C)O.CS(=O)(=O)Cl>>C=CCCC(C)OS(C)(=O)=O,,ClCCl,ClCCl,CCN(CC)CC,,val
US20060287522A1,Cc1cccc(C)c1-c1ccc(C(=O)Cl)cc1.O=C(NCc1cccnc1)c1ccc2n1Cc1ccccc1NC2>>Cc1cccc(C)c1-c1ccc(C(=O)N2Cc3ccc(C(=O)NCc4cccnc4)n3Cc3ccccc32)cc1,,C1CCOC1,ClCCl,CCN(C(C)C)C(C)C,,val
US06489321B1,CN(C)CCC1C=CN(C(=O)c2ccc(N)cc2)c2ccccc2S1.O=C(Cl)c1ccccc1-c1ccccc1>>CN(C)CCC1C=CN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1,,ClCCl,,CCN(CC)CC,O,val
US05652271,BrBr.CC(=O)C1(c2cccc(Cl)c2)CCC1>>O=C(CBr)C1(c2cccc(Cl)c2)CCC1,,CO,ClCCl,,,val
US05877199,CSc1c(CC(=O)OC(C)(C)C)ccc2c1[nH]c1ccccc12>>CSc1c(CC(=O)O)ccc2c1[nH]c1ccccc12,,O=CO,,,,val
US05340811,COc1ccc(CCN)cc1OC.Cc1ccc(S(=O)(=O)OC(C)CNS(=O)(=O)c2ccc(Cl)c3ncccc23)cc1>>COc1ccc(CCNC(C)CNS(=O)(=O)c2ccc(Cl)c3ncccc23)cc1OC,,C1CCOC1,,,,val
US20090149447A1,C[C@H]1CN(Cc2cccc(-c3ccc(F)c(CN)c3)c2)CCN1C(=O)OC(C)(C)C.O=C(O)c1cccc(C2CCNCC2)c1>>C[C@H]1CN(Cc2cccc(-c3ccc(F)c(CNC(=O)c4cccc(C5CCNCC5)c4)c3)c2)CCN1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070066618A1,Cc1ccc(S(=O)(=O)NC(=O)OCCc2ccc(Nc3cc(Cl)c(C(F)(F)F)cc3[N+](=O)[O-])cc2)cc1>>Cc1ccc(S(=O)(=O)NC(=O)OCCc2ccc(Nc3cc(Cl)c(C(F)(F)F)cc3N)cc2)cc1,,CO,,,,val
US20160251339A1,COc1ccc(S(=O)(=O)Cl)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1.Fc1ccc2cc[nH]c2c1>>COc1ccc(S(=O)(=O)n2ccc3ccc(F)cc32)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1,,C1CCOC1,,[H-].[Na+],,val
US20070105904A1,Cc1ccnc(C)c1.O=C(OO)c1cccc(Cl)c1>>Cc1cc[n+]([O-])c(C)c1,,ClCCl,,O=S([O-])O.[Na+],,val
US20100137299A1,COc1cc2c(cc1C)C1(CO2)C(=O)Nc2ccccc21>>COc1cc2c(cc1C)[C@]1(CO2)C(=O)Nc2ccccc21,,COC(C)(C)C,,CC#N,,val
US20090186879A1,[N-]=[N+]=NC(c1ccc(Cl)c2nc3n(c12)CCCN3c1c(Cl)cc(Cl)cc1Cl)C(F)(F)F>>NC(c1ccc(Cl)c2nc3n(c12)CCCN3c1c(Cl)cc(Cl)cc1Cl)C(F)(F)F,,C1CCOC1,CCOC(C)=O,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080132540A1,CC(C)(C)OC(=O)N1CCc2ccc(N(C(=O)/C=C/c3ccccc3)C3CCN(Cc4ccccc4)CC3)cc21.O=C(O)C(F)(F)F>>O=C(/C=C/c1ccccc1)N(c1ccc2c(c1)NCC2)C1CCN(Cc2ccccc2)CC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04249015,COC(=O)C1C=CCCCCCCCCC1>>COC(=O)C1=CCCCCCCCCCC1,,CO,Cl,[Na],,val
US05455250,CC(C(=O)c1ccc(O)cc1)N1CCC(O)(c2ccccc2)CC1.O=C(O)c1ccc(CN2CCOCC2)cc1>>CC(C(=O)c1ccc(OC(=O)c2ccc(CN3CCOCC3)cc2)cc1)N1CCC(O)(c2ccccc2)CC1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20110269705A1,CCCOc1cc2c(c3c(=O)c(-c4ccc(OC)cc4)cn(CC(=O)OCC)c13)OCCC2>>CCCOc1cc2c(c3c(=O)c(-c4ccc(OC)cc4)cn(CC(=O)O)c13)OCCC2,,CCO,,[Na+].[OH-],,val
US20100130468A1,CCOC(=O)c1cc(Br)cc2c(CC3CCCS(=O)(=O)C3)c[nH]c12>>O=C(O)c1cc(Br)cc2c(CC3CCCS(=O)(=O)C3)c[nH]c12,,CO,,[Li+].[OH-],,val
US20160039821A1,C=O.Cn1cc(-c2cc(CS(C)(=O)=O)ccc2NCC(C)(C)CN2CCOCC2)c2cc[nH]c2c1=O>>Cn1cc2c3c(c[nH]c3c1=O)CN(CC(C)(C)CN1CCOCC1)c1ccc(CS(C)(=O)=O)cc1-2,Cl[Ti](Cl)(Cl)Cl,C1CCOC1,,CCOC(C)=O,O=C([O-])O.[Na+],val
US20040209879A1,CC(=O)Nc1ccccc1O.O=C(CCCN1CCCC(COS(=O)(=O)c2ccccc2)C1)c1ccc(F)cc1>>CC(=O)Nc1ccccc1OCC1CCCN(CCCC(=O)c2ccc(F)cc2)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060178360A1,CN1CCNCC1.O=C(O)Cc1ccncc1>>CN1CCN(C(=O)Cc2ccncc2)CC1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20140179667A1,Cc1cc(CO[Si](C)(C)C(C)(C)C)c(CO)c(OCc2ccccc2)n1.O=C1CCC(=O)N1Cl>>Cc1cc(CO[Si](C)(C)C(C)(C)C)c(CCl)c(OCc2ccccc2)n1,,ClCCl,,CSC,,val
US20010034343A1,CCOCCn1c(N2CCCN(CCC3(c4ccccc4)CCNC3)CC2)nc2ccccc21.COc1ccc(-c2nnn[nH]2)cc1C(=O)O>>CCOCCn1c(N2CCCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(-c5nnn[nH]5)ccc4OC)C3)CC2)nc2ccccc21,,CO,ClCCl,Cl,,val
US20110257165A1,BrCBr.COc1cccc(C(=O)Cc2ccncc2)c1.S=C=S>>COc1cccc(C(=O)C(=C2SCS2)c2ccncc2)c1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20050026836A1,CC(C)(C)OC(=O)[C@H]1CCCCN1S(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1.Cl>>Cl.N=C(N)Nc1ncc(Cl)c2ccc(S(=O)(=O)N3CCCC[C@@H]3C(=O)O)cc12,,CCOC(C)=O,,,,val
US20140094459A1,N#CCC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4cccc(F)c4F)cc3)c3c(N)ncnc32)C1.O=CC1CC1>>N#CC(=CC1CC1)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4cccc(F)c4F)cc3)c3c(N)ncnc32)C1,,CO,,C1CCNCC1,,val
US20070197512A1,COC(=O)CN1C(=O)COc2ccccc21>>O=C(O)CN1C(=O)COc2ccccc21,,CO,,[Na+].[OH-],,val
US20020115861A1,CC(C)(O)C(=O)O.CC(C)CNc1c(N)cnc2ccccc12>>CC(C)Cn1c(C(C)(C)O)nc2cnc3ccccc3c21,,O,,,,val
US20130090323A1,COC[C@H]1CCCN1.Cc1c(Cl)nc2cc(F)cc(F)c2c1Cl>>COC[C@H]1CCCN1c1nc2cc(F)cc(F)c2c(Cl)c1C,,CC#N,,CCN(CC)CC,,val
US04990518,ClP(Cl)(Cl)(Cl)Cl.O=C(c1ccc(CO)nc1)N(C1CCCC1)C1CCCC1>>O=C(c1ccc(CCl)nc1)N(C1CCCC1)C1CCCC1,,ClC(Cl)Cl,O,O=C([O-])[O-].[K+].[K+],,val
US20140371261A1,COC(=O)CBr.COc1ccc([N+](=O)[O-])c(CC#N)n1>>COC(=O)CC(C#N)c1nc(OC)ccc1[N+](=O)[O-],,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20070244159A1,COC(=O)C1(c2ccc([N+](=O)[O-])cc2)CC1>>COC(=O)C1(c2ccc(N)cc2)CC1,[Ni],CO,,,,val
US20140031349A1,CC(C)(C)OC(=O)N1CCC2(CC1)CCN(C1=C(C=O)C(=O)OC1)C2=O>>CC(C)(C)OC(=O)N1CCC2(CC1)CCN(C1=C(CO)C(=O)OC1)C2=O,,C1CCOC1,,CO,[BH4-].[Na+],val
US20150158826A1,CC(C)(C)C(=O)Nc1cccc(C(=O)c2ccc3ncc(N4CCOCC4)nc3c2)c1>>Nc1cccc(C(=O)c2ccc3ncc(N4CCOCC4)nc3c2)c1,,CC(=O)O,,Cl,[Na+].[OH-],val
US20130274260A1,O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1cccc(CCl)c1.OB(O)c1ccccc1F>>O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1cccc(Cc2ccccc2F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,[I-].[Na+],,val
US20100016396A1,Cc1nn(C)c(Oc2cc(O[C@@H](C)C(=O)O)c(Cl)cc2Cl)c1C(=O)NNC(=O)OC(C)(C)C.Cl>>Cc1nn(C)c(Oc2cc(O[C@@H](C)C(=O)O)c(Cl)cc2Cl)c1C(=O)NN.Cl,,CCOC(C)=O,,,,val
US20100249124A1,CI.O=c1[nH]c2cc([N+](=O)[O-])ccc2o1>>Cn1c(=O)oc2ccc([N+](=O)[O-])cc21,,CN(C)C=O,,[H-].[Na+],,val
US04721721,NC(N)=S.O=C1CCc2cc(C(=O)CCl)ccc2N1>>Nc1nc(-c2ccc3c(c2)CCC(=O)N3)cs1,,CCO,,,,val
US20120115811A1,CC#N.COC(=O)c1ccnc(OC)c1>>COc1cc(C(=O)CC#N)ccn1,,C1CCOC1,,[Li]CCCC,,val
US20150023916A1,COc1ccc(N)cc1.O=[N+]([O-])c1cc(O)ccc1F>>COc1ccc(Nc2ccc(O)cc2[N+](=O)[O-])cc1,,CCOC(C)=O,CN1CCCC1=O,CCN(C(C)C)C(C)C,,val
US20060173018A1,Cc1ccc2c(N3CCC[C@@H](CNC(=O)O[C@H]4CCOC4)C3)nc(-c3ccccc3O)nc2c1.Cl>>Cc1ccc2c(N3CCC[C@H](CN(C(=O)O)[C@H]4CCOC4)C3)nc(-c3ccccc3O)nc2c1.Cl,,ClCCl,,CCOCC,,val
US20150361100A1,COC(=O)c1c(C(=O)OC)c2cccnn2c1C(=O)OC(C)(C)C>>O=C(O)c1cc2cccnn2c1,,O,,Cl,[K+].[OH-],val
US06380230B1,CC(OS(=O)(=O)C(F)(F)F)C1CCCCC1.COc1cc(C)cc(OC)c1-c1csc(-n2c(C)ccc2C)n1>>COc1cc(C)cc(OC)c1-c1nc(-n2c(C)ccc2C)sc1CCC1CCCCC1,,CCCCCC,,O,[Li]CCCC,val
US04749790,CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1.O=C(O)/C=C/c1ccc(O)c(O)c1>>CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1.O=C([O-])/C=C/c1ccc(O)c(O)c1,,ClCCl,,,,val
US20140110686A1,Brc1ccc(-c2ccc3ccccc3c2)cc1.CC(C)OB(OC(C)C)OC(C)C>>OB(O)c1ccccc1,,CCCCCC,O,C1CCOC1,[Li]CCCC,val
US20060223849A1,CC(C)(C)OC(=O)N1CCc2nc(NC(=O)c3cccc4nc(NC(=O)c5cc6ccccc6cn5)[nH]c34)sc2C1>>O=C(Nc1nc2cccc(C(=O)Nc3nc4c(s3)CNCC4)c2[nH]1)c1cc2ccccc2cn1,,CO,,Cl,,val
US20010039285A1,Cc1ccc(S(=O)(=O)Oc2ccc(C3c4ccc(OCCN5CCCC5)cc4CCN3C(=O)C(F)(F)F)cc2)cc1>>O=C(N1CCc2cc(OCCN3CCCC3)ccc2C1c1ccc(O)cc1)C(F)(F)F,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100021423A1,COc1c(/C=C/c2ccc(NS(C)(=O)=O)cc2)cc(-c2cc(F)cn(COC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)c2=O)cc1C(C)(C)C>>COc1c(/C=C/c2ccc(NS(C)(=O)=O)cc2)cc(-c2cc(F)cn(COC(=O)[C@@H](N)C(C)C)c2=O)cc1C(C)(C)C,,ClCCl,,C1COCCO1,Cl,val
US20120094987A1,C1CNCCN1.COc1ccc(-c2cc(C)c3c(n2)sc2c(Cl)nc(Cl)nc23)cc1OC>>COc1ccc(-c2cc(C)c3c(n2)sc2c(N4CCNCC4)nc(Cl)nc23)cc1OC,,C1CCOC1,,CCN(CC)CC,,val
US20080051418A1,COC(=O)CCc1ccc(O)cc1OC(C)C.FC(F)(F)c1ccc(Cl)nc1>>COC(=O)CCc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1OC(C)C,,C1CCOC1,,O,[H-].[Na+],val
US20100267666A1,CC(C)(C)C(=O)c1c[nH]c2ncc(Br)nc12.CC(C)Oc1cccc(B(O)O)c1>>CC(C)Oc1cccc(-c2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)c1,,CCOC(C)=O,,,,val
US20120128588A1,CCCCO.O=C(O)Cc1ccc(-c2ccccc2)c(F)c1>>CCCCOC(=O)Cc1ccc(-c2ccccc2)c(F)c1,,CCCCO,,,,val
US20090099190A1,CCNc1cc(N(C)OC)ncc1CCl.Nc1ccc(F)c([N+](=O)[O-])c1>>CCNc1cc(N(C)OC)ncc1CNc1ccc(F)c([N+](=O)[O-])c1,,c1ccncc1,,,,val
US20150291573A1,CI.O=S(=O)(c1cccc(OC(F)F)c1)C1CCOC(c2ccc(Br)cc2F)C1>>CC1(S(=O)(=O)c2cccc(OC(F)F)c2)CCOC(c2ccc(Br)cc2F)C1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US05075435,CCOC(=O)C(C)[C@@H]1[C@@H]([C@@H](C)O[Si](C)(C)C(C)(C)C)C(=O)N1[Si](C)(C)C(C)(C)C>>CCOC(=O)C(C)[C@H]1NC(=O)[C@@H]1[C@@H](C)O[Si](C)(C)C(C)(C)C,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US08569503B2,COCCN(Cc1ccc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)nc1)C(=O)OC(C)(C)C.O=C(O)C1(C(=O)Nc2ccc(F)cc2)CC1>>COCCN(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)cc4F)c3s2)nc1)C(=O)OC(C)(C)C,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05744471,COc1ccc(NN2C(=O)c3[nH]c4cc(Cl)ccc4c(=O)c3C2=O)cc1>>COc1ccc(-n2nc(O)c3c(=O)c4ccc(Cl)cc4[nH]c3c2=O)cc1,,CO,,CS(=O)(=O)O,,val
US20130085132A1,C[C@@H](OCc1cc(F)cc(-c2cc(N)nn2-c2ccc(F)cc2)c1)C(F)(F)F.O=C1NC[C@H](C(=O)O)N1>>C[C@@H](OCc1cc(F)cc(-c2cc(NC(=O)[C@H]3CNC(=O)N3)nn2-c2ccc(F)cc2)c1)C(F)(F)F,,ClC(Cl)Cl,,CCN=C=NCCCN(C)C,Cl,val
US20130296344A1,CI.COc1cc(C2C(C#N)=C(N)Oc3c2ccc2c(N)cccc32)cc(Br)c1OC>>CNc1cccc2c3c(ccc12)C(c1cc(Br)c(OC)c(OC)c1)C(C#N)=C(N)O3,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20040186103A1,C[C@H](C(=O)O)c1ccc(F)cc1.Cc1ccc(NC(=O)C(C)C)cc1C1CCN(CCCN)CC1>>Cc1ccc(NC(=O)C(C)C)cc1C1CCN(CCCNC(=O)[C@@H](C)c2ccc(F)cc2)CC1,,CO,,,,val
US20160128984A1,COC(=O)CCNC(=O)c1cc(-c2ccccc2)no1>>O=C(O)CCNC(=O)c1cc(-c2ccccc2)no1,,C1CCOC1,O,[Li+].[OH-],,val
US04647566,O=C(OCc1ccccc1)OC1CCc2[nH]cc3c(=O)n(-c4ccc(Cl)cc4)nc-3c2C1>>O=c1c2c[nH]c3c(c-2nn1-c1ccc(Cl)cc1)CC(O)CC3,[Pd],CCO,CN(C)C=O,[H][H],,val
US05252741,N#Cc1cccnc1.Nc1ccc(F)cc1F>>Fc1ccc(NCc2cccnc2)c(F)c1,[Rh],,,[H][H],,val
US20150038488A1,COc1ccc([C@@H](C)N2C[C@H]([C@@H](C)O)CC2=O)cc1.Cc1nc2cc(Cl)nc(Cl)c2n1C>>COc1ccc([C@@H](C)N2C[C@H]([C@@H](C)Oc3nc(Cl)cc4nc(C)n(C)c34)CC2=O)cc1,,C1CCOC1,,CC(C)(C)O[K],,val
US20080234199A1,CCCCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(OCC(=O)OCC)cc1>>CCCCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(OCCO)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040053974A1,CCOC(=O)C(Cc1ccc(OCc2ccccc2)cc1)OS(C)(=O)=O.Oc1ccc(Cl)cc1>>CCOC(=O)C(Cc1ccc(OCc2ccccc2)cc1)Oc1ccc(Cl)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05849911,CC[C@H](C)[C@H](NC(=O)OC)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(N)Cc1ccc(-c2cncs2)cc1.CC[C@H](C)[C@H](NC(=O)OC)C(=O)O>>CC[C@H](C)[C@H](NC(=O)OC)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2cncs2)cc1)NC(=O)[C@@H](NC(=O)OC)[C@@H](C)CC,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20100168418A1,COc1ccc2ncc(=O)n(CCN3CCC(N(Cc4nc5c(cc4Cl)SCC(=O)N5C)C(=O)OC(C)(C)C)CC3)c2c1>>COc1ccc2ncc(=O)n(CCN3CCC(NCc4nc5c(cc4Cl)SCC(=O)N5C)CC3)c2c1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20100029611A1,C[C@H](NCc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1)C(=O)OC(C)(C)C>>C[C@H](NCc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070032478A1,Cc1cc(C(=O)Cl)n(C)n1.Nc1ccc(C(=O)c2ccc3c(c2)NC(=O)C3)cc1>>Cc1cc(C(=O)Nc2ccc(C(=O)c3ccc4c(c3)NC(=O)C4)cc2)n(C)n1,,C1CCOC1,,,,val
US04476308,CC(=O)Cl.NC(=O)CN1CCC(O)C1=O>>CC(=O)OC1CCN(CC(N)=O)C1=O,,ClC(Cl)Cl,,,,val
US04645765,CI.COC(OC)c1cc(OC(C)=O)c2c(c1)N1CC3NC3C(OC(C)=O)(O1)C2COC(N)=O>>COC(OC)c1cc(OC(C)=O)c2c(c1)N1CC3C(N3C)C(OC(C)=O)(O1)C2COC(N)=O,,C1CCOC1,,CC(=O)O,[H-].[Na+],val
US20100197683A1,CCCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2ncnn12.O=C([O-])O.[NH3+]O>>CCCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2ncnn12,,CCOC(C)=O,,CS(C)=O,[Cl-].[Na+],val
US20110166132A1,CO.Cn1ccnc1C(=O)C(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COC(=O)c1nc(Br)cn1C,,CO,,C1CCOC1,[H-].[Na+],val
US05206256,N#Cc1ccc2c(c1)CCC=C2n1ccnc1.OO>>NC(=O)c1ccc2c(c1)CCC=C2n1ccnc1,,CS(C)=O,ClCCl,O,O=C([O-])[O-].[K+].[K+],val
US20160052888A1,CC(=O)O[C@@H]1CCc2cc([C@H]3CC[C@]4(COC(=O)N4)C3)ccc2C1>>O=C1N[C@@]2(CC[C@H](c3ccc4c(c3)CC[C@@H](O)C4)C2)CO1,,CCOC(C)=O,CO,[Na+].[OH-],,val
US05679683,CC(C)=O.ClCCl.Clc1ncnc2[nH]c3ccccc3c12.c1ccc2c(c1)[nH]c1ncncc12>>CCN(CC)CCn1c2ccccc2c2c(Cl)ncnc21,,ClCCl,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20120245187A1,CC1c2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cccc(C(F)(F)F)c3)c2)CN1C(=O)OC(C)(C)C>>O=C(Nc1cccc(C(F)(F)F)c1)n1ccc2ccccc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070049593A1,COC(=O)c1ccc2c(C3CCCCC3)c(-c3cccc([N+](=O)[O-])c3OCCO)[nH]c2c1.CS(=O)(=O)Cl>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3cccc([N+](=O)[O-])c3OCCOS(C)(=O)=O)[nH]c2c1,,ClC(Cl)Cl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US04116674,C=CCN.CCCc1c(C)nc(SC)[nH]c1=O>>C=CCNc1nc(C)c(CCC)c(=O)[nH]1,,O,,CC(=O)O,,val
US04118483,NC(=O)CC[C@@H](NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1.NCc1ccccc1>>O=C(CC[C@@H](NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1)NCc1ccccc1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20070043090A1,BrBr.CCCC1(C(CC=CCO)O[Si](C)(C)C(C)(C)C)CCC1>>CCCC1(C(CC=CCBr)O[Si](C)(C)C(C)(C)C)CCC1,,CCCCCC,ClCCl,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040077712A1,CC(C)(CO)C(O)c1ccc2ccccc2c1.O=P(Cl)(Cl)Cl>>CC1(C)COP(=O)(Cl)OC1c1ccc2ccccc2c1,,ClCCl,,CCN(CC)CC,O,val
US06204293B1,CCCCOC[C@@H](O)CC1CCCCC1.COC(=O)c1ccc(CI)cc1-c1ccccc1C>>CCCCOCC(CC1CCCCC1)OCc1ccc(C(=O)OC)c(-c2ccccc2C)c1,,CN(C)C=O,,O,[H-].[Na+],val
US20090131461A1,CC(=O)OC(C)=O.COc1cc([N+](=O)[O-])ccc1O>>COc1cc([N+](=O)[O-])ccc1OC(C)=O,,ClCCl,,c1ccncc1,,val
US20140081024A1,CCOC(=O)N=C=S.COc1ncc(OC)c(N)n1.NO>>COc1cnc(OC)n2nc(N)nc12,,Cc1ccccc1,,O,,val
US04748161,CCC(=O)Oc1ccc(C=C(C)C(=O)O)cc1OC>>COc1cc(C=C(C)C(=O)O)ccc1O,,C1COCCO1,,N,,val
US04942245,CCCc1c(OCCBr)ccc(C(C)=O)c1O.CCOC(=O)c1ccc2nc(S)[nH]c2c1>>CCCc1c(OCCSc2nc3ccc(C(=O)OCC)cc3[nH]2)ccc(C(C)=O)c1O,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20140256734A1,CC(C)(C)OC(=O)N1CCC[C@H]1CNc1nc(C#N)cc2ccccc12.CCOC(=O)NN>>CC(C)(C)OC(=O)N1CCC[C@H]1CNc1nc(-c2n[nH]c(=O)[nH]2)cc2ccccc12,,CCOC(C)=O,,,,val
US05114945,CC(O)O.Cl.O=C1CCC(CN2CCCC2)N(C(=O)Cc2ccc(Cl)c(Cl)c2)C1>>Cl.O=C(Cc1ccc(Cl)c(Cl)c1)N1CC2(CCC1CN1CCCC1)OCCO2,,Cc1ccccc1,ClCCl,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150023990A1,CC(C)N=C=O.CCOCc1nc2c(N)nc3cc(OCCCCCCN)ccc3c2n1CC(C)(C)N(C(N)=O)C(C)C>>CCOCc1nc2c(N)nc3cc(OCCCCCCNC(=O)NC(C)C)ccc3c2n1CC(C)(C)N(C(N)=O)C(C)C,,ClCCl,,,,val
US20050221988A1,COCCN.CSCc1c(C(=O)O)ccc(S(C)(=O)=O)c1F>>COCCNc1c(S(C)(=O)=O)ccc(C(=O)O)c1CSC,,O,,Cl,,val
US20040204450A1,CCO.CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1CC>>CCOC(=O)C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CC(CC)N(C(=O)OCC)c2ccc(C(F)(F)F)cc21,O=S(=O)(O)O,,,,,val
US20040006143A1,CC(C)(C)OC(=O)N(CCc1ccc(O)cc1)C[C@H](O)c1cccc(Cl)c1.COC(=O)c1cnc(Cl)c(Cl)c1>>COC(=O)c1cnc(Oc2ccc(CCN(C[C@H](O)c3cccc(Cl)c3)C(=O)OC(C)(C)C)cc2)c(Cl)c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130237571A1,CCN(CC)CC.CO/N=C(\COc1ccc(COc2ccc(C3OC(=O)OC3C(=O)OC)cc2)cc1)c1ccccc1.Sc1ccccc1>>CCOC(=O)C(Sc1ccccc1)C(O)c1ccc(OCc2ccc(OC/C(=N\OC)c3ccccc3)cc2)cc1,,C1CCOC1,,,,val
US20080255115A1,C=C[Sn](CCCC)(CCCC)CCCC.Clc1ccnc2ccc(Br)cc12>>C=Cc1ccc2nccc(Cl)c2c1,,C1COCCO1,,,,val
US20100204196A1,COc1cc2c(cc1[N+](=O)[O-])N(C(=O)CN(C)C)[C@@H](C)C2>>COc1cc2c(cc1N)N(C(=O)CN(C)C)[C@@H](C)C2,[Pd],CO,,,,val
US20100273744A1,BrCc1ccccc1.OCc1ccc(O)cc1C(F)(F)F>>OCc1ccc(OCc2ccccc2)cc1C(F)(F)F,,CCO,ClCCl,[Na+].[OH-],,val
US20070249670A1,COC(=O)[C@@H](NC(=O)c1ccc(F)cc1[N+](=O)[O-])C1CCCC1>>COC(=O)[C@@H](NC(=O)c1ccc(F)cc1N)C1CCCC1,[Pd],CCO,,,,val
US07446127B2,CC(C)(C)OC(=O)C1COc2cc(O)ccc2C1.Cc1oc(-c2ccccc2)nc1CCOS(C)(=O)=O>>Cc1oc(-c2ccccc2)nc1CCOc1ccc2c(c1)OCC(C(=O)OC(C)(C)C)C2,,CC#N,CCOCC,O=C([O-])[O-].[K+].[K+],,val
US20110201605A1,CC(C)(O)c1cc(-c2ccc(C(F)(F)F)cc2)nc(Cl)n1.Cc1nnc(N2CCC(N)CC2)o1>>Cc1nnc(N2CCC(Nc3nc(-c4ccc(C(F)(F)F)cc4)cc(C(C)(C)O)n3)CC2)o1,,C1COCCO1,O,CCN(C(C)C)C(C)C,,val
US20110275611A1,CC[C@@H]1CO[C@H](C(=O)O)CN1C(=O)OC(C)(C)C.Nc1ccccc1>>CC[C@@H]1CO[C@H](C(=O)Nc2ccccc2)CN1C(=O)OC(C)(C)C,,ClCCl,,ClCCCl,On1nnc2cccnc21,val
US20110105436A1,Cc1cccc(Nc2nc(-c3ccnc([N+](=O)[O-])c3)cs2)c1>>Cc1cccc(Nc2nc(-c3ccnc(N)c3)cs2)c1,[Pd],CCO,,,,val
US20080045521A1,COC(=O)[C@H](Cc1ccc(CCCc2ccc3c(n2)NCCO3)cc1)NC(=O)OC(C)(C)C>>COC(=O)[C@@H](N)Cc1ccc(CCCc2ccc3c(n2)NCCO3)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080188521A1,C=CCc1ccc2c(-c3ccccc3)cc(C#N)nc2c1.O=[O+][O-]>>N#Cc1cc(-c2ccccc2)c2ccc(CC=O)cc2n1,,CCOC(C)=O,,CSC,,val
US06274623B1,CC(=O)Oc1ccc(CBr)cc1OC(C)=O.CN1[C@H]2CC[C@@H]1CC(OC(=O)CCC(=O)OC1C[C@@H]3CC[C@H](C1)N3C)C2.COc1ccc(OC)c(CBr)c1>>CC(=O)Oc1ccc(C[N+]2(C)[C@H]3CC[C@@H]2CC(OC(=O)CCC(=O)[O-])C3)cc1OC(C)=O.[Br-].[Br-],,CC(C)=O,,,,val
US03979396,CC(=O)NC1=C(C(=O)O)CSC1CCCCC(=O)N1CCCCC1.CCOC(=O)Cl>>CCOC(=O)C(=O)C1=C(NC(C)=O)C(CCCCC(=O)N2CCCCC2)SC1,,CC(C)=O,O,CCN(CC)CC,,val
US20160122335A1,CC(C)(O)Cn1cnnc1-c1nc(COCOCC[Si](C)(C)C)cs1>>CC(C)(O)Cn1cnnc1-c1nc(CO)cs1,,C1COCCO1,Cl,,,val
US20060128634A1,CC(C)(N)c1ccccc1.CCOC(=O)[C@H](C)OS(=O)(=O)C(F)(F)F>>CCOC(=O)[C@@H](C)NC(C)(C)c1ccccc1,,ClCCl,,,,val
US20110059943A1,CCN(N)C(=O)OC(C)(C)C.CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(N/C(=C/C(=O)C(OC)OC)SC)nc21>>CCN(N/C(=C\C(=O)C(OC)OC)Nc1nc2c(cc(C(=O)N(C3CC3)C3CC3)n2CC)c2c1ncn2C)C(=O)OC(C)(C)C,,CC(=O)O,,,,val
US20070066583A1,COc1cc(N2CCN(C(=O)CCl)CC2)c(F)cc1Cl.O=c1[nH]c2ccc(Cl)cc2o1>>COc1cc(N2CCN(C(=O)Cn3c(=O)oc4cc(Cl)ccc43)CC2)c(F)cc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080027065A1,C[C@H]1CNCCN1C(=O)OC(C)(C)C.Cc1cc(N)ncc1C=O>>Cc1cc(N)ncc1CN1CCN(C(=O)OC(C)(C)C)[C@@H](C)C1,,ClCCCl,,O=C([O-])O.[Na+],,val
US04772600,CC(C)O.Cl.O=C(Cn1c(-c2ccc(Cl)cc2)nc2cccnc21)Nc1cccnc1>>Cl.O.O=C(Cn1c(-c2ccc(Cl)cc2)nc2cccnc21)Nc1cccnc1,,CC(C)O,,,,val
US20150038488A1,CC(=O)OC(C)=O.C[C@@H](Oc1nc(-c2ccc(N3CCNCC3)cc2)cn2ncc(C#N)c12)[C@H]1CNC(=O)C1>>CC(=O)N1CCN(c2ccc(-c3cn4ncc(C#N)c4c(O[C@H](C)[C@H]4CNC(=O)C4)n3)cc2)CC1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20130116250A1,CCCN.COC(=O)c1cc(C(=O)c2ncc3ccccn23)ccc1N.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCNC(=O)Nc1ccc(C(=O)c2ncc3ccccn23)cc1C(=O)OC,,C1COCCO1,O,CCN(CC)CC,,val
US20130324576A1,Cc1nn(C)c(C)c1S(=O)(=O)Cl.Cl.Fc1cc(OC2CCNCC2)ccc1Cl>>Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Oc2ccc(Cl)c(Cl)c2)CC1,,ClCCl,,CCN(CC)CC,,val
US20100137308A1,CN(C)CC(=O)O.COc1ccc(CC2CCNCC2)c(Nc2nc3ccccc3nc2NS(=O)(=O)c2cn(C)cn2)c1.Cl>>COc1ccc(CC2CCN(C(=O)CN(C)C)CC2)c(Nc2nc3ccccc3nc2NS(=O)(=O)c2cn(C)cn2)c1.Cl,CN(C)c1ccncc1,CN(C)C=O,ClCCl,CCN=C=NCCCN(C)C,,val
US20020173659A1,CC1CN(c2ncccn2)CC(C)N1CCC[NH-]>>CC1CN(c2ncccn2)CC(C)N1CCCN,,C1CCOC1,CCOCC,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05436257,C[C@H](COc1ccc(CC2SC(=O)N(C(c3ccccc3)(c3ccccc3)c3ccccc3)C2=O)cc1)NC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>C[C@@H](N)COc1ccc(CC2SC(=O)NC2=O)cc1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20040097566A1,CC(C)(C)[Si](C)(C)Cl.CC1(c2cc(Br)ccc2O)CCCCC1>>CC1(c2cc(Br)ccc2O[Si](C)(C)C(C)(C)C)CCCCC1,CN(C)c1ccncc1,CN(C)C=O,,CCN(CC)CC,O,val
US20150126485A1,CC(C)(C)OC(=O)n1cccc1B1OC(C)(C)C(C)(C)O1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(Br)c1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccc[nH]2)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20140275016A1,CC(=O)Nc1cc(Oc2ccc([N+](=O)[O-])nc2)ccn1>>CC(=O)Nc1cc(Oc2ccc(N)nc2)ccn1,[Zn],CO,,[Cl-].[NH4+],,val
US20050245592A1,CCOc1cc(Br)c(Br)c(F)c1OCC>>CCOc1cc(Br)c(Br)c(F)c1O,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20120040968A1,C1CCNCC1.COc1cc([N+](=O)[O-])ccc1S(=O)(=O)Cl>>COc1cc([N+](=O)[O-])ccc1S(=O)(=O)N1CCCCC1,,C1CCOC1,,Cl,,val
US20130172549A1,CCOC(=O)Cc1cn2c(C(=O)NCC34CC5CC(CC(C5)C3)C4)cccc2n1>>O=C(O)Cc1cn2c(C(=O)NCC34CC5CC(CC(C5)C3)C4)cccc2n1,,CO,O,[Na+].[OH-],,val
US20060173018A1,COCCOC(=O)Cl.Cc1ccc2c(N3CC[C@@H](CN)C3)nc(-c3ccccc3O)nc2c1>>COCCOC(=O)NC[C@@H]1CCN(c2nc(-c3ccccc3O)nc3cc(C)ccc23)C1,,CN(C)C=O,,CCN(CC)CC,,val
US20110144091A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C(N[C@@H]1CCc2ccccc2NC1=O)OCc1ccccc1>>O=C(N[C@@H]1CCc2ccccc2NC1=S)OCc1ccccc1,,C1CCOC1,,CCOCC,,val
US20060063775A1,CC(C)(C)OC(=O)N1CCCC[C@H]1C(=O)O.c1ccc(CN2CCNCC2)cc1>>CC(C)(C)OC(=O)N1CCCC[C@H]1C(=O)N1CCN(Cc2ccccc2)CC1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US05736534,COc1cc2ncnc(Cl)c2cc1OC.O=[N+]([O-])c1ccc2c(c1)NCC2>>COc1cc2ncnc(N3CCc4ccc([N+](=O)[O-])cc43)c2cc1OC,,CC(C)O,,,,val
US20140038999A1,CC(C)C[C@@H](COc1ccc2c(c1)[nH]c(=O)c1cnccc12)NC(=O)OC(C)(C)C>>CC(C)C[C@H](N)COc1ccc2c(c1)[nH]c(=O)c1cnccc12,,ClCCl,,Cl,,val
US20110263612A1,Cc1nc2cc(Cl)c(-c3ccc(N)nc3)cc2o1.O=C(Cl)c1ccccc1Cl>>Cc1nc2cc(Cl)c(-c3ccc(NC(=O)c4ccccc4Cl)nc3)cc2o1,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20030119870A1,Clc1ccncc1.c1ccc2c(c1)CCNC2>>c1ccc2c(c1)CCN(c1ccncc1)C2,,CCOC(C)=O,O,Cl,[Na+].[OH-],val
US06831106B1,CCOC(=O)c1ccc(I)cc1.COCOc1ccc(C)c(B(O)O)c1>>CCOC(=O)c1ccc(-c2cc(O)ccc2C)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20130338066A1,Cc1cccc(C2C(C)(C)OC(N[C@@H](CCO[Si](C)(C)C(C)(C)C)c3ccccc3)=NS2(=O)=O)c1>>Cc1cccc(C2C(C)(C)OC(N[C@@H](CCO)c3ccccc3)=NS2(=O)=O)c1,,CCOC(C)=O,CO,Cl,,val
US20080085898A1,CC(C)(C)OC(=O)Nc1ccc(OC(F)(F)F)cc1Nc1ncc([N+](=O)[O-])c(NC2CCOCC2)n1>>O=[N+]([O-])c1cnc(-n2cnc3ccc(OC(F)(F)F)cc32)nc1NC1CCOCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030176698A1,BrC(Br)(Br)Br.CCCN1C(=O)N2C[C@@H](Cc3ccccc3)N=C2c2c1ncn2Cc1ccccc1>>CCCN1C(=O)N2C[C@@H](Cc3ccccc3)N=C2c2c1nc(Br)n2Cc1ccccc1,,C1CCCCC1,C1CCOC1,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US05342846,O=C(O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O.c1cn(C2CNC2)nn1>>O=C(O)c1cn(C2CC2)c2c(F)c(N3CC(n4ccnn4)C3)c(F)cc2c1=O,,c1ccncc1,,C1CCC2=NCCCN2CC1,Cl,val
US04788206,CCCCC/C(=C/C=C/C(=O)Oc1ccc([N+](=O)[O-])cc1)c1ccc(OC)cc1.NCCCCc1cccnc1>>CCCCC/C(=C/C=C/C(=O)NCCCCc1cccnc1)c1ccc(OC)cc1,,C1CCOC1,,,,val
US20140005168A1,COC1(C)CN(C(=O)OC(C)(C)C)CCN(c2cccc(-n3ncc4cnc(-c5cn[nH]c5)cc43)n2)C1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>COC1(C)CN(C(=O)OC(C)(C)C)CCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1,,CN(C)C=O,,,,val
US20060106089A1,Nc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1.O=S(=O)(Cl)c1cc2ccccc2s1>>O=S(=O)(Nc1ccccc1NS(=O)(=O)c1cc2ccccc2s1)c1ccc(Cl)cc1,,ClCCl,c1ccncc1,,,val
US20080096877A1,COC(OC)C(CN)SCc1ccccc1.Cc1ccc(N(C)S(=O)(=O)c2cccs2)c2[nH]c(C(=O)O)cc12>>COC(OC)C(CNC(=O)c1cc2c(C)ccc(N(C)S(=O)(=O)c3cccs3)c2[nH]1)SCc1ccccc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100041715A1,O=C(NC(O)C(Cl)(Cl)Cl)c1cc(Br)co1.O=C=Nc1ccc(Cl)cc1>>O=C(NC(Nc1ccc(Cl)cc1)C(Cl)(Cl)Cl)c1cc(Br)co1,CCN(CC)CC,c1ccccc1,,,,val
US20100261698A1,C=Cc1cncc(-c2cc3ccccc3n2C)c1>>CCc1cncc(-c2cc3ccccc3n2C)c1,[Pd],CO,,,,val
US20100105663A1,COC(=O)c1ccc(C2OCC(C)(C)CO2)c([N+](=O)[O-])c1>>CC1(C)COC(c2ccc(C(=O)O)cc2[N+](=O)[O-])OC1,,CO,O,Cl,[Li+].[OH-],val
US20110183979A1,CCOC(=O)c1nc(Br)ccc1N.N#C[Cu]>>CCOC(=O)c1nc(C#N)ccc1N,,CN(C)C=O,,,,val
US20050250782A1,CCOC(=O)c1c(Nc2ccc(C)cc2F)c(C)c(=O)n(C)c1C.O=C1CCC(=O)N1Br>>CCOC(=O)c1c(Nc2ccc(C)cc2F)c(C)c(=O)n(C)c1CBr,,CCOC(C)=O,CN(C)C=O,,,val
US20080070929A1,C#CCNc1ccc2c(c1)OC(F)(F)O2.CC(=O)N=C=S>>C=C1CN(c2ccc3c(c2)OC(F)(F)O3)/C(=N/C(C)=O)S1,,C1CCOC1,,,,val
US04223169,BrBr.COc1ccccc1>>COc1ccc(Br)cc1,,ClC(Cl)Cl,,,,val
US20050143579A1,CC(C)(C)OC(=O)N1CCNCC1.ClCCl.OC1OC2CCCCC2C1c1cccc(Cl)c1>>Cl.Cl.OC1CCCCC1C(CN1CCNCC1)c1cccc(Cl)c1,,CC(Cl)Cl,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20160168148A1,Cc1nc2c(ccc3nnc(C)n32)n1Cc1ccccc1.O=C1CCC(=O)N1Cl>>Cc1nc2c(cc(Cl)c3nnc(C)n32)n1Cc1ccccc1,,ClCCCl,ClCCl,,,val
US06444679B1,CCCC(C)CN1CCC(c2cccc(C#N)c2)(c2ncc(C(=O)N(CC)CC)cn2)CC1.C[Si](C)(C)N=[N+]=[N-]>>CCCC(C)CN1CCC(c2cccc(-c3nnn[nH]3)c2)(c2ncc(C(=O)N(CC)CC)cn2)CC1,,Cc1ccccc1,,,,val
US03950393,C1COCCN1.COc1ccc(N)c(CO)c1>>COc1ccc(N)c(CN2CCOCC2)c1,,ClCCl,,O=S(Cl)Cl,,val
US04532349,O=C(CCl)Nc1ccc(S(=O)(=O)c2cccc(Cl)c2)cc1.[N-]=[N+]=[N-]>>[N-]=[N+]=NCC(=O)Nc1ccc(S(=O)(=O)c2cccc(Cl)c2)cc1,,CCO,,O,,val
US20150065704A1,CC(=O)[C@]1(O)C(=O)OC(=O)[C@@]1(O)C(C)=O.CCOC(C)=O.NC(=O)N1c2ccccc2CC(O)c2ccccc21>>NC(=O)N1c2ccccc2C[C@H](O)c2ccccc21.O=C(O)C(O)C(O)C(=O)O,,O,,c1ccncc1,,val
US20140194415A1,CC(=O)OC(C)=O.OCCc1ccc(Br)cc1F>>CC(=O)OCCc1ccc(Br)cc1F,CN(C)c1ccncc1,ClCCl,c1ccncc1,,,val
US20020128383A1,COC(=O)Cl.NS(=O)(=O)c1cccc([N+](=O)[O-])c1>>COC(=O)NS(=O)(=O)c1cccc([N+](=O)[O-])c1,,C1CCOC1,C1CCOC1,Cl,[H-].[Na+],val
US20080108613A1,C1CCNC1.ClCCOc1n[nH]c2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12>>Clc1cc(Nc2ncnc3[nH]nc(OCCN4CCCC4)c23)ccc1OCc1ccccn1,,CC(=O)N(C)C,,[I-].[K+],,val
US20120108583A1,COC(=O)c1cc2nc(Nc3c(F)cccc3Cl)[nH]c2c2nc(C3CC3)oc12.Nc1cc(C(F)(F)F)ccc1F>>O=C(Nc1cc(C(F)(F)F)ccc1F)c1cc2nc(Nc3c(F)cccc3Cl)[nH]c2c2nc(C3CC3)oc12,,Cc1ccccc1,,C[Al](C)C,,val
US20100087427A1,COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2O)C(C)C)ccc1OC.ClCc1cc(-c2ccc(Cl)cc2)no1>>COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2OCc2cc(-c3ccc(Cl)cc3)no2)C(C)C)ccc1OC,,O,,CC#N,CC#N,val
US04062869,Cc1cccc(O)c1.O=C(Cl)C(=O)c1c[nH]c2ccccc12>>Cc1cccc(OC(=O)C(=O)c2c[nH]c3ccccc23)c1,,CCOCC,,c1ccncc1,,val
US20130178459A1,CCC(CNC(=O)OC(C)(C)C)c1ccc(-c2c(OC)ccc3[nH]c(=O)c4sccc4c23)cc1.O=C1CCC(=O)N1Cl>>CCC(CNC(=O)OC(C)(C)C)c1ccc(-c2c(OC)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1,,CN(C)C=O,,,,val
US06486158B1,Clc1cccc(CBr)c1.Sc1nnc(-c2ccccc2)c2ccccc12>>Clc1cccc(CSc2nnc(-c3ccccc3)c3ccccc23)c1,,CCO,,[K+].[OH-],,val
US05294713,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O.CCOC(CNCC#N)OCC>>CC(C)(C)OC(=O)N1C=CN(CC#N)C(=O)[C@@H]1Cc1ccccc1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20060084673A1,CC#N.Clc1ccccc1CBr.NC1=NC(=O)CN1C(=O)OCc1ccccc1>>C=C1CN(C(=O)OCc2ccccc2)C(NCc2ccccc2Cl)=N1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130123289A1,CC(C)(CNc1ncc(Br)cn1)c1ccc(F)cc1.N#Cc1cc(B(O)O)ccc1F>>CC(C)(CNc1ncc(-c2ccc(F)c(C#N)c2)cn1)c1ccc(F)cc1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20120289505A1,COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(N)cc3)ccc2C1=O.O=C(Br)c1ccccc1>>COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(NC(=O)c4ccccc4)cc3)ccc2C1=O,,ClCCl,,c1ccncc1,,val
US20030232820A1,BrCc1ccccc1.C[C@H](O)C(=O)O>>C[C@H](O)C(=O)OCc1ccccc1,,CO,,C1CCC2=NCCCN2CC1,,val
US20100273775A1,CI.Fc1ccc(-c2nn3c(c2-c2ccnc(Cl)n2)CCCN3)cc1>>CN1CCCc2c(-c3ccnc(Cl)n3)c(-c3ccc(F)cc3)nn21,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20070205714A1,CC1(O)c2cc(Br)ccc2-c2ccc(Br)cc2C1(C)O>>CC1(C)C(=O)c2cc(Br)ccc2-c2ccc(Br)cc21,,CC(=O)O,,O=C(O)C(F)(F)F,,val
US20060178532A1,CC(C)N(NC(=O)c1ccccc1)C(=O)COc1ccc(F)cc1Br.OB(O)c1ccccc1F>>CC(C)N(NC(=O)c1ccccc1)C(=O)COc1ccc(F)cc1-c1ccccc1F,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US03978116,COC(=O)Cc1ccccc1.O=C1CCC(=O)O1>>COC(=O)Cc1ccc(C(=O)CCC(=O)O)cc1,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20060111375A1,CCOC(=O)c1cc(F)ccc1O.COc1cc2nccc(Cl)c2cc1OC>>CCOC(=O)c1cc(F)ccc1Oc1ccnc2cc(OC)c(OC)cc12,CN(C)c1ccncc1,Clc1ccccc1Cl,,,,val
US20100130446A1,CNCCO.O=Cc1ccc(-c2ccc(C(CC3CCOCC3)c3ccc(S(=O)(=O)C4CC4)cc3)[nH]2)nc1>>CN(CCO)Cc1ccc(-c2ccc(C(CC3CCOCC3)c3ccc(S(=O)(=O)C4CC4)cc3)[nH]2)nc1,,CCOC(C)=O,ClCCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080194647A1,CN(C)C=O.N#Cc1cccc(C#Cc2cncc(Br)c2)c1>>N#Cc1cccc(C#Cc2cncc(C=O)c2)c1,,C1CCOC1,CCOC(C)=O,CC(C)[Mg]Cl,,val
US20080009513A1,CC(=O)CI.Nc1ccc(Cl)cc1Cl>>CC(=O)CNc1ccc(Cl)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05179091,O=C(C=Cc1ccccc1)c1ccc2[nH]c(=O)oc2c1>>O=C1C=C(c2ccccc2)c2cc3[nH]c(=O)oc3cc21,,ClC(Cl)Cl,,,,val
US20020091135A1,CCOC(=O)C(=O)NC(C)C(=O)c1ccccc1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CCOC(=O)c1nc(C)c(-c2ccccc2)s1,,ClC(Cl)Cl,O,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20130172318A1,Cc1cc(C)cc(C(=O)Cl)c1.NC1CCCNC1=O>>Cc1cc(C)cc(C(=O)NC2CCCNC2=O)c1,,ClC(Cl)Cl,,Cl,O=C([O-])[O-].[K+].[K+],val
US20110178031A1,CCOC(=O)CBr.O=C(Nc1nc(=O)[nH]cc1I)c1ccccc1>>CCOC(=O)Cn1cc(I)c(NC(=O)c2ccccc2)nc1=O,,CN(C)C=O,,[H-].[Na+],,val
US20110144056A1,CC(C)(C)OC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccc(-c2ccnn2C2CCCCO2)cn1>>CC(C)(C)OC(=O)/C=C/c1ccc(-c2ccnn2C2CCCCO2)cn1,,ClCCl,,,,val
US20020099212A1,Cc1ccnc(C)c1.O=Cc1ccc(-c2ccccc2)cc1>>Cc1ccnc(/C=C/c2ccc(-c3ccccc3)cc2)c1,,CC(=O)OC(C)=O,,,,val
US20120165310A1,Nc1ncnc2c1c(-c1cccc(OCC34CCC(CC3)O4)c1)cn2C1CC(=O)C1>>Nc1ncnc2c1c(-c1cccc(OCC34CCC(CC3)O4)c1)cn2[C@@H]1C[C@H](O)C1,,CO,,[BH4-].[Na+],,val
US20100295029A1,Brc1cccc(I)c1.OB(O)c1cc2c3ccccc3c3ccccc3c2c2ccccc12>>Brc1cccc(-c2cc3c4ccccc4c4ccccc4c3c3ccccc23)c1,,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20100280030A1,COC(=O)c1ccc2oc(=O)n(Cc3ccc([N+](=O)[O-])c([N+](=O)[O-])c3)c2c1>>COC(=O)c1ccc2oc(=O)n(Cc3ccc(N)c(N)c3)c2c1,[Ni],C1CCOC1,,,,val
US04568381,COc1nc(N)nc(OC)n1.O=S(=O)(N=C=S)c1ccccc1-c1ccccc1>>COc1nc(NC(=S)NS(=O)(=O)c2ccccc2-c2ccccc2)nc(OC)n1,,Cc1ccccc1,,,,val
US20110021434A1,COC(=O)[C@@H]1CSCCCCOc2ccc(cc2)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1.Cl>>COC(=O)[C@@H]1CSCCCCOc2ccc(cc2)C[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N1.Cl,,C1COCCO1,,,,val
US05767131,N#CCCN1CCC(C2CCCCC2)CC1>>NCCCN1CCC(C2CCCCC2)CC1,,C1CCOC1,,CCOCC,Cl,val
US05277838,CCC(C)CO.C[SiH](C)c1ccc(C(=O)Cl)cc1>>CCC(C)COC(=O)c1ccc([SiH](C)C)cc1,,c1ccncc1,,Cl,,val
US05254565,O=[N+]([O-])c1cnc2ccc(C(F)(F)F)cc2c1-c1ccccc1>>Nc1cnc2ccc(C(F)(F)F)cc2c1-c1ccccc1,,Cl,,[Na+].[OH-],,val
US20020173527A1,CNOC.COc1ccc(Cn2cc(C)c3ccc(C(=O)Cl)cc32)cc1>>COc1ccc(Cn2cc(C)c3ccc(C(=O)N(C)OC)cc32)cc1,,ClC(Cl)Cl,,Cl,c1ccncc1,val
US20040106606A1,CC(C)[C@@](O)(CCc1ccc(F)cc1)CC(=O)O.C[C@H](N)c1ccccc1>>Cc1cc(F)ccc1CC[C@](O)(CC(=O)O)C(C)C,,CCOC(C)=O,,,,val
US20130102585A1,CC(=O)N1c2ccc(Br)cc2CCC1C(=O)N1CC(N2CCN(C(=O)C(F)(F)F)CC2)C1>>CC(=O)N1c2ccc(Br)cc2CCC1C(=O)N1CC(N2CCNCC2)C1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20020115863A1,CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C)[C@@H](F)C(=O)OC>>CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)O)[C@@H](F)C(=O)OC,,C1COCCO1,,Cl,,val
US20150119393A1,CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@H](Oc3nc4cc(Cl)c(-c5ccc([C@@H]6CC[C@@H](N=[N+]=[N-])CC6)cc5)nc4n3COCC[Si](C)(C)C)CO[C@H]12>>CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@H](Oc3nc4cc(Cl)c(-c5ccc([C@@H]6CC[C@@H](N)CC6)cc5)nc4n3COCC[Si](C)(C)C)CO[C@H]12,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04579857,COC(=O)SCl.O=C1NCC(c2ccccc2)N1CCCS>>COC(=O)SSCCCN1C(=O)NCC1c1ccccc1,,CO,,,,val
US20070037817A1,N#Cc1nccnc1Cl.OC[C@H]1CC[C@H]2CNCCN12>>N#Cc1nccnc1N1CCN2[C@@H](CO)CC[C@H]2C1,,C1CCOC1,,CCN(CC)CC,,val
US20100190814A1,CCC(CC)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)Nc1cc(Cl)ccc12)C(=O)NS(C)(=O)=O.COC(=O)Cl>>CCC(CC)(Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)N(C(=O)OC)c1cc(Cl)ccc12)C(=O)NS(C)(=O)=O,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,,,val
US20040147748A1,COC(=O)c1cnc(C=CN(C)C)cn1.O>>COC(=O)c1cnc(C=O)cn1,,C1CCOC1,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20100197651A1,COC(=O)c1nn(-c2cccc(C(F)(F)F)c2)ccc1=O>>O=c1ccn(-c2cccc(C(F)(F)F)c2)nc1CO,,C1CCOC1,Cl,CC(C)C[AlH]CC(C)C,,val
US20110046133A1,COC(=O)COc1cc(Cl)c(-c2nc3ccc(C(=O)Nc4ccc5ccccc5n4)cc3[nH]2)c(Cl)c1>>O=C(O)COc1cc(Cl)c(-c2nc3ccc(C(=O)Nc4ccc5ccccc5n4)cc3[nH]2)c(Cl)c1,,CO,,Cl,[Na+].[OH-],val
US20130012518A1,CCCCS(=O)(=O)Cl.Cc1ccc(N)cc1N1CCc2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc2C1>>CCCCS(=O)(=O)Nc1ccc(C)c(N2CCc3nc(Nc4ccc(N5CCN(C)CC5)cc4)ncc3C2)c1,,c1ccncc1,,,,val
US20090192156A1,O=CN1CCC(OC(F)F)CC1>>FC(F)OC1CCNCC1,,O,,[K+].[OH-],,val
US20100076187A1,CC(C)(C)OC(=O)NC1CCNCC1.Fc1cc(F)cc(CBr)c1>>NC1CCN(Cc2cc(F)cc(F)c2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20030125371A1,CCOC(=O)C(=O)c1cn(Cc2ccccc2)c2ccc(-c3ccc(F)c(Cl)c3)cc12>>O=C(O)C(=O)c1cn(Cc2ccccc2)c2ccc(-c3ccc(F)c(Cl)c3)cc12,,C1CCOC1,O,[K+].[OH-],,val
US20080009512A1,CCOC(=O)C(NC(C)=O)C(=O)OCC.Cc1cccc([N+](=O)[O-])c1CBr>>CCOC(=O)C(Cc1c(C)cccc1[N+](=O)[O-])(NC(C)=O)C(=O)OCC,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20130178478A1,CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.Cn1cnc2c(Nc3cc(Cl)nnc3C(N)=O)cccc21>>Cn1cnc2c(Nc3cc(N[C@@H]4CCCC[C@@H]4NC(=O)OC(C)(C)C)nnc3C(N)=O)cccc21,,CN1CCCC1=O,,,,val
US20140005213A1,CC(C)(C)OC(=O)N[C@H]1CCN(C(c2ccc3nnc(-c4ccc5ccc(C(=O)O)cc5n4)n3c2)C(F)(F)F)C1.CC(C)N>>CC(C)NC(=O)c1ccc2ccc(-c3nnc4ccc(C(N5CC[C@H](NC(=O)OC(C)(C)C)C5)C(F)(F)F)cn34)nc2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05834506,CC(C)(C)[Si](C)(C)OCCOc1ccc(C(=O)CCc2ccccc2)cc1.COC(=O)CC(C)=O>>CC(C)(C)[Si](C)(C)OCCOc1ccc(C2(CCc3ccccc3)CC(O)=CC(=O)O2)cc1,,C1CCOC1,,[Li]CCCC,[H-].[Na+],val
US05106871,CC(C)=CCCl.O=Cc1ccc(O)cc1>>CC(C)=CCc1cc(C=O)ccc1O,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20090305998A1,CC1(C)OC[C@H](CON)O1.Cc1nc(N)nc2c1C(=S)N[C@@H](c1ccc(F)cc1Br)C2>>Cc1nc(N)nc2c1/C(=N/OC[C@H]1COC(C)(C)O1)N[C@@H](c1ccc(F)cc1Br)C2,,C1COCCO1,,,,val
US04559348,C1CCNCC1.Cc1cc(Cl)c2[nH]ncc2n1>>Cc1cc(N2CCCCC2)c2[nH]ncc2n1,,C1CCNCC1,,O=C(O)C(F)(F)F,,val
US05106853,C1CC1c1noc([C@H]2CN3CC[C@H]2C3)n1.O=C(O)/C=C\C(=O)O>>C1CC1c1noc([C@H]2CN3CC[C@H]2C3)n1.O=C(O)/C=C\C(=O)O,,CCOCC,CO,,,val
US07553969B1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H](Cc1ccc(O)c(F)c1)C(=O)O>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)O,,C1COCCO1,O,,,val
US20140088101A1,COC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O.NCCS(N)(=O)=O>>NS(=O)(=O)CCNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O,,CCO,,Cl,C[O-].[Na+],val
US05808062,O=Cc1ccccc1.O=c1oc(-c2ccccc2)cc(O)c1SSc1c(O)cc(-c2ccccc2)oc1=O.Sc1ccc2ccccc2c1>>O=c1oc(-c2ccccc2)cc(O)c1C(Sc1ccc2ccccc2c1)c1ccccc1,,CC(=O)O,CCO,C1CCNCC1,,val
US04785017,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=CC1CCc2ccc(OCc3ccccc3)cc2O1>>C=CC(=O)OCC.c1ccc(COc2ccc3c(c2)OCCC3)cc1,,Cc1ccccc1,,,,val
US04329518,Cc1cccc(-c2ccccc2)c1F.O=C1CCC(=O)N1Br>>Fc1c(CBr)cccc1-c1ccccc1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20100055608A1,O=C(Cl)CCl.O=S(=O)([O-])C(F)(F)C(O)C(F)(F)F.c1ccc([S+](c2ccccc2)c2ccccc2)cc1>>O=C(CCl)OC(C(F)(F)F)C(F)(F)S(=O)(=O)[O-].c1ccc([S+](c2ccccc2)c2ccccc2)cc1,,CC#N,,c1ccncc1,,val
US06172085B2,BrC(Br)(Br)Br.Cc1c(C)c2c(c(C)c1NC(=O)OC(C)(C)C)CC(C)(CCO)O2>>Cc1c(C)c2c(c(C)c1NC(=O)OC(C)(C)C)CC(C)(CCBr)O2,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070066820A1,ClCc1ncon1.Clc1ccc(Oc2ccc(OC[C@@H]3CCCCN3)cc2)cc1>>Clc1ccc(Oc2ccc(OC[C@@H]3CCCCN3Cc3ncno3)cc2)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20070037846A1,CCS(=O)(=O)Cl.Cc1c(O)ccc(C=O)c1C>>CCS(=O)(=O)Oc1ccc(C=O)c(C)c1C,,ClCCl,,CCN(CC)CC,,val
US20120157452A1,COc1n[nH]c2ncc([N+](=O)[O-])cc12>>COc1n[nH]c2ncc(N)cc12,[Pd],CCOC(C)=O,CO,[H][H],,val
US05273680,CCCCCCBr.Oc1ccc(Br)c(F)c1>>CCCCCCOc1ccc(Br)c(F)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20030119839A1,COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1O.O=C1Nc2cc(Br)ccc2/C1=C/c1ccccn1>>COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2ccccn2)ccc1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,COCCOC,[Cs+].[F-],,val
US05281747,Cc1ccc(S(=O)(=O)OC[C@@H](O)CP(C)(=O)OCC(C)C)cc1.[N-]=[N+]=[N-]>>CC(C)COP(C)(=O)C[C@H](O)CN=[N+]=[N-],,CN(C)C=O,,O,,val
US20070185126A1,CCOc1ccccc1C1(Cl)C(=O)Nc2ccc(OC)cc21.N>>CCOc1ccccc1C1(N)C(=O)Nc2ccc(OC)cc21,,CCO,ClCCl,,,val
US20150111877A1,CC1COc2ncc(N)cc2N1.O=C(Cl)c1c(F)cccc1Cl>>CC1COc2ncc(NC(=O)c3c(F)cccc3Cl)cc2N1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20040209921A1,Cc1cc(Cl)cnc1CN(Cc1ncccc1C(C)(C)c1ccc(F)cc1)C1CCNCC1.O=C(Nc1ncc[nH]1)n1ccnc1>>Cc1cc(Cl)cnc1CN(Cc1ncccc1C(C)(C)c1ccc(F)cc1)C1CCN(C(=O)Nc2ncc[nH]2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130150341A1,Cc1cnc(C2=CCN(Cc3ccccc3)CC2)o1>>Cc1cnc(C2CCNCC2)o1,[Pd],C1CCOC1,CCO,,,val
US05672597,NCCCOc1cccc(CN2CCCCC2)c1.O=C(O)CS(=O)CCNC(=O)c1ccco1>>O=C(CS(=O)CCNC(=O)c1ccco1)NCCCOc1cccc(CN2CCCCC2)c1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20020156087A1,CCC[Mg]Cl.O=C(Cl)c1ccc(Cl)cc1Cl>>CCCC(=O)c1ccc(Cl)cc1Cl,[Cu]I,C1CCOC1,,,,val
US20100190814A1,COC(=O)C(C)(C)Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)N(COCC[Si](C)(C)C)c1cc(Cl)ccc12>>COC(=O)C(C)(C)Oc1ccc(Cl)cc1C1CC(=O)NC(c2cc(F)ccc2C)C12C(=O)N(CO)c1cc(Cl)ccc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020082265A1,CC(C)[N+](=O)[O-].CC1(C)CCC(C)(C)c2cc(CBr)c(F)cc21>>CC1(C)CCC(C)(C)c2cc(C=O)c(F)cc21,,CCO,,[Na],,val
US20120220013A1,Cc1ccc(OS(=O)(=O)OCCOCCNC(=O)OC(C)(C)C)cc1.OCCc1ccc(O)cc1>>CC(C)(C)OC(=O)NCCOCCOc1ccc(CCO)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080280992A1,CCNC.COC(OC)OC.Cc1cc(Br)c(C)cc1N>>CCN(C)C=Nc1cc(C)c(Br)cc1C,,COC(C)(C)C,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080096877A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.COc1ccccc1S(=O)(=O)N(C)c1cccc2cc(C(N)=O)[nH]c12>>COc1ccccc1S(=O)(=O)N(C)c1cccc2cc(C(N)=S)[nH]c12,,C1CCOC1,,,,val
US20160237059A1,CCOC(=O)C(F)(F)F.CCOC(=O)COc1ccc(Cl)c(C(F)(F)F)c1>>CCOC(=O)C(Oc1ccc(Cl)c(C(F)(F)F)c1)C(=O)C(F)(F)F,,Cc1ccccc1,,Cl,[H-].[Na+],val
US20140031364A1,Cc1onc(-c2ccccc2F)c1C(=O)O.Fc1ccc(N2CCNCC2)cc1>>Cc1onc(-c2ccccc2F)c1C(=O)N1CCN(c2ccc(F)cc2)CC1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20140288123A1,COC(=O)c1ccc(C(C)O)cc1.Oc1ccccc1F>>COC(=O)c1ccc(C(C)Oc2ccccc2F)cc1,,C1CCOC1,O,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100105904A1,BrCCCBr.COc1cc(NC(=O)NCc2ccc(Cl)c(Cl)c2)ccc1-n1cnc(C)c1>>COc1cc(N2CCCN(Cc3ccc(Cl)c(Cl)c3)C2=O)ccc1-n1cnc(C)c1,,C1CCOC1,,CCOC(C)=O,O,val
US20040072860A1,N#Cc1ccc(CN2CCNCC2=O)cc1.O=C(Cl)COc1ccc(Cl)cc1>>N#Cc1ccc(CN2CCN(C(=O)COc3ccc(Cl)cc3)CC2=O)cc1,,CC#N,,CN1CCOCC1,,val
US20080021064A1,ClCc1ccnc2ccccc12.O=C(O)c1cccnc1S>>O=C(O)c1cccnc1SCc1ccnc2ccccc12,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,O,val
US20100249139A1,C=CCN(CC=C)c1ccc(C(C)C(O)(c2ccnc(Cl)c2)C(F)(F)F)c(Cl)c1>>CC(c1ccc(N)cc1Cl)C(O)(c1ccnc(Cl)c1)C(F)(F)F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,,[Na+].[OH-],,val
US20140005213A1,CC(C)(C)OC(=O)N(CCF)[C@H]1CCN(C(=O)OCc2ccccc2)C1>>CC(C)(C)OC(=O)N(CCF)[C@H]1CCNC1,[Pd],CCO,CO,,,val
US20130040930A1,Cc1ccc(N2CCN(C(=O)c3ccc([N+](=O)[O-])cc3NS(C)(=O)=O)CC2)c(C)c1>>Cc1ccc(N2CCN(C(=O)c3ccc(N)cc3NS(C)(=O)=O)CC2)c(C)c1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20100113410A1,COc1c(C)cnc(CN2N=C3CC(O)C4=C3C(=N2)C(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)=NSC4)c1C>>COc1c(C)cnc(CN2N=C3CC(O)C4=C3C(=N2)C(N)=NSC4)c1C,,C1COCCO1,CO,Cl,ClCCl,val
US05877207,CCOC(=O)c1ccc(NC(=O)c2cc(Br)c3c(c2)C(c2ccc(C)cc2)CC(C)(C)O3)cc1F>>Cc1ccc(C2CC(C)(C)Oc3c(Br)cc(C(=O)Nc4ccc(C(=O)O)c(F)c4)cc32)cc1,,CCO,,Cl,[Na+].[OH-],val
US20030176418A1,Cc1ccc2c(c1)OCC(=O)N2.ClCCCI>>Cc1ccc2c(c1)OCC(=O)N2CCCCl,,CCCCCCC,CCOC(C)=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040138269A1,CCOC(=O)c1[nH]c(C)c(-c2ccc(C(=O)O)cc2)c1C.Nc1ccc(N2CCOCC2)cc1>>CCOC(=O)c1[nH]c(C)c(-c2ccc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc2)c1C,CN(C)C=O,CCOC(C)=O,ClCCl,O=C(Cl)C(=O)Cl,O=C([O-])O.[Na+],val
US06203839B1,C=CCC(OC(C)=O)c1ccc(OC(C)=O)cc1>>CCCC(OC(C)=O)c1ccc(OC(C)=O)cc1,O=[Pt]=O,CCO,,,,val
US04243406,CCOC=C(C(=O)OC)C(=O)c1cccc(C(F)(F)F)c1.NO>>COC(=O)c1cnoc1-c1cccc(C(F)(F)F)c1,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20090105258A1,C=Cc1cc(CNC(=O)OC(C)(C)C)cc(C(F)(F)F)c1N.CS(=O)(=O)Cl>>C=Cc1cc(CNC(=O)OC(C)(C)C)cc(C(F)(F)F)c1NS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US20150025070A1,CCOC(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1>>O=C(O)CN1CCC(C(=O)c2ccc(F)cc2)CC1,,CCO,O,Cl,[Na+].[OH-],val
US20130172556A1,CC(=O)CS(C)(=O)=O.CCc1cc(C)cc(CC)c1C(=O)C(=O)N(C)N>>CCc1cc(C)cc(CC)c1-c1c(S(C)(=O)=O)c(C)nn(C)c1=O,,Cc1ccccc1,,,,val
US20100087427A1,COCCCOc1cc(C(=O)O)ccc1OC.O=C(Cl)C(=O)Cl>>COCCCOc1cc(C(=O)Cl)ccc1OC,,ClCCl,,,,val
US20120202785A1,Nc1ccncn1.O=[N+]([O-])c1ccc(F)cc1F>>O=[N+]([O-])c1ccc(F)cc1Nc1ccncn1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20020137782A1,CCOC(=O)C[C@@H](C)c1ccc(N)cc1.COc1cc(CC(=O)O)cc2oc(Nc3ccccc3C)nc12>>CCOC(=O)C[C@@H](C)c1ccc(NC(=O)Cc2cc(OC)c3nc(Nc4ccccc4C)oc3c2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030139418A1,O=C(O)c1ccc(C=CCc2ccccc2Cc2ccccc2)cc1>>O=C(O)c1ccc(CCCc2ccccc2Cc2ccccc2)cc1,[Pd],C1CCOC1,,,,val
US20040110742A1,Brc1ccccc1COc1ccccc1N[C@@H]1CCN(CCc2ccc(N3CCCC3)cc2)C1>>c1ccc2c(c1)COc1ccccc1N2[C@@H]1CCN(CCc2ccc(N3CCCC3)cc2)C1,Br[Cu]Br,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20100286145A1,CC(C)c1cc(O)cc(C=O)c1.O=C(Cl)N1CCOCC1>>CC(C)c1cc(C=O)cc(OC(=O)N2CCOCC2)c1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US04426380,C=CC(C)c1cc(C)c(-n2cccc2)cc1O.CC(=O)OC(C)=O>>C=CC(C)c1cc(C)c(-n2cccc2)cc1OC(C)=O,c1ccncc1,,,,,val
US20060084643A1,CCc1cc(C#N)c(N)s1.O=[N+]([O-])c1ccc(F)cc1F>>CCc1cc(C#N)c(Nc2cc(F)ccc2[N+](=O)[O-])s1,,C1CCOC1,,[H-].[Na+],,val
US20060135773A1,COc1ccccc1S(=O)(=O)Cl.NCC1CCCCCC1>>COc1ccccc1S(=O)(=O)NCC1CCCCCC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060257987A1,CCc1ccc(OC)cc1.O=C(Cl)C1CC1>>CCc1ccc(O)c(C(=O)C2CC2)c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080269335A1,CCOC(=O)CBr.Oc1ccc(C(F)(F)F)cc1C1C=CCCC1>>CCOC(=O)COc1ccc(C(F)(F)F)cc1C1C=CCCC1,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US06518257B1,CC(=O)Nc1cccc(B(O)O)c1.CC(C)C(O)(c1ccc(Br)cc1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CC(=O)Nc1cccc(-c2ccc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20120053173A1,CCCCCCC(Nc1ccc(C(=O)NCCC(=O)OCC)cc1)c1oc2ccc(OC)cc2c1C>>CCCCCCC(Nc1ccc(C(=O)NCCC(=O)O)cc1)c1oc2ccc(OC)cc2c1C,,CCO,,C1CCOC1,[Na+].[OH-],val
US20090018156A1,CCn1cc(-c2ccnc3[nH]c(C(=O)[O-])cc23)c(-c2cccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c2)n1>>CCn1cc(-c2ccnc3[nH]c(C(=O)O)cc23)c(-c2cccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c2)n1,,CO,,[Na+].[OH-],,val
US20040010007A1,Cc1nc(Cl)c([N+](=O)[O-])c(NCCOc2ccccc2)c1C.Oc1ccccc1>>Cc1nc(Oc2ccccc2)c([N+](=O)[O-])c(NCCOc2ccccc2)c1C,,COCCOCCOC,,[H][H],[H-].[Na+],val
US05273999,COC(=O)CCc1cc(C(C)=O)ccc1OCCCCCOC(C)=O>>COC(=O)CCc1cccc(C(C)=O)c1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04421928,CO.COC(=O)CC(C(Cl)OC)C(C)(C)Cl>>COC(=O)CC(C(OC)OC)C(C)(C)Cl,,CO,,O=C([O-])O.[Na+],,val
US20060135530A1,CON(C)C(=O)c1csc(-c2ccc3nc(CC(C)C)c(CNC(=O)OC(C)(C)C)c(-c4ccc(C)cc4)c3c2)n1.C[Mg]Br>>CC(=O)c1csc(-c2ccc3nc(CC(C)C)c(CNC(=O)OC(C)(C)C)c(-c4ccc(C)cc4)c3c2)n1,,C1CCOC1,,O,,val
US20140011800A1,CC1(C)CNCCC1Nc1c(C(N)=O)cnn2cc(Br)cc12.N#Cc1ccc(Cl)nn1>>CC1(C)CN(c2ccc(C#N)nn2)CCC1Nc1c(C(N)=O)cnn2cc(Br)cc12,,CN(C)C=O,O,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US05208247,CCCCCCCCCCCCCCBr.COC(=O)Cc1ccc(O)c(F)c1>>CCCCCCCCCCCCCCOc1ccc(CC(=O)OC)cc1F,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20020143034A1,Cl.Cl.N[C@H](CO)Cc1ccc(Oc2ncccn2)cc1.c1ccc(OC[C@@H]2CO2)cc1>>Cl.Cl.OC[C@H](Cc1ccc(Oc2ncccn2)cc1)NC[C@H](O)COc1ccccc1,,CCO,,CCN(C(C)C)C(C)C,,val
US06300363B1,CCOC(=O)n1c(C(=O)c2ccccc2)c(NC(C)=O)c2cc([N+](=O)[O-])ccc21>>CCOC(=O)n1c(C(=O)c2ccccc2)c(NC(C)=O)c2cc(N)ccc21,[Pd],CCOC(C)=O,,,,val
US03994884,O=C(COc1ccccc1)N[C@@H]1C(=O)N2C(C(=O)OCC(Cl)(Cl)Cl)=C(CBr)CS[C@H]12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(COc1ccccc1)N[C@@H]1C(=O)N2C(C(=O)OCC(Cl)(Cl)Cl)=C(C[P+](c3ccccc3)(c3ccccc3)c3ccccc3)CS[C@H]12.[Br-],,CCOC(C)=O,,,,val
US20030171543A1,CCCC(=O)Oc1ccc([N+](=O)[O-])cc1.O>>CCCC(=O)[O-].O=[N+]([O-])c1ccc([O-])cc1,,O,,,,val
US20040138065A1,FC(F)(F)CCBr.N#CC(C#N)Cc1ccc(OC(F)(F)F)cc1>>N#CC(C#N)(CCC(F)(F)F)Cc1ccc(OC(F)(F)F)cc1,,CN(C)C=O,,[H-].[Na+],,val
US04344948,COc1ccc(C(=O)CN2CCC(N3Cc4ccccc4NC3=O)CC2)cc1OC>>COc1ccc(C(O)CN2CCC(N3Cc4ccccc4NC3=O)CC2)cc1OC,,CO,,[BH4-].[Na+],,val
US20070099114A1,C=C(C)C(=O)Cl.OC(C(F)(F)F)C(F)(F)C(O)(C(F)(F)F)C(F)(F)F>>C=C(C)C(=O)OC(C(F)(F)F)C(F)(F)C(O)(C(F)(F)F)C(F)(F)F,,O,,CCN(CC)CC,Cc1ccccc1,val
US20120264706A1,CC(=O)OC(O)[C@H]1O[C@@H](N2CN=C3C2=NC(Cl)=NC3(N)Cl)[C@@](O)(OC(C)=O)[C@@]1(O)OC(C)=O.NC1CCCC1>>OC[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@H](O)[C@@H]1O,,CCOC(C)=O,O,CCO,,val
US20100322855A1,CC(C)(C)OC(=O)CN1CCN(CC(=O)[O-])CCN(CC(=O)[O-])CCN(CC(CCCc2ccc([N+](=O)[O-])cc2)N(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)CC1>>O=C(O)CN1CCN(CC(=O)O)CCN(CC(CCCc2ccc([N+](=O)[O-])cc2)N(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC1,,C1COCCO1,,CCOCC,Cl,val
US20040167123A1,CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(N)ccc3N2)c(O)c2cccnc21.COC(=O)CS(=O)(=O)Cl>>COC(=O)CS(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(c1c(O)c3cccnc3n(CCC(C)C)c1=O)N2,,ClCCl,,CCN(CC)CC,,val
US20100022550A1,CC(C)C(=O)Cl.NC1CCc2c(c3cc(OC(F)(F)F)ccc3n2Cc2cccc(F)n2)C1>>CC(C)C(=O)NC1CCc2c(c3cc(OC(F)(F)F)ccc3n2Cc2cccc(F)n2)C1,,ClCCl,,CCN(CC)CC,Cl,val
US06235778B1,Cc1cc(OCCCON)cc(OS(=O)(=O)c2ccccc2Cl)c1.N=C(N)n1cccn1>>Cc1cc(OCCCONC(=N)N)cc(OS(=O)(=O)c2ccccc2Cl)c1,,CN(C)C=O,,Cl,,val
US20140155477A1,Cc1cc(C(C)(C)C)cc(C)c1S(=O)(=O)Cl.Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>Cc1cc(C(C)(C)C)cc(C)c1S(=O)(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,c1ccncc1,,,,val
US20040097590A1,C=CCBr.CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccccc1>>C=CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)OCC)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140303142A1,CC(C)[C@H](Nc1cncc(-c2cn(COCC[Si](C)(C)C)c3ncc(N)cc23)c1)C(=O)NCC(F)(F)F.CS(=O)(=O)Cl>>CC(C)[C@H](Nc1cncc(-c2cn(COCC[Si](C)(C)C)c3ncc(NS(C)(=O)=O)cc23)c1)C(=O)NCC(F)(F)F,,ClCCl,c1ccncc1,,,val
US04125726,COC(=O)c1[nH]c(=S)n2c1CN=C(c1ccccc1Cl)c1cc(Cl)ccc1-2>>O=C(O)c1[nH]c(=S)n2c1CN=C(c1ccccc1Cl)c1cc(Cl)ccc1-2,,CO,,[K+].[OH-],,val
US20150038473A1,CCOC(=O)O[C@]1(C(=O)OCCl)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C>>CCOC(=O)O[C@]1(C(=O)OCCl)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C,,CC#N,O,,,val
US20020042421A1,COC(=O)C1=C(CCc2nccs2)NC(CC(=O)N2CCN(C3CC4CCC(C3)C4=O)CC2)=C(C(=O)OC)C1c1c(Cl)cccc1Cl>>COC(=O)C1=C(CCc2nccs2)NC(CC(=O)N2CCN(C3CC4CCC(C3)C4O)CC2)=C(C(=O)OC)C1c1c(Cl)cccc1Cl,,CO,,[BH4-].[Na+],,val
US20100068197A1,COc1ccc(N(C)c2nc(Cl)nc3ccc(OC)cc23)cc1.NCCNC(=O)OCc1ccccc1>>COc1ccc(N(C)c2nc(NCCNC(=O)OCc3ccccc3)nc3ccc(OC)cc23)cc1,,CCOC(C)=O,CN1CCCC1=O,CCN(CC)CC,,val
US04009175,CSc1ccc2c(c1)C(c1ccccn1)=NCC(=O)N2.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CSc1ccc2c(c1)C(c1ccccn1)=NCC(=S)N2,,c1ccncc1,,,,val
US20040229900A1,O=C(Nc1ccccc1)N1CC2CC(CN(Cc3ccccc3)C2)C1>>O=C(Nc1ccccc1)N1CC2CNCC(C2)C1,[Pd],CCO,,,,val
US20130295051A1,CSC(=NC#N)Nc1cccnc1.NCc1ccc(S(=O)(=O)c2ccccc2)cc1>>N#CN=C(NCc1ccc(S(=O)(=O)c2ccccc2)cc1)Nc1cccnc1,CN(C)c1ccncc1,c1ccncc1,,,,val
US20090197864A1,C[C@H](O)c1nnc2ccc(Cl)nn12.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>C[C@H](O)c1nnc2ccc(-c3cnn(C)c3)nn12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20080045521A1,COC(=O)[C@H](Cc1ccc(CCCc2ccc3c(n2)NCCC3)nc1)NC(=O)c1c(Cl)cccc1Cl>>O=C(N[C@@H](Cc1ccc(CCCc2ccc3c(n2)NCCC3)nc1)C(=O)O)c1c(Cl)cccc1Cl,,C1CCOC1,,[Na+].[OH-],,val
US20050250797A1,Cc1ccccc1S(=O)(=O)Cl.c1cn[nH]c1>>Cc1ccc(S(=O)(=O)n2cccn2)cc1,,c1ccncc1,,ClCCl,,val
US20160016951A1,CN.Cn1cc(-c2ccc(-c3cncc4ccc(Cl)nc34)cc2)cn1>>CNc1ccc2cncc(-c3ccc(-c4cnn(C)c4)cc3)c2n1,,CN1CCCC1=O,,CCN(CC)CC,Cl,val
US20100179150A1,CCOC(=O)c1sc(N2CC[C@H](NC(=O)c3[nH]c(C)c(Cl)c3Cl)[C@H](OC)C2)nc1CO>>CCOC(=O)c1sc(N2CC[C@H](NC(=O)c3[nH]c(C)c(Cl)c3Cl)[C@H](OC)C2)nc1C=O,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20160060273A1,CI.COC(=O)C1(O)CCN(C2=NOC3(C2)CN(C(=O)OC(C)(C)C)C3)CC1>>COC(=O)C1(OC)CCN(C2=NOC3(C2)CN(C(=O)OC(C)(C)C)C3)CC1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],[Cl-].[NH4+],val
US04732912,C#CCCCCOC1CCCCO1.COc1ccc(C2(C)CCc3cc(OC)ccc3C2=O)cc1>>COc1ccc(C2(C)CCc3cc(OC)ccc3C2(O)C#CCCCCOC2CCCCO2)cc1,,C1CCOC1,CCCCCC,[Li]CCCC,[Cl-].[NH4+],val
US04002751,CNN.O=c1c(Cl)c(Cl)cnn1-c1ccccc1>>CN(N)c1cnn(-c2ccccc2)c(=O)c1Cl,,CO,,O,,val
US20120329785A1,CN1CCCN(c2ccc(N)cc2)CC1.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccccc23)cc1>>CN1CCCN(c2ccc(Nc3nc4ccccc4c4c[nH]nc34)cc2)CC1,C1COCCO1,CO,,Cl,,val
US20080193878A1,CC(O)c1ccccc1.O=C(O)CC=Cc1ccccc1>>CC(OC(=O)CC=Cc1ccccc1)c1ccccc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060229326A1,O=C(O)c1cnc(Cl)c(Br)c1.OCc1ccccc1>>O=C(O)c1cnc(OCc2ccccc2)c(Br)c1,,CS(C)=O,,Cl,[K+].[OH-],val
US20160038504A1,Fc1ncc(Br)cc1N1CCOCC1.OC1CC2(COC2)C1>>Brc1cnc(OC2CC3(COC3)C2)c(N2CCOCC2)c1,,C1COCCO1,,O,[H-].[Na+],val
US20130072506A1,CC(C)=CCN.Nc1nc2c(Cl)ncnc2n1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O>>CC(C)=CCNc1ncnc2c1nc(N)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O,,CCCO,,Cl,,val
US06150379,N#Cc1ccc2[nH]c(-c3ccccn3)nc2c1.NO>>N=C(NO)c1ccc2[nH]c(-c3ccccn3)nc2c1,,CO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20020049323A1,CCCCCCNCCCCCC.CCOC(=O)c1c(O)c2ccccc2n(Cc2ccccc2)c1=O>>CCCCCCN(CCCCCC)C(=O)c1c(O)c2ccccc2n(Cc2ccccc2)c1=O,,ClC(Cl)Cl,,Cl,,val
US20120046271A1,CNC(=O)c1ccc(-c2ccc3c(c2)CN2CCC3(c3ccc(F)c(Cl)c3)CC2)nn1.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>CNC(=O)c1ccc(-c2ccc3c(c2)CN2CCC3(c3ccc(F)c(Cl)c3)CC2)nn1.O=C(O)[C@H](O)[C@@H](O)C(=O)O,,O,,CC#N,,val
US04942245,BrCCCCBr.CCCc1c(S)ccc(C(C)=O)c1O>>CCCc1c(SCCCCBr)ccc(C(C)=O)c1O,,CC(C)=O,,[I-].[K+],,val
US06232467B1,CC(C)C[C@H](N)C(=O)O.O=CC(=O)O.OB(O)/C=C/c1ccccc1>>CC(C)CC(N[C@@H](C=Cc1ccccc1)C(=O)O)C(=O)O,,O,,,,val
US20050282821A1,NC(=O)CSCc1cccc2oc3cc(Cl)ccc3c12.OO>>NC(=O)CS(=O)Cc1cccc2oc3cc(Cl)ccc3c12,,CC(=O)O,,,,val
US20110207728A1,CN(C)C(=O)c1cc(C(=O)O)n(CC(=O)c2ccc(Cl)cc2)c1.NCCN>>CN(C)C(=O)c1cc2n(c1)CC1(c3ccc(Cl)cc3)NCCN1C2=O,,C1COCCO1,,,,val
US04016280,O=C(c1ccccc1)C1CN(CCCO)CCC1(O)c1ccccc1>>OCCCN1CCC(c2ccccc2)(c2ccccc2)CC1,,c1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100093698A1,COc1cc(C(O)c2cccc3nc(Nc4ccc(C(F)(F)F)cc4)nn23)ccn1.O=S(Cl)Cl>>COc1cc(C(Cl)c2cccc3nc(Nc4ccc(C(F)(F)F)cc4)nn23)ccn1,,ClC(Cl)Cl,,,,val
US20010004669A1,CCC=O.O=C(Nc1ccc2cccc(N3CCNCC3)c2c1)c1ccc(Cl)cc1>>CCCN1CCN(c2cccc3ccc(NC(=O)c4ccc(Cl)cc4)cc23)CC1,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20090163715A1,CC1(C)C=C(OS(=O)(=O)C(F)(F)F)CC(C)(C)C1.OB(O)c1ccccc1Br>>CC1(C)C=C(c2ccccc2Br)CC(C)(C)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20100284970A1,C1CCNC1.ClCc1nc2ccccc2n1Cc1ccc(Cl)cc1>>Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1,,CC#N,,[I-].[K+],,val
US20130203746A1,CN1CCC(=O)CC1.COC(=O)c1ccc(NN)cc1.Clc1ccc(CCBr)cc1>>CN1CCc2[nH]c3ccc(C(=O)O)cc3c2C1CCc1ccc(Cl)cc1,,CCN(CC)CC,,,,val
US20150166563A1,COC(=O)CC12CCC(c3ccc(B4OC(C)(C)C(C)(C)O4)cc3)(CC1)CO2.O=[N+]([O-])c1ccc(I)cc1>>COC(=O)CC12CCC(c3ccc(-c4ccc([N+](=O)[O-])cc4)cc3)(CC1)CO2,,COCCOC,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20080194833A1,COc1ccc(OCCCN)cc1.O=Cc1cccc(O)c1>>COc1ccc(OCCCNCc2cccc(O)c2)cc1,,CO,,O,[BH4-].[Na+],val
US20110178063A1,CCn1ncc(Cl)c1C(=O)Cl.C[Sn](C)(C)c1cc(N)c2cnn(S(=O)(=O)c3ccccc3)c2c1>>CCn1ncc(Cl)c1C(=O)Nc1cc([Sn](C)(C)C)cc2c1cnn2S(=O)(=O)c1ccccc1,,ClCCl,c1ccncc1,O=C([O-])O.[Na+],,val
US20060167012A1,C[C@H]1CNCCN1.FC(F)(F)c1ccc(Br)nc1>>C[C@H]1CN(c2ccc(C(F)(F)F)cn2)CCN1,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,,val
US20110212053A1,CCOC(=O)CC(=O)OCC.O=[N+]([O-])c1cnc2ccc(Br)cc2c1Cl>>CCOC(=O)C(C(=O)OCC)c1c([N+](=O)[O-])cnc2ccc(Br)cc12,,CN(C)C=O,,[H-].[Na+],,val
US20150344473A1,CC1(C)OB(c2ccc(OC3CCOCC3)c(C#N)c2)OC1(C)C.Cc1ncc(-c2nc3c(Cl)ncnc3[nH]2)s1>>Cc1ncc(-c2nc3c(-c4ccc(OC5CCOCC5)c(C#N)c4)ncnc3[nH]2)s1,,O,,C1COCCO1,O=C([O-])[O-].[Cs+].[Cs+],val
US20150299198A1,Cc1c([C@@H]2CO2)ccc2c1COC2=O.O=C1c2ccc(-n3cnnn3)cc2CN1C1CCNCC1>>Cc1c([C@@H](O)CN2CCC(N3Cc4cc(-n5cnnn5)ccc4C3=O)CC2)ccc2c1COC2=O,,CCO,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US04544657,COc1ccc(Cc2ncc(C(=O)O)c3cc(OC)c(OC)cc23)cc1OC>>COc1ccc(Cc2ncc(CO)c3cc(OC)c(OC)cc23)cc1OC,,O,,C1CCOC1,,val
US05336778,N#Cc1ccccc1-c1ccc(CN=[N+]=[N-])cc1.NN.S=C=S>>N#Cc1ccccc1-c1ccc(CNC(=S)NN)cc1,,O,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100305128A1,Cc1cccc(Nc2nccc(-c3ccc(NC(=O)OC(C)(C)C)s3)n2)c1.Cl>>Cc1cccc(Nc2nccc(-c3ccc(N)s3)n2)c1.Cl,,C1COCCO1,ClCCl,O=C(O)C(F)(F)F,,val
US20070207995A1,Brc1cccc(Br)n1.CC(C)(C)OC(=O)N1CCC(=O)CC1>>CC(C)(C)OC(=O)N1CCC(O)(c2cccc(Br)n2)CC1,,ClCCl,,[Li]CCCC,[Cl-].[NH4+],val
US04064258,CCS(=O)(=O)c1ncc(C(=O)NCCC23CC4CC(CC(C4)C2)C3)s1.OCC1CO1>>O=C(NCCC12CC3CC(CC(C3)C1)C2)c1cnc(OCC2CO2)s1,,C1CCOC1,,[H-].[Na+],,val
US20090314990A1,COc1cc(N(c2ccc(C=O)cc2)c2ccc(C=O)cc2)ccc1C=O>>O=Cc1ccc(N(c2ccc(C=O)cc2)c2ccc(C=O)c(O)c2)cc1,,ClCCl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20140155421A1,CC(=O)Cl.Cc1ccc(Cl)cc1-c1[nH]ccc1C#N>>CC(=O)c1cc(C#N)c(-c2cc(Cl)ccc2C)[nH]1,,ClCCl,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20070117854A1,BrBr.CC(C)(C)c1cc[nH]n1>>CC(C)(C)c1n[nH]cc1Br,,O,,[Na+].[OH-],,val
US20060217372A1,NC(=O)c1ccc(Oc2ccc3c(c2)CNCC3)nc1.O=Cc1ccccc1>>NC(=O)c1ccc(Oc2ccc3c(c2)CN(Cc2ccccc2)CC3)nc1,,ClCCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US05246951,ClCCBr.O=[Se]1C=Nc2ccccc21>>O=[Se]1CN(CCCl)c2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150038481A1,CCCCNc1ncc(-c2ccc(C=O)o2)c(N[C@@H]2CC[C@@H](O)CC2)n1.CN1CCNCC1>>CCCCNc1ncc(-c2ccc(CN3CCN(C)CC3)o2)c(N[C@@H]2CC[C@@H](O)CC2)n1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150065482A1,CC(C)OB(OC(C)C)OC(C)C.Fc1cc(Br)cc(Br)c1>>OB(O)c1cc(F)cc(Br)c1,,C1CCOC1,,[Li]CCCC,,val
US04696943,CC[C@H](N)C(N)=O.O=C(Cl)CCCCl>>CC[C@H](NC(=O)CCCCl)C(N)=O,,CC#N,CCOCC,Cl,O=C([O-])[O-].[K+].[K+],val
US04962234,CC(=O)c1ccccc1.CCCCCCCCCCCCc1ccc(N)cc1>>CCCCCCCCCCCCc1ccc(N=C(C)c2ccccc2)cc1,,O,,c1ccccc1,,val
US04267381,CC(C)(CF)C(=O)C(Br)Oc1ccc(Cl)cc1.c1nc[nH]n1>>CC(C)(CF)C(=O)C(Oc1ccc(Cl)cc1)n1cncn1,,CC(C)=O,,,,val
US20090176778A1,C#Cc1cc(C(F)(F)F)c2nc(C(=O)NCc3cccs3)c(Cl)n2c1.C[Si](C)(C)N=[N+]=[N-]>>O=C(NCc1cccs1)c1nc2c(C(F)(F)F)cc(-c3cn[nH]n3)cn2c1Cl,[Cu]I,CN(C)C=O,CO,,,val
US04670448,Cn1nc(C=NO)nc1NCCCOc1cccc(CN2CCCCC2)c1>>Cn1nc(C#N)nc1NCCCOc1cccc(CN2CCCCC2)c1,,CC(=O)OC(C)=O,,O=C([O-])O.[Na+],,val
US20160168096A1,CC(C)(C)S.Clc1cccc(Cl)n1>>CC(C)(C)Sc1cccc(Cl)n1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05519015,CCOC(=O)c1sc(C(=O)OC(C)(C)C)cc1OC(C)(C)C>>CC(C)(C)OC(=O)c1cc(OC(C)(C)C)c(C(=O)O)s1,,C1COCCO1,,Cl,[Na+].[OH-],val
US06300363B1,CC(CC(=O)Nc1c(C(=O)c2ccccc2)[nH]c2cc(Cl)ccc12)OCc1ccccc1>>CC(O)CC(=O)Nc1c(C(=O)c2ccccc2)[nH]c2cc(Cl)ccc12,[Pd],CCOC(C)=O,,,,val
US20120208798A1,CC(=O)N1c2ccc(Br)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.CC1(C)OB(c2ccc(C#N)cc2)OC1(C)C>>CC(=O)N1c2ccc(-c3ccc(C#N)cc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[K+].[K+],val
US20100197697A1,CCOC(=O)C1=C(c2ccc(F)c(F)c2)CN(Cc2ccccc2)CC1>>CCOC(=O)C1CCNCC1c1ccc(F)c(F)c1,[Pd],CCO,,,,val
US20080076758A1,C[C@H]1CN(S(C)(=O)=O)C[C@@H](C)N1.Clc1nc(N2CCOCC2)c2sc(CBr)cc2n1>>C[C@H]1CN(S(C)(=O)=O)C[C@@H](C)N1Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04364948,CC(O)CCN.CCOC(=O)c1c(C)nc2c(cnn2CC)c1Cl>>CCOC(=O)c1c(C)nc2c(cnn2CC)c1NCCC(C)O,,Cc1ccccc1,,,,val
US20050272794A1,CCOC(=O)c1ccc([C@H](C)n2nc(-c3cc(Cl)cc(Cl)c3)cc2OS(=O)(=O)C(F)(F)F)cc1.COc1ccc2cc(B(O)O)ccc2c1>>CCOC(=O)c1ccc([C@H](C)n2nc(-c3cc(Cl)cc(Cl)c3)cc2-c2ccc3cc(OC)ccc3c2)cc1,,COCCOC,,CCN(CC)CC,,val
US20060148858A1,CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCCO.COC(=O)Cc1cccc(OC)c1O>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCCOc1c(CC(=O)O)cccc1OC,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20020161021A1,CC(=O)OC(C)(C)C.CCOC(=O)CC(O)CC#N>>CC(C)(C)OC(=O)CC(=O)CC(O)CC#N,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20160022626A1,C[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccccc1CCC(=O)O.O=C(O)C(F)(F)F>>C[C@H](N)C(=O)Nc1ccccc1CCC(=O)O.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20110098324A1,CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(Cc2ccc(C(F)(F)F)cc2F)c1=O.COc1cc(CN)ccc1O>>COc1cc(CNC(=O)c2c(O)c(C(=O)NCC(=O)O)c(=O)n(Cc3ccc(C(F)(F)F)cc3F)c2O)ccc1O,,C1COCCO1,CCOC(C)=O,[Na+].[OH-],,val
US20030114468A1,NCc1ccccc1.Nc1c(Cl)ncnc1Cl>>Nc1c(Cl)ncnc1NCc1ccccc1,,CCO,,CCN(CC)CC,,val
US05650510,CCOP([O-])OCC.ClCOCCCCBr>>CCOP(=O)(COCCCCBr)OCC,,CCCCC,,[H-].[Na+],,val
US06586441B2,CCCN.CSc1nc(N)nc(-c2ccco2)c1C#N>>CCCNc1nc(N)nc(-c2ccco2)c1C#N,,CCO,,,,val
US05114918,CSCC[C@@H]1NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2cn(C=O)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C(C)C)NC1=O.OO>>CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@H](CCS(C)=O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2cn(C=O)c3ccccc23)NC1=O,,CC(=O)O,,,,val
US20150232450A1,CCc1cncc(Nc2cc(COc3ccc(NC(=O)OC(C)(C)C)c4ccccc34)ccn2)n1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Oc2ccccc2)cc1>>CCc1cncc(Nc2cc(COc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(C)cc4)c4ccccc34)ccn2)n1,,C1CCOC1,,CCN(CC)CC,,val
US20140349972A1,Brc1ccc(Br)cc1.CC(C)(C)[S@](=O)/N=C/c1ccc(F)cc1F>>CC(C)(C)[S@](=O)N[C@@H](c1ccc(Br)cc1)c1ccc(F)cc1F,,C1CCOC1,,[Li]CCCC,,val
US20140309213A1,C[C@H]1Cc2cc(C3CO3)ccc2C(=O)O1.Cc1c([C@@H](O)CN2[C@H]3CC[C@@H]2CNC3)ccc2c1COC2=O>>Cc1c([C@@H](O)CN2CCN(CC(O)c3ccc4c(c3)C[C@@H](C)OC4=O)CC2)ccc2c1COC2=O,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20050113399A1,CC(C)(C)OC(=O)Nc1cc2ccn(-c3ccc([N+](=O)[O-])cc3)c(=O)c2cc1F.CI>>CN(C(=O)OC(C)(C)C)c1cc2ccn(-c3ccc([N+](=O)[O-])cc3)c(=O)c2cc1F,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20160221972A1,COC(=O)c1ccc2c(c1)O[C@H](c1ccccc1)CN(C(=O)Nc1ccc(OC)cc1)C2.NO>>COc1ccc(NC(=O)N2Cc3ccc(C(=O)NO)cc3O[C@H](c3ccccc3)C2)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20160002264A1,C=CCC(CC1CC1)OCC=O.NO>>C=CCC(CC1CC1)OC/C=N/O,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20040077877A1,CN(C)CC(=O)NN.CO.N#Cc1ccc2c(c1)c(-c1cc3ccccc3o1)nn2C1CCCCO1>>CN(C)Cc1n[nH]c(-c2ccc3c(cnn3C3OCCCC3c3cc4ccccc4o3)c2)n1,,CO,ClCCl,C[O-].[Na+],,val
US20150119393A1,CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@H](Oc3nc4cc(Cl)c(-c5ccc([C@@H]6CC[C@@H](O)CC6)cc5)nc4n3COCC[Si](C)(C)C)CO[C@H]12.O=C(Cl)N1CCOCC1>>CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@H](Oc3nc4cc(Cl)c(-c5ccc([C@@H]6CC[C@@H](OC(=O)N7CCOCC7)CC6)cc5)nc4n3COCC[Si](C)(C)C)CO[C@H]12,,c1ccncc1,,,,val
US20130210796A1,C[C@@H]1NCCNC1=O.FC(F)(F)c1ccc(-n2nnnc2CCl)cc1>>C[C@H]1C(=O)NCCN1Cc1nnnn1-c1ccc(C(F)(F)F)cc1,,CC#N,,CCN(CC)CC,,val
US20060089350A1,CCNCC.NS(=O)(=O)c1cc(C(=O)O)cc(N2CCCC2)c1Oc1ccccc1>>CCN(CC)C(=O)c1cc(N2CCCC2)c(Oc2ccccc2)c(S(N)(=O)=O)c1,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US05935756,CCCCOc1ccc(OCCCC)c(OC(C)=O)c1>>CCCCOc1ccc(OCCCC)c(O)c1,,O,,CCO,[K+].[OH-],val
US20030187268A1,CC(=O)NCc1cn(-c2ccc(Cl)c(Cl)c2)cn1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(=S)NCc1cn(-c2ccc(Cl)c(Cl)c2)cn1,,COCCOC,,ClCCl,O=C([O-])O.[Na+],val
US20090214675A1,C/C(N)=C/C(=O)OC(C)C.CC([O-])=CC#N.Cc1cc(=O)c2c(F)c(F)cc(C=O)c2o1>>CC1=C(C#N)C(c2cc(F)c(F)c3c(=O)cc(C)oc23)C(C(=O)OC(C)C)=C(C)N1,,CC(C)O,,CC(=O)O,,val
US20120277224A1,CCOC(=O)CC(=O)c1ccc(F)cc1F.Nc1[nH]ncc1-c1ccccn1>>O=c1cc(-c2ccc(F)cc2F)[nH]c2c(-c3ccccn3)cnn12,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20140088078A1,CC(C)(C)OC(=O)N1CC[C@H](NC(=O)OCc2ccccc2)C1.CI>>CN(C(=O)OCc1ccccc1)[C@H]1CCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,CO,[H-].[Na+],val
US04144338,CN(C)CCN.COc1ccncn1>>CN(C)CCNc1ccncn1,,Cc1ccccc1C,,,,val
US09056859B2,CC(C)(C)OC(=O)N1CCN(C(=O)Cc2cccc(-n3cnnn3)c2)CC1>>CC(C)(C)OC(=O)N1CCN(CCc2cccc(-n3cnnn3)c2)CC1,,C1CCOC1,,Cl,[Na+].[OH-],val
US05216003,CCO.CCOP(=O)(Cc1cccc(N)c1[N+](=O)[O-])OCC>>O=P(O)(O)Cc1cccc2nc(CO)[nH]c12,[Pd],,,Cl,,val
US06156758,COC(=O)c1nc(Cl)c(NC2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)CC2)nc1N>>COc1cc2nc(N3CCC(Nc4nc(N)c(C(=O)O)nc4Cl)CC3)nc(N)c2cc1OC,,CCO,,[K+].[OH-],,val
US05157041,CC(C)(C)OC(=O)[C@@H]1CCCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(N)=O.O=C(Cl)Cc1ccccc1>>CC(C)(C)OC(=O)[C@@H]1CCCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccccc1,,CCCCCC,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20120059028A1,CCCC(C(=O)OC)c1c(C)nc2sc3c(c2c1-c1ccc(CC)cc1)CCC3>>CCCC(C(=O)O)c1c(C)nc2sc3c(c2c1-c1ccc(CC)cc1)CCC3,,CCO,CO,[Na+].[OH-],,val
US20150203472A1,Cc1ccc(-n2cnc3ccc(Br)cc32)cc1.Cc1ccc(-n2nccc2B(O)O)cc1>>Cc1ccc(-n2nccc2-c2ccc3ncn(-c4ccc(C)cc4)c3c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US05130301,CN.O=C1NC(O)c2cccn2-c2ccsc21>>CNC1NC(=O)c2sccc2-n2cccc21,,O,,,,val
US05968965,COC(=O)C=Cc1c[nH]cn1>>COC(=O)CCc1c[nH]cn1,[Pd],CO,,[H][H],,val
US20160024093A1,CC(C)CCBr.O=C1CC[C@@H](CN2C(=O)c3ccccc3C2=O)N1>>CC(C)CCN1C(=O)CC[C@H]1CN1C(=O)c2ccccc2C1=O,,CCOC(C)=O,CS(C)=O,[H-].[Na+],,val
US20150284327A1,COC(=O)Cc1ccc(C(=O)OC)cc1[N+](=O)[O-]>>COC(=O)c1ccc2c(c1)NC(=O)C2,[Pd],CC(=O)O,,,,val
US20050137226A1,CC(C)(C)OC(=O)NN.Ic1ccc(Oc2ccc(OC3CN4CCC3CC4)cc2)cc1>>CC(C)(C)OC(=O)N(N)c1ccc(Oc2ccc(OC3CN4CCC3CC4)cc2)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080058521A1,COc1ccc(-c2ccc(CS(C)(=O)=O)cc2)cc1CN(C(=O)c1sc2c(F)ccc(F)c2c1Cl)C1CCC(N(C)C(=O)OC(C)(C)C)CC1.Cl>>CNC1CCC(N(Cc2cc(-c3ccc(CS(C)(=O)=O)cc3)ccc2OC)C(=O)c2sc3c(F)ccc(F)c3c2Cl)CC1.Cl,,ClCCl,,COC(C)(C)C,,val
US20120202785A1,CC(N)c1sc2ccccc2c1-c1ccccc1.Clc1ncnc2[nH]cnc12>>CC(Nc1ncnc2[nH]cnc12)c1sc2ccccc2c1-c1ccccc1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20030105098A1,CC(C)n1cnc2c(Cl)nc(Cl)nc21.COc1ccc(CN)cc1>>COc1ccc(CNc2nc(Cl)nc3c2ncn3C(C)C)cc1,,CCN(CC)CC,,,,val
US20160235716A1,C[C@@H](C1CCC1)N(Cc1ccc(Br)cc1)S(=O)C(C)(C)C.Cl>>C[C@H](NCc1ccc(Br)cc1)C1CCC1.Cl,,CO,,,,val
US20100130495A1,CCC(=O)Cl.OCCN(c1ccccc1)c1nc(Nc2ccc(-c3cnco3)cc2)nc2c1CNCC2>>CCC(=O)N1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(N(CCO)c3ccccc3)c2C1,,CN(C)C=O,ClCCl,CCN(CC)CC,,val
US20090197863A1,CN.COC(=O)c1cccc2nc(-c3ccc(CBr)cc3)oc12>>CNCc1ccc(-c2nc3cccc(C(=O)OC)c3o2)cc1,,CO,,,,val
US20090176996A1,BrCc1csc2ccccc12.CC(C)(C)OC(=O)NS(N)(=O)=O>>CC(C)(C)OC(=O)N(Cc1csc2ccccc12)S(N)(=O)=O,,CCCCCCC,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04721791,CI.NC(=O)c1nnn(Cc2ccc(Cl)c(Cl)c2)c1N>>CNc1c(C(N)=O)nnn1Cc1ccc(Cl)c(Cl)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100130495A1,Cc1nccn1-c1ccc(Nc2nc3c(c(OS(=O)(=O)C(F)(F)F)n2)CN(C)CC3)cc1.OC[C@@H]1Cc2ccccc2N1>>Cc1nccn1-c1ccc(Nc2nc3c(c(N4c5ccccc5C[C@H]4CO)n2)CN(C)CC3)cc1,,CS(C)=O,,,,val
US20050250798A1,CC(Br)CCBr.O=C1Nc2ccc(S(=O)(=O)N3CCCC3)cc2C12OCCCO2>>CC(Br)C(C)N1C(=O)C2(OCCCO2)c2cc(S(=O)(=O)N3CCCC3)ccc21,,CS(C)=O,,O,CC(C)(C)[O-].[K+],val
US03998958,CCOC(=O)c1ccc(OCc2ccccc2)c(Cl)c1.NN>>NNC(=O)c1ccc(OCc2ccccc2)c(Cl)c1,,CO,,,,val
US20040171881A1,CCc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1.CS(=O)(=O)Cc1ccc(C(=O)O)cn1>>CCc1cccc(CNC[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2ccc(CS(C)(=O)=O)nc2)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080146569A1,NC1CCN(c2ncccn2)CC1.O=C(O)c1ccc(-c2ccccc2O)nc1>>O=C(NC1CCN(c2ncccn2)CC1)c1ccc(-c2ccccc2O)nc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080108689A1,CC(C)=O.Cc1cc(F)ccc1[C@@H]1[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC[C@@H]2CNC[C@H]21>>Cc1cc(F)ccc1[C@@H]1[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC[C@@H]2CN(C(C)C)C[C@H]21,CC(=O)O,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20020028823A1,BrCc1ccccc1.Cc1nc2c([nH]1)c(=O)[nH]c(=O)n2C>>Cc1nc2c(c(=O)[nH]c(=O)n2C)n1Cc1ccccc1,,CO,O,[Na+].[OH-],,val
US20080132494A1,COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)cc([N+](=O)[O-])c1.Cc1ccc(Br)nc1>>COC(=O)c1cc(-c2ccc(C)cn2)cc([N+](=O)[O-])c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US05354913,CC(=O)OC(C)=O.OCC[C@H](O)c1ccccc1>>CC(=O)OCC[C@H](O)c1ccccc1,,ClCCl,,c1ccncc1,,val
US20040044052A1,CN.COC(=O)[C@H]1CN(c2cc(F)c3c(c2)CCC(=O)N3C)C(=O)O1>>CNC(=O)[C@H]1CN(c2cc(F)c3c(c2)CCC(=O)N3C)C(=O)O1,,CO,,,,val
US06093716,CC(C)(C)OC(=O)N1CCN(c2ccc(-c3ccnc(Cl)n3)cn2)CC1.O=C(Cl)OCc1ccccc1>>O=C(OCc1ccccc1)N1CCN(c2ccc(-c3ccnc(Cl)n3)cn2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160206748A1,CC1(CO)CC=CC1.CCCCCCCCCCCCBr>>CCCCCCCCCCCCOCC1(C)CC=CC1,,C1CCOC1,,[H-].[Na+],,val
US20110009454A1,COc1ccccc1Oc1cccc(CN)c1.Cc1ccc(C(=O)O)c(N)n1>>COc1ccccc1Oc1cccc(CNC(=O)c2ccc(C)nc2N)c1,,CN(C)C=O,O,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20090275037A1,COc1ccc2c(c1)c(=O)oc(=O)n2C.N>>CNc1ccc(OC)cc1C(N)=O,,C1CCOC1,,,,val
US20150175594A1,Cc1csc(-c2c(NC(=O)C3=C(C(=O)O)CCC3)sc3c2CCC(F)(F)C3)n1.O=C1OC(=O)C2=C1C1CCC2CC1>>Cc1csc(-c2c(NC(=O)C3=C(C(=O)O)C4CCC3CC4)sc3c2CCC(F)(F)C3)n1,,C1CCOC1,,,,val
US20120190678A1,CC(C)(C)OC(=O)N1CCC(Cn2nc(C(N)=O)c3c2-c2nc(I)ncc2CC3)CC1.OB(O)c1c(F)cccc1F>>CC(C)(C)OC(=O)N1CCC(Cn2nc(C(N)=O)c3c2-c2nc(-c4c(F)cccc4F)ncc2CC3)CC1,,C1COCCO1,O,ClCCl,O=C([O-])[O-].[Cs+].[Cs+],val
US20100076027A1,COc1cccc(CC(=O)Cl)c1.c1ccc(-n2nc3ccccc3c2NC2CCCCC2)cc1>>COc1cccc(C(C(=O)NC2CCCCC2)c2c3ccccc3nn2-c2ccccc2)c1,,CCN(CC)CC,,,,val
US20080207654A1,C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CCCc1nc(C)n(O)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O>>CCCc1nc(C)n(OC2C[C@H](C)O[C@H](C)C2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120232063A1,C#C[Si](C)(C)C.Nc1ccc(I)cc1C(=O)O>>C[Si](C)(C)C#Cc1ccc(N)c(C(=O)O)c1,I[Cu]I,,,CCN(CC)CC,,val
US20030069284A1,O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.c1ccncc1>>NC(=O)Oc1ccc([N+](=O)[O-])cc1,,ClCCl,,,,val
US20060258740A1,CCOC(=O)C=Cc1ccccc1-c1cccc(C)c1C>>Cc1cccc(-c2ccccc2C=CC(=O)O)c1C,,C1CCOC1,,[Na+].[OH-],,val
US20040082812A1,CC(=O)OCC(COC(C)=O)NC(=O)c1c(I)c(NC(=O)[C@H](C)OC(C)=O)c(I)c(C(=O)NC(COC(C)=O)COC(C)=O)c1I>>C[C@H](O)C(=O)Nc1c(I)c(C(=O)NC(CO)CO)c(I)c(C(=O)NC(CO)CO)c1I,,CO,,O,[Na+].[OH-],val
US20160159752A1,COC(=O)ON1C(=O)CCC1=O.C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H](CCc2c(F)cccc2NC(=O)[C@@H](N)[C@@H](c2ccc(Cl)cc2)C2CCOCC2)N1S(=O)(=O)c1ccc(F)cc1>>COC(=O)N[C@H](C(=O)Nc1cccc(F)c1CC[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H](C)N1S(=O)(=O)c1ccc(F)cc1)[C@@H](c1ccc(Cl)cc1)C1CCOCC1,,ClCCl,,,,val
US20100152445A1,Nc1ccc(N2CCC(c3cccc(C(F)(F)F)c3)CC2)nc1.O=C(Cl)c1nc(-c2ccccc2)oc1C(F)(F)F>>O=C(Nc1ccc(N2CCC(c3cccc(C(F)(F)F)c3)CC2)nc1)c1nc(-c2ccccc2)oc1C(F)(F)F,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US05698575,S=c1c(Br)coc2ccccc12.c1cc[nH]c1>>S=c1cc(-c2ccc[nH]2)oc2ccccc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140256710A1,CN1C=CC(N)=c2ccc3c4c([nH]c(=O)c-4c21)=CCN3c1ccc(F)cc1.O=C(O)CCN1CCCCC1>>CN1C=CC(NC(=O)CCN2CCCCC2)=c2ccc3c4c([nH]c(=O)c-4c21)=CCN3c1ccc(F)cc1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020035258A1,CON=C1CNCC12CN(C(=O)OC(C)(C)C)C2.O=C(O)c1cn(-c2ccc(F)cc2F)c2cc(F)c(F)cc2c1=O>>CON=C1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccc(F)cc2F)CC12CN(C(=O)OC(C)(C)C)C2,,CCN(CC)CC,,CC#N,,val
US20140051679A1,CCOC(=O)C(c1ccsc1)C1CCCC1>>O=C(O)C(c1ccsc1)C1CCCC1,,CO,,[Na+].[OH-],,val
US20030171380A1,CCC(CC)n1cc(Br)nc(SC)c1=O.C[Al](C)C>>CCC(CC)n1cc(C)nc(SC)c1=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,,,val
US20150023913A1,O=C(O)C1(COCc2ccccc2)CCCO1>>O=C(O)C1(CO)CCCO1,[Pd],CO,,N#N,,val
US20050148602A1,CS(=O)(=O)Cl.O=C1N(c2cc(Cl)cc(Cl)c2)C(=O)C2(Cc3ccc(Br)cc3)CNCCN12>>CS(=O)(=O)N1CCN2C(=O)N(c3cc(Cl)cc(Cl)c3)C(=O)C2(Cc2ccc(Br)cc2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06313136B1,CCc1cccc(C)c1CNc1cc(C(=O)O)cn2c(C)c(C)nc12.NC(=O)[C@@H]1CCCN1>>CCc1cccc(C)c1CNc1cc(C(=O)N2CCC[C@H]2C(N)=O)cn2c(C)c(C)nc12,,ClCCl,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20160038504A1,CCOC(=O)c1cc(C(C)(C)F)ccn1>>CC(C)(F)c1ccnc(C(=O)O)c1,,C1CCOC1,,[Li+].[OH-],,val
US20150119362A1,CN(C)C(=O)Cc1ccc(N)cc1.Cl.Clc1cccc(-c2cc(Cl)c3c(n2)CCC3)c1>>CN(C)C(=O)Cc1ccc(Nc2cc(-c3cccc(Cl)c3)nc3c2CCC3)cc1.Cl,,Cc1ccccc1,,,,val
US20040006065A1,CC(C)(C)OC(=O)NC(=N)c1ccc(CNC(=O)C2CCc3ncc(NC(=O)OCc4ccccc4)c(=O)n32)cc1>>CC(C)(C)OC(=O)NC(=N)c1ccc(CNC(=O)[C@@H]2CCc3ncc(N)c(=O)n32)cc1,[Pd],CO,,,,val
US20100120778A1,COc1cccc(C(=O)C(C)=O)c1.Nc1cccc(C(F)(F)F)c1N>>COc1cccc(-c2nc3cccc(C(F)(F)F)c3nc2C)c1,,CC(C)O,,,,val
US20080221114A1,COS(=O)(=O)OC.O=C(O)[C@@H]1Cc2ccccc2N1c1ccc(Cl)nn1>>Cn1nc(N2c3ccccc3C[C@H]2C(=O)O)ccc1=O,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20060079533A1,OC1(c2ccc(CCOC3CCCCO3)cc2)CCN(Cc2ccccc2)CC1>>OCCc1ccc(C2(O)CCN(Cc3ccccc3)CC2)cc1,,CO,,Cl,O=C([O-])O.[Na+],val
US20100305321A1,O=C(Nc1ccn(C2CO[C@H](COC(=O)c3ccccc3)S2)c(=O)n1)c1ccccc1>>O=C(Nc1ccn([C@@H]2CO[C@H](COC(=O)c3ccccc3)S2)c(=O)n1)c1ccccc1,,CO,,,,val
US20160009726A1,C[C@H]1CN(c2ccncc2N)C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C.O=C(O)c1ccc2ccn(C3CCC3)c2n1>>C[C@H]1CN(c2ccncc2NC(=O)c2ccc3ccn(C4CCC4)c3n2)C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05661108,C=CCBr.Cn1c(C(F)(F)F)cc(=O)n(-c2ccc3nc(C(F)(F)F)[nH]c3c2)c1=O>>C=CCn1c(C(F)(F)F)nc2ccc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)cc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US03997535,COc1ccc2nc(C(=O)O)c(=O)n(C)c2c1.Nc1nnn[nH]1>>COc1ccc2nc(C(=O)Nc3nnn[nH]3)c(=O)n(C)c2c1,,C1CCOC1,CN(C)C=O,,,val
US20070207994A1,Cn1nccc1-c1cc(N)ccc1OCCN1CCCCC1.O=C=Nc1ccccc1F>>Cn1nccc1-c1cc(NC(=O)Nc2ccccc2F)ccc1OCCN1CCCCC1,,ClCCl,,,,val
US20130102611A1,C=CCC(=O)OC.C=CCCCN1CCCc2nc(-c3ccccc3)c(-c3ccccc3)nc21>>O=C(O)C/C=C/CCCN1CCCc2nc(-c3ccccc3)c(-c3ccccc3)nc21,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,ClCCl,,,,val
US20060025347A1,CC(C)(C)OC(=O)N[C@@H](CCCN)C(=O)O.CCOC(=O)CCc1oc2ccccc2c1CC1CCCN1.CCOCC.CN1CCCC1=O.CN1CCOCC1>>CCOC(=O)CCc1oc2ccccc2c1CC1CCCN1C(=O)C(CCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C,,CCOCC,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20120252817A1,CC(C)(C)OC(=O)NC1(c2ncc(Br)cn2)CC1.Cl.ClCCl>>Cl.Cl.NC1(c2ncc(Br)cn2)CC1,,ClCCl,,C1COCCO1,,val
US20090270351A1,CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(C2CCP(C)(=O)O2)cc1>>CP1(=O)CCC(c2ccc(C(=O)Nc3cc(-c4cccs4)ccc3N)cc2)O1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20030166628A1,CC1=C(c2cccc3sccc23)N2CCN=C2S1.ClCCl>>CC1=C(c2cccc3sccc23)N2CCN=C2S1.Cl,,O,,Br,O=C([O-])O.[Na+],val
US04607031,Cc1ccc(C(=S)Nc2cc(F)ccc2F)cc1>>Cc1ccc(-c2nc3cc(F)ccc3s2)cc1,,CN(C)C=O,,O,CC(C)(C)[O-].[K+],val
US20040147748A1,BrC(Br)(Br)Br.CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2cnc(CO)cn2)cc1Cl>>CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2cnc(CBr)cn2)cc1Cl,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20060089375A1,CCOC(=O)c1cnc2c(cnn2CC)c1NC1CCCOC1>>CCn1ncc2c(NC3CCCOC3)c(C(=O)O)cnc21,,CCO,O,Cl,[Na+].[OH-],val
US05382593,CC(C)(C)OCl.CONC(=O)Cc1ccccc1>>CON(Cl)C(=O)Cc1ccccc1,,ClC(Cl)Cl,,,,val
US04180394,CC(C)N.CC(C)O.O=C(CN(CP(=O)(OCl)OCl)C(=O)C(F)(F)F)OCCCl>>CC(C)NOP(=O)(O)C(C(C)C)N(CC(=O)OCCCl)C(=O)C(F)(F)F,,C1CCOC1,CCOCC,CCN(CC)CC,,val
US04550105,C=CCO/N=C(\C(=O)Cl)c1csc(NC(=O)CCl)n1.COC(=O)[C@H]1NC(=O)[C@H]1N>>C=CCON=C(C(=O)N[C@@H]1C(=O)N[C@@H]1C(=O)OC)c1csc(NC(=O)CCl)n1,,C1CCOC1,O,Cl,O=C([O-])O.[Na+],val
US20110034450A1,CC(C)(C)OC(=O)C(c1ccc(CBr)cc1)C1CCCC1.O=c1[nH]nc(-c2ccc(Cl)cc2)c2ccccc12>>CC(C)(C)OC(=O)C(c1ccc(Cn2nc(-c3ccc(Cl)cc3)c3ccccc3c2=O)cc1)C1CCCC1,,C1CCOC1,CN(C)C=O,O,[H-].[Na+],val
US08785589B1,CC(=O)Nc1ccc(N=Nc2ccc(Oc3ccc(C(C)(c4ccc(Oc5ccc(N=Nc6ccc(NC(C)=O)cc6)cc5)cc4)c4ccc(Oc5ccc(N=Nc6ccc(NC(C)=O)cc6)cc5)cc4)cc3)cc2)cc1>>CC(c1ccc(Oc2ccc(N=Nc3ccc(N)cc3)cc2)cc1)(c1ccc(Oc2ccc(N=Nc3ccc(N)cc3)cc2)cc1)c1ccc(Oc2ccc(N=Nc3ccc(N)cc3)cc2)cc1,,O,,CCO,Cl,val
US20150087873A1,ClP(Cl)c1ccccc1.Fc1cccc2cccc([Mg]Br)c12>>Fc1cccc2cccc(Pc3ccccc3)c12.[Cl-],,C1CCOC1,,,,val
US20050107362A1,NC1c2ccccc2CC1NC(=O)c1cc2cc(Cl)ccc2[nH]1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C(NC1Cc2ccccc2C1NS(=O)(=O)C(F)(F)F)c1cc2cc(Cl)ccc2[nH]1,,ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20060205715A1,NC(=O)c1ccc(Oc2ccc3c(c2)CCC3=O)nc1.NCCc1cccc(Cl)c1>>NC(=O)c1ccc(Oc2ccc3c(c2)CCC3NCCc2cccc(Cl)c2)nc1,Cl[Ti](Cl)(Cl)Cl,,,[BH3-]C#N.[Na+],,val
US20140107335A1,CC(F)(F)c1ncc(C(C#N)N2CCC(F)(F)CC2)cn1>>CC(F)(F)c1ncc(C(CN)N2CCC(F)(F)CC2)cn1,[Ni],,,N,,val
US20150336925A1,CC(Br)Br.Oc1cccc2ccccc12>>BrCCOc1cccc2ccccc12,,O,,[Na+].[OH-],,val
US20140275071A1,COc1ccc(Cn2c(=O)c(N)c(N)n(C)c2=O)cc1.O=C(O)Cc1cccc(OC(F)(F)F)c1>>COc1ccc(Cn2c(=O)c(NC(=O)Cc3cccc(OC(F)(F)F)c3)c(N)n(C)c2=O)cc1,,CCO,O,CCN=C=NCCCN(C)C,,val
US20140315925A1,CN.FC(F)(F)c1cnc(Cl)cc1I>>CNc1cc(Cl)ncc1C(F)(F)F,,CCCCCC,,CO,,val
US05872137,CCOc1ccc(O)cc1Cl.Oc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl.Oc1ccccc1>>ClC(Cl)=CCOc1cc(Cl)c(OCCc2cccc(Cl)c2)c(Cl)c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110166133A1,CCN(CC)CC.ClCCl.OC1CCN(c2cc(-c3cccc(-c4cnc5ccc(N6CCCC6c6cccc(F)c6)nn45)n3)ccn2)CC1>>Fc1cccc(C2CCCN2c2ccc3ncc(-c4cccc(-c5ccnc(N6CCC(NC7CC7)CC6)c5)n4)n3n2)c1,,ClCCl,,CS(=O)(=O)Cl,,val
US20110236690A1,O=Cc1scc2c1OCCO2>>OCc1scc2c1OCCO2,,CO,ClCCl,[Na+].[OH-],,val
US04336264,Nc1cc(-c2ccc(F)cc2)no1.O=C=NC(=O)c1ccccc1Cl>>O=C(NC(=O)c1ccccc1Cl)Nc1cc(-c2ccc(F)cc2)no1,,CCOC(C)=O,,,,val
US20070129341A1,COC(=O)C(Cc1ccc(NC(=O)OC(C)(C)C)nc1)(C(=O)OC)c1c[nH]cn1.O=[N+]([O-])c1ccc(F)cc1>>COC(=O)C(Cc1ccc(NC(=O)OC(C)(C)C)nc1)(C(=O)OC)c1cn(-c2ccc([N+](=O)[O-])cc2)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20130331420A1,Cc1cccc(N)c1-c1nnnn1Cc1ccccc1.O=S(=O)(Cl)c1ccccc1>>Cc1cccc(NS(=O)(=O)c2ccccc2)c1-c1nnnn1Cc1ccccc1,,CCOC(C)=O,c1ccncc1,,,val
US20070232583A1,CCCC[Sn](CCCC)(CCCC)c1cccc(-c2cccc(S(=O)(=O)NC(C)(C)C)c2)n1.Cc1cc(-c2ccc(OC(F)(F)F)cc2)cc(OS(=O)(=O)C(F)(F)F)n1>>Cc1cc(-c2ccc(OC(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(=O)(=O)NC(C)(C)C)c3)n2)n1,,Cc1ccccc1,,,,val
US05539122,CC(C)c1nc(CN(NC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1.Cl>>CC(C)c1nc(CN(N)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1.Cl,,C1COCCO1,CO,CCOCC,,val
US06063932,O=C(NC(CO)c1ccc(-c2ccc(SC(F)F)cc2)cc1)c1c(F)cccc1F.O=S(Cl)Cl>>O=C(NC(CCl)c1ccc(-c2ccc(SC(F)F)cc2)cc1)c1c(F)cccc1F,,Cc1ccccc1,,,,val
US05622954,O=C(O)C1(c2ccc(Cl)cc2)CCCC1>>OCC1(c2ccc(Cl)cc2)CCCC1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080319188A1,CN(C)[C@H]1CCNC1.O=C(Oc1ccccc1)N(C(=O)Oc1ccccc1)c1cc(Oc2ccc(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)c(F)c2)ccn1>>CN(C)[C@H]1CCN(C(=O)Nc2cc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)c(F)c3)ccn2)C1,,CN(C)C=O,,,,val
US03974283,CC(C)(C)C1=CCNCC1.CN=C=S>>CNC(=S)N1CC=C(C(C)(C)C)CC1,,C1CCOC1,,,,val
US06211234B1,CCOC(=O)CCC(Oc1cc(OCc2ccsc2)ccc1C1=NCCO1)c1ccccc1C.CO>>Cc1ccccc1CCCC(=O)O.O,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20040044000A1,NC1=CC(=O)N=N1.O=C(O)c1ccc(Cn2ccc3ccc(C#CCc4ccccc4)cc3c2=O)cc1>>O=C1CC(NC(=O)c2ccc(Cn3ccc4ccc(C#CCc5ccccc5)cc4c3=O)cc2)=NN1,,CCOC(C)=O,CO,,,val
US20060004046A1,CC(C)(C)COc1c(C#N)cnc2ccc(C=O)cc12.O=C1CSC(NC2CC2)=N1>>CC(C)(C)COc1c(C#N)cnc2ccc(/C=C3\SC(NC4CC4)=NC3=O)cc12,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20150065468A1,COc1ccc(CCl)cc1.Nc1n[nH]c2ncc(Br)cc12>>COc1ccc(Cn2nc(N)c3cc(Br)cnc32)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20090036478A1,C1CCOC1.COCOc1ccc(CC(C)(C)F)nc1.O>>COCOc1cnc(CC(C)(C)F)cc1C(C)O,,C1CCOC1,,CC1(C)CCCC(C)(C)N1,[Li]CCCC,val
US20110092479A1,CCCS(=O)(=O)N(c1ccc(F)c(C(=O)Nc2cnc3c(c2)c(Br)nn3S(=O)(=O)c2ccc(C)cc2)c1F)S(=O)(=O)CCC>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(Br)c3c2)c1F,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20110039831A1,C1CNCCN1.CC(c1c(F)cc2ncccc2c1F)c1cnc2ccc(Cl)nn12>>CC(c1c(F)cc2ncccc2c1F)c1cnc2ccc(N3CCNCC3)nn12,,CCOC(C)=O,CN1CCCC1=O,[F-].[K+],,val
US05321027,CN(C(=O)OCc1ccccc1)c1ccc(C(=O)N2CCN(CCc3ccc(Cl)cc3)CC2)c(Cl)c1>>CNc1ccc(C(=O)N2CCN(CCc3ccc(Cl)cc3)CC2)c(Cl)c1,[Pd],CO,,Cl,,val
US20120065192A1,CCOC(=O)c1c[nH]c(-c2ccnc(N)n2)c1.CI>>CCOC(=O)c1cc(-c2ccnc(N)n2)n(C)c1,,C1CCOC1,CS(C)=O,[H-].[Na+],,val
US20030055261A1,CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)C1CCC(NC(=O)OC(C)(C)C)CC1>>CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)C1CCC(N)CC1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20110319378A1,C=CC[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N([C@@H](CC)C(=O)OC)C1=O>>C=CC[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N([C@H](CC)CO)C1=O,,C1CCOC1,CCOCC,[BH4-].[Li+],,val
US20100143341A1,CC1CN(c2ccccc2[N+](=O)[O-])CC(C)N1C(=O)OC(C)(C)C>>CC1CN(c2ccccc2N)CC(C)N1C(=O)OC(C)(C)C,[Pd],CCO,,,,val
US20150344490A1,COc1ccc(C(=O)C(C)=O)c(C)c1.NNc1ncc[nH]1>>COc1ccc(-c2c(C)nnc3nccn23)c(C)c1,,CN(C)C=O,,Cl,,val
US20070043065A1,COC(OC)OC.COc1ccc(N)c(C(=O)O)c1.Cc1ccc(C(=O)NC2CC2)cc1N>>COc1ccc2ncn(-c3cc(C(=O)NC4CC4)ccc3C)c(=O)c2c1,,CCOC(C)=O,Cc1ccccc1,CC(=O)O,,val
US20050187277A1,N=C(N)n1cccn1.Nc1ccc(Br)cc1>>N=C(N)Nc1ccc(Br)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20130178478A1,C/C=C/c1cc(C)cc(N)n1>>CCCc1cc(C)cc(N)n1,[Pd],CCO,,,,val
US20050107402A1,CCOC(=O)[C@@H]1C[C@H]1c1ccc(Br)cc1.CSCCNC(=O)c1cn(-c2cccc(Br)c2)c2ncccc2c1=O>>CCOC(=O)C1CC1c1ccc(-c2cccc(-n3cc(C(=O)NCCSC)c(=O)c4cccnc43)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20150336949A1,COc1ccc(-c2cc3c(I)cn(C(=O)OC(C)(C)C)c3nc2C2CC2)cc1N(C(=O)OC(C)(C)C)S(C)(=O)=O.Cc1nn(Cc2cc(F)cc(F)c2)c(C)c1B1OC(C)(C)C(C)(C)O1>>COc1ccc(-c2cc3c(-c4c(C)nn(Cc5cc(F)cc(F)c5)c4C)cn(C(=O)OC(C)(C)C)c3nc2C2CC2)cc1N(C(=O)OC(C)(C)C)S(C)(=O)=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20140179690A1,N[C@@]1(c2cccc(F)c2F)CO[C@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@H]1CO.O=C(O)[C@@](O)(C(=O)c1ccccc1)[C@@](O)(C(=O)O)C(=O)c1ccccc1.S=C=NCc1ccccc1>>O=C(NC(=S)N[C@@]1(c2cccc(F)c2F)CO[C@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@H]1CO)c1ccccc1,,CCOC(C)=O,,[Na+].[OH-],,val
US20090209607A1,Cn1ncc(-c2ccccc2)c1-c1csc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)c1>>Cn1ncc(-c2ccccc2)c1-c1csc(C(=O)N[C@H](CN)Cc2ccccc2C(F)(F)F)c1,,C1CCOC1,CO,NN,,val
US20100160397A1,COC(=O)C[C@@H]1CC[C@@H](c2ccc(N)cc2)CC1.O=C(O)c1coc(Nc2cc(F)c(F)cc2F)n1>>COC(=O)C[C@@H]1CC[C@@H](c2ccc(NC(=O)c3coc(Nc4cc(F)c(F)cc4F)n3)cc2)CC1,,CC(=O)N(C)C,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20160184305A1,CN(c1ccc(-c2ccc(C(O)C[N+](=O)[O-])cc2OCc2ccccc2)nn1)C1CC(C)(C)NC(C)(C)C1>>COc1cc(C(O)CN)ccc1-c1ccc(N(C)C2CC(C)(C)NC(C)(C)C2)nn1,[Pd],CO,,,,val
US20080058391A1,CC(C)(NCc1cc(-c2ccc(C(F)(F)F)cc2)ccn1)C(N)=O.Cl>>CC(C)(NCc1cc(-c2ccc(C(F)(F)F)cc2)ccn1)C(N)=O.Cl,,ClCCl,,CC(C)O,,val
US20110065708A1,C=C(OCC)[Sn](CCCC)(CCCC)CCCC.CC(c1c(F)cc2ncccc2c1F)c1nnc2ccc(Cl)nn12>>C=C(OCC)c1ccc2nnc(C(C)c3c(F)cc4ncccc4c3F)n2n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,,,val
US20100216836A1,CCCC[Sn](C#N)(CCCC)CCCC.O=S(=O)(Oc1cccc([C@H]2CCCN(C[C@H]3COc4ccccc4O3)C2)c1)C(F)(F)F>>N#Cc1cccc([C@H]2CCCN(C[C@H]3COc4ccccc4O3)C2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCCl,,,,val
US20080312299A1,CC(=O)C(O)O.CCOC(=N)c1ccc(Cl)s1.N>>OCc1cnc(-c2ccc(Cl)s2)[nH]1,,CO,,,,val
US20040058964A1,CC(C)(C)[Si](C)(C)OCc1cccc(C#N)c1>>CC(C)(C)[Si](C)(C)OCc1cccc(CN)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20160176861A1,C1=C(N2CCCC2)CCC1.O.O=C(c1ccccc1)C(CCl)CCl>>O=C(c1ccccc1)C1C[C@@H]2CC[C@H](C1)C2=O,,CC#N,,,,val
US20150266857A1,C1CNCCN1.O=S(=O)(c1ccccc1)n1cc(-c2ccc3nc(CCl)oc3c2)c2ccc(F)cc21>>O=S(=O)(c1ccccc1)n1cc(-c2ccc3nc(CN4CCNCC4)oc3c2)c2ccc(F)cc21,,CN(C)C=O,,,,val
US20150299189A1,COC(=O)c1cc(C2CC2)ccc1Nc1ccc([N+](=O)[O-])c(CC(=O)OC(C)(C)C)c1>>COC(=O)c1cc(C2CC2)ccc1Nc1ccc(N)c(CC(=O)OC(C)(C)C)c1,[Fe],O,,CCO,[Cl-].[NH4+],val
US20140255381A1,C=C(C)c1cccc(C(C)(C)N=C=O)c1.O[C@H]1CN2CCC1CC2>>C=C(C)c1cccc(C(C)(C)NC(=O)O[C@H]2CN3CCC2CC3)c1,,C1CCOC1,,[H-].[Na+],,val
US20130065914A1,Cc1c(Cl)sc2ncnc(Cl)c12.Nc1ccc(F)cc1O[C@@H]1CC[C@@H](O)CC1>>Cc1c(Cl)sc2ncnc(Nc3ccc(F)cc3O[C@@H]3CC[C@@H](O)CC3)c12,,C1COCCO1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20100210641A1,OB(O)c1ccoc1.OC1CCC(Nc2ccc3ncc(-c4ccnc(Cl)c4)n3c2)CC1>>OC1CCC(Nc2ccc3ncc(-c4ccnc(-c5ccoc5)c4)n3c2)CC1,,CCO,O,O=C([O-])[O-].[Na+].[Na+],,val
US20050107355A1,COC(=O)CN(C(=O)C(F)(F)F)c1ccc([N+](=O)[O-])cc1>>COC(=O)CN(C(=O)C(F)(F)F)c1ccc(N)cc1,[Pd],CO,ClCCl,[H][H],,val
US20040110807A1,CCOC(=O)C(Cc1ccc(O)cc1OCC)OCC.Cc1sc(-c2ccc(C(F)(F)F)cc2)nc1CCO>>CCOC(=O)C(Cc1ccc(OCCc2nc(-c3ccc(C(F)(F)F)cc3)sc2C)cc1OCC)OCC,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080280868A1,Nc1cccc(Cl)c1.O=C(O)c1cnc(Cl)cc1C1CC1>>O=C(O)c1cnc(Nc2cccc(Cl)c2)cc1C1CC1,,O,,CCOCC,[Na+].[OH-],val
US20110178132A1,NC(=NO)c1cc(-c2ccc(F)c(C(F)(F)F)c2)ccn1.O=C(n1ccnc1)n1ccnc1>>O=c1nc(-c2cc(-c3ccc(F)c(C(F)(F)F)c3)ccn2)[nH]o1,,C1CCOC1,O,C1CCC2=NCCCN2CC1,Cl,val
US20080206158A1,CC(=O)c1ccccc1.CC(C)(C)c1ccc(C(=O)Cl)cc1>>C=C(OC(=O)c1ccc(C(C)(C)C)cc1)c1ccccc1,,O,,,,val
US20110059999A1,CCOC(C)OC(Cc1ccccc1)C1CCC(c2cccs2)(N(C)C)CC1>>CN(C)C1(c2cccs2)CCC(C(O)Cc2ccccc2)CC1,,C1CCOC1,CCOCC,Cl,[Na+].[OH-],val
US20110105513A1,CCN=C=NCCCN(C)C.CS(C)=O.On1nnc2ccccc21>>c1ccc2nccnc2c1,,CS(C)=O,,,,val
US20130190316A1,CN(C)C=O.COc1cncc(OC)c1>>COc1cncc(OC)c1C=O,,C1CCOC1,,[Li]CCCC,,val
US20080096903A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCCOCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cc1ccc(S(=O)(=O)OCCOCCCOC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,c1ccncc1,,,,val
US20050176786A1,Nc1cc(-c2ccccc2Cl)n[nH]1.O=C(N=C=S)c1ccccc1>>NC(=S)Nc1cc(-c2ccccc2Cl)n[nH]1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20080085890A1,COC=C1C(=O)NC(=O)c2ccc(Br)cc21.Nc1ccc2ncccc2c1>>O=C1NC(=O)c2ccc(Br)cc2/C1=C/Nc1ccc2ncccc2c1,,CN(C)C=O,,,,val
US20060235033A1,COc1cc2nccc(Oc3ccc(N)c(F)c3)c2cc1OC.C[C@@H](N)c1ccc(F)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)N[C@H](C)c4ccc(F)cc4)c(F)c3)c2cc1OC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US04282365,CC(C)c1cccc(OCc2cc(Br)ccc2C(=O)[O-])c1>>CC(C)c1cccc(OCc2cc(Br)ccc2C(=O)O)c1,,CO,,O,[Na+].[OH-],val
US20110294788A1,Br[Mg]c1ccccc1.COC(=O)C(C(C)=O)=C(C)C>>COC(=O)C(C(C)=O)C(C)(C)c1ccccc1,[Cu]I,CCOCC,,[Cl-].[NH4+],,val
US20110152233A1,CC1(C(=O)N2CCC(C(=O)N3CC(N)C(c4ccc(Cl)c(Cl)c4)C3)CC2)CC1.CCOC1(O[Si](C)(C)C)CC1>>CC1(C(=O)N2CCC(C(=O)N3C[C@@H](NC4CC4)[C@H](c4ccc(Cl)c(Cl)c4)C3)CC2)CC1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20020058654A1,O=S(=O)(Cl)c1ccccc1Br.c1ccncc1>>NS(=O)(=O)c1ccccc1Br,,ClCCl,,,,val
US03941802,NN.Nc1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1Cl>>NN=C(c1cc([N+](=O)[O-])ccc1N)c1ccccc1Cl,,OCCOCCO,,O,,val
US20060052406A1,CC(=O)OC(C)=O.CI.NCc1ccncc1>>CC(=O)NCc1cc[n+](C)cc1.[I-],,CO,,,,val
US04717724,C=O.COc1cccc(CCNc2ccc(Cl)cc2)c1>>COc1ccc2c(c1)CCN(c1ccc(Cl)cc1)C2,,CO,,Cl,,val
US05187236,C=CC(=C)C.C=CC=C.CC(C)O.O=C(Oc1ccccc1)c1ccccc1>>C=CC(=C)C.C=CC(=C)C.C=CC=C,,CC(C)O,,,,val
US20150225379A1,C=CCOC(=O)N(CC1(CO)CCN(C(=O)OC(C)(C)C)CC1)[C@@H]1C[C@H]1c1ccccc1.Oc1ccc(F)cn1>>C=CCOC(=O)N(CC1(COc2ccc(F)cn2)CCN(C(=O)OC(C)(C)C)CC1)[C@@H]1C[C@H]1c1ccccc1,,Cc1ccccc1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05559256,CC(C)[C@H](NC(=O)OCC(O)CO)C(=O)NC(Cc1ccccc1)C(O)CNCC(O)C(Cc1ccccc1)NC(=O)OC(C)(C)C>>CC(C)[C@H](NC(=O)OCCO)C(=O)NC(Cc1ccccc1)C(O)CNCC(O)C(Cc1ccccc1)NC(=O)OC(C)(C)C,,CO,,N#N,,val
US20100009956A1,N#Cc1ncc(Br)c(N(N)C2CCCCC2)n1.O=C(Cl)c1cncc(-c2cccc(CCl)c2)c1>>N#Cc1ncc(Br)c(N(NC(=O)c2cncc(-c3cccc(CCl)c3)c2)C2CCCCC2)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20040224974A1,CCc1nn2ccccc2c1N(CC1CCOCC1)CC1CC1.Fc1c(F)c(F)c(I)c(F)c1F>>CCc1nn2c(I)cccc2c1N(CC1CCOCC1)CC1CC1,,C1CCOC1,,O,,val
US20060052602A1,Nc1cncnc1N.O=C(O)c1ccccc1F>>Fc1ccccc1-c1nc2ncncc2[nH]1,,O,,[Na+].[OH-],,val
US20140045814A1,COc1cc(CCc2cnc3c(cc(Br)n3S(=O)(=O)c3ccccc3)n2)cc(OC)c1>>COc1cc(CCc2cnc3[nH]c(Br)cc3n2)cc(OC)c1,,C1CCOC1,,O,[K+].[OH-],val
US20100292255A1,Nc1ncnc2[nH]c(S)nc12.O=[N+]([O-])c1cc2c(cc1Br)OCCO2>>Nc1ncnc2[nH]c(Sc3cc4c(cc3[N+](=O)[O-])OCCO4)nc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100099715A1,CCCCn1ccc(Br)c(C#N)c1=O.Cc1ccc(Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2F)c(C)n1>>CCCCn1ccc(-c2ccc(Oc3ccc(C)nc3C)c(F)c2)c(C#N)c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])O.[Na+],,val
US20100210694A1,CC(=O)Oc1ccccc1C(=O)OCCl.O=C(O)CCCC(CO[N+](=O)[O-])O[N+](=O)[O-]>>CC(=O)Oc1ccccc1C(=O)OCOC(=O)CCCC(CO[N+](=O)[O-])O[N+](=O)[O-],,CN(C)C=O,O,CCN(CC)CC,,val
US20060258691A1,CC(C)(C)OC(=O)c1nn(C(C)(C)C)c2nc(F)ccc12>>CC(C)(C)n1nc(C(=O)O)c2ccc(F)nc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040171014A1,COc1ccc(Nc2cc(C(=O)O)c(Nc3ccc(OC)cc3)cc2C(=O)O)cc1>>COc1ccc2[nH]c3cc4c(=O)c5cc(OC)ccc5[nH]c4cc3c(=O)c2c1,,O,,,,val
US20110098299A1,CC(C)(C)OC(=O)N1CCC(N)CC1.CC(C)(C)OC(=O)N1CCC(N2CCC3(CCCC(C(=O)O)C3)C2=O)CC1.OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC(N2CCC3(CCCC(NC(=O)OCc4ccccc4)C3)C2=O)CC1,,Cc1ccccc1,,CCN(CC)CC,,val
US20020022631A1,CCOC(=O)C(Cc1cnccn1)(NC(C)=O)C(=O)OCC>>CCOC(=O)C(Cc1cnccn1)NC(C)=O,,CCO,,Cl,[Na+].[OH-],val
US20140275111A1,CN(C)CCO.O=[N+]([O-])c1cnc(Cl)c(C(F)(F)F)c1>>CN(C)CCOc1ncc([N+](=O)[O-])cc1C(F)(F)F,,C1CCOC1,,[H-].[Na+],,val
US20040167187A1,CCOC(=O)CNS(=O)(=O)Nc1ccc(C(=O)OC)cc1>>COC(=O)c1ccc(N2CC(=O)NS2(=O)=O)cc1,,CO,,C[O-].[Na+],,val
US04550105,C1CCOC1.CC(C)ON=C(C(=O)O)c1csc(NC(=O)CCl)n1.CCN(CC)CC.CN(C)C=O.O=C(Cl)OC(Cl)(Cl)Cl>>CC(=O)O[C@@H]1NC(=O)[C@H]1NC(=O)C(=NOC(C)C)c1csc(NC(=O)CCl)n1,,C1CCOC1,,ClCCl,,val
US20090306066A1,O=C(Cl)CCC1CCCC1.O=C1N[C@@H](Cc2ccccc2)CO1>>O=C(CCC1CCCC1)N1C(=O)OC[C@@H]1Cc1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US04447361,Nc1ccccc1C(=O)c1ccccc1.Nc1cccnc1Cl>>Nc1cccnc1Nc1ccccc1C(=O)c1ccccc1,,ClCCl,,,,val
US20100173933A1,CCOC(=O)C(=O)CBr.COc1ccc(C(N)=S)cc1>>CCOC(=O)c1csc(-c2ccc(OC)cc2)n1,,CCO,,CCN(CC)CC,,val
US20070238726A1,COCCN1CCC(N)CC1.COc1ccc(Cn2nc(I)c3c(Oc4ccc(N)cc4F)ccnc32)cc1>>COCCN1CCC(Nc2nn(Cc3ccc(OC)cc3)c3nccc(Oc4ccc(N)cc4F)c23)CC1,[Cu]I,CS(C)=O,,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US20160129002A1,Br[Mg]C1CC1.COc1cc(Nc2nc(C=O)cc(COCC(F)(F)F)n2)ccc1-n1cnc(C)c1>>COc1cc(Nc2nc(COCC(F)(F)F)cc(C(O)C3CC3)n2)ccc1-n1cnc(C)c1,,C1CCOC1,,,,val
US20160002177A1,Nc1c(OCc2ccccc2)cc(I)cc1C(=O)OCc1ccccc1>>Nc1c(OCc2ccccc2)cc(I)cc1C(=O)O,,O,,CO,[Li+].[OH-],val
US20120252818A1,COc1nc(N2CCNCC2)nc(OC)c1Sc1nc(NC(C)=O)cc(NC(C)=O)n1.O=C1c2ccccc2C(=O)N1CCCCBr>>COc1nc(N2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)nc(OC)c1Sc1nc(NC(C)=O)cc(NC(C)=O)n1,,CN(C)C=O,,,,val
US06861417B2,Fc1ccc(C2=NCCN=C2c2ccncc2)cc1>>Fc1ccc(-c2nccnc2-c2ccncc2)cc1,,CCO,,,,val
US05428048,CC(=O)OC(C)=O.CN(CCOc1ccc(CNO)cc1)c1nc2ccccc2o1>>CC(=O)N(O)Cc1ccc(OCCN(C)c2nc3ccccc3o2)cc1,,C1CCOC1,,,,val
US20100311750A1,CC(C)OC(=O)N1CC[C@H](N(Cc2cc(Cl)cc(C(F)(F)F)c2)c2ncc(Br)cn2)C1.Cn1ccc(B2OC(C)(C)C(C)(C)O2)n1>>CC(C)OC(=O)N1CC[C@H](N(Cc2cc(Cl)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])O.[Na+],val
US04326069,CCN(CC)CCCN.COC(=O)/C=C\C(=O)O>>CCN(CC)CCCN[C@@H](CC(=O)OC)C(=O)O,,CCOCC,,CCN(CC)CC,,val
US20050137236A1,O=C(O)c1ccc(Br)cc1OC1CCCCC1>>OCc1ccc(Br)cc1OC1CCCCC1,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20100168161A1,CON(C)C(=O)COc1ccc(Br)cc1.Cl[Mg]CCc1ccccc1>>O=C(CCc1ccccc1)COc1ccc(Br)cc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20130143940A1,COCCN(CCOC)S(F)(F)F.Cc1nn(C)c(-c2c(F)cccc2F)c1C(O)c1ccc(F)cc1F>>Cc1nn(C)c(-c2c(F)cccc2F)c1C(F)c1ccc(F)cc1F,,ClCCl,,O=C([O-])O.[Na+],,val
US20080269210A1,Cc1c(-c2cccc(O)c2)sc2c(N3CCOCC3)nc(Cl)nc12.ClCCN1CCOCC1>>Cc1c(-c2cccc(OCCN3CCOCC3)c2)sc2c(N3CCOCC3)nc(Cl)nc12,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20110071191A1,Nc1ccc(C(F)F)nc1.O=C1CCC(=O)N1Br>>Nc1ccc(C(F)F)nc1Br,,CC#N,,O,,val
US20100075976A1,CNCCN1CCN(c2nccnc2-c2ccc(F)cc2)CC1.Cc1ncc(S(=O)(=O)Cl)n1C.ClCCl>>Cc1ncc(S(=O)(=O)N(C)CCN2CCN(c3nccnc3-c3ccc(F)cc3)CC2)n1C.Cl,,ClCCl,,C1COCCN1,,val
US20100292222A1,CC(=O)N1CCN(C[C@H](C)O)CC1.Oc1ccc(C2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1>>CC(=O)N1CCN(C[C@@H](C)Oc2ccc(C3CCN(c4ccc5nnc(C(F)(F)F)n5n4)CC3)cc2)CC1,,C1CCOC1,CCOC(C)=O,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090270363A1,N#Cc1ccc(N2CCCC2)cc1Br.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>NC(=S)c1ccc(N2CCCC2)cc1Br,,CO,,,,val
US06300352B1,CCOC(=O)[C@H](C)Oc1ccc(-c2ccccc2)cc1>>C[C@@H](CO)Oc1ccc(-c2ccccc2)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110034455A1,CC(C)(C)OC(=O)N1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2ccccc21>>O=C(NC1C2CC3CC(C2)CC1C3)N1CCC2(CC1)CNc1ccccc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040157836A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1cccc(N)c1C(=O)O>>COc1cccc(NC(=O)OC(C)(C)C)c1C(=O)O,,CC#N,,CCN(CC)CC,,val
US05278314,CC(C)(C)c1cc(-n2nc3ccc(Cl)cc3n2)c(O)c(C(C)(C)C)c1.CCCCCCCCCCCCS>>CCCCCCCCCCCCSc1ccc2nn(-c3cc(C(C)(C)C)cc(C(C)(C)C)c3O)nc2c1,,CN(C)C=O,O,[I-].[K+],,val
US20110295017A1,Brc1c2ccccc2cc2ccccc12.OB(O)c1ccccc1>>c1ccc(-c2c3ccccc3cc3ccccc23)cc1,,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20100222398A1,COc1ccc(Cl)cc1CC#N.[N-]=[N+]=Nc1ccc(C(F)(F)F)cc1Cl>>COc1ccc(Cl)cc1-c1nnn(-c2ccc(C(F)(F)F)cc2Cl)c1N,,CCO,CCOC(C)=O,C[O-].[Na+],,val
US20070179165A1,CCOC(=O)C(CC(C)=O)=NOC.NNc1c(Cl)cc(Cl)cc1Cl>>CCOC(=O)c1cc(C)nn1-c1c(Cl)cc(Cl)cc1Cl,,CC(=O)O,CCOC(C)=O,Cl,,val
US20090197859A1,Cc1ccccc1C1CCCCN1C(=O)c1cccc(N2CCN(C(=O)OC(C)(C)C)CC2)n1>>Cc1ccccc1C1CCCCN1C(=O)c1cccc(N2CCNCC2)n1,,ClCCl,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],,val
US05599812,CC(=O)O.COC1CCC(OC)O1.Cc1ccnc(N)c1[N+](=O)[O-]>>Cc1ccnc(-n2cccc2)c1[N+](=O)[O-],,CC(=O)O,,,,val
US20110039808A1,COC(=O)c1ccc(NCCn2c(C)c(C(=O)c3cccc4ccccc34)c3ccccc32)cc1OC>>COC(=O)c1ccc(NCCn2c(C)c(C(=O)c3cccc4ccccc34)c3ccccc32)cc1O,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20050148634A1,CC(=O)OC(C)=O.NNc1ccc(OC(F)F)cc1[N+](=O)[O-]>>CC(=O)NNc1ccc(OC(F)F)cc1[N+](=O)[O-],,ClC(Cl)Cl,,c1ccncc1,,val
US20150218123A1,CCOC(=O)C(C(=O)OCC)C1(C#N)CC2CC(CC)=CC21>>CCOC(=O)CC1(C#N)CC2CC(CC)=CC21,,CCO,,[K+].[OH-],,val
US04207329,CCOC(=O)C(O)c1ccc(-n2cccc2)cc1>>O=C(O)C(O)c1ccc(-n2cccc2)cc1,,C1COCCO1,,CCO,[K+].[OH-],val
US20030069210A1,Cc1cc(N(CCC#N)CC(=O)NCCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1>>CC(=O)NCCc1ccc2c(c1)OCO2,[Ni],CO,,N,,val
US20090281088A1,CC1(CN2CCCN(c3ncc(-c4ccc(N5CC(C(C)(C)O[SiH2]C(C)(C)C)OC5=O)cc4F)cn3)CC2)Cn2cc([N+](=O)[O-])nc2O1>>CC1(CN2CCCN(c3ncc(-c4ccc(N5CC(CO)OC5=O)cc4F)cn3)CC2)Cn2cc([N+](=O)[O-])nc2O1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080300246A1,ClCCl.Nc1ccc(Cl)c(-c2cc3cnccc3nc2N)c1Cl.O=C(Cl)c1cccc(C(F)(F)F)c1>>Nc1nc2ccccc2cc1-c1c(Cl)ccc(NC(=O)c2cccc(C(F)(F)F)c2)c1Cl,,CCOC(C)=O,,,,val
US20160244409A1,CC(C)CN1CCC(C)(C)C=C1c1ccccc1.CCC(=O)Cl>>CCC(=O)C1=C(c2ccccc2)N(CC(C)C)CCC1(C)C,,ClCCl,,CCN(CC)CC,,val
US03940407,CCOC=O.N#CCc1ccc(OC2CCCCO2)cc1>>N#CC(C=O)c1ccc(OC2CCCCO2)cc1,,C1CCOC1,CC(=O)O,CC(C)NC(C)C,[Li]CCCC,val
US04309422,CCCSP(=S)(Oc1ccccc1C=O)SCC.NNC(=O)c1ccc([N+](=O)[O-])cc1>>CCCSP(=S)(Oc1ccccc1C=NNC(=O)c1ccc([N+](=O)[O-])cc1)SCC,,CO,ClCCl,,,val
US20110086842A1,COC(=O)C(N)Cc1ccccc1.Nc1cccc([N+](=O)[O-])c1C(=O)O>>COC(=O)C(Cc1ccccc1)NC(=O)c1c(N)cccc1[N+](=O)[O-],,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US20080242665A1,BrP(Br)Br.Cc1c(CO)sc2c(N3CCOCC3)nc(Cl)nc12>>Cc1c(CBr)sc2c(N3CCOCC3)nc(Cl)nc12,,Cc1ccccc1,,,,val
US20090131416A1,O=C(c1cnc(Cl)cn1)N1CCCN(C2CCC2)CC1.Oc1ccc(F)cc1>>O=C(c1cnc(Oc2ccc(F)cc2)cn1)N1CCCN(C2CCC2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100240638A1,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](OC(=O)N2Cc3cccc(F)c3C2)CN1)C(=O)NS(=O)(=O)c1ccccc1NCCCCN(C)CCCC(=O)O.CN(C)C=O>>C=C[C@@H]1C[C@]1(N=C=O)C1NC(=O)[C@@H]2C[C@@H](OC(=O)N3Cc4cccc(F)c4C3)CN2C(=O)CCCN(C)CCCCNc2ccccc2S(=O)(=O)NC1=O,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04008068,CNCC=O.O=C=Nc1nnc(CCl)s1>>CN(CC=O)C(=O)Nc1nnc(CCl)s1,,c1ccccc1,,,,val
US20040097546A1,CCOC(=O)C1=C(c2ccc(F)cc2)CCN(C(=O)OC(C)(C)C)C1>>CCOC(=O)C1CN(C(=O)OC(C)(C)C)CCC1c1ccc(F)cc1,,CO,,Cl,[Mg],val
US20130053345A1,CC(C)(C)OC(=O)N1CC=C(c2ccc3nc(OC4CCN(c5ncc(F)cn5)CC4)sc3c2)CC1>>Fc1cnc(N2CCC(Oc3nc4ccc(C5=CCNCC5)cc4s3)CC2)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100152441A1,C1COCCO1.Clc1ccc2ccc(Br)cc2n1>>O=c1ccc2ccc(Br)cc2[nH]1,,Cl,,,,val
US20140288051A1,Cn1ncc2c1CC(C(=O)OC(C)(C)C)CN2O.O=C1c2ccccc2C(=O)N1O>>Cn1ncc2c1CN(C(=O)OC(C)(C)C)CC2ON1C(=O)c2ccccc2C1=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080207634A1,COc1ccc([C@H](C)N)cc1.O=C1CCOc2cccnc21>>COc1ccc([C@H](C)N[C@H]2CCOc3cccnc32)cc1,,ClCCCl,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20100190763A1,CNCC(=O)OC.COC(=O)c1cnc(Cl)c([N+](=O)[O-])c1>>COC(=O)CN(C)c1ncc(C(=O)OC)cc1[N+](=O)[O-],,ClCCl,,,,val
US20050245586A1,CC(CN)c1ccc(-c2ccc(F)cc2)cc1.O=C(O)CC1NC(=O)NC1=O>>CC(CNC(=O)CC1NC(=O)NC1=O)c1ccc(-c2ccc(F)cc2)cc1,,CN1CCCC1=O,,On1nnc2ccccc21,,val
US20100249124A1,CCN1C(=O)COc2ccc(C(O)(C(C)c3ccc(O)cc3Cl)C(F)(F)F)cc21.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCN1C(=O)COc2ccc(C(O)(C(C)c3ccc(OS(=O)(=O)C(F)(F)F)cc3Cl)C(F)(F)F)cc21,,ClCCl,,CCN(CC)CC,,val
US20060004013A1,CCN(CC)CC.CCOC(C)=O.COc1cc(C=O)ccc1-n1cnc(C)c1>>COc1cc(/C=C2\CCN(C(C)=O)C2=O)ccc1-n1cnc(C)c1,,O,,CCO,,val
US20140018319A1,CCN(Cc1ccc(OC)cc1)c1nc(Nc2ccc3c(c2)c(C#N)cn3C2CCN(C(=O)OC(C)(C)C)CC2)nn2c(C#N)cnc12.O=C(O)C(F)(F)F>>CCNc1nc(Nc2ccc3c(c2)c(C#N)cn3C2CCN(C[C@H](C)O)CC2)nn2c(C#N)cnc12,,ClCCCl,,COc1ccccc1,,val
US20160002169A1,CO.Cc1ccc(S(=O)(=O)OC[C@@H]2CCC(=O)O2)cc1>>COC(=O)CC[C@H]1CO1,,CC(=O)O,,CO,C[O-].[Na+],val
US05741788,C[Mg]I.Clc1nsnc1-c1cccnc1.O=C(Cl)Oc1ccccc1>>CC1C=CN(C(=O)Oc2ccccc2)C=C1c1nsnc1Cl,,C1CCOC1,,[Cl-].[NH4+],,val
US20100075968A1,CN1CC(C(=O)OC(C)(C)C)NC1=O>>CN1CC(C(=O)O)NC1=O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20100190764A1,O=C1c2cc(F)ccc2Cc2ccccc2C12CC=CC2.OO>>OC1CCC2(C1)c1ccccc1Cc1ccc(F)cc1C2O,,C1CCOC1,,CCOCC,[Na+].[OH-],val
US20140228386A1,Cc1cc(Br)ncc1F.O=C1NCCN1c1cnccc1C1CC1>>Cc1cc(N2CCN(c3cnccc3C3CC3)C2=O)ncc1F,I[Cu]I,,,CN[C@@H]1CCCC[C@H]1NC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20030199440A1,CC(C)C(N)C(=O)OC(C)(C)C.O=C(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>CC(C)C(NC(=O)c1ccc2c(Cl)cnc(Cl)c2c1)C(=O)OC(C)(C)C,,ClCCl,,CCN(CC)CC,Cl,val
US20040138277A1,CCOC(=O)C(C)(Cc1ccc(O)c(OC)c1)Oc1ccccc1.Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccc(-c4cccs4)cc3)oc2C)cc1>>COc1cc(CC(C)(Oc2ccccc2)C(=O)O)ccc1OCCc1nc(-c2ccc(-c3cccs3)cc2)oc1C,,CCO,,,,val
US06329370B1,COc1ccc2c(Cc3c(Cl)cncc3Cl)n[nH]c(=O)c2c1.O=P(Cl)(Cl)Cl>>COc1ccc2c(Cc3c(Cl)cncc3Cl)nnc(Cl)c2c1,,CC#N,,,,val
US20090214675A1,Cc1cc(=O)c2cccc(C)c2o1.O=[N+]([O-])O>>Cc1cc(=O)c2c([N+](=O)[O-])ccc(C)c2o1,,O=S(=O)(O)O,,,,val
US04886834,CCOC(=O)CC(=O)CCl.COc1ccc(C(=NO)c2ccc(OC)cc2)cc1>>CCOC(=O)CC(=O)CON=C(c1ccc(OC)cc1)c1ccc(OC)cc1,,CN(C)C=O,,Cl,CC(C)(C)[O-].[K+],val
US05500431,Cc1ccc2[nH]cc(CCN)c2c1.Cl.O=CCC1CCCCC1>>Cc1ccc2[nH]c3c(c2c1)CCNC3CC1CCCCC1.Cl,,CCO,,,,val
US20100249123A1,CC(C)(C#N)c1ccc(N)cc1Br.OB(O)C1CC1>>CC(C)(C#N)c1ccc(N)cc1C1CC1,,CCOC(C)=O,Cc1ccccc1,[F-].[K+],,val
US20120157430A1,CC(=O)c1cc(Cl)c(CC#N)c(C#N)c1-c1cccc(F)c1.[NH4+]>>CC(N)c1cc(Cl)c(CC#N)c(C#N)c1-c1cccc(F)c1,,CC#N,CO,[BH3-]C#N.[Na+],,val
US20160060255A1,COC(=O)c1ccc(C(O)c2nccs2)cc1>>COC(=O)c1ccc(Cc2nccs2)cc1,,CC(Cl)Cl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20060173019A1,CNc1ccccc1.COCN(c1cc(Cl)cnc1C(=O)O)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>COCN(c1cc(Cl)cnc1C(=O)N(C)c1ccccc1)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20070004753A1,C[Si](C)(C)C#N.Nc1ccc(CCCC(=O)O)cc1.O=C1CCC1>>N#CC1(Nc2ccc(CCCC(=O)O)cc2)CCC1,,CCOC(C)=O,,,,val
US05703235,NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1.O=C(O)c1ccc2cc3ccccc3cc2c1>>O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cc3ccccc3cc2c1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20150266842A1,CCOC(=O)CC1=C(C)Cc2ccc(F)cc21.CSc1ccc(C=O)cc1>>CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1,,CO,,C[O-].[Na+],,val
US20060167061A1,CCc1ccc(C(O)CO)nc1.O=S(Cl)Cl>>CCc1ccc(C2COS(=O)O2)nc1,,ClCCl,,CCN(CC)CC,,val
US20090143353A1,CC(C)(C)C(=O)OC(=O)C(C)(C)C.CNc1nc2c(C#N)c(C)c(-c3ccccc3)c(N3CC[C@H](N(C)C)C3)c2o1>>Cc1c(-c2ccccc2)c(N2CC[C@H](N(C)C)C2)c2oc(N(C)C(=O)C(C)(C)C)nc2c1C#N,,c1ccncc1,,,,val
US20100197687A1,CCOC(=O)c1cc2cc(Br)ccc2[nH]1.CN(C)C=O>>CCOC(=O)c1[nH]c2ccc(Br)cc2c1C=O,,CN(C)C=O,ClCCl,O=C(Cl)C(=O)Cl,O=C([O-])O.[Na+],val
US20090291965A1,CC(C)(C)OC(=O)Nc1cn(-c2ccccc2)nc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1>>Nc1cn(-c2ccccc2)nc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1,,CCOC(C)=O,CO,C1COCCO1,Cl,val
US20100048551A1,BrBr.O=c1[nH]ccc2sc3ccccc3c12>>O=c1[nH]cc(Br)c2sc3ccccc3c12,,CC(=O)O,,O,,val
US20160016948A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1nc2cnc(Nc3ccnc(Cl)n3)cc2n1C(C)C>>Cc1nc2cnc(N(C(=O)OC(C)(C)C)c3ccnc(Cl)n3)cc2n1C(C)C,CN(C)c1ccncc1,O,,CCN(CC)CC,ClCCl,val
US20080153800A1,CC(C)Oc1cc(OCc2ccccc2)cc(C(=O)Nc2ccn(C(=O)OC(C)(C)C)n2)c1>>CC(C)Oc1cc(O)cc(C(=O)Nc2ccn(C(=O)OC(C)(C)C)n2)c1,[Pd],CO,,,,val
US20070287724A1,Nc1nc2ccccc2c2c1nc(CCl)n2CC1(O)CCC1.O=C1NC(=O)c2ccccc21>>Nc1nc2ccccc2c2c1nc(CN1C(=O)c3ccccc3C1=O)n2CC1(O)CCC1,,CN(C)C=O,,[K],,val
US04640892,CC(=O)C(=O)O.NNc1ccc(Cl)cc1>>CC(=NNc1ccc(Cl)cc1)C(=O)O,,O,,,,val
US20020193599A1,CC1(C)OC(=O)CC(=O)O1.COCCCCC(=O)Cl>>COCCCCC(=O)C1C(=O)OC(C)(C)OC1=O,CN(C)c1ccncc1,ClCCl,,,,val
US20060040937A1,CC1(C)CCCNC1CN.Fc1ccc(Br)cn1>>CC1(C)CCCNC1CNc1ccc(Br)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O=C([O-])[O-].[K+].[K+],val
US20020193614A1,NCc1ccccc1Cl.O=c1[nH]c2ccc([N+](=O)[O-])cc2c(=O)o1>>Nc1ccc([N+](=O)[O-])cc1C(=O)NCc1ccccc1Cl,,CN(C)C=O,,,,val
US04575503,CCOC(=O)CN1C(=O)C(N)CCc2ccccc21.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)CN1C(=O)C(=O)CCc2ccccc21,,CC(=O)O,ClC(Cl)Cl,CC(C)(C)ON=O,,val
US20120165345A1,CC(=O)Cl.NS(=O)(=O)c1cccc(-c2cnn(-c3cccnc3)c2)n1>>CC(=O)NS(=O)(=O)c1cccc(-c2cnn(-c3cccnc3)c2)n1,,CC#N,,[H-].[Na+],,val
US05198446,C1CCNCC1.C[Si](C)(CCl)Cc1ccccc1F>>C[Si](C)(Cc1ccccc1F)CN1CCCCC1.Cl,,Cc1ccccc1C,,,,val
US20050107449A1,CCc1nc(-c2ccc(C(F)(F)F)cc2)oc1C(C)O.COC(=O)CCc1ccc(O)cc1C>>CCc1nc(-c2ccc(C(F)(F)F)cc2)oc1C(C)Oc1ccc(CCC(=O)OC)c(C)c1,,CCCCCC,Cc1ccccc1,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US06127548,C1CCNCC1.C=O.CCCCc1ncc[nH]1>>CCCCc1nccn1CN1CCCCC1,,O,,Cl,[Na+].[OH-],val
US04638067,CCn1cc(C(=O)O)c(=O)c2cc(F)c(Cl)nc21.CNCC1CCNC1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCC(CNC)C3)nc21,,CC#N,,,,val
US04507141,CC(C)(CF)C(=O)C(=Cc1ccc(Cl)cc1Cl)n1cncn1.CCS>>CCSC(c1ccc(Cl)cc1Cl)C(C(=O)C(C)(C)CF)n1cncn1,,CCOCC,,C[O-].[Na+],,val
US06936602B1,CCOCCN(C)c1ccc(OB([O-])[O-])cc1.COC(=O)C1=Cc2cc(Br)ccc2N(C=O)CC1>>CCOCCN(C)c1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3C=O)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O,O=C([O-])[O-].[K+].[K+],val
US05358940,CCCCCCCC/C=C\CCCCCCCCO.O[Si](O)(c1ccccc1)c1ccccc1>>CCCCCCCC/C=C\CCCCCCCCO[Si](O)(c1ccccc1)c1ccccc1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04533672,CCOC(=O)Oc1ccccc1.N#Cc1c(N)[nH]c2ccc(Sc3ccccc3)cc12>>CCOC(=O)Nc1[nH]c2ccc(Sc3ccccc3)cc2c1C#N,,CC(=O)O,CN(C)C=O,O,[H-].[Na+],val
US08716470B2,CC1(C)OB(c2ccc(N3CCOCC3)cc2)OC1(C)C.OCc1cccc(Br)c1>>OCc1cccc(-c2ccc(N3CCOCC3)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20030207879A1,CC(C)Cn1c(N)c(N)c(=O)n(CC(C)C)c1=O.CCC(Oc1cc(C(=O)O)n(C)n1)C(=O)O>>CC(C)Cn1c(=O)c2[nH]c(-c3cc(OCC(=O)O)nn3C)nc2n(CC(C)C)c1=O,,CO,,CCN=C=NCCCN(C)C,Cl,val
US05763450,C#Cc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC.CCc1c(C(=O)O)c(=O)c2ccc(Br)cc2n1C1CCCCC1>>CCOC(=O)c1cn(C2CCCCC2)c2cc(C#Cc3cc(Cc4cnc(N)nc4N)cc(OC)c3OC)ccc2c1=O,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,CCN(CC)CC,O=C([O-])[O-].[Na+].[Na+],val
US04169720,CC(C)O.CC(Oc1ccc(COc2ccc(Cl)cc2)cc1)C(=O)O>>CC(C)OC(=O)C(C)Oc1ccc(COc2ccc(Cl)cc2)cc1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20090221645A1,CCC(O)c1cccc2c(C(F)(F)F)cccc12>>CCC(=O)c1cccc2c(C(F)(F)F)cccc12,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20150005286A1,FC[C@@H]1CCNC1.OCCBr>>OCCN1CC[C@@H](CF)C1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130109679A1,Cn1nccc1N.O=CC(C=O)[N+](=O)[O-]>>Cn1ncc2cc([N+](=O)[O-])cnc21,,CC(=O)O,,[Na],,val
US20040053908A1,CCOC(=O)c1cc(-c2ccc(OCc3ccccc3)cc2)[nH]c1N.NC=O>>Oc1ncnc2[nH]c(-c3ccc(OCc4ccccc4)cc3)cc12,,CN(C)C=O,,O=CO,,val
US06100421,COC(=O)c1ccc(OC)c(C)c1Cl.O=C1CCC(=O)N1Br>>COC(=O)c1ccc(OC)c(CBr)c1Cl,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US06130239,C#CCCCCO.COc1cc[nH]c1/C=C1\C(=O)Nc2cccc(Br)c21>>COc1cc[nH]c1/C=C1\C(=O)Nc2cccc(C#CCCCCO)c21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCN(CC)CC,CN(C)C=O,,,val
US20150133446A1,CCOC(=O)c1cn2nc(C(C)(F)F)sc2n1>>CC(F)(F)c1nn2cc(C(=O)O)nc2s1,,CC(=O)O,,Br,,val
US20090136425A1,Nc1c(I)c(C(=O)N2CCOCC2)c(I)c(C(=O)N2CCOCC2)c1I.O=C(Cl)Cl>>O=C=Nc1c(I)c(C(=O)N2CCOCC2)c(I)c(C(=O)N2CCOCC2)c1I,,C1COCCO1,,Cc1ccccc1,,val
US04000296,CCOC(=O)NC(=N)OC.Cc1nc[nH]c1CSCCN>>CCOC(=O)NC(=N)NCCSCc1[nH]cnc1C,,CO,,,,val
US20090054471A1,Nc1ncnc2nn3ccccc3c12.O=C=Nc1cccc([N+](=O)[O-])c1>>O=C(Nc1cccc([N+](=O)[O-])c1)Nc1ncnc2nn3ccccc3c12,,CC#N,,,,val
US20110009382A1,CCOC(=O)c1c(F)ccc2nc(CN(C)S(=O)(=O)c3c(C)cc(OC)cc3C)[nH]c12>>COc1cc(C)c(S(=O)(=O)N(C)Cc2nc3ccc(F)c(C(=O)O)c3[nH]2)c(C)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20090105474A1,CC(C)(C)OC(=O)c1ccc(-c2cccc(Cl)c2)cc1Nc1ccc(F)cc1>>O=C(O)c1ccc(-c2cccc(Cl)c2)cc1Nc1ccc(F)cc1,,O=C(O)C(F)(F)F,,,,val
US20050176761A1,COc1ccc(C#N)cc1Oc1ccccc1>>N#Cc1ccc(O)c(Oc2ccccc2)c1,,ClCCl,,BrB(Br)Br,,val
US20020183319A1,Cc1cc(CCC(=O)O)[nH]c1C=O.O=C1Cc2c(ncnc2Nc2ccc(F)c(Cl)c2)N1>>Cc1cc(CCC(=O)O)[nH]c1C=C1C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c21,C1CCNCC1,CCO,,,,val
US20070213283A1,CCOC(=O)c1cn(CC)c2nc(Cl)c(F)cc2c1=O>>CCOC(=O)c1cn(CC)c2ncc(F)cc2c1=O,[Pd],CCO,,CCN(CC)CC,,val
US20150239869A1,N#CC1(c2cc(F)ccc2F)CCOCC1.OO>>NC(=O)C1(c2cc(F)ccc2F)CCOCC1,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090270374A1,COC(=O)c1cnc2ccc(OC)nc2c1>>COC(=O)c1cnc2ccc(=O)[nH]c2c1,,Br,CC(=O)O,,,val
US20030045552A1,CC(C)(C)OC(=O)NCCC(=O)NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.Cl>>Cl.NCCC(=O)NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,,C1COCCO1,ClCCl,,,val
US05679866,COc1cc(C)cc(OC)c1OC.O=C(Cl)c1c(Cl)cccc1Cl>>COc1cc(C)c(C(=O)c2c(Cl)cccc2Cl)c(O)c1OC,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20040132726A1,CCOC(=O)c1sccc1Cl.Clc1cccc(-c2nc(CN3CCNCC3)no2)c1>>CCSC(=O)N1CCN(Cc2noc(-c3cccc(Cl)c3)n2)CC1,,C1CCOC1,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20150238473A1,COC(=O)c1ccc(C2(CCCCl)SCCCS2)cc1.O=C(OI(OC(=O)C(F)(F)F)c1ccccc1)C(F)(F)F>>COC(=O)c1ccc(C(=O)CCCCl)cc1,,O,,CC#N,,val
US20060004025A1,CC#N.CCO.C[Si](C)(C)[N-][Si](C)(C)C.Cc1ccccc1N=C=S.[Na+]>>Cc1ccccc1-n1c([S-])c(C#N)ccc1=O.[Na+],,C1CCOC1,,,,val
US20160145247A1,COC(=O)Cc1ccccc1OCc1cc(Cl)cc(CO)c1>>COC(=O)Cc1ccccc1OCc1cc(Cl)cc(C=O)c1,,ClCCl,,CS(C)=O,O=C(Cl)C(=O)Cl,val
US20090149456A1,C=CS(C)(=O)=O.NCc1cccc([N+](=O)[O-])c1>>CS(=O)(=O)CCNCc1cccc([N+](=O)[O-])c1,,ClCCl,,Cl,[Na+].[OH-],val
US20160096827A1,CC(C)(O)c1ccc(Nc2ncnc(Cl)n2)cn1.C[C@H](O)C(=O)N1CC[C@H](Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2C#N)[C@H](F)C1>>C[C@H](O)C(=O)N1CC[C@H](Oc2ccc(-c3ncnc(Nc4ccc(C(C)(C)O)nc4)n3)cc2C#N)[C@H](F)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20090047244A1,CC1(S([NH-])(=O)=O)CC1.COc1ccc2c(OCC[C@@H]3NC(=O)N(C)CCCCC=C[C@@H]4C[C@@]4(C(=O)O)NC3=O)cc(-c3nc(C(C)C)cs3)nc2c1C>>COc1ccc2c(OCC[C@@H]3NC(=O)N(C)CCCCC=C[C@@H]4C[C@@]4(C(=O)NS(=O)(=O)C4(C)CC4)NC3=O)cc(-c3nc(C(C)C)cs3)nc2c1C,,C1CCOC1,,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20100087437A1,Nc1ccc(C(=O)N2CCOC(c3ccccc3)C2)cc1.O=Cc1ccccc1>>O=C(c1ccc(NCc2ccccc2)cc1)N1CCOC(c2ccccc2)C1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04322370,C=C1c2cc(OCCN(C)C)ccc2C(c2ccc(Cl)cc2)CC1(C)C.Cl>>CC1c2cc(OCCN(C)C)ccc2C(c2ccc(Cl)cc2)CC1(C)C.Cl,[Pd],CCO,,[H][H],,val
US06133261,NCc1ccccc1.N[C@H](CO)C(=O)O>>NC(CO)C(=O)NCc1ccccc1,,CO,,Cl,,val
US20090181964A1,BrCc1ccccc1.COc1c(C(=O)O)cccc1[N+](=O)[O-]>>COc1c(C(=O)OCc2ccccc2)cccc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100261728A1,COCCNc1ccc(F)cc1.O=C(n1ccnc1)n1ccnc1>>COCCN(C(=O)n1ccnc1)c1ccc(F)cc1,,C1CCOC1,,,,val
US20040132708A1,C=C(C)[C@H](C(=O)OCc1ccc([N+](=O)[O-])cc1)N1C(=O)[C@H](Br)[C@H]1SSc1nc2ccccc2s1>>CC(C)=C(C(=O)OCc1ccc([N+](=O)[O-])cc1)N1C(=O)[C@H](Br)[C@H]1SSc1nc2ccccc2s1,,Cc1ccccc1,,CCN(CC)CC,,val
US04939165,CC(C)(C)c1ccc(-c2ccc(-c3ccc(Br)s3)s2)cc1.CO>>COc1ccc(-c2ccc(-c3ccc(C)cc3)s2)s1,,C1CCOC1,CO,Cl,C[O-].[Na+],val
US20090312381A1,NNC(=O)c1cccc(Cl)c1.O=C=NC1CC1>>O=C(NNC(=O)c1cccc(Cl)c1)NC1CC1,,C1CCOC1,,,,val
US20120115894A1,CCOC(=O)[C@H]1C[C@@H]1c1ccc(-c2cn(CCF)cn2)cc1.O=C1CCC(=O)N1I>>CCOC(=O)[C@H]1C[C@@H]1c1ccc(-c2ncn(CCF)c2I)cc1,O=C(O)C(F)(F)F,ClCCl,,O=C([O-])O.[Na+],,val
US20030060627A1,CCCOc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1-c1nc2c([nH]1)c(=O)[nH]c(=O)n2CCC.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>CCCOc1ccccc1-c1nc2c([nH]1)c(S)nc(=O)n2CCC,,c1ccncc1,,,,val
US08609644B2,C[C@]12CC[C@H](O)CC1[C@@H](O)C[C@H]1[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]12.O=CO>>C[C@]12CC[C@@H](OC=O)CC1[C@@H](O)C[C@H]1[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]12,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050209217A1,COC(=O)[C@H](CCSC)NC(=O)c1cc([N+](=O)[O-])ccc1Cc1ccccc1>>CSCC[C@H](NC(=O)c1cc([N+](=O)[O-])ccc1Cc1ccccc1)C(=O)O,,CO,,[Na+].[OH-],,val
US20040157839A1,CC(=O)O.CCOC(C)=N.Nc1cc(-c2ccccc2Cl)n[nH]1>>CC(=N)Nc1cc(-c2ccccc2Cl)n[nH]1.CC(=O)O,,CC(=O)O,,CCOC(C)=O,,val
US04596819,Cc1ccc(C(=O)N[C@H](CSCC(=O)OC(C)(C)C)CC(C)C)s1>>Cc1ccc(C(=O)N[C@H](CSCC(=O)O)CC(C)C)s1,,O=C(O)C(F)(F)F,,,,val
US20070135452A1,Cc1ccc(O)c(C)c1.O=[N+]([O-])c1cccc2nc(Br)sc12>>Cc1ccc(Oc2nc3cccc([N+](=O)[O-])c3s2)c(C)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20120022057A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)[C@@H]1CCC[C@H]1C(=O)c1ccc(Br)cc1>>COC(=O)[C@@H]1CCC[C@H]1C(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1,,C1COCCO1,,ClCCl,CC(=O)[O-].[K+],val
US20060154977A1,CCCCCO.O=C1N=c2ccc(C(=O)O)cc2=N1>>CCCCC(=O)[O-].O=C1N=c2ccccc2=N1,,CCCCCO,,,,val
US20030032671A1,CC(C)c1ccc(NC(=O)CBr)c(C(F)(F)F)c1.COCCNCc1ccc(OC(C)(C)C(=O)OC(C)(C)C)cc1>>COCCN(CC(=O)Nc1ccc(C(C)C)cc1C(F)(F)F)Cc1ccc(OC(C)(C)C(=O)OC(C)(C)C)cc1,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20080004271A1,CCOC(=O)CC#N.N=C(N)N.O=Cc1cccc(OCc2ccccc2)c1>>N#Cc1c(O)nc(N)nc1-c1cccc(OCc2ccccc2)c1,,CCO,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090197859A1,CI.O=C(c1cccc(N2CCCNCC2)n1)N1CC[C@@H](Oc2ccccc2F)C1>>CN1CCCN(c2cccc(C(=O)N3CC[C@@H](Oc4ccccc4F)C3)n2)CC1,,C1CCOC1,,O,[H-].[Na+],val
US20080039456A1,O=CN1CCOCC1.O=[N+]([O-])c1ccc(-c2nccs2)cc1>>O=Cc1cnc(-c2ccc([N+](=O)[O-])cc2)s1,,CCOCC,,CCCCCC,[Li]CCCC,val
US20040106655A1,C1CNCCN1.O=[N+]([O-])c1ccccc1F>>O=[N+]([O-])c1ccccc1N1CCNCC1,,CN(C)C=O,,O,,val
US20120172351A1,COC(=O)C[C@@H]1COc2cc(N)ccc21.O=Cc1cccc(Br)c1O>>COC(=O)C[C@@H]1COc2cc(N=Cc3cccc(Br)c3O)ccc21,,Cc1ccccc1,,,,val
US05952325,OCCc1ccncc1.Oc1ccccc1I>>Ic1ccccc1OCCc1ccncc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20020151561A1,CC(C)(C)OC(=O)C(=O)n1ccnc1>>CC(C)(C)OC(=O)C(N)=O,,ClCCl,,CCN(CC)CC,,val
US05935966,CC(C)(C)[Si](C)(C)Cl.CCc1nc(SC)ncc1CO>>CCc1nc(SC)ncc1CO[Si](C)(C)C(C)(C)C,,CN(C)C=O,,c1c[nH]cn1,,val
US20100004239A1,Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCCCC1)CC2.O=C1Cc2cc(F)ccc2N1>>Cc1c(C=C2C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN1CCCCC1)CC2,,CCO,,C1CCNCC1,,val
US04874861,C[Si](C)(C)c1ccc(CBr)cc1.Cc1c(O)cnn(C(C)(C)C)c1=O>>Cc1c(OCc2ccc([Si](C)(C)C)cc2)cnn(C(C)(C)C)c1=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070066624A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.NC(CNC1CCOCC1)c1ccccc1>>CC(C)(C)OC(=O)N1CCC(NC(CNC2CCOCC2)c2ccccc2)CC1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150353573A1,CCOC(=O)C(F)(F)C1(O)O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1.O=S(Cl)Cl>>CCOC(=O)C(F)(F)C1(Cl)O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1,,ClCCl,,c1ccncc1,,val
US20110172230A1,CC(C)(C)OC(=O)N1CCNCC1.O=Cc1ccc(OCc2cccc(F)c2)cc1>>CC(C)(C)OC(=O)N1CCN(Cc2ccc(OCc3cccc(F)c3)cc2)CC1,,C1CCOC1,CC(=O)O,[Na+].[OH-],,val
US20130338152A1,Nc1ncnc2c1c(-c1cc(O)ccc1F)cn2[C@@H]1C[C@H](CN2CCS(=O)(=O)CC2)C1.OC[C@@H]1CCCO1>>Nc1ncnc2c1c(-c1cc(OC[C@@H]3CCCO3)ccc1F)cn2C1CC(CN2CCS(=O)(=O)CC2)C1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040102478A1,COC(=O)C(N)C(C(=O)OC)c1ccccc1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>COC(=O)C(NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(C(=O)OC)c1ccccc1,,ClCCl,,Cl,,val
US20160002242A1,Cc1ccc2cc(N)ccc2n1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>Cc1ccc2cc(Nc3nc(Cl)ncc3[N+](=O)[O-])ccc2n1.Cl,,C1CCOC1,,,,val
US20110098276A1,NOC1CCN(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)CC1.O=C=Nc1ccc(F)cc1>>O=C(NOC1CCN(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)CC1)Nc1ccc(F)cc1,,ClCCl,,c1ccncc1,,val
US20090209524A1,CCCCCN.Cc1cc(Cl)nc(N)n1>>CCCCCNc1cc(C)nc(N)n1,,C1COCCO1,,,,val
US20060235030A1,CCCN.CSc1nc(-c2cc(C(=O)O)ccc2C)c2c(n1)N(c1c(F)cccc1F)C(=O)NC2>>CCCNC(=O)c1ccc(C)c(-c2nc(SC)nc3c2CNC(=O)N3c2c(F)cccc2F)c1,,ClCCl,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070129544A1,N#Cc1cccc(N)c1.O=C=NC(=O)CCl>>N#Cc1cccc(N2CC(=O)NC2=O)c1,,C1COCCO1,,C1CCC2=NCCCN2CC1,,val
US20150175602A1,CC(=O)OC(C)=O.CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CNCC2.O=C(O)C(F)(F)F>>CC(=O)N1CCc2nc(NC(C)C)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1.O=C(O)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US20110257151A1,CC(C)[C@@H]1COC(=O)N1c1cccc(C2Nc3ccc(C(=O)O)cc3CC2(C)C)c1.NS(=O)(=O)C1CC1>>CC(C)[C@@H]1COC(=O)N1c1cccc(C2Nc3ccc(C(=O)NS(=O)(=O)C4CC4)cc3CC2(C)C)c1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20080318944A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CON(C)C(=O)C1CN(C)CCN1C(=O)OCc1ccccc1>>CON(C)C(=O)C1CN(C)CCN1C(=O)OC(C)(C)C,[Pd],CCOC(C)=O,,,,val
US20080188500A1,CC1(C)OB(c2ccc([N+](=O)[O-])cc2)OC1(C)C.Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1I>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccc([N+](=O)[O-])cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20070259898A1,O=C(CCC(NCc1cc(Oc2ccccc2)ncc1[N+](=O)[O-])C1CCCCC1)N(CCO)C1CCCCC1>>Nc1cnc(Oc2ccccc2)cc1CNC(CCC(=O)N(CCO)C1CCCCC1)C1CCCCC1,[Pd],CO,,,,val
US20080004309A1,CCOC(=O)c1nc(C#N)c2c(ccn2Cc2cccc(OC)c2)c1OC(C)=O.O=C1CCC(=O)N1Cl>>CCOC(=O)c1nc(C#N)c2c(c(Cl)cn2Cc2cccc(OC)c2)c1OC(C)=O,,CC#N,,,,val
US20090209597A1,O=Cc1cccc([N+](=O)[O-])c1>>O=[N+]([O-])c1cccc(CO)c1,,CO,,[BH4-].[Na+],,val
US20040039013A1,Cc1cccc(C)c1CCl.Cc1nc2c(N)cc(C(=O)OC(C)C)cn2c1C>>Cc1cccc(C)c1CNc1cc(C(=O)OC(C)C)cn2c(C)c(C)nc12,,CC(C)O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20150239842A1,CC(C)OC(=O)c1cc(-c2cnn(C)c2)ncc1Cl.O=C(OO)c1cccc(Cl)c1>>CC(C)OC(=O)c1cc(-c2cnn(C)c2)[n+]([O-])cc1Cl,,ClCCl,,,,val
US20140249146A1,CCN(C(C)C)C(C)C.CCOC(C)=O.CS(=O)(=O)Cl.ClCCl.O=C([O-])O.O=C1NCCn2cc(-c3cccc(OC(F)(F)F)c3)cc21>>CS(=O)(=O)NCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccccc3)n21,,CCOC(C)=O,ClCCl,Cl,,val
US05036064,CSc1ccc2c(c1)OC(C)(C)O2.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ccc2c(c1)OC(C)(C)O2,,ClCCl,,,,val
US20160000760A1,O=[N+]([O-])c1ccc(I)c(Cl)c1.OB(O)c1ccc(F)cc1>>O=[N+]([O-])c1ccc(-c2ccc(F)cc2)c(Cl)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20040122038A1,CCn1c(=O)c2ccc([N+](=O)[O-])cc2c2ccccc21>>CCn1c(=O)c2ccc(N)cc2c2ccccc21,[Pd],CCO,,,,val
US06251911B1,CC(C)(C)OC(=O)NCc1cccc(N)c1.CSC(SC)=C(C#N)C#N>>CSC(Nc1cccc(CNC(=O)OC(C)(C)C)c1)=C(C#N)C#N,,CO,,,,val
US20110275797A1,CO.COc1cc(C(=O)O)c(N)cc1-c1ccccc1>>COC(=O)c1cc(OC)c(-c2ccccc2)cc1N,,ClC(Cl)Cl,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20060178377A1,CC(=O)c1cn2c(-c3ccc(Cl)cc3Cl)c(CNC(=O)OC(C)(C)C)c(C)nc2n1>>Cc1nc2nc(C(C)O)cn2c(-c2ccc(Cl)cc2Cl)c1CNC(=O)OC(C)(C)C,,C1CCOC1,O,[BH4-].[Na+],,val
US06180629B2,Nn1nc(-c2ccccn2)c2c(F)ccc(F)c2c1=O.O=C(Cl)c1ccccc1>>O=C(Nn1nc(-c2ccccn2)c2c(F)ccc(F)c2c1=O)c1ccccc1,,ClCCl,,,,val
US20020103211A1,CC(=O)O[C@H](C)CCCCn1c(=O)c2c(ncn2Cc2ccccc2)n(C)c1=O>>CC(=O)O[C@H](C)CCCCn1c(=O)c2[nH]cnc2n(C)c1=O,[Pd],CC(=O)O,,[H][H],,val
US20090311217A1,CN1CCNCC1.COc1ccc2[nH]c(C(=O)O)cc2c1>>COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1,,ClCCl,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20040176367A1,CCCCc1nc2cnc3ccccc3c2n1N=C(C)C>>CCCCc1nc2cnc3ccccc3c2n1NC(C)C,,CO,,[BH4-].[Na+],,val
US20140155391A1,CC(C)(C)OC(=O)N(Cc1ccc(C(=O)O)cc1OCC1CC1)S(C)(=O)=O.[O-][n+]1cc(Cl)c(C[C@H](O)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1>>CC(C)(C)OC(=O)N(Cc1ccc(C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)cc1OCC1CC1)S(C)(=O)=O,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US04816445,OC[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>OC[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O,,CC(C)O,,,,val
US20140323468A1,CC(=O)c1cncc(-c2cnc3c(c2)CCCN3)c1.O=C=NC(=O)c1ccccc1>>CC(=O)c1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1,,ClCCl,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20080194647A1,N#Cc1cncc(C#Cc2ccc(F)c(CO)c2)c1.O=S(Cl)Cl>>N#Cc1cncc(C#Cc2ccc(F)c(CCl)c2)c1,,CCOC(C)=O,,,,val
US20110212025A1,CCN(CC)C(=O)Cc1c(-c2ccc(O)c(I)c2)nn2c(C)cc(C)nc12.CI>>CCN(CC)C(=O)Cc1c(-c2ccc(OC)c(I)c2)nn2c(C)cc(C)nc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110263584A1,CC(C)n1cc(Br)cn1.C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O>>C[C@@H](c1ccc(-c2cnn(C3CC3)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US04364875,Cc1cc(Cl)c(Sc2ccc([N+](=O)[O-])c(Oc3ccccc3)c2Cl)cc1Cl.NCc1ccccc1>>Cc1cc(Cl)c(Sc2ccc([N+](=O)[O-])c(NCc3ccccc3)c2Cl)cc1Cl,,C1COCCO1,,,,val
US20110218193A1,CCOC(=O)c1ccc2[nH]c(=O)c3c(c2c1)NCCC3.Cl>>CCOC(=O)c1ccc2[nH]c(=O)c3c(c2c1)NCCC3.Cl,,C1COCCO1,,,,val
US04734123,CC(=O)Nc1nc(S(=O)(=O)Nc2c(Cl)cccc2Cl)n[nH]1>>Nc1nc(S(=O)(=O)Nc2c(Cl)cccc2Cl)n[nH]1,,C1CCOC1,,Cl,,val
US20100093694A1,CC(=O)Cl.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cccc(C(=O)NC(C)(C)c4ccccc4)c3)c(N)c12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cccc(C(=O)NC(C)(C)c4ccccc4)c3)c(NC(C)=O)c12,,c1ccncc1,,,,val
US20110118245A1,COCCOc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC.Cn1nc(C(C)(C)C)cc1NC(=O)Oc1ccccc1>>COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C)nn4C)c3)c2cc1OC,CN(C)c1ccncc1,,,CCN(C(C)C)C(C)C,,val
US04775671,CN1Cc2c(C(=O)n3ccnc3)ncn2-c2ccc(F)cc2C1=O.NC(=NO)C1CC1>>CN1Cc2c(-c3nc(C4CC4)no3)ncn2-c2ccc(F)cc2C1=O,,CN(C)C=O,,,,val
US20010037036A1,CCCCOc1ccc(C(C)(C)C)cc1C(O)(c1cc(C(C)(C)C)ccc1OCCCC)[C@@H](C)N.O=Cc1ccccc1O>>CCCCOc1ccc(C(C)(C)C)cc1C(O)(c1cc(C(C)(C)C)ccc1OCCCC)[C@@H](C)N=Cc1ccccc1O,,CCO,Cc1ccccc1,,,val
US20080153812A1,C1CC2CNCCN2C1.COc1cc(COc2cc(NC(=O)c3cnc(Cl)cn3)[nH]n2)cc(OC)c1>>COc1cc(COc2cc(NC(=O)c3cnc(N4CCN5CCCC5C4)cn3)[nH]n2)cc(OC)c1,,CS(C)=O,,,,val
US20140296136A1,C1COCCN1.COC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)O[C@@H]1C[C@H]1CCCCCc1c(nc3ccccc3c1C=O)O2>>COC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)O[C@@H]1C[C@H]1CCCCCc1c(nc3ccccc3c1CN1CCOCC1)O2,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120083474A1,N#Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(N2CCCC2)c1>>NCc1cc(-c2ccc(C(F)(F)F)cc2)nc(N2CCCC2)c1,[Pd],CCO,,Cl,,val
US20130079328A1,Cn1cc(-c2ccc(CNC(=O)OC(C)(C)C)cc2F)ccc1=O>>Cn1cc(-c2ccc(CN)cc2F)ccc1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110152237A1,COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc(-c3ccc(C(=O)CN(C(=O)[O-])C(C)(C)C)cc3)cc2)c[nH]1)C(C)C>>COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc(-c3ccc(C(=O)CN)cc3)cc2)c[nH]1)C(C)C,,ClCCl,,Cl,,val
US20090209607A1,CCc1sc(C(=O)OC)cc1-c1ccnn1C.O=C1CCC(=O)N1Br>>CCc1sc(C(=O)O)cc1-c1c(Br)cnn1C,,C1CCOC1,,[Na+].[OH-],,val
US20070054935A1,COc1ccccc1[Mg]Br.N#Cc1cccc(-c2ccncc2C=O)c1>>COc1ccccc1C(O)c1cnccc1-c1cccc(C#N)c1,,C1CCOC1,,,,val
US20110015175A1,COc1cc(N)ccc1-n1cnc(Cl)n1.O=c1ccccn1C(=S)n1ccccc1=O>>COc1cc(N=C=S)ccc1-n1cnc(Cl)n1,,ClCCl,,,,val
US20050065340A1,COC(=O)c1ccc(O)c(OC)c1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1ccc(OS(=O)(=O)C(F)(F)F)c(OC)c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080275116A1,CI.COC(=O)C(=O)Nc1cc(-c2ccc(OC(F)(F)F)cc2)ccc1OCc1ccc(C(C)(C)C)cc1>>COC(=O)C(=O)N(C)c1cc(-c2ccc(OC(F)(F)F)cc2)ccc1OCc1ccc(C(C)(C)C)cc1,,CC#N,O,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US06429315B1,CC[C@H](Cc1sccc1Cl)NS(=O)(=O)c1ccc(C)cc1.O=[N+]([O-])c1c(F)ccnc1F>>Cc1ccc(S(=O)(=O)Nc2ccnc(F)c2[N+](=O)[O-])cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20120283273A1,COCc1ncnc(Cl)c1C>>Cc1c(Cl)ncnc1CO,,ClCCl,,BrB(Br)Br,,val
US20120022045A1,Cc1nnc(C(=O)N(C)C23CCC(Cn4c2nc(C(=O)NCc2ccc(F)cc2)c(OS(C)(=O)=O)c4=O)C3)o1>>Cc1nnc(C(=O)N(C)C23CCC(Cn4c2nc(C(=O)NCc2ccc(F)cc2)c(O)c4=O)C3)o1,,CC(C)O,,[Na+].[OH-],,val
US20090306057A1,NCc1csc2c1S(=O)(=O)N=C(C1=C(O)[C@@H]3[C@H]4CC[C@H](C4)[C@@H]3N(Cc3ccc(F)cc3)C1=O)N2.O=S(=O)(Cl)C1CC1>>O=C1C(C2=NS(=O)(=O)c3c(CNS(=O)(=O)C4CC4)csc3N2)=C(O)[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2N1Cc1ccc(F)cc1,,ClCCl,,CCN(CC)CC,,val
US20050009804A1,COC(=O)c1sc(-c2ccccc2)cc1N(C(=O)C1CCC(C)CC1)C1CCC(O)CC1.O=C(O)c1ccc([N+](=O)[O-])cc1>>COC(=O)c1sc(-c2ccccc2)cc1N(C(=O)C1CCC(C)CC1)C1CCC(OC(=O)c2ccc([N+](=O)[O-])cc2)CC1,,c1ccccc1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04636516,C=O.CC(C)(C)c1cc(-c2cn3c(n2)SCC3)cc(C(C)(C)C)c1O.CNC>>CN(C)Cc1c(-c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)nc2n1CCS2,,C1COCCO1,,CC(=O)O,,val
US20060122185A1,BrBr.CC(=O)c1n[nH]c2ncccc12>>O=C(CBr)c1n[nH]c2ncccc12,,Br,,,,val
US20020049222A1,CC(C)C1(C(=O)O)CCC(=O)C1.O=S(Cl)Cl>>CC(C)C1(C(=O)Cl)CCC(=O)C1,,c1ccccc1,,,,val
US20130203995A1,CCOC(=O)c1coc(C=O)c1.Cl.NCc1ccc(OC(F)(F)F)cc1>>CCOC(=O)c1coc(CNCc2ccc(OC(F)(F)F)cc2)c1.Cl,,CCO,Cc1ccccc1,[BH4-].[Na+],,val
US20050026976A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=C1NCc2c(Br)cccc21>>CC1(C)OB(c2cccc3c2CNC3=O)OC1(C)C,,CN(C)C=O,,ClCCl,CC(=O)[O-].[K+],val
US20020065270A1,CC(C)(C)OC(=O)N1CC(N=[N+]=[N-])CC1C(C)(C)O[SiH2]C(C)(C)C>>CC(C)(C)OC(=O)N1CC(N)CC1C(C)(C)O[SiH2]C(C)(C)C,,CCOC(C)=O,,,,val
US20160221998A1,Nc1cc(Br)ccn1.OB(O)c1ccsc1>>Nc1cc(-c2ccsc2)ccn1,,O,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US05656573,CCOC=C(C(=O)c1ccc(SC)cc1OC)C(=O)C1CC1.NO>>COc1cc(SC)ccc1C(=O)c1cnoc1C1CC1,,CCO,,Cl,CC(=O)[O-].[Na+],val
US20150072980A1,COc1cc2c(cc1N1CCOCC1)C/C(=C\c1cc(C(F)(F)F)ccc1F)C2=O>>COc1cc2c(cc1N1CCOCC1)CC(Cc1cc(C(F)(F)F)ccc1F)C2=O,[Pd],CO,,,,val
US09221834B2,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(N2CC(F)(F)C2)ncc1Br>>C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(N2CC(F)(F)C2)ncc1B1OC(C)(C)C(C)(C)O1,,CS(C)=O,,C1COCCO1,CC(=O)[O-].[K+],val
US20020119963A1,O=C(O)Cc1ccc2ncccc2c1.O=[N+]([O-])c1cn(C2CCC2)cn1>>O=C(Cc1ccc2ncccc2c1)Nc1cn(C2CCC2)cn1,[Pd],ClCCl,,CCN(CC)CC,CCOC(C)=O,val
US20050107449A1,COC(=O)C=Cc1ccc(CO)cc1C>>COC(=O)CCc1ccc(CO)cc1C,[Ni],C1CCOC1,,[H][H],,val
US20110105488A1,C1CCNCC1.CC(Br)C(N)=O>>NC(=O)CCN1CCCCC1,,CO,,,,val
US20040248854A1,C=COCC.O=C1CCC[C@H](CO)N1>>CCOC(C)OC[C@H]1CCCC(=O)N1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20100331306A1,CC(NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2cc1-c1ccccn1>>CC(N)c1nc2ccc(F)cc2cc1-c1ccccn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100310512A1,CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)[nH]1.Cl>>CC1(C)OB(c2ccc(-c3cnc([C@@H]4CCCN4)[nH]3)cc2)OC1(C)C.Cl,,C1COCCO1,ClCCl,CCOCC,,val
US06187777B1,CNCCNC.Cc1nc(Cl)c2nc(-c3ccccc3)cc-2[nH]1>>CNCCN(C)c1nc(C)[nH]c2cc(-c3ccccc3)nc1-2,,O,,O=C([O-])[O-].[K+].[K+],,val
US20070179115A1,CC(C)(C)OC(=O)NCc1ccc(-c2cccc(O)c2)cc1.CCCBr>>CCCOc1cccc(-c2ccc(CNC(=O)OC(C)(C)C)cc2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050282858A1,COCN(Cc1ccccc1)C[Si](C)(C)C.O=c1ccc2ccccc2o1>>O=C1Oc2ccccc2C2CN(Cc3ccccc3)CC12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140315894A1,COc1ccc(C2=NN(c3ccccc3)C(=O)C2)cc1.N#CCC#N.O=Cc1ccc(F)cc1>>COc1ccc(-c2nn(-c3ccccc3)c3c2C(c2ccc(F)cc2)C(C#N)=C(N)O3)cc1,,CCO,,CCN(CC)CC,,val
US20100150866A1,C=CCCCCCC1(S(=O)(=O)NC(=O)OC(C)(C)C)CC1>>C=CCCCCCC1(S(N)(=O)=O)CC1,,O,,C1COCCO1,Cl,val
US20100292207A1,CN1CCN(c2ccc(C(=O)Nc3nn(C(c4ccccc4)(c4ccccc4)c4ccccc4)c4ccc(Cc5cc(F)cc(F)c5)cc34)c([N+](=O)[O-])c2)CC1>>CN1CCN(c2ccc(C(=O)Nc3nn(C(c4ccccc4)(c4ccccc4)c4ccccc4)c4ccc(Cc5cc(F)cc(F)c5)cc34)c(N)c2)CC1,[Pd],CO,,O=C[O-].[NH4+],,val
US20040122244A1,CC(=O)Oc1ccc(CC2=C(C)C(=O)C(C)=C(C)C2=O)cc1C(=O)O.Nc1ccc(C(F)(F)F)cc1>>CC(=O)Oc1ccc(CC2=C(C)C(=O)C(C)=C(C)C2=O)cc1C(=O)Nc1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US06313126B1,Cn1cc(C2CCC(=O)CC2)c2cc(C#N)ccc21.c1cc(N2CCNCC2)c2cc[nH]c2c1>>Cn1cc(C2CCC(N3CCN(c4cccc5[nH]ccc45)CC3)CC2)c2cc(C#N)ccc21,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20050101587A9,CC(=O)N1CCc2[nH]nc(-c3ccc(Br)cc3)c2C1.ClCC1CO1>>CC(=O)N1CCc2c(c(-c3ccc(Br)cc3)nn2CC2CO2)C1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130005771A1,COc1ccc(C=CC(=O)O)cc1OC.N=C(NO)C1CCCCC1>>COc1ccc(C=Cc2nc(C3CCCCC3)no2)cc1OC,,Cc1ccccc1,,,,val
US20100286145A1,CCCC[Sn](CCCC)(CCCC)c1cnccn1.COC(=O)c1cc(Br)cc(C(=O)OC)c1>>COC(=O)c1cc(C(=O)OC)cc(-c2cnccn2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20120101103A1,Clc1ccnc(Cl)n1.OB(O)c1ccc(C(F)(F)F)cc1>>FC(F)(F)c1ccc(-c2ccnc(Cl)n2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20060189606A1,N#CCC(=O)OCc1ccccc1.Nc1ccc(OC(F)(F)F)cc1[N+](=O)[O-]>>FC(F)(F)Oc1ccc2cc[nH]c2c1,,CC#N,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04081440,CC1(C)C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)[C@@H](NC(=O)Cc3ccccc3)[C@H]2S1=O.O=C1CCC(=O)N1Cl>>C=C(C)C(C(=O)OCC(Cl)(Cl)Cl)N1C(=O)C(NC(=O)Cc2ccccc2)C1S(=O)Cl,,Cc1ccccc1,,,,val
US20040058970A1,CC(C)(C)OC(=O)Nc1ccc2c(c1)C(=O)NC2.COS(=O)(=O)C(F)(F)F>>COC1=[NH+]Cc2ccc(NC(=O)OC(C)(C)C)cc21.O=S(=O)([O-])C(F)(F)F,,ClCCl,,,,val
US20160120850A1,C[Si](C)(C)CCOCOCc1csc(C(N)=O)n1>>C[Si](C)(C)CCOCOCc1csc(C#N)n1,,ClCCl,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US06395733B1,Clc1ncnc2ncccc12.Nc1ccccc1>>c1ccc(Nc2ncnc3ncccc23)cc1,,O,,[NH4+].[OH-],,val
US20100137281A1,N#Cc1ccccc1-c1ccc(CBr)cc1.O=c1[nH]c2sccc2c(=O)n1CCc1ccccc1>>N#Cc1ccccc1-c1ccc(Cn2c(=O)n(CCc3ccccc3)c(=O)c3ccsc32)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05985900,CC(C)(C)OC(=O)CN([C@@H](C(=O)O)C(C)(C)S)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1>>CC(C)(SCC(=O)O)[C@@H](NS(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060252751A1,Clc1nc2ccccc2s1.NCC(=O)N[C@@H]1CCN(C2CCC(O)(c3ccccn3)CC2)C1>>O=C(CNc1nc2ccccc2s1)N[C@@H]1CCN(C2CCC(O)(c3ccccn3)CC2)C1,,CC(C)O,,CCN(CC)CC,,val
US20020040040A1,CC(=O)OCC(=O)Nc1cc(-c2ccccc2C)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1>>Cc1ccccc1-c1cc(NC(=O)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,C1CCOC1,,CCOC(C)=O,[Na+].[OH-],val
US05852014,COC(=O)c1c(N)[nH]c2ccccc12.COC(CC(OC)OC)OC>>COC(=O)c1c2ccccc2n2cccnc12,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150218141A1,O=C=Nc1ccc(F)c(Cl)c1.O[C@@H](CN1CCCC(c2cccc(C(F)(F)F)c2)C1)C(F)(F)F>>O=C(Nc1ccc(F)c(Cl)c1)O[C@@H](CN1CCCC(c2cccc(C(F)(F)F)c2)C1)C(F)(F)F,,ClCCl,,,,val
US20020025910A1,CS(=O)(=O)c1ccc(C(=O)O)c(Cl)c1C1=NOCC1.O=S(Cl)Cl>>CS(=O)(=O)c1ccc(C(=O)Cl)c(Cl)c1C1=NOCC1,,Cc1ccccc1,,CN(C)C=O,,val
US20160009744A1,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cc1sc(C(=O)c2cncnc2N[C@H]2C[C@H](O)[C@@H](CO[Si](C)(C)C(C)(C)C)C2)cc1[C@@H]1OCCc2ccc(Cl)cc21>>Cc1sc(C(=O)c2cncnc2N[C@@H]2C[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](OC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C2)cc1[C@@H]1OCCc2ccc(Cl)cc21,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20150152083A1,Cc1ccc2c(c1)nc(N)n2-c1cccc(NC(=O)OC(C)(C)C)c1.O=C(O)c1ccc(F)cc1>>Cc1ccc2c(c1)nc(NC(=O)c1ccc(F)cc1)n2-c1cccc(NC(=O)OC(C)(C)C)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160095844A1,CC1(C)C(=O)Nc2cc(C(=O)NN)ccc21.O=C(O)C1(C(F)(F)F)CC1>>CC1(C)C(=O)Nc2cc(C(=O)NNC(=O)C3(C(F)(F)F)CC3)ccc21,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20070264299A1,CNC(=O)c1cc(I)cc(C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl.N#C[Cu]>>CNC(=O)c1cc(C#N)cc(C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl,[Cu]I,C1CCOC1,CCOC(C)=O,,,val
US20120329775A1,CC(C)(C)OC(=O)NC1(C(=O)N[C@@H](Cc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)C(N)=O)CCOCC1.CCS(=O)(=O)c1ccc(-c2ccc(C[C@H](NC(=O)C3(NC(=O)OC(C)(C)C)CCOCC3)C(N)=O)cc2)cc1>>CCS(=O)(=O)c1ccc(-c2ccc(C[C@@H](C#N)NC(=O)C3(NC(=O)OC(C)(C)C)CCOCC3)cc2)cc1,,ClCCl,,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US05196439,Cl.O=C(CBr)c1ccc2ccccc2c1.O=[N+]([O-])c1cccc(OC2CCNCC2)c1>>Cl.O=C(CN1CCC(Oc2cccc([N+](=O)[O-])c2)CC1)c1ccc2ccccc2c1,,CCO,,CCN(CC)CC,Cl,val
US20100093999A1,CC(C)(C)OC(=O)NC1=N[C@@]2(c3cc(Br)ccc3F)CO[C@@H](CO)C[C@H]2CS1.COCCN(CCOC)S(F)(F)F>>CC(C)(C)OC(=O)NC1=N[C@@]2(c3cc(Br)ccc3F)CO[C@@H](CF)C[C@H]2CS1,,ClCCl,,O=C([O-])O.[Na+],,val
US20150329548A1,C[C@@H]1CC[C@@H](Cn2cc(C(O)c3cccnc3)c3nc(Cl)nc(-c4cncc(Cl)c4)c32)CC1>>C[C@@H]1CC[C@@H](Cn2cc(Cc3cccnc3)c3nc(Cl)nc(-c4cncc(Cl)c4)c32)CC1,,ClCCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20150291563A1,NNc1ccccc1Cl.O=C(C=Cc1cccc(Br)n1)C(F)(F)C(F)(F)F>>FC(F)(F)C(F)(F)C1=NN(c2ccccc2Cl)C(c2cccc(Br)n2)C1,,CCO,,C1CCNCC1,Cl,val
US20120027874A1,CN(Cc1ccc(CO)c(F)c1)C(=O)OC(C)(C)C>>CN(Cc1ccc(C=O)c(F)c1)C(=O)OC(C)(C)C,O=[Mn]=O,ClCCl,,,,val
US20080058314A1,CCCCCCCOc1ccccc1C=CC(CCCCC(=O)O)Cc1ccc(C(=O)O)cc1>>CCCCCCCOc1ccccc1CCC(CCCCC(=O)O)Cc1ccc(C(=O)O)cc1,[Pd],CCOC(C)=O,,[H][H],,val
US08691822B2,CC(C)(C)OC(=O)N1CCN(C[C@@H]2CO2)CC1.N>>CC(C)(C)OC(=O)N1CCN(C[C@@H](O)CN)CC1,,CCO,,,,val
US20080021012A1,CC(=O)c1ccc(Br)cn1.CC1(C)OB(c2ccc(N3C[C@H](Cn4ccnn4)OC3=O)cc2F)OC1(C)C>>CC(=O)c1ccc(-c2ccc(N3C[C@H](Cn4ccnn4)OC3=O)cc2F)cn1,,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20050130923A1,COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.O=c1ccn([C@@H]2S[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1>>COc1ccc(C(c2ccccc2)(c2ccc(OC)cc2)C(O)[C@H]2S[C@@H](n3ccc(=O)[nH]c3=O)[C@H](O)[C@@H]2O)cc1,,c1ccncc1,,,,val
US20120122895A1,CC(C)(C)OC(=O)n1ccc2c(Cn3ccc4c([N+](=O)[O-])cccc43)ccnc21>>CC(C)(C)OC(=O)n1ccc2c(Cn3ccc4c(N)cccc43)ccnc21,[Pd],C1CCOC1,,,,val
US20150218165A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CNc1ccc(F)cc1Br>>CNc1ccc(F)cc1B1OC(C)(C)C(C)(C)O1,,COCCOC,,CC(=O)[O-].[K+],,val
US20150320757A1,CC(C)(C)OC(=O)NC(=NCCN)NC(=O)OC(C)(C)C.O=C(O)c1ccc(Nc2nc(NC3(c4ccc(Cl)cc4)CC3)nc(OCC(F)(F)F)n2)cc1>>N=C1NCCN1C(=O)c1ccc(Nc2nc(NC3(c4ccc(Cl)cc4)CC3)nc(OCC(F)(F)F)n2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20050038035A1,CC(C)(C)OC(=O)Nc1nc(CCO)cs1.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)Nc1nc(CCOc2ccc([N+](=O)[O-])cc2)cs1,,C1CCOC1,,O,CC(C)(C)[O-].[K+],val
US20100249091A1,CCOC(CNC1=NC[C@@H](O[Si](C)(C)C(C)(C)C)C1)OCC>>O[C@H]1Cc2nccn2C1,,C1COCCO1,,Cl,,val
US20150005289A1,CC(C)(C)OC(=O)N1CCC(c2ccc(N)nc2)CC1.O=C([O-])C(C(=O)[O-])(c1c(Cl)cc(Cl)cc1Cl)c1c(Cl)cc(Cl)cc1Cl>>CC(C)(C)OC(=O)N1CCC(c2ccc3nc(O)cc(=O)n3c2)CC1,,C1CCOC1,,,,val
US04548940,Cc1ccc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)cn1.NCCCNc1ncc(Cl)cc1Cl>>Cc1ccc(Cc2cnc(NCCCNc3ncc(Cl)cc3Cl)[nH]c2=O)cn1,,O,,,,val
US03974289,CCc1ccc2oc(=O)cc(O)c2c1.O=[N+]([O-])O>>CCc1ccc2oc(=O)c([N+](=O)[O-])c(O)c2c1,,ClC(Cl)Cl,,,,val
US20090124671A1,CC1CC(O)(c2ncccc2Cl)CCC12OCCO2.CCN(CC)S(F)(F)F>>CC1CC(F)(c2ncccc2Cl)CCC12OCCO2,,ClCCl,,,,val
US04458078,CC(C)COC(=O)Cl.C[C@@H](N)C(=O)O.C[C@@H](N)C(=O)O[Si](C)(C)C.C[Si](C)(C)C(C(N)=O)[Si](C)(C)C.ClCCl>>NCC(=O)O.N[C@@H](CCC[C@@H](N)C(=O)O)C(=O)O,,CN(C)C=O,ClCCl,,,val
US20100317568A1,O=C(CCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1)c1ccc(Br)cc1>>O=[N+]([O-])c1cc(C(O)CCC(O)c2ccc(Br)cc2)ccc1Cl,,CCO,,[BH4-].[Na+],,val
US20160016948A1,CCOC(=O)C(C)(CNc1nccc(Nc2cc3c(cn2)nc(C)n3C(C)C)n1)COC(=O)C(C)(C)C>>Cc1nc2cnc(Nc3ccnc(NCC(C)(CO)C(=O)O)n3)cc2n1C(C)C,,Cl,,,,val
US20130029963A1,COCc1ccc(-c2cnnc(S(C)(=O)=O)n2)cc1.N>>COCc1ccc(-c2cnnc(N)n2)cc1,,C1CCOC1,,,,val
US20150225409A1,O=C(O[C@H]1C[C@H]2CN(c3ccc(C(F)(F)F)cn3)CCC(=O)N2C1)c1ccc([N+](=O)[O-])cc1>>O=C1CCN(c2ccc(C(F)(F)F)cn2)C[C@@H]2C[C@H](O)CN12,,CO,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20090270361A1,Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1C(=O)O.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1N,,Cc1ccccc1,,CCN(CC)CC,O,val
US20090029958A1,CCN(C(C)C)C(C)C.CCOC(C)=O.COC(=O)C1(CN=[N+]=[N-])CCNCC1.ClCCl.O=S(=O)(OCCOCCc1ccccc1)C(F)(F)F>>CCCC(C)C.CO.COC(=O)C1(CN=[N+]=[N-])CCN(CCOCCc2ccccc2)CC1.N,,CCOC(C)=O,ClCCl,,,val
US20140323485A1,Nc1[nH]ncc1-c1ccccn1.Nc1nc(C(F)(F)F)c(Br)nc1C(=O)O>>Nc1nc(C(F)(F)F)c(Br)nc1C(=O)Nc1[nH]ncc1-c1ccccn1,,CN(C)C=O,O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150225412A1,C[C@H](N(Cc1ccc(NC2CCCN(C(=O)OC(C)(C)C)C2)c(N)c1)C(=O)OCc1ccccc1)C(C)(C)C.N#CBr>>C[C@H](N(Cc1ccc2c(c1)[nH]c(=N)n2C1CCCN(C(=O)OC(C)(C)C)C1)C(=O)OCc1ccccc1)C(C)(C)C,,CCO,,,,val
US20020040043A1,N#Cc1ccc(CCOc2cccc(N)c2)cc1.O=S(=O)(Cl)c1ccccc1Cl>>N#Cc1ccc(CCOc2cccc(NS(=O)(=O)c3ccccc3Cl)c2)cc1,,ClCCl,,c1ccncc1,,val
US20030102800A1,CC(C)(C)C(=O)/C=C(\O)C(C)(C)C.CC(C)(C)C(=O)/C=C(\O)C(C)(C)C.CC(C)(C)C(=O)/C=C(\O)C(C)(C)C.CS(C)=O.[Tb]>>CC(C)(C)C(=O)/C=C(\O)C(C)(C)C.CC(C)(C)C(=O)/C=C(\O)C(C)(C)C.CC(C)(C)C(=O)/C=C(\O)C(C)(C)C.CS(C)=O.[Tb],,CC#N,ClCCl,,,val
US20110306602A1,CS(=O)(=O)c1cccc(Nc2cc(-c3ccccc3OCc3ccccc3)ncn2)c1>>CS(=O)(=O)c1cccc(Nc2cc(-c3ccccc3O)ncn2)c1,,O=C(O)C(F)(F)F,,,,val
US20070155753A1,CCOC(=O)C1CC2(CC(CC)N1S(=O)(=O)c1ccc(Cl)cc1)OCCO2>>CCC1CC2(CC(CO)N1S(=O)(=O)c1ccc(Cl)cc1)OCCO2,,C1CCOC1,,[BH4-].[Li+],,val
US20090143361A1,BrCC1CC1.Cc1nc(Br)n2c1c(C)nc1ccc(=O)[nH]c12>>Cc1nc(Br)n2c1c(C)nc1ccc(OCC3CC3)nc12,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US04731382,COC(=O)CCCCCCCCCCCC(=O)[O-].O=S(Cl)Cl>>COC(=O)CCCCCCCCCCCC(=O)Cl,,ClCCl,,,,val
US06825201B2,CNC(=O)c1ccc(F)c2c(C(=O)C(=O)N3CCN(C(=O)c4ccccc4)CC3)c[nH]c12>>CNC(=O)c1ccc(F)c2c(C(O)C(=O)N3CCN(C(=O)c4ccccc4)CC3)c[nH]c12,,CCO,,[BH4-].[Na+],,val
US06660408B1,Brc1ccc(-c2cccc3ccccc23)c2ccccc12.O=C1c2ccccc2Cc2ccccc21>>c1ccc2c(-c3ccc(-c4c5ccccc5cc5ccccc45)c4ccccc34)cccc2c1,,C1CCOC1,CCOCC,Cl,[Mg],val
US20140005213A1,CI.Cc1ccc2ccc(OC[C@@H](C)O)cc2n1>>CO[C@H](C)COc1ccc2ccc(C)nc2c1,,CN(C)C=O,,[H-].[Na+],,val
US20150305332A1,CO.O=C(O)c1ccc2sccc2c1>>COC(=O)c1ccc2sccc2c1,,CO,,O=C(Cl)C(=O)Cl,,val
US04788195,CN(C)CCCl.Oc1ccc(Nc2nccc(-c3cccnc3)n2)cc1>>CN(C)CCOc1ccc(Nc2nccc(-c3cccnc3)n2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100121048A1,CCN=C=NCCCN(C)C.Cc1cc(C(=O)N2CCN(Cc3ccccc3)CC2CCN(C(=O)CCC(=O)O)C(C)C)c(-c2ccccc2)n1-c1ccccc1>>Cc1cc(C(=O)N2CCN(Cc3ccccc3)CC2CCN(C(=O)CCC(N)=O)C(C)C)c(-c2ccccc2)n1-c1ccccc1,,CN(C)C=O,,Cl,O=C([O-])O.[Na+],val
US20070185153A1,BrP(Br)Br.COc1ccc(CO)cc1>>COc1ccc(CBr)cc1,,CCOCC,,,,val
US20130172360A1,CCOC(=O)c1cc(C#N)c(SC)nc1O>>CSc1nc(O)c(C(=O)O)cc1C#N,,CCO,O,[Li+].[OH-],,val
US20030232848A1,CC(=O)OCCBr.Cc1ccc(-c2c(O)nn(C)c2N)cc1>>CC(=O)OCCOc1nn(C)c(N)c1-c1ccc(C)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20030232812A1,CC(=O)NC[C@H]1CN(c2ccc(N3CCS(=O)CC3)c(F)c2)C(=O)O1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(=O)NC[C@H]1CN(c2ccc(N3C=CS(=O)(=O)CC3)c(F)c2)C(=O)O1,,ClCCl,,CN1CCOCC1,,val
US20020006948A1,COC(=O)CCCCCBr.O=S(=O)(Nc1ccc2c(c1)nc(-c1ccccc1)n2-c1ccccc1)c1ccc(C(F)(F)F)cc1>>COC(=O)CCCCCN(c1ccc2c(c1)nc(-c1ccccc1)n2-c1ccccc1)S(=O)(=O)c1ccc(C(F)(F)F)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20040116698A1,Cn1c(=O)c(Oc2ccccc2F)cc2cnc(S(C)(=O)=O)nc21.NCCO>>Cn1c(=O)c(Oc2ccccc2F)cc2cnc(NCCO)nc21,,ClC(Cl)Cl,,,,val
US20100152213A1,Cc1cccc(C(=O)O)c1N.S=C=Nc1ccccc1>>Cc1cccc2c(=O)n(-c3ccccc3)c(S)nc12,,CCO,,,,val
US20020016328A1,CCC(CO)Nc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCC(CN=[N+]=[N-])Nc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C,,Cc1ccccc1,,,,val
US03974141,O=C(Cl)c1ccccc1.O=C1NCCN1>>O=C1NCCN1C(=O)c1ccccc1,,ClC(Cl)Cl,,C1CCOC1,O=C([O-])O.[Na+],val
US04629493,COC(=O)C(C)Oc1ccc(O)cc1.Clc1ccc2nc(Cl)cnc2c1>>COC(=O)C(C)Oc1ccc(Oc2cnc3cc(Cl)ccc3n2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20160207905A1,Clc1ncc(Cl)c(Cl)n1.Nc1cccc([N+](=O)[O-])c1>>O=[N+]([O-])c1cccc(Nc2nc(Cl)ncc2Cl)c1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20030077264A1,C=CCSSCC=C.OO>>C=CCSS(=O)CC=C,,CC(=O)O,,O,,val
US20070244173A1,COCCO.Cc1nc2c3c(ccc2n1C1CC1)[C@@H](O)[C@H](O)[C@@H](c1ccccc1)O3>>COCCO[C@@H]1c2ccc3c(nc(C)n3C3CC3)c2O[C@H](c2ccccc2)[C@H]1O,,COCCO,,O=S(=O)(O)O,,val
US20140080822A1,C=Cc1c(-c2ccnn2C2CCCCO2)ccc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1C(=O)OC>>C=Cc1c(-c2ccn[nH]2)ccc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1C(=O)OC,Cl,CO,,O=C([O-])O.[Na+],,val
US06017919,CCCCCBr.CCCCCOC(=O)c1ccc(OC)c(N)c1CSC>>CCCCCNc1c(OC)ccc(C(=O)OCCCCC)c1CSC,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20090143367A1,COc1cc(F)c2nc(C)c3c(C)nc(Br)n3c2c1.Cc1ccccc1B(O)O>>COc1cc(F)c2nc(C)c3c(C)nc(-c4ccccc4C)n3c2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20150104384A1,C#CC(=O)OC.COc1cc[n+](N)cc1>>COC(=O)c1cnn2ccc(OC)cc12,,CN(C)C=O,,[I-].[K+],,val
US20020143034A1,COC(=O)[C@H](Cc1ccc(O)cc1)N(Cc1ccccc1)Cc1ccccc1.COCCl>>COCOc1ccc(C[C@@H](C(=O)OC)N(Cc2ccccc2)Cc2ccccc2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050148627A1,CCOC(=O)C1=Cc2cc(Cl)c(OC)c(C)c2OC1C(F)(F)F.O=C1CCC(=O)N1Br>>CCOC(=O)C1=Cc2cc(Cl)c(OC)c(CBr)c2OC1C(F)(F)F,,ClC(Cl)(Cl)Cl,,,,val
US04818766,COC(=O)C1=C(C)NC(C)=C(C(=O)OCCOc2ccc(CCN)cc2)C1c1cccc([N+](=O)[O-])c1.N#Cc1ccccc1OCC1CO1>>COC(=O)C1=C(C)NC(C)=C(C(=O)OCCOc2ccc(CCNCC(O)COc3ccccc3C#N)cc2)C1c1cccc([N+](=O)[O-])c1,,CC(C)O,,,,val
US20060122184A1,C[C@@H](C[C@H](NC(=O)c1ccc(-c2ccccc2Cl)cc1)C(=O)NC1(C#N)CCSCC1)c1ccccc1.O=S([O-])OO>>C[C@@H](C[C@H](NC(=O)c1ccc(-c2ccccc2Cl)cc1)C(=O)NC1(C#N)CCS(=O)(=O)CC1)c1ccccc1,,CO,,O,,val
US05834471,CCOC(=O)c1ccc(F)cc1.c1nc[nH]n1>>CCOC(=O)c1ccc(-n2cncn2)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150329538A1,CC(C)(C)OC(=O)N1CCC[C@H](Oc2ccc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)C1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C1NCCc2[nH]c(-c3cccc4ccc(O[C@H]5CCCNC5)nc34)cc21,,ClCCl,,,,val
US05166152,C1CCOC1.CCN(CC)CC.N#CC(C(=O)Nc1ccccc1)C(=O)c1nn(-c2ccccc2)c2c1CSc1ccc(N)cc1-2>>N#CC(C(=O)Nc1ccccc1)C(=O)c1nn(-c2ccccc2)c2c1CSc1ccc(N=CN3CCOCC3)cc1-2,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US20150175594A1,O=C(O)[C@H]1CCCN1.O=C=Nc1sc2c(c1-c1nc(C3CC3)no1)CCC2>>O=C(O)[C@H]1CCCN1C(=O)Nc1sc2c(c1-c1nc(C3CC3)no1)CCC2,,CO,ClCCl,,,val
US20070123563A1,C[C@](O)(CBr)C(=O)O.N#Cc1ccc(N)cc1C(F)(F)F>>C[C@](O)(CBr)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1,,C1CCOC1,O,CCN(CC)CC,O=S(Cl)Cl,val
US20160096827A1,CC(C)(C)OC(=O)N1CCCC[C@H]1C(=O)O.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@H]1CCNC[C@H]1F>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@H]1CCN(C(=O)[C@@H]2CCCCN2)C[C@H]1F,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20100130489A1,O=[N+]([O-])c1cc(Br)ccc1F.c1c[nH]cn1>>O=[N+]([O-])c1cc(Br)ccc1-n1ccnc1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20160237090A1,CS(=O)(=O)OS(C)(=O)=O.C[C@H]1Cn2ncc(N3CNCC3=O)c2CN1C(=O)OC(C)(C)C>>C[C@H]1Cn2ncc(N3CN(S(C)(=O)=O)CC3=O)c2CN1C(=O)OC(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05006534,CCCCCCC(OC(C)=O)c1ccccc1CBr.Oc1ccc2cccc(O)c2n1>>CCCCCCC(OC(C)=O)c1ccccc1COc1cccc2ccc(=O)[nH]c12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140094474A1,C[C@@H](CO)NC(=O)OC(C)(C)C.N#Cc1c(F)cc(-c2ccn[nH]2)c(F)c1Cl>>C[C@H](N)Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2F)n1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130079335A1,CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OS(=O)(=O)C(F)(F)F)ccc2-n2c(C)nnc21.COc1ccc(B(O)O)cc1>>CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(-c3ccc(OC)cc3)ccc2-n2c(C)nnc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US03947434,Cc1cc(Nc2ccccc2)c2c(ccc3nc[nH]c32)n1.Cl.Nc1ccc(F)c(Cl)c1>>Cc1cc(Nc2ccc(F)c(Cl)c2)c2c(ccc3nc[nH]c32)n1.Cl,,CCO,,,,val
US20030087952A1,CCOC(=O)CNC.O=C(O)C#Cc1ccccc1F>>CCOC(=O)CN(C)C(=O)C#Cc1ccccc1F,CN(C)c1ccncc1,ClCCl,,CN1CCOCC1,Cl,val
US20110190489A1,COc1ccc2c(c1)c(B1OC(C)(C)C(C)(C)O1)cn2C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)n2c(I)cc3c4c(cnc32)cnn4C)cc1>>COc1ccc2c(c1)c(-c1cc3c4c(cnc3n1S(=O)(=O)c1ccc(C)cc1)cnn4C)cn2C(=O)OC(C)(C)C,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,ClCCl,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20130289033A1,Cc1cccc(B(O)O)c1.O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(I)cc1>>Cc1cccc(-c2ccc(C(=O)NCCc3c[nH]c4ccc(Cl)cc34)cc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20040186102A1,O=[N+]([O-])c1ccc2c(c1)C(=NCCN1CCc3ccccc3C1)CCC2>>O=[N+]([O-])c1ccc2c(c1)C(NCCN1CCc3ccccc3C1)CCC2,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150197512A1,CC(C)(C)[Si](C)(C)OCCCc1ccc(C=O)s1>>O=Cc1ccc(CCCO)s1,,CO,O,,,val
US20110105761A1,Brc1ccc(-n2ccnc2)cc1.CCCCCCBr>>CCCCCCn1cc[n+](-c2ccc(Br)cc2)c1.[Br-],,C1CCOC1,,,,val
US20060199833A1,COC(=O)c1c2ccccc2nc2occc12>>O=C(O)c1c2ccccc2nc2occc12,,CO,,Cl,[Na+].[OH-],val
US20060241115A1,COc1cc2nccc(Cl)c2cc1OC.Oc1ccc2ccc(O)cc2c1>>COc1cc2nccc(Oc3ccc4ccc(O)cc4c3)c2cc1OC,[Cu],CN1CCCC1=O,O,[K+].[OH-],,val
US20070027185A1,CC(C)(C)OC(=O)N1CCCC(CO)C1.COC(=O)c1ccc(C(C)C)cc1O>>COC(=O)c1ccc(C(C)C)cc1OCC1CCCN(C(=O)OC(C)(C)C)C1,,C1CCOC1,ClCCl,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110053973A1,COC(=O)c1cc2nccc(Oc3ccc(N)c(F)c3)c2s1.Cc1ccc(F)c(N=C=O)c1>>COC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1,,CCOC(C)=O,,,,val
US20110294781A1,Nc1cc(-c2ccccc2)[nH]n1.O=C(Cl)CC(=O)Cl>>Clc1cc(Cl)n2nc(-c3ccccc3)cc2n1,,CC#N,O,,,val
US20120289551A1,COc1ccccc1CCc1ccnc(N)c1.O=C=NC(=O)c1ccccc1>>COc1ccccc1CCc1ccnc(NC(=O)NC(=O)c2ccccc2)c1,,ClCCl,,,,val
US20040248872A1,CC(CCOS(C)(=O)=O)=C(F)F.O=C(O)c1cc2ccccc2s1>>CC(CCOC(=O)c1cc2ccccc2s1)=C(F)F,,O,,CN(C)C=O,O=C([O-])O.[Na+],val
US20080280911A1,CCOC(=O)c1c[nH]c2c(F)cc(I)cc2c1=O>>O=C(O)c1c[nH]c2c(F)cc(I)cc2c1=O,,CO,,Cl,[Na+].[OH-],val
US06436966B1,CC(C)(C)c1ccc(CC#N)cc1.CCOC(=O)c1ccncc1>>CC(C)(C)c1ccc(C(C#N)C(=O)c2ccncc2)cc1,,CC(C)(C)O,O,CC(C)(C)[O-].[K+],,val
US20040138449A1,CNCC(O)c1cccc(N)c1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2sc(CCl)cc21>>CN(Cc1cc2c(s1)c(=O)c(C(=O)NCc1ccc(Cl)cc1)cn2C)CC(O)c1cccc(N)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20100286145A1,COC(=O)c1cc(CO)cc(C(=O)N(C)Cc2nc(C)co2)c1>>COC(=O)c1cc(C=O)cc(C(=O)N(C)Cc2nc(C)co2)c1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=S([O-])([O-])=S.[Na+].[Na+],val
US20070287725A1,CCOCc1nc2cnc3cccnc3c2n1Cc1cc(-c2ccc(F)cc2)no1.O=C(OO)c1cccc(Cl)c1>>CCOCc1nc2c[n+]([O-])c3cccnc3c2n1Cc1cc(-c2ccc(F)cc2)no1,,ClCCl,,,,val
US20040181067A1,Cc1ccc(S(=O)(=O)OC2COC2)cc1.O=C(Nc1nccs1)C(CC1CCOCC1)c1ccc(S)cc1>>O=C(Nc1nccs1)C(CC1CCOCC1)c1ccc(SC2COC2)cc1,,CC(=O)N(C)C,,[I-].[K+],O=C([O-])O.[Na+],val
US20120046269A1,NC(=O)c1cccc2c(NCc3ccc(N)cc3)ncnc12.O=S(=O)(Cl)c1ccccc1>>NC(=O)c1cccc2c(NCc3ccc(NS(=O)(=O)c4ccccc4)cc3)ncnc12,,ClCCl,,CCN(CC)CC,,val
US06537948B1,COC(=O)C(C)O.Cc1ncc(OCc2ccccc2)c(Cl)n1>>COC(=O)C(C)Oc1nc(C)ncc1OCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US05492895,CC(C)(C)OC(=O)N[C@@H](CC(N)=O)C(=O)O>>CC(C)(C)OC(=O)NC(CC#N)C(=O)O,,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20020198156A1,CCCCCC(CC(=O)ON1C(=O)CCC1=O)C(=O)NC(C(=O)N1CCCC1COCc1ccccc1)C(C)C.NOCc1ccccc1>>CCCCCC(CC(=O)NOCc1ccccc1)C(=O)NC(C(=O)N1CCCC1COCc1ccccc1)C(C)C,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20110046147A1,COc1ccc(-c2cnc(-c3cccc(OC)c3)s2)cc1>>Oc1ccc(-c2cnc(-c3cccc(O)c3)s2)cc1,,CCCCCC,CCOC(C)=O,,,val
US20080113966A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C=O)cnc21.C[Mg]Br>>CC(O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20110053933A1,COc1cc(F)ccc1OC1CCN(C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)CC1.Cl>>COc1cc(F)ccc1OC1CCN(C(=O)[C@@H](N)C(C)C)CC1.Cl,,CCO,,,,val
US20130210824A1,Fc1ccccc1CBr.Ic1n[nH]c2ncncc12>>Fc1ccccc1Cn1nc(I)c2cncnc21,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080015222A1,CC(=O)c1cccc2ncn(CC(=O)NCc3ccc(C(C)(C)C)cc3)c12>>CC(O)c1cccc2ncn(CC(=O)NCc3ccc(C(C)(C)C)cc3)c12,,CCO,,[BH4-].[Na+],,val
US20140249196A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCC[C@H]1CCO1>>Cc1ccc(S(=O)(=O)OCC[C@H]2CCO2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US20130079338A1,FC(F)(F)c1ccc(Nc2ncnc(/C=C/c3ccc4c(cnn4C4CCCCO4)c3)n2)cc1>>FC(F)(F)c1ccc(Nc2ncnc(CCc3ccc4c(cnn4C4CCCCO4)c3)n2)cc1,[Pd],CCOC(C)=O,,,,val
US20060276496A1,BrCCCBr.COC(=O)c1ccc2c(c1)c(CC#N)cn2C(=O)OC(C)(C)C>>COC(=O)c1ccc2c(c1)c(C1(C#N)CCC1)cn2C(=O)OC(C)(C)C,,CCOCC,CS(C)=O,[H-].[Na+],,val
US20010037023A1,O=C1CCC(CCCOC2CCOCC2)(c2ccc(Cl)c(Cl)c2)CN1>>Clc1ccc(C2(CCCOC3CCOCC3)CCCNC2)cc1Cl,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20010051623A1,COC(=O)C1CCc2c(cccc2OC)C1.O=[N+]([O-])O>>COC(=O)C1CCc2c(OC)ccc([N+](=O)[O-])c2C1,,CC(=O)OC(C)=O,,CCOCC,,val
US20130184238A1,CCCS(=O)(=O)Cl.CCCS(=O)(=O)N(CCO)C1CC1>>CCCS(=O)(=O)OCCN(C1CC1)S(=O)(=O)CCC,CN(C)c1ccncc1,ClCCl,,,,val
US20100105700A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.C[C@]12CCC(=O)N(C3CC3)C1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(OS(=O)(=O)C(F)(F)F)=CC[C@@H]12>>C[C@]12CCC(=O)N(C3CC3)C1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3ccccn3)=CC[C@@H]12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20020010206A1,C=CC1=C(C(=O)OCC)C(C(F)(F)F)Oc2ccc(Cl)cc21>>CCC1=C(C(=O)O)C(C(F)(F)F)Oc2ccc(Cl)cc21,[Pd],CO,,[H][H],,val
US20050245616A1,Br[Mg]c1ccccc1.CON(C)C(=O)[C@@H](CO[Si](C)(C)C(C)(C)C)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N[C@H](CO[Si](C)(C)C(C)(C)C)C(=O)c1ccccc1,,C1CCOC1,,,,val
US03978132,CC(C)(C)C(=O)c1ccc(CBr)cc1.Oc1ccccc1>>CC(C)(C)C(=O)c1ccc(COc2ccccc2)cc1,,CC(=O)N(C)C,,[H-].[Na+],,val
US20100256186A1,Cn1cnc(S(=O)(=O)Cl)c1.O=C(c1ccccc1)C1CCNCC1>>Cn1cnc(S(=O)(=O)N2CCC(C(=O)c3ccccc3)CC2)c1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US05159077,CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(CC4CCN(C=O)CC4)CC3)cc21.Cl>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(CC4CCNCC4)CC3)cc21.Cl,,C1COCCO1,,,,val
US20060172983A1,COC(=O)C(C)Cl.COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O>>COC(=O)C(C)Oc1ccc(CNC(=O)CCCCC=CC(C)C)cc1OC,,CC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20050256154A1,CCOC(=O)c1cnc(N)c2c(COc3ccc(Br)cc3)csc12.NC(CO)CO>>Nc1ncc(C(=O)NC(CO)CO)c2scc(COc3ccc(Br)cc3)c12,,CCOC(C)=O,CO,,,val
US20100130495A1,O=CCO.c1ncc(-c2ccc(Nc3nc4c(c(NCC5CCOCC5)n3)CNCC4)cc2)o1>>OCCN1CCc2nc(Nc3ccc(-c4cnco4)cc3)nc(NCC3CCOCC3)c2C1,,CO,,CC(=O)O,,val
US20110077252A1,NC(=NO)c1ccc(NC(=O)C(F)Cl)cn1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1ccc(-c2noc(C(F)(F)F)n2)nc1)C(F)Cl,,C1CCOC1,,,,val
US20160039801A1,COc1ncccc1C1CCCC1CO.O=Cc1c(O)cccc1O>>COc1ncccc1C1CCCC1COc1cccc(O)c1C=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04563446,Cc1ccc(S(=O)(=O)N=C=O)cc1.OCCCCC/C=C(\c1ccccc1)c1cccnc1>>Cc1ccc(S(=O)(=O)NC(=O)OCCCCC/C=C(\c2ccccc2)c2cccnc2)cc1,,ClCCl,,,,val
US05071999,C=CCN(C(=O)OCC)C(C)C=O.O=C(O)CNCc1ccccc1>>CCOC(=O)N1CC2CCN(Cc3ccccc3)C2C1C,,Cc1ccccc1,,O,,val
US04795748,CC(=O)Oc1ccc(C(=O)Oc2c(F)c(F)c(F)c(F)c2F)cc1>>O=C(Oc1c(F)c(F)c(F)c(F)c1F)c1ccc(O)cc1,,C1CCOC1,,Cl,,val
US20140155391A1,COC(=O)c1ccc(N)c(OCC2CC2)c1.O=S(=O)(Cl)CCCl>>C=CS(=O)(=O)Nc1ccc(C(=O)OC)cc1OCC1CC1,,ClCCl,,c1ccncc1,,val
US20090099231A1,C=O.O=C(NCCc1ccc(F)cc1)C(F)(F)F>>O=C(N1CCc2ccc(F)cc2C1)C(F)(F)F,,O,,CC(=O)O,O=S(=O)(O)O,val
US20120214803A1,Cc1cc(S(=O)(=O)Nc2cccc3cccnc23)c([N+](=O)[O-])cc1F>>Cc1cc(S(=O)(=O)Nc2cccc3cccnc23)c(N)cc1F,Cl,CCO,,Cl[Sn]Cl,,val
US03992189,C[Mg]Cl.O=C1C2=C(CCCC2)C(=O)N1c1ccc(Cl)cc1F>>CC1(O)C2=C(CCCC2)C(=O)N1c1ccc(Cl)cc1F,,C1CCOC1,,[Cl-].[NH4+],,val
US20110112065A1,CCN(Cc1ccccc1)CC1OCc2ccc(S(C)(=O)=O)cc2O1>>CCNCC1OCc2ccc(S(C)(=O)=O)cc2O1,[Pd],CCO,,,,val
US20090275624A1,COc1ccc2nc(-c3ccc4c(c3)OCO4)sc2c1[N+](=O)[O-]>>COc1ccc2nc(-c3ccc4c(c3)OCO4)sc2c1N,[Pd],CO,,[H][H],,val
US20040030178A1,COC(=O)CCCCC(=O)C1CO1>>COC(=O)CCCCC(=O)CCO,O=[Pt]=O,CCOC(C)=O,,,,val
US05552420,CCc1ncc(CCCO)n1C.Cn1nnc(-c2ccc(O)cc2)n1>>CCc1ncc(CCCOc2ccc(-c3nnn(C)n3)cc2)n1C,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150315160A1,CC(C)(C)O.COc1ccc(COc2ccc(-c3nocc3C(=O)O)cc2)cc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COc1ccc(COc2ccc(-c3nocc3NC(=O)OC(C)(C)C)cc2)cc1,,CN(C)C=O,,CCN(CC)CC,,val
US20140171405A1,CC(C)OB1OC(C)(C)C(C)(C)O1.COc1cc(OC)c(F)c(I)c1F>>COc1cc(OC)c(F)c(B2OC(C)(C)C(C)(C)O2)c1F,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20100009975A1,CCN(CCN1CCSc2ccc([N+](=O)[O-])cc21)C(=O)OC(C)(C)C>>CCN(CCN1CCSc2ccc(N)cc21)C(=O)OC(C)(C)C,[Ni],CCO,CCOC(C)=O,NN,O,val
US04367237,CC(=O)OC(C)=O.CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C/CCCC(=O)OC>>CCCCC[C@@H](/C=C/[C@H]1C=CC(=O)[C@@H]1C/C=C\CCCC(=O)OC)OC(C)=O,,c1ccncc1,,,,val
US04451463,FC(F)(F)CN=C=S.Nc1cnn(-c2cccc(CO)c2)n1>>OCc1cccc(-n2ncc(NC(=S)NCC(F)(F)F)n2)c1,,CC#N,,,,val
US20150065515A1,CC(=O)OCc1cc2nc3n(c2cc1S(C)(=O)=O)CCN[C@@H]3C(C)C.CCOC(=O)c1cnc(Cl)nc1C(F)(F)F>>CCOC(=O)c1cnc(N2CCn3c(nc4cc(COC(C)=O)c(S(C)(=O)=O)cc43)[C@H]2C(C)C)nc1C(F)(F)F,,CC(C)O,ClCCl,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US06319902B1,CC(C)(C)OC(=O)N[C@@H](Cc1cscn1)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.Cl>>Cl.N[C@@H](Cc1cscn1)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1,,CCOC(C)=O,,CCOCC,,val
US20130168659A1,CCCCCCC(CI)CCCC.c1ccsc1>>CCCCCCC(CCCC)Cc1cccs1,,C1CCOC1,,O,[Li]CCCC,val
US05254558,CC(C)C(NC(=O)Cn1c(-c2ccccc2)ncc(NC(=O)NCc2cccnc2)c1=O)C(O)C(F)(F)F>>CC(C)C(NC(=O)Cn1c(-c2ccccc2)ncc(NC(=O)NCc2cccnc2)c1=O)C(=O)C(F)(F)F,,ClCCl,,CO,,val
US20150329529A1,CC(C)C1CCC(=O)CC1.O=S(=O)(N(c1ccccn1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)C1CC=C(OS(=O)(=O)C(F)(F)F)CC1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20040122029A1,COC(=O)C(Cc1cnc(Nc2ccccc2)nc1Nc1ccccc1)c1ccccc1>>O=C1C(c2ccccc2)Cc2cnc(Nc3ccccc3)nc2N1c1ccccc1,,CC(=O)O,CCOC(C)=O,O=S(=O)(O)O,,val
US20050187272A1,O=[N+]([O-])c1ccc(CN2CCSC2)cc1>>Nc1ccc(CN2CCSC2)cc1,,Cl,,,,val
US20110230459A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.NC1CC1>>CC(C)(C)OC(=O)N1CCC(NC2CC2)CC1,CC(=O)O,CC(Cl)Cl,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100150866A1,C=CCCCCCBr.CC(C)(C)OC(=O)NS(=O)(=O)C1CC1>>C=CCCCCCC1(S(=O)(=O)NC(=O)OC(C)(C)C)CC1,,C1CCOC1,,[Li]CCCC,,val
US20120010247A1,BrCC1CC1.Oc1ccc(I)cn1>>Ic1ccc(OCC2CC2)nc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05658943,CCOC(=O)C(NC(=O)C(c1ccccc1)c1ccccc1)C(c1ccc2c(c1)OCO2)c1ccc2c(c1)OCO2>>O=C(NC(C(=O)O)C(c1ccc2c(c1)OCO2)c1ccc2c(c1)OCO2)C(c1ccccc1)c1ccccc1,,CO,,[Na+].[OH-],,val
US20090042929A1,CC(C(=O)O)(c1ccccc1)c1ccccc1.CNCc1cccs1>>CN(Cc1cccs1)C(=O)C(C)(c1ccccc1)c1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US04883815,CC(=O)OC(C)=O.COc1ccc2c(c1)CCC1=C2CCCN1>>COc1ccc2c(c1)CCC1=C2CCCN1C(C)=O,,c1ccncc1,,,,val
US05854234,C=CCC1CCCCN=C1OC.[Cl-].[NH4+]>>C=CCC1CCCCNC1=N.Cl,,CO,,,,val
US20130211075A1,N#CC1(c2ccc(Br)cn2)CCOCC1>>Brc1ccc(C2CCOCC2)nc1,,Cl,,O=C([O-])[O-].[K+].[K+],,val
US20140031360A1,CC(C)(C)OC(=O)NC1CCNCC1.Cc1ccc(S(=O)(=O)n2cc(-c3cncc(Cl)n3)c3cc(-c4c(F)cccc4Cl)ccc32)cc1>>Cc1ccc(S(=O)(=O)n2cc(-c3cncc(N4CCC(NC(=O)OC(C)(C)C)CC4)n3)c3cc(-c4c(F)cccc4Cl)ccc32)cc1,,CS(C)=O,,,,val
US20040106620A1,CCC(C)S.CCc1nc(-c2ccc(OC)cc2OC)c(CC)nc1Cl>>CCc1nc(-c2ccc(OC)cc2OC)c(CC)nc1SC(C)CC,,C1CCOC1,,[H-].[Na+],,val
US20090029965A1,CC(C)(C)OC(=O)N1CCN(C(=O)CBr)CC1.COC(=O)c1ccc(O)cc1Cl>>COC(=O)c1ccc(OCC(=O)N2CCN(C(=O)OC(C)(C)C)CC2)cc1Cl,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04386085,BrBr.CCN(CC)c1ccccc1>>CCN(CC)c1ccc(Br)cc1,,CC(=O)O,,,,val
US04697018,Cc1ccc(S(C)(=O)=O)c(-c2ccc(N(C)C)cc2)c1-c1ccccc1.O=C(O)c1cc2ccccc2[nH]1>>CN(C)c1ccc(C(c2ccccc2)c2c(C(=O)O)[nH]c3ccccc23)cc1,,CCO,,Cl,,val
US20070117824A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCCC2(CCNC2)C1.CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(Cl)nc1>>CC(=O)N1CCC2(CCCN(c3ccc(C(=O)Nc4cc(-c5cccs5)ccc4N)cn3)C2)C1,,CN(C)C=O,,CCN(CC)CC,,val
US20110021434A1,C=CCOc1ccc(C[C@H](NS(=O)(=O)c2ccc(F)cc2)C(=O)N[C@@H](CC(C)C)C(=O)O)cc1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O>>C=CCOc1ccc(C[C@H](NS(=O)(=O)c2ccc(F)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=C)C(=O)OC)cc1,,CN(C)C=O,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20090143444A1,O=Cc1c[nH]c(-c2ccc(C3CCCCC3)cc2)c1.O=S(=O)(Cl)c1cccnc1>>O=Cc1cc(-c2ccc(C3CCCCC3)cc2)n(S(=O)(=O)c2cccnc2)c1,,C1CCOC1,,[H-].[Na+],,val
US06080754,CC(=O)O.CCCc1ccc(N)cn1>>CCCc1ccc(NC(C)=O)cn1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US05656662,BrBr.CCCCCC=CCC=CCC=CCCO>>CCCCC/C=C\C/C=C\C/C=C\CCBr,,CC#N,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20140045872A1,Cc1ccncc1I.O=C1NCCc2cnccc21>>Cc1ccncc1N1CCc2cnccc2C1=O,I[Cu]I,C1COCCO1,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US06706732B1,Cc1cc(C)c2c(n1)CC(c1cc(F)ccc1C)CC2=O.Cl.N=C(N)NN>>Cc1cc(C)c2c(n1)CC(c1cc(F)ccc1C)CC2=NNC(=N)N.Cl,,CCO,,Cl,O,val
US20060009451A1,c1ccc(COc2ccc(-c3c4c(nc5ccnn35)CCCCC4)cc2)cc1>>Oc1ccc(-c2c3c(nc4ccnn24)CCCCC3)cc1,[Pd],CO,,CCOC(C)=O,,val
US20160159809A1,CC(C)(C)OC(=O)N1CCCc2ccc(-c3nc(NCC(c4ccccc4)c4ccccc4)c4ccccc4n3)cc21>>c1ccc(C(CNc2nc(-c3ccc4c(c3)NCCC4)nc3ccccc23)c2ccccc2)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20130217702A1,COC(C)(OC)N(C)C.COc1ccc2[nH]c(C(=N)NO)c(Cl)c2c1>>COc1ccc2[nH]c(-c3noc(C)n3)c(Cl)c2c1,,ClCCl,,,,val
US20100068301A1,CC(C)(C)OC(=O)N1c2ccccc2C[C@H]1CO.Cc1ccccc1S(=O)(=O)Cl>>Cc1ccc(S(=O)(=O)OC[C@@H]2Cc3ccccc3N2C(=O)OC(C)(C)C)cc1,,ClCCl,,O,c1ccncc1,val
US20140275071A1,Cn1c(=O)n(CCCO)c(=O)c2c1nc(Br)n2Cc1ccc(F)cc1.Oc1ccccc1F>>Cn1c(=O)n(CCCO)c(=O)c2c1nc(Oc1ccccc1F)n2Cc1ccc(F)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110257137A1,C[Si](C)(C)C#Cc1cc(C(F)(F)F)ccc1N>>C#Cc1cc(C(F)(F)F)ccc1N,,O=C([O-])O,[Na+],CO,O=C([O-])[O-].[K+].[K+],val
US20040138223A1,CCOC(OCC)c1ccc(CNc2ccc(C(C)C)cc2)cc1.COc1ccc2c(c1)C(C(=O)O)CCC2>>COc1ccc2c(c1)C(C(=O)N(Cc1ccc(C=O)cc1)c1ccc(C(C)C)cc1)CCC2,,CO,,Cl,,val
US04088474,CCOC(=O)C(C)Br.Oc1ccc(Cc2ccc(Cl)cc2)cc1>>CCOC(=O)C(C)Oc1ccc(Cc2ccc(Cl)cc2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160024096A1,CC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O.O=Cc1cccs1>>O=C(C=Cc1cccs1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O,,CCO,O,[Na+].[OH-],,val
US05714489,COC(=O)Cn1c(=O)c(=O)[nH]c2cc(C(F)(F)F)c(-n3cccc3)cc21>>O=C(O)Cn1c(=O)c(=O)[nH]c2cc(C(F)(F)F)c(-n3cccc3)cc21,,C1CCOC1,O,[Li+].[OH-],,val
US20140148433A1,BrCC1CC1.COc1ccc(Cn2c(=O)[nH]c3cnc(-c4nn(Cc5ccccc5F)c5ncccc45)nc32)c(OC)c1>>COc1ccc(Cn2c(=O)n(CC3CC3)c3cnc(-c4nn(Cc5ccccc5F)c5ncccc45)nc32)c(OC)c1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04634704,Brc1nccs1.OCCN1CCC(Nc2nc3ccccc3n2Cc2ccc(F)cc2)CC1>>Fc1ccc(Cn2c(NC3CCN(CCOc4nccs4)CC3)nc3ccccc32)cc1,,Cc1ccccc1,,CS(C)=O,[H-].[Na+],val
US20140179666A1,C=C(C)CNc1cc(Cl)nnc1Cl.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=C(C)CN(C(=O)OC(C)(C)C)c1cc(Cl)nnc1Cl,CN(C)c1ccncc1,C1CCOC1,,,,val
US20160176811A1,C#CCOC(=O)NCC(=O)NC[C@H](NC(=O)OC(C)(C)C)C(=O)O>>C#CCOC(=O)NCC(=O)NC[C@H](N)C(=O)O,,C1COCCO1,CC#N,Cl,,val
US20160031829A1,CI.N#Cc1ccc(C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)CC3)c(Br)c1>>CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1Br,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],val
US06069176,CCOC(=O)CC(C)=O.COc1ccc(C(=O)CBr)cc1.c1ccccc1>>CCOC(=O)C(CC(C)=O)CC(=O)c1ccc(OC)cc1,,c1ccccc1,,CC(C)(C)[O-].[K+],,val
US20110207777A1,CO[C@@H]1CC[C@H](N2CCC(Nc3cc(C)cc(F)c3N)CC2)CC1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CO[C@@H]1CC[C@H](N2CCC(n3c(=O)[nH]c4c(F)cc(C)cc43)CC2)CC1.Cl,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120264749A1,Cc1cc(C(=O)N2CCC3(CC2)CNC(C)(C)CO3)ccc1OC(C)C.Clc1ncccn1>>Cc1cc(C(=O)N2CCC3(CC2)CN(c2ncccn2)C(C)(C)CO3)ccc1OC(C)C.Cl,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05294734,C=C(CCCCCCNC(=O)OCc1ccccc1)C1OC=NC1C(=O)OCC.O>>C=C(CCCCCCNC(=O)OCc1ccccc1)C(O)C(NC=O)C(=O)OCC,,C1CCOC1,,,,val
US20150087663A1,C[C@H](N)c1nc2cccc(-c3cnn(C)c3)c2c(=O)n1-c1ccccc1.Cc1noc(-c2c(N)ncnc2Cl)n1>>Cc1noc(-c2c(N)ncnc2N[C@@H](C)c2nc3cccc(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)n1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US05952386,NCCOc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl.O=C=Nc1ccc(OC(F)(F)F)cc1>>O=C(NCCOc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl)Nc1ccc(OC(F)(F)F)cc1,,Cc1ccccc1,,,,val
US20100298339A1,BrCC1CCCO1.Oc1cccc(-c2cccc3nc(Nc4ccc(OCCN5CCCC5)cc4)nn23)c1>>c1cc(OCC2CCCO2)cc(-c2cccc3nc(Nc4ccc(OCCN5CCCC5)cc4)nn23)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100160362A1,CC(C)c1nc(CCl)cs1.COc1ccc2c(n1)C1(CO2)C(=O)Nc2cccc(Br)c21>>COc1ccc2c(n1)C1(CO2)C(=O)N(Cc2cnc(C(C)C)s2)c2cccc(Br)c21,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100190775A1,CSc1ncc2c(n1)N1CCC[C@H]1CN(c1cccc(C(N)=NO)c1)C2=O.O=C(O)C(F)(F)F>>CSc1ncc2c(n1)N1CCC[C@H]1CN(c1cccc(-c3noc(C(F)(F)F)n3)c1)C2=O,,ClCCl,,CCN(CC)CC,,val
US04816452,CCOC(=O)/C(=N\OC1CCCCC1)c1csc(N)n1>>Nc1nc(/C(=N/OC2CCCCC2)C(=O)O)cs1,,CCO,,O,[Na+].[OH-],val
US20050154023A1,CCOC(=O)CC1CNc2ccccc21.COc1ccc(S(=O)(=O)Cl)c2ccccc12>>CCOC(=O)CC1CN(S(=O)(=O)c2ccc(OC)c3ccccc23)c2ccccc21,,ClCCl,O,CCN(CC)CC,,val
US07994202B2,BrC1CCCC1.CCOC(=O)c1csc(-n2nc(-c3ccccc3)c3ccc(O)cc32)n1>>CCOC(=O)c1csc(-n2nc(-c3ccccc3)c3ccc(OC4CCCC4)cc32)n1,,CN(C)C=O,,O,[H-].[Na+],val
US20070197512A1,C=CC(=O)OC.Cc1cc(Cl)c2c(c1)NC(=O)[C@@H](C(C)C)O2>>COC(=O)CCN1C(=O)[C@@H](C(C)C)Oc2c(Cl)cc(C)cc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20090197834A1,CCOC(=O)CNCc1cn(C2CCOC2)c2cc(NC3CCCCC3)c(F)cc2c1=O.O=C(O)C(=O)O>>CCOC(=O)CNCc1cn(C2CCOC2)c2cc(NC3CCCCC3)c(F)cc2c1=O.O=C(O)C(=O)O,,CCO,,CCOC(C)=O,,val
US20160046648A1,CI.O=C(c1cc2ncccc2[nH]1)N1CCC(c2ccccc2C(F)(F)F)CC1>>Cn1c(C(=O)N2CCC(c3ccccc3C(F)(F)F)CC2)cc2ncccc21,,CN(C)C=O,,[H-].[Na+],,val
US04621081,CC(=O)OCC1=C(C(=O)OC(C)(C)C)N2C(=O)[C@@H](NC(=O)/C(=N\OC3(C(=O)OC(C)(C)C)CCC3)c3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)[C@H]2SC1>>CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)/C(=N\OC3(C(=O)O)CCC3)c3csc(N)n3)[C@H]2SC1,,CS(C)=O,,COc1ccccc1,O=C(O)C(F)(F)F,val
US20090131402A1,CC(C)(C)N=C=O.CC(C)(C)OC(=O)N1CCOc2nc(N3CCNCC3)ccc2C1>>CC(C)(C)NC(=O)N1CCN(c2ccc3c(n2)OCCN(C(=O)OC(C)(C)C)C3)CC1,,C1CCOC1,,CCOCC,,val
US20080194535A1,C=CCBr.CC(C)C[C@H](CO)NC(=O)C(F)(F)F>>C=CCOC[C@@H](CC(C)C)NC(=O)C(F)(F)F,,C1CCOC1,,[H-].[Na+],,val
US20130210768A1,CC1(CO)CC1.Cn1c(=O)[nH]c2ccc(-c3ccccc3C#N)nc21>>Cn1c(=O)n(CC2(C)CC2)c2ccc(-c3ccccc3C#N)nc21,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04269773,CC(C)=CC(=O)[O-].COC(=O)C(=C(C)C)N1C(=O)C2(C(=O)Cc3ccccc3)NC(C(=O)O)OC12.Cl>>COC(=O)C(=C(C)C)N1C(=O)C2(C(=O)Cc3ccccc3)NC(C(=O)CCl)OC12,,ClCCl,,O=S(Cl)Cl,,val
US20150266824A1,O=C1CCC(=O)N1Cl.Oc1ccnc2ccccc12>>O=c1c(Cl)c[nH]c2ccccc12,,CC(=O)O,,,,val
US20080051395A1,CC(C)(C)[Si](C)(C)OCc1ccn2nc(-c3cccc([N+](=O)[O-])c3)c(-c3ccnc(S(C)(=O)=O)n3)c2c1>>CC(C)(C)[Si](C)(C)OCc1ccn2nc(-c3cccc([N+](=O)[O-])c3)c(-c3ccncn3)c2c1,,CCO,ClCCl,[Na+].[OH-],,val
US20050148623A1,CC(C)(C)OC(=O)[C@@H](N1CCN(Cc2ccccc2C(F)(F)F)C1=O)C(C)(C)C>>CC(C)(C)[C@@H](C(=O)O)N1CCN(Cc2ccccc2C(F)(F)F)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100160280A1,COc1nc(=O)c(I)c[nH]1.Cc1ccc(Nc2ccc(O)cc2)nc1>>COc1ncc(I)c(Oc2ccc(Nc3ccc(C)cn3)cc2)n1,,CC#N,CCOC(C)=O,C1CCC2=NCCCN2CC1,,val
US04249931,COCC1CNC(c2ccc(Cl)cc2)O1.O=C(Cl)C(Br)CBr>>COCC1CNC(C(=O)C(Br)CBr)(c2ccc(Cl)cc2)O1,,c1ccccc1,,[Na+].[OH-],,val
US20140228579A1,NCc1ccccc1.O=C(Cl)c1ccco1>>O=C(NCc1ccccc1)c1ccco1,,ClCCl,,,,val
US20130245042A1,C[C@H](N)CCc1ccccc1.N#Cc1c(Br)ccnc1Br>>C[C@@H](CCc1ccccc1)Nc1ccnc(Br)c1C#N,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US03993679,COc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1>>COc1cc(N)cc(N)c1,[Pd],CO,,,,val
US20120270819A1,COC1O[C@H](COC(=O)c2ccccc2)[C@H](O)[C@H](OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1.COCCN(CCOC)S(F)(F)F>>COC1O[C@H](COC(=O)c2ccccc2)[C@@H](F)[C@H](OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1,,ClCCl,,,,val
US20160194316A1,CCOC(=O)C(C#N)=C(SC)SC.CNN>>CSc1c(C#N)c(=O)[nH]n1C,,CC#N,,,,val
US05008454,CCCCCCCCCCCCCCCCCCOCCCOS(C)(=O)=O.OCCCCO>>CCCCCCCCCCCCCCCCCCOCCCOCCCCO,,CS(C)=O,,O,[H-].[Na+],val
US20150175540A1,CC(=O)[C@@H]1CC[C@@H](CN2Cc3ccc(O)c(F)c3C2=O)CC1.N>>CC(N)[C@@H]1CC[C@@H](CN2Cc3ccc(O)c(F)c3C2=O)CC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20120165318A1,COC(=O)c1ccc2nc(-c3cc4ccccc4o3)c(N(C)C(C)C)nc2c1>>CC(C)N(C)c1nc2cc(C(=O)O)ccc2nc1-c1cc2ccccc2o1,,CO,,O,[Na+].[OH-],val
US04588738,O=C1c2cc(Br)cc(Br)c2CCC1Br.c1c[nH]cn1>>O=C1c2cc(Br)cc(Br)c2CCC1n1ccnc1,,CN(C)C=O,,,,val
US20080064720A1,COC(=O)C(O)Cc1ccc2nc(-c3c(Cl)cccc3Cl)ccc2c1.O=C(Cl)c1c(Cl)cccc1Cl>>COC(=O)C(Cc1ccc2nc(-c3c(Cl)cccc3Cl)ccc2c1)OC(=O)c1c(Cl)cccc1Cl,,c1ccncc1,,O=C([O-])O.[Na+],,val
US20150322048A1,CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1nc2ccc(B3OC(C)(C)C(C)(C)O3)cc2[nH]1.CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1ncc(-c2ccc3cc(Br)ccc3c2)[nH]1.Cc1ccccc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1ncc(-c2ccc3cc(-c4ccc(-c5cnc([C@@H]6C[C@H]7C[C@H]7N6C(=O)OCc6ccccc6)[nH]5)cc4)ccc3c2)[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20090286811A1,COc1cc(C=O)ccc1OCC1CC1.Cc1nc2sccn2c(=O)c1-c1ccc(C(F)(F)F)cc1>>COc1cc(/C=C/c2nc3sccn3c(=O)c2-c2ccc(C(F)(F)F)cc2)ccc1OCC1CC1,,CCO,,C,C[O-].[Na+],val
US20150210720A1,CCOC(=O)C(=O)CBr.O=C1CC(=O)CC2(CCOCC2)C1>>CCOC(=O)c1coc2c1C(=O)CC1(CCOCC1)C2,,CCO,,O=C([O-])O.[Na+],,val
US20120010208A1,CC(C)(C)OC(=O)N1CCCC2(CCNCC2)C1.Cc1ccc(S(=O)(=O)n2ccc3c(-c4c(-c5ccc(F)cc5)nc5ccc(Cl)nn45)ccnc32)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c(-c4c(-c5ccc(F)cc5)nc5ccc(N6CCC7(CCCN(C(=O)OC(C)(C)C)C7)CC6)nn45)ccnc32)cc1,,CCCCCO,,CCN(C(C)C)C(C)C,Cl,val
US20110015175A1,Cc1ncnn1-c1ccc(Nc2n[nH]c(C(CCCCCl)c3ccc(OC(F)(F)F)cc3)n2)cc1F>>Cc1ncnn1-c1ccc(Nc2nc3n(n2)CCCCC3c2ccc(OC(F)(F)F)cc2)cc1F,,CC(C)=O,,[I-].[Na+],,val
US05635395,CC(=O)NCCO.COC(=O)C1=C(C)NC(C)=C(C(=O)O)[C@@H]1c1cccc([N+](=O)[O-])c1>>CC(=O)NCCOC(=O)C1=C(C)NC(C)=C(C(=O)O)[C@H]1c1cccc([N+](=O)[O-])c1,,C1CCOC1,CCOC(C)=O,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20110053940A1,CC(C)(C)[Si](C)(C)OCc1cc(CCOS(C)(=O)=O)cc(Cl)c1Cl.[N-]=[N+]=[N-]>>CC(C)(C)[Si](C)(C)OCc1cc(CCN=[N+]=[N-])cc(Cl)c1Cl,,CCOCC,,CN(C)C=O,,val
US20130243677A1,CC1=NC(C)(C)CO1.CI>>CC1=[N+](C)C(C)(C)CO1.[I-],,C1CCOC1,,O,,val
US20100222319A1,CCNc1nc(Cl)ccc1C(=O)O.CN>>NC(=O)c1cccnc1,,C1CCOC1,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20030225283A1,CS(=O)(=O)c1ccc(C(CC2CCC(=O)CC2)C(=O)Nc2cnccn2)cc1Cl.NO>>CS(=O)(=O)c1ccc(C(CC2CCC(=NO)CC2)C(=O)Nc2cnccn2)cc1Cl,,CO,c1ccncc1,Cl,,val
US20030199520A1,CO.COc1cc(C)c(S(=O)(=O)N[C@H](COC(C)(C)C)C(=O)O)c(C)c1C>>COC(=O)[C@@H](COC(C)(C)C)NS(=O)(=O)c1c(C)cc(OC)c(C)c1C,,CO,ClCCl,C[Si](C)(C)C=[N+]=[N-],,val
US20030096788A1,CCC(=O)CC(=NO)[C@H]1O[C@@H](OC)[C@@H]2OC(C)(C)O[C@@H]21>>CCc1cc([C@H]2OC(O)[C@H](O)[C@@H]2O)no1,,CC(=O)O,,,,val
US05077297,O=C([O-])[O-].O=[N+]([O-])C1=CC(F)(F)C(F)(Cl)C([N+](=O)[O-])=C1Cl.O=c1cc(C(F)(F)F)nc[nH]1>>O=c1cc(C(F)(F)F)ncn1-c1c([N+](=O)[O-])cc(C(F)(F)F)c(Cl)c1[N+](=O)[O-],,CN(C)C=O,,O,,val
US20140038999A1,CC(C)(C)OC(=O)CN=C(c1ccccc1)c1ccccc1.O=S(=O)(OCCC(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)C(CCC(F)(F)F)N=C(c1ccccc1)c1ccccc1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20050043535A1,Cc1cc(NC(=O)NCCCl)c2ccccc2n1.OC1(Cc2ccccc2)CCNCC1>>Cc1cc(NC(=O)NCCN2CCC(O)(Cc3ccccc3)CC2)c2ccccc2n1,,C1CCOC1,ClCCl,O=C([O-])O.[Na+],,val
US20100273786A1,CC(C)(C)OC(=O)N[C@@H](CC(=O)N1CCn2c(C(F)(F)F)nc(C(=O)O)c2C1)Cc1cc(F)c(F)cc1F.CC(Cl)OC(=O)OC1CCCCC1>>CC(C)(C)OC(=O)N[C@@H](CC(=O)N1CCn2c(C(F)(F)F)nc(C(=O)OCCOC(=O)OC3CCCCC3)c2C1)Cc1cc(F)c(F)cc1F,,CN(C)C=O,,[I-].[K+],,val
US04719200,C[C@H](NC(=O)Nc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O>>C[C@H](NC(=O)Nc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O,,O,,,,val
US05658940,COC(=O)CC(N)c1ccc(OC)c(OC)c1.O=C1OC(=O)[C@@H]2CCC=C[C@H]12>>COC(=O)CC(c1ccc(OC)c(OC)c1)N1C(=O)[C@H]2C=CCC[C@H]2C1=O,,CC(=O)O,,Cl,CC(=O)[O-].[Na+],val
US05725798,CCCCCC[C@@H](C)OC(=O)c1ccc(C(=O)OCc2ccccc2)cc1>>CCCCCC[C@@H](C)OC(=O)c1ccc(C(=O)O)cc1,[Pd],C1CCOC1,,[H][H],,val
US06465478B1,CC(C)(C)OC(=O)CN1CN(c2ccccc2)C2(CCN(C3(c4ccccc4)CCCCCC3)CC2)C1=O.CO>>COC(=O)CN1CN(c2ccccc2)C2(CCN(C3(c4ccccc4)CCCCCC3)CC2)C1=O,,CO,,Cl,,val
US04954512,C1CCOC1.CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](C(=O)O)CC1.CCN(CC)CC.CCOC(=O)Cl.CN(C)C=O>>CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CC[C@@H](CNC(=O)OC(C)(C)C)CC1,,C1CCOC1,,Cl,,val
US04971982,COC(=O)c1ccc(C2CC(C)(C)Oc3ccc(C#N)cc32)nc1.O=C(OO)c1cccc(Cl)c1>>COC(=O)c1ccc(C2CC(C)(C)Oc3ccc(C#N)cc32)[n+]([O-])c1,,ClCCl,,,,val
US20130079302A1,CC(C)(C)CCBr.COC(=O)C1CCCC1=O>>COC(=O)C1(CCC(C)(C)C)CCCC1=O,,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US05686445,C1=CC2=C(CC1)c1ccsc1CC=N2.Cc1ccccc1C(=O)Nc1ccc(C(=O)Cl)cc1>>Cc1ccccc1C(=O)Nc1ccc(C(=O)C2C=CC3=C(C2)c2ccsc2CC=N3)cc1,,ClCCl,,CCN(CC)CC,,val
US04703072,CC1(C)CC(OC(=O)c2ccco2)CC(C)(C)N1>>CC1(C)CC(OC(=O)C2CCCO2)CC(C)(C)N1,[Ni],CO,,,,val
US20150087663A1,CC[C@H](NC(=O)OC(C)(C)C)C(=O)N(C(=O)c1c(Cl)cccc1[N+](=O)[O-])[C@@H]1C[C@@H]1F>>CC[C@H](NC(=O)OC(C)(C)C)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1C[C@@H]1F,[Zn],CC(=O)O,,,,val
US05919777,CS(=O)(=O)Cl.c1ccc(C[C@@H]2CNCCN2Cc2ccccc2)cc1>>CS(=O)(=O)N1CCN(Cc2ccccc2)[C@H](Cc2ccccc2)C1,,ClCCl,,O,O=C([O-])[O-].[K+].[K+],val
US20060074084A1,CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.CN(C)CCNC(=O)c1[nH]c2ccc(N)cc2c1-c1ccccc1>>CN(C)CCNC(=O)c1[nH]c2ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc2c1-c1ccccc1,,ClCCl,,CO,,val
US20160039811A1,CCOC(=O)C(C(C)C)n1ccc(OC)c(C#N)c1=O.O=C1CCC(=O)N1Br>>CCOC(=O)C(C(C)C)n1cc(Br)c(OC)c(C#N)c1=O,,CN(C)C=O,,,,val
US20090029975A1,CO.CS(=O)(=O)c1cc(CCC(=O)O)nc(-c2nc(=O)c3ccc(Cl)cc3s2)c1>>COC(=O)CCc1cc(S(C)(=O)=O)cc(-c2nc(=O)c3ccc(Cl)cc3s2)n1,CN(C)c1ccncc1,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20060074119A1,COC(=O)c1sc(-n2cnc3ccccc32)cc1C#Cc1ccccc1.N>>NC(=O)c1sc(-n2cnc3ccccc32)cc1C#Cc1ccccc1,,CO,,,,val
US20090012320A1,CC(C)C=O.CCOC(=O)CC(=O)[O-]>>CCOC(=O)C=CC(C)C,CN(C)c1ccncc1,CN(C)C=O,,,,val
US20100119424A1,Brc1ccc(Br)nc1.c1ccc(CC2CCNCC2)cc1>>Brc1ccc(N2CCC(Cc3ccccc3)CC2)nc1,[Pd],,,,,val
US20070004776A1,CNC.COC(=O)c1ccc(Oc2ccc(CC(NC(=O)OC(C)(C)C)C(=O)O)cc2)nc1>>COC(=O)c1ccc(Oc2ccc(CC(NC(=O)OC(C)(C)C)C(=O)N(C)C)cc2)nc1,,ClCCl,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20110070317A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(F)c(Cl)cnc21>>Fc1c(Cl)cnc2[nH]ccc12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140221393A1,COCCl.O=[N+]([O-])c1ccc(N2CCN(c3ccc(O)cc3)CC2)cc1>>COCOc1ccc(N2CCN(c3ccc([N+](=O)[O-])cc3)CC2)cc1,,ClCCl,,CC(C)NC(C)C,,val
US20080306060A1,BrBr.CCCC1CC(=O)CC(=O)C1>>CCCC1CC(=O)C(Br)C(=O)C1,,CC(=O)O,,,,val
US20130331378A1,COC(=O)c1cccc(Cc2c(-c3ccccc3)nn3cc(C#N)ccc23)n1>>N#Cc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1,,CO,,Cl,[K+].[OH-],val
US20060263411A1,Cc1ccc(C(=O)Cl)c(C)c1.NNC(N)=S>>Cc1ccc(-c2n[nH]c(=S)[nH]2)c(C)c1,,c1ccncc1,,,,val
US20110028442A1,CC(C)(C)OC(=O)N(CCc1cccc([N+](=O)[O-])c1)C[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12>>CC(C)(C)OC(=O)N(CCc1cccc(N)c1)C[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12,[Ni],CO,,,,val
US20020035110A1,C[C@H]1CN(C(=O)OC(C)(C)C)S(=O)(=O)O1.Cc1cc2[nH]c(C(O[SiH](C)C)C(C)(C)C(C)C)cc2cc1Br>>Cc1cc2c(cc1Br)cc(C(O[SiH](C)C)C(C)(C)C(C)C)n2[C@H](C)CNC(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20160141515A1,COc1nc2ccccc2cc1B(O)O.Fc1ccc(Br)cc1I>>COc1nc2ccccc2cc1-c1cc(Br)ccc1F,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US06001997,COc1ccc(COC(=O)C(O)N2C(=O)[C@@H](NC(=O)Cc3ccccc3)[C@H]2S)cc1.O=C(CBr)C1CCCO1>>COc1ccc(COC(=O)C(O)N2C(=O)[C@](NC(C)=O)(c3ccccc3)[C@H]2SCC(=O)C2CCCO2)cc1,,CC(C)=O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20060178359A1,CCOC(=O)/C=C/C1CCCCN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCCCC1/C=C/C(=O)O,,CCO,,[Na+].[OH-],,val
US20060194782A1,CCc1cccc(C)c1CNc1nc(Br)cc(NC)c1[N+](=O)[O-].COCCO>>CCc1cccc(C)c1CNc1nc(OCCOC)cc(NC)c1[N+](=O)[O-],,O,,[H-].[Na+],,val
US20130116249A1,COC(=O)c1cc(C(=O)c2c(C)c(OC)c3ccccn23)ccc1N.NN.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1c(C)c(C(=O)c2ccc3[nH]c(=O)n(N)c(=O)c3c2)n2ccccc12,,C1COCCO1,O,CCN(CC)CC,,val
US20130059830A1,Fc1ccc(-c2cc(C3CCCNC3)n(-c3ncccn3)n2)cc1.O=C=NCc1ccc(Cl)cc1>>O=C(NCc1ccc(Cl)cc1)N1CCCC(c2cc(-c3ccc(F)cc3)nn2-c2ncccn2)C1,,CN(C)C=O,,CS(C)=O,,val
US20040092546A1,O=C(Cl)OCc1ccccc1.c1c[nH]c(-c2n[nH]c3ncccc23)c1>>O=C(OCc1ccccc1)n1nc(-c2ccc[nH]2)c2cccnc21,CCN(CC)CC,ClCCl,,,,val
US05854239,COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1.ClCOCc1ccccc1>>COc1ccccc1CN1CN2CCCC1C2c1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20100056505A1,CCOC(=O)C(C(=O)c1ccc2ncnn2c1)c1cccc(C)c1.CNNC>>Cc1cccc(-c2c(-c3ccc4ncnn4c3)n(C)n(C)c2=O)c1,,c1ccncc1,,Cl,Cl,val
US06217869B1,COC(=O)CN(C)NC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21>>CN(CC(=O)O)NC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21,,CO,,[Na+].[OH-],,val
US20110034451A1,COc1c(N2CCOCC2)cc(C(=O)CBr)cc1C(C)(C)C.Cl.Nc1nnc2ccc(OCC3CC3)nn12>>COc1c(N2CCOCC2)cc(C(=O)Cn2nc3ccc(OCC4CC4)nn3c2=N)cc1C(C)(C)C.Cl,,CN(C)C=O,,,,val
US20080234306A1,CCCOS(=O)(=O)OCCC.COc1ccc(CO[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(OCc6ccccc6)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1>>CCCO[C@@]12CC[C@@H](OCc3ccc(OC)cc3)[C@@H]3Oc4c(OCc5ccccc5)ccc5c4[C@@]31CCN(CC1CC1)[C@@H]2C5,,CN(C)C=O,,O,[H-].[Na+],val
US20140343038A1,CC(C)(C)N.O=Cc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>CC(C)(C)n1cc2ccc([N+](=O)[O-])cc2n1,,CCO,,,,val
US20070179127A1,CC(C)(C)OC(=O)NC1CCN(S(=O)(=O)c2cccc3cncc(Br)c23)C1.OB(O)c1ccccc1>>CC(C)(C)OC(=O)NC1CCN(S(=O)(=O)c2cccc3cncc(-c4ccccc4)c23)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20130217680A1,CCOC(=O)c1coc2cc(N)ccc12>>COC(=O)C1COc2cc(N)ccc21,,CO,,,,val
US20130261100A1,CC(C)(C)O.O=C(O)C1(c2ccc(Br)cc2)CC1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)NC1(c2ccc(Br)cc2)CC1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US20040009976A1,CCOC(=O)Cc1c[nH]c2ccccc12.O=C1CCC(=O)N1Br>>CCOC(=O)Cc1c(Br)[nH]c2ccccc12,,ClCCl,,,,val
US04939253,CC(C)(C)C(=O)OCI.O=C(O)CON1C[C@H](NC(=O)OCc2ccccc2)C1=O>>CC(C)(C)C(=O)OCOC(=O)CON1C[C@H](NC(=O)OCc2ccccc2)C1=O,,CCOC(C)=O,CN(C)C=O,C1CCC2=NCCCN2CC1,,val
US20110245284A1,CCSC(C)c1cccc([N+](=O)[O-])c1>>CCSC(C)c1cccc(N)c1,[Pd],CO,,[H][H],,val
US20070249670A1,COC(=O)[C@H](COCC(C)(C)C)NC(=O)c1cc2ccccc2cc1N.Cc1cc(C)c(N=C=O)c(C)c1>>COC(=O)[C@H](COCC(C)(C)C)NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C,,c1ccncc1,,,,val
US20100009975A1,Nc1cc([N+](=O)[O-])c(F)cc1F.OCCS>>Nc1cc([N+](=O)[O-])c(F)cc1SCCO,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US04045209,CCCCNc1ccc(Cl)c(Cl)c1.CN=C=O>>CCCCN(C(=O)NC)c1ccc(Cl)c(Cl)c1,,CCN(CC)CC,,CC(C)OC(C)C,,val
US20020035102A1,CS(=O)(=O)C(=C1CN(C(c2ccc(Cl)cc2)c2ccc(C=O)cc2)C1)c1cc(F)cc(F)c1>>CS(=O)(=O)C(=C1CN(C(c2ccc(Cl)cc2)c2ccc(CO)cc2)C1)c1cc(F)cc(F)c1,,CO,,O,[BH4-].[Na+],val
US20070259965A1,CC(C)(C)OC(=O)NCCCN.O=S(=O)(Cl)c1ccc(F)cc1C(F)(F)F>>CC(C)(C)OC(=O)NCCCNS(=O)(=O)c1ccc(F)cc1C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20090286801A1,CC(C)(C)OC(=O)N1CCC(CCN2CCN(c3cccc(CO)c3)CC2)CC1.CI>>COCc1cccc(N2CCN(CCC3CCN(C(=O)OC(C)(C)C)CC3)CC2)c1,,CS(C)=O,,[H-].[Na+],,val
US05079260,COc1ccc2c(c1)C(CCC(=O)O)c1ccccc1-2.O=S(Cl)Cl>>COc1ccc2c(c1)C(CCC(=O)Cl)c1ccccc1-2,,CO,O,,,val
US20020099073A1,CCOC1(OCC)CCN([C@@H](C)c2ccccc2)[C@H](CN2C(=O)c3ccccc3C2=O)C1>>C[C@@H](c1ccccc1)N1CCC(=O)C[C@H]1CN1C(=O)c2ccccc2C1=O,,O,O=C(O)C(F)(F)F,O=C([O-])[O-].[Na+].[Na+],,val
US20030130213A1,N#Cc1nc(F)c[nH]c1=O.OO>>NC(=O)c1nc(F)cnc1O,,[Na+],[OH-],O,O=S(=O)(O)O,val
US20140303206A1,CCOC(=O)/C(=N\C(=O)OCc1ccccc1)C(F)(F)F>>CCOC(=O)[C@@H](NC(=O)OCc1ccccc1)C(F)(F)F,,CCOCC,,[BH4-].[Na+],,val
US20110070317A1,CC(C)(C)OC(=O)N1CC[C@H](F)[C@H](NC(=O)OCc2ccccc2)C1>>O=C(N[C@@H]1CNCC[C@@H]1F)OCc1ccccc1,,ClCCl,,C1COCCO1,Cl,val
US20070276000A1,CCOC(=O)C=C(Cc1cccc(OC)c1)C(C)C>>CCOC(=O)CC(Cc1cccc(OC)c1)C(C)C,[Pd],CCO,,[H][H],,val
US20070149514A1,CC(C)c1c[nH]c2ccc(Br)cc12.CCOC(=O)COc1ccc(S(=O)(=O)Cl)cc1C>>CCOC(=O)COc1ccc(S(=O)(=O)n2cc(C(C)C)c3cc(Br)ccc32)cc1C,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150072974A1,O=CCCCOc1ccc2ccc(=O)[nH]c2n1.c1ccc2c(c1)CCNC2>>O=c1ccc2ccc(OCCCCN3CCc4ccccc4C3)nc2[nH]1,,ClCCl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060178433A1,CCCCO.NC(CC(=O)O)c1cccc(F)c1>>CCCCOC(=O)CC(N)c1cccc(F)c1,,O,,O=S(=O)(O)O,[Na+].[OH-],val
US20060205765A1,Cc1ccc(C(=O)C(=CN(C)C)c2ccccc2)cc1.N#CCC(N)=O>>Cc1ccc(-c2[nH]c(=O)c(C#N)cc2-c2ccccc2)cc1,,CN(C)C=O,CO,Cl,[H-].[Na+],val
US20080051399A1,CC(C)N(C[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@H]3O)CC1)c1ccc(Cl)cc1)C(=O)OC(C)(C)C>>CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@H]3O)CC1)c1ccc(Cl)cc1,,C1COCCO1,CO,CCOCC,Cl,val
US20050288314A1,COc1ccc(Cl)cc1CO.N#Cc1c(F)cccc1F>>COc1ccc(Cl)cc1COc1cccc(F)c1C#N,,CN(C)C=O,,[H-].[Na+],,val
US05482913,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(OCc1ccccc1)c1ccc(O)cc1>>CC(C)(C)OC(=O)Oc1ccc(C(=O)OCc2ccccc2)cc1,,CCOC(C)=O,,c1ccncc1,,val
US03946009,CO.COc1nc(Br)cnc1N>>COc1cnc(N)c(OC)n1,,O,,[Na],,val
US05284945,CN(C1=CCN2C(=O)NS(=O)(=O)C2=C1)S(C)(=O)=O.COc1cc(OC)nc(N)n1>>COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ncccc2N(C)S(C)(=O)=O)n1,,ClCCl,,,,val
US20070208056A1,CC(C)[C@@H](N)C(=O)N1CCC(c2ccc(Cl)cc2)CC1.O=C(Cl)c1cccc(CCl)c1>>CC(C)[C@@H](NC(=O)c1cccc(CCl)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1,,ClCCl,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20100331293A1,C1COCCN1.Nc1cc(Br)cnc1F>>Nc1cc(N2CCOCC2)cnc1F,[Cu]I,CS(C)=O,,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US20090291917A1,CCOC(=O)c1nc(Cl)ccc1Br.O=Cc1cc(O)ccc1Br>>CCOC(=O)c1nc(Oc2ccc(Br)c(C=O)c2)ccc1Br,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150111885A1,CN(C(=O)OC(C)(C)C)c1cc(Br)cn(C)c1=O>>CNc1cc(Br)cn(C)c1=O,,ClCCl,,C1COCCO1,Cl,val
US04232107,CCCCCCCCCCCCCCCC(=O)c1c(O)cc(C)c(O)c1CCC>>CCCCCCCCCCCCCCCC(O)c1c(O)cc(C)c(O)c1CCC,,CO,O,[BH4-].[Na+],,val
US20060154926A1,COCCCBr.Oc1ccccc1O>>COCCCOc1ccccc1O,,CN(C)C=O,,[H-].[Na+],,val
US20160168090A1,CC1CCCC(O)(CNC(=O)c2c[nH]c3cccc(Cl)c23)C1.Cc1ccc(S(=O)(=O)OCC2CCCN2C(=O)OC(C)(C)C)cc1>>CC1CCCC(O)(CNC(=O)c2cn(CC3CCCN3)c3cccc(Cl)c23)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130303524A1,O=[N+]([O-])c1ccc(F)cc1Br.OB(O)c1ccccc1F>>O=[N+]([O-])c1ccc(F)cc1-c1ccccc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(=O)N(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20040242608A1,COC(=O)c1ccc(C)c(-n2c(SC)nc(OCc3ccc(F)cc3F)cc2=O)c1>>COC(=O)c1ccc(C)c(-n2cnc(OCc3ccc(F)cc3F)cc2=O)c1,[Ni],CC(=O)N(C)C,,,,val
US20130345123A1,O=C(N[C@H]1CCS[C@H]2CCCCN2C1=O)OCc1ccccc1>>N[C@H]1CCS[C@H]2CCCCN2C1=O,,ClCCl,,C[Si](C)(C)I,,val
US20140179667A1,COc1ccc2c(c1I)C(=O)N(Cc1c(C)cc(C)nc1OCc1ccccc1)CC2.N#C[Cu]>>COc1ccc2c(c1C#N)C(=O)N(Cc1c(C)cc(C)nc1OCc1ccccc1)CC2,,CCOC(C)=O,CN1CCCC1=O,O,,val
US20060116364A1,CC(C)(C)C(=O)N1CCSC1=S.CCNc1cc(OC)ccc1C1CCc2cc(O)ccc2C1>>CCNc1cc(OC)ccc1C1CCc2cc(OC(=O)C(C)(C)C)ccc2C1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20110269956A1,CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1ncc(-c2ccc3nc(-c4ccc5nc([C@@H]6C[C@H]7C[C@H]7N6C(=O)OC(C)(C)C)[nH]c5c4)cnc3c2)[nH]1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.c1cc2nc([C@@H]3C[C@H]4C[C@H]4N3)[nH]c2cc1-c1cnc2cc(-c3cnc([C@@H]4C[C@H]5C[C@H]5N4)[nH]3)ccc2n1,,ClCCl,,,,val
US20030040437A1,COC(=O)c1ccc(C(F)(F)F)nc1C.O=C1CCC(=O)N1Br>>COC(=O)c1ccc(C(F)(F)F)nc1CBr,,ClC(Cl)(Cl)Cl,,,,val
US20160075657A1,CCN=C=O.C[C@H](N)c1ccc(CN2CCc3cc(OCC4CC4(F)F)ccc3C2)cc1>>CCNC(=O)N[C@@H](C)c1ccc(CN2CCc3cc(OCC4CC4(F)F)ccc3C2)cc1,,C1CCOC1,,Cl,,val
US20110003807A1,CCOC(=O)c1sc(-c2c(C)nn3ccccc23)nc1OS(=O)(=O)C(F)(F)F.OB(O)c1ccc(F)cc1>>CCOC(=O)c1sc(-c2c(C)nn3ccccc23)nc1-c1ccc(F)cc1,,COCCOC,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20050222200A1,CC(C)(C)C[Mg]Cl.O=Cc1ccc(C(=O)O)cc1>>CC(C)(C)/C=C/c1ccc(C(=O)O)cc1,,C1CCOC1,CCCCCC,,,val
US06534546B1,CC(C)(C)OC(=O)NCc1cccc(NC(N)=S)c1.FCCBr>>CC(C)(C)OC(=O)NCc1cccc(NC(=N)SCCF)c1,,CC#N,,,,val
US20100210624A1,O=C(O)[C@H](O)[C@@H](O)C(=O)O.c1cnnc(-c2ccc3c(c2)CNCCC3Oc2ccc3ccccc3c2)c1>>O=C(O)C(O)C(O)C(=O)O.c1cnnc(-c2ccc3c(c2)CNCCC3Oc2ccc3ccccc3c2)c1,,CO,,O,,val
US20090054407A1,CC(C)(C)OC(=O)n1c(-c2ccc(O)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21.O=S(=O)(Cl)CC1CCCCC1>>CC(C)(C)OC(=O)n1c(-c2ccc(OS(=O)(=O)CC3CCCCC3)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21,,ClCCl,,CCN(CC)CC,,val
US20100144694A1,COCOc1ccc(N2N(C3C4CC5CC(C4)CC3C5)C(=O)C2(C)C)cc1>>CC1(C)C(=O)N(C2C3CC4CC(C3)CC2C4)N1c1ccc(O)cc1,,CO,,Cl,[Cl-].[NH4+],val
US20120263670A1,CN1Cc2c(Cl)cc(Cl)cc2C(c2ccc(N)cc2)C1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CN1Cc2c(Cl)cc(Cl)cc2C(c2ccc(NC(=O)Oc3ccc([N+](=O)[O-])cc3)cc2)C1,,ClCCl,,,,val
US03953442,CC(=O)Cc1c[nH]c2ccc(Cl)cc12.OCCO.c1ccccc1>>CC(Cc1c[nH]c2ccc(Cl)cc12)C1OCCO1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20030144280A1,NS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(O)c(Cl)c2)cn1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>NS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(OS(=O)(=O)C(F)(F)F)c(Cl)c2)cn1,CN(C)c1ccncc1,ClCCl,,,,val
US05969090,CCCCCCCCCCCCN(C)C.ClCCCBr>>CCCCCCCCCCCC[N+](C)(C)CCCCl.[Br-],,COC(C)(C)C,,CO,,val
US20020143035A1,O=C1[C@@H]2C[C@@H](O)CN2C(=O)N1c1cc(Cl)cc(Cl)c1>>O=C1C[C@H]2C(=O)N(c3cc(Cl)cc(Cl)c3)C(=O)N2C1,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20060116406A1,CCC(O)(CC)c1cnc(S)s1>>CCC(CC)c1cnc(S)s1,,CCOC(C)=O,ClCCl,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20130197033A1,CC(C)(C)OC(=O)N1CC[C@@H](c2ccc(F)cc2)[C@H](COc2ccc3c(c2)COC3)C1>>Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)COC3)cc1,,Cc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,val
US20150315198A1,O=S(Cl)Cl.OCc1ccc(Cn2cccn2)cc1>>ClCc1ccc(Cn2cccn2)cc1,,ClCCl,,,,val
US04522948,CCCCC(COS(C)(=O)=O)CC1CCCCC1.[C-]#N>>CCCCC(CC#N)CC1CCCCC1,,CN(C)C=O,,O,,val
US20090093454A1,C=O.CN1CCN(c2cccc3nc(CN4CCC[C@H]5CCc6cccnc6[C@H]54)cn23)CC1.CN1CCNCC1>>CN1CCN(Cc2c(CN3CCC[C@H]4CCc5cccnc5[C@H]43)nc3cccc(N4CCN(C)CC4)n23)CC1,,O,,CC(=O)O,,val
US20100317693A1,Cl.Cn1cc(C[C@@H](NC(=O)C(C)(C)N)C(=O)NC2Cc3cccc(N4CCCC4=O)c3N(Cc3ccsc3)C2=O)c2ccccc21>>Cl.Cn1cc(C[C@@H](NC(=O)C(C)(C)N)C(=O)NC2Cc3cccc(N4CCCC4=O)c3N(Cc3ccsc3)C2=O)c2ccccc21,,CCO,,,,val
US20020049210A1,Cc1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1.O=CC=CC1CCN(Cc2ccccc2)CC1>>Cc1ccc2cc(C(=CC3CCN(Cc4ccccc4)CC3)CO)n(S(=O)(=O)c3ccccc3)c2c1,,C1CCCCC1,C1CCOC1,CC(C)[N-]C(C)C.[Li+],,val
US04160021,CC(=O)c1c(O)oc(=O)c(C(C)=O)c1O.CCONC(=O)c1cc(C(=O)NOCC)cc([N+](=O)[O-])c1>>CCONC(=O)c1cc(NC(C)=C2C(=O)OC(=O)C(C(C)=O)=C2O)cc(C(=O)NOCC)c1,[Pd],CCO,,,,val
US04255428,COc1ccnc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)c1.Cc1[nH]cnc1CSCCN>>COc1ccnc(Cc2cnc(NCCSCc3nc[nH]c3C)[nH]c2=O)c1,,CC(C)O,,CCO,,val
US05683994,COC(=O)CCc1ccc(OC)c(OC)c1.O=C1CCC(=O)N1Br>>COC(=O)C(Br)Cc1ccc(OC)c(OC)c1,,C1CCOC1,,C[Si](C)(C)Cl,,val
US04225521,CC(C)OC(=O)C(Cl)(Cl)P(=O)(OC(C)C)c1ccccc1>>CC(C)OC(=O)C(Cl)P(=O)(OC(C)C)c1ccccc1,,CCCCCC,CCOCC,Cl,[Li]CCCC,val
US20060211680A1,COC(=O)CS.O=Cc1cccc(CBr)c1>>COC(=O)CSCc1cccc(C=O)c1,,CCOCC,,CCO,O=C([O-])[O-].[K+].[K+],val
US20060052396A1,CN(C)Cc1ccncc1NC(=O)OC(C)(C)C>>CN(C)Cc1ccncc1N,,ClCCl,,O=C(O)C(F)(F)F,,val
US05244889,CCOC(=O)C1CCCCCCC(O)(C[Si](C)(C)C)C(=O)N1>>C=C1CCCCCCC(C(=O)OCC)NC1=O,,ClCCl,,CCOCC,FB(F)F,val
US03956277,CSc1nc(NC(C)=O)nc2nc[nH]c12.Cl[C@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1>>CSc1nc(NC(C)=O)nc2c1ncn2[C@@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1,,CC#N,,CCN(CC)CC,,val
US20090062360A1,BrBr.COc1ccc(C2=NC3(CCCCC3)NC2=O)cc1>>COc1ccc(C2=NC3(CCCCC3)NC2=O)cc1Br,,ClCCl,,,,val
US06147110,COc1ccc2c(c1)C(=O)CO2.O=Cc1ccccc1>>COc1ccc2c(c1)C(=O)C(=Cc1ccccc1)O2,,ClCCl,,,,val
US20100069383A1,COc1ccc(N(C)c2nc(CN)nc3ccccc23)cc1.O=C(Cl)c1cccnc1>>COc1ccc(N(C)c2nc(CNC(=O)c3cccnc3)nc3ccccc23)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20090270374A1,CO.O=C1CCc2c(Cl)nc(/C=C/c3ccccc3)nc2N1>>COc1nc(/C=C/c2ccccc2)nc2c1CCC(=O)N2,,CO,,C[O-].[Na+],,val
US20030203128A1,CC(=O)OC(C)=O.CC(=O)c1ccc2c(c1)C(C)c1cc(C(C)=O)ccc1-2.OO>>CC(=O)Oc1ccc2c(c1)C(C)c1cc(OC(C)=O)ccc1-2,,ClCCl,O,O=S(=O)(O)O,,val
US20050256140A1,C[Si](C)(C)C=[N+]=[N-].Cn1cnc(-c2ccccc2)c1C=O>>C#Cc1c(-c2ccccc2)ncn1C,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20100279868A1,CC(C)(C)C(=O)Cl.CCc1sc(-c2ccc(Cl)cc2)nc1C1C(=O)C(C)(C)OC(C)(C)C1=O>>CCc1sc(-c2ccc(Cl)cc2)nc1C1=C(OC(=O)C(C)(C)C)C(C)(C)OC(C)(C)C1=O,,ClCCl,,CCN(CC)CC,,val
US20050176701A1,CC(=O)OC(C)=O.Cc1n[nH]c(C)c1I>>CC(=O)n1nc(C)c(I)c1C,,ClCCl,,CCN(CC)CC,,val
US20140275154A1,CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(CCC(F)(F)F)c(-c3cccc(C(=O)OC(C)(C)C)c3)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(CCC(F)(F)F)c(-c3cccc(C(=O)O)c3)cc12,,CC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20090196912A1,O=C(Cc1cccc(O)c1)Nc1cncc(-c2cccc(O)c2)c1>>Oc1cccc(CCNc2cncc(-c3cccc(O)c3)c2)c1,,C1CCOC1,,,,val
US20050245399A1,COc1cc(-c2nn(C)c(OC(F)F)c2Cl)c(F)cc1Cl.O=[N+]([O-])O>>COc1c(Cl)cc(F)c(-c2nn(C)c(OC(F)F)c2Cl)c1[N+](=O)[O-],,O,,O=S(=O)(O)O,,val
US20060217372A1,CCCCCN.NC(=O)c1ccc(Oc2ccc(C=O)c(F)c2F)nc1>>CCCCCNCc1ccc(Oc2ccc(C(N)=O)cn2)c(F)c1F,,CO,,[BH4-].[Na+],,val
US04666915,CCOC(=O)c1cnc(SC)[nH]c1=O.CCOc1ccccc1N>>CCOC(=O)c1cnc(Nc2ccccc2OCC)[nH]c1=O,,CCO,,,,val
US20060183736A1,CS(=O)(=O)c1ccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1.O=C(Cl)c1ccc(F)cc1>>CS(=O)(=O)c1ccc(-c2ccc3cc(OC(=O)c4ccc(F)cc4)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US06291475B1,CC(C)(C)OC(=O)N1CC2CNCC(C2)C1.N#Cc1ccc(OCC=CCCl)cc1>>CC(C)(C)OC(=O)N1CC2CC(CN(CC=CCOc3ccc(C#N)cc3)C2)C1,,CC#N,,,,val
US20160229814A1,CCNC(=O)c1cc(Br)cc(F)c1N.O=C(Cl)Cl>>CCn1c(=O)[nH]c2c(F)cc(Br)cc2c1=O,,C1CCOC1,,Cc1ccccc1,,val
US05424414,COC(=O)CC(=O)CCCCCNC(=O)OCc1ccccc1>>O=C(NCCCCCC(O)CCO)OCc1ccccc1,,C1CCOC1,,CO,,val
US03965173,COC(=O)c1cc(Cl)ccc1O.COS(=O)(=O)OC>>COc1ccc(Cl)cc1C(=O)O,,CC(C)=O,,[Na+].[OH-],,val
US20050187209A1,CCOC(=O)n1nc(NC(=O)c2ccc(N3CCOCC3)cc2)c2cc(C(=O)OC(C)(C)C)sc21.Cl>>CCOC(=O)n1nc(NC(=O)c2ccc(N3CCOCC3)cc2)c2cc(C(=O)O)sc21.Cl,,C1COCCO1,,,,val
US20040220225A1,Clc1nc2ccccc2s1.NCCN1CCCCC1>>c1ccc2sc(NCCN3CCCCC3)nc2c1,,CCO,,CCN(CC)CC,,val
US20080090813A1,CCCC(=O)C(C)C(=O)c1cccc(C(F)(F)F)c1.NC(N)=O>>CCCc1[nH]c(=O)nc(-c2cccc(C(F)(F)F)c2)c1C,,CCO,,Cl,,val
US20030060467A1,CC(=O)c1[nH]nc(OS(=O)(=O)c2ccc(C)cc2)c1-c1ccccc1F.NNC(=O)c1ccccc1>>Cc1ccc(S(=O)(=O)Oc2nn3c(-c4ccccc4)nnc(C)c3c2-c2ccccc2F)cc1,,Cc1ccccc1C,,,,val
US20060247251A1,CC(=O)OC(C)=O.N#Cc1ncc2cc(CN3CCC4(CCNC4)CC3)n(CCC3CCCCC3)c2n1>>CC(=O)N1CCC2(CCN(Cc3cc4cnc(C#N)nc4n3CCC3CCCCC3)CC2)C1,,c1ccncc1,,O=C(O)C(F)(F)F,,val
US20110275637A1,O=C(Oc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1.OCCc1ccncc1>>O=C(OCCc1ccncc1)Oc1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,ClCCl,CN1CCOCC1,,val
US20160158377A1,COC(=O)c1ccc(Br)c(CBr)c1.C[Si](C)(C)C#N>>COC(=O)c1ccc(Br)c(CC#N)c1,,CC#N,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20120238452A1,CN(C)N=C1CCN(N(C)C)CC1.C[Si](C)(C)C#N>>CN(C)NC1(C#N)CCN(N(C)C)CC1,,O,,,,val
US04463173,N#CCc1ccc(N)c([N+](=O)[O-])c1>>N#CCc1ccc(N)c(N)c1,[Pd],CCO,,,,val
US20040248872A1,CC(CCCCCS(=O)(=O)[O-])=C(F)F.O=C(O)c1ccc2[nH]ccc2c1>>CC(CCCCOC(=O)c1ccc2[nH]ccc2c1)=C(F)F,,O,,CN(C)C=O,O=C([O-])O.[Na+],val
US20110237584A1,FC(F)(F)C(Oc1nc2ccccc2nc1Cl)c1cccnc1.N#Cc1ccccc1S(N)(=O)=O>>N#Cc1ccccc1S(=O)(=O)Nc1nc2ccccc2nc1OC(c1cccnc1)C(F)(F)F,,CC(=O)O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US06881733B1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1(C)CN(Cc2ccccc2)CCC1=O>>CC(C)(C)OC(=O)N1CCC(=O)C(C)(C)C1,[Pd],CO,,,,val
US20070265281A1,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N(CC(=O)O)CC1CCCCC1.N[C@]1(C(=O)NS(=O)(=O)c2cccc3cc[nH]c23)C[C@H]1C1CC1>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N(CC(=O)N[C@]1(C(=O)NS(=O)(=O)c2cccc3cc[nH]c23)C[C@H]1C1CC1)CC1CCCCC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100266714A1,C#Cc1cc(C(=O)OC)cc(-c2ccc(C)cn2)c1.C[Si](C)(C)CN=[N+]=[N-]>>COC(=O)c1cc(-c2ccc(C)cn2)cc(-c2cnnn2C[Si](C)(C)C)c1,,c1ccccc1,,,,val
US05089627,COc1cc(OC)nc(S(C)(=O)=O)n1.CSc1n[nH]c(=O)n1N>>COc1cc(OC)nc(-n2nc(SC)n(N)c2=O)n1,Cc1ccc(S(=O)(=O)O)cc1,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110218188A1,CC(=O)c1cc(-c2ncnc(Nc3cccc(Cl)c3)n2)ccn1.CON>>CO/N=C(\C)c1cc(-c2ncnc(Nc3cccc(Cl)c3)n2)ccn1,,CCO,,Cl,CC(=O)[O-].[Na+],val
US06350749B1,CC(O)=C1C(=O)CC(c2ccccc2Cl)CC1=O.NN>>Cc1n[nH]c2c1C(=O)CC(c1ccccc1Cl)C2,,CCO,,O,,val
US20040157886A1,Nc1ccc([N+](=O)[O-])cc1.O=C(O)C(=O)N1CCC(Cc2ccc(F)cc2)CC1>>O=C(Nc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC(Cc2ccc(F)cc2)CC1,,CCOCC,,,,val
US20100310512A1,COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc3c(c2)sc2cc(-c4cnc(C5CCCN5C(=O)C(NC(=O)OC)C(C)C)[nH]4)ccc23)[nH]1)C(C)C.O=C(OO)c1cccc(Cl)c1>>COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc3c(c2)S(=O)c2cc(-c4cnc(C5CCCN5C(=O)C(NC(=O)OC)C(C)C)[nH]4)ccc2-3)[nH]1)C(C)C,,CCOC(C)=O,ClCCl,,,val
US05977410,NCCOc1ccc(OC(F)(F)C(F)Cl)cc1.O=C(Cl)c1c(F)cccc1F>>O=C(NCCOc1ccc(OC(F)(F)C(F)Cl)cc1)c1c(F)cccc1F,,CCN(CC)CC,,C1CCOC1,,val
US20040092582A1,CC(=O)OC(C)=O.COC(=O)c1cc(-c2cccc(C3=NC(C)(C)Cc4cc(OC)c5c(c43)CC(C)(C)O5)c2)ccc1N>>COC(=O)c1cc(-c2cccc(C3=NC(C)(C)Cc4cc(OC)c5c(c43)CC(C)(C)O5)c2)ccc1NC(C)=O,,O,,,,val
US20050171130A1,CC#CCO.CC(Oc1cc(Cl)ncn1)C1CC1>>CC#CCOc1cc(OC(C)C2CC2)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US04686227,COS(=O)(=O)OC.Cc1nc2c3ccccc3ccn2c1CN(C)C>>COS(=O)(=O)[O-].Cc1nc2c3ccccc3ccn2c1C[N+](C)(C)C,,C1CCOC1,,CCOCC,,val
US20140228372A1,CC(C)(C)OC(=O)N1CCC(C(=O)CBr)CC1.NC(N)=S>>CC(C)(C)OC(=O)N1CCC(c2csc(N)n2)CC1,,CC(C)O,,O=C([O-])[O-].[Na+].[Na+],,val
US20070066618A1,O=C(O[C@@H]1C[C@@H](c2ccccc2)C1)c1ccccc1.O=[N+]([O-])O>>O=[N+]([O-])c1ccc([C@H]2C[C@H](O)C2)cc1,,CC(=O)OC(C)=O,,O=S(=O)(O)O,,val
US20130005705A1,CCOC(=O)C(F)(F)c1ccc2ccccc2n1>>OCC(F)(F)c1ccc2ccccc2n1,,CCO,,[BH4-].[Na+],,val
US05488140,CCOC(=O)C(N)C=C(CCCCO)CP(=O)(O)O>>NC(C=C(CCCCO)CP(=O)(O)O)C(=O)O,,O,,,,val
US20070232649A1,COc1ccc(O)c(C=O)c1.Nc1cc(NS(=O)(=O)CC(=O)O)ccc1F>>COc1ccc2oc(=O)c(S(=O)(=O)Nc3ccc(F)c(N)c3)cc2c1,,CC(=O)O,,,,val
US20090082328A1,CC1(C)OC[C@H](CCOc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)O1>>NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1OCC[C@H](O)CO,,C1CCOC1,,Cl,,val
US20100234390A1,O=C(O)CC(=O)O.O=Cc1ccc([N+](=O)[O-])o1>>O=C(O)C=Cc1ccc([N+](=O)[O-])o1,,O,c1ccncc1,C1CCNCC1,Cl,val
US20110098324A1,CC(C)N.CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(C2CCCCC2)c1=O>>CC(C)NC(=O)c1c(O)c(C(=O)NCC(=O)O)c(=O)n(C2CCCCC2)c1O,,ClC(Cl)Cl,,,,val
US20100249191A1,COC1CCC(OC)O1.Nc1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1>>FC(F)(F)C1(c2cc(Cl)cc(Cl)c2)CC(c2ccc(-n3cccc3)cc2)=NO1,,CC(=O)O,,CCOC(C)=O,O,val
US20110275638A1,CC(C)CCN.C[C@@](Cc1ccc(O)cc1)(NC(=O)OCc1ccncc1)C(=O)O>>CC(C)CCNC(=O)[C@](C)(Cc1ccc(O)cc1)NC(=O)OCc1ccncc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US04073770,CC1=CC(C)(C)Nc2cc(C)ccc21>>CC1CCC2C(C)CC(C)(C)NC2C1,[Rh],,,[H][H],,val
US06015774,COc1cc(I)c(F)cc1Cl.O=C[O-]>>COc1cc(C=O)c(F)cc1Cl,,CN(C)C=O,,Cl,,val
US03976653,CCOC(=O)[C@H]1CCCN(C(=O)OCc2ccccc2)[C@H]1Cc1ccc(OC)cc1>>COc1ccc(C[C@H]2[C@@H](CO)CCCN2C)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130072470A1,CN[C@H]1C[C@@H](C)[C@@H](c2cnc3cnc4[nH]ccc4n23)C1.O=C(O)c1cocn1>>C[C@@H]1C[C@H](N(C)C(=O)c2cocn2)C[C@@H]1c1cnc2cnc3[nH]ccc3n12,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20090137548A1,Brc1csc(Br)n1.C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1cc(C(F)(F)F)ccc1B1OC(C)(C)C(C)(C)O1>>C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1cc(C(F)(F)F)ccc1-c1nc(Br)cs1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20130244891A1,BrCCBr.O=[N+]([O-])c1ccccc1O>>O=[N+]([O-])c1ccccc1OCCBr,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050026942A1,NCc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)cc1.O=C=NCc1ccccc1>>O=C(NCc1ccccc1)NCc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)cc1,,ClCCl,,,,val
US20030114508A1,COCCNC1=C(NC(C)=O)C(=O)c2ccccc2C1=O>>COCCn1c(C)nc2c1C(=O)c1ccccc1C2=O,,CCO,,O,[Na+].[OH-],val
US20080188452A1,CC(C)(C)OC(=O)N1CCCC2CN(c3nc(N)nc4c3CCCc3ccccc3-4)CC21>>Nc1nc2c(c(N3CC4CCCNC4C3)n1)CCCc1ccccc1-2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140057914A1,CCOC(=O)C(=O)Cl.N/C(=N/O)c1ccc(OC(F)(F)F)cc1>>CCOC(=O)c1nc(-c2ccc(OC(F)(F)F)cc2)no1,,ClC(Cl)Cl,,c1ccncc1,,val
US20070191289A1,CC(C)(C)C(=O)OC[C@H]1O[C@@H](Oc2n[nH]c3nccc(CCc4ccc(OC(=O)C(C)(C)C)cc4)c23)[C@H](OC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@@H]1OC(=O)C(C)(C)C.CN(C)CCO>>CN(C)CCn1nc(O[C@@H]2O[C@H](COC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@H](OC(=O)C(C)(C)C)[C@H]2OC(=O)C(C)(C)C)c2c(CCc3ccc(OC(=O)C(C)(C)C)cc3)ccnc21,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150274665A1,CCc1[nH]cc(C(Cl)C(F)(F)F)c(=O)c1O.CNC>>CCc1[nH]cc(C(N(C)C)C(F)(F)F)c(=O)c1O,,CC#N,,Cl,,val
US04634710,COc1ccnc(CSc2nc3cc4c(cc3[nH]2)OCO4)c1C.O=C(OO)c1cccc(Cl)c1>>COc1ccnc(CS(=O)c2nc3cc4c(cc3[nH]2)OCO4)c1C,,ClC(Cl)Cl,,,,val
US20110105508A1,Cc1cccc2cc(C=O)c(-c3ccccc3)nc12.[Li]C>>Cc1cccc2cc(C(C)O)c(-c3ccccc3)nc12,,C1CCOC1,,,,val
US20080255155A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cccc(Oc2ccc([N+](=O)[O-])nc2)c1>>CC(C)(C)OC(=O)Nc1cccc(Oc2ccc([N+](=O)[O-])nc2)c1,,C1CCOC1,,,,val
US20040127574A1,CC(C)(C)[Si](C)(C)OCc1cccc2c1C=CCCCC2>>OCc1cccc2c1C=CCCCC2,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20060154917A1,CCCCn1c(-c2c(C)cccc2C)nc(Cl)c1CN1CCCCC1c1ccc(C(N)=O)c(OC)c1>>CCCCn1c(-c2c(C)cccc2C)nc(Cl)c1CN1CCCCC1c1ccc(C(N)=O)c(O)c1,,ClCCl,,BrB(Br)Br,O,val
US20070219222A1,CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cn1c(=O)c2c(ncn2CC(=O)O)n(C)c1=O.Nc1ccccc1>>CC(C)c1ccc(NC(=O)Cn2cnc3c2c(=O)n(C)c(=O)n3C)cc1,CN(C)c1ccncc1,CN(C)C=O,ClCCl,,,val
US20050043368A1,CC(C)(C)C=O.FC(F)(F)c1ccc2scnc2c1>>CC(C)(C)C(O)c1nc2cc(C(F)(F)F)ccc2s1,,C1CCOC1,CCCCCC,O,[Li]CCCC,val
US20110201629A1,CC1(C)C(=O)Nc2ncccc21.Cc1ncc(Cl)cc1C(=O)N[C@@H]1CC[C@@H](COS(C)(=O)=O)CC1>>Cc1ncc(Cl)cc1C(=O)N[C@@H]1CC[C@@H](CN2C(=O)C(C)(C)c3cccnc32)CC1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US05155240,CC=CC(C)=COC.COC(=O)C=O>>COC(=O)C1OC(OC)C(C)=CC1C,,O=C([O-])O,[Na+],,,val
US20080004261A1,CN.O=C(O)CC(S)C(=O)O.O=Cc1ccccc1>>CN1C(=O)C(CC(=O)O)SC1c1ccccc1,,CN(C)C=O,O,Cl,,val
US20160016936A1,CC(C)(C)OC(=O)N1CC(CI)C1.Cc1cc(-c2c[nH]c([C@H]3CCN(C(=O)OCc4ccccc4)C[C@H]3F)n2)ccc1F>>Cc1cc(-c2cn(CC3CN(C(=O)OC(C)(C)C)C3)c([C@H]3CCN(C(=O)OCc4ccccc4)C[C@H]3F)n2)ccc1F,,CN(C)C=O,,[H-].[Na+],,val
US20140249126A1,CCOC=C(C(=O)OCC)C(=O)OCC.COc1ccc(N)c(F)c1OC>>CCOC(=O)C(=CNc1ccc(OC)c(OC)c1F)C(=O)OCC,,CCO,,,,val
US20120171199A1,CC(c1nc2c(N3CCOCC3)nc(Cl)nc2n1C1CCCCO1)N(C)C(=O)OC(C)(C)C>>CNC(C)c1nc2c(N3CCOCC3)nc(Cl)nc2[nH]1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20040014745A1,CS(=O)(=O)Cl.O=C(NC1CCNCC1)c1ccc(F)cc1>>CS(=O)(=O)N1CCC(NC(=O)c2ccc(F)cc2)CC1,,ClCCl,,O,c1ccncc1,val
US05081271,C[Si](C)(C)c1cccc(CBr)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[Si](C)(C)c1cccc(C[PH3+])c1.[Br-],,Cc1ccccc1,,,,val
US05962002,CCOC(=O)CCCC(C)(C)C>>CC(C)(C)CCCCO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20100075946A1,CI.O=C(O)c1cc(-c2ccccc2)cs1.[Li]CCCC>>CCc1sc(C(=O)O)cc1-c1ccccc1,,C1CCOC1,,,,val
US20100039688A1,COc1cc2c(cc1OC)C1OCC(c3ccccc3)(c3ccc(N4CCCC4)cc3)C=C1C=C2c1ccc(-c2ccc(O)cc2)cc1.O=C(O)c1ccc(F)cc1F>>COc1cc2c(cc1OC)C1OCC(c3ccccc3)(c3ccc(N4CCCC4)cc3)C=C1C=C2c1ccc(-c2ccc(OC(=O)c3ccc(F)cc3F)cc2)cc1,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100004308A1,CI.Fc1cc2cc[nH]c2cc1I>>Cn1ccc2cc(F)c(I)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20090247534A1,CCOC(=O)CC1CCC(c2ccc(C(=O)CN=[N+]=[N-])cc2)CC1.S=C=Nc1cccc(Cl)c1>>CCOC(=O)CC1CCC(c2ccc(-c3cnc(Nc4cccc(Cl)c4)o3)cc2)CC1,,C1COCCO1,CCOC(C)=O,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090163508A1,CC(C)(C)OC(=O)N1CCN(c2cncc(-c3ccc(F)cc3F)n2)CC1>>Fc1ccc(-c2cncc(N3CCNCC3)n2)c(F)c1,,CCOC(C)=O,,Cl,,val
US06967201B1,CC(C)(C)OC(=O)N1CCN(c2cc(CO[Si](C)(C)C(C)(C)C)cc3ccoc23)CC1>>CC(C)(C)OC(=O)N1CCN(c2cc(CO)cc3ccoc23)CC1,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US04328341,C=CCBr.CC(=O)c1cc(C(C)=O)c(O)cc1N>>C=CCOc1cc(N)c(C(C)=O)cc1C(C)=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080194629A1,CC(C)(C)OC(=O)N1CCCC(C=O)C1.NCC1(CCc2ccccc2)c2ccccc2Oc2ccccc21>>CC(C)(C)OC(=O)N1CCCC(C(=O)NCC2(CCc3ccccc3)c3ccccc3Oc3ccccc32)C1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100331326A1,Cc1cc(Cl)ccc1Br.Cc1ccncc1N1CCNC1=O>>Cc1cc(Cl)ccc1N1CCN(c2cnccc2C)C1=O,I[Cu]I,C1COCCO1,,N[C@@H]1CCCC[C@H]1N,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20060247251A1,CO[C@@H]1CCNC1.Cc1nc(C#N)nc2c1cc(Br)n2CCC1CCCCC1>>CO[C@@H]1CCN(Cc2cc3cnc(C#N)nc3n2CCC2CCCCC2)C1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20080132477A1,C=CCBr.COC(=O)c1cc(C)cc(O)c1>>C=CCOc1cc(C)cc(C(=O)OC)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05578620,C[C@@H](COc1ccc(CC2SC(=O)N(C(c3ccccc3)(c3ccccc3)c3ccccc3)C2=O)cc1)N1C[C@H](COc2cccc(Cl)c2)OC1=O>>C[C@@H](COc1ccc(CC2SC(=O)NC2=O)cc1)N1C[C@H](COc2cccc(Cl)c2)OC1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020177591A1,C1CN2CCC(CC2)N1.O=C(Cl)Oc1ccccc1>>O=C(Oc1ccccc1)N1CCN2CCC1CC2,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20130102776A1,CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2OCC3=O)CC1.OCc1ccccc1>>CC(C)(C)OC(=O)N1CCN(Cc2c(OCc3ccccc3)ccc3c2OCC3=O)CC1,,Cc1ccccc1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140350019A1,COC(=O)c1cc(Br)cc(OC)c1.OB(O)c1cccc(F)c1>>COC(=O)c1cc(OC)cc(-c2cccc(F)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CO,,,val
US05665754,C=C(C(=O)OC)c1ccc(OC)c(OC2CCCC2)c1.COCN(Cc1ccccc1)C[Si](C)(C)C>>COC(=O)C1(c2ccc(OC)c(OC3CCCC3)c2)CCN(Cc2ccccc2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140200216A1,C[C@H]1CN(c2ccncc2NC(=O)c2nc3cc(N4CCN(C)CC4)ccc3cc2NC(=O)OCc2ccccc2)C[C@@H](NC(=O)OC(C)(C)C)[C@H]1n1ccnn1>>C[C@H]1CN(c2ccncc2NC(=O)c2nc3cc(N4CCN(C)CC4)ccc3cc2N)C[C@@H](N)[C@H]1n1ccnn1,[Pd],C1CCOC1,CO,C1COCCO1,Cl,val
US20150065482A1,II.c1cnc2cn[nH]c2c1>>Ic1n[nH]c2cccnc12,,CN(C)C=O,O,[K+].[OH-],,val
US20060148858A1,CCOC(=O)CCc1ccc(O)c(OCc2ccccc2)c1.CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO>>CCOC(=O)CCc1ccc(OCCCc2cn(-c3ccc(C(F)(F)F)cn3)nc2OCC)c(OCc2ccccc2)c1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20050191229A1,Brc1ccc2c(c1)Cc1ccccc1-2.COCCOS(C)(=O)=O>>COC1(OC)c2ccccc2-c2cccc(CCBr)c21,,O,,C1CCOC1,CC(C)(C)[O-].[K+],val
US20140094459A1,CCOC(=O)C(C)(C)N(CC)C(=O)OC(C)(C)C>>CCN(C(=O)OC(C)(C)C)C(C)(C)CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060154105A1,CC(=O)c1ccc(Br)cc1.Nc1ccccn1>>Brc1ccc(-c2cn3ccccc3n2)cc1,,CCO,,[Na+].[OH-],,val
US20050054733A1,Cc1c(F)ccc(C#N)c1F>>Cc1c(F)ccc(CN)c1F,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05110812,CC(C)(C)[Si](C)(C)N1C(=O)[C@@H](CCCNC(=NC(=O)OCc2ccccc2)NC(=O)OCc2ccccc2)[C@H]1C=Cc1ccccc1.O=[O+][O-]>>CC(C)(C)[Si](C)(C)N1C(=O)[C@@H](CCCNC(=NC(=O)OCc2ccccc2)NC(=O)OCc2ccccc2)[C@H]1C=O,,ClCCl,,,,val
US09181233B2,CN(C)C=O.N=C(NO)c1ccc2nc[nH]c2c1.O=C(n1ccnc1)n1ccnc1>>CN(C)C=NNC(=O)c1ccc2[nH]cnc2c1,,CN(C)C=O,O,O=C([O-])O.[Na+],,val
US20070155737A1,CO.O=C(NCc1ccc(F)c(F)c1)c1cc(C(=O)O)n2nccc2n1>>COC(=O)c1cc(C(=O)NCc2ccc(F)c(F)c2)nc2ccnn12,,CO,c1ccccc1,C[Si](C)(C)C=[N+]=[N-],,val
US05618941,CS(=O)[O-].O=C(O)CCc1cc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc(C(=O)c2ccc(F)cc2)c1>>CS(=O)(=O)c1ccc(C(=O)c2cc(CCNS(=O)(=O)c3ccc(Cl)cc3)cc(CCC(=O)O)c2)cc1,,CS(C)=O,O,Cl,,val
US05387603,CC(=O)N1CCc2cc(C[C@@H](C)NCCOc3ccccc3OCC(F)(F)F)cc(C#N)c21.O=C([O-])O>>CC(=O)N1CCc2cc(C[C@@H](C)NCCOc3ccccc3OCC(F)(F)F)cc(C(N)=O)c21,,CC(C)O,,Cl,,val
US20080280876A1,CC(C)Oc1ccc(-c2noc(-c3ccc(S(=O)(=O)NCCC(=O)OC(C)(C)C)cc3)n2)cc1Cl>>CC(C)Oc1ccc(-c2noc(-c3ccc(S(=O)(=O)NCCC(=O)O)cc3)n2)cc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110092479A1,CI.COc1ccc(Cn2nc(O)c3cc(Br)cnc32)cc1>>COc1ccc(Cn2nc(OC)c3cc(Br)cnc32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20030195356A1,Clc1ccc2[nH]cc(C3CCNCC3)c2c1.O=C(O)c1csc2ccc([N+](=O)[O-])cc12>>NC(=O)c1csc2ccc([N+](=O)[O-])cc12,,C1CCOC1,,CCN(CC)CC,,val
US07148221B2,CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4N)ncn3)cccc2s1.O=C(O)CC1CCCCC1>>CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4NC(=O)CC4CCCCC4)ncn3)cccc2s1,CN(C)C=O,CC(C)=O,ClCCl,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US20050014748A1,NCC1CCN(C(c2ccccc2)c2ccccc2)C1.O=C(O)CC(c1ccccc1)c1ccccc1>>O=C(CC(c1ccccc1)c1ccccc1)NCC1CCN(C(c2ccccc2)c2ccccc2)C1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20140155407A1,CC(O)c1ccc(-c2ccsc2)nc1.O=C(n1ccnc1)n1ccnc1>>CC(c1ccc(-c2ccsc2)nc1)n1ccnc1,,CN1CCCC1=O,,,,val
US20090130076A1,Cn1nccc1C(O)c1cc(-c2ccc3c(c2)OCO3)c2nc(NC(=O)OC(C)(C)C)sc2c1>>Cn1nccc1C(O)c1cc(-c2ccc3c(c2)OCO3)c2nc(N)sc2c1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20030166826A1,CC(C)=O.Oc1ccccc1.Oc1ccccc1>>CC(C)(c1ccc(O)cc1)c1ccc(O)cc1,,CC(C)=O,,,,val
US20020111364A1,ClCc1cc(Cl)cc2c1OCOC2.O=[N+]([O-])c1ccccc1O>>O=[N+]([O-])c1ccccc1OCc1cc(Cl)cc2c1OCOC2,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160060237A1,CCC(Oc1ccc(C(C)=O)cc1[N+](=O)[O-])c1ccccc1.CCOC(=O)CP(=O)(OCC)OCC>>CCOC(=O)C=C(C)c1ccc(OC(CC)c2ccccc2)c([N+](=O)[O-])c1,,C1CCOC1,,[H-].[Na+],,val
US20140045746A1,Cc1cc(OCCCS(C)(=O)=O)ncc1-c1ccc(F)c(C(=O)O)c1>>Cc1cc(OCCCS(C)(=O)=O)ncc1-c1ccc(F)c(CO)c1,,C1CCOC1,,CO,,val
US05543409,CCC=O.NCC1Cc2ccc(C3=NNC(=O)CC3)cc2C1>>CCCNCC1Cc2ccc(C3=NNC(=O)CC3)cc2C1,,CO,,[BH4-].[Na+],,val
US04160837,O=C(OCC(Cl)(Cl)Cl)N1CC2OC2C1.Oc1ccccc1>>O=C(OCC(Cl)(Cl)Cl)N1C[C@@H](O)[C@H](Oc2ccccc2)C1,,CC#N,O,[Na+].[OH-],,val
US20100121048A1,CCOC(=O)c1cc[nH]c1-c1ccccc1.COc1cccc(CBr)c1>>CCOC(=O)c1ccn(Cc2cccc(OC)c2)c1-c1ccccc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20120129872A1,BrC(Br)(Br)Br.CC(=O)c1ccc2c(c1)nc(CO)n2C>>CC(=O)c1ccc2c(c1)nc(CBr)n2C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150344490A1,CC(=O)CCl.Nc1cnccn1>>Cc1cn2ccncc2n1,,CCO,,,,val
US20090247538A1,CC(C)(C)OC(=O)NC1CCN(c2ncnc3c2ncn3C2CCCCO2)CC1.CI>>CN(C(=O)OC(C)(C)C)C1CCN(c2ncnc3c2ncn3C2CCCCO2)CC1,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20150051171A1,COS(=O)(=O)OC.Cc1c(Cl)cccc1-n1nn[nH]c1=O>>Cc1c(Cl)cccc1-n1nnn(C)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20130150340A1,COC(=O)C(C)=O.Nc1cc[nH]n1.O=Cc1ccc(O)cc1>>COC(=O)c1cc(-c2ccc(O)cc2)nc2[nH]ncc12,,CC(=O)O,CO,,,val
US20120110702A1,C=Cc1nn(-c2cncc(F)c2)cc1N(C)C(=O)OC(C)(C)C>>CCc1nn(-c2cncc(F)c2)cc1N(C)C(=O)OC(C)(C)C,[Pd],CO,,N#N,,val
US20030008227A1,CCCCCCCCCCCCCCCCCC[N+](C)(C)Cc1ccccc1.c1ccc([B-](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCCCCCCCCCCCCCCCCC[N+](C)(C)Cc1ccccc1.c1ccc([B-](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,O,,[Cl-].[Na+],,val
US05114936,C1CCNC1.O=C1c2c(-c3ccccc3)noc2CCC1CCCCl>>O=C1c2c(-c3ccccc3)noc2CCC1CCCN1CCCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,[I-].[Na+],val
US06416861B1,C=CCc1cnc(Br)c([SiH](C)C)c1.CN(C)C=O>>C=CCc1cnc(C=O)c([SiH](C)C)c1,,C1CCOC1,,[Li]CCCC,,val
US20080004270A1,CC=O.O=C(Nc1c[nH]nc1-c1nc2c([nH]1)CCNC2)c1c(F)cccc1F>>CCN1CCc2[nH]c(-c3n[nH]cc3NC(=O)c3c(F)cccc3F)nc2C1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20120252758A1,COc1cc(-n2cnc(Cl)c2)cc(C(=O)[O-])n1.Cl>>Cl.O=C(O)c1cc(-n2cnc(Cl)c2)cc(=O)[nH]1,,CC(=O)O,,,,val
US20150087585A1,Nc1nc(N2CCC[C@@H](C(=O)N3CCCC3)C2)ccc1[N+](=O)[O-].O=C(O)C1(n2cc(Cl)cn2)CC1>>O=C([C@@H]1CCCN(c2ccc([N+](=O)[O-])c(NC(=O)C3(n4cc(Cl)cn4)CC3)n2)C1)N1CCCC1,CN(C)c1ccncc1,Cc1ccccc1,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20050267104A1,CCSC(=O)OCI.O=C(O)c1ccccc1>>CCSC(=O)OCOC(=O)c1ccccc1,,ClCCl,,O,,val
US20080207897A1,CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(CBr)c2CC1.OB(O)c1cccnc1>>CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(Cc3cccnc3)c2CC1,,Cc1ccccc1,O,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20040180036A1,CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.O=C(O)/C=C\C(=O)O.O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl>>CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl.O=C([O-])/C=C\C(=O)[O-],,CCOCC,,,,val
US20040009976A1,Cc1ccc(B(O)O)cc1.Clc1ccc2sc(Br)cc2c1>>Cc1ccc(-c2cc3cc(Cl)ccc3s2)cc1,,CCOC(C)=O,,,,val
US05811548,CCCCCCN1c2cccc(CO)c2Sc2c1cccc2C(O[SiH2]C(C)(C)C)(c1ccccc1)c1ccccc1.O=C1NC(=O)c2ccccc21>>CCCCCCN1c2cccc(CN3C(=O)c4ccccc4C3=O)c2Sc2c1cccc2C(O[SiH2]C(C)(C)C)(c1ccccc1)c1ccccc1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150166564A1,CCn1cc(-c2nn(-c3ccccc3)c(NC(=O)Oc3ccccc3)c2C)cn1.COCCN1C[C@@H](c2ccc(F)c(F)c2)[C@H](N)C1>>CCn1cc(-c2nn(-c3ccccc3)c(NC(=O)N[C@@H]3CN(CCOC)C[C@H]3c3ccc(F)c(F)c3)c2C)cn1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05770584,CCCCCCCCCCCCCCCCSCC(CBr)OC.CN(C)CCO>>CCCCCCCCCCCCCCCCSCC(C[N+](C)(C)CCO)OC.[Br-],,CCOCC,,CN(C)C=O,,val
US20060083681A1,COc1nc(Br)c(C)c(O[Si](C)(C)C(C)(C)C)c1OC.O=[N+]([O-])c1ccc(CCBr)cc1>>COc1nc(CCc2ccc([N+](=O)[O-])cc2)c(C)c(O[Si](C)(C)C(C)(C)C)c1OC,,O,,C1CCOC1,[Li]CCCC,val
US20060100245A1,COC(=O)c1ccc(Cl)nc1.OB(O)c1ccccc1Cl>>COC(=O)c1ccc(-c2ccccc2Cl)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20130252944A1,CC(=O)c1[nH]ncc1I.COc1ccc(CCl)cc1>>COc1ccc(Cn2cc(I)c(C(C)=O)n2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US06194461B1,CC(C)(C)N.N#Cc1ccc(C=O)cc1>>CC(C)(C)[N+]([O-])=Cc1ccc(C#N)cc1,,ClCCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US20140349972A1,COC(=O)c1ccc(-c2cc(-c3cnc(-c4ccccn4)nc3OCc3ccc(OC)cc3)on2)cc1>>CCOC(=O)c1ccc(-c2cc(-c3cnc(-c4ccccn4)nc3O)on2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04472404,CCOC(=O)CNC(=O)Oc1ccc(Cl)c2cccnc12.CS(=O)(=O)O>>CCOC(=O)CNC(=O)Oc1ccc(Cl)c2cccnc12.CS(=O)(=O)O,,CC(C)O,,,,val
US20020103230A1,CCOC(=O)Cc1nc2ccccc2[nH]1.N#Cc1ccncc1N>>N#Cc1ccncc1NC(=O)Cc1nc2ccccc2[nH]1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20070185092A1,O=C(NCc1cn(-c2ccc(Br)cn2)cn1)c1ccc(Cl)s1.Oc1ccccn1>>O=C(NCc1cn(-c2ccc(-n3ccccc3=O)cn2)cn1)c1ccc(Cl)s1,[Cu]I,C1COCCO1,CS(C)=O,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US07579417B2,Brc1ccc2ccc(Br)cc2c1.CI>>Cc1ccc2ccc(Br)cc2c1,,CCOCC,,O,[Li]CCCC,val
US20140371199A1,Cc1cc2nccn2cc1Br.II>>Cc1cc2ncc(I)n2cc1Br,,CO,,CC(=O)[O-].[Na+],,val
US20110112297A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.Oc1ccc2c3c1O[C@H]1C(C4OCCO4)CC[C@@]4(O)[C@@H](C2)N(CC2CC2)CC[C@]314>>CC(C)(C)[Si](Oc1ccc2c3c1O[C@H]1C(C4OCCO4)CC[C@@]4(O)[C@@H](C2)N(CC2CC2)CC[C@]314)(c1ccccc1)c1ccccc1,,C1CCOC1,,CCN(CC)CC,O,val
US20100113462A1,CCOC(=O)C1(NC(=O)c2cccc3c2CCCC3)Cc2ccccc2C1>>O=C(NC1(C(=O)O)Cc2ccccc2C1)c1cccc2c1CCCC2,,CCO,,O,[K+].[OH-],val
US20140038975A1,C[C@@](CCn1cc(C2CCCC2)cn1)(C(=O)O)S(C)(=O)=O.NOC1CCCCO1>>C[C@@](CCn1cc(C2CCCC2)cn1)(C(=O)NOC1CCCCO1)S(C)(=O)=O,,O,,CN1CCOCC1,,val
US20080274892A1,Cc1cn(Cc2ccccc2N)c(=O)o1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cn(Cc2ccccc2NS(=O)(=O)C(F)(F)F)c(=O)o1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20070003539A1,CNC(C)(C)C.N#Cc1ccccc1S(=O)(=O)Cl>>CN(C(C)(C)C)S(=O)(=O)c1ccccc1C#N,,C1CCOC1,,CCN(CC)CC,,val
US05344830,CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1.NCCN1CCOCC1>>CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN2CCOCC2)C1,CN(C)c1ccncc1,,,CCN=C=NCCCN(C)C,,val
US05665718,CN1Cc2c(C(N)=NO)ncn2-c2ccc(F)c(Cl)c2C1=O.O=C(CCl)OC(=O)CCl>>CN1Cc2c(-c3noc(CCl)n3)ncn2-c2ccc(F)c(Cl)c2C1=O,,CC#N,CN(C)C=O,C,,val
US20100015178A1,COCCNc1nonc1C(=NO)NCc1cc(Br)co1.O=C(n1ccnc1)n1ccnc1>>COCCNc1nonc1-c1noc(=O)n1Cc1cc(Br)co1,,CCOC(C)=O,,,,val
US20130143862A1,CC(C)(C)OC(=O)N(CC1(c2ncccc2F)CCC1)c1ccc(Cl)nn1.CCOC(C)=O>>C=Cc1ccc(N(CC2(c3ncccc3F)CCC2)C(=O)OC(C)(C)C)nn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20160229814A1,CC(CC(=O)O)CC(=O)Nc1ccc(C#N)c(Cl)c1.CCn1c(=O)c2cc(N)ccc2n(CC#N)c1=O>>CCn1c(=O)c2cc(NC(=O)CC(C)CC(=O)Nc3ccc(C#N)c(Cl)c3)ccc2n(CC#N)c1=O,,CCOC(C)=O,O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20080032968A1,CC(I)c1cccc2c1ccn2S(=O)(=O)c1ccccc1.CN>>CNC(C)c1cccc2c1ccn2S(=O)(=O)c1ccccc1,,CCO,ClCCl,,,val
US06099593,CCOC=CC#N.Cl.Nc1[nH]ncc1[N+](=O)[O-]>>Cl.Nc1ccnc2c([N+](=O)[O-])cnn12,,CC(=O)O,,,,val
US20160159808A1,CCOC(=O)c1c[nH]nc1N.O=C1CCC(=O)N1Br>>CCOC(=O)c1c(N)n[nH]c1Br,,CC#N,,,,val
US20120283271A1,CO.Cc1c(F)cccc1C(=O)O>>COC(=O)c1cccc(F)c1C,,CO,,CCOCC,FB(F)F,val
US20130190290A1,CCOC(CNN)OCC.N#CCC(=O)c1cccnc1>>CCOC(Cn1nc(-c2cccnc2)cc1N)OCC,,CCO,CCOC(C)=O,Cl,,val
US07501407B2,CC#N.O=C(CBr)Nc1cc(Cl)nc(-c2ccccc2)n1.O=[N+]([O-])c1cc(C(F)(F)F)ccc1N1CCNCC1>>O=C(CN1CCCCC1)Nc1cc(Cl)nc(-c2ccccc2)n1,,CC#N,,,,val
US20080015191A1,Clc1cncc(Cl)n1.Oc1ccccc1F>>Fc1ccccc1Oc1cncc(Cl)n1,,C1CCCCC1,,CCOC(C)=O,,val
US20080171737A1,ClCCCBr.O=S1(=O)CCc2ccccc2N1c1ccccc1F>>O=S1(=O)C(CCCCl)Cc2ccccc2N1c1ccccc1F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120245144A1,Cc1nc(-c2cn3c(n2)-c2ccc(S(=O)C4CCN(C(C)C)CC4)cc2OCC3)n(C(C)C)n1.O=C(OO)c1cccc(Cl)c1>>Cc1nc(-c2cn3c(n2)-c2ccc(S(=O)(=O)C4CCN(C(C)C)CC4)cc2OCC3)n(C(C)C)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130281392A1,FC(F)(F)c1nc2cc(Cl)c(I)cc2[nH]1.OB(O)c1ccc(Cl)cc1>>FC(F)(F)c1nc2cc(Cl)c(-c3ccc(Cl)cc3)cc2[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20090270435A1,O=C(O)c1ccc2[nH]ccc2c1.O=C1CCC(=O)N1Cl>>O=C(O)c1ccc2c(Cl)c[nH]c2c1,,CN(C)C=O,,ClCCl,,val
US20110230428A1,COC(=O)CCC(=NOCCN(C)C)c1ccc(Cl)c(Cl)c1>>CN(C)CCON=C(CCC(=O)O)c1ccc(Cl)c(Cl)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20150344429A1,CC(N)(C#N)CC1CC1.O=C(Cl)OCc1ccccc1>>CC(C#N)(CC1CC1)NC(=O)OCc1ccccc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20150152102A1,CC(C)Oc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nn1.Cl>>CC(C)Oc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nn1.Cl,,CCO,,,,val
US06143779,CCC(=O)Cl.COc1ccc(C=C2Oc3cc(O)ccc3C2=O)cc1OC>>CCC(=O)Oc1ccc2c(c1)OC(=Cc1ccc(OC)c(OC)c1)C2=O,,c1ccncc1,,CCOC(C)=O,,val
US20080312226A1,CC(C)(C)OC(=O)N1CCNCC1.Fc1ccccc1-c1nsc(Cl)n1>>CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccccc3F)ns2)CC1,,CN(C)C=O,,CCN(CC)CC,O,val
US20130137680A1,CCOC(=O)c1ccc2cc(C(=O)OCC)n(C(C)C#N)c2n1>>CCOC(=O)c1ccc2cc3n(c2n1)C(C)CNC3=O,,C1CCOC1,CO,[BH4-].[Na+],,val
US20140221374A1,CC1(C)OB(c2cccc(N)c2)OC1(C)C.O=C=Nc1ccc(C(F)(F)F)cc1>>CC1(C)OB(c2cccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c2)OC1(C)C,,C1CCOC1,,,,val
US20070043044A1,COC(=O)c1cc2c(Cl)nc(N)nc2s1.NCc1ccccc1>>COC(=O)c1cc2c(NCc3ccccc3)nc(N)nc2s1,,C1CCOC1,,,,val
US20030186985A1,Cc1oc(-c2ccccc2)nc1COc1ccc(CON)cc1.O=C1CC(C(=O)O)c2ccccc21>>Cc1oc(-c2ccccc2)nc1COc1ccc(CO/N=C2\CC(C(=O)O)c3ccccc32)cc1,,CCO,O,CC(=O)O,CC(=O)[O-].[Na+],val
US20150133512A1,COC(=O)c1cnnn1-c1ccc(Br)cc1>>O=C(O)c1cnnn1-c1ccc(Br)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20090092550A1,COC(=O)CCC1=C(C)C2=NC1(CCC(=O)OC)C(C)=C1NC(C)(C=C3C=CC(=N3)C=c3ccc([nH]3)=C2)C=C1C.COC(=O)CCC1=C(C)c2cc3cc(C)c(cc4cc(C)c(cc5nc(cc1n2)C(CCC(=O)OC)=C5C)[nH]4)[nH]3>>CC1=C(CCC(=O)O)c2cc3nc(cc4[nH]c(cc4C)cc4[nH]c(cc1n2)cc4C)C(C)=C3CCC(=O)O.CC1=CC2(C)C=C3C=CC(=N3)C=c3ccc([nH]3)=CC3=NC(CCC(=O)O)(C(C)=C1N2)C(CCC(=O)O)=C3C,,CO,O,[K+].[OH-],,val
US20150291577A1,CC(C)(C)OC(=O)N(CC1CC1)[C@@H]1C[C@H]1c1ccc(C(=O)NC2CCC(F)(F)CC2)s1.Cl>>Cl.O=C(NC1CCC(F)(F)CC1)c1ccc([C@@H]2C[C@H]2NCC2CC2)s1,,CCOC(C)=O,,,,val
US04997942,COc1ccc(Br)cc1F.N#C[Cu]C#N>>COc1ccc(C#N)cc1F,,CN(C)C=O,O,,,val
US20140045828A1,O=C1N[C@@]2(CO1)c1cc(Br)ccc1Oc1ccc(I)cc12>>N[C@@]1(CO)c2cc(Br)ccc2Oc2ccc(I)cc21,,C1COCCO1,CO,[K+].[OH-],,val
US20110190489A1,C=CCc1cnc2[nH]ccc2c1Cl.Cc1ccc(S(=O)(=O)Cl)cc1>>C=CCc1cnc2c(ccn2S(=O)(=O)c2ccc(C)cc2)c1Cl,,CN(C)C=O,,[H-].[Na+],,val
US05834482,ClCCCBr.c1ccc(-c2noc(-c3cc4c(cn3)[nH]c3ccccc34)n2)cc1>>ClCCCn1c2ccccc2c2cc(-c3nc(-c4ccccc4)no3)ncc21,,CN(C)C=O,,[H-].[Na+],,val
US20050261350A1,CCN1C(=O)C(C)(C)c2cc(NC(=O)c3ccnc(Cl)c3)c([N+](=O)[O-])cc21>>CCN1C(=O)C(C)(C)c2cc3[nH]c(-c4ccnc(Cl)c4)nc3cc21,[Ni],,,,,val
US20030166637A1,C=CCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc21.OO>>O=C(NCC(F)(F)F)C1(CCCO)c2ccccc2-c2ccccc21,,C1CCOC1,O,B1C2CCCC1CCC2,[Na+].[OH-],val
US20120101086A1,Cc1c2c(nn1-c1nnc(-c3ccc(OC(C)C)c(C#N)c3)s1)CCN(CCC(=O)OC(C)(C)C)C2.O=C(O)C(F)(F)F>>Cc1c2c(nn1-c1nnc(-c3ccc(OC(C)C)c(C#N)c3)s1)CCN(CCC(=O)O)C2.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20110098221A1,CCOC(=O)c1ncc(-c2ccnn2C)s1>>Cn1nccc1-c1cnc(C(=O)O)s1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20150166564A1,COCCN1C[C@@H](N)[C@H](c2ccc(F)c(F)c2)C1.Nc1c(Cl)c(-c2ccccn2)nn1-c1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COCCN1C[C@@H](NC(=O)Nc2c(Cl)c(-c3ccccn3)nn2-c2ccccc2)[C@H](c2ccc(F)c(F)c2)C1,,ClCCl,,CCN(C(C)C)C(C)C,[Na+].[OH-],val
US20150119435A1,CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1CCCC(=O)O.NCCOCCNC(=O)CC12CC3CC(CC(C3)C1)C2>>CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1CCCC(=O)NCCOCCNC(=O)CC12CC3CC(CC(C3)C1)C2,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US20040162303A1,C1=CCNCC1.CS(=O)(=O)Cl>>CS(=O)(=O)N1CC=CCC1,,ClCCl,,CCN(CC)CC,,val
US20120270865A2,CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(O)cc3c2C)C2CCCCC2)cc1.OCc1ccnc(F)c1>>CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(OCc4ccnc(F)c4)cc3c2C)C2CCCCC2)cc1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20080004321A1,CC1(C)OC(=O)CC(=O)O1.CCCc1c(OCc2cccc(NC(=O)c3cccc(C(=O)O)c3)c2)ccc(C(C)=O)c1O>>CCCc1c(OCc2cccc(NC(=O)c3cccc(C(O)=C4C(=O)OC(C)(C)OC4=O)c3)c2)ccc(C(C)=O)c1O,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05254685,CCOC(=O)c1cn2c3c(c(F)c(F)cc3c1=O)CCN2.COS(=O)(=O)OC>>COC(=O)c1cn2c3c(c(F)c(F)cc3c1=O)CCN2C,,O,,O=C([O-])[O-].[K+].[K+],,val
US05688798,Cc1ncc(CCl)c(N)n1.c1ccc(-c2ccc3c(c2)CCNC3)cc1>>Cc1ncc(CN2CCc3cc(-c4ccccc4)ccc3C2)c(N)n1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US04473570,N.O=c1cc(CCl)[nH]c(=O)[nH]1>>NCc1cc(=O)[nH]c(=O)[nH]1,,CCOC(C)=O,,,,val
US20050131056A1,CCOC(=O)c1sc(C(=O)O)c2c1-c1ccccc1Oc1ccccc1-2>>CCOC(=O)c1scc2c1-c1ccccc1Oc1ccccc1-2,[Cu],CCOCC,,,,val
US20090176770A1,CN1CCN(C2CCNCC2)CC1.O=C(O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)OC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1>>CN1CCN(C2CCN(C(=O)[C@@H](Cc3cc(Br)c(O)c(Br)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120122842A1,CCCNC(=O)c1ccc(NC(=O)N2Cc3ccc(N)cc3C2)cc1.CS(=O)(=O)Cl>>CCCNC(=O)c1ccc(NC(=O)N2Cc3ccc(NS(C)(=O)=O)cc3C2)cc1,,CN(C)C=O,,c1ccncc1,,val
US20110263626A1,O=Cc1ccc(F)cc1F.Oc1ccccc1Cl>>O=Cc1ccc(Oc2ccccc2Cl)cc1F,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130237555A1,CC(=O)Nc1cc(-c2ccc(Cl)cc2F)c(CO)cn1>>CC(=O)Nc1cc2c(cn1)COc1cc(Cl)ccc1-2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120122860A1,COC(=O)/C=C/c1cnc2[nH]ccc2c1>>COC(=O)CCc1cnc2[nH]ccc2c1,,C1CCOC1,CO,,,val
US05025031,O=C=NS(=O)(=O)Cl.O=[N+]([O-])c1cccc(O)c1>>NS(=O)(=O)Oc1cccc([N+](=O)[O-])c1,,Cc1ccccc1,,,,val
US20140371068A1,C=CCBr.Cc1nonc1NC(=O)c1ccc(C(F)(F)F)c(S(C)(=O)=O)c1C>>C=CCN(C(=O)c1ccc(C(F)(F)F)c(S(C)(=O)=O)c1C)c1nonc1C,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20080039459A1,C[C@H](O)CSc1cccc(-c2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)c1.O=S([O-])OO>>C[C@H](O)CS(=O)(=O)c1cccc(-c2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)c1,,CO,,O,,val
US20070248672A1,CN.COc1ccc(-c2c(C=O)[nH]c3cc(OC)c(OC)cc23)cc1.Cl>>CNCc1[nH]c2cc(OC)c(OC)cc2c1-c1ccc(OC)cc1.Cl,,CO,ClCCl,[BH3-]C#N.[Na+],,val
US20070099877A1,CCOC(=O)C=Cc1ccc(N)cc1.Clc1ncnc2ccsc12>>CCOC(=O)C=Cc1ccc(Nc2ncnc3ccsc23)cc1,Cl,CC(C)O,,,,val
US20090192162A1,CCOC(=O)COc1ccc(Sc2cc(C#Cc3ccc(Cl)cc3)cc(OCC3CCN(C)CC3)c2)cc1Cl>>CN1CCC(COc2cc(C#Cc3ccc(Cl)cc3)cc(Sc3ccc(OCC(=O)O)c(Cl)c3)c2)CC1,,CCO,,Cl,[Na+].[OH-],val
US20110294776A1,O=C(C1CC1)N1CCN(Cc2ccccc2)CC1>>O=C(C1CC1)N1CCNCC1,[Pd],CCO,,,,val
US20130295141A1,CC1(C)O[C@@H]2O[C@H](/C=C/c3ccc(Br)cc3)[C@H](CCN3C(=O)c4ccccc4C3=O)[C@@H]2O1.OB(O)c1cc(F)cc(F)c1>>CC1(C)O[C@@H]2O[C@H](/C=C/c3ccc(-c4cc(F)cc(F)c4)cc3)[C@H](CCN3C(=O)c4ccccc4C3=O)[C@@H]2O1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US04165377,CSC(=N)N[N+](=O)[O-].N=C(N)Nc1nc(CCCCN)cs1>>N=C(N)Nc1nc(CCCCNC(N)=N[N+](=O)[O-])cs1,,CCO,,,,val
US03931407,Nc1cccc(C(=O)O)c1.O=C(CC1CCc2ccccc2C1=O)c1ccccc1>>O=C(O)c1cccc(-n2c(-c3ccccc3)cc3c2-c2ccccc2CC3)c1,,CC(=O)O,,,,val
US20080045521A1,CN(C(=O)OC(C)(C)C)c1cccc(CCOc2ccc(C[C@H](N)C(=O)OC(C)(C)C)cn2)n1.O=C(Cl)c1c(Cl)cccc1Cl>>CN(C(=O)OC(C)(C)C)c1cccc(CCOc2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)OC(C)(C)C)cn2)n1,,ClCCl,,,,val
US20140057299A1,Nc1ccc(N2CCNCC2)c(Cl)c1Cl.O=C1CCc2ccc(OCCCCBr)cc2N1>>Nc1ccc(N2CCN(CCCCOc3ccc4c(c3)NC(=O)CC4)CC2)c(Cl)c1Cl,,CN(C)C=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US05468877,COC(=O)c1cc(SC(F)(F)F)c(-c2ccc(Cl)cc2)[nH]1>>O=C(O)c1cc(SC(F)(F)F)c(-c2ccc(Cl)cc2)[nH]1,,CO,O,[Na+].[OH-],,val
US20120053166A1,CC1(C)CNCCO1.O=S(=O)(c1ccccc1)n1ncc2c(-c3nnc(CCl)o3)cc(Br)cc21>>CC1(C)CN(Cc2nnc(-c3cc(Br)cc4c3cnn4S(=O)(=O)c3ccccc3)o2)CCO1,,CC#N,ClCCl,CCN(C(C)C)C(C)C,[I-].[Na+],val
US20130096113A1,CSc1nc2ccc(Cn3cnc4cncnc43)cc2o1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc2ccc(Cn3cnc4cncnc43)cc2o1,,ClCCl,,,,val
US20040186077A1,Cc1cnc(C)c(OCc2ccccc2)c1C(O)P(=O)(OC(C)(C)C)OC(C)(C)C>>Cc1cnc(C)c(OCc2ccccc2)c1C(O)P(=O)(O)O,,CC(=O)O,O,,,val
US05162534,CI.COC(CN)OC.S=C=S>>COC(CNC(=S)SC)OC,,CCO,O,CCN(CC)CC,,val
US20090098218A1,CCOC(=O)C1(C(N)=O)CN(C(=O)OC(C)(C)C)C1>>CCOC(=O)C1(C#N)CN(C(=O)OC(C)(C)C)C1,,C1CCOC1,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,c1ccncc1,val
US20110257151A1,COC(=O)c1ccc2c(c1)CC(C)(C)C(c1cccc(C(=O)O)c1)N2.NS(=O)(=O)C1CC1>>COC(=O)c1ccc2c(c1)CC(C)(C)C(c1cccc(C(=O)NS(=O)(=O)C3CC3)c1)N2,,C1CCOC1,CCOC(C)=O,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20050222139A1,CCOC(=O)c1csc(CN(C)S(=O)(=O)c2ccc(Br)cc2)n1>>CN(Cc1nc(C(=O)O)cs1)S(=O)(=O)c1ccc(Br)cc1,,C1COCCO1,,[Li+].[OH-],,val
US20100197675A1,CC(O)CCNC(=O)C12CC3CC(CC(C3)C1)C2>>CC(O)CCNCC12CC3CC(CC(C3)C1)C2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040259876A1,CCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCCN3CC(C)C)cc1>>CCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCCN3CC(C)C)cc1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US04897425,Cc1ccncc1.O=[N+]([O-])c1ccc(CCl)cc1>>Cc1cc[n+](Cc2ccc([N+](=O)[O-])cc2)cc1.[Cl-],,CC#N,,,,val
US05530009,CC(=O)OC(C)=O.COc1ccccc1CNC[C@@H](Cc1c[nH]c2ccccc12)NC(c1ccccc1)(c1ccccc1)c1ccccc1>>COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(C)=O,,C1CCOC1,,CCN(CC)CC,,val
US20030225131A1,C[Si](C)(C)CCOCCl.O=[N+]([O-])c1c(O)ccnc1Cl>>C[Si](C)(C)CCOCn1ccc(=O)c([N+](=O)[O-])c1Cl,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20090047246A1,BrCc1nc2ccccc2s1.CCOC(=O)Cc1c[nH]c2cc(Br)ccc12>>CCOC(=O)Cc1cn(Cc2nc3ccccc3s2)c2cc(Br)ccc12,,CN(C)C=O,,[H-].[Na+],,val
US20130210795A1,BrP(Br)Br.COC(=O)c1cccc(C(C)O)c1>>COC(=O)c1cccc(C(C)Br)c1,,Cc1ccccc1,,,,val
US20030225125A1,Nc1cccc(CCC(=O)O)c1.O=C=Nc1cccc(Cl)c1Cl>>O=C(O)CCc1cccc(NC(=O)Nc2cccc(Cl)c2Cl)c1,,CN(C)C=O,,,,val
US20070129345A1,O=C(OCc1ccccc1)N1CCC2(CC1)CCN(C1CCCCC1)C2=O>>O=C1N(C2CCCCC2)CCC12CCNCC2,[Pd],CO,,,,val
US20110071150A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccc(C(N)=O)cc1Br>>Cc1ccc(C(N)=S)cc1Br,,ClCCl,,,,val
US20070027148A1,O=C1COc2c(cc(OCc3ccccc3)cc2C(=O)CCl)N1>>O=C1COc2c(cc(OCc3ccccc3)cc2[C@@H](O)CCl)N1,,CN(C)C=O,,CCN(CC)CC,O=CO,val
US20090036450A1,CC(=O)CC(=O)OCCCl.NC(=O)CCc1ccccc1>>CCOC(=O)c1oc(CCc2ccccc2)nc1C,,O,,,,val
US20070155803A1,CC(C)(C)OC(=O)NN1CC[C@@H](NC(=O)OCc2ccccc2)C1=O>>NN1CC[C@@H](NC(=O)OCc2ccccc2)C1=O,,ClCCl,,O,O=C(O)C(F)(F)F,val
US20040024201A1,COC(=O)CCCCCO[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1N1C(=O)c2ccccc2C1=O>>COC(=O)CCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1N1C(=O)c2ccccc2C1=O,,CO,,C[O-].[Na+],,val
US20150299188A1,N#Cc1c(Cl)cncc1Cl.[N-]=[N+]=[N-]>>N#Cc1c(Cl)cncc1N=[N+]=[N-],,CN(C)C=O,,O,,val
US20120122942A1,CCCCCCc1cc2ccccc2n1C(=O)CC(C)CC(=O)OC>>CCCCCCc1cc2ccccc2n1C(=O)C[C@@H](C)CC(=O)O,,CCCCCC,,CCOC(C)=O,[Cl-].[NH4+],val
US20110015157A1,COC(=O)c1ccc(Br)cn1.C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O>>C[C@@H](c1ccc(-c2ccc(C(=O)O)nc2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O,,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20060128766A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.[N-]=[N+]=[N-]>>[N-]=[N+]=NS(=O)(=O)C(F)(F)F,,ClCCl,,O,,val
US20150119385A1,COC(OC)c1nc2c(cc1N1CCOC1=O)CCCN2.COCCNc1cc(N)ncc1C#N.O=C(n1cncn1)n1cncn1>>COCCNc1cc(NC(=O)N2CCCc3cc(N4CCOC4=O)c(C(OC)OC)nc32)ncc1C#N,,CN(C)C=O,,,,val
US04362728,CN.CSC(=NC#N)NCCSCc1nsc(NC(N)=NCC(F)(F)F)n1>>CNC(=NC#N)NCCSCc1nsc(NC(N)=NCC(F)(F)F)n1,,CCO,,,,val
US20080119555A1,Fc1ccc(-c2ccccc2)cc1.O=S(=O)(O)Cl>>O=S(=O)(O)c1ccccc1-c1ccc(F)cc1,,ClC(Cl)Cl,,,,val
US20100330199A1,CCCCOC(=O)c1nc(Br)c2c(C)nsc2c1O>>CCCCOC(=O)c1ncc2c(C)nsc2c1O,[Pd],CCO,CCOC(C)=O,O=C[O-].[NH4+],,val
US20060264429A1,COC(=O)CBr.O=[N+]([O-])c1cccc(F)c1O>>COC(=O)COc1c(F)cccc1[N+](=O)[O-],,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150038738A1,CC(=O)N(C)C.O=C1CCC(=O)O1.c1ccncc1>>CCC1=C[C@H]2C(=O)C[C@H]2C1,CN(C)c1ccncc1,CC(=O)N(C)C,,,,val
US20080207684A1,C1CCOC1.CC(=O)O.CCC=O.CNC(=O)c1ccc(C)c(C2=CC3NN=C(N)C3N(C)C2=O)c1>>CCCN(CCC)C1=NNC2C=C(c3cc(C(=O)NC)ccc3C)C(=O)N(C)C12,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140057920A1,CC(C)(C)OC(=O)NCc1ccc2sccc2c1.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)NCc1ccc2c(c1)C=CS2(=O)=O,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20130059853A1,CC(C)CBr.COc1ccc(-c2ccc3c(c2)COC3=O)c(OC)c1O>>COc1ccc(-c2ccc3c(c2)COC3=O)c(OC)c1OCC(C)C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20120142685A1,CC(C)(C)OC(=O)N1CCNCC1.Clc1cc(-c2cc3cnccc3c(Cl)n2)ccn1>>CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccnc(Cl)c3)cc3cnccc23)CC1,,CCO,CCOCC,CCN(CC)CC,,val
US20150183781A1,Cn1cc(-c2cnc3[nH]ccc3c2)cn1.O=C1CCC(=O)N1I>>Cn1cc(-c2cnc3[nH]cc(I)c3c2)cn1,,CC(C)=O,,,,val
US05621104,CC12CCC(=O)C=C1CCc1ccccc12.OCCO>>CC12CC3OCCOC3CC1=CCc1ccccc12,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20140275016A1,CC(C)(C)C(N)=O.Cc1nc(N)ccc1Oc1ccnc(NC(=O)N2CCCC2)c1.O=C(Cl)C(=O)Cl>>Cc1nc(NC(=O)NC(=O)C(C)(C)C)ccc1Oc1ccnc(NC(=O)N2CCCC2)c1,,C1CCOC1,ClCCCl,c1ccncc1,,val
US05411980,CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1.O=C(Cl)c1ccccc1>>CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1,,c1ccncc1,,,,val
US20140221333A1,COc1ccc(CNc2nccn3c([C@@H]4CCCN(C(=O)OCc5ccccc5)C4)nc(-c4ccc(C(N)=O)cc4F)c23)c(OC)c1>>COc1ccc(CNc2nccn3c([C@@H]4CCCNC4)nc(-c4ccc(C(N)=O)cc4F)c23)c(OC)c1,,Br,CC(=O)O,COC(C)(C)C,,val
US20040106645A1,NC1CCN(CC=Cc2ccccc2)CC1.O=c1cc(OS(=O)(=O)C(F)(F)F)c2cc(Br)ccc2o1>>O=c1cc(NC2CCN(CC=Cc3ccccc3)CC2)c2cc(Br)ccc2o1,,CC#N,,CCN(CC)CC,,val
US20020016347A1,Brc1cnc2ccccc2c1.Cc1ccccc1C(=O)c1ccc(N)cc1Cl>>Cc1ccccc1C(=O)c1ccc(Nc2cnc3ccccc3c2)cc1Cl,,C1COCCO1,,CC(C)(C)O[Na],,val
US20050153959A1,Cc1cc(CC(NC(=O)OC(C)(C)C)c2ncc[nH]2)cc2cn(COCC[Si](C)(C)C)nc12.Fc1ccc(CBr)cc1>>Cc1cc(CC(NC(=O)OC(C)(C)C)c2nccn2Cc2ccc(F)cc2)cc2cn(COCC[Si](C)(C)C)nc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050101587A9,CC(C)(C)OC(=O)N1CCC(O)CC1.Clc1noc2ccccc12>>CC(C)(C)OC(=O)N1CCC(Oc2noc3ccccc23)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20130184459A1,N#Cc1cccc(C(O)c2ccc3ccccc3c2[N+](=O)[O-])c1>>N#Cc1cccc(C(=O)c2ccc3ccccc3c2[N+](=O)[O-])c1,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US04656299,COC(=O)C1([Na])C=CC=C1.COC(=O)Cl>>COC(=O)C1=CC=CC1([Na])C(=O)OC,,C1CCOC1,,,,val
US20050090508A1,CN(C)CCCO.C[C@H](Nc1c(-c2c(F)cc(F)cc2F)c(Br)nc2ncnn12)C(F)(F)F>>C[C@H](Nc1c(-c2c(F)cc(OCCCN(C)C)cc2F)c(Br)nc2ncnn12)C(F)(F)F,,CS(C)=O,,O,[H-].[Na+],val
US20150210630A1,CCON.O=C(CN1C(=O)c2ccccc2C1=O)c1ncc(C(F)(F)F)cc1Cl>>CCON=C(CN1C(=O)c2ccccc2C1=O)c1ncc(C(F)(F)F)cc1Cl,,CCO,,Cl,O,val
US20130131135A1,CCOC(=O)c1cc(C)n(Cc2cc(Cl)ccc2O)n1.Clc1ccc(CBr)cc1>>CCOC(=O)c1cc(C)n(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2)n1,,CN(C)C=O,O,[I-].[K+],,val
US20160251339A1,COc1c(N2CCN(C(=O)C(Cl)(Cl)Cl)CC2)cc(S(=O)(=O)Cl)c2ccccc12.Cc1c[nH]c2cc(Cl)ccc12>>COc1c(N2CCN(C(=O)C(Cl)(Cl)Cl)CC2)cc(S(=O)(=O)n2cc(C)c3ccc(Cl)cc32)c2ccccc12,,C1CCOC1,,[H-].[Na+],,val
US20090253709A1,CCCN.O=C(CCCl)Nc1ccc2c(c1)C(=O)c1cc(NC(=O)CCCl)ccc1C2=O.c1ccncc1>>CCCNCCC(=O)Nc1ccc2c(c1)C(=O)c1cc(NC(=O)CCNCCC)ccc1C2=O,,CN(C)C=O,,,,val
US20140296245A1,COc1ccc(CNc2nc(C)ns2)c(OC)c1.O=S(=O)(Cl)c1cc(F)c(F)cc1F>>COc1ccc(CN(c2nc(C)ns2)S(=O)(=O)c2cc(F)c(F)cc2F)c(OC)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20130252960A1,COC(=O)c1ccc(Cl)nc1.Oc1ccc(C(F)(F)F)cc1>>COC(=O)c1ccc(Oc2ccc(C(F)(F)F)cc2)nc1,,CCOCC,CS(C)=O,[H-].[Na+],,val
US20110150864A1,CC(C)(C)OC(=O)NCC(=O)O.O=C1N=C(N2CCCNCC2)SC1=Cc1ccc2c(cnn2Cc2ccc(Cl)cc2C(F)(F)F)c1>>NCC(=O)N1CCCN(C2=NC(=O)C(=Cc3ccc4c(cnn4Cc4ccc(Cl)cc4C(F)(F)F)c3)S2)CC1,,ClCCl,,CCN(CC)CC,CCN=C=NCCCN(C)C,val
US05532243,CC(C)(C)[Si](C)(C)Oc1ccc(C2(O)CC[C@H]3CN(C(=O)c4ccccc4)CC[C@@H]3C2)cc1>>Oc1ccc(C2(O)CC[C@H]3CN(Cc4ccccc4)CC[C@@H]3C2)cc1,,C1CCOC1,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20060217372A1,NC(=O)c1ccc(Oc2ccc(C=O)cc2)nc1.c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>NC(=O)c1ccc(Oc2ccc(CN3CCN(C(c4ccccc4)c4ccccc4)CC3)cc2)nc1,,CO,,[BH4-].[Na+],,val
US20140275024A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@H](N)CC1.Clc1ncccn1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](Nc2ncccn2)CC1,,CCOC(C)=O,CN(C)C=O,,,val
US08859555B2,CN1CCNCC1.ClCCN[C@@H]1C[C@H]1c1ccccc1>>CN1CCN(CCN[C@@H]2C[C@H]2c2ccccc2)CC1.Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20010039348A1,N#CCBr.Oc1cc(C(F)(F)F)ccc1F>>N#CCOc1cc(C(F)(F)F)ccc1F,,O,,CC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20150126498A1,COc1ccc(NS(=O)(=O)c2ccccc2N)cn1.O=C(n1ccnc1)n1ccnc1>>COc1ccc(N2C(=O)Nc3ccccc3S2(=O)=O)cn1,,CN(C)C=O,,CCN(CC)CC,,val
US20150238601A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Clc1nccc(Oc2ccc3[nH]ncc3c2)n1>>CC(C)(C)OC(=O)n1ncc2cc(Oc3ccnc(Cl)n3)ccc21,CN(C)c1ccncc1,ClCCl,,,,val
US20110201605A1,Cc1cc(N2CCC(=O)CC2)ncn1.Nc1nc2c(N3CCOCC3)cccn2n1>>Cc1cc(N2CCC(Nc3nc4c(N5CCOCC5)cccn4n3)CC2)ncn1,,CO,ClCCl,,,val
US20130064770A1,NCCCCN1CCN(c2cccc(F)n2)CC1.O=C(Cl)C1CCCCC1>>O=C(NCCCCN1CCN(c2cccc(F)n2)CC1)C1CCCCC1,,ClCCl,,CCN(CC)CC,,val
US05298625,CCOC(=O)CC(=O)CP(=O)(OCC)OCC>>CCOC(=O)CC(O)CP(=O)(OCC)OCC,O=[Pt]=O,CO,,,,val
US20070093488A1,CC(=O)Nc1nc2ccc(OS(=O)(=O)c3ccc(F)cc3)cc2s1.CC(C)NCCN>>CC(=O)Nc1nc2ccc(OS(=O)(=O)c3ccc(NCCNC(C)C)cc3)cc2s1,,CS(C)=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05779936,CCCC1CCC(C2CCC(OCCCO)CC2)CC1.CCN(CC)S(F)(F)F>>CCCC1CCC(C2CCC(OCCCF)CC2)CC1,,Cc1ccccc1,,ClCCl,,val
US20060247283A1,COC(C)(C)OC.Oc1cccc(O)c1O>>CC1(C)Oc2cccc(O)c2O1,,Cc1ccccc1,,,,val
US20120220588A1,CNS(=O)(=O)c1ccc(F)c([N+](=O)[O-])c1.O=C(Cl)OCc1ccccc1>>O=C(NCS(=O)(=O)c1ccc(F)c([N+](=O)[O-])c1)OCc1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US20100298221A1,O=Cc1ccc(-c2ccc(Cl)nc2)nc1Cl.Oc1ccccc1Cl>>O=Cc1ccc(-c2ccc(Cl)nc2)nc1Oc1ccccc1Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100216746A1,CC(C)(C)OCCC(=O)Nc1ccc2cc(C(=O)O)n(C(=O)OC(C)(C)C)c2c1.N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CN)c2F)c1>>CC(C)(C)OCCC(=O)Nc1ccc2cc(C(=O)NCc3ccc(Cl)c(Oc4cc(Cl)cc(C#N)c4)c3F)[nH]c2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110207935A1,COCOc1cc(B2OC(C)(C)C(C)(C)O2)ccc1C(=O)OC.N#Cc1cc(Cl)nc2ccccc12>>COC(=O)c1ccc(-c2cc(C#N)c3ccccc3n2)cc1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US05234818,NN.c1ccc(-c2cc3ccc4ccccc4n3n2)cc1>>Nc1c(-c2ccccc2)nn2c1ccc1ccccc12,[Pd],CCO,,O,,val
US06548494B1,CN(C)/C=C/C(=O)c1c(-c2ccc(F)cc2)cc2c3c1ccn3C(=O)CNC2.NN>>O=C1CNCc2cc(-c3ccc(F)cc3)c(-c3ccn[nH]3)c3ccn1c23,,C1CCOC1,,O,,val
US20130102776A1,CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2OCC3=O)CC1.O=Cc1cn(S(=O)(=O)c2c(Cl)cccc2Cl)c2ccccc12>>CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2O/C(=C\c2cn(S(=O)(=O)c4c(Cl)cccc4Cl)c4ccccc24)C3=O)CC1,,CO,,C1CCNCC1,,val
US04918081,CCOC(=O)CCC(Oc1ccccc1C)C(=O)OCC.O=C1CCC(=O)N1Br>>CCOC(=O)CCC(Oc1ccccc1CBr)C(=O)OCC,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20050054683A1,CC(=O)NC[C@H]1CN(c2ccc(C3CCNCC3)c(F)c2)C(=O)O1.CS(=O)(=O)Cl>>CC(=O)NC[C@H]1CN(c2ccc(C3CCN(S(C)(=O)=O)CC3)c(F)c2)C(=O)O1,,ClCCl,,c1ccncc1,,val
US05516774,Cc1ccccc1C(=O)Nc1ccc(C(=O)Cl)cc1.c1ccc2c(c1)NCCc1cccn1-2>>Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3cccn3-c3ccccc32)cc1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US05591762,CCCCc1nc2c(C)ccc(OCCCCCn3cnc4ccccc43)c2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1>>CCCCc1nc2c(C)ccc(OCCCCCn3cnc4ccccc43)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130109708A1,CC(C)O.O=C(O)c1cc(F)c(OCc2cnc(Cl)c(Cl)c2)cc1F>>CC(C)Oc1ncc(COc2cc(F)c(C(=O)O)cc2F)cc1Cl,,C1CCOC1,,Cl,[H-].[Na+],val
US05817780,O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>O=C(O)[C@@H](O)[C@H](O)[C@H](O)CO,,CO,,O=O,,val
US20070049618A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O>>CC(C)(C)OC(=O)NCc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,,C1CCOC1,,CCN(CC)CC,Cl,val
US04588719,CI.COc1ccc2c(c1)C(C#N)C2>>COc1ccc2c(c1)C(C)(C#N)C2,,C1CCOC1,CCOCC,O,[H-].[Na+],val
US20160184265A1,CC(C)Br.[C-]#[N+]CS(=O)(=O)c1ccccc1C>>[C-]#[N+]C(C(C)C)S(=O)(=O)c1ccc(C)cc1,,CCOCC,,CS(C)=O,[H-].[Na+],val
US20100056478A1,Nc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)cc1.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O>>O=C(Nc1ccc(NC(=O)ON2C(=O)CCC2=O)cc1)OCC1c2ccccc2-c2ccccc21,,CC#N,,,,val
US05530150,O=S(=O)(Oc1ccc2ccccc2c1-c1c(OS(=O)(=O)C(F)(F)F)ccc2ccccc12)C(F)(F)F.O=[PH3]>>O=[PH2]c1ccc2ccccc2c1-c1c(OS(=O)(=O)C(F)(F)F)ccc2ccccc12,[Pd],,,,,val
US04096336,COC(=O)CCCc1ccccc1CC1C(=O)CC(=O)C1=O>>COC(=O)CCCc1ccccc1CC1C(=O)CC(O)C1=O,[Pd],CC(C)O,,Cc1ccccc1,,val
US20130064770A1,BrCCOCc1ccccc1.CC(=O)n1ncc(=O)[nH]c1=O>>O=c1cn[nH]c(=O)n1CCOCc1ccccc1,,CN(C)C=O,O,[H-].[Na+],,val
US05210092,CCCCc1nc2c(C)ccnc2[nH]1.N#Cc1c(Cl)c(Cl)cn1-c1ccc(CBr)cc1>>CCCCc1nc2c(C)ccnc2n1Cc1ccc(-n2cc(Cl)c(Cl)c2C#N)cc1,,CS(C)=O,,[H-].[Na+],,val
US20150272934A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCCCl>>CC(C)(C)OC(=O)NCCCCl,,ClCCl,,CCN(CC)CC,Cl,val
US20150299354A1,C=C.FC(F)(I)C(F)(F)C(F)(F)I>>C=CC(F)(F)C(F)(F)C(F)(F)I,,CO,,C[O-].[Na+],,val
US20110144110A1,CCOC(=O)CCc1ccc(-c2ccc(N)cc2)n1-c1ccc(C(N)=O)cc1C>>Cc1cc(C(N)=O)ccc1-n1c(CCC(=O)O)ccc1-c1ccc(N)cc1,,CO,,[Na+].[OH-],,val
US20120295924A1,CCN=C=NCCCN(C)C.Cc1scc2c1c(=O)n(C)c(=O)n2C.Nc1nc(-c2ccc(F)c(C(F)(F)F)c2F)cs1.On1nnc2ccccc21>>Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(C(F)(F)F)c4F)cs3)csc2n(C)c1=O,CN(C)c1ccncc1,ClCCCl,,Cl,,val
US20080262042A1,C=C1CN(C(=O)OC(C)(C)C)C(O)(c2cccnc2F)C1(F)F>>C=C1CN=C(c2cccnc2F)C1(F)F,,CC(=O)O,,Cl,,val
US20130065880A1,COC(=O)CBr.Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)NCCCN)c[nH]4)c3)cc2)c1>>COC(=O)CNCCCNC(=O)c1c[nH]c(-c2cc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)ccn2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O,val
US04911748,CC(C)CC1NC(=O)N(c2cc(F)ccc2F)C1=O.CI>>CC(C)CC1C(=O)N(c2cc(F)ccc2F)C(=O)N1C,,CN(C)C=O,O,[H-].[Na+],,val
US20130072473A1,CC(=O)Nc1sc2c(c1-c1nc3cc(Cl)ccc3s1)CCN(C(=O)OC(C)(C)C)C2.O=C(O)C(F)(F)F>>CC(=O)Nc1sc2c(c1-c1nc3cc(Cl)ccc3s1)CC[NH2+]C2.O=C([O-])C(F)(F)F,,ClCCl,,,,val
US20040106604A1,CCOC(=O)c1c(-c2cccc(C)n2)nn2c1CCC2>>Cc1cccc(-c2nn3c(c2C(=O)O)CCC3)n1,,CCO,,[Na+].[OH-],,val
US20140332758A1,COc1ccc(-c2ccncc2)c(-c2ccncc2)c1>>COc1ccc2c3ccncc3c3cnccc3c2c1,,Cc1ccccc1,,C1=CCCCC1,,val
US20140275070A1,O=P(Cl)(Cl)Cl.O=c1[nH]cnc2sc(CC(F)(F)F)cc12>>FC(F)(F)Cc1cc2c(Cl)ncnc2s1,CN(C)C=O,,,,,val
US20080039504A1,CC(C)N.N#CBr.NNC(=O)c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>CC(C)n1c(N)nnc1-c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1,,CC(=O)O,,,,val
US04749713,C1CCOC1.N#Cc1ccc(C(CCCCl)n2ccnc2)cc1>>N#Cc1ccc(C2(n3ccnc3)CCCC2)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20090234132A1,Cc1nc(N)sc1-c1ccc(S(C)(=O)=O)c(F)c1.O=C(n1ccnc1)n1ccnc1>>Cc1nc(NC(=O)n2ccnc2)sc1-c1ccc(S(C)(=O)=O)c(F)c1,,ClCCl,,,,val
US20120277224A1,CC(=O)n1ncc2cc(C(=O)O)ccc21.CC1(C)OC(=O)CC(=O)O1>>CC(=O)n1ncc2cc(C(=O)C3C(=O)OC(C)(C)OC3=O)ccc21,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20140163023A1,C[C@H]1COCCN1c1nc2c(c(-c3ccc(NC(=O)NC4CC4)cc3)n1)CNC2.O=C(O)C1CCCO1>>C[C@H]1COCCN1c1nc2c(c(-c3ccc(NC(=O)NC4CC4)cc3)n1)CN(C(=O)C1CCCO1)C2,,CO,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100197668A1,CCCC(N)CCC.CCOC(=O)c1cccn1CCCBr>>CCCC(CCC)NCCCn1cccc1C(=O)OCC,,CC#N,,[I-].[K+],,val
US20130053359A1,CC(C)[Si](C)(C)Cl.CN(C)C=O.COc1cc(N)c(Cl)cc1CO>>COc1cc(N)c(Cl)cc1CO[Si](C)(C)C(C)(C)C,,CN(C)C=O,,c1c[nH]cn1,,val
US20040204584A1,COc1ccc(C2COCCO2)c2sc(N)nc12.COc1cccc(C(=O)O)c1>>COc1cccc(C(=O)Nc2nc3c(OC)ccc(C4COCCO4)c3s2)c1,,C1CCOC1,ClC(Cl)Cl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04782079,CC(=O)Cl.Oc1ccc(-c2ccc(C=C(Br)Br)s2)cc1>>CC(=O)Oc1ccc(-c2ccc(C=C(Br)Br)s2)cc1,,C1CCOC1,CCOCC,CCN(CC)CC,,val
US20150152131A1,C=O.CON=C[C@H](F)[C@H](OCc1ccc(OC)cc1)[C@@H](Br)COCc1ccc(OC)cc1>>COc1ccc(COC[C@H](Br)[C@@H](OCc2ccc(OC)cc2)[C@H](F)C=O)cc1,,CC(C)=O,CCOC(C)=O,Cl,O=C([O-])O.[Na+],val
US20070232645A1,CC(=O)Nc1cc(F)c(Sc2ccc(C)cc2[N+](=O)[O-])c(F)c1>>CC(=O)Nc1cc(F)c(Sc2ccc(C)cc2N)c(F)c1,[Fe],,,[Cl-].[NH4+],,val
US20100135999A1,CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(O)c3ccccc3n2)CC1.O=C(CBr)OCc1ccccc1>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)OCc3ccccc3)c3ccccc3n2)CC1,,O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20160264518A1,CCOC(=O)/C(F)=C/c1ccccc1NC(=O)c1cccc(C(F)(F)F)c1.NO>>O=C(NO)/C(F)=C/c1ccccc1NC(=O)c1cccc(C(F)(F)F)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20120208859A1,C=CCOc1cc(F)c(F)c(F)c1[N+](=O)[O-].Nc1ccc(I)cc1F>>C=CCOc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1[N+](=O)[O-],,C1CCOC1,CCOC(C)=O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20090209607A1,COC(=O)c1cc(-c2c(C)cnn2C)c(C)s1>>Cc1cnn(C)c1-c1cc(C(=O)O)sc1C,,C1CCOC1,,[Na+].[OH-],,val
US20120251551A1,CC1(C)CNC(=O)C1.N#Cc1ccc(Cl)nc1>>CC1(C)CC(=O)N(c2ccc(C#N)cn2)C1,,Cc1ccccc1,,[H-].[Na+],,val
US20020137932A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C(=CCC(C)(C)C)NC(=O)OCc1ccccc1>>COC(=O)C(CCC(C)(C)C)NC(=O)OC(C)(C)C,[Pd],CO,,,,val
US05374646,COc1ccc(O)c(C=O)c1.N#Cc1ccccc1CBr>>Cc1ccc2oc(-c3ccccc3C#N)cc2c1,,CCO,CN(C)C=O,C[O-].[Na+],,val
US20080255202A1,COCCN(Cc1ccc(SC(C)(C)C(=O)OC(C)(C)C)cc1)Cc1nc(-c2ccc(C)cc2C)no1>>COCCN(Cc1ccc(SC(C)(C)C(=O)O)cc1)Cc1nc(-c2ccc(C)cc2C)no1,,C1COCCO1,Cl,,,val
US20080070928A1,CS(=O)(=O)c1ccc(Oc2cc([N+](=O)[O-])c(N)cc2Oc2ccccc2C#N)cn1>>CS(=O)(=O)c1ccc(Oc2cc(N)c(N)cc2Oc2ccccc2C#N)cn1,[Ni],CO,,[H][H],,val
US20110166116A1,CC(C)(C)OC(=O)N1CCC(ON=C2CCN(c3cc(F)c(Br)cc3F)CC2)CC1>>Fc1cc(N2CCC(=NOC3CCNCC3)CC2)c(F)cc1Br,,ClCCl,O=C(O)C(F)(F)F,,,val
US05387585,ClCc1nc(Cl)c2ccccc2n1.NN>>NNc1nc(CCl)nc2ccccc12,,C1CCOC1,,O,,val
US20160186094A1,CCCCCCCCCCC(C)c1ccc(COCCOCCOCCOC2CCCCO2)cc1>>CCCCCCCCCCC(C)c1ccc(COCCOCCOCCO)cc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US06165944,CC(C)(CCl)NC(=O)c1c(S(C)(=O)=O)ccc(C(=O)Cl)c1Cl.Cn1nccc1O>>Cn1ncc(C(=O)c2ccc(S(C)(=O)=O)c(C3=NC(C)(C)CO3)c2Cl)c1O,,C1COCCO1,,CCN(CC)CC,,val
US20060148811A1,CC(=O)Nc1ccc(CCl)cc1.Cl.Cl.O=C(CCN1CCNCC1)c1ccccc1>>CC(=O)Nc1ccc(CN2CCN(CCC(=O)c3ccccc3)CC2)cc1.Cl.Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090099207A1,CCCN1C(=O)OC[C@@H]1Cc1cc(CC2CS(=O)(=O)CC(C(=O)OC)C2O)ccc1OC>>CCCN1C(=O)OC[C@@H]1Cc1cc(CC2CS(=O)(=O)CC(C(=O)O)C2O)ccc1OC,,C1COCCO1,,Cl,[Na+].[OH-],val
US20110124618A1,CCOC(=O)c1cc(-c2cccc(F)c2)n(-c2cccc(OC)c2)n1>>COc1cccc(-n2nc(C(=O)O)cc2-c2cccc(F)c2)c1,,C1COCCO1,O,[Li+].[OH-],,val
US20140206681A1,O=C1CCC(=O)N1Br.O=C1OC[C@H]2CC[C@H](c3ncc4c(Cl)nccn34)CN12>>O=C1OC[C@H]2CC[C@H](c3nc(Br)c4c(Cl)nccn34)CN12,,CN(C)C=O,,,,val
US20130190312A1,COCCOc1ccc(Oc2cc(C)c(-c3csc(N)n3)c(C)c2)cc1.O=C(Cl)c1ccncc1>>COCCOc1ccc(Oc2cc(C)c(-c3csc(NC(=O)c4ccncc4)n3)c(C)c2)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US06218376B1,CCOC(=O)c1nc(C)oc1CCc1cccc(Cl)c1>>Cc1nc(C(=O)O)c(CCc2cccc(Cl)c2)o1,,CCO,O,[K+].[OH-],,val
US20040023964A1,O=[N+]([O-])c1ccc(F)c(-n2ccnc2)c1>>Nc1ccc(F)c(-n2ccnc2)c1,,CCO,,Cl[Sn]Cl,,val
US20070032481A1,CC(=O)N1CCc2nc(C(C)C)nc(-c3ccc(F)cc3)c2C1>>CC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2,,Cl,,,,val
US20110021518A1,CCOC(=O)c1cn2ncnc(N)c2c1-c1ccc(Nc2nc3cc(F)cc(F)c3[nH]2)cc1>>Nc1ncnn2cc(C(=O)O)c(-c3ccc(Nc4nc5cc(F)cc(F)c5[nH]4)cc3)c12,,C1CCOC1,CO,[Na+].[OH-],,val
US20090181963A1,CCCC=O.CN(C)CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3nnn(C4CCNCC4)c3n2)cc1>>CCCCN1CCC(n2nnc3c(N4CCOCC4)nc(-c4ccc(NC(=O)NCCN(C)C)cc4)nc32)CC1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US04207419,CC(C)(C(=O)/C=C/Br)c1ccccc1>>CC(C)(c1ccccc1)C(O)/C=C/Br,,CO,,[BH4-].[Na+],,val
US20140206681A1,CC(F)(F)c1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1Br.CC1(C)OB(c2ccc(C(N)=O)cc2)OC1(C)C>>CC(F)(F)c1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1B1OC(C)(C)C(C)(C)O1,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20120122887A1,C(=NC1CCCCC1)=NC1CCCCC1>>c1ccc2[nH]cnc2c1,,Cc1ccccc1,,,,val
US05759956,CCOC(=O)c1cnccn1.OO>>CCOC(=O)c1c[n+]([O-])ccn1,,CC(=O)O,,CCO,,val
US20080318989A1,Nc1ccccc1Nc1nc(Cl)ncc1Cl.O=C(Cl)C1CC1>>O=C(Nc1ccccc1Nc1nc(Cl)ncc1Cl)C1CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080261917A1,CCCN1C(=O)c2ccccc2C1(Cl)c1ccc(Cl)cc1.SCc1ccccc1>>CCCN1C(=O)c2ccccc2C1(SCc1ccccc1)c1ccc(Cl)cc1,,CO,,CCOC(C)=O,,val
US06660861B1,CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1.O=[Pt]=O>>CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3cc(O)ccc3nc2-1,O=[Pt]=O,,,CC(=O)O,[H][H],val
US20020091264A1,CC(C)NC(C)C.CCOC(=O)OCC.Cc1cccc(NCC(=O)OC(C)(C)C)n1.[Li]CCCC>>CC(C)[N-]C(C)C.CCOC(=O)Cc1cccc(NCC(=O)OC(C)(C)C)n1.[Li+],,C1CCOC1,,,,val
US20120208788A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1c(OC(F)(F)F)ccc(O)c1C(=O)Oc1ccccc1>>Cc1c(OC(F)(F)F)ccc(OC(=O)OC(C)(C)C)c1C(=O)Oc1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US03931235,CCCCCCSc1c(O)cc(C)oc1=O.OO>>CCCCCCS(=O)c1c(O)cc(C)oc1=O,,CC(=O)O,,,,val
US20050038076A1,COc1ccc([N+](=O)[O-])c(NS(=O)(=O)c2ccc(OCC(N)=O)cc2)c1>>COc1ccc(N)c(NS(=O)(=O)c2ccc(OCC(N)=O)cc2)c1,O=[Pt]=O,CC(=O)N(C)C,,[H][H],,val
US20090111860A1,Cc1cc([C@@H](Cc2ccccc2)NS(=O)(=O)c2ccc(Cl)cc2)no1.O=C1CCC(=O)N1Br>>Cc1onc([C@@H](Cc2ccccc2)NS(=O)(=O)c2ccc(Cl)cc2)c1Br,,CN(C)C=O,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20070155721A1,CCOC(=O)c1cc2c(Oc3cc(F)ccc3N)cccc2[nH]1>>CCOC(=O)c1cc2c(Oc3cccc(F)c3)cccc2[nH]1,,CCOCC,CN(C)C=O,CC(C)(C)ON=O,,val
US20060122396A1,CCO.COc1c(F)ccc(C(=O)O)c1F>>CCOC(=O)c1ccc(F)c(OC)c1F,,Cc1ccccc1,,CN(C)C=O,O=S(Cl)Cl,val
US04960779,CC(=O)CCN(C)C.COc1ccc2ccc(N3C(=O)c4ccccc4C3O)nc2n1>>COc1ccc2ccc(N3C(=O)c4ccccc4C3CC(=O)CCN(C)C)nc2n1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20130184254A1,Fc1ccc(-n2ncc3c(I)ccnc32)cc1.O=C1CCC(=O)N1Cl>>Fc1ccc(-n2nc(Cl)c3c(I)ccnc32)cc1,,CCOC(C)=O,CN(C)C=O,,,val
US03979202,C/C=C/C(=O)Nc1cccc(O)c1.O=C=Nc1ccc(Cl)c(Cl)c1>>C/C=C/C(=O)Nc1cccc(OC(=O)Nc2ccc(Cl)c(Cl)c2)c1,,CCOC(C)=O,,CCN(CC)CC,,val
US20080269286A1,Fc1ccc(-c2ccncc2)c(Cl)c1>>Fc1ccc(C2CCNCC2)c(Cl)c1,O=[Pt],CO,,,,val
US04115348,Nc1ccccc1O.O=Cc1ccc(O)cc1>>Oc1ccc(-c2nc3ccccc3o2)cc1,,O=[N+]([O-])c1ccccc1,,,,val
US20090054437A1,NC(=NO)c1ccncc1.O=C(O)c1cc(OCc2ccccc2)c(OCc2ccccc2)c([N+](=O)[O-])c1>>O=[N+]([O-])c1cc(-c2nc(-c3ccncc3)no2)cc(OCc2ccccc2)c1OCc1ccccc1,,CN(C)C=O,,,,val
US04891372,COc1cc([N+](=O)[O-])ccc1C(=O)O.O=C(Cl)C(=O)Cl>>COc1cc([N+](=O)[O-])ccc1C(=O)Cl,CN(C)C=O,ClCCl,,O,,val
US05994390,COc1ccc2c(c1)OC[C@@H](c1ccc(F)cc1)[C@H]2c1ccc(OCCN2CCCC2)cc1>>COc1ccc2c(c1)OC[C@@H](c1ccc(F)cc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1,,CS(C)=O,O,[K+].[OH-],,val
US20140228361A1,C#Cc1cc(Nc2ncnc3cc(OC)c(OCCCN4CC5CN(C(=O)OC(C)(C)C)CC5C4)cc23)ccc1F>>C#Cc1cc(Nc2ncnc3cc(OC)c(OCCCN4CC5CNCC5C4)cc23)ccc1F,,CCOC(C)=O,ClCCl,Cl,,val
US20090181991A1,Nc1cccc([N+](=O)[O-])c1.O=C(Cl)C1CC1>>O=C(Nc1cccc([N+](=O)[O-])c1)C1CC1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US05807859,CC(=O)OC(C)=O.COC(=O)c1cccc(C=O)c1.O=c1[nH]c2c(n3ccnc13)Cc1ccccc1-2>>CC(=O)O.COC(=O)c1cccc(C=c2c3ccccc3c3[nH]c(=O)c4nccn4c23)c1,,CC(=O)OC(C)=O,,C,O=C[O-].[NH4+],val
US20060205728A1,COC(=O)c1nnc(C(=O)N2CCCCC2)cc1CC(C)C.NN>>CC(C)Cc1cc(C(=O)N2CCCCC2)nnc1C(=O)NN,,CCO,,O,,val
US20040248875A1,O=C(O)CCc1cnn2c1NCCC2.O=CO>>O=CN1CCCn2ncc(CCC(=O)O)c21,,O=CO,,CC(=O)OC(C)=O,,val
US20040209921A1,COC(=O)c1cc(C#N)ccc1CN(Cc1ncc(C)cc1C)S(=O)(=O)c1ccccc1[N+](=O)[O-]>>Cc1cnc(CN(Cc2ccc(C#N)cc2CO)S(=O)(=O)c2ccccc2[N+](=O)[O-])c(C)c1,,C1CCOC1,CO,[BH4-].[Li+],,val
US20090281088A1,CC1(C)OB(c2ccc(CO[C@@H]3COc4nc([N+](=O)[O-])cn4C3)nc2)OC1(C)C.O=C1O[C@@H](Cn2ccnn2)CN1c1ccc(I)c(F)c1>>O=C1O[C@H](Cn2ccnn2)CN1c1ccc(-c2ccc(CO[C@H]3COc4nc([N+](=O)[O-])cn4C3)nc2)c(F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20160159820A1,CC(C)(C)OC(=O)N[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3[C@@H]21.Cl>>Cl.N[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3[C@@H]21,,CCOC(C)=O,,,,val
US20160039745A1,C1=COCCC1.Cc1c(F)cccc1[C@]1(C(=O)O)CC[C@@H](c2ccc3cn[nH]c3c2F)C1>>Cc1c(F)cccc1[C@]1(C(=O)O)CC[C@@H](c2ccc3cnn(C4CCCCO4)c3c2F)C1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20060257987A1,CCc1ccc(OC)cc1.O=C(Cl)c1ccccc1>>CCc1ccc(O)c(C=O)c1,,Cc1ccccc1,ClCCl,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20030069233A1,COc1ccc(N)cc1N1CCN(C)CC1.O=S(=O)(Cl)c1cccs1>>COc1ccc(NS(=O)(=O)c2cccs2)cc1N1CCN(C)CC1,,CC(C)=O,,,,val
US20040157890A1,Cc1cc(CCc2sc(-c3ccc(C#N)c(F)c3)cc2C)ccc1OCC12OCC(C)(CO1)CO2>>Cc1cc(CCc2sc(-c3ccc(C#N)c(F)c3)cc2C)ccc1OCC(=O)O,,CC(C)O,,Cl,,val
US20130225620A1,CC(=O)c1cc2ncn(C3CCCCO3)c2cc1C.NO>>CC(=NO)c1cc2ncn(C3CCCCO3)c2cc1C,,CO,,Cl,CC(=O)[O-].[Na+],val
US20110245224A1,C[C@H]1CN(c2c(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc(C(O)c3cncn3C)c(F)c2F)C[C@@H](C)O1>>C[C@H]1CN(c2c(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc(C(=O)c3cncn3C)c(F)c2F)C[C@@H](C)O1,O=[Mn]=O,ClCCl,,,,val
US20150111885A1,CCOC(=O)COc1ccc(F)cc1F.CCOC=O.CS(=O)(=O)CC(=N)N>>CS(=O)(=O)Cc1ncc(Oc2ccc(F)cc2F)c(O)n1,,C1CCOC1,,[H-].[Na+],,val
US20080085890A1,CI.O=[N+]([O-])c1ccc(N2CCC(CO)CC2)cc1>>COCC1CCN(c2ccc([N+](=O)[O-])cc2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20080045532A1,CCN.O=C(O)c1ccc(-n2nc(C(F)(F)F)c3c2CCCC3)cc1>>CCNC(=O)c1ccc(-n2nc(C(F)(F)F)c3c2CCCC3)cc1,,C1CCOC1,ClCCl,O=C(n1ccnc1)n1ccnc1,,val
US20100216746A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1nc(Cl)c(C(=O)NCc2ccc(Cl)c(Oc3cc(C#N)cc(C4CC4)c3)c2F)[nH]1.O=C(O)C(F)(F)F>>N#Cc1cc(Oc2c(Cl)ccc(CNC(=O)c3[nH]c(N)nc3Cl)c2F)cc(C2CC2)c1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US04558130,CCOC(=O)CC(=O)OCC.CN(C)c1ccc(C=O)c([N+](=O)[O-])c1>>CCOC(=O)C(=Cc1ccc(N(C)C)cc1[N+](=O)[O-])C(=O)OCC,,Cc1ccccc1,,C1CCNCC1,CC(=O)O,val
US20160251380A1,CC(C)(O)COc1cccc(C=O)c1B1OC(C)(C)C(C)(C)O1.C[N+](=O)[O-]>>CC1(C)OB2OC(C[N+](=O)[O-])C=C3C=COCC1=C23,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20140275130A1,CC(C)(C)OC(=O)N1CCc2nc3c(C(=O)On4nnc5ccccc54)c(N)nn3cc2C1.Cc1nsc(N)c1C1CC1>>Cc1nsc(NC(=O)c2c(N)nn3cc4c(nc23)CCN(C(=O)OC(C)(C)C)C4)c1C1CC1,,CCOC(C)=O,c1ccncc1,,,val
US20090298894A1,BrCc1ccccc1.Cc1cc(O)cc(=O)o1>>Cc1cc(OCc2ccccc2)cc(=O)o1,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20080161289A1,N#Cc1ccc(-c2nc3c(s2)CCNCC3)nc1.O=C1CCC1>>N#Cc1ccc(-c2nc3c(s2)CCN(C2CCC2)CC3)nc1,CC(=O)O,CO,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120028939A1,COc1cc(C#N)cc(OC)c1O.ClCCN1CCOCC1>>COc1cc(C#N)cc(OC)c1OCCN1CCOCC1,,CC(=O)N(C)C,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120295874A1,CC(C)(C)OC(=O)NCc1ccc(C(=O)NCc2ccc(OCC(=O)N3C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)C3)cc2)cc1>>NCc1ccc(C(=O)NCc2ccc(OCC(=O)N3C[C@H](O)[C@@H](O)C3)cc2)cc1,,CCOCC,ClCCl,Cl,,val
US20150005282A1,COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)cc(OC5CNC5)cc4C)c3)ccc21.O=C(Cl)C1CC1>>COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)cc(OC5CN(C(=O)C6CC6)C5)cc4C)c3)ccc21,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US04652666,CC(Oc1ccc(Cl)cc1)C(=O)Cl.CCCCCC(=NO)P(=O)(OCC)OCC>>CCCCCC(=NOC(=O)C(C)Oc1ccc(Cl)cc1)P(=O)(OCC)OCC,,Cc1ccccc1,,CCN(CC)CC,,val
US20100204234A1,Nc1nccs1.O=C(O)c1cccc(-c2c(O)ccc3cc(-c4cccc(O)c4)ccc23)c1>>O=C(Nc1nccs1)c1cccc(-c2c(O)ccc3cc(-c4cccc(O)c4)ccc23)c1,,COCCOC,ClCCl,O=S(Cl)Cl,,val
US20110306607A1,CCOC(OCC)C1C(=O)c2ccccc2OC12CCN(C(=O)OCc1ccccc1)CC2>>O=C1C(=CO)C2(CCN(C(=O)OCc3ccccc3)CC2)Oc2ccccc21,,CC(C)=O,,II,,val
US20120035168A1,Cc1cc(NC(=O)OC(C)(C)C)nc(C)c1CN.O=C(O)c1cn(Cc2ccc(Cn3cccn3)cc2)cn1>>Cc1cc(NC(=O)OC(C)(C)C)nc(C)c1CNC(=O)c1cn(Cc2ccc(Cn3cccn3)cc2)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030069242A1,FC(F)(F)c1cc[nH]n1.N#Cc1ccc(F)cc1Cl>>N#Cc1ccc(-c2c[nH]nc2C(F)(F)F)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130274255A1,COc1ccc(B(O)O)cc1OC.C[Si](C)(C)CCOCn1nc(-c2ccc(Br)cc2)c2c1-c1ccsc1C2>>COc1ccc(-c2ccc(-c3nn(COCC[Si](C)(C)C)c4c3Cc3sccc3-4)cc2)cc1OC,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20120196872A1,CI.COC(=O)CN1C(=O)C2(COCCOC2)NC[C@H]1c1cc(F)cc(F)c1>>COC(=O)CN1C(=O)C2(COCCOC2)N(C)C[C@H]1c1cc(F)cc(F)c1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US04853404,CCOC(=O)CBr.CCOCn1nccc1C(=O)c1ccc(O)c(Cl)c1Cl>>CCOCn1nccc1C(=O)c1ccc(OCC(=O)OCC)c(Cl)c1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050096337A1,O=S(Cl)Cl.OCc1cnc(-c2ccc(C(F)(F)F)cc2)nc1C(F)(F)F>>FC(F)(F)c1ccc(-c2ncc(CCl)c(C(F)(F)F)n2)cc1,,ClCCl,,,,val
US20070259965A1,CC(C)(C)OC(=O)NCC[C@H](CO)NC(=O)OCc1ccccc1.O=S(=O)(Cl)c1ccc(F)cc1Cl>>CC(C)(C)OC(=O)NCC[C@H](CO)NS(=O)(=O)c1ccc(F)cc1Cl,[Pd],CCO,,[H][H],,val
US05576321,Cc1cccc(C)c1N1CCNCC1.O=C(O)C(=O)O.c1cc(OC[C@@H]2CO2)c2cc[nH]c2c1>>Cc1cccc(C)c1N1CCN(C[C@H](O)COc2cccc3[nH]ccc23)CC1.O=C(O)C(=O)O,,CCOC(C)=O,,CO,,val
US20080287396A1,CCOP(=O)(OCC)C(NC(=O)CBr)P(=O)(OCC)OCC.COc1c(N2C[C@@H]3[C@@H](CCCN3C(=O)OC(C)(C)C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12>>CCOP(=O)(OCC)C(NC(=O)COC(=O)c1cn(C2CC2)c2c(OC)c(N3C[C@@H]4[C@@H](CCCN4C(=O)OC(C)(C)C)C3)c(F)cc2c1=O)P(=O)(OCC)OCC,,O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110201605A1,Cc1cc(Cc2ccccc2)nc(NC2CCNCC2)n1.Clc1nsc(Cl)n1>>Cc1cc(Cc2ccccc2)nc(NC2CCN(c3nc(Cl)ns3)CC2)n1,,C1CCOC1,O,CCN(C(C)C)C(C)C,Cl,val
US20140228386A1,CC(=O)CSc1ccc(F)c(Br)c1>>Cc1csc2cc(Br)c(F)cc12,,Cc1ccccc1,,,,val
US20110144068A1,COc1ccc(CCl)cc1.O=[N+]([O-])c1cccc(-c2n[nH]cc2I)c1>>COc1ccc(Cn2cc(I)c(-c3cccc([N+](=O)[O-])c3)n2)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20030036544A1,Fc1cccc(F)c1-c1cnc(-c2ccc(Br)cc2)nn1.OB(O)Oc1ccc(OC(F)(F)F)cc1>>Fc1cccc(F)c1-c1cnc(-c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)nn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,[Na+].[OH-],,val
US20120232051A1,CNc1cnccc1-c1ccccc1C.O=C(O)c1cc(C(F)(F)F)cc(C(F)(F)F)n1>>Cc1ccccc1-c1ccncc1N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)n1,,CCCCCCC,CCOC(C)=O,,,val
US20150045349A1,CC(=O)CC(=O)NC1CCCCC1C.COC(OC)N(C)C>>CC(=O)C(=CN(C)C)C(=O)NC1CCCCC1C,,CN(C)C=O,,,,val
US20160176868A1,CCn1c(=O)[nH]c2c(c1=O)C(=O)C[C@H](c1cccc(Cl)c1)N2>>CCn1c(=O)[nH]c2c(c1=O)CC[C@H](c1cccc(Cl)c1)N2,,C1CCOC1,,[BH4-].[Li+],,val
US20140336224A1,COC(=O)CBr.N#CCCC(c1ccc(Cl)cc1F)c1n[nH]c2ccccc12>>COC(=O)Cn1nc(C(CCC#N)c2ccc(Cl)cc2F)c2ccccc21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100144707A1,CC(C)(C)OC(=O)n1ncc2cc(Nc3nc(-c4cccc(NC(=O)[C@H]5CCCN5C(=O)C(F)(F)F)c4)nc4ccccc34)ccc21>>CC(C)(C)OC(=O)n1ncc2cc(Nc3nc(-c4cccc(NC(=O)[C@H]5CCCN5)c4)nc4ccccc34)ccc21,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20100227880A1,C1CCNC1.C=O.CN(Cc1cn2ccccc2n1)[C@H]1CCCc2cccnc21>>CN(Cc1nc2ccccn2c1CN1CCCC1)[C@H]1CCCc2cccnc21,,CC(=O)O,,O,,val
US20090275570A1,CN(c1ncc(C(N)=O)c2sc(-c3ccccc3OCc3ccccc3)cc12)[C@H]1CCCN(C(=O)OC(C)(C)C)C1>>CN(c1ncc(C(N)=O)c2sc(-c3ccccc3OCc3ccccc3)cc12)[C@H]1CCCNC1,,C1COCCO1,CO,Cl,,val
US20040044008A1,Cc1cccc(C(=O)Nc2ccc(N3CCNCC3)cc2)c1-c1ccc(C(C)C)cc1.NC(=O)CBr>>Cc1cccc(C(=O)Nc2ccc(N3CCN(CC(N)=O)CC3)cc2)c1-c1ccc(C(C)C)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060287291A1,COc1ccc(C)cc1S(=O)(=O)c1cc(CO)c2occc2c1.O=C(Cl)C(=O)Cl>>COc1ccc(C)cc1S(=O)(=O)c1cc(CCl)c2occc2c1,,ClCCl,,CN(C)C=O,,val
US20100317651A1,CC(C)N(C)c1cnc2c(n1)OCCN(Cc1ccccc1)C2.O=C1CCC(=O)N1Br>>CC(C)N(C)c1nc2c(nc1Br)CN(Cc1ccccc1)CCO2,,O,,CC#N,,val
US20020091148A1,NNC(=O)c1[nH]c2ccccc2c1-c1ccsc1.O=Cc1ncc[nH]1>>O=C(NN=Cc1ncc[nH]1)c1[nH]c2ccccc2c1-c1ccsc1,,CCO,,,,val
US20130259850A1,Cc1cccc(C)c1COc1cccc(C2(C=O)CC2)c1.O=[Cr](=O)=O>>Cc1cccc(C)c1COc1cccc(C2(C(=O)O)CC2)c1,,CC(C)=O,CCOC(C)=O,O=S(=O)(O)O,,val
US05155113,O=C(Cl)Cc1ccccc1.O=c1cc(O)c(Cl)c[nH]1>>O=C(Cc1ccccc1)Oc1cc(=O)[nH]cc1Cl,,c1ccncc1,,,,val
US20090257979A1,CC(C)CCBr.COC(=O)c1c[nH]c2ccccc12>>COC(=O)c1cn(CCC(C)C)c2ccccc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04988723,CC1(C)Oc2ccc(C#N)cc2[C@@H](N)[C@@H]1O.Cc1ccc(C(=O)[C@](O)(C(=O)O)[C@@](O)(C(=O)O)C(=O)c2ccc(C)cc2)cc1>>CC1(C)Oc2ccc(C#N)cc2[C@@H](N)[C@@H]1O.Cc1ccc(C(=O)[C@](O)(C(=O)O)[C@@](O)(C(=O)O)C(=O)c2ccc(C)cc2)cc1,,CCO,,O,,val
US04358451,CCOC(=O)CC1NCCc2c1[nH]c1ccccc21.CCOCC.N#C[O-]>>CN1C(=O)CC2c3[nH]c4ccccc4c3CCN2C1=O,,O,,Cl,,val
US20040266789A1,CCCCc1oc2ccccc2c1Cc1ccc(-c2ccc(OCCCc3ccccc3)c([N+](=O)[O-])c2)cc1>>CCCCc1oc2ccccc2c1Cc1ccc(-c2ccc(OCCCc3ccccc3)c(N)c2)cc1,[Fe],CC(=O)O,CCO,,,val
US20100261900A1,C#CC1=CCCCC1.Cc1ccc(S(=O)(=O)Oc2cc(-c3ccccc3)nn2C)cc1>>Cn1nc(-c2ccccc2)cc1C#CC1=CCCCC1,,CCCCCCC,ClCCl,,,val
US05393730,NNc1ccc(C(F)(F)F)cc1.O=C(O)c1cccnc1C(=O)c1cccc(C(F)(F)F)c1>>O=C(c1cccc(C(F)(F)F)c1)c1ncccc1C(O)=NNc1ccc(C(F)(F)F)cc1,Cc1ccc(S(=O)(=O)O)cc1,CO,,,,val
US06720424B1,COC(=O)c1cc([N+](=O)[O-])ccc1Cl.CS>>COC(=O)c1cc([N+](=O)[O-])ccc1SC,,CN(C)C=O,,O,[Na],val
US20120015943A1,COC(=O)c1ccc2c(c1)CCC(c1ccc(OC)cc1)=C2>>COC(=O)c1ccc2c(c1)CCC(c1ccc(OC)cc1)C2,[Pd],C1CCOC1,CCO,,,val
US04690943,CC(=O)N1C(=O)Cc2cc(Cl)ccc21.O=C(Cl)c1cccs1>>CC(=O)N1C(=O)C(C(=O)c2cccs2)c2cc(Cl)ccc21,CN(C)c1ccncc1,CN(C)C=O,,,,val
US04386073,CC(C)C[C@H](NC(=O)[C@@H]1CCC(=O)N1C(=O)OCc1ccccc1)C(=O)N1CCC[C@@H]1C(N)=O>>CC(C)C[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@@H]1C(N)=O,[Pd],CO,,[H][H],,val
US06242432B1,CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1.Cl>>CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1.Cl,,CC(C)O,,,,val
US20100216846A1,CC(=O)OC(C)=O.CC[C@H](O)Cn1nc(Nc2cc(OC)cc(C(F)(F)F)c2)nc1-c1cc(C)nc(Cl)c1>>CC[C@@H](Cn1nc(Nc2cc(OC)cc(C(F)(F)F)c2)nc1-c1cc(C)nc(Cl)c1)OC(C)=O,CN(C)c1ccncc1,,,,,val
US20100120763A1,Cc1cn(-c2cc(C(F)(F)F)cc(Cl)c2N)cn1.O=N[O-]>>Cc1ncn2c1nnc1c(Cl)cc(C(F)(F)F)cc12,,CC(=O)O,,[Na+].[OH-],,val
US20050131017A1,COC(=O)c1ccc(C)nc1>>Cc1ccc(C=O)cn1,,C1CCOC1,,CCOC(C)=O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20080269280A1,COCCNCC(=O)N1CC(=O)N(c2cccc(Cl)c2C)C1.O=C=Nc1cccc(Cl)c1>>COCCN(CC(=O)N1CC(=O)N(c2cccc(Cl)c2C)C1)C(=O)Nc1cccc(Cl)c1,,C1CCOC1,,,,val
US20100197591A1,CC(C)(C)C(O)c1ccc(Br)cc1.CC(C)(C)[Si](C)(C)Cl>>CC(C)(C)C(O[Si](C)(C)C(C)(C)C)c1ccc(Br)cc1,,CN(C)C=O,,,,val
US20110269737A1,CN1CCNCC1.COc1c(NC(=O)c2cc3cccc(CN4CCC(C(=O)O)CC4)c3n2C)cc(C(C)(C)C)cc1NS(C)(=O)=O>>COc1c(NC(=O)c2cc3cccc(CN4CCC(C(=O)N5CCN(C)CC5)CC4)c3n2C)cc(C(C)(C)C)cc1NS(C)(=O)=O,,C1CCOC1,,,,val
US20050153987A1,O=C1Cc2cc(-c3cccnc3)ccc2N1.[O-][n+]1cc(CN2CCOCC2)ccc1Cl>>[O-][n+]1cc(CN2CCOCC2)ccc1-c1c(O)[nH]c2ccc(-c3cccnc3)cc12,,CN(C)C=O,,[H-].[Na+],,val
US20120196884A1,CN(c1ccc(NC(=O)Nc2ccccc2)cc1)S(=O)(=O)c1ccc(Br)s1.OB(O)c1cccnc1>>CN(c1ccc(NC(=O)Nc2ccccc2)cc1)S(=O)(=O)c1ccc(-c2cccnc2)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US05672609,CNC.COc1ccc(CC(=O)c2ccc(OCc3ccccc3)cc2)cc1>>COc1ccc(C=C(c2ccc(OCc3ccccc3)cc2)N(C)C)cc1,Cl[Ti](Cl)(Cl)Cl,Cc1ccccc1,,CCOCC,,val
US05691369,CNC.O=C1N(CCCCI)CCN1N=Cc1ccccc1>>CN(C)CCCCN1CCN(N=Cc2ccccc2)C1=O,,CN(C)C=O,,Cl,C[O-].[Na+],val
US20140309207A1,CC(C)(C)OC(=O)N1CCC2(C1)CN(C(=O)Nc1ncc(Cl)s1)c1ccc(Br)cc12>>O=C(Nc1ncc(Cl)s1)N1CC2(CCNC2)c2cc(Br)ccc21,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20040248922A1,CC(=O)NC1=CC(=O)c2ccc(C=O)nc2C1=O.CC(c1c[nH]c2ccccc12)[C@H](N)C(=O)OCCN(C)C>>COC(=O)c1cc2c([nH]c3ccccc32)c(-c2ccc3c(n2)C(=O)C(NC(C)=O)=CC3=O)n1,,COc1ccccc1,,,,val
US06358972B1,CC(C)[Si](C(C)C)(C(C)C)n1cc(C2CCN(C)CC2)c2cc(Br)ccc21.OB(O)c1ccc(Cl)cc1>>CN1CCC(c2c[nH]c3ccc(-c4ccc(Cl)cc4)cc23)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US06858739B2,COc1ccc(C=O)cc1[N+](=O)[O-].Nc1cc(Cl)c(Cl)cc1N>>COc1ccc(-c2nc3cc(Cl)c(Cl)cc3[nH]2)cc1[N+](=O)[O-],,CCO,,O=S([O-])O.[Na+],,val
US20050222171A1,CCOC=O.N#CCCc1cccc(Br)c1>>N#CC(C=O)Cc1cccc(Br)c1,,C1CCOC1,O,Cl,[H-].[Na+],val
US20020026060A1,CCCCCNc1ccc2c(c1)C(C)(C)CCC2(C)C.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCCCN(C(=O)Cl)c1ccc2c(c1)C(C)(C)CCC2(C)C,,C1CCOC1,,,,val
US20050038043A1,CC(C)I.CCCc1c(Cn2ccnc2-c2ncccc2F)ncn2nc(O)nc12>>CCCc1c(Cn2ccnc2-c2ncccc2F)ncn2nc(OC(C)C)nc12,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05690858,C=CCCCCCCCCCO.Cc1ccc(S(=O)(=O)Cl)cc1>>C=CCCCCCCCCCOS(=O)(=O)c1ccc(C)cc1,,c1ccncc1,,Cl,,val
US20130079320A1,CCOC(=O)C(C)c1ccc([N+](=O)[O-])c(C)c1>>CCOC(=O)C(C)c1ccc(N)c(C)c1,[Pd],C1CCOC1,CO,,,val
US04885022,CO.COC(=O)c1ccc(S(C)(=O)=O)c(CBr)c1Cl>>COCc1c(S(C)(=O)=O)ccc(C(=O)OC)c1Cl,,CO,,C[O-].[Na+],,val
US04894458,Cc1c(F)c(Br)cc([N+](=O)[O-])c1F>>Cc1c(F)c(N)cc(Br)c1F,[Fe],O,,CCO,Cl,val
US20060058522A1,CC(C)NCc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.NC(=O)Nc1sc(Br)cc1C(N)=O>>CC(C)NCc1ccc(-c2cc(C(N)=O)c(NC(N)=O)s2)cc1,,O,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US06271264B1,C=CCBr.C=CCN1CCCC2CCCCC21>>C=CC[N+]1(CC=C)CCCC2CCCCC21.[Br-],,CCOCC,,,,val
US20100173933A1,O=C(Cl)C(=O)Cl.O=C(O)OCc1ccccc1>>O=C(Cl)COCc1ccccc1,,CN(C)C=O,ClCCl,,,val
US20070082912A1,CC(=O)CCC(=O)c1cc(Cl)ccc1OCc1ccccc1.CS(=O)(=O)c1cccc(N)c1>>Cc1cc(-c2cc(Cl)ccc2OCc2ccccc2)n(-c2cccc(S(C)(=O)=O)c2)c1,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,Cl,val
US20060142263A1,C[C@H]1C(=O)OC[C@@H]1NC(=O)OCc1ccccc1.Cc1cc(N)ccc1N1CCOCC1=O>>Cc1cc(NC(=O)[C@H](C)[C@H](CO)NC(=O)OCc2ccccc2)ccc1N1CCOCC1=O,,C1CCOC1,,C[Al](C)C,,val
US20040224945A1,CCc1cnc(-c2nn(Cc3ccccc3F)c3ncccc23)nc1C1=NCCN1>>CCc1cnc(-c2nn(Cc3ccccc3F)c3ncccc23)nc1-c1ncc[nH]1,[Pd],Cc1ccccc1,,,,val
US20090088425A1,COC(=O)c1ccc(Cl)c(C(C)C(O)(c2cncc(C)n2)C(F)(F)F)c1>>Cc1cncc(C(O)(C(C)c2cc(C(=O)O)ccc2Cl)C(F)(F)F)n1,,CO,,[Na+].[OH-],,val
US04248885,COc1c(S(=O)(=O)Cl)cc(C(=O)O)c2c1OCCO2.N>>COc1c(S(N)(=O)=O)cc(C(=O)O)c2c1OCCO2,,O,,,,val
US04112102,COc1cc(CNCCCNCCCCNCCCNCc2ccc(O)c(OC)c2)ccc1O.Nc1cccc(C2CN3CCN=C3S2)c1.O=C(Cl)c1ccc(Cl)nc1>>COc1cc(CNCCCNCCCCNCCCNCc2ccc(O)c(OC)c2)ccc1O.O=C(Nc1cccc(C2CN3CCN=C3S2)c1)c1ccc(Cl)nc1,,CO,ClCCl,Cl,[Na+].[OH-],val
US05202321,COC(=O)CSc1c(CC(C)(C)C(=O)OC)n(Cc2ccc(Cl)cc2)c2ccc(O)cc12>>COC(=O)C(C)(C)Cc1c(SCC(=O)O)c2cc(O)ccc2n1Cc1ccc(Cl)cc1,,CO,O,[Li+].[OH-],,val
US20130210831A1,C1CCOC1.CC(C)(C)OC(=O)N1CC[C@@H](N)C1.O=C1CCCC1>>CCCCOC(=O)N1CC[C@@H](NC2CCCC2)C1,,C1CCOC1,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20120065204A1,COC(=O)c1ccc2c(c1)CC(C(=O)O)CO2.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COC(=O)c1ccc2c(c1)CC(N)CO2,,CC(C)(C)O,,,,val
US20100130738A1,COc1cccc(NC(=O)OC(C)(C)C)c1[N+](=O)[O-]>>COc1cccc(N)c1[N+](=O)[O-],,ClCCl,,O=C(O)C(F)(F)F,,val
US20140243310A1,O=[N+]([O-])c1ccc(S(=O)(=O)OCC2CC2(F)F)cc1>>O=[N+]([O-])c1ccc(S(=O)(=O)OC[C@H]2CC2(F)F)cc1,,CCCCCC,CCO,,,val
US20110313002A1,Nc1nccs1.O=C(O)[C@H](CC1CCCCC1)N1CC2=C(Oc3c(Cl)cccc3C2)C1=O>>O=C(Nc1nccs1)[C@H](CC1CCCCC1)N1CC2=C(Oc3c(Cl)cccc3C2)C1=O,,ClCCl,O,On1nnc2ccccc21,,val
US20140107073A1,CN.Fc1ccc(-c2ncccc2-c2ccc3ncnc(Cl)c3c2)cc1Cl>>CNc1ncnc2ccc(-c3cccnc3-c3ccc(F)c(Cl)c3)cc12,,C1CCOC1,CC(C)O,,,val
US03962342,CC(C)(C)C(=O)c1ccc(CBr)cc1.[C-]#N>>CC(C)(C)C(=O)c1ccc(CC#N)cc1,,CCO,,O,,val
US20040266839A1,CCN=C=O.NCc1cccc([N+](=O)[O-])c1>>CCNC(=O)NCc1cccc([N+](=O)[O-])c1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20100069504A1,CC(C)(C)OC(=O)NC1CCc2ccccc2C(=Cc2ccccc2)C1=O>>CC(C)(C)OC(=O)NC1CCc2ccccc2C(Cc2ccccc2)C1=O,[Pd],,,,,val
US06066639,CCOC(=O)c1cnc(Br)s1>>O=C(O)c1cnc(Br)s1,,[Na+],[OH-],Cl,,val
US20080242643A1,BrCc1ccccc1.CS(=O)(=O)c1ccc(/C(COC(=O)OCC(CO[N+](=O)[O-])O[N+](=O)[O-])=C(/C(=O)O)c2ccccc2)cc1>>CS(=O)(=O)c1ccc(/C(COC(=O)OCC(CO[N+](=O)[O-])O[N+](=O)[O-])=C(/C(=O)OCc2ccccc2)c2ccccc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100324070A1,CC(C)CCO[N+](=O)[O-].COC(=O)c1cc(N)c(C)c(I)c1>>COC(=O)c1cc(I)c2cn[nH]c2c1,,CC(=O)O,,,,val
US20130131035A1,Clc1ccnc(Cl)c1.Fc1ccc(OC2CNC2)cc1>>Fc1ccc(OC2CN(c3cccc(Cl)n3)C2)cc1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20110046153A1,CCCNC1CCc2ncsc2C1.O=CCCCC(=O)N1CCN(c2ccccc2)CC1>>CCCN(CCCCC(=O)N1CCN(c2ccccc2)CC1)C1CCc2ncsc2C1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20050119246A1,CC(=O)C(Cl)C(C)=O.O=C(OCc1ccccc1)N1CCNCC1>>CC(=O)C(C(C)=O)N1CCN(C(=O)OCc2ccccc2)CC1,,CN(C)C=O,,O,,val
US04792614,C#C[Mg]Br.O=C(CCl)c1ccc(F)cc1>>C#CC1(c2ccc(F)cc2)CO1,,C1CCOC1,,CCOCC,[Na+].[OH-],val
US20030162958A1,CCC(CC)(CO)CO.COc1cscc1OC>>CCC1(CC)COc2cscc2OC1,,Cc1ccccc1,,Cc1ccccc1S(=O)(=O)O,,val
US20120196864A1,CCN(CC)CCN.COc1cc(C=O)ccc1Oc1ccc(C#N)cc1C(F)(F)F.O=C1NC(=S)CS1>>CCN(CC)CCNC1=NC(=O)S/C1=C\c1ccc(Oc2ccc(C#N)cc2C(F)(F)F)c(OC)c1,,CCO,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US05300477,O=C1CCC(=O)N1Br.O=c1cc(C(F)(F)F)nc(-c2ccccc2)[nH]1>>O=c1[nH]c(-c2ccccc2)nc(C(F)(F)F)c1Br,,CC(=O)O,,,,val
US04013708,CCOC(=O)CCCCOc1ccc(C2=CCCCCCC2)cc1>>O=C(O)CCCCOc1ccc(C2=CCCCCCC2)cc1,,CCO,,[Na+].[OH-],,val
US20040198790A1,CC(C)(C)[Si](C)(C)Cl.COc1cccc(CO)c1CO>>COc1cccc(CO[Si](C)(C)C(C)(C)C)c1CO,,C1CCOC1,,O,c1c[nH]cn1,val
US20160271270A1,CC(=O)OC[C@H]1O[C@@H](Oc2cc3c(c4c(C)csc24)[C@H](CCl)CN3C(=O)OC(C)(C)C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@@H](Oc2cc3c(c4c(C)csc24)[C@H](CCl)CN3)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O,,C1COCCO1,,Cl,,val
US04451650,CCOC(=O)C(Cl)C(C)=O.Nc1cnccc1O>>C1=Nc2cnccc2OC1,,CCO,c1ccncc1,,,val
US04086353,Cn1ncc2cccc(N=C=S)c21.NCCO>>Cn1ncc2cccc(NC3=NCCO3)c21,,CCOCC,,,,val
US05780505,CCOc1c(NCc2ccc(C#N)c(CC)c2)c(=O)c1=O.C[C@@H](N)C(C)(C)C>>CCc1cc(CNc2c(NC(C)C(C)(C)C)c(=O)c2=O)ccc1C#N,,CCO,,ClCCl,,val
US04737513,C#CCBr.CCOC(=O)c1c[nH]cc1C(F)(F)F>>C#CCn1cc(C(=O)OCC)c(C(F)(F)F)c1,,C1CCOC1,,O,[H-].[Na+],val
US04299821,NC(=O)[C@H]1CCCCN1C(=O)OCc1ccccc1>>NC(=O)[C@H]1CCCCN1,[Pd],CO,,,,val
US05574042,CNC.Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CN)c3Cl)cccn2c1Cl.O=C(Cl)CBr>>Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CN(C)C)c3Cl)cccn2c1Cl,,ClCCl,,CCN(CC)CC,,val
US20130196002A1,COc1cnc(Cl)nc1OC.OB(O)c1ccc(C(F)(F)F)cc1>>O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)ncc1O,[Pd],C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100061928A1,CCCC[Sn](CCCC)(CCCC)c1ccc2nc3c(C(=O)NCCN(CC)CC)cccc3nc2c1.II>>CCN(CC)CCNC(=O)c1cccc2nc3cc(I)ccc3nc12,,ClC(Cl)Cl,,O=C([O-])[O-].[Na+].[Na+],,val
US20090312383A1,CCC(CC)c1ccc(C(=O)OC)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12>>CCC(CC)c1ccc(CO)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12,,C1CCOC1,,[BH4-].[Li+],,val
US20050054683A1,CC(=O)OCC(=O)N1CCC(c2ccc(N3C[C@H](CNC(=O)C(Cl)Cl)OC3=O)cc2F)CC1>>O=C(NC[C@H]1CN(c2ccc(C3CCN(C(=O)CO)CC3)c(F)c2)C(=O)O1)C(Cl)Cl,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150264932A1,CC(C)(C)N(CCO)CCO.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)N1CCOC(=O)OCC1,,C1CCOC1,,CCN(CC)CC,,val
US20150126490A1,O=C1C=C(c2ccc(F)nc2)CN1>>O=C1CC(c2ccc(F)nc2)CN1,[Pd],CO,,,,val
US20090012055A1,CCO.COCCCOc1cc(COC2CN(C(=O)OC(C)(C)C)CCC2c2ccc(OCCCOCc3ccccc3OC)cc2)ccc1Br.COCCOC>>COCCCOc1cc(COC2CN(C(=O)OC(C)(C)C)CCC2c2ccc(OCCCOCc3ccccc3OC)cc2)ccc1-c1ccco1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20100215579A1,O=[N+]([O-])c1ccc(-c2ccc3cc(O)ccc3c2)cc1.OCCOCCOCCCl>>O=[N+]([O-])c1ccc(-c2ccc3cc(OCCOCCOCCO)ccc3c2)cc1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20040249155A1,COC(=O)[C@H](NC(=O)OC(C)(C)C)[C@H](C)OC>>CO[C@@H](C)[C@@H](NC(=O)OC(C)(C)C)C(=O)O,,C1COCCO1,O,[Li+].[OH-],,val
US20090018160A1,C=O.CCCCCCC(=O)c1cccnc1>>C=C(CCCCC)C(=O)c1cccnc1,,CO,,C1CCNCC1,CC(=O)O,val
US20090036434A1,Cc1nc(NCC2COC(C)(C)O2)ccc1Oc1cc(OC2CCN(C(=O)OC(C)C)CC2)ncn1>>Cc1nc(NCC(O)CO)ccc1Oc1cc(OC2CCN(C(=O)OC(C)C)CC2)ncn1,,C1CCOC1,ClCCl,Cl,,val
US20070142432A1,CC(C)(C)OC(=O)N1CCC(O)CC1.Oc1ccc(Oc2ccc(Cl)cc2)cc1>>Clc1ccc(Oc2ccc(OC3CCNCC3)cc2)cc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150080364A1,CC(C)(C)OC(=O)N1CCN(Cc2cc(C(F)(F)F)ccc2N2CCOCC2)CC1>>FC(F)(F)c1ccc(N2CCOCC2)c(CN2CCNCC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070037781A1,CCC1(CC)OC(=O)N(CCC(C)(C)N)c2ccccc21.O=c1ccc2c(C3CO3)cc(OCc3ccccc3)cc2[nH]1>>CCC1(CC)OC(=O)N(CCC(C)(C)NCC(O)c2cc(OCc3ccccc3)cc3[nH]c(=O)ccc23)c2ccccc21,,CC(C)O,CCOC(C)=O,,,val
US05550121,CC(O)=S.CN(CC[C@@H](O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>CC(=O)S[C@@H]1C[C@@H]([C@H](O)CCN(C)C(=O)OC(C)(C)C)N(C(=O)OC(C)(C)C)C1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120289526A1,COc1cc(Oc2ccc(NC(=O)[C@@H](C)N)cc2)ccc1C.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc(Oc2ccc(N3C(=O)N[C@H](C)C3=O)cc2)ccc1C,,ClCCl,,,,val
US06479531B1,C1COCCO1.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1ccc(N)cc1C(=O)OCc1ccccc1.Nc1cccc(C(=O)OCc2ccccc2)c1.O=CC1CCCCC1.O=CC1CCCCCC1>>Cc1ccc(NC(=O)c2nc(C3CCCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)cc1C(=O)O,,O,,,,val
US20040167119A1,C=O.Cl.NCCc1c[nH]c2ccc(O)cc12>>Cl.Oc1ccc2[nH]c3c(c2c1)CCNC3,,CCO,,CC(=O)O,,val
US05965589,COC(=O)C1CCc2cc(OCc3nc(-c4ccccc4)oc3C)ccc2C1O>>COC(=O)C1=Cc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2CC1,,ClCCl,,,,val
US05607960,CN1CCC(c2c[nH]c3ccc(C=CC4(O)CCCC4)cc23)CC1>>CN1CCC(c2c[nH]c3ccc(CCC4(O)CCCC4)cc23)CC1,,ClCCl,,,,val
US20060264432A1,CC(=O)n1ccnc1.N#Cc1c(N)nc(SCCN)c(C#N)c1-c1ccc(O)cc1>>CC(=O)NCCSc1nc(N)c(C#N)c(-c2ccc(O)cc2)c1C#N,,CN(C)C=O,,O,,val
US20050124623A1,N#CC(=C1CCNCC1)c1ccccn1.N#CCCl>>N#CCN1CCC(=C(C#N)c2ccccn2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20130217845A1,C=C(CC(C)C)C(=O)OCC>>C=C(CC(C)C)C(=O)O,,[K+],[OH-],Cl,,val
US20160130237A1,CC(C)N1CCN(c2ccc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])c2)CC1>>CC(C)N1CCN(c2ccc(N)c([N+](=O)[O-])c2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110275801A1,CCOC(=O)[C@@H]1CC[C@@H](c2nc(C)c(C)s2)CC1>>Cc1nc([C@@H]2CC[C@@H](C(=O)O)CC2)sc1C,,C1COCCO1,,[Na+].[OH-],,val
US20120142717A1,CCCBr.COc1ncc(Cc2c[nH]c(SCc3ccc(Oc4ccc(F)cc4)cc3)nc2=O)cn1>>CCCn1cc(Cc2cnc(OC)nc2)c(=O)nc1SCc1ccc(Oc2ccc(F)cc2)cc1,,ClCCCl,,CCN(C(C)C)C(C)C,,val
US20130029954A1,C=C(C)[C@@H]1CC[C@]2(CNCCc3ccc(C(=O)OC)cc3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(CNCCc3ccc(C(=O)O)cc3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1COCCO1,CO,O,[Li+].[OH-],val
US20090247591A1,CN(C)C1(c2ccccc2)CCC(N(C(=O)C(F)(F)F)C(Cc2c[nH]c3ccccc23)c2nnn[nH]2)CC1>>CN(C)C1(c2ccccc2)CCC(NC(Cc2c[nH]c3ccccc23)c2nnn[nH]2)CC1,,CO,,Cl,,val
US20090118263A1,CCCCOc1nc(N)c2nc(OC)n(Cc3ccc(OCCCN)cc3)c2n1.COC(=O)Cc1cccc(C=O)c1>>CCCCOc1nc(N)c2nc(OC)n(C(OCCCNCc3cccc(CC(=O)OC)c3)c3ccccc3)c2n1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20070275968A1,CS(=O)(=O)Nc1ccc(Br)c(F)c1.Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(B3OC(C)(C)C(C)(C)O3)c2)n1>>Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(-c3ccc(NS(C)(=O)=O)cc3F)c2)n1,,CCOC(C)=O,COCCOC,,,val
US20140057906A1,C[Si](C)(C)C#Cc1cc(C2(C(=O)[O-])CC2)ccc1N>>COC(=O)C1(c2ccc3[nH]ccc3c2)CC1,[Cu]I,,,CN(C)C=O,,val
US20120088748A1,CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Cl)c(F)c2)[C@H](CNC(=O)c2ncccc2N)C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Cl)c(F)c2)[C@H](CNC(=O)c2ncccc2NS(C)(=O)=O)C1,,CN(C)C=O,,O,[H-].[Na+],val
US20020128255A1,CCCN(CCC)C(=O)c1cc(C#N)cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CN(Cc2cccc(OC)c2)C(=O)OC(C)(C)C)c1.Cl>>CCCN(CCC)C(=O)c1cc(C#N)cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(OC)c2)c1.Cl,,CO,,ClCCl,,val
US20130045986A1,CC(C)OC(=O)Cl.Fc1cc(-c2ccc3oc(C4CCNCC4)nc3c2)ccc1-n1cnnn1>>CC(C)OC(=O)N1CCC(c2nc3cc(-c4ccc(-n5cnnn5)c(F)c4)ccc3o2)CC1,,ClCCl,O,Cc1ccccc1,O=C(O)C(F)(F)F,val
US20120295923A1,C=CC(=C)O[Si](C)(C)C.O=[N+]([O-])/C=C/c1ccc(C(F)(F)F)nc1>>O=C1CC[C@@H]([N+](=O)[O-])[C@H](c2ccc(C(F)(F)F)nc2)C1,,Cc1ccccc1,,CO,Cl,val
US20050143391A1,CC(C)(C)OC(=O)N1CCC(CN)CC1.CC(C)N=C=S>>CC(C)NC(=S)NCC1CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US20050020623A1,CC(C)(C)OC(=O)NCc1cccc(CNS(=O)(=O)c2cccc3cnccc23)c1>>NCc1cccc(CNS(=O)(=O)c2cccc3cnccc23)c1,,CO,,Cl,,val
US04904815,C=CC(C)(C)Br.CCOC(=O)C(C)P(=O)(OCC)OCC>>CCOC(=O)C(CC=C(C)C)P(=O)(OCC)OCC,,CCO,,[Na],,val
US20060116383A1,CCOC(=O)CC(c1ccccc1)n1cnc2cc(NC(=O)c3ccccc3[N+](=O)[O-])ccc21>>CCOC(=O)CC(c1ccccc1)n1cnc2cc(NC(=O)c3ccccc3N)ccc21,[Pd],CCO,O,O=C[O-].[NH4+],,val
US04767760,O=C(O)C(c1ccc(Cl)cc1)c1c(Cl)cc(-n2ncc(=O)[nH]c2=O)cc1Cl>>O=C1CNN(c2cc(Cl)c(C(C(=O)O)c3ccc(Cl)cc3)c(Cl)c2)C(=O)N1,[Zn],CC(=O)O,,,,val
US20030144139A1,CC(O)Cc1ccccc1F.CS(=O)(=O)Cl>>CC(Cc1ccccc1F)OS(C)(=O)=O,,ClCCl,,CCN(CC)CC,O,val
US04970213,CCOC(=O)c1cn(C)c2nc3c(F)c(N4CCNC(C)C4)c(F)cc3cc2c1=O>>CC1CN(c2c(F)cc3cc4c(=O)c(C(=O)O)cn(C)c4nc3c2F)CCN1,,CCO,,CC(=O)O,[K+].[OH-],val
US20080293712A1,COc1cc2ncc3c(N)nc(-c4cc(F)cc(CCCNC(=O)OC(C)(C)C)c4)cc3c2cc1OC>>COc1cc2ncc3c(N)nc(-c4cc(F)cc(CCCN)c4)cc3c2cc1OC,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040209875A1,CCOC(=O)C(C)(O)C1CC1c1cccc2c1OCO2>>CCOC(=O)C(=O)CC1CC1c1cccc2c1OCO2,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20090227625A1,COC(=O)C(C)(C)NC(=O)c1ccc2ccccc2c1OCCC(C)c1ccccc1>>CC(CCOc1c(C(=O)NC(C)(C)C(=O)O)ccc2ccccc12)c1ccccc1,,C1CCOC1,,[Na+].[OH-],,val
US20160052890A1,CC(C)(C)OC(=O)NCCBr.S=c1[nH]c2ccc(Cl)cc2[nH]1>>CC(C)(C)OC(=O)NCCSc1nc2cc(Cl)ccc2[nH]1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080242699A1,CNC1CCC(Oc2ccc3c(=O)n(Cc4ccc(OC)cc4)ccc3c2)CC1>>CN[C@@H]1CC[C@@H](Oc2ccc3c(=O)[nH]ccc3c2)CC1,,O=C(O)C(F)(F)F,,CO,,val
US20040167176A1,CC(C)(C)NS(=O)(=O)c1cccs1.CC(C)CI>>CC(C)Cc1ccc(S(=O)(=O)NC(C)(C)C)s1,,C1CCOC1,,[Li]CCCC,,val
US20040209921A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1C2CCC1CN(Cc1ccccc1)C2.[BH3-]C#N>>CC(C)(C)OC(=O)NC1C2CCC1CN(Cc1ccccc1)C2,,CO,O,CCN(CC)CC,,val
US20120028959A1,COC(=O)c1cc(C)cc2[nH]c(-c3c(F)c(F)c(-c4ccc(CO)cc4)c(F)c3F)nc12>>COC(=O)c1cc(C)cc2[nH]c(-c3c(F)c(F)c(-c4ccc(C=O)cc4)c(F)c3F)nc12,,C1CCOC1,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20060135578A1,CCn1cc(CO)cn1.O=S(Cl)Cl>>CCn1cc(CCl)cn1.Cl,,C1CCOC1,,,,val
US05902803,CCOC(=O)Cc1ccc2c(c1)Cc1c-2[nH]c(=O)c2nccn12.NCc1ccccc1>>O=C(Cc1ccc2c(c1)Cc1c-2[nH]c(=O)c2nccn12)NCc1ccccc1,,ClCCl,,,,val
US05801183,COc1ccc(-c2c(=O)[nH]c3cc(Cl)c(Cl)cc3[n+]2[O-])cc1>>O=c1[nH]c2cc(Cl)c(Cl)cc2[n+]([O-])c1-c1ccc(O)cc1,,ClCCl,,BrB(Br)Br,,val
US20160237045A1,CC(=O)Nc1ccccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1.Cl>>CC(=O)Nc1ccccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1.Cl,,C1CCOC1,C1COCCO1,,,val
US20110224188A1,CC(C)(C)OC(=O)N1CCC(N)(C(=O)NC2(c3ccccn3)CC2)CC1.C[C@@]1(Cc2ccc(C#N)cc2)C(=O)N(c2cc(Cl)cc(Cl)c2)c2ncc(C(=O)O)n21>>CC(C)(C)OC(=O)N1CCC(NC(=O)c2cnc3n2[C@](C)(Cc2ccc(C#N)cc2)C(=O)N3c2cc(Cl)cc(Cl)c2)(C(=O)NC2(c3ccccn3)CC2)CC1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040043987A1,Nc1ccccc1S(N)(=O)=O.O=C(Cl)CCCCl>>O=S1(=O)c2ccccc2NC2CCCN21,,O=S(=O)(O)O,,[Na+].[OH-],,val
US20070225267A1,CC(=O)N[C@@H](Cc1cc(F)cc(OCc2ccccc2)c1)[C@H](O)[C@H]1CO[C@@H](OCC(C)(C)C)[C@H](C)N1C(=O)OC(C)(C)C>>CC(=O)N[C@@H](Cc1cc(O)cc(F)c1)[C@H](O)[C@H]1CO[C@@H](OCC(C)(C)C)[C@H](C)N1C(=O)OC(C)(C)C,[Pd],CCO,,,,val
US20100016388A1,Cl.O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3ccccc3Cl)c2s1>>Cl.O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3ccccc3Cl)c2s1,,CO,,,,val
US20080319026A1,Cc1ccc(O)nc1.Ic1ccccc1>>Cc1ccc(=O)n(-c2ccccc2)c1,[Cu],,,O=C([O-])[O-].[K+].[K+],,val
US04027023,CCOC(=O)c1cc2cc(CC)ccc2nn1>>CCc1ccc2nnc(C(=O)O)cc2c1,,CCO,,,,val
US20090247567A1,CI.O=C(Nc1ccccc1Cl)c1cc2c(s1)-c1cnccc1OCC2>>CN(C(=O)c1cc2c(s1)-c1cnccc1OCC2)c1ccccc1Cl,,C1CCOC1,,O,[H-].[Na+],val
US20100261736A1,CCOC(=O)CCCCCOc1cccc2oc(-c3ccccc3)c(-c3ccc(OC)cc3)c12>>COc1ccc(-c2c(-c3ccccc3)oc3cccc(OCCCCCC(=O)O)c23)cc1,,CCO,,Cl,[Na+].[OH-],val
US20100105686A1,CC(C)[C@H](NC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccccc2)cc1)C(=O)OC(C)(C)C>>CC(C)[C@H](NC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccccc2)cc1)C(=O)O,,ClCCl,,,,val
US20060287291A1,ClI.O=S(=O)(Cl)c1ccc2c(c1)CCO2>>O=S(=O)(Cl)c1cc(I)c2c(c1)CCO2,,ClCCl,,CC#N,,val
US20080090801A1,Cc1nc(N)nc2c1cc(Br)c(=O)n2C1CCCC1.OB(O)c1cccc(O)c1>>Cc1nc(N)nc2c1cc(-c1cccc(O)c1)c(=O)n2C1CCCC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060079687A1,CCCNCc1cc(Sc2cccc(NS(=O)(=O)c3ccccc3)c2)ccc1N.N#CBr>>CCCN1Cc2cc(Sc3cccc(NS(=O)(=O)c4ccccc4)c3)ccc2N=C1N,,CCO,,,,val
US20020161040A1,CCOC(=O)Cl.Nc1ccc(O)cc1>>CCOC(=O)Nc1ccc(O)cc1,,ClCCl,,c1ccncc1,,val
US20100105667A1,CCOC(=O)c1ccc(-c2c(F)c(OC)cc(OC)c2F)c2nccnc12.COc1cc(OC)c(Cl)c(-c2ccc(C(=O)Nc3ccc(CN4CCN(C)CC4)cn3)c3nccnc23)c1Cl>>COc1cc(OC)c(F)c(-c2ccc(C(=O)Nc3ccc(CN4CCN(C)CC4)cn3)c3nccnc23)c1F,,CO,ClCCl,,,val
US20120040991A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2C[C@H]1COc1cnc(C(F)(F)F)cn1>>FC(F)(F)c1cnc(OC[C@@H]2C[C@H]3C[C@H]3CN2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US07618990B2,CC1(C)COC(=O)N1c1nc(OS(=O)(=O)C(F)(F)F)cs1.OB(O)c1ccc(C(F)(F)F)cc1>>CC1(C)COC(=O)N1c1nc(-c2ccc(C(F)(F)F)cc2)cs1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,CCN(CC)CC,,val
US04329347,CO.CSCCOc1ccc2c(c1)CCC(=O)N2>>CS(=O)CCOc1ccc2c(c1)CCC(=O)N2,,CO,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20090023710A1,O=[N+]([O-])c1ccccc1F.Sc1ccncc1>>O=[N+]([O-])c1ccccc1Sc1ccncc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130296436A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>O=S(=O)(OCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)F,,CCN(CC)CC,,CCOCC,Cl,val
US05344843,COC(=O)Cl.O=C(COc1ccc2ccccc2c1)Nc1ccc(C(=O)C(=O)O)cc1>>COC(=O)C(=O)c1ccc(NC(=O)COc2ccc3ccccc3c2)cc1,,ClCCl,O,CCN(CC)CC,,val
US20060160802A1,O=CN(CC1(C(=O)NNc2nccc(C(F)(F)F)n2)CCCCCC1)OCc1ccccc1>>O=CN(O)CC1(C(=O)NNc2nccc(C(F)(F)F)n2)CCCCCC1,[Pd],CO,,,,val
US20100105744A1,CC1(O)CCOc2cc(F)cc(F)c21.CSCc1cccc2cc[nH]c12>>CSCc1cccc2c(C3(C)CCOc4cc(F)cc(F)c43)c[nH]c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20010034351A1,O=S(Cl)Cl.O=c1[nH]cnc2cnc(Cl)cc12>>Clc1cc2c(Cl)ncnc2cn1,,Cc1ccccc1,,CN(C)C=O,,val
US20100324106A1,Brc1ccc(OCc2ccccc2)cc1.c1ccc(COc2cccc3[nH]ccc23)cc1>>c1ccc(COc2ccc(-n3ccc4c(OCc5ccccc5)cccc43)cc2)cc1,,C1COCCO1,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20060069149A1,CN(C)CCCCl.Oc1ccc2c(c1)Oc1ccccc1-c1ccsc1-2>>CN(C)CCCOc1ccc2c(c1)Oc1ccccc1-c1ccsc1-2,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US03952067,CCCC(=O)c1ccc(C2CCCCC2)cc1.O=[N+]([O-])O>>O=C(CC1CCCCC1[N+](=O)[O-])c1ccccc1,,O,,[Na+].[OH-],,val
US20040087577A1,Nn1c(=O)c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc21.O=C1CCCC1>>O=c1c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc2n1N=C1CCCC1,,CC(=O)N(C)C,,,,val
US20120053174A1,CO.O=C(O)c1cccc2c(O)nc(C(F)(F)c3ccc(F)cn3)nc12>>COC(=O)c1cccc2c(=O)[nH]c(C(F)(F)c3ccc(F)cn3)nc12,,CO,,CCOCC,Cl,val
US20160251339A1,COc1ccc(S(=O)(=O)n2ccc3ccc(Cl)cc32)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1>>COc1ccc(S(=O)(=O)n2ccc3ccc(Cl)cc32)cc1N1CCNCC1,,C1CCOC1,,[K+].[OH-],,val
US20060270724A1,COC(=O)C=C(c1ccc(OC2CCCCO2)cc1)c1ncco1>>COC(=O)CC(c1ccc(OC2CCCCO2)cc1)c1ncco1,[Pd],CO,,,,val
US20010027196A1,CCN.Nc1nc(OS(=O)(=O)C(F)(F)F)c([N+](=O)[O-])c(-c2ccco2)n1>>CCNc1nc(N)nc(-c2ccco2)c1[N+](=O)[O-],,COCCOC,,,,val
US20110136780A1,CC[C@H](NCc1ccnc2[nH]cc(C(=O)O)c12)C(=O)N1CCCC1>>CC[C@H](C(=O)N1CCCC1)N1Cc2ccnc3[nH]cc(c23)C1=O,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030207865A1,Cc1c(C#C[Si](C)(C)C)ccc(N=C2SCC3(CCCC3)N2CC(C)C)c1C>>C#Cc1ccc(N=C2SCC3(CCCC3)N2CC(C)C)c(C)c1C,,CO,ClCCl,[Na+].[OH-],,val
US20020072518A1,CCOC(=O)CC(C)=O.COc1ccc2c(ccc[n+]2[O-])c1>>CCOC(=O)Cc1ccc2cc(OC)ccc2n1,,CC(=O)OC(C)=O,,Cl,,val
US20130338081A1,COC(=O)c1ccc2c(c1)CN(C(=O)OC(C)(C)C)[C@H](C(=O)N[C@@H]1CCCc3ccccc31)C2>>COC(=O)c1ccc2c(c1)CN[C@H](C(=O)N[C@@H]1CCCc3ccccc31)C2,,ClCCl,,O=C(O)C(F)(F)F,,val
US05627200,COC(CBr)OC.Cc1c(C(=O)O)oc2ccc(O)cc12>>COC(COc1ccc2oc(C(=O)O)c(C)c2c1)OC,,C1COCCO1,CN(C)C=O,CCOC(C)=O,[H-].[Na+],val
US05843942,CCOC(=O)Cc1ccc(N)cc1.O=Cc1cc(Br)ccc1OCc1ccccc1>>CCOC(=O)Cc1ccc(NCc2cc(Br)ccc2OCc2ccccc2)cc1,,CCO,,CC(=O)O,[BH4-].[Na+],val
US05547950,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCN(c2ccc(N3C[C@@H](CN=[N+]=[N-])OC3=O)cc2F)CC1>>CC(=O)NC[C@H]1CN(c2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)c(F)c2)C(=O)O1,[Pd],CCOC(C)=O,,c1ccncc1,,val
US20030212225A1,C=CCC(C)(C)CO.CS(C)=O>>C=CCC(C)(C)COC,,CCOCC,,O,[H-].[Na+],val
US20040142850A1,CCOC(=O)Cl.NCc1ccccc1Cl>>CCOC(=O)NCc1ccccc1Cl,,c1ccncc1,,Cl,,val
US20090149425A1,CC(C)(C)c1cc(CO)on1.O=S(Cl)Cl>>CC(C)(C)c1cc(CCl)on1,,ClCCl,,,,val
US06903118B1,O=S(=O)(Cl)CCCCl.c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>O=S(=O)(CCCCl)N1CCN(C(c2ccccc2)c2ccccc2)CC1,,ClCCl,,ClC(Cl)Cl,,val
US20120316155A1,CSc1nccc(C=O)n1.O=C1CNC(=O)N1>>CSc1nccc(/C=C2\NC(=O)NC2=O)n1,,CCO,,C1CCNCC1,,val
US20060111375A1,COc1cc2nccc(Cl)c2cc1OC.COc1ccc(C(C)=O)c(O)c1>>COc1ccc(C(C)=O)c(Oc2ccnc3cc(OC)c(OC)cc23)c1,CN(C)c1ccncc1,Clc1ccccc1Cl,,,,val
US20090131439A1,Br.CNC(=O)NCCn1c(-c2ccc(N3CCOCC3)cc2)csc1=Nc1cccc(F)c1>>Br.CNC(=O)NCCn1c(-c2ccc(N3CCOCC3)cc2)csc1=Nc1cccc(F)c1,,ClC(Cl)Cl,,CC(=O)O,,val
US04230707,NC(=O)c1ccc2nc3cscc3c(=O)n2c1.O=S(Cl)Cl>>Cl.N#Cc1ccc2nc3cscc3c(=O)n2c1,,CN(C)C=O,,,,val
US20110201604A1,CNc1ccc(C(=O)NCC(=O)N(C)C)cc1[N+](=O)[O-]>>CNc1ccc(C(=O)NCC(=O)N(C)C)cc1N,[Pd],CO,,,,val
US20130197014A1,CN(C(=O)OC(C)(C)C)c1cccc(Nc2ncnc(N(Cc3ccccc3)Cc3ccccc3)c2N)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN(C(=O)OC(C)(C)C)c1cccc(-n2c(=O)[nH]c3c(N(Cc4ccccc4)Cc4ccccc4)ncnc32)c1,,ClCCl,,,,val
US05407922,CCCC[PH](=O)O.CCOC(=O)Cl>>CCCC[PH](=O)OCC,,ClCCl,,CCN(CC)CC,,val
US20120040020A1,Nc1ncc(C2=CCN(S(=O)(=O)CCN3C(=O)c4ccccc4C3=O)CC2)nc1-c1nc2ccccc2[nH]1>>NCCS(=O)(=O)N1CC=C(c2cnc(N)c(-c3nc4ccccc4[nH]3)n2)CC1,,CCO,CS(C)=O,NN,,val
US04332813,COC(=O)[C@H](CSc1ccc([N+](=O)[O-])cc1)NC(=O)OC(C)(C)C>>COC(=O)[C@@H](N)CSc1ccc([N+](=O)[O-])cc1,,COc1ccccc1,,O=C(O)C(F)(F)F,,val
US20040014802A1,CCCC(=O)Nc1nn(COCC[Si](C)(C)C)c2cc(B3OC(C)(C)C(C)(C)O3)ccc12.O=[N+]([O-])c1ccc(Br)cc1>>CCCC(=O)Nc1nn(COCC[Si](C)(C)C)c2cc(-c3ccc([N+](=O)[O-])cc3)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,O,O=C([O-])[O-].[Na+].[Na+],val
US05459029,CCCCCCCCCCBr.CN(C)C(=O)Cl.c1c[nH]cn1>>CCCCCCCCCC[n+]1ccn(C(=O)N(C)C)c1.[Br-],,CC(C)=O,,CCN(CC)CC,,val
US06410556B1,COc1ccc(CN2CCc3c(sc(N)c3C(=O)OC(C)(C)C)C2CN)cc1.O=S1(=O)N=C(Cl)c2ccccc21>>COc1ccc(CN2CCc3c(sc(N)c3C(=O)OC(C)(C)C)C2CNC2=NS(=O)(=O)c3ccccc32)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060041123A1,COc1cc(F)c2ncc(NC(=O)OC(C)(C)C)c(Br)c2c1>>COc1cc(F)c2ncc(N)c(Br)c2c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04468517,CN(C)CC1=NC(O)(CCl)CS1.ClCCCl>>CN(C)Cc1nc(CCl)cs1.Cl,,ClCCCl,,ClP(Cl)(Cl)(Cl)Cl,,val
US20050233988A1,CC(C)(O)C(C)(C)O.CC(C)OB(OC(C)C)OC(C)C.Fc1cccc(Br)n1>>CC1(C)OB(c2cccc(F)n2)OC1(C)C,,C1CCOC1,,[Li]CCCC,,val
US20130059853A1,CCI.COc1c(OC(F)F)ccc(-c2ccc3c(c2)COC3=O)c1O>>CCOc1c(-c2ccc3c(c2)COC3=O)ccc(OC(F)F)c1OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040097566A1,COc1ccc(Br)cc1C1(C#N)CCC(=O)CC1.OCCO>>COc1ccc(Br)cc1C1(C#N)CCC2(CC1)OCCO2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080153852A1,Clc1cc(Cl)ncn1.OC(c1ccccc1-c1ccco1)C(F)(F)F>>FC(F)(F)C(Oc1cc(Cl)ncn1)c1ccccc1-c1ccco1,,C1CCOC1,CCOC(C)=O,O,[H-].[Na+],val
US20130116247A1,COc1ccc2c(c1C=O)CCN(C(=O)OC(C)(C)C)C2.Cl>>Cl.O=Cc1c(O)ccc2c1CCNC2,,CCOC(C)=O,,,,val
US06702705B1,Cc1ccc(C(=O)Cl)cc1.O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1>>Cc1ccc(C(=O)OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](O)[C@@H]2O)cc1,,c1ccncc1,,,,val
US20150210671A1,Nc1cccnc1O.O=C(Cl)OCc1ccccc1>>O=C(Nc1cccnc1O)OCc1ccccc1,,ClCCl,,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20160185785A1,CC(C)(C)OC(=O)N1CCC(O)(Cn2cnc3c(cnn3-c3ccc(F)cc3)c2=O)CC1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=c1c2cnn(-c3ccc(F)cc3)c2ncn1CC1(O)CCNCC1,,ClCCl,,,,val
US20140080800A1,CO.O=C(NCC1CCNCC1)Nc1cc(-c2cccs2)ccc1[N+](=O)[O-]>>CN1CCC(CNC(=O)Nc2cc(-c3cccs3)ccc2N)CC1,[Pd],,,,,val
US05290477,CCCCC[C@H](COc1cnc(-c2ccc(OCc3ccccc3)cc2)nc1)OC1CCCCO1>>CCCCC[C@H](COc1cnc(-c2ccc(O)cc2)nc1)OC1CCCCO1,,CO,,C1CCOC1,,val
US20060135786A1,CC(C)(C)OC(=O)N[C@@](C)(CO)C(=O)O.O=[N+]([O-])c1ccc(OCCCCc2cccs2)cc1>>CC(C)(C)OC(=O)N[C@@](C)(CO)C(=O)Nc1ccc(OCCCCc2cccs2)cc1,,CCN(C(C)C)C(C)C,,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20150284408A1,CC(C)(C)OC(=O)N1CCC(NCc2ccc([N+](=O)[O-])cn2)CC1>>O=[N+]([O-])c1ccc(CNC2CCNCC2)nc1,,C1COCCO1,ClCCl,Cl,,val
US20110124634A1,COc1c(C)cnc(Cc2cn(S(=O)(=O)c3ccc(C)cc3)c3c(O)nc(N)nc23)c1C>>Oc1ncnc2cc[nH]c12,,CO,ClCCl,Cl,[K+].[OH-],val
US20060135517A1,CCC(=O)Cl.CSc1nccc(-c2c(-c3cccc(C)n3)nc3nc(N)ccn23)n1>>CCC(=O)Nc1ccn2c(-c3ccnc(SC)n3)c(-c3cccc(C)n3)nc2n1,,O,c1ccncc1,,,val
US20090076275A1,CC1=C(C(=O)O)NN(c2ccccc2)N1.CCn1[nH]c(=O)c2cc([N+](=O)[O-])ccc21>>CCn1[nH]c(=O)c2cc(NC(=O)c3nn(-c4ccccc4)nc3C)ccc21,[Pd],CCO,,CCN=C=NCCCN(C)C,,val
US20160002263A1,C=CCCC1(C)CCNCC1.CCOC(=O)c1cc2nc(C)c([C@H](OC(C)(C)C)C(=O)OCC)c(I)n2n1>>C=CCCC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OCC)c(C)nc3cc(C(=O)OCC)nn23)CC1,,CN1CCCC1=O,O,CCN(C(C)C)C(C)C,Cl,val
US05591828,NNC(=S)NNCc1ccccc1.O=C(CCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O.O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O>>NNC(=S)NN(Cc1ccccc1)C(=O)CCCN1C(=O)C=CC1=O.O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O,,CN(C)C=O,,,,val
US20150166578A1,CC(C)(C)CCNC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CC(C)(C)CCNC(=O)[C@@H]1C[C@H]2C[C@H]2N1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05641784,BrCc1ccccc1.CCCn1c(=O)c2[nH]c(C3CCC(=O)C3)nc2n(CCC)c1=O>>CCCn1c(=O)c2c(nc(C3CCC(=O)C3)n2Cc2ccccc2)n(CCC)c1=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20150344481A1,CC(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nc4ccc(N5CCOCC5)cn34)ccc2n1>>Nc1cn2nc(-c3c(-c4ccc(F)cc4)nc4ccc(N5CCOCC5)cn34)ccc2n1,,CO,,C1COCCO1,Cl,val
US20100004292A1,CC(C)(C)[Si](C)(C)OCCN(C#N)c1ccc(NC(=O)c2ccncc2NC(=O)c2ccc(Cl)cc2)cc1.CS(=O)(=O)O>>CS(=O)(=O)O.N=C1OCCN1c1ccc(NC(=O)c2ccncc2NC(=O)c2ccc(Cl)cc2)cc1,,CCOCC,,,,val
US06313162B1,CC(C)(C)c1cc(CO)c(C#C[Si](C)(C)C)c(C(C)(C)C)c1OCOCC[Si](C)(C)C>>C#CC(O)c1cc(C(C)(C)C)c(OCOCC[Si](C)(C)C)c(C(C)(C)C)c1,,O,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20080214549A1,CC(C)c1nn(Cc2ccc(Br)cc2F)c(=O)c(C(=O)NCC(=O)O)c1O.CSc1ccc(B(O)O)cc1>>CSc1ccc(-c2ccc(Cn3nc(C(C)C)c(O)c(C(=O)NCC(=O)O)c3=O)c(F)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20070208020A1,CI.CSc1nc(N)nc(S)c1C#N>>CSc1nc(N)nc(SC)c1C#N,,CC(C)=O,,,,val
US06420418B1,CCOC(=O)C1(c2ccccc2)CCCO1>>O=C(O)C1(c2ccccc2)CCCO1,,CO,,[Na+].[OH-],,val
US06080752,C=CC(N)=O.COc1cccc2c1CCC(N1CCCC1)=C2>>COc1cccc2c1CCC1=C2CCC(=O)N1,,O,,,,val
US20150252044A1,CC1(C)OB(c2ccc(CN)cc2)OC1(C)C.CCCCCCC(=O)O>>CCCCCCC(=O)NCc1ccc(B2OC(C)(C)C(C)(C)O2)cc1,CN(C)C=O,ClCCl,O,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US05393790,CSc1ccc(C(C)=O)cc1.C[Si](C)(C)Cl>>C=C(O[Si](C)(C)C)c1ccc(SC)cc1,,CC#N,,CCN(CC)CC,[I-].[Na+],val
US06010981,COC(=O)c1ccc(S(C)(=O)=O)c(-c2ccccc2)c1Cl>>CS(=O)(=O)c1ccc(C(=O)O)c(Cl)c1-c1ccccc1,,CO,,[Na+].[OH-],,val
US04474692,O=C(CNC1Cc2ccccc2C1)OCc1ccccc1.O=C(Cl)CCl>>O=C(CN(C(=O)CCl)C1Cc2ccccc2C1)OCc1ccccc1,,CCOC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130172330A1,CC(C)(C)OC(=O)NCCCCNC1CCCc2cccnc21.O=Cc1nccc2c1[nH]c1ccccc12>>CC(C)(C)OC(=O)NCCCCN(Cc1nccc2c1[nH]c1ccccc12)C1CCCc2cccnc21,CC(=O)O,ClCCCl,,O=C([O-])O.[Na+],,val
US20070232583A1,COC(OC)C(C)NC(=S)Nc1cccc(Br)c1>>Cc1cn(-c2cccc(Br)c2)c(S)n1,,Cl,O,,,val
US20040209921A1,CC(C)(C)OC(=O)N1CCC(N)CC1.Cc1cc(Cl)cnc1C=O>>Cc1cc(Cl)cnc1CNC1CCN(C(=O)OC(C)(C)C)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20080242661A1,CN1N=C(Br)C2N=C(Cl)N=C(Cl)C21.[OH-]>>CN1N=C(Br)C2N=C(Cl)N=C(O)C21,,C1CCOC1,,Cl,,val
US20040157886A1,CCOC(=O)C(=O)N1CCC(Oc2ccc(F)cc2)CC1>>O=C(O)C(=O)N1CCC(Oc2ccc(F)cc2)CC1,,CCO,O,,,val
US20150031733A1,COS(=O)(=O)OC.Cc1c(I)cccc1-n1nn[nH]c1=O>>Cc1c(I)cccc1-n1nnn(C)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20060281743A1,COc1ccc2c(=O)n(C)c(CCN)c(-c3ccccc3)c2c1.O=C(Cl)CCCCl>>COc1ccc2c(=O)n(C)c(CCN3CCCC3=O)c(-c3ccccc3)c2c1,,ClCCl,,CCN(CC)CC,Cl,val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.COc1ccc(N)cc1>>COc1ccc(Nc2nc3ccc(OC)cc3c3c[nH]nc23)cc1,C1COCCO1,CO,,Cl,,val
US20150191434A1,CCOC(=O)C1CC=C(c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cccc(F)c23)CC1>>CCOC(=O)C1CCC(c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cccc(F)c23)CC1,[Pd],CCOC(C)=O,,,,val
US05556941,COc1cc(C)c(S(=O)(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc2ccc(C(=N)N)cc2)C(=O)N2CCCCC2)c(C)c1C.Cl.N[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O>>COc1cc(C)c(S(=O)(=O)N[C@@H](CC(=O)N[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)C(=O)N[C@H](Cc2ccc(C(=N)N)cc2)C(=O)N2CCCCC2)c(C)c1C.Cl,,CN(C)C=O,ClCCl,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20050026916A1,CC(C)(C)OC(=O)N1C(NCc2cccc(F)c2)=N[C@@H](c2ccccc2)[C@H]1c1ccccc1.Cl>>Cl.Fc1cccc(CNC2=N[C@@H](c3ccccc3)[C@@H](c3ccccc3)N2)c1,,CCOC(C)=O,,,,val
US20120059000A1,COc1ncnc(N)c1C(F)(F)F>>Nc1ncnc(O)c1C(F)(F)F,,C1COCCO1,,Cl,,val
US20050261342A1,COc1ccc(OC(F)(F)F)cc1C(=O)O>>O=C(O)c1cc(OC(F)(F)F)ccc1O,,CS(C)=O,,,,val
US04729784,CCCN1C(=O)COc2ccc(N3C(=O)C(C)=C(C)C3=O)cc21>>CCCN1C(=O)COc2ccc(N3C(=O)C(C)=C(C)C3O)cc21,CC(=O)O,CO,,[BH4-].[Na+],,val
US20040171881A1,CCCCn1ncc2ccc(C(=O)OC)cc21>>CCCCn1ncc2ccc(C(=O)O)cc21,,CO,,Cl,[Na+].[OH-],val
US05189054,CCOC(=O)c1c(NCCC(=O)c2ccccc2Cc2ccccc2)c2c(Cl)cc(Cl)cc2n1C(=O)OC(C)(C)C>>CCOC(=O)c1[nH]c2cc(Cl)cc(Cl)c2c1NCCC(=O)c1ccccc1Cc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140350006A1,CCOC(=O)c1cc(B(O)O)ccc1F.FC(F)c1cc(Br)nc2[nH]nc(-c3ccccc3)c12>>O=C(O)c1cc(-c2cc(C(F)F)c3c(-c4ccccc4)n[nH]c3n2)ccc1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090264444A1,CCOC(=O)c1sc(N2CCN(CC(=O)NCc3ccc(F)cc3)C2=O)nc1C>>Cc1nc(N2CCN(CC(=O)NCc3ccc(F)cc3)C2=O)sc1C(=O)O,,CCO,O,Cl,[Na+].[OH-],val
US05338531,Cl[Pd]Cl.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]>>O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+].[Pd],,O,,,,val
US20050014805A1,CCC(Br)C(=O)OC.COc1ccc2c(c1)CCC2=O>>CCC(C(=O)OC)C1=CCc2cc(OC)ccc21,[Zn],C1CCOC1,,Cl,,val
US04755594,NCC1(c2cccs2)CC1.O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(NCC4(c5ccccc5)CC4)ncnc32)[C@@H]1O>>O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(NCC4(c5cccs5)CC4)ncnc32)[C@@H]1O,,O=CO,,CCN(CC)CC,,val
US20080167453A1,CN(CC[N+](C)(C)C)c1ccc([N+](=O)[O-])cc1.COS(=O)(=O)[O-]>>CN(CC[N+](C)(C)C)c1ccc(N)cc1.COS(=O)(=O)[O-],[Pd],O,,[H][H],,val
US20110021496A1,CC(C)(C)OC(=O)N1C2CCC1CN(C(=O)C(F)(F)F)C2.O=C(O)C(F)(F)F>>O=C(N1CC2CCC(C1)N2)C(F)(F)F.O=C(O)C(F)(F)F,,ClCCl,,,,val
US05155122,CC(C)(C)c1cc(-c2nnc(S(C)(=O)=O)s2)cc(C(C)(C)C)c1O.NCCO>>CC(C)(C)c1cc(-c2nnc(NCCO)s2)cc(C(C)(C)C)c1O,,CC(C)O,,,,val
US20130190316A1,COC(=O)CCn1ccc(-c2ncccc2CO)n1.O=S(Cl)Cl>>COC(=O)CCn1ccc(-c2ncccc2CCl)n1.Cl,,ClCCl,,,,val
US20100197683A1,CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCNCC2)c2ncnn12.OCCBr>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCN(CCO)CC2)c2ncnn12,,O,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20050256170A1,CC(=O)Nc1cccc(O)c1.N#CCBr>>CC(=O)Nc1cccc(OCC#N)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US07217717B2,C=CCc1c(OC)c(OC)cc2ncnc(Nc3cccc(Br)c3)c12.II>>COc1cc2ncnc3c2c(c1OC)CC(CI)N3c1cccc(Br)c1,,ClC(Cl)Cl,ClCCl,,,val
US20080227783A1,Fc1ccc(Nc2nccs2)cc1.O=C1CCC(=O)N1Cl>>Fc1ccc(Nc2ncc(Cl)s2)cc1,,C1CCOC1,,,,val
US20120295966A1,CC(=O)Cl.CCOC(=O)Cc1ccccc1>>CCOC(=O)Cc1ccc(C(C)=O)cc1,,S=C=S,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20090023731A1,NC1CCCC(O)C1.O=C=NC12CC3CC(CC(C3)C1)C2>>O=C(Nc1ccccc1)NC1CCCC(O)C1,,CN(C)C=O,,,,val
US20120208799A1,COc1cccc(C=NO)c1F>>COc1cccc(CN)c1F,[Pd],CCO,,,,val
US05643878,C(=NC1CCCCC1)=NC1CCCCC1.C1COCCN1.O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)OCc1ccccc1>>O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)OCc1ccccc1.[NH-]N1CCOCC1,,ClCCl,,On1nnc2ccccc21,,val
US20130045942A1,COc1ccc([C@@H](C)N)cc1.OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O>>COc1ccc([C@@H](C)Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1,,CCCO,,,,val
US20140080798A1,C=O.NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CCNCC3)nc2)ncc1C(F)(F)F>>CN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cn2)CC1,,CO,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20100160327A1,CC(C)(C)OC(=O)Nc1ccccc1N.CCN=C=NCCCN(C)C.CN(C)C=O.O=C(O)c1ccc(C(C(=O)Nc2ccccc2)C(=O)Nc2ccccc2)cc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(C(C(=O)Nc2ccccc2)C(=O)Nc2ccccc2)cc1.O=C(O)O,,CN(C)C=O,,,,val
US20040224997A1,CC(C)(C)OC(=O)CBr.COC(=O)C1CCOCC1>>COC(=O)C1(CC(=O)OC(C)(C)C)CCOCC1,,C1CCOC1,O,CC(C)NC(C)C,[Li]CCCC,val
US20140206680A1,O=C(O)c1cc2c(F)cccc2s1>>Fc1cccc2sccc12,,CC(=O)N(C)C,,C1CCC2=NCCCN2CC1,O,val
US04124590,CC(=O)N1CCCC(O)C1.ClCc1ccccc1>>CC(=O)N1CCCC(OCc2ccccc2)C1,,O,,CN(C)C=O,[H-].[Na+],val
US20080051458A1,CC(C)C(OC(=O)ON1C(=O)CCC1=O)OC(=O)C1CCCCC1.NC1(C(=O)O)CC1>>CC(C)C(OC(=O)NC1(C(=O)O)CC1)OC(=O)C1CCCCC1,,CC#N,O,,,val
US05262540,COC(=O)COc1ccc(C=O)cc1.COP(=O)(Cc1nc(-c2ccccc2)c(-c2ccccc2)o1)OC>>COC(=O)COc1ccc(C=Cc2nc(-c3ccccc3)c(-c3ccccc3)o2)cc1,,CO,O,[Na],,val
US20130183771A1,CCOC(=O)c1cc(I)cc(C(=O)OCC)n1>>OCc1cc(I)cc(CO)n1,,CCO,,[BH4-].[Na+],,val
US20110263559A1,CC(C)(C)OC(=O)N1CCC(N2CC(O)C2)CC1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCC(N2CC(OS(C)(=O)=O)C2)CC1,,ClCCl,,,,val
US20130059853A1,CC1(CBr)COC1.CCOc1ccc(-c2cccc3c2CCC3=O)c(O)c1OC>>CCOc1ccc(-c2cccc3c2CCC3=O)c(OCC2(C)COC2)c1OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04474692,CCOC(=O)C(=O)CCc1ccccc1.C[C@H](N)C(=O)N(CCC(=O)O)C1Cc2ccccc2C1.Cl>>CCOC(=O)C(CCc1ccccc1)N[C@@H](C)C(=O)N(CCC(=O)O)C1Cc2ccccc2C1.Cl,,CCO,O,[BH3-]C#N.[Na+],,val
US20150376130A1,CCCCNc1ccc(F)cc1C(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.ClCCl>>C#CC(C)(CC)NC(=O)c1cc(F)ccc1NCCCC,,ClCCl,,On1nnc2ccccc21,,val
US05707991,COC(=O)Cc1cccc(NC(=O)NCC(=O)N2C(C(=O)NCC(C)C)CC(C(=O)OC)C2c2ccccc2F)c1>>CC(C)CNC(=O)C1CC(C(=O)O)C(c2ccccc2F)N1C(=O)CNC(=O)Nc1cccc(CC(=O)O)c1,,CO,O,[K+].[OH-],,val
US04444584,CCOC(=O)C(C)Oc1ccc(Oc2ccc3cc(Cl)ccc3n2)cc1>>CC(Oc1ccc(Oc2ccc3cc(Cl)ccc3n2)cc1)C(=O)O,,CO,,Cl,[K+].[OH-],val
US06046201,CC(C)(C)OC(=O)NCCCCCCCCCCCCO.Cl>>Cl.NCCCCCCCCCCCCO,,CO,,,,val
US20050085465A1,COc1cc2c(=O)[nH]cnc2cc1OCc1ccccc1>>COc1cc2c(=O)[nH]cnc2cc1O,[Pd],CN(C)C=O,,O=C[O-].[NH4+],,val
US20140200207A1,C[Si](C)(C)CCOCn1cc(I)c2c(NC3CCCC3)nc(Cl)nc21.OB(O)c1ccc(O)cc1>>C[Si](C)(C)CCOCn1cc(-c2ccc(O)cc2)c2c(NC3CCCC3)nc(Cl)nc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20090192138A1,CI.ClCCl.Cn1c(=O)[nH]c(=O)c2c1c(C#N)c(N1CCN(C(=O)OC(C)(C)C)CC1)n2Cc1ccccc1>>Cl.Cn1c(=O)c2c(c(C#N)c(N3CCNCC3)n2Cc2ccccc2)n(C)c1=O,,CN(C)C=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US04786638,CCOC(=N)c1ccccc1.O=C(Cl)c1cccc2c(Br)cccc12>>CCOC(=NC(=O)c1cccc2c(Br)cccc12)c1ccccc1,,Cc1ccccc1,,CCN(CC)CC,Cl,val
US20140275084A1,COC(=O)c1ccnc(-c2c[nH]cn2)c1.Fc1ccccc1CCBr>>O=C(O)c1ccnc(-c2cn(CCc3ccccc3F)cn2)c1,,CO,,[Na+].[OH-],,val
US05428041,NC(c1cc(-c2ccc(F)cc2)c(-c2ccc(F)cc2)[nH]1)(C(F)(F)F)C(F)(F)F.O=C(OO)c1cccc(Cl)c1>>O=C(C=C1NC(c2ccc(F)cc2)=NC1(C(F)(F)F)C(F)(F)F)c1ccc(F)cc1,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20060035977A1,CC(C)(C)OC(=O)NCC(O)CNC(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC(CNC(=O)OC(C)(C)C)CNC(=O)OC(C)(C)C)cc1,,ClCCl,O,CCN(CC)CC,,val
US20160068515A1,C[C@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(Br)cc1C#N.Cl>>C[C@H]1CNCCN1c1ncc(Br)cc1C#N.Cl,,CCOC(C)=O,,,,val
US20160159718A1,COc1cc(C)cc(-c2cc(C(C)C)c(C)cc2O)c1O.ClP(Cl)Oc1c2ccccc2cc2ccccc12>>COc1cc(C)cc2c1op(Oc1c3ccccc3cc3ccccc13)oc1cc(C)c(C(C)C)cc12,,Cc1ccccc1,,CCN(CC)CC,,val
US05981533,CC(=O)Nc1ccc(CNc2n[nH]c3ncnc(Nc4cccc(Cl)c4)c23)cc1>>Nc1ccc(CNc2n[nH]c3ncnc(Nc4cccc(Cl)c4)c23)cc1,,O,,[Na+].[OH-],,val
US20080182870A1,CCO.NS(=O)(=O)c1ccc(CNc2nc(-n3cnnc3)c3nc(-c4ccc(F)cc4)ccc3n2)cc1>>CCOc1nc(NCc2ccc(S(N)(=O)=O)cc2)nc2ccc(-c3ccc(F)cc3)nc12,,C1CCOC1,CN(C)C=O,C,C[O-].[Na+],val
US05189211,NCCSc1ccc(CCC(=O)O)cc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=C(O)CCc1ccc(SCCNS(=O)(=O)c2ccc(Cl)cc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20060241296A1,OB(O)c1ccc(C(F)(F)F)cc1CN1CCCCC1.OC1CCc2cccc(Nc3cc(Cl)ncn3)c2C1>>OC1CCc2cccc(Nc3cc(-c4ccc(C(F)(F)F)cc4CN4CCCCC4)ncn3)c2C1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,O,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US05416211,COC(=O)c1ccc(CCC(Br)C=O)cc1.Nc1cc(O)nc(N)n1>>COC(=O)c1ccc(CCc2c[nH]c3nc(N)[nH]c(=O)c23)cc1,,CO,,O,CC(=O)[O-].[Na+],val
US20160221997A1,CCOC(=O)c1ccc2c(c1)OCCCNC2.NO>>O=C(NO)c1ccc2c(c1)OCCCNC2,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20060019906A1,CCOC(=O)c1cn(CCO[Si](C)(C)C(C)(C)C)c2c(F)cc(Cc3cccc(Cl)c3Cl)cc2c1=O>>CCOC(=O)c1cn(CCO)c2c(F)cc(Cc3cccc(Cl)c3Cl)cc2c1=O,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US03952001,C=CCN(CC=C)S(=O)(=O)c1nc[nH]n1.CCN(CC)C(=O)Cl>>C=CCN(CC=C)S(=O)(=O)c1ncn(C(=O)N(CC)CC)n1,,C1CCOC1,,CCN(CC)CC,,val
US20090042856A1,CCOC(=O)CCN=C=S.NNCCO>>CCOC(=O)CCNC(=S)N(N)CCO,,CCO,,,,val
US20100094000A1,CC1(C)OB(c2ccc3c(c2)NC(=O)CO3)OC1(C)C.Cc1nn(Cc2ccoc2C)c(-c2ccc(F)cc2)c1Br>>Cc1nn(Cc2ccoc2C)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2,,C1CCOC1,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20090275570A1,CC(C)(C)OC(=O)N1CCC[C@H](Nc2ncc(C#N)c3cc(-c4cccc(F)c4)sc23)C1>>NC(=O)c1cnc(N[C@H]2CCCNC2)c2sc(-c3cccc(F)c3)cc12,,O,,[Na+].[OH-],,val
US20100305096A1,CS(=O)(=O)CCN1CCNCC1.Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1>>Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCN(CCS(C)(=O)=O)CC3)n(C)c2n1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090186879A1,O=[N+]([O-])c1cccc([N+](=O)[O-])c1NCCO>>Nc1cccc(N)c1NCCO,[Pd],C1CCOC1,,,,val
US05760032,CCOC(=O)CC1N=C(c2ccccc2Cl)c2cc(CC)sc2-n2c(C)nnc21.O=C(Cl)c1ccc(Cl)c(Cl)c1.O=C([O-])O>>CCOC(=O)CC(NC(=O)c1ccc(Cl)c(Cl)c1)c1nnc(C)n1-c1sc(CC)cc1C(=O)c1ccccc1Cl,,ClC(Cl)Cl,,Cl,,val
US04115380,COc1cc([N+](=O)[O-])c(C)cc1N>>COc1cc(N)c(C)cc1N,[Ni],O,,NN,,val
US05576324,CS(=O)(=O)OCC1Cc2c(ccc3[nH]c(=O)ccc23)O1.[N-]=[N+]=[N-]>>[N-]=[N+]=NCC1Cc2c(ccc3[nH]c(=O)ccc23)O1,,CN(C)C=O,,O,,val
US20140288069A1,COc1nccc2oc(-c3cnc4ccc(Cl)nn34)cc12.NCC(O)C1CC1>>COc1nccc2oc(-c3cnc4ccc(NCC(O)C5CC5)nn34)cc12,,CCCCO,,,,val
US05428171,COC(=O)CCSC(SCCC(=O)OC)c1cccc(O)c1.Clc1ccc2ccc(CBr)nc2c1>>COC(=O)CCSC(SCCC(=O)OC)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1,,CCC(C)=O,,CCOCC,O=C([O-])[O-].[K+].[K+],val
US20150329538A1,CCN.Nc1c(C(=O)O)ccc(F)c1Br>>CCNC(=O)c1ccc(F)c(Br)c1N,,CN(C)C=O,ClCCl,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20020077493A1,COc1cc(S(=O)(=O)[O-])ccc1OS(=O)(=O)c1ccc(C)cc1.c1ccc([S+](c2ccccc2)c2ccccc2)cc1>>COc1cc(S(=O)(=O)[O-])ccc1OS(=O)(=O)c1ccc(C)cc1.c1ccc([S+](c2ccccc2)c2ccccc2)cc1,,ClCCl,,[Cl-].[Na+],,val
US20120184508A1,CC(C)(C)OC(=O)NC1CCC(Nc2ncc3c(-c4ccnc(NCc5ccccc5)n4)n[nH]c3n2)CC1>>NC1CCC(Nc2ncc3c(-c4ccnc(NCc5ccccc5)n4)n[nH]c3n2)CC1,,CO,Cl,,,val
US20150376130A1,COC(=O)c1cccnc1Nc1ccccc1F>>O=C(O)c1cccnc1Nc1ccccc1F,,CO,O,[K+].[OH-],,val
US20120101134A1,CC(C)Oc1ccc(-c2nnc(Br)s2)cc1Cl.CCc1c(C=O)cccc1B1OC(C)(C)C(C)(C)O1>>CCc1c(C=O)cccc1-c1nnc(-c2ccc(OC(C)C)c(Cl)c2)s1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20160207930A1,Cc1cccc([C@@H](OS(C)(=O)=O)[C@@H]2CCC(=O)N2CCNC(=O)OC(C)(C)C)c1C>>Cc1cccc([C@H]2[C@@H]3CCC(=O)N3CCN2C(=O)OC(C)(C)C)c1C,,C1CCOC1,,[H-].[Na+],,val
US20150218165A1,C#CC[C@@H]1COC(=O)N1.C=CCBr>>C#CC[C@@H]1COC(=O)N1CC=C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04636501,CC(C)COCCOc1ccc(OCC2CO2)cc1.CN(C)C(=O)NCCN>>CC(C)COCCOc1ccc(OCC(O)CNCCNC(=O)N(C)C)cc1,,CC(C)O,,,,val
US20160207948A1,CCOP(=O)(OCC)c1cnn(CC(NC(=O)OC(C)(C)C)C(=O)OC)c1>>CCOP(=O)(OCC)c1cnn(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)c1,,C1CCOC1,,O,[Li+].[OH-],val
US20080265746A1,Brc1ccccc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1>>c1ccc(-c2cc(-c3ccccc3)c3ccc4c(-c5ccccc5)ccnc4c3n2)cc1,,C1CCOC1,,O,[Li]CCCC,val
US20110028481A1,Brc1nc2ccccc2s1.O=C(O)[C@@H]1CCCN1>>O=C(O)[C@@H]1CCCN1c1nc2ccccc2s1,I[Cu]I,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110294793A1,Fc1ccc(Oc2cccc(CNCCCCc3ccccc3)c2)cc1.O=S(=O)(Cl)c1cc(Cl)cc(Cl)c1O>>O=S(=O)(c1cc(Cl)cc(Cl)c1O)N(CCCCc1ccccc1)Cc1cccc(Oc2ccc(F)cc2)c1,,ClCCl,,CCN(CC)CC,,val
US20040167155A1,COc1ccc(S(=O)(=O)NC(C)c2ccccc2-c2ccc(Cl)cc2F)cc1>>COc1ccc(S(=O)(=O)N2c3cc(Cl)ccc3-c3ccccc3C2C)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140235640A1,CCOc1cc(C=O)cc([N+](=O)[O-])c1O.NC(N)=O.O=C(Cc1ccccc1)c1ccco1>>CCOc1cc(C2NC(=O)NC(c3ccco3)=C2c2ccccc2)cc([N+](=O)[O-])c1O,,CCO,CCOC(C)=O,Cl,,val
US20080015203A1,CCOC(=O)c1ccc(Oc2cc(O[C@@H](C)CO)cc(C(=O)Nc3cc[nH]n3)c2)cc1>>C[C@@H](CO)Oc1cc(Oc2ccc(C(=O)O)cc2)cc(C(=O)Nc2cc[nH]n2)c1,,C1CCOC1,O,[Na+].[OH-],,val
US04235774,CS(=O)(=O)N1CCN(C(=O)Cl)C1=O.NC(C(=O)O)c1csc(NC(=O)OCc2ccccc2)n1>>CS(=O)(=O)N1CCN(C(=O)NC(C(=O)O)c2csc(NC(=O)OCc3ccccc3)n2)C1=O,,C1CCOC1,O,,,val
US20140163066A1,CCOC(CCNC(=O)OC(C)(C)C)OCC.COc1cccc(CBr)c1>>COc1cccc(CNCCC2OCCO2)c1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US04816458,CCOCCC(C(=O)O)C(=O)O.Cn1c(=O)c2[nH]c(NCc3ccccc3)nc2n(C)c1=O>>CCOCCc1c(O)n2c3c(=O)n(C)c(=O)n(C)c3nc2n(Cc2ccccc2)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US20150225397A1,CO.COc1ccccc1-c1nc(Cl)c2c(n1)[C@@]1(c3ccccc3)CCC3(OCCO3)[C@@H](C)[C@@H]1CC2>>COc1ccccc1-c1nc(OC)c2c(n1)[C@@]1(c3ccccc3)CCC3(OCCO3)[C@@H](C)[C@@H]1CC2,,C1CCOC1,CO,C[O-].[Na+],,val
US05047411,CO.Cc1c(CCc2ccc3nc(N)oc3c2)nc2cc(CCl)ccn12>>COCc1ccn2c(C)c(CCc3ccc4nc(N)oc4c3)nc2c1,,CO,,C[O-].[Na+],,val
US20120270875A1,Cc1nc(NCCCc2cccc3[nH]ncc23)nc(C)c1C(=O)N[C@@H](CNC(=O)c1cccs1)C(=O)O.IC1CCCC1>>Cc1nc(NCCCc2cccc3[nH]ncc23)nc(C)c1C(=O)N[C@@H](CNC(=O)c1cccs1)C(=O)OC1CCCC1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20070004736A1,BrCCBr.O=S(O)c1ccc2cc(Cl)ccc2c1>>C=CS(=O)(=O)c1ccc2cc(Cl)ccc2c1,,CN(C)C=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US04917826,C[C@]12CCCC[C@@H]1CC[C@H]1[C@@H]3CC[C@H](N)[C@@]3(C)CC[C@@H]12.O=Cc1ccc(Cl)cc1>>C[C@]12CCCC[C@@H]1CC[C@H]1[C@@H]3CC[C@H](NCc4ccc(Cl)cc4)[C@@]3(C)CC[C@@H]12,,C1CCOC1,CO,CC(=O)O,[BH3-]C#N.[Na+],val
US20030119807A1,COC(=O)c1nc([C@H](CCCC2CCCCC2)CC(=O)NOCc2ccccc2)oc1C>>Cc1oc([C@H](CCCC2CCCCC2)CC(=O)NOCc2ccccc2)nc1C(=O)O,,C1COCCO1,,[Na+].[OH-],,val
US20150158851A1,CC(C)(C)[Si](C)(C)Cl.CC1(O)CCC2(CC1)OCCO2>>CC1(O[Si](C)(C)C(C)(C)C)CCC2(CC1)OCCO2,,C1CCOC1,O,CN(C)C=O,c1c[nH]cn1,val
US20030212290A1,C1CN2CCN1CC2.C=C(C#N)CC(C)C.CC(=O)[O-]>>CCOC(=O)CC(C#N)=CC(C)C,[Pd],,,,,val
US20090048291A1,CC(CO)N1CCC(CC(=O)Nc2ccc(S(C)(=O)=O)cc2)CC1.O=S(Cl)Cl>>CC(CCl)N1CCC(CC(=O)Nc2ccc(S(C)(=O)=O)cc2)CC1.Cl,,Cc1ccccc1,,,,val
US20090137580A1,Cn1ccc2ncnc(Cl)c21.Nc1ccc(O)cc1Cl>>Cn1ccc2ncnc(Oc3ccc(N)c(Cl)c3)c21,,O,,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US20100190831A1,CCOC(=O)CC1CCCc2cc(OC)ccc21>>CCOC(=O)CC1CCCc2cc(O)ccc21,,ClCCl,,BrB(Br)Br,,val
US20040029888A1,Clc1ncccc1OCCOC1CCCCO1.OCC1CCCNC1>>OCCOc1cccnc1OCC1CCCNC1,,Cc1ccccc1,,CC(C)(C)O,CC(C)(C)[O-].[K+],val
US06379590B1,C[O-].O=[N+]([O-])c1ccc2c(c1)C(C1OCCO1)c1cc([N+](=O)[O-])ccc1-2>>COc1ccc2c(c1)C(C1OCCO1)c1cc([N+](=O)[O-])ccc1-2,,O,,CN(C)C=O,,val
US20040063775A1,CCOC(=O)Cc1cn(Cc2ccccc2)nc1O.COc1cc(CCl)ccc1OCc1nc(-c2ccccc2)oc1C>>CCOC(=O)Cc1cn(Cc2ccccc2)nc1OCc1ccc(OCc2nc(-c3ccccc3)oc2C)c(OC)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04542148,CI.O=C1Nc2ccc(Cl)cc2C1c1ccccc1>>CC1(c2ccccc2)C(=O)Nc2ccc(Cl)cc21,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040259888A1,CN1CCN(c2ncnc3oc(-c4ccc([N+](=O)[O-])cc4)c(-c4ccc(F)cc4)c23)CC1>>CN1CCN(c2ncnc3oc(-c4ccc(N)cc4)c(-c4ccc(F)cc4)c23)CC1,[Pd],C1CCOC1,CO,[H][H],,val
US20110071126A1,COC(=O)CC(=O)CC(=O)OC>>COC(=O)CC(O)CC(=O)OC,,CO,,[BH4-].[Na+],,val
US20140221333A1,COC(=O)C1CCCN(c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1>>Nc1nccn2c(N3CCCC(C(=O)O)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12,,C1CCOC1,O,[Li+].[OH-],,val
US20090270394A1,CC(C)(C)OC(=O)NC1(C(=O)O)CCCCC1.CO>>COC(=O)C1(NC(=O)OC(C)(C)C)CCCCC1,,ClCCl,,CC(=O)O,,val
US20070259910A1,CN(C)c1ccc(F)c(N)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN(C)c1ccc(F)c(N=C=O)c1,,ClCCl,,c1ccncc1,,val
US20150329542A1,CCCI.CS(=O)(=O)Nc1ccccc1C#N>>CCCN(c1ccccc1C#N)S(C)(=O)=O,,CN1CCCC1=O,,[H-].[Na+],,val
US20130317000A1,CS(=O)(=O)NC(=O)c1cc(F)c(F)cc1F.OCCC1CC1>>CS(=O)(=O)NC(=O)c1cc(F)c(OCCC2CC2)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US06187769B1,BrCCCCCBr.COc1ccc2c(c1)OC=CNC2=O>>COc1ccc2c(c1)OC=CN(CCCCCBr)C2=O,,CN(C)C=O,,[H-].[Na+],,val
US20080275032A1,CI.O=c1c(C2=NS(=O)(=O)c3cc(I)ccc3N2)c(O)c(-c2cccs2)nn1Cc1ccc(F)cc1>>CN1C(c2c(O)c(-c3cccs3)nn(Cc3ccc(F)cc3)c2=O)=NS(=O)(=O)c2cc(I)ccc21,,CN(C)C=O,O,CCOC(C)=O,[H-].[Na+],val
US05036077,ClCC1CO1.Sc1ccc(Br)cc1>>CC1OC1Sc1ccc(Br)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160159774A1,C=CC(=O)N1CCC[C@@H](Nc2nc(Nc3ccc4c(c3)CNC4)ncc2F)C1.CC(C)(C)OC(=O)N1CCC(C=O)CC1>>C=CC(=O)N1CCC[C@@H](Nc2nc(Nc3ccc4c(c3)CN(CC3CCN(C(=O)OC(C)(C)C)CC3)C4)ncc2F)C1,,CO,,[BH3-]C#N.[Na+],,val
US06511997B1,C[C@H](NC(=O)OCc1ccccc1)C(=O)O.Nc1[nH]nc(-c2ccc(F)cc2)c1-c1ccncc1>>C[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1n[nH]c(-c2ccc(F)cc2)c1-c1ccncc1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20050222171A1,CCOC=O.CN1CCN(c2ccc(CC#N)cc2)CC1>>CN1CCN(c2ccc(C(C#N)C=O)cc2)CC1,,CCO,,,,val
US05362725,ClCC1CO1.c1ccc2c(c1)Cc1ccccc1N1CCNCC21>>OC(CCl)CN1CCN2c3ccccc3Cc3ccccc3C2C1,,CCO,,,,val
US20030069284A1,COc1ccc(C)cc1NC(=O)Nc1cnc(C(=O)c2ccccc2)cn1>>COc1ccc(C)cc1NC(=O)Nc1cnc(C(O)c2ccccc2)cn1,,CCOC(C)=O,CO,[BH4-].[Na+],,val
US06172057B2,CCOC(=O)C1(S(=O)(=O)c2ccc(OC)cc2)CCN(Cc2ccc(C)cc2)CC1>>COc1ccc(S(=O)(=O)C2(C(=O)O)CCN(Cc3ccc(C)cc3)CC2)cc1,,CO,,[Na+].[OH-],,val
US20090270407A1,C=C(Br)C(F)(F)F.OB(O)c1cccnc1>>C=C(c1cccnc1)C(F)(F)F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20130225524A1,CCOC(=O)c1cccc(Nc2c(C(N)=O)cnc3cc(-c4cnc(OC)nc4OC)ccc23)c1>>COc1ncc(-c2ccc3c(Nc4cccc(C(=O)O)c4)c(C(N)=O)cnc3c2)c(OC)n1,,CCO,,[Na+].[OH-],,val
US20080096895A1,CCCC(N)CN.O=C(O)c1ccc(N2CCN(C(=O)c3cc(F)ccc3C(F)(F)F)CC2)nc1>>CCCC1CN=C(c2ccc(N3CCN(C(=O)c4cc(F)ccc4C(F)(F)F)CC3)nc2)N1,,O=P(Cl)(Cl)Cl,,,,val
US05114955,FC(F)(F)c1ccc(COc2ccnc(CSc3nc4cscc4[nH]3)c2)cc1.O=C(OO)c1cccc(Cl)c1>>O=S(Cc1cc(OCc2ccc(C(F)(F)F)cc2)ccn1)c1nc2cscc2[nH]1,,ClCCl,,,,val
US20070244159A1,CC(C)(C)c1cc2cc([N+](=O)[O-])c(F)cc2[nH]1>>CC(C)(C)c1cc2cc(N)c(F)cc2[nH]1,[Ni],CO,,,,val
US20140206681A1,CC1(C)CC2CCC(c3ncc4c(Cl)nccn34)CN2C1=O.O=C1CCC(=O)N1Br>>CC1(C)CC2CCC(c3nc(Br)c4c(Cl)nccn34)CN2C1=O,,CN(C)C=O,,O,,val
US20130331382A1,CCS(=O)(=O)c1ccc(F)c(-c2cn(C)c(=O)cc2Cl)c1.Oc1ccccc1I>>CCS(=O)(=O)c1ccc(Oc2ccccc2I)c(-c2cn(C)c(=O)cc2Cl)c1,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140005168A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OC1CNCCN(c2nc(I)ccc2Br)C1>>CC(C)(C)OC(=O)N1CCN(c2nc(I)ccc2Br)CC(O)C1,,CO,,,,val
US20040023971A1,O=C(Cl)C(=O)Cl.O=C(O)[C@H]1CC[C@@H](C(=O)NCc2ccccc2)N1Cc1ccccc1>>Cl.O=C1C2CCC(C(=O)N1Cc1ccccc1)N2Cc1ccccc1,,ClCCl,,,,val
US05521173,C=O.CNC.O=C(c1ccc(-c2cccs2)cc1)N1Cc2cccn2Cc2ccccc21>>CN(C)Cc1ccc2n1Cc1ccccc1N(C(=O)c1ccc(-c3cccs3)cc1)C2,,C1CCOC1,,CO,,val
US05854232,NC12CC3CC(CC(C3)C1)C2.O=C(Br)CBr>>O=C(CBr)NC12CC3CC(CC(C3)C1)C2,,Cc1ccccc1,,CCN(CC)CC,,val
US20140128390A1,Nc1ccc(-c2ncnc3cc(C4=CCN(C(=O)N5CCOCC5)CC4)sc23)cc1.O=S(=O)(Cl)c1ccc(F)cc1>>O=C(N1CC=C(c2cc3ncnc(-c4ccc(NS(=O)(=O)c5ccc(F)cc5)cc4)c3s2)CC1)N1CCOCC1,,c1ccncc1,,,,val
US20150252030A1,COC(=O)CBr.Cc1cc(C)c(O)c(-c2cccnc2)c1>>COC(=O)COc1c(C)cc(C)cc1-c1cccnc1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150232464A1,CCOC(=O)C(C)(NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12)c1cnc(C)s1>>Cc1ncc(C(C)(CO)NC(=O)c2c(C)nc3c(OCc4c(F)cccc4F)cccn23)s1,,C1CCOC1,CCO,O,[BH4-].[Na+],val
US20120108574A1,CC(C)(C)OC(=O)NC(C)(C)c1ccc(-c2c(-c3ccccc3)nc3n2-c2cccnc2Nc2ccccc2-3)cc1.Cl>>CC(C)(N)c1ccc(-c2c(-c3ccccc3)nc3n2-c2cccnc2Nc2ccccc2-3)cc1.Cl,,C1COCCO1,ClCCl,,,val
US20090018177A1,O=Cc1cccc(C(=O)C(C(=O)c2cccc(F)c2)=C2Nc3ccccc3N2)c1.O=P(CC(F)(F)F)(c1ccccc1)c1ccccc1>>O=C(C(C(=O)c1cccc(/C=C\C(F)(F)F)c1)=C1Nc2ccccc2N1)c1cccc(F)c1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20070254909A1,N#Cc1cnccc1CC(O)c1ccccc1>>NC(=O)c1cnccc1C=Cc1ccccc1,,O,,[K+].[OH-],,val
US20110021522A1,Nc1cccc(-c2ccc(O)nc2)c1.O=C(O)c1cc2cccc(O)c2oc1=O>>O=C(Nc1cccc(-c2ccc(O)nc2)c1)c1cc2cccc(O)c2oc1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04299973,CCOC(=O)C(C(=O)CC(C)(C)O)=C(C)C.NN>>CCOC(=O)C1C(CC(C)(C)O)=NNC1(C)C,,CC(=O)O,,O,,val
US20160243117A1,CC(C)(C)OC(=O)N1CC[C@@H](Oc2c([N+](=O)[O-])cc(C(F)(F)F)cc2[N+](=O)[O-])C1>>CC(C)(C)OC(=O)N1CC[C@@H](Oc2c(N)cc(C(F)(F)F)cc2N)C1,[Pd],CO,,,,val
US20100240688A1,BrCC1CC1.O=c1cc(OCc2ccccc2)cc[nH]1>>O=c1cc(OCc2ccccc2)ccn1CC1CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150094330A1,CC(C)(C)OC(=O)N1CCCc2cccc(I)c21>>Ic1cccc2c1NCCC2,,[Na+],[OH-],C1COCCO1,Cl,val
US20030134854A1,COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(Br)c3)nc12.OCCN1CCOCC1>>COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(OCCN4CCOCC4)c3)nc12,,C1COCCO1,CN(C)C=O,[H-].[Na+],,val
US05750531,CNc1ccccc1.Cc1cc(N2CCc3ccccc3C2)nc(Cl)n1>>Cc1cc(N2CCc3ccccc3C2)nc(N(C)c2ccccc2)n1.Cl,,CN(C)C=O,,,,val
US05502237,ClCC1CO1.O=C(Cc1ccc2ccccc2c1O)NCCO[N+](=O)[O-]>>O=C(Cc1ccc2ccccc2c1OCC1CO1)NCCO[N+](=O)[O-],,CCO,O,[K+].[OH-],,val
US20130338106A1,CSc1sc(-c2cc[nH]n2)c2c1C(=O)CCC2.C[Si](C)(C)CCOCCl>>CSc1sc(-c2ccn(COCC[Si](C)(C)C)n2)c2c1C(=O)CCC2,,C1CCOC1,ClCCl,[H-].[Na+],,val
US20130245049A1,CCCC(C(=O)OC)c1c(C)nc2cc3c(cc2c1-c1ccc(C)cc1)CCC3>>CCCC(C(=O)O)c1c(C)nc2ccc3c(c2c1-c1ccc(C)cc1)CCC3,,CCO,CO,[Na+].[OH-],,val
US20130217709A1,COC(=O)C1CN(C(=O)OCc2ccccc2)CCC1c1ccc(C)c(F)c1>>Cc1ccc(C2CCN(C(=O)OCc3ccccc3)CC2C(=O)O)cc1F,,C1CCOC1,O,CC(=O)O,[Li+].[OH-],val
US20150166558A1,CCOC(=O)COc1ccc([C@H](Cn2c(=O)c3c(n(Cc4c(F)cccc4C(F)(F)F)c2=O)COC32CCN(Cc3ccc(C(F)(F)F)o3)CC2)NC(=O)OC(C)(C)C)cc1>>CCOC(=O)COc1ccc([C@@H](N)Cn2c(=O)c3c(n(Cc4c(F)cccc4C(F)(F)F)c2=O)COC32CCN(Cc3ccc(C(F)(F)F)o3)CC2)cc1,,ClCCl,,Cl,,val
US20090176823A1,CC(C)(C)OC(=O)N(Cc1cc(CO)ccc1Cl)C1CC1.CN.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CNC(=O)OCc1ccc(Cl)c(CN(C(=O)OC(C)(C)C)C2CC2)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20120083488A1,C1COCCN1.CC1(C)c2cc(C(=O)O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21>>CC1(C)c2cc(C(=O)N3CCOCC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20070213341A1,Cc1ccc(F)cc1[C@H]1N(CC(=O)O)C(=O)C[C@@H](c2cccc(Cl)c2)[C@]12C(=O)Nc1cc(Cl)ccc12.Fc1nc(F)nc(F)n1>>Cc1ccc(F)cc1C1N(CC(=O)F)C(=O)CC(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12,,ClCCl,,c1ccncc1,,val
US20120058996A1,CC(C)N(C(=O)OC(C)(C)C)c1ncc(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(=O)NC2CCN(C)CC2)C4)s1>>CC(C)Nc1ncc(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(=O)NC2CCN(C)CC2)C4)s1,,ClCCl,O=C(O)C(F)(F)F,,,val
US04956359,C=CCN=C=O.C[C@@H]1NC[C@H]1Oc1cccc(C(F)(F)F)c1>>C=CCNC(=O)N1C[C@@H](Oc2cccc(C(F)(F)F)c2)[C@@H]1C,,C1CCOC1,O,,,val
US20070054909A1,CCOC(=O)Cc1ccc(N)cc1.O=C=Nc1ccccc1>>CCOC(=O)Cc1ccc(NC(=O)Nc2ccccc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US05763611,CC(=O)SCCI.CCOP(=O)(OCC)C1(P(=O)(OCC)OCC)C=C2C=CCNC2=C1>>CCOP(=O)(OCC)C1(P(=O)(OCC)OCC)C=C2C=CCNC2=C1CCSC(C)=O,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20090082368A1,O=C(O)CCCN1C(=O)c2cccc3cc([N+](=O)[O-])cc(c23)C1=O>>Nc1cc2c3c(cccc3c1)C(=O)N(CCCC(=O)O)C2=O,[Pd],CN(C)C=O,,[H][H],,val
US20130324579A1,Cc1nc2ccccc2n1CCCl.O=[N+]([O-])c1cn[nH]c1>>Cc1nc2ccccc2n1CCn1cc([N+](=O)[O-])cn1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080207703A1,CCOC(=O)c1csc(NC(=O)NCc2ccc(Cl)c(Cl)c2)n1>>O=C(NCc1ccc(Cl)c(Cl)c1)Nc1nc(C(=O)O)cs1,,CCO,,[Na+].[OH-],,val
US20040127574A1,O=C(OCc1ccccc1)c1ccc(Oc2cccnc2)cc1>>O=C(O)c1ccc(Oc2cccnc2)cc1,[Pd],CCO,,,,val
US20090239854A1,C=Cc1ccc(C)nc1.Cc1ccc2[nH]c3c(c2c1)CN(c1ccc(Br)cc1)CC3>>Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(c2ccc(Br)cc2)C1,,CN1CCCC1=O,,[K+].[OH-],,val
US05362878,COc1cc(N)c2ncccc2c1.COc1cc(NC(C)=O)c2ncccc2c1>>COc1cc(NC(C)=O)c2ncccc2c1N,,c1ccncc1,,CC(=O)OC(C)=O,,val
US20110082181A1,Cc1noc(-c2ccc(Br)cc2)c1C(=O)O.O=C(Cl)C(=O)Cl>>Cc1noc(-c2ccc(Br)cc2)c1C(=O)Cl,CN(C)C=O,ClCCl,,,,val
US20110172297A1,CCOC(=O)C1=C(c2ccccc2)COCC1>>CCOC(=O)[C@H]1CCOC[C@H]1c1ccccc1,[Pd],CCO,,,,val
US20160152623A1,C[C@H](c1cc(Cl)ccc1Cn1c(=S)[nH]c(=O)c2[nH]ccc21)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C>>C[C@@H](N)c1cc(Cl)ccc1Cn1c(=S)[nH]c(=O)c2[nH]ccc21,,O,,Cl,N,val
US04625066,CC(CF)(CF)C(=O)CBr.c1nc[nH]n1>>CC(CF)(CF)C(=O)Cn1cncn1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US04251537,CC(=O)c1ccc2c(c1)[C@@H](N1CCCCC1)[C@H](O)C(C)(C)O2>>CC(O)c1ccc2c(c1)[C@@H](N1CCCCC1)[C@H](O)C(C)(C)O2,,CO,O,[BH4-].[Na+],,val
US20030013715A1,CCOC(=O)N=NC(=O)OCC.OCC12CC3CC(CC(C3)C1)C2.Oc1ccc2ncccc2c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>c1cnc2ccc(Oc3ccc4ncccc4c3)cc2c1,,C1CCOC1,,,,val
US20150111885A1,CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cc(C#C[Si](C)(C)C)c(=O)n(C)c2)c1>>C#Cc1cc(-c2cc(NS(=O)(=O)CC)ccc2Oc2ccc(F)cc2F)cn(C)c1=O,,CCO,,O,O=C([O-])[O-].[K+].[K+],val
US20070054916A1,CCN=C=O.Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(N)ncc2c1>>CCNC(=O)Nc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)ccc2n1,,CN(C)C=O,,,,val
US03992392,CSc1c[nH]c2ccccc12>>c1ccc2[nH]ccc2c1,[Ni],,,,,val
US05665718,C1CCC2=NCCCN2CC1.C=CCBr.NCc1nc(-c2ncn3c2[C@@H]2CCCN2C(=O)c2c(Cl)cccc2-3)no1>>C=CCN(CC=C)Cc1nc(-c2ncn3c2[C@@H]2CCCN2C(=O)c2c(Cl)cccc2-3)no1,,CN(C)C=O,,,,val
US20070254925A1,Nc1nc(C(F)(F)F)c(Br)s1.O=C(Cl)c1c(F)cccc1F>>Cc1nc(NC(=O)c2c(F)cccc2F)sc1Br,,C1CCOC1,c1ccncc1,Cl,,val
US20030203951A1,COC(=O)C1COCC1C#N>>COC(=O)C1=C(C#N)COC1,,c1ccncc1,,O,O=S(Cl)Cl,val
US05262441,CCC(CC)Cc1ccc(O)c(Cl)c1.OCc1ccc(Cl)cc1>>CCC(CC)Cc1ccc(OCc2ccc(Cl)cc2)c(Cl)c1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20090105219A1,Cc1ccc2cc3c(cc2n1)C[C@]1(C3)C(=O)Nc2ncccc21.O=[Se]=O>>O=Cc1ccc2cc3c(cc2n1)C[C@]1(C3)C(=O)Nc2ncccc21,,C1COCCO1,O,,,val
US06255333B1,Cc1cc(N)n(-c2c(Cl)cc(C(F)(F)F)cc2Cl)n1.O=C1CCC(=O)N1I>>Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1I,,CC#N,,,,val
US20060287324A1,Cc1nc(C(F)(F)F)ccc1CC(=O)NNc1cc(-c2ccc(Cl)cc2)c(-c2ccccc2Cl)cn1>>Cc1nc(C(F)(F)F)ccc1Cc1nnc2cc(-c3ccc(Cl)cc3)c(-c3ccccc3Cl)cn12,,CCO,,CC(=O)O,,val
US20070265231A1,CC(C=O)=Cc1ccccc1F.CN(N)C(=O)c1ccco1>>CC(C=NN(C)C(=O)c1ccco1)=Cc1ccccc1F,,CO,,,,val
US20160083387A1,CC(=O)O[C@H]1[C@@H]2CCC3(OCCO3)[C@@]2(C)CC[C@@H]1[C@@]1(C)CC[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1CCn1cncn1>>CC(=O)O[C@H]1[C@@H]2CCC(=O)[C@@]2(C)CC[C@@H]1[C@@]1(C)CC[C@H](O)C[C@@H]1CCn1cncn1,,CC(=O)O,,O,,val
US04536355,CC(C)(C)CCOC(=O)CBr.N[PH](=O)O>>CC(C)(C)CCO[PH](N)=O,,CCC(C)=O,,,,val
US20110213143A1,C[C@@H]([C@H](OC(=O)[C@H](CCCNC(=O)OC(C)(C)C)Cc1ncn2c1CCc1ccccc1-2)c1ccccc1)N1CCCC1>>CC(C)(C)OC(=O)NCCC[C@H](Cc1ncn2c1CCc1ccccc1-2)C(=O)O,,CO,,Cl,[Na+].[OH-],val
US20160107997A1,CC(C)CCN(Cc1ccccc1)C(=O)COc1cccc2c1CCN(C(=O)OC(C)(C)C)C2.Cl>>CC(C)CCN(Cc1ccccc1)C(=O)COc1cccc2c1CCNC2.Cl,,C1COCCO1,,,,val
US20060249167A1,CC1CCC(C(C)C)C(=O)C1.C[C@H](O)C(=O)O>>CC(C)[C@@H]1CC[C@@H](C)CC12OC(=O)[C@H](C)O2,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090142297A1,CC(C)(C)OC(=O)N1CCC(C(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1>>O=C1CCC(N2Cc3cc(CNC(=O)C4CCNCC4)ccc3C2=O)C(=O)N1,,CCOCC,ClCCl,Cl,,val
US20070249637A1,COC(=O)[C@@]12C[C@H]1C=CCCCCC[C@H](N)C(=O)N1C[C@H](Oc3nc(-c4cc(C)nn4C)nc4ccsc34)C[C@H]1C(=O)N2.O=C(Oc1ccc([N+](=O)[O-])cc1)OC1CCCC1>>COC(=O)[C@@]12C[C@H]1C=CCCCCC[C@H](NC(=O)OC1CCCC1)C(=O)N1C[C@H](Oc3nc(-c4cc(C)nn4C)nc4ccsc34)C[C@H]1C(=O)N2,,CC(=O)N(C)C,,CCN(CC)CC,O=C([O-])O.[Na+],val
US05208240,CC(=O)Nc1ccc(CCl)cc1.CCOC(=O)C(C)C(=O)OCC>>CCOC(=O)C(C)(Cc1ccc(NC(C)=O)cc1)C(=O)OCC,,C1CCOC1,,O,[H-].[Na+],val
US20120088763A1,CC(C)(C)OC(=O)Cc1ccc(O)cc1.CC(C)c1nnc2ccc(I)cn12.CN1CCCC1=O>>CC(C)c1nnc2ccc(Oc3ccc(CC(N)=O)cc3)cn12,Cl[Cu],CCOCC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140329820A1,FC(F)(F)CI.c1cc2cn[nH]c2cn1>>FC(F)(F)Cn1ncc2c1CNCC2,O=[Pt]=O,,,,,val
US20060040966A1,CC(C)(C)OC(=O)N1Cc2cc(N)ccc2C(C)(C)C1.O=C(Cl)c1cccnc1Cl>>CC(C)(C)OC(=O)N1Cc2cc(NC(=O)c3cccnc3Cl)ccc2C(C)(C)C1,,ClCCl,,O=C([O-])O.[Na+],,val
US04983633,CN(C)CCOc1ccc(CN)cc1.COc1ccc(S(=O)(=O)N(C)C)cc1C(=O)O>>COc1ccc(S(=O)(=O)N(C)C)cc1C(=O)NCc1ccc(OCCN(C)C)cc1,,C1CCOC1,,CCN(CC)CC,CCOC(=O)Cl,val
US20140179698A1,CC(=O)Cl.CCOCc1ccc(C)c(N)c1>>CCOCc1ccc(C)c(NC(C)=O)c1,,ClCCl,,CCN(CC)CC,,val
US05374772,CCCCCCCCCCCCCCBr.COC(=O)c1cc(O)cc(OCCCOc2ccc(OCc3ccccc3)cc2)c1>>CCCCCCCCCCCCCCOc1cc(OCCCOc2ccc(OCc3ccccc3)cc2)cc(C(=O)OC)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20040259843A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@H](C(=O)O)C1.CCN=C=NCCCN(C)C.On1nnc2ccccc21>>CC(C)(C)OC(=O)N[C@H]1CC[C@@H](C(=O)NCc2ccccn2)C1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,Cl,val
US20040053942A1,N#Cc1ccc2c(-c3ccncc3)c(-c3ccc(F)cc3)nn2c1.[OH-]>>NC(=O)c1ccc2c(-c3ccncc3)c(-c3ccc(F)cc3)nn2c1,,CCOCC,,Cl,,val
US20100120880A1,Cc1csc2nc3ccccc3n12.O=[N+]([O-])c1ccc(CCl)cc1>>Cc1csc2n1c1ccccc1[n+]2Cc1ccc([N+](=O)[O-])cc1.[Cl-],,CC(C)=O,,,,val
US20130331387A1,COC(=O)c1scc(C)c1Br.NS(=O)(=O)c1ccc(B(O)O)cc1>>COC(=O)c1scc(C)c1-c1ccc(S(N)(=O)=O)cc1,,CCO,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20160221998A1,Nc1cc(Br)ccn1.OB(O)c1ccc(F)nc1>>Nc1cc(-c2ccc(F)nc2)ccn1,,O,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20120035237A1,CC(C)Br.O=C(Nc1c(F)cccc1F)c1ccn(Cc2cc(Cl)ccc2O)n1>>CC(C)Oc1ccc(Cl)cc1Cn1ccc(C(=O)Nc2c(F)cccc2F)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090269420A1,Clc1cc(Cl)ncn1.OC1CNC1>>OC1CN(c2cc(Cl)ncn2)C1,,O,,[Na+].[OH-],,val
US04604397,BrBr.COc1ccc2c(c1)C(CCCN)=CCO2>>COc1ccc2c(c1)C(=CCCN)C(Br)CO2,,CCOC(C)=O,,CCN(CC)CC,Cl,val
US05451601,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O[C@H]1CCC(c2ccccc2)(c2ccccc2)[C@@H]2CNC[C@H]12>>CC(C)(C)OC(=O)N1C[C@@H]2[C@@H](O)CCC(c3ccccc3)(c3ccccc3)[C@@H]2C1,CN(C)c1ccncc1,ClCCl,,,,val
US20150126449A1,Cc1ccc(F)c(C#N)c1Cl.NN>>Cc1ccc2[nH]nc(N)c2c1Cl,,CCO,,O,,val
US20100190768A1,O=C(c1ccc(Cl)cc1)c1cc[nH]c1.O=[N+]([O-])c1ccc2c(C3(C(F)(F)F)CO3)cn(Cc3ccccc3)c2c1>>O=C(c1ccc(Cl)cc1)c1ccn(CC(O)(c2cn(Cc3ccccc3)c3cc([N+](=O)[O-])ccc23)C(F)(F)F)c1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20150376176A1,CC(C)(N)COc1cccc([N+](=O)[O-])c1C#N.O=C(O)c1ccncc1>>CC(C)(COc1cccc([N+](=O)[O-])c1C#N)NC(=O)c1ccncc1,,CN(C)C=O,ClCCl,ClCCCl,On1nnc2ccccc21,val
US06172085B2,Cc1c(C)c2c(c(C)c1NC(=O)OC(C)(C)C)CC(C)(CN1CCC(CCNC(c3ccccc3)c3ccccc3)CC1)O2>>Cc1c(C)c2c(c(C)c1N)CC(C)(CN1CCC(CCNC(c3ccccc3)c3ccccc3)CC1)O2,,CCO,,Cl,O=C([O-])O.[Na+],val
US05130313,Fc1ccc2[nH]cc(C3=CCNCC3)c2c1.O=S1(=O)N(CCCCl)c2cccc3c2N1CCC3>>O=S1(=O)N(CCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c2cccc3c2N1CCC3,,C1CCOC1,CN(C)C=O,O=C([O-])O.[Na+],,val
US20150307459A1,Fc1ccccc1Br.Oc1ccc(Cl)cc1>>Clc1ccc(Oc2ccc(Br)cc2)cc1,,CN1CCCC1=O,,O,[K+].[OH-],val
US20090298815A1,CC(C)(C)OC(=O)NC(C)(C)c1nc(-c2cccc(N)c2F)c(-c2ccnc(Cl)n2)s1.O=S(=O)(Cl)c1c(F)cccc1F>>CC(C)(C)OC(=O)NC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(Cl)n2)s1,,c1ccncc1,,,,val
US20130059853A1,CCCBr.COc1c(OC(F)F)ccc(Br)c1O>>CCCOc1c(Br)ccc(OC(F)F)c1OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US06335344B1,C#Cc1cccc(N)c1.CSc1c2c(cc3c1=NCN=C3)=NC=N2.Cl>>C#Cc1cccc(NC2C3=NC=NC3=Cc3cncnc32)c1.Cl,,CC(C)(C)O,,c1ccncc1,,val
US20040023999A1,CCOC(=O)C(O)(CC1(c2cc(F)ccc2OC)CC1)C(F)(F)F>>COc1ccc(F)cc1C1(CC(=O)C(F)(F)F)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030181466A1,COC(=O)C=NNc1ccc(Cl)cc1.O=C1CCC(=O)N1Br>>COC(=O)C(Br)=NNc1ccc(Cl)cc1,,C1CCOC1,,,,val
US20090264445A1,CC1(C)OC[C@@H](Cn2ccc(N)n2)O1.O=C(O)C(CC(C(F)(F)F)C(F)(F)F)N1CC(Oc2ccccc2Cl)=CC1=O>>CC1(C)OC[C@@H](Cn2ccc(NC(=O)C(CC(C(F)(F)F)C(F)(F)F)N3CC(Oc4ccccc4Cl)=CC3=O)n2)O1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20110224198A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1c(C(=O)N[C@H]2CCCC[C@@H]2N)cc(Br)c2ccccc12>>CC(C)(C)OC(=O)N[C@H]1CCCC[C@@H]1NC(=O)c1cc(Br)c2ccccc2c1N,,ClCCl,,,,val
US20130190330A1,N=C(N)c1cccc(C(F)(F)F)c1.NNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C2CC2)c1=O>>O=c1n(Cc2nnc(-c3cccc(C(F)(F)F)c3)[nH]2)nc(-c2ccc(Cl)cc2)n1C1CC1,,CN(C)C=O,,Cl,,val
US09248117B2,COCCOCCOCC[N+](C)(C)CCC(C)(C)NC(=O)OCc1ccccc1.Cc1ccc(S(=O)(=O)[O-])cc1>>COCCOCCOCC[N+](C)(C)CCC(C)(C)N.Cc1ccc(S(=O)(=O)[O-])cc1,[Pd],CO,,,,val
US20160254098A1,CCCC(=O)[O-].CCCCn1cc[n+](C)c1C>>CCCC(=O)[O-].CCCCn1cc[n+](C)c1C,,O,,[I-].[Na+],,val
US20090306041A1,Brc1cccc(Br)c1.CN(C)c1ccc2c(=O)[nH]ccc2c1>>CN(C)c1ccc2c(=O)n(-c3cccc(Br)c3)ccc2c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110136802A1,COc1cc(OC)c2c(c1)[C@]1(C)CC[C@H]3C(C)(C)CCC[C@]3(C)[C@H]1CO2>>COc1cc(O)c2c(c1)[C@]1(C)CC[C@H]3C(C)(C)CCC[C@]3(C)[C@H]1CO2,,ClCCl,,BrB(Br)Br,,val
US20130210844A1,C1COCCN1.Cc1nc(Cl)c2cccc([N+](=O)[O-])c2n1>>Cc1nc(N2CCOCC2)c2cccc([N+](=O)[O-])c2n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040116732A1,COC(OC)C(C#N)=NO.N.NNc1ccccc1>>Nc1c(N=O)cnn1-c1ccccc1,,CO,O,Cl,,val
US20090324581A1,CI.O=Cc1c([N+](=O)[O-])ccc(OCc2ccccc2)c1O>>COc1c(OCc2ccccc2)ccc([N+](=O)[O-])c1C=O,,ClCCl,,O,O=C([O-])[O-].[K+].[K+],val
US20140323470A1,CCN(C(C)C)C(C)C.C[C@H]1CCCCN1c1nnc2ccc(O[C@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCO)c4)c4ccccc43)cn12>>C[C@H]1CCCCN1c1nnc2ccc(O[C@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCN(C)C)c4)c4ccccc43)cn12,,ClCCl,,CS(=O)(=O)Cl,,val
US05045552,COCCCOc1ccnc(CCl)c1.Sc1nc2ccccc2[nH]1>>COCCCOc1ccnc(CSc2nc3ccccc3[nH]2)c1,,CCO,,[Na+].[OH-],,val
US05308830,BrCC1CCCCC1.Sc1nc[nH]n1>>c1nc(SCC2CCCCC2)n[nH]1,,CO,,C[O-].[Na+],,val
US06235731B1,BrCCCc1ccccc1.CC(C)(C)OC(=O)N1CCCNCC1>>CC(C)(C)OC(=O)N1CCCN(CCCc2ccccc2)CC1,,CCO,,CCN(CC)CC,CCOC(C)=O,val
US20020037892A1,C1CNCCN1.O=[N+]([O-])c1cc(F)ccc1S(=O)(=O)c1ccccc1>>O=[N+]([O-])c1cc(N2CCNCC2)ccc1S(=O)(=O)c1ccccc1,,CC#N,ClCCl,O,O=C([O-])[O-].[K+].[K+],val
US20120083469A1,C=CCCC(NC(=O)OCc1ccccc1)(C(=O)OCC)C(=O)OCC>>C=CCCC(NC(=O)OCc1ccccc1)(C(=O)O)C(=O)OCC,,CCO,,CC(=O)O,[K+].[OH-],val
US20140349991A1,COC(=O)c1ccc(CN2CCC(c3oc4c(C)c(O)ccc4c(=O)c3C)CC2)cc1>>Cc1c(C2CCN(Cc3ccc(C(=O)O)cc3)CC2)oc2c(C)c(O)ccc2c1=O,,CO,,[Na+].[OH-],,val
US20050038072A1,N#Cc1ccccc1CBr.O=C1CCNCC1C(c1ccc(F)cc1)c1ccc(F)cc1>>N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20150259721A1,NCCCCCC(=O)O.O=C(Cl)OCCCl>>O=C(O)CCCCCNC(=O)OCCCl,,C1COCCO1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US20100081680A1,NS(=O)(=O)c1ccc(C(F)(F)F)cc1.O=Cc1ccccc1I>>O=S(=O)(/N=C/c1ccccc1I)c1ccc(C(F)(F)F)cc1,Cl[Ti](Cl)(Cl)Cl,C1CCOC1,ClCCl,CCN(CC)CC,,val
US20110021522A1,Nc1cccc(-c2ccc(Oc3ccccc3)cc2)c1.O=C(O)c1cc2cccc(O)c2oc1=O>>O=C(Nc1cccc(-c2ccc(Oc3ccccc3)cc2)c1)c1cc2cccc(O)c2oc1=O,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160200681A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNC1CCc2c1cn(S(=O)(=O)c1cccc(F)c1)c2-c1ccc(F)cc1F>>CN(C(=O)OC(C)(C)C)C1CCc2c1cn(S(=O)(=O)c1cccc(F)c1)c2-c1ccc(F)cc1F,,CCOC(C)=O,,O,,val
US20140249131A1,CSc1ncc(C=O)c(Nc2cccc(NC(=O)OC(C)(C)C)c2)n1.C[Mg]Br>>CSc1ncc(C(C)O)c(Nc2cccc(NC(=O)OC(C)(C)C)c2)n1,,CCOCC,,C1CCOC1,[Cl-].[NH4+],val
US20150105373A1,O=C(CBr)c1ccc(OC(F)(F)F)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(C[P+](c1ccccc1)(c1ccccc1)c1ccccc1)c1ccc(OC(F)(F)F)cc1.[Br-],,CCOCC,,,,val
US20090286798A1,CCOC(=O)[C@H]1C[C@H](OC(C)=O)CN1S(=O)(=O)c1ccc(C)cc1>>Cc1ccc(S(=O)(=O)N2C[C@@H](O)C[C@@H]2CO)cc1,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05124336,CSc1ccc(CCl)cc1.Nc1ccc(F)cc1[N+](=O)[O-]>>CSc1ccc(CNc2ccc(F)cc2[N+](=O)[O-])cc1,II,,,Cl,CC(=O)[O-].[Na+],val
US20090275578A1,CC(c1ccc(Cl)cc1)N1Cc2cc(OC(F)F)cc(I)c2C1=O.Cl[Cu]>>CC(c1ccc(Cl)cc1)N1Cc2cc(OC(F)F)cc(Cl)c2C1=O,Cl[Cu],CN(C)C=O,,ClCCl,,val
US05684032,BrBr.CCOC(=O)c1cc2cc(OCc3ccccc3)ccc2[nH]1>>CCOC(=O)c1[nH]c2ccc(OCc3ccccc3)cc2c1Br,,CN(C)C=O,,,,val
US20050131017A1,CC(C)(C)OC(=O)[C@@H](NC(=O)COc1ccccc1)C(C)(C)C>>CC(C)(C)[C@H](NC(=O)COc1ccccc1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060258741A1,CN(C)C[C@@H]1CCCC[C@H]1c1cccc(O)c1.COC(=O)[C@H]1O[C@H](Br)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CN(C)C[C@@H]1CCCC[C@H]1c1cccc(OC2OC(C(=O)O)C(O)C(O)C2O)c1,,CO,O,[Li+].[OH-],,val
US20060040972A1,CS(=O)(=O)c1ccc(CC(=O)c2c(O)c3cccnc3n(-c3ccccc3)c2=O)cc1.NN>>CS(=O)(=O)c1ccc(Cc2n[nH]c3c2c(=O)n(-c2ccccc2)c2ncccc32)cc1,,CN(C)C=O,,O,,val
US04089960,CCN1CCCC1CN.COC(=O)c1cnccc1OC.Cc1ccccc1C>>CCN1CCCC1CNC(=O)c1cnccc1OC.OCc1ccccc1,,Cc1ccccc1C,,,,val
US20150361100A1,OCc1cc2ccccn2c1-c1ccc(CN2CCOCC2)cc1>>O=Cc1cc2ccccn2c1-c1ccc(CN2CCOCC2)cc1,O=[Mn]=O,,,,,val
US04034040,CCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCC)Cc1cccc(C#N)c1.N>>NCc1cccc(CN)c1,,CCO,,CCCCCC,,val
US06013658,C=CC[Mg]Br.CN(C(=O)OC(C)(C)C)[C@@H](C=O)Cc1ccccc1>>C=CCC(O)[C@@H](Cc1ccccc1)N(C)C(=O)OC(C)(C)C,,CCOCC,O,[Cl-].[NH4+],,val
US04221805,C1CCNC1.ClCc1ccccc1Cl>>Clc1ccccc1CN1CCCC1,,Cc1ccccc1,,,,val
US20100310512A1,COC(=O)c1cc(-c2cnc(C3CCCN3C(=O)OC(C)(C)C)[nH]2)ccc1Br>>CC(C)(C)OC(=O)N1CCCC1c1ncc(-c2ccc(Br)c(CO)c2)[nH]1,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20150141406A1,CC1(C)OB(c2cccc(S(N)(=O)=O)c2)OC1(C)C.COc1nccc2c1c(OS(=O)(=O)C(F)(F)F)nn2C1CCCC1>>COc1nccc2c1c(-c1cccc(S(N)(=O)=O)c1)nn2C1CCCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Na+].[Na+],val
US20140336377A1,[N-]=[N+]=NCc1cccc(OCC(F)(F)F)n1>>NCc1cccc(OCC(F)(F)F)n1,[Pd],CO,,,,val
US20110251204A1,CC[C@H](C)[C@@H](CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1)NC(=O)OC(C)(C)C>>CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150329538A1,Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)CNC(=O)OC(C)(C)C>>Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)CN,,ClCCl,,O=C(O)C(F)(F)F,,val
US04959362,CCCCCCCCCCCCCCCCCCOC1=C(O)[C@@H]([C@@H](O)CO)OC1=O.O=C(Cl)c1ccccc1>>CCCCCCCCCCCCCCCCCCOC1=C(OC(=O)c2ccccc2)[C@@H]([C@@H](O)CO)OC1=O,,ClC(Cl)Cl,,Cl,c1ccncc1,val
US20050239780A1,Cl.N#CCc1ccccc1N>>Cl.N=C1Cc2ccccc2N1,,C1CCOC1,,,,val
US20020161022A1,NN.O=C(c1ccccc1)c1cc([N+](=O)[O-])ccc1Cl>>O=[N+]([O-])c1ccc2[nH]nc(-c3ccccc3)c2c1,,CCO,,O,O,val
US20020165221A1,COC(=O)[C@@H]1C[C@@H](N(Cc2cccc(OC)c2)C(=O)CC(C)(C)C)CN1Cc1ccc2c(c1)OCO2>>COc1cccc(CN(C(=O)CC(C)(C)C)[C@@H]2C[C@@H](C(=O)O)N(Cc3ccc4c(c3)OCO4)C2)c1,,O,,CO,[Li+].[OH-],val
US20070249637A1,C=CCCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Oc2nc(-c3ccccn3)nc3sccc23)C[C@H]1C(=O)N[C@]1(C(=O)OC)C[C@H]1C=C>>COC(=O)[C@@]12C[C@H]1C=CCCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Oc3nc(-c4ccccn4)nc4sccc34)C[C@H]1C(=O)N2,,ClCCl,,,,val
US20130053409A1,COc1cc(N(C)CCN(C)C)c([N+](=O)[O-])cc1Nc1nccc(-c2cnn3c2CCCC3)n1>>COc1cc(N(C)CCN(C)C)c(N)cc1Nc1nccc(-c2cnn3c2CCCC3)n1,[Fe],CCO,,O,[Cl-].[NH4+],val
US20160102059A1,COc1cc([N+](=O)[O-])ccc1S(=O)(=O)CCCO.CS(=O)(=O)Cl>>COc1cc([N+](=O)[O-])ccc1S(=O)(=O)CCCOS(C)(=O)=O,CN(C)c1ccncc1,c1ccncc1,,,,val
US05191084,CCOC(=O)C=Cc1cncc(Br)c1>>OCC=Cc1cncc(Br)c1,,CCOCC,,CC(C)C[Al+]CC(C)C.[H-],,val
US20100120859A1,COCCCc1cc(O)cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@@H]2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)c1.N#CCCCBr>>COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@@H]2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)cc(OCCCC#N)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090137609A1,CCC(CC)(c1ccc(/C=C/C(O)(C(F)(F)F)C(F)(F)F)c(C)c1)c1ccc(B2OC(C)(C)C(C)(C)O2)c(C)c1.CCOC(=O)Cc1ccc(Br)nc1>>CCOC(=O)Cc1ccc(-c2ccc(C(CC)(CC)c3ccc(/C=C/C(O)(C(F)(F)F)C(F)(F)F)c(C)c3)cc2C)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20020137974A1,COc1ccccc1Cl.OB(O)c1ccccc1>>COc1ccccc1-c1ccccc1,,C1COCCO1,,[Cs+].[F-],,val
US20110301031A1,CON1CCC2(CC1)C(OCc1ccccc1)=C(c1c(C)cc(C)cc1C)C(=O)N2C>>CON1CCC2(CC1)C(O)=C(c1c(C)cc(C)cc1C)C(=O)N2C,[Pd],CO,O,,,val
US20060178367A1,CC(C)(C)c1ccc(C(=O)Cl)cc1.Cc1c(N)cccc1-c1cn2ccnc2c(Nc2ccc(C#N)cc2)n1>>Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn2ccnc2c(Nc2ccc(C#N)cc2)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20120015942A1,COC(=O)C1(C)CCc2ccc(OC)cc2C1=O>>COC(=O)C1(C)CCc2ccc(OC)cc2C1,,ClCCl,O=C(O)C(F)(F)F,CC[SiH](CC)CC,,val
US20070293497A1,C[C@H]1C[C@@H]1CNc1cc(-c2ncc([C@](C)(N)Cc3ccccc3)o2)cc(N(C)S(C)(=O)=O)n1.O=C1CCC(=O)N1Cl>>C[C@H]1C[C@@H]1CNc1cc(-c2ncc([C@](C)(N)Cc3ccccc3)o2)c(Cl)c(N(C)S(C)(=O)=O)n1,,ClCCl,,,,val
US20140038957A1,CO/C=C1\CN(C(=O)OC(C)(C)C)CCC1=O>>COCC1CN(C(=O)OC(C)(C)C)CCC1=O,[Pd],CO,,,,val
US20130172312A1,CC1(C(=O)O)CCC1.CCOc1ccc(OC2CN(c3ccc([C@H](C)N)cc3)C2)cc1>>CCOc1ccc(OC2CN(c3ccc([C@H](C)NC(=O)C4(C)CCC4)cc3)C2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20060128783A1,BrB(Br)Br.COc1ccc2[nH]c(C(N)=O)c(S(=O)(=O)N3CCOCC3)c2c1>>NC(=O)c1[nH]c2ccc(O)cc2c1S(=O)(=O)N(CCO)CCBr,,ClCCl,,CCOC(C)=O,O=C([O-])O.[Na+],val
US20020042429A1,COC(=O)c1ccc(-c2ccccc2)n1C>>Cn1c(C(=O)O)ccc1-c1ccccc1,,C1CCOC1,O,CO,[Li+].[OH-],val
US20140371199A1,CC(C)(C)OC(=O)N1CCC(N2CCNCC2)CC1.N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)O)cc4)cn23)cc1>>CC(C)(C)OC(=O)N1CCC(N2CCN(C(=O)c3ccc(-c4ccc5ncc(-c6ccc(C#N)cc6)n5c4)cc3)CC2)CC1,,CN(C)C=O,O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130005855A1,ClCC1CO1.Oc1ccc(Oc2ccccc2)cc1>>OC(CCl)COc1ccc(Oc2ccccc2)cc1,,CCO,,,,val
US20080125468A1,COC(=O)CCNC(=O)c1ccc(OCc2ccc(-c3ccc(C(F)(F)F)cc3)cc2C)cc1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)ccc1COc1ccc(C(=O)NCCC(=O)O)cc1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20070015764A1,CCCOc1cc(O)c(CC)cc1CCC(O)(CC1=CC(=O)OC(C)(C)O1)C1CCCC1>>CCCOc1cc(O)c(CC)cc1CCC1(C2CCCC2)CC(=O)CC(=O)O1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20100016578A1,C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)NS(=O)(=O)C1CC1.CC(=O)Cl>>C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)C1CC1.Cl,,CO,,,,val
US20120172411A1,CCCCC/C=C\C/C=C\CCCCCCCCOS(C)(=O)=O.O=C1OCCC1O>>CCCCC/C=C\C/C=C\CCCCCCCCOC1CCOC1=O,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20040121964A1,C#C[C@H]1CC[C@@H](C#N)N1C(=O)CCl.N[C@@H]1CCC[C@H]1O>>C#C[C@H]1CC[C@@H](C#N)N1C(=O)CNC1CCC[C@@H]1O,,CC#N,,CCN(CC)CC,Cl,val
US06127361,COc1ccc(CCN2C[C@@H](O)C[C@@H]2CN2c3ccccc3COc3ccccc32)cc1.Cl>>COc1ccc(CCN2C[C@@H](O)C[C@@H]2CN2c3ccccc3COc3ccccc32)cc1.Cl,,ClCCl,,CCOCC,,val
US20150361053A1,COC(=O)c1ccc(Br)cc1N.S=C(Cl)Cl>>COC(=O)c1ccc(Br)cc1N=C=S,,ClCCl,,O=C([O-])O.[Na+],,val
US20110112100A1,BrBr.CC(C)(C)OC(=O)Oc1ccc2cccnc2c1>>CC(C)(C)OC(=O)Oc1ccc2cc(Br)cnc2c1,,ClC(Cl)(Cl)Cl,,c1ccncc1,,val
US05028596,CC(=O)OC(C)=O.O=c1[nH]c(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)cc1I.c1ccncc1>>CC(=O)OC[C@H]1O[C@@H](n2cc(I)c(=O)[nH]c2=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,c1ccncc1,,,,val
US20110288066A1,CCCS(=O)(=O)c1cccc(C#Cc2c(OCC(=O)OC(C)(C)C)ccc3ccccc23)c1>>CCCS(=O)(=O)c1cccc(C#Cc2c(OCC(=O)O)ccc3ccccc23)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090048258A1,CCOc1ccc(C(=O)CCC(=O)O)cc1.Nc1cc(-c2ccccc2)c(Cc2ccccc2)s1>>CCOc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccccc3)c(Cc3ccccc3)s2)cc1,,CC#N,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20120258950A1,CC(C)(CO[Si](C)(C)C(C)(C)C)n1cc(I)c2cnc(Cl)nc21.CON(C)C(=O)c1cncc(N=C(c2ccccc2)c2ccccc2)c1>>CC(C)(CO[Si](C)(C)C(C)(C)C)n1cc(C(=O)c2cncc(N=C(c3ccccc3)c3ccccc3)c2)c2cnc(Cl)nc21,,C1CCOC1,,CC(C)[Mg]Cl,,val
US04735952,CCOC(=O)c1cnc2cc(C(F)(F)F)ccc2c1Cl.Nc1ccc(C(=O)O)cc1>>CCOC(=O)c1cnc2cc(C(F)(F)F)ccc2c1Nc1ccc(C(=O)O)cc1.Cl,,C1CCOC1,,,,val
US20080306107A1,Cc1cc(C(F)(F)F)c2c(N)c(C(=O)O)sc2n1.Cc1ccccc1CCN>>Cc1cc(C(F)(F)F)c2c(N)c(C(=O)NCCc3ccccc3C)sc2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120196864A1,CCN1C(=N)/C(=C/c2ccc(OCc3ccc(OC)cc3)c(OC)c2)NC1=O>>CCN1C(=N)/C(=C/c2ccc(O)c(OC)c2)NC1=O,,O=C(O)C(F)(F)F,,,,val
US20070213376A1,CC(C)S(=O)(=O)N[C@@H]1CC[C@@H](CNC([NH-])=S)CC1.O=C(CCl)c1cccc(F)n1>>CC(C)S(=O)(=O)N[C@@H]1CC[C@@H](CNc2nc(-c3cccc(F)n3)cs2)CC1,,CCO,,CCN(C(C)C)C(C)C,,val
US20080176926A1,CCc1cc(C=CC(=O)c2sc(C)c3c2CCC(C)(C)C3)cc(C)c1C=CC(=O)O>>CCc1cc(CCC(=O)c2sc(C)c3c2CCC(C)(C)C3)cc(C)c1CCC(=O)O,[Pd],CCO,,CCN(C(C)C)C(C)C,,val
US20020077327A1,CC(=O)c1ccc(O)cc1.CC(C)CBr>>CC(=O)c1ccc(OCC(C)C)cc1,,CCO,,O,O=C([O-])[O-].[K+].[K+],val
US20130059896A1,CN(C)CCCC(=O)O.Nc1ncc(-c2cc(C(F)F)nn2-c2c(Cl)cccc2Cl)s1>>CN(C)CCCC(=O)Nc1ncc(-c2cc(C(F)F)nn2-c2c(Cl)cccc2Cl)s1,,CC(=O)OC(C)C,,CCN(C(C)C)C(C)C,Cl,val
US05981572,OCCc1cccc(O)c1CCO>>OCCc1cccc2c1CCO2,,O,,Cl,,val
US20150307460A1,C=CCC(C(=O)c1ccc(Oc2ccc(Cl)cc2)cc1Cl)n1cncn1.OO>>OC1(c2ccc(Oc3ccc(Cl)cc3)cc2Cl)OCCCC1n1cncn1,,C1CCOC1,COC(C)(C)C,B1C2CCCC1CCC2,[Na+].[OH-],val
US20070010671A1,CN(C)c1nc(N[C@@H]2CC[C@H](CNC(=O)c3cccc([N+](=O)[O-])c3)CC2)nc2ccccc12>>CN(C)c1nc(N[C@@H]2CC[C@H](CNC(=O)c3cccc(N)c3)CC2)nc2ccccc12,[Pd],CCO,,,,val
US20060241137A1,CNC(=S)NNC(=O)c1cc2ccccc2s1>>Cn1c(S)nnc1-c1cc2ccccc2s1,,O,,[Na+].[OH-],,val
US20160090387A1,CC(C)n1cnc2c(NCCc3ccccc3)nc(Cl)nc21.CC[C@@H](N)CO>>CC[C@H](CO)Nc1nc(NCCc2ccccc2)c2ncn(C(C)C)c2n1,,O,,,,val
US20140080808A1,CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(C3(c4ccc(-c5ncccc5C(F)(F)F)cc4)CC3)n2CCS1>>CC1(CO)Cc2nnc(C3(c4ccc(-c5ncccc5C(F)(F)F)cc4)CC3)n2CCS1,,CO,,Cl,,val
US05563150,CN(C)Cc1c[nH]c2ncccc12.FC1=C(/C=C/c2ccccc2)CCN(Cc2ccccc2)C1>>FC1=C(/C=C/c2ccccc2)CCN(Cc2c[nH]c3ncccc23)C1,,Cc1ccccc1,ClCCl,CC(Cl)OC(=O)Cl,,val
US20050203078A1,CCOC(=O)c1ccc(N2C(=O)OCC2C)c(Cl)c1>>CC1COC(=O)N1c1ccc(C(=O)O)cc1Cl,,CO,,[Li+].[OH-],,val
US20110288066A1,CS(=O)(=O)c1cc(Br)ccc1I.OB(O)c1ccccc1>>CS(=O)(=O)c1cc(Br)ccc1-c1ccccc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,,[Cs+].[F-],,val
US20050153981A1,COc1ccc2cc(C(=O)C(C)Br)ccc2c1Cl.Cl.Cl.O=C(CN1CCNCC1)c1ccccc1>>COc1ccc2cc(C(=O)C(C)N3CCN(CC(=O)c4ccccc4)CC3)ccc2c1Cl.Cl.Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20160130214A1,CCC(=O)N[C@H]1CC[C@@H](N(C)C(=O)OC(C)(C)C)C1.O=C(O)C(F)(F)F>>CCC(=O)N[C@H]1CC[C@@H](NC)C1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20110065691A1,COc1ccc(N2CCN(C(=O)Cc3n[nH]c([N+](=O)[O-])n3)[C@@H](Cc3ccccc3)C2)cc1OC(C)C>>COc1ccc(N2CCN(C(=O)Cc3nc(N)n[nH]3)[C@@H](Cc3ccccc3)C2)cc1OC(C)C,[Pd],CO,,O=C[O-].[NH4+],,val
US05670493,OC[C@@H]1CC[C@@H](CO)CC1>>O=C[C@@H]1CC[C@@H](C=O)CC1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20080076758A1,COc1ccc(CBr)cc1.Oc1cc(Br)cc(F)c1F>>COc1ccc(COc2cc(Br)cc(F)c2F)cc1,,C1CCOC1,,[H-].[Na+],,val
US20140343092A1,Cc1c(-c2c(C(OC(C)(C)C)C(=O)O)n(C)c(=O)c3c2ccn3Cc2ccccc2)ccc2c1CCCO2>>Cc1c(-c2c(C(OC(C)(C)C)C(=O)O)n(C)c(=O)c3[nH]ccc23)ccc2c1CCCO2,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20110065706A1,CC(C)c1noc(N2CCN(c3ncc(O)cn3)[C@H](C)C2)n1.N#Cc1cnccc1CCl>>CC(C)c1noc(N2CCN(c3ncc(OCc4ccncc4C#N)cn3)[C@H](C)C2)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20040122050A1,O=S(=O)(NC1CCC(c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CC[C@@H](O)C1>>O=C1CCN(S(=O)(=O)NC2CCC(c3cc(F)ccc3F)(S(=O)(=O)c3ccc(Cl)cc3)CC2)C1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20110098429A1,C=C(c1cccc(-c2ccccc2OC)c1)c1cccc(C(C)(C)C)c1OCc1ccccc1>>COc1ccccc1-c1cccc(C(C)c2cccc(C(C)(C)C)c2O)c1,[Pd],CCOC(C)=O,CO,,,val
US20080139610A1,CC(C)(C)CC(=O)Cl.Nc1c(Cl)cc(Br)cc1C(F)(F)F>>CC(C)(C)CC(=O)Nc1c(Cl)cc(Br)cc1C(F)(F)F,,CC#N,,O,,val
US20130065925A1,CCCC(F)CN1CCC(NC(=O)OCc2ccccc2)CC1>>CCCC(F)CN1CCC(N)CC1,[Pd],CO,,,,val
US20030225269A1,CI.Oc1cccc2ocnc12>>COc1cccc2ocnc12,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100261728A1,FC(F)(F)c1ccc([C@H]2NCCc3ccccc32)cc1.O=C(O)C1CCC(F)(F)CC1>>O=C(C1CCC(F)(F)CC1)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100190782A1,CN(C)c1ccccc1C=O.NCCO>>CN(C)c1ccc(CNCCO)cc1,,CCO,O,[Na+].[OH-],,val
US20120258949A1,CN1CCCC2(C1)NC(=O)c1cc(/C=C/C(=O)O)ccc1O2.NOC1CCCCO1>>CN1CCCC2(C1)NC(=O)c1cc(/C=C/C(=O)NOC3CCCCO3)ccc1O2,,ClCCl,,ClCCCl,On1nnc2ccccc21,val
US20150191478A1,C1COCCN1.CCOC(OCC)c1cc2cncc(-c3cccc(C=O)c3)c2o1>>CCOC(OCC)c1cc2cncc(-c3cccc(CN4CCOCC4)c3)c2o1,,C1CCOC1,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040242668A1,CC(C)(Cc1c[nH]c2c(O)cccc12)NC(=O)OC(C)(C)C.COC(=O)c1ccc(Cl)nc1>>COC(=O)c1ccc(Oc2cccc3c(CC(C)(C)NC(=O)OC(C)(C)C)c[nH]c23)nc1,,CN(C)C=O,,O,[H-].[Na+],val
US20080051430A1,CCC(=O)c1cc(Cl)c(C)cc1C1=CCN(C(=O)OC(C)(C)C)CC1>>CCC(O)c1cc(Cl)c(C)cc1C1CCN(C(=O)OC(C)(C)C)CC1,O=[Pt],CCO,,,,val
US05624948,COC(=O)C(C)(C)Cc1ccc(CCN2CCCNCCC2)cc1.Clc1ccc(Cn2c(Br)nc3ccccc32)cc1>>COC(=O)C(C)(C)Cc1ccc(CCN2CCCN(c3nc4ccccc4n3Cc3ccc(Cl)cc3)CCC2)cc1,,CCCCO,,,,val
US04590308,Cl.OCc1c(F)c(F)c(CO)c(F)c1F>>OCc1c(F)c(F)c(CCl)c(F)c1F,,Cc1ccccc1,,,,val
US20050245503A1,O=C(O)c1cnc(NNC(=S)NC2c3ccccc3CCc3ccccc32)c(Cl)c1.OCCNCc1ccccc1>>O=C(c1cnc(NNC(=S)NC2c3ccccc3CCc3ccccc32)c(Cl)c1)N(CCO)Cc1ccccc1,,CC(=O)N(C)C,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160176864A1,CS(=O)(=O)c1ccc2c(c1)[nH]c1cc(Br)cnc12.OC(c1ccccc1)C1CCC(F)(F)CC1>>CS(=O)(=O)c1ccc2c3ncc(Br)cc3n(C(c3ccccc3)C3CCC(F)(F)CC3)c2c1,,ClCCl,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06110924,CCCCCCCCCCBr.CCOC(=O)CC(=O)OCC>>CCCCCCCCCCC(C(=O)OCC)C(=O)OCC,,CCO,,[Na],,val
US20100160388A1,CSc1cc(NC(=O)N2C=CC(=O)CC2c2ccc(F)cc2)c(Br)cc1Cl.O=S([O-])OO>>CS(=O)(=O)c1cc(NC(=O)N2C=CC(=O)CC2c2ccc(F)cc2)c(Br)cc1Cl,,CC#N,CO,O,,val
US20140249126A1,CCn1cc(C(=O)O)c(=O)c2c(F)c(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)cc21.NCCN1CCCC1>>CCn1cc(C(=O)NCCN2CCCC2)c(=O)c2c(F)c(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)cc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20010056123A1,CCOC(=O)C1CCNCC1.Clc1cncc(Cl)c1Cl>>CCOC(=O)C1CCN(c2c(Cl)cncc2Cl)CC1,,Cc1ccccc1C,,CCN(CC)CC,CCOC(C)=O,val
US05710170,Brc1ccc(Br)cc1.O=C(C(F)(F)F)C(F)(F)F>>OC(c1ccc(Br)cc1)(C(F)(F)F)C(F)(F)F,,CCOCC,,[Li]CCCC,[Cl-].[NH4+],val
US20160096832A1,CC(C)(C)c1ccc(I)cc1.Cc1cc[nH]c(=O)c1N1CCc2nc(N)ncc2C1>>Cc1ccn(-c2ccc(C(C)(C)C)cc2)c(=O)c1N1CCc2nc(N)ncc2C1,[Cu]I,CN1CCCC1=O,,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20070185184A1,CC(=O)c1cn(-c2ccc([N+](=O)[O-])cc2Cl)c2ccc(Cl)cc12>>CC(=O)c1cn(-c2ccc(N)cc2Cl)c2ccc(Cl)cc12,[Pd],CO,,[H][H],,val
US20030202943A1,CCOC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O>>CCOC(=O)CN(CCN(CCN1CC(=O)OC(=O)C1)CC(=O)O)CC(=O)O,,CC(=O)OC(C)=O,,c1ccncc1,,val
US20070060618A1,C1CCOC1.Cc1nc(C#Cc2cncc(CO)c2)cs1>>COCc1cncc(C#Cc2csc(C)n2)c1,,C1CCOC1,Cc1ccccc1,CCCCCC,[H-].[Na+],val
US20080139595A1,N#Cc1c[nH]c2nccc(Oc3ccc(N)cc3F)c12.Nc1nccc(Cl)n1>>N#Cc1c[nH]c2nccc(Oc3ccc(Nc4ccnc(N)n4)cc3F)c12,,CCO,O,Cl,[Na+].[OH-],val
US20150210739A1,CC(C)(C)OC(=O)N1Cc2ccccc2[C@H]1C(=O)O.Nc1c(F)cccc1F>>CC(C)(C)OC(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F,,c1ccncc1,,O=P(Cl)(Cl)Cl,,val
US20060257987A1,CCc1ccc(O[C@H](C)CCOc2ccc(CCC(=O)OC)c(C)c2)c(C(C)(C)c2ccccc2)c1>>CCc1ccc(O[C@H](C)CCOc2ccc(CCC(=O)O)c(C)c2)c(C(C)(C)c2ccccc2)c1,,CO,O,Cl,[Na+].[OH-],val
US20020119992A1,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.COc1ccc(NC(c2ccc(Cl)cc2CN)C(F)F)cc1>>COc1ccc(NC(c2ccc(Cl)cc2CNC(=O)[C@@H]2CCCN2C(=O)OC(C)(C)C)C(F)F)cc1,,CN(C)C=O,,ClCCCl,On1nnc2cccnc21,val
US20150111891A1,CCOC(=O)C=O.Cc1cc(O)c2ccccc2c1C>>CCOC(=O)C(O)c1c(C)c(C)c2ccccc2c1O,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20100137299A1,O=C1C(=O)N(C(c2ccccc2)c2ccccc2)c2ccccc21.Oc1ccc2c(c1)CCCO2>>O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2C1(O)c1cc2c(cc1O)CCCO2,,C1CCOC1,ClCCl,CC(C)[Mg]Cl,[Cl-].[NH4+],val
US20110086834A1,COc1cc(Br)cc2c1CCN2.Nc1ncc(F)c(Cl)n1>>COc1cc(Br)cc2c1CCN2c1nc(N)ncc1F,,C1COCCO1,,,,val
US20140145119A1,CCCCC(CC)CO.O=C(O)c1cc2c(Br)[se]c(Br)c2s1>>CCCCCC(CC)OC(=O)c1cc2c(Br)[se]c(Br)c2s1,CN(C)c1ccncc1,,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20090069340A1,Cc1cc(=O)n(-c2ccc(Cl)cc2)n1C.O=C1CCC(=O)N1Cl>>Cc1c(Cl)c(=O)n(-c2ccc(Cl)cc2)n1C,,ClC(Cl)Cl,,,,val
US20150158865A1,CC(C)(C)OC(=O)N1CC[C@@H](Nc2nnc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)C1.Cl>>Cl.NC(=O)c1nnc(N[C@@H]2CCNC2)nc1Nc1ccc(C(=O)N2CCOCC2)cc1,,C1COCCO1,,,,val
US20030004161A1,CC(=O)Nc1ccc(Sc2nc(Nc3cc(C)n[nH]3)cc(-c3ccc(O)cc3)n2)cc1.CN(C)CCCCl>>CC(=O)Nc1ccc(Sc2nc(Nc3cc(C)n[nH]3)cc(-c3ccc(OCCCN(C)C)cc3)n2)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US06403610B1,COC(=O)[C@H]1CN(CC#Cc2cc(F)cc(F)c2)CC[C@H]1CCC(O)c1ccnc2ccc(OC)cc12>>COc1ccc2nccc(C(O)CC[C@@H]3CCN(CC#Cc4cc(F)cc(F)c4)C[C@@H]3C(=O)O)c2c1,,C1COCCO1,ClCCl,[Na+].[OH-],,val
US20020173665A1,O=Cc1cccc(O)c1.O=[N+]([O-])c1ccc(F)cc1>>O=Cc1cccc(Oc2ccc([N+](=O)[O-])cc2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06548499B1,CN(C)CCN.Clc1cc2nc(Cl)c(-c3ccccn3)nc2cc1Cl>>CN(C)CCNc1nc2cc(Cl)c(Cl)cc2nc1-c1ccccn1,,Cc1ccccc1,,,,val
US04259333,Cl.[N-]=[N+]=NCCCC1CCN(C=O)CC1>>Cl.NCCCC1CCN(C=O)CC1,[Pd],CCOC(C)=O,O,[H][H],,val
US20140235624A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(N)CO.N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-]>>CC(C)(COc1cccc([N+](=O)[O-])c1C#N)NC(=O)OC(C)(C)C,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[H-].[Na+],val
US20100075948A1,CC(C)(C)CC1NC(C(=O)NCCCN)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.NS(N)(=O)=O>>CC(C)(C)CC1NC(C(=O)NCCCNS(N)(=O)=O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04788206,NCCCCc1cccnc1.O=C(/C=C/C=C(c1ccccc1C(F)(F)F)c1ccccc1C(F)(F)F)Oc1ccc([N+](=O)[O-])cc1>>O=C(/C=C/C=C(c1ccccc1C(F)(F)F)c1ccccc1C(F)(F)F)NCCCCc1cccnc1,,C1CCOC1,ClCCl,,,val
US20150152096A1,CCOC(=O)C1CN(C)CCN1Cc1ccccc1>>CCOC(=O)C1CN(C)CCN1,[Pd],,,,,val
US20050282846A1,C[C@H](O)C/C=C/c1cccnc1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC(C)CC=Cc2cccnc2)cc1,,CCN(CC)CC,,O=C([O-])O.[Na+],,val
US20090118263A1,COC(=O)Cc1cccc(OCCN2CCOC3(CCNCC3)C2)c1.COCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(CCl)cc3)c2n1>>COCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(CN4CCC5(CC4)CN(CCOc4cccc(CC(=O)OC)c4)CCO5)cc3)c2n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060135522A1,C=CCBr.CC(=O)Nc1ccccc1-c1ccc2c(c1)Oc1ccccc1C2C1CCNCC1>>C=CCN1CCC(C2c3ccccc3Oc3cc(-c4ccccc4NC(C)=O)ccc32)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20030073709A1,CN(C)C=O.COc1c(-c2ccccc2)cc(C(=O)O)cc1-c1ccccc1.COc1c(C(C)C)cc(C(=O)O)cc1C(C)C.O=C(Cl)C(=O)Cl>>COc1c(C(C)C)cc(C(=O)c2c(Cc3ccc4ccccc4c3)oc(C)c2C)cc1C(C)C,CN(C)C=O,,,Cl[Sn](Cl)(Cl)Cl,,val
US20090137568A1,Brc1cc(C2OCCO2)sc1Br.CC(C)(C)[Si](C)(C)OCCCI>>OCCCc1sc(C2OCCO2)cc1Br,,C1CCOC1,,,,val
US05589478,CC(C)(C)c1ccc(S(=O)(=O)Nc2cc(OCCO)ncn2)cc1.O=C1CCC(=O)N1Br>>CC(C)(C)c1ccc(S(=O)(=O)Nc2ncnc(OCCO)c2Br)cc1,,CN(C)C=O,,O=S([O-])O.[Na+],,val
US05068334,COC(=O)Cn1c2c(ccc1=O)C(=O)CCC2>>O=C(O)Cn1c2c(ccc1=O)C(=O)CCC2,,[Na+],[OH-],,,val
US20070179164A1,COc1cccc(C=O)c1O.Cc1nc2ccccc2c(=O)n1-c1ccc(Cl)c(Cl)c1>>COc1cccc(C=Cc2nc3ccccc3c(=O)n2-c2ccc(Cl)c(Cl)c2)c1O,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20140350002A1,CI.CN1c2nc(C3CCN(C(=O)OC(C)(C)C)CC3O)ccc2N(CC2CC2(F)F)S1(=O)=O>>COC1CN(C(=O)OC(C)(C)C)CCC1c1ccc2c(n1)N(C)S(=O)(=O)N2CC1CC1(F)F,,CO,O,C1CCOC1,[H-].[Na+],val
US20120184542A1,COc1ncc2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1.NCc1ccc(Cl)cc1>>COc1ncc2cc(C(=O)Nc3cc(C(=O)NCc4ccc(Cl)cc4)ccc3Cl)c(=O)[nH]c2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050032786A1,COC(=O)c1ccccc1S.CSc1cc(CCC(=O)OC(C)(C)C)cc(C#N)n1>>CSc1cc(CCC(=O)OC(C)(C)C)cc(-c2nc(=O)c3ccccc3s2)n1,,Cc1ccccc1,,CCN(CC)CC,,val
US20100210452A1,CCOC(=O)C(=O)/C=C/c1ccc(C)cc1.O=CCCc1ccccc1Cl>>CCOC(=O)C1=C[C@H](c2ccc(C)cc2)[C@H](Cc2ccccc2)C(=O)O1,,ClC(Cl)Cl,,,,val
US20150329538A1,C/C=N/[S@@](=O)C(C)(C)C.Cc1ccc(S(=O)(=O)n2ccc(C(=O)OC(C)(C)C)c2)cc1>>Cc1ccc(S(=O)(=O)n2ccc(C(=O)OC(C)(C)C)c2[C@@H](C)N[S@@](=O)C(C)(C)C)cc1,,C1CCOC1,,,,val
US20040106667A1,Cc1nn(C(=O)OC(C)(C)C)c2ccc(NS(=O)(=O)c3ccccc3S(C)(=O)=O)cc12>>Cc1n[nH]c2ccc(NS(=O)(=O)c3ccccc3S(C)(=O)=O)cc12,,ClC(Cl)Cl,,C[Si](C)(C)I,,val
US20150045339A1,CC(C)(C)OC(=O)NCCCC#Cc1cnc(Nc2ccc(C#N)cc2)nc1Cl.c1cn[nH]c1>>CC(C)(C)OC(=O)NCCCC#Cc1cnc(Nc2ccc(C#N)cc2)nc1-n1cccn1,,CCOC(C)=O,CN1CCCC1=O,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070225292A1,CC(C)(C)OC(=O)Nc1ccc(C(=O)Nc2cccnc2C(=O)NCC2CCCCC2)c2ccccc12.O=C(O)C(F)(F)F>>Nc1ccc(C(=O)Nc2cccnc2C(=O)NCC2CCCCC2)c2ccccc12.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20120270838A1,CC(=O)OC(C)=O.Nc1ccc(CCS(=O)(=O)N2CCC3(CC2)N=C(C2CCCCC2)NC3=O)cc1>>CC(=O)Nc1ccc(CCS(=O)(=O)N2CCC3(CC2)N=C(C2CCCCC2)NC3=O)cc1,,ClCCl,ClCCl,CCN(CC)CC,,val
US20050153962A1,CCOC(=O)c1csc(Nc2ccc(OC)c(OC)c2)n1.O=C(Cl)c1ccccc1Cl>>CCOC(=O)c1csc(N(C(=O)c2ccccc2Cl)c2ccc(OC)c(OC)c2)n1,,ClCCl,,Br,CCN(CC)CC,val
US20100168122A1,O=CCCc1noc(Cc2ccccc2)n1>>OCCCc1noc(Cc2ccccc2)n1,,CO,,[BH4-].[Na+],,val
US20080146523A1,O=C(Nc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)c1ccccc1>>c1ccc(CNc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05470845,CCCc1ccc(O)cc1.OCCCCCCBr>>CCCc1ccc(OCCCCCCBr)cc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04411897,Br.CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)OCOC(=O)C(C)(C)C)=CCS[C@H]12)c1csc(N)n1>>Br.CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)OCOC(=O)C(C)(C)C)=CCS[C@H]12)c1csc(N)n1,,ClCCl,,CCOCC,,val
US20110301145A1,O=C(O)c1cc([N+](=O)[O-])n[nH]1>>O=[N+]([O-])c1cc(CO)[nH]n1,,C1CCOC1,,,,val
US04906669,CC(=CCc1ccc(O)cc1O)CCCC(C)CCCC(C)CCCC(C)C>>CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2ccc(O)cc2O1,,CO,,Cl,O,val
US05439917,BrCCc1ccccc1.Cc1c(CO)[nH]c2ncccc12>>Br.Cc1c2cccn(CCc3ccccc3)c-2nc1CO,,CC#N,,,,val
US05292760,CCCC(OC)(OC)OC.CNC(Cc1ccccc1N)c1sccc1C>>CCCC1=Nc2ccccc2CC(c2sccc2C)N1C,,CC(=O)O,,,,val
US05736534,CC1Cc2ccccc2N1.COc1cc2ncnc(Cl)c2cc1OC>>COc1cc2ncnc(N3c4ccccc4CC3C)c2cc1OC,,CC(C)O,,,,val
US04443607,O=C(CCl)NCCCn1cc(-c2ccccc2)c2ccccc2c1=O.O=C1NC(=O)c2ccccc21>>NCC(=O)NCCCn1cc(-c2ccccc2)c2ccccc2c1=O,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070219198A1,CC(C)(C)c1ccc(S(=O)(=O)C2CCNCC2)cc1.Fc1cccnc1Cl>>CC(C)(C)c1ccc(S(=O)(=O)C2CCN(c3ncccc3F)CC2)cc1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20020037907A1,CC(C)N.O=C(O)c1c(F)cccc1F>>CC(C)NC(=O)c1c(F)cccc1F,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20160102096A1,COC(=O)C(C)O[Si](C)(C)C(C)(C)C.NN>>CC(O[Si](C)(C)C(C)(C)C)C(=O)NN,,CCO,,,,val
US04921632,O=C(O)c1ccc(OCc2ccccc2)cc1>>O=C(O)c1ccc(O)cc1,[Pd],CCO,,,,val
US20150038488A1,CS(=O)(=O)OS(C)(=O)=O.C[C@@H](Oc1nc(-c2ccc(N3CCNCC3)cc2)cc2ncn(C(F)F)c12)[C@H]1CNC(=O)C1>>C[C@@H](Oc1nc(-c2ccc(N3CCN(S(C)(=O)=O)CC3)cc2)cc2ncn(C(F)F)c12)[C@H]1CNC(=O)C1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20050081313A1,CC1CNCC(C)C1.O=[N+]([O-])c1cnc(Cl)c([N+](=O)[O-])c1>>CC1CC(C)CN(c2ncc([N+](=O)[O-])cc2[N+](=O)[O-])C1,,C1CCOC1,,,,val
US20020035102A1,CC(C)(C)OC(=O)N1CCN(c2cccc(CS(=O)(=O)C=C3CN(C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)C3)c2)CC1>>O=S(=O)(C=C1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1)Cc1cccc(N2CCNCC2)c1,,O=CO,,,,val
US06071928,CI.Oc1ccc(OCc2ccccc2)cc1Br>>COc1ccc(OCc2ccccc2)cc1Br,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100249089A1,COc1ccc(/C(C#N)=C/c2ccc(N3CCC(OC(=O)CN4CCCCC4)CC3)s2)cc1OC.CS(=O)(=O)O>>COc1ccc(/C(C#N)=C/c2ccc(N3CCC(OC(=O)CN4CCCCC4)CC3)s2)cc1OC.CS(=O)(=O)O,,CO,,CC(C)O,,val
US20060014797A1,BrBr.CN(C)CCc1cc2ccccc2s1>>CN(C)CCc1sc2ccccc2c1Br,,ClC(Cl)Cl,,,,val
US05273986,Nc1cccc(/C=C/c2nc(C3CC3)cs2)c1.O=C1Cc2ccccc2C(=O)O1>>O=C(Cc1ccccc1C(=O)O)Nc1cccc(/C=C/c2nc(C3CC3)cs2)c1,,Cc1ccccc1,,,,val
US20020013460A1,CCNS(=O)(=O)c1ccc(-c2cc3ccccc3c(N3CCN(C=O)CC3)n2)cc1>>CCNS(=O)(=O)c1ccc(-c2cc3ccccc3c(N3CCNCC3)n2)cc1,,CCO,,[Na+].[OH-],,val
US20110189192A1,CCOC(=N)c1ccc(Br)s1.CNN>>CNNC(=N)c1ccc(Br)s1,,c1ccncc1,,,,val
US20050182072A1,CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)n1cccn1.CC(C)N1CC2CC1CN2>>CC(C)N1CC2CC1CN2C(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C,,CC#N,,CCN(C(C)C)C(C)C,,val
US20060178377A1,COc1ccccc1-c1cn2c(n1)NC(C)=C(C(N)=O)C2c1ccc(Cl)c(F)c1>>COc1ccccc1-c1cn2c(n1)NC(C)=C(C#N)C2c1ccc(Cl)c(F)c1,,ClCCl,,CCN(CC)CC,O=C(OC(=O)C(F)(F)F)C(F)(F)F,val
US20020161237A1,COC(=O)c1ccc(C(O)/C=C/c2cccc(O)c2)cc1Cl>>O=C(O)c1ccc(C(O)C=Cc2cccc(O)c2)cc1Cl,,C1CCOC1,CO,[Na+].[OH-],,val
US20110059951A1,CC(C)(C)OC(=O)N1CCNC(CO)C1.CI>>COCC1CN(C(=O)OC(C)(C)C)CCN1,,C1CCOC1,,[H-].[Na+],,val
US20060122064A1,CCOC(=O)CP(=O)(OCC)OCC.COc1cc(C(C)=O)ccc1OCc1ccccc1>>CCOC(=O)C=C(C)c1ccc(OCc2ccccc2)c(OC)c1,,O,,C1CCOC1,[H-].[Na+],val
US20040122244A1,BrCc1ccccc1.COc1c(C)c(Cc2cccc(O)c2C=O)c(OC)c(OC)c1OC>>COc1c(C)c(Cc2cccc(OCc3ccccc3)c2C=O)c(OC)c(OC)c1OC,,CC(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20100160660A1,Br[c-]1cccc1.Br[c-]1cccc1.ClP(Cl)c1ccccc1.PCl.[Fe+2]>>Br[c-]1cccc1.ClPc1ccc[c-]1-c1ccccc1.[Fe+2],,C1CCOC1,,[Li]CCCC,,val
US20110262359A1,CCOC(=O)N1CCN(C(=O)[C@H](CCCN/C(N)=N/S(=O)(=O)c2c(C)c(C)c3c(c2C)CC(C)(C)O3)NC(=O)OC(C)(C)C)CC1>>CCOC(=O)N1CCN(C(=O)[C@@H](N)CCCN/C(N)=N/S(=O)(=O)c2c(C)c(C)c3c(c2C)CC(C)(C)O3)CC1,,ClCCl,,C1COCCO1,Cl,val
US20160039745A1,COC(=O)C1(c2cccc(F)c2C)CCC(Oc2ccccc2)CC1>>Cc1c(F)cccc1C1(C(=O)O)CCC(Oc2ccccc2)CC1,,CO,,[Na+].[OH-],,val
US20110319403A1,COC(=O)C(C)(C)COc1ccc(NCCO[Si](C)(C)C(C)(C)C)cn1.O=C(Cl)c1c(Cl)ncnc1Cl>>COC(=O)C(C)(C)COc1ccc(N(CCO[Si](C)(C)C(C)(C)C)C(=O)c2c(Cl)ncnc2Cl)cn1,,C1CCOC1,,CCN(CC)CC,,val
US20080292608A1,CC(C)OB(OC(C)C)OC(C)C.CC(C)Oc1ncc(Br)cn1>>CC(C)Oc1ncc(B(O)O)cn1,,CCOCC,,[Li]CCCC,,val
US04990517,C=CCN(CC(C)(OC)OC)C(C)=O>>C=CCN(CC(C)=O)C(C)=O,,O=CO,,,,val
US20140249162A1,CC1(C)OB(c2ccc3c(c2Cl)CCCO3)OC1(C)C.COC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2[nH]c(C)c(C)c2c1Cl>>COC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2[nH]c(C)c(C)c2c1-c1ccc2c(c1Cl)CCCO2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140045821A1,O=C1NCCSc2c1sc1ccc(OCc3ccccc3)cc21>>O=C1NCCSc2c1sc1ccc(O)cc21,,ClCCl,,BrB(Br)Br,,val
US04610981,NCCCCn1ccnc1.O=S(=O)(Cl)c1ccc(Br)cc1>>O=S(=O)(NCCCCn1ccnc1)c1ccc(Br)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US20020002158A1,COC(=O)Cc1ccc(C(C)(C)C)cc1.ClCCBr>>COC(=O)C1(c2ccc(C(C)(C)C)cc2)CC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20140163031A1,CC1(C)CC(C(=O)O)CC(C)(C)O1.c1ccc2[nH]nnc2c1>>CC1(C)CC(C(=O)n2nnc3ccccc32)CC(C)(C)O1,,ClCCl,,O=S(Cl)Cl,,val
US20110152273A1,Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)cc3c2C(=O)NC3)c1.O=C1CCC(=O)N1I>>Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)c(I)c3c2C(=O)NC3)c1,,ClCCl,,,,val
US20090264648A1,BrCC1CC1.COC(=O)c1ccc(O)cc1C>>COC(=O)c1ccc(OCC2CC2)cc1C,,CC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20150166559A1,CCC1(O)C(=O)OCc2c1cc1n(c2=O)CCC1=O.COc1cc(C=O)c(N)cc1O>>CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3cc(OC)c(O)cc3nc2-1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20070254901A1,CCSc1ncc(CO)c(N)n1>>CCSc1ncc(C=O)c(N)n1,O=[Mn]=O,ClC(Cl)Cl,,,,val
US20130053366A1,Cc1ccc2c(c1)c1c(n2CC(OS(C)(=O)=O)c2ccncc2)CCN(C)C1.O=C(O)c1ccncc1>>Cc1ccc2c(c1)c1c(n2CC(OC(=O)c2ccncc2)c2ccncc2)CCN(C)C1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20050148656A1,CCOC(=O)[C@H](Cc1ccc(OCC(=O)N(Cc2ccc(CC)cc2)Cc2ccc(F)cc2F)cc1)OCC>>CCO[C@@H](Cc1ccc(OCC(=O)N(Cc2ccc(CC)cc2)Cc2ccc(F)cc2F)cc1)C(=O)O,,CC#N,,Cl,[Li+].[OH-],val
US20040157890A1,CCOC(=O)C(C)(C)Br.CCOC(=O)COc1ccc(S)cc1C>>CCOC(=O)COc1ccc(C(C)=O)cc1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06307056B1,Cc1ccc(B(O)O)cc1.O=C1Nc2cccc(I)c2/C1=C/c1ccc[nH]1>>Cc1ccc(-c2cccc3c2/C(=C/c2ccc[nH]2)C(=O)N3)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClC(Cl)Cl,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20090004185A1,CNC.O=C(Nc1ccc(CNc2nc(Cl)nc3ccccc23)cc1)c1ccc(F)cc1>>CN(C)c1nc(NCc2ccc(NC(=O)c3ccc(F)cc3)cc2)c2ccccc2n1,,C1CCOC1,,,,val
US20110275684A1,CC[C@H](N)C(N)=O.O=[N+]([O-])c1cc(Br)ccc1F>>CC[C@H](Nc1ccc(Br)cc1[N+](=O)[O-])C(N)=O,,C1CCOC1,CCN(CC)CC,Cl,,val
US20110003820A1,CNN.O=CC(=O)c1ccc(F)cc1F>>CNN=CC(=O)c1ccc(F)cc1F,,CO,,CC(=O)O,O,val
US20100075948A1,N#CCc1ccc(Cl)cc1.O=Cc1cccc(Cl)c1F>>N#C/C(=C\c1cccc(Cl)c1F)c1ccc(Cl)cc1,,CO,,C[O-].[Na+],,val
US20160257951A1,CCCCCCCCCCCCC(O)CCCCCCC/C=C\C[C@@H](CCCCCC)OC(C)=O.CN(C)CCCO.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCCCCCCCCCCC(CCCCCCC/C=C\C[C@@H](CCCCCC)OC(C)=O)OC(=O)OCCCN(C)C,,Cc1ccccc1,,c1ccncc1,,val
US04725620,CCCCOC(=O)COC(C)(C)C>>CC(C)(C)OCC(=O)O,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US05753635,CSc1nc(Cl)c([N+](=O)[O-])c(Oc2cc(C#N)ccc2OCc2ccccc2)n1.NCc1ccccc1>>CSc1nc(NCc2ccccc2)c([N+](=O)[O-])c(Oc2cc(C#N)ccc2OCc2ccccc2)n1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060276475A1,Cc1cc(CCl)no1.Nc1nc(N2CCCNCC2)nc2cc(-c3ccco3)nn12>>Cc1cc(CN2CCCN(c3nc(N)n4nc(-c5ccco5)cc4n3)CC2)no1,,CC#N,,CCN(CC)CC,,val
US05236952,CC(N)=NO.COc1cc(C(=O)n2ccnc2)cc([N+](=O)[O-])c1OC>>COc1cc(C(=O)ON=C(C)N)cc([N+](=O)[O-])c1OC,,CN(C)C=O,,,,val
US20100267688A1,O=C=O.c1csc(C2CCC3(CC2)OCCO3)n1>>O=C(O)c1cnc(C2CCC3(CC2)OCCO3)s1,,C1CCOC1,,[Li]CCCC,,val
US20090023747A1,O=C(OCc1ccccc1)N1C[C@H](F)[C@H]2OC[C@H](O)[C@H]21>>O=C1CO[C@@H]2[C@@H](F)CN(C(=O)OCc3ccccc3)[C@H]12,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05684041,CC(C)(C)c1cc(N)cc2c1OCC2(C)C.CN=C=O>>CNC(=O)Nc1cc(C(C)(C)C)c2c(c1)C(C)(C)CO2,,CCOCC,,,,val
US20110098275A1,C#Cc1ccc(N)nc1.CCc1nccc(Cl)c1I>>CCc1nccc(Cl)c1C#Cc1ccc(N)nc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,CCN(CC)CC,O,val
US20070249674A1,C=CC(=O)Nc1cc(C)c(I)cc1C.O=C(Nc1ccccc1-c1ccccc1)OC1CCNCC1>>Cc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(C)cc1I,,CC(C)O,,CN(C)C=O,,val
US20020040048A1,COc1ccc(S(=O)(=O)Cl)cc1.O=C(NNCc1ccccc1)[C@@H]1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)CN1S(=O)(=O)c1ccc2ccccc2c1>>COc1ccc(S(=O)(=O)N(Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](SC(c3ccccc3)(c3ccccc3)c3ccccc3)CN2S(=O)(=O)c2ccc3ccccc3c2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20160129023A1,CC(C)(C)[C@@H]1CC[C@@H](Oc2ccc3cc(C=O)ccc3c2)CC1.COC(=O)C(C)N>>COC(=O)C(C)NCc1ccc2cc(O[C@@H]3CC[C@@H](C(C)(C)C)CC3)ccc2c1,,CC(Cl)Cl,,CC(=O)O,[BH3-]C#N.[Na+],val
US06399643B1,O=C(Nc1ccccc1)Nc1ccc(CO)cc1.O=S(Cl)Cl>>O=C(Nc1ccccc1)Nc1ccc(CCl)cc1,,ClCCl,,,,val
US20100120841A1,CCOC(=O)Cc1cccc2c(F)cccc12>>O=C(O)Cc1cccc2c(F)cccc12,,CCO,,[Na+].[OH-],,val
US20110294854A1,FC(F)(F)c1cccc(Br)n1.O=C(Nc1cccc(F)c1)[C@H]1CC[C@@H]2CNC[C@H]12>>O=C(Nc1cccc(F)c1)[C@H]1CC[C@@H]2CN(c3cccc(C(F)(F)F)n3)C[C@H]12,,CCO,,CCN(CC)CC,,val
US20080188460A1,COc1ccc2nc(C)ccc2c1.O=[Se]>>COc1ccc2nc(C=O)ccc2c1,,C1COCCO1,O,,,val
US06069141,CC(=O)NCC1CC(c2ccc(F)c(F)c2)=NO1.O=Cc1cc[nH]c1>>CC(=O)NCC1CC(c2ccc(-n3ccc(C=O)c3)c(F)c2)=NO1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20120225888A1,COC(=O)C(OC(C)(C)C)c1c(C)nc2c(Br)c(-c3ccccc3)nn2c1Cl.Cc1c(B2OC(C)(C)C(C)(C)O2)cc(F)c2c1CCCO2>>COC(=O)C(OC(C)(C)C)c1c(C)nc2c(Br)c(-c3ccccc3)nn2c1-c1cc(F)c2c(c1C)CCCO2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060040917A1,COc1ccc(-c2coc3cc(OC)ccc3c2=O)cc1>>COc1ccc(C2COc3cc(OC)ccc3C2=O)cc1,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20080153828A1,COc1ccc2c(c1)ncn2C.O=C1CCC(=O)N1I>>COc1ccc2c(c1)nc(I)n2C,,C1CCOC1,C1CCOC1,[Li]C(C)(C)C,,val
US04735959,Cc1ccc(S(=O)(=O)NNC(=O)c2ccc(C(C(N)=O)C(C)c3ccccc3N3CCCCC3)cc2)cc1>>CC(c1ccccc1N1CCCCC1)C(C(N)=O)c1ccc(C=O)cc1,,OCCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20130137679A1,BrCc1cccc(Br)c1.Clc1cccc(N2CCNCC2)c1Cl>>Clc1cccc(N2CCN(Cc3cccc(Br)c3)CC2)c1Cl,,CC#N,O,CCN(CC)CC,Cl,val
US20140256734A1,CC(C)(C)OC(=O)N1CC[C@H](Nc2nc(C(=N)NN)cc3ccc(Cl)cc23)C1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)N1CC[C@H](Nc2nc(-c3n[nH]c(=O)[nH]3)cc3ccc(Cl)cc23)C1,,C1COCCO1,,,,val
US20100222318A1,CC(C)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3nnc(NC(=O)[C@@H]4CCCCN4C(=O)OCc4ccccc4)o3)n2)cc1>>CC(C)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3nnc(NC(=O)[C@@H]4CCCCN4)o3)n2)cc1,[Pd],CO,,CCOC(C)=O,,val
US20110028492A1,Fc1cc(-c2nc(NCC3CCOCC3)cnc2Cl)c(Cl)cn1.N[C@H]1CC[C@H](N)CC1>>N[C@@H]1CC[C@@H](Nc2cc(-c3nc(NCC4CCOCC4)cnc3Cl)c(Cl)cn2)CC1,,CS(C)=O,,,,val
US05741804,CCOC(=O)Cc1nc2ccc([N+](=O)[O-])cc2[nH]1>>CCOC(=O)Cc1nc2ccc(N)cc2[nH]1,[Pd],CCO,,,,val
US20040102436A1,Cc1ccc(S(=O)(=O)Cl)cc1.OCC1=Cc2cccc(OCc3ccccc3)c2CC1>>ClCC1=Cc2cccc(OCc3ccccc3)c2CC1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,O,val
US20160272602A1,O=C(C1CCN(c2cc(Cl)ccc2CN2CCNCC2)CC1)N1CCCC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OC(C(F)(F)F)C(F)(F)F>>O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Cl)cc2N2CCC(C(=O)N3CCCC3)CC2)CC1,,ClCCl,O,CCN(C(C)C)C(C)C,,val
US04485107,CN1CCC(C(O)(c2ccc(F)cc2)c2cccnc2)CC1>>CN1CCC(=C(c2ccc(F)cc2)c2cccnc2)CC1,,O,,Br,,val
US20030199458A1,CCC(=O)n1c(=O)oc2ccccc21.O=CCCCl>>C[C@H](C(=O)n1c(=O)oc2ccccc21)[C@H](O)CCCl,Cl[Ti](Cl)(Cl)Cl,ClCCl,,CCN(CC)CC,,val
US20010051645A1,COc1ccc(Oc2c(Cl)cc(C=C3SC(=O)NC3=O)cc2Cl)cc1C(C)C>>CC(C)c1cc(Oc2c(Cl)cc(C=C3SC(=O)NC3=O)cc2Cl)ccc1O,,ClCCl,,BrB(Br)Br,,val
US04092321,Clc1ccc(Sc2ccccc2)cn1.O=C(OO)c1cccc(Cl)c1>>O=S(c1ccccc1)c1ccc(Cl)nc1,,ClCCl,,,,val
US20150018542A1,COC(=O)c1cc(F)cc2cc(-c3ccc(CN(C)C)cc3)oc12.O=C1CCC(=O)N1Cl>>COC(=O)c1cc(F)cc2c(Cl)c(-c3ccc(CN(C)C)cc3)oc12,,C1CCOC1,,CCOC(C)=O,,val
US20050070506A1,CCOP(=O)(OCC)C1CCN(Cc2ccccc2)C1>>CCOP(=O)(OCC)C1CCNC1,[Pd],CO,,O=C[O-].[NH4+],,val
US20080021032A1,CC(O)Cn1ccc(N)n1.CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(CC(=O)O)n2)cc1Cl>>CC(O)Cn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)n1,,CO,ClCCl,Cc1cccc(C)n1,O=C(Cl)C(=O)Cl,val
US20030055265A1,CCOC(=O)C(Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)c2ccccc12)Nc1ccccc1C(=O)c1ccccc1>>Cc1oc(-c2ccccc2)nc1CCOc1ccc(CC(Nc2ccccc2C(=O)c2ccccc2)C(=O)O)c2ccccc12,,C1CCOC1,CCO,[Na+].[OH-],,val
US20120184508A1,C[Si](C)(C)CCOCn1nc(-c2cccc(Br)n2)c2cnc(Cl)nc21.NCCN1CCCCC1>>C[Si](C)(C)CCOCn1nc(-c2cccc(Br)n2)c2cnc(NCCN3CCCCC3)nc21,,CC(C)O,,,,val
US20150239842A1,C1COCCO1.CC(C)I.Cc1c(O)cccc1C(=O)O>>Cc1c(OC(C)C)cccc1C(=O)OC(C)C,,O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080200461A1,COc1cc2c(=O)n(CCCO)c(SCc3cc(C)cc(C)c3)nc2c(OC)c1OC.CS(=O)(=O)Cl>>COc1cc2c(=O)n(CCCOS(C)(=O)=O)c(SCc3cc(C)cc(C)c3)nc2c(OC)c1OC,,ClCCl,,CCN(CC)CC,O,val
US20020103247A1,BrCCCCBr.CC(C)(C)OC(=O)n1ccc2cc(O)ccc21>>CC(C)(C)OC(=O)n1ccc2cc(OCCCCBr)ccc21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160137637A1,Nc1ncn[nH]1.O=C(O)c1csc(-c2ccc3c(c2)CCO3)n1.c1ccncc1>>O=C(Nc1nc(-c2cccnc2)n[nH]1)c1csc(-c2ccc3c(c2)CCO3)n1,,c1ccncc1,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20160168156A1,COCCN.O=C(O)/C=C/c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12>>COCCNC(=O)/C=C/c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150031708A1,COc1cc(B2OC(C)(C)C(C)(C)O2)ccn1.Cc1cc(Cl)nc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)c1>>COc1cc(-c2cc(C)cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)n2)ccn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,ClCCl,O=C([O-])[O-].[Na+].[Na+],,val
US20020169317A1,N#CCBr.Oc1cccc2c1c1cccc3c1n2[C@H](c1ccccc1)CO3>>N#CCOc1cccc2c1c1cccc3c1n2[C@H](c1ccccc1)CO3,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100113462A1,CCOC(=O)C1(NC(=O)c2cccc(C)c2C=C(C)C)Cc2ccc(Cl)cc2C1>>CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(Cl)cc2C1,,CCO,,[K+].[OH-],,val
US20010039286A1,CN(C)C1(C#N)CCN(Cc2ccccc2)CC1.Cl[Mg]Cc1ccccc1>>CN(C)C1(Cc2ccccc2)CCN(Cc2ccccc2)CC1,,CCOCC,,Cl,,val
US20160251339A1,C=O.COc1c(N2CCNCC2)cc(S(=O)(=O)n2cc(C)c3ccc(Br)cc32)c2ccccc12>>COc1c(N2CCN(C)CC2)cc(S(=O)(=O)n2cc(C)c3ccc(Br)cc32)c2ccccc12,,CO,,[BH3-]C#N.[Na+],,val
US20080207659A1,COc1ccc(-c2ccnc(-n3c(=O)n(C(=O)OC(C)(C)C)c4ccccc43)n2)cc1OC1CCCC1>>COc1ccc(-c2ccnc(-n3c(=O)[nH]c4ccccc43)n2)cc1OC1CCCC1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20140179666A1,COC[C@H]1CN(C(=O)OC(C)(C)C)[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(C3=CCCC3)cc21>>COC[C@H]1CN(C(=O)OC(C)(C)C)[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(C3CCCC3)cc21,[Pd],C1CCOC1,CO,,,val
US20110028492A1,Fc1cccc(CNc2nc(-c3cc(F)ncc3Cl)ccc2F)c1.N[C@H]1CC[C@H](N)CC1>>N[C@@H]1CC[C@@H](Nc2cc(-c3ccc(F)c(NCc4cccc(F)c4)n3)c(Cl)cn2)CC1,,CS(C)=O,,,,val
US04931083,CC(Oc1ncn(-c2ccccc2)n1)C(=O)O.O=S(Cl)Cl>>CC(Oc1ncn(-c2ccccc2)n1)C(=O)Cl,,Cc1ccccc1,,,,val
US20070027178A1,Cl.Nc1cc([N+](=O)[O-])ccc1SCCCCl.O=N[O-]>>Cl.NNc1cc([N+](=O)[O-])ccc1SCCCCl,,O,,Cl[Sn]Cl,,val
US20040116461A1,CN(C)CCCN.O=C(O)c1ccc(-n2nc3c4ccccc4scc-3c2=O)cc1>>CN(C)CCCNC(=O)c1ccc(-n2nc3c4ccccc4scc-3c2=O)cc1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120010183A1,CC(C)(C)OC(=O)C1CC(F)(F)C1.Fc1ncccc1Cl>>CC(C)(C)OC(=O)C1(c2ncccc2Cl)CC(F)(F)C1,,Cc1ccccc1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US06172100B2,COC(=O)CCCOc1ccc(-c2cc3ccccc3n2Cc2ccc(CN3CCCC3)c(OC)c2)cc1.O=C([O-])C(=O)[O-]>>COc1cc(Cn2c(-c3ccc(OCCCCO)cc3)cc3ccccc32)ccc1CN1CCCC1.O=C(O)C(=O)O,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04920116,CCCS(=O)(=O)Cl.CCOC(=O)c1ccc(N)cc1>>CCCS(=O)(=O)Nc1ccc(C(=O)O)cc1,,c1ccncc1,,,,val
US20100143249A1,O=C(O)CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O>>N[C@@H](CCC(=O)O)C(=O)O,,CO,ClCCl,,,val
US20120214837A1,CCN.COc1ccc2nc(Cl)c(C=O)cc2c1>>CCNc1nc2ccc(OC)cc2cc1C=O,,C1CCOC1,,,,val
US20100204196A1,COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2cccc3c2C(=O)NC3)c2ccn(S(=O)(=O)c3ccc(C)cc3)c2n1>>COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2cccc3c2C(=O)NC3)c2ccnc-2[nH]1,,C1COCCO1,,[K+].[OH-],,val
US20140235612A1,CCOC(=O)C(=O)Nc1cccnc1NC1CCCC1>>CCOC(=O)c1nc2cccnc2n1C1CCCC1,,Cc1ccccc1,,,,val
US20140288326A1,C=C(C)C1CCCCCCC1=O.CC=NOCC>>CCON1C(=O)CCCCCCC=C(C)CC1C,,ClCCCl,,Cl[Sn](Cl)(Cl)Cl,,val
US20140088100A1,CN1CCC(N)CC1.Cc1cnc(Nc2ccc(C(=O)O)cc2[N+](=O)[O-])nc1N1CCN(C(=O)OC(C)(C)C)CC1>>Cc1cnc(Nc2ccc(C(=O)NC3CCN(C)CC3)cc2[N+](=O)[O-])nc1N1CCN(C(=O)OC(C)(C)C)CC1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140343278A1,Cn1c(=O)ccc2cc(OCCN)ccc21.O=Cc1cccnc1>>Cn1c(=O)ccc2cc(OCCNCc3cccnc3)ccc21,,CO,O,[BH4-].[Na+],,val
US20050272931A1,Ic1ccnc(Nc2ccc3c(c2)OCCO3)c1.OB(O)c1cccc(C(F)(F)F)c1>>FC(F)(F)c1cccc(-c2ccnc(Nc3ccc4c(c3)OCCO4)c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,,,val
US20120135990A1,CC(C(=O)NC(C(=O)N1CCC2NCC(Oc3ccc(F)c(F)c3)C21)C(C)(C)C)N(C)C(=O)OCc1ccccc1.CN=C=O>>CNC(=O)N1CC(Oc2ccc(F)c(F)c2)C2C1CCN2C(=O)C(NC(=O)C(C)N(C)C(=O)OCc1ccccc1)C(C)(C)C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05271864,CCCCCC1=CCC(C(=O)OCC)CC1>>CCCCCC1=CCC(C(=O)O)CC1,,O,,Cl,[K+].[OH-],val
US04254123,CCOC(=O)C(=O)CBr.Nc1nc2ccccc2nc1Cl>>CCOC(=O)C(=O)C[n+]1c(N)c(Cl)nc2ccccc21.[Br-],,COCCOC,,,,val
US03962274,Cl.[N-]=[N+]=NCCn1cncc1[N+](=O)[O-]>>Cl.[N-]=[N+]=NCCn1cncc1[N+](=O)[O-],,CC(C)O,,,,val
US20120208828A1,Cc1ccc(-c2nnc(CCl)o2)cc1.Sc1nnc(-c2ccc(Cl)c(Cl)c2)n1-c1ccccc1Cl>>Cc1ccc(-c2nnc(CSc3nnc(-c4ccc(Cl)c(Cl)c4)n3-c3ccccc3Cl)o2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130090469A1,CC(C)CCOc1cccc(OCCC(C)C)c1-c1c2nc(cc3ccc([nH]3)c(-c3c(OCCC(C)C)cccc3OCCC(C)C)c3nc(cc4ccc1[nH]4)C=C3)C=C2.O=C1CCC(=O)N1Br>>CC(C)CCOc1cccc(OCCC(C)C)c1-c1c2nc(c(Br)c3ccc([nH]3)c(-c3c(OCCC(C)C)cccc3OCCC(C)C)c3nc(cc4ccc1[nH]4)C=C3)C=C2,,ClCCl,,O=C1CCC(=O)N1Br,,val
US06803380B1,COc1ccc(-n2nc(C(F)(F)F)nc2-c2ccc(S(C)(=O)=O)cc2)cc1>>CS(=O)(=O)c1ccc(-c2nc(C(F)(F)F)nn2-c2ccc(O)cc2)cc1,,O,,Br,CC(=O)O,val
US20100094000A1,CC1(C)OB(c2ccc3c(c2)NC(=O)CO3)OC1(C)C.Cc1nn(CC2CCC(O)CC2)c(-c2ccc(F)cc2)c1Br>>Cc1nn(C[C@@H]2CC[C@H](O)CC2)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2,,C1CCOC1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140200227A1,CC(C)(C)OC(=O)Nc1sc(-c2c(F)cccc2F)nc1C(=O)O.C[C@@H]1C[C@H](NC(=O)OC(C)(C)C)CN(c2c(N)cnc3c2CCO3)C1>>C[C@@H]1C[C@H](N)CN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnc3c2CCO3)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100009986A1,CCCCC1(N(C)C)CCC(c2[nH]c3ccccc3c2CCCCOC(C)=O)CC1.C[Si](C)(C)Cl>>CCCCC1(N(C)C)CCC(c2[nH]c3ccccc3c2CCCCOC(C)=O)CC1.Cl,,CCOC(C)=O,,,,val
US20050153957A1,NCc1ccccc1.O=C1CCc2ccccc2CC1>>c1ccc(CNC2CCc3ccccc3CC2)cc1,[Pd],CCO,,,,val
US20100331381A1,CC(C)(C)c1cc(C#N)[nH]n1.O=S(=O)(Cl)c1ccccc1>>CC(C)(C)c1cc(CN)n(S(=O)(=O)c2ccccc2)n1,,ClCCl,,CCCCCC,CCOC(C)=O,val
US06130187,CI.CNC(C)c1cc2c(Cl)cc(F)c(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c2o1>>CC(c1cc2c(Cl)cc(F)c(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c2o1)N(C)C,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080194552A1,C#Cc1cnc(N)nc1.NCc1cccc(I)c1>>NCc1cccc(C#Cc2cnc(N)nc2)c1,I[Cu]I,CN(C)C=O,,CCN(CC)CC,,val
US20060100207A1,C=CCOC(=O)C(C(C)=O)C(CC(=O)Nc1cccc(C(F)(F)F)c1)c1ccc(C#N)cc1>>C=CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)CC1c1ccc(C#N)cc1,,CCO,,O=S(=O)([O-])[O-].[Mg+2],,val
US20090143371A1,CC(=O)Cl.Cc1onc(-c2ccccc2)c1COc1ccc(N)cn1>>CC(=O)Nc1ccc(OCc2c(-c3ccccc3)noc2C)nc1,,C1CCOC1,,CCN(CC)CC,,val
US20050049236A1,COc1cc(OC)c(/C=C/C(=O)c2ccc(S(=O)(=O)NCC(=O)O)cc2)cc1C#Cc1ccccc1N>>COc1cc(OC)c(-c2cc3ccccc3[nH]2)cc1/C=C/C(=O)c1ccc(S(=O)(=O)NCC(=O)O)cc1,Cl[Pd]Cl,CC#N,CCO,,,val
US20020173527A1,CN(C)C=O.COc1ccc(Cn2cc(C)c3ccc(C(=O)N(C)OC)cc32)cc1>>Cc1cncc(C)c1C=O,,CCOCC,,[Li]CCCC,[Cl-].[NH4+],val
US20060094767A1,CC(C)(C)OC(=O)N1CCN(CC2(C)Cn3cc([N+](=O)[O-])nc3O2)CC1.Clc1nc2ccccc2o1>>CC1(CN2CCN(c3nc4ccccc4o3)CC2)Cn2cc([N+](=O)[O-])nc2O1,,O=C(O)C(F)(F)F,,CCN(CC)CC,O,val
US20120252805A1,CI.COc1cccc(-c2c(C)sc3[nH]c(=O)cc(N)c23)c1>>COc1cccc(-c2c(C)sc3nc(OC)cc(N)c23)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04569996,COc1cccnc1CCCCNc1nc(=O)cc[nH]1.Cc1ccc(C=O)cn1>>COc1cccnc1CCCCNc1nc(=O)c(C(O)c2ccc(C)nc2)c[nH]1,,Cl,,[Na+].[OH-],,val
US20070054942A1,N=C(c1ccncc1)c1cc(F)c(Br)cc1F.NO>>ON=C(c1ccncc1)c1cc(F)c(Br)cc1F,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20150018343A1,CC(C)(C)OC(=O)N1CC(O)C1.O=Cc1ccc(F)cc1F>>CC(C)(C)OC(=O)N1CC(Oc2cc(F)ccc2C=O)C1,,C1COCCO1,O,CC(C)(C)O[K],,val
US20140128383A1,COC(=O)C(OC(C)(C)C)c1cc(-c2ccccc2)sc1-c1ccc2c(c1)CCCO2>>CC(C)(C)OC(C(=O)O)c1cc(-c2ccccc2)sc1-c1ccc2c(c1)CCCO2,,CCO,O,[K+].[OH-],,val
US20080166359A1,CC(C)(C)OC(=O)NCC1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1.CI>>COC1(CNC(=O)OC(C)(C)C)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1,O=[Ag-],CCOCC,,,,val
US20140162985A1,BrCc1ccccc1.N#C[C@@]12CC[C@](O)(C(F)(F)F)C[C@H]1CCCc1cc3c(cnn3-c3ccc(F)cc3)cc12>>N#C[C@@]12CC[C@](OCc3ccccc3)(C(F)(F)F)C[C@H]1CCCc1cc3c(cnn3-c3ccc(F)cc3)cc12,,CN(C)C=O,,[H-].[Na+],,val
US05840732,CCCC=O.O=C1CSC(=O)N1CCCCOc1cccc2nccn12>>CCCC=C1SC(=O)N(CCCCOc2cccc3nccn23)C1=O,,CCO,,C1CCNCC1,,val
US04767766,COCCl.Oc1c(-c2ccccc2)sc2ncccc12>>COCOc1c(-c2ccccc2)sc2ncccc12,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20100130738A1,COC(=O)C(C)(C)C(=O)c1ccc(OC)c2nc(C(C)C)ccc12.NN>>COc1ccc(C2=NNC(=O)C2(C)C)c2ccc(C(C)C)nc12,,CCO,,O,,val
US20090311217A1,COc1ccc2[nH]c(C)c(C=O)c2c1.ClCCBr>>COc1ccc2c(c1)c(C=O)c(C)n2CCCl,,CN(C)C=O,,[H-].[Na+],,val
US20100093757A1,Cc1ccc(NC(=O)[C@H](CO[C@H](C)CO[Si](C(C)C)(C(C)C)C(C)C)Oc2ncnc3c2cnn3-c2c(Cl)cccc2C#N)nc1>>Cc1ccc(NC(=O)[C@H](CO[C@H](C)CO)Oc2ncnc3c2cnn3-c2c(Cl)cccc2C#N)nc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20020037891A1,CCOC(=O)c1cn(C)c2nc3cc(F)c(F)cc3cc2c1=O.Fc1ccc(N2CCNCC2)cc1>>CCOC(=O)c1cn(C)c2nc3cc(N4CCN(c5ccc(F)cc5)CC4)c(F)cc3cc2c1=O,,CS(C)=O,,CCN(CC)CC,,val
US20030119811A1,CC(C)(C)OC(=O)Nc1ncc(C(=O)O)cn1.Cc1ccc(CCS(=O)(=O)N2CCC(CN)CC2)cc1>>Cc1ccc(CCS(=O)(=O)N2CCC(CNC(=O)c3cnc(N)nc3)CC2)cc1,,C1COCCO1,,Cl,,val
US20150166549A1,CCCc1oc(=O)c2ccccc2c1-c1ccccc1.O=C1CCC(=O)N1Br>>CCC(Br)c1oc(=O)c2ccccc2c1-c1ccccc1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20090069288A1,CC(C)Oc1ccc(N)cc1Cl.CC1(C)OC[C@H](COc2ccc(-c3cc(C(=O)O)no3)cc2)O1>>CC(C)Oc1ccc(NC(=O)c2cc(-c3ccc(OC[C@H]4COC(C)(C)O4)cc3)on2)cc1Cl,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,O=C(Cl)C(=O)Cl,val
US05928841,C=C(C)C(=O)OC(C)(C)C.C=C(C)C(=O)Oc1ccc2ccccc2c1>>C=C(C)C(=O)OC(C)(C)C.C=C(C)C(=O)Oc1cccc2ccccc12,,Cc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US04536508,CCOC(=O)CCCOc1cccc(CN2CCCCC2)c1>>O=C(O)CCCOc1cccc(CN2CCCCC2)c1,,CCO,O,Cl,[K+].[OH-],val
US20070299120A1,COc1ccc(CCNC(C#N)c2ccc(OC)cc2)cc1>>COc1ccc(CCNC(CN)c2ccc(OC)cc2)cc1,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05348677,CCCCCCCc1cnc(-c2ccc(C=CC(=O)OCC(F)(F)C(F)F)cc2)nc1>>CCCCCCCc1cnc(-c2ccc(CCC(=O)OCC(F)(F)C(F)F)cc2)nc1,[Pd],C1CCOC1,,,,val
US20090270359A1,Cc1nn(Cc2ccc(S(=O)(=O)Oc3ccccc3)cc2)c(C)c1-c1ccc(C#N)c(Cl)c1>>Cc1nn(Cc2ccc(S(=O)(=O)O)cc2)c(C)c1-c1ccc(C#N)c(Cl)c1,,CO,,[Na+].[OH-],,val
US20050143407A1,CC(C)(C)OC(=O)N[C@@H]1CNCC12CC2.CCOC(=O)c1cc(F)c(F)c(OC)c1F>>CCOC(=O)c1cc(F)c(N2C[C@@H](NC(=O)OC(C)(C)C)C3(CC3)C2)c(OC)c1F,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US03965100,COC(=O)C1CCCC1=O.Cc1ccnc(N)c1C>>Cc1ccn2c(=O)c3c(nc2c1C)CCC3,,COCCO,,,,val
US05808062,COc1ccc(C(C)=O)cc1C.O=C(O)C(SCc1ccccc1)C(=O)O>>COc1ccc(-c2cc(O)c(SCc3ccccc3)c(=O)o2)cc1C,,CCOCC,,[Br-].[K+],,val
US20140088124A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)c1cccc(OCC2CCN(c3ccc(Br)cn3)CC2)c1>>COC(=O)c1cccc(OCC2CCN(c3ccc(B(O)O)cn3)CC2)c1,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20130137675A1,Ic1ccnn1-c1ccccc1.O=c1ccc(-c2cccc(C(F)(F)F)c2)n[nH]1>>O=c1ccc(-c2cccc(C(F)(F)F)c2)nn1-c1ccnn1-c1ccccc1,[Cu],c1ccncc1,,Cl,O=C([O-])[O-].[K+].[K+],val
US20050245522A1,C1COCCN1.COc1ccccc1C(C#N)NC(=O)[C@@H]1CCCC[C@H]1C(=O)O>>COc1ccccc1C(C#N)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCOCC1,,C1CCOC1,,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US20150306232A1,COc1ccc2cc([C@H](C)C(=O)O)ccc2c1.O=C1CCC(=O)N1O>>COc1ccc2cc([C@H](C)C(=O)O)ccc2c1.O=C1CCC(=O)N1O,,ClC(Cl)Cl,,CC(C)N=C=NC(C)C,,val
US20060148805A1,CCNc1nccs1.COc1ccc2c(c1)nc(C(=O)C(C)(C)C)n2CC(=O)O>>CCN(C(=O)Cn1c(C(=O)C(C)(C)C)nc2cc(OC)ccc21)c1nccs1,,CN(C)C=O,ClCCCl,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US06713471B1,CCOc1ccc(Br)c(Cl)c1.COB(OC)OC>>CCOc1ccc(B(O)O)c(Cl)c1,,C1CCOC1,,Cl,[Li]CCCC,val
US06350749B1,Cl.N=C(N)NN.O=C1CC(c2ccc(F)cc2)Cc2occ(C(F)(F)F)c21>>Cl.N=C(N)N/N=C1\CC(c2ccc(F)cc2)Cc2occ(C(F)(F)F)c21,,CCO,,Cl,,val
US20150087600A1,COC(=O)Cl.O=C(O)[C@@H]1CCCN1>>COC(=O)N1CCC[C@H]1C(=O)O,,C1CCOC1,,O=C([O-])O.[Na+],,val
US05219873,BrCc1ccccc1.CCC(=NO)c1cccnc1>>CCC(=NO)C1=CC=CN(Cc2ccccc2)C1.[Br-],,CCOC(C)=O,,,,val
US05145843,Clc1ccc2c(Cl)ccnc2c1.Nc1ccc(F)cc1>>Fc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1,,CCOC(C)=O,,,,val
US20080113966A1,NN.O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CNC1=S)N1CCC(n2c(=O)[nH]c3ncccc32)CC1>>NN=C1NC[C@H](c2cccc(F)c2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1,,CO,,O,,val
US05446042,COc1ccc(C(=O)CBr)cc1.O=C1CCC(c2ccncc2)=NN1>>COc1ccc(C(=O)C[n+]2ccc(C3=NNC(=O)CC3)cc2)cc1.[Br-],,CCO,,,,val
US05506259,CCOC(=O)c1cc(NC(=O)C(CSC(C)=O)Cc2cccc(OC)c2)c[nH]1>>COc1cccc(CC(CS)C(=O)Nc2c[nH]c(C(=O)O)c2)c1,,CCOC(C)=O,,,,val
US20140114068A1,CCNC(=O)NC12C(=O)c3c([N+](=O)[O-])cccc3C1(O)Oc1cc(C(C)C)ccc12>>CCNC(=O)NC12C(=O)c3c(N)cccc3C1(O)Oc1cc(C(C)C)ccc12,[Fe],CCO,,Cl,O,val
US05346917,CCN(CC)CCNc1ccc(C=O)c2sc3ccccc3c(=O)c12.O=CNc1ccccc1>>CCN(CC)CCNc1ccc(CN(C=O)c2ccccc2)c2sc3ccccc3c(=O)c12,,O,,O=CO,,val
US20110098429A1,CC(C)(C)c1cccc(C(=O)c2ccccc2)c1OCc1ccccc1.COc1ccccc1-c1cccc(Br)c1>>COc1ccccc1-c1cccc(C(O)(c2ccccc2)c2cccc(C(C)(C)C)c2OCc2ccccc2)c1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20110081409A1,C1COCCN1.COC(=O)c1ccc2ccn(CCOc3ccccc3C=O)c2c1>>COC(=O)c1ccc2ccn(CCOc3ccccc3CN3CCOCC3)c2c1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20030114666A1,NC(=O)c1ccc(F)c(OC(F)F)c1F.NC1CC1.O=C(Cl)C(=O)Cl>>O=C(NC(=O)c1ccc(F)c(OC(F)F)c1F)NC1CC1,,C1COCCO1,O,ClCCCl,,val
US20090270460A1,Cl.Nc1ccccc1OC(F)(F)F.O=N[O-]>>Cl.NNc1ccccc1OC(F)(F)F,,O,,Cl[Sn]Cl,,val
US20160159814A1,C[C@H](O)c1cccc2c1C(F)(F)C(=O)N2Cc1nn(C(=O)OC(C)(C)C)c2ccccc12>>C[C@H](O)c1cccc2c1C(F)(F)C(=O)N2Cc1n[nH]c2ccccc12,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US04560692,CNC(=O)C1CCNCC1.Fc1ccc(-c2cc(Cl)c3cc(Cl)ccc3n2)cc1>>CNC(=O)C1CCN(c2cc(-c3ccc(F)cc3)nc3ccc(Cl)cc23)CC1,,O,c1ccncc1,,,val
US20110312945A1,CCOC(=O)Cn1c(C)c(Sc2ccccc2)c2c1CC(C)(C)CC2=O.O=S(=O)(O)Cl>>CCOC(=O)Cn1c(C)c(Sc2ccc(S(=O)(=O)Cl)cc2)c2c1CC(C)(C)CC2=O,,ClCCl,,CCOC(C)=O,,val
US04705795,CC1CCCNC1.N#CCCCCl>>CC1CCCN(CCCC#N)C1,,c1ccccc1,,,,val
US04933355,CCOC(=O)C(=O)c1csc(N)n1.S=C=Nc1ccc(Cl)cc1>>CCOC(=O)C(=O)c1csc(NC(=S)Nc2ccc(Cl)cc2)n1,,CN(C)P(=O)(N(C)C)N(C)C,,,,val
US20080275097A1,CC(=O)Oc1cccc2ncccc12>>CC(=O)Oc1cccc2c1CCCN2,O=[Pt]=O,CCO,,Cl,,val
US20110118236A1,CSc1sc(C(=O)NCCn2nc(C(F)(F)F)c3c2CCCC3)c2c1C(=O)CCC2>>CSc1sc(C(=O)NCCn2nc(C(F)(F)F)c3c2CCCC3)c2c1C(O)CCC2,,CO,,O,[BH4-].[Na+],val
US20120225866A1,CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCn3cc(-c4ccc(OC)nc4)c(=O)c4ccccc43)ccc21.CS(=O)(=O)O>>CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCn3cc(-c4ccc(OC)nc4)c(=O)c4ccccc43)ccc21.CS(=O)(=O)O,,CC(C)O,CCOC(C)=O,,,val
US20040029850A1,C[C@H]1COc2c(C#N)cccc2C(=O)N(C[C@@H](CCOS(C)(=O)=O)c2ccc(Cl)c(Cl)c2)C1.[N-]=[N+]=[N-]>>C[C@H]1COc2c(C#N)cccc2C(=O)N(C[C@@H](CCN=[N+]=[N-])c2ccc(Cl)c(Cl)c2)C1,,CN(C)C=O,,O,,val
US20030225053A1,COc1c(N)cc(C(C)(C)C)cc1NS(C)(=O)=O.O=C(Nc1cccc2cc(C(=O)O)sc12)c1ccc(Cl)nc1>>COc1c(NC(=O)c2cc3cccc(NC(=O)c4ccc(Cl)nc4)c3s2)cc(C(C)(C)C)cc1NS(C)(=O)=O,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20100010035A1,CCOC(=O)N=C(C)OCC.NNc1ccccc1>>Cc1nn(-c2ccccc2)c(=O)[nH]1,,Cc1ccccc1,,CCN(CC)CC,,val
US20030220364A1,CCOC(=O)c1cc(NCc2c(C)cccc2C)c2nc(C)c(C)n2c1>>Cc1cccc(C)c1CNc1cc(CO)cn2c(C)c(C)nc12,,C1CCOC1,,O,[Na+].[OH-],val
US20040167128A1,O=C1CCCc2ccc(NS(=O)(=O)c3ccc(F)cc3)c(C(=O)O)c21>>O=C(O)c1c(NS(=O)(=O)c2ccc(F)cc2)ccc2c1C(O)CCC2,,CO,,[BH4-].[Na+],,val
US05674468,CCCCCCCCCCOC(=O)OC(C)OC(=O)CCCCCCC(=O)OCc1ccccc1>>CCCCCCCCCCOC(=O)OC(C)OC(=O)CCCCCCC(=O)O,[Pd],CC(=O)O,,,,val
US20130288112A1,CC1CC[N+]2(CCCC2)C1.O=S(=O)(F)[N-]S(=O)(=O)F>>CC1CC[N+]2(CCCC2)C1.O=S(=O)(F)[N-]S(=O)(=O)F,,O,,[Br-].[K+],,val
US20060111419A1,Cc1ccc2[nH]nc3c2c1NC(=O)c1ccccc1-3.O=C1CCC(=O)N1Br>>Cc1cc(Br)c2[nH]nc3c2c1NC(=O)c1ccccc1-3,,CN(C)C=O,,CCOC(C)=O,,val
US05545669,O=C([O-])c1ccccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1>>O=C(O)c1ccccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070105904A1,Cc1ccnc(CCl)c1.Nc1ncccc1-c1cc(Cc2ccc(O)cc2)no1>>Cc1ccnc(COc2ccc(Cc3cc(-c4cccnc4N)on3)cc2)c1,,CN(C)C=O,,CO,[Na+].[OH-],val
US20130150362A1,CC1(C)OB(c2cnn(-c3ccccc3)c2)OC1(C)C.CCOC(=O)C1(CO)CCC(c2cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3ncc(I)c3n2)CC1>>CCOC(=O)C1(CO)CCC(c2cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3ncc(-c4cnn(-c5ccccc5)c4)c3n2)CC1,,C1COCCO1,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20050171087A1,CC(C)(C)OC(=O)NCC(=O)O.N[C@@H]1CCCN2c3cc(Cl)ccc3Oc3ccccc3[C@H]12>>CC(C)(C)OC(=O)NCC(=O)N[C@@H]1CCCN2c3cc(Cl)ccc3Oc3ccccc3[C@H]12,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120135977A1,CC(C)(C)Cn1nnc2cc([N+](=O)[O-])ccc21>>CC(C)(C)Cn1nnc2cc(N)ccc21,[Pd],CCO,,,,val
US05382585,COCCN.COc1ncnc2no[n+]([O-])c12>>COCCNc1ncnc2no[n+]([O-])c12,,CO,,,,val
US20040067202A1,Cc1ccc(S(=O)(=O)OCCOCCOCCOCCOCCOCCOCc2ccccc2)cc1.OCC(F)(F)F>>FC(F)(F)COCCOCCOCCOCCOCCOCCOCc1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20130296375A1,COC(=O)C1CN1C(=O)OCc1ccccc1.OC[C@H](OCc1ccccc1)[C@H](CO)OCc1ccccc1>>COC(=O)[C@H](COC[C@H](OCc1ccccc1)[C@H](CO)OCc1ccccc1)NC(=O)OCc1ccccc1,,ClCCl,,CCOCC,FB(F)F,val
US20060160864A1,CCCCOCCOc1ccc(-c2ccc(N3CCCCC3)c(/C=C/C(=O)OCC)c2)cc1>>CCCCOCCOc1ccc(-c2ccc(N3CCCCC3)c(/C=C/C(=O)O)c2)cc1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20130289238A1,COc1cc(OCc2ccccc2)c2cc(-c3cn4nc(C)ccc4n3)oc2c1>>COc1cc(O)c2cc(-c3cn4nc(C)ccc4n3)oc2c1,[Pd],CO,ClCCl,[H][H],,val
US20130231328A1,CC(C)(C)[Si](C)(C)OC(C#N)C[C@H]1CCc2sc3ncnc(OC4CCC(N5CCOCC5)CC4)c3c21.OO>>CC(C)(C)[Si](C)(C)OC(C[C@H]1CCc2sc3ncnc(OC4CCC(N5CCOCC5)CC4)c3c21)C(N)=O,,CO,,O,[Li]O,val
US20070225324A1,COC(=O)C(c1ccc(Cl)cc1)n1ccc2c(N)cccc2c1=O.N>>NC(=O)C(c1ccc(Cl)cc1)n1ccc2c(N)cccc2c1=O,,CO,,,,val
US20100216813A1,Cc1cc(CBr)no1.N#Cc1ccc(N(Cc2ccccc2C(F)(F)F)[C@H]2CCNC2)cc1Cl>>Cc1cc(CN2CC[C@H](N(Cc3ccccc3C(F)(F)F)c3ccc(C#N)c(Cl)c3)C2)no1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150376181A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ncnc(NC(=O)C2CC2)c1F>>Nc1ncnc(NC(=O)C2CC2)c1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US04399134,CC1Cc2c(Cl)c(F)cc3c(=O)c(C(=O)O)cn1c23.O=C1CCCN1>>CC1Cc2c(N3CCCC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,,CN(C)P(=O)(N(C)C)N(C)C,,,,val
US04992422,CCCCCCCCCCCCN1CCCCCC1=O>>CCCCCCCCCCCCN1CCCCCC1,,CCOCC,,[H-].[Na+],,val
US05932599,CC(=O)N(C)c1cc(N(C)C(C)=O)cc([N+](=O)[O-])c1>>CC(=O)N(C)c1cc(N)cc(N(C)C(C)=O)c1,[Pd],CCO,,[H][H],,val
US20080269193A1,Cc1nn(-c2cc(F)c(C(N)=O)c(N[C@H]3CCC[C@@H]3OC(=O)CNC(=O)OC(C)(C)C)c2)c2c1C(=O)CC(C)(C)C2>>Cc1nn(-c2cc(F)c(C(N)=O)c(N[C@H]3CCC[C@@H]3OC(=O)CN)c2)c2c1C(=O)CC(C)(C)C2,,C1COCCO1,,CS(=O)(=O)O,,val
US20090131458A1,COCC(C)Oc1nc(N)c2nc(OC)[nH]c2n1.CS(=O)(=O)OCC1CCCOC1>>COCC(C)Oc1nc(N)c2nc(OC)n(CC3CCCOC3)c2n1,,CCOC(C)=O,CN(C)C=O,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US05672707,CC1(C)CC(=O)CC(=O)C1.Cc1ccc(C)c(C#N)c1N.Cl>>Cc1ccc(C)c(NC2=CC(=O)CC(C)(C)C2)c1C#N.Cl,,C1CCOC1,,,,val
US20040006071A1,COCOc1ccc(C=O)cc1C.NO>>COCOc1ccc(C=NO)cc1C,,C1COCCO1,CCOC(C)=O,CCN(CC)CC,Cl,val
US20030220304A1,C1COCCN1.COc1cc(C(=O)Cl)cc(OC)c1OC>>COc1cc(C(=O)N2CCOCC2)cc(OC)c1OC,,Cc1ccccc1,,,,val
US20120041009A1,O=C(Cl)N1CCCC1.O=c1nc(-c2cc(C(F)F)ncn2)[nH]o1>>O=C(N1CCCC1)n1c(-c2cc(C(F)F)ncn2)noc1=O,,c1ccncc1,,C1CCC2=NCCCN2CC1,,val
US05356885,C#CCN1CC[C@H](O)C1=O.CC(=O)OC(C)=O>>C#CCN1CC[C@H](OC(C)=O)C1=O,CN(C)c1ccncc1,CO,,ClCCl,c1ccncc1,val
US20100069349A1,C1=COCCC1.O=C1CC[C@@H](CO)O1>>O=C1CC[C@@H](COC2CCCCO2)O1,,ClCCl,,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20080255115A1,Brc1ccccn1.CC1(C)OB(c2ccnc3ccc(C=O)cc23)OC1(C)C>>O=Cc1ccc2nccc(-c3ccccn3)c2c1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20100216821A1,Nc1ccc(C(F)(F)F)cc1N.O=C(O)C1CCC2(CC1)CC(=O)N(c1ccccc1)C2>>Nc1ccc(C(F)(F)F)cc1NC(=O)C1CCC2(CC1)CC(=O)N(c1ccccc1)C2,,c1ccncc1,,CCN=C=NCCCN(C)C,,val
US20150080412A1,CCOC(=O)Cc1cccc(B2OC(C)(C)C(C)(C)O2)c1.CCn1c(CCCc2ccc(Br)cc2)nn(Cc2ccc(C(C)(C)C)cc2)c1=O>>CCOC(=O)Cc1cccc(-c2ccc(CCCc3nn(Cc4ccc(C(C)(C)C)cc4)c(=O)n3CC)cc2)c1,,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US05962469,CC(C)(O)Cc1cccc(O)c1.O=C1CCC(=O)N1Br>>CC(C)(O)Cc1cc(O)ccc1Br,,CN(C)C=O,,O,,val
US20070105900A1,CC(C)(C)OC(=O)NS(C)(=O)=O.CC(C)Cc1[nH]c(-c2nn(C3CCCCO3)cc2NC(=O)c2c(F)cccc2F)nc1CCO>>CC(C)Cc1[nH]c(-c2nn(C3CCCCO3)cc2NC(=O)c2c(F)cccc2F)nc1CCN(C(=O)OC(C)(C)C)S(C)(=O)=O,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05807889,CNCC1CCc2ccc(NC(C)=O)cc21.CS(=O)(=O)OCCCCC1CCCCC1>>CC(=O)Nc1ccc2c(c1)C(CN(C)CCCCC1CCCCC1)CC2,,CC(=O)CC(C)C,,[I-].[K+],,val
US20160016908A1,CC(=O)N1c2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2[C@H](N)[C@@H](C)[C@@H]1C.Fc1ncccn1>>CC(=O)N1c2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2[C@H](Nc2ncccn2)[C@@H](C)[C@@H]1C,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20100152445A1,O=[N+]([O-])c1ccc(N2CCC(c3cccc(C(F)(F)F)c3)CC2)nc1>>Nc1ccc(N2CCC(c3cccc(C(F)(F)F)c3)CC2)nc1,[Pd],CCO,,,,val
US20060155128A1,CO.O=[N+]([O-])c1ccnc(Cl)c1O>>COc1c([N+](=O)[O-])ccnc1Cl,,CC#N,CO,C[Si](C)(C)C=[N+]=[N-],,val
US20110312979A1,CC(=O)c1cc2c(Cl)cccc2n1-c1cccc(F)c1.[NH4+]>>CC(N)c1cc2c(Cl)cccc2n1-c1cccc(F)c1,,CC#N,CO,[BH3-]C#N.[Na+],,val
US20020151587A1,CCN(CC)S(F)(F)F.O=C1CC2C(CC(OC(=O)c3ccccc3)C2CCC(O)COc2cccc(Cl)c2)O1>>O=C1CC2C(CC(OC(=O)c3ccccc3)C2CCC(F)COc2cccc(Cl)c2)O1,,ClCCl,,O=C([O-])O.[Na+],,val
US20100168063A1,COC(=O)/C(OC(C)=O)=C(\OC(C)=O)C(=O)OC.Cc1cc(N)no1>>COC(=O)c1nc2cc(C)on2c(=O)c1O,Cc1ccc(S(=O)(=O)O)cc1,CCO,,CC(C)OC(C)C,,val
US20040110945A1,Cc1nccc2ccccc12.O=[Se]=O>>O=Cc1nccc2ccccc12,,C1COCCO1,,,,val
US05047411,CCN(C=O)c1nc2ccc(C)cc2o1.O=C1CCC(=O)N1Br>>CCN(C=O)c1nc2ccc(CBr)cc2o1,,c1ccccc1,,CCOC(C)=O,,val
US20060135578A1,CCN=C=NCCCN(C)C.COc1cc(COc2nn(-c3ccccc3)cc2/C=C/C(=O)O)ccc1OCc1nc(-c2ccco2)oc1C>>COc1cc(COc2nn(-c3ccccc3)cc2/C=C/C(N)=O)ccc1OCc1nc(-c2ccco2)oc1C,,O,,CN(C)C=O,Cl,val
US20130005744A1,Cl[Mg]Cc1ccccc1.Cn1c(C=O)c(Br)cc(OCc2ccccc2)c1=O>>Cn1c(C(O)Cc2ccccc2)c(Br)cc(OCc2ccccc2)c1=O,,C1CCOC1,,,,val
US05089504,CCCC(=O)c1cnc2c(OC)cccc2c1Cl>>CCCC(=O)c1cnc2c(O)cccc2c1Cl,,ClCCl,,BrB(Br)Br,,val
US20030119820A1,NNc1ccc(C(=O)O)cc1.O=C(Cc1ccccc1)c1ccccc1>>O=C(O)c1ccc2[nH]c(-c3ccccc3)c(-c3ccccc3)c2c1,,O,,CC(=O)O,Cl,val
US20090143444A1,CCOC(C)=O.CCOC(C)=O.CN(Cc1cc(-c2cccnc2F)n(S(=O)(=O)c2cccnc2)c1)C(=O)OC(C)(C)C>>CNCc1cc(-c2cccnc2F)n(S(=O)(=O)c2cccnc2)c1.O=C(O)/C=C/C(=O)O,,CO,,Cl,,val
US20100016387A1,Cc1ccc(NC(=O)c2ccc(N)c(NCCO)c2)cc1C.O=Cc1ccc(Cl)cc1>>Cc1ccc(NC(=O)c2ccc3nc(-c4ccc(Cl)cc4)n(CCO)c3c2)cc1C,,CO,,,,val
US20070155776A1,Cc1sc2cc[nH]c(=O)c2c1Br.O=[N+]([O-])O>>Cc1sc2c([N+](=O)[O-])c[nH]c(=O)c2c1Br,,O=S(=O)(O)O,,,,val
US04772622,CCOC(OCC)OCC.N=C(N)Nc1nc(-c2cccc(N)c2)cs1>>CNc1cccc(-c2csc(NC(=N)N)n2)c1,O=C(O)C(F)(F)F,,,,,val
US20090075979A1,CC(C)CNc1ccc(OC(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C.COC(=O)Cl>>COC(=O)N(CC(C)C)c1ccc(OC(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20140315889A1,CCOC(=O)CCCCCn1c(C)c(C)c2c1CC(C)(C)CC2=O>>Cc1c2c(n(CCCCCC(=O)O)c1C)CC(C)(C)CC2=O,,CO,O,,,val
US20130338137A1,CC1(C)C(=O)Nc2nc(-c3nn(Cc4ccccc4F)c4ncccc34)nc(I)c21.FC(F)(F)C1CNCCO1>>CC1(C)C(=O)Nc2nc(-c3nn(Cc4ccccc4F)c4ncccc34)nc(N3CCOC(C(F)(F)F)C3)c21,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20070003539A1,Cl.N#Cc1ccccc1S(=O)(=O)C1CC1>>Cl.NCc1ccccc1S(=O)(=O)C1CC1,,C1CCOC1,,CSC,,val
US04925838,CI.CS(=O)(=O)O[C@@H]1C[C@@H](CN2CCNC2=O)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1>>CN1CCN(C[C@@H]2C[C@@H](OS(C)(=O)=O)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)C1=O,,CN(C)C=O,,[Na+].[OH-],,val
US20110021501A1,CCCI.O=C1CC[C@H](N(Cc2ccccc2)Cc2ccccc2)CN1>>CCCN1C[C@@H](N(Cc2ccccc2)Cc2ccccc2)CCC1=O,,CN(C)C=O,,[H-].[Na+],,val
US20160235752A1,O=C(Cl)c1ccccc1.O=C1CC(=O)NC(=O)N1>>O=C1NC(=O)C(C(=O)c2ccccc2)C(=O)N1,,c1ccncc1,,,,val
US20130203775A1,CC(C)Oc1cc2c(-c3ncc[nH]3)c(-c3ccc(F)cc3)oc2cc1[N+](=O)[O-]>>O=[N+]([O-])c1cc2oc(-c3ccc(F)cc3)c(-c3ncc[nH]3)c2cc1O,,ClCCl,,ClB(Cl)Cl,,val
US05744488,CN(C)Cc1c[nH]c2ccc([N+](=O)[O-])cc12.c1c[nH]cn1>>O=[N+]([O-])c1ccc2[nH]cc(Cn3ccnc3)c2c1,,Cc1ccccc1C,,,,val
US20120190543A1,CC(C)(C)OC(=O)Nc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1.CI>>CN(C(=O)OC(C)(C)C)c1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20150232481A1,BrCc1ccccc1.OCCc1c(O)ccc(F)c1F>>OCCc1c(OCc2ccccc2)ccc(F)c1F,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US05908858,CS(=O)(=O)c1ccc(-c2cccn2-c2ccc(F)cc2)cc1.F[Xe]F>>CS(=O)(=O)c1ccc(-c2ccc(F)n2-c2ccc(F)cc2)cc1,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US06004977,COCCl.COc1cc(CCCNNc2ccncc2)ccc1O[Si](C)(C)C(C)(C)C>>COc1cc2c(cc1O[Si](C)(C)C(C)(C)C)CN(Nc1ccncc1)CCC2,,CC(=O)O,,,,val
US20120225886A1,CN(CCc1ccccn1)C(=O)c1ccc(C[C@@H]2CC[C@H]([C@H](O[Si](C)(C)C(C)(C)C)c3ccccc3)N2C(=O)OC(C)(C)C)cc1>>CN(CCc1ccccn1)C(=O)c1ccc(C[C@@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1,,CC#N,,O,O=C(O)C(F)(F)F,val
US20130317029A1,CSc1nc(Cl)c(C#N)c(Cl)n1.Nc1cccc(-c2ncccn2)c1>>CSc1nc(Cl)c(C#N)c(Nc2cccc(-c3ncccn3)c2)n1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20110251190A1,Cc1cnc(F)c(B(O)O)c1.NC1=N[C@@]2(CO1)c1cc(OS(=O)(=O)C(F)(F)F)ccc1Oc1c(F)cc(N3CCOCC3)cc12>>Cc1cnc(F)c(-c2ccc3c(c2)[C@@]2(COC(N)=N2)c2cc(N4CCOCC4)cc(F)c2O3)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20100216810A1,CC(=O)Nc1nc2ccc(Oc3cccc(N)c3)c(C#N)c2s1.O=C=Nc1ccc(OC(F)(F)F)cc1>>CC(=O)Nc1nc2ccc(Oc3cccc(NC(=O)Nc4ccc(OC(F)(F)F)cc4)c3)c(C#N)c2s1,,CCOC(C)=O,CN(C)C=O,,,val
US20020137755A1,N#Cc1cnc(Cl)s1.Nc1cc(Cl)ncn1>>N#Cc1cnc(Nc2cc(Cl)ncn2)s1,,C1CCOC1,,[H-].[Na+],,val
US05397801,COC(=O)C(C)N(c1ccc(Cl)cc1C(=O)c1ccccc1Cl)S(=O)(=O)c1ccc(C)cc1>>COC(=O)C1(C)N(S(=O)(=O)c2ccc(C)cc2)c2ccc(Cl)cc2C1(O)c1ccccc1Cl,,CN(C)C=O,,C[O-].[Na+],,val
US05047411,Cc1ccn2c(C)c(CCc3ccc4nc(N)oc4c3)nc2c1.Cl.Cl>>Cc1c(CCc2ccc3nc(N)oc3c2)nc2n1CCC(C)C2.Cl.Cl,[Pd],CO,,,,val
US05674886,N#Cc1ccc(C=Nn2cnnc2)cc1>>N#Cc1ccc(CNn2cnnc2)cc1,,CO,,[BH4-].[Na+],,val
US20060194801A1,COC(=O)c1ccc(/C=C(\C)C(F)(F)F)cc1>>C/C(=C\c1ccc(C(=O)O)cc1)C(F)(F)F,,C1CCOC1,CO,[Na+].[OH-],,val
US20130131016A1,C=C(c1cc(Cl)c(F)c(Cl)c1)C(F)(F)F.CC1(C)OB(O)c2ccc(C(Cl)=NO)cc21>>CC1(C)OB(O)c2ccc(C3=NOC(c4cc(Cl)c(F)c(Cl)c4)(C(F)(F)F)C3)cc21,,CN(C)C=O,,,,val
US20020134266A1,CCC(C)=O.CO.Oc1cccc(O)c1O>>C=O.Cc1ccccc1O,,CO,,CC(C)=O,,val
US05167863,CCCCI.C[C@H](O)[C@@H](C)OCc1ccccc1>>CCCCO[C@@H](C)[C@@H](C)OCc1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US20130261105A1,O=C(O)c1cc2ncc(Br)cn2n1.c1cnc2c(c1)CCNCC2>>O=C(c1cc2ncc(Br)cn2n1)N1CCc2cccnc2CC1,,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US20130261116A1,CN(C)CCCOc1ccc(B2OC(C)(C)C(C)(C)O2)cc1F.CNC(=O)c1ccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1F>>CN(C)CCCOc1ccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1F,,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US05608056,CS(=O)(=O)Cl.O=C(OCc1ccccc1)N1C[C@H](O)C[C@H]1/C=C\c1cccnc1>>CS(=O)(=O)O[C@@H]1C[C@@H](/C=C\c2cccnc2)N(C(=O)OCc2ccccc2)C1,,CCN(CC)CC,CCOC(C)=O,O,,val
US05849759,Cc1nc2cc(OC3CCN(C(=O)OC(C)(C)C)CC3)c(O[Si](C)(C)C(C)(C)C)cc2n1Cc1ccc(C#N)c2ccccc12>>Cc1nc2cc(OC3CCN(C(=O)OC(C)(C)C)CC3)c(O)cc2n1Cc1ccc(C#N)c2ccccc12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20140275153A1,O=[N+]([O-])c1ccc(Br)cc1NCc1cncc(F)c1>>Nc1ccc(Br)cc1NCc1cncc(F)c1,[Ni],CO,O,NN,,val
US20150225389A1,COc1ccc(CN(C(=O)OC(C)(C)C)c2cc(C[C@H]3C(=O)N(C(=O)N[C@H](C)C4CCCCC4)[C@@H]3C(=O)OCc3ccccc3)ccn2)cc1>>COc1ccc(CN(C(=O)OC(C)(C)C)c2cc(C[C@H]3C(=O)N(C(=O)N[C@H](C)C4CCCCC4)[C@@H]3C(=O)O)ccn2)cc1,[Pd],CCOC(C)=O,CO,,,val
US04009208,CCOC(=O)C(=O)NCCCCCCC#N.N#CCCCCCCN>>NCCCCCCCNCCO,,c1ccncc1,,c1ccccc1,,val
US06403610B1,COC(=O)[C@H]1CN(CCSc2ccccc2)CC[C@H]1CCCc1ccnc2ccc(OC)cc12>>COc1ccc2nccc(CCC[C@@H]3CCN(CCSc4ccccc4)C[C@@H]3C(=O)O)c2c1,,CO,,CC(=O)O,[Na+].[OH-],val
US04386099,CCOC=Nc1ccccc1.Nc1ccc(-c2c[nH]cn2)cc1>>C(=Nc1ccc(-c2c[nH]cn2)cc1)Nc1ccccc1,,CC(C)=O,,,,val
US05589492,COC(=O)C(Cl)Cc1ccc(OCCN(C)c2nc3ccccc3o2)cc1.N>>CN(CCOc1ccc(CC(Cl)C(N)=O)cc1)c1nc2ccccc2o1,,CO,,C1CCOC1,,val
US20080312242A1,COc1ccccc1CCl.OCCCOc1ccc(Br)cn1>>COc1ccccc1COCCCOc1ccc(Br)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20110312911A1,CCC[C@H](c1ccc(C(=O)NCCC(=O)O)cc1)C(Oc1ccc(Br)c(C#N)c1)c1ccc(Cl)cc1.Cc1ccc(B(O)O)cc1>>CCC[C@H](c1ccc(C(=O)NCCC(=O)O)cc1)[C@@H](Oc1ccc(-c2ccc(C)cc2)c(C#N)c1)c1ccc(Cl)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US04487773,CCC(O)Cl.CCc1n[nH]c(=O)n1CCOc1ccccc1>>CCc1nn(CCCO)c(=O)n1CCOc1ccccc1,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20100317693A1,CC(C)C[C@@H](NC(=O)C(C)(C)N)C(=O)NC1Cc2cccc(N3CCCC3=O)c2N(Cc2ccsc2)C1=O.O=C1O[C@H]([C@@H](O)CO)C(O)=C1O>>CC(C)C[C@@H](NC(=O)C(C)(C)N)C(=O)NC1Cc2cccc(N3C(=O)CCC3O)c2N(Cc2ccsc2)C1=O,,CC(=O)O,O,O=O,,val
US20050032838A1,COC(=O)Cl.CSc1cccc(Oc2ncc(F)cc2C(=O)N[C@H]2CC[C@@H](N)CC2)c1>>COC(=O)N[C@@H]1CC[C@H](NC(=O)c2cc(F)cnc2Oc2cccc(SC)c2)CC1,,ClCCl,,CCN(CC)CC,Cl,val
US05175342,CCCCOC(=O)Cl.COc1c(O)cc2c(c1OC)-c1ccc(SC)c(=O)cc1[C@@H](NC(C)=O)CC2>>CCCCOC(=O)Oc1cc2c(c(OC)c1OC)-c1ccc(SC)c(=O)cc1C(NC(C)=O)CC2,,c1ccncc1,,Cl,,val
US20160176858A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@@H]1CC[C@@H](c2nc(C(N)=O)c(Br)o2)CN1C(=O)c1ccccc1-n1nccn1>>C[C@@H]1CC[C@@H](c2nc(C(=O)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(Br)o2)CN1C(=O)c1ccccc1-n1nccn1,CN(C)c1ccncc1,CC#N,,[Cl-].[NH4+],,val
US20030171396A1,COC(=O)c1ccc2nc(C)n(Cc3ccc(N(C)C(=O)OC(C)(C)C)cc3Cl)c2n1.Cl.ClCCl>>CNc1ccc(Cn2c(C)nc3ccc(C(=O)OC)nc32)c(Cl)c1.Cl.Cl,,ClCCl,,,,val
US20100160327A1,Nc1cc(-c2ccccc2)ccc1O.O=C(O)c1ccc(C(C(=O)Nc2ccccc2)C(=O)Nc2ccccc2)cc1>>O=C(Nc1cc(-c2ccccc2)ccc1O)c1ccc(C(C(=O)Nc2ccccc2)C(=O)Nc2ccccc2)cc1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20080280869A1,CC(C)c1ccc(C(=O)O)cc1.CCOC(=O)CNN>>CCOC(=O)CNNC(=O)c1ccc(C(C)C)cc1,,C1CCOC1,ClCCl,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20110190334A1,Cc1c(Nc2ccc(I)cc2F)c(NS(=O)(=O)C2(CCCOCc3ccccc3)CC2)c2n(c1=O)CCO2>>Cc1c(Nc2ccc(I)cc2F)c(NS(=O)(=O)C2(CCCO)CC2)c2n(c1=O)CCO2,,ClCCl,,ClB(Cl)Cl,,val
US20140155635A1,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.COc1cc2c(c(-c3cccc(C=O)c3)c1)C(=O)OC(C)(C)O2>>COC(=O)/C=C/c1cccc(-c2cc(OC)cc3c2C(=O)OC(C)(C)O3)c1,,ClCCl,O,,,val
US20150307532A1,CN(C)C(=N)c1scc([Si](C)(C)C)c1C#N.O=C1CCC(=O)N1Br>>CN(C)C(=N)c1sc(Br)c([Si](C)(C)C)c1C#N,,CCOC(C)=O,CN(C)C=O,,,val
US05294612,CCc1[nH]n(C2CCCC2)c2nc(-c3cc(C)nc(Cl)c3)nc(=O)c1-2.c1c[nH]cn1>>CCc1[nH]n(C2CCCC2)c2nc(-c3cc(C)nc(-n4ccnc4)c3)nc(=O)c1-2,,CN1CCCC1=O,,,,val
US07495007B2,C[Si](C)(C)C#Cc1ccc(OCC(O)CO)c(C2NC(=O)CC(c3cccc(Cl)c3)C23C(=O)Nc2cc(Cl)ccc23)c1>>C#Cc1ccc(OCC(O)CO)c(C2NC(=O)CC(c3cccc(Cl)c3)C23C(=O)Nc2cc(Cl)ccc23)c1,,CO,,[Na+].[OH-],,val
US20090227803A1,COc1ccccc1CN.C[Si](C)(C)CCl>>COc1ccccc1CNC[Si](C)(C)C,,CC#N,,,,val
US20140094474A1,C[C@H](N)Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1.O=C(O)c1noc(-c2ccon2)n1>>C[C@@H](Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1)NC(=O)c1noc(-c2ccon2)n1,,CCOC(C)=O,O,CN(C)C=O,,val
US05646289,CC(C)(C)NC(=O)N1CCC(O)C1.CCCCOc1nsnc1S(C)(=O)=O>>CCCCOc1nsnc1OC1CCNC1,,C1CCOC1,,[H-].[Na+],,val
US06245801B1,CC(C)CC=C(Br)Br.CCOC(=O)Cl>>CCOC(=O)C#CCC(C)C,,C1CCOC1,,[Li]CCCC,,val
US20080021032A1,CC(C)(C)OC(=O)Nc1cccc(Cn2ccc(NC(=O)[C@H](CC3CCCC3)c3ccc(S(C)(=O)=O)c(Cl)c3)n2)c1.CO>>COC(=O)Cc1ccc(SC)c(C)c1,O=S(=O)(O)O,,,ClC(Cl)Cl,,val
US20020165264A1,CC(C)(C(=O)O)c1ccccc1.CN(C)C=O>>CC(C)(C(N)=O)c1ccccc1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20110081409A1,CCOC(=O)c1ccc([N+](=O)[O-])c(NCc2ccccc2)c1>>CCOC(=O)c1ccc(N)c(NCc2ccccc2)c1,[Zn],CC(=O)O,CCO,,,val
US20140350030A1,COP(=O)(OC)C(=[N+]=[N-])C(C)=O.O=CC12CC3CC(C1)CC(NC(=O)c1cccc(Cl)c1)(C3)C2>>C#CC12CC3CC(C1)CC(NC(=O)c1cccc(Cl)c1)(C3)C2,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20160024079A1,C=C[Mg]Br.Cc1cc(Br)c(C#N)cc1[N+](=O)[O-]>>Cc1cc(Br)c(C#N)c2cc[nH]c12,,C1CCOC1,,,,val
US20130231328A1,CNC1CCC(Oc2ncnc3sc4c(c23)[C@@H](CCO)CC4)CC1.O=C(CCl)N1CCCC1>>CN(CC(=O)N1CCCC1)C1CCC(Oc2ncnc3sc4c(c23)[C@@H](CCO)CC4)CC1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US04602032,CCCBr.CCN1C(=O)c2cc(C)cc3c2c1cc1ccc(OC)c(OC)c13>>CCCC1(O)c2cc(C)cc3c2c(cc2ccc(OC)c(OC)c23)N1CC,,C1CCOC1,,[Mg],,val
US05428002,C=C[Mg]Cl.COc1cc(OC)nc(Oc2cccc3c2C(=O)OC3O)n1>>C=CC1OC(=O)c2ccccc21,,C1CCOC1,,Cl,,val
US20110306612A1,COC(=O)c1ccccc1C(F)F>>O=C(O)c1ccccc1C(F)F,,CO,,Cl,[Na+].[OH-],val
US20060229318A1,CC(C)(C)OC(=O)N1CCCNCC1.c1ccc2c(c1)CCC1OC21>>CC(C)(C)OC(=O)N1CCCN([C@@H]2c3ccccc3CC[C@H]2O)CC1,,CC#N,,,,val
US20090311217A1,COc1cc(OC)c2c(c1)OCC2=O.Cn1c(-c2ccccc2)c(C=O)c2ccccc21>>COc1cc(OC)c2c(c1)O/C(=C\c1c(-c3ccccc3)n(C)c3ccccc13)C2=O,Cl,CCO,,,,val
US20060160864A1,CC1CCNCC1.O=Cc1cc(Br)ccc1F>>CC1CCN(c2ccc(Br)cc2C=O)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080045493A1,Cn1cc(-c2ccccc2)cn1.O=S(=O)(O)Cl>>Cn1cc(-c2ccc(S(=O)(=O)Cl)cc2)cn1,,ClCCl,,,,val
US20040180939A1,CCOCC.COC(=O)c1cccc(Br)c1.C[Mg]Br>>CC(C)(O)c1cccc(Br)c1,,C1CCOC1,,,,val
US20100127215A1,CC(=O)Cl.c1ccc2c(c1)c1ccccc1c1ccccc21>>CC(=O)c1cccc2c3ccccc3c3ccccc3c12,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US07491737B2,C=C1CCC(C(=O)OC)(C(C)C)C1>>C=C1CCC(C(=O)O)(C(C)C)C1,,C1COCCO1,O,CO,[Li+].[OH-],val
US03987057,Nc1ccc(Br)cc1F.O=C1OC(=O)C2CCCCC12>>O=C1C2CCCCC2C(=O)N1c1ccc(Br)cc1F,,CC(=O)O,,,,val
US20070299087A1,NC(c1cccc(Br)c1)c1ccncc1F.S=C(n1ccnc1)n1ccnc1>>Fc1cnccc1C(N=C=S)c1cccc(Br)c1,,ClCCl,,,,val
US05550257,O=C(Cl)C(=O)Cl.O=C(O)CCC1CCCC1>>O=C(Cl)CCC1CCCC1,,ClCCl,,,,val
US06294503B1,CN1C(=O)COc2cc(F)c(N3C(=O)C4=C(CCCC4)C3=O)c(N)c21.O=C(Cl)c1ccc2ccccc2c1>>CN1C(=O)COc2cc(F)c(N3C(=O)C4=C(CCCC4)C3=O)c(NC(=O)c3ccc4ccccc4c3)c21,,C1COCCO1,,,,val
US20160102059A1,COc1cc(NC(=O)OC(C)(C)C)cc(OC)c1C(=O)NCCOCCOCCO>>COc1cc(N)cc(OC)c1C(=O)NCCOCCOCCO,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080275054A1,CCN(CC)CCO.CCOC(=O)/N=N/C(=O)OCC.Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(Cl)nc2[nH]ncc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCN(CC)CCn1ncc2c(Nc3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)nc(-c3cccnc3)nc21,,C1CCOC1,,,,val
US20070185101A1,CC(C)(C)OC(=O)N1CCCC(CO)C1.Sc1ccccn1>>CC(C)(C)OC(=O)N1CCCC(CSc2ccccn2)C1,,c1ccccc1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20150065482A1,CCOC(=O)c1nn(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)c2c1CN(CC(C)(C)O)CC2.N>>CN1CC[C@@](O)(C#Cc2cccc(-n3nc(C(N)=O)c4c3CCN(CC(C)(C)O)C4)c2)C1=O,,CO,,,,val
US20100298330A1,CC(C)(C)OC(=O)NCC=O.CCOC(=O)C(F)P(=O)(OCC)OCC>>CCOC(=O)/C(F)=C\CNC(=O)OC(C)(C)C,,C1CCOC1,,O,[Li]CCCC,val
US20090176732A1,CCOC1(C)OCC(C#N)(C(=O)OC)CO1>>COC(=O)C(C#N)(CO)COC(C)=O,,CC(=O)O,O,,,val
US03971793,CCOc1c(OC)c2c(c(OC)c1C(=O)C=Cc1ccc(OC)cc1)CC(N1CCCCC1)O2>>CCOc1c(OC)c2c(c(OC)c1C(O)CCc1ccc(OC)cc1)CC(N1CCCCC1)O2,,c1ccncc1,,[BH4-].[Na+],,val
US20130085164A1,CCC(O)c1cnc(-c2ccn(C)n2)s1.O=C(n1ccnc1)n1ccnc1>>CCC(c1cnc(-c2ccn(C)n2)s1)n1ccnc1,,CC#N,,CO,ClCCl,val
US06780855B2,CNCCCCCCC(F)(F)C(F)(F)F.C[C@]12C[C@H](F)[C@@H]3c4ccc(O)cc4C[C@@H](CCCCCCI)[C@H]3[C@@H]1CCC2O>>CN(CCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12)CCCCCCC(F)(F)C(F)(F)F,,CN1CCCC1=O,,[Cl-].[Na+],,val
US20060148858A1,COCOCCCc1c[nH]nc1C(C)C.FC(F)(F)c1ccc(Cl)nn1>>CC(C)c1nn(-c2ccc(C(F)(F)F)nn2)cc1CCCO,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US20150232460A1,C=CCN(CC=C)C1CC(OCc2ccc(OC)cc2)CC1N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=CCN(CC=C)C1CC(OCc2ccc(OC)cc2)CC1NC(=O)OC(C)(C)C,,C1CCOC1,,O=C([O-])[O-].[Na+].[Na+],,val
US20090012063A1,CCCCCCc1cccc(-c2nc(C#CCOC)c(C(=O)N3CCC(N4CCCC4)CC3)n2C)c1>>CCCCCCc1cccc(-c2nc(CCCOC)c(C(=O)N3CCC(N4CCCC4)CC3)n2C)c1,O=[Pt],,,,,val
US20040225111A1,CCOC(=O)CCCOc1ccc(C[C@H](NC(=S)Nc2ccc(OC)cc2N)C(=O)OC(C)(C)C)cc1>>CCOC(=O)CCCOc1ccc(C[C@H](Nc2nc3cc(OC)ccc3[nH]2)C(=O)OC(C)(C)C)cc1,Cl[Hg]Cl,CN(C)C=O,,,,val
US20050020605A1,CCON=C(c1ccc(Br)cc1)C1CCN(C2(C)CCNCC2)CC1.Cc1nc2ccccc2c(C(=O)O)c1O>>CCON=C(c1ccc(Br)cc1)C1CCN(C2(C)CCN(C(=O)c3c(O)c(C)nc4ccccc34)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120014913A1,COc1c(-c2ccc3cc(O)ccc3c2)cc(-n2ccc(=O)[nH]c2=O)cc1C(C)(C)C.O=S(=O)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>COc1c(-c2ccc3cc(OS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)ccc3c2)cc(-n2ccc(=O)[nH]c2=O)cc1C(C)(C)C,,CN(C)C=O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20130005707A1,Brc1ccc2cn[nH]c2c1.CC(C)I>>CC(C)n1ncc2ccc(Br)cc21,,CN(C)C=O,,O,[H-].[Na+],val
US05364866,ClCCCBr.Oc1cccc2cc[nH]c12>>ClCCCOc1cccc2cc[nH]c12,,CN(C)C=O,,O,[H-].[Na+],val
US06441176B1,N=C(N)N.O=C(Cl)c1cnn(-c2cccc3ncccc23)c1C1CC1>>N=C(N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C1CC1,,C1CCOC1,,Cl,[Na+].[OH-],val
US20070060565A1,O=C(O)c1ccc2c(C3=CCCCC3)c[nH]c2c1>>O=C(O)c1ccc2c(C3CCCCC3)c[nH]c2c1,,C1CCOC1,,CO,,val
US20040014962A1,CS(=O)(=O)Cl.O=C(N[C@@H]1CCN(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1)c1coc(N2CC(O)C2)n1>>CS(=O)(=O)OC1CN(c2nc(C(=O)N[C@@H]3CCN(C(=O)OCc4ccc([N+](=O)[O-])cc4)C3)co2)C1,,ClCCl,,CCN(CC)CC,,val
US20100249192A1,O=[N+]([O-])c1ccc(F)cc1.Oc1cc(F)ccc1Cl>>O=[N+]([O-])c1ccc(Oc2cc(F)ccc2Cl)cc1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20020188009A1,CCOC(=O)C(CC)CCCCCn1c(C)nc(-c2ccccc2)c1-c1ccccc1>>CCC(CCCCCn1c(C)nc(-c2ccccc2)c1-c1ccccc1)C(=O)O,,CO,,[Na+].[OH-],,val
US20020013310A1,COc1ccc2ccc(S(=O)(=O)Cl)cc2c1.N[C@H]1CCN(Cc2ccc3ccc(Cl)nc3c2)C1=O>>COc1ccc2ccc(S(=O)(=O)N[C@H]3CCN(Cc4ccc5ccc(Cl)nc5c4)C3=O)cc2c1,,ClCCl,,Cl,,val
US20150218092A1,COc1cc([N+](=O)[O-])ccc1C=O>>COc1cc([N+](=O)[O-])ccc1CO,,CO,,[BH4-].[Na+],,val
US20150183802A1,CC(C)CO.Fc1ncc(Br)cc1Cl>>CC(C)COc1ncc(Br)cc1Cl,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20050009831A1,COc1ccc(N)cc1.N#CN=C(Oc1ccccc1)Oc1ccccc1>>COc1ccc(NC(=NC#N)Oc2ccccc2)cc1,,CC(C)O,,,,val
US20150252069A1,COc1cc(C[C@@]2(CCO[Si](C)(C)C(C)(C)C)OC(C)(C)O[C@H]2C)c(OC)c2c(OC)c3ccccc3c(OC)c12>>COc1cc(C[C@@]2(CCO)OC(C)(C)O[C@H]2C)c(OC)c2c(OC)c3ccccc3c(OC)c12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20100256134A1,CC(C)(C)OC(=O)N1CC2(CCN(C(=O)c3cnc4c(C(=O)NS(C)(=O)=O)cnn4c3NCc3ccccc3)CC2)c2ccccc21>>CS(=O)(=O)NC(=O)c1cnn2c(NCc3ccccc3)c(C(=O)N3CCC4(CC3)CNc3ccccc34)cnc12,,C1COCCO1,Cl,,,val
US04727080,CCCBr.CCOC(=O)c1cnc2cc(-n3cccc3)c(F)cc2c1O>>CCCn1cc(C(=O)OCC)c(=O)c2cc(F)c(-n3cccc3)cc21,,O,,O=C([O-])[O-].[K+].[K+],,val
US05360568,C1=NCCc2ccccc21.COS(=O)(=O)c1ccc(C)cc1>>C[N+]1=Cc2ccccc2CC1.Cc1ccc(S(=O)(=O)[O-])cc1,,CO,,,,val
US20080167305A1,Cc1ccc2c(N3CC[C@@H](NC(=O)OCC(C)C)C3)nc(-c3ccccc3O)nc2c1.O=S(=O)(O)O>>Cc1ccc2c(N3CC[C@@H](NC(=O)OCC(C)C)C3)nc(-c3ccccc3O)nc2c1.O=S(=O)(O)O,,C1CCOC1,CC#N,,,val
US20040204386A1,CC(C)(C)OC(=O)NCC(=O)O.CCOc1ccc(Cl)cc1-c1cc(Nc2ccc(CO)cc2)nc(N)n1>>CCOc1ccc(Cl)cc1-c1cc(Nc2ccc(COC(=O)CNC(=O)OC(C)(C)C)cc2)nc(N)n1,,ClCCl,,,,val
US06051572,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1NCCN(C2CCNCC2)C1c1ccccc1>>CC(C)(C)OC(=O)N1CCC(N2CCNC(=O)C2c2ccccc2)CC1,,ClCCl,,,,val
US20070072813A1,CC(C)(C)[Si](C)(C)Cl.COc1ccc(Cc2c(O)n[nH]c2C(F)(F)F)c(F)c1>>COc1ccc(Cc2c(O[Si](C)(C)C(C)(C)C)n[nH]c2C(F)(F)F)c(F)c1,,CCOC(C)=O,CN(C)C=O,c1c[nH]cn1,,val
US04631277,BrC1C=CCCC1.O=Cc1ccccc1O>>O=Cc1ccccc1OC1C=CCCC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20030119670A1,Cc1ccc(-c2ccccc2)cc1CN.O=C(Cl)OC(Cl)(Cl)Cl>>Cc1ccc(-c2ccccc2)cc1CN=C=O,,Cc1ccccc1,,,,val
US20120208815A1,CC(C)(C)OC(=O)N1CCCC(C)(C(=O)O)C1>>CC1(C(=O)O)CCCNC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120053173A1,CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(OC4CCSCC4)cc3c2C)C(C)C)cc1>>Cc1c(C(Nc2ccc(C(=O)N(C)CCC(=O)O)cc2)C(C)C)oc2ccc(OC3CCSCC3)cc12,,C1CCOC1,CCO,[Na+].[OH-],,val
US20030055071A1,CCCC[Sn](CCCC)(CCCC)C1=CC(=O)OC1.O=C(NCc1ccc(F)cc1)c1nc(I)c2cccnc2c1O>>O=C1C=C(c2nc(C(=O)NCc3ccc(F)cc3)c(O)c3ncccc23)CO1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,,,,val
US20090054435A1,COCOc1ccc(OC)cc1C(=O)c1ccc(O)cc1.Cc1oc(-c2ccccc2)nc1CCl>>COCOc1ccc(OC)cc1C(=O)c1ccc(OCc2nc(-c3ccccc3)oc2C)cc1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05552397,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CS(=O)(=O)Cl.NCCO>>CC(C)(C)OC(=O)NCCOS(C)(=O)=O,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US06979690B2,CC(C)(C)OC(=O)N1CCC(CCC(=O)c2ccc(NC(=O)C(C)(C)C)nc2F)CC1.CO>>COc1nc(N)ccc1C(=O)CCC1CCN(C(=O)OC(C)(C)C)CC1,,CO,O,CC(C)(C)[O-].[K+],,val
US20060135445A1,COc1cc(-c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2)c([N+](=O)[O-])cc1OC>>COc1cc(N)c(-c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2)cc1OC,[Fe],CO,Cl,,,val
US20140371199A1,CC(=O)Cl.N#Cc1ccc(-c2cnn3ccc(-c4ccc(C(=O)N5CCC(N)CC5)cc4)nc23)cc1>>CC(=O)NC1CCN(C(=O)c2ccc(-c3ccn4ncc(-c5ccc(C#N)cc5)c4n3)cc2)CC1,,ClCCl,,,,val
US20020037888A1,Ic1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.N#Cc1ccc(C=O)cc1F>>N#Cc1ccc(C(O)c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1F,,ClCCl,,CC[Mg]Br,,val
US20080234521A1,CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)C(=O)[C@@H](O)CC2(C)C)C(C)(C)C[C@H](O)C1=O>>CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C2=C(C)C(=O)[C@@H](O)CC2(C)C)C(C)(C)C[C@H](O)C1=O,,c1ccncc1,,O,,val
US04739050,CN1C(=O)C(C#N)(c2ccc(O)cc2)Sc2ccccc21.ClCC1CO1>>CN1C(=O)C(C#N)(c2ccc(OCC3CO3)cc2)Sc2ccccc21,,CN(C)C=O,O,CCOC(C)=O,[H-].[Na+],val
US20150299125A1,CC(Cl)OC(=O)Cl.CNCCOC>>COCCN(C)C(=O)OC(C)Cl,,ClCCl,ClCCl,c1ccncc1,,val
US20040082571A1,BrBr.COc1cccc(N2CCNCC2)c1.Cl>>COc1cc(N2CCNCC2)ccc1Br.Cl,,CC(=O)O,O,Cl,CC(=O)[O-].[Na+],val
US03976635,CCOC(=O)C(C#N)=NOC(=O)OCC(C)C.O=C(O)CNC(=O)OCc1ccccc1>>CC(C)COC(=O)CNC(=O)OCc1ccccc1,,C1CCOC1,,CCN(CC)CC,,val
US05459142,COC(=O)[C@H](Cc1cc(OC)c(OC)c(OC)c1)NC(=O)C(CC(C)C)=NO>>COc1cc(C[C@H](NC(=O)C(CC(C)C)=NO)C(=O)O)cc(OC)c1OC,,CCO,,[Na+].[OH-],,val
US20100311755A1,C[Si](C)(C)Oc1cnnc(O[Si](C)(C)C)n1.ClCCCCBr>>O=c1cnn(CCCCCl)c(=O)[nH]1,II,CC(Cl)Cl,,CO,,val
US20030045558A1,CC(C)(Oc1ccc(O)cc1-c1ccccc1)C(=O)O.Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccc(-c4ccccc4)cc3)oc2C)cc1>>Cc1oc(-c2ccc(-c3ccccc3)cc2)nc1CCOc1ccc(OC(C)(C)C(=O)O)c(-c2ccccc2)c1,,CCO,,,,val
US20120316165A1,CC(C)(C)OC(=O)N1CCOC(c2ccc(NC(=O)Nc3cccc(C#N)c3)c(C#N)c2)C1>>N#Cc1cccc(NC(=O)Nc2ccc(C3CNCCO3)cc2C#N)c1,,CC#N,O,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20100035756A1,CCOC(=O)c1ccc(C(F)(F)F)c(O)n1.O=P(Br)(Br)Br>>CCOC(=O)c1ccc(C(F)(F)F)c(Br)n1,,CCOC(C)=O,,CN(C)C=O,O,val
US20040235822A1,CCI.O=Cc1ccc([N+](=O)[O-])c(O)c1>>CCOc1cc(C=O)ccc1[N+](=O)[O-],,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060194837A1,COc1ccc(C2CN(C)Cc3cc(C#CCCOS(C)(=O)=O)ccc32)cc1.FC1(F)CCNCC1>>COc1ccc(C2CN(C)Cc3cc(C#CCCN4CCC(F)(F)CC4)ccc32)cc1,,CCO,O,Cl,,val
US20140163219A1,CC(C)C(=O)Nc1nc(CO)cs1>>CC(C)C(=O)Nc1nc(C=O)cs1,O=[Mn]=O,C1CCOC1,,,,val
US20120283256A1,Clc1ccc2c(Cl)ccnc2c1.Nc1ccc(CN2CCOCC2)c(O)c1>>Oc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1CN1CCOCC1,,CCO,,,,val
US20080081812A1,CON(C)C(=O)CNC(=O)OC(C)(C)C.Cl[Mg]C1CCCCC1>>CC(C)(C)OC(=O)NCC(=O)C1CCCCC1,,C1CCOC1,,,,val
US20050261272A1,FC(F)(F)C1CCNCC1.O=C(N[C@@H](Cc1ccc(F)cc1)C(=O)O)c1cc2cc(Cl)ncc2[nH]1>>O=C(N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(F)(F)F)CC1)c1cc2cc(Cl)ncc2[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090186879A1,CCOC(=O)Cn1c(=O)[nH]c2cccc(C(CC)CC)c21.O=C1CCC(=O)N1Cl>>CCOC(=O)Cn1c(=O)[nH]c2c(Cl)ccc(C(CC)CC)c21,,Clc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20110071175A1,COC(=O)Cn1c(C)c(Cc2sccc2S(=O)(=O)c2ccccc2)c2cc(Cl)ccc21>>Cc1c(Cc2sccc2S(=O)(=O)c2ccccc2)c2cc(Cl)ccc2n1CC(=O)O,,C1CCOC1,,Cl,[Li+].[OH-],val
US20100256127A1,CCCCc1noc(CO)c1COc1ccc(C(=O)O)cn1.NC1CCC1>>CCCCc1noc(CO)c1COc1ccc(C(=O)NC2CCC2)cn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US06479512B1,CCOC(=O)CC(=O)OCC.O=Cc1ccc(Cl)cc1[N+](=O)[O-]>>CCOC(=O)c1cc2ccc(Cl)cc2[nH]c1=O,[Pd],CCO,,C1CCNCC1,,val
US20090105253A1,CCNC(=O)c1ccc(-n2nnc(C(=O)NC3CC3)c2CO)c(O)c1>>CCNC(=O)c1ccc2c(c1)OCc1c(C(=O)NC3CC3)nnn1-2,,C1CCOC1,CCOC(C)=O,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20070299087A1,NC(c1ccncc1)c1ccc(F)c(Br)c1.S=C(Oc1ccccn1)Oc1ccccn1>>Fc1ccc(C(N=C=S)c2ccncc2)cc1Br,,ClCCl,,,,val
US20070254866A1,COc1c(F)c(F)c(N)c2c(=O)c(C(=O)O)cn(C)c12.NCCNc1ccccn1>>COc1c(NCCNc2ccccn2)c(F)c(N)c2c(=O)c(C(=O)O)cn(C)c12,,CS(C)=O,,CCN(CC)CC,,val
US05672617,CCOC(=O)CCC1CCCCC1.CCOC=O>>CCOC(=O)C(C=O)CC1CCCCC1,,CN(C)C=O,,Cl,[H-].[Na+],val
US05650410,CC(C)(C)N.COc1ccc(-c2nc(CCl)nc3cc(OC)c(OC)cc23)cc1OC>>COc1ccc(-c2nc(CNC(C)(C)C)nc3cc(OC)c(OC)cc23)cc1OC,,ClCCl,,,,val
US20100204265A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.Fc1cccnc1Br>>CC(C)(C)OC(=O)N1CCC(O)(c2ncccc2F)CC1,,C1CCOC1,,[Li]CCCC,,val
US06166020,NC(=NO)c1ccccc1.O=C(Cl)CCl>>ClCc1nc(-c2ccccc2)no1,,Cc1ccccc1,,CCN(CC)CC,,val
US04795755,FC(F)(F)CN=C=S.Nc1ccn(CCO)n1>>OCCn1ccc(NC(=S)NCC(F)(F)F)n1,,CC#N,,,,val
US20070254868A1,COc1ccc(CN)cc1.Clc1cccc(-n2ccnc2-c2cc(Br)cnc2Cl)c1Cl>>COc1ccc(CNc2ncc(Br)cc2-c2nccn2-c2cccc(Cl)c2Cl)cc1,,C1COCCO1,CCOC(C)=O,,,val
US20050107412A1,O=C(O)[C@@H]1CCCN1[N+](=O)[O-]>>[O-]c1on[n+]2c1CCC2,,CCOCC,,O=C(OC(=O)C(F)(F)F)C(F)(F)F,,val
US20110183998A1,CC(=O)NCCc1ccc(O)cc1.Clc1ccc(OC2CCCC2)cn1>>CC(=O)NCCc1ccc(Oc2ccc(OC3CCCC3)cn2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080221134A1,C#CCn1c(=O)c2c(nc(C#Cc3cccc(O)c3)n2C)n(C)c1=O.CC(=O)OC(C)=O>>C#CCn1c(=O)c2c(nc(C#Cc3cccc(OC(C)=O)c3)n2C)n(C)c1=O,,O=C([O-])O,[Na+],,,val
US04659516,CCCC(=O)Cl.CCCCN(CC)C(=O)CCCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3O)[C@@H]21>>CCCCN(C)C(=O)CCCCCCCCCC[C@@H]1Cc2cc(OC(=O)CCC)ccc2[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3O)[C@@H]21,,C1CCOC1,,CCOC(C)=O,[H-].[Na+],val
US20130216475A1,C#CCBr.OCCOCCOCCOCCOCCOCCO>>C#CCOCCOCCOCCOCCOCCOCCO,,C1CCOC1,,[H-].[Na+],,val
US20090156804A1,O=C(Cl)CCl.O[C@H](CNCc1ccccc1)c1ccc(F)cc1>>O=C(CCl)N(Cc1ccccc1)C[C@@H](O)c1ccc(F)cc1,,ClCCl,,[Na+].[OH-],,val
US20100304040A1,C=COC(C)=O.O=C(O)CCCc1ccc2ccc3cccc4ccc1c2c34>>C=COC(=O)CCCc1ccc2ccc3cccc4ccc1c2c34,,Cc1ccccc1,,,,val
US20150203489A1,Nc1ccc(-c2nc(N3CCOCC3)c3ncc(Cl)cc3n2)cc1.Nc1ccc(CO)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)c4ncc(Cl)cc4n3)cc2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20100310512A1,C=C1CCC1.CCOC(=O)/C(Cl)=N/O>>CCOC(=O)C1=NOC2(CCC2)C1,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20150232435A1,CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.COc1ccc2c(c1)CNC2.O=C(n1ccnc1)n1ccnc1>>COc1ccc2c(c1)CN(C(=O)NCCCCN1CCN(c3cc(C(F)(F)F)nc(C(C)(C)C)n3)CC1)C2,,CO,ClC(Cl)Cl,,,val
US20090181942A1,C=CCOC(=O)C[C@H]1S[C@H](c2c(OC)cccc2OC)c2cc(Cl)ccc2NC1=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>C=CCOC(=O)C[C@H]1S[C@H](c2c(OC)cccc2OC)c2cc(Cl)ccc2NC1=S,,Cc1ccccc1,,,,val
US20050148604A1,CN1CCC(=O)CC1.COc1cc(Br)ccc1-c1nc2c(C)nn(C3CCCCC3)c2c(=O)[nH]1>>COc1cc(C2(O)CCN(C)CC2)ccc1-c1nc2c(C)nn(C3CCCCC3)c2c(=O)[nH]1,,O,,C1CCOC1,[Li]CCCC,val
US20090142297A1,CN(C)C=O.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.O=C(Cl)Cc1ccc(Cl)cc1>>CC1(N2Cc3cc(CNC(=O)Cc4ccc(Cl)cc4)ccc3C2=O)CCC(=O)NC1=O,,CN(C)C=O,O,CCN(CC)CC,Cl,val
US20160185752A1,CC(C)(C)OC(=O)N1CCCC(c2ccccc2C(=O)O)C1.N>>CC(C)(C)OC(=O)N1CCCC(c2ccccc2C(N)=O)C1,,C1CCOC1,,,,val
US20090286778A1,CC(C)(C)OC(=O)Nc1ccnc(C#Cc2cccc(N)c2)c1>>CC(C)(C)OC(=O)Nc1ccnc(/C=C\c2cccc(N)c2)c1,[Pd],CO,,,,val
US20100261728A1,FC(F)(F)c1ccc(C2=NCCc3c(Br)cccc32)cc1>>FC(F)(F)c1ccc(C2NCCc3c(Br)cccc32)cc1,,O,,CO,[BH4-].[Na+],val
US20140350019A1,Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)OC(C)C)c2C)c1C>>Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1C,,C1CCOC1,CO,[Na+].[OH-],,val
US20100135999A1,CCCCOC(=O)N1CCN(C(=O)[C@@H](N)CF)CC1.Cc1ccc2c(OCC(=O)N3CCN(C(=O)OC(C)(C)C)CC3)cc(C(=O)O)nc2c1>>CCCCOC(=O)N1CCN(C(=O)[C@H](CF)NC(=O)c2cc(OCC(=O)N3CCN(C(=O)OC(C)(C)C)CC3)c3ccc(C)cc3n2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090131458A1,CCCCOc1nc(N)c2nc(OC)n(CCCCC3CCCOC3)c2n1>>CCCCOc1nc(N)c2[nH]c(=O)n(CCCCC3CCCOC3)c2n1,,CO,,C1COCCO1,Cl,val
US20120178748A1,Cc1cc(C)c(S(=O)(=O)ON)c(C)c1.Cc1ccc(C)c(N)n1>>Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1.Cc1ccc(C)n(N)c1=[NH2+],,ClCCl,,,,val
US04764458,CC(=O)OC(C)=O.CCOC(=O)CC(=O)c1ccc(N)cc1.NN>>CC(=O)Nc1ccc(C2=NNC(=O)C2)cc1,,CC#N,,O,,val
US20100056553A1,C1CCOC1.C=CC(=O)OC.CO.C[O-].N#CCc1ccc(F)cc1>>COC(=O)C1CC(C#N)(c2ccc(F)cc2)CCC1=O,,CO,,Cl,,val
US20080081910A1,OCC1CCc2[nH]c3ccc(F)cc3c2C1>>O=CC1CCc2[nH]c3ccc(F)cc3c2C1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US06670388B1,C=CCOc1ccc2[nH]c(C(=O)OCC)cc2c1.OCCc1ccsc1>>C=CCOc1ccc2c(c1)cc(C(=O)OCC)n2CCc1ccsc1,,C1CCOC1,,CCCCP(CCCC)CCCC,,val
US20120129842A1,COc1cc(N)c2ncccc2c1.O=C(N=C=S)c1ccccc1>>COc1cc(NC(N)=S)c2ncccc2c1,,CC(C)=O,,,,val
US20100179138A1,COc1ccc(-c2c(C)noc2-c2cc(Br)c(OCc3ccccc3)cc2OCc2ccccc2)cc1.OB(O)c1ccccc1>>COc1ccc(-c2c(C)noc2-c2cc(-c3ccccc3)c(OCc3ccccc3)cc2OCc2ccccc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCCCCC,CCOC(C)=O,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US04814488,COC(=O)c1ccc(O)cc1>>COC(=O)C1CCC(=O)CC1,,CC(C)O,,[H][H],,val
US20080112951A1,C=CCO[C@@H]1O[C@@H](C)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@H]1O[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1NC(C)=O>>CC(=O)N[C@H]1[C@H](O[C@H]2[C@H](O)O[C@@H](C)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,C1CCOC1,,,,val
US20050267146A1,COC(=O)CC(=O)OC(C)(C)C.N#Cc1cc(C(F)(F)F)cnc1Cl>>COC(=O)C(C(=O)OC(C)(C)C)c1ncc(C(F)(F)F)cc1C#N,,C1CCOC1,,[H-].[Na+],,val
US20010044452A1,Cn1cccc1.O=C(Cl)CCl>>Cn1cccc1C(=O)CCl,,C1CCOC1,,,,val
US20050131017A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccc(-c2ccccn2)cc1)N(Cc1ccccc1)Cc1ccccc1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccc(-c2ccccn2)cc1)N(Cc1ccccc1)Cc1ccccc1,,COC(C)(C)C,,O=C([O-])[O-].[K+].[K+],,val
US20100286123A1,COc1cc(CCO)ccc1C#N>>COc1cc(CC=O)ccc1C#N,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20160031871A1,O=C(O)c1cnc(NC2CC2)s1.c1ccc(C2CCNCC2)cc1>>O=C(c1cnc(NC2CC2)s1)N1CCC(c2ccccc2)CC1,,ClCCl,,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(CC)CC,val
US05580872,O=C([O-])CC(CC(=O)[O-])c1ccc([N+](=O)[O-])cn1>>Cc1ccc([N+](=O)[O-])cn1,,O=S(=O)(O)O,,[Na+].[OH-],,val
US20060025597A1,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=Cc1ccco1>>O=C1CCC(N2C(=O)c3cccc(NCc4ccco4)c3C2=O)C(=O)N1,,CC(=O)O,,[BH4-].[Na+],,val
US20050020645A1,Nc1ccc(Cl)nn1.O=C(Cl)CCl>>O=C(CCl)Nc1ccc(Cl)nn1,,CN(C)C=O,,,,val
US05516806,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1NC2CCC1C2>>CC(C)(C)OC(=O)N1C(=O)C2CCC1C2,CN(C)c1ccncc1,C1CCOC1,,,,val
US04482723,CC(=N)N.CC(=O)C(Cl)C1OCCO1>>CC(=O)c1c[nH]c(C)n1,,CC(C)(C)O,,Cl,CC(=O)[O-].[Na+],val
US20020169200A1,BrC(Br)=Cc1ccc2c(c1)OCO2>>C#Cc1ccc2c(c1)OCO2,,C1CCOC1,,[Li]CCCC,,val
US20130237537A1,CCCCN.Nc1ncc2c(n1)CCN(c1cccc(C(=O)O)c1)C2>>CCCCNC(=O)c1cccc(N2CCc3nc(N)ncc3C2)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06599917B1,C#C[C@@]1(O)CN2CCC1CC2.CO[C@@H]1CN(c2ccc(I)c(Cc3ccccc3)n2)C[C@H]1O>>CO[C@@H]1CN(c2ccc(C#C[C@@]3(O)CN4CCC3CC4)c(Cc3ccccc3)n2)C[C@H]1O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,CCN(CC)CC,,val
US04456604,C1CNCCN1.[O-][n+]1cccc(F)c1Cl>>[O-][n+]1cccc(F)c1N1CCNCC1,,CCCCO,,,,val
US20040138277A1,CCCCC(Cc1ccc(O)cc1)(Oc1ccccc1)C(=O)OCC.Cc1ccc(S(=O)(=O)OCCc2nc(-c3cccc(-c4ccccc4)c3)oc2C)cc1>>CCCCC(Cc1ccc(OCCc2nc(-c3cccc(-c4ccccc4)c3)oc2C)cc1)(Oc1ccccc1)C(=O)O,,CCO,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20140051677A1,CC(Cl)c1ccc(Br)cc1.CS(=O)(=O)N1CCNCC1>>CC(c1ccc(Br)cc1)N1CCN(S(C)(=O)=O)CC1,,CC#N,,CCN(C(C)C)C(C)C,,val
US05904877,CCCCCCCCBr.CCCCCCCCC1CCc2cc(-c3ccc(O)cc3)nc(F)c2C1(F)F>>CCCCCCCCOc1ccc(-c2cc3c(c(F)n2)C(F)(F)C(CCCCCCCC)CC3)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20130261141A1,FC(F)(F)c1cccc(Cl)n1.c1cncc(-c2nc[nH]n2)c1>>FC(F)(F)c1cccc(-n2cnc(-c3cccnc3)n2)n1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100197674A1,CCOC(=O)c1nc2ccccc2n(COCC(F)(F)F)c1=O>>O=C(O)c1nc2ccccc2n(COCC(F)(F)F)c1=O,,CCO,O,[Li+].[OH-],,val
US20140296200A1,CCOC(=O)Cc1ccc(Br)cc1.N#C[Cu]>>CCOC(=O)Cc1ccc(C#N)cc1,[Cu]I,CN1CCCC1=O,,,,val
US20080027084A1,CC(=O)N[C@@H]1C[C@H](NC(=O)OC(C)(C)C)CC[C@@H]1N1CC[C@H](NC(=O)OCc2ccccc2)C1=O>>CC(=O)N[C@@H]1C[C@H](N)CC[C@@H]1N1CC[C@H](NC(=O)OCc2ccccc2)C1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20020177599A1,C=CCC(N)C(=O)O.CCC(=O)OC(=O)CC>>C=CCC(NC(=O)CC)C(=O)O,,O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20110172247A1,CC(C)(C)OC(=O)Nc1cncc(Oc2cncnc2)c1.Cl>>Cl.Nc1cncc(Oc2cncnc2)c1,,C1COCCO1,,,,val
US20080262229A1,CCN(CC)C(=O)c1ccc(C(O)c2ccc(Br)cc2)cc1.O=S(Br)Br>>CCN(CC)C(=O)c1ccc(C(Br)c2ccc(Br)cc2)cc1,,ClCCl,,,,val
US20100048636A1,CCOC(=O)CO[C@@](C)(c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1>>CCOC(=O)CO[C@@](C)(c1cccc(Cl)c1)[C@@H]1CCCNC1,,CC#N,,,,val
US20130131055A1,CC1=C(C#N)C(c2cc3c(NC(=O)c4ccccc4)nccc3o2)C(C#N)=C(C)N1.CI>>CC1=C(C#N)C(c2cc3c(NC(=O)c4ccccc4)nccc3o2)C(C#N)=C(C)N1C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150099771A1,COC(=O)CBr.OC(Cc1cccnc1Br)c1ccccc1>>COC(=O)COC(Cc1cccnc1Br)c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20030073712A1,COCOc1ccc(CO)cc1Br.O=S(Cl)Cl>>COCOc1ccc(CCl)cc1Br,,ClCCl,,c1ccncc1,,val
US20020099215A1,CC(C)(C)OC(=O)N[C@@H](Cc1cccnc1)C(=O)NC(CCCc1ccccc1)CCCc1ccccc1>>N[C@@H](Cc1cccnc1)C(=O)NC(CCCc1ccccc1)CCCc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20030060466A1,Cc1nc(Cl)c(C#N)nc1-c1ccccc1.Fc1ccc(C2CCNCC2)cc1>>Cc1nc(N2CCC(c3ccc(F)cc3)CC2)c(C#N)nc1-c1ccccc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20150376136A1,CN1C(=O)NC(=O)C1(C)C1CCCCC1.Cn1cc(C(=O)CBr)cn1>>CN1C(=O)N(CC(=O)c2cnn(C)c2)C(=O)C1(C)C1CCCCC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120108587A1,CN(C)/C=C/c1nc(Oc2ccc(F)cc2F)ccc1C#N.O>>N#Cc1ccc(Oc2ccc(F)cc2F)nc1C=O,,C1CCOC1,,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20110218192A1,CNO.N#C/N=C1\CC(C2CCCOC2)Oc2ccc(Br)cc21>>CN1OC2(CC(C3CCCOC3)Oc3ccc(Br)cc32)N=C1N,,CO,,Cl,C[O-].[Na+],val
US20060052416A1,Cc1c(C(=O)CBr)cnn1-c1ccccc1.NC(=S)NCCCN1CCOCC1.O=C(Cl)c1cccs1>>Cc1c(-c2csc(N(CCCN3CCOCC3)C(=O)c3cccs3)n2)cnn1-c1ccccc1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20030114469A1,CCO.Cn1c(=O)cc(N)n(Cc2cccc([N+](=O)[O-])c2)c1=O.NC(=O)NCc1cccc([N+](=O)[O-])c1>>CC(=O)O.Cn1c(=O)cc(N)n(Cc2cccc(N)c2)c1=O,[Pd],CCO,,,,val
US20090291079A1,CCCC[Sn](CCCC)(CCCC)C1CCC=CO1.Clc1nc(Cl)nc(N2CCOCC2)n1>>Clc1nc(C2=CCOCC2)nc(N2CCOCC2)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,,,val
US20030012980A1,Cc1ccc2nc(C)cc(Br)c2c1.N#C[Cu]>>Cc1ccc2nc(C)cc(C#N)c2c1,,CN(C)C=O,,,,val
US20040147535A1,Nc1cc(CNc2ccccc2C(=O)Nc2cccc(C(F)(F)F)c2)ccn1.O=C(Cl)CCC(=O)Cl>>O=C(Nc1cccc(C(F)(F)F)c1)c1ccccc1NCc1ccnc(N2C(=O)CCC2=O)c1,,ClCCl,ClCCl,CCN(CC)CC,,val
US20070120112A1,COc1ccc(-c2nc3cccc(Nc4ccc([N+](=O)[O-])cc4)c3nc2-c2ccc(OC)cc2)cc1>>COc1ccc(-c2nc3cccc(Nc4ccc(N)cc4)c3nc2-c2ccc(OC)cc2)cc1,,C1CCOC1,,,,val
US20100168087A1,CC(=O)NN.O=S(=O)(Cl)c1c(C2OCCO2)ccc(Cl)c1Cl>>CC(=O)NNS(=O)(=O)c1c(C2OCCO2)ccc(Cl)c1Cl,,CC(C)O,,,,val
US05494925,CC(C)C1NS(=O)(=O)N(Cc2ccccc2)C1=O.CI>>CC(C)C1C(=O)N(Cc2ccccc2)S(=O)(=O)N1C,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20060172988A1,BrCCOC1CCCCO1.Cc1cc(F)ccc1CC#N>>Cc1cc(F)ccc1C(C#N)CCOC1CCCCO1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US05140029,CCN(CC)CC.O=C(Cl)c1ccccc1>>NC(=O)c1ccccc1,,ClCCl,,,,val
US20070244103A1,COc1ccc2ncc(Cl)c(C(=O)CBr)c2n1>>COc1ccc2ncc(Cl)c(C3CO3)c2n1,,CO,O,[BH4-].[Na+],,val
US20010047006A1,CC(C)(C)OC(=O)Cn1cccc(NC(=O)OCc2ccccc2)c1=O>>O=C(O)Cn1cccc(NC(=O)OCc2ccccc2)c1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04344963,CC1(C)C(C=C(c2ccccc2)C(F)(F)F)C1C(=O)O.O=S(Cl)Cl>>CC1(C)C(C=C(c2ccccc2)C(F)(F)F)C1C(=O)Cl,,ClC(Cl)(Cl)Cl,,,,val
US20070191420A1,CC(=NO)c1ccc(C(=O)O)s1>>CC(N)c1ccc(C(=O)O)s1,[Zn],CC(=O)O,,,,val
US20100305096A1,CC(C)(C)OC(=O)N1CCNCC1(C)C.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCN(C(=O)OC(C)(C)C)C(C)(C)C3)n(C)c2n1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090306078A1,COC(=O)c1ccc2[nH]c(COc3ccc(Cl)cc3Cl)nc2c1.NN>>NNC(=O)c1ccc2[nH]c(COc3ccc(Cl)cc3Cl)nc2c1,,CCOC(C)=O,,O,O,val
US20090156603A1,N#Cc1ccc(Oc2cc(Br)cnc2NC(=S)NC(=O)c2ccccc2)cc1>>N#Cc1ccc(Oc2cc(Br)cnc2NC(N)=S)cc1,,CO,,[Na+].[OH-],,val
US20160126478A1,N#Cc1c(F)c(F)c(Br)c(F)c1F.OB(O)c1ccc(C(F)(F)F)cc1>>N#Cc1c(F)c(F)c(-c2ccc(C(F)(F)F)cc2)c(F)c1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040034011A1,CCCCCCCCCCCCCCCC(=O)Cl.COc1cc2ccccc2cc1OC>>CCCCCCCCCCCCCCC(=O)c1ccc2cc(OC)c(OC)cc2c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20090105257A1,Nc1ccc([C@@H]2C[C@H]2C(=O)O)cc1.O=Cc1ccc(-c2ccccn2)cc1>>O=C(O)[C@@H]1C[C@H]1c1ccc(NCc2ccc(-c3ccccn3)cc2)cc1,,CC(Cl)Cl,ClCCl,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20090143355A1,CC(C)(C)c1ccccc1N.CN(CCCl)CCCl>>CN1CCN(c2ccccc2C(C)(C)C)CC1,,COCCOCCOC,,[I-].[K+],O=C([O-])O.[Na+],val
US05206240,CC(=O)c1cc(S(=O)(=O)Cl)ccc1O.CN>>CNS(=O)(=O)c1ccc(O)c(C(C)=O)c1,,CC#N,,,,val
US20130231329A1,CN1CCC(OC(c2cccc(C#C[Si](C)(C)C)c2)c2nc3ccccc3[nH]2)CC1>>C#Cc1cccc(C(OC2CCN(C)CC2)c2nc3ccccc3[nH]2)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20070213323A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=c1cc(O)ccn1Cc1cccc(F)c1>>O=c1cc(OS(=O)(=O)C(F)(F)F)ccn1Cc1cccc(F)c1,,ClCCl,,c1ccncc1,,val
US20100204119A1,Brc1ccccc1Br.CC(C)=O>>CC(C)(O)c1ccc(Br)cc1,,C1CCOC1,O,[Li]CCCC,[Cl-].[NH4+],val
US20030099598A1,CC(Cl)Cl.Cc1ccc2c(c1)C=CC(C)(C)[NH+]2[O-]>>Cc1ccc2nc(CCl)ccc2c1,,CC(Cl)Cl,,Cc1ccc(S(=O)(=O)Cl)cc1,,val
US06087380,CCCCCCOC(=O)Cl.COC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C)c1ccccn1>>CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OC)c4ccccn4)ccc3n2C)cc1,,CO,ClCCl,Cl,,val
US20140349991A1,C=CCBr.CCC(=O)N1CCC(c2oc3cc(O)ccc3c(=O)c2C)CC1>>C=CCOc1ccc2c(=O)c(C)c(C3CCN(C(=O)CC)CC3)oc2c1,,CC(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160175284A1,COC(=O)C(C(=O)c1c(OC)ccc(OC)c1F)c1ccc(F)cc1>>COc1ccc(OC)c(C(=O)Cc2ccc(F)cc2)c1F,,CCO,Cl,,,val
US05593993,CSC(=S)Nc1ccccc1.NC(Cc1ccccc1)C(=O)O>>O=C1C(Cc2ccccc2)NC(=S)N1c1ccccc1,,CCO,,CCN(CC)CC,,val
US20160200674A1,C=C(C)CBr.O=[N+]([O-])c1cc(Br)ccc1NC1CCCCC1>>C=C(C)CN(c1ccc(Br)cc1[N+](=O)[O-])C1CCCCC1,,CN(C)C=O,,[H-].[Na+],,val
US20040180925A1,CC1(NC(=O)OC(C)(C)C)CCNCC1.FC(F)(F)c1ccc(Cl)nc1>>CC1(NC(=O)OC(C)(C)C)CCN(c2ccc(C(F)(F)F)cn2)CC1,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US20080255083A1,O=C(Cn1ccc(OCc2ccccc2)cc1=O)c1ccc2c(c1)CCN(C(=O)C(F)(F)F)CC2>>O=C(Cn1ccc(OCc2ccccc2)cc1=O)c1ccc2c(c1)CCNCC2,,CO,,[Na+].[OH-],,val
US20140315911A1,COC(=O)[C@@H](C)NC1CCCCC1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>COC(=O)[C@@H](C)N(c1nc(Cl)ncc1[N+](=O)[O-])C1CCCCC1,,CCOCC,,O=C([O-])[O-].[K+].[K+],,val
US20110105429A1,CCOC(=O)c1csc(C2CCN(C(=O)OC(C)(C)C)CC2)n1.Cl>>CCOC(=O)c1csc(C2CC[NH2+]CC2)n1.[Cl-],,CCOCC,,,,val
US20130210787A1,C=C(C)[C@@H]1CC[C@]2(NCCN(c3ccc(Cl)cn3)S(=O)(=O)C(F)(F)F)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC7(C6)CC(C(=O)OC(C)C)(C(=O)OC(C)C)C7)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(NCCN(c3ccc(Cl)cn3)S(=O)(=O)C(F)(F)F)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC7(C6)CC(C(=O)O)(C(=O)O)C7)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1COCCO1,CO,Cl,[Na+].[OH-],val
US20120283271A1,Nc1ccn(CCO)n1.O=C(O)[C@H](CC1CCCC1)N1Cc2c(cccc2C(F)(F)F)C1=O>>O=C(Nc1ccn(CCO)n1)[C@H](CC1CCCC1)N1Cc2c(cccc2C(F)(F)F)C1=O,CN(C)C=O,ClCCl,,Cc1cccc(C)n1,O=C(Cl)C(=O)Cl,val
US20070060629A1,COC(=O)Cc1cc(-c2ccc(C)cc2)n(-c2ccc(S(N)(=O)=O)cc2)n1>>Cc1ccc(-c2cc(CC(=O)O)nn2-c2ccc(S(N)(=O)=O)cc2)cc1,,CO,,[Na+].[OH-],,val
US20060257987A1,CCc1ccc(O[C@H](C)CCOc2ccc(CCC(=O)OC)c(C)c2)c(C(O)c2ccccc2)c1>>CCc1ccc(O[C@H](C)CCOc2ccc(CCC(=O)O)c(C)c2)c(C(O)c2ccccc2)c1,,CO,,,,val
US04472305,CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)OC(C)(C)C)C(N)=O.Cl>>CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN)C(N)=O.Cl,,CC(=O)O,,,,val
US20030171428A1,CC(=O)O.COc1cc(Br)c(OC)c(CC#N)c1>>COc1cc(Br)c(OC)c(CC(=O)O)c1,,O,O=S(=O)(O)O,,,val
US05491152,CCOC(=O)C(OCC)OCC.COc1ccc(CCO)cc1OC.C[Si](C)(C)OS(=O)(=O)C(F)(F)F>>CCOC(=O)C1SCCc2cc(OC)c(OC)cc21,,CC#N,,O,,val
US20080242685A1,NC(=O)c1nc(-c2ccccc2)cc2c(C3CCNCC3)c[nH]c12.O=C(Cl)c1ccccc1>>NC(=O)c1nc(-c2ccccc2)cc2c(C3CCN(C(=O)c4ccccc4)CC3)c[nH]c12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120165331A1,C#CCN.O=C(OCc1ccccc1C(=O)Cl)c1ccccc1>>C#CCNC(=O)c1ccccc1COC(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,O,val
US20090233900A1,CN1C(=O)CCc2ccc(NC(=O)c3ccc(Cl)cc3NCCO)cc21.CS(=O)(=O)Cl>>CN1C(=O)CCc2ccc(NC(=O)c3ccc(Cl)cc3NCCOS(C)(=O)=O)cc21,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080161289A1,N#Cc1ccc(-c2nc3c(s2)CCN(C(=O)C(F)(F)F)CC3)nc1>>N#Cc1ccc(-c2nc3c(s2)CCNCC3)nc1,,C1COCCO1,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20150175623A1,CN(C)C=O.COCCCn1ccnn1>>COCCCn1nncc1CO,,C1CCOC1,,O,[BH4-].[Na+],val
US20120295934A1,NCc1ccccc1.O=C1CC2CN(c3ccc(OC(F)(F)F)cc3)C(=O)C2C1>>O=C1C2CC(NCc3ccccc3)CC2CN1c1ccc(OC(F)(F)F)cc1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20070149534A1,CN(C)C=O.ClCCN1CCOCC1.Nc1cc(C2CC2)n[nH]1>>CC(C)(C)c1cc(N)n(CCO)n1,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US06586447B1,CC(C)(C)OC(=O)C(C(=O)OC(C)(C)C)c1ccc(Br)cc1N.O=CC12CC3CC(CC(C3)C1)C2>>CC(C)(C)OC(=O)C(C(=O)OC(C)(C)C)c1ccc(Br)cc1NCC12CC3CC(CC(C3)C1)C2,,CC(=O)O,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20110183975A1,CC(C)I.c1cc2cc[nH]c2cn1>>CC(C)n1ccc2ccncc21,,CN(C)C=O,,,,val
US04198420,CN1CCC2(CC1)C(=O)c1ccccc1Sc1ccccc12>>CN1CCC2(CC1)c1ccccc1Sc1ccccc1C2O,,C1CCOC1,,,,val
US03933886,CCOC(=O)CC(C)=O.Nc1ccc(N)c([N+](=O)[O-])c1>>CC(=O)CC(=O)Nc1ccc(N)c([N+](=O)[O-])c1,,Clc1ccccc1,,CCO,,val
US05023258,Nc1ccc(N2CCN(c3ccc(OCC(O)(Cn4cncn4)c4ccc(Cl)cc4Cl)cc3)CC2)cc1.O=S(=O)(Cl)CC(F)(F)F>>O=S(=O)(CC(F)(F)F)Nc1ccc(N2CCN(c3ccc(OCC(O)(Cn4cncn4)c4ccc(Cl)cc4Cl)cc3)CC2)cc1,,ClCCl,,c1ccncc1,,val
US20130029978A1,O=C1CCOc2cc(O)ccc21.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>O=C1CCOc2cc(OCC(F)(F)F)ccc21,,CC(C)=O,O,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20160009683A1,CCOC(=O)C(F)(F)Br.COCOc1ccccc1I>>CCOC(=O)C(F)(F)c1ccccc1OCOC,[Cu],CS(C)=O,,,,val
US20150336967A1,CCI.O=[N+]([O-])c1c(Br)c(Br)cc2[nH]c(Br)nc12>>CCn1c(Br)nc2c([N+](=O)[O-])c(Br)c(Br)cc21,,CC#N,,[Na+].[OH-],,val
US20040229949A1,CCCCCCI.COC(=O)C(O)Cc1ccc(OCc2ccccc2)cc1>>CCCCCCOC(Cc1ccc(OCc2ccccc2)cc1)C(=O)OC,O=[Ag-],ClCCl,,,,val
US20080233309A1,C=CCCCCCCCCOCOC.CO[SiH](OC)OC>>COCOCCCCCCCCCC[Si](OC)(OC)OC,,C1CCOC1,,CC(=O)O,,val
US20100029753A1,O=S(=O)(O)Cl.c1ccc2c(c1)CCCC2>>O=S(=O)(Cl)c1ccc2c(c1)CCCC2,,ClCCl,,,,val
US05488055,Nc1ccnn1C1CCCC1.O=C(O)c1ccccc1I>>O=C(O)c1ccccc1Nc1ccnn1C1CCCC1,,CC(=O)O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160166560A1,COc1cccc(CN2CCC(N(C)C(=O)n3cnc(-c4ccc(O)cc4)c3)CC2)c1.NS(=O)(=O)Cl>>COc1cccc(CN2CCC(N(C)C(=O)n3cnc(-c4ccc(OS(N)(=O)=O)cc4)c3)CC2)c1,,CC(=O)N(C)C,,,,val
US20060148858A1,CC(C)c1nn(-c2nnc(C(F)(F)F)s2)cc1CCCO.COC(=O)Cc1cccc(OC)c1O>>COc1cccc(CC(=O)O)c1OCCCc1cn(-c2nnc(C(F)(F)F)s2)nc1C(C)C,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20120101134A1,CCc1c(CN(C)CC(=O)OC)cccc1-c1cnc(-c2ccc(OC(C)C)c(C#N)c2)s1>>CCc1c(CN(C)CC(=O)O)cccc1-c1cnc(-c2ccc(OC(C)C)c(C#N)c2)s1,,CC(C)O,O,[Na+].[OH-],,val
US20150225427A1,CCOC(=O)c1cc([Si](C)(C)C)nn1-c1ccc(O)cc1.ClCCN1CCOCC1>>CCOC(=O)c1cc([Si](C)(C)C)nn1-c1ccc(OCCN2CCOCC2)cc1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090131423A1,CC(F)c1cc2c(cn1)C=Cc1ncc(Cl)cc1C2O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C>>CC(F)c1cc2c(cn1)C=Cc1ncc(Cl)cc1C2O,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05270302,O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OC1C2CC3CC(C2)CC1C3>>O=C(Cl)OC1C2CC3CC(C2)CC1C3,,ClCCl,,c1ccncc1,,val
US20050038081A1,Cc1ccc(C(=O)Nc2cccc(N3CCOCC3)c2)cc1NC(=O)c1cccc(OC2CCN(C(=O)OC(C)(C)C)C2)c1>>Cc1ccc(C(=O)Nc2cccc(N3CCOCC3)c2)cc1NC(=O)c1cccc(OC2CCNC2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US06756373B1,CCCOc1ncc(NC(C)C(=O)OC)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1>>CCCOc1ncc(N[C@@H](C)C(=O)O)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1,Cl,CO,O,[Na+].[OH-],,val
US20130096118A1,CN(C)/C=C/[N+](=O)[O-].NC(=O)c1ccc(Br)c2cc[nH]c12>>NC(=O)c1ccc(Br)c2c(C=C[N+](=O)[O-])c[nH]c12,,O=C(O)C(F)(F)F,,,,val
US20150080371A1,CN1CCNCC1.COc1cc(C)cc2cc(-c3c(C(=O)O)cn4ncnc(N)c34)sc12>>COc1cc(C)cc2cc(-c3c(C(=O)N4CCN(C)CC4)cn4ncnc(N)c34)sc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20110152233A1,CCN(C(=O)Oc1ccc(F)cc1)[C@@H]1CN(C(=O)C2CCNCC2)C[C@H]1c1ccc(Cl)c(F)c1.CS(=O)(=O)Cl>>CCN(C(=O)Oc1ccc(F)cc1)[C@@H]1CN(C(=O)C2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(Cl)c(F)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20100240658A1,CC(C)(C)OC(=O)CN.N#Cc1cccc(C=O)c1>>CC(C)(C)OC(=O)CNCc1cccc(C#N)c1,,Cc1ccccc1,,[BH4-].[Na+],,val
US20080015203A1,C1CCNCC1.C[C@@H](CO)Oc1cc(Oc2ccc(C(=O)O)cc2)cc(C(=O)Nc2ccn(C)n2)c1>>C[C@@H](CO)Oc1cc(Oc2ccc(C(=O)N3CCCCC3)cc2)cc(C(=O)Nc2ccn(C)n2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06242443B1,NOCc1ccccc1.O=S1(=O)N=C(Cl)Nc2ccc(Cl)cc21>>O=S1(=O)N=C(NOCc2ccccc2)Nc2ccc(Cl)cc21,,CCO,,CCN(CC)CC,Cl,val
US04245097,Br.C=CCCCCCCCCCNc1ccc(C(=O)O)cc1>>O=C(O)c1ccc(NCCCCCCCCCCCBr)cc1,,COCCOC,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20150119362A1,CCCN.O=C(O)Cc1ccc(Nc2nc(-c3cccc(Cl)c3)nc3c2S(=O)(=O)CCC3)cc1>>CCCNC(=O)Cc1ccc(Nc2nc(-c3cccc(Cl)c3)nc3c2S(=O)(=O)CCC3)cc1,,CCOC(C)=O,CN(C)C=O,ClCCCl,On1nnc2ccccc21,val
US06177440B1,C1CCOC1.C=CCOCc1cc(OCC(=O)O)c2c3c(C(N)=O)cccc3n(Cc3ccccc3)c2c1>>CCCOCc1cc(OCC(=O)OC)c2c3c(C(N)=O)cccc3n(Cc3ccccc3)c2c1,O=[Pt],,,,,val
US20040002492A1,O=c1c2ccccc2sc2c(O)ccc(Br)c12>>Oc1ccc(Br)c2c1Sc1ccccc1C2,,C1CCOC1,,B,,val
US20110230476A1,CC(C)(C)OC(=O)N1CCN(c2ccnc3ccc(C=O)cc23)CC1.O=C1CSC(=O)N1>>CC(C)(C)OC(=O)N1CCN(c2ccnc3ccc(/C=C4\SC(=O)NC4=O)cc23)CC1,,CCO,,C1CCNCC1,CC(=O)O,val
US20120295874A1,CC(C)(C)OC(=O)NCc1ccc(C(=O)O)cc1.COC(=O)CCOc1ccc(CN)cc1>>COC(=O)CCOc1ccc(CNC(=O)c2ccc(CNC(=O)OC(C)(C)C)cc2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060194841A1,CN(CC(CC(O)CO)(c1ccc(Cl)c(Cl)c1)N(C)C(=O)OC(C)(C)C)C(=O)CC(F)(F)F>>CN(CC(CC=O)(c1ccc(Cl)c(Cl)c1)N(C)C(=O)OC(C)(C)C)C(=O)CC(F)(F)F,,C1CCOC1,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20110053940A1,Cc1c(Br)cc(CN(C(=O)[C@@H]2CNCC[C@H]2c2ccn(C)c(=O)c2)C2CC2)cc1C(=O)c1cccc(F)c1>>Cc1c(Br)cc(CN(C(=O)[C@@H]2CNCC[C@H]2c2ccn(C)c(=O)c2)C2CC2)cc1C(O)c1cccc(F)c1,,CO,,[BH4-].[Na+],,val
US20030134884A1,CCOC(=O)Cl.Cc1sc(-c2ccccc2)nc1COc1ccc(CCC[C@@H](O)C(=O)O)cc1.N>>CCOC(=O)O[C@H](CCCc1ccc(OCc2nc(-c3ccccc3)sc2C)cc1)C(N)=O,,O,,C1CCOC1,CCN(CC)CC,val
US20140336376A1,CNC.Fc1cc(Br)c2sc(CBr)cc2c1F>>CN(C)Cc1cc2c(F)c(F)cc(Br)c2s1,,C1CCOC1,CC#N,,,val
US20050009820A1,CC(=O)Nc1cccc(S)c1.CCOC(=O)C1CCC(CC)CC1=O>>CCC1CCc2c(sc3cc(NC(C)=O)ccc3c2=O)C1,,CCOC(C)=O,,,,val
US20130123268A1,CC(C)(C)OC(=O)N1C2CCC1CC(O)(c1cncnc1)C2.Cl>>Cl.OC1(c2cncnc2)CC2CCC(C1)N2,,C1COCCO1,Cl,ClCCl,,val
US04697033,CCC(C)Oc1ccc(O)cc1.O=C1OCCO1>>CCC(C)Oc1ccc(OCCO)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020032186A1,C=C(C)C=CBr.CCOC(=O)CS(=O)(=O)c1ccc(OC)cc1>>CCOC(=O)C(CC=C(C)C)S(=O)(=O)c1ccc(OC)cc1,,CC(C)=O,,C1COCCOCCOCCOCCOCCO1,O=C([O-])[O-].[K+].[K+],val
US20130172323A1,ClCCN1CCOCC1.Oc1ccc(-c2nc3ccc(Br)cc3o2)cc1>>Brc1ccc2nc(-c3ccc(OCCN4CCOCC4)cc3)oc2c1,,CC#N,,Cl,,val
US04640708,CC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccc2ncccc2c1>>CC(=O)C=Cc1ccc2ncccc2c1,,CS(C)=O,,O,,val
US20090069288A1,CC(C)Oc1ccc(NC(=O)c2cc(-c3ccc(OC[C@H]4COC(C)(C)O4)cc3)on2)cc1Cl>>CC(C)Oc1ccc(NC(=O)c2cc(-c3ccc(OC[C@H](O)CO)cc3)on2)cc1Cl,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US06107307,CN1[C@H]2CC[C@@H]1CC(=O)C2.O=S(=O)(c1ccccc1)n1ccc2ccccc21>>CN1C2CCC1CC(O)(c1cc3ccccc3n1S(=O)(=O)c1ccccc1)C2,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20050245534A1,CC(=O)OC(C)=O.O=C1C2CC3CC1CC(O)(C3)C2>>CC(=O)OC12CC3CC(C1)C(=O)C(C3)C2,,ClCCl,,CN(C)c1ccccn1,,val
US20110070317A1,CC1(NC(=O)OC(C)(C)C)CCCNC1.ClCCl.O=C(Nc1c[nH]c2ncc(F)c(F)c12)c1cccnc1>>CC1(N)CCCN(c2c(F)cnc3[nH]cc(NC(=O)c4cccnc4)c23)C1.Cl,,CCCCO,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20140128392A1,CCc1ccc(-c2nc3ccc(C(=O)O)cc3nc2-c2ccc(CC)cc2)cc1.CON>>CCc1ccc(-c2nc3ccc(C(=O)NOC)cc3nc2-c2ccc(CC)cc2)cc1,,ClCCl,O=S(Cl)Cl,CCN(CC)CC,Cl,val
US20090163488A1,CC(C)(C)OC(=O)Nc1cccc(Oc2ccc3nc(N)nn3c2)c1.O=C(Cl)C1CC1>>Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)c1,,CC(=O)N(C)C,O,,,val
US20100311747A1,CN(C)C(=O)N1CC2CC(C)(NCC(=O)N3C[C@@H](F)C[C@H]3C#N)CC2C1.O=C(O)C(O)C(O)C(=O)O>>CN(C)C(=O)N1CC2CC(C)(NCC(=O)N3C[C@@H](F)C[C@H]3C#N)CC2C1.O=C(O)C(O)C(O)C(=O)O,,CC(C)=O,ClCCl,,,val
US05210092,CCCC(=O)Cl.Cc1ccnc(N)c1[N+](=O)[O-]>>CCCC(=O)Nc1nccc(C)c1[N+](=O)[O-],,CCOC(C)=O,,CN(C)c1ccccc1,,val
US20030236413A1,Brc1ccc(-n2ccnc2)cc1.c1cn[nH]c1>>c1cnn(-c2ccc(-n3ccnc3)cc2)c1,,CC#N,,,,val
US04239901,CCOC(=O)C(C)c1ccc(-n2cc(Cl)cn2)c(Cl)c1.NN>>CC(C(=O)NN)c1ccc(-n2cc(Cl)cn2)c(Cl)c1,,CN(C)C=O,,ClCCl,O,val
US20110152318A1,CC(C)(C)[Si](C)(C)Cl.CON(C)C(=O)c1cc(O)cc(C(F)(F)F)c1>>CON(C)C(=O)c1cc(O[Si](C)(C)C(C)(C)C)cc(C(F)(F)F)c1,,CCOC(C)=O,ClCCl,c1c[nH]cn1,,val
US20090023731A1,O=C(Cl)c1ccc(C(F)(F)F)cc1.O=C(Nc1cccc(OCCCN2CCOCC2)c1)C12CC3CC(CC(C3)C1)C2>>O=C(Nc1cccc(OCCCN2CCOCC2)c1)c1ccc(C(F)(F)F)cc1,,ClCCl,,CCN(CC)CC,CO,val
US06114391,COC(=O)CN.O=C1Cc2ccccc2C1>>COC(=O)CNC1CCc2ccccc21,,CCO,CO,[BH3-]C#N.[Na+],,val
US20100094000A1,CC(=O)OC(C)=O.Cc1nn(CC(F)(F)CO)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2>>CC(=O)OCC(F)(F)Cn1nc(C)c(-c2ccc3c(c2)NC(=O)CO3)c1-c1ccc(F)cc1,,CCOC(C)=O,,,,val
US20090275592A1,CC#N.COC(=O)c1ccc2cnccc2c1>>N#CCC(=O)c1ccc2cnccc2c1,,C1CCOC1,,[Li]C(C)(C)C,,val
US06413448B1,Brc1cccnc1Br.CCCCCCCCc1ccc(B(O)O)cc1>>CCCCCCCCc1ccc(-c2ccc(Br)cn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20120053173A1,CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(OC)cc3c2C)C(CC)CC)cc1>>CCC(CC)C(Nc1ccc(C(=O)N(C)CCC(=O)O)cc1)c1oc2ccc(OC)cc2c1C,,CCO,,C1CCOC1,[Na+].[OH-],val
US05688809,N#Cc1ccc2c(c1)ncn2-c1ccc2[nH]ccc2c1.O=C1CCCCC1>>N#Cc1ccc2c(c1)ncn2-c1ccc2[nH]cc(C3=CCCCC3)c2c1,,CN(C)C=O,,C[O-].[Na+],,val
US05556864,CN1CCCC1CCOc1ccccc1CCc1ccc(C#N)cc1.Cl>>CN1CCCC1CCOc1ccccc1CCc1ccc(C#N)cc1.Cl,,C1COCCO1,,,,val
US20110144105A1,CC(C)(O)c1ccc(C(=CC2CCCC2)c2cc3cccnc3[nH]2)cc1>>CC(C)(O)c1ccc(C(CC2CCCC2)c2cc3cccnc3[nH]2)cc1,[Pd],CO,,,,val
US20100022585A1,CN(C)C=O.Cc1cc([N+](=O)[O-])ccc1C(=O)O>>Cc1cc([N+](=O)[O-])ccc1C(N)=O,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20160221972A1,CCOC(=O)c1ccc2c(c1)[C@@H](C)N(Cc1ccc(OC)cc1)CCO2.NO>>COc1ccc(CN2CCOc3ccc(C(=O)NO)cc3[C@H]2C)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US05446044,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1cccc(C2CCN(Cc3ccccc3)C2)c1>>CC(C)(C)OC(=O)NCc1cccc(C2CCN(Cc3ccccc3)C2)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060009511A9,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Oc1cccc(CNCCc2cccc(Cl)c2)c1>>CC(C)(C)OC(=O)N(CCc1cccc(Cl)c1)Cc1cccc(O)c1,,O,,CCN(CC)CC,ClCCl,val
US20060148858A1,CCOC(=O)CCc1ccc(O)c(OC)c1.CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO>>CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1ccc(CCC(=O)O)cc1OC,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20120264748A1,Cc1ccc(S(=O)(=O)n2cc(CN3CCCC4(CCN(c5cnc6ccccc6c5)CC4)C3=O)c3ccccc32)cc1>>O=C1N(Cc2c[nH]c3ccccc23)CCCC12CCN(c1cnc3ccccc3c1)CC2,,CCOC(C)=O,CO,O=C([O-])[O-].[Cs+].[Cs+],,val
US04328244,ClCc1ccc(Cl)cc1Cl.Nc1ccc(S(=O)(=O)O)cc1>>O=S(=O)(O)c1ccc(NCc2ccc(Cl)cc2Cl)cc1,,CC#N,O,Cl,CC(=O)[O-].[Na+],val
US20160107989A1,CCOC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)OCC>>CCOC(=O)C(Cc1ccc(O)cc1)OCC,[Pd],CCN(CC)CC,,CCO,,val
US05472964,Cc1nc2ccc(COS(C)(=O)=O)nc2s1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CS(=O)(=O)[O-].Cc1nc2ccc(C[P+](c3ccccc3)(c3ccccc3)c3ccccc3)nc2s1,,CC#N,,,,val
US06413995B1,CCOC(=O)C(F)(F)F.Nc1ccc(C=CC(=O)O)cc1>>O=C(O)C=Cc1ccc(NC(=O)C(F)(F)F)cc1,,CO,,CCN(CC)CC,Cl,val
US03935182,C[N+](C)(CCCNC=O)CC(=O)Nc1ccc([N+](=O)[O-])cc1.[Cl-]>>C[N+](C)(CCCN)CC(=O)Nc1ccc([N+](=O)[O-])cc1.[Cl-],,O,,Cl,[Na+].[OH-],val
US20140296136A1,CC(C)(O)C1(S(=O)(=O)NC(=O)OCc2ccccc2)CC1>>CC(C)(O)C1(S(N)(=O)=O)CC1,[Pd],CO,,,,val
US20110288133A1,CC(C)(C)OC(=O)NC(Cc1ccc(OCc2ccccc2)cn1)C(=O)O.COC(=O)c1ccc(CN)cc1>>COC(=O)c1ccc(CNC(=O)C(Cc2ccc(OCc3ccccc3)cn2)NC(=O)OC(C)(C)C)cc1,,ClCCl,,,,val
US20100184739A1,CC(C)(C)c1ccccc1N.O=C1CCC(=O)O1>>CC(C)(C)c1ccccc1NC(=O)CCC(=O)O,,Cc1ccccc1,,,,val
US05484774,CC(=O)OC[C@H]1O[C@@H](n2cnc3c(N[C@H](C)CSc4n[nH]c(-c5ccccc5)n4)nc(Cl)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@@H](n2cnc3c(N[C@H](C)CSc4n[nH]c(-c5ccccc5)n4)nc(Cl)nc32)[C@H](O)[C@@H]1O,,CO,,C[O-].[Na+],,val
US05719182,CCCOc1ccc2c(c1)C(c1ccc(OC)cc1Oc1cnccc1C=O)C(C(=O)OC)C2c1ccc2c(c1)OCO2.NS(=O)(=O)O>>CCCOc1ccc2c(c1)C(c1ccc(OC)cc1Oc1cnccc1C(=O)O)C(C(=O)OC)C2c1ccc2c(c1)OCO2,,CC(C)(C)O,O,[Na+].[O-]Cl,,val
US06683211B1,C#CCOc1ccc(CCN(O)C(=O)Cc2ccc(Cl)cc2)cc1OC.CS(=O)(=O)Cl>>C#CCOc1ccc(CCN(OS(C)(=O)=O)C(=O)Cc2ccc(Cl)cc2)cc1OC,,ClCCl,,CCN(CC)CC,,val
US20100286145A1,C=C(C)c1cc(C#N)cc(NC(C)=O)c1>>CC(=O)Nc1cc(CN)cc(C(C)C)c1,,CCO,,Cl,[BH4-].[Na+],val
US20150284411A1,CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@H]12.C[Si](C)(C)CCOCn1c(S)nc2nc(-c3ccc(-c4ccccc4)cc3)c(Cl)cc21>>O[C@@H]1CO[C@@H]2[C@H](Sc3nc4nc(-c5ccc(-c6ccccc6)cc5)c(Cl)cc4[nH]3)CO[C@@H]21,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04978476,Cc1ccc(-c2nc3ccccc3n2C(=O)C(F)(F)F)cc1.O=C1CCC(=O)N1Br>>O=C(n1c(-c2ccc(CBr)cc2)nc2ccccc21)C(F)(F)F,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20120088746A1,CCOC(=O)c1cnc2cc(C(F)(F)F)c(F)cc2c1>>O=C(O)c1cnc2cc(C(F)(F)F)c(F)cc2c1,,CCO,,Cl,[Na+].[OH-],val
US20150165026A1,CC(C)(C)OC(=O)N1CCCC1C(=O)Oc1ccccc1>>O=C(Oc1ccccc1)C1CCCN1,,ClCCl,,O=C(O)C(F)(F)F,,val
US04321384,COC(=O)/C=C(/C)N.O=C1C=C(O)CN(Cc2ccccc2)C1.O=Cc1ccccc1C(F)(F)F>>COC(=O)C1=C(C)NC2=C(C(=O)CN(Cc3ccccc3)C2)C1c1ccccc1C(F)(F)F,,CCO,,,,val
US20060276433A1,NNc1ccc(-c2cnco2)cc1.O=C(c1ccccc1)c1ccncc1>>c1ccc(C(=NNc2ccc(-c3cnco3)cc2)c2ccncc2)cc1,,CCO,,,,val
US20120128630A1,CC(=O)c1ccc(N2CCCC2)cc1.CCOC(=O)C(=O)OCC>>CCOC(=O)C(=O)CC(=O)c1ccc(N2CCCC2)cc1,,CCOC(C)=O,,C,C[O-].[Na+],val
US20030078277A1,CCOC(=O)C(C(C)=O)C(=O)OCC.Cc1cc(C)c(-c2c(C)n[nH]c2N)c(C)c1>>CCOC(=O)c1c(C)[nH]c2c(-c3c(C)cc(C)cc3C)c(C)nn2c1=O,,Cc1ccccc1C,,CC(=O)O,,val
US20140187545A1,CC(C)(C)OC(=O)Nc1n[nH]c(O)c1Cc1cccc(Cl)c1Cl.CO>>Cn1nc(NC(=O)OC(C)(C)C)c(Cc2cccc(Cl)c2Cl)c1O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05455351,CCOC(=O)c1csc(N2CCOCC2)n1>>OCc1csc(N2CCOCC2)n1,,C1CCOC1,Cc1ccccc1,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05298625,COC(=O)CC(=O)CCl.C[Si](C)(C)Cl>>COC(=O)/C=C(/CCl)O[Si](C)(C)C,,CCOC(C)=O,,CCN(CC)CC,,val
US20100204285A1,C=CCBr.CCOC(=O)c1ccc(Cl)c(O)c1>>C=CCOc1cc(C(=O)OCC)ccc1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20040014751A1,CNC.Cc1cc2c(c(Cl)n1)c(=O)cc(Nc1ccccc1)n2-c1ccccc1>>Cc1cc2c(c(N(C)C)n1)c(=O)cc(Nc1ccccc1)n2-c1ccccc1,,C1COCCO1,,,,val
US20070117816A1,CCS(=O)(=O)c1cccc(-c2cc(C(=O)O)c(C)c3[nH]c4ncc(C)cc4c23)c1.CN(C)CCN>>CCS(=O)(=O)c1cccc(-c2cc(C(=O)NCCN(C)C)c(C)c3[nH]c4ncc(C)cc4c23)c1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06040339,CCCCCC(CC(=O)Nc1cc(C(=O)O)ccc1C(C)(C)C)c1cccc2c1OCCO2.N>>CCCCCC(CC(=O)Nc1cc(C(N)=O)ccc1C(C)(C)C)c1cccc2c1OCCO2,,CC#N,,O=C(n1ccnc1)n1ccnc1,,val
US20090163709A1,COCOc1cccc(OCOC)c1.II>>COCOc1cccc(OCOC)c1I,,C1CCOC1,,[Li]CCCC,,val
US05246948,O=C1c2ccccc2C(=O)N1CSc1ccncc1>>O=C1c2ccccc2C(O)N1CSc1ccncc1,,CO,,CC(=O)O,[BH4-].[Na+],val
US04053618,CCCC(N)=S.CCOC(=O)C(Br)CC=O>>CCCc1ncc(CC(=O)OCC)s1,,CC(Cl)Cl,,O=C([O-])O.[Na+],,val
US04663336,NCC(=O)O.O=C(Cl)CCl>>O=C(O)CNC(=O)CCl,,CCOCC,,[Na+].[OH-],,val
US20160016908A1,CC(=O)N1c2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)nc2[C@H](Nc2ccccc2)[C@@H](C)[C@@H]1C1CC1>>CC(=O)N1c2ccc(N3CCNCC3)nc2[C@H](Nc2ccccc2)[C@@H](C)[C@@H]1C1CC1,,C1COCCO1,,Cl,,val
US05166213,CCCC[B+]CCCC.ClCCl.O=Cc1cccnc1.O=S(=O)([O-])C(F)(F)F>>C=CCC(CO)C(O)c1cccnc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05658858,COC(=O)c1ccc(Cl)cc1N.CS(=O)(=O)Cl>>COC(=O)c1ccc(Cl)cc1NS(C)(=O)=O,,Cl,ClCCl,CCN(CC)CC,,val
US20110201604A1,CCn1c(Nc2nc3ccc(C(F)(F)F)cc3s2)nc2cc(C(=O)O)ccc21.CN>>CCn1c(Nc2nc3ccc(C(F)(F)F)cc3s2)nc2cc(C(=O)NC)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120264735A1,O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F.O=c1ccn(-c2ccccc2)nc1Cc1cccc(O)c1>>O=c1ccn(-c2ccccc2)nc1Cc1cccc(OS(=O)(=O)C(F)(F)F)c1,,C1CCOC1,O,CCN(C(C)C)C(C)C,,val
US20140094445A1,CC(=O)c1cc(Cl)ccc1O.NNC(=O)c1cncc(Cl)c1>>C/C(=N\NC(=O)c1cncc(Cl)c1)c1cc(Cl)ccc1O,,CC(=O)O,CO,,,val
US05338739,COc1cccc(C2CCCN2)c1.ClCc1ccccc1>>COc1cccc(C2CCCN2Cc2ccccc2)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080045556A1,CCOC(=O)C1(N)CCC1.N#CSCC(=O)c1ccc(Br)cc1>>CCOC(=O)C1(Nc2nc(-c3ccc(Br)cc3)cs2)CCC1,,CCO,,CCN(CC)CC,Cl,val
US20090247567A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C(Nc1ccccc1Cl)c1cc2c(s1)-c1ccc(Br)cc1OCC2>>S=C(Nc1ccccc1Cl)c1cc2c(s1)-c1ccc(Br)cc1OCC2,,C1COCCO1,,,,val
US03976777,Cc1ccc(C(C)(C)C)c(O)c1C(=O)O.O=[N+]([O-])O>>Cc1c([N+](=O)[O-])cc(C(C)(C)C)c(O)c1C(=O)O,,CC(=O)O,,,,val
US20150051208A1,CC1(C)OB(C2=CCOCC2)OC1(C)C.O=[N+]([O-])c1ccc(Br)cc1NCc1ccccn1>>O=[N+]([O-])c1ccc(C2=CCOCC2)cc1NCc1ccccn1,,COCCOC,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04914112,CNc1nc(C(C)c2ccc(-c3ccccc3)c(F)c2)cs1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CNc1nc(C(C)c2ccc(-c3ccccc3)c(F)c2)cs1.O=C(O)CC(O)(CC(=O)O)C(=O)O,,CO,,,,val
US20130060041A1,CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.CCNC(=N)N1CC2(C=N1)CCCC2>>CCNC(=NS(=O)(=O)c1ccc(NC(C)=O)cc1)N1CC2(C=N1)CCCC2,,ClCCl,,CCN(CC)CC,Cl,val
US20030149046A1,O=C(O)c1cncc(Br)c1.c1ccc(C2=NNCC2)cc1>>O=C(c1cncc(Br)c1)N1CCC(c2ccccc2)=N1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US20070244092A1,CC(C)(C)c1nc2cc(S(=O)(=O)n3cc(C(=O)O)cn3)ccc2n1CC1CCOCC1.NCC1CC1>>CC(C)(C)c1nc2cc(S(=O)(=O)n3cc(C(=O)NCC4CC4)cn3)ccc2n1CC1CCOCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130261133A1,C=C[C@@H](C#CC#C[C@H](N)CCCCCCCCC)OC(C)=O.O=C(OC(=O)c1ccccc1)c1ccccc1>>C=C[C@@H](C#CC#C[C@@H](CCCCCCCCC)NC(=O)c1ccccc1)OC(C)=O,,ClCCl,,CCN(CC)CC,,val
US20160176850A1,CC(C)(C)OC(=O)N1CC=C(c2c[nH]c3nccnc23)CC1>>CC(C)(C)OC(=O)N1CCC(c2c[nH]c3nccnc23)CC1,[Pd],CO,,,,val
US20080004271A1,COc1cccc(-c2nc(NC3CC3)nc(O)c2C#N)c1.O=P(Cl)(Cl)Cl>>COc1cccc(-c2nc(NC3CC3)nc(Cl)c2C#N)c1,,C1COCCO1,,,,val
US20040162303A1,COc1ccc(F)c(F)c1C(=O)c1cnc(N[C@@H]2CC[C@@H](N)CC2)nc1N.OCCBr>>COc1ccc(F)c(F)c1C(=O)c1cnc(N[C@@H]2CC[C@@H](NCCO)CC2)nc1N,,C1CCOC1,,CCN(CC)CC,,val
US20090137610A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(O)Cc1cccc(Br)c1>>CC(C)(C)OC(=O)Cc1cccc(Br)c1,CN(C)c1ccncc1,CC(C)(C)O,,,,val
US20080318944A1,CON(C)C(=O)C1CN(C(=O)OC(C)(C)C)CCN1C(=O)OCc1ccccc1>>CON(C)C(=O)C1CNCCN1C(=O)OCc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20130123235A1,COC(=O)c1c(N)ccc2c1OCCc1occc1-2.O=S(=O)(Cl)c1ccc(F)cc1Br>>COC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2Br)ccc2c1OCCc1occc1-2,,ClCCl,,c1ccncc1,,val
US20130287730A1,CC(C)(C)OC(=O)N1CCC(N2CCN(C(=O)Nc3ccc(Br)c(OC(F)(F)F)c3)CC2)CC1>>O=C(Nc1ccc(Br)c(OC(F)(F)F)c1)N1CCN(C2CCNCC2)CC1,,C1COCCO1,Cl,,,val
US20080032971A1,CCN.O=[N+]([O-])c1ccc(CCl)cc1>>CCNCc1ccc([N+](=O)[O-])cc1,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US05306830,C=CCBr.COc1ccc(Br)c(O)c1>>C=CCOc1cc(OC)ccc1Br,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080009515A1,CCOC(=O)c1cnc(N)c2c(COc3cc(-c4cn(C)nn4)ccc3C)csc12.NCCO>>Cc1ccc(-c2cn(C)nn2)cc1OCc1csc2c(C(=O)NCCO)cnc(N)c12,,CS(C)=O,,,,val
US20160221972A1,COC(=O)c1ccc2c(c1)O[C@H](C)CN(c1ccccc1)C2.NO>>C[C@@H]1CN(c2ccccc2)Cc2ccc(C(=O)NO)cc2O1,,C1CCOC1,CO,[Na+].[OH-],,val
US06498164B1,O=C(Cl)Cc1ccccc1.O=C1CC(=O)N(Cc2ccccc2)C(=O)N1Cc1ccccc1>>O=C(Cc1ccccc1)C1C(=O)N(Cc2ccccc2)C(=O)N(Cc2ccccc2)C1=O,,ClCCl,,c1ccncc1,,val
US20100190763A1,CCN.O=C(O)c1ccc(N2CCN(Cc3cnc4c(c3)NC(=O)[C@@H]3CCCCN43)CC2)cc1>>CCNC(=O)c1ccc(N2CCN(Cc3cnc4c(c3)NC(=O)[C@@H]3CCCCN43)CC2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US05112966,BrCc1ccccc1.C=C(C(=O)O)[C@@H]1[C@@H]([C@@H](C)OC(=O)OCc2ccccc2)C(=O)N1C(Cc1ccc(OC)cc1)Cc1ccc(OC)cc1>>C=C(C(=O)OCc1ccccc1)[C@@H]1[C@@H]([C@@H](C)OC(=O)OCc2ccccc2)C(=O)N1C(Cc1ccc(OC)cc1)Cc1ccc(OC)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080027059A1,O=S(=O)(Cl)c1ccccc1.Oc1ccc(C2=NOC(O)(C(F)(F)F)C2)cc1>>O=S(=O)(Oc1ccc(C2=NOC(O)(C(F)(F)F)C2)cc1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20040133011A1,CCS(=O)(=O)CCC12CCC(C(=O)NC)(CC1)CC2.FC(F)(F)c1ccccc1-c1nnn[nH]1>>CCS(=O)(=O)CCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20110015202A1,CSCCl.Cc1cccc(C#Cc2cn(-c3cc[nH]c(=O)c3)c(C)n2)c1>>CSCn1ccc(-n2cc(C#Cc3cccc(C)c3)nc2C)cc1=O,,CN(C)C=O,,[H-].[Na+],,val
US20140107157A1,CS(=O)(=O)Cl.Cc1c(C(=O)N2CCC(N)CC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1>>Cc1c(C(=O)N2CCC(NS(C)(=O)=O)CC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20100286178A1,N#Cc1cnc2[nH]cc(C(=O)c3c(F)ccc(N)c3F)c2c1.O=S(=O)(Cl)N1CCCC1>>N#Cc1cnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)N4CCCC4)c3F)c2c1,,C1CCOC1,c1ccncc1,Cl,,val
US06537730B1,C=CC(SC)c1ccccc1.COS(=O)(=O)OC>>C=CC(c1ccccc1)[S+](C)C.COS(=O)(=O)[O-],,O,,c1ccccc1,,val
US05147885,CCCN1C(=O)N(N=CC(O)C2CCCCC2)C2CC(SCCCC(=O)O)CC21>>CCCN1C(=O)N(NCC(O)C2CCCCC2)C2CC(SCCCC(=O)O)CC21,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20140114068A1,CC(C)c1cc(C(C)C)c2c(c1)C1(O)C(=O)c3ccccc3C1(O)O2.O=C(Cl)C(=O)Cl>>CC(C)c1cc(C(C)C)c2c(c1)C1(Cl)C(=O)c3ccccc3C1(O)O2,CN(C)C=O,ClCCl,,,,val
US20090264445A1,CC1(C)OC[C@@H](Cn2ccc(N)n2)O1.Cc1ccccc1OC1=CC(=O)N([C@@H](CC(C)C)C(=O)O)C1>>Cc1ccccc1OC1=CC(=O)N([C@@H](CC(C)C)C(=O)Nc2ccn(C[C@@H]3COC(C)(C)O3)n2)C1,,CN(C)C=O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20070031701A1,O=C1CCC(=O)N1I.c1ccc(-n2c3ccccc3c3ccccc32)cc1>>Ic1ccc2c(c1)c1ccccc1n2-c1ccccc1,,CC(=O)O,,,,val
US20050197511A1,CO[C@H](CNC(=O)OCc1ccccc1)c1ccc(OC(C)=O)cc1>>CO[C@H](CNC(=O)OCc1ccccc1)c1ccc(O)cc1,,CCO,,Cl,[K+].[OH-],val
US20140296254A1,CCOc1c(OCC)c(=O)c1=O.Nc1cccnc1O>>CCOc1c(Nc2cccnc2O)c(=O)c1=O,,CCO,,,,val
US20110021597A1,CSCCC(O)C1CCN(C(=O)OC(C)(C)C)C1.Fc1cccc(Cl)c1Cl>>CSCCC(Oc1cccc(Cl)c1Cl)C1CCNC1,,CN(C)C=O,Cl,CCO,[H-].[Na+],val
US20110021522A1,COc1ccc(B(O)O)cn1.Nc1cccc(Br)c1>>COc1ccc(-c2cccc(N)c2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20130324573A1,C#CCN1CCCc2ccc(O)cc21.CC(C)N(C(=O)Cl)C(C)C>>C#CCN1CCCc2ccc(OC(=O)N(C(C)C)C(C)C)cc21,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20040116694A1,COc1ccc(F)cc1C(C)(C)CC1(C(F)(F)F)CO1.Nc1cccc2ncccc12>>COc1ccc(F)cc1C(C)(C)CC(O)(CNc1cccc2ncccc12)C(F)(F)F,,CCCCCC,CCOC(C)=O,,,val
US20120122842A1,Cc1ccc(S(=O)(=O)OC2CCN(C(=O)OC(C)(C)C)CC2)cc1.Nc1ccc(S)cc1>>CC(C)(C)OC(=O)N1CCC(Sc2ccc(N)cc2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080113963A1,O=C(Nc1c(OCc2ccccc2)cc(Br)cc1[N+](=O)[O-])C(F)(F)F>>On1c(C(F)(F)F)nc2c(OCc3ccccc3)cc(Br)cc21,[Ni],CCO,,,,val
US06355633B1,COC(=O)c1ccc(CS(C)(=O)=O)cc1>>CS(=O)(=O)Cc1ccc(C(=O)O)cc1,,[Na+],[OH-],Cl,,val
US05180733,COC(=O)CC(=O)Cc1ccccc1.COc1ccc2c(c1)CCC=C2C#N>>COC(=O)C(C(=O)Cc1ccccc1)C1CCc2cc(OC)ccc2C1C#N,,CC#N,,C1CCC2=NCCCN2CC1,,val
US20100130739A1,CCOC(=O)CN.Cc1cnc(Cl)nc1Cl>>CCOC(=O)CNc1nc(Cl)ncc1C,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US05298663,CCOC(OCC)[PH](=O)OCC.[Li]CCCC>>CCCC[PH](=O)C(OCC)OCC,,CCCCCC,,Cl,,val
US20030055246A1,CS(=O)(=O)Cl.OCCc1ccncc1F>>CS(=O)(=O)OCCc1ccncc1F,,ClCCl,O,CCN(CC)CC,,val
US03947470,CCN(CC)CCOc1ccc(C(=O)O)cc1.Cl.O=S(Cl)Cl>>CCN(CC)CCOc1ccc(C(=O)Cl)cc1.Cl,,ClCCl,,,,val
US20090054435A1,CC(C)[Si](Oc1ccc(Br)cc1)(C(C)C)C(C)C.COCOc1cc(OC)ccc1C=O>>COCOc1cc(OC)ccc1C(O)c1ccc(O[Si](C(C)C)(C(C)C)C(C)C)cc1,,C1CCOC1,,O,[Li]CCCC,val
US05294734,CCOC(=O)COCCCC(=O)OCc1ccccc1>>CCOC(=O)COCCCC(=O)O,[Pd],C1CCOC1,,,,val
US20140239288A1,CCCCCCOc1ccc(C#C[Si](C)(C)C)cc1>>C#Cc1ccc(OCCCCCC)cc1,,CO,,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US04073894,C=O.Cc1ccc(-n2oc(=O)[nH]c2=O)cc1>>Cc1ccc(-n2oc(=O)n(CO)c2=O)cc1,,CO,ClCCl,O,,val
US20090053142A1,CC(=O)OCC(=O)Cl.Nc1c(I)c(C(=O)Cl)c(I)c(C(=O)Cl)c1I>>CC(=O)OCC(=O)Nc1c(I)c(C(=O)Cl)c(I)c(C(=O)Cl)c1I,,CC(=O)N(C)C,,,,val
US20140128387A1,Cc1cc(N)c2c(c1Br)CCO2.OB(O)c1ccncc1>>Cc1cc(N)c2c(c1-c1ccncc1)CCO2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05075301,C1CCNCC1.CCOC(=O)c1ccc(CN2CCC(O)CC2)o1>>O=C(c1ccc(CN2CCC(O)CC2)o1)N1CCCCC1,,C1CCNCC1,,CC(=O)O,,val
US20050032786A1,COC(=O)c1ccccc1S.N#Cc1cccc(-c2ccccc2)n1>>O=c1nc(-c2cccc(-c3ccccc3)n2)sc2ccccc12,,Cc1ccccc1,,CCN(CC)CC,,val
US20080242677A1,COc1cccc(S(=O)(=O)N2CC(C(=O)O)N(c3ccccc3)C2=O)c1.Cc1ccc(C)c(N2CCNCC2)c1>>COc1cccc(S(=O)(=O)N2CC(C(=O)N3CCN(c4cc(C)ccc4C)CC3)N(c3ccccc3)C2=O)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20100239576A1,CS(=O)(=O)Cl.OCCCC1(O)CC1>>CS(=O)(=O)OCCCC1(O)CC1,,ClCCl,,CCN(CC)CC,,val
US20110028479A1,COC(OC)N(C)C.COc1ccc(C(=O)Cc2ccccc2)cc1>>COc1ccc(C(=O)C(=CN(C)C)c2ccccc2)cc1,,Cc1ccccc1,,,,val
US20060003999A1,CCC(C)(C)O.COc1cc(N)c(C#N)cc1OCCCN1CCOCC1>>COc1cc(N)c(C(N)=O)cc1OCCCN1CCOCC1,,ClCCl,,,,val
US20150299219A1,NC(=O)c1cc(Cl)ccn1.O=C(Nc1ccc(O)cn1)c1c2n(n(-c3ccccc3)c1=O)CCC2>>NC(=O)c1cc(Oc2ccc(NC(=O)c3c4n(n(-c5ccccc5)c3=O)CCC4)nc2)ccn1,,CN(C)C=O,O,CC(C)(C)[O-].[K+],,val
US20020193614A1,CCI.COC(=O)c1ccc(OC)c(O)c1>>CCOc1cc(C(=O)OC)ccc1OC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060025474A1,CCC(CC)(c1ccc(C#CC(O)C2(C)CC2)c(C)c1)c1ccc(OC[C@H]2CCC(=O)O2)c(C)c1.CO>>CCC(CC)(c1ccc(C#CC(O)C2(C)CC2)c(C)c1)c1ccc(OC[C@H](O)CCC(=O)O)c(C)c1,,C1CCOC1,,,,val
US20070179115A1,COc1cc(CN2C(=O)c3ccccc3C2=O)ccc1-c1ccccc1>>COc1cc(CN)ccc1-c1ccccc1,,ClC(Cl)Cl,,CCO,,val
US20110092539A1,COC(=O)/C=C/C(F)(F)F.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>COC(=O)c1c[nH]cc1C(F)(F)F,,CCOC(C)=O,CCOCC,CS(C)=O,[H-].[Na+],val
US06090802,CC(C)(C)OC(=O)N1CC(NC(=O)CN)C1.O=C(N=C(NC(=O)OCc1ccc([N+](=O)[O-])cc1)n1cccn1)OCc1ccc([N+](=O)[O-])cc1>>CC(C)(C)OC(=O)N1CC(NC(=O)CNC(=NC(=O)OCc2ccc([N+](=O)[O-])cc2)NC(=O)OCc2ccc([N+](=O)[O-])cc2)C1,,C1CCOC1,,CCOC(C)=O,,val
US20100125076A1,CCN(CC)CCOc1ccc(C=O)cc1.N>>CCN(CC)CCOc1ccc(CN)cc1,[Ni],CCO,,,,val
US03962441,CC(C#N)c1ccc(O)c([N+](=O)[O-])c1>>CC(C#N)c1ccc(O)c(N)c1,[Pd],CCO,,,,val
US20100240620A1,CCOC(C)=O.Cc1csc(C)n1>>CC(=O)Cc1nc(C)cs1,,C1CCOC1,,[Li]CCCC,,val
US20070167433A1,CC(C)[Si](Cl)(C(C)C)C(C)C.C[C@H](CO)CBr>>CC(C)[Si](OC[C@@H](C)CBr)(C(C)C)C(C)C,,ClCCl,,c1c[nH]cn1,,val
US06566381B1,COc1ccc(-c2ccc(S(=O)(=O)NC3CC(CNc4ccccc4)OC3=O)cc2)cc1.O>>COc1ccc(-c2ccc(S(=O)(=O)NC(CC(O)CNc3ccccc3)C(=O)O)cc2)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20090062268A1,C[C@@H](c1ccccc1)N1C[C@@H]2CCC[C@@]1(c1nc3c(C(=O)O)cccc3[nH]1)C2.N>>C[C@@H](c1ccccc1)N1C[C@@H]2CCC[C@@]1(c1nc3c(C(N)=O)cccc3[nH]1)C2,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20090318408A1,COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.Nc1ccncc1>>COc1cc(C(=O)Nc2ccncc2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20030033089A1,CNC.Clc1nc(-c2ccc3c(c2)OCO3)c2cc3c(cc2n1)OCO3>>CN(C)c1nc(-c2ccc3c(c2)OCO3)c2cc3c(cc2n1)OCO3,,CO,,,,val
US20060223801A1,Cc1[nH]c(C(=O)NC2CCNCC2)c(Cl)c1Cl.Cn1c([N+](=O)[O-])cnc1Br>>Cc1[nH]c(C(=O)NC2CCN(c3ncc([N+](=O)[O-])n3C)CC2)c(Cl)c1Cl,,CN1CCCC1=O,,CCOC(C)=O,Cl,val
US05763489,CCOC(=O)COc1cccc2c1CCC1(COC(=O)N(c3ccccc3)c3ccccc3)OC21.F>>CCOC(=O)COc1cccc2c1CCC(O)(COC(=O)N(c1ccccc1)c1ccccc1)C2F,,ClCCl,,c1ccncc1,,val
US20130082248A1,BrBr.O=C1CCCCc2ccccc21>>O=C1c2ccccc2CCCC1Br,,CCOCC,,,,val
US20100216746A1,CCOP(=O)(CC#N)OCC.C[Si](C)(C)CCOCn1cnc(Cl)c1C(=O)NCc1ccc(Cl)c(Oc2cc(Cl)cc(C=O)c2)c1F>>C[Si](C)(C)CCOCn1cnc(Cl)c1C(=O)NCc1ccc(Cl)c(Oc2cc(Cl)cc(/C=C/C#N)c2)c1F,,C1CCOC1,CCOC(C)=O,CC(C)(C)[O-].[K+],,val
US20130150341A1,CNC(=O)Nc1nc2c(s1)CN(C(=O)OC(C)(C)C)CC2>>CNC(=O)Nc1nc2c(s1)CNCC2,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20080312286A1,CC1(C2CCCC2)Cc2cc(O)c(Cl)c(Cl)c2C1=O.NC(=O)c1ccc(CBr)cc1>>CC1(C2CCCC2)Cc2cc(OCc3ccc(C(N)=O)cc3)c(Cl)c(Cl)c2C1=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060014811A1,CC(C)(C)C(=O)CC(=O)C(C)(C)C.O=C1CCC(=O)N1Br>>CC(C)(C)C(=O)C(Br)C(=O)C(C)(C)C,,ClC(Cl)(Cl)Cl,,,,val
US05840732,CCC=O.O=C1CSC(=O)N1CCCCOc1cccn2ccnc12>>CCC=C1SC(=O)N(CCCCOc2cccn3ccnc23)C1=O,,CCO,,C1CCNCC1,,val
US03983120,CCOC(=O)CNCc1c(C)cccc1N.S=C(Cl)Cl>>CCOC(=O)CN1Cc2c(C)cccc2NC1=S,,C1CCOC1,,,,val
US20140148459A1,CI.O.O=C([Na])C(CCO)SCCc1ccc(-c2ccc(Cl)cc2)cc1>>COC(=O)C(CCO)SCCc1ccc(-c2ccc(Cl)cc2)cc1,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20130150622A1,C=C[C@@H](c1cccc(OCc2ccccc2)c1)[C@@H](C)CN(C)C.Cl>>C=C[C@@H](c1cccc(OCc2ccccc2)c1)[C@@H](C)CN(C)C.Cl,,CC#N,,,,val
US20060020127A1,CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O.CCCCCCCC(=O)Cl>>CCCCCCCC(=O)OC[C@H]1O[C@H](O)[C@H](NC(C)=O)[C@@H](O)[C@@H]1O,,CN(C)C=O,,c1ccncc1,,val
US20100016319A1,C1COCCN1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2cc(Cl)nc(C)n2)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2cc(N3CCOCC3)nc(C)n2)cc1,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20080090837A1,CC(C)COC(=O)N1CCN(c2nccc(Cl)n2)CC1.CC1(C)OB(c2ccccc2C(F)F)OC1(C)C>>CC(C)COC(=O)N1CCN(c2nccc(-c3ccccc3C(F)F)n2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20050182139A1,COC(=O)C(Cl)Cl.N[C@H](CF)[C@H](O)c1ccc(S(=O)(=O)CF)cc1>>O=C(N[C@H](CF)[C@H](O)c1ccc(S(=O)(=O)CF)cc1)C(Cl)Cl,,CO,,CCN(CC)CC,,val
US20090264440A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COCCNCc1cnc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)n1C>>COCCN(Cc1cnc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)n1C)C(=O)OC(C)(C)C,,ClCCl,,,,val
US20130338140A1,CSCC[C@@H](NC(=O)OC(C)(C)C)c1ccc(Cl)c(Cl)c1.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)N[C@H](CCS(C)(=O)=O)c1ccc(Cl)c(Cl)c1,,ClCCl,,[Na+].[OH-],,val
US20130231352A1,CC(NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2c(-c2ccccn2)c1-c1ccccn1>>CC(N)c1nc2ccc(F)cc2c(-c2ccccn2)c1-c1ccccn1,,Cl,,C1COCCO1,,val
US20080207708A1,CN1CCN(c2ccc(N)c(N)c2)CC1.COC(=N)c1csc(Cc2cc(Cl)ccc2OCc2ccccc2)n1.Cl>>CN1CCN(c2ccc3[nH]c(-c4csc(Cc5cc(Cl)ccc5OCc5ccccc5)n4)nc3c2)CC1.Cl,,CCO,CCOCC,Cl,,val
US20080021026A1,CC(=O)OC(C)=O.Cc1c(-c2ccnc(N)n2)sc2ccc(Cc3cccc(O)c3)cc12>>CC(=O)Oc1cccc(Cc2ccc3sc(-c4ccnc(N)n4)c(C)c3c2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120220575A1,CC(C)(C)[Si](C)(C)n1ccc2c(-c3ncc4c(n3)N3CCOCC3CN4)cccc21.COc1ccc(CC(=O)Cl)cc1>>COc1ccc(CC(=O)N2CC3COCCN3c3nc(-c4cccc5c4ccn5[Si](C)(C)C(C)(C)C)ncc32)cc1,,ClCCl,,CCN(CC)CC,,val
US05112859,CCCCCCCNCc1ccc(CC(C)(C)C)cc1.O=C(Cl)OC(Cl)(Cl)Cl.Oc1ccccc1-c1ccccc1>>CCCCCCCN(Cc1ccc(CC(C)(C)C)cc1)C(=O)Oc1ccccc1-c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US05258529,C=C(Cl)CCl.CC(=O)C=C(C)C>>C=C(Cl)CC(C)(O)C=C(C)C,[Zn],O,,Cc1ccccc1,,val
US06339160B1,CC(C)C[C@H](N)C(=O)OC(C)(C)C.O=C1CC[C@@H](C(=O)O)O1>>CC(C)C[C@H](NC(=O)[C@@H]1CCC(=O)O1)C(=O)OC(C)(C)C,,C1CCOC1,ClCCl,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20110152243A1,CCOC(=O)C(=O)c1cn(C(=O)OC(C)(C)C)c2ccsc12.NC(=O)Cc1nc(Cl)nc2ccccc12>>O=C1NC(=O)C(c2c[nH]c3ccsc23)=C1c1nc(Cl)nc2ccccc12,,O,,C1CCOC1,CC(C)(C)[O-].[K+],val
US20040043987A1,CS(=O)(=O)Cl.Nc1ccc2c(c1)S(=O)(=O)NC(C1CCCCC1)=N2>>CS(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)NC(C1CCCCC1)=N2,,C1CCOC1,,CCN(CC)CC,,val
US04122274,CCCCc1ccc(NC(=O)OCc2ccccc2)nc1>>CCCCc1ccc(N)nc1,[Pd],CCO,,[H][H],,val
US20050214479A1,Brc1ccc(Br)cc1.CCO[Si](OCC)(OCC)OCC>>CCO[Si](OCC)(OCC)c1ccc(Br)cc1,,CCOCC,CCOCC,[Mg],,val
US20120149778A1,Nc1ccc(NC(=O)OCc2ccccc2)cc1.O=C(Cl)CCCCBr>>O=C(CCCCBr)Nc1ccc(NC(=O)OCc2ccccc2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05174921,Clc1ccc(CBr)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Clc1ccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1.[Br-],,Cc1ccccc1,,,,val
US20040127574A1,CCOC(=O)C(Cc1ccc(C(C)(C)C)cc1)C(O)c1cccc(Cl)c1>>CC(C)(C)c1ccc(CC(C(=O)O)C(O)c2cccc(Cl)c2)cc1,,CCO,,[Na+].[OH-],,val
US20120088755A1,Cc1cc(O)cc([N+](=O)[O-])c1N.O=C(O)[C@H]1CCCO1>>Cc1cc(OC(=O)C2CCCO2)cc([N+](=O)[O-])c1N,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20080070935A1,Cc1cn(-c2ccc3c(N)ncc(C#N)c3c2)c2c1C(=O)CC(C)(C)C2.NO>>Cc1cn(-c2ccc3c(N)ncc(C(=N)NO)c3c2)c2c1C(=O)CC(C)(C)C2,,CCO,,CCN(CC)CC,,val
US20160152613A1,CC(C)(C)OC(=O)Cn1c2c(c(OS(=O)(=O)C(F)(F)F)cc1=O)C(=O)CC2.N#Cc1ccc(Cl)cc1B(O)O>>CC(C)(C)OC(=O)Cn1c2c(c(-c3cc(Cl)ccc3C#N)cc1=O)C(=O)CC2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20060199804A1,O=S(Cl)Cl.Oc1ncnc2cnccc12>>Clc1ncnc2cnccc12,,CN(C)C=O,,,,val
US20120010188A1,Nc1ccc(Cl)cn1.O=C(CBr)c1ccc(Br)cc1>>Br.Clc1ccc2nc(-c3ccc(Br)cc3)cn2c1,,CCO,,,,val
US20070066667A1,N#Cc1cc(S(=O)c2cccc(Br)c2)c([N+](=O)[O-])s1>>N#Cc1cc(Sc2cccc(Br)c2)c(N)s1,[Fe],CC(=O)O,,CCO,,val
US20090186912A1,CO/C=C/C(=O)Cl.Nc1ccc(Br)cc1>>CO/C=C/C(=O)Nc1ccc(Br)cc1,,ClCCl,,c1ccncc1,,val
US20040192930A1,COC(=O)C(=O)OC.COc1c(F)cc(C(C)=O)cc1F>>COC(=O)C(=O)CC(=O)c1cc(F)c(OC)c(F)c1,,CO,ClCCl,C[O-].[Na+],,val
US20030236412A1,CCOC(=O)C(C(C)=O)C(C)=O.Cc1ccc(NN)cc1>>CCOC(=O)c1c(C)nn(-c2ccc(C)cc2)c1C,,CCO,,c1ccncc1,,val
US20100273764A1,COc1ccc(CN(Cc2ccc(OC)cc2)c2cc(-c3cc([C@@H](C)N4CCNC[C@@H]4C)cnc3F)nc(C)n2)cc1.CS(=O)(=O)Cl>>COc1ccc(CN(Cc2ccc(OC)cc2)c2cc(-c3cc([C@@H](C)N4CCN(S(C)(=O)=O)C[C@@H]4C)cnc3F)nc(C)n2)cc1,,ClCCl,,CCN(CC)CC,[Na+].[OH-],val
US20150238597A1,C=CCO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>C=CCO[C@H]1O[C@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@H](O)[C@H](O)[C@H]1O,,c1ccncc1,,,,val
US20100093757A1,Cc1ccc(NC(=O)[C@H](COCCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)Oc2ncnc3c2cnn3-c2cccc(Cl)c2C)nc1>>Cc1ccc(NC(=O)[C@H](COCCO)Oc2ncnc3c2cnn3-c2cccc(Cl)c2C)nc1,,C1CCOC1,CCOC(C)=O,[Cl-].[NH4+],CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20090270435A1,CCOC(=O)c1cc(C(C)=O)ccc1Cl.COC(OC)N(C)C>>CCOC(=O)c1cc(C(=O)C=CN(C)C)ccc1Cl,,Cc1ccccc1,,CO,,val
US06376530B1,Cc1cc(OC(F)(F)F)ccc1C#N.O=C1CCC(=O)N1Br>>N#Cc1ccc(OC(F)(F)F)cc1CBr,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US04995899,COC(=O)C(C)CCC(C)=O.NCCN>>CC1CC2C(C)NCCN2C1=O,,CCCCCCC,,,,val
US20090286782A1,CC(C)[Si](C(C)C)(C(C)C)n1cc(I)c2cncnc21.CSc1ncc(C=O)cn1>>CSc1ncc(C(O)c2cn([Si](C(C)C)(C(C)C)C(C)C)c3ncncc23)cn1,,C1CCOC1,,CC(C)[Mg]Cl,[Cl-].[NH4+],val
US04409238,CC(C)C(CC=C(Cl)Cl)C(=O)O.O=S(Cl)Cl>>CC(C)C(CC=C(Cl)Cl)C(=O)Cl,,c1ccccc1,,,,val
US05665718,CN1Cc2c(-c3noc(CCl)n3)ncn2-c2ccc(F)cc2C1=O.NC1CC1>>CN1Cc2c(-c3noc(CNC4CC4)n3)ncn2-c2ccc(F)cc2C1=O,,CN(C)C=O,,,,val
US20160009726A1,COP(=O)(OC)C(=[N+]=[N-])C(C)=O.O=C[C@@H]1C[C@H]1c1ccccc1>>C#C[C@@H]1C[C@H]1c1ccccc1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20100152166A1,CC(C)(C)[Si](C)(C)OC1CCC(=O)CC1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)[Si](C)(C)OC1CC=C(OS(=O)(=O)C(F)(F)F)CC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20140256740A1,Cc1ccc(C(NC(=O)Cc2ccc(OCC(=O)c3c(C)noc3C)cc2)c2ccccc2)c(C)c1>>Cc1ccc(C(NC(=O)Cc2ccc(OCC(O)c3c(C)noc3C)cc2)c2ccccc2)c(C)c1,,CO,,O,[BH4-].[Na+],val
US20080269267A1,CCOC(=O)CC(=O)c1ccccc1.CCOC(OCC)OCC>>CCO/C=C(/C(=O)OCC)C(=O)c1ccccc1,,CC(=O)OC(C)=O,,,,val
US20100197683A1,CC(C)(C)OC(=O)CBr.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)[nH]c2ncnn12>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(CC(=O)OC(C)(C)C)c2ncnn12,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04758565,CC1(C)CN=C(Cc2ccccc2)NC1.O=[N+]([O-])c1cc(C(F)(F)F)ccc1F>>CC1(C)CN=C2C(c3ccccc3)=[N+]([O-])c3cc(C(F)(F)F)ccc3N2C1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05106863,CC(C)=CCC/C(C)=C/CCl.COc1ccc2[nH]c(S)nc2c1>>COc1ccc2ncn(C/C=C(\C)CCC=C(C)C)c2c1,,CN(C)C=O,ClCCl,[H-].[Na+],,val
US08470841B2,C[C@@H](COc1ccc(Oc2ccc(OCc3ccccc3)cc2)nc1)NC(=O)OCc1ccccc1>>C[C@H](N)COc1ccc(Oc2ccc(O)cc2)nc1,[Pd],CCO,,[H][H],,val
US20100234389A1,CC(C)(C)OC(=O)N1CCN(c2cc(Cl)ncn2)CC1.OB(O)c1cccc(F)c1F>>CC(C)(C)OC(=O)N1CCN(c2cc(-c3cccc(F)c3F)ncn2)CC1,,O,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20160122331A1,COC(=O)c1cccc([C@H]2CC(O)C[C@@H](c3ccccc3)O2)c1>>COC(=O)c1cccc([C@H]2CC(=O)C[C@@H](c3ccccc3)O2)c1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20080021011A1,CCC(=O)Cl.CNC1CCN(C(=O)Cn2nc(-c3ccncc3)cc2Cc2ccc(F)cc2)CC1>>CCC(=O)N(C)C1CCN(C(=O)Cn2nc(-c3ccncc3)cc2Cc2ccc(F)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US06015774,CS(=O)(=O)Cl.Cn1c(C(F)(F)F)cnc(-c2cc(N)c(Cl)cc2Cl)c1=O>>Cn1c(C(F)(F)F)cnc(-c2cc(NS(C)(=O)=O)c(Cl)cc2Cl)c1=O,,c1ccncc1,,O,,val
US04772600,O=C(O)Cn1c(-c2ccc(Br)cc2)nc2cccnc21.O=C(n1ccnc1)n1ccnc1>>CNC(=O)Cn1c(-c2ccc(Br)cc2)nc2cccnc21,,C1CCOC1,,,,val
US20130237535A1,CC1CC2(CCN1C(=O)OC(C)(C)C)CO2.NC1CC1>>CC1CC(O)(CNC2CC2)CCN1C(=O)OC(C)(C)C,,CCO,,,,val
US20060293340A1,Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nccc(-c2ccc(Cl)nc2)n1.NCCCN1CCOCC1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nccc(-c2ccc(NCCCN3CCOCC3)nc2)n1,,O,,,,val
US20090281103A1,Cc1cc(Cl)c(OCCOc2ccc(C(Cc3ccccn3)C(CNC(=O)OC(C)(C)C)C(=O)N(Cc3cccc(C)c3C)C3CC3)cc2)c(Cl)c1>>Cc1cc(Cl)c(OCCOc2ccc(C(Cc3ccccn3)C(CN)C(=O)N(Cc3cccc(C)c3C)C3CC3)cc2)c(Cl)c1,,ClCCl,,Cl,,val
US20090247746A1,CCOC(=O)c1sc(-c2cc3cccc(NS(=O)(=O)c4cccs4)c3[nH]2)nc1C>>Cc1nc(-c2cc3cccc(NS(=O)(=O)c4cccs4)c3[nH]2)sc1C(=O)O,,CO,,C1CCOC1,[Na+].[OH-],val
US20110237564A1,COC(=O)c1[nH]nnc1C(=O)Nc1ccn2cc(-c3ccccc3)nc2n1>>O=C(Nc1ccn2cc(-c3ccccc3)nc2n1)c1nn[nH]c1C(=O)O,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20110136780A1,COC(=O)c1cn(C(=O)OC(C)(C)C)c2nccc(C=O)c12.NC1(C(=O)O)CCCC1>>COC(=O)c1cn(C(=O)OC(C)(C)C)c2nccc(CNC3(C(=O)O)CCCC3)c12,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04845242,ClP(Cl)(Cl)(Cl)Cl.O=C(Cc1ccccc1C(=O)O)OCCBr.O=C(O)Cc1ccccc1C(=O)O.OCCBr.c1ccccc1>>O=C(Cc1ccccc1C(=O)O)OCCBr.O=c1oc(CCBr)c(Cl)c2ccccc12,O=S(=O)(O)O,c1ccccc1,,,,val
US05519034,BrCCCBr.N#CCc1ccc(OC(F)(F)F)cc1>>N#CC1(c2ccc(OC(F)(F)F)cc2)CCC1,,C1CCOC1,CN(C)C=O,O,[H-].[Na+],val
US04214094,CCOC(=O)C(C)(C)Br.Oc1ccc(C=Nc2ccccc2)cc1>>CCOC(=O)C(C)(C)Oc1ccc(C=Nc2ccccc2)cc1,,CCO,,[Na],,val
US20130303492A1,CSC(Nc1cccc(C(C)(C)C)c1)=C(C#N)C(N)=O.NN>>CC(C)(C)c1ccc(Nc2n[nH]c(N)c2C(N)=O)cc1,,CCO,,O,,val
US20130210795A1,CNC(=O)c1cc(C=O)ccn1.C[Mg]Br>>CNC(=O)c1cc(C(C)O)ccn1,,CCOC(C)=O,,C1CCOC1,O=C([O-])O.[Na+],val
US20070135493A1,N[C@@H]1C[C@H]1c1ccccc1.O=C=NS(=O)(=O)Cl.OCCBr>>O=C1OCCN1S(=O)(=O)NC1CC1c1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US04304913,COc1cc2c(cc1OC)C1CC(N)CCN1CC2.O=C(Cl)c1ccccc1>>COc1cc2c(cc1OC)C1CC(NC(=O)c3ccccc3)CCN1CC2.Cl,,c1ccccc1,,[Na+].[OH-],,val
US20050014804A1,CC(C)CC(C[N+](=O)[O-])c1nnnn1Cc1ccccc1>>CC(C)CC(CN)c1nnn[nH]1,[Pd],CO,,Cl,,val
US20140364414A1,CC(C)(C)OC(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(C=O)cn23)cc1.COP(=O)(OC)C(=[N+]=[N-])C(C)=O>>C#Cc1cn2c(-c3ccc(C(=O)OC(C)(C)C)cc3)cnc(N3CCOCC3)c2n1,,C1CCOC1,CO,O=C([O-])[O-].[K+].[K+],,val
US05081301,BrCC/C=C/c1ccccc1.O=C1c2ccccc2C(=O)N1O>>O=C1c2ccccc2C(=O)N1OCC/C=C/c1ccccc1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20140303127A1,CC(C)(C)[Si](C)(C)O[C@@H](CN)c1ccc(O)c2[nH]c(=O)ccc12.CN(CCCn1ccc2cc(C=O)ccc21)[C@@H]1CC[C@@H](OC(=O)C(O)(c2cccs2)c2cccs2)CC1>>CN(CCCn1ccc2cc(CNC[C@H](O[Si](C)(C)C(C)(C)C)c3ccc(O)c4[nH]c(=O)ccc34)ccc21)[C@@H]1CC[C@@H](OC(=O)C(O)(c2cccs2)c2cccs2)CC1,,C1CCOC1,CO,CC(=O)O,O=C([O-])O.[Na+],val
US20120202861A1,COc1ccc(-c2c(Br)n(C#N)c3ccccc23)cc1.Cc1nsc(C)c1B(O)O>>COc1ccc(-c2c(-c3c(C)nsc3C)n(C#N)c3ccccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])O.[Na+],,val
US20040132726A1,CCOC(=O)Cl.CNC1CCCCN1Cc1noc(-c2cc(C)ccc2F)n1>>CCOC(=O)NCC1CCCCN1Cc1noc(-c2cc(C)ccc2F)n1,,CCCCCCC,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20100105682A1,CCOC(=O)C1CC1CN1CCN(C(c2ccccc2)c2ccccc2)CC1>>O=C(O)C1CC1CN1CCN(C(c2ccccc2)c2ccccc2)CC1,,CO,,C1CCOC1,O,val
US20070060754A1,CC(C)(C)OC(=O)NN1CCN(C(=O)CBr)CC1.CCCn1c(COCC)nc2cnc3ccc(O)cc3c21>>CCCn1c(COCC)nc2cnc3ccc(OCC(=O)N4CCN(C(=O)OC(C)(C)C)CC4)cc3c21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160222060A1,O=C(N[C@H](CO)Cc1ccccc1)OCc1ccccc1>>O=C[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1,,ClCCl,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20090124612A1,COc1ccc2c(OCc3nnc4ccc(C5=CCN(C(=O)OC(C)(C)C)CC5)cn34)ccnc2c1>>COc1ccc2c(OCc3nnc4ccc(C5=CCNCC5)cn34)ccnc2c1,,CO,,CCN(CC)CC,Cl,val
US20130184304A1,CC(=CBr)c1ccc(F)cc1.Cc1ccc2[nH]c3c(c2c1)CN1CCCC1C3>>C/C(=C\n1c2c(c3cc(C)ccc31)CN1CCCC1C2)c1ccc(F)cc1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20080119469A1,N#Cc1nc(Cl)c2c(n1)N(c1ccc(Cl)cc1)CC2.NC(=O)[C@@H]1CCCN1>>N#Cc1nc2c(c(N3CCC[C@H]3C(N)=O)n1)CCN2c1ccc(Cl)cc1,,CS(C)=O,,CCN(C(C)C)C(C)C,,val
US20070213331A1,CCCN(C)C(=O)c1cc(I)cc(C(=O)O)c1.O=C(Cl)OCc1ccccc1>>CCCN(C)C(=O)c1cc(I)cc(C(=O)OCc2ccccc2)c1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20090209607A1,CCc1cnn(C)c1-c1cc(C(=O)O)sc1CC.N[C@@H](Cc1ccccc1C(F)(F)F)CN1C(=O)c2ccccc2C1=O>>CCc1cnn(C)c1-c1cc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)sc1CC,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US20070219230A1,O=[N+]([O-])c1cccnc1CBr.Oc1ccc(F)cc1>>O=[N+]([O-])c1cccnc1COc1ccc(F)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20140051679A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1cc(Br)ccc1N1CCN(C)CC1>>COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1N1CCN(C)CC1,,CS(C)=O,,CC(=O)[O-].[K+],,val
US04517202,COC1=CCC2C(CCC2OC(C)=O)C1>>CC(=O)OC1CCC2CC(=O)CCC21,,CO,,Cl,,val
US06211215B1,OCCc1coc(-c2cccs2)n1.Oc1ccc(CCCn2ccnc2)cc1>>c1csc(-c2nc(CCOc3ccc(CCCn4ccnc4)cc3)co2)c1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05550134,CN1C(=O)CC[C@]2(C)c3ccc(S)cc3CC[C@@H]12.COc1ccc2nc(Cl)sc2c1>>COc1ccc2nc(Sc3ccc4c(c3)CC[C@H]3N(C)C(=O)CC[C@]43C)sc2c1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20080194598A1,N#Cc1ccccc1F.[Cl-].[NH4+]>>Cl.N=C(N)c1ccccc1F,,Cc1ccccc1,,C[Al](C)C,,val
US20070244178A1,BrCc1ccccc1.Brc1cccc2[nH]ncc12>>Brc1cccc2nn(Cc3ccccc3)cc12,,CCOC(C)=O,O,CN(C)C=O,,val
US20030018067A1,CCCCC(=O)c1c(-c2ccc3cc(OC(Cc4ccccc4)C(=O)OCC)ccc3c2)oc2ccccc12>>CCCCC(=O)c1c(-c2ccc3cc(OC(Cc4ccccc4)C(=O)O)ccc3c2)oc2ccccc12,,C1CCOC1,O,[K+].[OH-],,val
US05811459,CO.CSc1ccc(OCc2ccccc2)c(CCCc2ccc(C(=O)NCCO)cc2)c1>>CS(=O)c1ccc(OCc2ccccc2)c(CCCc2ccc(C(=O)NCCO)cc2)c1,,CO,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US06420418B1,C=C1COC(C)(C(=O)OC(C)(C)C)C1>>C=C1COC(C)(C(=O)O)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050209291A1,O=C(NC(=S)Nc1ccc2nc(NCCc3ccc(Br)cc3)sc2c1)c1ccccc1>>NC(=S)Nc1ccc2nc(NCCc3ccc(Br)cc3)sc2c1,,C1CCOC1,,[Na+].[OH-],,val
US20100168156A1,COc1cccc(SC(=S)N(C)C)c1O>>COc1cccc(S)c1O,,C1CCOC1,,[Na+].[OH-],[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20100210672A1,Cc1nscc1-c1cn(CCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)c(=O)[nH]c1=O.Cl>>Cc1nscc1-c1cn(CCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)c(=O)[nH]c1=O.Cl,,CCOCC,,,,val
US20100063285A1,CCOC(CBr)OCC.C[C@@H](n1cc(N)cn1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F>>CCOC(CNc1cnn([C@H](C)[C@](O)(Cn2cncn2)c2ccc(F)cc2F)c1)OCC,,CN(C)C=O,,CCN(CC)CC,,val
US03966956,CC(=O)CCC(=O)OCC(=O)OCc1ccccc1.COc1ccc(NN)cc1>>COc1ccc(NN=C(COC(=O)CCC(C)=O)OCc2ccccc2)cc1,,CC(=O)O,,O,,val
US20110301161A1,CC(C)(C)n1c(-c2ccccc2Br)nc2cc(-c3cnc(N)nc3)ccc21.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>Cn1cc(-c2ccccc2-c2nc3cc(-c4cnc(N)nc4)ccc3n2C(C)(C)C)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20080293704A1,CC(=O)Cl.Nc1cc(-n2ccccc2=O)ccc1-n1cc(CNC(=O)c2ccc(Cl)s2)nn1>>CC(=O)Nc1cc(-n2ccccc2=O)ccc1-n1cc(CNC(=O)c2ccc(Cl)s2)nn1,,CS(C)=O,,c1ccncc1,,val
US20150111877A1,COC(=O)c1cnc2c(c1)N(S(=O)(=O)c1cccc(C)c1)CC=C2>>COC(=O)c1cnc2c(c1)N(S(=O)(=O)c1cccc(C)c1)CCC2,,CO,,,,val
US20040010009A1,CC(C)(C)OC(=O)N1CCC(O)CC1.O=[N+]([O-])c1ccc(O)c(Cl)c1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])cc2Cl)CC1,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140323478A1,CCn1c(=O)c(Br)cc2cnc(S(C)=O)nc21.CN1CCC(CCN)CC1>>CCn1c(=O)c(Br)cc2cnc(NCCC3CCN(C)CC3)nc21,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20090036492A1,CON.COc1cc(O)c2c(c1C(=O)NCc1c(C)ccc3ccccc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C>>CO/N=C(\C)C1=C(O)C=C2Oc3c(C(=O)NCc4c(C)ccc5ccccc45)c(OC)cc(O)c3[C@]2(C)C1=O,,C1CCOC1,CO,Cl,O=C([O-])O.[Na+],val
US20140256718A1,CC(C)(C)[Si](C)(C)OCc1c(F)cc(B(O)O)cc1F>>OCc1c(F)cc(B(O)O)cc1F,,CC(=O)O,,,,val
US20080207654A1,CCCCc1nc(C)n(-c2cc(Cl)cc(Cl)c2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCCc1nc(C)n(-c2cc(Cl)cc(Cl)c2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20140194430A1,CNCC(C)O.Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1>>CC(O)CN(C)c1ccc2ncc(-c3cc4ccccc4o3)n2n1,,CN(C)C=O,,[H-].[Na+],,val
US20150119362A1,COC(=O)Cc1ccc(N)cn1>>Nc1ccc(CCO)nc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060014739A1,COC(=O)C1=CCC2CCC1N2c1ccc(C#N)c2ccccc12>>COC(=O)C1CCC2CCC1N2c1ccc(C#N)c2ccccc12,[Pd],CO,,,,val
US05977139,C=CC(=O)OCC.CC(C)(C)OC(=O)N1CCNCC1>>CCOC(=O)CCN1CCN(C(=O)OC(C)(C)C)CC1,,CCO,,CCOCC,,val
US20030225283A1,COC(=O)CCSCCC(=O)OC>>COC(=O)C1=C(O)CCSC1,,COCCOC,,[H-].[Na+],,val
US20060211693A1,CCOC(=O)c1ccc(SC)cc1OCC.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)c1ccc(S(C)=O)cc1OCC,,ClCCl,,CCOC(C)=O,,val
US20050112770A1,CCOC(=O)CCC[N+](C)(C)CCCCCCBr.Cc1ccnc2ccccc12.[Br-]>>CCOC(=O)CCC[N+](C)(C)CCCCCC[n+]1ccc(C)c2ccccc21.[Br-].[Br-],,CCOC(C)=O,,,,val
US20130210824A1,N=C(N)c1nn(Cc2ccccc2F)c2ncncc12.NN>>N=C(NN)c1nn(Cc2ccccc2F)c2ncncc12,,CCO,,CCN(CC)CC,O,val
US20120108568A1,CCOC(=O)C1CCN(C(=O)c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)CC1>>O=C(O)C1CCN(C(=O)c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)CC1,,C1CCOC1,CO,[Li+].[OH-],,val
US04937268,OCCCl.SCCc1ccccc1>>OCCSCCc1ccccc1,,CO,,Cl,[K+].[OH-],val
US20010025047A1,CCOC(=O)c1cnc2c(c(C)nn2C)c1Cl.COc1ccc(S(=O)(=O)NCc2ccccc2)cc1>>CCOC(=O)c1cnc2c(c(C)nn2C)c1N(Cc1ccccc1)S(=O)(=O)c1ccc(OC)cc1,,CN1CCCC1=O,,,,val
US20140349993A1,CCOC(=O)c1nc[nH]c1N.O=C(C=CON1C(=O)CCC1=O)ON1C(=O)CCC1=O>>CCOC(=O)c1ncn2ccc(=O)[nH]c12,,CC#N,,CCN(CC)CC,,val
US20060205774A1,O=C(C1CCOCC1)N1CCC(c2ccc(O)cc2)CC1.OCCCCl>>O=C(C1CCOCC1)N1CCC(c2ccc(OCCCO)cc2)CC1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06956050B2,CCc1nc(-c2ccccc2)cn1-c1ccc(CCN)cc1.O=C(Cl)Oc1ccccc1>>CCc1nc(-c2ccccc2)cn1-c1ccc(CCNC(=O)Oc2ccccc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20130196974A1,Cc1ccc2nc(Cl)nc(NCCNC(=O)OC(C)(C)C)c2c1.c1ccc2c(c1)CNCCS2>>Cc1ccc2nc(N3CCSc4ccccc4C3)nc(NCCNC(=O)OC(C)(C)C)c2c1,,CCCCO,,CCN(CC)CC,,val
US07495007B2,C=C(C)C1N(C(=O)OC(C)(C)C)C(=O)CC(c2cccc(Cl)c2)C12C(=O)N(C(=O)OC(C)(C)C)c1cc(Cl)ccc12.C[Si](C)(C)OC(=O)C(F)(F)S(=O)(=O)F>>C[C@]1(C2NC(=O)CC(c3cccc(Cl)c3)C23C(=O)Nc2cc(Cl)ccc23)CC1(F)F,,Cc1ccccc1,,[F-].[K+],,val
US20130096144A1,O=C1NC(=O)c2ccccc21.O=C1c2cnc(Cl)cc2CN1[C@H](CO)Cc1cc(F)cc(F)c1>>O=C1c2ccccc2C(=O)N1C[C@H](Cc1cc(F)cc(F)c1)N1Cc2cc(Cl)ncc2C1=O,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04383945,C=CC[C@@H]1[C@@H](C(C)O)C(=O)N1C(C(=O)OC)=C(C)C.O=CO>>C=CC[C@@H]1[C@@H]([C@@H](C)OC=O)C(=O)N1C(C(=O)OC)=C(C)C,,C1CCOC1,CCOC(C)=O,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05399655,C1=COCCC1.Nc1ccc(S(=O)(=O)c2ccc(N)cc2)cc1>>C1=COCCC1.Nc1ccc(S(=O)(=O)c2ccc(N)cc2)cc1,,C1CCOC1,,Cl,,val
US20140249196A1,COC(=O)[C@H](C)O.Cc1nc2cc(C(=O)N[C@@H](C)c3cccc(C(C)C)c3)ccc2n1Cc1cccc(O)c1>>COC(=O)[C@H](C)Oc1cccc(Cn2c(C)nc3cc(C(=O)N[C@@H](C)c4cccc(C(C)C)c4)ccc32)c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04031221,Cc1ccc(OC2CCCN(Cc3ccccc3)C2)cc1>>Cc1ccc(OC2CCCNC2)cc1,[Pd],CCO,,,,val
US20130190284A1,Cc1ccc2ccc(Br)cc2n1.O=[Se]=O>>O=Cc1ccc2ccc(Br)cc2n1,,C1COCCO1,,,,val
US20010047094A1,CC(=O)O.Cc1ccnc(N)c1>>CC(=O)Nc1cc(C)ccn1,,CC(=O)O,,CC(=O)OC(C)=O,,val
US04592866,CN1CC(CCCl)Oc2ncccc2C1=O.c1cn[nH]c1>>CN1CC(CCn2cccn2)Oc2ncccc2C1=O,,CN(C)C=O,,[H-].[Na+],,val
US20070208054A1,NCc1cccc(N)c1.O=C(Cl)OCc1ccccc1>>Nc1cccc(CNC(=O)OCc2ccccc2)c1,,C1CCOC1,,,,val
US04188390,COc1cccc2c1OC(C(N)=O)CO2.O>>COc1cccc2c1OC(C(=O)O)CO2,,Cl,,,,val
US05733913,CN1CCN(CCCNc2ncc3cc(-c4c(Cl)cccc4Cl)c(N)nc3n2)CC1.COc1ccccc1N=C=O>>COc1ccccc1NC(=O)Nc1nc2nc(NCCCN3CCN(C)CC3)ncc2cc1-c1c(Cl)cccc1Cl,,CC#N,CO,,,val
US04839369,CCOC(=O)CBr.c1cc(OCc2ccc3ccccc3n2)cc(-c2nnn[nH]2)c1>>CCOC(=O)Cn1nnc(-c2cccc(OCc3ccc4ccccc4n3)c2)n1,,CCO,,[Na],,val
US20020086890A1,CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCNCC2)cc1.COc1ccc(C(=O)Cl)cc1>>CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCN(C(=O)c3ccc(OC)cc3)CC2)cc1,,ClC(Cl)Cl,,CCN(CC)CC,CN(C)c1ccccn1,val
US20130317029A1,CSc1nc(Cl)c(C#N)c(Nc2ccc(I)cc2)n1.OCc1ccccc1>>CSc1nc(Nc2ccc(I)cc2)c(C#N)c(OCc2ccccc2)n1,,CN1CCCC1=O,,[H-].[Na+],,val
US07812045B2,Fc1ccc(C2(Cn3cncn3)CO2)c(F)c1.c1ccc2[nH]ncc2c1>>OC(CN1NCc2ccccc21)(Cn1cncn1)c1ccc(F)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US20060160786A1,OC1CCN(Cc2ccccc2)CC1.Oc1ccccc1Cl>>Clc1ccccc1OC1CCN(Cc2ccccc2)CC1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050267093A1,CCN(CC)CCO.O=[N+]([O-])c1ccc(F)c(Br)c1>>CCN(CC)CCOc1ccc([N+](=O)[O-])cc1Br,,CO,ClCCl,,,val
US04425473,CCC(CO)(CO)CO.CCOC(OCC)(OCC)C(C)Br>>CCC12COC(C(C)Br)(OC1)OC2,Cc1ccc(S(=O)(=O)O)cc1,CCO,,,,val
US20110263602A1,CN(C(=O)OC(C)(C)C)C1CCNCC1.Cc1c(Cl)nnc(Cl)c1C>>Cc1c(Cl)nnc(N2CCC(N(C)C(=O)OC(C)(C)C)CC2)c1C,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090286882A1,C=CCOC(=O)C(Cc1ccc(C(=O)OC(C)(C)C)cc1)C(=O)OCC=C.CCOC(=O)CC1(CCBr)CC1>>C=CCOC(=O)C(CCC1(CC(=O)OCC)CC1)(Cc1ccc(C(=O)OC(C)(C)C)cc1)C(=O)OCC=C,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050165006A1,Cc1cc2cc([N+](=O)[O-])ccc2nc1Cl.O=CN1CCNCC1>>Cc1cc2cc([N+](=O)[O-])ccc2nc1N1CCN(C=O)CC1,,CN(C)C=O,,O,,val
US05461175,CC(C)NCC(O)COc1ccc(CC(N)=O)cc1>>CC(C)NC[C@H](O)COc1ccc(CC(N)=O)cc1,,CC#N,CC(=O)O,,,val
US20150119385A1,COC(OC)c1nc2c(cc1Br)CCCN2C(=O)Oc1ccccc1.COCCNc1cc(N)ncc1C#N>>COCCNc1cc(NC(=O)N2CCCc3cc(Br)c(C(OC)OC)nc32)ncc1C#N,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20060069149A1,CN(C)CCCl.COc1ccc2c(c1)Oc1ccccc1-c1cc(C(=O)O)sc1-2>>COc1ccc2c(c1)Oc1ccccc1-c1cc(C(=O)OCCN(C)C)sc1-2,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060241142A1,CC(C)(C)OC(=O)N(CCCl)CCCl.N#CCc1ccc(Cl)c(Cl)c1>>CC(C)(C)OC(=O)N1CCC(C#N)(c2ccc(Cl)c(Cl)c2)CC1,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06511997B1,Nc1n[nH]c(-c2ccc(F)cc2)c1-c1ccncc1.O=C(O)CC1CCCCC1>>O=C(CC1CCCCC1)Nc1n[nH]c(-c2ccc(F)cc2)c1-c1ccncc1,,C1CCOC1,O,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20010020095A1,OCCC1Cc2ccccc2C1.[I-]>>ICCC1Cc2ccccc2C1,,Cc1ccccc1,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05925792,CCCCCCCC(=O)Cl.COC(=O)CC(C)=O>>CCCCCCCC(=O)CC(=O)OC,,C1CCOC1,,[H-].[Na+],,val
US20090298816A1,COC(=O)c1c(N)ccc2cn[nH]c12.O=C1CCC(=O)N1Br>>COC(=O)c1c(N)c(Br)cc2cn[nH]c12,,CN(C)C=O,,,,val
US20080306270A1,COC(=O)c1ccccc1CC[C@H](O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1.CS(=O)(=O)Cl>>COC(=O)c1ccccc1CC[C@H](OS(C)(=O)=O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06359134B1,Cl.O=C(c1ccc(Cn2ccnc2)cc1)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1>>Cl.O=C(c1ccc(Cn2ccnc2)cc1)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1,,CCOC(C)=O,,,,val
US20150065482A1,COC(=O)c1n[nH]c2ncccc12.C[Si](C)(C)CCOCCl>>COC(=O)c1nn(COCC[Si](C)(C)C)c2ncccc12,,CN(C)C=O,,[H-].[Na+],,val
US20080004327A1,COC(=O)c1cc([N+](=O)[O-])c(C=CN(C)C)s1>>COC(=O)c1cc2[nH]ccc2s1,[Pd],CO,,O=C[O-].[NH4+],,val
US20150353548A1,CCI.O=S1(=O)NCc2cc(Br)ccc21>>CCN1Cc2cc(Br)ccc2S1(=O)=O,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130079320A1,CC(C)(C)O.NCc1ccc([N+](=O)[O-])cc1F.O=C=NS(=O)(=O)Cl>>CC(C)(C)OC(=O)NS(=O)(=O)NCc1ccc([N+](=O)[O-])cc1F,,ClCCl,,CCN(CC)CC,,val
US20140309208A1,CCOc1c(Nc2cccc(C(=O)O)c2O)c(=O)c1=O.Cc1ccc(C(N)C2(C)COC2)o1>>Cc1ccc(C(Nc2c(Nc3cccc(C(=O)O)c3O)c(=O)c2=O)C2(C)COC2)o1,,CO,,,,val
US20130059845A1,CCOC(=O)c1c(-c2cc(Cl)ccc2Cl)nc2cnccn12>>O=C(O)c1c(-c2cc(Cl)ccc2Cl)nc2cnccn12,,CO,,[Li+].[OH-],,val
US20040242659A1,CN.O=C(n1ccnc1)n1ccnc1.OCCc1nccn1CCCCc1ccc(OCc2coc(/C=C/c3ccc(C(F)(F)F)cc3)n2)cc1>>CNC(=O)OCCc1nccn1CCCCc1ccc(OCc2coc(/C=C/c3ccc(C(F)(F)F)cc3)n2)cc1,,C1CCOC1,,O,,val
US20030166639A1,Cc1nccc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)ccc3NC(=O)OC(C)(C)C)c2)c1C>>Cc1nccc(-c2cccc(C3=Nc4ccc(C(F)(F)F)cc4NC(=O)C3)c2)c1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050038248A1,COc1cc(N)cc(OC)c1OC.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>COc1cc(-c2cccc(S(N)(=O)=O)c2[N+](=O)[O-])cc(OC)c1OC,,ClCCl,,CCN(CC)CC,,val
US20150038515A1,CCOC(=O)CBr.O=S(=O)(Nc1cc(C(F)(F)F)ccc1Cl)c1ccccc1>>CCOC(=O)CN(c1cc(C(F)(F)F)ccc1Cl)S(=O)(=O)c1ccccc1,,C1CCOC1,,[H-].[Na+],,val
US20140057937A1,CC(C)(C(=O)O)c1ccc(Cl)c(C(F)(F)F)c1.Fc1ccc(-n2ncc3c2CCCN3)cc1>>CC(C)(C(=O)N1CCCc2c1cnn2-c1ccc(F)cc1)c1ccc(Cl)c(C(F)(F)F)c1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04886822,COc1ccc(-c2ccccn2)c([N+](=O)[O-])c1>>COc1ccc(-c2ccccn2)c(N)c1,,CCO,,Cl,[Na+].[OH-],val
US20110212918A1,CCOC(=O)Cl.Nc1cc(OCc2ccccc2)ccc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2>>CCOC(=O)Nc1cc(OCc2ccccc2)ccc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2,,ClCCl,,,,val
US20150225452A1,C=CC=C.COC(=O)c1ccc(COc2ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)/C=C/C(=O)N[C@@H]3CCCc4ccccc43)cc2)cc1>>COC(=O)c1ccc(COc2ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)[C@H]3CC=CC[C@@H]3C(=O)N[C@@H]3CCCc4ccccc43)cc2)cc1,,Cc1ccccc1,,,,val
US20040106653A1,COc1cccc(S(=O)(=O)c2ccc(CCCNC(=O)C(F)(F)F)cc2)c1>>COc1cccc(S(=O)(=O)c2ccc(CCCN)cc2)c1,,C1COCCO1,,[Na+].[OH-],,val
US06130241,CCCCCCCCI.O=C1NC(=O)C2CC12>>CCCCCCCCN1C(=O)C2CC2C1=O,,CN(C)C=O,O,[H-].[Na+],,val
US20140088101A1,CC(C)(C)OC(=O)C(C)(C)CNC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O>>CC(C)(CNC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US06172076B2,Cc1cccc(N2CNC(=O)C23CCNCC3)c1.N#Cc1ccc(Cn2cncc2CCl)cc1>>Cc1cccc(N2CNC(=O)C23CCN(Cc2cncn2Cc2ccc(C#N)cc2)CC3)c1,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20110021352A1,CCOC(=O)CC(=O)C(F)(F)F.Nc1ncccc1C=O>>CCOC(=O)c1cc2cccnc2nc1C(F)(F)F,,CCO,,C1CCNCC1,,val
US04182877,CCOC(=O)c1c(Cl)cc(C)cc1N(C)C.O=[N+]([O-])O>>CCOC(=O)c1c(N(C)C)cc(C)c([N+](=O)[O-])c1Cl,,O=S(=O)(O)O,,O,,val
US20040029814A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cccc(C[C@H](N)C(=O)O)c1>>Cc1cccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)c1,,CCN(CC)CC,CO,,,val
US20160159808A1,CCOC(=O)c1cnn2cc(C)c(Cl)nc12.Cc1c[nH]nn1>>CCOC(=O)c1cnn2cc(C)c(-n3cc(C)nn3)nc12,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05324832,ClC(Cl)Cl.O=C1Nc2cccnc2N(C(=O)CN2CCN(CCO)CC2)c2ccccc21.O=S(Cl)Cl>>Cl.Cl.O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCl)CC2)c2ccccc21,,ClC(Cl)Cl,,,,val
US20110084599A1,Clc1ccc(Br)cc1Cl.OB(O)c1ccccc1>>Clc1ccc(-c2ccccc2)cc1Cl,,O,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])[O-].[K+].[K+],val
US04997836,COc1cc(CN2CCNC(CCCO)C2)cc(OC)c1OC.COc1cc2c(cc1OC)CCCC(C(=O)Cl)=C2>>COc1cc2c(cc1OC)CCCC(C(=O)N1CCN(Cc3cc(OC)c(OC)c(OC)c3)CC1CCCO)=C2,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20140275058A1,C=CCCl.O/N=C(\Cl)c1cc(Br)ccc1F>>Fc1ccc(Br)cc1C1=NOC(CCl)C1,,CCOC(C)=O,CCOCC,Cl,O,val
US20100136136A1,CC=O.Cc1cc(OC2CCNCC2)ccc1NC(=O)c1nc[nH]c1C(=O)Nc1nc2ccccc2[nH]1>>CCN1CCC(Oc2ccc(NC(=O)c3nc[nH]c3C(=O)Nc3nc4ccccc4[nH]3)c(C)c2)CC1,,CN(C)C=O,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20050256158A1,COc1ccc(C(=O)N2c3ccccc3[C@H](N(C(C)=O)c3ccc(Cl)cc3)C[C@@H]2C)cc1F>>CC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2ccc(O)c(F)c2)c2ccccc21,,ClCCl,,BrB(Br)Br,,val
US20160128989A1,CC1(C)OB(c2ccc(N)c(C#N)c2)OC1(C)C.COc1cccc(-c2nn(C3CCCCO3)c3nc(Cl)cc(C(F)F)c23)c1>>COc1cccc(-c2nn(C3CCCCO3)c3nc(-c4ccc(N)c(C#N)c4)cc(C(F)F)c23)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US06265575B1,COc1ccc(CC(=S)N(C)C)c(O)c1F>>COc1cc2sc(N(C)C)cc2cc1F,,ClCCl,,CS(=O)(=O)O,,val
US20140162876A1,CC(C)[Mg]Cl.O=C(Cn1cncn1)c1ccc(Oc2ccc(Cl)cc2)cc1Cl>>CC(C)C(O)(Cn1cncn1)c1ccc(Oc2ccc(Cl)cc2)cc1Cl,,C1CCOC1,ClCCl,,,val
US03961051,CC(=O)CCC=C(C)CCC1(C)OC1(C)C.CCOC(=O)C(CC)(CC)P(=O)(O)O>>CCOC(=O)C=C(C)CCC=C(C)CCC1(C)OC1(C)C,,CCO,,[Na],,val
US20020072518A1,CCOC(=O)CC1CCc2cc(OCCc3cccc(NC(=O)OC(C)(C)C)n3)ccc2C1>>CC(C)(C)OC(=O)Nc1cccc(CCOc2ccc3c(c2)CCC(CC(=O)O)C3)n1,,CO,O,[Na+].[OH-],,val
US20060084680A1,CCOC(=O)Cc1nc(-c2ccc(OC)cc2)ccc1C>>COc1ccc(-c2ccc(C)c(CCO)n2)cc1,,C1CCOC1,,[BH4-].[Li+],,val
US20160039847A1,II.OCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1>>Clc1ccc(N2CCN(CCCI)CC2)cc1Cl,,ClCCl,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06632826B1,CCOC(=O)CC(CC1OC(C)(C)N(C(=O)OC(C)(C)C)C1Cc1ccccc1)OS(C)(=O)=O>>CCOC(=O)C=CCC1OC(C)(C)N(C(=O)OC(C)(C)C)C1Cc1ccccc1,,ClCCl,,,,val
US20150080549A1,CC(C)C[C@@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](COC(C)(C)C)C(=O)NCC(N)=O)C(C)C)N(C)C(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](C)NC(=O)CNC(=O)OC(C)(C)C.SCc1ccccc1>>CC(C)C[C@@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)SCc1ccccc1)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](COC(C)(C)C)C(=O)NCC(N)=O)C(C)C)N(C)C(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](C)NC(=O)CNC(=O)OC(C)(C)C,CN(C)c1ccncc1,CN(C)C=O,ClCCl,CC(C)N=C=NC(C)C,,val
US04598090,COC(=O)c1ccc2oc3c(c(=O)c2c1)CCC3.Cc1ccccc1C=O>>COC(=O)c1ccc2oc3c(c(=O)c2c1)CCC3=Cc1ccccc1C,,CO,,C[O-].[Na+],,val
US05686482,COc1ccc(C(=O)O)c(OC)c1.O=[N+]([O-])O>>COc1cc(OC)c([N+](=O)[O-])cc1C(=O)O,,O=S(=O)(O)O,,,,val
US20150045324A1,CN1CCN(c2ccc(Nc3nc(Oc4cccc([N+](=O)[O-])c4)c4sccc4n3)cc2)CC1>>CN1CCN(c2ccc(Nc3nc(Oc4cccc(N)c4)c4sccc4n3)cc2)CC1,[Fe],CCO,,Cl,,val
US20040242580A1,CCCCn1nc(C)ncc1=O.Cc1ccc([Mg]Br)cc1>>CCCCN1N=C(C)NC(c2ccc(C)cc2)C1=O,,CCOCC,,CCOC(C)=O,[Cl-].[NH4+],val
US20120059014A1,CC1CCC(=O)N([C@H]2CN(c3ncc(OCC[C@@H](C)C4CCN(c5nc(C(C)C)no5)CC4)cn3)C[C@@H]2NC(=O)OC(C)(C)C)C1>>CC1CCC(=O)N([C@H]2CN(c3ncc(OCC[C@@H](C)C4CCN(c5nc(C(C)C)no5)CC4)cn3)C[C@@H]2N)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130217715A1,CC(C)(C)OC(=O)Nc1cccc(-c2ccn[nH]2)c1F.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)Nc1cccc(-c2[nH]ncc2Br)c1F,,ClCCl,,,,val
US20090240052A1,COC(=O)c1ccc(C#Cc2ccccc2)cc1NC(=O)c1ccccc1>>O=C(Nc1cc(C#Cc2ccccc2)ccc1C(=O)O)c1ccccc1,,C1CCOC1,,CO,[Na+].[OH-],val
US06225329B1,COC(=O)c1cc(Br)ccc1N.OB(O)c1ccccc1>>COC(=O)c1cc(-c2ccccc2)ccc1N,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US04243807,Cl.O=S(Cl)Cl.OCc1ccncc1>>Cl.ClCc1ccncc1,,c1ccccc1,,,,val
US06034239,C#CCBr.CCC(=O)NCCC1CCc2cc(F)c(O)cc21>>C#CCOc1cc2c(cc1F)CCC2CCNC(=O)CC,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06492416B1,CSc1ccc(C2=C(c3cc(F)cc(F)c3)C(=O)C(C)(C)O2)cc1C.O=C(OO)c1cccc(Cl)c1>>Cc1cc(C2=C(c3cc(F)cc(F)c3)C(=O)C(C)(C)O2)ccc1S(C)=O,,ClCCl,,O=C([O-])O.[Na+],,val
US20050020659A1,CCOC(=O)C(Cc1ccccc1[N+](=O)[O-])(NC(C)=O)C(=O)OCC>>CCOC(=O)C(Cc1ccccc1N)(NC(C)=O)C(=O)OCC,[Pd],CCO,,[H][H],,val
US20070299258A1,CCCN1CCCCC1CCO.O=S(Cl)Cl>>CCCN1CCCCC1CCCl,,ClCCl,,,,val
US20140243239A1,CC(C)(C)OC(=O)NCCCN1CCC2(CC1)CCN(C(=O)OCc1ccccc1)C2>>CC(C)(C)OC(=O)NCCCN1CCC2(CCNC2)CC1,,CO,,,,val
US20160002221A1,CC1(C)OCC(=O)c2cc(OS(=O)(=O)C(F)(F)F)ccc21>>CC1(C)OCC(O)c2cc(OS(=O)(=O)C(F)(F)F)ccc21,,CO,,[BH4-].[Na+],,val
US20120129863A1,Cc1cccc2c1c(CC(=O)O)cn2C.O=C1OC(=O)c2ccccc21>>Cc1cccc2c1c(/C=C1\OC(=O)c3ccccc31)cn2C,,O,,CC(=O)[O-].[Na+],,val
US20110065706A1,ClCCN1CCOCC1.OCc1ccc(S)cc1>>OCc1ccc(SCCN2CCOCC2)cc1,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20040044008A1,N#Cc1cccc(C2OCCO2)c1.O>>NC(=O)c1cccc(C2OCCO2)c1,,CCO,O,[Na+].[OH-],,val
US20150025070A1,O=C(O)CBr.O=C1c2ccc(F)cc2CC12CCNCC2>>O=C(O)CN1CCC2(CC1)Cc1cc(F)ccc1C2=O,,CC#N,CCOC(C)=O,CCN(CC)CC,,val
US20090298824A1,COC(=O)c1cc(C#N)cc2nc(Nc3cccc(Cl)c3Cl)[nH]c12>>N#Cc1cc(C(=O)O)c2[nH]c(Nc3cccc(Cl)c3Cl)nc2c1,,C1CCOC1,O,[Li+].[OH-],,val
US20150266867A1,C[C@@H]1CN(C[C@@H]2[C@H](NC(=O)/C(=N\OC(C)(C)C(=O)OC(C)(C)C)c3csc(NC(=O)OC(C)(C)C)n3)C(=O)N2S(=O)(=O)O)C(=O)O1>>C[C@@H]1CN(C[C@@H]2[C@H](NC(=O)/C(=N\OC(C)(C)C(=O)O)c3csc(N)n3)C(=O)N2S(=O)(=O)O)C(=O)O1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090069400A1,CC(C)S(=O)(=O)Cl.CC(C)n1cc(-c2ccc(C#N)c(F)c2)c2ccc(N)cc21>>CC(C)n1cc(-c2ccc(C#N)c(F)c2)c2ccc(NS(=O)C(C)C)cc21,,ClCCl,,CCN(CC)CC,,val
US20090197864A1,C[C@@H](Oc1c(N)ncc2c(Br)coc12)c1c(Cl)ccc(F)c1Cl.O=Cc1ccc(B(O)O)s1>>C[C@@H](Oc1c(N)ncc2c(-c3ccc(C=O)s3)coc12)c1c(Cl)ccc(F)c1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US05250551,ClCc1cccc(Cl)c1.N#Cc1ccc(O)cc1>>N#Cc1ccc(OCc2cccc(Cl)c2)cc1,,CN(C)C=O,O,[H][H],[H-].[Na+],val
US20150291584A1,C=C[Mg]Br.O=C(O)c1cccc([N+](=O)[O-])c1Cl>>O=C(O)c1ccc2cc[nH]c2c1Cl,,C1CCOC1,,Cl,[Cl-].[NH4+],val
US06018062,C[C@]12CC[C@@H]3c4ccc(OC5CCCCO5)cc4CC[C@@H]3[C@@H]1CCC2=C(F)F>>C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@@H]3[C@@H]1CCC2=C(F)F,,CO,O,O=C(O)C(=O)O,,val
US20110015175A1,Cc1ncnn1-c1ccc(Nc2n[nH]c(C(CCCCCl)c3ccc(F)cc3)n2)cc1F>>Cc1ncnn1-c1ccc(Nc2nc3n(n2)CCCCC3c2ccc(F)cc2)cc1F,,CC(C)=O,,[I-].[Na+],,val
US20070161673A1,CCNC(=O)c1ccc(C)c(-c2ccc(C(=O)c3ccc(F)cc3)c(Cl)n2)c1.NN>>CCNC(=O)c1ccc(C)c(-c2ccc3c(-c4ccc(F)cc4)n[nH]c3n2)c1,,C1CCOC1,,O,,val
US20050250782A1,Cn1cc(C(=O)NN)c(Nc2ccc(Br)cc2F)c(F)c1=O.N#CBr>>Cn1cc(-c2nnc(N)o2)c(Nc2ccc(Br)cc2F)c(F)c1=O,,C1COCCO1,O,O=C([O-])O.[Na+],,val
US05023275,CC(CSSCC(C)C(=O)Nc1ccccc1)C(=O)Nc1ccccc1.ClCl>>Cc1c(Cl)sn(-c2ccccc2)c1=O,,CCO,,CCOC(C)=O,,val
US05990102,CC(=O)OC1CC(=O)N1.SCc1ccccc1>>O=C1CC(SCc2ccccc2)N1,,CCO,,[Na],,val
US20090181948A1,C1CCNCC1.CS(=O)(=O)OCCCN1CCN(C2CCN(C3CC3)CC2)C1=C(C#N)C#N>>N#CC(C#N)=C1N(CCCN2CCCCC2)CCN1C1CCN(C2CC2)CC1,,C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US05668291,CC(=O)Nc1ccc(SSc2ccc(NC(C)=O)cc2C(=O)NC(CC(C)C)C(=O)OC(C)(C)C)c(C(=O)NC(CC(C)C)C(=O)OC(C)(C)C)c1>>CC(=O)Nc1ccc(SSc2ccc(NC(C)=O)cc2C(=O)NC(CC(C)C)C(=O)O)c(C(=O)NC(CC(C)C)C(=O)O)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120171245A1,CCCS(=O)(=O)Cl.Fc1cnc(-c2c[nH]c3ncc(Cl)cc23)nc1NC1CCCNC1>>CCCS(=O)(=O)N1CCC[C@@H](Nc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)C1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20060128715A1,CC(=O)NC(Cc1cc(F)cc(F)c1)C(O)CNC1(c2cccc(C(C)(C)C)c2)CCC(=O)CC1.CCCCCCCCOP(=O)(CC(=O)N(C)C)OCCCCCCCC>>CC(=O)NC(Cc1cc(F)cc(F)c1)C(O)CNC1(c2cccc(C(C)(C)C)c2)CCC(=CC(=O)N(C)C)CC1,,C1CCOC1,,[H-].[Na+],,val
US20060004108A1,CC1(C)C2CC[C@]1(C)C(=O)CC2=O.O=C=Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CC1(C)C2CC[C@]1(C)C(=O)C(C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2=O,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,Cl,val
US20100144760A1,CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2C[C@H]1CO.O=C1NC(=O)c2ccccc21>>CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2C[C@H]1CN1C(=O)c2ccccc2C1=O,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20060148800A1,N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-]>>NC(=O)c1c(N)cccc1N,,C1CCOC1,,O=S(=O)(O)O,[Na+].[OH-],val
US20070299039A1,CNc1ccc(Oc2ccnc(C(=O)NCCO)c2)cc1[N+](=O)[O-]>>CNc1ccc(Oc2ccnc(C(=O)NCCO)c2)cc1N,[Pd],CO,,,,val
US20070232627A1,Cc1cc(C)c2c(c1)OC(=O)CC2(C)C>>Cc1cc(C)c(C(C)(C)CCO)c(O)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030114491A1,C=CN1CCCC1=O.ON=CCCN1CCCCC1>>O=C1CCCN1C1CC(CCN2CCCCC2)=NO1,,ClC(Cl)Cl,,[Na+].[O-]Cl,,val
US04125622,C=[N+]=[N-].CCCCCC1(C)CSC(CC(=O)O)C(=O)O1>>CCCCCC1(C)CSC(CC(=O)OC)C(=O)O1,,CCOCC,,,,val
US05681841,CCOC(=O)CCc1ccc(N2CCN(c3ccc(Br)cc3)C2=O)cc1>>O=C(O)CCc1ccc(N2CCN(c3ccc(Br)cc3)C2=O)cc1,,O,,C1CCOC1,[Na+].[OH-],val
US04021542,Cc1cc(C)n([C@H]2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)n1>>Cc1cc(C)n([C@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)n1,[Pd],CO,Cl,,,val
US20120115848A1,CC[C@@H]1c2nncn2-c2cnc(-c3ccncc3N)nc2N1C1CCCC1.O=C(O)c1ccccc1>>CC[C@@H]1c2nncn2-c2cnc(-c3ccncc3NC(=O)c3ccccc3)nc2N1C1CCCC1,,C1CCOC1,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140018319A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1cc(N)c(Cl)c(NC2CCNCC2)c1>>CC(C)(C)OC(=O)N1CCC(Nc2cc(C#N)cc(N)c2Cl)CC1,,ClCCl,,,,val
US20020128255A1,CCOC(=O)c1cc(C(=O)[O-])cc(C(=O)OCC)c1>>CCOC(=O)c1cc(CO)cc(C(=O)OCC)c1,,C1CCOC1,,CO,,val
US20090221556A1,NCc1cccnc1.O=[N+]([O-])c1c(Cl)nc2ccccc2c1Cl>>O=[N+]([O-])c1c(Cl)nc2ccccc2c1NCc1cccnc1,,CN(C)C=O,,CCN(CC)CC,,val
US20080242665A1,C1=COCCC1.O=C(CO)N1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1>>O=C(COC1CCCCO1)N1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1,,CCOC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150175539A1,CCOC(=O)c1cc2c(C#N)cc(C#N)cc2[nH]1>>N#Cc1cc(C#N)c2cc(C(=O)O)[nH]c2c1,,CCO,O,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US05272147,C1COCCN1.CCCOc1ccc(CCl)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1>>CCCOc1ccc(CN2CCOCC2)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1,,CCC(C)=O,,CCCCCC,,val
US20090221604A1,CCOC(=O)c1sc(N2CCN(c3ccc(OC)cc3)CC2)nc1-c1ccccc1>>COc1ccc(N2CCN(c3nc(-c4ccccc4)c(CO)s3)CC2)cc1,,C1CCOC1,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05484763,COc1ccccc1C(=O)c1cc([N+](=O)[O-])ccc1Cl.CS>>COc1ccccc1C(=O)c1cc([N+](=O)[O-])ccc1SC,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US05244867,CC(C)(C)N.CCOC(=O)c1nc(SC)sc1C(=O)Cl>>CCOC(=O)c1nc(SC)sc1C(=O)NC(C)(C)C,,ClCCl,,Cl,,val
US20040067955A1,CC(C)n1nc(-c2cc(C#N)c(=O)[nH]c2-c2ccccc2)ccc1=O.OO>>CC(C)n1nc(-c2cc(C(N)=O)c(=O)[nH]c2-c2ccccc2)ccc1=O,,CCOC(C)=O,CS(C)=O,Cl,O=C([O-])[O-].[K+].[K+],val
US04663453,CCOC(=O)N1CCNCC1.O=C1Nc2cc(Br)ccc2N2CCc3cccc1c32>>CCOC(=O)N1CCN(C2=Nc3cc(Br)ccc3N3CCc4cccc2c43)CC1,Cl[Ti](Cl)(Cl)Cl,Cc1ccccc1,,[Na+].[OH-],,val
US20080242663A1,CI.COc1ccc(CO)c(Nc2ccnc(Cl)n2)c1>>COc1ccc(CO)c(N(C)c2ccnc(Cl)n2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070004753A1,CC(C)(O)C#N.Nc1ccc(C(F)(F)F)cc1>>CC(C)(C#N)Nc1ccc(C(F)(F)F)cc1,,CCOC(C)=O,,O=S(=O)([O-])[O-].[Mg+2],,val
US20080188472A1,NNC(=O)c1cc2cc(Cl)ccc2[nH]1.O=C(Cl)N1CCOCC1>>O=C(NNC(=O)N1CCOCC1)c1cc2cc(Cl)ccc2[nH]1,,C1CCOC1,CCOC(C)=O,CCN(C(C)C)C(C)C,,val
US20060041149A1,O=C(C(F)(F)F)C(F)(F)F.Oc1ccccc1>>Oc1ccccc1C(O)(C(F)(F)F)C(F)(F)F,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100280071A1,CCO[C@H]1CC[C@@H](N2CCC(Nc3cc(C)ccc3[N+](=O)[O-])CC2)CC1>>CCO[C@@H]1CC[C@H](N2CCC(Nc3cc(C)ccc3N)CC2)CC1,[Ni],CCO,,NN,O,val
US20070225318A1,CC(=O)N1CCc2ncc([N+](=O)[O-])cc2C1>>CC(=O)N1CCc2ncc(N)cc2C1,[Pd],CO,,,,val
US04698349,CCOC(=O)c1cc(C(=O)OCC)c2ccccn2c1=O>>O=C(O)c1cc(C(=O)O)c2ccccn2c1=O,,CO,,Cl,[Na+].[OH-],val
US20080004271A1,CC[C@@H](N)CO.COc1cccc(-c2nc(S(C)=O)nc3sc(C(N)=O)c(N)c23)c1F>>CC[C@H](CO)Nc1nc(-c2cccc(O)c2F)c2c(N)c(C(N)=O)sc2n1,,CN(C)C=O,,O,,val
US04332948,CN(N)c1ccccc1.O=Cc1ccc2ccccc2c1>>CN(N=Cc1ccc2ccccc2c1)c1ccccc1,Cl,CCO,,,,val
US20060051758A1,CC(=O)C(C)CCCCS(=O)(=O)O.NNc1ccc(S(=O)(=O)O)cc1>>CC1=Nc2ccc(S(=O)(=O)O)cc2C1(C)CCCCS(=O)(=O)O,,CC(=O)O,,,,val
US20080280950A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(OCCC(F)(F)F)cc2)CC1>>FC(F)(F)CCOc1ccc(OC2CCNCC2)cc1,,C1COCCO1,,Cl,,val
US04204867,Nc1ccccc1.O=C(CBr)c1ccccc1>>O=C(CNc1ccccc1)c1ccccc1,,CCO,,,,val
US04159984,COC(=O)C1OC2C(C(=O)N2C(C(=O)OCc2ccccc2)=C(C)C)N1C(=O)c1ccccc1>>CC(C)=C(C(=O)OCc1ccccc1)N1C(=O)C2C1OC(C(=O)O)N2C(=O)c1ccccc1,,CC(C)=O,O,[Na+].[OH-],,val
US20120108618A1,CC=CC(=O)OCC.CCOC(=O)CC(C)=O>>COC(=O)C1=C(O)CC(=O)CC1C,,CO,,CO[Na],,val
US20100298373A1,CC(C)(C)C1c2cccc(C(=N)NO)c2CCN1C(=O)[O-].COC(=O)c1ccc(OC(C)C)c(Cl)c1>>CC(C)Oc1ccc(-c2nc(-c3cccc4c3CCN(C(=O)OC(C)(C)C)C4)no2)cc1Cl,,C1CCOC1,,[H-].[Na+],,val
US20160024053A1,Fc1ccccc1-c1cnc(Cl)nc1.O=C(c1ccc2c(I)c[nH]c2c1)N1CCOCC1>>O=C(c1ccc2c(I)cn(-c3ncc(-c4ccccc4F)cn3)c2c1)N1CCOCC1,,CN(C)C=O,O,CC(C)(C)[O-].[K+],,val
US20040167122A1,CN1CCN(c2cc(Cl)cc(CS(=O)(=O)c3ccc(F)cc3)c2[N+](=O)[O-])CC1>>CN1CCN(c2cc(Cl)cc(CS(=O)(=O)c3ccc(F)cc3)c2N)CC1,,CO,,Cl,[Na+].[OH-],val
US20160168090A1,CC(C)(C)OC(=O)N1CCC(n2cc(C(=O)NCC3CCC(F)(F)CC3)c3c(Cl)cccc32)C1>>O=C(NCC1CCC(F)(F)CC1)c1cn(C2CCNC2)c2cccc(Cl)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070066583A1,COc1cc(N2CCN(C(=O)CCl)CC2)ccc1Cl.O=c1[nH]c2ccc(F)cc2o1>>COc1cc(N2CCN(C(=O)Cn3c(=O)oc4cc(F)ccc43)CC2)ccc1Cl,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20160176868A1,CC(=O)c1cccc(F)c1.CC(C)(C)[S@@](N)=O>>C/C(=N\[S@@](=O)C(C)(C)C)c1cccc(F)c1,,C1CCOC1,,CCOC(C)=O,O,val
US20080045530A1,COC(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1C(C)(C)O[SiH2]C(C)(C)C>>COC(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1CO,,c1ccncc1,,O,,val
US20160222014A1,O=[N+]([O-])c1ccc(F)cc1.OCC1CCCNC1>>O=[N+]([O-])c1ccc(N2CCCC(CO)C2)cc1,,CS(C)=O,,,,val
US06387935B1,CC(C)(C)c1ccc(OCC(N)=S)cc1.O=C1c2ccc(Cl)cc2CC1Br>>CC(C)(C)c1ccc(OCC2=NC3(O)c4ccc(Cl)cc4CC3S2)cc1,,CC(C)=O,,,,val
US20040209921A1,CC(=O)OC(C)=O.Cc1cccnc1CN(Cc1ncccc1C)C1CCNCC1>>CC(=O)N1CCC(N(Cc2ncccc2C)Cc2ncccc2C)CC1,,CC#N,,CCN(CC)CC,,val
US20090258888A1,CC1(C)OB(/C=C/c2ccc([N+](=O)[O-])cc2)OC1(C)C.Nc1nc(Cl)cc(Nc2ccc(Oc3ccnc(C(F)(F)F)c3)cc2)n1>>Nc1nc(/C=C/c2ccc([N+](=O)[O-])cc2)cc(Nc2ccc(Oc3ccnc(C(F)(F)F)c3)cc2)n1,,CC(=O)N(C)C,,O=C([O-])[O-].[Na+].[Na+],,val
US20140323463A1,CC(Cl)OC(=O)Cl.CN1CCN(C2CCN(c3ccc([N+](=O)[O-])cc3)CC2)CC1>>Cl.O=[N+]([O-])c1ccc(N2CCC(N3CCNCC3)CC2)cc1,,ClCCCl,,,,val
US06265572B1,COC(=O)C[C@H](c1ccc(OC)cc1)[C@@H]1N=C(OC)[C@@H](C(C)C)N=C1OC>>COC1=N[C@@H]([C@H](CCO)c2ccc(OC)cc2)C(OC)=N[C@@H]1C(C)C,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070093521A1,CCOc1cc(CN2CCC(Nc3nc4cccc(N)c4o3)CC2)cc(OCC)c1F.O=C(O)c1cncnc1>>CCOc1cc(CN2CCC(Nc3nc4cccc(NC(=O)c5cncnc5)c4o3)CC2)cc(OCC)c1F,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20160214978A1,COP(=O)(Cl)OC.Cc1nc2ccc(F)cc2n1-c1cc(N)nc(Nc2ccc(C(F)(F)F)cc2)n1>>COP(=O)(Nc1cc(-n2c(C)nc3ccc(F)cc32)nc(Nc2ccc(C(F)(F)F)cc2)n1)OC,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US05489593,CCC(=O)CC.Nc1cccnc1N1CCN(C(=O)OCc2ccccc2)CC1>>CCC(CC)Nc1cccnc1N1CCN(C(=O)OCc2ccccc2)CC1,,CO,,CC(=O)O,,val
US04171370,C=CCOCc1ccc(O)cc1.COc1ccc(CCNCC(O)CCl)cc1OC>>C=CCOCc1ccc(OCC(O)CNCCc2ccc(OC)c(OC)c2)cc1.Cl,,O,,CCO,[Na+].[OH-],val
US20100239525A1,CCCCNC.CS(=O)(=O)OCCc1ccc(Nc2ncc3c(n2)-c2ccccc2[C@H](c2ccc(F)cc2)C3)cc1>>CCCCN(C)CCc1ccc(Nc2ncc3c(n2)-c2ccccc2[C@H](c2ccc(F)cc2)C3)cc1,,CCN(CC)CC,,,,val
US20160096827A1,C1CN(C2COC2)CCN1.Cc1cc([N+](=O)[O-])ccc1F>>Cc1cc([N+](=O)[O-])ccc1N1CCN(C2COC2)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090253763A1,C/C(C=NO)=C\[C@@H]1[C@@H](C(=O)OC(C)(C)C)C1(C)C.CCCI>>CCCON=C/C(C)=C/[C@@H]1[C@@H](C(=O)OC(C)(C)C)C1(C)C,,CN(C)C=O,,Cl,[Na+].[OH-],val
US20120245144A1,C=C(OCC)c1cc2c(cc1F)OCCn1cc(-c3nc(C)nn3C(C)C)nc1-2>>CC(=O)c1cc2c(cc1F)OCCn1cc(-c3nc(C)nn3C(C)C)nc1-2,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04528114,CCCCCc1ccc(-c2ccc(C=C(Br)Br)cc2)cc1.N#COc1ccccc1>>CCCCCc1ccc(-c2ccc(C#CC#N)cc2)cc1,,C1CCOC1,CCCCCC,O,[Li]CCCC,val
US20150218150A1,CN1Cc2cc(-c3ccc(-c4cncc(N)c4)s3)ccc2C1=O.O=C(Cl)c1ccc(F)cc1F>>CN1Cc2cc(-c3ccc(-c4cncc(NC(=O)c5ccc(F)cc5F)c4)s3)ccc2C1=O,,ClCCl,c1ccncc1,,,val
US20100022550A1,N#Cc1ccc2[nH]c3c(c2c1)C[C@H](NC(=O)OCc1ccccc1)CC3>>N#Cc1ccc2[nH]c3c(c2c1)C[C@H](N)CC3,[Pd],CCO,,,,val
US20090131468A1,COC(=O)c1ccc(Br)c(OC(C)C)c1>>CC(C)Oc1cc(C(=O)O)ccc1Br,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20080292626A1,CCOC(=O)c1sc2ncccc2c1NC(=O)CC(C)C>>CC(C)CC(=O)Nc1c(C(=O)O)sc2ncccc12,,C1CCOC1,,[Li+].[OH-],,val
US20020111483A1,CCI.O=S(=O)(c1ccccc1)c1ccc2[nH]c3c(c2c1)CCN(Cc1ccccc1)CC3>>CCn1c2c(c3cc(S(=O)(=O)c4ccccc4)ccc31)CCN(Cc1ccccc1)CC2,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20140275003A1,C1COCCN1.Clc1cc(OCc2ccccc2)cc(Cl)n1>>Clc1cc(OCc2ccccc2)cc(N2CCOCC2)n1,,CN1CCCC1=O,,,,val
US20050171101A1,CC(C)(C)OC(=O)Nc1ccc(CCCOS(C)(=O)=O)cc1.[Br-]>>CC(C)(C)OC(=O)Nc1ccc(CCCBr)cc1,,CN(C)C=O,,CCOC(C)=O,O,val
US20160090381A1,Cc1c([N+](=O)[O-])cnc2c1ccn2C.O=C1CCC(=O)N1I>>Cc1c([N+](=O)[O-])cnc2c1c(I)cn2C,,CN(C)C=O,,O,,val
US20020160996A1,COc1ccc(S(=O)(=O)Cl)cc1.Cc1c(C)c2c(c(C)c1N)C(c1ccc(C(C)C)cc1)C(C)(C)O2>>COc1ccc(S(=O)(=O)Nc2c(C)c(C)c3c(c2C)C(c2ccc(C(C)C)cc2)C(C)(C)O3)cc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20090181942A1,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.COc1cccc(C(=O)c2cc(Cl)ccc2-n2cccc2C=O)c1F>>COC(=O)/C=C/c1cccn1-c1ccc(Cl)cc1C(=O)c1cccc(OC)c1F,,ClCCl,,Cc1ccccc1,,val
US20050277674A1,CN(C)C1(c2ccccc2)CCC(CN)CC1.O=C(Cl)Oc1ccccc1>>CN(C)C1(c2ccccc2)CCC(CNC(=O)Oc2ccccc2)CC1,,ClCCl,O,c1ccncc1,,val
US20070066624A1,CC(C)(C)OC(=O)CBr.Cc1nc(Oc2ccc(O)c(C(C)(C)C)c2)ccc1CN1CCC(N2C(=O)OC[C@H]2c2ccccc2)CC1>>Cc1nc(Oc2ccc(OCC(=O)OC(C)(C)C)c(C(C)(C)C)c2)ccc1CN1CCC(N2C(=O)OC[C@H]2c2ccccc2)CC1,,C1CCOC1,,[H-].[Na+],,val
US20150018328A1,NC(=O)c1ccccc1.O=C(Cl)Cl.SCl>>O=c1oc(-c2ccccc2)ns1,,Cc1ccccc1,,,,val
US20020132796A1,COc1ccc2c(c1)C(C)(C)CNC2.O=CO>>COc1ccc2c(c1)C(C)(C)CN(C=O)C2,,ClC(Cl)Cl,ClCCl,CCN=C=NCCCN(C)C,Cl,val
US20100240658A1,COC(=O)c1ccc(-c2ccccc2C)c(S(C)(=O)=O)c1>>Cc1ccccc1-c1ccc(C(=O)O)cc1S(C)(=O)=O,,C1CCOC1,CO,[Na+].[OH-],,val
US20060240190A1,C[Si](C)(C)C1([Na])C=CC=C1.Cl[Ru](Cl)C1=CCCC=CCC1.[Na]C1C=CC=C1>>C[Si](C)(C)[Ru](C1C=CC=C1)C1C=CC=C1,,C1CCOC1,,,,val
US20040010009A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(NC/C=C/c3cccc(C#N)c3)cc2)CC1.OC1COC(O)CO1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(N(C/C=C/c3cccc(C#N)c3)CCO)cc2)CC1,,ClCCl,O,CC(=O)O,[BH3-]C#N.[Na+],val
US20110281870A1,CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@H]1CC[C@@H]2CNC[C@H]12.FC(F)(F)c1ccnc(Br)c1>>CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@H]1CC[C@@H]2CN(c3cc(C(F)(F)F)ccn3)C[C@H]12,,CCO,,CCN(CC)CC,O,val
US05670653,COC(=O)C1OC(=O)NC1Cc1ccccc1>>COC(=O)[C@@H]1OC(=O)N[C@H]1Cc1ccccc1,,C1CCOC1,,,,val
US20020042415A1,CN1C[C@]2(Cc3ccc(F)cc3F)CN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)NC(=O)OC(C)(C)C)CCN2C1=O.Cl>>CN1C[C@]2(Cc3ccc(F)cc3F)CN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)CCN2C1=O.Cl,,CCO,,,,val
US05328911,CCS(=O)(=O)c1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1.CO>>COc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,ClCCl,,C[O-].[Na+],,val
US04267174,CC(=O)NCCCCCC(=O)O.N#CC1CN1>>CC(=O)NCCCCCC(=O)N1CC1C#N,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20090093483A1,CC(C)(C)OC(=O)CN.CCOC(=O)C1=C(O)c2ccc(F)c(F)c2C(C)(C)C1=O>>CC(C)(C)OC(=O)CNC(=O)C1=C(O)c2ccc(F)c(F)c2C(C)(C)C1=O,,C1COCCO1,,CCN(C(C)C)C(C)C,Cl,val
US08334292B1,CC(C)(C)OC(=O)N1CC(Oc2nc(Cl)ncc2Br)C1.C[C@@H]1CC[C@H](N)CC1>>C[C@@H]1CC[C@H](Nc2ncc(Br)c(OC3CN(C(=O)OC(C)(C)C)C3)n2)CC1,,CCO,,CCN(CC)CC,Cl,val
US20050054681A1,CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)n1cccn1.NCCOc1cc(=O)oc2ccccc12.O=C(O)C(F)(F)F>>N=C(N)NCCOc1cc(=O)oc2ccccc12.O=C(O)C(F)(F)F,,CC#N,,CCN(C(C)C)C(C)C,,val
US20080194640A1,C=Cn1cc(C(=O)OCC)cn1>>C=Cn1cc(C(=O)O)cn1,,CCO,,Cl,[Na+].[OH-],val
US20130157923A1,C=C(C)CCO.CC1CC(=O)CC(C)(C)C1>>CC1=CCOC2(C1)CC(C)CC(C)(C)C2,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,,,val
US20160185778A1,COc1ccc(Cn2nc(CO)c3c2CCN(C(=O)OC(C)(C)C)C3)cc1>>COc1ccc(Cn2nc(C=O)c3c2CCN(C(=O)OC(C)(C)C)C3)cc1,O=[Mn]=O,ClCCl,,,,val
US20090143385A1,Cc1onc(-c2ccccc2)c1CO.Clc1ccc2nncn2n1>>Cc1onc(-c2ccccc2)c1COc1ccc2nncn2n1,,CN(C)C=O,,[H-].[Na+],,val
US20150175602A1,CN(C)C(=O)Cl.COc1ccc(OC2CCN(c3nc4c(nc3NC3CCC3)CCNC4)CC2)c(F)c1.O=C(O)C(F)(F)F>>COc1ccc(OC2CCN(c3nc4c(nc3NC3CCC3)CCN(C(=O)N(C)C)C4)CC2)c(F)c1.O=C(O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20130281433A1,CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(N3CCN(C(=O)OC(C)(C)C)C(c4ccc5c(cnn5C)c4)C3)sc2c1-c1ccc(Cl)cc1>>Cc1cc2nc(N3CCN(C(=O)OC(C)(C)C)C(c4ccc5c(cnn5C)c4)C3)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O,,C1CCOC1,CO,CC(=O)O,[Na+].[OH-],val
US20130018034A1,CC(C)NC(=O)c1ccc(N2CC(=O)C2)cc1.CCOP(=O)(CC#N)OCC>>CC(C)NC(=O)c1ccc(N2CC(=CC#N)C2)cc1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US05919779,BrBr.CCNc1ncccc1-c1snnc1-c1cccnc1Cl>>CCNc1ncc(Br)cc1-c1snnc1-c1cccnc1Cl,,CC(=O)O,CCOC(C)=O,CC(=O)[O-].[Na+],,val
US20120283297A1,CC(C)I.COC(=O)c1c[nH]c(=O)c(C#N)c1>>COC(=O)c1cnc(OC(C)C)c(C#N)c1,,CN(C)C=O,,O,[Cs+].[F-],val
US04654347,CC(=O)c1cccc(N)c1.COC(=O)Cl>>COC(=O)Nc1cccc(C(C)=O)c1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04609650,CCC(O)C(=O)O.CC[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]2(C)[C@H]1OC(=O)CBr>>CCC(O)C(=O)OCC(=O)O[C@H]1[C@@H](CC)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C,,CN(C)C=O,,CCOC(C)=O,[Na+].[OH-],val
US20050143422A1,Nc1ccc(Br)cc1.O=C(Cl)c1cc2ccccc2o1>>O=C(Nc1ccc(Br)cc1)c1cc2ccccc2o1,,ClCCl,,CCN(CC)CC,,val
US05929072,C=CCN1c2ccccc2C(C)NS1(=O)=O.C[Mg]Br>>C=CCN1c2ccccc2C(C)(C)NS1(=O)=O,,C1CCOC1,,O,,val
US20110021537A1,O=C(N[C@@H](CCCCOCc1ccccc1)C(=O)N1CCN(C(=O)OC2CCC2)CC1)OCC1c2ccccc2-c2ccccc21>>N[C@@H](CCCCOCc1ccccc1)C(=O)N1CCN(C(=O)OC2CCC2)CC1,,CN(C)C=O,,C1COCCN1,,val
US06582351B1,Nc1cc(C(F)(F)F)ccc1N[C@@H]1CC[C@@H](O)CC1.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]c2cc(C(F)(F)F)ccc2n1[C@@H]1CC[C@@H](O)CC1,,CC#N,,Cl,[Na+].[OH-],val
US05021449,CCN1CCCC1CNC(=O)c1sc(C=O)c(C)c1OC>>CCN1CCCC1CNC(=O)c1sc(CO)c(C)c1OC,,CCO,,O,[BH4-].[Na+],val
US20050176689A1,Cc1cc2c(cc1O)C(C)(C)CCC2=O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cc2c(cc1OS(=O)(=O)C(F)(F)F)C(C)(C)CCC2=O,CN(C)c1ccncc1,CCCCCC,ClCCl,CCOC(C)=O,,val
US20140148340A1,O=Cc1ccc(-c2nccc(Cl)n2)cc1.OB(O)c1ccc(OC(F)(F)F)cc1>>O=Cc1ccc(-c2nccc(-c3ccc(OC(F)(F)F)cc3)n2)cc1,[Pd],,,,,val
US05608056,C=CCOC(=O)C1=C(S[C@H]2C[C@@H](CCn3cnc(C#N)c3)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12.COS(=O)(=O)C(F)(F)F>>C=CCOC(=O)C1=C(S[C@H]2C[C@@H](CC[n+]3cc(C#N)n(C)c3)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12.O=S(=O)([O-])C(F)(F)F,,ClCCl,,,,val
US20150025056A1,COC(=O)[C@H]1C[C@@H](O)CC[C@@H]1C(=O)N1CCN(c2ccccc2)CC1.Oc1ccccc1>>COC(=O)[C@H]1C[C@H](Oc2ccccc2)CC[C@@H]1C(=O)N1CCN(c2ccccc2)CC1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100152160A1,CC(C)(C)OC(=O)N1CCC(C#N)(C(F)(F)c2ccc(F)cc2)CC1>>N#CC1(C(F)(F)c2ccc(F)cc2)CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060069132A1,CCNC(=O)c1cc([N+](=O)[O-])ccc1F>>CCNC(=O)c1cc(N)ccc1F,[Fe],CC(=O)O,,,,val
US04866182,CCCCC(=O)Cl.Cc1coc(=O)[nH]1>>CCCCC(=O)c1oc(=O)[nH]c1C,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20100216779A1,COc1cc(N2CCN(C3CCN(C(=O)[O-])C(C(C)(C)C)C3)CC2)ccc1[N+](=O)[O-]>>COc1cc(N2CCN(C3CCNCC3)CC2)ccc1[N+](=O)[O-],,ClCCl,,O=C(O)C(F)(F)F,,val
US20150045355A1,CC(C)(C)OC(=O)Nc1cc(F)ccn1.CN(C)C=O>>CC(C)(C)OC(=O)Nc1nccc(F)c1C=O,,C1CCOC1,,[Li]CCCC,,val
US20090253687A1,ClI.O=C/C=C\c1ccc(F)cc1F>>O=C/C(I)=C/c1ccc(F)cc1F,,ClCCl,c1ccncc1,,,val
US04318917,FC(F)(F)C1(C(F)(F)F)SC(C(F)(F)F)(C(F)(F)F)S1.c1ccc(-c2cc[nH]c2-c2ccccc2)cc1>>FC(F)(F)C(c1cc(-c2ccccc2)c(-c2ccccc2)[nH]1)C(F)(F)F,,CCOCC,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20130184253A1,CCn1nc(C2CC2)cc1N.COc1nc(Cl)c(C=O)c(OC)n1>>CCn1nc(C2CC2)cc1NCc1c(Cl)nc(OC)nc1OC,,C1CCOC1,,[BH4-].[Na+],,val
US20040254167A1,COC1=N[C@@H](C(C)C)C(OC)=NC1.Fc1cc(C(F)(F)F)ccc1CBr>>COC1=N[C@@H](C(C)C)C(OC)=N[C@@H]1Cc1ccc(C(F)(F)F)cc1F,,C1CCOC1,,[Li]CCCC,,val
US04732978,ClCc1ccc2ccccc2n1.Oc1cccc(C(F)(F)F)c1>>FC(F)(F)c1cccc(OCc2ccc3ccccc3n2)c1,,CO,,C[O-].[Na+],,val
US20150038488A1,CNc1c(OCc2ccccc2)cc(Br)cc1[N+](=O)[O-].O=CO>>Cn1cnc2cc(Br)cc(OCc3ccccc3)c21,[Fe],O=CO,,CCO,,val
US20030013720A1,CN1CCC(C(=O)NCc2cc(Cl)cc(Cl)c2)(c2ccc(I)cc2)CC1.N#Cc1cccc(B(O)O)c1>>CN1CCC(C(=O)NCc2cc(Cl)cc(Cl)c2)(c2ccc(-c3cccc(C#N)c3)cc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,CCO,O=C([O-])[O-].[Na+].[Na+],val
US20070032478A1,CC(=O)Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3=CO)c1.Cn1cc(C(=O)Cl)c(C(F)(F)F)n1>>Cn1cc(C(=O)Nc2cccc(C(=O)c3ccc4c(c3)NC(=O)C4)c2)c(C(F)(F)F)n1,,C1CCOC1,,,,val
US20150111882A1,C=C[Mg]Cl.O=C1CCCc2sccc21>>C=CC1(O)CCCc2sccc21,,CCOCC,,[Cl-].[NH4+],,val
US20100222352A1,Cc1ccccc1CBr.Oc1cc(Nc2nccs2)ccc1Cl>>Cc1ccccc1COc1cc(Nc2nccs2)ccc1Cl,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120122764A1,Cc1cccc(-c2ccc(C[C@H](NC(=O)C3(CC(=O)OCc4ccccc4)CCCC3)c3nnn[nH]3)cc2)c1>>Cc1cccc(-c2ccc(C[C@H](NC(=O)C3(CC(=O)O)CCCC3)c3nnn[nH]3)cc2)c1,[Pd],CO,,,,val
US20090023713A1,BrCCCOCc1ccccc1.NCCO>>OCCNCCCOCc1ccccc1,,CCO,,[I-].[Na+],,val
US20130289058A1,COC(=O)C=C1CCC(CO)(c2ccc(Br)cc2)CC1>>COC(=O)CC12CCC(c3ccc(Br)cc3)(CC1)CO2,,C1COCCO1,,[H-].[Na+],,val
US20130085142A1,CC(C)(C)OC(=O)N1C[C@H](Oc2cnc(C3CC3)cn2)C[C@H]1CN.COC(=O)CBr>>COC(=O)CNC[C@@H]1C[C@@H](Oc2cnc(C3CC3)cn2)CN1C(=O)OC(C)(C)C,,CO,,CCN(CC)CC,,val
US04110455,CCOC(=O)CC(=O)OCC.O=C(c1ccccc1)c1nc(Cl)ccc1[N+](=O)[O-]>>Cc1ccc([N+](=O)[O-])c(C(=O)c2ccccc2)n1,,C1COCCO1,,[H-].[Na+],,val
US20100273786A1,CC(C)(C)OC(=O)NC1CCCNC1.CC(C)(C)OC(=O)N[C@@H](CC(=O)N1CCn2c(C(F)(F)F)nc(C(=O)O)c2C1)Cc1cc(F)c(F)cc1F>>CC(C)(C)OC(=O)NC(CC(=O)N1CCn2c(C(F)(F)F)nc(C(=O)N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)c2C1)Cc1cc(F)c(F)cc1F,,ClCCl,,CCN(CC)CC,O=C1OCCN1P(=O)(Cl)N1CCOC1=O,val
US20030130328A1,Nc1cc[nH]n1.O=C1Nc2ccccc2/C1=C/O>>O=C1Nc2ccccc2C1=CNc1cc[nH]n1,,C1CCOC1,,,,val
US03986877,C=CC(=O)OCCSCC.C=CC(N)=O>>C=CC(=O)OCCSCC.C=CC(N)=O,,CC(C)O,O,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20050209213A1,CC(=O)OC(C)=O.Nc1cccc([N+](=O)[O-])c1F>>CC(=O)Nc1cccc([N+](=O)[O-])c1F,,c1ccncc1,,,,val
US05756799,C=C(NC(C)=O)C(=O)O>>CC(=O)N[C@H](C)C(=O)O,,CO,,,,val
US20090105266A1,CCCNc1cccc(C)c1[N+](=O)[O-]>>CCCNc1cccc(C)c1N,[Pd],C1CCOC1,,,,val
US20130274255A1,NN.O=C(c1cccnc1)C1Cc2sccc2C1=O>>c1cncc(-c2n[nH]c3c2Cc2sccc2-3)c1,,CCO,,CC(=O)O,O,val
US20120295875A1,CCOC(=O)C(Br)CC.OB1OCc2ccc(O)cc21>>CCOC(=O)C(CC)Oc1ccc2c(c1)B(O)OC2,,CN(C)C=O,,Cl,[H-].[Na+],val
US20110118238A1,CC(C)(C)OC(=O)N1CCC(N)CC1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>CC(C)(C)OC(=O)N1CCC(Nc2nc(Cl)ncc2[N+](=O)[O-])CC1,,CCOC(C)=O,,CCN(C(C)C)C(C)C,,val
US05658920,CC(=O)Nc1ccc(Cl)c2c1C(=O)C(=CO)CC2.NO>>CC(=O)Nc1ccc(Cl)c2c1-c1cnoc1CC2,,O,,CC(=O)O,Cl,val
US20100305124A1,Cc1ccc(C(=O)N(C)c2cccnc2)cc1[N+](=O)[O-]>>Cc1ccc(C(=O)N(C)c2cccnc2)cc1N,,CCO,CCO,Cl[Sn]Cl,,val
US20090163488A1,CN1CCNCC1.Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Oc1ccc2nc(N)nn2c1.O=C(Cl)CCCCl>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Oc1ccc2nc(NC(=O)CCCN3CCN(C)CC3)nn2c1,,CN(C)C=O,O,CCN(CC)CC,O=C([O-])O.[Na+],val
US04071685,CON(C)C(=O)Cl.O=C1CNC(=O)N1c1cc(Cl)cc(Cl)c1>>CON(C)C(=O)N1CC(=O)N(c2cc(Cl)cc(Cl)c2)C1=O,,C1CCOC1,,CCN(CC)CC,,val
US20050203064A1,NC(=S)C=Cc1ccc(SC(F)(F)F)cc1.O=C(CCl)CCl>>FC(F)(F)Sc1ccc(C=Cc2nc(CCl)cs2)cc1,,CC(C)=O,,,,val
US20110003787A1,CC(C)[Si](Cl)(C(C)C)C(C)C.COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc(-c2ccc(C(=O)N[C@H](CO)[C@@H](C)O)[nH]2)c1>>COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc(-c2ccc(C(=O)N[C@H](CO[Si](C(C)C)(C(C)C)C(C)C)[C@@H](C)O)[nH]2)c1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20140051679A1,CC1(C)OB(c2ccc(O)c(Cl)c2)OC1(C)C.CN1CCC(O)CC1>>CN1CCC(Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2Cl)CC1,,ClCCl,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20090105253A1,CCNC(=O)c1ccc(-n2nnc(C(=O)NC3CC3)c2COS(C)(=O)=O)cc1.NCc1ccccc1>>CCNC(=O)c1ccc(-n2nnc(C(=O)NC3CC3)c2CNCc2ccccc2)cc1,,CC#N,CCOC(C)=O,[I-].[K+],O=C([O-])O.[Na+],val
US20060293499A1,CC(C)(C)OC(=O)Nc1ccc2c(c1)C(C=O)c1cc(NC(=O)OC(C)(C)C)ccc1-2>>CC(C)(C)OC(=O)Nc1ccc2c(c1)C(CO)c1cc(NC(=O)OC(C)(C)C)ccc1-2,,CO,O,CC(=O)O,[BH4-].[Na+],val
US20050020605A1,CCO/N=C(\c1ccc(Br)cc1)C1CCN(C2(C)CCNCC2)CC1.Cn1ccc2cc(C(=O)O)ccc21>>CCO/N=C(\c1ccc(Br)cc1)C1CCN(C2(C)CCN(C(=O)c3ccc4c(ccn4C)c3)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100075964A1,CCOC(=O)C(=O)CBr.N=C(Nc1c(Cl)cccc1Cl)c1ccc(Br)s1>>CCOC(=O)c1cn(-c2c(Cl)cccc2Cl)c(-c2ccc(Br)s2)n1,,CC(C)O,,O=C([O-])O.[Na+],,val
US04306065,Clc1nc(-c2ccccc2)nc2ccccc12.OC1CCNCC1>>OC1CCN(c2nc(-c3ccccc3)nc3ccccc23)CC1,,CCO,,[Na+].[OH-],,val
US20060041146A1,CC[Mg]Cl.CON(C)C(=O)c1csc(NC(=O)OC(C)(C)C)n1>>CCC(=O)c1csc(NC(=O)OC(C)(C)C)n1,,C1CCOC1,,,,val
US20080108102A1,CCI.CN(C)c1ccc(-c2ccncc2)cc1>>CC[n+]1ccc(-c2ccc(N(C)C)cc2)cc1.[I-],,CC#N,,CCOCC,,val
US20110237578A1,CCCC[Sn](CCCC)(CCCC)c1ccc(C)cn1.Cc1ccc(-c2cc(Br)cc(C(=O)NCc3cnc(C)nc3)c2)cc1>>Cc1ccc(-c2cc(C(=O)NCc3cnc(C)nc3)cc(-c3ccc(C)cn3)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,Cc1ccccc1,,val
US04874894,CCc1ccccc1.O=P(Cl)(Cl)Cl.O=S(=O)(O)O>>CCc1ccc(S(=O)(=O)Cl)cc1,,O,,,,val
US05204344,BrCc1ccc2ccccc2n1.COC(=O)C(C)(C)Cc1cc2cc(O)ccc2[nH]1>>COC(=O)C(C)(C)Cc1cc2cc(OCc3ccc4ccccc4n3)ccc2[nH]1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04363816,Cc1cn(C)c2c1Nc1ccccc1NC2=O.O=C(Cl)CCl>>Cc1cn(C)c2c1N(C(=O)CCl)c1ccccc1NC2=O,,C1COCCO1,,O=C([O-])[O-].[K+].[K+],,val
US06090803,CI.Cn1ccc(-c2ccc(C(=O)c3cccc4c3Nc3ncccc3CN4)c(Cl)c2)n1>>CC1Nc2cccc(C(=O)c3ccc(-c4ccn(C)n4)cc3Cl)c2Nc2ncccc21,,C1CCOC1,,CCCCCC,[H-].[Na+],val
US20040029917A1,CCOC(=O)CC(=O)OCC.Cc1ccccc1CCOS(C)(=O)=O>>CCOC(=O)C(CCc1ccccc1C)C(=O)OCC,,CCO,,C,C[O-].[Na+],val
US20040102450A1,Clc1nc(Cl)c(Cl)c(Cl)c1Cl.NCc1ccccc1>>Clc1nc(Cl)c(Cl)c(NCc2ccccc2)c1Cl,,C1COCCO1,,,,val
US04874542,CCCCCCCCOC(=O)Cl.CCCCCCCCOc1ccc(-c2ncc(O)cn2)cc1.c1ccncc1>>CCCCCCCCCCOc1ccc(-c2ncc(OC(=O)OCCCCCCCC)cn2)cc1,,ClC(Cl)(Cl)Cl,,Cl,,val
US20080119476A1,COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CNCC(O)c1ccc(Cl)cc1.O=C(OCc1ccccc1)OC(=O)OCc1ccccc1>>COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN(CC(O)c1ccc(Cl)cc1)C(=O)OCc1ccccc1,,ClCCl,,O,,val
US20030176418A1,CCCCCC1CC2CCC(C1)N2.Cc1ccc2c(c1)N(C[C@H](C)CI)C(=O)CO2>>CCCCCC1CC2CCC(C1)N2C[C@@H](C)CN1C(=O)COc2ccc(C)cc21,,CCN(CC)CC,,,,val
US20140088075A1,C1COCCN1.O=[N+]([O-])c1ccc(F)c(CBr)c1>>O=[N+]([O-])c1ccc(F)c(CN2CCOCC2)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20150210727A1,CC(=O)c1cccc(C(C)N=C=O)c1.O=C1N[C@H](Cc2ccccc2)CO1.[Li]CCCC>>CC1(c2cccc(C#N)c2)OCCO1,,C1CCOC1,,,,val
US20080139607A1,CCCCCCCc1cc(=O)n2c(c1-c1ccc(F)c(F)c1)SC[C@H]2C(=O)OC>>CCCCCCCc1cc(=O)n([C@@H](C)C(=O)OC)cc1-c1ccc(F)c(F)c1,[Ni],CO,,,,val
US05273999,CCCc1c(OCCCCCBr)ccc2c1OCCC2=O.CCOC(=O)CCc1cc(-c2cc3ccccc3c(=O)o2)ccc1O>>CCCc1c(OCCCCCOc2ccc(-c3cc4ccccc4c(=O)o3)cc2CCC(=O)OCC)ccc2c1OCCC2=O,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100295030A1,Brc1ccc2cc3ccccc3cc2c1.OB(O)c1ccc2c3ccccc3c3ccccc3c2c1>>c1ccc2cc3cc(-c4ccc5c6ccccc6c6ccccc6c5c4)ccc3cc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20040044056A1,CC(C)(C)OC(=O)N1CCNCC1.Nc1nc(Cl)ccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)N1CCN(c2cnc(N)c([N+](=O)[O-])c2)CC1,,CN1CCCC1=O,,O,O=C([O-])[O-].[K+].[K+],val
US20070249607A1,CC(C)(C)OC(=O)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccc(F)cc2Br)CC1.OB(O)c1ccccc1>>CC(C)(C)OC(=O)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccc(F)cc2-c2ccccc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20060111375A1,COc1cc2c(Oc3cc4cccnc4nc3C)ccnc2cc1OCCCl.OC1CCNCC1>>COc1cc2c(Oc3cc4cccnc4nc3C)ccnc2cc1OCCN1CCC(O)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110275611A1,CNc1nc(-c2ccc(C#N)c(F)c2)cc(N2C[C@@H](CN(C)C)OC[C@H]2C)n1.NN>>CNc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2C[C@@H](CN(C)C)OC[C@H]2C)n1,,C1COCCO1,,O,,val
US20110118245A1,COc1cc2ncnc(Sc3cccc(N)c3)c2cc1OC.COc1ccc(-n2nc(C(C)C)cc2NC(=O)Oc2ccccc2)cc1>>COc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2cccc(Sc3ncnc4cc(OC)c(OC)cc34)c2)cc1,CN(C)c1ccncc1,C1CCOC1,,,,val
US04005217,CN(C)CC(=O)Nc1ccccc1[N+](=O)[O-]>>CN(C)CC(=O)Nc1ccccc1N,O=[Pt],CCO,,[H][H],,val
US20070082872A1,COc1cc(C(=O)Cl)cc(OC)c1OC.COc1ccc2cc(-c3ccc(OC)c(O[Si](C)(C)C(C)(C)C)c3)[nH]c2c1>>O=C(c1ccccc1)c1cc2ccccc2[nH]1,,Clc1ccccc1Cl,,,,val
US20090286775A1,COc1ccc2c(c1)CCC(C)(C)C2=O>>CC1(C)CCc2cc(O)ccc2C1=O,,CCOCC,O,Br,,val
US05710139,COC(=O)c1cc2cc(Cl)c(Cl)cc2nc1O>>OCc1cc2cc(Cl)c(Cl)cc2nc1O,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20090137561A1,COc1ccc(F)c(-c2ccc(CCl)cc2C(C)(C)C)c1.Oc1cncc(Br)c1>>COc1ccc(F)c(-c2ccc(COc3cncc(Br)c3)cc2C(C)(C)C)c1,,CN(C)C=O,O,[H-].[Na+],,val
US20100210660A1,COC(=O)c1ccc(O)cc1.COc1ccc(Br)cn1>>COC(=O)c1ccc(Oc2ccc(OC)nc2)cc1,[Cu]I,c1ccncc1,,Cl,O=C([O-])[O-].[K+].[K+],val
US06284796B1,CC(C)(C)[Si](C)(C)OCCCO.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CC(C)(C)[Si](C)(C)OCCCOS(=O)(=O)c1ccc([N+](=O)[O-])cc1,,ClCCl,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US05998415,CC(Br)c1ccccc1.CC(C)(C)OC(=O)N1CCNC(=O)C1>>CC(c1ccccc1)N1CCN(C(=O)OC(C)(C)C)CC1=O,,CN(C)C=O,,[H-].[Na+],,val
US20150291528A1,CC(=O)Cl.COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=N)=O)ccn2)ncc1F>>COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=NC(C)=O)ccn2)ncc1F,,ClCCl,,CCN(CC)CC,,val
US20070287708A1,COc1ccc(-c2cncc(C#N)c2Cl)cc1OC.Oc1ccc2[nH]ccc2c1>>COc1ccc(-c2cncc(C#N)c2Oc2ccc3[nH]ccc3c2)cc1OC,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20060173019A1,COCN(c1cc(Cl)cnc1C(=O)N(C)c1ccc(F)cc1)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>CN(C(=O)c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1)c1ccc(F)cc1,,C1COCCO1,O,Cl,,val
US06228848B1,CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(c2ccc(C)s2)=CCC3(C)C)cc1>>Cc1ccc(C2=CCC(C)(C)c3ccc(CCc4ccc(C(=O)O)cc4)cc32)s1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US04410536,CC(C)N1CCC(=O)CC1.NNc1ccc2scc(-c3ccccc3)c2c1>>CC(C)N1CCc2[nH]c3ccc4scc(-c5ccccc5)c4c3c2C1,,CC(C)O,,Cl,Cl,val
US05730953,CC(C)(C)[Si](C)(C)OCCN(CCO[Si](C)(C)C(C)(C)C)S(=O)(=O)c1ccc([Bi](c2ccc(S(=O)(=O)N(CCO[Si](C)(C)C(C)(C)C)CCO[Si](C)(C)C(C)(C)C)cc2S(=O)(=O)N(CCO[Si](C)(C)C(C)(C)C)CCO[Si](C)(C)C(C)(C)C)c2ccc(S(=O)(=O)N(CCO[Si](C)(C)C(C)(C)C)CCO[Si](C)(C)C(C)(C)C)cc2S(=O)(=O)N(CCO[Si](C)(C)C(C)(C)C)CCO[Si](C)(C)C(C)(C)C)c(S(=O)(=O)N(CCO[Si](C)(C)C(C)(C)C)CCO[Si](C)(C)C(C)(C)C)c1>>O=S(=O)(c1ccc([Bi](c2ccc(S(=O)(=O)N(CCO)CCO)cc2S(=O)(=O)N(CCO)CCO)c2ccc(S(=O)(=O)N(CCO)CCO)cc2S(=O)(=O)N(CCO)CCO)c(S(=O)(=O)N(CCO)CCO)c1)N(CCO)CCO,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20020183512A1,CN(C)c1cccc(O)c1.O=C(O)CCCCOC1=CC(=O)C(=O)c2ccccc21>>CN(C)c1cccc(OC(=O)CCCCOC2=CC(=O)C(=O)c3ccccc32)c1,CN(C)c1ccncc1,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20140045936A1,CN.COC(=O)C1(c2ccc(-c3ccccc3)cc2)CC1C=O.Cl>>CNCC1CC1(C(=O)OC)c1ccc(-c2ccccc2)cc1.Cl,,CCOCC,CO,[BH4-].[Na+],,val
US20090062363A1,Cc1c(C)n(Cc2ccc(F)cc2)c2ccc(C(=O)NC3CCN(C(=O)OC(C)(C)C)C3)cc12.Cl>>Cc1c(C)n(Cc2ccc(F)cc2)c2ccc(C(=O)NC3CCNC3)cc12.Cl,,CCOC(C)=O,,CO,,val
US04411839,Cc1cccc(C)c1N(NC(N)=O)C(=O)CC#N>>Cc1cccc(C)c1Nn1c(N)cc(=O)[nH]c1=O,,CCO,,O,[Na+].[OH-],val
US20160185780A1,CC(C)(C)OC(=O)N1CCC(CC=O)(c2ccc(Cl)cc2)CC1>>CC(C)(C)OC(=O)N1CCC(CCO)(c2ccc(Cl)cc2)CC1,,CO,,[BH4-].[Na+],,val
US20070249607A1,C[C@@H](OCC1(c2ccccc2)CCN(C(=O)OC(C)(C)C)CC1)c1cc(-c2ccc(C#N)cc2)cc(C(F)(F)F)c1>>C[C@@H](OCC1(c2ccccc2)CCNCC1)c1cc(-c2ccc(C#N)cc2)cc(C(F)(F)F)c1,,O=C(O)C(F)(F)F,,,,val
US20150210677A1,NC1=C(O)C(=O)C(c2ccc(Cl)cc2)O1.O=C(Cl)Oc1ccccc1>>NC1=C(OC(=O)Oc2ccccc2)C(=O)C(c2ccc(Cl)cc2)O1,,C1CCOC1,,CCN(CC)CC,[Cl-].[NH4+],val
US20110224204A1,Cc1ccc(OC2CCCCO2)c(-c2ccncc2)c1>>Cc1ccc(O)c(-c2ccncc2)c1,,CO,,O=C(O)C(F)(F)F,,val
US20080096874A1,CCOC(=O)C(C)[C@@H]1CC[C@@H](c2ccc(N=C(c3ccccc3)c3ccccc3)cc2)CC1>>CCOC(=O)C(C)[C@@H]1CC[C@@H](c2ccc(N)cc2)CC1,[Pd],CCO,,,,val
US20110294776A1,CN(C)C(=O)CCl.Nc1ncnn2c(C3CNCCO3)cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c12>>CN(C)C(=O)CN1CCOC(c2cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c3c(N)ncnn23)C1,,CN(C)C=O,,[I-].[K+],,val
US20100221556A1,O=[Sb](=O)O[Sb](=O)=O.O=[Sn].[O-2].[O-2].[O-2].[O-2].[Ti+4].[Zr+4]>>O=[Sb](=O)O[Sb](=O)=O.O=[Sn].[O-2].[O-2].[O-2].[O-2].[Ti+4].[Zr+4],,O,,,,val
US20090137595A1,COC(=O)c1cccc(O)c1.O=C(Nc1cn2nc(I)ccc2n1)C1CC1>>COC(=O)c1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080171754A1,CN(C)c1cccc(C(=O)O)c1.O=C1CCC(=O)N1Br>>CN(C)c1ccc(Br)c(C(=O)O)c1,,CN(C)C=O,,O,,val
US20110178063A1,CC(C)n1nccc1C(=O)Nc1cc(Br)cc2nn(C3CCCCO3)cc12.Cc1cc2c(B(O)O)ccnc2[nH]1>>Cc1cc2c(-c3cc(NC(=O)c4ccnn4C(C)C)c4cn[nH]c4c3)ccnc2[nH]1,,CO,O,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20030158178A1,CCCCCC(CO)c1ccc2c(c1)OCCC2(C)C.COC(=O)c1ccc(O)cc1>>CCCCCC(COc1ccc(C(=O)OC)cc1)c1ccc2c(c1)OCCC2(C)C,,C1CCOC1,CCOCC,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030100554A1,CCc1nn(CCOCOCCOC)c(CC)c1Oc1cc(C#N)cc(C#N)c1.NO>>CCc1nn(CCOCOCCOC)c(CC)c1Oc1cc(C#N)cc(C(N)=NO)c1,,CCO,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US09273028B2,Cc1ccc(S(=O)(=O)n2ccc3c(N(CCO)[C@@H]4CCCN(C(=O)OCc5ccccc5)C4)ncnc32)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c(N(CCO)[C@@H]4CCCNC4)ncnc32)cc1,[Pd],CCO,,,,val
US20070093496A1,CCOC=C(C(=O)OCC)C(=O)OCC.CN1CCNCC1=O>>CCOC(=O)c1cn2c(c1O)C(=O)N(C)CC2,,Cc1ccccc1,,C1CCOC1,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20130296302A1,CC(=O)Nc1c(Br)cccc1[N+](=O)[O-].CCCC[Sn](CCCC)(CCCC)c1ccccn1>>CC(=O)Nc1c(-c2ccccn2)cccc1[N+](=O)[O-],c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US04832732,CCCC(C1CCCCC1)n1c(C(=O)OC)cnc1S.O=[N+]([O-])O>>CCCC(C1CCCCC1)n1cncc1C(=O)OC.O=[N+]([O-])O,,O,,[Na+].[OH-],,val
US05519034,COc1ccc(Cl)c(CC#N)c1>>COc1ccc(Cl)c(CCN)c1,,C1CCOC1,,Cl,,val
US20110034433A1,CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(C)(=O)=O)N(C(=O)Oc2ccc([N+](=O)[O-])cc2)C(=O)N1c1cccc(C(F)(F)F)c1.NC1CC1>>CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(C)(=O)=O)N(C(=O)NC2CC2)C(=O)N1c1cccc(C(F)(F)F)c1,,CC#N,,,,val
US20110070192A1,Nc1nc(Cl)c2[nH]cnc2n1.O=S(=O)(O[C@H]1CO[C@@H]2COC(c3ccccc3)O[C@H]2[C@H]1F)C(F)(F)F>>Nc1nc(Cl)c2ncn([C@@H]3CO[C@@H]4COC(c5ccccc5)O[C@H]4[C@H]3F)c2n1,,CN(C)C=O,,[H-].[Na+],,val
US20050267093A1,CCN(CC)CCOc1ccc(N)cc1OC.ClCCl.O=C(O)C#Cc1ccc(C(F)(F)F)cc1Cl>>CCN(CC)CCOc1ccc(NC(=O)C#Cc2ccc(C(F)(F)F)cc2Cl)cc1OC.Cl,,CO,ClCCl,,,val
US20060154926A1,CCCCNC(=O)[C@H](C)C[C@H](O)[C@H](C[C@H](Cc1ccc(OC)c(OCC#N)c1)C(C)C)NC(=O)OC(C)(C)C>>CCCCNC(=O)[C@H](C)C[C@H](O)[C@@H](N)C[C@H](Cc1ccc(OC)c(OCC#N)c1)C(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120302566A1,COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(B5OC(C)(C)C(C)(C)O5)cccc43)ccc21.Cn1ccnc1I>>COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5nccn5C)cccc43)ccc21,,C1COCCO1,Cc1ccccc1,,,val
US06013658,Cc1noc([C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)OC(C)(C)C)n1.Cl>>Cc1noc([C@@H](Cc2ccccc2)NC(=O)[C@H](N)Cc2ccc3ccccc3c2)n1.Cl,,CCOC(C)=O,,,,val
US20160024016A1,CC(C)CCNC(=O)[C@@H]1CC(c2nn(C3CCCCO3)cc2CN(C)CCN(C)C(=O)OC(C)(C)C)CCC1(C)C>>CNCCN(C)Cc1c[nH]nc1C1CCC(C)(C)[C@@H](C(=O)NCCC(C)C)C1,,C1COCCO1,,Cl,,val
US20090088457A1,CC(C)(C)[Si](C)(C)OCCOc1nccs1.CN(C)C=O>>CC(C)(C)[Si](C)(C)OCCOc1ncc(C=O)s1,,C1CCOC1,,O,[Li]CCCC,val
US20100016396A1,CC(=N)NO.COc1ccc(COc2cc(Oc3c(C(=O)O)c(C)nn3C)c(Cl)cc2Cl)cc1>>COc1ccc(COc2cc(Oc3c(-c4nc(C)no4)c(C)nn3C)c(Cl)cc2Cl)cc1,,CN(C)C=O,,O,,val
US20130116247A1,CN(C)C=O.Cc1c(Br)c(=O)oc2cc(O)ccc12.OB(O)O>>O=Cc1c(O)ccc2[nH]c(=O)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20120094968A1,CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(=O)(=O)Cl)NC(=O)N1c1cccc(C(F)(F)F)c1.CN>>CNS(=O)(=O)c1cc(C#N)ccc1[C@H]1NC(=O)N(c2cccc(C(F)(F)F)c2)C(C)=C1C#N,,C1CCOC1,,,,val
US20150112058A1,C=CC[Mg]Br.CC(C)(C)[S@](=O)/N=C/c1nc(Br)c(Br)n1COCC[Si](C)(C)C>>C=CC[C@H](NS(=O)C(C)(C)C)c1nc(Br)c(Br)n1COCC[Si](C)(C)C,,C1CCOC1,,,,val
US20040082607A1,CCCCOc1c(CO)n(CC2CC2)c(=O)c2ccc(OCc3ccccc3)cc12.O=S(Cl)Cl>>CCCCOc1c(CCl)n(CC2CC2)c(=O)c2ccc(OCc3ccccc3)cc12,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US20090098086A1,CC(C)NN.CCOC=C(C#N)C(O)C#N>>CC(C)n1ncc(C#N)c1N,,CCO,,CCN(CC)CC,,val
US20140200216A1,C[C@H]1CNC[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C.Cc1cncc([N+](=O)[O-])c1Cl>>Cc1cncc([N+](=O)[O-])c1N1C[C@H](C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](NC(=O)OC(C)(C)C)C1,,CC(C)O,,CCN(CC)CC,,val
US20140094459A1,CC(C)OB(OC(C)C)OC(C)C.Fc1cc(Oc2ccccc2)ccc1Br>>OB(O)c1ccc(Oc2ccccc2)cc1F,,C1CCOC1,,[Li]CCCC,,val
US20100317645A1,CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(=O)NN)cc32)cc1.CCOC(C)=N>>Cc1nnc(-c2ccc3c(c2)N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)[nH]1,,CC#N,,CCN(CC)CC,Cl,val
US20040198836A1,C1N2CN3CN1CN(C2)C3.COc1ccc(OC)c(C(=O)CBr)c1>>COc1ccc(OC)c(C(=O)CN)c1,,C1CCOC1,O,,,val
US05910506,COc1ccc(COCc2nc(C(C)C)c(Sc3cc(Cl)cc(Cl)c3)n2C)cc1>>CC(C)c1nc(CO)n(C)c1Sc1cc(Cl)cc(Cl)c1,,CCO,,Cl,,val
US20020035102A1,CN=C=S.O=S(=O)(C=C1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1)Cc1cccc(N2CCNCC2)c1>>CNC(=S)N1CCN(c2cccc(CS(=O)(=O)C=C3CN(C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)C3)c2)CC1,,O,,ClCCl,,val
US20150336986A1,CCOC(=O)CCCN.Cn1c(CBr)c(C(=O)c2ccccc2)c(=O)n(C)c1=O>>CCOC(=O)CCCn1cc2c(c1-c1ccccc1)c(=O)n(C)c(=O)n2C,,CCO,,CCN(CC)CC,Cl,val
US20090004185A1,C[C@H](NC(=O)OC(C)(C)C)c1ccc(NC(=O)c2ccc(Cl)nc2)cc1>>C[C@H](N)c1ccc(NC(=O)c2ccc(Cl)nc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110098296A1,CC(=O)N(C)C.Nc1cccc(-c2cnco2)c1.O=C(Cc1ccnc(Cl)n1)c1cccc(NC(=O)c2cc(F)ccc2F)c1>>CN(C(=O)c1cc(F)ccc1F)c1cccc(C(=O)Cc2ccnc(Nc3cccc(-c4cnco4)c3)n2)c1,Cl,O,,CC(C)O,,val
US20080188506A1,CC(C)C1CC(=O)N[C@@H](c2cccc(Cl)c2)[C@@]12C(=O)Nc1cc(Cl)ccc12.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)C1CC(=S)N[C@@H](c2cccc(Cl)c2)[C@@]12C(=O)Nc1cc(Cl)ccc12,,Cc1ccccc1,,,,val
US20050256103A1,C=CCc1c(O)ccc2c1CCCC2=O.CI>>C=CCc1c(OC)ccc2c1CCCC2=O,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20020032208A1,COC(=O)Oc1cc(Nc2ncnc3cc(O)c(OC)cc23)c(F)cc1C.Cl.OCCn1cncn1>>Cc1cc(F)c(Nc2ncnc3cc(OCCn4cncn4)ccc23)cc1O.Cl,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140221345A1,O=[N+]([O-])c1cccc(S(=O)(=O)OC[C@H]2CO2)c1.c1ccc2c(c1)CCNC2>>c1ccc2c(c1)CCN(C[C@H]1CO1)C2,,C1CCOC1,,[F-].[K+],,val
US20150031715A1,CC(C)(C)OC(=O)NCCCBr.COC(=O)[C@H](Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1)NC(=O)c1c(Cl)cc(O)cc1Cl>>COC(=O)[C@H](Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1)NC(=O)c1c(Cl)cc(OCCCNC(=O)OC(C)(C)C)cc1Cl,,CC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20150141406A1,CC1(C)OB(c2ccc(S(N)(=O)=O)cc2)OC1(C)C.COc1ccc(Cn2nc(OS(=O)(=O)C(F)(F)F)c3c(OC)nccc32)cc1>>COc1ccc(Cn2nc(-c3ccc(S(N)(=O)=O)cc3)c3c(OC)nccc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20110269956A1,CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1ncc(-c2ccc(Br)cc2)[nH]1.CC1(C)OB(c2ccc3cc(B4OC(C)(C)C(C)(C)O4)ccc3c2)OC1(C)C>>CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1ncc(-c2ccc(-c3ccc4cc(B5OC(C)(C)C(C)(C)O5)ccc4c3)cc2)[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20140349990A1,Cn1cc(C(Nc2cc(Cl)c(=O)n(C)c2)c2ccc(Cl)cc2)c(C(=O)O)n1>>Cn1cc2c(n1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1,,CO,ClCCl,,,val
US20050176775A1,Cc1cc(O)c(Br)c(=O)n1Cc1cccc(F)c1.Cc1cc(O)cc(=O)n1Cc1cccc(F)c1.ClCCl>>Cc1cc(CCc2ccccc2)c(Br)c(=O)n1Cc1cccc(F)c1,,ClCCl,,O=C1CCC(=O)N1Br,,val
US20060217372A1,CC(C)(C)CCCN.NC(=O)c1cnc(Oc2ccc(C=O)cc2F)cn1>>CC(C)(C)CCCNCc1ccc(Oc2cnc(C(N)=O)cn2)c(F)c1,,CO,,[BH4-].[Na+],,val
US20150087646A1,N.O=C(O)c1ccc(Cl)cc1F>>NC(=O)c1ccc(Cl)cc1F,,C1CCOC1,,O=C(Cl)C(=O)Cl,,val
US20090215783A1,CC(C)(C)OC(=O)CBr.CN(N)C(=O)NCc1ccccc1>>CNN(C(=O)NCc1ccccc1)C(C(=O)O)C(C)(C)C,,Cc1ccccc1,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06358971B1,O=C(c1ccccc1)c1ccc2nc(NC(=O)C(F)(F)F)c(-c3ccc(Cl)c(Cl)c3)n2c1>>Nc1nc2ccc(C(=O)c3ccccc3)cn2c1-c1ccc(Cl)c(Cl)c1,,CCOC(C)=O,,,,val
US04346088,Br.CN1C(=Nc2ccccc2)SCC1(O)c1ccc(Cl)c(S(=O)(=O)N(C)C)c1>>Br.CN(C)S(=O)(=O)c1cc(-c2csc(=Nc3ccccc3)n2C)ccc1Cl,,CC(=O)O,,,,val
US20100069394A1,CC(C)(C)OC(=O)N1CCN(c2ccc(C(F)(F)F)nn2)CC1.II>>CC(C)(C)OC(=O)N1CCN(c2cc(I)c(C(F)(F)F)nn2)CC1,,C1CCOC1,CC(=O)O,CC1(C)CCCC(C)(C)N1,[Li]CCCC,val
US20100239496A1,C#Cc1ccc(NC)c(F)c1.COc1ccc2nc(I)sc2c1>>CNc1ccc(C#Cc2nc3ccc(OC)cc3s2)cc1F,[Cu]I,CC#N,,,,val
US20040122001A1,CS(=O)(=O)OCCC1OCCc2cc(Br)ccc21.Fc1ccc2c(C3=CCNCC3)c[nH]c2c1>>Fc1ccc2c(C3=CCN(CCC4OCCc5cc(Br)ccc54)CC3)c[nH]c2c1,,CC#N,O,[I-].[K+],,val
US05498777,CC(=O)OO.Cc1ccc([N+](=O)[O-])c(Cl)n1>>Cc1ccc([N+](=O)[O-])c(Cl)[n+]1[O-],,CC(=O)O,,O=C(O)C(F)(F)F,,val
US20040048897A1,CN1CCCN(S(=O)(=O)c2c(Cl)ccc(N)c2O)CC1.O=c1c(Cl)c(Cl)c1=O>>CN1CCCN(S(=O)(=O)c2c(Cl)ccc(Nc3c(Cl)c(=O)c3=O)c2O)CC1,,C1CCOC1,,,,val
US20030207888A1,CC(=O)CCCCl.C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(Br)nc3N21>>C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(C(C)(O)CCCCl)nc3N21,,CCOCC,,[Li]C(C)(C)C,,val
US20150225367A1,CC(C)(C)OC(=O)n1cc(-c2ccc(S(N)(=O)=O)nc2)c2ccc(F)cc21.Cl>>Cl.NS(=O)(=O)c1ccc(-c2c[nH]c3cc(F)ccc23)cn1,,CCOC(C)=O,,,,val
US20100234389A1,CC(C)(C)OC(=O)N1CCN(c2cc(Cl)ncn2)CC1.OB(O)c1ccc(F)cc1>>CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccc(F)cc3)ncn2)CC1,,O,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20060106013A1,O=C(Cl)[C@@H]1CCCO1.c1c[nH]cn1>>O=C([C@@H]1CCCO1)n1ccnc1,,ClC(Cl)Cl,,,,val
US20160075711A1,O=[N+]([O-])c1ccc(OC2(S(=O)(=O)c3ccccc3)CC2)nc1Cl>>Nc1ccc(OC2(S(=O)(=O)c3ccccc3)CC2)nc1Cl,[Pd],CCOC(C)=O,CO,N#N,,val
US20110305776A1,COC(=O)c1ccccc1S.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>COC(=O)c1ccccc1SC(c1ccccc1)(c1ccccc1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20040220241A1,CCCC(Oc1cccc(C(=N)NO)c1)C(=O)Nc1ccc(-c2ccccc2S(C)(=O)=O)cc1.Cl>>CCCC(Oc1cccc(C(=N)NO)c1)C(=O)Nc1ccc(-c2ccccc2S(C)(=O)=O)cc1.Cl,,CC(C)O,CO,,,val
US20030027809A1,CCCC[Sn](Cl)(CCCC)CCCC.[N-]=[N+]=NCCCCCCSc1ncn2ccsc12>>CCCC[Sn](CCCC)(CCCC)c1cn2cnc(SCCCCCCN=[N+]=[N-])c2s1,,C1CCOC1,,[Cl-].[NH4+],C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US04013664,COc1cc2c(cc1O)C(Cc1cc(Br)c(OC)cc1[N+](=O)[O-])N(C)CC2>>Br.COc1ccc(CC2c3cc(O)c(OC)cc3CCN2C)c(N)c1,[Pd],CO,,,,val
US20040106063A1,CC(=O)Cl.CC(=O)OCC(=O)Cl.CCN(CC)CC.O.OCCN(CCO)CCO>>CC(=O)OCCN(CCOC(C)=O)CCOC(=O)COC(C)=O,,O,,C1CCOC1,,val
US05124331,CCN1CCNCC1.O=c1c2c3c(sc2nc(CCl)n1-c1ccccc1Cl)CCCC3>>CCN1CCN(Cc2nc3sc4c(c3c(=O)n2-c2ccccc2Cl)CCCC4)CC1,,ClC(Cl)Cl,,O=C([O-])[O-].[K+].[K+],,val
US20160083368A1,CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)c1nc(C#CC2(O)CCOCC2)ccc1Br.Cc1c(B2OC(C)(C)C(C)(C)O2)ccc2n[nH]c(=O)n12>>Cc1c(-c2ccc(C#CC3(O)CCOCC3)nc2[C@H](Cc2cc(F)cc(F)c2)NC(=O)OC(C)(C)C)ccc2n[nH]c(=O)n12,,O,,C1COCCO1,O=C([O-])O.[Na+],val
US20100135999A1,CCCCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(O)c3ccc(C)cc3c2)CC1.O=C(CBr)OCc1ccccc1>>CCCCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)OCc3ccccc3)c3ccc(C)cc3c2)CC1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110021489A1,CCOc1noc(C2CNCC(c3ccc(OC(F)(F)F)c(F)c3)C2)n1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CCOc1noc(C2CC(c3ccc(OC(F)(F)F)c(F)c3)CN(C(=O)Oc3ccc([N+](=O)[O-])cc3)C2)n1,,ClCCl,,CCN(CC)CC,O,val
US20070010539A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)N1CCC(N)(CC#N)CC1>>CCOC(=O)N1CCC(CC#N)(NC(=O)OC(C)(C)C)CC1,,C1CCOC1,,CCN(CC)CC,O,val
US20090156607A1,CCCC1CC(=O)N(Cc2c[nH]c3ncccc23)C1.O=C(OO)c1cccc(Cl)c1>>CCCC1CC(=O)N(Cc2c[nH]c3c2ccc[n+]3[O-])C1,,COCCOC,,CCCCCC,,val
US20110263582A1,C=CC[C@@](N)(CCN[C@@H](C)C(C)(C)C)c1ccc(F)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>C=CC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)C(C)(C)C)C(=O)N1,,ClCCl,,CCN(CC)CC,,val
US05047411,CCOc1ccn2c(C)c(C=Cc3ccc([N+](=O)[O-])c(OCc4ccccc4)c3)nc2c1>>CCOc1ccn2c(C)c(CCc3ccc(N)c(O)c3)nc2c1,[Pd],CN(C)C=O,,[H][H],,val
US20100234370A1,COC(=O)C1CN(C(=O)OC(C)(C)C)CCN1S(C)(=O)=O>>CS(=O)(=O)N1CCN(C(=O)O)CC1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20100216814A1,CC(=CBr)c1ccncc1.Cc1ccc2[nH]c3c(c2c1)CN(C(C)C)CC3>>C/C(=C\n1c2c(c3cc(C)ccc31)CN(C(C)C)CC2)c1ccncc1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20080090854A1,COC(=O)C(C)(C)NC(=O)c1ccc2ccccc2c1OCc1ccc(Br)cc1>>CC(C)(NC(=O)c1ccc2ccccc2c1OCc1ccc(Br)cc1)C(=O)O,,C1CCOC1,,[Na+].[OH-],,val
US20100273764A1,Cc1cnc(F)c(Br)c1.O=C1CCC(=O)N1Br>>Fc1ncc(CBr)cc1Br,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US20050245741A1,COc1ccc(COc2ccc(C(=O)NC3CC3)c(O)c2)cc1.C[C@@]1(COS(=O)(=O)c2cccc([N+](=O)[O-])c2)CO1>>COc1ccc(COc2ccc(C(=O)NC3CC3)c(OC[C@]3(C)CO3)c2)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110275608A1,O=Cc1cc(-c2ccccc2)no1.OCC1CCNCC1>>OCC1CCN(Cc2cc(-c3ccccc3)no2)CC1,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05565485,CCCc1cc(CO)cc(CCC)c1O[Si](C)(C)C(C)(C)C>>CCCc1cc(C=O)cc(CCC)c1O[Si](C)(C)C(C)(C)C,,CCOCC,ClCCl,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20150126449A1,Cc1ccc2c(n1)nn1c(=O)cc(C3CCN(C(=O)OC(C)(C)C)CC3)[nH]c21.Cl>>Cc1ccc2c(n1)nn1c(C3CCNCC3)cc(=O)[nH]c21.Cl,,C1COCCO1,CO,,,val
US20110118231A1,CC(C)(C)OC(=O)N1C[C@H]2CNCc3cccnc3[C@@H]2C1.O=S(=O)(Cl)c1ccc(Cl)c(Cl)c1>>CC(C)(C)OC(=O)N1C[C@H]2CN(S(=O)(=O)c3ccc(Cl)c(Cl)c3)Cc3cccnc3[C@@H]2C1,,ClCCl,,CCN(CC)CC,[Na+].[OH-],val
US20040254178A1,Cc1c(C2CCN(C(=O)OCc3ccccc3)CC2)nnc(-c2cccc(C(F)(F)F)c2)c1-c1ccnc(NC(C)c2ccccc2)n1>>Cc1c(C2CCNCC2)nnc(-c2cccc(C(F)(F)F)c2)c1-c1ccnc(NC(C)c2ccccc2)n1,[Pd],CCO,,,,val
US20120077987A1,Brc1ccc(-c2ccc3c(c2)c2ccccc2n3-c2ccccc2)cc1.CCCCCC.CCOC(C)=O>>c1ccc(-n2c3ccccc3c3cc(-c4ccc(-c5cccc6ccccc56)cc4)ccc32)cc1,,CCCCCC,,,,val
US20110003798A1,COC(=O)c1c(C#CCCCN2C(=O)c3ccccc3C2=O)ccnc1OC.N>>COc1nccc2cc(CCCN3C(=O)c4ccccc4C3=O)[nH]c(=O)c12,,CO,,,,val
US20080242706A1,Cc1c(OCc2ccccc2)c(=O)c(C(O)C(F)(F)F)cn1C>>Cc1c(O)c(=O)c(C(O)C(F)(F)F)cn1C,[Pd],CO,,,,val
US20050113566A1,Nc1ccccc1Br.OB(O)C1=CCCCC1>>Nc1ccccc1C1=CCCCC1,,CCO,CCOC(C)=O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20020055508A1,C1CCNCC1.O=C(O)c1ccc(Cl)c([N+](=O)[O-])c1>>O=C(c1ccc(Cl)c([N+](=O)[O-])c1)N1CCCCC1,,CCOC(C)=O,,O=C(c1ncc[nH]1)c1ncc[nH]1,,val
US06083961,CN(C(=O)CN1C(=O)c2ccccc2C1=O)c1ccc(Cl)c(COS(C)(=O)=O)c1Cl.Cc1nc2c(O)cccc2n1C>>Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CN4C(=O)c5ccccc5C4=O)c3Cl)cccc2n1C,,CN(C)C=O,,O,[H-].[Na+],val
US20040073037A1,CCCCC(=O)Cl.NCC1CCC(CN(Cc2ccccc2)S(=O)(=O)NC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1>>CCCCC(=O)NCC1CCC(CN(Cc2ccccc2)S(=O)(=O)NC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1,,ClCCl,,CCN(CC)CC,,val
US05854179,CC(C)(C)NS(=O)(=O)c1cc([N+](=O)[O-])ccc1Cl.CCS>>CCSc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060229312A1,CO.C[Si](C)(C)Cl.Nc1cccc(CC(=O)O)c1>>COC(=O)Cc1cccc(N)c1.Cl,,CO,,,,val
US20100261755A1,CCOC(=O)CC(=O)[C@H]1CCN(C(=O)OC)[C@@H](c2cc(F)c(F)c(F)c2)C1.NO>>COC(=O)N1CC[C@H](c2cc(=O)[nH]o2)C[C@@H]1c1cc(F)c(F)c(F)c1,,CO,,Cl,[Na+].[OH-],val
US05556863,CCCC(=O)c1cnc2c(OCCSC)cccc2c1Cl.Cc1cc(O)ccc1N>>CCCC(=O)c1cnc2c(OCCSC)cccc2c1Nc1ccc(O)cc1C,,CC#N,,,,val
US20150038488A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN1CCN(C(=O)OC(C)(C)C)c2cc(Br)ccc21>>CN1CCN(C(=O)OC(C)(C)C)c2cc(B3OC(C)(C)C(C)(C)O3)ccc21,,C1COCCO1,,ClCCl,CC(=O)[O-].[K+],val
US05235063,CC1(CCCc2ccc(N)cc2)OCCO1.OCC1CO1>>CC1(CCCc2ccc(NCC(O)CO)cc2)OCCO1,,CCO,,,,val
US20140080806A1,Cn1ncc(C(O)c2c(Cl)ncnc2Cl)c1Br>>Cn1ncc(C(=O)c2c(Cl)ncnc2Cl)c1Br,,ClC(Cl)Cl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20070197617A1,CC(C)(C)OC(=O)N[C@@H](C(=O)O)c1ccc(OC(COCc2ccccc2)COCc2ccccc2)cc1>>CC(C)(C)OC(=O)N[C@@H](C(=O)O)c1ccc(OC(CO)CO)cc1,,CO,,,,val
US03974286,Cc1cccc2sc(=N)n(N)c12.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1cccc2sc(=NC(=O)C(F)(F)F)n(N)c12,,CCN(CC)CC,,C1CCOC1,,val
US20030191160A1,CCOC(C)=O.COC(=O)c1cccc2c1nc(-c1c(F)cccc1F)n2Cc1c(F)cccc1F.[Li]C>>CC(O)CC(=O)c1cccc2c1nc(-c1c(F)cccc1F)n2Cc1c(F)cccc1F,,CCOC(C)=O,,C1CCOC1,,val
US04713387,CCOC(=O)CP(=O)(OCC)OCC.O=Cc1ccc(Oc2cccnc2)cc1>>CCOC(=O)/C=C/c1ccc(Oc2cccnc2)cc1,,C1CCOC1,,O,[H-].[Na+],val
US20020160996A1,Cc1c(C)c2c(c(C)c1N)C(c1ccc(F)cc1)C(C)(C)O2.O=C(Cl)c1ccc(F)cc1>>Cc1c(C)c2c(c(C)c1NC(=O)c1ccc(F)cc1)C(c1ccc(F)cc1)C(C)(C)O2,,CCCCCC,CCOC(C)=O,,,val
US20040180922A1,COC(=O)COc1cc(C)c2c(N)c(C(N)=O)sc2n1.Nc1ccc([N+](=O)[O-])cc1>>NC(=O)c1sc2nccc(Nc3ccc([N+](=O)[O-])cc3)c2c1N,,C1COCCO1,,,,val
US20150031106A1,Brc1cccc2c[nH]cc12.COC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C.O=C(c1ncc[nH]1)c1ncc[nH]1>>COC(=O)C1CC(OC(=O)N2Cc3cccc(Br)c3C2)CN1C(=O)OC(C)(C)C,,CC(=O)N(C)C,,,,val
US20150065482A1,COC(=O)c1nn(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)c2ccc(C#N)cc12.N>>CN1CC[C@@](O)(C#Cc2cccc(-n3nc(C(N)=O)c4cc(C#N)ccc43)c2)C1=O,,CO,,,,val
US20120232051A1,CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1Br.Cc1ccc(F)c(B(O)O)c1>>Cc1ccc(F)c(-c2ccncc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1,,CN(C)C=O,,,,val
US20100022583A1,C=C(C)CBr.COC(=O)Cc1cc(-c2ccc(F)cc2)nc(-c2ccc(C(F)(F)F)cc2)c1>>C=C(C)CC(C(=O)OC)c1cc(-c2ccc(F)cc2)nc(-c2ccc(C(F)(F)F)cc2)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20120122843A1,C[N+](=O)[O-].O=CC1CCCO1>>O=[N+]([O-])CC(O)C1CCCO1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20050288314A1,O=C(O)C(O)c1ccc(F)cc1>>OCC(O)c1ccc(F)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110144105A1,CS(=O)(=O)c1ccc(C(=CC2CCCC2)c2cc3cc(C(=O)O)cnc3[nH]2)cc1>>CS(=O)(=O)c1ccc(C(CC2CCCC2)c2cc3cc(C(=O)O)cnc3[nH]2)cc1,[Pd],CO,,[H][H],,val
US20130274483A1,O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2[C@@]1(COCc1ccccc1)c1cc2c(cc1OCc1ccccc1)OCO2>>O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2[C@@]1(CO)c1cc2c(cc1O)OCO2,[Pd],,,CC(=O)O,,val
US20060079526A1,COc1ccc(C(=O)Cl)cc1C(F)(F)F.Nc1nnc(-c2ccc(Oc3cccnc3)cc2)o1>>COc1ccc(C(=O)Nc2nnc(-c3ccc(Oc4cccnc4)cc3)o2)cc1C(F)(F)F,,CO,c1ccncc1,Br,,val
US04717418,CCCC(=O)Cl.Cc1cc(C)c(C2CC(=O)C=C(O)C2)c(C)c1>>CCCC(=O)C1=C(O)CC(c2c(C)cc(C)cc2C)CC1=O,,O,,ClCCl,c1ccncc1,val
US20090029947A1,N[C@]1(CO)CC[C@@H](c2ccc(OCCc3ccc(OCc4ccccc4)cc3)cc2)C1>>N[C@]1(CO)CC[C@@H](c2ccc(OCCc3ccc(O)cc3)cc2)C1,[Pd],CCO,,,,val
US20100184741A1,O=C(CCl)Nc1ccccc1CO>>O=C1COCc2ccccc2N1,,CC(C)O,,[Na+].[OH-],,val
US20110257148A1,CC(C)N.OC(CCl)(CCl)c1cc(F)cc(Cl)c1>>CC(C)N1CC(O)(c2cc(F)cc(Cl)c2)C1,,CC#N,,O=C([O-])O.[Na+],,val
US20100062937A1,Cc1cc(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)ccc1[N+](=O)[O-]>>Cc1cc(C(O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)ccc1[N+](=O)[O-],,CCOC(C)=O,CO,[BH4-].[Na+],,val
US20070219183A1,CC(=O)OC(C)=O.NCC(=O)N1CC=C(c2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)n2nccc21>>CC(=O)NCC(=O)N1CC=C(c2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)n2nccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US04873255,Cc1c(C)c(C)c2c(c1C)C=CC(C)(COc1ccc([N+](=O)[O-])cc1)O2>>Cc1c(C)c(C)c2c(c1C)CCC(C)(COc1ccc(N)cc1)O2,[Pd],c1ccccc1,,CO,,val
US20080027068A1,CCCCCc1ccc(-c2c(O)c(C(C)=O)nn2C)cc1.NNC(=S)Nc1ccc(C(=O)O)cc1>>CCCCCc1ccc(-c2c(O)c(C(C)=NNC(=S)Nc3ccc(C(=O)O)cc3)nn2C)cc1,Cl,O,,CN(C)C=O,,val
US20010056100A1,COC(=O)[C@@H](Cc1ccccc1)N=C=O.OCc1cc2cc(-c3ccsc3)ccc2o1>>COC(=O)[C@@H](Cc1ccccc1)NC(=O)OCc1cc2cc(-c3ccsc3)ccc2o1,,C1CCOC1,,CCN(CC)CC,,val
US20070249670A1,C=CCc1cc(C)c(NC(=O)Nc2cc(Cl)cnc2C(=O)NC2(C(=O)OC)CCCCCCC2)c(C)c1>>CCCc1cc(C)c(NC(=O)Nc2cc(Cl)cnc2C(=O)NC2(C(=O)OC)CCCCCCC2)c(C)c1,[Pd],CCOC(C)=O,,,,val
US20120010190A1,CC(C)[C@@H](N)CO.Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)O)cc1>>Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)N[C@@H](CO)C(C)C)cc1,,C1CCOC1,,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,,val
US20100010021A1,C=CCn1cnc2c1c(=O)n(C)c(=O)n2CCCCC.CN(C)C=O>>CCCCCn1c(=O)n(C)c(=O)c2[nH]c(C#N)nc21,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20110003787A1,COC[C@@H](C)O.COc1cc(O)cc(Br)c1>>COC[C@H](C)Oc1cc(Br)cc(OC)c1,,Cc1ccccc1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05308857,COC(=O)NC(=N)SC.NCc1ccc(-c2csc(N=C(N)N)n2)o1>>COC(=O)N=C(N)NCc1ccc(-c2csc(N=C(N)N)n2)o1,,CCN(CC)CC,,,,val
US20040102436A1,CCOC(=O)C=CC1CCCN1C(=O)OCc1ccccc1>>O=C(OCc1ccccc1)N1CCCC1C=CCO,,Cl,,CC(C)C[Al+]CC(C)C.[H-],,val
US20110274648A1,CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1nc(C#Cc2ccc3cc(-c4c[nH]c([C@@H]5C[C@H]6C[C@H]6N5C(=O)OC(C)(C)C)n4)ccc3c2)c[nH]1.Cl>>C(#Cc1c[nH]c([C@@H]2C[C@H]3C[C@H]3N2)n1)c1ccc2cc(-c3cnc([C@@H]4C[C@H]5C[C@H]5N4)[nH]3)ccc2c1.Cl,,C1COCCO1,,,,val
US20120163145A1,C#Cc1cc(OC)cc(OC)c1.C[Si](C)(C)C#Cc1ccc(I)cc1>>COc1cc(C#Cc2ccc(C#C[Si](C)(C)C)cc2)cc(OC)c1,[Cu]I,C1CCOC1,CCN(CC)CC,,,val
US20020161041A1,COC(=O)C[C@H]1CC[C@@H](c2ccc(O)cc2O)CC1>>O=C(O)C[C@H]1CC[C@@H](c2ccc(O)cc2O)CC1,,CCOC(C)=O,O,Cl,[Na+].[OH-],val
US05580883,CC(C)(C)OC(=O)Nc1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1.CC(C)=CCBr>>CC(C)=CCN(C(=O)OC(C)(C)C)c1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1,,CC(C)=O,,O,[K+].[OH-],val
US20150191495A1,CCOC(=O)C1C2Cc3cc(O)ncc3C21.Cc1cccc(C)c1-c1ccc(F)c(CBr)n1>>CCOC(=O)C1C2Cc3cc(OCc4nc(-c5c(C)cccc5C)ccc4F)ncc3C21,,Cc1ccccc1,,,,val
US06875759B1,C1CNCCN1.Cc1ccc(N=C=Nc2ccc(C)cc2)cc1>>Cc1ccc(N=C(Nc2ccc(C)cc2)N2CCNCC2)cc1,,CN(C)C=O,,,,val
US20050054626A1,CC(C)S(=O)(=O)C[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1NC(=O)OCc1ccccc1>>CC(C)S(=O)(=O)C[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N,[Pd],CO,,,,val
US20160002273A1,CO.Cc1nc(Cl)c2sccc2n1>>COc1nc(C)nc2ccsc12,,CO,,C[O-].[Na+],,val
US20060030613A1,CC(C)(C)c1ccc(CNCCc2ccc(Cl)cc2Cl)cc1.O=C(O)c1cccc2cc[nH]c12>>CC(C)(C)c1ccc(CN(CCc2ccc(Cl)cc2Cl)C(=O)c2cccc3cc[nH]c23)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20020007071A1,BrCCCc1ccccc1.COc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCNCC1>>COc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCc2ccccc2)CC1,,CN(C)C=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20160272662A1,CC(C)(C)CO.O=C=NS(=O)(=O)Cl>>CC(C)(C)COS(N)(=O)=O,,ClCCl,,CCN(CC)CC,O=CO,val
US20080312192A1,CNC(=O)c1cc(NC(=O)Nc2ccc(Oc3cc(N=[N+]=[N-])ncn3)cc2)cc(C(F)(F)F)c1>>CNC(=O)c1cc(NC(=O)Nc2ccc(Oc3cc(N)ncn3)cc2)cc(C(F)(F)F)c1,[Pd],COCCOC,,,,val
US20050176775A1,CCOC(=O)c1cc(COS(C)(=O)=O)nn1C1CCCCO1.Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)[nH]1>>CCOC(=O)c1cc(Cn2c(C)cc(OCc3ccc(F)cc3F)c(Br)c2=O)nn1C1CCCCO1,,C1CCOC1,,[H-].[Na+],,val
US20020099208A1,Nc1ccccc1S(=O)(=O)NC1CC1.O=C(n1ccnc1)n1ccnc1>>O=C1Nc2ccccc2S(=O)(=O)N1C1CC1,,ClCCl,,,,val
US20100016321A1,CCCCNS(=O)(=O)Cc1cccc(Cl)c1.CCOC(=O)C(=O)OCC>>CCCCN1C(=O)C(O)=C(c2cccc(Cl)c2)S1(=O)=O,,C1CCOC1,,Cl,CC(C)(C)[O-].[K+],val
US20090298815A1,NC(=S)N1CCCC1.O=S(=O)(Nc1cccc(/C(O)=C/c2ccnc(Cl)n2)c1)c1c(F)cccc1F>>O=S(=O)(Nc1cccc(-c2nc(N3CCCC3)sc2-c2ccnc(Cl)n2)c1)c1c(F)cccc1F,,ClCCl,,O=C1CCC(=O)N1Br,,val
US20050107388A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)NCCc1cc2c(N)cccc2cn1>>CC(C)(C)OC(=O)NCCc1cc2c(N)cccc2cn1,,CCO,,[K+].[OH-],,val
US20120129806A1,C=CCO.COC(=O)C1CCCC1=O>>C=CCOC(=O)C1CCCC1=O,[Zn],Cc1ccccc1,,,,val
US20050059650A1,CS(=O)(=O)c1ccc(-n2ncc3c(SC4CCNCC4)ncnc32)c(F)c1.O=C(n1ccnc1)n1ccnc1.OCCC1CC1>>CS(=O)(=O)c1ccc(-n2ncc3c(SC4CCN(C(=O)OCCC5CC5)CC4)ncnc32)c(F)c1,,CS(C)=O,,CCN(CC)CC,Cl,val
US20100075995A1,Nc1nc(OC2CCCCC2)nc2c1ncn2C1CCCCO1.O=C1CCC(=O)N1Br>>Nc1nc(OC2CCCCC2)nc2c1nc(Br)n2C1CCCCO1,,ClC(Cl)Cl,,O,,val
US06143764,CCOC(=O)c1cccc(N=C=O)c1.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC>>CCOC(=O)c1cccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)c1,,Cc1ccccc1,,,,val
US20080275038A1,Nc1nc(-c2ccncc2)c(-c2ccncc2)cc1[N+](=O)[O-]>>Nc1cc(-c2ccncc2)c(-c2ccncc2)nc1N,[Fe],CCO,Cl,,,val
US20090137548A1,COc1ccc(C2(O)CCN(Cc3ccccc3)CC2)c(F)c1>>COc1ccc(C2=CCN(Cc3ccccc3)CC2)c(F)c1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US04374829,CCOC(=O)C(=O)CCc1cccs1.C[C@H](N)C(=O)N1CCC[C@H]1C(=O)O>>CCOC(=O)C(CCc1cccs1)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O,,CCO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20100261679A1,CCCCOC(=O)c1cc(Oc2ccc3nc(Nc4ccccc4N4CCOCC4)ncc3c2)ccn1>>O=C(O)c1cc(Oc2ccc3nc(Nc4ccccc4N4CCOCC4)ncc3c2)ccn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120264738A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C(=O)O)OC1.CO.Cl>>COC(=O)[C@@H]1CC[C@@H](N)CO1.Cl,,CO,,C1COCCO1,,val
US20040049039A1,COC(OC)N(C)C.Cc1nc2ccccc2c(=O)n1-c1ccccc1Cl>>CN(C)C=Cc1nc2ccccc2c(=O)n1-c1ccccc1Cl,,CN(C)C=O,,,,val
US20030105151A1,COc1cccc(-c2ccc3c(c2)NC(=O)C3)c1.Cc1[nH]c(C=O)c(C)c1CCC(=O)O>>COc1cccc(-c2ccc3c(c2)NC(=O)C3=Cc2[nH]c(C)c(CCC(=O)O)c2C)c1,C1CCNCC1,CCO,,,,val
US20140349998A1,C=C(C)C(=O)Cl.C[Si](C)(C)CCOCn1cc(C2CCCO2)c2c(-c3cccc(N)c3)ncnc21>>C=C(C)C(=O)Nc1cccc(-c2ncnc3c2c(C2CCCO2)cn3COCC[Si](C)(C)C)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20060166997A1,CC(C)S(=O)(=O)c1ccc([N+](=O)[O-])cc1-c1cccn1C(=O)OC(C)(C)C.Cl>>CC(C)S(=O)(=O)c1ccc(N)cc1C1CCCN1.Cl,O=[Pt],CCO,,,,val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2cc(OC)c(OC)cc23)cc1.Nc1cc(C2CC2)[nH]n1>>COc1cc2nc(Nc3cc(C4CC4)[nH]n3)c3n[nH]cc3c2cc1OC,C1COCCO1,CO,,Cl,,val
US20080027067A1,Nc1nccs1.O=C(Nc1ccc(S(=O)(=O)Cl)cc1F)C(F)(F)F>>O=C(Nc1ccc(S(=O)(=O)Nc2nccs2)cc1F)C(F)(F)F,,c1ccncc1,,,,val
US20060264415A1,COc1cc([N+](=O)[O-])ccc1OCCN(C)C>>COc1cc(N)ccc1OCCN(C)C,[Pd],CO,,,,val
US04533498,C1=CC2CCC1CN2.O=C(Cl)c1ccccc1>>O=C(c1ccccc1)N1CC2C=CC1CC2,,[Na+],[OH-],,,val
US20160145247A1,CC(C)(C)OC(=O)N[C@H](CO)c1cccc(-c2cccc(COc3ccccc3CC(=O)O)c2)c1.Cl>>Cl.N[C@H](CO)c1cccc(-c2cccc(COc3ccccc3CC(=O)O)c2)c1,,CCOCC,,ClCCl,,val
US05260488,NC1=CC([N+](=O)[O-])C(N)(CC(F)(F)F)C=C1.O=C(Cl)OCCCl>>O=C(Nc1ccc(CC(F)(F)F)c([N+](=O)[O-])c1)OCCCl,,C1COCCO1,,CCCCCC,,val
US20080064682A1,CC(=O)c1cnn(C)c1.CCOC(=O)C(=O)OCC>>CCOC(=O)C(=O)CC(=O)c1cnn(C)c1,,CCO,,C,C[O-].[Na+],val
US20050165065A1,CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)O.CCO>>CCOC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20150057273A1,CC(C)(C)SC1CC(=O)c2ccccc21>>CC(C)(C)S[C@H]1C[C@@H](O)c2ccccc21,,CO,,[BH4-].[Na+],,val
US20130079320A1,CCOC(=O)Cc1ccc(C=N)cc1.CI>>CCOC(=O)C(C)c1ccc(C#N)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20040058965A1,COC(=O)Cc1cccc(OCc2cccc(OCc3nc(-c4ccccc4)oc3C)n2)c1>>Cc1oc(-c2ccccc2)nc1COc1cccc(COc2cccc(CC(=O)O)c2)n1,,CO,,C1CCOC1,[Na+].[OH-],val
US20080242677A1,Cc1ccc(C)c(N2CCN(C(=O)[C@@H]3CN(S(=O)(=O)CC4CCCCC4)C(=O)N3)CC2)c1.OB(O)c1ccccc1>>Cc1ccc(C)c(N2CCN(C(=O)[C@@H]3CN(S(=O)(=O)CC4CCCCC4)C(=O)N3c3ccccc3)CC2)c1,,ClCCl,,CCN(CC)CC,,val
US04219551,O=C1CC(c2cccc(OCC(O)CN3CCN(c4ccccc4)CC3)c2)CN1>>O=C1CC(c2cccc(OCC3CO3)c2)CN1.c1ccc(N2CCNCC2)cc1,,CO,ClC(Cl)Cl,CCOCC,,val
US04044141,CCO.COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)c2ccc(Cl)cc2)C1c1ccccc1[N+](=O)[O-]>>C/C(N)=C/C(=O)OC(C)c1ccc(Cl)cc1.COC(=O)CC(=O)/C=C/c1ccccc1[N+](=O)[O-],,CCO,,,,val
US04352808,OC1c2ccc(Cl)cc2SCC1Br.c1c[nH]cn1>>O[C@H]1c2ccc(Cl)cc2S[C@H]1Cc1ncc[nH]1,,O,,CC#N,,val
US20070287737A1,NN.O=C(O)c1c(Nc2ccc(I)cc2F)cncc1-c1ccccc1Cl>>NNC(=O)c1c(Nc2ccc(I)cc2F)cncc1-c1ccccc1Cl,,CS(C)=O,,O,O=C(n1ccnc1)n1ccnc1,val
US20090253687A1,CC(=O)OCC(=O)CCl.NC1=NC=C(c2ccc3c(c2)NC(=O)CO3)C(c2ccccc2)S1>>CC(=O)OCc1cn2c(n1)SC(c1ccccc1)C(c1ccc3c(c1)NC(=O)CO3)=C2,,COCCOC,,CCOC(C)=O,O=C([O-])O.[Na+],val
US04914112,CC(c1cccc(C(=O)c2ccccc2)c1)c1nc(N(C)C)no1>>CC(c1cccc(C(O)c2ccccc2)c1)c1nc(N(C)C)no1,,CO,,Cl,[Na],val
US20050203159A1,NCC(=O)c1ccc(F)cc1.S=C=Nc1ccc(Cl)cc1>>Fc1ccc(-c2cnc(S)n2-c2ccc(Cl)cc2)cc1,,CCO,,Cl,O=C([O-])O.[Na+],val
US07265245B2,O=C(O)c1cc(-c2ccc(F)cc2F)ccc1O.[I-]>>O=C(O)c1cc(-c2ccc(F)cc2F)cc(I)c1O,,CC#N,,CC(=O)O,,val
US20040204408A1,COc1ccccc1C(=O)[O-].NC1CC1>>O=C(NC1CC1)c1ccccc1O,,Cc1ccccc1,,,,val
US20150361067A1,Cc1ccc(Cl)cc1CCN.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>Cc1ccc(Cl)cc1CCNC(=O)Oc1ccc([N+](=O)[O-])cc1,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20110021515A1,CCOC(=O)C1OCC(C)(C)C1=O.N=C(N)c1ccc(Br)cc1>>CC1(C)COc2c(O)nc(-c3ccc(Br)cc3)nc21,,CCOC(C)=O,CO,Cl,C[O-].[Na+],val
US20110071128A1,CC(C)(C)OC(=O)Nc1cc2nc(-c3ccccc3)cn2cc1Br>>Nc1cc2nc(-c3ccccc3)cn2cc1Br,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080306082A1,CN1CCN(CCCN)CC1.COc1ccc(C(=O)NC2CC2)c2cc(-c3nc(Cl)ncc3Cl)sc12>>COc1ccc(C(=O)NC2CC2)c2cc(-c3nc(NCCCN4CCN(C)CC4)ncc3Cl)sc12,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20130338134A1,CN.COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]c(C(=O)O)cc4c3N(C)C2=O)c1>>CNC(=O)c1cc2c3c(cnc2[nH]1)CN(c1cc(OC)cc(OC)c1Cl)C(=O)N3C,,CN(C)C=O,CO,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US05952354,O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.Oc1ccc(-c2ccccc2)cc1>>O=C(Oc1ccc(-c2ccccc2)cc1)Oc1ccc([N+](=O)[O-])cc1,,ClCCl,,c1ccncc1,,val
US20040242572A1,CN1CCNCC1.N#CCc1ccc(C(=O)O)cc1>>CN1CCN(C(=O)c2ccc(CC#N)cc2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20130172329A1,COC(=O)c1ccc(Cl)nc1.Cc1onc(-c2ccc(F)cc2)c1CO>>COC(=O)c1ccc(OCc2c(-c3ccc(F)cc3)noc2C)nc1,,C1CCOC1,,[H-].[Na+],,val
US04616015,CC(=O)OC(C)C(=O)Cl.CC1NC(=O)NN=C1c1ccc(N)cc1>>CC(=O)OC(C)C(=O)Nc1ccc(C2=NNC(=O)NC2C)cc1,,CN(C)C=O,,CN(C)c1ccccc1,,val
US08618115B2,CN.COC(=O)c1cc([N+](=O)[O-])ccc1OC>>CNC(=O)c1cc([N+](=O)[O-])ccc1OC,,C1CCOC1,,CCO,,val
US20120184542A1,C1CCNCC1.COC(=O)CC(=O)OC.COc1ncc(C=O)c(N)n1>>COC(=O)c1cc2cnc(N3CCCCC3)nc2[nH]c1=O,,CO,,CC(=O)O,,val
US20150225367A1,Nc1ccc(-c2cn(S(=O)(=O)c3ccccc3)c3cc(F)ccc23)cn1.O=C(Cl)Oc1ccccc1>>O=C(Nc1ccc(-c2cn(S(=O)(=O)c3ccccc3)c3cc(F)ccc23)cn1)Oc1ccccc1,,c1ccncc1,,Cl,,val
US20050222248A1,C=C(C(=O)c1ccc(O)cc1O)c1ccc(O)c(O)c1>>CC(C(=O)c1ccc(O)cc1O)c1ccc(O)c(O)c1,[Pd],CO,,[H][H],,val
US20100298290A1,CI.S=c1[nH]c2ccc(-c3ccc4c(c3)CN(c3ccnc5ccccc35)CCO4)cc2[nH]1>>CSc1nc2ccc(-c3ccc4c(c3)CN(c3ccnc5ccccc35)CCO4)cc2[nH]1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US05539082,Cc1cn(N)c(=O)[nH]c1=O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cn(NC(=O)Cl)c(=O)[nH]c1=O,,C1CCOC1,C1CCOC1,,,val
US20100222339A1,CCC(CC)c1cc(C)nc2c(-c3sc(N4CCOCC4)nc3Cl)c(C)nn12.Cl>>CCC(CC)c1cc(C)nc2c(-c3sc(N4CCOCC4)nc3Cl)c(C)nn12.Cl,Cl,CC(C)=O,,,,val
US20140349990A1,CCOC(=O)c1nn(C2CC2)c(C(F)(F)F)c1C(O)c1ccc(Cl)cc1.Cn1cc(N)cc(Cl)c1=O>>CCOC(=O)c1nn(C2CC2)c(C(F)(F)F)c1C(Nc1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1,,CO,ClCCl,,,val
US20160130268A1,CC(C)(C)OC(=O)Nc1ccc(CCO)nc1.II>>CC(C)(C)OC(=O)Nc1ccc(CCI)nc1,,ClCCl,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100317582A1,C[C@@H](NC1CC(C(=O)O)C1)c1cccc2ccccc12.NC1CC1>>C[C@@H](NC1CC(C(=O)NC2CC2)C1)c1cccc2ccccc12,,CO,ClCCl,,,val
US20160166575A1,CCN1CCN(Cc2ccc(NC(=O)Cc3cccc(C#C[Si](C)(C)C)c3)cc2C(F)(F)F)CC1>>C#Cc1cccc(CC(=O)Nc2ccc(CN3CCN(CC)CC3)c(C(F)(F)F)c2)c1,,CO,,O,O=C([O-])[O-].[K+].[K+],val
US20080269196A1,CC(C)(C)C(=O)Nc1ccc(CN)cc1.O=C(N1CCc2ccc(Cl)c(OS(=O)(=O)C(F)(F)F)c2CC1)C(F)(F)F>>CC(C)(C)C(=O)Nc1ccc(CNc2c(Cl)ccc3c2CCN(C(=O)C(F)(F)F)CC3)cc1,,C1COCCO1,Cc1ccccc1,,,val
US20070244132A1,BrC(Br)(Br)Br.CC(O)(CCO)CCOC(=O)c1ccccc1>>CC(O)(CCBr)CCOC(=O)c1ccccc1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100105658A1,COC(=O)c1ccnc(Cl)c1.OB(O)O/C=C/c1ccccc1>>COC(=O)c1ccnc(/C=C/c2ccccc2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20020028835A1,CCOC(=O)CC(=O)Cl.Nc1ccc(N2CCC(=O)CC2)cc1>>CCOC(=O)CC(=O)Nc1ccc(N2CCC(=O)CC2)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US20130116243A1,CC(C)(C)OC(=O)NCc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.CCN1C(=O)COc2nc(Br)c(-c3ccccc3)cc21>>CCN1C(=O)COc2nc(-c3ccc(CNC(=O)OC(C)(C)C)cc3)c(-c3ccccc3)cc21,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130059836A1,COC(=O)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CO)CC1,,C1CCOC1,,,,val
US20150353498A1,COC(=O)CCCCC(=O)O.O=C(O)Cc1cc(Br)ccc1C(=O)O>>COC(=O)CCCCc1cc2cc(Br)ccc2c(=O)o1,,C1CCOC1,,Cl,,val
US20120046266A1,CCOC(=O)C(=O)CC(=O)c1c(OCc2ccccc2)cc(OCc2ccccc2)cc1Oc1ccc([N+](=O)[O-])cc1.NO>>CCOC(=O)c1cc(-c2c(OCc3ccccc3)cc(OCc3ccccc3)cc2Oc2ccc([N+](=O)[O-])cc2)on1,,CCO,,Cl,,val
US05843957,COc1cccc(-c2c(NC(=O)Nc3c(C(C)C)cccc3C(C)C)c(=O)n(C)c3ncccc23)c1>>CC(C)c1cccc(C(C)C)c1NC(=O)Nc1c(-c2cccc(O)c2)c2cccnc2n(C)c1=O,,ClCCl,,BrB(Br)Br,O=C([O-])O.[Na+],val
US20160184305A1,COc1cc2c(=O)ccn(C)c2cc1-c1ccc(N(C)C2CC(C)(C)NC(C)(C)C2)nn1.Cl>>CN(c1ccc(-c2cc3c(cc2O)c(=O)ccn3C)nn1)C1CC(C)(C)NC(C)(C)C1.Cl,,ClCCl,,BrB(Br)Br,CO,val
US08357717B2,COC(=O)Cc1ccc2c(n1)N(C(=O)OC(C)(C)C)CCC2.Cl>>COC(=O)Cc1ccc2c(n1)NCCC2.Cl,,CO,,,,val
US05439919,CC(C)(C)OC(=O)N(CCO)C(C)(C)C>>CC(C)(C)OC(=O)N(CC=O)C(C)(C)C,,CS(C)=O,,CCN(CC)CC,ClCCl,val
US20070037820A1,OCc1cc(-c2cccc(I)c2)on1>>O=Cc1cc(-c2cccc(I)c2)on1,,CCOC(C)=O,ClCCl,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20060281789A1,CI.CN(C)Cc1n[nH]c2ccccc12>>C[N+](C)(C)Cc1n[nH]c2ccccc12.[I-],,CCOC(C)=O,,,,val
US05919793,C=CCBr.CCOC(=O)COc1ccc(O)cc1>>C=CCOc1ccc(OCC(=O)OCC)cc1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080132497A1,CCOC(=O)Cc1ccc2c(c1)sc1nc[nH]c(=O)c12.O=P(Cl)(Cl)Cl>>CCOC(=O)Cc1ccc2c(c1)sc1ncnc(Cl)c12,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US20070203157A1,C=C(C)O[Si](C)(C)C.COc1ccc(NS(=O)(=O)Cl)cc1>>COc1ccc(NS(=O)(=O)CC(C)=O)cc1,,CC#N,,CCN(CC)CC,,val
US20020115640A1,CCCBr.Cn1cncc1C(OCc1ccc(C#N)cc1-c1ccc(=O)[nH]c1)c1ccc(C#N)cc1>>CCCn1cc(-c2cc(C#N)ccc2COC(c2ccc(C#N)cc2)c2cncn2C)ccc1=O,,CN(C)C=O,,[H-].[Na+],,val
US06110949,NC1CCCCC1.O=C(CBr)OCc1ccccc1>>CC(=O)O.c1ccc(CNC2CCCCC2)cc1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20140187556A1,CC(=O)c1cccc(-c2ccc([N+](=O)[O-])c(NCc3ccccc3)c2)c1>>CC(O)c1cccc(-c2ccc([N+](=O)[O-])c(NCc3ccccc3)c2)c1,,CO,,[BH4-].[Na+],,val
US20020022609A1,CC[C@@H]1Cc2cc(OC)ccc2[C@H]2CC[C@]3(C)C(=O)CC=C3[C@@H]21>>CC[C@@H]1Cc2cc(OC)ccc2[C@H]2CC[C@@]3(C)C(=CC[C@@H]3O)[C@@H]21,,CO,ClCCl,[Na+].[OH-],,val
US06498165B1,CCCc1cc(-n2cnc3ccccc32)nc(SCC)n1.O=S([O-])OO>>CCCc1cc(-n2cnc3ccccc32)nc(S(=O)(=O)CC)n1,,CO,,O,,val
US20060154988A1,CCc1ccc(-c2ccc(C(=O)N[C@H](C(=O)OC)[C@@H](C)N=[N+]=[N-])cc2)cc1>>CCc1ccc(-c2ccc(C(=O)N[C@H](C(=O)OC)[C@@H](C)N)cc2)cc1,,CO,,,,val
US20160030395A1,COC(=O)CC1(c2ccccc2)C(=O)Nc2ccc(-c3c(C)noc3C)cc21>>Cc1noc(C)c1-c1ccc2c(c1)C(CCO)(c1ccccc1)C(=O)N2,,CCO,,[BH4-].[Na+],,val
US20100292455A1,CCCCCCCCC1CCC2C3CC=C4CC(OC(=O)NCCCCCC(=O)N5CC(O)CC5C(OC(c5ccc(OC)cc5)c5ccc(OC)cc5)c5ccccc5)CCC4(C)C3CCC12C.O=C1CCC(=O)O1>>CCCCCCCCC1CCC2C3CC=C4CC(OC(=O)NCCCCCC(=O)N5CC(OC(=O)CCC(=O)O)CC5C(OC(c5ccc(OC)cc5)c5ccc(OC)cc5)c5ccccc5)CCC4(C)C3CCC12C,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20090163512A1,CC1(COc2ccc(Cl)cc2C=O)COC1.O=C1Cc2ccc(Cl)cc2N1>>CC1(COc2ccc(Cl)cc2/C=C2\C(=O)Nc3cc(Cl)ccc32)COC1,,CO,,C1CCNC1,,val
US20100222324A1,CC(C)(C)OC(=O)N1CCC2(CCC(N3CCC3)CC2)CC1>>C1CN(C2CCC3(CCNCC3)CC2)C1,,CO,,Cl,,val
US20110112063A1,CC(C)c1ncon1.CN1CCCC1=O.Cc1cc(Nc2nc(Nc3cc(C)c(C4CCNCC4)cc3C)ncc2Cl)n[nH]1>>Cc1cc(Nc2nc(Nc3cc(C)c(C4CCN(CCc5nc(C(C)C)no5)CC4)cc3C)ncc2Cl)n[nH]1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US05214037,O=C(Cc1cccs1)OCCl.Sc1ccccn1>>CC(=O)SCSc1ccccn1,,CCOC(C)=O,,CN(C)C=O,[H-].[Na+],val
US20040058820A1,COC(=O)Cc1ccccc1.Clc1ccc(CBr)cc1>>COC(=O)C(Cc1ccc(Cl)cc1)c1ccccc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US04260767,O=C(Cc1cccc(Cl)n1)N(F)N(F)F.O=C(Cl)CCl>>NNC(=O)C(Cl)c1cccc(Cl)n1,,ClCCl,,c1ccncc1,,val
US20060264429A1,O=C1CCC2(CC1)OCCO2.O=C1COc2ccc(Br)cc2N1>>O=C1COc2ccc(C3(O)CCC4(CC3)OCCO4)cc2N1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20160185785A1,CCOC(=O)C(=CN(C)C)C(=O)C(C)c1ccccc1.CNN>>CCOC(=O)c1cn(C)nc1C(C)c1ccccc1,,O,,CCN(CC)CC,CCO,val
US20150284395A1,CCCc1nn2c(=O)cc(-c3ccc4c(cnn4CC)c3)[nH]c2c1C#N.O=S(=O)(O)O>>CCCc1nn2c(=O)cc(-c3ccc4c(cnn4CC)c3)[nH]c2c1C(N)=O,,O,,,,val
US05426187,C#Cc1c[nH]c2nc(NC(=O)C(C)(C)C)nc(O)c12.CCOC(=O)CC[C@H](NC(=O)c1ccc(I)cc1)C(=O)OCC>>CCOC(=O)CC[C@H](NC(=O)c1ccc(C#Cc2c[nH]c3nc(NC(=O)C(C)(C)C)nc(O)c23)cc1)C(=O)OCC,Cl[Pd]Cl,CC#N,O,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030153577A1,CC(C)C(O)CC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1>>CC(C)C(=O)CC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1,,CN(C)C=O,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20020032202A1,CC(C)I.CCCCCC.CCOC(C)=O.O=C(O)c1cnc(O)c(Cl)c1>>CC(C)OC(=O)C1(OC(C)C)C=C(Cl)C=NC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120184574A1,BrBr.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)c(OC(F)F)cc3n2C2CCC2)nc1)C(F)(F)F>>C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3c(Br)c(F)c(OC(F)F)cc3n2C2CCC2)nc1)C(F)(F)F,[Fe],ClCCCl,,O=S([O-])O.[Na+],,val
US20070010670A1,O=C(c1cc(Cl)c(OCc2ccccc2)c(Cl)c1)N1CCS(=O)(=O)c2ccccc21>>O=C(c1cc(Cl)c(O)c(Cl)c1)N1CCS(=O)(=O)c2ccccc21,,Cc1ccccc1,,O=C(O)C(F)(F)F,,val
US20100305135A1,CC1(C)O[C@@H]2[C@@H](CC[C@H]2c2cnc3c(N)nccn23)O1>>Nc1nccn2c([C@@H]3CC[C@@H](O)[C@H]3O)cnc12,,CO,,Cl,,val
US20080171755A1,COC(OC)N(C)C.Cc1nccc(C(=O)Cc2ccc3ncnn3c2)n1.NN>>Cc1nccc(-c2n[nH]cc2-c2ccc3ncnn3c2)n1,,CN(C)C=O,,CC(=O)O,O,val
US20050107364A1,CC(C)CC[C@@](C)(C(=O)N[C@H](CO)c1ccccc1)c1ccccc1.O=S(=O)(O)O>>CC(C)CC[C@](C)(C(=O)O)c1ccccc1,,C1COCCO1,,,,val
US20120196864A1,CI.CNC1=NC(=O)S/C1=C\c1ccc(OCc2ccc(C(F)(F)F)cc2C(F)(F)F)c(F)c1>>C/N=C1C(=C\c2ccc(OCc3ccc(C(F)(F)F)cc3C(F)(F)F)c(F)c2)\SC(=O)N\1C,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080167371A1,N#Cc1cccc(-c2ccc(CO)cc2Cl)c1.OO>>NC(=O)c1cccc(-c2ccc(CO)cc2Cl)c1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US04898871,COc1ccc2ccc(N3C(=O)c4ccccc4C3O)nc2n1.O=C(CCl)NC1CCCCC1>>COc1ccc2ccc(N3C(=O)c4ccccc4C3OCC(=O)NC3CCCCC3)nc2n1,,CN(C)C=O,,O,[H-].[Na+],val
US20130102586A1,CN1CCN(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.COc1ccc(Cn2nc(C)c3cc(Br)cnc32)cc1>>COc1ccc(Cn2nc(C)c3cc(-c4ccc(N5CCN(C)CC5)cc4)cnc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US06403625B1,CC1=Nc2ccc3ccccc3c2C1(C)C.CCI>>CC[N+]1=C(C)C(C)(C)c2c1ccc1ccccc21.[I-],,CC#N,,,,val
US20020045780A1,Cc1cc(C)c(S(=O)(=O)N(CCCC#N)CCCCC#N)c(C)c1>>Cc1cc(C)c(S(=O)(=O)N(CCCCN)CCCCCN)c(C)c1,[Ni],C1CCOC1,CO,[NH4+].[OH-],,val
US06825181B1,CCOC(=N)c1ccc(C(=O)OCC)cc1.CNC>>CCOC(=O)c1ccc(C(=N)N(C)C)cc1,,CCO,,Cl,,val
US04332944,Clc1ccc(CBr)cn1.O=[N+]([O-])c1ccc(O)c(Cl)c1>>O=[N+]([O-])c1ccc(OCc2ccc(Cl)nc2)c(Cl)c1,,C1CCOC1,O,[H-].[Na+],,val
US20100010008A1,CCOC(=O)n1nc2c(c1NC(=O)c1ccc(N3CCN(C)CC3)cc1)CN(C(=O)Nc1c(Cl)cccc1Cl)C2(C)C>>CN1CCN(c2ccc(C(=O)Nc3[nH]nc4c3CN(C(=O)Nc3c(Cl)cccc3Cl)C4(C)C)cc2)CC1,,CO,,,,val
US20160028021A1,Clc1cc(Br)cc(-c2ccccc2)c1.OB(O)c1cccc2c1sc1ccccc12>>Clc1cc(-c2ccccc2)cc(-c2cccc3c2sc2ccccc23)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,O,,,val
US20140275096A1,NNC(=O)c1cccnc1.O=C1C(=S)NCC(C2CC2)N1Cc1cccc(C(F)(F)F)c1Cl>>O=C1c2nnc(-c3cccnc3)n2CC(C2CC2)N1Cc1cccc(C(F)(F)F)c1Cl,,CCCCO,,,,val
US05753665,CC(Br)c1ccnc2ncnn12.Oc1cccc(Cl)c1>>CC(Oc1cccc(Cl)c1)c1ccnc2ncnn12,,COCCOC,,[H-].[Na+],,val
US20080255086A1,CCOC(=O)c1c[nH]nc1C(F)(F)F.NC(=O)c1c(NC(=O)CBr)sc2c1CCCC2>>CCOC(=O)c1cn(CC(=O)Nc2sc3c(c2C(N)=O)CCCC3)nc1C(F)(F)F,,CN(C)C=O,,O,[H-].[Na+],val
US20060217380A1,CNc1ncc(C#C[Si](C)(C)C)c(-c2cccs2)n1>>C#Cc1cnc(NC)nc1-c1cccs1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20120202783A1,COC(=O)c1cc(F)ccc1-c1ncccn1>>O=C(O)c1cc(F)ccc1-c1ncccn1,,O,,[Na+].[OH-],,val
US20150133428A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1c(I)nn2c1CNC1(CC1)C2>>CCOC(=O)c1c(I)nn2c1CN(C(=O)OC(C)(C)C)C1(CC1)C2,,ClCCl,,,,val
US05329052,C/C(C=O)=C\C[C@H]1C[C@H]2C[C@@H]([C@@H]1C)C2(C)C>>CC(C=O)CC[C@H]1C[C@H]2C[C@@H]([C@@H]1C)C2(C)C,[Pd],CCCCCC,,,,val
US20100152183A1,CC(C)(C)OC(=O)N1CC[C@@H](Nc2ccc(S(N)(=O)=O)cc2[N+](=O)[O-])C1>>NS(=O)(=O)c1ccc(N[C@@H]2CCNC2)c([N+](=O)[O-])c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060270726A1,CC(C)(C)OC(=O)N1CCC(CO)CC1.Oc1c(Cl)cc(OCc2ccccc2)cc1Cl>>CC(C)(C)OC(=O)N1CCC(COc2c(Cl)cc(OCc3ccccc3)cc2Cl)CC1,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04022769,CC(=O)OC[C@]12CC[C@H](O)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](OC(C)=O)CC[C@@H]12.C[Si](C)(C)Cl>>CC(=O)OC[C@]12CC[C@H](O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](OC(C)=O)CC[C@@H]12,,Cc1ccccc1,,c1ccncc1,,val
US08080566B1,CCBr.COC(=O)c1cccc2c1[nH]c1ccccc12>>CCn1c2ccccc2c2cccc(C(=O)OC)c21,,CN(C)C=O,,[H-].[Na+],,val
US05273975,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cccc2[nH]cnc12>>Cc1cccc2c1ncn2C(=O)OC(C)(C)C,,C1COCCO1,,,,val
US20150210682A1,COCCCOc1cc(CC(N)C(C)C)cc(F)c1F.O=CO>>COCCCOc1cc(CC(NC=O)C(C)C)cc(F)c1F,,C1COCCO1,,,,val
US20080242672A1,CNCCN(C)c1ccc(F)cc1F.Nc1nc(Cl)c2ccn(CCBr)c2n1>>CN(CCN(C)c1ccc(F)cc1F)CCn1ccc2c(Cl)nc(N)nc21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05707982,CC(C)(C)[Si](C)(C)Cl.OCCCCCCCCBr>>CC(C)(C)[Si](C)(C)OCCCBr,,C1CCOC1,,CN(C)C=O,c1c[nH]cn1,val
US20010027196A1,CSc1nc(N)nc(-c2ccco2)c1C#N.NCc1ccccc1>>N#Cc1c(NCc2ccccc2)nc(N)nc1-c1ccco1,,CCO,,,,val
US20100105713A1,CC(C)(C)OC(=O)N1CCC2(CC1)N=C(c1ccc(Cl)cc1)C(=O)N2.Cc1cc(C(=O)CBr)ccc1Cl>>Cc1cc(C(=O)CN2C(=O)C(c3ccc(Cl)cc3)=NC23CCN(C(=O)OC(C)(C)C)CC3)ccc1Cl,,CN(C)C=O,,[H-].[Na+],,val
US20110178132A1,N#Cc1cc(Cl)ccn1.OB(O)c1ccccc1OC(F)(F)F>>N#Cc1cc(-c2ccccc2OC(F)(F)F)ccn1,,C1COCCO1,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US06350907B1,CCC[C@H](C(=O)OC(C)(C)C)[C@@H](C/C=C/c1ccc(-c2ccccc2)c(C)c1)C(=O)N[C@H](C(=O)N[C@H](C)c1ccccc1)C(C)(C)C>>CCC[C@H](C(=O)OC(C)(C)C)[C@@H](CCCc1ccc(-c2ccccc2)c(C)c1)C(=O)N[C@H](C(=O)N[C@H](C)c1ccccc1)C(C)(C)C,[Pd],CCO,,,,val
US20060100431A1,CC(C)(C)OC(=O)N1C[C@H](O)[C@H]2NOC[C@H]21.O=C(Cl)OCC1c2ccccc2-c2ccccc21>>CC(C)(C)OC(=O)N1C[C@H](O)[C@@H]2[C@H]1CON2C(=O)OCC1c2ccccc2-c2ccccc21,,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100009956A1,N#Cc1ncc(Cl)c(N(N)C2CCCC2)n1.O=C(Br)c1ccc(CBr)cc1>>N#Cc1ncc(Cl)c(N(NC(=O)c2ccc(CBr)cc2)C2CCCC2)n1,,C1CCOC1,O,CCN(C(C)C)C(C)C,CCOC(C)=O,val
US20090286791A1,CC(C)(C)OC(=O)Nc1nn(-c2ccccc2)cc1C(=O)NCCNC(=O)c1ccc(OCC(F)(F)F)nc1>>Nc1nn(-c2ccccc2)cc1C(=O)NCCNC(=O)c1ccc(OCC(F)(F)F)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120101083A1,Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(CO)CO)C2.Cl>>Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(CO)CO)C2.Cl,,CC(C)O,ClCCl,CCOCC,,val
US20110003820A1,CNC(=O)c1ccc2n1CCN(C(=O)OC(C)(C)C)C2C>>CNC(=O)c1ccc2n1CCNC2C,,CO,,Cl,,val
US20050197350A1,COc1cccc(C(=O)Cl)c1.N[C@@H]1CC[C@H](Nc2ccc3ccccc3n2)CC1>>COc1cccc(C(=O)N[C@@H]2CC[C@H](Nc3ccc4ccccc4n3)CC2)c1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20160200674A1,Cc1ccc(NC(=O)Nc2cc(Br)cc(F)c2N(CC(C)C)CC(C)C)cc1.OB(O)c1ccccc1-c1nnn[nH]1>>Cc1ccc(NC(=O)Nc2cc(-c3ccccc3-c3nnn[nH]3)cc(F)c2N(CC(C)C)CC(C)C)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US20050277619A1,NCCP(=O)([O-])[O-].Nc1ncnc2c1nc(Br)n2Cc1ccccc1>>Nc1ncnc2c1nc(NCCP(=O)(O)O)n2Cc1ccccc1,,CCO,O,[Na+].[OH-],,val
US20110065681A1,Cc1ccc(-c2cc(Oc3nccs3)cc(C(=O)O)c2)nc1.Cc1ncc([C@@H](C)N)cn1>>Cc1ccc(-c2cc(Oc3nccs3)cc(C(=O)N[C@H](C)c3cnc(C)nc3)c2)nc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120220609A1,CCOC(=O)C(F)(F)c1ccc(-c2ccc(Br)cc2)cc1.C[Mg]I>>CC(C)(O)C(F)(F)c1ccc(-c2ccc(Br)cc2)cc1,,C1CCOC1,,CCOCC,Cl,val
US20070135385A1,CCOC(=O)C(Br)C(C)C.Cc1cc2c(O)cccc2n1Cc1ccccc1>>CCOC(=O)C(Oc1cccc2[nH]c(C)cc12)C(C)C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05744165,CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1>>CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1,,O,,[Na],,val
US20100261732A1,COc1ccccc1N1CCN(CCC(=O)NN)CC1.O=C=NC1CCCCCCC1>>COc1ccccc1N1CCN(CCC(=O)NNC(=O)NC2CCCCCCC2)CC1,,Cc1ccccc1,,CCCCCC,,val
US20130274255A1,Brc1ccc(-c2n[nH]c3c2Cc2sccc2-3)cn1.C[Si](C)(C)CCOCCl>>C[Si](C)(C)CCOCn1nc(-c2ccc(Br)nc2)c2c1-c1ccsc1C2,,C1CCOC1,,[H-].[Na+],,val
US20120264735A1,OCC(F)(CBr)COCc1ccccc1>>FC1(COCc2ccccc2)COC1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20060183790A1,CCS(=O)(=O)Cl.N=C(N)NC(=O)Cn1c(-c2ccccc2)ccc1C12CC3CC(CC(C3)C1)C2>>CCS(=O)(=O)N/C(N)=N\C(=O)Cn1c(-c2ccccc2)ccc1C12CC3CC(CC(C3)C1)C2,,ClCCl,,CCN(CC)CC,,val
US20070265265A1,Nc1ccc(-c2csc(NC(=O)[C@@H]3CCCN3C(=O)OCc3ccccc3)n2)cc1.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21>>O=C(CCCCC1SCC2NC(=O)NC21)Nc1ccc(-c2csc(NC(=O)C3CCCN3C(=O)OCc3ccccc3)n2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120129811A1,COc1ccc(C(N)=O)cc1N.O=C(N=C=S)c1ccccc1>>COc1ccc(C(N)=O)cc1NC(N)=S,,CC(C)=O,,O,,val
US20110028445A1,Cc1ccnc(C#Cc2ccccc2)c1>>Cc1ccnc(CCc2ccccc2)c1,[Pd],CO,,,,val
US04749812,CC(C)c1ccc(N)cc1Cl.CCCC(C)C(=O)Cl>>CCCC(C)C(=O)Nc1ccc(C(C)C)c(Cl)c1,,c1ccncc1,,Cc1ccccc1,,val
US05935995,COC(=O)[C@H]1O[C@](O)(c2ccc([N+](=O)[O-])cc2N(C)C(=O)OC(C)(C)C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CNc1cc([N+](=O)[O-])ccc1[C@@]1(O)O[C@H](C(=O)OC)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O,,CCOC(C)=O,Cl,O=C([O-])O.[Na+],,val
US20030125370A1,N#CCCl.Oc1ccncc1>>N#CCN1CCC(O)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090181955A1,COc1ccc2nccc(OS(=O)(=O)C(F)(F)F)c2n1.O=C1CNCCN1CCN1C(=O)c2ccccc2C1=O>>COc1ccc2nccc(N3CCN(CCN4C(=O)c5ccccc5C4=O)C(=O)C3)c2n1,,CCO,,,,val
US05665725,COC(=O)c1csc2ccccc12>>OCc1csc2ccccc12,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070185329A1,CCOC(=O)Cl.O[C@H]1CN2CCC1CC2>>CCOC(=O)O[C@H]1CN2CCC1CC2,CN(C)c1ccncc1,ClC(Cl)Cl,,CCN(CC)CC,O,val
US20040077668A1,COC(CNC(c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1)C(C)C)OC.O=C(Cl)c1ccccc1>>COC(CN(C(=O)c1ccccc1)C(c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1)C(C)C)OC,,ClCCl,,CCN(CC)CC,,val
US20120028953A1,Cc1nnc(N)o1.O=C(Oc1ccc([N+](=O)[O-])cc1)N1CC(Oc2ccc(-c3ccccc3F)cn2)C1>>Cc1nnc(NC(=O)N2CC(Oc3ccc(-c4ccccc4F)cn3)C2)o1,,CN(C)C=O,,[H-].[Na+],,val
US20110207716A1,CC[C@@H]1C(=O)N(C)c2cnc(-n3ccnc3Br)nc2N1C1CCCC1.CS(=O)(=O)c1ccc(B(O)O)cc1>>CC[C@@H]1C(=O)N(C)c2cnc(-n3ccnc3-c3ccc(S(C)(=O)=O)cc3)nc2N1C1CCCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,[Na+].[OH-],,val
US20120035196A1,CCC(=O)NCCCOc1cc(C)c(-c2cccc(CO)c2C)c(C)c1.ClCCl>>CCC(=O)N(C)CCCOc1cc(C)c(-c2cccc(CO)c2C)c(C)c1,,ClCCl,,CCN(CC)CC,C[Si](C)(C)Cl,val
US20160000760A1,Nc1nc(Nc2cc(Cl)c(Br)c(C(F)(F)F)c2)n[nH]1.O=S(=O)(CC1CC1)c1ccc(B(O)O)cc1>>Nc1nc(Nc2cc(Cl)c(-c3ccc(S(=O)(=O)CC4CC4)cc3)c(C(F)(F)F)c2)n[nH]1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,COCCOC,O=C([O-])[O-].[K+].[K+],val
US04277394,CCC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](Cc1cn(S(=O)(=O)c2ccc(C)cc2)cn1)NC(=O)OC(C)(C)C>>CCC(=O)NNC(=O)CNC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)OC(C)(C)C,,CO,,[Na+].[OH-],,val
US06207693B1,COc1cc(C(=O)N(C)c2ccc(C)cc2OCCCCCC(=O)N2CCN(C)CC2)ccc1NC(=O)c1cccc(N)c1N.O=C(O)CS>>COc1cc(C(=O)N(C)c2ccc(C)cc2OCCCCCC(=O)N2CCN(C)CC2)ccc1NC(=O)c1cccc2[nH]c(CS)nc12,,ClC(Cl)Cl,,,,val
US05962487,CC(C)(C)OC(=O)[C@@H]1CCCCN1C(=O)OCc1ccccc1.CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)O>>CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCCC[C@H]1C(=O)OC(C)(C)C,[Pd],CCOC(C)=O,,,,val
US06121279,CCOc1cc([C@@H]2CCCC[C@@H]2N)ccc1OC.NS(=O)(=O)c1ccc(C(=O)Cl)cc1>>CCOc1cc([C@H]2CCCC[C@H]2NC(=O)c2ccc(S(N)(=O)=O)cc2)ccc1OC,,CCN(CC)CC,ClCCl,,,val
US05286905,CC(COc1cc(C)cc(C)c1)=NO>>Cc1cc(C)cc(OCC(C)N)c1,[Ni],CCO,,,,val
US20100056565A1,Cl[Mg]C1CCCCC1.O=C(c1ccccc1)c1noc(CCl)n1>>OC(c1ccccc1)(c1noc(CCl)n1)C1CCCCC1,,C1CCOC1,,,,val
US20130165464A1,Clc1ccccc1-c1cc[nH]n1.O=C1CCC(=O)N1Br>>Clc1ccccc1-c1n[nH]cc1Br,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20150376172A1,C[C@@]1(c2c(F)ccc([N+](=O)[O-])c2F)C[C@@H](C(F)(F)F)OC(N)=N1>>C[C@@]1(c2cccc(N)c2F)C[C@@H](C(F)(F)F)OC(N)=N1,[Pd],CCO,,CCN(CC)CC,,val
US20150158826A1,Nc1ccc(F)c(C(=O)c2ccc3nccnc3c2)c1.O=C(Cl)c1cccc(F)c1>>O=C(Nc1ccc(F)c(C(=O)c2ccc3nccnc3c2)c1)c1cccc(F)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20040058978A1,O=C1Nc2ccccc2/C1=C(/Nc1cccc([N+](=O)[O-])c1)c1ccccc1>>Nc1cccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)c1,[Pd],C1CCOC1,,[H][H],,val
US20120277217A1,O=[N+]([O-])c1ccccc1-c1cnc[nH]1>>Nc1ccccc1-c1cnc[nH]1,,CO,,NN,,val
US20130040997A1,CCOC(=O)C=Cc1cnc(C)c2c1COC(C)(C)O2>>CCOC(=O)C=Cc1cnc(C)c(O)c1CO,,O=CO,,,,val
US20150175557A1,CCOC1CC(Nc2nc(SC)ncc2C#N)C1(C)C>>CSc1ncc(C#N)c(NC2CC(O)C2(C)C)n1,,ClCCl,,BrB(Br)Br,,val
US20150191461A1,CC1(C)OB(c2cn[nH]c2)OC1(C)C.COc1ccc(CN2CC(COS(C)(=O)=O)CC2=O)c(OC)c1>>COc1ccc(CN2CC(Cn3cc(B4OC(C)(C)C(C)(C)O4)cn3)CC2=O)c(OC)c1,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20070049593A1,COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccccc3SCCO)[nH]c2c1.CS(=O)(=O)Cl>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccccc3SCCOS(C)(=O)=O)[nH]c2c1,,ClC(Cl)Cl,,CCN(CC)CC,O,val
US06462036B1,CN(C)C=O.ClCCl.O=C(Cl)c1ccc(-n2ncc3c2-c2ccccc2C3)cc1.O=C(O)c1ccc(-c2n[nH]c3c2Cc2ccccc2-3)cc1>>O=C(OCCN1CCOCC1)c1ccc(-c2n[nH]c3c2Cc2ccccc2-3)cc1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20110212998A1,Cc1cc(C#N)cc(CO)n1.NO>>Cc1cc(C(=N)NO)cc(CO)n1,,CO,,Cl,,val
US20100150831A1,CN1CCNCC1.COc1ccc2cccnc2c1N1CCCN(C(CC(=O)O)c2csc(N3CCC(O)CC3)n2)CC1>>COc1ccc2cccnc2c1N1CCCN(C(CC(=O)N2CCN(C)CC2)c2csc(N3CCC(O)CC3)n2)CC1,,CN(C)C=O,ClCCl,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130289029A1,C=O.CC(C)(C)OC(=O)N[C@@H]1CCNC1>>CN1CC[C@@H](NC(=O)OC(C)(C)C)C1,,O,,CO,[BH4-].[Na+],val
US20080234255A1,CCOC(=O)C(C)C(C)N(c1nc(Cl)ncc1N)C1CC1>>CC1C(=O)Nc2cnc(Cl)nc2N(C2CC2)C1C,,CC(=O)O,,CCO,,val
US20110015157A1,C=CC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(OC)cc2)C(=O)O1>>C=CC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(O)cc2)C(=O)O1,,ClCCl,,BrB(Br)Br,,val
US05726124,C#CCn1c(-c2ccccc2)nc(CC)c(OC)c1=O>>C#CCn1c(-c2ccccc2)nc(CC)c(O)c1=O,,O,,,,val
US06172228B2,CCN(CC)S(=O)(=O)CCCCCCCl.Clc1ccc(C(c2ccccc2)N2CCNCC2)cc1>>CCN(CC)S(=O)(=O)CCCCCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1,,CCN(C(C)C)C(C)C,,,,val
US20140256756A1,CS(=O)(=O)c1ccc(N[C@H]2CCN(C3CCN(c4nc([C@H]5COC6(CCCCC6)O5)ns4)CC3)C2=O)c(F)c1>>CS(=O)(=O)c1ccc(N[C@H]2CCN(C3CCN(c4nc([C@H](O)CO)ns4)CC3)C2=O)c(F)c1,,CCO,,Cl,O,val
US20150284395A1,CN(C)C=C(C#N)c1ccnn1C.NN>>Cn1nccc1-c1cn[nH]c1N,,CC(=O)O,,O,,val
US06319902B1,CCCCCCCCCCCCCCO.O=C(O)CNC(=O)OCc1ccccc1>>CCCCCCCCCCCCCCOC(=O)CNC(=O)OCc1ccccc1,,CCOC(C)=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060019991A1,CC(C)(C)[Si](C)(C)O[C@@H](CBr)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12.NCCc1ccc(Oc2cccc(Cl)c2)cc1>>CC(C)(C)[Si](C)(C)O[C@@H](CNCCc1ccc(Oc2cccc(Cl)c2)cc1)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12,,CS(C)=O,ClCCl,[I-].[K+],O=C([O-])O.[Na+],val
US20060211706A1,CC(C)(C)OC(=O)Nc1cccc(COS(C)(=O)=O)c1.c1c[nH]cn1>>CC(C)(C)OC(=O)Nc1cccc(Cn2ccnc2)c1,,CN(C)C=O,,[Na],,val
US20010002398A1,Nc1nc2c(c(=O)[nH]1)N[C@@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)CN2>>Nc1nc2c(c(=O)[nH]1)NC(CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)CN2,,O,,Cl,,val
US04232163,C=C1CC(=O)O1.CC(C)Nc1ccc(Cl)cc1>>CC(=O)CC(=O)N(c1ccc(Cl)cc1)C(C)C,,O,,CC(=O)O,,val
US20150239866A1,Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(C(=O)NNC(=O)OC(C)(C)C)c1.Cl>>Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(C(=O)NN)c1.Cl,,CCOC(C)=O,,,,val
US20160002194A1,COc1cc(C(C)N(C)C)cc2oc(=O)c3ccccc3c12>>CC(c1cc(O)c2c(c1)oc(=O)c1ccccc12)N(C)C,,CC(C)=O,,Br,O=C([O-])O.[Na+],val
US20150152097A1,COCCC1(Cn2ncc(-c3ccc(N4CCc5cccc(C(=O)Nc6nc7ccccc7s6)c5C4)nc3C(=O)O)c2C)CCCCCC1.CS(N)(=O)=O>>COCCC1(Cn2ncc(-c3ccc(N4CCc5cccc(C(=O)Nc6nc7ccccc7s6)c5C4)nc3C(=O)NS(C)(=O)=O)c2C)CCCCCC1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20130190290A1,CN(C)C=O.O=C(O)c1cc(Br)cc(S(F)(F)(F)(F)F)c1>>O=Cc1cc(C(=O)O)cc(S(F)(F)(F)(F)F)c1,,C1CCOC1,CCOCC,CC(C)[Mg]Cl,Cl,val
US20160152599A1,COC(=O)c1c[nH]c2ccccc12.O=C(O)c1ccccc1I>>COC(=O)c1cn(-c2ccccc2C(=O)O)c2ccccc12,I[Cu]I,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20150038510A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cn1cnc2cc(Br)ccc21>>Cn1cnc2cc(B3OC(C)(C)C(C)(C)O3)ccc21,,C1COCCO1,,CC(=O)[O-].[K+],,val
US05002641,Cc1cccnc1C.O.O=C(O)c1cccnc1C(=O)O>>Cc1cccnc1C.O.O=C(O)c1cccnc1C(=O)O,,O,,,,val
US20090118201A1,CC(=O)OC(C)=O.CC(=O)OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(C(C)=O)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>C=C(C)c1ccc(Cc2cc([C@@H]3O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)ccc2Cl)cc1,CN(C)c1ccncc1,Cc1ccccc1,ClCCl,c1ccncc1,,val
US20130150343A1,CC(C)[Si](OCC1CCN(c2nnc3ccc(O[C@@H]4CC[C@H](N)c5ccccc54)cn23)CC1)(C(C)C)C(C)C.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)cc1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCC(CO[Si](C(C)C)(C(C)C)C(C)C)CC5)n4c3)c3ccccc32)cc1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20050187266A1,COC(=O)C(C)(C)Br.N#Cc1cccc(O)c1>>COC(=O)C(C)(C)Oc1cccc(C#N)c1,,CC#N,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20150152108A1,O=[N+]([O-])c1cc(-c2cnco2)cc(-c2cnco2)c1>>Nc1cc(-c2cnco2)cc(-c2cnco2)c1,[Pd],CCOC(C)=O,,,,val
US20130040983A1,Brc1nc(-c2ccccc2)[nH]c1Br.COc1cc(B(O)O)ccn1>>COc1cc(-c2[nH]c(-c3ccccc3)nc2Br)ccn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20010051631A1,Cc1nc2cccc3n(CCCCCCN)c(=O)c1n23.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1nc2cccc3n(CCCCCCNS(=O)(=O)C(F)(F)F)c(=O)c1n23,,ClCCl,,CCN(CC)CC,,val
US20060183756A1,CC(=O)Nc1nc(C)c(S(=O)(=O)N2CCC(O)C2)s1>>Cc1nc(N)sc1S(=O)(=O)N1CCC(O)C1,,Cl,,,,val
US05409956,CCOC(=O)/C=C/c1ccc2c(c1)CC(CNS(=O)(=O)c1ccc(Cl)cc1)C2>>CCOC(=O)CCc1ccc2c(c1)CC(CNS(=O)(=O)c1ccc(Cl)cc1)C2,,CCO,,[BH4-].[Na+],,val
US20100039688A1,O=C(Cl)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.Oc1ccc(-c2ccc(-c3cc4c(c5ccccc35)C=CC(c3ccccc3)(c3ccc(N5CCCC5)cc3)O4)cc2)cc1>>O=C(Oc1ccc(-c2ccc(-c3cc4c(c5ccccc35)C=CC(c3ccccc3)(c3ccc(N5CCCC5)cc3)O4)cc2)cc1)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,CN(C)c1ccncc1,ClCCl,,Cl,c1ccncc1,val
US20070155839A1,CC1(C)CC(=C(c2ccc(O)cc2)c2ccc(Br)cc2)CC(C)(C)C1.CS(=O)(=O)c1ccc(B(O)O)cc1>>CC1(C)CC(=C(c2ccc(O)cc2)c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2)CC(C)(C)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20060211689A1,CN1CCN(c2ccc3nc(N)c(C#N)c(Cl)c3c2)CC1.NCc1ccccc1>>CN1CCN(c2ccc3nc(N)c(C#N)c(NCc4ccccc4)c3c2)CC1,,O,,,,val
US20040132727A1,COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.NC1CCN(Cc2ccccc2)CC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3cc(C)c(NC(=O)NC4CCN(Cc5ccccc5)CC4)cc3C)c2cc1OC,,ClC(Cl)Cl,O,CCN(CC)CC,,val
US20020013460A1,CCN1CCN(c2nc(-c3cc(F)c(OCCO[Si](C)(C)C(C)(C)C)c(F)c3)cc3ccccc23)CC1>>CCN1CCN(c2nc(-c3cc(F)c(OCCO)c(F)c3)cc3ccccc23)CC1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05219868,CCOC(=O)c1ccc(N)cc1.CCOC([O-])[O-].CN1CCN(C)C1=O.O=[N+]([O-])N=C1NCCN1>>CCOC1=CC(=C=O)C(N=CN2CCNC2=N[N+](=O)[O-])C=C1,,CCOC(C)=O,,,,val
US04845242,O=C(NCCCO)OCc1ccccc1.O=C(O)Cc1ccccc1C(=O)O>>O=C(Cc1ccccc1C(=O)O)OCCCNC(=O)OCc1ccccc1,O=S(=O)(O)O,c1ccccc1,,,,val
US20050107354A1,CCOC(=O)COc1cc(C(C)C)ccc1CCNS(=O)(=O)c1cc(C#N)ccc1OC>>CCOC(=O)COc1cc(C(C)C)ccc1CCNS(=O)(=O)c1cc(C#N)ccc1O,,CN(C)C=O,,[Cl-].[Li+],,val
US20140038919A1,COc1ccc(-c2nn3ccc(Br)cc3c2-c2noc(=O)[nH]2)cc1.ClCCBr>>COc1ccc(-c2nn3ccc(Br)cc3c2-c2noc(=O)n2CCCl)cc1,,CC(=O)N(C)C,,C1CCC2=NCCCN2CC1,,val
US20070037868A1,C=CCO[C@@H]1C[C@H](NC[C@@H](O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC=C)N2CC[C@H](CC(C)C)C2=O)c2cc(OC)ccc21>>COc1ccc2c(c1)[C@@H]1C[C@H]2OCC=CC[C@H](N2CC[C@H](CC(C)C)C2=O)C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CN1,,ClCCl,,,,val
US20160158207A1,CC(=O)N1CCc2c(c(Nc3cccc(Br)c3)nn2CC2CC2)C1.CCCC[Sn](CCCC)(CCCC)c1ccccn1>>CC(=O)N1CCc2c(c(Nc3cccc(-c4ccccn4)c3)nn2CC2CC2)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O,,val
US20070105904A1,Fc1ccccn1.OCc1ccc(C2OCCO2)c(F)c1>>Fc1cc(COc2ccccn2)ccc1C1OCCO1,,CN(C)C=O,,[H-].[Na+],,val
US20050032787A1,CS(=O)(=O)OCCn1ccc2ccccc21.O=Cc1ccc(O)cc1>>O=Cc1ccc(OCCn2ccc3ccccc32)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20020132796A1,CCCNC1(c2ccc(C#C[Si](C)(C)C)cc2)CC1>>C#Cc1ccc(C2(NCCC)CC2)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20100261698A1,CCN(CC)S(=O)(=O)Oc1cncc(-c2cc3ccc(Cl)cc3[nH]2)c1.COC(=O)OC>>CCN(CC)S(=O)(=O)Oc1cncc(-c2cc3ccc(Cl)cc3n2C)c1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20060014816A1,CN1CCN(C(=O)c2cc([N+](=O)[O-])c3c(c2)C2(CC3)OCCO2)CC1>>CN1CCN(C(=O)c2cc(N)c3c(c2)C2(CC3)OCCO2)CC1,[Ni],CCO,,,,val
US20130102586A1,COc1ccc(Cn2nc(C)c3cc(Nc4ccc(N5CCN(C)CC5)c(F)c4)cnc32)cc1>>Cc1n[nH]c2ncc(Nc3ccc(N4CCN(C)CC4)c(F)c3)cc12,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20100093727A1,Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C.O=S(=O)([O-])CC1COC2(CC2)C1>>Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC5COC6(CC6)C5)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C,,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100048646A1,Fc1cc(CCl)cnc1Cl.NCC(F)F>>Fc1cc(CNCC(F)F)cnc1Cl,,CC#N,,CCN(CC)CC,,val
US05516774,Cc1ccsc1C(=O)Cl.Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1>>Cc1ccsc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1,,ClCCl,,CCN(CC)CC,,val
US20100099728A1,CN(C)CCOc1ccc2c(c1)OCC21C(=O)N(C(c2ccccc2)c2ccccc2)c2ccccc21>>CN(C)CCOc1ccc2c(c1)OCC21C(=O)Nc2ccccc21,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20120208817A1,CCOc1cc(C=O)cc([N+](=O)[O-])c1O.N#Cc1cccc(C(=O)Cc2ccccc2)c1.NC(N)=O>>CCOc1cc(C2NC(=O)NC(c3cccc(C#N)c3)=C2c2ccccc2)cc([N+](=O)[O-])c1O,,CCO,,Cl,,val
US20030199553A1,CCOC(=O)CBr.O=[N+]([O-])c1ccc2c(c1)NCCCO2>>CCOC(=O)CN1CCCOc2ccc([N+](=O)[O-])cc21,,CN(C)C=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20030225131A1,COCn1ccc(=O)c([N+](=O)[O-])c1Cl.NCC(F)(F)c1ccccn1>>COCn1ccc(=O)c([N+](=O)[O-])c1NCC(F)(F)c1ccccn1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20100016340A1,CC(C)(C)OC(=O)N1CCC(C#N)(c2ccc(OC(F)(F)F)cc2)CC1>>CC(C)(C)OC(=O)N1CCC(CN)(c2ccc(OC(F)(F)F)cc2)CC1,[Ni],CCO,,[H][H],,val
US20090247746A1,CCOC(=O)C(=O)CBr.Cc1ccc(N(C)S(=O)(=O)c2cccs2)c2[nH]c(C(N)=S)cc12>>CCOC(=O)c1csc(-c2cc3c(C)ccc(N(C)S(=O)(=O)c4cccs4)c3[nH]2)n1,,CCOC(C)=O,,CC(=O)N(C)C,,val
US20140243310A1,O=C(O)c1cc(F)c(F)c(F)c1.OCc1ccccc1>>O=C(O)c1cc(F)c(OCc2ccccc2)c(F)c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US04377580,COC(=O)c1cnc2c3cc(NC(=O)C4CCCCC4)ccc3ncn2c1=O>>O=C(O)c1cnc2c3cc(NC(=O)C4CCCCC4)ccc3ncn2c1=O,,c1ccncc1,,[I-].[Li+],,val
US20160272578A1,CCCCCCCC/C=C\CCCCCC/C=C1/OC(=O)C1CCCCCC/C=C\CCCCCCCC.NC(CO)CO>>CCCCCCCC/C=C\CCCCCCCC(=O)C(CCCCCC/C=C\CCCCCCCC)C(=O)NC(CO)CO,,CCO,,,,val
US05120874,BrCc1ccccc1.O=C(c1ccccc1)C(O)Cc1cccc(O)c1>>O=C(c1ccccc1)C(O)Cc1cccc(OCc2ccccc2)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20060173039A1,COc1ncc(-c2ccc(CN(C)C)cc2)c2c(O)cccc12>>CN(C)Cc1ccc(-c2c[nH]c(=O)c3cccc(O)c23)cc1,,CC(=O)O,,Br,O,val
US20130203727A1,CCOC(=O)C(O)c1c(C)cc2cc(Cl)c(F)cc2c1OS(=O)(=O)C(F)(F)F>>CCOC(=O)C(=O)c1c(C)cc2cc(Cl)c(F)cc2c1OS(=O)(=O)C(F)(F)F,,CCOCC,ClCCl,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20120041040A1,C#CC(C)(C)O.CN(C)CCCl.[N-]=[N+]=[N-]>>CN(C)CCn1nncc1C(C)(C)O,,O,,Cl,,val
US20100121048A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1CCCNC1O>>CC(C)(C)OC(=O)NC1CCCNC1=O,,CO,,CCN(CC)CC,CN(C)C=O,val
US20040006099A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc(OCC(=O)O)cc2)C1.N#Cc1ccc(NCCO)c(N)c1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(OCC(=O)Nc3cc(C#N)ccc3NCCO)cc2)C1,,ClC(Cl)Cl,,,,val
US20160221994A1,CC(=O)c1ccc(-c2cc(Cl)c3c(c2)CC(CN)O3)s1.CCN=C=NCCCN(C)C.CN(C)C=O.ClCCl.On1nnc2ccccc21>>CC(=O)c1ccc(-c2cc(Cl)c3c(c2)CC(CNC(=O)/C=C/c2cnc(N)nc2)O3)s1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20150291573A1,CC1(S(=O)(=O)c2cccc(C(F)(F)F)c2)CCOC(c2cc(Br)ccc2Br)C1.N#C[Cu]>>CC1(S(=O)(=O)c2cccc(C(F)(F)F)c2)CCOC(c2cc(Br)ccc2C#N)C1,,CN(C)C=O,,,,val
US20150284394A1,CN(Cc1ccc(B2OC(C)(C)C(C)(C)O2)cc1F)C(=O)OC(C)(C)C.Cn1cc(-c2cc3c(Cl)ncnc3n2S(=O)(=O)c2ccccc2)cn1>>CN(Cc1ccc(-c2ncnc3[nH]c(-c4cnn(C)c4)cc23)cc1F)C(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,O,COCCOC,O=C([O-])[O-].[K+].[K+],val
US20050070541A1,CCCc1nc(CC)c2c(=O)[nH]c(-c3cc(S(=O)(=O)Cl)ccc3OCC)nn12.COCCN>>CCCc1nc(CC)c2c(=O)[nH]c(-c3cc(S(=O)(=O)NCCOC)ccc3OCC)nn12,,C1CCCCC1,CCOC(C)=O,,,val
US20090226398A1,COc1cc(Br)ccc1C=O.COc1ccc(B(O)O)c(C(F)(F)F)c1>>COc1ccc(-c2ccc(C=O)c(OC)c2)c(C(F)(F)F)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20050277772A1,COc1ccc2ccc(O)c(-c3nnc(Cl)c4ccccc34)c2c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc2ccc(OS(=O)(=O)C(F)(F)F)c(-c3nnc(Cl)c4ccccc34)c2c1,,ClCCl,,c1ccncc1,,val
US20100298293A1,CC(C)c1cc([N+](=O)[O-])ccc1F.O=C1NCCCN1>>CC(C)c1cc([N+](=O)[O-])ccc1N1CCCNC1=O,,CS(C)=O,O,CC(C)(C)[O-].[K+],,val
US05599829,CCI.Cc1ccc(Cl)cc1NC(=S)NCC(N)=O>>CCSC1=NCC(=O)N1c1cc(Cl)ccc1C,,CCO,,,,val
US20130059883A1,N#CCC#N.[N-]=[N+]=CC(=O)c1ccccc1>>N#CCc1ncc(-c2ccccc2)o1,,ClCCl,,CCOCC,FB(F)F,val
US05849735,Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Cl)cn1.c1ccc2c(c1)Cc1ccsc1CN2>>Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3sccc3Cc3ccccc32)cn1,,ClCCl,,CCN(CC)CC,,val
US20140228405A1,Cc1cc([C@@H]2C[C@H]2N)ccc1NC(=O)c1ccccc1.Cl.O=CC1CC1>>Cc1cc([C@@H]2C[C@H]2NCC2CC2)ccc1NC(=O)c1ccccc1.Cl,,C1CCOC1,CO,[BH4-].[Na+],,val
US20160137649A1,CCOC(=O)/C(CC(C)=O)=N/OC.NNC1CCCCC1>>CCOC(=O)c1cc(C)nn1C1CCCCC1,,CCO,,Cl,,val
US20050107449A1,COC(=O)C=Cc1ccc([N+](=O)[O-])cc1C>>COC(=O)CCc1ccc(N)cc1C,[Pd],CO,,[H][H],,val
US20150258074A1,Cc1nc(Cl)cc2[nH][nH]c(=O)c12.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cc1nc(Cl)cc2c1c(=O)[nH]n2C(c1ccccc1)(c1ccccc1)c1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US06821993B1,O=S(Cl)Cl.OCCCc1cccnc1>>Cl.ClCCCc1cccnc1,,ClC(Cl)Cl,,,,val
US05260316,BrP(Br)Br.OCc1ccc(-c2ccc(F)cc2)cc1>>Fc1ccc(-c2ccc(CBr)cc2)cc1,,CCOCC,O,,,val
US20040010141A1,CCOC(=O)C1(C(=O)OCC)CCCN1c1ccc(Oc2ccc3c(cnn3-c3cccnc3)c2)nc1.NC(N)=O>>O=C1NC(=O)C2(CCCN2c2ccc(Oc3ccc4c(cnn4-c4cccnc4)c3)nc2)C(=O)N1,,CCO,,[Na],,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccncc4)nc(Cl)c3n2)cc1.Nc1ccc2[nH]ncc2c1>>c1cc(-c2nc(Nc3ccc4[nH]ncc4c3)c3[nH]ncc3n2)ccn1,C1COCCO1,CO,,Cl,,val
US20120040954A1,CC(=O)Cl.COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCC(N)C4)cc3)nc2c1>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCC(NC(C)=O)C4)cc3)nc2c1,,ClCCl,,CCN(CC)CC,,val
US20040122244A1,COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)N3CCCCC3)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(O)c(C(=O)N3CCCCC3)c2)=C(C)C1=O,,CO,O,O=C([O-])O.[Na+],,val
US20050233988A1,BrBr.CC(=O)OC[C@H]1O[C@@H](c2ccc(C)c(Cc3cccs3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(=O)OC[C@H]1O[C@@H](c2ccc(C)c(Cc3ccc(Br)s3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,ClC(Cl)Cl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US20080312231A1,COC(=O)CC1CCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1>>O=C(O)CC1CCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1,,CO,O,[Li+].[OH-],,val
US20140242606A1,CC(C)(C)OC(=O)C[C@H](N)C(=O)O.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)O,,C1CCOC1,O,O=C([O-])O.[Na+],,val
US20070149583A1,Br.COC(=O)c1nc([C@@H](NC(=O)OCc2ccccc2)C(C)C)oc1-c1c[nH]c2c(Br)cccc12>>Br.COC(=O)c1nc([C@@H](N)C(C)C)oc1-c1c[nH]c2c(Br)cccc12,,CC(=O)O,,COC(C)(C)C,,val
US20100239526A1,COc1ccc(Cn2nccc2N)cc1.Cc1nc2c(s1)C(=O)/C(=C\N(C)C)CC2>>COc1ccc(Cn2ncc3c4c(cnc32)CCc2nc(C)sc2-4)cc1,,O,,O=C(O)C(F)(F)F,,val
US20130116234A1,C1CCNCC1.COC(=O)c1c(Cl)nc2c(Cl)cc(Cl)cc2c1-c1ccccc1>>O=C(O)c1c(N2CCCCC2)nc2c(Cl)cc(Cl)cc2c1-c1ccccc1,,c1ccncc1,,O,,val
US05880188,O=Cc1ccccc1B(O)O.[C-]#N>>N#CC1OB(O)c2ccccc21,,O,,Cl,,val
US04567172,CC(=O)O[C@]1(C(=O)CO)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C.CCC(=O)OC(=O)CC>>CCC(=O)OCC(=O)[C@@]1(OC(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C,,ClCCl,,c1ccncc1,,val
US20110294776A1,CS(=O)(=O)Cl.Nc1ncnn2c(C3CCNCC3)cc(-c3ccc4cn(-c5ccccc5)nc4c3)c12>>CS(=O)(=O)N1CCC(c2cc(-c3ccc4cn(-c5ccccc5)nc4c3)c3c(N)ncnn23)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20130059834A1,CC(NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)[C@@H]1C[C@H](C#N)C1>>CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)[C@@H]1C[C@H](C#N)C1,,ClCCl,,NCCN,O=C(O)C(F)(F)F,val
US20110218197A1,Cn1nc(C(C)(C)C)cc1C(=O)N(C(=O)c1cc(C(C)(C)C)nn1C)c1nc(-c2ccccc2C(F)(F)F)ccc1[N+](=O)[O-]>>Cn1nc(C(C)(C)C)cc1-c1nc2nc(-c3ccccc3C(F)(F)F)ccc2[nH]1,[Fe],CC(=O)O,,,,val
US04977272,C=CCBr.CC(=NO)c1ccc(NC(=O)NCC(=O)Oc2ccccc2)cc1>>C=CCON=C(C)c1ccc(NC(=O)NCC(=O)Oc2ccccc2)cc1,,O,,C[O-].[Na+],,val
US20160075686A1,CC(C)(C)OC(=O)N1CCC(O)(c2cncc(Br)c2)C1.CCN(CC)S(F)(F)F>>CC(C)(C)OC(=O)N1CCC(F)(c2cncc(Br)c2)C1,,ClCCl,,O=C([O-])O.[Na+],,val
US20160207926A1,CC(C)(C)OC(=O)N[C@H]1CCN(C(=O)C2CC2)C1.CI>>CN(C(=O)OC(C)(C)C)[C@H]1CCN(C(=O)C2CC2)C1,,CN(C)C=O,,[H-].[Na+],,val
US20030207882A1,O=C(O)c1ccc(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)cc1.c1cc(N2CCNCC2)ccn1>>O=C(c1ccc(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)cc1)N1CCN(c2ccncc2)CC1,,CN(C)C=O,,O=C(n1ccnc1)n1ccnc1,,val
US05395937,CC(C)CN.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=[N+]([O-])c1c(O)nc2ccccc2c1O>>CC(C)CNc1c([N+](=O)[O-])c(OS(=O)(=O)C(F)(F)F)nc2ccccc12,,ClCCl,,CCN(CC)CC,,val
US20090291950A1,COc1ccc2c(c1OC1CCCC1)OCC2=O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc2c(OS(=O)(=O)C(F)(F)F)coc2c1OC1CCCC1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20140113882A1,COc1cncc2nc(-c3ccnc(Nc4ccccc4)c3)nc(N3CCN(C(=O)OC(C)(C)C)CC3)c12>>COc1cncc2nc(-c3ccnc(Nc4ccccc4)c3)nc(N3CCNCC3)c12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110124634A1,CCN(CC)CCN.Nc1nc(Cl)c2c(n1)N(Cc1ccccn1)C(=O)/C2=C\c1cc(C(=O)O)c[nH]1>>CCN(CC)CCNC(=O)c1c[nH]c(/C=C2\C(=O)N(Cc3ccccn3)c3nc(N)nc(Cl)c32)c1,,C1CCOC1,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US04871743,CCOC(=O)CC[C@H](NC(=O)c1ccc(CCCCc2c(N)nc(N)nc2O)cc1)C(=O)OCC>>Nc1nc(N)c(CCCCc2ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc2)c(O)n1,,[Na+],[OH-],Cl,,val
US20050171180A1,CCC(CC)C(NS(=O)(=O)c1ccc(Cl)s1)c1ccnn1Cc1ccc(OC)cc1>>CCC(CC)C(NS(=O)(=O)c1ccc(Cl)s1)c1ccnn1Cc1ccc(O)cc1,,ClCCl,,BrB(Br)Br,O,val
US20110028487A1,N#CCc1ccc(Cl)c(F)c1.O=S(=O)(O)O>>O=C(O)Cc1ccc(Cl)c(F)c1,,CC(=O)O,,O,,val
US20110053931A1,Cn1c(Cl)ccc(-c2ccc(OCc3ccccc3)c(F)c2)c1=O.Nc1ccccc1>>Cn1c(Nc2ccccc2)ccc(-c2ccc(OCc3ccccc3)c(F)c2)c1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100249139A1,COC(=O)C(C(=O)c1ccnc(C)c1)c1ccc(OC)cc1Cl>>COc1ccc(CC(=O)c2ccnc(C)c2)c(Cl)c1,,CS(C)=O,,O,[Cl-].[Na+],val
US20100120739A1,Nc1ccc(Br)cc1F.O=[N+]([O-])c1ccccc1>>Fc1cc(Br)cc2cccnc12,,OCC(O)CO,,O=S(=O)(O)O,,val
US20120214791A1,Cc1ccc(Br)cc1.Cn1nccc1B(O)O>>Cc1ccc(-c2ccnn2C)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20140045823A1,CC(C)(C)OC(=O)N1CCC(N(C(=O)c2cnc(Cl)nc2)C2CC2)CC1.c1cn[nH]c1>>CC(C)(C)OC(=O)N1CCC(N(C(=O)c2cnc(-n3cccn3)nc2)C2CC2)CC1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US06137003,C1CO1.CC(=O)O.CCCCCCCCOc1cc(C(=O)OC)ccc1N>>CCCCCCCCOc1cc(C(=O)OC)ccc1N(CCO)CCO,,O,,,,val
US06645976B1,COC(=O)COc1cccn2c(Cc3ccccc3-c3ccccc3)c(C(C)C)c(C(=O)C(N)=O)c12>>Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1ccccc1-c1ccccc1,,ClC(Cl)Cl,,,,val
US20160046624A1,Cn1c(=O)n(CCCOC2CCCCO2)c(=O)c2c(C(O)c3ccc(Cl)cc3)c(Br)cnc21.O=CO>>Cn1c(=O)n(CCCOC=O)c(=O)c2c(Cc3ccc(Cl)cc3)c(Br)cnc21,[Zn],O=CO,,,,val
US20160166560A1,CN(C(=O)n1cnc(-c2cccc(N)c2)c1)C1CCN(Cc2ccccc2)CC1.NS(=O)(=O)Cl>>CN(C(=O)n1cnc(-c2cccc(NS(N)(=O)=O)c2)c1)C1CCN(Cc2ccccc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120329830A1,COc1ccc(CNc2nc3ccc(Br)cc3nc2CCC(=O)O)cc1.NCC1CCCCC1>>COc1ccc(CNc2nc3ccc(Br)cc3nc2CCC(=O)NCC2CCCCC2)cc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090137557A1,Cc1nc(-c2cccc(F)c2OCc2ccccc2)n(CCc2ccccc2)c(=O)c1-c1ccc(Cl)s1>>Cc1nc(-c2cccc(F)c2O)n(CCc2ccccc2)c(=O)c1-c1ccc(Cl)s1,,CC(=O)O,ClCCl,Br,,val
US20140275021A1,CN(C)CCOc1ccn2nc(N)c(C(=O)O)c2n1.Cc1ccncc1N>>Cc1ccncc1NC(=O)c1c(N)nn2ccc(OCCN(C)C)nc12,,CN1CCCC1=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20130089625A1,CC(C)S(=O)(=O)c1ccc(-c2cnc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(-c3cc(-c4ccc(CN(C(=O)OC(C)(C)C)C5CCOCC5)cc4)no3)n2)cc1>>CC(C)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3cc(-c4ccc(CNC5CCOCC5)cc4)no3)n2)cc1,,CCO,ClCCl,O=C(O)C(F)(F)F,[Na+].[OH-],val
US20050222118A1,CC(Cl)OC(=O)Cl.Clc1ccc(OC2CN(C(c3ccccc3)c3ccccc3)C2)cc1Cl>>Cl.Clc1ccc(OC2CNC2)cc1Cl,,ClCCl,,,,val
US20140094465A1,COC(=O)c1ccc(CC(=O)c2ccc(O)cc2F)c(F)c1>>O=C(O)c1ccc(CC(=O)c2ccc(O)cc2F)c(F)c1,,CO,,[Na+].[OH-],,val
US20130012554A1,CS(=O)(=O)Cl.O=C1O[C@@H](CO)CN1c1ccc(N2CC3CC4(CC3C2)OCCO4)c(F)c1>>CS(=O)(=O)OC[C@H]1CN(c2ccc(N3CC4CC5(CC4C3)OCCO5)c(F)c2)C(=O)O1,,ClCCl,,CCN(CC)CC,,val
US20120270857A1,COC(=O)c1cccc(N)c1NCC(OC)OC.O=C(c1ncc[nH]1)c1ncc[nH]1>>COC(=O)c1cccc2[nH]c(=O)n(CC(OC)OC)c12,,C1CCOC1,,,,val
US20100160308A1,CS(=O)(=O)Cl.O=Cc1cc(F)ccc1O>>CS(=O)(=O)Oc1ccc(F)cc1C=O,,ClCCl,,CCN(CC)CC,,val
US20020042414A1,COc1cc(/C=C/C=C/C(=O)N2CCN(C(=O)/C=C/C=C/c3cc(OC)c(OC)c(OC)c3)C(CN3C(=O)c4ccccc4C3=O)C2)cc(OC)c1OC>>COc1cc(/C=C/C=C/C(=O)N2CCN(C(=O)/C=C/C=C/c3cc(OC)c(OC)c(OC)c3)C(CN)C2)cc(OC)c1OC,,CO,,NN,O,val
US20070021606A1,Br[Mg]c1ccccc1.CON(C)C(=O)COCc1cc(S(=O)(=O)N2CCCCC2)ccc1Cl>>O=C(COCc1cc(S(=O)(=O)N2CCCCC2)ccc1Cl)c1ccccc1,,C1CCOC1,,,,val
US20040034015A1,Fc1ccc(S)cc1.O=C1CCO1>>O=C(O)CCSc1ccc(F)cc1,,C1CCOC1,,[H-].[Na+],,val
US20150291514A1,COC(=O)c1cc(F)c(F)cc1F.COc1cccc(O)c1>>COC(=O)c1cc(F)c(Oc2cccc(OC)c2)cc1F,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20060293340A1,Cc1ccc(N)cc1Nc1nccc(-c2cnccn2)n1.O=C(O)c1cccc(SC(F)(F)F)c1>>Cc1ccc(NC(=O)c2cccc(SC(F)(F)F)c2)cc1Nc1nccc(-c2cnccn2)n1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20120252853A1,Cc1cc2[nH]ccc2cc1C#N>>Cc1cc2[nH]ccc2cc1CN,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080167302A1,C1COOOC1.C=CCCCCCC(=O)N1C(=O)OC[C@@H]1Cc1ccccc1.ClCCl>>C=CCCCC[C@H](CO)C(=O)N1C(=O)OC[C@@H]1Cc1ccccc1,Cl[Ti](Cl)(Cl)Cl,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060149062A1,CS(=O)(=O)c1ccc(I)c(C(=O)O)c1.N#Cc1ccc(N2CCNCC2)cc1>>CS(=O)(=O)c1ccc(I)c(C(=O)N2CCN(c3ccc(C#N)cc3)CC2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US05650428,CCC[C@H](NS(=O)(=O)c1ccc(Cl)cc1)C(=S)Nc1ccc(CC(=O)OCC)cc1>>CCC[C@H](NS(=O)(=O)c1ccc(Cl)cc1)C(=S)Nc1ccc(CC(=O)O)cc1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US07320993B1,O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C(c2ccccc2)C1>>NCCCCN1CCc2ccccc2C(c2ccccc2)C1,,CCO,,NN,O,val
US05658922,CI.C[C@H]1C[C@H]2N(C)C(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3C(C)(C)O)[C@H]12>>COC(C)(C)[C@H]1CC[C@H]2[C@@H]3[C@@H](C)C[C@H]4N(C)C(=O)CC[C@]4(C)[C@H]3CC[C@@]21C,,CN(C)C=O,O,[H-].[Na+],[Cl-].[NH4+],val
US20020193402A1,COCCOCn1nnnc1[C@]1(F)C[C@@]2(c3ccccc3)[C@H](O[C@@H](CI)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC[C@@H]1N2Cc1ccccc1>>C[C@H](O[C@@H]1CC[C@@H]2N(Cc3ccccc3)[C@@]1(c1ccccc1)C[C@@]2(F)c1nnn[nH]1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,[Pd],CCOC(C)=O,CO,CCN(CC)CC,,val
US04435391,CCOC(=O)c1ccc(Oc2cccc(OC)c2)c(NC(C)=O)c1.O=P(Cl)(Cl)Cl>>CCOC(=O)c1ccc2c(c1)N=C(C)c1ccc(OC)cc1O2.Cl,,Cc1ccccc1,,,,val
US20120010182A1,OB(O)c1ccccc1F.Oc1ccc(Br)c(Cl)c1>>Oc1ccc(-c2ccccc2F)c(Cl)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040138462A1,CC(C)(Cc1ccc(S(=O)(=O)c2cccc(C(=O)O)c2)cc1)NC(=O)C(F)(F)F>>CC(C)(N)Cc1ccc(S(=O)(=O)c2cccc(C(=O)O)c2)cc1,,CCO,,[Na+].[OH-],,val
US04072696,COC(=O)N=C=S.NC(=O)Sc1ccc(N)c([N+](=O)[O-])c1>>COC(=O)NC(=S)Nc1ccc(SC(N)=O)cc1[N+](=O)[O-],,CC(C)=O,,,,val
US05892039,CC(C)(C)OC(=O)NCC(=O)O.Cc1cc(C)cc(C(=O)N2CCNC(c3ccc(Cl)c(Cl)c3)C2)c1>>Cc1cc(C)cc(C(=O)N2CCNC(c3ccc(Cl)c(Cl)c3)C2)c1.N,,ClCCl,,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US20070037802A1,O=[N+]([O-])c1ccccc1O.OCCCl>>O=[N+]([O-])c1ccccc1OCCCl,,C1CCOC1,O,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20130217658A1,Fc1cccc(C(F)(F)F)c1CBr.O=[N+]([O-])c1cn[nH]c1>>O=[N+]([O-])c1cnn(Cc2c(F)cccc2C(F)(F)F)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080207728A1,N[C@@H](CO)Cc1c[nH]c2ccccc12.O=C(O)c1cc(Br)cc2c1OCCO2>>O=C(N[C@@H](CO)Cc1c[nH]c2ccccc12)c1cc(Br)cc2c1OCCO2,,CN(C)C=O,,ClCCCl,On1nnc2ccccc21,val
US20120029002A1,Nc1nc(-n2nc(Sc3ccccc3F)c3ccccc32)nc(N)c1[N+](=O)[O-]>>Nc1nc(-n2nc(Sc3ccccc3F)c3ccccc32)nc(N)c1N,[Pd],c1ccncc1,,,,val
US20030187053A1,CCOC(=O)c1cc2cc([N+](=O)[O-])ccc2[nH]1.COS(=O)(=O)c1ccc(C)cc1>>CCOC(=O)c1cc2cc([N+](=O)[O-])ccc2n1C,,CC#N,,O,O=C([O-])[O-].[K+].[K+],val
US20090137561A1,COc1ccc(F)c(-c2ccc(C=O)cc2OC(F)(F)F)c1>>COc1ccc(F)c(-c2ccc(CO)cc2OC(F)(F)F)c1,,CO,,[BH4-].[Na+],,val
US20060211861A1,CN(C)C=O.Cc1cc(C(=O)O)cc(C)c1Br>>Cc1cc(C(=O)O)cc(C)c1C=O,,C1CCOC1,,Cl,[Li]CCCC,val
US20050171103A1,CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Clc1ncc(Br)cn1>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(-c2cnc(Cl)nc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])O.[Na+],,val
US20060270750A1,C=C(C)C(=O)Cl.Nc1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I>>C=C(C)C(=O)Nc1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I,,CCOC(C)=O,c1ccncc1,,,val
US20080214529A1,COC(=O)C1CCCN1NCCC(C)C.CS(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(CC(=O)O)N2>>COC(=O)C1CCCN1N(CCC(C)C)C(=O)CC1=NS(=O)(=O)c2cc(NS(C)(=O)=O)ccc2N1,,CN(C)C=O,ClCCl,,,val
US20060030612A1,CCOC(=O)c1cccc(C#Cc2cccc(-c3c4cccc(C(F)(F)F)c4nn3Cc3c(F)cc(F)cc3F)c2)c1>>O=C(O)c1cccc(C#Cc2cccc(-c3c4cccc(C(F)(F)F)c4nn3Cc3c(F)cc(F)cc3F)c2)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US06194410B1,CSc1nn2c(Cl)c3c(nc2c1S(=O)(=O)c1ccccc1)CCC3.N>>CSc1nn2c(N)c3c(nc2c1S(=O)(=O)c1ccccc1)CCC3,,CO,,,,val
US20010039279A1,COc1cc(/C=C/C=C/C(=O)O)cc(OC)c1OC.O=C(Cl)C(=O)Cl>>COc1cc(/C=C/C=C/C(=O)Cl)cc(OC)c1OC,,CN(C)C=O,ClCCl,,,val
US20050176701A1,O=C(O)CCC1CCCCC1.c1ccc(SSc2ccccn2)nc1>>O=C(CCC1CCCCC1)Sc1ccccn1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04772600,OC(Cn1c(-c2ccc(Cl)cc2)nc2cccnc21)c1ccccc1>>O=C(Cn1c(-c2ccc(Cl)cc2)nc2cccnc21)c1ccccc1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20090118535A1,CCCCOC(=S)[C@@H](O)[C@@H](C)c1ccccc1.CCO>>CCCCOC(=O)[C@@H](O)CC,[Ni],,,,,val
US20140206673A1,CC(C)(C)OC(=O)NC(CC(F)(F)F)C(=O)O.COC(=O)CN>>COC(=O)CNC(=O)C(CC(F)(F)F)NC(=O)OC(C)(C)C,,ClCCl,,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20160002224A1,CC(=O)OCC1(c2ccc(-c3cc4cc(Cc5ccc(C)c(C(=O)O)c5)[nH]c4cc3Cl)cc2)CC1>>Cc1ccc(Cc2cc3cc(-c4ccc(C5(CO)CC5)cc4)c(Cl)cc3[nH]2)cc1C(=O)O,,CO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20080090794A1,C1COCCN1.COC(=O)C(Br)c1ccccc1>>COC(=O)C(c1ccccc1)N1CCOCC1,,CC#N,,CCN(CC)CC,O,val
US20060264440A1,CC1(C)OC(=O)C(=CNc2ccc(I)cn2)C(=O)O1>>O=c1ccnc2ccc(I)cn12,,c1ccc(Oc2ccccc2)cc1,,,,val
US20150335626A1,Cn1cc(OCc2ccccc2)c(=O)cc1C(O)(O)C(F)(F)F>>Cn1cc(O)c(=O)cc1C(O)(O)C(F)(F)F,,O,,Cl,[Na+].[OH-],val
US05519133,COC(=O)CNC(=O)Nc1cc(F)ccc1[N+](=O)[O-].O=C=NC(=O)Cl>>COC(=O)Cn1c(=O)[nH]c(=O)n(-c2cc(F)ccc2[N+](=O)[O-])c1=O,,ClCCl,,c1ccncc1,,val
US20160016948A1,CC(C)Br.Clc1cc2[nH]ccc2cn1>>CC(C)n1ccc2cnc(Cl)cc21,,CN(C)C=O,,[H-].[Na+],,val
US20160207926A1,O=c1ccc([N+](=O)[O-])cn1CC1CC1>>NC1CCC(=O)N(CC2CC2)C1,[Pd],CO,,,,val
US20100311593A1,COC(=O)Cc1c(C)cc(Br)cc1C.OCC(F)(F)F>>Cc1cc(OCC(F)(F)F)cc(C)c1CC(=O)O,[Cu]I,CN(C)C=O,,[H-].[Na+],,val
US05026858,CC(=O)Nc1cc(OC(C)=O)c(C(=O)NC2CCN(Cc3ccccc3)CC2)cc1[N+](=O)[O-].Cl>>Cl.Nc1cc(O)c(C(=O)NC2CCN(Cc3ccccc3)CC2)cc1[N+](=O)[O-],,CCO,O,O=C([O-])O.[Na+],,val
US20070200490A1,Cn1c(-c2ccccc2)nc2cc(Br)ccc21.OB(O)c1ccc(Cl)cc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Clc1ccc(-c2ccc3c(c2)nc(-c2ccccc2)n3-c2ccccc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20100305096A1,CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1.CN(C)C(=O)C1CNC1>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CC(C(=O)N(C)C)C3)n(C)c2n1,,ClCCCl,,Cl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20150299181A1,Cc1c(C#N)oc2cc(CO)ccc12>>Cc1c(C#N)oc2cc(C=O)ccc12,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US20100190768A1,BrCc1ccccc1.O=C(OCCO)C(O)(c1cn(Cc2ccccc2)c2cc([N+](=O)[O-])ccc12)C(F)(F)F>>O=C(OCCOCc1ccccc1)C(O)(c1cn(Cc2ccccc2)c2cc([N+](=O)[O-])ccc12)C(F)(F)F,,CN(C)C=O,,[H-].[Na+],[Cl-].[NH4+],val
US20080139546A1,Nc1cccc(F)c1.O=C(Cl)CCCl>>O=C1CCc2ccc(F)cc2N1,,CC(C)=O,O,c1ccncc1,,val
US04844835,C[C@@H](Cl)CO.O=C(OCc1ccccc1)Oc1ccc(-c2ccc(C(=O)Cl)cc2)cc1>>CC(Cl)COC(=O)c1ccc(-c2ccc(OC(=O)OCc3ccccc3)cc2)cc1,,CCOCC,,C1CCOC1,CCN(CC)CC,val
US20040077642A1,Brc1cn[nH]c1.CON(C)C(=O)c1ccc(Br)cc1>>O=C(c1ccc(Br)cc1)c1cn[nH]c1,,CCOC(C)=O,,[Li]C(C)(C)C,,val
US20140323376A1,CC(=O)C(=O)O.CC(C)=CCC/C(C)=C/CO>>CC(=O)C(=O)OC/C=C(\C)CCC=C(C)C,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US05389658,CCCCCCCC(=O)NCCCCO.CS(=O)(=O)Cl>>CCCCCCCC(=O)NCCCCOS(C)(=O)=O,,ClCCl,,CCN(CC)CC,,val
US04770689,COC(=O)CCl.NC(c1ccccc1)c1ccccn1>>CN(CC(=O)O)C(c1ccccc1)c1ccccn1,,O,,CCN(CC)CC,CN(C)C=O,val
US20160002188A1,CC(C)(C)OC(=O)Nc1cc(-c2cccc(-c3ccc(C(=O)N4CCNCC4)cc3)c2)n[nH]1.O=C(O)C1(O)CC1>>CC(C)(C)OC(=O)Nc1cc(-c2cccc(-c3ccc(C(=O)N4CCN(C(=O)C5(O)CC5)CC4)cc3)c2)n[nH]1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110218193A1,CI.COc1ccc(Cn2c(=O)c3c(c4cc(OC)ccc42)NCCC3)cc1>>COc1ccc(Cn2c(=O)c3c(c4cc(OC)ccc42)N(C)CCC3)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20080293749A1,NCc1ccccc1N.O=C1C=CC(=O)N1>>Nc1ccccc1CNC1CC(=O)NC1=O,,CCOC(C)=O,,,,val
US20030199550A1,CN(C[C@@H]1CC[C@@H](COCCCCBr)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1.OC[C@@H]1CCCN1>>CN(C[C@@H]1CC[C@@H](COCCCCN2CCC[C@H]2CO)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1,,CC(=O)N(C)C,,,,val
US20070066573A1,CCOC(=O)c1c(-c2ccc(O)cc2)c(C#N)c(CC)n1C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)c1c(-c2ccc(OS(=O)(=O)C(F)(F)F)cc2)c(C#N)c(CC)n1C,,CCOC(C)=O,ClCCl,O,c1ccncc1,val
US20050143329A1,COC(=O)NN.O=Cc1c(Cl)n([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2cc(Cl)c(Cl)cc12>>COC(=O)NN=C=C1c2cc(Cl)c(Cl)cc2N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C1Cl,,CO,,O,,val
US20110301142A1,CCOC(=O)Cc1ccccc1O.Cc1noc(-c2ccc(CCl)cc2)c1NC(=O)OC(C)c1ccccc1Cl>>CCOC(=O)Cc1ccccc1OCc1ccc(-c2onc(C)c2NC(=O)OC(C)c2ccccc2Cl)cc1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20120214762A1,C#CC1(O)CCCCC1.COCCNc1nc2ccc(Br)cc2n1-c1ccnc(N)n1>>COCCNc1nc2ccc(C#CC3(O)CCCCC3)cc2n1-c1ccnc(N)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CS(C)=O,,CCN(CC)CC,,val
US20140005183A1,Cc1ccc(S(=O)(=O)n2cc(Br)c3c(N4CCC[C@H](C)C4)ncnc32)cc1.OCc1cccc(B(O)O)c1>>Cc1ccc(S(=O)(=O)n2cc(-c3cccc(CO)c3)c3c(N4CCC[C@H](C)C4)ncnc32)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CC#N,O,O=C([O-])[O-].[Na+].[Na+],,val
US20020045628A1,Fc1ccc2occc2c1>>Fc1ccc2c(c1)CCO2,[Pd],CC(=O)O,,,,val
US20050131017A1,Cc1ccc(-c2ccc(C[C@H]3[C@H](C[C@H](Cc4ccccc4)NC(=O)OC(C)(C)C)OC(C)(C)N3C(=O)OCc3ccccc3)cc2)nc1>>Cc1ccc(-c2ccc(C[C@H](NC(=O)OCc3ccccc3)[C@@H](O)C[C@@H](N)Cc3ccccc3)cc2)nc1,,C1CCOC1,,CO,Cl,val
US20080167341A1,CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)n1cccn1.NCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21>>CC(C)(C)OC(=O)NC(=NCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21)NC(=O)OC(C)(C)C,,C1CCOC1,,,,val
US20080027067A1,CC(C)(C)OC(=O)NC1CCN(c2ccc(S(=O)(=O)Nc3ncns3)cc2)CC1>>NC1CCN(c2ccc(S(=O)(=O)Nc3ncns3)cc2)CC1,,C1COCCO1,Cl,,,val
US20050054582A1,COC(=O)Cc1ccc(N)c(O)c1.Cc1ccccc1N=C=S>>COC(=O)Cc1ccc2nc(Nc3ccccc3C)oc2c1,,CCO,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20040006114A1,CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)cc1.OCc1cccnc1F>>CCS(=O)(=O)N(Cc1cccnc1F)c1ccc(Oc2ccc(F)cc2F)cc1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20010000511A1,CCOC(=O)Cc1ccc(Br)cc1>>O=CCc1ccc(Br)cc1,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US20070219230A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=[N+]([O-])c1cccnc1CNc1ccc(F)cc1>>CC(C)(C)OC(=O)N(Cc1ncccc1[N+](=O)[O-])c1ccc(F)cc1,,CCOCC,Cc1ccccc1,O=C([O-])O.[Na+],,val
US20140018326A1,CC(C)(C)OC(=O)N[C@H](CO)CS.O=c1[nH]ccc(Cl)c1[N+](=O)[O-]>>CC(C)(C)OC(=O)N[C@H](CO)CSc1cc[nH]c(=O)c1[N+](=O)[O-],,CCO,CCO,,,val
US05087737,C=C(C)C(N)=O.CC(C)(O)C(N)=O>>C=C(C)C#N.C=C(C)C(=O)O,,CC(C)=O,,CN1CCCC1=O,,val
US20100278733A1,CI.Nc1ccc(C=CC(=O)c2ccc(Br)s2)cc1>>CNc1ccc(C=CC(=O)c2ccc(Br)s2)cc1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US05234946,CCOC(=O)c1cccc(-n2cnnc2)c1>>OCc1cccc(-n2cnnc2)c1,,C1CCOC1,C1COCCO1,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20040192681A1,O=C(O)c1ccc(B(O)O)cc1.OCCCO>>O=C(O)c1ccc(B2OCCO2)cc1,,Cc1ccccc1,,,,val
US20080176829A1,C=O.CNCCO.Cc1cc(O)cc2cc[nH]c12>>Cc1cc(O)c(CN(C)CCO)c2cc[nH]c12,,CCO,ClCCl,,,val
US20150080369A1,CC(C)=O.CCc1ccc(N(CC(C)C)S(=O)(=O)c2ccc(C#C[Si](C)(C)C)c(C(=O)OC)c2)cc1>>CCc1ccc(N(CC(C)C)S(=O)(=O)c2ccc(C(C)=O)c(C(=O)OC)c2)cc1,,CC(C)=O,,O=S(=O)(O)O,,val
US09187441B2,CC(C)(C)NC(=O)C(c1c(C(=O)O)[nH]c2cc(Cl)ccc12)N(C=O)Cc1ccc(Cl)cc1>>CC(C)(C)NC(=O)C(NCc1ccc(Cl)cc1)c1c(C(=O)O)[nH]c2cc(Cl)ccc12,,O,,C1COCCO1,,val
US04167574,CCC(=O)N(c1ccccc1)C1(COC)CCNCC1.CCn1nnn(CCCl)c1=O.O>>CCC(=O)N(c1ccccc1)C1(COC)CCN(CCn2nnn(CC)c2=O)CC1.Cl.O,,CC(=O)CC(C)C,O,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20100286115A1,COC(=O)c1cc(O)nn1C.Cc1onc(-c2ccccn2)c1CO>>COC(=O)c1cc(OCc2c(-c3ccccn3)noc2C)nn1C,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20040204397A1,C=C(C(=O)OC)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.OC1CCNCC1>>COC(=O)C(CN1CCC(O)CC1)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,,CC#N,CCOC(C)=O,,,val
US20150322083A1,Cc1ccc2c(c1)Oc1sc(SC(C)C)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2.Cl>>Cc1ccc2c(c1)Oc1sc(SC(C)C)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2.Cl,,CC(C)=O,,,,val
US20150191469A1,Clc1nsc(Cl)n1.Cn1ncc2cc(B(O)O)ccc21>>Cn1ncc2cc(-c3nc(Cl)ns3)ccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],,val
US20040209865A1,Cc1cc(Br)cnc1N.O=C(Cl)CCl>>Cc1cc(Br)cnc1NC(=O)CCl,,ClCCl,,CCN(CC)CC,,val
US04794183,CCCCCCCCCCCCCCCCO[C@@H]1CCCO[C@H]1COCc1ccccc1>>CCCCCCCCCCCCCCCCO[C@@H]1CCCO[C@H]1CO,[Pd],CO,,[H][H],,val
US20120258948A1,FC(F)(Oc1ccc(Br)cc1)C1CCC2(CC1)OCCO2>>O=C1CCC(C(F)(F)Oc2ccc(Br)cc2)CC1,,CC(C)=O,,Cl,,val
US20110190256A1,CC(C)(Br)C(=O)Nc1cc(C(C)(C)C)on1.CCCCN>>CCCCNC(C)(C)C(=O)Nc1cc(C(C)(C)C)on1,,C1CCOC1,,[H-].[Na+],,val
US20070155727A1,COC(=O)c1ccc(CN2CCCNCC2)cc1.O=C(CCl)Nc1ccc(Oc2ccccc2)cc1>>COC(=O)c1ccc(CN2CCCN(CC(=O)Nc3ccc(Oc4ccccc4)cc3)CC2)cc1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20080021023A1,CNC(C)(CN1CCCC1)c1ccc(-c2ccccc2)cc1.O=C(O)Cn1c(=O)oc2ccc(Cl)cc21>>CN(C(=O)Cn1c(=O)oc2ccc(Cl)cc21)C(C)(CN1CCCC1)c1ccc(-c2ccccc2)cc1,,CN(C)C=O,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20140135304A1,C1COCCN1.O=C(CCl)Nc1ccc(OC2CCN(C3CCC3)CC2)cc1>>O=C(CN1CCOCC1)Nc1ccc(OC2CCN(C3CCC3)CC2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04788205,C=C1CC(=O)O1.Cc1nc(N)sc1C>>CC(=O)CC(=O)Nc1nc(C)c(C)s1,,Cc1ccccc1,,,,val
US05698575,S=c1c(Br)coc2ccccc12.c1ccc2[nH]ccc2c1>>S=c1cc(-c2cc3ccccc3[nH]2)oc2ccccc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060135578A1,CCOP(=O)(Cc1coc(C(C)C)n1)OCC.COCOc1nn(-c2ccccc2)cc1C=O>>COCOc1nn(-c2ccccc2)cc1/C=C\c1coc(C(C)C)n1,,C1CCOC1,,O,[H-].[Na+],val
US20130245002A1,Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCCNCC6)cc5c4)n3c2)cn1.OCCBr>>Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCCN(CCO)CC6)cc5c4)n3c2)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070208018A1,COC(=O)c1cc(F)c(C(F)(F)F)cc1[N+](=O)[O-].COc1ccc(-c2c[nH]cn2)cc1>>COC(=O)c1cc(-n2cnc(-c3ccc(OC)cc3)c2)c(C(F)(F)F)cc1[N+](=O)[O-],,C1CCOC1,,CCOC(C)=O,O,val
US20110218189A1,CC(C)(C)OC(=O)N1CCC[C@H](Cn2c(-c3c(Cl)cccc3Cl)cc3cnc(NCc4cccc(O)c4)nc32)C1>>Oc1cccc(CNc2ncc3cc(-c4c(Cl)cccc4Cl)n(CC4CCCNC4)c3n2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070037815A1,CN(C)C=O.FC1(F)Oc2ccc(Br)cc2O1>>O=Cc1ccc2c(c1)OC(F)(F)O2,,C1CCOC1,,[Li]CCCC,,val
US20090163469A1,CC(=O)Nc1nc(C)c(-c2ccnc(C3(C)CC3)c2)s1>>Cc1nc(N)sc1-c1ccnc(C2(C)CC2)c1,,CCO,,Cl,,val
US20120283273A1,C=C(OCC)c1cc(Cl)ncn1>>CC(=O)c1cc(Cl)ncn1,,CC(C)=O,,Cl,,val
US20140163000A1,CC(C)(C)OC(=O)Nc1cncc(F)c1C1CCN(C2COC2)CC1>>Nc1cncc(F)c1C1CCN(C2COC2)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070160526A1,CSCCC(NC(=O)OC(C)(C)C)C(=O)OCC[Si](C)(C)C>>CSCCC(N)C(=O)OCC[Si](C)(C)C,,ClCCl,O,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20020193367A1,CC(C)(C)OC(=O)Nc1cc(Cl)c(F)cc1[N+](=O)[O-].CNC>>CN(C)c1cc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])cc1F,,CS(C)=O,,,,val
US20160016948A1,Cc1nc2cnc(Nc3ccnc(Cl)n3)cc2n1C(C)C.N#CC1CCCNC1>>Cc1nc2cnc(Nc3ccnc(N4CCCC(C#N)C4)n3)cc2n1C(C)C,,CC(C)O,,CCN(CC)CC,,val
US20030203896A1,CCOC(=O)CCCn1ccc2c(NC[C@H](NC(=O)OCc3ccccc3)C(=O)OC(C)(C)C)nc(C)nc21.NC1=NCCCN1>>Cc1nc(NC[C@H](NC(=O)OCc2ccccc2)C(=O)O)c2ccn(CCCC(=O)NC3=NCCCN3)c2n1,,C1CCOC1,,C,C[O-].[Na+],val
US20120053205A1,CCOc1nc2cc(C(F)(F)F)ccc2c(C)c1C(=O)O.NCc1cccs1>>CCOc1nc2cc(C(F)(F)F)ccc2c(C)c1C(=O)NCc1cccs1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120238540A1,CC(=O)Cl.COc1cc(NC(=O)NCCCN)cc(Nc2nccc(-c3ccc(OC)c(C#N)c3)n2)c1>>COc1cc(NC(=O)NCCCNC(C)=O)cc(Nc2nccc(-c3ccc(OC)c(C#N)c3)n2)c1,,C1CCOC1,,CCN(CC)CC,,val
US03997536,CCCCCc1ccc(-c2ncc(C#N)c(Cl)n2)cc1>>CCCCCc1ccc(-c2ncc(C#N)cn2)cc1,[Zn],C1COCCO1,,,,val
US20030220345A1,CCNc1nc(SC)ncc1C=O.COc1cc(CC#N)cc(OC)c1>>CCn1c(=N)c(-c2cc(OC)cc(OC)c2)cc2cnc(SC)nc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120258948A1,CCOC(=O)[C@@](C)(CCn1cc(F)c(I)cc1=O)S(C)(=O)=O.OB(O)c1ccccc1>>CCOC(=O)[C@@](C)(CCn1cc(F)c(-c2ccccc2)cc1=O)S(C)(=O)=O,[Pd],C1COCCO1,,O,O=C([O-])[O-].[K+].[K+],val
US20120202968A1,C=CC[C@H](C)[C@H](C(=O)OC)N1C(=O)c2ccccc2C1=O>>C=CC[C@H](C)[C@@H](N)C(=O)O,,CC(=O)O,Cl,,,val
US20030004345A1,C=C(/C=C/P(=O)(OCC)OCC)CCO.Cc1ccc(S(=O)(=O)Cl)cc1>>C=C(/C=C/P(=O)(OCC)OCC)CCOS(=O)(=O)c1ccc(C)cc1,,ClCCl,,CCN(CC)CC,CN(C)c1ccccn1,val
US20050009785A1,BrC(Br)(Br)Br.Cc1oc(-c2ccccc2)nc1CCCCCO>>Cc1oc(-c2ccccc2)nc1CCCCCBr,,CCOCC,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070197393A1,C=CCc1cccc(Cl)c1C=O.NO>>C=CCc1cccc(Cl)c1C=NO,,CO,O,Cl,O=C([O-])O.[Na+],val
US20060287308A1,CC(C)(C)OC(=O)NC1CCNC1.CCOC(=O)c1cc(F)c(F)cc1F>>CCOC(=O)c1cc(F)c(C2CNCC2NC(=O)OC(C)(C)C)cc1F,,CC#N,CCOC(C)=O,CCN(CC)CC,,val
US04038271,CCOC(=O)C(N=C=O)c1ccccc1.NN1CC(=O)NC1=O>>CCOC(=O)C(NC(=O)NN1CC(=O)NC1=O)c1ccccc1,,C1COCCO1,,,,val
US20050245527A1,CI.O=c1cncc(CCN2CCC(COc3ccccc3F)CC2)[nH]1>>Cn1c(CCN2CCC(COc3ccccc3F)CC2)cncc1=O,,CCOC(C)=O,CN(C)C=O,O,[H-].[Na+],val
US20040063707A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(Cl)c(N)cnc21>>CC(C)[Si](C(C)C)(C(C)C)n1ccc2cc(N)cnc21,[Zn],CC(=O)O,CCOC(C)=O,,,val
US04198406,CCOC(=O)Cn1nnnc1S.CN>>CNC(=O)Cn1nnnc1S,,CCO,,,,val
US20150239920A1,CC(C)(C)OC(=O)CBr.CC(C)(C)[Si](C)(C)Oc1ccc2c(I)n[nH]c2c1>>CC(C)(C)OC(=O)Cn1nc(I)c2ccc(O[Si](C)(C)C(C)(C)C)cc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20030045557A1,Cn1nc(-c2ccc(C#N)cc2)sc1=NC1CC=CCC1.OO>>Cn1nc(-c2ccc(C(N)=O)cc2)sc1=NC1CC=CCC1,,CCO,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090069391A1,CCOC(=O)c1cc2ccc(C(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc2s1>>CCOC(=O)c1cc2ccc(C(C(=O)O)C(=O)O)cc2s1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090324569A1,Brc1nccs1.COc1ccc(Cc2ccc(N)cc2)c(F)c1-c1cccc(Cl)c1>>COc1ccc(Cc2ccc(Nc3nccs3)cc2)c(F)c1-c1cccc(Cl)c1,,CCO,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20100160322A1,CN(C)C=O.O=C1CCCOCC1.O=P(Cl)(Cl)Cl>>O=CC1=C(Cl)CCOCC1,,CCOC(C)=O,ClCCl,,,val
US20010021718A1,CCOC(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1>>CCOC(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)O)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110021522A1,COc1cccc2cc(C(=O)O)c(=O)oc12.COc1cncc(-c2cccc(N)c2)c1>>COc1cncc(-c2cccc(NC(=O)c3cc4cccc(OC)c4oc3=O)c2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20160016950A1,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F.Cl>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F.Cl,,CC(C)=O,,CCO,,val
US20090233919A1,CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C.COc1cc([N+](=O)[O-])ccc1N1CCC(O)CC1>>COc1cc([N+](=O)[O-])ccc1N1CCC(O[Si](C(C)C)(C(C)C)C(C)C)CC1,,CN(C)C=O,,CCN(CC)CC,,val
US20160235734A1,COC(=O)C(O)(c1ccccc1)c1cccc(NC(=O)NCCCNC(=O)OC(C)(C)C)c1>>CC(C)(C)OC(=O)NCCCNC(=O)Nc1cccc(C(O)(C(=O)O)c2ccccc2)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20050288329A1,CCOC(=O)COc1ccc(SC(C)(C)C(=O)NC2CCCCC2)cc1>>CC(C)(Sc1ccc(OCC(=O)O)cc1)C(=O)NC1CCCCC1,,C1CCOC1,CO,O,[Li+].[OH-],val
US20150291554A1,CC1CCC(O)CN1.O=C(Cl)OCc1ccccc1>>CC1CCC(O)CN1C(=O)OCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20130023526A1,COC(=O)c1cc(Br)nc(C)n1>>Cc1nc(Br)cc(CO)n1,,CO,,[BH4-].[Na+],,val
US20080015203A1,C1CCNCC1.C[C@@H](CO)Oc1cc(Oc2ccc(C(=O)O)cc2F)cc(C(=O)Nc2ccn(C)n2)c1>>C[C@@H](CO)Oc1cc(Oc2ccc(C(=O)N3CCCCC3)cc2F)cc(C(=O)Nc2ccn(C)n2)c1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05602252,CCc1ncc2c(=O)[nH]c3c(N(C)CCOCc4ccccc4)ncnc3n12>>CCc1ncc2c(=O)[nH]c3c(N(C)CCO)ncnc3n12,[Pd],,,CO,[Na+].[OH-],val
US20130096133A1,C1CNCCN1.Cc1ccc(CCl)cc1>>Cc1ccc(CN2CCNCC2)cc1,,C1CCOC1,,,,val
US05068393,CC1C(C)(C)c2ccccc2C1(C)C.O=C1CCC(=O)O1>>CC1C(C)(C)c2ccc(C(=O)CCC(=O)O)cc2C1(C)C,,ClCCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20110190235A1,CC(C)=O.CCCCN1CCOB(c2ccccc2Br)OCC1>>CC1(C)OB(O)c2ccccc21,,C1CCOC1,,Cl,[Li]CCCC,val
US04117039,CC(=O)c1ccccc1.CN(C)C=O.O=P(Cl)(Cl)Cl>>O=CC=C(Cl)c1ccccc1,,O,,CC(=O)[O-].[Na+],,val
US20160257653A1,O=C1c2ccccc2C(=O)N1CC/C=C/c1cccc([N+](=O)[O-])c1>>NCC/C=C/c1cccc([N+](=O)[O-])c1,,CCO,,NN,O,val
US20030055085A1,Fc1ccc(-c2noc(-c3cccc(Br)c3)n2)nc1.c1cncc(B2OCCCO2)c1>>Fc1ccc(-c2noc(-c3cccc(-c4cccnc4)c3)n2)nc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20080081029A1,C=C(C)C(=O)NCCCCCCCCCCC(=O)O.C=CC(=O)OCCN(C)C.CCl>>C=C(C)C(=O)NCCCCCCCCCCC(=O)O.C=CC(=O)OCCN(C)C.CCl,CC(C)(C#N)N=NC(C)(C)C#N,CO,,CC(C)=O,,val
US20130217709A1,COC(=O)C1=CCCN(C)C1>>COC(=O)C1=CCCN(C)C1,,ClCCl,O,Br,O=C([O-])[O-].[K+].[K+],val
US06410555B1,COc1ccc(C(=O)Nc2cnc3c(c2)CN(C)CC3(C)C)cc1C(F)(F)F.Cl>>COc1ccc(C(=O)Nc2cnc3c(c2)CNCC3(C)C)cc1C(F)(F)F.Cl,,CCOCC,,,,val
US05578620,CC(C)(C)OC(=O)N1CC(COc2cccc(Cl)c2)OC1=O>>O=C1NCC(COc2cccc(Cl)c2)O1,,C1CCOC1,,O=C(O)C(F)(F)F,,val
US04372953,CCC(=O)N(CC)CCCCl.Cn1nnnc1S>>CCC(=O)N(CC)CCCSc1nnnn1C,,CC(C)=O,,[I-].[K+],,val
US20160038504A1,COC(=O)c1ccnc(C(C)=O)c1.C[Mg]Br>>COC(=O)c1ccnc(C(C)(C)O)c1,,C1CCOC1,,CCOCC,,val
US20130005707A1,CC(C)(C)OC(=O)NCCNc1cc(Br)ccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)NCCNc1cc(Br)ccc1N,[Zn],C1CCOC1,CO,[Cl-].[NH4+],,val
US20050143394A1,C=O.OC1(C(CN2CCNCC2)c2cccc(C(F)(F)F)c2)CCC1>>CN1CCN(CC(c2cccc(C(F)(F)F)c2)C2(O)CCC2)CC1,,O=CO,,O,[Na+].[OH-],val
US20030125267A1,Clc1cnccn1.O=Cc1c[nH]cn1>>O=Cc1cn(-c2cnccn2)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20030045558A1,CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccc(Br)cc3)oc2C)cc1.OB(O)c1cccnc1>>CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccc(-c4cccnc4)cc3)oc2C)cc1,,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US04946843,CCOCCn1c(CN2CCN(CC#N)CC2)nc2cccnc21>>CCOCCn1c(CN2CCN(CCN)CC2)nc2cccnc21,[Ni],CO,,N,[H][H],val
US20120214803A1,N#Cc1ccc(N)c2ncccc12.O=[N+]([O-])c1cc(Cl)ccc1S(=O)(=O)Cl>>N#Cc1ccc(NS(=O)(=O)c2ccc(Cl)cc2[N+](=O)[O-])c2ncccc12,,C1CCOC1,,[H-].[Na+],,val
US20070003539A1,Cc1cc(F)c(I)cc1OC(=O)Oc1cc(I)c(F)cc1C>>Cc1cc(F)c(I)cc1O,,CCOC(C)=O,CO,[Na+].[OH-],,val
US20150291530A1,N#Cc1ccnc(C(F)(F)F)c1.O.[OH-]>>O=C(O)c1ccnc(C(F)(F)F)c1,,CCO,,Cl,,val
US20140121198A1,N[C@@H]1CC[C@H](n2cncn2)CC1.O=[N+]([O-])c1cnc2ccsc2c1Cl>>O=[N+]([O-])c1cnc2ccsc2c1N[C@@H]1CC[C@H](n2cncn2)CC1,,CC(C)O,,CCN(C(C)C)C(C)C,O=C(O)C(F)(F)F,val
US20140371199A1,N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)O)cc4)cn23)cc1.c1ccc(CN2CCNCC2)cc1>>N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)N5CCN(Cc6ccccc6)CC5)cc4)cn23)cc1,,CN(C)C=O,O,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20120270867A1,CCOC(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1.Nc1ccccc1F>>O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)Nc1ccccc1F,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20150038437A1,O=C(OCc1ccccc1)c1c(OCc2ccccc2)ncc(O)c1OCc1ccccc1.O=C1CCC(=O)N1Br>>O=C(OCc1ccccc1)c1c(OCc2ccccc2)nc(Br)c(O)c1OCc1ccccc1,,CN(C)C=O,,O,,val
US20060100246A1,CC(C)(C)OC(=O)N1CCCC(c2cc(-c3ccccc3O)nc(N)c2CN)C1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)N1CCCC(c2cc(-c3ccccc3O)nc3c2CNC(=O)N3)C1,,C1CCOC1,,,,val
US20130253004A1,CC(C)(C)O.Cn1ncc(Br)c1C(=O)O.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cn1ncc(Br)c1NC(=O)OC(C)(C)C,,Cc1ccccc1,,CCN(CC)CC,,val
US04831179,NC1CC1.O=S(=O)(Cl)Cc1cccc(C(F)(F)F)c1>>O=S(=O)(Cc1cccc(C(F)(F)F)c1)NC1CC1,,ClCCl,,CCN(CC)CC,,val
US04937268,BrCCCCCCBr.OCCOc1ccccc1>>BrCCCCCCOCCOc1ccccc1,,O,,[Na+].[OH-],,val
US20160137595A1,CC(C)C(O)C(C)C.O=[N+]([O-])c1cc(Br)ccc1F>>CC(C)C(Oc1ccc(Br)cc1[N+](=O)[O-])C(C)C,,C1CCOC1,,[Li]CCCC,,val
US20050142061A1,CN1CCCC1=O.CS(=O)(=O)Cl.O=C(NCCSC(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccccc1>>CS(=O)(=O)OCc1ccc(C(=O)NCCSC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,C1CCOC1,,,,val
US05849753,BrBr.Cc1cccc(N)n1>>Cc1nc(N)ccc1Br,,O,O=S(=O)(O)O,[Na+].[OH-],,val
US20030187289A1,COC(=O)c1ccc(OCCn2ccccc2=NC(=O)C(F)(F)F)cc1>>N=c1ccccn1CCOc1ccc(C(=O)O)cc1,,CCOCCO,,[Na+].[OH-],,val
US20110275673A1,CCCCCCCCC(N)=S.N#Cc1ccc(C(=O)CBr)cc1>>CCCCCCCCc1nc(-c2ccc(C#N)cc2)cs1,,CCO,,,,val
US20040249193A1,NC1CCCCC1.O=C(Cl)Cl>>O=C=NC1CCCCC1,,Clc1ccccc1,,,,val
US20030092720A1,CC(C)c1csc(COc2ccnc(NC(=O)OC(C)(C)C)c2)n1>>CC(C)c1csc(COc2ccnc(N)c2)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060052643A1,O=S(=O)(c1ccccc1)C(F)(F)CCCCc1ccccc1>>FC(F)CCCCc1ccccc1,,CO,,,,val
US20050171109A1,CCOC(=O)CCC(C)(C)c1ccc(Cl)c(OC)c1.O=S(=O)(c1ccccc1)N1OC1c1ccccc1>>CCOC(=O)C(O)CC(C)(C)c1ccc(Cl)c(OC)c1,,C1CCOC1,Cc1ccccc1,[Cl-].[NH4+],,val
US04849421,O=C1CC2CCSc3ccc(Cl)cc3C2=NN1c1ccc(Cl)cc1>>O=c1cc2c(nn1-c1ccc(Cl)cc1)-c1cc(Cl)ccc1SCC2,,CC(=O)O,,BrBr,,val
US20060223849A1,COC(=O)c1cc2ccccc2c(CCSC)n1>>CSCCc1nc(C(=O)O)cc2ccccc12,,CO,,C1CCOC1,[Li+].[OH-],val
US03937716,CC(C)C1OCCN1CC1CO1.CO>>COCC(O)CN1CCOC1C(C)C,,CO,,C[O-].[Na+],,val
US20070287701A1,COc1ccc2ncc(C#N)c(CCN3CCC(C)(CN)C3)c2c1.O=Cc1ccc2c(n1)NC(=O)CS2>>COc1ccc2ncc(C#N)c(CCN3CCC(C)(CNCc4ccc5c(n4)NC(=O)CS5)C3)c2c1,,CO,ClCCl,Cl,,val
US20120196884A1,Cc1cc(N)ccc1N1C(=O)c2ccc(Cl)cc2C1=O.O=C=Nc1ccccc1>>Cc1cc(NC(=O)Nc2ccccc2)ccc1N1C(=O)c2ccc(Cl)cc2C1=O,,CCOC(C)=O,,,,val
US04992433,C#CCOC(=O)c1ccc(O)cc1.ClCCC1CCN(c2ccc(Cl)nn2)CC1>>C#CCOC(=O)c1ccc(OCCC2CCN(c3ccc(Cl)nn3)CC2)cc1,,O,,CC(=O)N(C)C,O=C([O-])[O-].[K+].[K+],val
US20120149718A1,Cc1ccccc1C[C@H](C(=O)O)c1ccc(S(C)(=O)=O)cc1.Nc1nc2ccccc2o1>>Cc1ccccc1C[C@H](C(=O)Nc1nc2ccccc2o1)c1ccc(S(C)(=O)=O)cc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20050267149A1,COC(=O)c1ccccc1COc1ccc(CCC(=O)N2CCc3ccccc3C2)cc1>>O=C(O)c1ccccc1COc1ccc(CCC(=O)N2CCc3ccccc3C2)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20090099195A1,CC(C)N1Cc2c(Cl)nc(Cl)nc2C1=O.Cc1ccccc1CC(C)(C)N>>Cc1ccccc1CC(C)(C)Nc1nc(Cl)nc2c1CN(C(C)C)C2=O,,ClCCCl,,CCN(C(C)C)C(C)C,,val
US04981981,CC(C)=CC/C=C(/C)[C@H]1CCC2(C)O[C@H]2C1.O=[O+][O-]>>CC(=O)C1CCC2(C)OC2C1,,ClCCl,,CSC,,val
US05618821,COc1ccc(CCCO)cn1.Cc1cc(-c2noc(C(F)(F)F)n2)cc(C)c1O>>COc1ccc(CCCOc2c(C)cc(-c3noc(C(F)(F)F)n3)cc2C)cn1,,ClCCl,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070293567A1,COC(=O)C(CC(C)C)c1cc(Oc2cccc(C(C)C)c2)cc(-c2ccc(C(F)(F)F)cc2)c1>>CC(C)CC(C(=O)O)c1cc(Oc2cccc(C(C)C)c2)cc(-c2ccc(C(F)(F)F)cc2)c1,,CO,,C1CCOC1,[Li+].[OH-],val
US20100150827A1,CSc1nc(C)cc(NC2CCOC2)n1.ClI>>CSc1nc(C)c(I)c(NC2CCOC2)n1,,CO,,,,val
US20040053908A1,C1CCNC1.Cc1c(NC(=O)NC2CC2)ccc(Oc2ccnc3cc(OC[C@H]4CO4)c(C#N)cc23)c1C>>Cc1c(NC(=O)NC2CC2)ccc(Oc2ccnc3cc(OC[C@H](O)CN4CCCC4)c(C#N)cc23)c1C,,C1CCOC1,,,,val
US20070060596A1,CCOC(=O)c1cc(C)n(C(C)c2cc(Cl)ccc2OCc2ccc(F)cc2Cl)n1>>Cc1cc(C(=O)O)nn1C(C)c1cc(Cl)ccc1OCc1ccc(F)cc1Cl,,CCO,O,CC(=O)O,[Na+].[OH-],val
US20100076027A1,N#Cc1ccc(NC(=O)C(c2c3c(nn2-c2ccc(Cl)cc2)CCCC3)C2CCCCC2)c(F)c1.[N-]=[N+]=[N-]>>O=C(Nc1ccc(-c2nnn[nH]2)cc1F)C(c1c2c(nn1-c1ccc(Cl)cc1)CCCC2)C1CCCCC1,,CN(C)C=O,,[Cl-].[NH4+],,val
US20160095844A1,CC(=O)c1ccc2c(c1)N(C)C(=O)C2(C)C.COC(=O)C1CC1>>CN1C(=O)C(C)(C)c2ccc(C(=O)CC(=O)C3CC3)cc21,,C1CCOC1,,[H-].[Na+],,val
US20050171087A1,N[C@@H]1CCCN2c3cc(Cl)ccc3Oc3ccccc3[C@H]12.O=C1OC(=O)C(F)(F)C1(F)F>>O=C(O)C(F)(F)C(F)(F)C(=O)N[C@@H]1CCCN2c3cc(Cl)ccc3Oc3ccccc3[C@H]12,,C1COCCO1,,,,val
US20120010237A1,CCOc1c(-c2ccc(Oc3ccc(OC(F)(F)F)cc3)cc2)c(C)nc2cc(OC)c(Cl)cc12>>COc1cc2[nH]c(C)c(-c3ccc(Oc4ccc(OC(F)(F)F)cc4)cc3)c(=O)c2cc1Cl,,CC(=O)O,,Br,,val
US20140275071A1,CCCSc1nc2c(c(=O)[nH]c(=O)n2C)n1Cc1ccc(Cl)cc1.OC1(CCBr)CC1>>CCCSc1nc2c(c(=O)n(CCC3(O)CC3)c(=O)n2C)n1Cc1ccc(Cl)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110218193A1,CCCBr.COc1ccc(Cn2c(=O)c3c(c4cc(OC)ccc42)NCCC3)cc1>>CCCN1CCCc2c1c1cc(OC)ccc1n(Cc1ccc(OC)cc1)c2=O,,CN(C)C=O,,O,[H-].[Na+],val
US20030146412A1,Clc1nc(-c2ccc(Oc3ccccc3)cc2)nc(-c2ccc(Oc3ccccc3)cc2)n1.Oc1cccc(O)c1>>Oc1ccc(-c2nc(-c3ccc(Oc4ccccc4)cc3)nc(-c3ccc(Oc4ccccc4)cc3)n2)c(O)c1,,Clc1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20020107273A1,CCc1nc2cc(O[Si](C)(C)C(C)(C)C)ccc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1>>CCc1nc2cc(O)ccc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US06100293,COc1ccccc1CCBr>>Oc1ccccc1CCBr,,ClCCl,,BrB(Br)Br,,val
US20160159804A1,N#CBr.c1ccc(Oc2ccc(Oc3ncnc4ccn(CC5CNC5)c34)cc2)cc1>>N#CN1CC(Cn2ccc3ncnc(Oc4ccc(Oc5ccccc5)cc4)c32)C1,,ClCCl,O,O=C([O-])O.[Na+],,val
US20130131132A1,Cn1cnc(S(=O)(=O)NCc2ccc3c(c2)C(Cc2ccccc2)C(NC(=O)[C@H]2C[C@H]2C(=O)O)CC3)c1>>Cn1cnc(S(=O)(=O)NCc2ccc3c(c2)C(Cc2ccccc2)C(N2C(=O)C4CC4C2=O)CC3)c1,,C1CCOC1,O,CC(=O)Cl,,val
US20110130453A1,CCOC(=O)Cc1cccc(Oc2ccc(NC(C)=O)cc2CN(C(=O)OC)[C@@H](C)Cc2ccccc2)c1>>COC(=O)N(Cc1cc(NC(C)=O)ccc1Oc1cccc(CC(=O)O)c1)[C@@H](C)Cc1ccccc1,,C1CCOC1,,Cl,[Li+].[OH-],val
US04507498,BrCCCBr.CCCc1c(OCCCCCC(=O)OC)ccc(C(C)=O)c1O>>CCCc1c(OCCCCCC(=O)OC)ccc(C(C)=O)c1OCCCBr,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160200725A1,CC(C)(C)OC(=O)N1CC(=O)C1.CN[C@@H](C)C(=O)O>>C[C@@H](C(=O)O)N(C)C1CN(C(=O)OC(C)(C)C)C1,,CO,,[BH3-]C#N.[Na+],,val
US20080305956A1,CO.Cc1c(C(=O)O)ccc(Cl)c1S>>COC(=O)c1ccc(Cl)c(S)c1C,,O,O=S(=O)(O)O,,,val
US20110034460A1,C1COCCN1.C=O.O=Cc1ccc[nH]1>>O=Cc1cc(CN2CCOCC2)c[nH]1,,CC(=O)O,,,,val
US20120283297A1,CC(C)Oc1ncc(C(=O)O)cc1Cl.CCOC(=O)CCCn1ncc2cc(C(=N)NO)c(C)cc21>>CCOC(=O)CCCn1ncc2cc(-c3noc(-c4cnc(OC(C)C)c(Cl)c4)n3)c(C)cc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090105253A1,CCNC(=O)c1ccc(-n2nnc(C(=O)NC3CC3)c2COS(C)(=O)=O)cc1.OCC(F)F>>CCNC(=O)c1ccc(-n2nnc(C(=O)NC3CC3)c2COCC(F)F)cc1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20120196994A1,CO.NC1CCCCC1.O=CC1CCc2ccccc2N1>>CC1CCCCC1/N=C/c1cccc2c1NCCC2,,CO,,CCCCCC,,val
US20120258973A1,COC(=O)C1CC(O)=NN1C.O=P(Cl)(Cl)Cl>>COC(=O)C1CC(Cl)=NN1C,,ClC(Cl)Cl,,,,val
US20120193577A1,CCC[C@@H]1CC[C@@H](/C=C/CCC2CCC(O)CC2)CC1>>CCC[C@@H]1CC[C@@H](/C=C/CCC2CCC(=O)CC2)CC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US06458781B1,Fc1ccc(C(CCCBr)c2ccc(F)cc2)cc1.O=C1NC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1CCCC(c1ccc(F)cc1)c1ccc(F)cc1,,CN(C)C=O,,O,[K],val
US20060116400A1,CC(C)(C)[Si](C)(C)OCC1(CO[Si](C)(C)C(C)(C)C)CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cc2)=NO1>>O=C1O[C@@H](Cn2ccnn2)CN1c1ccc(-c2ccc(C3=NOC(CO)(CO)C3)cc2)c(F)c1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US05455274,CC(C)NC(C)C.O=C(O)c1ccc(O)cc1>>CC(C)N(C(=O)c1ccc(O)cc1)C(C)C,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20110251222A1,C[C@@H](O)[C@@H](C)OCc1ccccc1.FC(F)(F)c1cnc(Cl)nc1Cl>>C[C@@H](Oc1nc(Cl)ncc1C(F)(F)F)[C@@H](C)OCc1ccccc1,,CC#N,CCOCC,[H-].[Na+],,val
US20080287475A1,CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N(C)S(C)(=O)=O)c2Cl)n[nH]1.Cl>>C[C@H](N)c1ncc(F)cn1.Cl,,C1COCCO1,ClCCl,,,val
US20040186160A1,COc1ccc2c(c1)NC(=O)C2.O=Cc1[nH]c2c(c1CCCO)CCCCC2>>COc1ccc2c(c1)NC(=O)/C2=C\c1[nH]c2c(c1CCCO)CCCCC2,,CCO,,C1CCNCC1,,val
US20040242648A1,CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl.COC(=O)C1=C(C)NC(COCCNC(=O)COc2ccc(C3=NNC(=O)CC3)cc2Cl)=C(C(=O)OC)C1c1ccccc1Cl>>CCOC(=O)C1=C(COCCNC(=O)COc2ccc(C3=NNC(=O)CC3)cc2Cl)NC(C)=C(C(=O)OC)C1c1ccccc1Cl,,CCOC(C)=O,,,,val
US05866592,CCCCC(NC(=O)OC(C)(C)C)C(C)(C)C(=O)O.COC(=O)CC1CCNCC1>>CCCCC(NC(=O)OC(C)(C)C)C(C)(C)C(=O)C1CCCCN1CC(=O)OC,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100240638A1,CN(C)C=C1CN(C(=O)OC(C)(C)C)CC1=O.CN1CCN(C(=N)N)CC1>>CN1CCN(c2ncc3c(n2)CN(C(=O)OC(C)(C)C)C3)CC1,,CCO,,C[O-].[Na+],,val
US20160214974A1,CC(C)(C)OC(=O)N1[C@H]2C=C[C@@H]1CC(C#N)(c1cncc(I)c1)C2>>N#CC1(c2cncc(I)c2)C[C@@H]2C=C[C@H](C1)N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080021028A1,Brc1ncccn1.C[C@@H]1CNCCN1>>C[C@@H]1CN(c2ncccn2)CCN1,,Cc1ccccc1C,,,,val
US20090137595A1,Cc1cc(C(=O)Cl)n(C)n1.Nc1cccc(Oc2ccc3nc(NC(=O)CC4CC4)cn3n2)c1>>Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)CC5CC5)cn4n3)c2)n(C)n1,,CC(=O)N(C)C,,,,val
US20120040985A1,COc1cc(C(C)(C)C(=O)CNC(=S)Nc2ccc(F)cc2)ccc1Cl>>COc1cc(C(C)(C)c2cnc(S)n2-c2ccc(F)cc2)ccc1Cl,,CC(=O)O,,CCOCC,,val
US06265575B1,O=C(/C=C/c1ccc(-c2cc3ccccc3s2)cc1)N1CCCC1>>c1ccc2sc(-c3ccc(CCCN4CCCC4)cc3)cc2c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20070072847A1,COC1CCN(C2CCN(Cc3ccccc3)CC2)CC1>>COC1CCN(C2CCNCC2)CC1,[Pd],CO,O,[H][H],,val
US05134111,COCCl.Cc1cccc2c(C=O)ccc(O)c12>>COCOc1ccc(C=O)c2cccc(C)c12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04665174,C=CCC1C(=O)C=CC1(C)O.COc1ccc(CO)cc1OC>>C=CCC1=C(C)C(OCc2ccc(OC)c(OC)c2)CC1=O,,C1CCOC1,,[H-].[Na+],,val
US06002008,CCCI.CCOC(C)=O.CN(C)C=O.N#Cc1cnc2cc(O)c(O)cc2c1Nc1cccc(Br)c1>>CCCOc1cc2ncc(C#N)c(Nc3cccc(Br)c3)c2cc1OCCC,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US05308754,COC(=O)CN(CC(=O)OC)Cc1cc(C(=O)c2cccc([N+](=O)[O-])c2)cc(CN(CC(=O)OC)CC(=O)OC)c1O>>COC(=O)CN(CC(=O)OC)Cc1cc(C(=O)c2cccc(N)c2)cc(CN(CC(=O)OC)CC(=O)OC)c1O,[Pd],CO,,,,val
US05254595,CC(=O)Nc1ccc(OCC2CO2)cc1.NC1CCc2ccccc2C1>>CC(=O)Nc1ccc(OCC(O)CNC2CCc3ccccc3C2)cc1,,CS(C)=O,,O,,val
US04535183,CCOC(=O)CCCCBr.COc1ccc(O)c(C=O)c1OC>>CCOC(=O)CCCCOc1ccc(OC)c(OC)c1C=O,,CCO,,[I-].[K+],O=C([O-])O.[Na+],val
US04662933,C1CO1.CC(C)(C)NS(=O)(=O)c1ccccc1>>CC(C)(C)NS(=O)(=O)c1ccccc1CCO,,C1CCOC1,,O,[Li]CCCC,val
US20030125370A1,CC(=O)N1CCN(Cc2c(C)[nH]c(C=O)c2C)CC1.O=C1Cc2cc(S(=O)(=O)Cc3c(Cl)cccc3Cl)ccc2N1>>CC(=O)N1CCN(Cc2c(C)[nH]c(/C=C3\C(=O)Nc4ccc(S(=O)(=O)Cc5c(Cl)cccc5Cl)cc43)c2C)CC1,C1CCNCC1,CCO,,,,val
US04012413,CC(=O)O.CCC=O.NCCN.NCCc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2>>CCCN(CCC)CCc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2,,C1CCOC1,CC(=O)O,[BH3-]C#N.[Na+],,val
US04550105,COC(=O)C(=NO)C(C)=O.O=S(=O)(Cl)Cl>>COC(=O)C(=NO)C(=O)CCl,,ClCCl,,,,val
US20160264552A1,CC(C)(C)OC(=O)N1CCC(N)CC1.O=S(=O)(c1ccccc1)n1cc(-c2nc(Cl)ncc2Cl)c2ccccc21>>CC(C)(C)OC(=O)N1CCC(Nc2ncc(Cl)c(-c3cn(S(=O)(=O)c4ccccc4)c4ccccc34)n2)CC1,,CCOC(C)=O,CN1CCCC1=O,CCN(C(C)C)C(C)C,,val
US20040097572A1,C=CCC(O)[C@@H](C)N(c1cc(Cl)ccc1Cl)S(=O)(=O)c1ccc(Cl)cc1>>CCCC(O)[C@@H](C)N(c1cc(Cl)ccc1Cl)S(=O)(=O)c1ccc(Cl)cc1,[Pt],CCO,,,,val
US05026856,COc1cccc2c1CNC2.Nc1c(F)c(F)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1>>COc1cccc2c1CN(c1c(F)c(N)c3c(=O)c(C(=O)O)cn(C4CC4)c3c1F)C2,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US05438052,CC(C)(ON)C(=O)NNC(=O)c1ccc(O)c(O)c1.Cc1nc2nc(C(=O)NO)cc(SCC3=C(C(=O)O)N4C(=O)[C@@H](NC(=O)C(=O)c5csc(N)n5)[C@H]4SC3)n2n1>>Cc1nc2nc(C(=O)NO)cc(SCC3=C(C(=O)O)N4C(=O)[C@@H](NC(=O)/C(=N\OC(C)(C)C(=O)NNC(=O)c5ccc(O)c(O)c5)c5csc(N)n5)[C@H]4SC3)n2n1,,CC(=O)N(C)C,,Cl,,val
US05128351,Br.CCCCCCCCCCCCCCOc1ccc(NC(=O)Nc2cccc(CO)c2)cc1>>CCCCCCCCCCCCCCOc1ccc(NC(=O)Nc2cccc(CBr)c2)cc1,,CC(=O)O,ClC(Cl)Cl,,,val
US20140323513A1,CCOC(=O)C(C)=C1CCN(C)CC1>>CCOC(=O)C(C)C1=CCN(C)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20140364431A1,O=C([O-])c1cn(-c2ccc(F)cc2)c2ccccc2c1=O>>O=C(O)c1cn(-c2ccc(F)cc2)c2ccccc2c1=O,,CCO,,[Na+].[OH-],,val
US20130109855A1,CCN(CC)C(=O)Cl.Oc1cccc(I)c1>>CCN(CC)C(=O)Oc1cccc(I)c1,,C1CCOC1,,[H-].[Na+],,val
US20110294837A1,COc1ccc2c(Cl)ccnc2c1.O=[N+]([O-])c1ccc(O)c(F)c1>>COc1ccc2c(Oc3ccc([N+](=O)[O-])cc3F)ccnc2c1,CN(C)c1ccncc1,C1COCCO1,,c1ccncc1,,val
US20090197863A1,CCOC(=O)c1cccc(N)c1O.O=C(Cl)C1CCN(C(=O)OCc2ccccc2)CC1>>COC(=O)c1cccc(NC(=O)C2CCN(C(=O)OCc3ccccc3)CC2)c1O,,ClCCl,,CCN(CC)CC,,val
US20040138301A1,Cc1[nH]c2c(Br)cccc2c1C=O.N#CCC(O)C#N>>Cc1[nH]c2c(Br)cccc2c1C=C(C#N)C#N,,CCO,,C1CCNCC1,,val
US20110172099A1,CC(C)(C)C(=O)Cn1cncn1.CC(CBr)Cc1ccc(F)cc1F>>CC(Cc1ccc(F)cc1F)CC(C(=O)C(C)(C)C)n1cncn1,,CC#N,,[K+].[OH-],,val
US20080221201A1,CC(C)N.O=S(=O)(Cl)c1cc(F)c(Br)cc1F>>CC(C)NS(=O)(=O)c1cc(F)c(Br)cc1F,,ClCCl,,,,val
US05290934,CCOC(=O)c1cn(CC)c2cc(F)c(F)c(C)c2c1=O>>CCn1cc(C(=O)O)c(=O)c2c(C)c(F)c(F)cc21,,CC(=O)O,,Cl,,val
US20090318668A1,COC(=O)C(=Cc1ccc(OC)c(OCCCl)c1)N=[N+]=[N-]>>COC(=O)c1cc2cc(OCCCl)c(OC)cc2[nH]1,,Cc1ccccc1,,,,val
US20030187026A1,CC(C)(C)C(=O)Nc1ccncc1C=O>>Nc1ccncc1C=O,,Cl,,,,val
US20090162319A1,CN(C)C(OC(C)(C)C)N(C)C.Cc1cc(Br)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(C)c1[N+](=O)[O-]>>Cc1cc(Br)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(/C=C/N(C)C)c1[N+](=O)[O-],,CN(C)C=O,,,,val
US20070021442A1,COc1cc(F)c(Cl)c(Oc2cc(Cl)cc(C#N)c2)c1>>N#Cc1cc(Cl)cc(Oc2cc(O)cc(F)c2Cl)c1,,ClCCl,,BrB(Br)Br,,val
US05817698,CCOC(=O)Cl.N[C@@H]1CCC[C@@H]1COc1ccc(Cc2ccccc2)cc1>>CCOC(=O)N[C@@H]1CCC[C@@H]1COc1ccc(Cc2ccccc2)cc1,,CCOCC,,CCN(CC)CC,,val
US20130210704A1,ClCCCN1CCCCC1.NC(N)=S>>SCCCN1CCCCC1,,CCO,O,Cl,[Na+].[OH-],val
US20080261920A1,COC(=O)C(NC(=O)OC(C)(C)C)c1cccc(O)c1.OC1CCOCC1>>COC(=O)C(NC(=O)OC(C)(C)C)c1cccc(OC2CCOCC2)c1,,C1CCOC1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080262244A1,CCCN(CCC)CCc1cccc([N+](=O)[O-])c1C.CCOC(=O)C(=O)OCC>>CCCN(CCC)CCc1cccc([N+](=O)[O-])c1CC(=O)C(=O)OCC,,C1CCOC1,C1CCOC1,[H-].[Na+],,val
US20080319005A1,CC(C)N1CCN(Cc2ccc(N)cc2C(F)(F)F)CC1.Cc1cc(-n2cnc3cccnc32)ccc1CC(=O)O>>Cc1cc(-n2cnc3cccnc32)ccc1CC(=O)Nc1ccc(CN2CCN(C(C)C)CC2)c(C(F)(F)F)c1,,CO,ClCCl,,,val
US20130123506A1,ClC(Cl)=CCBr.O=C1OCC=C1NCc1ccc(Cl)nc1>>O=C1C=C(N(CC=C(Cl)Cl)Cc2ccc(Cl)nc2)CO1,,C1CCOC1,,CO,[H-].[Na+],val
US20060235031A1,CC(=O)OC(C)=O.NCC1CCC1c1nc(-c2ccc3ccc(-c4ccccc4)nc3c2)c2c(N)nccn12>>CC(=O)NC[C@@H]1C[C@H](c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(N)nccn23)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US06187777B1,C1COCCN1.Cc1cc2[nH]c(C)nc(Cl)c-2n1>>Cc1cc2[nH]c(C)nc(N3CCOCC3)c-2n1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20120134934A1,O=C(NC(C(=O)O)c1ccccc1)OCc1ccccc1.O[C@H]1CN2CCC1CC2>>O=C(NC(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1)OCc1ccccc1,,C1CCOC1,,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20050148627A1,BrBr.COc1cccc(C=O)c1O>>COc1cc(Br)cc(C=O)c1O,,CC(=O)O,O,,,val
US20110230462A1,Nc1cccc(Br)c1.O=C1OC(=O)C2CC12>>O=C1C2CC2C(=O)N1c1cccc(Br)c1,,ClCCl,,O=C(n1ccnc1)n1ccnc1,,val
US20080234250A1,CC(C)(C)OC(=O)N(CCNC(=O)OCc1ccccc1)c1c(F)cccc1C(=O)O>>CC(C)(C)OC(=O)N1CCNC(=O)c2cccc(F)c21,[Pd],CO,,CC(=O)O,,val
US20090318421A1,O=C(NCc1ccc(F)cc1F)c1cn2c(c(OCc3ccccc3)c1=O)C(=O)N1C(C2)OCC2CC(c3ccccc3)CCC21>>O=C(NCc1ccc(F)cc1F)c1cn2c(c(O)c1=O)C(=O)N1C(C2)OCC2CC(c3ccccc3)CCC21,[Pd],CO,,,,val
US20040122244A1,CC(=O)c1ccc(N)cc1.COC1=C(OC)C(=O)C(Cc2ccc(OCc3cccnc3)c(C(=O)O)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(OCc3cccnc3)c(C(=O)Nc3ccc(C(C)=O)cc3)c2)=C(C)C1=O,,ClCCl,,CCN(CC)CC,CN1CC[NH+](C)C1Cl.[Cl-],val
US20050107364A1,COC(=O)C1(CCC(C)C)C(OC)=CC(=O)c2ccccc21>>COC(=O)C1(CCC(C)C)C(=O)CC(=O)c2ccccc21,,CC#N,,C[Si](C)(C)I,,val
US20040034049A1,COc1c(C)c(C)c(OC)c(C(O)C2CCN(Cc3ccccc3)CC2)c1C>>Cc1c(C)c2c(c(C)c1O)CC1(CCN(Cc3ccccc3)CC1)O2,,CC(=O)O,,Br,[Na+].[OH-],val
US20130217668A1,CC(C)(O)C1CCNCC1.O=Cc1ccc([N+](=O)[O-])c(F)c1>>CC(C)(O)C1CCN(Cc2ccc([N+](=O)[O-])c(F)c2)CC1,,ClCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20080312226A1,CC(C)(C)OC(=O)N1CCNCC1.FC(F)(F)c1cccc(-c2csc(Br)n2)c1>>CC(C)(C)OC(=O)N1CCN(c2nc(-c3cccc(C(F)(F)F)c3)cs2)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20060276465A1,COC(=O)c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)c(C2=CC(C)(C)CC(C)(C)C2)c1>>COC(=O)c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)c(C2CC(C)(C)CC(C)(C)C2)c1,[Pd],C1CCOC1,,CO,,val
US04250183,CC(C)(C)CC(C)(C)N(CCCC(=O)O)C(=O)c1cccc(C(F)(F)F)c1.CCOC(=O)CCN>>CC(C)(C)CC(C)(C)N(CCCC(=O)NCCC(=O)O)C(=O)c1cccc(C(F)(F)F)c1,,CCO,,[K+].[OH-],,val
US06054457,COc1cc(C(=O)N(C)c2ccc(C)cc2OCCCCCC(=O)N2CCN(C)CC2)ccc1O.O=[N+]([O-])c1ccccc1CBr>>COc1cc(C(=O)N(C)c2ccc(C)cc2OCCCCCC(=O)N2CCN(C)CC2)ccc1OCc1ccccc1[N+](=O)[O-],,CN(C)C=O,,[H-].[Na+],,val
US20130225574A1,CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@@H]2[C@H]1OC(=O)N2c1cc(-c2cnc(N)nc2C(F)(F)F)nc(N2CCOCC2)n1>>Nc1ncc(-c2cc(N3C(=O)O[C@H]4[C@H](O)CC[C@H]43)nc(N3CCOCC3)n2)c(C(F)(F)F)n1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110251196A1,CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1.O=CC1CC1>>CCCC(C)COc1ccc([C@H](CNCC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1,,CC#N,,O=C([O-])O.[Na+],,val
US20160016908A1,CC(=O)N1c2ccc(C(N)=O)cc2[C@H](Nc2cccc(CO[Si](C)(C)C(C)(C)C)n2)[C@@H](C)[C@@H]1C1CC1>>CC(=O)N1c2ccc(C(N)=O)cc2[C@H](Nc2cccc(CO)n2)[C@@H](C)[C@@H]1C1CC1,,C1CCOC1,CO,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US09266853B2,CC#CCOc1ccc(C[C@H](N)C(=O)OC)cc1.CCCCCCCSCCCCCC/C=C/[C@H](C(=O)N1C(=O)SC(c2ccccc2)(c2ccccc2)[C@@H]1C(C)C)[C@@](O)(CCOC)C(=O)OC(C)(C)C>>CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCSCCCCCCC)[C@@](O)(CCOC)C(=O)OC(C)(C)C)C(=O)OC)cc1,,ClCCl,,,,val
US20150218172A1,CC(C)(COC1CCCCO1)n1cc(I)c2cnc(Cl)nc21.CON(C)C(=O)c1ccc(C#N)c(F)c1>>CC(C)(COC1CCCCO1)n1cc(C(=O)c2ccc(C#N)c(F)c2)c2cnc(Cl)nc21,,CCOCC,,[Li]CCCC,,val
US20160009667A1,N#Cc1cc(C2CC2)c(F)cc1F.OCC1CCC(F)(F)CC1>>N#Cc1cc(C2CC2)c(OCC2CCC(F)(F)CC2)cc1F,,CN(C)C=O,O,[H-].[Na+],,val
US20100286211A1,Clc1ncc(Br)cn1.c1ccc2[nH]cnc2c1>>Brc1cnc(-n2cnc3ccccc32)nc1,,CN1CCCC1=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130102776A1,COc1ccc2c(c1/C=C\CCN1CCN(C(=O)OC(C)(C)C)CC1)OCC2=O.O=Cc1n[nH]c2ccccc12>>COc1ccc2c(c1/C=C\CCN1CCN(C(=O)OC(C)(C)C)CC1)O/C(=C\c1n[nH]c3ccccc13)C2=O,C1CCNCC1,CO,,,,val
US20070281955A1,CC(C)(C)OC(=O)N1CCC[C@@H](Nc2nccc(-c3c(-c4cccc(C#N)c4)nc4sccn34)n2)C1.Cl>>Cl.N#Cc1cccc(-c2nc3sccn3c2-c2ccnc(N[C@@H]3CCCNC3)n2)c1,,CCOC(C)=O,,,,val
US20060235031A1,O=P(Br)(Br)Br.O=c1cc(-c2ccccc2)[nH]c2c(F)c(Cl)ccc12>>Fc1c(Cl)ccc2c(Br)cc(-c3ccccc3)nc12,,CC#N,,,,val
US20100217012A1,Cc1ccc(S(=O)(=O)OC[C@H]2CO2)cc1.O=[N+]([O-])c1ccc(O)c(OCc2ccccc2)c1>>O=[N+]([O-])c1ccc(OC[C@H]2CO2)c(OCc2ccccc2)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US05321135,COc1ccc(CCCCc2cc(OC)c(OC)c(OC)c2)cc1OC>>COc1cc2c(cc1OC)-c1c(cc(OC)c(OC)c1OC)CCCC2,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,,val
US20040023973A1,N#Cc1ccccc1F.O=c1[nH]cc(-c2ccccc2)cc1-c1ccccn1>>N#Cc1ccccc1-n1cc(-c2ccccc2)cc(-c2ccccn2)c1=O,,O,,CN(C)C=O,[H-].[Na+],val
US20110288299A1,CC12CCCc3cc(N)cc(c31)CCC2.CCOC(=O)c1cnc(Cl)nc1>>CCOC(=O)c1cnc(Nc2cc3c4c(c2)CCCC4(C)CCC3)nc1,,O,,O=C([O-])[O-].[K+].[K+],,val
US04360673,O=C(OCC(Cl)(Cl)Cl)C1C2CCN1CC(=NN(c1ccccc1)c1ccccc1)C2>>c1ccc(N(N=C2CC3CCN(C2)C3)c2ccccc2)cc1,[Zn],CC(=O)O,,,,val
US20150353532A1,Cc1cc(N2C[C@](c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C=N2)ccc1C(=O)O.O=C(Cl)C(=O)Cl>>Cc1cc(N2C[C@](c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C=N2)ccc1C(=O)Cl,,ClCCl,,CN(C)C=O,,val
US20150087663A1,CCC(N)=NOC(=O)c1c(Cl)ncnc1Cl.N>>CCC(N)=NOC(=O)c1c(N)ncnc1Cl,,C1CCOC1,,CO,ClCCl,val
US20110144136A1,CC(C)I.CCCCOc1nc(N)c2nc(OC)n(CC3CCCNC3)c2n1>>CCCCOc1nc(N)c2[nH]c(=O)n(CC3CCCN(C(C)C)C3)c2n1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US05082841,CCCC(=O)c1cnc2c(N3C(=O)c4ccccc4C3=O)cccc2c1Nc1ccccc1C>>CCCC(=O)c1cnc2c(N)cccc2c1Nc1ccccc1C,,CCO,,NN,O,val
US20030092749A1,Nc1ccccc1.O=C(O)c1ccc(Cl)c([N+](=O)[O-])c1>>O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1,[Cu],CC(C)CCO,,CN1CCOCC1,,val
US20090099156A1,CC(C)(C)OC(=O)N1CCN(C2CCC2)C[C@@H]1C(=O)N1CCNCC1.O=C=Nc1ccc(C(F)(F)F)cc1>>CC(C)(C)OC(=O)N1CCN(C2CCC2)C[C@@H]1C(=O)N1CCN(C(=O)Nc2ccc(C(F)(F)F)cc2)CC1,,ClCCl,,CCN(CC)CC,,val
US20110112075A1,C1CCCNCC1.COc1c(N2CCOCC2=O)cc(F)cc1S(=O)(=O)N[C@@H](CNC(=O)c1ccc(Cl)s1)C(=O)O>>COc1c(N2CCOCC2=O)cc(F)cc1S(=O)(=O)N[C@@H](CNC(=O)c1ccc(Cl)s1)C(=O)N1CCCCCC1,,CN(C)C=O,,,,val
US05635104,O=C(Cl)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1.O=C1CCCCCN1>>O=C1CCCCCN1C(=O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20130005707A1,NCCO.Nc1ccnc(Cl)c1>>NCCOc1cc(N)ccn1,,C1COCCO1,,O,[H-].[Na+],val
US20070254896A1,CCN.COC(=O)Cc1ccc(OC)cc1>>CCNC(=O)Cc1ccc(OC)cc1,,CS(C)=O,,[H-].[Na+],,val
US20020193410A1,COC(=O)C=CCOc1ccc(C#N)cc1I>>COC(=O)CC1COc2ccc(C#N)cc21,,C1CCOC1,CCOCC,,,val
US04963552,Cl.N#Cc1ncn2c1N(C(=O)CN1CCN(Cc3ccccc3)CC1)CC=C2c1cccc(C(F)(F)F)c1>>Cl.N#Cc1ncn2c1N(C(=O)CN1CCN(Cc3ccccc3)CC1)CC=C2c1cccc(C(F)(F)F)c1,,CCO,,CCOCC,,val
US20110021482A1,C#CCO.COC(=O)C1CN1C(C)=O>>C#CCOC[C@@H](NC(C)=O)C(=O)OC,,ClCCl,,CCOCC,FB(F)F,val
US20140057914A1,O=C(O)Cc1cccc(Br)c1>>OCCc1cccc(Br)c1,,C1CCOC1,,B,,val
US20140135330A1,CC[C@@H]([C@@H](O)c1ccc(OC)cc1)[N+](=O)[O-]>>CC[C@H](N)[C@@H](O)c1ccc(OC)cc1,[Pd],CCO,,,,val
US20110136792A1,CCOC(=O)CN(Cc1cccc(COc2ccc(-c3cc(F)c(F)cc3F)cc2)c1)S(=O)(=O)CC>>CCS(=O)(=O)N(CC(=O)O)Cc1cccc(COc2ccc(-c3cc(F)c(F)cc3F)cc2)c1,,C1CCOC1,,[Li+].[OH-],,val
US20150336942A1,CC(C)n1cc(-c2cc(Br)cnc2N)nn1.O=C(c1cc(B(O)O)ccc1F)N1CCOCC1>>CC(C)n1cc(-c2cc(-c3ccc(F)c(C(=O)N4CCOCC4)c3)cnc2N)nn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04411911,CCCCCCCC(=O)C=[N+]=[N-].Cc1cc(C)c(S(=O)(=O)O)c(C)c1>>CCCCCCCC(=O)COS(=O)(=O)c1c(C)cc(C)cc1C,,CCOCC,,O,O,val
US20050282823A1,C1=C(c2cccnc2)CC2CNCC1C2.Cl.Cl>>Cl.Cl.c1cncc(C2CC3CNCC(C3)C2)c1,[Pd],CO,,[H][H],,val
US20130217702A1,CC[N+](=O)[O-].Cc1nc(-c2[nH]c3ccccc3c2C=O)no1>>Cc1nc(-c2[nH]c3ccccc3c2C#N)no1,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20070043020A1,CCI.Nc1n[nH]cc1C(=O)c1ccccc1>>CCn1cc(C(=O)c2ccccc2)c(N)n1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20140288045A1,O=C1NC(=O)c2ccccc21.OCCOc1ccnc(Oc2cc(Cl)c(Cl)cc2I)c1>>O=C1c2ccccc2C(=O)N1CCOc1ccnc(Oc2cc(Cl)c(Cl)cc2I)c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04284634,CC(=O)CC(=O)OCCOCc1ccccc1.O=Cc1cccc([N+](=O)[O-])c1>>CC(=O)C(=Cc1cccc([N+](=O)[O-])c1)C(=O)OCCOCc1ccccc1,,c1ccccc1,,C1CCNCC1,CC(=O)O,val
US20100324086A1,CC(C)(C)OC(=O)Nc1cccc(C(=O)Nc2ccc3ccccc3n2)c1>>Nc1cccc(C(=O)Nc2ccc3ccccc3n2)c1,,O=C(O)C(F)(F)F,,,,val
US20070161627A1,COc1ccc2nccc(CCN3CCC(N(C)C(=O)OC(C)(C)C)C3)c2n1>>CNC1CCN(CCc2ccnc3ccc(OC)nc23)C1,,CO,,Cl,,val
US20090270511A1,CI.COC(=O)[C@H](CS)NC(=O)OC(C)(C)C>>COC(=O)[C@H](CSC)NC(=O)OC(C)(C)C,,CN(C)C=O,O,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20090197862A1,Cc1cccc2cc(O)ncc12.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cccc2cc(OS(=O)(=O)C(F)(F)F)ncc12,,ClCCl,,CCN(CC)CC,,val
US04064239,O=Cc1cccc([N+](=O)[O-])c1.O=[N+]([O-])c1cccc(C(Cl)Cl)c1>>O=[N+]([O-])c1cccc(C=C(Cl)Cl)c1,,ClC(Cl)(Cl)Cl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20140045936A1,COC(=O)C1(c2ccccc2)CC1/C=C/c1ccccc1.O=[O+][O-]>>COC(=O)C1(c2ccccc2)CC1C=O,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120035140A1,CCOP(=O)(OCC)C(=O)NCC(CN)N=[N+]=[N-].O=S(=O)(Cl)c1ccc(Oc2ccccc2)cc1>>CCOP(=O)(OCC)C(=O)NCC(CNS(=O)(=O)c1ccc(Oc2ccccc2)cc1)N=[N+]=[N-],,CC#N,,CCN(CC)CC,,val
US20160207926A1,CC(C)(C)OC(=O)N[C@H]1CCNC1.O=C(Cl)C1CC1>>CC(C)(C)OC(=O)N[C@H]1CCN(C(=O)C2CC2)C1,,ClCCl,,CCN(CC)CC,,val
US20120214803A1,COc1ccc2cccnc2c1[N+](=O)[O-]>>COc1ccc2cccnc2c1N,Cl,,,Cl[Sn]Cl,,val
US04716238,CC1(C)CC(=O)c2cc(OCc3ccccc3)c(OCc3ccccc3)cc2O1>>CC1(C)C=Cc2cc(OCc3ccccc3)c(OCc3ccccc3)cc2O1,Cl[Pd]Cl,C1CCOC1,O,[BH4-].[Na+],,val
US20090182001A1,Cn1cncc1C(=O)O.Nc1ccc(Cl)cc1Br>>Cn1cncc1C(=O)Nc1ccc(Cl)cc1Br,,ClCCl,,O=S(Cl)Cl,,val
US20040029874A1,CC(C)(C)c1ccc(C(=O)Cl)cc1.Nc1ccc(C(=O)O)cc1C(=O)O>>CC(C)(C)c1ccc(C(=O)Nc2ccc(C(=O)O)cc2C(=O)O)cc1,,CC(C)=O,,O,,val
US20140329794A1,NCC(O)CN1CCc2ccccc2C1.Nc1ccc(F)c(C(=O)O)c1>>Nc1ccc(F)c(C(=O)NCC(O)CN2CCc3ccccc3C2)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20150051133A1,C/C(=C\C1CCC(C)CC1)CCC=O>>CC1CCC(CC(C)CCC=O)CC1,[Pd],C1CCCCC1,,,,val
US20130150341A1,CN1C(=O)N(C2CCN(Cc3ccccc3)CC2)Cc2ccccc21>>CN1C(=O)N(C2CCNCC2)Cc2ccccc21,[Pd],CO,,[H][H],,val
US05134152,C[C@H](C1CO1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F>>C[C@H](O)[C@@H](C)[C@](O)(Cn1cncn1)c1ccc(F)cc1F,,CCOCC,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US04743290,CC(C)(C)NS(=O)(=O)c1sccc1C#N>>N#Cc1ccsc1S(N)(=O)=O,,O=C(O)C(F)(F)F,,,,val
US06326386B1,CCCN(C(=O)c1cc(O)cc(Cl)c1)c1cc(F)cc(F)c1.Cc1ccc(S(=O)(=O)OCCN(C(=O)OC(C)(C)C)c2ccncc2)cc1>>CCCN(C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1)c1cc(F)cc(F)c1,,CN(C)C=O,,[H-].[Na+],,val
US04282031,NNCc1ccccc1.S=C=Nc1ccccc1>>NN(Cc1ccccc1)C(=S)Nc1ccccc1,,CC(C)O,,,,val
US20100022761A1,Cc1ccc2ccc(O)c(Br)c2n1.O=S(=O)(Cl)c1ccccc1>>Cc1ccc2ccc(OS(=O)(=O)c3ccccc3)c(Br)c2n1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140303153A1,COC(=O)c1c(CCl)cn(C)c(=O)c1Cl.NCCc1cn2ccccc2n1>>Cn1cc2c(c(Cl)c1=O)C(=O)N(CCc1cn3ccccc3n1)C2,,CC#N,,,,val
US04612321,COC(=O)CCCc1nc(-c2ccc(OC)cc2)c(-c2cccnc2)s1>>COc1ccc(-c2nc(CCCCO)sc2-c2cccnc2)cc1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20140315949A1,C=C(C)B1OC(C)(C)C(C)(C)O1.CC(C)(C)OC(=O)c1ccc(Br)cc1Cl>>C=C(C)c1ccc(C(=O)OC(C)(C)C)c(Cl)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20110070317A1,Cc1nc(C(=O)O)cs1.Nc1c[nH]c2ncc(Br)c(F)c12>>Cc1nc(C(=O)Nc2c[nH]c3ncc(Br)c(F)c23)cs1,,ClCCl,,CCN(CC)CC,O=C1OCCN1P(=O)(Cl)N1CCOC1=O,val
US05059608,C1CCNCC1.CC1(c2ccccc2)c2ccccc2CCN1C(=O)CCl>>CC1(c2ccccc2)c2ccccc2CCN1C(=O)CN1CCCCC1.Cl,,ClCCl,,O,,val
US05910495,COc1ccc(N(C(=O)CNc2ccccc2Nc2ccccc2)C(C)C)cc1.O=C(Cl)C(=NNc1ccccc1)C(=O)Cl>>COc1ccc(N(C(=O)Cn2c(=O)c(=NNc3ccccc3)c(=O)n(-c3ccccc3)c3ccccc32)C(C)C)cc1,,C1CCOC1,,,,val
US20090143402A1,CC[C@H](NC(=O)c1c(C)n(-c2ccccc2)c(=O)c2c([N+](=O)[O-])cccc12)c1ccccc1>>CC[C@H](NC(=O)c1c(C)n(-c2ccccc2)c(=O)c2c(N)cccc12)c1ccccc1,[Zn],,,C1CCOC1,,val
US20100075948A1,CC(C)(C)CC1NC(C(=O)OC(C)(C)C)C(c2cccc(F)c2)C1(C#N)c1ccc(Cl)cc1F.O=C(O)C(F)(F)F>>CC(C)(C)CC1NC(C(=O)O)C(c2cccc(F)c2)C1(C#N)c1ccc(Cl)cc1F.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20100316955A1,C=Cc1ccc(S(=O)(=O)[O-])cc1.c1ccc([S+](c2ccccc2)c2ccccc2)cc1>>C=Cc1ccc(S(=O)(=O)[O-])cc1.c1ccc([S+](c2ccccc2)c2ccccc2)cc1,,ClCCl,,O,[Cl-].[Na+],val
US20140350019A1,CC(C)OC(=O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F.OCCO>>O=C(COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F)OCCO,,OCCO,,O,O=S(=O)(O)O,val
US20110201663A1,CCOC(=O)Cc1ccc(N)c(F)c1.CCOc1c2c(c(OCC)c3ccccc13)C(=O)OC2=O>>CCOC(=O)Cc1ccc(N2C(=O)c3c(c(OCC)c4ccccc4c3OCC)C2=O)c(F)c1,CN(C)c1ccncc1,CC(=O)O,ClCCl,,,val
US04245088,CC(=O)CC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)Cc3ccccc3)[C@H]2SC1.Cn1nnnc1S>>Cn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(NC(=O)Cc3ccccc3)[C@H]2SC1,,O,,O=C([O-])O.[Na+],,val
US20110166121A1,CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(C(=O)O)nc2s1.NCC(O)CO>>CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(C(=O)NCC(O)CO)nc2s1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090203667A1,C=CCc1c(O)cccc1[N+](=O)[O-].O=C(OO)c1cccc(Cl)c1>>O=[N+]([O-])c1cccc2c1CC(CO)O2,,ClC(Cl)Cl,,,,val
US20070254873A1,Cn1cnc(S(=O)(=O)Cl)c1.NC(=O)c1cc(-c2ccccc2)cc2c(C3CCNCC3)c[nH]c12>>Cn1cnc(S(=O)(=O)N2CCC(c3c[nH]c4c(C(N)=O)cc(-c5ccccc5)cc34)CC2)c1,,ClCCl,,CCN(CC)CC,,val
US20040033896A1,Cc1cnc(-c2ccc(C(F)(F)F)cc2)nc1CBr.FC(F)(F)c1cc[nH]n1>>Cc1cnc(-c2ccc(C(F)(F)F)cc2)nc1Cn1ccc(C(F)(F)F)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20130196970A1,COC(=O)c1ccc2c(-c3cccc(C(F)(F)F)c3)c[nH]c2c1>>O=C(O)c1ccc2c(-c3cccc(C(F)(F)F)c3)c[nH]c2c1,,C1CCOC1,O,[Li]O,,val
US20050026914A1,CCN(C(C)C)C(C)C.COc1cc([N+](=O)[O-])ccc1N.Nc1ccccc1.O=C(Cl)CCl>>CN1CCC(c2ccc(N)cc2)CC1,,ClCCl,,,,val
US03999991,COc1ccc(OC)cc1.O=C(Cl)c1cccc([N+](=O)[O-])c1>>COc1ccc(OC)c(C(=O)c2cccc([N+](=O)[O-])c2)c1,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20050127319A1,CO.COC(=O)OC.Cn1ccnc1>>COC(=O)[O-].Cn1cc[n+](C)c1,,CO,,O=C=O,,val
US20010047014A1,O[C@H]1CN(CCOc2ccc(OCc3ccccc3)cc2)CC[C@@]1(O)Cc1ccccc1>>Oc1ccc(OCCN2CC[C@@](O)(Cc3ccccc3)[C@@H](O)C2)cc1,[Pd],CCO,,,,val
US20120245171A1,Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12.O=C(O)CN1CCCCC1>>O=C(CN1CCCCC1)Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040067900A1,N[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O.Nc1ncnc(Cl)c1[N+](=O)[O-]>>Nc1ncnc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1[N+](=O)[O-],,CN(C)C=O,O,CCN(CC)CC,,val
US20030022887A1,COc1cc2cc(CO)ccc2c(OC)c1OC>>COc1cc2cc(C=O)ccc2c(OC)c1OC,,ClCCl,,O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1,,val
US20100160411A1,[N-]=[N+]=NCC1Oc2c(cc(F)cc2-c2c(Cl)cccc2Cl)S1>>NCC1Oc2c(cc(F)cc2-c2c(Cl)cccc2Cl)S1,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20070265281A1,C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)O.NS(=O)(=O)c1cccc2cc[nH]c12>>C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)NS(=O)(=O)c1cccc2cc[nH]c12,,C1CCOC1,CCOC(C)=O,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20100137275A1,CN(CCN)CCNc1cc(N2CCCC2)nc(N2CCCC2)n1.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>CN(CCNC(=O)Nc1ccc(Cl)c(C(F)(F)F)c1)CCNc1cc(N2CCCC2)nc(N2CCCC2)n1,,ClCCl,,CCOCC,,val
US20100240678A1,CC(=O)c1cc(OS(=O)(=O)C(F)(F)F)cc(OS(=O)(=O)C(F)(F)F)c1>>CC(=O)c1cc(O)cc(OS(=O)(=O)C(F)(F)F)c1,,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05403854,CCOc1c(OCC)c(=O)c1=O.Nc1cccc2cnccc12>>CCOc1c(Nc2cccc3cnccc23)c(=O)c1=O,,CCO,,,,val
US07518000B2,O=C(O)c1ccc2[nH]ccc2c1.[Li]C>>CC(=O)c1ccc2[nH]ccc2c1,,C1CCOC1,,,,val
US20150175575A1,Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-n2cnc(C3(O)CCN(C(=O)OCc4ccccc4)CC3)c2)c1>>Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-n2cnc(C3(O)CCNCC3)c2)c1,[Pd],CO,,[H][H],,val
US20020165229A1,C[Si](C)(C)C#Cc1cc2c(Cl)c(C#N)cnc2cn1.Nc1cccc(Br)c1>>C[Si](C)(C)C#Cc1cc2c(Nc3cccc(Br)c3)c(C#N)cnc2cn1,,CCO,,,,val
US20050176955A1,COC(=O)c1nc(N(C)S(C)(=O)=O)c2cccnc2c1OS(=O)(=O)c1ccc(C)cc1>>COC(=O)c1nc(N(C)S(C)(=O)=O)c2cccnc2c1O,,CN(C)C=O,CO,CC(=O)O,C[O-].[Na+],val
US20150361031A1,C[C@H](N)c1ccccc1.O=C(O)c1cc(Cl)ccc1O>>CC(NC(=O)c1cc(Cl)ccc1O)c1ccccc1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070259877A1,COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1N.O=S(=O)(Cl)c1ccc(Br)cc1Cl>>COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1Cl,,ClCCl,,CN1CCOCC1,,val
US04696949,Brc1ccccc1.O=C(c1ccccc1)C(CCOC1CCCCO1)c1ccccc1>>OC(c1ccccc1)(c1ccccc1)C(CCOC1CCCCO1)c1ccccc1,,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US20110071150A1,COc1nccc(B(O)O)c1Cl.Cn1nc(C(F)(F)F)cc1-c1ccc2[nH]c(OS(=O)(=O)C(F)(F)F)cc2c1>>COc1nccc(-c2cc3cc(-c4cc(C(F)(F)F)nn4C)ccc3[nH]2)c1Cl,,C1COCCO1,,,,val
US04777179,CCCC(c1cc(C)c(C2OCCO2)s1)N1C(=O)c2ccccc2C1=O>>Cc1cc(CCCCN)sc1C1OCCO1,,C1CCOC1,,NN,O,val
US20100022775A1,CC(C)(C)OC(=O)N1CCC(Nc2cccc3cnccc23)C1.O=C(O)[C@](O)(C(=O)c1ccccc1)[C@](O)(C(=O)O)C(=O)c1ccccc1>>CC(C)(C)OC(=O)N1CC[C@@H](Nc2cccc3cnccc23)C1.O=C(O)[C@](O)(C(=O)c1ccccc1)[C@](O)(C(=O)O)C(=O)c1ccccc1,,CC(C)O,,,,val
US20070244131A1,CC(=O)Cl.Nc1nc2ccc(Br)cc2s1>>CC(=O)Nc1nc2ccc(Br)cc2s1,,C1CCOC1,,CCN(CC)CC,O,val
US05292873,Cc1cccc2c1C(=O)C=C(SC(C)C(=O)O)C2=O.O=C1CCC(=O)N1Br>>CC(SC1=CC(=O)c2c(CBr)cccc2C1=O)C(=O)O,,CC(=O)OC(C)=O,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US04940703,CI.COc1ccc2[nH]cc(C#N)c2c1>>COc1ccc2c(c1)c(C#N)cn2C,,C1CCOC1,,[H][H],[H-].[Na+],val
US20060100229A1,Cc1c2c(nn1Cc1ccccc1)c(N)nc1ccccc12>>Cc1[nH]nc2c(N)nc3ccccc3c12,,Br,CC(=O)O,,,val
US07439360B2,CC(C)N1CCNCC1.C[Si](C)(C)CCOCn1c(N2CCN(c3ncccc3C(F)(F)F)CC2)nc(C(=O)O)c1-c1ccc(C(F)(F)F)cc1>>CC(C)N1CCN(C(=O)c2nc(N3CCN(c4ncccc4C(F)(F)F)CC3)[nH]c2-c2ccc(C(F)(F)F)cc2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20110207711A1,COc1cc(-c2cnn(C)c2)cn2nccc12.O=C1CCC(=O)N1I>>COc1cc(-c2cnn(C)c2)cn2ncc(I)c12,,CC#N,ClCCl,,,val
US20160168100A1,COc1cc(C)c(Br)cc1OCc1ccccc1.COc1cc2c(cc1OCc1ccccc1)CCN=C2>>COc1cc2c(cc1OCc1ccccc1)CCNC2c1cc(OCc2ccccc2)c(OC)cc1C,,C1CCOC1,,[Li]C(C)(C)C,,val
US04282365,O=C(Cl)c1ccc2c(c1)C(=O)c1ccccc1CO2.O=C(O)CCO>>O=C(O)CCOC(=O)c1ccc2c(c1)C(=O)c1ccccc1CO2,,C1CCOC1,,[Na],,val
US04021441,CC=CCN.Fc1cccc(F)c1C1=NCc2nnc(CCl)n2-c2ccc(Cl)cc21>>C=CCCNCc1nnc2n1-c1ccc(Cl)cc1C(c1c(F)cccc1F)=NC2,,C1CCOC1,,[I-].[K+],,val
US20140221393A1,CCC#CCCO.Cc1ccc(S(=O)(=O)Cl)cc1>>CCC#CCCOS(=O)(=O)c1ccc(C)cc1,CN(C)c1ccncc1,,,CCN(CC)CC,,val
US20040052822A1,COC(OC)C1=C(C#N)C(c2ccccc2Cl)c2c[nH]nc2N1>>N#CC1=C(C=O)Nc2n[nH]cc2C1c1ccccc1Cl,,O=C(O)C(F)(F)F,,,,val
US20060205718A1,CCOc1cc(C(=O)OC)cc([N+](=O)[O-])c1O.O=C(Cl)C(=O)Cl>>CCOc1cc(C(=O)OC)cc([N+](=O)[O-])c1Cl,,CN(C)C=O,,,,val
US20040152732A1,NC(Cc1c[nH]c2ccccc12)C(=O)O.O=C(Cl)CCc1ccccc1>>O=C(CCc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20140205537A1,CC(C)Oc1ccc([N+](=O)[O-])c(CC(=O)O)c1>>CC(C)Oc1ccc2c(c1)CC(=O)N2,[Fe],CC(=O)O,,,,val
US20130018049A1,COC(=O)c1c(C(=O)O)n(C)c2ccccc12.OCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COC(=O)c1c(NC(=O)OCc2ccccc2)n(C)c2ccccc12,,CN(C)C=O,,CCN(CC)CC,,val
US05545652,CCOC(=O)CNc1ccc(OCC(F)(F)C(F)F)cc1.O=C(Cl)CCl>>CCOC(=O)CN(C(=O)CCl)c1ccc(OCC(F)(F)C(F)F)cc1,,ClCCl,,CCN(CC)CC,,val
US20010031874A1,COc1ccc(C(=O)Nc2ccccc2)cc1N.O=Cc1ccccc1>>COc1ccc(C(=O)Nc2ccccc2)cc1NCc1ccccc1,,ClCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US20160083365A1,C[C@H](N)c1cc2cc(Cl)ccc2[nH]c1=O.FC(F)(F)Cn1cncc1-c1ccnc(Cl)n1>>C[C@H](Nc1nccc(-c2cncn2CC(F)(F)F)n1)c1cc2cc(Cl)ccc2[nH]c1=O,,CCO,,CCN(C(C)C)C(C)C,Cl,val
US20110160201A1,CI.OCc1ccc(CCBr)cc1>>COCc1ccc(CCBr)cc1,,C1CCOC1,,O,[H-].[Na+],val
US04336322,C=C(C)c1ccccc1.CCCCCCCCCCCCCCCCOc1ccc(NC(C)=O)c(O)c1>>CCCCCCCCCCCCCCCCOc1cc(O)c(NC(C)=O)cc1C(C)(C)c1ccccc1,,Cc1ccccc1,,CO,,val
US20120172599A1,CC1=C(C#N)C(=C(C#N)C#N)OC1(C)C(F)(F)F.CCCCN(CCCC)c1ccc(C=Cc2ccc(C=O)s2)c(OC)c1>>CCCCN(CCCC)c1ccc(C=Cc2ccc(C=CC3=C(C#N)C(=C(C#N)C#N)OC3(C)C(F)(F)F)s2)c(OC)c1,,C1CCOC1,CCO,,,val
US20060111351A1,CC(=O)OC(C)=O.O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(N2CCNCC2)cc1>>CC(=O)N1CCN(c2ccc(S(=O)(=O)Nc3ccc(Cl)cc3C(=O)c3ccncc3)cc2)CC1,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US04640915,COC(C)(C)[C@@H]1C(=O)N[C@@H]1CC(=O)CC(=O)OCc1ccc([N+](=O)[O-])cc1.Cc1ccc(S(=O)(=O)N=[N+]=[N-])cc1>>COC(C)(C)[C@@H]1C(=O)N[C@@H]1CC(=O)C(=[N+]=[N-])C(=O)OCc1ccc([N+](=O)[O-])cc1,,CC#N,,CCN(CC)CC,,val
US20090044345A1,CCN(CC)CC.CNCc1ncc(C)c(OC)c1C.Cl.Oc1cc(CCl)nc(-c2ccccn2)n1>>COc1c(C)cnc(CN(C)Cc2cc(O)cc(-c3cc(Cl)ccn3)n2)c1C,,C1CCOC1,,,,val
US20070155744A1,FC(F)(F)I.O=C(NCc1ccc(F)cc1)c1cc(I)nc(OCc2ccccc2)c1OCc1ccccc1>>O=C(NCc1ccc(F)cc1)c1cc(C(F)(F)F)nc(O)c1O,[Cu],c1ccncc1,,,,val
US20070129347A1,N.N#CCOC(=O)CCCCc1c[nH]c2ccccc12>>NC(=O)CCCCc1c[nH]c2ccccc12,,C1CCOC1,,,,val
US20080207902A1,CCc1cc2c(C(=O)C(C)Br)cc(F)cn2n1.COC(=O)CC(=O)OC>>CCc1cc2c(C(=O)C(C)C(C(=O)OC)C(=O)OC)cc(F)cn2n1,,CN(C)C=O,,[H-].[Na+],,val
US20120088767A1,CCCC[Sn](CCCC)(CCCC)c1ncco1.Cc1c(Cn2c(C)nc3c(Br)cc(N4CCOCC4)cc32)cccc1C(F)(F)F>>Cc1c(Cn2c(C)nc3c(-c4ncco4)cc(N4CCOCC4)cc32)cccc1C(F)(F)F,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,,,val
US20070105904A1,Brc1ccc(Br)nc1.Sc1ccccc1>>Brc1ccc(Sc2ccccc2)nc1,,O,,CN(C)C=O,[H-].[Na+],val
US20090118327A1,NCC(c1ccc([N+](=O)[O-])cc1)c1cccc(Cl)c1.S=C(Cl)Cl>>O=[N+]([O-])c1ccc(C(CN=C=S)c2cccc(Cl)c2)cc1,,ClCCl,,O=C([O-])O.[Na+],,val
US04080323,CCO.O=C1CC(=C[N+](=O)[O-])Nc2ccccc2N1c1ccccc1>>Cc1ncc2n1-c1ccccc1N(c1ccccc1)C(=O)C2,[Ni],C1CCOC1,,,,val
US20060263411A1,Clc1ccc(Cl)nn1.OCc1ccccn1>>Clc1ccc(OCc2ccccn2)nn1,,C1CCOC1,,[H-].[Na+],,val
US20130274260A1,Cc1ccc(B(O)O)cc1.O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(CCl)cc1>>Cc1ccc(Cc2ccc(C(=O)NCCc3c[nH]c4ccc(Cl)cc34)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,[I-].[Na+],,val
US20040137273A1,CN(C)C=O.Cc1cc(Br)c(C)cc1Br.N.N#C[Cu]>>Cc1cc(C#N)c(C)cc1C#N,,O,,,,val
US20070082912A1,CCOC(=O)c1cccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)c1>>Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(C(=O)O)c1,,CCO,,[Na+].[OH-],,val
US20070093483A1,CCCCNC(=S)NN.O=C(O)Cc1ccccc1Cl>>CCCCn1c(Cc2ccccc2Cl)n[nH]c1=S,,ClCCl,,,,val
US20100272680A1,CC(C)(C)OC(=O)N1CC[C@@H](N2CCCC2=O)[C@H](O[Si](C)(C)C(C)(C)C)C1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C1CCCN1,,ClCCl,,,,val
US20080004309A1,CCOC(=O)CNCc1ccc(OC)cc1OC.CCOC(=O)c1sc(-c2cncc(Br)c2)nc1CBr>>CCOC(=O)CN(Cc1ccc(OC)cc1OC)Cc1nc(-c2cncc(Br)c2)sc1C(=O)OCC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080167310A1,C=C(C=Cc1ccc(O)cc1C#N)OCC>>C=C(CCc1ccc(O)cc1C#N)OCC,[Pd],CCOC(C)=O,,[H][H],,val
US20060052445A1,C=C[Sn](CCCC)(CCCC)CCCC.O=S(=O)(c1ccc(Cl)nc1)c1ccccc1F>>C=Cc1ccc(S(=O)(=O)c2ccccc2F)cn1,,C1CCOC1,CCOC(C)=O,,,val
US20030186968A1,C1CNCCN1.O=S(=O)(c1ccccc1)c1ccc(Cl)cn1>>O=S(=O)(c1ccccc1)c1ccc(N2CCNCC2)cn1,,c1ccncc1,,,,val
US20120196851A1,COC(=O)[C@@H]1CC[C@@H](Cn2c(=O)[nH]c3ccccc3c2=O)CC1>>O=C(O)[C@@H]1CC[C@@H](Cn2c(=O)[nH]c3ccccc3c2=O)CC1,,C1CCOC1,O,[Li+].[OH-],,val
US20150274738A1,CC(C)(C)OC(=O)N1CCNCC1.Nc1ncnc2c1c(I)nn2C1CCC(=O)CC1>>CC(C)(C)OC(=O)N1CCN(C2CCC(n3nc(I)c4c(N)ncnc43)CC2)CC1,,ClCCCl,ClCCl,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20090054463A1,OCCC(c1ccc(F)cc1)c1ccc(F)cc1>>O=CCC(c1ccc(F)cc1)c1ccc(F)cc1,,CCOCC,CS(C)=O,CCN(CC)CC,c1ccncc1,val
US20080234237A1,CN1CCC(N2CCc3ccccc32)CC1.O=C1CCC(=O)N1Br>>CN1CCC(N2CCc3cc(Br)ccc32)CC1,,CN(C)C=O,O,,,val
US20070082908A1,CCOC(=O)c1cn2nc(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)c(Cc3ccccc3Cl)c2c(=O)[nH]1.ClCc1cccc2ccccc12>>CCOC(=O)c1cn2nc(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)c(Cc3ccccc3Cl)c2c(=O)n1Cc1cccc2ccccc12,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20080015353A1,COC=CC(=O)C(C)(OC)OC.N=C(N)c1ccccc1>>COC(C)(OC)c1ccnc(-c2ccccc2)n1,,CCOC(C)=O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US05665718,CCCN(CCC)Cc1nnc(-c2ncn3c2[C@@H]2CCCN2C(=O)c2c(Cl)cccc2-3)o1.Cl>>CCCN(CCC)Cc1nnc(-c2ncn3c2[C@@H]2CCCN2C(=O)c2c(Cl)cccc2-3)o1.Cl,,CCO,,CCOCC,,val
US20110015240A1,O=C(O)c1cccc(CBr)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(O)c1cccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1.[Br-],,CC#N,,,,val
US20040116694A1,O=[N+]([O-])c1cccc2nc(CN3CCOCC3)ccc12>>Nc1cccc2nc(CN3CCOCC3)ccc12,[Pd],CO,,O=C([O-])[O-].[K+].[K+],,val
US20150045359A1,CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(N)cc2)C1.Clc1cccnc1Cl>>CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Nc3ncccc3Cl)cc2)C1,,C1COCCO1,,CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21,O=C([O-])[O-].[Cs+].[Cs+],val
US20070155729A1,NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl.O=C(Cl)C(=O)Cl>>NS(=O)(=O)c1cc(C(=O)Cl)c(NCc2ccco2)cc1Cl,,ClCCl,,,,val
US20140155391A1,CI.COC(=O)c1cc(C=O)ccc1O>>COC(=O)c1cc(C=O)ccc1OC,,CC#N,CCOC(C)=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20100190764A1,COC(=O)C1=CCCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1.O>>COC(=O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1,,CC#N,,,,val
US20160075722A1,CC1(C)COB(c2cccc(C#N)c2)OC1.O=Cc1cccc(Br)c1>>N#Cc1cccc(-c2cccc(C=O)c2)c1,,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20060287287A1,Cc1cc(C#N)cc(C)c1N>>Cc1cc(CN)cc(C)c1N,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060211709A1,CNC(=O)c1nc(-c2cccc(C(=O)NCC3CCCN3)c2)cnc1N.O=Cc1ccccc1>>CNC(=O)c1nc(-c2cccc(C(=O)NCC3CCCN3Cc3ccccc3)c2)cnc1N,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20060135505A1,N#Cc1ccc(C(F)(F)F)c(N2CCCCC2)c1>>NCc1ccc(C(F)(F)F)c(N2CCCCC2)c1,,C1CCOC1,,O,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US20160137652A1,COC(=O)CC1(C)CCNCC1.Fc1ccc2nccc(Cl)c2c1>>COC(=O)CC1(C)CCN(c2ccnc3ccc(F)cc23)CC1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,Cl,val
US20130029990A1,COCC(=O)Nc1cc(O)ccn1.N#Cc1c(F)ccc([N+](=O)[O-])c1Cl>>COCC(=O)Nc1cc(Oc2ccc([N+](=O)[O-])c(Cl)c2C#N)ccn1,,CC#N,,C1CCC2=NCCCN2CC1,O,val
US20020156076A1,C1CCOC1.CN(C)S(=O)(=O)n1c(Sc2ccccc2)cnc1[Si](C)(C)C(C)(C)C>>CN(C)S(=O)(=O)n1c(C=O)cnc1[Si](C)(C)C(C)(C)C,,CCOCC,,,,val
US04607030,CN(C)C=NS(=O)(=O)c1cc(C(C)(C)C)cc(CNC(=O)CCl)c1O.Cl>>CC(C)(C)c1cc(CN)c(O)c(S(N)(=O)=O)c1.Cl,,CCO,Cl,,,val
US20090149456A1,O=C(Cc1cccs1)Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc4c(c3)CC(NC(=O)C(F)(F)F)CC4)n2)c1>>NC1CCc2ccc(Nc3nccc(-c4c(-c5cccc(NC(=O)Cc6cccs6)c5)nn5ccccc45)n3)cc2C1,,CO,,[Li+].[OH-],,val
US05545636,CCOC(=O)C1CCn2c(cc3ccccc32)C1.CCOC(=O)Cl>>CCOC(=O)C1(C(=O)OCC)CCn2c(cc3ccccc32)C1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20100280011A1,CC(C)(C)OC(=O)NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(CO)cc1.O=C(O)C1CCCCC1>>CC(C)(C)OC(=O)NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(COC(=O)C2CCCCC2)cc1,CN(C)c1ccncc1,c1ccncc1,,ClCCCl,,val
US20060128734A1,CCNc1cc(Oc2ccc(N)cc2)ncn1.N[C@@H]1Cc2ccc(Br)cc2C1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCNc1cc(Oc2ccc(NC(=O)N[C@@H]3Cc4ccc(Br)cc4C3)cc2)ncn1,,ClCCl,,CCN(CC)CC,,val
US20040030051A1,CC(C)(C)C1=CC(=C(c2ccccc2)c2ccccc2)C=C1.CC(C)(C)c1ccc2c(c1)Cc1cc(C(C)(C)C)ccc1-2>>CC(C)(C)C1=CCC(C(c2ccccc2)(c2ccccc2)C2c3cc(C(C)(C)C)ccc3-c3ccc(C(C)(C)C)cc32)=C1,,CCCCCC,CCOCC,[Li]CCCC,[Cl-].[NH4+],val
US20120010207A1,CS(N)(=O)=O.O=C(O)c1ccc(Nc2cccc(C(F)(F)F)c2)cc1>>CS(=O)(=O)NC(=O)c1ccc(Nc2cccc(C(F)(F)F)c2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030083500A1,CC(=O)Cl.CCCCc1nc2c(N)nc3cccnc3c2n1CCN>>CCCCc1nc2c(N)nc3cccnc3c2n1CCNC(C)=O,,ClCCl,,,,val
US20100137281A1,CCCc1cc(C(=O)OC)c(N)s1.NCCc1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCc1cc2c(=O)n(CCc3ccccc3)c(=O)[nH]c2s1,,ClCCl,,CCN(CC)CC,,val
US20080119442A1,CC(C)(C)OC(=O)N(CC=CCl)c1ccc2ccc(C#N)cc2c1Br>>CC(C)(C)OC(=O)N1CC(CCl)c2c1ccc1ccc(C#N)cc21,,c1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US20160218303A1,CI.Cc1ccccc1-n1cnc2c(C#N)cccc21>>Cc1ccccc1-n1c[n+](C)c2c(C#N)cccc21.[I-],,CC#N,,,,val
US20090227622A1,Cc1cc(C(C)(C)C)cc(Cl)n1.O=C1CCC(=O)N1Br>>CC(C)(C)c1cc(Cl)nc(CBr)c1,CC(C)(C#N)N=NC(C)(C)C#N,ClC(Cl)(Cl)Cl,,,,val
US20040171643A1,BrCc1ccccc1Br.OC1CCCCC1>>Brc1ccccc1COC1CCCCC1,,CN(C)C=O,,[H-].[Na+],,val
US05985882,CC(=O)OC(C)CCc1cc(Cl)n2nccc2n1.OCc1ccncc1>>CC(O)CCc1cc(OCc2ccncc2)n2nccc2n1,,CN(C)C=O,,[H-].[Na+],,val
US20090270405A1,CCOC(=O)Nc1nc2cnc(Cl)nc2s1.CO>>COc1ncc2nc(N)sc2n1,,CO,,O,C[O-].[Na+],val
US20120028938A1,COC(=O)Cc1c(C)n[nH]c1C.O=Cc1ccc(CBr)cc1>>COC(=O)Cc1c(C)nn(Cc2ccc(C=O)cc2)c1C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US06218376B1,C/C=C/C(=O)OC.COc1cccc(C=O)c1>>COC(=O)C=CC=Cc1cccc(OC)c1,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US04971982,CC1(C)CC(c2ccccn2)c2cc(C(N)=O)ccc2O1.O=C(OO)c1cccc(Cl)c1>>CC1(C)CC(c2cccc[n+]2[O-])c2cc(C(N)=O)ccc2O1,,ClCCl,,,,val
US20040157886A1,O=C(CCl)Nc1ccc([N+](=O)[O-])cc1.c1ccc(CC2CCNCC2)cc1>>O=C(CN1CCC(Cc2ccccc2)CC1)Nc1ccc([N+](=O)[O-])cc1,,CCOCC,,,,val
US20140057895A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccnc(C)c1>>COC(=O)C1CCN(C(=O)OC(C)(C)C)C(C)C1,O=[Pt]=O,CO,,,,val
US20070185133A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.CSc1ncc(Cl)c(C(=O)NNC(=O)Cc2ccccc2)n1>>CSc1ncc(Cl)c(-c2nnc(Cc3ccccc3)s2)n1,,O,c1ccncc1,,,val
US20070254866A1,COc1c(F)c(F)c(N)c2c(=O)c(C(=O)O)c(C)n(C3CC3)c12.NCCNc1ccccn1>>COc1c(NCCNc2ccccn2)c(F)c(N)c2c(=O)c(C(=O)O)c(C)n(C3CC3)c12,,CS(C)=O,O,CCN(CC)CC,[Cl-].[NH4+],val
US20110306636A1,COCCNc1ncc(C#N)cc1Cl.NO>>COCCNc1ncc(C(N)=NO)cc1Cl,,C1CCOC1,,,,val
US20060111347A1,CC(C)(C)OC(=O)N[C@@H]1CCCc2cc(CO)ccc21>>CC(C)(C)OC(=O)N[C@@H]1CCCc2cc(C=O)ccc21,O=[Mn]=O,ClCCl,,,,val
US20070213371A1,COC1(c2ccc(C(F)(F)F)cc2CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)CCN(C(=O)OC(C)(C)C)CC1>>COC1(c2ccc(C(F)(F)F)cc2CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)CCNCC1,,C1COCCO1,,Cl,,val
US06215004B1,CCCC(=O)Cl.CCN(CC)CC.COC(C)(C)C.OCC=CCO>>CCCC(=O)OC/C=C/COC(=O)CCC,CN(C)c1ccncc1,,,,,val
US20140051679A1,NC(=O)c1ccc2[nH]nc(I)c2c1.NC(c1ccccc1F)C1CC1>>O=C(NC(c1ccccc1F)C1CC1)c1ccc2[nH]nc(I)c2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120142717A1,N#CN.OCCc1ccc(Oc2cccc(C(F)(F)F)n2)c(F)c1>>N=C(N)OCCc1ccc(Oc2cccc(C(F)(F)F)n2)c(F)c1,,C1CCOC1,,O=S(=O)(O)C(F)(F)F,,val
US20120040978A1,CCOC(=O)c1nn(Cc2ccc(-c3cccnc3)nc2C)c2ncccc2c1=S.NN[C@@H]1CCCC[C@H]1O>>Cc1ccc(-c2ccc(Cn3nc4c(=O)n([C@@H]5CCCC[C@H]5O)nc-4c4cccnc43)cn2)cn1,Cl[Hg]Cl,CCO,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20100210610A1,COC(=O)Cc1c(C)n(Cc2ccc([N+](=O)[O-])cc2)c2ncccc12>>Cc1c(CC(=O)O)c2cccnc2n1Cc1ccc(N)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US04048311,CC(C)(C)N[SH](=O)=O.CCN.CI.S=C=S>>CSC(=S)NCCS(=O)(=O)NC(C)(C)C,,CCO,,CCN(CC)CC,Cl,val
US20050267105A1,CCOC(=O)c1nc2n(c(=O)c1OCc1ccccc1)CCOC2C>>CC1OCCn2c1nc(C(=O)O)c(OCc1ccccc1)c2=O,,CCCCCC,CCOC(C)=O,,,val
US05418233,N=C(NC(=O)OCc1ccccc1)c1ccc(-c2ncc(C(=O)O)cn2)cc1.O=C(CC1(O)CCNCC1)OCc1ccccc1>>N=C(NC(=O)OCc1ccccc1)c1ccc(-c2ncc(C(=O)N3CCC(O)(CC(=O)OCc4ccccc4)CC3)cn2)cc1,,CN(C)C=O,,CN1CCOCC1,Cl,val
US20070142431A1,NO.O=C(c1ccc(F)cc1)C1CC1>>ON=C(c1ccc(F)cc1)C1CC1,,c1ccncc1,,Cl,,val
US20130289012A1,CC(C)(C)OC(=O)N1C[C@H](NOCc2ccccc2)CC[C@H]1c1ncon1.O=C(Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1C[C@H](N(OCc2ccccc2)C(=O)Cl)CC[C@H]1c1ncon1,,ClCCl,,,,val
US20110201604A1,CCN.COC(=O)c1ccc(Cl)c([N+](=O)[O-])c1>>CCNc1ccc(C(=O)OC)cc1[N+](=O)[O-],,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20080103139A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.COC(=O)C1(N)CCOCC1>>CCOC(=O)C1(NC(=O)OC(C)(C)C)CCOCC1,,C1COCCO1,,Cl,Cl,val
US03940434,O=S(Cl)Cl.OCCc1cccc(C2CCCCC2)c1>>ClCCc1cccc(C2CCCCC2)c1,,O,,c1ccncc1,,val
US05409956,CCOC(=O)C(Cl)SC.O=S(=O)(NCC1Cc2ccccc2C1)c1ccc(Cl)cc1>>CCOC(=O)Cc1ccc2c(c1)CC(CNS(=O)(=O)c1ccc(Cl)cc1)C2,[Zn],CC(=O)O,ClCCl,,,val
US05208247,CCCCCCCCCCCCCCOc1cccc(C(=O)O)c1.O=C(Cl)C(=O)Cl>>CCCCCCCCCCCCCCOc1cccc(C(=O)Cl)c1,,ClCCl,,CN(C)C=O,,val
US20160136145A1,OCCBr.c1ccncc1>>OCC[n+]1ccccc1.[Br-],,CC#N,,,,val
US20140228343A1,BrCC1CO1.Nc1cccc(Br)n1>>Brc1cccc(NCC2CO2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20070270400A1,CC(C)C(=O)Cl.c1ccc(C(c2ccccc2)N2CC(N3CCNCC3)C2)cc1>>CC(C)C(=O)N1CCN(C2CN(C(c3ccccc3)c3ccccc3)C2)CC1,,ClCCl,,CCN(CC)CC,,val
US20040067964A1,CS(=O)(=O)c1ccc2c(c1)cc(C1CCCO1)n2S(=O)(=O)c1ccccc1>>CS(=O)(=O)c1ccc2[nH]c(C3CCCO3)cc2c1,,C1CCOC1,CO,O,[K+].[OH-],val
US20090042892A1,C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(C2CC2)ccc1-c1cc(CC(=O)O)ccc1F>>C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(C2CC2)ccc1-c1cc(CCO)ccc1F,,C1CCOC1,,,,val
US20030139418A1,O=C(Cl)C(=O)Cl.O=C(O)c1ccc(SCc2ccccc2OCc2ccccc2)cc1>>O=C(Cl)c1ccc(SCc2ccccc2OCc2ccccc2)cc1,,ClCCl,,,,val
US05424308,N#CC(C(=O)Nc1ccccc1)C(=O)c1nn(-c2ccccc2)c2c1Cc1ccc(N)cc1-2.O=C(O)CC(O)(CC(=O)O)C(=O)O.c1ccncc1>>CCOC(=O)C(=O)Nc1ccc2c(c1)-c1c(c(C(=O)C(C#N)C(=O)Nc3ccccc3)nn1-c1ccccc1)C2,,CN(C)C=O,,,,val
US20160168156A1,CCOC(=O)c1cnn2ccc(N3CCCC3c3cncc(F)c3)nc12>>O=C(O)c1cnn2ccc(N3CCCC3c3cncc(F)c3)nc12,,CCO,O,[Li+].[OH-],,val
US20020002187A1,COC(=O)[C@@H](O)Cc1ccccc1.Cc1sc2c(Sc3ccccc3)c3ccccc3c(-c3cc(Br)c(O)c(Br)c3)c2c1C>>Cc1sc2c(Sc3ccccc3)c3ccccc3c(-c3cc(Br)c(O[C@H](Cc4ccccc4)C(=O)O)c(Br)c3)c2c1C,,ClC(Cl)Cl,,BrBr,,val
US20150376115A1,CCCCC(CC)C(=O)O.OCCCCCCCCCO>>CCCCC(CC)C(=O)OCCCCCCCCCO,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US04340734,O=C(CBr)C(c1ccccc1)c1ccccc1.S=C1NCC=CCN1>>Br.OC1(C(c2ccccc2)c2ccccc2)CSC2=NCC=CCN21,,CC(C)=O,,,,val
US20090291929A1,CC[C@@H]1Cc2cc(OC)ccc2[C@H]2CC[C@]3(C)C(=O)CC=C3[C@@H]21.C[Si](C)(C)Cl>>CC[C@@H]1Cc2cc(OC)ccc2[C@H]2CC[C@]3(C)C(O[Si](C)(C)C)=CC=C3[C@@H]21,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20130029972A1,C[C@H](NC(=O)CCC(F)(F)F)C(=O)OCc1ccccc1>>C[C@H](NC(=O)CCC(F)(F)F)C(=O)O,[Pd],CO,,,,val
US04612317,CCCCI.C[C@@H]1N[C@H](CO)Cc2c1[nH]c1ccccc21.S=C=S>>CCCCSC(=S)N1[C@H](CO)Cc2c([nH]c3ccccc23)[C@@H]1C,,CN(C)C=O,,CCN(CC)CC,,val
US20130310377A1,O=C1CCC(=O)N1Cl.O=[N+]([O-])c1ccc(-n2nc(C(F)(F)F)cc2C2CC2)cc1>>O=[N+]([O-])c1ccc(-n2nc(C(F)(F)F)c(Cl)c2C2CC2)cc1,,CN(C)C=O,,CCOC(C)=O,,val
US20110288076A1,CC(C)(C)OC(=O)[C@@H]1CCC(=O)N1C(=O)OC(C)(C)C.Cc1cc(F)ccc1CBr>>Cc1cc(F)ccc1C[C@@H]1C[C@@H](C(=O)OC(C)(C)C)N(C(=O)OC(C)(C)C)C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US05593982,CCOC(CBr)OCC.C[C@]12CC[C@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccoc3)CC[C@]12O>>CCOC(CO[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)[C@@H](c5ccoc5)CC[C@]4(O)[C@@H]3CC[C@@H]2C1)OCC,,C1CCOC1,,O,[H-].[Na+],val
US06015774,CCOC(=O)CBr.Cn1c(C(F)(F)F)cnc(-c2cc(O)c(Cl)cc2Cl)c1=O>>CCOC(=O)COc1cc(-c2ncc(C(F)(F)F)n(C)c2=O)c(Cl)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160194316A1,CCO[C@@H]1COC[C@H]1N(CC)c1cc(Cl)cc(C(=O)NCc2c(C)nn(C)c2OC)c1C>>CCO[C@@H]1COC[C@H]1N(CC)c1cc(Cl)cc(C(=O)NCc2c(C)[nH]n(C)c2=O)c1C,,Cl,,,,val
US20110034691A1,CC(C)(C)n1ncc2c1-c1cc(F)c(F)cc1N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)[C@@H]2C1CC1>>O=S(=O)(c1ccc(C(F)(F)F)cc1)N1c2cc(F)c(F)cc2-c2[nH]ncc2[C@H]1C1CC1,,O,,O=CO,,val
US20090291965A1,COC(=O)C(c1ccc(C(=O)OC(C)(C)C)cc1)c1nc2ccccc2o1>>COC(=O)C(c1ccc(C(=O)O)cc1)c1nc2ccccc2o1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050154045A1,Cl.N.O=C(O)c1ccc(-c2ccc(NC(=O)[C@@H]3CN4CCC3CC4)cc2)cc1>>Cl.NC(=O)c1ccc(-c2ccc(NC(=O)[C@H]3CN4CCC3CC4)cc2)cc1,,C1CCOC1,,O=S(Cl)Cl,,val
US06498251B1,COc1cc2c(cc1OC)C(C)N(C(=O)OC(C)(C)C)CC2.O=C1Nc2cccc3c2C1(CCCCBr)CCC3>>COc1cc2c(cc1OC)C(C)N(CCCCC13CCCc4cccc(c41)NC3=O)CC2,,CO,Cl,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20150141400A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(CCN[C@H]1CCCN(C(=O)OCc2ccccc2)C1)C(=O)OC(C)(C)C>>CN(CCN(C(=O)OC(C)(C)C)[C@H]1CCCN(C(=O)OCc2ccccc2)C1)C(=O)OC(C)(C)C,,C1CCOC1,,CCN(CC)CC,,val
US04564610,CCO.CCOC(=O)c1ncc2[nH]c3ccc(C(=O)Cl)cc3c2n1>>CCOC(=O)c1ccc2[nH]c3cnc(C(=O)OCC)nc3c2c1,,CCO,,C1CCOC1,CCN(CC)CC,val
US20140023691A1,CC(C(=O)CCCCCc1ccccc1)[N+](=O)[O-].N#CN>>Cc1[nH]c(N)nc1CCCCCc1ccccc1,[Pd],,,Cl,,val
US20120214766A1,CCOC(=O)c1nn(-c2cc(Br)ccn2)c2c1C[C@@H]1C[C@H]21>>O=C(O)c1nn(-c2cc(Br)ccn2)c2c1C[C@@H]1C[C@H]21,,C1CCOC1,CO,[Na+].[OH-],,val
US20160152599A1,Cc1cc(C(=O)N(c2ccccc2)c2ccc(O[Si](C)(C)C(C)(C)C)cc2)cn1-c1cc(C(F)(F)F)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN(C)C>>Cc1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)cn1-c1cc(C(F)(F)F)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN(C)C,,CO,ClCCl,[K+].[OH-],,val
US04382892,BrCCBr.O=[N+]([O-])c1ccc(F)c(F)c1O>>O=[N+]([O-])c1ccc(F)c(F)c1OCCBr,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060211680A1,COCCNS(=O)(=O)c1cccc(C(=O)O)c1>>COCCNS(=O)(=O)c1cccc(CO)c1,,C1CCOC1,,CO,Cl,val
US20140051679A1,NC(=O)c1ccc2[nH]nc(I)c2c1.NC(c1ccccc1)C1CCOCC1>>O=C(NC(c1ccccc1)C1CCOCC1)c1ccc2[nH]nc(I)c2c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US08377942B2,NO.O=Cc1ccc(Br)c2ccccc12>>ON=Cc1ccc(Br)c2ccccc12,,CO,,,,val
US20150329538A1,CC(C)(C)OC(=O)N1CCC[C@@H](Oc2ccc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)C1.O=C(O)C(F)(F)F>>O=C(O)C(F)(F)F.O=C1NCCc2[nH]c(-c3cccc4ccc(O[C@@H]5CCCNC5)nc34)cc21,,ClCCl,,,,val
US20080269210A1,Cc1c(-c2cccc(O)c2)sc2c(N3CCOCC3)nc(Cl)nc12.OCCCl>>Cc1c(-c2cccc(OCCO)c2)sc2c(N3CCOCC3)nc(Cl)nc12,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140155373A1,COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc(CNc3ccccc3F)cc2)cc1OC.O=C(Cl)O[C@H]1CN2CCC1CC2>>COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc(CN(C(=O)O[C@H]3CN4CCC3CC4)c3ccccc3F)cc2)cc1OC,,CC#N,,Cl,c1ccncc1,val
US06476030B1,Cn1ncnc1CCl.Oc1nn2c(-c3ccccc3F)nncc2c1I>>Cn1ncnc1COc1nn2c(-c3ccccc3F)nncc2c1I,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20090075995A1,CC(=O)CC(=O)c1ccccc1Cl.COC(OC)N(C)C>>CC(=O)C(=CN(C)C)C(=O)c1ccccc1Cl,,Cc1ccccc1,,,,val
US20050165057A1,CC(C)c1cc(NC(=O)OC(C)(C)C)cc(C(C)C)c1NC(=O)NCC1(c2cccc(O)c2)CCN(c2ccccc2)CC1.O=C1c2ccccc2C(=O)N1CCCBr>>CC(C)c1cc(NC(=O)OC(C)(C)C)cc(C(C)C)c1NC(=O)NCC1(c2cccc(OCCCN3C(=O)c4ccccc4C3=O)c2)CCN(c2ccccc2)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04880802,CCOC(=O)OCC.NCC1CCNCC1>>CCOC(=O)NCC1CCNCC1,CN(C)c1ccncc1,CO,,,,val
US20120184542A1,CC(C)(C)OC(=O)N1CCC(C(=O)O)(c2ccccc2)CC1.N>>CC(C)(C)OC(=O)N1CCC(C(N)=O)(c2ccccc2)CC1,,CN(C)C=O,CO,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110028442A1,CC(C)(C)OC(=O)NCCc1cccc(NC(=O)NCc2ccccc2)c1>>NCCc1cccc(NC(=O)NCc2ccccc2)c1,,C1COCCO1,,,,val
US20070249722A1,CCOC(=O)C(N)C(C(F)(F)F)C(F)(F)F.O=S(=O)(Cl)c1ccc(Cl)c(F)c1>>CCOC(=O)C(NS(=O)(=O)c1ccc(Cl)c(F)c1)C(C(F)(F)F)C(F)(F)F,,CC(Cl)Cl,,c1ccncc1,,val
US20130012518A1,Cc1ccc([N+](=O)[O-])cc1N1CCc2nc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)ncc2C1=O>>Cc1ccc(N)cc1N1CCc2nc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)ncc2C1=O,[Pd],CO,,C1CCOC1,,val
US20050107606A1,CC(C)CN1CCCC1=O.CS(=O)(=O)O.O=Cc1cc(Br)ccc1F>>CC(C)CN(CCCC(=O)O)c1ccc(Br)cc1C=O,,CS(C)=O,O,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20140005164A1,COCCNc1ccc2c(c1)n(C[C@@H]1CC[C@@H](C(=O)OC)CC1)c(=O)n2C>>COCCNc1ccc2c(c1)n(C[C@@H]1CC[C@@H](C(=O)O)CC1)c(=O)n2C,,C1CCOC1,O,[Li+].[OH-],,val
US05589474,O=C1NC2=C(C=CCC2)Sc2c1cccc2C(F)(F)F.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>FC(F)(F)c1cccc2c1Sc1ccccc1NC2=S,,c1ccncc1,,O,,val
US20080167307A1,COC(=O)c1cc(I)ccc1OCCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1.OB(O)Oc1ccc(F)cc1>>COC(=O)c1cc(-c2ccc(F)cc2)ccc1OCCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=C([O-])[O-].[Na+].[Na+],val
US20050054658A1,Cc1ccc(CCO[C@H]2CC[C@H](NC(=O)OCc3ccccc3)C2)cc1>>Cc1ccc(CCO[C@H]2CC[C@H](N)C2)cc1,[Pd],CCO,,[H][H],,val
US20160068515A1,CC(C)c1nc(C2CCN(c3ncc(B4OC(C)(C)C(C)(C)O4)cc3C#N)CC2)no1.CCCn1ncn(-c2ccc(Br)cc2F)c1=O>>CCCn1ncn(-c2ccc(-c3cnc(N4CCC(c5noc(C(C)C)n5)CC4)c(C#N)c3)cc2F)c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20100286116A1,Cc1onc(-c2ccccn2)c1CO.O=S(Cl)Cl>>Cc1onc(-c2ccccn2)c1CCl,,ClCCl,,,,val
US05209771,NS(=O)(=O)c1ccccc1C(=O)OC1COC1.O=C(Oc1ccccc1)Oc1ccccc1>>O=C(NS(=O)(=O)c1ccccc1C(=O)OC1COC1)Oc1ccccc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20070155744A1,CC#N.CI.CN(Cc1ccccc1)C(=O)c1cc(C(=O)NCc2ccc(F)cc2)c(O)c(O)n1>>COc1c(C(=O)NCc2ccc(F)cc2)cc(C(=O)N(C)Cc2ccccc2)n(C)c1=O,,C1CCOC1,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US05925655,O=C(NC[C@H](NS(=O)(=O)c1ccccc1)C(=O)O)c1ccc2c(c1)C(=O)N(CCNc1ncccn1)C2>>O=C(NC[C@H](NS(=O)(=O)c1ccccc1)C(=O)O)c1ccc2c(c1)C(=O)N(CCNC1=NCCCN1)C2,[Pd],CC(=O)O,,O=C(O)C(F)(F)F,,val
US20160102059A1,CCO[PH](C)=O.Cc1cc([N+](=O)[O-])ccc1I>>CCOP(C)(=O)c1ccc([N+](=O)[O-])cc1C,,Cc1ccccc1,ClCCl,CCN(C(C)C)C(C)C,,val
US20160255837A1,COc1ccc(CCl)cc1.Oc1cnc(Cl)c(Cl)c1>>COc1ccc(COc2cnc(Cl)c(Cl)c2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080275244A1,Cc1ccc(S(=O)(=O)O)cc1.Nc1ncccc1-c1cc(Cc2ccc(COc3ccccn3)cc2)no1>>Cc1ccc(S(=O)(=O)O)cc1.Nc1ncccc1-c1cc(Cc2ccc(COc3ccccn3)cc2)no1,,CO,,,,val
US20130274241A1,COC(=O)c1ccc(-n2cc(-c3n[nH]c4ccccc34)nn2)cc1OC>>COc1cc(-n2cc(-c3n[nH]c4ccccc34)nn2)ccc1C(=O)O,,CO,,[Na+].[OH-],,val
US20160096827A1,COc1cc(C#N)cc(B2OC(C)(C)C(C)(C)O2)c1.Clc1ncnc(Nc2ccc(N3CCN(C4COC4)CC3)cc2)n1>>COc1cc(C#N)cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)c1,,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20020035102A1,CC(C)(C)[Si](C)(C)OCc1cccc(C(=C2CN(C(c3ccccc3)c3ccccc3)C2)S(C)(=O)=O)c1>>CS(=O)(=O)C(=C1CN(C(c2ccccc2)c2ccccc2)C1)c1cccc(CO)c1,,C1CCOC1,CCOC(C)=O,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20150297596A1,COc1cc(CNC(=O)c2cc(CO[Si](C)(C)C(C)(C)C)nc(C)n2)ccc1F>>COc1cc(CNC(=O)c2cc(CO)nc(C)n2)ccc1F,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20110059954A1,Cc1cc(C(=O)c2cc(Cl)ncn2)cc2oc(=O)n(C)c12.O=c1[nH]c(-c2ccccc2)nn1C1CCNCC1>>Cc1cc(C(=O)c2cc(N3CCC(n4nc(-c5ccccc5)[nH]c4=O)CC3)ncn2)cc2oc(=O)n(C)c12,,CN(C)C=O,CO,CCN(C(C)C)C(C)C,,val
US20060264493A1,CSC(SC)=C1CCc2c(n(C3CCCCO3)c3ccccc23)C1=O.NN>>CSc1n[nH]c2c1CCc1c-2[nH]c2ccccc12,,C1COCCO1,,CCOCC,O,val
US05270464,COC(=O)C(C)N.Cc1ccc2[nH]c(=O)oc(=O)c2c1>>Cc1ccc2c(c1)C(=O)NC(C)C(=O)N2,,c1ccncc1,,Cl,,val
US20160108039A1,COCC1NCC2CCN2C1=O.O=C(Cl)OCc1ccccc1>>COCC1C(=O)N2CCC2CN1C(=O)OCc1ccccc1,,C1CCOC1,Cc1ccccc1,CCN(CC)CC,,val
US20070173506A1,CC(C)(C)OC(=O)Nc1nccs1.CCCC[Sn](Cl)(CCCC)CCCC>>CCCC[Sn](CCCC)(CCCC)c1cnc(NC(=O)OC(C)(C)C)s1,,C1CCOC1,,[Li]CCCC,,val
US20080108614A1,C1COCCN1.COc1cc2c(=O)[nH]c(Cl)nc2c(OC)c1OC>>COc1cc2c(=O)[nH]c(N3CCOCC3)nc2c(OC)c1OC,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20100125089A1,CC(N)(C#N)Cn1nc2c(Cl)cc(Cl)c(Cl)c2n1.O=C(Cl)c1ccc(OC(F)(F)C(F)F)cc1>>CC(C#N)(Cn1nc2c(Cl)cc(Cl)c(Cl)c2n1)NC(=O)c1ccc(OC(F)(F)C(F)F)cc1,,C1CCOC1,,,,val
US20060142265A1,C=CC(=O)Cl.CCCc1c(CNC)oc2ccccc12>>C=CC(=O)N(C)Cc1oc2ccccc2c1CCC,,ClCCl,,CCN(CC)CC,,val
US20050032829A1,CCOCc1nc2c(c(C)c(C)n3nnnc23)n1CCN.O=C=Nc1ccccc1>>CCOCc1nc2c(c(C)c(C)n3nnnc23)n1CCNC(=O)Nc1ccccc1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20110190365A1,COC(=O)c1ccc(N)cc1C.O=N[O-]>>COC(=O)c1ccc(NN)cc1C,,Cl,O,Cl[Sn]Cl,,val
US20020065269A1,COc1ccc(S(=O)(=O)N2CC=CCC(C(=O)OCc3ccccc3)C2C(=O)OC(C)(C)C)cc1>>COc1ccc(S(=O)(=O)N2CCCCC(C(=O)O)C2C(=O)OC(C)(C)C)cc1,[Pd],C1COCCO1,CO,,,val
US20090326009A1,CC1=CC(C)(C)Nc2ccc3c(c21)c(=O)oc1c(O)cccc13.CI>>COc1cccc2c1oc(=O)c1c3c(ccc12)NC(C)(C)C=C3C,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20150225439A1,CC(C)(C)OC(=O)NCCOCCN(CCOCCO)CC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NCCOCCN(CCOCCO)CC(=O)O,[Pd],CO,ClCCl,,,val
US05250528,O=NN1CCN(C(=O)c2cccs2)CC1>>NN1CCN(C(=O)c2cccs2)CC1,[Zn],CC(=O)O,O,[Na+].[OH-],,val
US20150011551A1,COc1ccc(Br)cc1.OB(O)c1ccncc1>>COc1ccc(-c2ccncc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05504087,COc1ccc(O)c(C(C)(C)C)c1.ClCC1CO1>>COc1ccc(OCC2CO2)c(C(C)(C)C)c1,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080096860A1,COc1ccc(CN(c2cc(OC)nc(S(=O)(=O)Cc3cccc(F)c3F)n2)S(=O)(=O)N2CCC2)cc1.SCCc1ccccc1>>COc1ccc(CN(c2cc(OC)nc(SCCc3ccccc3)n2)S(=O)(=O)N2CCC2)cc1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20130150343A1,C=O.CC1(C)CN[C@H](C(=O)O)C1>>CN1CC(C)(C)C[C@H]1C(=O)O,[Pd],,,CCN(C(C)C)C(C)C,Cl,val
US20050261177A1,CCOC(=O)c1ccc(N2CCC(=O)CC2)cc1.COC(OC)N(C)C>>CCOC(=O)c1ccc(N2CCC(=O)/C(=C/N(C)C)C2)cc1,,CCCCCC,,,,val
US20080097108A1,CCOC(=O)CBr.COc1ccc2c3c([nH]c2c1)CCCC3=O>>CCOC(=O)Cn1c2c(c3ccc(OC)cc31)C(=O)CCC2,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110071175A1,COC(=O)CBr.Cc1cc2cc(Cl)ccc2n1CC(=O)O>>COC(=O)Cn1c(C)cc2cc(Cl)ccc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060194842A1,COC(=O)C(C)(C)c1ccc(F)cc1[N+](=O)[O-]>>CC1(C)C(=O)Nc2cc(F)ccc21,[Fe],CC(=O)O,,,,val
US20120029002A1,COc1ccc(Cn2nc(O)c3ccccc32)cc1.O=[N+]([O-])c1ccc(F)c(F)c1>>COc1ccc(Cn2nc(Oc3ccc([N+](=O)[O-])cc3F)c3ccccc32)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20080009488A1,CI.COC(=O)c1ccccc1C(=O)c1ccc(N)c(NC(=O)OC(C)(C)C)c1>>CN(C(=O)OC(C)(C)C)c1cc(C(=O)c2ccccc2C(=O)O)ccc1N,,C1CCOC1,,Cl,[H-].[Na+],val
US03953596,C1CC2CNCC1O2.CCCCCCC(=O)Cl>>CCCCCCC(=O)N1CC2CCC(C1)O2,,O,,Cl,[Na+].[OH-],val
US20100168418A1,CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCN(CCn2c(=O)cc(Cl)c3ccc(F)cc32)CC1.Cl>>Cl.O=c1cc(Cl)c2ccc(F)cc2n1CCN1CCC(NCc2ccc3c(c2)OCCO3)CC1,,CCOC(C)=O,,,,val
US04826862,Nc1ccc(C(=O)c2ccc(F)cc2)cc1[N+](=O)[O-]>>Nc1ccc(C(O)c2ccc(F)cc2)cc1[N+](=O)[O-],,CC(=O)O,,CO,[BH4-].[Na+],val
US05661153,CN.Cn1c(=O)cc(Cl)n(-c2ccccc2)c1=O>>CNc1cc(=O)n(C)c(=O)n1-c1ccccc1,,CC(C)O,,,,val
US20110105781A1,CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCO.Cc1ccc(S(=O)(=O)Cl)cc1>>CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCOS(=O)(=O)c1ccc(C)cc1,,c1ccncc1,,,,val
US20100105906A1,COC(=O)C1CCNc2ccccc21.O=C(Cl)c1cc(F)cnc1Oc1cc(Cl)ccc1Cl>>COC(=O)C1CCN(C(=O)c2cc(F)cnc2Oc2cc(Cl)ccc2Cl)c2ccccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US05340910,CC(O)c1ccc(N)cc1.Cn1c(=O)c(C#N)c2c3c(c(Br)ccc31)C(=O)c1ccccc1-2>>Cn1c(=O)c(C#N)c2c3c(c(Nc4ccc(CCO)cc4)ccc31)C(=O)c1ccccc1-2,,CC(C)O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20140336377A1,COC(=O)c1cnc(OCC(F)(F)F)c(C)c1.O=C1CCC(=O)N1Br>>COC(=O)c1cnc(OCC(F)(F)F)c(CBr)c1,CC(C)(C#N)N=NC(C)(C)C#N,CC(Cl)Cl,,O,,val
US04018817,CCCN.O=C(Cl)C1CCc2cc(C3CCCCC3)c(Cl)cc21>>CCCNC(=O)C1CCc2cc(C3CCCCC3)c(Cl)cc21,,c1ccccc1,,,,val
US20080076777A1,CC(C)(C)OC(=O)N1CCNCC1.Nc1cnc(Cl)nc1Cl>>CC(C)(C)OC(=O)N1CCN(c2nc(Cl)ncc2N)CC1,,CS(C)=O,,CCN(CC)CC,,val
US20130317031A1,CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)NNC(=O)/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1.O=C(O)C(F)(F)F>>CC(C)[C@@H](N)C(=O)NNC(=O)/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20090137549A1,CCOC(=O)c1ccccc1NS(C)(=O)=O>>CS(=O)(=O)Nc1ccccc1C(=O)O,,C1CCOC1,,[Li+].[OH-],,val
US20110021520A1,CC(C)(C)OC(=O)NC1=NC(CF)(c2cccc(NC(=O)c3ccc(Br)cn3)c2)COC1>>NC1=NC(CF)(c2cccc(NC(=O)c3ccc(Br)cn3)c2)COC1,,CO,Cl,,,val
US20060079687A1,CCCNCc1cc(-c2ccccc2CCNS(=O)(=O)c2ccccc2)ccc1N.N#CBr>>CCCN1Cc2cc(-c3ccccc3CCNS(=O)(=O)c3ccccc3)ccc2N=C1N,,CCO,,,,val
US05068325,ClCC=Cc1ccc2ccccc2c1.Nc1nc2c(s1)CCNCC2>>Nc1nc2c(s1)CCN(CC=Cc1ccc3ccccc3c1)CC2,,ClC(Cl)Cl,,,,val
US20020019424A1,Cc1ccc(S(=O)(=O)N2C(CCCCl)CCC2c2ccc(F)cc2)cc1.c1nc[nH]n1>>Cc1ccc(S(=O)(=O)N2C(CCCn3cncn3)CCC2c2ccc(F)cc2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20130158041A1,CCI.O=Cc1cnc2ccc(Cl)cc2c1>>CCOc1cnc2ccc(Cl)cc2c1,,CN(C)C=O,ClCCl,N#N,O=C([O-])[O-].[K+].[K+],val
US20040142850A1,CCOC(=O)Nc1c([N+](=O)[O-])cc(Br)cc1C(F)(F)F.COc1ccc(CO)c(OC)c1>>CCOC(=O)N(Cc1ccc(OC)cc1OC)c1c([N+](=O)[O-])cc(Br)cc1C(F)(F)F,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05663437,Nc1cc([N+](=O)[O-])ccc1-c1ccc([N+](=O)[O-])cc1.O=C(Cl)c1ccccc1>>O=C(N=C1CC([N+](=O)[O-])=CC=C1c1ccc([N+](=O)[O-])cc1)c1ccccc1,CN(C)c1ccncc1,CN1CCCC1=O,,,,val
US05476933,C/C=C/C=O.CC(C)(C)[Si](C)(C)ON>>CC=CC=NO[Si](C)(C)C(C)(C)C,,ClCCl,,,,val
US20070066624A1,CS(=O)(=O)Cl.Cc1nc(Oc2ccc(N)cc2)ccc1CN1CCC(N2C(=O)OC[C@H]2c2ccccc2)CC1>>Cc1nc(Oc2ccc(NS(C)(=O)=O)cc2)ccc1CN1CCC(N2C(=O)OC[C@H]2c2ccccc2)CC1,,ClCCl,,CCN(CC)CC,,val
US04788195,COc1ccc(Nc2nccc(-c3cccnc3)n2)cc1>>Oc1ccc(Nc2nccc(-c3cccnc3)n2)cc1,,Br,,,,val
US20060094724A1,CC(C)(C)OC(=O)NCC=O.COC(=O)[C@@H]1CC[C@@H](N)CC1>>COC(=O)[C@@H]1CC[C@@H](NCCNC(=O)OC(C)(C)C)CC1,,CCN(CC)CC,ClCCl,Cl,O=C([O-])O.[Na+],val
US20100278833A1,COC(=O)c1sc(-n2cnc3cnccc32)cc1OCc1ccccc1C#N.N>>N#Cc1ccccc1COc1cc(-n2cnc3cnccc32)sc1C(N)=O,,CO,,,,val
US20110245220A1,C1CCOC1.COC(OC)c1ccc(Br)cc1.O=C1COC1>>COC(OC)c1ccc(C2(O)CCC2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20150119392A1,CC(=O)Cc1cc(N)c(F)cc1Br.CSc1ncc(C=O)c(N)n1>>CSc1ncc2cc(-c3cc(N)c(F)cc3Br)c(C)nc2n1,,CCO,,C,C[O-].[Na+],val
US20030216325A1,CC(C)(C)OC(=O)N1CC(c2ccccc2)C[C@H]1C(=O)O>>CC(C)(C)OC(=O)N1CC(C2CCCCC2)C[C@H]1C(=O)O,[Rh],CO,,,,val
US20100113547A1,C=CCOCC1(c2ccccc2)NC(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C1=O.CI>>C=CCOCC1(c2ccccc2)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)N1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060030719A1,CCCCCC=C1CC(C)OC1=O>>CCCCCC[C@H]1C[C@@H](C)OC1=O,[Pd],CO,,CCO,,val
US20110269700A1,C#CCO.CCOc1ccc(Cc2cc([C@@H]3O[C@H](CN=[N+]=[N-])[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1>>CCOc1ccc(Cc2cc([C@@H]3O[C@H](Cn4cc(CO)nn4)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1,,Cc1ccccc1,,,,val
US20150175557A1,CC(C)(C)OC(=O)NC1CC(N)C1(C)C.N#Cc1cnc(NCCc2cccc(Cl)c2)nc1Cl>>CC1(C)[C@@H](N)C[C@@H]1Nc1nc(NCCc2cccc(Cl)c2)ncc1C#N,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US20020103178A1,C[C@]12CC[C@@H]3c4cc(C56CC7CC(CC(C7)C5)C6)c(O)cc4CC[C@H]3[C@@H]1CCC2=O>>C[C@]12CC[C@@H]3c4cc(C56CC7CC(CC(C7)C5)C6)c(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O,,CO,,CCO,[BH4-].[Na+],val
US20140329794A1,COC(=O)c1cccc(-c2ccncc2)c1>>O=C(O)c1cccc(-c2ccncc2)c1,,CO,,[Na+].[OH-],,val
US04791209,C=CCBr.Oc1cc(Cl)c2c(-c3ccccc3F)noc2c1>>C=CCOc1cc(Cl)c2c(-c3ccccc3F)noc2c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US04957916,Cc1nc2ccccn2c(=O)c1CCCl.NNc1ccccc1.O=C(c1ccccc1F)N1CCNCC1>>Cc1nc2ccccn2c(=O)c1CCN1CCN(C(=NNc2ccccc2)c2ccccc2F)CC1,,CC(=O)CC(C)C,,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US20150025068A1,COC(=O)c1ccc(N)cc1O.COc1ccc(S(=O)(=O)Cl)cc1Br>>COC(=O)c1ccc(NS(=O)(=O)c2ccc(OC)c(Br)c2)cc1O,,CC#N,CCOC(C)=O,O,c1ccncc1,val
US20160272617A1,Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3[nH]c(-c4ccccn4)nc3c2)cc1.Cl>>Cc1cc(C(=O)NC2CCNCC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc3[nH]c(-c4ccccn4)nc3c2)cc1.Cl,,C1CCOC1,C1COCCO1,,,val
US20070032530A1,Cc1nc(-c2ccc(OC(F)(F)F)cc2)ccc1CCl.Oc1ccc(CCCCn2ccnn2)cc1>>Cc1nc(-c2ccc(OC(F)(F)F)cc2)ccc1COc1ccc(CCCCn2ccnn2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US04225609,O=C(O)c1ccc(CCCC2SCC(=O)N2CC#CC2(O)CCCCC2)cc1>>O=C(O)c1ccc(CCCC2SCC(=O)N2C/C=C\C2(O)CCCCC2)cc1,[Pd],CCOC(C)=O,,[H][H],,val
US20070049618A1,NCc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O.O=C=Nc1ccccc1>>O=C1CCC(N2Cc3c(CNC(=O)Nc4ccccc4)cccc3C2=O)C(=O)N1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20040014746A1,NC[C@H]1CN(c2ccc(C3=NNC(=O)CS3)c(F)c2)C(=O)O1.O=Cc1ccc(C=CC(=O)O)cc1>>O=Cc1ccc(C=CC(=O)NC[C@H]2CN(c3ccc(C4=NNC(=O)CS4)c(F)c3)C(=O)O2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140031360A1,CC(C)(C)OC(=O)N1CCC2(CC2)[C@@H](Oc2cncc(-c3nn(C4CCCCO4)c4ccc(C5=CCOCC5)cc34)n2)C1>>CC(C)(C)OC(=O)N1CCC2(CC2)[C@@H](Oc2cncc(-c3nn(C4CCCCO4)c4ccc(C5CCOCC5)cc34)n2)C1,[Pd],CCO,,,,val
US20100105655A1,COc1cc(F)ccc1[N+](=O)[O-].OCC(CO)N1CCNCC1>>COc1cc(N2CCN(C(CO)CO)CC2)ccc1[N+](=O)[O-],,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,,val
US20150094328A1,Cc1ccnc2c(C(=O)N[C@H]3CCCC[C@@H]3O)c[nH]c12.ClCc1ccc(Cl)cn1>>Cc1ccnc2c(C(=O)N[C@H]3CCCC[C@@H]3O)cn(Cc3ccc(Cl)cn3)c12,,CCOC(C)=O,CN(C)C=O,[I-].[Na+],O=C([O-])[O-].[Cs+].[Cs+],val
US20080207715A1,C[Si](C)(C)N=[N+]=[N-].NCCCn1ccnc1.O=Cc1ccc2[nH]ccc2c1.[C-]#[N+]Cc1ccc(Cl)cc1>>Clc1ccc(Cn2nnnc2C(NCCCn2ccnc2)c2ccc3[nH]ccc3c2)cc1,,CO,,,,val
US20020173646A1,NCCO.O=C1COCC(=O)O1>>O=C1COCC(=O)N1CCO,,c1ccncc1,,,,val
US20120208815A1,CC(C)(C)OC(=O)N1CCNCC1.O=C(c1ccccc1)c1ccc(Cl)c([N+](=O)[O-])c1>>CC(C)(C)OC(=O)N1CCN(c2ccc(C(=O)c3ccccc3)cc2[N+](=O)[O-])CC1,,CN1CCCC1=O,,,,val
US20060137207A1,CC(=O)c1ccc(I)cc1O.COc1cc(C=O)cc(OC)c1OC>>COc1cc(C=CC(=O)c2ccc(I)cc2O)cc(OC)c1OC,,CCO,O,Cl,[K+].[OH-],val
US04064125,CN(C)CCCOc1ccc(C=O)cc1.NCCc1ccccc1>>CN(C)CCCOc1ccc(C=NCCc2ccccc2)cc1,,Cc1ccccc1,,,,val
US04323570,O=[N+]([O-])c1c(Cl)nc(C2CC2)nc1Cl>>Nc1c(Cl)nc(C2CC2)nc1Cl,[Ni],CCO,,,,val
US20110190341A1,CC(C)(C)OC(=O)NC(C)(C)C1CCC(=O)CC1>>CC(C)(C)OC(=O)NC(C)(C)C1CCC(O)CC1,,CCO,,[BH4-].[Na+],,val
US20150238601A1,CC1(C)OB(c2cccc(OCC(=O)NC3CC3)c2)OC1(C)C.Cc1cnc(Cl)nc1N(C(=O)OC(C)(C)C)c1ccc2c(cnn2C(=O)OC(C)(C)C)c1>>Cc1cnc(-c2cccc(OCC(=O)NC3CC3)c2)nc1N(C(=O)OC(C)(C)C)c1ccc2c(cnn2C(=O)OC(C)(C)C)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,[Cs+].[F-],,val
US20060178373A1,CC(C)NCC(O)COc1ccc2c(=O)cc(-c3ccc(OCc4ccccc4)c(OCc4ccccc4)c3)oc2c1>>CC(C)NCC(O)COc1ccc2c(=O)cc(-c3ccc(O)c(O)c3)oc2c1,[Pd],CO,,,,val
US05665754,CCOC=O.COC(=O)[C@@H]1CNC[C@H]1c1ccc(OC)c(OC2CCCC2)c1>>COC(=O)[C@@H]1CN(C=O)C[C@H]1c1ccc(OC)c(OC2CCCC2)c1,,CCOCC,,,,val
US20100317651A1,CI.Clc1cncc(NC2CCC2)n1>>CN(c1cncc(Cl)n1)C1CCC1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US05574040,CC(=O)c1cccc(Nc2cc(C)nc(N)n2)c1.CI>>CC(=O)c1cccc(Nc2cc(C)[n+](C)c(N)n2)c1.[I-],,CC(C)=O,,,,val
US20080171772A1,CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(O)cc2n1Cc1ccccc1.CCCI>>CCCOc1ccc2c(C(=O)NCc3ccc(F)c(F)c3)c(C(C)C)n(Cc3ccccc3)c2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060241142A1,ClCCNCCCl.N#CCc1ccc(F)cc1>>N#CC1(c2ccc(F)cc2)CCNCC1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20090312381A1,C=CCNC(=O)NNC(=O)c1ccc(Cl)cc1>>C=CCn1c(-c2ccc(Cl)cc2)n[nH]c1=O,,[Na+],[OH-],Cl,,val
US20100041638A1,CC(C)(C)OC(=O)N1CCN(CCCc2ccc(Br)cc2)CC1.CC1(C)OBOC1(C)C>>CC(C)(C)OC(=O)N1CCN(CCCc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1,,CC#N,,CCN(CC)CC,,val
US06372740B1,CNc1nc(-c2ccccc2)ncc1C(=O)O.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cn1c(=O)[nH]c2cnc(-c3ccccc3)nc21,,CCN(CC)CC,,CN(C)C=O,,val
US20050043354A1,C[Si](C)(C)CN.Cc1cc(F)ccc1C=O>>Cc1cc(F)ccc1C=NC[Si](C)(C)C,,Cc1ccccc1,,,,val
US20100125066A1,CC(=O)Cl.CC(C)O[C@@H]1CC[C@@H](c2nnc3n2-c2ccc(Cl)cc2CNC3)CC1>>CC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2[C@@H]2CC[C@@H](OC(C)C)CC2)C1,,ClCCl,,CCN(CC)CC,Cl,val
US06291475B1,COC(=O)CCCOc1ccc(C#N)cc1>>N#Cc1ccc(OCCCCO)cc1,,CCOCC,,CO,[BH4-].[Li+],val
US20100016337A1,CC(C)(C)OC(=O)CBr.Oc1nc(-c2ccc(F)cc2)cs1>>CC(C)(C)OC(=O)COc1nc(-c2ccc(F)cc2)cs1,,CN(C)C=O,,[H-].[Na+],,val
US20140213571A1,BrBr.COc1ncccc1C(=O)O>>COc1ncc(Br)cc1C(=O)O,,O,,,,val
US20160214956A1,CCOC(=O)c1cnn(-c2cccc(-c3ccccc3OCc3ccc(OCCOC)cc3)n2)c1C(F)(F)F>>COCCOc1ccc(COc2ccccc2-c2cccc(-n3ncc(C(=O)O)c3C(F)(F)F)n2)cc1,,CCO,,[Na+].[OH-],,val
US20100160322A1,C1CNCCN1.CNc1ncc(Oc2cc(F)ccc2C(=O)OC)cc1Cl>>CNc1ncc(Oc2cc(N3CCNCC3)ccc2C(=O)OC)cc1Cl,,CCOC(C)=O,CS(C)=O,,,val
US20130059832A1,Cc1ccc(-c2noc(CC3CN(C(=O)OC(C)(C)C)C3)n2)cc1NC(=O)c1cnc2ccccn12>>Cc1ccc(-c2noc(CC3CNC3)n2)cc1NC(=O)c1cnc2ccccn12,,O=C(O)C(F)(F)F,,,,val
US20080004309A1,CCOC(=O)c1ncc2c(c1O)c(Br)c(Br)n2-c1ccc(F)cc1.O=C1CCC(=O)N1Br>>CCOC(=O)c1nc(Br)c2c(c1O)c(Br)c(Br)n2-c1ccc(F)cc1,,CC#N,,,,val
US20090131414A1,COCCO.Nc1nc(-n2cncn2)c2nc(Cl)ccc2n1>>COCCOc1nc(N)nc2ccc(Cl)nc12,,ClCCl,,CC(C)(C)[O-].[K+],,val
US20090163506A1,CCOC(CN)OCC.O=Cc1ccccc1F>>CCOC(CN=Cc1ccccc1F)OCC,,O,,CCOCC,,val
US06548511B1,C=CCN=C=S.CCOC(=O)/C=C(\N)C(F)(F)F>>C=CCn1c(S)nc(C(F)(F)F)cc1=O,,CN(C)C=O,,[H-].[Na+],,val
US20120232074A1,COc1cc2c(Cl)c(C(N)=O)cnc2cc1-c1c(C)noc1C.C[C@@H](N)c1ccccn1>>COc1cc2c(N[C@H](C)c3ccccn3)c(C(N)=O)cnc2cc1-c1c(C)noc1C,,CC#N,,,,val
US20090137561A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.FC(F)Oc1cccc(Br)c1>>CC1(C)OB(c2cccc(OC(F)F)c2)OC1(C)C,,C1COCCO1,,CC(=O)[O-].[K+],,val
US20110183985A1,CON(C)C(=O)c1ccc2cccnc2c1-c1ccccc1F.C[Mg]Br>>CC(=O)c1ccc2cccnc2c1-c1ccccc1F,,C1CCOC1,,,,val
US20040198786A1,Cc1cccc(-c2nc(CO[C@@H]3CCC[C@H](CC=C4SC(=O)NC4=O)C3)c(C)o2)c1>>Cc1cccc(-c2nc(CO[C@@H]3CCC[C@H](CCC4SC(=O)NC4=O)C3)c(C)o2)c1,,CCOC(C)=O,,,,val
US05981533,O=[N+]([O-])c1cccc(-c2n[nH]c3ncnc(Nc4cccc(Cl)c4)c23)c1>>Nc1cccc(-c2n[nH]c3ncnc(Nc4cccc(Cl)c4)c23)c1,[Ni],C1CCOC1,CO,,,val
US20120135350A1,O=C(OC(C(F)(F)F)C(F)(F)S(=O)(=O)[O-])C12CC3CC(CC(C3)C1)C2.O=S1CCCC1.Oc1cccc2ccccc12>>O=C(OC(C(F)(F)F)C(F)(F)S(=O)(=O)[O-])C12CC3CC(CC(C3)C1)C2.Oc1ccc([S+]2CCCC2)c2ccccc12,,CO,,Cl,,val
US20140057937A1,Cc1c(Cl)c(C(F)F)nn1CC(=O)O.Fc1ccc(-n2ncc3c2CCCN3)cc1>>Cc1c(Cl)c(C(F)F)nn1CC(=O)N1CCCc2c1cnn2-c1ccc(F)cc1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070265281A1,C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)c1ccccc1NC(C)C.CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N(CC(=O)O)CC1CCCCC1>>C=C[C@@H]1C[C@]1(NC(=O)CN(CC1CCCC1)C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(=O)NS(=O)(=O)c1ccccc1NC,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070066628A1,CON(C)C(=O)c1ccc(Br)cc1.[Li]c1cccs1>>O=C(c1ccc(Br)cc1)c1cccs1,,C1CCOC1,,[Cl-].[NH4+],,val
US20050009829A1,COCCBr.O=[N+]([O-])c1cccc(O)c1[N+](=O)[O-]>>COCCOc1cccc([N+](=O)[O-])c1[N+](=O)[O-],,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06248866B1,C1=COCCC1.N[C@@H](CCCCN(C[C@H](O)CCNC(=O)OCc1ccccc1)C(=O)OCc1ccccc1)C(=O)O>>N[C@@H](CCCCN(C[C@@H](CCNC(=O)OCc1ccccc1)OC1CCCCO1)C(=O)OCc1ccccc1)C(=O)O,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20070161648A1,CC(C)(C)OC(=O)n1cccc1-c1cccc2c1C(=O)NC2.CI>>CN1Cc2cccc(-c3cccn3C(=O)OC(C)(C)C)c2C1=O,,C1CCOC1,,[H-].[Na+],,val
US05250554,CCCCC(=O)Nc1ccc(C(=O)OC)cc1[N+](=O)[O-].N#Cc1ccccc1-c1ccc(CBr)cc1>>CCCCC(=O)N(Cc1ccc(-c2ccccc2C#N)cc1)c1ccc(C(=O)OC)cc1[N+](=O)[O-],,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04719218,CCOC(=O)Cl.COc1ccc(-c2cn3c(n2)CCC3)cc1.c1ccncc1>>CCOC(=O)N1C=CC(c2c(-c3ccc(OC)cc3)nc3n2CCC3)C=C1,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US20100298316A1,CCN(CC)CC.O=S(=O)(Cl)CCCCl.c1ccc2oc(N3CCN(C4CC4)CC3)nc2c1>>O=S(=O)(CCCCl)NCc1ccc2oc(N3CCN(C4CC4)CC3)nc2c1,,ClCCl,,,,val
US20050131017A1,CC[C@H](C)[C@H](NC(=O)OC)C(=O)N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCC1c2ccccc2-c2ccccc21>>CC[C@H](C)[C@H](NC(=O)OC)C(=O)N[C@@H](Cc1ccccc1)C[C@H](O)[C@@H](N)Cc1ccccc1,,CN(C)C=O,,CCNCC,,val
US20160177013A1,C=CCN=C=O.C=CCNCC=C>>C=CCNC(=O)N(CC=C)CC=C,,ClCCl,,CCN(CC)CC,,val
US20160218303A1,Cc1cc(C)cc(N)c1.N#Cc1cccc(F)c1[N+](=O)[O-]>>Cc1cc(C)cc(Nc2cccc(C#N)c2[N+](=O)[O-])c1,,C1CCOC1,,O,[H-].[Na+],val
US20150225398A1,BrP(Br)Br.O=C(Nc1nc2cccc(-c3ccc(CO)cc3)n2n1)C1CC1>>O=C(Nc1nc2cccc(-c3ccc(CBr)cc3)n2n1)C1CC1,,ClC(Cl)Cl,,,,val
US04810806,COC(F)(F)C(F)(F)C(=O)C(F)(F)C(F)(F)OC.OCCCl>>COC(F)(F)C(F)(F)C1(C(F)(F)C(F)(F)OC)OCCO1,,CCOCC,,O=C([O-])[O-].[K+].[K+],,val
US20080167319A1,Nc1ccc2ccc(=O)[nH]c2n1>>Nc1ccc2ccc(=O)[nH]c2n1,,O,,O=S(=O)(O)O,[Na+].[OH-],val
US20140187553A1,COc1ccc(CNc2nnc(-c3ccc4[nH]cc(I)c4c3)o2)cc1.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1ccc(CNc2nnc(-c3ccc4c(c3)c(I)cn4S(=O)(=O)c3ccc(C)cc3)o2)cc1,,CN(C)C=O,,[H-].[Na+],,val
US06627651B1,Cc1ccc(-c2ccc3c(c2)C=C(C(=O)NC2CCNCC2)CCO3)cc1.O=Cc1ccccc1>>Cc1ccc(-c2ccc3c(c2)C=C(C(=O)NC2CCN(Cc4ccccc4)CC2)CCO3)cc1,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US04886894,CCOC(=O)C(NC(=O)CN)C(=O)OCC.[N-]=C=O>>CCOC(=O)C(NC(=O)CNC(N)=O)C(=O)OCC,,CC(=O)O,,Cl,,val
US05583230,ClCC=Cc1ccccc1.[O-]c1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl>>Clc1c(Cl)c(Cl)c(OCC=Cc2ccccc2)c(Cl)c1Cl,,CCO,,O,,val
US20140051676A1,CC(C)C(=O)O.CN(c1ccccc1)c1nc(N)nc(-c2noc(C3CCC(N)CC3)n2)n1>>CC(C)C(=O)NC1CCC(c2nc(-c3nc(N)nc(N(C)c4ccccc4)n3)no2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20030078426A1,Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccc(OCCc3ccc(N)cc3)cc21.O=C=Nc1ccc([N+](=O)[O-])cc1>>Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccc(OCCc3ccc(NC(=O)Nc4ccc([N+](=O)[O-])cc4)cc3)cc21,,CN(C)C=O,,,,val
US20080051395A1,Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3cccc(F)c3)n2)c1.O=C(Cl)c1c(F)cccc1Cl>>O=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3cccc(F)c3)n2)c1)c1c(F)cccc1Cl,,C1CCOC1,,,,val
US04472400,CCCN=C=O.COC(=O)c1ccccc1N>>CCCNC(=O)Nc1ccccc1C(=O)OC,,ClCCl,,CCN(CC)CC,,val
US06576656B1,CCN(CC)CCN1C(=O)C(=O)c2c1cc(I)cc2C(F)(F)F.Fc1ccccc1Br>>CCN(CC)CCN1C(=O)C(O)(c2ccccc2F)c2c1cc(I)cc2C(F)(F)F,,C1CCOC1,,CCCCCC,[Li]CCCC,val
US20150038438A1,C=C(C)COc1cc2[nH]c(C(=O)OCC)cc2cc1Br.CI>>C=C(C)COc1cc2c(cc1Br)cc(C(=O)OCC)n2C,,CN(C)C=O,O,[H-].[Na+],[Cl-].[NH4+],val
US04801609,CC(=O)SCC(Cc1ccccc1)C(=O)O.COC(=O)[C@@H](N)CSC(C)(C)C>>COC(=O)[C@H](CSC(C)(C)C)NC(=O)C(CSC(C)=O)Cc1ccccc1,,CO,,,,val
US20110190349A1,CC(C)(C)OC(=O)N[C@@H]1COCC[C@H]1N=[N+]=[N-]>>CC(C)(C)OC(=O)N[C@@H]1COCC[C@H]1N,O=[Pt]=O,CO,,,,val
US20090197871A1,CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cc(C)cc(C(=O)O)c1.COc1ccc(CN)cc1Br>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cc(C)cc(C(=O)NCc2ccc(OC)c(Br)c2)c1,,CCOC(C)=O,ClCCl,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20020132842A1,Cl.Clc1nc2ccccc2[nH]1.Nc1c(F)cccc1Cl>>Cl.Fc1cccc(Cl)c1Nc1nc2ccccc2[nH]1,,CCO,,,,val
US05371284,CCCCCCCCCCc1ccc(C(=O)Cl)cc1>>CCCCCCCCCCc1ccc(C=O)cc1,[Pd],C1CCOC1,,Cc1cccc(C)n1,,val
US20110003807A1,CC1(C)OB(C2=CCCCC2)OC1(C)C.CCOC(=O)c1sc(-c2c(C)nn3ccccc23)nc1OS(=O)(=O)C(F)(F)F>>CCOC(=O)c1sc(-c2c(C)nn3ccccc23)nc1C1=CCCCC1,,COCCOC,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US06399627B1,COCC(=O)CC(=O)OC.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC/C(=C/C(=O)OC)OS(=O)(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20130116245A1,CCOC(=O)c1cc2c([nH]1)CCCC2.CCOC(CBr)OCC>>CCOC(=O)c1cc2c(n1CC(OCC)OCC)CCCC2,,CN(C)C=O,,[H-].[Na+],,val
US20120184553A1,COC(=O)c1cc(C(=O)N2CCCCC2)ccc1OCc1ccccc1>>O=C(O)c1cc(C(=O)N2CCCCC2)ccc1OCc1ccccc1,,C1CCOC1,O,Cl,[Li+].[OH-],val
US05364943,COc1ccccc1C=O.Nc1cccnc1-c1ccccc1>>COc1ccccc1CNc1cccnc1-c1ccccc1,,CO,,Cl,[BH3-]C#N.[Na+],val
US20150126449A1,CC(C)(C)OC(=O)N1CCC(c2cc(=O)[nH]c3c4c(-c5ccccc5)cccc4nn23)CC1.Cl>>Cl.O=c1cc(C2CCNCC2)n2nc3cccc(-c4ccccc4)c3c2[nH]1,,C1COCCO1,,,,val
US20030013875A1,CCCCCCN1C(=O)C2C(C1=O)C2(CCC)c1cccc([N+](=O)[O-])c1>>CCCCCCN1CC2C(C1)C2(CCC)c1cccc([N+](=O)[O-])c1,,C1CCOC1,,B,CO,val
US20110003815A1,CC(C)(C)OC(=O)N1CCC(NC(=O)c2ccc(C3(c4ccc(OCc5ccccn5)cc4)CC4CCC3C4)cc2)CC1>>O=C(NC1CCNCC1)c1ccc(C2(c3ccc(OCc4ccccn4)cc3)CC3CCC2C3)cc1,,C1COCCO1,Cl,O,,val
US20080096921A1,CC(C)c1onc(-c2c(Cl)cccc2Cl)c1CO>>CC(C)c1onc(-c2c(Cl)cccc2Cl)c1C=O,,ClCCl,,,,val
US04182773,CC(=O)OCCCCCC1C(=O)CCC1C#N>>N#CC1CCC(=O)C1CCCCCO,,CO,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US04939161,CCOC(=O)CCN(Cc1ccccc1)CC(C)C(=O)OC>>COC(=O)C1CN(Cc2ccccc2)CC(C)C1=O,,Cc1ccccc1,,[H-].[Na+],,val
US05185360,NNc1ccccc1.O=C1Cc2ccccc2C1>>c1ccc2[nH]ccc2c1,,CC(=O)O,,Cl,,val
US20150191461A1,CI.OC1COC(c2ccccc2)OC1>>COC1COC(c2ccccc2)OC1,,C1CCOC1,O,[H-].[Na+],,val
US20090136473A1,COC(=O)Cl.COc1ccc(CO)c(F)c1-c1cccc(Cl)c1>>COC(=O)OCc1ccc(OC)c(-c2cccc(Cl)c2)c1F,,C1CCOC1,,c1ccncc1,,val
US05674909,CCCCOC(=O)N(CCC)C1CCc2c(ccc(OCc3ccccc3)c2OCc2ccccc2)C1.Cl>>CCCN[C@H]1CCc2c(ccc(OCc3ccccc3)c2OCc2ccccc2)C1.Cl,,CCOC(C)=O,,,,val
US20100041760A1,CC(C)(C)OC(=O)COc1cccc2c1CCC[C@H]2N.O=S(=O)(Cl)c1cc(F)cc(C(F)(F)F)c1>>CC(C)(C)OC(=O)COc1cccc2c1CCC[C@H]2NS(=O)(=O)c1cc(F)cc(C(F)(F)F)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US04518596,CSc1ncnc2c(N3CCOCC3)nc(N3CCN(C=O)CC3)nc12>>CSc1ncnc2c(N3CCOCC3)nc(N3CCNCC3)nc12,,CCO,,Cl,,val
US05705499,BrCc1ccccc1.CCN1c2ncc(O)cc2C(=O)N(C)c2ccc(Cl)nc21>>CCN1c2ncc(OCc3ccccc3)cc2C(=O)N(C)c2ccc(Cl)nc21,,C1CCOC1,,[H-].[Na+],,val
US06218376B1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1nc2c(o1)C=Cc1ccccc1C2c1cn(C)c(=O)[nH]c1=O>>Cc1nc2c(o1)C=Cc1ccccc1C2c1cn(C)c(=O)[nH]c1=S,,C1COCCO1,,,,val
US20050187297A1,CCC(=O)Cl.COC(=O)c1cc(Br)ccc1N>>CCC(=O)Nc1ccc(Br)cc1C(=O)OC,,ClC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20110081363A1,CCOC(=O)CBr.CN1CCOCC1>>CCOC(=O)C[N+]1(C)CCOCC1.[Br-],,ClCCl,,,,val
US20080004302A1,Cc1cc(CN)on1.Clc1nccc(Nc2cc(COc3ccccc3)n[nH]2)n1>>Cc1cc(CNc2nccc(Nc3cc(COc4ccccc4)n[nH]3)n2)on1,,COCCO,,CCN(C(C)C)C(C)C,,val
US20100197715A1,CC(C)=O.COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)NC1(c2ccccc2)CCCNC1>>COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)NC1(c2ccccc2)CCCN(C(C)C)C1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20150274691A1,CC(C)(C)C(=O)Cl.Cc1cc(C)c(-c2c(O)cc(CCOCc3ccccc3)oc2=O)c(C)c1>>Cc1cc(C)c(-c2c(OC(=O)C(C)(C)C)cc(CCO)oc2=O)c(C)c1,,c1ccncc1,,O,,val
US20100317582A1,CCOC(=O)c1ccc(C2CCCC(N[C@H](C)c3cccc4ccccc34)C2)o1>>C[C@@H](NC1CCCC(c2ccc(C(=O)O)o2)C1)c1cccc2ccccc12,,CO,O,[Li+].[OH-],,val
US20160016908A1,CC(=O)N1c2ccc(N3CCOCC3)nc2[C@H](NC(=O)OCc2ccccc2)[C@@H](C)[C@@H]1C1CC1>>CC(=O)N1c2ccc(N3CCOCC3)nc2[C@H](N)[C@@H](C)[C@@H]1C1CC1,[Pd],CO,,,,val
US20060084645A1,CC(=O)c1cccc(B(O)O)c1.FC(F)(F)Oc1ccc(Nc2cc(Cl)nc(N3CCOCC3)n2)cc1>>CC(=O)c1cccc(-c2cc(Nc3ccc(OC(F)(F)F)cc3)nc(N3CCOCC3)n2)c1,,CN(C)C=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US20130331375A1,Clc1nc(Cl)c2ccn(C3CC3)c2n1.[OH-]>>O=c1[nH]c(Cl)nc2c1ccn2C1CC1,,O,,Cl,,val
US20160096839A1,C[C@@H]1CCC[C@H](NC(=O)OC(C)(C)C)c2cccc(n2)-c2c(cnn2C)NC1=O>>C[C@@H]1CCC[C@H](N)c2cccc(n2)-c2c(cnn2C)NC1=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US05155268,CCCCCCCN(CC)CCc1ccc(N)cc1.CS(=O)(=O)Cl>>CCCCCCCN(CC)CCc1ccc(NS(C)(=O)=O)cc1,,c1ccncc1,,,,val
US20130150343A1,C[C@H]1COCCN1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.c1ccncc1>>C[C@H]1COCCN1.NC(=O)Cl,,ClCCl,,,,val
US20090176760A1,CCO.CCOC(OCC)(OCC)OCC.Nc1c(Cl)cccc1[N+](=O)[O-]>>CCOc1nc2cccc(Cl)c2[nH]1,,CCO,,[Na+].[OH-],,val
US04567271,CC(=O)CC(=O)OCC(C)C.COC(=O)/C=C(/C)N.O=Cc1cccc2nonc12>>COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1cccc2nonc12,,CCO,,,,val
US20100105921A1,CCOC(=O)/C=C/C=O.O=Nc1ccccc1>>CCOC(=O)/C=C/C(=O)N(O)c1ccccc1,,ClCCl,,C1CCC2=NCCCN2CC1,,val
US20110092423A1,CCOC(=O)c1cnc(-c2ccnn2C)o1.O=C1CCC(=O)N1Cl>>Cn1ncc(Cl)c1-c1ncc(C(=O)O)o1,,CN(C)C=O,,[Na+].[OH-],,val
US04059433,CCOC(N)=C(C#N)C#N.S>>CCOC(N)=C(C#N)C(N)=S,,c1ccncc1,,CCN(CC)CC,,val
US04637902,CN(C)C(=O)Cl.CN(C)C=O.O=C(NO)c1cc(Br)ccc1O>>CN(C)C(=O)O.O=C(NO)c1cc(Br)ccc1O,,CN(C)C=O,,CCN(CC)CC,,val
US20150259343A1,CC(C)(C)OC(=O)N1CCN2CCC(C3CC3)c3cc(C#N)cc(c32)C1>>N#Cc1cc2c3c(c1)C(C1CC1)CCN3CCNC2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150329653A1,CC(Cc1ccc(C(C)C)cc1)C(=O)Cl>>CC1Cc2ccc(C(C)C)cc2C1=O,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080207654A1,CCCc1nc(CC)n(-c2ccc(OC3CCC[C@H]3O)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCc1nc(CC)n(-c2ccc(OC3CCC[C@H]3O)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,O,,CS(C)=O,[Cl-].[Na+],val
US20130140549A1,CC1(C)OB(c2ccc3c(c2)c2ccccc2n3-c2ccccc2)OC1(C)C.Ic1ccc2[nH]c3ccccc3c2c1>>c1ccc(-n2c3ccccc3c3cc(-c4ccc5[nH]c6ccccc6c5c4)ccc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US04689327,CNC(=O)N1CCSC1c1ccccc1OCCCl.c1ccc(N2CCNCC2)cc1>>CNC(=O)N1CCSC1c1ccccc1OCCN1CCN(c2ccccc2)CC1,,CN(C)C=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20160159808A1,CCOC(=O)CC(=O)C1CC1.CCOC(=O)c1c[nH]nc1N>>CCOC(=O)c1cnn2c(O)cc(C3CC3)nc12,,CC(=O)O,CCO,,,val
US03997536,CCCCc1ccc(-c2ncc(C#N)c(Cl)n2)cc1>>CCCCc1ccc(-c2ncc(C#N)cn2)cc1,[Zn],C1COCCO1,,,,val
US20130040931A1,CI.Cc1cccc(C(=O)NCC(C)(C)C)c1Br>>Cc1cccc(C(=O)N(C)CC(C)(C)C)c1Br,,C1CCOC1,,[H-].[Na+],,val
US04390618,CCOC(=O)COc1cc(C(=O)O)c(O)c2ccccc12.O=[N+]([O-])c1ccc(O)cc1>>CCOC(=O)COc1cc(C(=O)Oc2ccc([N+](=O)[O-])cc2)c(O)c2ccccc12,,Cc1ccccc1,,O=S(Cl)Cl,,val
US20110021491A1,CC(C)(C)OC(=O)N1CCC(O)CC1.CS(=O)(=O)c1ccc2c(c1)CCN2c1ncnc(Cl)n1>>CC(C)(C)OC(=O)N1CCC(Oc2ncnc(N3CCc4cc(S(C)(=O)=O)ccc43)n2)CC1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US06498254B1,SCc1ccccc1.[O-][n+]1cc(Cl)ccc1Cl>>[O-][n+]1cc(Cl)ccc1SCc1ccccc1,,CCO,,O,[K+].[OH-],val
US20140350019A1,CCOC(=O)COc1ccc(C)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1C>>Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)ccc1F,,C1CCOC1,,[Na+].[OH-],,val
US20090042949A1,CCOC(=O)c1cc2cc(O)ccc2n1-c1ccc(OC(C)C)cc1.FC(F)(F)c1ccc(Cl)nc1>>CCOC(=O)c1cc2cc(Oc3ccc(C(F)(F)F)cn3)ccc2n1-c1ccc(OC(C)C)cc1,C1COCCOCCOCCOCCOCCO1,ClCCl,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050239814A1,CCOC(=O)CC(=O)OCC.COC(=O)c1c(Cl)ccc([N+](=O)[O-])c1N>>CCOC(=O)C(C(=O)OCC)c1ccc([N+](=O)[O-])c(N)c1C(=O)OC,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20130317023A1,Nc1ccc(F)c(Nc2ncccc2-c2ncnc3c2ncn3C2CCCCO2)c1F.O=S(=O)(Cl)c1ccc(F)c(Cl)c1>>O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3c2ncn3C2CCCCO2)c1F)c1ccc(F)c(Cl)c1,,ClCCl,,c1ccncc1,,val
US20150148349A1,CC(C)(C)[Si](C)(C)Cl.CCOC(=O)C1CCCC(O)C1>>CCOC(=O)C1CCCC(O[Si](C)(C)C(C)(C)C)C1,,CC#N,,c1c[nH]cn1,,val
US20120245143A1,CC1c2cccc(C(N)=O)c2C(=O)N1C1CCN(C(=O)OC(C)(C)C)CC1>>CC1c2cccc(C(N)=O)c2C(=O)N1C1CCNCC1,,Cl,,C1COCCO1,,val
US05024994,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C(N)C(=O)OCc1ccccc1>>COC(=O)C(N)(C(=O)OCc1ccccc1)C(=O)OC(C)(C)C,,CCOCC,,,,val
US20100249075A1,COc1ccc(C2C(O)c3ccc(OC)c([N+](=O)[O-])c3C3CCCCC32)cc1>>COc1ccc(C2=Cc3ccc(OC)c([N+](=O)[O-])c3C3CCCCC23)cc1,,CCOC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,val
US05001275,CC(C)CCO.O=[N+]([O-])c1cccc(CCl)c1>>CC(C)CCOCc1cccc([N+](=O)[O-])c1,,CN(C)C=O,,[K+].[OH-],,val
US20130317057A1,CC(C)(C)[Si](C)(C)OCCNc1cc(F)c(F)cc1[N+](=O)[O-]>>CC(C)(C)[Si](C)(C)OCCNc1cc(F)c(F)cc1N,[Pd],CO,,[H][H],,val
US20070179196A1,COc1c2c(c(Br)[nH]c1=O)CCN(Cc1ccc(F)c(Cl)c1)C2=O>>O=C1c2c(c(Br)[nH]c(=O)c2O)CCN1Cc1ccc(F)c(Cl)c1,,Br,CC(=O)O,,,val
US20100286169A1,CCCSCc1csc(NC(=O)OC(C)(C)C)n1.O=S([O-])OO>>CCCS(=O)(=O)Cc1csc(NC(=O)OC(C)(C)C)n1,,CO,,O,,val
US05859051,CCCc1c(OCc2ccccc2)ccc2c(C(C)(C)C)cc(=O)oc12.CCOC(C)=O>>CCCc1c(O)ccc2c(C(C)(C)C)c(C)c(=O)oc12,[Pd],,,,,val
US20100130492A1,Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2nc(Cl)n(CC3CC3)c2n1.NC(=O)C1CCNCC1>>Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2nc(N3CCC(C(N)=O)CC3)n(CC3CC3)c2n1,,O,,CN1CCCC1=O,,val
US06313160B1,CCCC(=O)Cl.COc1ccc2c(c1)C=C(CN)CO2>>CCCC(=O)NCC1=Cc2cc(OC)ccc2OC1,,ClCCl,,CCN(CC)CC,Cl,val
US20060235033A1,COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.C[C@@H](N)c1cccc(Br)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3cc(C)c(NC(=O)N[C@H](C)c4cccc(Br)c4)cc3C)c2cc1OC,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20040138300A1,CCOC(Cc1ccc(OCCc2ccc(N)cc2)cc1)C(=O)O.CN=C(Nc1ccccc1)SC>>CCOC(Cc1ccc(OCCc2ccc(NC(=NC)Nc3ccccc3)cc2)cc1)C(=O)O,Cl[Hg]Cl,CN(C)C=O,,CCN(CC)CC,,val
US20080153852A1,CC#N.N[C@@H](Cc1ccc(B(O)O)cc1)C(=O)O.Nc1nc(Cl)cc(OC(c2ccc(-c3ccncc3)cc2)C(F)(F)F)n1>>Nc1nc(OC(c2ccc(-c3ccncn3)cc2)C(F)(F)F)cc(-c2ccc(C[C@H](N)C(=O)O)cc2)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,O=C([O-])[O-].[Na+].[Na+],,val
US04006145,Cc1ccc(Sc2ccccc2)c(CO)c1.O=S(Cl)Cl>>Cc1ccc(Sc2ccccc2)c(CCl)c1,,c1ccccc1,,,,val
US20110201604A1,CCn1c(Nc2nc3ccc(C(F)(F)F)cc3s2)nc2cc(C(=O)O)ccc21.CN(C)C(=O)CN>>CCn1c(Nc2nc3ccc(C(F)(F)F)cc3s2)nc2cc(C(=O)NCC(=O)N(C)C)ccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20110003848A1,CC(C)(C)c1cc(N)[nH]n1.CC(C)[Si](Oc1ccc(I)cc1Cl)(C(C)C)C(C)C>>CC(C)[Si](Oc1ccc(-n2nc(C(C)(C)C)cc2N)cc1Cl)(C(C)C)C(C)C,[Cu]I,Cc1ccccc1,,CN[C@@H]1CCCC[C@H]1NC,O=C([O-])[O-].[K+].[K+],val
US05189054,CCOC(=O)c1c(NCCC(=O)c2ccccc2)c2cc(Cl)c(Cl)cc2n1C(=O)OC(C)(C)C>>CCOC(=O)c1[nH]c2cc(Cl)c(Cl)cc2c1NCCC(=O)c1ccccc1,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,,val
US20160016968A1,CC(C)(C)OC(=O)N1CCC[C@H]1COc1cc(-c2nc(C(C)(C)C)no2)ncc1C1CC1>>CC(C)(C)c1noc(-c2cc(OC[C@@H]3CCCN3)c(C3CC3)cn2)n1,,Cl,,C1COCCO1,,val
US20040132727A1,CC(O)c1cccc(C(F)(F)F)c1.COc1cc2ncnc(Oc3ccc(N)c(Cl)c3)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)OC(C)c4cccc(C(F)(F)F)c4)c(Cl)c3)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US20160052920A1,CC(C)(C)OC(=O)N(C(=O)c1ccccc1)C1=N[C@](C)(c2nc(Br)ccc2F)[C@@H](F)[C@@H](C(F)(F)F)O1>>CC(C)(C)OC(=O)NC1=N[C@](C)(c2nc(Br)ccc2F)[C@@H](F)[C@H](C(F)(F)F)O1,,CO,,N,,val
US20140024646A1,CNC(=O)N1C[C@@H]2C[C@@H](NC(=O)OC(C)(C)C)C[C@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1>>CNC(=O)N1C[C@@H]2C[C@@H](N)C[C@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080032970A1,CN1C(=O)N(c2cc(NC(=O)c3ccc(-c4ccccc4)cc3)ccc2Cl)Cc2cnc(S(C)(=O)=O)nc21.N>>CN1C(=O)N(c2cc(NC(=O)c3ccc(-c4ccccc4)cc3)ccc2Cl)Cc2cnc(N)nc21,,C1CCOC1,,,,val
US20150299186A1,Cc1c(Nc2cccc(N3CC(O)C3)c2)c2c(=O)n(C3CC3)c(=O)n(-c3ccc(I)cc3F)c2n(C)c1=O>>Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(N4CC(O)C4)c3)c12,,C1CCOC1,,C[O-].[Na+],,val
US20130123234A1,BrC(Br)(Br)Br.CCN(c1cc(-c2ccc(CO)nc2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1>>CCN(c1cc(-c2ccc(CBr)nc2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1,,ClCCl,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US05166398,COC(=O)C(C)(C)CCCBr.COc1cc(C)c(O)cc1C>>COC(=O)C(C)(C)CCCOc1cc(C)c(OC)cc1C,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100261728A1,N#Cc1ccc(N)cn1.O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1>>N#Cc1ccc(NC(=O)N2CCc3ccccc3[C@H]2c2ccc(C(F)(F)F)cc2)cn1,,C1CCOC1,,O,[H-].[Na+],val
US20080076745A1,CC(C)(C)OC(=O)N[C@H](CO)CCNC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N[C@H](CO)CCN,[Pd],CCO,,,,val
US20140288094A1,CCOC(=O)CCn1nc(-c2cccnc2)c(C#N)c1N>>N#Cc1c(-c2cccnc2)nn2c1NC(=O)CC2,,C1CCOC1,,O,[Li]CCCC,val
US05571813,CCc1cc(Cl)n2nccc2n1.N#Cc1ccccc1-c1oc2ccc(CN)cc2c1Br>>CCc1cc(NCc2ccc3oc(-c4ccccc4C#N)c(Br)c3c2)n2nccc2n1,,CCO,,CCN(CC)CC,,val
US05834494,c1cc2cc(-c3ccsc3)ccc2[nH]1>>c1cc(-c2ccc3c(c2)CCN3)cs1,,CC(=O)O,,[BH3-]C#N.[Na+],,val
US03974283,C=CCN=C=S.CC(C)(C)C1=CCNCC1>>C=CCNC(=S)N1CC=C(C(C)(C)C)CC1,,C1CCOC1,,,,val
US20050032650A1,CC(C)CN(C=NS(=O)(=O)c1c(Cl)nc2ccc(C3CC3)nn12)CC(C)C>>NS(=O)(=O)c1c(Cl)nc2ccc(C3CC3)nn12,,C1COCCO1,,Cl,,val
US20140296208A1,C#Cc1cc(Nc2cc(Oc3ccc(N)c4ccccc34)ccn2)cc(C(=O)N[C@@H](C)COCCOCCOC)c1.COc1c(NC(=O)Oc2ccccc2)cc(C(C)(C)C)cc1NS(C)(=O)=O>>C#Cc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(NS(C)(=O)=O)c4OC)c4ccccc34)ccn2)cc(C(=O)N[C@@H](C)COCCOCCOC)c1,,CC(=O)OC(C)C,,CCN(CC)CC,,val
US20110178041A1,COc1cccc2cncnc12.O=C1CCC(=O)N1Br>>COc1ccc(Br)c2cncnc12,,CN(C)C=O,,O=C([O-])O.[Na+],,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCCO)cc1CC2CC>>CCC1Cc2cc(OCCCO)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21,,C1CCOC1,,Cl,[Na+].[OH-],val
US20120077828A1,CC1(C)OB(c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)c2)OC1(C)C.Nc1ncnc2c1c(Br)cn2C1COC1>>Nc1ncnc2c1c(-c1ccc3c(c1)CCN3C(=O)Cc1cccc(C(F)(F)F)c1)cn2C1COC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])O.[Na+],val
US20090209693A1,COC(=O)CC(=O)C(C)C>>CC(C)C(=O)CC(=O)O,,O,,[Na+].[OH-],,val
US20110288067A1,CC(C)(C)OC(=O)N[C@@H](CO)C(C)(C)C.CI>>COC[C@H](NC(=O)OC(C)(C)C)C(C)(C)C,O=[Ag],CC#N,,,,val
US20060135578A1,CCOP(=O)(CP(=O)(OCC)OCC)OCC.COc1cc(COc2nn(-c3ccccc3)cc2C=O)ccc1OCc1sc(-c2ccccc2)nc1C>>CCOP(=O)(/C=C/c1cn(-c2ccccc2)nc1OCc1ccc(OCc2sc(-c3ccccc3)nc2C)c(OC)c1)OCC,,O,,CN(C)C=O,[H-].[Na+],val
US20030220368A1,COc1ncccc1CN1CCCCC1CC(=O)O.NCc1ccccc1>>COc1ncccc1CN1CCCCC1CC(=O)NCc1ccccc1,,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US05389614,CC(=O)N([C@@H](CC(=O)O)C(=O)N[C@H](C(=O)O)C(C)C)N1C(=O)C(=Cc2ccc(C#N)cc2)N(C)C1=O>>CC(=O)N([C@@H](CC(=O)O)C(=O)N[C@H](C(=O)O)C(C)C)N1C(=O)C(Cc2ccc(CN)cc2)N(C)C1=O,,CO,,,,val
US20060069110A1,CSc1nccc(N(C)c2cc(-c3ccccc3)cnn2)n1.O=C(OO)c1cccc(Cl)c1>>CN(c1cc(-c2ccccc2)cnn1)c1ccnc(S(C)=O)n1,,ClCCl,,,,val
US06242443B1,Br.CC(C)NC1=NS(=O)(=O)c2ccc(C(F)(F)F)cc2N1>>CC(C)NC1=NS(=O)(=O)c2cc(Br)c(C(F)(F)F)cc2N1,,O,,OO,,val
US20040116467A1,CN(C)N.N#Cc1ccc(CC2CCCCC2=O)cc1>>CN(C)N=C1CCCCC1Cc1ccc(C#N)cc1,,CCO,,,,val
US20070037888A1,CC(C)(C)ON1CCCC1C#N.[N-]=[N+]=[N-].[NH4+]>>CC(C)(C)ON1CCCC1c1nn[nH]n1,,CN(C)C=O,,[Cl-].[Na+],,val
US20070032485A1,CCCOC(=O)Cl.CCOC(=O)C1CCN(c2cnc(N[C@H]3C[C@@H](CC)Nc4ccc(OC)nc43)nc2Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1>>CCCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(N3CCC(C(=O)O)CC3)c(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)C[C@H]1CC,,ClCCl,,c1ccncc1,O=C([O-])O.[Na+],val
US20030073710A1,ClCc1nc2ccccc2[nH]1.Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1>>O=S(=O)(Nc1ncccn1)c1ccc(NCc2nc3ccccc3[nH]2)cc1,,[Na+],[OH-],CC(=O)O,,val
US20130261128A1,C[Si](C)(C)CCOCCl.FC(F)(F)c1cnc(-c2ncc(Br)cc2Cl)[nH]1>>C[Si](C)(C)CCOCn1cc(C(F)(F)F)nc1-c1ncc(Br)cc1Cl,,CN(C)C=O,,O,[H-].[Na+],val
US20070208056A1,CC(C)[C@@H](NC(N)=S)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1.O=C(CCl)CCl>>CC(C)[C@@H](Nc1nc(CCl)cs1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1,,CC(C)=O,,,,val
US05571845,COC(=O)c1cc([N+](=O)[O-])c(Cl)c([N+](=O)[O-])c1.OCCNCCO>>COC(=O)c1cc([N+](=O)[O-])c(N(CCO)CCO)c([N+](=O)[O-])c1,,C1COCCO1,,,,val
US20100105744A1,CCO.CSCc1c(F)ccc2c(C(c3ccc(Cl)cc3)C3C(=O)OC(C)(C)OC3=O)c[nH]c12>>CCOC(=O)CC(c1ccc(Cl)cc1)c1c[nH]c2c(CSC)c(F)ccc12,[Cu],CCO,c1ccncc1,,,val
US20160039834A1,Cc1noc(C)c1-c1nc(-c2cc(OC[C@@H](CN(C)C(=O)OC(C)(C)C)O[Si](C)(C)C(C)(C)C)ccc2Cl)nc(N2Cc3cnn(C4CC4)c3C2)c1C>>CNC[C@@H](O)COc1ccc(Cl)c(-c2nc(-c3c(C)noc3C)c(C)c(N3Cc4cnn(C5CC5)c4C3)n2)c1.O=CO,,C1COCCO1,Cl,,,val
US20110257198A1,Cc1ccc(OCC2CC2)c(C(=O)N2CCCC[C@H]2Cc2nc3c(C)cccn3c2Cl)n1.Cl>>Cc1ccc(OCC2CC2)c(C(=O)N2CCCC[C@H]2Cc2nc3c(C)cccn3c2Cl)n1.Cl,,ClCCl,,,,val
US20140080800A1,CC(C)(C)OC(=O)NCC1CN(C(=O)Nc2cc(-c3ccc(F)cc3)ccc2[N+](=O)[O-])C1>>NCC1CN(C(=O)Nc2cc(-c3ccc(F)cc3)ccc2[N+](=O)[O-])C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140094495A1,CNCC(C)(CO)[N+](=O)[O-].Cl>>CNCC(C)(N)CO.Cl,[Ni],CO,O,,,val
US20060194801A1,CC(C)(C)OC(=O)c1ccc(Br)cc1F.CN(C)C=O>>CC(C)(C)OC(=O)c1ccc(C=O)cc1F,,C1CCOC1,,[Li]CCCC,,val
US20150119586A1,BrCCC1OCCO1.CS(=O)(=O)c1ccc(Br)c(Cl)c1O>>CS(=O)(=O)c1ccc(Br)c(Cl)c1OCCC1OCCO1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20100130738A1,C1CCOC1.CC(C)(C)[Si](C)(C)OCc1ccc(I)n2nc(C(F)(F)F)nc12>>COc1ccc(C=O)c2nc(C(F)(F)F)nn12,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US05977376,COC(=O)c1ccc(F)cc1C(F)(F)F.c1nc[nH]n1>>COC(=O)c1ccc(-n2cncn2)cc1C(F)(F)F,,CN(C)C=O,,CCOCC,O=C([O-])[O-].[K+].[K+],val
US05929103,CC1Cc2ccccc2N1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC1Cc2ccccc2N1C(=O)C(F)(F)F,,ClCCl,,c1ccncc1,,val
US20150025068A1,COCC(C)O.O=C(O)c1ccc(NS(=O)(=O)c2cccc(-c3cc(F)ccc3O)c2)cc1O>>COCC(C)OC(=O)c1ccc(NS(=O)(=O)c2cccc(-c3cc(F)ccc3O)c2)cc1O,,CC#N,,O=S(=O)(O)O,,val
US20130344385A1,C=O.N=C(N)NC(N)=S>>C=O.N=C(N)NC(N)=S,,O,,,,val
US20150141471A1,CCOC(=O)C(C)(C)OCc1cc(-c2ccc(Cl)cc2Cl)c(-c2ccc(C(F)(F)F)cc2)nc1C>>Cc1nc(-c2ccc(C(F)(F)F)cc2)c(-c2ccc(Cl)cc2Cl)cc1COC(C)(C)C(=O)O,,C1CCOC1,O,Cl,[Li+].[OH-],val
US20140162985A1,C=CC(C)=O.CCC1C(=O)CCCc2cc3c(cnn3-c3ccc(F)cc3)cc21>>CCC12CCC(=O)C=C1CCCc1cc3c(cnn3-c3ccc(F)cc3)cc12,,CCO,,[Na],,val
US05998412,C[Si](C)(C)CCS(=O)(=O)n1cc(C2CCN(S(=O)(=O)N3CCN(C(=O)OCc4ccccc4)CC3C(=O)NO)CC2)c2cc(F)ccc21>>O=C(NO)C1CN(C(=O)OCc2ccccc2)CCN1S(=O)(=O)N1CCC(c2c[nH]c3ccc(F)cc23)CC1,,C1CCOC1,,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20120202785A1,O=C1CCC(=O)N1Br.OCc1nc2ccccc2n1-c1ccccc1>>BrCc1nc2ccccc2n1-c1ccccc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US04376771,Nc1ccc(C2=NNC(=O)CC2)cc1.O=C(Cl)CCl>>O=C1CCC(c2ccc(NC(=O)CCl)cc2)=NN1,,c1ccccc1,,,,val
US20150210647A1,COC(=O)c1ccc2cnc(N[C@@H]3CC[C@@H](C(C)(C)C)CC3)cc2c1.O=C1CCC(=O)N1Cl>>COC(=O)c1ccc2cnc(N[C@@H]3CC[C@@H](C(C)(C)C)CC3)c(Cl)c2c1,,ClCCl,,,,val
US20070203136A1,Clc1ccc(-c2nccs2)nn1.NNC(=O)Cc1ccc(O)cc1>>Oc1ccc(Cc2nnc3ccc(-c4nccs4)nn23)cc1,,CCCCO,,,,val
US05334600,Fc1ccc(-c2ccc(CCl)nc2)cc1.O=C1NCCc2cc(Br)ccc21>>O=C1c2ccc(Br)cc2CCN1Cc1ccc(-c2ccc(F)cc2)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20050215605A1,CC(C)(C)OCCC(=O)O.N/C(=N\O)[C@H](NC(=O)C1SCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1)c1ccccc1>>CC(C)(C)OCCC(=O)N/C(=N/O)C(NC(=O)C1SCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1)c1ccccc1,,C1CCOC1,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US05241064,C=C(C(=O)OC)C(C)OC(C)=O>>C=C(C(=O)OC)[C@@H](C)O,,O=P([O-])([O-])[O-],,,,val
US20090270351A1,C=CP(=O)(C=C)c1ccccc1.NCc1ccccc1>>O=P1(c2ccccc2)CCN(Cc2ccccc2)CC1,,O,,,,val
US20090275606A1,C=CCC1(S(=O)(=O)Cl)CC1.O=c1c(F)c2c([nH]c(=O)n2-c2ccc(Br)cc2F)c2n1CCC2>>C=CCC1(S(=O)(=O)n2c(=O)n(-c3ccc(Br)cc3F)c3c(F)c(=O)n4c(c32)CCC4)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20150051171A1,Cc1ccc(-n2ccc(O)n2)cc1.Cn1nnn(-c2cccc(Cl)c2CBr)c1=O>>Cc1ccc(-n2ccc(OCc3c(Cl)cccc3-n3nnn(C)c3=O)n2)cc1,,O,,CC#N,O=C([O-])[O-].[K+].[K+],val
US06350749B1,COC(CC(C)=O)OC.NC1=CC(=O)CC(c2ccccc2Cl)C1>>Cc1ccnc2c1C(=O)CC(c1ccccc1Cl)C2,,CCO,Cc1ccccc1,[K+].[OH-],,val
US20140329798A1,CCc1cnc(N2CCC([C@H]3C[C@H]3CCO)CC2)nc1.O=C(Cc1ccc(Cl)nc1)N1CCC1>>CCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)cn3)CC2)nc1,,CC#N,CN(C)C=O,CC(C)(C)[O-].[K+],,val
US05081246,COc1ccc(N)cc1OC.O=S(=O)(Cl)c1cccc2cnccc12>>COc1ccc(NS(=O)(=O)c2cccc3cnccc23)cc1OC,,c1ccncc1,,Cl,,val
US20070249642A1,Cl.O=c1[nH]c(=O)n(CCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)cc1C(F)(F)F>>Cl.O=c1[nH]c(=O)n(CCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)cc1C(F)(F)F,,C1COCCO1,,,,val
US20150353553A1,COC(=O)[C@@H]1CC[C@@H](CF)CC1>>OC[C@@H]1CC[C@@H](CF)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20090186918A1,CCOC(=O)c1cnc2ccc(F)cc2c1Cl>>CCOC(=O)c1cnc2ccc(F)cc2c1,[Pd],CC(=O)O,,,,val
US20150175604A1,CC(=O)Cl.Cc1nnc2ccc3c(cc(-c4ccn(C5CNC5)n4)n3Cc3cccc(Cl)c3)n12>>CC(=O)N1CC(n2ccc(-c3cc4c(ccc5nnc(C)n54)n3Cc3cccc(Cl)c3)n2)C1,,ClCCl,,CCN(CC)CC,,val
US20160016907A1,COC(=O)c1cc(Cc2ccc(-n3cccn3)cc2)c(Cl)cn1>>O=C(O)c1cc(Cc2ccc(-n3cccn3)cc2)c(Cl)cn1,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20080111107A1,C=C[C@@H]1CC[C@@H]([C@@H]2CC[C@@H](COS(C)(=O)=O)CC2)CC1.CCOc1ccc(O)c(F)c1F>>C=C[C@@H]1CC[C@@H]([C@@H]2CC[C@@H](COc3ccc(OCC)c(F)c3F)CC2)CC1,,CN(C)C=O,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20130116443A1,COCc1cc([N+](=O)[O-])ccc1-n1cccc(CC(=O)O)c1=O>>COCc1cc([N+](=O)[O-])ccc1-n1cccc(CCO)c1=O,,C1CCOC1,CCOC(C)=O,Cl,,val
US20150080393A1,CC(=O)c1ccc(Cl)cc1-n1ccc(C)n1>>Cc1ccn(-c2cc(Cl)ccc2C(C)O)n1,,CO,,[BH4-].[Na+],,val
US20050031576A1,CCOC(=O)C(C)(OCC)OCC>>CCOC(C)(CO)OCC,,CCOCC,,[H-].[Na+],,val
US20130116246A1,Cc1cc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3C=O)cn(C)c2=O)no1>>Cc1cc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cn(C)c2=O)no1,,CO,,[BH4-].[Na+],,val
US20100105667A1,CC(C)(C)OC(=O)Nc1ccc(CN2CCNCC2(C)C)cn1.CI>>CN1CCN(Cc2ccc(NC(=O)OC(C)(C)C)nc2)C(C)(C)C1,,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US04105790,COC(=O)CBr.O=C(OCc1ccccc1)c1ccc(O)cc1>>COC(=O)COc1ccc(C(=O)OCc2ccccc2)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05616599,CCCCc1nc(C(=O)c2ccccc2)c(C#N)n1C(c1ccccc1)(c1ccccc1)c1ccccc1>>CCCCc1nc(C(=O)c2ccccc2)c(C#N)[nH]1,,CC(=O)O,,,,val
US20040038858A1,C[C@@H](N)C(=O)O.O=C=Nc1ccc(Cl)cc1>>C[C@@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)O,,O,,O=C([O-])O.[Na+],,val
US05994378,CCOC(=O)C(Cc1ccc2c(c1)c(C#N)cn2Cc1ccc2oc(-c3nc(C(C)(C)C)cs3)cc2c1)C(=O)OCC>>CC(C)(C)c1csc(-c2cc3cc(Cn4cc(C#N)c5cc(CCC(=O)O)ccc54)ccc3o2)n1,,CO,,Cl,[Na+].[OH-],val
US04929741,COC(=O)C#CC(=O)c1ccc(OC)c(OC)c1OC>>COc1ccc(C(=O)C#CC(=O)O)c(OC)c1OC,,C1CCOC1,,O,[K+].[OH-],val
US20110201604A1,CN(C)C(=O)CN.CN(CCn1c(Nc2nc3ccc(Cl)cc3s2)nc2cc(C(=O)O)ccc21)C(=O)OC(C)(C)C>>CN(C)C(=O)CNC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(Cl)cc3s1)n2CCN(C)C(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20040254183A1,CC(=O)Cl.Cc1sc(N)nc1-c1c2c(=O)n(C)c(=O)n(CC(C)C)c2nn1Cc1csc2ccccc12>>CC(=O)Nc1nc(-c2c3c(=O)n(C)c(=O)n(CC(C)C)c3nn2Cc2csc3ccccc23)c(C)s1,,CCN(CC)CC,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090221555A1,CC1(C)NC(=O)CCc2cc(N)ccc21.CNC(=O)c1cccc(C)c1Nc1nc(Cl)ncc1Cl>>C=C(C)c1ccc(Nc2ncc(Cl)c(Nc3c(C)cccc3C(=O)NC)n2)cc1CCC(N)=O,,CC(C)O,,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US20080021126A1,CCC(Cc1ccc([N+](=O)[O-])cc1)(C(=O)c1ccc(F)cc1)N(C)C>>CCC(Cc1ccc(N)cc1)(C(=O)c1ccc(F)cc1)N(C)C,[Pd],CCO,,[H][H],,val
US20090324569A1,COc1ccc(CBr)cc1Br.c1ccc2[nH]ccc2c1>>COc1ccc(Cn2ccc3ccccc32)cc1Br,,CN(C)C=O,ClCCl,[H-].[Na+],[Cl-].[NH4+],val
US04450169,COC(=O)/C=C/[C@H]1[C@@H](C(=O)O)C1(C)C.OCc1cnc(Oc2ccccc2)s1>>COC(=O)/C=C/[C@H]1[C@@H](C(=O)OCc2cnc(Oc3ccccc3)s2)C1(C)C,CN(C)c1ccncc1,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060281757A1,CC(C)(C)OC(=O)N1CCNCC1.O=S(=O)(c1ccccc1)c1cccc(Br)c1>>CC(C)(C)OC(=O)N1CCN(c2cccc(S(=O)(=O)c3ccccc3)c2)CC1,,C1COCCO1,,c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1,O=C([O-])[O-].[Cs+].[Cs+],val
US04908363,CI.Sc1nccn1N=Cc1ccccc1>>CSc1nccn1N=Cc1ccccc1,,CCO,,[Na],,val
US20110230486A1,Cc1cc(OC(C)C)cc(C)c1C(=O)CBr.NC(N)=S>>Cc1cc(OC(C)C)cc(C)c1-c1csc(N)n1,,CCO,,,,val
US20090156571A1,COC(=O)c1ccc(B(O)O)cc1.CO[C@@H]1CC[C@@H](N2CC[C@@H](Cc3c(Cl)cc(OS(=O)(=O)C(F)(F)F)cc3Cl)C2=O)CC1>>COC(=O)c1ccc(-c2cc(Cl)c(C[C@@H]3CCN([C@@H]4CC[C@@H](OC)CC4)C3=O)c(Cl)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US20150119405A1,C[C@@H](N)c1ccccc1.C[C@H]1CC2OC2CO1>>C[C@H]1C[C@H](N[C@@H](C)c2ccccc2)[C@@H](O)CO1,,CC(C)O,,,,val
US20120245137A1,COC(=O)C1CC(OS(C)(=O)=O)C1.FC(F)(F)c1cccc(S)c1>>COC(=O)C1CC(Sc2cccc(C(F)(F)F)c2)C1,,CC#N,,,,val
US20110130398A1,COc1cc(OCCS(C)(=O)=O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F>>COc1cc(OCCS(C)=O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F,,CCOC(C)=O,,CO,,val
US20090093483A1,CC(C)(C)OC(=O)CNC(=O)C1=C(O)C(C)(C)c2cc(/C=C/c3ccccc3)ccc2C1=O>>CC1(C)C(O)=C(C(=O)NCC(=O)O)C(=O)c2ccc(/C=C/c3ccccc3)cc21,,O=C(O)C(F)(F)F,,,,val
US05534481,CCS.Cn1nc2cccc(F)c2c1S(N)(=O)=O>>CCSc1cccc2nn(C)c(S(N)(=O)=O)c12,,CS(C)=O,,CC(C)(C)[O-].[K+],,val
US20080009530A1,CCOC(=O)/C=C/c1ccc(OCCOC)cc1O.ClCc1ccc(Cl)cc1Cl>>CCOC(=O)/C=C/c1ccc(OCCOC)cc1OCc1ccc(Cl)cc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20110028512A1,CC1(C)CCn2cncc2C1=O.COc1ccc([Mg]Br)cc1>>COc1ccc(C2(O)c3cncn3CCC2(C)C)cc1,,C1CCOC1,,Cl,,val
US06284902B1,CC(=O)O[C@H](CBr)CC(=O)O.CC(C)(C)N>>CC(C)(C)N.O=C(O)C[C@H]1CO1,,O,,,,val
US20140206663A1,C[C@@H]1C(=O)NN=C2COc3cc(-c4ccccc4F)ccc3N21.O=C1CCC(=O)N1Br>>C[C@@H]1C(=O)NN=C2COc3cc(-c4ccccc4F)c(Br)cc3N21,,O=C(O)C(F)(F)F,,,,val
US20090203692A1,COc1cc(N)ncn1.CSC1=NC(=O)/C(=C/c2ccc3ncccc3c2)S1>>COc1cc(NC2=NC(=O)/C(=C/c3ccc4ncccc4c3)S2)ncn1,,CC(=O)O,CCO,,,val
US06335459B1,CC(C)(C)OC(=O)COc1cccc(/C=C/COC(=O)N(c2ccccc2)c2ccccc2)c1>>O=C(O)COc1cccc(/C=C/COC(=O)N(c2ccccc2)c2ccccc2)c1,,C1CCOC1,CO,[Li+].[OH-],,val
US05929097,COC(=O)c1cccc(C=O)c1NS(=O)(=O)c1ccc(OC)cc1.ClCc1cccnc1>>COC(=O)c1cccc(C=O)c1N(Cc1cccnc1)S(=O)(=O)c1ccc(OC)cc1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US04965282,CCOC(=O)C(Br)Br.Cn1nccc1C(=O)c1cc(O)c(O)c(Cl)c1Cl>>CCOC(=O)C1Oc2cc(C(=O)c3ccnn3C)c(Cl)c(Cl)c2O1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050070592A1,Cc1c(-c2ccccc2)n(C)c2cccc(-c3ccc(OCC#N)cc3)c12.[N-]=[N+]=[N-]>>Cc1c(-c2ccccc2)n(C)c2cccc(-c3ccc(OCc4nnn[nH]4)cc3)c12,,CN(C)C=O,,[Cl-].[NH4+],,val
US20130158004A1,C[C@H](NC(=O)OC(C)(C)C)c1ccc(OC2CN(c3ncc(Br)cn3)C2)cc1>>C[C@H](N)c1ccc(OC2CN(c3ncc(Br)cn3)C2)cc1,,CO,,Cl,,val
US20060041003A1,CCCCC12CC(=O)C=C1c1ccc(OCOC)cc1C2.CCCI>>CCCC[C@]12Cc3cc(OCOC)ccc3C1=CC(=O)[C@H]2CCC,,C1CCOC1,CCOC(C)=O,CC(C)[N-]C(C)C.[Li+],,val
US20070010537A1,COC(=O)c1c(NC(=O)Nc2cccc(S(=O)(=O)N3CCCc4ccccc43)c2)cccc1[N+](=O)[O-]>>O=c1[nH]c2cccc([N+](=O)[O-])c2c(=O)n1-c1cccc(S(=O)(=O)N2CCCc3ccccc32)c1,,CO,,O,C[O-].[Na+],val
US20020147160A1,C=C[C@@]1(O)[C@H](OCc2ccc(Cl)cc2Cl)[C@@H](COCc2ccc(Cl)cc2Cl)O[C@H]1n1ccc2c(N)ncnc21>>C=C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1ccc2c(N)ncnc21,,ClCCl,,ClB(Cl)Cl,,val
US06107342,CCOC(=O)[C@H]1[C@@H]2C[C@@H](O)[C@@](N=[N+]=[N-])(C(=O)OCc3ccccc3)[C@@H]21>>N[C@@]1(C(=O)O)[C@H](O)C[C@@H]2[C@H]1[C@H]2C(=O)O,[Pd],CC(=O)O,O,,,val
US05240940,Fc1ccc(Oc2ccnc3cc(Cl)ccc23)c(Cl)c1.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1ccc(Oc2ccc(F)cc2Cl)c2ccc(Cl)cc21,,ClCCl,,,,val
US20060247250A1,CC(C)NCCO.O=C(Cl)c1cccc(Br)c1>>CC(C)N(CCO)C(=O)c1cccc(Br)c1,,ClCCl,,,,val
US20080019930A1,CCCCC(CC)CO.O=C(O)CNC(=O)c1ccccc1>>CCCCC(CC)COC(=O)CNC(=O)c1ccccc1,,Cc1ccccc1,,O=S(=O)(O)O,,val
US20140274701A1,ClCBr.Oc1cc(F)cc(F)c1O>>Fc1cc(F)c2c(c1)OCO2,,CCOCC,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20030166639A1,CC(C)(C)OC(=O)Nc1cc(C(F)(F)F)c(Cl)cc1NC(=O)CC(=O)c1cccc(-c2ccncc2)c1>>O=C1CC(c2cccc(-c3ccncc3)c2)=Nc2cc(C(F)(F)F)c(Cl)cc2N1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120028931A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.Cc1cc(C[Si](C)(C)C)on1>>Cc1cc(C=C2CCN(C(=O)OC(C)(C)C)CC2)on1,,C1CCOC1,,[Li]CCCC,,val
US20060264428A1,C[C@H](c1ccccc1)N1CC(O)[C@](C)(C(=O)OC(C)(C)C)C1.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)[C@]1(C)CN(C(=O)OCc2ccccc2)CC1O,,CCO,CCOCC,Cl,O=C([O-])O.[Na+],val
US20090137595A1,CC(=O)OCC(=O)Nc1cn2nc(Oc3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)ccc2n1>>O=C(CO)Nc1cn2nc(Oc3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)ccc2n1,,CO,,Cl,[Na+].[OH-],val
US20100160434A1,COC(=O)CS(=O)(=O)CCC(F)(F)F.Cc1ccc(S(=O)(=O)OCC=CC(F)(F)F)cc1>>COC(=O)C(CC=CC(F)(F)F)S(=O)(=O)CCC(F)(F)F,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20070167449A1,CN1CCN(c2ccc(N=C=S)cc2)CC1.NC(=O)Nc1ccc(OCCN2CCCC2)cc1>>CN1CCN(c2ccc(NC(N)=S)cc2)CC1,,CO,ClCCl,,,val
US20140350034A1,Cc1cc(NC(=O)OC(C)(C)C)nc(C)c1CN.Clc1cccc(Cl)c1Cc1nc2c(Cl)ncnc2o1>>Cc1cc(NC(=O)OC(C)(C)C)nc(C)c1CNc1ncnc2oc(Cc3c(Cl)cccc3Cl)nc12,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150080588A1,CC(C)(C)OC(=O)N[C@@H]1C=C[C@@](CO)(CCO)C1.O=C1c2ccccc2C(=O)N1[Se]c1ccccc1>>CC(C)(C)OC(=O)N[C@H]1C[C@]2(CO)CCO[C@@H]2[C@H]1[Se]c1ccccc1,,ClCCl,,FB(F)F,,val
US20070197558A1,N#Cc1ccc(Cl)c([N+](=O)[O-])c1.Oc1ccc(O)cc1>>N#Cc1ccc(Oc2ccc(O)cc2)c([N+](=O)[O-])c1,,CS(C)=O,,Cl,[K+].[OH-],val
US20050027119A1,CC(O)CO.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>CC(O)COC(=O)c1ccc([N+](=O)[O-])cc1,,Cc1ccccc1,,CCN(CC)CC,ClCCl,val
US20040248888A1,Cc1nc(C#Cc2ccnc(Cl)c2)c[nH]1.OB(O)c1ccc(Cl)cc1>>Cc1nc(C#Cc2ccnc(Cl)c2)cn1-c1ccc(Cl)cc1,,ClCCl,,,,val
US20040209881A1,COc1ccc(Nc2nc(Cl)nc(NC3CCCCCC3)n2)cc1Cl.Oc1ccccc1F>>COc1ccc(Nc2nc(NC3CCCCCC3)nc(Oc3ccccc3F)n2)cc1Cl,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100076029A1,CCOC(=O)C(C)(C)Br.SC1CCCC1>>CCOC(=O)C(C)(C)SC1CCCC1,,CCO,,[K+].[OH-],,val
US20060009524A1,NCc1ccccc1.O=C(O)C1OC1C1CCCCC1>>O=C(O)C(NCc1ccccc1)C(O)C1CCCCC1,,COC(C)(C)C,O,Cl,[Na+].[OH-],val
US20130296605A1,NNC(N)=S.O=C(c1ccccc1)c1ccc(C(=O)c2ccccc2)cc1>>NC(=S)NN=C(c1ccccc1)c1ccc(C(=O)c2ccccc2)cc1,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccco2)c1I.NCCc1ccc(O)cc1>>Nc1nc(NCCc2ccc(O)cc2)c(I)c(-c2ccco2)n1,,C1COCCO1,,,,val
US20150166564A1,CCOC(=O)c1nn(-c2ccccc2)c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)c(F)c2)c1C>>COCCN1C[C@@H](NC(=O)Nc2c(C)c(C(=O)O)nn2-c2ccccc2)[C@H](c2ccc(F)c(F)c2)C1,,C1CCOC1,CO,[Li+].[OH-],,val
US20060025459A1,CCCNCCC.COC(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1>>CCCN(CCC)C(=O)c1cc(C(=O)OC)cc([N+](=O)[O-])c1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20070197622A1,CC(c1cn(S(=O)(=O)N(C)C)c([Si](C)(C)C(C)(C)C)n1)c1cccc(F)c1F>>CC(c1c[nH]cn1)c1cccc(F)c1F,,Cl,,N,,val
US20060205715A1,NC(=O)c1ccc(Oc2ccc3c(c2)CCCC3=O)nc1>>NC(=O)c1ccc(Oc2ccc3c(c2)CCCC3O)nc1,,CO,,[BH4-].[Na+],,val
US20100273768A1,Cn1cc(-c2cccc(N3CCOc4cc(C(C)(C)C)ccc4C3=O)c2C=O)cc(Nc2ccc(C(=O)N3CCOCC3)cn2)c1=O>>Cn1cc(-c2cccc(N3CCOc4cc(C(C)(C)C)ccc4C3=O)c2CO)cc(Nc2ccc(C(=O)N3CCOCC3)cn2)c1=O,,C1CCOC1,CC(C)O,[BH4-].[Na+],,val
US20110039852A1,CCOC(=O)Cc1cc(OCc2ccccc2)ccc1Cl>>CCOC(=O)Cc1cc(O)ccc1Cl,,CCO,,,,val
US20160137636A1,COc1cc(Br)c(Cl)cc1-c1nccc2cc(S(=O)(=O)Nc3nncs3)ccc12.Cc1cc(B(O)O)ccc1Cl>>COc1cc(-c2ccc(Cl)c(C)c2)c(Cl)cc1-c1nccc2cc(S(=O)(=O)Nc3nncs3)ccc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[K+].[K+],,val
US20110053921A1,BrCC1CC1.CC12COCCN1c1nc(Cl)ncc1NC2=O>>CC12COCCN1c1nc(Cl)ncc1N(CC1CC1)C2=O,,CS(C)=O,O,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20050026935A1,Clc1nc(NCc2ccccn2)c2c(-c3ccccc3)csc2n1.NCC1CC1>>c1ccc(-c2csc3nc(NCC4CC4)nc(NCc4ccccn4)c23)cc1,,O,,,,val
US20010027196A1,CN(C)C(=O)Oc1ccc(CO)nc1.CS(=O)c1nc(N)nc(-c2ccco2)c1C#N>>CN(C)C(=O)Oc1ccc(COc2nc(N)nc(-c3ccco3)c2C#N)nc1,,COCCOC,,C1CCC2=NCCCN2CC1,,val
US20140171403A1,NCCC1CCN(C(=O)/C=C/c2cc(Cl)cc(Cl)c2)CC1.O=C(O)c1c[nH]c(=O)o1>>O=C(NCCC1CCN(C(=O)/C=C/c2cc(Cl)cc(Cl)c2)CC1)c1c[nH]c(=O)o1,,CCOC(C)=O,CN(C)C=O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US20070213331A1,COc1cccc(O[C@@H]2C[C@H]([C@@H](O)[C@H](Cc3cc(F)cc(F)c3)NC(C)=O)N(C(=O)OC(C)(C)C)C2)c1.Cl>>COc1cccc(O[C@H]2CN[C@@H]([C@@H](O)[C@H](Cc3cc(F)cc(F)c3)NC(C)=O)C2)c1.Cl,,C1COCCO1,,,,val
US04322414,CCSP(=O)(Cl)Oc1cccc(SC)c1.O=C1CCc2c(O)ccc(Br)c21>>CCSP(=O)(Oc1cccc(SC)c1)Oc1ccc(Br)c2c1CCC2=O,,Cc1ccccc1,,CCN(CC)CC,,val
US05733912,Cl.Fc1ncccc1C12CCCN1CCC2>>Cl.Fc1ncccc1C12CCCN1CCC2,,CCOCC,,,,val
US20020002183A1,Nc1ccc(Br)cn1.O=C(O)c1cc(F)ccc1[N+](=O)[O-]>>O=C(Nc1ccc(Br)cn1)c1cc(F)ccc1[N+](=O)[O-],,c1ccncc1,,O=P(Cl)(Cl)Cl,,val
US20140155391A1,COC(=O)c1cc(CN)ccc1OC.CS(=O)(=O)Cl>>COC(=O)c1cc(CNS(C)(=O)=O)ccc1OC,,ClCCl,,c1ccncc1,,val
US20120028994A1,CCOC(=O)C1CCC(c2ccc(C(F)(F)F)nc2)C1=O.NC(N)=O>>Oc1nc(O)c2c(n1)C(c1ccc(C(F)(F)F)nc1)CC2,,CO,,O,,val
US04940714,Cn1cnc2cnc3ccccc3c21.O=C(Cl)C1CC1>>Cn1c(C(=O)C2CC2)nc2cnc3ccccc3c21,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20120041024A1,Cc1[nH]nc(NC=O)c1C>>CNc1n[nH]c(C)c1C,,C1CCOC1,,B,,val
US20150336876A1,NCCCC[C@@H](Oc1ccc(C(F)(F)F)cc1)c1ccccc1.O=C(O)/C=C/C(=O)O>>NCCCC[C@@H](Oc1ccc(C(F)(F)F)cc1)c1ccccc1.O=C(O)/C=C/C(=O)O,,CCO,,,,val
US20150158847A1,CCOC(=O)Nc1nc2cc(I)cnc2n1C(C)c1ccc(OCc2ccc(C(F)(F)F)nc2)c(OC)c1>>COc1cc(C(C)n2c(N)nc3cc(I)cnc32)ccc1OCc1ccc(C(F)(F)F)nc1,,CCO,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20050038068A1,N#Cc1c(O)c2c(-c3ccc([N+](=O)[O-])cc3)csc2[nH]c1=O>>N#Cc1c(O)c2c(-c3ccc(N)cc3)csc2[nH]c1=O,[Fe],CCO,,O,[Cl-].[NH4+],val
US20120119157A1,COc1cscc1CCO.Cc1ccc(S(=O)(=O)Cl)cc1>>COc1cscc1CCOS(=O)(=O)c1ccc(C)cc1,,ClCCl,,c1ccncc1,,val
US20140121187A1,CCCC(=O)NC1(c2ccc(C(C)C)cc2OC(=O)CCC)C(=O)c2cccc([N+](=O)[O-])c2C1=O>>CCCC(=O)NC1(c2ccc(C(C)C)cc2OC(=O)CCC)C(=O)c2cccc(N)c2C1=O,[Fe],CCO,,Cl,O,val
US20050159462A1,C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)C=Cc1cccc2oc(-c3ccc(Cl)cc3)nc12>>C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)CCc1cccc2oc(-c3ccc(Cl)cc3)nc12,[Pd],CCOC(C)=O,,,,val
US05741796,CI.O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)OCc1ccccc1>>COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US04975431,Cc1ccc(C=O)cc1.Cc1ccc2c(n1)CCCCC2>>Cc1ccc(C(O)Cc2ccc3c(n2)CCCCC3)cc1,,CCCCCC,Cc1ccccc1,O,[Li]CCCC,val
US20080167311A1,O=C(O)CCC/C=C\C[C@H]1[C@H](Cl)C[C@@H](O)[C@@H]1COc1cc(Cl)cc(Cl)c1.OCCO>>O=C(CCC/C=C\C[C@H]1[C@H](Cl)C[C@@H](O)[C@@H]1COc1cc(Cl)cc(Cl)c1)OCCO,,ClCCl,,CCN(CC)CC,CCOC(=O)Cl,val
US20080064872A1,C1COCCN1.Cc1ccc(-c2cc(C#N)c(Cl)nc2-c2ccccc2)cc1>>Cc1ccc(-c2cc(C#N)c(N3CCOCC3)nc2-c2ccccc2)cc1,,CN(C)C=O,,,,val
US06548506B2,CCI.CCOC(=O)c1cn(C)c2nc3cc(NC4CCCCC4)c(F)cc3cc2c1=O>>CCN(c1cc2nc3c(cc2cc1F)c(=O)c(C(=O)O)cn3C)C1CCCCC1,,CN(C)C=O,,[H-].[Na+],,val
US20130261077A1,CNC(=O)c1cccc(C)c1.O=C1CCC(=O)N1Br>>CNC(=O)c1cccc(CBr)c1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20080221201A1,NC1CC1.O=S(=O)(Cl)c1ccc(Br)cc1OC(F)(F)F>>O=S(=O)(NC1CC1)c1ccc(Br)cc1OC(F)(F)F,,ClCCl,,,,val
US20050240021A1,COc1cc(C(=O)CBr)ccc1-c1ccccn1.Nc1ccccn1>>COc1cc(-c2cn3ccccc3n2)ccc1-c1ccccn1,,CCO,,,,val
US20030069246A1,CC(=O)O.CCOC(C)=N.COc1cc(C)c(-c2c(C)n[nH]c2N)c(C)c1>>CC(=O)O.COc1cc(C)c(-c2c(C)n[nH]c2NCC=N)c(C)c1,,CC#N,,,,val
US20030158185A1,Brc1ccoc1.COCNC(=O)CCNC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NCCC(=O)c1ccoc1,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US05591850,CCCCC(CC)CBr.N#Cc1ccc(O)cc1>>CCCCC(CC)COc1ccc(C#N)cc1,,COCCO,,[Na+].[OH-],,val
US20150376189A1,Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1.NC(=O)Cc1ccccn1>>O=C(Cc1ccccn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1,,CN(C)C=O,,[H-].[Na+],,val
US20090318523A1,CCOC(=O)C(C(=O)OCc1ccccc1)c1ccc([N+](=O)[O-])c(C(F)(F)F)c1>>CCOC(=O)Cc1ccc(N)c(C(F)(F)F)c1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20040010009A1,CC(C)(C)OC(=O)N1CCC(O)CC1.O=[N+]([O-])c1cc(F)c(O)c(F)c1>>CC(C)(C)OC(=O)N1CCC(Oc2c(F)cc([N+](=O)[O-])cc2F)CC1,,ClCCl,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030119890A1,CC(N)C(C)(C)C.N#Cc1cccc(N=C=S)c1>>CC(NC(=S)Nc1cccc(C#N)c1)C(C)(C)C,,C1CCOC1,,,,val
US05340808,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1cc([N+](=O)[O-])ccc1N>>CCOC(=O)c1cc([N+](=O)[O-])ccc1NC(=O)OC(C)(C)C,CN(C)c1ccncc1,C1CCOC1,,,,val
US20160176816A1,CC(C)Br.O=C(Nc1ccccc1-c1ccc(F)c(Cl)c1)OC[C@@H]1CCNC1>>CC(C)N1CC[C@@H](COC(=O)Nc2ccccc2-c2ccc(F)c(Cl)c2)C1,,C1CCOC1,,CCN(CC)CC,,val
US04904671,C=C1CC(=O)O1.Cc1nc2cnccc2n1CCCCO>>CC(=O)CC(=O)OCCCCn1c(C)nc2cnccc21,,CC(C)=O,,,,val
US04873344,N#CCc1ccc(F)cc1.N#Cc1ccccc1Cl>>N#Cc1ccccc1C(C#N)c1ccc(F)cc1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20090264406A1,C=O.CC(c1ccc2ncccc2c1Cl)c1cnc2ccc(-c3cnn(C4CCNCC4)c3)nn12>>CC(c1ccc2ncccc2c1Cl)c1cnc2ccc(-c3cnn(C4CCN(C)CC4)c3)nn12,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
USRE037729E1,CC(=O)c1ccc(OCCCBr)c(Br)c1.Fc1ccc2c(C3CCNCC3)noc2c1>>CC(=O)c1ccc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)c(Br)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100009957A1,O=C(NC1CN(Cc2ccccc2)CCN(Cc2ccccc2)C1)ON1C(=O)CCC1=O.O=C1[C@H]2NCC[C@H]2N1S(=O)(=O)O>>O=C(NC1CN(Cc2ccccc2)CCN(Cc2ccccc2)C1)N1CC[C@@H]2[C@H]1C(=O)N2S(=O)(=O)O,,CC#N,O,O=C([O-])O.[Na+],,val
US20150094492A1,CC(C)c1ccc([N+](=O)[O-])cc1Br.Cl>>CC(C)c1ccc(N)cc1Br.Cl,,O,,,,val
US20100286152A1,O=C(O)Cc1ccccc1Cl.O=C1CCC(=O)N1Br>>O=C(O)C(Br)c1ccccc1Cl,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US04798837,CC(=O)Nc1cc(Cl)c(O)cc1Cl.FC(F)=C(F)C(F)(F)F>>CC(=O)Nc1cc(Cl)c(OC(F)(F)C(F)C(F)(F)F)cc1Cl,,CN(C)C=O,,[K+].[OH-],,val
US20070232627A1,COC(=O)c1ccc(Sc2ccc(N)c(F)c2)c([N+](=O)[O-])c1.O=C(Cl)OCC(Cl)(Cl)Cl>>COC(=O)c1ccc(Sc2ccc(NC(=O)OCC(Cl)(Cl)Cl)c(F)c2)c([N+](=O)[O-])c1,,ClCCl,,c1ccncc1,,val
US20100305096A1,Fc1cccnc1Br.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1cccc(F)c1Br,,ClC(Cl)Cl,,,,val
US05559113,NCCc1c[nH]cn1.O=[N+]([O-])c1ccc(Cl)cc1>>O=[N+]([O-])c1ccc(NCCc2c[nH]cn2)cc1,,CC(C)O,,,,val
US20150166480A1,CCOC(=O)c1ccc(-c2ncc(OCC3CCN(CC(C)(C)F)CC3)cn2)cc1F>>CC(C)(F)CN1CCC(COc2cnc(-c3ccc(C(=O)O)c(F)c3)nc2)CC1,,C1CCOC1,O,[Li]O,,val
US05599930,C#CC(C)(C)N1CCN(C(=O)OC(C)(C)C)CC1>>CCC(C)(C)N1CCN(C(=O)OC(C)(C)C)CC1,O=[Pt],CCO,,,,val
US20060173019A1,COCN(c1cc(Cl)cnc1C(=O)N1CC(C)OC(C)C1)S(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>CC1CN(C(=O)c2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)CC(C)O1,,Cl,O,,,val
US20100152450A1,CC(C)(C)OC(=O)N1CC[C@H](CCCOCc2ccccc2)C1>>c1ccc(COCCC[C@H]2CCNC2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100193736A1,CC1c2cc(O)ccc2-c2ccc(O)cc21.Cc1ccccc1C.O=C(O)c1ccc(O)cc1.OB(O)O>>CC1c2cc(OC(=O)c3ccc(O)cc3)ccc2-c2ccc(OC(=O)c3ccc(O)cc3)cc21,,Cc1ccccc1C,,O=S(=O)(O)O,,val
US03954852,CS(=O)c1ccc(N)cc1.O=[N+]([O-])c1ccc(F)cc1I>>CS(=O)c1ccc(C2=CC(F)=CCC2(N)[N+](=O)[O-])cc1,[Cu],,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06018046,CCC(=O)CBr.O=c1c(Cc2cccnc2)cn2c3ccc(Br)cc3c3cc(O)cc1c32>>CCC(=O)COc1cc2c(=O)c(Cc3cccnc3)cn3c4ccc(Br)cc4c(c1)c23,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04262005,CC(C)C(=O)Cl.Clc1ccc(N=C2NCCN2)c(Cl)c1>>CC(C)C(=O)N1CCNC1=Nc1ccc(Cl)cc1Cl,,C1CCOC1,,O,,val
US20120015962A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(N)C1CCN(c2ccc(Cl)cc2[N+](=O)[O-])C1>>CC(NC(=O)OC(C)(C)C)C1CCN(c2ccc(Cl)cc2[N+](=O)[O-])C1,,ClCCl,,,,val
US20080045554A1,CCCCCN=C=S.N>>CCCCCNC(N)=S,,CO,,,,val
US20090048252A1,COC(=O)c1ccc(N)c(N)c1.O=Cc1ccccc1>>COC(=O)c1ccc2nc(-c3ccccc3)[nH]c2c1,,CCO,O,O=S([O-])O.[Na+],,val
US20110070317A1,CC(C)(C)OC(=O)N[C@@H]1CCCNC1.O=C(Nc1c[nH]c2ncc(Cl)c(F)c12)C1CCCC1>>CC(C)(C)OC(=O)N[C@@H]1CCCN(c2c(Cl)cnc3[nH]cc(NC(=O)C4CCCC4)c23)C1,,CCC(C)O,,,,val
US20070287711A1,CN(C)C(=O)c1cc(-c2cnc3c(c2)c(Cc2cccc(Cl)c2)nn3COC(=O)C(C)(C)C)ccc1NC(=O)N1CCOCC1>>CN(C)C(=O)c1cc(-c2cnc3[nH]nc(Cc4cccc(Cl)c4)c3c2)ccc1NC(=O)N1CCOCC1,,C1CCOC1,CO,[Na+].[OH-],,val
US20110288071A1,CN1Cc2cccc(O)c2C1=O.Clc1ncc(Cl)c(Cl)n1>>CN1Cc2cccc(Oc3nc(Cl)ncc3Cl)c2C1=O,,ClCCl,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050014685A1,Brc1ccc(-c2ccc(N3CCN(C4CCCCC4)CC3)cc2)cc1.CCOC(=O)c1ccc(B(O)O)cc1>>CCOC(=O)c1ccc(-c2ccc(-c3ccc(N4CCN(C5CCCCC5)CC4)cc3)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100093711A1,CC1(C)CN(C(=O)c2ccccc2)c2ccccc2C1=O>>CC1(C)CN(C(=O)c2ccccc2)c2ccccc2C1O,,CO,,[BH4-].[Na+],,val
US20150051395A1,COC(=O)c1cc(F)c(NS(=O)(=O)c2ccc(N)cc2)cc1F.O=CNNC=O>>COC(=O)c1cc(F)c(NS(=O)(=O)c2ccc(-n3cnnc3)cc2)cc1F,,c1ccncc1,,CCN(CC)CC,C[Si](C)(C)Cl,val
US20060293354A1,Cc1ccc(N)c(Cl)c1.O=C(NCC1CCCCC1)c1cnc(Cl)nc1C(F)(F)F>>Cc1ccc(Nc2ncc(C(=O)NCC3CCCCC3)c(C(F)(F)F)n2)c(Cl)c1,,C1COCCO1,,,,val
US05593983,CC1(C)CN([C@H]2C[C@@]3(C)[C@@H](CC[C@H]4[C@@H]5CC[C@H](C#N)[C@@]5(C)CC[C@@H]43)C[C@@H]2O)CCO1.CS(=O)(=O)O>>CC1(C)CN([C@H]2C[C@@]3(C)[C@@H](CC[C@H]4[C@@H]5CC[C@H](C#N)[C@@]5(C)CC[C@@H]43)C[C@@H]2O)CCO1.CS(=O)(=O)O,,CCO,,,,val
US20150025068A1,COC(=O)c1ccc(NS(=O)(=O)c2cc(-c3ccc4c(c3)OCO4)c(Cl)s2)cc1O>>O=C(O)c1ccc(NS(=O)(=O)c2cc(-c3ccc4c(c3)OCO4)c(Cl)s2)cc1O,,[Na+],[OH-],CCOCC,O,val
US04873244,CN.O=c1[nH]c2ccccc2c(=O)o1>>Cn1c(=O)[nH]c2ccccc2c1=O,,C1CCOC1,,,,val
US06211227B1,COC(=O)c1c(CSc2cccc(OC)c2)cccc1[N+](=O)[O-]>>COc1cccc(SCc2cccc([N+](=O)[O-])c2C(=O)O)c1,,CO,,[Na+].[OH-],,val
US20150099730A1,O=C(Cl)C1CC1.O=C1N(C[C@@H]2CCNC2)C(c2ccc(Br)cc2)=NC12CCN(Cc1ccccc1)CC2>>O=C(C1CC1)N1CC[C@@H](CN2C(=O)C3(CCN(Cc4ccccc4)CC3)N=C2c2ccc(Br)cc2)C1,,ClCCl,,CCN(CC)CC,CO,val
US04123614,O=[N+]([O-])C1(O)C=CC=CC1.OCC1CO1>>O=[N+]([O-])c1ccc(OCC(O)CO)cc1,,CO,,C[O-].[Na+],,val
US20160198708A1,NCC(F)(F)c1ncc(Br)cc1Cl.O=C(Cl)c1ccccc1C(F)(F)F>>O=C(NCC(F)(F)c1ncc(Br)cc1Cl)c1ccccc1C(F)(F)F,,ClCCl,O,,,val
US20060257987A1,CN(C)C=O.COC(=O)CCc1ccc(OCC[C@H](C)OS(C)(=O)=O)cc1.Oc1ncc(C(F)(F)F)cc1Oc1ccccc1>>COC(=O)CCc1ccc(OCC[C@H](C)Oc2ncc(C(F)(F)F)cc2Oc2ccccc2)cc1C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050107410A1,CC(=O)Nc1cccc(C(C2CCN(CCOc3cccc4nc(C)ccc34)CC2)N(C)CCCl)c1>>Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)CC5=O)c4)CC3)cccc2n1,,CN(C)C=O,,[H-].[Na+],,val
US04673746,CCOC(CBr)OCC.Oc1ccc2c(-c3ccccc3F)noc2c1Cl>>CCOC(COc1ccc2c(-c3ccccc3F)noc2c1Cl)OCC,,CN(C)C=O,,[H-].[Na+],,val
US20070043081A1,CNCc1ccccc1.O=C(OCc1ccccc1)N1CCC(C(=O)O)(c2ccccc2)CC1>>CN(Cc1ccccc1)C(=O)C1(c2ccccc2)CCN(C(=O)OCc2ccccc2)CC1,,ClC(Cl)Cl,,CCN(C(C)C)C(C)C,O=S(Cl)Cl,val
US05665748,CC1=CNC(CCl)(c2ccccc2)O1.O=Cc1cccc(O)c1>>Cc1oc(-c2ccccc2)nc1COc1cccc(C=O)c1,,O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20060009518A1,CC(C)(C)OC(=O)NC1CC2SCC(C(N)=O)N2C1=O>>CC(C)(C)OC(=O)NC1CC2SCC(C#N)N2C1=O,,C1CCOC1,,CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC,,val
US20010014691A1,CCN.ClCCCOc1cccnc1>>CCNCCCOc1cccnc1,,C1CCOC1,CO,,,val
US20150344423A1,COC(=O)c1ccc(CC2CCCCC2)[nH]1.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Br)c(CC2CCCCC2)[nH]1,,ClC(Cl)Cl,,[Na+].[OH-],,val
US05350760,COC(=O)CC1(CS[C@H](CCc2ccccc2C(C)(C)O)c2cccc(CO)c2)CC1>>COC(=O)CC1(CS[C@H](CCc2ccccc2C(C)(C)O)c2cccc(C=O)c2)CC1,O=[Mn]=O,CCOC(C)=O,,,,val
US20160207926A1,CCn1c(C(=O)NCC(F)(F)F)nc2c(N[C@H]3CCN(C(=O)OC(C)(C)C)C3)ncnc21>>CCn1c(C(=O)NCC(F)(F)F)nc2c(N[C@H]3CCNC3)ncnc21,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110281908A1,O=[N+]([O-])c1cnc(Nc2ccccc2O)c([N+](=O)[O-])c1>>O=[N+]([O-])c1cnc2c(c1)Oc1ccccc1N2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100137278A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Fc1ccc2nc[nH]c2c1>>CC(C)(C)OC(=O)n1cnc2ccc(F)cc21,,ClCCl,,CCN(CC)CC,,val
US05322847,Cc1ccc2ccc(Cl)cc2n1.O=Cc1cccc(C=O)c1>>O=Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1,,Cc1ccccc1C,,CC(=O)OC(C)=O,,val
US04499091,CC(=O)OC=O.CNn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(C)CC3)cc21>>CN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3NCC=O)CC1,,O=CO,,CC(=O)OC(C)=O,,val
US20090281142A1,C=CCOC(=O)Nc1nc(C(=O)C(=O)OCC)cs1.C[Mg]Br>>C=CCOC(=O)Nc1nc(C(C)(O)C(=O)OCC)cs1,,C1CCOC1,,[Cl-].[NH4+],,val
US20070117816A1,CCS(=O)(=O)c1cccc(B(O)O)c1.COc1c(N)cc(Br)c2c1[nH]c1ncc(C)cc12>>CCS(=O)(=O)c1cccc(-c2cc(N)c(OC)c3[nH]c4ncc(C)cc4c23)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US05225431,CC(=O)Nc1ccc(CCO)cc1.O=C1NC(=O)C(Cc2ccc([N+](=O)[O-])cc2)N1>>CC(=O)Nc1ccc(CCN2C(=O)NC(Cc3ccc([N+](=O)[O-])cc3)C2=O)cc1,,COCCOC,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US07037911B2,CC[C@@H]1C[C@@H](C(O[SiH2]C(C)(C)C)(c2ccccc2)c2ccccc2)N(C(=O)OC(C)(C)C)C1=O>>CC[C@@H]1C[C@@H](CO)N(C(=O)OC(C)(C)C)C1=O,,C1CCOC1,CCOC(C)=O,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US05665730,Cc1cccc([N+](=O)[O-])c1CCl.Cc1nc2c(N)cccn2c1C>>Cc1cccc([N+](=O)[O-])c1CNc1cccn2c(C)c(C)nc12,,CC(C)=O,,[I-].[Na+],,val
US20120165304A1,O=C(OCc1ccccc1)N1CCc2nc3ccnn3c(O)c2CC1.O=P(Cl)(Cl)Cl>>O=C(OCc1ccccc1)N1CCc2nc3ccnn3c(Cl)c2CC1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US20060142581A1,O=C(NCCCCc1ccc(NC[C@@H](O)CO)cc1)OCc1ccccc1>>NCCCCc1ccc(NC[C@@H](O)CO)cc1,[Pd],CO,,,,val
US20090253687A1,COC(=O)COc1c(F)cc(Br)cc1[N+](=O)[O-]>>O=C1COc2c(F)cc(Br)cc2N1,[Zn],CC(=O)O,,,,val
US04016280,CN1CCC(O)(c2ccccc2)C(C(=O)c2ccccc2)C1>>CN1CCC(c2ccccc2)(c2ccccc2)CC1,,c1ccccc1,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20150191439A1,NC12CC3CC(CC(C3)C1)C2.O=C(CBr)c1cccs1>>O=C(CNC12CC3CC(CC(C3)C1)C2)c1cccs1,,C1CCOC1,,,,val
US20090264399A1,CN[C@H]1CN(Cc2ccccc2)CC[C@H]1C.Nc1nccc(Cl)c1[N+](=O)[O-]>>C[C@@H]1CCN(Cc2ccccc2)C[C@@H]1N(C)c1ccnc(N)c1[N+](=O)[O-],,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20040186127A1,CC(C)(C)OC(=O)N1CCc2cc(N)ccc21.O=C(Cl)c1ccccc1>>CC(C)(C)OC(=O)N1CCc2cc(NC(=O)c3ccccc3)ccc21,,ClCCl,,CCN(CC)CC,,val
US20080015203A1,COC[C@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)OC)c1>>COC[C@H](C)Oc1cc(O)cc(C(=O)OC)c1,,C1CCOC1,,,,val
US20160194315A1,COC(=O)c1ccnc2cc(C(C)O)[nH]c12>>CC(O)c1cc2nccc(C(=O)O)c2[nH]1,,CC#N,O,,,val
US20120214803A1,O=C(c1ccc(C(F)(F)F)nc1)c1ccc2cccnc2c1[N+](=O)[O-]>>Nc1c(C(=O)c2ccc(C(F)(F)F)nc2)ccc2cccnc12,[Pd],C1CCOC1,,,,val
US20100063294A1,COC(=O)[C@@H](C)Cc1ccccc1>>C[C@H](CO)Cc1ccccc1,,C1CCOC1,,[H][H],,val
US20060004043A1,CCOC(=N)c1ccc2[nH]nc(-c3ccc4cc(OCc5ccccn5)ccc4c3)c2c1.NNC(=O)CN1CCOCC1>>c1ccc(COc2ccc3cc(-c4n[nH]c5ccc(-c6n[nH]c(CN7CCOCC7)n6)cc45)ccc3c2)nc1,,CCO,,CCN(CC)CC,Cl,val
US20120094964A1,COC(=O)c1ccc(S(=O)(=O)NCCc2ccccc2)cc1.FC(F)(F)c1cnc(Cl)c(Cl)c1>>COC(=O)c1ccc(S(=O)(=O)N(CCc2ccccc2)c2ncc(C(F)(F)F)cc2Cl)cc1,,CC#N,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20020193367A1,COC(=O)c1cccc(C(=O)C(C)Br)c1.NC=S>>COC(=O)c1cccc(-c2ncsc2C)c1,,CCO,,,,val
US20030144263A1,CCOC(=O)Cl.Nc1ccc(-n2cccc2)cc1>>CCOC(=O)Nc1ccc(-n2cccc2)cc1,,c1ccncc1,,,,val
US20020045630A1,Cc1ccc2c(c1C)NCC2.Clc1ncnc2cnccc12>>Cc1ccc2c(c1C)N(c1ncnc3cnccc13)CC2,,CC(C)O,,c1ccncc1,,val
US20060041137A1,CC(C)C1=NNC(=O)C1.[O-][n+]1ccc(Cl)c2ccccc21>>CC(C)C1=NNC(=O)/C1=C1/C=C(Cl)c2ccccc2N1,,CC(=O)OC(C)=O,,,,val
US20090137607A1,O=C1CCC(=O)N1Br.O=Cc1ccc(-c2nc3nccn3cc2-c2ccccc2)cc1>>O=Cc1ccc(-c2nc3ncc(Br)n3cc2-c2ccccc2)cc1,,ClC(Cl)Cl,,,,val
US20050143443A1,CCOC(=O)c1[nH]cc(CCc2ccc(Cl)cc2)c1C>>Cc1c(CCc2ccc(Cl)cc2)c[nH]c1C(=O)O,,C1COCCO1,O,[Na+].[OH-],,val
US20030013875A1,CC1(c2cccc(N)c2)C2CN(CCCC3CCCCC3)CC21.CS(=O)(=O)Cl>>CC1(c2cccc(NS(C)(=O)=O)c2)C2CN(CCCC3CCCCC3)CC21,,ClCCl,,c1ccncc1,,val
US20120202690A1,C=CCN.COC(=O)c1nc(Cl)nc(Cl)c1Cl>>C=CCNc1nc(Cl)nc(C(=O)OC)c1Cl,,COCCOC,,CCN(CC)CC,O,val
US20080312226A1,CC(C)(C)OC(=O)N1CCNCC1.Clc1nc(-c2ccsc2)ns1>>CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccsc3)ns2)CC1,,CN(C)C=O,,CCN(CC)CC,O,val
US20100305142A1,Cc1cccc(C)c1Nc1c(-c2ccccc2C(=O)NNC(=O)OC(C)(C)C)nc2ccc(F)cn12>>Cc1cccc(C)c1Nc1c(-c2ccccc2C(=O)NN)nc2ccc(F)cn12,,C1COCCO1,Cl,,,val
US20080139561A1,CC(C)Oc1cc(N)n[nH]1.N#Cc1cc(F)c(F)nc1F>>CC(C)Oc1cc(Nc2nc(F)c(C#N)cc2F)n[nH]1,,CC#N,O,CCN(CC)CC,,val
US20140275015A1,Cc1cc(Cl)c([N+](=O)[O-])c(Cl)n1.Nc1cnccn1>>Cc1cc(Nc2cnccn2)c([N+](=O)[O-])c(Cl)n1,,CS(C)=O,,[Cl-].[NH4+],CC(C)(C)[O-].[K+],val
US05990102,COC(=O)CN1C(=O)CC1SCc1ccccc1>>O=C(O)CN1C(=O)CC1SCc1ccccc1,,CO,,[Na+].[OH-],,val
US05346913,C#CCNC(C)C(=O)OC.O=C=Nc1cc(Cl)cc(Cl)c1>>C#CCN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)C1C,,Cc1ccccc1,,,,val
US20100216746A1,CC(C)(C)OC(=O)C(C(=O)OC(C)(C)C)c1ccc([N+](=O)[O-])c(Oc2cc(Cl)cc(Br)c2)c1F>>O=C(O)Cc1ccc([N+](=O)[O-])c(Oc2cc(Cl)cc(Br)c2)c1F,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080207688A1,Cc1c(OC2CCNCC2)ccc(Cl)c1Cl.Cc1ccc(S(=O)(=O)OCC2CCN(C(=O)OC(C)(C)C)CC2)cc1>>Cc1c(OC2CCN(CC3CCN(C(=O)OC(C)(C)C)CC3)CC2)ccc(Cl)c1Cl,,CC#N,O,Cl,O=C([O-])[O-].[K+].[K+],val
US04567189,COc1ccc(CCl)cc1.COc1ccc(COCC(N)Cn2ccnc2)cc1>>COc1ccc(CNC(COCc2ccc(OC)cc2)Cn2ccnc2)cc1,,CC#N,,CCN(CC)CC,,val
US20060160877A1,Nc1cccc(-c2cccc3cc(C(=O)N[C@H]4CN5CCC4CC5)oc23)c1.O=C(Cl)C1CCC1>>Cl.O=C(N[C@H]1CN2CCC1CC2)c1cc2cccc(-c3cccc(NC(=O)C4CCC4)c3)c2o1,,C1CCOC1,,CCN(CC)CC,O,val
US20090176786A1,CN(C(=O)Cl)c1ccc(SC(F)(F)F)cc1F.NCc1cnc(Cl)s1>>CN(C(N)=O)c1ccc(SC(F)(F)F)cc1F,,COC(C)(C)C,,CCN(CC)CC,,val
US20130005716A1,COc1cc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)[C@@H]2SCCN2C(=O)OC(C)(C)C)ccc1OC(F)F.Cl>>COc1cc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)[C@H]2NCCS2)ccc1OC(F)F.Cl,,CCOC(C)=O,,,,val
US20110172209A1,CS(=O)(=O)Cl.O=[N+]([O-])c1ccc(O)nc1NC1CCCCC1>>CS(=O)(=O)Oc1ccc([N+](=O)[O-])c(NC2CCCCC2)n1,,ClCCl,,CCN(CC)CC,Cl,val
US20160237075A1,COC(=O)c1ccc(-c2nc(C3CCN(C(=O)OC(C)(C)C)CC3)ccc2C(N)=O)cc1>>CC(C)(C)OC(=O)N1CCC(c2ccc(C(N)=O)c(-c3ccc(C(=O)O)cc3)n2)CC1,,C1CCOC1,O,[Li+].[OH-],,val
US05658938,CC(=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.COc1cccc(C=O)c1OC>>COc1cccc(C=CC(=O)c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)c1OC,,CCO,,Cl,[Na+].[OH-],val
US20160122356A1,CC(C)OC(=O)[C@@H](N)Cc1ccccc1.O=P(Cl)(Cl)Oc1ccccc1.O=[N+]([O-])c1ccc(O)cc1>>CC(C)OC(=O)[C@H](Cc1ccccc1)NP(=O)(Oc1ccccc1)Oc1ccc([N+](=O)[O-])cc1,,ClCCl,,CCN(CC)CC,Cl,val
US04390699,CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5.Clc1nnnn1-c1ccccc1>>CN1CC[C@]23c4c5ccc(Oc6nnnn6-c6ccccc6)c4OC2C(=O)CC[C@@]3(O)[C@H]1C5,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050176772A1,CCOS(=O)(=O)c1ccc(C)cc1.COC(=O)[C@@H]1CNC[C@H]1c1ccc(F)cc1F>>CCN1C[C@@H](C(=O)OC)[C@H](c2ccc(F)cc2F)C1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080242675A1,ClCc1cnc(Cl)cc1Cl>>Cc1cnc(Cl)cc1Cl,[Ni],CCO,CCOC(C)=O,CCN(CC)CC,O,val
US20100120799A1,BrCCCC1CCOC1.CCCCNc1nc(N)c2nc(OC)nc-2[nH]1>>CCCCNc1nc(N)c2nc(OC)n(CCCC3CCOC3)c2n1,,CN(C)C=O,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US04882330,COc1cc(N2CCNCC2)cc(OC)c1OC.O=C(O)C(=O)O.OC(CCCl)COc1ccccc1>>COc1cc(N2CCN(CCC(O)COc3ccccc3)CC2)cc(OC)c1OC.O=C(O)C(=O)O,,CCCCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20080090825A1,CCC(O)(C(=O)O)C(Cc1ccccc1)C(=O)O>>CCC1=C(Cc2ccccc2)C(=O)OC1=O,,CC(=O)OC(C)=O,,,,val
US20070287708A1,COc1ccc(-c2cncc(C#N)c2Cl)cc1OC.Cc1ccc(N)c2[nH]ccc12>>COc1ccc(-c2cncc(C#N)c2Nc2ccc(C)c3cc[nH]c23)cc1OC,,CCO,,[NH4+].[OH-],,val
US20100286112A1,CC(C)c1noc(N2CCC(CCCOS(C)(=O)=O)CC2)n1.COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C>>CC(C)c1noc(N2CCC(CCCOc3ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc3)CC2)n1,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040029734A1,CC(Cl)Cl.COc1c(Cl)cc(F)c(-n2ncc(C(F)(F)F)cc2=O)c1N.C[S+](C)[B-](Br)(Br)Br>>CC(C)(C)c1nc2c(-n3ncc(C(F)(F)F)cc3=O)c(F)cc(Cl)c2o1,,CC(Cl)Cl,,O,,val
US20150299189A1,CC(C)(C)[Si](C)(C)Oc1cccc(CBr)c1.COC(=O)c1cc(Cl)ccc1Nc1ccc2[nH]ccc2c1>>COC(=O)c1cc(Cl)ccc1Nc1ccc2c(ccn2Cc2cccc(O[Si](C)(C)C(C)(C)C)c2)c1,,CC(=O)N(C)C,CCOC(C)=O,Cl,CC(C)(C)[O-].[K+],val
US20060025430A1,Nc1ccccc1.O=[N+]([O-])c1cc2c(Cl)ncnc2cc1F>>O=[N+]([O-])c1cc2c(Nc3ccccc3)ncnc2cc1F,,CC(C)O,,,,val
US06262095B1,NC1=C(Cl)C(=O)c2ccccc2C1=O.O=C(Cl)c1ccccc1Cl>>O=C1c2ccccc2C(=O)c2oc(-c3ccccc3Cl)nc21,,C1COCCO1,,,,val
US06034275,CN1CCCC1c1ccccc1-c1ccccc1.Cl.O=C(Cl)c1ccc(Br)cc1>>CN1CCCC1c1ccc(-c2ccc(C(=O)c3ccc(Br)cc3)cc2)cc1.Cl,,S=C=S,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130072677A1,CNC(=O)C(C)(C(=O)O)N(C)C(=O)c1ccc(I)cc1.NOC1CCCCO1>>CNC(=O)C(C)(C(=O)NOC1CCCCO1)N(C)C(=O)c1ccc(I)cc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130023526A1,C=Cc1ccccc1.Cc1nc(Br)cc(C=NO)n1>>Cc1nc(Br)cc(C2=NOC(c3ccccc3)C2)n1,,ClCCl,,[Na+].[O-]Cl,,val
US20030153610A1,C[Si](C)(C)N=C=O.NCc1ccc(N2CC(CNC(=O)c3ccc(Cl)s3)OC2=O)cc1>>NC(=O)NCc1ccc(N2CC(CNC(=O)c3ccc(Cl)s3)OC2=O)cc1,,ClCCl,,CCOCC,,val
US03966801,CCNCC.O=C(O)C(O)CCc1ccc(-c2ccccc2Cl)cc1>>CC[NH2+]CC.O=C([O-])C(O)CCc1ccc(-c2ccccc2Cl)cc1,,CCCCCC,,,,val
US20060183874A1,CC(C)(Br)C(=O)Br.CC(C)c1cccc(Br)c1>>CC1Cc2cc(C(C)C)cc(Br)c2C1=O,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20120232061A1,CN(C)C=O.O=C(O)c1ccc(O)c(Br)c1>>NC(=O)c1ccc(O)c(Br)c1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US06310056B1,CC#N.CCN(C(C)C)C(C)C.C[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1C(=O)N2[C@@H](C(=O)OCc3ccc([N+](=O)[O-])cc3)C(=O)[C@H](C)[C@H]12.O=S(=O)(O)C(F)(F)F>>C[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(c3cn4cncc4s3)[C@H](C)[C@H]12,,CCOC(C)=O,,O=C([O-])O.[Na+],,val
US20140288040A1,CC[C@@H](N[S@](=O)C(C)(C)C)c1ccc(Cl)c(Oc2ncc(N)cn2)c1F.Cl>>CC[C@@H](N)c1ccc(Cl)c(Oc2ncc(N)cn2)c1F.Cl,,CCOC(C)=O,,,,val
US20090170921A1,COCCn1c(-c2ccc(C(C)C)cc2)nc2c(C#C[Si](C)(C)C)ccc(OC)c21>>C#Cc1ccc(OC)c2c1nc(-c1ccc(C(C)C)cc1)n2CCOC,,C1CCOC1,CO,[Na+].[OH-],,val
US05925662,CCOC(=O)Nc1ccc2c(c1)CCC(CC(OCc1ccccc1)C(F)(F)F)O2.COC[C@H]1COC(=O)O1>>COC[C@H]1CN(c2ccc3c(c2)CCC(CC(OCc2ccccc2)C(F)(F)F)O3)C(=O)O1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20050239926A1,O=C1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1.[Li]C>>CC1(O)O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1,,C1CCOC1,,,,val
US20040082607A1,Cc1nc(-c2ccc3c(=O)n(CC(C)C)c(CNC(=O)OC(C)(C)C)c(-c4ccccc4)c3c2)sc1C(N)=O.Cl>>Cc1nc(-c2ccc3c(=O)n(CC(C)C)c(CN)c(-c4ccccc4)c3c2)sc1C(N)=O.Cl,,CCOC(C)=O,,,,val
US20150344473A1,Nc1ncnc(Cl)c1N.O=C(O)c1ccc(CN2CCOCC2)cc1>>Clc1ncnc2[nH]c(-c3ccc(CN4CCOCC4)cc3)nc12,,O=P(Cl)(Cl)Cl,,[Cl-].[NH4+],,val
US04904658,CN(C)C=CC(=O)c1ccc(N2CCOCC2)cc1.NC(=O)c1[nH]cnc1N>>NC(=O)c1ncn2c(-c3ccc(N4CCOCC4)cc3)ccnc12,,CC(=O)O,ClCCl,Cl,O=C([O-])O.[Na+],val
US20100068419A1,CCCOc1ccc(C=CC(=O)O)cc1.OCC12C=CC(CC1)C2>>C1=CC2CCC1C2.CCCOc1ccc(C=CC(=O)[O-])c(C)c1,CN(C)c1ccncc1,,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060106089A1,COc1cc([N+](=O)[O-])ccc1S(=O)(=O)Cl.Nc1ccccc1NS(=O)(=O)c1cc2ccccc2s1>>COc1cc([N+](=O)[O-])ccc1S(=O)(=O)Nc1ccccc1NS(=O)(=O)c1cc2ccccc2s1,,ClCCl,c1ccncc1,,,val
US20150166480A1,CC(C)(C)OC(=O)N1CCC(COS(C)(=O)=O)CC1.Oc1ccc(-c2ccc3sccc3c2)cc1>>CC(C)(C)OC(=O)N1CCC(COc2ccc(-c3ccc4sccc4c3)cc2)CC1,,O,,CC#N,,val
US05112947,CC(C)(C)OC(=O)N[C@@H](COCc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)OCc1ccccc1.NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)O>>N=C(NCCC[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1)N[N+](=O)[O-],,CCOC(C)=O,Cl,C(=NC1CCCCC1)=NC1CCCCC1,On1nnc2ccccc21,val
US20100056576A1,C/C=C/c1ccc(F)c(-c2cccc(C(=O)OC)n2)c1>>CCCc1ccc(F)c(-c2cccc(C(=O)OC)n2)c1,[Pd],CO,,,,val
US06498172B1,COC(=O)CCc1cccc(CNCc2ccc(-c3ccccc3)cc2)c1.CS(=O)(=O)Cl>>COC(=O)CCc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(C)(=O)=O)c1,,CCN(CC)CC,,,,val
US20130079339A1,CCOC(C)=O.CN(C)C=O.NCc1ccc(C(F)(F)F)cc1N1CCCCC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[N-]=C=O>>O=C(NCc1ccc(C(F)(F)F)cc1N1CCCCC1)Nc1cccc2oc(=O)[nH]c12,,CCOC(C)=O,CN(C)C=O,,,val
US04347252,CC(C)(C)C1CCN(CC#Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1.O=S(=O)(O)O>>CC(C)(C)C1CCN(CC#Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1.O=S(=O)(O)O,,CCOCC,,,,val
US20100029737A1,COC(=O)c1cc2c([nH]1)C(CCc1cccc3ccccc13)CC2>>O=C(O)c1cc2c([nH]1)C(CCc1cccc3ccccc13)CC2,,C1CCOC1,,CO,[Li+].[OH-],val
US05298518,CCSc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1.O=C(OO)c1cccc(Cl)c1>>CCS(=O)(=O)c1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,,CO,ClCCl,CCOC(C)=O,O,val
US20090105275A1,CCOC(=O)C(CC(C)C)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCN(Cc3cc(F)cc(C(F)(F)F)c3)CC2)c1>>CC(C)CC(C(=O)O)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCN(Cc3cc(F)cc(C(F)(F)F)c3)CC2)c1,,CO,,[Na+].[OH-],,val
US20150231114A1,CN.O=C(O)c1csc(C2(O)CCC3(CC2)OCCO3)n1>>CNC(=O)c1csc(C2(O)CCC3(CC2)OCCO3)n1,,CCOC(C)=O,,ClCCl,,val
US20150232445A1,C[C@H]1CCc2c(OC3CCC3)cc(F)c(F)c2N1.O=C1CCC(=O)N1Br>>C[C@H]1CCc2c(c(F)c(F)c(Br)c2OC2CCC2)N1,,CC#N,ClCCl,,,val
US04092304,CC(C)(C)OC(=O)NCC(=O)Oc1cc(Cl)c(Cl)cc1Cl.CC(C)C[C@H](N)C(=O)OCc1ccccc1>>CC(C)C[C@H](NC(=O)CNC(=O)OC(C)(C)C)C(=O)OCc1ccccc1,,ClCCl,,,,val
US05523462,CCOC(=O)C1(C(=O)OCC)CC(=O)CC(=O)C1.O=C(Cl)C1CC1>>CCOC(=O)C1(C(=O)OCC)CC(=O)C=C(OC(=O)C2CC2)C1,,C1CCOC1,,CCN(CC)CC,,val
US06110960,CC(C)(O)CCOc1ccc(Br)cc1C(C)(C)C>>CC(C)(C)c1cc(Br)cc2c1OCCC2(C)C,,C[N+](=O)[O-],,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20160060197A1,CC(C)c1cccc([C@H](C)C2CC2)c1OCCl.O=P1(O)OCc2ccccc2O1>>CC(C)c1cccc([C@H](C)C2CC2)c1OCOP1(=O)OCc2ccccc2O1,,CC#N,,CCN(CC)CC,,val
US04472192,C=CCOC(=O)C(C#N)=COCC.NNc1c(Cl)cc(Br)cc1Cl>>C=CCOC(=O)c1cnn(-c2c(Cl)cc(Br)cc2Cl)c1N,,CCCCO,,,,val
US20130217668A1,CC(C)(C)OC(=O)N1CCC(C(C)(C)O)C1.Cl>>CC(C)(O)C1CCNC1.Cl,,CCOC(C)=O,ClCCl,C1COCCO1,,val
US20010007873A1,CC(C)c1cc(OCc2ccccc2)ccc1B(O)O.Cc1ccc(C)n1-c1cccc(Br)n1>>Cc1ccc(C)n1-c1cccc(-c2ccc(OCc3ccccc3)cc2C(C)C)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,O=C([O-])[O-].[Na+].[Na+],,val
US20120214803A1,CC(=O)OC(C)=O.Nc1ccccc1S(=O)(=O)Nc1cccc2cccnc12>>CC(=O)Nc1ccccc1S(=O)(=O)Nc1cccc2cccnc12,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20030119845A1,CCN(CC)C(=O)c1ccc(C(O)c2cccc3cccnc23)cc1.O=S(Cl)Cl>>CCN(CC)C(=O)c1ccc(C(Cl)c2cccc3cccnc23)cc1,,ClCCl,,,,val
US20050187236A1,CNC(=O)n1ccc2cc(Oc3ccnc(N(C(=O)Oc4ccccc4)C(=O)Oc4ccccc4)c3)ccc21.NC(=O)[C@H](N)Cc1ccccc1>>CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)N[C@H](Cc4ccccc4)C(N)=O)c3)ccc21,,CN(C)C=O,,CCN(CC)CC,Cl,val
US20100311966A1,CCO[C@@H]1CNCC[C@@H]1NC(=O)c1nc(Cl)c(CC)[nH]1.O=C(O)C(=O)Nc1ccccc1>>CCO[C@@H]1CN(C(=O)C(=O)Nc2ccccc2)CC[C@@H]1NC(=O)c1nc(Cl)c(CC)[nH]1,,CN(C)C=O,,Cl,,val
US20020042427A1,O=C1Cc2c(CCO)cccc2N1.O=Cc1[nH]cc2c1CCNC2=O>>O=C1Nc2cccc(CCO)c2C1=Cc1[nH]cc2c1CCNC2=O,,CCO,,C1CCNCC1,,val
US20100256097A1,COC(=O)c1ccc(Cl)nc1CN1CCOCC1>>OCc1ccc(Cl)nc1CN1CCOCC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],[Cl-].[NH4+],val
US20050267100A1,CC(C)N(C(=O)CN1C(=O)C(Cc2cn(C(=O)OC(C)(C)C)c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21)c1ccccc1.CI>>CC(C)N(C(=O)CN1C(=O)C(C)(Cc2cn(C(=O)OC(C)(C)C)c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21)c1ccccc1,,CCOC(C)=O,CN(C)C=O,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20080292608A1,CCOC(=O)C(Cc1ccc(OCc2nc(-c3cnc(OC(C)C)nc3)c(-c3ccc(OC(F)(F)F)cc3)o2)cc1)OCC>>CCOC(Cc1ccc(OCc2nc(-c3cnc(OC(C)C)nc3)c(-c3ccc(OC(F)(F)F)cc3)o2)cc1)C(=O)O,,O,,Cl,[Li+].[OH-],val
US05684017,O=C(Cl)c1cc(=O)c2ccccc2o1.c1ccccc1>>O=C(c1ccccc1)c1cc(=O)c2ccccc2o1,,c1ccccc1,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20080280917A1,CNCCn1nc(-c2cc(C)cs2)ccc1=O.Fc1ccnc(Cl)c1>>Cc1csc(-c2ccc(=O)n(CCN(C)c3ccnc(Cl)c3)n2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140088187A1,FC(F)(F)Oc1ccccc1Br.O=S(=O)(O)Cl>>O=S(=O)(Cl)c1ccc(OC(F)(F)F)c(Br)c1,,ClCCl,,,,val
US20150329535A1,CC(C)(C)[Si](OC[C@@H]1CC[C@@H](O)CC1)(c1ccccc1)c1ccccc1.O=C(O)CBr>>CC(C)(C)[Si](OC[C@@H]1CC[C@@H](OCC(=O)O)CC1)(c1ccccc1)c1ccccc1,,O,,[H-].[Na+],,val
US20050131012A1,Cc1ccc(SSc2ccc(C)cc2)cc1.NC(=O)c1cc2ncccc2[nH]1>>Cc1ccc(Sc2c(C(N)=O)[nH]c3cccnc23)cc1,,CN(C)C=O,,,,val
US20080004257A1,Cc1n[nH]c2ccc(-c3nncc(N4CCN(C(=O)OC(C)(C)C)[C@@H](Cc5ccccc5)C4)n3)cc12>>Cc1n[nH]c2ccc(-c3nncc(N4CCN[C@@H](Cc5ccccc5)C4)n3)cc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US05534533,COC(=O)c1ccccc1S(=O)(=O)Cl.NCCCBr>>O=C1NS(O)(O)c2ccccc21,,ClCCl,,CCN(CC)CC,Cl,val
US20150210682A1,CCOC=C(C(C)=O)C(=O)OCC.COc1cc2c(cc1OC)CC(Cc1ccccc1)N=C2>>CCOC(=O)C1=CN2C(Cc3ccccc3)Cc3cc(OC)c(OC)cc3C2CC1=O,,CCO,,,,val
US06307056B1,O=C(O)c1ccc(B(O)O)cc1.O=C1Nc2cccc(I)c2/C1=C/c1ccc[nH]1>>O=C1Nc2cccc(-c3ccc(C(=O)O)cc3)c2/C1=C/c1ccc[nH]1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20110015212A1,CCC(Br)c1cc(=O)n2c(C)cccc2n1.O=C1CCC(=O)N1I>>CCC(Br)c1nc2cccc(C)n2c(=O)c1I,,CC#N,,,,val
US20090123372A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O[C@@H]1CO[C@@H](c2ccccc2)OC1>>O=S(=O)(O[C@@H]1CO[C@@H](c2ccccc2)OC1)C(F)(F)F,,ClCCl,,,,val
US04962119,NNC(N)=S.O=C(O)c1ccccc1Nc1cccc(C(F)(F)F)c1>>NC(=S)NNC(=O)c1ccccc1Nc1cccc(C(F)(F)F)c1,,C1CCOC1,c1ccncc1,,,val
US20090197866A1,CC(C)(C)OC(=O)N1CCN(c2cc3[nH]c(-c4nn(C5CCCCO5)cc4N)nc3cc2F)CC1.O=C(Cl)N1CCCCC1>>CC(C)(C)OC(=O)N1CCN(c2cc3[nH]c(-c4nn(C5CCCCO5)cc4NC(=O)N4CCCCC4)nc3cc2F)CC1,,C1CCOC1,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20160235716A1,COc1ccc(CO)c(OC)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COc1ccc(CN=[N+]=[N-])c(OC)c1,,Cc1ccccc1,,C1CCC2=NCCCN2CC1,,val
US04999353,CCOC(=O)C(=O)N(c1ccccc1[N+](=O)[O-])C(C)(C)C>>CCOC(=O)C(=O)N(c1ccccc1N)C(C)(C)C,[Pd],CCO,,,,val
US20160222012A1,O=Cc1cc2ccc(F)cc2nc1Cl.OB(O)c1ccccc1>>O=Cc1cc2ccc(F)cc2nc1-c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,O,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],val
US20140200212A1,COC(=O)c1ccc(Cl)c([N+](=O)[O-])c1.NCCF>>COC(=O)c1ccc(NCCF)c([N+](=O)[O-])c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20120142732A1,CC(=O)Nc1cc(-c2cc(-c3ncn(COCC[Si](C)(C)C)n3)c(Br)o2)c(C)cn1.O=Cc1ccc(Cl)c(B(O)O)c1>>CC(=O)Nc1cc(-c2cc(-c3ncn(COCC[Si](C)(C)C)n3)c(-c3cc(C=O)ccc3Cl)o2)c(C)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060142333A1,CC(C)NC(C)C.O=C(CCl)N1CCCc2ccc([N+](=O)[O-])cc21>>CC(C)N(CC(=O)N1CCCc2ccc([N+](=O)[O-])cc21)C(C)C,,C1CCOC1,,,,val
US20160221972A1,COC(=O)c1ccc2c(c1)OCCN(S(=O)(=O)c1ccc(OC)cc1)C2.NO>>COc1ccc(S(=O)(=O)N2CCOc3cc(C(=O)NO)ccc3C2)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20120264734A1,C1COCCN1.CCN(c1cc(-c2ccc(C=O)nc2)cc(C(=O)NCc2c(C(C)C)cc(C)[nH]c2=O)c1C)C1CCOCC1>>CCN(c1cc(-c2ccc(CN3CCOCC3)nc2)cc(C(=O)NCc2c(C(C)C)cc(C)[nH]c2=O)c1C)C1CCOCC1,,CC(Cl)Cl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20080269293A1,Cc1cc(Oc2ccncc2N)n(-c2ccccc2)n1.O=C=Nc1ccc(OC(F)(F)F)cc1>>Cc1cc(Oc2ccncc2NC(=O)Nc2ccc(OC(F)(F)F)cc2)n(-c2ccccc2)n1,,C1CCOC1,,CCN(CC)CC,,val
US20100261702A1,CCOC(=O)CCc1c(C)cc(C(=N)NO)cc1CC.CCc1cc(C(=O)O)sc1C=O>>CCc1cc(-c2nc(-c3cc(C)c(CCC(=O)O)c(CC)c3)no2)sc1C=O,,CO,,[Na+].[OH-],,val
US20080221096A1,C1COCCN1.CC1(C)CCc2c(O)nc3oc4c(NCc5cccnc5)ncnc4c3c2C1>>CC1(C)CCc2c(N3CCOCC3)nc3oc4c(NCc5cccnc5)ncnc4c3c2C1,,CN(C)C=O,,[H-].[Na+],,val
US20040006099A1,N=C(N)N1CCc2ccc(OCC3(C(=O)O)CCN(c4ccncc4)CC3)cc2C1>>N=C(N)N1CCc2ccc(OCC3(C(=O)O)CCN(c4ccncc4)CC3)cc2C1,,O,,Cl,Cl,val
US04587049,C=[N+]=[N-].CC[C@@H]1C(=O)N(Cc2ccc(OC)cc2OC)[C@H]1C(=O)O>>CC[C@@H]1C(=O)N(Cc2ccc(OC)cc2OC)[C@H]1C(=O)C=[N+]=[N-],,CCOCC,,C1CCOC1,CCN(CC)CC,val
US20100152160A1,CC(C)(C)OC(=O)N1CC(C(=O)N2CCC(C#N)(Cc3ccc(F)cc3)CC2)Oc2cc(O)c(Cl)cc21.CCI>>CCOc1cc2c(cc1Cl)N(C(=O)OC(C)(C)C)CC(C(=O)N1CCC(C#N)(Cc3ccc(F)cc3)CC1)O2,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06075037,CCOC(=O)c1[nH]c2ncccc2c1-c1ccc(OC)cc1.ClCc1ccc2c(c1)OCO2>>CCOC(=O)c1c(-c2ccc(OC)cc2)c2cccnc2n1Cc1ccc2c(c1)OCO2,,CN(C)P(=O)(N(C)C)N(C)C,,[H-].[Na+],,val
US20040133008A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=[N+]([O-])c1ccc(NCCn2nccc2NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N(CCn1nccc1NC(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccc([N+](=O)[O-])cc1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20030199547A1,CCOC(=O)c1c(-c2cccc(Cl)c2)c2cc(C(O)c3nc(-c4ccccc4)cs3)ccc2[nH]c1=O.O=S(Cl)Cl>>CCOC(=O)c1c(-c2cccc(Cl)c2)c2cc(C(Cl)c3nc(-c4ccccc4)cs3)ccc2[nH]c1=O,,ClCCl,,,,val
US20120149691A1,N#Cc1cnn2cccc2c1Cl.NC1CCCOC1>>N#Cc1cnn2cccc2c1NC1CCCOC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20060194809A1,CCc1ccc(C(O)c2cnccc2Cl)cc1>>CCc1ccc(C(=O)c2cnccc2Cl)cc1,,ClC(Cl)Cl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US04820703,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C1CN=C(c2ccccc2Cl)c2cc(CCc3ccc(Cl)cc3)sc2N1>>S=C1CN=C(c2ccccc2Cl)c2cc(CCc3ccc(Cl)cc3)sc2N1,,Cc1ccccc1,,,,val
US20100331295A1,CC(=O)c1ccc(-c2cccc(S(C)(=O)=O)c2)s1.CCOC(=O)C(F)(F)F>>CS(=O)(=O)c1cccc(-c2ccc(C(=O)CC(=O)C(F)(F)F)s2)c1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20150181867A1,CCCO[C@@H](CCC[C@H](NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1)[C@@H](CCC(C)C)[C@H](C)O>>CCCO[C@@H](CCC[C@H](NC(=O)OC(C)(C)C)C(=O)O)[C@@H](CCC(C)C)[C@H](C)O,[Pd],C1CCOC1,,,,val
US20100298287A1,OCc1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl>>O=Cc1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl,,ClCCl,,CCN(CC)CC,CS(C)=O,val
US20150239908A1,C[C@H]1C[C@H]2CSC(NC(=O)c3ccccc3)=N[C@@]2(c2ccc(F)cc2F)CO1>>C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2ccc(F)cc2F)CO1,,CO,,C1CCC2=NCCCN2CC1,,val
US20110224155A1,CO.NC1=NS(=O)(=O)Nc2cccc(OC[C@H]3OC(O)[C@H](O)[C@@H]3O)c21>>COC1O[C@H](COc2cccc3c2C(N)=NS(=O)(=O)N3)[C@@H](O)[C@H]1O,,CO,,O=C(O)C(F)(F)F,,val
US20030166644A1,COc1ccc(NC(=O)CCCC(=O)Cl)cn1.O=S(Cl)Cl>>COc1ccc(N2C(=O)CCCC2=O)cn1.Cl,,ClCCl,,,,val
US20090149425A1,BrC(Br)(Br)Br.CCC(O)c1cc(C(F)(F)F)on1>>CCC(Br)c1cc(C(F)(F)F)on1,,CCOCC,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20070249603A1,CN(C)C1CCN(c2cccc3cc(S(=O)(=O)c4ccccc4)cnc23)CC1.Cl.O=C1CCC(=O)N1I>>CN(C)C1CCN(c2ccc(I)c3cc(S(=O)(=O)c4ccccc4)cnc23)CC1.Cl,,CC(=O)O,CCOC(C)=O,,,val
US06225311B1,CC#CCOc1ccc(S(=O)(=O)NC(C(=O)OC)c2ccccc2O[Si](C)(C)C(C)(C)C)cc1.CI>>CC#CCOc1ccc(S(=O)(=O)N(C)CC(=O)OC)cc1,,CN(C)C=O,O,[H-].[Na+],,val
US20140081017A1,O=C(O)c1ccc(CCCCc2ccccc2)o1.O=S(Cl)Cl>>O=C(Cl)c1ccc(CCCCc2ccccc2)o1,,Cc1ccccc1,,,,val
US20050020652A1,CCOC(=O)C(C)(C)Oc1ccc(OCCC2CN(Cc3ccc(OC)cc3)C(=O)N2C)cc1C>>CCOC(=O)C(C)(C)Oc1ccc(OCCC2CNC(=O)N2C)cc1C,,O=C(O)C(F)(F)F,,,,val
US20150376173A1,CC(=O)OC(C)=O.CC(C)CCON=O.COC(=O)c1ccc(N)c(C)c1>>CC(=O)c1n[nH]c2ccccc12,,ClC(Cl)Cl,ClCCl,CC(=O)[O-].[K+],,val
US20160159793A1,CC(C)O.CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C(=O)O)n2c1COCC2)c1ccccc1>>CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C(=O)OC(C)C)n2c1COCC2)c1ccccc1,Cl,,,,,val
US20110112065A1,C=CCN.CS(=O)(=O)c1cc(F)c2c(c1)OC(CBr)OC2>>C=CCNCC1OCc2c(F)cc(S(C)(=O)=O)cc2O1,,CCO,,,,val
US20060258685A1,COC(=O)C(C(C)=O)c1c(F)cc(F)cc1F.Nc1cc[nH]n1>>Cc1nc2ccnn2c(O)c1-c1c(F)cc(F)cc1F,,CO,,CCCCN(CCCC)CCCC,,val
US20090137798A1,CCCC(CCC)CCCC1COCCN1CCO.Cl>>CCCC(CCC)CCCC1COCCN1CCO.Cl,,CC(=O)CC(C)C,,,,val
US20150291655A1,C=C(C)[C@@H]1CC[C@]2(NCCN3CCC(C(=O)OCC)(C(=O)OCC)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@@](CF)(C(=O)O[Si](C)(C)C(C)(C)C)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12>>C=C(C)[C@@H]1CC[C@]2(NCCN3CCC(C(=O)OCC)(C(=O)OCC)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@@](CF)(C(=O)O)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05149357,COc1cc(OC)nc(Sc2cccc(Cl)c2C(=O)O)n1.O=[N+]([O-])c1ccc(O)cc1>>COc1cc(OC)nc(Sc2cccc(Cl)c2C(=O)Oc2ccc([N+](=O)[O-])cc2)n1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20060135578A1,CCOP(=O)(CP(=O)(OCC)OCC)OCC.COc1cc(COc2nn(C)cc2C=O)ccc1OCc1nc(-c2ccco2)oc1C>>CCOP(=O)(/C=C/c1cn(C)nc1OCc1ccc(OCc2nc(-c3ccco3)oc2C)c(OC)c1)OCC,,O,,CN(C)C=O,[H-].[Na+],val
US05276025,CC(C)CBr.CC1CNCc2cc(S(N)(=O)=O)sc2S1(=O)=O>>CC(C)CN1Cc2cc(S(N)(=O)=O)sc2S(=O)(=O)C(C)C1,,CN(C)C=O,,CCN(CC)CC,O,val
US20160130253A1,Brc1cc(-c2ccncc2)c(-c2ccc3ccccc3c2)nn1.C1CCNCC1>>c1ccc2cc(-c3nnc(N4CCCCC4)cc3-c3ccncc3)ccc2c1,,CCO,,,,val
US20160159773A1,CC(C)(C)OC(=O)N1CC=C(c2ccc([N+](=O)[O-])nc2)CC1.Cl>>Cl.O=[N+]([O-])c1ccc(C2=CCNCC2)cn1,,CO,,CCOC(C)=O,,val
US20160264585A1,Cc1cc(C)n2nc(CO)nc2n1.O=S(Cl)Cl>>Cc1cc(C)n2nc(CCl)nc2n1,,ClCCl,O,c1ccncc1,,val
US20090239854A1,C=Cc1cnc2c(ccn2C)c1.CN1CCc2[nH]c3ccc(Cl)cc3c2C1>>CN1CCc2c(c3cc(Cl)ccc3n2CCc2cnc3c(ccn3C)c2)C1,,CN1CCCC1=O,,[K+].[OH-],,val
US20090062223A1,CC(C)(C)[SiH2]OC(C)(C)C1OC(n2cc3c(N)cc4c(=O)[nH]ncc(n2)c34)C(C)(O)C1OC(=O)CCN1CCOCC1>>CC1(O)C(OC(=O)CCN2CCOCC2)C(CO)OC1n1cc2c(N)cc3c(=O)[nH]ncc(n1)c23,,C1CCOC1,,,,val
US20120309764A1,COCCn1nc(-c2ccccc2)nc1CO>>COCCn1nc(-c2ccccc2)nc1C=O,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20120165305A1,CC(C)(C)OC(=O)N1CCC(n2cc(-c3cnn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CC1>>O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cnn(C5CCNCC5)c4)cnn23)c1,,C1COCCO1,CO,Cl,C[O-].[Na+],val
US20120329649A1,CC(C)(C)OC(=O)NCC(=O)O.O=[N+]([O-])c1ccc(O)cc1>>CC(C)(C)OC(=O)NCC(=O)Oc1ccc([N+](=O)[O-])cc1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20090298809A1,BrCc1ccccc1.COC(=O)c1cccc2[nH]ccc12>>COC(=O)c1cccc2c1ccn2Cc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20150166512A1,CCOC(=O)c1c(-c2cc(Cl)ccc2C)cc(-c2cc(N)ncn2)n1S(=O)(=O)c1ccccc1>>Cc1ccc(Cl)cc1-c1cc(-c2cc(N)ncn2)[nH]c1C(=O)O,,C1CCOC1,,O,[Li]O,val
US20150166521A1,CC(C)(C)[Si](C)(C)OCCCSCCCO[Si](C)(C)C(C)(C)C.CO>>CC(C)(C)[Si](C)(C)OCCCS(=O)CCCO[Si](C)(C)C(C)(C)C,,CO,O,[Na+].[O-][I+3]([O-])([O-])[O-],,val
US20080306053A1,Cc1cccc(Br)c1N.N#C[Cu]>>Cc1cccc(C#N)c1N,,CN1CCCC1=O,,N,,val
US20020016328A1,CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C=O.[Li]C>>CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C(C)O,,C1CCOC1,,[Li],,val
US20070254867A1,Brc1cccnc1.COc1cc(Cl)ccc1C=O>>COc1cc(Cl)ccc1C(O)c1cccnc1,,Cc1ccccc1,,C1CCOC1,[Li]CCCC,val
US20090005560A1,NCc1ccccc1.O=C(Cc1ccccc1)Nc1cnc(-c2ccccc2)nc1Cl>>Cl.O=C(Cc1ccccc1)Nc1cnc(-c2ccccc2)nc1NCc1ccccc1,,CC(C)O,,CCN(CC)CC,,val
US20150232481A1,C=CCC(C)OC(=O)c1ccc(Cl)cc1O[C@@H](C)CC=C>>C=CC[C@H](C)Oc1cc(Cl)ccc1CO,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20060116410A1,COC(=O)c1cc(O)cc(Cl)c1.COCCBr>>COCCOc1cc(Cl)cc(C(=O)OC)c1,,CC(=O)N(C)C,,[H-].[Na+],,val
US06365736B1,CC1Oc2ccc(C=C[N+](=O)[O-])cc2NC1=O>>CC1Oc2ccc(CCN)cc2NC1=O,O=[Pt]=O,CC(=O)O,,O=S(=O)(O)O,,val
US20060148858A1,CCOC(=O)CCc1ccc(OC)cc1O.CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO>>CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1cc(OC)ccc1CCC(=O)O,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US04161528,Cc1ccc(NCCNc2cccc(Cl)c2)cc1.O=CC(Cl)(Cl)Cl>>Cc1ccc(N2CCN(c3cccc(Cl)c3)C2C(Cl)(Cl)Cl)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05750531,Cc1cc(N2CCc3ccccc3C2C)nc(Cl)n1.Nc1ccc(F)cc1>>Cc1cc(N2CCc3ccccc3C2C)nc(Nc2ccc(F)cc2)n1.Cl,,CN(C)C=O,,,,val
US20090275570A1,CC(C)(C)OC(=O)N1CCC[C@H](Nc2ncc(C#N)c3sc(-c4ccc(N5CCNCC5)cc4)cc23)C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCC[C@H](Nc2ncc(C#N)c3sc(-c4ccc(N5CCN(S(C)(=O)=O)CC5)cc4)cc23)C1,,C1CCOC1,,,,val
US20040127492A1,BrBr.COC(=O)c1[nH]nc2c1CCc1cc(OC)ccc1-2>>COC(=O)c1[nH]nc2c1CCc1cc(OC)c(Br)cc1-2,,CC(=O)O,,CC(=O)[O-].[Na+],,val
US20070232612A1,CN1C[C@@H]2NCC[C@@H]2C1.O=C(c1ccccc1)c1ccc(F)cc1>>CN1C[C@H]2[C@H](CCN2c2ccc(C(=O)c3ccccc3)cc2)C1,,CC#N,O,CCN(CC)CC,,val
US20150368245A1,CI.CN(C)C=O.O=C(O)[C@@H]1CC[C@@H](C(=O)O)CC1>>COC(=O)[C@@H]1CC[C@@H](C(=O)OC)CC1,,O,,CCOCC,O=C([O-])[O-].[K+].[K+],val
US05232922,Cn1cnc(S(=O)(=O)NCCCN2CCOCC2)c1Cl>>Cn1cnc(S(=O)(=O)NCCCN2CCOCC2)c1,[Pd],O,,Cl,,val
US20030060466A1,COc1ccccc1N1CCNCC1.N#Cc1c(Cl)nc(NCCO)nc1NCCO>>COc1ccccc1N1CCN(c2nc(NCCO)nc(NCCO)c2C#N)CC1,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US04219657,C=[N+]=[N-].Cc1ccc2sc3cc(C(=O)Cl)ccc3c2c1>>Cc1ccc2sc3cc(C(=O)C=[N+]=[N-])ccc3c2c1,,CCOCC,,,,val
US04607030,COc1ccc(C(C)(C)C)cc1.O=S(=O)(O)Cl>>COc1ccc(C(C)(C)C)cc1S(=O)(=O)Cl,,ClCCl,,,,val
US20120122840A1,CCN1CCC(CO)CC1.Cc1cc(F)ccc1[N+](=O)[O-]>>CCN1CCC(COc2ccc(N)c(C)c2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20120046306A1,O=C1Cc2ncccc2N1.O=Cc1cccc(Cl)c1F>>O=C1Nc2cccnc2/C1=C/c1cccc(Cl)c1F,,CO,,C1CCNCC1,,val
US20080234237A1,CN1CCC(N2CCCCc3ccccc32)CC1.O=C1CCC(=O)N1Br>>CN1CCC(N2CCCCc3cc(Br)ccc32)CC1,,CN(C)C=O,O,,,val
US20160046631A1,CC(=O)N[C@H]1CCNC1.CC(C)(C)c1nc(Cl)c2nc[nH]c2n1>>CC(=O)N[C@H]1CCN(c2nc(C(C)(C)C)nc3[nH]cnc23)C1,,CCO,,CCN(C(C)C)C(C)C,,val
US20050267093A1,CC1CNCC(C)C1.COc1cc([N+](=O)[O-])ccc1OCCBr>>COc1cc([N+](=O)[O-])ccc1OCCN1CC(C)CC(C)C1,,CO,ClCCl,,,val
US20020147230A1,CCOc1c(OCC)c(=O)c1=O.Nc1cccnc1>>CCOc1c(Nc2cccnc2)c(=O)c1=O,,CCO,,,,val
US20110015175A1,COc1cc(N=C=S)ccc1-c1nc(C)no1.N>>COc1cc(NC(N)=S)ccc1-c1nc(C)no1,,CO,,,,val
US20090181956A1,Cc1cc(Cl)cc2c(=O)oc(-c3cc(C(F)(F)F)nn3-c3ccccc3Cl)nc12.NN>>Cc1cc(Cl)cc(C(=O)NN)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ccccc1Cl,,O,,C1CCOC1,,val
US20030229094A1,O=C(CCl)Nc1ccccc1.c1ccc(N2CCNCC2)nc1>>O=C(CN1CCN(c2ccccn2)CC1)Nc1ccccc1,,Cc1ccccc1,,CCN(C(C)C)C(C)C,,val
US20140349990A1,Cc1cc(NC(c2ccc(Cl)cc2)c2cn(C)nc2C(=O)O)cn(C)c1=O>>Cc1cc(N2C(=O)c3nn(C)cc3C2c2ccc(Cl)cc2)cn(C)c1=O,,CO,ClCCl,,,val
US20160184305A1,CCOc1cc(N)c(N)cc1Br.O=CC=O>>CCOc1cc2nccnc2cc1Br,,C1CCOC1,,,,val
US20110052578A1,C[C@@H](CNc1ccnc(-c2c(Br)nc(-c3ccc(C(F)(F)F)cc3)n2COCC[Si](C)(C)C)n1)NC(=O)OC(C)(C)C>>C[C@H](N)CNc1ccnc(-c2[nH]c(-c3ccc(C(F)(F)F)cc3)nc2Br)n1,,CO,Cl,,,val
US20040110787A1,CCOC(=O)c1cn(C)c2sc(CN(C)C[C@@H](O)c3ccccn3)cc2c1=O.N#Cc1ccc(CN)cc1>>CN(Cc1cc2c(=O)c(C(=O)NCc3ccc(C#N)cc3)cn(C)c2s1)C[C@@H](O)c1ccccn1,,CO,,C[O-].[Na+],,val
US20070287724A1,CC(C)(C)OC(=O)N1CCC(O)(CN)CC1.O=[N+]([O-])c1cnc2ncccc2c1Cl>>CC(C)(C)OC(=O)N1CCC(O)(CNc2c([N+](=O)[O-])cnc3cccnc23)CC1,,O=C([O-])O,[Na+],CCN(CC)CC,ClCCl,val
US04374843,C1CCOC1.CCOC(CBr)(OCC)C(=O)CBr.N=C(N)NC(N)=S>>C.CCOC(CBr)(OCC)c1csc(NC(=N)N)n1,,C1CCOC1,,,,val
US20120101127A1,C=C(C)C.Nc1ccc(Cl)cc1.O=Cc1cccc(Br)c1>>CC1(C)CC(c2cccc(Br)c2)Nc2ccc(Cl)cc21,,CC#N,CCOC(C)=O,O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3],,val
US20140057914A1,CC(NC(=O)c1nc(-c2ccc(OC(F)(F)F)cc2)no1)C(O)Cc1cccc(Br)c1>>CC(NC(=O)c1nc(-c2ccc(OC(F)(F)F)cc2)no1)C(=O)Cc1cccc(Br)c1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US04868321,CCS(=O)(=O)Nc1cc(N)c(F)cc1Cl.S=C(Cl)Cl>>CCS(=O)(=O)Nc1cc(N=C=S)c(F)cc1Cl,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20150087585A1,O=Cc1cccc(C=O)n1.OCCO>>O=Cc1cccc(C2OCCO2)n1,,c1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090012311A1,COC(=O)Cl.Nc1ccc(Br)c(F)c1>>COC(=O)Nc1ccc(Br)c(F)c1,,ClCCl,O,O=C([O-])O.[Na+],,val
US04752645,C=CCBr.COC(=O)C(C(=O)OC)C(Cc1cc(C(F)(F)F)ccc1[N+](=O)[O-])c1ccc(OC)cc1>>C=CCC(C(=O)OC)(C(=O)OC)C(Cc1cc(C(F)(F)F)ccc1[N+](=O)[O-])c1ccc(OC)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100093803A1,CS(=O)(=O)c1ccc(S(C)(=O)=O)nc1.NN>>CS(=O)(=O)c1ccc(NN)nc1,,CCO,,O,,val
US20140221361A1,CC1([C@@H]2CC[C@]3(N)CC[C@]4(C)[C@H](CC[C@@H]5[C@@]6(C)CC=C(c7ccc(C(=O)O)cc7)C(C)(C)[C@@H]6CC[C@]54C)[C@@H]23)CC1>>CC1([C@@H]2CC[C@]3(N)CC[C@]4(C)[C@H](CC[C@@H]5[C@@]6(C)CC[C@H](c7ccc(C(=O)O)cc7)C(C)(C)[C@@H]6CC[C@]54C)[C@@H]23)CC1,[Pd],CCOC(C)=O,,[H][H],,val
US20030105142A1,Cc1ccc(NC(=O)c2cccc(N3CCOCC3)c2)cc1N.O=C(Cl)c1cccs1>>Cc1ccc(NC(=O)c2cccc(N3CCOCC3)c2)cc1NC(=O)c1cccs1,,ClCCl,,CCN(CC)CC,,val
US06576596B1,COC(=O)c1ccc(Cl)c(CBr)c1Cl.O>>COC(=O)c1ccc(Cl)c(C=O)c1Cl,,CC#N,,C[N+]1([O-])CCOCC1,,val
US20150080393A1,CCOC(=O)[C@@H]1CC2(CCNCC2)CN1C(=O)OCc1ccccc1.Cc1ccn(-c2cc(Br)ccc2[C@@H](Oc2cc(Cl)nc(N)n2)C(F)(F)F)n1>>CCOC(=O)[C@@H]1CC2(CCN(c3cc(O[C@H](c4ccc(Br)cc4-n4ccc(C)n4)C(F)(F)F)nc(N)n3)CC2)CN1C(=O)OCc1ccccc1,,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US06075148,CCC(=O)N(O)c1ccccc1C.CI>>CCC(=O)N(OC)c1ccccc1C,,CN(C)C=O,O,[H-].[Na+],,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2CC.CSCCBr>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCSC)cc1CC2CC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100035874A1,CCCNCC1CC1.CCc1nn2c(-c3ccc(Cl)cc3Cl)c(C)oc2c1C(=O)O>>CCCN(CC1CC1)C(=O)c1c(CC)nn2c(-c3ccc(Cl)cc3Cl)c(C)oc12,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070249680A1,N#CC1(c2ccc([N+](=O)[O-])cc2)CCS(=O)(=O)CC1.O>>NC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCS(=O)(=O)CC1,,CCO,CCOC(C)=O,,,val
US20070142372A1,CC(C)(C)OC(=O)NN=C(c1ccc(Br)cc1F)C1CCOC1>>Brc1ccc2c(C3CCOC3)n[nH]c2c1,,C1CCOC1,,C1CCC2=NCCCN2CC1,,val
US04895867,CC(C)c1ccc(N)cc1.O=Cc1ccco1>>CC(C)c1ccc(-c2ccc(C=O)o2)cc1,,CC#N,O,Cl,O=N[O-].[Na+],val
US20040209865A1,C1CCNC1.CC(Cl)C(=O)Nc1ccc(Br)cn1>>CC(C(=O)Nc1ccc(Br)cn1)N1CCCC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US05608056,C=CCOC(=O)N1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CC(N)=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>C=CCOC(=O)N1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@@H]1CC(N)=S,,COCCOC,O,CCOC(C)=O,O=C([O-])O.[Na+],val
US06294555B1,CC(C)(C)OC(=O)NC1CCN(CC2CCN(C(=O)OCc3ccccc3)CC2)CC1>>NC1CCN(CC2CCN(C(=O)OCc3ccccc3)CC2)CC1,,CCO,,Cl,,val
US20120295294A1,COC(=O)[C@@H](N)Cc1ccccc1.N[C@@H](CC(=O)O)C(=O)O>>COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O,,CO,,,,val
US03976635,CCOC(=O)C(C#N)=NO.O=C(Cl)Oc1ccccc1>>CCOC(=O)C(C#N)=NOC(=O)Oc1ccccc1,,c1ccccc1,,CCN(CC)CC,,val
US20090076004A1,CCOC(=O)Cc1c(C(=O)OCC)c2cc(OS(=O)(=O)C(F)(F)F)ccc2n1-c1ccc(C(C)C)cc1.OB(O)c1ccc(C(F)(F)F)cc1>>CCOC(=O)Cc1c(C(=O)OCC)c2cc(-c3ccc(C(F)(F)F)cc3)ccc2n1-c1ccc(C(C)C)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US04017298,CC(C(=O)C1CCCCC1)C(=O)C1CCCCC1.CNN>>Cc1c(C2CCCCC2)nn(C)c1C1CCCCC1,,O,,CC(C)O,,val
US20020173653A1,CC(C)Cn1cnc2c(N)nc3cnccc3c21>>CC(C)Cn1cnc2c(N)nc3c(c21)CCNC3,O=[Pt],O=C(O)C(F)(F)F,,[H][H],,val
US05200111,CC(=O)OC(C)=O.C[C@H](O)C[C@@H](C)Oc1ccc(-c2ccc(C#N)cc2)cc1>>CC(=O)O[C@@H](C)C[C@@H](C)Oc1ccc(-c2ccc(C#N)cc2)cc1,,c1ccncc1,,Cl,,val
US20100210619A1,O=C(OC1CCCCC1)c1cc(OC2CCCCC2)nc(Cl)n1.O=C[O-].[NH4+]>>O=C(OC1CCCCC1)c1cc(OC2CCCCC2)ncn1.O=C[O-].[NH4+],[Pd],O,,,,val
US20100292225A1,CC1(C)OB(c2cncc(C=O)c2)OC1(C)C.Cn1c(I)nc2ccc(Cl)cc21>>Cn1c(-c2cncc(C=O)c2)nc2ccc(Cl)cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20150329538A1,CC(=O)OC(C)=O.Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H]1CC[C@@H]1N>>CC(=O)N[C@@H]1CC[C@@H]1Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20120172345A1,N#Cc1sc(N2CCOCC2)nc1Cc1ccc2ccccc2c1.[N-]=[N+]=[N-].[NH4+]>>c1ccc2cc(Cc3nc(N4CCOCC4)sc3-c3nnn[nH]3)ccc2c1,,CCOC(C)=O,CN(C)C=O,O,[Cl-].[Na+],val
US20150133512A1,C[C@@H](O)c1ccccc1.Cc1nnn(-c2ccc(Br)cc2)c1C(=O)O.[N-]=[N+]=NP(=O)(Oc1ccccc1)Oc1ccccc1>>Cc1nnn(-c2ccc(Br)cc2)c1NC(=O)O[C@H](C)c1ccccc1,,Cc1ccccc1,,CCN(CC)CC,,val
US04022908,BrBr.COc1ccc2c(-c3ccccc3)coc2c1>>COc1ccc2c(-c3ccccc3)c(Br)oc2c1,,ClCCl,,,,val
US03943127,CC(Sc1nnn[nH]1)C1=C(C(=O)OC(C)(C)C)N2C(=O)C(NC(=O)CS(=O)C(F)(F)F)[C@H]2SC1>>CC(Sc1nnn[nH]1)C1=C(C(=O)O)N2C(=O)C(NC(=O)CS(=O)C(F)(F)F)[C@H]2SC1,,O=C(O)C(F)(F)F,,CCOCC,,val
US20130261106A1,CC(C)Oc1cc(F)ccc1[N+](=O)[O-].CO>>COc1ccc([N+](=O)[O-])c(OC(C)C)c1,,CO,,C[O-].[Na+],,val
US20070027318A1,COc1cc2ncnc(Oc3ccc(N)cc3C)c2cc1OC.O=C=Nc1ccc(F)cc1>>COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3C)c2cc1OC,,ClC(Cl)Cl,,,,val
US20080051395A1,CSc1nccc(Cl)n1.I>>CSc1nccc(I)n1,,CCCCCC,,,,val
US05447954,COC(=O)C1(O)CC(=O)OC1CCCCCCCCc1ccc(Cl)cc1Cl>>O=C1C[C@](O)(C(=O)O)[C@@H](CCCCCCCCc2ccc(Cl)cc2Cl)O1,,CO,O,[Na+].[OH-],,val
US07189754B2,CC(C)(C)OC(=O)N1CC(=O)C[C@H]1C(=O)O.CCON>>CCON=C1CC(C(=O)O)N(C(=O)OC(C)(C)C)C1,,CCO,,Cl,c1ccncc1,val
US20050176786A1,N#CCC(=O)c1ccccc1Br.NN>>Nc1cc(-c2ccccc2Br)n[nH]1,,CCO,,O,,val
US20040110773A1,COc1ccc(N2C(=O)N(c3cccc(C#N)c3)c3nc(Nc4cccc(CCO)c4)ncc3C2C)cc1.CS(=O)(=O)Cl>>COc1ccc(N2C(=O)N(c3cccc(C#N)c3)c3nc(Nc4cccc(CCOS(C)(=O)=O)c4)ncc3C2C)cc1,,ClCCl,,CCN(CC)CC,,val
US20100222299A1,CC(C)[Si](Cl)(C(C)C)C(C)C.COc1cc2c(cc1O)CC(C)(C)NC2>>COc1cc2c(cc1O[Si](C(C)C)(C(C)C)C(C)C)CC(C)(C)NC2,,ClC(Cl)Cl,ClCCl,O,c1c[nH]cn1,val
US20110098324A1,CC1(C)OC(=O)c2c(cc(Cl)oc2=O)O1.CC1(C)OC(=O)c2c(cc(NCc3ccc(C(F)(F)F)cc3F)oc2=O)O1.CCN(C(C)C)C(C)C.NCc1ccc(C(F)(F)F)cc1F>>O=C(O)CNC(=O)c1c(O)c(C(=O)NCc2ccc(C(F)(F)F)cc2F)c(O)n(Cc2ccc(C(F)(F)F)cc2F)c1=O,,ClC(Cl)Cl,,CO,,val
US05604229,C=CCCCBr.CCOC(=O)C(NC(C)=O)C(=O)OCC>>CCCC=CC(NC(C)=O)(C(=O)OCC)C(=O)OCC,,CCO,,C,C[O-].[Na+],val
US04338333,COC(=O)C=CCOc1ccc(CC(C)=O)cc1>>COC(=O)CCCOc1ccc(CC(C)=O)cc1,[Pd],CCO,,[H][H],,val
US20110021537A1,O=C(O)CNC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1.O=C(OC1CCC1)N1CCNCC1>>O=C(NCC(=O)N1CCN(C(=O)OC2CCC2)CC1)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140065103A1,COC(=O)c1sc(Br)cc1NC(C)C.C[C@@H]1CC[C@@H](C(=O)Cl)CC1>>COC(=O)c1sc(Br)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C(C)C,,CCOC(C)=O,Cc1ccccc1,c1ccncc1,,val
US20030040513A1,CC(C)C(=O)Cl.Nc1ccc(N2CCC(N3C(=O)OCc4ccccc43)CC2)c(Cl)c1>>CC(C)C(=O)Nc1ccc(N2CCC(N3C(=O)OCc4ccccc43)CC2)c(Cl)c1,,ClCCl,,CCN(CC)CC,,val
US20160083376A1,CCOC(=O)c1c(O)c(-c2cccc([N+](=O)[O-])c2)nn(C)c1=O.O=C(Cl)C(=O)Cl>>CCOC(=O)c1c(Cl)c(-c2cccc([N+](=O)[O-])c2)nn(C)c1=O,,ClCCl,,CN(C)C=O,,val
US20070066632A1,CNC(=O)c1cnccc1Nc1nc(-c2cc(Cl)ccc2F)nc2nc(N(Cc3ccc(OC)cc3)Cc3ccc(OC)cc3)ccc12>>CNC(=O)c1cnccc1Nc1nc(-c2cc(Cl)ccc2F)nc2nc(N)ccc12,,O=C(O)C(F)(F)F,,,,val
US20080021059A1,CCN=C=O.CN(C)C1CCN(c2cc(-c3cccnc3)cc3nc(N)nn23)C1>>CCNC(=O)Nc1nc2cc(-c3cccnc3)cc(N3CCC(N(C)C)C3)n2n1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
USRE030495,CC(C)(C)c1csc(C(=O)[O-])c1Cl.CC(C)=O.CCN(CC)CC.CN(C)C(=O)Nc1cccc(N)c1>>CCCCNC(=S)c1cccc(NC(=O)N(C)C)c1,,O,,,,val
US04474814,O=C(Cl)c1ccc([N+](=O)[O-])cc1.S=C1NCCS1>>O=C(c1ccc([N+](=O)[O-])cc1)N1CCSC1=S,,CCN(CC)CC,,C1CCOC1,,val
US20150307479A1,CNc1ccccc1N.O=C1CC(C(=O)O)C1>>Cn1c(C2CC(=O)C2)nc2ccccc21,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04323575,CC(C)(N)CN.O=C(O)[C@@H]1CCCN1C(=O)Cc1ccccc1>>CC(C)(N)CN1CCC[C@H]1C(=O)NC(=O)Cc1ccccc1,,ClC(Cl)Cl,O,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20110105544A1,COC(=O)C(CCCc1ccccc1)CCc1ccc(OS(=O)(=O)C(F)(F)F)cc1.OB(O)c1ccccc1>>COC(=O)C(CCCc1ccccc1)CCc1ccc(-c2ccccc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110112122A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Clc1cc(Br)cc2c3c([nH]c12)CC1CCC3N1>>CC(C)(C)OC(=O)c1c(Br)cc(Cl)c2[nH]c3c(c12)C1CCC(C3)N1,,CC(C)O,O,O=C([O-])[O-].[K+].[K+],,val
US20160046618A1,OCC1CC1.Oc1cnc2c(Cl)nccc2c1>>Clc1nccc2cc(OCC3CC3)cnc12,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100256143A1,Clc1cc(N2CCOCC2)nc(CBr)n1.c1ccc2c(c1)CCNC2>>Clc1cc(N2CCOCC2)nc(CN2CCc3ccccc3C2)n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100222396A1,CN(C(=O)OC(C)(C)C)[C@H](CCNC(=O)c1ccccn1)Cc1ccccc1.Cl>>CN[C@H](CCNC(=O)c1ccccn1)Cc1ccccc1.Cl,,ClCCl,,C1COCCO1,,val
US05747498,COc1cc2ncnc(Cl)c2cc1OC.Nc1cc(N)cc(Cl)c1>>COc1cc2ncnc(Nc3cc(N)cc(Cl)c3)c2cc1OC.Cl,,CC(C)O,CO,,,val
US20090181928A1,CC(C)(C)OC(=O)/C=C/c1ccc(N2CC(=O)NS2(=O)=O)c(OCc2ccccc2)c1>>O=C(O)/C=C/c1ccc(N2CC(=O)NS2(=O)=O)c(OCc2ccccc2)c1,,C1CCOC1,,CO,[Na+].[OH-],val
US20110172297A1,O=C(O)[C@@H]1CCOC[C@H]1c1ccc(I)cc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>N[C@@H]1CCOC[C@H]1c1ccc(I)cc1,,C1CCOC1,Cc1ccccc1,CCN(C(C)C)C(C)C,[Na+].[OH-],val
US20050137398A1,Cl.Nc1ccc(Oc2ccc(NC3CN4CCC3CC4)cc2)cc1>>Cl.Nc1ccc(Oc2ccc(NC3CN4CCC3CC4)cc2)cc1,,C1COCCO1,CCOC(C)=O,,,val
US20060063775A1,O=C=NC(c1ccccc1)c1ccccc1.c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>O=C(NC(c1ccccc1)c1ccccc1)N1CCN(C(c2ccccc2)c2ccccc2)CC1,,ClCCl,,,,val
US20120264906A1,CCCCCCOc1cc2c(CC)c(Br)ccc2c(CC)c1Br.CCOC(CSSCC(OCC)OCC)OCC>>CCCCCCOc1cc2c(CC)c(SCC(OCC)OCC)ccc2c(CC)c1SCC(OCC)OCC,,C1CCOC1,,[Li]CCCC,,val
US20150284401A1,CCOC(C)=O.CO.NC(c1ccccc1)C(N)c1ccccc1>>O=C1NC(c2ccccc2)C(c2ccccc2)NC1=O,,CO,,Cc1ccccc1,,val
US05608056,C=CCOC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]1Cc1cncnc1>>C=CCOC(=O)N1C[C@H](O)C[C@H]1Cc1cncnc1,,CO,,Cl,C[O-].[Na+],val
US04368201,O=[N+]([O-])O.Oc1ccc2c(c1)CCCC2>>O=[N+]([O-])c1cc2c(cc1O)CCCC2,,CC(=O)O,,,,val
US20100063078A1,Cl.Fc1ccc2c(c1)CCC21CCNC1.O=c1[nH]c(=O)n(CCCCl)cc1-c1cccs1>>Cl.O=c1[nH]c(=O)n(CCCN2CCC3(CCc4cc(F)ccc43)C2)cc1-c1cccs1,,CN1CCCC1=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20090270461A1,CCC(=O)c1ccncc1.NC1CC1>>CCC(NC1CC1)c1ccncc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20140045817A1,CC(C)(C)OC(=O)N1CCC(F)C(Oc2cccc3ccc(-c4nnc5ccccn45)nc23)CC1>>FC1CCNCCC1Oc1cccc2ccc(-c3nnc4ccccn34)nc12,,ClC(Cl)Cl,,Cl,,val
US20030078251A1,CCOC(=O)c1oc2ccc(NC(=O)C[C@H]3O[C@H](c4cccc(OC)c4OC)c4cc(Cl)ccc4N(CC(C)(C)COC(C)=O)C3=O)cc2c1OCC(=O)O>>COc1cccc([C@H]2O[C@H](CC(=O)Nc3ccc4oc(C(=O)O)c(OCC(=O)O)c4c3)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20120184548A1,COc1cc2cc(C(=O)Nc3cc(C(=O)N[C@H](CCNC(=O)OC(C)(C)C)c4ccccc4)ccc3C)c(=O)[nH]c2cc1OC>>COc1cc2cc(C(=O)Nc3cc(C(=O)N[C@H](CCN)c4ccccc4)ccc3C)c(=O)[nH]c2cc1OC,,ClCCl,O=C(O)C(F)(F)F,,,val
US20080262064A1,CCOC(CC)=NC#N.Nc1ccc(F)cc1>>CCC(=NC#N)Nc1ccc(F)cc1,,CCO,,,,val
US20140274688A1,CCOC(=O)/C(C)=C/c1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1>>CCOC(=O)C(C)Cc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1,[Pd],CCOC(C)=O,,,,val
US20160108027A1,CC1CN[C@@H]([C@@H](C)O)CO1.COc1cc(C(=O)O)cc2nc(NCc3cc(Cl)ccn3)oc12>>COc1cc(C(=O)N2CC(C)OC[C@@H]2[C@@H](C)O)cc2nc(NCc3cc(Cl)ccn3)oc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100137281A1,CC(C)(CO)c1ccccc1.CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1>>CCc1cc2c(=O)n(CC(C)(C)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1,,C1CCOC1,O,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20040143115A1,CC(C)(C)OC(=O)N1CCC[C@H]1CN.Clc1cnc(Cl)nc1>>CC(C)(C)OC(=O)N1CCC[C@H]1CNc1ncc(Cl)cn1,,Cc1ccccc1C,,CCN(C(C)C)C(C)C,O=C([O-])[O-].[K+].[K+],val
US05519138,CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)OCC)c2ccccc2)cc1>>CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1,,CCO,,[Na+].[OH-],,val
US04695575,CCOC(=O)Cl.c1ccc(CN2CCC(Cc3nc4ccccc4n3Cc3cccnc3)CC2)cc1>>CCOC(=O)N1CCC(Cc2nc3ccccc3n2Cc2cccnc2)CC1,,Cc1ccccc1,,,,val
US05726182,CCOC(=O)c1cc(C2CC2)c2c(C)c(Cl)c(F)cn2c1=O.C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1CCNC1>>Cc1cc(F)cn2c(=O)c(C(=O)O)c(N3CCC(C(C)N)C3)c(C3CC3)c12.Cl,,CC#N,,O=C([O-])O.[Na+],,val
US20120010228A1,ClCCCBr.O=C1Nc2ccccc2C1(F)F>>O=C1N(CCCCl)c2ccccc2C1(F)F,,CN(C)C=O,,[H-].[Na+],,val
US05556977,CCOC(=O)CCCCCOc1ccc(N(C(=O)OC(C)(C)C)c2ccncc2)cc1>>CCOC(=O)CCCCCOc1ccc(Nc2ccncc2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070066820A1,COC(=O)CCBr.Clc1ccc(Oc2ccc(OC[C@H]3CCCN3)cc2)cc1>>COC(=O)CCN1CCC[C@@H]1COc1ccc(Oc2ccc(Cl)cc2)cc1,,ClCCl,,CCN(CC)CC,O,val
US20090117125A1,COC(=O)c1c(C(=O)OC)c(-c2ccc(Cl)cc2)n2c1Cc1ccccc1C2>>OCc1c(CO)c(-c2ccc(Cl)cc2)n2c1Cc1ccccc1C2,,CCOCC,ClCCl,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20120245144A1,C=C(OCC)c1cc2c(cc1OC)OCCn1cc(-c3nc(C)nn3C(C)C)nc1-2>>COc1cc2c(cc1C(C)=O)-c1nc(-c3nc(C)nn3C(C)C)cn1CCO2,,CC(C)=O,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20110230462A1,Clc1cc(I)ccn1.OB(O)c1cccs1>>Clc1cc(-c2cccs2)ccn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,C1CCOC1,O=C([O-])[O-].[Na+].[Na+],val
US20140128386A1,CC(C)(O)C(CCCC(F)(F)F)NC(=O)OCc1ccccc1.Cl>>CC(C)(O)C(N)CCCC(F)(F)F.Cl,[Pd],CCO,CCOCC,C1=CCCCC1,,val
US20100249163A1,COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(O)c2ccc(Cl)c(Cl)c2)C2CC2)cc(OCCOC)c1>>COCCCc1cc(CN(C(=O)C2CNCCC2(O)c2ccc(Cl)c(Cl)c2)C2CC2)cc(OCCOC)c1,,ClCCl,,Cl,,val
US20120071523A1,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COc1ccc(C(=O)c2coc3c(Cl)cc(O)c(Cl)c23)cc1>>COc1ccc(C(=O)c2coc3c2C(=O)C(=O)C=C3Cl)cc1,,CS(C)=O,,,,val
US20090042811A1,CCCCCCCCCCCCCCCCOC[C@H](CCP(=O)(OCC)OCC)C(=O)c1ccccc1.CO>>CCCCCCCCCCCCCCCCOC[C@@H](O)CCP(=O)(OC)OC,,CO,,CC(=O)O,[Na],val
US20150175557A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)c1ncncc1CN>>CC(C)c1ncncc1CNC(=O)OC(C)(C)C,,C1CCOC1,,CCN(CC)CC,CCOC(C)=O,val
US20090233965A1,CI.CN1CCC(OC(=O)C(C)(c2ccc(Cl)cc2)C2CCCC2)CC1>>CC(C(=O)OC1CC[N+](C)(C)CC1)(c1ccc(Cl)cc1)C1CCCC1.[I-],,CC#N,,,,val
US05457124,O=c1ccoc2c(CCCc3ccccc3)c(OCc3ccccc3)ccc12>>O=C1CCOc2c1ccc(O)c2CCCc1ccccc1,[Pd],CCOC(C)=O,CO,,,val
US20090099155A1,NCCNc1c(Cl)ccc2c1CCN(C(=O)C(F)(F)F)CC2.O=C(Cl)c1ccccc1>>O=C(NCCNc1c(Cl)ccc2c1CCN(C(=O)C(F)(F)F)CC2)c1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US20100286396A1,COc1ccc2c(c1OC)C(C)(C)N1CCc3cc4c(cc3C1=C2C)OCO4>>COc1ccc2c(c1OC)C(C)(C)N1CCc3cc4c(cc3C1C2C)OCO4,,CO,,[BH4-].[Na+],,val
US20100075946A1,CN(C)C=O.O=C(Cc1ccccc1)C(F)(F)F.O=P(Cl)(Cl)Cl>>O=CC(=C(Cl)C(F)(F)F)c1ccccc1,,O,,,,val
US20110118235A1,CCCN(CCC)C(=O)C1=Cc2ccc(-c3ccc(O)cc3)cc2N=C(NC(=O)OC(C)(C)C)C1>>CCCN(CCC)C(=O)C1=Cc2ccc(-c3ccc(O)cc3)cc2N=C(N)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090325988A1,CC(C)(C[C@@](O)(CC#C[Si](C)(C)C)C(F)(F)F)c1ccccc1C(N)=O>>C#CC[C@](O)(CC(C)(C)c1ccccc1C(N)=O)C(F)(F)F,,C1CCOC1,,,,val
US20130102611A1,CCOC(=O)CCCCCCN1CCCc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc21>>Cc1ccc(-c2nc3c(nc2-c2ccc(C)cc2)N(CCCCCCC(=O)O)CCC3)cc1,,C1CCOC1,O,[Li+].[OH-],,val
US20120264739A1,Cc1nn(C(=O)OC(C)(C)C)c2ncccc12.O=C1CCC(=O)N1Br>>BrCc1n[nH]c2ncccc12,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20120088765A1,C/C=C/B(O)O.COc1ccc(CSc2nc(Cl)c3ncn(C)c3n2)cc1[N+](=O)[O-]>>C/C=C/c1nc(SCc2ccc(OC)c([N+](=O)[O-])c2)nc2c1ncn2C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090062280A1,CC(C)(CO)C(=O)O.CCCCN>>CCCCNC(=O)C(C)(C)CO,,CN(C)C=O,ClCCCl,CCN(C(C)C)C(C)C,On1nnc2ccccc21,val
US20150376130A1,CC(C)C=O.Nc1cc2c(cc1C(=O)O)OCCCO2>>CC(C)CNc1cc2c(cc1C(=O)O)OCCCO2,,ClCCCl,ClCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20050085520A1,COC(=O)c1cccc(N2CCOC2=O)c1>>O=C(O)c1cccc(N2CCOC2=O)c1,,C1COCCO1,,[Li+].[OH-],,val
US20060235029A1,CCN(CC)CCCNc1nc(-c2cc(C(=O)O)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1.CN>>CCN(CC)CCCNc1nc(-c2cc(C(=O)NC)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1,,C1CCOC1,ClCCl,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20100120739A1,Cc1ccc2nnc(Cc3ccc4ncc(-c5cn[nH]c5)cc4c3)n2n1.NC(=O)CBr>>Cc1ccc2nnc(Cc3ccc4ncc(-c5cnn(CC(N)=O)c5)cc4c3)n2n1,,CN(C)C=O,,[H-].[Na+],,val
US20150259354A1,CCOC(=O)CP(=O)(OCC)OCC.O=C1CCN(Cc2ccccc2)CC1>>CCOC(=O)C=C1CCN(Cc2ccccc2)CC1,,C1CCOC1,,[H-].[Na+],,val
US20150119385A1,COC(OC)c1nc2c(cc1-n1ccnc1)CCCN2.O=C(Oc1ccccc1)Oc1ccccc1>>COC(OC)c1nc2c(cc1-n1ccnc1)CCCN2C(=O)Oc1ccccc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20130225584A1,Cn1cc(B(O)O)cn1.O=C(Nc1cccnc1)c1cc(Br)c(CN2CCOCC2)cc1OCc1ccccc1>>Cn1cc(-c2cc(C(=O)Nc3cccnc3)c(OCc3ccccc3)cc2CN2CCOCC2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US04829075,NN.O=C(c1ccc(Cl)cc1)C1(n2cncn2)CC1>>NN=C(c1ccc(Cl)cc1)C1(n2cncn2)CC1,,CCO,,O,,val
US20080255078A1,CCC(=O)c1cccc(O)c1.CCOC(=O)CBr>>CCOC(=O)COc1cccc(C(=O)CC)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04853389,CN(C)C=Nc1ncc(S(=O)(=O)NC(C)(C)C)c(Cl)n1.Cc1cccc(N)c1>>Cc1cccc(Nc2nc(N)ncc2S(=O)(=O)NC(C)(C)C)c1,,CCO,,,,val
US05260316,BrCCCc1ccccc1.O=C1NCCc2cc(Br)ccc21>>O=C1c2ccc(Br)cc2CCN1CCCc1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US04595678,CC(=O)OC1C2CC(CBr)(OC(=O)N2)C(OC(C)=O)C1OC(C)=O>>CC(=O)OC1C2CC(C)(OC(=O)N2)C(OC(C)=O)C1OC(C)=O,,Cc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US20140058021A1,COC(=O)CC(=O)OC.COc1ccc(C(=O)C(O)c2ccc(OC)cc2)cc1>>COC(=O)C1=C(c2ccc(OC)cc2)C(c2ccc(OC)cc2)OC1=O,,CO,,Cl,[Na],val
US20080293745A1,COC(=O)CSc1nc2ccc(C)cc2o1>>Cc1ccc2nc(SCC(=O)O)oc2c1,,CO,,[Na+].[OH-],,val
US05719157,CCOC(=O)c1c(CI)nc2cc(OC)c(OC)cc2c1-c1ccc(OC)c(OC)c1.Oc1ccccn1>>CCOC(=O)c1c(Cn2ccccc2=O)nc2cc(OC)c(OC)cc2c1-c1ccc(OC)c(OC)c1,,CN(C)C=O,,O,[H-].[Na+],val
US20110112151A1,COc1cccnc1CO.O=C(C(Br)C12CC3CC(CC(C3)C1)C2)C(Br)C12CC3CC(CC(C3)C1)C2>>COc1cccnc1COC1C2CC3CC(C2)CC1(C(C)=O)C3,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090270361A1,Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1O.O=c1cc(CCl)[nH]c(=O)[nH]1>>Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1OCc1cc(=O)[nH]c(=O)[nH]1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100249101A1,N.O=S(=O)(Cl)c1ccc(Br)cc1Cl>>NS(=O)(=O)c1ccc(Br)cc1Cl,,C1CCOC1,,CCOC(C)=O,O,val
US20080153871A1,C=CC#N.O=Cc1ccccc1O>>N#CC1=Cc2ccccc2OC1,,[Na+],[OH-],C1CN2CCN1CC2,,val
US20060189636A1,CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cnc3c(CCc4ccccc4)ncnc32)C[C@@H]1O.CI>>CO[C@H]1C[C@H](n2cnc3c(CCc4ccccc4)ncnc32)O[C@@H]1CO[Si](C)(C)C(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20160002175A1,CNc1cc(Cl)nc(N)n1.I>>CNc1cc(I)nc(N)n1,,CC(C)=O,,[I-].[Na+],,val
US04238614,C[Mg]Br.OCc1cccc(Oc2ccccc2)n1>>CC1(CO)C=CC=C(Oc2ccccc2)N1,,C1CCOC1,,,,val
US20080021023A1,CCOC(=O)CBr.O=c1[nH]c2ccccc2o1>>CCOC(=O)Cn1c(=O)oc2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US20130237555A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC(CCC(F)(F)F)C(=O)O>>CC(C)(C)OC(=O)NC(CCC(F)(F)F)C(=O)O,,C1CCOC1,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20120270838A1,CN(C)C(OC(C)(C)C)OC(C)(C)C.Cc1cc(C(=O)O)ccc1CCS(=O)(=O)N1CCC(=O)CC1>>Cc1cc(C(=O)OC(C)(C)C)ccc1CCS(=O)(=O)N1CCC(=O)CC1,,CCOC(C)=O,Cc1ccccc1,,,val
US20090247551A1,CONCc1cnc(Cl)c(Cl)c1.O=C1COC(=O)C1>>CON(Cc1cnc(Cl)c(Cl)c1)C1=CC(=O)OC1,,Cc1ccccc1,,CC(=O)O,O,val
US20090221584A1,Cc1cc(N)nnc1Sc1ccc(S(=O)(=O)N2CCCCC2)cc1.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1Cl>>Cc1cc(NS(=O)(=O)c2ccc(C(F)(F)F)cc2Cl)nnc1Sc1ccc(S(=O)(=O)N2CCCCC2)cc1,,c1ccncc1,,,,val
US20100048561A1,CNCCOC.NS(=O)(=O)c1ccc(Nc2ncc3cccc(C=O)c3n2)cc1>>COCCN(C)Cc1cccc2cnc(Nc3ccc(S(N)(=O)=O)cc3)nc12,CC(=O)O,CN1CCCC1=O,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US05085686,CC(=O)O.COc1cccc(-n2cncn2)c1C(N)=O>>COc1cccc(-n2cncn2)c1C(=O)O,,Cl,,,,val
US20100249118A1,Brc1cnc2[nH]ccc2c1.CCCS(=O)(=O)Nc1cccc(C=O)c1F>>CCCS(=O)(=O)Nc1cccc(C(O)c2c[nH]c3ncc(Br)cc23)c1F,,CO,,O,[K+].[OH-],val
US20130344030A1,C=C[C@](C)(COC)C(=O)O.CO>>C=C[C@](C)(CO)C(=O)OC,,ClCCl,,BrB(Br)Br,,val
US20110034450A1,O=C1NC(O)c2c(F)cccc21>>O=C1NCc2c(F)cccc21,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20070173501A1,CC1(C)OC(=O)C=C1Br.O=C1Cc2ccc(F)cc2N1>>CC1(C)O/C(=C2/C(=O)Nc3cc(F)ccc32)C=C1Br,,C1CCOC1,O,Cl,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],val
US20040229861A1,C=CC[C@@H](NC(=O)OCc1ccccc1)C(=O)N(CC(=C)Br)Cc1ccc(OC)cc1OC.OB(O)c1ccccc1>>C=CC[C@@H](NC(=O)OCc1ccccc1)C(=O)N(CC(=C)c1ccccc1)Cc1ccc(OC)cc1OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20110184188A1,C[Mg]Cl.O=[N+]([O-])c1ccc(Cn2nc(C(F)(F)F)nc2C(F)(F)F)c(F)c1>>Cc1c([N+](=O)[O-])ccc(Cn2nc(C(F)(F)F)nc2C(F)(F)F)c1F,,C1CCOC1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US20110212937A1,Br[Mg]c1ccccc1.C=Cc1c(NC)nc(Cl)nc1C(=O)N(C)OC>>C=Cc1c(NC)nc(Cl)nc1C(=O)c1ccccc1,,C1CCOC1,,CCOC(C)=O,,val
US20100221176A1,C#CCOCCOCCOCCOCCOCCOCCO.O=C1C=CC(=O)N1>>C#CCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04333934,CCn1c(=O)c2nc(C=NO)cn2c2ccccc21>>CCn1c(=O)c2nc(C#N)cn2c2ccccc21,,CC(=O)OC(C)=O,,,,val
US05151431,O=C(O)CCNc1cc(Cl)c(Cl)cc1[N+](=O)[O-]>>O=C1CCNc2c([N+](=O)[O-])cc(Cl)c(Cl)c21,,Cc1ccccc1,,O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3,,val
US20050014812A1,CCCCCI.Oc1cnc(Cl)c(Cl)c1>>CCCCCOc1cnc(Cl)c(Cl)c1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160264518A1,COC(=O)/C=C/c1ccccc1NCc1ccc(S(C)(=O)=O)cc1.NO>>CS(=O)(=O)c1ccc(CNc2ccccc2/C=C/C(=O)NO)cc1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20130052137A1,Nc1ccccn1.O=C(O)c1ccc([N+](=O)[O-])cc1>>O=C(Nc1ccccn1)c1ccc([N+](=O)[O-])cc1,,CN(C)C=O,ClCCl,CCN(CC)CC,O=C(Cl)C(=O)Cl,val
US04436748,COc1cc2cc(C)sc2c(Cl)c1Cl>>Cc1cc2cc(O)c(Cl)c(Cl)c2s1,,O,,Cl,c1ccncc1,val
US20160031857A1,CN(C)C(=O)COc1ccc2c(c1)N(c1nc(Cl)nc3c1CS(=O)C3)CC2.OB(O)c1cccnc1>>CN(C)C(=O)COc1ccc2c(c1)N(c1nc(-c3cccnc3)nc3c1CS(=O)C3)CC2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US04882330,CC(=O)Nc1ccc(N2CCN(Cc3ccccc3)CC2)cc1>>CC(=O)Nc1ccc(N2CCNCC2)cc1,[Pd],CO,,,,val
US20010036946A1,CC(C)(C)OC(=O)N1CCNCC1.O=C1CCN(Cc2ccccc2)CC1>>CC(C)(C)OC(=O)N1CCN(C2CCN(Cc3ccccc3)CC2)CC1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US05656645,Cc1ccc(C(=O)O)c(=O)n1CC(=O)OC(C)(C)C.OCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cc1ccc(NC(=O)OCc2ccccc2)c(=O)n1CC(=O)OC(C)(C)C,,C1COCCO1,,CCN(CC)CC,,val
US20160221946A1,CN(Cc1cn(S(=O)(=O)c2cccnc2)c2cc(CBr)ccc12)C(=O)OC(C)(C)C.Cc1ccc(B(O)O)c(Cl)c1>>Cc1ccc(Cc2ccc3c(CN(C)C(=O)OC(C)(C)C)cn(S(=O)(=O)c4cccnc4)c3c2)c(Cl)c1,,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20090012061A1,COc1ccc2ccc(C(=O)O)cc2c1>>O=C(O)c1ccc2ccc(O)cc2c1,,Br,,,,val
US20070298104A1,N#Cc1ccc([N+](=O)[O-])cc1C#N.Oc1ccc(OCc2ccccc2)cc1>>N#Cc1ccc(Oc2ccc(OCc3ccccc3)cc2)cc1C#N,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100144745A1,CC1(C)CCCC(=O)C1.NCc1ccccc1>>CC1(C)CCCC(NCc2ccccc2)C1,,O,c1ccccc1,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05998438,C1=COC(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1>>c1cc2[nH]cc(CCN3CCCC3)c2cc1C1CCCCO1,,CCO,,Cl,[BH3-]C#N.[Na+],val
US20090048263A1,Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.c1ccc(-c2ccc(N3CCNCC3)nc2)cc1>>Cc1noc(NC(=O)N2CCN(c3ccc(-c4ccccc4)cn3)CC2)c1C,,O,,CCN(C(C)C)C(C)C,CS(C)=O,val
US06552068B1,CS(=O)(=O)OCCCCCCC(F)(F)C(F)(F)F.[I-]>>FC(F)(F)C(F)(F)CCCCCCI,,CC(C)=O,,O,,val
US08431695B2,N#Cc1ccc([C@@H]2CCCN(C(=O)OCc3ccccc3)C2)n1N.N=CN>>Nc1ncnn2c([C@@H]3CCCN(C(=O)OCc4ccccc4)C3)ccc12,,CCCCO,,CC(=O)O,,val
US20050197330A1,CI.Cn1nc2c(c1Br)CCCN2c1ccc(Cl)cc1Cl>>Cc1c2c(nn1C)N(c1ccc(Cl)cc1Cl)CCC2,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US04952493,Cc1cc(=O)oc2cc(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc3ccccc3)NC(=O)OC(C)(C)C)ccc12.O=C(O)C(F)(F)F>>Cc1cc(=O)oc2cc(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)Cc3ccccc3)ccc12.O=C(O)C(F)(F)F,,Cc1ccccc1,,,,val
US05905071,CC(C)(C)OC(=O)N[C@@H](CC(=O)O)C(=O)OC(C)(C)C.CCCCCCCC/C=C\CCCCCCCC(=O)N(CCCCCCCCCCCCCCCCCC)[C@]1(N)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1C(=O)[C@H](C)N>>CCCCCCCC/C=C\CCCCCCCC(=O)N(CCCCCCCCCCCCCCCCCC)[C@]1(N)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C,,ClCCl,,,,val
US20110059951A1,CC(C)(C)OC(=O)N1CCCN(CC(O)CC#N)CC1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCCN(CC(CC#N)OS(C)(=O)=O)CC1,,ClCCl,O,CCN(CC)CC,,val
US20050256171A1,COC(=O)[C@@H]1CC(N=[N+]=[N-])CN1C(=O)CCc1ccc(CNC(=O)OC(C)(C)C)cc1>>COC(=O)C1CC(N)CN1C(=O)CCc1ccc(CNC(=O)OC(C)(C)C)cc1,[Pd],CO,,,,val
US20070232591A1,CC(C)(C)OC(=O)Nc1cnccc1C=O.CCOC=CC(=O)OCC>>CCOC(=O)c1cnc2cnccc2c1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US06124283,CC(=O)Oc1cccc(C(=O)O)c1.CN1CCN(c2cccc3c2C[C@H](N)CC3)CC1>>CN1CCN(c2cccc3c2C[C@H](NC(=O)c2cccc(O)c2)CC3)CC1,,ClCCl,O=S(Cl)Cl,CCN(CC)CC,,val
US20080319188A1,CN1CCNCC1.O=C(Oc1ccccc1)N(C(=O)Oc1ccccc1)c1cc(Oc2ccc(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)c(F)c2)ccn1>>CN1CCN(C(=O)Nc2cc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)c(F)c3)ccn2)CC1,,CN(C)C=O,,,,val
US20120115862A1,ClCCN1CCOCC1.O=C1c2ccc(Cl)cc2CCc2c(O)cccc21>>O=C1c2ccc(Cl)cc2CCc2c(OCCN3CCOCC3)cccc21,,CC#N,,Cl,O=C([O-])[O-].[K+].[K+],val
US20140011856A1,CC(O)C(=O)O.CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21>>CC(O)C(=O)O.CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21,,ClCCl,,CC#N,,val
US20080275043A1,Fc1cccc(Cl)c1CBr.O=C1CCCCN1C1CCCCC1>>O=C1C(Cc2c(F)cccc2Cl)CCCN1C1CCCCC1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20140329798A1,COC(=O)Cc1ccc(O)cc1.OCC[C@@H]1C[C@@H]1C1CCN(c2ncc(Cl)cn2)CC1>>COC(=O)Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20100310512A1,COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc(C#C[Si](C)(C)C)cc2)[nH]1)C(C)C>>C#Cc1ccc(-c2cnc(C3CCCN3C(=O)C(NC(=O)OC)C(C)C)[nH]2)cc1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20130190330A1,BrC(Br)(Br)Br.OCc1cnc(-c2ccccc2Cl)o1>>Clc1ccccc1-c1ncc(CBr)o1,,C1CCOC1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20010039286A1,CNC.O=C1CCN(Cc2ccccc2)CC1.[C-]#N>>CN(C)C1(C#N)CCN(Cc2ccccc2)CC1,,CCO,O,Cl,,val
US20140171412A1,CO.NC[C@H](NC(=O)OCc1ccccc1)C(=O)O>>COC(=O)C(CN)NC(=O)OCc1ccccc1,,CO,,CC(=O)Cl,,val
US20100190775A1,NNC(=O)c1cccc([N+](=O)[O-])c1.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]nc(-c2cccc([N+](=O)[O-])c2)o1,,C1CCOC1,,Cl,O,val
US20040006079A1,O=C(OO)c1cccc(Cl)c1.O=c1c2c([nH]c3ccccc13)C(c1ccc3c(c1)OCO3)N(Cc1ccccc1)C2>>O=C1c2ccccc2NC23OC12CN(Cc1ccccc1)C3c1ccc2c(c1)OCO2,,ClCCl,,CO,,val
US04472405,CCOC=C(C(=O)OCC)C(=O)OCC.Cc1c(F)ccc2c1CCC(C)N2>>Cc1c(F)cc2c(=O)c(C(=O)O)cn3c2c1CCC3C,,[Na+],[OH-],Cl,,val
US20120122890A1,CC1(C)[C@H]2CC[C@@H](CC(=O)O)[C@@H]1C2.O=S(Cl)Cl>>CC1(C)[C@H]2CC[C@@H](CC(=O)Cl)[C@@H]1C2,,CN(C)C=O,,,,val
US20080261969A1,Nc1cc(F)cc(F)c1N.S=C(n1ccnc1)n1ccnc1>>Fc1cc(F)c2[nH]c(S)nc2c1,,C1CCOC1,,,,val
US20060025414A1,CN=C=S.Clc1cccc(-c2cc(C3CCCCN3)no2)c1>>CNC(=S)N1CCCCC1c1cc(-c2cccc(Cl)c2)on1,,ClCCl,,,,val
US04406897,CNN.COc1nc(-c2ccccc2)n(C)c(=O)n1>>CNNc1nc(-c2ccccc2)n(C)c(=O)n1,,CO,,,,val
US04738975,CCCI.COc1c(C)[nH]ccc1=O>>CCCOc1ccnc(C)c1OC,O=[Ag],CN(C)C=O,ClC(Cl)Cl,,,val
US20100076004A1,COC(CNC1=NC(=O)N(c2cc(F)ccc2-c2ccc(S(C)(=O)=O)cc2)C12CCN(Cc1ccccc1)C(C)C2)OC>>CC1CC2(CCN1Cc1ccccc1)c1nccn1C(=O)N2c1cc(F)ccc1-c1ccc(S(C)(=O)=O)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20040147561A1,CCOC(=O)c1cc(C(=O)CBr)c(=O)[nH]c1C.NC(=S)c1c(Cl)cccc1Cl>>CCOC(=O)c1cc(-c2csc(-c3c(Cl)cccc3Cl)n2)c(=O)[nH]c1C,,CCO,,,,val
US20050032786A1,CC(C)(C)OC(=O)CN.O=C(O)CCc1cccc(-c2nc(=O)c3ccccc3s2)n1>>CC(C)(C)OC(=O)CNC(=O)CCc1cccc(-c2nc(=O)c3ccccc3s2)n1,,CN(C)C=O,,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US20040043994A1,C=CC(C)(CC(=O)OCC)Cc1ccc(OCCCNC2C=CC=CN2O)cc1>>C=CC(C)(CC(=O)OCC)Cc1ccc(OCCCNc2ccccn2)cc1,,CC(=O)O,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20040204586A1,C1CNCCN1.N#Cc1c(Cl)c2cc(F)ccc2n(Cc2ccc(F)cc2)c1=O>>N#Cc1c(N2CCNCC2)c2cc(F)ccc2n(Cc2ccc(F)cc2)c1=O,,ClCCl,,,,val
US05468858,C=O.CC(C)N.CC(C)N1CCC(=O)CC1.CCOCC>>CC(C)N1CC2CN(C(C)C)CC(C1)C2=O,,CCOCC,O,CC(=O)O,[Na+].[OH-],val
US20080021226A1,COc1ccc(COC/C=C(\C)C(OC)OC)cc1>>COc1ccc(COC/C=C(\C)C=O)cc1,,CC#N,,Cl,O=C([O-])O.[Na+],val
US20020115674A1,O=c1c2cc(F)c(N3CCCC3)cc2n(-c2ccc(F)cc2F)c(=O)n1OCc1ccccc1>>O=c1c2cc(F)c(N3CCCC3)cc2n(-c2ccc(F)cc2F)c(=O)n1O,[Pd],C1CCOC1,,[H][H],,val
US20050026964A1,Cc1ccc(Nc2cc(=O)n(C)cc2C(=O)O)c(F)c1.NOCCO>>Cc1ccc(Nc2cc(=O)n(C)cc2C(=O)NOCCO)c(F)c1,,CO,,COc1nc(OC)nc([N+]2(C)CCOCC2)n1.[Cl-],,val
US04268510,COC(=O)c1ccc([N+](=O)[O-])c(C(N)=O)c1>>COC(=O)c1ccc(N)c(C(N)=O)c1,[Pd],CO,,,,val
US05658922,CC(=O)OC1CC[C@@]2(C)C(=CC(=O)[C@H]3[C@@H]4CC[C@H](C(C)O[Si](C)(C)C(C)(C)C)[C@@]4(C)CC[C@@H]32)C1.C[Mg]Cl>>CC(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@@]1(C)CCC(O)CC1=CC3(C)O,,C1CCOC1,,,,val
US20110065708A1,C/C(=N\OCCO)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1.O=C1NC(=O)c2ccccc21>>C/C(=N\OCCN1C(=O)c2ccccc2C1=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050256140A1,CN(C)C=O.CSc1ncnc2ccoc12>>CSc1ncnc2cc(C=O)oc12,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20100113528A1,N#Cc1ccc(Br)c(C(F)(F)F)c1.OB(O)C1=CCCCC1>>NC(=O)c1ccc(C2=CCCCC2)c(C(F)(F)F)c1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CO,,C[O-].[Na+],,val
US20130096160A1,Brc1csc(Br)n1.CC(C)(C)OC(=O)NC1CCNCC1>>CC(C)(C)OC(=O)NC1CCN(c2nc(Br)cs2)CC1,,C1COCCO1,O,,,val
US20100048561A1,COc1cc2nc(Cl)ncc2cc1Br.Nc1ccc(N2CCOCC2)cc1>>COc1cc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2cc1Br,,CC(C)O,,,,val
US20070225372A1,C=CCI.O=C1CN(C(=O)OCc2ccccc2)CCN1>>C=CCN1CCN(C(=O)OCc2ccccc2)CC1=O,,C1CCOC1,,[H-].[Na+],,val
US20140249104A1,Clc1cc(Br)cc(Cl)n1.OB(O)c1ccccc1>>Clc1cc(-c2ccccc2)cc(Cl)n1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20090286768A1,O=C1NC(=O)c2ccccc21.OC(c1ccc(Oc2ccccc2)cc1)c1nccnc1Cl>>O=C1c2ccccc2C(=O)N1C(c1ccc(Oc2ccccc2)cc1)c1nccnc1Cl,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080171732A1,CCOC(=O)c1cc(C#N)c(=O)[nH]c1COCc1ccc(OC)c(OC)c1.CS(=O)(=O)Cl>>CCOC(=O)c1cc(C#N)c(OS(C)(=O)=O)nc1COCc1ccc(OC)c(OC)c1,,ClCCl,O,CCN(C(C)C)C(C)C,Cl,val
US20110003800A1,CI.Cc1ccc([N+](=O)[O-])c(N)c1>>CNc1cc(C)ccc1[N+](=O)[O-],,CN(C)C=O,,[H-].[Na+],,val
US20070191603A1,CC=COc1ccc(C(=O)OC)cc1N(C=CC)S(=O)(=O)c1cc(Cl)ccc1OC>>COC(=O)c1ccc2c(c1)N(S(=O)(=O)c1cc(Cl)ccc1OC)C=CO2,,Cc1ccccc1,,,,val
US20140128372A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC(O)c1ccc(Cl)cc1>>CC(C)(C)OC(=O)NCC(O)c1ccc(Cl)cc1,,ClCCl,,CCN(CC)CC,Cl,val
US03987052,CC(=O)NN.CCSc1cccc2c1C(c1ccccc1Br)=NCC(=S)N2>>CCSc1cccc2c1C(c1ccccc1Br)=NCc1nnc(C)n1-2,,CCO,,,,val
US20100168039A1,CC(C)(C)OC(=O)COc1ccc([C@@H]2[C@@H](SSc3ncccc3[N+](=O)[O-])C(=O)N2c2ccc(F)cc2)cc1.O=C(CBr)c1ccc2c(c1)OCCO2>>O=C(O)COc1ccc([C@@H]2[C@@H](SCC(=O)c3ccc4c(c3)OCCO4)C(=O)N2c2ccc(F)cc2)cc1,,CC(C)=O,O,CCN(CC)CC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120149681A1,CC(C)(C)OC(=O)N1CCC(Oc2cc(Br)cc(CO)c2)CC1>>CC(C)(C)OC(=O)N1CCC(Oc2cc(Br)cc(C=O)c2)CC1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,O=C([O-])O.[Na+],val
US05763437,NC1N=C(c2ccccc2F)c2ccccc2N(CC(=O)N2CC3CCC(CC3)C2)C1=O.O=C(n1ccnc1)n1ccnc1>>O=C(CN1C(=O)C(NC(=O)n2ccnc2)N=C(c2ccccc2F)c2ccccc21)N1CC2CCC(CC2)C1,,O,,CCOC(C)=O,,val
US20160244441A1,CN(C)c1ccn2cc(-c3ccc(O)cc3)nc2c1.FCCBr>>CN(C)c1ccn2cc(-c3ccc(OCCF)cc3)nc2c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040209935A1,NCc1ccc(-c2c[nH]nc2-c2c[nH]c(C(=O)NC(CO)c3ccc(F)c(Cl)c3)c2)cc1Cl.O=C1CCCO1>>O=C(CCCO)NCc1ccc(-c2c[nH]nc2-c2c[nH]c(C(=O)NC(CO)c3ccc(F)c(Cl)c3)c2)cc1Cl,,CS(C)=O,ClCCl,C[Al](C)C,,val
US20100029718A1,Cc1nc(N)sc1C(=O)NCc1ccccc1.O=C(O)CCCBr>>Cc1nc(NC(=O)CCCBr)sc1C(=O)NCc1ccccc1,,C1CCOC1,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20090062498A1,COB(O)c1ccc(C(=O)O)cc1.COC(=O)c1cc(Br)cc(C(=O)OC)c1>>O=C(O)c1ccc(-c2cc(C(=O)O)cc(C(=O)O)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,O,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],val
US20090298830A1,C1COCCN1.COc1cc([N+](=O)[O-])ccc1Cl>>COc1cc([N+](=O)[O-])ccc1N1CCOCC1,,CCOC(C)=O,,,,val
US04656167,COc1cccc2c1CC=CC2.O=C(OO)c1cccc(Cl)c1>>COc1cccc2c1CC1OC1C2,,ClCCl,,,,val
US20020019424A1,COC(=O)C1CCC(c2ccc(F)cc2)N1S(=O)(=O)c1ccc(C)cc1.[NH4+]>>Cc1ccc(S(=O)(=O)N2C(C(N)=O)CCC2c2ccc(F)cc2)cc1,,CO,,O,,val
US20100190763A1,CCN(C(=O)OC(C)(C)C)[C@@H](C)C(=O)OC>>CCN[C@@H](C)C(=O)OC,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080033002A1,COC(=O)C1=CCC2(CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21>>CC(C)(C)OC(=O)N1CCC2(CC=C(C(=O)O)c3ccccc32)CC1,,CO,,Cl,[Na+].[OH-],val
US20090036678A1,COC(=O)C1=CC[C@H](NC(c2ccccc2)(c2ccccc2)c2ccccc2)C1>>OCC1=CC[C@H](NC(c2ccccc2)(c2ccccc2)c2ccccc2)C1,,Cc1ccccc1,,CC(C)C[Al+]CC(C)C.[H-],,val
US20020147339A1,CC(C)(C)OC(=O)NC(C)(C)c1ccc(-c2ccno2)cc1>>CC(C)(C)OC(=O)NC(C)(C)c1ccc(C(=O)CC#N)cc1,,CCO,,C,C[O-].[Na+],val
US08138168B1,CC(C)(C)OC(=O)N[C@@H](CC(=O)O)Cc1ccc(Br)cc1.COCCCn1c([C@@H]2CCCNC2)nc2ccncc21>>COCCCn1c([C@@H]2CCCN(C(=O)C[C@@H](Cc3ccc(Br)cc3)NC(=O)OC(C)(C)C)C2)nc2ccncc21,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04596816,O=S(Cl)Cl.OCCc1ocnc1-c1ccccc1>>ClCCc1ocnc1-c1ccccc1,,ClC(Cl)Cl,,CN(C)C=O,,val
US20100286117A1,CC(C)N.COC(=O)c1ccc(OCc2c(CCC(F)(F)F)noc2C)nc1.C[Al](C)C.Cc1ccccc1>>CC(C)OC(C)C.Cc1onc(CCC(F)(F)F)c1COc1ccc(C(=O)NC(C)C)cn1,,C1COCCO1,Cc1ccccc1,,,val
US20060200873A1,COc1ccccc1C(=O)O>>O=C(O)c1ccccc1O,,CO,,,,val
US20100317607A1,CC(C)(C)OC(=O)N1CCN(c2nc(NCc3ccccc3)c3ccccc3n2)CC1>>c1ccc(CNc2nc(N3CCNCC3)nc3ccccc23)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090130076A1,O=[N+]([O-])c1ccc(Cc2cc(-c3cccc(Cl)c3)c3ncsc3c2)cc1>>Nc1ccc(Cc2cc(-c3cccc(Cl)c3)c3ncsc3c2)cc1,[Pd],CCOC(C)=O,CCOCC,Cl,,val
US20110152287A1,CC(C)(C)OC(=O)N[C@@H](Cc1cccs1)C(=O)O.COc1ccc(NC(=O)c2ccc3nc(N4CCNCC4)sc3c2)cc1OC>>COc1ccc(NC(=O)c2ccc3nc(N4CCN(C(=O)[C@H](Cc5cccs5)NC(=O)OC(C)(C)C)CC4)sc3c2)cc1OC,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060148858A1,COC(=O)Cc1cccc(OC)c1O.COc1ccc(-n2cc(CCCO)c(C(C)C)n2)nn1>>COc1ccc(-n2cc(CCCOc3c(CC(=O)O)cccc3OC)c(C(C)C)n2)nn1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20120015907A1,C=CCN(CCBr)S(=O)(=O)c1ccccc1[N+](=O)[O-].CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(NS(C)(=O)=O)c(I)cc12>>C=CCN(CCN(c1nc2oc(-c3ccc(F)cc3)c(C(=O)NC)c2cc1I)S(C)(=O)=O)S(=O)(=O)c1ccccc1[N+](=O)[O-],,CC(=O)N(C)C,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(O)cc(C)c21.O=[N+]([O-])c1cc(Cl)ccn1>>CCOC(=O)CC1OB(O)c2cc(Oc3cc(Cl)ccn3)cc(C)c21,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100137311A1,Cc1nc(NCc2ccc(C(F)(F)F)cc2)nc(N)c1N.O=C(Cl)CC1CCCC1>>Cc1nc(NCc2ccc(C(F)(F)F)cc2)nc(N)c1NC(=O)CC1CCCC1,,CC#N,,,,val
US20080242672A1,CC(Cn1ccc2c1nc(N)n1nc(-c3ccco3)nc21)OS(C)(=O)=O.Fc1ccc(N2CCNCC2)c(F)c1>>CC(Cn1ccc2c1nc(N)n1nc(-c3ccco3)nc21)N1CCN(c2ccc(F)cc2F)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20020107273A1,CCc1nc2c(C)cc(C)nc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1.CN>>CCc1nc2c(C)cc(C)nc2n1-c1ccc(CCN(C)C(=O)NS(=O)(=O)c2ccc(C)cc2)cc1,,O,,,,val
US04517384,ClCCCl.FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CCS>>FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CCSCCCl,,O,,[Na+].[OH-],,val
US20040082607A1,CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)C)c(=O)c2ccc(-c3ccccc3)cc12.Cl>>CCCCOc1c(CN)n(CC(C)C)c(=O)c2ccc(-c3ccccc3)cc12.Cl,,CCOC(C)=O,,,,val
US20080153836A1,COC1CCC(OC)O1.CS(=O)(=O)Nn1c(=O)[nH]c2cc(C(F)(F)F)c(CN)cc2c1=O>>CS(=O)(=O)Nn1c(=O)[nH]c2cc(C(F)(F)F)c(Cn3cccc3)cc2c1=O,,CC(=O)O,,,,val
US20140128392A1,CCc1nc2cc(C(=O)OC)ccc2nc1-c1ccccc1>>CCc1nc2cc(C(=O)O)ccc2nc1-c1ccccc1,,CO,,[Na+].[OH-],,val
US20160264544A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)CBr.COC(=O)[C@H](N)CS>>COC(=O)CSC[C@@H](NC(=O)OC(C)(C)C)C(=O)OC,,ClCCl,,CCN(CC)CC,Cl,val
US08946492B2,C=C(c1cc(Cl)cc(Cl)c1)C(F)(F)F.CC1=C(Br)C=CC(Cl)(C=NO)C1>>Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1Br,,C1CCOC1,,O=C([O-])O.[K+],,val
US20130059835A1,COc1c(C(C)=O)cc(Cl)c(C)c1C1CN(C(=O)OC(C)(C)C)C1>>COc1c(C(C)O)cc(Cl)c(C)c1C1CN(C(=O)OC(C)(C)C)C1,,CO,,[BH4-].[Na+],,val
US04621901,N#C[C@@H]1CC[C@@H](C=O)CC1>>N#C[C@@H]1CC[C@@H](CO)CC1,,CCOCC,CO,Cl,[BH4-].[Na+],val
US20080280876A1,CC(C)Oc1ccc(-c2noc(-c3ccc(OC[C@@H]4COC(C)(C)O4)cc3)n2)cc1Cl>>CC(C)Oc1ccc(-c2noc(-c3ccc(OC[C@@H](O)CO)cc3)n2)cc1Cl,,C1CCOC1,,Cl,[Na+].[OH-],val
US20110079557A1,C1CNCCNCCCNCCNC1.CCOC(=O)CBr>>CCOC(=O)CN1CCCNCCNCCCNCC1,,ClC(Cl)Cl,,O=C([O-])[O-].[K+].[K+],,val
US20050239797A1,CN1CCNCC1.O=[N+]([O-])c1ccc2ncnc(Cl)c2c1>>CN1CCN(c2ncnc3ccc([N+](=O)[O-])cc23)CC1,,ClCCl,,,,val
US20130231509A1,COCCCOc1cc(C[C@@H](CO)C(C)C)ccc1OC.O=P(Br)(Br)Br>>COCCCOc1cc(C[C@@H](CBr)C(C)C)ccc1OC,,CN(C)C=O,,CO,O,val
US20060287342A1,FC(F)(F)c1ccc(CCl)cn1.O=c1[nH]nc2nc(-c3ccncc3)c(-c3ccc(Cl)cc3)cn12>>O=c1n(Cc2ccc(C(F)(F)F)nc2)nc2nc(-c3ccncc3)c(-c3ccc(Cl)cc3)cn12,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US05795892,Cc1cc(O)cc(N2C(=O)c3ccccc3C2=O)c1.N#CCCl>>Cc1cc(OCC#N)cc(N2C(=O)c3ccccc3C2=O)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US04645765,CC(=O)OC(C)=O.O=Cc1cc(O)c2c(c1)N1CC3NC3C(O)(O1)C2CO>>CC(=O)N1C2CN3OC(O)(C(CO)c4c(O)cc(C=O)cc43)C21,,CO,,,,val
US20060166985A1,C1COCCN1.CCOC[C@H](NC(=O)OC(C)(C)C)C(=O)O>>CCOC[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCOCC1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20080318957A1,COC(=O)[C@H](CCC(=S)N(CCNC(=O)OC(C)(C)C)CCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NCCN(CCNC(=O)OC(C)(C)C)C(=S)CC[C@H](NC(=O)OC(C)(C)C)C(=O)O,,CO,,[Na+].[OH-],,val
US20140179666A1,CC(=O)OC(C)=O.CC1(C)CNc2ccc(Br)cc21>>CC(=O)N1CC(C)(C)c2cc(Br)ccc21,,ClCCl,,c1ccncc1,,val
US20020147342A1,CC#CCBr.Oc1ccc(O)cc1>>CC#CCOc1ccc(O)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06613942B1,CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NN.On1nnc2ccccc21>>NNC(=O)c1ccc(O)c(Cl)c1,,ClCCl,,O,,val
US20130184241A1,Cc1ccc(B(O)O)cc1.O=[N+]([O-])c1ccc(Cl)nc1>>Cc1ccc(-c2ccc([N+](=O)[O-])cn2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20160039838A1,Nc1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1.O=C(Cl)/C=C/CBr>>O=C(/C=C/CBr)Nc1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1,,C1CCOC1,,O,,val
US20160075696A1,COCOC[C@@H]1[C@@H]2CC[C@@H]([C@@H](O)C2)N1C(=O)OC(C)(C)C>>COCOC[C@@H]1[C@@H]2CC[C@@H](C(=O)C2)N1C(=O)OC(C)(C)C,,CCOC(C)=O,,,,val
US03953490,N#CC(Br)c1ccc(Cl)cc1.Oc1cccc(C(F)(F)F)c1>>N#CC(Oc1cccc(C(F)(F)F)c1)c1ccc(Cl)cc1,,ClCCl,,O=C([O-])[O-].[K+].[K+],,val
US20120009151A1,CS(=O)(=O)N1CCC(Nc2nc(Cl)nc(Nc3ccc(F)c(Cl)c3)n2)C1.OCC(F)(F)F>>CS(=O)(=O)N1CCC(Nc2nc(Nc3ccc(F)c(Cl)c3)nc(OCC(F)(F)F)n2)C1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20040132694A1,CN1CCN(C(=O)c2cccc(Nc3c(Cl)c(=O)c3=O)c2O)CC1.Nc1ccccc1>>CN1CCN(C(=O)c2cccc(Nc3c(Nc4ccccc4)c(=O)c3=O)c2O)CC1,,CS(C)=O,,,,val
US20100104532A1,CC(=O)OC(C)=O.CCOP(=O)(OCC)C(C[C@H]1O[C@H](OC)[C@H](OC(=O)c2ccccc2)[C@@H]1F)Sc1ccccc1>>CCOP(=O)(OCC)C(C[C@H]1O[C@@H](OC(C)=O)[C@H](OC(=O)c2ccccc2)[C@@H]1F)Sc1ccccc1,,CC(=O)O,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20090286790A1,Br[Mg]c1ccccc1.CCC1CC2(CC(C=O)N1C(=O)OC(C)(C)C)OCCO2>>CCC1CC2(CC([C@H](O)c3ccccc3)N1C(=O)OC(C)(C)C)OCCO2,,C1CCOC1,,[Cl-].[NH4+],,val
US20160251380A1,BrCCOCc1ccccc1.Oc1ccc(F)cc1Br>>Fc1ccc(OCCOCc2ccccc2)c(Br)c1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20080176829A1,CC1c2c(ccc3[nH]ccc23)OCCN1C(=O)OC(C)(C)C.O=S(=O)(Cl)c1ccc(Cl)cc1Cl>>CC1c2c(ccc3c2ccn3S(=O)(=O)c2ccc(Cl)cc2Cl)OCCN1C(=O)OC(C)(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20060166997A1,COc1ccc(C(O)C(=O)OCc2ccccc2)cc1OC.CS(=O)(=O)Cl>>COc1ccc(C(Cl)C(=O)OCc2ccccc2)cc1OC,,ClCCl,,CCN(CC)CC,,val
US20040224969A1,C=Cc1ccc(C)cc1C.CCOC(=O)C=O.Nc1cc(Cl)cc(Cl)c1>>Cc1ccc(C2CC(C(=O)O)Nc3cc(Cl)cc(Cl)c32)c(C)c1,,CC#N,CCO,O=C(O)C(F)(F)F,[Na+].[OH-],val
US05306718,C#CCC#CCO.O=C1c2ccccc2C(=O)N1O>>C#CCC#CCON1C(=O)c2ccccc2C1=O,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06011050,CN(C)c1cccc2c1C(=O)OC2=O.COc1ccc(C(N)CS(C)(=O)=O)cc1OC1CCCC1>>COc1ccc(C(CS(C)(=O)=O)N2C(=O)c3cccc(N(C)C)c3C2=O)cc1OC1CCCC1,,CC(=O)O,,,,val
US20050070562A1,Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1CCNCC1.Nc1ccc(C(=O)O)cn1>>Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1CCN(C(=O)c2ccc(N)nc2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080300232A1,O=C(CSc1cccc(Cl)c1)NC1CCNCC1.O=Cc1ccn(-c2ccc(C(F)(F)F)cc2)c1>>O=C(CSc1cccc(Cl)c1)NC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1,,CC(Cl)Cl,,O=C([O-])O.[Na+],,val
US20070015774A1,CC(C)COC(=O)[C@H](CCN(C)C)NC(=O)OC(C)(C)C.N>>CN(C)CC[C@H](NC(=O)OC(C)(C)C)C(N)=O,,CO,,,,val
US20160237090A1,CC(C)(C)OC(=O)N1CCn2ncc(I)c2C1.COCC1CCNC1>>COCC1CCN(c2cnn3c2CN(C(=O)OC(C)(C)C)CC3)C1,[Cu]I,CS(C)=O,O,O=C(O)[C@@H]1CCCN1,O=C([O-])[O-].[K+].[K+],val
US06372746B1,COc1ccnc(N2CCNCC2)n1.O=C(O)c1cc2ccccc2[nH]1>>COc1ccnc(N2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)n1,,O,,C1CCOC1,,val
USRE039591E1,O=C1c2ccccc2C(=O)N1O.OCc1ccnc2ccccc12>>O=C1c2ccccc2C(=O)N1OCc1ccnc2ccccc12,,C1CCOC1,CCOCC,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04305945,CSC(=N)N.NCCCCCO>>N=C(N)OCCCCCN,,C1CCOC1,,[H-].[Na+],,val
US03957782,CCOC(=O)c1nc2c(C)nn(CC)c2nc1OCC>>CCOc1nc2c(nc1C(=O)O)c(C)nn2CC,,CCO,,[Na+].[OH-],,val
US20100311966A1,COC(=O)c1ccc(CBr)cc1.O=[N+]([O-])c1ccc2c(c1)OCCN2>>COC(=O)c1ccc(CN2CCOc3cc([N+](=O)[O-])ccc32)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20020137769A1,ClC(c1ccccc1)(c1ccccc1)c1ccccc1.OCc1ncc[nH]1>>OCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,,CCN(CC)CC,,CN(C)C=O,Cl,val
US20160108050A1,COc1ccc(CN(c2nc(Nc3cc(C#N)cc(C(C)CCO)c3Cl)nn3c(C#N)cnc23)C2CC2)cc1>>COc1ccc(CN(c2nc(Nc3cc(C#N)cc(C(C)CC=O)c3Cl)nn3c(C#N)cnc23)C2CC2)cc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20020183320A1,Nc1nccs1.O=Cc1cccnc1.[C-]#[N+]c1c(C)cccc1C>>Cc1cccc(C)c1Nc1c(-c2cccnc2)nc2sccn12,,[O-][Cl+3]([O-])([O-])O,,,,val
US20100125062A1,Brc1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)cc1.CC1(C)OB(C2=CCOCC2)OC1(C)C>>C1=C(c2cccnc2Oc2ccc(Nc3nc4ccccc4[nH]3)cc2)CCOC1,,CC#N,O,CC(=O)[O-].[K+],,val
US20140315960A1,CC(C)Cc1ccc(C(C)C(=O)Cl)cc1.CN(C)c1ccc(CCO)cc1>>CC(C)c1ccc(C(C)C(=O)OCCc2ccc(N(C)C)cc2)cc1,,ClCCl,,c1ccncc1,,val
US05753664,Cn1ncc2[nH]ccc2c1=O.O=C(c1ccc(CBr)cc1)c1ccc(C(F)(F)F)cc1>>Cn1ncc2c(ccn2Cc2ccc(C(=O)c3ccc(C(F)(F)F)cc3)cc2)c1=O,,CN(C)C=O,,O,[H-].[Na+],val
US06197729B1,OC(c1ccc(OCc2ccccc2)cc1)C(F)(F)F>>Oc1ccc(C(O)C(F)(F)F)cc1,[Pd],CC(=O)O,,[H][H],,val
US20120277224A1,CCOC(=O)CC(=O)c1ccc(F)cc1F.Nc1n[nH]c(N)c1-c1ccccn1>>Nc1nn2c(=O)cc(-c3ccc(F)cc3F)[nH]c2c1-c1ccccn1,,CCCCO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150361029A1,CC(C)(C)[C@@H]1CC[C@H](O)CC1.Oc1cc(I)c2ccccc2c1>>CC(C)(C)[C@@H]1CC[C@@H](Oc2cc(I)c3ccccc3c2)CC1,,Cc1ccccc1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20050004164A1,Br[Mg]c1cccc2ccccc12.CCOC(=O)/C(C#N)=C/c1c(Cl)cccc1Cl>>CCOC(=O)C(C#N)C(c1c(Cl)cccc1Cl)c1cccc2ccccc12,,C1CCOC1,,,,val
US20050059687A1,BrBr.CCc1nc2ccccc2c(=O)[nH]1>>CC(Br)c1nc2ccccc2c(=O)[nH]1,,CC(=O)O,,O,,val
US05681940,CC(C)(C)[Si](C)(C)Cl.COc1ccc(C(c2ccccc2)(c2ccc(OC)cc2)C(O)[C@H]2O[C@@](C#N)(n3cc(C)c(=O)[nH]c3=O)C[C@@H]2O)cc1>>COc1ccc(C(c2ccccc2)(c2ccc(OC)cc2)C(O)[C@H]2O[C@@](C#N)(n3cc(C)c(=O)[nH]c3=O)C[C@@]2(O)[Si](C)(C)C(C)(C)C)cc1,,c1ccncc1,,c1c[nH]cn1,,val
US20020086891A1,OCC#Cc1ccc2c(-c3ccc(C(F)(F)F)cc3)nsc2c1>>OCCCc1ccc2c(-c3ccc(C(F)(F)F)cc3)nsc2c1,O=[Pt]=O,CO,,,,val
US04871872,CC(N)(Cc1ccc(F)cc1)c1ccc(F)cc1.O=C(O)CNC(=O)CNC(=O)OCc1ccccc1>>CC(Cc1ccc(F)cc1)(NC(=O)CNC(=O)CN)c1ccc(F)cc1,,ClC(Cl)Cl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20130336920A1,CN(CCN1CCOCC1)C(=O)c1cccc(C(=O)O)c1.Cl.Nc1ccc(N2CCCCC2)cc1-c1cc(C(=O)NCc2cccc(C(F)(F)F)c2)ccn1>>CN(CCN1CCOCC1)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1.Cl,CN(C)c1ccncc1,CCOC(C)=O,ClCCl,CCN=C=NCCCN(C)C,,val
US20100305096A1,BrP(Br)Br.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CO)sc2n1>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CBr)sc2n1,,ClCCl,,,,val
US20030130213A1,FF.NC(=O)c1nccnc1N>>NC(=O)c1nc(F)cnc1N,,O=C(O)C(F)(F)F,,CCOC(C)=O,O=C([O-])O.[Na+],val
US20110118271A1,CON(C)c1cc2c(cn1)CN(c1cc([N+](=O)[O-])c(F)cc1C)C(=O)N2C(C)C>>CNc1cc2c(cn1)CN(c1cc(N)c(F)cc1C)C(=O)N2C(C)C,[Pd],CO,,,,val
US20160229814A1,CCn1c(=O)[nH]c(=O)c2cc([N+](=O)[O-])ccc21.COCCBr>>CCn1c(=O)n(CCOC)c(=O)c2cc([N+](=O)[O-])ccc21,,CN(C)C=O,,O,[H-].[Na+],val
US20060199795A1,CC(C)(C)CN1C(=O)C(CC(=O)NCc2ccccc2F)N(C(=O)c2ccncc2)Cc2ccccc21.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)CN1C(=O)C(CC(=O)NCc2ccccc2F)N(C(=O)c2cc[n+]([O-])cc2)Cc2ccccc21,,ClC(Cl)Cl,,,,val
US20100137313A1,COc1cc(Nc2ncc(-c3cnc(OC)c(C#N)c3)c(-n3nc(C(F)(F)F)cc3C)n2)cc(OC)c1.NO>>COc1cc(Nc2ncc(-c3cnc(OC)c(/C(N)=N\O)c3)c(-n3nc(C(F)(F)F)cc3C)n2)cc(OC)c1,,CCO,,,,val
US20130116285A1,N#Cc1ccc(F)c(Br)c1.Oc1ccccc1>>N#Cc1ccc(Oc2ccccc2)c(Br)c1,,CCOC(C)=O,CS(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20040192686A1,COCCBr.Nc1nc2ccc(O)cc2[n+]([O-])n1>>COCCOc1ccc2nc(N)n[n+]([O-])c2c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110082133A1,CC(C)(C)OC(=O)c1ccc(CCn2c(CBr)c(Cl)cc(Cl)c2=O)cc1.c1ccc2c(c1)CCN2>>CC(C)(C)OC(=O)c1ccc(CCn2c(CN3CCc4ccccc43)c(Cl)cc(Cl)c2=O)cc1,,CN(C)C=O,O,CCOC(C)=O,CC(C)(C)[O-].[K+],val
US20050020652A1,CCCCOC(C)(Cc1ccc(OCCC2CN(Cc3cccc(C(F)(F)F)c3)C(=O)N2C)cc1)C(=O)OCC>>CCCCOC(C)(Cc1ccc(OCCC2CN(Cc3cccc(C(F)(F)F)c3)C(=O)N2C)cc1)C(=O)O,,CCO,,[Na+].[OH-],,val
US20160221994A1,CC(=O)Cl.Cc1cscc1C>>CC(=O)c1scc(C)c1C,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20090298823A1,CN(C(=O)C1CC1)c1ccc(N)cc1.Clc1nc(NC2CCC2)c2cc[nH]c2n1>>CN(C(=O)C1CC1)c1ccc(Nc2nc(NC3CCC3)c3cc[nH]c3n2)cc1,,CCCCO,,C[Si](C)(C)Cl,,val
US20060094739A1,C=CC(=O)Oc1ccc(Cl)cc1.O=Cc1cccnc1>>C=C(C(=O)Oc1ccc(Cl)cc1)C(O)c1cccnc1,,ClCCl,,C1CN2CCN1CC2,,val
US05677302,CCCCn1sc2nc3ccccc3n2c1=O.N#CC(=O)c1ccccc1>>O=C(c1ccccc1)c1nsc2nc3ccccc3n12,,ClCCl,,,,val
US04837319,O=S(Cl)Cl.O=c1c(CCc2ccccc2)nc2c(n1CCO)CCCC2>>O=c1c(CCc2ccccc2)nc2c(n1CCCl)CCCC2,,ClC(Cl)Cl,,O=C([O-])[O-].[K+].[K+],,val
US20080293708A1,CC(C)N1CCN(c2ccc(N)c3c2CN(C)C3=O)CC1.Clc1ncc(Cl)c(Cl)n1>>CC(C)N1CCN(c2ccc(Nc3nc(Cl)ncc3Cl)c3c2CN(C)C3=O)CC1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04965356,COc1ccc([C@H]2Cc3c(cccc3C(F)(F)F)NC(=O)[C@H]2O)cc1.O=C1OC(=O)c2ccccc21>>COc1ccc([C@H]2Cc3c(cccc3C(F)(F)F)NC(=O)[C@H]2OC(=O)c2ccccc2C(=O)O)cc1,CN(C)c1ccncc1,CCN(CC)CC,,ClCCl,,val
US20100261732A1,CC(=O)OC(C)=O.Cn1nc(CCN2CCN(c3cccc(N)c3)CC2)n(CC2CCCCC2)c1=O>>CC(=O)Nc1cccc(N2CCN(CCc3nn(C)c(=O)n3CC3CCCCC3)CC2)c1,,c1ccncc1,,Cc1ccccc1,,val
US04542158,CCOC(=O)OC(C)Cl.O=C(O)c1ccccc1O>>CCOC(=O)OC(C)OC(=O)c1ccccc1O,,Cc1ccccc1,O,CCN(CC)CC,CCOCC,val
US20150011461A1,Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(N=C(c2ccccc2)c2ccccc2)c1=O>>Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(N)c1=O,,C1COCCO1,Cl,,,val
US20120108568A1,CC(C)(C)OC(=O)N1[C@@H](c2cncc(F)c2)CC[C@@]1(C)CO.Cl>>C[C@@]1(CO)CC[C@H](c2cncc(F)c2)N1.Cl,,ClCCl,,C1COCCO1,,val
US20050085541A1,COc1c(Oc2c(C)cc(N(Cc3ccccc3)Cc3ccccc3)c3c2CCC3)ccc(OCc2ccccc2)c1C(C)=O.[Li]C>>COc1c(Oc2c(C)cc(N(Cc3ccccc3)Cc3ccccc3)c3c2CCC3)ccc(OCc2ccccc2)c1C(C)(C)O,,C1CCOC1,CCOCC,[Cl-].[NH4+],,val
US20010007873A1,CN(C)CCCl.Nc1cccc(-c2ccc(O)cc2C2CCCC2)n1>>CN(C)CCOc1ccc(-c2cccc(N)n2)c(C2CCCC2)c1,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05039806,CCCCCCCOc1c(C)cc2[nH]c(SCc3ncc(C)c(OC)c3C)nc2c1C.O=C(OO)c1cccc(Cl)c1>>CCCCCCCOc1c(C)cc2[nH]c(S(=O)Cc3ncc(C)c(OC)c3C)nc2c1C,,ClCCl,O,[Na+].[OH-],,val
US20040209862A1,CCN(CC)C(=S)Cl.Oc1cc(Br)cc(Br)c1>>CCN(CC)C(=S)Oc1cc(Br)cc(Br)c1,,CN1CCCC1=O,,[H-].[Na+],,val
US20140256819A1,Nc1cccc(I)c1.O=C=Nc1cc(C(F)(F)F)ccc1F>>O=C(Nc1cccc(I)c1)Nc1cc(C(F)(F)F)ccc1F,,ClCCCl,,,,val
US20150158857A1,CC(C)(C)OC(=O)N[C@@H](c1ccccc1)c1cccc(OCc2nc(C(=O)O)co2)c1.COc1ccc([C@@H](O)Cc2c(Cl)c[n+]([O-])cc2Cl)cc1OC>>COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)c2coc(COc3cccc([C@@H](NC(=O)OC(C)(C)C)c4ccccc4)c3)n2)cc1OC,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US06495547B1,O=C(O)C1CCc2ccccc2O1>>O=C(O)[C@H]1CCc2ccccc2O1,,CCO,,,,val
US05547972,CCC(C#N)(CC)c1ccc(Cl)cc1.O>>CCC(CC)(C(N)=O)c1ccc(Cl)cc1,,CCCCCO,,[K+].[OH-],,val
US20130203776A1,O=C(NCCCCl)c1cnn2ccc(N3C(=O)OC[C@@H]3c3cc(F)c[nH]c3=O)nc12>>O=C1NCCCOc2ncc(F)cc2[C@H]2COC(=O)N2c2ccn3ncc1c3n2,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20160158207A1,CC1CCNc2ccccc21.O=C1CCC(=O)N1Br>>CC1CCNc2ccc(Br)cc21,,ClCCl,,,,val
US20120329785A1,COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Nc1cccc(S(N)(=O)=O)c1>>COc1ccc2nc(Nc3cccc(S(N)(=O)=O)c3)c3n[nH]cc3c2c1,C1COCCO1,CO,,Cl,,val
US04935431,CCCC(=O)C(=CNc1cscc1OC)C(=O)OCC>>CCCC(=O)c1c[nH]c2c(OC)csc2c1=O,,c1ccc(Oc2ccccc2)cc1,,,,val
US20090291977A1,Cc1nc2c(N)cc(C(=O)OC(C)C)cn2c1C.ClC1CCOc2ccccc21>>Cc1nc2c(NC3CCOc4ccccc43)cc(C(=O)OC(C)C)cn2c1C,,CC(C)=O,,[I-].[K+],O=C([O-])O.[Na+],val
US20030236297A1,CC(=O)NC(C[C@@H](C)COC(C)=O)c1cccs1.O=C1CCC(=O)N1Br>>CC(=O)NC(C[C@@H](C)COC(C)=O)c1ccc(Br)s1,,CN(C)C=O,,O,,val
US20100190775A1,NN.O=C(O)c1ccccc1I>>NNC(=O)c1ccccc1I,,ClCCl,,O,O=C(n1ccnc1)n1ccnc1,val
US20120088755A1,COc1ccc2c(c1)CCN(C1CCNCC1)C(=O)N2.Cc1cc(Oc2cc(Cl)ncn2)cc2[nH]c(C3CC3)nc12>>COc1ccc2c(c1)CCN(C1CCN(c3cc(Oc4cc(C)c5nc(C6CC6)[nH]c5c4)ncn3)CC1)C(=O)N2,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20030087891A1,CCOB(OCC)OCC.CCc1cc(Br)c(OC)cc1OCc1ccccc1>>CCc1cc(B(O)O)c(OC)cc1OCc1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20070082912A1,COc1ccc(CCl)cc1.CS(=O)(=O)c1ccc(O)c(C=O)c1>>COc1ccc(COc2ccc(S(C)(=O)=O)cc2C=O)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20030199689A1,CCOC(=O)c1cc2ccccc2n1CCc1ccc(Cl)cc1>>O=C(O)c1cc2ccccc2n1CCc1ccc(Cl)cc1,,C1COCCO1,O,Cl,[Na+].[OH-],val
US20090253687A1,BrBr.CCOC(=O)c1ccc(O)c([N+](=O)[O-])c1>>CCOC(=O)c1cc(Br)c(O)c([N+](=O)[O-])c1,,O,,CC(=O)O,,val
US05610142,COC(=O)CN1CN(c2ccccc2)C2(CCN(C(=O)OC(C)(C)C)CC2)C1=O>>CC(C)(C)OC(=O)N1CCC2(CC1)C(=O)N(CC(=O)O)CN2c1ccccc1,,O,,CO,O=C([O-])[O-].[K+].[K+],val
US20100056521A1,CCOC(=O)c1ccc(F)cc1OCOC.N#Cc1c[nH]c2cc(F)c(F)cc12>>CCOC(=O)c1ccc(-n2cc(C#N)c3cc(F)c(F)cc32)cc1OCOC,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110118245A1,CCOC(=O)Cn1nc(C(C)(C)C)cc1NC(=O)Oc1ccccc1.COc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC>>CCOC(=O)Cn1nc(C(C)(C)C)cc1NC(=O)Nc1cccc(Oc2ncnc3cc(OC)c(OC)cc23)c1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US05449783,Nc1nc(-c2ccccc2)c(-c2ccccc2)s1.O=S(=O)(Cl)CCl>>O=S(=O)(CCl)Nc1nc(-c2ccccc2)c(-c2ccccc2)s1,,c1ccncc1,,,,val
US04182758,CCOC(=O)ON(CC(CP(=O)(OCC)OCC)OC1CCCCO1)C(=O)OCC>>CCOC(=O)ON(CC(O)CP(=O)(OCC)OCC)C(=O)OCC,,CCO,,Cl,,val
US20100120844A1,CC(C)S(=O)(=O)Nc1cccc(CN(CCN2Cc3ccc(F)cc3CC2Cc2ccc(F)cc2)C(=O)OC(C)(C)C)c1.CI>>CC(C)S(=O)(=O)N(C)c1cccc(CNCCN2Cc3ccc(F)cc3CC2Cc2ccc(F)cc2)c1,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US05238790,ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccccc1-c1ccccc1C(=O)O>>O=C(Cl)c1ccccc1-c1ccccc1C(=O)Cl,,CN(C)C=O,,,,val
US20020161001A1,Cn1c(=O)c2c(nc(Cl)n2Cc2ccccc2)n(C)c1=O.OCC1CNCCNC1>>Cn1c(=O)c2c(nc(N3CCNCC(CO)C3)n2Cc2ccccc2)n(C)c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20070244125A1,CC(C)(C)[Si](C)(C)OCCn1c(C(=O)N2CCC(F)(F)CC2)cc2cc(C(=O)N3CCC[C@H]3CN3CCCC3)ccc21>>O=C(c1cc2cc(C(=O)N3CCC[C@H]3CN3CCCC3)ccc2n1CCO)N1CCC(F)(F)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20160095844A1,BrC1COC1.CC1(C)C(=O)Nc2cc(Br)ccc21>>CC1(C)C(=O)N(C2COC2)c2cc(Br)ccc21,,CN(C)C=O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20140350034A1,Cc1cc(NC(=O)OC(C)(C)C)nc(C)c1CNc1ncnc2oc(Cc3c(Cl)cccc3Cl)nc12>>Cc1cc(N)nc(C)c1CNc1ncnc2oc(Cc3c(Cl)cccc3Cl)nc12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100069388A1,CCOC(=O)c1cc(F)c(N[C@@H](C(=O)NCC2CCCCC2)C(C)C)nc1Cl>>CCOC(=O)c1cnc(N[C@@H](C(=O)NCC2CCCCC2)C(C)C)c(F)c1,[Pd],CCO,,O=C[O-].[NH4+],,val
US20130196974A1,Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(CCC#N)c2c1.O>>Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(CCC(N)=O)c2c1,,CC(C)(C)O,O,[K+].[OH-],,val
US20030073849A1,CN(C)C=Cc1ccc(C#N)cc1[N+](=O)[O-]>>N#Cc1ccc2cc[nH]c2c1,[Pd],CO,,,,val
US20130310379A1,CN(C(=O)c1ccc(Oc2ccccc2)cc1)C1CCN(C(=O)[O-])CC1.O=C(O)C(F)(F)F>>CN(C(=O)c1ccc(Oc2ccccc2)cc1)C1CCNCC1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4cc(F)cc(F)c4)nc(Cl)c3n2)cc1.COc1ccc(N)cc1OC>>COc1ccc(Nc2nc(-c3cc(F)cc(F)c3)nc3cn[nH]c23)cc1OC,C1COCCO1,CO,,Cl,,val
US05604213,CC(=O)Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12>>C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC=C2c1cccnc1,,CO,,[Na+].[OH-],,val
US20070135479A1,COC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.COc1cccc(C(C)=O)c1>>COC(=O)C=C(C)c1cccc(OC)c1,,Cc1ccccc1,,,,val
US05360822,CS(=O)(=O)Nc1ccc(F)c(C(=O)O)c1.C[N+](=O)[O-]>>CS(=O)(=O)Nc1ccc(F)c(C(=O)C[N+](=O)[O-])c1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20070032531A1,CCCC(=O)Oc1ccc(CC(=O)Nc2nc(-c3ccc(Cl)cc3)cs2)cc1[N+](=O)[O-]>>CCCC(=O)Oc1ccc(CC(=O)Nc2nc(-c3ccc(Cl)cc3)cs2)cc1N,[Pd],CCO,,[H][H],,val
US03963745,COc1ccc(S(N)(=O)=O)cc1C(=O)O.NC1CCN(C2CCCCC2)C1>>COc1ccc(S(N)(=O)=O)cc1C(=O)NC1CCN(C2CCCCC2)C1,,c1ccncc1,,ClP(Cl)Cl,,val
US20110251184A1,CCOC(=O)c1cc2n(n1)CCCNC2.O=C(O)c1ccc(-c2ccccn2)s1>>CCOC(=O)c1cc2n(n1)CCCN(C(=O)c1ccc(-c3ccccn3)s1)C2,,ClCCl,,CN1CCOCC1,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US06147031,COC(=O)c1ccc(S(C)(=O)=O)c(-c2ccon2)c1C>>Cc1c(C(=O)O)ccc(S(C)(=O)=O)c1-c1ccon1,,CCO,,Cl,[Na+].[OH-],val
US20100317623A1,C=CCC(C)(C)COC(=O)N[C@H](C(=O)N1C[C@H](Oc2nccc3cc(OC)c(Br)cc23)C[C@H]1C(=O)OCC)C1CCCCC1.CCCCC([Sn])=C(CCCC)CCCC>>C=CCC(C)(C)COC(=O)N[C@H](C(=O)N1C[C@H](Oc2nccc3cc(OC)c(C=C)cc23)C[C@H]1C(=O)OCC)C1CCCCC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20150038528A1,CC(C)(C)OC(=O)C1(C#N)CCSCC1.O>>CC(C)(C)OC(=O)C1(C#N)CCS(=O)CC1,,CCOC(C)=O,,CC#N,,val
US05990142,CCOC(=O)c1cc(=O)c2cccc(NC(=O)c3ccc4c(c3)CCC(COCc3ccccc3)O4)c2o1>>O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2c(c1)CCC(COCc1ccccc1)O2,,C1CCOC1,CO,[Na+].[OH-],,val
US20120277224A1,CCOC=O.N#CCc1cccc(Cl)c1>>N#CC(C=O)c1cccc(Cl)c1,,CCO,,,,val
US20120329780A1,COc1ccc(Cn2cc3nc(-c4ccncc4)nc(Cl)c3n2)cc1.Nc1cc[nH]n1>>c1cc(-c2nc(Nc3cc[nH]n3)c3[nH]ncc3n2)ccn1,C1COCCO1,CO,,Cl,,val
US20020150885A1,CCCCCCNC.O=C(Cl)Cl>>CCCCCCN(C)C(=O)Cl,,CCOCC,,CCN(C(C)C)C(C)C,,val
US20020115674A1,COc1ccc(-n2c(=O)n(OCc3ccccc3)c(=O)c3cc(F)c(N4CCC(NC(=O)OC(C)(C)C)C4)cc32)cc1>>COc1ccc(-n2c(=O)n(O)c(=O)c3cc(F)c(N4CCC(NC(=O)OC(C)(C)C)C4)cc32)cc1,[Pd],,,,,val
US20160016908A1,C/C=C/NC(=O)OCc1ccccc1.N#Cc1ccc(N)cc1.O=CC1CC1>>C[C@@H]1[C@@H](NC(=O)OCc2ccccc2)c2cc(C#N)ccc2N[C@H]1C1CC1,,ClCCl,,,,val
US05530186,CCCCCCCCCCCCCCCC[NH-].O=C(CI)OC(=O)CI>>CCCCCCCCCCCCCCCCNC(=O)CI,,ClCCl,,,,val
US20100292235A1,Nc1cccc2c(=O)n(Cc3ccc(C(F)(F)F)nc3)ccc12.O=C(O)Cc1ccc(Cl)c(C(F)(F)F)c1>>O=C(Cc1ccc(Cl)c(C(F)(F)F)c1)Nc1cccc2c(=O)n(Cc3ccc(C(F)(F)F)nc3)ccc12,,O=S(Cl)Cl,,CCN(C(C)C)C(C)C,CO,val
US20150232435A1,CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.O=C(n1ccnc1)n1ccnc1.c1ccc(N2CCNCC2)nc1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCN(c4ccccn4)CC3)CC2)cc(C(F)(F)F)n1,,CO,ClC(Cl)Cl,,,val
US20160106754A1,CC1(C)CC(=O)CC(=O)N1.Nc1ncc(Br)nc1S>>CC1(C)CC2=C(Sc3nc(Br)cnc3N2)C(=O)N1,CCN(CC)CC,CCO,,,,val
US20040058942A1,CCCCCCCCCCCCCCCc1cccc(OCC)c1C=O.CCOC(=O)CC(C)=O.NC(N)=O>>CCCCCCCCCCCCCCCc1cccc(OCC)c1C1NC(=O)NC(C)=C1C(=O)OCC,,C1CCOC1,,Cl,,val
US20050085512A1,CC(C)(C)c1ccc(N)cc1.N#Cc1ccc(C(=O)Cl)cc1>>CC(C)(C)c1ccc(NC(=O)c2ccc(C#N)cc2)cc1,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US20080167314A1,Cc1ccc(C(=O)Cl)cc1.Cc1cccc(-c2nc3cccnn3c2-c2ccnc(N)c2)c1>>Cc1ccc(C(=O)Nc2cc(-c3c(-c4cccc(C)c4)nc4cccnn34)ccn2)cc1,,C1CCOC1,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20160009701A1,COC(=O)c1cc(-c2c(C)noc2C)cc2c1[nH]c1ccc(OC)cc12>>COc1ccc2[nH]c3c(C(=O)O)cc(-c4c(C)noc4C)cc3c2c1,,C1CCOC1,O,[Li+].[OH-],,val
US20100249099A1,C1CC2CNCC1O2.COc1cccc2c1nc(C(F)F)n2-c1nc(Cl)nc(N2CCN(C(=O)OC(C)(C)C)CC2)n1>>COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCN(C(=O)OC(C)(C)C)CC2)nc(N2CC3CCC(C2)O3)n1,,C1CCOC1,,CCN(C(C)C)C(C)C,Cl,val
US04766127,CC1(c2ccc3cc(Br)ccc3c2)OCCO1.O=Cc1cccnc1>>CC1(c2ccc3cc(C(O)c4cccnc4)ccc3c2)OCCO1,,C1CCOC1,,[Li]C(C)(C)C,,val
US20070173508A1,Nc1ccc2cc(I)ccc2n1.O=CCCl>>Ic1ccc2c(ccc3nccn32)c1,,C1COCCO1,,O=C([O-])O.[Na+],,val
US20110230518A1,Brc1ccc2[nH]ccc2c1.CI.CN(C)C=O>>Cn1ccc2cc(C#N)ccc21,,CN(C)C=O,,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US08288411B2,CC(C)(C)OC(=O)NC[C@@H]1CCCCN1.O=C(O)c1nc(Br)sc1-c1ccc(F)cc1>>CC(C)(C)OC(=O)NC[C@@H]1CCCCN1C(=O)c1nc(Br)sc1-c1ccc(F)cc1,,CC#N,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20110021489A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C1CNCC(c2ccc(OC(F)(F)F)c(F)c2)C1>>COC(=O)C1CC(c2ccc(OC(F)(F)F)c(F)c2)CN(C(=O)OC(C)(C)C)C1,,ClCCl,,CCN(CC)CC,,val
US20100317865A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)[C@@](C)(CCCOc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)OC(C)(C)C>>C[C@](N)(CCCOc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20060052384A1,CCC(=O)c1ccc(Br)cc1.N#C[Cu]>>CCC(=O)c1ccc(C#N)cc1,,CN(C)C=O,,Cl,O,val
US05206240,CS(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN(CCc3ccc4nonc4c3)CC1)O2.Cl>>CS(=O)(=O)Nc1ccc2c(c1)C(O)CC1(CCN(CCc3ccc4nonc4c3)CC1)O2.Cl,,CCO,CCOC(C)=O,[BH4-].[Na+],,val
US20150025075A1,Clc1cc(Cl)c(CBr)c(Br)c1.O=C1NC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1Cc1c(Cl)cc(Cl)cc1Br,,CC#N,,O=C([O-])[O-].[K+].[K+],O=C([O-])O.[Na+],val
US20160002269A1,COC(=O)c1ccc(C#Cc2ccccc2)cc1O>>O=C(O)c1ccc(C#Cc2ccccc2)cc1O,,C1COCCO1,O,CCOC(C)=O,[Na+].[OH-],val
US20090270417A1,COCCCOc1cc(O[C@@H](C(=O)OCc2ccccc2)C(C)C)ccc1OC>>COCCCOc1cc(O[C@@H](CO)C(C)C)ccc1OC,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US06248756B1,COC(=O)C1CCN(C(=O)OC(C)(C)C)CC1.Cc1cccc(C(=O)Cl)c1>>COC(=O)C1(C(=O)c2cccc(C)c2)CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,CCOC(C)=O,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US05225402,COC(=O)c1ccc(N2C(=O)CCc3ccccc32)cc1>>O=C(O)c1ccc(N2C(=O)CCc3ccccc32)cc1,,CO,,[Na+].[OH-],,val
US20090227575A1,Clc1nc(N2CCOCC2)c2ccc3c(ccn3Cc3ccccc3)c2n1.OB(O)c1cccc(O)c1>>Oc1cccc(-c2nc(N3CCOCC3)c3ccc4c(ccn4Cc4ccccc4)c3n2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US20050227959A1,CN(CC(O)c1ccc(F)cc1)S(=O)(=O)c1csc(Cl)c1.COCCl>>COCOC(CN(C)S(=O)(=O)c1csc(Cl)c1)c1ccc(F)cc1,,CCOC(C)=O,ClCCl,CCN(C(C)C)C(C)C,[I-].[Na+],val
US20110086834A1,C1COCCN1.O=[N+]([O-])c1cc(I)ccc1CBr>>O=[N+]([O-])c1cc(I)ccc1CN1CCOCC1,,O,,C1CCOC1,,val
US20090163490A1,CN1CCNCC1.CSc1nc(-c2ccc(F)cc2C)c2c(C#N)cn(COCC[Si](C)(C)C)c2n1>>Cc1cc(F)ccc1-c1nc(N2CCN(C)CC2)nc2c1c(C#N)cn2COCC[Si](C)(C)C,,CN(C)C=O,,,,val
US20080200454A1,CS(=O)(=O)N1CCc2c(c(-c3ccc(Cl)c(C#Cc4ccc5[nH]ccc5c4)c3)nn2CCCN2CCOCC2)C1>>CS(=O)(=O)N1CCc2c(c(-c3ccc(Cl)c(CCc4ccc5[nH]ccc5c4)c3)nn2CCCN2CCOCC2)C1,O=[Pt]=O,CCO,CCOC(C)=O,,,val
US20050020684A1,CCOC(=O)[C@H](Cc1ccc(OCCCOc2ccc(I)cc2)cc1)OC.OB(O)c1ccc2[nH]ccc2c1>>CCOC(=O)[C@H](Cc1ccc(OCCCOc2ccc(-c3ccc4[nH]ccc4c3)cc2)cc1)OC,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05380461,CCCc1ccc(I)cc1.FC(F)=C(F)F>>CCCc1ccc(C(F)=C(F)F)cc1,,CCCCCC,CCOCC,Cl,[Li]CCCC,val
US20070249670A1,COC(=O)[C@@H](NC(=O)c1ccc(Cl)cc1N)C1CCCCC1.O=C=Nc1c(Cl)cc(Cl)cc1Cl>>COC(=O)[C@@H](NC(=O)c1ccc(Cl)cc1NC(=O)Nc1c(Cl)cc(Cl)cc1Cl)C1CCCCC1,,c1ccncc1,,,,val
US20140357642A1,CCOC(=O)CCCCCCN1CCCc2nc(-c3ccc(C)nc3)c(-c3ccc(C)nc3)nc21>>Cc1ccc(-c2nc3c(nc2-c2ccc(C)nc2)N(CCCCCCC(=O)O)CCC3)cn1,,CO,,[Na+].[OH-],,val
US04363816,Cc1c(N)c(C(=O)[O-])n(C)c1C.O=[N+]([O-])c1ccccc1Cl.[K+]>>Cc1c(Nc2ccccc2[N+](=O)[O-])c(C(=O)[O-])n(C)c1C.[K+],,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20120289522A1,Cc1noc(-c2ccc(Br)cc2)c1CN=[N+]=[N-]>>Cc1noc(-c2ccc(Br)cc2)c1CN,,C1CCOC1,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20140045819A1,C=CC(=O)OCC.Nc1cccc(Cl)c1I>>O=C1CCc2c(Cl)cccc2N1,,CS(C)=O,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US20070244125A1,CCOC(=O)c1cc2cc(C(=O)O)ccc2[nH]1.CN(C)C1CCNC1>>CCOC(=O)c1cc2cc(C(=O)N3CCC(N(C)C)C3)ccc2[nH]1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20160016935A1,COc1ccnc(F)c1.C[C@@H]1CC[C@@H](O)CN1C(=O)OC(C)(C)C>>COc1ccnc(O[C@@H]2CC[C@@H](C)N(C(=O)OC(C)(C)C)C2)c1,,CN(C)C=O,CS(C)=O,[H-].[Na+],,val
US20090275523A1,CC(C)(C)OC(=O)N1CCC2(CCNCC2)CC1.CCCC=O>>CCCCN1CCC2(CC1)CCN(C(=O)OC(C)(C)C)CC2,,ClCCl,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US05273975,COC(=O)n1c(Cl)nc2c(C)cccc21.O=C1CCC(=O)N1Br>>COC(=O)n1c(Cl)nc2c(CBr)cccc21,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20120108565A1,CC1(C)OC(=O)C(=C(O)c2ccc(C#N)cc2)C(=O)O1.CCO>>CCOC(=O)CC(=O)c1ccc(C#N)cc1,,CCO,,,,val
US20050233245A1,CC(C)c1cc(C(C)C)c(S(=O)(=O)Cl)c(C(C)C)c1.O>>CC(C)c1cc(C(C)C)c(S(=O)(=O)O)c(C(C)C)c1,,CS(C)=O,O,,,val
US06713649B1,O.O=CO.O=COCc1ccccc1>>O.O=CO.O=COCc1ccccc1,,O=CO,,,,val
US20150225396A1,Clc1ccc(-c2nnc(C3CCNCC3)o2)cc1.O=C(O)CCCc1nc2ccccc2c(=O)[nH]1>>O=C(CCCc1nc2ccccc2c(=O)[nH]1)N1CCC(c2nnc(-c3ccc(Cl)cc3)o2)CC1,,O,,O=C(O)C(F)(F)F,,val
US20090143385A1,CCOC(=O)c1nnc2ccc(Cl)nn12.Cc1onc(-c2ccccc2)c1CO>>CCOC(=O)c1nnc2ccc(OCc3c(-c4ccccc4)noc3C)nn12,,CN(C)C=O,,[H-].[Na+],,val
US20080227826A1,CC(=O)O[C@H]1CCN(c2ccc(C(=O)Nc3ccccc3N)cc2)C1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(N2CC[C@H](O)C2)cc1,,C1CCOC1,CO,,,val
US05319100,CC(C)(C)c1cc(C=C2OCNC2=O)cc(C(C)(C)C)c1O.O=C=NS(=O)(=O)Cl>>CC(C)(C)c1cc(C=C2OCN(C(N)=O)C2=O)cc(C(C)(C)C)c1O,,Cc1ccccc1,,,,val
US20140107149A1,CC(C)(C)OC(=O)NCC(=O)NCC(F)F.Cl>>Cl.NCC(=O)NCC(F)F,,CCOC(C)=O,,,,val
US20120178744A1,CCOC(=O)CC1CCC(c2cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3ncc(-c4ccc(Cl)nc4)c3n2)CC1.OB(O)c1ccccc1>>CCOC(=O)CC1CCC(c2cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3ncc(-c4ccc(-c5ccccc5)nc4)c3n2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20050054683A1,CC(=O)NC[C@H]1CN(c2ccc(C3CCNCC3)c(F)c2)C(=O)O1.COC(=O)Cl>>COC(=O)N1CCC(c2ccc(N3C[C@H](CNC(C)=O)OC3=O)cc2F)CC1,,C1CCOC1,CCOC(C)=O,O=C([O-])O.[Na+],,val
US20080015246A1,CCOC(=O)c1ccc(-c2ccc(OCCCO)c(-c3ccc(N(CC)CC)c(CC)c3)c2)cc1>>CCc1cc(-c2cc(-c3ccc(C(=O)O)cc3)ccc2OCCCO)ccc1N(CC)CC,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20060100431A1,CS(=O)(=O)Cl.O=C(c1ccccc1)N1CC=C[C@H]1CO>>CS(=O)(=O)OC[C@@H]1C=CCN1C(=O)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US05393758,CC1(NC(=O)C(F)(F)F)CNC1.CCN(CC)CC.O=C(O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O>>CN(C(=O)C(F)(F)F)C1(C)CN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C1,,c1ccncc1,,Cl,,val
US05811433,CCOC(=O)C(=CNC1CC1)C(=O)c1c(C)nc(Cl)c(Cl)c1Cl>>CCOC(=O)c1cn(C2CC2)c2c(Cl)c(Cl)nc(C)c2c1=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050096336A1,COC(=O)C(Cc1cc(OCCc2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)c2ccccc2c1)OC>>COC(Cc1cc(OCCc2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)c2ccccc2c1)C(=O)O,,C1CCOC1,CO,[Li+].[OH-],,val
US20110098324A1,CCCCN.CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(CC2CCCCC2)c1=O>>CCCCNC(=O)c1c(O)c(C(=O)NCC(=O)O)c(=O)n(CC2CCCCC2)c1O,,ClC(Cl)Cl,,,,val
US20070213371A1,CC(=O)Cl.COC(c1ccc(C(F)(F)F)cc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCCCC1>>COC(c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(C)=O)C1CCCCC1,,ClCCl,,c1ccncc1,,val
US06517836B1,C1CN1.O=C(NCCn1ccnc1)c1cc(Cl)c([N+](=O)[O-])cc1[N+](=O)[O-]>>O=C(NCCn1ccnc1)c1cc(N2CC2)c([N+](=O)[O-])cc1[N+](=O)[O-],,C1CCOC1,,,,val
US20050272784A1,O=C(CCl)NC(=O)c1ccc(-c2ccccc2)cc1>>O=C1COC(c2ccc(-c3ccccc3)cc2)=N1,,COCCOC,,[H-].[Na+],,val
US03941853,Cc1c([N+](=O)[O-])cc([N+](=O)[O-])cc1[N+](=O)[O-].O=[N+]([O-])c1cc([N+](=O)[O-])c(C=Cc2c([N+](=O)[O-])cc([N+](=O)[O-])c(Cl)c2[N+](=O)[O-])c([N+](=O)[O-])c1>>O=[N+]([O-])c1cc([N+](=O)[O-])c(C=Cc2c([N+](=O)[O-])cc([N+](=O)[O-])c(Cc3c([N+](=O)[O-])cc([N+](=O)[O-])cc3[N+](=O)[O-])c2[N+](=O)[O-])c([N+](=O)[O-])c1,,CO,,CC#N,,val
US05068325,CC(=Cc1ccccc1)CCl.Nc1nc2c(s1)CCNCC2>>CC(=Cc1ccccc1)CN1CCc2nc(N)sc2CC1,,ClC(Cl)Cl,,,,val
US07642276B2,BrCc1noc2cc(Br)ccc12.NC(CO)CO>>OCC(CO)NCc1noc2cc(Br)ccc12,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20070275954A1,C[Si](C)(C)CCOCn1ccc(CO)n1>>C[Si](C)(C)CCOCn1ccc(C=O)n1,O=[Mn]=O,C1CCOC1,,,,val
US04082535,CCN.Clc1cc(NC2CC2)nc(Cl)n1>>CCNc1nc(Cl)cc(NC2CC2)n1,,CCO,,,,val
US20050261348A1,CC(=O)O.Clc1cc(N2CC3CNC3C2)cnc1Cl>>CC(=O)O.Clc1cc(N2C[C@@H]3CN[C@@H]3C2)cnc1Cl,,C1CCOC1,,N,O,val
US20130045964A1,CCOC(=O)C(O)c1ccc(-c2noc(-c3cnn(-c4ccccc4)c3C(F)(F)F)n2)cc1>>O=C(O)C(O)c1ccc(-c2noc(-c3cnn(-c4ccccc4)c3C(F)(F)F)n2)cc1,,C1CCOC1,,CO,[Li+].[OH-],val
US20030166639A1,CCOc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccc(CC)nc3)c2)cc1C(F)(F)F>>CCOc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3ccc(CC)nc3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US04820715,CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1O.O=C(CCl)c1ccccc1>>CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(=O)c1ccccc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20120244110A1,CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCc2c(ccc(Cl)[n+]2[O-])C1>>CC(=O)OC1CN(C(=O)OC(C)(C)C)Cc2ccc(Cl)nc21,,ClCCl,,,,val
US20060094588A1,COS(=O)(=O)OC.O=Cc1nc2c(-c3ccccc3)ccc(-c3ccccc3)c2[nH]1>>Cn1c(C=O)nc2c(-c3ccccc3)ccc(-c3ccccc3)c21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20100222389A1,C#CC1CC1.CC(Cc1sc(Br)cc1Cl)NC(=O)c1cn(C)nc1C(F)F>>CC(Cc1sc(C#CC2CC2)cc1Cl)NC(=O)c1cn(C)nc1C(F)F,[Cu]I,O,,CCN(CC)CC,CCOC(C)=O,val
US20160229810A1,C#CCOCCCCO.O=Cc1ccc(O)cc1>>C#CCOCCCCOc1ccc(C=O)cc1,,C1COCCO1,ClCCl,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120276018A1,O=C(CCl)c1cccs1.O=C(OC(c1ccccc1)c1ccc(F)c(F)c1)C1CN2CCC1CC2>>O=C(C[N+]12CCC(CC1)C(C(=O)OC(c1ccccc1)c1ccc(F)c(F)c1)C2)c1cccs1.[Cl-],,CCOC(C)=O,,,,val
US20100216814A1,CC(C)(C)C(=CBr)c1ccncc1.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3>>Cc1ccc2c(c1)c1c(n2/C=C(/c2ccncc2)C(C)(C)C)CCN(C)C1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20030008874A1,COc1ccc(Cl)cc1C(CC(=O)O)C(=O)O.NCc1ccccc1>>COc1ccc(Cl)cc1C1CCN(Cc2ccccc2)C1,,Cc1ccccc1C,,O,,val
US20100324068A1,CCOC(=O)C1CCN(C(=O)Cc2ccc(-c3ccc(-c4nc(C(N)=O)c(C)nc4C)cc3)c(Cl)c2)CC1>>Cc1nc(C)c(-c2ccc(-c3ccc(CC(=O)N4CCC(C(=O)O)CC4)cc3Cl)cc2)nc1C(N)=O,,CC(C)(C)O,,[K+].[OH-],,val
US20050227987A1,Nc1ccc2c(c1)CCC2=O.O=C(Cl)c1ccc(-c2ccccc2)cc1>>O=C(Nc1ccc2c(c1)CCC2=O)c1ccc(-c2ccccc2)cc1,,C1CCOC1,,CCN(CC)CC,,val
US20090215758A1,CC(C)(C)c1ccc(N)cc1.N.S=C(n1ccnc1)n1ccnc1>>CC(C)(C)c1ccc(NC(N)=S)cc1,,C1CCOC1,CO,,,val
US20040132727A1,CCN(CC)CCN.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCN(CC)CCNC(=O)Nc1cc(C)c(Oc2ccnc3cc(OC)c(OC)cc23)cc1C,,ClC(Cl)Cl,O,CCN(CC)CC,,val
US04536503,OCCCCCCCCCl.Oc1ccc2ccccc2c1>>OCCCCCCCCOc1ccc2ccccc2c1,,CCOCC,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090253687A1,Nn1cnnc1S.O=C1COc2ccc(C(=O)C(Br)c3ccccc3)cc2N1>>O=C1COc2ccc(C3=Nn4cnnc4SC3c3ccccc3)cc2N1,,CCO,Cc1ccccc1,,,val
US05736534,COc1ccc2ncnc(Cl)c2c1.c1ccc2c(c1)CCCN2>>COc1ccc2ncnc(N3CCCc4ccccc43)c2c1,,CCO,,,,val
US04299821,CC(C)(C)OC[C@H](NC(=O)[C@@H]1CCC(=O)N1C(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O>>CC(C)(C)OC[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(N)=O,[Pd],CO,,,,val
US20060111375A1,CC[Mg]Br.COc1cc2nccc(Oc3c(F)cccc3C=O)c2cc1OC>>CCC(O)c1cccc(F)c1Oc1ccnc2cc(OC)c(OC)cc12,,C1CCOC1,,O,,val
US20140288045A1,CC(C)(C)OC(=O)N1CCNCC1.COc1cc(Cl)c(I)cc1NCC(=O)O>>COc1cc(Cl)c(I)cc1NCC(=O)N1CCN(C(=O)OC(C)(C)C)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US05922882,C=O.CCNCC.OCCc1ccc(O)c(-n2nc3ccccc3n2)c1>>CCN(CC)Cc1cc(CCO)cc(-n2nc3ccccc3n2)c1O,,CCCCO,,,,val
US20040235919A1,CC(C)c1cnc(N)s1.C[C@H](C(=O)O)c1ccc(NC(=O)OC(C)(C)C)cc1>>CC(C)c1cnc(NC(=O)[C@@H](C)c2ccc(N)cc2)s1,,C1CCOC1,,CCN(CC)CC,O=S(Cl)Cl,val
US20140066627A1,Brc1ccc(I)cn1.CC1(C)OB(c2ccc(-c3nc4ccccc4n3-c3ccccc3)nc2)OC1(C)C>>Brc1ccc(-c2ccc(-c3nc4ccccc4n3-c3ccccc3)nc2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US06300352B1,CNC(=O)Cc1cccc(Br)c1.C[C@H](Oc1ccc(B(O)O)cc1)[C@@H](CCc1cccnc1)O[Si](C)(C)C(C)(C)C>>CNC(=O)Cc1ccc(-c2ccc(O[C@@H](C)[C@H](O)CCc3cccnc3)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],,val
US20130131035A1,Br.[N-]=[N+]=CC(=O)C1CCN(C(=O)OCC2c3ccccc3-c3ccccc32)CC1>>O=C(CBr)C1CCN(C(=O)OCC2c3ccccc3-c3ccccc32)CC1,,C1CCOC1,O,,,val
US20140323435A1,CC(C)(C)OC(=O)NCCN.O=S(=O)(Oc1nc(-c2ccncc2)nc2sc3c(c12)CCCCC3)c1ccccc1>>NCCNc1nc(-c2ccncc2)nc2sc3c(c12)CCCCC3,,CC(=O)N(C)C,,CCN(CC)CC,,val
US20120053173A1,CCCC(=O)CC(=O)OC.COC(OC)N(C)C.NN>>CCCc1n[nH]cc1C(=O)OC,,CCO,,O,,val
US20130158056A1,Brc1ccc2cccnc2n1.Cc1nc(C)c(CNc2nc(OCCO)nc(Cl)c2C)s1>>Cc1nc(C)c(CNc2nc(OCCOc3ccc4cccnc4n3)nc(Cl)c2C)s1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20140275030A1,CNC(=O)C1(c2ccccn2)COc2cccc([N+](=O)[O-])c2N1>>CNC(=O)C1(c2ccccn2)COc2cccc(N)c2N1,[Pd],CO,,[H][H],,val
US20050009843A1,CC(C)(C)OC(=O)N1CCC[C@@H](OC(=O)NCCCCl)C1.CNC>>CN(C)CCCNC(=O)O[C@@H]1CCCN(C(=O)OC(C)(C)C)C1,,CCO,,,,val
US04621084,CC(Br)C(=O)c1ccc2c(c1)NC(=O)C(C)O2.Cc1ccnc(N)c1>>Cc1ccn2c(C)c(-c3ccc4c(c3)NC(=O)C(C)O4)nc2c1,,CC#N,,,,val
US20100179139A1,CNC1CCS(=O)(=O)CC1.O=S(=O)(Cl)c1ccc(Br)cn1>>CN(C1CCS(=O)(=O)CC1)S(=O)(=O)c1ccc(Br)cn1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04822729,CCCCCCCCCCCCC(Oc1cccc(N)c1)C(=O)OCC.O=C(Cl)C(F)(F)C(F)Cl>>CCCCCCCCCCCCC(Oc1cccc(NC(=O)C(F)(F)C(F)Cl)c1)C(=O)OCC,,ClCCl,c1ccncc1,,,val
US20040132727A1,COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.NNC1CCCCC1.S=C(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=S)NNC4CCCCC4)c(C)c3C)c2cc1OC,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20160251339A1,COCc1c[nH]c2cc(Cl)ccc12.COc1ccc(S(=O)(=O)Cl)cc1N1CCN(C(=O)C(F)(F)F)CC1>>COCc1cn(S(=O)(=O)c2ccc(OC)c(N3CCN(C(=O)C(F)(F)F)CC3)c2)c2cc(Cl)ccc12,,C1CCOC1,,[H-].[Na+],,val
US20050131014A1,COC(=O)c1cccc(CBr)c1.Oc1cccc(Cc2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1>>COC(=O)c1cccc(COc2cccc(Cc3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)c1,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20050239777A1,COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1O.ClCCl.O=C1COCCN1CCO>>COC1(Nc2ccc(Cl)cc2F)NC=Nc2cc(OCCN3CCOCC3=O)ccc21.Cl,,C1CCOC1,ClCCl,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06040309,CCOC(=O)c1sc2cc(OCc3ccccc3)ccc2c1Sc1ccccc1.OO>>CCOC(=O)c1sc2cc(OCc3ccccc3)ccc2c1S(=O)c1ccccc1,,C1CCOC1,CC(=O)O,O,,val
US20050192302A1,CCOC(C)=O.COC(=O)c1c[nH]cn1.FC(F)(F)c1ccnc(Cl)c1>>CCOC(=O)c1cn(-c2cc(C(F)(F)F)ccn2)cn1,,CN(C)C=O,,[H-].[Na+],,val
US20090029994A1,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCN(CC1CCCCC1)c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ncc(OCCCO)cn1>>CCN(CC1CCCCC1)c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ncc(OCCC(=O)O)cn1,,ClCCl,,CCOC(C)=O,,val
US20060063762A1,CC1=C(CC=O)C(N2CCOCC2)[C@](C)(S(=O)(=O)[O-])C=C1.O=C([O-])[O-].OCCc1c[nH]c2c(O)cccc12>>C[C@H](Oc1cccc2c(CCO)c[nH]c12)C(=O)N1CCOCC1,,CN(C)C=O,,O,,val
US20060079535A1,ClCCCCI.O=c1ccc2c(O)c3ccoc3cc2o1>>O=c1ccc2c(OCCCCCl)c3ccoc3cc2o1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05763463,N#Cc1ccncc1Cl.OO>>N#Cc1cc[n+]([O-])cc1Cl,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040092546A1,NN.O=C(c1cc(S(=O)(=O)NCCN2CCOCC2)c[nH]1)c1cccnc1Cl>>O=S(=O)(NCCN1CCOCC1)c1c[nH]c(-c2n[nH]c3ncccc23)c1,,CCO,,O,,val
US20150025073A1,CI.Cc1cc(C(=O)N2CCC3(CC2)CN(Cc2ccccc2)CC(C(=O)O)O3)ccc1OC(C)C>>COC(=O)C1CN(Cc2ccccc2)CC2(CCN(C(=O)c3ccc(OC(C)C)c(C)c3)CC2)O1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20160024065A1,CI.N#Cc1cccc(Cl)c1N>>CNc1c(Cl)cccc1C#N,,CN(C)C=O,,[H-].[Na+],,val
US20090247551A1,CI.CN(Cc1cnc(Cl)c(Cl)c1)C1=CC(=O)OC1>>CC1OC(=O)C=C1N(C)Cc1cnc(Cl)c(Cl)c1,,C1CCOC1,CCCCC,[Li]C(C)(C)C,,val
US20100016373A1,CC(C)(C)CC(=O)c1ccc(OCc2ccc(CNC(=O)c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)cc2)c(C(F)(F)F)c1O>>CC(C)(C)CC(=O)c1ccc(OCc2ccc(CNC(=O)c3c[nH]cn3)cc2)c(C(F)(F)F)c1O,,CCO,,Cl,,val
US05116846,CC(C)(C)[Si](C)(C)Oc1ccc(C(=O)CC2CCN(Cc3ccccc3)CC2)cc1>>O=C(CC1CCN(Cc2ccccc2)CC1)c1ccc(O)cc1,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US06069141,CC(=O)NCC1CC(c2ccc(N3CCSCC3)c(F)c2)=NO1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(=S)NCC1CC(c2ccc(N3CCSCC3)c(F)c2)=NO1,,C1COCCO1,,ClCCl,,val
US20130143859A1,Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(=O)OC(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1.O=C(O)C(F)(F)F>>Cc1cc(C2CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1.O=C(O)C(F)(F)F,,ClCCl,,,,val
US20100240671A1,COC(=O)C(NC(=O)OC(C)(C)C)P(=O)(OC)OC.O=Cc1cccc(O)c1>>COC(=O)C(=Cc1cccc(O)c1)NC(=O)OC(C)(C)C,,CCOC(C)=O,ClCCl,C1CCC2=NCCCN2CC1,,val
US20150322056A1,Brc1cc2n(n1)CCC2.Cl>>Brc1cc2n(n1)CCC2.Cl,,COC(C)(C)C,,,,val
US20080171737A1,NOc1ccccc1.O=S(=O)(Cl)CCl>>O=S(=O)(CCl)Nc1ccccc1O,,C1CCOC1,,Cl,c1ccncc1,val
US20080318940A1,C=C1CCN(C(C)=O)c2ccc3c(=O)n(-c4ccc(Cl)cc4)c(C(C)C)nc3c21>>C=C1CCNc2ccc3c(=O)n(-c4ccc(Cl)cc4)c(C(C)C)nc3c21,,CO,,Cl,[K+].[OH-],val
US20150094328A1,Cc1cccc(-c2ccc(C=O)c(F)c2)n1>>Cc1cccc(-c2ccc(CO)c(F)c2)n1,,CO,,[BH4-].[Na+],,val
US20090137557A1,Cc1nc(-c2ccccc2)n(CCc2ccccc2)c(=O)c1Br.OB(O)c1ccccc1>>Cc1nc(-c2ccccc2)n(CCc2ccccc2)c(=O)c1-c1ccccc1,,C1COCCO1,CCO,O=C([O-])[O-].[Na+].[Na+],,val
US20060128695A1,COc1cc2c(cc1OC)C(c1ccccc1)=NCC(=O)N2.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COc1cc2c(cc1OC)C(c1ccccc1)=NCC(=S)N2,,Cc1ccccc1,,,,val
US20150307497A1,BrCC1CCCO1.COC(=O)c1c(O)cccc1C(OC)OC>>COC(=O)c1c(OCC2CCCO2)cccc1C(OC)OC,,CN(C)C=O,O,[H-].[Na+],,val
US20090324581A1,C=C(C)c1ccc(CO)cc1C(F)(F)F.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1>>C=C(C)c1ccc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cc1C(F)(F)F,CN(C)c1ccncc1,ClCCl,,,,val
US07053099B1,N#Cc1c(F)cccc1F.Nc1c(F)cccc1F>>N#Cc1c(F)cccc1Nc1c(F)cccc1F,,CS(C)=O,,,,val
US20040167123A1,CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(N)ccc3N2)c(O)c2cccnc21.O=S(=O)(Cl)c1c(Cl)cccc1Cl>>CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(NS(=O)(=O)c4c(Cl)cccc4Cl)ccc3N2)c(O)c2cccnc21,,c1ccncc1,,,,val
US04297365,CCCCN=C=S.CCN(CC)C(C)=N.O=C(CBr)c1ccc(Cl)c([N+](=O)[O-])c1>>CCCCNc1nc(C)c(C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)s1,,CC(C)O,,,,val
US20120178751A1,CC(C)OB(OC(C)C)OC(C)C.FC(F)(F)c1ccncc1Br>>OB(O)c1cnccc1C(F)(F)F,,C1CCOC1,,[Li]CCCC,,val
US20080280868A1,O=C(O)c1cnc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F>>OCc1cnc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F,,COCCOC,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20130137691A1,N#CCc1ccccc1.NO>>N=C(Cc1ccccc1)NO,,CCO,,CCN(CC)CC,Cl,val
US20070117800A1,CCOC(=O)c1ccc(-c2ccnc(Nc3cccnc3)n2)s1>>O=C(O)c1ccc(-c2ccnc(Nc3cccnc3)n2)s1,,CO,O,Cl,[Li+].[OH-],val
US04076838,CC(CCc1ccc(CC(=O)O)cc1)CC(=O)O>>CC1CCc2ccc(CC(=O)O)cc2C(=O)C1,,O,,,,val
US20130178486A1,C#C[Si](C)(C)C.Nc1cc(F)cnc1Br>>C[Si](C)(C)C#Cc1ncc(F)cc1N,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1CCOC1,,,,val
US20100260710A1,COc1ccc(C(C)=O)c(N)c1C.O=C(O)c1nc(C(F)(F)F)cs1>>COc1ccc(C(C)=O)c(NC(=O)C2=NC(C(F)(F)F)CS2)c1C,,C1COCCO1,ClCCl,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US06518257B1,CC(C)C(O)(c1cccc(Br)c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.CCB(CC)c1cccnc1>>CC(C)C(O)(c1cccc(-c2cccnc2)c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US05543415,CCCn1c(=O)c2c(nc(/C=C/c3ccc(OC)c(OC)c3)n2C)n(CCC)c1=O>>CCCn1c(=O)c2c(nc(/C=C\c3ccc(OC)c(OC)c3)n2C)n(CCC)c1=O,,CO,,,,val
US20060025474A1,CCC(CC)(c1ccc(O)c(C)c1)c1ccc(OC[C@@H]2COC(C)(C)O2)c(C)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCC(CC)(c1ccc(OC[C@@H]2COC(C)(C)O2)c(C)c1)c1ccc(OS(=O)(=O)C(F)(F)F)c(C)c1,,ClCCl,,c1ccncc1,O=C([O-])O.[Na+],val
US06316632B1,CC(=O)Nc1cccnc1-c1ccccc1.Cl>>Cl.Nc1cccnc1-c1ccccc1,,C1CCOC1,,Cl,,val
US20020013492A1,C=C(C)C(=O)OCCNC.O=C(Cl)Cl>>C=C(C)C(=O)OCCN(C)C(=O)Cl,,ClCCl,,Cl,,val
US05929085,CCC1Cc2ccccc2C2OC(=O)C(=O)N12>>CCC1Cc2ccccc2C=N1,,CO,,O=S(=O)(O)O,,val
US20120046267A1,Br.CC(C)(C)OC(=O)Nc1c(F)cccc1I>>Fc1cccc(I)c1Br,[Cu]Br,CCO,O,O=N[O-].[Na+],,val
US20070010402A1,CN.Cc1cc2c(-c3ccc(C(F)(F)F)cc3)nc(Cl)nc2s1>>CNc1nc(-c2ccc(C(F)(F)F)cc2)c2cc(C)sc2n1,,C1CCOC1,,CO,,val
US20090247538A1,Clc1ncnc2[nH]ccc12.NC1(Cc2ccc(Cl)cc2)CCNCC1>>NC1(Cc2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1,,CCCCO,,CCN(CC)CC,Cl,val
US20100016396A1,COc1ccc(COc2cc(Oc3c(C(O)C(C)C)c(C)nn3C)c(Cl)cc2Cl)cc1>>Cc1nn(C)c(Oc2cc(O)c(Cl)cc2Cl)c1CC(C)C,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20120258994A1,CCOC(=O)Cc1ccc(Cl)c(Cl)c1.O=C1CCC(=O)N1Br>>CCOC(=O)C(Br)c1ccc(Cl)c(Cl)c1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20080287394A1,BrCc1ccccc1.CCOC(=O)c1cn2c(c1O)C(=O)N(Cc1ccc(F)cc1)CC2>>CCOC(=O)c1cn2c(c1OCc1ccccc1)C(=O)N(Cc1ccc(F)cc1)CC2,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060205718A1,CC(C)(C)OC(=O)N1CCC(N)CC1.CSc1nc2cc([N+](=O)[O-])ccc2o1>>CC(C)(C)OC(=O)N1CCC(Nc2nc3cc([N+](=O)[O-])ccc3o2)CC1,,CC(=O)N(C)C,,,,val
US20120040949A1,CC(C)(C)OC(=O)Nc1cnc(CBr)cn1.NC1CCC1>>CC(C)(C)OC(=O)Nc1cnc(CNC2CCC2)cn1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20110034497A1,CC(C)C(=O)Cl.Nc1cncc(Br)c1>>CC(C)C(=O)Nc1cncc(Br)c1,,ClCCl,,c1ccncc1,,val
US05571813,CCc1cc(Nc2ccc(N)cc2)n2nccc2n1.O=C1OS(=O)(=O)c2ccccc21>>CCc1cc(Nc2ccc(NC(=O)c3ccccc3S(=O)(=O)O)cc2)n2nccc2n1,,ClCCl,,,,val
US20110306621A1,Fc1cncc(F)c1.II>>Fc1cncc(F)c1I,,CCOCC,O,CN(C)CCN(C)C,[Li]CCCC,val
US20130102586A1,COc1ccc(Cn2nc(C)c3cc(-c4cccc(C(=O)[O-])c4)cnc32)cc1.ClC(Cl)Cl>>CCOC(=O)c1cccc(-c2cnc3[nH]nc(C)c3c2)c1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US05137660,CCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCC.CCCCCCCCCCCCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCCCCCCCCCCCC>>CCCCCCCCCCCCCCCCCCCCCC(=O)OC(COC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC,,ClCCl,,,,val
US20140228396A1,Cc1ccc(NC(=N)c2cncc(Br)c2)nc1>>Cc1ccc2nc(-c3cncc(Br)c3)nn2c1,,Cc1ccccc1,,,,val
US05948820,CCCCCCCCCCCc1ccc(CCCC(CCOC(C)=O)(COC(C)=O)NC(C)=O)cc1>>CCCCCCCCCCCc1ccc(CCCC(N)(CO)CCO)cc1,,CO,O,[Li+].[OH-],,val
US20120288492A1,CCOC(=O)c1nc(-c2ccc(NC(=O)Oc3ccccc3)cc2)nc(N2CCOCC2)c1OCC.CN1CCN(N)CC1>>CCOC(=O)c1nc(-c2ccc(NC(=O)NN3CCN(C)CC3)cc2)nc(N2CCOCC2)c1OCC,,C1COCCO1,,CCN(CC)CC,,val
US20060089380A1,CC(C)Oc1c(Cl)cc(Cl)c2ccc(-c3ccccn3)nc12>>Oc1c(Cl)cc(Cl)c2ccc(-c3ccccn3)nc12,,ClCCl,,ClB(Cl)Cl,,val
US20130079324A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N=C(N)n1cccn1>>CC(C)(C)OC(=O)NC(=N)n1cccn1,CN(C)c1ccncc1,C1CCOC1,,CCN(CC)CC,Cl,val
US05747517,COc1c(C(C)(C)C)cc(CBr)cc1C(C)(C)C.O=Cc1ccc(O)cc1>>COc1c(C(C)(C)C)cc(COc2ccc(C=O)cc2)cc1C(C)(C)C,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130123235A1,CCCC[Sn](/C=C\CN1CC[C@@H](OC(C)=O)C1)(CCCC)CCCC.COC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2Br)ccc2c1OCc1occc1-2>>COC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2/C=C\CN2CC[C@@H](OC(C)=O)C2)ccc2c1OCc1occc1-2,,C1COCCO1,CS(C)=O,,,val
US04005212,CSc1ccc(C2CO2)cc1.NCCN>>CSc1ccc(C(O)CNCCN)cc1,,CO,,CCO,,val
US20030166668A1,O=Cc1cc(Br)cs1.OCCO>>Brc1csc(C2OCCO2)c1,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,,,val
US20140378692A1,CCCCCCCCCCCC(=O)OC>>CCCCCCCCCCCC(=O)O,,O,,,,val
US06635655B1,Cc1cccc(C)c1C(=O)O.ClCCl>>COC(=O)c1c(C)cccc1C,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US20150045349A1,CC1(C)OB(c2csc(CC#N)c2)OC1(C)C.Nc1n[nH]c2c(Br)cn(-c3ccccc3Cl)c(=O)c12>>N#CCc1cc(-c2cn(-c3ccccc3Cl)c(=O)c3c(N)n[nH]c23)cs1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,CN(C)C=O,O=C([O-])[O-].[Na+].[Na+],val
US20080261973A1,CS(=O)(=O)Nc1cccc(Nc2nc(Cl)c3nc[nH]c3n2)c1.Oc1ccc(F)cc1>>CS(=O)(=O)Nc1cccc(Nc2nc(Oc3ccc(F)cc3)c3nc[nH]c3n2)c1,,C1CCOC1,,[H-].[Na+],,val
US20080125441A1,C(=C1CCC2(CC1)OCCO2)c1ccc(OCc2ccccc2)cc1>>O=C1CCC(Cc2ccc(O)cc2)CC1,[Pd],CCOCC,CO,,,val
US20080221106A1,CCOc1cc(C=CC(C)=O)ccc1O.COS(=O)(=O)OC>>CCOc1cc(C=CC(C)=O)ccc1OC,,CC(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20060276433A1,O=Cc1ccc(NC(=O)C(F)(F)F)c(I)c1.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>Nc1ccc(-c2cnco2)cc1I,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20130252937A1,COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(OCCC(C)(C)O)cc5C)ccc(F)c43)ccc21>>Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Oc1ccc2c(c1)OC[C@H]2CC(=O)O,,CO,,[Na+].[OH-],,val
US04590198,CCN(CC)CC.CCN(CC)c1ccccc1.O=C(C1=NC=CC(Cl)(C(=O)Nc2ccccc2)C1)c1ccccc1.O=C(Nc1ccccc1)c1ccnc(C(=O)c2ccc(Cl)cc2)c1>>CCOC(Nc1ccccc1)(OCC)C1(Cl)C=CN=C(C(=O)c2ccccc2)C1,,CCN(CC)CC,,,,val
US04956462,COC(=O)c1cc(O)n2nc(CO)nc2n1>>OCc1cc(O)n2nc(CO)nc2n1,,CCO,,[BH4-].[Na+],,val
US20100105653A1,CC(C)(C)[SiH2]OC(C)(C)c1ccc(Nc2ncc3cc(C#N)n(C4CCCC4)c3n2)nc1>>N#Cc1cc2cnc(Nc3ccc(CO)cn3)nc2n1C1CCCC1,,C1CCOC1,CCOC(C)=O,c1ccncc1,O=C([O-])O.[Na+],val
US20090156607A1,CCCC1CC(=O)N(Cc2c[nH]cn2)C1.O=C1CCC(=O)N1Cl>>CCCC1CC(=O)N(Cc2[nH]cnc2Cl)C1,,C1CCOC1,CC#N,,,val
US20150299189A1,Cn1ccc2cc([N+](=O)[O-])cc(-c3ccc(-c4ccccc4)cc3)c21>>Cn1ccc2cc(N)cc(-c3ccc(-c4ccccc4)cc3)c21,[Fe],O,,CCO,[Cl-].[NH4+],val
US20130042918A1,O=C1CCC(=O)N1I.O=Cc1cc2sccc2s1>>O=Cc1cc2sc(I)cc2s1,,ClC(Cl)Cl,,CC(=O)O,,val
US06235851B1,O=O.O=[N+]([O-])C12CC3CC(CC(C3)C1)C2>>O=[N+]([O-])C12CC3CC(CC(O)(C3)C1)C2,,CC(=O)O,,,,val
US04122199,NCCN1CCCC1.O=C(Cl)C(Cl)(c1ccccc1)c1ccccc1>>Cl.O=C(NCCN1CCCC1)C(Cl)(c1ccccc1)c1ccccc1,,CC(C)=O,,,,val
US20140206663A1,O=[N+]([O-])c1cc(Br)c(C(F)(F)F)cc1O>>Nc1cc(Br)c(C(F)(F)F)cc1O,[Zn],CO,,[Cl-].[NH4+],,val
US04806143,COC(=O)Cc1c[nH]c2c(Cl)cc(Cl)c(Cl)c12>>O=C(O)Cc1c[nH]c2c(Cl)cc(Cl)c(Cl)c12,,CO,O,[K+].[OH-],,val
US20110166132A1,BrCC1CC1.COC(=O)C(C(=O)OC)c1ccc([N+](=O)[O-])cn1>>COC(=O)C(CC1CC1)(C(=O)OC)c1ccc([N+](=O)[O-])cn1,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20100190788A1,O=C(Cl)C(=O)Cl.O=C(NCC(=O)c1ccc(C(=O)O)cc1)OCc1ccccc1>>O=C(NCC(=O)c1ccc(C(=O)Cl)cc1)OCc1ccccc1,CN(C)C=O,ClCCl,,,,val
US20120107248A1,CC(C)(C)OC(=O)NCCCCCOS(C)(=O)=O.[I-]>>CC(C)(C)OC(=O)NCCCCCI,,CN(C)C=O,,O,,val
US20090281076A1,CS(=O)(=O)c1ccc(-c2ccc(OC3CN(C(=O)C(F)(F)F)C3)cc2)cn1>>CS(=O)(=O)c1ccc(-c2ccc(OC3CNC3)cc2)cn1,,CO,O,O=C([O-])[O-].[K+].[K+],,val
US20070049632A1,BrCc1ccccc1.CC1(C)[C@@H]2CC[C@@]1(C)c1[nH]n(-c3ccccc3)c(=O)c12>>CC1(C)[C@@H]2CC[C@@]1(C)c1c2c(=O)n(-c2ccccc2)n1Cc1ccccc1,,CC(C)=O,CO,O=C([O-])[O-].[K+].[K+],,val
US20130331372A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCc1ccc(-c2ccc(C(=O)OC)cc2C)cc1I>>CCc1ccc(-c2ccc(C(=O)OC)cc2C)cc1B1OC(C)(C)C(C)(C)O1,,CS(C)=O,,C1COCCO1,CC(=O)[O-].[K+],val
US20070281933A1,CCS(=O)(=O)N1CCC(c2n[nH]c3c(C(N)=O)cc(-c4cccc(CO)c4)cc23)CC1>>CCS(=O)(=O)N1CCC(c2n[nH]c3c(C(N)=O)cc(-c4cccc(C=O)c4)cc23)CC1,O=[Mn]=O,C1CCOC1,,,,val
US05519040,CN(C)CCCC(O)c1ncc(S(N)(=O)=O)s1>>CN(C)CCCC(=O)c1ncc(S(N)(=O)=O)s1,O=[Mn]=O,C1CCOC1,,,,val
US20130172384A1,O=C(C1CC1)N1CC[C@@H](Cn2c(-c3ccc(Br)cc3)n[nH]c2=O)C1.OB(O)c1ccc(F)cc1>>O=C(C1CC1)N1CC[C@@H](Cn2c(-c3ccc(-c4ccc(F)cc4)cc3)n[nH]c2=O)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20070004725A1,CNC.COC(=O)CCc1ccccc1Oc1ccc(CC(NC(=O)OC(C)(C)C)C(=O)O)cc1>>COC(=O)CCc1ccccc1Oc1ccc(CC(NC(=O)OC(C)(C)C)C(=O)N(C)C)cc1,,ClCCl,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20060252768A1,CCOC(=O)C(=O)c1ccc(F)cc1OC.NCCN>>COc1cc(F)ccc1C1=NCCNC1=O,,CCO,,,,val
US20110082133A1,COC(=O)c1ccc(CCn2c(CBr)c(Br)ccc2=O)cc1.Cc1ccc2c(c1)NCC2>>COC(=O)c1ccc(CCn2c(CN3CCc4ccc(C)cc43)c(Br)ccc2=O)cc1,,CN1CCCC1=O,,CCOC(C)=O,O,val
US20110319392A1,CN(C)C(N)=S.O=C(Cc1ccnc(Cl)n1)c1ccc(F)c(NS(=O)(=O)c2c(F)cccc2F)c1>>CN(C)c1nc(-c2ccc(F)c(NS(=O)(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Cl)n2)s1,,ClCCl,,O=C1CCC(=O)N1Br,,val
US20130085141A1,CC(C)(C)OC(=O)N1CCN2C[C@@H](N)C[C@H]2C1.FC(F)(F)c1cccc(Cl)n1>>CC(C)(C)OC(=O)N1CCN2C[C@@H](Nc3cccc(C(F)(F)F)n3)C[C@H]2C1,,CS(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20160000760A1,CC(C)(C)N1CC(OC(=O)Nc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)C1.Nc1nc(Nc2cc(Cl)c(Br)c(C(F)(F)F)c2)n[nH]1>>CC(C)(C)N1CC(OC(=O)Nc2ccc(-c3c(Cl)cc(Nc4n[nH]c(N)n4)cc3C(F)(F)F)cc2)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
US20150376136A1,Cc1cccc(C)n1.O=C(Br)CBr>>O=C(CBr)c1ccc[nH]1,,ClC(Cl)Cl,,,,val
US20150191483A1,CC(C)(C)OC(=O)N1CCC(CO)(C(=O)N2CC[C@](c3ccc(C(OCc4c(F)cccc4F)(C(F)(F)F)C(F)(F)F)cc3)(S(=O)(=O)c3ccc(F)cc3)C2)CC1.Cl>>Cl.O=C(N1CC[C@](c2ccc(C(OCc3c(F)cccc3F)(C(F)(F)F)C(F)(F)F)cc2)(S(=O)(=O)c2ccc(F)cc2)C1)C1(CO)CCNCC1,,C1COCCO1,ClCCl,,,val
US05859014,O=CN1CCNCC1.O=[N+]([O-])c1ccccc1Cl>>O=CN1CCN(c2ccccc2[N+](=O)[O-])CC1,,O,,CN(C)C=O,,val
US20160016948A1,CC(C)(CO[Si](C)(C)C(C)(C)C)Nc1cc(Br)ncc1[N+](=O)[O-]>>CC(C)(CO[Si](C)(C)C(C)(C)C)Nc1cc(Br)ncc1N,O=[Pt]=O,,,,,val
US04774373,C=C.ClCCCl.ClCl.Cl[Fe](Cl)Cl>>CC(Cl)Cl.ClCC(Cl)Cl,Cl[Fe](Cl)Cl,,,,,val
US20100173880A1,Nc1ccccc1.O=C(O)C(Br)c1ccccc1>>O=C(O)C(Nc1ccccc1)c1ccccc1,,ClCCl,,,,val
US20100234389A1,CC(C)(C)OC(=O)N1CCN(c2cc(Cl)ncn2)CC1.OB(O)c1ccccc1F>>CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccccc3F)ncn2)CC1,,O,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20100331312A1,CC(C)OB(OC(C)C)OC(C)C.C[C@@H]1CCCN1CCc1ccc(Br)cc1>>C[C@@H]1CCCN1CCc1ccc(B(O)O)cc1,,C1CCOC1,,[Li]CCCC,,val
US20140107094A1,COc1nc2ccc(Br)cc2c(Cl)c1Cc1ccc(-n2cccn2)cc1.Cn1cncc1C(=O)c1ccc(Cl)cc1>>COc1nc2ccc(C(O)(c3ccc(Cl)cc3)c3cncn3C)cc2c(Cl)c1Cc1ccc(-n2cccn2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20100234395A1,CNO.COc1ccc(-c2nc(C3(COC(C)=O)CCNCC3)oc2-c2ccc(OC)cc2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1ccc(-c2nc(C3(COC(C)=O)CCN(C(=O)N(C)O)CC3)oc2-c2ccc(OC)cc2)cc1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20090247526A1,NC(=S)Nc1cc(OCc2ccccc2)c(Br)cn1.O=C(CBr)CCc1ccccc1>>Brc1cnc(Nc2nc(CCc3ccccc3)cs2)cc1OCc1ccccc1,,CCO,,CCN(CC)CC,,val
US20120108585A1,COC(=O)c1cccc(O)c1N.O=C(O)c1ccccc1C(F)(F)F>>COC(=O)c1cccc2oc(-c3ccccc3C(F)(F)F)nc12,,O,,,,val
US20150072998A1,CCCCSCSc1nc(-c2ccccc2)nc(-c2ccccc2)c1C#N.OO>>CCCCSCS(=O)c1nc(-c2ccccc2)nc(-c2ccccc2)c1C#N,,CCOC(C)=O,ClC(Cl)Cl,CC(=O)O,,val
US20100056530A1,COC(=O)c1cnc(Cl)c(N=C=S)c1.Nc1ncc(Br)cc1OCc1ccccc1>>COC(=O)c1cnc2sc(Nc3ncc(Br)cc3OCc3ccccc3)nc2c1,,CN(C)C=O,,,,val
US20010025047A1,CCOC(=O)c1cnc2c(c(C)nn2C)c1Cl.COc1ccc(S(=O)(=O)NCc2cccnc2)cc1>>CCOC(=O)c1cnc2c(c(C)nn2C)c1N(Cc1cccnc1)S(=O)(=O)c1ccc(OC)cc1,,CN1CCCC1=O,,O,[H-].[Na+],val
US20120046268A1,O=C(NC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCC3(CC2)OCCO3)C1)C1CCCC1>>O=C1CCN(C(=O)N2CC(NC(=O)C3CCCC3)CC(c3ccc(C(F)(F)F)cc3)C2)CC1,,CC(C)=O,O,Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1,,val
US20100093730A1,O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O.[H]/N=C(\NO)c1ccc(C(F)(F)F)cc1>>O=C1N(Cc2nc(-c3ccc(C(F)(F)F)cc3)no2)CCC1(c1ccccc1)c1ccccc1,,CC(Cl)Cl,,CCN=C=NCCCN(C)C,Cl,val
US20100093706A1,CC(=O)N[C@H](CC(C)C)C(=O)O.CCO>>C.COC(=O)[C@@H]1CC[C@H](C)NC1,,CCO,,CCOC(C)=O,,val
US20110003784A1,CC1=C(/C=C/C(=O)O)C(C)(C)CCC1.O=C(Cl)C(=O)Cl>>CC1=C(/C=C/C(=O)Cl)C(C)(C)CCC1,CN(C)C=O,ClCCl,,,,val
US20030078260A1,Cc1ccc(C)n1-c1ccc([C@@H](O)CNC(=O)[C@H]2CCc3cc(I)ccc3O2)cn1>>Cc1ccc(C)n1-c1ccc([C@@H](O)CNC[C@H]2CCc3cc(I)ccc3O2)cn1,,C1CCOC1,,B,CSC,val
US20120040985A1,CCOC(=O)NS(=O)(=O)c1cc(F)c(CSc2ncc(C(C)(C)c3ccc(Cl)c(OC)c3)n2-c2ccc(F)cc2)c(F)c1.NN1CCOCC1>>COc1cc(C(C)(C)c2cnc(SCc3c(F)cc(S(=O)(=O)NC(=O)NN4CCOCC4)cc3F)n2-c2ccc(F)cc2)ccc1Cl,,CCOC(C)=O,Cc1ccccc1,,,val
US04048330,Br[Mg]c1ccc2ccccc2c1.O=C1CCC1>>OC1(c2ccc3ccccc3c2)CCC1,,CCOCC,,Cl,,val
US20130150368A1,Clc1cc(Br)ccn1.NC1(c2ccccc2)CCC1>>Brc1ccnc(NC2(c3ccccc3)CCC2)c1,,CCOC(C)=O,O,CN1CCCC1=O,,val
US20160115158A1,N#C[Cu].O=S(=O)(Nc1cncc(Br)c1O)c1cc(Cl)cc(Cl)c1>>N#Cc1cncc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1O,,CCOC(C)=O,CN1CCCC1=O,,,val
US04734501,CN1CC(C(=O)O)CC2c3cccc4[nH]cc(c34)CC21.Cc1ccc(S(=O)(=O)OC2CCCC2)cc1>>CN1CC(C(=O)O)C[C@@H]2c3cccc4c3c(cn4C3CCCC3)C[C@H]21,,CS(C)=O,,[K+].[OH-],,val
US20120142752A1,CC(C)(C)OC(=O)N1C[C@@H](N)[C@H](CCCO)C1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CC(C)(C)OC(=O)N1C[C@@H](CCCO)[C@H](NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)C1,,C1CCOC1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20090018103A1,CNC(=O)NCCC[C@@](O)(c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1>>CNC(=O)NCCC[C@@](O)(c1cccc(Cl)c1)[C@@H]1CCCNC1,,CC#N,,Cl,,val
US20070270588A1,CCC(N)CC.CCOC(=O)Cc1c(C)nc(N(CC)c2c(C)cc(C)cc2C)nc1OS(=O)(=O)C(F)(F)F>>CCC(CC)N1C(=O)Cc2c(C)nc(N(CC)c3c(C)cc(C)cc3C)nc21,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US07582626B2,CC(C)CCN1C(=O)C(C2=NS(=O)(=O)c3cc(NS(C)(=O)=O)ccc3N2)=C(O)C2CCCCCC21.CI>>CC(C)CCN1C(=O)C(C2=NS(=O)(=O)c3cc(N(C)S(C)(=O)=O)ccc3N2)=C(O)C2CCCCCC21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20150126490A1,COC(=O)c1ccc(-c2nc(C3=CCC4(CC3)OCCO4)cnc2N)cc1F>>COC(=O)c1ccc(-c2nc(C3CCC4(CC3)OCCO4)cnc2N)cc1F,[Pd],CO,,[H][H],,val
US20140045828A1,NC1=NC2(COC1C1CCCCC1)c1cc(Br)ccc1Oc1cnc(Cl)cc12.OB(O)c1cccnc1F>>NC1=NC2(COC1C1CCCCC1)c1cc(-c3cccnc3F)ccc1Oc1cnc(Cl)cc12,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[Na+].[Na+],val
US20060148858A1,COC(=O)Cc1cccc(F)c1O.OCCCc1cn(-c2ccc(C(F)(F)F)cn2)nc1C1CCCCC1>>O=C(O)Cc1cccc(F)c1OCCCc1cn(-c2ccc(C(F)(F)F)cn2)nc1C1CCCCC1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20120171245A1,CS(=O)(=O)Cl.Fc1cnc(-c2c[nH]c3ncc(Cl)cc23)nc1NC[C@@H]1CCCNC1>>CS(=O)(=O)N1CCC[C@@H](CNc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)C1,,ClCCl,,c1ccncc1,,val
US20090163512A1,COC(=O)C(C)(C)COc1ccc(Cl)cc1C=O.O=C1Cc2ccc(Cl)cc2N1>>COC(=O)C(C)(C)COc1ccc(Cl)cc1/C=C1\C(=O)Nc2cc(Cl)ccc21,,CO,,C1CCNC1,,val
US20080045568A1,CC(O)CN.Cc1ccccc1.O=C1OC(=O)c2ccccc21>>CC(O)CNC(=O)OCc1ccccc1,,O,,CCN(CC)CC,,val
US04737513,C#CCBr.O=Cc1cc[nH]c1>>C=C=Cn1ccc(C=O)c1,,C1CCOC1,,O,[H-].[Na+],val
US20090149475A1,CC(C)c1cc(CN)on1.O=C(N=C=S)c1ccccc1>>CC(C)c1cc(CNC(N)=S)on1,,CO,N,,,val
US05935952,CCN(CC)S(F)(F)F.CCOC(=O)c1cn(C2CC2)c2c(CO)c(Br)c(F)cc2c1=O>>CCOC(=O)c1cn(C2CC2)c2c(CF)c(Br)c(F)cc2c1=O,,ClCCl,,O=C([O-])O.[Na+],,val
US20160102059A1,CN(C)CCN.COc1cc(NC(=O)OC(C)(C)C)cc(OC)c1C(=O)O>>COc1cc(NC(=O)OC(C)(C)C)cc(OC)c1C(=O)NCCN(C)C,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20050075392A1,Cc1ccc(CO)cn1.O=S(Br)Br>>Br.Cc1ccc(CBr)cn1,,ClCCl,,,,val
US20090042892A1,CC(C)c1ccc(Cl)c(Br)c1.COB(OC)OC>>CC(C)c1ccc(Cl)c(B(O)O)c1,,C1CCOC1,,[Li]CCCC,,val
US20120142713A1,O=P(O)(O)O.c1ccc(-c2ncc3cc(-n4ccnc4)ccc3n2)cc1>>O=P(O)(O)O.c1ccc(-c2ncc3cc(-n4ccnc4)ccc3n2)cc1,,CCO,,,,val
US20040180934A1,C=C(C)c1cc(S(C)(=O)=O)cc2c1cc1n2CCC1CC(=O)OC>>COC(=O)CC1CCn2c1cc1c(C(C)C)cc(S(C)(=O)=O)cc12,[Pd],CCO,,,,val
US20140213586A1,CCc1cccc(N)c1.O=C(c1c[nH]c2ccccc12)C(Cl)c1ccccc1>>CCc1cccc(NC(C(=O)c2c[nH]c3ccccc23)c2ccccc2)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20040023964A1,CC1(C)COB(c2ccc(F)c(-n3ccnc3)c2)OC1.FC(F)(F)c1cnn2c(Br)cnc2n1>>Fc1ccc(-c2cnc3nc(C(F)(F)F)cnn23)cc1-n1ccnc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US06107342,CCOC(=O)[C@H]1[C@@H]2CC(=O)[C@@](N=[N+]=[N-])(C(=O)OCc3ccccc3)[C@H]12>>CCOC(=O)[C@H]1[C@@H]2C[C@H](O)[C@@](N=[N+]=[N-])(C(=O)OCc3ccccc3)[C@H]12,,C1CCOC1,CCO,Cl,[BH4-].[Na+],val
US05278314,CC(C)(C)c1cc(CCC(=O)O)cc(-n2nc3ccc(Sc4ccccc4)cc3n2)c1O.CCOC(C)=O.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1C>>CCCCCCCCOC(=O)CCc1cc(-n2nc3ccc(Sc4ccccc4)cc3n2)c(O)c(C(C)(C)C)c1,,CCOC(C)=O,,,,val
US06329380B1,CN(c1nccc(-n2cnc3ccccc32)n1)C1CCNC1.O=C=Nc1cccc2ccccc12>>CN(c1nccc(-n2cnc3ccccc32)n1)C1CCN(C(=O)Nc2cccc3ccccc23)C1,,ClCCl,,,,val
US20130035326A1,CC(C)(C)c1cc(NC(=O)Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)no1.CNc1ccc(Br)cn1>>CNc1ccc(-c2ccc(CC(=O)Nc3cc(C(C)(C)C)on3)cc2)cn1,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20090298815A1,CC(C)c1nc(-c2ccc(F)c(NS(=O)(=O)c3cc(F)ccc3F)c2)c(-c2ccnc(Cl)n2)s1.NC1CCOCC1>>CC(C)c1nc(-c2ccc(F)c(NS(=O)(=O)c3cc(F)ccc3F)c2)c(-c2ccnc(NC3CCOCC3)n2)s1,,C1CCOC1,,,,val
US20140179733A1,C=CCBr.C=Cc1c(C(F)(F)F)nc(C)n1CC(=O)OCC>>C=CCC(C(=O)OCC)n1c(C)nc(C(F)(F)F)c1C=C,,C1CCOC1,,[Cl-].[NH4+],CC(C)[N-]C(C)C.[Li+],val
US20090221555A1,CNC(=O)[C@@H]1CCC[C@@H]1Nc1nc(Cl)ncc1Cl.COc1cc2c(cc1N)CCN(CC(=O)N(C)C)CC2>>CNC(=O)[C@@H]1CCC[C@@H]1Nc1nc(Nc2cc3c(cc2OC)CCN(CC(=O)N(C)C)CC3)ncc1Cl,,CC(C)O,,CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2,,val
US20120157434A1,CC(=O)NC[C@@H]1OC(=O)N2c3ccc([N+](=O)[O-])cc3C[C@@H]12>>CC(=O)NC[C@@H]1OC(=O)N2c3ccc(N)cc3C[C@@H]12,[Pd],CCO,,,,val
US20070093521A1,Cc1nccc([N+](=O)[O-])c1O>>Cc1nccc(N)c1O,[Pd],CO,,,,val
US20020016345A1,Cc1nc(C(F)(F)F)ccc1C(=O)C1=C(Cl)C2CCC(C2)C1=O.Sc1ccc(Cl)cc1>>Cc1nc(C(F)(F)F)ccc1C(=O)C1=C(Sc2ccc(Cl)cc2)C2CCC(C2)C1=O,,ClCCl,,CCN(CC)CC,CN(C)c1ccccn1,val
US20160272617A1,Cc1cc(C(=O)NCC(=O)N2CCC(N(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nnc(C(F)(F)C(F)(F)C(=O)O)[nH]3)cc2)cc1.Cl>>Cc1cc(C(=O)NCC(=O)N2CCC(N(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc(-c3nnc(C(F)(F)C(F)(F)C(=O)O)[nH]3)cc2)cc1.Cl,,C1COCCO1,,CC#N,,val
US20100048564A1,CC(C)(C)OC(=O)NCc1cc(Cl)ccc1[N+](=O)[O-].Cc1ccc(O)cc1F>>Cc1ccc(Oc2ccc([N+](=O)[O-])c(CNC(=O)OC(C)(C)C)c2)cc1F,,CN(C)C=O,,[H-].[Na+],,val
US20130252944A1,COc1ccc(Cn2cc3c(n2)C(O)(C(F)(F)F)CCc2sc(NC(=O)OC(C)(C)C)nc2-3)cc1.O=S(Cl)Cl>>COc1ccc(Cn2cc3c(n2)C(Cl)(C(F)(F)F)CCc2sc(NC(=O)OC(C)(C)C)nc2-3)cc1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US05378689,CN.C[C@@H]1C[C@@H]([C@H](CC2CCCCC2)NC(=O)[C@H](Cc2cscn2)NC(=O)[C@@H](CC(=O)N2CCOCC2)Cc2ccccc2)OC1=O>>CNC(=O)[C@H](C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cscn1)NC(=O)[C@@H](CC(=O)N1CCOCC1)Cc1ccccc1,,CO,,,,val
US20150239901A1,II.c1ccc(Sc2csc3cc4ccccc4cc23)cc1>>Ic1sc2cc3ccccc3cc2c1Sc1ccccc1,,C1CCOC1,,[Li]CCCC,,val
US20100216794A1,COCCBr.Oc1ccc(Br)nc1>>COCCOc1ccc(Br)nc1,,CN(C)C=O,,O,[H-].[Na+],val
US04920128,CCOC(=O)Cn1nc(N)c2cc3cc(OC)ccc3nc21.CNC>>COc1ccc2nc3c(cc2c1)c(N)nn3CC(=O)N(C)C,,CO,,,,val
US20160009721A1,Cc1ccc(-c2c(-c3ccc(C#N)cc3)cc(OC[C@@H]3CCN(C(=O)OC(C)(C)C)C3)c3nncn23)cc1>>Cc1ccc(-c2c(-c3ccc(C#N)cc3)cc(OC[C@@H]3CCNC3)c3nncn23)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05703096,O=C1c2ccccc2C(=O)N1OCCOC1CCCCO1>>O=C1c2ccccc2C(=O)N1OCCO,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20120245161A1,COCCn1cc(C(=O)O)c2c(OC(F)(F)F)ccc(Cl)c21>>COCCn1cc(C(=O)O)c2c(OC(F)(F)F)cccc21,[Pd],CO,,,,val
US20090264445A1,CCOC(=O)C=C(C)Cl.CSc1ccccc1O>>CCOC(=O)/C=C(\C)Oc1ccccc1SC,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20160046617A1,COc1ccc(Cl)cc1C(C#N)C=O.NN>>COc1ccc(Cl)cc1-c1cn[nH]c1N,,CCO,,CC(=O)O,O,val
US20020013328A1,COc1ccc(Cc2nc3n(-c4c(Cl)cc(Cl)cc4Cl)[nH]c(C(F)(F)F)c-3c(=O)n2)cc1OC>>O=c1nc(Cc2cccc(O)c2)nc2n(-c3c(Cl)cc(Cl)cc3Cl)[nH]c(C(F)(F)F)c1-2,,ClCCl,,BrB(Br)Br,,val
US20110112063A1,Cc1cc(Nc2nc(Nc3cc(C)c(C4CCNCC4)cc3F)ncc2Cl)n[nH]1.O=S1(=O)CC(Br)C1>>Cc1cc(Nc2nc(Nc3cc(C)c(C4CCN(C5CS(=O)(=O)C5)CC4)cc3F)ncc2Cl)n[nH]1,,CO,,,,val
US20160115158A1,COC(=O)c1cccc(S(=O)(=O)Cl)c1.COc1cc(Cl)nnc1N>>COC(=O)c1cccc(S(=O)(=O)Nc2nnc(Cl)cc2OC)c1,,CCOC(C)=O,COCCOC,Cl,[H-].[Na+],val
US20100105727A1,CC(C)N=C=O.OCC1CCNCC1>>CC(C)NC(=O)N1CCC(CO)CC1,,ClCCl,,,,val
US20060128734A1,C1CCNCC1.O=C(O)c1cc([N+](=O)[O-])cc(C(F)(F)F)c1>>O=C(c1cc([N+](=O)[O-])cc(C(F)(F)F)c1)N1CCCCC1,,CCCCCC,CCOC(C)=O,,,val
US20050014780A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=C(NCc1ccc(F)cc1)c1nc(Br)c2cccnc2c1O>>Cc1ccc(S(=O)(=O)Oc2c(C(=O)NCc3ccc(F)cc3)nc(Br)c3cccnc23)cc1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20120266768A1,CC(=O)c1cccc(N)c1.O=C(Cl)CCCl>>CC(=O)c1cccc(NC(=O)CCCl)c1,,CCOC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20150031668A1,CNOC.O=C(O)c1ncccc1Br>>CON(C)C(=O)c1ncccc1Br,,ClCCl,,Cl,O=C(n1ccnc1)n1ccnc1,val
US03985885,Nc1cc([N+](=O)[O-])ccc1S.O=C(O)c1cccnc1>>O=[N+]([O-])c1ccc2sc(-c3cccnc3)nc2c1,,ClC(Cl)Cl,,,,val
US20110312945A1,CCOC(=O)Cn1c(C)c(Cc2ccccc2S(=O)(=O)N2CCCC2)c2c1CCC(C)(C)C2>>Cc1c(Cc2ccccc2S(=O)(=O)N2CCCC2)c2c(n1CC(=O)O)CCC(C)(C)C2,,C1CCOC1,,O,[Na+].[OH-],val
US20100216794A1,Nc1ncc(Oc2ccccc2)cc1OCC1CCCC1.S=C(n1ccnc1)n1ccnc1.[NH4+]>>NC(=S)Nc1ncc(Oc2ccccc2)cc1OCC1CCCC1,,C1CCOC1,,O,,val
US20100087515A1,NC(=O)Nc1sc(-c2ccc(CN[C@H](C(=O)OC3CCCC3)c3ccccc3)cc2)cc1C(N)=O>>NC(=O)Nc1sc(-c2ccc(CN[C@H](C(=O)O)c3ccccc3)cc2)cc1C(N)=O,,C1CCOC1,,[Li+].[OH-],,val
US20110098425A1,COS(=O)(=O)OC.Oc1c(Br)cccc1Br>>COc1c(Br)cccc1Br,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20080200466A1,CC(Br)C(=O)OC(C)(C)C.O=C(COc1ccc(Cl)cc1Cc1cc(Cl)ccc1O)OCc1ccccc1>>CC(Oc1ccc(Cl)cc1Cc1cc(Cl)ccc1OCC(=O)OCc1ccccc1)C(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06204264B1,CN(C)C(=O)c1ccc(Cl)c([N+](=O)[O-])c1.CN(C)CCN>>CN(C)CCNc1ccc(C(=O)N(C)C)cc1[N+](=O)[O-],,CCOC(C)=O,,,,val
US20100048610A1,CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1Oc1ccnc(COC(C)=O)c1>>CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1Oc1ccnc(CO)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20060199821A1,CC(C)N1CCC(CN=Cc2ccccc2)CC1>>CC(C)N1CCC(CN)CC1,,CO,,Cl,O,val
US04775692,COC(=O)C(C)C.COP(C)(=O)OC>>COP(=O)(CC(=O)C(C)C)OC,,C1CCOC1,O,CC(=O)O,[Li]CCCC,val
US04286983,CCN(CC)C(=O)C(C)Nc1ccc(Cl)c(Cl)c1>>CCN(CC)CC(C)Nc1ccc(Cl)c(Cl)c1,,C1CCOC1,,O,[Na+].[OH-],val
US20030073836A1,Nc1cc(C(=O)NCc2ccc(N3CCCc4ccccc43)cc2)ncn1.O=C(Cl)c1ccccc1-c1ccc(C(F)(F)F)cc1>>O=C(NCc1ccc(N2CCCc3ccccc32)cc1)c1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)ncn1,,C1CCOC1,,CCN(CC)CC,,val
US20090247538A1,CC(C)(C)OC(=O)NC1CCNCC1.Clc1ncnc2nc[nH]c12>>CC(C)(C)OC(=O)NC1CCN(c2ncnc3[nH]cnc23)CC1,,CCCCO,,CCN(CC)CC,,val
US05141945,Cc1c2n(c3ccccc13)C(=O)C(C(O)c1nccn1C(c1ccccc1)(c1ccccc1)c1ccccc1)CC2>>Cc1c2n(c3ccccc13)C(=O)C(C(O)c1ncc[nH]1)CC2,,CC(=O)O,O,,,val
US20160039784A1,O=Cc1cc(Cl)ncc1Br.OB(O)c1ccccc1>>O=Cc1cc(Cl)ncc1-c1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20040138211A1,COC(=O)C(=Cc1ccc(OCCOc2ccc3ccccc3c2)cc1)C(=O)OC>>COC(=O)C(Cc1ccc(OCCOc2ccc3ccccc3c2)cc1)C(=O)OC,[Pd],C1COCCO1,CO,[H][H],,val
US20150133422A1,Fc1cc2[nH]cc(I)c2cc1F.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(c1ccccc1)n1cc(I)c2cc(F)c(F)cc21,,C1CCOC1,,[H-].[Na+],,val
US20020028835A1,CC(=O)c1ccc(Cl)c(Nc2ccccc2)c1.CS(=O)(=O)Cl>>CC(=O)c1ccc(Cl)c(NS(C)(=O)=O)c1,,ClCCl,c1ccncc1,,,val
US20060111375A1,CC(=O)c1ccc2ccccc2c1O.COc1cc2nccc(Cl)c2cc1OC>>COc1cc2nccc(Oc3c(C(C)=O)ccc4ccccc34)c2cc1OC,CN(C)c1ccncc1,Clc1ccccc1Cl,,O,,val
US20160221972A1,COC(=O)c1ccc2c(c1)CN(Cc1nc3ccccc3[nH]1)CC(=O)N2.NO>>O=C1CN(Cc2nc3ccccc3[nH]2)Cc2cc(C(=O)NO)ccc2N1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20150346226A1,COc1cc([N+](=O)[O-])c(OC)cc1CCN.COc1ccccc1C=O>>COc1cc([N+](=O)[O-])c(OC)cc1CCNCc1ccccc1OC,,ClCCCl,,O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20060293394A1,CC(C)Br.COc1ccc2c(c1O)CCCC2>>COc1ccc2c(c1OC(C)C)CCCC2,,CC(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030105074A1,COc1ccc(CNc2nnc(Cl)c3ccc(C#N)cc23)cc1Cl.COc1ccc(OB(O)O)cc1>>COc1ccc(-c2nnc(NCc3ccc(OC)c(Cl)c3)c3cc(C#N)ccc23)cc1.Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20040220216A1,CN1CCN(S(=O)(=O)c2ccc3c(c2)CCN3)CC1>>CN1CCN(S(=O)(=O)c2ccc3[nH]ccc3c2)CC1,O=[Mn]=O,ClCCl,,,,val
US20010025041A1,CC(=O)Oc1cccc(OCc2ccccc2)c1>>Oc1cccc(OCc2ccccc2)c1,,C1CCOC1,,Cl,[Na+].[OH-],val
US04005217,COC(=O)Nc1ccc(NC(=O)CN(C)C)c([N+](=O)[O-])c1>>COC(=O)Nc1ccc(NC(=O)CN(C)C)c(N)c1,O=[Pt],CO,,[H][H],,val
US20030114668A1,CC[C@@H]1COCC(=O)N1Cc1ccccc1>>CC[C@@H]1COCCN1Cc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20050124683A1,BrCc1ccccc1.Cc1ccc([N+](=O)[O-])c(C)c1C(=O)O>>Cc1ccc([N+](=O)[O-])c(C)c1C(=O)OCc1ccccc1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20020169189A1,COc1cc(Cl)cc(C(=O)N(C(C)C)C(C)C)c1>>CC(C)N(C(=O)c1cc(O)cc(Cl)c1)C(C)C,,ClCCl,,BrB(Br)Br,CO,val
US20130053366A1,CCOC(=O)Cl.Cc1ccc2c(c1)c1c(n2CC(O)c2ccncc2)CCNC1>>CCOC(=O)N1CCc2c(c3cc(C)ccc3n2CC(O)c2ccncc2)C1,,ClCCl,,CCN(CC)CC,,val
US20090221555A1,Clc1ncc(Cl)c(Cl)n1.N#CCCOc1cc(N2CCOCC2)ccc1[N+](=O)[O-]>>N#CCCOc1cc(N2CCOCC2)ccc1Nc1nc(Cl)ncc1Cl,[Pd],CCO,,CCN(CC)CC,O,val
US20140113877A1,CC(C)(C)OC(=O)N1CCC(n2c(=O)c3sc(-c4ccccc4)cc3n(Cc3ccccc3)c2=O)CC1.Cl>>Cl.O=c1c2sc(-c3ccccc3)cc2n(Cc2ccccc2)c(=O)n1C1CCNCC1,,C1COCCO1,,,,val
US04598082,CCCCCCCCBr.CCCCCCCCNc1ccncc1>>Br.CCCCCCCCN=c1ccn(CCCCCCCC)cc1,,CCOCC,,,,val
US20120010241A1,Cc1nn(-c2ccc(C#N)c(NCCF)c2)c2cccc(-c3cnc4ccccc4c3)c12.OO>>Cc1nn(-c2ccc(C(N)=O)c(NCCF)c2)c2cccc(-c3cnc4ccccc4c3)c12,,CS(C)=O,O,CCO,[Na+].[OH-],val
US20050215556A1,C=CCBr.O=[N+]([O-])c1cc(Br)cc(F)c1O>>C=CCOc1c(F)cc(Br)cc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130225620A1,CC(=O)c1cccc2c1ccn2S(=O)(=O)c1ccc(C)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c(C(C)O)cccc32)cc1,,CO,,[BH4-].[Na+],,val
US04883901,CC(=O)O.CC(=O)c1ccc(OC(C)C(=O)O)cc1.NO>>CC(=O)Nc1ccc(OC(C)C(=O)O)cc1,O=S(=O)(O)O,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20060194801A1,COC(=O)c1ccc(C#CC(C)(C)C)cc1OC>>COc1cc(C#CC(C)(C)C)ccc1C(=O)O,,CO,,[Na+].[OH-],,val
US20160168156A1,CCOC(=O)CP(=O)(OCC)OCC.O=Cc1cnn2ccc(N3CCCC3c3cncc(F)c3)nc12>>CCOC(=O)/C=C/c1cnn2ccc(N3CCCC3c3cncc(F)c3)nc12,,C1CCOC1,,[H-].[Na+],,val
US20070093526A1,Brc1cccc2cccnc12.CN(C)C=O>>O=Cc1cccc2cccnc12,,C1CCOC1,,[Li]C(C)CC,,val
US20100204208A1,CC(C)Nc1cc([N+](=O)[O-])ccc1OC(C)C.CI>>CC(C)Oc1ccc([N+](=O)[O-])cc1N(C)C(C)C,,CN(C)C=O,,[H-].[Na+],,val
US20040006066A1,Cc1cc(C)c(N2CCCc3c2[nH]n(C)c3=O)c(Cl)c1.O=P(Br)(Br)Br>>Cc1cc(C)c(N2CCCc3c2nn(C)c3Br)c(Cl)c1,,ClCCl,,,,val
US20040220403A1,COC(=O)c1c(OC)ccc([N+](=O)[O-])c1OC>>COC(=O)c1c(OC)ccc(N)c1OC,[Pd],C1CCOC1,CO,,,val
US05530119,O=[N+]([O-])c1ccc(CN2CCNCC2)cc1>>O=[N+]([O-])c1ccc(CN2CCNCC2)cc1,,[Na+],[OH-],Br,,val
US20140031351A1,CC(C)S(=O)(=O)c1ccc(Br)cc1[N+](=O)[O-]>>CC(C)S(=O)(=O)c1ccc(Br)cc1N,[Fe],C1CCOC1,CC(=O)O,,,val
US20080188531A1,CCOC(=O)CCN=C=O.Cc1nc(N)sc1-c1csc(CC#N)n1>>CCOC(=O)CCNC(=O)Nc1nc(C)c(-c2csc(CC#N)n2)s1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04973731,CC(C)(C)c1cc(O)cc(C(C)(C)C)c1.N#CCCCCCCBr>>CC(C)(C)c1cc(OCCCCCCC#N)cc(C(C)(C)C)c1,,CN(C)C=O,,[Na+].[OH-],,val
US20150073019A1,COC(OC)N(C)C.Cc1cccc(-c2cc(=O)n(-c3nc4ccccc4s3)[nH]2)c1>>Cc1cccc(C2=NN(c3nc4ccccc4s3)C(=O)C2=CN(C)C)c1,,C1CCOC1,,,,val
US20100069457A1,O=C(O)Cc1ccc(N2C(=O)c3c(c(OCC(F)F)c4ccccc4c3OCC(F)F)C2O)c(Cl)c1>>O=C(O)Cc1ccc(N2Cc3c(c(OCC(F)F)c4ccccc4c3OCC(F)F)C2=O)c(Cl)c1,,O=C(O)C(F)(F)F,,CC[SiH](CC)CC,,val
US20020065420A1,CC(C)COC(=O)Cl.Cl[Mg]c1ccccc1.c1ccncc1>>CC(C)COC(=O)N1C=CC(c2ccccc2)C=C1,[Cu]I,C1CCOC1,C1CCOC1,O=S(=O)(O)O,,val
US20080269335A1,CCOC(=O)COc1ccc(Cl)cc1C1CCCCCC1>>O=C(O)COc1ccc(Cl)cc1C1CCCCCC1,,CO,,Cl,[Na+].[OH-],val
US20120015950A1,CNC(=O)c1cc(COC(=O)NCCC2(C)CCNCC2)on1.FC(F)(F)c1ccnc(Cl)n1>>CNC(=O)c1cc(COC(=O)NCCC2(C)CCN(c3nccc(C(F)(F)F)n3)CC2)on1,,CC#N,,CCN(C(C)C)C(C)C,Cl,val
US20110190342A1,COc1cccc(CC(N)C(=O)O)c1.O=C(O)c1cc2cc(Cl)ccc2nc1Cl>>COc1cccc(CC(Nc2nc3ccc(Cl)cc3cc2C(=O)O)C(=O)O)c1,,CS(C)=O,,,,val
US20090257979A1,CCOC(=O)C1C(=O)N(CCC(C)C)c2nccn2C1=O.Nc1ccccc1S(N)(=O)=O>>CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3ccccc3N2)c(O)n2ccnc12,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US05496946,CCOC(=O)CC[C@H](NC(=O)c1ccc(CCCC(c2c(N)nc(N)nc2N)C(OC)OC)cc1)C(=O)OCC>>CCOC(=O)CC[C@H](NC(=O)c1ccc(CCCc2c[nH]c3nc(N)nc(N)c23)cc1)C(=O)OCC,,CCO,O,Cl,N,val
US20150038438A1,COC(=O)C(C(=O)OC)C(=O)OC.COc1ccc(CN=C2CCCOc3cc4c(cc32)cc(CO[Si](C)(C)C(C)(C)C)n4C)c(OC)c1>>COC(=O)c1c(O)c2c(n(Cc3ccc(OC)cc3OC)c1=O)-c1cc3cc(CO[Si](C)(C)C(C)(C)C)n(C)c3cc1OCC2,,c1ccc(Oc2ccccc2)cc1,,,,val
US20040034232A1,BrBr.Cl.Nc1nc(-c2ccc(NC(=O)CN(C(=O)c3ccc(F)cc3)c3ccc(F)cc3)cc2)cs1>>Cl.Nc1nc(-c2ccc(NC(=O)CN(C(=O)c3ccc(F)cc3)c3ccc(F)cc3)cc2)c(Br)s1,,CC(=O)O,O,,,val
US20050261291A1,CC1(C)C=C(c2c(F)cccc2[N+](=O)[O-])CC(C)(C)C1>>CC1(C)C=C(c2c(N)cccc2F)CC(C)(C)C1,[Fe],CCO,,O,[Cl-].[NH4+],val
US20120165352A1,Nc1ccc(OCc2ccccn2)c(Cl)c1.O=[N+]([O-])c1ccc2ncnc(Cl)c2c1>>O=[N+]([O-])c1ccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2c1,,CC(C)O,,,,val
US20140315888A1,CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc(Br)cc3c3cccn23)C1>>CNC1CN(c2nc3ncc(Br)cc3c3cccn23)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050020604A1,CC(C)(C)OC(=O)N1CCN(c2cnc(F)c(OCc3cccc(Cl)c3)n2)CC1.O=CO>>Fc1ncc(N2CCNCC2)nc1OCc1cccc(Cl)c1.O=CO,,O=CO,,,,val
US20070037812A1,CCOC(=O)CCc1ccc(Oc2cc(C)cc(Oc3ccc(C(F)(F)F)cc3Oc3ccccc3)c2)cc1C>>Cc1cc(Oc2ccc(CCC(=O)O)c(C)c2)cc(Oc2ccc(C(F)(F)F)cc2Oc2ccccc2)c1,,CCO,O,Cl,[Na+].[OH-],val
US20060183736A1,CC(C)C(=O)OC(=O)C(C)C.CS(=O)(=O)c1ccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1>>CC(C)C(=O)Oc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3ccc(S(C)(=O)=O)cc3)ccc2c1,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US20150291572A1,CC1(S(=O)(=O)c2cccc(C(F)(F)F)c2)CCOC(c2ccc(Br)nc2)C1.CN>>CNc1ccc(C2CC(C)(S(=O)(=O)c3cccc(C(F)(F)F)c3)CCO2)cn1,[Cu]I,CN(C)C=O,,CO,O=C([O-])[O-].[K+].[K+],val
US20100029688A1,CC(C)(C)OC(=O)N1CCC(C2CCN(c3cc(Cl)ncn3)CC2)CC1.OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC(C2CCN(c3cc(OCc4ccccc4)ncn3)CC2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20130303471A1,CC(=O)OC[C@H]1O[C@@H](Oc2n[nH]c(C(C)C)c2Cc2ccc(/C=C/CCOS(C)(=O)=O)cc2C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.CC(C)(C)OC(=O)N1CCCC2(CNC2)C1>>CC(=O)OC[C@H]1O[C@@H](Oc2n[nH]c(C(C)C)c2Cc2ccc(/C=C/CCN3CC4(CCCN(C(=O)OC(C)(C)C)C4)C3)cc2C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,CC#N,,CCN(C(C)C)C(C)C,,val
US08273766B2,C1CCOC1.CCOC(=O)Nc1ccc(CNCCN2Cc3ccc(F)cc3CC2Cc2ccc(F)cc2)cc1>>O=C(O)CNc1ccc(CNCCN2Cc3ccc(F)cc3CC2Cc2ccc(F)cc2)cc1,,O,,Cl,[Li+].[OH-],val
US04155913,CC(O)c1nnc2n1-c1sc(Cl)cc1C(c1ccccc1Cl)=NC2>>CC(=O)c1nnc2n1-c1sc(Cl)cc1C(c1ccccc1Cl)=NC2,,Cc1ccccc1,,,,val
US04782050,Cc1nc2ccncc2n1C.O=[Se]=O>>Cn1c(C=O)nc2ccncc21,,C1COCCO1,,,,val
US20120046267A1,COCc1nc2ccccc2s1.O=[N+]([O-])O>>COCc1nc2ccc([N+](=O)[O-])cc2s1,,O=S(=O)(O)O,,,,val
US20140148468A1,CC(C)CCN.O=C(O)c1ncccc1F>>CC(C)CCNC(=O)c1ncccc1F,,CN(C)C=O,,CN1CCOCC1,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20080009530A1,CCOC(=O)/C=C/c1cc(C(C)(C)C)nn1Cc1ccc(C(F)(F)F)cc1Cl>>CC(C)(C)c1cc(/C=C/C(=O)O)n(Cc2ccc(C(F)(F)F)cc2Cl)n1,,CCO,,C1CCOC1,[Na+].[OH-],val
US20110059951A1,Cc1c(Cl)ncnc1N1CCC(C(CC#N)n2cc(-c3ncnc4[nH]ccc34)cn2)CC1.Nc1ccccc1F>>Cc1c(Nc2ccccc2F)ncnc1N1CCC(C(CC#N)n2cc(-c3ncnc4[nH]ccc34)cn2)CC1,,O,,,,val
US05840917,CCI.C[Si](C)(C)c1occc1C(=O)O>>CCOC(=O)c1ccoc1[Si](C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120077781A1,CC(=O)Nc1cc(Cl)c(C)cc1[N+](=O)[O-]>>Cc1cc([N+](=O)[O-])c(N)cc1Cl,,CO,O,C[O-].[Na+],,val
US20100068178A1,COC(=O)c1sc(C(=O)OC)c([N+](=O)[O-])c1O.COS(=O)(=O)OC>>COC(=O)c1sc(C(=O)OC)c([N+](=O)[O-])c1OC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140134110A1,CC(=O)O.CC1(C)CC(=O)CC(=O)C1>>CC(O)=C1C(=O)CC(C)(C)CC1=O,CN(C)c1ccncc1,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US20150051208A1,CC(C)(C)OC(=O)Nc1ccc(N)c(NCc2ccccc2)c1.Cc1cc(C(=O)O)cn(C)c1=O>>Cc1cc(C(=O)Nc2ccc(NC(=O)OC(C)(C)C)cc2NCc2ccccc2)cn(C)c1=O,,C1CCOC1,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05968875,C1CCOC1.CNC(=O)C(=NOC)c1cccc(Cl)c1CO.O=C(O)c1cnc(Cl)c(Cl)c1>>CNC(=O)C(=NOC)c1cccc(Cl)c1COc1ncc(C(=O)OC(C)(C)C)cc1Cl,,C1CCOC1,,O,[H-].[Na+],val
US20160264567A1,CC(C)(C)OC(=O)N(Cc1cc(-c2cnc(C(F)(F)F)nc2)ncc1F)C(=O)OC(C)(C)C>>NCc1cc(-c2cnc(C(F)(F)F)nc2)ncc1F,,ClCCl,,Cl,,val
US20010007873A1,Brc1cccc(OCc2ccccc2)c1.O=C1CCCC1>>OC1(c2cccc(OCc3ccccc3)c2)CCCC1,,CCOCC,,[Mg],[Cl-].[NH4+],val
US20130059883A1,N#Cc1cccc(C(=NCC2(c3nc(-c4ccccc4)cs3)CCOCC2)C(F)(F)F)c1>>N#Cc1cccc(C(NCC2(c3nc(-c4ccccc4)cs3)CCOCC2)C(F)(F)F)c1,,CO,O,[BH4-].[Na+],,val
US20060194843A1,COc1cccc(C(=O)O)c1F.Nc1c[nH]nc1C(=O)Nc1ccc(F)cc1>>COc1cccc(C(=O)Nc2c[nH]nc2C(=O)Nc2ccc(F)cc2)c1F,,CS(C)=O,O,ClCCCl,On1nnc2ccccc21,val
US20030130277A1,Cn1ncc2[nH]c3ccc(C(=O)c4ccccc4)cc3c(=O)c21>>Cn1ncc2[nH]c3ccc(C(O)c4ccccc4)cc3c(=O)c21,,O=P(Cl)(Cl)Cl,,,,val
US20020107278A1,O=C(c1ccccc1)N1CCc2[nH]c3cccc(-c4ccccc4F)c3c2CC1>>Fc1ccccc1-c1cccc2[nH]c3c(c12)CCN(Cc1ccccc1)CC3,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04744812,COC(C)=S.O=[N+]([O-])c1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1CCl>>COC(=S)CCc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],,C1CCOC1,,[H-].[Na+],,val
US20150344407A1,O=[N+]([O-])c1ccc(/C(=C/CO)c2ccccc2)cc1>>O=C/C=C(\c1ccccc1)c1ccc([N+](=O)[O-])cc1,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US05773530,CCOC(=O)C[C@H]1CCCC[C@H]1n1nc(-c2c(-c3ccccc3)nn3ccccc23)ccc1=O>>O=C(O)C[C@H]1CCCC[C@H]1n1nc(-c2c(-c3ccccc3)nn3ccccc23)ccc1=O,,C1COCCO1,,[Na+].[OH-],,val
US20110266526A1,Brc1cc2ccccc2c2ccccc12.COS(=O)(=O)OC>>Cc1cc2ccccc2c2ccccc12,,CCOCC,,Cl,[Li]CCCC,val
US04521413,CCON=C(C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CCl)CS(=O)[C@H]12)c1nsc(N)n1.CN(C)c1cccnc1>>CCON=C(C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(C[n+]3cccc(N(C)C)c3)CS(=O)[C@H]12)c1nsc(N)n1.[Cl-],,C1CCOC1,,,,val
US20150252038A1,CS(N)(=O)=O.N#Cc1c(Cl)cc(Cl)cc1CN1CCC(COc2cc(F)c(C(=O)O)cc2C2CC2)CC1>>CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3cc(Cl)cc(Cl)c3C#N)CC2)cc1F,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20150291595A1,COc1c(F)cccc1B(O)O.Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(Br)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12>>COc1c(F)cccc1-c1cn(COCC[Si](C)(C)C)c2ncnc(N[C@@H](C)c3nn4ccc(C)c4c(=O)n3-c3ccccc3)c12,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US04666915,CCOC(=O)c1cnc(Nc2cccc(OC)c2)[nH]c1=O>>COc1cccc(Nc2ncc(C(=O)O)c(=O)[nH]2)c1,,CC(=O)O,,O,[Na+].[OH-],val
US20040048880A1,COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1O.O[C@@H]1CCOC1>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1O[C@H]1CCOC1,,CC#N,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080125436A1,CN=C=S.Cn1ccc(C(=O)NN)cc1=O>>Cn1c(S)nnc1-c1ccn(C)c(=O)c1,,CO,O,[Na+].[OH-],,val
US20080300242A1,C1CCN(C2CCNCC2)CC1.COc1cc([N+](=O)[O-])c(OC)cc1Cl>>COc1cc([N+](=O)[O-])c(OC)cc1N1CCC(N2CCCCC2)CC1,,CS(C)=O,,O,O=C([O-])[O-].[K+].[K+],val
US04185118,CCCCC/C=C\C/C=C\CCCCCCCC(=O)O.NC1CCc2ccccc21>>CCCCC/C=C\C/C=C\CCCCCCCC(=O)NC1CCc2ccccc21,,ClCCl,,CCN(CC)CC,CCOC(=O)Cl,val
US20140323475A1,COC(=O)c1cccc(N)c1NCCO>>COC(=O)c1cccc2c1NCCN2,,C1CCOC1,,CS(=O)(=O)Cl,,val
US05665718,CCOC(=O)c1ncn2c1[C@@H]1CCN1C(=O)c1cc(F)ccc1-2>>O=C(O)c1ncn2c1[C@@H]1CCN1C(=O)c1cc(F)ccc1-2,,CCO,,Cl,[Na+].[OH-],val
US05302590,CCOC(=O)c1cc(CCc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)ccc1CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1.O>>Cc1nnc2n1-c1sc(CCc3ccc(CC(=O)Nc4cccc(/C=C/c5nc(C6CCC6)cs5)c4)c(C(=O)O)c3)cc1C(c1ccccc1Cl)=NC2.O,,CC(=O)O,,CCO,[Na+].[OH-],val
US04597902,CC(C)NCCSc1ccc(Cl)cc1.O=C(Cl)Oc1ccccc1>>CC(C)N(CCSc1ccc(Cl)cc1)C(=O)Oc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20130059832A1,CS(=O)(=O)Cl.Cc1ccc(-c2noc(CO)n2)cc1NC(=O)c1cnc2ccccn12>>Cc1ccc(-c2noc(COS(C)(=O)=O)n2)cc1NC(=O)c1cnc2ccccn12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US08507672B2,CS(=O)(=O)N=C(Nc1cccc(Br)c1)Oc1ccccc1.Cc1c[nH]c2ncnc(N3CCN[C@@H](C)C3)c12>>Cc1c[nH]c2ncnc(N3CCN(C(=NS(C)(=O)=O)Nc4cccc(Br)c4)[C@@H](C)C3)c12,,CC#N,,CCN(CC)CC,,val
US20100256097A1,CC(C)(O)c1ccc(-c2cc(C(N)=O)c(Nc3cccc(CO)n3)s2)c(F)c1>>CC(C)(O)c1ccc(-c2cc(C(N)=O)c(Nc3cccc(C=O)n3)s2)c(F)c1,,CS(C)=O,,,,val
US20140221387A1,Nc1ccccn1.O=C(Nc1cccnc1)c1cc(-c2ccco2)nc2ccc(Br)cc12>>O=C(Nc1cccnc1)c1cc(-c2ccco2)nc2ccc(Nc3ccccn3)cc12,,CCOC(C)=O,Cc1ccccc1,,,val
US20120295903A1,Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCNC(=O)OC(C)(C)C)c2cc1OC1CCCC1>>Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCN)c2cc1OC1CCCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05332743,CC(=O)OCc1cccc(CN2CCN(c3ccccc3OC(C)C)CC2)c1>>CC(C)Oc1ccccc1N1CCN(Cc2cccc(CO)c2)CC1,,CC(C)O,CO,[K+].[OH-],,val
US20090018103A1,CC(C)(C)[Si](C)(C)Cl.Oc1ccccc1Br>>CC(C)(C)[Si](C)(C)Oc1ccccc1Br,,CN(C)C=O,,O,c1c[nH]cn1,val
US04788185,Nc1ncccc1OCc1ccccc1.O=CCBr>>c1ccc(COc2cccn3ccnc23)cc1,,C1CCOC1,,O=C([O-])O.[Na+],,val
US05192781,CCCCCc1nc(C)sc1Cc1ccc([N+](=O)[O-])cc1>>CCCCCc1nc(C)sc1Cc1ccc(N)cc1,,CCO,,,,val
US20080027112A1,CNC.COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCBr>>COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCN(C)C,,CS(C)=O,,,,val
US20130116235A1,Cn1cc(Br)nc(Br)c1=O.Nc1cccc(N)c1>>Cn1cc(Br)nc(Nc2cccc(N)c2)c1=O,,CC(C)O,,CCN(CC)CC,,val
US20040242572A1,CS(=O)(=O)OCc1ccc(CCNC(=O)c2ccc(-c3ccc(Cl)cc3)cc2)cc1.NCC1CC1>>O=C(NCCc1ccc(CNCC2CC2)cc1)c1ccc(-c2ccc(Cl)cc2)cc1,,CCN(CC)CC,,,,val
US05554607,CCNCC(=O)O.Cc1ccc(N=C=S)c(Cl)c1>>CCN1CC(=O)N(c2ccc(C)cc2Cl)C1=S,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20150099730A1,CC(C)(C)OC(=O)N1CC[C@@H](CI)C1.O=C1NC(c2ccc(Br)cc2)=NC12CCN(Cc1ccccc1)CC2>>CC(C)(C)OC(=O)N1CC[C@@H](CN2C(=O)C3(CCN(Cc4ccccc4)CC3)N=C2c2ccc(Br)cc2)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US03991071,CCCNCc1ccc(Cl)cc1.O=C(Cl)Cl>>CCCN(Cc1ccc(Cl)cc1)C(=O)Cl,,CCOC(C)=O,,,,val
US20140094462A1,C=CC[C@@H](C)C(=O)O.CNC[C@H](NC(=O)OC(C)(C)C)c1ccccc1>>C=CC[C@@H](C)C(=O)N(C)C[C@H](NC(=O)OC(C)(C)C)c1ccccc1,,CN(C)C=O,,,,val
US20140142114A1,C1CNCCN1.Cc1cc(Cl)nc2ccccc12>>Cc1cc(N2CCNCC2)nc2ccccc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06391887B1,C1=C(N2CCOCC2)CCC1.O=C=Nc1ccc(F)cc1>>O=c1[nH]c2ccc(F)cc2c2c1CCC2,,ClC(Cl)Cl,,,,val
US20120108597A1,COC(=O)CN.Nc1cnccc1C(=O)O>>COC(=O)CNC(=O)c1ccncc1N,,c1ccncc1,,Cl,O=C(n1ccnc1)n1ccnc1,val
US20130065894A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2cc(Cl)nc3c2c(/C=C/c2ccc(Cl)cc2)nn3C2CCCCO2)CC1.OB(O)c1ccc(O)cc1>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cc(-c3ccc(O)cc3)nc3c2c(/C=C/c2ccc(Cl)cc2)nn3C2CCCCO2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130338124A1,Cn1c(=O)c2c(Cl)n(Cc3ccc(-c4ccncc4)cc3)nc2n(CC(C)(C)C)c1=O.Oc1ccccc1>>Cn1c(=O)c2c(Oc3ccccc3)n(Cc3ccc(-c4ccncc4)cc3)nc2n(CC(C)(C)C)c1=O,,CN(C)C=O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20110230458A1,CC1(C)OB(c2cn[nH]c2)OC1(C)C.CCCCc1nnc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1-c1ccc(OC2CCCCC2)c(Br)c1>>CCCCc1nnc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1-c1ccc(OC2CCCCC2)c(-c2cn[nH]c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US05021441,FC(F)(F)CCCCCCCCCBr.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>FC(F)(F)CCCCCCCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-],,CC#N,,,,val
US04766131,COc1ccc2c(c1)CCN=C2C.Cl>>COc1ccc2c(c1)CCNC2C.Cl,,CO,,Cl,[Na+].[OH-],val
US20100021423A1,COc1c(COc2ccc([N+](=O)[O-])cc2)cc(Br)cc1C(C)(C)C>>COc1c(COc2ccc(N)cc2)cc(Br)cc1C(C)(C)C,[Fe],CO,O,[Cl-].[NH4+],,val
US20110319392A1,N#CC1CCNCC1.O=[N+]([O-])c1ccc(Cl)nc1>>N#CC1CCN(c2ccc([N+](=O)[O-])cn2)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20090221645A1,CC(C)C(Br)C(=O)c1ccc(F)c2ccccc12.S=C1NCCN1>>CC(C)C1=C(c2ccc(F)c3ccccc23)N2CCN=C2S1,,CCO,,CC(=O)O,,val
US20160176843A1,COC(=O)c1ccc(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)OC(C)(C)C)CC2)cc1>>CC(C)(C)OC(=O)N1CCC(N(CCc2ccc(Cl)cc2)Cc2ccc(C(=O)O)cc2)CC1,,CO,,Cl,[Na+].[OH-],val
US20100120841A1,Cc1cccc2c1CCC[C@H]2N1CCC(Nc2ccccc2N)CC1.O=C(n1ccnc1)n1ccnc1>>Cc1cccc2c1CCC[C@H]2N1CCC(n2c(=O)[nH]c3ccccc32)CC1,,C1CCOC1,,O,,val
US20160120841A1,COC(=O)c1cccc([C@H]2C[C@@H](NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c3ccc(O)cc3O2)c1.COCCO>>COCCOc1ccc2c(c1)O[C@@H](c1cccc(C(=O)OC)c1)C[C@H]2NC(=O)C1(c2ccc3c(c2)OC(F)(F)O3)CC1,,ClCCl,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20160229816A1,CCC(O)c1cccc(C(C)(C)O[SiH2]C(C)(C)C)n1.FC(F)(F)c1ccc(CBr)cc1>>CCC(OCc1ccc(C(F)(F)F)cc1)c1cccc(CO)n1,,CN(C)C=O,,[H-].[Na+],,val
US06586447B1,CN(C)S(=O)(=O)c1ccc(CN2C(=O)C(C(=O)OC(C)(C)C)(C(=O)OC(C)(C)C)c3ccc(Br)cc32)cc1>>CN(C)S(=O)(=O)c1ccc(CN2C(=O)Cc3ccc(Br)cc32)cc1,,O=C(O)C(F)(F)F,,,,val
US05308857,CSC(=NC#N)NCc1ccc(-c2csc(N=C(N)N)n2)o1.NCCO>>N#CN=C(NCCO)NCc1ccc(-c2csc(N=C(N)N)n2)o1,,CN(C)C=O,,,,val
US20090029976A1,COc1ccc2oc(C(=O)O)cc2c1.C[C@H]1CNC[C@@H](C)O1>>COc1ccc2oc(C(=O)N3C[C@H](C)O[C@H](C)C3)cc2c1,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20110136764A1,CCOP(=O)(Cc1cccc([N+](=O)[O-])c1)OCC>>CCOP(=O)(Cc1cccc(N)c1)OCC,[Pd],CO,,,,val
US20020156054A1,CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(c2ccc(Cl)cc2)=CCC3(C)C)cc1>>CC1(C)CC=C(c2ccc(Cl)cc2)c2cc(C=Cc3ccc(C(=O)O)cc3)ccc21,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US04788206,COc1ccc(/C(=C\C=C\C(=O)O)C2CC2)cc1.O=[N+]([O-])c1ccc(O)cc1>>COc1ccc(/C(=C\C=C\C(=O)Oc2ccc([N+](=O)[O-])cc2)C2CC2)cc1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20030181726A1,COc1ccc(C(CCN(Cc2ccccc2)C[C@H](O)COc2ccc(OCc3ccccc3)c(N)c2)c2ccc(OC)cc2)cc1.CS(=O)(=O)Cl>>COc1ccc(C(CCNC[C@H](O)COc2ccc(O)c(NS(C)(=O)=O)c2)c2ccc(OC)cc2)cc1,,ClCCl,,c1ccncc1,,val
US06734206B1,COC(=O)COCCCCN1C(=O)CC[C@@H]1/C=C/C(=O)Cc1cccc(Cl)c1>>COC(=O)COCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1cccc(Cl)c1,CO,ClCCl,,Cl,[BH4-].[Na+],val
US20160024072A1,CN(C)c1cccc(Cc2ccc(Cl)cc2)c1.O=C1CCC(=O)N1Br>>CN(C)c1ccc(Br)c(Cc2ccc(Cl)cc2)c1,,O,,ClCCl,,val
US20040110945A1,CCOC(=O)Cc1ccc(Nc2nc3ccccc3o2)cc1>>O=C(O)Cc1ccc(Nc2nc3ccccc3o2)cc1,,C1CCOC1,Cl,[Na+].[OH-],,val
US20100105642A1,COC(=O)Cc1ccc(F)c(-c2cnn(C)c2)c1>>Cn1cc(-c2cc(CCO)ccc2F)cn1,,ClCCl,,CC(C)C[Al+]CC(C)C.[H-],,val
US20030069297A1,Cc1[nH]c(C=O)c(C)c1C(=O)NCCn1ccnn1.O=C1Cc2c(cccc2-c2cccc(Cl)c2)N1>>Cc1[nH]c(C=C2C(=O)Nc3cccc(-c4cccc(Cl)c4)c32)c(C)c1C(=O)NCCn1ccnn1,C1CCNCC1,CCO,,,,val
US06809097B1,COc1cc2nccc(Nc3ccc(Cl)cc3F)c2cc1C(=O)O.NCCCN1CCOCC1>>COc1cc2nccc(Nc3ccc(Cl)cc3F)c2cc1C(=O)NCCCN1CCOCC1,,CN(C)C=O,,CCN=C=NCCCN(C)C,Cl,val
US06479508B1,C=CC(=O)OC.CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O.O=C(O)[C@H](Cc1ccc(O)cc1)NI.O=C(O)c1ccc2c(c1)nc(-c1ccoc1)n2C1CCCCC1>>NC(=O)[C@H](Cc1ccc(O)c(/C=C/C(=O)O)c1)NC(=O)c1ccc2c(c1)nc(-c1ccoc1)n2C1CCCCC1,,C1COCCO1,,Cl,,val
US20130137675A1,CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ccnn1-c1ccccc1>>CC(C)(C)OC(=O)Nc1ccnn1-c1ccccc1,,CO,,[Na+].[OH-],,val
US05889026,Cc1ccc(CC2(O)CCN(CCO)CC2)cc1.O=C(O)c1ccc(OCc2ccccc2)cc1>>Cc1ccc(CC2(O)CCN(CCOC(=O)c3ccc(OCc4ccccc4)cc3)CC2)cc1,,CN(C)C=O,ClCCl,O,O=C(n1ccnc1)n1ccnc1,val
US05843942,CCN(Cc1ccccc1OCc1ccccc1)c1ccc(C(=O)OC)cc1>>CCN(Cc1ccccc1OCc1ccccc1)c1ccc(C(=O)O)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US05919932,CN1C2C=C(c3cccc([N+](=O)[O-])c3)CC1CC2>>CN1C2CCC1CC(c1cccc(N)c1)C2,,CCO,,,,val
US20060235029A1,CCN(CC)CCCNc1nc(-c2cccc(C(=O)O)c2)c2ccc(=O)n(-c3c(F)cccc3F)c2n1.Nc1ccc(F)cc1>>CCN(CC)CCCNc1nc(-c2cccc(C(=O)Nc3ccc(F)cc3)c2)c2ccc(=O)n(-c3c(F)cccc3F)c2n1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130131017A1,C/C(=N\O)c1ccc2c(c1)B(O)OC2(C)C>>CC(N)c1ccc2c(c1)B(O)OC2(C)C,[Zn],CC(=O)O,,,,val
US20110130398A1,CC(C)(C)[Si](C)(C)OCCBr.COc1cc(O)ccc1[N+](=O)[O-]>>COc1cc(OCCO[Si](C)(C)C(C)(C)C)ccc1[N+](=O)[O-],,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20090209607A1,CCCc1cnn(C)c1-c1cc(C(=O)O)sc1C.N[C@@H](Cc1ccccc1C(F)(F)F)CN1C(=O)c2ccccc2C1=O>>CCCc1cnn(C)c1-c1cc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)sc1C,,ClCCl,,CCN(C(C)C)C(C)C,Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F,val
US06350749B1,Cc1ccc(S(=O)(=O)NNC2=CC(=O)CC(c3ccccc3Cl)C2)cc1.O=C(CBr)c1ccccc1>>O=C1CC(c2ccccc2Cl)Cc2nncc(-c3ccccc3)c21,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20130338140A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNC[C@H](O)c1ccc(C(F)(F)F)c(F)c1>>CN(C[C@H](O)c1ccc(C(F)(F)F)c(F)c1)C(=O)OC(C)(C)C,,C1CCOC1,O,O=C([O-])[O-].[K+].[K+],,val
US20100204227A1,CC(C)(C)[Si](C)(C)Cl.Cc1cc([N+](=O)[O-])ccc1O>>Cc1cc([N+](=O)[O-])ccc1O[Si](C)(C)C(C)(C)C,,CN(C)C=O,,,,val
US20100113417A1,COC(=O)CCC1(CCC(=O)OC)CCN(C(=O)OC(C)(C)C)CC1>>COC(=O)C1CC2(CCC1=O)CCN(C(=O)OC(C)(C)C)CC2,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20020169191A1,CC(C)(C)OC(=O)c1ccc(N2C[C@H](CN)OC2=O)cc1F.CCSC(C)=S>>CC(=S)NC[C@H]1CN(c2ccc(C(=O)OC(C)(C)C)c(F)c2)C(=O)O1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US04776929,CC(C)OC(=O)[O-].C[N+](C)(C)C>>C[N+](C)(C)C.O=C([O-])O,,O,,,,val
US20040260088A1,CN.N#Cc1ccc(Cl)cc1Oc1ccc(C=O)c2ccccc12.O=C(O)/C=C/C(=O)O>>CNCc1ccc(Oc2cc(Cl)ccc2C#N)c2ccccc12.O=C(O)/C=C/C(=O)O,,CC(=O)O,CO,[BH3-]C#N.[Na+],,val
US20140255381A1,COC(=O)CC1CN2CCC1CC2>>O=C(O)CC1CN2CCC1CC2,,Cl,,,,val
US20120225888A1,COC(=O)C(OC(C)(C)C)c1c(C)nc2c(C)c(-c3ccccc3)nn2c1-c1cc(F)c2c(c1C)CCCO2.O=C1CCC(=O)N1Br>>COC(=O)C(OC(C)(C)C)c1c(C)nc2c(Br)c(-c3ccccc3)nn2c1-c1cc(F)c2c(c1C)CCCO2,,CC#N,,,,val
US20150299194A1,CC(C)(C)OC(=O)NCCCCCC(=O)O.CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)OCCN>>CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)OCCNC(=O)CCCCCNC(=O)OC(C)(C)C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20120122843A1,Cc1c[nH]cn1.N#Cc1nc(N)ccc1Br>>Cc1cn(-c2ccc(N)nc2C#N)cn1,I[Cu]I,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110245353A1,CCOC=C(C(=O)OCC)C(=O)OCC.COc1ccc(N)cc1>>CCOC(=O)c1cnc2ccc(OC)cc2c1O,,c1ccc(Oc2ccccc2)cc1,,,,val
US20120245163A1,CC(=O)OC(C)=O.Cc1nc(N)cc2ccccc12>>CC(=O)Nc1cc2ccccc2c(C)n1,,ClCCl,,CCN(CC)CC,,val
US20030050310A1,CC1CCNCC1.O=C(CC(Cc1ccccc1)S(=O)(=O)Cl)OCc1ccccc1>>CC1CCN(S(=O)(=O)C(CC(=O)OCc2ccccc2)Cc2ccccc2)CC1,,ClCCl,,,,val
US20100104659A1,C1CCNC1.CN(CCCl)C(=O)N1N=C2c3cc(F)ccc3OCC2C1c1ccccc1>>CN(CCN1CCCC1)C(=O)N1N=C2c3cc(F)ccc3OCC2C1c1ccccc1,,ClCCl,,Cl,,val
US20040127426A1,CCCCC(NC(=O)OC(C)(C)C)C(O)C1(c2ccccc2)SCCCS1>>CCCCC(N)[C@H](O)C1(c2ccccc2)SCCCS1,,C1COCCO1,Cc1ccccc1,Cl,,val
US20110152296A1,CCOC(=O)c1c(Cl)nc2cccnc2c1Cl.OB(O)c1cccc(F)c1>>CCOC(=O)c1c(-c2cccc(F)c2)nc2cccnc2c1Cl,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC#N,,O,O=C([O-])[O-].[Na+].[Na+],val
US20090275606A1,C=CCC1(S(=O)(=O)n2c(=O)n(-c3ccc(Br)cc3F)c3c(F)c(=O)n4c(c32)CCC4)CC1>>C=CCC1(S(=O)(=O)Nc2c(Nc3ccc(Br)cc3F)c(F)c(=O)n3c2CCC3)CC1,,C1CCOC1,,,,val
US20110092539A1,N[C@@H]1Cc2ccc(Cn3cc(CO)c(C(F)(F)F)n3)cc2C1.O=S(=O)(Cl)c1ccccc1Cl>>O=S(=O)(N[C@@H]1Cc2ccc(Cn3cc(CO)c(C(F)(F)F)n3)cc2C1)c1ccccc1Cl,,C1CCOC1,CS(C)=O,CCN(CC)CC,,val
US20050272778A1,BrC(Br)(Br)Br.O=C1CC(c2ccc(CO)cc2Br)S(=O)(=O)N1>>O=C1CC(c2ccc(CBr)cc2Br)S(=O)(=O)N1,,C1COCCO1,CC#N,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20150065477A1,CCOC(=O)c1cccnc1-n1ccc(CCl)n1.FC1(F)CCNCC1>>CCOC(=O)c1cccnc1-n1ccc(CN2CCC(F)(F)CC2)n1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20150361098A1,COc1cccc2c1nc(N)n1nc(CC(C)OS(=O)(=O)c3ccc(C)cc3)nc21.Cc1nc2c(o1)CCNC2>>COc1cccc2c1nc(N)n1nc(CC(C)N3CCc4oc(C)nc4C3)nc21,,C1COCCO1,,CCN(C(C)C)C(C)C,,val
US05149357,COc1cc(OC)nc(S(C)(=O)=O)n1.O=C(O)c1c(O)cccc1-c1ccccc1>>COc1cc(OC)nc(Oc2cccc(-c3ccccc3)c2C(=O)O)n1,,C1CCOC1,,[H-].[Na+],,val
US20150175540A1,O=C1c2c(ccc(OCc3ccccc3)c2F)CN1C[C@@H]1CC[C@@H](CO)CC1>>O=C1c2c(ccc(O)c2F)CN1C[C@@H]1CC[C@@H](CO)CC1,[Pd],C1CCOC1,,[H][H],,val
US20050137212A1,COc1ccc(C=O)cc1C.C[N+](=O)[O-]>>COc1ccc(/C=C/[N+](=O)[O-])cc1C,,CO,O,Cl,[Na+].[OH-],val
US05461060,CSCCl.Cc1c(-c2ccccc2)[nH]c(=S)[nH]c1=O>>CSCn1c(-c2ccccc2)c(C)c(=O)[nH]c1=S,,CN(C)C=O,,CCN(CC)CC,,val
US20060128712A1,C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)O)C(F)(F)F.c1ccc2c(N3CCNCC3)nsc2c1>>C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2nsc3ccccc23)CC1)C(F)(F)F,,CC#N,,CCOC(C)=O,Cl,val
US06306887B1,CCOC(=O)CC(=O)c1cc(C(CC(C)C)NC(=O)OC(C)(C)C)no1.Cl>>CCOC(=O)CC(=O)c1cc(C(N)CC(C)C)no1.Cl,,C1COCCO1,,,,val
US20130131050A1,CCCSc1nc2[nH]c(=O)ccc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1.COCC(F)(F)CO>>COCC(F)(F)COc1nc2[nH]c(=O)ccc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1,,C1CCOC1,,O,[H-].[Na+],val
US06225318B1,C#Cc1cccc(Nc2ncnc3ccc(I)cc23)c1.C#Cc1ccccn1>>C#Cc1cccc(Nc2ncnc3ccc(C#Cc4ccccn4)cc23)c1,,CN(C)C=O,,CCNCC,,val
US20150353553A1,C[C@@H]1CC[C@@H](Cn2c(Br)nc3nc(Cl)nc(-c4cccc(Cl)c4)c32)CC1.C[C@H]1COCCN1>>C[C@H]1COCCN1c1nc2nc(Cl)nc(-c3cccc(Cl)c3)c2n1C[C@@H]1CC[C@@H](C)CC1,,CS(C)=O,O,[F-].[K+],,val
US20030158245A1,CCOC(=O)C1SC(S(C)(=O)=O)=C2C1=CC(C)(C)c1cnn(C)c12.Oc1ccc2c(c1)OCO2>>CCOC(=O)c1sc(Oc2ccc3c(c2)OCO3)c2c1CC(C)(C)c1cnn(C)c1-2,,CN1CCCC1=O,,O,CC(C)(C)[O-].[K+],val
US06297258B1,CN1CCC=C(CCl)C1.N#Cc1cnc2ccc(N)cc2c1Nc1cccc(Br)c1.O=C([O-])O>>CN1CCC=C(C(=O)Nc2ccc3ncc(C#N)c(Nc4cccc(Br)c4)c3c2)C1,,C1CCOC1,,Cl,,val
US04816452,O=C(OC(c1ccccc1)c1ccccc1)/C(=N\OC1(C(=O)OCc2ccc([N+](=O)[O-])cc2)CCCCC1)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>Nc1nc(/C(=N/OC2(C(=O)OCc3ccc([N+](=O)[O-])cc3)CCCCC2)C(=O)O)cs1,,O=CO,,,,val
US20060100262A1,COC(=O)Cn1c(Br)c(C2CCCCC2)c2ccc(C(=O)OC(C)(C)C)cc21>>CC(C)(C)OC(=O)c1ccc2c(C3CCCCC3)c(Br)n(CC(=O)O)c2c1,,O,,Cl,,val
US20120108595A1,CC(=O)c1cc(C(F)(F)F)cc(S(=O)(=O)N[C@H]2CCC[C@@H](n3cnnc3)C2)c1.COC(OC)N(C)C>>CN(C)/C=C/C(=O)c1cc(C(F)(F)F)cc(S(=O)(=O)N[C@H]2CCC[C@@H](n3cnnc3)C2)c1,,CCO,,,,val
US20090137561A1,COC(=O)CCc1cccc(OCc2ccc(-c3cccc(OC)c3)c(C)c2)c1>>COc1cccc(-c2ccc(COc3cccc(CCC(=O)O)c3)cc2C)c1,,C1CCOC1,CO,[Li+].[OH-],,val
US20100137281A1,CCc1cc(C(=O)OC)c(N)s1.Nc1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCc1cc2c(=O)n(-c3ccccc3)c(=O)[nH]c2s1,,ClCCl,,CCN(CC)CC,,val
US05202054,CCCCCC[C@@H](O)C(F)(F)F.O=C(Cl)c1ccc(OCc2ccccc2)cc1>>CCCCCCC(OC(=O)c1ccc(OCc2ccccc2)cc1)C(F)(F)F,,ClCCl,,CCN(CC)CC,CN(C)c1ccccn1,val
US20140271489A1,C=C(C)C(=O)Cl.COc1cc(OC)c(C2OCC(C)(CO)CO2)c(OC)c1>>C=C(C)C(=O)OCC1(C)COC(c2c(OC)cc(OC)cc2OC)OC1,,ClCCl,,CCN(CC)CC,CO,val
US20020115863A1,CCCCC(C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C)C1OC(OC)(c2ccccc2)OC1=O.NO>>CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C)[C@H](O)C(=O)NO,,C1COCCO1,,,,val
US04153716,O=Cc1cccc2c(-c3ccccc3)c([N+](=O)[O-])oc12>>O=[N+]([O-])c1oc2c(CO)cccc2c1-c1ccccc1,,COCCOC,O,Cl,[Na+].[OH-],val
US20100113462A1,CCOC(=O)C1(N)[C@@H](C)c2ccccc2[C@H]1C.O=C(O)c1cccc2c1CCCC2>>CCOC(=O)C1(NC(=O)c2cccc3c2CCCC3)[C@@H](C)c2ccccc2[C@H]1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20140018554A1,CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCC#N)cc1>>CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN)cc1,[Ni],CO,,,,val
US20040092737A1,COCN1c2cc(CN)ccc2Sc2nccnc21.O=C(Cl)CCl>>COCN1c2cc(CNC(=O)CCl)ccc2Sc2nccnc21,,CN(C)C=O,ClCCl,CCN(CC)CC,O,val
US20120115963A1,Cc1cc(C)c(C(=O)P(CCCBr)C(=O)c2c(C)cc(C)cc2C)c(C)c1.OO>>Cc1cc(C)c(C(=O)P(=O)(CCCBr)C(=O)c2c(C)cc(C)cc2C)c(C)c1,,Cc1ccccc1,,CCOCC,,val
US20090130117A1,COCCCN.O=C(O)c1cc(Br)c(OCc2ccccc2)cc1OCc1ccccc1>>COCCCNC(=O)c1cc(Br)c(OCc2ccccc2)cc1OCc1ccccc1,,CN(C)C=O,O,O=C(n1ccnc1)n1ccnc1,,val
US04833163,CCCCOC(=O)C=CC1C(C(=O)O)C1(C)C>>CC1(C)C(C=CC(=O)OCC2CC2)C1C(=O)O,,ClC(Cl)Cl,,,,val
US20120232056A1,COC(=O)c1ccc2nc(-c3ccc4[nH]ccc4c3)c(N3CCCC[C@@H]3C)nc2c1>>C[C@H]1CCCCN1c1nc2cc(C(=O)O)ccc2nc1-c1ccc2[nH]ccc2c1,,CO,ClC(Cl)Cl,O,[Na+].[OH-],val
US20140357615A1,COc1ccc(C=O)cc1.Cc1cc(C)c2c(n1)sc1c(N)n[nH]c12>>COc1ccc(CNc2n[nH]c3c2sc2nc(C)cc(C)c23)cc1,,ClCCCl,ClCCl,CC(=O)O,[Na+].[OH-],val
US20080234255A1,COCCN1CCC(=O)N(C)c2cnc(Cl)nc21.COc1cc(C(=O)O)ccc1N>>COCCN1CCC(=O)N(C)c2cnc(Nc3ccc(C(=O)O)cc3OC)nc21,Cl,O,,CCO,,val
US20120046268A1,COC(=O)C1CCN(C(=O)N2CC(NC(=O)c3ccccc3)CC(c3ccc(C(F)(F)F)cc3)C2)CC1>>O=C(NC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCC(C(=O)O)CC2)C1)c1ccccc1,,C1CCOC1,O,[Li+].[OH-],,val
US20080318946A1,COC(=O)c1c(Cl)ccc(C(=NO)Nc2cccc(C(F)(F)F)c2)c1F>>COC(=O)c1c(Cl)ccc2c(Nc3cccc(C(F)(F)F)c3)noc12,,CN(C)C=O,,[H-].[Na+],,val
US20090137804A1,Nc1ccc(OCCCN2CCOCC2)cc1.O=C(Nc1cc(Cl)ncn1)Nc1ccccc1Cl>>O=C(Nc1cc(Nc2ccc(OCCCN3CCOCC3)cc2)ncn1)Nc1ccccc1Cl,,CCO,O,Cl,,val
US20050038101A1,CC(C)(C)CC(=O)Cl.CCOC(=O)c1cc2cc(N)ccc2n1-c1ccccc1>>CCOC(=O)c1cc2cc(NC(=O)CC(C)(C)C)ccc2n1-c1ccccc1,,C1CCOC1,CCOC(C)=O,CCN(CC)CC,Cl,val
US20140107194A1,CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.CCCOC(=O)c1ccc(C[C@@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@H]2O)cc1>>CCCOC(=O)c1ccc(C[C@@]2(C3=Cc4ccccc4C3)Cc3ccccc3[C@H]2OC(=O)[C@@H](N)CC(C)C)cc1,CN(C)c1ccncc1,CCOC(C)=O,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20110319394A1,CCI.Cc1cnc2c(c1)[nH]c(=O)n2-c1ccc(OCc2ccccc2)cc1>>CCn1c(=O)n(-c2ccc(OCc3ccccc3)cc2)c2ncc(C)cc21,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20080108638A1,BrCCC1CCCCC1.CC(C)(C)OC(=O)Cn1c(S)nc2ccccc21>>CC(C)(C)OC(=O)Cn1c(SCCC2CCCCC2)nc2ccccc21,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080114005A1,NCCCO.O=c1[nH]c2ccccc2c(=O)o1>>Nc1ccccc1C(=O)NCCCO,,C1COCCO1,,,,val
US07279487B2,CN(CCn1c(=O)c(C(=O)NCc2ccc(F)cc2S(C)(=O)=O)c(O)c2ncccc21)C(=O)OCc1ccccc1>>CNCCn1c(=O)c(C(=O)NCc2ccc(F)cc2S(C)(=O)=O)c(O)c2ncccc21,,CO,,Cl,,val
US20030207896A1,O=Cc1ccc(OCCOc2cccc(Br)n2)cc1.OB(O)c1ccccc1-c1ccc(F)cc1F>>O=Cc1ccc(OCCOc2cccc(-c3ccc(F)cc3F)n2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20120202777A1,CCCCC(OC)ONC(=O)C(C)(CCc1ccc(C2=CCCCCC2)cc1)S(C)(=O)=O>>CC(CCc1ccc(C2=CCCCCC2)cc1)(C(=O)NO)S(C)(=O)=O,,ClCCl,,CO,Cl,val
US05344828,CCOC(=O)CBr.c1ccc2c(c1)Cc1ccccc1C(N1CCNCC1)=N2>>CCOC(=O)CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20120157436A1,CC(C)(C)OC(=O)NN.O=C(Cl)c1cccc(C(F)(F)F)c1Cl>>NNC(=O)c1cccc(C(F)(F)F)c1Cl,,C1COCCO1,ClCCl,CCN(C(C)C)C(C)C,Cl,val
US20100273764A1,COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(CN4CCN(S(C)(=O)=O)CC4)cnc3F)n2)cc1.Nc1ccc2ocnc2c1>>COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(-c3cc(CN4CCN(S(C)(=O)=O)CC4)cnc3Nc3ccc4ocnc4c3)n2)cc1,,C1CCOC1,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120115861A1,Nc1cc(NC(=O)COCCCl)ccc1[N+](=O)[O-]>>Nc1cc(N2CCOCC2=O)ccc1[N+](=O)[O-],,CC#N,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US04561876,CC1(N)COCOC1.O=C(Cl)C(Br)CBr>>CC1(NC(=O)C(Br)CBr)COCOC1,,ClCCl,,O,[Na+].[OH-],val
US05858995,Cc1ccc(O)cc1.O=C(Cl)c1c(Cl)cccc1Cl>>Cc1ccc(OC(=O)c2c(Cl)cccc2Cl)cc1,,ClCCl,,CCN(CC)CC,,val
US20100190980A1,N#Cc1nc(CCl)cnc1N.O=c1cccn[nH]1>>N#Cc1nc(Cn2ncccc2=O)cnc1N,,ClC(Cl)Cl,O,CN(C)C=O,[H-].[Na+],val
US20150148313A1,COC(=O)[C@H](C)O[Si](C)(C)C(C)(C)C>>C[C@@H](CO)O[Si](C)(C)C(C)(C)C,,C1CCOC1,,[BH4-].[Li+],,val
US20070219210A1,CCOC(=O)c1cc(-c2ccc(OCc3ccccc3)cn2)n(-c2cccnc2)n1>>CCOC(=O)c1cc(-c2ccc(O)cn2)n(-c2cccnc2)n1,[Pd],CCO,,CCOC(C)=O,[H][H],val
US20120245137A1,FC(F)(F)c1cccc(SC2CCC3(CC2)OCCO3)c1.O=C(OO)c1cccc(Cl)c1>>O=S(=O)(c1cccc(C(F)(F)F)c1)C1CCC2(CC1)OCCO2,,CO,ClCCl,O,O=C([O-])O.[Na+],val
US20110123449A1,CCOC(=O)c1c[nH]c2c(Cl)ccc(C(F)(F)F)c2c1=O>>O=C(O)c1c[nH]c2c(Cl)ccc(C(F)(F)F)c2c1=O,,O,,CC(=O)O,[Na+].[OH-],val
US20060252751A1,OC1(c2ccc(I)cc2)CCC2(CC1)OCCO2>>O=C1CCC(O)(c2ccc(I)cc2)CC1,,CC(C)=O,,Cl,[Na+].[OH-],val
US20080021069A1,CCOc1ccc(-n2c(NCc3ccc(Cl)cc3)nc3ccc(Cl)cc32)cc1.Cl>>CCOc1ccc(-n2c(NCc3ccc(Cl)cc3)nc3ccc(Cl)cc32)cc1.Cl,,CCOC(C)=O,,,,val
US20140323464A1,COc1cc(Nc2nc(NCc3ccc(N)cc3)n3ccnc3c2C(N)=O)cc(OC)c1.N#CCC(=O)O>>COc1cc(Nc2nc(NCc3ccc(NC(=O)CC#N)cc3)n3ccnc3c2C(N)=O)cc(OC)c1,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100010053A1,CCOC(=O)[C@@H]1C[C@H]1c1cn(C)c2c(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)cccc12>>CC(C)Oc1ccc(-c2nc(-c3cccc4c([C@@H]5C[C@H]5C(=O)O)cn(C)c34)no2)cc1Cl,,C1CCOC1,,Cl,[Na+].[OH-],val
US20090118287A1,CC1(C)CCC(=O)OC1.CO>>COC(=O)CCC(C)(C)CO,,CO,,C[O-].[Na+],,val
US20080108638A1,CCOC(=O)n1c2ccccc2c(=O)n1CCCSc1nc2ccccc2n1CC(=O)OC(C)(C)C>>CCOC(=O)n1c2ccccc2c(=O)n1CCCSc1nc2ccccc2n1CC(=O)O,,ClCCl,O=C(O)C(F)(F)F,,,val
US20040053908A1,CC1(C)OC(=O)CC(=O)O1.CCOC(OCC)OCC.COC(=O)c1ccc(N)cc1O>>COC(=O)c1ccc(NC=C2C(=O)OC(C)(C)OC2=O)cc1O,,CC(C)O,,,,val
US04797483,CC(C)OC(=O)CCl.O=C1NS(=O)(=O)c2ccccc21>>CC(C)OC(=O)CN1C(=O)c2ccccc2S1(=O)=O,,CN(C)C=O,O,[Na],,val
US04931436,CCN(CC)CCOCCC1CCCCN1.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>CCN(CC)CCOCCC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21,,CC#N,,,,val
US20040224974A1,CCc1nn2ccccc2c1N(CC1CC1)C(=O)C1CCOCC1>>CCc1nn2ccccc2c1N(CC1CCOCC1)CC1CC1,,C1CCOC1,,Cl,O,val
US07462617B2,CS(=O)(=O)c1ccc(I)c(C(=O)O)c1.FC(F)(F)c1ccc(N2CCNCC2)cc1>>CS(=O)(=O)c1ccc(I)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20130178540A1,CCCCCCCCCCCCCCO.CCOC(C)=O.CSCCC(O)C(=O)O.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1>>CCCCCCCCCCCCCCOC(=O)C(CCSC)OC(=O)C(O)CCSC,,CCOC(C)=O,,O,,val
US20140179672A1,CC(=O)Cc1nc2ccccc2s1.N.[C-]#N>>CC(N)(C#N)Cc1nc2ccccc2s1,,CO,ClCCl,[Cl-].[NH4+],,val
US20090264416A1,COC(=O)c1ccc(OC)c(CCl)c1.O=C(Nc1ccccc1)Nc1ccc(C(=O)N2CCNCC2)cc1>>COC(=O)c1ccc(OC)c(CN2CCN(C(=O)c3ccc(NC(=O)Nc4ccccc4)cc3)CC2)c1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20100029619A1,CC(=O)Nc1cn2nc(I)ccc2n1.Nc1cccc(O)c1>>CC(=O)Nc1cn2nc(Oc3cccc(N)c3)ccc2n1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20090197959A1,CCN.CS(=O)(=O)c1ccc(O)c(C=O)c1>>CCNCc1cc(S(C)(=O)=O)ccc1O,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US05707989,CNC.Cc1cccc(Nc2ncnc3cnc(N4CCC(C(=O)O)CC4)nc23)c1>>Cc1cccc(Nc2ncnc3cnc(N4CCC(C(=O)N(C)C)CC4)nc23)c1,,CCN(CC)CC,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,,val
US06252084B1,CCc1c(C(=O)C(N)=O)c2c(OC)cccc2n1Cc1ccccc1>>CCc1c(C(O)C(N)=O)c2c(OC)cccc2n1Cc1ccccc1,,CCO,,[BH4-].[Na+],,val
US20130102776A1,COc1ccc2c(c1CCCCN1CCN(C(=O)OC(C)(C)C)CC1)OCC2=O.O=Cc1n[nH]c2ccccc12>>COc1ccc2c(c1CCCCN1CCN(C(=O)OC(C)(C)C)CC1)O/C(=C\c1n[nH]c3ccccc13)C2=O,C1CCNCC1,CO,,,,val
US20080064719A1,COc1cc(Br)ccc1C(=O)CBr.O=C1NC(=O)c2ccccc21>>COc1cc(Br)ccc1C(=O)CN1C(=O)c2ccccc2C1=O,,CN(C)C=O,,[K],,val
US20080234255A1,CCOC(=O)CC(C)N(c1nc(Cl)ncc1[N+](=O)[O-])C1CCCC1>>CC1CC(=O)Nc2cnc(Cl)nc2N1C1CCCC1,[Fe],CC(=O)O,,,,val
US20020022729A1,CC(C)(C)OC(=O)NOC(=O)OC(C)(C)C.Cc1c(-c2ccncc2)sc(-c2ccncc2)c1CO>>Cc1c(-c2ccncc2)sc(-c2ccncc2)c1CN(OC(=O)OC(C)(C)C)C(=O)OC(C)(C)C,,C1CCOC1,O,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20080194562A1,Cc1cccc(Cl)c1C(=O)O.ClCCl>>COC(=O)c1c(C)cccc1Cl,,ClCCl,,CN(C)C=O,O=C(Cl)C(=O)Cl,val
US03960861,COc1cc2nc(N3CCc4ccc([N+](=O)[O-])cc4C3)nc(N)c2cc1OC>>COc1cc2nc(N3CCc4ccc(N)cc4C3)nc(N)c2cc1OC,,Cl,,,,val
US20120115846A1,COc1ccc(CN)cc1OC.O=C(O)c1cc(OCc2ccccc2)c(F)cc1NC1CCOCC1>>COc1ccc(CNC(=O)c2cc(OCc3ccccc3)c(F)cc2NC2CCOCC2)cc1OC,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060264631A1,CC(C)(C)OC(=O)N1CCN(c2cccc3oc(-c4ccc(C(C)(C)C)cc4)nc23)CC1>>CC(C)(C)c1ccc(-c2nc3c(N4CCNCC4)cccc3o2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060135578A1,COc1cc(COc2nn(C)cc2C=O)ccc1OCc1nc(-c2ccccc2)oc1C.C[Mg]Br>>COc1cc(COc2nn(C)cc2C(C)O)ccc1OCc1nc(-c2ccccc2)oc1C,,C1CCOC1,,Cl,,val
US20150218124A1,COc1cc(C#N)c(Cc2ccc(C(=O)O)cc2)c(C#N)c1O>>N#Cc1cc(O)c(O)c(C#N)c1Cc1ccc(C(=O)O)cc1,,ClCCl,,BrB(Br)Br,,val
US20120053180A1,CC(C)CC(=O)Cl.CS(=O)(=O)c1ccc(-c2cc(F)c(OC3CCC(N)CC3)c(F)c2)cc1>>CC(C)CC(=O)NC1CCC(Oc2c(F)cc(-c3ccc(S(C)(=O)=O)cc3)cc2F)CC1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110269744A1,COC(=O)CBr.Cc1c(O)c([N+](=O)[O-])cc2c1CCN(C(=O)OC(C)(C)C)CC2>>COC(=O)COc1c([N+](=O)[O-])cc2c(c1C)CCN(C(=O)OC(C)(C)C)CC2,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20020072533A1,II.O=C1CC(CO)CN1Cc1ccccc1>>O=C1CC(CI)CN1Cc1ccccc1,,Cc1ccccc1,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100273739A1,C#CCNS(=O)(=O)CCC.CCOC(=O)NC1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1Cc1ccc(Cl)c(Cl)c1>>CCCS(=O)(=O)NCC#Cc1ccc2c(c1)C(Cc1ccccc1)C(NC(C)=O)CC2,[Cu]I,C1COCCO1,,CCN(CC)CC,O,val
US20130023541A1,CCNCc1ccc(CN2CCN(c3ncccc3C(=O)OC(C)C)CC2)cc1.Cc1cccc(C=O)n1>>CCN(Cc1ccc(CN2CCN(c3ncccc3C(=O)OC(C)C)CC2)cc1)Cc1cccc(C)n1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US05843967,Nc1ccc2ncccc2c1.O=C(Cl)OCc1ccccc1>>O=C(Nc1ccc2ncccc2c1)OCc1ccccc1,,C1CCOC1,O,[Na+].[OH-],,val
US20150197509A1,CC(C)(C)OC(=O)NCc1cccc(-c2cnc(C(F)(F)F)cn2)c1>>NCc1cccc(-c2cnc(C(F)(F)F)cn2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20110172230A1,CC(C)(C)OC(=O)N1CCN(C(=O)c2cccc(OCCCc3ccccc3)c2)CC1.Cl>>Cl.O=C(c1cccc(OCCCc2ccccc2)c1)N1CCNCC1,,CCOC(C)=O,,,,val
US07709479B1,COc1cc2c(SC)ncnc2cc1OCC#N.NCCN>>COc1cc2c(SC)ncnc2cc1OCC1=NCCN1,,CCO,ClCCl,Cl,,val
US20140221343A1,COc1ccc(Cn2c(Sc3cc4c(cc3C)OCO4)nc3c(N)nccc32)cc1>>Cc1cc2c(cc1Sc1nc3c(N)nccc3[nH]1)OCO2,,O=C(O)C(F)(F)F,,,,val
US20030018064A1,CCOC(=O)CCc1coc2cc(OCCc3cccc(NC)n3)ccc12>>CNc1cccc(CCOc2ccc3c(CCC(=O)O)coc3c2)n1,,C1CCOC1,,[Na+].[OH-],,val
US20150166480A1,CCOC(=O)c1ccc(-c2cnc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cn2)cc1F>>O=C(O)c1ccc(-c2cnc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cn2)cc1F,,C1CCOC1,,O,[Li]O,val
US20160168156A1,CC(C)C(=O)NNC(=O)c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)c1nnc(-c2cnn3ccc(N4CCCC4c4cc(F)ccc4F)nc23)s1,,Cc1ccccc1,,,,val
US20080009482A1,C=CC(=O)NCC.NC1CCCC1>>CCNC(=O)CCNC1CCCC1,,CO,,,,val
US20120184553A1,O=C(OCc1ccc(F)c(F)c1)c1cc(Br)ccc1OCc1ccc(F)c(F)c1>>O=C(O)c1cc(Br)ccc1OCc1ccc(F)c(F)c1,,C1CCOC1,O,[Li+].[OH-],,val
US20150291573A1,FC(F)(F)c1cccc(S)c1.O=S(=O)([O-])CC1CCOC(c2ccc(C(F)(F)F)cc2Br)C1>>FC(F)(F)c1cccc(SC2CCOC(c3ccc(C(F)(F)F)cc3Br)C2)c1,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US04208327,O=C(O)CNC(=O)OCC(Cl)(Cl)Cl.O=S(Cl)Cl>>O=C(Cl)CNC(=O)OCC(Cl)(Cl)Cl,,Cc1ccccc1,,,,val
US20120046269A1,NC(=O)c1cccc2c(NCc3ccc(N)cc3)ncnc12.O=C=Nc1ccccc1>>NC(=O)c1cccc2c(NCc3ccc(NC(=O)Nc4ccccc4)cc3)ncnc12,,ClCCl,,CCN(CC)CC,,val
US20150038528A1,COC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O.NCC[C@H](O)C(=O)O>>N#Cc1nc(C(=O)NCC[C@H](O)C(=O)O)c(O)c2ccc(Oc3ccccc3)cc12,,COCCO,,C[O-].[Na+],,val
US05986029,CCCCNCCCC.CCOC(=O)CCBr>>CCCCN(CCCC)CCC(=O)OCC,,CCCCC,,CCOCC,,val
US20150291563A1,CN(CCCS(=O)(=O)c1cccc(-c2ccc(C3CC(C(O)(C(F)(F)F)C(F)(F)F)=NN3c3ccc(F)cc3F)cc2)c1)C(=O)OC(C)(C)C>>CNCCCS(=O)(=O)c1cccc(-c2ccc(C3CC(C(O)(C(F)(F)F)C(F)(F)F)=NN3c3ccc(F)cc3F)cc2)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20040157804A1,CC(C)(C)OC(=O)N1CCN(Cc2ccc(F)cc2)C(=O)C1.O=C(O)C(F)(F)F>>O=C([O-])C(F)(F)F.O=C1C[NH2+]CCN1Cc1ccc(F)cc1,,ClCCl,,,,val
US04490369,COc1cc2c(cc1Br)CCNC(=O)C2.ClCCCBr>>COc1cc2c(cc1Br)CCN(CCCCl)C(=O)C2,,CS(C)=O,,[H-].[Na+],,val
US20070060754A1,CC(=O)OC(C)=O.CCOCc1nc2c(N)nc3cc(ON4CCCCC4)ccc3c2n1CC(C)(C)O>>CCOCc1nc2c(N)nc3cc(OC4CCCCN4C(C)=O)ccc3c2n1CC(C)(C)O,,ClCCl,,,,val
US20100173888A1,Cn1nnnc1Cl.O=C(N[C@@H]1CC[C@@H](O)CC1)c1ccc(-c2cccc(F)c2)nc1>>Cn1nnnc1O[C@@H]1CC[C@@H](NC(=O)c2ccc(-c3cccc(F)c3)nc2)CC1,,C1CCOC1,,[H-].[Na+],,val
US20060241097A1,CI.c1cncc(-c2cnsn2)c1>>CN1CCC=C(c2cnsn2)C1,,CC(C)=O,,,,val
US20110207147A1,COc1ccc2c3c(n(C)c2c1)-c1cc(F)ccc1C3.C[Si](C)(C)Cl>>COc1ccc2c3c(n(C)c2c1)-c1cc(F)ccc1C3[Si](C)(C)C,,CCOCC,,[Li]CCCC,,val
US20120295915A1,Nc1cccnc1NC[C@@H]1CCN(C(=O)C2CC2)C1.O=Cc1ccc(-c2ccc3cc[nH]c3c2)cc1>>O=C(C1CC1)N1CC[C@@H](Cn2c(-c3ccc(-c4ccc5cc[nH]c5c4)cc3)nc3cccnc32)C1,,CN1CCCC1=O,,,,val
US20020028836A1,CC(C)(C=O)C1CCCCC1.NC(=O)c1ccc(Cl)cc1.c1ccc2[nH]nnc2c1>>CC(C)(C1CCCCC1)C(NC(=O)c1ccc(Cl)cc1)n1nnc2ccccc21,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20100010060A1,CC(C)(C)[Si](C)(C)Cl.O=C(Nc1cccc2c1C(=O)N(Cc1ccc(NCCO)cc1)C2)c1ccc(Cl)s1>>CC(C)(C)[Si](C)(C)OCCNc1ccc(CN2Cc3cccc(NC(=O)c4ccc(Cl)s4)c3C2=O)cc1,,CN(C)C=O,,c1c[nH]cn1,,val
US20100197760A1,OC1(c2cc(F)cc(F)c2)CCN(Cc2ccccc2)C1>>Fc1cc(F)cc(C2=CCN(Cc3ccccc3)C2)c1,,ClCCl,,O,[Na+].[OH-],val
US20080009512A1,COC(=O)C(=Cc1ccncc1[N+](=O)[O-])NC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)NC1Cc2ccncc2NC1=O,[Pd],CCO,,[H][H],,val
US20070112023A1,CC(C)NS(=O)(=O)c1ccc(-c2ccc(N)cc2)cc1.Cl.O=C(Cl)[C@H]1CN2CCC1CC2>>CC(C)NS(=O)(=O)c1ccc(-c2ccc(NC(=O)[C@H]3CN4CCC3CC4)cc2)cc1.Cl,,CN(C)C=O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20140336190A1,CCN(CC)S(F)(F)F.Cc1noc(C)c1-c1cc(C(O)(c2ccccn2)c2ccccn2)c2nc(C3CC3)[nH]c2c1F>>Cc1noc(C)c1-c1cc(C(F)(c2ccccn2)c2ccccn2)c2nc(C3CC3)[nH]c2c1F,,ClCCl,,O=C([O-])O.[Na+],,val
US20110046127A1,CCOC(=O)c1cccc(NC(=O)c2cnc3c(C)cc(NCc4ccc(OC)cc4)nn23)c1.CN>>CNC(=O)c1cccc(NC(=O)c2cnc3c(C)cc(NCc4ccc(OC)cc4)nn23)c1,,ClCCl,,C[Al](C)C,,val
US20020156313A1,CC(C)=O.FC(F)(F)c1cc(Br)cc(C(F)(F)F)c1>>CC(C)(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,,CCOCC,,[Mg],[Cl-].[NH4+],val
US20080300216A1,Cl[Si](c1ccccc1)(c1ccccc1)c1ccccc1.O=c1ccn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]1>>O=c1ccn([C@H]2C[C@H](O)[C@@H](CO[Si](c3ccccc3)(c3ccccc3)c3ccccc3)O2)c(=O)[nH]1,,ClC(Cl)Cl,c1ccncc1,CO,,val
US20090286811A1,COc1cccc(C=O)c1OCCC(C)C.Cc1nc2sccn2c(=O)c1-c1ccc(C(F)(F)F)cc1>>COc1cccc(/C=C/c2nc3sccn3c(=O)c2-c2ccc(C(F)(F)F)cc2)c1OCCC(C)C,,CCO,,C,C[O-].[Na+],val
US20160136076A1,NCCCCCO.O=C(Cl)c1cccnc1>>O=C(NCCCCCO)c1cccnc1,,O,,ClCCl,,val
US05177095,C=CCc1cc(CO)ccc1O>>CCCc1cc(CO)ccc1O,[Rh],CCO,,[H][H],,val
US05691335,COc1cccc(C(=O)Cl)c1.O=C1CN(c2ccccc2)C(=O)N1>>COc1cccc(C(=O)N2C(=O)CN(c3ccccc3)C2=O)c1,,c1ccncc1,,,,val
US20100152183A1,CC(c1ccccc1-c1ccc(Cl)cc1)N1CCN(C(=O)OC(C)(C)C)CC1>>CC(c1ccccc1-c1ccc(Cl)cc1)N1CCNCC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20120046278A1,CO.CS(=O)(=O)c1nc(N)nc2sc(C3CC3)nc12>>COc1nc(N)nc2sc(C3CC3)nc12,,C1COCCO1,CO,O=C([O-])[O-].[K+].[K+],,val
US20140018343A1,CCOC(=O)Cc1ccc2sc3ncnc(Cl)c3c2c1>>OCCc1ccc2sc3ncnc(Cl)c3c2c1,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20160272617A1,Cc1cc(C(=O)N[C@H]2CCCN(C)C2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1.Cl>>Cc1cc(C(=O)N[C@H]2CCCN(C)C2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CN)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1.Cl,,C1COCCO1,,O=C(O)C(F)(F)F,,val
US05977111,O=S1(=O)c2ccccc2C(O)CC1CCCN1CCN(c2ccc(F)cc2)CC1>>O=S1(=O)c2ccccc2C=CC1CCCN1CCN(c2ccc(F)cc2)CC1,,Cl,,[Na+].[OH-],,val
US04286090,COc1ccc(-c2nnn[nH]2)c(N)c1.O=N[O-]>>COc1ccc2c(c1)nnn1nnnc21,,ClC(Cl)Cl,,Cl,,val
US20110201593A1,CC(C)(C)OC(=O)N1CCC(N)CC1.O=[N+]([O-])c1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1Cl>>CC(C)(C)OC(=O)N1CCC(Nc2c([N+](=O)[O-])cnc3c2ccn3S(=O)(=O)c2ccccc2)CC1,,CC(C)O,,CCN(C(C)C)C(C)C,,val
US20120283242A1,CCOC(=O)c1ccc2cc(Oc3ccc([N+](=O)[O-])cn3)ccc2c1>>CCOC(=O)c1ccc2cc(Oc3ccc(N)cn3)ccc2c1,[Pd],CCO,,,,val
US20100173888A1,N.O=C(N[C@H]1CC[C@@H](C(=O)O)C1)c1ccc(-c2cccc(F)c2)nc1>>NC(=O)[C@@H]1CC[C@H](NC(=O)c2ccc(-c3cccc(F)c3)nc2)C1,,C1COCCO1,CN(C)C=O,O=C(n1ccnc1)n1ccnc1,,val
US20020072604A1,CC(C)(C)OC(=O)N1Cc2ccccc2C[C@@H]1C(=O)O.O=C1CCC(=O)N1O>>CC(C)(C)OC(=O)N1Cc2ccccc2C[C@@H]1C(=O)ON1C(=O)CCC1=O,,ClCCl,O,CCN(CC)CC,ClCCCl,val
US04052383,N=C(c1ccccc1)C1CCN1C(c1ccccc1)c1ccccc1.O=S(=O)(O)O>>O=C(c1ccccc1)C1CCN1C(c1ccccc1)c1ccccc1,,CO,,O=C([O-])O.[Na+],,val
US04430339,C=C(CCCCCCCC1CCCCC1)C(=O)OCC.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)C1(CCCCCCCC2CCCCC2)CO1,,ClCCl,,,,val
US20050020623A1,CC(C)(C)OC(=O)NCc1ccc(CNS(=O)(=O)c2cccc3cnccc23)cc1>>NCc1ccc(CNS(=O)(=O)c2cccc3cnccc23)cc1,,CO,,Cl,,val
US20150166594A1,COc1ccc(CO[C@H]2C(=O)[C@@H](CO[Si](C)(C)C(C)(C)C)O[C@@H](OCC[Si](C)(C)C)[C@@H]2OCc2ccccc2)cc1.[Li]C>>COc1ccc(CO[C@@H]2[C@@H](OCc3ccccc3)[C@H](OCC[Si](C)(C)C)O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]2(C)O)cc1,,CCOCC,,,,val
US20100286118A1,CC(C)(C)OC(=O)NC1(C(=O)N[C@@H](Cc2ccc(I)cc2)C(N)=O)CCOCC1.OB(O)c1ccc(F)c(F)c1>>CC(C)(C)OC(=O)NC1(C(=O)N[C@@H](Cc2ccc(-c3ccc(F)c(F)c3)cc2)C(N)=O)CCOCC1,,CC#N,,O=C([O-])[O-].[Na+].[Na+],,val
US20150291713A1,CC(C)(C)CC(C)(C)c1ccc(OC2CCCCO2)c(-n2c3cc(C(C)(C)C)ccc3c3ccc(C(C)(C)C)cc32)c1.CC(C)OB1OC(C)(C)C(C)(C)O1>>CC(C)(C)CC(C)(C)c1cc(B2OC(C)(C)C(C)(C)O2)c(OC2CCCCO2)c(-n2c3cc(C(C)(C)C)ccc3c3ccc(C(C)(C)C)cc32)c1,,C1CCOC1,CC#N,[Li]CCCC,O=C([O-])O.[Na+],val
US20140031392A1,COC(=O)c1ccccc1N=C=O.FC(F)(F)c1ccccc1C1CCNCC1>>O=C(O)c1ccccc1NC(=O)N1CCC(c2ccccc2C(F)(F)F)CC1,,C1CCOC1,,CCN(CC)CC,Cl,val
US20110288065A1,CC(=O)OC(C)=O.C[C@H](Nc1cc(N)cc(Nc2cnccn2)n1)c1ccc(F)cc1>>CC(=O)Nc1cc(Nc2cnccn2)nc(N[C@@H](C)c2ccc(F)cc2)c1,CN(C)c1ccncc1,ClCCl,O,CCN(CC)CC,,val
US20040192728A1,Brc1ccc2c(c1)CCN2.O=C1CCCCC1>>Brc1ccc2c(c1)CCN2C1CCCCC1,,CO,,[BH3-]C#N.[Na+],,val
US20080207654A1,CCCc1nc(CC)n(-c2ccc(C(C)=O)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.[Li]C>>CCCc1nc(CC)n(-c2ccc(C(C)(C)O)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1,,C1CCOC1,,[Cl-].[NH4+],,val
US20070191340A1,BrCc1ccc(Br)cc1.c1ccc(C2CCNC2)cc1>>Brc1ccc(CN2CCC(c3ccccc3)C2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100204196A1,C=CS(C)(=O)=O.COc1cc(N2CCNCC2)c(C)cc1[N+](=O)[O-]>>COc1cc(N2CCN(CCS(C)(=O)=O)CC2)c(C)cc1[N+](=O)[O-],,C1COCCO1,,,,val
US20100137305A1,CC(C)(C)OC(=O)N1CC[C@@H](N)C1.CC(C)=O>>CC(C)=N[C@@H]1CCN(C(=O)OC(C)(C)C)C1,,ClCCl,,O=S(=O)([O-])[O-].[Mg+2],,val
US20150232501A1,C[C@H](N)C(=O)OC1CCCCC1.Cl.O=P(Cl)(Cl)Oc1ccccc1.Oc1c(F)c(F)c(F)c(F)c1F>>C[C@H](NP(=O)(Oc1ccc(Cl)cc1)Oc1c(F)c(F)c(F)c(F)c1F)C(=O)OC1CCCCC1,,ClCCl,,CCN(CC)CC,,val
US20140131664A1,Brc1ccc(-c2ccc3ccc4cccc5ccc2c3c45)cc1.CC1(C)C=CC=C2C=c3cc4c5cc(B6OC(C)(C)C(C)(C)O6)ccc5c5ccccc5c4cc3=C21>>CC1(C)C=C(c2ccc(-c3ccc4ccc5cccc6ccc3c4c56)cc2)C=C2C=c3cc4c5ccccc5c5ccccc5c4cc3=C21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,CCO,O=C([O-])[O-].[Na+].[Na+],val
US05434202,C#CC(=O)OCC.CCCCCCCCN(C=O)C1CC(C)(C)NC(C)(C)C1>>CCCCCCCCN(C=O)C1CC(C)(C)N(C=CC(=O)OCC)C(C)(C)C1,,Cc1ccccc1,,,,val
US20040102635A1,CCOC(OCC)OCC.O=C(CC(=O)C1CC1)c1ccc(Cl)c(Cn2nnn(C3CC3)c2=O)c1Cl>>CCOC=C(C(=O)c1ccc(Cl)c(Cn2nnn(C3CC3)c2=O)c1Cl)C(=O)C1CC1,,CC(=O)OC(C)=O,,,,val
US20100069431A1,COC(=O)CNCc1cnc2[nH]c(-c3cc(OCc4ccccc4)ccc3OC(C)C)nc2c1>>CC(C)Oc1ccc(OCc2ccccc2)cc1-c1nc2cc(CNCC(=O)O)cnc2[nH]1,,CO,,O=C(O)CC(O)(CC(=O)O)C(=O)O,[Na+].[OH-],val
US20060228313A1,O=C1COc2cccc(O)c21.O=Cc1ccc(O)cc1>>O=C1/C(=C/c2ccc(O)cc2)Oc2cccc(O)c21,,CO,,O,[K+].[OH-],val
US05173493,Cc1c(C=C2CCc3cc4ccccc4n3C2=O)ncn1C(c1ccccc1)(c1ccccc1)c1ccccc1>>Cc1[nH]cnc1C=C1CCc2cc3ccccc3n2C1=O,,O,,CC(=O)O,,val
US20080194535A1,C=CCCCBr.COc1ccc(Br)c(C(OC)OC)c1>>C=CCCCc1ccc(OC)cc1C=O,,C1CCOC1,,Cl,[Li]CCCC,val
US04971994,CC(=O)Cl.CC(C)NC(=S)Nc1c(C(C)C)cc(Oc2ccccc2F)cc1C(C)C>>CC(=O)SC(=NC(C)C)Nc1c(C(C)C)cc(Oc2ccccc2F)cc1C(C)C.Cl,,CC(C)=O,,,,val
US20130274272A1,CC(C)(O)C(=N)N.COC(OC)N(C)C.COc1ccc(COc2cc(C)n(-c3cc(C(C)=O)ncc3C)c(=O)c2Cl)cc1>>COc1ccc(COc2cc(C)n(-c3cc(-c4ccnc(C(C)(C)O)n4)ncc3C)c(=O)c2Cl)cc1,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20140315888A1,CNC1CN(c2nc3ncc(Br)cc3n3cnnc23)C1.OB(O)c1ccco1>>CNC1CN(c2nc3ncc(-c4ccco4)cc3n3cnnc23)C1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070173506A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc2cc(Br)ccc2cn1>>CC(C)(C)OC(=O)Nc1cc2cc(Br)ccc2cn1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US06207693B1,Cc1ccc(S(=O)(=O)Cl)cc1.O=C(OCc1ccccc1)c1cccc2[nH]ccc12>>Cc1ccc(S(=O)(=O)n2ccc3c(C(=O)OCc4ccccc4)cccc32)cc1,,C1CCOC1,,[H-].[Na+],,val
US20140113882A1,CON(C)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)OC(C)(C)C.Cl[Mg]c1ccccc1>>CC(C)(C)OC(=O)N1CCN(C(=O)OC(C)(C)C)[C@@H](C(=O)c2ccccc2)C1,,C1CCOC1,,,,val
US04312870,CN=C=O.Nc1ccc(-n2nc3c4ccccc4[nH]cc-3c2=O)cc1>>CNC(=O)Nc1ccc(-n2nc3c4ccccc4[nH]cc-3c2=O)cc1,,CO,,,,val
US05929082,O=[N+]([O-])O.[O-][n+]1ccccc1Br>>O=[N+]([O-])c1cc[n+]([O-])c(Br)c1,,O=S(=O)(O)O,,,,val
US20060025417A1,CC(C)(C)OC(=O)N1CC2C[C@H]1CN2.Cn1c(Cl)nc(-c2ccncn2)cc1=O>>Cn1c(N2C[C@@H]3CC2CN3C(=O)OC(C)(C)C)nc(-c2ccncn2)cc1=O,,C1CCOC1,,CCN(CC)CC,O,val
US05330986,O=C(O)c1cccc2cc[nH]c12.c1ccc(N2CCNCC2)cc1>>O=C(c1cccc2cc[nH]c12)N1CCN(c2ccccc2)CC1,,CN(C)C=O,,,,val
US20120035140A1,O=C(N[C@H](CO)CNS(=O)(=O)c1ccc(Oc2ccccc2)cc1)OCc1ccccc1.[N-]=[N+]=N>>[N-]=[N+]=NC[C@H](CNS(=O)(=O)c1ccc(Oc2ccccc2)cc1)NC(=O)OCc1ccccc1,,Cc1ccccc1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110319394A1,CC(C)n1c(=O)n(-c2ccc(O)cc2)c2ncc(Cl)cc21.Cn1c(S(C)(=O)=O)nc2cccnc21>>CC(C)n1c(=O)n(-c2ccc(Oc3nc4cccnc4n3C)cc2)c2ncc(Cl)cc21,,CN(C)C=O,CO,[H-].[Na+],,val
US20090176786A1,CNc1ccc(SC(F)(F)F)c(C)c1C.O=C=NC(=O)c1c(F)cccc1F>>Cc1c(SC(F)(F)F)ccc(N(C)C(=O)NC(=O)c2c(F)cccc2F)c1C,,COC(C)(C)C,,CCCCCC,,val
US20130303492A1,COc1ccc(C=O)cc1.NC(=O)c1c(Nc2cccnc2)n[nH]c1N>>COc1ccc(C=Nc2[nH]nc(Nc3cccnc3)c2C(N)=O)cc1,,CCO,,C1CCNCC1,,val
US20160031899A1,CC(=O)OC[C@H]1C[C@@H](OC(C)=O)CC[C@]1(C)[C@H]1CC[C@]2(C)C(c3ccccc3)=CC[C@H]2[C@@H]1CNC(=O)C(F)(F)F.O=C(OO)c1cccc(Cl)c1>>CC(=O)OC[C@H]1C[C@@H](OC(C)=O)CC[C@]1(C)[C@H]1CC[C@@]2(C)[C@@H](C[C@H]3O[C@]32c2ccccc2)[C@@H]1CNC(=O)C(F)(F)F,,ClCCl,,,,val
US05112998,COCO[C@@H]1CC2=CC=C3[C@@H]4CC[C@H](C(C)C=O)[C@@]4(C)CC[C@@H]3[C@@]2(C)[C@@H](OC(C)=O)C1>>COCO[C@@H]1CC2=CC=C3[C@@H]4CC[C@H](C(C)C=O)[C@@]4(C)CC[C@@H]3[C@@]2(C)[C@@H](O)C1,,CO,,C[O-].[Na+],,val
US20160046596A1,C[Si](C)(C)C#N.Cc1nccc(C=Nc2ccc(F)c(Cl)c2)c1O>>Cc1nccc2c(Nc3ccc(F)c(Cl)c3)c(N)oc12,,ClCCl,,,,val
US20080242692A1,COc1ccc(C=NCC(OC)OC)cc1OC.COc1ccc(C=O)c(OC)c1OC>>COc1ccc(C=NCC(OC)OC)c(OC)c1OC,,c1ccccc1,,,,val
US20150065499A1,CN(C)C=O.COc1cc2c(cc1O)ncc1c(N)c(C(=O)[O-])sc12.ClCCN1CCOCC1>>COC(=O)c1sc2c(cnc3cc(OCCN4CCOCC4)c(OC)cc32)c1N,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20090281103A1,COCCCc1cc(CN(C(=O)C(CNC(=O)OC(C)(C)C)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)cc(O[Si](C)(C)C(C)(C)C)n1>>COCCCc1cc(CN(C(=O)C(CN)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)cc(O)n1,,ClCCl,,Cl,,val
US20090221825A1,COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314>>CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5,,ClC(Cl)Cl,,BrB(Br)Br,O,val
US20120028919A1,CN1CCN(CCOc2ccc([N+](=O)[O-])cc2)CC1>>CN1CCN(CCOc2ccc(N)cc2)CC1,[Pd],,,CCO,,val
US20020137931A1,COc1ccc(-c2ccc(C#N)c(C)c2)cc1>>Cc1cc(-c2ccc(O)cc2)ccc1C#N,,ClCCl,,BrB(Br)Br,O,val
US05455258,COc1ccc(S(=O)(=O)N(Cc2cccnc2)[C@@H](C(=O)NOCc2ccccc2)C(C)C)cc1>>COc1ccc(S(=O)(=O)N(Cc2cccnc2)[C@@H](C(=O)NO)C(C)C)cc1,[Pd],,,[H][H],,val
US20140094459A1,CC(C)(C)OC(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1>>Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCNC1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20150038438A1,CNc1c(C#C[Si](C)(C)C)cc2c(c1I)OCCCC2=O>>Cn1ccc2cc3c(c(I)c21)OCCCC3=O,[Cu]I,,,,,val
US20070032515A1,COC(=O)c1ccc(OC)c(OCC2CCN(C(=O)OC(C)(C)C)CC2)c1>>COc1ccc(CO)cc1OCC1CCN(C(=O)OC(C)(C)C)CC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130310362A1,Cc1nc(N)c(-c2ccccc2)c(-c2ccc(C=O)cc2)n1.O=CCCl>>Cc1nc(-c2ccc(C=O)cc2)c(-c2ccccc2)c2nccn12,,CCO,,,,val
US20150322002A1,CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(F)cc1F.OCc1ccc(Cl)c(Cl)c1>>CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCc2ccc(Cl)c(Cl)c2)cc1F,,CCOC(C)=O,CS(C)=O,CC(C)(C)[O-].[K+],,val
US20140296225A1,N#Cc1cc(CCN(CCNC(=O)[O-])C(=O)CCl)ccc1F>>N#Cc1cc(CCN2CCNCC2=O)ccc1F,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])[O-].[K+].[K+],val
US20050154042A1,COC(=O)C[C@H](O)C[C@H](O)C=Cc1c(-c2ccc(F)cc2)c(-c2ccc(F)cc2)c(C(=O)Nc2ccc(S(N)(=O)=O)cc2)n1C(C)C>>COC(=O)C[C@H](O)C[C@H](O)CCc1c(-c2ccc(F)cc2)c(-c2ccc(F)cc2)c(C(=O)Nc2ccc(S(N)(=O)=O)cc2)n1C(C)C,[Pd],C1CCOC1,CCO,,,val
US20110039852A1,CO.O=C(O)Cc1cc(Br)ccc1F>>COC(=O)Cc1cc(Br)ccc1F,,C1COCCO1,,Cl,,val
US05284847,CCOC(=O)C(=O)Nc1sc(C(C)C)cc1[N+](=O)[O-]>>CC(C)c1cc2[nH]c(=O)c(=O)[nH]c2s1,,C1COCCO1,O,O=S([O-])S(=O)[O-].[Na+].[Na+],,val
US20110065699A1,Clc1ccc(-c2cn3cc(Br)ccc3n2)cc1.O=Cc1cccc(B(O)O)c1F>>O=Cc1cccc(-c2ccc3nc(-c4ccc(Cl)cc4)cn3c2)c1F,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20020032189A1,CN(C)CC1CCc2cc(O)ccc2C1.Cl.ClCc1ccc2ccccc2n1>>CN(C)CC1CCc2cc(OCc3ccc4ccccc4n3)ccc2C1.Cl.Cl,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20100210617A1,Clc1ccccc1.O=C(Cl)c1ccc(Br)cc1F>>O=C(c1ccc(Cl)cc1)c1ccc(Br)cc1F,,Clc1ccccc1,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US20150111882A1,N=C(N)SCC=C1CCCc2sccc21>>NC1=NC2(CCCc3sccc32)CCS1,,Cl,,[Na+].[OH-],,val
US20150038574A1,CC1(C)C=C(C=O)C(C)(C)CC1>>CC1(C)C=C(CO)C(C)(C)CC1,,CO,,O,[BH4-].[Na+],val
US20050288314A1,O=C(O)C(O)c1ccc2c(c1)OCO2>>OCC(O)c1ccc2c(c1)OCO2,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030229094A1,C1CNCCN1.Cc1cccnc1Br>>Cc1cccnc1N1CCNCC1,,CCCCO,,,,val
US20120034250A1,CC1CCN(C(=O)OC(C)(C)C)CC1n1ccc2cnc3c(ccn3COCC[Si](C)(C)C)c21.O=C1CCC(=O)N1Br>>C[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1n1ccc2cnc3c(c(Br)cn3COCC[Si](C)(C)C)c21,,ClCCl,,O=C([O-])O.[Na+],,val
US04288443,C=O.COCc1ccoc1CN(C)C>>COCc1cc(CO)oc1CN(C)C,,CC(=O)O,,Cl,O=C([O-])[O-].[Na+].[Na+],val
US04206156,NCCO.O=CO.O=P(O)(O)CCCNO>>NCCO.O=CN(O)CCCP(=O)(O)O,,CCO,,CC(=O)OC(C)=O,,val
US20150344468A1,C=C(c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(Br)cn2)n1>>CC(c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(Br)cn2)n1,[Pt],CCOC(C)=O,CN(C)C=O,,,val
US04155913,O=C1CN=C(c2ccccc2)c2cc(Cl)sc2N1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>S=C1CN=C(c2ccccc2)c2cc(Cl)sc2N1,,COCCOCCOC,,O=C([O-])O.[Na+],,val
US20160060260A1,CC(C)CBr.COc1cc(O)cc(O)c1>>COc1cc(O)cc(OCC(C)C)c1,,CN(C)C=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US20090233900A1,CN1C(=O)CCc2ccc(NC(=O)c3ccc(Cl)cc3NCC3CCCCN3C(=O)OC(C)(C)C)cc21.Cl>>CN1C(=O)CCc2ccc(NC(=O)c3ccc(Cl)cc3NCC3CCCCN3)cc21.Cl,,CCO,,CCOC(C)=O,,val
US06384041B1,CCc1cc2c(Cl)nc(SC)[nH]c-2n1.FC(F)(F)c1cccc(CBr)c1>>CCc1cc2c(Cl)nc(SC)nc2n1Cc1cccc(C(F)(F)F)c1,,C1CCOC1,ClCCl,[H-].[Na+],,val
US20110076291A1,CC1(C)CNC(=O)N1c1nc2c(s1)CCOc1cc(Br)ccc1-2.CI>>CN1CC(C)(C)N(c2nc3c(s2)CCOc2cc(Br)ccc2-3)C1=O,,C1CCOC1,CN(C)C=O,Cl,[H-].[Na+],val
US20110201599A1,CC(C)(C)OC(=O)N1CC(CN)C1.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)N1CC(CNC(=O)OCc2ccccc2)C1,,CCOCC,,c1ccncc1,,val
US04032522,CS(=O)(=O)Cl.Nc1ccc(-c2nc(C(F)(F)F)c[nH]2)cc1>>CS(=O)(=O)Nc1ccc(-c2nc(C(F)(F)F)c[nH]2)cc1,,CC(C)=O,,CCN(CC)CC,,val
US20130252960A1,CC(=O)C(C)=O.Nc1ncnc(Cl)c1N>>Cc1nc2ncnc(O)c2nc1C,,CO,,Cc1ccccc1,,val
US20040171881A1,CCc1cccc(C2(NC[C@@H](O)[C@H](Cc3cc(F)cc(F)c3)NC(=O)CCC(=O)O)CC2)c1.CN(C)C=O.ClCCCl.On1nnc2ccccc21>>CCc1cccc(C2(NC[C@@H](O)[C@H](Cc3cc(F)cc(F)c3)NC(=O)CCC(=O)N[C@@H]3CN4CCC3CC4)CC2)c1.O=CO,,CN(C)C=O,,,,val
US20060100161A1,CC(C)(C)OC(=O)NCCCC(=NNC(=O)c1cc(F)ccc1F)c1ccccc1.CC(C)C(=O)OC(=O)C(C)C>>CC(C)C(=O)N1N=C(c2cc(F)ccc2F)OC1(CCCNC(=O)OC(C)(C)C)c1ccccc1,,ClCCCl,,,,val
US20090227600A1,CC(C)(C)OC(=O)[C@]1(Cc2cscn2)C[C@H](c2cnccn2)[C@H](c2nccs2)N1.COc1cc(C(=O)Cl)ccc1C(C)(C)C>>COc1cc(C(=O)N2[C@@H](c3nccs3)[C@@H](c3cnccn3)C[C@@]2(Cc2cscn2)C(=O)OC(C)(C)C)ccc1C(C)(C)C,,ClCCl,,CCN(CC)CC,,val
US04496584,CCCCCCCCCC(=O)O.CS(=O)(=O)Oc1ccc2cc(C(=N)N)ccc2c1>>CCCCCCCCCC(=O)Oc1ccc2cc(C(=N)N)ccc2c1,,c1ccncc1,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20100286115A1,CNN.COC(=O)C#CC(=O)OC>>COC(=O)/C=C(\C(=O)OC)N(C)N,,CCOCC,,,,val
US05247085,CCOP(=O)(COCCOn1cnc2c(Cl)nc(NC=O)nc21)OCC.N>>CCOP(=O)(COCCOn1cnc2c(N)nc(N)nc21)OCC,,CCO,,,,val
US04728645,CCOC(=O)C=CCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CCOC(=O)CCCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,[Pd],CCO,,,,val
US20130059835A1,CCOc1c(C(C)Cl)cc(C)c(C#N)c1-c1ccc(C(=O)N(C)C)nc1.Cc1n[nH]c2ncnc(N)c12>>CCOc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(C)c(C#N)c1-c1ccc(C(=O)N(C)C)nc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140221311A1,CC(C)(N)CCO.O=S(=O)(Cl)c1ccccc1Br>>CC(C)(CCO)NS(=O)(=O)c1ccccc1Br,,CC#N,,CCN(C(C)C)C(C)C,,val
US20150065519A1,NC(=S)c1ccnc(CCC(F)(F)F)c1.O=C(CBr)c1ccc(NS(=O)(=O)C(F)(F)F)cc1Cl>>O=S(=O)(Nc1ccc(-c2csc(-c3ccnc(CCC(F)(F)F)c3)n2)c(Cl)c1)C(F)(F)F,,CCO,,,,val
US05571813,CN.N#Cc1ccccc1-c1cc2cc(CBr)ccc2o1>>CNCc1ccc2oc(-c3ccccc3C#N)cc2c1,,C1CCOC1,,,,val
US20150133425A1,CC(C)Oc1cc2[nH]ncc2cc1[N+](=O)[O-]>>CC(C)Oc1cc2[nH]ncc2cc1N,[Pd],CCO,,,,val
US20110034516A1,CCOC(=O)c1cc(CO)on1.CS(=O)(=O)Cl>>CCOC(=O)c1cc(CCl)on1,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,N#N,val
US20100113439A1,CC(C)[C@@H](C)[C@@]1(C)CC[C@]2(C)[C@H]3CC[C@@H]4[C@@]5(COC[C@@]4(C)[C@@H](OC[C@](C)(N)C(C)(C)C)[C@H](n4ncnc4-c4ccncc4)C5)C3=CC[C@@]2(C)[C@@H]1C(=O)O.O=C=NC(=O)C(Cl)(Cl)Cl>>CC(C)[C@@H](C)[C@@]1(C)CC[C@]2(C)[C@H]3CC[C@@H]4[C@@]5(COC[C@@]4(C)[C@@H](OC[C@](C)(NC(N)=O)C(C)(C)C)[C@H](n4ncnc4-c4ccncc4)C5)C3=CC[C@@]2(C)[C@@H]1C(=O)O,,CC(Cl)Cl,,CCN(CC)CC,,val
US20100240688A1,O=C1CCC(=O)N1I.O=c1cc(OCc2ccccc2)ccn1CC1CC1>>O=c1c(I)c(OCc2ccccc2)ccn1CC1CC1,,CC(=O)O,,,,val
US04889866,COC(=O)C1=C(C)NC(C)=C(S(=O)c2ccc(OC)cc2)C1c1ccccc1Cl.O=C(OO)c1cccc(Cl)c1>>COC(=O)C1=C(C)NC(C)=C(S(=O)(=O)c2ccc(OC)cc2)C1c1ccccc1Cl,,ClCCl,,,,val
US20080004269A1,C1CCNC1.CCCc1c(Cc2ccnn2-c2ncccc2F)ncn2nc(CCl)nc12>>CCCc1c(Cc2ccnn2-c2ncccc2F)ncn2nc(CN3CCCC3)nc12,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US03932487,CCOC(=O)CCCCCCC1(C(=O)OCC)CCCC1=O>>CCOC(=O)CCCCCCC1=CCCC1=O,,ClC(Cl)Cl,,BrBr,,val
US04870082,NNC(=O)c1cccnc1.O=Cc1ccnc2ccccc12>>O=C(NN=Cc1ccnc2ccccc12)c1cccnc1,,CCO,,,,val
US20080207728A1,CCOC(=O)C(Cc1c[nH]c2cc(F)c(F)cc12)NC(=O)c1cc(-c2cc(F)cc(C(=O)NC)c2)cc2c1OCCCC2>>CNC(=O)c1cc(F)cc(-c2cc3c(c(C(=O)NC(CO)Cc4c[nH]c5cc(F)c(F)cc45)c2)OCCCC3)c1,,C1CCOC1,,CO,[BH4-].[Li+],val
US04046768,Nc1ncc(F)s1.O=C(Cl)Cl>>O=C=Nc1ncc(F)s1,,CCOC(C)=O,,,,val
US20140256782A1,CCC(=O)CCC1(C)C(=O)CCC1=O>>CC1=C2CCC(=O)C2(C)CCC1=O,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20090137530A1,CCCCCCCCOc1ccc(CCC(CO)(CO)NC(=O)OC(C)(C)C)cc1C(F)(F)F.Cl>>CCCCCCCCOc1ccc(CCC(N)(CO)CO)cc1C(F)(F)F.Cl,,ClCCl,,C1COCCO1,,val
US20030166639A1,CCCc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccc(C4CC4)nc3)c2)cc1C(F)(F)F>>CCCc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3ccc(C4CC4)nc3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100204196A1,CNCCOC.COc1cc2c(cc1[N+](=O)[O-])N(C(=O)CBr)CC2>>COCCN(C)CC(=O)N1CCc2cc(OC)c(N)cc21,,ClCCl,O,O=C([O-])[O-].[K+].[K+],,val
US20100121052A1,C#Cc1ccc2nc(Nc3cc(O[C@H]4CCNC4)cc(-c4cnn(C)c4)c3)ncc2c1.CN(C)CC(=O)O>>C#Cc1ccc2nc(Nc3cc(O[C@H]4CCN(C(=O)CN(C)C)C4)cc(-c4cnn(C)c4)c3)ncc2c1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US08163743B2,COc1ncc(-c2cc(NC(=O)c3csc(CN4C[C@H](C)O[C@H](C)C4)n3)c3cnn(S(=O)(=O)c4ccc(C)cc4)c3c2)cc1N.O=S(=O)(Cl)c1cn[nH]c1>>COc1ncc(-c2cc(NC(=O)c3csc(CN4C[C@H](C)O[C@H](C)C4)n3)c3cn[nH]c3c2)cc1NS(=O)(=O)c1cn[nH]c1,,c1ccncc1,,Cl,ClCCl,val
US08822495B2,COc1ccc2c(c1)CCN(c1ccc(N3CCCN(C(=O)OC(C)(C)C)CC3)c(OC)c1)C2=O>>COc1cc(N2CCc3cc(O)ccc3C2=O)ccc1N1CCCNCC1,,Br,,[Na+].[OH-],,val
US04906286,CI.Cc1nn(-c2cc(OC(C)C)c(Cl)cc2Cl)c(=O)[nH]c1=O>>Cc1nn(-c2cc(OC(C)C)c(Cl)cc2Cl)c(=O)n(C)c1=O,,CN(C)C=O,,[H-].[Na+],,val
US04895861,O=C(O)c1ccc2c(Br)cccc2c1>>OCc1ccc2c(Br)cccc2c1,,C1CCOC1,,,,val
US20150175623A1,COc1cc(B2OC(C)(C)C(C)(C)O2)c(C)c(Cl)c1O[Si](C(C)C)(C(C)C)C(C)C>>COc1cc(B2OC(C)(C)C(C)(C)O2)c(C)c(Cl)c1O,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20080027041A1,CC1CC(=O)NN=C1c1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1>>CC1CC(=O)NN=C1c1ccc(OC2CCNCC2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20060293301A1,Cc1ccc2c3c(ccc2n1)OC[C@H](COS(=O)(=O)c1ccc(Br)cc1)O3.Fc1ccc2[nH]cc(CC3CCCNC3)c2c1>>Cc1ccc2c3c(ccc2n1)OCC(CN1CCCC(Cc2c[nH]c4ccc(F)cc24)C1)O3,,CS(C)=O,,CCN(CC)CC,,val
US06605629B1,CCOC(=O)CCCC(O)C(=O)c1ccc(Cl)s1.O=C(Cl)Oc1ccccc1>>CCOC(=O)CCCC(OC(=O)Oc1ccccc1)C(=O)c1ccc(Cl)s1,,C1CCOC1,,c1ccncc1,,val
US04379156,Nc1ncc([N+](=O)[O-])s1.O=C(Cl)c1ccccc1Cl>>O=C(Nc1ncc([N+](=O)[O-])s1)c1ccccc1Cl,,c1ccncc1,,,,val
US20140051676A1,CN(c1ccccc1)c1nc(N)nc(-c2noc(-c3ncccc3F)n2)n1.NCC1CC1>>CN(c1ccccc1)c1nc(N)nc(-c2noc(-c3ncccc3NCC3CC3)n2)n1,,CN(C)C=O,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20150291563A1,CC(=O)C(=O)O.O=Cc1ccc(Br)c(F)c1>>O=C(O)C(=O)C=Cc1ccc(Br)c(F)c1,,CCO,,[Na+].[OH-],,val
US05106526,Cc1ccc(S(=O)(=O)Cl)cc1.OCC(F)(F)C(F)F>>Cc1ccc(S(=O)(=O)OCC(F)(F)C(F)F)cc1,,O,,[Na+].[OH-],,val
US20080132510A1,CC(=O)Cl.CCCc1c(C)ncc(Br)c1N>>CCCc1c(C)ncc(Br)c1NC(C)=O,,ClCCl,,CCN(CC)CC,O=C([O-])O.[Na+],val
US20050154201A1,Cc1cccnc1[C@@H]1CCC[C@H](c2ncccc2C)N1.FC(F)Oc1ccccc1CBr>>Cc1cccnc1[C@@H]1CCC[C@H](c2ncccc2C)N1Cc1ccccc1OC(F)F,,CC#N,,CCN(C(C)C)C(C)C,,val
US20090105214A1,COC(=O)c1cc(O)cc(Oc2ccc3c(c2)OCCN(C)C3=O)c1.COC[C@@H](C)O>>COC[C@H](C)Oc1cc(Oc2ccc3c(c2)OCCN(C)C3=O)cc(C(=O)OC)c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20120258950A1,C=CCC(C(=O)OCC)C(=O)OCC.N=CN>>C=CCc1c(O)nc[nH]c1=O,,CCO,,CC(=O)O,C[O-].[Na+],val
US20040087511A1,CCN=C=NCCCN(C)C.CC[C@@H](C)[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)O.NCc1ccc(N)cc1.On1nnc2ccccc21>>CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)Cc1ccccc1)C(=O)NCc1ccc(N)cc1,,ClCCl,,Cl,,val
US20090023725A1,COc1ccc(-c2noc3cc(Br)ccc23)cc1.Cc1c(F)cc(C(=O)NC2CC2)cc1B(O)O>>COc1ccc(-c2noc3cc(-c4cc(C(=O)NC5CC5)cc(F)c4C)ccc23)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(C)O,,O=C([O-])O.[Na+],,val
US20110118236A1,CC(C)C(=O)C1CCCCC1=O.COC(=O)c1ccc(CNN)cc1>>COC(=O)c1ccc(Cn2nc(C(C)C)c3c2CCCC3)cc1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20050026944A1,Cc1cc(Br)ccc1N.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(Br)ccc1NC(=O)C(F)(F)F,,ClCCl,,,,val
US20130116258A1,CC(=O)N(C)C.CNC(=O)c1ccc(NC2(C#N)CCC2)cc1F.Cc1cc(N=C=S)cnc1C#N>>CNC(=O)c1ccc(N2C(=S)N(c3cnc(C#N)c(C)c3)C(=O)C23CCC3)cc1F,,CC(=O)N(C)C,O,CO,Cl,val
US05166357,CO.ClCc1ncc(C23CCCN(CC2)C3)o1>>COCc1ncc(C23CCCN(CC2)C3)o1,,CO,,Cl,C[O-].[Na+],val
US20070099927A1,CC(=O)OC(C)=O.O=c1c(NCCc2cccnc2)nccn1CCO>>CC(=O)OCCn1ccnc(NCCc2ccccn2)c1=O,CN(C)c1ccncc1,,,CCN(CC)CC,,val
US20040198750A1,COc1ccc(-c2cc(=S)c3cccc(C)c3o2)cc1.NO>>COc1ccc(-c2cc(=NO)c3cccc(C)c3o2)cc1,,c1ccncc1,,Cl,,val
US20160214934A1,CCOC(=O)CCBr.Cc1cc(OCC(C)Cc2c[nH]c3ccccc23)cc(C)c1Cl>>Cc1cc(OCC(C)Cc2cn(CCC(=O)O)c3ccccc23)cc(C)c1Cl,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20140112945A1,COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](Cc4ccccc4)NC(=O)OC(C)(C)C)CC3)C(=O)[C@H]3CCCC[C@@H]23)cc1OC>>COc1ccc(C2=NN(C3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)C(=O)[C@H]3CCCC[C@@H]23)cc1OC,,C1COCCO1,,Cl,,val
US20040053913A1,CC(C)(C)[Si](C)(C)OCCBr.CCOC(=O)c1cc(C(=O)OCC)[nH]n1>>CCOC(=O)c1cc(C(=O)OCC)n(CCO[Si](C)(C)C(C)(C)C)n1,,CC#N,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20070299071A1,CS(=O)(=O)c1ccc(C2=CCOCC2)c(C(=O)O)c1>>CS(=O)(=O)c1ccc(C2CCOCC2)c(C(=O)O)c1,[Pd],CO,,O=C[O-].[NH4+],,val
US20040186301A1,CC(C)(C)OC(=O)CBr.CCOC(=O)CCC(=O)N1C(=O)OCC1Cc1ccccc1>>CCOC(=O)C(CCC(=O)OC(C)(C)C)C(=O)N1C(=O)OCC1Cc1ccccc1,,C1CCOC1,,,,val
US20050101591A1,O=C(c1c(I)ccnc1Cl)N(CCCO)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C1c2c(I)ccnc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1,,C1CCOC1,,O,[H-].[Na+],val
US05811439,CCN(CC)S(F)(F)F.O=C1NC(=O)C(Cc2cccc3c2ccn3CC(O)c2ccccc2)S1>>O=C1NC(=O)C(Cc2cccc3c2ccn3CC(F)c2ccccc2)S1,,O,,CO,ClCCl,val
US05352705,CC[C@H](C)[C@H](NC[C@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(=O)OC(C)(C)C)C(=O)NCCc1ccccc1>>CC[C@H](C)[C@H](NC[C@@H](N)CS)C(=O)NCCc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,CC[SiH](CC)CC,,val
US20130336918A1,Cc1ccc(-c2cnc(NC(=O)c3cc(N4CCCCC4)ccc3N)nc2)cc1C.O=C(O)c1cccc(C(=O)NCCOCCO)c1>>Cc1ccc(-c2cnc(NC(=O)c3cc(N4CCCCC4)ccc3NC(=O)c3cccc(C(=O)NCCOCCO)c3)nc2)cc1C,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US05968958,CCc1csc(Sc2cc3c(cc2[N+](=O)[O-])COC3=O)n1>>CCc1csc(Sc2cc3c(cc2N)COC3=O)n1,[Fe],CCO,O,[Cl-].[NH4+],,val
US20040058903A1,CC(=O)Nc1nccc(CCc2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)n1>>Nc1nccc(CCc2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)n1,,CCO,,Cl,,val
US05304563,COC(=O)C(c1ccc(O)cc1)C1CCCC1.O=[N+]([O-])O>>COC(=O)C(c1ccc(O)c([N+](=O)[O-])c1)C1CCCC1,,ClCCl,,O,,val
US20060084650A1,Cc1cc(Nc2cc(Cl)nc3nccn23)n[nH]1.O=C(Nc1ccc(S)cc1)C1CC1>>Cc1cc(Nc2cc(Sc3ccc(NC(=O)C4CC4)cc3)nc3nccn23)n[nH]1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130116250A1,CCCn1c(=O)n(CCOc2ccc(F)cc2)c(=O)c2cc(C(=O)c3nc(Br)c4ccccn34)ccc21.COC(=O)c1cccc(B(O)O)c1>>CCCn1c(=O)n(CCOc2ccc(F)cc2)c(=O)c2cc(C(=O)c3nc(-c4cccc(C(=O)OC)c4)c4ccccn34)ccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN1CCCC1=O,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],,val
US20130150339A1,COc1cc(C(F)(F)F)ccc1B(O)O.COc1ccc(CN(c2cscn2)S(=O)(=O)c2ccc3c(Cl)nccc3c2)cc1>>COc1ccc(CN(c2cscn2)S(=O)(=O)c2ccc3c(-c4ccc(C(F)(F)F)cc4OC)nccc3c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100286145A1,CC(=O)O.CC=O.COC(=O)c1cc(N)cc(C(=O)OC)c1>>CCN(CC)c1cc(C(=O)OC)cc(C(=O)OC)c1,,CC#N,O,[BH3-]C#N.[Na+],,val
US20130237501A1,Br.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc(N)c(CCO)c3)S(C)(=O)=O)c(C3CC3)cc12>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc(Br)c(CCO)c3)S(C)(=O)=O)c(C3CC3)cc12,[Cu]Br,CC#N,O,O=N[O-].[Na+],,val
US20030191118A1,CCOC(=O)[C@H](Cc1ccc(-c2c(OC)cccc2OC)cc1)NC(=O)c1c(Cl)cccc1Cl>>CCOC(=O)[C@H](Cc1ccc(-c2c(O)cccc2OC)cc1)NC(=O)c1c(Cl)cccc1Cl,,ClCCl,,BrB(Br)Br,,val
US20090286811A1,COc1cccc(C=O)c1OCc1ccccn1.Cc1nc2sccn2c(=O)c1-c1ccc(C(F)(F)F)cc1>>COc1cccc(/C=C/c2cn3c(=O)c(-c4ccc(C(F)(F)F)cc4)cnc3s2)c1OCc1ccccn1,,CCO,,C,C[O-].[Na+],val
US20090176757A1,CC1(C)OO1.N=CC(=O)Cn1c(=O)n(-c2ccccn2)c2ccccc21>>O=CC(=O)Cn1c(=O)n(-c2ccccn2)c2ccccc21,,CC(C)=O,,,,val
US20080070894A1,Brc1cnc2n1CCCC2.C=C(OCC)[Sn](CCCC)(CCCC)CCCC>>CC(=O)c1cnc2n1CCCC2,,Cc1ccccc1,,[F-].[K+],,val
US20090305998A1,CC(C)=O.COc1cccc(-c2ccsc2C=O)n1>>COc1cccc(-c2ccsc2/C=C/C(C)=O)n1,,O,,Cl,[Na+].[OH-],val
US04145432,CCOC(=O)C1=C(C)NC(C=O)=C(C(=O)OCC)C1c1ccccc1[N+](=O)[O-]>>CCOC(=O)C1=C(C)NC(CO)=C(C(=O)OCC)C1c1ccccc1[N+](=O)[O-],,CCO,,Cl,[BH4-].[Na+],val
US20090247526A1,Cc1ncc(C(=O)NCCN(C)C)c(C)c1Oc1cc(Nc2nc(C3CCN(C(=O)OC(C)(C)C)CC3)ns2)ncc1Br.Cl.ClCCl>>Cc1ncc(C(=O)NCCN(C)C)c(C)c1Oc1cc(Nc2nc(C3CCNCC3)ns2)ncc1Br.Cl.Cl,,CO,,,,val
US05843983,CCCCCCCCOC(=O)N1C[C@H](OC(=O)N(C)C)C[C@H]1CCOc1cc(Cl)ccc1CCc1ccccc1>>CN1C[C@H](O)C[C@H]1CCOc1cc(Cl)ccc1CCc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030096838A1,CCN(CC)CC.CN(C)C=O.CNOC.O=C(Cl)C(=O)Cl>>CON(C)C(=O)c1ccc(Cl)nc1,,ClCCl,,Cl,,val
US20120101110A1,Cc1cc(C)nc(Cl)n1.O=C1NCCCC12CCNCC2>>Cc1cc(C)nc(N2CCC3(CCCNC3=O)CC2)n1,CN(C)c1ccncc1,CCO,,CCN(C(C)C)C(C)C,,val
US20120232056A1,COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCN(C(=O)OC(C)(C)C)C[C@@H]3C)nc2c1>>C[C@H]1CNCCN1c1nc2cc(C(=O)O)ccc2nc1-c1ccc(F)cc1,,ClCCl,O,O=C(O)C(F)(F)F,[Na+].[OH-],val
US06048875,COc1cc2sc(C(=O)Cl)c(Cl)c2cc1OC.O>>COc1cc2sc(C(=O)O)c(Cl)c2cc1OC,,C1COCCO1,,,,val
US04585591,C#C[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3CC[C@@]21C>>C#CC1=CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C,,c1ccccc1,,,,val
US20100035756A1,COC(=O)c1ccc(C(F)(F)F)nc1NN.O=C(Cl)Cl>>COC(=O)c1ccc(C(F)(F)F)n2c(O)nnc12,,Cc1ccccc1,,,,val
US20140296315A1,CCOC(=O)CCCOc1cc(Cl)c2c(c1)C(=O)c1ccccc1-2.C[Si](C)(C)C(F)(F)F>>CCOC(=O)CCCOc1cc(Cl)c2c(c1)[C@@](O)(C(F)(F)F)c1ccccc1-2,,C1CCOC1,,CC(=O)O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20060160864A1,CC1CCCCN1.O=Cc1cc(Br)ccc1F>>CC1CCCCN1c1ccc(Br)cc1C=O,,CS(C)=O,O,O=C([O-])[O-].[Na+].[Na+],,val
US04319033,CCC(S)CS.CCCC(=O)C(O)CCC>>CCCC1=C(CCC)SC(CC)CS1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04783459,Cc1cc(C)nc(Nc2ccccc2)n1.O=C(Cl)C(Cl)(Cl)Cl>>Cc1cc(C)nc(N(C(=O)C(Cl)(Cl)Cl)c2ccccc2)n1,,Cc1ccccc1,,[H][H],[H-].[Na+],val
US20090209522A1,CCOC(=O)c1csc(Oc2cc(C(C)(C)C)ccc2C)n1.COc1nc(OCCOC(C)(C)C)nc(OC)c1N>>COc1nc(OCCOC(C)(C)C)nc(OC)c1NC(=O)c1csc(Oc2cc(C(C)(C)C)ccc2C)n1,,ClCCl,,CCN(CC)CC,,val
US20080119511A1,COC(=O)C[C@@H](c1ccc(Oc2ccc3c(c2)CCCC3)cc1)c1nncn1C>>Cn1cnnc1[C@@H](CC(=O)O)c1ccc(Oc2ccc3c(c2)CCCC3)cc1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20100137317A1,COC(=O)C(C)(C)NC(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1>>CC1(C)NC(=O)C(c2ccc(OCc3ccc4ccccc4n3)cc2)=C1O,,CN(C)C=O,,[H-].[Na+],,val
US20080004271A1,COc1cncc(-c2nc(SC)[nH]c(=O)c2C#N)c1.O=P(Cl)(Cl)Cl>>COc1cncc(-c2nc(SC)nc(Cl)c2C#N)c1,,C1COCCO1,,,,val
US20030130255A1,CN(Cc1ccccc1)c1cc(CN2CCOCC2)ccc1[N+](=O)[O-]>>CN(Cc1ccccc1)c1cc(CN2CCOCC2)ccc1N,[Pd],CCOC(C)=O,,[H][H],,val
US20140296208A1,COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)c3)c(F)c2F)cc(C(C)(C)C)cc1C(=O)O.NC1COC1>>COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)c3)c(F)c2F)cc(C(C)(C)C)cc1C(=O)NC1COC1,,CN(C)C=O,O,CCN(CC)CC,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04838924,CCOC(=O)COc1cc(OCc2ccccc2)ccc1C(=O)CC>>CCC(=O)c1ccc(OCc2ccccc2)cc1OCC(=O)O,,CO,,[K+].[OH-],,val
US05739345,O=C1SC(Cc2ccc(OCCn3ccc4cccnc43)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1>>O=C1NC(=O)C(Cc2ccc(OCCn3ccc4cccnc43)cc2)S1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080312226A1,O=C=Nc1ccc2c(c1)CCO2.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>O=C(Nc1ccc2c(c1)CCO2)N1CCN(c2nc(-c3ccccc3)ns2)CC1,,C1CCOC1,,CCN(CC)CC,,val
US20140274696A1,II.Nc1cc(F)cc(F)c1F>>Nc1cc(F)c(I)c(F)c1F,,C1CCOC1,,[Li]C(C)CC,,val
US20120010191A1,C=O.Cn1cc(Br)cc(Nc2ccc(N3CCNCC3=O)cn2)c1=O>>CN1CCN(c2ccc(Nc3cc(Br)cn(C)c3=O)nc2)C(=O)C1,,CO,,CC(=O)O,[Na+].[OH-],val
US20100298301A1,N#Cc1nc(-c2c(F)cccc2F)oc1Nc1ccc([N+](=O)[O-])cc1>>N#Cc1nc(-c2c(F)cccc2F)oc1Nc1ccc(N)cc1,[Pd],CCOC(C)=O,,CO,,val
US20140135322A1,COC(=O)Cc1ccsc1-c1ccc(S(C)(=O)=O)cc1.O=C1CCC(=O)N1Br>>COC(=O)Cc1cc(Br)sc1-c1ccc(S(C)(=O)=O)cc1,,CO,ClC(Cl)Cl,CC(=O)O,,val
US20140323418A1,CCN.CSc1ncc(C(N)=O)c(Nc2cccc(-n3nccn3)c2)n1>>CCNc1ncc(C(N)=O)c(Nc2cccc(-n3nccn3)c2)n1,,CCOC(C)=O,CN1CCCC1=O,O=C(OO)c1cccc(Cl)c1,,val
US20100249182A1,CC(=O)Nc1cccc2c(Oc3cc(N(C(=O)[O-])C(C)(C)C)ccc3C)ccnc12>>CC(=O)Nc1cccc2c(Oc3cc(N)ccc3C)ccnc12,,ClCCl,O=C(O)C(F)(F)F,[Na+].[OH-],,val
US05462941,O=P(Cl)(Cl)Cl.O=c1[nH]nc(-c2ccco2)c2ccccc12>>Clc1nnc(-c2ccco2)c2ccccc12,,CC(Cl)Cl,,,,val
US20160038504A1,Cc1ncc(N)cc1-c1cc(F)nc(F)c1.NCCO>>Cc1ncc(N)cc1-c1cc(F)nc(NCCO)c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130040930A1,CCOC(=O)c1ccc(N)cc1.O=C=NCCCCl>>CCOC(=O)c1ccc(NC(=O)NCCCCl)cc1,,ClCCl,,O,c1ccncc1,val
US07179823B1,CCOC(=O)CCc1cn(Cc2ccc(O)cc2)cc1-c1ccccc1.Cc1ncccc1CCl>>CCOC(=O)CCc1cn(Cc2ccc(OCc3cccnc3C)cc2)cc1-c1ccccc1,,CN(C)C=O,,O,[H-].[Na+],val
US20120171245A1,CCOC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=C1CCC[C@H](Nc2nc(Cl)ncc2F)C1>>CCOC(=O)C=C1CCC[C@H](Nc2nc(Cl)ncc2F)C1,,Cc1ccccc1,,,,val
US20160113928A1,Cn1nccc1-c1nnc(N2CCC(N)CC2)c2ccccc12.O=C=Nc1ccc(F)cc1C(F)(F)F>>Cn1nccc1-c1nnc(N2CCC(NC(=O)Nc3ccc(F)cc3C(F)(F)F)CC2)c2ccccc12,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20140315917A1,Clc1ccnc(Cl)c1.Nc1ccc(O)c(Cl)c1F>>Nc1ccc(Oc2ccnc(Cl)c2)c(Cl)c1F,,CC(=O)N(C)C,,CC(C)(C)[O-].[K+],,val
US20050143443A1,CCOC(=O)c1cc(CCCC(C)C)[nH]n1>>CC(C)CCCc1cc(C(=O)O)n[nH]1,,CO,,[Na+].[OH-],,val
US20070105904A1,CN(C)C=O.Fc1cccnc1OCc1ccc(Br)cc1>>O=Cc1ccc(COc2ncccc2F)cc1,,O,,C1CCOC1,[Li]CCCC,val
US20100240641A1,CC(C)(C)[SiH2]OC(C)(C)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.COc1cc(C#N)ccc1CBr>>COc1cc(C#N)ccc1Cn1cncc1C(C)(C)O[SiH2]C(C)(C)C,,CC#N,,,,val
US20090023725A1,CCNC(=O)c1cc(F)c(C)c(-c2ccc3c(I)n[nH]c3c2)c1.OB(O)c1ccc(C(F)(F)F)cc1>>CCNC(=O)c1cc(F)c(C)c(-c2ccc3c(-c4ccc(C(F)(F)F)cc4)n[nH]c3c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(C)O,,O=C([O-])O.[Na+],,val
US05130335,CC1(C)CCC(C)(C)O1.Oc1ccccc1>>CC1(C)CCC(C)(C)c2cc(O)ccc21,,CCCCCCC,,Cl,[Al+3].[Cl-].[Cl-].[Cl-],val
US06689808B2,CCCCC1OC(=O)c2cc(N)c([N+](=O)[O-])cc21>>CCCCC1OC(=O)c2cc(N)c(N)cc21,[Ni],CCO,,[H][H],,val
US20100120841A1,O=C1Cc2ccc(Br)c3cccc1c23>>OC1Cc2ccc(Br)c3cccc1c23,,CO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20110009454A1,NCc1ccc(F)cc1.Nc1ncccc1C(=O)O>>Nc1ncccc1C(=O)NCc1ccc(F)cc1,,CN(C)C=O,O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US04550169,CSC1=NCCN1.I.NNCC(F)(F)F>>FC(F)(F)CNNC1=NCCN1.I,,CCO,,,,val
US20050187236A1,CCN(CC)CCCN.CNC(=O)n1cc(Cl)c2cc(Oc3ccnc(NC(=O)Oc4ccccc4)c3)ccc21>>CCN(CC)CCCNC(=O)Nc1cc(Oc2ccc3c(c2)c(Cl)cn3C(=O)NC)ccn1,,CCOC(C)=O,,CN(C)C=O,O=C([O-])O.[Na+],val
US20130345252A1,COC(=O)CCCCC(=O)Nc1ccc2c3c(n(CCCNC(=O)OC(C)(C)C)c(=O)c2c1)-c1ccccc1C3=O>>COC(=O)CCCCC(=O)Nc1ccc2c3c(n(CCCN)c(=O)c2c1)-c1ccccc1C3=O,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20090176792A1,O=S(Cl)Cl.OC(c1ccccc1)c1ccccc1>>ClC(c1ccccc1)c1ccccc1,,ClCCl,,,,val
US20120202690A1,COc1c(Cl)ccc(-c2nc(-c3ccco3)c3ncn(Cc4ccccc4)c3n2)c1F.O=[O+][O-]>>COc1c(Cl)ccc(-c2nc(C(=O)O)c3ncn(Cc4ccccc4)c3n2)c1F,,ClCCl,,,,val
US20100081671A1,CC(C)(C)OC(=O)N[C@@H]1CC[C@H](Oc2ccc3cnccc3c2Cl)CC1>>N[C@@H]1CC[C@H](Oc2ccc3cnccc3c2Cl)CC1,,CCO,,,,val
US20090042890A1,CCOC(=O)c1nc(Nc2ccccc2CO)nc(Nc2ccccc2OC)c1N.CCOC(=O)c1nc(Nc2ccccc2CO)nc(Nc2ccccc2OC)c1[N+](=O)[O-]>>COc1ccccc1-n1c(=O)[nH]c2c(C(N)=O)nc(Nc3ccccc3CO)nc21,[Pd],,,CCO,,val
US05140031,N#CN.S=C=Nc1ccccc1>>N#CNC(=S)Nc1ccccc1,,CCO,,[Na],,val
US20120270863A1,COC(=O)C1=Cc2cc(OC)c(OC)cc2C1>>COc1cc2c(cc1OC)CC(C(=O)O)=C2,,C1CCOC1,CO,[Na+].[OH-],,val
US20150119394A1,c1ccc(CN2CCO[C@H](COc3ccc(-c4cccnc4)cc3)C2)cc1>>c1cncc(-c2ccc(OC[C@@H]3CNCCO3)cc2)c1,[Pd],,,O=C[O-].[NH4+],,val
US20020086890A1,CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OCC)CCN(Cc3ccc(Br)cc3)CC2)cc1>>CC#CCOc1ccc(S(=O)(=O)C2(C(=O)O)CCN(Cc3ccc(Br)cc3)CC2)cc1,,C1CCOC1,,CO,[Na+].[OH-],val
US20050107428A1,CS(=O)(=O)c1ccccc1C(=O)O.NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1>>CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US04985432,CCOC(=O)C(C)=CO.Nc1nnc(SCc2ccccc2)s1>>Cc1cnc2sc(SCc3ccccc3)nn2c1=O,,O,,,,val
US20100216814A1,CCC1(c2ccncc2)CO1.CN1CCc2[nH]c3ccc(Cl)cc3c2C1>>CCC(O)(Cn1c2c(c3cc(Cl)ccc31)CN(C)CC2)c1ccncc1,,CN(C)C=O,,[H-].[Na+],,val
US20160128326A1,C#CCBr.COC1=C(c2cc(-c3ccc(Cl)cc3)ccc2C)C(=O)CC1>>C#CCC1CC(OC)=C(c2cc(-c3ccc(Cl)cc3)ccc2C)C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[K+],,val
US20060013869A1,CC[C@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1>>CC[C@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1,,C1CCOC1,,CCO,Cl,val
US04104386,CCO.CN(C)c1ccc(C#N)nn1.O>>CCOC(=O)c1ccc(N(C)C)nn1,,ClCCl,,[Na+].[OH-],,val
US04122186,ClCc1ccc(Cl)cc1Cl.NC(N)=S.O=C([O-])CCl>>OC(=S)CCc1ccc(Cl)cc1Cl,,O,,[Na+].[OH-],,val
US20130190268A1,CI.COC(=O)CCCCCNC(=O)OC(C)(C)C>>COC(=O)CCCCCN(C)C(=O)OC(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20140088101A1,COC(=O)c1nc(C#N)c2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O.NCc1ccncc1>>N#Cc1nc(C(=O)NCc2ccncc2)c(O)c2cc(-c3ccccc3)c(=O)n(Cc3ccccc3)c12,,CCO,,CC(=O)O,O,val
US20090233903A1,CCOP(=O)(CC#N)OCC.N#CC1(CF)CC(=O)C1>>N#CC=C1CC(C#N)(CF)C1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20110230478A1,CNCCOC.Clc1cnc(Nc2ccccc2)nc1Cl>>COCCN(C)c1nc(Nc2ccccc2)ncc1Cl,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20130131035A1,CC(C)(C)OC(=O)N1CC(Oc2ccc(Cl)cc2Cl)C1>>Clc1ccc(OC2CNC2)c(Cl)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20080300308A1,COC(=O)CCNC(=O)c1ccc(C(CC(C)C)Nc2ccc(-c3ccc(C(C)(C)C)cc3)cc2)cc1>>CC(C)CC(Nc1ccc(-c2ccc(C(C)(C)C)cc2)cc1)c1ccc(C(=O)NCCC(=O)O)cc1,,CCOC(C)=O,,CO,[Na+].[OH-],val
US20050187390A1,CC(=O)c1cnn(-c2ccccc2)c1.O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4cc(Br)ccc4O)ccc3c1)n2C1CCCCC1>>O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4cnn(-c5ccccc5)c4)ccc3c1)n2C1CCCCC1,,CCO,,[K+].[OH-],,val
US20070135631A1,[N-]=[N+]=NC(c1cccc(OC(F)(F)F)c1)(c1cccc(OC(F)(F)F)c1)[C@@H](O)c1ccccc1>>NC(c1cccc(OC(F)(F)F)c1)(c1cccc(OC(F)(F)F)c1)[C@@H](O)c1ccccc1,[Pd],CO,,,,val
US06433175B1,COc1ccc2[nH]cc(C=O)c2c1.ClCCCCBr>>COc1ccc2c(c1)c(C=O)cn2CCCCCl,,CS(C)=O,,[K+].[OH-],,val
US20130317221A1,Cc1cc(C#Cc2ccc(C(C)(C)C)cc2)ccc1-n1c(C)nc2ccccc2c1=O.O=Cc1ccc(O)cc1O>>CC(C)(C)c1ccc(C#Cc2ccc(-n3c(/C=C/c4ccc(O)cc4O)nc4ccccc4c3=O)cc2)cc1,,CC(=O)O,,,,val
US20080139663A1,CC(C)CC(NC(=O)OC(C)(C)C)C1(c2ccc(O)cc2)CCC1.CCOC(=O)CBr>>CCOC(=O)COc1ccc(C2(C(CC(C)C)NC(=O)OC(C)(C)C)CCC2)cc1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060270853A1,CC(C)(C)OCC(O)(CF)CC(=O)OC(C)(C)C>>O=C1CC(O)(CF)CO1,,O=C(O)C(F)(F)F,,,,val
US20080045528A1,O=C(O)c1cnccc1Cl.O=S(Cl)Cl>>Cl.O=C(Cl)c1cnccc1Cl,,Cc1ccccc1,,,,val
US04223035,CC(=O)c1cccs1.CCC(CC)(c1ccccc1C#N)P(=O)([O-])[O-]>>CC(=Cc1ccccc1C#N)c1cccs1,,CN(C)C=O,,C[O-].[Na+],,val
US06172085B2,Cc1c(C)c2c(c(C)c1NC(=O)OC(C)(C)C)CC(C)(CCBr)O2.c1ccc(C(OC2CCNCC2)c2ccccc2)cc1>>Cc1c(C)c2c(c(C)c1NC(=O)OC(C)(C)C)CC(C)(CCN1CCC(OC(c3ccccc3)c3ccccc3)CC1)O2,,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],,val
US20040110832A1,COC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cc(Br)ccc1OCc1ccc(OCc2ccccc2)cc1>>O=C(N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)O)c1cc(Br)ccc1OCc1ccc(OCc2ccccc2)cc1,,C1CCOC1,CO,[Li+].[OH-],,val
US20160221948A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C1CCCNC1c1ccccc1>>CCOC(=O)C1CCCN(C(=O)OC(C)(C)C)C1c1ccccc1,,C1CCOC1,,[Na+].[OH-],,val
US20060094761A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ncc(CO)c(CNCCCCCC(=O)O)c1O>>Cc1ncc(CO)c(CN(CCCCCC(=O)O)C(=O)OC(C)(C)C)c1O,,C1COCCO1,CO,,,val
US20130150357A1,CC(C)(N)CO.COC(=O)[C@@H](C)OS(=O)(=O)C(F)(F)F>>C[C@@H]1NC(C)(C)COC1=O,,ClCCl,,CCOC(C)=O,O=C([O-])O.[Na+],val
US20090233908A1,CC(C)(C)OC(=O)NC1CCCN(C(=O)OCc2ccccc2)C1CCN=[N+]=[N-].Cl>>Cl.[N-]=[N+]=NCCC1C(N)CCCN1C(=O)OCc1ccccc1,,CO,,C1COCCO1,,val
US20090124666A1,ClC(Cl)(Cl)C(Cl)(Cl)Cl.N#Cc1ncoc1-c1ccc(C(F)(F)F)cc1>>N#Cc1nc(Cl)oc1-c1ccc(C(F)(F)F)cc1,,C1CCOC1,O,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20100152160A1,CC(C)(C)OC(=O)N1CC(C(=O)N2CCC(C#N)(Cc3ccc(F)cc3)CC2)Oc2c(Br)cc(Cl)cc21.OB(O)c1ccncc1>>CC(C)(C)OC(=O)N1CC(C(=O)N2CCC(C#N)(Cc3ccc(F)cc3)CC2)Oc2c(-c3ccncc3)cc(Cl)cc21,,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100311966A1,CC[C@@H](Br)[C@H]1CO1.NC(c1ccccc1)c1ccccc1>>CC[C@H]1[C@H](O)CN1C(c1ccccc1)c1ccccc1,,CO,,,,val
US20160200695A1,COc1ccc2nc(NC(=O)c3ccc([C@@H](N[S@](=O)C(C)(C)C)c4ccccc4)cc3)sc2c1.Cl>>COc1ccc2nc(NC(=O)c3ccc([C@@H](N)c4ccccc4)cc3)sc2c1.Cl,,CO,,,,val
US05348965,CCOC(=O)[C@@H]1CCCN(CCOCCC2Cc3ccccc3CNc3ccccc32)C1.Cl>>Cl.O=C(O)[C@@H]1CCCN(CCOCCC2Cc3ccccc3CNc3ccccc32)C1,,CCO,,[Na+].[OH-],,val
US20110144066A1,CCCCCCCCCC(=O)Cl.Nc1ccc(S(=O)(=O)Nc2nncs2)cc1>>CCCCCCCCCC(=O)Nc1ccc(S(=O)(=O)Nc2nncs2)cc1,,c1ccncc1,,Cl,,val
US20050075384A1,COC(=O)c1nc(OC(C)=O)n(C(C)=O)c1C.O=C1CCC(=O)N1Br>>COC(=O)c1nc(OC(C)=O)n(C(C)=O)c1CBr,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)(Cl)Cl,,,,val
US03953500,CCOC(=O)c1cccc2c1CCCC2C#N>>N#CC1CCCc2c(C(=O)O)cccc21,,O,,CCO,[Na+].[OH-],val
US20030036652A1,Nc1ccc(S(=O)(=O)C(F)(F)F)cc1N.O=C(n1ccnc1)n1ccnc1>>O=c1[nH]c2ccc(S(=O)(=O)C(F)(F)F)cc2[nH]1,,CC#N,,,,val
US05110956,CCOC(=O)CS.CCc1cc2c(cc1C(O)CC)OCO2>>CCOC(=O)CSC(CC)c1cc2c(cc1CC)OCO2,Cc1ccc(S(=O)(=O)O)cc1,c1ccccc1,,O,,val
US04962102,Cc1ccc(Sc2nc(Cl)c([N+](=O)[O-])s2)cc1.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(S(=O)c2nc(Cl)c([N+](=O)[O-])s2)cc1,,ClCCl,,,,val
US06350749B1,CC(=O)CCl.Cc1ccc(C)c(C2CC(=O)CC(=O)C2)c1>>Cc1ccc(C)c(C2CC(=O)c3c(C)coc3C2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20080119458A1,COC(=O)c1ccc(-n2cnc3ccccc32)cc1>>O=C(O)c1ccc(-n2cnc3ccccc32)cc1,,C1CCOC1,CO,[Na+].[OH-],,val
US20100075946A1,CCCc1sc(C(=O)N(C)OC)cc1-c1ccccc1.C[Mg]Br>>CCCc1sc(C(C)=O)cc1-c1ccccc1,,O,,,,val
US20100286170A1,Cc1cc(Br)cc(C)[n+]1[O-].O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(Br)cc(COC(=O)C(F)(F)F)n1,,ClCCl,,,,val
US20120157439A1,CCCS(=O)(=O)Cl.COC(=O)c1cc(Cl)cc(N)c1F>>CCCS(=O)(=O)Nc1cc(Cl)cc(C(=O)O)c1F,,C1CCOC1,,CCN(CC)CC,[Na+].[OH-],val
US20110190343A1,COC(=O)c1cccc(CBr)c1.OB(O)c1ccc2[nH]ccc2c1>>COC(=O)c1cccc(Cc2ccc3[nH]ccc3c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1CCOC1,O=C([O-])[O-].[K+].[K+],val
US20110039823A1,CC(C)(C)OC(=O)NCC1CNC1.COc1ccc2nccc(Br)c2n1>>COc1ccc2nccc(N3CC(CNC(=O)OC(C)(C)C)C3)c2n1,,CCCCCO,,,,val
US05138069,CCOC(=O)CNCc1ccc(OCc2ccccc2)cc1.O=CO>>CCOC(=O)CN(C=O)Cc1ccc(OCc2ccccc2)cc1,,Cc1ccccc1C,,,,val
US20150218141A1,FC(F)(F)[C@@H]1CO1.FC(F)(F)c1cc(C2CCCNC2)cc(C(F)(F)F)c1>>O[C@@H](CN1CCCC(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1)C(F)(F)F,,CC#N,,,,val
US20150376130A1,CCOC(=O)c1cccnc1NCC(F)(F)F.O=C1CCC(=O)N1Cl>>CCOC(=O)c1cc(Cl)cnc1NCC(F)(F)F,,O,,CN(C)C=O,Cl,val
US20110003787A1,COC[C@H](C)Oc1cc(O[Si](C(C)C)(C(C)C)C(C)C)cc(-c2ccc(C(=O)O)[nH]2)c1.C[C@@H](O)[C@@H](N)CO>>COC[C@H](C)Oc1cc(O[Si](C(C)C)(C(C)C)C(C)C)cc(-c2ccc(C(=O)N[C@@H](CO)[C@@H](C)O)[nH]2)c1,,CO,,COc1nc(OC)nc([N+]2(C)CCOCC2)n1.[Cl-],,val
US05378689,CC(C)[C@H]1COC(=O)N1C(=O)[C@@H](CC(=O)OCc1ccccc1)Cc1ccccc1.CNCc1ccccc1>>CC(C)[C@H]1COC(=O)N1C(=O)[C@@H](CC(=O)N(C)Cc1ccccc1)Cc1ccccc1,[Pd],CCO,,CCN(CC)CC,CCOP(=O)(C#N)OCC,val
US20050131017A1,Cc1cccc(CN2CCN([C@H](C(=O)N[C@@H](Cc3ccc(-c4ccccn4)cc3)[C@@H](O)C[C@H](Cc3ccccc3)NC(=O)OC(C)(C)C)C(C)(C)C)C2=O)n1>>Cc1cccc(CN2CCN([C@H](C(=O)N[C@@H](Cc3ccc(-c4ccccn4)cc3)[C@@H](O)C[C@@H](N)Cc3ccccc3)C(C)(C)C)C2=O)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20050070441A1,CCN=C=O.FC(F)(F)c1cnc(Oc2cc(C(F)(F)F)[nH]n2)c(Cl)c1>>CCNC(=O)n1nc(Oc2ncc(C(F)(F)F)cc2Cl)cc1C(F)(F)F,,CCOC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20060177621A1,CC(=O)C1C(=O)CC(C)OC1=O.COC(OC)N(C)C>>CC1CC(=O)C(=C(O)C=CN(C)C)C(=O)O1,,COC(C)(C)C,,,,val
US20080051418A1,CC(C)Oc1cc(Cc2ccccn2)ccc1O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)Oc1cc(Cc2ccccn2)ccc1OS(=O)(=O)C(F)(F)F,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20080269267A1,CCCn1cc(B2OC(C)(C)C(C)(C)O2)cn1.Nc1ccc(Oc2ccnc(Cl)c2)cc1F>>CCCn1cc(-c2cc(Oc3ccc(N)c(F)c3)ccn2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCOC(C)=O,COCCOC,O,O=C([O-])[O-].[K+].[K+],val
US05576322,COc1ccc2nc(COCc3ccccc3)[nH]c(=O)c2c1.O=P(Cl)(Cl)Cl>>COc1ccc2nc(COCc3ccccc3)nc(Cl)c2c1,,CC#N,,,,val
US06096753,CCOP(=O)(CC#N)OCC.Cc1ccccc1C=O.Cc1ccccc1CCCN>>C=C(C#N)c1ccccc1C,,C1CCOC1,,[H-].[Na+],,val
US20100261719A1,C[C@H]1CN(c2ccc([N+](=O)[O-])cc2C=O)C[C@@H](C)O1.O=C1CC(=O)NC(=O)N1>>C[C@@H]1CN2c3ccc([N+](=O)[O-])cc3CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1,,CC(C)O,,O,,val
US20150291573A1,C=CCC(C)(C)O.CS(=O)(=O)O.O=Cc1ccc(Cl)cc1>>CC1(C)CC(OS(C)(=O)=O)CC(c2ccc(Cl)cc2)O1,,ClCCl,,O=C([O-])[O-].[Na+].[Na+],,val
US05859009,CCOCC(O)CO.CCc1ncnc(NC2CCC3(CC2)OCCO3)c1Cl>>CCOCC1COC2(CCC(Nc3ncnc(CC)c3Cl)CC2)O1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20130089512A1,CC(C)(C)OC(=O)N1CCC(n2c(=O)[nH]c3ccc(-c4cnc5ccc(F)cn45)nc32)CC1>>O=c1[nH]c2ccc(-c3cnc4ccc(F)cn34)nc2n1C1CCNCC1,,Cl,,,,val
US20110312936A1,CC(C)(C)OC(=O)N1CC(N)C1.CN(CC(=O)[O-])C(=O)OCc1ccccc1>>CN(CC(=O)NC1CN(C(=O)OC(C)(C)C)C1)C(=O)OCc1ccccc1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,,val
US04286105,CC(C)(O)C(=O)Nc1ccc(Nc2ccccc2)cc1>>C=C(C)C(=O)Nc1ccc(Nc2ccccc2)cc1,,O=S(=O)(O)O,,O,,val
US20150315197A1,CC(C)(C)OC(=O)N1CC=C(c2ccc(F)cc2C(F)(F)F)CC1>>CC(C)(C)OC(=O)N1CCC(c2ccc(F)cc2C(F)(F)F)CC1,O=[Pt]=O,CCOC(C)=O,,N#N,,val
US04992433,CCOC(=O)N1CCC(C=CC(=O)O)C1>>CCOC(=O)N1CCC(CCC(=O)O)C1,[Pd],CC(=O)O,,[H][H],,val
US05344828,CCOC(=O)CN1CCN2c3ccccc3Cc3ccccc3C2C1>>O=C(O)CN1CCN2c3ccccc3Cc3ccccc3C2C1,,CO,,[Na+].[OH-],,val
US20090312241A1,COC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NCCCCC=Cc1cccc(c1)-c1cccc(c1)CO2>>COC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NCCCCCCc1cccc(c1)-c1cccc(c1)CO2,[Pd],CO,,O=C(O)C(F)(F)F,,val
US06245761B1,CN(C)CCO.Fc1ccc(Br)cc1CBr>>CN(C)CCOCc1cc(Br)ccc1F,,CN(C)C=O,,[H-].[Na+],,val
US20100160682A1,CCOC(=O)CCCc1cccc(F)c1>>O=C(O)CCCc1cccc(F)c1,,O,,[Na+].[OH-],,val
US20100239526A1,CC(C)(C)OC(=O)N1CCc2c(cnc3[nH]nc(Br)c23)C1.O=C(O)C(F)(F)F>>Brc1n[nH]c2ncc3c(c12)CC[NH2+]C3.O=C([O-])C(F)(F)F,,C1COCCO1,,Cc1ccccc1,,val
US20140256945A1,CCOC(=O)c1ccc(C#CCCCCc2ccccc2)c(F)c1>>OCc1ccc(C#CCCCCc2ccccc2)c(F)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05135938,BrCCCCCCCCc1ccccc1.COc1ccccc1C1=NC(C)(C)CO1>>CC1(C)COC(c2ccccc2CCCCCCCCc2ccccc2)=N1,,C1CCOC1,,[Mg],,val
US20080280961A1,CCOC(=O)CO.Clc1nc2ccccc2o1>>CCOC(=O)COc1nc2ccccc2o1,,C1CCOC1,,[H-].[Na+],,val
US20060030613A1,CC(C)(C)c1ccc(C=O)cc1.CCCCN>>CCCCNCc1ccc(C(C)(C)C)cc1,Cl,CO,,[BH4-].[Na+],,val
US20100035883A1,CCOC(=O)c1cccc2c1C(=O)C(c1ccoc1)C(c1ccccc1)N2.NN>>O=c1[nH]nc2c3c(cccc13)NC(c1ccccc1)C2c1ccoc1,,CO,,O,,val
US20070066624A1,COC(=O)c1ccc(N)cc1.Clc1ncc(Br)cn1>>COC(=O)c1ccc(Nc2ncc(Br)cn2)cc1,,C1CCOC1,,CC(C)(C)O[K],,val
US05506267,C=CS(=O)(=O)NCc1ccc(C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>C=CS(=O)(=O)N(Cc1ccc(C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1)C(=O)OC(C)(C)C,,c1ccncc1,,,,val
US20080021022A1,Cc1noc(CC(=O)c2ccccc2)c1C(=O)O.c1ccc2c(c1)CCNC2>>Cc1noc(CC(=O)c2ccccc2)c1C(=O)N1CCc2ccccc2C1,,CN(C)C=O,ClC(Cl)Cl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20090124577A1,CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1)[C@H](C(=O)OC)C(C)C>>CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)OC)C(C)C,,CO,,Cl,,val
US20110312945A1,C=C(CCl)OCOC.O=C1CCCCCC1>>CC(=O)CC1CCCCCC1=O,,Cc1ccccc1,,[H-].[Na+],,val
US20100160324A1,COC(=O)c1nn(C2CCCCO2)cc1[N+](=O)[O-].NN>>NNC(=O)c1nn(C2CCCCO2)cc1[N+](=O)[O-],,CCO,,O,,val
US20060167040A1,Cn1cc2c(-c3ccc(OCc4ccccc4)cc3)c(-c3ccncc3)c(-c3ccc(F)cc3)nc2n1>>Cn1cc2c(-c3ccc(O)cc3)c(-c3ccncc3)c(-c3ccc(F)cc3)nc2n1,[Pd],CCO,,,,val
US04338319,CCn1c(N)cc(=O)[nH]c1=O.O=N[O-]>>CCn1c(N)c(N=O)c(=O)[nH]c1=O,,O,,Cl,,val
US03966916,COc1ccc(Cl)cc1CNCCO.OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O>>COc1ccc(Cl)cc1CN(CCO)c1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O,,CCCCO,,CCN(CC)CC,,val
US05409922,CC(=O)OC(C=O)(C(=O)OC(C)(C)C)C(N)Cc1ccccc1.CC(C)C[Mg]Cl>>CC(C)C[C@H](O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C,,C1CCOC1,CCOCC,CO,O,val
US20150152102A1,FC(F)(F)c1ccc(Cl)nn1.O=C1CC(O)(C(F)(F)F)c2c(C3CCNCC3)n[nH]c2N1>>O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(C(F)(F)F)nn4)CC3)n[nH]c2N1,,CCOC(C)=O,CS(C)=O,CCN(C(C)C)C(C)C,Cl,val
US04007189,CC(C)(C)N.Cc1nc2ncnn2c(Cl)c1CC(C)Cl.Cl>>Cc1nc2ncnn2c2c1CC(C)N2C(C)(C)C.Cl,,CCO,,O=C([O-])[O-].[Na+].[Na+],,val
US20030130305A1,C1=Cc2ccccc2OC1>>c1ccc2c(c1)CCCO2,[Pd],CC(=O)O,,,,val
US20070049555A1,BrP(Br)Br.O=c1[nH]c2c(c3ccccc13)Cc1c(CO)cccc1-2>>O=c1[nH]c2c(c3ccccc13)Cc1c(CBr)cccc1-2,,C1CCOC1,,,,val
US20040259875A1,Nc1cccc2ccc(O)cc12.O=Cc1ccccc1>>Oc1ccc2cccc(/N=C/c3ccccc3)c2c1,,C1CCOC1,,O=S(=O)([O-])[O-].[Na+].[Na+],,val
US20070232603A1,CC(C)(C)OC(=O)NCCN.COc1ccc([N+](=O)[O-])c(F)c1>>COc1ccc([N+](=O)[O-])c(NCCNC(=O)OC(C)(C)C)c1,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20030045560A1,BrBr.CCCCc1oc2ccccc2c1C(=O)NCc1ccc2cc(O)ccc2c1>>CCCCc1oc2ccccc2c1C(=O)NCc1ccc2c(Br)c(O)ccc2c1,,CC(=O)O,,,,val
US20130267546A1,CCCCCCCCCBr.COc1cc(C)nc(N(C)C)n1>>CCCCCCCCCCc1cc(OC)nc(N(C)C)n1,,C1CCOC1,,[Li]CCCC,,val
US20050054819A1,BrCc1ccccc1.CCOC(=O)C1CCC1>>CCOC(=O)C1(Cc2ccccc2)CCC1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20120295884A1,COC(=O)c1cc(Cl)c(F)c(CNC(=O)OC(C)(C)C)c1>>COC(=O)c1cc(Cl)c(F)c(CN)c1,,ClCCl,,CO,O=C(O)C(F)(F)F,val
US20110046132A1,CCOC(=O)c1cnn(-c2nc3cc(SCc4ccccc4)c(Cl)cc3n2COCCOC)c1>>CCOC(=O)c1cnn(-c2nc3cc(SCc4ccccc4)c(Cl)cc3[nH]2)c1,,CCO,,C1COCCO1,Cl,val
US04181802,CC(=O)c1cc(C)ccc1O.ClCC1CO1>>CC(=O)c1cc(C)ccc1OCC1CO1,,CO,,C[O-].[Na+],,val
US04846882,O=C1C2=C(CCCC2)C(=O)N1c1cc(CBr)c(Cl)cc1F.Oc1ccccc1>>O=C1C2=C(CCCC2)C(=O)N1c1cc(COc2ccccc2)c(Cl)cc1F,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04686292,COC(=O)c1cc(N)c([N+](=O)[O-])cc1OC.N>>COc1cc([N+](=O)[O-])c(N)cc1C(N)=O,,C1COCCO1,,O,,val
US20160257657A1,Cc1ccccc1N1CCNCC1.O=S(=O)(Cl)CCl>>Cc1ccccc1N1CCN(S(=O)(=O)CCl)CC1,,ClCCl,,CCN(CC)CC,,val
US20040067877A1,N[C@H](CCC(=O)O)C(=O)O>>O=C1CC[C@H](C(=O)O)O1,,Cl,O,O=N[O-].[Na+],,val
US20130345190A1,C#CCNC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C.O=C1N2C[C@@H](CC[C@H]2C(Cl)=NO)N1OCc1ccccc1>>CC(C)(C)OC(=O)N=C(NCc1cc([C@@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)no1)NC(=O)OC(C)(C)C,,ClCCl,,,,val
US20140315879A1,CC(C)Oc1ncc(COc2cc(F)c(C(=O)O)cc2F)cc1Cl.CN(C)S(N)(=O)=O>>CC(C)Oc1ncc(COc2cc(F)c(C(=O)NS(=O)(=O)N(C)C)cc2F)cc1Cl,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20060166990A1,Cc1cc(F)ccc1Nc1ccc(C(=O)c2cc(O)ccc2C)c([N+](=O)[O-])c1.OCCCCl>>Cc1cc(F)ccc1Nc1ccc(C(=O)c2cc(OCCCO)ccc2C)c([N+](=O)[O-])c1,,CC#N,,[I-].[K+],O=C([O-])O.[Na+],val
US20130146851A1,CCCC(C)n1ccc2c(S(C)=O)c(OS(=O)(=O)C(F)(F)F)ccc21.OB(O)c1cc2ccccc2s1>>CCCC(C)n1ccc2c(S(C)=O)c(-c3cc4ccccc4s3)ccc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[K+].[K+],,val
US20120068170A1,CC1(C)c2ccccc2-c2cc3c(cc21)[nH]c1ccccc13.Clc1nc(-c2cccc(-c3ccccc3)c2)nc(-c2cccc(-c3ccccc3)c2)n1>>CC1(C)c2ccccc2-c2cc3c4ccccc4n(-c4nc(-c5cccc(-c6ccccc6)c5)nc(-c5cccc(-c6ccccc6)c5)n4)c3cc21,,C1CCOC1,CN(C)C=O,[H-].[Na+],,val
US20100048651A1,CC(C)C(=O)OCCCl.COC(=O)/C=C/C(=O)O>>COC(=O)/C=C/C(=O)OCCOC(=O)C(C)C,,CN1CCCC1=O,,,,val
US20110218192A1,O=C1CC(c2ccccc2)Oc2cc(F)c(Br)cc21.OB(O)c1cccnc1F>>O=C1CC(c2ccccc2)Oc2cc(F)c(-c3cccnc3F)cc21,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCO,Cc1ccccc1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,O=C([O-])[O-].[Na+].[Na+],val
US20040209879A1,Cc1ccc(S(=O)(=O)Cl)cc1.O=C(CCCN1CCCC(CO)C1)c1ccc(F)cc1>>O=C(CCCN1CCCC(COS(=O)(=O)c2ccccc2)C1)c1ccc(F)cc1,,ClCCl,,CCN(CC)CC,,val
US20110152258A1,CCc1ccc(S(=O)(=O)Nc2ccc(F)cc2F)cc1.CN(C)C=O>>CCc1ccc(S(=O)(=O)Nc2ccc(F)c(C=O)c2F)cc1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20040157886A1,Fc1cccc(CC2CCNCC2)c1.O=C(O)C(=O)Nc1ccc2[nH]c(=O)oc2c1>>O=C(Nc1ccc2[nH]c(=O)oc2c1)C(=O)N1CCC(Cc2cccc(F)c2)CC1,,CCOCC,,,,val
US04414226,COC(=O)c1c(Cl)c(C)cc(OC)c1C1=C(O)C(=O)c2c(O)cccc2C1=O>>COc1cc(C)c(Cl)c2c(=O)oc3c(c12)C(=O)c1cccc(O)c1C3=O,,[Na+],[OH-],,,val
US20120101051A1,BrP(Br)Br.OCc1cc(C2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)ccc1Cl>>Clc1ccc(C2O[C@@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)cc1CBr,,CCOC(C)=O,CCOCC,c1ccncc1,,val
US20020173659A1,CCOC(=O)/C=C/c1cc2cc(Cl)c(Cl)cc2[nH]1>>OC/C=C/c1cc2cc(Cl)c(Cl)cc2[nH]1,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US04235666,O=C1c2ccccc2C(=O)C2CC=CCC12>>O=C1c2ccccc2C(=O)C2CCCCC12,,Cc1ccccc1,,[H][H],,val
US20150266867A1,CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)N[C@@H]2C(=O)N[C@@H]2CNC[C@H](O)COCOCC[Si](C)(C)C)cs1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)N[C@@H]2C(=O)N[C@@H]2CN2C[C@@H](COCOCC[Si](C)(C)C)OC2=O)cs1,,ClCCl,,,,val
US20040054173A1,CN.CS(=O)(=O)c1nccc(-c2c(-c3ccc(F)cc3)ccn2C2CCN(Cc3ccccc3)CC2)n1>>CNc1nccc(-c2c(-c3ccc(F)cc3)ccn2C2CCN(Cc3ccccc3)CC2)n1,,C1CCOC1,,,,val
US20110312930A1,Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1ccc(OCCCl)cc1.OC1CCNCC1>>Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1ccc(OCCN2CCC(O)CC2)cc1,,CN(C)C=O,,,,val
US20090318436A1,CC1(C)OB(c2cnc(F)c(F)c2)OC1(C)C.Clc1ccc(Br)nc1>>Fc1cc(-c2ccc(Cl)cn2)cnc1F,,C1COCCO1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05378797,C=CC(=O)OCC.OCc1ccccc1>>O=C(O)CCOCc1ccccc1,,O,,[Na+].[OH-],,val
US20130303524A1,COc1ccc(CN2CCC(C)(C)S2(=O)=O)c(OC)c1>>CC1(C)CCNS1(=O)=O,,ClCCl,,O=C(O)C(F)(F)F,,val
US04935509,OC1Cc2ccccc2C1>>OC1CC2CCCCC2C1,[Rh],CO,,,,val
US05223526,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cn1cc(C(=O)Nc2ccccc2C2CCCCC2)c(C(F)F)n1>>Cn1cc(C(=S)Nc2ccccc2C2CCCCC2)c(C(F)F)n1,,Cc1ccccc1,,,,val
US20080267887A1,Cc1cccc(C)c1-c1cc(/C=C/N(C)C)c([N+](=O)[O-])cn1>>Cc1cccc(C)c1-c1cc2cc[nH]c2cn1,[Zn],CC(=O)O,,,,val
US20160126478A1,Brc1ccc2[nH]c3ccc(Br)cc3c2c1.C1COCCO1.COc1ccc(B(O)O)cc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COc1ccc(-c2ccc3[nH]c4ccc(-c5ccc(OC)cc5)cc4c3c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,O=C([O-])[O-].[K+].[K+],,val
US20080070937A1,COc1ccc(-c2cnc(N)nc2)cc1.COc1ccc(S(=O)(=O)Cl)cc1OC>>COc1ccc(-c2cnc(NS(=O)(=O)c3ccc(OC)c(OC)c3)nc2)cc1,,c1ccncc1,,,,val
US20140171438A1,C#CCNC(=O)OC(C)(C)C.O=[N+]([O-])c1ccc(F)c(Br)c1>>CC(C)(C)OC(=O)NCC#Cc1cc([N+](=O)[O-])ccc1F,[Cu]I,CC#N,CCOC(C)=O,CCN(CC)CC,,val
US20080021038A1,C[C@H]1CC(C=O)CCO1.O=C(O)CC(=O)O>>C[C@H]1CC(/C=C/C(=O)O)CCO1,,c1ccncc1,,C1CCNCC1,,val
US20040048802A1,CC(C)(C)NS(=O)(=O)CCCCl>>CC(C)(C)NS(=O)(=O)C1CC1,,C1CCOC1,,[Li]CCCC,,val
US20150239847A1,NC1=NN(c2c(F)cccc2F)CC1.O=C(Cl)c1ccccc1Br>>O=C(NC1=NN(c2c(F)cccc2F)CC1)c1ccccc1Br,,ClCCl,,CCN(CC)CC,,val
US05576340,CC(=O)CBr.COC(=O)Cc1ccccc1O>>COC(=O)Cc1ccccc1OCC(C)=O,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04089861,CS(=O)(=O)O.Cc1ccc2c(c1)C[C@@H](N1CCN(CCN3CCOC3=O)CC1)c1cc(F)ccc1S2>>Cc1ccc2c(c1)CC(O)c1cc(F)ccc1S2,,c1ccccc1,,ClC(Cl)Cl,,val
US04431653,CCN1CCN=C1CCc1ccncc1>>CCN1CCN=C1CCC1CCNCC1,O=[Pt],CCO,O,Cl,,val
US20110130412A1,C=O.CC1(C)OC[C@@H](O)[C@H](N)CO1.O=c1[nH]cnc2cc[nH]c12>>O=c1[nH]cnc2c(CNC(CO)C(O)CO)c[nH]c12,,O,,,,val
US06593335B1,BrCc1ccc2nsnc2c1.O>>OCc1ccc2nsnc2c1,,C1COCCO1,O,O=C([O-])[O-].[Ca+2],,val
US20160007607A1,CI.O=c1[nH]c(C(=NOCc2nc(Br)cs2)c2ccccc2)no1>>Cn1c(C(=NOCc2nc(Br)cs2)c2ccccc2)noc1=O,,CC#N,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20040142850A1,CCOC(=O)N(Cc1cccc(C(F)(F)F)c1)c1c(N)cc(Br)cc1C(F)(F)F>>O=c1[nH]c2cc(Br)cc(C(F)(F)F)c2n1Cc1cccc(C(F)(F)F)c1,,CCO,,Cl,[H-].[Na+],val
US20060074075A1,BrCc1ccccc1.CC(C)(C)c1cc(Br)c([N+](=O)[O-])cc1O>>CC(C)(C)c1cc(Br)c([N+](=O)[O-])cc1OCc1ccccc1,,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20080269210A1,CC1(C)OB(c2ccc(N)nc2)OC1(C)C.CNCc1sc2c(N3CCOCC3)nc(Cl)nc2c1C.CS(=O)(=O)Cl>>Cc1c(CN(C)S(C)(=O)=O)sc2c(N3CCOCC3)nc(-c3ccc(N)nc3)nc12,,ClCCl,,CCN(CC)CC,,val
US05101048,O=[N+]([O-])c1ccc(S[C@@H]2SC[C@@H](O)[C@H](O)[C@H]2O)cc1>>Nc1ccc(S[C@@H]2SC[C@@H](O)[C@H](O)[C@H]2O)cc1,[Pd],CO,,,,val
US20150210646A1,COC(=O)/C=C/C[C@@]12CCN(CC3CC3)C(Cc3ccc(OC)cc31)[C@@H]2C>>COc1ccc2c(c1)[C@@]1(CCCCO)CCN(CC3CC3)C(C2)[C@@H]1C,,CCOCC,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US04873255,C=CC(=O)OCC.Cc1c(C)c(C)c2c(c1C)CCC(C)(COc1ccc(N)cc1)O2.Cl>>CCOC(=O)C(Cl)Cc1ccc(OCC2(C)CCc3c(C)c(C)c(C)c(C)c3O2)cc1,,CC(C)=O,O,O=N[O-].[Na+],,val
US20090215759A1,COc1cc([N+](=O)[O-])ccc1-c1cncs1>>COc1cc(N)ccc1-c1cncs1,,CCO,,,,val
US20150210701A1,CC(C)(C)OC(=O)N1C[C@H](CCSCCOCCO)[C@@H](O)C1>>OCCOCCSCC[C@H]1CNC[C@@H]1O,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20160009667A1,N#Cc1cc(Cl)c(F)cc1F.OCC1CCCCC1>>N#Cc1cc(Cl)c(OCC2CCCCC2)cc1F,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US06339160B1,CC(C)C[C@H](NC(=O)[C@@H]1CCC(=O)O1)C(=O)OC(C)(C)C>>CC(C)C[C@H](NC(=O)[C@@H]1CCC(=O)O1)C(=O)O,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130303492A1,CSC(SC)=C(C#N)C(N)=O.Nc1ccc(Cl)c(Cl)c1>>CSC(Nc1ccc(Cl)c(Cl)c1)=C(C#N)C(N)=O,,CCO,,,,val
US20150307489A1,CCOC(=O)C#Cc1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(OC)cn1.CNN>>COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)[nH]n2C)nc1,,C1CCOC1,,,,val
US05231101,N#Cc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C(=O)OCC(Cl)(Cl)Cl)CC1>>N#Cc1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1,[Zn],CC(=O)O,,[Na+].[OH-],,val
US20060178399A1,CS(=O)(=O)Nc1ccc(Oc2ccc(C=O)cc2)cc1.ClCCNCCCl>>CS(=O)(=O)Nc1ccc(Oc2ccc(CN(CCCl)CCCl)cc2)cc1,,CN(C)C=O,O,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040019098A1,C1COCCN1.CN(CCCl)c1ccc2c(c1)COC2=C1C(=O)Nc2ccccc21>>CN(CCN1CCOCC1)c1ccc2c(c1)COC2=C1C(=O)Nc2ccccc21,,CN(C)C=O,,O,,val
US20100261755A1,CC1(C)OB(c2cc(Cl)cc(Cl)c2)OC1(C)C.COC(=O)c1ccnc(Cl)c1>>COC(=O)c1ccnc(-c2cc(Cl)cc(Cl)c2)c1,Cl[Pd]Cl,ClCCl,O,CO,O=C([O-])[O-].[K+].[K+],val
US20100144707A1,COc1cccc(-c2nc3ccccc3c(=O)[nH]2)c1>>O=c1[nH]c(-c2cccc(O)c2)nc2ccccc12,,ClCCl,,BrB(Br)Br,,val
US20050096306A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cn1ncc(NC(=O)/C(=C/C#N)CCNC(=O)OC(C)(C)C)c1NC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cn1ncc(NC(=O)C(CCNC(=O)OC(C)(C)C)CCNC(=O)OC(C)(C)C)c1NC(c1ccccc1)(c1ccccc1)c1ccccc1,O=[Pt]=O,C1CCOC1,,,,val
US20150284362A1,CNC(C)CCN.O=C(n1ccnc1)n1ccnc1>>CC1CCNC(=O)N1C,,C1CCOC1,,,,val
US04447360,C=C(C)C(C(=O)OC)N1C(=O)C[C@H]1SSc1nc2ccccc2s1>>COC(=O)C(=C(C)C)N1C(=O)C[C@H]1SSc1nc2ccccc2s1,,ClCCl,,CCN(CC)CC,,val
US04966623,CCO.NC(=O)c1c(C(=O)O)cnn1-c1cc(Cl)cc(Cl)c1>>CCOC(=O)c1cnn(-c2cc(Cl)cc(Cl)c2)c1C(N)=O,,Cl,,,,val
US05182404,NC(=O)C1=CCC23OCOC2=C1c1c(cccc1C(N)=O)OCO3>>N#Cc1ccc2c(c1-c1c(C#N)ccc3c1OCO3)OCO2,,O=P(Cl)(Cl)Cl,,,,val
US20050209241A1,CNS(=O)(=O)c1ccc(O)c(C(=O)OC)c1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CNS(=O)(=O)c1ccc(OCC(F)(F)F)c(C(=O)OC)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20110178132A1,N#Cc1cc(-c2ccc(Cl)cc2C(F)(F)F)ccn1.NO>>NC(=NO)c1cc(-c2ccc(Cl)cc2C(F)(F)F)ccn1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20090062333A1,CC(C)(C)Oc1c(Br)cccc1C#N.O=S(=O)(OC1=CC2CCC(C1)N2Cc1ccccc1)C(F)(F)F>>CC(C)(C)Oc1c(C#N)cccc1C1=CC2CCC(C1)N2Cc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,CC(C)[Mg]Cl,,val
US20090221583A1,O=C(NCC(=O)N1CCN(C(=O)Cc2ccccc2)CC1)c1ccc(OCc2ccccc2)cc1>>O=C(NCC(=O)N1CCN(C(=O)Cc2ccccc2)CC1)c1ccc(O)cc1,[Pd],CO,,O=C[O-].[NH4+],,val
US20040138449A1,C1COCCN1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2sc(CCl)cc21>>Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2sc(CN3CCOCC3)cc21,,CN(C)C=O,O,CCN(C(C)C)C(C)C,,val
US20090023710A1,NCc1ccccc1Oc1ccc(Cl)cc1.O=C1CCN(C(=O)C2CCCC2)CC1>>O=C(C1CCCC1)N1CCC(NCc2ccccc2Oc2ccc(Cl)cc2)CC1,,ClCCCl,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040209865A1,OB(O)Oc1ccc(Cl)cc1.OCCn1ccc2cc(C#Cc3ccc(Br)cn3)ccc21>>OCCn1ccc2cc(C#Cc3ccc(-c4ccc(Cl)cc4)cn3)ccc21,,C1COCCO1,CO,O=C([O-])[O-].[Na+].[Na+],,val
US05096908,C1CCNC1.O=C1CCc2cccc(Br)c2C1>>Brc1cccc2c1CCC(N1CCCC1)=C2,,Cc1ccccc1,,,,val
US20160264567A1,C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)s3)ncc2Cl)N1C(=O)OC(C)(C)C.Cl>>C[C@@H]1N[C@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)s3)ncc2Cl)C[C@H]1F.Cl,,C1COCCO1,,,,val
US20110118283A1,CC(C)(C)C/C=N/CC(=O)OC(C)(C)C.N#C/C(=C\c1cccc(Cl)c1)c1cccnc1>>CC(C)(C)CC1NC(C(=O)OC(C)(C)C)C(c2cccc(Cl)c2)C1(C#N)c1cccnc1,,ClCCCl,,CCN(CC)CC,,val
US04889851,CCOC(=O)CBr.CN1C(=O)N(c2ccc(Cl)cc2)S(=O)(=O)c2ccc(O)cc21>>CN1C(=O)N(c2ccc(Cl)cc2)S(=O)(=O)c2ccc(OCC(=O)O)cc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20130029990A1,COCC(=O)Nc1cc(Oc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)ccn1>>COCC(=O)Nc1cc(Oc2ccc(N)c(C(F)(F)F)c2)ccn1,[Pt],CC(=O)O,CO,[H][H],,val
US05840732,CCCCCC=C1OC(=O)N(CCCCOc2cccn3ccnc23)C1=O.Cl>>CCCCCC=C1OC(=O)N(CCCCOc2cccn3ccnc23)C1=O.Cl,,CO,,CCOC(C)=O,,val
US05158971,C[Si](C)(C)N=C=O.ONCCc1ccc(Sc2cccc(C(F)(F)F)c2)s1>>NC(=O)N(O)CCc1ccc(Sc2cccc(C(F)(F)F)c2)s1,,C1COCCO1,,,,val
US05281571,CCOC(=O)CBr.Cn1nc(-c2cc(O)c(Cl)cc2F)c(Cl)c1C(F)(F)F>>CCOC(=O)COc1cc(-c2nn(C)c(C(F)(F)F)c2Cl)c(F)cc1Cl,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100160430A1,COC(=O)CS(=O)(=O)CCC(F)(F)F.COC(CCOS(=O)(=O)c1ccc(C)cc1)C(F)(F)F>>COC(=O)C(CCC(OC)C(F)(F)F)S(=O)(=O)CCC(F)(F)F,,CS(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US04398029,CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)c(F)c21.OC1CCCNC1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCCC(O)C3)c(F)c21,,c1ccncc1,,,,val
US20110245315A1,COC(=O)c1ccc2c(c1)CCN2S(=O)(=O)c1ccccc1>>O=C(O)c1ccc2c(c1)CCN2S(=O)(=O)c1ccccc1,,C1COCCO1,,[Li+].[OH-],,val
US05430042,Cc1occc(=O)c1O.OCCCBr>>Cc1occc(=O)c1OCCCO,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150111734A1,CCN(C(=O)CCNCC(F)F)c1cn(-c2cccnc2)nc1Cl.O=C(O)C1CC1(F)F>>CCN(C(=O)CCN(CC(F)F)C(=O)C1CC1(F)F)c1cn(-c2cccnc2)nc1Cl,CN(C)c1ccncc1,ClCCl,,,,val
US05792769,CC(C)(C)OC(=O)N1CCN(CCOc2cccc(OS(=O)(=O)c3ccccc3Cl)c2)CC1>>O=S(=O)(Oc1cccc(OCCN2CCNCC2)c1)c1ccccc1Cl,,Cl,,,,val
US20020091272A1,CC(=O)OCc1c(C)cc(C)c([N+](=O)[O-])c1C>>CC(=O)OCc1c(C)cc(C)c(N)c1C,[Zn],CO,,[Cl-].[NH4+],,val
US20010027196A1,CS(=O)c1nc(N)nc(-c2ccco2)c1Br.NCc1ccccc1>>Nc1nc(NCc2ccccc2)c(Br)c(-c2ccco2)n1,,C1COCCO1,,,,val
US20070045613A1,CCCCCCCCc1cccs1.O=C1CCC(=O)N1Br>>CCCCCCCCc1ccc(Br)s1,,CN(C)C=O,,O,,val
US20090111864A1,COC(=O)CCCc1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C23CCC3)cc1>>N#Cc1ccc(N2C(=O)C3(CCC3)N(c3ccc(CCCC(=O)O)cc3)C2=S)cc1C(F)(F)F,,CO,,[Na+].[OH-],,val
US20040259910A1,CC(=O)OC(C)=O.CCOc1cccc(C(=O)c2ncc(C=O)c3cc(OCCCO)c(OC)cc23)c1>>CCOc1cccc(C(=O)c2ncc(C=O)c3cc(OCCCOC(C)=O)c(OC)cc23)c1,,c1ccncc1,,,,val
US20080004309A1,CCOC(=O)CNCc1ccc(OC)cc1OC.CCOC(=O)c1sc(C(C)(C)C)nc1CBr>>CCOC(=O)CN(Cc1ccc(OC)cc1OC)Cc1nc(C(C)(C)C)sc1C(=O)OCC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050272778A1,COC(=O)c1c(OC)cccc1Oc1ccc(COCc2ccc(C3=CC(=O)NS3(=O)=O)cc2)cc1>>COC(=O)c1c(OC)cccc1Oc1ccc(COCc2ccc(C3CC(=O)NS3(=O)=O)cc2)cc1,,C1CCOC1,,[BH4-].[Li+],,val
US20150299169A1,CC1(C)Cc2nc(C3CCN(c4ncc(OCC(C)(CO)CO)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1.CS(=O)(=O)O>>CC1(C)Cc2nc(C3CCN(c4ncc(OCC(C)(CO)CO)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](OS(C)(=O)=O)C1,,COC(C)(C)C,,,,val
US20050215797A1,Cc1c(C(F)(F)F)nn(C(C)C)c1O.FC(F)Cl>>Cc1c(C(F)(F)F)nn(C(C)C)c1OC(F)F,,CC(C)O,,O,[K+].[OH-],val
US20140275026A1,COc1nccc2c(-c3cc([N+](=O)[O-])ccc3F)cn(C)c12.Oc1ccc(F)cc1F>>COc1nccc2c(-c3cc([N+](=O)[O-])ccc3Oc3ccc(F)cc3F)cn(C)c12,,CS(C)=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100267943A1,C=CC/C(C)=C\C[C@H](O)C(=O)N(C)OC.CC(C)(C)[Si](C)(C)Cl>>C=CC/C(C)=C\C[C@H](O[Si](C)(C)C(C)(C)C)C(=O)N(C)OC,,CCOC(C)=O,CCOCC,CN(C)C=O,c1c[nH]cn1,val
US04378314,CC(=O)OC=O.O=C1NC(SC(c2ccccc2)(c2ccccc2)c2ccccc2)C1CO>>O=COC[C@@H]1C(=O)N[C@H]1SC(c1ccccc1)(c1ccccc1)c1ccccc1,,ClCCl,,CCN(CC)CC,,val
US04609650,CC(O)C(=O)[O-].CC[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]2(C)[C@H]1OC(=O)CBr>>CC[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]2(C)[C@H]1OC(=O)COC(=O)C(C)O,,CN(C)C=O,,CCOC(C)=O,O,val
US05444080,CCCCc1ncc(CCC(=O)OCC)n1COCC[Si](C)(C)C>>CCCCc1nc(CCC(=O)OCC)c[nH]1,,CCO,,Cl,,val
US04022777,CCOC(=O)CBr.CCc1nc2nc3cc(Cl)ccc3nc2[nH]1>>CCOC(=O)Cn1c(CC)nc2nc3cc(Cl)ccc3nc21,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20100144705A1,CC1(C)OB(c2ccc(O)c(F)c2)OC1(C)C.ClCc1ccccn1>>CC1(C)OB(c2ccc(OCc3ccccn3)c(F)c2)OC1(C)C,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20130190332A1,COc1ccnc(N)n1.O=C1NC2(c3ccc(C(=O)C(Br)c4ccccc4)cc3)CC(C2)O1>>COc1ccn2c(-c3ccccc3)c(-c3ccc(C45CC(C4)OC(=O)N5)cc3)nc2n1,,CCO,,CCN(CC)CC,,val
US20130210802A1,Cc1cc([N+](=O)[O-])nn1CCO>>Cc1cc(N)nn1CCO,[Pd],CCO,,,,val
US20050075348A1,CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC=O.Cc1[nH]c2ccc(CCN)cc2c1C(=O)OCc1ccccc1.Cl.ClCCl>>CCN(CC)CCc1ccc2[nH]c(C)c(C(=O)OCc3ccccc3)c2c1.Cl.Cl,,ClCCl,,O=C([O-])O.[Na+],,val
US20070293492A1,Cc1ccc2c(-c3ccccc3)c(NC(=O)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)ccc2n1>>Cc1ccc2c(-c3ccccc3)c(NCCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)ccc2n1,,C1CCOC1,,,,val
US20080293771A1,CC(C)(C)OC(=O)N1CC[C@@H](N)C1.O=C(O)c1ccc(-n2ncc3ccccc32)cc1>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)c2ccc(-n3ncc4ccccc43)cc2)C1,,CO,,,,val
US03931151,CCOC(=O)CC1(O)Cc2ccccc2N(C)c2ccc(SCC)cc21>>CCOC(=O)C=C1Cc2ccccc2N(C)c2ccc(SCC)cc21,,CCO,,Cl,,val
US04892870,CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O.CC(C)N1OCCC(Br)C1=O>>CC(C)N1OCCC(C(O)c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)C1=O,[Zn],c1ccccc1,,,,val
US20050234083A1,CN(c1ccc2c(c1)nc(N(C(=O)OC(C)(C)C)c1ccccc1)n2C)c1ccnc(Nc2cccc(S(N)(=O)=O)c2)n1.O=C(O)C(F)(F)F>>CN(c1ccc2c(c1)nc(Nc1ccccc1)n2C)c1ccnc(Nc2cccc(S(N)(=O)=O)c2)n1.O=C(O)C(F)(F)F,,ClCCl,,Cl,,val
US20150045368A1,CC1(C)OC(=O)N[C@H]1c1ccccc1.COC(=O)c1ccc(Br)cc1C>>COC(=O)c1ccc(N2C(=O)OC(C)(C)[C@@H]2c2ccccc2)cc1C,[Cu]I,C1COCCO1,,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US05225402,O.O=C(c1ccc(OCCCCC2CO2)cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1>>O=C(c1ccc(OCCCCC(O)CO)cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1,,C1COCCO1,O,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US04853408,CC(C)(C)NCCOc1ccccc1CCCc1cccc2[nH]cc(Cl)c12.O>>CC(C)(C)NCCOc1ccccc1CCCc1cccc2c1CC(=O)N2,,CCO,O,Cl,[Na+].[OH-],val
US20060040989A1,CCOC(=O)CC1CCNCC1.O=[N+]([O-])c1ccc(F)cc1>>CCOC(=O)CC1CCN(c2ccc([N+](=O)[O-])cc2)CC1,,CS(C)=O,,O=C([O-])[O-].[Na+].[Na+],,val
US20040204427A1,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.COC(=O)[C@H](C)CO>>COC(=O)[C@H](C)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C,,ClCCl,,c1c[nH]cn1,,val
US20140038999A1,CC(C)C[C@@H](COc1ccc2c3ccncc3c(=O)n(C)c2c1)NC(=O)OC(C)(C)C>>CC(C)C[C@H](N)COc1ccc2c3ccncc3c(=O)n(C)c2c1,,C1COCCO1,ClCCl,Cl,,val
US05334720,CN(C)CCCCl.O=C1CCC(c2ccccc2)(c2ccccc2)CN1>>CN(C)CCCN1CC(c2ccccc2)(c2ccccc2)CCC1=O.Cl,,CS(C)=O,,[K+].[OH-],,val
US05981557,CN(C)CCO.COc1cc(OC)c(C(=O)Nc2nc(C(=O)O)cs2)cc1OC>>COc1cc(OC)c(C(=O)Nc2nc(C(=O)OCCN(C)C)cs2)cc1OC,,CN(C)C=O,,[H-].[Na+],,val
US20040142999A1,CCC[C@H](NC(=O)[C@@H](N)CS(=O)(=O)CC1CC1)C(O)c1nc2ccccc2o1.O=C1CCOCC1>>CCC[C@H](NC(=O)[C@H](CS(=O)(=O)CC1CC1)NC1CCOCC1)C(O)c1nc2ccccc2o1,,CC#N,CC(=O)O,,,val
US20050239826A1,Cc1cc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)ccc1OCCOS(C)(=O)=O.NC1CCCC1>>Cc1cc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)ccc1OCCNC1CCCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20100004238A1,CC(C)(C)OC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4ccc5ccsc5c4)c(Cl)c3)c21.CCOC(C)=O.Cl>>CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4ccc5ccsc5c4)c(Cl)c3)c21.Cl,,CCO,,Cl,,val
US20100249139A1,CI.COc1ccc(Cl)c(CC(=O)c2ccc(=O)n(C)c2)c1>>COc1ccc(Cl)c(C(C)C(=O)c2ccc(=O)n(C)c2)c1,,C1CCOC1,,CCOC(C)=O,[H-].[Na+],val
US20060235030A1,CC(C)O.Cc1ccc(C(=O)Nc2ccc(C)c(-c3nc(S(C)(=O)=O)nc4c3CNC(=O)N4c3c(F)cccc3F)c2)cc1F>>Cc1ccc(C(=O)Nc2ccc(C)c(-c3nc(OC(C)C)nc4c3CNC(=O)N4c3c(F)cccc3F)c2)cc1F,,CCOC(C)=O,,[H-].[Na+],,val
US04680301,CC(C)(C)c1nc2cc(N3CCOCC3)c([N+](=O)[O-])cc2s1>>CC(C)(C)c1nc2cc(N3CCOCC3)c(N)cc2s1,[Ni],CO,,,,val
US20080275018A1,CN1C(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)Cc2cc(ccc2O)-c2cccc(c2)C[C@H]1C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)NCCC[C@@H](CC(=O)NCCNC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1>>CN1C(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)Cc2cc(ccc2O)-c2cccc(c2)C[C@H]1C(=O)N[C@@H](CCCN)C(=O)NCCC[C@H](N)CC(=O)NCCN,[Pd],CC(=O)O,O,[H][H],,val
US20130225589A1,N#CCCl.O=C(O)c1cccnc1Nc1ccccc1>>COC(=O)c1cccnc1Nc1ccccc1,,CC(C)=O,,CCN(CC)CC,,val
US03976635,CCOC(=O)ON=C(C#N)C(N)=O.O=C(O)c1ccccc1>>CCOC(=O)c1ccccc1,,C1CCOC1,,CCN(CC)CC,O,val
US20050187272A1,COC(=O)CCc1cc(C(C)C)c(O)c(C(C)C)c1>>CC(C)c1cc(CCC(=O)O)cc(C(C)C)c1O,,CCCCCCC,CCOC(C)=O,C1CCOC1,O,val
US20130143907A1,COc1nc(C)cc(C)c1-c1ccc(-c2c(C(N)=O)cnn2C2CCOCC2)c(F)c1>>COc1nc(C)cc(C)c1-c1ccc2c(c1)[nH]c(=O)c1cnn(C3CCOCC3)c12,,CN1CCCC1=O,,O,,val
US20100056811A1,COc1ccc(C(C)=O)cc1.C[Mg]Cl>>COc1ccc(C(C)(C)O)cc1,,C1CCOC1,,O,,val
US20120101051A1,Cc1cnc(-c2ccc(Cc3cc([C@@H]4O[C@H](COCc5ccccc5)[C@@H](OCc5ccccc5)[C@H](OCc5ccccc5)[C@H]4OCc4ccccc4)ccc3Cl)nn2)o1>>Cc1cnc(-c2ccc(Cc3cc([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)ccc3Cl)nn2)o1,,CC#N,,C[Si](C)(C)I,,val
US20090028787A1,CNc1ncc(Br)cn1.COc1ccc2ncsc2c1.COc1ncc(-c2nc3ccccc3s2)cn1>>CNc1ccc(-c2nc3cc(OC)ccc3s2)cn1,,O,,CCOC(C)=O,,val
US20070197797A1,O=C1CCCc2[nH]c3c(c21)CCCC3>>Oc1cccc2[nH]c3ccccc3c12,[Ni],O,,[K+].[OH-],,val
US20090137561A1,COC(=O)c1ccc(O)c(CC(C)C)c1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1ccc(OS(=O)(=O)C(F)(F)F)c(CC(C)C)c1,CN(C)c1ccncc1,,,ClCCl,,val
US20110098296A1,CCOC(=O)c1cccc(N)c1.O=C(Cl)c1cc(F)ccc1F>>CCOC(=O)c1cccc(NC(=O)c2cc(F)ccc2F)c1,,ClCCl,,,,val
US05155100,BrP(Br)Br.OCc1ccc(-c2ccccc2)cc1>>BrCc1ccc(-c2ccccc2)cc1,,CCCCCC,CCOC(C)=O,ClCCl,O,val
US20150057271A1,COc1cc(C(F)(F)F)ccc1Nc1ccc([N+](=O)[O-])cc1O.O=C(Cl)CCl>>COc1cc(C(F)(F)F)ccc1N1C(=O)COc2cc([N+](=O)[O-])ccc21,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20110021520A1,Brc1cccc(I)c1.CCOC(=O)/C(=N\C(=O)OC(C)(C)C)C(F)(F)F>>CCOC(=O)C(NC(=O)OC(C)(C)C)(c1cccc(Br)c1)C(F)(F)F,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20140296584A1,CO.O=C1CCc2ccccc2C1>>COc1ccc2c(c1)CC(O)CC2,,CO,,CCN(CC)CC,O=CO,val
US05114961,CCCOc1c(OCc2ccccc2)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O>>CCCOc1c(O)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O,CC(=O)O,CCOC(C)=O,,,,val
US06582351B1,COc1ccc(Cn2c(=O)n(C3COC(C)(C)OC3)c3ccc(C#N)cc32)cc1OC>>COc1ccc(Cn2c(=O)n(C(CO)CO)c3ccc(C#N)cc32)cc1OC,,C1CCOC1,,Cl,,val
US20050197338A1,Cc1cc(-n2cc(NC(N)=O)c(C(N)=O)n2)ccc1I.OB(O)c1cccc(O)c1>>Cc1cc(-n2cc(NC(N)=O)c(C(N)=O)n2)ccc1-c1cccc(O)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060287298A1,COC(=O)C1CCCCN1CCC(O)(c1ccc(F)cc1)c1ccc(Cl)cc1>>COC(=O)C1CCCCN1CC=C(c1ccc(F)cc1)c1ccc(Cl)cc1,,O=CO,,,,val
US07723065B2,C/C(=C/c1ccccc1)[N+](=O)[O-]>>CC(Cc1ccccc1)[N+](=O)[O-],,O,,,,val
US06518257B1,CC(C)C(O)(c1cccc(Br)c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.OB(O)c1ccc(F)cc1F>>CC(C)C(O)(c1cccc(-c2ccc(F)cc2F)c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,O=C([O-])[O-].[Na+].[Na+],,val
US05591850,CCCCC(CC)CBr.Oc1ccc(Br)cc1>>CCCCC(CC)COc1ccc(Br)cc1,,COCCO,,[Na+].[OH-],,val
US20060020003A1,BrBr.COc1ccc(-c2ccc(C=O)cc2)cc1>>COc1ccc(-c2ccc(C=O)cc2)cc1Br,,CC(=O)O,,,,val
US06004724,N#CCc1ccccc1.O=[N+]([O-])c1ccccc1>>N#CC(=C1C=CC(=NO)C=C1)c1ccccc1,,CO,O,CC(=O)O,[K+].[OH-],val
US05597845,CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(CC=O)C(=O)OC(C)(C)C>>CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(CCO)C(=O)OC(C)(C)C,,CCO,CCOC(C)=O,[BH4-].[Na+],,val
US20090156607A1,CCCC1CC(=O)N(Cc2cnn3ccc(Cl)nc23)C1.CO>>CCCC1CC(=O)N(Cc2cnn3ccc(OC)nc23)C1,,CO,,C[O-].[Na+],,val
US20160251380A1,CC(C)(C)OC(=O)NCC1C=C2C=COCC3=C2B(O1)OC3(C)C.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)NC[C@@H]1OB2OC(C)(C)C3=C2C(=C1Br)C=COC3,,CC(Cl)Cl,,,,val
US20110059943A1,CC(=O)N=C=S.CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(N)nc21>>CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(NC(=S)NC(C)=O)nc21,,CC(C)=O,,,,val
US20080207654A1,CCCc1nc(C)n(-c2ccc(SC(C)C)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.O=C([O-])O.[NH3+]O>>CCCc1nc(C)n(-c2ccc(SC(C)C)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1,,CCOC(C)=O,O,CS(C)=O,[Cl-].[Na+],val
US20150031674A1,CC(C)(C)OC(=O)N1CCC2(CC1)CC(O)CO2.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OC2COC3(CCN(C(=O)OC(C)(C)C)C3)C2)cc1,CN(C)c1ccncc1,ClCCl,,,,val
US03948906,O=C(Cc1cccs1)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(=O)C(Cl)Cl)CS[C@H]12.c1ccncc1>>O=C(Cc1cccs1)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12,,O,,CC(=O)O,,val
US20050065340A1,N#CCc1ccc(-c2nc3ccccc3o2)cc1[N+](=O)[O-]>>N#CCc1ccc(-c2nc3ccccc3o2)cc1N,[Pd],CCO,CCOC(C)=O,,,val
US20080113980A1,CC(C)(C)OC(=O)N1CCCc2ccc(O)cc21.CI>>COc1ccc2c(c1)N(C(=O)OC(C)(C)C)CCC2,,CN(C)C=O,,[H-].[Na+],,val
US20070004717A1,C=C(OCC)OCC.O=C1C=CCC1>>CCOC1(OCC)CC2C(=O)CCC21,,CCCCC,,,,val
US09096550B2,C=C1CC(/C=C/C(C)(C)[C@]2(OC)O[C@H](C[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](C)OCOCc3ccccc3)CCC2=O)OC(CC2C[C@@H](O)CC(C[C@H](CCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)OCc3ccc(OC)cc3)O2)C1.CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F>>C=C1C[C@H](/C=C/C(C)(C)[C@]2(OC)O[C@H](C[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](C)OCOCc3ccccc3)CCC2=O)O[C@H](C[C@H]2C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H](C[C@H](CCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)OCc3ccc(OC)cc3)O2)C1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20020165227A1,CCC1(C)CN(Cc2ccccc2)CC(C)C1=O>>CCC1(C)CN(Cc2ccccc2)CC(C)C1O,,CO,,[BH4-].[Na+],,val
US20110053931A1,Cc1ccccc1Cc1ncnc(Cl)c1C.OCc1ccccc1>>Cc1ccccc1Cc1ncnc(OCc2ccccc2)c1C,C1COCCOCCOCCOCCOCCO1,Cc1ccccc1,,O,[K+].[OH-],val
US20080249093A1,CCOC(=O)CBr.COc1cc2c(cc1C)C(=O)CC2>>CCOC(=O)C=C1CCc2cc(OC)c(C)cc21,[Zn],C1CCOC1,,,,val
US04474754,CC(C)(C)OC(=O)NNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1,[Pd],CO,,,,val
US20100048636A1,COC(=O)[C@@H](CNC(=O)CCCCl)NC(=O)OCc1ccccc1>>O=C(CCCCl)NC[C@H](CO)NC(=O)OCc1ccccc1,,CO,,[BH4-].[Na+],,val
US20150051160A1,C=CCOC(=O)[C@H](Cc1ccc(OC(=O)Oc2ccc([N+](=O)[O-])cc2)cc1)NC(=O)OC(C)(C)C.CC(C)(C)OC(=O)NCC[C@H](N)C(=O)O>>C=CCOC(=O)[C@H](Cc1ccc(OC(=O)N[C@@H](CCNC(=O)OC(C)(C)C)C(=O)O)cc1)NC(=O)OC(C)(C)C,,ClCCl,,,,val
US20110306597A1,CC(C)(C)OC(=O)NCC1CCCNC1.N=C(N)n1cccn1>>CC(C)(C)OC(=O)NCC1CCCN(C(=N)N)C1,,CN(C)C=O,,CCN(C(C)C)C(C)C,Cl,val
US20110190258A1,Cc1cc([C@H](Nc2ccc(C)c(C=O)c2)C(F)(F)F)ccc1Cl.O=C(O)[C@@H]1CCNC1>>Cc1cc([C@H](Nc2ccc(C)c(CN3CC[C@@H](C(=O)O)C3)c2)C(F)(F)F)ccc1Cl,,CO,,CC(=O)O,,val
US20160096839A1,CC1(C)OB(c2c(C(F)F)ccc(Cl)c2F)OC1(C)C.COc1cc(Cl)ncn1>>COc1cc(-c2c(C(F)F)ccc(Cl)c2F)ncn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CCO,,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US06239131B1,Cc1ccc2c(c1)N(CC(=O)c1ccccc1C)C(=O)C(NC(=O)OC(C)(C)C)CN2C1CCCCC1>>Cc1ccc2c(c1)N(CC(=O)c1ccccc1C)C(=O)C(N)CN2C1CCCCC1,,C1COCCO1,Cl,,,val
US20090209607A1,CCn1ncc(Cl)c1-c1csc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)c1>>CCn1ncc(Cl)c1-c1csc(C(=O)N[C@H](CN)Cc2ccccc2C(F)(F)F)c1,,CO,,NN,,val
US20160151337A1,CN(C)C=O.Cc1sc(-c2cccnc2)nc1N1CCc2[nH]c(-c3c(F)cccc3F)cc2C1.O>>Cc1sc(-c2cccnc2)nc1N1CCc2[nH]c(-c3c(F)cccc3F)c(CO)c2C1,,CN(C)C=O,,O=P(Cl)(Cl)Cl,O=C([O-])O.[Na+],val
US20040077877A1,CCCC(=O)Cl.Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1>>CCCC(=O)Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1,,C1CCOC1,,CCN(CC)CC,,val
US06358574B1,C=CCOc1ccccc1C(=O)O[C@@H]1CC[C@@H](O)CC1.O=C(Cl)CCCCCBr>>C=CCOc1ccc(C(=O)O[C@@H]2CC[C@@H](C(=O)CCCCCBr)CC2)cc1,,Cc1ccccc1,,O=S(Cl)Cl,,val
US05521179,CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)OCc2ccccc2)c1=O)C(O[Si](C)(C)C(C)(C)C)C(F)(F)F>>CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)OCc2ccccc2)c1=O)C(O)C(F)(F)F,,C1CCOC1,CCOC(C)=O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US05338739,CN=C=O.Oc1cccc(C2CCCN2Cc2cccnc2)c1>>CNC(=O)Oc1cccc(C2CCCN2Cc2cccnc2)c1,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20110092479A1,COc1ccc(CCl)cc1.O=[N+]([O-])c1cnc2[nH]nc(I)c2c1>>COc1ccc(Cn2nc(I)c3cc([N+](=O)[O-])cnc32)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[Cs+].[Cs+],val
US20070281955A1,CC(=O)c1cccc(-c2nc3sccn3c2-c2ccnc(N[C@@H]3CCCN(S(=O)(=O)c4ccc(Cl)cc4)C3)n2)c1.NO>>C/C(=N\O)c1cccc(-c2nc3sccn3c2-c2ccnc(N[C@@H]3CCCN(S(=O)(=O)c4ccc(Cl)cc4)C3)n2)c1,,CO,ClCCl,CC(=O)O,Cl,val
US04859684,COC(OC)(OC)OC.Nc1ccc(C(c2ccccc2)n2ccnc2)cc1N>>COc1nc2cc(C(c3ccccc3)n3ccnc3)ccc2[nH]1,,ClCCl,,CC(=O)O,,val
US03935267,C=O.CC(C)NCC(O)COc1cccc2c1CCC(O)C2.Cl>>CC(C)N1COC(COc2cccc3c2CCC(O)C3)C1.Cl,,CCO,,,,val
US20100297077A1,COc1c(Cl)c(C)c(C(C)=O)c(OCCBr)c1OCCC(C)c1ccc(F)cc1.c1c[nH]cn1>>COc1c(Cl)c(C)c(C(C)=O)c(OCCn2ccnc2)c1OCCC(C)c1ccc(F)cc1,,ClCCl,,,,val
US20150119405A1,C=CC[C@H](C(=O)N1C(=O)OC[C@H]1Cc1ccccc1)[C@@H](O)/C=C/c1ccccc1.Cc1ccccc1>>O=C1CC[C@@H](Cc2ccccc2)N1C(=O)[C@H]1CC=C[C@@H]1O,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,,,,,val
US20060160864A1,CCCCOCCOc1ccc(-c2ccc(N3CCCC(C)C3)c(/C=C/C(=O)OCC)c2)cc1>>CCCCOCCOc1ccc(-c2ccc(N3CCCC(C)C3)c(/C=C/C(=O)O)c2)cc1,,C1CCOC1,CCO,Cl,[Na+].[OH-],val
US20090186884A1,CN(C[C@@H](O)[C@@H](N)CC1CCOCC1)C(=O)OCC[Si](C)(C)C.COC(=O)NCCO[C@@H](c1cccc(Cl)c1)[C@H]1CNCCO1.O=C(n1ccnc1)n1ccnc1>>COC(=O)NCCO[C@@H](c1cccc(Cl)c1)[C@H]1CN(C(=O)N[C@@H](CC2CCOCC2)[C@H](O)CN(C)C(=O)OCC[Si](C)(C)C)CCO1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100273786A1,CC(=O)c1nc(C(F)(F)F)n2c1CN(C(=O)C[C@@H](Cc1cc(F)c(F)cc1F)NC(=O)OC(C)(C)C)CC2.Cl>>CC(=O)c1nc(C(F)(F)F)n2c1CN(C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)CC2.Cl,,CCOC(C)=O,,,,val
US20160168090A1,CN1C(=O)CC[C@@H]1CO.O=C(NCC1CCC(F)(F)CC1)c1c[nH]c2cccc(Cl)c12>>CN1C(=O)CC[C@@H]1Cn1cc(C(=O)NCC2CCC(F)(F)CC2)c2c(Cl)cccc21,,Cc1ccccc1,,CCCCP(=CC#N)(CCCC)CCCC,,val
US06130239,C#C[C@@H]1[C@@H](C)OC(C)(C)N1C(=O)OC(C)(C)C>>C#C[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)O,,CO,,Cc1ccc(S(=O)(=O)O)cc1,O,val
US20070083063A1,CC#N.CC(C)O.CCCC(CCC)C(=O)O.CO.C[O-].C[O-].[Mg+2]>>CCCC(CCC)C(=O)[O-].CCCC(CCC)C(=O)[O-].O.[Mg+2],,CC(C)O,CO,,,val
US20150266857A1,COCCS(=O)(=O)Cl.NC(=O)Cn1c(=O)oc2cc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)ccc21>>COCCS(=O)(=O)NCc1nc2ccc(-c3c[nH]c4cc(F)ccc34)cc2o1,,ClCCl,,,,val
US04942154,CC(=O)OC[C@H]1O[C@H](S)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OCCCCCCI)CC[C@]4(C)[C@H]3CC[C@]12C>>CC(=O)OC[C@H]1O[C@H](SCCCCCCO[C@H]2CC[C@@]3(C)C(=CC[C@H]4[C@@H]5CC[C@H]([C@H](C)CCCC(C)C)[C@@]5(C)CC[C@@H]43)C2)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,,ClCCl,,CCN(CC)CC,,val
US20100144710A1,C1CNCCN1.N#Cc1ccncc1Cl>>N#Cc1ccncc1N1CCNCC1,,CCOC(C)=O,,CC#N,,val
US20120088767A1,COC(=O)c1cc(N2CCOCC2)cc2nc(C)[nH]c12.Cc1c(CBr)cccc1C(F)(F)F>>COC(=O)c1cc(N2CCOCC2)cc2c1nc(C)n2Cc1cccc(C(F)(F)F)c1C,,CN(C)C=O,CO,O,O=C([O-])[O-].[K+].[K+],val
US20070203105A1,CCCC[Sn](CCCC)(CCCC)c1cccnn1.C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(Br)cc3)C[C@]2(C)[C@H]1C(=O)C1CC1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1>>C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(-c4ccnnc4)cc3)C[C@]2(C)[C@H]1C(=O)C1CC1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O,,val
US20130240796A1,Brc1ccc2[nH]c3ccccc3c2c1.CC1(C)c2ccccc2-c2cc3c4cc(B(O)O)ccc4n(-c4ccccc4)c3cc21>>CC1(C)c2ccccc2-c2cc3c4cc(-c5ccc6[nH]c7ccccc7c6c5)ccc4n(-c4ccccc4)c3cc21,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,O,Cc1ccccc1,O=C([O-])[O-].[Na+].[Na+],val
US20020025970A1,COC(=O)CBr.COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1OC>>COC(=O)CN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)C(OC)C1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110021489A1,CNCCO.O=C(N1CCOCC1)N1CC(c2ccc(C(F)(F)F)cc2)CC(c2nc(Cl)no2)C1>>CN(CCO)c1noc(C2CC(c3ccc(C(F)(F)F)cc3)CN(C(=O)N3CCOCC3)C2)n1,,CCO,,,,val
US20140315949A1,COC(=O)c1ccc(C(C)OC(C)C)cc1>>CC(C)OC(C)c1ccc(C(=O)O)cc1,,CO,O,Cl,[Li+].[OH-],val
US20120264737A1,CCc1cc(C2CCC2)c(C(N)=S)cc1C(=O)OC.CI>>CCc1cc(C2CCC2)c(C(=N)SC)cc1C(=O)OC,,C1CCOC1,,,,val
US20140100373A1,O=Cc1c[nH]cn1.O=S(=O)(Cl)c1ccccc1>>O=Cc1cn(S(=O)(=O)c2ccccc2)cn1,,C1CCOC1,O,CC#N,CCN(CC)CC,val
US20100249126A1,CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])cn2)CC1>>O=[N+]([O-])c1ccc(OC2CCNCC2)nc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05444082,OC1CCC2(CC1)CCC(C=Cc1ccoc1)CC2>>OC1CCC2(CC1)CCC(CCc1ccoc1)CC2,[Pd],CCO,,,,val
US06858739B2,COc1ccc(-c2cc3cc(F)c(F)cc3[nH]2)cc1N.CS(=O)(=O)OS(C)(=O)=O>>COc1ccc(-c2cc3cc(F)c(F)cc3[nH]2)cc1NS(C)(=O)=O,,O,,Cl,c1ccncc1,val
US07033765B1,Cc1cccc(C)c1N.O=C(O)CBr>>Cc1cccc(C)c1NC(=O)CBr,,ClCCl,,,,val
US04992437,CCOC(=O)OCC.CCc1cc2c(s1)-n1c(C)nnc1CN=C2c1ccccc1Cl.NOc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]>>CCOC(=O)C1(N)N=C(c2ccccc2Cl)c2cc(CC)sc2-n2c(C)nnc21,,CC(=O)O,,[H][H],[H-].[Na+],val
US20070232583A1,CC(C)(C)NS(=O)(=O)c1cccc(-c2cccc(-c3cc(-c4ccc(C(F)(F)F)cc4)cc(COC4CCCCO4)n3)n2)c1>>NS(=O)(=O)c1cccc(-c2cccc(-c3cc(-c4ccc(C(F)(F)F)cc4)cc(CO)n3)n2)c1,,[Na+],[OH-],O=C(O)C(F)(F)F,,val
US20140107168A1,CCN(CC)CC(=O)Nc1cccc([N+](=O)[O-])c1>>CCN(CC)CC(=O)Nc1cccc(N)c1,[Pd],C1CCOC1,,,,val
US20140045890A1,C#C[Si](C)(C)C.CC(C)(C)OC(=O)NC(C)(C)/C(Cl)=N/O>>CC(C)(C)OC(=O)NC(C)(C)c1cc([Si](C)(C)C)on1,,CCOC(C)=O,COCCOC,,,val
US20100249139A1,CC(c1ccc(O)cc1Cl)C(O)(c1ccnc(Cl)c1)C(F)(F)F.N#Cc1ccc(F)c(F)c1>>CC(c1ccc(Oc2ccc(C#N)cc2F)cc1Cl)C(O)(c1ccnc(Cl)c1)C(F)(F)F,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030153506A1,CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCc1ccc(C#N)cc1>>CC(C)C[C@H](N)C(=O)NCc1ccc(C#N)cc1,,Cl,,,,val
US06297258B1,N#Cc1cnc2cc(N3CCOCC3)c(N)cc2c1Nc1ccc(F)c(Cl)c1.O=C(O)CCCl>>N#Cc1cnc2cc(N3CCOCC3)c(NC(=O)CCCl)cc2c1Nc1ccc(F)c(Cl)c1,,ClCCl,,C(=NC1CCCCC1)=NC1CCCCC1,,val
US20160221945A1,COC(=O)c1cnc(C#N)cc1-c1ccc(C(F)(F)F)nc1.Cl>>COC(=O)c1cnc(CN)cc1-c1ccc(C(F)(F)F)nc1.Cl,[Pd],CO,,,,val
US20080153836A1,COC(=O)c1ccc(CO)cc1NC(C)=O>>COC(=O)c1ccc(C=O)cc1NC(C)=O,O=[Mn]=O,ClCCl,,,,val
US05900426,COCCOCOc1ccc(C(=O)c2nc3ccc(OCOCCOC)cc3s2)cc1>>O=C(c1ccc(O)cc1)c1nc2ccc(O)cc2s1,,CO,O,O=C(O)C(F)(F)F,,val
US20090253758A1,Cc1c(N[C@@H](c2nnc(-c3ccc(Br)cc3)o2)[C@H](C)O[Si](C)(C)C(C)(C)C)ccc(C#N)c1Cl>>Cc1c(N[C@@H](c2nnc(-c3ccc(Br)cc3)o2)[C@H](C)O)ccc(C#N)c1Cl,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20090131397A1,COC(=O)C1(c2onc(-c3ccc(O[Si](C)(C)C(C)(C)C)cc3)c2-c2ccccc2)CC1>>COC(=O)C1(c2onc(-c3ccc(O)cc3)c2-c2ccccc2)CC1,,C1COCCO1,,Cl,O=C([O-])O.[Na+],val
US20110269652A1,CCCCCCCCOCC(COCCCCCCCC)(COCC[NH+](CC)CC)COCC[NH+](CC)CC>>CCCCCCCCOCC(COCCCCCCCC)(COCCN(CC)CC)COCCN(CC)CC,,[Na+],[OH-],Cl,Cl,val
US20090156590A1,CCOC(=O)C(C)c1ccc2nc(NC(=O)OC(C)(C)C)sc2c1>>CC(C(=O)O)c1ccc2nc(NC(=O)OC(C)(C)C)sc2c1,,C1CCOC1,O,CC(=O)O,[Na+].[OH-],val
US20080182876A1,II.OCCCOC/C=C/c1ccc2c(c1)OCCO2>>ICCCOC/C=C/c1ccc2c(c1)OCCO2,,Cc1ccccc1,,c1c[nH]cn1,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100113438A1,CN1CCC(Cc2ccc(C(=O)/C=C/c3ccc(/C=C/C(=O)O)cc3)cc2)CC1.Cl.NOC1CCCCO1>>CN1CCC(Cc2ccc(C(=O)/C=C/c3ccc(/C=C/C(=O)NO)cc3)cc2)CC1.Cl,,C1CCOC1,,ClCCCl,On1nnc2ccccc21,val
US20050143452A1,C=CCc1cccc([N+](=O)[O-])c1O.O=C(OO)c1cccc(Cl)c1>>O=[N+]([O-])c1cccc2c1OC(CO)C2,,CO,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US05484689,CCCc1ccccc1.O=CC(=O)c1ccccc1>>CCCc1ccc(C(O)C(=O)c2ccccc2)cc1,Cl[Ti](Cl)(Cl)Cl,CC(Cl)Cl,,O,,val
US20150266862A1,CC(C)(C)OC(=O)N1CCC(C=O)C1>>CC(C)(C)OC(=O)N1CCC(CO)C1,,CO,,[BH4-].[Na+],,val
US04935442,C1COCCN1.C=O.CC(C)(C)CC(C)(C)c1ccc(O)c(OCC2(C)CCC(CO)O2)c1>>CC(C)(C)CC(C)(C)c1cc(CN2CCOCC2)c(O)c(OCC2(C)CCC(CO)O2)c1,,CC(C)O,,,,val
US20080255078A1,CCCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1cccc(OCCOCCOC(C)=O)c1>>CCCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1cccc(OCCOCCO)c1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20060100193A1,O=C(NCc1cc(-c2ccc(I)cc2)no1)c1ccc(Cl)s1.Oc1ccccn1>>O=C(NCc1cc(-c2ccc(-n3ccccc3=O)cc2)no1)c1ccc(Cl)s1,[Cu]I,C1COCCO1,CS(C)=O,CNCCNC,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US04883794,BrCc1ccccc1.O=c1c2ccccc2[nH]n2cccc12>>O=c1c2ccccc2n(Cc2ccccc2)n2cccc12,,CCC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20050256147A1,BrCc1ccccc1.ClCCCOc1ccc2c(c1)[C@@]13CCCC[C@H]1[C@@H](C2)NCC3>>ClCCCOc1ccc2c(c1)[C@@]13CCCC[C@H]1[C@@H](C2)N(Cc1ccccc1)CC3,,CN(C)C=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20150197519A1,CC(=O)CCl.Nc1cc(Br)c(F)cc1O>>CC1=Nc2cc(Br)c(F)cc2OC1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20100204240A1,CON(C)C(=O)[C@]1(C)COC(C)(C)O1>>CC1(C)OC[C@@](C)(C=O)O1,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20060264490A1,CC(=O)Nc1ccc(F)c([N+](=O)[O-])c1.NCC1CC=C(F)CC1>>CC(=O)Nc1ccc(NCC2CC=C(F)CC2)c([N+](=O)[O-])c1,,CCO,,Cl,,val
US20100267768A1,CC(C)(C)c1cc(C(C)(C)C(=O)O)c(O)cc1[N+](=O)[O-]>>CC(C)(C)c1cc2c(cc1[N+](=O)[O-])OC(=O)C2(C)C,,C1CCOC1,,CCN=C=NCCCN(C)C,,val
US04440769,COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC>>c1ccc2ncncc2c1,,COCCOC,,CCN(CC)CC,,val
US20110245308A1,COc1cc(C)ccc1C(=O)NC(C)(C)C.O=C1CCC(=O)N1Br>>COc1cc(CBr)ccc1C(=O)NC(C)(C)C,,ClC(Cl)(Cl)Cl,ClCCl,,,val
US20030069297A1,Cc1cc(C(=O)NCCn2ccnn2)c(C=O)[nH]1.O=C1Cc2c(cccc2-c2ccc(Br)cc2)N1>>Cc1cc(C(=O)NCCn2ccnn2)c(C=C2C(=O)Nc3cccc(-c4ccc(Br)cc4)c32)[nH]1,C1CCNCC1,CCO,,,,val
US06423717B1,COc1ccc([NH-])cc1N1CCN(C(=O)OC(C)(C)C)CC1.Cc1c(S(=O)(=O)O)sc2ccc(Cl)cc12.Cl>>COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCNCC1.Cl,,C1CCOC1,Cl,,,val
US20120149573A1,CCOC(=O)c1cnc(-c2ccsc2)n(CCOC)c1=O>>COCCn1c(-c2ccsc2)ncc(C(=O)O)c1=O,,CCOC(C)=O,,[I-].[Li+],,val
US20060079687A1,COC(OC)c1cc(Oc2cccc(N(C(=O)OCc3ccccc3)C3CCCCC3)c2)ccc1[N+](=O)[O-]>>O=Cc1cc(Oc2cccc(N(C(=O)OCc3ccccc3)C3CCCCC3)c2)ccc1[N+](=O)[O-],,C1CCOC1,,Cl,O,val
US20060211603A1,COC(=O)c1cc(C(C)C)no1>>CC(C)c1cc(C(=O)O)on1,,CO,,[Li+].[OH-],,val
US20050075512A1,NC(CNC(=O)c1ccccc1)c1ccccc1.O=C(Cl)OCc1ccccc1>>O=C(NC(CNC(=O)c1ccccc1)c1ccccc1)OCc1ccccc1,,ClCCl,,CCN(CC)CC,Cl,val
US20140100231A1,COc1nnc(Cn2cnc(C(F)(F)F)c(Oc3cc(Cl)cc(C#N)c3)c2=O)cc1C(O)C1CC1>>N#Cc1cc(Cl)cc(Oc2c(C(F)(F)F)ncn(Cc3cc(C(O)C4CC4)c(=O)[nH]n3)c2=O)c1,,CN(C)C=O,,[Cl-].[Li+],,val
US20070078184A1,BrCc1ccccc1.CCOC(=O)COc1ccc(-c2ccc(O)cc2)cc1>>CCOC(=O)COc1ccc(-c2ccc(OCc3ccccc3)cc2)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110053953A1,CI.Cc1cc(Br)cnc1C(=O)O>>COC(=O)c1ncc(Br)cc1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06586633B1,CC(C)(C)c1ccc(CBr)cc1.CN>>CC(C)(C)c1ccc(CCN)cc1,,CO,,O=C([O-])[O-].[Na+].[Na+],,val
US20040132733A1,CI.COC(=O)C[C@H]1Nc2ccccc2NC1=O>>COC(=O)C[C@H]1Nc2ccccc2N(C)C1=O,,CN(C)C=O,O,[H-].[Na+],,val
US20130190316A1,CCOC(=O)CNN.CN(C)/C=C/C(=O)c1ncccc1CO[Si](C)(C)C(C)(C)C>>CCOC(=O)Cn1nccc1-c1ncccc1CO,,CCO,,Cl,Cl,val
US20120022045A1,CC(C)(C)OC(=O)NC1(c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)[nH]2)CCC(CO[Si](C)(C)C(C)(C)C)CC1>>CC(C)(C)OC(=O)NC1(c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)[nH]2)CCC(CO)CC1,,C1CCOC1,,CC(=O)O,O,val
US20090298815A1,COC(=O)c1cccc(NS(=O)(=O)c2cc(F)ccc2F)c1F.Cc1ccnc(Cl)n1>>O=C(Cc1ccnc(Cl)n1)c1cccc(NS(=O)(=O)c2cc(F)ccc2F)c1F,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120094996A1,Brc1nn2c(I)cnc2s1.CCn1cc(B(O)O)cn1>>CCn1cc(-c2nn3c(I)cnc3s2)cn1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,,O=C([O-])[O-].[Na+].[Na+],,val
USRE033024,COc1ccc(C[C@H](C)N(C[C@@H](O)c2ccc(OCc3ccccc3)c3[nH]c(=O)ccc23)C(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc3ccccc3c2)cc1>>COc1ccc(C[C@H](C)NC[C@@H](O)c2ccc(OCc3ccccc3)c3[nH]c(=O)ccc23)cc1,,CO,,O,[K+].[OH-],val
US20120122840A1,COc1cc(N2CCC(N3CCCC(O)C3)CC2)ccc1[N+](=O)[O-]>>COc1cc(N2CCC(N3CCCC(O)C3)CC2)ccc1N,[Pd],CO,,,,val
US20030055047A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCc1cccnc1>>CN(Cc1cccnc1)C(=O)OC(C)(C)C,,ClCCl,,,,val
US20110053907A1,CC(C)(C)OC(=O)N1CCNCC1.Clc1nc(Cl)nc(N2CCOCC2)n1>>CC(C)(C)OC(=O)N1CCN(c2nc(Cl)nc(N3CCOCC3)n2)CC1,,CC(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20030232838A1,CCCn1c(C)c([N+](=O)[O-])c(=O)n(C)c1=O.CCOc1ccccc1C=O>>CCCn1c(/C=C/c2ccccc2OCC)c([N+](=O)[O-])c(=O)n(C)c1=O,,CCO,,C1CCNCC1,,val
US20100204159A1,C=CCCCCCCOc1cccc(S(N)(=O)=O)c1.C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)O>>C=CCCCCCCOc1cccc(S(=O)(=O)NC(=O)[C@@]2(NC(=O)OC(C)(C)C)C[C@H]2C=C)c1,,C1CCOC1,CCOC(C)=O,C1CCC2=NCCCN2CC1,O=C(n1ccnc1)n1ccnc1,val
US20050065143A1,CC1CN(c2ccc(C(=O)NCCC3CC3)nn2)CC(C)N1.O=C(Cl)c1ccccc1C(F)(F)F>>CC1CN(c2ccc(C(=O)NCCC3CC3)nn2)CC(C)N1C(=O)c1ccccc1C(F)(F)F,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US06703082B1,BrP(Br)Br.OCc1ccc2cc(OCc3ccccc3)ccc2c1>>BrCc1ccc2cc(OCc3ccccc3)ccc2c1,,ClCCl,,,,val
US04001254,CCN(CC)CC.CCO.O=[N+]([O-])c1ccc(Cl)nc1>>CCCCCCNc1ccc([N+](=O)[O-])cn1,,CCO,,,,val
US20030130340A1,CC(=O)OC(C)=O.Nc1ccc2c(-c3cccnc3)csc2c1>>CC(=O)Nc1ccc2c(-c3cccnc3)csc2c1,,c1ccncc1,,,,val
US04130568,COc1c2c(cc3ccc(=O)oc13)CC(OC)O2>>COc1c2occc2cc2ccc(=O)oc12,,O=CO,,,,val
US20060046999A1,COc1ccc(N)cc1.N#CCC(=O)c1ccc(F)cc1F>>COc1ccc(NC(=N)CC(=O)c2ccc(F)cc2F)cc1,,CCO,,,,val
US05635477,COC(=O)c1ccc2cccc(C#N)c2c1>>COC(=O)c1ccc2cccc(CN)c2c1,[Pd],CO,,Cl,,val
US04753674,CCC(Oc1cccc([N+](=O)[O-])c1)C(=O)Cl.NCc1ccccc1>>CCC(Oc1cccc([N+](=O)[O-])c1)C(=O)NCc1ccccc1,,Cc1ccccc1,,c1ccncc1,,val
US20040092737A1,CI.O=C(O)C(O)c1ccc2c(c1)Nc1nccnc1S2>>COC(=O)C(O)c1ccc2c(c1)Nc1nccnc1S2,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20140194406A1,C#C[Si](C)(C)C.CN1CCN(C(=O)c2cccc(I)c2)CC1>>CN1CCN(C(=O)c2cccc(C#C[Si](C)(C)C)c2)CC1,[Cu]I,CC#N,CCOC(C)=O,,,val
US04210754,CCC1CO1.S=C(NCCN1CCOCC1)c1ccc(Cl)cc1>>O=C(NCCN1CCOCC1)c1ccc(Cl)cc1,,CO,,Cl,,val
US20110195961A1,O=C1CSc2ccc(N3C[C@H](CCCN[C@@H]4Cn5c(=O)cnc6ccc(F)c4c65)OC3=O)cc2N1>>O=C1CSc2ccc(N3C[C@H](CCCN[C@@H]4CN5C(=O)CNc6ccc(F)c4c65)OC3=O)cc2N1,,CO,ClCCl,[BH4-].[Na+],,val
US20090186886A1,CC(=O)Nc1ccc2c(c1[N+](=O)[O-])CCC2>>Nc1ccc2c(c1[N+](=O)[O-])CCC2,,Cl,O,,,val
US20120010183A1,CC(C)n1ncc2cc(O)ccc21.CS(=O)(=O)NC(=O)c1cc(Cl)c(F)cc1F>>CC(C)n1ncc2cc(Oc3cc(F)c(C(=O)NS(C)(=O)=O)cc3Cl)ccc21,,C1CCOC1,,[H-].[Na+],,val
US20140057299A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC1CC(=O)Nc2cc(O)ccc21>>CC(C)(C)OC(=O)NCC1CC(=O)Nc2cc(O)ccc21,,CO,,CCN(CC)CC,,val
US20110230462A1,BrCC1CC1.Ic1c[nH]cn1>>Ic1cn(CC2CC2)cn1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20070249596A1,NNc1ccccc1.O=C/C(Cl)=C(/Cl)C(=O)O>>O=c1c(Cl)c(Cl)cnn1-c1ccccc1,,CCO,,,,val
US20060035898A1,CCOC(=O)c1cncc(-c2cnc3c(c2)c(-c2ccccc2OC)nn3COCC[Si](C)(C)C)c1>>COc1ccccc1-c1n[nH]c2ncc(-c3cncc(C(=O)O)c3)cc12,,C1CCOC1,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20050107343A1,CC(C)c1c[nH]c2nc(N)nc(Cl)c12.COc1c(C)cnc(CCl)c1C>>COc1c(C)cnc(Cn2cc(C(C)C)c3c(Cl)nc(N)nc32)c1C,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20050065191A1,Cc1cccc(C#CC2(O)CCCC3CN(C(=O)OC(C)(C)C)CC32)c1>>Cc1cccc(C#CC2(O)CCCC3CNCC32)c1,,CCOC(C)=O,,Cl,,val
US20150158855A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Ic1cccc(C[C@@H]2COCCN2)c1>>CC(C)(C)OC(=O)N1CCOC[C@H]1Cc1cccc(I)c1,,ClCCl,,CCN(CC)CC,,val
US20110122475A1,COc1cc(-c2ccc(-c3ccccc3)s2)c2ccccc2c1>>Oc1cc(-c2ccc(-c3ccccc3)s2)c2ccccc2c1,,ClCCl,,BrB(Br)Br,O,val
US07094798B1,O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1c2c2cc(O)ccc2n1CCCBr.Sc1ccccc1>>O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1c2c2cc(O)ccc2n1CCCSc1ccccc1,,C1COCCO1,,CCN(CC)CC,O,val
US05202344,CCOC(=O)CC1CN(c2ccccc2)C(=O)C1=NO>>CCOC(=O)CC1CN(c2ccccc2)C(=O)C1N,[Pd],CCO,,,,val
US20050014748A1,NCC1CCN(C(c2ccccc2)c2ccccc2)C1.O=C(O)CN(c1ccccc1)c1ccccc1>>O=C(CN(c1ccccc1)c1ccccc1)NCC1CCN(C(c2ccccc2)c2ccccc2)C1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20150119362A1,Clc1cccc(-c2nc(Cl)cc(C3CC3)n2)c1.Nc1ccc(CCO)cc1>>OCCc1ccc(Nc2cc(C3CC3)nc(-c3cccc(Cl)c3)n2)cc1,,CN1CCCC1=O,O,,,val
US04716178,CC(C)(C)c1cc(Nc2ccccc2)cc(C(C)(C)C)c1O.O=C1CCC(=O)O1>>CC(C)(C)c1cc(N(C(=O)CCC(=O)O)c2ccccc2)cc(C(C)(C)C)c1O,,COCCOC,,,,val
US20050053861A1,CS.Fc1ccc([S+](c2ccccc2)c2ccccc2)cc1.O=S(=O)([O-])C(F)(F)F>>CSc1ccc([S+](c2ccccc2)c2ccccc2)cc1.O=S(=O)([O-])C(F)(F)F,,ClCCl,,[Na+].[OH-],,val
US20150307475A1,COc1ccc(Cn2cc(CCCCC(=O)O)nn2)cc1>>O=C(O)CCCCc1c[nH]nn1,[Pd],CCO,,,,val
US20100076026A1,CCCCN(C(=O)NC1CCCCC1)c1c2ccccc2nn1-c1ccc(Cl)cc1.CCOc1cccc(N)c1>>CCOc1cccc(Nc2c3ccccc3nn2-c2ccc(Cl)cc2)c1,,CN1CCCC1=O,,,,val
US04003914,CNCCc1ccc(OC)c(OC)c1.COc1ccc(C2(CCCCl)S(=O)(=O)CCCS2(=O)=O)cc1OC>>CNCCCC1S(=O)(=O)CCCS1(=O)=O.Cl,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20160060273A1,COC(=O)c1cc(Br)c(C2CCC2)cc1OCc1ccccc1.OB(O)C1CC1>>COC(=O)c1cc(C2CC2)c(C2CCC2)cc1OCc1ccccc1,,Cc1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],,val
US05464863,Cc1cccc(C)c1N.O=C(O)c1sc2ccc(Cl)cc2c1-c1ccccc1Cl.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cc1cccc(C)c1NC(=O)Nc1sc2ccc(Cl)cc2c1-c1ccccc1Cl,,O,c1ccccc1,CCN(CC)CC,,val
US20120004222A1,CON(C)C(=O)c1nc(Br)n2ccccc12>>O=Cc1nc(Br)n2ccccc12,,C1CCOC1,,CC(C)C[AlH]CC(C)C,,val
US20090131492A1,CC1(C)OC[C@H](Cn2c(C(C)(C)CO)cc3cc([N+](=O)[O-])c(F)cc32)O1>>CC1(C)OC[C@H](Cn2c(C(C)(C)CO)cc3cc(N)c(F)cc32)O1,,CCO,,,,val
US07452950B2,C1=CCOC=C1.Cc1sc(CO)cc1Br>>Cc1sc(COC2CCCCO2)cc1Br,,CO,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080269193A1,Cc1[nH]c2c(c1C)C(=O)CC(C)(C)C2.N#Cc1c(F)cc(Br)cc1NC1CCOCC1>>Cc1c2c(n(-c3cc(F)c(C#N)c(NC4CCOCC4)c3)c1C)CC(C)(C)CC2=O,[Cu]I,C1COCCO1,,CNCCNC,O=C([O-])[O-].[K+].[K+],val
US20080207902A1,CCc1cc2c(C3=NNC(=O)CC3C)cc(F)cn2n1.ClCc1cccnc1>>CCc1cc2c(C3=NN(Cc4cccnc4)C(=O)CC3C)cc(F)cn2n1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20050239751A1,CNOC.O=C(Cl)c1cccnc1>>CON(C)C(=O)c1cccnc1,,ClCCl,,CCN(C(C)C)C(C)C,Cl,val
US06800637B2,C=O.Cc1ccc2c3c(ccc2n1)OC[C@H](CNCCCc1cn(C)c2ccc(C#N)cc12)O3>>Cc1ccc2c3c(ccc2n1)OCC(CN(C)CCCc1cn(C)c2ccc(C#N)cc12)O3,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20090036419A1,C[C@@H](NC(=O)OC(C)(C)C)c1cc(-c2nc3ccc(C(F)(F)F)cc3[nH]2)no1>>C[C@@H](N)c1cc(-c2nc3ccc(C(F)(F)F)cc3[nH]2)no1,,O=C(O)C(F)(F)F,,,,val
US04214097,CCOC(=O)C(C)C(C)(C)C=CCBr>>C=CC1C(C)(C)C1(C)C(=O)OCC,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US04533664,CN1C(C(=O)Nc2ccccc2)=C(O)c2ccccc2S1(=O)=O.Nc1cncc(Cl)n1>>CN1C(C(=O)Nc2cncc(Cl)n2)=C(O)c2ccccc2S1(=O)=O,,Cc1ccccc1C,,Cc1ccc(S(=O)(=O)O)cc1,,val
US04024142,N.O=[N+]([O-])c1cc(C(F)(F)F)cc([N+](=O)[O-])c1Cl>>Nc1c([N+](=O)[O-])cc(C(F)(F)F)cc1[N+](=O)[O-],,CCOC(C)=O,,CCO,,val
US20050075499A1,CC(C)(C)OC(=O)N1CC=CCC1>>CC(C)(C)OC(=O)N1CCCCC1,[Pd],CO,,,,val
US04354973,COC(=O)Cl.Clc1ccc2c(c1)C(c1ccccc1Cl)=NCc1c[nH]cc1-2>>COC(=O)n1cc2c(c1)-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2,,CN(C)C=O,O,CC(C)(C)[O-].[K+],,val
US20080234255A1,C=O.NC1CCCC1.c1ccc2[nH]nnc2c1>>c1ccc2c(c1)nnn2CNC1CCCC1,,CCOCC,,,,val
US05032598,BrBr.CS(=O)(=O)Nc1ccc2c(c1)C(=O)CCC2>>CS(=O)(=O)Nc1ccc2c(c1)C(=O)C(Br)CC2,,ClCCl,,,,val
US05576324,Cc1cc2c(c3ccc(=O)[nH]c13)OC(CBr)C2.NCCS>>Cc1cc2c(c3ccc(=O)[nH]c13)OC(CSCCN)C2,,CN(C)C=O,O,Cl,[Na+].[OH-],val
US20090239854A1,C=Cc1ccc(C(F)(F)F)nc1.Cc1ccc2[nH]c3c(c2c1)CN(C)C(C)(C)C3>>Cc1ccc2c(c1)c1c(n2CCc2ccc(C(F)(F)F)nc2)CC(C)(C)N(C)C1,,CN1CCCC1=O,,[K+].[OH-],,val
US20050049259A1,C#CCOC1CCCCO1.O=Cc1c(-c2ccc(F)cc2)nn2c(Cl)cccc12>>OC(C#CCOC1CCCCO1)c1c(-c2ccc(F)cc2)nn2c(Cl)cccc12,,C1CCOC1,CCOCC,O,[Li]CCCC,val
US20100222398A1,CC(=O)Nc1ccc(CC#N)cc1.[N-]=[N+]=Nc1ccc(C(F)(F)F)cc1F>>CC(=O)Nc1ccc(-c2nnn(-c3ccc(C(F)(F)F)cc3F)c2N)cc1,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20100197660A1,CI.O=C1CC=C(c2ccccc2)C=CN1>>CN1C=CC(c2ccccc2)=CCC1=O,,COC(C)(C)C,,C1CCOC1,CC(C)(C)[O-].[K+],val
US05245046,CO.O=C(O)Cc1cccc(C(F)(F)F)c1>>COC(=O)Cc1cccc(C(F)(F)F)c1,,CCOC(C)=O,,,,val
US20020094987A1,CCOC(CC)(OCC)OCC.Nc1c(O)cccc1O>>CCc1nc2c(O)cccc2o1,,CCO,,Cl,O,val
US20020042411A1,CCOC(=O)c1c(Nc2cc(Cl)ccc2N)sc2ccccc12.CN1CCNCC1>>CN1CCN(C2=Nc3ccc(Cl)cc3Nc3sc4ccccc4c32)CC1,Cl[Ti](Cl)(Cl)Cl,COc1ccccc1,,,,val
US20080280933A1,CCOC(OCC)c1nc2cc(F)c(F)cc2[nH]1.CI>>CCOC(OCC)c1nc2cc(F)c(F)cc2n1C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20130137675A1,O=c1c(-c2ccnn2-c2ccccc2)nn(-c2ccc(-n3cccn3)cc2F)c2ccoc12.OCC(F)(F)F>>O=c1c(-c2ccnn2-c2ccccc2)nn(-c2ccc(-n3cccn3)cc2OCC(F)(F)F)c2ccoc12,,CN(C)C=O,,[H-].[Na+],,val
US20060235057A1,BrCc1ccccc1.Oc1cc(Cl)ccc1Br>>Clc1ccc(Br)c(OCc2ccccc2)c1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05476952,CC(=O)OCc1cc2c(c3c1CCC3)C(=O)c1ccccc1C2=O>>O=C1c2ccccc2C(=O)c2c1cc(CO)c1c2CCC1,,CO,,CCN(CC)CC,O,val
US05358939,CCCCC(CO)(Cn1cncn1)c1ccc(Cl)cc1.CI>>CCCCC(COC)(Cn1cncn1)c1ccc(Cl)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20120149699A1,CCOC(=O)c1nc2ccccn2c1C>>Cc1c(C(=O)O)nc2ccccn12,,CO,,[Na+].[OH-],,val
US04699995,C#Cc1cccc(OC)c1.CCCCCCI>>CCCCCCC#Cc1cccc(OC)c1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20080096921A1,CC[C@@H](C)c1onc(-c2c(Cl)cccc2Cl)c1CO.COC(=O)c1ccc2cc(-c3ccc(O)cc3)ccc2n1>>CC[C@@H](C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(-c2ccc3nc(C(=O)OC)ccc3c2)cc1,,ClCCl,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140371278A1,COC(=O)c1cc(SSc2cc(C(=O)OC)c(Nc3ccccc3Cl)c(F)c2N)c(N)c(F)c1Nc1ccccc1Cl>>COC(=O)c1cc(S)c(N)c(F)c1Nc1ccccc1Cl,,C1CCOC1,CO,[BH4-].[Na+],,val
US20140275043A1,CC(C)(C)OC(=O)NCCC(O)c1cccc(S(=O)(=O)CC2CCS(=O)(=O)CC2)c1>>CC(C)(C)OC(=O)NCCC(=O)c1cccc(S(=O)(=O)CC2CCS(=O)(=O)CC2)c1,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20020025968A1,Cc1nc2ccccc2c(=O)[nH]1.O=Cc1cccnc1>>O=c1[nH]c(C=Cc2cccnc2)nc2ccccc12,,CC(=O)O,,,,val
US20090264399A1,CNC1CCCCC1.Clc1ccnc2[nH]ccc12>>CN(c1ccnc2[nH]ccc12)C1CCCCC1,,ClC(Cl)Cl,,Cl,,val
US20040002524A1,COc1ccc(Nc2ccccc2[N+](=O)[O-])c(C)c1>>COc1ccc(Nc2ccccc2N)c(C)c1,[Pd],C1COCCO1,,CO,Cl,val
US20070259881A1,Cc1nc(N)c2nc(CN)n(CC(C)C)c2c1C.O=S(=O)(Cl)CCCCl>>Cc1nc(N)c2nc(CN3CCCS3(=O)=O)n(CC(C)C)c2c1C,,CN(C)C=O,,C1CCC2=NCCCN2CC1,,val
US04987145,Cc1nc2cccc(F)c2[nH]1.O=S(=O)(Oc1ccc(Oc2ccc(CBr)cc2)cc1)C(F)(F)F>>Cc1nc2c(F)cccc2n1Cc1ccc(Oc2ccc(OS(=O)(=O)C(F)(F)F)cc2)cc1,,O,,CN(C)C=O,[H-].[Na+],val
US03957774,C1COCCN1.C=O.NC(=O)NCCS>>O=C(NCCS)NCN1CCOCC1,,O,,,,val
US20160024060A1,COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12.Cl>>COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12.Cl,,CC(C)O,O,,,val
US20080207616A1,CC(C)(C#N)c1cccc(C(=O)O)c1.Nc1ccc(F)c([N+](=O)[O-])c1>>CC(C)(C#N)c1cccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070213371A1,COC(c1ccc(C(F)(F)F)cc1C=O)C1CCCCC1.Cn1nnc(N)n1>>COC(c1ccc(C(F)(F)F)cc1CNc1nnn(C)n1)C1CCCCC1,,Cc1ccccc1,,[BH4-].[Na+],,val
US20090176769A1,CN(C)CCNc1c(F)cccc1CO>>CN(C)CCNc1c(F)cccc1C=O,O=[Mn]=O,Cc1ccccc1,,,,val
US20140051672A1,COB(OC)OC.COc1cc(-n2ccnc2)ccc1Br>>COc1cc(-n2ccnc2)ccc1B(O)O,,C1CCOC1,,[Li]CCCC,,val
US20140288326A1,C=C(C)C1(C)CCC(C)CC1=O.CCCC=NCCCC>>CCCCN1C(=O)C[C@@H](C)CCC(C)=C(C)CC1CCC,,ClCCCl,,Cl[Sn](Cl)(Cl)Cl,,val
US20140179666A1,O=C1Nc2cc(Cl)ccc2C12CC2>>Clc1ccc2c(c1)NCC21CC1,,C1CCOC1,,CO,,val
US20100105700A1,CN1C(=O)CC[C@@]2(C)C1=CC[C@H]1[C@@H]3CCC(=O)[C@@]3(C)CC[C@@H]12.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CN1C(=O)CC[C@@]2(C)C1=CC[C@H]1[C@@H]3CC=C(OS(=O)(=O)C(F)(F)F)[C@@]3(C)CC[C@@H]12,,ClCCl,,O,,val
US20050065151A1,COc1cnc(C2CCOCC2)c2sc(NC(=O)c3ccccc3)nc12>>COc1cnc(C2CCOCC2)c2sc(N)nc12,,CO,,[Na+].[OH-],,val
US04837241,CCOC(=O)C1=CC[NH+](C)CC1.N.[Cl-]>>C[NH+]1CC=C(C(N)=O)CC1.[Cl-],,O,,,,val
US05578620,C[C@H](CO)N1C[C@H](COc2cccc(Cl)c2)OC1=O.O=C1SC(Cc2ccc(O)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1>>C[C@H](COc1ccc(CC2SC(=O)N(C(c3ccccc3)(c3ccccc3)c3ccccc3)C2=O)cc1)N1C[C@H](COc2cccc(Cl)c2)OC1=O,,c1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20110224257A1,CC(C)(C)OC(=O)N1CCC(c2nc(C3=NOC(c4ccccc4O)C3)cs2)CC1.Cl>>Oc1ccccc1C1CC(c2csc(C3CC[NH2+]CC3)n2)=NO1.[Cl-],,C1COCCO1,ClCCl,,,val
US20040127576A1,CCCC[C@]12CCc3cc(OC)ccc3[C@]1(C)CCC(=O)C2>>CCCC[C@]12CCc3cc(O)ccc3[C@]1(C)CCC(=O)C2,,ClCCl,,BrB(Br)Br,,val
US06472348B1,CC(C)Oc1cc(CBr)c(F)cc1Cl.[C-]#N>>CC(C)Oc1cc(CC#N)c(F)cc1Cl,,CN(C)C=O,,O,,val
US20040242869A1,COc1ccc(-c2c3c(nn2-c2ccccc2)-c2cccc(N)c2C3=O)cc1.O=C(Cl)CCl>>COc1ccc(-c2[nH]nc3c2C(=O)c2c(NC(=O)CCl)cccc2-3)cc1,,C1COCCO1,,O,O=C([O-])O.[Na+],val
US20080058320A1,Brc1ccc2[nH]nc(I)c2c1.CI>>Cn1nc(I)c2cc(Br)ccc21,,CO,,C[O-].[Na+],,val
US20080139390A1,BrC(Br)(Br)Br.Cc1nsc(C#N)c1CO>>Cc1nsc(C#N)c1CBr,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20120172374A1,COc1ccc(Cc2nnc(N)s2)cc1.Cc1ccc(CCC(=O)Cl)o1>>COc1ccc(Cc2nnc(NC(=O)CCc3ccc(C)o3)s2)cc1,,C1COCCO1,,CCN(CC)CC,,val
US20140323463A1,C=O.O[C@@H]1CCC[C@@H]1NCc1ccccc1>>CN(Cc1ccccc1)[C@H]1CCC[C@H]1O,,ClCCCl,,Cl,O=C([O-])O.[Na+],val
US20120196869A1,CC(C)Br.Cc1nc(Br)ccc1O>>Cc1nc(Br)ccc1OC(C)C,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20140274703A1,COC(=O)c1nc(-c2ccc(C3CC3)nc2)c(F)c(N)c1Cl>>Nc1c(F)c(-c2ccc(C3CC3)nc2)nc(C(=O)O)c1Cl,,CO,,Cl,[Na+].[OH-],val
US04002623,O=C(Nc1nc2ccccc2n1CCCN1CCN(Cc2ccccc2)CC1)c1ccc(C(F)(F)F)cc1>>O=C(Nc1nc2ccccc2n1CCCN1CCNCC1)c1ccc(C(F)(F)F)cc1,[Pd],CC(=O)O,,CCO,[H][H],val
US20050080138A1,CNC(C)c1nccc(=O)n1-c1ccc(F)cc1.O=C=Nc1cccc(C(F)(F)F)c1>>CC(c1nccc(=O)n1-c1ccc(F)cc1)N(C)C(=O)Nc1cccc(C(F)(F)F)c1,,ClC(Cl)Cl,,,,val
US05229403,CCS(=O)(=O)Nc1ncc(C(F)(F)F)cc1N.O=C(O)C1CCCCC1>>CCS(=O)(=O)Nc1ncc(C(F)(F)F)cc1NC(=O)C1CCCCC1,,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20100286088A1,COc1ccc(CC(=O)O)c(OC)c1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COc1ccc(CN=C=O)c(OC)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20070287725A1,O=[N+]([O-])c1c(Cl)nc2ccccc2c1NCCc1cc(-c2ccc(F)cc2)no1>>Nc1c(Cl)nc2ccccc2c1NCCc1cc(-c2ccc(F)cc2)no1,[Pt],CC#N,,,,val
US05039805,CC(C)(C)OC(=O)NC(=N)c1ccc(C(=O)Nc2cc(C(=O)NCCC(=O)O)ccc2OCc2ccccc2)cc1>>N=C(N)c1ccc(C(=O)Nc2cc(C(=O)NCCC(=O)O)ccc2OCc2ccccc2)cc1,,O=CO,,,,val
US20020193367A1,CC(C)(C)OC(=O)Nc1cc(OCC(F)(F)F)c(C(F)(F)F)cc1[N+](=O)[O-]>>CC(C)(C)OC(=O)Nc1cc(OCC(F)(F)F)c(C(F)(F)F)cc1N,[Pt],,,,,val
US20160016908A1,CC(=O)N1c2ccc(C(=O)O)cc2[C@H](Nc2cccc(C)n2)[C@@H](C)[C@@H]1C1CC1.NCCN1CCOCC1>>CC(=O)N1c2ccc(C(=O)NCCN3CCOCC3)cc2[C@H](Nc2cccc(C)n2)[C@@H](C)[C@@H]1C1CC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20090149425A1,C#CCOc1ncc(C=O)s1.N#CCC#N>>C#CCOc1ncc(C=C(C#N)C#N)s1,,CCO,O,,,val
US06329392B1,COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(O[Si](C)(C)C(C)(C)C)cc3)C2)cc(OC)c1OC>>COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(O)cc3)C2)cc(OC)c1OC,,ClCCl,,C1CCOC1,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20160137636A1,COc1ncc(Cl)cc1-c1nccc2cc(S(=O)(=O)Nc3ccncn3)ccc12.OB(O)c1ccccc1>>COc1ncc(-c2ccccc2)cc1-c1nccc2cc(S(=O)(=O)Nc3ccncn3)ccc12,,C1COCCO1,,O,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20080274907A1,CCNc1cc(OCc2ccccc2)ccc1OC.COC(=O)CCCI>>CCN(CCCC(=O)OC)c1cc(OCc2ccccc2)ccc1OC,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,,val
US20160222028A1,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2c(c1)OC1CC2N(Cc2ccccc2)C1>>O=S(=O)(Oc1ccc2c(c1)OC1CC2N(Cc2ccccc2)C1)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US07034015B2,Cc1ccc(S(=O)(=O)Cl)cc1.OCCc1ccccc1Br>>Cc1ccc(S(=O)(=O)OCCc2ccccc2Br)cc1,,c1ccncc1,,,,val
US20060229286A1,ClCc1ccccc1.O=C(O)c1ccc2[nH]ccc2c1>>O=C(OCc1ccccc1)c1ccc2[nH]ccc2c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Ca+2],,val
US06207678B1,c1ccc(C23CCN(CC2)CC3)cc1>>C1CCC(C23CCN(CC2)CC3)CC1,[Rh],CC(=O)O,O,N,,val
US20100135999A1,COC(=O)[C@H](CC(F)F)NC(=O)OCc1ccccc1>>O=C(N[C@@H](CC(F)F)C(=O)O)OCc1ccccc1,,C1CCOC1,O,[Li+].[OH-],,val
US20130190324A1,CN(C)CCCC(=O)O.Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1>>Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(=O)(=O)NC(=O)CCCN(C)C)cc2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100152445A1,CC(C)(C)OC(=O)c1ccc(N2CCC(c3ccc(NC(=O)c4nc(-c5ccccc5)oc4C(F)(F)F)cc3)CC2)cc1>>O=C(O)c1ccc(N2CCC(c3ccc(NC(=O)c4nc(-c5ccccc5)oc4C(F)(F)F)cc3)CC2)cc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US05773423,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.COC1OC(CO)C(O)C1O>>CO[C@@H]1O[C@H](C(O)[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)[C@@H](O)[C@H]1O,CN(C)c1ccncc1,ClCCl,,CCN(CC)CC,,val
US20020169200A1,CCCC(CC(=O)OCC)n1ccc2cc(CCCc3ccc4cccnc4n3)ccc21>>CCCC(CC(=O)OCC)n1ccc2cc(CCCc3ccc4c(n3)NCCC4)ccc21,[Pd],CO,,,,val
US20040259910A1,CCOC(=O)c1cnc(C(=O)c2cccc(OC(C)C)c2)c2cc(OC)c(OCCN3CCCC3)cc12>>COc1cc2c(C(=O)c3cccc(OC(C)C)c3)ncc(C(=O)O)c2cc1OCCN1CCCC1,,C1CCOC1,CCO,[Na+].[OH-],,val
US20110135650A1,CC(C)(C)OC(=O)Nc1ncnc2cc([N+](=O)[O-])ccc12>>CC(C)(C)OC(=O)Nc1ncnc2cc(N)ccc12,[Pd],C1CCOC1,CO,,,val
US20020119961A1,O=C1NCC2CCC1N2Cc1ccc(F)cc1>>Fc1ccc(CN2C3CCC2CNC3)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080004302A1,CC(C)Oc1cc(Nc2ccnc(Cl)n2)[nH]n1.NCc1cc(C2CCC2)no1>>CC(C)Oc1cc(Nc2ccnc(NCc3cc(C4CCC4)no3)n2)n[nH]1,,CCO,,,,val
US20060205737A1,CC(Nc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1[N+](=O)[O-])c1cccc(Cl)c1.Cl>>CC(Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-])c1cccc(Cl)c1.Cl,,CCOCC,ClCCl,,,val
US20120316192A1,CCOC(=O)C#CC(=O)OCC.COc1ccc2[nH]cc(CCN)c2c1.O=Cc1coc2ccc(Br)cc2c1=O>>CCOC(=O)C1=CC(C(=O)c2cc(Br)ccc2O)=CN2CCc3c([nH]c4ccc(OC)cc34)C12C(=O)OCC,,Cc1ccccc1,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20140243194A1,C#CCBr.CCC(O)(Cn1cncn1)c1ccc(Oc2ccc(Cl)cc2)cc1Cl>>C#CCOC(CC)(Cn1cncn1)c1ccc(Oc2ccc(Cl)cc2)cc1Cl,,C1CCOC1,,[H-].[Na+],,val
US20060025459A1,CCCN(CCC)C(=O)c1cc(N)cc(C(=O)OC)c1.O=C(Cl)CCCCl>>CCCN(CCC)C(=O)c1cc(NC(=O)CCCCl)cc(C(=O)OC)c1,,ClCCl,,CCN(CC)CC,,val
US20110319406A1,C1CCNC1.N#Cc1cccc([N+](=O)[O-])c1CBr>>N#Cc1cccc([N+](=O)[O-])c1CN1CCCC1,,ClCCl,,CCN(CC)CC,,val
US04085142,BrCCCCOC1=C(c2ccccc2)CCCC1=Cc1ccccc1.CCN>>CCNCCCCOC1=C(c2ccccc2)CCCC1=Cc1ccccc1,,Cc1ccccc1,,,,val
US04857227,BrCc1ccccc1.N#Cc1ccc(-c2ccc(O)cc2)cc1>>N#Cc1ccc(-c2ccc(OCc3ccccc3)cc2)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20050239752A1,CCc1cccc2c3c([nH]c12)C(CC)(CC(N)=O)OCC3>>CCc1cccc2c3c([nH]c12)C(CC)(CC=N)OCC3,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20030013708A1,COc1cc(Br)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1.C[Si](C)(C)CCOCCl>>COc1cc(Br)c2nc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(OCOCC[Si](C)(C)C)c2c1,,CN1CCCC1=O,CO,O,[H-].[Na+],val
US20140088117A1,C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CCCP(=O)=O.CCN(C(C)C)C(C)C.CO.NN.Nc1sc(-c2c(F)cccc2F)nc1C(=O)O>>Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1OCC(CN)CO1,[Pd],C1CCOC1,CCO,O=C[O-].[NH4+],,val
US20120245175A1,COC(=O)C1(CN)CCN(C(=O)OC(C)(C)C)CC1.COc1ccc(C=O)cc1>>COC(=O)C1(CNCc2ccc(OC)cc2)CCN(C(=O)OC(C)(C)C)CC1,,CO,,[BH3-]C#N.[Na+],,val
US20150336962A1,N#CCCN.O=C1CCC(=CCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1>>N#CCCNC1CCC(=CCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,,CO,,[BH3-]C#N.[Na+],,val
US20040157866A1,CC(C)(C)ON=O.Nc1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)ccc1NCCc1ccccn1>>O=C(Nc1ccc2c(c1)nnn2CCc1ccccn1)c1ccccc1-c1ccc(C(F)(F)F)cc1,,C1CCOC1,,,,val
US20050054733A1,Cc1c(Br)ccc(F)c1F.N#C[Cu]C#N>>Cc1c(C#N)ccc(F)c1F,I[Cu]I,CN(C)C=O,,,,val
US20160028021A1,Ic1cccc2c1[se]c1ccccc12.OB(O)c1ccc(-c2ccccc2)cc1>>c1ccc(-c2ccc(-c3cccc4c3[se]c3ccccc34)cc2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,O,O=C([O-])[O-].[K+].[K+],,val
US20070129416A1,CCOc1cc(C(C)(C)C)c(S(=O)(=O)N(C)C)cc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1C(=O)Cl.CS(=O)(=O)CCCN1CCNCC1>>CCOc1cc(C(C)(C)C)c(S(=O)(=O)N(C)C)cc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCN(CCCS(C)(=O)=O)CC1,,CCN(CC)CC,,Cl,Cl,val
US20050245503A1,N[C@H]1CCSC1=O.O=C(O)c1cnc(NNC(=S)N[C@H]2c3ccccc3CC[C@H]2c2ccccc2)c(Cl)c1>>O=C(NC1CCSC1=O)c1cnc(NNC(=S)N[C@H]2c3ccccc3CC[C@H]2c2ccccc2)c(Cl)c1,,CC(=O)N(C)C,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04550190,CCCc1c(O)ccc(C(C)=O)c1O.COC(=O)CCCOc1ccc2ccc(OCCCBr)c(C(C)=O)c2c1>>CCCc1c(OCCCOc2ccc3ccc(OCCCC(=O)OC)cc3c2C(C)=O)ccc(C(C)=O)c1O,,CC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],,val
US20040229900A1,COC(OC)N(C)C.N#Cc1ccc(CC(=O)c2ccc(C#N)cc2)cc1>>CN(C)/C=C(/C(=O)c1ccc(C#N)cc1)c1ccc(C#N)cc1,,COCCOC,,,,val
US20150315209A1,Cc1cnn(-c2ccncc2N2CCNCC2)c1.NCc1ccc(F)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cc1cnn(-c2ccncc2N2CCN(C(=O)NCc3ccc(F)cc3)CC2)c1,,C1CCOC1,O,CCN(C(C)C)C(C)C,,val
US20040106650A1,CCOP(=O)(Cc1ccc([N+](=O)[O-])cc1)OCC.O=Cc1cccc(F)c1>>O=[N+]([O-])c1ccc(/C=C/c2cccc(F)c2)cc1,,CN(C)C=O,,CCOC(C)=O,[H-].[Na+],val
US20160185785A1,CCOC(=O)C1CCC(OS(=O)(=O)c2ccc(C)cc2)CC1.c1cn[nH]c1>>CCOC(=O)C1CCC(n2cccn2)CC1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04698093,CCNC.CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)Cl)c(C(=O)OC)c1Cl>>CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)Cl)c(C(=O)OC)c1N(C)CC,,CN(C)C=O,,,,val
US07320993B1,Fc1ccc(C(=CCCCCCCBr)c2ccc(F)cc2)cc1>>Fc1ccc(C(CCCCCCCBr)c2ccc(F)cc2)cc1,[Pd],CCO,,[H][H],,val
US20100093730A1,O=C(O)CN1CCCC(c2ccccc2)(c2ccccc2)C1=O.c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>O=C(CN1CCCC(c2ccccc2)(c2ccccc2)C1=O)N1CCN(C(c2ccccc2)c2ccccc2)CC1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20110098429A1,CC(=O)c1cccc(-c2cccc(-c3ccccc3)c2OCc2ccccc2)c1.COc1ccccc1[Mg]Br>>COc1ccccc1C(C)(O)c1cccc(-c2cccc(-c3ccccc3)c2OCc2ccccc2)c1,,C1CCOC1,,[Cl-].[NH4+],,val
US20040220188A1,COC(=O)c1cc(I)ccc1N1NC(=O)CC1=O.O=Cc1ccco1>>COC(=O)c1cc(I)ccc1N1NC(=O)C(=Cc2ccco2)C1=O,c1ccncc1,CCO,,,,val
US20080176926A1,CS(=O)(=O)Cl.Cc1cc(CCC(=O)c2sc(C)c3c2CCC(C)(C)C3)cc(C)c1OCCCO>>Cc1cc(CCC(=O)c2sc(C)c3c2CCC(C)(C)C3)cc(C)c1OCCCOS(C)(=O)=O,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150259350A1,CN1CCNCC1.Cn1cc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(-c6ccc(C=O)c(F)c6)cn5)CCO4)c3n2)cn1>>CN1CCN(Cc2ccc(-c3cnc(N4CCO[C@H](Cn5nnc6ncc(-c7cnn(C)c7)nc65)C4)nc3)cc2F)CC1,,ClCCl,,CC(=O)O,O=C([O-])[O-].[K+].[K+],val
US20120022056A1,CNC(=O)c1ccc2c(N3CCN(C(=O)OC(C)(C)C)CC3)cccc2n1>>CNC(=O)c1ccc2c(N3CCNCC3)cccc2n1,,ClCCl,,,,val
US20080032972A1,CN1CCN(c2ccc(-c3cnc4c(c3)C(O)CCN4)cn2)CC1.Oc1c(F)ccc(F)c1Cl>>CN1CCN(c2ccc(-c3cnc4c(c3)C(Oc3c(F)ccc(F)c3Cl)CCN4)cn2)CC1,,CO,ClCCl,,,val
US20160039834A1,Cc1noc(C)c1-c1nc(-c2cccc(OCC(CN(C)C(=O)OC(C)(C)C)O[Si](C)(C)C(C)(C)C)c2)nc(NC2CCOCC2)c1C=O>>Cc1noc(C)c1-c1nc(-c2cccc(OCC(CN(C)C(=O)OC(C)(C)C)O[Si](C)(C)C(C)(C)C)c2)nc(NC2CCOCC2)c1CO,,C1CCOC1,,[BH4-].[Na+],,val
US20060189604A1,O=C(OC(=O)C(F)(F)F)C(F)(F)F.[O-][n+]1ccc2cccc(Br)c2c1>>O=c1[nH]ccc2cccc(Br)c12,,CN(C)C=O,,,,val
US20070117798A1,C[C@@H](O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)[C@H](NC(=O)OC(C)(C)C)c1cc(F)c(F)c(F)c1>>C[C@@H](O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)[C@H](N)c1cc(F)c(F)c(F)c1,,ClCCl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20010039285A1,COc1cccc(CCNC(=O)c2cccs2)c1>>COc1ccc2c(c1)CCN=C2c1cccs1,,N,,O=P(Cl)(Cl)Cl,,val
US05922646,COC(=O)Nc1ccc(C(=O)N(C)C)c(S(=O)(=O)NC(C)(C)C)c1>>COC(=O)Nc1ccc(C(=O)N(C)C)c(S(N)(=O)=O)c1,,O=C(O)C(F)(F)F,,,,val
US20120238587A1,Clc1ccc2ncnc(OC3CCOCC3)c2n1.SC1CCCCC1>>Clc1ccc2ncnc(SC3CCCCC3)c2n1,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US20070037846A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCOc1cccc2c1CCNC2>>CCCOc1cccc2c1CCN(C(=O)OC(C)(C)C)C2,,C1COCCO1,O,CCN(CC)CC,Cl,val
US20160083366A1,CC(=O)c1cc2cc(Cl)c(F)cc2[nH]c1=O.CC(C)(C)[S@@](N)=O>>C[C@H](N[S@@](=O)C(C)(C)C)c1cc2cc(Cl)c(F)cc2[nH]c1=O,,C1CCOC1,,[BH4-].[Na+],,val
US20110034455A1,CC(=O)Cl.O=C(NC1C2CC3CC(C2)CC1C3)N1CCC2(CC1)CNc1ccccc12>>CC(=O)N1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2ccccc21,,ClCCl,,CCN(C(C)C)C(C)C,,val
US04440779,CCOC(=O)C(=O)c1cc(COc2cccc(Cl)c2)c(C(=O)OCC)n1C>>Cn1c(C(=O)C(=O)O)cc(COc2cccc(Cl)c2)c1C(=O)O,,CCO,,Cl,[Na+].[OH-],val
US20090304734A1,CC(=O)OC(C)=O.CCOP(=O)(C[C@H]1O[C@H](COC(C)=O)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@@H]1N=[N+]=[N-])OCC>>CCOP(=O)(C[C@H]1O[C@H](COC(C)=O)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@@H]1NC(C)=O)OCC,Cl[Ni]Cl,CO,Cc1ccccc1,[BH4-].[Na+],,val
US20050026911A1,CNc1cc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)cc(C(=O)OC)c1>>CNc1cc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(O)C(C)(C)C)C2=O)cc(C(=O)OC)c1,,CO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20120041199A1,COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)CC3)nc(N)c2cc1OC.Cl>>COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)CC3)nc(N)c2cc1OC.Cl,,CC(C)=O,,,,val
US20100016279A1,FC(F)(F)c1nnc2ccc(Cl)nn12.Oc1ccc(N2CCNCC2)cc1>>Oc1ccc(N2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20090209561A1,CCCCn1c(N)cc(=O)[nH]c1=O.CCOC(=O)CCCBr>>CCCCn1c(N)cc(=O)n(CCCC(=O)OCC)c1=O,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],val
US20080234383A1,C#Cc1cc(CNC(=O)OC(C)(C)C)c(Cl)cc1NS(C)(=O)=O>>C#Cc1cc(CN)c(Cl)cc1NS(C)(=O)=O,O=C(O)C(F)(F)F,ClCCl,,,,val
US20050182045A1,CN1[C@H]2CCC[C@@H]1CC2.O=C([O-])OCCCl>>C1CC2CCC(C1)N2.Cl,,Cc1ccccc1,,O,,val
US20050288273A1,COC(=O)CCC#Cc1cc(F)cc([N+](=O)[O-])c1F>>COC(=O)CCCCc1cc(F)cc(N)c1F,[Pd],CO,,[H][H],,val
US20040044211A1,CN(C)CCO.CN1Cc2c(Cl)cc(Cl)cc2C(c2cccc(NC(=O)Oc3ccc([N+](=O)[O-])cc3)c2)C1.Cl>>CN(C)CCOC(=O)Nc1cccc(C2CN(C)Cc3c(Cl)cc(Cl)cc32)c1.Cl,,ClCCl,,O,O=C([O-])[O-].[K+].[K+],val
US20100273767A1,CCOC(=O)c1ccccc1-c1ccncc1C#N>>O=C1NCc2cnccc2-c2ccccc21,[Ni],CO,,N,,val
US20080207732A1,COC(=O)c1ccc(OCCO)cc1>>O=C(O)c1ccc(OCCO)cc1,,CO,,[Na+].[OH-],,val
US20050148645A1,CC(C)NC(=N)NC(=O)OCc1ccccc1.CSC1=NC(=O)C(=O)N1c1ccc(Cl)c(Cl)c1>>CC(C)NC(=NC(=O)OCc1ccccc1)N=C1NC(=O)C(=O)N1c1ccc(Cl)c(Cl)c1,,ClC(Cl)Cl,,,,val
US05792764,CSC1=NS(=O)(=O)c2cnccc2N1.NN>>NNC1=NS(=O)(=O)c2cnccc2N1,,CO,,O,O,val
US05101048,Ic1ccc(-c2ccc(I)cc2)cc1.N#C[Hg]C#N>>N#Cc1ccc(-c2ccc(I)cc2)cc1,,CN(C)C=O,,Cl,c1ccncc1,val
US20130345123A1,C=CCN(C(=O)C(NC(=O)OC(C)(C)C)C(C)(C)C=C)c1ccccc1>>CC(C)(C)OC(=O)NC1C(=O)N(c2ccccc2)CC=CC1(C)C,Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)C2=[Ru](Cl)(Cl)(=Cc2ccccc2)[P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)c(C)c1,ClCCCl,,,,val
US20150152113A1,CC(C)(C)OC(=O)N1CC=C(c2cc(F)cc(F)c2OC(F)F)CC1>>CC(C)(C)OC(=O)N1CCC(c2cc(F)cc(F)c2OC(F)F)CC1,O=[Pt]=O,CO,,[H][H],,val
US20100130538A1,CC(=O)CCl.Nc1cccc(Br)n1>>Cc1cn2c(Br)cccc2n1,,CCO,,,,val
US04963568,C=CCc1ccccc1.O=C(OO)c1ccccc1Cl>>c1ccc(CC2CO2)cc1,,CCOCC,ClCCl,,,val
US20100298566A1,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O.O=P(O)(O)O>>Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O.O=P([O-])([O-])[O-],,CO,,,,val
US20110144105A1,CC(C)(O)c1ccc(C(=CC2CCCC2)c2cc3cc(F)cnc3[nH]2)cc1>>CC(C)(O)c1ccc(C(CC2CCCC2)c2cc3cc(F)cnc3[nH]2)cc1,[Pd],CO,,,,val
US20060235030A1,C1CCCNCC1.Cc1ccc(C(=O)NC(C)C)cc1-c1nc(S(C)=O)nc2c1CNC(=O)N2c1c(F)cccc1F>>Cc1ccc(C(=O)NC(C)C)cc1-c1nc(N2CCCCCC2)nc2c1CNC(=O)N2c1c(F)cccc1F,,ClCCl,,,,val
US20150175623A1,CC1(C)OB(c2ccc(O)c(Cl)c2Br)OC1(C)C.CN1CCN(CCO)CC1>>CN1CCN(CCOc2ccc(B3OC(C)(C)C(C)(C)O3)c(Br)c2Cl)CC1,,Cc1ccccc1,,CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US04642308,CN(C)c1cccc(C(=O)O)c1.Nc1ccc2ccc(Cl)nc2n1>>CN(C)c1cccc(C(=O)Nc2ccc3ccc(Cl)nc3n2)c1,,O,,CC#N,,val
US20080214448A1,COc1ccccc1C#C[Si](C)(C)C>>C#Cc1ccccc1OC,,CO,O,[K+].[OH-],,val
US06172085B2,Cc1c(C)c2c(c(C)c1N)CC(C)(CBr)O2.O=C1NC(=O)c2ccccc21>>Cc1c(C)c2c(c(C)c1N)CC(C)(CN1C(=O)c3ccccc3C1=O)O2,,CC(=O)N(C)C,O,[K],,val
US20080009491A1,Nc1cccc(Cl)c1.O=C(Cl)c1nc(CCN2CCOCC2)n2ccccc12>>O=C(Nc1cccc(Cl)c1)c1nc(CCN2CCOCC2)n2ccccc12,,ClCCl,,CCN(CC)CC,Cl,val
US20070249608A1,CC1(C)CC=C(c2cc(C3(O)CCCCC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1.COCCN>>COCCNC1(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCC(C)(C)CC3)c2)CCCCC1,,CCOC(C)=O,ClCCl,O=S(Cl)Cl,,val
US20040072818A1,CC(N=C=O)c1ccccc1.Clc1ccc2c(N3CCNCC3)ccnc2c1>>CC(NC(=O)N1CCN(c2ccnc3cc(Cl)ccc23)CC1)c1ccccc1,,C1CCOC1,,CCCCCC,CCOC(C)=O,val
US04291049,COC(CNc1c(C)cccc1C)OC.O=C(Cl)c1ccccc1>>COC(CN(C(=O)c1ccccc1)c1c(C)cccc1C)OC,,CCOCC,,CCN(CC)CC,,val
US04591590,Cc1cccc(N2C(=O)c3ccccc3C2=O)n1.O=C1CCC(=O)N1Br>>O=C1c2ccccc2C(=O)N1c1cccc(CBr)n1,O=C(OOC(=O)c1ccccc1)c1ccccc1,ClC(Cl)Cl,,,,val
US20060052611A1,COc1cccc([Mg]Br)c1.COc1ccncc1.O=C(Cl)OCc1ccccc1>>O=C1C=CN(C(=O)OCc2ccccc2)C(c2ccccc2)C1,,C1CCOC1,,Cl,,val
US20090286811A1,COc1cccc(C=O)c1OCC(C)C.Cc1nc2sccn2c(=O)c1-c1ccc(OC(F)(F)F)cc1>>COc1cccc(/C=C/c2nc3sccn3c(=O)c2-c2ccc(OC(F)(F)F)cc2)c1OCC(C)C,,CCO,,C,C[O-].[Na+],val
US20020188120A1,CCCCOc1ccc(S(=O)(=O)C2(C(=O)OCC)CCN(Cc3ccc(OC)cc3)CC2)cc1>>CCCCOc1ccc(S(=O)(=O)C2(C(=O)O)CCN(Cc3ccc(OC)cc3)CC2)cc1,,CO,,[Na+].[OH-],,val
US20070238726A1,COc1ccc(Cn2nc(I)c3c(Oc4ccc(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)ccnc32)cc1.O=C(c1ccc(B(O)O)cc1)N1CCOCC1>>COc1ccc(Cn2nc(-c3ccc(C(=O)N4CCOCC4)cc3)c3c(Oc4ccc(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)ccnc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,COCCOC,,O=C([O-])[O-].[Na+].[Na+],,val
US20010039344A1,CCOC(=O)Cc1csc(NC(=O)C(CC2CCCC2)c2ccc(Cl)c(Cl)c2)n1>>O=C(O)Cc1csc(NC(=O)C(CC2CCCC2)c2ccc(Cl)c(Cl)c2)n1,,CCO,,[Na+].[OH-],,val
US05346920,CCI.NCCOc1ccc(Oc2cc(F)cc(F)c2)cc1Cl.O=C=S>>CCOC(=S)NCCOc1ccc(Oc2cc(F)cc(F)c2)cc1Cl,,C1CCOC1,,CCN(CC)CC,,val
US20040147748A1,CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)O)cc1.CSc1cnc(N)cn1>>CSc1cnc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)cc2)cn1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US05001137,CN(C)CCCl.O=C(C=Cc1ccccc1)c1cccnc1Oc1cc(Cl)c(Cl)cc1O>>CN(C)CCOc1cc(Cl)c(Cl)cc1Oc1ncccc1C(=O)C=Cc1ccccc1.Cl,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US04165377,CNC(=NC#N)NCCCCc1csc(NC(=N)N)n1.O=C(OC(=O)c1ccccc1)c1ccccc1>>CNC(=NC#N)NCCCCc1csc(NC(N)=NC(=O)c2ccccc2)n1,,O,c1ccncc1,,,val
US06645971B1,COc1cccc(C(=O)c2ccccc2N)c1.O=C(Cl)C(Cl)(Cl)Cl>>COc1cccc(C(=O)c2ccccc2NC(=O)C(Cl)(Cl)Cl)c1,,C1CCOC1,,CCN(CC)CC,O,val
US20080119457A1,COc1ccc2cc[nH]c2c1.N#Cc1ccc(F)cc1NC1CCC(O)CC1>>COc1ccc2ccn(-c3ccc(C#N)c(NC4CCC(O)CC4)c3)c2c1,,CCOC(C)=O,,[H-].[Na+],,val
US04198425,CC(=O)C=CCCc1ccc(OCc2ccccc2)cc1.CCOC(=O)CBr>>CCOC(=O)CC(C)(O)C=CCCc1ccc(OCc2ccccc2)cc1,[Zn],,,,,val
US20140336190A1,Cc1noc(C)c1-c1cc(Br)c(N)c(S(=O)(=O)NC2CCCC2)c1>>Cc1noc(C)c1-c1ccc(N)c(S(=O)(=O)NC2CCCC2)c1,[Pd],CO,ClCCl,,,val
US20060252757A1,COC(=O)Cc1ccc(C=O)cc1.Cc1cccc2c(-c3cccc(N)c3)c(-c3ccccc3)nnc12>>COC(=O)Cc1ccc(CNc2cccc(-c3c(-c4ccccc4)nnc4c(C)cccc34)c2)cc1,,CN(C)C=O,,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US20040157804A1,CCOC(=O)Oc1c2c(c(OC(c3ccccc3)c3ccccc3)c3ncn(Cc4ccccc4)c13)C(=O)N(Cc1ccc(F)cc1)C2=O>>O=C1c2c(c(O)c3c(ncn3Cc3ccccc3)c2OC(c2ccccc2)c2ccccc2)C(=O)N1Cc1ccc(F)cc1,CN(C)c1ccncc1,C1CCOC1,O,O=C([O-])[O-].[K+].[K+],,val
US20020052512A1,CN(C)CCCl.O=C(NCc1cccc(O)c1)c1ccc(C(=O)N[C@@H](CNC(=O)c2cccs2)C(=O)O)c(Cl)c1>>CN(C)CCOC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1ccc(C(=O)NCc2cccc(O)c2)cc1Cl,,CN(C)C=O,,Cl,[I-].[K+],val
US20160102059A1,COc1cc([N+](=O)[O-])ccc1S(=O)(=O)CCCN1CCOCC1>>COc1cc(N)ccc1S(=O)(=O)CCCN1CCOCC1,[Pd],CCO,,,,val
US20110098324A1,CCC(C)(C)N.CCOC(=O)CNC(=O)c1c(O)c(C(=O)OC)c(O)n(Cc2ccccc2C(F)(F)F)c1=O>>CCC(C)(C)NC(=O)c1c(O)c(C(=O)NCC(=O)O)c(=O)n(Cc2ccccc2C(F)(F)F)c1O,,ClC(Cl)Cl,,,,val
US20130023526A1,COc1cc(CNC(=O)c2cc(C(C)=O)nc(C)n2)ccc1F.O=Cc1cccnc1>>COc1cc(CNC(=O)c2cc(C(=O)C=Cc3cccnc3)nc(C)n2)ccc1F,,ClCCl,,O,[Al+3].[Cl-].[Cl-].[Cl-],val
US20150329506A1,CC(C)(C)[S@@](=O)N[C@@](C)(CCO)c1cc(Br)c(F)cc1F>>C[C@](N)(CCO)c1cc(Br)c(F)cc1F,,CO,,C1COCCO1,Cl,val
US20050272763A1,CCOC(=O)c1oc2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)cc2c1N.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)c1oc2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)cc2c1NC(=O)C(F)(F)F,,ClCCl,,CCN(CC)CC,,val
US20050020619A1,Nc1ccc(-c2csc3c(-c4ccc(OCc5ccccc5)cc4)cnc(N)c23)cc1>>Nc1ccc(-c2csc3c(-c4ccc(O)cc4)cnc(N)c23)cc1,,Br,CC(=O)O,,,val
US20020082260A1,O=C(O)C1CCCCCC1>>OCC1CCCCCC1,,C1CCOC1,,B,,val
US20150368246A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc(Cl)nc1I>>CC(C)(C)OC(=O)Nc1ccc(Cl)nc1I,CN(C)c1ccncc1,ClCCl,,,,val
US04748174,NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(O)CCC(=O)c1ccc(-c2ccccc2)cc1>>NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(O)CCC(=O)c1ccc(-c2ccccc2)cc1,,O,,,,val
US07223752B2,CCOC(=O)c1ccc(Br)cc1.Cc1cccc(B(O)O)c1>>CCOC(=O)c1ccc(-c2cccc(C)c2)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,O=C([O-])[O-].[Na+].[Na+],,val
US20060128685A1,CCOC(=O)c1cc(-c2ccccn2)n(-c2ccc(Br)cn2)n1.CO>>COc1ccc(-n2nc(C(=O)O)cc2-c2ccccn2)nc1,[Cu]Br,CO,Cc1ccccc1,O,C[O-].[Na+],val
US20090163463A1,CC(=O)Cc1ccc(Cl)c(S(=O)(=O)Cl)c1.N#Cc1cccc(N)c1>>CC(=O)Cc1ccc(Cl)c(S(=O)(=O)Nc2cccc(C#N)c2)c1,,C1COCCO1,,c1ccncc1,,val
US04343889,C=C(C)C(=O)Cl.CC(=O)C(C)=NO.O>>C=C(C)C(=O)O.CC(=O)C(C)=NO,,CCOCC,,CCN(CC)CC,,val
US05932599,CC(=O)Nc1ccc(S(=O)(=O)Nc2cc(C)nc(Br)c2)cc1>>Cc1cc(NS(=O)(=O)c2ccc(N)cc2)cc(Br)n1,,[Na+],[OH-],Cl,,val
US20080275094A1,CI.O=C1NC(=O)C(=Cc2cn(-c3ccccc3)nc2-c2cc(F)cc(F)c2)S1>>CN1C(=O)SC(=Cc2cn(-c3ccccc3)nc2-c2cc(F)cc(F)c2)C1=O,,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US20100087429A1,CC(=O)CCl.NC1=N[C@]2(CO1)c1cc(O)ccc1Oc1ccc(-c3cccnc3)cc12>>CC(=O)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cccnc3)ccc1O2,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040186292A1,CC(C)(C)OC(=O)N1CCC(O)(C(C(=O)O)c2ccccc2)CC1>>CC(C)(C)OC(=O)N1CCC(=C(C(=O)O)c2ccccc2)CC1,,CC(=O)OC(C)=O,,CC(=O)[O-].[Na+],,val
US20070027185A1,CC(C)(C)OC(=O)NCCOc1cc(N2CCOCC2)ccc1C(=O)O.Nc1cccnc1C(=O)Nc1ccc(Cl)cn1.O=C([O-])C(F)(F)F>>NCCOc1cc(N2CCOCC2)ccc1C(=O)Nc1cccnc1C(=O)Nc1ccc(Cl)cn1.O=C(O)C(F)(F)F,,CN(C)C=O,,,,val
US20040014751A1,COC(=O)/C=C/c1cc2c(=O)cc(Nc3ccccc3)n(-c3ccccc3)c2nc1C>>Cc1nc2c(cc1/C=C/C(=O)O)c(=O)cc(Nc1ccccc1)n2-c1ccccc1,,CC#N,O,[Na+].[OH-],,val
US20140275003A1,C1COCCN1.Clc1cc(Br)cnn1>>Clc1cc(N2CCOCC2)cnn1,,CN1CCCC1=O,,O=C([O-])[O-].[K+].[K+],,val
US20010053818A1,CCCCNc1cccc(O)c1.OCCBr>>CCCCN(CCO)c1cccc(O)c1,,CO,,O=C([O-])O.[Na+],,val
US20090270412A1,CC(=CBr)c1ccc(Cl)c(Cl)c1.Cc1ccc2[nH]c3c(c2c1)CCN(C)C3>>CC(=Cn1c2c(c3cc(C)ccc31)CCN(C)C2)c1ccc(Cl)c(Cl)c1,[Cu]I,CN(C)C=O,,O=C(O)[C@@H]1CCCN1,O=P([O-])([O-])[O-].[K+].[K+].[K+],val
US20050131017A1,CC[C@H](C)[C@@H](C(=O)N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCC1c2ccccc2-c2ccccc21)N1CCN(Cc2ccnc3ccccc23)C1=O>>CC[C@H](C)[C@@H](C(=O)N[C@@H](Cc1ccccc1)C[C@H](O)[C@@H](N)Cc1ccccc1)N1CCN(Cc2ccnc3ccccc23)C1=O,,CN(C)C=O,,CCNCC,,val
US20150315114A1,CC#C[Si](C)(C)C.CC(C)(C)[Si](C)(C)OC[C@H]1CO1>>CC(C)(C)[Si](C)(C)OC[C@H](O)CCC#C[Si](C)(C)C,I[Cu]I,COC(C)(C)C,,[Li]C(C)CC,,val
US20090018132A1,CN(C)C=O.FC(F)(F)c1cc(Br)c2[nH]ccc2c1>>O=Cc1cc(C(F)(F)F)cc2cc[nH]c12,,C1CCOC1,,[Li]CCCC,,val
US20100197679A1,Brc1cnc2c(c1)OCC=C2.CC(C)OB(OC(C)C)OC(C)C>>OB(O)c1cnc2c(c1)OCC=C2,,CCOCC,CCOCC,[Li]CCCC,,val
US20110172187A1,CCOC(=O)Cc1cc(NC(=O)C(F)(F)F)ccc1S(=O)(=O)Cl.Nc1ccc2c(c1)B(O)OC2>>CCOC(=O)Cc1cc(NC(=O)C(F)(F)F)ccc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2,,ClCCl,,c1ccncc1,,val
US20090069340A1,COc1ccc(Cl)cc1N1CCNCC1.Cn1c(CBr)c(OCC(F)(F)F)c(=O)n1-c1ccccc1>>COc1ccc(Cl)cc1N1CCN(Cc2c(OCC(F)(F)F)c(=O)n(-c3ccccc3)n2C)CC1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20100280011A1,CC(C)(C)OC(=O)NCCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(O)cc1.Cl.ClCCl>>Cl.Cl.NCCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(O)cc1,O,ClCCl,,,,val
US20100240692A1,CCN(CC)CCOc1cc(C)nc2c1ccc1cccnc12.O>>CCN(CC)CCOc1cc(C=O)nc2c1ccc1cccnc12,,O,,C1COCCO1,,val
US20070093496A1,BrBr.CN1CCn2cc(C(=O)NCc3ccc(F)c(Cl)c3)c(OCc3ccccc3)c2C1=O>>CN1CCn2c(Br)c(C(=O)NCc3ccc(F)c(Cl)c3)c(OCc3ccccc3)c2C1=O,,ClCCl,,O=C([O-])O.[Na+],,val
US20010006969A1,COC(=O)c1scc(C)c1N.NC(N)=O>>Cc1csc2c(=O)[nH]c(=O)[nH]c12,,CN(C)C=O,,,,val
US20070142389A1,CC(C)(C)OC(=O)N1CC[C@@H](c2ccccc2)[C@H](COS(C)(=O)=O)C1.CS(=O)(=O)c1ccccc1O>>CC(C)(C)OC(=O)N1CC[C@@H](c2ccccc2)[C@H](COc2ccccc2S(C)(=O)=O)C1,,CN(C)C=O,,,,val
US20120208817A1,CCOc1cc(C=O)cc([N+](=O)[O-])c1O.NC(N)=O.O=C(Cc1ccccc1)c1ccc(C(F)(F)F)cc1>>CCOc1cc(C2NC(=O)NC(c3ccc(C(F)(F)F)cc3)=C2c2ccccc2)cc([N+](=O)[O-])c1O,,CCO,,Cl,,val
US20150291573A1,CI.Cc1ccc(C(F)(F)F)cc1S(=O)(=O)[C@@H]1CCO[C@@H](c2ccc(Cl)cc2)C1>>CCc1ccc(C(F)(F)F)cc1S(=O)(=O)C1CCOC(c2ccc(Cl)cc2)C1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20020010169A1,COc1ccc(C2CC(c3c(O)cc(C)oc3=O)=NCCS2)c(OC)c1.O=C(Cl)Cl>>COc1ccc(C2C=C3c4c(cc(C)oc4=O)OC(=O)N3CCS2)c(OC)c1,CN(C)c1ccncc1,ClCCCl,,CCN(C(C)C)C(C)C,,val
US20130102585A1,O=C(Cl)C(=O)Cl.O=C(O)c1ccc(Oc2cccc(C(F)(F)F)c2)cc1>>O=C(Cl)c1ccc(Oc2cccc(C(F)(F)F)c2)cc1,CN(C)C=O,C1CCOC1,,,,val
US06444694B1,COC(=N)C=Cc1ccc(OC)c(OC)c1.Nc1ccc([N+](=O)[O-])cc1N>>COc1ccc(/C=C/c2nc3cc([N+](=O)[O-])ccc3[nH]2)cc1OC,,CO,,Cl,,val
US20110053933A1,CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN=C=NCCCN(C)C.CN1CCOCC1.Cl.On1nnc2ccccc21>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(Oc2ccc(Cl)cn2)CC1,,ClCCl,O,,,val
US20130123235A1,CCCC[Sn](/C=C\CN1CCCC1)(CCCC)CCCC.COC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2Br)ccc2c1OCc1occc1-2>>COC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2/C=C\CN2CCCC2)ccc2c1OCc1occc1-2,,C1COCCO1,CS(C)=O,,,val
US20040122001A1,C[C@@H]1CN(c2ccc(I)c3cc(F)ccc23)CCN1C(=O)OCc1ccccc1.O=S(=O)(c1ccccc1)N(F)S(=O)(=O)c1ccccc1>>C[C@@H]1CN(c2ccc(F)c3cc(F)ccc23)CCN1C(=O)OCc1ccccc1,,C1CCOC1,CCCCC,,,val
US20130005716A1,COc1ccc2cc(C(C)C(=O)O[C@H](Cc3c(Cl)cncc3Cl)c3ccc(OC)c(OC)c3)ccc2c1>>COc1ccc2cc([C@@H](C)C(=O)O[C@@H](Cc3c(Cl)cncc3Cl)c3ccc(OC)c(OC)c3)ccc2c1,,ClC(Cl)Cl,,CO,,val
US20060293392A1,C1=C(c2cccnc2)CCC2(C1)OCCO2>>c1cncc(C2CCC3(CC2)OCCO3)c1,[Pd],CCOC(C)=O,,,,val
US20030125334A1,CC(C)(C)OC(=O)N1CCN(c2cnc(Br)c(OCc3cccc(Cl)c3)n2)CC1.O=CO>>Clc1cccc(COc2nc(N3CCNCC3)cnc2Br)c1.O=CO,,O=CO,,,,val
US20070185197A1,COc1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>COc1ccc(Cc2ccccc2O[C@@H]2O[C@H](COC(c3ccccc3)(c3ccccc3)c3ccccc3)[C@@H](O)[C@H](O)[C@H]2O)cc1,CN(C)c1ccncc1,CN(C)C=O,,CCN(CC)CC,O,val
US05292760,Cc1ccsc1C(=O)Cc1ccccc1[N+](=O)[O-].NO>>Cc1ccsc1C(Cc1ccccc1[N+](=O)[O-])=NO,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20120046268A1,O=C(Cl)N1CCOCC1.O=C(NC1CNCC(c2ccc(C(F)(F)F)cc2)C1)c1ccccc1>>O=C(NC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1)c1ccccc1,,ClCCl,,CCN(CC)CC,O,val
US20100121022A1,C#CCBr.CC(C)(c1ccc(O)cc1)c1ccc(O)cc1>>C#CCOc1ccc(C(C)(C)c2ccc(O)cc2)cc1,,CN(C)C=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US06200981B1,COC(=O)CNCc1cccc(Cn2cc(C3c4ccccc4C=Cc4ccccc43)c(=O)[nH]c2=O)c1.O=C(Cl)OCc1ccccc1>>COC(=O)CN(Cc1cccc(Cn2cc(C3c4ccccc4C=Cc4ccccc43)c(=O)[nH]c2=O)c1)C(=O)OCc1ccccc1,,ClCCl,,CCN(CC)CC,,val
US20130018049A1,Cc1c(Br)ccc(O)c1N.O=C(Br)CBr>>Cc1c(Br)ccc2c1NC(=O)CO2,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US20110070317A1,CC(C)(C)OC(=O)N[C@@H]1CCCNC1.CCOc1cnc2[nH]cc(NC(=O)C3CC3)c2c1F>>CCOc1cnc2[nH]cc(NC(=O)C3CC3)c2c1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1,,CCCCO,,,,val
US20140309208A1,CCOc1c(OCC)c(=O)c1=O.CN(C)S(=O)(=O)c1cccc(N)c1O>>COc1c(Nc2cccc(S(=O)(=O)N(C)C)c2O)c(=O)c1=O,,CO,,,,val
US20160046624A1,CC(C)c1cccc(Oc2cnc3c(c2)c(=O)n(CCCOC2CCCCO2)c(=O)n3C)c1.O=Cc1ccccc1>>CC(C)c1cccc(Oc2cnc3c(c2C(O)c2ccccc2)c(=O)n(CCCOC2CCCCO2)c(=O)n3C)c1,,C1CCOC1,,CC(C)[N-]C(C)C.[Li+],,val
US20100113512A1,N#CCC(=O)c1cccc(Br)c1.NO>>Nc1cc(-c2cccc(Br)c2)no1,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20100160255A1,CC(C)N1C(=O)CC2(CCCN(C3CCN(C(=O)c4cc(-c5ccccn5)sc4NC(=O)OC(C)(C)C)CC3)C2)C1=O>>CC(C)N1C(=O)CC2(CCCN(C3CCN(C(=O)c4cc(-c5ccccn5)sc4N)CC3)C2)C1=O,,O=C(O)C(F)(F)F,,O=C([O-])[O-].[K+].[K+],,val
US20070197512A1,CC(C)C[C@H](Cl)C(=O)O.O=C(Cl)C(=O)Cl>>CC(C)C[C@H](Cl)C(=O)Cl,CN(C)C=O,ClCCl,,,,val
US20140350006A1,CCOC(=O)CC(=O)C(F)(F)F.Nc1cc(-c2ccccc2)n[nH]1>>Oc1cc(C(F)(F)F)c2c(-c3ccccc3)n[nH]c2n1,,CC(=O)O,O,,,val
US05405979,CC(C)=O.COc1ccc([C@H]2C[C@@]3(C)[C@@H](CC45OCCOC43OCCO5)[C@@H]3CC=C4CCCC[C@@H]4[C@@H]23)cc1>>COc1ccc([C@H]2C[C@]3(C)C(=O)CC[C@H]3[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@@H]23)cc1,,CC(C)=O,,Cl,O=C([O-])O.[Na+],val
US20100216788A1,CC(C)(C)OC(=O)NCCn1ccc2ncnc(Cl)c21.COC(=O)c1cccc(Oc2ccc(N)cc2Cl)c1>>COC(=O)c1cccc(Oc2ccc(Nc3ncnc4ccn(CCNC(=O)OC(C)(C)C)c34)cc2Cl)c1,,CC(C)O,,O=C([O-])O.[Na+],,val
US20110053902A1,COC(=O)C(C)(C)C(=O)N(O)C(C)(C)C>>CC(C)(C=O)C(=O)N(O)C(C)(C)C,,ClCCl,,CC(C)C[AlH]CC(C)C,,val
US20110053916A1,CC(=O)OC(C)=O.NCc1cccs1>>CC(=O)NCc1cccs1,CN(C)c1ccncc1,ClCCl,,O,,val
US06033601,CCCCCC(=O)Cl.Cc1ccc(S(=O)(=O)n2ccc3ccccc32)cc1>>CCCCCC(=O)c1cn(S(=O)(=O)c2ccc(C)cc2)c2ccccc12,,ClCCl,,[Al+3].[Cl-].[Cl-].[Cl-],,val
US20130338159A1,CSc1nccc(-c2cncnc2CC2CC2)n1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nccc(-c2cncnc2CC2CC2)n1,,ClCCl,,,,val
US20040122057A1,COC(C(=O)O)c1ccc(OCc2ccccc2)cc1>>COC(C(=O)O)c1ccc(O)cc1,[Pd],CCO,,,,val
US04377580,CCOC=C1C(=O)OC(C)(C)OC1=O.Nc1ncnc2ccccc12>>CC1(C)OC(=O)C(=CNc2ncnc3ccccc23)C(=O)O1,,CN(C)C=O,,,,val
US20040072892A1,CC(C)(C)OC(=O)N1Cc2cc(OCC(N)=O)ccc2C[C@H]1C(=O)N1C[C@@H](F)C[C@H]1C#N.Cl>>Cl.N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H]1Cc2ccc(OCC(N)=O)cc2CN1,,CCO,CCOC(C)=O,,,val
US03962376,COP(OC)OC.Cc1cc(C(C)(C)C)c(O)c(C)c1CCl>>COP(=O)(Cc1c(C)cc(C(C)(C)C)c(O)c1C)OC,,CCCCCCC,,,,val
US05587372,C=Cc1cc(OCOCCOC)c(OCOCCOC)c(Cl)c1Cl.O=C(OO)c1cccc(Cl)c1>>C=CC12C=C(OCOCCOC)C(OCOCCOC)=C(Cl)C1(Cl)O2,,C1CCCCC1,CCOC(C)=O,,,val
US20040006099A1,CC(C)(C)OC(=O)CNc1ccc(C#N)cc1NC(=O)CN(C(=O)OCc1ccccc1)c1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(N(Cc3nc4cc(C#N)ccc4n3CC(=O)O)C(=O)OCc3ccccc3)cc2)CC1,,CC(=O)O,,,,val
US20130059853A1,COc1c(OC(F)F)ccc(Br)c1O.NC(=O)c1ccc(CBr)cc1>>COc1c(OC(F)F)ccc(Br)c1OCc1ccc(C(N)=O)cc1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05102891,CN(c1ccncc1)n1ccc2cc(O)ccc21.O=C=NCc1ccccc1>>CN(c1ccncc1)n1ccc2cc(OC(=O)NCc3ccccc3)ccc21,,C1CCOC1,,O=C([O-])[O-].[K+].[K+],,val
US20140256767A1,Nc1ccccc1CN1C(=O)c2ccccc2C1=O.O=C1OC(=O)[C@H]2CCCC[C@@H]12>>O=C(O)[C@@H]1CCCC[C@@H]1C(=O)Nc1ccccc1CN1C(=O)c2ccccc2C1=O,,Cc1ccccc1C,,,,val
US20050222261A1,CCCCCCCN(Cc1ccc(F)cc1F)C(=O)CBr.COc1cc(CCO)ccc1O>>CCCCCCCN(Cc1ccc(F)cc1F)C(=O)COc1ccc(CCO)cc1OC,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04032525,CO.Cc1ccc(Sc2ccc(C)cc2CC(=O)O)cc1>>COC(=O)Cc1cc(C)ccc1Sc1ccc(C)cc1,,O,,O=S(=O)(O)O,,val
US04832736,Fc1cc(C(F)(F)F)cnc1F.Oc1ccc(O)cc1>>Oc1ccc(Oc2ncc(C(F)(F)F)cc2F)cc1,,CS(C)=O,,Cl,[K+].[OH-],val
US20140336153A1,CCOC(=O)/C=C/c1cnc2c(c1)CCC(=O)N2>>CCOC(=O)CCc1cnc2c(c1)CCC(=O)N2,[Pd],CO,,,,val
US20080275021A1,CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccccc1>>CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H]1CNC[C@H]1c1ccccc1,[Pd],CO,,O=C[O-].[NH4+],,val
US20100190763A1,CCNC(=O)c1cc(F)c(N2CCN(C(=O)OC(C)(C)C)CC2)cc1F.Cl>>CCNC(=O)c1cc(F)c(N2CCNCC2)cc1F.Cl,,C1COCCO1,CCOCC,,,val
US04282388,CI.O[C@H]1CCC[C@H]1OCc1ccccc1F>>CO[C@H]1CCC[C@H]1OCc1ccccc1F,,C1COCCO1,,CO,[H-].[Na+],val
US20020137755A1,CC(C)NC(=O)CN1CCNCC1.Nc1cc(Cl)ncn1>>CC(C)NC(=O)CN1CCN(c2cc(N)ncn2)CC1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20100216860A1,N#Cc1cccc(F)c1C#N.NN>>N#Cc1cccc2[nH]nc(N)c12,,CCO,,O,,val
US20110165118A1,CC(C)(C)OC(=O)c1[nH]c2ccc(C(F)(F)F)cc2c1-n1c(=O)c2cscc2n(C(=O)OC(C)(C)C)c1=O.Fc1ccc(F)c(CBr)c1>>CC(C)(C)OC(=O)c1c(-n2c(=O)c3cscc3n(C(=O)OC(C)(C)C)c2=O)c2cc(C(F)(F)F)ccc2n1Cc1cc(F)ccc1F,,C1CCOC1,CN(C)C=O,CCOC(C)=O,CC(C)(C)[O-].[K+],val
US20030045560A1,CCCCc1oc2ccccc2c1C(=O)NCc1ccc2c(-c3ccc(C)cc3)c(OCC#N)ccc2c1.[N-]=[N+]=[N-]>>CCCCc1oc2ccccc2c1C(=O)NCc1ccc2c(-c3ccc(C)cc3)c(OCc3nnn[nH]3)ccc2c1,,CN(C)C=O,O,[Cl-].[NH4+],,val
US20120046292A1,CCOC(=O)[C@@H]1CC[C@@H](Oc2cccc(F)c2)CC1>>O=C(O)[C@@H]1CC[C@@H](Oc2cccc(F)c2)CC1,,CCO,,C1CCOC1,[Na+].[OH-],val
US05478858,Cc1cc(N=C=S)c(C)c2[nH]cnc12.NCCN>>Cc1cc(NC(=S)NCCN)c(C)c2[nH]cnc12,,ClCCl,,CO,,val
US20020007045A1,CC(C)(C)C(=O)NCc1ccc(N)cc1.CC(C)NCC(O)c1ccc(Cl)c(Cl)c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN(CC(O)c1ccc(Cl)c(Cl)c1)C(=O)Nc1ccc(CNC(=O)C(C)(C)C)cc1,,CCOC(C)=O,,CCN(CC)CC,ClCCl,val
US20100035918A1,COC(=O)c1cccc(Cn2c(C)c(-c3ccc4ncnn4c3)n(-c3cccc(C)c3)c2=O)c1>>Cc1cccc(-n2c(-c3ccc4ncnn4c3)c(C)n(Cc3cccc(C(=O)O)c3)c2=O)c1,,O,,C1CCOC1,[Li+].[OH-],val
US20110212918A1,COC(=O)Nc1cnc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(CN)c1.N#CO[K]>>COC(=O)Nc1cnc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(CNC(N)=O)c1,,CC(=O)O,O,,,val
US20070060563A1,O=C(CBr)Oc1ccccc1.O=C(O[C@H]1CN2CCC1CC2)C(F)(c1ccccc1)c1ccccc1>>O=C(C[N+]12CCC(CC1)[C@@H](OC(=O)C(F)(c1ccccc1)c1ccccc1)C2)Oc1ccccc1.[Br-],,CS(C)=O,,,,val
US20160194332A1,C=C(C)C(=O)Cl.C=C1c2c(-c3cnc4ccccc4c3)c3c(N)ncnc3n2C[C@H]1N>>C=C(C)C(=O)N[C@@H]1Cn2c(c(-c3cnc4ccccc4c3)c3c(N)ncnc32)C1=C,,CC#N,O,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20070043080A1,CC(C)C(=O)Nc1cccc(C2CCN(CCCN)CC2)c1.O=C(Cl)Cc1ccc(F)cc1>>CC(C)C(=O)Nc1cccc(C2CCN(CCCNC(=O)Cc3ccc(F)cc3)CC2)c1,,C1CCOC1,,,,val
US20030195223A1,COC(=O)c1ccc(C)c(Br)c1.N#C[Cu]>>COC(=O)c1ccc(C)c(C#N)c1,,CCOC(C)=O,CN(C)C=O,,,val
US20110054178A1,CCOC(=O)N1CCCCC1=O.Cc1ccc(Sc2ccccc2Br)cc1>>CCOC(=O)N1CCC(O)(c2ccccc2Sc2ccc(C)cc2)CC1,,CCCCCCC,,C1CCOC1,Cl,val
US20060019974A1,N#Cc1ccc(Cl)cc1N.O=C(Cl)c1ccc(Br)cc1>>N#Cc1ccc(Cl)cc1NC(=O)c1ccc(Br)cc1,,C1CCOC1,,c1ccncc1,,val
US20120190677A1,CC1(C)CC(c2cccc(N3CCOCC3)c2)Nc2c(C(=O)O)cc(F)cc21.CS(N)(=O)=O>>CC1(C)CC(c2cccc(N3CCOCC3)c2)Nc2c(C(=O)NS(C)(=O)=O)cc(F)cc21,,CN(C)C=O,O,O=C(n1ccnc1)n1ccnc1,[H-].[Na+],val
US20040176435A1,N#Cc1cc2cccc(O[C@H](CCCl)c3ccccc3)c2s1.[I-]>>N#Cc1cc2cccc(O[C@H](CCI)c3ccccc3)c2s1,,CC(C)=O,,O,,val
US20150376136A1,CCOC(=O)C(C)(CC=C(C)C)C(=O)OCC.CNC(N)=O>>CC(C)=CCC1(C)C(=O)NC(=O)N(C)C1=O,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US05578627,CC(C)(C)OC(=O)NC(CO)COc1noc2ccc(N)cc12.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C>>CC(C)(C)OC(=O)Nc1ccc2onc(OCC(CO)NC(=O)OC(C)(C)C)c2c1,,CCOC(C)=O,,O,,val
US20010016594A1,CCCCc1ncc(CCl)n1Cc1ccccc1Cl.CCOC(=O)C(Cc1ccccc1)C(=O)OCC>>CCCCc1ncc(C(Cc2ccccc2)(C(=O)OCC)C(=O)OCC)n1Cc1ccccc1Cl,,CN(C)C=O,,Cl,[H-].[Na+],val
US20020052401A1,COc1ccc(S(=O)O)cc1.OB(O)c1cccc2ccccc12>>O=S(=O)(c1ccc(O)cc1)c1cccc2ccccc12,,CS(C)=O,,CCN(CC)CC,Cl,val
US20100240638A1,C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)c1ccccc1NCCCCN(C)CCCC(=O)OC.COc1ccc2c(O[C@@H]3C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C3)cc(-c3csc(NC(C)C)n3)nc2c1>>C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3csc(NC(C)C)n3)nc3cc(OC)ccc23)CN1C(=O)OC(C)(C)C)C(=O)NS(=O)(=O)c1ccccc1NCCCCN(C)CCCC(=O)OC,,ClCCl,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060135561A1,CC(C)(C)OC(=O)N1CC[C@H](NC(=O)OCc2ccccc2)[C@H](C(=O)N2CCSC2)C1>>O=C(N[C@H]1CCNC[C@H]1C(=O)N1CCSC1)OCc1ccccc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140296200A1,COCCCNC(=O)c1ccc(-n2ncc(C(=O)O)c2OC)nc1.O=C1CCC(=O)N1Br>>COCCCNC(=O)c1ccc(-n2ncc(Br)c2OC)nc1,,CN(C)C=O,O,O=C([O-])O.[Na+],,val
US20020007070A1,Cc1cccc(S(=O)(=O)Nc2ccc(C(C)C)n(CC(=O)OC(C)(C)C)c2=O)c1>>Cc1cccc(S(=O)(=O)Nc2ccc(C(C)C)n(CC(=O)O)c2=O)c1,,ClCCl,,O=C(O)C(F)(F)F,,val
US05389641,Cc1ccc(-c2cncnc2C#N)cc1.O=C1CCC(=O)N1Br>>N#Cc1ncncc1-c1ccc(CBr)cc1,,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20020103229A1,CC(=O)N1CCNCC1.COC(=O)CBr.NN>>CC(=O)N1CCN(CC(=O)NN)CC1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20090105253A1,CCN(CC)S(F)(F)F.CCNC(=O)c1ccc(-n2cc(C(=O)NC3CC3)nn2)c(OCCCCCCO)c1>>CCNC(=O)c1ccc(-n2cc(C(=O)NC3CC3)nn2)c(OCCCCCCF)c1,,ClCCl,,O=C([O-])O.[Na+],,val
US05185342,CO/N=C(/C(=O)OC)c1ccccc1Oc1cccc(C)c1.O=C1CCC(=O)N1Br>>CO/N=C(/C(=O)OC)c1ccccc1Oc1cccc(CBr)c1,,c1ccccc1,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US04438128,Cc1cccc(C)c1NCCCN.c1ccc(COc2ccc(OCC3CO3)cc2)cc1>>Cc1cccc(C)c1NCCCNCC(O)COc1ccc(O)cc1,,CC(C)O,,,,val
US20110218208A1,Cc1c(C)c(OCc2ccccc2)c(CCN)c(C)c1OCc1ccccc1.FC(F)(F)c1ccnc(Cl)c1>>CC1=C(C)C(=O)C(CCNc2cc(C(F)(F)F)ccn2)=C(C)C1=O,,CS(C)=O,,CCN(C(C)C)C(C)C,O,val
US20120142672A1,COC(=O)c1ccc(-c2cnc(C)o2)c(OC)c1>>COc1cc(C(=O)O)ccc1-c1cnc(C)o1,,CO,,Cl,[Na+].[OH-],val
US20050148627A1,CCOC(=O)C1=Cc2cc(Cl)c(CN=[N+]=[N-])cc2OC1C(F)(F)F>>CCOC(=O)C1=Cc2cc(Cl)c(CN)cc2OC1C(F)(F)F,[Pd],CCO,,,,val
US20150225422A1,COC(OC)N(C)C.NOS(=O)(=O)O.Nc1ncc(Cl)cc1I>>Clc1cc(I)c2ncnn2c1,,CCO,,c1ccncc1,,val
US05262390,COC(=O)C(C)Oc1cc(C)ccc1CO.O=S(Cl)Cl>>COC(=O)C(C)Oc1cc(C)ccc1CCl,c1ccncc1,ClCCl,,O,,val
US20110136843A1,CCOC(=O)c1cc(Cl)c(O)cc1O.COc1ccc(CCl)cc1>>CCOC(=O)c1cc(Cl)c(OCc2ccc(OC)cc2)cc1O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04006145,O=C1OCCN1CCCl.c1ccc(CN2CCNCC2)cc1>>O=C1OCCN1CCN1CCN(Cc2ccccc2)CC1,,Cc1ccccc1,,[I-].[K+],,val
US20100113450A1,CCOC(=O)CCCN(C)C1CCCCC1>>CN(CCCC(=O)O)C1CCCCC1,,C1CCOC1,,[Na+].[OH-],,val
US20100216986A1,CC(C)[Si](Oc1ccc(-c2ccc(CO)[se]2)cc1)(C(C)C)C(C)C>>OCc1ccc(-c2ccc(O)cc2)[se]1,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20150368240A1,C[Si](C)(C)C#Cc1ccc(C(=O)N2CCc3nc(NC4Cc5ccccc5C4)ncc3C2)cn1>>C#Cc1ccc(C(=O)N2CCc3nc(NC4Cc5ccccc5C4)ncc3C2)cn1,,C1CCOC1,,,,val
US20130245021A1,CC(C)(C)OC(=O)NCc1ccc(N)cc1.CCCCNc1ccc2ncc(C(=O)O)n2n1>>CCCCNc1ccc2ncc(C(=O)Nc3ccc(CNC(=O)OC(C)(C)C)cc3)n2n1,,CC#N,,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US05362878,CC(C)(C)c1ccc(S)cc1.CCCCCCC(Br)C(=O)OCC>>CCCCCCC(Sc1ccc(C(C)(C)C)cc1)C(=O)OCC,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US06326386B1,COCCN(C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1)C(C)C>>COCCN(C(=O)c1cc(Cl)cc(OCCNc2ccncc2)c1)C(C)C,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150064305A1,COC(=O)c1ccc(COc2ccc([N+](=O)[O-])cc2)cc1>>O=C(O)c1ccc(COc2ccc([N+](=O)[O-])cc2)cc1,,CC#N,,Cl,,val
US20100273853A1,CCOC(=O)Cc1ccc(N2C(=O)c3c(O)ccc(Cl)c3C2=O)cc1.O=S(=O)(OCC(F)F)C(F)(F)F>>CCOC(=O)Cc1ccc(N2C(=O)c3c(Cl)ccc(OCC(F)F)c3C2=O)cc1,,CN(C)C=O,,O,O=C([O-])[O-].[Na+].[Na+],val
US06127357,COc1ccccc1N1CCN(CCCN)CC1.Clc1ccccn1>>COc1ccccc1N1CCN(CCCNc2ccccn2)CC1,,ClCCl,,,,val
US20150087639A1,BrCCC12CC3CC(CC(C3)C1)C2.Nc1ccc([N+](=O)[O-])cc1F>>O=[N+]([O-])c1ccc(NCCC23CC4CC(CC(C4)C2)C3)c(F)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20020183337A1,CC(=O)OC(C)=O.CC(C)Cn1c(=O)n(C)c(=O)c2c(Sc3cccc(N)c3)c(Cc3cccc4ccccc34)sc21>>CC(=O)Nc1cccc(Sc2c(Cc3cccc4ccccc34)sc3c2c(=O)n(C)c(=O)n3CC(C)C)c1,,ClCCl,,CCN(CC)CC,,val
US20120252853A1,Cc1cc2cc(C#N)cc(F)c2n1S(=O)(=O)c1ccccc1>>Cc1cc2cc(C#N)cc(F)c2[nH]1,,C1CCOC1,,CO,[Na+].[OH-],val
US06281354B1,COc1cc2cc(C(=O)C3CCCN(COS(C)(=O)=O)c4c3cc(OCc3ccccc3)c3ccccc43)[nH]c2c(OC)c1OC>>COc1cc2cc(C(=O)C3CCCN(COS(C)(=O)=O)c4c3cc(O)c3ccccc43)[nH]c2c(OC)c1OC,[Pd],,,,,val
US20110178304A1,CC(O)c1ccc2c(c1)NC(=O)CC2>>CC(=O)c1ccc2c(c1)NC(=O)CC2,O=[Mn]=O,ClC(Cl)Cl,,,,val
US04353919,CCOc1nc2ccc(Cl)cc2s1>>O=c1[nH]c2ccc(Cl)cc2s1,,Cc1ccccc1,,Cl,,val
US20100204196A1,COc1cc2c(cc1[N+](=O)[O-])CN(CCF)CC2>>COc1cc2c(cc1N)CN(CCF)CC2,[Pd],CCOC(C)=O,CO,[H][H],,val
US20160184318A1,CC(C)(C)OC(=O)NC1CCNCC1.Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)O)n1>>Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCC(NC(=O)OC(C)(C)C)CC2)n1,,CCOC(C)=O,CN(C)C=O,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,CCN(C(C)C)C(C)C,val
US04376123,C=O.CNCCC(Oc1ccc2c(=O)c(-c3ccccc3)coc2c1)c1ccccc1>>CN(C)CCC(Oc1ccc2c(=O)c(-c3ccccc3)coc2c1)c1ccccc1,,O=CO,,,,val
US04973576,CCCCCC(=O)CC(=O)C(=O)OCC.NO>>CCCCCc1cc(C(=O)OCC)no1,,CCO,,Cl,O=C([O-])O.[Na+],val
US20140057945A1,COCCBr.O=C(Cn1nc(C(F)F)cc1C(F)F)N1CCC(c2nc(C3=NOC(c4c(O)cccc4Cl)C3)cs2)CC1>>COCCOc1cccc(Cl)c1C1CC(c2csc(C3CCN(C(=O)Cn4nc(C(F)F)cc4C(F)F)CC3)n2)=NO1,,CN(C)C=O,O,[I-].[K+],,val
US20070027178A1,NNc1cc([N+](=O)[O-])ccc1Br.O=C1CCNCC1>>O=[N+]([O-])c1ccc(Br)c2[nH]c3c(c12)CNCC3,,OCC(F)(F)F,,Cl,O,val
US20090105258A1,C=C[Sn](CCCC)(CCCC)CCCC.CC(C)(C)OC(=O)NCc1ccc(NS(C)(=O)=O)c(I)c1>>C=Cc1cc(CNC(=O)OC(C)(C)C)ccc1NS(C)(=O)=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20100204285A1,CCOC(=O)c1c(C)cn2ccsc12>>Cc1cn2ccsc2c1C(=O)O,,CCO,O,[Na+].[OH-],,val
US20160229816A1,CC(=O)OCCl.Cc1cc(-c2nccc(C(F)(F)F)n2)cc(-c2nn[nH]c2C#N)c1>>CC(=O)OCn1nc(C#N)c(-c2cc(C)cc(-c3nccc(C(F)(F)F)n3)c2)n1,,CN(C)C=O,,[H-].[Na+],,val
US20050081313A1,C1CCCNCC1.O=[N+]([O-])c1cnc(Cl)c([N+](=O)[O-])c1>>O=[N+]([O-])c1cnc(N2CCCCCC2)c([N+](=O)[O-])c1,,C1CCOC1,,,,val
US20140309208A1,O=c1[nH]c2cccc([N+](=O)[O-])c2o1>>Nc1cccc2[nH]c(=O)oc12,[Pd],CCO,,,,val
US06313137B1,Cc1cccc(C)c1CCl.Cc1nc2c(N)cc(C(N)=O)cn2c1C>>Cc1cccc(C)c1CNc1cc(C(N)=O)cn2c(C)c(C)nc12,,CC(C)=O,ClCCl,[I-].[K+],O=C([O-])[O-].[Na+].[Na+],val
US06326386B1,CC(C)(C)OC(=O)N(CCOc1cc(Cl)cc(C(=O)O)c1)c1ccncc1.CC(C)NCCS(=O)(=O)NCC(C)(C)C>>CC(C)N(CCS(=O)(=O)NCC(C)(C)C)C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20060106089A1,Nc1ccc(-c2ccncc2)cc1[N+](=O)[O-].O=S(=O)(Cl)c1ccc(Cl)cc1>>O=[N+]([O-])c1cc(-c2ccncc2)ccc1NS(=O)(=O)c1ccc(Cl)cc1,,CCOC(C)=O,c1ccncc1,,,val
US03931247,CC(=O)c1ccc(-c2ccc(Cl)c(Cl)c2)o1>>CC(O)c1ccc(-c2ccc(Cl)c(Cl)c2)o1,,CO,,[BH4-].[Na+],,val
US20060058320A1,CI.COc1ccc(CN(C(=O)OC(C)(C)C)c2nc(CO)cc3nc(-c4ccco4)nn23)cc1OC>>COCc1cc2nc(-c3ccco3)nn2c(N(Cc2ccc(OC)c(OC)c2)C(=O)OC(C)(C)C)n1,O=[Ag],,,,,val
US20110015073A1,CNc1c(S(C)(=O)=O)ccc(C(=O)CC(=O)C2CC2)c1C.COC(OC)N(C)C>>CNc1c(S(C)(=O)=O)ccc(C(=O)C(=CN(C)C)C(=O)C2CC2)c1C,,ClCCl,,,,val
US20030199550A1,CNC[C@@H]1CC[C@@H](CO)CC1.O=C(OCc1ccccc1)ON1C(=O)CCC1=O>>CN(C[C@@H]1CC[C@@H](CO)CC1)C(=O)OCc1ccccc1,,CO,,,,val
US20160024044A1,CCN(CC)S(F)(F)F.CNC[C@H](c1ccc2ccccc2c1)[C@H](O)c1ccccc1>>CNC[C@H](c1ccc2ccccc2c1)[C@@H](F)c1ccccc1,,ClCCl,,,,val
US04847303,CI.Oc1c(Br)cccc1C(F)(F)F>>Cc1cccc(C(F)(F)F)c1O,,C1CCOC1,CCCCCC,[Li]C(C)(C)C,,val
US20090054508A1,CC(C)(C)OC(=O)N1CCN(c2ccc(/C=C/c3n[nH]c4ccccc34)c([N+](=O)[O-])c2)CC1>>CC(C)(C)OC(=O)N1CCN(c2ccc(/C=C/c3n[nH]c4ccccc34)c(N)c2)CC1,[Fe],CCO,,O,,val
US20060004195A1,CC1(C)OC(=O)C(CC#CC(=O)c2ccc3c(c2)OCO3)(c2cccc(Cl)c2)O1.NNc1cc(Cl)ccc1Cl>>CC1(C)OC(=O)C(Cc2cc(-c3ccc4c(c3)OCO4)n(-c3cc(Cl)ccc3Cl)n2)(c2cccc(Cl)c2)O1,,CCO,,,,val
US20050250818A1,CC(C)CCO.COC(=O)c1ccc([C@H](C)NC(=O)c2cc(Cl)ccc2O)cc1>>COC(=O)c1ccc([C@H](C)NC(=O)c2cc(Cl)ccc2OCCC(C)C)cc1,,CC(C)CCO,,,,val
US06613942B1,COC(=O)c1ccc(C=O)c2ccccc12>>O=Cc1ccc(C(=O)O)c2ccccc12,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20160207930A1,C1CCOC1.C=CCBr.CN1CCCN(C)C1=O.Cc1ccc(C)c([C@H]2[C@@H]3CCC(=O)N3CCN2C(=O)OC(C)(C)C)c1>>C=CCC1(CC=C)C[C@H]2[C@@H](c3cc(C)ccc3C)N(C(=O)OC(C)(C)C)CCN2C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20140275084A1,Cn1cnc(-c2cc(C#N)ccn2)c1.[N-]=[N+]=[N-].[NH4+]>>Cn1cnc(-c2cc(-c3nn[nH]n3)ccn2)c1,,CN(C)C=O,,[Cl-].[Na+],,val
US20050282819A1,CC1(C)C(=O)C(C)(C)c2cc(C(Cl)CCN3CCN(c4noc5ccccc45)CC3)ccc21>>CC1(C)C(=O)C(C)(C)c2cc(CCCN3CCN(c4noc5ccccc45)CC3)ccc21,,Cc1ccccc1,,CC(C)(C#N)N=NC(C)(C)C#N,CCCC[SnH](CCCC)CCCC,val
US20100152190A1,CCOC(=O)c1ccc(CNC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(c3ccc(Cl)cc3F)[C@H]2c2cccc(Cl)c2F)nc1>>CC(C)(C)C[C@@H]1N[C@@H](C(=O)NCc2ccc(C(=O)O)cn2)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F,,C1CCOC1,O,[Li+].[OH-],,val
US05112977,O=C1c2ccc(F)cc2C(=O)c2cc3ccccc3cc21.OCCO>>O=C1c2ccc(OCCO)cc2C(=O)c2cc3ccccc3cc21,,O,,Cl,O=C([O-])[O-].[Cs+].[Cs+],val
US20100204214A1,NCCO.O=[N+]([O-])c1ccc(Br)cc1F>>O=[N+]([O-])c1ccc(Br)cc1NCCO,,CCCCO,,,,val
US20020107269A1,COC(=O)Cl.Nc1ccc(Cl)c(-c2nc3cc(Cl)ccc3o2)c1>>COC(=O)Nc1ccc(Cl)c(-c2nc3cc(Cl)ccc3o2)c1,,ClC(Cl)Cl,,c1ccncc1,,val
US20140378540A1,CC(C)(C)[Si](C)(C)Oc1ccc(Cc2cc(Br)ccc2Cl)cc1.CC1(C)O[C@@H]2O[C@@H](C=O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H]2O1>>CC1(C)O[C@@H]2O[C@@H](C(O)c3ccc(Cl)c(Cc4ccc(O[Si](C)(C)C(C)(C)C)cc4)c3)[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H]2O1,,C1CCOC1,,[Li]CCCC,,val
US20100152160A1,CN(C)c1cc2c(cc1Cl)N(C(=O)OC(C)(C)C)CC(C)(C(=O)N1CCC(C#N)(Cc3ccc(F)cc3)CC1)O2>>CN(C)c1cc2c(cc1Cl)NCC(C)(C(=O)N1CCC(C#N)(Cc3ccc(F)cc3)CC1)O2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20100240630A1,C=C(C)[C@@H]1CCC2(C#Cc3ccccc3C(=O)OC)CC[C@]3(C)C(CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12>>C=C(C)[C@@H]1CCC2(C#Cc3ccccc3C(=O)O)CC[C@]3(C)C(CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12,,C1CCOC1,CO,[Na+].[OH-],,val
US05130301,Cc1ccc(S(=O)(=O)Cl)cc1.c1cc2n(c1)-c1ccsc1CNC2>>Cc1ccc(S(=O)(=O)N2Cc3sccc3-n3cccc3C2)cc1,,O,c1ccncc1,,,val
US20080255152A1,NC(=O)c1ccc(Cl)nc1.Oc1ccc(CCNC2CCCC2O)cc1>>NC(=O)c1ccc(Oc2ccc(CCN[C@@H]3CCC[C@H]3O)cc2)nc1,,CN(C)C=O,Cc1ccccc1,O=C([O-])[O-].[K+].[K+],,val
US04171365,COc1ccc(OCCCCCCBr)c(Cl)c1.O=C(CC(=O)c1ccccc1)c1ccccc1>>COc1ccc(OCCCCCCC(C(=O)c2ccccc2)C(=O)c2ccccc2)c(Cl)c1,,CCC(C)=O,,[I-].[K+],,val
US20050203128A1,BrBr.CC(=O)O.CC1(CCO)CCOc2ccccc21>>CC(=O)OCCC1(C)CCOc2ccc(Br)cc21,,O,,O=C([O-])[O-].[K+].[K+],,val
US20090105253A1,CCNC(=O)c1ccc(-n2cc(C(=O)OCC)nn2)c(OCC)c1>>CCNC(=O)c1ccc(-n2cc(C(=O)O)nn2)c(OCC)c1,,CCO,,O,[Na+].[OH-],val
US20030216568A1,Cc1c(N2CCC(N)C(C)(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12.Cl>>Cc1c(N2CCC(N)C(C)(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12.Cl,,CCO,,CCOCC,,val
US06479524B1,Cc1cc(Br)ccc1N.O=[N+]([O-])c1ccccc1F>>Cc1cc(Br)ccc1Nc1ccccc1[N+](=O)[O-],,ClCCl,,[F-].[K+],,val
US20050165063A1,CCCN(CCC)CCCCNC(=O)c1ccc(CN(Cc2ncc[nH]2)C(=O)OC(C)(C)C)cc1.O=Cc1nccs1>>CCCN(CCC)CCCCNC(=O)c1ccc(CN(Cc2ncc[nH]2)Cc2nccs2)cc1,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20100029636A1,Cl.Nc1c(-c2ccc([N+](=O)[O-])cc2)cnc2c(-c3ccc(N4CCN(CCO)CC4)cc3)cnn12>>Cl.Nc1ccc(-c2cnc3c(-c4ccc(N5CCN(CCO)CC5)cc4)cnn3c2N)cc1,,CO,,,,val
US20120208804A1,CC1(CC2(c3ccccc3)CCN(C(C)(C)C#Cc3ccc(F)cc3)C(=O)O2)CO1>>CC(C)(O)CC1(c2ccccc2)CCN(C(C)(C)C#Cc2ccc(F)cc2)C(=O)O1,,C1CCOC1,CCOC(C)=O,O,,val
US20110178132A1,N#Cc1cc(Cl)ccn1.OB(O)c1cc(C(F)(F)F)ccc1Cl>>N#Cc1cc(-c2cc(C(F)(F)F)ccc2Cl)ccn1,,C1COCCO1,,[Cl-].[NH4+],O=C([O-])[O-].[K+].[K+],val
US20090054407A1,CN(C)C=O.Cc1ccc(C(=O)NC(C)(C)c2ccccc2)c(Cl)n1>>Cc1cc2c(c(Cl)n1)C(=O)N(C(C)(C)c1ccccc1)C2O,,C1CCOC1,,,,val
US04248620,CN1C(=O)C(=NC(Cl)C(Cl)C(Cl)(Cl)Cl)N(c2ccccc2F)C1=O.Nc1ccccc1F>>CN1C(=O)C(=NC(Nc2ccccc2F)C(Cl)C(Cl)(Cl)Cl)N(c2ccccc2F)C1=O,,CC#N,CCOCC,CCN(CC)CC,Cl,val
US20020028832A1,CC(C)(C)[Si](Oc1ccc(OC[C@@H](O)CNCCc2ccc(NC3CCN(C(=O)NCc4c(F)cccc4F)CC3)cc2)cc1)(c1ccccc1)c1ccccc1>>O=C(NCc1c(F)cccc1F)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1,,CO,ClC(Cl)Cl,,,val
US04835165,O=[N+]([O-])c1ccc(C2CCN(c3ccncc3)CC2)cc1>>Nc1ccc(C2CCN(c3ccncc3)CC2)cc1,[Pd],CO,,,,val
US20120040957A1,C1COCCN1.CC(C)(C)OC(=O)NC1CCN(CC2CS2)CC1>>CC(C)(C)OC(=O)NC1CCN(CC(S)CN2CCOCC2)CC1,,CCO,,,,val
US20080249175A1,O=[N+]([O-])c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1>>Nc1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1,[Pt],CCO,,,,val
US20130225524A1,Nc1cc(-c2ccco2)cc([N+](=O)[O-])c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=[N+]([O-])c1cc(NS(=O)(=O)C(F)(F)F)cc(-c2ccco2)c1,,ClCCl,,CCN(CC)CC,[Na+].[OH-],val
US20090029955A1,CC1(C)CCc2c(NCCc3ccccc3)nc(S)c(C#N)c2C1.NC(=O)CCl>>CC1(C)Cc2c(NCCc3ccccc3)nc3sc(C(N)=O)c(N)c3c2C1,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20140349998A1,O=C1CCC(=O)N1I.c1ccc(-c2ncnc3[nH]ccc23)cc1>>Ic1c[nH]c2ncnc(-c3ccccc3)c12,,CN(C)C=O,,,,val
US20080319005A1,CCOC(=O)Cc1ccc(Nc2ncnc(Cl)c2[N+](=O)[O-])cc1>>CCOC(=O)Cc1ccc(Nc2ncnc(Cl)c2N)cc1,[Ni],C1CCOC1,,,,val
US20030176447A1,COC(=O)C1COC(c2ccc(C(F)(F)F)cc2)=N1>>COC(=O)c1coc(-c2ccc(C(F)(F)F)cc2)n1,,Cc1ccccc1,,N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O,,val
US06069156,CCC(=O)c1c(CC)n(Cc2ccccc2Cl)c2cc(C#N)ccc12.C[Sn](C)(C)N=[N+]=[N-]>>CCC(=O)c1c(CC)n(Cc2ccccc2Cl)c2cc(-c3nnn[nH]3)ccc12,,Cc1ccccc1C,,Cl,,val
US06218538B1,N=C(N)c1ccccc1.O=C(COCCN1CCCCC1)CC(=O)OCCCc1ccccc1.O=Cc1ccc(Cl)c(Cl)c1>>O=C(OCCCc1ccccc1)C1=C(COCCN2CCCCC2)NC(c2ccccc2)=NC1c1ccc(Cl)c(Cl)c1,,CN(C)C=O,,Cl,CC(=O)[O-].[Na+],val
US05935956,Cc1ccc(N2N=C3c4ccncc4CCC3CC2=O)cc1>>Cc1ccc(N2CCC3CCc4cnccc4C3=N2)cc1,,O,,CO,,val
US20070161639A1,CCOC(=O)CC1CN(Cc2ccc(F)cc2)C(=O)c2c(OCc3ccccc3)c(=O)ccn21>>O=C1c2c(OCc3ccccc3)c(=O)ccn2C(CCO)CN1Cc1ccc(F)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110245205A1,CC(C)(C)OC(=O)N1CC(O)C1.Clc1ccnc(Cl)n1>>CC(C)(C)OC(=O)N1CC(Oc2ccnc(Cl)n2)C1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20110288067A1,CC(C)(C)S(=O)N=CC1CCCCC1.CC[Mg]Br>>CCC(NS(=O)C(C)(C)C)C1CCCCC1,,CCOCC,,CCOC(C)=O,[Cl-].[NH4+],val
US20060014945A1,O=C1NCCCC[C@H]1N(Cc1ccc([N+](=O)[O-])cc1)S(=O)(=O)c1ccc(Cl)cc1>>Nc1ccc(CN([C@@H]2CCCCNC2=O)S(=O)(=O)c2ccc(Cl)cc2)cc1,,CCO,,Cl[Sn]Cl,,val
US20030225268A1,CC(C)(C)OC(=O)N1C2CCC1CNC2.O=[N+]([O-])c1ccc(Br)cn1>>CC(C)(C)OC(=O)N1C2CCC1CN(c1ccc([N+](=O)[O-])nc1)C2,,Cc1ccccc1,,CCN(CC)CC,,val
US20040147741A1,CC(=O)OC(C)=O.CN(C)C1(c2ccccn2)CCC(NCCc2c[nH]c3ccccc23)CC1>>CC(=O)N(CCc1c[nH]c2ccccc12)C1CCC(c2ccccn2)(N(C)C)CC1,,c1ccncc1,,,,val
US20070149570A1,O=Cc1cc(Br)ccc1O.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>O=Cc1cc(Br)ccc1OCC(F)(F)F,,CN(C)C=O,,[H-].[Na+],,val
US20080249301A1,CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.C[C@@H](Oc1cc(-n2cnc3cc(Br)ccc32)sc1C(N)=O)c1ccccc1Cl>>C[C@@H](Oc1cc(-n2cnc3cc(B4OC(C)(C)C(C)(C)O4)ccc32)sc1C(N)=O)c1ccccc1Cl,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CCOC(C)=O,CN(C)C=O,CC(=O)[O-].[K+],,val
US04943569,COc1ccc(COC(=O)CC2C(C(C)O)C(=O)N2C(Cc2ccc(OC)cc2)Cc2ccc(OC)cc2)cc1.O=C(Cl)OCc1ccc([N+](=O)[O-])cc1>>COc1ccc(COC(=O)CC2C(C(C)OC(=O)OCc3ccc([N+](=O)[O-])cc3)C(=O)N2C(Cc2ccc(OC)cc2)Cc2ccc(OC)cc2)cc1,CN(C)c1ccncc1,ClCCl,,O,,val
US20160166560A1,CN(C(=O)n1cnc(-c2cccc(C(N)=O)c2)c1)C1CCN(c2ccc(O)cc2)CC1.Cl>>CN(C(=O)n1cnc(-c2cccc(C(N)=O)c2)c1)C1CCN(c2ccc(O)cc2)CC1.Cl,,CCOC(C)=O,CO,CCOCC,,val
US20130150339A1,O=S(=O)(Nc1ncns1)c1ccc2c(-c3ccc(Cl)cc3Br)cccc2c1.OB(O)c1ccncc1>>O=S(=O)(Nc1ncns1)c1ccc2c(-c3ccc(Cl)cc3-c3ccncc3)cccc2c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,O,,C1COCCO1,O=C([O-])[O-].[K+].[K+],val
US20150284378A1,Cl.O=C(Nc1cnsc1OC1CNC1)c1ccc(F)c(-c2c(F)cccc2F)n1>>NCC(CCl)Oc1sncc1NC(=O)c1ccc(F)c(-c2c(F)cccc2F)n1,,CO,,,,val
US20090035876A1,CC(=O)c1cc(C)ccc1[N+](=O)[O-].O=C1CCC(=O)N1Br>>CC(=O)c1cc(CBr)ccc1[N+](=O)[O-],,ClC(Cl)(Cl)Cl,,O=C(OOC(=O)c1ccccc1)c1ccccc1,,val
US20150011774A1,CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(N)=NO)cc1.Cc1oc(=O)oc1CCl>>CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2C(N)=NO)cc1,,CN(C)C=O,,O,[Na],val
US20060128664A1,BrBr.CC(=O)c1ccc(B(O)O)cc1F>>O=C(CBr)c1ccc(B(O)O)cc1F,,CO,,CC(=O)O,,val
US20020004514A1,COc1cc(-c2cccc(Cl)c2)c2cc(C(O)(c3ccc(Cl)nc3)c3cncn3C)ccc2n1.COc1ccc(CN)cc1>>COc1ccc(CNC(c2ccc(Cl)nc2)(c2ccc3[nH]c(=O)cc(-c4cccc(Cl)c4)c3c2)c2cncn2C)cc1,,C1CCOC1,Cc1ccccc1,O=S(Cl)Cl,,val
US20110070317A1,CN(C(=O)OC(C)(C)C)[C@@H]1CCCNC1.Nc1c[nH]c2ncc(Br)c(F)c12>>CN(C(=O)OC(C)(C)C)[C@@H]1CCCN(c2c(Br)cnc3[nH]cc(N)c23)C1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,,val
US20120028941A1,COC(=O)c1cc(F)c(C)c(-n2cc(Br)nc(Br)c2=O)c1.NC1(c2ccccc2OCc2ccccc2)CC1>>COC(=O)c1cc(F)c(C)c(-n2cc(Br)nc(NC3(c4ccccc4OCc4ccccc4)CC3)c2=O)c1,,C1COCCO1,Cl,CCN(C(C)C)C(C)C,,val
US20110071141A1,C[Si](C)(C)C#N.[O-][n+]1cccc2cc(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)ccc21>>N#Cc1ccc2cc(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)ccc2n1,,CCOC(C)=O,O,CC#N,CCN(CC)CC,val
US20070238771A1,CN(C(=O)OC(C)(C)C)C1CCNC1.O=C(O)c1cc2ccccc2[nH]1>>CN(C(=O)OC(C)(C)C)C1CCN(C(=O)c2cc3ccccc3[nH]2)C1,,C1CCOC1,,O=C(n1ccnc1)n1ccnc1,,val
US20090054407A1,COCCl.COc1ccc(C(=O)O)cc1O>>COCOc1cc(C(=O)O)ccc1OC,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20110003793A1,CC(C)(C)OC(=O)N1CCCc2[nH]c3cc(-n4ccc(-c5ccc(C(F)(F)F)nn5)cc4=O)ccc3c2C1.Cl>>Cl.O=c1cc(-c2ccc(C(F)(F)F)nn2)ccn1-c1ccc2c3c([nH]c2c1)CCCNC3,,CCOCC,CO,,,val
US20090181942A1,COc1cccc([C@H]2O[C@H](CCO)c3cccn3-c3ccc(Cl)cc32)c1OC>>COc1cccc([C@H]2O[C@H](CC=O)c3cccn3-c3ccc(Cl)cc32)c1OC,,ClCCl,,CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21,,val
US20060148858A1,CCOc1cc(O)ccc1CCC(=O)OC.CCOc1nn(-c2ccc(C(F)(F)F)cc2)cc1CCCO>>CCOc1cc(OCCCc2cn(-c3ccc(C(F)(F)F)cc3)nc2OCC)ccc1CCC(=O)O,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20090137557A1,COc1ccccc1-c1nc(C)c(Cl)c(=O)n1CCc1ccccc1>>Cc1nc(-c2ccccc2O)n(CCc2ccccc2)c(=O)c1Cl,,ClCCl,,BrB(Br)Br,,val
US20100249101A1,CC(=O)c1ccc(F)c(C(F)(F)F)c1.CNCCOC>>COCCN(C)c1ccc(C(C)=O)cc1C(F)(F)F,,CS(C)=O,O,O=C([O-])[O-].[K+].[K+],,val
US20140275031A1,C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CN(C5CCN(C(=O)Nc6ccncc6C(F)(F)F)CC5)C4)c3)ncnc21>>N#CCC1(n2cc(-c3ncnc4[nH]ccc34)cn2)CN(C2CCN(C(=O)Nc3ccncc3C(F)(F)F)CC2)C1,,ClCCl,,O=C(O)C(F)(F)F,,val
US08304419B2,N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CN)c2F)c1.O=C(O)c1csnn1>>N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CNC(=O)c3csnn3)c2F)c1,,CN(C)C=O,CO,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100317645A1,CCOC(=O)C(O)(c1ccc2c(c1)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2)C(C)C>>CC(C)C(O)(C(=O)O)c1ccc2c(c1)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2,,CCO,O,Cl,[Li+].[OH-],val
US06833421B1,COC(=O)c1cc(OCCCCCCCl)cc(C(=O)OC)c1>>OCc1cc(CO)cc(OCCCCCCCl)c1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110090450A1,BrCCCCOc1ccccc1.OB(O)c1cccc(F)c1F>>CCCCOc1ccc(-c2cccc(F)c2F)cc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,Cc1ccccc1,O,O=C([O-])[O-].[K+].[K+],,val
US20090221851A1,CC(=O)N/C(=C\C[PH](=O)CO)C(=O)O>>CC(=O)N[C@H](CC[PH](=O)CO)C(=O)O,,CO,,[H][H],,val
US20140200231A1,CC(C)(C)OC(=O)N1Cc2cnc(Cl)nc2C1.NC1Cc2ccccc2C1>>CC(C)(C)OC(=O)N1Cc2cnc(NC3Cc4ccccc4C3)nc2C1,,CN1CCCC1=O,,CCN(C(C)C)C(C)C,O,val
US04914128,COC=C(C(=O)OC)c1ccccc1CBr.Oc1ccccc1>>COC=C(C(=O)OC)c1ccccc1COc1ccccc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20140088124A1,CC(C)(C)OC(=O)N1CCC(COS(C)(=O)=O)CC1.COC(=O)c1ccc(O)cc1>>COC(=O)c1ccc(OCC2CCN(C(=O)OC(C)(C)C)CC2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20160009718A1,CCOC(=O)c1c(C)c(C(C)C2CCN(CC(C)(C)O)CC2)n2nc(C)ccc12>>Cc1ccc2c(C(=O)O)c(C)c(C(C)C3CCN(CC(C)(C)O)CC3)n2n1,,CO,O,Cl,[Na+].[OH-],val
US20110112122A1,CC(C)(C)OC(=O)c1c(Br)cc(OCc2ccccc2)c2[nH]c3c(c12)C1CCC(C3)N1.CI>>Cn1c2c(c3c(C(=O)OC(C)(C)C)c(Br)cc(OCc4ccccc4)c31)C1CCC(C2)N1,,CN(C)C=O,,[H-].[Na+],,val
US05993780,CC(=O)OCCN(C(=O)COC(C)=O)c1c(I)c(COC(C)=O)c(I)c(C(=O)NCC(COC(C)=O)OC(C)=O)c1I>>O=C(NCC(O)CO)c1c(I)c(CO)c(I)c(N(CCO)C(=O)CO)c1I,,CO,,[Na+].[OH-],,val
US06147097,CC(C)c1nc(CO)n(Cc2ccc[nH]c2=O)c1Sc1cc(Cl)cc(Cl)c1.O=C=NC(=O)C(Cl)(Cl)Cl>>CC(C)c1nc(COC(N)=O)n(Cc2ccc[nH]c2=O)c1Sc1cc(Cl)cc(Cl)c1,,C1CCOC1,CO,CCN(CC)CC,O,val
US20130059834A1,CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3n[nH]c4ccc(OC(F)F)cc34)nc12.CC(C)(C)OC(=O)N1CCC(COS(C)(=O)=O)C1>>CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CC4CCN(C(=O)OC(C)(C)C)C4)c4ccc(OC(F)F)cc34)nc12,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100056796A1,CC(C)(C)OC(=O)Nc1ccc(Br)nc1[N+](=O)[O-].CI>>CN(C(=O)OC(C)(C)C)c1ccc(Br)nc1[N+](=O)[O-],,CN(C)C=O,,[H-].[Na+],,val
US20030229226A1,CCN(CC)CC.ClCCl.N#CBr.N#CN.O=S(=O)(Cl)c1ccccc1>>N#CN1CCC(CNS(=O)(=O)c2ccccc2)C1,,CCOC(C)=O,ClCCl,O=C(O)C(F)(F)F,,val
US05763489,CCOC(=O)CBr.O=c1ccc(C(c2ccccc2)c2ccccc2)nn1CC1CCc2c(O)cccc2C1>>CCOC(=O)COc1cccc2c1CCC(Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US20030166639A1,CCOc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3cc(C)nc(CC)c3)c2)cc1C(F)(F)F>>CCOc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3cc(C)nc(CC)c3)c1)=N2,,ClCCl,,O=C(O)C(F)(F)F,,val
US20070135367A1,C1CCNCC1.O=[N+]([O-])c1cc(F)ccc1F>>O=[N+]([O-])c1cc(F)ccc1N1CCCCC1,,O,,CN(C)C=O,,val
US20110077243A1,CC(C)Oc1nccs1.O=C1CCC(=O)N1Br>>CCOc1ncc(Br)s1,,CN(C)C=O,,CCCCCC,CCOC(C)=O,val
US20090042967A1,C[C@H]1[C@H](O)C(F)(F)C(=O)N1c1cccc(Cl)c1.O=C1CCC(=O)N1I>>C[C@H]1[C@H](O)C(F)(F)C(=O)N1c1ccc(I)c(Cl)c1,O=S(=O)(O)O,CC(=O)O,,,,val
US20150080549A1,CN(C(=O)OC(C)(C)C)[C@@H](CSSC(C)(C)C)C(=O)O.N#CCBr>>CN(C(=O)OC(C)(C)C)[C@@H](CSSC(C)(C)C)C(=O)OCC#N,,CN(C)C=O,,CCN(C(C)C)C(C)C,[Cl-].[NH4+],val
US08350090B1,COc1cccc(CC(=O)c2ccco2)c1>>COc1cccc(CC(O)c2ccco2)c1,,CO,,[BH4-].[Na+],,val
US20150197511A1,O=[N+]([O-])c1cc(N2CCC(F)CC2)cc(C(F)(F)F)c1>>Nc1cc(N2CCC(F)CC2)cc(C(F)(F)F)c1,[Pd],CO,,,,val
US20110201609A1,CCOC(=O)CSC1=C/C(=N\S(=O)(=O)c2cccs2)c2ccccc2C1=O.Cc1ccc(S(N)(=O)=O)cc1>>CCOC(=O)CSC1=CC(=NS(=O)(=O)c2ccc(C)cc2)c2ccccc2C1=O,Cl[Ti](Cl)(Cl)Cl,C1CCOC1,,,,val
US20010003782A1,COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2C3=CC=C4C(C)(C)[C@@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C>>COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2C3=CC=C4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C,,C1CCOC1,,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],val
US20100152197A1,CC(C)(C)OC(=O)N1CCNCC1.CCc1nc(NC(=O)Oc2ccccc2)sc1Cl>>CCc1nc(NC(=O)N2CCNCC2)sc1Cl,,ClCCl,,,,val
US20060074084A1,CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3[nH]c(C(=O)O)c(-c4ccc(Cl)cc4)c3c2)cc1.CN(C)CCN>>CN(C)CCNC(=O)c1[nH]c2ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc2c1-c1ccc(Cl)cc1,,CO,ClCCl,,,val
US20150018547A1,CCOC(=O)Cc1csc2cc(O)ccc12.ClCc1ccc(Cl)cc1Cl>>CCOC(=O)Cc1csc2cc(OCc3ccc(Cl)cc3Cl)ccc12,,CCOC(C)=O,,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20160264548A1,C=CC(=O)Cl.NC(=O)c1cc(NC2CCNCC2)cnc1Oc1ccc(Oc2cccc(F)c2)cc1>>C=CC(=O)N1CCC(Nc2cnc(Oc3ccc(Oc4cccc(F)c4)cc3)c(C(N)=O)c2)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US05773428,BrCc1ccccc1.CCC(O)C(=O)O>>CCC(O)C(=O)OCc1ccccc1,,CN(C)C=O,,[Na],,val
US20050020606A1,Cc1cc(OCC(F)(F)F)c(N)c(OCC(F)(F)F)n1.O=C(Br)CBr>>Cc1cc(OCC(F)(F)F)c(NC(=O)CBr)c(OCC(F)(F)F)n1,,ClCCl,O,CN(C)c1ccccc1,,val
US20030003049A1,CS(=O)(=O)OCCc1ccc(OCc2ccccc2)c(-c2ccc(F)cc2)c1>>OCCc1ccc(OCc2ccccc2)c(-c2ccc(F)cc2)c1,,CO,O,Cl,[Na+].[OH-],val
US20140135318A1,CC(=O)N1CCc2cc(S(N)(=O)=O)ccc21>>NS(=O)(=O)c1ccc2c(c1)CCN2,,CO,,Cl,,val
US20150133402A1,COc1ccc(COc2cccc(C=O)c2Br)cc1>>COc1ccc(COc2cccc(CO)c2Br)cc1,,CCO,,[BH4-].[Na+],,val
US20080207630A1,CC(C)[C@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(=O)N1CCN(C(=O)OCc2ccccc2)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21>>CC(C)[C@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(=O)N1CCNC[C@H]1C(=O)N[C@@H]1CCCc2ccccc21,[Pd],CO,,,,val
US20110300165A1,CC(C)(C)C#Cc1ccccc1.COC(=O)C(C(=O)OC)[N+](=O)[O-]>>COC(=O)c1noc(-c2ccccc2)c1C(C)(C)C,,Cc1cc(C)cc(C)c1,,,,val
US20090062223A1,CC(C)C(=O)OCOC(=O)Nc1cc2c(=O)[nH]ncc3nn(C4OC(C(C)(C)O[SiH2]C(C)(C)C)C(OC(=O)CNC(=O)C(NC(=O)OCc5ccccc5)C(C)C)C4(C)O)cc1c32>>CC(C)C(=O)OCOC(=O)Nc1cc2c(=O)[nH]ncc3nn(C4OC(CO)C(OC(=O)CNC(=O)C(NC(=O)OCc5ccccc5)C(C)C)C4(C)O)cc1c32,,C1CCOC1,,,,val
US20150353533A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@H]1CCc2cc(Br)ccc2NC1=O>>CC(C)(C)OC(=O)N[C@H]1CCc2cc(Br)ccc2NC1=O,,ClCCl,O,CCN(CC)CC,,val
US20100324041A1,C=O.CC(C)NC[C@@H](C(=O)N1CCN(c2c(-c3ccccc3)cnc3[nH]ccc23)CC1)c1ccc(Cl)cc1>>CC(C)N(C)C[C@@H](C(=O)N1CCN(c2c(-c3ccccc3)cnc3[nH]ccc23)CC1)c1ccc(Cl)cc1,,CO,,[BH3-]C#N.[Na+],,val
US20100022484A1,CC(=O)CC(C)=O.CC(N)=CC(=O)OCC(F)(F)F.Cc1cc(=O)c2cccc(C=O)c2o1>>CC(=O)C1=C(C)NC(C)=C(C(=O)OCC(F)(F)F)C1c1cccc2c(=O)cc(C)oc12,,CC(C)O,,CC(=O)O,,val
US05530015,CC(C)(C)OCl.CC(C)Oc1ccc(C(C)(C)c2ccc(O)cc2)cc1>>CC(C)Oc1ccc(C(C)(C)c2ccc(O)c(Cl)c2)cc1,,ClC(Cl)(Cl)Cl,,,,val
US06906089B2,Cc1cccc(CC(=O)c2ccc3nsnc3c2)n1.O>>Cc1cccc(C(=O)C(=O)c2ccc3nsnc3c2)n1,,CS(C)=O,O,Br,O=C([O-])O.[Na+],val
US04052407,CCCCCC(=O)/C=C/c1sc(C)nc1CCCCCCC(=O)O>>CCCCCC(O)/C=C/c1sc(C)nc1CCCCCCC(=O)O,,CC(C)O,O,Cl,[BH4-].[Na+],val
US20070213371A1,Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)ccc2C(O)C2CCCCC2)n1.O=C1CCC(=O)N1Br>>Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)ccc2C(Br)C2CCCCC2)n1,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US05773624,CCOC(=O)C(C#N)=NO.FCBr>>CCOC(=O)C(C#N)=NOCF,,CN(C)C=O,CS(C)=O,O=C([O-])[O-].[K+].[K+],,val
US20090221587A1,Cc1c([N+](=O)[O-])c(C(=O)O)cc2nc(C(F)(F)F)ccc12>>Cc1c(N)c(C(=O)O)cc2nc(C(F)(F)F)ccc12,[Ni],CCO,,,,val
US20050153959A1,Cc1cc(CC(O)c2cccc(Br)n2)cc2cn(COCC[Si](C)(C)C)nc12.O=C1NC(=O)c2ccccc21>>Cc1cc(CC(c2cccc(Br)n2)N2C(=O)c3ccccc3C2=O)cc2cn(COCC[Si](C)(C)C)nc12,,CCCCCC,ClCCl,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20080114006A1,CCOC(=O)c1cnc(Cl)cc1Nc1ccccc1>>OCc1cnc(Cl)cc1Nc1ccccc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US05106985,NO.O=C(Cc1ccc(Cl)cc1)C(F)(F)F>>ON=C(Cc1ccc(Cl)cc1)C(F)(F)F,,CCO,O,Cl,CC(=O)[O-].[Na+],val
US20020103226A1,COc1ccc(OCC#N)cc1.NO>>COc1ccc(OCC(N)=NO)cc1,,CO,,Cl,CC(=O)[O-].[Na+],val
US20110218192A1,C[Si](C)(C)N=C=N[Si](C)(C)C.O=C1CC(c2ccccn2)Oc2ccc(Br)cc21>>N#CN=C1CC(c2ccccn2)Oc2ccc(Br)cc21,Cl[Ti](Cl)(Cl)Cl,ClCCl,,,,val
US20050107364A1,CC(C/C=C/C1CCCCC1)(C(=O)OCc1ccccc1)c1ccccc1>>CC(CCCC1CCCCC1)(C(=O)O)c1ccccc1,[Pd],CCOC(C)=O,,,,val
US20100004312A1,CCSCCOc1cc(C)c(-c2cccc(CO)c2)c(C)c1.COC(=O)C[C@@H]1COc2cc(O)ccc21>>CCSCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)OC)c2)c(C)c1,,CCCCCC,Cc1ccccc1,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20080293749A1,CCS(=O)(=O)c1cccc([N+](=O)[O-])c1C#N>>CCS(=O)(=O)c1cccc(N)c1C(N)=O,[Ni],CCO,CCOC(C)=O,NN,O,val
US05985306,COc1ccc2c(c1)OCC(c1ccccc1)=C2c1ccc(O)cc1>>COc1ccc2c(c1)OC[C@@H](c1ccccc1)[C@H]2c1ccc(O)cc1,[Pd],CCO,,,,val
US20140187553A1,CCCC[Sn](CCCC)(CCCC)c1nccc(Cl)n1.Cc1ccc(S(=O)(=O)n2cc(I)c3cc(-c4nnc(NC(C)C)o4)ccc32)cc1>>Cc1ccc(S(=O)(=O)n2cc(-c3nccc(Cl)n3)c3cc(-c4nnc(NC(C)C)o4)ccc32)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,ClCCl,,,val
US20090093483A1,COc1ccc2c(c1)C(O)=C(C(=O)NCC(=O)OC(C)(C)C)C(=O)C21CCOCC1>>COc1ccc2c(c1)C(O)=C(C(=O)NCC(=O)O)C(=O)C21CCOCC1,,O=C(O)C(F)(F)F,,,,val
US05955607,CCS(=O)(=O)N(CCCCC(=O)OC)C1CC(C)(C)Oc2ccc(C)cc21>>CCS(=O)(=O)N(CCCCC(=O)O)C1CC(C)(C)Oc2ccc(C)cc21,,CO,,Cl,[K+].[OH-],val
US20090298823A1,CC(=O)N1CCN(c2ccc(N)cc2)CC1.Cc1ccc(S(=O)(=O)n2ccc3c(N4CCC(CNC(=O)OC(C)(C)C)CC4)nc(Cl)nc32)cc1>>CC(=O)N1CCN(c2ccc(Nc3nc(N4CCC(CN)CC4)c4ccn(S(=O)(=O)c5ccc(C)cc5)c4n3)cc2)CC1,,CCCCO,,C[Si](C)(C)Cl,,val
US20130131050A1,CCSc1nc2[nH]c(=O)ccc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1.CI>>CCSc1nc2c(ccc(=O)n2C)c(=O)n1-c1ccc(OCC(F)(F)F)cc1,,CN(C)C=O,,Cl,[H-].[Na+],val
US20120329847A1,CC(=O)C1CCC(C)=CC1(C)C.CON>>CON=C(C)C1CCC(C)=CC1(C)C,,CO,,Cl,c1ccncc1,val
US05789405,COC1C(OC(=O)NC2CCCCC2)CCC2(CO2)C1C1(C)OC1CC=C(C)C.O=[O+][O-]>>COC1C(OC(=O)NC2CCCCC2)CCC2(CO2)C1C1(C)OC1CCO,,CO,ClCCl,,,val
US20070244103A1,CCOC(=O)C=O.Cc1cccc(N)c1N>>Cc1cccc2ncc(=O)[nH]c12,,CCO,,,,val
US20110212918A1,CC(C)(C)C(=O)Cl.CCOC(=O)Nc1cc(O)ccc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2>>CCOC(=O)Nc1cc(OC(=O)C(C)(C)C)ccc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2,,c1ccncc1,,O,,val
US20030229053A1,BrCc1ccc(I)cc1.COC(=O)C(Cc1ccccc1)NS(=O)(=O)c1c(C)cc(OC)c(C)c1C>>COC(=O)C(Cc1ccccc1)N(Cc1ccc(I)cc1)S(=O)(=O)c1c(C)cc(OC)c(C)c1C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20040010009A1,CCOC(=O)c1cc([N+](=O)[O-])ccc1OC1CCN(C(=O)OC(C)(C)C)CC1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])cc2C(=O)O)CC1,,CCO,,[K+].[OH-],,val
US20070203161A1,C#CCOc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1.CCC(=O)OC(=O)CC>>C#CCOc1ccc(Nc2nc(Nc3ccc(C)c(S(=O)(=O)NC(=O)CC)c3)ncc2F)cc1,CN(C)c1ccncc1,C1CCOC1,CCOC(C)=O,CCN(CC)CC,,val
US06642389B2,CC(C)NC(C)C.CCOC(=O)CN=C(c1ccccc1)c1ccccc1.Cc1oc(-c2ccccc2)nc1CCOc1ccc(CBr)c2ccccc12.[Li]CCCC>>CC(C)[N-]C(C)C.CCOC(=O)C(Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)c2ccccc12)N=C(c1ccccc1)c1ccccc1.[Li+],,C1CCOC1,CN1CCCN(C)C1=O,O=C=O,,val
US05929266,C=CCSc1ccccc1.CC[Al](CC)CC>>CCC(C)CSc1ccccc1,,O,,CCCCCC,,val
US20120208817A1,CCOc1cc(C=O)cc([N+](=O)[O-])c1O.COc1ccc(C(=O)Cc2ccccc2)cc1F.NC(N)=O>>CCOc1cc(C2NC(=O)NC(c3ccc(OC)c(F)c3)=C2c2ccccc2)cc([N+](=O)[O-])c1O,,CCO,,Cl,,val
US04584304,CC(C)CON=C[C@H]1[C@@H](C(=O)O)C1(C)C.OCc1cccc(Oc2ccccc2)n1>>CC(C)CON=CC1C(C(=O)OCc2cccc(Oc3ccccc3)n2)C1(C)C,CN(C)c1ccncc1,CCCCCC,ClCCl,,,val
US20080293940A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc(C(=O)O)cc1I>>Cc1ccc(C(=O)OC(C)(C)C)cc1I,CN(C)c1ccncc1,CC(C)(C)O,,,,val
US05106921,NCCO.O=C(Oc1ccccc1)c1ccc(O)cc1>>O=C(NCCO)c1ccc(O)cc1,,ClC(Cl)Cl,,,,val
US06174895B1,C1CCOC1.CCCCCC.Fc1ccccn1.[Li]CCCC>>O=C(CCc1ccccc1)c1cccnc1F,,CCCCCC,,CC(C)NC(C)C,,val
US20060025400A1,Nc1ccc(CCC(=O)O)cc1>>Nc1ccc(CCCO)cc1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20080051416A1,CC(C)(C)CNC(=O)c1ccc(Br)c(C(=O)O)c1.OCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)CNC(=O)c1ccc(Br)c(NC(=O)OCc2ccccc2)c1,,Cc1ccccc1,,CCN(CC)CC,,val
US20030040520A1,CC(C)(C)OC(=O)N1CCC(COS(C)(=O)=O)CC1.c1c[nH]cn1>>CC(C)(C)OC(=O)N1CCC(Cn2ccnc2)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20090093524A1,COC(=O)c1ccc(-c2ccc(OC)cc2Br)cc1>>COC(=O)c1ccc(-c2ccc(O)cc2Br)cc1,,ClCCl,,BrB(Br)Br,,val
US20150025056A1,COC(=O)Cl.COC(=O)[C@H]1C[C@H](OC(C)(C)C)CN[C@@H]1C(=O)N1CCN(c2ccccc2)CC1>>COC(=O)[C@H]1C[C@H](OC(C)(C)C)CN(C(=O)OC)[C@@H]1C(=O)N1CCN(c2ccccc2)CC1,CN(C)c1ccncc1,,,ClCCl,,val
US20100075994A1,C=CC(=O)OCC.NC1=NCC(COc2ccc(C3CCCCC3)cc2)O1>>O=C1CCN2CC(COc3ccc(C4CCCCC4)cc3)OC2=N1,,CCO,ClCCl,CCCCCCC,,val
US04350634,CN(CCCN)CCCc1c[nH]c2ccccc12.O=C(Cl)c1ccccc1>>CN(CCCNC(=O)c1ccccc1)CCCc1c[nH]c2ccccc12,,ClCCl,c1ccncc1,O=C([O-])[O-].[Na+].[Na+],,val
US20030229094A1,C=O.Cc1cc(C(N)=O)ccc1F.c1ccc(N2CCNCC2)nc1>>Cc1cc(C(=O)NCN2CCN(c3ccccn3)CC2)ccc1F,,CCO,,O=C([O-])[O-].[K+].[K+],,val
US20130345242A1,CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](N)C[C@@H]1O[Si](C)(C)C(C)(C)C.Clc1cccc(-c2nc3c(Cl)ncnc3[nH]2)c1>>CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](Nc2nc(-c3cccc(Cl)c3)nc3[nH]cnc23)C[C@@H]1O[Si](C)(C)C(C)(C)C,,CCO,,CCN(C(C)C)C(C)C,,val
US20050234109A1,BrCCCCCBr.O=S(=O)(Cc1cc(F)ccc1F)c1ccc(Cl)cc1>>O=S(=O)(c1ccc(Cl)cc1)C(CCCCCBr)c1cc(F)ccc1F,,C1CCOC1,,[H-].[Na+],,val
US05468742,CCCC[Sn](C#C[Si](C)(C)C)(CCCC)CCCC.CCOC(=O)c1cn(CC)c2c(Br)c(F)c(F)cc2c1=O>>CCOC(=O)c1cn(CC)c2c(C#C[Si](C)(C)C)c(F)c(F)cc2c1=O,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,Cc1ccccc1,,,,val
US20120121615A1,NCCOCCOCCOCCNC(=O)CCCCC(=O)O.O=C(Br)CBr>>O=C(O)CCCCC(=O)NCCOCCOCCOCCNC(=O)CBr,,O,O=CO,CCN(C(C)C)C(C)C,CN(C)C=O,val
US07049312B1,O=C1COc2ccccc2N1.O=Cc1ccc[nH]1>>O=C1Nc2ccccc2OC1=Cc1ccc[nH]1,,CN(C)C=O,,C[O-].[Na+],,val
US20100016311A1,Cn1cc([N+](=O)[O-])cc1C(=O)Cl.Cn1cc([N+](=O)[O-])cc1C(=O)NCCN1CCOCC1>>Cn1cc(NC(=O)c2cc([N+](=O)[O-])cn2C)cc1C(=O)NCCN1CCOCC1,[Pd],CO,ClCCl,,,val
US20100041713A1,CC(C)(C)OC(=O)CBr.O=C1CCCc2c(O)cc(Br)cc21>>CC(C)(C)OC(=O)COc1cc(Br)cc2c1CCCC2=O,,CC#N,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20060074075A1,CC(C)(C)c1cc(Cl)c(O)cc1[N+](=O)[O-]>>CC(C)(C)c1cc(Cl)c(O)cc1N,[Ni],CO,,,,val
US20090318385A1,CC(C)(C)[Si](C)(C)OCc1ccc(C=O)n2nc(C(F)(F)F)cc12>>CC(C)(C)[Si](C)(C)OCc1ccc(CO)n2nc(C(F)(F)F)cc12,,CO,,[BH4-].[Na+],[Cl-].[NH4+],val
US20070254868A1,Brc1cc[nH]c1.ClCCN1CCCC1>>Brc1ccn(CCN2CCCC2)c1,,CN(C)C=O,,[H-].[Na+],,val
US20160009706A1,CO.N#CC12CCN(CC1)CC2.O=C(O)C12CCN(CC1)CC2>>O=C(O)C12CCN(CC1)CC2.OCC12CCN(CC1)CC2,,C1CCOC1,,Cl,,val
US20040162303A1,CC(C)(C)OC(=O)N1CCC(N)CC1.CCS(=O)c1ncc(C(=O)c2c(OC)ccc(F)c2F)c(N)n1>>COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(C(=O)OC(C)(C)C)CC2)nc1N,,CN1CCCC1=O,O,,,val
US07829063B2,CCOC(=O)[C@@H](CSCc1cccc(OCc2cn(C(CO)CF)nn2)c1)NC(=O)Cn1cc(COc2ccc3nc(S(=O)(=O)NC(c4ccccc4)(c4ccc(OC)cc4)c4ccc(OC)cc4)sc3c2)nn1>>NS(=O)(=O)c1nc2ccc(OCc3cn(CC(=O)N[C@H](CSCc4cccc(OCc5cn(C(CO)CF)nn5)c4)C(=O)O)nn3)cc2s1,,CO,O,Cl,[Li+].[OH-],val
US20120225854A1,C1NCC12COC2.CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2COS(C)(=O)=O)cc1)C(F)(F)F>>CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CN2CC3(COC3)C2)cc1)C(F)(F)F,,ClCCl,,CC#N,O=C([O-])[O-].[K+].[K+],val
US20090018103A1,CN(C[C@H](CC1CCCC1)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1>>CN(C[C@@H](N)CC1CCCC1)C(=O)OCc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],,val
US20080318935A1,CC(C)(C)OC(=O)N1CCn2c(-c3ccccc3)nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)c2C1.Cl>>CC12CCC(C1)C(C)(C)C2NC(=O)c1nc(-c2ccccc2)n2c1CNCC2.Cl,,ClCCl,,,,val
US20100093779A1,C#CCC(C)(C)CO.CC(C)(C)[Si](C)(C)Cl>>C#CCC(C)(C)CO[Si](C)(C)C(C)(C)C,,CN(C)C=O,,c1c[nH]cn1,,val
US20110190278A1,CC(C)N(C(=O)c1cc([N+](=O)[O-])c(Cl)cc1C(F)(F)F)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1.CCN>>CCNc1cc(C(F)(F)F)c(C(=O)N(C(C)C)[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)cc1[N+](=O)[O-],,CCO,,,,val
US20050101644A1,NCC1(O)CCN(Cc2cc(Br)ccc2OCc2ccc(Cl)cc2)CC1.O=C=Nc1c(F)cccc1F>>O=C(NCC1(O)CCN(Cc2cc(Br)ccc2OCc2ccc(Cl)cc2)CC1)Nc1c(F)cccc1F,,ClCCl,,CCN(CC)CC,,val
US20160028027A1,CCOC(=O)c1ccc2c(c1)c1ccccc1n2-c1ccccc1.NN>>NNC(=O)c1ccc2c(c1)c1ccccc1n2-c1ccccc1,,O,,CCO,,val
US20070149561A1,CCn1cc(-c2ccnc3[nH]ccc23)c(-c2ccc(N)cc2)n1.O=C(Cl)N1CCOCC1>>CCn1cc(-c2ccnc3[nH]ccc23)c(-c2ccc(NC(=O)N3CCOCC3)cc2)n1,,ClCCl,,CCN(CC)CC,O,val
US20150259346A1,CC(C(N)=O)N1CCC(C(=O)O)c2ccccc21>>CC(CN)N1CCC(CO)c2ccccc21,,C1CCOC1,,B,CSC,val
US20050059702A1,Cc1cccnc1C1CC=CCC(c2ncccc2C)N1C(=O)C(F)(F)F>>Cc1cccnc1C1CC=CCC(c2ncccc2C)N1,,CO,,Cl,,val
US07179823B1,CCOC(=O)c1c[nH]nc1-c1ccccc1.Cc1oc(-c2ccccc2)nc1COc1ccc(CCl)cn1>>CCOC(=O)c1cn(Cc2ccc(OCc3nc(-c4ccccc4)oc3C)nc2)nc1-c1ccccc1,,O,,CN(C)C=O,[H-].[Na+],val
US20110301143A1,C1CCOC1.CC(C)(C)OC(=O)N1CCN(c2ncc(-c3nn[nH]n3)s2)CC1.CCOC(=O)CBr>>CCCCOC(=O)N1CCN(c2ncc(-c3nnn(CC(=O)OCC)n3)s2)CC1,,C1CCOC1,,CCN(CC)CC,O,val
US20160083370A1,COc1cc(OC)nc(N2CCNCC2)n1.Cc1ccc(S(=O)(=O)OCCCc2c[nH]c3ccc(C#N)cc23)cc1>>COc1cc(OC)nc(N2CCN(CCCc3c[nH]c4ccc(C#N)cc34)CC2)n1,,CC#N,,[I-].[K+],,val
US20130225524A1,COc1ncc(-c2ccc3c(Cl)c(C(N)=O)cnc3c2)c(OC)n1.O=[N+]([O-])c1cc(C2=CCCC2)cc([N+](=O)[O-])c1>>COc1ncc(-c2ccc3c(Nc4cc(N)cc(C5CCCC5)c4)c(C(N)=O)cnc3c2)c(OC)n1,[Pd],CC(=O)O,,[H][H],,val
US20050277676A1,N.O=C(O)c1cc(F)ccc1[N+](=O)[O-]>>NC(=O)c1cc(F)ccc1[N+](=O)[O-],,C1CCOC1,,,,val
US20110021520A1,CC(Cl)C(=O)NC(CO)(c1cc(Br)ccc1F)C(F)F>>CC1OCC(c2cc(Br)ccc2F)(C(F)F)NC1=O,,CC#N,,[K+].[OH-],,val
US05350760,C1=COCCC1.O=Cc1cccc(CO)c1>>O=Cc1cccc(COC2CCCCO2)c1,Cc1ccc(S(=O)(=O)O)cc1,ClCCl,,,,val
US20060122394A1,CCOC(=O)c1cnc(N2CCN(C(=O)OC(C)(C)C)CC2)c(Cl)c1>>CCOC(=O)c1cnc(N2CCNCC2)c(Cl)c1,,C1COCCO1,,Cl,,val
US20140315845A1,CN(C)CCN.COC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)C=C(C)[C@H](OC(N)=O)[C@@H](OC)C=CC=C(C)C(=O)NC(=C(c3ccccc3)C1=O)C2=O>>CO[C@H]1C[C@H](C)CC2=C(NCCN(C)C)C(=O)C(c3ccccc3)=C(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)C(C)=C[C@H](C)[C@H]1O)C2=O,,C1CCOC1,,,,val
US05162318,COc1cccc(N)c1.O=[N+]([O-])O>>COc1ccc([N+](=O)[O-])c(N)c1,,CC(=O)O,CC(=O)OC(C)=O,,,val
US20150291549A1,COc1cc(OC)c(C=O)cc1Br>>O=Cc1cc(Br)c(O)cc1O,,ClCCl,,BrB(Br)Br,,val
US20090275537A1,COC(=O)C(F)(F)C[C@@H](COC(=O)OC(C)(C)C)N(C)C(=O)OC(C)(C)C>>CN(C(=O)OC(C)(C)C)[C@H](COC(=O)OC(C)(C)C)CC(F)(F)CO,,C1CCOC1,,[BH4-].[Li+],,val
US20090012093A1,CCOP(=O)(CC(=O)OC(C)(C)C)OCC.O=Cc1ccc(OCc2ccccc2)cc1>>CC(C)(C)OC(=O)/C=C/c1ccc(OCc2ccccc2)cc1,,C1CCOC1,,[H-].[Na+],,val
US20140335166A1,CC1=C2N=C(C=C3N=C(C(C)=C4[N-][C@@](C)([C@@H]5N=C1[C@](C)(CCC(=O)NC[C@@H](C)OP(=O)([O-])O[C@@H]1[C@@H](CO)O[C@H](n6cnc7cc(C)c(C)cc76)[C@@H]1O)[C@H]5CC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]2CCC(N)=O.O=C(O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1.[C-]#N.[Co+3]>>CC1=C2N=C(C=C3N=C(C(C)=C4[N-][C@@](C)([C@@H]5N=C1[C@](C)(CCC(=O)NC[C@@H](C)OP(=O)([O-])O[C@@H]1[C@@H](CO)O[C@H](n6cnc7cc(C)c(C)cc76)[C@@H]1O)[C@H]5CC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]2CCC(N)=O.O=C(O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1.[C-]#N.[Co+3],,O,,CCO,,val
US20100112476A1,COC(=O)c1cccnc1N.O=C=Nc1ccccc1>>O=c1[nH]c2ncccc2c(=O)n1-c1ccccc1,,c1ccncc1,,,,val
US05360800,COC1=CC(=O)N(Cc2ncn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c2C)CC1>>Cc1[nH]cnc1CN1CCC(=O)CC1=O,,C1CCOC1,,Cl,,val
US20120010189A1,CN1CCN(Cc2ccc(OC3CN(C(=O)OC(C)(C)C)C3)cc2F)CC1>>CN1CCN(Cc2ccc(OC3CNC3)cc2F)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20130059835A1,COc1c(C(C)O)cc(Cl)c(C)c1C1CN(C(=O)OC(C)(C)C)C1.Clc1nc(Cl)nc(Cl)n1>>COc1c(C(C)Cl)cc(Cl)c(C)c1C1CN(C(=O)OC(C)(C)C)C1,,ClCCl,ClCCl,CN(C)C=O,O,val
US20160075691A1,Cn1cc(S(=O)(=O)Cl)nn1.Fc1ccc(C2CNN=C2c2cccc(C(F)(F)F)c2)cc1>>Cn1cc(S(=O)(=O)N2CC(c3ccc(F)cc3)C(c3cccc(C(F)(F)F)c3)=N2)nn1,CN(C)c1ccncc1,C1CCOC1,,,,val
US20160237090A1,C[C@H]1Cn2ncc(N3CC(Cn4cccn4)CC3=O)c2CN1C(=O)OC(C)(C)C.O=C(Nc1cc(F)c(F)c(F)c1)Oc1ccccc1>>C[C@H]1Cn2ncc(N3CC(Cn4cccn4)CC3=O)c2CN1C(=O)Nc1cc(F)c(F)c(F)c1,,ClCCl,O=C(O)C(F)(F)F,CCN(C(C)C)C(C)C,,val
US20090137561A1,CCCCOc1ccc(OC)cc1-c1ccc(COc2cccc(CCC(=O)OC)c2)cc1C>>CCCCOc1ccc(OC)cc1-c1ccc(COc2cccc(CCC(=O)O)c2)cc1C,,C1CCOC1,CO,[Li+].[OH-],,val
US20020111352A1,N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(O)c1SC(F)(F)F.O=C(OO)c1cccc(Cl)c1>>N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(O)c1S(=O)C(F)(F)F,,CCOC(C)=O,ClCCl,O=C([O-])O.[Na+],,val
US05773428,CC(C)C[C@H](CC(=O)O)C(=O)N[C@H]1Cc2cn(c3ccccc23)CCCCCCNC1=O>>CC(C)C[C@H](CC(=O)O)C(=O)N[C@H]1CC2CN(CCCCCCNC1=O)C1CCCCC21,,CC(=O)O,,,,val
US20070021423A1,CN(C)c1ccc2nccc(Cl)c2c1.NCCO>>CN(C)c1ccc2nccc(NCCO)c2c1,,O,,[Na+].[OH-],,val
US20090286836A1,Cc1cc(F)ccc1-c1cc([C@H]2CC[C@](C)(C(N)=O)N2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>Cc1cc(F)ccc1-c1cc([C@H]2CC[C@](C)(C(N)=O)N2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(O)CC(O)(CC(=O)O)C(=O)O,,Cc1ccccc1,,,,val
US20030004181A1,CCCCCCOC(=O)Cl.CCCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C)c1ccccc1>>CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCCC)c4ccccc4)ccc3n2C)cc1,,CCO,ClCCl,Cl,,val
US20130274243A1,CC(C)(C)Cc1ccc(N)c([N+](=O)[O-])c1>>CC(C)(C)Cc1ccc(N)c(N)c1,[Pd],CO,,,,val
US20120178748A1,CNc1ccc2c(c1[N+](=O)[O-])CCCC2>>CNc1ccc2c(c1N)CCCC2,[Pd],CO,,[H][H],,val
US04722934,CCOc1nnc(CBr)s1.Oc1ccc(Oc2ccccc2)cc1>>CCOC1=NN=C(Oc2ccc(Oc3ccccc3)cc2)[SH]1C,,CC(C)=O,,CCOC(C)=O,O=C([O-])[O-].[K+].[K+],val
US20110105532A1,CON(C)C(=O)C(C)(F)F.FC(F)(F)c1cccc(I)c1>>CC(F)(F)C(=O)c1cccc(C(F)(F)F)c1,,C1CCOC1,,CC(C)[Mg]Cl,,val
US20110257151A1,CCOC(=O)c1ccc2c(c1)CC(C)(C)C(c1cccc(Br)c1)N2.O=C(O)c1ccc(B(O)O)cc1>>CCOC(=O)c1ccc2c(c1)CC(C)(C)C(c1cccc(-c3ccc(C(=O)O)cc3)c1)N2,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1COCCO1,CCOC(C)=O,O,O=C([O-])[O-].[Na+].[Na+],val
US20020013460A1,C1CN(C2CC2)CCN1.COc1ccc(-c2cc3ccccc3c(Cl)n2)cc1.Cl>>COc1ccc(-c2cc3ccccc3c(N3CCN(C4CC4)CC3)n2)cc1.Cl.Cl,,CS(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20160235734A1,CC(C)(C)OC(=O)N(CC1CCNCC1)C[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c2[nH]c(=O)ccc12.O=C(O)C1CN(C(=O)OCc2ccccc2)C1>>CC(C)(C)OC(=O)N(CC1CCN(C(=O)C2CN(C(=O)OCc3ccccc3)C2)CC1)C[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c2[nH]c(=O)ccc12,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20010025043A1,C1CCOC1.O=C(Cl)C(=O)Cl.O=C(O[C@H]1C[C@@H](CN2C(=O)c3ccccc3C2=O)O[C@@H](n2ccc3ccccc32)C1)c1ccccc1.O=C1CCC(=O)N1O.c1ccncc1>>O=C(O[C@H]1C[C@@H](CN2C(=O)c3ccccc3C2=O)O[C@@H](n2cc(-c3nc4ccccc4[nH]c3=O)c3ccccc32)C1)c1ccccc1,,C1CCOC1,ClCCl,,,val
US06130239,C#C[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)O[Si](C)(C)C(C)(C)C.CCOCC>>C#C[C@H]([C@@H](C)O[Si](C)(C)C(C)(C)C)N(C)C(=O)OC(C)(C)C,,C1CCOC1,,[H-].[Na+],,val
US20010007877A1,Cc1cc(C)n(C(=N)N)n1.Cl.NCCc1cn(S(=O)(=O)c2ccc3ccccc3c2)c2ccc(-c3cccc4ccccc34)cc12>>Cl.N=C(N)NCCc1cn(S(=O)(=O)c2ccc3ccccc3c2)c2ccc(-c3cccc4ccccc34)cc12,,CCO,,CCN(CC)CC,,val
US20090022670A1,Cc1c(C[C@@H]2CCCCN2C(=O)OC(C)(C)C)nc2ccccn12>>Cc1c(C[C@@H]2CCCCN2)nc2ccccn12,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150126498A1,COc1nc(NC(C)=O)ccc1C>>COc1nc(N)ccc1C,,CO,O,[Na+].[OH-],,val
US06114532,CCOC(=O)CN(C(=O)c1ccc2c(c1)nc(Cc1ccc(C(=N)N)cc1)n2C)c1ccccc1.Cl>>Cl.Cn1c(Cc2ccc(C(=N)N)cc2)nc2cc(C(=O)N(CC(=O)O)c3ccccc3)ccc21,,CCO,O,[Na+].[OH-],,val
US04579847,CI.COC(=O)c1cccc(C(=O)Nc2ccc3c(=O)n4c(nc3c2)C(=Cc2ccccc2)CC4)c1>>COC(=O)c1cccc(C(=O)N(C)c2ccc3c(=O)n4c(nc3c2)C(=Cc2ccccc2)CC4)c1,,CN(C)C=O,,CC(=O)O,[H-].[Na+],val
US20050080124A1,COc1ccc(NC(=O)Nc2cccc(C(C)=O)c2)cc1-c1c(Br)cnn1C.NO>>COc1ccc(NC(=O)Nc2cccc(C(C)=NO)c2)cc1-c1c(Br)cnn1C,,CCO,,Cl,Cl,val
US04339587,NCc1ccccn1.O=C(Cl)c1cc(OCc2ccccc2)ccc1OCC(F)(F)F>>O=C(NCc1ccccn1)c1cc(OCc2ccccc2)ccc1OCC(F)(F)F,,CCOCC,c1ccccc1,O,O=C([O-])[O-].[Na+].[Na+],val
US05021402,C=C(C)C=CC(O)CC(C)=CCCOS(=O)(=O)c1ccc(C)cc1>>C=C(C)C=CC1CC(C)=CCCO1,,c1ccncc1,,Cc1ccc(S(=O)(=O)Cl)cc1,,val
US20140121200A1,O=C(O)CCNc1nc(Cl)cc2nccnc12.[NH4+]>>NC(=O)CCNc1nc(Cl)cc2nccnc12,,C1CCOC1,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020068735A1,C[Sn](C)(C)C.Cc1c(Br)c(C#N)n(C)c1-c1ccc2c(c1)C(C)(C)OC(=O)N2>>Cc1c(C)c(-c2ccc3c(c2)C(C)(C)OC(=O)N3)n(C)c1C#N,,CN(C)P(=O)(N(C)C)N(C)C,,O,,val
US20040229900A1,CCN=C=O.N#Cc1ccc(OC[C@@H](O)CN2CC3CNCC(C3)C2)cc1>>CCNC(=O)N1CC2CC(CN(C[C@H](O)COc3ccc(C#N)cc3)C2)C1,,ClCCl,,,,val
US20040132727A1,CC(C)N(CCN)C(C)C.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.S=C(Cl)Cl>>COc1cc2nccc(Oc3cc(C)c(NC(=S)NCCN(C(C)C)C(C)C)cc3C)c2cc1OC,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US20060154917A1,CCc1cccc(CC)c1-c1nc(C)c(C=O)s1>>CCc1cccc(CC)c1-c1nc(C)c(CO)s1,,CO,,[BH4-].[Na+],,val
US20080207695A1,CCI.O=Cc1cc(F)c[nH]c1=O>>CCn1cc(F)cc(C=O)c1=O,,COCCOC,,O=C([O-])[O-].[K+].[K+],,val
US05846982,O=S(=O)(c1ccccc1)n1c(C2=CCN(Cc3ccccc3)CC2)cc2ccccc21>>C1=C(c2cc3ccccc3[nH]2)CCN(Cc2ccccc2)C1,,CCO,,,,val
US20090048269A1,Cc1ccc(O)c(Cl)n1.Clc1cc(I)ccn1>>Cc1ccc(Oc2ccnc(Cl)c2)c(Cl)n1,I[Cu]I,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20150105317A1,CC(=O)O[C@@H]1[C@H](C)O[C@@H](OCCNC(=O)OCc2ccccc2)[C@@H](OC(C)=O)[C@@H]1OC(C)=O>>CC(=O)O[C@@H]1[C@H](C)O[C@@H](OCCN)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,[Pd],O,,,,val
US20110301122A1,CI.COC(=O)c1c[nH]c(Br)c1>>COC(=O)c1cc(Br)n(C)c1,,CN(C)C=O,,CC(C)(C)[O-].[K+],,val
US20080182851A1,Br[Mg]Cc1ccccc1.CC(C)(C)OC(=O)N1CCC(=O)CC1>>CC(C)(C)OC(=O)N1CCC(O)(Cc2ccccc2)CC1,,CCOCC,,,,val
US20120288492A1,CSc1c(Cl)nc(-c2ccc(NC(=O)NCCCl)cc2)nc1N1CCOCC1>>CSc1c(Cl)nc(-c2ccc(N3CCNC3=O)cc2)nc1N1CCOCC1,,O,,C1CCOC1,[Na+].[OH-],val
US08471005B2,CC(C)(O)CN1CCN(c2cccc([N+](=O)[O-])c2)CC1>>CC(C)(O)CN1CCN(c2cccc(N)c2)CC1,[Pd],CO,,[H][H],,val
US20070213336A1,CCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)OC)cc2OCCCCC)c1>>CCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)O)cc2OCCCCC)c1,,C1CCOC1,CO,[Na+].[OH-],,val
US20070161673A1,CC(=O)OC(OC(C)=O)c1cc(Cl)ncc1Cl.Cc1c(F)cc(C(=O)NC2CC2)cc1B(O)O>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1cc(C=O)c(Cl)cn1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CC(C)O,,O=C([O-])O.[Na+],,val
US20130116289A1,CC(C)(C)OC(=O)C(C)(C)N.N#Cc1ccc(CBr)c(F)c1>>CC(C)(C)OC(=O)C(C)(C)NCc1ccc(C#N)cc1F,,CN(C)C=O,,O,O=C([O-])O.[Na+],val
US20110059957A1,CC(=O)N1CCN(c2ccc(CCc3ccc(CCOS(C)(=O)=O)cc3)nc2)CC1.[N-]=[N+]=[N-]>>CC(=O)N1CCN(c2ccc(CCc3ccc(CCN=[N+]=[N-])cc3)nc2)CC1,,CN(C)C=O,,O,,val
US20090163488A1,Cc1cc(C(=O)Nc2cc(Oc3ccc(N)nc3)ccc2F)n(C)n1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(F)c(NC(=O)c4cc(C)nn4C)c3)cn2)cc1,,c1ccncc1,,,,val
US20150191419A1,O=C(O)CCCCBr.OCc1ccccc1>>O=C(CCCCBr)OCc1ccccc1,Cc1ccc(S(=O)(=O)O)cc1,Cc1ccccc1,,,,val
US20160031871A1,CC(C)(C)OC(=O)N1CCC(Cc2ccc3c(c2)OCO3)CC1.Cl>>Cl.c1cc2c(cc1CC1CCNCC1)OCO2,,C1COCCO1,,,,val
US20070105943A1,O=C1NC(=O)c2ccccc21.OCc1cccc(Sc2ccccc2)c1>>O=C1c2ccccc2C(=O)N1Cc1cccc(Sc2ccccc2)c1,,C1CCOC1,O,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06395750B1,CCNc1ccccc1.CCOC(=O)c1c(O)c2c(N(C)C)cccc2n(C)c1=O>>CCN(C(=O)c1c(O)c2c(N(C)C)cccc2n(C)c1=O)c1ccccc1,,Cc1ccccc1,,CCO,,val
US20100120865A1,C[Si](C)(C)I.Cc1cc(NC(=O)CCNC(=O)OC(C)(C)C)no1>>Cc1cc(NC(=O)CCN)no1.I,,CC#N,,CO,,val
US20090253679A1,CC(=O)NCC(=O)O.O=Cc1c[nH]c2ncccc12>>CC1=N/C(=C\c2c[nH]c3ncccc23)C(=O)O1,,CC(=O)OC(C)=O,,CC(=O)[O-].[Na+],,val
US20070265225A1,CCC12CCC(c3ccccc3)(CN1)N(CC(=O)OCc1ccccc1)C2=O>>CCC12CCC(c3ccccc3)(CN1)N(CC(=O)O)C2=O,[Pd],CO,,[H][H],,val
US20090233896A1,N#Cc1cncc(-c2cnc(Nc3cc(N4CCOCC4)ccn3)s2)c1.OO>>NC(=O)c1cncc(-c2cnc(Nc3cc(N4CCOCC4)ccn3)s2)c1,,CCO,,[Na+].[OH-],,val
US20030095958A1,CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)C(C(=O)Nc2ccc3ccccc3c2)C1>>CC(C)(C)OC(=O)N1CCNC(C(=O)Nc2ccc3ccccc3c2)C1,,CO,,,,val
US20100267666A1,CC(C)(CCCC#N)C(=O)O.O=C(Cl)C(=O)Cl>>CC(C)(CCCC#N)C(=O)Cl,,ClCCl,,,,val
US20020055639A1,Cn1nc(-c2ncc(Cl)cc2F)cc1O.FC(F)Cl>>Cn1nc(-c2ncc(Cl)cc2F)cc1OC(F)F,,CCCCCC,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US06140326,C1CO1.CC1(C)COC(=O)C(C)(C)N1>>CC1(C)COC(=O)C(C)(C)N1CCO,,CO,,Cl,,val
US20080287409A1,[N-]=[N+]=NCc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc(-c2noc(=O)[nH]2)c(F)c1>>NCc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc(-c2noc(=O)[nH]2)c(F)c1,,CN(C)C=O,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US20050119489A1,CC(=O)C(Cl)C(C)=O.O=C(OCC1c2ccccc2-c2ccccc21)N1CCC(S)CC1>>CC(=O)C(SC1CCN(C(=O)OCC2c3ccccc3-c3ccccc32)CC1)C(C)=O,,CCOCC,,,,val
US20160024021A1,CC(C)(C)OC(=O)N1CCC[C@@H](n2cc([N+](=O)[O-])cn2)C1>>CC(C)(C)OC(=O)N1CCC[C@@H](n2cc(N)cn2)C1,[Pd],CO,,,,val
US20110207781A1,Clc1cc(Cl)c(OC[C@@H]2CCCN2)c(Cl)c1.O=C(Cl)c1cccnc1Cl>>O=C(c1cccnc1Cl)N1CCC[C@H]1COc1c(Cl)cc(Cl)cc1Cl,,ClCCl,,CCN(CC)CC,,val
US20060142385A1,CC(C)CCBr.O=[N+]([O-])c1ccc(O)cc1>>CC(C)CCOc1ccc([N+](=O)[O-])cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120077781A1,Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCCCCCC(=O)OC(C)(C)C)c2cc1Cl.NC1CC1>>Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCCCCCC(=O)OC(C)(C)C)c2cc1NC1CC1,,CN(C)C=O,,,,val
US04904690,CC(=O)c1cc(Cl)cc(C)c1O.COC(=O)C1CCCCC1>>Cc1cc(Cl)cc(C(=O)CC(=O)C2CCCCC2)c1O,,Cc1ccccc1,O,Cl,[H-].[Na+],val
US20150031685A1,CN[C@H](CN1CC[C@H](O[Si](C)(C)C(C)(C)C)C1)c1cccc(C(=O)N(C)C)c1.O=C(O)Cc1ccc2sc(=O)[nH]c2c1>>CN(C)C(=O)c1cccc([C@@H](CN2CC[C@H](O[Si](C)(C)C(C)(C)C)C2)N(C)C(=O)Cc2ccc3sc(=O)[nH]c3c2)c1,,CCOC(C)=O,CN(C)C=O,CCN=C=NCCCN(C)C,On1nnc2ccccc21,val
US04619917,C=CCCBr.CCCCCCCCCCCCCCCCCCOCCC(=O)COCc1ccccc1>>C=CCCC(O)(CCOCCCCCCCCCCCCCCCCCC)COCc1ccccc1,,CCOCC,,[Mg],,val
US20160185798A1,CCC(C)CN=C=O.Clc1cccc(C#CC2=C3CCNC3ON2)c1>>CCC(CC)NC(=O)N1CCC2C(C#Cc3cccc(Cl)c3)=NOC21,,ClCCl,,CCN(CC)CC,O,val
US20030166639A1,Cc1ccc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)ccc3NC(=O)OC(C)(C)C)c2)cn1>>Cc1ccc(-c2cccc(C3=Nc4ccc(C(F)(F)F)cc4NC(=O)C3)c2)cn1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20140024650A1,CC(C)(C)[Si](OC[C@H]1OCCC[C@H]1O)(c1ccccc1)c1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CC(C)(C)[Si](OC[C@H]1OCCC[C@@H]1N=[N+]=[N-])(c1ccccc1)c1ccccc1,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030060460A1,COC(=O)c1ccc(COc2cc(C(F)(F)F)ccc2NS(=O)(=O)c2ccccc2)cc1.COCCl.O=C(O)CN(c1ccc(C(F)(F)F)cc1OCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccccc1>>COCOC(=O)CN(c1ccc(C(F)(F)F)cc1OCc1ccc(C(=O)OCOC)cc1)S(=O)(=O)c1ccccc1,,CN(C)C=O,O,CCN(CC)CC,,val
US20160024095A1,CSc1ncc(C(C)=O)c(CCNc2cc(-c3ncc(C)cc3C)c(Cl)cn2)n1>>CSc1ncc2c(n1)CCN(c1cc(-c3ncc(C)cc3C)c(Cl)cn1)C2C,,ClCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US20140100373A1,CC(=O)N(C)C.CCN(CC)CC.ClC(c1ccccc1)(c1ccccc1)c1ccccc1.O>>O=Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1,,CO,,,,val
US20150183801A1,CCN(C(C)C)C(C)C.CNCCCO.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(Br)c1>>CCN(C(C)C)C(C)C.CN(CCCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1Br.Cl,,CC(C)O,,,,val
US20090111860A1,CC=O.O=C1CC([C@@H](Cc2ccccc2)NS(=O)(=O)c2ccc(Cl)cc2)=NO1>>C/C=C1\C(=O)ON=C1[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(Cl)cc1,,CCO,,,,val
US20080032992A1,CCOC(=O)c1cc(C#N)c(N2CCNCC2)nc1C.O=Cc1cn(-c2ccccc2)nn1>>CCOC(=O)c1cc(C#N)c(N2CCN(Cc3cn(-c4ccccc4)nn3)CC2)nc1C,,CO,,CC(=O)O,,val
US20080070929A1,C=C1CN(c2ccc3c(c2)OC(F)(F)O3)/C(=N/C(=O)OCC)S1>>CCOC(=O)/N=c1\sc(C)cn1-c1ccc2c(c1)OC(F)(F)O2,,CO,,C[O-].[Na+],,val
US05567841,CC=Cc1cccc(O)c1>>CCCc1cccc(O)c1,[Pd],C1CCOC1,,[H][H],,val
US20140309193A1,BrCc1ccccc1.CCOC(=O)c1c(O)c(O)c(C(=O)OCC)n1-c1ccc(OC)cc1>>CCOC(=O)c1c(O)c(OCc2ccccc2)c(C(=O)OCC)n1-c1ccc(OC)cc1,,CCO,,CCN(C(C)C)C(C)C,,val
US20070148566A1,C=CCCCC.CCC12CCC(C=C1c1ccccc1)C2.Cc1cc(C)cc(C)c1.Cc1ccccc1>>C1=CC2(CCc3ccccc3)CCC1C2.CCCCCCC12C=CC(CC1)C2,,Cc1cc(C)cc(C)c1,,ClCCl,,val
US03940418,CCN(CC)CCCl.O=C(O)c1nn(-c2ccc(Cl)cc2)c2c1CCc1ccccc1-2>>CCN(CC)CCOC(=O)c1nn(-c2ccc(Cl)cc2)c2c1CCc1ccccc1-2,,CC(C)O,,,,val
US20050085508A1,C=CCC1(CO[Si](CC)(CC)CC)CCCCC1.OO>>CC[Si](CC)(CC)OCC1(CCCO)CCCCC1,,C1CCOC1,,O,[Na+].[OH-],val
US20100331318A1,BrCc1ccccc1.O=[N+]([O-])c1cccc(F)c1O>>O=[N+]([O-])c1cccc(F)c1OCc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05739333,COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(S(C)(=O)=O)nc1OCCOc1ncc(Br)cn1.NCCO>>COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(NCCO)nc1OCCOc1ncc(Br)cn1,,CC(=O)N(C)C,,[Cl-].[NH4+],,val
US20120232056A1,COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCCC3)nc2c1>>O=C(O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCCC3)nc2c1,,CO,O,Cl,[Na+].[OH-],val
US20040186160A1,CN(C)CCCc1c(C=O)[nH]c2c1CCCCC2.O=C1Cc2cc(-c3ccccc3)ccc2N1>>CN(C)CCCc1c(/C=C2\C(=O)Nc3ccc(-c4ccccc4)cc32)[nH]c2c1CCCCC2,,CCO,,C1CCNCC1,,val
US05082856,CCCCCCCCCCCCCCBr.CCOC(=O)c1cc[nH]c1>>CCCCCCCCCCCCCCn1ccc(C(=O)OCC)c1,,O,,CN(C)C=O,[H-].[Na+],val
US05698575,O=c1c(I)coc2ccc(Cl)cc12.c1cn[nH]c1>>O=c1cc(-c2cc[nH]n2)oc2ccc(Cl)cc12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20090042900A1,CC(C)(C)OC(=O)N1CCN(CCO)CC1.N#Cc1c(F)cccc1F>>CC(C)(C)OC(=O)N1CCN(CCOc2cccc(F)c2C#N)CC1,,CN(C)C=O,,[H-].[Na+],,val
US20160039815A1,CC(C)CC(O)c1c(-c2cccc(Cl)c2)ncc2c1c(=O)n(CCCO[Si](C)(C)C(C)(C)C)c(=O)n2C.O=CO>>CC(C)CCc1c(-c2cccc(Cl)c2)ncc2c1c(=O)n(CCCOC=O)c(=O)n2C,[Zn],CCOC(C)=O,O,,,val
US20050004189A1,CCOC(=O)CC(Cc1csc(CCCc2ccc3c(n2)NCCC3)n1)c1cnc(-c2ccc(Cl)cc2)s1.Cl>>Cl.O=C(O)CC(Cc1csc(CCCc2ccc3c(n2)NCCC3)n1)c1cnc(-c2ccc(Cl)cc2)s1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20160128989A1,COc1cccc(-c2nn(C3CCCCO3)c3nc(-c4ccc(N)c(C#N)c4)cc(C(F)F)c23)c1>>COc1cccc(-c2n[nH]c3nc(-c4ccc(N)c(C#N)c4)cc(C(F)F)c23)c1,,C1COCCO1,CO,Cl,O=C([O-])O.[Na+],val
US20150141406A1,COc1nccc2c1c(-c1ccc(S(N)(=O)=O)cc1)nn2C(C)(C)C>>COc1nccc2[nH]nc(-c3ccc(S(N)(=O)=O)cc3)c12,,O,O=C(O)C(F)(F)F,,,val
US20040132727A1,CCI.COc1cc2ncnc(Oc3ccc(NC(=O)OCc4ccccc4Cl)c(Cl)c3)c2cc1OC>>CCN(C(=O)OCc1ccccc1Cl)c1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl,,O,,CN(C)C=O,[H-].[Na+],val
US05387603,CC(=O)OC(C)=O.CCOc1ccccc1OCCN(C(=O)OC(C)(C)C)C(C)Cc1cc2c(c(C(N)=O)c1)N(CCO)CC2>>CCOc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCOC(C)=O)CC2,,ClCCl,,CCN(CC)CC,,val
US20150329533A1,Cc1c(CN)nn(-c2ccccc2)c1CC(C)C.O=S(=O)(Cl)c1ccccc1>>Cc1c(CNS(=O)(=O)c2ccccc2)nn(-c2ccccc2)c1CC(C)C,,ClCCl,,CCN(CC)CC,,val
US20040142942A1,CCOC(=O)c1cnc(C)[nH]c1=O.Cc1cc(C(=O)CBr)c(C)o1>>CCOC(=O)c1cnc(C)n(CC(=O)c2cc(C)oc2C)c1=O,,COCCOC,,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val
US20130102776A1,CC(=O)OC(C)=O.COc1cc(C(C)=O)c(O)c(CN2CCN(C(=O)OC(C)(C)C)CC2)c1OC>>COc1cc(C(C)=O)c(OC(C)=O)c(CN2CCN(C(=O)OC(C)(C)C)CC2)c1OC,CN(C)c1ccncc1,c1ccncc1,,,,val
US05919793,COCCOc1ccc(C#CC2(O)CN3CCC2CC3)cc1>>COCCOc1ccc(CCC2(O)CN3CCC2CC3)cc1,[Pd],CCO,,[H][H],,val
US04929741,C#CC(=O)OC.COc1ccc(C=O)c(OC)c1OC>>COC(=O)C#CC(O)c1ccc(OC)c(OC)c1OC,,C1CCOC1,,[Li]CCCC,[Cl-].[NH4+],val
US20030069438A1,COC(=O)C[C@]1(CNC(=O)OC)CC[C@@H](C)C1.Cl>>C[C@@H]1CC[C@@](CN)(CC(=O)O)C1.Cl,,C1COCCO1,O,,,val
US20110065681A1,COCc1cc(C(=O)O)cc(-c2ccc(C)cn2)c1.Cc1ncc([C@@H](C)N)cn1>>COCc1cc(C(=O)N[C@H](C)c2cnc(C)nc2)cc(-c2ccc(C)cn2)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080249089A1,FC(F)(F)C1Cc2ccccc2C(CCl)=N1>>Cc1nc(C(F)(F)F)cc2ccccc12,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20100331315A1,CC(C)(C)OC(=O)NC1CCC(N)CC1.CC(C)N(C)C(C)C.Clc1cncc(Cl)n1>>C[C@H](Nc1cncc(Cl)n1)c1ccccc1,,CN(C)C=O,,O,,val
US20030224006A1,NC(=O)N1c2ccccc2C=Cc2ccccc21.O=C(O)c1cc(C(=O)O)cc([N+](=O)[O-])c1>>NC(=O)N1c2ccccc2C=Cc2ccccc21.O=C(O)c1cc(C(=O)O)cc([N+](=O)[O-])c1,,CO,,CCO,,val
US20120077737A1,CC(=O)c1ccc(C(=O)O)s1.C[Mg]Br>>CC(C)(O)c1ccc(C(=O)O)s1,,C1CCOC1,,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US20120157451A1,CS/C(=C\C#N)N1CCCC1.NN>>Nc1cc(N2CCCC2)n[nH]1,,CCO,,O,,val
US04511392,CO.C[O-].O=C(Nc1nc(Cl)nc(Cl)n1)NS(=O)(=O)c1ccccc1-c1cnoc1>>COc1nc(NC(=O)NS(=O)(=O)c2ccccc2-c2cnoc2)nc(OC)n1,,O,,Cl,,val
US20020173469A1,CC(C)C(=O)Cl.Nc1ccc(-c2ccccc2)cc1>>CC(C)C(=O)Nc1ccc(-c2ccccc2)cc1,,ClCCl,,CCN(CC)CC,,val
US20090197863A1,COC(=O)c1cccc(N)c1O.Cc1ccc(C(=O)O)cc1>>COC(=O)c1cccc2nc(-c3ccc(C)cc3)oc12,,O,,,,val
US20050049286A1,COC(=O)c1sccc1N.Cc1cc(C)c(N2CCCC2)c(C)c1N>>Cc1cc(C)c(N2CCCC2)c(C)c1NC(=O)c1sccc1N,,ClCCCl,,C[Al](C)C,Cl,val
US06512152B1,C1=CC2CC1C1C3CCC(C3)C21.Cc1ccccc1>>C1=CC2C3C=CC(C3)C2C1.C1=CC2CCC1C2,,Cc1ccccc1,,,,val
US04886834,COc1ccc(C(=C(C#N)CCC(=O)O)c2ccc(OC)cc2)cc1.OCCO>>COc1ccc(C(=C(CCC(=O)O)C(N)=O)c2ccc(OC)cc2)cc1,,OCCO,,Cl,[Na+].[OH-],val
US20090143448A1,CCc1csc(N)n1.ClI>>CCc1nc(N)sc1I,,ClCCl,,CC(=O)O,,val
US20150119394A1,Cc1ccc(S(=O)(=O)OC[C@@H]2CN(C(=O)OC(C)(C)C)CCO2)cc1.Oc1ccc(-c2ccccc2Cl)cc1>>CC(C)(C)OC(=O)N1CCO[C@H](COc2ccc(-c3ccccc3Cl)cc2)C1,,CCOC(C)=O,CN(C)C=O,[H-].[Na+],,val
US20060069142A1,OCCc1ccccc1F>>O=CCc1ccccc1F,,ClCCl,,O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1,,val
US20150259316A1,CCN(CC)c1ccc(C=O)c(O)c1.CCOC(=O)CC(=O)c1ccccc1>>CCN(CC)c1ccc2cc(C(=O)c3ccccc3)c(=O)oc2c1,,CCO,,C1CCNCC1,,val
US20100004249A1,CC(C)(C)OC(=O)N1CCNC(CO)C1.O=C=Nc1cccc(C(F)(F)F)c1>>CC(C)(C)OC(=O)N1CCN(C(=O)Nc2cccc(C(F)(F)F)c2)C(CO)C1,,C1CCOC1,,,,val
US20090012093A1,COC(=O)CCc1ccc(OCc2ccc(N)cc2)cc1.O=C(Cl)c1ccccc1>>COC(=O)CCc1ccc(OCc2ccc(NC(=O)c3ccccc3)cc2)cc1,,C1CCOC1,,CCN(CC)CC,O,val
US20090197871A1,Cc1cc(Br)cc(C(=O)O)c1.N>>Cc1cc(Br)cc(C(N)=O)c1,,CCOC(C)=O,,O=C(n1ccnc1)n1ccnc1,,val
US05041541,Br.CC(=O)OCC1(COC(C)=O)OC(OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O>>CC(=O)OCC1(COC(C)=O)O[C@@H](Br)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O,,CC(=O)O,,,,val
US20130196974A1,CC1(C)OCC(CN)O1.Cc1ccc2nc(Cl)nc(Cl)c2c1>>Cc1ccc2nc(Cl)nc(NCC3COC(C)(C)O3)c2c1,,CCOC(C)=O,CO,CCN(CC)CC,,val
US04537698,CCCC1CCC(O)CC1.CCCCCC1CCN(C2CCC(C(=O)O)CC2)CC1>>CCCCCC1CCN([C@@H]2CC[C@@H](C(=O)O[C@@H]3CC[C@@H](CCC)CC3)CC2)CC1,,Cc1ccccc1,O,O=S(Cl)Cl,c1ccncc1,val
US20070123535A1,CC1(C)OC(=O)C(C(c2c[nH]c3ncccc23)C2CCCCC2)C(=O)O1.CN>>CNC(=O)CC(c1c[nH]c2ncccc12)C1CCCCC1,,O,,c1ccncc1,,val
US20060142359A1,CC(C)(C)C(=O)OC(=O)C(C)(C)C.Nc1onc2c1CCC2>>CC(C)(C)C(=O)Nc1onc2c1CCC2,,Cc1ccccc1,,,,val
US20080139559A1,CCN(CC)CCOc1cccc(N)c1.CCN(CC)CCOc1cccc([N+](=O)[O-])c1.CO>>CCN(CC)CCOc1cc(N)ccc1C(=O)OC,[Pd],,,,,val
US04337341,COc1cccc([C@@]23CCC[C@H]2CN(C)CC3)c1>>COc1cccc([C@@]23CCC[C@@H]2CN(C)CC3)c1,O=[Pt],,,,,val
US04447441,N.NC(=NCC(F)(F)F)Nc1cccc(SCCCC(=O)O)n1>>NC(=O)CCCSc1cccc(NC(N)=NCC(F)(F)F)n1,,CCO,CN(C)C=O,CC(C)COC(=O)Cl,CCN(CC)CC,val
US20040176365A1,CO.N#CCOC(=O)c1cccnc1Nc1ccc2nsnc2c1>>COC(=O)c1cccnc1Nc1ccc2nsnc2c1,,CO,,CCN(CC)CC,,val
US20110166169A1,CC(C)(C)OC(=O)c1ccc(-n2c3ccccc3c3c(-c4ccc(C#N)nc4)cccc32)cc1NC1CCOCC1>>N#Cc1ccc(-c2cccc3c2c2ccccc2n3-c2ccc(C(=O)O)c(NC3CCOCC3)c2)cn1,,C1COCCO1,,Cl,,val
US20110041471A1,CCCCCCCCCCCCCCCCCCO.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>CCCCCCCCCCCCCCCCCCOC(=O)c1ccc([N+](=O)[O-])cc1,,ClCCl,,c1ccncc1,,val
US20060223801A1,C1COCCN1.COC(=O)C1(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)C=CN=C(Cl)N1>>COC(=O)c1cc(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)nc(N2CCOCC2)n1,,CN(C)C=O,O,CCOC(C)=O,,val
US20110136735A1,CCOC(=O)C1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1>>CC1(C(=O)O)CCC(N2C(=O)c3ccccc3C2=O)CC1,,CC(=O)O,,Cl,,val
US20030125332A1,N#CCC(=O)NN.O=CC(=O)c1ccccc1>>N#Cc1c(-c2ccccc2)cn[nH]c1=O,,CCO,,,,val
US20120101136A1,CCc1cc(OCCBr)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1.CN>>CCc1cc(OCCNC)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1,,C1CCOC1,,,,val
US20030229094A1,COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1cccc(NC(=O)CN2CCN(c3ccccn3)C[C@@H]2C)c1>>Cc1cccc(NC(=S)CN2CCN(c3ccccn3)C[C@@H]2C)c1,,Cc1ccccc1,,,,val
US20090298823A1,CNc1ccc([N+](=O)[O-])cc1.O=C(Cl)COCc1ccccc1>>CN(C(=O)COCc1ccccc1)c1ccc([N+](=O)[O-])cc1,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US20140051712A1,CCOC(=O)C=NO.COc1ccc(CCl)cc1>>CCOC(=O)C=NOCc1ccc(OC)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100016279A1,CN1CCNCC1.O=C(CCCCl)Nc1cccc(C2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)c1>>CN1CCN(CCCC(=O)Nc2cccc(C3CCN(c4ccc5nnc(C(F)(F)F)n5n4)CC3)c2)CC1,,C1CCOC1,CC(=O)N(C)C,[I-].[Na+],,val
US20090239846A1,CN(CCN)C(=O)OC(C)(C)C.Cc1ccc(C(=O)NC(C)C)cc1-c1nc(S(C)=O)nc2c1CNC(=O)N2c1c(F)cccc1F>>Cc1ccc(C(=O)NC(C)C)cc1-c1nc(NCCN(C)C(=O)OC(C)(C)C)nc2c1CNC(=O)N2c1c(F)cccc1F,,C1CCOC1,,CCN(C(C)C)C(C)C,,val
US06518268B1,BrCc1ccc(Br)cc1.c1ccc(Nc2ccccc2)cc1>>Brc1ccc(CN(c2ccccc2)c2ccccc2)cc1,,CN(C)C=O,,O,[H-].[Na+],val
US20090281097A1,CCOC(=O)c1sc2nc(C)ccc2c1Br>>Cc1ccc2c(Br)c(C(=O)O)sc2n1,,CCO,O,Cl,[Na+].[OH-],val
US20150111931A1,CC1(Br)CC1.COC(=O)c1ccc(OC(F)F)c(O)c1>>COC(=O)c1ccc(OC(F)F)c(OCC2CC2)c1,,CN(C)C=O,O,[I-].[K+],O=C([O-])O.[Na+],val
US20100048636A1,CC(C)(C)OC(=O)N1CCC[C@@H](C(=O)c2cccc(Cl)c2)C1.CC(C)(C)[Si](C)(C)OCCCCCl>>CC(C)(C)OC(=O)N1CCC[C@@H]([C@@](O)(CCCCO[Si](C)(C)C(C)(C)C)c2cccc(Cl)c2)C1,,C1CCOC1,,,,val
US20110180784A1,NC1CCCCC1.O=C1OC(=O)c2ccc3c4c(ccc1c24)CC3>>O=C(O)c1ccc2c3c(ccc(C(O)=NC4CCCCC4)c13)CC2,,CC(=O)N(C)C,,O,,val
US20020147343A1,O=C1Cc2c(ccc(F)c2/C(I)=C/C(=O)c2ccc[nH]2)N1.OCCS>>O=C1Nc2ccc(F)c3c(SCCO)cc(-c4ccc[nH]4)c1c23,,CCOC(C)=O,O,[H-].[Na+],,val
US20060116410A1,CS(=O)(=O)Cl.N#Cc1ccc(CNC(=O)c2cc(N)c(F)c(Cl)c2)c(OCC(N)=O)c1>>CS(=O)(=O)Nc1cc(C(=O)NCc2ccc(C#N)cc2OCC(N)=O)cc(Cl)c1F,,ClCCl,,c1ccncc1,,val
US20050027007A1,CC(C)(C)NC(=O)[C@@H]1CN(NC(=O)OC(C)(C)C)CCN1NC(=O)Cc1ccccc1>>CC(C)(C)NC(=O)[C@@H]1CN(NC(=O)OC(C)(C)C)CCN1,[Pd],CO,,[H][H],,val
US06387893B1,O=C1c2ccccc2-c2cccnc21>>c1ccc2c(c1)Cc1ncccc1-2,,ClC(Cl)Cl,,NN,O,val
US20100311966A1,CCOC(=O)c1sc(N2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)[C@H](OCC)C2)nc1CNC>>CCO[C@@H]1CN(c2nc3c(s2)C(=O)N(C)C3)CC[C@@H]1NC(=O)c1nc(Cl)c(CC)[nH]1,,Cc1ccccc1,,C[Al](C)C,Cl,val
US20060211734A1,CC1(C)CC(O)CCN1Cc1ccccc1.Clc1cccc(Cl)n1>>CC1(C)CC(Oc2cccc(Cl)n2)CCN1Cc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US05190971,C1=COCCC1.CCOC(=S)Sc1ccc(C)cc1CO>>CCOC(=S)Sc1ccc(C)cc1COC1CCCCO1,,ClCCl,,Cc1ccc(S(=O)(=O)O)cc1,,val
US05824691,COC(=O)c1cc(N)cc(-n2cccc2)c1.O=C(Br)CBr>>COC(=O)c1cc(NC(=O)CBr)cc(-n2cccc2)c1,,ClCCl,,CCOC(C)=O,c1ccncc1,val
US05578596,CCOC(=O)CCCOc1cnc2c(n1)CCCC2>>OCCCCOc1cnc2c(n1)CCCC2,,C1CCOC1,,Cl,[Al+3].[H-].[H-].[H-].[H-].[Li+],val
US05922724,COC1CCC(OC)O1.Nc1cccc([N+](=O)[O-])c1>>O=[N+]([O-])c1cccc(-n2cccc2)c1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20120277207A1,CC(Cl)COC(=O)N1CC(=O)Nc2ncc(/C=C/C(=O)N3CC(OCc4cccs4)C3)cc2C1>>O=C1CNCc2cc(/C=C/C(=O)N3CC(OCc4cccs4)C3)cnc2N1,,CO,,,,val
US20090270460A1,CC(=O)c1ccc(O)cc1C.CC(C)c1cnn(-c2c(Cl)cccc2Cl)c1CO>>CC(=O)c1ccc(OCc2c(C(C)C)cnn2-c2c(Cl)cccc2Cl)cc1C,,Cc1ccccc1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20090291942A1,BrCc1ccc(Br)cc1.CCCc1nc2c(C)cc(C)nc2[nH]1>>CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(Br)cc1,,CN(C)C=O,,[H-].[Na+],,val
US20100216746A1,Cc1nc(Cl)c(C(=O)O)[nH]1.N#Cc1cc(Br)cc(Oc2c(Cl)ccc(CN)c2F)c1>>Cc1nc(Cl)c(C(=O)NCc2ccc(Cl)c(Oc3cc(Br)cc(C#N)c3)c2F)[nH]1,,CCOC(C)=O,CN(C)C=O,ClCCCl,On1nnc2ccccc21,val
US20100144722A1,COC(=O)C1(c2ccc(Nc3nc(NC4CC5CCC4C5)cc(-c4ccccc4)n3)cc2)CCC1>>O=C(O)C1(c2ccc(Nc3nc(NC4CC5CCC4C5)cc(-c4ccccc4)n3)cc2)CCC1,,CO,O,[Na+].[OH-],,val
US20080269240A1,CN(CCCCl)C(=O)OC(C)(C)C.COCCOc1nc(N)c2nc(OC)n(CC3CCN(C(=O)OC(C)(C)C)CC3)c2n1>>COCCOc1nc(N)c2nc(OC)n(CC3CCN(CCCN(C)C(=O)OC(C)(C)C)CC3)c2n1,,O=C(O)C(F)(F)F,,O=C([O-])[O-].[K+].[K+],,val
US20100256181A1,Fc1c(C(F)(F)F)ccnc1Cl.Oc1cc(Cl)cc(Cl)c1>>FC(F)(F)c1ccnc(Cl)c1Oc1cc(Cl)cc(Cl)c1,,O,,CN1CCCC1=O,O=C([O-])[O-].[K+].[K+],val
US20090198063A1,COc1ncc2ccc(=O)n(CC3OCCO3)c2n1>>COc1ncc2ccc(=O)n(CC=O)c2n1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,O=C([O-])O.[Na+],val
US20120259123A1,CC(C)(C)Cc1ccc(CC(NS(=O)(=O)c2ccccn2)c2cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)cc1.Cl>>CC(C)(C)Cc1ccc(CC(NS(=O)(=O)c2ccccn2)c2cccc(NCC(=O)O)n2)cc1.Cl,,ClCCl,,C1COCCO1,,val
US20090209755A1,CO[C@H]1CC[C@H]2CSC(NC(=O)c3ccccc3)=N[C@@]2(c2ccccc2F)C1>>CO[C@H]1CC[C@H]2CSC(N)=N[C@@]2(c2ccccc2F)C1,,CO,,C1CCC2=NCCCN2CC1,,val
US20130143860A1,Cc1ccnc(N2CCOCC2)n1.O=C1CCC(=O)N1Br>>Cc1nc(N2CCOCC2)ncc1Br,,CCCCCC,,ClCCl,,val
US20090137561A1,CCN(CC)S(F)(F)F.COc1ccc(F)c(-c2ccc(CO[Si](C)(C)C(C)(C)C)cc2C(O)C(C)(C)C)c1>>COc1ccc(F)c(-c2ccc(CO[Si](C)(C)C(C)(C)C)cc2C(F)C(C)(C)C)c1,,Cc1ccccc1,,O,,val
US20050191229A1,Brc1ccc2c(c1)Cc1ccccc1-2.CN(C)C=O.COCCBr>>COC1(OC)c2ccccc2-c2cccc(CCBr)c21,,O,,CC(C)(C)[O-].[K+],,val
US06077812,COc1c(I)c(Cl)cc(F)c1-n1c(=O)cc(C(F)(F)F)n(C)c1=O>>Cn1c(C(F)(F)F)cc(=O)n(-c2c(F)cc(Cl)c(I)c2O)c1=O,,ClCCl,,BrB(Br)Br,O,val
US20160002228A1,CC(C)n1nc(N2C(=O)c3ccccc3C2=O)cc1C1CCN(C(=O)OC(C)(C)C)CC1>>CC(C)n1nc(N)cc1C1CCN(C(=O)OC(C)(C)C)CC1,,CO,,NN,O,val
US20080132459A1,CC(C)(C)OC(=O)Nc1cscc1NC(=O)OC(C)(C)C.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)Nc1csc(Br)c1NC(=O)OC(C)(C)C,,ClC(Cl)(Cl)Cl,,,,val
US07547703B2,CC(=O)N1C(=O)C(=C(O)c2ccc(C#N)cc2)c2ccc(Cl)cc21.ClP(Cl)(Cl)(Cl)Cl>>CC(=O)N1C(=O)C(=C(Cl)c2ccc(C#N)cc2)c2ccc(Cl)cc21,,C1COCCO1,,,,val
US20120202783A1,Cc1cccc(N2C[C@@H]3CCN(C(=O)OC(C)(C)C)C[C@@H]32)n1>>Cc1cccc(N2C[C@@H]3CCNC[C@@H]32)n1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150315197A1,CC(C)(C)OC(=O)N1CC=C(c2cccc(F)c2Cl)CC1>>CC(C)(C)OC(=O)N1CCC(c2cccc(F)c2Cl)CC1,O=[Pt]=O,CCOC(C)=O,,,,val
US06005103,C1CCNCC1.CCO.O=c1oc(-c2ccccc2)cc(O)c1SSc1c(O)cc(-c2ccccc2)oc1=O.SC1CCCCC1>>O=c1oc(-c2ccccc2)cc(O)c1C(CC1CCCC1)SC1CCCCC1,,CC(=O)O,,,,val
US20080132509A1,COCOc1ccc(Cl)nc1.C[Sn](C)(C)Cl>>COCOc1ccc([Sn](C)(C)C)nc1,,COCCOC,,[Na],,val
US20020193399A1,COC(=O)C1(C)c2ccccc2CN1C(=O)OC(C)(C)C.Cl>>COC(=O)C1(C)NCc2ccccc21.Cl,,C1COCCO1,,,,val
US20120253035A1,CC1(C)OCC(=O)N[C@](C)(c2cc(C#Cc3cccc(Cl)c3)ccc2F)C1(F)F.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC1(C)OCC(=S)N[C@](C)(c2cc(C#Cc3cccc(Cl)c3)ccc2F)C1(F)F,,C1COCCO1,,,,val
US20030225283A1,CS(=O)(=O)c1ccc([C@@H](CC2CCCC2=O)C(=O)Nc2cnccn2)cc1Cl>>CS(=O)(=O)c1ccc([C@@H](CC2CCCC2O)C(=O)Nc2cnccn2)cc1Cl,,CCO,O,[BH4-].[Na+],,val
US20150148342A1,Cc1ccc(S(=O)(=O)n2ccc3c(-c4ccc5c([nH]c(=O)n5C)c4Oc4ccc(F)cc4F)cn(C)c(=O)c32)cc1>>Cn1cc(-c2ccc3c([nH]c(=O)n3C)c2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O,,CCO,,O,[Na+].[OH-],val
US20110021501A1,CC(C)(C)OC(=O)N1CCC(c2c[nH]c3ccccc23)CC1.CI>>Cn1cc(C2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21,,CN(C)C=O,,[H-].[Na+],,val
US05296495,COc1ccc2oc(C(=O)NC3CCCCNC3=O)cc2c1.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>COc1ccc2oc(-c3nc4c(s3)NCCCC4)cc2c1,,c1ccncc1,,,,val
US06670373B1,CC#CC(=O)OCC.ON=C(Cl)c1c(F)cccc1I>>CCOC(=O)c1c(-c2c(F)cccc2I)noc1C,,CCOCC,,CCN(CC)CC,,val
US20060178416A1,O=[N+]([O-])c1ccc(F)cc1.SC1CCCC1>>O=[N+]([O-])c1ccc(SC2CCCC2)cc1,,CC#N,O,O=C([O-])[O-].[K+].[K+],,val
US03991202,CC(C)(C)NCc1ccccc1.O=C(Cl)CCl>>CC(C)(C)N(Cc1ccccc1)C(=O)CCl,,ClCCCl,,[Na+].[OH-],,val
US20020165275A1,NNC(=O)c1cc(OCc2ccc3ccccc3c2)cc([N+](=O)[O-])c1.O=C(Br)c1ccccc1>>O=C(NNC(=O)c1cc(OCc2ccc3ccccc3c2)cc([N+](=O)[O-])c1)c1ccccc1,,CC(=O)N(C)C,,CCN(CC)CC,,val
US20070225280A1,CCOC(=O)c1cnn(C2CCCCC2)c1Cl>>O=C(O)c1cnn(C2CCCCC2)c1Cl,,CO,,O,[Li+].[OH-],val
US20140275071A1,C[Si](C)(C)CCOCCl.O=c1[nH]c(=O)c2c(nc(Cl)n2Cc2ccc(Cl)cc2)[nH]1>>C[Si](C)(C)CCOCn1c(=O)[nH]c(=O)c2c1nc(Cl)n2Cc1ccc(Cl)cc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20120101127A1,Cc1ccc(N)cc1.O=Cc1cccc([N+](=O)[O-])c1>>Cc1ccc(/N=C/c2cccc([N+](=O)[O-])c2)cc1,,CCO,,,,val
US20110294793A1,O=C(c1cccc(CNCc2ccc(F)cc2)c1)N(Cc1ccc(F)cc1)Cc1cc(Cl)cc(Cl)c1.O=S(=O)(Cl)c1cc(Cl)cc(Cl)c1O>>O=C(c1cccc(CN(Cc2ccc(F)cc2)S(=O)(=O)c2cc(Cl)cc(Cl)c2O)c1)N(Cc1ccc(F)cc1)Cc1cc(Cl)cc(Cl)c1,,C1CCOC1,,CCN(CC)CC,,val
US20050277630A1,CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCSC(=CN(C)C)C3=O)C(=O)O1.NN>>CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCSc2cn[nH]c2-3)C(=O)O1,,CCO,,O,,val
US20070099908A1,O=C(COCc1ccccc1)NC[C@H]1CCc2ccc(S(=O)(=O)c3ccccc3)cc2O1>>O=C(CO)NC[C@H]1CCc2ccc(S(=O)(=O)c3ccccc3)cc2O1,,CO,,[H][H],,val
US20040102483A1,NNC(=O)CC(=O)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1.S=C=Nc1ccccc1>>O=C(Cc1nnc(Nc2ccccc2)o1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1,,CN(C)C=O,,,,val
US20060189602A1,CC(C)CCn1nc(-c2cccs2)c(O)c(C(=O)Nc2cc(Cl)sc2S(N)(=O)=O)c1=O>>CC(C)CCn1nc(-c2cccs2)c(O)c(C2=NS(=O)(=O)c3sc(Cl)cc3N2)c1=O,,c1ccncc1,,C1CCC2=NCCCN2CC1,,val
US20050113442A1,CCNC(=O)c1ccc(CCl)cc1.NC(=O)[C@@H]1CCCC[C@@H]1NS(=O)(=O)c1ccc(Cl)cc1>>CCNC(=O)c1ccc(CN([C@@H]2CCCC[C@@H]2C(N)=O)S(=O)(=O)c2ccc(Cl)cc2)cc1,,CCOC(C)=O,CN(C)C=O,[I-].[K+],O=C([O-])[O-].[Cs+].[Cs+],val
US06376664B1,Cn1c(-c2ccccc2[N+](=O)[O-])nc2c(C3OCCO3)cccc21>>Cn1c(-c2ccccc2N)nc2c(C3OCCO3)cccc21,[Pd],CO,,,,val
US20070208062A1,CS(=O)(=O)Cl.NCCOC[C@@H]1CC(c2ccc(Br)cn2)=NO1>>CS(=O)(=O)NCCOC[C@@H]1CC(c2ccc(Br)cn2)=NO1,CN(C)c1ccncc1,ClCCl,,c1ccncc1,,val
US20030120021A1,Nc1nc(N)nc(N)n1.O=P(Cl)(c1ccccc1)c1ccccc1>>Nc1nc(N)nc(N)n1.O=P(Cl)(c1ccccc1)c1ccccc1,,CC(=O)N(C)C,,,,val
US20030229094A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C1CCCN(Cc2ccccc2)C1>>CC(C)(C)OC(=O)N1CCCC(=O)C1,[Pd],CO,,CCN(CC)CC,[H][H],val
US20020022612A1,C=CC(=O)OCC.Cc1cc(Cl)ccc1O>>CCOC(=O)CCOc1ccc(Cl)cc1C,,CCO,,[Na],,val
US20020156292A1,CCOC(=O)CNC(=O)c1c[nH]c(C=O)c1C.CNS(=O)(=O)c1ccc2c(c1C)CC(=O)N2>>CCOC(=O)CNC(=O)c1c[nH]c(C=C2C(=O)Nc3ccc(S(=O)(=O)NC)c(C)c32)c1C,,CCO,,C1CCNCC1,,val
US04954518,COC(=O)/C=C/Oc1ccc(Oc2ccc(F)cc2F)c(NS(C)(=O)=O)c1>>CS(=O)(=O)Nc1cc(O/C=C/C(=O)O)ccc1Oc1ccc(F)cc1F,,CCOC(C)=O,,Cl,[Na+].[OH-],val
US20110130361A1,CC(C)(C)OC(=O)N1C[Si](C)(C)C[C@H]1C(=O)O.CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(CN)cc1>>CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(CNC(=O)[C@@H]2C[Si](C)(C)CN2C(=O)OC(C)(C)C)cc1,,CCOC(C)=O,CN(C)C=O,ClCCCl,On1nnc2ccccc21,val
US20130040983A1,C[Si](C)(C)CCOCn1c(-c2ccccc2)nc(-c2ccncc2)c1Br.Nc1cccc(B(O)O)c1>>C[Si](C)(C)CCOCn1c(-c2ccccc2)nc(-c2ccncc2)c1-c1cccc(N)c1,,COCCOC,,CCOC(C)=O,Cl,val
US20140249130A1,Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(C3(O)CCNCC3)nc2)c1.O=C(O)c1ccc2cccnc2c1.On1nnc2ccccc21>>Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(C3(O)CCN(C(=O)c4ccc5cc[nH]c5n4)CC3)nc2)c1,,CN(C)C=O,ClCCCl,CCN(C(C)C)C(C)C,,val
US05646140,COc1ccc(NC(C)C)cc1.O=C(Br)CBr>>COc1ccc(N(C(=O)CBr)C(C)C)cc1,,ClCCl,,CCN(CC)CC,,val
US20070027185A1,COC(=O)c1cnccc1NC(=O)OC(C)(C)C>>COC(=O)c1cnccc1N,,O=C(O)C(F)(F)F,,,,val
US20120289526A1,Cc1cccc(Oc2ccc(NC(=O)[C@@H](C)N(C(=O)[O-])C(C)(C)C)cn2)c1C>>Cc1cccc(Oc2ccc(NC(=O)[C@@H](C)N)cn2)c1C,,ClCCl,,O=C(O)C(F)(F)F,,val
US04247550,NCC=CCc1cc(N)c(Oc2ccccc2)c(S(N)(=O)=O)c1.O=Cc1ccccc1>>NCC=CCc1cc(NCc2ccccc2)c(Oc2ccccc2)c(S(N)(=O)=O)c1,,CO,O,CC(=O)O,[BH4-].[Na+],val
US20160016966A1,C[C@@H]1CN(S(C)(=O)=O)CCN1Cc1cc2c(=O)n(C)cc(-c3ccncc3N)c2o1.O=CC1CC1>>C[C@@H]1CN(S(C)(=O)=O)CCN1Cc1cc2c(=O)n(C)cc(-c3ccncc3NCC3CC3)c2o1,,CC(=O)O,CO,,,val
US20070082912A1,CCOC(=O)c1cccc(-n2c(C)ccc2-c2cc(Br)ccc2O)c1.Clc1ccc(CBr)cc1>>CCOC(=O)c1cccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(Cl)cc2)c1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US06667342B1,CC(=O)OC(C)(C)C(=O)Cl.Nc1ccc(S(=O)(=O)F)cc1Cl>>CC(=O)OC(C)(C)C(=O)Nc1ccc(S(=O)(=O)F)cc1Cl,,ClCCl,,c1ccncc1,,val
US20150329506A1,CC(C)OB(OC(C)C)OC(C)C.Cc1noc(C)c1[C@@H]1C[C@@](C)(c2cc(Br)c(F)cc2F)N=C(NC(=O)OC(C)(C)C)S1>>Cc1noc(C)c1[C@@H]1C[C@@](C)(c2cc(B(O)O)c(F)cc2F)N=C(NC(=O)OC(C)(C)C)S1,,C1CCOC1,O,Cl,[Li]CCCC,val
US20160096842A1,CCC(CC)[C@H](NC(C)=O)[C@H]1[C@H](N)C[C@H](C(=O)OC)[C@H]1O.CSC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C>>CCC(CC)[C@H](NC(C)=O)[C@H]1[C@H](NC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)C[C@H](C(=O)OC)[C@H]1O,Cl[Hg]Cl,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,,val
US04301159,CCN(CC)CCNC(=O)c1cc([N+](=O)[O-])cc(C)c1OC>>CCN(CC)CCNC(=O)c1cc(N)cc(C)c1OC,O=[Pt],CO,,[H][H],,val
US20120165331A1,Cc1ccc(S(=O)(=O)n2cc(CN3CCCC4(CCN(C(=O)OC(C)(C)C)C4)C3=O)c3ccccc32)cc1.Cl>>Cc1ccc(S(=O)(=O)n2cc(CN3CCCC4(CCNC4)C3=O)c3ccccc32)cc1.Cl,,ClCCl,,C1COCCO1,,val
US20100105655A1,COc1cc(F)ccc1[N+](=O)[O-].OCCN1CC2CNCC(C1)O2>>COc1cc(N2CC3CN(CCO)CC(C2)O3)ccc1[N+](=O)[O-],,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US05070087,Fc1ccc(Br)cc1F.O=C(c1ccc(F)cc1)C1CCN(S(=O)(=O)c2ccccc2)CC1>>O=S(=O)(c1ccccc1)N1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)c(F)c2)CC1,,C1CCOC1,,[Mg],[Cl-].[NH4+],val
US20100137313A1,COc1cc(C)cc(Nc2ncc(-c3cnc(OC)c(C(=O)O)c3)c(-n3nc(C(F)(F)F)cc3C)n2)c1.CS(N)(=O)=O>>COc1cc(C)cc(Nc2ncc(-c3cnc(OC)c(C(=O)NS(C)(=O)=O)c3)c(-n3nc(C(F)(F)F)cc3C)n2)c1,CN(C)c1ccncc1,ClCCl,ClCCl,CCN(CC)CC,C[n+]1ccccc1Cl.[I-],val
US04267341,O=C1[CH2+]=CSN1c1ccccc1.O=P(Cl)(Cl)Cl>>Clc1ccs[n+]1-c1ccccc1.[Cl-],,CCOCC,,,,val
US20110098290A1,COCOc1cc(OCOC)c(C(C)C)cc1C(=O)OC>>COCOc1cc(OCOC)c(C(C)C)cc1C(=O)O,,CO,O,[K+].[OH-],,val
US20020156081A1,C1COCCN1.COc1cc(-c2nn(CCOS(C)(=O)=O)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C>>COc1cc(-c2nn(CCN3CCOCC3)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C,,CN(C)C=O,,CCN(CC)CC,[I-].[Na+],val
US04450164,BrCc1ccccc1.Nc1cccnc1N>>Nc1ncccc1NCc1ccccc1,,CCN(CC)CC,,CCO,,val
US04857100,C=C=COc1ccccc1S(N)(=O)=O.COc1nc(C)nc(N(C(=O)[O-])c2ccccc2)n1>>C=C=COc1ccccc1S(=O)(=O)NC(=O)Nc1nc(C)nc(OC)n1,,C1COCCO1,O,C1CCC2=NCCCN2CC1,Cl,val
US20120022080A1,O=C(Nc1ccc(C2=CCCCC2)cc1C(=O)O)c1ccc(C2CCCCC2)cc1>>O=C(Nc1ccc(C2CCCCC2)cc1C(=O)O)c1ccc(C2CCCCC2)cc1,[Pd],CN(C)C=O,,CCO,,val
US20020032166A1,CCCCCCCCCCCCO.N=C(N)NCCC[C@H](N)C(=O)O>>CCCCCCCCCCCCOC(=O)[C@@H](N)CCCNC(=N)N,,CCOCC,,O=S(=O)(O)O,,val
US20150284370A1,Cc1cc(=O)c(C#N)c(N)o1>>Cc1cc(O)c(C#N)c(=O)[nH]1,,Cl,,,,val
US20100234316A1,CCOC(=O)[C@H](C)N.O=P(Cl)(Cl)Oc1cccc2ccccc12>>CCOC(=O)[C@H](C)NP(=O)(Cl)Oc1cccc2ccccc12,,ClCCl,,CCN(CC)CC,Cl,val
US20150141400A1,CCS(=O)(=O)c1ccc(Cl)cc1N(C(=O)OC(C)(C)C)n1cnc2c(Br)cc(C)cc2c1=O>>CCS(=O)(=O)c1ccc(Cl)cc1Nn1c(=O)[nH]c2c(Br)cc(C)cc2c1=O,,C1CCOC1,O,Cl,[Na+].[OH-],val
US20060148858A1,CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.COC(=O)Cc1ccc(OC)cc1O>>COc1ccc(CC(=O)O)c(OCCCc2cn(-c3ccc(C(F)(F)F)cn3)nc2C(C)C)c1,,C1CCOC1,,CCCCP(CCCC)CCCC,O=C(N=NC(=O)N1CCCCC1)N1CCCCC1,val
US20130338179A1,CCCc1cc(N2C[C@H](O)C[C@H]2C(=O)O)nc(Nc2ccc(F)cc2)n1.CO>>CCCc1cc(N2C[C@H](O)C[C@H]2C(=O)OC)nc(Nc2ccc(F)cc2)n1,,CO,,O=S(=O)(O)O,O=C([O-])O.[Na+],val
US20050267149A1,CCNCCc1ccccn1.O=C(O)CCc1ccc(O)cc1>>CCN(CCc1ccccn1)C(=O)CCc1ccc(O)cc1,,CCOC(C)=O,CN(C)C=O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20130102776A1,CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2OCC3=O)CC1.Cc1ccc(S(=O)(=O)n2cc(C=O)c3ccccc32)cc1>>Cc1ccc(S(=O)(=O)n2cc(/C=C3\Oc4c(ccc(O)c4CN4CCN(C(=O)OC(C)(C)C)CC4)C3=O)c3ccccc32)cc1,,CO,,C1CCNCC1,,val
US20070185062A1,Cc1cn(C(=O)[C@H](OC(=O)c2ccccc2)[C@H](CO)OCP(=O)(OC(C)C)OC(C)C)c(=O)[nH]c1=O>>Cc1cn(C(=O)[C@H](O)[C@H](CO)OCP(=O)(OC(C)C)OC(C)C)c(=O)[nH]c1=O,,CO,,N,,val
US20130035446A1,O=C(O)/C=C/c1ccc(C(F)(F)Oc2ccc(OCCCC(F)(F)F)cc2)cc1.O=[N+]([O-])c1cc(CO)cc([N+](=O)[O-])c1>>O=C(/C=C/c1ccc(C(F)(F)Oc2ccc(OCCCC(F)(F)F)cc2)cc1)OCc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1,CN(C)c1ccncc1,ClCCl,,CCN=C=NCCCN(C)C,Cl,val
US20110009454A1,O=C(O)c1cccc(Oc2ccccc2)c1F.O=S(Cl)Cl>>O=C(Cl)c1cccc(Oc2ccccc2)c1F,CN(C)C=O,Cc1ccccc1,,,,val
US20050227959A1,CC(=O)OC1CCc2c(S(=O)(=O)N(C)CCc3ccc(F)cc3)csc2C1=O.NO>>CC(=O)OC1CCc2c(S(=O)(=O)N(C)CCc3ccc(F)cc3)csc2/C1=N\O,,CCOC(C)=O,c1ccncc1,Cl,,val
US05559266,CC(Cl)OC(=O)Cl.OCc1cccs1>>CC(Cl)OC(=O)OCc1cccs1,,ClC(Cl)Cl,,c1ccncc1,,val
US20100075990A1,N#Cc1cccnc1.OB(O)c1cccc(F)c1.c1ccc(Cn2ccnc2-c2ccccc2)cc1.c1ccc(Cn2ccnc2-c2cccnc2)cc1>>Fc1cccc(-c2ncc(-c3cnc(-c4cccnc4)[nH]3)cn2)c1,,CO,ClCCl,,,val
US20110152273A1,NCc1ccccc1.O=[N+]([O-])C=CC(F)(F)F>>O=[N+]([O-])CC(NCc1ccccc1)C(F)(F)F,,Cc1ccccc1,,,,val
US04285874,Nc1cccc2c1C(=O)c1ccccc1C2=O.O=C(Cl)Cl>>O=C=Nc1cccc2c1C(=O)c1ccccc1C2=O,,Clc1ccccc1Cl,,,,val
US04749790,N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1.N[C@@H](CC(=O)O)C(=O)O>>N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1.N[C@@H](CC(=O)[O-])C(=O)[O-],,ClCCl,,,,val
US20050187282A1,COc1cccc(NC(=O)OC(C)(C)C)c1CCO>>Nc1cccc2c1CCO2,,CC(=O)O,,Br,[Na+].[OH-],val
US20060178418A1,COc1c(-c2ccc([N+](=O)[O-])cc2)cc(C(=O)[O-])c2c3cc(Cl)ccc3n(C)c12.Nc1c(Cl)cncc1Cl>>COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2c3cc(Cl)ccc3n(C)c12,,CN(C)C=O,,[H-].[Na+],,val
US20150018422A1,CCOC(=O)CC(c1cccc(COc2cnc(-c3cc(OC4CCCCO4)ccc3F)c(CC(C)(C)C)c2)c1)C1CC1>>CC(C)(C)Cc1cc(OCc2cccc(C(CC(=O)O)C3CC3)c2)cnc1-c1cc(OC2CCCCO2)ccc1F,,CCO,,Cl,[Na+].[OH-],val
US20050096336A1,Cc1nc(-c2cccc(C(F)(F)F)c2)ccc1CO>>Cc1nc(-c2cccc(C(F)(F)F)c2)ccc1C=O,O=[Mn]=O,ClCCl,,,,val
US20110172442A1,COC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)C=Cc1ccc(F)cc1>>COc1ccc(C[C@H](NC(=O)C=Cc2ccc(F)cc2)C(=O)O)cc1,,CO,,[Na+].[OH-],,val
US20150218092A1,BrCCOC1CCCCO1.CCc1cc([N+](=O)[O-])ccc1O>>CCc1cc([N+](=O)[O-])ccc1OCCOC1CCCCO1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US04861785,Fc1ccc(OC2CCC(OCc3ccccc3)CC2)cc1>>OC1CCC(Oc2ccc(F)cc2)CC1,[Pd],CO,,[H][H],,val
US20130079329A1,C1CCNC1.O=C(O)c1ccc([N+](=O)[O-])cn1>>O=C(c1ccc([N+](=O)[O-])cn1)N1CCCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US04005217,N#C[S-].Nc1ccccc1N.O=C(Cl)OCCCl>>Nc1ccccc1NC(=S)NC(=O)OCCCl,,CC#N,,O,,val
US20100152493A1,COC(=O)CBr.COc1cc(C=O)cc(OC)c1O>>COC(=O)COc1c(OC)cc(C=O)cc1OC,,ClCCl,,CCN(C(C)C)C(C)C,O,val
US20020049204A1,Cc1cc(Br)ccc1F.O=C1CCC(=O)N1Br>>Fc1ccc(Br)cc1CBr,,ClC(Cl)(Cl)Cl,,,,val
US20110105761A1,CCCBr.COc1ccccc1-n1ccnc1>>CCCn1cc[n+](-c2ccccc2OC)c1.[Br-],,C1CCOC1,,,,val
US20040077669A1,CC#CC(C)O.Clc1cc(Cl)ncn1>>CC#CC(C)Oc1cc(Cl)ncn1,,C1CCOC1,,[H-].[Na+],[Cl-].[NH4+],val
US20070254881A1,CCOC(=O)C(=O)CC(=O)c1ccc(C)nc1.COc1ccc(NN)cn1>>CCOC(=O)c1cc(-c2ccc(C)nc2)n(-c2ccc(OC)nc2)n1,,CCO,ClC(Cl)Cl,CC(=O)O,O=C([O-])O.[Na+],val
US20130116430A1,Cc1ccc(-c2cncc(NC(=O)OC(C)(C)C)c2)o1>>Cc1ccc(-c2cncc(N)c2)o1,,ClC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20080188484A1,CC(C)N1CCC(Oc2cc3cc(C(=O)N4CCN(S(=O)(=O)C5CC5)CC4)n(CCO[Si](C)(C)C(C)(C)C)c3cc2Br)CC1>>CC(C)N1CCC(Oc2cc3cc(C(=O)N4CCN(S(=O)(=O)C5CC5)CC4)n(CCO)c3cc2Br)CC1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20150051225A1,BrBr.CC(=O)C1CC(C)(C)OC(C)(C)C1>>CC1(C)CC(C(=O)CBr)CC(C)(C)O1,,CCO,,,,val
US20070010670A1,COc1ccc2c(c1)N(C(=O)c1cc(Cl)c(O)c(Cl)c1)CCO2>>O=C(c1cc(Cl)c(O)c(Cl)c1)N1CCOc2ccc(O)cc21,,ClCCl,,BrB(Br)Br,O,val
US05652235,CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CNc1ccccc12.CCS(=O)(=O)Cl>>CCS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)CC2)c2ccccc21,,ClCCl,,CN1CCOCC1,,val
US20040204498A1,CCOC(=O)c1nc(S(C)(=O)=O)n(C)c(=O)c1OCc1ccccc1.N>>CCOC(=O)c1nc(N)n(C)c(=O)c1OCc1ccccc1,,CC#N,,,,val
US20060074072A1,COP(=O)(C[C@@H](N)C(=O)Nc1ccc(N2CCOCC2=O)cc1)OC.O=C=Nc1ccc(Cl)cc1>>COP(=O)(C[C@@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)Nc1ccc(N2CCOCC2=O)cc1)OC,,ClCCl,,,,val
US20050176727A1,CCI.ON=C(CCN1CCCC(c2nccs2)C1)c1ccc(F)cc1>>CCON=C(CCN1CCCC(c2nccs2)C1)c1ccc(F)cc1,,CC(C)(C)O,,CC(C)(C)[O-].[K+],,val
US20020156311A1,CNC.Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2cccc(OCCCBr)c2)cc1>>Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2cccc(OCCCN(C)C)c2)cc1,,C1CCOC1,,,,val
US20040186132A1,BrC(Br)(Br)Br.CC(C)(C)OC(=O)N1c2ccc(-c3ccccc3)cc2C(CO)=CC1(C)C>>CC(C)(C)OC(=O)N1c2ccc(-c3ccccc3)cc2C(CBr)=CC1(C)C,,ClCCl,,c1ccc(P(c2ccccc2)c2ccccc2)cc1,,val
US06498174B1,CC(=O)c1cccc(C)c1.CCC(=O)CC(=O)c1ccccc1>>CC(=O)CC(=O)c1cccc(C)c1,,CCOC(C)=O,,,,val
US20120225862A1,CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.Cc1cc(CN)ccc1C(=O)Nc1cccnc1>>Cc1cc(CNS(=O)(=O)c2ccc(C(C)(C)C)cc2)ccc1C(=O)Nc1cccnc1,,c1ccncc1,,,,val
US20060235050A1,NCC#CCNC(=O)CCCCC(c1ccc(F)cc1)c1ccc(F)cc1.O=C(O)c1ccc(Cl)cc1>>O=C(CCCCC(c1ccc(F)cc1)c1ccc(F)cc1)NCC#CCNC(=O)c1ccc(Cl)cc1,CN(C)c1ccncc1,ClCCl,,ClCCCl,,val
US20140073620A1,CC(C(N)=O)c1ccccc1CCc1nc(Cl)ncc1Cl.CC(C)(C)OC(=O)n1cc(N)cn1>>CC(C(N)=O)c1ccccc1CCc1nc(Nc2cn[nH]c2)ncc1Cl,,CO,O,,,val
US05306728,CCOC(=O)COCc1ccsc1>>O=C(O)COCc1ccsc1,,CCO,,CC(=O)O,[Na+].[OH-],val
US06100257,CC(C)Oc1cc(I)c(F)cc1Cl.O=C[O-]>>CC(C)Oc1cc(C=O)c(F)cc1Cl,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,CN(C)C=O,,Cl,,val
US20090042897A1,NC(N)=S.O=C(CBr)c1ncccc1F>>Nc1nc(-c2ncccc2F)cs1,,CCO,ClCCl,,,val
US06310095B1,CC(C)(C)OC(=O)CBr.CCCCC(=S)OC>>CCCC(CC(=O)OC(C)(C)C)C(=S)OC,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Na+],,val
US20070219235A1,Nc1ccc(C(=O)O)cc1[N+](=O)[O-].Nc1ccc2cn[nH]c2c1>>Nc1ccc(C(=O)Nc2ccc3cn[nH]c3c2)cc1[N+](=O)[O-],,CN(C)C=O,,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20120108582A1,C[C@H](c1ccccc1)N1CC(CC2CO2)(C(=O)OC(C)(C)C)CC1=O>>C[C@H](c1ccccc1)N1C[C@]2(C(=O)OC(C)(C)C)CC(O)C[C@@H]2C1=O,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20040132727A1,COc1cc2ncnc(Oc3ccc(NC(=O)COc4ccccc4O)cc3)c2cc1OC>>COc1cc2ncnc(Oc3ccc(NCCOc4ccccc4O)cc3)c2cc1OC,,C1CCOC1,,Cl,[Na+].[OH-],val
US20080214532A1,CCC(C)(C)c1cccc(NC=O)c1C>>CCC(C)(C)c1cccc(N)c1C,,O,,CO,[K+].[OH-],val
US04876367,CCOCC.CN(C)C=O.COC(=O)c1cc(C(C)(C)CC(C)(C)C)ccc1O.ClCCOCCOCCOC1CCCCO1>>CCCCCCCCC1=CC(C(=O)OC)C(O)(OCCOCCOCCOC2CCCCO2)C=C1,,CCOCC,,O=C([O-])[O-].[K+].[K+],,val
US20080269266A1,CC(=O)c1ncccn1.NC1CCCCC1>>CC(=NC1CCCCC1)c1ncccn1,,Cc1ccccc1,,,,val
US20110065681A1,Cc1ccc(-c2cc(C(=O)O)cc(C(O)c3ccccn3)c2)cc1.Cc1ccc(CN)cn1>>Cc1ccc(-c2cc(C(=O)NCc3ccc(C)nc3)cc(C(O)c3ccccn3)c2)cc1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20100137281A1,CCOC(=O)c1c(N)sc(OC)c1C.C[C@@H](N)c1ccccc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1sc2[nH]c(=O)n([C@H](C)c3ccccc3)c(=O)c2c1C,,ClCCl,,CCN(CC)CC,,val
US20010039347A1,COc1ccc(I)cc1.O=C1CCCN1>>COc1ccc(N2CCCC2=O)cc1,[Cu],,,O=C([O-])[O-].[K+].[K+],,val
US20040132721A1,CCOc1ccc(C2=NN(c3ccc(C(=O)N4CCN(c5ccccc5)CC4)cc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OCC.O=C(c1ccco1)N1CCNCC1>>CCOc1ccc(C2=NN(c3ccc(C(=O)N4CCN(C(=O)c5ccco5)CC4)cc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OCC,,CCOCC,,Cl,,val
US05891889,O=S(Cl)Cl.OCc1cccc(OCc2ccccc2)n1>>ClCc1cccc(OCc2ccccc2)n1,,c1ccccc1,,,,val
US20130225673A1,CC(=O)CCl.O=Cc1cccc(F)c1O>>CC(=O)c1cc2cccc(F)c2o1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20090137610A1,COc1ccc(CCN2C(=O)N(CC(C)C)C(=O)C23CCCN(Cc2ccccc2)C3)cc1>>COc1ccc(CCN2C(=O)N(CC(C)C)C(=O)C23CCCNC3)cc1,[Pd],CC(=O)O,,[H][H],,val
US20140336190A1,Cc1noc(C)c1-c1cc(N)c(N)c(I)c1.N#CBr>>Cc1noc(C)c1-c1cc(I)c2nc(N)[nH]c2c1,,CC#N,CCO,O,O=C([O-])O.[Na+],val
US20160130299A1,CC(C)[C@H](C(=O)OCc1ccccc1)N(C)C(=O)OC(C)(C)C>>CN[C@@H](C(=O)OCc1ccccc1)C(C)C,,C1COCCO1,,Cl,,val
US20050032873A1,NC(=O)c1ccc(F)c2c1C[C@@H](NCCCc1c[nH]c3c(F)cc(F)cc13)CO2.O=CC1CC1>>NC(=O)c1ccc(F)c2c1C[C@@H](N(CCCc1c[nH]c3c(F)cc(F)cc13)CC1CC1)CO2,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US04271164,CN=C=O.Cc1ncc2cc(-c3c(Cl)cccc3Cl)c(N)nc2n1>>CNC(=O)Nc1nc2nc(C)ncc2cc1-c1c(Cl)cccc1Cl,,CCOCC,,,,val
US20050049276A1,CCOC(=O)c1cn2ccnc2cc1Nc1ccc(I)cc1F>>O=C(O)c1cn2ccnc2cc1Nc1ccc(I)cc1F,,C1CCOC1,,Cl,[Na+].[OH-],val
US20090182007A1,N#Cc1ccccc1CBr.c1c[nH]cn1>>N#Cc1ccccc1Cn1ccnc1,,CN(C)C=O,,O,[H-].[Na+],val
US20100331365A1,CC(=O)CCCCl.COC(=O)Cc1ccc2c(c1)C(=C1CCNCC1)c1sccc1CO2>>COC(=O)Cc1ccc2c(c1)C(=C1CCN(CCCC(C)=O)CC1)c1sccc1CO2,,CN(C)C=O,,[I-].[K+],,val
US05441949,C=CCBr.Nc1cc(C(=O)O)nc2ccccc12>>C=CCOC(=O)c1cc(N)c2ccccc2n1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20060173043A1,COC(=O)CCC1=CCCN(Cc2ccc(OC)cc2OC)C1=O.NO[K]>>COc1ccc(CN2CCC=C(CCC(=O)NO)C2=O)c(OC)c1,,CCOC(C)=O,CO,CC(=O)O,,val
US20150274688A1,CCCCN(CCCC)CCCOc1ccc(C(=O)Cl)cc1.CNOC>>CCCCN(CCCC)CCCOc1ccc(C(=O)N(C)OC)cc1,,ClCCl,,Cl,c1ccncc1,val
US20050272669A1,BrCCOCc1ccccc1.Cc1cc(OCc2ccccc2)ccc1Cc1c(O[C@@H]2O[C@H](COC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@H](OC(=O)C(C)(C)C)[C@H]2OC(=O)C(C)(C)C)n[nH]c1C(C)C>>Cc1cc(OCc2ccccc2)ccc1Cc1c(O[C@@H]2O[C@H](COC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@H](OC(=O)C(C)(C)C)[C@H]2OC(=O)C(C)(C)C)nn(CCOCc2ccccc2)c1C(C)C,,CC(=O)N(C)C,,O,[H-].[Na+],val
US04208344,CCOC(=O)CC(C)(C)CC(C(=O)OCC)P(=O)(OCC)OCC.CI>>CCOC(=O)CC(C)(C)CC(C)(C(=O)OCC)P(=O)(OCC)OCC,,C1COCCO1,,[H-].[Na+],,val
US20100292276A1,O=C(C=CC1CCCCC1)Nc1ccc(-c2c(F)cccc2C(F)(F)F)cc1[N+](=O)[O-]>>Fc1cccc(C(F)(F)F)c1-c1ccc2[nH]c(C=CC3CCCCC3)nc2c1,[Fe],CC(=O)O,CCO,,,val
US04507498,CCCc1c(O)ccc(C(C)=O)c1O.CCCc1c(OCCCC(=O)OCC)ccc(C(C)=O)c1OCCOCCOCCOCCBr>>CCCc1c(OCCOCCOCCOCCOc2c(C(C)=O)ccc(OCCCC(=O)OCC)c2CCC)ccc(C(C)=O)c1O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US05025025,CC(C)(C)CO.COC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1>>CC(C)(C)COC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1,,C1CCOC1,CCCCCC,[Li]CCCC,,val
US20090312338A1,CCOC(=O)C1CC(=O)CC1CC.c1ccc(CNCc2ccccc2)cc1>>CCOC(=O)C1CC(N(Cc2ccccc2)Cc2ccccc2)CC1CC,,ClCCCl,,CC(=O)O,O=C([O-])O.[Na+],val
US20080275028A1,COc1ccc(N2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)c(OC)c1>>COc1ccc(N2CCN(CCCCN)CC2)c(OC)c1,,CCO,,NN,O,val
US20080021059A1,CCNC(=O)Nc1nc2cc(-c3cccnc3)cc(C(=O)OCC)n2n1>>CCNC(=O)Nc1nc2cc(-c3cccnc3)cc(CO)n2n1,,C1CCOC1,CO,[BH4-].[Na+],,val
US05266570,O=C(O)[C@@]12C[C@@H](c3ccccc31)c1ccc(Cl)cc12.O=S(Cl)Cl>>O=C(Cl)[C@@]12C[C@@H](c3ccccc31)c1ccc(Cl)cc12,,Cc1ccccc1,,,,val
US20150111877A1,C=Cc1cccc(S(=O)(=O)N2C[C@H](C)Oc3ncc(NC(=O)OC(C)(C)C)cc32)c1>>CCc1cccc(S(=O)(=O)N2C[C@H](C)Oc3ncc(NC(=O)OC(C)(C)C)cc32)c1,,CO,,,,val
US03933816,COC(=O)CN1C(=O)CN=C(c2c(F)cccc2F)c2cc(Cl)ccc21.S=P12SP3(=S)SP(=S)(S1)SP(=S)(S2)S3>>COC(=O)CN1C(=S)CN=C(c2c(F)cccc2F)c2cc(Cl)ccc21,,ClCCl,O,c1ccncc1,,val
US20100249123A1,CC(C)(c1ccncc1)c1ccc(N)cc1.COc1ccc(C(=O)Cl)cc1OC>>COc1ccc(C(=O)Nc2ccc(C(C)(C)c3ccncc3)cc2)cc1OC,,ClCCl,,CCN(CC)CC,,val
US20110076291A1,CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CNC3)ccc1-2.O=S(=O)(Cl)CCCl>>C=CS(=O)(=O)N1CC(c2ccc3c(c2)OCCc2sc(-c4ncnn4C(C)C)nc2-3)C1,,ClCCl,,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20080293718A1,Brc1ncccn1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC1(C)OB(c2ncccn2)OC1(C)C,,COCCOC,O,CC(=O)[O-].[K+],,val
US20130123338A1,CCCCC/C=C\C/C=C\CCCCCCCCC(CCCCCCCC/C=C\C/C=C\CCCCC)OC(=O)N(C)CCCOS(C)(=O)=O.CCNCC>>CCCCC/C=C\C/C=C\CCCCCCCCC(CCCCCCCC/C=C\C/C=C\CCCCC)OC(=O)N(C)CCCN(CC)CC,,CCO,ClCCl,,,val
US20110098290A1,COC(=O)c1cc(C(C)C)c(OC)cc1O>>COc1cc(O)c(C(=O)O)cc1C(C)C,,CO,O,[K+].[OH-],,val
US06350749B1,Cc1cn(S(C)(=O)=O)c2c1C(=O)CC(c1cccs1)C2.Cl.N=C(N)NN>>Cc1cn(S(C)(=O)=O)c2c1C(=NNC(=N)N)CC(c1cccs1)C2.Cl,,CCO,,Cl,O,val
US20150329523A1,COCCOCCOCCOCCOCCOc1cc(N)cc(OC)c1.Cc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)cc1>>COCCOCCOCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)C)nn4-c4ccc(C)cc4)c4ccccc34)n2)cc(OC)c1,,CCOC(C)=O,CN(C)C=O,C1CCOC1,,val
US20120059028A1,CC#N.COC(=O)c1ccc(C)cc1OC>>COc1cc(C)ccc1C(=O)CC#N,,C1CCOC1,,Cl,[Li]CCCC,val
US20060094754A1,CC(=O)CC(C)=O.Nc1ccc(OC(F)(F)F)cc1C(=O)c1ccc(Cl)c(Cl)c1>>CC(=O)c1c(C)nc2ccc(OC(F)(F)F)cc2c1-c1ccc(Cl)c(Cl)c1,,CCCCCCC,CCOC(C)=O,,,val
US20060154965A1,O=C(O)CCC(=O)c1ccc(F)cc1.Sc1ccccc1>>O=C(O)CCC(=O)c1ccc(Sc2ccccc2)cc1,,O,,CS(C)=O,O=C([O-])[O-].[K+].[K+],val
US20020019527A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.Cn1cncc1C(N)c1ccc(C#N)c(-c2cccc3ccccc23)c1>>Cn1cncc1C(NC1CCN(C(=O)OC(C)(C)C)CC1)c1ccc(C#N)c(-c2cccc3ccccc23)c1,,CCOC(C)=O,ClCCCl,CC(=O)O,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],val
US03989842,N#CS.Nc1ccc(Cl)c(Cl)c1.O=C(Cl)c1c(Cl)cccc1Cl>>O=C(NC(=S)Nc1ccc(Cl)c(Cl)c1)c1c(Cl)cccc1Cl,,CC(C)=O,O,N,,val
US20080194552A1,Cc1ncc(N)cc1C#Cc1cnc(N)nc1.O=C(O)CCc1ccc(C(F)(F)F)cc1>>Cc1ncc(NC(=O)CCc2ccc(C(F)(F)F)cc2)cc1C#Cc1cnc(N)nc1,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20130079377A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C(C)c1ccc(C#N)cc1>>CCOC(=O)C(C)c1ccc(CNC(=O)OC(C)(C)C)cc1,[Pd],CCO,,,,val
US20090048258A1,CCOc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccc(OCOC)cc3)c3ccccc3n2)cc1OCC>>CCOc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccc(O)cc3)c3ccccc3n2)cc1OCC,,C1CCOC1,,Cl,,val
US05968875,CNC(=O)C(=NOC)c1ccccc1COc1ncc(C(=O)O)cc1Cl.OCC(F)(F)F>>CNC(=O)C(=NOC)c1ccccc1COc1ncc(C(=O)OCC(F)(F)F)cc1Cl,,C1CCOC1,,O,O=C(n1ccnc1)n1ccnc1,val
US07662581B1,CC(C)C(NCCCN1C(=O)c2ccccc2C1=O)c1nc2cc(Br)ccc2n1Cc1ccccc1.O=C(Cl)c1ccc(Cl)cc1>>CC(C)C(c1nc2ccccc2n1Cc1ccccc1)N(CCCN1C(=O)c2ccccc2C1=O)C(=O)c1ccc(Cl)cc1,,CCOC(C)=O,ClCCl,CCN(CC)CC,O=C([O-])O.[Na+],val
US06340679B1,CCOC(=O)CCCOc1ccc(C[C@H](NS(=O)(=O)c2ccc(C)cc2)C(=O)OC(C)(C)C)cc1.NC1=NCCCN1>>Cc1ccc(S(=O)(=O)N[C@@H](Cc2ccc(OCCCC(=O)NC3=NCCCN3)cc2)C(=O)OC(C)(C)C)cc1,,CN(C)C=O,,,,val
US20090233896A1,C1CNCCN1.Cc1ccc(-c2cnc(Nc3cccc(Cl)n3)s2)cn1>>Cc1ccc(-c2cnc(Nc3cccc(N4CCNCC4)n3)s2)cn1,,CCCCO,,CCN(C(C)C)C(C)C,,val
US20110071191A1,Nc1ccc(OC(F)F)nc1.O=C1CCC(=O)N1Br>>Nc1ccc(OC(F)F)nc1Br,,CC#N,,O,,val
US20100035883A1,O=c1[nH]nc2c3c(cccc13)NC(c1ccncc1)C2c1ccncc1>>O=c1[nH]nc2c3c(cccc13)NC(c1ccncc1)C2C1CCNCC1,O=[Pt]=O,,,,,val
US20130072470A1,CC[C@@H]1C[C@@H](CCC#N)C[C@@H]1c1nnc2cnc3c(ccn3S(=O)(=O)c3ccc(C)cc3)n12>>CC[C@@H]1C[C@@H](CCC#N)C[C@@H]1c1nnc2cnc3[nH]ccc3n12,,C1CCOC1,,[Na+].[OH-],,val
US20150111870A1,COc1nc2ccc(Br)cc2c(Cl)c1CBr.FC(F)(F)CN1CCNCC1>>COc1nc2ccc(Br)cc2c(Cl)c1CN1CCN(CC(F)(F)F)CC1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20100076027A1,COC(=O)c1ccc(NC(=O)C(c2c3c(nn2-c2ccc(Cl)cc2)CCCC3)C2CCCCC2)c(Cl)c1>>O=C(O)c1ccc(NC(=O)C(c2c3c(nn2-c2ccc(Cl)cc2)CCCC3)C2CCCCC2)c(Cl)c1,,C1CCOC1,,[Li+].[OH-],,val
US20140045862A1,COc1ccc(CN(c2ccncn2)S(=O)(=O)c2cc(F)c(O[C@H]3CC[C@@H](OCc4ccccc4)C[C@@H]3c3ccnn3C)cc2F)c(OC)c1>>Cn1nccc1[C@H]1C[C@H](OCc2ccccc2)CC[C@@H]1Oc1cc(F)c(S(=O)(=O)Nc2ccncn2)cc1F,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20070197555A1,COC(=N)c1ccccc1O.COC(=O)CC(C)=O.NCCc1ccccc1>>Cc1cc(=O)n(CCc2ccccc2)c(-c2ccccc2O)n1,,CO,,O=C([O-])O.[Na+],,val
US05763451,COc1ccc2nc(OS(=O)(=O)C(F)(F)F)c3c(c2c1)[C@@H](O)C(OC)(OC)C[C@@H]3C>>COc1ccc2ncc3c(c2c1)[C@@H](O)C(OC)(OC)C[C@@H]3C,,C1COCCO1,,CCN(CC)CC,O=CO,val
US05025025,CCOC(=O)C(CCCOC1CCCCO1)CCCC(N)=O>>NCCCCC(CO)CCCOC1CCCCO1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20110015194A1,Nc1ccccc1NCC(F)F.O=C(O)C(=O)c1ccc(Cl)cc1>>O=c1c(-c2ccc(Cl)cc2)nc2ccccc2n1CC(F)F,,CO,,,,val
US20090198063A1,CCOC(=O)CN(Cc1cc2c(cn1)OCCO2)C1CCN(CCn2c(=O)ccc3ncc(OC)cc32)CC1>>COc1cnc2ccc(=O)n(CCN3CCC(N(CC(=O)O)Cc4cc5c(cn4)OCCO5)CC3)c2c1,,C1CCOC1,CO,Cl,[Na+].[OH-],val
US20030212276A1,CCO.N#Cc1cnc2cc(F)c(O)cc2c1Cl>>CCOc1cc2c(Cl)c(C#N)cnc2cc1F,,C1CCOC1,,CCOC(=O)/N=N/C(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US06387692B1,CC(N)c1ccc(Cl)cc1.COCC(=O)OC>>COCC(=O)NC(C)c1ccc(Cl)cc1,,COC(C)(C)C,,,,val
US20150376191A1,C1=Cc2ncccc2Nc2ccccc21>>c1ccc2c(c1)CCc1ncccc1N2,[Pd],C1CCOC1,CO,,,val
US06320017B1,CC(=O)Cl.CCO.[N-]=[N+]=NCCOCCOCCOCCOCC(=O)O>>CCOC(=O)COCCOCCOCCOCCN.Cl,,CCO,,O,,val
US20150239838A1,CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)Nc1cccc(-c2ccccc2Cl)c1F.Cl>>Cl.O=C(Nc1cccc(-c2ccccc2Cl)c1F)[C@@H]1C[C@@H](F)CN1,,C1COCCO1,Cl,,,val
US20160152605A1,O=C(O[C@H]1CCN(C(=O)OCc2ccccc2)[C@H](c2ccc(Cl)nc2)C1)c1ccccc1>>O=C(OCc1ccccc1)N1CC[C@H](O)C[C@H]1c1ccc(Cl)nc1,,CO,ClCCl,O=C([O-])[O-].[K+].[K+],,val
US20030069297A1,Cc1[nH]c(C=O)c(C)c1C(=O)NCCN(C(C)C)C(C)C.O=C1Cc2c(cccc2-c2ccc(Br)cc2)N1>>Cc1[nH]c(C=C2C(=O)Nc3cccc(-c4ccc(Br)cc4)c32)c(C)c1C(=O)NCCN(C(C)C)C(C)C,C1CCNCC1,CCO,,,,val
US05104892,O=[N+]([O-])c1ccc(SCCCCl)cc1>>Nc1ccc(SCCCCl)cc1,,CCO,,[Na+].[OH-],,val
US20120040985A1,CC(C)(c1ccc(Cl)c(Cl)c1)c1c[nH]c(=S)n1-c1ccc(F)cc1.Fc1cccc(Cl)c1CCl>>CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2Cl)n1-c1ccc(F)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US04005073,CC(C)CC(C(=O)O)C(=O)OCc1ccccc1.O=C(Cl)C(=O)Cl>>CC(C)CC(C(=O)O)C(=O)OCc1ccccc1.[Cl-],CN(C)C=O,c1ccccc1,,,,val
US20080004302A1,CC#N.COC(=O)CCc1cccc(NC(=O)OC(C)(C)C)c1.NN>>CC(C)(C)OC(=O)Nc1cccc(CCc2cc(N)n[nH]2)c1,,C1CCOC1,,O,CC(C)[N-]C(C)C.[Li+],val
US20150284395A1,CCOC(=O)CC(=O)c1ccc2c(cnn2CC)c1.Nc1[nH]ncc1-c1nc2ccccc2o1>>CCn1ncc2cc(-c3cc(=O)n4ncc(-c5nc6ccccc6o5)c4[nH]3)ccc21,,c1ccc(Oc2ccccc2)cc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20060194969A1,CNC.COCc1nc2c(NCc3c(C)cccc3C)cc(C(=O)O)cc2n1C>>COCc1nc2c(NCc3c(C)cccc3C)cc(C(=O)N(C)C)cc2n1C,,C1CCOC1,CN(C)C=O,O,,val
US20130143860A1,COC1CNC1.Fc1ccc(Br)cn1>>COC1CN(c2ccc(Br)cn2)C1,,CC(=O)N(C)C,,Cl,O=C([O-])[O-].[K+].[K+],val
US20050009809A1,CC(C)N=C=O.O=C(c1c2ccccc2nc2ccccc12)N1CCN(c2cccc(O)c2)CC1>>CC(C)NC(=O)Oc1cccc(N2CCN(C(=O)c3c4ccccc4nc4ccccc34)CC2)c1,,ClCCl,,CCN(CC)CC,,val
US20100286390A1,CCOC(=O)Cn1ncc(NCc2ccc(OCC)c(OC)c2)c(Br)c1=O>>CCOC(=O)Cn1ncc(N)c(Br)c1=O,,CCO,,Cl,,val
US20110034454A1,CCCC[Sn](CCCC)(CCCC)c1ccccn1.COC(=O)c1cc(N2CCOCC2)nc(Cl)n1>>O=C(O)c1cc(N2CCOCC2)nc(-c2ccccn2)n1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,[Na+].[OH-],,val
US20040097563A1,CC(C)(C)[Si](C)(C)Oc1ccccc1-c1cc(-c2cccc([N+](=O)[O-])c2)c(C#N)c(N)n1>>CC(C)(C)[Si](C)(C)Oc1ccccc1-c1cc(-c2cccc(N)c2)c(C#N)c(N)n1,[Pd],CCOC(C)=O,,,,val
US20150225397A1,CC(C)(C)C(=N)N.C[C@H]1[C@@H]2CC/C(=C/O)C(=O)[C@@]2(c2ccccc2)CCC12OCCO2>>C[C@H]1[C@@H]2CCc3cnc(C(C)(C)C)nc3[C@@]2(c2ccccc2)CCC12OCCO2,,CC(C)O,,C1CCNCC1,Cl,val
US20080015214A1,CN.[C-]#[N+]c1ccc2c(c1)c(C1=CCN([C@H]3Cc4cccc5cccc3c45)CC1)cn2CC1CO1>>[C-]#[N+]c1ccc2c(c1)c(C1=CCN([C@@H]3Cc4cccc5cccc3c45)CC1)cn2CC(O)CNC,,CO,,,,val
US20100261755A1,CCOC(=O)CC(=O)[C@H]1CCN(C(=O)OC)[C@@H](c2cc(F)c(C(F)(F)F)c(F)c2)C1.NO>>COC(=O)N1CC[C@H](c2cc(=O)[nH]o2)C[C@@H]1c1cc(F)c(C(F)(F)F)c(F)c1,,CO,O,Cl,[Na+].[OH-],val
US20120071462A1,CC(=O)ON=C(N)c1ccc(I)cc1>>Cc1nc(-c2ccc(I)cc2)no1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20150057273A1,CC(C)(C)c1cc(N)n(-c2cccc(O)c2)n1.CN(C)CCO>>CN(C)CCOc1cccc(-n2nc(C(C)(C)C)cc2N)c1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20030045546A1,O=[N+]([O-])c1ccc(-c2noc(-c3sccc3Cl)n2)cc1>>Nc1ccc(-c2noc(-c3sccc3Cl)n2)cc1,[Pd],CCO,,,,val
US20120165318A1,CCN(CC)c1nc2cc(C(=O)OC)ccc2nc1-c1ccccc1>>CCN(CC)c1nc2cc(C(=O)O)ccc2nc1-c1ccccc1,,CO,O,Cl,[Na+].[OH-],val
US20110318388A1,C#CCCCCCC.CCOC(=O)CCNC(=O)N1CCc2cc(I)ccc21>>CCCCCCC#Cc1ccc2c(c1)CCN2C(=O)NCCC(=O)OCC,[Cu]I,,,,,val
US20070027139A1,CC(C)(C)OC(=O)N1CCN(c2cccc3cc(C(=O)c4cccc(Cl)c4)cnc23)CC1.Cl>>Cl.O=C(c1cccc(Cl)c1)c1cnc2c(N3CCNCC3)cccc2c1,,C1COCCO1,,,,val
US20120309750A1,CCCC[Sn](CCCC)(CCCC)c1cnn(CC)c1.CCNC(=O)c1noc(-c2cc(C(C)C)c(OCc3ccccc3)cc2OCc2ccccc2)c1I>>CCNC(=O)c1noc(-c2cc(C(C)C)c(OCc3ccccc3)cc2OCc2ccccc2)c1-c1cnn(CC)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20060154929A1,CCBr.Cc1cc(O)ccc1-n1c(C)ccc1C>>CCOc1ccc(-n2c(C)ccc2C)c(C)c1,,CC#N,,O=C([O-])[O-].[K+].[K+],,val
US05753664,Cc1cccc2nc(SCc3ccc(C(=O)c4ccc(O)cc4)cc3)n(C)c(=O)c12.O=C(CBr)c1ccccc1>>Cc1cccc2nc(SCc3ccc(C(=O)c4ccc(OCC(=O)c5ccccc5)cc4)cc3)n(C)c(=O)c12,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05043094,Cc1ccc(S(=O)(=O)O[C@H](C)C[C@@H](C)OS(=O)(=O)c2ccc(C)cc2)cc1.Oc1ccccc1>>C[C@@H](C[C@H](C)Oc1ccccc1)Oc1ccccc1,,CN(C)C=O,,[H-].[Na+],,val
US20080113978A1,CCC(CC)c1cc(C)nn2c(-c3sc(Br)cc3C)c(C)nc12.COCI>>CCC(CC)c1cc(C)nn2c(-c3sc(COC)cc3C)c(C)nc12,,CCOC(C)=O,,C1CCOC1,[Li]CCCC,val
US20050222230A1,CCOc1cccc(-c2ccc(CC(=O)O)cc2)c1.CN(C)C=O.Oc1ccc(Cl)c(O)c1>>CCOc1cccc(-c2ccc(-c3coc4cc(O)c(Cl)cc4c3=O)cc2)c1,,CCCCCC,CCOC(C)=O,ClP(Cl)(Cl)(Cl)Cl,,val
US20040242608A1,C[C@H](N)CO.Cc1ccc(C(=O)O)cc1-n1cnc(OCc2ccc(F)cc2F)c(Br)c1=O>>Cc1ccc(C(=O)N[C@@H](C)CO)cc1-n1cnc(OCc2ccc(F)cc2F)c(Br)c1=O,CN(C)c1ccncc1,CC(=O)N(C)C,,CC(C)COC(=O)Cl,CN1CCOCC1,val
US20150166564A1,CC(C)(C)OC(=O)N[C@H]1CNC[C@@H]1c1cccc(F)c1.O=S(=O)(OCC(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N[C@H]1CN(CC(F)(F)F)C[C@@H]1c1cccc(F)c1,,CN(C)C=O,,CCN(C(C)C)C(C)C,,val
US20150031685A1,CN(C(=O)OC(C)(C)C)[C@H](CN1CC[C@H](O[Si](C)(C)C(C)(C)C)C1)c1cccc(C(F)(F)F)c1>>CN[C@H](CN1CC[C@H](O)C1)c1cccc(C(F)(F)F)c1,,ClCCl,O=C(O)C(F)(F)F,,,val
US06355642B1,CC(=O)Oc1ccc2c3c1CCCC3(CCCCBr)C(=O)N2>>COc1ccc2c3c1CCCC3(CCCCBr)C(=O)N2,,CO,,C[O-].[Na+],,val
US06384065B1,CC(C)CC=C1CCC2(CC1)SC(CC(=O)OC(C)(C)C)C(=O)N2CCC(=O)O.CCI>>CCOC(=O)CCN1C(=O)C(CC(=O)OC(C)(C)C)SC12CCC(=CCC(C)C)CC2,,CCOC(C)=O,CN(C)C=O,Cl,O=C([O-])[O-].[K+].[K+],val
US20130252953A1,O=C(Cl)OCc1ccccc1.O=C(Cn1sc2ccccc2c1=O)N1CCNCC1>>O=C(Cn1sc2ccccc2c1=O)N1CCN(C(=O)OCc2ccccc2)CC1,,CN(C)C=O,ClCCl,CCN(C(C)C)C(C)C,,val
US20110112158A1,Cc1ccc2onc(OC3CCCCO3)c2c1.O=C1CCC(=O)N1Br>>BrCc1ccc2onc(OC3CCCCO3)c2c1,,ClC(Cl)(Cl)Cl,,CC(C)(C#N)N=NC(C)(C)C#N,,val
US20040006099A1,CC(C)(C)OC(=O)N1CCc2ccc(OCC3CCNCC3)cc2C1.O=Cc1cnccc1Cl>>CC(C)(C)OC(=O)N1CCc2ccc(OCC3CCN(c4ccncc4C=O)CC3)cc2C1,,CCO,CCOCC,C1CCOC1,CCN(CC)CC,val
US20070244159A1,COC(C)(C)OC.N#CCc1ccc(O)c(O)c1>>CC1(C)Oc2ccc(CC#N)cc2O1,,Cc1ccccc1,,Cc1ccc(S(=O)(=O)O)cc1,,val
US20080004271A1,CS(=O)c1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(C(N)=O)sc2n1.NCCCCO>>NC(=O)c1sc2nc(NCCCCO)nc(-c3ccc(Cl)c(Cl)c3)c2c1N,,C1CCOC1,,CCN(CC)CC,,val
US20060128807A1,CS(=O)(=O)Cl.Cc1cc(-c2ccc(C(=O)OCc3ccccc3)cc2)cc(C)c1OCCO>>Cc1cc(-c2ccc(C(=O)OCc3ccccc3)cc2)cc(C)c1OCCOS(C)(=O)=O,,CCOC(C)=O,ClCCl,CCN(CC)CC,O,val
US20150210630A1,CON=C(CNC(=O)c1ccccc1C(F)(F)F)c1ncc(Br)cc1Cl>>CO/N=C(/CNC(=O)c1ccccc1C(F)(F)F)c1ncc(Br)cc1Cl,,CC#N,,,,val
US20050107423A1,O=C(OCc1ccccc1)N1CC2CCC(O)(COCc3ccccc3)C2C1>>OCC1(O)CCC2CNCC21,[Pd],CCO,CO,[H][H],,val
US04233299,COC(=O)C1=C(O)c2ccc(F)cc2S(=O)(=O)N1C.Cc1cnc(N)s1>>Cc1cnc(NC(=O)C2=C(O)c3ccc(F)cc3S(=O)(=O)N2C)s1,,Cc1ccccc1C,,,,val
US20070270475A1,CC(C)(C)OC(=O)C(Cc1cscn1)N=C(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)C(N)Cc1cscn1,,C1CCOC1,O,O=C(O)CC(O)(CC(=O)O)C(=O)O,,val
US07179823B1,CCOC(=O)CCc1c[nH]nc1OCC.Cc1oc(-c2ccccc2)nc1COc1ccccc1CCl>>CCOC(=O)CCc1cn(Cc2ccccc2OCc2nc(-c3ccccc3)oc2C)nc1OCC,,O,,CN(C)C=O,[H-].[Na+],val
US20060079687A1,CCCN1Cc2cc(Oc3cccc(C(=O)Cl)c3)ccc2N=C1N.Cc1cc(C)c(CN)c(C)c1>>CCCN1Cc2cc(Oc3cccc(C(=O)NCc4c(C)cc(C)cc4C)c3)ccc2N=C1N,,ClCCl,O,,,val
US20150080438A1,CC(=O)SCCCC(F)(F)C(F)(F)F.O=C1c2ccccc2C(=O)N1CCCBr>>O=C1c2ccccc2C(=O)N1CCCSCCCC(F)(F)C(F)(F)F,,CO,,C[O-].[Na+],,val
US20090054508A1,Cc1cc([N+](=O)[O-])sc1C(=O)Nc1ccccc1/C=C/c1n[nH]c2ccccc12>>Cc1cc(N)sc1C(=O)Nc1ccccc1/C=C/c1n[nH]c2ccccc12,[Fe],O,,CCO,[Cl-].[NH4+],val
US20080096930A1,N#Cc1ccc(Br)cn1.OCc1cccc(S)c1>>N#Cc1ccc(Sc2cccc(CO)c2)cn1,,CCOC(C)=O,CN(C)C=O,O=C([O-])O.[Na+],,val
US20090312338A1,Cc1ccc(S(=O)(=O)n2ccc3c2ncc2cnn(C)c23)cc1.II>>Cc1ccc(S(=O)(=O)n2c(I)cc3c4c(cnc32)cnn4C)cc1,,C1CCOC1,O,CC(C)NC(C)C,[Li]CCCC,val
US20090048276A1,CN(C)C=O.ClCCl.O=C(O)Cc1cccc(I)c1>>CCOC(=O)Cc1cccc(I)c1,,ClCCl,,O=C(Cl)C(=O)Cl,,val
US20020151561A1,COc1ccc(CN2CCc3c(sc(N)c3C(=O)OC(C)(C)C)C2CN)cc1.O=C(Cl)c1ccccc1>>COc1ccc(CN2CCc3c(sc(N)c3C(=O)OC(C)(C)C)C2CNC(=O)c2ccccc2)cc1,,CCN(CC)CC,ClCCl,,,val
US04841045,CC(C)(C)[Si](C)(C)Cl.CCCC(CO)CCC#N>>CCCC(CCC#N)CO[Si](C)(C)C(C)(C)C,CN(C)c1ccncc1,ClCCl,,CCN(C(C)C)C(C)C,,val
US20080221096A1,COc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2c1CCC(C)(C)C2>>CC1(C)CCc2c(O)nc3oc4c(NCCN5CCOCC5)ncnc4c3c2C1,,O,,[Na+].[OH-],,val
US20050209253A1,CCOC(=O)C1CCNCC1.Cc1cc(OS(=O)(=O)C(F)(F)F)c2c(C)cn(-c3c(C)cc(Cl)cc3C)c2n1>>CCOC(=O)C1CCN(c2cc(C)nc3c2c(C)cn3-c2c(C)cc(Cl)cc2C)CC1,,O,,CCN(C(C)C)C(C)C,,val
US20030186984A1,CN(c1ncc(Br)cn1)[C@@H]1CC[C@@H](C#CCO)CC1.CS(=O)(=O)Cl>>CN(c1ncc(Br)cn1)[C@@H]1CC[C@@H](C#CCOS(C)(=O)=O)CC1,CN(C)c1ccncc1,ClCCl,,O,c1ccncc1,val
US03953595,O=C(CCl)c1ccccc1.O=C(O)c1cc(S)cc(C(F)(F)F)c1>>O=C(O)c1cc(SCC(=O)c2ccccc2)cc(C(F)(F)F)c1,,O,,CCO,[Na+].[OH-],val
US20120061620A1,C=CCBr.CC(C)[SiH](CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(C)C>>CC(C)[Si](Br)(CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(C)C,Cl[Pd]Cl,c1ccccc1,,,,val
US20090264399A1,CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(Cl)ccnc21.CCOC(=O)Cl>>CCOC(=O)c1cnc2[nH]ccc2c1Cl,,C1CCOC1,,[Li]C(C)CC,,val
US04617314,CC1Cc2cc(S(N)(=O)=O)cc(C(=O)O)c2O1.CCN1CCCC1CN>>CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc2c1OC(C)C2,,CC(C)=O,CN(C)C=O,CCN(CC)CC,CCOC(=O)Cl,val
US20130156705A1,C#CCBr.CC(=O)CC(C)=O>>C#CCC(C(C)=O)C(C)=O,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20080103129A1,Nc1cccnc1Br.O=S(=O)(Cl)c1ccc(Oc2ccccc2)cc1>>O=S(=O)(Nc1cccnc1Br)c1ccc(Oc2ccccc2)cc1,,CCOC(C)=O,c1ccncc1,,,val
US04906402,CI.COC(=O)Cc1ccc(O[Si](C)(C)C)cc1>>COC(=O)C(C)c1ccc(O)cc1,,COCCOC,,,,val
US20110021425A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C1CNCCC1C>>CCOC(=O)C1CN(C(=O)OC(C)(C)C)CCC1C,CN(C)c1ccncc1,C1CCOC1,,,,val
US20060293319A1,O=C(Cl)N1CCOCC1.O=C1Nc2cc(Cl)ccc2C1(Cc1cccc(Cl)c1)C1CCCNC1>>O=C(N1CCOCC1)N1CCCC(C2(Cc3cccc(Cl)c3)C(=O)Nc3cc(Cl)ccc32)C1,,C1CCOC1,,CCN(CC)CC,,val
US20070105913A1,CCCCCC(=O)N(Cc1ccc(C#Cc2ccc(CCCC)cc2)cc1)c1ccc2c(c1)OC(C)(C)OC2=O>>CCCCCC(=O)N(Cc1ccc(C#Cc2ccc(CCCC)cc2)cc1)c1ccc(C(=O)O)c(O)c1,,C1CCOC1,,,,val
US05880147,CC(C)(C)C(N)=O.CCCCCC(CC(=O)Nc1cc(C(=O)O)ccc1C(C)(C)C)c1ccc(OC)cc1OC>>CCCCCC(CC(=O)Nc1cc(C(=O)NC(=O)C(C)(C)C)ccc1C(C)(C)C)c1ccc(OC)cc1OC,,CCOC(C)=O,,,,val
US20110230486A1,CN1CCNCC1.Cc1cc(C)c(-c2csc(NC(=O)c3ccnc(Cl)c3)n2)c(C)c1>>Cc1cc(C)c(-c2csc(NC(=O)c3ccnc(N4CCN(C)CC4)c3)n2)c(C)c1,,CN1CCCC1=O,,O,,val
US20050107579A1,C1CCOC1.CSc1ccc(Br)cc1.ClP(c1ccccc1)c1ccccc1>>CSc1ccc(CP(c2ccccc2)c2ccccc2)cc1,,C1CCOC1,,[Li]CCCC,,val
US20140249126A1,CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(CCl)CS[C@H]23)c(Cl)s1.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(CCl)C[S@@](=O)[C@H]23)c(Cl)s1,,ClCCl,,O=S([O-])([O-])=S.[Na+].[Na+],,val
US06844351B1,CCCCNCC.Cc1nc(Cl)cc(Cl)n1>>CCCCNCCc1cc(Cl)nc(C)n1,,CC#N,O,,,val
US20070244131A1,COc1nc(Cl)cc(Cl)n1.NCCc1ccc(Cl)cc1>>COc1nc(Cl)cc(NCCc2ccc(Cl)cc2)n1,,CCO,,O,O=C([O-])O.[Na+],val
US04512999,C=S1C2C(=O)C(=O)N2C(C(=O)O)C1(C)C.CC(C)(C)C(=O)O.O=C(C=P(c1ccccc1)(c1ccccc1)c1ccccc1)COc1ccccc1>>C=S1[C@@H]2C(=CC(=O)COc3ccccc3)C(=O)N2[C@@H](C(=O)O)C1(C)C.CC(C)(C)C(=O)O,,c1ccccc1,,,,val
US20100249114A1,CN1CCC(N2CCNCC2)CC1.O=C(O)[C@@H](Cc1ccc(Br)c(Br)c1)OC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1>>CN1CCC(N2CCN(C(=O)[C@@H](Cc3ccc(Br)c(Br)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1,,CN(C)C=O,,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20020103199A1,Nc1nc2ccccc2[nH]1.O=C(O)C(CC1CCCC1)c1ccc(Cl)c(Cl)c1>>O=C(Nc1nc2ccccc2[nH]1)C(CC1CCCC1)c1ccc(Cl)c(Cl)c1,,ClCCl,O,CCN(CC)CC,CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F,val
US20050288273A1,CCOC(=O)Cl.COC(=O)OC1CCCCc2cc(N)cnc21>>CCOC(=O)Nc1cnc2c(c1)CCCCC2OC(=O)OC,,ClCCl,,c1ccncc1,,val
US20100144805A1,COC(=O)C(Cc1ccccc1)NC(=O)c1nc(-c2ccccc2)cs1>>O=C(NC(Cc1ccccc1)C(=O)O)c1nc(-c2ccccc2)cs1,,CCO,,[K+].[OH-],,val
US20070113930A1,CC(Br)C(=O)c1ccc(Cl)cc1Cl.N=C(N)c1ccccc1>>Cc1[nH]c(-c2ccccc2)nc1-c1ccc(Cl)cc1Cl,,C1CCOC1,,Cl,C[O-].[Na+],val
US20110003836A1,Brc1ccc2[nH]c3ccc(Br)cc3c2c1.C1CCOC1>>Brc1ccc2c(c1)c1cc(Br)ccc1n2C[C@H]1CO1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110213145A1,CN(C)C=O.CN(C)C[C@@H](N)Cc1cccs1.c1ccc(-c2ccccc2)cc1>>NC(=O)c1ccccc1-c1ccccc1,,CCOC(C)=O,CN(C)C=O,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,,val
US20110319359A1,CC[Mg]Br.N#CCC1Cc2ccccc2C1>>NC1(CC2Cc3ccccc3C2)CC1,CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C,,,,,val
US06251925B1,COC(=O)c1cccc(Br)c1.O=[N+]([O-])c1cccc(B(O)O)c1>>COC(=O)c1cccc(-c2cccc([N+](=O)[O-])c2)c1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,,,,,val
US20110144105A1,COCc1cnc2[nH]c(C(=CC3CCCC3)c3ccc(S(C)(=O)=O)cc3)cc2c1>>COCc1cnc2[nH]c(C(CC3CCCC3)c3ccc(S(C)(=O)=O)cc3)cc2c1,[Pd],CO,,,,val
US20050020503A1,COc1cc([N+](=O)[O-])ccc1C>>COc1ccc(C)c(N)c1,[Pd],,,CCO,,val
US05071844,COc1ccc(CCBr)cc1.C[C@@]1(C(=O)O)CCCN1>>COc1ccc(CCN2CCC[C@@]2(C)C(=O)O)cc1,,CC(=O)O,CCO,Cl,O=C([O-])[O-].[Na+].[Na+],val
US20080221195A1,CCn1cc(C[C@@H](N)C(=O)OC)c2ccccc21.COc1ccccc1C#Cc1ccc(OC(C)C)c(C(=O)O)c1>>CCn1cc(C[C@@H](NC(=O)c2cc(C#Cc3ccccc3OC)ccc2OC(C)C)C(=O)OC)c2ccccc21,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080300266A1,CC(C)(C)OC(=O)N[C@H]1CCNC1.Clc1ncc(Br)cn1>>CC(C)(C)OC(=O)N[C@H]1CCN(c2ncc(Br)cn2)C1,,CC#N,,CCN(C(C)C)C(C)C,ClCCl,val
US04997847,CCOC(=O)CC(C)(C)CCNS(=O)(=O)c1ccccc1>>CC(C)(CCNS(=O)(=O)c1ccccc1)CC(=O)O,,CO,,[Na+].[OH-],,val
US04267180,O=C(CN1CCCC1=O)Nc1ccc(-c2ncc(C(=O)O)c(O)n2)cc1.O=C(n1ccnc1)n1ccnc1>>O=C(CN1CCCC1=O)Nc1ccc(-c2ncc(C(=O)O)c(O)n2)cc1.c1c[n-]cn1,,ClCCl,,CC(=O)N(C)C,,val
US20050148623A1,CC[C@H](C)[C@H](NCCN)C(=O)OC(C)(C)C.O=C(Oc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1>>CC[C@H](C)[C@@H](C(=O)OC(C)(C)C)N1CCNC1=O,,ClCCCl,,,,val
US20090054407A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc2[nH]ccc2c1>>CC(C)(C)OC(=O)Nc1ccc2c(ccn2C(=O)OC(C)(C)C)c1,CN(C)c1ccncc1,CC#N,,,,val
US04894386,CCCN.CCCn1cc(Cc2ccc(C(=O)OC)cc2OC)c2cc(C3OC(=O)CC3C(=O)O)ccc21>>CCCNC(=O)CC(C(=O)O)C(O)c1ccc2c(c1)c(Cc1ccc(C(=O)OC)cc1OC)cn2CCC,,CCOC(C)=O,ClCCl,CCN(CC)CC,,val
US05504076,CNN.O=C(Cl)c1ccccc1>>CN(N)C(=O)c1ccccc1,,ClCCl,,,,val
US20050020559A1,CCC1=C(C)c2cc3[nH]c(cc4nc(c(C(O)C(=O)OC)c5[nH]c(cc1n2)c(C)c5C(=O)NCCOCCO)C(CCC(=O)OC)C4C)c(C)c3C=O>>CCC1=C(C)c2cc3[nH]c(cc4nc(c(C(O)C(=O)OC)c5[nH]c(cc1n2)c(C)c5C(=O)NCCOCCO)C(CCC(=O)OC)C4C)c(C)c3CO,,ClCCl,,,,val
US04894383,CCCC(C)(C)C1(CCc2ccc(Cl)cc2)CO1.c1nc[nH]n1>>CCCC(C)(C)C(O)(CCc1ccc(Cl)cc1)Cn1cncn1,,CN1CCCC1=O,,O,[Na+].[OH-],val
US20140088124A1,COC(=O)C(C)(C)COc1ccncc1>>COC(=O)C(C)(C)COC1CCNCC1,[Rh],CC(=O)O,,,,val
US20020006920A1,COc1ccc(S(=O)(=O)NC(C)(C)C(=O)OCc2ccccc2)cc1>>COc1ccc(S(=O)(=O)NC(C)(C)C(=O)O)cc1,[Pd],CCO,,,,val
US04623662,CCCCNC(=O)c1ccccc1Cl>>CCCCNCc1ccccc1Cl,,C1CCOC1,,B,Cl,val
US03953398,CCCC(C)(C)c1cc(C=O)cc(C(C)(C)CCC)c1O.N#CCC(=O)O>>CCCC(C)(C)c1cc(C=CC#N)cc(C(C)(C)CCC)c1O,,O,c1ccncc1,C1CCNCC1,Cl,val
US20050137226A1,Brc1cnc(Oc2ccc(OC3CN4CCC3CC4)cc2)nc1.O=C(O)C(F)(F)F>>Brc1cnc(Oc2ccc(OC3CN4CCC3CC4)cc2)nc1.O=C(O)C(F)(F)F,,CCOC(C)=O,,,,val
US20120083482A1,CN(C(=O)CC(=O)O)c1ccccc1.CN(C)CC/C=C\c1cc2nccc(Oc3ccc(N)cc3F)c2s1>>CN(C)CC/C=C\c1cc2nccc(Oc3ccc(NC(=O)CC(=O)N(C)c4ccccc4)cc3F)c2s1,,CCOC(C)=O,CN(C)C=O,ClCCCl,,val
US20030236247A1,CC(C)(C)OC(=O)N1CC=C(OC(=O)C(F)(F)F)CC1.OB(O)c1ccc(F)cc1>>CC(C)(C)OC(=O)N1CC=C(c2ccc(F)cc2)CC1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CO,COCCOC,[Cs+].[F-],,val
US20160083387A1,C/C=C1\CC[C@H]2[C@H](CN)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@]12C>>CC[C@H]1CC[C@H]2[C@H](CN)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@]12C,[Pd],CCOC(C)=O,CO,CC(=O)O,,val
US20100197619A1,C=O.O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12.OCCN1CCNCC1>>O=c1cc(-c2ccccc2)oc2c(CN3CCN(CCO)CC3)c(O)c(O)c(O)c12,,CO,,,,val
US20100120874A1,COc1cc(N)ccc1-n1cnc(C)c1.O=C(N=C=S)c1ccccc1>>COc1cc(NC(N)=S)ccc1-n1cnc(C)c1,,C1CCOC1,O,O=C([O-])[O-].[K+].[K+],,val
US20090124616A1,COC(=O)c1cc2c(-c3ccccc3C)cccc2[nH]1.O=C1CCC(=O)N1Br>>COC(=O)c1[nH]c2cccc(-c3ccccc3C)c2c1Br,,C1CCOC1,ClCCl,,,val
US05030640,C[C@@H](N)CCc1c[nH]c2ccccc12.c1cc2nnnn2cc1[C@@H]1CO1>>C[C@H](CCc1c[nH]c2ccccc12)NC[C@H](O)c1ccc2nnnn2c1,,CCO,,,,val
US20060189657A1,CCC(NC(=O)OC(C)(C)C)C(O[Si](C)(C)C)c1cc(C(C)C)on1.Cl>>CCC(N)C(O)c1cc(C(C)C)on1.Cl,,C1COCCO1,ClCCl,,,val
US20090324569A1,CCNC(=O)Nc1ccc(Sc2ccc(OC)c(-c3cccc(Cl)c3)c2)cc1.OO>>CCNC(=O)Nc1ccc(S(=O)c2ccc(OC)c(-c3cccc(Cl)c3)c2)cc1,,CC(=O)O,,,,val
US20120322841A1,CC1(C)CC(c2ccc(C#N)cc2F)CC1=O.CN.NN>>CC1(C)CC(c2ccc(C#N)cc2F)c2cn[nH]c21,,CC(C)O,,CC(=O)O,O,val
US20120232272A1,CCOC(OCC)C(=O)Cc1ccc(O[Si](C)(C)C(C)(C)C)cc1.Nc1nc2ccc3cc(O)ccc3c2nc1Cc1ccccc1>>O=c1c(Cc2ccc(O)cc2)nc2c(Cc3ccccc3)[nH]c3c4ccc(O)cc4ccc3n1-2,,CCO,O,Cl,,val
US20110076292A1,CC(C)(C)OC(=O)NC1(C(=O)O)CC1.CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(C3CNC3)cc1OCC2>>CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(C3CN(C(=O)C4(N)CC4)C3)cc1OCC2,,O,,CO,Cl,val
US05705516,CC(=O)Nc1nc(C)c(S(=O)(=O)Cl)s1.CCNCC>>CCN(CC)S(=O)(=O)c1sc(NC(C)=O)nc1C,,C1CCOC1,,,,val
US20150051262A1,COc1cccc(CC2(C(=O)N[C@H](C(N)=O)[C@@H](C)O)CCCN2C(=O)[C@@H]2CCCN2C(=O)OCc2ccccc2)c1>>COc1cccc(CC2(C(=O)N[C@H](C(N)=O)[C@@H](C)O)CCCN2C(=O)[C@@H]2CCCN2)c1,[Pd],CO,,,,val
US05545669,O=[N+]([O-])c1cc(C(F)(F)F)ccc1F.Oc1ccccc1OCc1ccccc1>>O=[N+]([O-])c1cc(C(F)(F)F)ccc1Oc1ccccc1OCc1ccccc1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20080085890A1,CN(CCN1CCCC1)c1ccc([N+](=O)[O-])cc1>>CN(CCN1CCCC1)c1ccc(N)cc1,[Pd],C1CCOC1,CCO,O=C(O)C(F)(F)F,,val
US20070225292A1,CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)O.[NH4+]>>CC(C)(C)OC(=O)N1CCCC[C@@H]1C(N)=O,,CN(C)C=O,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20080269268A1,C[Si](C)(C)CCOCn1ccc2c(Nc3ccc([N+](=O)[O-])cc3F)ccnc21>>C[Si](C)(C)CCOCn1ccc2c(Nc3ccc(N)cc3F)ccnc21,O=[Pt]=O,C1CCOC1,CCO,,,val
US20060148842A1,CC1=CNC(=O)C2C(C)CCC12.CCCI>>CCCN1C=C(C)[C@H]2CC[C@H](C)[C@H]2C1=O,,C1CCOC1,,,,val
US20090247559A1,Cl.NC(=O)c1oc2ccc(Br)cc2c1NC(=O)C1CCCCN1>>Cl.O=c1[nH]c(C2CCCCN2)nc2c1oc1ccc(Br)cc12,,CCO,,Cl,[Na+].[OH-],val
US04045442,NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21.O=C(Cl)CCCCCl>>O=C(CCCCCl)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21,,CC#N,,O=C([O-])O.[Na+],,val
US20050054670A1,CC(C)(C)c1ccc(N)cc1.O=C(O)c1cccc([N+](=O)[O-])c1C(=O)O>>CC(C)(C)c1ccc(N2C(=O)c3cccc([N+](=O)[O-])c3C2=O)cc1,,Clc1ccccc1Cl,,,,val
US04377522,CN1C(=O)C(C)(C)N=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21>>CN1C(=O)C(C)(C)N=C(c2ccccc2F)c2cc(N)ccc21,,Cl,,Cl[Sn]Cl,,val
US05500443,BrCCBr.COc1cccc(O)c1O>>COc1cccc2c1OCCO2,[Cu],OCC(O)CO,,O,O=C([O-])[O-].[K+].[K+],val
US04213991,COc1ccc(CCC(Cl)Cn2ccnc2)cc1.Sc1ccccc1Cl>>COc1ccc(CCC(Cn2ccnc2)Sc2ccccc2Cl)cc1,,CC(C)=O,,Cl,O=C([O-])[O-].[K+].[K+],val
US20120259123A1,CCCCC(C)(C)c1ccc(CNC(c2cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)S(=O)(=O)c2cccc(F)c2)cc1>>CCCCC(C)(C)c1ccc(CNC(c2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1,,ClCCl,,O=C(O)C(F)(F)F,,val
US20090312381A1,CC(C)(NC(=O)Cn1nc(-c2ccc(Cl)cc2)[nH]c1=O)c1cccc(C(F)(F)F)c1.FC(F)(F)C1CO1>>CC(C)(NC(=O)Cn1nc(-c2ccc(Cl)cc2)n(CC(O)C(F)(F)F)c1=O)c1cccc(C(F)(F)F)c1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20100286129A1,BrBr.COc1cccc(-c2nc3cc(C(C)=O)ccc3n2CC(C)C)c1.Cl>>COc1cccc(-c2nc3cc(C(=O)CBr)ccc3n2CC(C)C)c1.Cl,,CC(=O)O,,CCOCC,,val
US20160243125A1,N#Cc1cccc([N+](=O)[O-])c1.NO>>N/C(=N\O)c1cccc([N+](=O)[O-])c1,,CCOC(C)=O,c1ccncc1,Cl,,val
US20070106080A1,FC(F)(F)C(Cl)=Nc1ccc(Cl)cc1.[N-]=[N+]=[N-]>>FC(F)(F)c1nnnn1-c1ccc(Cl)cc1,,Cc1ccccc1,,CCN(CC)CC,Cl,val
US04910201,O=c1c(Cl)c(Cl)cnn1-c1ccc(Cl)cc1F.OCc1ccc(Cl)cc1>>O=c1c(Cl)c(OCc2ccc(Cl)cc2)cnn1-c1ccc(Cl)cc1F,,CN(C)C=O,,[K+].[OH-],,val
US04994459,C=CCOc1ccc(N)cc1.CS(=O)(=O)Cl>>C=CCOc1ccc(NS(C)(=O)=O)cc1,,c1ccncc1,,,,val
US20020052504A1,O=C(Cl)c1ccccc1.O=C(Nc1ccc(OC2CC2)c(CO)c1)C(F)(F)F>>O=C(OCc1cc(NC(=O)C(F)(F)F)ccc1OC1CC1)c1ccccc1,,ClCCl,,c1ccncc1,O=C([O-])O.[Na+],val
US04281000,CCOC(=O)c1c(N)n[nH]c1CC.CN(C)C=CC(=O)c1cccnc1>>CCOC(=O)c1c(CC)nn2c(-c3cccnc3)ccnc12,,CC(=O)O,,,,val
US20090048203A1,CC(C)N=C=O.Nc1nc(OC2CCCC2)nc2c1ncn2[C@@H]1O[C@H](CF)[C@H](Br)[C@H]1O>>CC(C)NC(=O)O[C@@H]1[C@@H](Br)[C@@H](CF)O[C@H]1n1cnc2c(N)nc(OC3CCCC3)nc21,,CN(C)C=O,,CCN(CC)CC,,val
US20040019063A1,Cc1c(N2C(=O)N3CC[C@@H](O[Si](C)(C)C(C)(C)C)[C@]3(C)C2=O)ccc(C#N)c1Cl>>Cc1c(N2C(=O)N3CC[C@@H](O)[C@]3(C)C2=O)ccc(C#N)c1Cl,,C1CCOC1,,ClCCl,O=C([O-])O.[Na+],val
US20150133428A1,CCOC(=O)C1(C)CC2(C1)CC2(F)F>>CC1(C(=O)O)CC2(C1)CC2(F)F,,C1CCOC1,O,[Na+].[OH-],,val
US20100286171A1,Cn1ccc(NC(=O)/C(=C/[C@H]2CCC(=O)C2)c2ccc(S(=O)(=O)C3CC3)c(C3CC3)c2)n1>>Cn1ccc(NC(=O)/C(=C/[C@H]2CCC(O)C2)c2ccc(S(=O)(=O)C3CC3)c(C3CC3)c2)n1,,CCO,ClC(Cl)Cl,O,[BH4-].[Na+],val
US20160002185A1,BrCc1ccccc1.CCC[C@H](C(=O)OCC)N1C(=O)CO[C@@H](c2ccc(Cl)cc2)[C@H]1c1ccc(Cl)cc1>>CCC[C@H](C(=O)OCC)N1C(=O)[C@H](Cc2ccccc2)O[C@@H](c2ccc(Cl)cc2)[C@H]1c1ccc(Cl)cc1,,C1CCOC1,,C[Si](C)(C)[N-][Si](C)(C)C.[Li+],,val
US20120035237A1,BrCCc1ccccc1.O=C(Nc1c(F)cccc1F)c1ccn(Cc2cc(Cl)ccc2O)n1>>O=C(Nc1c(F)cccc1F)c1ccn(Cc2cc(Cl)ccc2OCCc2ccccc2)n1,,CN(C)C=O,CO,O=C([O-])[O-].[K+].[K+],,val
US20160185775A1,CCCC(C)(CNC(=O)c1c(C)nn2c(O)cc(C)cc12)NC(=O)OC(C)(C)C.Fc1cccnc1CBr>>CCCC(C)(CNC(=O)c1c(C)nn2c(OCc3ncccc3F)cc(C)cc12)NC(=O)OC(C)(C)C,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US04226773,CC(=O)N1CCN=C1Nc1cc(C)nn1-c1ccc(Cl)cc1C.Cl>>Cc1cc(NC2=NCCN2)n(-c2ccc(Cl)cc2C)n1.Cl,,CO,,,,val
US20100210704A1,CC(=O)Nc1cc(OC(F)(F)C(F)OC(F)(F)F)nn1-c1cc(SCC(F)(F)F)c(C)cc1F.O=C(OO)c1cccc(Cl)c1>>CC(=O)Nc1cc(OC(F)(F)C(F)OC(F)(F)F)nn1-c1cc(S(=O)CC(F)(F)F)c(C)cc1F,,ClC(Cl)Cl,,,,val
US20100260710A1,COC(=O)[C@@H]1C[C@H](O)CCN1C(=O)OCc1ccccc1.COc1ccc2c(O)cc(-c3nc(C(F)(F)F)cs3)nc2c1C>>COC(=O)C1CC(Oc2cc(-c3nc(C(F)(F)F)cs3)nc3c(C)c(OC)ccc23)CCN1C(=O)OCc1ccccc1,,C1CCOC1,,CC(C)OC(=O)/N=N/C(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100286103A1,Cc1cc(C=O)sc1Br.[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1>>CC1=CCSC1(Br)c1cnco1,,CO,,O=C([O-])[O-].[K+].[K+],,val
US20150336949A1,CC(C)(C)OC(=O)N1CC=C(c2ccc(Br)cc2[N+](=O)[O-])CC1>>CC(C)(C)OC(=O)N1CC=C(c2ccc(Br)cc2N)CC1,[Zn],C1CCOC1,O,[Cl-].[NH4+],,val
US20020156079A1,Cc1c(C)n(C[C@H]2C[C@@H]2C)c2c(=O)[nH]ncc12.O=P(Cl)(Cl)Cl>>Cc1c(C)n(C[C@H]2C[C@@H]2C)c2c(Cl)nncc12,,O,,[Na+].[OH-],,val
US20140094474A1,CC(C)=Cn1ccc(C(=O)O)n1.C[C@H](N)Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1>>CC(C)=Cn1ccc(C(=O)N[C@@H](C)Cn2ccc(-c3cc(F)c(C#N)c(Cl)c3)n2)n1,,ClCCl,,,,val
US04400202,CC(C)(CC(=O)O)C(=O)O.Nc1cccc([N+](=O)[O-])c1>>CC1(C)CC(=O)N(c2cccc([N+](=O)[O-])c2)C1=O,,Cc1ccccc1C,,,,val
US05604229,CCCCC(=O)Cl.CCCCCCCCCCCCCCCCCCC(N)(COC(C)=O)COC(C)=O>>CCCCCCCCCCCCCCCCCCC(COC(C)=O)(COC(C)=O)NC(=O)CCCC,,CCOC(C)=O,CCOCC,CN(C)c1ccccc1,,val
US20150210682A1,CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2CC.COCCCBr>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCCOC)cc1CC2CC,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US05994368,COCOc1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl>>Cc1ccc2cccc(OCc3c(Cl)ccc(O)c3Cl)c2n1,,CO,,Cl,,val
US20030130518A1,COCCc1nc2c(N)nc3c(c2n1CCOCCN)CCCC3.O=C=Nc1ccccc1>>COCCc1nc2c(N)nc3c(c2n1CCOCCNC(=O)Nc1ccccc1)CCCC3,,ClCCl,,CCN(CC)CC,,val
US04451476,Cc1cc(CCCCCBr)no1.N#Cc1ccc(O)cc1>>Cc1cc(CCCCCOc2ccc(C#N)cc2)no1,,CC#N,,[I-].[K+],,val
US20130210704A1,CN1CCN(CCCCl)CC1.NC(N)=S>>CN1CCN(CCCS)CC1,,CCO,O,[Na+].[OH-],,val
US20020147338A1,CCC(CC)CC#N.CCOC(=O)CC>>CCC(=O)C(C#N)C(CC)CC,,C1CCOC1,CCCCCC,CC(C)NC(C)C,[Li]CCCC,val
US20050107608A1,CO.O=c1c2ccccc2cc(Br)c2ccccc12>>COc1cc2ccccc2c(=O)c2ccccc12,,C1COCCO1,,[K],,val
US20070043066A1,CC(C)(C)OC(=O)CCC(NC(=O)c1ccc(-c2ccc(NC(=O)Cc3ccccc3)cc2)cc1)C(=O)OC(C)(C)C>>O=C(O)CC[C@H](NC(=O)c1ccc(-c2ccc(NC(=O)Cc3ccccc3)cc2)cc1)C(=O)O,,CC(Cl)Cl,,O=C(O)C(F)(F)F,,val
US20110065691A1,CCOC(=O)CC(=O)N1CCN(c2ccc(OC)c(OC3CCCC3)c2)C[C@@H]1Cc1ccccc1>>COc1ccc(N2CCN(CCCO)[C@@H](Cc3ccccc3)C2)cc1OC1CCCC1,,C1CCOC1,,[Al+3].[H-].[H-].[H-].[H-].[Li+],,val
US20130053380A1,COC(=O)c1ccccc1CCCC(Cc1ccccc1)N=[N+]=[N-]>>COC(=O)c1ccccc1CCCC(N)Cc1ccccc1,[Pd],CO,,,,val
US20140094474A1,C#CC(O)C(C)C.CCOC(=O)/C(Cl)=N\O>>CCOC(=O)c1cc(C(O)C(C)C)on1,,CCOC(C)=O,Cc1ccccc1,CCN(CC)CC,,val
US20100273764A1,C1CSCCN1.Fc1ccc(CBr)cn1>>Fc1ccc(CN2CCSCC2)cn1,,CN(C)C=O,,O=C([O-])[O-].[K+].[K+],,val
US20110190255A1,CCOC(=O)[C@H]1CCCN(C[C@@H](O[Si](C)(C)C(C)(C)C)c2ccc(/C(N)=N/O)cc2)C1.O=C(Cl)c1onc(-c2ccccc2)c1C(F)(F)F>>CCOC(=O)[C@H]1CCCN(C[C@@H](O[Si](C)(C)C(C)(C)C)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20070105904A1,CCCC[SnH](CCCC)CCCC.ClCc1ccc(OCc2ccccc2)cc1>>CCCC[Sn](CCCC)(CCCC)Cc1ccc(OCc2ccccc2)cc1,,C1CCOC1,,CC(C)NC(C)C,[Li]CCCC,val
US20070054916A1,Nc1cccc(-c2ccc3ncnc(N)c3c2)c1.O=C([O-])c1cccc(C(F)(F)F)c1>>Nc1ncnc2ccc(-c3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)cc12,,CN(C)C=O,,,,val
US20070112037A1,COc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(OCCN)cc2)cc1.CS(=O)(=O)Cl>>COc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(OCCNS(C)(=O)=O)cc2)cc1,,CCN(CC)CC,ClCCl,Cl,,val
US20080167307A1,CCCCCCCN(CCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1)c1ncc(C(=O)OC)cc1Cl>>CCCCCCCN(CCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1)c1ncc(C(=O)O)cc1Cl,,CCO,,[Na+].[OH-],,val
US20110152290A1,COC(=O)C1(NC(=O)c2ccc(Br)c(OCCc3cccc(C)c3)c2)Cc2ccccc2C1>>Cc1cccc(CCOc2cc(C(=O)NC3(C(=O)O)Cc4ccccc4C3)ccc2Br)c1,,C1COCCO1,,[Li+].[OH-],,val
US20110144105A1,CN(C)c1cccc(B(O)O)c1.Cc1ccc(S(=O)(=O)OC(=CC(C)C)c2cc3cccnc3n2S(=O)(=O)c2ccccc2)cc1>>CC(C)C=C(c1cccc(N(C)C)c1)c1cc2cccnc2n1S(=O)(=O)c1ccccc1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,C1COCCO1,CCOC(C)=O,O=C([O-])[O-].[Na+].[Na+],,val
US05610293,[Cl-].[Cl-].[Mn+2].c1ccc(CC2CNCCNCCNCCNCCN2)cc1>>ClN1CCNCCNCCNCCNCC1(Cl)Cc1ccccc1.[Mn+2],,CO,,,,val
US04092311,COC(=O)NN.Cc1cc(Cl)nnc1-c1ccc(C#N)cc1>>COC(=O)NNc1cc(C)c(-c2ccc(C#N)cc2)nn1,,CCCCO,,,,val
US20160039834A1,COC(=O)N1CCC(Nc2nc(-c3cc(O)ccc3C(F)(F)F)nc(-c3c(C)noc3C)c2C)CC1.O=[N+]([O-])c1cccc(S(=O)(=O)OC[C@H]2CO2)c1>>COC(=O)N1CCC(Nc2nc(-c3cc(OC[C@H]4CO4)ccc3C(F)(F)F)nc(-c3c(C)noc3C)c2C)CC1,,C1CCOC1,O,O=C([O-])[O-].[Cs+].[Cs+],,val
US05434188,COc1ccc2ccc(C(=O)O)c(OC(C)C)c2c1.NCc1ccccc1>>COc1ccc2ccc(C(=O)NCc3ccccc3)c(OC(C)C)c2c1,,C1CCOC1,CCOC(C)=O,O=C(n1ccnc1)n1ccnc1,,val
US20100168418A1,COc1ccc2ncc(=O)n(CCN3CCC(N)CC3)c2c1.O=Cc1cc2c(cn1)OCCO2>>COc1ccc2ncc(=O)n(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2c1,,CC(=O)O,ClC(Cl)Cl,O=C([O-])O.[Na+],,val
US05670505,O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2ccc([N+](=O)[O-])cc2)C[C@H]1Cc1c[nH]c2ccccc12>>Nc1ccc(CN2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](Cc3c[nH]c4ccccc34)C2)cc1,[Fe],CCO,,O,[Cl-].[NH4+],val
US20130320269A1,CCCCCCCCCC(=O)Nc1ccccc1Br.CCCC[Sn](CCCC)(CCCC)c1ccc([Sn](CCCC)(CCCC)CCCC)cc1.CN(C)C=O.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCCCCCCCCC(=O)Nc1ccccc1-c1ccc(-c2ccccc2NC(=O)CCCCCCCCC)cc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,CN(C)C=O,,,,val
US20030004181A1,CCOC(=O)CCN(C(=O)c1ccc2sc(CN(C)c3ccc(C(=N)N)cc3)nc2c1)c1ccccc1.Cl>>CN(Cc1nc2cc(C(=O)N(CCC(=O)O)c3ccccc3)ccc2s1)c1ccc(C(=N)N)cc1.Cl,,CO,,[Na+].[OH-],,val
US20060229349A1,CC(C)N1C(=O)Cc2cc(N3CC(CN)OC3=O)cc(F)c21.COC(=O)Cl>>COC(=O)NC[C@H]1CN(c2cc(F)c3c(c2)CC(=O)N3C(C)C)C(=O)O1,,ClCCl,,CCN(C(C)C)C(C)C,,val
US20150329552A1,CCOC(=O)c1cc2n(c1)CCCC(C#N)C2=O.NN>>CCOC(=O)c1cc2n(c1)CCCc1c(N)n[nH]c1-2,,CCO,,CC(=O)O,O,val
US20090163488A1,Cc1cccnc1C(=O)O.Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c1>>Cc1cccnc1C(=O)Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c1,CN(C)C=O,C1CCOC1,O,O=C(Cl)C(=O)Cl,,val
US20110059941A1,COC(=O)c1cc(OC(C)C)cc(O[C@@H](C)Cc2ccccc2)c1>>CC(C)Oc1cc(O[C@@H](C)Cc2ccccc2)cc(C(=O)O)c1,,CO,,Cl,[Na+].[OH-],val
US05994378,CCCC(Br)C(=O)OC(c1ccccc1)c1ccccc1.O=Cc1ccccc1O>>CCCC(Oc1ccccc1C=O)C(=O)OC(c1ccccc1)c1ccccc1,,CS(C)=O,O,Cl,O=C([O-])[O-].[K+].[K+],val
US03975502,C#N.O=C1CCCCC1>>N#CC1(O)CCCCC1,,O,,O=C([O-])[O-].[Na+].[Na+],,val
US20050026964A1,CNC.Cn1cc(C(=O)Oc2c(F)c(F)c(F)c(F)c2F)c(Nc2ccc(I)cc2F)cc1=O>>CN(C)C(=O)c1cn(C)c(=O)cc1Nc1ccc(I)cc1F,,C1CCOC1,,,,val
US06297239B1,O=C1CCC(=O)N1Br.OCc1ccc(I)c(Oc2ccc3ccccc3c2)c1>>BrCc1ccc(I)c(Oc2ccc3ccccc3c2)c1,,ClCCl,,CSC,,val
US07662581B1,CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)O.Nc1ccccc1NCc1ccccc1>>CC(C)C(NC(=O)OC(C)(C)C)C(=O)Nc1ccccc1NCc1ccccc1,,CCOC(C)=O,CN(C)C=O,CCN(CC)CC,CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F,val
US20010047115A1,FC(F)(Cl)C(F)(Cl)OC(F)(Cl)C(F)(F)C(F)(Cl)C(F)(F)Cl>>FC(F)=C(F)OC(F)(Cl)C(F)(F)C(F)=C(F)F,[Zn],CN(C)C=O,,,,val
US06214858B1,CN1C(=O)C(Cl)(Cl)c2cc(S(=O)(=O)Cl)ccc21.NCc1ccccc1>>CN1C(=O)C(Cl)(Cl)c2cc(S(=O)(=O)NCc3ccccc3)ccc21,,ClCCl,,Cl,,val
US20150018328A1,C[C@@H](N)C1CC1.FC(F)(F)c1cccc(-c2nc(Cl)cc(Cl)n2)n1>>C[C@@H](Nc1cc(Cl)nc(-c2cccc(C(F)(F)F)n2)n1)C1CC1,,C1CCOC1,,CCN(CC)CC,,val
US20100120706A1,Nc1nc(N)c2ncn(CCCl)c2n1.O=Cc1cccnc1>>Nc1nc(NCc2cccnc2)nc2c1ncn2CCCl,,CO,,CC(=O)O,[BH3-]C#N.[Na+],val
US20150266895A1,CC(=O)Nc1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12>>CC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12,,ClCCl,,CC[SiH](CC)CC,O=C(O)C(F)(F)F,val
US20140323480A1,CC(=O)O.O=[N+]([O-])c1ccc(N2CCOCC2)nc1NCc1cccc(Cl)c1Cl>>Cc1nc2ccc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1Cl,[Fe],,,,,val
US20120071461A1,COC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccc3ccccc13)CC2>>O=C(O)c1ccc2c(c1)[C@H](NC(=O)c1cccc3ccccc13)CC2,,CO,O,[Li]O,,val
US20130035331A1,Cc1ccnc(Nc2cccc(-c3cnc(-c4ccc(C#N)cc4)s3)n2)c1.OO>>Cc1ccnc(Nc2cccc(-c3cnc(-c4ccc(C(N)=O)cc4)s3)n2)c1,,CCO,,N,,val
US07659279B2,CCOc1cc(OC[C@H]2CCCN2)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1.O=C(O)CO>>CCOc1cc(OC[C@H]2CCCN2C(=O)CO)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1,,CS(C)=O,ClCCl,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20030027748A1,CCOC(=O)CCCCCOCCOCCOCCOCCOCCOCCOCCOC>>COCCOCCOCCOCCOCCOCCOCCOCCCCCC(=O)O,,[Na+],[OH-],,,val
US05206240,CCOC(=O)C1(Cc2ccccc2)CCN(C(=O)c2ccccc2)CC1>>O=C(c1ccccc1)N1CCC(Cc2ccccc2)(C(=O)O)CC1,,CS(C)=O,,Cl,CC(C)(C)[O-].[K+],val
US20080125437A1,CC(C)(C)OCCCO.O=C1c2ccccc2C(=O)N1O>>CC(C)(C)OCCCON1C(=O)c2ccccc2C1=O,,C1CCOC1,,CC(C)OC(=O)N=NC(=O)OC(C)C,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110092501A1,CCOC(OCC)OCC.C[Si](C)(C)C#N.Nc1ccc2nc[nH]c2c1.O=Cc1ccccc1>>O=C1NCN(c2ccc3[nH]cnc3c2)C1c1ccccc1,,Cl,,[BH4-].[Na+],,val
US20070191420A1,CC(C)(C)C1CCC(C(=O)O)CC1.Nc1ccncc1>>CC(C)(C)C1CCC(C(=O)Nc2ccncc2)CC1,CN(C)C=O,ClCCl,,O=C(Cl)C(=O)Cl,c1ccncc1,val
US20120214762A1,C#C[Mg]Br.CC(=O)c1ncn(C)n1>>C#CC(C)(O)c1ncn(C)n1,,C1CCOC1,,,,val
US04276417,C=CCN(CC=C)c1nc(NC(=O)OCC(C)C)[n+]([O-])c(NC(=O)OCC(C)C)n1>>C=CCN(CC=C)c1nc(NC(=O)OCC(C)C)n2oc(=O)nc2n1,,O,,ClCCl,[Na+].[OH-],val
US05059611,COC(=O)CCc1coc([Si](C)(C)C)c1>>C[Si](C)(C)c1cc(CCC(=O)O)co1,,CCO,O,[K+].[OH-],,val
US20150284408A1,Cc1ccc(CNC2CCN(C(=O)OC(C)(C)C)CC2)cn1>>Cc1ccc(CNC2CCNCC2)cn1,,C1COCCO1,ClCCl,Cl,,val
US20060004017A1,COc1cc2c(Cl)ncnc2cc1OCCCN1CCCCC1.Oc1ccc2cccnc2c1>>COc1cc2c(Oc3ccc4cccnc4c3)ncnc2cc1OCCCN1CCCCC1,,CN(C)C=O,,[Na+].[OH-],O=C([O-])[O-].[K+].[K+],val
US20070259851A1,CC(C)(C)OC(=O)N1CCC(=O)CC1.COC(CN)OC>>COC(CNC1CCN(C(=O)OC(C)(C)C)CC1)OC,,ClCCCl,,CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+],,val
US06518282B1,O=S(=O)(Cl)c1ccc(Br)cc1.OCCOc1ccc2ccccc2c1>>O=S(=O)(OCCOc1ccc2ccccc2c1)c1ccc(Br)cc1,,ClCCl,O,CCN(CC)CC,Cl,val
US04438036,CC(=O)N/C=C/SC1=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)N2C(=O)[C@H]([C@@H](C)OC=O)[C@H]2C1>>CC(=O)N/C=C/SC1=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)N2C(=O)[C@H]([C@@H](C)O)[C@H]2C1,,C1COCCO1,,CCOC(C)=O,[Na+].[OH-],val
US20140206663A1,CC(C)(C)OC(=O)N1CC(=O)C1.CC1C(=O)NN=C2COc3cc(C4CC4)c(N)cc3N21>>CC1C(=O)NN=C2COc3cc(C4CC4)c(NC4CN(C(=O)OC(C)(C)C)C4)cc3N21,,CC(=O)O,CCO,[BH3-]C#N.[Na+],,val
US20120059014A1,CC(C)c1noc(N2CCC([C@H](C)CCO)CC2)n1.Oc1ncc(Br)cn1>>CC(C)c1noc(N2CCC([C@H](C)CCOc3ncc(Br)cn3)CC2)n1,,C1CCOC1,,CCOC(=O)N=NC(=O)OCC,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20110281870A1,[N-]=[N+]=N[C@H]1CC[C@@H]2CN(Cc3ccccc3)C[C@H]12>>N[C@H]1CC[C@@H]2CN(Cc3ccccc3)C[C@H]12,[Ni],CCO,,[H][H],,val
US20140221333A1,CC(C)(C)OC(=O)N1CCCC(=O)C1.Clc1nccn2cncc12>>CC(C)(C)OC(=O)N1CCCC(O)(c2ncc3c(Cl)nccn23)C1,,C1CCOC1,,[Li]CCCC,,val
US20040214798A1,CC(=O)Oc1cc([N+](=O)[O-])ccc1CBr.O>>O=[N+]([O-])c1ccc(CO)c(O)c1,,C1COCCO1,O,O=C([O-])[O-].[Ca+2],,val
US20070105904A1,ClCc1ccc(Oc2ccccc2)nc1.Nc1ccc(-c2cn[nH]c2)c(N)n1>>Nc1ccc(-c2cnn(Cc3ccc(Oc4ccccc4)nc3)c2)c(N)n1,,CN(C)C=O,,[H-].[Na+],,val
US20080021032A1,CC(=O)OC(C)=O.CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(CCO)n2)cc1Cl>>CC(=O)OCCn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)n1,,CCOC(C)=O,c1ccncc1,,,val
US20030176454A1,COC(=O)C1CCc2ccsc2C1=O.N=CN>>Oc1ncnc2c1CCc1ccsc1-2,,O,,CC(=O)O,,val
US05610144,CC(C)(C)OC(=O)[C@H]1CS[C@@H](c2ccccc2)N1C(=O)CN.Cc1cccc(N=C=O)c1>>Cc1cccc(NC(=O)NCC(=O)N2[C@H](c3ccccc3)SC[C@@H]2C(=O)OC(C)(C)C)c1,,C1CCCCC1,,ClC(Cl)Cl,,val
US20140288094A1,C=CC(=O)OCC.N#Cc1c(-c2cccnc2)n[nH]c1N>>CCOC(=O)CCn1nc(-c2cccnc2)c(C#N)c1N,,c1ccncc1,,O,,val
US20120316161A1,CCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc(C)cc1Cl>>CCCC(C(=O)O)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc(C)cc1Cl,,CO,,[Na+].[OH-],,val
US20150126490A1,CN1CC(c2ccc(N)nc2)CC1=O.O=C1CCC(=O)N1Br>>CN1CC(c2cnc(N)c(Br)c2)CC1=O,,CC#N,CCOC(C)=O,O=C([O-])O.[Na+],,val
US20160207928A1,N#Cc1ccccc1Nc1nc2cnc(-c3cccc(C(=O)O)c3)cn2n1.NC1CCCC1>>N#Cc1ccccc1Nc1nc2cnc(-c3cccc(C(=O)NC4CCCC4)c3)cn2n1,,C1CCOC1,O,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20070043040A1,COc1ccc(CC(N)Cc2ccc(OC)cc2)cc1.Clc1ccc(OCCCBr)c(Cc2ccccc2)c1>>COc1ccc(C(NCCCOc2ccc(Cl)cc2Cc2ccccc2)c2ccc(OC)cc2)cc1,,C1COCCO1,CCOC(C)=O,CCN(C(C)C)C(C)C,O=C([O-])O.[Na+],val
US20130079313A1,COc1ccc(C(=O)OCc2ccccc2)cc1N(CC(N)=O)S(C)(=O)=O>>COc1ccc(C(=O)O)cc1N(CC(N)=O)S(C)(=O)=O,[Pd],CO,ClC(Cl)Cl,,,val
US20060247238A1,O=C(Br)CBr.O=C(N[C@@H]1CCNC1)c1ccc(Cl)s1>>O=C(N[C@@H]1CCN(C(=O)CBr)C1)c1ccc(Cl)s1,,C1CCOC1,,Cl,,val
US20060160868A1,COC(=O)C(Cc1ccc(OCc2ccccc2)cc1)Sc1ncc(-c2ccccc2)[nH]1>>O=C(O)C(Cc1ccc(OCc2ccccc2)cc1)Sc1ncc(-c2ccccc2)[nH]1,,CO,O,Cl,[K+].[OH-],val
US20140200216A1,C[C@H]1CN(c2ccncc2NC(=O)c2nc3cc(N4CCN(C)CC4)ccc3cc2NC(=O)OCc2ccccc2)C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C>>C[C@H]1CN(c2ccncc2NC(=O)c2nc3cc(N4CCN(C)CC4)ccc3cc2N)C[C@@H](N)[C@@H]1O,[Pd],CO,,[H][H],,val
US20100137317A1,COc1ccc(C2=CC(=O)C(C)(C)O2)cc1C#N.O=C1CCC(=O)N1Br>>COc1ccc(C2=C(Br)C(=O)C(C)(C)O2)cc1C#N,,ClC(Cl)Cl,ClCCl,,,val
US05273975,CCCN(CCC)C1Cc2cccc(C(=O)OC)c2NC1=O>>CCCN(CCC)C1Cc2cccc(C(=O)O)c2NC1=O,,CO,,[Na+].[OH-],,val
US20020103229A1,O=C(Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1)C(=O)c1c[nH]c2ccccc12>>O=C(Nc1cccc(-c2n[nH]c3ccc(-c4nc[nH]n4)cc23)c1)C(=O)c1c[nH]c2ccccc12,,C1COCCO1,Cl,,,val
US20040077605A1,N#Cc1ccc(N)cc1C(F)(F)F.O=C1C=CC(=O)O1>>N#Cc1ccc(N2C(=O)C=CC2=O)cc1C(F)(F)F,,CC(=O)O,,,,val
US06143764,COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.COc1cccc(N=C=O)c1>>COc1cccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)c1,,Cc1ccccc1,,CCCCCC,CCOC(C)=O,val
US20160038602A1,CC(=O)O.CCOC(=O)CC(=O)C(C)(C)C.NNCCOCCOCCC(=O)O>>CC1=NN(CCOCCOCCC(=O)O)C(=O)C1,,CC(=O)O,,,,val
US20080039514A1,CCOCC.CC[C@@]1(C(=O)OC)Cc2ccccc2O1.CO.C[Si](C)(C)C#N.O>>COc1cccc2c3c(ccc12)OCC(C)(C#N)O3,,O,,FB(F)F,,val
US20040072860A1,CCOC(=O)CC1C(=O)NCCN1S(=O)Oc1cc2ccc(Cl)cc2s1.Cc1ccc(C#N)cc1Br>>CCOC(=O)CC1C(=O)N(Cc2ccc(C#N)cc2)CCN1S(=O)Oc1cc2ccc(Cl)cc2s1,,CCOC(C)=O,CN(C)C=O,O=C([O-])[O-].[Cs+].[Cs+],,val
US20120115841A1,[N-]=[N+]=NCc1cc(F)c(Br)cc1F>>NCc1cc(F)c(Br)cc1F,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20140336198A1,CC(C)[Mg]Cl.O=Cc1ccc(OC(F)F)cc1>>CC(C)C(O)c1ccc(OC(F)F)cc1,,C1CCOC1,,,,val
US20060106027A1,COc1cc(N)cc(OC)c1OC.CS(=O)(=O)c1nccc(-c2c[nH]nc2-c2ccc(Cl)cc2Cl)n1>>COc1cc(Nc2nccc(-c3c[nH]nc3-c3ccc(Cl)cc3Cl)n2)cc(OC)c1OC,,CC(=O)O,,,,val
US20050026987A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1cc2cc(NC(C)=O)ccc2[nH]1>>CCOC(=O)c1cc2cc(NC(C)=O)ccc2n1C(=O)OC(C)(C)C,CN(C)c1ccncc1,ClCCl,,,,val
US20140142307A1,Br.BrCc1ccc2ccccc2c1.Clc1nc[nH]c1Cl.O=C(O)CCCCCBr>>O=C(O)CCCCCn1c[n+](Cc2ccc3ccccc3c2)c(Cl)c1Cl.[Br-],,CC#N,,[K+].[OH-],,val
US20100094000A1,C=CCn1nc(C)cc1-c1ccc(F)cc1.CC(C)=O.C[N+]1([O-])CCOCC1>>Cc1cc(-c2ccc(F)cc2)n(CC(O)O)n1,,O,,,,val
US20160229814A1,CCN1C(=O)C2(CCC2)Oc2cc([N+](=O)[O-])ccc21>>CCN1C(=O)C2(CCC2)Oc2cc(N)ccc21,[Pd],CO,,[H][H],,val
US20040259912A1,COC(=O)c1cc(N)ccc1OC(c1ccc(F)cc1)c1ccccc1F.COc1ccc(N=C=O)cc1OC>>COC(=O)c1cc(NC(=O)Nc2ccc(OC)c(OC)c2)ccc1OC(c1ccc(F)cc1)c1ccccc1F,,C1CCOC1,,,,val
US20040132727A1,CC(C)C(O)c1ccccc1.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3cc(C)c(NC(=O)OC(c4ccccc4)C(C)C)cc3C)c2cc1OC,,ClCCl,,CCN(CC)CC,Cc1ccccc1,val
US06204279B1,CC(C)(C)c1ccc2oc(C(O)[C@@H](CCc3ccccc3)NC(=O)OCc3ccccc3)nc2c1>>CC(C)(C)c1ccc2oc(C(O)[C@H](N)CCc3ccccc3)nc2c1,[Pd],CO,,,,val
US05003106,CCCCc1ccc(C(=O)Cl)cc1.NCCCCCCO>>CCCCc1ccc(C(=O)NCCCCCCO)cc1,,ClCCl,,CCN(CC)CC,,val
US20110046113A1,C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)NCCCCN.Cn1ccnc1CN(Cc1ccc(C(=O)O)cc1)Cc1nccn1C>>CCCN(CCC)CCCCNC(=O)c1ccc(CN(Cc2nccn2C)Cc2nccn2C)cc1,,CN(C)C=O,,On1nnc2ccccc21,,val
US04323688,CCCCc1ccc(N)c(N)c1.CCOCC(=O)O>>CCCCc1ccc2nc(COCC)[nH]c2c1,,CCOC(C)=O,,,,val
US04885298,CC=C1C(=S)c2cc(C)ccc2OC1c1ccccc1.O=C(OO)c1cccc(Cl)c1>>CC=C1C(=S)c2cc(C)ccc2[O+]([O-])C1c1ccccc1,,ClCCl,,,,val
US06323206B1,NCCCO.O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)C1c2ccccc2CSc2ccccc21)Oc1ccccc1>>O=C(NCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)C1c2ccccc2CSc2ccccc21,,CCOC(C)=O,CN(C)C=O,O,O=C([O-])[O-].[K+].[K+],val
US04889857,CCOC(=O)c1cn(C2CC2)c2c(F)c(N3CCOC(CN(C)C(=O)OCC)C3)c(F)cc2c1=O>>CNCC1CN(c2c(F)cc3c(=O)ccn(C4CC4)c3c2F)CCO1,,Cl,,,,val
US20080188531A1,Cc1nc(N)sc1C(=O)CBr.N#CCC(N)=S>>Cc1nc(N)sc1-c1csc(CC#N)n1,,CCO,,Br,,val
US06492355B1,CC(C)(C)OC(=O)N1CCNCC1.O=C(NCC12CC3CC(CC(C3)C1)C2)c1cccc(Cl)c1[N+](=O)[O-]>>O=C(NCC12CC3CC(CC(C3)C1)C2)c1cccc(N2CCNCC2)c1[N+](=O)[O-],,CS(C)=O,O,,,val
US20060252741A1,CNc1ncc(F)cc1C#N.NO>>CNc1ncc(F)cc1C(=N)NO,,CCO,,CCN(CC)CC,Cl,val
US04263037,CC(C)(CO)c1cc(C#N)ccc1O.O=S(Cl)Cl>>CC1(C)COS(=O)Oc2ccc(C#N)cc21,,CCOCC,,O,c1ccncc1,val
US06881736B1,N#CCc1nc(C(F)(F)F)cs1.O=Cc1ccc(OCc2ccccc2)cc1>>N#CC(=Cc1ccc(OCc2ccccc2)cc1)c1nc(C(F)(F)F)cs1,,CCO,,[H-].[Na+],,val
US20090029965A1,CCOC(=O)c1cnn(C)c1Nc1ccc(C)cc1[N+](=O)[O-]>>CCOC(=O)c1cnn(C)c1Nc1ccc(C)cc1N,,CO,,Cl[Sn]Cl,,val
US20140005213A1,CCN(CC)S(F)(F)F.[N-]=[N+]=N[C@@H]1CN([C@H](c2ccc(Cl)nc2)C(F)(F)F)C[C@@H]1O>>[N-]=[N+]=N[C@@H]1CN([C@H](c2ccc(Cl)nc2)C(F)(F)F)CC1F,,ClCCl,,,,val
US20080070924A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN1CCNCC1.O=C1CCN(Cc2ccccc2)CC1>>CN1CCN(C2CCN(C(=O)OC(C)(C)C)CC2)CC1,[Pd],C1CCOC1,CO,,,val
US20140296225A1,CC(O)c1ccc(N)cc1.O=C1CCC(=O)N1Br>>Nc1ccc(CCO)cc1Br,,CCOC(C)=O,,CN(C)C=O,,val
US20110263626A1,N.O=Cc1ccc(Oc2ccccc2Cl)cc1F>>NCc1ccc(Oc2ccccc2Cl)cc1F,[Ni],,,[H][H],,val
US20080058423A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)C(=O)c1ccc2c(CN)cccc2c1>>CN(C)C(=O)c1ccc2c(CNC(=O)OC(C)(C)C)cccc2c1,,ClCCl,,,,val
US05608109,O=C(NN=C(CNC(=O)c1ccccc1)c1cccc(Cl)c1)Nc1ccc(OC(F)(F)F)cc1>>O=C(NNC(CNC(=O)c1ccccc1)c1ccc(Cl)cc1)Nc1ccc(OC(F)(F)F)cc1,,CO,,Cl,[BH3-]C#N.[Na+],val
US20060142265A1,CN(Cc1sc2c(F)cccc2c1Cl)C(=O)/C=C/c1ccc(N)nc1.Cl>>CN(Cc1sc2c(F)cccc2c1Cl)C(=O)/C=C/c1ccc(N)nc1.Cl,,CCOCC,ClCCl,,,val
US20130210811A1,CC(C)(C)OC(=O)c1ccnc(Cl)n1.C[C@@H]1CN(c2ccc(S(C)(=O)=O)cc2)CCN1>>C[C@@H]1CN(c2ccc(S(C)(=O)=O)cc2)CCN1c1nccc(C(=O)OC(C)(C)C)n1,,CC#N,,CCN(C(C)C)C(C)C,,val
US20120220635A1,CC(C)(C)OC(=O)NCCc1ccc(N)cc1.CC(C)c1ccc(S(=O)(=O)Cl)cc1>>CC(C)c1ccc(S(=O)(=O)Nc2ccc(CCNC(=O)OC(C)(C)C)cc2)cc1,,c1ccncc1,,,,val
US20110039824A1,CC(C)OC(=O)C1=CN(C(=O)c2ccc(OCCBr)cc2)CC(C)(C)c2c1[nH]c1ccccc21.CN1CCNCC1>>CC(C)OC(=O)C1=CN(C(=O)c2ccc(OCCN3CCN(C)CC3)cc2)CC(C)(C)c2c1[nH]c1ccccc21,,CN1CCCC1=O,,CCN(CC)CC,CO,val
US20100273754A1,Cn1c(N[C@@H]2CCC[C@H]2O)nc2n[nH]c(Nc3ccccc3)c2c1=O>>CN1C(=O)c2c(n[nH]c2Nc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12,,ClCCl,,O=S(Cl)Cl,,val
US20060022584A1,CC1=CC(=C(C#N)C#N)C=C(C(C)(C)C)O1.O=Cc1ccc(-c2ccc(N(c3ccccc3)c3ccccc3)cc2)s1>>CC(C)(C)C1=CC(=C(C#N)C#N)C=C(C=Cc2ccc(-c3ccc(N(c4ccccc4)c4ccccc4)cc3)s2)O1,,CCO,,C1CCNCC1,,val
US20090042967A1,C[C@@H]1N(C(=O)OC(C)(C)C)C(=O)C[C@]1(C)O>>C[C@@H]1NC(=O)C[C@]1(C)O,,CCOC(C)=O,Cl,,,val
US20130059853A1,COCOc1c(-c2ccc3c(c2)COC3=O)ccc(OC)c1OCC1CC1>>COc1ccc(-c2ccc3c(c2)COC3=O)c(O)c1OCC1CC1,,CO,,Cl,,val
US20110147681A1,CCN(CCO)c1ccc(C2=CC(=O)C(=O)c3ccccc32)cc1.NO>>CCN(CCO)c1ccc(C2=CC(=NO)C(=O)c3ccccc32)cc1,,CCO,,Cl,,val
US20040167030A1,CN1CCN(c2ccc([N+](=O)[O-])cn2)CC1.O=S(=O)(CCl)c1ccccc1>>CN1CCN(c2ccc([N+](=O)[O-])c(CS(=O)(=O)c3ccccc3)n2)CC1,,C1CCOC1,,CC(C)(C)[O-].[K+],,val
US20020132796A1,CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCC3=O)cc1F>>CC1(C)CCC(=O)c2ccc(C#Cc3ccc(C(=O)O)c(F)c3)cc21,,CCO,CO,[Na+].[OH-],,val
US05021420,CC(O)Cc1cc2cccc3c2c(c1Br)NS3(=O)=O.OC(CBr)CBr>>OC(CBr)CN1Sc2cccc3cccc1c23,,CN(C)C=O,,[H-].[Na+],,val
US20120022080A1,COC(=O)c1cc(Cl)ccc1NC(=O)CCl.Oc1ccccc1Br>>COC(=O)c1cc(Cl)ccc1NC(=O)COc1cccc(Br)c1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20050027119A1,COC(=O)C(C)=O.Nc1ccc(F)c(F)c1F>>COC(=O)C(C)Nc1ccc(F)c(F)c1F,[Pd],CO,,Cl,,val
US20140121200A1,CC(C)(C)OC(=O)N1CC(CN=[N+]=[N-])CC(O[Si](C)(C)C(C)(C)C)C1>>CC(C)(C)OC(=O)N1CC(CN)CC(O[Si](C)(C)C(C)(C)C)C1,[Pd],CCOC(C)=O,,,,val
US05656573,FC(F)(F)Oc1ccc(Br)c(Cl)c1.O=C=O>>O=C(O)c1ccc(OC(F)(F)F)cc1Cl,,CCOCC,,[Li]CCCC,,val
US06143764,COc1cc2nccc(Cl)c2cc1OC.O=C(C(=O)c1ccco1)c1ccc(O)cc1>>COc1cc2nccc(Oc3ccc(C(=O)C(=O)c4ccco4)cc3)c2cc1OC,CN(C)c1ccncc1,Cc1ccccc1C,,,,val
US20130274260A1,O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(CCl)cc1.c1c[nH]cn1>>O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(Cn2ccnc2)cc1,,C1CCOC1,,[I-].[Na+],,val
US20060154955A1,CCOC(=O)C(Cc1nc(-c2ccccc2)ccc1NC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1>>O=C(NC1Cc2nc(-c3ccccc3)ccc2NC1=O)OCc1ccccc1,,ClCCl,O=C(O)C(F)(F)F,,,val
US20030236426A1,CCOC(=N)c1ccc(OCc2ccccc2)cc1OCc1ccccc1>>CCOC(=N)c1ccc(O)cc1O,[Pd],CCO,,[H][H],,val
US20090186879A1,CI.OC(c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl)C(F)(F)F>>COC(c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl)C(F)(F)F,,C1CCOC1,CCOC(C)=O,[H-].[Na+],,val
US20120165309A1,Nc1ccc(F)cc1N.O=C(O)C(F)F>>Fc1ccc2[nH]c(C(F)F)nc2c1,,CCOC(C)=O,,O,[Na+].[OH-],val
US20070004704A1,CCOc1ccc(CC(=O)Nc2ccc(S(=O)(=O)Nc3ccccc3C(=O)OC)cc2)cc1>>CCOc1ccc(CC(=O)Nc2ccc(S(=O)(=O)Nc3ccccc3C(=O)O)cc2)cc1,,C1CCOC1,,Cl,[Li+].[OH-],val
US20110110889A1,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cc(C(O)c4ccc(Cl)cc4)c3c2)c1F>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cc(C(=O)c4ccc(Cl)cc4)c3c2)c1F,O=[Mn]=O,ClC(Cl)Cl,,,,val
US20130281452A1,CCI.Cc1cc(N2CCOCC2)cc(O)c1C(=O)NCc1ccc(Cl)cc1>>CCOc1cc(N2CCOCC2)cc(C)c1C(=O)NCc1ccc(Cl)cc1,,CC(C)=O,,O=C([O-])[O-].[K+].[K+],,val
US20150112073A1,O=C(O)CCSCCC(F)(F)F.O=S(Cl)Cl>>O=C(Cl)CCSCCC(F)(F)F,,ClCCl,,,,val
US05451594,Clc1nc2cc3c(cc2s1)OCO3.NC(N)=S>>Sc1nc2cc3c(cc2s1)OCO3,,CCO,,,,val
US20130085138A1,CN.S=C=Nc1ccc(Cl)c(Cl)c1>>CNC(=S)Nc1ccc(Cl)c(Cl)c1,,CCO,,,,val
US20100216788A1,COC(=O)c1cccc(Oc2ccc(Nc3ncnc4ccn(C)c34)cc2Cl)c1>>Cn1ccc2ncnc(Nc3ccc(Oc4cccc(C(=O)O)c4)c(Cl)c3)c21,,C1CCOC1,,CO,[Na+].[OH-],val
US20100120741A1,Nc1cc(Cl)ccc1[N+](=O)[O-].O=N[O-]>>NNc1cc(Cl)ccc1[N+](=O)[O-],,Cl,O,Cl[Sn]Cl,,val
US04532343,CI.CN(C)C=O.Cc1ccc(C(=O)O)cc1O>>COC(=O)c1ccc(C)c(OC)c1,,O,,O=C([O-])[O-].[K+].[K+],,val
US20080275046A1,COC(=O)C(Cl)C(C)=O.NC(=S)c1ccc(OCCCCl)cc1>>COC(=O)c1sc(-c2ccc(OCCCCl)cc2)nc1C,,CO,ClCCl,,,val
US05969133,CCCCCCCCOc1cc(C(=O)OC)ccc1N(CCCl)CCCl>>CCCCCCCCOc1cc(C(=O)O)ccc1N(CCCl)CCCl,,Cl,,,,val
US20010003782A1,COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2C3=CC=C4C(C)(C)[C@@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C>>COC(=O)CC[C@@H](C)[C@H]1CC=C2C3=C(CC[C@@]21C)[C@@]1(C)CC[C@H](O)C(C)(C)[C@@H]1CC3,,CO,Cl,,,val
US08471005B2,CSc1ncc2ccc(Br)n2n1.c1cn[nH]c1>>CSc1ncc2ccc(-n3cccn3)n2n1,[Cu]I,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20030060470A1,CC(C)(C)OC(=O)NCc1ccccc1B(O)O.CCOC(=O)c1ncccc1Br>>CCOC(=O)c1ncccc1-c1ccccc1CNC(=O)OC(C)(C)C,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,ClCCl,,COCCOC,O=C([O-])[O-].[Na+].[Na+],val
US20160145252A1,CC(C)Nc1cc(-c2cccc(Cl)n2)ncc1-c1nnc(C(=O)N2CC[C@@H](O)C2)s1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>CC(C)Nc1cc(-c2cccc(-c3cnn(C)c3)n2)ncc1-c1nnc(C(=O)N2CC[C@@H](O)C2)s1,Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1,O,,CN(C)C=O,O=C([O-])O.[Na+],val
US20110166142A1,CCC1Oc2cc(OC(C)=O)ccc2CC1c1ccc(OC(C)=O)cc1>>CCC1Oc2cc(O)ccc2CC1c1ccc(O)cc1,,CO,O,CC(=O)O,[K+].[OH-],val
US05306824,CCCOc1oc(=O)c2cc(N)ccc2c1Cl.O=C(CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21)Nc1ccc2c(Cl)c(OCCc3ccccc3)oc(=O)c2c1>>CCCOc1oc(=O)c2cc(NC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@@H]43)ccc2c1Cl,,O,,,,val
US04369312,CC1=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(=NO)[C@H]2SC1>>CC1=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)[C@@H](NO)[C@H]2SC1,,CCO,CCOC(C)=O,Cl,,val
US20100004331A1,COC(=O)Cc1ccc(O)c(Oc2ccc([N+](=O)[O-])cc2CSCC(F)(F)F)c1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)Cc1ccc(OS(=O)(=O)C(F)(F)F)c(Oc2ccc([N+](=O)[O-])cc2CSCC(F)(F)F)c1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US07105517B2,BrBr.CSc1nccc(CC(=O)c2ccccc2)n1>>CSc1nccc(C(Br)C(=O)c2ccccc2)n1,,CC(=O)O,,,,val
US04312883,C=CCc1c(O)cc(C)c2ccc(=O)oc12>>Cc1cc2occc2c2oc(=O)ccc12,,CCOC(C)=O,,O=O,,val
US20030232818A1,CCOC(=O)c1cn(Cc2ccc(OC)cc2OC)c2nc(N3CCCC3)c(F)cc2c1=O>>COc1ccc(Cn2cc(C(=O)O)c(=O)c3cc(F)c(N4CCCC4)nc32)c(OC)c1,,C1CCOC1,CO,[Li+].[OH-],,val
US20130296344A1,COc1cc(C2(O)C(C(=N)NC(=O)CCl)=C(N)Oc3c2ccc2ccccc32)cc(Br)c1OC>>COc1cc(C2C(c3noc(CCl)n3)=C(N)Oc3c2ccc2ccccc32)cc(Br)c1OC,,Cc1ccccc1C,O,,,val
US20130102776A1,CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2OCC3=O)CC1.O=Cc1n[nH]c2ncccc12>>CC(C)(C)OC(=O)N1CCN(Cc2c(O)ccc3c2O/C(=C\c2n[nH]c4ncccc24)C3=O)CC1,C1CCNCC1,CO,,,,val
US20130059834A1,CN(C)CCCCl.FC(F)Oc1ccc2[nH]nc(I)c2c1>>CN(C)CCCn1nc(I)c2cc(OC(F)F)ccc21,,CN(C)C=O,,O,O=C([O-])[O-].[K+].[K+],val
US20160159796A1,CCOC(=O)C(F)(F)F.O=C(O)NCCNC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O>>O=C(NCCNC(=O)C(F)(F)F)c1ncc2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O,,C1CCOC1,ClCCl,CCN(CC)CC,O=C(O)C(F)(F)F,val
US20140275158A1,COc1cc2c(cc1OC(C)C)C(c1ccc(Cl)cc1)N(C1CCC(C(C)=O)CC1)C(=O)C2.C[Mg]Br>>COc1cc2c(cc1OC(C)C)C(c1ccc(Cl)cc1)N(C1CCC(C(C)(C)O)CC1)C(=O)C2,,C1CCOC1,,,,val
US20140275172A1,CC(C)(C)C(=O)Cl.Nc1c(S)cc(Cl)cc1Br>>CC(C)(C)c1nc2c(Br)cc(Cl)cc2s1,,CN1CCCC1=O,,,,val
US20090264466A1,CC(C)(C)OC(=O)NCC(=O)N1CCC(CO)(C(=O)NCc2ncc[nH]2)CC1.CCc1ccc(N=C=O)cc1>>CCc1ccc(NC(=O)OCC2(C(=O)NCc3ncc[nH]3)CCN(C(=O)CNC(=O)OC(C)(C)C)CC2)cc1,CN(C)c1ccncc1,C1CCOC1,,,,val
US04388317,CN(C)Cc1ccc(CSCCN)s1.CN(C)Cc1ccc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)s1>>CN(C)Cc1ccc(CSCCNc2ncc(Cc3ccc(CN(C)C)s3)c(=O)[nH]2)s1,,c1ccncc1,,,,val
US20100216814A1,Cc1ccc2c(c1)c1c(n2CC(O)(c2ccncc2)C(C)C)CCN(C)C1>>CC(C)=C(Cn1c2c(c3cc(C)ccc31)CN(C)CC2)c1ccncc1,,ClCCl,,CN(C)C=O,O=S(Cl)Cl,val
US20090042227A1,CC[N+](CC)(CC)CCCBr.Cc1ccnc2ccccc12.[Br-]>>CC[N+](CC)(CC)CCC[n+]1ccc(C)c2ccccc21.[Br-].[Br-],,CC#N,,,,val
US20110294780A1,O=Cc1ccc2c(c1)c(Br)nn2Cc1ccc(Cl)cc1C(F)(F)F.OB(O)c1ccc(F)cc1>>O=Cc1ccc2c(c1)c(-c1ccc(F)cc1)nn2Cc1ccc(Cl)cc1C(F)(F)F,,COCCOC,O,O=C([O-])[O-].[Na+].[Na+],,val
US20100130495A1,Cc1nccn1-c1ccc(Nc2nc3c(c(OS(=O)(=O)C(F)(F)F)n2)CN(C(=O)OC(C)(C)C)CC3)cc1.OC[C@@H]1Cc2ccccc2N1>>Cc1nccn1-c1ccc(Nc2nc3c(c(N4c5ccccc5C[C@H]4CO)n2)CN(C(=O)OC(C)(C)C)CC3)cc1,,CN(C)C=O,,,,val
US20040171634A1,Brc1ccc2ccccc2c1.COc1cc(-c2ccc3c(I)nn(S(=O)(=O)c4c(C)cc(C)cc4C)c3c2)ccc1OCc1ccccc1>>COc1cc(-c2ccc3c(-c4ccc5ccccc5c4)nn(S(=O)(=O)c4c(C)cc(C)cc4C)c3c2)ccc1OCc1ccccc1,c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1,C1CCOC1,,[Li]CCCC,O=C([O-])O.[Na+],val
US06184250B2,C1=COCCC1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O=C([O-])O.O=C1CC2C(CC(O)C2CC[C@@H](O)COc2cccc(C(F)(F)F)c2)O1>>O=C1C[C@@H]2[C@@H](CC[C@H](COc3cccc(C(F)(F)F)c3)OC3CCCCO3)[C@H](OC3CCCCO3)C[C@@H]2O1,,ClCCl,,O,,val
US05075476,CCC(C)(C)O.CSc1ccc(OC(=O)Cl)cc1>>CCC(C)(C)OC(=O)Oc1ccc(SC)cc1,,ClCCl,,c1ccncc1,,val
US20070072853A1,C=CCC(C)(C)C(=O)O.Nc1cc(NS(=O)(=O)c2ccccc2)ccc1NCC1CCCCC1>>C=CCC(C)(C)c1nc2cc(NS(=O)(=O)c3ccccc3)ccc2n1CC1CCCCC1,,CN(C)C=O,,CCN(C(C)C)C(C)C,CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F,val
US20020193599A1,CCOC(=O)CCCBr.[N-]=[N+]=[N-]>>CCOC(=O)CCCN=[N+]=[N-],,CO,,O,,val
US20090093524A1,CC(C)c1nnn(-c2c(Cl)cccc2Cl)c1CCl.COC(=O)c1ccc(-c2ccc(O)cc2C)cc1>>COC(=O)c1ccc(-c2ccc(OCc3c(C(C)C)nnn3-c3c(Cl)cccc3Cl)cc2C)cc1,,CN(C)C=O,,O=C([O-])[O-].[Cs+].[Cs+],,val
US20090170874A1,C#C[Si](C)(C)C.COCC(C)NC(=O)c1cc(N=[N+]=[N-])cc(-c2ccc(C)cc2)c1>>COCC(C)NC(=O)c1cc(-c2ccc(C)cc2)cc(-n2ccnn2)c1,,CN(C)C=O,,,,val
US20070027173A1,Cc1noc(C)c1COS(C)(=O)=O.O=C1OC2(CCN(C(=O)c3c[nH]c4cc(Cl)ccc34)CC2)c2ccc(F)cc21>>Cc1noc(C)c1Cn1cc(C(=O)N2CCC3(CC2)OC(=O)c2cc(F)ccc23)c2ccc(Cl)cc21,,CO,,,,val
US20100280083A1,CC(C)I.COc1cc(-c2noc(C)n2)c(C(=O)O)cc1OCc1ccccc1>>COc1cc(-c2noc(C)n2)c(C(=O)OC(C)C)cc1OCc1ccccc1,,CCOC(C)=O,O,CN(C)C=O,O=C([O-])[O-].[K+].[K+],val
US20070197531A1,O=C(c1ccc(F)cc1)C1(O)CCN(Cc2ccccc2)CC1>>O=C(c1ccc(F)cc1)C1(O)CCNCC1,[Pd],CCOC(C)=O,,CO,,val
US04205072,O=C(Cc1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(CO)CS[C@H]12.O=C=NC(=O)C(Cl)(Cl)Cl>>NC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)Cc3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)[C@H]2SC1,,ClCCl,,O=C([O-])O.[Na+],,val
US20040236084A1,CC(C)(C)OC(=O)N1CCN(c2ccc(N)nc2)CC1.CS(=O)c1ncc(C#N)c(NC2CCCC2)n1>>CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3ncc(C#N)c(NC4CCCC4)n3)nc2)CC1,,Cc1ccccc1,,,,val
US20060094743A1,CC(C)CCON=O.Cc1ccc2c(c1)C(=O)CC2>>Cc1ccc2c(c1)C(=O)C(=NO)C2,,CCO,,C1COCCO1,Cl,val
US20110136763A1,CCOC(=O)CC1OB(O)c2cc(Oc3ccc(C#N)cn3)cc(C)c21>>Cc1cc(Oc2ccc(C#N)cn2)cc2c1C(CC(=O)O)OB2O,,C1CCOC1,CO,[Na+].[OH-],,val
US04738970,C=CCOc1c(C)cnc2c1CCCC2Sc1nc2ccccc2[nH]1.O=C(OO)c1cccc(Cl)c1>>C=CCOc1c(C)cnc2c1CCCC2S(=O)c1nc2ccccc2[nH]1,,ClCCl,,,,val
US20040058965A1,Cc1oc(-c2ccccc2)nc1COc1cc(CO)on1.O=S(Cl)Cl>>Cc1oc(-c2ccccc2)nc1COc1cc(CCl)on1,,Cc1ccccc1,,O=C([O-])O.[Na+],,val
US05852010,[N-]=[N+]=NC1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O>>NC1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O,,C1CCOC1,,O,c1ccc(P(c2ccccc2)c2ccccc2)cc1,val
US20100324010A1,CC(=O)OC(C)=O.CC(C)CN(C(=O)c1cnc(C(C)(C)C)nc1NCc1ccco1)[C@H]1C[C@@H](N)CN(C(=O)OC(C)(C)C)C1>>CC(=O)N[C@@H]1C[C@H](N(CC(C)C)C(=O)c2cnc(C(C)(C)C)nc2NCc2ccco2)CN(C(=O)OC(C)(C)C)C1,,ClCCCl,,CCN(CC)CC,Cl,val
US20110319378A1,CC[C@@H](C=CC#N)N1C(=O)[C@@](C)(CC2COC(C)(C)O2)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1>>CC[C@@H](CCC#N)N1C(=O)[C@@](C)(CC2COC(C)(C)O2)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1,[Pd],CCO,,[H][H],,val
US20140142083A1,CCN(c1cccc(C(=O)OC)c1C)C1CCC(C)(O)CC1.CI>>CCN(c1cccc(C(=O)OC)c1C)C1CCC(C)(OC)CC1,,C1CCOC1,,[H-].[Na+],,val
US20030055055A1,CCOC(=O)N1CCNCC1.O=[N+]([O-])c1cccc(CBr)c1>>CCOC(=O)N1CCN(Cc2cccc([N+](=O)[O-])c2)CC1,,CN1CCCC1=O,,CCN(CC)CC,CCOCC,val
US20070117818A1,CN(C)CCCN.COc1cc(-c2ccc3[nH]c(NC(=O)c4cccs4)nc3c2)nc(S(C)(=O)=O)n1>>CN(C)CCCNc1nc(-c2ccc3[nH]c(NC(=O)c4cccs4)nc3c2)cc(=O)[nH]1,,O,,,,val
US20100273744A1,O=C(O)c1ccc(I)cc1C(F)(F)F>>OCc1ccc(I)cc1C(F)(F)F,,C1CCOC1,,CO,,val
US20070219186A1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCc1ccc(C(=O)OC)cc1C(F)(F)F>>COC(=O)c1ccc(CN(C)C(=O)OC(C)(C)C)c(C(F)(F)F)c1,,ClCCl,,CCN(CC)CC,,val
US20040053913A1,CC(C)OC=C(Br)C=O.N=C(N)Cc1ccccc1>>O=Cc1c[nH]c(Cc2ccccc2)n1,,ClC(Cl)Cl,,CCN(CC)CC,,val
US20100216814A1,CC(C)[Si](C#Cn1c2c(c3cc(Cl)ccc31)CN(C)CC2)(C(C)C)C(C)C>>C#Cn1c2c(c3cc(Cl)ccc31)CN(C)CC2,,C1CCOC1,O,CCCC[N+](CCCC)(CCCC)CCCC.[F-],,val